Cancer_type QTL_type tag_SNP LD SNP SNP_position Alleles Methylation_probe Methylation_position Probe_related_gene Beta t-stat Correlation_coefficient (r) p-value Traits LUSC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg26958806 chr6:27640298 NA 0.67 5.75 0.3 1.96e-8 Depression; LUSC cis rs12476592 0.602 rs2121351 chr2:63828361 G/A cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs1863824 0.625 rs7091192 chr10:88167456 A/G cg07322936 chr10:88137208 NA -0.67 -9.63 -0.47 1.52e-19 Schizophrenia; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.89 0.75 1.43e-62 Prudent dietary pattern; LUSC cis rs11690935 0.655 rs12052995 chr2:172537212 A/G cg13550731 chr2:172543902 DYNC1I2 0.59 9.34 0.46 1.39e-18 Schizophrenia; LUSC cis rs2835872 0.965 rs857946 chr21:39009303 A/T cg20424643 chr21:39039972 KCNJ6 0.38 5.88 0.31 1.02e-8 Electroencephalographic traits in alcoholism; LUSC cis rs804280 0.509 rs13276433 chr8:11783036 A/G cg21775007 chr8:11205619 TDH 0.47 6.74 0.35 7e-11 Myopia (pathological); LUSC cis rs17854409 1.000 rs66634465 chr20:61482306 C/T cg05147244 chr20:61493195 TCFL5 0.89 6.68 0.34 9.98e-11 Obesity-related traits; LUSC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg02269571 chr22:50332266 NA 0.58 8.83 0.43 6.13e-17 Schizophrenia; LUSC cis rs10489525 0.560 rs10858062 chr1:115602563 A/G cg01522456 chr1:115632236 TSPAN2 0.51 7.52 0.38 5.19e-13 Autism; LUSC cis rs3761218 0.668 rs6052079 chr20:3774209 G/T cg02737268 chr20:3780182 CDC25B 0.36 6.9 0.35 2.58e-11 Bipolar disorder; LUSC trans rs62103177 0.810 rs62096746 chr18:77619556 T/A cg14227996 chr4:17616232 MED28 0.8 8.14 0.41 7.99e-15 Opioid sensitivity; LUSC trans rs2204008 0.749 rs4579984 chr12:38166266 A/G cg06521331 chr12:34319734 NA -0.41 -6.38 -0.33 5.96e-10 Bladder cancer; LUSC trans rs6982636 0.967 rs2954031 chr8:126491733 G/T cg13325919 chr3:181432053 SOX2;SOX2OT -0.32 -6.25 -0.32 1.28e-9 Lipid metabolism phenotypes; LUSC cis rs9875589 0.509 rs1844107 chr3:14065319 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.12 0.36 6.54e-12 Ovarian reserve; LUSC cis rs6556937 0.627 rs4590196 chr5:95997285 G/T cg01741836 chr5:95996644 CAST 0.43 6.02 0.31 4.61e-9 Blood protein levels; LUSC cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg04455712 chr21:45112962 RRP1B 0.46 8.65 0.43 2.23e-16 Mean corpuscular volume; LUSC cis rs478607 0.831 rs59739006 chr11:64415903 C/T cg19131476 chr11:64387923 NRXN2 0.34 6.06 0.31 3.76e-9 Urate levels; LUSC cis rs6740322 0.948 rs6715072 chr2:43562230 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.43 -5.93 -0.31 7.56e-9 Coronary artery disease; LUSC cis rs8072100 0.967 rs8074149 chr17:45583375 A/C cg08085267 chr17:45401833 C17orf57 0.52 8.39 0.42 1.39e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs9929218 1.000 rs67359183 chr16:68814204 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -12.09 -0.55 3.58e-28 Colorectal cancer; LUSC trans rs6480314 0.542 rs12572954 chr10:70030523 G/T cg04882175 chr6:131122610 NA -0.54 -6.15 -0.32 2.17e-9 Optic nerve measurement (disc area); LUSC cis rs12541635 0.966 rs12544362 chr8:106976344 A/C cg10147462 chr8:107024639 NA 0.56 9.8 0.47 4.11e-20 Age of smoking initiation; LUSC cis rs887829 0.570 rs10168155 chr2:234596836 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.28 -0.33 1.04e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs4356932 0.967 rs4478212 chr4:76958899 A/G cg00809888 chr4:76862425 NAAA 0.34 5.75 0.3 1.98e-8 Blood protein levels; LUSC cis rs11122272 0.668 rs1122131 chr1:231476501 A/G cg06096015 chr1:231504339 EGLN1 0.53 9.06 0.44 1.11e-17 Hemoglobin concentration; LUSC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs2637266 1.000 rs2894337 chr10:78344871 C/T cg18941641 chr10:78392320 NA 0.38 7.07 0.36 8.85e-12 Pulmonary function; LUSC cis rs1863824 0.625 rs11202023 chr10:88165453 C/T cg07322936 chr10:88137208 NA -0.67 -9.82 -0.47 3.54e-20 Schizophrenia; LUSC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg08975724 chr8:8085496 FLJ10661 -0.45 -6.5 -0.34 2.86e-10 Joint mobility (Beighton score); LUSC cis rs66887589 0.934 rs56843000 chr4:120516597 T/C cg09307838 chr4:120376055 NA -0.47 -7.23 -0.37 3.42e-12 Diastolic blood pressure; LUSC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg08219700 chr8:58056026 NA 0.46 6.03 0.31 4.26e-9 Developmental language disorder (linguistic errors); LUSC cis rs11148252 0.595 rs9526974 chr13:53251040 C/G cg00495681 chr13:53174319 NA 0.8 15.51 0.65 2.93e-41 Lewy body disease; LUSC cis rs2652834 0.851 rs4633662 chr15:63424286 G/A cg05507819 chr15:63340323 TPM1 0.45 5.78 0.3 1.72e-8 HDL cholesterol; LUSC cis rs11585357 0.793 rs112597506 chr1:17628832 A/G cg08277548 chr1:17600880 PADI3 -0.6 -6.26 -0.32 1.17e-9 Hair shape; LUSC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg24829409 chr8:58192753 C8orf71 -0.59 -6.54 -0.34 2.36e-10 Developmental language disorder (linguistic errors); LUSC cis rs920590 0.643 rs2083641 chr8:19660217 A/C cg03894339 chr8:19674705 INTS10 0.41 5.85 0.31 1.15e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12519773 0.597 rs4342312 chr5:92477890 C/A cg18783429 chr5:92414398 NA 0.34 7.34 0.37 1.63e-12 Migraine; LUSC cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -11.29 -0.53 2.85e-25 Systemic lupus erythematosus; LUSC cis rs859767 0.540 rs17789633 chr2:135386474 G/T cg12500956 chr2:135428796 TMEM163 0.27 6.51 0.34 2.72e-10 Neuroticism; LUSC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg07701084 chr6:150067640 NUP43 0.56 8.6 0.43 3.23e-16 Lung cancer; LUSC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3859192 0.599 rs2270401 chr17:38176256 A/T cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.54 0.57 8.07e-30 White blood cell count; LUSC cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg16586182 chr3:47516702 SCAP 0.49 7.26 0.37 2.76e-12 Colorectal cancer; LUSC cis rs4561483 0.831 rs33648 chr16:11979622 G/A cg08843971 chr16:11963173 GSPT1 -0.45 -6.41 -0.33 4.83e-10 Testicular germ cell tumor; LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.81e-10 Bipolar disorder; LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg02475777 chr4:1388615 CRIPAK 0.44 6.5 0.34 2.92e-10 Obesity-related traits; LUSC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg11062466 chr8:58055876 NA 0.7 8.6 0.43 3.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs13006833 0.668 rs291466 chr2:191184475 A/G cg21644426 chr2:191273491 MFSD6 0.43 6.14 0.32 2.41e-9 Urinary metabolites; LUSC cis rs9325144 0.671 rs35817541 chr12:38975001 T/C cg26384229 chr12:38710491 ALG10B -0.65 -10.05 -0.48 6e-21 Morning vs. evening chronotype; LUSC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg12963246 chr6:28129442 ZNF389 -0.52 -7.34 -0.37 1.68e-12 Depression; LUSC cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg06784218 chr1:46089804 CCDC17 0.5 9.72 0.47 7.96e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3771570 1.000 rs56363214 chr2:242227157 A/G cg21155796 chr2:242212141 HDLBP 0.68 7.51 0.38 5.46e-13 Prostate cancer; LUSC cis rs7267979 0.714 rs2474763 chr20:25241295 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.25 0.56 9.31e-29 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg14784868 chr12:69753453 YEATS4 0.7 11.44 0.53 8.42e-26 Blood protein levels; LUSC cis rs10751667 0.961 rs6597954 chr11:987677 G/A cg06064525 chr11:970664 AP2A2 -0.36 -7.07 -0.36 8.88e-12 Alzheimer's disease (late onset); LUSC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg06637938 chr14:75390232 RPS6KL1 0.5 7.85 0.39 5.57e-14 Height; LUSC trans rs1997103 1.000 rs6953494 chr7:55412157 G/A cg20935933 chr6:143382018 AIG1 0.51 7.43 0.38 8.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg08045932 chr20:61659980 NA 0.56 9.62 0.47 1.67e-19 Prostate cancer (SNP x SNP interaction); LUSC cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg18964960 chr10:1102726 WDR37 0.47 6.55 0.34 2.17e-10 Response to angiotensin II receptor blocker therapy; LUSC trans rs11098499 0.954 rs878373 chr4:120237484 A/T cg25214090 chr10:38739885 LOC399744 0.54 7.91 0.4 3.85e-14 Corneal astigmatism; LUSC cis rs977987 0.872 rs1542864 chr16:75471378 G/A cg03315344 chr16:75512273 CHST6 0.53 10.32 0.49 7.71e-22 Dupuytren's disease; LUSC cis rs9807989 0.801 rs11123925 chr2:102977511 G/A cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs12220238 1.000 rs7904207 chr10:75884474 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 7.69 0.39 1.65e-13 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs977987 0.800 rs11645329 chr16:75336679 C/G cg03315344 chr16:75512273 CHST6 0.48 8.9 0.44 3.61e-17 Dupuytren's disease; LUSC cis rs7264396 0.836 rs1886695 chr20:34180535 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.52 7.56 0.38 3.84e-13 Total cholesterol levels; LUSC cis rs9399135 0.967 rs4896123 chr6:135295410 T/G cg24558204 chr6:135376177 HBS1L 0.57 8.55 0.42 4.48e-16 Red blood cell count; LUSC cis rs9811920 0.809 rs766778 chr3:99751480 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 5.97 0.31 6.08e-9 Axial length; LUSC cis rs2832077 0.943 rs11701777 chr21:30155828 T/C cg24692254 chr21:30365293 RNF160 -0.54 -6.7 -0.34 8.77e-11 Cognitive test performance; LUSC cis rs16910800 0.906 rs2449436 chr11:23204720 G/T cg20040320 chr11:23191996 NA 0.44 6.52 0.34 2.58e-10 Cancer; LUSC cis rs17270561 0.608 rs4711102 chr6:25742075 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs354225 0.544 rs3796019 chr2:54807279 G/A cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs3768617 0.811 rs12738377 chr1:183031256 C/T ch.1.3577855R chr1:183094577 LAMC1 0.6 8.61 0.43 3.01e-16 Fuchs's corneal dystrophy; LUSC cis rs738322 0.804 rs4821743 chr22:38514906 A/G cg17652424 chr22:38574118 PLA2G6 -0.29 -5.9 -0.31 8.98e-9 Cutaneous nevi; LUSC cis rs7712401 0.715 rs395981 chr5:122347911 C/T cg19077854 chr5:122220652 SNX24 -0.41 -8.85 -0.44 5.29e-17 Mean platelet volume; LUSC cis rs7568458 0.905 rs10198569 chr2:85794415 C/T cg23752985 chr2:85803571 VAMP8 -0.31 -6.48 -0.33 3.31e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11112613 0.653 rs59504344 chr12:105950837 C/T cg03607813 chr12:105948248 NA 0.79 11.91 0.55 1.72e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -5.89 -0.31 9.39e-9 Developmental language disorder (linguistic errors); LUSC cis rs12540874 0.698 rs12718574 chr7:50573848 G/C cg18232548 chr7:50535776 DDC -0.59 -8.59 -0.43 3.39e-16 Systemic sclerosis; LUSC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg00825309 chr19:58991885 ZNF446 -0.52 -7.62 -0.38 2.64e-13 Uric acid clearance; LUSC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg06558623 chr16:89946397 TCF25 1.11 9.73 0.47 7.07e-20 Skin colour saturation; LUSC trans rs804280 0.509 rs13276433 chr8:11783036 A/G cg06636001 chr8:8085503 FLJ10661 0.51 7.62 0.38 2.59e-13 Myopia (pathological); LUSC cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.59 0.65 1.52e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs11214589 0.747 rs10502172 chr11:113199146 C/T cg14159747 chr11:113255604 NA 0.26 6.42 0.33 4.68e-10 Neuroticism; LUSC cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.51 7.58 0.38 3.41e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs870825 0.616 rs2141257 chr4:185609463 C/T cg04058563 chr4:185651563 MLF1IP -0.82 -12.37 -0.56 3.44e-29 Blood protein levels; LUSC trans rs1005277 0.579 rs1780116 chr10:38526621 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.23 -0.45 3.29e-18 Extrinsic epigenetic age acceleration; LUSC cis rs4834770 1.000 rs1397613 chr4:120242929 G/T cg24375607 chr4:120327624 NA 0.41 5.84 0.3 1.26e-8 Blood protein levels; LUSC cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg15744005 chr10:104629667 AS3MT -0.34 -7.17 -0.37 4.94e-12 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs11167764 0.945 rs891991 chr5:141484977 A/T cg08523384 chr5:141488047 NDFIP1 -0.51 -7.21 -0.37 3.71e-12 Crohn's disease; LUSC cis rs3126085 0.935 rs11583524 chr1:152161657 T/C cg26876637 chr1:152193138 HRNR -0.45 -5.96 -0.31 6.29e-9 Atopic dermatitis; LUSC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg26408565 chr15:76604113 ETFA 0.53 8.77 0.43 9.05e-17 Blood metabolite levels; LUSC cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg15839431 chr19:19639596 YJEFN3 0.61 6.6 0.34 1.63e-10 Bipolar disorder; LUSC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg12564285 chr5:131593104 PDLIM4 -0.35 -6.51 -0.34 2.75e-10 Blood metabolite levels; LUSC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.13 0.58 4.86e-32 Hip circumference adjusted for BMI; LUSC cis rs9300255 0.602 rs1716167 chr12:123651162 C/T cg13010344 chr12:123464640 ARL6IP4 0.44 5.97 0.31 6.06e-9 Neutrophil percentage of white cells; LUSC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg09034736 chr1:150693464 HORMAD1 0.4 5.73 0.3 2.2e-8 Melanoma; LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg27284194 chr4:1044797 NA 0.37 6.05 0.31 3.88e-9 Obesity-related traits; LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg07507251 chr3:52567010 NT5DC2 -0.32 -6.16 -0.32 2.07e-9 Bipolar disorder; LUSC trans rs2204008 0.548 rs8189475 chr12:38037115 C/T cg06521331 chr12:34319734 NA -0.4 -6.36 -0.33 6.48e-10 Bladder cancer; LUSC cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg05347473 chr6:146136440 FBXO30 0.52 8.54 0.42 4.68e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs17270561 0.779 rs12210620 chr6:25884785 T/C cg17042849 chr6:26104293 HIST1H4C -0.48 -5.89 -0.31 9.6e-9 Iron status biomarkers; LUSC cis rs1355223 0.506 rs1509659 chr11:34865133 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.8 -0.35 4.79e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9910055 1.000 rs9910055 chr17:42283037 C/T cg08499158 chr17:42289980 UBTF -0.56 -8.96 -0.44 2.37e-17 Total body bone mineral density; LUSC cis rs859767 0.501 rs6705916 chr2:135397569 C/T cg12500956 chr2:135428796 TMEM163 -0.27 -6.49 -0.33 3.07e-10 Neuroticism; LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg23758822 chr17:41437982 NA 1.04 20.17 0.74 1.03e-59 Menopause (age at onset); LUSC cis rs6598955 0.502 rs6683157 chr1:26545865 G/A cg04990556 chr1:26633338 UBXN11 0.85 11.21 0.52 5.72e-25 Obesity-related traits; LUSC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg24209194 chr3:40518798 ZNF619 0.42 5.69 0.3 2.76e-8 Renal cell carcinoma; LUSC cis rs868036 0.958 rs4261478 chr15:68074084 G/A cg08079166 chr15:68083412 MAP2K5 0.41 8.47 0.42 8.02e-16 Restless legs syndrome; LUSC cis rs3862435 0.572 rs2589969 chr15:90908051 T/C cg22089800 chr15:90895588 ZNF774 0.58 6.3 0.33 9.47e-10 Response to exercise (triglyceride level interaction); LUSC cis rs4443100 1.000 rs4443100 chr22:23372864 C/G cg14186256 chr22:23484241 RTDR1 0.47 5.9 0.31 8.73e-9 Serum parathyroid hormone levels; LUSC cis rs7615952 0.688 rs7624806 chr3:125599074 G/A cg05084668 chr3:125655381 ALG1L -0.74 -10.88 -0.51 8.21e-24 Blood pressure (smoking interaction); LUSC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg16228356 chr17:43848958 NA -0.27 -6.28 -0.33 1.03e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9300255 0.722 rs12298826 chr12:123829028 A/G cg00376283 chr12:123451042 ABCB9 -0.65 -7.67 -0.39 1.91e-13 Neutrophil percentage of white cells; LUSC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg02269571 chr22:50332266 NA -0.55 -8.2 -0.41 5.16e-15 Schizophrenia; LUSC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg01842473 chr11:617407 IRF7;MUPCDH -0.63 -8.59 -0.43 3.4e-16 Systemic lupus erythematosus; LUSC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg27432699 chr2:27873401 GPN1 -0.58 -8.68 -0.43 1.72e-16 Total body bone mineral density; LUSC cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg01028140 chr2:1542097 TPO -0.61 -8.28 -0.41 2.9e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs1728785 0.688 rs7203363 chr16:68587692 T/A cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.4e-10 Ulcerative colitis; LUSC trans rs629535 0.679 rs62511660 chr8:70157089 G/A cg21567404 chr3:27674614 NA -0.93 -13.48 -0.59 2.32e-33 Dupuytren's disease; LUSC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs7923609 0.871 rs7898861 chr10:65319678 T/C cg01631684 chr10:65280961 REEP3 0.41 6.05 0.31 3.79e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs11098499 0.954 rs28685688 chr4:120420334 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg05412045 chr2:3337680 TSSC1 -0.36 -5.98 -0.31 5.82e-9 N-glycan levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00293631 chr22:28315337 LOC284900;PITPNB -0.4 -6.2 -0.32 1.71e-9 Electrocardiographic conduction measures; LUSC cis rs68170813 0.652 rs6976759 chr7:107158506 A/G cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg23583168 chr7:148888333 NA -0.92 -17.96 -0.7 6.13e-51 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg25019033 chr10:957182 NA -0.53 -6.0 -0.31 5.01e-9 Eosinophil percentage of granulocytes; LUSC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC trans rs11098499 0.954 rs1546505 chr4:120241224 A/G cg25214090 chr10:38739885 LOC399744 0.57 8.17 0.41 6.24e-15 Corneal astigmatism; LUSC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg09796270 chr17:17721594 SREBF1 -0.45 -8.24 -0.41 3.89e-15 Total body bone mineral density; LUSC trans rs11098499 0.909 rs10002083 chr4:120311152 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs9329289 0.510 rs10903785 chr10:2550063 C/T cg15501526 chr10:2543763 NA 0.56 9.89 0.48 2.09e-20 Age-related hearing impairment; LUSC cis rs10191773 0.589 rs11676628 chr2:112953355 A/G cg07905836 chr2:113190072 RGPD8;RGPD5 -0.68 -7.65 -0.39 2.11e-13 Yeast infection; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg20891283 chr12:69753455 YEATS4 0.65 10.16 0.49 2.71e-21 Blood protein levels; LUSC cis rs10927875 0.864 rs12135073 chr1:16167799 C/T cg22431228 chr1:16359049 CLCNKA -0.39 -7.1 -0.36 7.66e-12 Dilated cardiomyopathy; LUSC cis rs17193922 0.876 rs17194040 chr16:53550898 C/T cg09728985 chr16:53543985 NA -0.4 -6.81 -0.35 4.53e-11 Hip circumference adjusted for BMI; LUSC cis rs208520 0.954 rs72884027 chr6:66995044 T/G cg07460842 chr6:66804631 NA 0.93 12.09 0.55 3.65e-28 Exhaled nitric oxide output; LUSC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.51 7.94 0.4 3.2e-14 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg05425664 chr17:57184151 TRIM37 -0.57 -8.34 -0.42 1.96e-15 Intelligence (multi-trait analysis); LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg07424592 chr7:64974309 NA -0.41 -5.81 -0.3 1.45e-8 Calcium levels; LUSC cis rs6977940 0.730 rs73033432 chr7:2891037 C/T cg19731401 chr7:2775893 GNA12 0.69 7.54 0.38 4.62e-13 White matter integrity; LUSC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg20243544 chr17:37824526 PNMT 0.5 7.11 0.36 6.96e-12 Asthma; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg05025164 chr4:1340916 KIAA1530 -0.64 -10.53 -0.5 1.43e-22 Longevity; LUSC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg20503657 chr10:835505 NA 0.82 11.66 0.54 1.36e-26 Eosinophil percentage of granulocytes; LUSC cis rs4363385 0.597 rs6679201 chr1:152976840 C/A cg25856811 chr1:152973957 SPRR3 -0.34 -5.7 -0.3 2.69e-8 Inflammatory skin disease; LUSC cis rs5770917 1.000 rs2269385 chr22:51010939 G/A cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.59 -5.7 -0.3 2.66e-8 Narcolepsy; LUSC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.66 10.5 0.5 1.71e-22 Cognitive test performance; LUSC cis rs271674 1.000 rs271674 chr17:47978986 A/G cg05310240 chr17:47979069 NA -0.38 -7.5 -0.38 5.88e-13 White matter hyperintensity volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy; LUSC cis rs597539 0.552 rs10792006 chr11:68722306 T/C cg21963583 chr11:68658836 MRPL21 -0.4 -6.57 -0.34 1.92e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg08280861 chr8:58055591 NA 0.52 5.73 0.3 2.21e-8 Developmental language disorder (linguistic errors); LUSC cis rs6084875 0.840 rs2065705 chr20:4719407 A/G cg26097573 chr20:4721490 PRNT 0.31 5.77 0.3 1.78e-8 Systemic lupus erythematosus; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg10729496 chr3:10149963 C3orf24 -0.49 -6.19 -0.32 1.77e-9 Alzheimer's disease; LUSC cis rs1577917 1.000 rs12207610 chr6:86688016 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.28 -0.41 2.9e-15 Response to antipsychotic treatment; LUSC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg24675658 chr1:53192096 ZYG11B -0.62 -10.17 -0.49 2.45e-21 Monocyte count; LUSC cis rs11605924 0.901 rs6485644 chr11:45855998 C/T ch.11.939596F chr11:45881766 CRY2 -0.5 -7.4 -0.38 1.13e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs926938 0.527 rs6680112 chr1:115548915 G/C cg01522456 chr1:115632236 TSPAN2 -0.41 -6.3 -0.33 9.18e-10 Autism; LUSC cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -6.98 -0.36 1.64e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg22903471 chr2:27725779 GCKR 0.37 6.31 0.33 8.83e-10 Total body bone mineral density; LUSC cis rs2692947 0.644 rs772175 chr2:96944553 G/A cg23100626 chr2:96804247 ASTL 0.29 6.83 0.35 4.11e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.8 -0.35 4.88e-11 Lung cancer; LUSC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11644478 chr21:40555479 PSMG1 0.94 18.56 0.71 2.36e-53 Cognitive function; LUSC cis rs1729951 0.575 rs835642 chr3:136703365 A/T cg12473912 chr3:136751656 NA 0.4 7.17 0.37 4.99e-12 Neuroticism; LUSC cis rs7177699 0.557 rs34372090 chr15:79110735 C/T cg00540400 chr15:79124168 NA -0.46 -7.98 -0.4 2.32e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs55728055 0.661 rs9619215 chr22:32042732 A/G cg01338084 chr22:32026380 PISD 0.77 5.88 0.31 9.77e-9 Age-related hearing impairment; LUSC cis rs75804782 0.521 rs55657931 chr2:239422072 A/G cg18131467 chr2:239335373 ASB1 -0.69 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs4363385 0.818 rs4284210 chr1:152985711 G/A cg00922841 chr1:152955080 SPRR1A -0.42 -7.09 -0.36 7.87e-12 Inflammatory skin disease; LUSC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.58 -5.66 -0.3 3.3e-8 Cerebrospinal P-tau181p levels; LUSC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.4 -5.99 -0.31 5.42e-9 Menarche (age at onset); LUSC trans rs7618501 0.602 rs2301166 chr3:50148305 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.58 -0.46 2.32e-19 Intelligence (multi-trait analysis); LUSC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg07424592 chr7:64974309 NA 0.7 6.2 0.32 1.67e-9 Diabetic kidney disease; LUSC cis rs240764 0.658 rs9399685 chr6:101204318 C/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.32e-9 Neuroticism; LUSC cis rs7524258 0.835 rs2412150 chr1:7303343 A/C cg07173049 chr1:7289937 CAMTA1 0.35 7.32 0.37 1.82e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg11663144 chr21:46675770 NA -0.43 -7.37 -0.37 1.35e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg16797656 chr11:68205561 LRP5 0.35 6.0 0.31 5.2e-9 Total body bone mineral density; LUSC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg13607699 chr17:42295918 UBTF 0.53 8.18 0.41 5.97e-15 Total body bone mineral density; LUSC cis rs35306767 0.668 rs12784928 chr10:1083617 A/C cg26597838 chr10:835615 NA 0.56 7.33 0.37 1.74e-12 Eosinophil percentage of granulocytes; LUSC cis rs9527 0.567 rs11191573 chr10:104896816 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg16647868 chr5:131706066 SLC22A5 0.39 6.03 0.31 4.23e-9 Acylcarnitine levels; LUSC cis rs7681440 0.647 rs6824979 chr4:90819407 C/G cg15133208 chr4:90757351 SNCA 0.35 5.89 0.31 9.44e-9 Dementia with Lewy bodies; LUSC cis rs11645898 0.935 rs72787094 chr16:72192613 C/A cg14768367 chr16:72042858 DHODH -0.64 -6.99 -0.36 1.47e-11 Blood protein levels; LUSC cis rs859767 0.501 rs10928507 chr2:135396631 C/T cg12500956 chr2:135428796 TMEM163 0.28 6.68 0.34 9.8e-11 Neuroticism; LUSC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg04632378 chr13:21900426 NA 0.32 5.89 0.31 9.6e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC trans rs9944715 0.834 rs9949494 chr18:43811300 T/C cg01718231 chr17:29326311 RNF135 -0.5 -7.01 -0.36 1.29e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs55665837 0.524 rs2882128 chr11:14414634 A/C cg19336497 chr11:14380999 RRAS2 -0.53 -11.22 -0.52 5.31e-25 Vitamin D levels; LUSC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg17948913 chr5:572064 NA 0.36 6.08 0.32 3.32e-9 Obesity-related traits; LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg05313129 chr8:58192883 C8orf71 -0.52 -5.9 -0.31 9.1e-9 Developmental language disorder (linguistic errors); LUSC cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg08975724 chr8:8085496 FLJ10661 0.47 7.09 0.36 7.88e-12 Mood instability; LUSC cis rs9467773 0.572 rs13213953 chr6:26594534 T/A cg05738196 chr6:26577821 NA 0.77 13.68 0.6 3.8e-34 Intelligence (multi-trait analysis); LUSC cis rs11608355 0.545 rs33997929 chr12:109912064 C/T cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs7615952 0.932 rs1976458 chr3:125647512 T/G cg05084668 chr3:125655381 ALG1L -0.79 -12.02 -0.55 6.76e-28 Blood pressure (smoking interaction); LUSC cis rs10904908 1.000 rs7903259 chr10:17259642 C/G cg01003015 chr10:17271136 VIM 0.43 6.37 0.33 6.27e-10 Total cholesterol levels;Cholesterol, total; LUSC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7903847 0.642 rs2275090 chr10:99148151 A/G cg20016023 chr10:99160130 RRP12 -0.32 -7.95 -0.4 2.92e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs73001065 0.818 rs10500212 chr19:19723215 C/T cg03709012 chr19:19516395 GATAD2A 0.89 7.12 0.36 6.51e-12 LDL cholesterol; LUSC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg02807482 chr3:125708958 NA -0.52 -6.5 -0.33 2.98e-10 Blood pressure (smoking interaction); LUSC cis rs6424115 0.931 rs2473377 chr1:24148260 T/C cg15997130 chr1:24165203 NA 0.57 9.2 0.45 3.86e-18 Immature fraction of reticulocytes; LUSC cis rs10992471 0.603 rs1980848 chr9:95248571 A/G cg14631576 chr9:95140430 CENPP 0.34 6.17 0.32 2e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg22029157 chr1:209979665 IRF6 0.75 11.17 0.52 7.96e-25 Cleft lip with or without cleft palate; LUSC cis rs34779708 0.931 rs4934697 chr10:35287192 C/T cg03585969 chr10:35415529 CREM 0.64 9.06 0.44 1.14e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs9784649 0.641 rs72755823 chr5:25075537 T/C cg08600765 chr20:34638493 LOC647979 -0.67 -7.64 -0.39 2.25e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg23649088 chr2:200775458 C2orf69 -0.54 -6.96 -0.36 1.85e-11 Schizophrenia; LUSC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg07424592 chr7:64974309 NA 0.65 5.77 0.3 1.85e-8 Diabetic kidney disease; LUSC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg07936489 chr17:37558343 FBXL20 0.69 9.58 0.46 2.38e-19 Glomerular filtration rate (creatinine); LUSC cis rs9283706 0.608 rs13171572 chr5:66334552 T/A cg11590213 chr5:66331682 MAST4 0.44 6.42 0.33 4.75e-10 Coronary artery disease; LUSC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg23630131 chr7:65973040 NA -0.21 -5.71 -0.3 2.52e-8 Aortic root size; LUSC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg07936489 chr17:37558343 FBXL20 -0.73 -10.03 -0.48 7.03e-21 Glomerular filtration rate (creatinine); LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.83 0.63 1.46e-38 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00432041 chr8:67341355 RRS1 0.44 6.74 0.35 6.93e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10100465 0.961 rs6469699 chr8:118644899 A/C cg09430518 chr8:118662568 NA -0.3 -5.71 -0.3 2.43e-8 Leprosy; LUSC trans rs12210905 0.844 rs7773336 chr6:26993555 A/G cg11837749 chr1:55047332 ACOT11 0.55 6.0 0.31 5.25e-9 Hip circumference adjusted for BMI; LUSC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg19774624 chr17:42201019 HDAC5 -0.81 -13.73 -0.6 2.59e-34 Total body bone mineral density; LUSC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg14019146 chr3:50243930 SLC38A3 0.37 8.52 0.42 5.56e-16 Body mass index; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg00761861 chr14:68141669 VTI1B 0.38 5.96 0.31 6.45e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg18350739 chr11:68623251 NA -0.36 -6.54 -0.34 2.32e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs16937 0.711 rs4951172 chr1:205137578 A/G cg00857998 chr1:205179979 DSTYK -0.46 -6.47 -0.33 3.48e-10 Schizophrenia; LUSC cis rs2694528 0.623 rs3857238 chr5:60066325 C/G cg11474532 chr5:59995715 DEPDC1B -0.6 -6.19 -0.32 1.72e-9 Parkinson's disease; LUSC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg04287289 chr16:89883240 FANCA 0.77 6.23 0.32 1.42e-9 Skin colour saturation; LUSC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg00343986 chr7:65444356 GUSB 0.43 6.55 0.34 2.22e-10 Aortic root size; LUSC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg21984481 chr17:79567631 NPLOC4 0.55 10.62 0.5 6.59e-23 Eye color traits; LUSC cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg16482183 chr6:26056742 HIST1H1C 0.52 8.05 0.4 1.49e-14 Height; LUSC cis rs1595825 0.732 rs74885211 chr2:198419911 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.27 -0.32 1.15e-9 Ulcerative colitis; LUSC trans rs1493916 0.837 rs8088362 chr18:31413016 A/G cg27147174 chr7:100797783 AP1S1 -0.56 -8.69 -0.43 1.63e-16 Life satisfaction; LUSC cis rs12776158 0.901 rs57805780 chr10:71216455 A/C cg12610070 chr10:71211762 TSPAN15 -0.46 -6.05 -0.31 3.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs16867321 0.639 rs13028421 chr2:181444035 G/T cg23363182 chr2:181467187 NA 0.57 9.2 0.45 4.03e-18 Obesity; LUSC cis rs4588572 0.686 rs2362823 chr5:77693623 A/G cg11547950 chr5:77652471 NA 0.51 7.54 0.38 4.47e-13 Triglycerides; LUSC cis rs9430161 0.611 rs34032547 chr1:11034374 C/G cg02454025 chr1:11042201 C1orf127 1.03 18.59 0.71 1.77e-53 Ewing sarcoma; LUSC cis rs11098499 0.954 rs11935596 chr4:120412457 G/C cg24375607 chr4:120327624 NA 0.79 12.05 0.55 5.19e-28 Corneal astigmatism; LUSC cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.32 0.53 2.37e-25 Colorectal cancer; LUSC cis rs6712932 1.000 rs6746579 chr2:105843223 G/T cg22878388 chr2:105853796 NA -0.33 -6.02 -0.31 4.68e-9 Type 2 diabetes; LUSC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.46 0.42 8.44e-16 Height; LUSC cis rs7927592 0.513 rs3853616 chr11:68198252 A/G cg20283391 chr11:68216788 NA -0.51 -7.33 -0.37 1.71e-12 Total body bone mineral density; LUSC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg16744531 chr19:17905626 B3GNT3 0.45 6.68 0.34 1.01e-10 Tumor biomarkers; LUSC cis rs2836633 1.000 rs2836634 chr21:40068230 T/A cg05519781 chr21:40033154 ERG 0.62 10.03 0.48 7.47e-21 Coronary artery disease; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg06600287 chr1:53387719 ECHDC2 -0.29 -6.31 -0.33 9.06e-10 Monocyte count; LUSC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg23985595 chr17:80112537 CCDC57 -0.3 -5.71 -0.3 2.55e-8 Life satisfaction; LUSC cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg02175503 chr12:58329896 NA 0.48 6.98 0.36 1.57e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg11764359 chr7:65958608 NA 0.58 8.62 0.43 2.82e-16 Aortic root size; LUSC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg11645453 chr3:52864694 ITIH4 -0.42 -10.37 -0.49 5.15e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs11800820 0.536 rs10802409 chr1:246632031 C/T cg16700716 chr1:246684329 NA 0.34 5.65 0.3 3.37e-8 Obesity-related traits; LUSC cis rs56146971 0.763 rs55950330 chr14:91872978 C/T cg10511902 chr14:91842949 CCDC88C 0.46 5.97 0.31 6.14e-9 Alzheimer disease and age of onset; LUSC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs7561273 0.586 rs7580772 chr2:24357657 T/C cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC cis rs3845702 0.736 rs6433818 chr2:180810264 A/T cg01881094 chr2:180872142 CWC22 -1.06 -12.8 -0.57 8.48e-31 Schizophrenia; LUSC cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg20476274 chr7:133979776 SLC35B4 0.8 13.19 0.59 2.96e-32 Mean platelet volume; LUSC cis rs7582180 0.663 rs2309800 chr2:100992086 C/T cg12002119 chr2:101014098 CHST10 0.35 5.83 0.3 1.3e-8 Intelligence (multi-trait analysis); LUSC cis rs11785400 1.000 rs9720653 chr8:143731939 T/G cg24634471 chr8:143751801 JRK 0.6 8.99 0.44 1.83e-17 Schizophrenia; LUSC cis rs1847202 0.859 rs7634316 chr3:72941452 C/G cg25664220 chr3:72788482 NA 0.38 6.27 0.32 1.13e-9 Motion sickness; LUSC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg13206674 chr6:150067644 NUP43 0.56 8.89 0.44 3.91e-17 Lung cancer; LUSC cis rs9837602 0.935 rs17392948 chr3:99754498 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 5.82 0.3 1.36e-8 Breast cancer; LUSC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg26769984 chr7:1090371 C7orf50 0.7 9.84 0.47 3.06e-20 Bronchopulmonary dysplasia; LUSC cis rs2346177 0.846 rs6714738 chr2:46646164 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.56 -8.73 -0.43 1.2e-16 HDL cholesterol; LUSC trans rs61931739 0.534 rs1490113 chr12:34132394 A/G cg26384229 chr12:38710491 ALG10B 0.72 11.42 0.53 1.02e-25 Morning vs. evening chronotype; LUSC cis rs728616 0.558 rs35547640 chr10:82139150 C/T cg05935833 chr10:81318306 SFTPA2 -0.43 -5.87 -0.31 1.08e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs516243 0.841 rs6540944 chr1:10740405 C/T cg02903756 chr1:10750680 CASZ1 -0.51 -9.11 -0.45 7.87e-18 Migraine - clinic-based; LUSC cis rs6750047 0.605 rs1374191 chr2:38265420 T/G cg07380506 chr2:38303506 CYP1B1 -0.45 -6.28 -0.33 1.02e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg04362960 chr10:104952993 NT5C2 0.5 6.29 0.33 9.94e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9815354 1.000 rs2128834 chr3:41862645 A/G cg03022575 chr3:42003672 ULK4 0.56 6.7 0.34 8.72e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs11105298 0.891 rs10858869 chr12:89857611 C/T cg00757033 chr12:89920650 WDR51B 0.6 10.33 0.49 7.01e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6681460 1.000 rs6680876 chr1:67129482 G/A cg02459107 chr1:67143332 SGIP1 0.48 9.04 0.44 1.34e-17 Presence of antiphospholipid antibodies; LUSC cis rs9311676 0.656 rs55964615 chr3:58389120 A/T cg26110898 chr3:58419937 PDHB 0.4 6.53 0.34 2.4e-10 Systemic lupus erythematosus; LUSC cis rs7394579 1 rs7394579 chr11:61581450 A/G cg19610905 chr11:61596333 FADS2 -0.54 -7.61 -0.38 2.85e-13 Red cell distribution width;Mean platelet volume; LUSC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg11764359 chr7:65958608 NA -0.68 -10.52 -0.5 1.53e-22 Aortic root size; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg06873352 chr17:61820015 STRADA 0.7 12.1 0.55 3.36e-28 Prudent dietary pattern; LUSC cis rs3771570 1.000 rs62193202 chr2:242303717 G/A cg21155796 chr2:242212141 HDLBP 0.62 6.67 0.34 1.07e-10 Prostate cancer; LUSC cis rs870825 0.616 rs28672716 chr4:185647345 G/A cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg16524733 chr11:117070046 TAGLN 0.42 7.19 0.37 4.35e-12 Blood protein levels; LUSC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 14.99 0.63 3.42e-39 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.69 -0.34 9.34e-11 Lung cancer; LUSC cis rs1018836 0.828 rs7816023 chr8:91567398 T/C cg16814680 chr8:91681699 NA -0.69 -11.11 -0.52 1.28e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs3942852 0.868 rs10769315 chr11:48110367 A/G cg20307385 chr11:47447363 PSMC3 0.54 6.28 0.33 1.04e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6541297 0.699 rs4846916 chr1:230296492 G/A cg05784532 chr1:230284198 GALNT2 0.58 6.68 0.34 9.94e-11 Coronary artery disease; LUSC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.33 0.62 1.18e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs597583 0.709 rs7940527 chr11:117398202 C/G cg27161313 chr11:117392002 DSCAML1 0.38 6.7 0.34 9.04e-11 Putamen volume; LUSC cis rs9916302 0.706 rs9906612 chr17:37547631 A/C cg07936489 chr17:37558343 FBXL20 0.8 9.91 0.48 1.86e-20 Glomerular filtration rate (creatinine); LUSC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg14584255 chr6:163149320 PACRG;PARK2 -0.39 -7.57 -0.38 3.79e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 14.39 0.62 7.35e-37 Platelet count; LUSC cis rs1670533 1.000 rs6599278 chr4:1058798 C/T cg27284194 chr4:1044797 NA 0.56 7.73 0.39 1.31e-13 Recombination rate (females); LUSC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg14403583 chr14:105418241 AHNAK2 -0.59 -9.83 -0.47 3.42e-20 Rheumatoid arthritis; LUSC cis rs6961069 0.745 rs13233631 chr7:80270822 A/G cg04458919 chr7:80252533 CD36 0.35 6.27 0.32 1.09e-9 Platelet count; LUSC cis rs679087 1.000 rs302321 chr12:29928388 A/C cg14258853 chr12:29935411 TMTC1 1.0 17.66 0.69 9.56e-50 Schizophrenia; LUSC cis rs6494488 0.500 rs72744722 chr15:65020453 C/A cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs826838 0.620 rs11614695 chr12:39331847 C/T cg26384229 chr12:38710491 ALG10B 0.76 12.49 0.56 1.28e-29 Heart rate; LUSC cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.73 0.35 7.22e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg09034736 chr1:150693464 HORMAD1 0.46 6.71 0.34 8.14e-11 Melanoma; LUSC cis rs4363385 0.818 rs6587719 chr1:152993409 G/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.5 -0.38 5.84e-13 Inflammatory skin disease; LUSC cis rs61990749 0.597 rs2299930 chr14:78163722 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.54 -5.85 -0.3 1.16e-8 Fibroblast growth factor basic levels; LUSC cis rs951366 0.576 rs11240559 chr1:205709621 T/G cg24503407 chr1:205819492 PM20D1 -0.48 -6.37 -0.33 6.13e-10 Menarche (age at onset); LUSC cis rs7615316 0.779 rs7627694 chr3:142100478 T/C cg16271453 chr3:142027066 XRN1 -0.41 -7.18 -0.37 4.48e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7085104 0.513 rs619824 chr10:104581288 G/T cg23093090 chr10:104574429 C10orf26 -0.49 -9.75 -0.47 6.13e-20 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg21643547 chr1:205240462 TMCC2 -0.49 -9.38 -0.46 1.03e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9388451 0.839 rs4897155 chr6:126095144 C/A cg05901451 chr6:126070800 HEY2 -0.95 -18.47 -0.71 5.46e-53 Brugada syndrome; LUSC cis rs737008 0.922 rs2550475 chr16:11371986 C/T cg00044050 chr16:11439710 C16orf75 0.57 8.92 0.44 3.03e-17 Obesity-related traits; LUSC cis rs8103278 1.000 rs725660 chr19:46262286 C/A cg14061069 chr19:46274453 DMPK -0.52 -8.99 -0.44 1.81e-17 Coronary artery disease; LUSC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg05738196 chr6:26577821 NA 0.53 8.32 0.41 2.23e-15 Schizophrenia; LUSC cis rs26868 0.766 rs30995 chr16:2248017 C/T cg07587117 chr16:2239488 CASKIN1 -0.31 -5.65 -0.3 3.42e-8 Height; LUSC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg06634786 chr22:41940651 POLR3H 0.51 6.11 0.32 2.82e-9 Vitiligo; LUSC cis rs2115536 1.000 rs11637477 chr15:80193295 C/T cg00225070 chr15:80189496 MTHFS 0.61 9.44 0.46 6.63e-19 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg03806693 chr22:41940476 POLR3H 0.88 12.29 0.56 7.03e-29 Vitiligo; LUSC trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg06636001 chr8:8085503 FLJ10661 0.57 8.45 0.42 8.93e-16 Retinal vascular caliber; LUSC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg20295408 chr7:1910781 MAD1L1 -0.45 -6.17 -0.32 1.94e-9 Bipolar disorder and schizophrenia; LUSC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.93 0.4 3.38e-14 Hemoglobin concentration; LUSC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg09640425 chr7:158790006 NA -0.4 -6.19 -0.32 1.78e-9 Facial morphology (factor 20); LUSC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg14552801 chr7:65878734 NA -0.46 -6.34 -0.33 7.34e-10 Aortic root size; LUSC cis rs13082711 0.522 rs578501 chr3:27344963 A/G cg02860705 chr3:27208620 NA 0.46 8.37 0.42 1.57e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs9937943 0.673 rs12922972 chr16:74494522 T/A cg01733217 chr16:74700730 RFWD3 0.58 6.49 0.33 3.11e-10 Neutrophil percentage of white cells; LUSC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg00129232 chr17:37814104 STARD3 -0.49 -7.38 -0.37 1.23e-12 Asthma; LUSC cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.59 -8.45 -0.42 9.42e-16 Monocyte percentage of white cells; LUSC cis rs9467773 1.000 rs10946835 chr6:26533757 C/T cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.86e-18 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.645 rs7123448 chr11:49764865 T/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.94 -0.72 7.57e-55 Height; LUSC trans rs11165623 0.740 rs12126692 chr1:96889258 C/G cg10631902 chr5:14652156 NA 0.54 8.77 0.43 9.45e-17 Hip circumference;Waist circumference; LUSC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg07777115 chr5:623756 CEP72 -0.47 -5.77 -0.3 1.78e-8 Lung disease severity in cystic fibrosis; LUSC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg17264618 chr3:40429014 ENTPD3 0.3 6.18 0.32 1.85e-9 Renal cell carcinoma; LUSC trans rs10511400 0.618 rs6438566 chr3:119870789 T/C cg02809009 chr19:50354510 PTOV1 -0.68 -6.19 -0.32 1.81e-9 Economic and political preferences (feminism/equality); LUSC cis rs6977660 0.714 rs10249477 chr7:19805388 T/A cg07541023 chr7:19748670 TWISTNB 0.64 6.92 0.35 2.28e-11 Thyroid stimulating hormone; LUSC trans rs7939886 0.920 rs1586014 chr11:55771540 C/T cg15704280 chr7:45808275 SEPT13 0.85 7.39 0.37 1.21e-12 Myopia (pathological); LUSC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg12311346 chr5:56204834 C5orf35 -0.84 -13.02 -0.58 1.29e-31 Initial pursuit acceleration; LUSC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg18230493 chr5:56204884 C5orf35 -0.57 -9.1 -0.45 8.19e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.73 0.6 2.45e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg23131131 chr22:24373011 LOC391322 -0.49 -7.07 -0.36 8.9e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9473147 0.543 rs9381578 chr6:47556634 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.75 0.3 2.07e-8 Platelet distribution width;Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15099667 chr2:219134699 PNKD;AAMP 0.49 6.73 0.35 7.29e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg26769984 chr7:1090371 C7orf50 0.71 10.21 0.49 1.79e-21 Bronchopulmonary dysplasia; LUSC cis rs7829975 0.577 rs940030 chr8:8546928 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.25 -0.32 1.26e-9 Mood instability; LUSC cis rs11098499 0.619 rs28502463 chr4:120257023 T/C cg09307838 chr4:120376055 NA 0.69 10.47 0.5 2.2e-22 Corneal astigmatism; LUSC cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg04586622 chr2:25135609 ADCY3 0.32 6.18 0.32 1.92e-9 Body mass index; LUSC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg11812906 chr14:75593930 NEK9 0.66 11.31 0.53 2.47e-25 Height; LUSC cis rs983392 0.709 rs7932740 chr11:59976111 G/A cg20284999 chr11:59952153 MS4A6A -0.38 -6.24 -0.32 1.29e-9 Alzheimer's disease (late onset); LUSC cis rs6489882 0.703 rs10774671 chr12:113357193 G/A cg20102336 chr12:113376681 OAS3 -0.39 -5.77 -0.3 1.82e-8 Chronic lymphocytic leukemia; LUSC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg24531977 chr5:56204891 C5orf35 0.61 9.15 0.45 5.56e-18 Coronary artery disease; LUSC cis rs5753037 0.702 rs140100 chr22:30128240 C/T cg01021169 chr22:30184971 ASCC2 -0.34 -5.77 -0.3 1.85e-8 Type 1 diabetes; LUSC cis rs9479482 0.935 rs563278 chr6:150364427 G/C cg25797454 chr6:150327115 RAET1K 0.33 7.5 0.38 5.67e-13 Alopecia areata; LUSC trans rs7618501 0.633 rs7628058 chr3:50039474 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.58 9.64 0.47 1.41e-19 Intelligence (multi-trait analysis); LUSC cis rs6977660 0.714 rs10252965 chr7:19822385 A/C cg07541023 chr7:19748670 TWISTNB 0.58 6.24 0.32 1.34e-9 Thyroid stimulating hormone; LUSC cis rs11250464 0.833 rs4554799 chr10:1407728 C/T cg26394196 chr10:1453818 ADARB2 -0.39 -6.7 -0.34 8.94e-11 Radiation response; LUSC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg13390004 chr1:15929781 NA 0.41 6.85 0.35 3.63e-11 Systolic blood pressure; LUSC cis rs4566357 1.000 rs2177598 chr2:227922900 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg02079420 chr8:82753780 SNX16 0.38 5.79 0.3 1.6e-8 Diastolic blood pressure; LUSC cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg22601191 chr20:60968625 CABLES2 0.43 6.11 0.32 2.77e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03352830 chr11:487213 PTDSS2 0.66 8.44 0.42 1e-15 Body mass index; LUSC cis rs17253792 0.822 rs28409547 chr14:56047826 C/T cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs877282 0.947 rs4133015 chr10:774131 T/C cg17470449 chr10:769945 NA 0.5 7.14 0.36 5.94e-12 Uric acid levels; LUSC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg17971929 chr21:40555470 PSMG1 -0.7 -11.5 -0.53 5e-26 Cognitive function; LUSC cis rs10450586 0.932 rs10767632 chr11:27318465 C/G cg08958251 chr11:27270390 NA 0.35 5.75 0.3 2.07e-8 Total body bone mineral density; LUSC cis rs11098499 0.954 rs2892848 chr4:120381341 C/T cg24375607 chr4:120327624 NA 0.78 11.63 0.54 1.74e-26 Corneal astigmatism; LUSC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.7 -0.34 8.72e-11 Tonsillectomy; LUSC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 9.66 0.47 1.21e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg05347473 chr6:146136440 FBXO30 0.53 9.23 0.45 3.29e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg13560548 chr3:10150139 C3orf24 0.55 7.84 0.39 6.05e-14 Alzheimer's disease; LUSC cis rs9467773 0.620 rs2504600 chr6:26648334 C/A cg05738196 chr6:26577821 NA 0.79 14.91 0.63 6.82e-39 Intelligence (multi-trait analysis); LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg17386128 chr2:173420391 PDK1 -0.41 -6.06 -0.31 3.77e-9 QT interval (ambient particulate matter interaction); LUSC trans rs225245 0.755 rs7217565 chr17:34024707 C/A cg19694781 chr19:47549865 TMEM160 -0.39 -6.2 -0.32 1.66e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs1997103 1.000 rs1997098 chr7:55405594 G/T cg20935933 chr6:143382018 AIG1 0.5 7.27 0.37 2.61e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg22907277 chr7:1156413 C7orf50 0.45 6.8 0.35 4.95e-11 Longevity;Endometriosis; LUSC cis rs2235649 0.663 rs6600168 chr16:1848927 C/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -5.96 -0.31 6.24e-9 Blood metabolite levels; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg16145915 chr7:1198662 ZFAND2A -0.65 -12.59 -0.57 5.4e-30 Longevity;Endometriosis; LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.52 7.27 0.37 2.56e-12 Gut microbiome composition (summer); LUSC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg25072359 chr17:41440525 NA 0.6 8.57 0.42 4.01e-16 Menopause (age at onset); LUSC cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg26384229 chr12:38710491 ALG10B 0.89 14.82 0.63 1.52e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg23711669 chr6:146136114 FBXO30 0.84 15.31 0.64 1.92e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg20744362 chr22:50050164 C22orf34 -0.37 -7.8 -0.39 8.18e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg26395211 chr5:140044315 WDR55 0.45 7.01 0.36 1.29e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs7572644 0.640 rs4564736 chr2:28069543 A/T cg27432699 chr2:27873401 GPN1 0.51 6.96 0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg23711669 chr6:146136114 FBXO30 0.88 16.15 0.66 9.46e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg04063615 chr12:132293388 NA -0.36 -5.99 -0.31 5.3e-9 Migraine; LUSC cis rs68092024 0.731 rs792841 chr3:99471308 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 6.38 0.33 5.94e-10 Cleft lip with or without cleft palate; LUSC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg24562669 chr7:97807699 LMTK2 0.4 7.0 0.36 1.43e-11 Breast cancer; LUSC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg11764359 chr7:65958608 NA 0.55 7.32 0.37 1.81e-12 Aortic root size; LUSC cis rs7760949 0.889 rs9475807 chr6:13934597 T/C cg27413430 chr6:13925136 RNF182 0.61 8.94 0.44 2.64e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.71 -9.27 -0.45 2.35e-18 Gut microbiome composition (summer); LUSC cis rs10504229 0.500 rs9772760 chr8:57986999 G/C cg22535103 chr8:58192502 C8orf71 -0.48 -6.46 -0.33 3.76e-10 Developmental language disorder (linguistic errors); LUSC cis rs73200209 0.744 rs61939680 chr12:116493867 G/A cg01776926 chr12:116560359 MED13L -0.5 -5.94 -0.31 7.14e-9 Total body bone mineral density; LUSC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.38 -5.78 -0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.28e-9 Menopause (age at onset); LUSC cis rs11098499 0.954 rs9685777 chr4:120365965 C/A cg09307838 chr4:120376055 NA 0.77 11.16 0.52 8.86e-25 Corneal astigmatism; LUSC trans rs7980799 0.649 rs2220059 chr12:33648630 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.95 -0.31 6.71e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs7712401 0.601 rs246320 chr5:122308581 A/G cg19077854 chr5:122220652 SNX24 0.44 9.77 0.47 5.19e-20 Mean platelet volume; LUSC cis rs6500602 1.000 rs12447826 chr16:4464617 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.44 5.77 0.3 1.82e-8 Schizophrenia; LUSC cis rs1858037 0.867 rs871974 chr2:65557287 C/T cg08085232 chr2:65598271 SPRED2 0.43 6.58 0.34 1.83e-10 Rheumatoid arthritis; LUSC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg14298792 chr15:30685198 CHRFAM7A -0.5 -6.06 -0.31 3.72e-9 Huntington's disease progression; LUSC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.83 0.3 1.3e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg27170947 chr2:26402098 FAM59B 0.73 10.81 0.51 1.45e-23 Gut microbiome composition (summer); LUSC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg18230493 chr5:56204884 C5orf35 -0.86 -13.12 -0.58 5.35e-32 Initial pursuit acceleration; LUSC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg05393297 chr12:53359155 NA -0.73 -11.3 -0.53 2.71e-25 Cancer (pleiotropy); LUSC cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg13010199 chr12:38710504 ALG10B 0.68 10.62 0.5 6.57e-23 Bladder cancer; LUSC trans rs12210905 0.925 rs11966939 chr6:27003749 T/C cg11837749 chr1:55047332 ACOT11 0.59 6.3 0.33 9.16e-10 Hip circumference adjusted for BMI; LUSC cis rs7005380 0.556 rs35362581 chr8:120933868 G/C cg21744203 chr8:120868354 DSCC1 0.48 5.85 0.3 1.2e-8 Interstitial lung disease; LUSC cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg11058730 chr11:34937778 PDHX;APIP 0.71 11.55 0.53 3.34e-26 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.81 12.23 0.56 1.16e-28 Cognitive test performance; LUSC cis rs870825 0.860 rs72689297 chr4:185600957 A/T cg04058563 chr4:185651563 MLF1IP 0.83 11.65 0.54 1.45e-26 Blood protein levels; LUSC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg05340658 chr4:99064831 C4orf37 0.68 11.4 0.53 1.23e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs62056376 0.607 rs7213556 chr17:32592915 C/A cg19986872 chr5:131347773 ACSL6 -0.38 -5.98 -0.31 5.65e-9 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs9905704 0.633 rs8068455 chr17:56589381 C/T cg19466818 chr17:56409534 MIR142 0.37 6.89 0.35 2.72e-11 Testicular germ cell tumor; LUSC cis rs4285028 0.747 rs11916169 chr3:121403211 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.85 -0.58 5.56e-31 Multiple sclerosis; LUSC cis rs1801251 0.778 rs2250654 chr2:233752376 A/T cg25237894 chr2:233734115 C2orf82 -0.37 -6.87 -0.35 3.15e-11 Coronary artery disease; LUSC trans rs6502050 0.835 rs28481866 chr17:80105160 G/A cg07393940 chr7:158741817 NA 0.36 6.57 0.34 1.98e-10 Life satisfaction; LUSC cis rs9300255 0.602 rs2851450 chr12:123703501 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs1941023 0.584 rs10750937 chr11:60172087 C/T cg08716584 chr11:60157161 MS4A7 -0.62 -11.34 -0.53 2.02e-25 Congenital heart disease (maternal effect); LUSC cis rs10905065 0.829 rs2246399 chr10:5799286 T/A cg11519256 chr10:5708881 ASB13 -0.41 -5.93 -0.31 7.45e-9 Menopause (age at onset); LUSC cis rs4664304 0.658 rs2667012 chr2:160867553 G/T cg03641300 chr2:160917029 PLA2R1 -0.36 -6.05 -0.31 3.87e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1595825 0.891 rs10497810 chr2:198895732 C/T cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 1.000 rs2245054 chr15:43751909 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.82 -0.39 7.14e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg14668632 chr7:2872130 GNA12 -0.42 -6.2 -0.32 1.69e-9 Height; LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4820539 1.000 rs885964 chr22:23461003 G/C cg14186256 chr22:23484241 RTDR1 0.97 18.01 0.7 3.7700000000000003e-51 Bone mineral density; LUSC cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg13010199 chr12:38710504 ALG10B 0.7 10.68 0.5 4.37e-23 Bladder cancer; LUSC cis rs3806843 1.000 rs10053586 chr5:140210760 T/C cg19875535 chr5:140030758 IK 0.51 8.18 0.41 5.84e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs73206853 0.841 rs73191825 chr12:110942205 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.45 -9.43 -0.46 7.23e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs4629710 0.534 rs6916881 chr6:131565153 C/T cg12700074 chr6:131571435 AKAP7 -0.35 -5.86 -0.31 1.13e-8 Multiple myeloma (IgH translocation); LUSC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.71 0.3 2.52e-8 Cerebrospinal P-tau181p levels; LUSC cis rs7246967 0.673 rs35007247 chr19:22822923 C/T cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs6063312 1.000 rs6095261 chr20:47346494 C/A cg18078177 chr20:47281410 PREX1 0.6 7.18 0.37 4.55e-12 Tonometry; LUSC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg00484396 chr16:3507460 NAT15 -0.46 -7.58 -0.38 3.53e-13 Body mass index (adult); LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03934478 chr11:495069 RNH1 0.82 9.89 0.48 2.07e-20 Body mass index; LUSC cis rs709400 0.628 rs11622356 chr14:103912195 C/T cg24130564 chr14:104152367 KLC1 -0.45 -6.22 -0.32 1.45e-9 Body mass index; LUSC cis rs12541635 0.677 rs2029879 chr8:107024695 T/A cg10147462 chr8:107024639 NA 0.68 14.15 0.61 5.93e-36 Age of smoking initiation; LUSC cis rs10744422 1.000 rs897386 chr12:123341289 A/C cg25930673 chr12:123319894 HIP1R -0.66 -6.46 -0.33 3.65e-10 Schizophrenia; LUSC cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg23158103 chr7:148848205 ZNF398 -0.43 -6.78 -0.35 5.4e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg11663144 chr21:46675770 NA -0.39 -6.83 -0.35 4.14e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.51 7.25 0.37 2.87e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs34638657 0.732 rs12597010 chr16:82199971 G/A cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.55e-10 Lung adenocarcinoma; LUSC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg13319975 chr6:146136371 FBXO30 -0.68 -10.22 -0.49 1.58e-21 Lobe attachment (rater-scored or self-reported); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg06127414 chr17:1179309 NA -0.37 -6.39 -0.33 5.47e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs13089785 1.000 rs2332682 chr3:123654633 C/T cg20230305 chr3:123418791 MYLK 0.36 6.0 0.31 5.17e-9 Intelligence (multi-trait analysis); LUSC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg07395648 chr5:131743802 NA -0.42 -6.91 -0.35 2.42e-11 Breast cancer;Mosquito bite size; LUSC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg17366294 chr4:99064904 C4orf37 0.57 10.05 0.48 6.03e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs739401 0.527 rs418832 chr11:3072236 C/T cg08508325 chr11:3079039 CARS -0.54 -13.66 -0.6 4.64e-34 Longevity; LUSC cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -8.97 -0.44 2.24e-17 Chronic sinus infection; LUSC cis rs7937682 0.883 rs1612013 chr11:111456293 A/G cg09085632 chr11:111637200 PPP2R1B -1.01 -15.59 -0.65 1.42e-41 Primary sclerosing cholangitis; LUSC cis rs7100689 0.516 rs10788546 chr10:82034854 T/C cg01528321 chr10:82214614 TSPAN14 0.84 12.2 0.56 1.44e-28 Post bronchodilator FEV1; LUSC cis rs977987 0.654 rs8054194 chr16:75497160 G/T cg03315344 chr16:75512273 CHST6 0.51 9.38 0.46 1.04e-18 Dupuytren's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14608199 chr11:2949963 PHLDA2 0.38 6.05 0.31 3.86e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg25072359 chr17:41440525 NA 0.66 9.28 0.45 2.14e-18 Menopause (age at onset); LUSC cis rs253664 0.897 rs1199328 chr3:138112107 G/A cg25188949 chr3:137893707 DBR1 -0.49 -5.91 -0.31 8.26e-9 Body mass index; LUSC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg20135002 chr11:47629003 NA -0.51 -7.98 -0.4 2.41e-14 Subjective well-being; LUSC cis rs72634258 0.786 rs9434992 chr1:8179392 G/T cg26816564 chr1:7831052 VAMP3 0.47 6.17 0.32 1.92e-9 Inflammatory bowel disease; LUSC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg20573242 chr4:122745356 CCNA2 0.63 9.38 0.46 1.06e-18 Type 2 diabetes; LUSC cis rs6733011 0.644 rs6719634 chr2:99460614 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.41 -5.67 -0.3 3.07e-8 Bipolar disorder; LUSC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg12560992 chr17:57184187 TRIM37 0.8 14.01 0.61 2.07e-35 Intelligence (multi-trait analysis); LUSC cis rs7577696 0.785 rs11683842 chr2:32364131 G/A cg02381751 chr2:32503542 YIPF4 -0.44 -6.22 -0.32 1.53e-9 Inflammatory biomarkers; LUSC cis rs6754311 0.678 rs309181 chr2:136614813 C/G cg07169764 chr2:136633963 MCM6 -0.6 -8.05 -0.4 1.47e-14 Mosquito bite size; LUSC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs8008758 1.000 rs12432879 chr14:101688977 A/G cg26224664 chr14:101693935 NA 0.26 5.66 0.3 3.33e-8 Body mass index (alcohol intake interaction); LUSC cis rs2777491 0.915 rs28583065 chr15:41608470 T/C cg18705301 chr15:41695430 NDUFAF1 -0.76 -13.71 -0.6 3e-34 Ulcerative colitis; LUSC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg18230493 chr5:56204884 C5orf35 -0.76 -9.0 -0.44 1.81e-17 Type 2 diabetes; LUSC cis rs7940866 0.834 rs1594821 chr11:130835883 C/T cg12179176 chr11:130786555 SNX19 0.52 7.81 0.39 7.61e-14 Schizophrenia; LUSC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg09877947 chr5:131593287 PDLIM4 -0.47 -6.69 -0.34 9.34e-11 Breast cancer; LUSC cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -7.47 -0.38 7.17e-13 Chronic sinus infection; LUSC cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg08999081 chr20:33150536 PIGU -0.41 -7.56 -0.38 3.88e-13 Glomerular filtration rate (creatinine); LUSC cis rs2273669 0.667 rs75263286 chr6:109350489 G/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 9.1e-9 Prostate cancer; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg23981150 chr1:161111090 NA -0.4 -6.06 -0.31 3.71e-9 N-glycan levels; LUSC cis rs73206853 0.841 rs73191836 chr12:110966177 G/T cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7100689 0.646 rs1815650 chr10:82157464 C/T cg00277334 chr10:82204260 NA -0.49 -7.15 -0.36 5.4e-12 Post bronchodilator FEV1; LUSC cis rs10489202 1.000 rs17556487 chr1:167889094 T/A cg24449463 chr1:168025552 DCAF6 -0.55 -6.69 -0.34 9.61e-11 Schizophrenia; LUSC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.6 8.43 0.42 1.05e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6967385 0.519 rs7795828 chr7:12347689 C/T cg10578991 chr7:12443926 VWDE 0.41 6.04 0.31 4.04e-9 Response to taxane treatment (placlitaxel); LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 5.1e-14 Prudent dietary pattern; LUSC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg02269571 chr22:50332266 NA -0.55 -8.22 -0.41 4.59e-15 Schizophrenia; LUSC cis rs2760061 0.603 rs697762 chr1:228192410 G/A cg02753203 chr1:228287806 NA 0.88 17.08 0.68 1.87e-47 Diastolic blood pressure; LUSC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg12011299 chr4:100065546 ADH4 0.68 10.29 0.49 9.06e-22 Smoking initiation; LUSC cis rs11785400 0.731 rs4294163 chr8:143730830 G/T cg24634471 chr8:143751801 JRK 0.51 7.25 0.37 2.97e-12 Schizophrenia; LUSC cis rs8017423 0.647 rs12883844 chr14:90820519 T/C cg04374321 chr14:90722782 PSMC1 -0.44 -6.63 -0.34 1.34e-10 Mortality in heart failure; LUSC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg24154853 chr7:158122151 PTPRN2 0.45 8.9 0.44 3.74e-17 Calcium levels; LUSC cis rs8141529 0.719 rs6005916 chr22:29233342 T/C cg15103426 chr22:29168792 CCDC117 0.6 8.45 0.42 8.82e-16 Lymphocyte counts; LUSC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg24209194 chr3:40518798 ZNF619 0.47 6.67 0.34 1.07e-10 Renal cell carcinoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07481335 chr14:65879396 FUT8;LOC645431 -0.42 -6.31 -0.33 8.81e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2348418 0.864 rs7957495 chr12:28717455 C/G cg13890972 chr12:28721907 NA 0.34 5.98 0.31 5.62e-9 Lung function (FVC);Lung function (FEV1); LUSC trans rs4332037 0.906 rs62442903 chr7:1953416 G/A cg10840412 chr1:235813424 GNG4 0.64 8.78 0.43 8.41e-17 Bipolar disorder; LUSC trans rs9409565 0.658 rs2809768 chr9:97128369 G/A cg05679027 chr9:99775184 HIATL2 0.45 6.36 0.33 6.65e-10 Colorectal cancer (alcohol consumption interaction); LUSC cis rs9297145 0.585 rs62473049 chr7:98777685 T/C cg05967295 chr7:98741636 SMURF1 -0.64 -9.99 -0.48 9.74e-21 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs6547741 1.000 rs1919125 chr2:27801403 C/G cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 3.04e-39 Oral cavity cancer; LUSC cis rs67072384 0.792 rs7936968 chr11:72479681 T/C cg04827223 chr11:72435913 ARAP1 -0.87 -6.44 -0.33 4.27e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs2285002 0.579 rs4902317 chr14:65270024 A/G cg22491548 chr7:128000861 PRRT4 -0.27 -6.03 -0.31 4.43e-9 Red cell distribution width; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05602200 chr16:89307410 NA 0.7 6.07 0.32 3.48e-9 Cognitive performance; LUSC cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg06784218 chr1:46089804 CCDC17 -0.51 -9.79 -0.47 4.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.77 -0.43 9.5e-17 Axial length; LUSC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg08219700 chr8:58056026 NA -0.74 -8.77 -0.43 9.31e-17 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg18825119 chr6:163149453 PACRG;PARK2 -0.35 -6.2 -0.32 1.67e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs61142792 0.590 rs747861 chr5:177037397 C/G cg10940203 chr5:177434438 FAM153C 0.68 6.21 0.32 1.59e-9 Alzheimer disease and age of onset; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12112058 chr1:224622605 WDR26 0.41 6.02 0.31 4.63e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs35096708 1.000 rs35096708 chr16:89887249 G/A cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.48 -5.74 -0.3 2.11e-8 Skin aging (microtopography measurement); LUSC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg23283495 chr1:209979779 IRF6 0.63 7.81 0.39 7.65e-14 Cleft lip with or without cleft palate; LUSC cis rs7577696 0.597 rs212690 chr2:32437631 C/G cg02381751 chr2:32503542 YIPF4 0.53 6.84 0.35 3.76e-11 Inflammatory biomarkers; LUSC cis rs813218 0.585 rs9860514 chr3:99917359 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.31 -5.85 -0.3 1.18e-8 Orofacial clefts; LUSC cis rs1670533 1.000 rs10084890 chr4:1053934 C/G cg27284194 chr4:1044797 NA -0.56 -8.84 -0.44 5.75e-17 Recombination rate (females); LUSC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg12463550 chr7:65579703 CRCP 0.5 6.96 0.36 1.76e-11 Aortic root size; LUSC cis rs13394619 0.935 rs12468019 chr2:11725049 T/C cg07314298 chr2:11723111 GREB1 -0.58 -10.6 -0.5 8.34e-23 Endometriosis; LUSC cis rs4363385 0.818 rs441229 chr1:153015059 A/C cg25856811 chr1:152973957 SPRR3 -0.34 -5.79 -0.3 1.62e-8 Inflammatory skin disease; LUSC cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg25019033 chr10:957182 NA -0.53 -6.87 -0.35 3.13e-11 Eosinophil percentage of granulocytes; LUSC cis rs714027 1.000 rs6006356 chr22:30503171 G/A cg11564601 chr22:30592435 NA -0.37 -6.79 -0.35 5.22e-11 Lymphocyte counts; LUSC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg08219700 chr8:58056026 NA 0.72 8.47 0.42 8.07e-16 Developmental language disorder (linguistic errors); LUSC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg04511125 chr2:88470314 THNSL2 0.94 9.27 0.45 2.33e-18 Plasma clusterin levels; LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.85 -0.44 5.31e-17 Platelet count; LUSC cis rs597583 0.806 rs10892135 chr11:117392826 G/A cg27161313 chr11:117392002 DSCAML1 -0.43 -7.38 -0.37 1.25e-12 Putamen volume; LUSC cis rs7089973 0.966 rs55711292 chr10:116604870 T/G cg23260525 chr10:116636907 FAM160B1 0.37 7.19 0.37 4.21e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs611744 0.604 rs13248461 chr8:109285833 C/T cg18478394 chr8:109455254 TTC35 0.41 6.35 0.33 6.94e-10 Dupuytren's disease; LUSC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg13939156 chr17:80058883 NA -0.33 -6.41 -0.33 5.01e-10 Life satisfaction; LUSC trans rs4957048 0.577 rs56294732 chr5:568144 T/C cg25482853 chr8:67687455 SGK3 1.02 16.3 0.67 2.4e-44 Ulcerative colitis; LUSC cis rs9660992 0.548 rs1172152 chr1:205220718 T/A cg21643547 chr1:205240462 TMCC2 -0.49 -9.32 -0.45 1.63e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg22875332 chr1:76189707 ACADM -0.85 -17.64 -0.69 1.12e-49 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs72781680 1.000 rs72781634 chr2:24199102 C/T cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg06636001 chr8:8085503 FLJ10661 0.56 8.68 0.43 1.75e-16 Retinal vascular caliber; LUSC cis rs2625529 0.761 rs16956444 chr15:72271235 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.51 -0.38 5.46e-13 Red blood cell count; LUSC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg01448562 chr3:133502909 NA -0.65 -10.67 -0.5 4.48e-23 Iron status biomarkers; LUSC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg04369109 chr6:150039330 LATS1 -0.57 -8.31 -0.41 2.43e-15 Lung cancer; LUSC cis rs1865760 0.964 rs1324084 chr6:25915134 C/T cg16482183 chr6:26056742 HIST1H1C 0.44 6.46 0.33 3.77e-10 Height; LUSC cis rs6087771 0.682 rs2038397 chr20:30217759 A/G cg13852791 chr20:30311386 BCL2L1 0.81 10.69 0.51 3.75e-23 Subcortical brain region volumes;Putamen volume; LUSC cis rs4474465 1.000 rs2063727 chr11:78183882 T/A cg27205649 chr11:78285834 NARS2 -0.49 -5.84 -0.3 1.23e-8 Alzheimer's disease (survival time); LUSC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg21862992 chr11:68658383 NA 0.5 8.15 0.41 7.23e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.6 9.1 0.45 8.53e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4343996 0.754 rs7811286 chr7:3349521 C/T cg21248987 chr7:3385318 SDK1 -0.36 -6.19 -0.32 1.8e-9 Motion sickness; LUSC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg18904891 chr8:8559673 CLDN23 0.4 6.21 0.32 1.54e-9 Mood instability; LUSC cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg27446573 chr6:127587934 RNF146 0.64 9.72 0.47 7.68e-20 Breast cancer; LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg11494091 chr17:61959527 GH2 0.7 15.06 0.64 1.7e-39 Prudent dietary pattern; LUSC trans rs11165623 0.792 rs2104236 chr1:96908690 C/T cg10631902 chr5:14652156 NA -0.57 -9.25 -0.45 2.69e-18 Hip circumference;Waist circumference; LUSC cis rs644799 0.544 rs1527450 chr11:95467777 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.52 7.04 0.36 1.09e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.01 -0.44 1.65e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg24642439 chr20:33292090 TP53INP2 -0.57 -8.61 -0.43 2.97e-16 Height; LUSC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg20891558 chr2:74357851 NA 0.79 14.5 0.62 2.66e-37 Gestational age at birth (maternal effect); LUSC cis rs540254 0.578 rs4656271 chr1:160782942 A/G cg20255094 chr1:160771763 LY9 0.56 6.75 0.35 6.45e-11 Blood protein levels; LUSC cis rs12474201 0.822 rs897530 chr2:46948150 C/G cg06386533 chr2:46925753 SOCS5 0.71 10.49 0.5 1.97e-22 Height; LUSC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg27170947 chr2:26402098 FAM59B -0.63 -9.15 -0.45 5.98e-18 Gut microbiome composition (summer); LUSC cis rs6845621 0.901 rs12331873 chr4:18930586 C/A cg12196642 chr4:18937545 NA -0.37 -6.76 -0.35 6.21e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2228479 0.681 rs10153196 chr16:89967397 A/C cg06558623 chr16:89946397 TCF25 0.97 10.31 0.49 8.08e-22 Skin colour saturation; LUSC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg08048268 chr3:133502702 NA 0.46 9.17 0.45 5.05e-18 Iron status biomarkers; LUSC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg18681998 chr4:17616180 MED28 0.84 15.84 0.65 1.53e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg20607287 chr7:12443886 VWDE -0.65 -6.42 -0.33 4.74e-10 Coronary artery disease; LUSC trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg15704280 chr7:45808275 SEPT13 0.78 9.76 0.47 5.96e-20 Coronary artery disease; LUSC cis rs7402982 0.934 rs6598539 chr15:99204483 T/C cg03437748 chr15:99193247 IGF1R 0.54 8.5 0.42 6.32e-16 Birth weight; LUSC cis rs11098499 0.754 rs1511017 chr4:120250805 G/A cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs10927875 0.619 rs1806991 chr1:16129441 T/C cg22431228 chr1:16359049 CLCNKA 0.32 6.42 0.33 4.6e-10 Dilated cardiomyopathy; LUSC trans rs11098499 0.697 rs10016448 chr4:120298845 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs4478858 0.684 rs7521463 chr1:31761936 T/A cg00250761 chr1:31883323 NA -0.33 -7.95 -0.4 2.9e-14 Alcohol dependence; LUSC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg15369054 chr17:80825471 TBCD -0.36 -5.9 -0.31 8.93e-9 Breast cancer; LUSC trans rs2921073 0.509 rs2976931 chr8:8257317 C/A cg27411982 chr8:10470053 RP1L1 0.39 6.29 0.33 9.94e-10 Parkinson's disease; LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.3 0.33 9.19e-10 Bipolar disorder; LUSC cis rs62458065 0.640 rs4141788 chr7:32519264 T/C cg20159608 chr7:32802032 NA -0.71 -8.67 -0.43 1.9e-16 Metabolite levels (HVA/MHPG ratio); LUSC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg03929089 chr4:120376271 NA -1.03 -20.12 -0.74 1.48e-59 Height; LUSC cis rs10197940 0.648 rs7587301 chr2:152347600 A/G cg06191203 chr2:152266755 RIF1 -0.43 -6.02 -0.31 4.67e-9 Lung cancer; LUSC cis rs9399401 1.000 rs7756305 chr6:142670955 T/C cg03128060 chr6:142623767 GPR126 0.33 5.94 0.31 7.09e-9 Chronic obstructive pulmonary disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25333225 chr19:40791658 AKT2 0.5 7.64 0.39 2.3e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2439831 0.681 rs2278858 chr15:43632755 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.73 0.43 1.27e-16 Lung cancer in ever smokers; LUSC cis rs3858526 0.834 rs7125255 chr11:5980384 T/A cg13902645 chr11:5959945 NA -0.61 -8.48 -0.42 7.61e-16 DNA methylation (variation); LUSC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs807669 0.807 rs698422 chr22:19205826 A/T cg02655711 chr22:19163373 SLC25A1 0.76 14.74 0.63 3.11e-38 Metabolite levels; LUSC trans rs10221833 1.000 rs441414 chr2:165675693 A/G cg17870553 chr6:144292355 PLAGL1 0.62 6.06 0.31 3.63e-9 Response to statin therapy; LUSC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg01368799 chr11:117014884 PAFAH1B2 0.66 10.52 0.5 1.57e-22 Blood protein levels; LUSC cis rs11792861 0.926 rs118011482 chr9:111770626 G/C cg13535736 chr9:111863775 C9orf5 -0.43 -6.87 -0.35 3.15e-11 Menarche (age at onset); LUSC cis rs11650494 0.516 rs2233660 chr17:47492366 C/T cg08112188 chr17:47440006 ZNF652 -0.98 -7.96 -0.4 2.76e-14 Prostate cancer; LUSC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg00310523 chr12:86230176 RASSF9 0.45 8.31 0.41 2.43e-15 Major depressive disorder; LUSC cis rs10504229 0.679 rs16921676 chr8:58052386 G/T cg21724239 chr8:58056113 NA 0.6 7.11 0.36 7e-12 Developmental language disorder (linguistic errors); LUSC cis rs9814567 0.896 rs6790338 chr3:134208167 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.08 -0.61 1.1e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg24642439 chr20:33292090 TP53INP2 -0.5 -7.5 -0.38 5.92e-13 Glomerular filtration rate (creatinine); LUSC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg06634786 chr22:41940651 POLR3H 0.51 6.05 0.31 3.96e-9 Vitiligo; LUSC cis rs997295 0.713 rs10518739 chr15:68014971 A/G cg08079166 chr15:68083412 MAP2K5 0.33 6.56 0.34 1.99e-10 Motion sickness; LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.11 -0.58 5.82e-32 Platelet count; LUSC cis rs6964587 0.967 rs9656003 chr7:91766322 A/C cg17063962 chr7:91808500 NA 0.58 9.3 0.45 1.96e-18 Breast cancer; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs7927592 0.913 rs11228268 chr11:68287447 A/T cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.13e-9 Total body bone mineral density; LUSC cis rs7137828 0.837 rs653178 chr12:112007756 A/G cg10833066 chr12:111807467 FAM109A -0.33 -6.72 -0.35 7.87e-11 Glaucoma (primary open-angle);Coronary artery disease;Allergic disease (asthma, hay fever or eczema); LUSC cis rs3741151 0.892 rs76854106 chr11:73027110 G/A cg17517138 chr11:73019481 ARHGEF17 1.03 8.92 0.44 3.05e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4889609 0.834 rs72785520 chr16:31070778 C/T cg02466173 chr16:30829666 NA -0.5 -9.46 -0.46 5.63e-19 Response to metformin (IC50); LUSC cis rs11605924 1.000 rs11605924 chr11:45873091 A/C ch.11.939596F chr11:45881766 CRY2 -0.55 -8.32 -0.41 2.34e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.41 -0.42 1.21e-15 Lymphocyte counts; LUSC cis rs4746818 1.000 rs7916991 chr10:70895373 C/A cg11621586 chr10:70884670 VPS26A 1.14 10.89 0.51 7.61e-24 Left atrial antero-posterior diameter; LUSC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg16240275 chr20:61666158 NCRNA00029 0.41 9.04 0.44 1.29e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg12564285 chr5:131593104 PDLIM4 0.5 8.9 0.44 3.6e-17 Acylcarnitine levels; LUSC cis rs2274273 0.662 rs67958555 chr14:55670866 G/A cg04306507 chr14:55594613 LGALS3 0.47 9.24 0.45 3.04e-18 Protein biomarker; LUSC cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg01689657 chr7:91764605 CYP51A1 -0.33 -5.94 -0.31 7.11e-9 Breast cancer; LUSC cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg09184832 chr6:79620586 NA -0.42 -6.65 -0.34 1.19e-10 Intelligence (multi-trait analysis); LUSC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg05754148 chr16:3507555 NAT15 0.51 7.75 0.39 1.14e-13 Tuberculosis; LUSC cis rs17253792 0.822 rs10133962 chr14:56066088 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs27434 0.529 rs42443 chr5:96156224 G/A cg16492584 chr5:96139282 ERAP1 -0.57 -7.6 -0.38 3.1e-13 Ankylosing spondylitis; LUSC trans rs7944735 0.607 rs34895872 chr11:48021778 A/G cg15704280 chr7:45808275 SEPT13 0.55 6.53 0.34 2.45e-10 Intraocular pressure; LUSC cis rs6545883 0.929 rs6545873 chr2:61733012 T/C cg15711740 chr2:61764176 XPO1 -0.49 -7.78 -0.39 9.16e-14 Tuberculosis; LUSC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.57 -8.51 -0.42 6e-16 Menarche (age at onset); LUSC cis rs11190604 0.767 rs10883481 chr10:102165021 G/A cg07080220 chr10:102295463 HIF1AN 0.59 7.64 0.39 2.24e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs929354 1.000 rs1182381 chr7:157043473 G/A cg05182265 chr7:156933206 UBE3C 0.49 7.39 0.37 1.22e-12 Body mass index; LUSC cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg15691649 chr6:25882328 NA -0.38 -6.28 -0.32 1.06e-9 Blood metabolite levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05604720 chr8:90769698 RIPK2 0.47 6.37 0.33 6.31e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9818758 0.607 rs35108630 chr3:49088356 T/A cg00383909 chr3:49044727 WDR6 1.36 11.7 0.54 1.01e-26 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs13315871 1.000 rs9824965 chr3:58433505 T/A cg12435725 chr3:58293450 RPP14 -0.7 -6.93 -0.35 2.21e-11 Cholesterol, total; LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg10862848 chr6:42927986 GNMT -0.29 -7.04 -0.36 1.08e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg08027265 chr7:2291960 NA -0.37 -6.1 -0.32 3e-9 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg18477163 chr1:228402036 OBSCN -0.56 -10.38 -0.49 4.49e-22 Diastolic blood pressure; LUSC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 11.75 0.54 6.64e-27 Personality dimensions; LUSC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.53e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs8044995 0.563 rs8059585 chr16:68376811 G/A cg09835421 chr16:68378352 PRMT7 -0.76 -8.49 -0.42 7.06e-16 Schizophrenia; LUSC cis rs2777491 1.000 rs7167729 chr15:41721042 G/A cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.57 -0.6 1e-33 Ulcerative colitis; LUSC cis rs250677 0.522 rs3763022 chr5:148381078 A/G cg18129178 chr5:148520854 ABLIM3 -0.52 -8.08 -0.4 1.21e-14 Breast cancer; LUSC cis rs11711311 1.000 rs9811746 chr3:113515060 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.75 -0.3 1.97e-8 IgG glycosylation; LUSC trans rs61931739 0.649 rs864173 chr12:33721422 A/C cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg25036284 chr2:26402008 FAM59B -0.72 -9.96 -0.48 1.25e-20 Gut microbiome composition (summer); LUSC cis rs9372253 0.645 rs7753212 chr6:110700229 T/C cg01119278 chr6:110721349 DDO -0.44 -7.8 -0.39 7.79e-14 Platelet distribution width; LUSC cis rs9905704 0.589 rs2680696 chr17:56473013 C/T cg12560992 chr17:57184187 TRIM37 -0.5 -5.99 -0.31 5.45e-9 Testicular germ cell tumor; LUSC cis rs11997175 0.692 rs6468202 chr8:33747720 C/A ch.8.33884649F chr8:33765107 NA 0.52 8.04 0.4 1.6e-14 Body mass index; LUSC cis rs597583 0.806 rs4938397 chr11:117392337 G/T cg27161313 chr11:117392002 DSCAML1 -0.42 -7.25 -0.37 2.93e-12 Putamen volume; LUSC cis rs868036 0.681 rs4776977 chr15:68108219 C/T cg08079166 chr15:68083412 MAP2K5 0.41 7.29 0.37 2.33e-12 Restless legs syndrome; LUSC cis rs9323205 0.677 rs11620820 chr14:51734445 C/T cg23942311 chr14:51606299 NA -0.42 -8.02 -0.4 1.81e-14 Cancer; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg27535305 chr1:53392650 SCP2 -0.39 -7.46 -0.38 7.42e-13 Monocyte count; LUSC trans rs6601450 0.547 rs10105843 chr8:10197863 A/G cg06636001 chr8:8085503 FLJ10661 0.41 5.97 0.31 6.22e-9 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9399137 0.507 rs7754722 chr6:135260303 T/C cg22676075 chr6:135203613 NA -0.64 -9.83 -0.47 3.31e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13852536 chr9:32567045 NDUFB6 0.47 5.98 0.31 5.85e-9 Bipolar disorder and schizophrenia; LUSC cis rs7100689 0.646 rs1934692 chr10:82125734 C/A cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs4588572 0.643 rs1560196 chr5:77701982 G/C cg11547950 chr5:77652471 NA 0.51 7.37 0.37 1.33e-12 Triglycerides; LUSC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg18876405 chr7:65276391 NA -0.66 -11.66 -0.54 1.34e-26 Aortic root size; LUSC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg07936489 chr17:37558343 FBXL20 0.71 9.84 0.47 3.13e-20 Glomerular filtration rate (creatinine); LUSC trans rs9467711 0.606 rs13203358 chr6:26590578 A/T cg06606381 chr12:133084897 FBRSL1 -0.67 -6.7 -0.34 8.95e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs2019216 0.542 rs2221893 chr17:21930012 A/G cg22648282 chr17:21454238 C17orf51 -0.53 -7.98 -0.4 2.44e-14 Pelvic organ prolapse; LUSC cis rs909341 0.909 rs2257440 chr20:62328267 C/T cg09650180 chr20:62225654 GMEB2 -0.45 -5.94 -0.31 7.04e-9 Atopic dermatitis; LUSC cis rs12681287 0.517 rs7462883 chr8:87526790 G/A cg27223183 chr8:87520930 FAM82B -0.53 -7.04 -0.36 1.1e-11 Caudate activity during reward; LUSC cis rs4478858 0.684 rs7549343 chr1:31752260 A/G cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg18681998 chr4:17616180 MED28 0.84 15.65 0.65 8.27e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10782582 0.609 rs5745394 chr1:76311731 G/A cg03433033 chr1:76189801 ACADM -0.43 -6.39 -0.33 5.51e-10 Daytime sleep phenotypes; LUSC cis rs4903214 0.895 rs12433272 chr14:74715250 C/T cg08255017 chr14:74727001 VSX2 -0.48 -6.49 -0.33 3.09e-10 Inflammatory bowel disease; LUSC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 9.17 0.45 5.09e-18 Menopause (age at onset); LUSC cis rs10782582 0.593 rs11163904 chr1:76121208 A/G cg22875332 chr1:76189707 ACADM 0.41 6.28 0.32 1.05e-9 Daytime sleep phenotypes; LUSC trans rs1814175 0.817 rs11040700 chr11:50023832 C/T cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC trans rs1814175 0.500 rs1825677 chr11:49233099 T/G cg03929089 chr4:120376271 NA -0.66 -9.53 -0.46 3.47e-19 Height; LUSC cis rs17270561 0.583 rs7749149 chr6:25781139 G/A cg16482183 chr6:26056742 HIST1H1C 0.54 7.68 0.39 1.82e-13 Iron status biomarkers; LUSC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.43 -0.38 9.09e-13 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg08623948 chr7:23221430 NUPL2 0.4 6.15 0.32 2.16e-9 Triglycerides; LUSC cis rs9300255 0.602 rs1790095 chr12:123681222 G/A cg00376283 chr12:123451042 ABCB9 0.65 8.18 0.41 6.03e-15 Neutrophil percentage of white cells; LUSC cis rs2067615 0.579 rs7975576 chr12:107132501 A/G cg15890332 chr12:107067104 RFX4 0.34 6.14 0.32 2.4e-9 Heart rate; LUSC cis rs7246657 0.943 rs10409204 chr19:37917692 G/A cg23950597 chr19:37808831 NA -0.65 -7.77 -0.39 9.66e-14 Coronary artery calcification; LUSC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12756686 chr19:29218302 NA 0.67 9.61 0.47 1.85e-19 Methadone dose in opioid dependence; LUSC cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg03264133 chr6:25882463 NA 0.64 10.73 0.51 2.83e-23 Blood metabolite levels; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg21548813 chr6:291882 DUSP22 -0.51 -7.8 -0.39 7.73e-14 Menopause (age at onset); LUSC trans rs629535 0.735 rs525610 chr8:70074535 A/G cg21567404 chr3:27674614 NA 0.97 15.59 0.65 1.44e-41 Dupuytren's disease; LUSC cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg11584989 chr19:19387371 SF4 -0.52 -6.16 -0.32 2.05e-9 Bipolar disorder; LUSC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs9933309 1.000 rs9933309 chr16:88844932 A/G cg04602696 chr16:88846723 FAM38A -0.46 -9.43 -0.46 7.08e-19 Glycated hemoglobin levels; LUSC cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg21573476 chr21:45109991 RRP1B -0.36 -5.75 -0.3 2.01e-8 Mean corpuscular volume; LUSC cis rs476633 0.691 rs28735224 chr15:41537539 C/T cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.36 -0.42 1.75e-15 Glomerular filtration rate (creatinine); LUSC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg05973401 chr12:123451056 ABCB9 -0.46 -6.49 -0.33 3.08e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs240764 0.817 rs12199888 chr6:101154419 T/A cg09795085 chr6:101329169 ASCC3 -0.41 -6.02 -0.31 4.68e-9 Neuroticism; LUSC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg05872129 chr22:39784769 NA -0.58 -9.97 -0.48 1.18e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11785400 1.000 rs4736342 chr8:143735190 A/G cg10596483 chr8:143751796 JRK 0.61 9.38 0.46 1.04e-18 Schizophrenia; LUSC trans rs4714291 0.963 rs4714293 chr6:40009566 T/C cg02267698 chr19:7991119 CTXN1 0.52 7.3 0.37 2.19e-12 Strep throat; LUSC cis rs4319547 0.695 rs6489002 chr12:122929822 T/C cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.53 -0.42 5.32e-16 Body mass index; LUSC cis rs600231 0.571 rs10896000 chr11:65218018 A/G cg17120908 chr11:65337727 SSSCA1 -0.52 -9.04 -0.44 1.33e-17 Bone mineral density; LUSC cis rs751728 0.965 rs9394165 chr6:33731408 G/A cg25922239 chr6:33757077 LEMD2 0.53 8.04 0.4 1.61e-14 Crohn's disease; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg08128228 chr1:167191360 POU2F1 0.35 5.97 0.31 6.11e-9 Calcium levels; LUSC cis rs2204008 0.606 rs6582502 chr12:38543352 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.16 -0.41 6.75e-15 Bladder cancer; LUSC cis rs711244 0.783 rs2110944 chr2:37090233 T/C cg14987922 chr2:37194071 STRN -0.45 -6.58 -0.34 1.84e-10 Mean platelet volume; LUSC cis rs10089 1.000 rs1559263 chr5:127512873 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.85 11.53 0.53 4.22e-26 Ileal carcinoids; LUSC cis rs929354 0.772 rs6459738 chr7:156998532 T/G cg05182265 chr7:156933206 UBE3C -0.6 -9.63 -0.47 1.63e-19 Body mass index; LUSC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg02038168 chr22:39784481 NA -0.48 -7.87 -0.4 4.98e-14 Intelligence (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04741861 chr19:3531604 FZR1 -0.38 -6.18 -0.32 1.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11098499 0.909 rs28714195 chr4:120316950 A/T cg24375607 chr4:120327624 NA 0.75 10.76 0.51 2.15e-23 Corneal astigmatism; LUSC cis rs4842666 0.915 rs6538195 chr12:90062376 G/A cg00757033 chr12:89920650 WDR51B 0.5 7.15 0.36 5.35e-12 Blood pressure; LUSC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg16405210 chr4:1374714 KIAA1530 -0.48 -7.05 -0.36 1.01e-11 Obesity-related traits; LUSC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg05110241 chr16:68378359 PRMT7 -0.46 -5.85 -0.3 1.2e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs724744 0.679 rs1205929 chr6:22359126 T/C cg13807341 chr11:118445984 ARCN1 -0.36 -6.09 -0.32 3.12e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg04827223 chr11:72435913 ARAP1 -0.88 -15.22 -0.64 4.31e-40 Body mass index; LUSC cis rs34779708 0.733 rs4102764 chr10:35545392 T/C cg03585969 chr10:35415529 CREM 0.53 7.37 0.37 1.38e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9393777 0.920 rs67859638 chr6:27357978 A/G cg09904177 chr6:26538194 HMGN4 -0.77 -5.7 -0.3 2.63e-8 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs6908512 chr6:135367757 A/G cg24558204 chr6:135376177 HBS1L 0.57 8.77 0.43 9.11e-17 Red blood cell count; LUSC cis rs897984 0.762 rs2305880 chr16:30999462 T/C cg02466173 chr16:30829666 NA 0.56 11.11 0.52 1.3e-24 Dementia with Lewy bodies; LUSC cis rs7582720 1.000 rs114702158 chr2:203821793 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9527 0.590 rs1541213 chr10:104885330 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs17604090 1.000 rs73297441 chr7:29684363 T/C cg19413766 chr7:29689036 LOC646762 -0.58 -6.76 -0.35 6.1e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg18404041 chr3:52824283 ITIH1 -0.59 -11.16 -0.52 8.53e-25 Bipolar disorder; LUSC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg07061783 chr6:25882402 NA 0.36 5.84 0.3 1.25e-8 Blood metabolite levels; LUSC cis rs969413 0.624 rs9914093 chr17:79260653 C/G cg14413466 chr17:79170920 AZI1 -0.33 -6.34 -0.33 7.48e-10 Frontotemporal dementia; LUSC cis rs2204008 0.713 rs11173567 chr12:38089375 T/C cg13010199 chr12:38710504 ALG10B 0.62 9.06 0.44 1.14e-17 Bladder cancer; LUSC cis rs68170813 0.559 rs2023892 chr7:106847686 C/T cg02696742 chr7:106810147 HBP1 0.63 9.46 0.46 5.51e-19 Coronary artery disease; LUSC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg12463550 chr7:65579703 CRCP 0.5 7.0 0.36 1.4e-11 Aortic root size; LUSC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg05855489 chr10:104503620 C10orf26 0.58 9.32 0.45 1.66e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1451375 0.652 rs7779110 chr7:50625651 T/C cg18232548 chr7:50535776 DDC 0.48 6.61 0.34 1.54e-10 Malaria; LUSC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.73 -12.53 -0.57 8.75e-30 Total body bone mineral density; LUSC cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.1 -0.36 7.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg01652190 chr22:50026171 C22orf34 -0.31 -6.39 -0.33 5.51e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7927592 0.956 rs7102273 chr11:68385579 T/C cg01657329 chr11:68192670 LRP5 -0.44 -6.62 -0.34 1.41e-10 Total body bone mineral density; LUSC cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs79349575 0.783 rs59270107 chr17:47026185 A/T cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15533222 chr18:19285008 ABHD3 -0.44 -6.51 -0.34 2.76e-10 Electrocardiographic conduction measures; LUSC cis rs926938 0.527 rs360665 chr1:115478503 A/T cg12756093 chr1:115239321 AMPD1 0.46 6.95 0.36 1.89e-11 Autism; LUSC cis rs11711311 0.736 rs13320940 chr3:113400954 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -5.72 -0.3 2.32e-8 IgG glycosylation; LUSC cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.79 -0.39 8.62e-14 Chronic sinus infection; LUSC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg12560992 chr17:57184187 TRIM37 0.88 16.86 0.68 1.36e-46 Intelligence (multi-trait analysis); LUSC cis rs2109514 0.840 rs13223362 chr7:116137006 G/A cg12739419 chr7:116140593 CAV2 -0.27 -5.91 -0.31 8.39e-9 Prevalent atrial fibrillation; LUSC cis rs9309473 0.948 rs10199224 chr2:73761446 C/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.51 -0.34 2.83e-10 Metabolite levels; LUSC cis rs9653442 0.510 rs12712068 chr2:100764439 A/G cg07810366 chr2:100720526 AFF3 -0.45 -7.76 -0.39 1.05e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs12681287 0.640 rs34794500 chr8:87449995 G/A cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs1997103 1.000 rs1997102 chr7:55399322 A/C cg17469321 chr7:55412551 NA -0.65 -10.44 -0.5 2.94e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg05855489 chr10:104503620 C10orf26 0.61 8.01 0.4 1.97e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg23649088 chr2:200775458 C2orf69 0.53 7.23 0.37 3.26e-12 Schizophrenia; LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg20295408 chr7:1910781 MAD1L1 -0.47 -6.7 -0.34 8.97e-11 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4683142 0.518 rs4682801 chr3:46021218 G/T cg08033130 chr3:45983597 CXCR6;FYCO1 0.39 6.16 0.32 2.13e-9 Methadone dose in opioid dependence; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.4e-14 Prudent dietary pattern; LUSC cis rs950169 0.922 rs11631096 chr15:85100929 G/C cg11189052 chr15:85197271 WDR73 0.48 5.89 0.31 9.66e-9 Schizophrenia; LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg14433983 chr11:636460 DRD4 -0.35 -5.85 -0.31 1.15e-8 Systemic lupus erythematosus; LUSC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg03060546 chr3:49711283 APEH 0.7 11.64 0.54 1.67e-26 Resting heart rate; LUSC cis rs782590 0.694 rs2627775 chr2:55877113 C/T cg18811423 chr2:55921094 PNPT1 0.8 13.51 0.59 1.77e-33 Metabolic syndrome; LUSC cis rs427941 0.632 rs201505 chr7:101760287 T/C cg06246474 chr7:101738831 CUX1 0.39 6.34 0.33 7.51e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC trans rs7395662 0.591 rs4882093 chr11:48530820 G/A cg03929089 chr4:120376271 NA -0.44 -6.01 -0.31 4.89e-9 HDL cholesterol; LUSC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg25427524 chr10:38739819 LOC399744 0.63 11.22 0.52 5.2e-25 Extrinsic epigenetic age acceleration; LUSC cis rs861020 0.677 rs2049998 chr1:210031154 C/T cg05527609 chr1:210001259 C1orf107 -1.0 -13.51 -0.59 1.68e-33 Orofacial clefts; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg14004847 chr7:1930337 MAD1L1 -0.54 -8.17 -0.41 6.43e-15 Bipolar disorder and schizophrenia; LUSC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg04865166 chr7:105162814 PUS7 0.51 5.74 0.3 2.17e-8 Bipolar disorder (body mass index interaction); LUSC trans rs955423 1.000 rs1696952 chr5:165725049 G/T cg05036173 chr2:108994528 SULT1C4 -0.27 -5.95 -0.31 6.67e-9 Body mass index; LUSC cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg26446133 chr18:72167187 CNDP2 -0.79 -9.76 -0.47 6.02e-20 Refractive error; LUSC cis rs765787 0.556 rs12915965 chr15:45512647 T/C cg25801113 chr15:45476975 SHF -0.32 -6.43 -0.33 4.34e-10 Uric acid levels; LUSC cis rs11098499 0.954 rs3890049 chr4:120326283 T/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg15017067 chr4:17643749 FAM184B -0.35 -5.65 -0.3 3.51e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -7.91 -0.4 3.9e-14 Bipolar disorder and schizophrenia; LUSC cis rs7202877 0.656 rs3851736 chr16:75387332 T/C cg04384234 chr16:75411784 CFDP1 -0.63 -8.86 -0.44 4.77e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6987853 0.736 rs2923446 chr8:42404177 G/A cg09913449 chr8:42400586 C8orf40 0.53 9.22 0.45 3.45e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg17330251 chr7:94953956 PON1 0.37 5.93 0.31 7.67e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg15704280 chr7:45808275 SEPT13 0.76 8.65 0.43 2.25e-16 Axial length; LUSC cis rs7107174 1.000 rs7941617 chr11:78021146 C/T cg02023728 chr11:77925099 USP35 0.48 7.13 0.36 6.23e-12 Testicular germ cell tumor; LUSC cis rs1448094 0.967 rs7301496 chr12:86321212 A/C cg18827107 chr12:86230957 RASSF9 -0.41 -5.98 -0.31 5.78e-9 Major depressive disorder; LUSC cis rs1808579 0.935 rs7239575 chr18:21120035 C/T cg14672496 chr18:21087552 C18orf8 -0.34 -5.94 -0.31 6.99e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs9811920 0.683 rs793439 chr3:99637783 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.38 5.66 0.3 3.21e-8 Axial length; LUSC cis rs929354 1.000 rs1182378 chr7:157048322 T/C cg17757837 chr7:157058334 UBE3C -0.9 -14.74 -0.63 3.25e-38 Body mass index; LUSC cis rs4474465 1.000 rs10899533 chr11:78208480 T/C cg27205649 chr11:78285834 NARS2 0.51 6.0 0.31 5.16e-9 Alzheimer's disease (survival time); LUSC cis rs7615952 0.736 rs11921945 chr3:125643719 A/G cg05084668 chr3:125655381 ALG1L -0.76 -11.83 -0.54 3.33e-27 Blood pressure (smoking interaction); LUSC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg20573242 chr4:122745356 CCNA2 0.43 6.67 0.34 1.07e-10 Type 2 diabetes; LUSC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.33 -0.41 2.1e-15 Lymphocyte counts; LUSC cis rs1577917 0.958 rs1414199 chr6:86522370 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.83 -0.43 6.08e-17 Response to antipsychotic treatment; LUSC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg27432699 chr2:27873401 GPN1 -0.58 -8.68 -0.43 1.72e-16 Total body bone mineral density; LUSC trans rs62238980 0.614 rs117195584 chr22:32390013 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs12439619 0.921 rs4778672 chr15:82537354 G/T cg04831495 chr15:85060580 GOLGA6L5 0.57 8.71 0.43 1.38e-16 Intelligence (multi-trait analysis); LUSC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg13607699 chr17:42295918 UBTF 0.48 7.51 0.38 5.58e-13 Total body bone mineral density; LUSC cis rs6840360 0.533 rs13119490 chr4:152713412 A/G cg22705602 chr4:152727874 NA 0.38 7.92 0.4 3.61e-14 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.43 0.56 1.96e-29 Motion sickness; LUSC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.84 -13.58 -0.6 9.75e-34 Menarche (age at onset); LUSC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg14829155 chr15:31115871 NA 0.46 6.57 0.34 1.89e-10 Huntington's disease progression; LUSC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.54 0.46 3.2e-19 Bipolar disorder; LUSC cis rs875971 0.660 rs10229345 chr7:65982168 G/C cg00343986 chr7:65444356 GUSB 0.39 5.74 0.3 2.14e-8 Aortic root size; LUSC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03264133 chr6:25882463 NA -0.73 -11.79 -0.54 4.8e-27 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.643 rs7479473 chr11:929111 C/T ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg06422659 chr12:57481370 NAB2 0.37 6.13 0.32 2.44e-9 Schizophrenia; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg04450456 chr4:17643702 FAM184B 0.34 5.71 0.3 2.48e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.71 0.3 2.49e-8 Life satisfaction; LUSC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg22535103 chr8:58192502 C8orf71 -0.67 -7.25 -0.37 2.97e-12 Developmental language disorder (linguistic errors); LUSC cis rs295140 0.507 rs1369842 chr2:201108987 C/A cg23649088 chr2:200775458 C2orf69 -0.42 -6.3 -0.33 9.47e-10 QT interval; LUSC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.72 -0.35 7.71e-11 Aortic root size; LUSC cis rs4631830 0.900 rs10763588 chr10:51539762 G/T cg16070123 chr10:51489643 NA -0.51 -8.09 -0.4 1.12e-14 Prostate-specific antigen levels; LUSC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.39 0.56 2.97e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg15073853 chr19:18549131 ISYNA1 -0.32 -5.84 -0.3 1.24e-8 Breast cancer; LUSC cis rs66887589 0.837 rs6534135 chr4:120406302 A/G cg24375607 chr4:120327624 NA 0.5 7.77 0.39 9.66e-14 Diastolic blood pressure; LUSC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg16928487 chr17:17741425 SREBF1 -0.42 -8.29 -0.41 2.74e-15 Total body bone mineral density; LUSC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg00149659 chr3:10157352 C3orf10 0.6 8.3 0.41 2.62e-15 Alzheimer's disease; LUSC cis rs1775715 0.705 rs2778651 chr10:32106575 C/T cg04359828 chr10:32216031 ARHGAP12 0.41 6.95 0.36 1.95e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4654899 0.802 rs3767247 chr1:21227338 T/C cg02927042 chr1:21476669 EIF4G3 -0.36 -5.67 -0.3 3.01e-8 Superior frontal gyrus grey matter volume; LUSC cis rs10489202 0.583 rs203782 chr1:167882386 A/G cg24449463 chr1:168025552 DCAF6 0.73 11.8 0.54 4.2e-27 Schizophrenia; LUSC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg06713675 chr4:122721982 EXOSC9 0.45 8.02 0.4 1.85e-14 Type 2 diabetes; LUSC cis rs7075426 1.000 rs7075426 chr10:88216402 G/A cg07322936 chr10:88137208 NA -0.49 -7.31 -0.37 1.98e-12 Migraine without aura; LUSC cis rs7428496 0.528 rs13065800 chr3:142251714 G/A cg16271453 chr3:142027066 XRN1 -0.51 -8.77 -0.43 9.61e-17 Mean corpuscular hemoglobin; LUSC cis rs7923609 0.783 rs7100409 chr10:65330195 T/A cg01631684 chr10:65280961 REEP3 0.4 5.97 0.31 6.15e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7131987 0.683 rs7954278 chr12:29459290 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.68 -0.34 9.99e-11 QT interval; LUSC cis rs2273669 0.504 rs117426315 chr6:109450464 G/A cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg22862634 chr11:62369728 EML3;MTA2 -0.59 -9.67 -0.47 1.18e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg27588902 chr6:42928151 GNMT -0.3 -6.47 -0.33 3.55e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7829975 0.591 rs12677543 chr8:8644274 G/C cg18904891 chr8:8559673 CLDN23 0.43 6.56 0.34 2.04e-10 Mood instability; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22266470 chr19:51014659 JOSD2 -0.41 -6.04 -0.31 4.11e-9 Electrocardiographic conduction measures; LUSC cis rs644799 0.544 rs56298021 chr11:95545113 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.23 0.45 3.17e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7659604 1.000 rs73844281 chr4:122664688 A/G cg19748678 chr4:122722346 EXOSC9 0.48 7.47 0.38 7.05e-13 Type 2 diabetes; LUSC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.94 0.48 1.47e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4237845 0.586 rs4760174 chr12:58320436 G/A cg00677455 chr12:58241039 CTDSP2 0.44 6.3 0.33 9.57e-10 Intelligence (multi-trait analysis); LUSC cis rs4930103 0.602 rs170101 chr11:2008936 C/T cg23202291 chr11:1979235 NA 0.43 6.53 0.34 2.4e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7789940 1.000 rs758944 chr7:75953297 G/T cg15798862 chr7:76129360 DTX2 -0.51 -8.59 -0.43 3.4e-16 Multiple sclerosis; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg16182055 chr5:137879011 ETF1 0.64 6.13 0.32 2.47e-9 Body mass index; LUSC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg17554472 chr22:41940697 POLR3H -0.47 -5.79 -0.3 1.6e-8 Vitiligo; LUSC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg06112835 chr11:68658793 MRPL21 0.51 7.82 0.39 7.01e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2797160 0.967 rs2226158 chr6:125995467 C/T cg05901451 chr6:126070800 HEY2 -0.61 -9.1 -0.45 8.25e-18 Endometrial cancer; LUSC cis rs6845621 0.901 rs7697728 chr4:18922514 C/T cg12196642 chr4:18937545 NA -0.34 -6.37 -0.33 6.1e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2404602 0.679 rs12908421 chr15:76881794 T/G cg26408565 chr15:76604113 ETFA -0.48 -7.74 -0.39 1.18e-13 Blood metabolite levels; LUSC cis rs12681288 0.578 rs10503154 chr8:969343 C/G cg04851639 chr8:1020857 NA -0.4 -8.09 -0.4 1.1e-14 Schizophrenia; LUSC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg26408565 chr15:76604113 ETFA -0.5 -7.98 -0.4 2.42e-14 Blood metabolite levels; LUSC cis rs72781680 1.000 rs12623496 chr2:24181583 C/T cg08917208 chr2:24149416 ATAD2B 0.91 10.18 0.49 2.2e-21 Lymphocyte counts; LUSC cis rs10504073 0.669 rs62507251 chr8:50028524 T/G cg00325661 chr8:49890786 NA 0.61 9.5 0.46 4.19e-19 Blood metabolite ratios; LUSC cis rs3818285 0.556 rs3758409 chr10:111669239 A/C cg00817464 chr10:111662876 XPNPEP1 -0.69 -9.78 -0.47 5.13e-20 Superior crus of antihelix expression; LUSC cis rs10927875 0.864 rs12135073 chr1:16167799 C/T cg21385522 chr1:16154831 NA 0.94 15.8 0.65 2.17e-42 Dilated cardiomyopathy; LUSC cis rs11229555 0.874 rs11229512 chr11:58286105 T/C cg15696309 chr11:58395628 NA -0.71 -9.0 -0.44 1.77e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.25 0.32 1.28e-9 Bipolar disorder; LUSC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg12311346 chr5:56204834 C5orf35 -0.63 -8.9 -0.44 3.65e-17 Coronary artery disease; LUSC cis rs9326248 0.520 rs10892060 chr11:116881662 C/A cg01368799 chr11:117014884 PAFAH1B2 0.59 9.19 0.45 4.23e-18 Blood protein levels; LUSC cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg25174290 chr11:3078921 CARS 0.59 9.57 0.46 2.39e-19 Longevity; LUSC cis rs7615952 0.688 rs12638224 chr3:125541320 C/T cg05084668 chr3:125655381 ALG1L -0.59 -8.29 -0.41 2.76e-15 Blood pressure (smoking interaction); LUSC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg20887711 chr4:1340912 KIAA1530 0.51 7.91 0.4 3.8e-14 Obesity-related traits; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 11.43 0.53 9.66e-26 Alzheimer's disease; LUSC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg04511125 chr2:88470314 THNSL2 -0.44 -6.61 -0.34 1.52e-10 Response to metformin (IC50); LUSC cis rs7568458 0.846 rs6738645 chr2:85783128 T/G cg02493740 chr2:85810744 VAMP5 -0.37 -6.64 -0.34 1.24e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12058391 chr8:63951472 GGH -0.44 -6.36 -0.33 6.5e-10 Electrocardiographic conduction measures; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg05025164 chr4:1340916 KIAA1530 0.46 7.07 0.36 9.08e-12 Obesity-related traits; LUSC cis rs7089973 0.604 rs7919649 chr10:116609576 T/C cg25233709 chr10:116636983 FAM160B1 0.37 6.51 0.34 2.82e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg03676636 chr4:99064102 C4orf37 0.37 8.23 0.41 4.36e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg06784218 chr1:46089804 CCDC17 -0.5 -10.06 -0.48 5.91e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.34 0.37 1.65e-12 Bipolar disorder; LUSC cis rs6964587 1.000 rs7811873 chr7:91751120 G/A cg17063962 chr7:91808500 NA 0.6 9.45 0.46 6.13e-19 Breast cancer; LUSC cis rs7746199 0.736 rs13209332 chr6:27520752 T/A cg26958806 chr6:27640298 NA 0.77 6.55 0.34 2.23e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4595586 0.545 rs12828001 chr12:39392208 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs9905704 0.918 rs302868 chr17:56752123 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.7 0.39 1.58e-13 Testicular germ cell tumor; LUSC trans rs6480314 0.542 rs7079054 chr10:70026161 G/A cg04882175 chr6:131122610 NA -0.55 -6.34 -0.33 7.25e-10 Optic nerve measurement (disc area); LUSC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg05340658 chr4:99064831 C4orf37 0.68 11.63 0.54 1.78e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.59 0.43 3.5e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8060686 0.641 rs8058690 chr16:68136622 T/G cg27539214 chr16:67997921 SLC12A4 -0.55 -7.56 -0.38 3.86e-13 HDL cholesterol;Metabolic syndrome; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16041611 chr6:43139680 SRF 0.46 7.52 0.38 5.07e-13 Triglycerides; LUSC cis rs2730245 0.527 rs842702 chr7:158696814 C/T cg24397884 chr7:158709396 WDR60 0.8 9.04 0.44 1.31e-17 Height; LUSC trans rs853679 0.517 rs67878650 chr6:28142587 G/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.16e-9 Depression; LUSC cis rs2970818 0.831 rs9971728 chr12:4601068 G/A cg11146114 chr12:4671731 NA -0.6 -5.97 -0.31 6.03e-9 Phosphorus levels; LUSC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg18876405 chr7:65276391 NA -0.55 -8.7 -0.43 1.5e-16 Aortic root size; LUSC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg02807482 chr3:125708958 NA -0.54 -6.63 -0.34 1.38e-10 Blood pressure (smoking interaction); LUSC cis rs2067615 0.599 rs1579808 chr12:107239947 A/G cg15890332 chr12:107067104 RFX4 -0.33 -6.06 -0.31 3.72e-9 Heart rate; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg22166914 chr1:53195759 ZYG11B 0.5 8.25 0.41 3.62e-15 Monocyte count; LUSC cis rs9457247 0.508 rs6941355 chr6:167506238 A/G cg07741184 chr6:167504864 NA 0.4 7.01 0.36 1.34e-11 Crohn's disease; LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg10729496 chr3:10149963 C3orf24 0.49 6.45 0.33 3.96e-10 Alzheimer's disease; LUSC cis rs9816226 0.938 rs55742087 chr3:185830488 C/T cg00760338 chr3:185826511 ETV5 -0.69 -8.85 -0.44 5.13e-17 Obesity;Body mass index; LUSC trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg03929089 chr4:120376271 NA -0.91 -14.99 -0.63 3.48e-39 Height; LUSC cis rs9879311 0.966 rs6442165 chr3:10415108 A/C cg11030744 chr3:10328490 GHRL;GHRLOS 0.48 7.88 0.4 4.82e-14 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs12956009 0.518 rs10163861 chr18:44820214 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.76 0.35 6.34e-11 Educational attainment (years of education); LUSC cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg19789473 chr17:27170043 C17orf63 -0.3 -5.65 -0.3 3.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9815354 0.812 rs17215988 chr3:41851320 A/C cg03022575 chr3:42003672 ULK4 0.85 8.56 0.42 4.04e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs950169 0.922 rs11631096 chr15:85100929 G/C cg12863693 chr15:85201151 NMB 0.37 7.3 0.37 2.17e-12 Schizophrenia; LUSC cis rs6942756 0.806 rs6467237 chr7:128964831 A/G cg02491457 chr7:128862824 NA -0.48 -7.17 -0.37 4.95e-12 White matter hyperintensity burden; LUSC cis rs654950 0.774 rs941972 chr1:42040740 T/C cg06885757 chr1:42089581 HIVEP3 -0.42 -8.52 -0.42 5.71e-16 Airway imaging phenotypes; LUSC cis rs9527 0.590 rs7073323 chr10:104797423 A/C cg08330031 chr10:104623503 C10orf32 0.34 5.79 0.3 1.64e-8 Arsenic metabolism; LUSC cis rs77633900 0.614 rs2439989 chr15:76883862 G/C cg21673338 chr15:77095150 SCAPER -0.72 -6.99 -0.36 1.48e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs7911264 0.739 rs10786050 chr10:94367230 A/G cg25093409 chr10:94429542 NA 0.36 6.21 0.32 1.59e-9 Inflammatory bowel disease; LUSC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.62 5.82 0.3 1.4e-8 Cerebrospinal P-tau181p levels; LUSC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg04733989 chr22:42467013 NAGA 0.55 8.7 0.43 1.54e-16 Schizophrenia; LUSC cis rs11098499 0.657 rs71614442 chr4:120379346 C/T cg09307838 chr4:120376055 NA 0.77 11.2 0.52 6.24e-25 Corneal astigmatism; LUSC trans rs6089829 0.926 rs1060491 chr20:61665817 C/A cg13615516 chr5:77269221 NA -0.4 -6.65 -0.34 1.18e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6669072 0.869 rs7526803 chr1:91235725 A/G cg08895590 chr1:91227319 NA 0.35 7.55 0.38 4.26e-13 Cognitive function; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg13395646 chr4:1353034 KIAA1530 -0.63 -10.47 -0.5 2.21e-22 Longevity; LUSC cis rs7107174 1.000 rs2512535 chr11:77971468 C/T cg02023728 chr11:77925099 USP35 0.47 7.12 0.36 6.7e-12 Testicular germ cell tumor; LUSC cis rs317865 0.737 rs73234648 chr4:16193602 T/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.61 5.88 0.31 1e-8 Kidney disease (early stage) in type 1 diabetes; LUSC cis rs9649213 0.614 rs3944111 chr7:98005766 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.73 -10.19 -0.49 2.06e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs644799 0.625 rs1255177 chr11:95471495 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.31 0.33 8.94e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs611744 0.647 rs10106246 chr8:109268710 T/C cg21045802 chr8:109455806 TTC35 0.43 6.7 0.34 9e-11 Dupuytren's disease; LUSC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg09699651 chr6:150184138 LRP11 0.41 6.48 0.33 3.3e-10 Testicular germ cell tumor; LUSC cis rs1547553 1 rs1547553 chr18:77926197 C/A cg14906638 chr18:78001859 PARD6G -0.65 -7.41 -0.38 1.06e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs34172651 0.917 rs11642302 chr16:24770856 G/A cg00339695 chr16:24857497 SLC5A11 0.37 6.59 0.34 1.69e-10 Intelligence (multi-trait analysis); LUSC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg21138405 chr5:131827807 IRF1 0.34 6.04 0.31 4.22e-9 Breast cancer;Mosquito bite size; LUSC cis rs6543140 0.964 rs6736135 chr2:103064924 A/G cg09003973 chr2:102972529 NA 0.54 6.98 0.36 1.58e-11 Blood protein levels; LUSC cis rs2070433 1.000 rs2070433 chr21:47961386 G/A cg12379764 chr21:47803548 PCNT 0.8 10.4 0.49 4.02e-22 Lymphocyte counts; LUSC cis rs477692 1.000 rs569235 chr10:131411620 T/C cg05714579 chr10:131428358 MGMT 0.52 7.64 0.39 2.34e-13 Response to temozolomide; LUSC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg21573476 chr21:45109991 RRP1B -0.37 -6.01 -0.31 4.75e-9 Mean corpuscular volume; LUSC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg10523679 chr1:76189770 ACADM 0.91 14.45 0.62 4.09e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg11062466 chr8:58055876 NA 0.5 6.42 0.33 4.55e-10 Developmental language disorder (linguistic errors); LUSC cis rs1949733 0.598 rs4696838 chr4:8540349 A/G cg13073564 chr4:8508604 NA 0.35 6.34 0.33 7.5e-10 Response to antineoplastic agents; LUSC cis rs9354308 0.933 rs2802062 chr6:66561973 C/G cg07460842 chr6:66804631 NA 0.49 5.94 0.31 7.24e-9 Metabolite levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08209163 chr13:28024472 MTIF3 -0.48 -6.4 -0.33 5.36e-10 Bipolar disorder and schizophrenia; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg11843238 chr5:131593191 PDLIM4 0.41 6.85 0.35 3.64e-11 Breast cancer; LUSC trans rs7944735 0.938 rs59185955 chr11:47961566 G/C cg03929089 chr4:120376271 NA 0.6 6.27 0.32 1.13e-9 Intraocular pressure; LUSC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg18302933 chr2:88491318 NA -0.38 -7.52 -0.38 5.01e-13 Response to metformin (IC50); LUSC cis rs10791323 0.576 rs4937840 chr11:133734322 C/G cg15485101 chr11:133734466 NA 0.41 7.52 0.38 5.16e-13 Childhood ear infection; LUSC cis rs3770081 1.000 rs78650586 chr2:86190783 G/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.97 -6.28 -0.32 1.06e-9 Facial emotion recognition (sad faces); LUSC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs57590327 0.503 rs7631052 chr3:81866235 C/A cg07356753 chr3:81810745 GBE1 -0.64 -9.97 -0.48 1.15e-20 Extraversion; LUSC cis rs3960554 0.808 rs13438599 chr7:75768022 G/A cg17325771 chr7:75508891 RHBDD2 -0.42 -5.83 -0.3 1.34e-8 Eotaxin levels; LUSC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg13206674 chr6:150067644 NUP43 0.62 9.97 0.48 1.16e-20 Lung cancer; LUSC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg24250549 chr1:154909240 PMVK 0.6 9.76 0.47 5.94e-20 Prostate cancer; LUSC cis rs9378688 1.000 rs72830182 chr6:2221488 C/T cg12303981 chr6:2244766 GMDS -0.55 -6.54 -0.34 2.37e-10 Caudate nucleus volume; LUSC cis rs4594175 0.886 rs11157802 chr14:51622984 C/T cg23942311 chr14:51606299 NA 0.31 5.98 0.31 5.79e-9 Cancer; LUSC cis rs1348850 0.574 rs11691740 chr2:178445161 A/G cg27490568 chr2:178487706 NA -0.38 -5.79 -0.3 1.66e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg12257692 chr3:49977190 RBM6 -0.22 -6.07 -0.32 3.38e-9 Intelligence (multi-trait analysis); LUSC cis rs12367572 1.000 rs7295923 chr12:45269284 C/T cg04608330 chr12:45269318 NELL2 -0.58 -9.3 -0.45 1.95e-18 Gut microbiome composition (summer); LUSC cis rs6982240 0.514 rs7002268 chr8:142277340 A/G cg27411547 chr8:142287226 NA -0.49 -8.35 -0.42 1.86e-15 Tonsillectomy; LUSC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg14552801 chr7:65878734 NA -0.44 -6.22 -0.32 1.51e-9 Aortic root size; LUSC cis rs7568458 0.684 rs67988001 chr2:85787123 C/T cg17127132 chr2:85788382 GGCX 0.43 6.2 0.32 1.71e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg04944784 chr2:26401820 FAM59B 0.67 8.96 0.44 2.41e-17 Gut microbiome composition (summer); LUSC cis rs7615952 0.558 rs17334039 chr3:125540308 A/G cg05084668 chr3:125655381 ALG1L -0.59 -8.33 -0.41 2.07e-15 Blood pressure (smoking interaction); LUSC cis rs11676348 0.772 rs7422358 chr2:218952778 C/T cg06547715 chr2:218990976 CXCR2 0.34 6.62 0.34 1.45e-10 Ulcerative colitis; LUSC cis rs6818397 1.000 rs6818397 chr4:3434885 A/C cg08741688 chr4:3415352 RGS12 0.37 6.26 0.32 1.19e-9 LDL cholesterol levels;Total cholesterol levels; LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg08088566 chr11:430123 ANO9 0.57 6.7 0.34 8.64e-11 Body mass index; LUSC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.48e-24 Aortic root size; LUSC cis rs7264396 0.580 rs2425181 chr20:34447709 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -6.83 -0.35 3.94e-11 Total cholesterol levels; LUSC cis rs10771431 0.782 rs10771415 chr12:9358223 C/T cg08997352 chr12:9597637 DDX12 -0.71 -11.41 -0.53 1.12e-25 Breast size; LUSC trans rs9467711 0.790 rs34107459 chr6:26328353 T/C cg06606381 chr12:133084897 FBRSL1 -0.75 -6.63 -0.34 1.34e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg23982607 chr1:1823379 GNB1 -0.73 -14.91 -0.63 6.6e-39 Body mass index; LUSC cis rs4700695 0.719 rs40176 chr5:65464965 C/T cg21114390 chr5:65439923 SFRS12 -0.65 -9.28 -0.45 2.12e-18 Facial morphology (factor 19); LUSC trans rs7615952 0.576 rs12497295 chr3:125818650 G/A cg07211511 chr3:129823064 LOC729375 -0.75 -9.67 -0.47 1.2e-19 Blood pressure (smoking interaction); LUSC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg15704280 chr7:45808275 SEPT13 -0.56 -6.96 -0.36 1.85e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs7707921 0.767 rs862241 chr5:81588011 G/A cg15871215 chr5:81402204 ATG10 0.45 7.1 0.36 7.45e-12 Breast cancer; LUSC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg15848620 chr12:58087721 OS9 0.45 5.74 0.3 2.18e-8 Multiple sclerosis; LUSC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg23711669 chr6:146136114 FBXO30 0.9 16.67 0.67 8.1e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 9.05 0.44 1.24e-17 Menopause (age at onset); LUSC cis rs6582630 0.638 rs61931383 chr12:38513845 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.3 -0.41 2.58e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg07701084 chr6:150067640 NUP43 0.58 9.03 0.44 1.41e-17 Lung cancer; LUSC cis rs738321 0.756 rs11570745 chr22:38513493 C/T cg25457927 chr22:38595422 NA -0.32 -6.11 -0.32 2.8e-9 Breast cancer; LUSC cis rs3126085 0.935 rs4845736 chr1:152175551 G/A cg26876637 chr1:152193138 HRNR 0.46 6.62 0.34 1.46e-10 Atopic dermatitis; LUSC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg12463550 chr7:65579703 CRCP 0.52 7.58 0.38 3.39e-13 Aortic root size; LUSC cis rs8180040 1.000 rs295428 chr3:47359262 G/T cg02527881 chr3:46936655 PTH1R -0.42 -7.49 -0.38 6.18e-13 Colorectal cancer; LUSC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg06636001 chr8:8085503 FLJ10661 -0.63 -10.32 -0.49 7.4e-22 Mood instability; LUSC cis rs7582180 0.903 rs6755791 chr2:100895872 G/A cg08017756 chr2:100939284 LONRF2 -0.36 -6.01 -0.31 4.77e-9 Intelligence (multi-trait analysis); LUSC trans rs9871760 1.000 rs9871760 chr3:126993099 C/A cg17872838 chr13:52607339 UTP14C 0.35 6.23 0.32 1.44e-9 Whole-brain volume; LUSC trans rs11992162 0.967 rs4840601 chr8:11828730 G/C cg08975724 chr8:8085496 FLJ10661 0.49 6.95 0.36 1.98e-11 Monocyte count; LUSC cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg21535247 chr6:8435926 SLC35B3 -0.58 -8.8 -0.43 7.23e-17 Motion sickness; LUSC cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg03146154 chr1:46216737 IPP 0.52 7.99 0.4 2.28e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1728785 0.818 rs1728769 chr16:68564186 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg17366294 chr4:99064904 C4orf37 0.54 9.48 0.46 4.75e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs6541297 0.887 rs4846906 chr1:230284257 C/A cg20703242 chr1:230279135 GALNT2 0.62 8.74 0.43 1.12e-16 Coronary artery disease; LUSC trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.29 -0.37 2.28e-12 Neuroticism; LUSC cis rs12286929 0.669 rs11606837 chr11:115042837 C/T cg04055981 chr11:115044050 NA 0.43 7.69 0.39 1.68e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8072100 0.905 rs11651766 chr17:45574931 G/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.37 -6.12 -0.32 2.57e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg05025164 chr4:1340916 KIAA1530 0.52 8.34 0.41 2.03e-15 Longevity; LUSC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg19346786 chr7:2764209 NA -0.43 -7.31 -0.37 2.05e-12 Height; LUSC cis rs6964587 0.967 rs7786031 chr7:91649001 T/G cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.71e-18 Breast cancer; LUSC cis rs250677 0.617 rs166106 chr5:148447061 T/C cg12140854 chr5:148520817 ABLIM3 -0.4 -6.05 -0.31 3.95e-9 Breast cancer; LUSC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg18099408 chr3:52552593 STAB1 -0.43 -7.56 -0.38 3.9e-13 Bipolar disorder; LUSC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg05368731 chr17:41323189 NBR1 -0.83 -13.79 -0.6 1.46e-34 Menopause (age at onset); LUSC cis rs9837602 0.938 rs9873709 chr3:99711687 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.93 -0.31 7.43e-9 Breast cancer; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg11235426 chr6:292522 DUSP22 -0.65 -10.53 -0.5 1.36e-22 Menopause (age at onset); LUSC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC cis rs9341808 0.718 rs2322631 chr6:80843956 A/C cg08355045 chr6:80787529 NA 0.57 10.03 0.48 6.94e-21 Sitting height ratio; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02037503 chr14:23540729 ACIN1 0.59 8.21 0.41 4.89e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7607369 0.680 rs533760 chr2:219381405 T/C cg02176678 chr2:219576539 TTLL4 0.74 14.41 0.62 6.18e-37 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.07 -0.32 3.41e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9527 0.545 rs7894588 chr10:104756030 A/T cg23093090 chr10:104574429 C10orf26 -0.34 -6.03 -0.31 4.33e-9 Arsenic metabolism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03153608 chr11:64126457 RPS6KA4 -0.43 -6.3 -0.33 9.57e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg26441486 chr22:50317300 CRELD2 0.48 7.21 0.37 3.88e-12 Schizophrenia; LUSC cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs6062509 0.965 rs6062506 chr20:62352389 T/G cg21849932 chr20:62369462 LIME1 -0.4 -5.93 -0.31 7.59e-9 Prostate cancer; LUSC cis rs9581857 0.547 rs9581877 chr13:28104321 T/A cg22138327 chr13:27999177 GTF3A 0.66 7.03 0.36 1.18e-11 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg11752832 chr7:134001865 SLC35B4 0.54 8.31 0.41 2.37e-15 Mean platelet volume; LUSC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg14019146 chr3:50243930 SLC38A3 -0.33 -7.16 -0.36 5.01e-12 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg01879757 chr17:41196368 BRCA1 -0.51 -8.03 -0.4 1.66e-14 Menopause (age at onset); LUSC cis rs9815354 1.000 rs1717027 chr3:41987920 T/C cg03022575 chr3:42003672 ULK4 -0.51 -5.74 -0.3 2.11e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs17661538 0.614 rs34849615 chr10:18414460 A/T cg03634479 chr10:18430412 CACNB2 0.63 6.88 0.35 2.9e-11 Response to antipsychotic treatment; LUSC cis rs7760535 0.826 rs7753887 chr6:111855107 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.39 -7.25 -0.37 2.95e-12 Metabolic traits; LUSC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg16414030 chr3:133502952 NA -0.57 -9.25 -0.45 2.77e-18 Iron status biomarkers; LUSC cis rs7903847 0.656 rs12412478 chr10:99134923 C/T cg20016023 chr10:99160130 RRP12 -0.3 -6.5 -0.34 2.95e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs6688613 0.685 rs742048 chr1:166910145 A/C cg07049167 chr1:166818506 POGK -0.41 -6.1 -0.32 3.01e-9 Refractive astigmatism; LUSC cis rs7089973 0.966 rs12775180 chr10:116639754 T/C cg23260525 chr10:116636907 FAM160B1 0.38 7.37 0.37 1.39e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs5769707 0.521 rs7285764 chr22:50058561 T/C cg20744362 chr22:50050164 C22orf34 0.36 6.66 0.34 1.1e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg12432903 chr7:1882776 MAD1L1 -0.49 -8.45 -0.42 8.85e-16 Bipolar disorder and schizophrenia; LUSC trans rs1997103 1.000 rs10263552 chr7:55404747 C/T cg20935933 chr6:143382018 AIG1 0.5 7.27 0.37 2.61e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.15 -0.36 5.59e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg00745463 chr17:30367425 LRRC37B -0.83 -10.0 -0.48 8.87e-21 Hip circumference adjusted for BMI; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg01238044 chr22:24384105 GSTT1 0.55 8.14 0.41 7.96e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg03790207 chr6:42947109 PEX6 -0.46 -7.06 -0.36 9.53e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11030122 0.702 rs10835399 chr11:3989182 G/A cg18678763 chr11:4115507 RRM1 -0.45 -5.77 -0.3 1.82e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs16937 0.711 rs11240384 chr1:205172175 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg05535760 chr7:792225 HEATR2 0.91 9.61 0.47 1.88e-19 Cerebrospinal P-tau181p levels; LUSC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg13683864 chr3:40499215 RPL14 -1.13 -21.27 -0.76 4.37e-64 Renal cell carcinoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14935078 chr19:17414399 ABHD8 0.42 6.58 0.34 1.81e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg06064525 chr11:970664 AP2A2 -0.48 -10.38 -0.49 4.64e-22 Alzheimer's disease (late onset); LUSC cis rs1018836 0.892 rs13267237 chr8:91550820 T/C cg16814680 chr8:91681699 NA -0.71 -11.74 -0.54 6.95e-27 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.33 0.37 1.79e-12 Cognitive function; LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg17178900 chr1:205818956 PM20D1 0.44 6.13 0.32 2.48e-9 Prostate-specific antigen levels; LUSC cis rs4964805 0.865 rs11111796 chr12:104205928 C/T cg02344784 chr12:104178138 NT5DC3 0.41 6.6 0.34 1.64e-10 Attention deficit hyperactivity disorder; LUSC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg07952391 chr2:88470173 THNSL2 0.77 6.84 0.35 3.74e-11 Plasma clusterin levels; LUSC cis rs477692 0.905 rs570967 chr10:131421330 T/G cg11019008 chr10:131425282 MGMT 0.4 6.2 0.32 1.68e-9 Response to temozolomide; LUSC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg13206674 chr6:150067644 NUP43 0.6 9.54 0.46 3.08e-19 Lung cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25999486 chr13:76056030 TBC1D4 -0.39 -6.36 -0.33 6.5e-10 Electrocardiographic conduction measures; LUSC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg02475777 chr4:1388615 CRIPAK 0.43 6.44 0.33 4.04e-10 Obesity-related traits; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg10729496 chr3:10149963 C3orf24 0.61 7.88 0.4 4.77e-14 Alzheimer's disease; LUSC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg09796270 chr17:17721594 SREBF1 -0.45 -7.9 -0.4 4.09e-14 Total body bone mineral density; LUSC cis rs929354 0.772 rs2301914 chr7:157000176 T/C cg05182265 chr7:156933206 UBE3C -0.6 -9.68 -0.47 1.04e-19 Body mass index; LUSC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.05 -0.36 1.06e-11 Blood metabolite levels; LUSC cis rs1832871 0.521 rs62437409 chr6:158820221 G/C cg07165851 chr6:158734300 TULP4 0.4 6.34 0.33 7.55e-10 Height; LUSC cis rs7100689 0.646 rs7903701 chr10:82129268 T/C cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg22907277 chr7:1156413 C7orf50 0.44 6.77 0.35 5.64e-11 Longevity;Endometriosis; LUSC cis rs34779708 0.966 rs4934736 chr10:35496868 G/A cg04310649 chr10:35416472 CREM -0.4 -6.24 -0.32 1.33e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs865483 0.895 rs853234 chr17:35843050 A/G cg06716730 chr17:35851459 DUSP14 -0.26 -5.89 -0.31 9.24e-9 Monocyte count; LUSC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg00750074 chr16:89608354 SPG7 -0.56 -10.19 -0.49 2.07e-21 Multiple myeloma (IgH translocation); LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg22907277 chr7:1156413 C7orf50 0.67 7.26 0.37 2.66e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9468199 0.505 rs72847381 chr6:27873931 G/A cg08851530 chr6:28072375 NA 1.24 8.4 0.42 1.32e-15 Parkinson's disease; LUSC trans rs853679 0.607 rs13217619 chr6:28306671 T/C cg06606381 chr12:133084897 FBRSL1 -1.08 -9.45 -0.46 6.26e-19 Depression; LUSC cis rs79911532 0.515 rs10235228 chr7:75833282 G/A cg03592824 chr7:75666768 STYXL1 0.59 5.97 0.31 6e-9 Mononucleosis; LUSC cis rs9837602 0.938 rs9823908 chr3:99795507 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.03 -0.31 4.31e-9 Breast cancer; LUSC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg06454157 chr6:167490870 NA -0.24 -5.94 -0.31 7.24e-9 Crohn's disease; LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg00684032 chr4:1343700 KIAA1530 0.37 6.54 0.34 2.32e-10 Obesity-related traits; LUSC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg10802521 chr3:52805072 NEK4 -0.53 -8.54 -0.42 4.72e-16 Bipolar disorder; LUSC cis rs9815354 1.000 rs17063599 chr3:41861676 C/T cg03022575 chr3:42003672 ULK4 0.59 6.55 0.34 2.18e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg15744005 chr10:104629667 AS3MT 0.31 6.54 0.34 2.34e-10 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10927875 0.832 rs4661342 chr1:16160773 C/G cg21385522 chr1:16154831 NA -0.97 -16.38 -0.67 1.1e-44 Dilated cardiomyopathy; LUSC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg22535103 chr8:58192502 C8orf71 -0.58 -6.91 -0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC trans rs11700980 0.551 rs58732433 chr21:30109534 C/T cg14791747 chr16:20752902 THUMPD1 0.55 5.98 0.31 5.75e-9 QRS complex (12-leadsum); LUSC cis rs10208940 0.764 rs7583649 chr2:68830939 T/C cg12452813 chr2:68675892 NA 0.57 5.88 0.31 9.87e-9 Urate levels in lean individuals; LUSC cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs8077577 0.895 rs6502640 chr17:18122485 G/A cg16794390 chr17:18148240 FLII 0.42 5.89 0.31 9.54e-9 Obesity-related traits; LUSC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg23711669 chr6:146136114 FBXO30 0.87 15.63 0.65 1.03e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17421506 chr11:18656159 SPTY2D1 0.45 6.67 0.34 1.04e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg20291162 chr17:40259547 DHX58 0.55 7.53 0.38 4.79e-13 Fibrinogen levels; LUSC cis rs7267979 1.000 rs4815417 chr20:25379526 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -20.18 -0.74 8.81e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg12463550 chr7:65579703 CRCP -0.51 -7.46 -0.38 7.72e-13 Aortic root size; LUSC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg07636037 chr3:49044803 WDR6 -1.02 -15.74 -0.65 3.94e-42 Parkinson's disease; LUSC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg19046167 chr17:80928561 B3GNTL1 0.45 6.81 0.35 4.52e-11 Breast cancer; LUSC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg00750074 chr16:89608354 SPG7 -0.63 -12.22 -0.56 1.24e-28 Multiple myeloma (IgH translocation); LUSC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.8 0.47 4.41e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg10360139 chr7:1886902 MAD1L1 -0.44 -6.91 -0.35 2.42e-11 Bipolar disorder and schizophrenia; LUSC trans rs6951245 0.507 rs11763865 chr7:1194274 G/A cg13565492 chr6:43139072 SRF -0.47 -5.98 -0.31 5.72e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs950169 0.686 rs12906474 chr15:85109237 A/G cg11189052 chr15:85197271 WDR73 0.46 5.72 0.3 2.35e-8 Schizophrenia; LUSC cis rs4654899 1.000 rs6426660 chr1:21361640 A/G cg01072550 chr1:21505969 NA -0.56 -8.54 -0.42 4.74e-16 Superior frontal gyrus grey matter volume; LUSC cis rs6545883 0.655 rs11893880 chr2:61422019 C/T cg15711740 chr2:61764176 XPO1 -0.4 -6.33 -0.33 7.72e-10 Tuberculosis; LUSC cis rs9314614 0.899 rs2977802 chr8:6694845 C/G cg27319216 chr8:6693540 XKR5 0.35 6.3 0.33 9.41e-10 IgA nephropathy;White blood cell count (basophil); LUSC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.06 0.52 1.93e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg22862634 chr11:62369728 EML3;MTA2 -0.49 -7.19 -0.37 4.27e-12 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs1983170 1.000 rs483532 chr1:91980447 A/G cg21854759 chr1:92012499 NA -0.44 -5.75 -0.3 2.02e-8 Eosinophil percentage of white cells; LUSC cis rs250677 0.958 rs36068 chr5:148417512 C/T cg18129178 chr5:148520854 ABLIM3 -0.66 -10.32 -0.49 7.39e-22 Breast cancer; LUSC cis rs7561273 0.609 rs3795953 chr2:24345707 C/G cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs1448094 0.802 rs12369634 chr12:86406792 C/G cg02569458 chr12:86230093 RASSF9 0.39 6.27 0.32 1.1e-9 Major depressive disorder; LUSC cis rs2486288 0.656 rs11629807 chr15:45547037 T/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.01 -0.4 1.89e-14 Glomerular filtration rate; LUSC cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg11584989 chr19:19387371 SF4 0.58 7.02 0.36 1.22e-11 Bipolar disorder; LUSC cis rs6681460 0.932 rs523188 chr1:67174422 A/G cg02459107 chr1:67143332 SGIP1 0.49 9.12 0.45 7.4e-18 Presence of antiphospholipid antibodies; LUSC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg11764359 chr7:65958608 NA -0.68 -10.36 -0.49 5.28e-22 Aortic root size; LUSC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg06713675 chr4:122721982 EXOSC9 -0.68 -12.08 -0.55 4.12e-28 Type 2 diabetes; LUSC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -8.19 -0.41 5.67e-15 Prostate cancer; LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg11645453 chr3:52864694 ITIH4 0.35 8.11 0.41 9.43e-15 Bipolar disorder; LUSC trans rs8072100 0.840 rs11079774 chr17:45479706 C/G cg04995722 chr7:26192034 NFE2L3 -0.39 -6.37 -0.33 6.27e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg20243544 chr17:37824526 PNMT 0.41 6.38 0.33 6.03e-10 Self-reported allergy; LUSC cis rs7582180 0.625 rs12612755 chr2:100906061 T/C cg08017756 chr2:100939284 LONRF2 -0.4 -7.35 -0.37 1.51e-12 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.582 rs11783950 chr8:8597831 A/C cg18904891 chr8:8559673 CLDN23 -0.41 -5.88 -0.31 1.01e-8 Mood instability; LUSC cis rs722599 0.683 rs7160852 chr14:75239424 T/C cg06637938 chr14:75390232 RPS6KL1 0.39 5.69 0.3 2.85e-8 IgG glycosylation; LUSC cis rs9650315 0.516 rs79664732 chr8:57202790 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.6 6.86 0.35 3.39e-11 Height; LUSC cis rs7216064 1.000 rs8081517 chr17:65845697 A/T cg12091567 chr17:66097778 LOC651250 -0.73 -9.42 -0.46 7.94e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg11764359 chr7:65958608 NA 0.71 11.02 0.52 2.65e-24 Aortic root size; LUSC cis rs9928842 0.823 rs4888365 chr16:75282247 A/G cg09066997 chr16:75300724 BCAR1 0.5 6.37 0.33 6.14e-10 Alcoholic chronic pancreatitis; LUSC cis rs11645898 0.935 rs35370634 chr16:72184566 C/T cg14768367 chr16:72042858 DHODH -0.65 -7.11 -0.36 7.28e-12 Blood protein levels; LUSC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs1595825 0.838 rs80172713 chr2:198508044 T/C cg19156104 chr2:198669113 PLCL1 -0.46 -5.78 -0.3 1.69e-8 Ulcerative colitis; LUSC cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC cis rs2075371 0.611 rs35428392 chr7:134019645 G/A cg00033643 chr7:134001901 SLC35B4 0.43 6.33 0.33 7.96e-10 Mean platelet volume; LUSC trans rs7615952 0.641 rs6805074 chr3:125772274 T/A cg07211511 chr3:129823064 LOC729375 -0.74 -9.59 -0.46 2.12e-19 Blood pressure (smoking interaction); LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg14092988 chr3:52407081 DNAH1 0.32 6.01 0.31 4.95e-9 Bipolar disorder; LUSC trans rs12431204 0.932 rs2323637 chr13:38447640 T/A cg25252598 chr12:6641602 NA 0.38 6.27 0.32 1.12e-9 Schizophrenia; LUSC cis rs208520 0.954 rs12190073 chr6:66983740 T/C cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg05585544 chr11:47624801 NA -0.42 -7.27 -0.37 2.63e-12 Subjective well-being; LUSC cis rs7474896 0.559 rs10740949 chr10:37978435 A/G cg25427524 chr10:38739819 LOC399744 -0.49 -6.53 -0.34 2.4e-10 Obesity (extreme); LUSC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg09650180 chr20:62225654 GMEB2 -0.66 -9.69 -0.47 1.03e-19 Glioblastoma; LUSC trans rs61931739 0.517 rs10844802 chr12:34231001 C/A cg26384229 chr12:38710491 ALG10B 0.73 11.94 0.55 1.27e-27 Morning vs. evening chronotype; LUSC trans rs2739330 0.828 rs2877178 chr22:24251517 C/T cg06437703 chr8:37914619 EIF4EBP1 -0.55 -8.54 -0.42 4.78e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs61931739 0.534 rs10844729 chr12:34022919 A/G cg13010199 chr12:38710504 ALG10B 0.5 7.71 0.39 1.47e-13 Morning vs. evening chronotype; LUSC cis rs10207060 0.500 rs10181238 chr2:240709496 G/A cg20333904 chr2:240724165 NA -0.37 -6.28 -0.32 1.06e-9 Obesity-related traits; LUSC cis rs11190604 1.000 rs3763695 chr10:102269206 A/G cg07080220 chr10:102295463 HIF1AN 0.68 9.27 0.45 2.29e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12893668 0.645 rs12889403 chr14:104034746 C/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -6.4 -0.33 5.27e-10 Reticulocyte count; LUSC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.87 0.35 3.1e-11 Breast cancer; LUSC cis rs2635047 0.624 rs2289036 chr18:44595809 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -6.23 -0.32 1.37e-9 Educational attainment; LUSC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg09365446 chr1:150670422 GOLPH3L 0.52 7.77 0.39 9.46e-14 Melanoma; LUSC cis rs611744 0.550 rs1448154 chr8:109281053 T/C cg18478394 chr8:109455254 TTC35 0.42 6.53 0.34 2.38e-10 Dupuytren's disease; LUSC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.03 0.44 1.44e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9457247 0.602 rs10484530 chr6:167461562 C/T cg07741184 chr6:167504864 NA 0.49 8.62 0.43 2.75e-16 Crohn's disease; LUSC cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs208520 0.690 rs207119 chr6:66786408 C/T cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs2282802 0.685 rs2053055 chr5:139646776 C/T cg26211634 chr5:139558579 C5orf32 0.45 8.62 0.43 2.79e-16 Intelligence (multi-trait analysis); LUSC cis rs7178572 0.568 rs12907847 chr15:77493174 C/T cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg20503657 chr10:835505 NA 0.76 9.07 0.44 1.02e-17 Eosinophil percentage of granulocytes; LUSC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg22857025 chr5:266934 NA -1.17 -16.85 -0.68 1.53e-46 Breast cancer; LUSC trans rs17685 1.000 rs17685 chr7:75616105 G/A cg19862616 chr7:65841803 NCRNA00174 0.9 13.02 0.58 1.29e-31 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg01579765 chr21:45077557 HSF2BP -0.55 -11.66 -0.54 1.41e-26 Mean corpuscular volume; LUSC cis rs12928939 0.518 rs12445564 chr16:71943309 C/T cg03805757 chr16:71968109 PKD1L3 -0.65 -9.76 -0.47 5.76e-20 Post bronchodilator FEV1; LUSC cis rs4629180 0.701 rs10202801 chr2:102106670 T/C cg04415270 chr2:102091202 RFX8 -0.45 -7.88 -0.4 4.73e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs6076065 0.723 rs2249943 chr20:23378098 A/G cg11657817 chr20:23433608 CST11 0.43 8.03 0.4 1.7e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs7582180 0.934 rs2309822 chr2:100900406 G/A cg08017756 chr2:100939284 LONRF2 -0.34 -5.69 -0.3 2.84e-8 Intelligence (multi-trait analysis); LUSC cis rs950881 0.932 rs10179458 chr2:102934974 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.37 0.33 6.4e-10 Allergy; LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg02353165 chr6:42928485 GNMT 0.68 11.84 0.54 3.07e-27 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg05625103 chr10:2543513 NA 0.47 6.76 0.35 6.24e-11 Age-related hearing impairment; LUSC trans rs62238980 0.522 rs77418985 chr22:32380919 C/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20997706 chr15:74907203 CLK3 -0.43 -6.38 -0.33 5.82e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7771547 0.607 rs584196 chr6:36456243 G/C cg07856975 chr6:36356162 ETV7 0.37 6.58 0.34 1.8e-10 Platelet distribution width; LUSC cis rs12900413 0.687 rs7176981 chr15:90315757 A/G cg24249390 chr15:90295951 MESP1 -0.37 -5.75 -0.3 2.05e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs2227930 0.506 rs1552340 chr3:142015590 A/G cg16271453 chr3:142027066 XRN1 0.54 9.96 0.48 1.26e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs17826219 0.500 rs2874724 chr17:29072433 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Body mass index; LUSC cis rs6582630 0.554 rs8189625 chr12:38401177 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.7 -0.34 8.84e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.51 7.91 0.4 3.88e-14 Menarche (age at onset); LUSC trans rs853679 0.546 rs36116761 chr6:27818482 C/G cg01620082 chr3:125678407 NA -0.82 -7.32 -0.37 1.84e-12 Depression; LUSC cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs7829975 0.509 rs2945269 chr8:8115578 G/C cg11608241 chr8:8085544 FLJ10661 0.44 6.4 0.33 5.18e-10 Mood instability; LUSC cis rs7223966 0.961 rs35844156 chr17:61837568 G/A cg00945038 chr17:61921165 SMARCD2 0.39 5.77 0.3 1.81e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs727505 1.000 rs10226033 chr7:124521430 C/A cg23710748 chr7:124431027 NA -0.42 -7.54 -0.38 4.53e-13 Lewy body disease; LUSC cis rs9303401 0.659 rs2072316 chr17:56604813 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.33 0.59 8.6e-33 Cognitive test performance; LUSC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg21699342 chr2:239360505 ASB1 0.56 10.5 0.5 1.76e-22 Multiple system atrophy; LUSC trans rs747782 0.528 rs4370963 chr11:48433943 C/G cg15704280 chr7:45808275 SEPT13 0.67 6.31 0.33 8.99e-10 Intraocular pressure; LUSC cis rs11676348 0.808 rs4674267 chr2:219046437 C/T cg00012203 chr2:219082015 ARPC2 -0.59 -9.47 -0.46 5.35e-19 Ulcerative colitis; LUSC cis rs559928 0.597 rs2096706 chr11:63924446 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 7.11 0.36 7.16e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9393692 1.000 rs2393593 chr6:26285683 T/C cg13736514 chr6:26305472 NA -0.49 -9.69 -0.47 1e-19 Educational attainment; LUSC cis rs7659604 0.540 rs7698889 chr4:122671324 G/T cg19748678 chr4:122722346 EXOSC9 -0.42 -6.2 -0.32 1.68e-9 Type 2 diabetes; LUSC cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg26384229 chr12:38710491 ALG10B 0.87 14.09 0.61 1.09e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs6547741 0.935 rs4665384 chr2:27848397 A/G cg12559939 chr2:27858050 GPN1 0.39 6.05 0.31 3.98e-9 Oral cavity cancer; LUSC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg06634786 chr22:41940651 POLR3H -0.57 -6.44 -0.33 4.05e-10 Vitiligo; LUSC cis rs10779751 0.734 rs2791657 chr1:11128001 A/G cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs8072100 0.934 rs6504872 chr17:45438952 C/T cg25173405 chr17:45401733 C17orf57 -0.43 -6.83 -0.35 3.91e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs983392 0.679 rs764859 chr11:59978255 C/G cg24026212 chr11:59952134 MS4A6A -0.35 -5.95 -0.31 6.86e-9 Alzheimer's disease (late onset); LUSC cis rs7264396 0.733 rs6058305 chr20:34310757 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.52 -0.46 3.57e-19 Total cholesterol levels; LUSC cis rs4555082 0.789 rs2816649 chr14:105708326 A/G cg06808227 chr14:105710500 BRF1 -0.72 -11.57 -0.53 2.91e-26 Mean platelet volume;Platelet distribution width; LUSC trans rs11098499 0.954 rs66506550 chr4:120371445 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs735396 1.000 rs2464195 chr12:121435475 G/A cg02403541 chr12:121454288 C12orf43 0.61 8.7 0.43 1.53e-16 N-glycan levels; LUSC cis rs61931739 0.635 rs6488185 chr12:33933127 G/C cg06521331 chr12:34319734 NA -0.4 -6.69 -0.34 9.58e-11 Morning vs. evening chronotype; LUSC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs453329 chr20:25440593 G/A cg08601574 chr20:25228251 PYGB 0.43 6.51 0.34 2.83e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg16339924 chr4:17578868 LAP3 0.54 8.14 0.41 7.69e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01029676 chr3:122785968 PDIA5 -0.34 -5.96 -0.31 6.45e-9 Electrocardiographic conduction measures; LUSC cis rs1507153 0.702 rs7740665 chr6:79353465 C/T cg05283184 chr6:79620031 NA -0.42 -7.38 -0.37 1.29e-12 Sjögren's syndrome; LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg17443473 chr1:3703550 LRRC47 0.32 5.65 0.3 3.36e-8 Red cell distribution width; LUSC cis rs72960926 0.744 rs11758445 chr6:74979953 T/A cg03266952 chr6:74778945 NA -0.87 -7.19 -0.37 4.34e-12 Metabolite levels (MHPG); LUSC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg24324837 chr19:49891574 CCDC155 0.44 5.82 0.3 1.36e-8 Multiple sclerosis; LUSC cis rs131777 0.547 rs131753 chr22:51022862 A/G cg00083937 chr22:51039805 MAPK8IP2 0.5 8.41 0.42 1.18e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1866706 0.896 rs7945921 chr11:12875794 C/A cg25843174 chr11:12811716 TEAD1 -0.28 -5.72 -0.3 2.36e-8 Intelligence (multi-trait analysis); LUSC cis rs477692 0.699 rs509017 chr10:131367174 T/G cg05714579 chr10:131428358 MGMT 0.45 6.25 0.32 1.26e-9 Response to temozolomide; LUSC cis rs1904096 0.506 rs6841121 chr4:95222995 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.42 -0.42 1.15e-15 Type 2 diabetes; LUSC cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14442939 chr10:27389572 ANKRD26 0.85 9.79 0.47 4.53e-20 Breast cancer; LUSC cis rs7582180 0.629 rs6736576 chr2:100950854 C/T cg08017756 chr2:100939284 LONRF2 -0.44 -8.27 -0.41 3.33e-15 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.698 rs11153168 chr6:109629420 A/T cg01475377 chr6:109611718 NA -0.37 -5.73 -0.3 2.25e-8 Reticulocyte fraction of red cells; LUSC cis rs3125734 0.633 rs10821968 chr10:63993905 C/T cg09941381 chr10:64027924 RTKN2 0.4 7.4 0.38 1.1e-12 Rheumatoid arthritis; LUSC cis rs8038465 0.622 rs60696711 chr15:73873005 C/A cg15420318 chr15:73925796 NPTN 0.56 9.3 0.45 1.86e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg16393715 chr7:1948819 MAD1L1 0.37 6.33 0.33 7.88e-10 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.866 rs12374244 chr4:120281972 A/T cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC trans rs4714291 0.748 rs3008829 chr6:39953963 C/T cg02267698 chr19:7991119 CTXN1 -0.53 -7.57 -0.38 3.58e-13 Strep throat; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg17968037 chr7:100024898 ZCWPW1 -0.41 -6.14 -0.32 2.39e-9 Platelet count; LUSC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.9e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.91 -0.35 2.4e-11 Menopause (age at onset); LUSC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg04518342 chr5:131593106 PDLIM4 -0.41 -6.95 -0.36 1.88e-11 Breast cancer; LUSC cis rs9300255 0.537 rs1727334 chr12:123714236 A/G cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.94 -0.31 7.31e-9 Neutrophil percentage of white cells; LUSC cis rs1005277 1.000 rs1005277 chr10:38218259 A/C cg13531842 chr10:38383804 ZNF37A 0.42 5.73 0.3 2.22e-8 Extrinsic epigenetic age acceleration; LUSC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs870825 0.616 rs55685500 chr4:185614810 G/A cg04058563 chr4:185651563 MLF1IP 0.88 12.99 0.58 1.67e-31 Blood protein levels; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg04234412 chr22:24373322 LOC391322 -0.87 -14.13 -0.61 7.23e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs974417 0.508 rs986066 chr6:97342489 C/T cg10979063 chr6:97285822 GPR63 0.42 6.71 0.34 8.31e-11 Body mass index; LUSC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg24881330 chr22:46731750 TRMU 0.87 8.8 0.43 7.38e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.92 0.31 8e-9 Intelligence (multi-trait analysis); LUSC cis rs2425143 0.908 rs58448091 chr20:34325470 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.16 -0.32 2.04e-9 Blood protein levels; LUSC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg17264618 chr3:40429014 ENTPD3 0.33 6.79 0.35 5.05e-11 Renal cell carcinoma; LUSC cis rs6964587 1.000 rs2282974 chr7:91761617 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.84 0.3 1.23e-8 Breast cancer; LUSC cis rs941408 0.515 rs2110118 chr19:2775144 T/C cg06609049 chr19:2785107 THOP1 1.13 22.35 0.77 2.74e-68 Total cholesterol levels; LUSC cis rs3784262 0.542 rs2899611 chr15:58327347 A/C cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.67 -0.3 3.12e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6539267 0.741 rs2279759 chr12:106694988 T/C cg00173435 chr12:106696525 TCP11L2 0.61 8.91 0.44 3.32e-17 Tourette syndrome; LUSC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg05855489 chr10:104503620 C10orf26 -0.69 -10.2 -0.49 1.86e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9640161 0.659 rs7788316 chr7:150013995 A/T cg17279839 chr7:150038598 RARRES2 0.42 6.78 0.35 5.45e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2766692 1.000 rs2766690 chr14:100682154 A/G cg14866419 chr14:100704911 YY1 -0.46 -5.86 -0.31 1.12e-8 Electroencephalographic traits in alcoholism; LUSC cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg27446573 chr6:127587934 RNF146 0.91 15.04 0.64 2.2e-39 Breast cancer; LUSC trans rs2055729 0.710 rs112406488 chr8:9736362 T/C cg06636001 chr8:8085503 FLJ10661 0.49 6.19 0.32 1.79e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs4919694 1.000 rs4917379 chr10:104752831 A/T cg04362960 chr10:104952993 NT5C2 1.17 13.66 0.6 4.81e-34 Arsenic metabolism; LUSC cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -7.07 -0.36 9.06e-12 Monocyte percentage of white cells; LUSC cis rs782590 0.967 rs1975484 chr2:55803167 T/A cg03859395 chr2:55845619 SMEK2 0.87 16.06 0.66 1.99e-43 Metabolic syndrome; LUSC cis rs4975709 0.959 rs9312959 chr5:1877008 G/A cg15595755 chr5:1867978 NA 0.38 6.3 0.33 9.61e-10 Cardiovascular disease risk factors; LUSC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg19784903 chr17:45786737 TBKBP1 -0.43 -6.28 -0.33 1.05e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg15605315 chr1:45957053 TESK2 0.45 7.06 0.36 9.83e-12 High light scatter reticulocyte count; LUSC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.13 15.93 0.66 6.52e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2840044 1.000 rs7212704 chr17:33898897 C/T cg19694781 chr19:47549865 TMEM160 0.59 9.52 0.46 3.59e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs950776 0.518 rs28438420 chr15:78836288 A/T cg22563815 chr15:78856949 CHRNA5 -0.23 -5.64 -0.3 3.58e-8 Sudden cardiac arrest; LUSC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.68 -0.39 1.79e-13 Personality dimensions; LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.0 0.36 1.42e-11 Bipolar disorder; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg23131131 chr22:24373011 LOC391322 -0.49 -7.1 -0.36 7.67e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11711311 1.000 rs9811200 chr3:113531180 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.74 -0.3 2.09e-8 IgG glycosylation; LUSC cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg22681709 chr2:178499509 PDE11A -0.51 -9.12 -0.45 7.32e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs61931739 0.929 rs10844748 chr12:34092930 G/T cg06521331 chr12:34319734 NA 0.38 6.52 0.34 2.61e-10 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg10729496 chr3:10149963 C3orf24 0.57 7.74 0.39 1.21e-13 Alzheimer's disease; LUSC cis rs7590368 0.962 rs13431633 chr2:10960225 T/C cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg18876405 chr7:65276391 NA -0.55 -8.79 -0.43 8.32e-17 Aortic root size; LUSC cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg11645453 chr3:52864694 ITIH4 -0.34 -7.74 -0.39 1.17e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7180079 0.925 rs11071789 chr15:64596057 C/T cg08069370 chr15:64387884 SNX1 0.53 5.72 0.3 2.32e-8 Monocyte count; LUSC cis rs1865760 0.566 rs9379821 chr6:26054268 A/C cg17691542 chr6:26056736 HIST1H1C 0.54 8.11 0.41 9.42e-15 Height; LUSC cis rs6964587 0.839 rs12536702 chr7:91471576 G/C cg22709100 chr7:91322751 NA 0.46 6.75 0.35 6.62e-11 Breast cancer; LUSC cis rs3008870 1.000 rs2065000 chr1:67468124 G/C cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg22907277 chr7:1156413 C7orf50 0.72 10.22 0.49 1.63e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7605827 0.930 rs10172344 chr2:15521591 A/G cg19274914 chr2:15703543 NA 0.46 8.98 0.44 2.03e-17 Educational attainment (years of education); LUSC cis rs5769707 0.681 rs135879 chr22:50018651 C/T cg20744362 chr22:50050164 C22orf34 0.38 7.32 0.37 1.87e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7168353 0.948 rs10520720 chr15:93634724 A/G cg12595281 chr15:93633172 RGMA -0.48 -7.56 -0.38 3.89e-13 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs6665290 0.839 rs6699400 chr1:227190497 A/G cg10327440 chr1:227177885 CDC42BPA -1.22 -40.47 -0.91 7.9e-131 Myeloid white cell count; LUSC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg25019033 chr10:957182 NA -0.53 -6.9 -0.35 2.61e-11 Eosinophil percentage of granulocytes; LUSC cis rs757081 0.506 rs11529609 chr11:17063790 G/A cg15084286 chr11:17036142 PLEKHA7 0.49 6.42 0.33 4.6e-10 Systolic blood pressure; LUSC cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg00071950 chr4:10020882 SLC2A9 0.5 8.4 0.42 1.28e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg21573476 chr21:45109991 RRP1B -0.42 -6.75 -0.35 6.5500000000000006e-11 Mean corpuscular volume; LUSC cis rs11608355 1.000 rs10850134 chr12:109861454 G/C cg05360138 chr12:110035743 NA 0.47 6.35 0.33 6.87e-10 Neuroticism; LUSC cis rs4356932 0.935 rs4345214 chr4:76954169 T/C cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg13206674 chr6:150067644 NUP43 0.57 8.99 0.44 1.91e-17 Lung cancer; LUSC cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg03146154 chr1:46216737 IPP -0.57 -8.11 -0.41 9.92e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6543140 0.964 rs10193485 chr2:103089573 T/C cg09003973 chr2:102972529 NA 0.54 6.83 0.35 4.07e-11 Blood protein levels; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg08888203 chr3:10149979 C3orf24 0.66 9.07 0.44 1.06e-17 Alzheimer's disease; LUSC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg09034736 chr1:150693464 HORMAD1 0.49 7.17 0.37 4.82e-12 Melanoma; LUSC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg17644776 chr2:200775616 C2orf69 0.54 9.5 0.46 4.09e-19 Osteoporosis; LUSC cis rs983392 0.667 rs631853 chr11:59944898 T/G cg24026212 chr11:59952134 MS4A6A 0.34 6.2 0.32 1.71e-9 Alzheimer's disease (late onset); LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg22907277 chr7:1156413 C7orf50 0.72 7.67 0.39 1.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs500891 1.000 rs869288 chr6:84190216 A/T cg08257003 chr6:84140564 ME1 0.34 7.06 0.36 9.77e-12 Platelet-derived growth factor BB levels; LUSC cis rs11030122 0.673 rs66596383 chr11:3979745 C/T cg18678763 chr11:4115507 RRM1 -0.43 -5.71 -0.3 2.54e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg06784218 chr1:46089804 CCDC17 0.48 9.5 0.46 4.33e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg01657329 chr11:68192670 LRP5 -0.45 -7.1 -0.36 7.74e-12 Total body bone mineral density; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25336731 chr2:70520884 SNRPG -0.52 -6.92 -0.35 2.31e-11 Bipolar disorder and schizophrenia; LUSC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg06713675 chr4:122721982 EXOSC9 -0.69 -12.06 -0.55 4.59e-28 Type 2 diabetes; LUSC cis rs2857891 0.862 rs957747 chr11:6966814 A/G cg04053776 chr11:6947353 ZNF215 0.49 6.87 0.35 3.14e-11 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs8062405 1.000 rs62036620 chr16:28833097 A/G cg09754948 chr16:28834200 ATXN2L 0.44 6.43 0.33 4.51e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2241584 0.507 rs2913897 chr5:175921783 A/G cg24735937 chr5:175843923 CLTB -0.35 -6.23 -0.32 1.43e-9 Menopause (age at onset); LUSC cis rs10927875 1.000 rs12138117 chr1:16305279 T/C cg21385522 chr1:16154831 NA -0.75 -11.77 -0.54 5.4e-27 Dilated cardiomyopathy; LUSC cis rs977987 0.762 rs1364079 chr16:75393131 C/A cg04384234 chr16:75411784 CFDP1 -0.45 -7.46 -0.38 7.38e-13 Dupuytren's disease; LUSC cis rs9814567 0.806 rs9857995 chr3:134316706 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.77 12.4 0.56 2.66e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs10097669 0.634 rs2725065 chr8:4437566 C/T cg16451306 chr5:71475356 MAP1B 0.29 5.97 0.31 5.98e-9 Trans fatty acid levels; LUSC cis rs921968 0.643 rs552882 chr2:219401726 G/A cg02176678 chr2:219576539 TTLL4 0.64 11.79 0.54 4.45e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs1559088 0.847 rs3786933 chr19:33602881 C/T cg17764715 chr19:33622953 WDR88 0.6 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg27535305 chr1:53392650 SCP2 -0.38 -6.88 -0.35 2.9e-11 Monocyte count; LUSC cis rs9311676 0.632 rs11130643 chr3:58423288 G/A cg13750441 chr3:58318267 PXK 0.34 6.71 0.34 8.48e-11 Systemic lupus erythematosus; LUSC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg21862992 chr11:68658383 NA 0.48 7.69 0.39 1.71e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs61931739 0.500 rs11053203 chr12:34456593 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.74 0.65 3.85e-42 Morning vs. evening chronotype; LUSC cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg22676075 chr6:135203613 NA -0.56 -8.94 -0.44 2.64e-17 Red blood cell count; LUSC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg05855489 chr10:104503620 C10orf26 0.59 9.36 0.46 1.2e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4466137 0.904 rs6887104 chr5:83003535 G/A cg15083037 chr5:83017644 HAPLN1 -0.61 -7.72 -0.39 1.37e-13 Prostate cancer; LUSC cis rs703842 0.739 rs701008 chr12:58117645 A/G cg00677455 chr12:58241039 CTDSP2 0.5 6.82 0.35 4.4e-11 Multiple sclerosis; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg11062466 chr8:58055876 NA 0.69 8.4 0.42 1.34e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg26528668 chr16:1614120 IFT140 0.44 7.25 0.37 2.93e-12 Coronary artery disease; LUSC cis rs208515 0.556 rs12201658 chr6:66678457 T/C cg07460842 chr6:66804631 NA 1.01 13.91 0.61 4.95e-35 Exhaled nitric oxide levels; LUSC cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg15073853 chr19:18549131 ISYNA1 -0.31 -5.72 -0.3 2.4e-8 Breast cancer; LUSC cis rs7851660 0.809 rs7036589 chr9:100657720 A/T cg13688889 chr9:100608707 NA 0.54 8.29 0.41 2.77e-15 Strep throat; LUSC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg00031303 chr3:195681400 NA -0.68 -9.76 -0.47 5.99e-20 Pancreatic cancer; LUSC cis rs9287719 0.934 rs10181806 chr2:10741141 A/G cg00105475 chr2:10696890 NA 0.38 6.35 0.33 6.94e-10 Prostate cancer; LUSC cis rs6541297 1.000 rs6658942 chr1:230287517 A/C cg05784532 chr1:230284198 GALNT2 0.54 8.26 0.41 3.52e-15 Coronary artery disease; LUSC cis rs11756438 0.546 rs9489497 chr6:118999636 T/C cg18833306 chr6:118973337 C6orf204 0.36 5.73 0.3 2.2e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7647973 0.925 rs4955423 chr3:49220448 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.46 6.84 0.35 3.73e-11 Menarche (age at onset); LUSC cis rs7808935 0.958 rs10486567 chr7:27976563 G/A cg22168087 chr7:27702803 HIBADH 0.52 6.54 0.34 2.29e-10 Prostate cancer; LUSC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.97 13.83 0.6 1.02e-34 Smoking behavior; LUSC cis rs12908161 1.000 rs4643294 chr15:85250253 C/T cg17173187 chr15:85201210 NMB 0.51 9.69 0.47 9.71e-20 Schizophrenia; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 4.99e-14 Prudent dietary pattern; LUSC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.83 -0.47 3.36e-20 Gut microbiome composition (summer); LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.13 0.36 6.34e-12 Bipolar disorder; LUSC cis rs7089973 0.604 rs17095662 chr10:116596071 A/C cg25233709 chr10:116636983 FAM160B1 0.37 6.64 0.34 1.24e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg21643547 chr1:205240462 TMCC2 -0.52 -10.11 -0.48 3.84e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4820539 0.966 rs5751587 chr22:23470090 G/A cg14186256 chr22:23484241 RTDR1 0.95 18.06 0.7 2.27e-51 Bone mineral density; LUSC cis rs698813 0.674 rs6759891 chr2:44496005 C/T cg00619915 chr2:44497795 NA -0.51 -6.95 -0.36 1.88e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg18230493 chr5:56204884 C5orf35 -0.62 -9.55 -0.46 2.88e-19 Coronary artery disease; LUSC cis rs7223966 0.921 rs34699959 chr17:61960720 T/G cg11494091 chr17:61959527 GH2 0.38 6.24 0.32 1.31e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.47 8.93 0.44 2.91e-17 Monocyte percentage of white cells; LUSC cis rs4141404 0.923 rs2413035 chr22:31600460 A/G cg22777020 chr22:31556080 RNF185 -0.44 -5.72 -0.3 2.34e-8 Paclitaxel-induced neuropathy; LUSC cis rs10911232 0.507 rs10911212 chr1:183024469 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 11.04 0.52 2.31e-24 Hypertriglyceridemia; LUSC cis rs892961 0.932 rs3987886 chr17:75414980 A/G cg05865280 chr17:75406074 SEPT9 0.46 9.61 0.47 1.86e-19 Airflow obstruction; LUSC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg12756686 chr19:29218302 NA 0.46 5.81 0.3 1.42e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2282802 0.685 rs12717951 chr5:139589309 A/G cg26211634 chr5:139558579 C5orf32 0.43 8.03 0.4 1.63e-14 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg12463550 chr7:65579703 CRCP 0.51 7.39 0.37 1.2e-12 Aortic root size; LUSC cis rs11997175 0.545 rs7839592 chr8:33666662 T/C ch.8.33884649F chr8:33765107 NA 0.5 7.19 0.37 4.32e-12 Body mass index; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg03354898 chr7:1950403 MAD1L1 -0.43 -8.63 -0.43 2.57e-16 Bipolar disorder and schizophrenia; LUSC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.85 0.54 2.87e-27 Personality dimensions; LUSC cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.85 0.39 5.8e-14 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08470185 chr1:1334798 CCNL2;LOC148413 -0.39 -6.24 -0.32 1.29e-9 Electrocardiographic conduction measures; LUSC cis rs59698941 0.943 rs10491278 chr5:132220436 A/C cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.45e-11 Apolipoprotein A-IV levels; LUSC cis rs637571 0.522 rs649000 chr11:65742933 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.67 0.39 1.84e-13 Eosinophil percentage of white cells; LUSC cis rs10761482 0.861 rs10761490 chr10:62108666 T/G cg18175470 chr10:62150864 ANK3 -0.5 -7.1 -0.36 7.67e-12 Schizophrenia; LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg27284194 chr4:1044797 NA 0.35 5.83 0.3 1.32e-8 Obesity-related traits; LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 14.24 0.61 2.83e-36 Platelet count; LUSC cis rs10769945 0.679 rs217213 chr11:1979118 C/G cg06197492 chr11:2016605 H19 -0.37 -6.19 -0.32 1.79e-9 DNA methylation (variation); LUSC cis rs250677 0.687 rs250663 chr5:148453117 T/C cg23229984 chr5:148520753 ABLIM3 0.41 6.45 0.33 3.99e-10 Breast cancer; LUSC cis rs290268 1.000 rs188313 chr9:93548302 C/T cg02608019 chr9:93564028 SYK 0.54 8.98 0.44 1.98e-17 Platelet count; LUSC cis rs1577917 0.696 rs10806334 chr6:86439329 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -7.54 -0.38 4.39e-13 Response to antipsychotic treatment; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg21030970 chr17:45798741 NA 0.37 6.27 0.32 1.14e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23932593 chr6:133135524 RPS12;SNORD101 -0.52 -6.5 -0.34 2.98e-10 Bipolar disorder and schizophrenia; LUSC cis rs56283067 0.671 rs1028608 chr6:44681721 C/T cg18551225 chr6:44695536 NA -0.42 -7.36 -0.37 1.48e-12 Total body bone mineral density; LUSC cis rs68170813 0.559 rs80341862 chr7:106934731 C/G cg02696742 chr7:106810147 HBP1 -0.65 -9.98 -0.48 1.09e-20 Coronary artery disease; LUSC cis rs6740322 1.000 rs11693666 chr2:43562479 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.44 6.15 0.32 2.17e-9 Coronary artery disease; LUSC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg06850241 chr22:41845214 NA 0.3 5.77 0.3 1.84e-8 Vitiligo; LUSC cis rs28374715 0.532 rs28463309 chr15:41666716 A/G cg18705301 chr15:41695430 NDUFAF1 -1.03 -23.32 -0.79 4.71e-72 Ulcerative colitis; LUSC cis rs113835537 0.529 rs117112180 chr11:66293273 A/G cg24851651 chr11:66362959 CCS 0.52 7.41 0.38 1.05e-12 Airway imaging phenotypes; LUSC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs17685 0.672 rs6465011 chr7:75811297 T/C cg19862616 chr7:65841803 NCRNA00174 1.08 17.76 0.7 3.61e-50 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10493773 1.000 rs55654440 chr1:86176158 G/C cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.35 -0.46 1.28e-18 Urate levels in overweight individuals; LUSC cis rs12210905 1.000 rs7757680 chr6:27005840 T/C cg23155468 chr6:27110703 HIST1H2BK -0.69 -6.01 -0.31 4.74e-9 Hip circumference adjusted for BMI; LUSC cis rs9672608 0.687 rs5019044 chr15:78796282 T/A cg06917634 chr15:78832804 PSMA4 -0.51 -5.95 -0.31 6.63e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.66e-12 Resting heart rate; LUSC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg04369109 chr6:150039330 LATS1 -0.53 -7.66 -0.39 2.03e-13 Lung cancer; LUSC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.1e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs6500602 0.598 rs3859155 chr16:4593741 A/C cg08645402 chr16:4508243 NA -0.42 -6.88 -0.35 2.9e-11 Schizophrenia; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg00535420 chr2:238875533 UBE2F 0.43 6.1 0.32 2.86e-9 Mosquito bite size; LUSC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.66 10.48 0.5 2.16e-22 Cognitive test performance; LUSC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg12365402 chr11:9010492 NRIP3 -0.49 -9.15 -0.45 5.85e-18 Hemoglobin concentration; LUSC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg08219700 chr8:58056026 NA 0.44 5.75 0.3 2.01e-8 Developmental language disorder (linguistic errors); LUSC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg10909506 chr17:38081995 ORMDL3 0.32 5.75 0.3 2.04e-8 Self-reported allergy; LUSC cis rs9916302 0.706 rs7208252 chr17:37584368 A/G cg07936489 chr17:37558343 FBXL20 -0.8 -9.76 -0.47 5.85e-20 Glomerular filtration rate (creatinine); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10774877 chr13:102068989 NALCN -0.39 -6.12 -0.32 2.59e-9 Triglycerides; LUSC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg10130564 chr11:117069849 TAGLN 0.31 6.0 0.31 5.07e-9 Blood protein levels; LUSC cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg10253484 chr15:75165896 SCAMP2 -0.59 -8.29 -0.41 2.85e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9527 0.590 rs11191572 chr10:104893137 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs5770917 1.000 rs2073605 chr22:51008850 A/G cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.9 -0.31 8.76e-9 Narcolepsy; LUSC cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.93 -0.31 7.69e-9 IgG glycosylation; LUSC cis rs4789693 0.938 rs4789694 chr17:80428099 A/C cg04308225 chr17:80449738 NA -0.48 -7.68 -0.39 1.81e-13 Glucocorticoid-induced osteonecrosis; LUSC trans rs208515 0.525 rs10944859 chr6:66665197 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.03 14.08 0.61 1.14e-35 Exhaled nitric oxide levels; LUSC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs73416724 1.000 rs76649578 chr6:43388024 A/G cg26312998 chr6:43337775 ZNF318 0.53 6.15 0.32 2.23e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs546131 0.928 rs552627 chr11:34826680 G/A cg06937548 chr11:34938143 PDHX;APIP 0.45 6.3 0.33 9.48e-10 Lung disease severity in cystic fibrosis; LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.89 0.61 6.08e-35 Platelet count; LUSC cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg12011299 chr4:100065546 ADH4 0.72 11.06 0.52 1.99e-24 Alcohol dependence; LUSC cis rs7584330 0.826 rs72620824 chr2:238381083 G/A cg14458575 chr2:238380390 NA 0.84 14.2 0.61 3.77e-36 Prostate cancer; LUSC cis rs4566357 0.595 rs1320406 chr2:227920474 C/T cg11843606 chr2:227700838 RHBDD1 -0.51 -7.61 -0.38 2.86e-13 Coronary artery disease; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg05368731 chr17:41323189 NBR1 0.93 16.11 0.66 1.32e-43 Menopause (age at onset); LUSC trans rs629535 0.814 rs56301437 chr8:70108518 C/T cg21567404 chr3:27674614 NA -0.98 -15.88 -0.66 1.02e-42 Dupuytren's disease; LUSC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg18904891 chr8:8559673 CLDN23 0.61 8.47 0.42 7.74e-16 Obesity-related traits; LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg16606324 chr3:10149918 C3orf24 -0.53 -7.42 -0.38 9.95e-13 Alzheimer's disease; LUSC cis rs2708377 0.858 rs68045377 chr12:11294452 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.81 7.88 0.4 4.71e-14 Bitter taste perception; LUSC trans rs12200782 0.932 rs72844476 chr6:26574150 C/T cg11837749 chr1:55047332 ACOT11 0.57 6.14 0.32 2.32e-9 Small cell lung carcinoma; LUSC cis rs13315871 0.929 rs11720747 chr3:58267833 G/A cg12435725 chr3:58293450 RPP14 -0.82 -7.88 -0.4 4.7e-14 Cholesterol, total; LUSC cis rs72792276 0.818 rs3805610 chr5:127487719 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 6.32 0.33 8.61e-10 Red cell distribution width; LUSC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg13798780 chr7:105162888 PUS7 0.54 6.03 0.31 4.24e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11890956 chr21:40555474 PSMG1 -0.86 -15.07 -0.64 1.58e-39 Cognitive function; LUSC cis rs1595825 0.891 rs2045244 chr2:198506466 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -5.78 -0.3 1.69e-8 Ulcerative colitis; LUSC cis rs17270561 0.609 rs9393665 chr6:25744284 G/A cg16482183 chr6:26056742 HIST1H1C 0.63 9.07 0.44 1.01e-17 Iron status biomarkers; LUSC cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs8092503 1.000 rs2015502 chr18:52489982 A/G cg12377874 chr18:52495404 RAB27B -0.34 -6.29 -0.33 1.01e-9 Childhood body mass index; LUSC cis rs6496667 0.533 rs2601206 chr15:90962699 C/T cg22089800 chr15:90895588 ZNF774 0.52 7.48 0.38 6.67e-13 Rheumatoid arthritis; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs9467711 0.591 rs72834617 chr6:25999175 G/A cg16898833 chr6:26189333 HIST1H4D 0.64 6.14 0.32 2.39e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs8073060 0.586 rs225298 chr17:33923946 T/G cg19694781 chr19:47549865 TMEM160 -1.15 -18.63 -0.71 1.22e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7202877 0.610 rs468079 chr16:75428474 G/A cg04384234 chr16:75411784 CFDP1 0.69 9.97 0.48 1.11e-20 Type 2 diabetes;Type 1 diabetes; LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg25427524 chr10:38739819 LOC399744 0.44 7.47 0.38 7.18e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs72634258 0.945 rs12748993 chr1:8129507 A/G cg26816564 chr1:7831052 VAMP3 0.44 5.73 0.3 2.21e-8 Inflammatory bowel disease; LUSC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg24399712 chr22:39784796 NA -0.64 -11.85 -0.54 2.84e-27 Intelligence (multi-trait analysis); LUSC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg27572855 chr1:25598939 RHD -0.42 -7.5 -0.38 5.92e-13 Erythrocyte sedimentation rate; LUSC cis rs576982 1 rs576982 chr15:78870803 C/T cg24631222 chr15:78858424 CHRNA5 0.68 9.08 0.44 9.58e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg09796270 chr17:17721594 SREBF1 0.43 7.65 0.39 2.17e-13 Total body bone mineral density; LUSC cis rs500891 0.525 rs1170484 chr6:84038522 A/G cg08257003 chr6:84140564 ME1 0.33 7.8 0.39 7.82e-14 Platelet-derived growth factor BB levels; LUSC cis rs7605827 0.897 rs11682528 chr2:15533183 T/C cg19274914 chr2:15703543 NA 0.48 9.34 0.46 1.39e-18 Educational attainment (years of education); LUSC cis rs3733418 0.799 rs13110766 chr4:165956628 C/T cg06481168 chr4:165878055 C4orf39;TRIM61 -0.45 -5.79 -0.3 1.6e-8 Obesity-related traits; LUSC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.05 0.48 6.03e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.909 rs11098530 chr4:120413154 C/T cg09307838 chr4:120376055 NA 0.79 11.8 0.54 4.37e-27 Corneal astigmatism; LUSC cis rs9303401 0.659 rs16943326 chr17:57050365 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.03 0.58 1.12e-31 Cognitive test performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10007002 chr8:38126881 PPAPDC1B -0.4 -5.96 -0.31 6.46e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9611565 0.918 rs2281333 chr22:41749630 T/C cg03806693 chr22:41940476 POLR3H -0.76 -11.0 -0.52 3.06e-24 Vitiligo; LUSC cis rs4604732 0.578 rs12040725 chr1:247644697 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.59 0.34 1.7e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs10089 1.000 rs1864922 chr5:127420700 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.89 12.55 0.57 7.02e-30 Ileal carcinoids; LUSC trans rs7647973 0.626 rs6809879 chr3:49834571 A/G cg21659725 chr3:3221576 CRBN 0.69 8.29 0.41 2.82e-15 Menarche (age at onset); LUSC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs35995292 0.927 rs4720308 chr7:38914285 A/C cg19327137 chr7:38886074 VPS41 0.34 5.71 0.3 2.47e-8 Subjective well-being (multi-trait analysis); LUSC cis rs72772090 0.539 rs72775810 chr5:96185307 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.79 -0.35 5.01e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3125734 0.633 rs4979754 chr10:64048959 G/A cg19640130 chr10:64028056 RTKN2 -0.39 -6.8 -0.35 4.7e-11 Rheumatoid arthritis; LUSC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4680 1.000 rs4680 chr22:19951271 C/T cg23601416 chr22:19950040 COMT 0.29 6.09 0.32 3.16e-9 Blood metabolite levels; LUSC cis rs2046867 0.818 rs17690720 chr3:72866030 T/C cg25664220 chr3:72788482 NA -0.71 -11.97 -0.55 9.97e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs524023 0.957 rs12365089 chr11:64364735 A/T cg07220939 chr11:64358617 SLC22A12 -0.22 -5.69 -0.3 2.71e-8 Urate levels in obese individuals; LUSC cis rs734999 0.545 rs28568531 chr1:2555640 T/A cg18854424 chr1:2615690 NA 0.49 9.85 0.47 2.88e-20 Ulcerative colitis; LUSC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg19230755 chr7:65878503 NA -0.42 -6.0 -0.31 5.22e-9 Aortic root size; LUSC trans rs61931739 0.534 rs1608911 chr12:34010249 T/C cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 3.03e-25 Morning vs. evening chronotype; LUSC cis rs34779708 0.931 rs34876468 chr10:35424450 G/A cg04310649 chr10:35416472 CREM -0.43 -6.64 -0.34 1.29e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2692947 0.727 rs2692950 chr2:96673524 T/C cg22654517 chr2:96458247 NA 0.3 5.85 0.3 1.16e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg25427524 chr10:38739819 LOC399744 -0.58 -10.24 -0.49 1.4e-21 Extrinsic epigenetic age acceleration; LUSC cis rs1023500 0.573 rs13057094 chr22:42470317 T/C cg05082376 chr22:42548792 NA -0.38 -5.67 -0.3 3.09e-8 Schizophrenia; LUSC trans rs1459104 0.789 rs28896554 chr11:54812637 C/T cg15704280 chr7:45808275 SEPT13 0.75 6.55 0.34 2.23e-10 Body mass index; LUSC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.81 0.39 7.22e-14 Bipolar disorder; LUSC cis rs782590 0.967 rs4290693 chr2:55799991 C/G cg18811423 chr2:55921094 PNPT1 0.81 14.09 0.61 1.06e-35 Metabolic syndrome; LUSC cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg10978503 chr1:24200527 CNR2 0.47 11.12 0.52 1.18e-24 Immature fraction of reticulocytes; LUSC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg04455712 chr21:45112962 RRP1B 0.45 8.5 0.42 6.21e-16 Mean corpuscular volume; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg14004847 chr7:1930337 MAD1L1 -0.58 -9.11 -0.45 7.51e-18 Bipolar disorder and schizophrenia; LUSC cis rs4343996 0.727 rs4722696 chr7:3374580 C/G cg21248987 chr7:3385318 SDK1 -0.35 -6.04 -0.31 4.12e-9 Motion sickness; LUSC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.62 -0.5 6.98e-23 Obesity-related traits; LUSC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg12963246 chr6:28129442 ZNF389 0.4 6.22 0.32 1.53e-9 Parkinson's disease; LUSC cis rs72829446 0.556 rs10048219 chr17:7403792 C/T cg02795151 chr17:7402630 POLR2A 0.63 7.81 0.39 7.61e-14 Androgen levels; LUSC cis rs11098499 0.779 rs28495013 chr4:120375831 A/C cg24375607 chr4:120327624 NA 0.79 11.71 0.54 8.83e-27 Corneal astigmatism; LUSC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg01943577 chr7:158741284 NA -0.39 -5.7 -0.3 2.6e-8 Height; LUSC cis rs757110 0.590 rs7484027 chr11:17368381 T/A cg01251548 chr11:17372745 DKFZp686O24166 0.34 6.54 0.34 2.29e-10 Type 2 diabetes; LUSC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg06238570 chr21:40685208 BRWD1 0.47 7.25 0.37 2.94e-12 Cognitive function; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg00024416 chr22:24240387 NA -0.33 -5.69 -0.3 2.81e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.44 -0.42 9.51e-16 Cystic fibrosis severity; LUSC cis rs9399401 0.626 rs1928528 chr6:142779109 T/G cg04461802 chr6:142623433 GPR126 0.46 5.9 0.31 8.82e-9 Chronic obstructive pulmonary disease; LUSC cis rs295140 1.000 rs11888462 chr2:201160499 G/T cg04283868 chr2:201171347 SPATS2L 0.45 6.85 0.35 3.58e-11 QT interval; LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.38 0.37 1.3e-12 Bipolar disorder; LUSC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -5.67 -0.3 3.05e-8 Developmental language disorder (linguistic errors); LUSC cis rs2267681 0.565 rs6464800 chr7:139518480 A/G cg14116596 chr7:139528673 TBXAS1 0.38 6.63 0.34 1.34e-10 Cervical cancer; LUSC trans rs2624839 0.679 rs2624835 chr3:50209049 G/A cg21659725 chr3:3221576 CRBN 0.42 6.16 0.32 2.06e-9 Intelligence (multi-trait analysis); LUSC cis rs9479482 1.000 rs9478354 chr6:150334366 G/A cg07578070 chr6:150326732 RAET1K 0.39 5.99 0.31 5.43e-9 Alopecia areata; LUSC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg27432699 chr2:27873401 GPN1 -0.58 -8.67 -0.43 1.84e-16 Total body bone mineral density; LUSC cis rs9815354 0.812 rs60659106 chr3:41949569 G/C cg03022575 chr3:42003672 ULK4 0.81 8.49 0.42 6.81e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs8099014 0.906 rs4940695 chr18:56106483 T/G cg12907477 chr18:56117327 MIR122 0.43 6.36 0.33 6.77e-10 Platelet count; LUSC cis rs561341 0.739 rs8070554 chr17:30216868 A/T cg13647721 chr17:30228624 UTP6 -0.68 -7.84 -0.39 5.94e-14 Hip circumference adjusted for BMI; LUSC cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.4 -6.85 -0.35 3.63e-11 Neutrophil percentage of white cells; LUSC cis rs2072499 0.966 rs2853643 chr1:156184831 G/A cg24450063 chr1:156163899 SLC25A44 1.15 23.5 0.79 8.98e-73 Testicular germ cell tumor; LUSC cis rs12464483 0.524 rs2593470 chr2:30887402 G/T cg12454169 chr2:30669597 LCLAT1 0.6 8.0 0.4 2.03e-14 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs6750047 0.647 rs62136320 chr2:38275953 T/G cg07380506 chr2:38303506 CYP1B1 0.47 6.54 0.34 2.27e-10 Cutaneous malignant melanoma;Melanoma; LUSC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg17971929 chr21:40555470 PSMG1 0.65 7.99 0.4 2.23e-14 Cognitive function; LUSC trans rs61931739 0.500 rs6488222 chr12:34526289 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg25039879 chr17:56429692 SUPT4H1 -0.47 -6.81 -0.35 4.58e-11 Cognitive test performance; LUSC cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg21475434 chr5:93447410 FAM172A 0.76 9.17 0.45 5.12e-18 Diabetic retinopathy; LUSC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg16989086 chr20:62203971 PRIC285 0.46 6.53 0.34 2.47e-10 Glioblastoma; LUSC trans rs2262909 0.962 rs439574 chr19:22232024 A/C cg17074339 chr11:11642133 GALNTL4 -0.4 -6.17 -0.32 1.95e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7539542 0.556 rs10732292 chr1:202891366 T/C cg19681188 chr1:202830198 LOC148709 0.41 6.11 0.32 2.85e-9 Mean platelet volume; LUSC cis rs72949976 1.000 rs72949976 chr2:214034104 C/T cg08319019 chr2:214017104 IKZF2 -0.62 -9.61 -0.47 1.87e-19 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs929596 0.785 rs11695484 chr2:234654449 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.71 -12.31 -0.56 5.71e-29 Total bilirubin levels in HIV-1 infection; LUSC cis rs7113850 0.541 rs77868378 chr11:24233684 C/T ch.11.24196551F chr11:24239977 NA 1.01 9.09 0.45 8.71e-18 Bone fracture in osteoporosis; LUSC cis rs2294693 0.945 rs742494 chr6:41007835 A/T cg14769373 chr6:40998127 UNC5CL -0.54 -7.23 -0.37 3.27e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs6690583 0.623 rs12030730 chr1:85454109 C/G cg22153463 chr1:85462885 MCOLN2 0.61 5.88 0.31 1.02e-8 Serum sulfate level; LUSC cis rs2795502 0.564 rs11239842 chr10:43444882 A/G cg08461752 chr10:43522343 NA -0.55 -6.45 -0.33 3.85e-10 Blood protein levels; LUSC cis rs9467773 1.000 rs1535277 chr6:26567802 G/T cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC cis rs6714710 0.603 rs13023980 chr2:98502987 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.18e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs1865721 0.804 rs72977816 chr18:73146779 A/T cg26385618 chr18:73139727 C18orf62 -0.52 -9.66 -0.47 1.24e-19 Intelligence; LUSC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg03732007 chr1:2071316 PRKCZ 0.54 9.88 0.48 2.28e-20 Height; LUSC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg03354898 chr7:1950403 MAD1L1 -0.31 -5.94 -0.31 7.04e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg08999081 chr20:33150536 PIGU -0.41 -7.56 -0.38 3.88e-13 Glomerular filtration rate (creatinine); LUSC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -7.29 -0.37 2.23e-12 Developmental language disorder (linguistic errors); LUSC cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg11584989 chr19:19387371 SF4 -0.64 -7.6 -0.38 2.99e-13 Bipolar disorder; LUSC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -10.08 -0.48 4.74e-21 Developmental language disorder (linguistic errors); LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.3 -5.66 -0.3 3.27e-8 Lymphocyte counts; LUSC cis rs1538970 0.884 rs61788261 chr1:45899114 G/A cg05343316 chr1:45956843 TESK2 0.65 8.91 0.44 3.31e-17 Platelet count; LUSC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg17990871 chr1:1677678 SLC35E2 -0.41 -6.33 -0.33 7.81e-10 Body mass index; LUSC cis rs11209185 0.509 rs9436356 chr1:68447202 A/G cg22082780 chr1:68452167 NA 0.44 7.23 0.37 3.27e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs12950390 0.853 rs11079791 chr17:45859099 C/T cg06532163 chr17:45867833 NA 0.33 6.27 0.32 1.1e-9 IgG glycosylation; LUSC cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg23173402 chr1:227635558 NA 0.6 7.19 0.37 4.24e-12 Major depressive disorder; LUSC cis rs7927771 0.524 rs10742814 chr11:47554337 G/A cg20307385 chr11:47447363 PSMC3 0.44 6.46 0.33 3.7e-10 Subjective well-being; LUSC cis rs9486719 0.947 rs72932805 chr6:96902933 T/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.81 -0.47 4e-20 Migraine;Coronary artery disease; LUSC cis rs17401966 0.838 rs12738317 chr1:10419663 C/T cg19773385 chr1:10388646 KIF1B -0.5 -8.68 -0.43 1.82e-16 Hepatocellular carcinoma; LUSC cis rs425277 0.959 rs77665022 chr1:2065958 C/T cg03732007 chr1:2071316 PRKCZ 0.49 7.79 0.39 8.55e-14 Height; LUSC cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg06784218 chr1:46089804 CCDC17 0.48 9.2 0.45 3.91e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs9300255 0.679 rs10846507 chr12:123786492 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -5.64 -0.3 3.55e-8 Neutrophil percentage of white cells; LUSC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg05585544 chr11:47624801 NA -0.41 -7.29 -0.37 2.3e-12 Subjective well-being; LUSC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg18758796 chr5:131593413 PDLIM4 0.34 5.83 0.3 1.31e-8 Blood metabolite levels; LUSC cis rs730566 0.640 rs6442112 chr3:48316034 A/G cg11946769 chr3:48343235 NME6 0.49 6.39 0.33 5.47e-10 Prion diseases; LUSC cis rs7943203 0.539 rs12226046 chr11:108335940 G/C cg04873221 chr11:107992290 ACAT1 -0.39 -5.77 -0.3 1.77e-8 Red blood cell count;Mean corpuscular volume; LUSC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 1.9e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7264396 0.563 rs78084033 chr20:34219990 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.09 -0.4 1.12e-14 Total cholesterol levels; LUSC cis rs2235649 0.666 rs2076429 chr16:1817935 A/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 0.47 5.88 0.31 1.01e-8 Blood metabolite levels; LUSC cis rs9467773 1.000 rs1321479 chr6:26501897 C/T cg09904177 chr6:26538194 HMGN4 -0.71 -12.72 -0.57 1.76e-30 Intelligence (multi-trait analysis); LUSC cis rs244731 1.000 rs244731 chr5:176539679 C/T cg17509989 chr5:176798049 RGS14 0.72 9.1 0.45 8.34e-18 Urate levels in lean individuals; LUSC cis rs1448094 0.717 rs7298614 chr12:86296513 C/T cg02569458 chr12:86230093 RASSF9 0.51 8.34 0.42 1.95e-15 Major depressive disorder; LUSC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg06008330 chr7:65541103 ASL -0.4 -6.2 -0.32 1.66e-9 Aortic root size; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg23131131 chr22:24373011 LOC391322 -0.5 -7.24 -0.37 3.06e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1595825 0.891 rs16825786 chr2:198794681 G/T cg00982548 chr2:198649783 BOLL -0.57 -7.29 -0.37 2.32e-12 Ulcerative colitis; LUSC cis rs9300255 0.596 rs11057202 chr12:123720775 G/T cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.78 -0.35 5.48e-11 Neutrophil percentage of white cells; LUSC cis rs2455601 0.766 rs1109304 chr11:8955455 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -7.42 -0.38 9.97e-13 Schizophrenia; LUSC cis rs9875589 0.509 rs1488379 chr3:14014719 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 7.02 0.36 1.24e-11 Ovarian reserve; LUSC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg03676636 chr4:99064102 C4orf37 0.3 6.48 0.33 3.32e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7659604 0.540 rs10012775 chr4:122676878 T/C cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC trans rs2386661 0.603 rs11259704 chr10:5646999 C/T cg11398623 chr21:37499189 NA 0.26 5.96 0.31 6.31e-9 Breast cancer; LUSC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg10295955 chr4:187884368 NA -1.07 -25.94 -0.82 4.9e-82 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg06221963 chr1:154839813 KCNN3 0.63 14.56 0.62 1.53e-37 Prostate cancer; LUSC cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg12011299 chr4:100065546 ADH4 0.71 10.85 0.51 1.08e-23 Smoking initiation; LUSC cis rs6429082 0.818 rs834198 chr1:235671987 A/G cg26050004 chr1:235667680 B3GALNT2 0.62 8.33 0.41 2.17e-15 Adiposity; LUSC trans rs1325195 0.537 rs2636289 chr1:179169815 T/A cg11624085 chr17:8464688 MYH10 0.43 6.38 0.33 5.94e-10 IgE grass sensitization; LUSC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg10295955 chr4:187884368 NA -1.06 -23.74 -0.79 1.09e-73 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.34 0.67 1.63e-44 Gut microbiome composition (summer); LUSC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.74e-40 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.865 rs2389809 chr4:120377399 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.43 0.33 4.35e-10 Corneal astigmatism; LUSC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.78 -0.35 5.4e-11 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03526160 chr20:43586170 TOMM34 0.34 5.96 0.31 6.45e-9 Electrocardiographic conduction measures; LUSC cis rs12210905 0.925 rs12190201 chr6:27001458 A/C cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.74e-9 Hip circumference adjusted for BMI; LUSC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg22029157 chr1:209979665 IRF6 0.71 8.65 0.43 2.19e-16 Cleft lip with or without cleft palate; LUSC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs9469578 0.892 rs73743333 chr6:33714042 G/A cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs9325144 0.647 rs4616077 chr12:39092364 T/C cg13010199 chr12:38710504 ALG10B -0.52 -7.98 -0.4 2.44e-14 Morning vs. evening chronotype; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg18402987 chr7:1209562 NA 0.72 7.76 0.39 1.07e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9473924 1.000 rs9473932 chr6:50857995 G/A cg22375689 chr19:34175036 CHST8 0.38 6.15 0.32 2.27e-9 Body mass index; LUSC cis rs950169 0.922 rs11635505 chr15:85097034 A/C cg12863693 chr15:85201151 NMB -0.34 -7.06 -0.36 9.82e-12 Schizophrenia; LUSC cis rs6494488 0.500 rs72742999 chr15:65010510 G/A cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg22834771 chr12:69754056 YEATS4 -0.52 -7.78 -0.39 9.09e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs3849570 0.925 rs13091492 chr3:81891476 A/G cg07356753 chr3:81810745 GBE1 -0.63 -9.75 -0.47 6.21e-20 Waist circumference;Body mass index; LUSC cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.22 0.49 1.61e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg06558623 chr16:89946397 TCF25 1.1 9.73 0.47 7.28e-20 Skin colour saturation; LUSC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 10.22 0.49 1.57e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg26528668 chr16:1614120 IFT140 0.45 7.63 0.39 2.44e-13 Coronary artery disease; LUSC cis rs12618769 0.652 rs3769708 chr2:99187650 T/C cg10123293 chr2:99228465 UNC50 0.47 7.52 0.38 5.11e-13 Bipolar disorder; LUSC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg03233332 chr7:66118400 NA 0.41 6.05 0.31 3.95e-9 Aortic root size; LUSC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg23758822 chr17:41437982 NA -1.0 -19.84 -0.74 1.95e-58 Menopause (age at onset); LUSC cis rs7954584 0.567 rs11043246 chr12:122368944 G/A cg22618164 chr12:122356400 WDR66 0.62 9.23 0.45 3.21e-18 Mean corpuscular volume; LUSC cis rs72781680 1.000 rs72796358 chr2:24160132 T/A cg08917208 chr2:24149416 ATAD2B 0.91 10.01 0.48 8.69e-21 Lymphocyte counts; LUSC cis rs1577917 0.958 rs11752180 chr6:86573165 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.86 -0.44 4.73e-17 Response to antipsychotic treatment; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg02018176 chr4:1364513 KIAA1530 0.47 8.16 0.41 6.75e-15 Obesity-related traits; LUSC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg17971929 chr21:40555470 PSMG1 0.53 8.33 0.41 2.19e-15 Cognitive function; LUSC cis rs1595825 0.891 rs73056811 chr2:198766642 T/C cg10547527 chr2:198650123 BOLL -0.49 -5.72 -0.3 2.32e-8 Ulcerative colitis; LUSC cis rs6546550 0.935 rs60207187 chr2:70093910 G/A cg02498382 chr2:70120550 SNRNP27 -0.29 -7.17 -0.37 4.97e-12 Prevalent atrial fibrillation; LUSC cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg00071950 chr4:10020882 SLC2A9 0.66 11.12 0.52 1.19e-24 Bone mineral density; LUSC cis rs7712401 0.601 rs418229 chr5:122341664 T/C cg19077854 chr5:122220652 SNX24 -0.43 -9.25 -0.45 2.68e-18 Mean platelet volume; LUSC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg11941060 chr3:133502564 NA 0.55 8.28 0.41 2.92e-15 Iron status biomarkers; LUSC cis rs17401966 0.838 rs12737239 chr1:10323973 C/G cg19773385 chr1:10388646 KIF1B -0.5 -8.74 -0.43 1.19e-16 Hepatocellular carcinoma; LUSC cis rs17001868 0.568 rs470113 chr22:40729614 A/G cg07138101 chr22:40742427 ADSL 0.6 7.25 0.37 2.87e-12 Mammographic density (dense area); LUSC cis rs16867321 0.614 rs12693245 chr2:181445110 T/C cg23363182 chr2:181467187 NA 0.57 9.2 0.45 4.03e-18 Obesity; LUSC trans rs12637928 0.518 rs6767880 chr3:110151810 T/C cg17371621 chr15:61264283 RORA 0.38 6.44 0.33 4.19e-10 Neuroticism; LUSC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.21e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7824557 0.767 rs3808509 chr8:11163256 G/T cg21293242 chr8:11204541 TDH 0.32 5.97 0.31 6.23e-9 Retinal vascular caliber; LUSC cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg25427524 chr10:38739819 LOC399744 -0.59 -10.81 -0.51 1.51e-23 Extrinsic epigenetic age acceleration; LUSC cis rs7119 0.717 rs8033067 chr15:77825495 G/T cg27398640 chr15:77910606 LINGO1 -0.32 -6.68 -0.34 9.78e-11 Type 2 diabetes; LUSC trans rs979233 0.502 rs276242 chr5:42060518 C/G cg07010552 chr17:7358735 CHRNB1 -0.41 -5.95 -0.31 6.62e-9 Systemic lupus erythematosus; LUSC cis rs9790314 1.000 rs4350933 chr3:160955879 G/T cg03342759 chr3:160939853 NMD3 -0.52 -8.75 -0.43 1.1e-16 Morning vs. evening chronotype; LUSC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.89e-12 Blood metabolite levels; LUSC cis rs2625529 0.652 rs2957728 chr15:72236432 G/T cg16672083 chr15:72433130 SENP8 0.49 8.15 0.41 7.45e-15 Red blood cell count; LUSC cis rs4853525 0.923 rs7582941 chr2:191728900 A/T cg11845111 chr2:191398756 TMEM194B -0.41 -6.05 -0.31 3.83e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg08392591 chr16:89556376 ANKRD11 0.43 6.38 0.33 5.82e-10 Multiple myeloma (IgH translocation); LUSC cis rs17102423 1.000 rs4902364 chr14:65602006 G/A cg11161011 chr14:65562177 MAX -0.65 -10.09 -0.48 4.6e-21 Obesity-related traits; LUSC cis rs6028335 0.502 rs8114962 chr20:37635979 A/G cg27552599 chr20:37590471 DHX35 0.45 7.51 0.38 5.57e-13 Alcohol and nicotine co-dependence; LUSC cis rs929354 0.772 rs2023977 chr7:156996022 C/G cg05182265 chr7:156933206 UBE3C -0.6 -9.63 -0.47 1.63e-19 Body mass index; LUSC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg24110177 chr3:50126178 RBM5 -0.55 -9.07 -0.44 1e-17 Intelligence (multi-trait analysis); LUSC cis rs4851254 0.660 rs60697219 chr2:100699507 G/A cg07810366 chr2:100720526 AFF3 -0.46 -6.16 -0.32 2.05e-9 Intelligence (multi-trait analysis); LUSC cis rs983392 0.679 rs1019671 chr11:60008151 T/C cg20284999 chr11:59952153 MS4A6A -0.35 -5.75 -0.3 2.03e-8 Alzheimer's disease (late onset); LUSC trans rs61931739 0.534 rs2389276 chr12:34097891 T/C cg13010199 chr12:38710504 ALG10B 0.54 8.05 0.4 1.48e-14 Morning vs. evening chronotype; LUSC cis rs7267979 0.868 rs6138546 chr20:25216534 G/A cg08601574 chr20:25228251 PYGB 0.5 7.7 0.39 1.56e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7100689 0.784 rs7895042 chr10:82095276 G/A cg00277334 chr10:82204260 NA -0.54 -7.57 -0.38 3.69e-13 Post bronchodilator FEV1; LUSC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg13114125 chr14:105738426 BRF1 -0.91 -16.06 -0.66 1.98e-43 Mean platelet volume;Platelet distribution width; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg26668828 chr6:292823 DUSP22 -0.73 -12.25 -0.56 9.81e-29 Menopause (age at onset); LUSC cis rs17818399 0.962 rs7565274 chr2:46841861 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.42 -5.7 -0.3 2.58e-8 Height; LUSC cis rs12545109 0.613 rs6998873 chr8:57299697 A/G cg09654669 chr8:57350985 NA 0.46 6.13 0.32 2.51e-9 Obesity-related traits; LUSC trans rs11700980 0.551 rs56166203 chr21:30109607 G/C cg14791747 chr16:20752902 THUMPD1 0.56 6.15 0.32 2.24e-9 QRS complex (12-leadsum); LUSC cis rs7937682 0.632 rs11603779 chr11:111781047 A/C cg09085632 chr11:111637200 PPP2R1B 0.93 12.62 0.57 3.86e-30 Primary sclerosing cholangitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03150463 chr7:108166687 PNPLA8 -0.42 -6.18 -0.32 1.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10435719 0.834 rs11250176 chr8:11792816 A/G cg08975724 chr8:8085496 FLJ10661 0.48 6.96 0.36 1.79e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13184582 chr1:169075593 ATP1B1 -0.41 -6.03 -0.31 4.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2835872 0.758 rs1787396 chr21:39036487 A/C cg20424643 chr21:39039972 KCNJ6 -0.45 -7.57 -0.38 3.65e-13 Electroencephalographic traits in alcoholism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13927387 chr11:101980807 YAP1 -0.38 -5.98 -0.31 5.72e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs568617 0.767 rs2231884 chr11:65656564 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.62 7.3 0.37 2.17e-12 Crohn's disease; LUSC cis rs35000415 0.938 rs17339836 chr7:128681062 C/T cg19972273 chr7:128594194 NA 0.67 6.75 0.35 6.46e-11 Systemic lupus erythematosus; LUSC cis rs17688076 0.511 rs2418738 chr16:68122604 G/C cg26727032 chr16:67993705 SLC12A4 -0.42 -5.84 -0.3 1.25e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); LUSC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11644478 chr21:40555479 PSMG1 -0.8 -14.53 -0.62 2.15e-37 Cognitive function; LUSC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs782590 0.643 rs13009906 chr2:55739434 A/G cg03859395 chr2:55845619 SMEK2 -0.68 -10.48 -0.5 2.05e-22 Metabolic syndrome; LUSC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg24399712 chr22:39784796 NA -0.63 -11.83 -0.54 3.33e-27 Intelligence (multi-trait analysis); LUSC cis rs9547692 1.000 rs9531991 chr13:37470945 A/G cg01493522 chr13:37497338 NA -0.44 -6.35 -0.33 7.07e-10 Coronary artery disease; LUSC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg22535103 chr8:58192502 C8orf71 -0.74 -9.28 -0.45 2.18e-18 Developmental language disorder (linguistic errors); LUSC cis rs2835872 0.727 rs2835831 chr21:38987233 T/C cg20424643 chr21:39039972 KCNJ6 0.37 5.71 0.3 2.51e-8 Electroencephalographic traits in alcoholism; LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13126279 chr21:47581558 C21orf56 -0.56 -8.67 -0.43 1.86e-16 Testicular germ cell tumor; LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC trans rs7937682 0.924 rs10891286 chr11:111532691 C/G cg18187862 chr3:45730750 SACM1L 0.55 7.04 0.36 1.11e-11 Primary sclerosing cholangitis; LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg09877947 chr5:131593287 PDLIM4 0.55 9.05 0.44 1.17e-17 Acylcarnitine levels; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg00149659 chr3:10157352 C3orf10 0.97 12.89 0.58 4.01e-31 Alzheimer's disease; LUSC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs1801251 1.000 rs283474 chr2:233654627 A/G cg08000102 chr2:233561755 GIGYF2 0.75 11.91 0.55 1.71e-27 Coronary artery disease; LUSC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg03806693 chr22:41940476 POLR3H 0.9 12.63 0.57 3.59e-30 Vitiligo; LUSC cis rs67460515 0.892 rs1382429 chr3:161015153 T/C cg03342759 chr3:160939853 NMD3 -0.52 -7.38 -0.37 1.24e-12 Parkinson's disease; LUSC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg24060327 chr5:131705240 SLC22A5 -0.43 -7.15 -0.36 5.49e-12 Blood metabolite levels; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg03188948 chr7:1209495 NA 0.62 6.43 0.33 4.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.03e-17 Prudent dietary pattern; LUSC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs8192482 1 rs8192482 chr15:78886198 C/T cg18825076 chr15:78729989 IREB2 -0.49 -7.64 -0.39 2.28e-13 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg26441486 chr22:50317300 CRELD2 -0.53 -8.01 -0.4 1.93e-14 Schizophrenia; LUSC trans rs11997175 0.583 rs4739562 chr8:33844064 C/T cg00636124 chr16:27215281 JMJD5 -0.45 -6.14 -0.32 2.35e-9 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07182965 chr18:71815169 FBXO15;C18orf55 -0.4 -6.2 -0.32 1.7e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10489525 0.550 rs6659415 chr1:115632211 C/T cg01522456 chr1:115632236 TSPAN2 0.71 10.48 0.5 2.08e-22 Autism; LUSC cis rs1322512 0.917 rs2623942 chr6:152951118 T/A cg27316956 chr6:152958899 SYNE1 -0.36 -6.14 -0.32 2.28e-9 Tonometry; LUSC cis rs7584330 0.822 rs13390494 chr2:238388792 G/A cg16989719 chr2:238392110 NA -0.42 -7.12 -0.36 6.7e-12 Prostate cancer; LUSC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg08798685 chr6:27730294 NA 0.54 5.8 0.3 1.52e-8 Depression; LUSC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg16325326 chr1:53192061 ZYG11B -0.99 -19.96 -0.74 6.94e-59 Monocyte count; LUSC cis rs10883723 0.669 rs2001595 chr10:104395085 C/T cg22532475 chr10:104410764 TRIM8 -0.4 -8.38 -0.42 1.47e-15 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs11677416 1.000 rs1516790 chr2:113531291 G/A cg27083787 chr2:113543245 IL1A 0.46 7.27 0.37 2.57e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs950776 0.518 rs12903129 chr15:78819606 C/T cg06917634 chr15:78832804 PSMA4 0.81 14.35 0.62 1.08e-36 Sudden cardiac arrest; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00510360 chr3:108308232 KIAA1524;DZIP3 0.45 6.23 0.32 1.39e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs68170813 0.559 rs12535258 chr7:106971050 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.64 -0.47 1.47e-19 Coronary artery disease; LUSC cis rs9905704 0.681 rs1860262 chr17:56580997 T/C cg19466818 chr17:56409534 MIR142 0.38 6.99 0.36 1.53e-11 Testicular germ cell tumor; LUSC cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg05283184 chr6:79620031 NA -0.57 -11.52 -0.53 4.53e-26 Intelligence (multi-trait analysis); LUSC cis rs751728 0.965 rs4713681 chr6:33754817 T/C cg25922239 chr6:33757077 LEMD2 0.53 8.01 0.4 1.99e-14 Crohn's disease; LUSC cis rs911555 0.755 rs8014013 chr14:103937372 A/G cg24130564 chr14:104152367 KLC1 0.45 6.31 0.33 9.04e-10 Intelligence (multi-trait analysis); LUSC cis rs12893668 0.703 rs4906335 chr14:104021141 C/A cg04998671 chr14:104000505 TRMT61A -0.46 -6.59 -0.34 1.75e-10 Reticulocyte count; LUSC trans rs561341 1.000 rs757009 chr17:30243937 A/G cg27661571 chr11:113659931 NA -0.53 -6.31 -0.33 8.71e-10 Hip circumference adjusted for BMI; LUSC trans rs7618501 0.633 rs6446193 chr3:50059758 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.55 -8.91 -0.44 3.36e-17 Intelligence (multi-trait analysis); LUSC cis rs9326248 0.689 rs4516002 chr11:116999059 A/G cg26566898 chr11:117069891 TAGLN 0.43 6.08 0.32 3.21e-9 Blood protein levels; LUSC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg24879335 chr3:133465180 TF 0.46 7.91 0.4 3.93e-14 Iron status biomarkers (transferrin levels); LUSC cis rs2235642 0.717 rs9937922 chr16:1658154 C/G cg09025071 chr16:1593152 IFT140;TMEM204 0.33 7.66 0.39 2.05e-13 Coronary artery disease; LUSC cis rs796364 0.760 rs11690371 chr2:200989616 A/G cg23649088 chr2:200775458 C2orf69 -0.53 -6.46 -0.33 3.79e-10 Schizophrenia; LUSC cis rs6542838 0.611 rs13006398 chr2:99522323 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.48 -0.33 3.38e-10 Fear of minor pain; LUSC cis rs7246967 0.673 rs16994997 chr19:22879610 T/G cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs1697139 1.000 rs1697139 chr5:66511535 A/G cg11553311 chr5:66541588 NA 0.31 5.84 0.3 1.27e-8 Breast cancer; LUSC cis rs73200209 0.744 rs17426676 chr12:116595512 T/C cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs7481584 0.624 rs436580 chr11:3063961 T/G cg08508325 chr11:3079039 CARS 0.38 8.66 0.43 2e-16 Calcium levels; LUSC cis rs3768617 0.510 rs3765522 chr1:183077618 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.83 0.51 1.26e-23 Fuchs's corneal dystrophy; LUSC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.94 -0.35 2.11e-11 Electroencephalogram traits; LUSC cis rs10911363 0.659 rs2275676 chr1:183430822 C/G cg09173681 chr1:183549694 NCF2 -0.63 -11.19 -0.52 6.48e-25 Systemic lupus erythematosus; LUSC cis rs11608355 0.618 rs12227736 chr12:109796637 G/A cg19025524 chr12:109796872 NA -0.49 -8.91 -0.44 3.46e-17 Neuroticism; LUSC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.28 0.37 2.45e-12 Mean platelet volume; LUSC cis rs611744 0.647 rs579162 chr8:109254842 A/G cg18478394 chr8:109455254 TTC35 0.41 6.29 0.33 9.7e-10 Dupuytren's disease; LUSC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg03909863 chr11:638404 DRD4 -0.4 -5.86 -0.31 1.09e-8 Systemic lupus erythematosus; LUSC cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs2274273 0.624 rs7159824 chr14:55772536 C/T cg04306507 chr14:55594613 LGALS3 0.49 10.03 0.48 7.04e-21 Protein biomarker; LUSC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg02221750 chr19:17393354 ANKLE1 -0.89 -14.03 -0.61 1.7000000000000001e-35 Systemic lupus erythematosus; LUSC cis rs9811920 0.535 rs1610509 chr3:99474327 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.3 5.84 0.3 1.23e-8 Axial length; LUSC cis rs9287719 0.967 rs7608498 chr2:10738428 G/A cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs1256061 0.603 rs960069 chr14:64745002 C/T cg21174375 chr14:64681225 SYNE2 0.35 6.3 0.33 9.23e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg05785598 chr3:49045655 WDR6 0.32 5.85 0.3 1.18e-8 Parkinson's disease; LUSC cis rs9457247 0.544 rs6920858 chr6:167464630 G/A cg25258033 chr6:167368657 RNASET2 0.44 6.61 0.34 1.53e-10 Crohn's disease; LUSC cis rs1160297 0.576 rs10206560 chr2:53089060 G/C cg07782112 chr2:53107842 NA 0.4 6.47 0.33 3.53e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs240768 1.000 rs2398133 chr6:101004751 A/G cg12253828 chr6:101329408 ASCC3 0.84 5.74 0.3 2.11e-8 Economic and political preferences (immigration/crime); LUSC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg03929089 chr4:120376271 NA -1.05 -20.64 -0.75 1.33e-61 Height; LUSC cis rs4839421 0.934 rs12046828 chr1:111017477 C/G cg06880108 chr1:111021908 CYMP 0.45 7.5 0.38 5.91e-13 Response to bupropion in depression; LUSC cis rs10754283 0.935 rs1934046 chr1:90119290 A/T cg21401794 chr1:90099060 LRRC8C -0.64 -9.16 -0.45 5.23e-18 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9326248 0.581 rs7121898 chr11:116796846 A/T cg16524733 chr11:117070046 TAGLN 0.3 5.65 0.3 3.47e-8 Blood protein levels; LUSC cis rs713477 0.692 rs8019270 chr14:55907172 C/G cg13175173 chr14:55914753 NA -0.31 -6.16 -0.32 2.13e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.73 0.3 2.25e-8 Intelligence (multi-trait analysis); LUSC cis rs9467773 1.000 rs1884948 chr6:26567988 G/A cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.666 rs7396059 chr11:970490 C/A ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.41e-10 Alzheimer's disease (late onset); LUSC cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.52 0.38 5.1e-13 Rheumatoid arthritis; LUSC cis rs4478858 0.735 rs10914344 chr1:31769025 T/C cg00250761 chr1:31883323 NA -0.33 -8.0 -0.4 2.07e-14 Alcohol dependence; LUSC cis rs6696846 0.703 rs112653854 chr1:205079251 G/T cg03948781 chr1:205179583 DSTYK 0.33 6.43 0.33 4.38e-10 Red blood cell count; LUSC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg16414030 chr3:133502952 NA -0.39 -5.85 -0.3 1.17e-8 Iron status biomarkers; LUSC cis rs2625529 0.652 rs2929525 chr15:72287856 G/A cg16672083 chr15:72433130 SENP8 0.5 8.26 0.41 3.38e-15 Red blood cell count; LUSC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg20135002 chr11:47629003 NA -0.49 -7.66 -0.39 2.01e-13 Subjective well-being; LUSC cis rs7759001 0.857 rs6456777 chr6:27365994 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC trans rs11039798 0.588 rs1814768 chr11:48987455 T/C cg15704280 chr7:45808275 SEPT13 0.73 8.3 0.41 2.64e-15 Axial length; LUSC cis rs9527 0.590 rs2281877 chr10:104866062 C/T cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs12530845 0.887 rs4492299 chr7:135315690 T/G cg23117316 chr7:135346802 PL-5283 -0.57 -9.27 -0.45 2.4e-18 Red blood cell traits; LUSC cis rs12908161 0.959 rs34028043 chr15:85231585 G/A cg17173187 chr15:85201210 NMB 0.51 9.66 0.47 1.24e-19 Schizophrenia; LUSC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg06637938 chr14:75390232 RPS6KL1 0.52 8.2 0.41 5.08e-15 Height; LUSC cis rs6783573 0.535 rs12637699 chr3:46628443 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.41 -7.05 -0.36 1e-11 Cerebrospinal fluid biomarker levels; LUSC trans rs877282 0.898 rs12356709 chr10:763365 A/G cg22713356 chr15:30763199 NA 1.05 13.89 0.61 5.97e-35 Uric acid levels; LUSC cis rs4820539 0.902 rs4822359 chr22:23474972 A/G cg14186256 chr22:23484241 RTDR1 0.95 17.85 0.7 1.59e-50 Bone mineral density; LUSC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg21724239 chr8:58056113 NA 0.74 6.34 0.33 7.54e-10 Developmental language disorder (linguistic errors); LUSC cis rs2303282 0.933 rs4783941 chr16:56511736 C/T cg00500540 chr16:56394104 NA 0.46 7.4 0.38 1.14e-12 Breast cancer; LUSC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg00990874 chr7:1149470 C7orf50 -0.59 -8.09 -0.4 1.15e-14 Bronchopulmonary dysplasia; LUSC cis rs1153858 0.723 rs1719238 chr15:45594766 C/T cg26924012 chr15:45694286 SPATA5L1 -1.08 -17.53 -0.69 3.03e-49 Homoarginine levels; LUSC cis rs6674970 0.627 rs2864700 chr1:151028929 C/T cg11822372 chr1:151115635 SEMA6C 0.36 5.74 0.3 2.09e-8 Childhood ear infection; LUSC cis rs9463078 0.565 rs10948183 chr6:44880881 T/C cg25276700 chr6:44698697 NA 0.29 6.06 0.31 3.72e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4588572 0.644 rs6870646 chr5:77741082 G/A cg11547950 chr5:77652471 NA -0.46 -6.74 -0.35 7.08e-11 Triglycerides; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10598066 chr11:44087808 ACCS -0.49 -7.47 -0.38 7.1e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg15073853 chr19:18549131 ISYNA1 -0.33 -5.98 -0.31 5.66e-9 Breast cancer; LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg00945038 chr17:61921165 SMARCD2 0.5 8.83 0.44 5.87e-17 Prudent dietary pattern; LUSC cis rs1413885 0.549 rs1334879 chr1:65846051 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.47 6.77 0.35 5.79e-11 Anticoagulant levels; LUSC trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg06636001 chr8:8085503 FLJ10661 -0.61 -9.15 -0.45 5.61e-18 Neuroticism; LUSC cis rs2073300 0.826 rs6048809 chr20:23443788 C/T cg09953122 chr20:23471693 CST8 -0.73 -6.86 -0.35 3.41e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs62103177 0.565 rs473119 chr18:77849459 T/G cg05926928 chr17:57297772 GDPD1 -0.9 -10.32 -0.49 7.58e-22 Opioid sensitivity; LUSC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg24531977 chr5:56204891 C5orf35 -0.98 -14.21 -0.61 3.53e-36 Initial pursuit acceleration; LUSC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg17971929 chr21:40555470 PSMG1 0.77 13.53 0.6 1.44e-33 Cognitive function; LUSC cis rs11625487 0.645 rs8006951 chr14:77965304 G/A cg16049707 chr14:77965284 ISM2 0.6 8.58 0.42 3.72e-16 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs2348418 0.864 rs7960369 chr12:28714502 T/C cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 7.51 0.38 5.46e-13 Schizophrenia; LUSC cis rs10072221 0.836 rs4254886 chr5:75706939 T/C cg03132911 chr5:75698732 IQGAP2 0.36 6.08 0.32 3.36e-9 Mean platelet volume; LUSC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.94 -0.35 2.09e-11 Lung cancer; LUSC trans rs3960554 0.673 rs112680895 chr7:75623520 G/A cg19862616 chr7:65841803 NCRNA00174 0.89 10.25 0.49 1.26e-21 Eotaxin levels; LUSC cis rs9549260 0.816 rs964901 chr13:41248698 C/T cg21288729 chr13:41239152 FOXO1 0.58 8.7 0.43 1.56e-16 Red blood cell count; LUSC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC trans rs11098499 1.000 rs7659194 chr4:120207147 T/G cg25214090 chr10:38739885 LOC399744 0.48 7.14 0.36 6.01e-12 Corneal astigmatism; LUSC cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg01420254 chr6:26195488 NA 0.64 6.96 0.36 1.79e-11 Gout;Renal underexcretion gout; LUSC cis rs10779751 0.734 rs2039840 chr1:11125866 G/A cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs11674184 0.714 rs9789525 chr2:11724580 G/T cg07314298 chr2:11723111 GREB1 -0.78 -15.0 -0.63 3.1e-39 Endometriosis; LUSC cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg04450456 chr4:17643702 FAM184B 0.39 6.54 0.34 2.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10193935 0.901 rs12615383 chr2:42610551 A/G cg27598129 chr2:42591480 NA 0.62 8.26 0.41 3.52e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs12530845 1.000 rs77068811 chr7:135334571 A/G cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg08645402 chr16:4508243 NA 0.48 7.48 0.38 6.64e-13 Schizophrenia; LUSC cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg00321850 chr1:175162397 KIAA0040 0.44 7.42 0.38 1.01e-12 Alcohol dependence; LUSC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg11764359 chr7:65958608 NA -0.69 -11.1 -0.52 1.42e-24 Aortic root size; LUSC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg10523679 chr1:76189770 ACADM 0.84 11.01 0.52 2.85e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs804280 0.509 rs13268030 chr8:11783073 C/T cg21775007 chr8:11205619 TDH 0.47 6.83 0.35 4.05e-11 Myopia (pathological); LUSC cis rs11756438 0.572 rs2638529 chr6:119006459 T/C cg21191810 chr6:118973309 C6orf204 0.34 5.76 0.3 1.91e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg03477792 chr4:77819574 ANKRD56 -0.58 -8.45 -0.42 9.27e-16 Emphysema distribution in smoking; LUSC cis rs5769707 0.967 rs9616713 chr22:50049109 G/A cg07959070 chr22:50026188 C22orf34 -0.36 -7.41 -0.38 1.05e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.23 0.32 1.42e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs5758511 0.773 rs73165164 chr22:42355549 T/C cg00645731 chr22:42541494 CYP2D7P1 0.43 7.13 0.36 6.12e-12 Birth weight; LUSC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC cis rs8077889 0.917 rs1859048 chr17:41892039 A/C cg26893861 chr17:41843967 DUSP3 -0.85 -13.28 -0.59 1.26e-32 Triglycerides; LUSC cis rs7827545 1.000 rs6578229 chr8:135562453 T/G cg17885191 chr8:135476712 NA 0.56 8.33 0.41 2.07e-15 Hypertension (SNP x SNP interaction); LUSC cis rs4356932 0.902 rs28548768 chr4:76972755 T/C cg00809888 chr4:76862425 NAAA 0.34 5.78 0.3 1.75e-8 Blood protein levels; LUSC cis rs13082711 0.911 rs4973770 chr3:27425815 C/T cg02860705 chr3:27208620 NA 0.49 8.38 0.42 1.53e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg13798912 chr7:905769 UNC84A -0.57 -5.89 -0.31 9.23e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg11102782 chr19:18549136 ISYNA1 -0.36 -6.84 -0.35 3.89e-11 Breast cancer; LUSC cis rs9473147 0.602 rs9296567 chr6:47553402 G/A cg12968598 chr6:47444699 CD2AP 0.52 7.98 0.4 2.3e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs1348850 0.632 rs13008833 chr2:178514439 G/C cg22681709 chr2:178499509 PDE11A -0.59 -11.79 -0.54 4.53e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs11989744 0.500 rs7826517 chr8:23568841 G/A cg03492747 chr16:86543808 FOXF1 -0.64 -11.12 -0.52 1.23e-24 Waist-hip ratio; LUSC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg21918786 chr6:109611834 NA -0.41 -7.06 -0.36 9.89e-12 Reticulocyte fraction of red cells; LUSC cis rs981844 0.712 rs10009854 chr4:154741785 C/T cg14289246 chr4:154710475 SFRP2 -0.44 -6.13 -0.32 2.5e-9 Response to statins (LDL cholesterol change); LUSC cis rs854765 0.624 rs12952723 chr17:17731651 T/C cg09796270 chr17:17721594 SREBF1 -0.45 -7.95 -0.4 2.89e-14 Total body bone mineral density; LUSC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg04352962 chr1:209979756 IRF6 0.56 6.65 0.34 1.19e-10 Cleft lip with or without cleft palate; LUSC cis rs78663649 0.708 rs115656720 chr19:16622921 C/A cg10248733 chr19:16607483 C19orf44;CALR3 -0.89 -6.53 -0.34 2.47e-10 White blood cell count; LUSC cis rs2979489 0.786 rs1106352 chr8:30404671 C/T cg26383811 chr8:30366931 RBPMS -0.49 -7.71 -0.39 1.42e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg21918786 chr6:109611834 NA -0.34 -5.84 -0.3 1.24e-8 Reticulocyte fraction of red cells; LUSC trans rs6076960 0.846 rs6053962 chr20:6176915 A/G cg21095983 chr6:86352623 SYNCRIP 0.41 6.33 0.33 7.92e-10 Smooth-surface caries; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg12432903 chr7:1882776 MAD1L1 -0.36 -5.72 -0.3 2.37e-8 Bipolar disorder and schizophrenia; LUSC cis rs1348850 0.645 rs7571386 chr2:178442687 A/C cg23306229 chr2:178417860 TTC30B 0.53 6.01 0.31 4.88e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg13395646 chr4:1353034 KIAA1530 -0.64 -10.09 -0.48 4.43e-21 Obesity-related traits; LUSC cis rs599083 0.530 rs686921 chr11:68170833 G/T cg01657329 chr11:68192670 LRP5 0.5 6.64 0.34 1.24e-10 Bone mineral density (spine); LUSC cis rs7098414 0.511 rs10887828 chr10:82151470 T/C cg00277334 chr10:82204260 NA -0.59 -9.81 -0.47 4.05e-20 Post bronchodilator FEV1; LUSC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg00933542 chr6:150070202 PCMT1 0.33 6.77 0.35 5.98e-11 Lung cancer; LUSC cis rs500891 0.597 rs9449619 chr6:84168161 A/G cg08257003 chr6:84140564 ME1 0.35 8.41 0.42 1.25e-15 Platelet-derived growth factor BB levels; LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg08859206 chr1:53392774 SCP2 0.5 8.51 0.42 6.03e-16 Monocyte count; LUSC cis rs9807841 0.544 rs10407692 chr19:10770783 A/G cg09936142 chr19:10668400 KRI1 -0.4 -6.46 -0.33 3.74e-10 Inflammatory skin disease; LUSC cis rs1003719 0.762 rs1155786 chr21:38448025 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.29 0.53 3.03e-25 Eye color traits; LUSC cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs7681440 0.904 rs58864428 chr4:90766986 T/C cg01966878 chr4:90757139 SNCA -0.35 -6.05 -0.31 3.97e-9 Dementia with Lewy bodies; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.47 -8.12 -0.41 8.88e-15 Lymphocyte counts; LUSC cis rs4746818 1.000 rs4746818 chr10:70884687 G/T cg11621586 chr10:70884670 VPS26A 1.09 14.25 0.61 2.52e-36 Left atrial antero-posterior diameter; LUSC cis rs6906287 0.625 rs7764280 chr6:118692514 A/G cg21191810 chr6:118973309 C6orf204 0.38 6.85 0.35 3.67e-11 Electrocardiographic conduction measures; LUSC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg02782426 chr3:40428986 ENTPD3 -0.3 -5.89 -0.31 9.39e-9 Renal cell carcinoma; LUSC cis rs1881396 0.531 rs72613829 chr2:27902987 C/T cg27432699 chr2:27873401 GPN1 0.63 7.54 0.38 4.62e-13 Nonalcoholic fatty liver disease; LUSC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg13902645 chr11:5959945 NA -0.56 -7.86 -0.4 5.2e-14 DNA methylation (variation); LUSC cis rs2795502 1.000 rs2744092 chr10:43339343 T/C cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg00071950 chr4:10020882 SLC2A9 -0.52 -8.77 -0.43 9.54e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg04756594 chr16:24857601 SLC5A11 -0.5 -7.36 -0.37 1.42e-12 Intelligence (multi-trait analysis); LUSC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.51 -6.88 -0.35 2.95e-11 Height; LUSC cis rs2245008 0.950 rs824400 chr16:83989936 C/G cg27171569 chr16:83987465 OSGIN1 -0.64 -11.14 -0.52 1.03e-24 Pursuit maintenance gain; LUSC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.75 13.5 0.59 1.88e-33 Intelligence (multi-trait analysis); LUSC cis rs11785400 0.793 rs11785376 chr8:143730412 C/T cg24634471 chr8:143751801 JRK 0.51 7.25 0.37 2.97e-12 Schizophrenia; LUSC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg26597838 chr10:835615 NA 0.95 12.71 0.57 1.86e-30 Eosinophil percentage of granulocytes; LUSC cis rs1044826 0.956 rs13086868 chr3:139239644 A/G cg00490450 chr3:139108681 COPB2 0.54 6.96 0.36 1.85e-11 Obesity-related traits; LUSC cis rs3755132 0.568 rs16862882 chr2:15808632 C/G cg12888861 chr2:15731646 DDX1 0.49 5.85 0.31 1.15e-8 Wilms tumor; LUSC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg03806693 chr22:41940476 POLR3H 0.99 14.14 0.61 6.88e-36 Vitiligo; LUSC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.8 -0.39 8.06e-14 Height; LUSC cis rs6733011 0.508 rs6542843 chr2:99533729 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.17 -0.32 1.93e-9 Bipolar disorder; LUSC cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.51 -0.34 2.73e-10 High light scatter reticulocyte count; LUSC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg01097406 chr16:89675127 NA -0.38 -7.63 -0.39 2.41e-13 Vitiligo; LUSC cis rs9341808 0.538 rs7747327 chr6:81035774 G/T cg08355045 chr6:80787529 NA -0.43 -7.32 -0.37 1.84e-12 Sitting height ratio; LUSC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.2 -0.32 1.62e-9 Life satisfaction; LUSC cis rs3771570 1.000 rs56052835 chr2:242243251 T/G cg21155796 chr2:242212141 HDLBP 0.67 7.52 0.38 5.23e-13 Prostate cancer; LUSC cis rs6547741 0.935 rs6761095 chr2:27778010 G/T cg27432699 chr2:27873401 GPN1 0.82 15.29 0.64 2.21e-40 Oral cavity cancer; LUSC cis rs57920188 0.640 rs4478781 chr1:4086827 C/T cg20703997 chr1:4087676 NA 0.6 8.24 0.41 3.92e-15 Interleukin-17 levels; LUSC cis rs806215 0.951 rs327521 chr7:127249143 G/A cg25922125 chr7:127225783 GCC1 0.5 6.46 0.33 3.78e-10 Type 2 diabetes; LUSC cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.65 -0.43 2.19e-16 Axial length; LUSC cis rs7582180 0.564 rs2309795 chr2:100954290 G/A cg12002119 chr2:101014098 CHST10 0.35 5.88 0.31 1.02e-8 Intelligence (multi-trait analysis); LUSC cis rs68170813 0.559 rs4730231 chr7:106942039 G/C cg02696742 chr7:106810147 HBP1 -0.64 -9.7 -0.47 8.88e-20 Coronary artery disease; LUSC cis rs295140 0.934 rs74853338 chr2:201171651 C/T cg04283868 chr2:201171347 SPATS2L 0.44 6.63 0.34 1.36e-10 QT interval; LUSC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg05347473 chr6:146136440 FBXO30 -0.66 -11.37 -0.53 1.55e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.88 0.31 9.85e-9 Menopause (age at onset); LUSC cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg12011299 chr4:100065546 ADH4 0.74 12.54 0.57 8.27e-30 Alcohol dependence; LUSC trans rs1728785 1.000 rs1645976 chr16:68563509 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg17264618 chr3:40429014 ENTPD3 0.34 7.32 0.37 1.87e-12 Renal cell carcinoma; LUSC cis rs61931739 0.500 rs11053210 chr12:34461771 A/G cg06521331 chr12:34319734 NA 0.39 6.06 0.31 3.61e-9 Morning vs. evening chronotype; LUSC cis rs9467773 0.967 rs7753565 chr6:26560012 A/G cg09904177 chr6:26538194 HMGN4 0.75 14.03 0.61 1.84e-35 Intelligence (multi-trait analysis); LUSC cis rs922692 0.773 rs2869861 chr15:79076744 A/G cg00540400 chr15:79124168 NA -0.41 -7.06 -0.36 9.95e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs12545109 0.732 rs1973629 chr8:57429583 A/G cg09654669 chr8:57350985 NA -0.5 -6.28 -0.33 1.04e-9 Obesity-related traits; LUSC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -6.55 -0.34 2.17e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg00316803 chr15:76480434 C15orf27 -0.4 -6.8 -0.35 4.95e-11 Blood metabolite levels; LUSC cis rs60012524 1 rs60012524 chr2:99559117 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.98 -12.75 -0.57 1.32e-30 Chronic sinus infection; LUSC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg13683864 chr3:40499215 RPL14 1.13 23.04 0.78 5.38e-71 Renal cell carcinoma; LUSC cis rs10779751 0.734 rs7533211 chr1:11132965 G/C cg08854313 chr1:11322531 MTOR 0.8 12.36 0.56 3.82e-29 Body mass index; LUSC cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Bone mineral density; LUSC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg05425664 chr17:57184151 TRIM37 -0.58 -8.82 -0.43 6.32e-17 Intelligence (multi-trait analysis); LUSC cis rs9527 0.590 rs7067663 chr10:104883650 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC trans rs6951245 1.000 rs78158942 chr7:1090440 G/T cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg15147215 chr3:52552868 STAB1 -0.32 -6.21 -0.32 1.56e-9 Bipolar disorder; LUSC cis rs72634258 0.520 rs12078018 chr1:7857309 G/A cg26816564 chr1:7831052 VAMP3 0.97 13.38 0.59 5.36e-33 Inflammatory bowel disease; LUSC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg13939156 chr17:80058883 NA 0.35 7.15 0.36 5.64e-12 Life satisfaction; LUSC trans rs7939886 0.920 rs77391761 chr11:55814896 G/C cg15704280 chr7:45808275 SEPT13 0.83 6.92 0.35 2.38e-11 Myopia (pathological); LUSC cis rs7605827 0.930 rs11685629 chr2:15662271 A/T cg19274914 chr2:15703543 NA 0.46 8.89 0.44 3.78e-17 Educational attainment (years of education); LUSC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11644478 chr21:40555479 PSMG1 -0.66 -10.17 -0.49 2.51e-21 Menarche (age at onset); LUSC cis rs7712401 0.601 rs30059 chr5:122297509 G/A cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg15506890 chr2:3487001 NA -0.57 -9.38 -0.46 1.06e-18 Neurofibrillary tangles; LUSC cis rs9814567 0.896 rs11915964 chr3:134348930 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.88 0.6 6.63e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9549260 0.755 rs2755219 chr13:41169625 A/G cg21288729 chr13:41239152 FOXO1 0.59 8.94 0.44 2.71e-17 Red blood cell count; LUSC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg04287289 chr16:89883240 FANCA 0.5 7.42 0.38 9.91e-13 Vitiligo; LUSC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg04025307 chr7:1156635 C7orf50 0.46 6.18 0.32 1.86e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg05347473 chr6:146136440 FBXO30 0.59 9.73 0.47 7.37e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.6 9.32 0.45 1.68e-18 Height; LUSC cis rs2303282 0.716 rs2550307 chr16:56414131 A/G cg00500540 chr16:56394104 NA -0.44 -7.57 -0.38 3.6e-13 Breast cancer; LUSC cis rs7937682 0.632 rs10789850 chr11:111750829 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.47 0.56 1.46e-29 Primary sclerosing cholangitis; LUSC cis rs9467773 0.620 rs2494692 chr6:26615223 G/A cg05738196 chr6:26577821 NA 0.79 15.3 0.64 1.98e-40 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg18479299 chr3:125709523 NA -0.52 -5.92 -0.31 7.97e-9 Blood pressure (smoking interaction); LUSC cis rs2667011 0.534 rs12692581 chr2:160857482 G/A cg06573604 chr2:160760825 LY75 -0.48 -7.24 -0.37 3.07e-12 Bilirubin levels; LUSC cis rs8016982 0.674 rs759939 chr14:81663453 G/C cg01989461 chr14:81687754 GTF2A1 0.74 13.65 0.6 5.14e-34 Schizophrenia; LUSC cis rs7000551 0.751 rs896379 chr8:22374200 C/T cg12081754 chr8:22256438 SLC39A14 0.45 6.84 0.35 3.73e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs977987 0.806 rs8056236 chr16:75448273 C/T cg03315344 chr16:75512273 CHST6 0.48 8.92 0.44 3.16e-17 Dupuytren's disease; LUSC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg00409905 chr10:38381863 ZNF37A -0.34 -6.0 -0.31 5.21e-9 Extrinsic epigenetic age acceleration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25986360 chr19:41169216 NA -0.43 -6.13 -0.32 2.51e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg09365446 chr1:150670422 GOLPH3L 0.46 6.93 0.35 2.16e-11 Melanoma; LUSC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg03806693 chr22:41940476 POLR3H 0.98 14.16 0.61 5.38e-36 Vitiligo; LUSC cis rs858239 0.541 rs4624924 chr7:23168843 A/C cg23682824 chr7:23144976 KLHL7 0.4 5.76 0.3 1.96e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs12908161 1.000 rs60957376 chr15:85280792 T/G cg12863693 chr15:85201151 NMB 0.41 8.61 0.43 2.99e-16 Schizophrenia; LUSC cis rs9296092 0.560 rs7765263 chr6:33525559 A/G cg13560919 chr6:33536144 NA -0.84 -16.34 -0.67 1.67e-44 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg05425664 chr17:57184151 TRIM37 -0.54 -8.02 -0.4 1.76e-14 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs10883508 chr10:102294413 G/A cg16342193 chr10:102329863 NA -0.37 -6.71 -0.34 8.37e-11 Palmitoleic acid (16:1n-7) levels; LUSC trans rs11098499 1.000 rs11098499 chr4:120187611 C/T cg25214090 chr10:38739885 LOC399744 0.48 7.03 0.36 1.16e-11 Corneal astigmatism; LUSC cis rs76878669 0.561 rs1039594 chr11:66131149 C/T cg24851651 chr11:66362959 CCS -0.36 -5.73 -0.3 2.25e-8 Educational attainment (years of education); LUSC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs11190604 1.000 rs10883499 chr10:102232188 T/A cg07080220 chr10:102295463 HIF1AN 0.64 8.46 0.42 8.63e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9581857 0.725 rs9581853 chr13:28016236 T/C cg22138327 chr13:27999177 GTF3A 0.81 9.21 0.45 3.78e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs3772130 0.962 rs9841595 chr3:121483326 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.13 0.48 3.38e-21 Cognitive performance; LUSC cis rs2041895 0.509 rs10861674 chr12:107304037 A/G cg13944111 chr12:107296891 NA 0.38 6.7 0.34 8.68e-11 Glaucoma (low intraocular pressure); LUSC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21582582 chr3:182698605 DCUN1D1 -0.45 -8.0 -0.4 2.01e-14 Intelligence (multi-trait analysis); LUSC cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.81 0.35 4.44e-11 Rheumatoid arthritis; LUSC cis rs7223966 1.000 rs8074771 chr17:61735865 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.74 0.35 6.99e-11 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs11039798 0.620 rs10838833 chr11:48238880 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.48 0.33 3.28e-10 Axial length; LUSC cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs7561273 0.609 rs3795953 chr2:24345707 C/G cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC cis rs12410462 0.681 rs6682883 chr1:227635598 G/A cg04117972 chr1:227635322 NA 0.82 8.42 0.42 1.11e-15 Major depressive disorder; LUSC cis rs1113500 0.933 rs4590700 chr1:108638344 G/T cg11967332 chr1:108735228 SLC25A24 0.39 5.95 0.31 6.59e-9 Growth-regulated protein alpha levels; LUSC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg00033643 chr7:134001901 SLC35B4 0.43 6.57 0.34 1.97e-10 Mean platelet volume; LUSC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg11742103 chr11:62369870 EML3;MTA2 0.55 8.9 0.44 3.74e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs6430585 0.527 rs62168836 chr2:136463117 G/A cg07169764 chr2:136633963 MCM6 1.06 14.16 0.61 5.57e-36 Corneal structure; LUSC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg08677398 chr8:58056175 NA 0.44 6.05 0.31 3.87e-9 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg10802521 chr3:52805072 NEK4 -0.58 -9.1 -0.45 8.23e-18 Bipolar disorder; LUSC cis rs62400317 0.826 rs11963924 chr6:45306562 C/T cg20913747 chr6:44695427 NA -0.47 -7.72 -0.39 1.35e-13 Total body bone mineral density; LUSC cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg09165964 chr15:75287851 SCAMP5 -0.46 -6.8 -0.35 4.95e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC trans rs62238980 0.614 rs73391051 chr22:32475878 G/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12084011 chr7:107220368 BCAP29 -0.37 -6.01 -0.31 4.74e-9 Electrocardiographic conduction measures; LUSC cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg24692254 chr21:30365293 RNF160 -0.82 -15.21 -0.64 4.55e-40 Dental caries; LUSC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.76 -12.21 -0.56 1.38e-28 Hip circumference adjusted for BMI; LUSC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg11941060 chr3:133502564 NA -0.46 -6.68 -0.34 1.02e-10 Iron status biomarkers; LUSC cis rs9653442 0.545 rs11123814 chr2:100767082 A/G cg07810366 chr2:100720526 AFF3 -0.45 -7.65 -0.39 2.21e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 5.88 0.31 1.02e-8 Mean platelet volume; LUSC cis rs896854 0.573 rs11996455 chr8:95853708 G/A cg09323728 chr8:95962352 TP53INP1 -0.4 -8.28 -0.41 2.91e-15 Type 2 diabetes; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg18765753 chr7:1198926 ZFAND2A -0.36 -6.35 -0.33 7.18e-10 Longevity;Endometriosis; LUSC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 7.86 0.4 5.41e-14 Schizophrenia; LUSC cis rs826838 0.616 rs1601746 chr12:38626195 G/T cg13010199 chr12:38710504 ALG10B -0.48 -7.34 -0.37 1.65e-12 Heart rate; LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.01 0.31 4.91e-9 Menopause (age at onset); LUSC cis rs9462027 0.606 rs2038841 chr6:34738203 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.91 -0.31 8.62e-9 Systemic lupus erythematosus; LUSC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs3806843 1.000 rs12055222 chr5:140165568 T/C cg26395211 chr5:140044315 WDR55 -0.39 -6.0 -0.31 5.16e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs12200560 0.505 rs211174 chr6:97071120 C/T cg06623918 chr6:96969491 KIAA0776 0.49 7.08 0.36 8.76e-12 Coronary heart disease; LUSC cis rs4243830 0.850 rs3761927 chr1:6601773 T/C cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.03 -0.31 4.3e-9 Body mass index; LUSC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg00334542 chr7:100209784 MOSPD3 -0.49 -5.99 -0.31 5.52e-9 Other erythrocyte phenotypes; LUSC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg08048268 chr3:133502702 NA -0.46 -9.04 -0.44 1.26e-17 Iron status biomarkers; LUSC cis rs8060686 0.641 rs9932251 chr16:68131732 G/A cg04539111 chr16:67997858 SLC12A4 -0.42 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.5 -6.99 -0.36 1.5e-11 Renal function-related traits (BUN); LUSC trans rs34421088 0.548 rs2618443 chr8:11384556 A/G cg08975724 chr8:8085496 FLJ10661 -0.48 -7.1 -0.36 7.39e-12 Neuroticism; LUSC cis rs7804356 1.000 rs3801819 chr7:26866698 T/G cg03456212 chr7:26904342 SKAP2 -0.56 -6.44 -0.33 4.07e-10 Type 1 diabetes; LUSC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg00944433 chr1:107599041 PRMT6 0.38 6.96 0.36 1.83e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs887829 0.569 rs7574296 chr2:234638249 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.79 -0.39 8.33e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs9311676 0.609 rs1126551 chr3:58416535 C/T cg13750441 chr3:58318267 PXK 0.35 6.83 0.35 4.14e-11 Systemic lupus erythematosus; LUSC trans rs12310956 0.527 rs1608910 chr12:33895414 T/C cg26384229 chr12:38710491 ALG10B 0.59 9.42 0.46 7.54e-19 Morning vs. evening chronotype; LUSC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg00800038 chr16:89945340 TCF25 -0.75 -6.52 -0.34 2.56e-10 Skin colour saturation; LUSC cis rs861020 0.606 rs629224 chr1:210005071 C/T cg05527609 chr1:210001259 C1orf107 0.67 9.59 0.46 2.08e-19 Orofacial clefts; LUSC cis rs12594515 1.000 rs56412446 chr15:45996424 A/G cg06207120 chr15:45996521 NA 0.39 5.86 0.31 1.11e-8 Waist circumference;Weight; LUSC cis rs9650315 0.570 rs7460090 chr8:57194163 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.48 0.38 6.47e-13 Height; LUSC cis rs7590368 0.774 rs3932106 chr2:10916408 C/T cg15705551 chr2:10952987 PDIA6 0.49 6.46 0.33 3.74e-10 Educational attainment (years of education); LUSC trans rs6582630 0.519 rs11514372 chr12:38308613 T/G cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg07362569 chr17:61921086 SMARCD2 0.35 6.87 0.35 3.13e-11 Prudent dietary pattern; LUSC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg02463440 chr8:22132932 PIWIL2 0.44 7.96 0.4 2.81e-14 Hypertriglyceridemia; LUSC cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.95 14.99 0.63 3.3e-39 Multiple sclerosis; LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg14092988 chr3:52407081 DNAH1 0.31 6.17 0.32 2.03e-9 Bipolar disorder; LUSC cis rs3812762 0.879 rs4929910 chr11:8784869 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.4 7.21 0.37 3.88e-12 Hypospadias; LUSC cis rs3820068 0.705 rs4646075 chr1:15827461 T/C cg17385448 chr1:15911702 AGMAT 0.37 5.86 0.31 1.08e-8 Systolic blood pressure; LUSC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg07716408 chr11:68623521 NA -0.34 -6.68 -0.34 1e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9929218 0.551 rs2274239 chr16:68725783 G/A cg01251360 chr16:68772225 CDH1 -0.27 -6.35 -0.33 7e-10 Colorectal cancer; LUSC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg19468946 chr17:37922297 IKZF3 -0.43 -6.82 -0.35 4.17e-11 Self-reported allergy; LUSC cis rs67311347 0.713 rs9861194 chr3:40309225 C/T cg09455208 chr3:40491958 NA 0.5 9.31 0.45 1.82e-18 Renal cell carcinoma; LUSC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.99 0.31 5.49e-9 Intelligence (multi-trait analysis); LUSC cis rs34172651 0.917 rs7204281 chr16:24784475 C/T cg06028605 chr16:24865363 SLC5A11 0.49 8.58 0.42 3.75e-16 Intelligence (multi-trait analysis); LUSC cis rs7607369 0.648 rs7559629 chr2:219657013 A/T cg02176678 chr2:219576539 TTLL4 -0.66 -12.89 -0.58 4.08e-31 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs765787 0.530 rs1648289 chr15:45516494 A/G cg24006582 chr15:45444508 DUOX1 -0.61 -8.96 -0.44 2.41e-17 Uric acid levels; LUSC cis rs3820928 0.874 rs10182307 chr2:227875360 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.53 -0.38 4.78e-13 Pulmonary function; LUSC cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg24692254 chr21:30365293 RNF160 -0.54 -7.86 -0.4 5.38e-14 Dental caries; LUSC cis rs12908161 1.000 rs12911736 chr15:85240008 A/G cg17507749 chr15:85114479 UBE2QP1 0.56 6.96 0.36 1.8e-11 Schizophrenia; LUSC cis rs78545713 0.536 rs56119218 chr6:26225881 C/A cg23601095 chr6:26197514 HIST1H3D 0.64 5.76 0.3 1.87e-8 Iron status biomarkers (total iron binding capacity); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26505822 chr15:25684203 UBE3A -0.43 -6.49 -0.33 3.14e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs143000161 1 rs143000161 chr2:165710540 A/T cg03182029 chr2:165697222 COBLL1 0.72 6.61 0.34 1.48e-10 Heschl's gyrus morphology; LUSC cis rs6076065 0.723 rs2281429 chr20:23399544 A/T cg11657817 chr20:23433608 CST11 0.42 8.07 0.4 1.28e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs10782582 0.586 rs112368938 chr1:76336339 C/T cg03433033 chr1:76189801 ACADM -0.42 -6.19 -0.32 1.81e-9 Daytime sleep phenotypes; LUSC cis rs7246967 0.611 rs117717959 chr19:22828678 C/T cg23217946 chr19:22817039 ZNF492 0.45 6.04 0.31 4.09e-9 Bronchopulmonary dysplasia; LUSC cis rs7582720 1.000 rs72934518 chr2:203937908 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.69 0.3 2.75e-8 Cerebrospinal P-tau181p levels; LUSC cis rs3768617 0.510 rs1886499 chr1:183095024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg02423579 chr7:2872169 GNA12 -0.46 -6.37 -0.33 6.17e-10 Height; LUSC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.79 0.35 5e-11 Tonsillectomy; LUSC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg20203395 chr5:56204925 C5orf35 -0.79 -10.38 -0.49 4.48e-22 Initial pursuit acceleration; LUSC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg07636037 chr3:49044803 WDR6 0.43 6.26 0.32 1.21e-9 Resting heart rate; LUSC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg08219700 chr8:58056026 NA 0.59 6.95 0.36 1.87e-11 Developmental language disorder (linguistic errors); LUSC cis rs7561273 0.609 rs10189243 chr2:24293756 C/T cg20701182 chr2:24300061 SF3B14 0.45 5.77 0.3 1.76e-8 Quantitative traits; LUSC cis rs17270561 0.609 rs4711101 chr6:25741970 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg00933542 chr6:150070202 PCMT1 0.32 6.76 0.35 6.15e-11 Lung cancer; LUSC cis rs3796619 1.000 rs4974601 chr4:1095410 G/A cg27284194 chr4:1044797 NA 0.5 8.02 0.4 1.75e-14 Recombination rate (males); LUSC trans rs7647973 0.710 rs7629322 chr3:49621994 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -7.4 -0.38 1.15e-12 Menarche (age at onset); LUSC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -18.67 -0.71 8.72e-54 Height; LUSC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg04756594 chr16:24857601 SLC5A11 0.49 7.26 0.37 2.8e-12 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.88 -0.51 8.12e-24 Schizophrenia; LUSC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg23306229 chr2:178417860 TTC30B 0.44 5.72 0.3 2.41e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11190604 1.000 rs2489037 chr10:102319918 A/G cg07080220 chr10:102295463 HIF1AN -0.68 -8.46 -0.42 8.65e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2262909 0.962 rs390730 chr19:22233509 C/A cg11619707 chr19:22235551 ZNF257 -0.38 -5.7 -0.3 2.7e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18492804 chr14:54976994 CGRRF1 0.47 6.44 0.33 4.25e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9341808 0.500 rs806851 chr6:81030831 A/C cg08355045 chr6:80787529 NA -0.41 -7.09 -0.36 7.9e-12 Sitting height ratio; LUSC cis rs8072100 0.967 rs4239162 chr17:45755810 G/A cg25173405 chr17:45401733 C17orf57 -0.38 -6.03 -0.31 4.26e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7000551 0.725 rs2461486 chr8:22392008 T/C cg12081754 chr8:22256438 SLC39A14 0.42 6.2 0.32 1.64e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg20406979 chr6:167373233 NA -0.26 -6.12 -0.32 2.58e-9 Crohn's disease; LUSC cis rs9677476 0.818 rs9973675 chr2:232095484 G/A cg07929768 chr2:232055508 NA 0.35 6.56 0.34 1.99e-10 Food antigen IgG levels; LUSC cis rs713477 0.967 rs1572613 chr14:55909897 C/T cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs6700896 0.864 rs11208691 chr1:66092570 A/G cg04111102 chr1:66153794 NA 0.31 6.87 0.35 3.14e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs877282 0.947 rs7475589 chr10:767479 C/G cg17470449 chr10:769945 NA 0.55 7.68 0.39 1.81e-13 Uric acid levels; LUSC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 14.52 0.62 2.21e-37 Platelet count; LUSC cis rs950881 0.932 rs3771175 chr2:102960210 A/T cg20060108 chr2:102954350 IL1RL1 -0.46 -6.02 -0.31 4.64e-9 Allergy; LUSC cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.92 0.4 3.59e-14 Colorectal cancer; LUSC cis rs17685 1.000 rs17685 chr7:75616105 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -6.14 -0.32 2.39e-9 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 10.12 0.48 3.61e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1178968 0.792 rs1880948 chr7:72722981 G/A cg25889504 chr7:72793014 NA 0.58 7.74 0.39 1.19e-13 Triglyceride levels; LUSC cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.83 -0.51 1.23e-23 Alzheimer's disease (late onset); LUSC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg08280861 chr8:58055591 NA 0.54 5.94 0.31 6.98e-9 Developmental language disorder (linguistic errors); LUSC cis rs72901758 0.669 rs17641275 chr17:76247796 A/C cg25512537 chr17:76250053 NA -0.37 -6.84 -0.35 3.79e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 10.98 0.51 3.81e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12893668 0.667 rs8017628 chr14:104047428 C/T cg04998671 chr14:104000505 TRMT61A -0.45 -6.6 -0.34 1.58e-10 Reticulocyte count; LUSC cis rs1538970 0.669 rs3219476 chr1:45802670 A/C cg15605315 chr1:45957053 TESK2 0.38 5.65 0.3 3.36e-8 Platelet count; LUSC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4474465 0.920 rs10128743 chr11:78214673 C/T cg27205649 chr11:78285834 NARS2 -0.53 -6.0 -0.31 5.03e-9 Alzheimer's disease (survival time); LUSC cis rs6665290 0.904 rs1045285 chr1:227179054 G/A cg10327440 chr1:227177885 CDC42BPA -1.21 -40.25 -0.91 3.51e-130 Myeloid white cell count; LUSC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs7189233 0.550 rs4784312 chr16:53498402 T/C cg09728985 chr16:53543985 NA -0.3 -5.71 -0.3 2.55e-8 Intelligence (multi-trait analysis); LUSC cis rs6599077 1.000 rs6808614 chr3:40097000 T/C cg13683864 chr3:40499215 RPL14 -0.59 -7.56 -0.38 3.95e-13 Sleep-related phenotypes; LUSC cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg22676075 chr6:135203613 NA 0.56 8.8 0.43 7.35e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs478304 0.903 rs12293022 chr11:65531698 C/T cg05805236 chr11:65401703 PCNXL3 0.4 6.79 0.35 5.06e-11 Acne (severe); LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg07092213 chr7:1199455 ZFAND2A -0.54 -8.64 -0.43 2.36e-16 Longevity;Endometriosis; LUSC cis rs3213545 0.659 rs2259693 chr12:121457995 G/A cg02403541 chr12:121454288 C12orf43 0.61 9.51 0.46 3.95e-19 Subjective well-being;Cardiovascular disease risk factors; LUSC cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.87 0.35 3.07e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs72781680 0.898 rs12623316 chr2:24087857 A/G cg20701182 chr2:24300061 SF3B14 0.54 5.73 0.3 2.2e-8 Lymphocyte counts; LUSC cis rs34779708 0.931 rs4934693 chr10:35271844 G/A cg03585969 chr10:35415529 CREM 0.66 9.47 0.46 5.19e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9388451 0.839 rs4897157 chr6:126102981 A/T cg10911889 chr6:126070802 HEY2 0.42 6.39 0.33 5.59e-10 Brugada syndrome; LUSC cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14240646 chr10:27532245 ACBD5 0.6 7.61 0.38 2.85e-13 Breast cancer; LUSC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg04414720 chr1:150670196 GOLPH3L 0.49 7.54 0.38 4.57e-13 Melanoma; LUSC cis rs76878669 0.561 rs7110944 chr11:66118217 C/T cg18002602 chr11:66138449 SLC29A2 -0.48 -8.44 -0.42 9.66e-16 Educational attainment (years of education); LUSC cis rs11792861 0.781 rs72607159 chr9:111764270 C/T cg13535736 chr9:111863775 C9orf5 -0.43 -6.73 -0.35 7.3e-11 Menarche (age at onset); LUSC trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.68 -0.39 1.83e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs4942242 0.626 rs7986998 chr13:44209916 G/A cg19169023 chr15:41853346 TYRO3 0.57 8.75 0.43 1.05e-16 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6542838 0.609 rs13028500 chr2:99528296 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.58 -0.38 3.48e-13 Fear of minor pain; LUSC trans rs72674100 1.000 rs9998866 chr4:97987273 C/A cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg00933542 chr6:150070202 PCMT1 0.32 6.71 0.34 8.26e-11 Lung cancer; LUSC cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg23029597 chr12:123009494 RSRC2 -0.74 -9.58 -0.46 2.27e-19 Body mass index; LUSC trans rs9467711 0.606 rs9379901 chr6:26603866 T/C cg06606381 chr12:133084897 FBRSL1 -0.68 -6.74 -0.35 7.03e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs2736345 0.788 rs2618476 chr8:11352541 A/G cg15556689 chr8:8085844 FLJ10661 0.49 6.75 0.35 6.54e-11 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.74 -0.39 1.18e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs735396 0.770 rs2464196 chr12:121435427 G/A cg25281562 chr12:121454272 C12orf43 0.46 5.86 0.31 1.12e-8 N-glycan levels; LUSC cis rs4363385 0.818 rs1415965 chr1:153002750 G/A cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC cis rs6547741 0.844 rs9941696 chr2:27920064 C/T cg12559939 chr2:27858050 GPN1 -0.4 -6.24 -0.32 1.32e-9 Oral cavity cancer; LUSC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg25019033 chr10:957182 NA -0.51 -6.42 -0.33 4.77e-10 Eosinophil percentage of granulocytes; LUSC cis rs911555 0.504 rs8006526 chr14:104075015 T/C cg24130564 chr14:104152367 KLC1 -0.71 -11.47 -0.53 6.71e-26 Intelligence (multi-trait analysis); LUSC cis rs7264396 0.563 rs7268195 chr20:34339854 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.48 -0.42 7.36e-16 Total cholesterol levels; LUSC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg09796270 chr17:17721594 SREBF1 -0.46 -8.17 -0.41 6.52e-15 Total body bone mineral density; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg14159672 chr1:205819179 PM20D1 -0.85 -15.33 -0.64 1.57e-40 Menarche (age at onset); LUSC cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg07148914 chr20:33460835 GGT7 -0.52 -8.1 -0.41 1.02e-14 Glomerular filtration rate (creatinine); LUSC trans rs56114371 0.777 rs200482 chr6:27773904 G/A cg01620082 chr3:125678407 NA -0.65 -6.72 -0.35 8.04e-11 Breast cancer; LUSC cis rs6546550 0.901 rs10205487 chr2:70151471 C/T cg02498382 chr2:70120550 SNRNP27 0.3 7.28 0.37 2.34e-12 Prevalent atrial fibrillation; LUSC cis rs921968 0.509 rs10932782 chr2:219353195 C/T cg02176678 chr2:219576539 TTLL4 0.73 14.21 0.61 3.48e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg17366294 chr4:99064904 C4orf37 0.58 10.38 0.49 4.47e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg26513180 chr16:89883248 FANCA -0.67 -6.73 -0.35 7.35e-11 Skin colour saturation; LUSC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg00750074 chr16:89608354 SPG7 -0.57 -10.21 -0.49 1.78e-21 Multiple myeloma (IgH translocation); LUSC cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg03709012 chr19:19516395 GATAD2A -0.81 -12.78 -0.57 9.92e-31 Tonsillectomy; LUSC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.44e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg05623727 chr3:50126028 RBM5 -0.35 -6.64 -0.34 1.28e-10 Intelligence (multi-trait analysis); LUSC cis rs10193935 0.901 rs2286702 chr2:42555473 C/T cg27598129 chr2:42591480 NA -0.6 -8.17 -0.41 6.36e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7560272 0.723 rs13386124 chr2:73771695 C/G cg20560298 chr2:73613845 ALMS1 -0.38 -6.08 -0.32 3.29e-9 Schizophrenia; LUSC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg03461704 chr1:205818484 PM20D1 0.39 6.67 0.34 1.08e-10 Menarche (age at onset); LUSC cis rs7084921 0.809 rs11594585 chr10:101811166 C/G cg11888571 chr10:102027403 CWF19L1 -0.41 -5.66 -0.3 3.23e-8 Bone mineral density; LUSC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.69 -0.39 1.63e-13 Personality dimensions; LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg20887711 chr4:1340912 KIAA1530 -0.49 -7.3 -0.37 2.16e-12 Obesity-related traits; LUSC cis rs668210 0.793 rs1204011 chr11:65741086 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.56 -7.08 -0.36 8.6e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs977987 0.778 rs12445726 chr16:75465575 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.4e-11 Dupuytren's disease; LUSC cis rs7584330 0.554 rs74001384 chr2:238424530 T/C cg14458575 chr2:238380390 NA 0.44 5.77 0.3 1.78e-8 Prostate cancer; LUSC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg12927641 chr6:109611667 NA -0.37 -6.38 -0.33 5.82e-10 Reticulocyte fraction of red cells; LUSC trans rs2243480 1.000 rs4548056 chr7:65298873 A/G cg10756647 chr7:56101905 PSPH 0.87 8.4 0.42 1.29e-15 Diabetic kidney disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04250489 chr11:63535821 C11orf95 -0.43 -6.53 -0.34 2.43e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg15549821 chr19:49342101 PLEKHA4 -0.52 -6.09 -0.32 3.13e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs908922 0.676 rs2146120 chr1:152504200 A/T cg20991723 chr1:152506922 NA 0.51 8.99 0.44 1.87e-17 Hair morphology; LUSC trans rs61931739 0.649 rs864614 chr12:33725409 C/A cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg24296786 chr1:45957014 TESK2 0.46 6.76 0.35 6.29e-11 High light scatter reticulocyte count; LUSC cis rs9443189 0.526 rs10943250 chr6:76208445 C/G cg01950844 chr6:76311363 SENP6 0.66 6.71 0.34 8.2e-11 Prostate cancer; LUSC trans rs61931739 0.517 rs11053067 chr12:34191391 T/C cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.46e-16 Morning vs. evening chronotype; LUSC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg24562669 chr7:97807699 LMTK2 0.35 6.19 0.32 1.8e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg04267008 chr7:1944627 MAD1L1 -0.64 -10.33 -0.49 6.91e-22 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.954 rs4345162 chr4:120312959 G/A cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.92 0.31 8.14e-9 Menopause (age at onset); LUSC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg23887609 chr12:130822674 PIWIL1 0.49 7.27 0.37 2.65e-12 Menopause (age at onset); LUSC cis rs2019216 0.521 rs2175657 chr17:21908494 T/G cg22648282 chr17:21454238 C17orf51 -0.52 -7.74 -0.39 1.17e-13 Pelvic organ prolapse; LUSC cis rs34779708 0.966 rs7913615 chr10:35422957 T/G cg03585969 chr10:35415529 CREM 0.58 8.54 0.42 4.68e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg02782426 chr3:40428986 ENTPD3 -0.34 -6.35 -0.33 7.02e-10 Renal cell carcinoma; LUSC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg18876405 chr7:65276391 NA 0.7 12.65 0.57 3.19e-30 Aortic root size; LUSC cis rs4654899 0.802 rs2167811 chr1:21194510 A/G cg01072550 chr1:21505969 NA 0.45 6.61 0.34 1.57e-10 Superior frontal gyrus grey matter volume; LUSC trans rs1486139 1.000 rs1385935 chr7:46266402 A/G cg17534202 chr9:96721102 NA -0.35 -6.15 -0.32 2.26e-9 Select biomarker traits; LUSC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg12639453 chr1:2035780 PRKCZ -0.31 -6.41 -0.33 4.99e-10 Height; LUSC cis rs79839061 0.666 rs62297063 chr4:869708 G/A cg14530993 chr4:882597 GAK 0.72 7.42 0.38 1e-12 Intelligence (multi-trait analysis); LUSC cis rs35000415 0.938 rs17424602 chr7:128687940 A/G cg19972273 chr7:128594194 NA 0.57 5.92 0.31 7.92e-9 Systemic lupus erythematosus; LUSC trans rs2262909 0.962 rs17459246 chr19:22278121 T/C cg17074339 chr11:11642133 GALNTL4 0.44 6.76 0.35 6.13e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs1595825 1.000 rs7582715 chr2:198874310 T/G cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs425277 1.000 rs262676 chr1:2078482 T/A cg03732007 chr1:2071316 PRKCZ 0.47 7.62 0.38 2.68e-13 Height; LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg05347473 chr6:146136440 FBXO30 -0.5 -8.51 -0.42 5.84e-16 Lobe attachment (rater-scored or self-reported); LUSC trans rs62055045 0.528 rs7194638 chr16:71573818 A/G cg15281710 chr15:96890452 NA -0.43 -6.46 -0.33 3.67e-10 Schizophrenia; LUSC cis rs7917772 0.582 rs12782153 chr10:104368294 A/G cg05855489 chr10:104503620 C10orf26 0.49 7.45 0.38 8.2e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11098499 0.818 rs12498599 chr4:120468503 C/T cg09307838 chr4:120376055 NA 0.76 11.04 0.52 2.31e-24 Corneal astigmatism; LUSC cis rs7523273 0.606 rs7144 chr1:207967719 A/G cg22525895 chr1:207977042 MIR29B2 -0.4 -6.52 -0.34 2.59e-10 Schizophrenia; LUSC cis rs9534288 0.913 rs9534299 chr13:46625586 A/T cg15192986 chr13:46630673 CPB2 -0.73 -11.17 -0.52 8.18e-25 Blood protein levels; LUSC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.03e-10 Blood pressure (smoking interaction); LUSC cis rs9457247 0.534 rs9366078 chr6:167399512 A/G cg23791538 chr6:167370224 RNASET2 0.5 8.24 0.41 4.02e-15 Crohn's disease; LUSC cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg24130564 chr14:104152367 KLC1 0.46 6.62 0.34 1.44e-10 Intelligence (multi-trait analysis); LUSC cis rs11250097 0.507 rs2409779 chr8:11311340 A/T cg27411982 chr8:10470053 RP1L1 -0.41 -5.82 -0.3 1.35e-8 Neuroticism; LUSC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -11.86 -0.54 2.61e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs35264875 0.898 rs55648928 chr11:68861591 G/T cg02660097 chr11:68866761 NA 0.43 6.14 0.32 2.36e-9 Blond vs. brown hair color; LUSC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.54e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg01884057 chr2:25150051 NA 0.42 9.13 0.45 6.57e-18 Body mass index; LUSC cis rs8180040 0.764 rs13061071 chr3:47138708 G/A cg27129171 chr3:47204927 SETD2 0.75 13.19 0.59 2.77e-32 Colorectal cancer; LUSC cis rs1577917 0.816 rs12664099 chr6:86648572 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -5.96 -0.31 6.47e-9 Response to antipsychotic treatment; LUSC cis rs427941 0.703 rs201447 chr7:101738384 C/A cg06246474 chr7:101738831 CUX1 0.41 6.71 0.34 8.45e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg18876405 chr7:65276391 NA -0.55 -8.63 -0.43 2.54e-16 Aortic root size; LUSC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg22823121 chr1:150693482 HORMAD1 0.5 7.32 0.37 1.85e-12 Melanoma; LUSC cis rs11158026 0.628 rs8023187 chr14:55381662 T/C cg04306507 chr14:55594613 LGALS3 0.34 6.18 0.32 1.92e-9 Parkinson's disease; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg24503407 chr1:205819492 PM20D1 1.02 23.13 0.78 2.42e-71 Menarche (age at onset); LUSC cis rs5753618 0.561 rs5753521 chr22:31638027 T/C cg22777020 chr22:31556080 RNF185 -0.45 -5.79 -0.3 1.6e-8 Colorectal cancer; LUSC cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg17848003 chr1:3704513 LRRC47 0.31 5.73 0.3 2.2e-8 Red cell distribution width; LUSC cis rs9660992 0.626 rs9326600 chr1:205245268 G/A cg00857998 chr1:205179979 DSTYK 0.52 8.08 0.4 1.17e-14 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4737010 0.511 rs7006871 chr8:41670952 A/G cg08923054 chr8:41654455 ANK1 0.34 6.11 0.32 2.74e-9 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg27537053 chr1:44069790 PTPRF 0.43 6.55 0.34 2.14e-10 Cognitive function;Information processing speed; LUSC cis rs4906332 0.868 rs4900578 chr14:103926010 A/T cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.78e-12 Coronary artery disease; LUSC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11890956 chr21:40555474 PSMG1 1.04 21.0 0.75 5.16e-63 Cognitive function; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg07092213 chr7:1199455 ZFAND2A -0.54 -8.27 -0.41 3.22e-15 Longevity;Endometriosis; LUSC cis rs17270561 0.609 rs4711098 chr6:25734339 C/T cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs9303542 0.694 rs8071207 chr17:46584016 T/C cg09704116 chr17:46666958 LOC404266 0.31 5.95 0.31 6.69e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs7267979 1.000 rs2259837 chr20:25280205 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs909002 0.789 rs3817398 chr1:32119431 C/T cg01639898 chr1:32083012 HCRTR1 -0.32 -7.66 -0.39 2.1e-13 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.560 rs1315354 chr12:38165716 A/G cg26384229 chr12:38710491 ALG10B -0.67 -10.46 -0.5 2.35e-22 Bladder cancer; LUSC cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg24642439 chr20:33292090 TP53INP2 -0.52 -7.78 -0.39 8.86e-14 Glomerular filtration rate (creatinine); LUSC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg15664640 chr17:80829946 TBCD 0.5 8.89 0.44 4e-17 Breast cancer; LUSC cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC cis rs11608355 0.521 rs6606709 chr12:109846714 A/C cg19025524 chr12:109796872 NA -0.4 -7.36 -0.37 1.41e-12 Neuroticism; LUSC trans rs9409565 0.826 rs639276 chr9:97206737 G/T cg05679027 chr9:99775184 HIATL2 -0.49 -7.0 -0.36 1.43e-11 Colorectal cancer (alcohol consumption interaction); LUSC trans rs11165623 0.543 rs6656866 chr1:97002238 T/C cg10631902 chr5:14652156 NA -0.42 -6.21 -0.32 1.55e-9 Hip circumference;Waist circumference; LUSC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.78 -13.68 -0.6 3.77e-34 Total body bone mineral density; LUSC trans rs72674100 1.000 rs4145376 chr4:97994304 C/T cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs6502050 0.871 rs62079998 chr17:80077245 A/C cg07393940 chr7:158741817 NA -0.38 -6.79 -0.35 5.02e-11 Life satisfaction; LUSC cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg22117172 chr7:91764530 CYP51A1 0.32 5.71 0.3 2.49e-8 Breast cancer; LUSC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg11247378 chr22:39784982 NA -0.6 -10.47 -0.5 2.26e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg23791538 chr6:167370224 RNASET2 0.41 6.53 0.34 2.52e-10 Crohn's disease; LUSC cis rs79976124 0.842 rs74881738 chr6:66621825 T/G cg07460842 chr6:66804631 NA 0.7 8.15 0.41 7.18e-15 Type 2 diabetes; LUSC cis rs208520 1.000 rs72884017 chr6:66992513 T/G cg07460842 chr6:66804631 NA 0.93 12.08 0.55 4.03e-28 Exhaled nitric oxide output; LUSC cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC trans rs9929218 0.817 rs3114399 chr16:68713385 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.87 -13.11 -0.58 5.78e-32 Colorectal cancer; LUSC cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg06784218 chr1:46089804 CCDC17 0.53 10.28 0.49 1.01e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg11645453 chr3:52864694 ITIH4 0.32 7.55 0.38 4.18e-13 Intelligence (multi-trait analysis); LUSC cis rs2668423 0.502 rs7254913 chr19:1388320 A/G cg02639931 chr19:1387894 NDUFS7 0.69 15.04 0.64 2.21e-39 Nonalcoholic fatty liver disease; LUSC cis rs7584330 0.554 rs10190935 chr2:238435482 G/A cg14458575 chr2:238380390 NA 0.48 5.97 0.31 6.06e-9 Prostate cancer; LUSC cis rs4808199 0.842 rs11085259 chr19:19445856 C/T cg03709012 chr19:19516395 GATAD2A 0.98 12.03 0.55 6.09e-28 Nonalcoholic fatty liver disease; LUSC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg17252645 chr8:143867129 LY6D 0.38 6.79 0.35 5.28e-11 Urinary tract infection frequency; LUSC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg23172400 chr8:95962367 TP53INP1 0.32 6.4 0.33 5.22e-10 Type 2 diabetes; LUSC cis rs9303401 0.659 rs34382037 chr17:56643550 G/T cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC trans rs877282 0.945 rs71489301 chr10:770191 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.78 -0.35 5.56e-11 Uric acid levels; LUSC cis rs11756438 0.572 rs2638541 chr6:119003743 A/T cg18833306 chr6:118973337 C6orf204 0.37 5.89 0.31 9.22e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs34638657 0.833 rs4889479 chr16:82201474 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.38 -0.33 5.78e-10 Lung adenocarcinoma; LUSC cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg26384229 chr12:38710491 ALG10B 0.86 14.0 0.61 2.4e-35 Bladder cancer; LUSC cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg12011299 chr4:100065546 ADH4 0.72 12.25 0.56 9.7e-29 Alcohol dependence; LUSC cis rs748404 0.697 rs471122 chr15:43558574 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.4 -5.72 -0.3 2.33e-8 Lung cancer; LUSC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg09165964 chr15:75287851 SCAMP5 -0.94 -14.06 -0.61 1.41e-35 Blood trace element (Zn levels); LUSC cis rs4604732 0.642 rs4266925 chr1:247639165 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.36 5.85 0.31 1.15e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9814567 1.000 rs9835204 chr3:134261342 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9303401 0.659 rs12944971 chr17:56988801 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.42 0.56 2.27e-29 Cognitive test performance; LUSC cis rs41271473 0.948 rs12144495 chr1:228810937 G/T cg10167378 chr1:228756711 NA -0.59 -7.22 -0.37 3.55e-12 Chronic lymphocytic leukemia; LUSC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg03684893 chr10:554711 DIP2C -0.37 -6.81 -0.35 4.64e-11 Psychosis in Alzheimer's disease; LUSC cis rs7572644 0.766 rs1506535 chr2:28174081 G/A cg27432699 chr2:27873401 GPN1 0.52 6.45 0.33 3.94e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg00149659 chr3:10157352 C3orf10 1.1 16.32 0.67 1.88e-44 Alzheimer's disease; LUSC cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.32 0.37 1.83e-12 Breast cancer; LUSC cis rs11039100 0.850 rs34161300 chr11:5830740 G/C cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6736093 0.932 rs77096506 chr2:112657554 T/G cg12686935 chr2:112915763 FBLN7 -0.39 -5.99 -0.31 5.37e-9 Coronary artery disease; LUSC cis rs79387448 0.638 rs11465698 chr2:103054577 T/C cg09003973 chr2:102972529 NA 0.98 9.98 0.48 1.08e-20 Gut microbiota (bacterial taxa); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13445258 chr3:128369860 RPN1 0.44 6.58 0.34 1.87e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs11250098 0.526 rs116793410 chr8:10770255 G/T cg15556689 chr8:8085844 FLJ10661 -0.57 -8.06 -0.4 1.37e-14 Morning vs. evening chronotype; LUSC cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg13256891 chr4:100009986 ADH5 0.51 6.97 0.36 1.65e-11 Alcohol dependence; LUSC cis rs7605827 0.930 rs6733647 chr2:15542159 A/G cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg11812906 chr14:75593930 NEK9 -0.41 -6.11 -0.32 2.76e-9 Neuroticism; LUSC cis rs13217239 0.608 rs6930508 chr6:27053142 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -5.9 -0.31 8.86e-9 Schizophrenia; LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg25767906 chr1:53392781 SCP2 -0.52 -9.57 -0.46 2.42e-19 Monocyte count; LUSC cis rs3924048 0.559 rs6541039 chr1:12626261 T/C cg00291366 chr1:12616550 NA 0.32 7.41 0.38 1.03e-12 Optic cup area; LUSC cis rs877282 0.853 rs12779017 chr10:763619 T/C cg17470449 chr10:769945 NA 0.52 7.08 0.36 8.38e-12 Uric acid levels; LUSC cis rs2073300 1.000 rs6132620 chr20:23436654 A/G cg09953122 chr20:23471693 CST8 -0.67 -6.15 -0.32 2.17e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12594515 0.935 rs8042519 chr15:45996341 G/C cg06207120 chr15:45996521 NA 0.39 5.89 0.31 9.36e-9 Waist circumference;Weight; LUSC cis rs7580658 0.817 rs6761447 chr2:128074573 A/T cg09760422 chr2:128146352 NA -0.29 -6.22 -0.32 1.47e-9 Protein C levels; LUSC trans rs7824557 0.564 rs13274106 chr8:11233958 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.86 -0.4 5.4e-14 Retinal vascular caliber; LUSC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg03709012 chr19:19516395 GATAD2A 0.87 14.83 0.63 1.38e-38 Tonsillectomy; LUSC cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.26e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg14004847 chr7:1930337 MAD1L1 -0.49 -7.32 -0.37 1.84e-12 Bipolar disorder and schizophrenia; LUSC cis rs2456568 0.548 rs1607402 chr11:93660732 T/G cg26875233 chr11:93583750 C11orf90 -0.31 -6.05 -0.31 3.91e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs2274273 0.967 rs10147667 chr14:55570849 C/T cg04306507 chr14:55594613 LGALS3 -0.53 -11.86 -0.54 2.47e-27 Protein biomarker; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg13012494 chr21:47604986 C21orf56 -0.54 -8.32 -0.41 2.29e-15 Testicular germ cell tumor; LUSC cis rs4285028 0.948 rs73855481 chr3:121676951 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.63 -0.47 1.55e-19 Multiple sclerosis; LUSC cis rs7586879 0.521 rs1865689 chr2:25108197 C/T cg01884057 chr2:25150051 NA -0.47 -10.78 -0.51 1.9e-23 Body mass index; LUSC cis rs60695258 0.550 rs340648 chr4:87940940 A/G cg10685359 chr4:87814065 C4orf36 0.34 6.1 0.32 2.94e-9 Hematocrit; LUSC cis rs981844 0.689 rs7666762 chr4:154684197 C/T cg14289246 chr4:154710475 SFRP2 -0.52 -7.43 -0.38 9.38e-13 Response to statins (LDL cholesterol change); LUSC cis rs9467773 0.620 rs2130657 chr6:26650826 C/T cg09904177 chr6:26538194 HMGN4 0.66 11.7 0.54 1.01e-26 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg24687639 chr15:41576060 LOC729082 0.51 6.41 0.33 4.82e-10 Cognitive function;Information processing speed; LUSC cis rs513349 1.000 rs513349 chr6:33541719 A/G cg07679836 chr6:33548423 BAK1 0.32 5.71 0.3 2.46e-8 Platelet count; LUSC cis rs4969178 0.965 rs12944051 chr17:76395856 C/T cg05887092 chr17:76393375 PGS1 -0.48 -8.44 -0.42 9.67e-16 HDL cholesterol levels; LUSC cis rs3096299 0.504 rs4785574 chr16:89568875 A/G cg08392591 chr16:89556376 ANKRD11 0.52 8.15 0.41 7.44e-15 Multiple myeloma (IgH translocation); LUSC cis rs9311676 0.609 rs55845662 chr3:58424899 A/C cg26110898 chr3:58419937 PDHB 0.39 6.33 0.33 7.88e-10 Systemic lupus erythematosus; LUSC cis rs62400317 0.826 rs17209769 chr6:45321205 C/A cg18551225 chr6:44695536 NA -0.43 -7.25 -0.37 2.9e-12 Total body bone mineral density; LUSC cis rs4891159 0.548 rs654754 chr18:74143695 T/C cg24786174 chr18:74118243 ZNF516 0.94 20.12 0.74 1.48e-59 Longevity; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg00945038 chr17:61921165 SMARCD2 0.54 9.56 0.46 2.58e-19 Prudent dietary pattern; LUSC cis rs7202877 0.611 rs56092808 chr16:75312716 A/T cg04384234 chr16:75411784 CFDP1 -0.65 -8.79 -0.43 8.13e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9473147 0.843 rs12202615 chr6:47618171 T/C cg12968598 chr6:47444699 CD2AP 0.39 5.89 0.31 9.5e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs2439831 0.867 rs3213990 chr15:43670226 C/A cg02155558 chr15:43621948 ADAL;LCMT2 1.05 12.94 0.58 2.49e-31 Lung cancer in ever smokers; LUSC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg00745463 chr17:30367425 LRRC37B -0.75 -8.66 -0.43 1.98e-16 Hip circumference adjusted for BMI; LUSC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg00677455 chr12:58241039 CTDSP2 0.71 10.71 0.51 3.23e-23 Multiple sclerosis; LUSC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg13175981 chr1:150552382 MCL1 0.46 6.17 0.32 2.02e-9 Blood protein levels; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg01125463 chr6:42946178 PEX6 -0.36 -5.92 -0.31 7.95e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4951018 0.853 rs1573104 chr1:205636907 A/C cg07167872 chr1:205819463 PM20D1 -0.39 -5.83 -0.3 1.33e-8 Prostate-specific antigen levels; LUSC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg04450456 chr4:17643702 FAM184B -0.33 -5.68 -0.3 2.89e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9467773 0.596 rs3001369 chr6:26670969 C/T cg05738196 chr6:26577821 NA 0.77 14.31 0.62 1.51e-36 Intelligence (multi-trait analysis); LUSC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg21782813 chr7:2030301 MAD1L1 0.44 7.38 0.37 1.26e-12 Schizophrenia; LUSC cis rs9788682 0.747 rs2656074 chr15:78741384 T/C cg18825076 chr15:78729989 IREB2 -0.45 -6.1 -0.32 2.87e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg09021430 chr5:549028 NA 0.42 7.47 0.38 7.25e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs9527 0.830 rs11191442 chr10:104643596 T/A cg04362960 chr10:104952993 NT5C2 0.65 9.41 0.46 8.54e-19 Arsenic metabolism; LUSC cis rs1595825 0.891 rs58409972 chr2:198897061 A/T cg10547527 chr2:198650123 BOLL -0.51 -6.06 -0.31 3.69e-9 Ulcerative colitis; LUSC cis rs12210905 1.000 rs115268625 chr6:26948229 C/G cg23155468 chr6:27110703 HIST1H2BK -0.69 -5.96 -0.31 6.57e-9 Hip circumference adjusted for BMI; LUSC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg18681998 chr4:17616180 MED28 0.77 13.73 0.6 2.53e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg25456477 chr12:86230367 RASSF9 0.43 7.69 0.39 1.69e-13 Major depressive disorder; LUSC cis rs7524258 0.868 rs2412153 chr1:7272412 C/T cg07173049 chr1:7289937 CAMTA1 0.34 6.98 0.36 1.55e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg02951883 chr7:2050386 MAD1L1 -0.47 -8.14 -0.41 8.15e-15 Bipolar disorder and schizophrenia; LUSC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg11764359 chr7:65958608 NA 0.61 9.33 0.45 1.46e-18 Calcium levels; LUSC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg00745463 chr17:30367425 LRRC37B -0.79 -9.17 -0.45 4.91e-18 Hip circumference adjusted for BMI; LUSC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.87 0.31 1.06e-8 Rheumatoid arthritis; LUSC cis rs7241530 0.662 rs12454883 chr18:75902642 G/A cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg01884057 chr2:25150051 NA 0.46 10.75 0.51 2.33e-23 Body mass index; LUSC cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg18681998 chr4:17616180 MED28 -0.82 -13.99 -0.61 2.58e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg19901468 chr14:105411992 AHNAK2 -0.71 -12.36 -0.56 3.71e-29 Rheumatoid arthritis; LUSC cis rs11155671 0.530 rs9371223 chr6:150214806 T/C cg07701084 chr6:150067640 NUP43 0.47 6.99 0.36 1.52e-11 Testicular germ cell tumor; LUSC cis rs17286411 0.750 rs12444594 chr16:71941912 A/T cg03805757 chr16:71968109 PKD1L3 0.44 7.16 0.36 5.31e-12 Blood protein levels; LUSC cis rs77972916 0.505 rs6719754 chr2:43526386 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.45 -5.7 -0.3 2.58e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs7000551 0.715 rs2469745 chr8:22343464 C/T cg12081754 chr8:22256438 SLC39A14 0.4 6.13 0.32 2.52e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4363385 0.720 rs1134220 chr1:152976306 T/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.82 -0.39 6.89e-14 Inflammatory skin disease; LUSC cis rs7247513 1.000 rs7247513 chr19:12691185 C/T cg01871581 chr19:12707946 ZNF490 -0.57 -9.0 -0.44 1.79e-17 Bipolar disorder; LUSC cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs6456156 0.774 rs6908364 chr6:167527296 C/T cg07741184 chr6:167504864 NA -0.35 -6.34 -0.33 7.32e-10 Primary biliary cholangitis; LUSC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg23221052 chr5:179740743 GFPT2 -0.65 -10.52 -0.5 1.51e-22 Height; LUSC cis rs28374715 0.662 rs16971558 chr15:41458619 G/A cg18705301 chr15:41695430 NDUFAF1 -0.84 -14.89 -0.63 8.37e-39 Ulcerative colitis; LUSC cis rs9311676 0.632 rs11130642 chr3:58420042 C/T cg26110898 chr3:58419937 PDHB 0.4 6.4 0.33 5.22e-10 Systemic lupus erythematosus; LUSC cis rs8062405 0.965 rs62037363 chr16:28865042 T/C cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg19717773 chr7:2847554 GNA12 -0.37 -6.06 -0.31 3.58e-9 Height; LUSC cis rs963731 0.649 rs10779924 chr2:39208057 G/T cg04010122 chr2:39346883 SOS1 -0.78 -5.7 -0.3 2.71e-8 Corticobasal degeneration; LUSC cis rs9534288 0.830 rs2296641 chr13:46632226 A/C cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC cis rs9300255 0.539 rs1969355 chr12:123742061 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.55 -0.34 2.14e-10 Neutrophil percentage of white cells; LUSC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg06481639 chr22:41940642 POLR3H 0.49 5.72 0.3 2.38e-8 Vitiligo; LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.57 0.38 3.61e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg03538708 chr1:25844672 NA -0.34 -5.83 -0.3 1.3e-8 Erythrocyte sedimentation rate; LUSC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg16339924 chr4:17578868 LAP3 0.61 9.16 0.45 5.45e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.76 -0.35 6.26e-11 Monocyte percentage of white cells; LUSC cis rs3818285 0.556 rs941864 chr10:111656948 T/C cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.93 -0.44 2.9e-17 Superior crus of antihelix expression; LUSC trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg06606381 chr12:133084897 FBRSL1 -0.88 -9.18 -0.45 4.69e-18 Depression; LUSC cis rs17253792 0.822 rs10147431 chr14:56091841 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs7246657 0.943 rs6508732 chr19:38000468 C/T cg23950597 chr19:37808831 NA -0.57 -7.02 -0.36 1.27e-11 Coronary artery calcification; LUSC cis rs6546550 0.835 rs3752781 chr2:70124316 T/A cg02498382 chr2:70120550 SNRNP27 -0.28 -6.82 -0.35 4.39e-11 Prevalent atrial fibrillation; LUSC trans rs7824557 0.510 rs1435274 chr8:11235910 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.6 -0.38 3.04e-13 Retinal vascular caliber; LUSC cis rs7172677 1.000 rs72730601 chr15:75421720 A/T cg14664628 chr15:75095509 CSK 0.46 6.05 0.31 3.83e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11098499 0.954 rs13107475 chr4:120393011 A/T cg24375607 chr4:120327624 NA 0.78 11.59 0.54 2.39e-26 Corneal astigmatism; LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg11965913 chr1:205819406 PM20D1 0.51 7.62 0.38 2.64e-13 Prostate-specific antigen levels; LUSC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg06238570 chr21:40685208 BRWD1 -0.56 -8.91 -0.44 3.33e-17 Menarche (age at onset); LUSC cis rs8102476 0.846 rs11083450 chr19:38754239 T/C cg14131526 chr19:38747285 PPP1R14A -0.32 -5.73 -0.3 2.19e-8 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs7937682 1.000 rs10502147 chr11:111569931 G/A cg19812747 chr11:111475976 SIK2 0.5 6.81 0.35 4.44e-11 Primary sclerosing cholangitis; LUSC cis rs11190604 1.000 rs10883512 chr10:102308516 A/G cg23241863 chr10:102295624 HIF1AN 0.48 5.78 0.3 1.69e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs34638657 0.732 rs7205534 chr16:82201618 C/T cg09439754 chr16:82129088 HSD17B2 -0.38 -6.29 -0.33 1e-9 Lung adenocarcinoma; LUSC cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg00071950 chr4:10020882 SLC2A9 0.65 10.86 0.51 9.66e-24 Bone mineral density; LUSC cis rs10761482 0.500 rs1574466 chr10:62294392 C/T cg18175470 chr10:62150864 ANK3 -0.47 -6.92 -0.35 2.34e-11 Schizophrenia; LUSC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg06238570 chr21:40685208 BRWD1 0.47 7.19 0.37 4.15e-12 Cognitive function; LUSC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.95 0.48 1.38e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2243480 0.901 rs2949697 chr7:65464236 A/G cg10756647 chr7:56101905 PSPH 0.85 8.32 0.41 2.24e-15 Diabetic kidney disease; LUSC cis rs9300255 0.544 rs1716175 chr12:123658388 A/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.14 -0.32 2.4e-9 Neutrophil percentage of white cells; LUSC cis rs7177699 0.534 rs56683682 chr15:79112524 G/T cg15571903 chr15:79123663 NA -0.32 -5.84 -0.3 1.26e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2273669 0.667 rs11752532 chr6:109335969 C/G cg05315195 chr6:109294784 ARMC2 -0.53 -5.89 -0.31 9.28e-9 Prostate cancer; LUSC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg24147428 chr11:65409760 SIPA1 -0.55 -7.76 -0.39 1.08e-13 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs8017423 0.904 rs4603489 chr14:90760607 A/G cg04374321 chr14:90722782 PSMC1 -0.68 -10.28 -0.49 1.03e-21 Mortality in heart failure; LUSC trans rs8072100 1.000 rs4375701 chr17:45712218 C/T cg03886242 chr7:26192032 NFE2L3 -0.38 -6.36 -0.33 6.45e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs629535 0.821 rs680993 chr8:70050247 G/A cg21567404 chr3:27674614 NA 0.96 15.06 0.64 1.7e-39 Dupuytren's disease; LUSC cis rs17401966 1.000 rs1536263 chr1:10378914 T/C cg19773385 chr1:10388646 KIF1B -0.54 -8.39 -0.42 1.41e-15 Hepatocellular carcinoma; LUSC cis rs2742417 0.603 rs2742457 chr3:45767487 G/A cg10512202 chr3:45649293 LIMD1 0.35 5.74 0.3 2.18e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7100689 0.646 rs10749581 chr10:82141651 A/G cg00277334 chr10:82204260 NA 0.5 7.29 0.37 2.21e-12 Post bronchodilator FEV1; LUSC cis rs11048434 0.661 rs34791180 chr12:9110919 T/C cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC cis rs2404618 0.587 rs6994849 chr8:1492839 G/T cg13402656 chr8:1511478 DLGAP2 0.71 11.7 0.54 9.51e-27 Lung cancer; LUSC trans rs2243480 1.000 rs387676 chr7:65598220 C/T cg10756647 chr7:56101905 PSPH 0.87 8.94 0.44 2.62e-17 Diabetic kidney disease; LUSC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg21724239 chr8:58056113 NA 0.59 7.3 0.37 2.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs796364 0.806 rs203769 chr2:200900866 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -8.14 -0.41 7.79e-15 Schizophrenia; LUSC cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg14121845 chr20:25566513 NINL 0.31 5.66 0.3 3.21e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg24110177 chr3:50126178 RBM5 0.57 9.21 0.45 3.63e-18 Intelligence (multi-trait analysis); LUSC cis rs929354 0.739 rs12533082 chr7:157014172 T/A cg17757837 chr7:157058334 UBE3C 0.82 13.3 0.59 1.14e-32 Body mass index; LUSC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg17279839 chr7:150038598 RARRES2 0.48 7.48 0.38 6.65e-13 Blood protein levels;Circulating chemerin levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg25026754 chr15:65426128 PDCD7 -0.5 -6.6 -0.34 1.6e-10 Hepatitis; LUSC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.06 0.31 3.58e-9 Tonsillectomy; LUSC cis rs7568458 0.591 rs55971080 chr2:85812746 T/C cg02493740 chr2:85810744 VAMP5 -0.37 -6.64 -0.34 1.28e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs853679 0.517 rs9380057 chr6:28104634 G/T cg06606381 chr12:133084897 FBRSL1 -0.45 -5.97 -0.31 6.07e-9 Depression; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg09774198 chr13:33160713 PDS5B 0.41 6.6 0.34 1.6e-10 Triglycerides; LUSC cis rs6494488 0.500 rs112691501 chr15:64919260 T/C cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.7e-8 Coronary artery disease; LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.66 -10.96 -0.51 4.44e-24 Prudent dietary pattern; LUSC trans rs1459104 0.714 rs67321261 chr11:54911368 A/G cg15704280 chr7:45808275 SEPT13 0.74 6.28 0.32 1.04e-9 Body mass index; LUSC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg11644478 chr21:40555479 PSMG1 0.95 18.81 0.72 2.45e-54 Cognitive function; LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.9 0.31 9.02e-9 Menopause (age at onset); LUSC cis rs2540226 0.761 rs10206408 chr2:39980482 G/A cg23576258 chr2:39999331 THUMPD2 0.36 6.22 0.32 1.47e-9 Personality dimensions; LUSC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg09796270 chr17:17721594 SREBF1 0.39 6.78 0.35 5.35e-11 Total body bone mineral density; LUSC cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs7186831 1 rs7186831 chr16:75473155 G/A cg03315344 chr16:75512273 CHST6 0.5 9.65 0.47 1.32e-19 Chronic obstructive pulmonary disease; LUSC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg25019033 chr10:957182 NA -0.52 -5.81 -0.3 1.44e-8 Eosinophil percentage of granulocytes; LUSC trans rs208515 0.525 rs12215007 chr6:66671008 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -14.1 -0.61 9.26e-36 Exhaled nitric oxide levels; LUSC cis rs16866061 1.000 rs11681451 chr2:225334104 T/C cg12698349 chr2:225449008 CUL3 0.86 14.03 0.61 1.79e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs12530845 1.000 rs12530845 chr7:135329978 T/C cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs765787 0.530 rs12909987 chr15:45512207 C/T cg25801113 chr15:45476975 SHF 0.3 6.17 0.32 1.95e-9 Uric acid levels; LUSC cis rs5769707 0.605 rs9616702 chr22:50025938 A/G cg10356904 chr22:49881777 NA -0.29 -5.9 -0.31 8.69e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1395 1.000 rs1275538 chr2:27441397 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 7.29 0.37 2.3e-12 Blood metabolite levels; LUSC trans rs8072100 0.967 rs2317826 chr17:45730899 C/T cg03886242 chr7:26192032 NFE2L3 -0.38 -6.37 -0.33 6.31e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03904897 chr3:130612806 ATP2C1 -0.41 -6.12 -0.32 2.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs747782 0.528 rs11039674 chr11:48336116 C/T cg03929089 chr4:120376271 NA 0.66 6.22 0.32 1.47e-9 Intraocular pressure; LUSC cis rs12541635 0.677 rs6469026 chr8:107006356 T/C cg10147462 chr8:107024639 NA 0.66 13.81 0.6 1.21e-34 Age of smoking initiation; LUSC cis rs113835537 0.529 rs2305533 chr11:66298623 A/C cg24851651 chr11:66362959 CCS 0.54 7.86 0.4 5.2e-14 Airway imaging phenotypes; LUSC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs9796 0.727 rs12101934 chr15:41353079 C/T cg18705301 chr15:41695430 NDUFAF1 -0.47 -8.03 -0.4 1.73e-14 Menopause (age at onset); LUSC cis rs12912251 1.000 rs7163869 chr15:38988391 G/C cg01338139 chr15:38987640 C15orf53 -0.5 -6.8 -0.35 4.89e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs7100689 0.646 rs12253992 chr10:82158710 G/A cg01528321 chr10:82214614 TSPAN14 0.84 12.92 0.58 2.91e-31 Post bronchodilator FEV1; LUSC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg11247378 chr22:39784982 NA -0.65 -12.89 -0.58 3.93e-31 Intelligence (multi-trait analysis); LUSC cis rs9517320 1.000 rs7996629 chr13:99128037 C/T cg20487152 chr13:99095054 FARP1 0.35 6.44 0.33 4.08e-10 Longevity; LUSC cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg09537434 chr19:41945824 ATP5SL 0.6 8.64 0.43 2.38e-16 Migraine;Coronary artery disease; LUSC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.57 0.34 1.95e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs6496667 0.642 rs12148876 chr15:91065208 G/A cg03599575 chr15:90893182 GABARAPL3 0.39 5.7 0.3 2.69e-8 Rheumatoid arthritis; LUSC cis rs61931739 0.500 rs11053272 chr12:34547020 C/G cg06521331 chr12:34319734 NA -0.42 -6.56 -0.34 2.08e-10 Morning vs. evening chronotype; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg19318889 chr4:1322082 MAEA 0.44 7.06 0.36 9.44e-12 Obesity-related traits; LUSC cis rs9300255 0.596 rs1568427 chr12:123738678 A/G cg05973401 chr12:123451056 ABCB9 0.51 6.92 0.35 2.27e-11 Neutrophil percentage of white cells; LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03576123 chr11:487126 PTDSS2 -0.89 -9.92 -0.48 1.65e-20 Body mass index; LUSC cis rs7954584 0.616 rs10743185 chr12:122356435 G/A cg01765077 chr12:122356316 WDR66 0.49 6.73 0.35 7.54e-11 Mean corpuscular volume; LUSC cis rs7264396 0.790 rs8125090 chr20:34360015 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.53 -0.42 5.21e-16 Total cholesterol levels; LUSC cis rs1401999 0.650 rs3792585 chr3:183646222 A/G cg05044414 chr3:183734942 ABCC5 0.2 6.88 0.35 3.01e-11 Anterior chamber depth; LUSC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg01283332 chr5:1856932 NA -0.33 -6.34 -0.33 7.28e-10 Cardiovascular disease risk factors; LUSC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs6977660 0.714 rs10224920 chr7:19816173 A/T cg05791153 chr7:19748676 TWISTNB 0.67 7.23 0.37 3.37e-12 Thyroid stimulating hormone; LUSC trans rs4714291 0.963 rs847743 chr6:40087154 C/G cg02267698 chr19:7991119 CTXN1 0.54 7.6 0.38 2.95e-13 Strep throat; LUSC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg26380479 chr7:97908229 NA -0.27 -5.87 -0.31 1.04e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg03213289 chr20:61660250 NA 0.66 12.81 0.57 7.61e-31 Prostate cancer (SNP x SNP interaction); LUSC cis rs9790314 1.000 rs336567 chr3:161073046 A/G cg03342759 chr3:160939853 NMD3 -0.49 -8.14 -0.41 7.81e-15 Morning vs. evening chronotype; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg18765753 chr7:1198926 ZFAND2A -0.45 -7.98 -0.4 2.4e-14 Longevity;Endometriosis; LUSC cis rs9400467 0.528 rs240954 chr6:111659822 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.93 -0.35 2.19e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs3916 1.000 rs3916 chr12:121177272 G/C cg27246729 chr12:121163418 ACADS 0.45 6.53 0.34 2.51e-10 Urinary metabolites (H-NMR features); LUSC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.62 0.47 1.75e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs983392 0.755 rs1441586 chr11:59856028 T/C cg24026212 chr11:59952134 MS4A6A -0.32 -5.68 -0.3 2.97e-8 Alzheimer's disease (late onset); LUSC cis rs7917772 0.582 rs10786695 chr10:104368756 A/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.0 -0.31 5.11e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9473147 0.516 rs9349415 chr6:47551861 T/C cg12968598 chr6:47444699 CD2AP 0.52 7.93 0.4 3.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs12900413 0.562 rs28557101 chr15:90298149 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.9 -0.31 8.68e-9 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs61931739 0.534 rs11052959 chr12:33997095 T/C cg13010199 chr12:38710504 ALG10B 0.56 8.27 0.41 3.18e-15 Morning vs. evening chronotype; LUSC cis rs9815354 0.812 rs4299460 chr3:41952445 A/C cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg27494647 chr7:150038898 RARRES2 0.51 7.83 0.39 6.69e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs3087591 0.960 rs4795587 chr17:29587917 A/C cg24425628 chr17:29625626 OMG;NF1 -0.64 -9.2 -0.45 4.12e-18 Hip circumference; LUSC trans rs7618501 0.633 rs6446189 chr3:50008566 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 9.02 0.44 1.52e-17 Intelligence (multi-trait analysis); LUSC cis rs7572644 0.662 rs13402420 chr2:28271435 T/G cg27432699 chr2:27873401 GPN1 -0.52 -7.03 -0.36 1.2e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg21535247 chr6:8435926 SLC35B3 0.58 9.01 0.44 1.59e-17 Motion sickness; LUSC cis rs739496 0.542 rs7316698 chr12:111790511 C/T cg10833066 chr12:111807467 FAM109A 0.61 11.92 0.55 1.55e-27 Platelet count; LUSC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg05855489 chr10:104503620 C10orf26 -0.64 -9.51 -0.46 3.8e-19 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12579753 0.879 rs1987116 chr12:82156478 G/A cg07988820 chr12:82153109 PPFIA2 -0.45 -6.67 -0.34 1.04e-10 Resting heart rate; LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg00166722 chr3:10149974 C3orf24 -0.6 -8.48 -0.42 7.15e-16 Alzheimer's disease; LUSC cis rs2219968 0.828 rs4739190 chr8:78928417 A/G cg00738934 chr8:78996279 NA -0.41 -7.24 -0.37 3.06e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9747201 1.000 rs4347682 chr17:80175591 A/G cg18209359 chr17:80159595 CCDC57 -0.36 -5.82 -0.3 1.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg18876405 chr7:65276391 NA -0.56 -8.67 -0.43 1.96e-16 Aortic root size; LUSC cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.58 -0.46 2.27e-19 Body mass index; LUSC cis rs72802342 0.541 rs185052 chr16:75467063 C/T cg03315344 chr16:75512273 CHST6 -0.45 -6.5 -0.34 2.94e-10 Advanced age-related macular degeneration; LUSC cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.74 7.4 0.38 1.14e-12 Initial pursuit acceleration; LUSC cis rs6696846 0.630 rs11240373 chr1:205135600 A/C cg00857998 chr1:205179979 DSTYK 0.68 10.21 0.49 1.83e-21 Red blood cell count; LUSC cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.45 6.1 0.32 2.92e-9 Multiple sclerosis; LUSC cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.72 -0.43 1.32e-16 Axial length; LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg20887711 chr4:1340912 KIAA1530 -0.65 -10.07 -0.48 5.38e-21 Obesity-related traits; LUSC cis rs1577917 1.000 rs6936048 chr6:86702608 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.7 -0.43 1.51e-16 Response to antipsychotic treatment; LUSC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 14.13 0.61 7.23e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1372520 0.532 rs2583972 chr4:90747411 T/G cg01966878 chr4:90757139 SNCA -0.42 -6.03 -0.31 4.37e-9 Neuroticism; LUSC cis rs73198271 0.515 rs1589613 chr8:8626940 T/C cg01851573 chr8:8652454 MFHAS1 0.62 7.34 0.37 1.61e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3806843 0.576 rs246007 chr5:140338748 C/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2652834 0.851 rs2652819 chr15:63431175 A/G cg05507819 chr15:63340323 TPM1 0.47 6.04 0.31 4.08e-9 HDL cholesterol; LUSC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg25643088 chr3:52874325 TMEM110 0.4 6.01 0.31 4.9e-9 Schizophrenia; LUSC cis rs807669 0.934 rs1780643 chr22:19191725 T/C cg02655711 chr22:19163373 SLC25A1 0.9 17.43 0.69 7.75e-49 Metabolite levels; LUSC trans rs11098499 0.779 rs10016060 chr4:120298412 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg08847533 chr14:75593920 NEK9 -0.79 -13.69 -0.6 3.7e-34 Height; LUSC cis rs911555 0.723 rs4906324 chr14:103923099 A/G cg24130564 chr14:104152367 KLC1 0.45 6.51 0.34 2.72e-10 Intelligence (multi-trait analysis); LUSC cis rs2281845 0.507 rs12025414 chr1:201100496 A/G cg22815214 chr1:201083145 CACNA1S 0.43 5.9 0.31 8.71e-9 Permanent tooth development; LUSC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg11764359 chr7:65958608 NA 0.51 6.6 0.34 1.58e-10 Aortic root size; LUSC cis rs9875589 0.509 rs1873005 chr3:14060223 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.18 0.37 4.69e-12 Ovarian reserve; LUSC cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg17892150 chr10:133769511 PPP2R2D -0.68 -9.46 -0.46 5.56e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09877593 chr5:10564514 ANKRD33B -0.41 -6.5 -0.34 2.86e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs68170813 0.559 rs7804979 chr7:106999453 C/G cg02696742 chr7:106810147 HBP1 -0.61 -9.29 -0.45 2.08e-18 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15709087 chr19:33793161 CEBPA;LOC80054 0.44 6.15 0.32 2.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7605827 0.538 rs62120660 chr2:15659613 T/C cg19274914 chr2:15703543 NA 0.47 9.19 0.45 4.24e-18 Educational attainment (years of education); LUSC cis rs8017423 0.935 rs716122 chr14:90792313 A/C cg14092571 chr14:90743983 NA 0.36 5.9 0.31 8.78e-9 Mortality in heart failure; LUSC trans rs11088226 0.681 rs2409456 chr21:33929374 G/A cg09050820 chr6:167586206 TCP10L2 0.74 9.73 0.47 7.17e-20 Gastritis; LUSC cis rs138918 0.771 rs138934 chr22:43566924 A/C cg08909806 chr22:43548696 TSPO 0.34 5.89 0.31 9.29e-9 Monocyte count; LUSC cis rs3815700 1.000 rs3815700 chr19:33093252 T/C cg02997394 chr19:33096574 ANKRD27 0.79 8.95 0.44 2.44e-17 Eosinophilic esophagitis; LUSC cis rs2274273 0.967 rs11622740 chr14:55617844 G/A cg04306507 chr14:55594613 LGALS3 0.54 11.95 0.55 1.23e-27 Protein biomarker; LUSC trans rs7613875 0.641 rs2624845 chr3:50062437 C/A cg21659725 chr3:3221576 CRBN -0.52 -8.34 -0.42 2.04e-15 Body mass index; LUSC cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg20203395 chr5:56204925 C5orf35 -0.52 -7.62 -0.38 2.7e-13 Coronary artery disease; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg18000306 chr6:288505 NA 0.33 6.23 0.32 1.43e-9 Menopause (age at onset); LUSC cis rs2273669 0.667 rs12196024 chr6:109302258 C/T cg05315195 chr6:109294784 ARMC2 -0.53 -5.94 -0.31 7.15e-9 Prostate cancer; LUSC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg03188948 chr7:1209495 NA 0.46 6.18 0.32 1.87e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9394152 0.845 rs7747216 chr6:33476718 A/G cg13560919 chr6:33536144 NA -0.59 -10.93 -0.51 5.64e-24 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs208520 1.000 rs72882102 chr6:66983408 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC trans rs6480314 0.542 rs61854804 chr10:70015576 C/T cg04882175 chr6:131122610 NA -0.55 -6.22 -0.32 1.49e-9 Optic nerve measurement (disc area); LUSC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg18252515 chr7:66147081 NA 1.2 13.69 0.6 3.51e-34 Diabetic kidney disease; LUSC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg18404041 chr3:52824283 ITIH1 0.44 7.84 0.39 6.21e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg25767906 chr1:53392781 SCP2 -0.34 -5.66 -0.3 3.33e-8 Monocyte count; LUSC cis rs6426558 0.537 rs4653813 chr1:227461510 G/C cg10327440 chr1:227177885 CDC42BPA 0.55 7.41 0.38 1.05e-12 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.26 0.52 3.74e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs2262909 0.962 rs73021832 chr19:22316144 G/C cg17074339 chr11:11642133 GALNTL4 0.43 6.62 0.34 1.42e-10 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02513392 chr12:112601463 C12orf51 -0.72 -6.46 -0.33 3.73e-10 Cognitive performance; LUSC cis rs72634258 0.945 rs225131 chr1:8095486 T/C cg00042356 chr1:8021962 PARK7 0.61 7.65 0.39 2.19e-13 Inflammatory bowel disease; LUSC cis rs12681287 0.547 rs56752411 chr8:87515156 C/T cg00550725 chr8:87521180 FAM82B 0.44 5.75 0.3 2.07e-8 Caudate activity during reward; LUSC cis rs137699 0.652 rs2413589 chr22:39755689 C/T cg11247378 chr22:39784982 NA 0.41 6.24 0.32 1.36e-9 IgG glycosylation; LUSC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg21643547 chr1:205240462 TMCC2 -0.5 -9.3 -0.45 1.95e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg16423285 chr20:60520624 NA -0.47 -5.82 -0.3 1.38e-8 Body mass index; LUSC cis rs9300255 0.602 rs2510885 chr12:123614813 G/C cg00376283 chr12:123451042 ABCB9 0.68 8.74 0.43 1.12e-16 Neutrophil percentage of white cells; LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg14004847 chr7:1930337 MAD1L1 -0.54 -8.2 -0.41 5.29e-15 Bipolar disorder and schizophrenia; LUSC cis rs4595586 0.545 rs12816546 chr12:39398913 C/T cg13010199 chr12:38710504 ALG10B 0.41 6.03 0.31 4.33e-9 Morning vs. evening chronotype; LUSC trans rs2243480 1.000 rs451396 chr7:65484074 T/A cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.59e-15 Diabetic kidney disease; LUSC cis rs72634258 0.503 rs707457 chr1:7831064 C/A cg26816564 chr1:7831052 VAMP3 1.08 14.73 0.63 3.37e-38 Inflammatory bowel disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25129346 chr5:68665436 TAF9;RAD17 -0.44 -6.77 -0.35 5.92e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7572644 0.699 rs7602328 chr2:28235184 G/A cg27432699 chr2:27873401 GPN1 -0.52 -7.02 -0.36 1.28e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18312812 chr19:2900898 ZNF57 -0.45 -6.62 -0.34 1.43e-10 Hepatitis; LUSC cis rs4664308 1.000 rs17341301 chr2:160902420 G/A cg03641300 chr2:160917029 PLA2R1 -0.64 -10.71 -0.51 3.35e-23 Idiopathic membranous nephropathy; LUSC cis rs12421382 0.616 rs2357795 chr11:109381135 C/T cg27471124 chr11:109292789 C11orf87 0.42 7.35 0.37 1.56e-12 Schizophrenia; LUSC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2974760 0.606 rs6600143 chr16:201389 A/C cg08400316 chr16:204221 HBZ -0.82 -13.04 -0.58 1.06e-31 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs7939886 0.920 rs74699881 chr11:55913852 A/T cg15704280 chr7:45808275 SEPT13 0.8 6.49 0.33 3.19e-10 Myopia (pathological); LUSC trans rs7737355 1.000 rs7737355 chr5:130604811 T/A cg07715041 chr7:99302981 CYP3A7 -0.38 -6.1 -0.32 3.01e-9 Life satisfaction; LUSC cis rs6577655 0.517 rs2241893 chr8:135586659 C/T cg17885191 chr8:135476712 NA 0.6 7.76 0.39 1.06e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs8078723 0.738 rs4065321 chr17:38143548 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.46 7.52 0.38 5.02e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.58e-16 Developmental language disorder (linguistic errors); LUSC trans rs656319 0.625 rs4526366 chr8:9890179 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.42 -0.38 9.66e-13 Myopia (pathological); LUSC cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg11266682 chr4:10021025 SLC2A9 -0.51 -9.37 -0.46 1.15e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7592578 0.640 rs56127319 chr2:191296429 G/A cg10560079 chr2:191398806 TMEM194B -0.65 -8.06 -0.4 1.41e-14 Diastolic blood pressure; LUSC cis rs3820928 1.000 rs4675120 chr2:227774888 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.8e-14 Pulmonary function; LUSC cis rs6967385 0.560 rs2192833 chr7:12355303 A/T cg20607287 chr7:12443886 VWDE 0.45 6.8 0.35 4.88e-11 Response to taxane treatment (placlitaxel); LUSC cis rs7589342 0.745 rs933793 chr2:106511846 C/T cg16077055 chr2:106428750 NCK2 -0.35 -6.61 -0.34 1.48e-10 Addiction; LUSC cis rs7223966 1.000 rs56383601 chr17:61929968 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.45 0.33 3.89e-10 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs61931739 0.929 rs10844740 chr12:34067930 C/T cg13010199 chr12:38710504 ALG10B -0.46 -7.4 -0.38 1.14e-12 Morning vs. evening chronotype; LUSC cis rs17685 0.753 rs13240967 chr7:75658197 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.52 7.99 0.4 2.24e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs8060686 0.641 rs12448677 chr16:68209741 G/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs709400 0.663 rs17679475 chr14:103916958 A/G cg12935359 chr14:103987150 CKB -0.58 -9.0 -0.44 1.69e-17 Body mass index; LUSC cis rs1448094 0.802 rs7487591 chr12:86434112 T/C cg00310523 chr12:86230176 RASSF9 0.36 6.47 0.33 3.4e-10 Major depressive disorder; LUSC cis rs782590 0.967 rs58003472 chr2:55797507 T/C cg03859395 chr2:55845619 SMEK2 0.87 16.02 0.66 2.98e-43 Metabolic syndrome; LUSC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg05535760 chr7:792225 HEATR2 0.81 9.46 0.46 5.75e-19 Cerebrospinal P-tau181p levels; LUSC cis rs6500395 1.000 rs9930365 chr16:48682154 A/C cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.69e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs4332037 0.586 rs62442944 chr7:2015047 T/G cg25206134 chr2:45395956 NA 0.6 7.06 0.36 9.76e-12 Bipolar disorder; LUSC cis rs6722750 0.716 rs6546058 chr2:64421702 A/G cg22352474 chr2:64371530 PELI1 -0.54 -7.98 -0.4 2.31e-14 Neuroticism; LUSC cis rs983392 0.805 rs11230184 chr11:59965789 G/A cg20284999 chr11:59952153 MS4A6A -0.39 -6.37 -0.33 6.25e-10 Alzheimer's disease (late onset); LUSC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC cis rs2204008 0.837 rs2127955 chr12:37969194 A/G cg13010199 chr12:38710504 ALG10B 0.6 9.42 0.46 7.95e-19 Bladder cancer; LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg03188948 chr7:1209495 NA 0.68 7.14 0.36 5.96e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.42 0.33 4.65e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7712401 0.720 rs12109791 chr5:122146831 C/T cg19077854 chr5:122220652 SNX24 0.35 8.03 0.4 1.72e-14 Mean platelet volume; LUSC trans rs9291683 0.935 rs1860911 chr4:10275057 C/T cg26043149 chr18:55253948 FECH 0.49 7.65 0.39 2.23e-13 Bone mineral density; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg26338869 chr17:61819248 STRADA -0.41 -6.02 -0.31 4.66e-9 Prudent dietary pattern; LUSC cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs807669 0.504 rs8141941 chr22:19166263 G/A cg02655711 chr22:19163373 SLC25A1 0.57 10.42 0.5 3.35e-22 Metabolite levels; LUSC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg14784868 chr12:69753453 YEATS4 0.67 9.97 0.48 1.16e-20 Cerebrospinal fluid biomarker levels; LUSC cis rs10493773 0.609 rs3753789 chr1:86174814 T/C cg17807903 chr1:86174739 ZNHIT6 -0.54 -14.59 -0.62 1.18e-37 Urate levels in overweight individuals; LUSC trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg15704280 chr7:45808275 SEPT13 -0.91 -13.24 -0.59 1.93e-32 Coronary artery disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg19995800 chr19:45873596 ERCC2 0.44 5.99 0.31 5.54e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg11764359 chr7:65958608 NA -0.78 -12.94 -0.58 2.53e-31 Aortic root size; LUSC cis rs10791323 0.517 rs1120247 chr11:133745180 T/G cg00579200 chr11:133705235 NA -0.39 -5.7 -0.3 2.58e-8 Childhood ear infection; LUSC trans rs1908814 0.516 rs11996277 chr8:11800031 G/A cg15556689 chr8:8085844 FLJ10661 0.57 8.71 0.43 1.39e-16 Neuroticism; LUSC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg26597838 chr10:835615 NA 0.97 13.23 0.59 2.1e-32 Eosinophil percentage of granulocytes; LUSC cis rs8040855 0.599 rs4577058 chr15:85726458 T/C cg04831495 chr15:85060580 GOLGA6L5 0.41 6.82 0.35 4.25e-11 Bulimia nervosa; LUSC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg04369109 chr6:150039330 LATS1 -0.57 -8.39 -0.42 1.37e-15 Lung cancer; LUSC cis rs7824557 0.564 rs7834572 chr8:11236685 C/T cg21775007 chr8:11205619 TDH -0.65 -10.26 -0.49 1.22e-21 Retinal vascular caliber; LUSC cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg11266682 chr4:10021025 SLC2A9 0.47 8.43 0.42 1.06e-15 Bone mineral density; LUSC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg10664184 chr19:17420304 DDA1 0.47 6.16 0.32 2.04e-9 Systemic lupus erythematosus; LUSC cis rs11864453 0.514 rs2269918 chr16:72134831 C/A cg16558253 chr16:72132732 DHX38 -0.37 -5.92 -0.31 8.15e-9 Fibrinogen levels; LUSC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.43 -6.59 -0.34 1.75e-10 Alzheimer's disease (late onset); LUSC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg20307385 chr11:47447363 PSMC3 0.43 5.78 0.3 1.72e-8 Subjective well-being; LUSC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg08859206 chr1:53392774 SCP2 -0.42 -6.86 -0.35 3.29e-11 Monocyte count; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04260258 chr11:65386128 PCNXL3 -0.38 -5.96 -0.31 6.41e-9 Asthma; LUSC cis rs8044868 0.541 rs7202268 chr16:72086746 A/G cg16579770 chr16:72058938 DHODH 0.34 5.73 0.3 2.26e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.12 0.36 6.82e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg26380479 chr7:97908229 NA -0.28 -6.08 -0.32 3.21e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7267979 0.727 rs2474765 chr20:25245950 G/T cg08601574 chr20:25228251 PYGB 0.38 5.81 0.3 1.48e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8016982 0.634 rs1035948 chr14:81682392 C/T cg01989461 chr14:81687754 GTF2A1 0.73 13.22 0.59 2.28e-32 Schizophrenia; LUSC cis rs13223928 0.592 rs4722439 chr7:3155858 C/T cg19214707 chr7:3157722 NA 0.43 8.85 0.44 5.38e-17 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.18 -0.52 7.38e-25 Mean corpuscular volume; LUSC cis rs225245 0.791 rs7406966 chr17:34013636 A/C cg05299278 chr17:33885742 SLFN14 0.3 6.49 0.33 3.01e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.73 0.39 1.29e-13 Major depressive disorder; LUSC cis rs5758265 1 rs5758265 chr22:41617897 G/A cg03806693 chr22:41940476 POLR3H -0.5 -6.94 -0.36 2e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg00990874 chr7:1149470 C7orf50 0.62 8.28 0.41 2.96e-15 Bronchopulmonary dysplasia; LUSC trans rs7833787 0.759 rs4921964 chr8:18679795 A/C cg25885280 chr11:70760166 SHANK2 0.26 6.45 0.33 3.9e-10 Obesity-related traits; LUSC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.05 -0.31 3.94e-9 Crohn's disease; LUSC cis rs184065563 1 rs184065563 chr6:45144224 G/A cg18551225 chr6:44695536 NA -0.42 -6.96 -0.36 1.84e-11 Total body bone mineral density (age over 60);Total body bone mineral density; LUSC cis rs1348850 0.574 rs11889488 chr2:178426793 A/G cg27490568 chr2:178487706 NA -0.47 -6.77 -0.35 5.63e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.73 0.47 7.14e-20 Bipolar disorder; LUSC trans rs1493916 0.905 rs7239283 chr18:31395397 G/A cg13755796 chr4:20253514 NA -0.42 -6.61 -0.34 1.55e-10 Life satisfaction; LUSC cis rs4595586 0.545 rs6580895 chr12:39372011 C/T cg26384229 chr12:38710491 ALG10B -0.48 -6.85 -0.35 3.48e-11 Morning vs. evening chronotype; LUSC cis rs8180040 0.593 rs10433549 chr3:47031433 C/T cg02527881 chr3:46936655 PTH1R 0.41 7.02 0.36 1.22e-11 Colorectal cancer; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg27094323 chr7:1216898 NA -0.47 -8.42 -0.42 1.11e-15 Longevity;Endometriosis; LUSC trans rs7937682 0.889 rs542424 chr11:111477698 T/C cg18187862 chr3:45730750 SACM1L 0.52 6.84 0.35 3.74e-11 Primary sclerosing cholangitis; LUSC cis rs9393777 0.720 rs35212793 chr6:26998693 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.54 -6.36 -0.33 6.81e-10 Intelligence (multi-trait analysis); LUSC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg22496380 chr5:211416 CCDC127 -0.73 -8.34 -0.41 2.03e-15 Breast cancer; LUSC cis rs4964805 0.526 rs934845 chr12:104185257 T/G cg02344784 chr12:104178138 NT5DC3 0.45 8.7 0.43 1.56e-16 Attention deficit hyperactivity disorder; LUSC cis rs9814567 1.000 rs6766818 chr3:134226159 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.75 -0.6 2.03e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg08807101 chr21:30365312 RNF160 -0.67 -10.46 -0.5 2.35e-22 Pancreatic cancer; LUSC cis rs7815909 0.609 rs6474057 chr8:57209655 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.64 7.79 0.39 8.63e-14 Height; LUSC cis rs11166629 0.502 rs2467030 chr8:135665361 A/G cg27224718 chr8:135614730 ZFAT 0.49 7.38 0.37 1.28e-12 Smoking quantity; LUSC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg15448220 chr1:150897856 SETDB1 0.41 6.18 0.32 1.84e-9 Melanoma; LUSC cis rs225245 0.791 rs6505492 chr17:34026597 C/T cg05299278 chr17:33885742 SLFN14 0.3 6.55 0.34 2.14e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg10523679 chr1:76189770 ACADM -0.78 -10.7 -0.51 3.54e-23 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -6.78 -0.35 5.61e-11 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg19077165 chr18:44547161 KATNAL2 -0.4 -6.06 -0.31 3.63e-9 Personality dimensions; LUSC cis rs4786125 0.665 rs1873704 chr16:6907021 C/G cg03623568 chr16:6915990 A2BP1 -0.5 -8.02 -0.4 1.8e-14 Heart rate variability traits (SDNN); LUSC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg02423579 chr7:2872169 GNA12 -0.43 -5.96 -0.31 6.52e-9 Height; LUSC cis rs11229555 0.645 rs7929028 chr11:58188258 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg03433033 chr1:76189801 ACADM -0.45 -6.81 -0.35 4.64e-11 Daytime sleep phenotypes; LUSC trans rs4811340 0.562 rs4809911 chr20:51178696 G/T cg15736553 chr3:11610338 VGLL4 -0.33 -5.95 -0.31 6.7e-9 Thyroid peroxidase antibody positivity; LUSC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg14440974 chr22:39074834 NA -0.38 -6.37 -0.33 6.21e-10 Menopause (age at onset); LUSC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg13531842 chr10:38383804 ZNF37A -0.45 -7.08 -0.36 8.53e-12 Extrinsic epigenetic age acceleration; LUSC cis rs11209185 0.509 rs2419044 chr1:68421087 C/T cg22082780 chr1:68452167 NA 0.42 6.62 0.34 1.45e-10 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs3733585 0.631 rs4697707 chr4:10119787 G/T cg00071950 chr4:10020882 SLC2A9 -0.54 -8.63 -0.43 2.48e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs6942756 1.000 rs2402945 chr7:128956256 C/A cg02491457 chr7:128862824 NA -0.47 -6.31 -0.33 9.1e-10 White matter hyperintensity burden; LUSC cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg25208724 chr1:156163844 SLC25A44 1.03 17.97 0.7 5.47e-51 Testicular germ cell tumor; LUSC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg16434002 chr17:42200994 HDAC5 -0.46 -6.43 -0.33 4.32e-10 Total body bone mineral density; LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC cis rs7147624 0.573 rs10148699 chr14:66199662 G/A cg03016385 chr14:66212404 NA -0.78 -8.29 -0.41 2.79e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4589502 1.000 rs75502100 chr15:67131417 T/C cg12317470 chr15:67143691 NA 0.67 6.02 0.31 4.6e-9 Lung cancer (smoking interaction); LUSC trans rs2204008 0.805 rs3863360 chr12:37966432 C/T cg06521331 chr12:34319734 NA -0.42 -6.53 -0.34 2.39e-10 Bladder cancer; LUSC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg24829409 chr8:58192753 C8orf71 -0.64 -7.74 -0.39 1.17e-13 Developmental language disorder (linguistic errors); LUSC trans rs629535 0.911 rs490165 chr8:70014976 A/G cg21567404 chr3:27674614 NA -0.95 -15.49 -0.65 3.59e-41 Dupuytren's disease; LUSC cis rs73206853 0.764 rs73191812 chr12:110910279 G/A cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg09359103 chr1:154839909 KCNN3 -0.71 -16.53 -0.67 2.9e-45 Prostate cancer; LUSC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs11971779 0.590 rs4732374 chr7:139091453 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs4363385 0.818 rs684305 chr1:153006242 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs7577696 0.606 rs212747 chr2:32414704 A/G cg02381751 chr2:32503542 YIPF4 0.54 7.16 0.36 5.15e-12 Inflammatory biomarkers; LUSC cis rs11676348 0.755 rs13410318 chr2:219022910 T/G cg00012203 chr2:219082015 ARPC2 0.58 9.7 0.47 9.04e-20 Ulcerative colitis; LUSC cis rs7712401 0.601 rs30047 chr5:122270524 G/A cg19077854 chr5:122220652 SNX24 0.41 8.94 0.44 2.64e-17 Mean platelet volume; LUSC cis rs6964587 0.967 rs17164315 chr7:91659150 C/G cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.71e-18 Breast cancer; LUSC cis rs9309473 1.000 rs7582606 chr2:73813945 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.49 -0.33 3.18e-10 Metabolite levels; LUSC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg04282206 chr17:62833786 PLEKHM1P 0.41 6.06 0.31 3.6e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8017423 0.967 rs7158180 chr14:90729117 C/T cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg02580895 chr19:2754563 NA -0.47 -7.1 -0.36 7.55e-12 Total cholesterol levels; LUSC trans rs2243480 0.901 rs1701759 chr7:65470932 G/T cg10756647 chr7:56101905 PSPH 0.85 8.29 0.41 2.87e-15 Diabetic kidney disease; LUSC cis rs5771069 0.897 rs137858 chr22:50445601 T/C cg27467552 chr22:50353597 PIM3 -0.41 -7.08 -0.36 8.64e-12 Ulcerative colitis; LUSC cis rs11190604 1.000 rs10883505 chr10:102280772 C/T cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.26e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6580649 0.831 rs1635528 chr12:48395900 C/T cg05342945 chr12:48394962 COL2A1 -0.43 -5.69 -0.3 2.73e-8 Lung cancer; LUSC cis rs1348850 0.540 rs10172355 chr2:178443225 A/G cg27490568 chr2:178487706 NA 0.38 5.77 0.3 1.84e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2737618 0.674 rs2821332 chr1:200085714 A/T cg21825944 chr1:200113062 NR5A2 -0.31 -5.92 -0.31 8.19e-9 Uric acid levels; LUSC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg12463550 chr7:65579703 CRCP 0.47 6.96 0.36 1.86e-11 Aortic root size; LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.34 0.59 7.64e-33 Platelet count; LUSC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg22903471 chr2:27725779 GCKR -0.42 -7.22 -0.37 3.59e-12 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05238905 chr6:149867353 PPIL4 -0.5 -7.51 -0.38 5.41e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs644799 0.710 rs10765771 chr11:95521044 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.87 13.76 0.6 1.96e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7582180 0.614 rs4851309 chr2:100975390 C/T cg12002119 chr2:101014098 CHST10 0.35 5.67 0.3 3.13e-8 Intelligence (multi-trait analysis); LUSC cis rs950881 0.932 rs13431828 chr2:102954653 C/T cg20060108 chr2:102954350 IL1RL1 0.45 5.9 0.31 8.86e-9 Allergy; LUSC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 6.86 0.35 3.43e-11 Multiple sclerosis; LUSC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg25456477 chr12:86230367 RASSF9 0.4 7.08 0.36 8.54e-12 Major depressive disorder; LUSC cis rs367943 1.000 rs168366 chr5:112818587 C/T cg12552261 chr5:112820674 MCC 0.44 7.07 0.36 8.94e-12 Type 2 diabetes; LUSC trans rs1864729 0.688 rs1476132 chr8:98305993 A/G cg08679828 chr8:102218111 ZNF706 -0.8 -6.54 -0.34 2.37e-10 Estradiol plasma levels (breast cancer); LUSC cis rs243505 0.528 rs6977453 chr7:148474746 A/G cg09806900 chr7:148480153 CUL1 0.65 9.75 0.47 6.21e-20 Inflammatory bowel disease;Crohn's disease; LUSC trans rs7129220 0.858 rs7930218 chr11:10234712 G/T cg06252276 chr11:34852392 NA -0.55 -5.96 -0.31 6.49e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs950169 0.881 rs4842852 chr15:84941961 A/G cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs12421382 0.659 rs56410856 chr11:109382455 T/G cg11473876 chr11:109292803 C11orf87 0.41 6.58 0.34 1.78e-10 Schizophrenia; LUSC trans rs61931739 0.500 rs1843736 chr12:34012080 C/G cg13010199 chr12:38710504 ALG10B 0.55 8.27 0.41 3.16e-15 Morning vs. evening chronotype; LUSC trans rs890100 0.867 rs1978530 chr2:56743753 A/G cg08299783 chr2:48920986 GTF2A1L;LHCGR 0.32 6.28 0.32 1.04e-9 Gut microbiome composition (summer); LUSC cis rs7799006 0.606 rs34262822 chr7:2304275 C/T cg08027265 chr7:2291960 NA -0.62 -11.03 -0.52 2.55e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.49e-8 Breast cancer; LUSC cis rs9650657 0.645 rs4841409 chr8:10516374 C/T cg27411982 chr8:10470053 RP1L1 0.49 7.8 0.39 8.18e-14 Neuroticism; LUSC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.77 0.3 1.8e-8 Lung cancer; LUSC cis rs7923609 0.905 rs10740129 chr10:65250808 G/A cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.07e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg00814883 chr7:100076585 TSC22D4 -0.75 -10.25 -0.49 1.27e-21 Platelet count; LUSC cis rs10464366 0.843 rs4723819 chr7:39111241 C/T cg18850127 chr7:39170497 POU6F2 0.41 5.98 0.31 5.62e-9 IgG glycosylation; LUSC cis rs1864400 0.641 rs61845681 chr10:43733180 T/C cg15436174 chr10:43711423 RASGEF1A 0.41 6.26 0.32 1.15e-9 Hirschsprung disease; LUSC trans rs1218582 0.772 rs6699043 chr1:154913021 T/C cg05839875 chr5:39203190 FYB -0.32 -6.03 -0.31 4.39e-9 Prostate cancer; LUSC cis rs9527 0.590 rs7088200 chr10:104793235 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.57 0.46 2.39e-19 Arsenic metabolism; LUSC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg06582575 chr6:163149167 PACRG;PARK2 1.12 15.13 0.64 9.18e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg16325326 chr1:53192061 ZYG11B -0.82 -14.16 -0.61 5.52e-36 Monocyte count; LUSC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.5 -6.84 -0.35 3.88e-11 Mean platelet volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08039701 chr5:74063125 NSA2;GFM2 -0.49 -6.36 -0.33 6.5e-10 Bipolar disorder and schizophrenia; LUSC cis rs10779751 0.690 rs910661 chr1:11130116 C/A cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg11645453 chr3:52864694 ITIH4 0.35 7.97 0.4 2.5e-14 Bipolar disorder; LUSC cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg18964960 chr10:1102726 WDR37 -0.45 -6.13 -0.32 2.54e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs2692947 0.727 rs1657502 chr2:96795608 A/C cg23100626 chr2:96804247 ASTL 0.26 6.57 0.34 1.94e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs10191773 0.535 rs12477879 chr2:112969865 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.63 -7.79 -0.39 8.31e-14 Yeast infection; LUSC cis rs11971779 0.680 rs2355785 chr7:139070983 C/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg13683864 chr3:40499215 RPL14 -1.01 -16.92 -0.68 7.96e-47 Renal cell carcinoma; LUSC cis rs7789940 0.951 rs73140055 chr7:75975777 A/T cg10167463 chr7:75959203 YWHAG -0.65 -9.74 -0.47 6.73e-20 Multiple sclerosis; LUSC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.18 -0.32 1.82e-9 Total body bone mineral density; LUSC trans rs7618501 0.633 rs2883057 chr3:49998282 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.58 9.26 0.45 2.47e-18 Intelligence (multi-trait analysis); LUSC cis rs17428076 0.556 rs12692976 chr2:172684403 G/T cg13550731 chr2:172543902 DYNC1I2 -0.38 -5.81 -0.3 1.47e-8 Myopia; LUSC trans rs4332037 1.000 rs10240470 chr7:1949971 G/T cg25206134 chr2:45395956 NA -0.54 -6.29 -0.33 9.78e-10 Bipolar disorder; LUSC cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.61 0.65 1.27e-41 Bladder cancer; LUSC cis rs6076065 0.748 rs999068 chr20:23376483 G/A cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg06212747 chr3:49208901 KLHDC8B 0.43 5.83 0.3 1.33e-8 Parkinson's disease; LUSC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg27165867 chr14:105738592 BRF1 -0.5 -7.35 -0.37 1.57e-12 Mean platelet volume;Platelet distribution width; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25946216 chr14:74253857 C14orf43 -0.4 -6.11 -0.32 2.73e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg03188948 chr7:1209495 NA 0.61 7.25 0.37 2.85e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs1325195 0.920 rs2816210 chr1:179193932 C/T cg11624085 chr17:8464688 MYH10 0.44 6.97 0.36 1.7e-11 IgE grass sensitization; LUSC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs9807989 0.507 rs1592458 chr2:103031749 A/T cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC cis rs7829975 0.774 rs35431455 chr8:8673736 T/C cg08975724 chr8:8085496 FLJ10661 0.53 7.7 0.39 1.51e-13 Mood instability; LUSC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg06219351 chr7:158114137 PTPRN2 0.49 8.86 0.44 4.81e-17 Calcium levels; LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg25036284 chr2:26402008 FAM59B 0.66 9.82 0.47 3.63e-20 Gut microbiome composition (summer); LUSC cis rs208520 0.690 rs6929762 chr6:66709277 C/T cg07460842 chr6:66804631 NA 1.09 17.17 0.68 8.31e-48 Exhaled nitric oxide output; LUSC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg22535103 chr8:58192502 C8orf71 -0.79 -8.06 -0.4 1.36e-14 Developmental language disorder (linguistic errors); LUSC cis rs35146811 0.695 rs858508 chr7:99821381 C/G cg13334819 chr7:99746414 C7orf59 0.49 6.5 0.34 2.96e-10 Coronary artery disease; LUSC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg14552801 chr7:65878734 NA 0.45 6.34 0.33 7.34e-10 Aortic root size; LUSC cis rs2901656 0.875 rs7516301 chr1:172372260 T/C cg03748243 chr1:172413542 C1orf105;PIGC 0.29 5.65 0.3 3.43e-8 Red cell distribution width;Platelet distribution width; LUSC cis rs11098499 0.908 rs2017057 chr4:120257711 A/G cg24375607 chr4:120327624 NA 0.78 11.69 0.54 1.1e-26 Corneal astigmatism; LUSC cis rs804280 0.509 rs35626932 chr8:11786932 C/A cg00405596 chr8:11794950 NA 0.35 5.76 0.3 1.88e-8 Myopia (pathological); LUSC cis rs3770081 1.000 rs2303339 chr2:86346180 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 1.05 7.18 0.37 4.42e-12 Facial emotion recognition (sad faces); LUSC cis rs4423214 1.000 rs12422045 chr11:71154820 C/T cg05163923 chr11:71159392 DHCR7 0.71 11.0 0.52 3.1e-24 Vitamin D levels; LUSC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg18357526 chr6:26021779 HIST1H4A 0.44 6.95 0.36 1.98e-11 Intelligence (multi-trait analysis); LUSC cis rs9616064 0.531 rs66909472 chr22:47050210 G/A cg05621596 chr22:47072043 GRAMD4 -0.54 -8.62 -0.43 2.75e-16 Urate levels in obese individuals; LUSC trans rs1941687 0.831 rs1353168 chr18:31359762 A/G cg27147174 chr7:100797783 AP1S1 -0.48 -7.03 -0.36 1.14e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs17685 0.753 rs6464999 chr7:75787315 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs7618501 0.633 rs4688755 chr3:50064424 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -9.5 -0.46 4.34e-19 Intelligence (multi-trait analysis); LUSC cis rs17001868 0.892 rs73167023 chr22:40799954 T/C cg07138101 chr22:40742427 ADSL 0.55 5.69 0.3 2.81e-8 Mammographic density (dense area); LUSC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg15448220 chr1:150897856 SETDB1 0.43 6.22 0.32 1.45e-9 Melanoma; LUSC cis rs4499344 0.526 rs8100915 chr19:33032310 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.8 -10.68 -0.5 4.31e-23 Mean platelet volume; LUSC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.81 0.75 2.88e-62 Cognitive ability; LUSC cis rs11209002 0.614 rs7519768 chr1:67555522 C/T cg02640540 chr1:67518911 SLC35D1 0.65 9.21 0.45 3.77e-18 Crohn's disease; LUSC cis rs9815354 1.000 rs6768563 chr3:41865541 G/A cg03022575 chr3:42003672 ULK4 0.59 6.57 0.34 1.97e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs12681287 0.752 rs4288357 chr8:87251833 C/T cg27223183 chr8:87520930 FAM82B -0.45 -5.76 -0.3 1.87e-8 Caudate activity during reward; LUSC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg03209412 chr4:183728196 NA 0.46 7.05 0.36 1.04e-11 Pediatric autoimmune diseases; LUSC cis rs11122272 0.637 rs2808593 chr1:231524228 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC cis rs2359239 0.519 rs8007145 chr14:75185748 T/A cg08847533 chr14:75593920 NEK9 0.48 6.92 0.35 2.36e-11 Neuroticism (multi-trait analysis); LUSC cis rs7572644 0.766 rs13021285 chr2:28085347 T/C cg27432699 chr2:27873401 GPN1 0.51 6.42 0.33 4.57e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9513627 1.000 rs73556172 chr13:100121684 A/G cg25919922 chr13:100150906 NA -0.8 -6.96 -0.36 1.83e-11 Obesity-related traits; LUSC cis rs3744061 0.520 rs9908979 chr17:74645486 T/G cg27546012 chr17:74684504 MXRA7 -0.38 -6.69 -0.34 9.45e-11 Retinal arteriolar caliber; LUSC cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg24642439 chr20:33292090 TP53INP2 0.71 11.51 0.53 4.99e-26 Coronary artery disease; LUSC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg18351406 chr4:77819688 ANKRD56 0.59 8.57 0.42 3.99e-16 Emphysema distribution in smoking; LUSC cis rs1385374 0.858 rs11059927 chr12:129294333 T/C cg09035930 chr12:129282057 SLC15A4 -0.64 -6.8 -0.35 4.96e-11 Systemic lupus erythematosus; LUSC cis rs394563 0.602 rs409099 chr6:149766863 T/G cg11245181 chr6:149772854 ZC3H12D -0.3 -6.57 -0.34 1.95e-10 Dupuytren's disease; LUSC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg06112835 chr11:68658793 MRPL21 0.48 7.51 0.38 5.32e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 10.84 0.51 1.13e-23 Prudent dietary pattern; LUSC cis rs4363385 0.747 rs4240867 chr1:152954921 A/G cg00922841 chr1:152955080 SPRR1A 0.44 7.89 0.4 4.36e-14 Inflammatory skin disease; LUSC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7824557 0.734 rs2293856 chr8:11177447 C/T cg21293242 chr8:11204541 TDH 0.34 6.4 0.33 5.32e-10 Retinal vascular caliber; LUSC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg18904891 chr8:8559673 CLDN23 0.55 7.56 0.38 3.95e-13 Obesity-related traits; LUSC cis rs6688613 0.729 rs10918603 chr1:166936503 T/C cg07049167 chr1:166818506 POGK 0.43 5.77 0.3 1.79e-8 Refractive astigmatism; LUSC cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg26384229 chr12:38710491 ALG10B 0.95 18.32 0.71 2.18e-52 Heart rate; LUSC cis rs977987 0.843 rs6564259 chr16:75447393 T/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.62 -0.34 1.4e-10 Dupuytren's disease; LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg18538332 chr22:24372958 LOC391322 -0.4 -7.36 -0.37 1.45e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg03929089 chr4:120376271 NA -1.04 -19.98 -0.74 5.38e-59 Height; LUSC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg06740227 chr12:86229804 RASSF9 -0.44 -7.09 -0.36 7.89e-12 Major depressive disorder; LUSC cis rs2204008 0.714 rs11520135 chr12:38114863 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.89 0.66 9.43e-43 Bladder cancer; LUSC cis rs6121246 0.697 rs6060912 chr20:30325755 C/A cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -9.91 -0.48 1.88e-20 Chronic sinus infection; LUSC trans rs11696501 0.739 rs4812933 chr20:44230792 C/A cg03272292 chr12:48577362 C12orf68 0.52 6.1 0.32 2.87e-9 Brain structure; LUSC cis rs12118280 0.581 rs545593 chr1:108720242 G/A cg11967332 chr1:108735228 SLC25A24 -0.52 -6.79 -0.35 5.06e-11 Myeloid white cell count; LUSC cis rs709400 0.832 rs55864158 chr14:104068579 G/A cg24130564 chr14:104152367 KLC1 -0.5 -7.18 -0.37 4.49e-12 Body mass index; LUSC cis rs1580019 0.922 rs34545272 chr7:32460630 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.81 12.17 0.55 1.9e-28 Cognitive ability; LUSC cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg24130564 chr14:104152367 KLC1 -0.42 -6.15 -0.32 2.2e-9 Body mass index; LUSC cis rs7246967 0.551 rs16998998 chr19:22911116 T/C cg23217946 chr19:22817039 ZNF492 0.46 6.22 0.32 1.48e-9 Bronchopulmonary dysplasia; LUSC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg21028142 chr17:79581711 NPLOC4 0.33 7.76 0.39 1.03e-13 Eye color traits; LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs9660992 0.649 rs12128229 chr1:205268014 C/A cg00857998 chr1:205179979 DSTYK 0.6 9.06 0.44 1.11e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4268898 0.760 rs11676939 chr2:24479057 C/T cg06627628 chr2:24431161 ITSN2 0.59 8.49 0.42 6.83e-16 Asthma; LUSC cis rs17014483 0.749 rs2924348 chr4:89632910 A/G cg01026744 chr4:89619053 NAP1L5;HERC3 0.68 5.97 0.31 5.92e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7246967 0.673 rs4933017 chr19:22812980 T/C cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs3772130 1.000 rs2070180 chr3:121351338 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.66 -9.56 -0.46 2.77e-19 Cognitive performance; LUSC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.97 20.13 0.74 1.38e-59 Subjective well-being; LUSC cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg17420585 chr12:42539391 GXYLT1 -0.38 -7.25 -0.37 2.94e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2282802 0.685 rs62385161 chr5:139635747 T/C cg26211634 chr5:139558579 C5orf32 0.44 8.3 0.41 2.59e-15 Intelligence (multi-trait analysis); LUSC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.67 10.62 0.5 7.03e-23 Body mass index (adult); LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg26314531 chr2:26401878 FAM59B -0.73 -10.21 -0.49 1.79e-21 Gut microbiome composition (summer); LUSC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs427941 0.632 rs201475 chr7:101745883 G/T cg06246474 chr7:101738831 CUX1 0.39 6.42 0.33 4.68e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs41271473 1.000 rs41270189 chr1:228878888 C/T cg10167378 chr1:228756711 NA 0.54 6.59 0.34 1.72e-10 Chronic lymphocytic leukemia; LUSC cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg05347473 chr6:146136440 FBXO30 0.6 10.6 0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg24642439 chr20:33292090 TP53INP2 -0.52 -8.1 -0.41 1.03e-14 Glomerular filtration rate (creatinine); LUSC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.96 0.31 6.45e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg20135002 chr11:47629003 NA -0.46 -7.53 -0.38 4.77e-13 Subjective well-being; LUSC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg04478727 chr12:58166393 METTL1;FAM119B -0.44 -6.15 -0.32 2.24e-9 Multiple sclerosis; LUSC trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -8.05 -0.4 1.52e-14 Retinal vascular caliber; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg05025164 chr4:1340916 KIAA1530 0.42 6.43 0.33 4.51e-10 Obesity-related traits; LUSC cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg06784218 chr1:46089804 CCDC17 0.54 10.91 0.51 6.6e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg02038168 chr22:39784481 NA -0.48 -7.81 -0.39 7.41e-14 Intelligence (multi-trait analysis); LUSC cis rs2463822 0.507 rs72919442 chr11:62028707 A/G cg06239285 chr11:62104954 ASRGL1 -0.57 -5.81 -0.3 1.49e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7223966 1.000 rs11658175 chr17:61923838 G/A cg00945038 chr17:61921165 SMARCD2 0.38 5.74 0.3 2.14e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg08847533 chr14:75593920 NEK9 -0.82 -15.11 -0.64 1.17e-39 Height; LUSC cis rs6577655 0.517 rs2315835 chr8:135589854 A/G cg17885191 chr8:135476712 NA 0.59 7.8 0.39 8.22e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg20203395 chr5:56204925 C5orf35 -0.6 -8.29 -0.41 2.7e-15 Initial pursuit acceleration; LUSC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg13395646 chr4:1353034 KIAA1530 -0.8 -13.59 -0.6 8.35e-34 Obesity-related traits; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg04234412 chr22:24373322 LOC391322 -0.87 -15.46 -0.65 4.84e-41 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12361290 chr11:129149358 NA -0.52 -6.55 -0.34 2.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs12421382 0.659 rs56410856 chr11:109382455 T/G cg16359550 chr11:109292809 C11orf87 0.37 6.37 0.33 6.29e-10 Schizophrenia; LUSC cis rs2857891 0.817 rs2857901 chr11:6980511 A/G cg14883916 chr11:6947541 ZNF215 0.45 5.83 0.3 1.29e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.71 -0.57 1.82e-30 Alzheimer's disease; LUSC cis rs9341808 1.000 rs9341808 chr6:80953257 C/A cg08355045 chr6:80787529 NA 0.51 8.94 0.44 2.7e-17 Sitting height ratio; LUSC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg05347473 chr6:146136440 FBXO30 0.47 7.61 0.38 2.88e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg17507749 chr15:85114479 UBE2QP1 0.68 8.55 0.42 4.36e-16 Schizophrenia; LUSC cis rs713477 0.631 rs7145182 chr14:55905231 C/G cg13175173 chr14:55914753 NA -0.29 -5.9 -0.31 8.84e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs4268898 0.662 rs9917355 chr2:24433400 C/T cg06627628 chr2:24431161 ITSN2 -0.89 -13.28 -0.59 1.29e-32 Asthma; LUSC cis rs921968 0.541 rs55996799 chr2:219558193 C/G cg02176678 chr2:219576539 TTLL4 -0.74 -14.3 -0.62 1.62e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs6545883 0.825 rs7578139 chr2:61564121 G/A cg15711740 chr2:61764176 XPO1 0.42 6.54 0.34 2.32e-10 Tuberculosis; LUSC cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg03522245 chr20:25566470 NINL 0.36 5.84 0.3 1.24e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7903847 0.642 rs10882915 chr10:99142184 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.28 -0.37 2.45e-12 Granulocyte percentage of myeloid white cells; LUSC trans rs8002861 0.641 rs2028813 chr13:44422126 G/T cg12856521 chr11:46389249 DGKZ 0.47 6.77 0.35 5.74e-11 Leprosy; LUSC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC trans rs28647808 0.786 rs4962135 chr9:136256630 C/T cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs7267979 1.000 rs2258563 chr20:25273435 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.03 0.74 3.56e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1908814 0.516 rs4840597 chr8:11796068 A/C cg27411982 chr8:10470053 RP1L1 0.39 6.04 0.31 4.05e-9 Neuroticism; LUSC cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg22875332 chr1:76189707 ACADM -0.43 -6.54 -0.34 2.31e-10 Daytime sleep phenotypes; LUSC cis rs3820928 0.874 rs10178731 chr2:227874232 C/T cg11843606 chr2:227700838 RHBDD1 -0.51 -7.26 -0.37 2.67e-12 Pulmonary function; LUSC cis rs4073582 0.595 rs555360 chr11:65960061 T/C cg14036092 chr11:66035641 RAB1B -0.41 -5.86 -0.31 1.12e-8 Gout; LUSC trans rs4689592 0.546 rs10937784 chr4:7060935 G/C cg07817883 chr1:32538562 TMEM39B -0.59 -7.32 -0.37 1.81e-12 Monocyte percentage of white cells; LUSC cis rs11098499 0.820 rs13128602 chr4:120459366 C/T cg24375607 chr4:120327624 NA -0.74 -11.04 -0.52 2.27e-24 Corneal astigmatism; LUSC cis rs73195822 0.527 rs55728229 chr12:111169374 T/A cg12870014 chr12:110450643 ANKRD13A 0.66 7.25 0.37 2.98e-12 Itch intensity from mosquito bite; LUSC cis rs78545713 0.502 rs57145038 chr6:26311510 A/C cg13736514 chr6:26305472 NA -0.45 -5.9 -0.31 8.98e-9 Iron status biomarkers (total iron binding capacity); LUSC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg21856205 chr7:94953877 PON1 -0.36 -5.72 -0.3 2.33e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg04733989 chr22:42467013 NAGA 0.56 8.64 0.43 2.4e-16 Schizophrenia; LUSC cis rs11822910 0.737 rs2584858 chr11:57207077 C/T cg00522883 chr11:57194120 SLC43A3 0.39 6.26 0.32 1.18e-9 Platelet distribution width; LUSC trans rs561341 0.941 rs8066558 chr17:30272879 G/T cg20587970 chr11:113659929 NA -1.12 -15.37 -0.64 1.06e-40 Hip circumference adjusted for BMI; LUSC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg06618935 chr21:46677482 NA -0.4 -8.13 -0.41 8.35e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7599312 0.553 rs6710653 chr2:213404893 A/G cg16329650 chr2:213403929 ERBB4 0.86 18.45 0.71 6.91e-53 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4901869 0.902 rs2162491 chr14:59296247 C/T cg02291164 chr14:59296302 NA 0.58 11.49 0.53 5.43e-26 Panic disorder; LUSC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg09365446 chr1:150670422 GOLPH3L 0.47 6.82 0.35 4.25e-11 Melanoma; LUSC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs3820928 0.605 rs4281898 chr2:227855493 A/C cg11843606 chr2:227700838 RHBDD1 -0.59 -9.15 -0.45 5.96e-18 Pulmonary function; LUSC cis rs11105298 0.891 rs6538189 chr12:89885923 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.04e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg05313129 chr8:58192883 C8orf71 -0.51 -5.7 -0.3 2.65e-8 Developmental language disorder (linguistic errors); LUSC cis rs7568458 0.870 rs1972297 chr2:85808573 T/C cg02493740 chr2:85810744 VAMP5 -0.33 -5.86 -0.31 1.08e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg23758822 chr17:41437982 NA 1.04 19.54 0.73 3.11e-57 Menopause (age at onset); LUSC cis rs2235649 0.704 rs1742425 chr16:1904524 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.46 -5.68 -0.3 2.98e-8 Blood metabolite levels; LUSC trans rs8072100 0.790 rs34200664 chr17:45744652 C/T cg03886242 chr7:26192032 NFE2L3 0.41 6.53 0.34 2.5e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg08085267 chr17:45401833 C17orf57 -0.44 -6.45 -0.33 3.95e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.68 0.34 9.71e-11 Menopause (age at onset); LUSC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg09165964 chr15:75287851 SCAMP5 -1.01 -15.29 -0.64 2.16e-40 Blood trace element (Zn levels); LUSC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.28e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19518452 chr22:21336528 LZTR1 -0.42 -6.08 -0.32 3.23e-9 Electrocardiographic conduction measures; LUSC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg05623727 chr3:50126028 RBM5 0.34 6.39 0.33 5.71e-10 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg11366901 chr6:160182831 ACAT2 0.97 13.24 0.59 1.84e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs11098499 0.955 rs1511018 chr4:120161580 G/T cg24375607 chr4:120327624 NA 0.77 11.62 0.54 1.97e-26 Corneal astigmatism; LUSC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg17264618 chr3:40429014 ENTPD3 0.3 6.12 0.32 2.65e-9 Renal cell carcinoma; LUSC cis rs7572644 0.639 rs17006242 chr2:28001051 A/C cg27432699 chr2:27873401 GPN1 -0.53 -6.95 -0.36 1.92e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7100689 0.577 rs10749560 chr10:82092801 G/T cg01528321 chr10:82214614 TSPAN14 0.82 12.42 0.56 2.14e-29 Post bronchodilator FEV1; LUSC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg25039879 chr17:56429692 SUPT4H1 -0.65 -8.87 -0.44 4.54e-17 Cognitive test performance; LUSC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg00677455 chr12:58241039 CTDSP2 0.59 7.92 0.4 3.64e-14 Multiple sclerosis; LUSC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.45 -0.33 3.88e-10 Lung cancer; LUSC cis rs11098499 0.866 rs12510451 chr4:120289143 C/T cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs6684514 0.845 rs12138564 chr1:156291600 G/T cg16558208 chr1:156270281 VHLL 0.36 5.76 0.3 1.9e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs2282802 0.685 rs2337082 chr5:139649201 G/A cg26211634 chr5:139558579 C5orf32 0.44 8.14 0.41 7.78e-15 Intelligence (multi-trait analysis); LUSC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg06108461 chr20:60628389 TAF4 -1.0 -17.66 -0.69 9.05e-50 Body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26018965 chr1:183604789 ARPC5;RGL1 -0.49 -6.55 -0.34 2.24e-10 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.863 rs2306457 chr4:120472839 T/A cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC trans rs8072100 0.935 rs8070759 chr17:45638760 C/T cg04995722 chr7:26192034 NFE2L3 0.38 6.2 0.32 1.67e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs35484700 1 rs35484700 chr4:55498781 CG/C cg18836493 chr4:55524333 KIT -0.34 -5.68 -0.3 2.94e-8 White blood cell count; LUSC cis rs7223966 1.000 rs6504168 chr17:61697469 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.68 0.34 1.01e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1008375 1.000 rs10939743 chr4:17662731 G/A cg16339924 chr4:17578868 LAP3 0.54 8.0 0.4 2.03e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.16e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs10435719 0.902 rs7014580 chr8:11803262 C/G cg08975724 chr8:8085496 FLJ10661 0.47 6.87 0.35 3.09e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2857891 0.862 rs957747 chr11:6966814 A/G cg14883916 chr11:6947541 ZNF215 0.46 5.88 0.31 9.84e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg00531865 chr16:30841666 NA -0.33 -5.92 -0.31 7.91e-9 Dementia with Lewy bodies; LUSC cis rs11785400 0.793 rs4371985 chr8:143737279 C/T cg10596483 chr8:143751796 JRK 0.51 7.5 0.38 5.74e-13 Schizophrenia; LUSC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.37 -6.06 -0.31 3.76e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg20573242 chr4:122745356 CCNA2 0.66 10.54 0.5 1.26e-22 Type 2 diabetes; LUSC cis rs7089973 0.604 rs7904188 chr10:116610271 G/C cg25233709 chr10:116636983 FAM160B1 0.37 6.56 0.34 2.09e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21240523 chr9:130965902 CIZ1;DNM1 0.45 6.82 0.35 4.3e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6424115 0.679 rs2267961 chr1:24071048 A/G cg10978503 chr1:24200527 CNR2 -0.47 -9.36 -0.46 1.22e-18 Immature fraction of reticulocytes; LUSC cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.76 8.88 0.44 4.19e-17 Schizophrenia; LUSC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg06453172 chr10:134556979 INPP5A -0.49 -6.11 -0.32 2.78e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs3126085 0.935 rs4845423 chr1:152184950 T/G cg26876637 chr1:152193138 HRNR 0.44 6.4 0.33 5.27e-10 Atopic dermatitis; LUSC cis rs1941023 0.503 rs10792269 chr11:60117126 C/T cg08716584 chr11:60157161 MS4A7 -0.59 -11.27 -0.52 3.41e-25 Congenital heart disease (maternal effect); LUSC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.62 -0.38 2.66e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg18765753 chr7:1198926 ZFAND2A -0.51 -9.4 -0.46 8.87e-19 Longevity;Endometriosis; LUSC cis rs10464366 0.746 rs12670510 chr7:39142146 A/G cg21665744 chr7:39171113 POU6F2 0.44 6.78 0.35 5.34e-11 IgG glycosylation; LUSC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -10.13 -0.48 3.18e-21 Glomerular filtration rate (creatinine); LUSC trans rs11039798 1.000 rs7131020 chr11:48642132 A/G cg15704280 chr7:45808275 SEPT13 0.71 6.73 0.35 7.39e-11 Axial length; LUSC cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg23711669 chr6:146136114 FBXO30 0.85 15.01 0.63 2.9e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs9329289 0.926 rs10903784 chr10:2541943 G/T cg15501526 chr10:2543763 NA -0.65 -12.27 -0.56 7.97e-29 Age-related hearing impairment; LUSC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg06008330 chr7:65541103 ASL -0.4 -6.24 -0.32 1.31e-9 Aortic root size; LUSC trans rs10432489 0.708 rs4436925 chr2:181755933 T/C cg04744134 chr19:8408128 KANK3 -0.8 -6.42 -0.33 4.8e-10 QT interval; LUSC cis rs61931739 0.929 rs2389272 chr12:34067771 T/C cg06521331 chr12:34319734 NA 0.37 6.3 0.33 9.33e-10 Morning vs. evening chronotype; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg02018176 chr4:1364513 KIAA1530 0.51 8.83 0.44 5.97e-17 Obesity-related traits; LUSC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg22532475 chr10:104410764 TRIM8 -0.34 -7.55 -0.38 4.14e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg12963246 chr6:28129442 ZNF389 0.41 6.5 0.33 3e-10 Parkinson's disease; LUSC cis rs1691799 0.899 rs1168300 chr12:66736467 C/A cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.45e-31 White blood cell count (basophil); LUSC cis rs595982 0.527 rs73061659 chr19:49373556 G/A cg15549821 chr19:49342101 PLEKHA4 -0.57 -7.5 -0.38 5.94e-13 Red cell distribution width; LUSC cis rs61931739 0.926 rs13377754 chr12:34051765 T/C cg06521331 chr12:34319734 NA 0.4 6.42 0.33 4.58e-10 Morning vs. evening chronotype; LUSC cis rs4919087 0.926 rs10882884 chr10:99025611 T/A cg25902810 chr10:99078978 FRAT1 0.46 6.57 0.34 1.9e-10 Monocyte count; LUSC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg04414720 chr1:150670196 GOLPH3L -0.56 -8.62 -0.43 2.68e-16 Melanoma; LUSC cis rs7173743 0.756 rs6495337 chr15:79125689 C/G cg00540400 chr15:79124168 NA -0.36 -6.29 -0.33 9.85e-10 Coronary artery disease; LUSC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg00383909 chr3:49044727 WDR6 0.41 5.73 0.3 2.23e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg02527881 chr3:46936655 PTH1R -0.39 -6.76 -0.35 6.22e-11 Colorectal cancer; LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -9.29 -0.45 2.08e-18 Monocyte percentage of white cells; LUSC cis rs1113500 0.730 rs1777456 chr1:108588472 G/A cg06207961 chr1:108661230 NA -0.31 -5.95 -0.31 6.65e-9 Growth-regulated protein alpha levels; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg18402987 chr7:1209562 NA 0.71 7.66 0.39 2.03e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg03060546 chr3:49711283 APEH 0.74 12.1 0.55 3.54e-28 Resting heart rate; LUSC cis rs1670533 1.000 rs11247971 chr4:1053580 A/G cg27284194 chr4:1044797 NA 0.59 8.97 0.44 2.1e-17 Recombination rate (females); LUSC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg25036284 chr2:26402008 FAM59B 0.74 10.17 0.49 2.35e-21 Gut microbiome composition (summer); LUSC trans rs11039798 0.588 rs7479642 chr11:48553808 G/T cg15704280 chr7:45808275 SEPT13 0.66 7.22 0.37 3.61e-12 Axial length; LUSC cis rs757081 0.667 rs17473243 chr11:17266259 G/A cg15432903 chr11:17409602 KCNJ11 -0.36 -5.75 -0.3 2.02e-8 Systolic blood pressure; LUSC cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg00857998 chr1:205179979 DSTYK 0.59 8.87 0.44 4.36e-17 Mean corpuscular volume;Mean platelet volume; LUSC trans rs62238980 0.614 rs118010731 chr22:32376308 G/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs1008375 1.000 rs10939744 chr4:17664473 G/T cg18681998 chr4:17616180 MED28 0.86 15.61 0.65 1.18e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg04369109 chr6:150039330 LATS1 -0.54 -7.45 -0.38 8.03e-13 Lung cancer; LUSC cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg00071950 chr4:10020882 SLC2A9 0.66 11.13 0.52 1.13e-24 Bone mineral density; LUSC cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg13852791 chr20:30311386 BCL2L1 -0.88 -11.63 -0.54 1.74e-26 Mean corpuscular hemoglobin; LUSC trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg03929089 chr4:120376271 NA -0.7 -8.57 -0.42 3.8e-16 Coronary artery disease; LUSC cis rs3808502 0.574 rs4841559 chr8:11416885 C/T cg27411982 chr8:10470053 RP1L1 -0.46 -6.97 -0.36 1.67e-11 Neuroticism; LUSC cis rs11190604 0.943 rs7900678 chr10:102229016 T/C cg16342193 chr10:102329863 NA -0.35 -6.28 -0.32 1.08e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.94 -0.4 3.19e-14 Lymphocyte counts; LUSC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7592578 0.664 rs10931461 chr2:191405280 T/A cg11845111 chr2:191398756 TMEM194B 0.86 11.02 0.52 2.76e-24 Diastolic blood pressure; LUSC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs4664304 0.772 rs6737904 chr2:160872526 G/C cg23995753 chr2:160760732 LY75 -0.34 -6.4 -0.33 5.21e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs11098499 0.954 rs10014845 chr4:120301077 T/G cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg13531842 chr10:38383804 ZNF37A -0.45 -7.02 -0.36 1.21e-11 Extrinsic epigenetic age acceleration; LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.69 -12.04 -0.55 5.48e-28 Prudent dietary pattern; LUSC cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg24130564 chr14:104152367 KLC1 0.68 10.95 0.51 4.91e-24 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs7188861 0.689 rs12600282 chr16:11401866 G/T cg00044050 chr16:11439710 C16orf75 0.6 6.49 0.33 3.19e-10 HDL cholesterol; LUSC cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg22681709 chr2:178499509 PDE11A -0.51 -9.14 -0.45 6.01e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg23034840 chr1:205782522 SLC41A1 0.66 9.67 0.47 1.12e-19 Menarche (age at onset); LUSC cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg16230307 chr14:35515116 FAM177A1 0.76 9.35 0.46 1.32e-18 Psoriasis; LUSC cis rs12545109 0.879 rs2609994 chr8:57365844 A/G cg09654669 chr8:57350985 NA -0.57 -7.46 -0.38 7.7e-13 Obesity-related traits; LUSC cis rs754466 0.580 rs10430529 chr10:79582623 C/A cg17075019 chr10:79541650 NA -0.77 -12.39 -0.56 2.84e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4566357 0.615 rs3769645 chr2:227913717 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -8.2 -0.41 5.4e-15 Coronary artery disease; LUSC cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg19628046 chr18:33552617 C18orf21 0.52 6.29 0.33 9.87e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs5770917 1.000 rs115743514 chr22:51011933 T/C cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.62 -5.75 -0.3 2.07e-8 Narcolepsy; LUSC cis rs34638657 0.732 rs11866711 chr16:82201038 A/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.33 -0.33 7.89e-10 Lung adenocarcinoma; LUSC cis rs7605827 0.930 rs10189403 chr2:15635664 T/A cg19274914 chr2:15703543 NA 0.47 9.12 0.45 7.34e-18 Educational attainment (years of education); LUSC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg12963246 chr6:28129442 ZNF389 0.52 7.17 0.37 4.94e-12 Depression; LUSC cis rs2361710 0.704 rs4889979 chr17:78121707 T/A cg09238746 chr17:78121135 EIF4A3 -0.65 -9.94 -0.48 1.47e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs6967385 0.604 rs10258470 chr7:12331516 A/G cg20607287 chr7:12443886 VWDE 0.37 5.82 0.3 1.38e-8 Response to taxane treatment (placlitaxel); LUSC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg08847533 chr14:75593920 NEK9 -0.84 -14.99 -0.63 3.37e-39 Height; LUSC cis rs4713118 0.699 rs200969 chr6:27859453 T/C cg19592336 chr6:28129416 ZNF389 0.44 5.87 0.31 1.04e-8 Parkinson's disease; LUSC cis rs9549260 0.569 rs117615233 chr13:41309223 G/A cg21288729 chr13:41239152 FOXO1 0.56 6.2 0.32 1.71e-9 Red blood cell count; LUSC cis rs7179456 0.593 rs514049 chr15:59042363 A/C cg05156742 chr15:59063176 FAM63B -0.49 -7.62 -0.38 2.63e-13 Asperger disorder; LUSC cis rs1983891 0.954 rs1886816 chr6:41544494 A/G cg20194872 chr6:41519635 FOXP4 0.37 6.49 0.33 3.11e-10 Prostate cancer; LUSC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg11764359 chr7:65958608 NA 0.72 11.26 0.52 3.69e-25 Aortic root size; LUSC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg13607699 chr17:42295918 UBTF 0.52 8.23 0.41 4.32e-15 Total body bone mineral density; LUSC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg23711669 chr6:146136114 FBXO30 0.87 16.09 0.66 1.53e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs68170813 0.559 rs2107319 chr7:106863744 T/C cg02696742 chr7:106810147 HBP1 -0.63 -9.66 -0.47 1.24e-19 Coronary artery disease; LUSC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg00745463 chr17:30367425 LRRC37B -0.85 -9.62 -0.47 1.75e-19 Hip circumference adjusted for BMI; LUSC cis rs16910800 0.731 rs16910759 chr11:23192131 C/G cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC trans rs7681440 0.904 rs1372521 chr4:90765223 G/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs908922 0.676 rs10788842 chr1:152514588 A/T cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs4631830 0.812 rs11593361 chr10:51539156 A/G cg16070123 chr10:51489643 NA -0.48 -7.57 -0.38 3.59e-13 Prostate-specific antigen levels; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -7.46 -0.38 7.72e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4148883 0.689 rs1869458 chr4:100024728 C/G cg12011299 chr4:100065546 ADH4 0.48 7.93 0.4 3.26e-14 Alcohol dependence; LUSC trans rs61931739 0.500 rs7489132 chr12:34539712 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs6545883 0.826 rs2694617 chr2:61537214 G/A cg15711740 chr2:61764176 XPO1 0.44 6.92 0.35 2.3e-11 Tuberculosis; LUSC cis rs1790761 0.967 rs1790753 chr11:67201008 C/T cg24690094 chr11:67383802 NA -0.32 -6.03 -0.31 4.35e-9 Mean corpuscular volume; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.45 6.16 0.32 2.15e-9 Renal function-related traits (BUN); LUSC cis rs11048434 0.761 rs12827988 chr12:9130287 A/G cg13575925 chr12:9217583 LOC144571 0.34 6.18 0.32 1.92e-9 Sjögren's syndrome; LUSC cis rs7264396 1.000 rs224409 chr20:34124920 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.37 -0.37 1.31e-12 Total cholesterol levels; LUSC cis rs7315438 0.629 rs4767324 chr12:115920020 A/T cg24172291 chr12:115889509 NA -0.34 -5.67 -0.3 3.17e-8 Colorectal cancer; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03633073 chr16:89437518 ANKRD11 -0.34 -5.97 -0.31 5.9e-9 Asthma; LUSC cis rs7315438 0.560 rs12829606 chr12:115889424 G/A cg24172291 chr12:115889509 NA -0.37 -6.25 -0.32 1.22e-9 Colorectal cancer; LUSC cis rs9788682 0.633 rs2656070 chr15:78730252 A/G cg18825076 chr15:78729989 IREB2 -0.45 -6.13 -0.32 2.53e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1559088 0.948 rs10408093 chr19:33597816 T/C cg03563238 chr19:33554763 RHPN2 -0.41 -6.56 -0.34 2.09e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs5758511 0.773 rs9680671 chr22:42351477 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.46 -5.7 -0.3 2.68e-8 Birth weight; LUSC cis rs76419734 0.510 rs2553461 chr4:106731410 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.57 -6.56 -0.34 2.05e-10 Post bronchodilator FEV1; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg20295408 chr7:1910781 MAD1L1 -0.49 -7.09 -0.36 8.28e-12 Bipolar disorder and schizophrenia; LUSC cis rs1355223 0.583 rs2956076 chr11:34874124 T/C cg11058730 chr11:34937778 PDHX;APIP 0.67 10.61 0.5 7.13e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6500602 0.727 rs4786516 chr16:4578641 C/T cg08645402 chr16:4508243 NA 0.52 8.82 0.43 6.66e-17 Schizophrenia; LUSC cis rs12532214 0.724 rs79042841 chr7:3160660 T/C cg19214707 chr7:3157722 NA -0.48 -7.65 -0.39 2.13e-13 Itch intensity from mosquito bite; LUSC cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg25427524 chr10:38739819 LOC399744 -0.57 -10.13 -0.48 3.24e-21 Extrinsic epigenetic age acceleration; LUSC trans rs2898290 0.622 rs1382567 chr8:11350899 T/C cg06636001 chr8:8085503 FLJ10661 -0.53 -8.23 -0.41 4.17e-15 Systolic blood pressure; LUSC cis rs7178572 0.568 rs11854193 chr15:77458136 C/A cg22256960 chr15:77711686 NA -0.5 -7.95 -0.4 2.97e-14 Type 2 diabetes; LUSC cis rs273573 1.000 rs273559 chr11:30923223 C/T cg14844989 chr11:31128820 NA 0.36 5.72 0.3 2.34e-8 Total body bone mineral density; LUSC cis rs9467773 0.620 rs2494696 chr6:26620894 A/G cg11502198 chr6:26597334 ABT1 0.7 11.83 0.54 3.39e-27 Intelligence (multi-trait analysis); LUSC cis rs7804356 1.000 rs10236221 chr7:26884671 A/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs477692 0.837 rs543454 chr10:131420536 T/C cg26102564 chr10:131424627 MGMT 0.36 5.69 0.3 2.74e-8 Response to temozolomide; LUSC cis rs12540874 0.931 rs4245555 chr7:50661409 A/G cg18232548 chr7:50535776 DDC -0.45 -6.42 -0.33 4.65e-10 Systemic sclerosis; LUSC cis rs908922 0.676 rs2181172 chr1:152491794 A/G cg20991723 chr1:152506922 NA 0.54 10.25 0.49 1.33e-21 Hair morphology; LUSC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg01416388 chr22:39784598 NA -0.41 -6.82 -0.35 4.25e-11 Intelligence (multi-trait analysis); LUSC cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.17 0.37 4.94e-12 Cognitive ability; LUSC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg06238570 chr21:40685208 BRWD1 -0.6 -10.13 -0.48 3.39e-21 Cognitive function; LUSC cis rs2115630 1.000 rs6496452 chr15:85372645 A/T cg09876464 chr15:85330779 ZNF592 0.36 6.77 0.35 5.7e-11 P wave terminal force; LUSC cis rs73416724 1.000 rs4714675 chr6:43287893 T/C cg26312998 chr6:43337775 ZNF318 -0.54 -6.27 -0.32 1.11e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg13206674 chr6:150067644 NUP43 0.55 8.15 0.41 7.32e-15 Lung cancer; LUSC cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg00321850 chr1:175162397 KIAA0040 -0.45 -7.72 -0.39 1.39e-13 Alcohol dependence; LUSC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg25019033 chr10:957182 NA -0.5 -6.45 -0.33 4.01e-10 Eosinophil percentage of granulocytes; LUSC cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg26384229 chr12:38710491 ALG10B 0.93 15.98 0.66 4.19e-43 Morning vs. evening chronotype; LUSC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg06238570 chr21:40685208 BRWD1 0.47 7.38 0.37 1.27e-12 Cognitive function; LUSC cis rs6845621 0.901 rs7684274 chr4:18920249 C/A cg12196642 chr4:18937545 NA -0.36 -6.76 -0.35 6.11e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg21724239 chr8:58056113 NA 0.77 9.21 0.45 3.76e-18 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.76 10.56 0.5 1.14e-22 Cognitive test performance; LUSC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg12863693 chr15:85201151 NMB -0.26 -5.78 -0.3 1.67e-8 P wave terminal force; LUSC cis rs2901656 0.967 rs4916186 chr1:172396020 A/G cg03748243 chr1:172413542 C1orf105;PIGC 0.31 6.13 0.32 2.44e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs7903847 0.642 rs11812223 chr10:99158455 T/C cg20016023 chr10:99160130 RRP12 -0.33 -8.1 -0.41 1.04e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs80282103 0.764 rs7093915 chr10:1107341 A/G cg18964960 chr10:1102726 WDR37 -0.67 -6.17 -0.32 1.95e-9 Glomerular filtration rate (creatinine); LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg00149659 chr3:10157352 C3orf10 0.91 13.04 0.58 1.03e-31 Alzheimer's disease; LUSC cis rs2455601 1.000 rs11042114 chr11:8919889 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -7.85 -0.39 5.64e-14 Schizophrenia; LUSC cis rs7614311 0.731 rs56263032 chr3:63863022 G/A cg22134162 chr3:63841271 THOC7 -0.49 -6.07 -0.32 3.43e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg26354017 chr1:205819088 PM20D1 0.86 15.58 0.65 1.6e-41 Menarche (age at onset); LUSC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg03036452 chr22:46663545 TTC38 0.54 5.89 0.31 9.38e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg24531977 chr5:56204891 C5orf35 -0.8 -11.83 -0.54 3.29e-27 Coronary artery disease; LUSC cis rs9650657 0.589 rs6985109 chr8:10761585 A/G cg27411982 chr8:10470053 RP1L1 0.49 7.32 0.37 1.82e-12 Neuroticism; LUSC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -6.9 -0.35 2.59e-11 Alzheimer's disease (late onset); LUSC cis rs10876993 0.890 rs115106209 chr12:58059331 G/A cg18357645 chr12:58087776 OS9 0.55 8.34 0.42 1.95e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs7760949 0.963 rs1330117 chr6:13920926 C/T cg27413430 chr6:13925136 RNF182 0.54 8.04 0.4 1.58e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg03354898 chr7:1950403 MAD1L1 -0.43 -8.68 -0.43 1.75e-16 Bipolar disorder and schizophrenia; LUSC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg18681998 chr4:17616180 MED28 0.77 13.88 0.6 6.68e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.54 0.5 1.27e-22 Menopause (age at onset); LUSC cis rs11155671 0.530 rs9383940 chr6:150226059 T/G cg09699651 chr6:150184138 LRP11 0.46 7.32 0.37 1.82e-12 Testicular germ cell tumor; LUSC cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg13334819 chr7:99746414 C7orf59 -0.43 -5.82 -0.3 1.36e-8 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02622885 chr11:14913424 CYP2R1 0.42 6.09 0.32 3.12e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs57590327 0.503 rs13073613 chr3:81888512 C/A cg07356753 chr3:81810745 GBE1 -0.65 -10.18 -0.49 2.19e-21 Extraversion; LUSC trans rs61931739 0.817 rs11833948 chr12:34276942 G/T cg13010199 chr12:38710504 ALG10B 0.4 6.31 0.33 8.95e-10 Morning vs. evening chronotype; LUSC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg03806693 chr22:41940476 POLR3H 0.95 12.17 0.55 1.93e-28 Vitiligo; LUSC cis rs6076065 0.723 rs8183442 chr20:23415563 C/T cg11657817 chr20:23433608 CST11 0.41 7.31 0.37 1.98e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg12311346 chr5:56204834 C5orf35 -0.61 -9.32 -0.45 1.66e-18 Coronary artery disease; LUSC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12756686 chr19:29218302 NA 0.67 9.88 0.48 2.22e-20 Methadone dose in opioid dependence; LUSC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg07701084 chr6:150067640 NUP43 0.55 8.19 0.41 5.63e-15 Lung cancer; LUSC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.82 -0.3 1.42e-8 Parkinson's disease; LUSC cis rs28655083 0.529 rs285019 chr16:77099450 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.42 6.73 0.35 7.57e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7189233 0.550 rs4783811 chr16:53483376 A/G cg09728985 chr16:53543985 NA -0.32 -6.04 -0.31 4.06e-9 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.542 rs5769751 chr22:50242733 T/G cg02269571 chr22:50332266 NA 0.78 8.46 0.42 8.77e-16 Schizophrenia; LUSC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg16372103 chr5:203701 NA 0.44 5.77 0.3 1.76e-8 Breast cancer; LUSC cis rs6732160 0.510 rs57825971 chr2:73384796 C/G cg24220031 chr2:73402428 NA -0.26 -6.05 -0.31 3.89e-9 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg18099408 chr3:52552593 STAB1 -0.4 -6.92 -0.35 2.26e-11 Bipolar disorder; LUSC cis rs1163251 0.837 rs592762 chr1:120247355 A/G cg19096424 chr1:120255104 PHGDH 0.44 6.07 0.32 3.48e-9 Blood metabolite levels; LUSC cis rs2836633 0.895 rs61085980 chr21:40032140 C/T cg12884169 chr21:40033163 ERG 0.61 12.48 0.56 1.35e-29 Coronary artery disease; LUSC trans rs72674100 1.000 rs10027971 chr4:97967340 T/C cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs478304 0.934 rs610037 chr11:65546857 A/C cg05805236 chr11:65401703 PCNXL3 0.41 6.87 0.35 3.16e-11 Acne (severe); LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg01802117 chr1:53393560 SCP2 -0.43 -7.25 -0.37 2.88e-12 Monocyte count; LUSC trans rs1325195 0.881 rs2816185 chr1:179117740 C/T cg11624085 chr17:8464688 MYH10 0.43 7.08 0.36 8.7e-12 IgE grass sensitization; LUSC cis rs6669072 0.804 rs1307511 chr1:91312880 T/G cg08895590 chr1:91227319 NA 0.33 7.14 0.36 5.72e-12 Cognitive function; LUSC cis rs9393777 0.623 rs56296968 chr6:26474571 C/T cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg23630131 chr7:65973040 NA -0.2 -5.64 -0.3 3.55e-8 Aortic root size; LUSC trans rs6601327 0.540 rs6982148 chr8:9581070 G/C cg15556689 chr8:8085844 FLJ10661 -0.46 -6.6 -0.34 1.57e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg00106254 chr7:1943704 MAD1L1 -0.41 -5.89 -0.31 9.36e-9 Bipolar disorder and schizophrenia; LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg07092213 chr7:1199455 ZFAND2A -0.45 -6.98 -0.36 1.57e-11 Longevity;Endometriosis; LUSC trans rs1728785 0.901 rs1103286 chr16:68578625 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.52 0.38 4.99e-13 Ulcerative colitis; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg13395646 chr4:1353034 KIAA1530 0.58 8.88 0.44 4.07e-17 Obesity-related traits; LUSC cis rs7223966 1.000 rs55868506 chr17:61851686 T/G cg00945038 chr17:61921165 SMARCD2 0.4 6.07 0.32 3.45e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg20790798 chr5:1857306 NA -0.49 -8.52 -0.42 5.68e-16 Cardiovascular disease risk factors; LUSC cis rs9943753 0.508 rs2075433 chr12:109833920 A/G cg19025524 chr12:109796872 NA -0.38 -6.98 -0.36 1.59e-11 HDL cholesterol; LUSC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg12463550 chr7:65579703 CRCP 0.57 8.49 0.42 6.88e-16 Aortic root size; LUSC trans rs4843747 0.671 rs8053377 chr16:88106465 A/G cg26811252 chr16:29126840 RRN3P2 0.57 9.03 0.44 1.41e-17 Menopause (age at onset); LUSC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg13877915 chr19:58951672 ZNF132 0.51 8.17 0.41 6.59e-15 Uric acid clearance; LUSC cis rs6960043 0.818 rs1974620 chr7:15065467 A/G cg19272540 chr7:15055459 NA 0.28 6.93 0.35 2.15e-11 Type 2 diabetes; LUSC cis rs644148 0.836 rs2686774 chr19:44999827 T/C cg15540054 chr19:45004280 ZNF180 -0.63 -9.36 -0.46 1.18e-18 Personality dimensions; LUSC cis rs12760731 0.565 rs12026482 chr1:178155861 G/A cg00404053 chr1:178313656 RASAL2 0.66 6.8 0.35 4.85e-11 Obesity-related traits; LUSC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg04362960 chr10:104952993 NT5C2 -0.52 -6.15 -0.32 2.23e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.08 0.44 1e-17 Tonsillectomy; LUSC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg10802521 chr3:52805072 NEK4 -0.52 -8.38 -0.42 1.51e-15 Bipolar disorder; LUSC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.7 9.11 0.45 7.86e-18 Menarche (age at onset); LUSC cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg16797656 chr11:68205561 LRP5 0.36 6.06 0.31 3.62e-9 Total body bone mineral density; LUSC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.03 -0.31 4.27e-9 Major depressive disorder; LUSC cis rs2404602 0.692 rs35557205 chr15:77130711 T/G cg22467129 chr15:76604101 ETFA -0.47 -7.24 -0.37 3.05e-12 Blood metabolite levels; LUSC cis rs11997175 0.574 rs10954931 chr8:33631066 A/T ch.8.33884649F chr8:33765107 NA 0.52 8.52 0.42 5.64e-16 Body mass index; LUSC cis rs7824557 0.564 rs2437152 chr8:11235497 G/A cg21775007 chr8:11205619 TDH -0.65 -10.3 -0.49 9.02e-22 Retinal vascular caliber; LUSC trans rs3857536 0.740 rs4710571 chr6:66890250 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC cis rs3772130 0.962 rs9822949 chr3:121541239 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.68 10.13 0.48 3.31e-21 Cognitive performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23624671 chr1:63833285 ALG6 -0.4 -5.98 -0.31 5.71e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7618501 0.521 rs2883059 chr3:49902160 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -8.45 -0.42 9.32e-16 Intelligence (multi-trait analysis); LUSC cis rs4900538 0.855 rs12586378 chr14:102853150 T/C cg18135206 chr14:102964638 TECPR2 -1.01 -20.01 -0.74 4.04e-59 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg20821713 chr7:1055600 C7orf50 -0.46 -6.83 -0.35 4e-11 Bronchopulmonary dysplasia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13682704 chr9:131549543 TBC1D13 -0.42 -6.22 -0.32 1.51e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3008870 0.920 rs12132532 chr1:67457015 G/T cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.06 -0.64 1.78e-39 Lymphocyte percentage of white cells; LUSC trans rs6445525 1.000 rs6445525 chr3:65993104 C/G cg12639933 chr12:57626296 SHMT2 -0.35 -6.34 -0.33 7.49e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9303401 0.659 rs34426768 chr17:56683385 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.78 0.57 9.84e-31 Cognitive test performance; LUSC cis rs17270561 0.609 rs9358885 chr6:25758024 T/C cg17691542 chr6:26056736 HIST1H1C 0.59 8.07 0.4 1.3e-14 Iron status biomarkers; LUSC cis rs447735 0.587 rs11640702 chr16:89729169 A/G cg04240660 chr16:89714849 CHMP1A 0.41 6.43 0.33 4.3e-10 Hemoglobin concentration; LUSC cis rs344364 0.602 rs2983907 chr16:1913336 C/T cg00564555 chr16:1970112 NA 0.37 6.36 0.33 6.54e-10 Glomerular filtration rate in chronic kidney disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12799349 chr18:9475500 RALBP1 -0.53 -6.18 -0.32 1.88e-9 Bipolar disorder and schizophrenia; LUSC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg10523679 chr1:76189770 ACADM 0.84 12.97 0.58 1.93e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6433857 0.536 rs1901750 chr2:181350739 C/T cg23363182 chr2:181467187 NA -0.44 -7.18 -0.37 4.61e-12 Body mass index; LUSC cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg26384229 chr12:38710491 ALG10B 0.92 15.51 0.65 2.92e-41 Bladder cancer; LUSC cis rs714027 1.000 rs2412975 chr22:30540590 T/C cg11564601 chr22:30592435 NA -0.37 -6.81 -0.35 4.67e-11 Lymphocyte counts; LUSC cis rs2324229 0.927 rs1180195 chr6:83960862 C/T cg08257003 chr6:84140564 ME1 0.31 7.07 0.36 8.83e-12 Platelet-derived growth factor BB levels; LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg08859206 chr1:53392774 SCP2 -0.54 -9.02 -0.44 1.47e-17 Monocyte count; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg23102388 chr7:1867652 MAD1L1 -0.32 -5.81 -0.3 1.5e-8 Bipolar disorder and schizophrenia; LUSC cis rs597583 0.664 rs4936384 chr11:117398591 C/T cg27161313 chr11:117392002 DSCAML1 -0.43 -7.2 -0.37 3.96e-12 Putamen volume; LUSC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg25319279 chr11:5960081 NA -0.41 -5.72 -0.3 2.4e-8 DNA methylation (variation); LUSC cis rs1018836 0.828 rs7014967 chr8:91557843 G/T cg16814680 chr8:91681699 NA -0.69 -11.18 -0.52 7.13e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7582180 0.629 rs12620139 chr2:100943446 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.6 -0.43 3.2e-16 Intelligence (multi-trait analysis); LUSC trans rs7980799 0.649 rs1994135 chr12:33682405 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.63 0.39 2.44e-13 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs3126085 0.935 rs7533529 chr1:152176871 T/C cg03465714 chr1:152285911 FLG -0.41 -5.71 -0.3 2.54e-8 Atopic dermatitis; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg02773601 chr12:57623994 SHMT2 -0.5 -6.22 -0.32 1.49e-9 Neuroticism; LUSC cis rs4851254 0.660 rs74340261 chr2:100696827 C/T cg07810366 chr2:100720526 AFF3 -0.45 -6.02 -0.31 4.59e-9 Intelligence (multi-trait analysis); LUSC cis rs9400467 0.528 rs455726 chr6:111699368 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg20283391 chr11:68216788 NA -0.6 -8.41 -0.42 1.24e-15 Total body bone mineral density; LUSC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg16423285 chr20:60520624 NA 0.63 8.06 0.4 1.35e-14 Body mass index; LUSC cis rs4988958 0.565 rs1420100 chr2:103037002 C/A cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.35e-12 Asthma (childhood onset); LUSC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg24838063 chr12:130822603 PIWIL1 -0.63 -10.05 -0.48 6.13e-21 Menopause (age at onset); LUSC cis rs2692947 0.832 rs4907212 chr2:96410048 T/A cg22654517 chr2:96458247 NA 0.37 7.48 0.38 6.63e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4443100 0.670 rs9612225 chr22:23406619 G/A cg21100191 chr22:23484243 RTDR1 0.56 7.07 0.36 9e-12 Serum parathyroid hormone levels; LUSC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg12310025 chr6:25882481 NA -0.48 -8.98 -0.44 2.06e-17 Blood metabolite levels; LUSC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg15649852 chr7:65879115 NA 0.42 5.85 0.31 1.15e-8 Aortic root size; LUSC trans rs800082 0.698 rs1178943 chr3:144391772 T/G cg24215973 chr2:240111563 HDAC4 -0.72 -10.41 -0.49 3.63e-22 Smoking behavior; LUSC cis rs9434723 0.844 rs2268174 chr1:9300668 C/A cg04199779 chr1:9294473 H6PD 0.51 6.02 0.31 4.5e-9 Height; LUSC cis rs1461503 0.932 rs56778812 chr11:122840491 C/T cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs2204008 0.619 rs11178987 chr12:38201258 C/T cg26384229 chr12:38710491 ALG10B -0.68 -10.5 -0.5 1.71e-22 Bladder cancer; LUSC cis rs11190604 0.943 rs11190568 chr10:102224277 C/T cg16342193 chr10:102329863 NA -0.36 -6.19 -0.32 1.74e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs17030434 0.953 rs12639885 chr4:154700374 G/A cg14289246 chr4:154710475 SFRP2 -0.51 -6.64 -0.34 1.28e-10 Electrocardiographic conduction measures; LUSC cis rs1003719 0.715 rs6579 chr21:38568308 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.2 -0.49 1.9e-21 Eye color traits; LUSC cis rs7568458 0.870 rs1010 chr2:85808982 C/T cg02493740 chr2:85810744 VAMP5 0.32 5.72 0.3 2.43e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg02782426 chr3:40428986 ENTPD3 0.39 7.43 0.38 9.35e-13 Renal cell carcinoma; LUSC cis rs9430161 0.579 rs7542354 chr1:11040385 G/A cg27631724 chr1:11040367 C1orf127 0.56 10.92 0.51 6.1e-24 Ewing sarcoma; LUSC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg10523679 chr1:76189770 ACADM 0.88 14.1 0.61 9.28e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs62400317 0.723 rs1329709 chr6:44974956 G/T cg18551225 chr6:44695536 NA -0.43 -6.89 -0.35 2.83e-11 Total body bone mineral density; LUSC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg25258033 chr6:167368657 RNASET2 0.47 7.42 0.38 9.92e-13 Crohn's disease; LUSC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg24675658 chr1:53192096 ZYG11B 0.75 12.88 0.58 4.33e-31 Monocyte count; LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg04267008 chr7:1944627 MAD1L1 -0.46 -6.97 -0.36 1.74e-11 Bipolar disorder and schizophrenia; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1950626 0.743 rs1956734 chr14:101399830 A/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.35 -6.31 -0.33 8.91e-10 Pelvic organ prolapse (moderate/severe); LUSC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg12463550 chr7:65579703 CRCP 0.45 6.71 0.34 8.11e-11 Aortic root size; LUSC cis rs5769707 0.521 rs5770633 chr22:50062427 G/A cg20744362 chr22:50050164 C22orf34 0.35 6.29 0.33 9.69e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.84 0.3 1.21e-8 Intelligence (multi-trait analysis); LUSC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg16049864 chr8:95962084 TP53INP1 -0.68 -13.49 -0.59 2.08e-33 Type 2 diabetes; LUSC cis rs7191700 0.836 rs28502009 chr16:11426541 G/A cg00044050 chr16:11439710 C16orf75 0.58 8.55 0.42 4.56e-16 Multiple sclerosis; LUSC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg15605315 chr1:45957053 TESK2 0.5 8.48 0.42 7.48e-16 High light scatter reticulocyte count; LUSC trans rs877282 0.891 rs10904557 chr10:797490 C/T cg22713356 chr15:30763199 NA -1.09 -16.28 -0.67 2.81e-44 Uric acid levels; LUSC cis rs7937682 0.814 rs1619652 chr11:111469757 G/A cg11344533 chr11:111475393 SIK2 -0.49 -6.66 -0.34 1.14e-10 Primary sclerosing cholangitis; LUSC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs7408868 0.908 rs62113793 chr19:15277336 G/A cg14696996 chr19:15285081 NOTCH3 0.96 8.62 0.43 2.65e-16 Pulse pressure; LUSC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg05805236 chr11:65401703 PCNXL3 -0.38 -5.79 -0.3 1.62e-8 Breast cancer; LUSC trans rs4714291 0.802 rs911818 chr6:39988816 C/A cg02267698 chr19:7991119 CTXN1 -0.53 -7.85 -0.39 5.68e-14 Strep throat; LUSC cis rs908922 0.676 rs7529441 chr1:152531629 A/G cg20991723 chr1:152506922 NA -0.51 -9.57 -0.46 2.46e-19 Hair morphology; LUSC cis rs950027 0.596 rs2467865 chr15:45638307 T/C cg26924012 chr15:45694286 SPATA5L1 0.78 12.36 0.56 3.65e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs7618501 1.000 rs6802890 chr3:49832261 A/G cg24110177 chr3:50126178 RBM5 -0.42 -6.7 -0.34 9e-11 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.737 rs7595979 chr2:238364492 G/T cg16989719 chr2:238392110 NA -0.4 -6.89 -0.35 2.76e-11 Prostate cancer; LUSC cis rs1322512 0.917 rs2758769 chr6:152986717 G/A cg27316956 chr6:152958899 SYNE1 0.37 6.32 0.33 8.37e-10 Tonometry; LUSC trans rs1949829 0.826 rs4947595 chr7:51537062 G/T cg20941110 chr15:83953819 BNC1 0.55 6.01 0.31 4.98e-9 Wegener's granulomatosis; LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg13395646 chr4:1353034 KIAA1530 -0.56 -8.08 -0.4 1.22e-14 Longevity; LUSC trans rs1493916 0.870 rs1389531 chr18:31386616 C/T cg13755796 chr4:20253514 NA -0.41 -6.4 -0.33 5.28e-10 Life satisfaction; LUSC cis rs9818941 0.824 rs9838352 chr3:157760461 C/A cg08654915 chr3:157813417 NA -0.32 -7.49 -0.38 6.2e-13 Height; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs5756813 0.688 rs56114444 chr22:38123364 C/T cg06521852 chr22:38141419 TRIOBP 0.41 6.16 0.32 2.04e-9 Optic cup area;Vertical cup-disc ratio; LUSC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg22029157 chr1:209979665 IRF6 -0.78 -9.37 -0.46 1.13e-18 Cleft lip with or without cleft palate; LUSC cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg03146154 chr1:46216737 IPP 0.56 8.39 0.42 1.39e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7267979 0.866 rs2424698 chr20:25256106 C/T cg03522245 chr20:25566470 NINL 0.36 5.88 0.31 9.79e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.59 -0.34 1.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs600231 0.665 rs1616810 chr11:65220105 A/G cg17120908 chr11:65337727 SSSCA1 -0.52 -9.27 -0.45 2.38e-18 Bone mineral density; LUSC trans rs11098499 0.955 rs1551 chr4:120158500 T/G cg25214090 chr10:38739885 LOC399744 0.45 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg22800045 chr5:56110881 MAP3K1 0.77 9.96 0.48 1.24e-20 Initial pursuit acceleration; LUSC cis rs977987 0.872 rs4887825 chr16:75472422 C/A cg03315344 chr16:75512273 CHST6 0.5 9.65 0.47 1.32e-19 Dupuytren's disease; LUSC trans rs1486139 0.967 rs13234885 chr7:46290701 C/A cg17534202 chr9:96721102 NA -0.37 -6.63 -0.34 1.3100000000000001e-10 Select biomarker traits; LUSC cis rs61931739 0.500 rs34997501 chr12:34549828 C/G cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs7267979 1.000 rs13038834 chr20:25441433 C/T cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.12e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1801251 1.000 rs2100053 chr2:233719516 G/T cg25237894 chr2:233734115 C2orf82 -0.37 -6.93 -0.35 2.18e-11 Coronary artery disease; LUSC cis rs4803468 0.934 rs2317131 chr19:41885151 C/T cg09537434 chr19:41945824 ATP5SL -0.87 -15.12 -0.64 1.01e-39 Height; LUSC cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -6.82 -0.35 4.35e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9522267 0.535 rs9522305 chr13:112237550 A/G cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 3e-8 Hepatitis; LUSC cis rs590121 0.830 rs615896 chr11:75275301 T/C cg26104986 chr11:75275303 SERPINH1 -0.28 -5.75 -0.3 2.02e-8 Coronary artery disease; LUSC cis rs6500395 1.000 rs11076578 chr16:48714520 C/G cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs8077889 1.000 rs17675122 chr17:41886190 A/G cg26893861 chr17:41843967 DUSP3 1.0 14.9 0.63 7.8e-39 Triglycerides; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg08888203 chr3:10149979 C3orf24 0.64 8.98 0.44 2.07e-17 Alzheimer's disease; LUSC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg01416388 chr22:39784598 NA -0.42 -6.89 -0.35 2.75e-11 Intelligence (multi-trait analysis); LUSC cis rs6599077 0.802 rs17075717 chr3:40139432 G/C cg13683864 chr3:40499215 RPL14 -0.52 -6.57 -0.34 1.94e-10 Sleep-related phenotypes; LUSC cis rs11098499 0.954 rs10031483 chr4:120422636 T/C cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg25456477 chr12:86230367 RASSF9 0.35 6.25 0.32 1.24e-9 Major depressive disorder; LUSC cis rs2274273 1.000 rs7160110 chr14:55594635 A/G cg04306507 chr14:55594613 LGALS3 0.57 13.06 0.58 9.13e-32 Protein biomarker; LUSC trans rs2243480 1.000 rs316325 chr7:65609518 G/A cg10756647 chr7:56101905 PSPH 0.88 8.91 0.44 3.39e-17 Diabetic kidney disease; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 22.61 0.78 2.65e-69 Prudent dietary pattern; LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg08219700 chr8:58056026 NA 0.64 8.1 0.41 1.03e-14 Developmental language disorder (linguistic errors); LUSC cis rs17597773 0.527 rs2484698 chr1:221086065 A/T cg16008148 chr1:221062819 NA -0.38 -6.97 -0.36 1.72e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9398803 0.865 rs2130603 chr6:126826819 A/C cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 2.02e-9 Male-pattern baldness; LUSC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg03060546 chr3:49711283 APEH 0.73 11.98 0.55 9.72e-28 Resting heart rate; LUSC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 -0.47 -7.19 -0.37 4.2e-12 Vitiligo; LUSC cis rs7580658 0.724 rs6712213 chr2:127998230 G/A cg09760422 chr2:128146352 NA -0.31 -6.86 -0.35 3.3e-11 Protein C levels; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg04234412 chr22:24373322 LOC391322 -0.94 -16.72 -0.68 4.98e-46 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs67460515 0.527 rs34221255 chr3:160854123 T/C cg03342759 chr3:160939853 NMD3 -0.44 -6.3 -0.33 9.36e-10 Parkinson's disease; LUSC cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -7.44 -0.38 8.71e-13 Chronic sinus infection; LUSC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11644478 chr21:40555479 PSMG1 0.95 18.81 0.72 2.51e-54 Cognitive function; LUSC cis rs72827839 0.516 rs72833458 chr17:45938051 A/G cg23391107 chr17:45924227 SP6 0.43 7.68 0.39 1.78e-13 Ease of getting up in the morning; LUSC cis rs765787 0.530 rs28524974 chr15:45543528 C/T cg25801113 chr15:45476975 SHF 0.34 6.85 0.35 3.49e-11 Uric acid levels; LUSC trans rs76248362 0.867 rs74657221 chr13:24431809 G/C cg26511321 chr7:27196790 HOXA7 -0.57 -5.99 -0.31 5.48e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg02398342 chr17:80708632 TBCD;FN3K -0.47 -7.56 -0.38 3.96e-13 Glycated hemoglobin levels; LUSC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg11663144 chr21:46675770 NA 0.43 7.63 0.39 2.45e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs600231 0.598 rs2508712 chr11:65232261 C/G cg21890820 chr11:65308645 LTBP3 0.5 7.41 0.38 1.03e-12 Bone mineral density; LUSC cis rs9650657 0.682 rs6989160 chr8:10705360 A/C cg27411982 chr8:10470053 RP1L1 -0.4 -6.53 -0.34 2.42e-10 Neuroticism; LUSC cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg06641503 chr3:48959341 ARIH2 -0.39 -5.94 -0.31 7.17e-9 Parkinson's disease; LUSC trans rs2055729 1.000 rs2055729 chr8:9792662 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.25 -0.32 1.26e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg05855489 chr10:104503620 C10orf26 0.61 9.8 0.47 4.43e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17433780 0.964 rs12146148 chr1:89471892 C/T cg09516651 chr1:89888402 LOC400759 0.49 8.21 0.41 4.91e-15 Carotid intima media thickness; LUSC cis rs6495122 0.630 rs12912343 chr15:75251041 C/G cg17294928 chr15:75287854 SCAMP5 0.41 5.81 0.3 1.49e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg13798780 chr7:105162888 PUS7 0.56 6.19 0.32 1.81e-9 Bipolar disorder (body mass index interaction); LUSC cis rs16854884 0.770 rs951865 chr3:143812677 G/A cg06585982 chr3:143692056 C3orf58 0.44 6.49 0.33 3.18e-10 Economic and political preferences (feminism/equality); LUSC cis rs2227930 0.506 rs7623785 chr3:142119140 T/C cg16271453 chr3:142027066 XRN1 -0.54 -9.63 -0.47 1.61e-19 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs17433780 0.808 rs7541867 chr1:89513537 G/A cg09516651 chr1:89888402 LOC400759 0.61 11.66 0.54 1.34e-26 Carotid intima media thickness; LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg16325326 chr1:53192061 ZYG11B 0.81 14.3 0.62 1.62e-36 Monocyte count; LUSC cis rs34779708 0.966 rs35777088 chr10:35409048 T/C cg03585969 chr10:35415529 CREM 0.62 8.97 0.44 2.2e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.75 0.39 1.1e-13 Lung function (FEV1/FVC); LUSC cis rs6736093 1.000 rs13006203 chr2:112661150 G/A cg12686935 chr2:112915763 FBLN7 -0.39 -5.99 -0.31 5.37e-9 Coronary artery disease; LUSC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.48 0.42 7.57e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs981844 0.857 rs62325140 chr4:154714161 C/A cg14289246 chr4:154710475 SFRP2 0.48 6.08 0.32 3.28e-9 Response to statins (LDL cholesterol change); LUSC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.75 9.51 0.46 3.99e-19 Glomerular filtration rate in chronic kidney disease; LUSC cis rs1691799 0.899 rs1168321 chr12:66744517 C/G cg16791601 chr12:66731901 HELB 0.71 12.53 0.57 8.86e-30 White blood cell count (basophil); LUSC cis rs12310956 0.532 rs11052948 chr12:33981973 T/C cg06521331 chr12:34319734 NA -0.46 -7.33 -0.37 1.72e-12 Morning vs. evening chronotype; LUSC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg06028605 chr16:24865363 SLC5A11 -0.4 -6.37 -0.33 6.39e-10 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs35106985 chr10:102307542 T/C cg07080220 chr10:102295463 HIF1AN 0.68 9.3 0.45 1.86e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg21951975 chr1:209979733 IRF6 0.62 8.2 0.41 5.31e-15 Cleft lip with or without cleft palate; LUSC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.93e-11 Blood metabolite levels; LUSC cis rs34172651 0.917 rs12599173 chr16:24823619 T/C cg00152838 chr16:24741724 TNRC6A -0.43 -5.65 -0.3 3.5e-8 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg23281280 chr6:28129359 ZNF389 0.44 5.8 0.3 1.52e-8 Parkinson's disease; LUSC cis rs1322512 0.917 rs1322510 chr6:152984361 G/C cg27316956 chr6:152958899 SYNE1 0.37 6.28 0.33 1.04e-9 Tonometry; LUSC cis rs4380275 1.000 rs4450634 chr2:773257 G/A cg21665850 chr2:731073 NA 0.42 6.75 0.35 6.49e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs2730245 0.527 rs712197 chr7:158660846 C/G cg24397884 chr7:158709396 WDR60 0.78 8.95 0.44 2.56e-17 Height; LUSC cis rs11785400 1.000 rs13265663 chr8:143732255 A/C cg24634471 chr8:143751801 JRK 0.6 9.09 0.45 8.71e-18 Schizophrenia; LUSC cis rs1983170 0.741 rs6685054 chr1:92018238 T/G cg25838465 chr1:92012736 NA 0.41 5.74 0.3 2.18e-8 Eosinophil percentage of white cells; LUSC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg10523679 chr1:76189770 ACADM 0.86 14.19 0.61 4.34e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg08807101 chr21:30365312 RNF160 -0.7 -12.17 -0.55 1.85e-28 Dental caries; LUSC cis rs17401966 0.540 rs4846199 chr1:10283961 A/G cg19773385 chr1:10388646 KIF1B -0.37 -6.46 -0.33 3.61e-10 Hepatocellular carcinoma; LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC cis rs11229555 0.645 rs11229431 chr11:58181253 A/G cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs752010 0.875 rs11210501 chr1:42091634 T/C cg06885757 chr1:42089581 HIVEP3 0.45 8.98 0.44 2.09e-17 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg21028142 chr17:79581711 NPLOC4 0.35 8.4 0.42 1.26e-15 Eye color traits; LUSC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg11764359 chr7:65958608 NA -0.68 -10.97 -0.51 4.2e-24 Aortic root size; LUSC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg25456477 chr12:86230367 RASSF9 0.43 7.67 0.39 1.9e-13 Major depressive disorder; LUSC cis rs4919687 0.550 rs12780827 chr10:104467954 T/C cg05855489 chr10:104503620 C10orf26 0.71 11.37 0.53 1.53e-25 Colorectal cancer; LUSC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg19729930 chr2:74357872 NA 0.88 16.75 0.68 3.82e-46 Gestational age at birth (maternal effect); LUSC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg22508957 chr16:3507546 NAT15 0.85 10.83 0.51 1.3e-23 Tuberculosis; LUSC cis rs2354432 0.599 rs4950423 chr1:146854539 T/C cg25205988 chr1:146714368 CHD1L 0.84 7.53 0.38 4.92e-13 Mitochondrial DNA levels; LUSC cis rs3749237 1.000 rs1317140 chr3:49878652 G/A cg03060546 chr3:49711283 APEH 0.55 7.39 0.38 1.16e-12 Resting heart rate; LUSC cis rs9457247 0.602 rs6456152 chr6:167472062 A/G cg25258033 chr6:167368657 RNASET2 0.45 6.81 0.35 4.5e-11 Crohn's disease; LUSC cis rs41271473 0.687 rs7535661 chr1:228887667 C/T cg10167378 chr1:228756711 NA 0.48 6.37 0.33 6.1e-10 Chronic lymphocytic leukemia; LUSC cis rs1997103 1.000 rs6977292 chr7:55396335 T/C cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9467773 0.572 rs3846846 chr6:26445039 A/G cg09904177 chr6:26538194 HMGN4 -0.57 -8.72 -0.43 1.3e-16 Intelligence (multi-trait analysis); LUSC cis rs9403521 0.673 rs3934959 chr6:143979710 A/G cg18240653 chr6:144019428 PHACTR2 -0.52 -6.58 -0.34 1.83e-10 Obesity-related traits; LUSC cis rs950169 0.960 rs12905475 chr15:84800495 G/A cg17507749 chr15:85114479 UBE2QP1 0.66 8.1 0.41 1.04e-14 Schizophrenia; LUSC trans rs13011075 0.919 rs17601498 chr2:68611712 A/G cg14221825 chr19:46271408 SIX5 0.42 6.06 0.31 3.74e-9 Mean corpuscular volume; LUSC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg04155289 chr7:94953770 PON1 -0.34 -5.66 -0.3 3.2e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs13392177 0.672 rs4674270 chr2:219053141 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.4 -5.96 -0.31 6.27e-9 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg27398817 chr8:82754497 SNX16 0.66 8.41 0.42 1.18e-15 Diastolic blood pressure; LUSC trans rs1005277 0.505 rs200910 chr10:38108176 C/T cg17830980 chr10:43048298 ZNF37B -0.42 -6.55 -0.34 2.23e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg18252515 chr7:66147081 NA -1.23 -14.54 -0.62 1.89e-37 Gout; LUSC cis rs911119 0.955 rs8121405 chr20:23605226 G/A cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg16145915 chr7:1198662 ZFAND2A -0.72 -15.06 -0.64 1.7e-39 Longevity;Endometriosis; LUSC cis rs662064 0.962 rs2781232 chr1:10544388 T/C cg20482658 chr1:10539492 PEX14 -0.34 -6.89 -0.35 2.8e-11 Asthma; LUSC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg21770322 chr7:97807741 LMTK2 0.42 7.2 0.37 4.05e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs13006833 0.668 rs2582735 chr2:191143798 T/C cg21644426 chr2:191273491 MFSD6 0.47 6.6 0.34 1.61e-10 Urinary metabolites; LUSC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.85 11.06 0.52 1.91e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg20887711 chr4:1340912 KIAA1530 -0.45 -6.9 -0.35 2.56e-11 Obesity-related traits; LUSC cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.36 0.37 1.4e-12 Cognitive ability; LUSC cis rs2197308 0.667 rs61920838 chr12:37856814 T/C cg13010199 chr12:38710504 ALG10B -0.61 -9.45 -0.46 6.34e-19 Morning vs. evening chronotype; LUSC cis rs12908161 0.959 rs61074241 chr15:85333396 C/T cg12863693 chr15:85201151 NMB 0.38 7.27 0.37 2.52e-12 Schizophrenia; LUSC cis rs6982240 0.514 rs10093988 chr8:142260995 T/C cg27411547 chr8:142287226 NA -0.47 -7.9 -0.4 4e-14 Tonsillectomy; LUSC cis rs941873 0.868 rs7898 chr10:81114959 C/T cg11057378 chr10:81107060 PPIF 0.34 5.81 0.3 1.49e-8 Height; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.14 -0.32 2.32e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs60843830 1.000 rs3828165 chr2:220889 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 10.28 0.49 9.82e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs11168618 0.904 rs11495273 chr12:48929190 A/T cg24011408 chr12:48396354 COL2A1 0.39 6.33 0.33 7.83e-10 Adiponectin levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26233468 chr1:155145786 TRIM46;KRTCAP2 -0.43 -6.45 -0.33 3.93e-10 Electrocardiographic conduction measures; LUSC cis rs7520050 0.807 rs4468203 chr1:46113272 T/C cg06784218 chr1:46089804 CCDC17 0.29 5.83 0.3 1.31e-8 Red blood cell count;Reticulocyte count; LUSC cis rs9398803 0.796 rs1361107 chr6:126767511 A/C cg19875578 chr6:126661172 C6orf173 0.43 6.32 0.33 8.59e-10 Male-pattern baldness; LUSC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg01341218 chr17:43662625 NA -0.76 -11.16 -0.52 8.84e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1670533 1.000 rs62879260 chr4:1050850 T/C cg02018176 chr4:1364513 KIAA1530 0.46 6.45 0.33 3.82e-10 Recombination rate (females); LUSC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg14582100 chr15:45693742 SPATA5L1 0.59 10.53 0.5 1.44e-22 Homoarginine levels; LUSC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.01 -0.31 4.94e-9 Huntington's disease progression; LUSC cis rs2267681 0.583 rs764745 chr7:139529928 G/C cg14116596 chr7:139528673 TBXAS1 0.36 6.14 0.32 2.29e-9 Cervical cancer; LUSC cis rs6430585 0.528 rs6711493 chr2:136692553 A/G cg07169764 chr2:136633963 MCM6 1.03 16.16 0.66 8.21e-44 Corneal structure; LUSC cis rs113352275 1 rs113352275 chr15:78840567 C/T cg18825076 chr15:78729989 IREB2 0.44 5.72 0.3 2.31e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg00484396 chr16:3507460 NAT15 -0.47 -7.01 -0.36 1.29e-11 Body mass index (adult); LUSC cis rs977987 0.835 rs8046109 chr16:75360096 A/G cg03315344 chr16:75512273 CHST6 0.51 9.91 0.48 1.78e-20 Dupuytren's disease; LUSC cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.72 -11.65 -0.54 1.51e-26 Colorectal cancer; LUSC trans rs7824557 0.620 rs6996368 chr8:11182704 G/A cg15556689 chr8:8085844 FLJ10661 0.42 6.28 0.32 1.08e-9 Retinal vascular caliber; LUSC cis rs10782582 0.522 rs12125933 chr1:76130920 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.07 -0.36 9.34e-12 Daytime sleep phenotypes; LUSC cis rs6754311 0.773 rs1435576 chr2:136641882 A/T cg07169764 chr2:136633963 MCM6 0.54 7.27 0.37 2.51e-12 Mosquito bite size; LUSC cis rs72960926 0.744 rs72964291 chr6:74891874 C/G cg03266952 chr6:74778945 NA -0.8 -6.32 -0.33 8.53e-10 Metabolite levels (MHPG); LUSC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.846 rs1854901 chr6:146325685 T/C cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 9.26e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs9790314 0.540 rs9844862 chr3:161076188 G/A cg03342759 chr3:160939853 NMD3 -0.4 -5.83 -0.3 1.27e-8 Morning vs. evening chronotype; LUSC cis rs4820539 1.000 rs5759596 chr22:23475750 G/A cg14186256 chr22:23484241 RTDR1 0.95 17.95 0.7 6.57e-51 Bone mineral density; LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.39 0.46 9.37e-19 Bipolar disorder; LUSC cis rs12579753 0.879 rs11115007 chr12:82164673 A/T cg07988820 chr12:82153109 PPFIA2 -0.42 -6.18 -0.32 1.92e-9 Resting heart rate; LUSC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg19622623 chr12:86230825 RASSF9 -0.44 -6.32 -0.33 8.47e-10 Major depressive disorder; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg04234412 chr22:24373322 LOC391322 -0.94 -18.11 -0.7 1.46e-51 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg21770322 chr7:97807741 LMTK2 0.42 7.28 0.37 2.41e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.92 -0.35 2.28e-11 Menopause (age at onset); LUSC trans rs1997103 1.000 rs9649857 chr7:55411777 C/T cg20935933 chr6:143382018 AIG1 0.51 7.43 0.38 8.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg18099408 chr3:52552593 STAB1 0.4 6.38 0.33 5.94e-10 Bipolar disorder; LUSC cis rs2836633 0.929 rs8130434 chr21:40036243 C/T cg05519781 chr21:40033154 ERG -0.78 -13.86 -0.6 8.16e-35 Coronary artery disease; LUSC cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.14 0.45 6.26e-18 Motion sickness; LUSC trans rs7824557 0.591 rs2572452 chr8:11228254 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -7.07 -0.36 9.28e-12 Retinal vascular caliber; LUSC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg11764359 chr7:65958608 NA 0.68 10.85 0.51 1.06e-23 Aortic root size; LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg14004847 chr7:1930337 MAD1L1 -0.46 -6.75 -0.35 6.51e-11 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg17366294 chr4:99064904 C4orf37 0.55 9.57 0.46 2.54e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7264396 0.887 rs224347 chr20:34037523 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.65 -0.34 1.22e-10 Total cholesterol levels; LUSC trans rs12236890 0.561 rs7862467 chr9:3181278 A/C cg14780649 chr1:43534197 NA 0.3 6.37 0.33 6.28e-10 Monobrow thickness; LUSC cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg00074818 chr8:8560427 CLDN23 0.59 9.95 0.48 1.32e-20 Obesity-related traits; LUSC cis rs3820928 0.874 rs6707265 chr2:227849255 T/A cg11843606 chr2:227700838 RHBDD1 -0.55 -8.01 -0.4 1.97e-14 Pulmonary function; LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg20295408 chr7:1910781 MAD1L1 0.42 5.83 0.3 1.33e-8 Bipolar disorder and schizophrenia; LUSC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg09323728 chr8:95962352 TP53INP1 0.35 6.61 0.34 1.53e-10 Type 2 diabetes; LUSC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg04166393 chr7:2884313 GNA12 0.42 5.66 0.3 3.24e-8 Height; LUSC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC trans rs2514895 0.660 rs7925424 chr11:127113326 G/A cg22738642 chr12:43137977 NA 0.5 6.26 0.32 1.17e-9 IgG glycosylation; LUSC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg15445000 chr17:37608096 MED1 0.39 6.68 0.34 9.87e-11 Glomerular filtration rate (creatinine); LUSC cis rs7927592 0.913 rs12284933 chr11:68319489 G/A cg16797656 chr11:68205561 LRP5 0.38 6.23 0.32 1.4e-9 Total body bone mineral density; LUSC cis rs2439831 1.000 rs561863 chr15:43761352 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs7937682 0.814 rs1619652 chr11:111469757 G/A cg09085632 chr11:111637200 PPP2R1B -1.07 -16.85 -0.68 1.49e-46 Primary sclerosing cholangitis; LUSC cis rs10751667 0.666 rs7395267 chr11:962326 C/A ch.11.42038R chr11:967971 AP2A2 0.44 6.6 0.34 1.6e-10 Alzheimer's disease (late onset); LUSC cis rs73198271 0.515 rs74841285 chr8:8635450 C/T cg01851573 chr8:8652454 MFHAS1 0.58 6.53 0.34 2.49e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg05347473 chr6:146136440 FBXO30 -0.5 -8.52 -0.42 5.58e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.23e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs12980942 0.872 rs7257583 chr19:41788117 T/C cg25627403 chr19:41769009 HNRNPUL1 0.58 6.28 0.33 1.03e-9 Coronary artery disease; LUSC cis rs4851254 0.961 rs11680586 chr2:100746207 G/T cg07810366 chr2:100720526 AFF3 -0.36 -5.66 -0.3 3.34e-8 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg12311346 chr5:56204834 C5orf35 -0.88 -12.69 -0.57 2.2e-30 Initial pursuit acceleration; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18825258 chr8:26435354 DPYSL2 0.75 5.96 0.31 6.32e-9 Cognitive performance; LUSC cis rs10782582 0.593 rs12132750 chr1:76136222 A/G cg22875332 chr1:76189707 ACADM -0.42 -6.36 -0.33 6.65e-10 Daytime sleep phenotypes; LUSC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg08704250 chr15:31115839 NA -0.59 -9.2 -0.45 3.95e-18 Huntington's disease progression; LUSC cis rs4478858 0.684 rs7515988 chr1:31731061 C/T cg00250761 chr1:31883323 NA 0.35 8.55 0.42 4.41e-16 Alcohol dependence; LUSC trans rs877282 0.733 rs7092976 chr10:756358 G/A cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11890956 chr21:40555474 PSMG1 -0.85 -14.67 -0.63 5.73e-38 Cognitive function; LUSC cis rs1670533 0.932 rs3796620 chr4:1095079 A/G cg27284194 chr4:1044797 NA -0.56 -8.28 -0.41 2.99e-15 Recombination rate (females); LUSC cis rs1577917 1.000 rs12665321 chr6:86769289 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.77 -0.35 5.91e-11 Response to antipsychotic treatment; LUSC trans rs2243480 1.000 rs313813 chr7:65503500 C/T cg10756647 chr7:56101905 PSPH 0.83 8.12 0.41 9.12e-15 Diabetic kidney disease; LUSC cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg01579765 chr21:45077557 HSF2BP -0.55 -11.5 -0.53 5.15e-26 Mean corpuscular volume; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18516985 chr5:159846223 SLU7 0.79 6.32 0.33 8.37e-10 Cognitive performance; LUSC cis rs4595586 0.545 rs2388176 chr12:39372357 G/A cg26384229 chr12:38710491 ALG10B 0.49 6.99 0.36 1.51e-11 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg21724239 chr8:58056113 NA 0.62 7.28 0.37 2.45e-12 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg10802521 chr3:52805072 NEK4 -0.56 -9.11 -0.45 7.82e-18 Bipolar disorder; LUSC cis rs73206853 0.688 rs60971459 chr12:110702051 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 6.54 0.34 2.31e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9430161 0.645 rs6675082 chr1:11033797 T/C cg02454025 chr1:11042201 C1orf127 1.04 19.33 0.73 2.07e-56 Ewing sarcoma; LUSC cis rs950776 0.714 rs514743 chr15:78884227 A/T cg06917634 chr15:78832804 PSMA4 -0.7 -11.55 -0.53 3.33e-26 Sudden cardiac arrest; LUSC cis rs477692 0.789 rs507900 chr10:131398144 A/G cg11019008 chr10:131425282 MGMT -0.47 -7.07 -0.36 8.86e-12 Response to temozolomide; LUSC cis rs2197308 0.813 rs11504316 chr12:38219320 G/A cg26384229 chr12:38710491 ALG10B -0.59 -8.68 -0.43 1.78e-16 Morning vs. evening chronotype; LUSC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg17971929 chr21:40555470 PSMG1 -0.67 -10.82 -0.51 1.39e-23 Cognitive function; LUSC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.89e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg03676636 chr4:99064102 C4orf37 0.36 7.84 0.39 6.15e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs722599 0.683 rs7142898 chr14:75254310 A/T cg08847533 chr14:75593920 NEK9 0.44 6.18 0.32 1.85e-9 IgG glycosylation; LUSC cis rs9534288 0.742 rs1977395 chr13:46638131 C/T cg15192986 chr13:46630673 CPB2 -0.77 -11.56 -0.53 3.19e-26 Blood protein levels; LUSC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.57 0.34 1.88e-10 Lung cancer; LUSC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.05 0.36 1.02e-11 Schizophrenia; LUSC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg03909863 chr11:638404 DRD4 -0.4 -5.87 -0.31 1.06e-8 Systemic lupus erythematosus; LUSC cis rs1858037 0.867 rs4671660 chr2:65576436 C/A cg08085232 chr2:65598271 SPRED2 -0.4 -5.93 -0.31 7.68e-9 Rheumatoid arthritis; LUSC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg11742103 chr11:62369870 EML3;MTA2 0.49 7.48 0.38 6.71e-13 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs7819412 0.521 rs10110684 chr8:11039159 G/C cg21775007 chr8:11205619 TDH -0.48 -6.54 -0.34 2.3e-10 Triglycerides; LUSC cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC trans rs62103177 0.564 rs2115996 chr18:77701007 C/G cg05926928 chr17:57297772 GDPD1 1.24 15.22 0.64 4.1e-40 Opioid sensitivity; LUSC cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -8.8 -0.43 7.69e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6500395 0.962 rs11648101 chr16:48714178 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.4 0.33 5.13e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3768617 0.510 rs7549768 chr1:183097382 T/G ch.1.3577855R chr1:183094577 LAMC1 0.72 10.95 0.51 4.95e-24 Fuchs's corneal dystrophy; LUSC cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg20503657 chr10:835505 NA 0.89 12.32 0.56 5.37e-29 Eosinophil percentage of granulocytes; LUSC cis rs617219 0.889 rs2121107 chr5:78468004 C/T cg24856658 chr5:78533917 JMY -0.3 -5.75 -0.3 1.98e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg15605315 chr1:45957053 TESK2 -0.42 -6.53 -0.34 2.47e-10 High light scatter reticulocyte count; LUSC cis rs611744 0.870 rs640068 chr8:109158002 A/G cg18478394 chr8:109455254 TTC35 0.4 5.9 0.31 9.12e-9 Dupuytren's disease; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg07167872 chr1:205819463 PM20D1 0.9 17.74 0.7 4.53e-50 Menarche (age at onset); LUSC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg00074818 chr8:8560427 CLDN23 0.59 9.95 0.48 1.35e-20 Obesity-related traits; LUSC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7727544 0.582 rs10052046 chr5:131544466 G/T cg24060327 chr5:131705240 SLC22A5 -0.35 -5.72 -0.3 2.39e-8 Blood metabolite levels; LUSC cis rs757110 0.770 rs4439492 chr11:17386733 C/T cg15432903 chr11:17409602 KCNJ11 0.61 10.83 0.51 1.26e-23 Type 2 diabetes; LUSC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg06022373 chr22:39101656 GTPBP1 0.78 12.16 0.55 2.1e-28 Menopause (age at onset); LUSC cis rs12760731 0.641 rs12038910 chr1:178444907 C/T cg00404053 chr1:178313656 RASAL2 0.58 6.36 0.33 6.6e-10 Obesity-related traits; LUSC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg17366294 chr4:99064904 C4orf37 0.54 8.8 0.43 7.33e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs4631830 0.863 rs2611508 chr10:51518047 T/A cg10326726 chr10:51549505 MSMB -0.35 -5.92 -0.31 8.04e-9 Prostate-specific antigen levels; LUSC cis rs13064411 0.696 rs36054418 chr3:113204762 G/T cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg23583168 chr7:148888333 NA -0.9 -16.84 -0.68 1.65e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.04 -0.36 1.07e-11 Major depressive disorder; LUSC cis rs2859741 0.546 rs2134846 chr1:37500723 G/A cg09363841 chr1:37513479 NA -0.38 -7.15 -0.36 5.35e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs2274459 0.841 rs13204162 chr6:33696131 C/T cg06253072 chr6:33679850 C6orf125 0.5 6.0 0.31 5.28e-9 Obesity (extreme); LUSC cis rs7538876 0.935 rs6586542 chr1:17763566 C/G cg07965774 chr1:17746286 RCC2 -0.3 -5.7 -0.3 2.68e-8 Basal cell carcinoma; LUSC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg07424592 chr7:64974309 NA -0.64 -5.84 -0.3 1.26e-8 Diabetic kidney disease; LUSC cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC cis rs1865760 0.663 rs9348704 chr6:26000393 A/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.78 0.35 5.31e-11 Height; LUSC trans rs12200782 1.000 rs12200782 chr6:26403036 C/G cg11837749 chr1:55047332 ACOT11 0.56 5.99 0.31 5.31e-9 Small cell lung carcinoma; LUSC cis rs116095464 0.558 rs34629844 chr5:200829 A/G cg22857025 chr5:266934 NA -1.18 -13.92 -0.61 4.6e-35 Breast cancer; LUSC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg02034447 chr16:89574710 SPG7 -0.43 -6.57 -0.34 1.93e-10 Multiple myeloma (IgH translocation); LUSC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg00814883 chr7:100076585 TSC22D4 -0.46 -5.68 -0.3 2.89e-8 Lung function (FEV1/FVC); LUSC cis rs4631830 0.695 rs11004584 chr10:51500088 G/T cg16070123 chr10:51489643 NA -0.58 -9.57 -0.46 2.56e-19 Prostate-specific antigen levels; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg07362569 chr17:61921086 SMARCD2 -0.29 -5.78 -0.3 1.73e-8 Prudent dietary pattern; LUSC cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg11244672 chr19:19639970 YJEFN3 -0.58 -7.32 -0.37 1.84e-12 Bipolar disorder; LUSC cis rs6540559 0.546 rs634601 chr1:210421594 C/T cg22029157 chr1:209979665 IRF6 0.57 6.48 0.33 3.21e-10 Cleft lip with or without cleft palate; LUSC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg00815214 chr21:47717953 NA -0.35 -5.72 -0.3 2.33e-8 Testicular germ cell tumor; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg04267008 chr7:1944627 MAD1L1 -0.61 -9.38 -0.46 1.06e-18 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg05585544 chr11:47624801 NA 0.4 7.01 0.36 1.33e-11 Subjective well-being; LUSC cis rs804280 0.509 rs10109241 chr8:11784985 A/T cg00405596 chr8:11794950 NA 0.36 6.0 0.31 5e-9 Myopia (pathological); LUSC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9443189 0.570 rs523465 chr6:76330434 G/C cg01950844 chr6:76311363 SENP6 0.7 7.02 0.36 1.26e-11 Prostate cancer; LUSC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg06494592 chr3:125709126 NA -0.52 -5.93 -0.31 7.44e-9 Blood pressure (smoking interaction); LUSC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Melanoma; LUSC cis rs12801636 0.846 rs1078457 chr11:65380124 C/T cg26668713 chr11:65405903 SIPA1 0.61 6.83 0.35 4.1e-11 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC trans rs11992162 0.551 rs59191504 chr8:11785081 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.64 -0.34 1.27e-10 Monocyte count; LUSC trans rs7819412 0.775 rs4841490 chr8:10936891 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -6.83 -0.35 4.03e-11 Triglycerides; LUSC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03021120 chr16:50402374 BRD7 -0.43 -6.55 -0.34 2.19e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg07701084 chr6:150067640 NUP43 0.58 8.87 0.44 4.56e-17 Lung cancer; LUSC cis rs4494114 1.000 rs4388668 chr1:39360730 A/T cg25970120 chr1:39325951 RRAGC -0.41 -6.36 -0.33 6.61e-10 Blood protein levels; LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg00814883 chr7:100076585 TSC22D4 -0.75 -10.28 -0.49 9.98e-22 Platelet count; LUSC cis rs2346177 0.874 rs35462976 chr2:46649049 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.61 -0.38 2.89e-13 HDL cholesterol; LUSC trans rs1005277 0.579 rs2103938 chr10:38493998 T/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.4 -0.46 9.2e-19 Extrinsic epigenetic age acceleration; LUSC cis rs8060686 0.623 rs6499157 chr16:68105474 A/C cg05110241 chr16:68378359 PRMT7 -0.43 -5.82 -0.3 1.35e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg11871910 chr12:69753446 YEATS4 0.61 8.28 0.41 3.03e-15 Response to diuretic therapy; LUSC cis rs826838 0.935 rs4583043 chr12:38645147 T/G cg13010199 chr12:38710504 ALG10B 0.69 10.75 0.51 2.46e-23 Heart rate; LUSC trans rs853679 0.607 rs56075693 chr6:28290328 T/G cg01620082 chr3:125678407 NA -0.82 -7.65 -0.39 2.2e-13 Depression; LUSC cis rs11031096 0.678 rs10767872 chr11:4184239 T/G cg18678763 chr11:4115507 RRM1 -0.41 -5.85 -0.3 1.2e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2073300 0.609 rs74809795 chr20:23372383 A/C cg12062639 chr20:23401060 NAPB 0.93 8.06 0.4 1.33e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs804280 0.509 rs10109241 chr8:11784985 A/T cg08975724 chr8:8085496 FLJ10661 0.49 7.1 0.36 7.49e-12 Myopia (pathological); LUSC cis rs826838 0.616 rs4418873 chr12:38625473 C/A cg26384229 chr12:38710491 ALG10B 0.59 8.84 0.44 5.5e-17 Heart rate; LUSC cis rs7100689 0.784 rs7895042 chr10:82095276 G/A cg01528321 chr10:82214614 TSPAN14 0.96 14.51 0.62 2.39e-37 Post bronchodilator FEV1; LUSC cis rs7584330 0.518 rs80282956 chr2:238447929 G/A cg14458575 chr2:238380390 NA 0.58 6.82 0.35 4.36e-11 Prostate cancer; LUSC trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg27661571 chr11:113659931 NA 0.58 6.77 0.35 5.78e-11 Hip circumference adjusted for BMI; LUSC cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg02527881 chr3:46936655 PTH1R 0.4 7.11 0.36 6.89e-12 Colorectal cancer; LUSC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.3 -0.33 9.36e-10 Lung cancer; LUSC cis rs2795502 1.000 rs2795502 chr10:43340662 G/A cg20628663 chr10:43360327 NA -0.77 -11.37 -0.53 1.57e-25 Blood protein levels; LUSC trans rs12043259 1.000 rs12410154 chr1:204849156 G/T cg23865240 chr7:27134109 HOXA1 -0.57 -6.01 -0.31 4.87e-9 Addiction; LUSC cis rs1832871 0.672 rs13437296 chr6:158762819 A/C cg07165851 chr6:158734300 TULP4 0.46 6.95 0.36 1.98e-11 Height; LUSC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -13.85 -0.6 8.42e-35 Extrinsic epigenetic age acceleration; LUSC trans rs1941687 0.800 rs1845387 chr18:31358940 T/G cg27147174 chr7:100797783 AP1S1 -0.47 -6.97 -0.36 1.66e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2652834 0.904 rs2729826 chr15:63360446 C/G cg05507819 chr15:63340323 TPM1 -0.68 -8.73 -0.43 1.23e-16 HDL cholesterol; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg12963246 chr6:28129442 ZNF389 0.59 8.18 0.41 6.19e-15 Parkinson's disease; LUSC cis rs7267979 1.000 rs6115159 chr20:25350944 T/C cg03522245 chr20:25566470 NINL -0.35 -5.68 -0.3 2.89e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg02175503 chr12:58329896 NA 0.66 10.82 0.51 1.33e-23 Intelligence (multi-trait analysis); LUSC cis rs9403521 0.673 rs7748882 chr6:143991712 T/C cg18240653 chr6:144019428 PHACTR2 -0.52 -6.83 -0.35 3.91e-11 Obesity-related traits; LUSC cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 3.09e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9372253 0.967 rs1055301 chr6:110713042 A/G cg19196401 chr6:110721138 DDO -0.42 -7.75 -0.39 1.12e-13 Platelet distribution width; LUSC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs1003719 0.788 rs3787783 chr21:38462959 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg04511125 chr2:88470314 THNSL2 0.96 9.14 0.45 6.02e-18 Plasma clusterin levels; LUSC cis rs4356932 1.000 rs6820370 chr4:76952278 G/A cg00809888 chr4:76862425 NAAA 0.35 5.77 0.3 1.78e-8 Blood protein levels; LUSC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg20476274 chr7:133979776 SLC35B4 0.87 16.89 0.68 1.02e-46 Mean platelet volume; LUSC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg22535103 chr8:58192502 C8orf71 -0.79 -9.6 -0.46 2.04e-19 Developmental language disorder (linguistic errors); LUSC cis rs34779708 0.931 rs35886556 chr10:35334985 C/T cg03585969 chr10:35415529 CREM 0.61 8.82 0.43 6.41e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg13010199 chr12:38710504 ALG10B 0.57 8.6 0.43 3.06e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs11227306 0.934 rs7102454 chr11:65594820 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.39 -6.59 -0.34 1.71e-10 DNA methylation (variation); LUSC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg23649088 chr2:200775458 C2orf69 0.55 7.38 0.37 1.26e-12 Schizophrenia; LUSC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Tonsillectomy; LUSC cis rs7588746 0.571 rs10931896 chr2:201148076 C/T cg23649088 chr2:200775458 C2orf69 -0.41 -5.85 -0.31 1.14e-8 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs977987 0.806 rs72787160 chr16:75445162 G/C cg03315344 chr16:75512273 CHST6 0.48 8.96 0.44 2.4e-17 Dupuytren's disease; LUSC trans rs2243480 1.000 rs67728539 chr7:65378124 G/A cg10756647 chr7:56101905 PSPH 0.87 8.37 0.42 1.6e-15 Diabetic kidney disease; LUSC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg07741184 chr6:167504864 NA 0.4 7.13 0.36 6.37e-12 Crohn's disease; LUSC cis rs4604732 0.527 rs12031949 chr1:247624463 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.43 6.33 0.33 7.95e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg01689657 chr7:91764605 CYP51A1 0.33 6.03 0.31 4.29e-9 Breast cancer; LUSC cis rs1595825 1.000 rs1595825 chr2:198875464 G/A cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs1395 0.778 rs12465084 chr2:27414203 G/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.26 0.37 2.73e-12 Blood metabolite levels; LUSC cis rs1003719 0.679 rs2835638 chr21:38534533 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.56e-22 Eye color traits; LUSC cis rs7552167 0.789 rs6424162 chr1:24512576 T/C cg01960748 chr1:24522592 NA -0.69 -10.22 -0.49 1.63e-21 Psoriasis vulgaris; LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.23 0.37 3.42e-12 Bipolar disorder; LUSC trans rs9650657 0.538 rs6984496 chr8:10796093 G/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.7 -0.39 1.54e-13 Neuroticism; LUSC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg05347473 chr6:146136440 FBXO30 0.62 10.47 0.5 2.25e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.19 0.64 5.67e-40 Bladder cancer; LUSC cis rs17407555 0.606 rs3775945 chr4:10011996 A/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.22 -0.32 1.5e-9 Schizophrenia (age at onset); LUSC cis rs1461503 0.966 rs7110154 chr11:122843300 A/G cg27398637 chr11:122830231 C11orf63 -0.4 -6.5 -0.34 2.93e-10 Menarche (age at onset); LUSC cis rs7917772 0.582 rs10883753 chr10:104372441 C/T cg05855489 chr10:104503620 C10orf26 -0.49 -7.38 -0.37 1.27e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1577917 1.000 rs10944163 chr6:86658693 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.25e-17 Response to antipsychotic treatment; LUSC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg03806693 chr22:41940476 POLR3H 0.99 13.79 0.6 1.53e-34 Vitiligo; LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg07148914 chr20:33460835 GGT7 0.55 8.59 0.43 3.32e-16 Height; LUSC cis rs16866061 1.000 rs4674916 chr2:225365635 C/A cg12698349 chr2:225449008 CUL3 0.86 13.75 0.6 2.06e-34 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg01657329 chr11:68192670 LRP5 0.46 7.38 0.37 1.26e-12 Total body bone mineral density; LUSC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg23630131 chr7:65973040 NA 0.21 5.73 0.3 2.25e-8 Aortic root size; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg21176326 chr7:148788010 ZNF786 0.41 6.23 0.32 1.38e-9 N-glycan levels; LUSC cis rs314370 0.570 rs314324 chr7:100433794 C/T cg10426581 chr7:100472382 SRRT 0.49 7.63 0.39 2.44e-13 Resting heart rate; LUSC cis rs9814567 0.752 rs1880378 chr3:134330709 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg20891283 chr12:69753455 YEATS4 0.65 9.58 0.46 2.35e-19 Cerebrospinal fluid biomarker levels; LUSC trans rs9929218 0.954 rs12924033 chr16:68822599 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -11.08 -0.52 1.63e-24 Colorectal cancer; LUSC cis rs34779708 0.702 rs35969476 chr10:35544318 G/A cg03585969 chr10:35415529 CREM 0.56 7.79 0.39 8.66e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs36405 0.500 rs8011906 chr14:72359795 C/G cg23396177 chr14:72358413 NA -0.35 -6.65 -0.34 1.2e-10 Yang-deficiency constitution; LUSC cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg23788917 chr6:8435910 SLC35B3 0.51 7.48 0.38 6.83e-13 Motion sickness; LUSC cis rs600231 0.665 rs1616810 chr11:65220105 A/G cg21890820 chr11:65308645 LTBP3 0.47 7.1 0.36 7.78e-12 Bone mineral density; LUSC cis rs7178572 0.743 rs62009090 chr15:77837055 T/G cg22256960 chr15:77711686 NA -0.46 -7.23 -0.37 3.32e-12 Type 2 diabetes; LUSC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg07636037 chr3:49044803 WDR6 0.43 6.26 0.32 1.21e-9 Resting heart rate; LUSC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.09 0.4 1.15e-14 Axial length; LUSC cis rs2625529 0.652 rs2929513 chr15:72229180 G/A cg16672083 chr15:72433130 SENP8 0.5 8.28 0.41 2.95e-15 Red blood cell count; LUSC trans rs61931739 0.500 rs9669027 chr12:34583528 C/T cg26384229 chr12:38710491 ALG10B -0.79 -13.28 -0.59 1.33e-32 Morning vs. evening chronotype; LUSC cis rs8063160 0.756 rs71396951 chr16:89726593 G/C cg07984980 chr16:89898383 SPIRE2 0.87 6.78 0.35 5.44e-11 Red vs non-red hair color;Light vs. dark hair color;Brown vs. non-brown hair color; LUSC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg11214544 chr1:2391121 NA -0.36 -6.08 -0.32 3.29e-9 Schizophrenia; LUSC cis rs10465746 0.905 rs1324484 chr1:84382844 T/C cg10977910 chr1:84465055 TTLL7 0.42 6.08 0.32 3.29e-9 Obesity-related traits; LUSC cis rs11098499 0.866 rs13125526 chr4:120288019 G/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg17366294 chr4:99064904 C4orf37 0.52 9.2 0.45 3.87e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs3806843 0.966 rs1030163 chr5:140185132 G/A cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg13175981 chr1:150552382 MCL1 0.4 5.7 0.3 2.57e-8 Tonsillectomy; LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg16606324 chr3:10149918 C3orf24 0.65 9.65 0.47 1.38e-19 Alzheimer's disease; LUSC cis rs3818285 0.959 rs3740137 chr10:111630917 G/A cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.92 -0.4 3.55e-14 Superior crus of antihelix expression; LUSC cis rs6456156 0.524 rs6934043 chr6:167466449 C/T cg07741184 chr6:167504864 NA 0.39 6.92 0.35 2.27e-11 Primary biliary cholangitis; LUSC trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs7561273 0.609 rs2080727 chr2:24350907 A/G cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC cis rs10435719 0.867 rs6999030 chr8:11795308 G/A cg21775007 chr8:11205619 TDH 0.47 6.69 0.34 9.25e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs8014204 0.533 rs12889955 chr14:75172999 G/A cg06637938 chr14:75390232 RPS6KL1 0.53 8.28 0.41 3.1e-15 Caffeine consumption; LUSC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg11941060 chr3:133502564 NA -0.63 -9.85 -0.47 2.84e-20 Iron status biomarkers; LUSC cis rs4356932 0.691 rs4282209 chr4:76919536 A/G cg00809888 chr4:76862425 NAAA 0.36 5.74 0.3 2.13e-8 Blood protein levels; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg04518342 chr5:131593106 PDLIM4 0.41 7.89 0.4 4.4e-14 Blood metabolite levels; LUSC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg20503657 chr10:835505 NA 0.84 11.33 0.53 2.16e-25 Eosinophil percentage of granulocytes; LUSC cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.14 -0.41 7.7e-15 Bone mineral density; LUSC trans rs4332037 1.000 rs62442899 chr7:1948454 C/T cg25206134 chr2:45395956 NA 0.56 6.44 0.33 4.13e-10 Bipolar disorder; LUSC cis rs61931739 0.517 rs2101396 chr12:34048927 T/A cg06521331 chr12:34319734 NA -0.49 -8.13 -0.41 8.54e-15 Morning vs. evening chronotype; LUSC cis rs10782582 0.593 rs11163915 chr1:76130199 C/T cg03433033 chr1:76189801 ACADM -0.45 -6.87 -0.35 3.12e-11 Daytime sleep phenotypes; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg10881360 chr1:24069720 TCEB3 0.49 5.95 0.31 6.61e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1832871 0.965 rs10945541 chr6:158740218 A/G cg07165851 chr6:158734300 TULP4 -0.34 -5.83 -0.3 1.3e-8 Height; LUSC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg12311346 chr5:56204834 C5orf35 -0.86 -12.09 -0.55 3.81e-28 Initial pursuit acceleration; LUSC trans rs12043259 1.000 rs12239873 chr1:204825808 C/G cg23865240 chr7:27134109 HOXA1 -0.53 -6.01 -0.31 4.8e-9 Addiction; LUSC cis rs7072216 0.727 rs7915108 chr10:100164441 T/C cg26618903 chr10:100175079 PYROXD2 -0.46 -8.44 -0.42 1e-15 Metabolite levels; LUSC trans rs7618501 0.633 rs3774733 chr3:50037123 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 9.04 0.44 1.26e-17 Intelligence (multi-trait analysis); LUSC cis rs7793919 0.652 rs10228886 chr7:4783224 C/T cg00064840 chr7:4784485 FOXK1 -0.3 -5.91 -0.31 8.46e-9 Mosquito bite size; LUSC cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg18876405 chr7:65276391 NA 0.55 8.65 0.43 2.22e-16 Aortic root size; LUSC cis rs6546886 0.912 rs10200470 chr2:74284687 A/G cg14702570 chr2:74259524 NA -0.31 -5.77 -0.3 1.8e-8 Dialysis-related mortality; LUSC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg17554472 chr22:41940697 POLR3H -0.47 -5.75 -0.3 2.03e-8 Vitiligo; LUSC cis rs12478296 1.000 rs57603292 chr2:243028537 G/A cg06360820 chr2:242988706 NA -0.93 -10.14 -0.49 3.12e-21 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14497545 chr4:140754475 MAML3 -0.42 -7.43 -0.38 9e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7618501 0.633 rs11925192 chr3:50038664 G/A cg21659725 chr3:3221576 CRBN 0.63 10.4 0.49 3.93e-22 Intelligence (multi-trait analysis); LUSC cis rs10892173 0.566 rs2298649 chr11:117672225 A/G cg07621104 chr11:117668040 DSCAML1 0.49 6.36 0.33 6.76e-10 Myopia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19782173 chr5:76383047 LOC728723;ZBED3 0.51 7.18 0.37 4.56e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs611744 0.550 rs1448154 chr8:109281053 T/C cg21045802 chr8:109455806 TTC35 0.42 6.58 0.34 1.79e-10 Dupuytren's disease; LUSC cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg11645453 chr3:52864694 ITIH4 0.34 7.99 0.4 2.15e-14 Intelligence (multi-trait analysis); LUSC cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 8.87 0.44 4.45e-17 Menarche (age at onset); LUSC trans rs1493916 0.905 rs9956315 chr18:31405546 G/C cg15819921 chr19:927150 ARID3A -0.42 -6.38 -0.33 5.85e-10 Life satisfaction; LUSC cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg16797656 chr11:68205561 LRP5 0.36 5.97 0.31 5.96e-9 Total body bone mineral density; LUSC cis rs17253792 0.822 rs75399477 chr14:56174413 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.9 -0.35 2.66e-11 Putamen volume; LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg03354898 chr7:1950403 MAD1L1 -0.32 -6.3 -0.33 9.32e-10 Bipolar disorder and schizophrenia; LUSC trans rs629535 0.814 rs604254 chr8:70059164 A/G cg21567404 chr3:27674614 NA 0.97 15.38 0.64 9.67e-41 Dupuytren's disease; LUSC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg18404041 chr3:52824283 ITIH1 0.4 7.2 0.37 3.96e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs17270561 0.779 rs78589800 chr6:25883500 C/G cg17042849 chr6:26104293 HIST1H4C -0.47 -5.87 -0.31 1.05e-8 Iron status biomarkers; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg16145915 chr7:1198662 ZFAND2A -0.54 -10.18 -0.49 2.29e-21 Longevity;Endometriosis; LUSC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg02782426 chr3:40428986 ENTPD3 0.42 7.95 0.4 2.87e-14 Renal cell carcinoma; LUSC cis rs17270561 0.609 rs1318016 chr6:25764704 A/T cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs6831352 0.879 rs35146617 chr4:100066686 C/T cg12011299 chr4:100065546 ADH4 -0.73 -10.43 -0.5 3.05e-22 Alcohol dependence; LUSC trans rs877282 0.853 rs12777155 chr10:754731 G/C cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs7582720 1.000 rs72932781 chr2:203697278 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9929218 0.551 rs9888942 chr16:68727572 A/G cg01251360 chr16:68772225 CDH1 -0.28 -6.53 -0.34 2.51e-10 Colorectal cancer; LUSC cis rs523522 0.962 rs687873 chr12:121019634 G/A cg27279351 chr12:120934652 DYNLL1 0.66 8.97 0.44 2.22e-17 High light scatter reticulocyte count; LUSC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg11941060 chr3:133502564 NA -0.51 -7.92 -0.4 3.5e-14 Iron status biomarkers; LUSC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg19077165 chr18:44547161 KATNAL2 -0.4 -5.76 -0.3 1.89e-8 Personality dimensions; LUSC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg14440974 chr22:39074834 NA -0.35 -5.86 -0.31 1.11e-8 Menopause (age at onset); LUSC cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg26408565 chr15:76604113 ETFA -0.45 -7.01 -0.36 1.29e-11 Blood metabolite levels; LUSC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg20790798 chr5:1857306 NA -0.48 -8.28 -0.41 3.05e-15 Cardiovascular disease risk factors; LUSC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg05313129 chr8:58192883 C8orf71 -0.51 -6.52 -0.34 2.54e-10 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14082963 chr4:89444434 PIGY 0.39 6.57 0.34 1.92e-10 Triglycerides; LUSC cis rs73206853 0.764 rs7312139 chr12:110985442 C/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.26 0.37 2.76e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg17340268 chr14:105411764 AHNAK2 -0.41 -6.48 -0.33 3.36e-10 Rheumatoid arthritis; LUSC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg01017244 chr2:74357527 NA 0.69 13.33 0.59 8.68e-33 Gestational age at birth (maternal effect); LUSC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg08917208 chr2:24149416 ATAD2B 0.53 5.88 0.31 1e-8 Lymphocyte counts; LUSC cis rs6138458 1.000 rs227618 chr20:24909472 T/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.93 -0.35 2.21e-11 Blood protein levels; LUSC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg18904891 chr8:8559673 CLDN23 0.57 8.28 0.41 3.06e-15 Obesity-related traits; LUSC trans rs1973993 0.689 rs67544133 chr1:96971241 G/A cg10631902 chr5:14652156 NA -0.43 -6.23 -0.32 1.41e-9 Weight; LUSC trans rs12200782 1.000 rs6456741 chr6:26617058 C/T cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg14159672 chr1:205819179 PM20D1 0.89 16.3 0.67 2.43e-44 Menarche (age at onset); LUSC trans rs2694917 0.680 rs2638314 chr12:56866334 T/A cg19051015 chr17:46697414 NA 0.4 6.14 0.32 2.34e-9 Blood metabolite ratios; LUSC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC cis rs2625529 0.878 rs4777478 chr15:72279085 T/C cg16672083 chr15:72433130 SENP8 -0.51 -7.37 -0.37 1.34e-12 Red blood cell count; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.17 0.52 7.97e-25 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg17366294 chr4:99064904 C4orf37 0.6 10.6 0.5 8.12e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.51 7.54 0.38 4.55e-13 Schizophrenia; LUSC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.29 -0.33 1.02e-9 Life satisfaction; LUSC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -11.93 -0.55 1.42e-27 Mean corpuscular volume; LUSC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg06022373 chr22:39101656 GTPBP1 0.84 14.02 0.61 1.86e-35 Menopause (age at onset); LUSC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg04511125 chr2:88470314 THNSL2 -0.96 -9.14 -0.45 6.02e-18 Plasma clusterin levels; LUSC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg06022373 chr22:39101656 GTPBP1 0.78 12.23 0.56 1.11e-28 Menopause (age at onset); LUSC cis rs7605827 0.930 rs4668447 chr2:15516166 T/C cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.71e-17 Educational attainment (years of education); LUSC cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs67072384 0.901 rs2886366 chr11:72455207 G/C cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs354225 0.544 rs10187447 chr2:54806711 A/T cg01766943 chr2:54829624 SPTBN1 0.49 7.94 0.4 3.16e-14 Schizophrenia; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg27566289 chr17:48133890 ITGA3 0.39 6.11 0.32 2.82e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs13126513 0.519 rs959247 chr4:100556984 A/G cg05468953 chr4:100565104 NA 0.36 6.91 0.35 2.5e-11 Metabolite levels (MHPG); LUSC cis rs1044826 1.000 rs9835241 chr3:139234555 A/G cg00490450 chr3:139108681 COPB2 0.52 6.72 0.34 8.03e-11 Obesity-related traits; LUSC cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg20406979 chr6:167373233 NA -0.25 -5.66 -0.3 3.2e-8 Crohn's disease; LUSC cis rs10751667 0.600 rs11246376 chr11:999622 C/T cg01483505 chr11:975446 AP2A2 0.4 5.67 0.3 3.08e-8 Alzheimer's disease (late onset); LUSC cis rs9300255 0.679 rs12829456 chr12:123725395 C/T cg00376283 chr12:123451042 ABCB9 -0.69 -7.78 -0.39 9.37e-14 Neutrophil percentage of white cells; LUSC cis rs12579753 0.833 rs12579530 chr12:82163930 A/C cg07988820 chr12:82153109 PPFIA2 -0.41 -6.09 -0.32 3.1e-9 Resting heart rate; LUSC cis rs10876993 0.890 rs1689584 chr12:58081478 G/A cg15848620 chr12:58087721 OS9 -0.57 -8.18 -0.41 6.1e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg13453750 chr1:205783389 SLC41A1 -0.33 -6.41 -0.33 5.09e-10 Menarche (age at onset); LUSC cis rs926938 0.505 rs2878573 chr1:115521602 A/G cg01522456 chr1:115632236 TSPAN2 -0.41 -6.41 -0.33 5.05e-10 Autism; LUSC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg11062466 chr8:58055876 NA 0.51 6.61 0.34 1.51e-10 Developmental language disorder (linguistic errors); LUSC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg00784671 chr22:46762841 CELSR1 -0.54 -6.79 -0.35 5.18e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs10392 0.516 rs4141892 chr20:37590758 T/C cg27552599 chr20:37590471 DHX35 0.45 7.36 0.37 1.4e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs1957429 0.614 rs117722345 chr14:65381464 C/G cg23373153 chr14:65346875 NA -0.98 -7.73 -0.39 1.3e-13 Pediatric areal bone mineral density (radius); LUSC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg02782426 chr3:40428986 ENTPD3 0.35 6.55 0.34 2.2e-10 Renal cell carcinoma; LUSC cis rs3862030 0.720 rs11595149 chr10:104235978 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.95 -0.44 2.46e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7903847 0.642 rs6584128 chr10:99171926 G/T cg08345082 chr10:99160200 RRP12 0.37 7.56 0.38 4.03e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.67 -0.39 1.89e-13 Blood metabolite levels; LUSC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg19230755 chr7:65878503 NA -0.42 -5.88 -0.31 1.01e-8 Aortic root size; LUSC cis rs3845702 0.736 rs72958863 chr2:180808144 C/T cg01881094 chr2:180872142 CWC22 1.06 12.67 0.57 2.59e-30 Schizophrenia; LUSC cis rs921968 0.542 rs588182 chr2:219412335 C/A cg02176678 chr2:219576539 TTLL4 0.74 14.68 0.63 5.59e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs1609391 0.543 rs9828009 chr3:136631275 C/T cg15507776 chr3:136538369 TMEM22 0.51 8.36 0.42 1.71e-15 Neuroticism; LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18099408 chr3:52552593 STAB1 -0.38 -6.78 -0.35 5.55e-11 Electroencephalogram traits; LUSC cis rs977987 0.806 rs35263058 chr16:75391937 T/C cg03315344 chr16:75512273 CHST6 0.5 9.59 0.46 2.19e-19 Dupuytren's disease; LUSC cis rs9399135 0.967 rs2297340 chr6:135376058 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.09 0.45 9.11e-18 Red blood cell count; LUSC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg25554036 chr4:6271136 WFS1 0.61 12.65 0.57 3.12e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs7618501 0.633 rs2624843 chr3:49997963 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.55 8.81 0.43 6.94e-17 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.41 -6.76 -0.35 6.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7804356 1.000 rs3823930 chr7:26856525 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs7177699 0.557 rs4073322 chr15:79122541 G/C cg15571903 chr15:79123663 NA 0.35 6.39 0.33 5.42e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg21856205 chr7:94953877 PON1 -0.35 -5.65 -0.3 3.44e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6845621 0.901 rs207293 chr4:18919345 G/C cg12196642 chr4:18937545 NA -0.34 -6.36 -0.33 6.61e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9653442 0.593 rs2309811 chr2:100862359 A/G cg22139774 chr2:100720529 AFF3 -0.4 -6.6 -0.34 1.64e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2692947 0.740 rs4907280 chr2:96402126 A/G cg23100626 chr2:96804247 ASTL 0.29 6.83 0.35 3.97e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9875589 0.509 rs1601870 chr3:14024162 T/C cg19554555 chr3:13937349 NA -0.39 -5.91 -0.31 8.62e-9 Ovarian reserve; LUSC cis rs9902453 0.715 rs2628176 chr17:28139292 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -9.96 -0.48 1.28e-20 Coffee consumption (cups per day); LUSC cis rs4268898 0.722 rs34565113 chr2:24423076 G/T cg06627628 chr2:24431161 ITSN2 0.6 8.36 0.42 1.77e-15 Asthma; LUSC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.8 -0.35 4.8e-11 Alzheimer's disease (late onset); LUSC cis rs2067615 0.560 rs10431462 chr12:107106546 G/A cg15890332 chr12:107067104 RFX4 0.33 6.02 0.31 4.66e-9 Heart rate; LUSC cis rs6430585 0.583 rs12373779 chr2:136586840 A/C cg07169764 chr2:136633963 MCM6 1.15 17.44 0.69 6.87e-49 Corneal structure; LUSC cis rs4808199 0.948 rs968525 chr19:19459215 C/T cg03709012 chr19:19516395 GATAD2A 0.94 11.64 0.54 1.65e-26 Nonalcoholic fatty liver disease; LUSC cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg26897989 chr16:1907736 C16orf73 -0.38 -6.25 -0.32 1.26e-9 Glomerular filtration rate in chronic kidney disease; LUSC trans rs1728785 1.000 rs698716 chr16:68560296 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.71 0.39 1.46e-13 Ulcerative colitis; LUSC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg24250549 chr1:154909240 PMVK 0.64 10.73 0.51 2.82e-23 Prostate cancer; LUSC cis rs2777491 0.789 rs316617 chr15:41795900 C/T cg18705301 chr15:41695430 NDUFAF1 0.63 11.1 0.52 1.43e-24 Ulcerative colitis; LUSC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg18099408 chr3:52552593 STAB1 0.38 6.68 0.34 9.94e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg24642439 chr20:33292090 TP53INP2 0.53 8.13 0.41 8.37e-15 Coronary artery disease; LUSC cis rs1003719 0.680 rs2835630 chr21:38521842 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.35 -0.49 5.87e-22 Eye color traits; LUSC cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs9341808 0.718 rs9343971 chr6:80882056 C/T cg08355045 chr6:80787529 NA 0.58 10.07 0.48 5.33e-21 Sitting height ratio; LUSC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.42 0.42 1.16e-15 Tonsillectomy; LUSC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg06212747 chr3:49208901 KLHDC8B 0.44 6.05 0.31 3.95e-9 Parkinson's disease; LUSC cis rs2479724 0.818 rs9357369 chr6:41818202 A/C cg17623882 chr6:41773611 USP49 -0.62 -10.52 -0.5 1.58e-22 Menarche (age at onset); LUSC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg22907277 chr7:1156413 C7orf50 0.63 7.0 0.36 1.38e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.83 -0.35 4.11e-11 Crohn's disease; LUSC cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs11971779 0.680 rs11768023 chr7:139054395 T/A cg07862535 chr7:139043722 LUC7L2 0.59 7.63 0.39 2.51e-13 Diisocyanate-induced asthma; LUSC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg03233332 chr7:66118400 NA -0.42 -6.1 -0.32 2.88e-9 Aortic root size; LUSC cis rs981844 0.775 rs62323977 chr4:154746141 G/A cg14289246 chr4:154710475 SFRP2 0.47 6.21 0.32 1.59e-9 Response to statins (LDL cholesterol change); LUSC cis rs4888262 0.564 rs8050850 chr16:74582597 C/A cg01733217 chr16:74700730 RFWD3 0.75 12.29 0.56 6.92e-29 Testicular germ cell tumor; LUSC cis rs3824867 0.881 rs4752829 chr11:47396654 G/A cg20307385 chr11:47447363 PSMC3 -0.65 -9.13 -0.45 6.79e-18 Mean corpuscular hemoglobin; LUSC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs9323205 0.723 rs61987304 chr14:51741213 A/G cg23942311 chr14:51606299 NA -0.42 -7.91 -0.4 3.73e-14 Cancer; LUSC cis rs7809950 1.000 rs3801948 chr7:107238447 A/T cg23024343 chr7:107201750 COG5 -0.55 -8.64 -0.43 2.39e-16 Coronary artery disease; LUSC cis rs8017423 0.647 rs4904677 chr14:90819245 C/T cg04374321 chr14:90722782 PSMC1 -0.44 -6.64 -0.34 1.26e-10 Mortality in heart failure; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.69 10.86 0.51 9.73e-24 Prudent dietary pattern; LUSC cis rs243505 0.898 rs243524 chr7:148418181 A/C cg09806900 chr7:148480153 CUL1 -0.44 -6.39 -0.33 5.65e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6669072 0.679 rs3896732 chr1:91313672 A/G cg08895590 chr1:91227319 NA 0.32 6.92 0.35 2.37e-11 Cognitive function; LUSC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg26769984 chr7:1090371 C7orf50 0.56 7.43 0.38 9.3e-13 Bronchopulmonary dysplasia; LUSC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg03929089 chr4:120376271 NA -0.94 -16.25 -0.66 3.8e-44 Height; LUSC trans rs9650657 0.504 rs10093053 chr8:11037187 T/C cg08975724 chr8:8085496 FLJ10661 -0.45 -6.41 -0.33 4.95e-10 Neuroticism; LUSC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg06740227 chr12:86229804 RASSF9 0.39 6.15 0.32 2.22e-9 Major depressive disorder; LUSC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg00310523 chr12:86230176 RASSF9 0.54 10.06 0.48 5.63e-21 Major depressive disorder; LUSC cis rs6977660 1.000 rs12531373 chr7:19816825 A/C cg05791153 chr7:19748676 TWISTNB 0.54 6.06 0.31 3.66e-9 Thyroid stimulating hormone; LUSC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg06238570 chr21:40685208 BRWD1 -0.62 -10.5 -0.5 1.74e-22 Cognitive function; LUSC cis rs3020736 0.500 rs7292241 chr22:42492063 G/A cg05082376 chr22:42548792 NA 0.42 6.21 0.32 1.58e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04324509 chr3:101295624 PCNP 0.49 6.2 0.32 1.68e-9 Bipolar disorder and schizophrenia; LUSC cis rs8067354 0.645 rs2645467 chr17:57854783 C/T cg02344993 chr17:57696989 CLTC 0.49 7.29 0.37 2.3e-12 Hemoglobin concentration; LUSC cis rs314370 0.904 rs314373 chr7:100456595 G/A cg18683606 chr7:100471612 SRRT 0.44 5.87 0.31 1.07e-8 Resting heart rate; LUSC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.99 -0.48 9.62e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs6690583 0.573 rs75119114 chr1:85451385 A/C cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 1.99e-10 Serum sulfate level; LUSC cis rs62400317 0.762 rs62436369 chr6:44867539 C/G cg18551225 chr6:44695536 NA -0.46 -7.44 -0.38 8.7e-13 Total body bone mineral density; LUSC cis rs2404602 0.647 rs12910081 chr15:77022959 G/C cg23625390 chr15:77176239 SCAPER -0.65 -9.87 -0.48 2.56e-20 Blood metabolite levels; LUSC cis rs1670533 1.000 rs6836350 chr4:1069973 C/T cg27284194 chr4:1044797 NA 0.58 8.93 0.44 2.81e-17 Recombination rate (females); LUSC cis rs6696846 0.765 rs11577406 chr1:205065733 G/T cg21545522 chr1:205238299 TMCC2 0.47 8.76 0.43 9.86e-17 Red blood cell count; LUSC cis rs11098499 0.908 rs28559989 chr4:120386627 C/T cg24375607 chr4:120327624 NA 0.78 11.54 0.53 3.88e-26 Corneal astigmatism; LUSC cis rs9311676 0.656 rs62258134 chr3:58398447 C/T cg13750441 chr3:58318267 PXK 0.35 6.68 0.34 1.02e-10 Systemic lupus erythematosus; LUSC cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg24060327 chr5:131705240 SLC22A5 0.48 8.18 0.41 5.94e-15 Blood metabolite levels; LUSC cis rs2901656 0.677 rs1063412 chr1:172410967 G/A cg03748243 chr1:172413542 C1orf105;PIGC 0.39 8.15 0.41 7.53e-15 Red cell distribution width;Platelet distribution width; LUSC cis rs6456156 0.586 rs13210649 chr6:167473193 T/G cg25258033 chr6:167368657 RNASET2 0.37 5.76 0.3 1.91e-8 Primary biliary cholangitis; LUSC cis rs7640424 0.721 rs162064 chr3:107824061 G/T cg09227934 chr3:107805635 CD47 -0.38 -6.0 -0.31 5.15e-9 Body mass index; LUSC cis rs8114671 0.562 rs959829 chr20:33346047 T/C cg07148914 chr20:33460835 GGT7 -0.58 -8.8 -0.43 7.21e-17 Height; LUSC cis rs12476592 0.714 rs262492 chr2:63844685 G/A cg10828910 chr2:63850056 LOC388955 0.54 6.39 0.33 5.58e-10 Childhood ear infection; LUSC cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg20283391 chr11:68216788 NA -0.56 -7.9 -0.4 4.18e-14 Total body bone mineral density; LUSC cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.09e-22 Glomerular filtration rate (creatinine); LUSC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg03433033 chr1:76189801 ACADM -0.49 -7.5 -0.38 5.97e-13 Daytime sleep phenotypes; LUSC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.83 9.64 0.47 1.47e-19 Mean platelet volume; LUSC cis rs17608059 0.710 rs8080167 chr17:13949828 G/A cg11395062 chr17:14139857 CDRT15 0.4 6.04 0.31 4.01e-9 Temperament; LUSC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg08677398 chr8:58056175 NA 0.54 7.38 0.37 1.24e-12 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.74 0.84 1.09e-88 Chronic sinus infection; LUSC cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg22535103 chr8:58192502 C8orf71 -0.78 -7.97 -0.4 2.62e-14 Developmental language disorder (linguistic errors); LUSC cis rs13082711 0.911 rs13077400 chr3:27473066 A/G cg02860705 chr3:27208620 NA 0.44 7.28 0.37 2.34e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs73206853 0.764 rs73206868 chr12:110816835 G/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs11098499 0.663 rs28369503 chr4:120238925 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.3 0.33 9.58e-10 Corneal astigmatism; LUSC cis rs7512552 0.839 rs2647373 chr1:150320570 G/C cg15654264 chr1:150340011 RPRD2 0.69 11.59 0.54 2.51e-26 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg08048268 chr3:133502702 NA -0.48 -9.29 -0.45 2.11e-18 Iron status biomarkers; LUSC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg06022373 chr22:39101656 GTPBP1 0.76 11.93 0.55 1.43e-27 Menopause (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11227645 chr1:224544764 CNIH4 -0.49 -6.73 -0.35 7.49e-11 Bipolar disorder and schizophrenia; LUSC cis rs10754283 0.934 rs6684676 chr1:90102173 C/T cg21401794 chr1:90099060 LRRC8C 0.65 9.79 0.47 4.51e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg08439880 chr3:133502540 NA -0.38 -6.95 -0.36 1.97e-11 Iron status biomarkers; LUSC cis rs1538970 0.924 rs7528573 chr1:45913860 T/C cg05343316 chr1:45956843 TESK2 0.66 9.01 0.44 1.62e-17 Platelet count; LUSC cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.51 5.76 0.3 1.93e-8 Schizophrenia; LUSC trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg20587970 chr11:113659929 NA -1.23 -16.37 -0.67 1.18e-44 Hip circumference adjusted for BMI; LUSC cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg01849466 chr14:104193079 ZFYVE21 -0.55 -8.76 -0.43 9.73e-17 Schizophrenia; LUSC cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.88 -11.27 -0.52 3.51e-25 Chronic sinus infection; LUSC cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg01028140 chr2:1542097 TPO -0.6 -8.02 -0.4 1.86e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9372253 0.818 rs2207360 chr6:110706337 G/C cg01119278 chr6:110721349 DDO -0.47 -8.34 -0.42 1.93e-15 Platelet distribution width; LUSC cis rs722599 0.683 rs7145246 chr14:75242394 A/T cg08847533 chr14:75593920 NEK9 -0.46 -6.39 -0.33 5.48e-10 IgG glycosylation; LUSC cis rs3820068 0.608 rs12740492 chr1:16048951 A/T cg13390004 chr1:15929781 NA 0.4 6.5 0.33 2.99e-10 Systolic blood pressure; LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.78 0.3 1.72e-8 Menopause (age at onset); LUSC cis rs11098499 0.955 rs13129661 chr4:120152909 C/G cg09307838 chr4:120376055 NA 0.7 10.03 0.48 7.31e-21 Corneal astigmatism; LUSC cis rs4660306 1.000 rs2356561 chr1:45980862 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.68 -0.34 9.83e-11 Homocysteine levels; LUSC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg15595755 chr5:1867978 NA 0.45 8.15 0.41 7.3e-15 Cardiovascular disease risk factors; LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg14789911 chr21:47582049 C21orf56 0.39 6.22 0.32 1.48e-9 Testicular germ cell tumor; LUSC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg11764359 chr7:65958608 NA -0.69 -11.1 -0.52 1.42e-24 Aortic root size; LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.57 -8.91 -0.44 3.38e-17 Alzheimer's disease (late onset); LUSC trans rs11098499 0.865 rs28753180 chr4:120405367 A/T cg25214090 chr10:38739885 LOC399744 0.54 8.05 0.4 1.44e-14 Corneal astigmatism; LUSC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg11941060 chr3:133502564 NA -0.54 -8.41 -0.42 1.18e-15 Iron status biomarkers; LUSC trans rs61931739 0.817 rs866515 chr12:34215479 A/G cg26384229 chr12:38710491 ALG10B 0.54 8.61 0.43 2.89e-16 Morning vs. evening chronotype; LUSC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg18350739 chr11:68623251 NA -0.37 -6.36 -0.33 6.73e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs16854884 0.632 rs1466941 chr3:143670131 A/G cg06585982 chr3:143692056 C3orf58 0.52 8.13 0.41 8.4e-15 Economic and political preferences (feminism/equality); LUSC cis rs28374715 0.532 rs7164211 chr15:41705041 A/T cg18705301 chr15:41695430 NDUFAF1 -1.01 -22.2 -0.77 1.04e-67 Ulcerative colitis; LUSC cis rs73198271 0.562 rs76960788 chr8:8674049 C/T cg01851573 chr8:8652454 MFHAS1 0.67 8.61 0.43 2.93e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08811349 chr8:124286482 ZHX1 0.46 6.43 0.33 4.4e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21582582 chr3:182698605 DCUN1D1 -0.45 -8.21 -0.41 4.86e-15 Intelligence (multi-trait analysis); LUSC cis rs17155006 0.563 rs451416 chr7:107738531 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.3 -0.33 9.63e-10 Pneumococcal bacteremia; LUSC cis rs5758659 0.714 rs2413668 chr22:42505841 G/A cg04733989 chr22:42467013 NAGA -0.4 -6.58 -0.34 1.77e-10 Cognitive function; LUSC cis rs4909189 1.000 rs62493650 chr7:158135570 G/T cg23298862 chr7:158159286 PTPRN2 0.32 5.68 0.3 2.87e-8 Response to amphetamines; LUSC cis rs5769765 0.671 rs138817 chr22:50163058 G/A cg02269571 chr22:50332266 NA -0.48 -7.27 -0.37 2.63e-12 Schizophrenia; LUSC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg08219700 chr8:58056026 NA 0.7 7.95 0.4 2.95e-14 Developmental language disorder (linguistic errors); LUSC cis rs9322817 0.691 rs2499667 chr6:105319125 G/A cg02098413 chr6:105308735 HACE1 0.27 5.8 0.3 1.52e-8 Thyroid stimulating hormone; LUSC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg03517284 chr6:25882590 NA -0.44 -7.49 -0.38 6.29e-13 Intelligence (multi-trait analysis); LUSC cis rs4443100 0.670 rs13054331 chr22:23407063 G/A cg21100191 chr22:23484243 RTDR1 0.56 7.0 0.36 1.37e-11 Serum parathyroid hormone levels; LUSC cis rs3741151 0.686 rs11235809 chr11:73290163 A/G cg17517138 chr11:73019481 ARHGEF17 0.76 7.07 0.36 8.94e-12 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.8 -0.35 4.88e-11 Menopause (age at onset); LUSC cis rs13256369 0.865 rs13277708 chr8:8573936 T/C cg06671706 chr8:8559999 CLDN23 0.46 6.29 0.33 1.02e-9 Obesity-related traits; LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.64 0.6 5.64e-34 Platelet count; LUSC cis rs868036 0.609 rs2278076 chr15:68099600 C/T cg24579218 chr15:68104479 NA -0.4 -6.69 -0.34 9.64e-11 Restless legs syndrome; LUSC cis rs295140 1.000 rs3739121 chr2:201171014 G/C cg04283868 chr2:201171347 SPATS2L 0.44 6.63 0.34 1.36e-10 QT interval; LUSC cis rs9611565 0.649 rs2064189 chr22:42127999 A/G cg17376030 chr22:41985996 PMM1 -0.42 -5.68 -0.3 2.93e-8 Vitiligo; LUSC cis rs240764 0.621 rs6570930 chr6:101181258 C/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.54e-10 Neuroticism; LUSC cis rs7647973 0.771 rs9865051 chr3:49166069 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.64 8.62 0.43 2.79e-16 Menarche (age at onset); LUSC cis rs7072216 0.763 rs12763326 chr10:100167396 A/G cg26618903 chr10:100175079 PYROXD2 0.44 8.23 0.41 4.26e-15 Metabolite levels; LUSC cis rs9329221 0.621 rs12156350 chr8:10268516 T/G cg21775007 chr8:11205619 TDH -0.44 -6.02 -0.31 4.52e-9 Neuroticism; LUSC cis rs62432291 0.681 rs386818 chr6:159660255 T/C cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC cis rs9868809 0.881 rs57334642 chr3:48666795 C/T cg00383909 chr3:49044727 WDR6 1.0 8.42 0.42 1.14e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg14784868 chr12:69753453 YEATS4 0.61 9.21 0.45 3.79e-18 Blood protein levels; LUSC cis rs5758659 1.000 rs134873 chr22:42657566 T/G cg05082376 chr22:42548792 NA -0.4 -6.65 -0.34 1.22e-10 Cognitive function; LUSC cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC trans rs3942852 0.568 rs4412719 chr11:48101660 T/A cg15704280 chr7:45808275 SEPT13 -0.62 -8.17 -0.41 6.64e-15 Acute lymphoblastic leukemia (childhood); LUSC trans rs1015291 0.708 rs1586839 chr12:19998176 C/A cg01501474 chr7:55323552 NA -0.45 -5.97 -0.31 6.09e-9 Diastolic blood pressure; LUSC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg15335139 chr3:50242325 SLC38A3 -0.26 -5.71 -0.3 2.56e-8 Body mass index; LUSC cis rs3857536 0.813 rs2188589 chr6:66939570 C/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC trans rs7819412 0.521 rs10100660 chr8:11038885 T/A cg08975724 chr8:8085496 FLJ10661 -0.45 -6.17 -0.32 2.03e-9 Triglycerides; LUSC cis rs9341808 0.754 rs9294173 chr6:80991630 T/A cg08355045 chr6:80787529 NA 0.55 9.81 0.47 4.08e-20 Sitting height ratio; LUSC cis rs1538970 0.924 rs4660855 chr1:45899795 A/G cg05343316 chr1:45956843 TESK2 0.65 8.91 0.44 3.31e-17 Platelet count; LUSC cis rs500891 0.574 rs3798890 chr6:84119361 G/A cg08257003 chr6:84140564 ME1 0.34 7.6 0.38 3.06e-13 Platelet-derived growth factor BB levels; LUSC cis rs34779708 0.931 rs2244100 chr10:35323636 G/A cg04310649 chr10:35416472 CREM 0.4 6.26 0.32 1.18e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg08999081 chr20:33150536 PIGU 0.38 6.9 0.35 2.68e-11 Height; LUSC cis rs66887589 0.777 rs2017058 chr4:120257739 T/C cg24375607 chr4:120327624 NA 0.52 8.3 0.41 2.62e-15 Diastolic blood pressure; LUSC cis rs1568889 0.592 rs11828877 chr11:28384030 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.55 6.68 0.34 1.02e-10 Bipolar disorder; LUSC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg06112835 chr11:68658793 MRPL21 0.52 7.92 0.4 3.5e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg03790207 chr6:42947109 PEX6 -0.45 -6.93 -0.35 2.14e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7267979 1.000 rs6037086 chr20:25306338 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.52 -0.34 2.67e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9309473 0.950 rs6735946 chr2:73790058 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.45 -0.33 4.02e-10 Metabolite levels; LUSC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg06112835 chr11:68658793 MRPL21 0.51 7.58 0.38 3.39e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg22823121 chr1:150693482 HORMAD1 -0.56 -8.09 -0.4 1.08e-14 Melanoma; LUSC cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg12219531 chr12:120966889 COQ5 0.61 8.09 0.4 1.1e-14 High light scatter reticulocyte count; LUSC cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC cis rs12410462 0.681 rs115959512 chr1:227599578 T/C cg04117972 chr1:227635322 NA 0.75 7.37 0.37 1.33e-12 Major depressive disorder; LUSC cis rs7824557 0.767 rs3808509 chr8:11163256 G/T cg21775007 chr8:11205619 TDH 0.7 11.29 0.53 2.85e-25 Retinal vascular caliber; LUSC cis rs6840360 0.533 rs11099829 chr4:152727299 A/G cg22705602 chr4:152727874 NA 0.34 7.07 0.36 9.2e-12 Intelligence (multi-trait analysis); LUSC cis rs1256061 0.603 rs1256037 chr14:64743301 G/A cg23250157 chr14:64679961 SYNE2 0.32 5.71 0.3 2.56e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1865721 0.804 rs3745084 chr18:73142510 T/G cg26385618 chr18:73139727 C18orf62 -0.54 -9.92 -0.48 1.66e-20 Intelligence; LUSC cis rs7177699 0.557 rs9920493 chr15:79113846 A/C cg00540400 chr15:79124168 NA 0.46 8.1 0.41 1.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7937682 0.593 rs1113851 chr11:111354161 G/A cg09085632 chr11:111637200 PPP2R1B 0.44 5.87 0.31 1.04e-8 Primary sclerosing cholangitis; LUSC cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg19628046 chr18:33552617 C18orf21 0.48 5.76 0.3 1.92e-8 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg18876405 chr7:65276391 NA -0.57 -9.38 -0.46 1.06e-18 Aortic root size; LUSC cis rs6882046 0.513 rs454214 chr5:88003403 A/G cg22951263 chr5:87985283 NA 0.43 7.06 0.36 9.61e-12 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg26384229 chr12:38710491 ALG10B 0.87 14.76 0.63 2.57e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg11764359 chr7:65958608 NA -0.63 -9.44 -0.46 6.48e-19 Aortic root size; LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg00166722 chr3:10149974 C3orf24 0.58 7.81 0.39 7.42e-14 Alzheimer's disease; LUSC cis rs9467773 1.000 rs9467773 chr6:26498426 A/G cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.09e-18 Intelligence (multi-trait analysis); LUSC cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs2404602 0.622 rs11632365 chr15:77139080 G/A cg23625390 chr15:77176239 SCAPER -0.61 -8.65 -0.43 2.22e-16 Blood metabolite levels; LUSC cis rs11971779 0.680 rs3924296 chr7:139041927 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC trans rs2898290 0.622 rs978802 chr8:11343278 A/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.34 -0.33 7.51e-10 Systolic blood pressure; LUSC cis rs881375 0.967 rs758959 chr9:123676699 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.87 0.35 3.06e-11 Rheumatoid arthritis; LUSC cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg22782873 chr19:19639568 YJEFN3 -0.5 -6.21 -0.32 1.58e-9 Bipolar disorder; LUSC cis rs929354 0.772 rs2301916 chr7:156974127 G/T cg17757837 chr7:157058334 UBE3C 0.84 13.53 0.59 1.49e-33 Body mass index; LUSC cis rs1519814 1.000 rs12678023 chr8:121123494 G/A cg22335954 chr8:121166405 COL14A1 -0.41 -5.65 -0.3 3.44e-8 Breast cancer; LUSC cis rs208520 1.000 rs208535 chr6:66962286 G/A cg07460842 chr6:66804631 NA -0.96 -12.45 -0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg18758796 chr5:131593413 PDLIM4 0.44 7.07 0.36 9.24e-12 Breast cancer; LUSC cis rs10028773 0.600 rs4001390 chr4:120265783 G/C cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.4e-19 Educational attainment; LUSC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg14784868 chr12:69753453 YEATS4 0.81 13.73 0.6 2.58e-34 Blood protein levels; LUSC cis rs1018697 1.000 rs11191397 chr10:104558274 C/A cg04362960 chr10:104952993 NT5C2 0.46 6.41 0.33 5.1e-10 Colorectal adenoma (advanced); LUSC cis rs1801251 1.000 rs3817311 chr2:233612557 C/T cg08000102 chr2:233561755 GIGYF2 0.68 11.26 0.52 3.82e-25 Coronary artery disease; LUSC cis rs478304 0.654 rs10896034 chr11:65460783 T/A cg27068330 chr11:65405492 SIPA1 -0.74 -10.28 -0.49 9.83e-22 Acne (severe); LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg00684032 chr4:1343700 KIAA1530 0.38 6.6 0.34 1.62e-10 Obesity-related traits; LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg11645453 chr3:52864694 ITIH4 0.35 8.09 0.4 1.09e-14 Bipolar disorder; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.96 0.77 8.44e-67 Prudent dietary pattern; LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.94 0.66 6e-43 Platelet count; LUSC cis rs977987 0.835 rs1010630 chr16:75328591 G/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.68 -0.34 9.98e-11 Dupuytren's disease; LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.17 0.37 4.8e-12 Platelet count; LUSC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 11.13 0.52 1.12e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs929354 0.772 rs2366214 chr7:156992461 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg14835575 chr10:16859367 RSU1 0.72 9.28 0.45 2.12e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs6542838 0.588 rs4851174 chr2:99530113 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.46 -6.28 -0.33 1.04e-9 Fear of minor pain; LUSC trans rs17266958 1.000 rs17083747 chr9:83292983 A/C cg01905489 chr1:26616534 UBXN11 -0.59 -6.46 -0.33 3.62e-10 Preschool internalizing problems; LUSC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg25174290 chr11:3078921 CARS 0.57 8.58 0.42 3.72e-16 Type 2 diabetes; LUSC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.98 -0.4 2.39e-14 Mean platelet volume; LUSC cis rs1957429 0.614 rs17883073 chr14:65404059 G/A cg23373153 chr14:65346875 NA -0.98 -7.74 -0.39 1.16e-13 Pediatric areal bone mineral density (radius); LUSC trans rs225245 0.791 rs8067294 chr17:34027964 T/C cg19694781 chr19:47549865 TMEM160 -0.39 -6.2 -0.32 1.67e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21659725 chr3:3221576 CRBN -0.58 -8.2 -0.41 5.33e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs68170813 0.559 rs6971675 chr7:106833797 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.61 -0.47 1.89e-19 Coronary artery disease; LUSC cis rs4319547 0.698 rs10773178 chr12:122944752 T/C cg23029597 chr12:123009494 RSRC2 -0.71 -9.45 -0.46 6.22e-19 Body mass index; LUSC cis rs10781543 0.839 rs4379550 chr9:139376426 C/T cg14019695 chr9:139328340 INPP5E -0.5 -9.67 -0.47 1.18e-19 Monocyte percentage of white cells; LUSC cis rs7937682 0.924 rs10891284 chr11:111527737 T/C cg09085632 chr11:111637200 PPP2R1B -1.1 -17.98 -0.7 4.8e-51 Primary sclerosing cholangitis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10797726 chr6:82957093 IBTK 0.4 6.14 0.32 2.32e-9 Triglycerides; LUSC cis rs28735056 0.609 rs4799099 chr18:77639585 A/G cg20368463 chr18:77673604 PQLC1 0.68 9.85 0.47 2.82e-20 Schizophrenia; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg17372223 chr3:52568218 NT5DC2 0.4 6.34 0.33 7.56e-10 Electroencephalogram traits; LUSC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs10761482 0.954 rs10994305 chr10:62085999 A/C cg18175470 chr10:62150864 ANK3 -0.49 -6.86 -0.35 3.27e-11 Schizophrenia; LUSC cis rs2404602 0.552 rs11634428 chr15:77084582 T/C cg23625390 chr15:77176239 SCAPER -0.62 -8.66 -0.43 2.04e-16 Blood metabolite levels; LUSC cis rs1577917 0.518 rs6454482 chr6:86418188 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.52 8.09 0.4 1.1e-14 Response to antipsychotic treatment; LUSC cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg11584989 chr19:19387371 SF4 -0.55 -6.31 -0.33 8.61e-10 Bipolar disorder; LUSC cis rs3764563 0.877 rs4646526 chr19:15729773 A/G cg20725493 chr19:15740067 CYP4F8 -0.6 -6.59 -0.34 1.67e-10 Inflammatory biomarkers; LUSC cis rs75804782 0.521 rs56340711 chr2:239440080 A/T cg18131467 chr2:239335373 ASB1 -0.67 -6.01 -0.31 4.73e-9 Morning vs. evening chronotype;Chronotype; LUSC trans rs6951245 1.000 rs111899361 chr7:1112348 C/T cg13565492 chr6:43139072 SRF -0.63 -6.63 -0.34 1.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs868036 0.645 rs4776987 chr15:68123915 A/T cg24579218 chr15:68104479 NA 0.39 6.37 0.33 6.42e-10 Restless legs syndrome; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg11965913 chr1:205819406 PM20D1 0.91 18.84 0.72 1.91e-54 Menarche (age at onset); LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg17173187 chr15:85201210 NMB 0.47 8.85 0.44 5.16e-17 Schizophrenia; LUSC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.07e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.75 -0.35 6.47e-11 Alzheimer's disease (late onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08120389 chr17:19881268 AKAP10 -0.46 -6.08 -0.32 3.3e-9 Bipolar disorder and schizophrenia; LUSC trans rs2270927 0.510 rs246814 chr5:75599208 C/T cg13563193 chr19:33072644 PDCD5 0.74 6.02 0.31 4.54e-9 Mean corpuscular volume; LUSC cis rs7561273 0.586 rs7589717 chr2:24357463 G/A cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC cis rs453301 0.653 rs2956244 chr8:8885166 A/G cg08975724 chr8:8085496 FLJ10661 0.45 6.58 0.34 1.87e-10 Joint mobility (Beighton score); LUSC trans rs61931739 0.817 rs11833948 chr12:34276942 G/T cg24313572 chr1:56050060 NA -0.29 -6.1 -0.32 2.93e-9 Morning vs. evening chronotype; LUSC cis rs4803468 1.000 rs6508977 chr19:41909346 A/G cg09537434 chr19:41945824 ATP5SL -0.89 -15.8 -0.65 2.19e-42 Height; LUSC cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg17173187 chr15:85201210 NMB -0.37 -6.29 -0.33 9.98e-10 Schizophrenia; LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg12516959 chr21:47718080 NA -0.36 -6.09 -0.32 3.11e-9 Testicular germ cell tumor; LUSC cis rs7188861 0.724 rs34437200 chr16:11391710 G/A cg00044050 chr16:11439710 C16orf75 0.57 6.35 0.33 7.17e-10 HDL cholesterol; LUSC cis rs478304 0.903 rs1151502 chr11:65503485 G/C cg08755490 chr11:65554678 OVOL1 0.4 5.84 0.3 1.24e-8 Acne (severe); LUSC cis rs951266 0.505 rs11639372 chr15:78966655 C/T cg00540400 chr15:79124168 NA -0.33 -5.74 -0.3 2.11e-8 Post bronchodilator FEV1/FVC ratio in COPD;Pre bronchodilator FEV1;Pre bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4820539 0.966 rs5751590 chr22:23486830 A/C cg21100191 chr22:23484243 RTDR1 0.93 16.05 0.66 2.35e-43 Bone mineral density; LUSC cis rs243505 0.559 rs2072408 chr7:148508197 A/G cg09806900 chr7:148480153 CUL1 0.66 9.88 0.48 2.29e-20 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg18850127 chr7:39170497 POU6F2 0.67 11.0 0.52 3.09e-24 IgG glycosylation; LUSC cis rs9325144 0.647 rs12831609 chr12:39051576 C/A cg26384229 chr12:38710491 ALG10B -0.62 -9.61 -0.47 1.84e-19 Morning vs. evening chronotype; LUSC cis rs4595586 0.525 rs7968566 chr12:39377200 C/T cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg00198436 chr1:120839380 FAM72B 0.41 6.17 0.32 1.96e-9 Schizophrenia; LUSC cis rs7215564 0.908 rs34384177 chr17:78667040 A/T cg09596252 chr17:78655493 RPTOR 0.52 5.67 0.3 3.1e-8 Myopia (pathological); LUSC cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg05347473 chr6:146136440 FBXO30 0.54 9.24 0.45 2.91e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg05861140 chr6:150128134 PCMT1 -0.44 -7.13 -0.36 6.2e-12 Lung cancer; LUSC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg14983838 chr19:29218262 NA 0.56 6.53 0.34 2.49e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs11148252 0.740 rs9596648 chr13:52934569 A/T cg18335740 chr13:41363409 SLC25A15 -0.57 -8.64 -0.43 2.34e-16 Lewy body disease; LUSC cis rs870825 0.616 rs9631782 chr4:185626379 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06295032 chr4:113206875 TIFA -0.44 -6.8 -0.35 4.72e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg09455208 chr3:40491958 NA 0.53 9.39 0.46 9.85e-19 Renal cell carcinoma; LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.8 0.39 7.87e-14 Gut microbiome composition (summer); LUSC cis rs10392 0.543 rs56660421 chr20:37559329 G/T cg27552599 chr20:37590471 DHX35 0.46 7.32 0.37 1.92e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg19592336 chr6:28129416 ZNF389 0.51 6.67 0.34 1.06e-10 Parkinson's disease; LUSC trans rs11148252 0.514 rs3783242 chr13:52717950 C/T cg18335740 chr13:41363409 SLC25A15 0.47 6.88 0.35 2.93e-11 Lewy body disease; LUSC cis rs7592578 0.771 rs62181034 chr2:191354963 C/A cg11845111 chr2:191398756 TMEM194B -0.85 -10.7 -0.51 3.51e-23 Diastolic blood pressure; LUSC cis rs4595586 0.505 rs12827136 chr12:39412790 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.38 0.33 5.9e-10 Morning vs. evening chronotype; LUSC cis rs3733585 0.638 rs13145554 chr4:9979589 C/T cg00071950 chr4:10020882 SLC2A9 0.51 8.48 0.42 7.55e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg15704280 chr7:45808275 SEPT13 -0.57 -7.11 -0.36 7.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs10992471 0.603 rs10761163 chr9:95313287 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.81 -0.35 4.48e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs11608355 0.545 rs1073780 chr12:109895143 T/C cg05360138 chr12:110035743 NA 0.88 10.35 0.49 5.75e-22 Neuroticism; LUSC cis rs500891 0.525 rs6454321 chr6:84050941 A/G cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.08e-14 Platelet-derived growth factor BB levels; LUSC cis rs4072705 0.585 rs7852843 chr9:127233823 C/T cg13476313 chr9:127244764 NR5A1 -0.34 -6.69 -0.34 9.33e-11 Menarche (age at onset); LUSC cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg08213375 chr14:104286397 PPP1R13B 0.52 10.31 0.49 8.03e-22 Schizophrenia; LUSC cis rs7202877 0.561 rs7202083 chr16:75383727 G/T cg04384234 chr16:75411784 CFDP1 -0.6 -7.13 -0.36 6.32e-12 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7980687 0.657 rs2851447 chr12:123665113 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.77 -0.35 5.91e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs7772486 0.846 rs2748496 chr6:146321829 T/A cg23711669 chr6:146136114 FBXO30 0.85 15.19 0.64 5.38e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs11971779 0.680 rs3924445 chr7:139044172 C/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs4474465 0.790 rs10793331 chr11:78270000 C/T cg27205649 chr11:78285834 NARS2 0.52 6.24 0.32 1.29e-9 Alzheimer's disease (survival time); LUSC cis rs9486715 0.758 rs2971610 chr6:97027380 C/T cg06623918 chr6:96969491 KIAA0776 -0.93 -17.69 -0.7 6.87e-50 Headache; LUSC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.98 0.31 5.64e-9 Lung cancer; LUSC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg05802129 chr4:122689817 NA -0.52 -8.64 -0.43 2.3e-16 Type 2 diabetes; LUSC cis rs10927875 0.526 rs2179615 chr1:16282426 G/A cg21385522 chr1:16154831 NA -0.89 -12.48 -0.56 1.36e-29 Dilated cardiomyopathy; LUSC cis rs2070488 0.804 rs13085153 chr3:38461279 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 12.64 0.57 3.34e-30 Electrocardiographic conduction measures; LUSC cis rs2797160 1.000 rs1739375 chr6:126012013 T/C cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.94e-16 Endometrial cancer; LUSC cis rs1215050 0.791 rs165252 chr4:98758728 A/C cg05340658 chr4:99064831 C4orf37 0.44 6.85 0.35 3.55e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504073 0.584 rs11784268 chr8:49956339 T/G cg00325661 chr8:49890786 NA 0.7 11.2 0.52 6.03e-25 Blood metabolite ratios; LUSC cis rs734999 0.588 rs6668149 chr1:2558308 A/C cg18932078 chr1:2524107 MMEL1 -0.31 -6.93 -0.35 2.21e-11 Ulcerative colitis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11930279 chr12:12022652 ETV6 -0.81 -6.57 -0.34 1.89e-10 Cognitive performance; LUSC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg11861562 chr11:117069780 TAGLN -0.44 -7.96 -0.4 2.64e-14 Blood protein levels; LUSC cis rs9517320 0.967 rs9517317 chr13:99125711 G/C cg20487152 chr13:99095054 FARP1 0.34 6.4 0.33 5.25e-10 Longevity; LUSC cis rs13315871 0.929 rs35376204 chr3:58325563 T/C cg20936604 chr3:58311152 NA -0.77 -7.27 -0.37 2.56e-12 Cholesterol, total; LUSC trans rs7647973 0.626 rs1078341 chr3:49685592 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -7.09 -0.36 8.11e-12 Menarche (age at onset); LUSC cis rs7527798 0.592 rs6671969 chr1:207839667 C/T cg09232269 chr1:207846808 CR1L -0.27 -5.79 -0.3 1.64e-8 Erythrocyte sedimentation rate; LUSC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg02569458 chr12:86230093 RASSF9 -0.47 -7.93 -0.4 3.34e-14 Major depressive disorder; LUSC cis rs6504663 0.586 rs60117965 chr17:48569755 G/A cg03168497 chr17:48586147 MYCBPAP 0.49 6.42 0.33 4.6e-10 Visceral fat; LUSC cis rs7246967 0.611 rs73022711 chr19:22875404 G/A cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs2046867 0.862 rs57396880 chr3:72844785 G/A cg25664220 chr3:72788482 NA -0.69 -11.29 -0.53 3.05e-25 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg03929089 chr4:120376271 NA -0.94 -16.25 -0.66 3.8e-44 Height; LUSC cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.84 -0.44 5.55e-17 Monocyte percentage of white cells; LUSC cis rs9467711 0.606 rs1978 chr6:26377573 A/T cg09904177 chr6:26538194 HMGN4 -0.72 -6.72 -0.35 7.96e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9905704 0.624 rs6503891 chr17:57065924 A/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.61 -0.38 2.84e-13 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs7481584 0.581 rs366422 chr11:3053873 C/T cg25174290 chr11:3078921 CARS -0.42 -6.21 -0.32 1.61e-9 Calcium levels; LUSC cis rs73206853 0.841 rs7971568 chr12:110780612 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.43 0.33 4.37e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg00071950 chr4:10020882 SLC2A9 0.59 9.74 0.47 6.88e-20 Bone mineral density; LUSC cis rs240768 0.826 rs117366009 chr6:100959054 G/A cg12253828 chr6:101329408 ASCC3 0.84 5.85 0.31 1.15e-8 Economic and political preferences (immigration/crime); LUSC cis rs3770081 1.000 rs76052260 chr2:86328727 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.92 -0.35 2.37e-11 Facial emotion recognition (sad faces); LUSC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg12463550 chr7:65579703 CRCP 0.55 8.1 0.41 1.05e-14 Aortic root size; LUSC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg03233332 chr7:66118400 NA -0.42 -6.08 -0.32 3.25e-9 Aortic root size; LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.37 0.37 1.35e-12 Bipolar disorder; LUSC cis rs79349575 0.783 rs9747646 chr17:47016882 C/T cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs6712932 0.925 rs10210149 chr2:105839324 C/T cg26874229 chr2:105853672 NA -0.32 -5.99 -0.31 5.32e-9 Type 2 diabetes; LUSC cis rs778371 0.834 rs778364 chr2:233777859 A/G cg08000102 chr2:233561755 GIGYF2 0.54 6.85 0.35 3.58e-11 Schizophrenia; LUSC cis rs68170813 0.652 rs17482543 chr7:107169174 C/G cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg03732007 chr1:2071316 PRKCZ 0.6 11.25 0.52 3.94e-25 Height; LUSC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg16346588 chr10:242978 ZMYND11 -0.39 -5.69 -0.3 2.79e-8 Psychosis in Alzheimer's disease; LUSC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg16928487 chr17:17741425 SREBF1 -0.45 -9.06 -0.44 1.11e-17 Total body bone mineral density; LUSC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg12257692 chr3:49977190 RBM6 -0.26 -7.41 -0.38 1.05e-12 Body mass index; LUSC trans rs61931739 0.517 rs10844727 chr12:34017435 C/T cg13010199 chr12:38710504 ALG10B 0.53 7.92 0.4 3.56e-14 Morning vs. evening chronotype; LUSC cis rs4363385 0.747 rs12048412 chr1:152977092 A/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.84 -0.39 6.02e-14 Inflammatory skin disease; LUSC cis rs921665 0.831 rs6751452 chr2:3183930 T/G cg16434511 chr2:3151078 NA -0.59 -6.35 -0.33 6.99e-10 World class endurance athleticism; LUSC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg13699009 chr12:122356056 WDR66 0.51 7.9 0.4 4.12e-14 Mean corpuscular volume; LUSC cis rs1559088 1.000 rs1559087 chr19:33551041 A/G cg27124370 chr19:33622961 WDR88 0.52 6.71 0.34 8.59e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7208859 0.623 rs8082537 chr17:29015932 T/C cg13385521 chr17:29058706 SUZ12P 0.59 6.03 0.31 4.41e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7584330 0.737 rs7568588 chr2:238364342 G/T cg14458575 chr2:238380390 NA 0.68 12.06 0.55 4.8e-28 Prostate cancer; LUSC cis rs2637266 0.967 rs2579748 chr10:78328313 T/C cg18941641 chr10:78392320 NA 0.38 6.9 0.35 2.66e-11 Pulmonary function; LUSC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg14019146 chr3:50243930 SLC38A3 -0.32 -7.09 -0.36 7.88e-12 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg10896456 chr17:42255109 ASB16;C17orf65 0.49 8.94 0.44 2.69e-17 Total body bone mineral density; LUSC cis rs7577696 0.752 rs12618002 chr2:32347715 A/T cg02381751 chr2:32503542 YIPF4 -0.43 -5.86 -0.31 1.13e-8 Inflammatory biomarkers; LUSC cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.64 -0.6 5.38e-34 Chronic sinus infection; LUSC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.62 -0.6 6.89e-34 Intelligence (multi-trait analysis); LUSC cis rs478304 0.651 rs11604451 chr11:65551710 C/T cg17480646 chr11:65405466 SIPA1 -0.45 -5.83 -0.3 1.3e-8 Acne (severe); LUSC cis rs6752107 0.512 rs1372097 chr2:234227047 T/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.46 6.77 0.35 5.77e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12908161 0.959 rs1051168 chr15:85200520 G/T cg11189052 chr15:85197271 WDR73 0.48 5.96 0.31 6.31e-9 Schizophrenia; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs5769765 0.542 rs761878 chr22:50249677 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.62 6.57 0.34 1.96e-10 Schizophrenia; LUSC cis rs9303542 0.625 rs8064626 chr17:46567851 G/A cg09704116 chr17:46666958 LOC404266 -0.38 -6.42 -0.33 4.76e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs4704187 0.687 rs6864485 chr5:74497984 T/C cg03227963 chr5:74354835 NA 0.3 6.64 0.34 1.24e-10 Response to amphetamines; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 8.9 0.44 3.59e-17 Bipolar disorder; LUSC trans rs72834455 0.925 rs72834469 chr2:119518903 T/A cg02397686 chr17:73851076 WBP2 -0.65 -6.09 -0.32 3.19e-9 Tonsillectomy; LUSC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.81 12.23 0.56 1.16e-28 Cognitive test performance; LUSC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19346786 chr7:2764209 NA -0.51 -8.6 -0.43 3.22e-16 Height; LUSC cis rs1003719 0.713 rs2835594 chr21:38466064 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs7212938 0.509 rs3893044 chr17:38103016 C/T cg24910161 chr17:38119198 GSDMA 0.28 6.2 0.32 1.65e-9 Asthma and hay fever; LUSC cis rs2109514 0.967 rs10271007 chr7:116145849 A/G cg12739419 chr7:116140593 CAV2 -0.28 -6.3 -0.33 9.42e-10 Prevalent atrial fibrillation; LUSC cis rs679087 0.932 rs10843506 chr12:29930883 G/A cg14258853 chr12:29935411 TMTC1 0.85 14.64 0.63 7.49e-38 Schizophrenia; LUSC cis rs317689 0.690 rs570256 chr12:69662929 A/T cg20891283 chr12:69753455 YEATS4 0.43 5.77 0.3 1.77e-8 Response to diuretic therapy; LUSC cis rs8141529 0.732 rs5752798 chr22:29181868 A/G cg02153584 chr22:29168773 CCDC117 0.66 10.72 0.51 3.16e-23 Lymphocyte counts; LUSC cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg01884057 chr2:25150051 NA 0.47 11.19 0.52 6.54e-25 Body mass index; LUSC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.08 -0.32 3.31e-9 Developmental language disorder (linguistic errors); LUSC cis rs2289583 0.503 rs113742359 chr15:75261643 A/G cg10253484 chr15:75165896 SCAMP2 0.45 6.22 0.32 1.45e-9 Systemic lupus erythematosus; LUSC cis rs3924048 0.559 rs4075303 chr1:12626593 C/G cg23650765 chr1:12612165 NA 0.29 5.73 0.3 2.27e-8 Optic cup area; LUSC cis rs655601 1.000 rs655601 chr5:180226673 G/T cg13724780 chr5:180237085 MGAT1 -0.58 -5.83 -0.3 1.31e-8 Quantitative traits; LUSC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.5 7.99 0.4 2.2e-14 Menarche (age at onset); LUSC cis rs12950390 0.853 rs10445375 chr17:45864314 C/T cg03474202 chr17:45855739 NA 0.3 6.9 0.35 2.6e-11 IgG glycosylation; LUSC cis rs6582630 0.638 rs11182428 chr12:38526387 T/C cg26384229 chr12:38710491 ALG10B -0.57 -8.65 -0.43 2.17e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs17540621 1.000 rs115360269 chr2:47232527 C/T cg23978866 chr2:47230407 TTC7A -0.97 -6.63 -0.34 1.38e-10 Response to statin therapy; LUSC cis rs7833986 0.501 rs2667983 chr8:56894087 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.69 11.16 0.52 8.31e-25 Height; LUSC cis rs1577917 1.000 rs1857965 chr6:86630776 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC cis rs1595825 0.786 rs75415672 chr2:198535679 G/A cg19156104 chr2:198669113 PLCL1 -0.46 -5.73 -0.3 2.23e-8 Ulcerative colitis; LUSC trans rs561341 1.000 rs8070262 chr17:30262467 A/G cg27661571 chr11:113659931 NA -0.56 -6.61 -0.34 1.52e-10 Hip circumference adjusted for BMI; LUSC cis rs6430585 0.583 rs61253125 chr2:136618178 T/C cg07169764 chr2:136633963 MCM6 1.23 19.55 0.73 2.84e-57 Corneal structure; LUSC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg07212818 chr11:638076 DRD4 -0.42 -7.03 -0.36 1.16e-11 Systemic lupus erythematosus; LUSC cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs367615 0.552 rs2963024 chr5:108730773 C/T cg17395555 chr5:108820864 NA -0.43 -7.77 -0.39 9.76e-14 Colorectal cancer (SNP x SNP interaction); LUSC cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg05294307 chr14:35346193 BAZ1A -0.58 -6.65 -0.34 1.23e-10 Psoriasis; LUSC cis rs10791097 0.748 rs4937580 chr11:130734270 T/C cg12179176 chr11:130786555 SNX19 0.83 14.24 0.61 2.86e-36 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs3755132 0.929 rs6708314 chr2:15745211 T/C cg12888861 chr2:15731646 DDX1 0.5 7.27 0.37 2.55e-12 Wilms tumor; LUSC cis rs3008870 0.959 rs56707923 chr1:67388016 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.08 0.64 1.48e-39 Lymphocyte percentage of white cells; LUSC cis rs826838 0.967 rs7963716 chr12:38876090 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.69 0.65 5.96e-42 Heart rate; LUSC cis rs4343996 0.692 rs34148253 chr7:3454978 A/G cg21248987 chr7:3385318 SDK1 0.36 5.89 0.31 9.35e-9 Motion sickness; LUSC cis rs8017423 0.967 rs61996919 chr14:90701803 A/C cg04374321 chr14:90722782 PSMC1 0.73 11.62 0.54 1.91e-26 Mortality in heart failure; LUSC cis rs9815354 1.000 rs1716644 chr3:41968028 A/G cg03022575 chr3:42003672 ULK4 -0.58 -6.4 -0.33 5.41e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs8025790 0.508 rs12441823 chr15:67912977 C/T cg05925327 chr15:68127851 NA -0.42 -6.3 -0.33 9.14e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC trans rs72674100 0.881 rs72874647 chr4:97964813 A/G cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg10053473 chr17:62856997 LRRC37A3 -0.68 -10.88 -0.51 8.47e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs977987 0.898 rs12918797 chr16:75493810 T/C cg04384234 chr16:75411784 CFDP1 -0.48 -7.87 -0.4 5.05e-14 Dupuytren's disease; LUSC cis rs8017423 0.967 rs7151776 chr14:90724803 A/G cg04374321 chr14:90722782 PSMC1 0.71 11.54 0.53 3.65e-26 Mortality in heart failure; LUSC cis rs12681288 0.823 rs4735974 chr8:1000218 T/G cg04851639 chr8:1020857 NA -0.37 -7.91 -0.4 3.82e-14 Schizophrenia; LUSC cis rs11690935 0.959 rs6722757 chr2:172591963 A/G cg13550731 chr2:172543902 DYNC1I2 -0.87 -14.3 -0.62 1.62e-36 Schizophrenia; LUSC cis rs5769765 0.908 rs7410601 chr22:50317187 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.79 -10.11 -0.48 3.97e-21 Schizophrenia; LUSC cis rs2688608 0.967 rs1815076 chr10:75659886 C/T cg23231163 chr10:75533350 FUT11 -0.37 -5.96 -0.31 6.57e-9 Inflammatory bowel disease; LUSC cis rs9283706 0.594 rs7734953 chr5:66349943 G/T cg11590213 chr5:66331682 MAST4 0.49 7.22 0.37 3.44e-12 Coronary artery disease; LUSC cis rs3008870 0.755 rs2208577 chr1:67513574 A/C cg02640540 chr1:67518911 SLC35D1 0.6 8.62 0.43 2.66e-16 Lymphocyte percentage of white cells; LUSC cis rs738322 0.555 rs6001029 chr22:38555193 C/A cg25457927 chr22:38595422 NA -0.41 -8.08 -0.4 1.16e-14 Cutaneous nevi; LUSC trans rs4332037 0.624 rs56256289 chr7:1892529 C/T cg11693508 chr17:37793320 STARD3 0.51 6.46 0.33 3.81e-10 Bipolar disorder; LUSC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18404041 chr3:52824283 ITIH1 -0.51 -9.86 -0.47 2.61e-20 Bipolar disorder; LUSC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC cis rs9341808 0.935 rs2322633 chr6:80845989 C/T cg08355045 chr6:80787529 NA -0.49 -8.66 -0.43 1.99e-16 Sitting height ratio; LUSC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.17 -0.32 2.03e-9 Total body bone mineral density; LUSC trans rs801193 0.613 rs2016325 chr7:66323500 T/C cg18876405 chr7:65276391 NA -0.55 -9.09 -0.45 9.05e-18 Aortic root size; LUSC cis rs9796 0.866 rs1678750 chr15:41410705 G/A cg18705301 chr15:41695430 NDUFAF1 -0.46 -8.04 -0.4 1.55e-14 Menopause (age at onset); LUSC cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.93 0.51 5.81e-24 Bladder cancer; LUSC cis rs2073300 0.609 rs34648279 chr20:23402935 T/G cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs208520 1.000 rs12190187 chr6:66973207 T/G cg07460842 chr6:66804631 NA 0.95 12.31 0.56 5.59e-29 Exhaled nitric oxide output; LUSC cis rs1865760 0.622 rs10946807 chr6:26079638 T/C cg17042849 chr6:26104293 HIST1H4C -0.42 -5.88 -0.31 9.82e-9 Height; LUSC cis rs16912285 0.748 rs12786638 chr11:24346006 A/G ch.11.24196551F chr11:24239977 NA 0.85 8.32 0.41 2.31e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg15691649 chr6:25882328 NA -0.6 -8.9 -0.44 3.74e-17 Urate levels; LUSC cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg17848003 chr1:3704513 LRRC47 0.31 6.01 0.31 4.86e-9 Red cell distribution width; LUSC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg23630131 chr7:65973040 NA -0.21 -5.9 -0.31 8.71e-9 Aortic root size; LUSC cis rs12410462 0.581 rs77837509 chr1:227559873 C/T cg04117972 chr1:227635322 NA 0.61 6.56 0.34 2e-10 Major depressive disorder; LUSC cis rs354225 0.544 rs3796017 chr2:54807452 T/A cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg03354898 chr7:1950403 MAD1L1 -0.34 -6.47 -0.33 3.56e-10 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.25 0.59 1.67e-32 Chronic sinus infection; LUSC trans rs76248362 1.000 rs9510907 chr13:24435564 A/C cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs6723226 0.721 rs10172510 chr2:32620888 A/G cg02381751 chr2:32503542 YIPF4 0.48 6.98 0.36 1.57e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg11764359 chr7:65958608 NA -0.79 -13.29 -0.59 1.17e-32 Aortic root size; LUSC cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg08917208 chr2:24149416 ATAD2B -0.54 -6.1 -0.32 2.99e-9 Lymphocyte counts; LUSC trans rs853679 0.546 rs17695758 chr6:27837183 T/C cg06606381 chr12:133084897 FBRSL1 -1.02 -9.08 -0.44 9.93e-18 Depression; LUSC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg25072359 chr17:41440525 NA 0.64 9.21 0.45 3.69e-18 Menopause (age at onset); LUSC cis rs79387448 0.745 rs17027421 chr2:103159882 A/G cg09003973 chr2:102972529 NA 0.88 8.56 0.42 4.18e-16 Gut microbiota (bacterial taxa); LUSC cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg24558204 chr6:135376177 HBS1L 0.68 10.82 0.51 1.32e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6977660 0.943 rs10240816 chr7:19819620 A/C cg07541023 chr7:19748670 TWISTNB 0.51 5.81 0.3 1.49e-8 Thyroid stimulating hormone; LUSC cis rs2067615 0.524 rs10778500 chr12:107074410 T/A cg15890332 chr12:107067104 RFX4 0.36 6.33 0.33 7.72e-10 Heart rate; LUSC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.13e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7917772 0.582 rs10883744 chr10:104347247 A/G cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2274273 0.870 rs10142547 chr14:55763963 T/C cg04306507 chr14:55594613 LGALS3 0.56 13.23 0.59 2.05e-32 Protein biomarker; LUSC cis rs757278 0.526 rs10272233 chr7:117309974 G/A cg10524701 chr7:117356490 CTTNBP2 0.4 5.75 0.3 1.99e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs6494488 0.500 rs77463022 chr15:65064841 G/A cg08069370 chr15:64387884 SNX1 -0.65 -5.91 -0.31 8.23e-9 Coronary artery disease; LUSC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.17 0.32 1.97e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg20573242 chr4:122745356 CCNA2 0.59 8.68 0.43 1.8e-16 Type 2 diabetes; LUSC cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg13256891 chr4:100009986 ADH5 -0.48 -6.42 -0.33 4.69e-10 Alcohol dependence; LUSC trans rs11098499 0.955 rs6815725 chr4:120158410 C/A cg25214090 chr10:38739885 LOC399744 0.45 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs7923452 1.000 rs7923452 chr10:30751171 T/C cg25182066 chr10:30743637 MAP3K8 0.56 6.61 0.34 1.51e-10 Itch intensity from mosquito bite; LUSC cis rs13315871 0.929 rs9837903 chr3:58301906 A/T cg20936604 chr3:58311152 NA -0.71 -6.73 -0.35 7.52e-11 Cholesterol, total; LUSC cis rs295140 0.586 rs4673904 chr2:201163454 A/T cg04283868 chr2:201171347 SPATS2L 0.42 6.38 0.33 6.04e-10 QT interval; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg13293757 chr3:48487975 ATRIP 0.63 6.05 0.31 3.95e-9 Body mass index; LUSC cis rs6964587 1.000 rs11981461 chr7:91692662 A/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs13082711 0.522 rs6551192 chr3:27343376 C/T cg02860705 chr3:27208620 NA 0.45 8.33 0.41 2.07e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6964587 1.000 rs6969981 chr7:91689461 G/C cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC trans rs853679 0.542 rs2295594 chr6:28053097 G/A cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg11062466 chr8:58055876 NA 0.46 6.23 0.32 1.4e-9 Developmental language disorder (linguistic errors); LUSC cis rs981844 0.712 rs1037654 chr4:154750300 C/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC cis rs7843479 0.965 rs11135763 chr8:21813962 A/G cg17168535 chr8:21777572 XPO7 0.67 10.34 0.49 6.42e-22 Mean corpuscular volume; LUSC cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -9.19 -0.45 4.4e-18 Axial length; LUSC cis rs17030434 1.000 rs12645134 chr4:154713430 T/C cg14289246 chr4:154710475 SFRP2 -0.52 -6.91 -0.35 2.48e-11 Electrocardiographic conduction measures; LUSC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg20503657 chr10:835505 NA 0.73 9.19 0.45 4.2e-18 Eosinophil percentage of granulocytes; LUSC trans rs2262909 0.853 rs56207853 chr19:22292357 C/T cg17074339 chr11:11642133 GALNTL4 0.43 6.64 0.34 1.3e-10 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.546 rs9993299 chr4:98815976 G/A cg05340658 chr4:99064831 C4orf37 0.62 9.0 0.44 1.68e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs1865760 0.865 rs9467648 chr6:25957933 T/A cg16482183 chr6:26056742 HIST1H1C 0.46 6.82 0.35 4.18e-11 Height; LUSC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg27068330 chr11:65405492 SIPA1 -0.46 -5.88 -0.31 1.02e-8 Breast cancer; LUSC cis rs10504229 0.680 rs11777459 chr8:58044241 A/T cg08677398 chr8:58056175 NA 0.43 5.66 0.3 3.24e-8 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg09365446 chr1:150670422 GOLPH3L 0.47 6.88 0.35 3.03e-11 Melanoma; LUSC cis rs62064224 0.791 rs17806082 chr17:30705346 G/C cg09324608 chr17:30823087 MYO1D 0.35 5.85 0.3 1.2e-8 Schizophrenia; LUSC cis rs7582180 1.000 rs10865039 chr2:100907351 A/G cg08017756 chr2:100939284 LONRF2 -0.36 -6.0 -0.31 5.2e-9 Intelligence (multi-trait analysis); LUSC cis rs7577696 0.512 rs212691 chr2:32438075 G/A cg02381751 chr2:32503542 YIPF4 0.53 6.84 0.35 3.76e-11 Inflammatory biomarkers; LUSC cis rs12760731 0.565 rs34676994 chr1:178054513 A/T cg00404053 chr1:178313656 RASAL2 0.75 6.89 0.35 2.76e-11 Obesity-related traits; LUSC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg12963246 chr6:28129442 ZNF389 0.52 7.12 0.36 6.72e-12 Depression; LUSC cis rs2932538 0.744 rs6537742 chr1:113085197 G/T cg22162597 chr1:113214053 CAPZA1 0.63 8.3 0.41 2.61e-15 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg08219700 chr8:58056026 NA 0.66 7.82 0.39 7.08e-14 Developmental language disorder (linguistic errors); LUSC cis rs2798269 0.831 rs11148157 chr13:22137608 A/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.04 -0.31 4.15e-9 PR segment; LUSC trans rs66887589 0.967 rs59516282 chr4:120502016 G/A cg25214090 chr10:38739885 LOC399744 -0.37 -6.0 -0.31 5.03e-9 Diastolic blood pressure; LUSC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs9916302 0.706 rs7503377 chr17:37708841 A/G cg07936489 chr17:37558343 FBXL20 -0.86 -11.04 -0.52 2.27e-24 Glomerular filtration rate (creatinine); LUSC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg06544989 chr22:39130855 UNC84B 0.38 6.76 0.35 6.02e-11 Menopause (age at onset); LUSC cis rs8114671 1.000 rs8114671 chr20:33789142 C/A cg24642439 chr20:33292090 TP53INP2 -0.41 -5.93 -0.31 7.41e-9 Height; LUSC trans rs61931739 0.517 rs56308002 chr12:34016021 C/G cg26384229 chr12:38710491 ALG10B 0.73 11.38 0.53 1.4e-25 Morning vs. evening chronotype; LUSC cis rs9987353 0.566 rs34491841 chr8:9065510 C/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.59 -0.34 1.73e-10 Recombination measurement; LUSC cis rs1949733 0.816 rs2631746 chr4:8490934 C/T cg13073564 chr4:8508604 NA 0.37 7.05 0.36 1.05e-11 Response to antineoplastic agents; LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg13047869 chr3:10149882 C3orf24 0.61 8.47 0.42 7.71e-16 Alzheimer's disease; LUSC cis rs9311676 0.656 rs11130634 chr3:58379123 A/C cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC cis rs4988958 0.584 rs7589142 chr2:103024660 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma (childhood onset); LUSC cis rs1801251 0.893 rs6733151 chr2:233592341 A/C cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.33 2.96e-10 Coronary artery disease; LUSC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg21361702 chr7:150065534 REPIN1 0.58 8.35 0.42 1.86e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg06792262 chr3:44622596 ZNF167 0.33 5.68 0.3 2.98e-8 Depressive symptoms; LUSC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg25019033 chr10:957182 NA -0.53 -6.75 -0.35 6.68e-11 Eosinophil percentage of granulocytes; LUSC cis rs7072216 0.763 rs12259939 chr10:100169021 T/C cg26618903 chr10:100175079 PYROXD2 -0.47 -8.56 -0.42 4.33e-16 Metabolite levels; LUSC cis rs453301 0.686 rs6987107 chr8:8893581 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.71 -0.39 1.43e-13 Joint mobility (Beighton score); LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.24 0.52 4.35e-25 Menopause (age at onset); LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg03354898 chr7:1950403 MAD1L1 -0.43 -8.7 -0.43 1.52e-16 Bipolar disorder and schizophrenia; LUSC cis rs17253792 0.822 rs78824140 chr14:56042715 G/T cg01858014 chr14:56050164 KTN1 -0.87 -6.92 -0.35 2.29e-11 Putamen volume; LUSC cis rs9039 1.000 rs9932208 chr16:9218267 T/C cg08831531 chr16:9218945 NA -0.66 -10.44 -0.5 2.78e-22 Menopause (age at onset); LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg26354017 chr1:205819088 PM20D1 0.43 6.15 0.32 2.19e-9 Menarche (age at onset); LUSC cis rs1728785 0.901 rs1170444 chr16:68573287 T/C cg02972257 chr16:68554789 NA -0.48 -6.07 -0.32 3.39e-9 Ulcerative colitis; LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18404041 chr3:52824283 ITIH1 -0.58 -11.52 -0.53 4.35e-26 Bipolar disorder; LUSC trans rs877282 0.945 rs11253396 chr10:789754 C/T cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs4363385 0.588 rs6660878 chr1:153027068 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -5.96 -0.31 6.27e-9 Inflammatory skin disease; LUSC cis rs611744 0.538 rs2298605 chr8:109272006 T/C cg21045802 chr8:109455806 TTC35 0.46 7.12 0.36 6.47e-12 Dupuytren's disease; LUSC trans rs11098499 0.863 rs1552092 chr4:120488496 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.22e-13 Corneal astigmatism; LUSC cis rs826838 0.935 rs1601579 chr12:39178606 G/C cg13010199 chr12:38710504 ALG10B 0.7 11.97 0.55 1.04e-27 Heart rate; LUSC cis rs7267979 1.000 rs2482911 chr20:25395528 T/C cg03522245 chr20:25566470 NINL -0.35 -5.72 -0.3 2.36e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs700651 0.789 rs1371663 chr2:198900305 C/T cg00792783 chr2:198669748 PLCL1 -0.43 -5.71 -0.3 2.5e-8 Intracranial aneurysm; LUSC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg05738196 chr6:26577821 NA 0.53 8.32 0.41 2.23e-15 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg13390004 chr1:15929781 NA 0.42 6.98 0.36 1.61e-11 Systolic blood pressure; LUSC cis rs1395 0.710 rs11682913 chr2:27473649 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.22 0.37 3.53e-12 Blood metabolite levels; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg22963979 chr7:1858916 MAD1L1 -0.7 -11.74 -0.54 7.13e-27 Bipolar disorder and schizophrenia; LUSC cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg16586182 chr3:47516702 SCAP -0.52 -7.99 -0.4 2.18e-14 Colorectal cancer; LUSC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6733011 0.518 rs12712033 chr2:99457973 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -5.69 -0.3 2.74e-8 Bipolar disorder; LUSC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg20243544 chr17:37824526 PNMT 0.48 6.1 0.32 3e-9 Glomerular filtration rate (creatinine); LUSC cis rs68170813 0.652 rs117775624 chr7:107124113 C/T cg02696742 chr7:106810147 HBP1 -0.64 -8.39 -0.42 1.39e-15 Coronary artery disease; LUSC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.98 0.48 1.09e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg08999081 chr20:33150536 PIGU 0.52 10.41 0.49 3.65e-22 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.78 0.3 1.74e-8 Menopause (age at onset); LUSC cis rs7789940 0.904 rs6953281 chr7:75946943 C/T cg10167463 chr7:75959203 YWHAG -0.63 -9.32 -0.45 1.61e-18 Multiple sclerosis; LUSC cis rs12540874 0.698 rs3807566 chr7:50564204 G/T cg18232548 chr7:50535776 DDC -0.58 -8.63 -0.43 2.48e-16 Systemic sclerosis; LUSC trans rs747782 0.527 rs76142260 chr11:48331068 T/C cg15704280 chr7:45808275 SEPT13 0.77 6.58 0.34 1.84e-10 Intraocular pressure; LUSC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg00933542 chr6:150070202 PCMT1 0.29 5.91 0.31 8.45e-9 Lung cancer; LUSC cis rs1055129 0.560 rs3682 chr17:73942150 A/G cg08125733 chr17:73851984 WBP2 0.47 6.48 0.33 3.23e-10 White matter hyperintensity burden; LUSC cis rs11031096 0.621 rs11031159 chr11:4179695 T/G cg18678763 chr11:4115507 RRM1 -0.41 -5.82 -0.3 1.38e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8060686 0.545 rs8056649 chr16:68260083 A/G cg05110241 chr16:68378359 PRMT7 0.54 6.38 0.33 5.78e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs3820928 0.874 rs1114562 chr2:227788592 T/C cg11843606 chr2:227700838 RHBDD1 -0.55 -8.01 -0.4 1.99e-14 Pulmonary function; LUSC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg13798780 chr7:105162888 PUS7 0.56 6.12 0.32 2.55e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg24060327 chr5:131705240 SLC22A5 -0.53 -8.78 -0.43 8.66e-17 Acylcarnitine levels; LUSC cis rs67696533 0.588 rs6141743 chr20:31107399 C/G cg13636640 chr20:31349939 DNMT3B 0.46 6.17 0.32 1.95e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs12980942 0.591 rs3760660 chr19:41769025 A/T cg25627403 chr19:41769009 HNRNPUL1 0.69 7.22 0.37 3.45e-12 Coronary artery disease; LUSC trans rs7647973 0.593 rs7620848 chr3:49828021 G/C cg21659725 chr3:3221576 CRBN 0.68 8.24 0.41 3.83e-15 Menarche (age at onset); LUSC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg19774624 chr17:42201019 HDAC5 -0.45 -6.47 -0.33 3.57e-10 Red cell distribution width;Reticulocyte count; LUSC cis rs78707713 0.512 rs12412776 chr10:71179502 G/A cg12610070 chr10:71211762 TSPAN15 -0.52 -9.74 -0.47 6.63e-20 Venous thromboembolism; LUSC trans rs2953145 0.568 rs2975752 chr2:241521327 A/G cg12966876 chr2:111873850 ACOXL 0.32 6.0 0.31 5.13e-9 Bipolar disorder; LUSC cis rs9300255 0.602 rs2851450 chr12:123703501 C/T cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs892961 0.899 rs72896162 chr17:75412521 A/G cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs8112211 0.911 rs60071299 chr19:38850246 G/A cg14299480 chr19:38876666 GGN -0.37 -6.29 -0.33 9.87e-10 Blood protein levels; LUSC trans rs61931739 0.500 rs11052994 chr12:34065843 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.48 0.53 5.99e-26 Morning vs. evening chronotype; LUSC cis rs9611565 0.572 rs139569 chr22:42211141 A/G cg03806693 chr22:41940476 POLR3H -0.83 -12.27 -0.56 8.06e-29 Vitiligo; LUSC cis rs9905704 0.846 rs11079356 chr17:56864242 C/A cg12560992 chr17:57184187 TRIM37 0.58 8.38 0.42 1.5e-15 Testicular germ cell tumor; LUSC trans rs1493916 0.870 rs7235698 chr18:31382486 A/G cg27147174 chr7:100797783 AP1S1 -0.66 -10.78 -0.51 1.89e-23 Life satisfaction; LUSC cis rs734999 0.566 rs10752747 chr1:2524915 G/T cg18854424 chr1:2615690 NA 0.49 9.67 0.47 1.15e-19 Ulcerative colitis; LUSC cis rs1007190 0.764 rs8070598 chr17:42876865 T/C cg15406952 chr17:42872593 NA -0.59 -6.18 -0.32 1.84e-9 DNA methylation (variation); LUSC cis rs2439831 0.618 rs8023508 chr15:44176103 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.64 -6.5 -0.34 2.86e-10 Lung cancer in ever smokers; LUSC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg02423579 chr7:2872169 GNA12 -0.41 -6.31 -0.33 8.91e-10 Height; LUSC cis rs4285028 0.603 rs79312528 chr3:121608997 T/C cg11130432 chr3:121712080 ILDR1 -0.65 -9.64 -0.47 1.41e-19 Multiple sclerosis; LUSC cis rs1882538 0.506 rs7805858 chr7:133126589 G/T cg10665199 chr7:133106180 EXOC4 0.54 7.43 0.38 9.17e-13 Intelligence (multi-trait analysis); LUSC cis rs3772130 0.923 rs13090798 chr3:121482768 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.13 0.48 3.38e-21 Cognitive performance; LUSC cis rs1957429 0.901 rs1957432 chr14:65352796 A/G cg23373153 chr14:65346875 NA 0.89 11.18 0.52 7.39e-25 Pediatric areal bone mineral density (radius); LUSC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg15839431 chr19:19639596 YJEFN3 -0.63 -7.11 -0.36 7.15e-12 Bipolar disorder; LUSC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg00310523 chr12:86230176 RASSF9 0.49 9.39 0.46 9.64e-19 Major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18732869 chr19:6739680 TRIP10 -0.51 -6.69 -0.34 9.55e-11 Bipolar disorder and schizophrenia; LUSC cis rs920590 0.758 rs7012358 chr8:19662498 C/T cg03894339 chr8:19674705 INTS10 0.48 6.48 0.33 3.2e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg17264618 chr3:40429014 ENTPD3 0.36 7.43 0.38 9.09e-13 Renal cell carcinoma; LUSC cis rs17014483 0.749 rs3017899 chr4:89643997 C/G cg01026744 chr4:89619053 NAP1L5;HERC3 0.66 5.75 0.3 1.98e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs11122272 0.735 rs2244986 chr1:231537452 C/T cg06096015 chr1:231504339 EGLN1 0.55 9.93 0.48 1.55e-20 Hemoglobin concentration; LUSC cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg06582575 chr6:163149167 PACRG;PARK2 -0.56 -8.41 -0.42 1.23e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9951602 0.512 rs6506868 chr18:76642559 C/G cg02800362 chr5:177631904 HNRNPAB 0.83 12.38 0.56 3.21e-29 Obesity-related traits; LUSC cis rs12912251 0.947 rs12899449 chr15:38995491 A/G cg01338139 chr15:38987640 C15orf53 -0.49 -6.9 -0.35 2.68e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs73129298 0.551 rs6012790 chr20:48601580 A/G cg25655593 chr20:48599521 SNAI1 0.59 6.36 0.33 6.69e-10 Inflammatory skin disease; LUSC cis rs9868809 0.772 rs9812200 chr3:48695667 A/G cg00383909 chr3:49044727 WDR6 -0.85 -7.74 -0.39 1.18e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19709743 chr11:118230230 UBE4A -0.47 -6.0 -0.31 5.26e-9 Bipolar disorder and schizophrenia; LUSC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg18306943 chr3:40428807 ENTPD3 0.4 5.96 0.31 6.5e-9 Renal cell carcinoma; LUSC cis rs2806561 0.828 rs604030 chr1:23518227 T/C cg12483005 chr1:23474871 LUZP1 0.42 6.63 0.34 1.37e-10 Height; LUSC cis rs1670533 1.000 rs2045066 chr4:1052401 C/T cg27284194 chr4:1044797 NA 0.53 8.14 0.41 7.97e-15 Recombination rate (females); LUSC cis rs9300255 0.602 rs1716172 chr12:123712712 G/T cg00376283 chr12:123451042 ABCB9 0.65 8.3 0.41 2.63e-15 Neutrophil percentage of white cells; LUSC trans rs7170930 0.618 rs55882547 chr15:66542766 T/C cg06396762 chr16:3202609 NA -0.72 -5.98 -0.31 5.75e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg12463550 chr7:65579703 CRCP 0.42 6.01 0.31 4.93e-9 Aortic root size; LUSC cis rs2839186 0.967 rs17176131 chr21:47705237 T/C cg11766577 chr21:47581405 C21orf56 -0.42 -6.14 -0.32 2.29e-9 Testicular germ cell tumor; LUSC cis rs859767 0.812 rs842358 chr2:135345109 C/T cg12500956 chr2:135428796 TMEM163 0.26 5.8 0.3 1.5e-8 Neuroticism; LUSC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg00343986 chr7:65444356 GUSB 0.4 5.91 0.31 8.22e-9 Aortic root size; LUSC cis rs9467773 0.649 rs2145318 chr6:26496603 T/A cg05738196 chr6:26577821 NA 0.67 11.16 0.52 8.39e-25 Intelligence (multi-trait analysis); LUSC cis rs12594515 0.967 rs71405295 chr15:45988921 T/C cg19682013 chr15:45996608 NA 0.39 6.0 0.31 5.09e-9 Waist circumference;Weight; LUSC cis rs968567 0.689 rs61897795 chr11:61618169 A/G cg00603274 chr11:61596626 FADS2 -0.54 -6.78 -0.35 5.48e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs9341808 0.667 rs6938280 chr6:80897782 G/A cg08355045 chr6:80787529 NA 0.47 8.13 0.41 8.26e-15 Sitting height ratio; LUSC cis rs7615952 0.515 rs4267608 chr3:125680500 C/T cg18479299 chr3:125709523 NA -0.48 -5.65 -0.3 3.42e-8 Blood pressure (smoking interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20894246 chr22:41682263 RANGAP1 0.47 6.53 0.34 2.47e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6433857 0.657 rs2368178 chr2:181501938 T/C cg23363182 chr2:181467187 NA -0.52 -8.38 -0.42 1.49e-15 Body mass index; LUSC cis rs3087591 0.919 rs9913470 chr17:29566575 A/G cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.88 -0.4 4.55e-14 Hip circumference; LUSC cis rs500891 0.645 rs7751382 chr6:84176515 A/G cg08257003 chr6:84140564 ME1 0.32 7.28 0.37 2.45e-12 Platelet-derived growth factor BB levels; LUSC cis rs4474465 1.000 rs10793316 chr11:78211928 C/A cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs3858526 0.834 rs7939099 chr11:5995792 G/A cg13902645 chr11:5959945 NA -0.57 -7.9 -0.4 4.07e-14 DNA methylation (variation); LUSC trans rs561341 0.629 rs7216107 chr17:30224419 G/A cg20587970 chr11:113659929 NA -0.62 -8.82 -0.43 6.25e-17 Hip circumference adjusted for BMI; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC trans rs11039571 0.588 rs10734564 chr11:48160429 A/G cg03929089 chr4:120376271 NA -0.6 -6.25 -0.32 1.22e-9 D-dimer levels; LUSC cis rs765787 0.530 rs55920042 chr15:45541577 G/A cg25801113 chr15:45476975 SHF 0.34 7.04 0.36 1.13e-11 Uric acid levels; LUSC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 9.46 0.46 5.67e-19 Menopause (age at onset); LUSC cis rs8060686 0.641 rs113790673 chr16:68244347 C/T cg27539214 chr16:67997921 SLC12A4 -0.56 -7.19 -0.37 4.3e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg08088566 chr11:430123 ANO9 0.67 7.64 0.39 2.34e-13 Body mass index; LUSC cis rs3760982 0.585 rs68073292 chr19:44291401 T/C cg11993925 chr19:44307056 LYPD5 0.35 7.63 0.39 2.55e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10120925 chr2:223520811 FARSB 0.78 6.1 0.32 2.91e-9 Cognitive performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11520162 chr1:2517947 C1orf93 -0.42 -6.33 -0.33 7.85e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs61931739 0.500 rs7313094 chr12:34457508 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.37e-18 Morning vs. evening chronotype; LUSC cis rs10465746 0.935 rs12406984 chr1:84416215 C/G cg10977910 chr1:84465055 TTLL7 0.43 6.3 0.33 9.25e-10 Obesity-related traits; LUSC trans rs979233 0.502 rs276260 chr5:42066357 G/A cg07010552 chr17:7358735 CHRNB1 -0.42 -6.02 -0.31 4.47e-9 Systemic lupus erythematosus; LUSC cis rs9549367 0.713 rs9549691 chr13:113861606 A/C cg00898013 chr13:113819073 PROZ -0.62 -8.97 -0.44 2.14e-17 Platelet distribution width; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19777004 chr4:49526489 NA -0.34 -6.02 -0.31 4.56e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg26597838 chr10:835615 NA 0.99 13.84 0.6 9.92e-35 Eosinophil percentage of granulocytes; LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg21724239 chr8:58056113 NA 0.69 8.88 0.44 4.09e-17 Developmental language disorder (linguistic errors); LUSC cis rs35883536 0.528 rs1414414 chr1:101028907 T/C cg09408571 chr1:101003634 GPR88 0.32 6.41 0.33 4.89e-10 Monocyte count; LUSC cis rs9304742 0.962 rs1808106 chr19:53452944 T/G cg09915433 chr19:53449742 NA -0.64 -10.3 -0.49 8.38e-22 Psoriasis; LUSC cis rs4740619 0.619 rs10810527 chr9:16043350 C/G cg14451791 chr9:16040625 NA 0.31 6.11 0.32 2.74e-9 Body mass index; LUSC cis rs9640161 0.830 rs35635199 chr7:150063342 C/T cg10018233 chr7:150070692 REPIN1 0.4 7.14 0.36 6e-12 Blood protein levels;Circulating chemerin levels; LUSC trans rs7618501 0.633 rs9861216 chr3:50059339 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -8.65 -0.43 2.17e-16 Intelligence (multi-trait analysis); LUSC cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg17507749 chr15:85114479 UBE2QP1 0.53 5.94 0.31 7.04e-9 Schizophrenia; LUSC trans rs7618501 0.633 rs9853222 chr3:50022926 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.56 9.02 0.44 1.46e-17 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18404041 chr3:52824283 ITIH1 -0.62 -12.01 -0.55 7.56e-28 Bipolar disorder; LUSC cis rs1775715 0.870 rs1775735 chr10:32255846 A/G cg04359828 chr10:32216031 ARHGAP12 0.38 6.24 0.32 1.33e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs644799 0.544 rs56298021 chr11:95545113 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.66 9.7 0.47 9.45e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg06028605 chr16:24865363 SLC5A11 0.54 8.0 0.4 2.03e-14 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg24006582 chr15:45444508 DUOX1 -0.6 -8.67 -0.43 1.84e-16 Uric acid levels; LUSC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs9646944 0.501 rs10174323 chr2:103012781 C/A cg20060108 chr2:102954350 IL1RL1 0.48 6.51 0.34 2.73e-10 Blood protein levels; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.12 -0.48 3.46e-21 Electroencephalogram traits; LUSC cis rs9457247 0.967 rs382009 chr6:167403121 G/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.29e-11 Glomerular filtration rate (creatinine); LUSC cis rs2067615 0.579 rs1073261 chr12:107135942 A/G cg15890332 chr12:107067104 RFX4 0.34 6.21 0.32 1.59e-9 Heart rate; LUSC cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.36 0.37 1.48e-12 Cognitive ability; LUSC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg12463550 chr7:65579703 CRCP -0.45 -6.46 -0.33 3.62e-10 Aortic root size; LUSC cis rs11098499 0.909 rs1546502 chr4:120235898 A/G cg24375607 chr4:120327624 NA 0.81 11.98 0.55 9.13e-28 Corneal astigmatism; LUSC cis rs54211 0.808 rs5757608 chr22:39694622 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.59 5.92 0.31 7.96e-9 Sudden cardiac arrest; LUSC cis rs6700896 0.500 rs7518632 chr1:66103350 C/A cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.29 0.33 9.97e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs13221852 0.659 rs1554499 chr7:3415818 G/A cg21248987 chr7:3385318 SDK1 0.36 6.06 0.31 3.65e-9 Acute graft versus host disease in bone marrow transplantation (donor effect); LUSC trans rs7829975 0.688 rs6995407 chr8:8384647 C/G cg27411982 chr8:10470053 RP1L1 0.43 7.07 0.36 8.96e-12 Mood instability; LUSC cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg12863693 chr15:85201151 NMB -0.39 -8.18 -0.41 5.99e-15 Schizophrenia; LUSC cis rs62400317 0.859 rs6919813 chr6:45159177 C/T cg18551225 chr6:44695536 NA -0.45 -7.19 -0.37 4.17e-12 Total body bone mineral density; LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.89 0.55 2.01e-27 Prudent dietary pattern; LUSC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg26314531 chr2:26401878 FAM59B -0.68 -9.18 -0.45 4.53e-18 Gut microbiome composition (summer); LUSC trans rs2243480 1.000 rs781150 chr7:65480973 C/T cg10756647 chr7:56101905 PSPH 0.86 8.34 0.42 1.97e-15 Diabetic kidney disease; LUSC cis rs10761482 0.861 rs10761492 chr10:62108901 A/C cg18175470 chr10:62150864 ANK3 -0.5 -7.05 -0.36 1.05e-11 Schizophrenia; LUSC cis rs68170813 0.652 rs6976759 chr7:107158506 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg04369109 chr6:150039330 LATS1 -0.58 -8.6 -0.43 3.25e-16 Lung cancer; LUSC cis rs35146811 0.695 rs1623264 chr7:99811204 G/C cg19116668 chr7:99932089 PMS2L1 0.34 5.99 0.31 5.31e-9 Coronary artery disease; LUSC cis rs981844 0.712 rs1037649 chr4:154737796 G/A cg14289246 chr4:154710475 SFRP2 -0.45 -6.26 -0.32 1.15e-9 Response to statins (LDL cholesterol change); LUSC cis rs11971779 0.680 rs7801613 chr7:139039927 A/G cg07862535 chr7:139043722 LUC7L2 -0.49 -6.02 -0.31 4.62e-9 Diisocyanate-induced asthma; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00157987 chr14:65347345 NA -0.44 -6.08 -0.32 3.37e-9 Hepatitis; LUSC cis rs180358 0.588 rs1263167 chr11:116677723 A/G cg08985259 chr11:116699649 APOC3 0.3 5.92 0.31 7.82e-9 Multiple sclerosis (severity); LUSC cis rs7739264 0.544 rs6456266 chr6:19791284 C/T cg02404759 chr6:19790362 NA -0.44 -6.8 -0.35 4.9e-11 Endometriosis; LUSC cis rs921968 0.643 rs10187066 chr2:219514759 A/G cg02176678 chr2:219576539 TTLL4 0.6 10.96 0.51 4.43e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs1577917 1.000 rs35419329 chr6:86702291 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.49e-11 Response to antipsychotic treatment; LUSC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.43 6.1 0.32 2.92e-9 Height; LUSC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg16235748 chr6:149772707 ZC3H12D -0.28 -5.72 -0.3 2.31e-8 Dupuytren's disease; LUSC cis rs7264396 0.790 rs3787164 chr20:34228866 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.93 -0.48 1.58e-20 Total cholesterol levels; LUSC trans rs637571 0.528 rs11602769 chr11:65594139 T/C cg17712092 chr4:129076599 LARP1B -0.79 -11.65 -0.54 1.46e-26 Eosinophil percentage of white cells; LUSC cis rs9393692 0.645 rs2179152 chr6:26325888 T/C cg00631329 chr6:26305371 NA -0.55 -10.73 -0.51 2.79e-23 Educational attainment; LUSC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg06112835 chr11:68658793 MRPL21 0.52 8.2 0.41 5.38e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg15485101 chr11:133734466 NA 0.4 7.37 0.37 1.35e-12 Childhood ear infection; LUSC cis rs55883249 1.000 rs10495573 chr2:9712160 T/G cg23886495 chr2:9695866 ADAM17 0.5 5.76 0.3 1.92e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs427394 0.802 rs274718 chr5:6720988 G/T cg25011763 chr5:6727354 POLS -0.34 -5.77 -0.3 1.84e-8 Menopause (age at onset); LUSC cis rs17270561 0.609 rs9348692 chr6:25720812 A/G cg17691542 chr6:26056736 HIST1H1C 0.6 8.12 0.41 8.79e-15 Iron status biomarkers; LUSC cis rs4631830 0.896 rs7088225 chr10:51522120 T/C cg20129853 chr10:51489980 NA 0.34 6.87 0.35 3.13e-11 Prostate-specific antigen levels; LUSC cis rs5753618 0.539 rs5997933 chr22:31672752 A/C cg22777020 chr22:31556080 RNF185 -0.46 -5.82 -0.3 1.35e-8 Colorectal cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19163074 chr7:65112434 INTS4L2 0.5 6.91 0.35 2.51e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg08975724 chr8:8085496 FLJ10661 0.42 5.97 0.31 6.04e-9 Retinal vascular caliber; LUSC cis rs4900538 0.963 rs1190553 chr14:102915331 G/T cg18135206 chr14:102964638 TECPR2 -1.03 -21.06 -0.76 2.93e-63 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg21238619 chr17:78079768 GAA 0.4 7.51 0.38 5.43e-13 Yeast infection; LUSC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg27398817 chr8:82754497 SNX16 -0.67 -8.54 -0.42 4.97e-16 Diastolic blood pressure; LUSC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg15649852 chr7:65879115 NA 0.41 5.78 0.3 1.69e-8 Aortic root size; LUSC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.52 -0.38 5.02e-13 Personality dimensions; LUSC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg02569458 chr12:86230093 RASSF9 0.49 8.2 0.41 5.16e-15 Major depressive disorder; LUSC cis rs2279817 0.913 rs2270979 chr1:18023290 C/T cg21791023 chr1:18019539 ARHGEF10L 0.52 7.38 0.37 1.27e-12 Neuroticism; LUSC cis rs116988415 0.584 rs2269308 chr14:65244950 G/A cg25083366 chr14:65239357 SPTB 0.57 6.02 0.31 4.65e-9 Daytime sleep phenotypes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27576415 chr15:41709087 RTF1 0.43 6.27 0.32 1.1e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9905704 0.647 rs9898048 chr17:57108543 C/T cg12560992 chr17:57184187 TRIM37 0.59 10.02 0.48 7.54e-21 Testicular germ cell tumor; LUSC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg20821713 chr7:1055600 C7orf50 -0.52 -6.79 -0.35 5e-11 Bronchopulmonary dysplasia; LUSC trans rs2018683 0.707 rs917218 chr7:28975122 A/C cg19402173 chr7:128379420 CALU -0.46 -6.95 -0.36 1.96e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs4843747 0.671 rs28465438 chr16:88103714 G/A cg17633681 chr16:88106987 BANP 0.5 9.19 0.45 4.38e-18 Menopause (age at onset); LUSC cis rs9398803 0.713 rs6921183 chr6:126869029 A/T cg19875578 chr6:126661172 C6orf173 0.39 5.72 0.3 2.32e-8 Male-pattern baldness; LUSC cis rs1559088 0.948 rs12460195 chr19:33584479 G/A cg03563238 chr19:33554763 RHPN2 -0.41 -6.56 -0.34 2.09e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7178572 0.625 rs12905285 chr15:77845812 T/C cg22256960 chr15:77711686 NA -0.44 -7.07 -0.36 8.88e-12 Type 2 diabetes; LUSC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg12310025 chr6:25882481 NA -0.46 -7.75 -0.39 1.1e-13 Intelligence (multi-trait analysis); LUSC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg10909506 chr17:38081995 ORMDL3 0.33 5.95 0.31 6.59e-9 Self-reported allergy; LUSC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg14552801 chr7:65878734 NA 0.37 5.65 0.3 3.47e-8 Aortic root size; LUSC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg05025164 chr4:1340916 KIAA1530 0.42 6.42 0.33 4.65e-10 Obesity-related traits; LUSC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg03433033 chr1:76189801 ACADM 0.8 12.78 0.57 1e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg05729581 chr11:3078854 CARS -0.51 -7.65 -0.39 2.17e-13 Longevity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24327541 chr19:8570921 NA -0.57 -6.91 -0.35 2.48e-11 Bipolar disorder and schizophrenia; LUSC cis rs2742234 0.910 rs2505511 chr10:43641029 T/A cg02780029 chr10:43622663 RET -0.34 -6.17 -0.32 1.95e-9 Hirschsprung disease; LUSC cis rs11098499 0.863 rs3775845 chr4:120432447 T/C cg09307838 chr4:120376055 NA 0.75 10.98 0.51 3.78e-24 Corneal astigmatism; LUSC cis rs6429082 0.627 rs2016437 chr1:235539355 T/G cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.87 -0.35 3.11e-11 Adiposity; LUSC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg11663144 chr21:46675770 NA 0.43 7.52 0.38 5.26e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4604732 0.631 rs11490198 chr1:247625703 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs61931739 0.534 rs10844732 chr12:34037104 A/C cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 2.92e-25 Morning vs. evening chronotype; LUSC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.75 -0.35 6.58e-11 Lung cancer; LUSC cis rs3126085 0.935 rs2291770 chr1:152179792 G/C cg03465714 chr1:152285911 FLG -0.42 -5.85 -0.3 1.17e-8 Atopic dermatitis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09284703 chr19:36207534 MLL4;ZBTB32 0.77 6.34 0.33 7.32e-10 Cognitive performance; LUSC cis rs34779708 0.966 rs10827491 chr10:35427395 G/A cg04310649 chr10:35416472 CREM -0.42 -6.59 -0.34 1.74e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6906287 0.647 rs12194555 chr6:118819212 C/A cg21191810 chr6:118973309 C6orf204 0.32 5.74 0.3 2.16e-8 Electrocardiographic conduction measures; LUSC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg07424592 chr7:64974309 NA -0.63 -5.66 -0.3 3.26e-8 Diabetic kidney disease; LUSC cis rs11031096 0.655 rs34295904 chr11:4206701 C/A cg18678763 chr11:4115507 RRM1 -0.41 -5.77 -0.3 1.78e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9283706 0.673 rs2006323 chr5:66305992 T/C cg11590213 chr5:66331682 MAST4 0.45 6.75 0.35 6.45e-11 Coronary artery disease; LUSC cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1823874 1.000 rs1823874 chr15:100357435 T/C cg16400843 chr15:100339927 C15orf51 0.41 8.29 0.41 2.87e-15 IgG glycosylation; LUSC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs600626 0.636 rs11236517 chr11:75452721 T/C cg24262691 chr11:75473276 NA 0.5 6.77 0.35 5.8200000000000003e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.4 -7.62 -0.38 2.64e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs4925325 0.915 rs2427246 chr20:60517047 T/C cg06108461 chr20:60628389 TAF4 -0.66 -8.67 -0.43 1.91e-16 Obesity-related traits; LUSC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg14416269 chr4:6271139 WFS1 0.54 11.13 0.52 1.14e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs425277 1.000 rs262641 chr1:2104981 C/T cg03732007 chr1:2071316 PRKCZ -0.51 -8.51 -0.42 5.91e-16 Height; LUSC cis rs10208940 0.920 rs11886343 chr2:68750336 G/A cg12452813 chr2:68675892 NA 0.56 5.81 0.3 1.45e-8 Urate levels in lean individuals; LUSC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg13206674 chr6:150067644 NUP43 0.6 9.18 0.45 4.69e-18 Lung cancer; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC cis rs3741151 0.773 rs7110369 chr11:73160946 C/A cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg03433033 chr1:76189801 ACADM 0.8 12.18 0.55 1.76e-28 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1670533 1.000 rs6852155 chr4:1067638 T/G cg16405210 chr4:1374714 KIAA1530 -0.47 -5.88 -0.31 1.01e-8 Recombination rate (females); LUSC cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.15 0.36 5.38e-12 Rheumatoid arthritis; LUSC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg04944784 chr2:26401820 FAM59B -0.67 -9.4 -0.46 9.16e-19 Gut microbiome composition (summer); LUSC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg21665744 chr7:39171113 POU6F2 0.49 7.78 0.39 8.99e-14 IgG glycosylation; LUSC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg20887711 chr4:1340912 KIAA1530 0.44 6.69 0.34 9.7e-11 Obesity-related traits; LUSC cis rs9297145 0.724 rs6954584 chr7:98766930 G/A cg05967295 chr7:98741636 SMURF1 0.96 14.32 0.62 1.3e-36 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs6062509 0.965 rs2315007 chr20:62343845 T/C cg01176363 chr20:62369445 LIME1 -0.47 -7.14 -0.36 5.85e-12 Prostate cancer; LUSC cis rs9463078 0.683 rs1418433 chr6:44752568 C/T cg25276700 chr6:44698697 NA 0.29 5.74 0.3 2.14e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs10992471 0.580 rs12341093 chr9:95234182 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.68 -0.39 1.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg12011299 chr4:100065546 ADH4 0.72 11.13 0.52 1.13e-24 Alcohol dependence; LUSC cis rs2179367 0.600 rs11155654 chr6:149763137 G/A cg07828024 chr6:149772892 ZC3H12D -0.33 -5.71 -0.3 2.48e-8 Dupuytren's disease; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.58 9.81 0.47 3.86e-20 Lymphocyte counts; LUSC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg05805236 chr11:65401703 PCNXL3 0.37 5.84 0.3 1.26e-8 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs2179367 0.600 rs9498353 chr6:149760996 T/C cg07828024 chr6:149772892 ZC3H12D -0.35 -5.87 -0.31 1.03e-8 Dupuytren's disease; LUSC cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg11244672 chr19:19639970 YJEFN3 -0.55 -6.91 -0.35 2.49e-11 Bipolar disorder; LUSC cis rs72781680 1.000 rs72798417 chr2:24188656 C/T cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg19774624 chr17:42201019 HDAC5 0.71 10.31 0.49 7.74e-22 Total body bone mineral density; LUSC cis rs2197308 0.765 rs12370231 chr12:37917881 T/C cg13010199 chr12:38710504 ALG10B 0.71 10.95 0.51 4.69e-24 Morning vs. evening chronotype; LUSC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg08499158 chr17:42289980 UBTF 0.39 6.5 0.33 2.99e-10 Total body bone mineral density; LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.73 0.43 1.26e-16 Prudent dietary pattern; LUSC cis rs6545883 0.859 rs62149714 chr2:61603869 T/G cg15711740 chr2:61764176 XPO1 0.41 6.26 0.32 1.19e-9 Tuberculosis; LUSC cis rs9948 0.655 rs17119562 chr2:97381844 G/C cg01990225 chr2:97406019 LMAN2L -1.09 -7.42 -0.38 9.98e-13 Erectile dysfunction and prostate cancer treatment; LUSC cis rs926938 0.527 rs360667 chr1:115481451 C/G cg01522456 chr1:115632236 TSPAN2 0.42 6.6 0.34 1.59e-10 Autism; LUSC trans rs61931739 0.517 rs11612493 chr12:34114272 A/C cg26384229 chr12:38710491 ALG10B 0.68 10.98 0.51 3.73e-24 Morning vs. evening chronotype; LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs6545883 0.895 rs2177961 chr2:61560264 T/C cg15711740 chr2:61764176 XPO1 0.46 7.24 0.37 3.14e-12 Tuberculosis; LUSC cis rs11711311 0.955 rs34458493 chr3:113396473 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 5.96 0.31 6.32e-9 IgG glycosylation; LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg25072359 chr17:41440525 NA 0.65 9.08 0.45 9.46e-18 Menopause (age at onset); LUSC cis rs2742417 1.000 rs2673025 chr3:45760483 A/G cg04837898 chr3:45731254 SACM1L -0.37 -6.11 -0.32 2.79e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg17063962 chr7:91808500 NA 0.58 9.28 0.45 2.15e-18 Breast cancer; LUSC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg05084668 chr3:125655381 ALG1L -0.49 -6.9 -0.35 2.55e-11 Blood pressure (smoking interaction); LUSC trans rs7939886 0.920 rs7940563 chr11:55875133 C/T cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg24250549 chr1:154909240 PMVK 0.64 10.4 0.49 3.92e-22 Prostate cancer; LUSC cis rs1595825 1.000 rs1440090 chr2:198879297 T/G cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs1595825 0.891 rs59990242 chr2:198895868 G/A cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs11148252 0.514 rs1886539 chr13:52726090 C/T cg00495681 chr13:53174319 NA 0.42 6.07 0.32 3.38e-9 Lewy body disease; LUSC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg24829409 chr8:58192753 C8orf71 -0.47 -5.68 -0.3 2.89e-8 Developmental language disorder (linguistic errors); LUSC cis rs2692947 0.726 rs13009727 chr2:96769883 C/G cg22654517 chr2:96458247 NA -0.35 -6.72 -0.35 7.65e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs727505 0.607 rs17387591 chr7:124799471 A/G cg23710748 chr7:124431027 NA -0.37 -6.56 -0.34 2.05e-10 Lewy body disease; LUSC cis rs859767 0.704 rs9287437 chr2:135357502 C/T cg12500956 chr2:135428796 TMEM163 -0.27 -6.35 -0.33 7.13e-10 Neuroticism; LUSC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg12463550 chr7:65579703 CRCP -0.42 -6.17 -0.32 1.98e-9 Aortic root size; LUSC cis rs4964805 0.626 rs869993 chr12:104175138 A/T cg02344784 chr12:104178138 NT5DC3 0.45 7.17 0.37 4.76e-12 Attention deficit hyperactivity disorder; LUSC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg13939156 chr17:80058883 NA -0.33 -6.42 -0.33 4.68e-10 Life satisfaction; LUSC cis rs2969070 0.831 rs10279360 chr7:2503998 T/C cg03277898 chr7:2518824 NA -0.27 -5.82 -0.3 1.35e-8 Diastolic blood pressure; LUSC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg11812906 chr14:75593930 NEK9 -0.63 -10.39 -0.49 4.35e-22 Height; LUSC cis rs12711979 0.765 rs6705742 chr2:3820672 C/T cg17052675 chr2:3827356 NA -0.57 -11.33 -0.53 2.12e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.49 -9.77 -0.47 5.35e-20 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs28493229 0.522 rs17713068 chr19:41270055 A/C cg21869046 chr19:41225005 ITPKC 0.49 6.71 0.34 8.51e-11 Kawasaki disease; LUSC cis rs1577917 0.785 rs1885607 chr6:86394905 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.53 8.53 0.42 5.12e-16 Response to antipsychotic treatment; LUSC cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg21385522 chr1:16154831 NA 0.73 11.69 0.54 1.03e-26 Dilated cardiomyopathy; LUSC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg08470875 chr2:26401718 FAM59B -0.71 -9.62 -0.47 1.64e-19 Gut microbiome composition (summer); LUSC cis rs262147 0.610 rs2657363 chr7:158684273 C/T cg11984989 chr7:158649758 WDR60 1.01 8.57 0.42 4.02e-16 Hippocampal volume; LUSC cis rs17767294 0.708 rs113741085 chr6:27849982 C/A cg08851530 chr6:28072375 NA 1.18 7.77 0.39 9.45e-14 Parkinson's disease; LUSC cis rs2857891 0.817 rs2638102 chr11:6968610 T/C cg04053776 chr11:6947353 ZNF215 0.42 5.94 0.31 6.99e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg08085267 chr17:45401833 C17orf57 0.54 8.85 0.44 5.16e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs193541 0.556 rs30024 chr5:122285160 A/G cg19077854 chr5:122220652 SNX24 0.4 8.57 0.42 3.96e-16 Glucose homeostasis traits; LUSC cis rs8114671 0.562 rs6058137 chr20:33475074 G/A cg24642439 chr20:33292090 TP53INP2 0.45 6.45 0.33 4.04e-10 Height; LUSC cis rs804280 0.662 rs11784693 chr8:11610674 C/T cg26752888 chr8:11627280 NEIL2 0.45 6.03 0.31 4.36e-9 Myopia (pathological); LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.6 0.38 3.03e-13 Bipolar disorder; LUSC cis rs6005807 0.719 rs16986398 chr22:28815629 A/C cg12565055 chr22:29076175 TTC28 0.53 5.8 0.3 1.56e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs9326248 0.861 rs1871757 chr11:117030581 A/T cg16524733 chr11:117070046 TAGLN 0.37 5.93 0.31 7.36e-9 Blood protein levels; LUSC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg02421172 chr7:1938701 MAD1L1 0.43 5.67 0.3 3.02e-8 Bipolar disorder; LUSC cis rs12618769 0.597 rs72821946 chr2:99142411 G/C cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs897984 0.645 rs58726213 chr16:31044683 A/G cg02466173 chr16:30829666 NA -0.52 -10.2 -0.49 1.98e-21 Dementia with Lewy bodies; LUSC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg00255919 chr5:131827918 IRF1 0.43 8.25 0.41 3.62e-15 Asthma (sex interaction); LUSC cis rs6121246 0.567 rs6120815 chr20:30184866 T/C cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg26338869 chr17:61819248 STRADA 0.42 5.96 0.31 6.53e-9 Prudent dietary pattern; LUSC cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.85 0.3 1.18e-8 Breast cancer; LUSC cis rs1348850 0.597 rs4893964 chr2:178447658 G/T cg23306229 chr2:178417860 TTC30B 0.54 6.06 0.31 3.69e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.0 0.52 3.07e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1577917 0.958 rs11756615 chr6:86679835 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.61 -0.43 2.96e-16 Response to antipsychotic treatment; LUSC cis rs17155006 0.664 rs451252 chr7:107738948 G/A cg05962710 chr7:107745446 LAMB4 -0.36 -6.3 -0.33 9.63e-10 Pneumococcal bacteremia; LUSC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.6 -0.34 1.64e-10 High light scatter reticulocyte count; LUSC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg25039879 chr17:56429692 SUPT4H1 0.7 9.56 0.46 2.65e-19 Cognitive test performance; LUSC cis rs10761482 0.817 rs4948404 chr10:62108202 C/T cg18175470 chr10:62150864 ANK3 -0.51 -7.31 -0.37 2e-12 Schizophrenia; LUSC trans rs7819412 0.745 rs6601569 chr8:11073578 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.4 -0.38 1.13e-12 Triglycerides; LUSC cis rs2078087 0.522 rs503243 chr1:183222013 A/G cg13843938 chr1:183241246 NMNAT2 -0.37 -6.08 -0.32 3.32e-9 Obesity-related traits; LUSC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg09849774 chr21:43526787 UMODL1;C21orf128 -0.45 -6.96 -0.36 1.84e-11 IgG glycosylation; LUSC cis rs7100689 0.646 rs11202721 chr10:82135762 G/A cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.53e-9 Breast cancer; LUSC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg05313129 chr8:58192883 C8orf71 -0.51 -5.65 -0.3 3.44e-8 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC trans rs72674100 1.000 rs76587581 chr4:97932962 A/G cg09670535 chr1:18959427 PAX7 -0.64 -6.14 -0.32 2.39e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7572733 0.534 rs1401092 chr2:198792320 C/A cg00792783 chr2:198669748 PLCL1 -0.44 -5.86 -0.31 1.13e-8 Dermatomyositis; LUSC cis rs7512552 0.839 rs2264418 chr1:150368579 G/A cg15654264 chr1:150340011 RPRD2 0.61 10.09 0.48 4.38e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2762353 0.935 rs1359232 chr6:25809716 C/A cg03264133 chr6:25882463 NA 0.42 7.26 0.37 2.74e-12 Blood metabolite levels; LUSC cis rs7605827 0.930 rs1469016 chr2:15687627 A/G cg19274914 chr2:15703543 NA 0.46 8.83 0.44 5.83e-17 Educational attainment (years of education); LUSC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg20607287 chr7:12443886 VWDE -0.61 -6.43 -0.33 4.45e-10 Coronary artery disease; LUSC cis rs11122272 0.701 rs7414807 chr1:231476874 G/A cg06096015 chr1:231504339 EGLN1 0.53 9.08 0.45 9.57e-18 Hemoglobin concentration; LUSC cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg23788917 chr6:8435910 SLC35B3 0.51 7.55 0.38 4.28e-13 Motion sickness; LUSC cis rs6690583 0.573 rs7547317 chr1:85456961 T/G cg11262906 chr1:85462892 MCOLN2 0.7 6.47 0.33 3.56e-10 Serum sulfate level; LUSC trans rs877282 0.755 rs2486578 chr10:785227 C/T cg22713356 chr15:30763199 NA -0.88 -12.76 -0.57 1.24e-30 Uric acid levels; LUSC cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg13010199 chr12:38710504 ALG10B -0.64 -11.02 -0.52 2.75e-24 Heart rate; LUSC trans rs7824557 0.628 rs7815802 chr8:11190647 G/C cg15556689 chr8:8085844 FLJ10661 0.46 6.91 0.35 2.5e-11 Retinal vascular caliber; LUSC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.4 5.93 0.31 7.6e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg04518342 chr5:131593106 PDLIM4 0.41 7.89 0.4 4.4e-14 Blood metabolite levels; LUSC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg03929089 chr4:120376271 NA -0.94 -16.17 -0.66 7.44e-44 Height; LUSC cis rs9393777 0.623 rs9358947 chr6:26479000 G/A cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg13498757 chr1:152161927 NA 0.35 5.88 0.31 1e-8 Inflammatory skin disease; LUSC cis rs1577917 0.740 rs2758845 chr6:86334848 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.79 -0.39 8.69e-14 Response to antipsychotic treatment; LUSC cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg00677455 chr12:58241039 CTDSP2 -0.42 -6.12 -0.32 2.69e-9 Multiple sclerosis; LUSC cis rs34779708 0.966 rs34605125 chr10:35411246 A/G cg04310649 chr10:35416472 CREM -0.42 -6.61 -0.34 1.49e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs861020 1.000 rs642961 chr1:209989270 A/G cg09163369 chr1:210001066 C1orf107 0.52 5.88 0.31 9.88e-9 Orofacial clefts; LUSC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg15664640 chr17:80829946 TBCD -0.73 -12.72 -0.57 1.67e-30 Breast cancer; LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg00814883 chr7:100076585 TSC22D4 -0.76 -9.74 -0.47 6.61e-20 Platelet count; LUSC cis rs7833986 0.534 rs10504198 chr8:57006254 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.2 0.56 1.4e-28 Height; LUSC cis rs6570726 0.516 rs10484700 chr6:145728933 C/T cg23711669 chr6:146136114 FBXO30 0.45 7.07 0.36 9.04e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs12410462 0.581 rs113827839 chr1:227547180 C/T cg10327440 chr1:227177885 CDC42BPA -0.66 -6.47 -0.33 3.44e-10 Major depressive disorder; LUSC cis rs28830936 0.510 rs11858843 chr15:42092915 C/A cg17847044 chr15:42102381 MAPKBP1 -0.37 -9.16 -0.45 5.43e-18 Diastolic blood pressure; LUSC cis rs511515 1 rs511515 chr6:33541507 A/G cg07679836 chr6:33548423 BAK1 0.51 8.09 0.4 1.12e-14 Eosinophil counts;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC cis rs478304 0.651 rs11537193 chr11:65500003 A/C cg10518572 chr11:65560635 OVOL1 -0.25 -5.75 -0.3 1.97e-8 Acne (severe); LUSC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.77 0.3 1.82e-8 Tonsillectomy; LUSC cis rs9916302 0.904 rs7221875 chr17:37543328 G/A cg15445000 chr17:37608096 MED1 -0.4 -6.85 -0.35 3.46e-11 Glomerular filtration rate (creatinine); LUSC cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.82 -0.35 4.33e-11 Monocyte percentage of white cells; LUSC cis rs7824557 0.527 rs2736305 chr8:11237773 T/C cg21775007 chr8:11205619 TDH -0.64 -9.95 -0.48 1.39e-20 Retinal vascular caliber; LUSC cis rs17292804 0.527 rs12887734 chr14:104046834 G/T cg01849466 chr14:104193079 ZFYVE21 -0.45 -6.38 -0.33 5.97e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs5762813 0.524 rs5752815 chr22:29230733 C/A cg02153584 chr22:29168773 CCDC117 0.54 6.36 0.33 6.54e-10 Hematocrit;Hemoglobin concentration; LUSC trans rs6598955 0.671 rs11247884 chr1:26577338 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs7829975 0.774 rs13259216 chr8:8673601 A/C cg08975724 chr8:8085496 FLJ10661 0.52 7.7 0.39 1.55e-13 Mood instability; LUSC cis rs10751667 0.961 rs7395928 chr11:952605 T/G ch.11.42038R chr11:967971 AP2A2 0.54 8.19 0.41 5.79e-15 Alzheimer's disease (late onset); LUSC cis rs748404 0.723 rs512431 chr15:43541939 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.48 -7.6 -0.38 3.07e-13 Lung cancer; LUSC cis rs1577917 0.916 rs12203358 chr6:86603224 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.97 -0.36 1.7e-11 Response to antipsychotic treatment; LUSC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg17173187 chr15:85201210 NMB 0.37 6.55 0.34 2.19e-10 Schizophrenia; LUSC trans rs72792513 1.000 rs76240659 chr2:22916507 T/G cg05844895 chr16:88969569 CBFA2T3 0.52 6.07 0.32 3.4e-9 Hepatitis B; LUSC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg02269571 chr22:50332266 NA 0.59 8.71 0.43 1.44e-16 Schizophrenia; LUSC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg26597838 chr10:835615 NA 0.98 14.13 0.61 7.04e-36 Eosinophil percentage of granulocytes; LUSC cis rs9325144 0.581 rs2653758 chr12:38946233 G/T cg13010199 chr12:38710504 ALG10B -0.54 -8.54 -0.42 4.93e-16 Morning vs. evening chronotype; LUSC cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg08999081 chr20:33150536 PIGU 0.38 6.9 0.35 2.68e-11 Height; LUSC trans rs3857536 0.740 rs7745163 chr6:66889936 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.26 -0.32 1.19e-9 Blood trace element (Cu levels); LUSC cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg16339924 chr4:17578868 LAP3 0.54 8.11 0.41 9.69e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.42e-17 Prudent dietary pattern; LUSC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg07636037 chr3:49044803 WDR6 1.03 17.94 0.7 7.26e-51 Parkinson's disease; LUSC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.09e-30 Aortic root size; LUSC trans rs11935423 0.778 rs28647519 chr4:100500775 C/T cg02164153 chr5:172068145 NEURL1B -0.47 -6.05 -0.31 3.97e-9 Gut microbiome composition (summer); LUSC cis rs8078723 0.866 rs11078934 chr17:38189793 C/T cg17467752 chr17:38218738 THRA 0.81 13.63 0.6 6.01e-34 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs11122272 0.735 rs2486745 chr1:231505717 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.83 -0.47 3.46e-20 Hemoglobin concentration; LUSC cis rs4891159 0.548 rs12454625 chr18:74128751 A/G cg24786174 chr18:74118243 ZNF516 0.97 21.74 0.77 6.65e-66 Longevity; LUSC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg12908607 chr1:44402522 ARTN -0.49 -7.59 -0.38 3.15e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg26384229 chr12:38710491 ALG10B -0.82 -13.93 -0.61 4.23e-35 Bladder cancer; LUSC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg15320075 chr8:145703422 NA -0.44 -6.98 -0.36 1.62e-11 Age at first birth; LUSC cis rs2658782 0.951 rs72972364 chr11:93122128 C/T cg15737290 chr11:93063684 CCDC67 -0.62 -7.3 -0.37 2.12e-12 Pulmonary function decline; LUSC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg27535305 chr1:53392650 SCP2 -0.38 -6.97 -0.36 1.7e-11 Monocyte count; LUSC cis rs7828089 0.522 rs4872484 chr8:22255859 C/T cg12081754 chr8:22256438 SLC39A14 0.87 13.85 0.6 8.99e-35 Verbal declarative memory; LUSC cis rs59698941 0.943 rs55767930 chr5:132203952 G/A cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.57e-11 Apolipoprotein A-IV levels; LUSC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 1.000 rs11213973 chr11:111538903 A/T cg19812747 chr11:111475976 SIK2 -0.49 -6.8 -0.35 4.81e-11 Primary sclerosing cholangitis; LUSC cis rs4654899 0.865 rs12130841 chr1:21067051 C/T cg01072550 chr1:21505969 NA -0.47 -7.04 -0.36 1.1e-11 Superior frontal gyrus grey matter volume; LUSC trans rs9929218 0.953 rs3118227 chr16:68734855 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -12.19 -0.55 1.55e-28 Colorectal cancer; LUSC cis rs9443189 0.527 rs775059 chr6:76370130 G/T cg01950844 chr6:76311363 SENP6 0.67 6.69 0.34 9.16e-11 Prostate cancer; LUSC trans rs6600671 1.000 rs1986111 chr1:121204788 C/T cg00646200 chr1:148855367 NA 0.46 7.31 0.37 1.94e-12 Hip geometry; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25411849 chr6:89855994 PM20D2 -0.54 -6.87 -0.35 3.13e-11 Bipolar disorder and schizophrenia; LUSC cis rs7520050 0.966 rs785479 chr1:46492144 C/T cg06784218 chr1:46089804 CCDC17 -0.29 -5.66 -0.3 3.22e-8 Red blood cell count;Reticulocyte count; LUSC trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg15704280 chr7:45808275 SEPT13 0.67 7.4 0.38 1.14e-12 Axial length; LUSC cis rs9868809 0.772 rs28452701 chr3:48708575 C/T cg00383909 chr3:49044727 WDR6 1.09 9.27 0.45 2.41e-18 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg27266027 chr21:40555129 PSMG1 0.41 5.98 0.31 5.88e-9 Cognitive function; LUSC cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.48 -7.38 -0.37 1.3e-12 Colorectal cancer; LUSC cis rs2540226 0.935 rs2716729 chr2:39954770 G/A cg23576258 chr2:39999331 THUMPD2 0.34 5.67 0.3 3.09e-8 Personality dimensions; LUSC cis rs9549367 0.713 rs556990 chr13:113845059 T/C cg18105134 chr13:113819100 PROZ 0.65 9.62 0.47 1.65e-19 Platelet distribution width; LUSC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs11971779 0.523 rs10279160 chr7:139090761 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs11098499 0.863 rs3775849 chr4:120450908 G/C cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC trans rs17685 0.784 rs1637043 chr7:75699099 G/A cg19862616 chr7:65841803 NCRNA00174 1.13 19.75 0.73 4.46e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs500891 0.553 rs3798884 chr6:84136112 C/A cg08257003 chr6:84140564 ME1 0.37 9.17 0.45 5.06e-18 Platelet-derived growth factor BB levels; LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg11645453 chr3:52864694 ITIH4 0.35 7.99 0.4 2.28e-14 Bipolar disorder; LUSC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg27532560 chr4:187881888 NA -0.39 -6.39 -0.33 5.65e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg05132306 chr1:1846340 CALML6 -0.34 -8.55 -0.42 4.62e-16 Body mass index; LUSC cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs752010 0.714 rs6600384 chr1:42085141 A/G cg06885757 chr1:42089581 HIVEP3 -0.46 -9.73 -0.47 7.07e-20 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs6582630 0.538 rs12304844 chr12:38335870 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.46 -0.38 7.41e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs1113500 0.836 rs1618973 chr1:108586767 T/C cg11967332 chr1:108735228 SLC25A24 -0.38 -5.81 -0.3 1.47e-8 Growth-regulated protein alpha levels; LUSC cis rs35883536 0.631 rs2783704 chr1:101040652 T/A cg06223162 chr1:101003688 GPR88 0.49 9.35 0.46 1.26e-18 Monocyte count; LUSC cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs7659604 0.540 rs67150579 chr4:122704331 T/A cg06713675 chr4:122721982 EXOSC9 0.39 6.36 0.33 6.57e-10 Type 2 diabetes; LUSC cis rs11190604 1.000 rs3750630 chr10:102275780 A/G cg23241863 chr10:102295624 HIF1AN 0.48 6.0 0.31 5.1e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9303401 0.659 rs3809724 chr17:57061238 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.28 0.56 7.28e-29 Cognitive test performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13677111 chr13:37574825 ALG5;EXOSC8 -0.42 -6.29 -0.33 1.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6700559 0.740 rs4072554 chr1:200649366 A/G cg07804481 chr1:200639085 DDX59 0.41 5.77 0.3 1.85e-8 Coronary artery disease; LUSC cis rs4953076 0.573 rs13008237 chr2:44404902 A/G cg08134877 chr2:44394819 PPM1B 0.41 5.83 0.3 1.3e-8 Height; LUSC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg23630131 chr7:65973040 NA -0.21 -5.91 -0.31 8.46e-9 Aortic root size; LUSC cis rs2235649 0.789 rs9929803 chr16:1852748 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.44 -6.02 -0.31 4.57e-9 Blood metabolite levels; LUSC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg24531977 chr5:56204891 C5orf35 -1.1 -16.2 -0.66 5.91e-44 Initial pursuit acceleration; LUSC trans rs2392780 0.667 rs424281 chr8:128339426 G/A cg10195415 chr17:73887371 TRIM65 0.42 6.65 0.34 1.18e-10 Breast cancer (early onset); LUSC cis rs96067 0.772 rs1033891 chr1:36608402 A/G cg24686825 chr1:36642396 MAP7D1 -0.57 -7.66 -0.39 2.05e-13 Corneal structure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27449864 chr7:73133982 STX1A -0.41 -6.22 -0.32 1.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.16 0.77 1.43e-67 Prudent dietary pattern; LUSC cis rs6076065 0.748 rs2295239 chr20:23387550 C/T cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg26924012 chr15:45694286 SPATA5L1 -1.12 -20.18 -0.74 9.3e-60 Homoarginine levels; LUSC cis rs9399401 0.667 rs34018047 chr6:142790873 G/C cg04461802 chr6:142623433 GPR126 0.46 5.92 0.31 7.8e-9 Chronic obstructive pulmonary disease; LUSC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.64 0.57 3.49e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17270561 0.609 rs4131670 chr6:25738619 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC cis rs4595586 0.679 rs4768471 chr12:39325960 G/A cg26384229 chr12:38710491 ALG10B 0.46 6.4 0.33 5.21e-10 Morning vs. evening chronotype; LUSC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg09365446 chr1:150670422 GOLPH3L 0.49 7.26 0.37 2.73e-12 Melanoma; LUSC cis rs7107174 1.000 rs7107174 chr11:77997936 C/T cg02023728 chr11:77925099 USP35 0.49 6.92 0.35 2.39e-11 Testicular germ cell tumor; LUSC cis rs7582720 1.000 rs72934751 chr2:203747522 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1799949 0.587 rs1824890 chr17:41421904 T/C cg23758822 chr17:41437982 NA 1.02 15.44 0.65 5.55e-41 Menopause (age at onset); LUSC cis rs9473147 0.543 rs9349417 chr6:47580657 A/G cg20196966 chr6:47445060 CD2AP 0.43 6.08 0.32 3.24e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs6495122 0.501 rs7167261 chr15:75343807 T/C cg09165964 chr15:75287851 SCAMP5 -0.47 -6.84 -0.35 3.69e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs500891 0.553 rs7770573 chr6:84137756 G/T cg08257003 chr6:84140564 ME1 0.37 9.17 0.45 5.06e-18 Platelet-derived growth factor BB levels; LUSC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg26408565 chr15:76604113 ETFA -0.49 -7.9 -0.4 4.05e-14 Blood metabolite levels; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg27588902 chr6:42928151 GNMT -0.27 -5.94 -0.31 7.29e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg00343986 chr7:65444356 GUSB 0.44 6.3 0.33 9.48e-10 Aortic root size; LUSC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 13.51 0.59 1.71e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg26408565 chr15:76604113 ETFA -0.5 -8.0 -0.4 2.04e-14 Blood metabolite levels; LUSC cis rs694739 0.628 rs617051 chr11:64133638 C/A cg26898376 chr11:64110657 CCDC88B 0.33 6.2 0.32 1.67e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs10986311 0.862 rs11791290 chr9:127096347 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.81 0.35 4.45e-11 Vitiligo; LUSC cis rs9300255 0.739 rs1980252 chr12:123745178 C/G cg05973401 chr12:123451056 ABCB9 0.52 6.49 0.33 3.19e-10 Neutrophil percentage of white cells; LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03934478 chr11:495069 RNH1 0.82 9.83 0.47 3.29e-20 Body mass index; LUSC cis rs6545883 0.868 rs2427885 chr2:61816777 A/G cg15711740 chr2:61764176 XPO1 -0.47 -7.41 -0.38 1.06e-12 Tuberculosis; LUSC cis rs9486719 1.000 rs28623445 chr6:96899116 G/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg08219700 chr8:58056026 NA 0.7 7.95 0.4 2.95e-14 Developmental language disorder (linguistic errors); LUSC cis rs7615316 0.779 rs6440078 chr3:142070495 C/T cg16271453 chr3:142027066 XRN1 -0.41 -7.19 -0.37 4.4e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg16586182 chr3:47516702 SCAP 0.52 8.13 0.41 8.41e-15 Colorectal cancer; LUSC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg27398817 chr8:82754497 SNX16 -0.47 -6.36 -0.33 6.47e-10 Diastolic blood pressure; LUSC cis rs11864453 0.793 rs7197453 chr16:72079127 G/C cg23815491 chr16:72088622 HP 0.37 6.54 0.34 2.28e-10 Fibrinogen levels; LUSC cis rs3096299 0.746 rs9931120 chr16:89501357 A/G cg08392591 chr16:89556376 ANKRD11 0.39 5.72 0.3 2.42e-8 Multiple myeloma (IgH translocation); LUSC trans rs72674100 0.737 rs2865752 chr4:97992784 T/C cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg15744005 chr10:104629667 AS3MT -0.39 -7.94 -0.4 3.09e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2046867 0.818 rs34582798 chr3:72882778 A/C cg25664220 chr3:72788482 NA -0.69 -11.4 -0.53 1.19e-25 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg22467129 chr15:76604101 ETFA -0.46 -7.26 -0.37 2.73e-12 Blood metabolite levels; LUSC cis rs9420 0.961 rs11606396 chr11:57435211 C/T cg23127183 chr11:57508653 C11orf31 -0.58 -8.85 -0.44 5.14e-17 Schizophrenia; LUSC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg13393036 chr8:95962371 TP53INP1 -0.52 -11.05 -0.52 2.05e-24 Type 2 diabetes; LUSC cis rs2239815 0.515 rs12170231 chr22:29237824 C/T cg02153584 chr22:29168773 CCDC117 0.55 6.34 0.33 7.34e-10 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs7582180 0.614 rs1530031 chr2:101009326 T/C cg08017756 chr2:100939284 LONRF2 -0.43 -8.06 -0.4 1.4e-14 Intelligence (multi-trait analysis); LUSC cis rs1692580 0.840 rs262679 chr1:2169792 C/T cg24578937 chr1:2090814 PRKCZ 0.38 7.69 0.39 1.61e-13 Coronary artery disease; LUSC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9807989 0.507 rs1420105 chr2:103035119 A/G cg03938978 chr2:103052716 IL18RAP 0.36 6.99 0.36 1.53e-11 Asthma; LUSC cis rs10752881 0.967 rs12404594 chr1:182988027 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.48 0.5 2.07e-22 Colorectal cancer; LUSC trans rs8002861 0.967 rs9533690 chr13:44480598 T/C cg12856521 chr11:46389249 DGKZ 0.41 6.38 0.33 6.02e-10 Leprosy; LUSC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg04176532 chr22:50317003 CRELD2 -0.4 -5.78 -0.3 1.71e-8 Schizophrenia; LUSC cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.06 0.36 9.98e-12 Rheumatoid arthritis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15104066 chr12:90102578 LOC338758 -0.37 -6.04 -0.31 4e-9 Triglycerides; LUSC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg17279839 chr7:150038598 RARRES2 0.44 7.02 0.36 1.24e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs3857536 0.813 rs1891600 chr6:66941645 G/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs7712401 0.601 rs386602 chr5:122321957 T/G cg19077854 chr5:122220652 SNX24 -0.44 -9.58 -0.46 2.28e-19 Mean platelet volume; LUSC cis rs12681287 0.640 rs8635 chr8:87479810 C/T cg27223183 chr8:87520930 FAM82B -0.52 -6.97 -0.36 1.74e-11 Caudate activity during reward; LUSC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg17385448 chr1:15911702 AGMAT 0.37 6.32 0.33 8.16e-10 Systolic blood pressure; LUSC trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg21153622 chr11:89784906 NA -0.39 -6.16 -0.32 2.13e-9 HDL cholesterol; LUSC cis rs3741151 0.773 rs73542976 chr11:73127471 A/G cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9560113 0.919 rs11069896 chr13:112178887 C/T cg14154082 chr13:112174009 NA 0.38 7.78 0.39 9e-14 Menarche (age at onset); LUSC trans rs800082 1.000 rs9289678 chr3:144307096 C/T cg24215973 chr2:240111563 HDAC4 0.47 7.23 0.37 3.33e-12 Smoking behavior; LUSC cis rs12422267 0.536 rs11246933 chr12:132610314 G/A cg09764611 chr12:132620959 NA -0.56 -8.07 -0.4 1.24e-14 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg13531842 chr10:38383804 ZNF37A -0.48 -7.42 -0.38 9.51e-13 Extrinsic epigenetic age acceleration; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs12618769 0.597 rs3754881 chr2:99132093 G/A cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs62103177 0.564 rs3930043 chr18:77723832 G/A cg02751453 chr18:77725136 HSBP1L1 -0.47 -6.17 -0.32 1.95e-9 Opioid sensitivity; LUSC cis rs17824933 0.848 rs11230560 chr11:60771077 G/A cg16817237 chr11:60793675 NA 0.39 6.3 0.33 9.26e-10 Multiple sclerosis; LUSC cis rs76878669 0.561 rs7115577 chr11:66172258 G/T cg18002602 chr11:66138449 SLC29A2 -0.46 -8.1 -0.41 1.02e-14 Educational attainment (years of education); LUSC cis rs2219968 0.798 rs4397393 chr8:78937569 G/C cg00738934 chr8:78996279 NA -0.42 -7.55 -0.38 4.31e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg08048268 chr3:133502702 NA -0.46 -8.79 -0.43 7.92e-17 Iron status biomarkers; LUSC cis rs921968 0.541 rs2710246 chr2:219533894 C/T cg02176678 chr2:219576539 TTLL4 0.66 12.7 0.57 2.1000000000000002e-30 Mean corpuscular hemoglobin concentration; LUSC cis rs10761482 0.861 rs4245587 chr10:62101589 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs1801251 0.711 rs778339 chr2:233739678 T/C cg08000102 chr2:233561755 GIGYF2 -0.5 -7.69 -0.39 1.61e-13 Coronary artery disease; LUSC trans rs13011075 0.844 rs17530191 chr2:68621338 G/T cg14221825 chr19:46271408 SIX5 0.42 6.04 0.31 4.16e-9 Mean corpuscular volume; LUSC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg13047869 chr3:10149882 C3orf24 0.56 7.73 0.39 1.24e-13 Alzheimer's disease; LUSC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg18252515 chr7:66147081 NA -1.21 -13.48 -0.59 2.22e-33 Diabetic kidney disease; LUSC cis rs6541297 1.000 rs6541296 chr1:230281953 A/G cg05784532 chr1:230284198 GALNT2 0.54 8.04 0.4 1.6e-14 Coronary artery disease; LUSC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg11764359 chr7:65958608 NA 0.68 10.89 0.51 7.59e-24 Aortic root size; LUSC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.55 0.42 4.57e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12474201 0.588 rs3768719 chr2:46987935 T/G cg06386533 chr2:46925753 SOCS5 0.48 6.93 0.35 2.15e-11 Height; LUSC cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.2e-12 Schizophrenia; LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs977987 0.800 rs12922951 chr16:75355096 C/G cg03315344 chr16:75512273 CHST6 0.53 10.12 0.48 3.61e-21 Dupuytren's disease; LUSC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.17 -0.41 6.52e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2694528 1.000 rs929780 chr5:60189026 C/G cg11474532 chr5:59995715 DEPDC1B -0.71 -6.77 -0.35 5.85e-11 Parkinson's disease; LUSC cis rs79149102 0.579 rs3812943 chr15:75312715 C/G cg17294928 chr15:75287854 SCAMP5 -0.76 -6.68 -0.34 1.01e-10 Lung cancer; LUSC cis rs477692 0.905 rs509041 chr10:131424948 A/G cg05714579 chr10:131428358 MGMT 0.52 7.97 0.4 2.46e-14 Response to temozolomide; LUSC trans rs10506458 0.915 rs2013050 chr12:63394310 C/T cg22491629 chr6:157744540 C6orf35 -0.92 -10.94 -0.51 5.17e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg03433033 chr1:76189801 ACADM 0.81 12.95 0.58 2.24e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15541040 chr2:3486749 NA -0.58 -9.1 -0.45 8.15e-18 Neurofibrillary tangles; LUSC cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg01028140 chr2:1542097 TPO -0.6 -7.98 -0.4 2.45e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs6496667 0.683 rs2589973 chr15:90892293 C/T cg10434728 chr15:90938212 IQGAP1 0.34 6.35 0.33 6.96e-10 Rheumatoid arthritis; LUSC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg21984481 chr17:79567631 NPLOC4 -0.59 -11.22 -0.52 5.11e-25 Eye color traits; LUSC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg08677398 chr8:58056175 NA 0.52 6.4 0.33 5.13e-10 Developmental language disorder (linguistic errors); LUSC cis rs2361718 0.631 rs4889989 chr17:78151860 C/G cg20811857 chr17:78079795 GAA 0.34 6.2 0.32 1.62e-9 Yeast infection; LUSC cis rs2836633 0.895 rs2836598 chr21:40024758 C/G cg12884169 chr21:40033163 ERG 0.6 11.94 0.55 1.36e-27 Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02510388 chr3:182511451 ATP11B 0.68 6.4 0.33 5.34e-10 Cognitive performance; LUSC cis rs28374715 0.578 rs8036026 chr15:41630499 C/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -22.54 -0.78 4.9e-69 Ulcerative colitis; LUSC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg09021430 chr5:549028 NA -0.55 -7.17 -0.37 4.85e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg22963979 chr7:1858916 MAD1L1 -0.55 -8.39 -0.42 1.43e-15 Bipolar disorder and schizophrenia; LUSC cis rs6504663 0.558 rs2412325 chr17:48546232 G/C cg03611598 chr17:48586076 MYCBPAP 0.46 5.94 0.31 7.26e-9 Visceral fat; LUSC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg18904891 chr8:8559673 CLDN23 0.41 6.31 0.33 9.06e-10 Mood instability; LUSC cis rs2274459 0.841 rs3818526 chr6:33660973 T/C cg06253072 chr6:33679850 C6orf125 0.48 5.76 0.3 1.89e-8 Obesity (extreme); LUSC cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg18225595 chr11:63971243 STIP1 0.42 6.75 0.35 6.52e-11 Platelet count; LUSC cis rs3126085 0.825 rs868303 chr1:152178563 C/A cg03465714 chr1:152285911 FLG -0.41 -5.75 -0.3 2e-8 Atopic dermatitis; LUSC cis rs7577851 0.625 rs56250322 chr2:69546480 G/A cg10773587 chr2:69614142 GFPT1 0.59 6.3 0.33 9.29e-10 Parkinson's disease (age of onset); LUSC cis rs10435719 0.902 rs12681142 chr8:11802601 T/C cg21775007 chr8:11205619 TDH 0.46 6.61 0.34 1.55e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg23583168 chr7:148888333 NA -0.88 -16.45 -0.67 5.76e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs1908814 0.516 rs56102998 chr8:11796675 G/A cg27411982 chr8:10470053 RP1L1 0.4 6.18 0.32 1.91e-9 Neuroticism; LUSC cis rs9467711 0.606 rs9366653 chr6:26354247 G/A cg09904177 chr6:26538194 HMGN4 -0.7 -6.65 -0.34 1.17e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs11250098 0.503 rs13270870 chr8:10770782 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.34 -0.37 1.65e-12 Morning vs. evening chronotype; LUSC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg23630131 chr7:65973040 NA 0.21 5.81 0.3 1.43e-8 Aortic root size; LUSC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs73206853 0.686 rs73194039 chr12:111179153 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.67 0.34 1.08e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg04733989 chr22:42467013 NAGA 0.61 9.48 0.46 4.84e-19 Schizophrenia; LUSC cis rs981844 0.775 rs17371468 chr4:154759826 G/C cg14289246 chr4:154710475 SFRP2 0.5 6.67 0.34 1.09e-10 Response to statins (LDL cholesterol change); LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg11494091 chr17:61959527 GH2 0.64 13.66 0.6 4.71e-34 Prudent dietary pattern; LUSC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg23630131 chr7:65973040 NA 0.2 5.74 0.3 2.1e-8 Aortic root size; LUSC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg23719950 chr11:63933701 MACROD1 -0.35 -5.68 -0.3 2.98e-8 Platelet count; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg16132339 chr22:24313637 DDTL;DDT 0.38 6.11 0.32 2.7e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13385 0.773 rs10067578 chr5:139558496 G/T cg26211634 chr5:139558579 C5orf32 0.45 6.54 0.34 2.25e-10 Atrial fibrillation; LUSC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.09 -0.32 3.16e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 29.27 0.85 3.41e-94 Chronic sinus infection; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16987101 chr1:226297828 NA -0.55 -6.72 -0.35 7.81e-11 Bipolar disorder and schizophrenia; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg07424592 chr7:64974309 NA -0.4 -5.7 -0.3 2.7e-8 Calcium levels; LUSC cis rs6076065 0.748 rs6048784 chr20:23382652 A/T cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs3087591 0.960 rs2905869 chr17:29519016 C/A cg24425628 chr17:29625626 OMG;NF1 0.55 8.0 0.4 2.02e-14 Hip circumference; LUSC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg05861140 chr6:150128134 PCMT1 -0.4 -6.31 -0.33 8.8e-10 Lung cancer; LUSC cis rs926938 0.527 rs360672 chr1:115483836 C/T cg01522456 chr1:115632236 TSPAN2 -0.41 -6.41 -0.33 5.03e-10 Autism; LUSC cis rs11608355 0.506 rs11066471 chr12:109828039 T/C cg19025524 chr12:109796872 NA -0.5 -9.09 -0.45 9.2e-18 Neuroticism; LUSC cis rs7267979 0.903 rs6050481 chr20:25224580 C/T cg08601574 chr20:25228251 PYGB 0.49 7.55 0.38 4.23e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9811920 0.695 rs1287284 chr3:99516962 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -5.69 -0.3 2.85e-8 Axial length; LUSC cis rs9296095 0.607 rs9366824 chr6:33521577 C/T cg14003231 chr6:33640908 ITPR3 0.38 6.66 0.34 1.13e-10 Platelet count; LUSC cis rs2073300 0.609 rs6137919 chr20:23363163 T/C cg12062639 chr20:23401060 NAPB 0.92 8.03 0.4 1.65e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs11051970 0.877 rs2728671 chr12:32589715 T/A cg24626660 chr12:32551988 NA 0.33 5.66 0.3 3.2e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg21535247 chr6:8435926 SLC35B3 0.57 9.0 0.44 1.69e-17 Motion sickness; LUSC cis rs12760731 0.623 rs10913549 chr1:178383657 C/G cg00404053 chr1:178313656 RASAL2 0.48 5.75 0.3 2.04e-8 Obesity-related traits; LUSC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.48 -6.92 -0.35 2.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs77633900 0.772 rs8031672 chr15:76700553 T/C cg21673338 chr15:77095150 SCAPER 0.65 5.88 0.31 9.92e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2290416 0.892 rs3829012 chr8:144664656 C/T cg26536354 chr8:144654954 C8orf73 0.64 7.32 0.37 1.88e-12 Attention deficit hyperactivity disorder; LUSC cis rs4808199 0.895 rs2285628 chr19:19467996 T/A cg03709012 chr19:19516395 GATAD2A 1.02 12.32 0.56 5.32e-29 Nonalcoholic fatty liver disease; LUSC trans rs450533 0.541 rs433201 chr4:107851275 G/A cg19546012 chr19:752860 C19orf21 -0.29 -6.22 -0.32 1.52e-9 Cancer; LUSC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.6 -0.38 3.06e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11301069 chr17:8027502 HES7 -0.48 -6.27 -0.32 1.14e-9 Bipolar disorder and schizophrenia; LUSC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg06238570 chr21:40685208 BRWD1 0.48 7.45 0.38 8.14e-13 Cognitive function; LUSC cis rs11122272 0.735 rs2790891 chr1:231513190 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs473651 0.506 rs561264 chr2:239329979 G/T cg18131467 chr2:239335373 ASB1 0.75 11.26 0.52 3.87e-25 Multiple system atrophy; LUSC cis rs34779708 0.931 rs79749947 chr10:35277081 A/T cg03585969 chr10:35415529 CREM 0.65 9.34 0.45 1.45e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs698813 0.572 rs13424464 chr2:44482263 A/C cg00619915 chr2:44497795 NA -0.53 -7.35 -0.37 1.51e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg18230493 chr5:56204884 C5orf35 -0.78 -11.0 -0.52 3.09e-24 Initial pursuit acceleration; LUSC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg03929089 chr4:120376271 NA -0.49 -6.91 -0.35 2.47e-11 HDL cholesterol; LUSC trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg15704280 chr7:45808275 SEPT13 -0.82 -11.51 -0.53 4.93e-26 Coronary artery disease; LUSC cis rs76878669 0.561 rs4930179 chr11:66157432 C/T cg24851651 chr11:66362959 CCS -0.38 -6.08 -0.32 3.34e-9 Educational attainment (years of education); LUSC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg03289416 chr15:75166202 SCAMP2 0.45 6.81 0.35 4.65e-11 Breast cancer; LUSC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg25767906 chr1:53392781 SCP2 0.39 6.66 0.34 1.12e-10 Monocyte count; LUSC cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg03146154 chr1:46216737 IPP -0.55 -8.29 -0.41 2.87e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs4909189 1.000 rs62493649 chr7:158135556 C/G cg06219351 chr7:158114137 PTPRN2 -0.53 -8.41 -0.42 1.24e-15 Response to amphetamines; LUSC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg09877947 chr5:131593287 PDLIM4 -0.44 -6.62 -0.34 1.44e-10 Breast cancer; LUSC cis rs131777 0.547 rs131753 chr22:51022862 A/G cg25575065 chr22:51066394 ARSA -0.42 -5.93 -0.31 7.46e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7582180 0.663 rs930374 chr2:100962700 A/G cg12002119 chr2:101014098 CHST10 0.34 5.68 0.3 2.92e-8 Intelligence (multi-trait analysis); LUSC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg15557168 chr22:42548783 NA 0.38 6.37 0.33 6.22e-10 Cognitive function; LUSC trans rs9467711 0.606 rs28360517 chr6:26602453 A/G cg06606381 chr12:133084897 FBRSL1 -0.68 -6.74 -0.35 7.03e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs35110281 0.627 rs1436291 chr21:44965485 T/C cg04455712 chr21:45112962 RRP1B 0.44 8.43 0.42 1.05e-15 Mean corpuscular volume; LUSC cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg07828340 chr4:882639 GAK -1.06 -11.64 -0.54 1.65e-26 Intelligence (multi-trait analysis); LUSC cis rs2455601 0.744 rs11042133 chr11:8966511 A/C cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -8.15 -0.41 7.5e-15 Schizophrenia; LUSC cis rs1941023 0.567 rs955019 chr11:60174250 C/T cg08716584 chr11:60157161 MS4A7 -0.56 -10.5 -0.5 1.75e-22 Congenital heart disease (maternal effect); LUSC cis rs7223966 1.000 rs16947014 chr17:61719032 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.78 0.35 5.34e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2658782 0.724 rs2605626 chr11:93253903 A/G cg15737290 chr11:93063684 CCDC67 0.58 6.91 0.35 2.42e-11 Pulmonary function decline; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.63 0.65 9.98e-42 Platelet count; LUSC cis rs17253792 0.822 rs12100949 chr14:56040787 T/C cg01858014 chr14:56050164 KTN1 -0.76 -6.24 -0.32 1.32e-9 Putamen volume; LUSC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg23601095 chr6:26197514 HIST1H3D 0.72 7.32 0.37 1.86e-12 Gout;Renal underexcretion gout; LUSC cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg07274523 chr3:49395745 GPX1 0.67 10.37 0.49 5.13e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg02569458 chr12:86230093 RASSF9 -0.57 -9.69 -0.47 1.03e-19 Major depressive disorder; LUSC cis rs611744 0.550 rs57045491 chr8:109279120 A/C cg21045802 chr8:109455806 TTC35 0.42 6.58 0.34 1.79e-10 Dupuytren's disease; LUSC cis rs1371867 0.846 rs2453624 chr8:101230523 A/G cg06636551 chr8:101224915 SPAG1 0.47 8.76 0.43 9.83e-17 Atrioventricular conduction; LUSC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.76 -0.43 9.95e-17 Lung cancer; LUSC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg06740227 chr12:86229804 RASSF9 0.39 6.09 0.32 3.05e-9 Major depressive disorder; LUSC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg14440974 chr22:39074834 NA -0.39 -6.42 -0.33 4.58e-10 Menopause (age at onset); LUSC cis rs73195822 0.614 rs55946973 chr12:111214936 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.06 0.36 9.82e-12 Itch intensity from mosquito bite; LUSC cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.84 -0.3 1.27e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg03929089 chr4:120376271 NA 0.82 11.14 0.52 9.93e-25 Coronary artery disease; LUSC cis rs7582180 0.845 rs11683088 chr2:100920667 C/T cg12002119 chr2:101014098 CHST10 0.34 5.74 0.3 2.11e-8 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg21770322 chr7:97807741 LMTK2 0.42 7.26 0.37 2.7e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7917772 0.582 rs12779854 chr10:104358474 G/A cg22532475 chr10:104410764 TRIM8 0.26 6.14 0.32 2.32e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10392 0.543 rs58414555 chr20:37554152 A/C cg27552599 chr20:37590471 DHX35 0.45 7.26 0.37 2.74e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs7246657 0.551 rs28462002 chr19:37634462 A/G cg23950597 chr19:37808831 NA -0.57 -6.08 -0.32 3.34e-9 Coronary artery calcification; LUSC cis rs3782089 1.000 rs11600543 chr11:65298939 G/A cg08676812 chr11:65308423 LTBP3 1.06 6.8 0.35 4.71e-11 Height; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.06e-17 Prudent dietary pattern; LUSC cis rs17604090 0.775 rs10225523 chr7:29689735 C/A cg19413766 chr7:29689036 LOC646762 -0.56 -7.12 -0.36 6.67e-12 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs1153858 1.000 rs4775895 chr15:45617957 T/A cg14582100 chr15:45693742 SPATA5L1 0.59 10.52 0.5 1.53e-22 Homoarginine levels; LUSC trans rs61931739 0.929 rs10844730 chr12:34026721 C/G cg13010199 chr12:38710504 ALG10B -0.45 -7.09 -0.36 8.27e-12 Morning vs. evening chronotype; LUSC cis rs6430585 0.759 rs12467770 chr2:136536095 G/A cg07169764 chr2:136633963 MCM6 1.18 17.48 0.69 4.99e-49 Corneal structure; LUSC cis rs17152411 1.000 rs7092008 chr10:126638226 G/A cg07906193 chr10:126599966 NA 0.42 5.81 0.3 1.48e-8 Height; LUSC cis rs7267979 0.816 rs422148 chr20:25512604 G/C cg14121845 chr20:25566513 NINL 0.31 5.7 0.3 2.63e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 14.53 0.62 2.01e-37 Platelet count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15583014 chr1:65468659 NA 0.78 6.35 0.33 7.1e-10 Cognitive performance; LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg26314531 chr2:26401878 FAM59B 0.74 10.06 0.48 5.92e-21 Gut microbiome composition (summer); LUSC cis rs936229 0.861 rs7180484 chr15:75115416 G/T cg10253484 chr15:75165896 SCAMP2 0.5 6.7 0.34 8.73e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs11650494 0.908 rs77247327 chr17:47411493 T/C cg08112188 chr17:47440006 ZNF652 1.22 10.05 0.48 6.07e-21 Prostate cancer; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg11645453 chr3:52864694 ITIH4 0.36 8.63 0.43 2.5e-16 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05610379 chr10:123734658 NSMCE4A -0.53 -6.42 -0.33 4.8e-10 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06879705 chr2:99771525 LIPT1;TSGA10 0.74 6.26 0.32 1.21e-9 Cognitive performance; LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6066835 1.000 rs6066829 chr20:47351630 G/T cg18078177 chr20:47281410 PREX1 -0.69 -6.72 -0.34 7.99e-11 Multiple myeloma; LUSC cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg15605315 chr1:45957053 TESK2 -0.44 -6.77 -0.35 5.93e-11 High light scatter reticulocyte count; LUSC cis rs7824557 0.585 rs2572385 chr8:11208903 G/A cg21775007 chr8:11205619 TDH 0.8 12.66 0.57 2.73e-30 Retinal vascular caliber; LUSC cis rs10791323 0.511 rs4937837 chr11:133731134 T/C cg15485101 chr11:133734466 NA 0.4 7.3 0.37 2.14e-12 Childhood ear infection; LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg23758822 chr17:41437982 NA 1.03 19.45 0.73 7.3e-57 Menopause (age at onset); LUSC cis rs4494114 0.967 rs9438976 chr1:39353386 C/T cg25970120 chr1:39325951 RRAGC -0.4 -6.19 -0.32 1.8e-9 Blood protein levels; LUSC cis rs12545109 0.800 rs2610052 chr8:57411316 C/A cg09654669 chr8:57350985 NA -0.57 -7.81 -0.39 7.71e-14 Obesity-related traits; LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.54 6.61 0.34 1.53e-10 Renal function-related traits (BUN); LUSC cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.93 -0.31 7.4e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg20476274 chr7:133979776 SLC35B4 0.78 13.61 0.6 7.29e-34 Mean platelet volume; LUSC cis rs9303401 0.703 rs9909925 chr17:57210069 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.49 -7.32 -0.37 1.87e-12 Cognitive test performance; LUSC cis rs2235649 0.833 rs9939694 chr16:1852760 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.13 -0.32 2.55e-9 Blood metabolite levels; LUSC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg26818010 chr10:134567672 INPP5A -0.87 -11.25 -0.52 4.2e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7834588 0.523 rs9298067 chr8:63806223 G/A cg20602954 chr8:63776762 NKAIN3 0.42 6.15 0.32 2.24e-9 Response to Vitamin E supplementation; LUSC cis rs10744422 0.925 rs897391 chr12:123326374 G/A cg25930673 chr12:123319894 HIP1R -0.63 -6.23 -0.32 1.41e-9 Schizophrenia; LUSC trans rs877282 0.755 rs2486579 chr10:785647 G/A cg22713356 chr15:30763199 NA 0.89 12.81 0.57 8e-31 Uric acid levels; LUSC cis rs460214 0.528 rs6517474 chr21:40023133 G/A cg21578987 chr21:40029669 ERG 0.4 6.2 0.32 1.67e-9 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg09177884 chr7:1199841 ZFAND2A -0.58 -7.91 -0.4 3.75e-14 Longevity;Endometriosis; LUSC cis rs2115630 0.791 rs2008262 chr15:85305270 C/T cg17173187 chr15:85201210 NMB -0.3 -6.14 -0.32 2.33e-9 P wave terminal force; LUSC trans rs1325195 0.879 rs9727861 chr1:179092612 A/C cg11624085 chr17:8464688 MYH10 -0.43 -7.2 -0.37 4.05e-12 IgE grass sensitization; LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg05863683 chr7:1912471 MAD1L1 0.3 5.7 0.3 2.67e-8 Bipolar disorder and schizophrenia; LUSC cis rs6120849 0.754 rs6120828 chr20:33674460 A/G cg24642439 chr20:33292090 TP53INP2 0.59 6.62 0.34 1.4e-10 Protein C levels; LUSC cis rs7608623 0.773 rs11125168 chr2:23922383 C/T cg08917208 chr2:24149416 ATAD2B -0.43 -5.88 -0.31 9.75e-9 Obesity-related traits; LUSC cis rs2262909 0.962 rs425781 chr19:22229306 A/G cg11619707 chr19:22235551 ZNF257 -0.38 -5.7 -0.3 2.7e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 1.000 rs6050609 chr20:25411751 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg13256891 chr4:100009986 ADH5 0.46 6.39 0.33 5.61e-10 Alcohol dependence; LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.05e-10 Life satisfaction; LUSC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg16228356 chr17:43848958 NA 0.25 5.81 0.3 1.48e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs5758511 0.773 rs9680671 chr22:42351477 T/C cg00645731 chr22:42541494 CYP2D7P1 0.43 7.08 0.36 8.49e-12 Birth weight; LUSC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16569376 chr16:15982511 C16orf63 0.79 6.14 0.32 2.33e-9 Cognitive performance; LUSC cis rs7131987 0.903 rs10843371 chr12:29414232 G/A cg09582351 chr12:29534625 ERGIC2 -0.32 -6.62 -0.34 1.39e-10 QT interval; LUSC cis rs8060686 0.641 rs76053508 chr16:68243054 A/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.94 -0.31 7.01e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs929354 0.772 rs6459741 chr7:157014553 G/T cg17757837 chr7:157058334 UBE3C 0.82 13.3 0.59 1.14e-32 Body mass index; LUSC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4892230 1 rs4892230 chr18:72155572 G/A cg26446133 chr18:72167187 CNDP2 -0.6 -8.08 -0.4 1.19e-14 Mononucleosis; LUSC cis rs9399401 0.667 rs12213892 chr6:142702234 A/G cg03128060 chr6:142623767 GPR126 0.61 9.98 0.48 1.1e-20 Chronic obstructive pulmonary disease; LUSC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19905802 chr11:62554200 TMEM179B;TAF6L -0.5 -6.47 -0.33 3.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs2109514 0.840 rs6953982 chr7:116129290 C/T cg12739419 chr7:116140593 CAV2 -0.27 -5.77 -0.3 1.77e-8 Prevalent atrial fibrillation; LUSC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg04362960 chr10:104952993 NT5C2 -0.53 -6.55 -0.34 2.17e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17270561 0.636 rs1165216 chr6:25797971 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 6.3 0.33 9.61e-10 Iron status biomarkers; LUSC cis rs9937943 0.512 rs13335886 chr16:74577161 C/G cg01733217 chr16:74700730 RFWD3 -0.63 -8.15 -0.41 7.4e-15 Neutrophil percentage of white cells; LUSC trans rs8072100 0.840 rs9893901 chr17:45506682 T/G cg03886242 chr7:26192032 NFE2L3 -0.39 -6.4 -0.33 5.26e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12136530 0.774 rs4911996 chr1:19765205 C/G cg01832549 chr1:19774989 CAPZB 0.31 5.68 0.3 2.87e-8 Lead levels in blood; LUSC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg00033643 chr7:134001901 SLC35B4 0.47 7.27 0.37 2.58e-12 Mean platelet volume; LUSC cis rs240764 0.853 rs12374612 chr6:100955752 C/T cg09795085 chr6:101329169 ASCC3 -0.41 -5.99 -0.31 5.53e-9 Neuroticism; LUSC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg03526776 chr6:41159608 TREML2 0.5 10.46 0.5 2.36e-22 Alzheimer's disease (late onset); LUSC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg14552801 chr7:65878734 NA 0.36 5.71 0.3 2.48e-8 Aortic root size; LUSC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg10130564 chr11:117069849 TAGLN -0.38 -6.53 -0.34 2.43e-10 Blood protein levels; LUSC cis rs7236492 0.577 rs7236190 chr18:77198217 T/C cg15644404 chr18:77186268 NFATC1 -0.5 -6.91 -0.35 2.41e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17154702 0.506 rs74525088 chr8:8628413 A/T cg01851573 chr8:8652454 MFHAS1 0.59 6.99 0.36 1.45e-11 Neurocognitive impairment in HIV-1 infection (continuous); LUSC cis rs9527 0.590 rs10883820 chr10:104764661 A/C cg23093090 chr10:104574429 C10orf26 0.35 6.46 0.33 3.61e-10 Arsenic metabolism; LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg08280861 chr8:58055591 NA 0.53 6.86 0.35 3.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs7215564 0.908 rs2316060 chr17:78663728 T/C cg09596252 chr17:78655493 RPTOR 0.53 5.85 0.31 1.15e-8 Myopia (pathological); LUSC cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg11266682 chr4:10021025 SLC2A9 -0.43 -7.31 -0.37 2.01e-12 Bone mineral density; LUSC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg07936489 chr17:37558343 FBXL20 0.68 9.9 0.48 1.94e-20 Glomerular filtration rate (creatinine); LUSC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.74e-10 Total body bone mineral density; LUSC cis rs4561483 0.801 rs8061189 chr16:11951749 C/G cg08843971 chr16:11963173 GSPT1 0.49 7.3 0.37 2.17e-12 Testicular germ cell tumor; LUSC cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg09469691 chr10:81107165 PPIF 0.65 9.62 0.47 1.66e-19 Height; LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs3540 0.554 rs12900987 chr15:91071776 T/C cg10434728 chr15:90938212 IQGAP1 -0.44 -8.96 -0.44 2.33e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs853679 0.607 rs201002 chr6:27808192 A/G cg01620082 chr3:125678407 NA -0.65 -7.13 -0.36 6.42e-12 Depression; LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg25036284 chr2:26402008 FAM59B -0.77 -11.38 -0.53 1.46e-25 Gut microbiome composition (summer); LUSC trans rs1927790 0.667 rs7981845 chr13:96942533 C/T cg03198741 chr6:1003969 LOC285768 -0.39 -5.95 -0.31 6.79e-9 Body mass index; LUSC cis rs6459804 1.000 rs58278053 chr7:157512934 A/T cg05731713 chr7:157510257 PTPRN2 0.47 8.94 0.44 2.68e-17 Bipolar disorder and schizophrenia; LUSC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.04 0.31 4.22e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6691722 0.506 rs12030365 chr1:24739220 T/A cg02336364 chr1:24764700 NIPAL3 0.34 6.16 0.32 2.1e-9 Response to interferon beta in multiple sclerosis; LUSC cis rs1048238 0.506 rs7547314 chr1:16186722 G/A cg21385522 chr1:16154831 NA 0.56 8.82 0.43 6.67e-17 Systolic blood pressure; LUSC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg08109568 chr15:31115862 NA 0.56 6.97 0.36 1.69e-11 Huntington's disease progression; LUSC cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg06028605 chr16:24865363 SLC5A11 -0.52 -9.14 -0.45 6.32e-18 Intelligence (multi-trait analysis); LUSC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg11214544 chr1:2391121 NA -0.33 -5.68 -0.3 2.9e-8 Schizophrenia; LUSC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg15649852 chr7:65879115 NA -0.42 -5.72 -0.3 2.41e-8 Aortic root size; LUSC cis rs7267979 0.565 rs6107060 chr20:25592476 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.71 12.84 0.58 5.79e-31 Liver enzyme levels (alkaline phosphatase); LUSC trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg27661571 chr11:113659931 NA -0.67 -7.74 -0.39 1.22e-13 Hip circumference adjusted for BMI; LUSC cis rs2019216 0.500 rs6565385 chr17:21897646 C/A cg22648282 chr17:21454238 C17orf51 -0.52 -7.84 -0.39 6.27e-14 Pelvic organ prolapse; LUSC cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.16 0.55 2.03e-28 Motion sickness; LUSC cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -14.28 -0.62 1.95e-36 Chronic sinus infection; LUSC cis rs10979 0.965 rs9496679 chr6:143896741 G/T cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs2624839 0.704 rs1046956 chr3:50222926 T/A cg14019146 chr3:50243930 SLC38A3 0.52 12.7 0.57 1.97e-30 Intelligence (multi-trait analysis); LUSC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg19717773 chr7:2847554 GNA12 -0.38 -6.02 -0.31 4.59e-9 Height; LUSC cis rs8017423 0.967 rs57793584 chr14:90714833 G/A cg04374321 chr14:90722782 PSMC1 0.77 12.46 0.56 1.64e-29 Mortality in heart failure; LUSC cis rs7917772 0.560 rs10786697 chr10:104378563 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.7 11.25 0.52 4.24e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg17971929 chr21:40555470 PSMG1 -0.51 -7.57 -0.38 3.62e-13 Menarche (age at onset); LUSC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg00750074 chr16:89608354 SPG7 -0.47 -8.21 -0.41 4.95e-15 Multiple myeloma (IgH translocation); LUSC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.94 0.44 2.77e-17 Height; LUSC cis rs3106136 0.967 rs2632399 chr4:95153741 G/T cg11021082 chr4:95130006 SMARCAD1 -0.34 -5.93 -0.31 7.72e-9 Capecitabine sensitivity; LUSC cis rs6964587 1.000 rs10488512 chr7:91753579 C/T cg22117172 chr7:91764530 CYP51A1 0.34 5.98 0.31 5.68e-9 Breast cancer; LUSC cis rs12908161 0.959 rs12906348 chr15:85329421 A/C cg12863693 chr15:85201151 NMB 0.4 8.02 0.4 1.79e-14 Schizophrenia; LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg12564285 chr5:131593104 PDLIM4 -0.47 -8.04 -0.4 1.6e-14 Blood metabolite levels; LUSC cis rs4919687 0.550 rs11191371 chr10:104459897 G/C cg04362960 chr10:104952993 NT5C2 0.47 6.82 0.35 4.17e-11 Colorectal cancer; LUSC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg05585544 chr11:47624801 NA -0.41 -7.32 -0.37 1.86e-12 Subjective well-being; LUSC cis rs9644630 0.658 rs4427190 chr8:19321385 C/T cg01280390 chr8:19363452 CSGALNACT1 -0.31 -5.79 -0.3 1.6e-8 Oropharynx cancer; LUSC cis rs7843479 1.000 rs2054711 chr8:21818060 A/G cg17168535 chr8:21777572 XPO7 0.67 10.3 0.49 8.44e-22 Mean corpuscular volume; LUSC cis rs61990749 0.544 rs11628888 chr14:78161506 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.6 -6.39 -0.33 5.52e-10 Fibroblast growth factor basic levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07085396 chr18:12325516 TUBB6 0.46 6.43 0.33 4.44e-10 Bipolar disorder and schizophrenia; LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.29 0.33 9.79e-10 Bipolar disorder; LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg07167872 chr1:205819463 PM20D1 0.52 7.9 0.4 3.94e-14 Prostate-specific antigen levels; LUSC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg11764359 chr7:65958608 NA -0.54 -7.11 -0.36 7.23e-12 Aortic root size; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.55 -8.0 -0.4 2.1e-14 Renal function-related traits (BUN); LUSC cis rs7647973 0.922 rs7620024 chr3:49451691 G/A cg07636037 chr3:49044803 WDR6 -0.69 -8.92 -0.44 3.02e-17 Menarche (age at onset); LUSC cis rs11048434 0.761 rs10842662 chr12:9139344 G/A cg23795048 chr12:9217529 LOC144571 0.34 5.84 0.3 1.27e-8 Sjögren's syndrome; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16265552 chr3:113667068 ZDHHC23 0.43 6.11 0.32 2.84e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs34779708 0.658 rs4934715 chr10:35364992 G/T cg03585969 chr10:35415529 CREM 0.63 9.39 0.46 9.85e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11971779 0.715 rs10265 chr7:139026152 T/G cg23387468 chr7:139079360 LUC7L2 0.4 6.05 0.31 3.97e-9 Diisocyanate-induced asthma; LUSC cis rs62027291 0.948 rs62007172 chr15:77306741 G/A cg26408565 chr15:76604113 ETFA 0.52 6.21 0.32 1.55e-9 Plateletcrit; LUSC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.509 rs6115218 chr20:25566485 A/G cg03522245 chr20:25566470 NINL 0.53 7.66 0.39 2.09e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg02822958 chr2:46747628 ATP6V1E2 0.42 6.26 0.32 1.19e-9 Height; LUSC trans rs459571 0.959 rs2073818 chr9:136918662 C/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.43 -6.12 -0.32 2.61e-9 Platelet distribution width; LUSC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -6.77 -0.35 5.9e-11 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg18252515 chr7:66147081 NA 1.18 12.44 0.56 1.89e-29 Diabetic kidney disease; LUSC cis rs17685 0.712 rs10952842 chr7:75780413 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.54 -8.23 -0.41 4.13e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7119 0.635 rs59745219 chr15:77884130 A/G cg27398640 chr15:77910606 LINGO1 0.36 8.57 0.42 3.93e-16 Type 2 diabetes; LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.59 0.6 8.31e-34 Platelet count; LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.91 -0.35 2.5e-11 Bipolar disorder and schizophrenia; LUSC cis rs17095355 0.786 rs58096078 chr10:111734286 C/G cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.31 -0.37 2.01e-12 Biliary atresia; LUSC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg16615211 chr3:44902933 MIR564;TMEM42 0.38 6.56 0.34 2.1e-10 Depressive symptoms; LUSC cis rs858239 0.730 rs858289 chr7:23248158 C/T cg05407003 chr7:23246146 NA -0.38 -5.74 -0.3 2.1e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7474896 0.515 rs675628 chr10:38305331 C/G cg25427524 chr10:38739819 LOC399744 0.48 6.21 0.32 1.61e-9 Obesity (extreme); LUSC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg20476274 chr7:133979776 SLC35B4 0.88 17.04 0.68 2.81e-47 Mean platelet volume; LUSC trans rs10497394 0.959 rs962782 chr2:174302988 G/T cg03531853 chr9:86535572 KIF27 -0.58 -6.03 -0.31 4.43e-9 Otitis media (chronic/recurrent); LUSC cis rs983392 0.836 rs7935829 chr11:59942815 A/G cg24026212 chr11:59952134 MS4A6A -0.37 -6.26 -0.32 1.2e-9 Alzheimer's disease (late onset); LUSC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg06713675 chr4:122721982 EXOSC9 -0.69 -12.02 -0.55 6.45e-28 Type 2 diabetes; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg10150615 chr22:24372951 LOC391322 -0.35 -5.93 -0.31 7.37e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.18e-11 Developmental language disorder (linguistic errors); LUSC cis rs1152591 0.543 rs1152592 chr14:64676098 A/G cg21174375 chr14:64681225 SYNE2 0.33 6.01 0.31 4.85e-9 Atrial fibrillation; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg19318889 chr4:1322082 MAEA 0.45 7.41 0.38 1.04e-12 Obesity-related traits; LUSC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg13395646 chr4:1353034 KIAA1530 -0.6 -9.62 -0.47 1.71e-19 Longevity; LUSC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC trans rs747782 0.585 rs1604655 chr11:48274778 G/A cg03929089 chr4:120376271 NA 0.66 6.25 0.32 1.23e-9 Intraocular pressure; LUSC cis rs7216064 1.000 rs4790908 chr17:65852907 T/G cg12091567 chr17:66097778 LOC651250 -0.72 -9.39 -0.46 9.94e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs5167 0.781 rs2075619 chr19:45495682 A/G cg13119609 chr19:45449297 APOC2 0.33 5.74 0.3 2.09e-8 Blood protein levels; LUSC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg06221963 chr1:154839813 KCNN3 0.59 13.07 0.58 8e-32 Prostate cancer; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.57 9.55 0.46 2.87e-19 Lymphocyte counts; LUSC cis rs12791968 0.527 rs12279115 chr11:45014587 G/C cg11846598 chr11:44996168 LOC221122 -0.53 -6.15 -0.32 2.21e-9 Inhibitory control; LUSC trans rs6982636 0.765 rs6982502 chr8:126479362 C/T cg13325919 chr3:181432053 SOX2;SOX2OT -0.32 -6.02 -0.31 4.51e-9 Lipid metabolism phenotypes; LUSC cis rs10740039 0.516 rs7477771 chr10:62355728 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.89 -0.35 2.83e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2239547 0.603 rs4687698 chr3:53097108 C/T cg18404041 chr3:52824283 ITIH1 -0.55 -9.41 -0.46 8.12e-19 Schizophrenia; LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg07395648 chr5:131743802 NA 0.42 6.01 0.31 4.97e-9 Blood metabolite levels; LUSC cis rs6964587 1.000 rs415 chr7:91580490 A/G cg22117172 chr7:91764530 CYP51A1 -0.32 -5.76 -0.3 1.89e-8 Breast cancer; LUSC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg16680214 chr1:154839983 KCNN3 -0.53 -10.03 -0.48 7.38e-21 Prostate cancer; LUSC cis rs9649213 0.614 rs9641236 chr7:97998124 T/A cg09267113 chr7:98030324 BAIAP2L1 -0.73 -10.15 -0.49 2.77e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs116988415 0.584 rs1875054 chr14:65255066 G/A cg00114569 chr14:65239327 SPTB 0.67 7.08 0.36 8.72e-12 Daytime sleep phenotypes; LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03576123 chr11:487126 PTDSS2 -0.99 -10.56 -0.5 1.11e-22 Body mass index; LUSC cis rs17401966 0.540 rs7546368 chr1:10418826 G/A cg19773385 chr1:10388646 KIF1B -0.36 -6.32 -0.33 8.28e-10 Hepatocellular carcinoma; LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg10729496 chr3:10149963 C3orf24 0.58 7.71 0.39 1.48e-13 Alzheimer's disease; LUSC cis rs2762353 0.935 rs1165196 chr6:25813150 A/G cg12310025 chr6:25882481 NA 0.44 7.66 0.39 2.05e-13 Blood metabolite levels; LUSC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs950169 0.544 rs2036949 chr15:85163605 T/C cg12863693 chr15:85201151 NMB 0.4 8.33 0.41 2.16e-15 Schizophrenia; LUSC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg06740227 chr12:86229804 RASSF9 0.43 6.83 0.35 4.04e-11 Major depressive disorder; LUSC cis rs11166629 1.000 rs4909332 chr8:135646340 T/C cg27224718 chr8:135614730 ZFAT 0.65 10.68 0.5 4.28e-23 Smoking quantity; LUSC cis rs1044826 1.000 rs3821545 chr3:139182971 C/G cg00490450 chr3:139108681 COPB2 0.5 6.42 0.33 4.79e-10 Obesity-related traits; LUSC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7246967 0.673 rs8103875 chr19:22866862 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg08270630 chr22:50330655 NA 0.4 5.93 0.31 7.52e-9 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06711307 chr19:10362455 MRPL4 -0.43 -6.49 -0.33 3.09e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg26304593 chr6:42947056 PEX6 -0.49 -7.36 -0.37 1.46e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4243830 0.850 rs7552196 chr1:6590502 G/A cg05709478 chr1:6581295 PLEKHG5 -0.55 -6.6 -0.34 1.62e-10 Body mass index; LUSC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg17633681 chr16:88106987 BANP 0.53 10.16 0.49 2.64e-21 Menopause (age at onset); LUSC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg05025164 chr4:1340916 KIAA1530 0.55 8.77 0.43 9.47e-17 Longevity; LUSC cis rs1322639 0.806 rs1322640 chr6:169586887 T/C cg03254818 chr6:169586852 NA -0.45 -6.31 -0.33 8.67e-10 Pulse pressure; LUSC trans rs1997103 1.000 rs6949244 chr7:55411301 C/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg12463550 chr7:65579703 CRCP -0.5 -7.39 -0.38 1.16e-12 Aortic root size; LUSC cis rs2078087 0.522 rs75394497 chr1:183215798 C/A cg13843938 chr1:183241246 NMNAT2 0.44 6.64 0.34 1.24e-10 Obesity-related traits; LUSC cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg06552810 chr11:31128660 NA -0.41 -7.23 -0.37 3.34e-12 Red blood cell count; LUSC cis rs9549260 0.755 rs4429172 chr13:41189143 C/A cg21288729 chr13:41239152 FOXO1 0.59 8.95 0.44 2.45e-17 Red blood cell count; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg14004847 chr7:1930337 MAD1L1 -0.57 -8.85 -0.44 5.37e-17 Bipolar disorder and schizophrenia; LUSC cis rs858239 0.601 rs4140959 chr7:23170776 C/T cg23682824 chr7:23144976 KLHL7 0.4 5.79 0.3 1.65e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.27 5.84 0.3 1.27e-8 Electroencephalogram traits; LUSC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg15649852 chr7:65879115 NA -0.41 -5.76 -0.3 1.96e-8 Aortic root size; LUSC cis rs8170 0.603 rs7249329 chr19:17423373 G/T cg04749549 chr19:17459798 NA -0.32 -5.84 -0.3 1.26e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC cis rs933688 0.526 rs9293565 chr5:90609736 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.55 5.7 0.3 2.68e-8 Smoking behavior; LUSC cis rs4363385 0.530 rs10888529 chr1:153050654 G/T cg25856811 chr1:152973957 SPRR3 -0.37 -6.14 -0.32 2.39e-9 Inflammatory skin disease; LUSC cis rs7804356 1.000 rs3801825 chr7:26856959 T/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg19717773 chr7:2847554 GNA12 -0.4 -6.25 -0.32 1.27e-9 Height; LUSC cis rs28374715 0.510 rs8034073 chr15:41545613 A/C cg18705301 chr15:41695430 NDUFAF1 -0.66 -11.35 -0.53 1.85e-25 Ulcerative colitis; LUSC cis rs7432375 0.610 rs28458819 chr3:136522314 A/G cg15507776 chr3:136538369 TMEM22 0.44 7.32 0.37 1.86e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg17294928 chr15:75287854 SCAMP5 -0.93 -13.47 -0.59 2.47e-33 Blood trace element (Zn levels); LUSC cis rs7927592 0.871 rs12941 chr11:68382193 C/T cg16797656 chr11:68205561 LRP5 0.38 6.19 0.32 1.77e-9 Total body bone mineral density; LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg15790184 chr11:494944 RNH1 0.54 5.81 0.3 1.46e-8 Body mass index; LUSC cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg03146154 chr1:46216737 IPP 0.56 8.42 0.42 1.1e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg07701084 chr6:150067640 NUP43 0.58 9.09 0.45 9.32e-18 Lung cancer; LUSC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg13393036 chr8:95962371 TP53INP1 0.44 8.6 0.43 3.05e-16 Type 2 diabetes; LUSC cis rs6456156 0.586 rs12213683 chr6:167460718 G/A cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg16405210 chr4:1374714 KIAA1530 -0.55 -8.29 -0.41 2.71e-15 Obesity-related traits; LUSC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg07701084 chr6:150067640 NUP43 0.51 7.27 0.37 2.65e-12 Lung cancer; LUSC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs7107174 1.000 rs72931639 chr11:78036703 C/T cg02023728 chr11:77925099 USP35 0.46 6.68 0.34 9.77e-11 Testicular germ cell tumor; LUSC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg11752832 chr7:134001865 SLC35B4 -0.6 -9.63 -0.47 1.61e-19 Mean platelet volume; LUSC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg25258033 chr6:167368657 RNASET2 0.39 6.28 0.32 1.07e-9 Crohn's disease; LUSC cis rs6834538 0.597 rs4834291 chr4:113482718 C/T cg05166686 chr4:113558556 LARP7;C4orf21 0.38 6.2 0.32 1.62e-9 Free thyroxine concentration; LUSC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg12826209 chr6:26865740 GUSBL1 0.78 9.84 0.47 3.21e-20 Intelligence (multi-trait analysis); LUSC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC trans rs2243480 1.000 rs34577383 chr7:65385726 C/T cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs11122272 0.766 rs1435166 chr1:231502310 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.35 -0.49 5.81e-22 Hemoglobin concentration; LUSC cis rs912057 1.000 rs912056 chr6:6736197 A/T cg06612196 chr6:6737390 NA 0.54 10.06 0.48 5.67e-21 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs8044995 0.563 rs61746794 chr16:68387457 C/T cg09835421 chr16:68378352 PRMT7 -0.81 -8.86 -0.44 4.73e-17 Schizophrenia; LUSC cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg13256891 chr4:100009986 ADH5 0.49 7.3 0.37 2.17e-12 Alcohol dependence; LUSC cis rs9549367 0.713 rs2480949 chr13:113853149 T/C cg00898013 chr13:113819073 PROZ 0.54 8.04 0.4 1.59e-14 Platelet distribution width; LUSC cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg06784218 chr1:46089804 CCDC17 -0.47 -9.0 -0.44 1.72e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg15423357 chr2:25149977 NA 0.4 7.76 0.39 1.04e-13 Body mass index in non-asthmatics; LUSC cis rs8014204 0.935 rs4903267 chr14:75360419 G/T cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.44 -0.53 8.86e-26 Caffeine consumption; LUSC cis rs992157 0.965 rs62182826 chr2:219148723 C/A cg20019365 chr2:219134978 PNKD;AAMP 0.53 8.33 0.41 2.19e-15 Colorectal cancer; LUSC cis rs2742234 0.554 rs1254963 chr10:43696086 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 7.0 0.36 1.41e-11 Hirschsprung disease; LUSC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg13319975 chr6:146136371 FBXO30 0.46 6.91 0.35 2.46e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6496044 0.568 rs1982742 chr15:86068750 A/G cg13263323 chr15:86062960 AKAP13 -0.37 -6.04 -0.31 4.14e-9 Interstitial lung disease; LUSC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg22166914 chr1:53195759 ZYG11B 0.68 11.49 0.53 5.62e-26 Monocyte count; LUSC cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg23711669 chr6:146136114 FBXO30 -0.83 -15.28 -0.64 2.37e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg05347473 chr6:146136440 FBXO30 0.49 8.3 0.41 2.7e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7829975 0.606 rs11776838 chr8:8794801 C/T cg15556689 chr8:8085844 FLJ10661 -0.58 -9.86 -0.47 2.75e-20 Mood instability; LUSC trans rs11992162 0.636 rs4841644 chr8:11798433 A/C cg06636001 chr8:8085503 FLJ10661 0.46 6.4 0.33 5.3e-10 Monocyte count; LUSC trans rs853679 0.882 rs4713140 chr6:28097193 C/T cg06606381 chr12:133084897 FBRSL1 -0.64 -7.13 -0.36 6.15e-12 Depression; LUSC cis rs7223966 0.921 rs34699959 chr17:61960720 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.16 0.36 5.3e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs3924048 0.559 rs6541038 chr1:12626210 G/T cg00291366 chr1:12616550 NA 0.33 7.58 0.38 3.36e-13 Optic cup area; LUSC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg04369109 chr6:150039330 LATS1 -0.45 -5.99 -0.31 5.35e-9 Lung cancer; LUSC cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg08999081 chr20:33150536 PIGU 0.55 11.0 0.52 3.3e-24 Coronary artery disease; LUSC cis rs9297145 0.761 rs12534399 chr7:98746401 A/G cg05967295 chr7:98741636 SMURF1 0.99 14.84 0.63 1.34e-38 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18374471 chr6:131384607 EPB41L2 -0.46 -7.08 -0.36 8.76e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.22 0.32 1.5e-9 Schizophrenia; LUSC trans rs853679 0.556 rs34706883 chr6:27805255 A/C cg06606381 chr12:133084897 FBRSL1 -1.0 -8.84 -0.44 5.76e-17 Depression; LUSC cis rs12200782 1.000 rs6456742 chr6:26617075 T/C cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs6076065 0.723 rs7269627 chr20:23362727 A/T cg11657817 chr20:23433608 CST11 0.42 7.99 0.4 2.19e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs72634258 0.842 rs6577463 chr1:8169485 T/G cg00042356 chr1:8021962 PARK7 -0.59 -7.17 -0.37 4.76e-12 Inflammatory bowel disease; LUSC cis rs10791323 0.572 rs10791334 chr11:133735810 A/C cg15485101 chr11:133734466 NA 0.39 6.95 0.36 1.95e-11 Childhood ear infection; LUSC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg01770232 chr7:22766155 IL6 0.41 5.92 0.31 7.96e-9 Lung cancer; LUSC cis rs2777491 0.915 rs16971767 chr15:41623308 T/C cg18705301 chr15:41695430 NDUFAF1 -0.75 -14.12 -0.61 7.8e-36 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03666316 chr5:76012246 F2R 0.42 6.38 0.33 5.98e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11158026 0.575 rs8008150 chr14:55421436 G/T cg04306507 chr14:55594613 LGALS3 0.36 6.42 0.33 4.8e-10 Parkinson's disease; LUSC trans rs2204008 0.837 rs11168387 chr12:37962818 G/A cg06521331 chr12:34319734 NA 0.4 6.36 0.33 6.46e-10 Bladder cancer; LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg16606324 chr3:10149918 C3orf24 0.62 8.87 0.44 4.41e-17 Alzheimer's disease; LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg02018176 chr4:1364513 KIAA1530 0.52 9.16 0.45 5.47e-18 Obesity-related traits; LUSC cis rs6977660 0.714 rs28605851 chr7:19815219 G/A cg07541023 chr7:19748670 TWISTNB 0.66 7.21 0.37 3.71e-12 Thyroid stimulating hormone; LUSC cis rs654950 0.776 rs2759252 chr1:42021854 G/A cg06885757 chr1:42089581 HIVEP3 -0.45 -8.72 -0.43 1.32e-16 Airway imaging phenotypes; LUSC cis rs4595586 0.505 rs12826314 chr12:39379435 A/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg27266060 chr8:22091797 NA 0.39 7.18 0.37 4.61e-12 Hypertriglyceridemia; LUSC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg16586182 chr3:47516702 SCAP -0.52 -7.99 -0.4 2.18e-14 Colorectal cancer; LUSC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg05368731 chr17:41323189 NBR1 0.93 15.61 0.65 1.19e-41 Menopause (age at onset); LUSC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.81 -0.43 6.8e-17 Lung cancer; LUSC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.52 0.46 3.59e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs77633900 0.614 rs157757 chr15:76855927 G/C cg21673338 chr15:77095150 SCAPER -0.78 -7.05 -0.36 1.03e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs72781680 0.699 rs72796125 chr2:23919169 C/T cg20701182 chr2:24300061 SF3B14 0.74 7.3 0.37 2.15e-12 Lymphocyte counts; LUSC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg04455712 chr21:45112962 RRP1B 0.48 9.09 0.45 8.9e-18 Mean corpuscular volume; LUSC cis rs9303401 0.659 rs12948133 chr17:56673602 T/C cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.07e-17 Cognitive test performance; LUSC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg08975724 chr8:8085496 FLJ10661 0.59 9.03 0.44 1.39e-17 Systolic blood pressure; LUSC cis rs12973672 0.812 rs12979792 chr19:35748706 A/G cg12095397 chr19:35769544 USF2 0.43 6.53 0.34 2.45e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6977660 0.714 rs17141882 chr7:19790217 C/T cg07541023 chr7:19748670 TWISTNB 0.67 7.32 0.37 1.88e-12 Thyroid stimulating hormone; LUSC trans rs1728785 0.901 rs11642189 chr16:68583990 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg21963583 chr11:68658836 MRPL21 0.55 8.28 0.41 3.08e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4499344 0.730 rs377044 chr19:33105951 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.8 12.31 0.56 5.87e-29 Mean platelet volume; LUSC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.59 0.38 3.1400000000000003e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs6060960 0.502 rs6089110 chr20:30486907 A/T cg06102403 chr20:30458708 TTLL9;DUSP15 0.44 5.78 0.3 1.75e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7659604 0.540 rs10007956 chr4:122700669 A/T cg19748678 chr4:122722346 EXOSC9 -0.48 -7.29 -0.37 2.29e-12 Type 2 diabetes; LUSC cis rs62577244 0.645 rs12001733 chr9:138431675 G/T cg14582108 chr9:138439003 OBP2A 0.41 7.81 0.39 7.3e-14 Subcutaneous adipose tissue (sex interaction);Subcutaneous adipose tissue; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg13560548 chr3:10150139 C3orf24 0.48 6.9 0.35 2.69e-11 Alzheimer's disease; LUSC cis rs2273669 0.667 rs79285264 chr6:109318279 G/T cg05315195 chr6:109294784 ARMC2 -0.55 -5.87 -0.31 1.03e-8 Prostate cancer; LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg02018176 chr4:1364513 KIAA1530 0.51 8.7 0.43 1.53e-16 Obesity-related traits; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg20295408 chr7:1910781 MAD1L1 -0.48 -7.04 -0.36 1.08e-11 Bipolar disorder and schizophrenia; LUSC cis rs72772090 0.539 rs111237997 chr5:96114953 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -6.55 -0.34 2.11e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6940638 0.956 rs12190473 chr6:27024687 C/T cg09904177 chr6:26538194 HMGN4 -0.46 -5.7 -0.3 2.66e-8 Intelligence (multi-trait analysis); LUSC cis rs7605827 0.866 rs2032692 chr2:15616847 A/G cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.36e-16 Educational attainment (years of education); LUSC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.54 -7.69 -0.39 1.62e-13 Tuberculosis; LUSC cis rs2249625 0.545 rs10498880 chr6:72882183 G/T cg18830697 chr6:72922368 RIMS1 0.37 7.42 0.38 9.84e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg17800788 chr1:21766015 NBPF3 0.3 5.81 0.3 1.49e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs1371867 0.846 rs2919471 chr8:101232701 T/C cg00191853 chr8:101177733 SPAG1 0.41 6.61 0.34 1.5e-10 Atrioventricular conduction; LUSC trans rs28595532 0.557 rs12498329 chr4:119311524 C/T cg26518628 chr1:97050305 NA -0.6 -6.86 -0.35 3.44e-11 Cannabis dependence symptom count; LUSC cis rs2806561 0.765 rs623988 chr1:23519477 C/T cg12483005 chr1:23474871 LUZP1 0.41 6.5 0.34 2.89e-10 Height; LUSC cis rs9650657 0.529 rs10108618 chr8:10953092 A/G cg21775007 chr8:11205619 TDH -0.47 -7.18 -0.37 4.67e-12 Neuroticism; LUSC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg11608241 chr8:8085544 FLJ10661 -0.47 -6.51 -0.34 2.77e-10 Neuroticism; LUSC cis rs6840360 1.000 rs7439465 chr4:152594814 C/T cg22705602 chr4:152727874 NA 0.28 5.66 0.3 3.29e-8 Intelligence (multi-trait analysis); LUSC cis rs2303282 0.716 rs2219776 chr16:56399289 G/C cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs897984 0.645 rs9938550 chr16:30999142 A/G cg02466173 chr16:30829666 NA 0.56 11.11 0.52 1.3e-24 Dementia with Lewy bodies; LUSC cis rs1965732 1.000 rs1965732 chr2:3709108 A/G cg25251562 chr2:3704773 ALLC -0.39 -6.97 -0.36 1.71e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs453301 0.686 rs7017868 chr8:8873293 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.61 -0.38 2.74e-13 Joint mobility (Beighton score); LUSC cis rs12286929 0.609 rs45614535 chr11:115090866 G/A cg04055981 chr11:115044050 NA 0.37 6.63 0.34 1.39e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22270384 chr19:12848240 ASNA1 0.46 6.48 0.33 3.34e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg10130564 chr11:117069849 TAGLN 0.31 6.0 0.31 5.24e-9 Blood protein levels; LUSC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg25427524 chr10:38739819 LOC399744 0.7 12.69 0.57 2.16e-30 Extrinsic epigenetic age acceleration; LUSC cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC cis rs11608355 0.508 rs11066394 chr12:109799212 C/A cg19025524 chr12:109796872 NA -0.47 -8.59 -0.43 3.47e-16 Neuroticism; LUSC cis rs8060686 0.623 rs7205935 chr16:68152157 A/G cg05110241 chr16:68378359 PRMT7 -0.45 -5.96 -0.31 6.5e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg15110403 chr19:17392923 ANKLE1 -0.59 -7.94 -0.4 3.09e-14 Systemic lupus erythematosus; LUSC cis rs911555 0.574 rs34251103 chr14:103860063 A/G cg12935359 chr14:103987150 CKB 0.65 10.51 0.5 1.67e-22 Intelligence (multi-trait analysis); LUSC cis rs4499344 0.633 rs259258 chr19:33152523 A/G cg22980127 chr19:33182716 NUDT19 -0.44 -6.45 -0.33 3.88e-10 Mean platelet volume; LUSC cis rs17401966 1.000 rs2275424 chr1:10356562 C/A cg19773385 chr1:10388646 KIF1B -0.54 -8.32 -0.41 2.24e-15 Hepatocellular carcinoma; LUSC cis rs2267137 0.868 rs5763178 chr22:29773869 A/G cg07256473 chr22:29710276 RASL10A 0.39 7.39 0.37 1.19e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg18964960 chr10:1102726 WDR37 -0.46 -6.21 -0.32 1.58e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs7605827 0.866 rs11689153 chr2:15533899 A/G cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15433164 chr3:25824899 NGLY1 -0.49 -6.69 -0.34 9.49e-11 Bipolar disorder and schizophrenia; LUSC cis rs4906332 1.000 rs12892062 chr14:103883512 A/G cg04998671 chr14:104000505 TRMT61A -0.46 -7.18 -0.37 4.47e-12 Coronary artery disease; LUSC cis rs9650315 0.866 rs13272414 chr8:57183609 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.02e-11 Height; LUSC cis rs7267979 1.000 rs761025 chr20:25426968 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.75 0.73 4.73e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg25019033 chr10:957182 NA -0.5 -6.56 -0.34 2e-10 Eosinophil percentage of granulocytes; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg22963979 chr7:1858916 MAD1L1 -0.56 -8.78 -0.43 8.5e-17 Bipolar disorder and schizophrenia; LUSC cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg23583168 chr7:148888333 NA -0.88 -16.78 -0.68 2.87e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs634534 0.561 rs613924 chr11:65769295 C/T cg17712092 chr4:129076599 LARP1B 0.69 10.37 0.49 5.1e-22 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs2880765 0.835 rs7178991 chr15:86050944 G/C cg13263323 chr15:86062960 AKAP13 -0.35 -5.81 -0.3 1.45e-8 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04575144 chr19:4067379 ZBTB7A -0.49 -6.71 -0.34 8.37e-11 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg26338869 chr17:61819248 STRADA 0.42 6.18 0.32 1.83e-9 Prudent dietary pattern; LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg20587970 chr11:113659929 NA 1.06 11.67 0.54 1.23e-26 Hip circumference adjusted for BMI; LUSC cis rs7584330 0.554 rs7573177 chr2:238444467 C/T cg14458575 chr2:238380390 NA -0.46 -6.21 -0.32 1.57e-9 Prostate cancer; LUSC cis rs73206853 0.764 rs58535454 chr12:111003457 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.54 0.38 4.6e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6089584 0.566 rs6061401 chr20:60607482 G/A cg24733560 chr20:60626293 TAF4 0.44 7.96 0.4 2.66e-14 Body mass index; LUSC cis rs3760982 0.565 rs3786956 chr19:44286829 C/T cg12072164 chr19:44306565 LYPD5 0.29 6.45 0.33 3.85e-10 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs2580764 0.566 rs2968827 chr2:55297629 C/G cg09592903 chr2:55203963 RTN4 0.46 9.13 0.45 6.74e-18 Mean platelet volume; LUSC cis rs13315871 0.929 rs7643185 chr3:58311158 A/C cg20936604 chr3:58311152 NA 0.65 6.56 0.34 2.08e-10 Cholesterol, total; LUSC cis rs11971779 0.680 rs7808740 chr7:139028955 G/T cg23387468 chr7:139079360 LUC7L2 0.41 6.2 0.32 1.64e-9 Diisocyanate-induced asthma; LUSC cis rs7100689 0.622 rs4933378 chr10:82147057 T/C cg01528321 chr10:82214614 TSPAN14 0.89 13.66 0.6 4.65e-34 Post bronchodilator FEV1; LUSC cis rs12579753 0.879 rs11115009 chr12:82165409 G/T cg07988820 chr12:82153109 PPFIA2 0.45 6.58 0.34 1.84e-10 Resting heart rate; LUSC cis rs12530845 0.524 rs7795267 chr7:135308455 C/G cg23117316 chr7:135346802 PL-5283 -0.56 -8.88 -0.44 4.11e-17 Red blood cell traits; LUSC cis rs61990749 0.597 rs6574391 chr14:78208121 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.62 6.59 0.34 1.76e-10 Fibroblast growth factor basic levels; LUSC trans rs853679 0.517 rs2275508 chr6:28094731 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.11 -0.32 2.83e-9 Depression; LUSC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.44 6.69 0.34 9.59e-11 Menarche (age at onset); LUSC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.73 11.26 0.52 3.72e-25 Lymphocyte counts; LUSC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.52e-8 Extrinsic epigenetic age acceleration; LUSC trans rs10435719 0.899 rs9693925 chr8:11789963 A/G cg14343924 chr8:8086146 FLJ10661 0.44 6.04 0.31 4.1e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs314370 0.951 rs6706 chr7:100471044 C/T cg10426581 chr7:100472382 SRRT 0.86 12.47 0.56 1.43e-29 Resting heart rate; LUSC cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg04586622 chr2:25135609 ADCY3 0.39 8.19 0.41 5.74e-15 Body mass index; LUSC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg21285383 chr16:89894308 SPIRE2 0.33 6.9 0.35 2.64e-11 Vitiligo; LUSC cis rs4704187 0.687 rs28376290 chr5:74454706 C/T cg03227963 chr5:74354835 NA 0.31 6.8 0.35 4.74e-11 Response to amphetamines; LUSC trans rs11098499 0.955 rs35197422 chr4:120169314 T/G cg25214090 chr10:38739885 LOC399744 0.47 6.86 0.35 3.32e-11 Corneal astigmatism; LUSC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg27121462 chr16:89883253 FANCA 0.56 9.12 0.45 6.95e-18 Vitiligo; LUSC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg08219700 chr8:58056026 NA 0.69 8.22 0.41 4.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs2625529 0.617 rs7175373 chr15:72203517 G/T cg16672083 chr15:72433130 SENP8 0.46 7.77 0.39 9.52e-14 Red blood cell count; LUSC cis rs10276381 1.000 rs10263857 chr7:28187284 C/G cg23620719 chr7:28220237 JAZF1 0.59 6.55 0.34 2.15e-10 Crohn's disease; LUSC cis rs67460515 0.892 rs2100238 chr3:161058055 T/A cg03342759 chr3:160939853 NMD3 -0.52 -7.46 -0.38 7.72e-13 Parkinson's disease; LUSC cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg18132916 chr6:79620363 NA -0.38 -5.71 -0.3 2.45e-8 Intelligence (multi-trait analysis); LUSC cis rs709400 0.930 rs57447494 chr14:104034569 G/A cg24130564 chr14:104152367 KLC1 -0.47 -6.72 -0.35 7.97e-11 Body mass index; LUSC cis rs3857536 0.842 rs2188591 chr6:66939511 A/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg20203395 chr5:56204925 C5orf35 -0.58 -8.39 -0.42 1.39e-15 Coronary artery disease; LUSC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.65 -0.47 1.32e-19 Bipolar disorder; LUSC cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg18681998 chr4:17616180 MED28 0.78 13.71 0.6 3.02e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg11764359 chr7:65958608 NA -0.72 -11.05 -0.52 2.15e-24 Aortic root size; LUSC cis rs9902453 0.967 rs12602258 chr17:28317657 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.55 0.42 4.42e-16 Coffee consumption (cups per day); LUSC cis rs2075371 0.501 rs1643051 chr7:134025372 A/G cg20476274 chr7:133979776 SLC35B4 -0.71 -12.09 -0.55 3.59e-28 Mean platelet volume; LUSC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.38e-21 Electroencephalogram traits; LUSC cis rs4077515 0.967 rs4567159 chr9:139277059 G/A cg14169450 chr9:139327907 INPP5E 0.42 7.28 0.37 2.45e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.68 -8.8 -0.43 7.34e-17 Chronic sinus infection; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg08888203 chr3:10149979 C3orf24 0.63 8.07 0.4 1.25e-14 Alzheimer's disease; LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg08067268 chr2:26466485 HADHB;HADHA -0.54 -8.04 -0.4 1.53e-14 Gut microbiome composition (summer); LUSC trans rs17685 0.753 rs10251863 chr7:75790192 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs7647973 0.626 rs2329021 chr3:49679072 G/A cg21659725 chr3:3221576 CRBN -0.68 -7.85 -0.39 5.77e-14 Menarche (age at onset); LUSC cis rs4380275 1.000 rs4359695 chr2:774214 G/C cg21665850 chr2:731073 NA 0.42 6.75 0.35 6.49e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC trans rs6502050 1.000 rs6502050 chr17:80058236 C/G cg07393940 chr7:158741817 NA -0.35 -6.18 -0.32 1.89e-9 Life satisfaction; LUSC cis rs59698941 0.891 rs72799497 chr5:132291148 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.31 -0.33 8.88e-10 Apolipoprotein A-IV levels; LUSC cis rs2486288 0.656 rs1719232 chr15:45572072 A/G cg14582100 chr15:45693742 SPATA5L1 -0.45 -8.07 -0.4 1.25e-14 Glomerular filtration rate; LUSC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg07741184 chr6:167504864 NA 0.44 7.73 0.39 1.29e-13 Crohn's disease; LUSC trans rs6952808 0.582 rs10479762 chr7:2045351 T/C cg04565464 chr8:145669602 NFKBIL2 -0.39 -6.54 -0.34 2.35e-10 Bipolar disorder and schizophrenia; LUSC cis rs559928 0.606 rs7941773 chr11:63952759 C/T cg24687543 chr11:63912206 MACROD1 0.46 5.73 0.3 2.24e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs8028313 0.731 rs7172055 chr15:67938334 G/C cg08079166 chr15:68083412 MAP2K5 0.35 6.19 0.32 1.8e-9 Obesity; LUSC cis rs2073300 0.609 rs3746737 chr20:23424638 C/T cg12062639 chr20:23401060 NAPB 0.98 8.38 0.42 1.5e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7296418 0.630 rs11608305 chr12:123791165 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.63 -0.34 1.34e-10 Platelet count; LUSC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.39 -6.19 -0.32 1.81e-9 Personality dimensions; LUSC cis rs12493885 0.818 rs61791544 chr3:153767504 T/A cg17054900 chr3:154042577 DHX36 -0.54 -5.8 -0.3 1.51e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg12432903 chr7:1882776 MAD1L1 -0.36 -5.82 -0.3 1.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg02574844 chr11:5959923 NA -0.49 -6.89 -0.35 2.72e-11 DNA methylation (variation); LUSC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg13206674 chr6:150067644 NUP43 0.62 10.12 0.48 3.53e-21 Lung cancer; LUSC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg21724239 chr8:58056113 NA 0.55 6.37 0.33 6.25e-10 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg16606324 chr3:10149918 C3orf24 0.62 9.38 0.46 1.05e-18 Alzheimer's disease; LUSC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg03806693 chr22:41940476 POLR3H 1.01 13.99 0.61 2.56e-35 Vitiligo; LUSC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg23625390 chr15:77176239 SCAPER 0.47 7.2 0.37 4.12e-12 Blood metabolite levels; LUSC cis rs7824557 0.602 rs11781375 chr8:11204532 A/G cg21775007 chr8:11205619 TDH 0.82 13.79 0.6 1.53e-34 Retinal vascular caliber; LUSC cis rs11690935 0.632 rs17581284 chr2:172659376 C/T cg13550731 chr2:172543902 DYNC1I2 0.57 8.95 0.44 2.53e-17 Schizophrenia; LUSC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.15 0.32 2.27e-9 Hip circumference adjusted for BMI; LUSC cis rs713587 0.776 rs3731623 chr2:25163783 T/C cg01884057 chr2:25150051 NA 0.39 8.72 0.43 1.37e-16 Body mass index in non-asthmatics; LUSC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.57 0.38 3.63e-13 Multiple sclerosis; LUSC cis rs7582180 0.629 rs11684516 chr2:100949883 C/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg06544989 chr22:39130855 UNC84B 0.34 6.0 0.31 5.19e-9 Menopause (age at onset); LUSC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg04362960 chr10:104952993 NT5C2 0.57 8.21 0.41 5.05e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg05025164 chr4:1340916 KIAA1530 0.55 8.55 0.42 4.38e-16 Obesity-related traits; LUSC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg19622623 chr12:86230825 RASSF9 -0.42 -5.82 -0.3 1.4e-8 Major depressive disorder; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg02018176 chr4:1364513 KIAA1530 0.55 10.06 0.48 5.73e-21 Longevity; LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg00149659 chr3:10157352 C3orf10 1.1 14.91 0.63 7.05e-39 Alzheimer's disease; LUSC cis rs6121246 0.559 rs6121038 chr20:30254773 T/G cg13852791 chr20:30311386 BCL2L1 0.96 14.88 0.63 9.14e-39 Mean corpuscular hemoglobin; LUSC cis rs11112613 0.938 rs2374513 chr12:106007300 C/T cg03607813 chr12:105948248 NA 0.68 9.08 0.45 9.54e-18 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs17125944 0.686 rs7147258 chr14:53337664 G/T cg00686598 chr14:53173677 PSMC6 -0.69 -6.71 -0.34 8.47e-11 Alzheimer's disease (late onset); LUSC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg06453172 chr10:134556979 INPP5A -0.49 -6.11 -0.32 2.78e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.8 0.47 4.26e-20 Personality dimensions; LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.71 0.3 2.54e-8 Menopause (age at onset); LUSC cis rs73198271 0.628 rs11781258 chr8:8589758 A/G cg01851573 chr8:8652454 MFHAS1 0.46 5.83 0.3 1.29e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6967385 0.560 rs10434998 chr7:12348375 C/T cg20607287 chr7:12443886 VWDE 0.5 7.51 0.38 5.53e-13 Response to taxane treatment (placlitaxel); LUSC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg21138405 chr5:131827807 IRF1 -0.56 -11.15 -0.52 8.99e-25 Asthma (sex interaction); LUSC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg06494592 chr3:125709126 NA -0.52 -6.01 -0.31 4.85e-9 Blood pressure (smoking interaction); LUSC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg10792982 chr14:105748885 BRF1 0.49 9.04 0.44 1.3e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs10186029 0.509 rs6435756 chr2:213941279 C/G cg08319019 chr2:214017104 IKZF2 -0.41 -6.02 -0.31 4.48e-9 Systemic sclerosis; LUSC cis rs7582180 0.764 rs11682748 chr2:100925934 C/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); LUSC cis rs6840360 0.718 rs2136960 chr4:152746189 A/G cg22705602 chr4:152727874 NA 0.29 6.26 0.32 1.21e-9 Intelligence (multi-trait analysis); LUSC cis rs950027 0.572 rs12910764 chr15:45609360 T/C cg26924012 chr15:45694286 SPATA5L1 -0.76 -11.69 -0.54 1.11e-26 Response to fenofibrate (adiponectin levels); LUSC cis rs9527 0.662 rs4919686 chr10:104592249 A/C cg05855489 chr10:104503620 C10orf26 0.63 8.73 0.43 1.25e-16 Arsenic metabolism; LUSC cis rs7267979 0.545 rs6050426 chr20:25178265 C/G cg08601574 chr20:25228251 PYGB 0.47 7.04 0.36 1.13e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg00108164 chr2:264199 ACP1;SH3YL1 -0.53 -8.07 -0.4 1.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs61931739 0.500 rs7310576 chr12:34474735 T/C cg06521331 chr12:34319734 NA -0.42 -6.77 -0.35 5.87e-11 Morning vs. evening chronotype; LUSC cis rs9837602 0.938 rs10511177 chr3:99724873 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -6.3 -0.33 9.55e-10 Breast cancer; LUSC cis rs1113500 0.933 rs3909076 chr1:108631760 T/C cg06207961 chr1:108661230 NA 0.4 7.45 0.38 8.2e-13 Growth-regulated protein alpha levels; LUSC trans rs2262909 0.719 rs12461632 chr19:22245089 G/A cg05197062 chr11:11642011 GALNTL4 0.57 7.89 0.4 4.28e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg01283332 chr5:1856932 NA -0.32 -6.12 -0.32 2.68e-9 Cardiovascular disease risk factors; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20231940 chr2:129075198 HS6ST1 0.67 5.94 0.31 7.03e-9 Cognitive performance; LUSC cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg12386194 chr3:101231763 SENP7 0.63 8.74 0.43 1.12e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1670533 1.000 rs935970 chr4:1045323 C/G cg27284194 chr4:1044797 NA -0.59 -8.51 -0.42 5.91e-16 Recombination rate (females); LUSC cis rs611744 0.507 rs2121900 chr8:109333542 T/C cg21045802 chr8:109455806 TTC35 0.48 7.13 0.36 6.36e-12 Dupuytren's disease; LUSC trans rs61931739 0.534 rs1826144 chr12:34094272 A/G cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg15448220 chr1:150897856 SETDB1 0.4 5.88 0.31 1e-8 Melanoma; LUSC cis rs3858526 0.834 rs10838993 chr11:5979221 T/C cg05234568 chr11:5960015 NA -0.63 -8.89 -0.44 3.78e-17 DNA methylation (variation); LUSC cis rs9467773 1.000 rs6903973 chr6:26499942 C/A cg05738196 chr6:26577821 NA 0.79 14.86 0.63 1.05e-38 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg04287289 chr16:89883240 FANCA 0.77 13.15 0.58 4.12e-32 Vitiligo; LUSC cis rs9303401 0.615 rs35288118 chr17:56600748 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.38 0.56 3.24e-29 Cognitive test performance; LUSC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs7264396 1.000 rs224435 chr20:34154087 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.19 -0.37 4.16e-12 Total cholesterol levels; LUSC cis rs950169 0.922 rs12912934 chr15:85114447 C/T cg12863693 chr15:85201151 NMB 0.34 6.97 0.36 1.73e-11 Schizophrenia; LUSC cis rs72960926 0.744 rs72950563 chr6:74912043 G/C cg03266952 chr6:74778945 NA -0.78 -6.22 -0.32 1.5e-9 Metabolite levels (MHPG); LUSC cis rs7215564 0.908 rs34199628 chr17:78661675 A/G cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC trans rs3857536 0.813 rs2093253 chr6:66937702 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg24692254 chr21:30365293 RNF160 -0.81 -14.84 -0.63 1.33e-38 Dental caries; LUSC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg12564285 chr5:131593104 PDLIM4 0.34 6.27 0.32 1.09e-9 Blood metabolite levels; LUSC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg18479299 chr3:125709523 NA -0.51 -5.77 -0.3 1.76e-8 Blood pressure (smoking interaction); LUSC cis rs713587 0.521 rs35177510 chr2:25089594 C/A cg01884057 chr2:25150051 NA 0.44 10.0 0.48 9.07e-21 Body mass index in non-asthmatics; LUSC cis rs1865760 1.000 rs3830057 chr6:25918510 G/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.78 0.35 5.42e-11 Height; LUSC cis rs921968 0.541 rs562510 chr2:219443001 A/C cg02176678 chr2:219576539 TTLL4 0.75 14.64 0.63 7.48e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs1559088 1.000 rs7256328 chr19:33558705 G/C cg03563238 chr19:33554763 RHPN2 -0.39 -6.16 -0.32 2.14e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9300255 0.602 rs1790131 chr12:123701010 G/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.78 11.36 0.53 1.62e-25 Multiple sclerosis; LUSC trans rs2562456 0.793 rs11672341 chr19:21507304 A/G cg00806126 chr19:22604979 ZNF98 -0.42 -5.99 -0.31 5.56e-9 Pain; LUSC trans rs9944715 1.000 rs8094070 chr18:43849640 G/A cg01718231 chr17:29326311 RNF135 -0.53 -7.51 -0.38 5.6e-13 Red cell distribution width;Mean corpuscular volume; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11556929 chr2:240323605 HDAC4 -0.43 -6.23 -0.32 1.4e-9 Electrocardiographic conduction measures; LUSC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.17 0.37 4.87e-12 Mean platelet volume; LUSC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg15664640 chr17:80829946 TBCD 0.63 11.19 0.52 6.99e-25 Breast cancer; LUSC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg00339695 chr16:24857497 SLC5A11 0.61 9.65 0.47 1.37e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11890956 chr21:40555474 PSMG1 1.04 21.05 0.76 3.17e-63 Cognitive function; LUSC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg12288994 chr5:1860383 NA 0.29 6.27 0.32 1.1e-9 Cardiovascular disease risk factors; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05329982 chr11:62359210 TUT1 0.41 6.41 0.33 5.08e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg00999904 chr2:3704751 ALLC -0.44 -6.76 -0.35 6.12e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.96 -0.31 6.34e-9 Platelet count; LUSC cis rs2797160 1.000 rs1777222 chr6:126021030 C/T cg05901451 chr6:126070800 HEY2 0.57 8.79 0.43 8.07e-17 Endometrial cancer; LUSC cis rs6964587 1.000 rs7791138 chr7:91686789 A/G cg17063962 chr7:91808500 NA 0.57 9.05 0.44 1.24e-17 Breast cancer; LUSC cis rs6882046 0.513 rs628158 chr5:88041781 G/A cg22951263 chr5:87985283 NA -0.47 -7.67 -0.39 1.88e-13 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC trans rs561341 0.882 rs28649357 chr17:30367190 A/G cg27661571 chr11:113659931 NA -0.63 -7.36 -0.37 1.41e-12 Hip circumference adjusted for BMI; LUSC cis rs1670533 0.932 rs13108207 chr4:1054218 C/T cg02018176 chr4:1364513 KIAA1530 0.44 6.11 0.32 2.72e-9 Recombination rate (females); LUSC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg05855489 chr10:104503620 C10orf26 0.58 9.41 0.46 8.41e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8170 0.603 rs10259 chr19:17430915 G/A cg04749549 chr19:17459798 NA -0.33 -5.96 -0.31 6.25e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC cis rs17401966 0.522 rs4845930 chr1:10319049 G/A cg19773385 chr1:10388646 KIF1B -0.37 -6.44 -0.33 4.16e-10 Hepatocellular carcinoma; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg16606324 chr3:10149918 C3orf24 0.57 8.34 0.42 1.98e-15 Alzheimer's disease; LUSC cis rs524023 1.000 rs11602903 chr11:64358241 A/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.1 -0.48 4.3e-21 Urate levels in obese individuals; LUSC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg06634786 chr22:41940651 POLR3H 0.49 6.05 0.31 3.88e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18758796 chr5:131593413 PDLIM4 -0.5 -8.28 -0.41 3.03e-15 Acylcarnitine levels; LUSC cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg10018233 chr7:150070692 REPIN1 0.38 6.75 0.35 6.37e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs10754283 0.967 rs1934045 chr1:90107799 A/C cg21401794 chr1:90099060 LRRC8C -0.63 -9.46 -0.46 5.59e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg08219700 chr8:58056026 NA 0.5 6.2 0.32 1.7e-9 Developmental language disorder (linguistic errors); LUSC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 7.05 0.36 1.03e-11 Intelligence (multi-trait analysis); LUSC trans rs62055045 0.528 rs57342394 chr16:71562859 G/A cg15281710 chr15:96890452 NA -0.46 -6.69 -0.34 9.43e-11 Schizophrenia; LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.44 -0.5 2.9e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC trans rs2243480 0.901 rs73142137 chr7:65343442 A/T cg10756647 chr7:56101905 PSPH 0.88 8.45 0.42 8.8e-16 Diabetic kidney disease; LUSC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg07636037 chr3:49044803 WDR6 1.06 17.28 0.69 3.09e-48 Parkinson's disease; LUSC cis rs1858037 0.836 rs2576923 chr2:65633884 A/G cg08085232 chr2:65598271 SPRED2 0.42 6.16 0.32 2.12e-9 Rheumatoid arthritis; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg00945038 chr17:61921165 SMARCD2 0.54 9.52 0.46 3.65e-19 Prudent dietary pattern; LUSC cis rs9309711 0.621 rs11127428 chr2:3471146 T/C cg15541040 chr2:3486749 NA -0.52 -7.6 -0.38 3.1e-13 Neurofibrillary tangles; LUSC cis rs13315871 1.000 rs11715445 chr3:58343888 T/C cg12435725 chr3:58293450 RPP14 -0.74 -7.81 -0.39 7.27e-14 Cholesterol, total; LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.33 -0.33 7.7e-10 Bipolar disorder and schizophrenia; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg18765753 chr7:1198926 ZFAND2A -0.47 -8.16 -0.41 6.97e-15 Longevity;Endometriosis; LUSC cis rs7223966 0.960 rs11659013 chr17:61869559 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.9 0.35 2.56e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg21770322 chr7:97807741 LMTK2 0.41 6.97 0.36 1.71e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9443189 0.570 rs529383 chr6:76297847 T/G cg01950844 chr6:76311363 SENP6 0.67 6.21 0.32 1.54e-9 Prostate cancer; LUSC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.75 -0.35 6.73e-11 Developmental language disorder (linguistic errors); LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.08 0.36 8.38e-12 Platelet count; LUSC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg05855489 chr10:104503620 C10orf26 -0.65 -9.58 -0.46 2.31e-19 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9303401 0.573 rs34097494 chr17:57171917 C/T cg25039879 chr17:56429692 SUPT4H1 0.67 8.85 0.44 5.03e-17 Cognitive test performance; LUSC cis rs2236918 0.664 rs1776158 chr1:242017658 C/T cg17736920 chr1:242011382 EXO1 0.4 6.3 0.33 9.5e-10 Menopause (age at onset); LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.31 -0.53 2.44e-25 Alzheimer's disease; LUSC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg22508957 chr16:3507546 NAT15 -0.41 -6.63 -0.34 1.37e-10 Body mass index (adult); LUSC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg08859206 chr1:53392774 SCP2 -0.46 -7.57 -0.38 3.73e-13 Monocyte count; LUSC cis rs3812762 0.871 rs2173999 chr11:8778077 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.34 5.84 0.3 1.24e-8 Hypospadias; LUSC cis rs7246967 0.673 rs4244915 chr19:22854138 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg05776053 chr2:74358815 NA 0.47 7.39 0.37 1.17e-12 Gestational age at birth (maternal effect); LUSC cis rs11051970 0.661 rs188979 chr12:32569684 G/T cg02745156 chr12:32552066 NA 0.39 7.1 0.36 7.54e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7909074 0.966 rs4268464 chr10:45401081 T/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.5 -0.42 6.42e-16 Mean corpuscular volume; LUSC cis rs735860 0.700 rs209524 chr6:53213226 G/C cg10236188 chr6:53219634 NA 0.39 5.82 0.3 1.42e-8 Glaucoma; LUSC cis rs12956009 0.518 rs4574017 chr18:44891703 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.44 0.33 4.13e-10 Educational attainment (years of education); LUSC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg14895029 chr7:2775587 GNA12 -0.41 -6.35 -0.33 6.89e-10 Height; LUSC cis rs17094222 0.504 rs11190661 chr10:102452136 C/T cg26540559 chr10:102447443 NA 0.52 8.85 0.44 5.07e-17 Body mass index;BMI (adjusted for smoking behaviour);Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs72674100 1.000 rs4075858 chr4:97991815 A/G cg09670535 chr1:18959427 PAX7 0.66 6.72 0.35 7.71e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11644478 chr21:40555479 PSMG1 -0.61 -9.53 -0.46 3.45e-19 Menarche (age at onset); LUSC cis rs9457247 0.544 rs6920858 chr6:167464630 G/A cg06454157 chr6:167490870 NA -0.3 -7.03 -0.36 1.19e-11 Crohn's disease; LUSC cis rs9326248 0.581 rs7120963 chr11:116830261 C/T cg20608306 chr11:116969690 SIK3 -0.39 -7.24 -0.37 3.06e-12 Blood protein levels; LUSC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg06221963 chr1:154839813 KCNN3 -0.6 -13.28 -0.59 1.34e-32 Prostate cancer; LUSC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg00579200 chr11:133705235 NA -0.41 -5.97 -0.31 6.07e-9 Childhood ear infection; LUSC cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg06784218 chr1:46089804 CCDC17 0.54 11.13 0.52 1.06e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12136530 0.744 rs34929465 chr1:19777950 G/A cg01832549 chr1:19774989 CAPZB -0.33 -6.1 -0.32 2.96e-9 Lead levels in blood; LUSC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg23158103 chr7:148848205 ZNF398 -0.45 -6.88 -0.35 2.9e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg11764359 chr7:65958608 NA -0.78 -12.75 -0.57 1.29e-30 Aortic root size; LUSC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg01765077 chr12:122356316 WDR66 0.57 8.01 0.4 1.94e-14 Mean corpuscular volume; LUSC cis rs1775715 0.737 rs2808078 chr10:32172552 C/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.86 0.4 5.38e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.44 0.38 8.35e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg23711669 chr6:146136114 FBXO30 -0.83 -14.97 -0.63 3.94e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs116095464 0.558 rs9312957 chr5:202194 C/T cg22857025 chr5:266934 NA -1.2 -14.11 -0.61 8.51e-36 Breast cancer; LUSC cis rs4803468 1.000 rs878082 chr19:41897674 G/A cg09537434 chr19:41945824 ATP5SL -0.88 -15.75 -0.65 3.49e-42 Height; LUSC cis rs12155623 0.803 rs7011862 chr8:49817333 C/G cg22283653 chr8:49824208 NA 0.33 6.54 0.34 2.3e-10 Sudden cardiac arrest; LUSC cis rs6736093 0.862 rs35382200 chr2:112780716 G/C cg12686935 chr2:112915763 FBLN7 -0.4 -6.29 -0.33 1.01e-9 Coronary artery disease; LUSC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.54 -0.34 2.34e-10 Neutrophil percentage of white cells; LUSC cis rs11785400 1.000 rs4518642 chr8:143737396 T/C cg10596483 chr8:143751796 JRK 0.61 9.4 0.46 9.2e-19 Schizophrenia; LUSC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg11062466 chr8:58055876 NA 0.47 6.43 0.33 4.34e-10 Developmental language disorder (linguistic errors); LUSC cis rs4805272 0.512 rs17772319 chr19:29343064 T/A cg03161606 chr19:29218774 NA 0.51 5.96 0.31 6.3e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7528419 0.591 rs4970837 chr1:109822008 G/T cg00908766 chr1:109817496 CELSR2 0.57 9.57 0.46 2.56e-19 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; LUSC trans rs61931739 0.500 rs1601628 chr12:34047375 A/C cg13010199 chr12:38710504 ALG10B 0.53 7.95 0.4 2.82e-14 Morning vs. evening chronotype; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg16132339 chr22:24313637 DDTL;DDT 0.39 5.99 0.31 5.56e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg19230755 chr7:65878503 NA -0.41 -5.82 -0.3 1.37e-8 Aortic root size; LUSC cis rs3020736 0.500 rs6002601 chr22:42489058 A/T cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg03146154 chr1:46216737 IPP 0.56 8.5 0.42 6.44e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg27165867 chr14:105738592 BRF1 -0.52 -7.62 -0.38 2.61e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs9527 0.830 rs11191440 chr10:104641511 G/A cg23093090 chr10:104574429 C10orf26 -0.38 -6.55 -0.34 2.22e-10 Arsenic metabolism; LUSC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg12257692 chr3:49977190 RBM6 -0.24 -6.6 -0.34 1.66e-10 Intelligence (multi-trait analysis); LUSC cis rs7929679 0.521 rs10836304 chr11:34794024 C/T cg06937548 chr11:34938143 PDHX;APIP -0.39 -5.69 -0.3 2.76e-8 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs6430585 0.702 rs2304601 chr2:136528034 C/A cg07169764 chr2:136633963 MCM6 1.18 17.48 0.69 4.99e-49 Corneal structure; LUSC cis rs12575480 0.672 rs74048171 chr11:2093603 C/A cg15541987 chr11:2077307 NA -0.46 -7.11 -0.36 7.2e-12 Pursuit maintenance gain; LUSC cis rs7804356 0.569 rs112164743 chr7:26859172 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 2.01e-9 Type 1 diabetes; LUSC cis rs9916302 0.706 rs8069074 chr17:37685401 C/T cg07936489 chr17:37558343 FBXL20 0.83 10.52 0.5 1.47e-22 Glomerular filtration rate (creatinine); LUSC trans rs4332037 0.802 rs73048106 chr7:1929019 G/T cg25206134 chr2:45395956 NA 0.58 6.3 0.33 9.55e-10 Bipolar disorder; LUSC cis rs9487051 0.735 rs455839 chr6:109524221 G/A cg01475377 chr6:109611718 NA -0.34 -5.79 -0.3 1.65e-8 Reticulocyte fraction of red cells; LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg09877947 chr5:131593287 PDLIM4 0.51 7.88 0.4 4.63e-14 Acylcarnitine levels; LUSC cis rs4566357 0.557 rs2272201 chr2:227912551 T/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.27 -0.41 3.17e-15 Coronary artery disease; LUSC cis rs7177699 0.525 rs56076311 chr15:79115120 A/G cg00540400 chr15:79124168 NA -0.47 -8.16 -0.41 7.06e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs17253792 0.822 rs17685078 chr14:56127202 T/C cg01858014 chr14:56050164 KTN1 -0.79 -6.68 -0.34 9.73e-11 Putamen volume; LUSC cis rs3737883 1.000 rs11579558 chr1:203032038 G/T cg00805880 chr1:203045044 PPFIA4 -0.29 -5.81 -0.3 1.43e-8 Early onset atrial fibrillation; LUSC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg01416388 chr22:39784598 NA 0.44 7.0 0.36 1.4e-11 Intelligence (multi-trait analysis); LUSC cis rs7830933 1.000 rs7830933 chr8:23603324 A/G cg04349084 chr8:23602677 NA 0.37 5.88 0.31 9.79e-9 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; LUSC cis rs59698941 0.943 rs4705980 chr5:132286084 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs11785693 0.909 rs62489557 chr8:4968371 A/G cg26367366 chr8:4980734 NA 0.84 8.69 0.43 1.6e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.43e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9399135 0.660 rs4440481 chr6:135276696 A/G cg22676075 chr6:135203613 NA 0.53 8.49 0.42 6.96e-16 Red blood cell count; LUSC trans rs11098499 0.954 rs3890049 chr4:120326283 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.45 0.33 3.86e-10 Menopause (age at onset); LUSC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg13647721 chr17:30228624 UTP6 -0.65 -6.78 -0.35 5.44e-11 Hip circumference adjusted for BMI; LUSC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg19717773 chr7:2847554 GNA12 -0.39 -7.02 -0.36 1.24e-11 Height; LUSC trans rs459571 0.839 rs10993895 chr9:136887726 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 0.44 6.58 0.34 1.82e-10 Platelet distribution width; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.37 0.56 3.46e-29 Prudent dietary pattern; LUSC cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg12615879 chr12:58013172 SLC26A10 0.32 7.4 0.38 1.14e-12 Multiple sclerosis; LUSC cis rs2304069 0.659 rs216141 chr5:149443994 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.42 -5.71 -0.3 2.49e-8 HIV-1 control; LUSC trans rs4714291 0.963 rs847759 chr6:40024483 G/A cg02267698 chr19:7991119 CTXN1 0.53 7.23 0.37 3.33e-12 Strep throat; LUSC cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -5.91 -0.31 8.25e-9 Neuroticism; LUSC cis rs6845621 0.870 rs6818287 chr4:18934459 G/A cg12196642 chr4:18937545 NA -0.36 -6.66 -0.34 1.11e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs61931739 0.500 rs7965679 chr12:34542494 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg07636037 chr3:49044803 WDR6 1.06 17.05 0.68 2.56e-47 Parkinson's disease; LUSC cis rs9326248 1.000 rs7107152 chr11:117056080 C/T cg10130564 chr11:117069849 TAGLN -0.38 -6.56 -0.34 2.03e-10 Blood protein levels; LUSC cis rs2652834 0.851 rs11071721 chr15:63350218 T/C cg05507819 chr15:63340323 TPM1 0.67 8.43 0.42 1.03e-15 HDL cholesterol; LUSC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.2 0.41 5.41e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs9929218 0.551 rs3785135 chr16:68728976 A/C cg01251360 chr16:68772225 CDH1 0.26 6.24 0.32 1.3e-9 Colorectal cancer; LUSC cis rs9811920 0.809 rs4928235 chr3:99706870 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.59 -0.34 1.67e-10 Axial length; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.66 10.19 0.49 2.14e-21 Lymphocyte counts; LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.78 -0.3 1.68e-8 Platelet count; LUSC cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg17063962 chr7:91808500 NA 0.59 9.36 0.46 1.22e-18 Breast cancer; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.78 -11.3 -0.53 2.62e-25 Alzheimer's disease; LUSC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg05025164 chr4:1340916 KIAA1530 0.41 6.12 0.32 2.59e-9 Obesity-related traits; LUSC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg13047869 chr3:10149882 C3orf24 0.43 6.45 0.33 3.84e-10 Alzheimer's disease; LUSC cis rs7705502 1.000 rs56163845 chr5:173373948 A/G cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.3e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9473147 0.516 rs9369695 chr6:47440565 C/A cg12968598 chr6:47444699 CD2AP 0.53 7.85 0.39 5.65e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -7.72 -0.39 1.37e-13 Bone mineral density; LUSC cis rs9399401 0.667 rs34018047 chr6:142790873 G/C cg03128060 chr6:142623767 GPR126 0.58 9.61 0.47 1.8e-19 Chronic obstructive pulmonary disease; LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg25072359 chr17:41440525 NA 0.65 9.22 0.45 3.32e-18 Menopause (age at onset); LUSC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11890956 chr21:40555474 PSMG1 -0.81 -14.44 -0.62 4.5e-37 Cognitive function; LUSC cis rs17253792 0.822 rs77250916 chr14:56042208 A/G cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg08917208 chr2:24149416 ATAD2B 0.56 6.36 0.33 6.82e-10 Lymphocyte counts; LUSC cis rs17401966 1.000 rs17410793 chr1:10391886 A/G cg19773385 chr1:10388646 KIF1B -0.53 -8.21 -0.41 4.91e-15 Hepatocellular carcinoma; LUSC cis rs8060686 0.641 rs8060893 chr16:68191608 A/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs804280 0.509 rs9886639 chr8:11784529 G/T cg00405596 chr8:11794950 NA 0.35 5.79 0.3 1.64e-8 Myopia (pathological); LUSC cis rs354225 0.512 rs6744586 chr2:54930467 C/T cg26097391 chr2:54893211 SPTBN1 0.46 6.06 0.31 3.76e-9 Schizophrenia; LUSC cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.52 8.54 0.42 4.94e-16 IgG glycosylation; LUSC cis rs3862030 0.720 rs3740415 chr10:104232716 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.97 -0.44 2.15e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.87 -0.58 4.63e-31 Platelet count; LUSC cis rs9549367 0.789 rs9549718 chr13:113909822 A/G cg00898013 chr13:113819073 PROZ -0.54 -7.64 -0.39 2.31e-13 Platelet distribution width; LUSC cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg07930552 chr6:133119739 C6orf192 0.78 8.1 0.4 1.08e-14 Type 2 diabetes nephropathy; LUSC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg04414720 chr1:150670196 GOLPH3L 0.51 8.0 0.4 2.08e-14 Melanoma; LUSC cis rs10740039 0.734 rs10821815 chr10:62404601 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.86 -0.35 3.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs13089785 1.000 rs13081955 chr3:123600144 A/G cg02558132 chr3:123411198 MYLK 0.36 6.16 0.32 2.1e-9 Intelligence (multi-trait analysis); LUSC cis rs9420 0.961 rs7116341 chr11:57481155 G/A cg23127183 chr11:57508653 C11orf31 -0.58 -8.91 -0.44 3.41e-17 Schizophrenia; LUSC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.41 -6.27 -0.32 1.13e-9 Alzheimer's disease (late onset); LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg23978390 chr7:1156363 C7orf50 0.42 6.05 0.31 3.97e-9 Longevity;Endometriosis; LUSC trans rs11098499 0.754 rs878372 chr4:120238780 A/C cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg18252515 chr7:66147081 NA -1.25 -13.99 -0.61 2.56e-35 Diabetic kidney disease; LUSC cis rs7523050 0.643 rs34572569 chr1:109401856 A/T cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC trans rs9944715 0.954 rs7228365 chr18:43817832 A/G cg01718231 chr17:29326311 RNF135 -0.54 -7.74 -0.39 1.16e-13 Red cell distribution width;Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09455096 chr2:61765470 XPO1 0.44 6.27 0.32 1.13e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg08736216 chr1:53307985 ZYG11A 0.28 5.67 0.3 3.15e-8 Monocyte count; LUSC cis rs7727544 0.716 rs6863213 chr5:131575932 C/T cg24060327 chr5:131705240 SLC22A5 -0.39 -6.42 -0.33 4.82e-10 Blood metabolite levels; LUSC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg26597838 chr10:835615 NA 0.96 12.9 0.58 3.55e-31 Eosinophil percentage of granulocytes; LUSC cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg16346588 chr10:242978 ZMYND11 0.43 5.82 0.3 1.39e-8 Psychosis in Alzheimer's disease; LUSC cis rs1941023 0.584 rs2241921 chr11:60164302 C/T cg08716584 chr11:60157161 MS4A7 -0.65 -12.12 -0.55 2.81e-28 Congenital heart disease (maternal effect); LUSC cis rs1729951 0.575 rs1654923 chr3:136692620 A/T cg12473912 chr3:136751656 NA 0.39 6.81 0.35 4.51e-11 Neuroticism; LUSC cis rs6845621 0.553 rs60895903 chr4:18857218 T/C cg12196642 chr4:18937545 NA -0.31 -5.78 -0.3 1.72e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9300255 0.602 rs10846486 chr12:123709927 G/A cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs2288073 0.965 rs72789923 chr2:24394504 A/C cg06627628 chr2:24431161 ITSN2 -0.73 -9.93 -0.48 1.61e-20 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs1670533 1.000 rs651017 chr4:1091062 A/G cg27284194 chr4:1044797 NA 0.5 7.59 0.38 3.29e-13 Recombination rate (females); LUSC cis rs9837602 1.000 rs10212525 chr3:99713377 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.89 -0.31 9.26e-9 Breast cancer; LUSC cis rs34779708 0.931 rs11010083 chr10:35351531 C/G cg03585969 chr10:35415529 CREM 0.6 8.75 0.43 1.08e-16 Inflammatory bowel disease;Crohn's disease; LUSC trans rs3942852 0.545 rs10838798 chr11:48091303 T/G cg03929089 chr4:120376271 NA -0.58 -7.46 -0.38 7.43e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs7771547 0.573 rs621796 chr6:36472259 A/T cg07856975 chr6:36356162 ETV7 0.38 6.65 0.34 1.2e-10 Platelet distribution width; LUSC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg06850241 chr22:41845214 NA 0.31 5.8 0.3 1.56e-8 Vitiligo; LUSC trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs9462027 0.651 rs7748203 chr6:34812054 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.82 -0.3 1.35e-8 Systemic lupus erythematosus; LUSC cis rs4974559 0.739 rs2335937 chr4:1321516 C/A cg02980000 chr4:1222292 CTBP1 0.97 9.05 0.44 1.17e-17 Systolic blood pressure; LUSC cis rs60695258 0.550 rs340636 chr4:87930760 T/G cg10685359 chr4:87814065 C4orf36 0.34 6.04 0.31 4.09e-9 Hematocrit; LUSC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg06046430 chr4:77819534 ANKRD56 -0.48 -7.16 -0.36 5.32e-12 Emphysema distribution in smoking; LUSC cis rs1153858 0.723 rs1719238 chr15:45594766 C/T cg21132104 chr15:45694354 SPATA5L1 -0.53 -7.06 -0.36 9.9e-12 Homoarginine levels; LUSC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg19920283 chr7:105172520 RINT1 0.58 6.11 0.32 2.75e-9 Bipolar disorder (body mass index interaction); LUSC cis rs11148252 0.514 rs3783242 chr13:52717950 C/T cg00495681 chr13:53174319 NA 0.42 6.27 0.32 1.14e-9 Lewy body disease; LUSC cis rs722599 0.715 rs2300598 chr14:75359229 T/C cg08847533 chr14:75593920 NEK9 -0.47 -6.73 -0.35 7.6e-11 IgG glycosylation; LUSC cis rs9326248 1.000 rs7946257 chr11:117053165 A/G cg20608306 chr11:116969690 SIK3 0.41 6.87 0.35 3.08e-11 Blood protein levels; LUSC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg13607699 chr17:42295918 UBTF 0.75 13.86 0.6 8.11e-35 Red cell distribution width;Reticulocyte count; LUSC cis rs3125734 0.534 rs10821973 chr10:64052337 G/A cg19640130 chr10:64028056 RTKN2 -0.39 -6.8 -0.35 4.72e-11 Rheumatoid arthritis; LUSC cis rs13401104 0.796 rs10929171 chr2:237115622 G/A cg19324714 chr2:237145437 ASB18 0.43 5.65 0.3 3.43e-8 Educational attainment; LUSC cis rs300703 0.935 rs10167992 chr2:263270 C/T cg21211680 chr2:198530 NA -0.67 -7.1 -0.36 7.45e-12 Blood protein levels; LUSC cis rs9355610 0.727 rs2247315 chr6:167370211 A/C cg25258033 chr6:167368657 RNASET2 -0.36 -5.79 -0.3 1.63e-8 Graves' disease; LUSC cis rs6500602 0.627 rs3848372 chr16:4587875 C/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.42 6.26 0.32 1.17e-9 Schizophrenia; LUSC cis rs11785400 0.793 rs7017851 chr8:143722038 G/T cg24634471 chr8:143751801 JRK 0.5 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg14092988 chr3:52407081 DNAH1 -0.28 -5.7 -0.3 2.66e-8 Bipolar disorder; LUSC cis rs8017423 0.647 rs11626821 chr14:90824945 A/G cg04374321 chr14:90722782 PSMC1 -0.43 -6.44 -0.33 4.11e-10 Mortality in heart failure; LUSC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg07424592 chr7:64974309 NA -0.63 -5.66 -0.3 3.31e-8 Diabetic kidney disease; LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg18758796 chr5:131593413 PDLIM4 -0.42 -6.51 -0.34 2.77e-10 Blood metabolite levels; LUSC cis rs13315871 0.929 rs11130627 chr3:58315749 G/A cg12435725 chr3:58293450 RPP14 -0.74 -7.16 -0.36 5.16e-12 Cholesterol, total; LUSC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg03433033 chr1:76189801 ACADM -0.8 -12.64 -0.57 3.36e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg18252515 chr7:66147081 NA 1.21 13.5 0.59 1.92e-33 Diabetic kidney disease; LUSC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg24578937 chr1:2090814 PRKCZ -0.44 -9.86 -0.47 2.77e-20 Height; LUSC cis rs897984 0.609 rs55979739 chr16:31049155 A/G cg02466173 chr16:30829666 NA -0.54 -10.3 -0.49 8.9e-22 Dementia with Lewy bodies; LUSC cis rs7927592 0.913 rs7106010 chr11:68365212 C/T cg16797656 chr11:68205561 LRP5 0.38 6.2 0.32 1.67e-9 Total body bone mineral density; LUSC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg27535305 chr1:53392650 SCP2 -0.37 -6.33 -0.33 7.72e-10 Monocyte count; LUSC cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg18681998 chr4:17616180 MED28 -0.84 -15.64 -0.65 9.77e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.74 0.43 1.13e-16 Menopause (age at onset); LUSC cis rs10276381 0.786 rs73089302 chr7:28187134 G/A cg23620719 chr7:28220237 JAZF1 0.59 6.55 0.34 2.15e-10 Crohn's disease; LUSC trans rs12914656 0.556 rs8027956 chr15:86655875 A/C cg27136844 chr3:147142355 NA -0.39 -6.11 -0.32 2.77e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs62244186 0.535 rs59726036 chr3:44850074 G/T cg21672276 chr3:44754072 ZNF502 -0.38 -6.0 -0.31 5.26e-9 Depressive symptoms; LUSC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg20790798 chr5:1857306 NA -0.51 -8.7 -0.43 1.48e-16 Cardiovascular disease risk factors; LUSC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg01475377 chr6:109611718 NA -0.37 -6.46 -0.33 3.61e-10 Reticulocyte fraction of red cells; LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.69 -0.57 2.24e-30 Platelet count; LUSC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg09655341 chr17:79618100 PDE6G -0.29 -6.59 -0.34 1.67e-10 Eye color traits; LUSC cis rs2439831 0.850 rs2439832 chr15:43779686 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.83 0.43 6.08e-17 Lung cancer in ever smokers; LUSC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.59 11.7 0.54 1e-26 Monocyte percentage of white cells; LUSC cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg12011299 chr4:100065546 ADH4 0.71 10.71 0.51 3.44e-23 Smoking initiation; LUSC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.58e-8 Life satisfaction; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.7 10.57 0.5 9.88e-23 Lymphocyte counts; LUSC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg09455208 chr3:40491958 NA 0.52 9.42 0.46 7.87e-19 Renal cell carcinoma; LUSC cis rs2692947 0.800 rs61409777 chr2:96581373 C/A cg23100626 chr2:96804247 ASTL 0.26 6.39 0.33 5.48e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7072216 0.763 rs10748730 chr10:100171440 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs3106136 0.527 rs10016806 chr4:95158495 G/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.36 -0.42 1.68e-15 Capecitabine sensitivity; LUSC cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg10523860 chr14:103875565 MARK3 -0.39 -6.51 -0.34 2.72e-10 Body mass index; LUSC cis rs10266483 0.921 rs687547 chr7:63744929 A/G cg24201672 chr7:64023550 ZNF680 -0.48 -6.33 -0.33 7.83e-10 Response to statin therapy; LUSC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.31 0.41 2.37e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs6424115 0.830 rs2502995 chr1:24199290 T/C cg15997130 chr1:24165203 NA 0.52 8.58 0.42 3.67e-16 Immature fraction of reticulocytes; LUSC cis rs921968 0.613 rs1344642 chr2:219555262 G/A cg02176678 chr2:219576539 TTLL4 -0.6 -10.91 -0.51 6.45e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg01181863 chr3:195395398 SDHAP2 -0.6 -8.16 -0.41 7.12e-15 Pancreatic cancer; LUSC cis rs7481584 0.624 rs412149 chr11:3069943 G/A cg08508325 chr11:3079039 CARS 0.38 8.61 0.43 2.95e-16 Calcium levels; LUSC cis rs2573652 0.722 rs12903458 chr15:100542673 T/G cg00587665 chr15:100533223 ADAMTS17 -0.37 -6.65 -0.34 1.2e-10 Height; LUSC cis rs17155006 0.691 rs413412 chr7:107745399 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.37 -0.33 6.44e-10 Pneumococcal bacteremia; LUSC cis rs9303401 0.703 rs9911583 chr17:57210721 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.5 -7.69 -0.39 1.65e-13 Cognitive test performance; LUSC cis rs41271473 1.000 rs11583565 chr1:228880135 C/T cg16512390 chr1:228756714 NA 0.5 6.04 0.31 4.05e-9 Chronic lymphocytic leukemia; LUSC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg21963583 chr11:68658836 MRPL21 0.56 8.66 0.43 2.09e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs7824557 0.767 rs4559208 chr8:11153925 C/G cg08975724 chr8:8085496 FLJ10661 0.43 6.47 0.33 3.41e-10 Retinal vascular caliber; LUSC cis rs7106204 1.000 rs4244512 chr11:24217355 A/G ch.11.24196551F chr11:24239977 NA -0.99 -10.26 -0.49 1.18e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7605827 0.930 rs10184585 chr2:15683091 G/A cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs59104589 0.617 rs73002114 chr2:242280924 G/A cg14842376 chr2:242211374 HDLBP 0.52 5.95 0.31 6.85e-9 Fibrinogen levels; LUSC cis rs7100689 0.577 rs2342813 chr10:82046302 T/G cg01528321 chr10:82214614 TSPAN14 0.9 13.83 0.6 1.05e-34 Post bronchodilator FEV1; LUSC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg03732007 chr1:2071316 PRKCZ -0.52 -9.21 -0.45 3.64e-18 Height; LUSC cis rs11792861 0.926 rs72607173 chr9:111879398 T/G cg05043794 chr9:111880884 C9orf5 -0.32 -6.79 -0.35 5.01e-11 Menarche (age at onset); LUSC cis rs79349575 0.716 rs46522 chr17:46988597 C/T cg26022315 chr17:47021804 SNF8 0.37 5.75 0.3 2.02e-8 Type 2 diabetes; LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg04944784 chr2:26401820 FAM59B -0.66 -8.91 -0.44 3.33e-17 Gut microbiome composition (summer); LUSC cis rs6669072 1.000 rs6676886 chr1:91244343 C/G cg08895590 chr1:91227319 NA 0.39 8.54 0.42 4.97e-16 Cognitive function; LUSC cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg05347473 chr6:146136440 FBXO30 -0.53 -9.23 -0.45 3.12e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs11048434 0.736 rs2377672 chr12:9112414 A/G cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC cis rs7100689 0.599 rs6585968 chr10:82139807 T/C cg00277334 chr10:82204260 NA -0.5 -7.38 -0.37 1.28e-12 Post bronchodilator FEV1; LUSC trans rs7726839 0.540 rs57306627 chr5:597643 T/C cg25482853 chr8:67687455 SGK3 1.12 15.85 0.66 1.36e-42 Obesity-related traits; LUSC cis rs9650657 0.871 rs7814142 chr8:10637552 G/A cg27411982 chr8:10470053 RP1L1 -0.4 -6.56 -0.34 2.11e-10 Neuroticism; LUSC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg13939156 chr17:80058883 NA -0.33 -6.39 -0.33 5.53e-10 Life satisfaction; LUSC cis rs4906332 1.000 rs3783398 chr14:103949378 C/T cg04998671 chr14:104000505 TRMT61A 0.44 6.98 0.36 1.64e-11 Coronary artery disease; LUSC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg22029157 chr1:209979665 IRF6 0.77 9.48 0.46 4.95e-19 Cleft lip with or without cleft palate; LUSC trans rs4843747 0.671 rs4075599 chr16:88107423 C/G cg26811252 chr16:29126840 RRN3P2 0.56 8.92 0.44 3.23e-17 Menopause (age at onset); LUSC cis rs7264396 1.000 rs224433 chr20:34153850 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.83 -0.35 3.98e-11 Total cholesterol levels; LUSC cis rs72781680 0.898 rs56179550 chr2:23934867 C/T cg08917208 chr2:24149416 ATAD2B 1.0 10.16 0.49 2.55e-21 Lymphocyte counts; LUSC cis rs2486288 0.554 rs1719235 chr15:45576108 A/G cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.72 -0.51 3.1e-23 Glomerular filtration rate; LUSC cis rs983392 0.667 rs632185 chr11:59951433 A/G cg02771260 chr11:59836817 MS4A3 0.35 6.08 0.32 3.27e-9 Alzheimer's disease (late onset); LUSC cis rs7945718 1.000 rs12269900 chr11:12748518 G/A cg25843174 chr11:12811716 TEAD1 0.32 7.04 0.36 1.09e-11 Educational attainment (years of education); LUSC cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1801251 1.000 rs1446311 chr2:233705071 G/A cg25237894 chr2:233734115 C2orf82 -0.36 -6.81 -0.35 4.67e-11 Coronary artery disease; LUSC cis rs10779751 0.734 rs2791658 chr1:11127871 A/G cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs7572644 0.723 rs35679500 chr2:28019966 T/C cg27432699 chr2:27873401 GPN1 0.57 7.17 0.37 4.98e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg04455712 chr21:45112962 RRP1B 0.44 8.59 0.43 3.28e-16 Mean corpuscular volume; LUSC cis rs12760731 0.623 rs10465514 chr1:178334035 G/T cg00404053 chr1:178313656 RASAL2 0.47 5.75 0.3 2.03e-8 Obesity-related traits; LUSC cis rs9399401 0.925 rs9496374 chr6:142735221 G/C cg03128060 chr6:142623767 GPR126 0.34 6.1 0.32 2.95e-9 Chronic obstructive pulmonary disease; LUSC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 9.14 0.45 6.4e-18 Hip circumference adjusted for BMI; LUSC cis rs2708977 0.637 rs687950 chr2:97069612 C/G cg01950434 chr2:97203154 ARID5A 0.44 6.04 0.31 4.16e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22624212 chr21:44298959 WDR4 0.39 5.96 0.31 6.32e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs668210 0.793 rs586921 chr11:65747701 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.56 -7.08 -0.36 8.32e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg16447950 chr5:562315 NA -0.59 -7.06 -0.36 9.96e-12 Lung disease severity in cystic fibrosis; LUSC cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10189230 0.935 rs1864461 chr2:222347615 A/G cg14652038 chr2:222343519 EPHA4 0.36 6.38 0.33 5.83e-10 Urate levels in lean individuals; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25420398 chr3:133968920 RYK -0.38 -6.23 -0.32 1.4e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9815354 0.812 rs73071222 chr3:41986896 C/T cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg14092988 chr3:52407081 DNAH1 0.31 5.97 0.31 5.95e-9 Bipolar disorder; LUSC cis rs7954584 0.635 rs7313252 chr12:122347600 G/A cg21016266 chr12:122356598 WDR66 0.57 8.58 0.42 3.71e-16 Mean corpuscular volume; LUSC cis rs870825 0.860 rs28696121 chr4:185598743 G/A cg04058563 chr4:185651563 MLF1IP 0.84 12.67 0.57 2.58e-30 Blood protein levels; LUSC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.92 -0.31 7.93e-9 Neutrophil percentage of white cells; LUSC cis rs9807989 0.839 rs6543123 chr2:102977196 C/T cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.04 -0.48 6.9299999999999992e-21 Platelet count; LUSC cis rs7465272 0.530 rs10103161 chr8:143738571 A/G cg10596483 chr8:143751796 JRK 0.51 7.44 0.38 8.76e-13 Bipolar disorder and schizophrenia; LUSC cis rs13031619 1.000 rs6724730 chr2:3697987 G/C cg19052272 chr2:3704530 ALLC 0.45 7.95 0.4 2.91e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs11992162 0.573 rs61468577 chr8:11784925 A/C cg15556689 chr8:8085844 FLJ10661 -0.45 -6.38 -0.33 5.79e-10 Monocyte count; LUSC cis rs10791097 0.694 rs2236717 chr11:130739887 G/T cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.54e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2901656 0.591 rs9425304 chr1:172371151 C/A cg03748243 chr1:172413542 C1orf105;PIGC 0.31 6.0 0.31 5.11e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs4474465 0.646 rs7937417 chr11:78284470 A/G cg27205649 chr11:78285834 NARS2 0.56 6.78 0.35 5.39e-11 Alzheimer's disease (survival time); LUSC cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg08917208 chr2:24149416 ATAD2B 0.56 6.36 0.33 6.82e-10 Lymphocyte counts; LUSC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.8 0.47 4.22e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.48 6.46 0.33 3.74e-10 Renal function-related traits (BUN); LUSC cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg05347473 chr6:146136440 FBXO30 0.48 7.81 0.39 7.5e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg06238570 chr21:40685208 BRWD1 0.46 7.19 0.37 4.25e-12 Cognitive function; LUSC cis rs12681287 0.511 rs7839601 chr8:87503839 G/C cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs7666738 0.612 rs6830172 chr4:99093947 G/A cg03676636 chr4:99064102 C4orf37 0.29 6.13 0.32 2.49e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg19052272 chr2:3704530 ALLC -0.49 -8.19 -0.41 5.6e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg13206674 chr6:150067644 NUP43 0.57 8.99 0.44 1.91e-17 Lung cancer; LUSC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg24060327 chr5:131705240 SLC22A5 -0.52 -8.69 -0.43 1.61e-16 Breast cancer; LUSC cis rs9300255 0.602 rs2695479 chr12:123689386 T/C cg13010344 chr12:123464640 ARL6IP4 -0.48 -5.87 -0.31 1.04e-8 Neutrophil percentage of white cells; LUSC cis rs2282300 0.739 rs1222221 chr11:30342738 A/G cg25418670 chr11:30344373 C11orf46 -0.6 -8.68 -0.43 1.78e-16 Morning vs. evening chronotype; LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg18099408 chr3:52552593 STAB1 -0.41 -6.93 -0.35 2.17e-11 Bipolar disorder; LUSC cis rs1534166 0.507 rs3811657 chr3:133474607 C/T cg01448562 chr3:133502909 NA 0.51 5.7 0.3 2.57e-8 Alcohol consumption (transferrin glycosylation); LUSC cis rs7681440 0.869 rs7680557 chr4:90763360 C/A cg01966878 chr4:90757139 SNCA -0.36 -6.26 -0.32 1.2e-9 Dementia with Lewy bodies; LUSC cis rs3740713 0.669 rs113003553 chr11:18410861 T/C cg23797887 chr11:18477753 LDHAL6A -0.47 -5.77 -0.3 1.85e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6066835 1.000 rs2223684 chr20:47354880 A/C cg18078177 chr20:47281410 PREX1 0.7 6.17 0.32 1.99e-9 Multiple myeloma; LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg25072359 chr17:41440525 NA 0.64 8.97 0.44 2.23e-17 Menopause (age at onset); LUSC trans rs984440 0.534 rs984441 chr8:139077477 C/T cg03334052 chr1:168888044 NA 0.41 6.42 0.33 4.7e-10 Obesity-related traits; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10178905 chr15:63796301 USP3 -0.45 -6.02 -0.31 4.61e-9 Hepatitis; LUSC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Vitiligo; LUSC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs67460515 0.563 rs73023235 chr3:160864123 G/A cg03342759 chr3:160939853 NMD3 -0.48 -6.27 -0.32 1.09e-9 Parkinson's disease; LUSC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg18240062 chr17:79603768 NPLOC4 0.69 12.9 0.58 3.69e-31 Eye color traits; LUSC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg03948781 chr1:205179583 DSTYK 0.3 5.67 0.3 3.04e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg03146154 chr1:46216737 IPP -0.5 -7.24 -0.37 3.08e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg08859206 chr1:53392774 SCP2 0.46 7.75 0.39 1.13e-13 Monocyte count; LUSC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.6 -6.34 -0.33 7.44e-10 Glomerular filtration rate in chronic kidney disease; LUSC trans rs7746199 0.736 rs13215275 chr6:27647509 G/T cg06606381 chr12:133084897 FBRSL1 -0.95 -8.61 -0.43 2.88e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1348850 0.757 rs2166554 chr2:178455824 A/G cg22681709 chr2:178499509 PDE11A -0.46 -8.27 -0.41 3.25e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg20976159 chr1:228193529 WNT3A 0.28 5.79 0.3 1.59e-8 Diastolic blood pressure; LUSC cis rs11112613 0.609 rs17037380 chr12:106036708 C/T cg03607813 chr12:105948248 NA 0.63 8.02 0.4 1.8e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs853679 0.517 rs2281588 chr6:28072602 G/A cg06606381 chr12:133084897 FBRSL1 -0.47 -6.11 -0.32 2.77e-9 Depression; LUSC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg09367891 chr1:107599246 PRMT6 0.52 8.15 0.41 7.44e-15 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.72 0.6 2.68e-34 Alzheimer's disease; LUSC cis rs8141529 0.509 rs7287124 chr22:29239157 A/G cg15103426 chr22:29168792 CCDC117 0.48 6.36 0.33 6.61e-10 Lymphocyte counts; LUSC trans rs4332037 0.539 rs11764590 chr7:2032803 C/T cg10840412 chr1:235813424 GNG4 0.59 7.54 0.38 4.41e-13 Bipolar disorder; LUSC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.47 7.07 0.36 8.99e-12 Cognitive test performance; LUSC cis rs16910800 1.000 rs16910800 chr11:23202785 C/T cg20040320 chr11:23191996 NA -0.44 -6.35 -0.33 6.87e-10 Cancer; LUSC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg19729930 chr2:74357872 NA 0.89 16.82 0.68 2e-46 Gestational age at birth (maternal effect); LUSC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg06108461 chr20:60628389 TAF4 -0.75 -12.63 -0.57 3.75e-30 Body mass index; LUSC cis rs6964587 0.773 rs13223564 chr7:91932666 A/G cg17063962 chr7:91808500 NA 0.5 7.18 0.37 4.69e-12 Breast cancer; LUSC cis rs4363385 0.818 rs557553 chr1:153010370 T/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.2 -0.37 4.14e-12 Inflammatory skin disease; LUSC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg26695010 chr11:65641043 EFEMP2 -0.47 -6.83 -0.35 4.02e-11 Eosinophil percentage of white cells; LUSC cis rs1784581 0.802 rs9458430 chr6:162426517 G/T cg17173639 chr6:162384350 PARK2 -0.55 -8.99 -0.44 1.88e-17 Itch intensity from mosquito bite; LUSC cis rs6942756 1.000 rs7778277 chr7:128978805 C/T cg02491457 chr7:128862824 NA -0.47 -6.31 -0.33 9.1e-10 White matter hyperintensity burden; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01915076 chr12:49393228 DDN -0.51 -6.19 -0.32 1.71e-9 Bipolar disorder and schizophrenia; LUSC cis rs2635047 0.837 rs2571009 chr18:44650279 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 6.88 0.35 2.93e-11 Educational attainment; LUSC cis rs9325144 0.560 rs12424821 chr12:38649951 C/T cg13010199 chr12:38710504 ALG10B -0.51 -7.68 -0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg27284194 chr4:1044797 NA -0.36 -5.81 -0.3 1.44e-8 Obesity-related traits; LUSC cis rs76878669 0.515 rs12576299 chr11:66132286 T/C cg18002602 chr11:66138449 SLC29A2 0.45 8.12 0.41 8.95e-15 Educational attainment (years of education); LUSC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg21475434 chr5:93447410 FAM172A -0.71 -8.79 -0.43 8.1e-17 Diabetic retinopathy; LUSC cis rs6495367 1.000 rs1961579 chr15:79380516 G/A cg17916960 chr15:79447300 NA 0.35 6.6 0.34 1.64e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9549367 0.789 rs9549701 chr13:113881752 G/C cg18105134 chr13:113819100 PROZ -0.69 -9.77 -0.47 5.23e-20 Platelet distribution width; LUSC trans rs1728785 1.000 rs7205960 chr16:68565604 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs5769707 0.542 rs739242 chr22:50057116 A/G cg05373962 chr22:49881684 NA -0.4 -8.36 -0.42 1.77e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg00750074 chr16:89608354 SPG7 -0.58 -10.5 -0.5 1.77e-22 Multiple myeloma (IgH translocation); LUSC cis rs7914558 0.966 rs746293 chr10:104897254 G/T cg05855489 chr10:104503620 C10orf26 0.6 9.67 0.47 1.11e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10911363 0.549 rs12742245 chr1:183446922 T/A cg09173681 chr1:183549694 NCF2 0.63 11.37 0.53 1.54e-25 Systemic lupus erythematosus; LUSC cis rs10746514 0.804 rs11122429 chr1:232261532 G/A cg09506761 chr1:232265262 NA -0.57 -9.61 -0.47 1.77e-19 Response to statin therapy; LUSC trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg15704280 chr7:45808275 SEPT13 -0.63 -7.68 -0.39 1.83e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg09034736 chr1:150693464 HORMAD1 0.44 6.15 0.32 2.19e-9 Melanoma; LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg24813613 chr7:1882135 MAD1L1 -0.42 -6.92 -0.35 2.29e-11 Bipolar disorder and schizophrenia; LUSC cis rs11048434 0.736 rs2041625 chr12:9112005 C/T cg04155231 chr12:9217510 LOC144571 0.3 5.7 0.3 2.67e-8 Sjögren's syndrome; LUSC cis rs11758351 0.866 rs55815656 chr6:26207303 G/A cg01420254 chr6:26195488 NA 0.64 7.28 0.37 2.35e-12 Gout;Renal underexcretion gout; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09132500 chr16:3156381 NA 0.45 6.07 0.32 3.53e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.88 -0.51 8.12e-24 Schizophrenia; LUSC cis rs56399783 0.803 rs7811164 chr7:2822416 G/A cg19731401 chr7:2775893 GNA12 0.63 8.6 0.43 3.06e-16 Childhood ear infection; LUSC cis rs11608355 1.000 rs7958625 chr12:109869218 A/T cg05360138 chr12:110035743 NA 0.47 6.36 0.33 6.68e-10 Neuroticism; LUSC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.59 0.5 8.56e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC trans rs1728785 0.901 rs7194664 chr16:68643313 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.78 0.39 9.06e-14 Ulcerative colitis; LUSC cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.42 -0.38 9.65e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.61e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2439831 0.681 rs956391 chr15:43617493 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.88 -10.72 -0.51 3.02e-23 Lung cancer in ever smokers; LUSC cis rs12200560 0.505 rs211162 chr6:97067344 G/A cg06623918 chr6:96969491 KIAA0776 0.49 7.01 0.36 1.35e-11 Coronary heart disease; LUSC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 10.86 0.51 9.9e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4704187 0.687 rs4447963 chr5:74376309 A/C cg03227963 chr5:74354835 NA 0.31 6.67 0.34 1.09e-10 Response to amphetamines; LUSC trans rs71435601 0.628 rs494315 chr2:21400950 C/T cg20757404 chr19:378427 NA 0.37 5.96 0.31 6.28e-9 Cholesterol, total; LUSC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg17264618 chr3:40429014 ENTPD3 0.32 6.79 0.35 5.03e-11 Renal cell carcinoma; LUSC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg20573242 chr4:122745356 CCNA2 0.63 9.16 0.45 5.39e-18 Type 2 diabetes; LUSC cis rs7584330 0.736 rs6431541 chr2:238376190 A/T cg14458575 chr2:238380390 NA 0.65 11.57 0.53 2.91e-26 Prostate cancer; LUSC cis rs11809207 0.903 rs17257148 chr1:26526348 G/C cg19633962 chr1:26362018 EXTL1 -0.48 -5.82 -0.3 1.4e-8 Height; LUSC trans rs35110281 0.667 rs2250773 chr21:45087786 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.61 10.29 0.49 9.05e-22 Mean corpuscular volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03560797 chr7:106301641 FLJ36031 -0.44 -6.63 -0.34 1.36e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.06 -0.36 9.79e-12 Lung cancer; LUSC cis rs6426558 0.514 rs3754418 chr1:227348473 T/C cg10327440 chr1:227177885 CDC42BPA -0.53 -7.4 -0.38 1.12e-12 Neutrophil percentage of white cells; LUSC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.9 0.31 8.84e-9 Intelligence (multi-trait analysis); LUSC cis rs2115630 0.967 rs11073731 chr15:85355113 C/A cg09876464 chr15:85330779 ZNF592 0.36 6.67 0.34 1.07e-10 P wave terminal force; LUSC cis rs79149102 0.579 rs3910748 chr15:75318652 A/G cg09165964 chr15:75287851 SCAMP5 -0.93 -8.84 -0.44 5.7e-17 Lung cancer; LUSC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg13939156 chr17:80058883 NA -0.35 -7.04 -0.36 1.13e-11 Life satisfaction; LUSC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg18230493 chr5:56204884 C5orf35 -0.65 -10.25 -0.49 1.28e-21 Coronary artery disease; LUSC cis rs5758659 1.000 rs134902 chr22:42683997 C/T cg05082376 chr22:42548792 NA -0.37 -6.26 -0.32 1.18e-9 Cognitive function; LUSC cis rs2387326 0.717 rs10829336 chr10:129943532 T/C cg16087940 chr10:129947807 NA -0.39 -5.81 -0.3 1.48e-8 Select biomarker traits; LUSC cis rs1113500 0.565 rs1777455 chr1:108590288 C/A cg06207961 chr1:108661230 NA -0.35 -5.68 -0.3 2.98e-8 Growth-regulated protein alpha levels; LUSC cis rs3741151 0.773 rs73544767 chr11:73204619 C/T cg17517138 chr11:73019481 ARHGEF17 0.98 8.36 0.42 1.77e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4845570 0.834 rs13376155 chr1:151721270 A/G cg07092448 chr1:151763213 TDRKH -1.05 -10.92 -0.51 6.32e-24 Coronary artery disease; LUSC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg25554036 chr4:6271136 WFS1 0.59 12.29 0.56 6.97e-29 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4343996 0.934 rs4320450 chr7:3372308 G/C cg21248987 chr7:3385318 SDK1 -0.4 -6.75 -0.35 6.69e-11 Motion sickness; LUSC cis rs3126085 0.696 rs41266112 chr1:152185762 C/G cg03465714 chr1:152285911 FLG -0.42 -5.79 -0.3 1.64e-8 Atopic dermatitis; LUSC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg21951975 chr1:209979733 IRF6 0.57 6.9 0.35 2.68e-11 Cleft lip with or without cleft palate; LUSC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg16346588 chr10:242978 ZMYND11 0.4 5.67 0.3 3.15e-8 Psychosis in Alzheimer's disease; LUSC cis rs3741151 0.773 rs73544711 chr11:73164870 T/A cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1577917 0.740 rs2842604 chr6:86336300 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.0 -0.52 3.09e-24 Response to antipsychotic treatment; LUSC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg22834771 chr12:69754056 YEATS4 -0.43 -6.23 -0.32 1.37e-9 Blood protein levels; LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg01879757 chr17:41196368 BRCA1 -0.45 -6.98 -0.36 1.58e-11 Menopause (age at onset); LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg05552183 chr6:42928497 GNMT -0.47 -8.1 -0.41 1.07e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs41271473 1.000 rs11580020 chr1:228880466 A/G cg10167378 chr1:228756711 NA -0.55 -6.66 -0.34 1.15e-10 Chronic lymphocytic leukemia; LUSC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.77 -0.35 5.74e-11 Alzheimer's disease (late onset); LUSC cis rs10737909 0.510 rs12025158 chr1:15539259 A/G cg21012057 chr1:15538911 TMEM51 0.51 8.87 0.44 4.37e-17 Migraine; LUSC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.88 -14.34 -0.62 1.08e-36 Allergic disease (asthma, hay fever or eczema); LUSC trans rs2786098 0.656 rs12563879 chr1:197528805 T/A cg16005942 chr6:160526640 IGF2R 0.51 6.03 0.31 4.34e-9 Asthma; LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC trans rs853679 0.607 rs13203816 chr6:28079598 T/C cg01620082 chr3:125678407 NA -0.85 -7.28 -0.37 2.42e-12 Depression; LUSC cis rs61931739 0.500 rs12829125 chr12:34314789 A/G cg06521331 chr12:34319734 NA -0.48 -8.04 -0.4 1.53e-14 Morning vs. evening chronotype; LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg02018176 chr4:1364513 KIAA1530 -0.57 -9.84 -0.47 3.17e-20 Obesity-related traits; LUSC cis rs8016982 0.633 rs4363794 chr14:81674327 C/A cg01989461 chr14:81687754 GTF2A1 0.67 10.76 0.51 2.3e-23 Schizophrenia; LUSC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg08847533 chr14:75593920 NEK9 0.85 15.8 0.65 2.15e-42 Height; LUSC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg14019146 chr3:50243930 SLC38A3 0.31 6.59 0.34 1.69e-10 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.620 rs2504599 chr6:26641060 C/T cg05738196 chr6:26577821 NA 0.78 14.99 0.63 3.4e-39 Intelligence (multi-trait analysis); LUSC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg09367891 chr1:107599246 PRMT6 -0.5 -7.95 -0.4 2.84e-14 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.82 0.54 3.72e-27 Prudent dietary pattern; LUSC cis rs9467711 0.516 rs1165168 chr6:25859508 A/C cg08501292 chr6:25962987 TRIM38 0.57 5.8 0.3 1.53e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg22166914 chr1:53195759 ZYG11B -0.71 -12.23 -0.56 1.11e-28 Monocyte count; LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg14092988 chr3:52407081 DNAH1 0.31 6.18 0.32 1.85e-9 Bipolar disorder; LUSC cis rs6060717 0.536 rs6058364 chr20:34507890 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.74 -0.3 2.13e-8 Hip circumference adjusted for BMI; LUSC cis rs7208859 0.623 rs11658945 chr17:29122509 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11711311 0.784 rs13081931 chr3:113349928 G/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -5.69 -0.3 2.75e-8 IgG glycosylation; LUSC cis rs921665 0.681 rs6548169 chr2:3183752 A/G cg02624386 chr2:3182749 NA 0.63 6.34 0.33 7.32e-10 World class endurance athleticism; LUSC cis rs9611565 0.921 rs5751077 chr22:41720728 G/C cg03806693 chr22:41940476 POLR3H -0.7 -10.32 -0.49 7.64e-22 Vitiligo; LUSC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg13902645 chr11:5959945 NA 0.52 7.75 0.39 1.12e-13 DNA methylation (variation); LUSC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg07936489 chr17:37558343 FBXL20 -0.72 -9.93 -0.48 1.56e-20 Glomerular filtration rate (creatinine); LUSC cis rs2762353 0.935 rs1165195 chr6:25815080 T/G cg12310025 chr6:25882481 NA -0.44 -7.73 -0.39 1.25e-13 Blood metabolite levels; LUSC cis rs997295 0.713 rs17243334 chr15:68013079 A/G cg08079166 chr15:68083412 MAP2K5 -0.34 -6.7 -0.34 9.08e-11 Motion sickness; LUSC cis rs9430161 0.644 rs34365965 chr1:11034442 G/A cg27631724 chr1:11040367 C1orf127 0.54 9.56 0.46 2.75e-19 Ewing sarcoma; LUSC cis rs894734 0.535 rs2366143 chr12:54323256 G/A cg25024717 chr12:54324583 NA -0.38 -6.67 -0.34 1.07e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs9916302 0.706 rs9944459 chr17:37484185 T/C cg07936489 chr17:37558343 FBXL20 0.82 10.34 0.49 6.17e-22 Glomerular filtration rate (creatinine); LUSC cis rs2932538 0.922 rs6537745 chr1:113154080 T/C cg22162597 chr1:113214053 CAPZA1 0.53 7.54 0.38 4.39e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7917772 0.582 rs10786684 chr10:104323028 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.64 -10.6 -0.5 8.04e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs11098499 0.954 rs28429722 chr4:120300093 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs2979489 0.699 rs7840356 chr8:30406251 G/A cg26383811 chr8:30366931 RBPMS 0.48 7.58 0.38 3.43e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg14552801 chr7:65878734 NA -0.43 -5.89 -0.31 9.49e-9 Aortic root size; LUSC cis rs921968 0.613 rs2710251 chr2:219543433 T/C cg02176678 chr2:219576539 TTLL4 -0.58 -10.24 -0.49 1.42e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs1808579 0.904 rs1652348 chr18:21147509 C/T cg14672496 chr18:21087552 C18orf8 0.38 6.78 0.35 5.56e-11 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs7605827 0.897 rs4668899 chr2:15511575 C/A cg19274914 chr2:15703543 NA 0.46 8.95 0.44 2.45e-17 Educational attainment (years of education); LUSC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg21132104 chr15:45694354 SPATA5L1 0.57 8.14 0.41 7.67e-15 Homoarginine levels; LUSC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg03433033 chr1:76189801 ACADM 0.82 14.21 0.61 3.48e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7572644 0.640 rs4666024 chr2:28072979 C/G cg27432699 chr2:27873401 GPN1 -0.55 -7.62 -0.38 2.68e-13 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs877282 0.853 rs11596346 chr10:756673 A/T cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs1448094 0.717 rs7137122 chr12:86290702 T/C cg00310523 chr12:86230176 RASSF9 0.47 8.47 0.42 7.74e-16 Major depressive disorder; LUSC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg21361702 chr7:150065534 REPIN1 0.51 6.54 0.34 2.32e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs17030434 0.954 rs10000558 chr4:154766835 A/T cg14289246 chr4:154710475 SFRP2 -0.48 -6.32 -0.33 8.33e-10 Electrocardiographic conduction measures; LUSC cis rs17125944 1.000 rs17125944 chr14:53400629 C/T cg00686598 chr14:53173677 PSMC6 -0.79 -6.9 -0.35 2.56e-11 Alzheimer's disease (late onset); LUSC cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs9905704 0.681 rs1860262 chr17:56580997 T/C cg12560992 chr17:57184187 TRIM37 -0.51 -5.98 -0.31 5.73e-9 Testicular germ cell tumor; LUSC cis rs7647973 0.710 rs6797299 chr3:49609794 G/T cg13072238 chr3:49761600 GMPPB -0.69 -8.19 -0.41 5.44e-15 Menarche (age at onset); LUSC cis rs11608355 0.515 rs12822282 chr12:109923207 G/A cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC trans rs7737355 1.000 rs6872972 chr5:130621533 C/T cg07715041 chr7:99302981 CYP3A7 -0.39 -6.14 -0.32 2.3e-9 Life satisfaction; LUSC cis rs939658 0.967 rs7171067 chr15:79452727 G/T cg17916960 chr15:79447300 NA 0.48 9.62 0.47 1.64e-19 Refractive error; LUSC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg10356904 chr22:49881777 NA -0.33 -7.39 -0.37 1.21e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs868036 0.718 rs28587941 chr15:68122509 T/C cg08079166 chr15:68083412 MAP2K5 0.4 7.16 0.36 5.1e-12 Restless legs syndrome; LUSC trans rs7829975 0.686 rs907180 chr8:8702827 A/G cg21775007 chr8:11205619 TDH 0.46 6.73 0.35 7.52e-11 Mood instability; LUSC cis rs2458413 0.522 rs2514657 chr8:105331215 T/C cg04554929 chr8:105342491 NA -0.36 -6.38 -0.33 6.02e-10 Paget's disease; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg22963979 chr7:1858916 MAD1L1 -0.58 -8.97 -0.44 2.17e-17 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg20607798 chr8:58055168 NA 0.53 6.03 0.31 4.36e-9 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg18512352 chr11:47633146 NA -0.47 -9.31 -0.45 1.69e-18 Subjective well-being; LUSC trans rs12310956 0.515 rs115836245 chr12:33951369 T/C cg26384229 chr12:38710491 ALG10B 0.67 10.54 0.5 1.29e-22 Morning vs. evening chronotype; LUSC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.4 0.53 1.16e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs1941687 0.765 rs11874521 chr18:31391966 G/A cg27147174 chr7:100797783 AP1S1 -0.45 -6.48 -0.33 3.27e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs13191362 0.507 rs1079020 chr6:163066596 C/T cg14584255 chr6:163149320 PACRG;PARK2 -0.34 -6.52 -0.34 2.66e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs4720118 1.000 rs11972278 chr7:33431364 C/T cg18659248 chr10:3679062 NA -0.35 -6.02 -0.31 4.65e-9 Leprosy; LUSC cis rs896854 0.573 rs13271375 chr8:95853907 A/G cg23172400 chr8:95962367 TP53INP1 -0.36 -7.35 -0.37 1.52e-12 Type 2 diabetes; LUSC cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg27446573 chr6:127587934 RNF146 0.9 14.75 0.63 2.98e-38 Breast cancer; LUSC cis rs500891 0.525 rs6917851 chr6:84064190 A/C cg08257003 chr6:84140564 ME1 -0.32 -7.15 -0.36 5.68e-12 Platelet-derived growth factor BB levels; LUSC cis rs6693567 0.526 rs834239 chr1:150375458 C/A cg15654264 chr1:150340011 RPRD2 0.44 7.16 0.36 5.09e-12 Migraine; LUSC trans rs330071 0.686 rs10087406 chr8:9246598 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.66 -0.39 2.07e-13 Acne (severe); LUSC cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg22906224 chr7:99728672 NA 0.56 8.16 0.41 7.13e-15 Coronary artery disease; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg00166722 chr3:10149974 C3orf24 0.55 7.5 0.38 5.83e-13 Alzheimer's disease; LUSC cis rs9486719 0.895 rs3734239 chr6:96996244 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.74 -0.47 6.99e-20 Migraine;Coronary artery disease; LUSC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg05973401 chr12:123451056 ABCB9 0.56 8.2 0.41 5.16e-15 Platelet count; LUSC trans rs8072100 0.701 rs2013383 chr17:45791123 T/G cg04995722 chr7:26192034 NFE2L3 -0.42 -6.54 -0.34 2.32e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9910292 0.591 rs1076198 chr17:31350133 G/T cg03789507 chr8:136667083 NA 0.48 6.11 0.32 2.83e-9 Mosquito bite size; LUSC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg00012203 chr2:219082015 ARPC2 -0.7 -11.58 -0.54 2.72e-26 Colorectal cancer; LUSC cis rs2548003 0.518 rs2548006 chr5:28732126 C/T cg22863700 chr5:28928346 NA -0.47 -6.57 -0.34 1.95e-10 Hip geometry; LUSC cis rs7647973 0.925 rs6769821 chr3:49244657 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.47 6.65 0.34 1.17e-10 Menarche (age at onset); LUSC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg20203395 chr5:56204925 C5orf35 -0.49 -7.33 -0.37 1.78e-12 Breast cancer;Breast cancer (early onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08763126 chr6:109416997 C6orf182 0.45 5.98 0.31 5.83e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7903847 0.612 rs72838764 chr10:99142107 T/C cg20016023 chr10:99160130 RRP12 -0.28 -6.15 -0.32 2.17e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs17255340 0.520 rs1145913 chr6:83993928 A/C cg08257003 chr6:84140564 ME1 0.32 7.89 0.4 4.39e-14 Platelet-derived growth factor BB levels; LUSC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg17644776 chr2:200775616 C2orf69 0.54 9.5 0.46 4.09e-19 Osteoporosis; LUSC cis rs1355223 0.506 rs1509660 chr11:34865017 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.8 -0.35 4.79e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7191439 0.858 rs11076701 chr16:88774525 A/G cg02389323 chr16:88786976 FAM38A 1.13 10.71 0.51 3.41e-23 Plateletcrit; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg02951883 chr7:2050386 MAD1L1 -0.46 -7.92 -0.4 3.47e-14 Bipolar disorder and schizophrenia; LUSC cis rs61931739 0.534 rs6488189 chr12:33995865 C/T cg06521331 chr12:34319734 NA -0.46 -7.21 -0.37 3.82e-12 Morning vs. evening chronotype; LUSC cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg18132916 chr6:79620363 NA -0.38 -5.84 -0.3 1.23e-8 Intelligence (multi-trait analysis); LUSC cis rs9325144 0.600 rs11183505 chr12:38759110 G/T cg26384229 chr12:38710491 ALG10B -0.6 -9.23 -0.45 3.16e-18 Morning vs. evening chronotype; LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg08888203 chr3:10149979 C3orf24 0.6 8.62 0.43 2.68e-16 Alzheimer's disease; LUSC cis rs6460942 0.908 rs73677570 chr7:12280329 T/C cg06484146 chr7:12443880 VWDE -0.54 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs12908161 0.959 rs12906348 chr15:85329421 A/C cg17507749 chr15:85114479 UBE2QP1 0.54 6.5 0.34 2.86e-10 Schizophrenia; LUSC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg06618935 chr21:46677482 NA -0.39 -7.64 -0.39 2.28e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.21 0.59 2.34e-32 Total body bone mineral density; LUSC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg19774624 chr17:42201019 HDAC5 -0.78 -11.81 -0.54 4.03e-27 Total body bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00781875 chr1:156252398 TMEM79;SMG5 0.4 6.01 0.31 4.84e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7580658 0.963 rs9789510 chr2:128137012 G/A cg09760422 chr2:128146352 NA -0.33 -7.17 -0.37 4.89e-12 Protein C levels; LUSC cis rs8062405 0.964 rs62036614 chr16:28824685 T/C cg09754948 chr16:28834200 ATXN2L 0.45 6.45 0.33 3.87e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg04518342 chr5:131593106 PDLIM4 0.34 6.18 0.32 1.92e-9 Blood metabolite levels; LUSC cis rs68170813 0.559 rs17428126 chr7:106897037 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs9925964 0.967 rs14235 chr16:31121793 G/A cg02466173 chr16:30829666 NA 0.34 6.31 0.33 9.07e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg08677398 chr8:58056175 NA 0.57 6.89 0.35 2.79e-11 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.958 rs2875456 chr6:86602284 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.25e-17 Response to antipsychotic treatment; LUSC trans rs5756813 0.727 rs4820303 chr22:38134166 G/A cg19894588 chr14:64061835 NA -0.55 -7.29 -0.37 2.27e-12 Optic cup area;Vertical cup-disc ratio; LUSC cis rs7937682 1.000 rs505372 chr11:111507189 A/C cg22437258 chr11:111473054 SIK2 0.49 6.52 0.34 2.6e-10 Primary sclerosing cholangitis; LUSC cis rs2820315 0.931 rs2644114 chr1:201864830 A/G cg10061532 chr1:201886748 LMOD1 -0.27 -6.1 -0.32 2.98e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs317689 0.608 rs650198 chr12:69674595 C/T cg11871910 chr12:69753446 YEATS4 0.46 6.02 0.31 4.67e-9 Response to diuretic therapy; LUSC trans rs2840044 0.517 rs2124247 chr17:33885468 G/A cg19694781 chr19:47549865 TMEM160 -0.42 -6.73 -0.35 7.62e-11 Response to radiotherapy in cancer (late toxicity); LUSC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg09021430 chr5:549028 NA -0.54 -7.06 -0.36 9.57e-12 Lung disease severity in cystic fibrosis; LUSC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg18876405 chr7:65276391 NA 0.58 9.31 0.45 1.74e-18 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03448396 chr3:38495949 LOC100128640;ACVR2B 0.39 6.11 0.32 2.81e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg11764359 chr7:65958608 NA 0.74 11.65 0.54 1.5e-26 Aortic root size; LUSC cis rs62103177 0.564 rs11874805 chr18:77697110 T/C cg20368463 chr18:77673604 PQLC1 0.69 6.98 0.36 1.57e-11 Opioid sensitivity; LUSC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.38 5.89 0.31 9.29e-9 Platelet count; LUSC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg23978390 chr7:1156363 C7orf50 0.53 6.39 0.33 5.67e-10 Bronchopulmonary dysplasia; LUSC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg00631329 chr6:26305371 NA 0.32 5.66 0.3 3.33e-8 Intelligence (multi-trait analysis); LUSC cis rs9311676 0.632 rs6785572 chr3:58361517 A/G cg13750441 chr3:58318267 PXK -0.32 -6.23 -0.32 1.41e-9 Systemic lupus erythematosus; LUSC cis rs1957429 0.634 rs59000318 chr14:65419473 C/A cg23373153 chr14:65346875 NA -0.88 -9.18 -0.45 4.73e-18 Pediatric areal bone mineral density (radius); LUSC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg06634786 chr22:41940651 POLR3H 0.49 5.72 0.3 2.34e-8 Vitiligo; LUSC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.67e-9 Systolic blood pressure; LUSC cis rs7647973 1.000 rs9862534 chr3:49598064 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.5 7.89 0.4 4.49e-14 Menarche (age at onset); LUSC cis rs9326248 0.581 rs11216267 chr11:116952392 C/T cg11861562 chr11:117069780 TAGLN 0.33 6.35 0.33 7.23e-10 Blood protein levels; LUSC cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg01884057 chr2:25150051 NA 0.42 9.13 0.45 6.57e-18 Body mass index; LUSC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg18252515 chr7:66147081 NA 1.19 13.56 0.6 1.16e-33 Diabetic kidney disease; LUSC trans rs561341 0.883 rs7219239 chr17:30212016 A/G cg27661571 chr11:113659931 NA 0.59 6.41 0.33 4.92e-10 Hip circumference adjusted for BMI; LUSC cis rs11785693 0.862 rs11778367 chr8:4988398 T/C cg26367366 chr8:4980734 NA 0.77 9.11 0.45 7.89e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2235544 0.565 rs928441 chr1:54473368 C/A cg25741118 chr1:54482237 LDLRAD1 -0.28 -6.14 -0.32 2.4e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg03433033 chr1:76189801 ACADM -0.71 -9.73 -0.47 7.58e-20 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg04576048 chr1:205797593 PM20D1 0.34 6.13 0.32 2.51e-9 Menarche (age at onset); LUSC cis rs60843830 0.661 rs7588043 chr2:104979 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.44 6.62 0.34 1.43e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9512730 0.517 rs1967772 chr13:28036062 G/A cg08193333 chr13:27998609 GTF3A 0.45 5.65 0.3 3.44e-8 Schizophrenia; LUSC cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.49e-8 Breast cancer; LUSC cis rs2228479 0.681 rs7199685 chr16:89959805 G/C cg00800038 chr16:89945340 TCF25 -0.57 -6.14 -0.32 2.33e-9 Skin colour saturation; LUSC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg12560992 chr17:57184187 TRIM37 -0.83 -15.32 -0.64 1.65e-40 Intelligence (multi-trait analysis); LUSC cis rs4776059 0.798 rs28368342 chr15:52921573 A/G cg24008177 chr15:52972085 KIAA1370 -0.34 -6.26 -0.32 1.2e-9 Schizophrenia; LUSC cis rs734999 0.588 rs745368 chr1:2524205 C/T cg18854424 chr1:2615690 NA 0.49 9.67 0.47 1.15e-19 Ulcerative colitis; LUSC cis rs2742234 0.504 rs7093409 chr10:43740067 A/G cg15436174 chr10:43711423 RASGEF1A 0.38 6.78 0.35 5.41e-11 Hirschsprung disease; LUSC cis rs2742417 1.000 rs2673065 chr3:45771222 C/T cg04837898 chr3:45731254 SACM1L -0.37 -6.18 -0.32 1.9e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6582630 0.500 rs35251810 chr12:38577666 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.47 -0.33 3.56e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg22709100 chr7:91322751 NA 0.39 5.74 0.3 2.13e-8 Breast cancer; LUSC cis rs752010 0.875 rs11210502 chr1:42093712 A/C cg06885757 chr1:42089581 HIVEP3 0.47 9.83 0.47 3.52e-20 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.32 0.37 1.82e-12 Motion sickness; LUSC cis rs7843479 0.601 rs1058486 chr8:21862551 A/G cg17168535 chr8:21777572 XPO7 0.81 14.59 0.62 1.19e-37 Mean corpuscular volume; LUSC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs8073060 0.516 rs2376177 chr17:33938089 T/G cg19694781 chr19:47549865 TMEM160 -1.14 -18.49 -0.71 4.69e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs3931020 0.688 rs525487 chr1:75217420 A/G cg10128416 chr1:75198403 TYW3;CRYZ -0.64 -8.43 -0.42 1.02e-15 Resistin levels; LUSC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg01475377 chr6:109611718 NA -0.42 -7.65 -0.39 2.23e-13 Reticulocyte fraction of red cells; LUSC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg15448220 chr1:150897856 SETDB1 0.44 6.42 0.33 4.7e-10 Melanoma; LUSC cis rs9311676 0.656 rs3191903 chr3:58382846 C/T cg13750441 chr3:58318267 PXK 0.34 6.67 0.34 1.04e-10 Systemic lupus erythematosus; LUSC cis rs4589502 1.000 rs2414925 chr15:67129986 A/G cg09911534 chr15:67153556 NA -0.61 -6.64 -0.34 1.3e-10 Lung cancer (smoking interaction); LUSC cis rs6906287 0.647 rs2213856 chr6:118806793 C/T cg21191810 chr6:118973309 C6orf204 0.33 5.9 0.31 8.9e-9 Electrocardiographic conduction measures; LUSC cis rs1401999 0.510 rs3749438 chr3:183705184 G/A cg01324343 chr3:183735012 ABCC5 0.5 10.1 0.48 4.13e-21 Anterior chamber depth; LUSC cis rs983392 0.709 rs56273223 chr11:59984676 A/C cg24026212 chr11:59952134 MS4A6A -0.35 -6.09 -0.32 3.18e-9 Alzheimer's disease (late onset); LUSC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06022373 chr22:39101656 GTPBP1 0.74 11.63 0.54 1.84e-26 Menopause (age at onset); LUSC cis rs939574 0.790 rs2276635 chr2:220087441 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 6.14 0.32 2.39e-9 Platelet distribution width; LUSC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg00033643 chr7:134001901 SLC35B4 0.46 7.27 0.37 2.62e-12 Mean platelet volume; LUSC cis rs244731 0.959 rs7724098 chr5:176659570 G/A cg06060754 chr5:176797920 RGS14 -0.62 -8.75 -0.43 1.09e-16 Urate levels in lean individuals; LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs9420 0.961 rs11229131 chr11:57562525 G/A cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.22e-10 Schizophrenia; LUSC cis rs3106136 0.967 rs17310526 chr4:95222227 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.25 -0.32 1.29e-9 Capecitabine sensitivity; LUSC trans rs2832191 0.692 rs2245734 chr21:30359965 C/T cg14791747 chr16:20752902 THUMPD1 -0.42 -6.45 -0.33 4e-10 Dental caries; LUSC cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg12011299 chr4:100065546 ADH4 0.7 10.46 0.5 2.42e-22 Smoking initiation; LUSC cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg23649088 chr2:200775458 C2orf69 0.48 6.68 0.34 1.01e-10 Schizophrenia; LUSC trans rs11992162 0.621 rs13268810 chr8:11797430 A/T cg06636001 chr8:8085503 FLJ10661 0.46 6.38 0.33 5.76e-10 Monocyte count; LUSC cis rs240764 0.817 rs240143 chr6:101080621 G/A cg09795085 chr6:101329169 ASCC3 0.42 6.04 0.31 4.03e-9 Neuroticism; LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.1 -0.45 8.13e-18 Gut microbiome composition (summer); LUSC cis rs12122100 0.507 rs1925343 chr1:146505535 A/T cg02487331 chr1:146550467 NA -0.42 -7.41 -0.38 1.07e-12 HIV-1 control; LUSC cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg06219351 chr7:158114137 PTPRN2 -0.51 -9.23 -0.45 3.15e-18 Calcium levels; LUSC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.24 -0.32 1.32e-9 Bipolar disorder and schizophrenia; LUSC cis rs6712932 0.962 rs2053241 chr2:105842228 G/A cg26874229 chr2:105853672 NA -0.34 -6.06 -0.31 3.66e-9 Type 2 diabetes; LUSC cis rs79387448 0.745 rs17027430 chr2:103163237 T/C cg09003973 chr2:102972529 NA 0.89 8.62 0.43 2.69e-16 Gut microbiota (bacterial taxa); LUSC cis rs3849570 0.695 rs1851930 chr3:81895318 T/G cg07356753 chr3:81810745 GBE1 -0.58 -8.98 -0.44 2.08e-17 Waist circumference;Body mass index; LUSC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg04414720 chr1:150670196 GOLPH3L 0.5 7.36 0.37 1.49e-12 Urate levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10968375 chr5:55008210 SLC38A9 -0.45 -6.58 -0.34 1.78e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2236918 0.710 rs2526700 chr1:242019999 C/A cg17736920 chr1:242011382 EXO1 0.41 6.44 0.33 4.25e-10 Menopause (age at onset); LUSC cis rs2731664 0.756 rs2545796 chr5:176864269 T/C cg23176889 chr5:176863531 GRK6 -0.69 -14.24 -0.61 2.71e-36 Intelligence (multi-trait analysis); LUSC cis rs6430585 0.702 rs1042712 chr2:136545844 C/G cg07169764 chr2:136633963 MCM6 -1.11 -16.32 -0.67 2.01e-44 Corneal structure; LUSC cis rs4970988 0.526 rs6655975 chr1:150542128 A/G cg13175981 chr1:150552382 MCL1 0.45 5.8 0.3 1.52e-8 Urate levels; LUSC cis rs11642862 0.685 rs79974799 chr16:30996795 C/T cg02466173 chr16:30829666 NA -0.61 -6.47 -0.33 3.42e-10 Tonsillectomy; LUSC cis rs193541 0.593 rs154517 chr5:122189825 A/T cg19077854 chr5:122220652 SNX24 0.37 7.82 0.39 7.01e-14 Glucose homeostasis traits; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg21724239 chr8:58056113 NA 0.8 8.44 0.42 9.52e-16 Developmental language disorder (linguistic errors); LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg07507251 chr3:52567010 NT5DC2 0.31 6.12 0.32 2.65e-9 Bipolar disorder; LUSC cis rs11645898 0.810 rs72787060 chr16:72105371 T/C cg14768367 chr16:72042858 DHODH -0.69 -7.54 -0.38 4.37e-13 Blood protein levels; LUSC cis rs9303401 0.646 rs7342863 chr17:57227010 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.5 7.73 0.39 1.27e-13 Cognitive test performance; LUSC trans rs66887589 0.592 rs28580295 chr4:120278873 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.58 0.34 1.79e-10 Diastolic blood pressure; LUSC cis rs7712401 0.601 rs30029 chr5:122283170 A/C cg19077854 chr5:122220652 SNX24 -0.4 -9.01 -0.44 1.58e-17 Mean platelet volume; LUSC cis rs8060686 0.641 rs7204974 chr16:68033539 G/A cg04539111 chr16:67997858 SLC12A4 -0.41 -6.02 -0.31 4.72e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs3771570 1.000 rs56222556 chr2:242364119 G/A cg21155796 chr2:242212141 HDLBP 0.62 6.69 0.34 9.6e-11 Prostate cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04650641 chr22:41697410 ZC3H7B -0.49 -6.41 -0.33 4.99e-10 Hepatitis; LUSC cis rs1344694 0.566 rs13029765 chr2:216894976 A/T cg12620499 chr2:216877984 MREG 0.66 10.5 0.5 1.79e-22 Alcohol dependence; LUSC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg26380479 chr7:97908229 NA -0.27 -6.04 -0.31 4.06e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11711311 0.866 rs13313893 chr3:113400856 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.1 0.32 2.91e-9 IgG glycosylation; LUSC cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg06784218 chr1:46089804 CCDC17 -0.56 -11.07 -0.52 1.85e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7223966 1.000 rs11658740 chr17:61751069 A/G cg00945038 chr17:61921165 SMARCD2 0.38 5.67 0.3 3.13e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7089973 0.624 rs11196940 chr10:116593791 T/G cg23260525 chr10:116636907 FAM160B1 0.43 8.99 0.44 1.86e-17 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11051970 0.918 rs76930558 chr12:32538839 A/C cg02745156 chr12:32552066 NA 0.44 6.92 0.35 2.36e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg15556689 chr8:8085844 FLJ10661 0.57 8.31 0.41 2.38e-15 Neuroticism; LUSC cis rs9814567 1.000 rs9289471 chr3:134230811 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -13.75 -0.6 2.13e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12410462 0.681 rs79461024 chr1:227568783 G/T cg23173402 chr1:227635558 NA 0.56 6.28 0.32 1.07e-9 Major depressive disorder; LUSC cis rs9399135 1.000 rs4475342 chr6:135283348 T/C cg24558204 chr6:135376177 HBS1L 0.58 8.8 0.43 7.47e-17 Red blood cell count; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg05064044 chr6:292385 DUSP22 -0.73 -11.69 -0.54 1.11e-26 Menopause (age at onset); LUSC cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg22709100 chr7:91322751 NA 0.4 5.8 0.3 1.55e-8 Breast cancer; LUSC cis rs2985684 0.894 rs4900928 chr14:50020817 A/G cg04989706 chr14:50066350 PPIL5 -0.45 -6.1 -0.32 2.89e-9 Carotid intima media thickness; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06097977 chr7:150924442 ABCF2 0.44 5.98 0.31 5.9e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9788682 0.747 rs12101809 chr15:78779801 C/T cg24631222 chr15:78858424 CHRNA5 0.64 8.37 0.42 1.62e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9467711 0.591 rs3752417 chr6:26045905 G/C cg08501292 chr6:25962987 TRIM38 0.63 5.81 0.3 1.47e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs3784262 1.000 rs11071356 chr15:58240518 T/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.99 -0.31 5.54e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs184065563 1 rs184065563 chr6:45144224 G/A cg20913747 chr6:44695427 NA -0.46 -7.43 -0.38 8.91e-13 Total body bone mineral density (age over 60);Total body bone mineral density; LUSC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.27e-11 Lung cancer; LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg00814883 chr7:100076585 TSC22D4 -0.74 -9.91 -0.48 1.81e-20 Platelet count; LUSC cis rs73206853 0.563 rs34378671 chr12:111163204 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.52 0.38 5.1e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs11039798 1.000 rs11039978 chr11:48760237 A/G cg15704280 chr7:45808275 SEPT13 0.81 7.73 0.39 1.27e-13 Axial length; LUSC cis rs4780401 0.609 rs4780399 chr16:11828701 A/T cg01061890 chr16:11836724 TXNDC11 -0.56 -8.36 -0.42 1.78e-15 Rheumatoid arthritis; LUSC cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.13 0.66 1.08e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09969830 chr16:103646 SNRNP25;POLR3K -0.43 -6.23 -0.32 1.39e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11809207 1.000 rs11809207 chr1:26521140 G/A cg00300879 chr1:26503847 CNKSR1 0.3 5.82 0.3 1.34e-8 Height; LUSC cis rs2658782 0.654 rs2605623 chr11:93249359 A/G cg15737290 chr11:93063684 CCDC67 0.6 7.48 0.38 6.69e-13 Pulmonary function decline; LUSC trans rs7726839 0.794 rs11739663 chr5:594083 A/G cg25482853 chr8:67687455 SGK3 0.79 11.22 0.52 5.33e-25 Obesity-related traits; LUSC cis rs9467711 0.606 rs4634439 chr6:26598004 C/T cg09904177 chr6:26538194 HMGN4 0.67 6.34 0.33 7.59e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7215564 0.908 rs4889883 chr17:78664374 C/A cg23238734 chr17:78661607 RPTOR 0.48 6.12 0.32 2.63e-9 Myopia (pathological); LUSC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg09455208 chr3:40491958 NA 0.57 10.18 0.49 2.24e-21 Renal cell carcinoma; LUSC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 7.65 0.39 2.17e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.61e-29 Prudent dietary pattern; LUSC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg26039829 chr8:22132926 PIWIL2 0.44 8.15 0.41 7.24e-15 Hypertriglyceridemia; LUSC trans rs4650994 0.525 rs4650996 chr1:178517365 A/G cg05059571 chr16:84539110 KIAA1609 -0.47 -8.92 -0.44 3.1e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs6940638 0.715 rs9348751 chr6:27067190 T/A cg12826209 chr6:26865740 GUSBL1 0.53 7.68 0.39 1.8e-13 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.65e-13 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06626126 chr3:168865097 MECOM -0.36 -6.03 -0.31 4.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4363385 0.693 rs368076 chr1:153046514 A/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.39 -0.37 1.19e-12 Inflammatory skin disease; LUSC cis rs6987853 0.830 rs2272685 chr8:42354102 C/T cg09913449 chr8:42400586 C8orf40 -0.41 -6.76 -0.35 6.35e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg11764359 chr7:65958608 NA -0.8 -13.0 -0.58 1.56e-31 Aortic root size; LUSC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 8.98 0.44 2.02e-17 Height; LUSC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg03161606 chr19:29218774 NA 0.52 6.78 0.35 5.45e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs5758659 1.000 rs5751255 chr22:42648408 C/T cg05082376 chr22:42548792 NA -0.4 -6.62 -0.34 1.45e-10 Cognitive function; LUSC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.62 6.04 0.31 4.07e-9 Cerebrospinal P-tau181p levels; LUSC cis rs1322512 0.917 rs2758783 chr6:153010415 A/G cg27316956 chr6:152958899 SYNE1 0.36 6.19 0.32 1.76e-9 Tonometry; LUSC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg16405210 chr4:1374714 KIAA1530 -0.59 -9.24 -0.45 3e-18 Longevity; LUSC cis rs9929218 0.508 rs6499194 chr16:68744100 T/C cg01251360 chr16:68772225 CDH1 -0.25 -5.84 -0.3 1.23e-8 Colorectal cancer; LUSC cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg11984989 chr7:158649758 WDR60 -0.99 -17.38 -0.69 1.19e-48 Height; LUSC cis rs637571 0.510 rs10896052 chr11:65579600 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -5.8 -0.3 1.53e-8 Eosinophil percentage of white cells; LUSC trans rs208520 0.779 rs208451 chr6:66906155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.96 -12.9 -0.58 3.55e-31 Exhaled nitric oxide output; LUSC trans rs6600671 1.000 rs4844381 chr1:121184898 C/T cg00646200 chr1:148855367 NA 0.47 7.46 0.38 7.43e-13 Hip geometry; LUSC cis rs8077889 0.672 rs2074143 chr17:41856622 A/G cg26893861 chr17:41843967 DUSP3 1.11 23.99 0.8 1.25e-74 Triglycerides; LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg04944784 chr2:26401820 FAM59B 0.78 11.21 0.52 5.48e-25 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12568633 chr10:73533407 CDH23;C10orf54 -0.44 -6.05 -0.31 3.84e-9 Bipolar disorder and schizophrenia; LUSC cis rs12519773 0.526 rs4551051 chr5:92518724 T/C cg18783429 chr5:92414398 NA 0.33 7.22 0.37 3.44e-12 Migraine; LUSC cis rs3858526 0.834 rs7116627 chr11:5985550 T/C cg02574844 chr11:5959923 NA -0.46 -6.42 -0.33 4.8e-10 DNA methylation (variation); LUSC trans rs3857536 0.642 rs7755840 chr6:66891913 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC trans rs2898290 0.622 rs7829381 chr8:11344573 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.58 -0.42 3.56e-16 Systolic blood pressure; LUSC cis rs2294693 0.891 rs4714420 chr6:40992799 T/C cg14769373 chr6:40998127 UNC5CL -0.48 -7.0 -0.36 1.45e-11 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg03213289 chr20:61660250 NA 0.68 13.98 0.61 2.78e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs6076065 0.651 rs6114085 chr20:23419276 T/A cg11657817 chr20:23433608 CST11 0.41 7.45 0.38 7.97e-13 Facial morphology (factor 15, philtrum width); LUSC trans rs72792513 1.000 rs2339576 chr2:22920859 C/T cg05844895 chr16:88969569 CBFA2T3 0.5 6.2 0.32 1.69e-9 Hepatitis B; LUSC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg20891283 chr12:69753455 YEATS4 0.64 9.47 0.46 5.44e-19 Cerebrospinal fluid biomarker levels; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg25428297 chr7:1022841 CYP2W1 0.28 5.69 0.3 2.78e-8 Longevity;Endometriosis; LUSC trans rs61931739 0.517 rs12816423 chr12:34067736 G/A cg26384229 chr12:38710491 ALG10B 0.73 11.48 0.53 5.99e-26 Morning vs. evening chronotype; LUSC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg07701084 chr6:150067640 NUP43 0.58 9.04 0.44 1.31e-17 Lung cancer; LUSC trans rs4911259 0.552 rs6058926 chr20:31465450 T/C cg09781936 chr22:19749961 TBX1 -0.34 -6.01 -0.31 4.74e-9 Inflammatory bowel disease; LUSC cis rs9457247 0.663 rs1894603 chr6:167434686 C/T cg25258033 chr6:167368657 RNASET2 -0.37 -6.16 -0.32 2.06e-9 Crohn's disease; LUSC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg12463550 chr7:65579703 CRCP -0.43 -6.36 -0.33 6.61e-10 Aortic root size; LUSC cis rs4953318 0.619 rs12105417 chr2:46361255 A/C cg12428440 chr2:46370979 PRKCE 0.46 7.74 0.39 1.18e-13 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 3.09e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs8072100 0.782 rs62074054 chr17:45771816 T/C cg04995722 chr7:26192034 NFE2L3 -0.42 -6.45 -0.33 3.83e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg17554472 chr22:41940697 POLR3H 0.48 5.96 0.31 6.35e-9 Vitiligo; LUSC cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.75 0.7 4.07e-50 Chronic sinus infection; LUSC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg24549020 chr5:56110836 MAP3K1 0.48 5.81 0.3 1.45e-8 Initial pursuit acceleration; LUSC cis rs11098499 0.697 rs4373140 chr4:120307698 A/G cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs7586879 0.964 rs4077679 chr2:25122852 T/C cg15423357 chr2:25149977 NA 0.35 6.42 0.33 4.64e-10 Body mass index; LUSC trans rs198712 0.505 rs198311 chr7:24191762 T/C cg06529468 chr19:10676722 KRI1 0.38 6.1 0.32 2.89e-9 Aggressive periodontitis (sex interaction); LUSC trans rs459571 0.834 rs379417 chr9:136890704 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -12.48 -0.56 1.34e-29 Platelet distribution width; LUSC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22307029 chr19:49891270 CCDC155 0.61 7.78 0.39 9.21e-14 Multiple sclerosis; LUSC cis rs7094131 0.523 rs10828322 chr10:22876002 G/A cg19500236 chr10:22911537 PIP4K2A 0.35 6.01 0.31 4.98e-9 Obesity-related traits; LUSC cis rs1983891 1.000 rs2104506 chr6:41533579 C/A cg20194872 chr6:41519635 FOXP4 0.35 6.08 0.32 3.34e-9 Prostate cancer; LUSC cis rs9300255 0.510 rs1790133 chr12:123698518 T/G cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.92 -0.31 7.86e-9 Neutrophil percentage of white cells; LUSC cis rs3125734 0.633 rs6479791 chr10:63980341 T/C cg19640130 chr10:64028056 RTKN2 -0.41 -7.5 -0.38 5.67e-13 Rheumatoid arthritis; LUSC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg06112835 chr11:68658793 MRPL21 -0.5 -7.85 -0.39 5.84e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs1997103 1.000 rs6949222 chr7:55411264 C/T cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.47 -8.12 -0.41 8.96e-15 Lymphocyte counts; LUSC cis rs74181299 0.964 rs2540948 chr2:65284623 T/C cg05010058 chr2:65284262 CEP68 0.3 5.84 0.3 1.21e-8 Pulse pressure; LUSC cis rs6426558 0.502 rs6697665 chr1:227474665 T/C cg10327440 chr1:227177885 CDC42BPA 0.54 7.23 0.37 3.38e-12 Neutrophil percentage of white cells; LUSC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg20891283 chr12:69753455 YEATS4 0.81 14.65 0.63 7.13e-38 Blood protein levels; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg11494091 chr17:61959527 GH2 0.64 13.4 0.59 4.4e-33 Prudent dietary pattern; LUSC cis rs12188164 0.525 rs1114665 chr5:452247 C/T cg16584290 chr5:462447 EXOC3 0.47 8.29 0.41 2.85e-15 Cystic fibrosis severity; LUSC cis rs6456156 0.586 rs7746628 chr6:167483235 A/G cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs9322817 0.653 rs9399896 chr6:105216969 A/G cg02098413 chr6:105308735 HACE1 -0.28 -5.76 -0.3 1.9e-8 Thyroid stimulating hormone; LUSC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg18357526 chr6:26021779 HIST1H4A 0.45 7.01 0.36 1.31e-11 Intelligence (multi-trait analysis); LUSC cis rs6500602 0.702 rs11076835 chr16:4549618 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 6.81 0.35 4.45e-11 Schizophrenia; LUSC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg14668632 chr7:2872130 GNA12 -0.47 -6.89 -0.35 2.73e-11 Height; LUSC cis rs7909074 1.000 rs10900128 chr10:45393201 G/T cg05187965 chr10:45406764 TMEM72 -0.38 -9.0 -0.44 1.75e-17 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11890956 chr21:40555474 PSMG1 1.03 20.93 0.75 9.51e-63 Cognitive function; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg08472276 chr7:1133186 C7orf50;GPER -0.4 -6.5 -0.34 2.91e-10 Longevity;Endometriosis; LUSC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg03806693 chr22:41940476 POLR3H 0.99 14.13 0.61 7.12e-36 Vitiligo; LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 12.96 0.58 2.16e-31 Platelet count; LUSC cis rs752092 1.000 rs11247277 chr15:101784664 A/G cg19997662 chr15:101784653 CHSY1 -0.43 -6.07 -0.32 3.49e-9 Corneal structure; LUSC cis rs3771570 1.000 rs73018141 chr2:242221570 G/A cg21155796 chr2:242212141 HDLBP 0.68 7.51 0.38 5.46e-13 Prostate cancer; LUSC cis rs9486715 1.000 rs3798297 chr6:97062835 C/T cg06623918 chr6:96969491 KIAA0776 -0.85 -14.49 -0.62 3.04e-37 Headache; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21099776 chr17:17739742 SREBF1 0.4 6.04 0.31 4.11e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7789940 0.904 rs7459185 chr7:75934640 C/G cg15798862 chr7:76129360 DTX2 0.44 7.12 0.36 6.57e-12 Multiple sclerosis; LUSC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg22800045 chr5:56110881 MAP3K1 0.45 6.37 0.33 6.29e-10 Breast cancer;Breast cancer (early onset); LUSC cis rs6688613 0.729 rs2072742 chr1:166929673 A/G cg07049167 chr1:166818506 POGK 0.43 5.77 0.3 1.79e-8 Refractive astigmatism; LUSC cis rs72781680 0.756 rs2551337 chr2:24006886 C/T cg08917208 chr2:24149416 ATAD2B 0.63 7.16 0.36 5.01e-12 Lymphocyte counts; LUSC cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.05e-43 Bladder cancer; LUSC trans rs4714291 0.963 rs12194361 chr6:40116264 T/G cg02267698 chr19:7991119 CTXN1 -0.52 -7.24 -0.37 3.18e-12 Strep throat; LUSC trans rs11098499 0.954 rs6849171 chr4:120409549 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.8 0.39 7.9e-14 Corneal astigmatism; LUSC cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg07741184 chr6:167504864 NA 0.33 5.97 0.31 5.98e-9 Crohn's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16553447 chr15:77197883 NA -0.42 -6.05 -0.31 3.85e-9 Electrocardiographic conduction measures; LUSC cis rs6062509 0.811 rs6062498 chr20:62339059 C/G cg01176363 chr20:62369445 LIME1 -0.47 -7.09 -0.36 8.05e-12 Prostate cancer; LUSC cis rs66887589 0.967 rs3775842 chr4:120427732 G/A cg24375607 chr4:120327624 NA 0.48 7.36 0.37 1.41e-12 Diastolic blood pressure; LUSC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg12927641 chr6:109611667 NA -0.34 -5.72 -0.3 2.42e-8 Reticulocyte fraction of red cells; LUSC cis rs2279817 0.780 rs1124447 chr1:18007598 A/G cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.13 -0.32 2.54e-9 Neuroticism; LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs9287719 0.967 rs6432116 chr2:10748615 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs503341 0.756 rs626333 chr11:63591861 C/T cg04850017 chr11:63683019 RCOR2 0.3 6.03 0.31 4.28e-9 Pulse pressure; LUSC cis rs2625529 0.824 rs12593134 chr15:72303007 G/C cg16672083 chr15:72433130 SENP8 -0.51 -7.44 -0.38 8.7e-13 Red blood cell count; LUSC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg15017067 chr4:17643749 FAM184B 0.35 5.87 0.31 1.06e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg20744362 chr22:50050164 C22orf34 0.38 7.96 0.4 2.68e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1784581 0.651 rs1784590 chr6:162389462 C/A cg17173639 chr6:162384350 PARK2 -0.68 -12.13 -0.55 2.54e-28 Itch intensity from mosquito bite; LUSC trans rs747782 0.527 rs7113857 chr11:48141859 G/T cg15704280 chr7:45808275 SEPT13 0.7 6.49 0.33 3.05e-10 Intraocular pressure; LUSC cis rs13385 0.769 rs17118759 chr5:139617407 A/G cg26211634 chr5:139558579 C5orf32 0.44 6.86 0.35 3.4e-11 Atrial fibrillation; LUSC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg11764359 chr7:65958608 NA 0.7 10.95 0.51 4.71e-24 Aortic root size; LUSC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.61 0.43 2.95e-16 Height; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.49 -6.73 -0.35 7.34e-11 Renal function-related traits (BUN); LUSC cis rs1348850 0.561 rs57986285 chr2:178468663 C/T cg23306229 chr2:178417860 TTC30B 0.55 5.96 0.31 6.4e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC cis rs734999 0.588 rs2843404 chr1:2530558 T/C cg18854424 chr1:2615690 NA -0.49 -9.72 -0.47 8.17e-20 Ulcerative colitis; LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg05368731 chr17:41323189 NBR1 0.93 16.02 0.66 3e-43 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27656486 chr14:105635239 JAG2 -0.41 -6.01 -0.31 4.8e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs17685 0.725 rs6947068 chr7:75662056 T/C cg19862616 chr7:65841803 NCRNA00174 -1.14 -20.35 -0.74 1.94e-60 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.14e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg12311346 chr5:56204834 C5orf35 -0.95 -14.07 -0.61 1.2e-35 Initial pursuit acceleration; LUSC cis rs12368653 0.666 rs799265 chr12:58112189 A/G cg18357645 chr12:58087776 OS9 0.43 6.46 0.33 3.73e-10 Multiple sclerosis; LUSC trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg11887960 chr12:57824829 NA 0.55 7.07 0.36 9.13e-12 Lung disease severity in cystic fibrosis; LUSC cis rs9300255 0.516 rs6488868 chr12:123799974 A/G cg00376283 chr12:123451042 ABCB9 0.58 7.51 0.38 5.49e-13 Neutrophil percentage of white cells; LUSC cis rs2404602 0.692 rs57178708 chr15:76904069 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.09 -0.36 8.12e-12 Blood metabolite levels; LUSC cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg22529645 chr1:3704559 LRRC47 0.37 6.38 0.33 6.03e-10 Red cell distribution width; LUSC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg02423579 chr7:2872169 GNA12 -0.42 -6.43 -0.33 4.52e-10 Height; LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs10911232 0.507 rs4652769 chr1:183009196 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 11.01 0.52 2.94e-24 Hypertriglyceridemia; LUSC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg19774624 chr17:42201019 HDAC5 -0.73 -10.41 -0.5 3.56e-22 Total body bone mineral density; LUSC cis rs7759001 0.857 rs1022518 chr6:27364886 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs4566357 1.000 rs6436650 chr2:227925097 C/T cg11843606 chr2:227700838 RHBDD1 -0.44 -6.04 -0.31 4.1e-9 Coronary artery disease; LUSC cis rs9640161 0.658 rs74348353 chr7:150053655 C/A cg10018233 chr7:150070692 REPIN1 0.36 6.31 0.33 8.64e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg05340658 chr4:99064831 C4orf37 0.63 10.55 0.5 1.24e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.909 rs17046118 chr4:120387496 T/G cg09307838 chr4:120376055 NA 0.78 11.26 0.52 3.88e-25 Corneal astigmatism; LUSC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg12257692 chr3:49977190 RBM6 -0.26 -7.41 -0.38 1.03e-12 Body mass index; LUSC cis rs6582630 0.532 rs1589394 chr12:38419700 A/C cg26384229 chr12:38710491 ALG10B 0.67 10.4 0.49 3.99e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg04518342 chr5:131593106 PDLIM4 0.36 6.5 0.34 2.88e-10 Blood metabolite levels; LUSC cis rs10203711 1.000 rs6731675 chr2:239566943 T/C cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1577917 0.771 rs10944133 chr6:86358984 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.94 -0.51 5.23e-24 Response to antipsychotic treatment; LUSC cis rs11098499 0.954 rs67265404 chr4:120359270 C/T cg24375607 chr4:120327624 NA 0.79 11.78 0.54 5.25e-27 Corneal astigmatism; LUSC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.28 0.64 2.42e-40 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9815354 0.812 rs17218441 chr3:41987044 A/G cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs9399135 0.967 rs7750300 chr6:135350950 C/G cg22676075 chr6:135203613 NA 0.47 7.37 0.37 1.39e-12 Red blood cell count; LUSC cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg26597838 chr10:835615 NA 0.91 12.38 0.56 3.2e-29 Eosinophil percentage of granulocytes; LUSC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23221052 chr5:179740743 GFPT2 -0.66 -10.56 -0.5 1.09e-22 Height; LUSC cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg07148914 chr20:33460835 GGT7 0.54 8.38 0.42 1.53e-15 Height; LUSC cis rs7100689 0.753 rs2185426 chr10:82120887 G/A cg00277334 chr10:82204260 NA -0.49 -6.77 -0.35 5.89e-11 Post bronchodilator FEV1; LUSC cis rs478304 0.654 rs10896029 chr11:65452952 C/T cg05805236 chr11:65401703 PCNXL3 -0.63 -10.33 -0.49 6.71e-22 Acne (severe); LUSC cis rs11785400 0.793 rs4371985 chr8:143737279 C/T cg24634471 chr8:143751801 JRK 0.49 7.14 0.36 5.85e-12 Schizophrenia; LUSC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg04800585 chr6:26043546 HIST1H2BB 0.4 5.94 0.31 7e-9 Intelligence (multi-trait analysis); LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg08859206 chr1:53392774 SCP2 0.55 9.63 0.47 1.62e-19 Monocyte count; LUSC cis rs12101261 1.000 rs12101255 chr14:81451052 C/T cg06600135 chr14:81408086 NA 0.43 6.31 0.33 8.74e-10 Graves' disease; LUSC cis rs10744422 1.000 rs2292134 chr12:123334033 C/G cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.14e-12 Schizophrenia; LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg03352830 chr11:487213 PTDSS2 0.69 8.58 0.42 3.67e-16 Body mass index; LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs12579753 1.000 rs66646148 chr12:82248520 T/G cg07923666 chr12:49932857 KCNH3 -0.5 -6.15 -0.32 2.23e-9 Resting heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25913761 chr15:90727560 SEMA4B 0.43 6.85 0.35 3.61e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg22907277 chr7:1156413 C7orf50 0.72 10.44 0.5 2.92e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12200782 0.505 rs9295696 chr6:26550288 C/T cg05738196 chr6:26577821 NA 0.51 5.91 0.31 8.44e-9 Small cell lung carcinoma; LUSC cis rs3540 0.597 rs11639150 chr15:91042071 C/G cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.69 -0.3 2.8e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg11764359 chr7:65958608 NA 0.74 11.8 0.54 4.16e-27 Aortic root size; LUSC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg06494592 chr3:125709126 NA -0.52 -5.85 -0.3 1.16e-8 Blood pressure (smoking interaction); LUSC cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg05347473 chr6:146136440 FBXO30 0.46 7.97 0.4 2.52e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg22029157 chr1:209979665 IRF6 0.79 10.04 0.48 6.88e-21 Cleft lip with or without cleft palate; LUSC cis rs7577696 0.597 rs2280968 chr2:32290040 G/T cg02381751 chr2:32503542 YIPF4 -0.51 -6.88 -0.35 2.89e-11 Inflammatory biomarkers; LUSC cis rs12950390 0.853 rs11658511 chr17:45856918 T/C cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.51e-10 IgG glycosylation; LUSC cis rs7617773 0.780 rs34946886 chr3:48338487 A/G cg20734569 chr3:48348370 SPINK8 -0.46 -7.81 -0.39 7.43e-14 Coronary artery disease; LUSC trans rs3733585 0.699 rs4339211 chr4:9947658 C/T cg26043149 chr18:55253948 FECH -0.45 -6.85 -0.35 3.67e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs67072384 0.786 rs58424437 chr11:72448256 C/T cg04827223 chr11:72435913 ARAP1 -0.79 -7.25 -0.37 2.93e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs17685 0.753 rs10952840 chr7:75772878 C/T cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg22535103 chr8:58192502 C8orf71 -0.52 -6.1 -0.32 2.94e-9 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23634087 chr20:50721797 ZFP64 0.74 6.72 0.35 7.72e-11 Cognitive performance; LUSC trans rs4332037 0.950 rs11767515 chr7:1941051 C/T cg10840412 chr1:235813424 GNG4 0.68 9.13 0.45 6.54e-18 Bipolar disorder; LUSC cis rs11785400 1.000 rs4297023 chr8:143733307 C/A cg10596483 chr8:143751796 JRK 0.61 9.4 0.46 9.11e-19 Schizophrenia; LUSC cis rs4654899 0.758 rs2874367 chr1:21324491 A/C cg01072550 chr1:21505969 NA 0.47 7.3 0.37 2.19e-12 Superior frontal gyrus grey matter volume; LUSC cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg24812749 chr6:127587940 RNF146 -0.93 -14.02 -0.61 1.89e-35 Breast cancer; LUSC cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg07274523 chr3:49395745 GPX1 0.67 10.52 0.5 1.5e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2688608 0.839 rs2675662 chr10:75599127 A/G cg23231163 chr10:75533350 FUT11 0.37 5.78 0.3 1.72e-8 Inflammatory bowel disease; LUSC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg21573476 chr21:45109991 RRP1B -0.42 -6.84 -0.35 3.69e-11 Mean corpuscular volume; LUSC cis rs7267979 0.966 rs6083855 chr20:25405118 A/G cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2486288 0.656 rs11632752 chr15:45551140 A/G cg09092052 chr15:45571596 NA 0.46 6.36 0.33 6.52e-10 Glomerular filtration rate; LUSC trans rs11696501 0.694 rs7266372 chr20:44266635 T/C cg03272292 chr12:48577362 C12orf68 0.49 5.98 0.31 5.75e-9 Brain structure; LUSC cis rs1440088 0.732 rs13386066 chr2:198371687 C/T cg00982548 chr2:198649783 BOLL 0.49 6.28 0.33 1.02e-9 Ulcerative colitis; LUSC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg06618935 chr21:46677482 NA -0.4 -7.67 -0.39 1.92e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2354432 0.607 rs7511989 chr1:146720160 A/G cg25205988 chr1:146714368 CHD1L -1.01 -9.45 -0.46 6.1e-19 Mitochondrial DNA levels; LUSC cis rs10911232 0.507 rs10737239 chr1:183030170 A/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.01 0.52 2.93e-24 Hypertriglyceridemia; LUSC cis rs7605827 0.930 rs11675921 chr2:15569376 C/T cg19274914 chr2:15703543 NA -0.44 -8.29 -0.41 2.79e-15 Educational attainment (years of education); LUSC cis rs7903847 0.642 rs7909345 chr10:99150794 T/C cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.26e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs61990749 0.597 rs2267761 chr14:78147849 G/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.61 -6.55 -0.34 2.15e-10 Fibroblast growth factor basic levels; LUSC cis rs3087591 0.683 rs757375 chr17:29717879 C/G cg24425628 chr17:29625626 OMG;NF1 0.48 7.33 0.37 1.7e-12 Hip circumference; LUSC cis rs11098499 0.863 rs6833334 chr4:120504227 C/T cg09307838 chr4:120376055 NA 0.73 10.66 0.5 5.08e-23 Corneal astigmatism; LUSC cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1215050 0.791 rs548892 chr4:98724701 C/T cg05340658 chr4:99064831 C4orf37 0.43 6.84 0.35 3.74e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.34 -6.27 -0.32 1.14e-9 Monocyte percentage of white cells; LUSC cis rs9906944 0.624 rs2411759 chr17:47071074 C/T cg14634687 chr17:47094252 IGF2BP1 0.26 5.87 0.31 1.05e-8 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs317689 0.918 rs610192 chr12:69739941 T/C cg20891283 chr12:69753455 YEATS4 0.59 7.93 0.4 3.41e-14 Response to diuretic therapy; LUSC cis rs748404 0.631 rs7167882 chr15:43678663 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.46 6.73 0.35 7.37e-11 Lung cancer; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg15227302 chr7:135195347 CNOT4 0.39 5.96 0.31 6.55e-9 Schizophrenia; LUSC cis rs11098499 0.863 rs7699064 chr4:120428309 A/G cg09307838 chr4:120376055 NA -0.71 -10.12 -0.48 3.62e-21 Corneal astigmatism; LUSC cis rs477692 1.000 rs479478 chr10:131428959 G/A cg11019008 chr10:131425282 MGMT 0.4 6.0 0.31 5.17e-9 Response to temozolomide; LUSC cis rs8062405 0.755 rs7193402 chr16:28586127 A/G cg07382826 chr16:28625726 SULT1A1 0.27 5.75 0.3 2.06e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7542375 0.655 rs4846670 chr1:221069017 G/T cg16008148 chr1:221062819 NA 0.35 5.7 0.3 2.66e-8 Obesity-related traits; LUSC cis rs1595825 0.891 rs80178661 chr2:198582442 A/G cg00982548 chr2:198649783 BOLL -0.52 -6.67 -0.34 1.07e-10 Ulcerative colitis; LUSC cis rs17270561 0.609 rs1165211 chr6:25800922 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 6.56 0.34 2.02e-10 Iron status biomarkers; LUSC cis rs1371867 0.875 rs1962901 chr8:101326428 A/G cg00191853 chr8:101177733 SPAG1 -0.38 -6.36 -0.33 6.71e-10 Atrioventricular conduction; LUSC cis rs16854884 0.837 rs989665 chr3:143792854 C/T cg06585982 chr3:143692056 C3orf58 0.47 6.99 0.36 1.53e-11 Economic and political preferences (feminism/equality); LUSC cis rs7100689 0.646 rs10736348 chr10:82139244 C/A cg01528321 chr10:82214614 TSPAN14 0.85 12.98 0.58 1.85e-31 Post bronchodilator FEV1; LUSC cis rs12474201 0.832 rs11695058 chr2:46978349 A/G cg06386533 chr2:46925753 SOCS5 0.67 9.86 0.47 2.76e-20 Height; LUSC trans rs11098499 0.954 rs4577559 chr4:120404043 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 4.01e-10 Corneal astigmatism; LUSC cis rs11098499 1.000 rs11098500 chr4:120219239 T/A cg09307838 chr4:120376055 NA 0.76 11.0 0.52 3.07e-24 Corneal astigmatism; LUSC cis rs10197940 0.578 rs6718653 chr2:152346118 C/A cg06191203 chr2:152266755 RIF1 -0.43 -5.87 -0.31 1.04e-8 Lung cancer; LUSC cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg23711669 chr6:146136114 FBXO30 0.91 17.28 0.69 3.13e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs28735056 0.967 rs498541 chr18:77589655 G/A cg05926928 chr17:57297772 GDPD1 -0.48 -6.71 -0.34 8.57e-11 Schizophrenia; LUSC cis rs1003719 0.751 rs2835585 chr21:38460488 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.46 0.53 7.04e-26 Eye color traits; LUSC cis rs9790314 0.521 rs13084731 chr3:161086020 G/A cg03342759 chr3:160939853 NMD3 -0.41 -5.98 -0.31 5.71e-9 Morning vs. evening chronotype; LUSC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg11742103 chr11:62369870 EML3;MTA2 0.48 7.18 0.37 4.47e-12 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs734999 0.545 rs4474198 chr1:2553758 C/T cg18932078 chr1:2524107 MMEL1 0.28 6.22 0.32 1.51e-9 Ulcerative colitis; LUSC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg11764359 chr7:65958608 NA 0.74 11.8 0.54 4.16e-27 Aortic root size; LUSC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg11843238 chr5:131593191 PDLIM4 0.34 5.71 0.3 2.46e-8 Breast cancer; LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg08280861 chr8:58055591 NA 0.57 7.2 0.37 3.94e-12 Developmental language disorder (linguistic errors); LUSC cis rs9467773 0.596 rs2494693 chr6:26619226 T/C cg05738196 chr6:26577821 NA 0.79 15.24 0.64 3.59e-40 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg03060546 chr3:49711283 APEH 0.54 7.8 0.39 8.06e-14 Menarche (age at onset); LUSC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg13683864 chr3:40499215 RPL14 -1.14 -19.9 -0.74 1.12e-58 Renal cell carcinoma; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg06877462 chr1:205807181 PM20D1 0.53 9.91 0.48 1.79e-20 Menarche (age at onset); LUSC cis rs4964805 0.913 rs3812803 chr12:104200460 T/C cg02344784 chr12:104178138 NT5DC3 0.43 6.96 0.36 1.85e-11 Attention deficit hyperactivity disorder; LUSC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg21782813 chr7:2030301 MAD1L1 0.37 6.05 0.31 3.84e-9 Schizophrenia; LUSC trans rs35110281 0.626 rs10854486 chr21:45118280 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.63 0.5 6.24e-23 Mean corpuscular volume; LUSC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg13126279 chr21:47581558 C21orf56 -0.4 -5.78 -0.3 1.75e-8 Testicular germ cell tumor; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09113513 chr11:12695910 TEAD1 -0.36 -6.13 -0.32 2.53e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2294693 0.947 rs736795 chr6:40998141 G/A cg14769373 chr6:40998127 UNC5CL -0.56 -8.04 -0.4 1.54e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7412746 0.566 rs11204743 chr1:150890406 A/T cg15448220 chr1:150897856 SETDB1 0.42 5.78 0.3 1.73e-8 Melanoma; LUSC cis rs4363385 0.530 rs61815714 chr1:152921380 C/T cg00922841 chr1:152955080 SPRR1A -0.37 -6.06 -0.31 3.67e-9 Inflammatory skin disease; LUSC cis rs5167 0.601 rs73047694 chr19:45497852 G/A cg25746394 chr19:45450501 APOC2 0.31 5.77 0.3 1.83e-8 Blood protein levels; LUSC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg12963246 chr6:28129442 ZNF389 0.55 7.66 0.39 1.98e-13 Parkinson's disease; LUSC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg06850241 chr22:41845214 NA 0.31 5.8 0.3 1.56e-8 Vitiligo; LUSC cis rs394563 0.591 rs11155641 chr6:149648595 G/A cg11245181 chr6:149772854 ZC3H12D 0.28 5.95 0.31 6.88e-9 Dupuytren's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05972000 chr8:67525501 MYBL1 -0.4 -6.1 -0.32 2.99e-9 Electrocardiographic conduction measures; LUSC cis rs9549260 0.564 rs4941990 chr13:41299857 A/C cg21288729 chr13:41239152 FOXO1 0.53 7.95 0.4 3e-14 Red blood cell count; LUSC cis rs12760731 0.720 rs722321 chr1:178420220 C/T cg00404053 chr1:178313656 RASAL2 0.62 6.56 0.34 2.09e-10 Obesity-related traits; LUSC cis rs7582180 0.629 rs11123827 chr2:100951248 C/G cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg18876405 chr7:65276391 NA 0.77 13.41 0.59 4.13e-33 Calcium levels; LUSC cis rs17401966 0.540 rs4846199 chr1:10283961 A/G cg17425144 chr1:10567563 PEX14 -0.33 -5.78 -0.3 1.69e-8 Hepatocellular carcinoma; LUSC cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg05347473 chr6:146136440 FBXO30 -0.59 -10.56 -0.5 1.11e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs1371867 0.846 rs1660317 chr8:101333252 G/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs6138458 1.000 rs227651 chr20:24929834 A/G cg06937882 chr20:24974362 C20orf3 -0.44 -7.49 -0.38 6.07e-13 Blood protein levels; LUSC cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg05985134 chr18:33552581 C18orf21 -0.57 -7.83 -0.39 6.73e-14 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs67460515 0.892 rs73026974 chr3:160963231 A/C cg03342759 chr3:160939853 NMD3 -0.55 -8.04 -0.4 1.62e-14 Parkinson's disease; LUSC cis rs2439831 0.850 rs3825783 chr15:44102309 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.54 0.42 4.83e-16 Lung cancer in ever smokers; LUSC cis rs13253111 0.624 rs7012030 chr8:28096346 C/T cg26534493 chr8:28060551 NA 0.38 6.91 0.35 2.47e-11 Childhood body mass index; LUSC trans rs10506458 0.915 rs1009540 chr12:63414872 C/A cg22491629 chr6:157744540 C6orf35 -0.9 -10.97 -0.51 4.22e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg09467607 chr2:36825704 FEZ2 -0.52 -10.95 -0.51 4.95e-24 Height; LUSC trans rs60843830 1.000 rs4497901 chr2:239969 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 10.67 0.5 4.48e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9436747 0.714 rs1186403 chr1:66000533 C/T cg14976592 chr1:65886160 LEPROT;LEPR -0.44 -5.94 -0.31 7.35e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs11051970 0.879 rs1500874 chr12:32589407 G/A cg02745156 chr12:32552066 NA 0.43 7.29 0.37 2.29e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg19774624 chr17:42201019 HDAC5 -0.66 -10.41 -0.5 3.5e-22 Total body bone mineral density; LUSC cis rs909685 1.000 rs2069235 chr22:39747780 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.48 6.89 0.35 2.75e-11 Rheumatoid arthritis; LUSC cis rs16854884 1.000 rs11924473 chr3:143787075 C/G cg06585982 chr3:143692056 C3orf58 0.47 6.58 0.34 1.85e-10 Economic and political preferences (feminism/equality); LUSC cis rs1506636 1.000 rs2299984 chr7:123356921 G/T cg03229431 chr7:123269106 ASB15 0.64 10.49 0.5 1.97e-22 Plateletcrit;Platelet count; LUSC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs11148252 0.669 rs61958050 chr13:52994427 A/C cg02158880 chr13:53174818 NA 0.4 5.92 0.31 7.86e-9 Lewy body disease; LUSC cis rs778371 0.723 rs6739794 chr2:233576165 G/A cg08000102 chr2:233561755 GIGYF2 0.81 14.11 0.61 8.92e-36 Schizophrenia; LUSC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg26314531 chr2:26401878 FAM59B -0.7 -9.6 -0.47 1.92e-19 Gut microbiome composition (summer); LUSC cis rs34779708 0.931 rs4934702 chr10:35323074 T/C cg03585969 chr10:35415529 CREM 0.6 8.74 0.43 1.12e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1448094 0.813 rs6539942 chr12:86452969 T/C cg02569458 chr12:86230093 RASSF9 -0.36 -5.87 -0.31 1.07e-8 Major depressive disorder; LUSC cis rs10416265 0.528 rs7249097 chr19:33589144 T/C cg03563238 chr19:33554763 RHPN2 -0.37 -6.34 -0.33 7.24e-10 Bone properties (heel); LUSC cis rs7043114 0.525 rs8067 chr9:95218829 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.65 -0.34 1.18e-10 Height; LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.2 0.37 3.93e-12 Platelet count; LUSC cis rs7215564 0.818 rs34754307 chr17:78652758 C/G cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03264133 chr6:25882463 NA -0.58 -10.03 -0.48 6.94e-21 Blood metabolite levels; LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg16405210 chr4:1374714 KIAA1530 -0.56 -8.61 -0.43 3.02e-16 Obesity-related traits; LUSC cis rs860295 0.812 rs12407800 chr1:155760742 A/C cg08949192 chr1:155289623 RUSC1;FDPS -0.35 -5.72 -0.3 2.41e-8 Body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09672082 chr5:271577 PDCD6 -0.51 -6.02 -0.31 4.47e-9 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.529 rs6060291 chr20:30198043 T/G cg18721089 chr20:30220636 NA -0.37 -5.82 -0.3 1.41e-8 Mean corpuscular hemoglobin; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg18538332 chr22:24372958 LOC391322 -0.47 -8.31 -0.41 2.41e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9640161 0.830 rs11972067 chr7:150071605 G/A cg10018233 chr7:150070692 REPIN1 0.45 9.06 0.44 1.13e-17 Blood protein levels;Circulating chemerin levels; LUSC cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.68 -0.5 4.17e-23 Monocyte percentage of white cells; LUSC cis rs34779708 0.966 rs35777088 chr10:35409048 T/C cg04310649 chr10:35416472 CREM -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13223928 0.658 rs67519056 chr7:3157176 G/C cg19214707 chr7:3157722 NA -0.54 -10.82 -0.51 1.37e-23 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2742417 1.000 rs938362 chr3:45746365 T/C cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.48e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs2652822 1.000 rs2652822 chr15:63422772 C/T cg02713581 chr15:63449717 RPS27L -0.38 -6.11 -0.32 2.74e-9 Metabolic traits; LUSC cis rs1018836 0.923 rs9694450 chr8:91618292 G/A cg16814680 chr8:91681699 NA -0.77 -12.92 -0.58 3.06e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs11935423 0.778 rs2866164 chr4:100490943 C/G cg02164153 chr5:172068145 NEURL1B -0.47 -6.1 -0.32 3e-9 Gut microbiome composition (summer); LUSC cis rs1371867 0.810 rs2919470 chr8:101233301 C/A cg06002616 chr8:101225028 SPAG1 0.46 7.56 0.38 4.05e-13 Atrioventricular conduction; LUSC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg18190219 chr22:46762943 CELSR1 -0.42 -5.69 -0.3 2.78e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 10.83 0.51 1.23e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6977660 0.619 rs10223937 chr7:19787697 C/T cg05791153 chr7:19748676 TWISTNB 0.67 7.27 0.37 2.65e-12 Thyroid stimulating hormone; LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg04944784 chr2:26401820 FAM59B 0.7 8.98 0.44 2.07e-17 Gut microbiome composition (summer); LUSC cis rs4619890 0.528 rs62289337 chr4:7877939 G/A cg24250820 chr4:7887609 AFAP1 0.36 6.15 0.32 2.17e-9 Glaucoma (primary open-angle); LUSC cis rs7043114 0.525 rs4744134 chr9:95246833 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.35 6.25 0.32 1.24e-9 Height; LUSC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.4 0.38 1.13e-12 Schizophrenia; LUSC cis rs71636778 0.543 rs36109400 chr1:27247822 G/A cg12203394 chr1:27248618 NUDC 0.53 5.65 0.3 3.47e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg15445000 chr17:37608096 MED1 0.39 6.78 0.35 5.4e-11 Glomerular filtration rate (creatinine); LUSC cis rs6951245 0.678 rs4724725 chr7:1214751 G/A cg18402987 chr7:1209562 NA 0.74 8.02 0.4 1.81e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg18681998 chr4:17616180 MED28 0.9 17.51 0.69 3.65e-49 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6556937 0.562 rs6897588 chr5:96003149 T/G cg07690455 chr5:95997198 CAST 0.47 6.52 0.34 2.54e-10 Blood protein levels; LUSC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg18131467 chr2:239335373 ASB1 1.05 24.68 0.8 2.76e-77 Multiple system atrophy; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11117577 chr8:125551212 TATDN1;NDUFB9 -0.53 -7.04 -0.36 1.07e-11 Hepatitis; LUSC cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg03264133 chr6:25882463 NA -0.34 -5.77 -0.3 1.84e-8 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg04455712 chr21:45112962 RRP1B 0.46 8.64 0.43 2.31e-16 Mean corpuscular volume; LUSC cis rs1965732 1.000 rs1965732 chr2:3709108 A/G cg00999904 chr2:3704751 ALLC -0.33 -6.0 -0.31 5.01e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg19196401 chr6:110721138 DDO 0.41 7.69 0.39 1.61e-13 Platelet distribution width; LUSC cis rs7296418 0.961 rs11608811 chr12:123529056 A/G cg00376283 chr12:123451042 ABCB9 0.83 13.16 0.58 3.69e-32 Platelet count; LUSC cis rs1018836 0.632 rs6988302 chr8:91477660 C/T cg16814680 chr8:91681699 NA -0.66 -9.81 -0.47 3.97e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs17125944 0.505 rs28568967 chr14:53223060 A/G cg00686598 chr14:53173677 PSMC6 1.15 10.47 0.5 2.35e-22 Alzheimer's disease (late onset); LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg10411590 chr13:21900810 NA 0.3 6.04 0.31 4.04e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs2289328 0.882 rs7164606 chr15:40645133 G/A cg13931752 chr15:40660718 DISP2 0.47 6.36 0.33 6.61e-10 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs34779708 0.931 rs72789690 chr10:35382817 T/C cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg17211192 chr8:82754475 SNX16 -0.82 -11.26 -0.52 3.87e-25 Diastolic blood pressure; LUSC cis rs977987 0.966 rs62060551 chr16:75502312 A/C cg03315344 chr16:75512273 CHST6 0.55 10.7 0.51 3.58e-23 Dupuytren's disease; LUSC cis rs9314323 0.862 rs7813520 chr8:26263260 C/T cg13160058 chr8:26243215 BNIP3L -0.41 -7.44 -0.38 8.49e-13 Red cell distribution width; LUSC cis rs699 0.556 rs2478525 chr1:230865350 C/G cg07502417 chr1:230849801 AGT 0.26 6.41 0.33 5.03e-10 Coronary artery disease; LUSC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.31 6.08 0.32 3.33e-9 Schizophrenia; LUSC cis rs9814567 1.000 rs13322305 chr3:134310791 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2230307 0.572 rs17122001 chr1:100628311 A/T cg24955406 chr1:100503596 HIAT1 0.6 6.44 0.33 4.14e-10 Carotid intima media thickness; LUSC cis rs34779708 0.931 rs34375045 chr10:35362356 A/C cg03585969 chr10:35415529 CREM 0.58 8.39 0.42 1.34e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs73198271 0.653 rs10087633 chr8:8660444 A/G cg01851573 chr8:8652454 MFHAS1 0.48 8.13 0.41 8.32e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg13395646 chr4:1353034 KIAA1530 0.49 6.93 0.35 2.16e-11 Obesity-related traits; LUSC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg06238570 chr21:40685208 BRWD1 -0.62 -10.38 -0.49 4.53e-22 Cognitive function; LUSC cis rs6736093 0.966 rs74182850 chr2:112681337 C/T cg12686935 chr2:112915763 FBLN7 -0.37 -5.9 -0.31 8.73e-9 Coronary artery disease; LUSC cis rs3820068 0.603 rs17448778 chr1:15985306 A/G cg13390004 chr1:15929781 NA 0.41 6.88 0.35 3.03e-11 Systolic blood pressure; LUSC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.64 8.0 0.4 2.02e-14 Lung function (FEV1/FVC); LUSC cis rs9467773 0.967 rs9295694 chr6:26512994 A/T cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.12e-18 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg15145296 chr3:125709740 NA -0.56 -6.24 -0.32 1.29e-9 Blood pressure (smoking interaction); LUSC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg15147215 chr3:52552868 STAB1 -0.32 -6.33 -0.33 7.69e-10 Electroencephalogram traits; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg27094323 chr7:1216898 NA -0.45 -7.62 -0.38 2.7e-13 Longevity;Endometriosis; LUSC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22455342 chr2:225449267 CUL3 0.78 10.81 0.51 1.43e-23 IgE levels in asthmatics (D.p. specific); LUSC cis rs7592578 0.882 rs58568707 chr2:191468987 G/A cg10560079 chr2:191398806 TMEM194B -0.68 -8.64 -0.43 2.45e-16 Diastolic blood pressure; LUSC cis rs2295359 0.892 rs6688383 chr1:67655954 C/T cg03340356 chr1:67600835 NA -0.39 -5.83 -0.3 1.27e-8 Psoriasis; LUSC cis rs514406 0.536 rs878957 chr1:53197559 C/T cg16325326 chr1:53192061 ZYG11B -0.91 -17.43 -0.69 7.38e-49 Monocyte count; LUSC cis rs2795502 1.000 rs2473119 chr10:43339038 A/T cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg25036284 chr2:26402008 FAM59B -0.71 -9.77 -0.47 5.35e-20 Gut microbiome composition (summer); LUSC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 11.23 0.52 4.73e-25 Platelet count; LUSC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.3 0.33 9.26e-10 Schizophrenia; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg13560548 chr3:10150139 C3orf24 0.53 7.2 0.37 3.99e-12 Alzheimer's disease; LUSC cis rs12220238 1.000 rs7083534 chr10:75955672 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.12e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg06550200 chr5:1325588 CLPTM1L -0.65 -10.94 -0.51 5.34e-24 Lung cancer; LUSC cis rs68170813 0.559 rs12536603 chr7:107002573 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.56 -0.46 2.74e-19 Coronary artery disease; LUSC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 17.1 0.68 1.62e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.07 -0.32 3.43e-9 Neutrophil percentage of white cells; LUSC cis rs1007190 0.881 rs71373521 chr17:42949442 C/T cg15406952 chr17:42872593 NA 0.55 5.67 0.3 3.05e-8 DNA methylation (variation); LUSC cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9467711 0.591 rs35169013 chr6:25918027 A/C cg08501292 chr6:25962987 TRIM38 0.66 5.69 0.3 2.78e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs8038465 0.638 rs7495543 chr15:73955133 G/C cg15420318 chr15:73925796 NPTN 0.61 10.61 0.5 7.53e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs11971779 0.616 rs11771715 chr7:139027496 T/C cg07862535 chr7:139043722 LUC7L2 0.53 6.58 0.34 1.84e-10 Diisocyanate-induced asthma; LUSC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg26384229 chr12:38710491 ALG10B 0.88 15.08 0.64 1.52e-39 Morning vs. evening chronotype; LUSC cis rs2859741 0.546 rs2102087 chr1:37482849 G/A cg09363841 chr1:37513479 NA -0.4 -7.69 -0.39 1.69e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs9486715 0.838 rs9320127 chr6:96865358 G/A cg06623918 chr6:96969491 KIAA0776 0.93 17.66 0.69 8.89e-50 Headache; LUSC cis rs7973719 1.000 rs12828040 chr12:7326541 T/C cg07052231 chr12:7363540 PEX5 0.53 9.17 0.45 4.89e-18 IgG glycosylation; LUSC trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg26647111 chr11:31128758 NA -0.41 -6.0 -0.31 5.27e-9 Red blood cell count; LUSC cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg03213289 chr20:61660250 NA 0.58 9.65 0.47 1.38e-19 Prostate cancer (SNP x SNP interaction); LUSC cis rs34779708 0.931 rs9663401 chr10:35278849 G/T cg03585969 chr10:35415529 CREM 0.65 9.25 0.45 2.78e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg21535247 chr6:8435926 SLC35B3 -0.61 -9.47 -0.46 5.21e-19 Motion sickness; LUSC cis rs8060686 0.565 rs55857142 chr16:68236741 A/T cg27539214 chr16:67997921 SLC12A4 -0.6 -7.42 -0.38 9.57e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg13010199 chr12:38710504 ALG10B 0.67 10.22 0.49 1.58e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs4363385 0.747 rs1611760 chr1:152957573 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.78 -0.39 9.11e-14 Inflammatory skin disease; LUSC cis rs2835872 0.931 rs10483038 chr21:39024771 T/C cg20424643 chr21:39039972 KCNJ6 0.48 7.11 0.36 7.14e-12 Electroencephalographic traits in alcoholism; LUSC cis rs240764 0.853 rs11155496 chr6:100988939 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.08 -0.32 3.38e-9 Neuroticism; LUSC cis rs6500602 0.647 rs4786519 chr16:4584406 C/T cg08645402 chr16:4508243 NA 0.5 8.41 0.42 1.24e-15 Schizophrenia; LUSC cis rs10751667 0.600 rs7950955 chr11:1011490 G/A cg06064525 chr11:970664 AP2A2 -0.29 -5.68 -0.3 2.94e-8 Alzheimer's disease (late onset); LUSC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg03676636 chr4:99064102 C4orf37 0.37 8.04 0.4 1.58e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg08847533 chr14:75593920 NEK9 0.84 15.45 0.65 5.43e-41 Height; LUSC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg21573476 chr21:45109991 RRP1B -0.41 -6.66 -0.34 1.11e-10 Mean corpuscular volume; LUSC cis rs1577917 1.000 rs2816821 chr6:86657084 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.66e-9 Response to antipsychotic treatment; LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg08470875 chr2:26401718 FAM59B -0.65 -8.86 -0.44 4.68e-17 Gut microbiome composition (summer); LUSC cis rs10782582 0.609 rs5745347 chr1:76274520 C/T cg10523679 chr1:76189770 ACADM 0.47 6.86 0.35 3.43e-11 Daytime sleep phenotypes; LUSC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg07636037 chr3:49044803 WDR6 1.02 17.67 0.7 8.45e-50 Parkinson's disease; LUSC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg15744005 chr10:104629667 AS3MT -0.29 -6.22 -0.32 1.46e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11122272 0.735 rs10489611 chr1:231517854 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs12410462 0.581 rs77430808 chr1:227540880 C/T cg04117972 chr1:227635322 NA 0.6 6.82 0.35 4.41e-11 Major depressive disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01249180 chr5:95997867 CAST 0.42 6.31 0.33 8.89e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03532510 chr1:224544720 CNIH4 -0.43 -6.4 -0.33 5.26e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4595586 0.545 rs1588970 chr12:39403122 C/A cg26384229 chr12:38710491 ALG10B 0.5 7.15 0.36 5.4e-12 Morning vs. evening chronotype; LUSC cis rs6430585 0.646 rs12476116 chr2:136497199 A/G cg07169764 chr2:136633963 MCM6 1.16 16.34 0.67 1.58e-44 Corneal structure; LUSC cis rs1997103 1.000 rs2331067 chr7:55408232 A/T cg17469321 chr7:55412551 NA 0.65 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg00677455 chr12:58241039 CTDSP2 0.54 6.92 0.35 2.26e-11 Multiple sclerosis; LUSC trans rs3857536 0.505 rs208459 chr6:66911055 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.75 -10.17 -0.49 2.38e-21 Blood trace element (Cu levels); LUSC cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg08975724 chr8:8085496 FLJ10661 -0.4 -5.79 -0.3 1.66e-8 Systolic blood pressure; LUSC cis rs713587 0.713 rs12466350 chr2:25239969 A/G cg15423357 chr2:25149977 NA 0.37 7.19 0.37 4.29e-12 Body mass index in non-asthmatics; LUSC cis rs7428496 0.510 rs13072346 chr3:142300002 G/A cg16271453 chr3:142027066 XRN1 -0.48 -8.13 -0.41 8.33e-15 Mean corpuscular hemoglobin; LUSC cis rs10746514 1.000 rs61835640 chr1:232245014 G/A cg09506761 chr1:232265262 NA 0.46 7.35 0.37 1.57e-12 Response to statin therapy; LUSC trans rs724744 0.742 rs1205933 chr6:22358361 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs9815354 0.516 rs115135603 chr3:42031622 T/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs11626933 1.000 rs7149083 chr14:90754006 G/A cg14092571 chr14:90743983 NA -0.88 -18.4 -0.71 1.03e-52 Gut microbiota (bacterial taxa); LUSC cis rs35883536 0.566 rs10783141 chr1:101043897 G/A cg06223162 chr1:101003688 GPR88 -0.48 -9.12 -0.45 7.32e-18 Monocyte count; LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02475777 chr4:1388615 CRIPAK -0.6 -8.94 -0.44 2.65e-17 Longevity; LUSC cis rs6121246 0.738 rs2376996 chr20:30316667 T/A cg13852791 chr20:30311386 BCL2L1 0.9 12.15 0.55 2.14e-28 Mean corpuscular hemoglobin; LUSC cis rs250677 0.522 rs10045726 chr5:148352990 C/T cg18129178 chr5:148520854 ABLIM3 0.54 7.6 0.38 2.97e-13 Breast cancer; LUSC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg24250549 chr1:154909240 PMVK 0.56 8.7 0.43 1.57e-16 Prostate cancer; LUSC cis rs16854884 0.657 rs1867609 chr3:143752916 A/G cg06585982 chr3:143692056 C3orf58 0.5 7.91 0.4 3.89e-14 Economic and political preferences (feminism/equality); LUSC cis rs9814567 0.896 rs6763188 chr3:134349995 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 0.33 6.07 0.32 3.46e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs877282 0.891 rs11253393 chr10:788824 G/T cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs4654899 0.758 rs6697284 chr1:21295599 G/A cg01072550 chr1:21505969 NA -0.53 -8.08 -0.4 1.23e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg05623727 chr3:50126028 RBM5 -0.32 -5.94 -0.31 7.12e-9 Menarche (age at onset); LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg18758796 chr5:131593413 PDLIM4 0.44 7.23 0.37 3.26e-12 Breast cancer; LUSC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg15445000 chr17:37608096 MED1 0.39 6.64 0.34 1.3e-10 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs477692 0.629 rs945231 chr10:131294827 A/G cg05714579 chr10:131428358 MGMT 0.4 5.64 0.3 3.54e-8 Response to temozolomide; LUSC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs16867321 0.950 rs4667228 chr2:181498824 T/A cg23363182 chr2:181467187 NA -0.44 -5.74 -0.3 2.16e-8 Obesity; LUSC cis rs763121 0.853 rs2179142 chr22:39037954 G/A cg06022373 chr22:39101656 GTPBP1 0.82 13.25 0.59 1.72e-32 Menopause (age at onset); LUSC cis rs6484504 0.532 rs7121949 chr11:31288160 G/T cg26647111 chr11:31128758 NA -0.41 -5.86 -0.31 1.12e-8 Red blood cell count; LUSC cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.13 0.41 8.56e-15 Axial length; LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg08470875 chr2:26401718 FAM59B -0.7 -9.13 -0.45 6.74e-18 Gut microbiome composition (summer); LUSC trans rs6952808 1.000 rs6953693 chr7:1886388 C/G cg24247370 chr13:99142703 STK24 -0.34 -6.3 -0.33 9.6e-10 Bipolar disorder and schizophrenia; LUSC cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg22590775 chr19:49891494 CCDC155 0.57 8.28 0.41 3.06e-15 Multiple sclerosis; LUSC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg14773178 chr5:1868261 NA 0.31 5.8 0.3 1.5e-8 Cardiovascular disease risk factors; LUSC cis rs7590720 0.819 rs1344694 chr2:216893637 T/G cg12620499 chr2:216877984 MREG 0.92 15.42 0.64 6.74e-41 Alcohol dependence; LUSC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg24675056 chr1:15929824 NA 0.48 8.33 0.41 2.17e-15 Systolic blood pressure; LUSC cis rs10875746 0.951 rs58865997 chr12:48566873 G/A cg13454099 chr12:49076203 C12orf41 -0.51 -5.95 -0.31 6.91e-9 Longevity (90 years and older); LUSC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg07507251 chr3:52567010 NT5DC2 -0.42 -7.58 -0.38 3.46e-13 Bipolar disorder; LUSC cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg02527881 chr3:46936655 PTH1R -0.39 -6.85 -0.35 3.66e-11 Colorectal cancer; LUSC cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg18904891 chr8:8559673 CLDN23 0.59 8.1 0.41 1.03e-14 Obesity-related traits; LUSC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg19539972 chr4:7069911 GRPEL1 0.71 8.67 0.43 1.87e-16 Monocyte percentage of white cells; LUSC trans rs2204008 0.575 rs10444564 chr12:38043782 T/C cg06521331 chr12:34319734 NA -0.39 -5.95 -0.31 6.77e-9 Bladder cancer; LUSC cis rs7582180 0.817 rs7559464 chr2:100906323 A/G cg08017756 chr2:100939284 LONRF2 -0.35 -5.82 -0.3 1.39e-8 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg00409905 chr10:38381863 ZNF37A -0.36 -6.26 -0.32 1.2e-9 Extrinsic epigenetic age acceleration; LUSC cis rs3770081 1.000 rs58365138 chr2:86213105 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.04 -6.7 -0.34 8.99e-11 Facial emotion recognition (sad faces); LUSC trans rs877282 0.755 rs11253399 chr10:790030 T/A cg13042288 chr15:90349979 ANPEP -0.41 -6.27 -0.32 1.13e-9 Uric acid levels; LUSC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg04352962 chr1:209979756 IRF6 0.54 7.16 0.36 5.32e-12 Cleft lip with or without cleft palate; LUSC cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg23158103 chr7:148848205 ZNF398 -0.42 -6.56 -0.34 2.11e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.31e-41 Bladder cancer; LUSC cis rs2011503 0.825 rs4808932 chr19:19358819 C/T cg11584989 chr19:19387371 SF4 0.62 7.39 0.38 1.16e-12 Bipolar disorder; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg05552183 chr6:42928497 GNMT 0.54 9.23 0.45 3.21e-18 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg17330251 chr7:94953956 PON1 -0.37 -5.86 -0.31 1.1e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs4920343 0.890 rs4920531 chr1:19095746 A/G cg26220594 chr1:19110978 NA -0.34 -5.71 -0.3 2.54e-8 Knee osteoarthritis; LUSC cis rs997295 0.554 rs28568344 chr15:68096527 A/G cg08079166 chr15:68083412 MAP2K5 0.37 7.78 0.39 9.09e-14 Motion sickness; LUSC cis rs727505 0.954 rs67146030 chr7:124561790 T/G cg23710748 chr7:124431027 NA -0.42 -7.42 -0.38 9.76e-13 Lewy body disease; LUSC cis rs6700896 0.897 rs7518710 chr1:66168238 G/A cg04111102 chr1:66153794 NA -0.33 -6.97 -0.36 1.68e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg11062466 chr8:58055876 NA 0.65 8.96 0.44 2.3e-17 Developmental language disorder (linguistic errors); LUSC cis rs354225 0.544 rs13399656 chr2:54802696 T/G cg01766943 chr2:54829624 SPTBN1 0.49 7.84 0.39 6.04e-14 Schizophrenia; LUSC cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg23158103 chr7:148848205 ZNF398 -0.49 -7.87 -0.4 4.86e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2617583 0.967 rs2550947 chr5:1450506 T/C cg07148919 chr5:1466943 LPCAT1 0.39 5.92 0.31 7.94e-9 Breast cancer; LUSC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg05347473 chr6:146136440 FBXO30 0.53 9.04 0.44 1.3e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs1790761 0.505 rs7941648 chr11:67347595 C/T cg24690094 chr11:67383802 NA -0.3 -5.75 -0.3 1.98e-8 Mean corpuscular volume; LUSC cis rs3820928 1.000 rs10167422 chr2:227777554 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.8e-14 Pulmonary function; LUSC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg07937631 chr13:79184529 NA -0.42 -6.85 -0.35 3.5e-11 Large artery stroke; LUSC cis rs6977940 0.818 rs11769302 chr7:2898839 C/T cg19731401 chr7:2775893 GNA12 0.66 7.95 0.4 3e-14 White matter integrity; LUSC cis rs9388451 0.505 rs6920965 chr6:126179111 G/A cg05901451 chr6:126070800 HEY2 -0.64 -10.04 -0.48 6.54e-21 Brugada syndrome; LUSC cis rs2230307 0.536 rs581097 chr1:100515920 C/T cg24955406 chr1:100503596 HIAT1 0.57 6.15 0.32 2.23e-9 Carotid intima media thickness; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg06263672 chr7:65235340 NA 0.43 6.17 0.32 1.97e-9 Calcium levels; LUSC cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg16423285 chr20:60520624 NA 0.94 13.06 0.58 8.84e-32 Obesity-related traits; LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs1564271 0.553 rs9334138 chr10:26978929 G/A cg13837822 chr10:26931731 LOC731789 0.45 9.73 0.47 7.27e-20 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs11625487 1.000 rs11625487 chr14:77961609 G/C cg20045696 chr14:77926864 AHSA1 0.45 6.03 0.31 4.39e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs7827545 1.000 rs1372659 chr8:135566779 T/A cg17885191 chr8:135476712 NA 0.57 8.5 0.42 6.26e-16 Hypertension (SNP x SNP interaction); LUSC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs1728785 0.818 rs1728769 chr16:68564186 C/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg24549020 chr5:56110836 MAP3K1 0.49 5.7 0.3 2.69e-8 Initial pursuit acceleration; LUSC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg02931644 chr1:25747376 RHCE 0.32 5.79 0.3 1.59e-8 Erythrocyte sedimentation rate; LUSC cis rs926938 0.505 rs360593 chr1:115472265 T/G cg12756093 chr1:115239321 AMPD1 0.46 7.04 0.36 1.13e-11 Autism; LUSC cis rs2425143 1.000 rs4504072 chr20:34448773 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.98 -0.31 5.8e-9 Blood protein levels; LUSC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg20135002 chr11:47629003 NA -0.52 -8.29 -0.41 2.81e-15 Subjective well-being; LUSC cis rs6519955 0.796 rs4072455 chr22:46422938 T/C cg05468064 chr22:46423449 NA 0.43 6.61 0.34 1.5e-10 Dupuytren's disease; LUSC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg11764359 chr7:65958608 NA -0.7 -10.65 -0.5 5.44e-23 Aortic root size; LUSC trans rs6076960 0.811 rs6053960 chr20:6176778 T/C cg17788362 chr6:86352627 SYNCRIP 0.4 5.98 0.31 5.81e-9 Smooth-surface caries; LUSC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg04369109 chr6:150039330 LATS1 -0.6 -8.83 -0.43 6.2e-17 Lung cancer; LUSC cis rs62400317 0.859 rs11964844 chr6:45258823 T/A cg18551225 chr6:44695536 NA -0.42 -7.05 -0.36 1.03e-11 Total body bone mineral density; LUSC cis rs2303282 0.865 rs446167 chr16:56559465 G/A cg00500540 chr16:56394104 NA 0.43 6.96 0.36 1.8e-11 Breast cancer; LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg23711669 chr6:146136114 FBXO30 0.87 15.93 0.66 6.54e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20546810 chr20:2489835 ZNF343 0.8 6.17 0.32 1.97e-9 Cognitive performance; LUSC trans rs7829975 0.514 rs2920991 chr8:8259117 T/A cg02679955 chr17:73521473 LLGL2 0.4 5.94 0.31 7.01e-9 Mood instability; LUSC cis rs4851254 0.660 rs4851244 chr2:100671449 C/T cg07810366 chr2:100720526 AFF3 0.43 5.91 0.31 8.4e-9 Intelligence (multi-trait analysis); LUSC cis rs10203711 1.000 rs6713610 chr2:239566874 C/A cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7100689 0.753 rs1572816 chr10:82137600 A/G cg00277334 chr10:82204260 NA -0.5 -6.86 -0.35 3.37e-11 Post bronchodilator FEV1; LUSC trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs11039798 1.000 rs9667626 chr11:48485877 T/C cg15704280 chr7:45808275 SEPT13 0.71 6.62 0.34 1.46e-10 Axial length; LUSC cis rs9300255 0.602 rs1727315 chr12:123638930 A/G cg13010344 chr12:123464640 ARL6IP4 0.47 6.43 0.33 4.31e-10 Neutrophil percentage of white cells; LUSC cis rs10911232 0.524 rs10737238 chr1:183025303 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.16 0.52 8.54e-25 Hypertriglyceridemia; LUSC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg09034736 chr1:150693464 HORMAD1 0.48 6.91 0.35 2.44e-11 Tonsillectomy; LUSC cis rs617219 0.889 rs10069036 chr5:78469223 A/T cg24856658 chr5:78533917 JMY -0.3 -5.75 -0.3 1.98e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9814567 1.000 rs13081177 chr3:134289860 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.86 14.25 0.61 2.62e-36 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg15605315 chr1:45957053 TESK2 0.5 8.48 0.42 7.48e-16 High light scatter reticulocyte count; LUSC cis rs7937682 0.587 rs571594 chr11:111359334 A/G cg09085632 chr11:111637200 PPP2R1B 0.45 6.34 0.33 7.65e-10 Primary sclerosing cholangitis; LUSC cis rs2274273 0.624 rs11848575 chr14:55755788 A/G cg04306507 chr14:55594613 LGALS3 0.48 9.85 0.47 2.9e-20 Protein biomarker; LUSC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg21285383 chr16:89894308 SPIRE2 0.34 7.09 0.36 7.96e-12 Vitiligo; LUSC cis rs8062405 1.000 rs4788101 chr16:28867804 C/T cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9400467 0.528 rs465795 chr6:111676443 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC trans rs8072100 1.000 rs11650372 chr17:45721795 G/A cg04995722 chr7:26192034 NFE2L3 -0.36 -5.96 -0.31 6.23e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg26335602 chr6:28129616 ZNF389 0.45 6.13 0.32 2.43e-9 Depression; LUSC cis rs1348850 0.668 rs12618542 chr2:178494520 A/G cg23306229 chr2:178417860 TTC30B 0.51 5.66 0.3 3.3e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg26384229 chr12:38710491 ALG10B 0.87 14.82 0.63 1.59e-38 Bladder cancer; LUSC cis rs4888262 0.508 rs4544266 chr16:74660993 C/A cg01733217 chr16:74700730 RFWD3 0.73 11.71 0.54 8.82e-27 Testicular germ cell tumor; LUSC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.98 -0.36 1.63e-11 Colorectal cancer; LUSC cis rs7223966 0.921 rs67018565 chr17:61928055 C/A cg05941027 chr17:61774174 LIMD2 0.22 5.79 0.3 1.64e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg05585544 chr11:47624801 NA -0.42 -7.14 -0.36 5.74e-12 Subjective well-being; LUSC cis rs9788721 0.836 rs17483721 chr15:78733731 C/T cg18825076 chr15:78729989 IREB2 0.56 9.2 0.45 3.91e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2282300 0.696 rs12578061 chr11:30249365 T/A cg06241208 chr11:30344200 C11orf46 -0.44 -5.65 -0.3 3.52e-8 Morning vs. evening chronotype; LUSC cis rs10754283 0.967 rs4658130 chr1:90113447 G/C cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs11126435 0.641 rs6709863 chr2:74746080 C/T cg04255230 chr2:74727010 LBX2 0.43 6.88 0.35 2.88e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs8017423 0.935 rs11621820 chr14:90727154 C/T cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg26384229 chr12:38710491 ALG10B 0.92 15.75 0.65 3.5e-42 Bladder cancer; LUSC trans rs7726839 0.507 rs56282020 chr5:596701 T/C cg11887960 chr12:57824829 NA 0.54 6.8 0.35 4.89e-11 Obesity-related traits; LUSC cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg14689365 chr7:158441557 NCAPG2 0.53 7.55 0.38 4.24e-13 Height; LUSC cis rs72781680 1.000 rs72781648 chr2:24210333 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs17253792 0.731 rs8008528 chr14:56062052 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs7587476 0.601 rs13021937 chr2:215673937 C/T cg04004882 chr2:215674386 BARD1 -0.53 -7.37 -0.37 1.34e-12 Neuroblastoma; LUSC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg16325326 chr1:53192061 ZYG11B -0.98 -20.0 -0.74 4.61e-59 Monocyte count; LUSC cis rs7246967 0.604 rs8107322 chr19:22897432 A/C cg23217946 chr19:22817039 ZNF492 0.41 5.68 0.3 2.93e-8 Bronchopulmonary dysplasia; LUSC cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.34 -0.42 2.01e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 5.89 0.31 9.39e-9 Personality dimensions; LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg03579872 chr1:53393473 SCP2 0.39 5.75 0.3 2.01e-8 Monocyte count; LUSC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg06238570 chr21:40685208 BRWD1 0.52 7.96 0.4 2.75e-14 Cognitive function; LUSC cis rs8072100 0.666 rs6503804 chr17:45772447 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.38 -6.33 -0.33 7.89e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4595586 0.525 rs12825567 chr12:39386621 C/T cg13010199 chr12:38710504 ALG10B 0.4 5.78 0.3 1.69e-8 Morning vs. evening chronotype; LUSC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.84 0.35 3.83e-11 Intelligence (multi-trait analysis); LUSC cis rs1215050 0.740 rs783932 chr4:98973936 C/G cg05340658 chr4:99064831 C4orf37 -0.47 -7.45 -0.38 8.22e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9467773 0.572 rs2076029 chr6:26390830 T/C cg09904177 chr6:26538194 HMGN4 -0.52 -7.75 -0.39 1.1e-13 Intelligence (multi-trait analysis); LUSC cis rs8077577 0.895 rs62072468 chr17:18118179 A/G cg16794390 chr17:18148240 FLII 0.41 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg04450456 chr4:17643702 FAM184B 0.35 5.81 0.3 1.43e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8062405 0.754 rs3859172 chr16:28566158 G/T cg16576597 chr16:28551801 NUPR1 0.28 5.76 0.3 1.92e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg00071950 chr4:10020882 SLC2A9 0.58 9.7 0.47 9.12e-20 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1395 0.744 rs11126932 chr2:27476282 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.57 0.38 3.75e-13 Blood metabolite levels; LUSC cis rs134594 0.961 rs134599 chr22:29472863 G/A cg03665785 chr22:29458676 C22orf31 0.28 5.75 0.3 1.96e-8 Birth weight; LUSC cis rs7100689 0.577 rs873395 chr10:82037215 C/T cg00277334 chr10:82204260 NA 0.48 6.5 0.33 2.99e-10 Post bronchodilator FEV1; LUSC cis rs11098499 0.909 rs7681978 chr4:120383775 T/C cg09307838 chr4:120376055 NA 0.77 11.09 0.52 1.49e-24 Corneal astigmatism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23071962 chr2:12856964 TRIB2 -0.49 -6.09 -0.32 3.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs11077815 0.815 rs7223304 chr17:74447090 C/T cg06840243 chr17:74442338 UBE2O -0.35 -6.23 -0.32 1.42e-9 Lymphocyte counts; LUSC cis rs595982 0.527 rs12151238 chr19:49368613 T/C cg15549821 chr19:49342101 PLEKHA4 -0.59 -8.04 -0.4 1.6e-14 Red cell distribution width; LUSC cis rs11105298 0.891 rs11105318 chr12:89926658 C/T cg00757033 chr12:89920650 WDR51B 0.52 8.87 0.44 4.45e-17 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg22638593 chr5:131593259 PDLIM4 0.42 6.24 0.32 1.31e-9 Breast cancer; LUSC cis rs317689 0.690 rs10878947 chr12:69642683 A/T cg11871910 chr12:69753446 YEATS4 0.45 5.86 0.31 1.13e-8 Response to diuretic therapy; LUSC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg03452623 chr4:187889614 NA 0.52 7.83 0.39 6.39e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs3820068 0.608 rs12091750 chr1:16042766 T/C cg24675056 chr1:15929824 NA 0.41 6.84 0.35 3.9e-11 Systolic blood pressure; LUSC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg22834771 chr12:69754056 YEATS4 -0.45 -6.46 -0.33 3.72e-10 Blood protein levels; LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.58 0.46 2.27e-19 Bipolar disorder; LUSC cis rs8017423 0.967 rs4904656 chr14:90721442 G/T cg14092571 chr14:90743983 NA -0.35 -5.83 -0.3 1.29e-8 Mortality in heart failure; LUSC cis rs10761482 0.500 rs4540900 chr10:62308734 C/T cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.58e-12 Schizophrenia; LUSC cis rs2708977 0.730 rs596069 chr2:97076642 C/T cg01950434 chr2:97203154 ARID5A 0.47 6.72 0.34 7.98e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg15605315 chr1:45957053 TESK2 -0.39 -5.98 -0.31 5.67e-9 Red blood cell count;Reticulocyte count; LUSC cis rs10883723 0.962 rs1056741 chr10:104236640 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 12.07 0.55 4.52e-28 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg18904891 chr8:8559673 CLDN23 -0.41 -6.28 -0.32 1.05e-9 Mood instability; LUSC cis rs9393692 0.905 rs2393592 chr6:26285560 A/G cg13736514 chr6:26305472 NA -0.46 -9.19 -0.45 4.3e-18 Educational attainment; LUSC cis rs9616064 0.740 rs6520049 chr22:46996309 C/T cg25730555 chr22:47059586 GRAMD4 0.44 6.96 0.36 1.79e-11 Urate levels in obese individuals; LUSC cis rs12980942 0.748 rs35501756 chr19:41823497 G/A cg25627403 chr19:41769009 HNRNPUL1 0.57 6.14 0.32 2.37e-9 Coronary artery disease; LUSC trans rs17767294 0.522 rs78037434 chr6:27848898 A/T cg23539494 chr17:65276751 NA 0.76 6.31 0.33 8.83e-10 Parkinson's disease; LUSC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg18827107 chr12:86230957 RASSF9 0.45 6.86 0.35 3.4e-11 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20204401 chr17:78010341 CCDC40;TBC1D16 -0.43 -6.31 -0.33 9.01e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs459571 0.920 rs455073 chr9:136909141 G/C cg13789015 chr9:136890014 NCRNA00094 0.72 13.06 0.58 8.81e-32 Platelet distribution width; LUSC cis rs36715 1.000 rs36702 chr5:127552723 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.48 6.67 0.34 1.04e-10 Breast cancer; LUSC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg00343986 chr7:65444356 GUSB -0.41 -6.07 -0.32 3.41e-9 Aortic root size; LUSC cis rs9326248 0.581 rs7121898 chr11:116796846 A/T cg11861562 chr11:117069780 TAGLN 0.35 6.81 0.35 4.51e-11 Blood protein levels; LUSC cis rs10740039 0.810 rs1442543 chr10:62373462 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.89 -0.35 2.85e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs11992162 0.591 rs35657308 chr8:11804402 G/A cg27411982 chr8:10470053 RP1L1 -0.39 -5.95 -0.31 6.62e-9 Monocyte count; LUSC cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg26597838 chr10:835615 NA -0.49 -6.68 -0.34 1.02e-10 Response to angiotensin II receptor blocker therapy; LUSC trans rs60843830 1.000 rs58461606 chr2:267367 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.35 0.49 5.71e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg02782426 chr3:40428986 ENTPD3 0.41 7.71 0.39 1.41e-13 Renal cell carcinoma; LUSC cis rs9287719 0.967 rs2287061 chr2:10743153 C/T cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs2486288 0.586 rs12909625 chr15:45572053 C/A cg09092052 chr15:45571596 NA 0.46 6.34 0.33 7.51e-10 Glomerular filtration rate; LUSC cis rs2797160 0.515 rs9375409 chr6:125972798 A/G cg05901451 chr6:126070800 HEY2 -0.41 -5.88 -0.31 9.89e-9 Endometrial cancer; LUSC cis rs2562152 0.654 rs216600 chr16:110165 T/C cg02949481 chr16:131562 MPG 0.48 5.78 0.3 1.69e-8 Glioblastoma; LUSC trans rs7726839 0.794 rs6883536 chr5:599274 G/A cg25482853 chr8:67687455 SGK3 0.79 10.99 0.52 3.39e-24 Obesity-related traits; LUSC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.48 0.38 6.75e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11711311 1.000 rs13061150 chr3:113506734 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.86 -0.31 1.1e-8 IgG glycosylation; LUSC cis rs7590720 0.731 rs1864253 chr2:216878008 C/G cg12620499 chr2:216877984 MREG 0.98 17.83 0.7 1.88e-50 Alcohol dependence; LUSC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.03 0.31 4.3e-9 Schizophrenia; LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 -0.47 -7.97 -0.4 2.58e-14 Vitiligo; LUSC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg02221750 chr19:17393354 ANKLE1 0.9 14.52 0.62 2.26e-37 Systemic lupus erythematosus; LUSC cis rs6500602 0.727 rs4786515 chr16:4578133 T/A cg08645402 chr16:4508243 NA 0.52 8.82 0.43 6.66e-17 Schizophrenia; LUSC cis rs500891 0.525 rs9800770 chr6:84070313 C/T cg08257003 chr6:84140564 ME1 0.35 8.49 0.42 6.69e-16 Platelet-derived growth factor BB levels; LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg20887711 chr4:1340912 KIAA1530 -0.65 -10.08 -0.48 4.75e-21 Obesity-related traits; LUSC trans rs561341 1.000 rs55962687 chr17:30260369 C/T cg20587970 chr11:113659929 NA -1.27 -15.95 -0.66 5.89e-43 Hip circumference adjusted for BMI; LUSC cis rs2860975 1.000 rs11188133 chr10:96772015 G/A cg09036531 chr10:96991505 NA -0.41 -5.72 -0.3 2.35e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs7267979 1.000 rs6138575 chr20:25438952 G/A cg08601574 chr20:25228251 PYGB 0.42 6.29 0.33 9.95e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11992162 0.967 rs7836456 chr8:11829175 T/G cg27411982 chr8:10470053 RP1L1 0.49 7.66 0.39 1.99e-13 Monocyte count; LUSC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg04287289 chr16:89883240 FANCA 0.54 8.4 0.42 1.26e-15 Vitiligo; LUSC cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg08213375 chr14:104286397 PPP1R13B 0.46 8.28 0.41 2.9e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg02772935 chr3:125709198 NA -0.48 -5.76 -0.3 1.91e-8 Blood pressure (smoking interaction); LUSC cis rs30380 0.632 rs27045 chr5:96138861 C/T cg16492584 chr5:96139282 ERAP1 -0.58 -7.83 -0.39 6.65e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg14440974 chr22:39074834 NA 0.34 5.72 0.3 2.31e-8 Menopause (age at onset); LUSC cis rs1790761 0.632 rs625978 chr11:67344664 C/T cg14500267 chr11:67383377 NA 0.35 6.6 0.34 1.66e-10 Mean corpuscular volume; LUSC cis rs10170846 1.000 rs10170846 chr2:223517705 C/G cg25565276 chr2:223520875 FARSB -0.67 -10.05 -0.48 6.17e-21 Schizophrenia (inflammation and infection response interaction); LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg22331096 chr8:128749328 MYC 0.39 6.1 0.32 2.87e-9 Schizophrenia (age at onset); LUSC cis rs7707921 1.000 rs1019806 chr5:81551659 G/A cg15871215 chr5:81402204 ATG10 0.44 6.43 0.33 4.35e-10 Breast cancer; LUSC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.7 -0.34 9.12e-11 Alzheimer's disease (late onset); LUSC trans rs1499614 1.000 rs2707840 chr7:66158015 C/T cg10756647 chr7:56101905 PSPH 0.86 8.51 0.42 6.01e-16 Gout; LUSC cis rs9560113 0.573 rs9560133 chr13:112240013 C/A cg10483660 chr13:112241077 NA 0.36 6.15 0.32 2.18e-9 Menarche (age at onset); LUSC cis rs7315438 0.560 rs12824482 chr12:115888507 C/T cg24172291 chr12:115889509 NA -0.34 -5.82 -0.3 1.41e-8 Colorectal cancer; LUSC cis rs9916302 0.821 rs11078916 chr17:37746307 T/C cg07936489 chr17:37558343 FBXL20 -0.55 -7.34 -0.37 1.61e-12 Glomerular filtration rate (creatinine); LUSC cis rs9311676 0.656 rs62258093 chr3:58371745 T/C cg13750441 chr3:58318267 PXK 0.35 6.7 0.34 9.04e-11 Systemic lupus erythematosus; LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1018836 0.923 rs4735268 chr8:91629715 C/T cg16814680 chr8:91681699 NA -0.77 -12.73 -0.57 1.56e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -7.46 -0.38 7.78e-13 Developmental language disorder (linguistic errors); LUSC cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -7.97 -0.4 2.52e-14 Bone mineral density; LUSC cis rs709400 1.000 rs3783404 chr14:104118498 A/G cg24130564 chr14:104152367 KLC1 -0.51 -7.42 -0.38 9.85e-13 Body mass index; LUSC trans rs9380880 0.826 rs2273062 chr6:39550935 C/A cg19893670 chr10:60097505 UBE2D1 0.65 5.96 0.31 6.24e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs6964587 1.000 rs7802788 chr7:91736874 A/G cg17063962 chr7:91808500 NA 0.58 9.13 0.45 6.85e-18 Breast cancer; LUSC cis rs9549367 0.789 rs12584008 chr13:113881228 C/T cg00898013 chr13:113819073 PROZ -0.57 -8.06 -0.4 1.38e-14 Platelet distribution width; LUSC cis rs9560113 1.000 rs60374273 chr13:112179206 A/T cg14154082 chr13:112174009 NA 0.37 7.68 0.39 1.77e-13 Menarche (age at onset); LUSC trans rs1941687 0.797 rs9953948 chr18:31399399 G/A cg27147174 chr7:100797783 AP1S1 -0.44 -6.34 -0.33 7.57e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg23758822 chr17:41437982 NA 1.05 19.04 0.72 3.07e-55 Menopause (age at onset); LUSC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC trans rs7824557 0.527 rs4634600 chr8:11239017 T/A cg08975724 chr8:8085496 FLJ10661 -0.4 -6.01 -0.31 4.99e-9 Retinal vascular caliber; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg16162350 chr3:168867412 MECOM 0.74 6.53 0.34 2.45e-10 Body mass index; LUSC cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg03433033 chr1:76189801 ACADM 0.8 12.93 0.58 2.67e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg11301795 chr4:187892539 NA -0.81 -16.0 -0.66 3.69e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9287719 0.967 rs12995159 chr2:10753323 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg13607699 chr17:42295918 UBTF 0.49 7.71 0.39 1.43e-13 Total body bone mineral density; LUSC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg17264618 chr3:40429014 ENTPD3 -0.31 -6.47 -0.33 3.55e-10 Renal cell carcinoma; LUSC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg09877947 chr5:131593287 PDLIM4 0.48 7.81 0.39 7.72e-14 Breast cancer; LUSC cis rs6681460 0.932 rs602513 chr1:67177270 G/A cg02459107 chr1:67143332 SGIP1 0.49 9.12 0.45 7.42e-18 Presence of antiphospholipid antibodies; LUSC cis rs6982240 0.514 rs10481414 chr8:142275326 T/C cg00131261 chr8:142287264 NA -0.36 -6.05 -0.31 3.99e-9 Tonsillectomy; LUSC trans rs6951245 1.000 rs1997243 chr7:1083777 A/G cg13565492 chr6:43139072 SRF -0.57 -6.05 -0.31 3.93e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7769051 0.711 rs9493435 chr6:133088205 A/G cg07930552 chr6:133119739 C6orf192 0.73 9.48 0.46 5e-19 Type 2 diabetes nephropathy; LUSC cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg07606381 chr6:8435919 SLC35B3 -0.71 -11.44 -0.53 8.44e-26 Motion sickness; LUSC cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1775715 0.737 rs2799015 chr10:32107712 C/T cg04359828 chr10:32216031 ARHGAP12 0.41 6.95 0.36 1.95e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.39 -5.79 -0.3 1.58e-8 Schizophrenia; LUSC cis rs2797160 1.000 rs2747723 chr6:126010790 C/T cg05901451 chr6:126070800 HEY2 0.56 8.46 0.42 8.35e-16 Endometrial cancer; LUSC cis rs6723226 0.699 rs805830 chr2:32501475 T/C cg02381751 chr2:32503542 YIPF4 0.62 9.19 0.45 4.35e-18 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.89 0.61 6.08e-35 Platelet count; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg23978390 chr7:1156363 C7orf50 0.5 7.1 0.36 7.49e-12 Longevity;Endometriosis; LUSC cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg06092702 chr1:163392909 NA -0.47 -7.82 -0.39 7.14e-14 Motion sickness; LUSC trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg23505145 chr19:12996616 KLF1 0.64 10.77 0.51 2.08e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs1971762 0.583 rs1864448 chr12:54087856 T/G cg23533419 chr12:54090519 NA -0.38 -6.2 -0.32 1.64e-9 Height; LUSC cis rs2354432 0.607 rs1530336 chr1:146685121 G/A cg25205988 chr1:146714368 CHD1L 1.08 8.58 0.42 3.65e-16 Mitochondrial DNA levels; LUSC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.55 7.97 0.4 2.51e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1775715 0.737 rs2799017 chr10:32203460 A/G cg26784012 chr10:32216390 ARHGAP12 0.47 7.91 0.4 3.91e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg14343924 chr8:8086146 FLJ10661 -0.38 -5.69 -0.3 2.73e-8 Mood instability; LUSC cis rs897080 0.552 rs1067326 chr2:44628605 T/A cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg18827107 chr12:86230957 RASSF9 -0.44 -6.56 -0.34 2.07e-10 Major depressive disorder; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg27050229 chr1:856693 NA 0.5 6.03 0.31 4.45e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9547692 1.000 rs9531993 chr13:37475197 G/C cg01493522 chr13:37497338 NA -0.42 -6.23 -0.32 1.37e-9 Coronary artery disease; LUSC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg22532475 chr10:104410764 TRIM8 0.3 6.0 0.31 5.1e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13256369 0.851 rs13266562 chr8:8564065 T/C cg18904891 chr8:8559673 CLDN23 0.59 8.15 0.41 7.49e-15 Obesity-related traits; LUSC trans rs637571 0.522 rs28578718 chr11:65748400 C/A cg17712092 chr4:129076599 LARP1B 0.74 11.09 0.52 1.54e-24 Eosinophil percentage of white cells; LUSC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -6.43 -0.33 4.33e-10 Neutrophil percentage of white cells; LUSC cis rs7937682 0.921 rs7130753 chr11:111470567 C/T cg19812747 chr11:111475976 SIK2 0.55 7.72 0.39 1.39e-13 Primary sclerosing cholangitis; LUSC cis rs899997 1.000 rs11072793 chr15:79006442 C/T cg04896959 chr15:78267971 NA 0.51 10.78 0.51 1.95e-23 Coronary artery disease or large artery stroke; LUSC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg20283391 chr11:68216788 NA -0.55 -8.13 -0.41 8.23e-15 Total body bone mineral density; LUSC cis rs9287719 0.934 rs6710033 chr2:10757677 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs6084875 0.840 rs2422936 chr20:4720830 C/T cg07258627 chr20:4721683 PRNT -0.34 -6.07 -0.32 3.4e-9 Systemic lupus erythematosus; LUSC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg01416388 chr22:39784598 NA -0.44 -6.79 -0.35 5.15e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs629535 0.734 rs542288 chr8:70057149 G/T cg21567404 chr3:27674614 NA -0.95 -15.52 -0.65 2.84e-41 Dupuytren's disease; LUSC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg06634786 chr22:41940651 POLR3H -0.5 -6.24 -0.32 1.29e-9 Vitiligo; LUSC cis rs9902453 0.967 rs4294864 chr17:28440138 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.14 0.41 8.12e-15 Coffee consumption (cups per day); LUSC cis rs597583 0.806 rs2276339 chr11:117395481 G/A cg27161313 chr11:117392002 DSCAML1 -0.42 -7.06 -0.36 9.78e-12 Putamen volume; LUSC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs477692 0.967 rs488143 chr10:131407369 A/C cg26102564 chr10:131424627 MGMT 0.4 6.29 0.33 9.76e-10 Response to temozolomide; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg25036284 chr2:26402008 FAM59B 0.77 11.34 0.53 1.89e-25 Gut microbiome composition (summer); LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.25 0.52 4.18e-25 Menopause (age at onset); LUSC cis rs4909189 0.957 rs11766348 chr7:158135857 G/A cg06219351 chr7:158114137 PTPRN2 -0.54 -8.37 -0.42 1.65e-15 Response to amphetamines; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22559669 chr4:99580121 TSPAN5 -0.4 -6.08 -0.32 3.35e-9 Electrocardiographic conduction measures; LUSC cis rs4631830 0.900 rs9787697 chr10:51533376 C/T cg20129853 chr10:51489980 NA -0.35 -7.0 -0.36 1.38e-11 Prostate-specific antigen levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21362455 chr6:24495072 ALDH5A1 0.78 6.26 0.32 1.17e-9 Cognitive performance; LUSC trans rs9951602 0.512 rs4799245 chr18:76653397 T/C cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs600231 0.708 rs3132767 chr11:65234860 C/T cg17120908 chr11:65337727 SSSCA1 -0.54 -9.3 -0.45 1.9e-18 Bone mineral density; LUSC trans rs890448 0.796 rs1426541 chr4:102356859 C/T cg05120309 chr14:100485494 NA -0.36 -5.96 -0.31 6.38e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg04369109 chr6:150039330 LATS1 -0.55 -8.1 -0.41 1.07e-14 Lung cancer; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.57 -9.52 -0.46 3.5e-19 Lymphocyte counts; LUSC cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg27129171 chr3:47204927 SETD2 0.69 11.66 0.54 1.33e-26 Colorectal cancer; LUSC cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.17 0.52 7.91e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs35306767 0.668 rs12784928 chr10:1083617 A/C cg20503657 chr10:835505 NA 0.54 7.17 0.37 4.71e-12 Eosinophil percentage of granulocytes; LUSC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg04727924 chr7:799746 HEATR2 -0.54 -6.52 -0.34 2.67e-10 Cerebrospinal P-tau181p levels; LUSC cis rs9646944 0.501 rs36049530 chr2:103079988 T/C cg20060108 chr2:102954350 IL1RL1 0.45 6.08 0.32 3.22e-9 Blood protein levels; LUSC cis rs7647973 0.588 rs4855848 chr3:49653457 C/T cg03060546 chr3:49711283 APEH 0.63 7.53 0.38 4.92e-13 Menarche (age at onset); LUSC cis rs4363385 0.510 rs11576797 chr1:153049417 T/C cg25856811 chr1:152973957 SPRR3 -0.39 -6.35 -0.33 6.9e-10 Inflammatory skin disease; LUSC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg17724175 chr1:150552817 MCL1 0.37 6.75 0.35 6.64e-11 Tonsillectomy; LUSC cis rs1448094 0.967 rs1374995 chr12:86341764 A/G cg00310523 chr12:86230176 RASSF9 0.38 6.91 0.35 2.48e-11 Major depressive disorder; LUSC cis rs7605827 0.930 rs4668919 chr2:15662171 C/T cg19274914 chr2:15703543 NA 0.45 8.69 0.43 1.69e-16 Educational attainment (years of education); LUSC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg12463550 chr7:65579703 CRCP -0.45 -6.7 -0.34 9.11e-11 Aortic root size; LUSC trans rs61931739 0.534 rs10844800 chr12:34230734 A/G cg26384229 chr12:38710491 ALG10B 0.73 11.94 0.55 1.27e-27 Morning vs. evening chronotype; LUSC cis rs4561483 0.831 rs8052900 chr16:11940390 T/C cg08843971 chr16:11963173 GSPT1 0.41 6.0 0.31 5.23e-9 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6502050 0.787 rs11653012 chr17:80058857 C/T cg13939156 chr17:80058883 NA 0.35 7.15 0.36 5.4e-12 Life satisfaction; LUSC trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg15704280 chr7:45808275 SEPT13 -0.46 -6.29 -0.33 1e-9 HDL cholesterol; LUSC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg22875332 chr1:76189707 ACADM 0.83 13.94 0.61 3.99e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.46 -6.22 -0.32 1.45e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC trans rs45509595 0.841 rs401754 chr6:27782538 T/A cg01620082 chr3:125678407 NA -0.69 -7.05 -0.36 1.06e-11 Breast cancer; LUSC trans rs208520 0.690 rs12209753 chr6:66703951 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.06 16.59 0.67 1.7e-45 Exhaled nitric oxide output; LUSC trans rs10802346 0.545 rs10802345 chr1:246372834 C/T cg13514129 chr1:39547527 MACF1 0.71 11.81 0.54 4.07e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg03146154 chr1:46216737 IPP -0.38 -5.86 -0.31 1.11e-8 Red blood cell count;Reticulocyte count; LUSC cis rs2354432 0.607 rs1890039 chr1:146681951 T/C cg25205988 chr1:146714368 CHD1L 1.08 8.58 0.42 3.65e-16 Mitochondrial DNA levels; LUSC cis rs55665837 1.000 rs10832254 chr11:14434698 A/G cg19336497 chr11:14380999 RRAS2 -0.37 -7.51 -0.38 5.34e-13 Vitamin D levels; LUSC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg16414030 chr3:133502952 NA -0.41 -6.44 -0.33 4.16e-10 Iron status biomarkers; LUSC cis rs8062405 0.755 rs62034355 chr16:28581038 G/C cg16576597 chr16:28551801 NUPR1 0.34 6.77 0.35 5.67e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10791323 0.572 rs4353292 chr11:133742656 A/G cg15485101 chr11:133734466 NA 0.38 6.91 0.35 2.43e-11 Childhood ear infection; LUSC cis rs151234 0.676 rs151320 chr16:28568678 A/G cg01378222 chr16:28622494 SULT1A1 0.59 7.97 0.4 2.53e-14 Platelet distribution width; LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -10.24 -0.49 1.34e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 7.77 0.39 9.53e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs17125944 0.686 rs7160582 chr14:53341445 G/T cg00686598 chr14:53173677 PSMC6 0.79 6.85 0.35 3.63e-11 Alzheimer's disease (late onset); LUSC cis rs12148488 0.966 rs1867148 chr15:75339985 T/C cg09165964 chr15:75287851 SCAMP5 -0.48 -6.94 -0.36 2e-11 Caffeine consumption; LUSC cis rs2073300 1.000 rs6132621 chr20:23442180 C/T cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7726839 0.718 rs6887972 chr5:597274 C/G cg03128945 chr5:622914 CEP72 -0.47 -6.7 -0.34 8.81e-11 Obesity-related traits; LUSC cis rs9467711 0.790 rs13195402 chr6:26463575 G/T cg09904177 chr6:26538194 HMGN4 -0.79 -5.88 -0.31 1e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs6750047 0.585 rs4670235 chr2:38272528 C/T cg07380506 chr2:38303506 CYP1B1 0.45 6.11 0.32 2.71e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs11039100 0.765 rs72896130 chr11:5834405 C/T cg05234568 chr11:5960015 NA -0.51 -5.68 -0.3 2.95e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg05283184 chr6:79620031 NA -0.57 -11.83 -0.54 3.38e-27 Intelligence (multi-trait analysis); LUSC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.74 -13.87 -0.6 7.04e-35 Intelligence (multi-trait analysis); LUSC trans rs1941687 0.563 rs1586987 chr18:31338661 A/G cg27147174 chr7:100797783 AP1S1 -0.56 -8.9 -0.44 3.61e-17 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg24558204 chr6:135376177 HBS1L 0.68 10.46 0.5 2.49e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg12310025 chr6:25882481 NA 0.63 10.55 0.5 1.17e-22 Blood metabolite levels; LUSC cis rs7043114 0.525 rs1053441 chr9:95147840 T/A cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.51 -0.34 2.72e-10 Height; LUSC cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg04450456 chr4:17643702 FAM184B -0.39 -6.3 -0.33 9.3e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg08917208 chr2:24149416 ATAD2B 0.56 6.44 0.33 4.27e-10 Lymphocyte counts; LUSC cis rs11098499 0.754 rs10006259 chr4:120242145 C/T cg24375607 chr4:120327624 NA 0.76 12.23 0.56 1.14e-28 Corneal astigmatism; LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs9356985 chr6:25728098 C/T cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC trans rs6598955 0.585 rs11577098 chr1:26602525 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.53 -0.42 5.13e-16 Obesity-related traits; LUSC cis rs9309473 0.583 rs11899517 chr2:73573261 A/G cg20560298 chr2:73613845 ALMS1 -0.54 -7.72 -0.39 1.33e-13 Metabolite levels; LUSC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg18306943 chr3:40428807 ENTPD3 0.38 5.73 0.3 2.25e-8 Renal cell carcinoma; LUSC cis rs9427116 0.502 rs6699825 chr1:154582970 A/G cg17218026 chr1:154582156 ADAR 0.56 10.06 0.48 5.92e-21 Blood protein levels; LUSC cis rs3126085 0.935 rs1390490 chr1:152161354 T/C cg26876637 chr1:152193138 HRNR 0.44 5.92 0.31 7.94e-9 Atopic dermatitis; LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg09877947 chr5:131593287 PDLIM4 0.59 10.02 0.48 7.64e-21 Acylcarnitine levels; LUSC cis rs4308124 0.708 rs6716091 chr2:111991133 C/T cg04571233 chr2:111982156 NA -0.53 -6.95 -0.36 1.98e-11 Vitiligo; LUSC cis rs7914558 0.966 rs10748839 chr10:104953547 A/G cg04362960 chr10:104952993 NT5C2 0.58 9.38 0.46 1.04e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7927592 0.913 rs10896329 chr11:68250029 A/G cg16797656 chr11:68205561 LRP5 0.37 6.05 0.31 3.96e-9 Total body bone mineral density; LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg15790184 chr11:494944 RNH1 0.42 6.42 0.33 4.69e-10 Systemic lupus erythematosus; LUSC cis rs4964805 0.672 rs4964823 chr12:104181420 A/T cg02344784 chr12:104178138 NT5DC3 0.42 6.6 0.34 1.57e-10 Attention deficit hyperactivity disorder; LUSC trans rs9650657 0.769 rs2116093 chr8:10613299 C/G cg15556689 chr8:8085844 FLJ10661 -0.4 -6.01 -0.31 4.82e-9 Neuroticism; LUSC cis rs7923609 0.936 rs10740125 chr10:65209609 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.03e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs629535 0.590 rs62513426 chr8:70136843 T/G cg21567404 chr3:27674614 NA -0.93 -13.53 -0.6 1.45e-33 Dupuytren's disease; LUSC cis rs7814319 0.966 rs10112328 chr8:97254372 C/T cg20787634 chr8:97240163 UQCRB 0.33 5.73 0.3 2.22e-8 Lung function (FVC); LUSC cis rs2439831 1.000 rs565007 chr15:43716641 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.88 0.44 4.07e-17 Lung cancer in ever smokers; LUSC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg05472934 chr7:22766657 IL6 0.5 7.84 0.39 6.13e-14 Lung cancer; LUSC cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg01256987 chr12:42539512 GXYLT1 -0.46 -8.74 -0.43 1.18e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7267979 0.844 rs4815413 chr20:25359229 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -16.94 -0.68 6.65e-47 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5769765 0.565 rs8137232 chr22:50256885 G/C cg22709217 chr22:50311962 ALG12;CRELD2 0.62 6.55 0.34 2.16e-10 Schizophrenia; LUSC trans rs6601327 0.613 rs11785458 chr8:9506810 T/C cg15556689 chr8:8085844 FLJ10661 -0.44 -6.17 -0.32 2.01e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs4356932 0.691 rs2242473 chr4:76878956 G/A cg00809888 chr4:76862425 NAAA -0.36 -5.72 -0.3 2.31e-8 Blood protein levels; LUSC cis rs9837602 0.938 rs1017968 chr3:99787011 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.91 -0.31 8.57e-9 Breast cancer; LUSC trans rs2840044 1.000 rs9913003 chr17:33893904 C/A cg19694781 chr19:47549865 TMEM160 0.59 9.52 0.46 3.59e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs6700896 0.866 rs6588158 chr1:66160621 T/C cg04111102 chr1:66153794 NA -0.34 -7.42 -0.38 1e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6977940 0.512 rs6461600 chr7:2816537 C/T cg14895029 chr7:2775587 GNA12 0.45 5.66 0.3 3.29e-8 White matter integrity; LUSC cis rs12599106 0.839 rs3853177 chr16:34498532 A/G cg01585723 chr16:33734837 NA 0.35 5.68 0.3 2.88e-8 Menopause (age at onset); LUSC cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.35 0.46 1.3e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg24549020 chr5:56110836 MAP3K1 0.48 5.71 0.3 2.46e-8 Initial pursuit acceleration; LUSC cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg06547715 chr2:218990976 CXCR2 -0.34 -6.76 -0.35 6.12e-11 Ulcerative colitis; LUSC cis rs8114671 0.562 rs6120739 chr20:33405227 A/G cg08999081 chr20:33150536 PIGU 0.33 5.81 0.3 1.42e-8 Height; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg24675658 chr1:53192096 ZYG11B 0.58 9.11 0.45 7.92e-18 Monocyte count; LUSC cis rs11190604 1.000 rs11190572 chr10:102232879 A/G cg07080220 chr10:102295463 HIF1AN 0.64 8.46 0.42 8.63e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2050392 0.687 rs608693 chr10:30734971 G/A cg25182066 chr10:30743637 MAP3K8 -0.4 -6.0 -0.31 5.16e-9 Inflammatory bowel disease; LUSC cis rs7799006 0.606 rs878534 chr7:2314652 G/A cg02951883 chr7:2050386 MAD1L1 -0.36 -5.85 -0.3 1.2e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg12292205 chr6:26970375 C6orf41 -0.58 -7.16 -0.36 5.14e-12 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.83 0.39 6.53e-14 Prudent dietary pattern; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00668442 chr16:2318234 RNPS1 0.77 6.08 0.32 3.35e-9 Cognitive performance; LUSC cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg18132916 chr6:79620363 NA 0.39 5.88 0.31 9.86e-9 Intelligence (multi-trait analysis); LUSC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg23283495 chr1:209979779 IRF6 0.64 9.3 0.45 1.96e-18 Cleft lip with or without cleft palate; LUSC cis rs2688608 0.592 rs7923045 chr10:75487498 A/T cg23231163 chr10:75533350 FUT11 -0.38 -6.32 -0.33 8.41e-10 Inflammatory bowel disease; LUSC trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg03929089 chr4:120376271 NA -0.77 -10.43 -0.5 3.05e-22 Coronary artery disease; LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg17968037 chr7:100024898 ZCWPW1 -0.43 -6.14 -0.32 2.32e-9 Platelet count; LUSC cis rs9283706 0.689 rs1030231 chr5:66317265 A/G cg11590213 chr5:66331682 MAST4 0.48 6.8 0.35 4.95e-11 Coronary artery disease; LUSC cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg08109568 chr15:31115862 NA -0.54 -7.45 -0.38 7.93e-13 Huntington's disease progression; LUSC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg20608306 chr11:116969690 SIK3 0.36 6.78 0.35 5.58e-11 Blood protein levels; LUSC cis rs7647973 0.577 rs6446247 chr3:49102001 A/T cg07636037 chr3:49044803 WDR6 0.93 11.83 0.54 3.2e-27 Menarche (age at onset); LUSC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.56e-24 Aortic root size; LUSC cis rs6496667 0.533 rs2589949 chr15:90955015 C/T cg22089800 chr15:90895588 ZNF774 0.51 7.55 0.38 4.29e-13 Rheumatoid arthritis; LUSC trans rs2665103 0.715 rs16973457 chr15:82563991 C/T cg18393722 chr15:85113863 UBE2QP1 -0.42 -6.5 -0.34 2.89e-10 Intelligence (multi-trait analysis); LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg22864355 chr14:105225861 SIVA1 -0.36 -6.02 -0.31 4.63e-9 Schizophrenia (age at onset); LUSC cis rs1160297 0.576 rs13030509 chr2:53110287 T/A cg07782112 chr2:53107842 NA 0.39 6.47 0.33 3.55e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs4400599 1.000 rs4540651 chr1:154128672 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.99 -0.31 5.38e-9 Platelet distribution width; LUSC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg07701084 chr6:150067640 NUP43 0.49 7.39 0.37 1.22e-12 Lung cancer; LUSC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg04155289 chr7:94953770 PON1 -0.34 -5.68 -0.3 2.96e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg02353165 chr6:42928485 GNMT 0.67 11.81 0.54 3.97e-27 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3008870 0.755 rs10789219 chr1:67417742 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.42 0.56 2.19e-29 Lymphocyte percentage of white cells; LUSC cis rs11264799 0.520 rs2779159 chr1:157550357 C/T cg18268488 chr1:157545234 FCRL4 0.39 7.63 0.39 2.42e-13 IgA nephropathy; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13162328 chr8:22462125 KIAA1967 0.76 6.02 0.31 4.68e-9 Cognitive performance; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg22535103 chr8:58192502 C8orf71 -0.72 -7.89 -0.4 4.31e-14 Developmental language disorder (linguistic errors); LUSC trans rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05039488 chr6:79577232 IRAK1BP1 0.43 6.57 0.34 1.93e-10 Brugada syndrome; LUSC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.49 -0.46 4.49e-19 Gut microbiome composition (summer); LUSC cis rs68170813 0.559 rs2249043 chr7:106960515 C/T cg02696742 chr7:106810147 HBP1 -0.6 -9.09 -0.45 9.03e-18 Coronary artery disease; LUSC cis rs644799 0.710 rs1852535 chr11:95501241 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.09e-12 Mean platelet volume; LUSC cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 8.45 0.42 9.05e-16 Menarche (age at onset); LUSC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg12463550 chr7:65579703 CRCP 0.45 6.58 0.34 1.84e-10 Aortic root size; LUSC cis rs16976116 0.901 rs7165491 chr15:55500455 A/C cg11288833 chr15:55489084 RSL24D1 0.47 5.69 0.3 2.73e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8062405 0.792 rs12446550 chr16:28543381 G/A cg16576597 chr16:28551801 NUPR1 0.29 5.77 0.3 1.82e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs8040855 0.825 rs3964197 chr15:85721912 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.42 -6.39 -0.33 5.72e-10 Bulimia nervosa; LUSC cis rs2486288 0.656 rs7171312 chr15:45570225 C/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.7 -0.39 1.6e-13 Glomerular filtration rate; LUSC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg17385448 chr1:15911702 AGMAT 0.37 6.31 0.33 8.9e-10 Systolic blood pressure; LUSC trans rs853679 0.607 rs67662114 chr6:27932301 G/A cg09904177 chr6:26538194 HMGN4 -0.78 -5.94 -0.31 6.98e-9 Depression; LUSC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs934734 0.967 rs17534670 chr2:65615428 A/G cg08085232 chr2:65598271 SPRED2 0.39 5.99 0.31 5.29e-9 Rheumatoid arthritis; LUSC cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg00852783 chr1:26633632 UBXN11 0.6 9.31 0.45 1.78e-18 Granulocyte percentage of myeloid white cells; LUSC cis rs17407555 0.606 rs73229818 chr4:10019884 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.2 -0.32 1.68e-9 Schizophrenia (age at onset); LUSC cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg17553881 chr5:443987 EXOC3;C5orf55 0.29 5.92 0.31 8.2e-9 Cystic fibrosis severity; LUSC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg13770153 chr20:60521292 NA 0.73 9.94 0.48 1.4e-20 Body mass index; LUSC cis rs9560113 1.000 rs9560106 chr13:112179605 A/G cg14154082 chr13:112174009 NA 0.36 7.56 0.38 4.03e-13 Menarche (age at onset); LUSC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.27 -0.37 2.61e-12 Alzheimer's disease (late onset); LUSC cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg00071950 chr4:10020882 SLC2A9 0.57 9.5 0.46 4.29e-19 Bone mineral density; LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg23758822 chr17:41437982 NA -1.04 -19.43 -0.73 8.39e-57 Menopause (age at onset); LUSC cis rs6500395 1.000 rs8052196 chr16:48691644 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg01017244 chr2:74357527 NA 0.69 13.11 0.58 6.01e-32 Gestational age at birth (maternal effect); LUSC trans rs6951245 0.706 rs28483034 chr7:1170171 C/A cg13565492 chr6:43139072 SRF -0.59 -6.72 -0.35 7.91e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9527 0.567 rs6584539 chr10:104879402 G/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg00933542 chr6:150070202 PCMT1 0.32 6.79 0.35 5.15e-11 Lung cancer; LUSC cis rs8014204 0.804 rs2287403 chr14:75259140 C/T cg06637938 chr14:75390232 RPS6KL1 0.65 10.68 0.5 4.19e-23 Caffeine consumption; LUSC trans rs3733585 0.699 rs1079128 chr4:9951221 T/C cg26043149 chr18:55253948 FECH -0.43 -6.6 -0.34 1.64e-10 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3820928 0.874 rs2228557 chr2:227872182 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.55 -0.38 4.06e-13 Pulmonary function; LUSC cis rs34779708 0.931 rs7923217 chr10:35309589 A/G cg03585969 chr10:35415529 CREM 0.61 8.87 0.44 4.62e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6430585 0.528 rs614193 chr2:136653925 A/T cg07169764 chr2:136633963 MCM6 1.05 15.67 0.65 7.33e-42 Corneal structure; LUSC cis rs6456156 0.586 rs6456154 chr6:167472256 C/T cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs6700559 0.740 rs11582610 chr1:200645101 C/T cg07804481 chr1:200639085 DDX59 0.41 5.77 0.3 1.85e-8 Coronary artery disease; LUSC cis rs7605827 0.897 rs4140714 chr2:15515723 T/A cg19274914 chr2:15703543 NA 0.47 9.07 0.44 1.03e-17 Educational attainment (years of education); LUSC cis rs12931792 0.687 rs8057425 chr16:30182541 T/C cg17640201 chr16:30407289 ZNF48 0.63 10.23 0.49 1.46e-21 Tonsillectomy; LUSC cis rs394563 0.591 rs237029 chr6:149717425 A/G cg07828024 chr6:149772892 ZC3H12D -0.34 -7.36 -0.37 1.4e-12 Dupuytren's disease; LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg00166722 chr3:10149974 C3orf24 0.6 8.39 0.42 1.4e-15 Alzheimer's disease; LUSC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg17366294 chr4:99064904 C4orf37 0.59 10.56 0.5 1.07e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs12618769 0.597 rs4599165 chr2:99144483 G/A cg10123293 chr2:99228465 UNC50 0.46 7.54 0.38 4.34e-13 Bipolar disorder; LUSC trans rs12495832 0.778 rs12635085 chr3:147933337 A/T cg23651585 chr7:70252448 AUTS2 0.72 6.68 0.34 1.01e-10 Chin dimples; LUSC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg21854759 chr1:92012499 NA -0.49 -6.88 -0.35 3.04e-11 Eosinophil percentage of white cells; LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg18099408 chr3:52552593 STAB1 -0.38 -6.17 -0.32 1.92e-9 Bipolar disorder; LUSC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg14552801 chr7:65878734 NA -0.45 -6.44 -0.33 4.23e-10 Aortic root size; LUSC cis rs9430161 0.579 rs10864486 chr1:11040979 A/G cg27631724 chr1:11040367 C1orf127 0.55 10.65 0.5 5.36e-23 Ewing sarcoma; LUSC cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg05025164 chr4:1340916 KIAA1530 0.42 6.34 0.33 7.36e-10 Obesity-related traits; LUSC cis rs10493773 0.894 rs12067749 chr1:86197922 T/C cg17807903 chr1:86174739 ZNHIT6 -0.45 -9.88 -0.48 2.25e-20 Urate levels in overweight individuals; LUSC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg10018233 chr7:150070692 REPIN1 0.4 6.7 0.34 8.7e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs12310956 0.532 rs1906134 chr12:33957135 A/C cg06521331 chr12:34319734 NA -0.45 -7.23 -0.37 3.3e-12 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs11053198 chr12:34444013 G/C cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.32e-18 Morning vs. evening chronotype; LUSC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 14.03 0.61 1.83e-35 Smoking behavior; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.53 0.42 5.04e-16 Prudent dietary pattern; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg08859206 chr1:53392774 SCP2 0.5 8.66 0.43 2e-16 Monocyte count; LUSC cis rs11158026 0.603 rs8009997 chr14:55421911 A/C cg04306507 chr14:55594613 LGALS3 0.34 5.96 0.31 6.24e-9 Parkinson's disease; LUSC cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.88e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3820928 1.000 rs4675116 chr2:227769607 A/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.73 -0.39 1.3e-13 Pulmonary function; LUSC cis rs11608355 0.960 rs10774691 chr12:109859830 C/T cg05360138 chr12:110035743 NA 0.47 6.35 0.33 6.87e-10 Neuroticism; LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg09184832 chr6:79620586 NA 0.43 7.12 0.36 6.62e-12 Intelligence (multi-trait analysis); LUSC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg20119798 chr7:94954144 PON1 -0.33 -5.66 -0.3 3.28e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7586879 1.000 rs7586879 chr2:25116977 C/T cg01884057 chr2:25150051 NA 0.42 9.15 0.45 5.56e-18 Body mass index; LUSC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg11742103 chr11:62369870 EML3;MTA2 -0.54 -8.99 -0.44 1.83e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2742417 1.000 rs1534876 chr3:45741257 G/T cg04837898 chr3:45731254 SACM1L -0.35 -5.86 -0.31 1.08e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs508618 1.000 rs508618 chr1:231532312 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -6.6 -0.34 1.63e-10 Red blood cell count; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg17541715 chr7:1216824 NA -0.39 -6.14 -0.32 2.32e-9 Longevity;Endometriosis; LUSC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg19729930 chr2:74357872 NA 0.88 16.45 0.67 5.83e-45 Gestational age at birth (maternal effect); LUSC trans rs330048 0.509 rs36111783 chr8:9145588 A/G cg06636001 chr8:8085503 FLJ10661 0.45 6.27 0.32 1.13e-9 Systemic lupus erythematosus; LUSC cis rs748404 0.697 rs498227 chr15:43573052 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.42 5.95 0.31 6.74e-9 Lung cancer; LUSC cis rs7617480 0.648 rs9882443 chr3:48749064 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.6 9.1 0.45 8.3e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg16606324 chr3:10149918 C3orf24 0.65 9.52 0.46 3.55e-19 Alzheimer's disease; LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.44 0.38 8.45e-13 Bipolar disorder; LUSC cis rs2806561 0.765 rs641808 chr1:23514123 T/G cg19743168 chr1:23544995 NA 0.4 7.96 0.4 2.78e-14 Height; LUSC cis rs9815354 0.767 rs17281609 chr3:41833432 G/A cg03022575 chr3:42003672 ULK4 0.86 8.67 0.43 1.97e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9902453 0.740 rs2617867 chr17:28049399 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.16 -0.52 8.29e-25 Coffee consumption (cups per day); LUSC cis rs9905704 0.846 rs304298 chr17:56839689 G/A cg12560992 chr17:57184187 TRIM37 0.58 8.38 0.42 1.5e-15 Testicular germ cell tumor; LUSC cis rs600626 0.636 rs11236518 chr11:75453066 C/T cg24262691 chr11:75473276 NA 0.48 6.5 0.34 2.85e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg07777115 chr5:623756 CEP72 -0.45 -5.65 -0.3 3.5e-8 Obesity-related traits; LUSC cis rs7208859 0.623 rs7223404 chr17:29107363 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs4629710 0.645 rs34601891 chr6:131551238 C/T cg12606694 chr6:131520996 AKAP7 0.62 9.37 0.46 1.12e-18 Multiple myeloma (IgH translocation); LUSC cis rs10504229 1.000 rs57378064 chr8:58169844 C/G cg05313129 chr8:58192883 C8orf71 -0.5 -6.78 -0.35 5.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg20283391 chr11:68216788 NA -0.57 -8.23 -0.41 4.21e-15 Total body bone mineral density; LUSC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.41 -0.38 1.03e-12 Aortic root size; LUSC cis rs2625529 0.627 rs12902661 chr15:72480158 T/G cg16672083 chr15:72433130 SENP8 -0.5 -7.29 -0.37 2.31e-12 Red blood cell count; LUSC cis rs66887589 0.616 rs13113885 chr4:120221176 G/C cg24375607 chr4:120327624 NA 0.49 7.29 0.37 2.21e-12 Diastolic blood pressure; LUSC cis rs3820068 0.608 rs7519899 chr1:16045579 A/G cg13390004 chr1:15929781 NA 0.41 6.53 0.34 2.44e-10 Systolic blood pressure; LUSC cis rs6580649 0.941 rs1793933 chr12:48396450 G/T cg05342945 chr12:48394962 COL2A1 -0.45 -6.01 -0.31 4.94e-9 Lung cancer; LUSC trans rs7520050 0.966 rs11589562 chr1:46466721 C/T cg12165782 chr19:1675947 NA -0.34 -5.99 -0.31 5.57e-9 Red blood cell count;Reticulocyte count; LUSC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg00933542 chr6:150070202 PCMT1 0.3 6.07 0.32 3.4e-9 Lung cancer; LUSC cis rs16949788 1.000 rs78288367 chr15:66772721 C/T cg08120210 chr15:66682733 MAP2K1 -0.63 -6.52 -0.34 2.61e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg11247378 chr22:39784982 NA -0.64 -12.36 -0.56 3.67e-29 Intelligence (multi-trait analysis); LUSC cis rs926392 0.932 rs6513589 chr20:37686585 A/G cg27552599 chr20:37590471 DHX35 0.33 5.71 0.3 2.54e-8 Dialysis-related mortality; LUSC cis rs2404602 0.692 rs34287706 chr15:76942402 A/C cg22467129 chr15:76604101 ETFA -0.42 -6.69 -0.34 9.56e-11 Blood metabolite levels; LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg06145435 chr7:1022769 CYP2W1 0.27 5.66 0.3 3.19e-8 Longevity;Endometriosis; LUSC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.16 0.41 6.87e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg19628046 chr18:33552617 C18orf21 0.51 6.1 0.32 2.94e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs34891900 0.507 rs2587084 chr22:18140644 T/G cg19898043 chr22:18121309 BCL2L13 0.39 5.98 0.31 5.84e-9 Sum neutrophil eosinophil counts; LUSC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.94 0.4 3.01e-14 Hemoglobin concentration; LUSC trans rs6502050 0.835 rs11077971 chr17:80090629 A/G cg07393940 chr7:158741817 NA 0.39 7.09 0.36 8.09e-12 Life satisfaction; LUSC cis rs1577917 0.958 rs4707223 chr6:86509802 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.79 -0.43 8.09e-17 Response to antipsychotic treatment; LUSC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg04369109 chr6:150039330 LATS1 -0.56 -8.22 -0.41 4.62e-15 Lung cancer; LUSC cis rs644799 0.635 rs10831428 chr11:95508404 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.05 0.61 1.44e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10779751 1.000 rs2300094 chr1:11266044 C/T cg08854313 chr1:11322531 MTOR 0.91 16.1 0.66 1.5e-43 Body mass index; LUSC cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg13736514 chr6:26305472 NA -0.45 -8.94 -0.44 2.72e-17 Educational attainment; LUSC cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg07148914 chr20:33460835 GGT7 0.54 8.4 0.42 1.29e-15 Height; LUSC cis rs7804356 1.000 rs3213853 chr7:26893524 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.56e-9 Type 1 diabetes; LUSC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg18876405 chr7:65276391 NA -0.65 -11.63 -0.54 1.83e-26 Aortic root size; LUSC cis rs7582180 0.606 rs11684004 chr2:100954783 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.72 0.3 2.42e-8 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.647 rs11852395 chr15:77087785 T/C cg23625390 chr15:77176239 SCAPER -0.65 -9.83 -0.47 3.49e-20 Blood metabolite levels; LUSC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg18681998 chr4:17616180 MED28 0.84 15.62 0.65 1.13e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg11244672 chr19:19639970 YJEFN3 -0.58 -7.04 -0.36 1.12e-11 Bipolar disorder; LUSC cis rs72960926 0.590 rs72959617 chr6:74993963 G/A cg03266952 chr6:74778945 NA -0.8 -6.78 -0.35 5.51e-11 Metabolite levels (MHPG); LUSC cis rs12545109 0.775 rs10093388 chr8:57318799 C/T cg09654669 chr8:57350985 NA -0.62 -8.46 -0.42 8.51e-16 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02335971 chr8:121457381 MTBP;MRPL13 -0.38 -6.13 -0.32 2.41e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6736093 0.966 rs13027171 chr2:112686988 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.91 -0.31 8.29e-9 Coronary artery disease; LUSC cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg05043794 chr9:111880884 C9orf5 -0.31 -6.49 -0.33 3.1e-10 Menarche (age at onset); LUSC cis rs12989701 0.778 rs7583814 chr2:127863029 C/T cg08168897 chr2:127865431 BIN1 0.7 8.73 0.43 1.27e-16 Alzheimer's disease (late onset); LUSC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg00908189 chr16:619842 PIGQ 0.68 10.94 0.51 5.03e-24 Height; LUSC cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs57920188 0.584 rs12062024 chr1:4089259 A/T cg20703997 chr1:4087676 NA -0.58 -8.75 -0.43 1.09e-16 Interleukin-17 levels; LUSC cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg06784218 chr1:46089804 CCDC17 0.48 9.63 0.47 1.62e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1577917 0.740 rs2758842 chr6:86308731 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.72 -0.39 1.33e-13 Response to antipsychotic treatment; LUSC cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2524005 1.000 rs2524005 chr6:29899677 C/T cg05019905 chr6:29894831 HCG4P6 0.45 6.26 0.32 1.15e-9 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11686214 chr19:59084984 MZF1;LOC100131691 0.47 6.79 0.35 5.29e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg05863683 chr7:1912471 MAD1L1 0.31 6.11 0.32 2.77e-9 Bipolar disorder and schizophrenia; LUSC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg16586182 chr3:47516702 SCAP -0.5 -7.78 -0.39 9.14e-14 Colorectal cancer; LUSC trans rs7618314 0.504 rs2715694 chr3:108541143 C/T cg23542590 chr3:56717769 C3orf63 -0.56 -6.01 -0.31 4.77e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs7647973 1.000 rs62259947 chr3:49439924 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.48 -7.28 -0.37 2.47e-12 Menarche (age at onset); LUSC cis rs2625529 0.617 rs7175792 chr15:72431883 C/G cg16672083 chr15:72433130 SENP8 -0.49 -8.31 -0.41 2.46e-15 Red blood cell count; LUSC cis rs11190604 1.000 rs17746014 chr10:102315354 T/C cg16342193 chr10:102329863 NA -0.35 -6.14 -0.32 2.35e-9 Palmitoleic acid (16:1n-7) levels; LUSC trans rs9388451 0.807 rs1268070 chr6:126041164 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.56 -8.89 -0.44 3.89e-17 Brugada syndrome; LUSC cis rs9611519 0.780 rs1983631 chr22:41644074 C/T cg03806693 chr22:41940476 POLR3H -0.54 -7.87 -0.4 5.07e-14 Neuroticism; LUSC trans rs561341 1.000 rs1557731 chr17:30321567 T/G cg20587970 chr11:113659929 NA -1.16 -16.1 -0.66 1.42e-43 Hip circumference adjusted for BMI; LUSC cis rs2708977 0.901 rs6753667 chr2:97160382 G/A cg01950434 chr2:97203154 ARID5A -0.54 -8.15 -0.41 7.24e-15 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg03676636 chr4:99064102 C4orf37 0.27 5.84 0.3 1.24e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs6969780 1.000 rs73071548 chr7:27147430 A/G cg26364809 chr7:27145159 NA -0.61 -6.02 -0.31 4.7e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.46 6.55 0.34 2.21e-10 Gut microbiome composition (summer); LUSC cis rs6674970 1.000 rs6674970 chr1:151116279 C/T cg11822372 chr1:151115635 SEMA6C 0.57 8.92 0.44 3.16e-17 Childhood ear infection; LUSC cis rs9916302 0.706 rs597069 chr17:37458512 G/T cg07936489 chr17:37558343 FBXL20 0.83 10.41 0.5 3.52e-22 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.7 0.3 2.64e-8 Menopause (age at onset); LUSC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.78 0.63 2.16e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9457247 1.000 rs394522 chr6:167398071 A/C cg25258033 chr6:167368657 RNASET2 0.47 7.84 0.39 6.15e-14 Crohn's disease; LUSC cis rs3091242 0.900 rs1811832 chr1:25753565 G/A cg02931644 chr1:25747376 RHCE 0.38 6.91 0.35 2.53e-11 Erythrocyte sedimentation rate; LUSC cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs6545883 0.859 rs35760550 chr2:61603865 T/A cg15711740 chr2:61764176 XPO1 0.41 6.26 0.32 1.19e-9 Tuberculosis; LUSC cis rs939658 0.626 rs11636901 chr15:79446292 T/C cg17916960 chr15:79447300 NA -0.45 -8.75 -0.43 1.09e-16 Refractive error; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs4969178 0.622 rs4129767 chr17:76403984 G/A cg20026190 chr17:76395443 PGS1 0.34 5.83 0.3 1.28e-8 HDL cholesterol levels; LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.49 0.42 6.97e-16 Prudent dietary pattern; LUSC cis rs2797160 0.547 rs9388442 chr6:125972608 G/C cg05901451 chr6:126070800 HEY2 -0.41 -5.88 -0.31 9.89e-9 Endometrial cancer; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg11905131 chr22:24372483 LOC391322 0.43 5.84 0.3 1.23e-8 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs8060686 0.623 rs56303487 chr16:68029739 C/T cg27539214 chr16:67997921 SLC12A4 -0.42 -6.03 -0.31 4.33e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04020590 chr13:113978800 GRTP1 -0.39 -6.02 -0.31 4.6e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg06618935 chr21:46677482 NA -0.37 -7.54 -0.38 4.6e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.865 rs9994730 chr4:120381564 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.46 0.33 3.67e-10 Corneal astigmatism; LUSC cis rs56161922 1.000 rs72468035 chr1:207812405 C/T cg11752769 chr1:207818423 CR1L -0.69 -5.72 -0.3 2.31e-8 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg11871910 chr12:69753446 YEATS4 0.83 14.58 0.62 1.34e-37 Blood protein levels; LUSC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg13319975 chr6:146136371 FBXO30 -0.51 -7.58 -0.38 3.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs78366141 0.649 rs78959409 chr4:89659712 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.93 7.0 0.36 1.37e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs7615952 0.546 rs2979340 chr3:125341384 C/T cg07211511 chr3:129823064 LOC729375 -0.53 -6.08 -0.32 3.25e-9 Blood pressure (smoking interaction); LUSC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg24881330 chr22:46731750 TRMU 0.89 6.51 0.34 2.71e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9581857 0.685 rs9581856 chr13:28025615 G/C cg22138327 chr13:27999177 GTF3A 0.81 9.21 0.45 3.79e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg03146154 chr1:46216737 IPP -0.51 -7.73 -0.39 1.3e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg21782813 chr7:2030301 MAD1L1 0.53 9.27 0.45 2.38e-18 Bipolar disorder and schizophrenia; LUSC cis rs950776 0.647 rs495956 chr15:78869930 C/T cg06917634 chr15:78832804 PSMA4 -0.68 -10.99 -0.52 3.42e-24 Sudden cardiac arrest; LUSC cis rs7091068 0.518 rs4919436 chr10:95461475 C/T cg20715218 chr10:95462985 C10orf4 0.47 5.97 0.31 6.1e-9 Urinary tract infection frequency; LUSC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg17211192 chr8:82754475 SNX16 -0.61 -8.54 -0.42 4.94e-16 Diastolic blood pressure; LUSC cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg18252515 chr7:66147081 NA -1.23 -13.96 -0.61 3.38e-35 Gout; LUSC cis rs7173743 0.934 rs7168915 chr15:79128889 C/T cg00540400 chr15:79124168 NA 0.35 6.04 0.31 4.14e-9 Coronary artery disease; LUSC cis rs7572644 0.665 rs4420671 chr2:28039300 G/C cg27432699 chr2:27873401 GPN1 0.56 7.02 0.36 1.23e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9815354 0.857 rs9852020 chr3:41830206 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg23583168 chr7:148888333 NA -0.9 -16.74 -0.68 4.08e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs68170813 0.652 rs56949084 chr7:107157387 G/A cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs10779751 0.960 rs4845860 chr1:11324193 A/G cg08854313 chr1:11322531 MTOR 0.85 14.29 0.62 1.73e-36 Body mass index; LUSC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg15839431 chr19:19639596 YJEFN3 -0.41 -5.72 -0.3 2.43e-8 Tonsillectomy; LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg11645453 chr3:52864694 ITIH4 0.32 7.38 0.37 1.25e-12 Electroencephalogram traits; LUSC cis rs4975709 0.801 rs3797063 chr5:1881549 A/T cg15595755 chr5:1867978 NA 0.39 6.25 0.32 1.25e-9 Cardiovascular disease risk factors; LUSC cis rs3892630 0.588 rs2287881 chr19:33333155 A/G cg22980127 chr19:33182716 NUDT19 -0.91 -13.12 -0.58 5.25e-32 Red blood cell traits; LUSC cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.69 -0.34 9.53e-11 Monocyte percentage of white cells; LUSC cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.8e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg18512352 chr11:47633146 NA 0.47 9.44 0.46 6.79e-19 Subjective well-being; LUSC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg12412775 chr1:25698385 RHCE -0.29 -6.07 -0.32 3.44e-9 Erythrocyte sedimentation rate; LUSC cis rs2070433 1.000 rs2839306 chr21:47954219 G/T cg12379764 chr21:47803548 PCNT -0.76 -10.38 -0.49 4.56e-22 Lymphocyte counts; LUSC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg22800045 chr5:56110881 MAP3K1 0.46 5.99 0.31 5.41e-9 Coronary artery disease; LUSC cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg22509189 chr2:225307070 NA -0.48 -6.21 -0.32 1.59e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg26587870 chr6:27730563 NA -0.61 -6.04 -0.31 4.14e-9 Depression; LUSC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg26408565 chr15:76604113 ETFA -0.47 -7.49 -0.38 6.07e-13 Blood metabolite levels; LUSC cis rs62400317 0.859 rs10456546 chr6:45217424 C/T cg18551225 chr6:44695536 NA -0.46 -7.64 -0.39 2.28e-13 Total body bone mineral density; LUSC cis rs380904 0.519 rs10102146 chr8:144649156 G/A cg13399544 chr8:144649678 C8orf73 0.45 6.81 0.35 4.52e-11 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs8141529 0.732 rs5752798 chr22:29181868 A/G cg15103426 chr22:29168792 CCDC117 0.6 8.35 0.42 1.87e-15 Lymphocyte counts; LUSC cis rs35306767 0.714 rs12762955 chr10:1078782 A/C cg26597838 chr10:835615 NA 0.57 7.49 0.38 6.05e-13 Eosinophil percentage of granulocytes; LUSC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg06001716 chr17:41278141 BRCA1;NBR2 -0.36 -5.81 -0.3 1.43e-8 Menopause (age at onset); LUSC cis rs9341808 0.591 rs6454147 chr6:80916328 G/A cg08355045 chr6:80787529 NA 0.48 8.34 0.42 1.95e-15 Sitting height ratio; LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg07507251 chr3:52567010 NT5DC2 0.34 6.71 0.34 8.33e-11 Bipolar disorder; LUSC cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg17892150 chr10:133769511 PPP2R2D -0.67 -9.52 -0.46 3.57e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs6502050 0.805 rs9915071 chr17:80119138 T/C cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs981844 0.712 rs6855082 chr4:154754039 A/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.26 -0.32 1.16e-9 Response to statins (LDL cholesterol change); LUSC cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.22 0.56 1.26e-28 Motion sickness; LUSC cis rs796364 0.806 rs11689664 chr2:201099961 A/G cg23649088 chr2:200775458 C2orf69 -0.57 -6.8 -0.35 4.76e-11 Schizophrenia; LUSC cis rs59698941 0.943 rs41298946 chr5:132268390 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs6456156 0.565 rs12529238 chr6:167465576 G/A cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg05855489 chr10:104503620 C10orf26 -0.7 -10.01 -0.48 8.51e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7659604 0.521 rs4833235 chr4:122695136 C/A cg06713675 chr4:122721982 EXOSC9 0.38 6.07 0.32 3.41e-9 Type 2 diabetes; LUSC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg03433033 chr1:76189801 ACADM -0.76 -10.26 -0.49 1.16e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg05234568 chr11:5960015 NA 0.53 8.02 0.4 1.75e-14 DNA methylation (variation); LUSC cis rs950027 0.620 rs1049518 chr15:45653367 G/A cg04036182 chr15:45458818 NA 0.35 5.75 0.3 2.01e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs2486288 0.656 rs11632920 chr15:45551264 C/T cg04036182 chr15:45458818 NA -0.35 -5.74 -0.3 2.14e-8 Glomerular filtration rate; LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg16145915 chr7:1198662 ZFAND2A -0.53 -10.02 -0.48 7.92e-21 Longevity;Endometriosis; LUSC cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.55 0.42 4.57e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg16680214 chr1:154839983 KCNN3 -0.52 -9.76 -0.47 5.77e-20 Prostate cancer; LUSC cis rs8062405 0.755 rs62034325 chr16:28538640 A/G cg16576597 chr16:28551801 NUPR1 0.3 6.01 0.31 4.76e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2147959 0.941 rs7524236 chr1:228630395 C/T cg18477163 chr1:228402036 OBSCN 0.44 6.1 0.32 2.88e-9 Adult asthma; LUSC cis rs9788682 1.000 rs12441426 chr15:78812329 T/C cg18825076 chr15:78729989 IREB2 0.47 6.32 0.33 8.41e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs929354 0.772 rs6459741 chr7:157014553 G/T cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.74e-19 Body mass index; LUSC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 11.08 0.52 1.72e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7954584 0.531 rs6486781 chr12:122318985 A/C cg10207240 chr12:122356781 WDR66 0.46 6.52 0.34 2.55e-10 Mean corpuscular volume; LUSC cis rs2953145 0.568 rs2975752 chr2:241521327 A/G cg07929629 chr2:241523174 NA 0.62 10.62 0.5 6.62e-23 Bipolar disorder; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg11060661 chr22:24314208 DDT;DDTL 0.48 8.02 0.4 1.82e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6430585 0.583 rs7581814 chr2:136641593 C/G cg07169764 chr2:136633963 MCM6 -1.17 -17.95 -0.7 6.46e-51 Corneal structure; LUSC cis rs11252926 0.527 rs11252754 chr10:538637 G/A cg03684893 chr10:554711 DIP2C -0.45 -8.29 -0.41 2.82e-15 Psychosis in Alzheimer's disease; LUSC cis rs6582630 0.554 rs8189625 chr12:38401177 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.71e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg11494091 chr17:61959527 GH2 0.64 13.62 0.6 6.4e-34 Prudent dietary pattern; LUSC cis rs12474201 0.925 rs1058157 chr2:46988275 G/A cg06386533 chr2:46925753 SOCS5 0.72 10.63 0.5 6.14e-23 Height; LUSC cis rs9534288 1.000 rs9534288 chr13:46605441 T/C cg15192986 chr13:46630673 CPB2 -0.75 -11.81 -0.54 4.06e-27 Blood protein levels; LUSC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg25643088 chr3:52874325 TMEM110 -0.39 -5.84 -0.3 1.24e-8 Schizophrenia; LUSC cis rs12364620 1 rs12364620 chr11:68252123 T/G cg20283391 chr11:68216788 NA -0.61 -8.51 -0.42 5.97e-16 Total body bone mineral density (age 0-15); LUSC cis rs12586317 0.553 rs78124218 chr14:35570606 G/A cg16230307 chr14:35515116 FAM177A1 0.78 10.01 0.48 8.72e-21 Psoriasis; LUSC cis rs7267979 1.000 rs6107033 chr20:25363591 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -19.83 -0.74 2.2e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs59918340 0.728 rs59172574 chr8:142231945 C/G cg23750338 chr8:142222470 SLC45A4 0.58 11.26 0.52 3.68e-25 Immature fraction of reticulocytes; LUSC cis rs67366981 1.000 rs59262654 chr14:77712261 A/G cg22824376 chr14:77648248 TMEM63C 0.65 6.19 0.32 1.75e-9 Obsessive-compulsive symptoms; LUSC cis rs3106136 1.000 rs2632401 chr4:95147055 C/G cg11021082 chr4:95130006 SMARCAD1 0.34 6.03 0.31 4.29e-9 Capecitabine sensitivity; LUSC cis rs3760982 0.967 rs3760984 chr19:44286762 C/T cg11993925 chr19:44307056 LYPD5 0.28 6.28 0.33 1.03e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg03354898 chr7:1950403 MAD1L1 -0.33 -6.34 -0.33 7.4e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.49 7.63 0.39 2.46e-13 Prudent dietary pattern; LUSC trans rs7824557 0.510 rs2736297 chr8:11234885 C/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.37 -0.33 6.31e-10 Retinal vascular caliber; LUSC cis rs9517302 0.615 rs9517306 chr13:99097962 T/C cg22223119 chr13:99095684 FARP1 -0.68 -9.67 -0.47 1.2e-19 Obesity-related traits; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg18765753 chr7:1198926 ZFAND2A -0.4 -7.24 -0.37 3.12e-12 Longevity;Endometriosis; LUSC cis rs4474465 0.607 rs7930161 chr11:78268878 C/A cg27205649 chr11:78285834 NARS2 0.56 6.55 0.34 2.12e-10 Alzheimer's disease (survival time); LUSC cis rs748404 0.578 rs576557 chr15:43597737 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.61 9.48 0.46 4.9e-19 Lung cancer; LUSC trans rs9929218 1.000 rs7186084 chr16:68816260 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.7 10.09 0.48 4.34e-21 Colorectal cancer; LUSC cis rs17270561 0.609 rs1892246 chr6:25764408 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 6.99 0.36 1.48e-11 Iron status biomarkers; LUSC cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg06784218 chr1:46089804 CCDC17 0.53 10.53 0.5 1.41e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg13047869 chr3:10149882 C3orf24 -0.59 -7.93 -0.4 3.32e-14 Alzheimer's disease; LUSC cis rs2279817 0.818 rs11582250 chr1:17994234 G/A cg21791023 chr1:18019539 ARHGEF10L -0.47 -6.13 -0.32 2.51e-9 Neuroticism; LUSC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg16339924 chr4:17578868 LAP3 0.55 8.45 0.42 8.91e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs950169 0.922 rs11630760 chr15:85113337 G/T cg17173187 chr15:85201210 NMB 0.35 6.26 0.32 1.19e-9 Schizophrenia; LUSC cis rs992157 0.775 rs7559428 chr2:219150238 A/G cg00012203 chr2:219082015 ARPC2 -0.7 -11.58 -0.54 2.78e-26 Colorectal cancer; LUSC cis rs12310956 0.510 rs10844690 chr12:33854752 C/A cg06521331 chr12:34319734 NA -0.36 -5.88 -0.31 9.85e-9 Morning vs. evening chronotype; LUSC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg18240062 chr17:79603768 NPLOC4 0.59 10.09 0.48 4.43e-21 Eye color traits; LUSC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg00431813 chr7:1051703 C7orf50 0.36 5.83 0.3 1.31e-8 Longevity;Endometriosis; LUSC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg09877947 chr5:131593287 PDLIM4 0.45 7.14 0.36 5.84e-12 Breast cancer; LUSC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg06287003 chr12:125626642 AACS 0.37 6.35 0.33 6.89e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg18904891 chr8:8559673 CLDN23 0.53 7.51 0.38 5.61e-13 Obesity-related traits; LUSC cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs4654899 0.833 rs10916919 chr1:21317524 A/G cg02927042 chr1:21476669 EIF4G3 0.36 5.83 0.3 1.31e-8 Superior frontal gyrus grey matter volume; LUSC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg21782813 chr7:2030301 MAD1L1 0.45 7.34 0.37 1.68e-12 Schizophrenia; LUSC cis rs7618501 0.933 rs3811695 chr3:49761613 C/T cg13072238 chr3:49761600 GMPPB -0.38 -6.26 -0.32 1.19e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg09455208 chr3:40491958 NA 0.56 10.52 0.5 1.54e-22 Renal cell carcinoma; LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs4295623 0.531 rs2898295 chr8:11595969 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -7.96 -0.4 2.67e-14 Morning vs. evening chronotype; LUSC trans rs2243480 1.000 rs73142162 chr7:65374296 A/T cg10756647 chr7:56101905 PSPH 0.88 8.43 0.42 1.02e-15 Diabetic kidney disease; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg02951883 chr7:2050386 MAD1L1 -0.59 -11.17 -0.52 8.06e-25 Bipolar disorder and schizophrenia; LUSC cis rs9527 0.590 rs10509766 chr10:104926334 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.53 0.46 3.35e-19 Arsenic metabolism; LUSC cis rs9467711 0.559 rs2295593 chr6:26501768 C/T cg09904177 chr6:26538194 HMGN4 -0.7 -6.46 -0.33 3.79e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs7937682 0.602 rs11214036 chr11:111773169 C/T cg22437258 chr11:111473054 SIK2 0.43 5.68 0.3 2.96e-8 Primary sclerosing cholangitis; LUSC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs6712932 1.000 rs10170234 chr2:105841841 C/G cg26874229 chr2:105853672 NA -0.32 -5.76 -0.3 1.95e-8 Type 2 diabetes; LUSC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg03806693 chr22:41940476 POLR3H 0.97 14.02 0.61 1.89e-35 Vitiligo; LUSC cis rs6977660 0.882 rs7781975 chr7:19849629 A/G cg07541023 chr7:19748670 TWISTNB 0.5 5.8 0.3 1.53e-8 Thyroid stimulating hormone; LUSC cis rs11864453 0.793 rs7197453 chr16:72079127 G/C cg16558253 chr16:72132732 DHX38 -0.42 -6.4 -0.33 5.2e-10 Fibrinogen levels; LUSC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs10927875 0.619 rs2013019 chr1:16129320 T/C cg21385522 chr1:16154831 NA -0.61 -9.84 -0.47 3.1e-20 Dilated cardiomyopathy; LUSC cis rs4478137 0.501 rs6828820 chr4:164230540 C/T cg06758707 chr4:164254230 NPY1R -0.48 -6.67 -0.34 1.09e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg01368799 chr11:117014884 PAFAH1B2 0.52 6.86 0.35 3.28e-11 Blood protein levels; LUSC cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg06784218 chr1:46089804 CCDC17 0.49 9.69 0.47 9.94e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1371867 0.846 rs1788205 chr8:101306546 G/C cg00191853 chr8:101177733 SPAG1 -0.41 -6.59 -0.34 1.68e-10 Atrioventricular conduction; LUSC cis rs6504663 0.525 rs557 chr17:48563234 C/T cg03611598 chr17:48586076 MYCBPAP 0.47 5.92 0.31 8.01e-9 Visceral fat; LUSC cis rs7617773 0.780 rs11706277 chr3:48360433 A/G cg11946769 chr3:48343235 NME6 0.9 13.27 0.59 1.38e-32 Coronary artery disease; LUSC cis rs3857536 0.842 rs2188590 chr6:66939534 A/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs7474896 0.559 rs1208560 chr10:38221618 A/T cg25427524 chr10:38739819 LOC399744 0.43 5.8 0.3 1.54e-8 Obesity (extreme); LUSC cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg05340658 chr4:99064831 C4orf37 0.59 8.19 0.41 5.62e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg01657329 chr11:68192670 LRP5 -0.44 -7.11 -0.36 6.87e-12 Total body bone mineral density; LUSC cis rs1008375 0.900 rs13144986 chr4:17675019 C/A cg18681998 chr4:17616180 MED28 -0.87 -15.17 -0.64 6.53e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg16230307 chr14:35515116 FAM177A1 0.77 8.68 0.43 1.74e-16 Psoriasis; LUSC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22307029 chr19:49891270 CCDC155 0.67 9.43 0.46 7.02e-19 Multiple sclerosis; LUSC cis rs4664304 0.802 rs17830307 chr2:160871799 T/C cg03641300 chr2:160917029 PLA2R1 -0.37 -5.99 -0.31 5.52e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg00684032 chr4:1343700 KIAA1530 -0.38 -6.51 -0.34 2.7e-10 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17024643 chr1:214725274 PTPN14 0.43 6.46 0.33 3.81e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7937682 0.921 rs34584980 chr11:111441537 G/A cg18187862 chr3:45730750 SACM1L -0.53 -6.6 -0.34 1.57e-10 Primary sclerosing cholangitis; LUSC cis rs8072100 0.713 rs1912486 chr17:45515167 A/G cg08085267 chr17:45401833 C17orf57 -0.51 -7.3 -0.37 2.07e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4363385 0.719 rs6664823 chr1:152933424 A/C cg07796016 chr1:152779584 LCE1C -0.49 -6.99 -0.36 1.52e-11 Inflammatory skin disease; LUSC cis rs11112613 0.775 rs7299470 chr12:105961773 G/A cg03607813 chr12:105948248 NA 0.8 11.78 0.54 4.85e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs61931739 0.817 rs1687002 chr12:34170263 T/C cg13010199 chr12:38710504 ALG10B 0.42 6.76 0.35 6.11e-11 Morning vs. evening chronotype; LUSC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg01448562 chr3:133502909 NA -0.36 -5.69 -0.3 2.72e-8 Iron status biomarkers; LUSC cis rs12711979 0.509 rs10178286 chr2:3823821 A/G cg17052675 chr2:3827356 NA 0.82 18.82 0.72 2.22e-54 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.66 -0.3 3.23e-8 Life satisfaction; LUSC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg06494592 chr3:125709126 NA -0.49 -5.66 -0.3 3.27e-8 Blood pressure (smoking interaction); LUSC cis rs9650315 0.866 rs35587857 chr8:57167248 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.87 0.35 3.07e-11 Height; LUSC trans rs7824557 0.628 rs11250129 chr8:11202154 G/A cg15556689 chr8:8085844 FLJ10661 0.45 6.67 0.34 1.04e-10 Retinal vascular caliber; LUSC trans rs2797160 1.000 rs1739349 chr6:126014984 G/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.88 0.35 2.9e-11 Endometrial cancer; LUSC trans rs11098499 0.697 rs28655325 chr4:120372999 A/G cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs11955175 1.000 rs79575541 chr5:40672422 C/G cg05478818 chr5:40835740 RPL37 0.72 5.95 0.31 6.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs4423214 0.840 rs1123007 chr11:71185357 G/A cg05163923 chr11:71159392 DHCR7 -0.76 -9.76 -0.47 5.62e-20 Vitamin D levels; LUSC cis rs79149102 0.579 rs7168638 chr15:75280826 T/C cg17294928 chr15:75287854 SCAMP5 -0.7 -5.98 -0.31 5.73e-9 Lung cancer; LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg03579872 chr1:53393473 SCP2 -0.39 -5.87 -0.31 1.05e-8 Monocyte count; LUSC cis rs9788682 0.747 rs2656071 chr15:78745343 A/T cg18825076 chr15:78729989 IREB2 -0.48 -6.82 -0.35 4.3e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6545883 0.965 rs6718887 chr2:61727215 G/A cg15711740 chr2:61764176 XPO1 -0.47 -7.36 -0.37 1.43e-12 Tuberculosis; LUSC cis rs2762353 0.904 rs13197514 chr6:25785991 C/T cg03517284 chr6:25882590 NA 0.44 7.78 0.39 9.2e-14 Blood metabolite levels; LUSC cis rs10751667 0.666 rs11246357 chr11:963980 A/C ch.11.42038R chr11:967971 AP2A2 0.44 6.68 0.34 1.02e-10 Alzheimer's disease (late onset); LUSC cis rs4740619 0.619 rs1328280 chr9:16030903 C/T cg14451791 chr9:16040625 NA 0.36 7.02 0.36 1.22e-11 Body mass index; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg07167872 chr1:205819463 PM20D1 0.99 23.34 0.79 3.81e-72 Menarche (age at onset); LUSC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg17366294 chr4:99064904 C4orf37 0.6 10.63 0.5 6.42e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1997103 1.000 rs2177802 chr7:55410789 G/A cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg06454157 chr6:167490870 NA -0.25 -6.03 -0.31 4.28e-9 Crohn's disease; LUSC cis rs2046867 0.862 rs6766747 chr3:72856551 T/C cg25664220 chr3:72788482 NA -0.71 -11.88 -0.54 2.2e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2289583 0.517 rs2004278 chr15:75264363 C/T cg10253484 chr15:75165896 SCAMP2 0.43 5.8 0.3 1.56e-8 Systemic lupus erythematosus; LUSC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12681288 0.823 rs2701906 chr8:1003316 T/C cg04851639 chr8:1020857 NA -0.37 -7.78 -0.39 8.96e-14 Schizophrenia; LUSC cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg24692254 chr21:30365293 RNF160 -0.84 -15.65 -0.65 8.92e-42 Dental caries; LUSC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg07741184 chr6:167504864 NA -0.35 -6.42 -0.33 4.59e-10 Crohn's disease; LUSC cis rs765787 0.530 rs12592055 chr15:45514477 C/T cg24006582 chr15:45444508 DUOX1 0.65 9.45 0.46 6.3e-19 Uric acid levels; LUSC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg16545954 chr1:2118288 C1orf86 0.37 7.19 0.37 4.18e-12 Height; LUSC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg19592336 chr6:28129416 ZNF389 0.47 6.19 0.32 1.75e-9 Depression; LUSC cis rs7072216 0.763 rs9787550 chr10:100169051 C/T cg26618903 chr10:100175079 PYROXD2 -0.48 -8.79 -0.43 7.99e-17 Metabolite levels; LUSC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg08439880 chr3:133502540 NA -0.35 -6.34 -0.33 7.26e-10 Iron status biomarkers; LUSC cis rs35883536 0.587 rs2809799 chr1:101036516 A/G cg06223162 chr1:101003688 GPR88 0.49 9.27 0.45 2.44e-18 Monocyte count; LUSC cis rs9457247 0.561 rs916331 chr6:167470559 T/G cg25258033 chr6:167368657 RNASET2 0.45 6.81 0.35 4.5e-11 Crohn's disease; LUSC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg05425664 chr17:57184151 TRIM37 -0.59 -9.19 -0.45 4.42e-18 Intelligence (multi-trait analysis); LUSC cis rs6733011 0.581 rs4851162 chr2:99466659 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.68 -0.3 2.92e-8 Bipolar disorder; LUSC cis rs478304 0.651 rs78412025 chr11:65495696 T/C cg10604040 chr11:65559109 OVOL1 0.31 5.72 0.3 2.34e-8 Acne (severe); LUSC cis rs7615952 0.609 rs13088451 chr3:125553499 G/C cg05084668 chr3:125655381 ALG1L -0.62 -8.99 -0.44 1.88e-17 Blood pressure (smoking interaction); LUSC cis rs1580019 0.961 rs3801328 chr7:32496930 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.86 0.54 2.63e-27 Cognitive ability; LUSC cis rs28374715 0.662 rs72737792 chr15:41515589 G/C cg18705301 chr15:41695430 NDUFAF1 -0.82 -14.22 -0.61 3.17e-36 Ulcerative colitis; LUSC cis rs3772130 1.000 rs11721318 chr3:121429485 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.64 9.28 0.45 2.14e-18 Cognitive performance; LUSC cis rs9309473 0.519 rs1083922 chr2:73704003 A/G cg20560298 chr2:73613845 ALMS1 0.44 6.78 0.35 5.59e-11 Metabolite levels; LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC cis rs11122272 0.701 rs971533 chr1:231522097 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg00933542 chr6:150070202 PCMT1 0.3 6.0 0.31 5.27e-9 Lung cancer; LUSC trans rs1908814 0.516 rs4367597 chr8:11793529 C/T cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.64e-16 Neuroticism; LUSC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg03806693 chr22:41940476 POLR3H 0.99 13.72 0.6 2.7200000000000002e-34 Vitiligo; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg14004847 chr7:1930337 MAD1L1 -0.5 -7.52 -0.38 4.96e-13 Bipolar disorder and schizophrenia; LUSC trans rs1945213 0.694 rs12422168 chr11:55866840 A/G cg15704280 chr7:45808275 SEPT13 0.74 8.4 0.42 1.26e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs6964587 1.000 rs11981461 chr7:91692662 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg15448220 chr1:150897856 SETDB1 0.38 5.66 0.3 3.19e-8 Tonsillectomy; LUSC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg20135002 chr11:47629003 NA 0.48 7.47 0.38 7.13e-13 Subjective well-being; LUSC cis rs308403 0.608 rs309362 chr4:123658154 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.82 10.68 0.5 4.34e-23 Blood protein levels; LUSC cis rs7843479 0.601 rs4872209 chr8:21848832 A/T cg17168535 chr8:21777572 XPO7 0.82 14.88 0.63 9.25e-39 Mean corpuscular volume; LUSC cis rs7681440 0.626 rs2289515 chr4:90816790 T/A cg20003494 chr4:90757398 SNCA -0.35 -5.85 -0.3 1.16e-8 Dementia with Lewy bodies; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg10150615 chr22:24372951 LOC391322 0.42 6.92 0.35 2.29e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg14004847 chr7:1930337 MAD1L1 -0.57 -8.65 -0.43 2.26e-16 Bipolar disorder and schizophrenia; LUSC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg00343986 chr7:65444356 GUSB 0.44 6.72 0.35 7.81e-11 Aortic root size; LUSC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg26513180 chr16:89883248 FANCA -0.58 -8.75 -0.43 1.05e-16 Vitiligo; LUSC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.19 0.49 2.08e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2235544 0.565 rs928443 chr1:54473516 C/T cg25741118 chr1:54482237 LDLRAD1 0.29 6.09 0.32 3.07e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs1609391 0.567 rs835633 chr3:136676496 T/C cg12473912 chr3:136751656 NA 0.38 6.68 0.34 1e-10 Neuroticism; LUSC cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg03676636 chr4:99064102 C4orf37 0.36 8.01 0.4 1.97e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6545883 0.860 rs6545847 chr2:61445333 C/T cg15711740 chr2:61764176 XPO1 0.45 6.96 0.36 1.85e-11 Tuberculosis; LUSC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg16545954 chr1:2118288 C1orf86 0.38 7.45 0.38 8.29e-13 Height; LUSC trans rs61931739 0.534 rs10844774 chr12:34166764 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.49 0.42 6.68e-16 Morning vs. evening chronotype; LUSC cis rs9650657 0.707 rs6984744 chr8:10616265 A/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.08 -0.32 3.26e-9 Neuroticism; LUSC cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg26373071 chr5:1325741 CLPTM1L 0.44 8.18 0.41 5.88e-15 Lung cancer; LUSC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg20712883 chr12:51590929 POU6F1 0.46 6.65 0.34 1.19e-10 Cisplatin-induced ototoxicity; LUSC cis rs17253792 0.822 rs76819679 chr14:56134672 C/G cg01858014 chr14:56050164 KTN1 -0.77 -6.57 -0.34 1.95e-10 Putamen volume; LUSC cis rs7512552 0.803 rs11582423 chr1:150493925 C/G cg15654264 chr1:150340011 RPRD2 0.59 9.52 0.46 3.53e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs3859192 0.537 rs12309 chr17:38175462 C/T cg17467752 chr17:38218738 THRA -0.51 -7.2 -0.37 4.05e-12 White blood cell count; LUSC cis rs1790761 0.554 rs3758938 chr11:67402362 T/G cg14500267 chr11:67383377 NA -0.35 -6.13 -0.32 2.41e-9 Mean corpuscular volume; LUSC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs45509595 0.841 rs200501 chr6:27788942 C/T cg01620082 chr3:125678407 NA -0.69 -7.05 -0.36 1.06e-11 Breast cancer; LUSC cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg03060546 chr3:49711283 APEH -0.69 -10.24 -0.49 1.42e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg19719311 chr1:51443992 NA 0.34 6.39 0.33 5.65e-10 Metabolite levels (Pyroglutamine); LUSC cis rs4689388 0.610 rs4328980 chr4:6281756 A/G cg25554036 chr4:6271136 WFS1 0.51 9.11 0.45 7.51e-18 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg08213375 chr14:104286397 PPP1R13B 0.45 8.18 0.41 6.17e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs7726839 0.540 rs72705102 chr5:659437 T/C cg25482853 chr8:67687455 SGK3 1.1 15.5 0.65 3.27e-41 Obesity-related traits; LUSC cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg09469691 chr10:81107165 PPIF 0.63 9.21 0.45 3.65e-18 Height; LUSC cis rs2224391 0.628 rs2753238 chr6:5252795 A/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.66 -0.34 1.15e-10 Height; LUSC cis rs6977660 0.714 rs728156 chr7:19826309 G/C cg07541023 chr7:19748670 TWISTNB 0.6 6.3 0.33 9.45e-10 Thyroid stimulating hormone; LUSC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg22029157 chr1:209979665 IRF6 0.72 8.9 0.44 3.5e-17 Cleft lip with or without cleft palate; LUSC cis rs6430585 1.000 rs6732236 chr2:136501509 T/G cg07169764 chr2:136633963 MCM6 0.89 12.05 0.55 5.37e-28 Corneal structure; LUSC cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg08807101 chr21:30365312 RNF160 0.72 11.46 0.53 7.28e-26 Selective IgA deficiency; LUSC cis rs1559088 0.842 rs12977993 chr19:33580453 T/A cg03563238 chr19:33554763 RHPN2 -0.39 -6.24 -0.32 1.3e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.47 6.29 0.33 9.83e-10 Renal function-related traits (BUN); LUSC cis rs12210905 1.000 rs72843613 chr6:27138467 G/A cg11502198 chr6:26597334 ABT1 -0.79 -5.66 -0.3 3.22e-8 Hip circumference adjusted for BMI; LUSC cis rs7615952 0.800 rs12489350 chr3:125644116 T/C cg05084668 chr3:125655381 ALG1L -0.76 -11.47 -0.53 6.5e-26 Blood pressure (smoking interaction); LUSC cis rs9807989 0.765 rs6751977 chr2:102967430 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.85 0.3 1.19e-8 Asthma; LUSC cis rs934734 0.967 rs1866051 chr2:65602149 T/C cg08085232 chr2:65598271 SPRED2 -0.37 -5.81 -0.3 1.49e-8 Rheumatoid arthritis; LUSC cis rs10493773 0.748 rs6576784 chr1:86149476 G/A cg17807903 chr1:86174739 ZNHIT6 -0.49 -11.77 -0.54 5.48e-27 Urate levels in overweight individuals; LUSC cis rs2346177 0.844 rs4953365 chr2:46644946 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.51 -7.76 -0.39 1.07e-13 HDL cholesterol; LUSC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg24110177 chr3:50126178 RBM5 0.66 11.46 0.53 7.41e-26 Body mass index; LUSC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg26408565 chr15:76604113 ETFA -0.45 -7.01 -0.36 1.31e-11 Blood metabolite levels; LUSC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg11301795 chr4:187892539 NA -0.8 -15.5 -0.65 3.24e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg14552801 chr7:65878734 NA -0.37 -5.87 -0.31 1.08e-8 Aortic root size; LUSC cis rs2486288 0.656 rs11854325 chr15:45548959 T/C cg09092052 chr15:45571596 NA 0.46 6.42 0.33 4.63e-10 Glomerular filtration rate; LUSC cis rs9677476 0.909 rs13408391 chr2:232124127 G/T cg07929768 chr2:232055508 NA 0.34 6.28 0.33 1.04e-9 Food antigen IgG levels; LUSC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg26769984 chr7:1090371 C7orf50 0.56 7.84 0.39 6.14e-14 Bronchopulmonary dysplasia; LUSC cis rs1577917 0.958 rs13207173 chr6:86457522 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.82 -0.43 6.39e-17 Response to antipsychotic treatment; LUSC cis rs7512552 0.768 rs7517441 chr1:150283643 A/T cg15654264 chr1:150340011 RPRD2 -0.65 -11.03 -0.52 2.44e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg07343612 chr16:622815 PIGQ -0.78 -13.43 -0.59 3.49e-33 Height; LUSC cis rs16854884 0.586 rs7639366 chr3:143752034 T/G cg06585982 chr3:143692056 C3orf58 0.52 8.27 0.41 3.23e-15 Economic and political preferences (feminism/equality); LUSC cis rs11630290 0.702 rs73444597 chr15:64126503 C/T cg12036633 chr15:63758958 NA -0.57 -6.32 -0.33 8.52e-10 Iris characteristics; LUSC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.73 -0.35 7.23e-11 Mean platelet volume; LUSC cis rs6598955 0.724 rs12732295 chr1:26602251 C/T cg00852783 chr1:26633632 UBXN11 0.49 8.68 0.43 1.76e-16 Obesity-related traits; LUSC cis rs9300255 0.537 rs1727334 chr12:123714236 A/G cg00376283 chr12:123451042 ABCB9 0.65 8.3 0.41 2.63e-15 Neutrophil percentage of white cells; LUSC cis rs921968 0.541 rs667251 chr2:219384384 C/G cg02176678 chr2:219576539 TTLL4 0.74 14.38 0.62 8e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs9527 0.545 rs12784384 chr10:104957594 G/C cg04362960 chr10:104952993 NT5C2 0.61 9.81 0.47 3.95e-20 Arsenic metabolism; LUSC cis rs9399135 0.967 rs1854865 chr6:135360300 C/G cg24558204 chr6:135376177 HBS1L 0.57 8.77 0.43 9.29e-17 Red blood cell count; LUSC trans rs72674100 1.000 rs28523751 chr4:97964750 T/A cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6061231 0.740 rs11698650 chr20:60958374 A/T cg24112000 chr20:60950667 NA -0.41 -8.04 -0.4 1.58e-14 Colorectal cancer; LUSC cis rs4664304 0.770 rs55860731 chr2:160875437 C/T cg03641300 chr2:160917029 PLA2R1 -0.36 -5.89 -0.31 9.46e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs55794721 0.509 rs12027135 chr1:25775733 A/T cg20684491 chr1:25596433 NA 0.39 6.1 0.32 2.88e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs11031096 0.503 rs10835604 chr11:4109709 A/T cg18678763 chr11:4115507 RRM1 -0.51 -6.86 -0.35 3.43e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.56 8.22 0.41 4.5e-15 Hip circumference adjusted for BMI; LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs4319547 0.626 rs12423420 chr12:122938466 G/A cg23029597 chr12:123009494 RSRC2 -0.67 -8.73 -0.43 1.21e-16 Body mass index; LUSC cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg00409905 chr10:38381863 ZNF37A -0.33 -5.72 -0.3 2.37e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7474896 1.000 rs11011339 chr10:37996346 C/A cg25427524 chr10:38739819 LOC399744 -0.51 -5.77 -0.3 1.8e-8 Obesity (extreme); LUSC cis rs6951245 0.572 rs73265911 chr7:1055363 G/A cg24642844 chr7:1081250 C7orf50 -0.58 -5.84 -0.3 1.23e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.48 7.51 0.38 5.43e-13 Prudent dietary pattern; LUSC cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg15423357 chr2:25149977 NA -0.44 -9.31 -0.45 1.71e-18 Body mass index in non-asthmatics; LUSC cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg08999081 chr20:33150536 PIGU -0.4 -7.47 -0.38 7.17e-13 Coronary artery disease; LUSC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg11062466 chr8:58055876 NA 0.67 7.7 0.39 1.53e-13 Developmental language disorder (linguistic errors); LUSC cis rs7246967 0.673 rs8102172 chr19:22870019 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs11153730 0.503 rs283045 chr6:118628476 C/G cg21191810 chr6:118973309 C6orf204 0.34 5.83 0.3 1.32e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg08859206 chr1:53392774 SCP2 -0.56 -9.93 -0.48 1.55e-20 Monocyte count; LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg03188948 chr7:1209495 NA 0.66 7.09 0.36 8.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg03351412 chr1:154909251 PMVK 0.54 8.32 0.41 2.24e-15 Prostate cancer; LUSC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg03526776 chr6:41159608 TREML2 -0.45 -8.71 -0.43 1.48e-16 Alzheimer's disease (late onset); LUSC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg22166914 chr1:53195759 ZYG11B 0.68 11.6 0.54 2.19e-26 Monocyte count; LUSC cis rs3770081 1.000 rs3770087 chr2:86267068 T/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.8 -5.95 -0.31 6.7e-9 Facial emotion recognition (sad faces); LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7568458 0.660 rs6722691 chr2:85758352 C/T cg17127132 chr2:85788382 GGCX 0.41 5.89 0.31 9.31e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg21984481 chr17:79567631 NPLOC4 0.74 15.59 0.65 1.42e-41 Eye color traits; LUSC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg15649852 chr7:65879115 NA -0.43 -5.81 -0.3 1.48e-8 Aortic root size; LUSC cis rs698813 0.604 rs1988663 chr2:44492753 C/T cg00619915 chr2:44497795 NA -0.54 -7.48 -0.38 6.57e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs7828089 0.935 rs1568569 chr8:22249943 T/G cg12081754 chr8:22256438 SLC39A14 0.62 9.64 0.47 1.46e-19 Verbal declarative memory; LUSC trans rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.87 0.35 3.2e-11 Endometrial cancer; LUSC cis rs11583043 0.575 rs12759611 chr1:101587145 T/G cg11406453 chr1:101602562 NA -0.4 -6.82 -0.35 4.29e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs12101261 0.536 rs2371463 chr14:81457788 G/A cg06600135 chr14:81408086 NA 0.46 6.96 0.36 1.79e-11 Graves' disease; LUSC cis rs9837602 1.000 rs7627991 chr3:99808338 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.51 6.28 0.32 1.08e-9 Breast cancer; LUSC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.99 -0.4 2.17e-14 Mean platelet volume; LUSC cis rs614226 0.872 rs12307148 chr12:120903179 T/C cg01236616 chr12:121019343 POP5 -1.33 -21.02 -0.75 4.35e-63 Type 1 diabetes nephropathy; LUSC cis rs4704187 0.687 rs4389672 chr5:74368642 G/T cg03227963 chr5:74354835 NA 0.33 7.23 0.37 3.26e-12 Response to amphetamines; LUSC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg00409905 chr10:38381863 ZNF37A -0.39 -6.63 -0.34 1.36e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9308433 0.529 rs17022608 chr1:214500907 A/C cg06198575 chr1:214491504 SMYD2 0.45 6.87 0.35 3.11e-11 IgG glycosylation; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11060661 chr22:24314208 DDT;DDTL 0.4 6.7 0.34 8.98e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg07701084 chr6:150067640 NUP43 0.57 8.87 0.44 4.63e-17 Lung cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03630847 chr5:172385878 LOC100268168;RPL26L1 0.74 6.01 0.31 4.81e-9 Cognitive performance; LUSC cis rs9886651 0.935 rs4582525 chr8:128800947 A/G cg07795030 chr8:128802207 NA -0.34 -6.08 -0.32 3.35e-9 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC trans rs61931739 0.635 rs1825746 chr12:33939984 C/T cg13010199 chr12:38710504 ALG10B 0.4 6.05 0.31 3.88e-9 Morning vs. evening chronotype; LUSC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg02569458 chr12:86230093 RASSF9 0.52 8.57 0.42 3.81e-16 Major depressive disorder; LUSC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.32 -0.41 2.23e-15 Intelligence (multi-trait analysis); LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg26855724 chr1:75198818 TYW3;CRYZ 0.46 7.42 0.38 9.53e-13 Resistin levels; LUSC cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg16745616 chr19:8428856 ANGPTL4 -0.4 -6.03 -0.31 4.41e-9 HDL cholesterol; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01794563 chr14:102430985 DYNC1H1 -0.39 -6.01 -0.31 4.85e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs34638657 0.732 rs12597171 chr16:82200119 A/G cg09439754 chr16:82129088 HSD17B2 0.35 5.76 0.3 1.87e-8 Lung adenocarcinoma; LUSC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg12756686 chr19:29218302 NA 0.59 6.86 0.35 3.26e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg21385522 chr1:16154831 NA -0.73 -11.46 -0.53 7.13e-26 Dilated cardiomyopathy; LUSC cis rs12579753 0.871 rs12822050 chr12:82183041 C/T cg21231944 chr12:82153410 PPFIA2 -0.37 -5.7 -0.3 2.63e-8 Resting heart rate; LUSC cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg18477163 chr1:228402036 OBSCN -0.57 -10.59 -0.5 8.66e-23 Diastolic blood pressure; LUSC cis rs62400317 0.859 rs10948212 chr6:45156933 A/C cg18551225 chr6:44695536 NA -0.45 -7.22 -0.37 3.47e-12 Total body bone mineral density; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg11965913 chr1:205819406 PM20D1 0.88 16.95 0.68 5.97e-47 Menarche (age at onset); LUSC cis rs28580297 1 rs28580297 chr4:119427957 C/G cg02775129 chr4:119771670 NA -0.56 -6.06 -0.31 3.71e-9 Body mass index; LUSC trans rs6952808 0.692 rs10950473 chr7:1999453 G/A cg04565464 chr8:145669602 NFKBIL2 0.37 6.05 0.31 3.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs35306767 0.623 rs36062650 chr10:1142571 T/C cg20503657 chr10:835505 NA 0.46 6.03 0.31 4.34e-9 Eosinophil percentage of granulocytes; LUSC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg16325326 chr1:53192061 ZYG11B -0.92 -18.08 -0.7 2.05e-51 Monocyte count; LUSC cis rs7191439 0.858 rs11076701 chr16:88774525 A/G cg27087555 chr16:88793112 FAM38A -1.42 -13.09 -0.58 7.12e-32 Plateletcrit; LUSC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg19812747 chr11:111475976 SIK2 -0.55 -8.14 -0.41 7.93e-15 Primary sclerosing cholangitis; LUSC trans rs7726839 0.540 rs72703078 chr5:594987 A/C cg25482853 chr8:67687455 SGK3 1.12 16.14 0.66 1.01e-43 Obesity-related traits; LUSC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg22903471 chr2:27725779 GCKR -0.4 -6.84 -0.35 3.67e-11 Total body bone mineral density; LUSC cis rs686320 1.000 rs679643 chr11:65250590 C/A cg21890820 chr11:65308645 LTBP3 0.77 7.76 0.39 1.05e-13 Hip circumference adjusted for BMI; LUSC cis rs1419980 0.673 rs10772553 chr12:7768089 G/A cg10578777 chr12:7781093 NA -0.57 -6.25 -0.32 1.27e-9 HDL cholesterol levels; LUSC cis rs35146811 0.735 rs1727133 chr7:99812870 C/T cg19116668 chr7:99932089 PMS2L1 0.35 6.12 0.32 2.68e-9 Coronary artery disease; LUSC cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg00012203 chr2:219082015 ARPC2 -0.7 -11.44 -0.53 8.34e-26 Colorectal cancer; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.52e-9 Menopause (age at onset); LUSC cis rs2456568 0.570 rs1827932 chr11:93663319 A/T cg17595323 chr11:93583763 C11orf90 -0.31 -5.78 -0.3 1.75e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg14829155 chr15:31115871 NA 0.71 11.03 0.52 2.47e-24 Huntington's disease progression; LUSC cis rs9644630 0.932 rs4273861 chr8:19352703 C/T cg01280390 chr8:19363452 CSGALNACT1 0.37 6.96 0.36 1.84e-11 Oropharynx cancer; LUSC trans rs4720118 0.967 rs4723288 chr7:33487086 C/T cg18659248 chr10:3679062 NA -0.35 -6.03 -0.31 4.28e-9 Leprosy; LUSC cis rs2933343 0.679 rs1091938 chr3:128637025 T/C cg11901034 chr3:128598214 ACAD9 -0.39 -6.03 -0.31 4.3e-9 IgG glycosylation; LUSC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg08219700 chr8:58056026 NA 0.5 6.18 0.32 1.84e-9 Developmental language disorder (linguistic errors); LUSC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg11247378 chr22:39784982 NA -0.65 -13.06 -0.58 8.8e-32 Intelligence (multi-trait analysis); LUSC cis rs2486288 0.656 rs11632724 chr15:45550791 G/A cg09092052 chr15:45571596 NA 0.46 6.36 0.33 6.52e-10 Glomerular filtration rate; LUSC cis rs7980687 0.627 rs1727325 chr12:123698332 G/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Height;Educational attainment;Head circumference (infant); LUSC cis rs3771570 1.000 rs73004354 chr2:242356239 G/T cg21155796 chr2:242212141 HDLBP 0.61 6.57 0.34 1.9e-10 Prostate cancer; LUSC cis rs7258465 1.000 rs271623 chr19:18628947 A/G cg06462663 chr19:18546047 ISYNA1 0.45 7.63 0.39 2.54e-13 Breast cancer; LUSC cis rs3764021 0.870 rs10743819 chr12:9876768 A/C cg20894963 chr12:9885564 CLECL1 0.35 7.1 0.36 7.57e-12 Type 1 diabetes; LUSC cis rs868036 0.681 rs28670272 chr15:68109907 C/T cg08079166 chr15:68083412 MAP2K5 -0.4 -7.33 -0.37 1.78e-12 Restless legs syndrome; LUSC cis rs7937682 0.924 rs6589244 chr11:111534333 T/C cg09085632 chr11:111637200 PPP2R1B -1.09 -17.12 -0.68 1.32e-47 Primary sclerosing cholangitis; LUSC cis rs6754311 0.731 rs6719488 chr2:136575199 G/T cg25344623 chr2:136566232 LCT 0.38 5.73 0.3 2.27e-8 Mosquito bite size; LUSC cis rs4917833 0.789 rs11189618 chr10:100219519 G/A cg19043522 chr10:100227446 HPSE2 0.4 5.71 0.3 2.53e-8 Pediatric bone mineral density (femoral neck); LUSC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 9.84 0.47 3.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs870825 0.616 rs4519838 chr4:185628457 A/G cg04058563 chr4:185651563 MLF1IP 0.88 13.14 0.58 4.44e-32 Blood protein levels; LUSC cis rs11997175 0.715 rs7012923 chr8:33630937 A/C ch.8.33884649F chr8:33765107 NA 0.41 6.65 0.34 1.19e-10 Body mass index; LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg00166722 chr3:10149974 C3orf24 0.6 8.2 0.41 5.37e-15 Alzheimer's disease; LUSC trans rs11098499 0.954 rs10024844 chr4:120311528 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg15423357 chr2:25149977 NA 0.44 8.97 0.44 2.11e-17 Body mass index; LUSC cis rs240768 1.000 rs240157 chr6:101062677 T/C cg12253828 chr6:101329408 ASCC3 0.83 5.73 0.3 2.27e-8 Economic and political preferences (immigration/crime); LUSC cis rs2933343 0.729 rs813945 chr3:128660937 A/G cg11901034 chr3:128598214 ACAD9 -0.39 -6.26 -0.32 1.18e-9 IgG glycosylation; LUSC cis rs939574 1.000 rs45488900 chr2:220116509 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.09 8.72 0.43 1.31e-16 Platelet distribution width; LUSC cis rs6558174 0.965 rs4072394 chr8:22490800 C/T cg03733263 chr8:22462867 KIAA1967 0.45 6.01 0.31 4.74e-9 Breast cancer; LUSC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg07424592 chr7:64974309 NA -0.64 -5.73 -0.3 2.24e-8 Diabetic kidney disease; LUSC trans rs877282 0.947 rs4133015 chr10:774131 T/C cg13042288 chr15:90349979 ANPEP -0.48 -7.01 -0.36 1.31e-11 Uric acid levels; LUSC cis rs3008870 0.755 rs2815364 chr1:67498384 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.51 0.56 1.01e-29 Lymphocyte percentage of white cells; LUSC cis rs2857891 0.817 rs2638095 chr11:6979915 C/T cg04053776 chr11:6947353 ZNF215 0.42 5.78 0.3 1.72e-8 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs4332037 0.624 rs11766944 chr7:1888051 G/A cg10840412 chr1:235813424 GNG4 0.47 6.02 0.31 4.71e-9 Bipolar disorder; LUSC cis rs4664308 1.000 rs17831251 chr2:160914156 C/T cg03641300 chr2:160917029 PLA2R1 -0.68 -11.35 -0.53 1.8e-25 Idiopathic membranous nephropathy; LUSC trans rs2243480 0.522 rs73150635 chr7:65972490 C/T cg10756647 chr7:56101905 PSPH 1.01 6.53 0.34 2.51e-10 Diabetic kidney disease; LUSC cis rs3126085 0.935 rs7537637 chr1:152223335 T/A cg26876637 chr1:152193138 HRNR 0.44 6.2 0.32 1.7e-9 Atopic dermatitis; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg21280719 chr6:42927975 GNMT -0.32 -7.82 -0.39 7.14e-14 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17650050 chr22:19419470 HIRA;MRPL40 -0.43 -6.65 -0.34 1.17e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7178572 0.568 rs11857294 chr15:77596725 C/T cg22256960 chr15:77711686 NA -0.51 -8.04 -0.4 1.63e-14 Type 2 diabetes; LUSC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg09021430 chr5:549028 NA -0.57 -8.38 -0.42 1.51e-15 Obesity-related traits; LUSC cis rs7746199 0.736 rs34573979 chr6:27480526 C/T cg26958806 chr6:27640298 NA 0.8 6.56 0.34 2.04e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs62380364 0.602 rs650702 chr5:88055313 G/A cg22951263 chr5:87985283 NA -0.46 -7.53 -0.38 4.89e-13 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs10883511 chr10:102299407 A/G cg23241863 chr10:102295624 HIF1AN 0.48 5.91 0.31 8.23e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg24060327 chr5:131705240 SLC22A5 -0.37 -6.0 -0.31 5.14e-9 Blood metabolite levels; LUSC trans rs12579753 0.917 rs12372724 chr12:82193628 C/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs67072384 0.901 rs67288233 chr11:72458361 G/A cg04827223 chr11:72435913 ARAP1 -0.74 -6.39 -0.33 5.61e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9341808 0.519 rs4446525 chr6:81024053 C/T cg08355045 chr6:80787529 NA -0.42 -7.15 -0.36 5.59e-12 Sitting height ratio; LUSC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg17724175 chr1:150552817 MCL1 -0.37 -6.79 -0.35 5.14e-11 Tonsillectomy; LUSC trans rs8072100 0.935 rs4793978 chr17:45698175 G/A cg04995722 chr7:26192034 NFE2L3 0.37 6.17 0.32 1.97e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12618769 1.000 rs55934348 chr2:99246885 T/C cg10123293 chr2:99228465 UNC50 0.42 5.75 0.3 1.96e-8 Bipolar disorder; LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -11.93 -0.55 1.4e-27 Platelet count; LUSC trans rs877282 1.000 rs12779159 chr10:772143 T/C cg22713356 chr15:30763199 NA 1.11 15.45 0.65 5.38e-41 Uric acid levels; LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg06600287 chr1:53387719 ECHDC2 -0.28 -5.73 -0.3 2.26e-8 Monocyte count; LUSC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg17376030 chr22:41985996 PMM1 0.46 5.85 0.31 1.15e-8 Vitiligo; LUSC cis rs9527 0.615 rs7096452 chr10:104736563 G/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.6 -0.34 1.57e-10 Arsenic metabolism; LUSC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.39 0.53 1.25e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs17270561 0.697 rs9366633 chr6:25838054 A/G cg16482183 chr6:26056742 HIST1H1C 0.56 7.89 0.4 4.21e-14 Iron status biomarkers; LUSC cis rs2742234 0.541 rs61845684 chr10:43744983 T/C cg07801480 chr10:43725741 RASGEF1A -0.39 -5.66 -0.3 3.26e-8 Hirschsprung disease; LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg26314531 chr2:26401878 FAM59B -0.7 -9.79 -0.47 4.64e-20 Gut microbiome composition (summer); LUSC cis rs2742234 0.554 rs1270015 chr10:43698240 G/T cg15436174 chr10:43711423 RASGEF1A 0.44 6.97 0.36 1.68e-11 Hirschsprung disease; LUSC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg24503407 chr1:205819492 PM20D1 0.42 5.65 0.3 3.51e-8 White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.76 -13.74 -0.6 2.24e-34 Intelligence (multi-trait analysis); LUSC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11644478 chr21:40555479 PSMG1 -0.62 -9.7 -0.47 9.15e-20 Menarche (age at onset); LUSC cis rs12545109 0.879 rs2576580 chr8:57365828 G/C cg09654669 chr8:57350985 NA -0.57 -7.46 -0.38 7.7e-13 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07135601 chr12:110906630 GPN3;C12orf24 -0.42 -6.26 -0.32 1.21e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg06028605 chr16:24865363 SLC5A11 0.59 8.58 0.42 3.75e-16 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs3087591 0.708 rs2854319 chr17:29694054 G/C cg24425628 chr17:29625626 OMG;NF1 0.49 7.16 0.36 5.13e-12 Hip circumference; LUSC cis rs11098499 1.000 rs13435802 chr4:120177960 A/T cg09307838 chr4:120376055 NA -0.67 -9.79 -0.47 4.56e-20 Corneal astigmatism; LUSC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg11871910 chr12:69753446 YEATS4 -0.92 -17.48 -0.69 4.62e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg22467129 chr15:76604101 ETFA 0.44 6.98 0.36 1.62e-11 Blood metabolite levels; LUSC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg05861140 chr6:150128134 PCMT1 -0.45 -7.17 -0.37 4.83e-12 Lung cancer; LUSC cis rs921968 0.541 rs636723 chr2:219373197 A/G cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC trans rs62238980 0.614 rs4820062 chr22:32392437 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs11734570 0.581 rs4461531 chr4:38603576 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.48 6.03 0.31 4.41e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg15557168 chr22:42548783 NA -0.47 -7.31 -0.37 2.03e-12 Schizophrenia; LUSC cis rs13082711 0.911 rs6797389 chr3:27502070 G/T cg02860705 chr3:27208620 NA 0.5 8.35 0.42 1.86e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs601339 1.000 rs1798219 chr12:123180061 A/C cg11919336 chr12:123188078 GPR109A 0.43 6.52 0.34 2.64e-10 Adiponectin levels; LUSC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg08704250 chr15:31115839 NA -0.57 -8.78 -0.43 8.33e-17 Huntington's disease progression; LUSC cis rs9902453 0.904 rs4598962 chr17:28293948 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.13 0.48 3.31e-21 Coffee consumption (cups per day); LUSC cis rs6665290 0.669 rs3795445 chr1:227180947 A/C cg10327440 chr1:227177885 CDC42BPA -1.11 -29.49 -0.85 5.51e-95 Myeloid white cell count; LUSC cis rs10203711 0.966 rs6713626 chr2:239566896 C/T cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg01689657 chr7:91764605 CYP51A1 0.34 6.13 0.32 2.52e-9 Breast cancer; LUSC cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -7.03 -0.36 1.15e-11 Chronic sinus infection; LUSC cis rs4073582 0.595 rs3016319 chr11:65981846 C/T cg16950941 chr11:66035639 RAB1B 0.51 7.4 0.38 1.09e-12 Gout; LUSC cis rs9653442 0.547 rs1062143 chr2:100659796 A/G cg07810366 chr2:100720526 AFF3 -0.43 -7.16 -0.36 5.29e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg23158103 chr7:148848205 ZNF398 -0.45 -7.29 -0.37 2.28e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs2652834 0.851 rs1566660 chr15:63429258 C/G cg05507819 chr15:63340323 TPM1 0.44 5.74 0.3 2.16e-8 HDL cholesterol; LUSC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg16743903 chr16:89593216 SPG7 -0.41 -5.72 -0.3 2.32e-8 Multiple myeloma (IgH translocation); LUSC cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs78456975 1.000 rs72778004 chr2:1571892 T/A cg01028140 chr2:1542097 TPO -0.6 -8.14 -0.41 7.81e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9325144 0.560 rs13377717 chr12:38639474 T/A cg26384229 chr12:38710491 ALG10B -0.67 -10.45 -0.5 2.63e-22 Morning vs. evening chronotype; LUSC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.908 rs7696649 chr4:120322177 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC trans rs7939886 0.920 rs1586014 chr11:55771540 C/T cg03929089 chr4:120376271 NA 0.79 6.79 0.35 5.1e-11 Myopia (pathological); LUSC cis rs8044995 0.501 rs73613952 chr16:68352808 G/C cg05110241 chr16:68378359 PRMT7 -0.82 -8.37 -0.42 1.55e-15 Schizophrenia; LUSC cis rs116975820 0.697 rs11181433 chr12:42733559 A/G cg01256987 chr12:42539512 GXYLT1 -0.46 -6.01 -0.31 4.88e-9 PR interval in Tripanosoma cruzi seropositivity; LUSC cis rs7727544 0.716 rs6863213 chr5:131575932 C/T cg14196790 chr5:131705035 SLC22A5 0.5 8.52 0.42 5.4e-16 Blood metabolite levels; LUSC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.67 -10.16 -0.49 2.61e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg06145435 chr7:1022769 CYP2W1 0.34 7.37 0.37 1.38e-12 Longevity;Endometriosis; LUSC cis rs2235649 0.833 rs9939766 chr16:1852808 C/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.13 -0.32 2.55e-9 Blood metabolite levels; LUSC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg09455208 chr3:40491958 NA 0.59 10.09 0.48 4.36e-21 Renal cell carcinoma; LUSC cis rs7647973 0.559 rs9586 chr3:49213637 C/T cg06212747 chr3:49208901 KLHDC8B 0.48 5.88 0.31 9.74e-9 Menarche (age at onset); LUSC cis rs727505 0.607 rs59635547 chr7:124796371 A/C cg23710748 chr7:124431027 NA -0.39 -6.77 -0.35 5.67e-11 Lewy body disease; LUSC cis rs8099014 1.000 rs9319929 chr18:56115825 A/C cg12907477 chr18:56117327 MIR122 0.43 6.81 0.35 4.5e-11 Platelet count; LUSC cis rs10911232 0.507 rs10797820 chr1:183011366 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.67e-24 Hypertriglyceridemia; LUSC cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg04586622 chr2:25135609 ADCY3 0.32 6.18 0.32 1.92e-9 Body mass index; LUSC cis rs12545109 0.800 rs2118260 chr8:57393481 T/C cg09654669 chr8:57350985 NA -0.51 -6.78 -0.35 5.55e-11 Obesity-related traits; LUSC cis rs10892173 0.545 rs115865940 chr11:117666711 C/T cg07621104 chr11:117668040 DSCAML1 0.51 6.82 0.35 4.18e-11 Myopia; LUSC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg08859206 chr1:53392774 SCP2 0.46 7.64 0.39 2.33e-13 Monocyte count; LUSC cis rs7824557 0.767 rs3808513 chr8:11157460 G/T cg21775007 chr8:11205619 TDH -0.68 -10.91 -0.51 6.54e-24 Retinal vascular caliber; LUSC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg15145296 chr3:125709740 NA -0.59 -6.67 -0.34 1.06e-10 Blood pressure (smoking interaction); LUSC cis rs2109514 0.902 rs1007751 chr7:116110055 A/T cg12739419 chr7:116140593 CAV2 -0.27 -5.94 -0.31 7.3e-9 Prevalent atrial fibrillation; LUSC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg18825119 chr6:163149453 PACRG;PARK2 -0.35 -6.23 -0.32 1.43e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7267979 1.000 rs6050590 chr20:25384994 G/A cg03522245 chr20:25566470 NINL -0.35 -5.68 -0.3 2.93e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9311676 0.618 rs11130639 chr3:58406004 G/T cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.3e-10 Systemic lupus erythematosus; LUSC cis rs72781680 0.752 rs72796119 chr2:23917179 C/T cg08917208 chr2:24149416 ATAD2B 0.99 10.11 0.48 4.01e-21 Lymphocyte counts; LUSC cis rs4964805 0.913 rs36034617 chr12:104203615 G/C cg02344784 chr12:104178138 NT5DC3 0.43 6.93 0.35 2.2e-11 Attention deficit hyperactivity disorder; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.69 0.54 1.04e-26 Prudent dietary pattern; LUSC cis rs11122272 0.735 rs2491405 chr1:231513431 C/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs72634258 0.554 rs35123409 chr1:7878568 C/T cg26816564 chr1:7831052 VAMP3 0.96 12.48 0.56 1.37e-29 Inflammatory bowel disease; LUSC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg24829409 chr8:58192753 C8orf71 -0.64 -6.63 -0.34 1.32e-10 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg22467129 chr15:76604101 ETFA -0.51 -8.25 -0.41 3.8e-15 Blood metabolite levels; LUSC cis rs709400 0.628 rs12879085 chr14:103874420 G/A cg10523860 chr14:103875565 MARK3 0.4 6.48 0.33 3.3e-10 Body mass index; LUSC cis rs9788721 1.000 rs9788721 chr15:78802869 C/T cg06917634 chr15:78832804 PSMA4 0.43 6.13 0.32 2.54e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs1524927 0.933 rs11769570 chr7:96359716 C/G cg03808172 chr7:96339361 SHFM1 0.43 6.53 0.34 2.48e-10 Total body bone mineral density; LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs8056893 0.569 rs9935025 chr16:68307447 C/T cg02226672 chr16:68398533 SMPD3 -0.29 -5.67 -0.3 3.02e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC trans rs1459104 0.866 rs34179570 chr11:54823141 C/T cg03929089 chr4:120376271 NA 0.7 6.08 0.32 3.27e-9 Body mass index; LUSC cis rs1595825 0.891 rs4491721 chr2:198521407 C/G cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.34e-10 Ulcerative colitis; LUSC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg01475377 chr6:109611718 NA -0.42 -7.4 -0.38 1.13e-12 Reticulocyte fraction of red cells; LUSC cis rs2072499 0.932 rs2540183 chr1:156164885 C/G cg25208724 chr1:156163844 SLC25A44 1.11 24.06 0.8 6.29e-75 Testicular germ cell tumor; LUSC cis rs4919694 1.000 rs78893207 chr10:104796138 T/C cg23093090 chr10:104574429 C10orf26 -0.47 -5.76 -0.3 1.94e-8 Arsenic metabolism; LUSC cis rs9807989 0.507 rs1035129 chr2:103019785 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC cis rs826838 0.586 rs10880753 chr12:38628147 C/A cg26384229 chr12:38710491 ALG10B -0.56 -8.46 -0.42 8.73e-16 Heart rate; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16523621 chr5:172721053 NA 0.73 6.56 0.34 2.11e-10 Cognitive performance; LUSC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg09640425 chr7:158790006 NA -0.41 -6.47 -0.33 3.53e-10 Facial morphology (factor 20); LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg20887711 chr4:1340912 KIAA1530 -0.41 -6.48 -0.33 3.19e-10 Obesity-related traits; LUSC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg13390004 chr1:15929781 NA 0.42 7.04 0.36 1.07e-11 Systolic blood pressure; LUSC cis rs1322512 0.917 rs2800651 chr6:152976421 C/A cg27316956 chr6:152958899 SYNE1 -0.37 -6.3 -0.33 9.2e-10 Tonometry; LUSC cis rs2486288 0.656 rs11854365 chr15:45558083 G/A cg09092052 chr15:45571596 NA 0.45 6.3 0.33 9.44e-10 Glomerular filtration rate; LUSC cis rs34779708 0.931 rs11597483 chr10:35285117 A/G cg04310649 chr10:35416472 CREM -0.44 -6.56 -0.34 2.03e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.23 0.37 3.3e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6961069 0.749 rs4316098 chr7:80259988 C/T cg04458919 chr7:80252533 CD36 0.37 6.68 0.34 1.02e-10 Platelet count; LUSC trans rs61931739 0.500 rs11053066 chr12:34185318 G/A cg26384229 chr12:38710491 ALG10B 0.74 11.9 0.55 1.78e-27 Morning vs. evening chronotype; LUSC trans rs7772697 0.508 rs13217006 chr6:149375716 C/G cg22609380 chr12:98849379 NA 0.34 6.02 0.31 4.54e-9 Diabetic retinopathy; LUSC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg09323728 chr8:95962352 TP53INP1 -0.38 -7.74 -0.39 1.2e-13 Type 2 diabetes; LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.53 -9.39 -0.46 9.4e-19 Bipolar disorder; LUSC cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg19875535 chr5:140030758 IK 0.54 8.95 0.44 2.48e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs9815354 0.812 rs57209010 chr3:41854743 A/T cg03022575 chr3:42003672 ULK4 0.83 8.75 0.43 1.07e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6750795 0.602 rs1667317 chr2:232412036 T/C cg19187155 chr2:232395269 NMUR1 0.77 11.05 0.52 2.08e-24 Height; LUSC cis rs11637445 0.603 rs1478941 chr15:68127141 A/G cg08079166 chr15:68083412 MAP2K5 0.35 7.05 0.36 1.04e-11 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg22681709 chr2:178499509 PDE11A -0.49 -8.98 -0.44 2.06e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg03806693 chr22:41940476 POLR3H 0.99 14.14 0.61 6.88e-36 Vitiligo; LUSC cis rs5758659 1.000 rs134882 chr22:42670965 A/G cg15557168 chr22:42548783 NA -0.41 -7.01 -0.36 1.33e-11 Cognitive function; LUSC cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.26 34.21 0.88 3.37e-111 Chronic sinus infection; LUSC cis rs1577917 0.958 rs36053156 chr6:86575509 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.98 -0.36 1.58e-11 Response to antipsychotic treatment; LUSC cis rs9616064 0.531 rs867212 chr22:47063330 C/T cg05621596 chr22:47072043 GRAMD4 0.53 8.68 0.43 1.75e-16 Urate levels in obese individuals; LUSC cis rs3733606 0.538 rs11734099 chr4:6891435 G/A cg05012661 chr4:6891264 NA 0.59 8.35 0.42 1.82e-15 Platelet count; LUSC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg03806693 chr22:41940476 POLR3H -0.86 -12.34 -0.56 4.3e-29 Vitiligo; LUSC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.64 9.76 0.47 5.84e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9650315 0.706 rs36112366 chr8:57138676 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.7 0.39 1.53e-13 Height; LUSC cis rs6701037 1.000 rs6425323 chr1:175125036 C/T cg17845761 chr1:175162550 KIAA0040 -0.31 -6.0 -0.31 5.07e-9 Alcohol dependence; LUSC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg14784868 chr12:69753453 YEATS4 0.65 9.67 0.47 1.12e-19 Blood protein levels; LUSC cis rs28448403 1 rs28448403 chr8:11305564 G/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.33 -5.74 -0.3 2.1e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs80282103 0.618 rs1079389 chr10:1161980 A/G cg18964960 chr10:1102726 WDR37 0.7 5.84 0.3 1.22e-8 Glomerular filtration rate (creatinine); LUSC cis rs11608355 0.552 rs2304549 chr12:109794875 A/G cg19025524 chr12:109796872 NA -0.48 -9.16 -0.45 5.49e-18 Neuroticism; LUSC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.91 -0.4 3.78e-14 Blood metabolite levels; LUSC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg19622623 chr12:86230825 RASSF9 -0.46 -6.62 -0.34 1.48e-10 Major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23307708 chr5:133561976 PPP2CA -0.49 -6.2 -0.32 1.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs7119 0.651 rs12917044 chr15:77850146 A/G cg27398640 chr15:77910606 LINGO1 0.32 6.86 0.35 3.3e-11 Type 2 diabetes; LUSC cis rs7647973 1.000 rs9842132 chr3:49427933 G/A cg07636037 chr3:49044803 WDR6 -0.69 -9.2 -0.45 4.05e-18 Menarche (age at onset); LUSC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg18225595 chr11:63971243 STIP1 0.58 9.44 0.46 6.74e-19 Platelet count; LUSC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg17366294 chr4:99064904 C4orf37 0.54 9.6 0.47 1.91e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2625529 0.761 rs11853268 chr15:72238973 T/C cg16672083 chr15:72433130 SENP8 -0.51 -7.49 -0.38 6.37e-13 Red blood cell count; LUSC cis rs76878669 0.561 rs10791876 chr11:66169646 C/T cg18002602 chr11:66138449 SLC29A2 -0.49 -8.8 -0.43 7.57e-17 Educational attainment (years of education); LUSC cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.13 0.55 2.61e-28 Motion sickness; LUSC cis rs11122272 0.766 rs2486732 chr1:231531476 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.4 -0.49 3.84e-22 Hemoglobin concentration; LUSC cis rs1865760 0.865 rs9393678 chr6:25945819 C/T cg12310025 chr6:25882481 NA -0.34 -5.72 -0.3 2.41e-8 Height; LUSC cis rs1568889 1.000 rs11826837 chr11:28322566 C/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.65 -9.41 -0.46 8.6e-19 Bipolar disorder; LUSC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg02269571 chr22:50332266 NA -0.51 -7.53 -0.38 4.88e-13 Schizophrenia; LUSC cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg03517284 chr6:25882590 NA -0.32 -5.71 -0.3 2.49e-8 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23000811 chr4:2464397 NA -0.38 -6.18 -0.32 1.91e-9 Electrocardiographic conduction measures; LUSC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg20848291 chr7:100343083 ZAN -0.67 -9.26 -0.45 2.5e-18 Other erythrocyte phenotypes; LUSC cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg13010199 chr12:38710504 ALG10B 0.66 9.97 0.48 1.11e-20 Bladder cancer; LUSC trans rs895636 1.000 rs895636 chr2:45188353 A/G cg26822602 chr1:247418074 VN1R5 0.41 6.12 0.32 2.61e-9 Metabolite levels;Fasting plasma glucose; LUSC cis rs8062405 1.000 rs12325113 chr16:28848668 T/C cg05966235 chr16:28915196 ATP2A1 0.34 5.96 0.31 6.43e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg18252515 chr7:66147081 NA -1.23 -13.41 -0.59 4.23e-33 Diabetic kidney disease; LUSC cis rs1670533 0.872 rs6854793 chr4:1055768 T/C cg02018176 chr4:1364513 KIAA1530 0.44 6.05 0.31 3.91e-9 Recombination rate (females); LUSC cis rs1018836 0.663 rs4735190 chr8:91509601 A/G cg16814680 chr8:91681699 NA -0.71 -10.89 -0.51 7.52e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg23985595 chr17:80112537 CCDC57 -0.3 -5.91 -0.31 8.55e-9 Life satisfaction; LUSC cis rs4409675 0.576 rs10794507 chr1:28216072 T/C cg23691781 chr1:28212827 C1orf38 0.31 7.43 0.38 8.99e-13 Corneal astigmatism; LUSC cis rs28655083 0.529 rs1847161 chr16:77097796 C/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 6.99 0.36 1.5e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg23788917 chr6:8435910 SLC35B3 0.51 7.56 0.38 3.86e-13 Motion sickness; LUSC cis rs17407555 0.697 rs73212821 chr4:10069451 T/A cg11266682 chr4:10021025 SLC2A9 -0.48 -6.48 -0.33 3.27e-10 Schizophrenia (age at onset); LUSC cis rs2762353 0.935 rs1177442 chr6:25809069 A/G cg03264133 chr6:25882463 NA -0.42 -7.28 -0.37 2.42e-12 Blood metabolite levels; LUSC cis rs7107174 1.000 rs2510047 chr11:77988668 C/T cg02023728 chr11:77925099 USP35 -0.44 -6.56 -0.34 2.1e-10 Testicular germ cell tumor; LUSC trans rs3808502 0.549 rs11991139 chr8:11428395 C/T cg08975724 chr8:8085496 FLJ10661 -0.53 -7.57 -0.38 3.63e-13 Neuroticism; LUSC cis rs6545883 0.868 rs7574631 chr2:61825142 T/G cg15711740 chr2:61764176 XPO1 -0.46 -7.31 -0.37 1.97e-12 Tuberculosis; LUSC cis rs3749237 0.964 rs34522271 chr3:49808517 A/G cg03060546 chr3:49711283 APEH 0.59 8.22 0.41 4.42e-15 Resting heart rate; LUSC trans rs9650657 0.538 rs6984496 chr8:10796093 G/T cg15556689 chr8:8085844 FLJ10661 -0.52 -7.75 -0.39 1.1e-13 Neuroticism; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22029157 chr1:209979665 IRF6 0.84 17.31 0.69 2.38e-48 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs9467773 0.596 rs2451750 chr6:26646579 A/T cg11502198 chr6:26597334 ABT1 0.72 12.19 0.56 1.53e-28 Intelligence (multi-trait analysis); LUSC cis rs9549367 0.826 rs35306827 chr13:113869045 G/A cg00898013 chr13:113819073 PROZ -0.6 -8.48 -0.42 7.38e-16 Platelet distribution width; LUSC trans rs853679 0.882 rs2743555 chr6:28241081 G/A cg06606381 chr12:133084897 FBRSL1 -0.56 -6.55 -0.34 2.16e-10 Depression; LUSC cis rs7580658 0.929 rs13029237 chr2:128147854 C/T cg09760422 chr2:128146352 NA -0.33 -7.3 -0.37 2.12e-12 Protein C levels; LUSC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs9814567 0.896 rs13089566 chr3:134349710 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.86 14.36 0.62 9.18e-37 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg19318889 chr4:1322082 MAEA -0.54 -8.76 -0.43 1.02e-16 Obesity-related traits; LUSC cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg04850211 chr1:228464232 OBSCN 0.32 5.77 0.3 1.78e-8 Diastolic blood pressure; LUSC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg22823121 chr1:150693482 HORMAD1 0.5 7.44 0.38 8.47e-13 Melanoma; LUSC cis rs9815354 0.812 rs73073358 chr3:41842527 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs79149102 0.579 rs58645417 chr15:75325858 T/G cg09165964 chr15:75287851 SCAMP5 -0.93 -8.66 -0.43 2.11e-16 Lung cancer; LUSC cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg08807101 chr21:30365312 RNF160 0.79 14.68 0.63 5.37e-38 Dental caries; LUSC cis rs4077515 0.870 rs11793497 chr9:139271850 A/G cg14169450 chr9:139327907 INPP5E 0.42 7.53 0.38 4.81e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC trans rs9409565 0.826 rs4612412 chr9:97208627 C/G cg05679027 chr9:99775184 HIATL2 -0.5 -7.2 -0.37 4e-12 Colorectal cancer (alcohol consumption interaction); LUSC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.15 -0.36 5.49e-12 Major depressive disorder; LUSC cis rs73206853 0.620 rs55845219 chr12:111164875 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.69 0.34 9.64e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1595825 0.891 rs76308665 chr2:198518062 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -5.75 -0.3 2.02e-8 Ulcerative colitis; LUSC cis rs7582180 0.627 rs6749018 chr2:101001859 G/T cg08017756 chr2:100939284 LONRF2 -0.39 -7.21 -0.37 3.8e-12 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.797 rs6843530 chr4:17593605 G/T cg18681998 chr4:17616180 MED28 0.84 15.2 0.64 4.81e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6543140 0.964 rs10200081 chr2:103091556 T/C cg09003973 chr2:102972529 NA 0.54 6.83 0.35 4.07e-11 Blood protein levels; LUSC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg06634786 chr22:41940651 POLR3H -0.55 -6.33 -0.33 7.74e-10 Vitiligo; LUSC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.75 0.43 1.09e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg08888203 chr3:10149979 C3orf24 0.59 8.2 0.41 5.23e-15 Alzheimer's disease; LUSC cis rs208520 0.690 rs864314 chr6:66814830 G/A cg07460842 chr6:66804631 NA -1.25 -27.39 -0.83 2.17e-87 Exhaled nitric oxide output; LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs1878931 0.582 rs10048083 chr16:3417465 A/C cg22508957 chr16:3507546 NAT15 -0.4 -5.7 -0.3 2.66e-8 Body mass index (adult); LUSC cis rs1790761 0.692 rs10444362 chr11:67333090 G/A cg00290607 chr11:67383545 NA 0.35 6.58 0.34 1.81e-10 Mean corpuscular volume; LUSC trans rs1941687 0.505 rs9956918 chr18:31315878 C/G cg27147174 chr7:100797783 AP1S1 0.51 7.71 0.39 1.47e-13 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg12463550 chr7:65579703 CRCP -0.56 -8.21 -0.41 4.95e-15 Aortic root size; LUSC cis rs9039 1.000 rs17567434 chr16:9221447 C/G cg08831531 chr16:9218945 NA -0.65 -9.82 -0.47 3.59e-20 Menopause (age at onset); LUSC cis rs642803 0.551 rs1308020 chr11:65497558 G/A cg27068330 chr11:65405492 SIPA1 0.55 7.54 0.38 4.38e-13 Urate levels; LUSC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.59 -5.76 -0.3 1.91e-8 Cerebrospinal P-tau181p levels; LUSC cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.46 -5.79 -0.3 1.63e-8 Renal function-related traits (BUN); LUSC cis rs7829975 0.742 rs7832968 chr8:8652889 G/A cg17143192 chr8:8559678 CLDN23 0.39 5.93 0.31 7.46e-9 Mood instability; LUSC cis rs6882046 0.513 rs676096 chr5:88035887 C/T cg22951263 chr5:87985283 NA -0.45 -7.25 -0.37 2.85e-12 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC cis rs593982 1.000 rs665191 chr11:65493658 G/A cg08755490 chr11:65554678 OVOL1 1.43 15.16 0.64 7.19e-40 Atopic dermatitis; LUSC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg03388025 chr16:89894329 SPIRE2 0.33 7.01 0.36 1.35e-11 Vitiligo; LUSC cis rs6690583 0.623 rs12042160 chr1:85504516 A/G cg11262906 chr1:85462892 MCOLN2 0.64 6.03 0.31 4.23e-9 Serum sulfate level; LUSC cis rs7094131 0.523 rs10741008 chr10:22882344 T/G cg19500236 chr10:22911537 PIP4K2A 0.36 6.23 0.32 1.38e-9 Obesity-related traits; LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.88 -11.63 -0.54 1.72e-26 Platelet count; LUSC cis rs478304 0.651 rs11227279 chr11:65495211 G/A cg10518572 chr11:65560635 OVOL1 -0.26 -6.0 -0.31 5.05e-9 Acne (severe); LUSC cis rs2580764 0.565 rs2919129 chr2:55216545 G/T cg20993754 chr2:55226987 RTN4 -0.33 -5.65 -0.3 3.39e-8 Mean platelet volume; LUSC cis rs9814567 0.752 rs4634170 chr3:134335471 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.48 -0.56 1.33e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg21984481 chr17:79567631 NPLOC4 0.58 11.22 0.52 5.07e-25 Eye color traits; LUSC trans rs1493916 0.721 rs4471760 chr18:31374233 G/A cg15819921 chr19:927150 ARID3A -0.43 -6.44 -0.33 4.06e-10 Life satisfaction; LUSC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg27432699 chr2:27873401 GPN1 -0.59 -8.9 -0.44 3.72e-17 Menopause (age at onset); LUSC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg23791538 chr6:167370224 RNASET2 -0.41 -6.51 -0.34 2.74e-10 Crohn's disease; LUSC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.48 0.46 4.86e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs936229 0.690 rs2445618 chr15:75035256 T/C cg10253484 chr15:75165896 SCAMP2 -0.49 -6.63 -0.34 1.33e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg12257692 chr3:49977190 RBM6 0.25 6.82 0.35 4.23e-11 Body mass index; LUSC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg00376283 chr12:123451042 ABCB9 0.68 8.54 0.42 4.8e-16 Neutrophil percentage of white cells; LUSC cis rs12369635 1.000 rs11060121 chr12:129564206 C/T cg01909103 chr12:129572610 TMEM132D -0.6 -5.72 -0.3 2.41e-8 Schizophrenia (inflammation and infection response interaction); LUSC trans rs853679 0.607 rs34166054 chr6:28065801 T/C cg06606381 chr12:133084897 FBRSL1 -1.05 -9.22 -0.45 3.34e-18 Depression; LUSC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.58 -8.85 -0.44 5.14e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2404602 0.660 rs11852777 chr15:76929792 A/G cg23625390 chr15:77176239 SCAPER -0.66 -10.26 -0.49 1.16e-21 Blood metabolite levels; LUSC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.81 0.35 4.42e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs1461503 0.534 rs7944405 chr11:122816099 A/G cg27398637 chr11:122830231 C11orf63 -0.41 -6.75 -0.35 6.47e-11 Menarche (age at onset); LUSC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg20891283 chr12:69753455 YEATS4 0.63 9.58 0.46 2.27e-19 Blood protein levels; LUSC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg13256891 chr4:100009986 ADH5 -0.43 -6.0 -0.31 5.06e-9 Alcohol dependence; LUSC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg22823121 chr1:150693482 HORMAD1 0.49 7.03 0.36 1.17e-11 Melanoma; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg25072359 chr17:41440525 NA 0.64 9.04 0.44 1.26e-17 Menopause (age at onset); LUSC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs7474896 0.537 rs2749586 chr10:38270214 G/C cg25427524 chr10:38739819 LOC399744 0.43 5.74 0.3 2.09e-8 Obesity (extreme); LUSC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg23188684 chr11:67383651 NA 0.34 6.01 0.31 4.86e-9 Mean corpuscular volume; LUSC trans rs9329221 0.905 rs6601451 chr8:10243681 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.05 -0.4 1.43e-14 Neuroticism; LUSC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg11871910 chr12:69753446 YEATS4 0.9 16.75 0.68 3.71e-46 Cerebrospinal fluid biomarker levels; LUSC cis rs9611565 0.879 rs2235845 chr22:41729294 T/G cg03806693 chr22:41940476 POLR3H -0.74 -11.1 -0.52 1.37e-24 Vitiligo; LUSC cis rs9987353 0.522 rs2929466 chr8:9063899 G/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.5 -0.34 2.93e-10 Recombination measurement; LUSC cis rs3820928 0.874 rs2276593 chr2:227898434 A/G cg11843606 chr2:227700838 RHBDD1 0.55 7.83 0.39 6.55e-14 Pulmonary function; LUSC cis rs6076065 0.723 rs2424550 chr20:23394669 C/T cg11657817 chr20:23433608 CST11 0.44 8.19 0.41 5.54e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs951366 0.576 rs7513645 chr1:205698026 A/G cg14893161 chr1:205819251 PM20D1 0.48 6.49 0.33 3.02e-10 Menarche (age at onset); LUSC cis rs1775715 0.678 rs2778649 chr10:32146803 C/G cg18675610 chr10:32216311 ARHGAP12 0.32 6.91 0.35 2.39e-11 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7243066 0.577 rs9957564 chr18:11296178 A/G cg26633107 chr2:14774086 FAM84A -0.48 -6.57 -0.34 1.91e-10 Dental caries; LUSC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg06453172 chr10:134556979 INPP5A -0.49 -6.02 -0.31 4.48e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs8179 0.593 rs17164683 chr7:92286980 C/T cg15732164 chr7:92237376 CDK6 -0.42 -6.15 -0.32 2.22e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs2130392 0.892 rs11728389 chr4:185622046 C/T cg04058563 chr4:185651563 MLF1IP -0.41 -6.6 -0.34 1.63e-10 Kawasaki disease; LUSC cis rs8017423 0.967 rs11621364 chr14:90709115 A/G cg14092571 chr14:90743983 NA -0.35 -5.67 -0.3 3.12e-8 Mortality in heart failure; LUSC trans rs61931739 0.517 rs10844738 chr12:34059503 T/A cg26384229 chr12:38710491 ALG10B 0.69 10.88 0.51 8.48e-24 Morning vs. evening chronotype; LUSC cis rs8114671 0.935 rs6058198 chr20:33748253 T/A cg07148914 chr20:33460835 GGT7 0.47 6.99 0.36 1.55e-11 Height; LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.18 -0.37 4.54e-12 Menopause (age at onset); LUSC cis rs1018836 0.608 rs7821069 chr8:91465548 C/G cg16814680 chr8:91681699 NA -0.48 -7.11 -0.36 6.97e-12 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7100689 0.753 rs4934125 chr10:82147466 T/C cg00277334 chr10:82204260 NA -0.48 -6.35 -0.33 6.97e-10 Post bronchodilator FEV1; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16649755 chr6:88412160 NCRNA00120;AKIRIN2 0.36 6.17 0.32 2e-9 Triglycerides; LUSC cis rs1864400 0.605 rs12360493 chr10:43718613 A/G cg02780029 chr10:43622663 RET 0.35 6.03 0.31 4.37e-9 Hirschsprung disease; LUSC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg17366294 chr4:99064904 C4orf37 0.59 10.56 0.5 1.12e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs870825 0.616 rs745656 chr4:185637523 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC trans rs10432489 0.708 rs4416179 chr2:181751896 T/C cg04744134 chr19:8408128 KANK3 -0.81 -6.36 -0.33 6.68e-10 QT interval; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg10150615 chr22:24372951 LOC391322 -0.43 -7.23 -0.37 3.22e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg16624210 chr5:671434 TPPP 0.48 5.84 0.3 1.24e-8 Lung disease severity in cystic fibrosis; LUSC cis rs77633900 0.614 rs2585730 chr15:76989344 A/G cg21673338 chr15:77095150 SCAPER -0.77 -8.04 -0.4 1.56e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs11971779 0.688 rs8137 chr7:139104461 A/C cg07862535 chr7:139043722 LUC7L2 -0.54 -6.87 -0.35 3.18e-11 Diisocyanate-induced asthma; LUSC cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg15839431 chr19:19639596 YJEFN3 -0.59 -6.45 -0.33 3.91e-10 Bipolar disorder; LUSC cis rs9443645 0.507 rs9352633 chr6:79462623 C/G cg05283184 chr6:79620031 NA -0.37 -7.0 -0.36 1.39e-11 Intelligence (multi-trait analysis); LUSC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg20607287 chr7:12443886 VWDE -0.65 -6.45 -0.33 4.01e-10 Coronary artery disease; LUSC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg11871910 chr12:69753446 YEATS4 0.83 14.65 0.63 7.16e-38 Blood protein levels; LUSC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg11764359 chr7:65958608 NA 0.68 10.89 0.51 7.59e-24 Aortic root size; LUSC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg05585544 chr11:47624801 NA -0.42 -7.26 -0.37 2.71e-12 Subjective well-being; LUSC trans rs1486139 0.967 rs1903671 chr7:46282312 G/A cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs3806843 1.000 rs2240694 chr5:140183058 G/A cg19875535 chr5:140030758 IK 0.49 8.14 0.41 7.85e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg07936489 chr17:37558343 FBXL20 0.71 9.91 0.48 1.88e-20 Glomerular filtration rate (creatinine); LUSC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.25 0.41 3.72e-15 Height; LUSC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg18681998 chr4:17616180 MED28 0.76 13.57 0.6 1.07e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs478304 0.654 rs12289836 chr11:65436888 C/T cg27068330 chr11:65405492 SIPA1 0.77 10.63 0.5 6.34e-23 Acne (severe); LUSC cis rs7937682 0.883 rs11213941 chr11:111434094 T/C cg09085632 chr11:111637200 PPP2R1B 0.99 14.52 0.62 2.26e-37 Primary sclerosing cholangitis; LUSC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg23985595 chr17:80112537 CCDC57 -0.33 -6.51 -0.34 2.77e-10 Life satisfaction; LUSC cis rs4601821 0.895 rs1055075 chr11:113239512 T/C cg14159747 chr11:113255604 NA 0.26 5.96 0.31 6.36e-9 Alcoholic chronic pancreatitis; LUSC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg22907277 chr7:1156413 C7orf50 0.73 11.0 0.52 3.14e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13315871 1.000 rs71311873 chr3:58447106 C/A cg20936604 chr3:58311152 NA -0.72 -6.77 -0.35 5.83e-11 Cholesterol, total; LUSC cis rs4925114 0.568 rs11656775 chr17:17654319 A/G cg09796270 chr17:17721594 SREBF1 -0.43 -7.27 -0.37 2.6e-12 Body mass index; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.65 9.98 0.48 1.02e-20 Lymphocyte counts; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg11645453 chr3:52864694 ITIH4 0.35 8.1 0.41 1.07e-14 Bipolar disorder; LUSC cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg12573674 chr2:1569213 NA -0.56 -7.51 -0.38 5.52e-13 IgG glycosylation; LUSC cis rs8018808 0.935 rs11159263 chr14:77930188 G/C cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs62400317 0.859 rs10948204 chr6:45124300 T/C cg20913747 chr6:44695427 NA -0.46 -7.49 -0.38 6.35e-13 Total body bone mineral density; LUSC cis rs56399783 0.901 rs73049341 chr7:2812255 G/C cg14895029 chr7:2775587 GNA12 0.47 5.82 0.3 1.41e-8 Childhood ear infection; LUSC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg24531977 chr5:56204891 C5orf35 -0.57 -8.51 -0.42 6.03e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs983392 0.836 rs12453 chr11:59945745 T/C cg02771260 chr11:59836817 MS4A3 -0.37 -5.96 -0.31 6.38e-9 Alzheimer's disease (late onset); LUSC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.33 -0.33 8.02e-10 Bipolar disorder and schizophrenia; LUSC cis rs981844 0.816 rs74549610 chr4:154710464 C/G cg14289246 chr4:154710475 SFRP2 0.49 6.0 0.31 5.18e-9 Response to statins (LDL cholesterol change); LUSC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg25019033 chr10:957182 NA -0.5 -6.19 -0.32 1.81e-9 Eosinophil percentage of granulocytes; LUSC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg15145296 chr3:125709740 NA -0.56 -6.31 -0.33 8.95e-10 Blood pressure (smoking interaction); LUSC cis rs11605924 1.000 rs12794698 chr11:45871861 G/A ch.11.939596F chr11:45881766 CRY2 -0.52 -7.87 -0.4 4.93e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg22963979 chr7:1858916 MAD1L1 -0.55 -8.35 -0.42 1.78e-15 Bipolar disorder and schizophrenia; LUSC cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.84 0.51 1.15e-23 Heart rate; LUSC cis rs1443512 0.812 rs1975470 chr12:54336841 G/A cg17410650 chr12:54324560 NA -0.58 -10.14 -0.49 2.97e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg24549020 chr5:56110836 MAP3K1 0.43 5.74 0.3 2.18e-8 Initial pursuit acceleration; LUSC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 14.49 0.62 2.83e-37 Allergic disease (asthma, hay fever or eczema); LUSC trans rs11039798 0.588 rs61932767 chr11:48704806 C/T cg03929089 chr4:120376271 NA 0.64 7.35 0.37 1.58e-12 Axial length; LUSC cis rs10740039 0.883 rs10994446 chr10:62399191 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1419980 0.722 rs752452 chr12:7781021 G/A cg10578777 chr12:7781093 NA 0.59 6.47 0.33 3.44e-10 HDL cholesterol levels; LUSC trans rs1728785 1.000 rs1728792 chr16:68596534 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.25 0.41 3.64e-15 Ulcerative colitis; LUSC cis rs55665837 1.000 rs11023223 chr11:14457112 A/G cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 7.25e-13 Vitamin D levels; LUSC cis rs644799 0.710 rs11021309 chr11:95501898 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.13 0.58 4.89e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25536300 chr19:797459 PTBP1 -0.52 -6.13 -0.32 2.49e-9 Bipolar disorder and schizophrenia; LUSC trans rs2562456 0.833 rs56187954 chr19:21528060 T/A cg00806126 chr19:22604979 ZNF98 -0.43 -6.12 -0.32 2.66e-9 Pain; LUSC cis rs9388451 0.872 rs2008027 chr6:126052359 A/G cg10911889 chr6:126070802 HEY2 0.41 6.23 0.32 1.38e-9 Brugada syndrome; LUSC cis rs7264396 0.623 rs78949029 chr20:34384964 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -7.91 -0.4 3.93e-14 Total cholesterol levels; LUSC trans rs3733585 0.638 rs6449155 chr4:9956547 T/G cg26043149 chr18:55253948 FECH -0.45 -7.02 -0.36 1.23e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs459571 0.834 rs379417 chr9:136890704 G/A cg13789015 chr9:136890014 NCRNA00094 0.7 12.69 0.57 2.29e-30 Platelet distribution width; LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg01802117 chr1:53393560 SCP2 -0.37 -6.12 -0.32 2.55e-9 Monocyte count; LUSC trans rs7556897 0.720 rs10177876 chr2:228664003 A/G cg07776931 chr3:126135051 CCDC37 -0.28 -5.96 -0.31 6.42e-9 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10911232 0.526 rs41475048 chr1:183058452 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.54 -7.15 -0.36 5.62e-12 Hypertriglyceridemia; LUSC trans rs9329221 0.935 rs3750311 chr8:10283602 C/A cg08975724 chr8:8085496 FLJ10661 -0.46 -6.55 -0.34 2.18e-10 Neuroticism; LUSC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.95 -0.4 2.98e-14 Chronic sinus infection; LUSC cis rs2227564 0.620 rs11000785 chr10:75575963 T/C cg23231163 chr10:75533350 FUT11 -0.45 -6.5 -0.34 2.94e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4363385 0.626 rs11205179 chr1:153021399 A/G cg00922841 chr1:152955080 SPRR1A -0.38 -6.4 -0.33 5.37e-10 Inflammatory skin disease; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg21548813 chr6:291882 DUSP22 -0.5 -7.57 -0.38 3.77e-13 Menopause (age at onset); LUSC cis rs6867032 0.917 rs10474734 chr5:2004208 A/G cg26168224 chr5:2018326 NA 0.69 12.03 0.55 6e-28 Gut microbiome composition (winter); LUSC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg22467129 chr15:76604101 ETFA -0.44 -6.88 -0.35 3.01e-11 Blood metabolite levels; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg23712970 chr14:23540735 ACIN1 0.53 6.34 0.33 7.38e-10 Cognitive function;Information processing speed; LUSC cis rs17001868 0.568 rs9611316 chr22:40737027 A/G cg07138101 chr22:40742427 ADSL 0.63 7.67 0.39 1.85e-13 Mammographic density (dense area); LUSC cis rs8092503 1.000 rs3764512 chr18:52495324 G/T cg12377874 chr18:52495404 RAB27B 0.33 5.66 0.3 3.32e-8 Childhood body mass index; LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg27535305 chr1:53392650 SCP2 -0.37 -6.89 -0.35 2.83e-11 Monocyte count; LUSC trans rs11098499 0.954 rs11734241 chr4:120416872 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg23690033 chr15:37393574 MEIS2 -0.48 -6.56 -0.34 2.01e-10 Hepatitis; LUSC cis rs3008870 0.959 rs2985826 chr1:67412918 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.26 0.64 2.91e-40 Lymphocyte percentage of white cells; LUSC cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 7.46 0.38 7.65e-13 Colorectal cancer; LUSC cis rs8060686 0.858 rs10468274 chr16:67922342 C/T cg26727032 chr16:67993705 SLC12A4 -0.37 -5.7 -0.3 2.65e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7267979 0.932 rs446649 chr20:25467359 A/G cg08601574 chr20:25228251 PYGB 0.39 5.77 0.3 1.8e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7267979 1.000 rs2297497 chr20:25297909 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.45 -0.33 3.82e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg03352830 chr11:487213 PTDSS2 0.76 8.77 0.43 9.13e-17 Body mass index; LUSC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg22968622 chr17:43663579 NA -0.78 -12.09 -0.55 3.8e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9362426 1.000 rs6930076 chr6:88088654 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.38 6.16 0.32 2.06e-9 Depressive episodes in bipolar disorder; LUSC cis rs9660992 0.626 rs1172113 chr1:205226288 T/C cg21643547 chr1:205240462 TMCC2 -0.48 -9.12 -0.45 7.17e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg04315214 chr1:2043799 PRKCZ 0.46 9.4 0.46 9.12e-19 Height; LUSC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7903847 0.656 rs7895695 chr10:99167255 A/G cg20016023 chr10:99160130 RRP12 0.25 5.65 0.3 3.52e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs12048904 0.964 rs12027668 chr1:101330984 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 7.94 0.4 3e-14 Multiple sclerosis; LUSC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.74 11.02 0.52 2.64e-24 Multiple sclerosis; LUSC cis rs7681440 0.647 rs6814221 chr4:90805501 C/T cg20003494 chr4:90757398 SNCA -0.36 -5.97 -0.31 5.92e-9 Dementia with Lewy bodies; LUSC cis rs7267979 1.000 rs4815420 chr20:25383979 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.01 -0.74 4.09e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9527 0.590 rs1475642 chr10:104546183 C/T cg23093090 chr10:104574429 C10orf26 0.4 6.52 0.34 2.66e-10 Arsenic metabolism; LUSC cis rs12421382 0.558 rs12422001 chr11:109391880 A/G cg27471124 chr11:109292789 C11orf87 0.43 7.46 0.38 7.34e-13 Schizophrenia; LUSC cis rs12903285 1 rs12903285 chr15:78778953 A/G cg18825076 chr15:78729989 IREB2 -0.43 -6.93 -0.35 2.12e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs727505 1.000 rs28392553 chr7:124442944 C/T cg23710748 chr7:124431027 NA -0.41 -7.36 -0.37 1.45e-12 Lewy body disease; LUSC cis rs7980687 0.574 rs10744149 chr12:123708490 T/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Height;Educational attainment;Head circumference (infant); LUSC cis rs7772486 0.806 rs2265477 chr6:146212338 T/C cg23711669 chr6:146136114 FBXO30 0.81 14.85 0.63 1.16e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg22655196 chr4:3374909 RGS12 0.31 5.92 0.31 7.94e-9 Serum sulfate level; LUSC cis rs73001065 0.636 rs28720066 chr19:19572220 G/T cg03709012 chr19:19516395 GATAD2A 0.92 8.49 0.42 6.86e-16 LDL cholesterol; LUSC cis rs2425143 0.818 rs73902932 chr20:34489009 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.69 -0.3 2.77e-8 Blood protein levels; LUSC cis rs12421382 0.614 rs12418763 chr11:109390360 C/T cg11473876 chr11:109292803 C11orf87 0.34 5.72 0.3 2.4e-8 Schizophrenia; LUSC cis rs1355223 0.867 rs11821793 chr11:34681462 A/G cg11058730 chr11:34937778 PDHX;APIP -0.4 -5.65 -0.3 3.53e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg07507251 chr3:52567010 NT5DC2 -0.35 -6.54 -0.34 2.29e-10 Bipolar disorder; LUSC cis rs7189233 1.000 rs16952251 chr16:53483138 A/G cg09728985 chr16:53543985 NA -0.31 -5.7 -0.3 2.64e-8 Intelligence (multi-trait analysis); LUSC trans rs7939886 0.920 rs7950386 chr11:55931513 C/T cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg07716408 chr11:68623521 NA -0.31 -5.96 -0.31 6.4e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6696846 0.630 rs6692706 chr1:205158561 G/T cg21545522 chr1:205238299 TMCC2 0.46 8.55 0.42 4.49e-16 Red blood cell count; LUSC cis rs62400317 0.762 rs10948176 chr6:44833913 A/G cg20913747 chr6:44695427 NA -0.47 -7.31 -0.37 1.96e-12 Total body bone mineral density; LUSC cis rs2836633 1.000 rs2836633 chr21:40067445 C/T cg05519781 chr21:40033154 ERG -0.63 -10.27 -0.49 1.07e-21 Coronary artery disease; LUSC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg17810781 chr1:201082982 CACNA1S 0.35 6.57 0.34 1.98e-10 Permanent tooth development; LUSC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg11494091 chr17:61959527 GH2 0.39 6.8 0.35 4.75e-11 Height; LUSC cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg03146154 chr1:46216737 IPP 0.5 7.43 0.38 9.1e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7829975 0.846 rs1879957 chr8:8544808 T/C cg06636001 chr8:8085503 FLJ10661 -0.56 -8.74 -0.43 1.14e-16 Mood instability; LUSC cis rs11018904 0.906 rs35286339 chr11:89965679 A/G cg26028595 chr11:89956573 CHORDC1 -0.51 -6.14 -0.32 2.39e-9 Intelligence (multi-trait analysis); LUSC cis rs71636778 0.543 rs10493037 chr1:27248645 A/G cg12203394 chr1:27248618 NUDC 0.53 5.65 0.3 3.47e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg08470875 chr2:26401718 FAM59B -0.69 -9.46 -0.46 5.73e-19 Gut microbiome composition (summer); LUSC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg12311346 chr5:56204834 C5orf35 -0.6 -9.35 -0.46 1.29e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs7918232 0.891 rs10443987 chr10:27375377 A/T cg14442939 chr10:27389572 ANKRD26 0.89 10.13 0.48 3.43e-21 Breast cancer; LUSC cis rs4356932 1.000 rs7689664 chr4:76963351 T/A cg00809888 chr4:76862425 NAAA 0.35 5.92 0.31 7.78e-9 Blood protein levels; LUSC trans rs17685 0.712 rs11770149 chr7:75791644 G/A cg19862616 chr7:65841803 NCRNA00174 1.1 18.43 0.71 8.08e-53 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg27446573 chr6:127587934 RNF146 0.92 15.23 0.64 3.94e-40 Breast cancer; LUSC cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg14789911 chr21:47582049 C21orf56 -0.36 -5.72 -0.3 2.39e-8 Testicular germ cell tumor; LUSC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg04369109 chr6:150039330 LATS1 -0.6 -8.67 -0.43 1.93e-16 Lung cancer; LUSC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg18681998 chr4:17616180 MED28 0.85 16.11 0.66 1.26e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11644478 chr21:40555479 PSMG1 -0.77 -13.8 -0.6 1.41e-34 Cognitive function; LUSC trans rs853679 0.517 rs4713145 chr6:28106827 T/C cg06606381 chr12:133084897 FBRSL1 -0.45 -5.96 -0.31 6.36e-9 Depression; LUSC cis rs56283067 0.886 rs56110323 chr6:44679934 G/A cg18551225 chr6:44695536 NA -0.46 -7.9 -0.4 4.18e-14 Total body bone mineral density; LUSC cis rs354225 0.554 rs4374410 chr2:54819088 G/T cg26097391 chr2:54893211 SPTBN1 0.44 6.62 0.34 1.41e-10 Schizophrenia; LUSC cis rs116095464 0.614 rs10059220 chr5:242813 C/T cg22496380 chr5:211416 CCDC127 -0.87 -9.48 -0.46 5.06e-19 Breast cancer; LUSC cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg24130564 chr14:104152367 KLC1 0.49 7.41 0.38 1.08e-12 Intelligence (multi-trait analysis); LUSC cis rs2290416 0.892 rs62523607 chr8:144667432 G/A cg26536354 chr8:144654954 C8orf73 0.67 7.3 0.37 2.18e-12 Attention deficit hyperactivity disorder; LUSC trans rs7939886 0.764 rs11227350 chr11:55912289 T/C cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs6546550 0.867 rs1048266 chr2:70132676 A/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs2439831 0.681 rs540388 chr15:43606494 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.94 11.32 0.53 2.25e-25 Lung cancer in ever smokers; LUSC cis rs6740322 0.793 rs9808360 chr2:43546835 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -7.35 -0.37 1.54e-12 Coronary artery disease; LUSC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.62 13.0 0.58 1.49e-31 Monocyte percentage of white cells; LUSC cis rs4704187 0.687 rs1592948 chr5:74504152 G/A cg03227963 chr5:74354835 NA 0.31 6.76 0.35 6.31e-11 Response to amphetamines; LUSC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg08773314 chr2:239334832 ASB1 0.42 8.91 0.44 3.45e-17 Multiple system atrophy; LUSC cis rs17102884 0.506 rs4899541 chr14:75403437 T/G cg11812906 chr14:75593930 NEK9 -0.42 -6.34 -0.33 7.66e-10 Neuroticism; LUSC cis rs67460515 0.892 rs11711695 chr3:161057593 A/G cg03342759 chr3:160939853 NMD3 -0.51 -7.56 -0.38 3.81e-13 Parkinson's disease; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg11218175 chr11:495084 RNH1 0.53 5.81 0.3 1.44e-8 Body mass index; LUSC cis rs11098499 0.863 rs7695620 chr4:120452776 G/A cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC trans rs62103177 0.564 rs7228971 chr18:77738025 C/T cg14227996 chr4:17616232 MED28 -0.59 -6.34 -0.33 7.49e-10 Opioid sensitivity; LUSC cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs11053261 chr12:34530810 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs8014204 0.566 rs11629369 chr14:75162021 G/A cg06637938 chr14:75390232 RPS6KL1 0.53 8.34 0.42 2.03e-15 Caffeine consumption; LUSC cis rs2354432 0.556 rs66501488 chr1:146853992 T/C cg25205988 chr1:146714368 CHD1L -0.9 -7.58 -0.38 3.38e-13 Mitochondrial DNA levels; LUSC cis rs62400317 0.762 rs12211922 chr6:44847210 A/G cg20913747 chr6:44695427 NA -0.48 -7.43 -0.38 9.13e-13 Total body bone mineral density; LUSC trans rs1325195 0.568 rs17362081 chr1:179092741 A/C cg11624085 chr17:8464688 MYH10 -0.43 -6.54 -0.34 2.27e-10 IgE grass sensitization; LUSC cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg04450456 chr4:17643702 FAM184B 0.4 6.45 0.33 4e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg15383120 chr6:291909 DUSP22 -0.48 -7.45 -0.38 7.86e-13 Menopause (age at onset); LUSC cis rs6430585 0.583 rs2839740 chr2:136648883 G/T cg07169764 chr2:136633963 MCM6 1.2 17.84 0.7 1.71e-50 Corneal structure; LUSC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.33 2.98e-10 Developmental language disorder (linguistic errors); LUSC trans rs2197308 0.740 rs11182251 chr12:37919611 C/T cg06521331 chr12:34319734 NA 0.41 6.45 0.33 3.83e-10 Morning vs. evening chronotype; LUSC cis rs9788682 0.747 rs7174190 chr15:78763617 C/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.97 -0.31 6.23e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -6.61 -0.34 1.56e-10 Longevity;Endometriosis; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg04025307 chr7:1156635 C7orf50 0.44 6.94 0.36 2.04e-11 Longevity;Endometriosis; LUSC cis rs2979489 0.891 rs2915592 chr8:30396417 C/T cg26383811 chr8:30366931 RBPMS -0.51 -8.18 -0.41 6.19e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs7903847 0.620 rs954149 chr10:99122936 G/A cg20016023 chr10:99160130 RRP12 -0.34 -8.21 -0.41 4.79e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.37 5.68 0.3 2.88e-8 Ulcerative colitis; LUSC cis rs25645 0.502 rs9895948 chr17:38108363 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -9.19 -0.45 4.25e-18 Myeloid white cell count; LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg07395648 chr5:131743802 NA -0.4 -6.1 -0.32 2.9e-9 Breast cancer; LUSC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11644478 chr21:40555479 PSMG1 -0.82 -14.95 -0.63 4.93e-39 Cognitive function; LUSC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg25036284 chr2:26402008 FAM59B -0.67 -9.55 -0.46 2.8e-19 Gut microbiome composition (summer); LUSC cis rs10911251 0.508 rs6424890 chr1:183112764 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC trans rs61931739 0.926 rs1995966 chr12:34095420 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.81 -0.39 7.71e-14 Morning vs. evening chronotype; LUSC cis rs72772090 0.634 rs17401901 chr5:96091925 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.74 -8.36 -0.42 1.74e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs9747201 0.926 rs7222764 chr17:80062698 G/A cg07393940 chr7:158741817 NA -0.54 -8.25 -0.41 3.77e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs977987 0.806 rs35937717 chr16:75331567 C/A cg04384234 chr16:75411784 CFDP1 -0.4 -6.52 -0.34 2.66e-10 Dupuytren's disease; LUSC trans rs337939 0.634 rs9542440 chr13:71193499 T/C cg11446651 chr17:27407276 MYO18A -0.35 -6.07 -0.32 3.41e-9 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg11764359 chr7:65958608 NA 0.69 10.69 0.5 3.99e-23 Aortic root size; LUSC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg20573242 chr4:122745356 CCNA2 0.42 6.45 0.33 3.9e-10 Type 2 diabetes; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg19078334 chr9:113019254 TXN -0.57 -6.64 -0.34 1.25e-10 Height; LUSC cis rs6424115 0.830 rs1106 chr1:24200772 C/G cg10978503 chr1:24200527 CNR2 0.54 13.3 0.59 1.11e-32 Immature fraction of reticulocytes; LUSC trans rs4148689 1.000 rs2283057 chr7:117202484 C/G cg10450175 chr16:88689712 ZC3H18 0.46 6.03 0.31 4.38e-9 Gout; LUSC cis rs96067 0.711 rs4653164 chr1:36627542 A/G cg24686825 chr1:36642396 MAP7D1 0.49 7.54 0.38 4.59e-13 Corneal structure; LUSC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg13206674 chr6:150067644 NUP43 0.61 9.77 0.47 5.32e-20 Lung cancer; LUSC cis rs912057 0.526 rs746453 chr6:6734221 C/A cg06612196 chr6:6737390 NA 0.61 12.63 0.57 3.64e-30 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs612683 0.694 rs6688166 chr1:101000717 G/C cg06223162 chr1:101003688 GPR88 0.52 9.57 0.46 2.52e-19 Breast cancer; LUSC cis rs11971779 0.616 rs6944244 chr7:139051186 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9311676 0.609 rs62258133 chr3:58398318 C/G cg13750441 chr3:58318267 PXK 0.35 6.68 0.34 1.02e-10 Systemic lupus erythematosus; LUSC cis rs9905704 0.836 rs12952429 chr17:56843070 C/T cg12560992 chr17:57184187 TRIM37 0.58 8.4 0.42 1.27e-15 Testicular germ cell tumor; LUSC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg07741184 chr6:167504864 NA 0.39 7.03 0.36 1.18e-11 Crohn's disease; LUSC cis rs2806561 0.780 rs4655142 chr1:23333728 T/C cg19743168 chr1:23544995 NA -0.38 -7.94 -0.4 3.07e-14 Height; LUSC cis rs12318506 0.826 rs17804612 chr12:75671271 T/C cg04728562 chr12:75699417 CAPS2 -0.76 -5.95 -0.31 6.65e-9 Coronary artery calcification; LUSC cis rs17604090 0.938 rs28457783 chr7:29687058 T/G cg19413766 chr7:29689036 LOC646762 -0.63 -7.43 -0.38 8.91e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs11051970 0.655 rs10771942 chr12:32528488 G/A cg02745156 chr12:32552066 NA 0.37 6.69 0.34 9.37e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg25072359 chr17:41440525 NA 0.66 9.44 0.46 6.54e-19 Menopause (age at onset); LUSC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg19592336 chr6:28129416 ZNF389 0.47 6.19 0.32 1.75e-9 Parkinson's disease; LUSC cis rs12711979 0.509 rs13021385 chr2:3826387 T/C cg17052675 chr2:3827356 NA -0.82 -19.84 -0.74 1.9e-58 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs524023 0.874 rs495130 chr11:64449307 C/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.61 -0.5 7.33e-23 Urate levels in obese individuals; LUSC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg12963246 chr6:28129442 ZNF389 0.49 6.65 0.34 1.21e-10 Depression; LUSC cis rs713477 0.505 rs1953740 chr14:55886717 G/A cg13175173 chr14:55914753 NA -0.32 -6.0 -0.31 5.1e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs7917772 0.582 rs7907417 chr10:104370662 A/G cg05855489 chr10:104503620 C10orf26 0.47 7.3 0.37 2.08e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs7246967 0.673 rs7245540 chr19:22881504 C/G cg23217946 chr19:22817039 ZNF492 0.42 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs7223966 1.000 rs9912201 chr17:61763208 A/G cg05941027 chr17:61774174 LIMD2 0.22 5.65 0.3 3.4e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs17490626 0.533 rs5030925 chr10:71211150 A/C cg14388049 chr10:71211838 TSPAN15 -0.33 -5.99 -0.31 5.28e-9 Thrombosis; LUSC cis rs3736594 0.918 rs9967838 chr2:27968454 A/C cg27432699 chr2:27873401 GPN1 -0.64 -9.08 -0.45 9.56e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg02038168 chr22:39784481 NA -0.48 -8.0 -0.4 2.09e-14 Intelligence (multi-trait analysis); LUSC trans rs853679 0.505 rs200992 chr6:27814677 A/G cg06606381 chr12:133084897 FBRSL1 -0.83 -8.01 -0.4 1.9e-14 Depression; LUSC trans rs6841433 0.615 rs13147485 chr4:115473477 T/G cg01865118 chr8:29204221 DUSP4 -0.51 -5.97 -0.31 5.93e-9 Hemoglobin concentration; LUSC cis rs7584330 0.657 rs10202292 chr2:238352185 A/T cg14458575 chr2:238380390 NA 0.69 11.77 0.54 5.54e-27 Prostate cancer; LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg10351095 chr21:47802916 PCNT 0.43 6.12 0.32 2.64e-9 Testicular germ cell tumor; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg08888203 chr3:10149979 C3orf24 0.64 9.11 0.45 7.58e-18 Alzheimer's disease; LUSC cis rs7772486 0.875 rs2777477 chr6:146305491 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.9 -0.35 2.69e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.6 0.38 2.92e-13 Vitiligo; LUSC cis rs2692947 0.696 rs2969490 chr2:96803904 A/G cg23100626 chr2:96804247 ASTL 0.26 6.36 0.33 6.53e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2806561 0.765 rs1997866 chr1:23512524 A/G cg19743168 chr1:23544995 NA 0.39 7.68 0.39 1.83e-13 Height; LUSC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg06740227 chr12:86229804 RASSF9 -0.38 -6.16 -0.32 2.1e-9 Major depressive disorder; LUSC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg22920501 chr2:26401640 FAM59B -0.73 -10.73 -0.51 2.84e-23 Gut microbiome composition (summer); LUSC cis rs2404602 0.692 rs4383105 chr15:77055510 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.9 -0.4 4.1e-14 Blood metabolite levels; LUSC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg13393036 chr8:95962371 TP53INP1 -0.34 -6.56 -0.34 2.08e-10 Type 2 diabetes; LUSC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.8 0.39 8.09e-14 Parkinson's disease; LUSC cis rs372883 0.583 rs117214 chr21:30720834 A/G cg08807101 chr21:30365312 RNF160 0.48 7.24 0.37 3.15e-12 Pancreatic cancer; LUSC cis rs6785206 0.892 rs2712429 chr3:128336221 A/C cg16766828 chr3:128327626 NA -0.69 -7.66 -0.39 2.04e-13 Lymphocyte percentage of white cells; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.01 0.31 4.83e-9 Lymphocyte counts; LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg00814883 chr7:100076585 TSC22D4 -0.67 -8.81 -0.43 6.75e-17 Platelet count; LUSC cis rs477692 0.870 rs475250 chr10:131412558 C/G cg05714579 chr10:131428358 MGMT 0.53 8.08 0.4 1.2e-14 Response to temozolomide; LUSC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg12311346 chr5:56204834 C5orf35 -0.88 -12.75 -0.57 1.35e-30 Initial pursuit acceleration; LUSC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg21984481 chr17:79567631 NPLOC4 -0.57 -10.9 -0.51 7.43e-24 Eye color traits; LUSC cis rs10484885 0.824 rs72919982 chr6:90532600 C/G cg13799429 chr6:90582589 CASP8AP2 -0.85 -7.99 -0.4 2.23e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7605827 0.930 rs7586201 chr2:15575735 G/A cg19274914 chr2:15703543 NA 0.48 9.21 0.45 3.65e-18 Educational attainment (years of education); LUSC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg27124370 chr19:33622961 WDR88 0.53 7.59 0.38 3.15e-13 Colorectal cancer; LUSC cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.27 0.59 1.45e-32 Chronic sinus infection; LUSC cis rs72627509 0.857 rs781658 chr4:57779567 G/A cg26694713 chr4:57773883 REST 0.52 6.33 0.33 8.05e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg27494647 chr7:150038898 RARRES2 0.46 7.35 0.37 1.55e-12 Blood protein levels;Circulating chemerin levels; LUSC trans rs61931739 0.500 rs12371415 chr12:34521362 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.35 0.49 5.89e-22 Morning vs. evening chronotype; LUSC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC trans rs2769967 0.624 rs273439 chr9:81917213 C/T cg21715903 chr6:51275527 NA 0.35 6.01 0.31 4.85e-9 Inattentive symptoms; LUSC cis rs861020 1.000 rs674433 chr1:209964875 A/C cg05527609 chr1:210001259 C1orf107 -0.86 -11.96 -0.55 1.07e-27 Orofacial clefts; LUSC cis rs2996428 0.667 rs113120570 chr1:3770450 G/C cg17848003 chr1:3704513 LRRC47 0.32 5.83 0.3 1.32e-8 Red cell distribution width; LUSC cis rs651907 0.712 rs796410 chr3:101610189 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.48 6.82 0.35 4.36e-11 Colorectal cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16739845 chr14:92040772 C14orf184 -0.39 -5.98 -0.31 5.79e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg16339924 chr4:17578868 LAP3 0.55 8.42 0.42 1.11e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs804280 0.543 rs13261205 chr8:11791216 A/G cg21775007 chr8:11205619 TDH 0.46 6.55 0.34 2.18e-10 Myopia (pathological); LUSC cis rs3820068 0.577 rs9728986 chr1:16040603 G/A cg13390004 chr1:15929781 NA 0.41 6.79 0.35 5.02e-11 Systolic blood pressure; LUSC cis rs1728785 0.892 rs4783562 chr16:68562963 A/G cg02972257 chr16:68554789 NA -0.49 -6.3 -0.33 9.24e-10 Ulcerative colitis; LUSC cis rs17253792 0.822 rs75351812 chr14:56082192 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.79 -0.35 5.15e-11 Putamen volume; LUSC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.7 10.79 0.51 1.69e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2108225 0.967 rs6466189 chr7:107448516 C/T cg18560240 chr7:107437656 SLC26A3 -0.39 -5.96 -0.31 6.42e-9 Ulcerative colitis; LUSC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7560272 0.723 rs7585119 chr2:73724679 A/T cg20560298 chr2:73613845 ALMS1 -0.47 -7.23 -0.37 3.3e-12 Schizophrenia; LUSC cis rs1003719 1.000 rs2154536 chr21:38492147 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.67 10.58 0.5 9.48e-23 Eye color traits; LUSC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg18404041 chr3:52824283 ITIH1 -0.42 -7.61 -0.38 2.9e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg18765753 chr7:1198926 ZFAND2A -0.4 -7.29 -0.37 2.29e-12 Longevity;Endometriosis; LUSC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg13175981 chr1:150552382 MCL1 0.5 7.09 0.36 7.86e-12 Tonsillectomy; LUSC cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg03146154 chr1:46216737 IPP 0.55 8.21 0.41 5.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg24549020 chr5:56110836 MAP3K1 0.44 5.95 0.31 6.76e-9 Initial pursuit acceleration; LUSC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg04398451 chr17:18023971 MYO15A -0.46 -7.4 -0.38 1.1e-12 Total body bone mineral density; LUSC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg14664628 chr15:75095509 CSK -0.54 -7.97 -0.4 2.61e-14 Breast cancer; LUSC cis rs10464366 0.746 rs12670510 chr7:39142146 A/G cg10621924 chr7:39171070 POU6F2 0.42 6.26 0.32 1.21e-9 IgG glycosylation; LUSC cis rs11250464 0.755 rs11250468 chr10:1410060 A/G cg08668359 chr10:1443807 ADARB2 0.41 6.2 0.32 1.66e-9 Radiation response; LUSC cis rs2652834 0.851 rs1976433 chr15:63426912 T/G cg05507819 chr15:63340323 TPM1 0.45 5.82 0.3 1.37e-8 HDL cholesterol; LUSC trans rs7829975 0.782 rs6990746 chr8:8547811 A/G cg27411982 chr8:10470053 RP1L1 -0.39 -6.1 -0.32 2.89e-9 Mood instability; LUSC cis rs9527 0.641 rs10786732 chr10:104762535 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.63 0.47 1.54e-19 Arsenic metabolism; LUSC cis rs13082711 0.911 rs923940 chr3:27459341 C/G cg02860705 chr3:27208620 NA 0.49 8.3 0.41 2.69e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs13202913 0.837 rs6906678 chr6:151772395 A/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.65 -5.75 -0.3 2.04e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs2282300 0.637 rs7941828 chr11:30430331 C/T cg25418670 chr11:30344373 C11orf46 -0.4 -6.33 -0.33 8.04e-10 Morning vs. evening chronotype; LUSC cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg17420585 chr12:42539391 GXYLT1 -0.39 -7.66 -0.39 1.99e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4808199 0.947 rs2099333 chr19:19605963 C/T cg03709012 chr19:19516395 GATAD2A 1.12 15.06 0.64 1.78e-39 Nonalcoholic fatty liver disease; LUSC cis rs8062405 0.690 rs4787458 chr16:28531287 A/G cg16576597 chr16:28551801 NUPR1 0.31 6.01 0.31 4.99e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs12210905 0.688 rs12209905 chr6:27404592 C/G cg08851530 chr6:28072375 NA 0.93 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI; LUSC cis rs2404602 0.735 rs437131 chr15:76781051 C/T cg23625390 chr15:77176239 SCAPER 0.53 8.54 0.42 4.89e-16 Blood metabolite levels; LUSC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg06671706 chr8:8559999 CLDN23 0.5 6.68 0.34 9.98e-11 Obesity-related traits; LUSC cis rs1790761 0.607 rs656652 chr11:67343957 C/T cg00290607 chr11:67383545 NA 0.37 6.86 0.35 3.28e-11 Mean corpuscular volume; LUSC cis rs11785693 0.862 rs11774099 chr8:4988218 C/T cg26367366 chr8:4980734 NA 0.77 9.15 0.45 5.72e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC trans rs941408 1.000 rs1640272 chr19:2800192 A/T cg22153745 chr1:153894579 GATAD2B -0.55 -8.61 -0.43 2.85e-16 Total cholesterol levels; LUSC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg14298792 chr15:30685198 CHRFAM7A -0.67 -8.62 -0.43 2.65e-16 Huntington's disease progression; LUSC cis rs7107174 1.000 rs2510054 chr11:77959659 A/G cg02023728 chr11:77925099 USP35 -0.45 -6.7 -0.34 8.67e-11 Testicular germ cell tumor; LUSC cis rs7618501 1.000 rs3749240 chr3:49750188 T/A cg24110177 chr3:50126178 RBM5 0.42 6.66 0.34 1.1e-10 Intelligence (multi-trait analysis); LUSC cis rs9486719 0.947 rs11757102 chr6:96885073 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs6728642 0.908 rs11901495 chr2:98017804 A/G cg26665480 chr2:98280029 ACTR1B 0.66 6.05 0.31 3.93e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg07636037 chr3:49044803 WDR6 1.02 17.51 0.69 3.61e-49 Parkinson's disease; LUSC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg07701084 chr6:150067640 NUP43 0.57 8.88 0.44 4.29e-17 Lung cancer; LUSC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg11608241 chr8:8085544 FLJ10661 0.43 6.37 0.33 6.43e-10 Mood instability; LUSC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg03433033 chr1:76189801 ACADM 0.83 14.35 0.62 1.02e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg15691649 chr6:25882328 NA -0.48 -7.4 -0.38 1.12e-12 Blood metabolite levels; LUSC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg09367891 chr1:107599246 PRMT6 -0.56 -8.69 -0.43 1.71e-16 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.47 8.18 0.41 6.18e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7246657 0.943 rs6508711 chr19:37815134 G/T cg23950597 chr19:37808831 NA -0.65 -7.91 -0.4 3.9e-14 Coronary artery calcification; LUSC cis rs2607426 0.581 rs2604866 chr19:41318757 C/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.81 6.52 0.34 2.64e-10 Blood protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25999486 chr13:76056030 TBC1D4 0.4 6.13 0.32 2.52e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4243830 1.000 rs34757678 chr1:6583270 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.9 8.76 0.43 9.71e-17 Body mass index; LUSC cis rs6480314 1.000 rs6480314 chr10:69967447 G/A cg06988349 chr10:69991859 ATOH7 -0.35 -5.71 -0.3 2.48e-8 Optic nerve measurement (disc area); LUSC cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg26384229 chr12:38710491 ALG10B -0.64 -10.06 -0.48 5.62e-21 Morning vs. evening chronotype; LUSC trans rs12310956 0.510 rs11052882 chr12:33890017 T/C cg13010199 chr12:38710504 ALG10B 0.44 6.8 0.35 4.74e-11 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9398803 0.865 rs1490388 chr6:126835655 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.97e-9 Male-pattern baldness; LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg01879757 chr17:41196368 BRCA1 -0.4 -6.03 -0.31 4.43e-9 Menopause (age at onset); LUSC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg17971929 chr21:40555470 PSMG1 0.56 8.87 0.44 4.54e-17 Cognitive function; LUSC cis rs2230307 0.505 rs641458 chr1:100578672 G/C cg24955406 chr1:100503596 HIAT1 -0.63 -6.68 -0.34 1.01e-10 Carotid intima media thickness; LUSC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg13918804 chr1:2043761 PRKCZ 0.27 5.66 0.3 3.25e-8 Height; LUSC cis rs7512552 0.803 rs3738487 chr1:150477061 C/T cg15654264 chr1:150340011 RPRD2 0.65 10.68 0.5 4.27e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg22800045 chr5:56110881 MAP3K1 0.42 5.71 0.3 2.48e-8 Coronary artery disease; LUSC trans rs7615952 0.688 rs7624806 chr3:125599074 G/A cg07211511 chr3:129823064 LOC729375 -1.16 -17.55 -0.69 2.51e-49 Blood pressure (smoking interaction); LUSC cis rs9039 1.000 rs17652208 chr16:9196463 C/T cg08831531 chr16:9218945 NA -0.69 -10.19 -0.49 2.13e-21 Menopause (age at onset); LUSC cis rs11229555 0.645 rs11229428 chr11:58180382 C/T cg15696309 chr11:58395628 NA -0.64 -7.9 -0.4 4.14e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1878931 0.615 rs6501171 chr16:3402610 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.85 15.86 0.66 1.24e-42 Body mass index (adult); LUSC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1065852 0.510 rs5758666 chr22:42632833 G/A cg00645731 chr22:42541494 CYP2D7P1 0.39 7.0 0.36 1.45e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs1355223 0.573 rs1901830 chr11:34725028 T/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.13 -0.32 2.55e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11648796 0.757 rs6600231 chr16:766485 A/G cg07343612 chr16:622815 PIGQ 0.43 5.88 0.31 9.7e-9 Height; LUSC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg10755058 chr3:40428713 ENTPD3 0.35 5.9 0.31 8.88e-9 Renal cell carcinoma; LUSC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg13206674 chr6:150067644 NUP43 0.57 8.9 0.44 3.66e-17 Lung cancer; LUSC cis rs834811 0.797 rs2633365 chr7:135879797 A/G cg01726295 chr7:135938950 NA 0.39 6.77 0.35 5.85e-11 Post-traumatic stress disorder; LUSC trans rs61931739 0.736 rs7314457 chr12:34454301 G/A cg13010199 chr12:38710504 ALG10B 0.59 9.66 0.47 1.26e-19 Morning vs. evening chronotype; LUSC trans rs9329221 0.662 rs35472251 chr8:10246669 A/G cg15556689 chr8:8085844 FLJ10661 0.62 8.71 0.43 1.39e-16 Neuroticism; LUSC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg02487422 chr3:49467188 NICN1 0.47 7.48 0.38 6.58e-13 Resting heart rate; LUSC cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.41 0.33 5.09e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg22681709 chr2:178499509 PDE11A 0.52 9.38 0.46 1.04e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg08683831 chr4:1404607 NA 0.36 6.11 0.32 2.83e-9 Obesity-related traits; LUSC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg20744362 chr22:50050164 C22orf34 0.4 8.37 0.42 1.64e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9815354 0.812 rs7652506 chr3:42060235 C/T cg03022575 chr3:42003672 ULK4 0.58 6.61 0.34 1.54e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg11062466 chr8:58055876 NA 0.47 6.39 0.33 5.41e-10 Developmental language disorder (linguistic errors); LUSC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg10883421 chr6:151773342 RMND1;C6orf211 0.69 11.5 0.53 5.03e-26 Menarche (age at onset); LUSC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg23158103 chr7:148848205 ZNF398 -0.45 -7.0 -0.36 1.41e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2455601 0.744 rs7938995 chr11:8975675 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.52 -0.34 2.55e-10 Schizophrenia; LUSC cis rs250677 0.916 rs17109279 chr5:148416581 A/G cg23229984 chr5:148520753 ABLIM3 0.38 6.13 0.32 2.54e-9 Breast cancer; LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs400736 0.930 rs408320 chr1:8085328 T/C cg25007680 chr1:8021821 PARK7 0.58 9.11 0.45 7.58e-18 Response to antidepressants and depression; LUSC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg22834771 chr12:69754056 YEATS4 -0.44 -6.3 -0.33 9.42e-10 Blood protein levels; LUSC cis rs12900413 0.687 rs12902786 chr15:90304376 G/A cg24249390 chr15:90295951 MESP1 -0.38 -5.9 -0.31 9.05e-9 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg14539990 chr9:140728301 EHMT1 -0.38 -5.96 -0.31 6.36e-9 Educational attainment (years of education); LUSC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg27170947 chr2:26402098 FAM59B 0.66 9.8 0.47 4.17e-20 Gut microbiome composition (summer); LUSC cis rs2760061 0.583 rs708121 chr1:228208257 A/G cg18477163 chr1:228402036 OBSCN 0.57 9.51 0.46 3.79e-19 Diastolic blood pressure; LUSC cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg13010199 chr12:38710504 ALG10B 0.69 10.65 0.5 5.27e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs614226 0.935 rs7137953 chr12:120894685 C/T cg21053147 chr12:120880522 NA 0.51 6.16 0.32 2.11e-9 Type 1 diabetes nephropathy; LUSC trans rs208520 0.690 rs9345764 chr6:66820597 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.42 -0.69 8.59e-49 Exhaled nitric oxide output; LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs5769707 0.740 rs79946167 chr22:50017556 G/A cg05373962 chr22:49881684 NA -0.39 -9.11 -0.45 7.67e-18 Monocyte count;Monocyte percentage of white cells; LUSC cis rs727505 0.607 rs67454509 chr7:124792500 A/G cg23710748 chr7:124431027 NA -0.39 -6.83 -0.35 4.01e-11 Lewy body disease; LUSC trans rs1015213 0.609 rs117452492 chr8:52817651 A/G cg26618441 chr5:140213825 PCDHA6;PCDHA2;PCDHA1;PCDHA7;PCDHA5;PCDHA3;PCDHA4 -0.87 -6.09 -0.32 3.14e-9 Glaucoma (primary angle closure); LUSC cis rs56161922 0.818 rs55638397 chr1:207856040 G/A cg11752769 chr1:207818423 CR1L -0.69 -5.84 -0.3 1.21e-8 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs8048576 0.512 rs8063863 chr16:84400850 C/T cg03548384 chr16:84403863 ATP2C2 -0.41 -6.26 -0.32 1.2e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6704644 0.719 rs2228939 chr2:234371351 G/A cg05711037 chr2:234359783 DGKD 0.57 5.65 0.3 3.5e-8 Bilirubin levels; LUSC trans rs783147 0.500 rs4252130 chr6:161153080 A/C cg15416064 chr12:49209402 NA -0.47 -6.57 -0.34 1.91e-10 Lp (a) levels; LUSC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg24733560 chr20:60626293 TAF4 0.37 5.91 0.31 8.66e-9 Body mass index; LUSC cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg12310025 chr6:25882481 NA -0.5 -9.06 -0.44 1.09e-17 Blood metabolite levels; LUSC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg02475777 chr4:1388615 CRIPAK 0.43 6.39 0.33 5.68e-10 Obesity-related traits; LUSC cis rs6459788 0.605 rs887628 chr7:157237589 G/A cg06271696 chr7:157225062 NA -0.43 -8.34 -0.42 1.99e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg03806693 chr22:41940476 POLR3H -1.04 -14.94 -0.63 5.08e-39 Vitiligo; LUSC cis rs7917772 0.582 rs10786683 chr10:104320476 G/A cg05855489 chr10:104503620 C10orf26 -0.49 -7.45 -0.38 7.85e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg06784218 chr1:46089804 CCDC17 0.49 9.73 0.47 7.32e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1577917 0.958 rs7739241 chr6:86575796 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.35 -0.42 1.81e-15 Response to antipsychotic treatment; LUSC cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg15744005 chr10:104629667 AS3MT -0.34 -6.95 -0.36 1.92e-11 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs236907 0.859 rs10913684 chr1:171758758 A/G cg13482142 chr2:234261155 NA 0.48 6.05 0.31 3.8e-9 Mean platelet volume; LUSC cis rs734999 0.588 rs2764842 chr1:2529192 A/G cg18932078 chr1:2524107 MMEL1 -0.32 -6.93 -0.35 2.13e-11 Ulcerative colitis; LUSC cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg01849466 chr14:104193079 ZFYVE21 -0.55 -8.76 -0.43 9.98e-17 Schizophrenia; LUSC cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.44 6.89 0.35 2.75e-11 Colorectal cancer; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg07507251 chr3:52567010 NT5DC2 0.33 6.52 0.34 2.55e-10 Bipolar disorder; LUSC cis rs2963155 0.518 rs853176 chr5:142636456 A/G cg17617527 chr5:142782415 NR3C1 -0.72 -8.86 -0.44 4.72e-17 Breast cancer; LUSC trans rs11088226 0.846 rs2154501 chr21:33926451 G/A cg09050820 chr6:167586206 TCP10L2 0.67 10.13 0.48 3.3e-21 Gastritis; LUSC cis rs4853525 0.522 rs1860167 chr2:191582387 G/A cg11845111 chr2:191398756 TMEM194B -0.42 -5.77 -0.3 1.82e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs6121246 0.529 rs112367115 chr20:30178627 G/A cg21427119 chr20:30132790 HM13 -0.44 -5.77 -0.3 1.82e-8 Mean corpuscular hemoglobin; LUSC cis rs1865760 0.516 rs9295684 chr6:26069669 T/C cg17691542 chr6:26056736 HIST1H1C 0.53 8.07 0.4 1.24e-14 Height; LUSC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg22823121 chr1:150693482 HORMAD1 -0.46 -6.85 -0.35 3.47e-11 Tonsillectomy; LUSC cis rs3862435 0.572 rs76176014 chr15:90923962 G/A cg22089800 chr15:90895588 ZNF774 0.59 6.26 0.32 1.21e-9 Response to exercise (triglyceride level interaction); LUSC cis rs11864453 0.713 rs9926156 chr16:72142895 G/C cg23815491 chr16:72088622 HP 0.32 5.71 0.3 2.49e-8 Fibrinogen levels; LUSC cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg00677455 chr12:58241039 CTDSP2 0.69 10.98 0.52 3.62e-24 Multiple sclerosis; LUSC trans rs7647973 0.626 rs7649428 chr3:49868876 A/T cg21659725 chr3:3221576 CRBN 0.69 8.23 0.41 4.34e-15 Menarche (age at onset); LUSC cis rs1808579 0.935 rs1140458 chr18:21119777 G/A cg14672496 chr18:21087552 C18orf8 0.36 6.23 0.32 1.37e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs2070488 0.775 rs6599204 chr3:38525734 C/T cg24069376 chr3:38537580 EXOG 0.42 8.13 0.41 8.32e-15 Electrocardiographic conduction measures; LUSC cis rs9549367 0.713 rs2476319 chr13:113836519 C/T cg00898013 chr13:113819073 PROZ 0.55 8.23 0.41 4.22e-15 Platelet distribution width; LUSC cis rs6089584 0.527 rs927589 chr20:60606363 A/G cg06108461 chr20:60628389 TAF4 -0.74 -11.97 -0.55 1.03e-27 Body mass index; LUSC trans rs7829975 0.711 rs4481596 chr8:8704330 G/C cg27411982 chr8:10470053 RP1L1 0.47 7.52 0.38 5.1e-13 Mood instability; LUSC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.08 -0.32 3.22e-9 Total body bone mineral density; LUSC cis rs7267979 1.000 rs2257420 chr20:25275890 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11190604 1.000 rs7088512 chr10:102303498 G/T cg07080220 chr10:102295463 HIF1AN 0.69 9.5 0.46 4.15e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6681460 1.000 rs1562217 chr1:67073566 C/T cg02459107 chr1:67143332 SGIP1 -0.5 -9.35 -0.46 1.35e-18 Presence of antiphospholipid antibodies; LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg05368731 chr17:41323189 NBR1 0.93 15.74 0.65 3.73e-42 Menopause (age at onset); LUSC cis rs4704187 0.687 rs10058460 chr5:74498715 C/T cg03227963 chr5:74354835 NA 0.31 6.76 0.35 6.31e-11 Response to amphetamines; LUSC cis rs6138458 0.816 rs2151463 chr20:24911819 A/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.94 -0.36 2.02e-11 Blood protein levels; LUSC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg04369109 chr6:150039330 LATS1 -0.55 -8.09 -0.4 1.1e-14 Lung cancer; LUSC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg03676636 chr4:99064102 C4orf37 0.38 8.92 0.44 3.17e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg11764359 chr7:65958608 NA 0.7 10.66 0.5 5e-23 Aortic root size; LUSC cis rs11756438 0.572 rs902779 chr6:119000593 A/C cg18833306 chr6:118973337 C6orf204 0.36 5.79 0.3 1.59e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs8002861 0.935 rs9533672 chr13:44451180 C/T cg12856521 chr11:46389249 DGKZ 0.4 6.29 0.33 1e-9 Leprosy; LUSC cis rs12681287 0.547 rs9942792 chr8:87509046 C/T cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg25456477 chr12:86230367 RASSF9 0.35 6.21 0.32 1.56e-9 Major depressive disorder; LUSC cis rs2288073 0.801 rs10176347 chr2:24367994 G/A cg06627628 chr2:24431161 ITSN2 -0.68 -9.47 -0.46 5.18e-19 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs1577917 0.917 rs13196576 chr6:86534066 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg24060327 chr5:131705240 SLC22A5 -0.52 -8.66 -0.43 2.08e-16 Breast cancer; LUSC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg23978390 chr7:1156363 C7orf50 0.5 5.9 0.31 9.1e-9 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.57 8.31 0.41 2.52e-15 Personality dimensions; LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.98 0.61 2.7e-35 Platelet count; LUSC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg03790207 chr6:42947109 PEX6 -0.46 -6.88 -0.35 2.89e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1847202 0.859 rs6771288 chr3:72939471 A/G cg25664220 chr3:72788482 NA -0.38 -7.01 -0.36 1.3e-11 Motion sickness; LUSC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.38 7.15 0.36 5.66e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg08773314 chr2:239334832 ASB1 0.44 9.54 0.46 3.22e-19 Multiple system atrophy; LUSC cis rs861020 0.771 rs654470 chr1:210014093 A/T cg05527609 chr1:210001259 C1orf107 1.03 15.05 0.64 1.87e-39 Orofacial clefts; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg02951883 chr7:2050386 MAD1L1 -0.62 -12.06 -0.55 4.77e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg06671706 chr8:8559999 CLDN23 0.47 6.4 0.33 5.34e-10 Obesity-related traits; LUSC cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg01028140 chr2:1542097 TPO -0.53 -8.64 -0.43 2.29e-16 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs656319 0.605 rs17747335 chr8:10003186 A/T cg21775007 chr8:11205619 TDH -0.45 -6.28 -0.32 1.03e-9 Myopia (pathological); LUSC trans rs10946292 0.656 rs3012449 chr6:170436735 A/T cg17832364 chr10:94847294 NA 0.38 6.31 0.33 8.63e-10 Obesity-related traits; LUSC trans rs72674100 1.000 rs28417914 chr4:97988227 G/T cg09670535 chr1:18959427 PAX7 -0.56 -6.01 -0.31 4.76e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg23791538 chr6:167370224 RNASET2 0.41 6.7 0.34 8.84e-11 Crohn's disease; LUSC cis rs6469656 0.803 rs6983032 chr8:117705416 C/T cg24004040 chr8:117650383 NA -0.44 -6.44 -0.33 4.13e-10 Colorectal cancer; LUSC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 11.75 0.54 6.47e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9462027 0.606 rs7759227 chr6:34728230 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.74 -0.3 2.08e-8 Systemic lupus erythematosus; LUSC cis rs4631830 0.720 rs2012677 chr10:51504797 T/A cg10326726 chr10:51549505 MSMB -0.35 -6.12 -0.32 2.58e-9 Prostate-specific antigen levels; LUSC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg22875332 chr1:76189707 ACADM -0.85 -14.19 -0.61 4.47e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.04 -0.58 1.08e-31 Alzheimer's disease; LUSC trans rs1994135 0.565 rs11052767 chr12:33731194 A/G cg26384229 chr12:38710491 ALG10B 0.66 9.21 0.45 3.77e-18 Resting heart rate; LUSC cis rs10876993 0.622 rs7978394 chr12:58091695 C/A cg18357645 chr12:58087776 OS9 0.58 8.65 0.43 2.28e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg08280861 chr8:58055591 NA 0.57 6.2 0.32 1.67e-9 Developmental language disorder (linguistic errors); LUSC cis rs2235649 0.623 rs8048162 chr16:1848918 C/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -5.96 -0.31 6.24e-9 Blood metabolite levels; LUSC cis rs9902453 0.934 rs4343336 chr17:28488236 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.19 0.41 5.67e-15 Coffee consumption (cups per day); LUSC cis rs4363385 0.550 rs2050673 chr1:152923698 C/T cg00922841 chr1:152955080 SPRR1A -0.39 -6.4 -0.33 5.27e-10 Inflammatory skin disease; LUSC trans rs10435719 0.902 rs12681142 chr8:11802601 T/C cg08975724 chr8:8085496 FLJ10661 0.46 6.64 0.34 1.26e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs79911532 0.515 rs113056502 chr7:75667901 G/A cg03592824 chr7:75666768 STYXL1 0.7 6.83 0.35 4.03e-11 Mononucleosis; LUSC trans rs6951245 0.935 rs78573577 chr7:1089087 C/A cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs612683 0.602 rs12565245 chr1:101019326 T/G cg06223162 chr1:101003688 GPR88 0.52 9.64 0.47 1.5e-19 Breast cancer; LUSC cis rs9402673 0.558 rs9688342 chr6:135323026 A/T cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Reticulocyte count;High light scatter reticulocyte count; LUSC cis rs9653442 0.900 rs4851269 chr2:100830348 C/T cg22139774 chr2:100720529 AFF3 0.45 8.09 0.4 1.09e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg04865166 chr7:105162814 PUS7 0.51 5.84 0.3 1.25e-8 Bipolar disorder (body mass index interaction); LUSC cis rs8044995 0.563 rs3785116 chr16:68372730 G/A cg05110241 chr16:68378359 PRMT7 -0.82 -8.92 -0.44 3.04e-17 Schizophrenia; LUSC cis rs9837602 1.000 rs7610486 chr3:99732564 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.23 0.32 1.43e-9 Breast cancer; LUSC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg06108461 chr20:60628389 TAF4 -0.97 -16.61 -0.67 1.39e-45 Body mass index; LUSC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.25e-21 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27328858 chr13:74709379 KLF12 0.43 6.0 0.31 5.15e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs73198271 0.740 rs11781430 chr8:8651733 G/C cg01851573 chr8:8652454 MFHAS1 0.52 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg02079420 chr8:82753780 SNX16 0.43 7.37 0.37 1.39e-12 Diastolic blood pressure; LUSC cis rs2996428 0.561 rs2275833 chr1:3745721 C/T cg13057898 chr1:3703894 LRRC47 0.46 7.89 0.4 4.42e-14 Red cell distribution width; LUSC cis rs9303401 0.659 rs34170300 chr17:56789905 G/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs7605827 0.930 rs11682580 chr2:15533272 T/C cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg19748678 chr4:122722346 EXOSC9 0.63 9.58 0.46 2.33e-19 Type 2 diabetes; LUSC cis rs10100465 0.961 rs1383176 chr8:118666943 G/C cg09430518 chr8:118662568 NA -0.3 -5.68 -0.3 2.95e-8 Leprosy; LUSC trans rs800082 0.516 rs1178896 chr3:144240689 A/T cg24215973 chr2:240111563 HDAC4 0.44 6.78 0.35 5.37e-11 Smoking behavior; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg27094323 chr7:1216898 NA -0.47 -8.28 -0.41 2.96e-15 Longevity;Endometriosis; LUSC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg02269571 chr22:50332266 NA -0.57 -8.59 -0.43 3.41e-16 Schizophrenia; LUSC cis rs13256369 0.789 rs13282500 chr8:8568489 A/T cg18904891 chr8:8559673 CLDN23 0.53 7.6 0.38 3.05e-13 Obesity-related traits; LUSC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg12257692 chr3:49977190 RBM6 0.24 6.73 0.35 7.19e-11 Intelligence (multi-trait analysis); LUSC cis rs6427508 1 rs6427508 chr1:160238857 T/C cg07195126 chr1:160370843 VANGL2 0.48 7.37 0.37 1.37e-12 Breast size; LUSC cis rs7923452 0.938 rs34930615 chr10:30761051 G/A cg25182066 chr10:30743637 MAP3K8 0.58 6.94 0.35 2.09e-11 Itch intensity from mosquito bite; LUSC cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg04455712 chr21:45112962 RRP1B 0.47 9.01 0.44 1.67e-17 Mean corpuscular volume; LUSC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg17143192 chr8:8559678 CLDN23 0.66 9.26 0.45 2.46e-18 Obesity-related traits; LUSC cis rs6692729 0.933 rs2236914 chr1:227078721 A/T cg10327440 chr1:227177885 CDC42BPA 0.49 6.88 0.35 2.89e-11 Electrodermal activity; LUSC cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.47 -7.24 -0.37 3.12e-12 Colorectal cancer; LUSC trans rs9929218 1.000 rs28450087 chr16:68803726 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.5 -0.53 5.24e-26 Colorectal cancer; LUSC cis rs12579753 0.789 rs35448307 chr12:82165817 A/G cg21231944 chr12:82153410 PPFIA2 -0.39 -6.16 -0.32 2.07e-9 Resting heart rate; LUSC cis rs7772486 0.654 rs4896829 chr6:145953675 T/A cg23711669 chr6:146136114 FBXO30 0.74 12.94 0.58 2.44e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg06636001 chr8:8085503 FLJ10661 0.65 10.75 0.51 2.35e-23 Mood instability; LUSC cis rs12940923 0.935 rs11871743 chr17:56368825 A/C cg19466818 chr17:56409534 MIR142 -0.39 -6.87 -0.35 3.19e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg27170947 chr2:26402098 FAM59B 0.74 10.86 0.51 9.5e-24 Mean corpuscular hemoglobin; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg11905131 chr22:24372483 LOC391322 -0.53 -8.87 -0.44 4.66e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg11663144 chr21:46675770 NA -0.41 -7.19 -0.37 4.39e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9467773 0.620 rs2451741 chr6:26629404 A/G cg11502198 chr6:26597334 ABT1 0.72 12.06 0.55 4.92e-28 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.525 rs6580891 chr12:39370127 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg13560548 chr3:10150139 C3orf24 0.52 7.25 0.37 2.85e-12 Alzheimer's disease; LUSC trans rs853679 0.607 rs13203816 chr6:28079598 T/C cg06606381 chr12:133084897 FBRSL1 -1.05 -9.08 -0.44 9.63e-18 Depression; LUSC cis rs9430161 0.579 rs11121667 chr1:11038476 C/T cg02454025 chr1:11042201 C1orf127 0.92 17.94 0.7 7.02e-51 Ewing sarcoma; LUSC cis rs7095944 0.614 rs11245354 chr10:126450125 C/A cg08799069 chr10:126477246 METTL10 -0.42 -6.56 -0.34 2.04e-10 Asthma; LUSC cis rs7647973 1.000 rs3448 chr3:49396751 T/C cg07636037 chr3:49044803 WDR6 0.69 9.2 0.45 4.05e-18 Menarche (age at onset); LUSC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg04414720 chr1:150670196 GOLPH3L -0.48 -7.69 -0.39 1.72e-13 Tonsillectomy; LUSC cis rs73001065 0.901 rs3794991 chr19:19610596 C/T cg03709012 chr19:19516395 GATAD2A 0.94 7.27 0.37 2.61e-12 LDL cholesterol; LUSC cis rs9931543 0.714 rs9923469 chr16:56289608 T/C cg00991179 chr16:56000067 NA -0.34 -5.89 -0.31 9.29e-9 Subjective well-being; LUSC cis rs739496 0.542 rs10849937 chr12:111792427 A/G cg10833066 chr12:111807467 FAM109A 0.61 11.82 0.54 3.53e-27 Platelet count; LUSC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg05785598 chr3:49045655 WDR6 0.38 6.48 0.33 3.37e-10 Parkinson's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05874476 chr15:43802882 TP53BP1 0.47 6.42 0.33 4.56e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs55720021 1 rs55720021 chr19:49144241 G/T cg06677660 chr19:49140777 SEC1;DBP 0.44 5.65 0.3 3.45e-8 Lymphocyte percentage of white cells;Neutrophil percentage of white cells; LUSC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg18876405 chr7:65276391 NA 0.59 9.5 0.46 4.06e-19 Aortic root size; LUSC cis rs804280 1.000 rs804281 chr8:11611865 A/G cg00262122 chr8:11665843 FDFT1 0.41 5.9 0.31 9.13e-9 Myopia (pathological); LUSC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg25258033 chr6:167368657 RNASET2 0.46 7.67 0.39 1.91e-13 Crohn's disease; LUSC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg06238570 chr21:40685208 BRWD1 0.54 7.99 0.4 2.18e-14 Cognitive function; LUSC cis rs2281845 0.507 rs7547762 chr1:201088245 A/G cg06714761 chr1:201096289 NA 0.42 7.85 0.39 5.54e-14 Permanent tooth development; LUSC cis rs7577851 0.625 rs72826573 chr2:69567272 C/A cg10773587 chr2:69614142 GFPT1 0.58 6.23 0.32 1.38e-9 Parkinson's disease (age of onset); LUSC cis rs8018808 0.935 rs12433766 chr14:77930293 C/T cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg25703541 chr22:24373054 LOC391322 -0.89 -14.4 -0.62 6.77e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs7582180 0.903 rs2309825 chr2:100905101 A/C cg08017756 chr2:100939284 LONRF2 -0.35 -5.96 -0.31 6.39e-9 Intelligence (multi-trait analysis); LUSC cis rs7189233 0.955 rs8058684 chr16:53515118 G/A cg04059762 chr16:53544020 NA -0.32 -5.79 -0.3 1.67e-8 Intelligence (multi-trait analysis); LUSC cis rs11039100 1.000 rs4474469 chr11:5828849 T/C cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22790142 chr14:24769116 C14orf21;DHRS1 -0.41 -6.0 -0.31 5.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2137920 0.891 rs2254629 chr10:50236629 T/A cg27141751 chr10:50231850 C10orf72 0.38 5.73 0.3 2.28e-8 Migraine with aura; LUSC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg23283495 chr1:209979779 IRF6 0.7 8.25 0.41 3.6e-15 Cleft lip with or without cleft palate; LUSC cis rs7173743 0.784 rs11072811 chr15:79132330 G/T cg00540400 chr15:79124168 NA -0.37 -6.59 -0.34 1.76e-10 Coronary artery disease; LUSC cis rs11785400 0.793 rs9297972 chr8:143723660 C/T cg10596483 chr8:143751796 JRK 0.52 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg12923728 chr3:195709715 SDHAP1 -0.78 -12.23 -0.56 1.15e-28 Pancreatic cancer; LUSC trans rs7580332 0.565 rs4832572 chr2:18540192 A/G cg15951870 chr17:45925060 SP6 -0.34 -6.0 -0.31 5.18e-9 Amyotrophic lateral sclerosis; LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg02018176 chr4:1364513 KIAA1530 0.53 9.24 0.45 2.99e-18 Obesity-related traits; LUSC cis rs41271473 0.526 rs10916343 chr1:228727961 C/T cg16512390 chr1:228756714 NA 0.7 8.89 0.44 4.03e-17 Chronic lymphocytic leukemia; LUSC cis rs72781680 0.784 rs72798406 chr2:24180144 T/C cg08917208 chr2:24149416 ATAD2B 0.61 6.96 0.36 1.82e-11 Lymphocyte counts; LUSC cis rs7267979 1.000 rs2424713 chr20:25418482 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.81 17.57 0.69 2.11e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4664304 1.000 rs4664304 chr2:160794008 A/G cg03641300 chr2:160917029 PLA2R1 -0.39 -6.32 -0.33 8.24e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4851254 0.626 rs71413861 chr2:100673501 A/G cg22139774 chr2:100720529 AFF3 -0.44 -5.82 -0.3 1.37e-8 Intelligence (multi-trait analysis); LUSC cis rs459571 0.959 rs456205 chr9:136911146 G/A cg01294253 chr9:136912663 BRD3 0.35 6.02 0.31 4.69e-9 Platelet distribution width; LUSC cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg23711669 chr6:146136114 FBXO30 0.7 12.18 0.55 1.69e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg23158103 chr7:148848205 ZNF398 -0.44 -7.0 -0.36 1.43e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11644478 chr21:40555479 PSMG1 -0.76 -13.34 -0.59 7.85e-33 Cognitive function; LUSC cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg09367891 chr1:107599246 PRMT6 0.51 7.91 0.4 3.7e-14 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs6964587 1.000 rs12704635 chr7:91737324 T/G cg01689657 chr7:91764605 CYP51A1 0.35 6.3 0.33 9.48e-10 Breast cancer; LUSC cis rs782590 0.582 rs2627767 chr2:55926815 A/T cg18811423 chr2:55921094 PNPT1 0.8 13.04 0.58 1.06e-31 Metabolic syndrome; LUSC cis rs559928 0.606 rs17773078 chr11:63906224 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.19 0.37 4.21e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg17554472 chr22:41940697 POLR3H -0.48 -5.76 -0.3 1.89e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg08888203 chr3:10149979 C3orf24 0.65 9.23 0.45 3.07e-18 Alzheimer's disease; LUSC cis rs10504229 0.680 rs16921675 chr8:58052082 A/G cg11062466 chr8:58055876 NA 0.5 6.81 0.35 4.69e-11 Developmental language disorder (linguistic errors); LUSC cis rs6733011 0.582 rs2280256 chr2:99449174 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.51 -7.3 -0.37 2.12e-12 Bipolar disorder; LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 8.22e-43 Menopause (age at onset); LUSC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.48 7.29 0.37 2.24e-12 Menarche (age at onset); LUSC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg18451016 chr1:38461880 NA -0.5 -6.86 -0.35 3.38e-11 Coronary artery disease; LUSC cis rs1448094 0.872 rs1026085 chr12:86355735 A/G cg02569458 chr12:86230093 RASSF9 0.42 6.68 0.34 9.98e-11 Major depressive disorder; LUSC cis rs9467773 1.000 rs4713008 chr6:26538268 T/C cg11502198 chr6:26597334 ABT1 0.59 9.32 0.45 1.69e-18 Intelligence (multi-trait analysis); LUSC cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.92 0.4 3.59e-14 Colorectal cancer; LUSC cis rs10792830 0.707 rs579406 chr11:85657759 A/C cg07180834 chr11:85838833 NA -0.3 -5.8 -0.3 1.56e-8 Psychosis and Alzheimer's disease; LUSC cis rs4853525 0.522 rs62179715 chr2:191570072 C/T cg11845111 chr2:191398756 TMEM194B -0.43 -5.69 -0.3 2.8e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg13010199 chr12:38710504 ALG10B -0.49 -7.5 -0.38 5.78e-13 Morning vs. evening chronotype; LUSC cis rs7241530 0.689 rs6506735 chr18:75888482 C/T cg14642773 chr18:75888474 NA -0.37 -6.29 -0.33 1.02e-9 Educational attainment (years of education); LUSC cis rs4237845 0.967 rs4553410 chr12:58301211 G/A cg02175503 chr12:58329896 NA 0.65 10.84 0.51 1.12e-23 Intelligence (multi-trait analysis); LUSC cis rs28830936 0.528 rs11630242 chr15:42124643 T/C cg17847044 chr15:42102381 MAPKBP1 -0.38 -9.16 -0.45 5.46e-18 Diastolic blood pressure; LUSC trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg05623727 chr3:50126028 RBM5 -0.35 -6.66 -0.34 1.1e-10 Body mass index; LUSC cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg25427524 chr10:38739819 LOC399744 -0.62 -11.14 -0.52 1e-24 Extrinsic epigenetic age acceleration; LUSC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.39 -0.33 5.72e-10 Lung cancer; LUSC cis rs35264875 0.851 rs7933746 chr11:68867722 A/G cg02660097 chr11:68866761 NA 0.39 6.22 0.32 1.49e-9 Blond vs. brown hair color; LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg20684491 chr1:25596433 NA 0.42 6.6 0.34 1.66e-10 Erythrocyte sedimentation rate; LUSC cis rs11690935 0.632 rs34242651 chr2:172553999 G/A cg13550731 chr2:172543902 DYNC1I2 0.6 9.54 0.46 3.22e-19 Schizophrenia; LUSC cis rs1983891 0.908 rs2148342 chr6:41519522 G/A cg20194872 chr6:41519635 FOXP4 0.33 5.91 0.31 8.35e-9 Prostate cancer; LUSC cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC trans rs1459104 0.925 rs35473011 chr11:54881353 G/A cg03929089 chr4:120376271 NA 0.68 6.03 0.31 4.28e-9 Body mass index; LUSC cis rs4144743 0.877 rs7223766 chr17:45326734 T/G cg18085866 chr17:45331354 ITGB3 -0.75 -7.79 -0.39 8.26e-14 Body mass index; LUSC cis rs10197940 0.510 rs7602715 chr2:152421937 A/G cg19508488 chr2:152266495 RIF1 0.48 6.57 0.34 1.88e-10 Lung cancer; LUSC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.02 -0.31 4.47e-9 Huntington's disease progression; LUSC cis rs9807989 0.507 rs7605284 chr2:103044175 T/G cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.92e-12 Asthma; LUSC cis rs9300255 0.602 rs2851438 chr12:123643689 T/C cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.15 -0.32 2.26e-9 Neutrophil percentage of white cells; LUSC cis rs9905704 0.874 rs304265 chr17:56749298 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.73 0.39 1.28e-13 Testicular germ cell tumor; LUSC cis rs13242816 0.881 rs17138706 chr7:116109019 A/G cg16553024 chr7:116138462 CAV2 -0.54 -5.92 -0.31 7.84e-9 P wave duration; LUSC cis rs738322 0.967 rs133013 chr22:38570912 C/T cg25457927 chr22:38595422 NA -0.42 -8.92 -0.44 3.05e-17 Cutaneous nevi; LUSC cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg16346588 chr10:242978 ZMYND11 -0.43 -5.77 -0.3 1.83e-8 Psychosis in Alzheimer's disease; LUSC cis rs6500395 0.926 rs1039344 chr16:48577569 A/G cg04672837 chr16:48644449 N4BP1 0.43 6.28 0.32 1.05e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1355223 0.583 rs1396880 chr11:34870552 C/T cg24088639 chr11:34937564 PDHX;APIP 0.42 6.25 0.32 1.26e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2486288 0.656 rs2271438 chr15:45557468 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.0 -0.4 2.14e-14 Glomerular filtration rate; LUSC cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg17366294 chr4:99064904 C4orf37 0.54 9.33 0.45 1.47e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 0.842 rs12450766 chr17:56832965 G/C cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.81 -0.3 1.48e-8 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs12980942 1.000 rs34945449 chr19:41819824 T/C cg25627403 chr19:41769009 HNRNPUL1 0.56 6.01 0.31 4.79e-9 Coronary artery disease; LUSC cis rs3105593 0.637 rs3098168 chr15:50751050 T/C cg08437265 chr15:50716283 USP8 0.4 5.9 0.31 8.91e-9 QT interval; LUSC cis rs2273669 0.667 rs12153822 chr6:109315115 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg12463550 chr7:65579703 CRCP -0.47 -7.1 -0.36 7.5e-12 Aortic root size; LUSC cis rs7246967 0.551 rs7257333 chr19:22881149 C/T cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.84 0.75 2.15e-62 Homoarginine levels; LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs79349575 0.691 rs28528789 chr17:46986616 C/T cg22482690 chr17:47019901 SNF8 -0.34 -6.13 -0.32 2.5e-9 Type 2 diabetes; LUSC cis rs7100689 0.577 rs10749550 chr10:82031197 A/G cg00277334 chr10:82204260 NA -0.44 -6.32 -0.33 8.18e-10 Post bronchodilator FEV1; LUSC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.8 9.39 0.46 9.42e-19 Mean platelet volume; LUSC cis rs11758351 0.660 rs77337633 chr6:26233610 T/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs7223966 1.000 rs8075422 chr17:61804686 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.37 0.37 1.37e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg20908204 chr19:46285434 DMPK 0.42 8.32 0.41 2.35e-15 Coronary artery disease; LUSC cis rs12908161 1.000 rs35316992 chr15:85248133 A/G cg12863693 chr15:85201151 NMB 0.42 8.76 0.43 1.02e-16 Schizophrenia; LUSC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg09467607 chr2:36825704 FEZ2 -0.55 -12.69 -0.57 2.18e-30 Height; LUSC cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.15 0.64 7.82e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs7264396 0.635 rs2425166 chr20:34439391 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.65 -0.43 2.19e-16 Total cholesterol levels; LUSC cis rs754466 0.651 rs11002316 chr10:79617511 C/G cg17075019 chr10:79541650 NA -0.74 -11.82 -0.54 3.48e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6987853 0.933 rs2974353 chr8:42409165 A/C cg09913449 chr8:42400586 C8orf40 0.49 8.14 0.41 7.77e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs10880689 1 rs10880689 chr12:37930102 A/G cg26384229 chr12:38710491 ALG10B 0.88 15.08 0.64 1.52e-39 Resting heart rate; LUSC trans rs8072100 0.790 rs11656856 chr17:45714671 C/T cg04995722 chr7:26192034 NFE2L3 0.41 6.41 0.33 5.01e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs877282 0.947 rs957642 chr10:773966 C/T cg17470449 chr10:769945 NA 0.52 7.32 0.37 1.86e-12 Uric acid levels; LUSC cis rs7246967 0.673 rs8102006 chr19:22870103 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs3755132 0.929 rs55668395 chr2:15748423 T/C cg12888861 chr2:15731646 DDX1 0.5 7.3 0.37 2.16e-12 Wilms tumor; LUSC cis rs9392556 0.829 rs7744628 chr6:4119996 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 0.36 6.25 0.32 1.26e-9 Blood metabolite levels; LUSC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg20276088 chr3:133502917 NA 0.44 6.63 0.34 1.38e-10 Iron status biomarkers; LUSC cis rs6582630 0.537 rs8189533 chr12:38391068 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.46 0.65 4.87e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs554111 0.636 rs10916935 chr1:21432112 T/C cg01072550 chr1:21505969 NA 0.38 5.82 0.3 1.41e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs7923609 0.967 rs7095571 chr10:65150959 T/G cg01631684 chr10:65280961 REEP3 -0.4 -6.18 -0.32 1.89e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs1864729 0.688 rs1540434 chr8:98305351 A/G cg08679828 chr8:102218111 ZNF706 -0.79 -6.56 -0.34 2.07e-10 Estradiol plasma levels (breast cancer); LUSC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg11861562 chr11:117069780 TAGLN 0.44 7.92 0.4 3.58e-14 Blood protein levels; LUSC cis rs1150668 0.796 rs213236 chr6:28324397 T/C cg21251018 chr6:28226885 NKAPL 0.33 6.38 0.33 5.97e-10 Pubertal anthropometrics; LUSC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg16928487 chr17:17741425 SREBF1 -0.37 -7.03 -0.36 1.19e-11 Total body bone mineral density; LUSC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg13206674 chr6:150067644 NUP43 0.49 7.34 0.37 1.61e-12 Lung cancer; LUSC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.58e-8 Life satisfaction; LUSC cis rs2303282 0.716 rs7187714 chr16:56467264 A/T cg00500540 chr16:56394104 NA -0.43 -7.38 -0.37 1.27e-12 Breast cancer; LUSC cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.88e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7258465 0.965 rs7253990 chr19:18604085 C/G cg06462663 chr19:18546047 ISYNA1 0.49 8.44 0.42 9.45e-16 Breast cancer; LUSC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg04317338 chr11:64019027 PLCB3 0.66 7.32 0.37 1.89e-12 Mean platelet volume; LUSC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg22823121 chr1:150693482 HORMAD1 0.56 8.05 0.4 1.45e-14 Urate levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21654404 chr12:118814431 SUDS3 -0.48 -6.2 -0.32 1.64e-9 Bipolar disorder and schizophrenia; LUSC trans rs1908814 0.516 rs13281315 chr8:11794855 C/G cg08975724 chr8:8085496 FLJ10661 0.48 6.95 0.36 1.87e-11 Neuroticism; LUSC cis rs2479724 0.591 rs2479726 chr6:41898096 A/G cg17623882 chr6:41773611 USP49 -0.5 -6.59 -0.34 1.73e-10 Menarche (age at onset); LUSC trans rs7647973 0.626 rs62260723 chr3:49872124 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.63 7.44 0.38 8.86e-13 Menarche (age at onset); LUSC cis rs4654899 0.865 rs6693020 chr1:21378057 A/G cg02927042 chr1:21476669 EIF4G3 -0.39 -6.09 -0.32 3.06e-9 Superior frontal gyrus grey matter volume; LUSC trans rs6601327 0.573 rs13278824 chr8:9646119 T/A cg15556689 chr8:8085844 FLJ10661 0.48 7.16 0.36 5.02e-12 Multiple myeloma (hyperdiploidy); LUSC cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.98 0.31 5.76e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg18758796 chr5:131593413 PDLIM4 -0.42 -6.74 -0.35 6.98e-11 Breast cancer; LUSC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg18404041 chr3:52824283 ITIH1 -0.54 -10.26 -0.49 1.23e-21 Electroencephalogram traits; LUSC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg16228356 chr17:43848958 NA -0.28 -6.37 -0.33 6.32e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg22535103 chr8:58192502 C8orf71 -0.67 -7.25 -0.37 2.97e-12 Developmental language disorder (linguistic errors); LUSC cis rs6867032 1.000 rs4246753 chr5:2014721 G/A cg26168224 chr5:2018326 NA 0.81 15.55 0.65 2.06e-41 Gut microbiome composition (winter); LUSC trans rs1997103 1.000 rs12532070 chr7:55407698 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg19482086 chr6:160211437 TCP1;MRPL18 -0.67 -8.7 -0.43 1.59e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs6121246 0.567 rs6060295 chr20:30198473 C/T cg18721089 chr20:30220636 NA -0.37 -5.85 -0.3 1.19e-8 Mean corpuscular hemoglobin; LUSC cis rs11264799 0.581 rs2758680 chr1:157543746 C/T cg18268488 chr1:157545234 FCRL4 0.37 6.91 0.35 2.46e-11 IgA nephropathy; LUSC cis rs68170813 0.559 rs2894459 chr7:106960166 C/T cg02696742 chr7:106810147 HBP1 -0.61 -8.96 -0.44 2.41e-17 Coronary artery disease; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg09177884 chr7:1199841 ZFAND2A -0.43 -6.2 -0.32 1.64e-9 Longevity;Endometriosis; LUSC cis rs6754459 1.000 rs6754459 chr2:3707423 C/T cg10645314 chr2:3704589 ALLC -0.47 -8.0 -0.4 2.08e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9329221 0.686 rs35840352 chr8:10239807 A/G cg27411982 chr8:10470053 RP1L1 0.43 6.27 0.32 1.1e-9 Neuroticism; LUSC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg18306943 chr3:40428807 ENTPD3 0.37 5.76 0.3 1.89e-8 Renal cell carcinoma; LUSC cis rs2414856 0.504 rs72742986 chr15:64987229 T/C cg08069370 chr15:64387884 SNX1 -0.68 -5.9 -0.31 8.97e-9 Pulse pressure;Systolic blood pressure; LUSC cis rs2455601 0.744 rs11042107 chr11:8905871 G/T cg09997546 chr11:8931473 C11orf17;ST5 -0.5 -7.9 -0.4 4.09e-14 Schizophrenia; LUSC cis rs7954584 0.604 rs34159444 chr12:122416667 A/G cg22618164 chr12:122356400 WDR66 0.61 9.03 0.44 1.43e-17 Mean corpuscular volume; LUSC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg21918786 chr6:109611834 NA -0.41 -7.01 -0.36 1.35e-11 Reticulocyte fraction of red cells; LUSC trans rs61931739 0.500 rs56056630 chr12:34543465 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs9807989 0.765 rs6751977 chr2:102967430 T/C cg09003973 chr2:102972529 NA 0.45 6.19 0.32 1.8e-9 Asthma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11237535 chr17:78075184 GAA -0.41 -6.07 -0.32 3.41e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg14893161 chr1:205819251 PM20D1 1.02 24.18 0.8 2.34e-75 Menarche (age at onset); LUSC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg23093090 chr10:104574429 C10orf26 -0.41 -7.33 -0.37 1.72e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3755132 0.929 rs16862822 chr2:15772958 G/A cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs7760535 0.930 rs7742244 chr6:111852662 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.47 -0.33 3.42e-10 Metabolic traits; LUSC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg15664640 chr17:80829946 TBCD -0.72 -13.28 -0.59 1.27e-32 Breast cancer; LUSC cis rs11098499 0.954 rs66506550 chr4:120371445 T/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs3820068 0.532 rs1547034 chr1:15919049 T/A cg13390004 chr1:15929781 NA 0.41 7.06 0.36 9.46e-12 Systolic blood pressure; LUSC cis rs2197308 0.813 rs11504316 chr12:38219320 G/A cg13010199 chr12:38710504 ALG10B -0.48 -7.13 -0.36 6.21e-12 Morning vs. evening chronotype; LUSC cis rs911119 0.955 rs6048933 chr20:23595637 T/G cg16589663 chr20:23618590 CST3 0.61 7.22 0.37 3.62e-12 Chronic kidney disease; LUSC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.35 -0.8 4.97e-76 Height; LUSC cis rs7241530 0.636 rs28491529 chr18:75889301 A/G cg14642773 chr18:75888474 NA 0.36 6.01 0.31 4.91e-9 Educational attainment (years of education); LUSC cis rs6547741 0.967 rs4665986 chr2:27755168 G/A cg12559939 chr2:27858050 GPN1 0.4 6.3 0.33 9.64e-10 Oral cavity cancer; LUSC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.46 -0.38 7.78e-13 Aortic root size; LUSC cis rs453301 0.592 rs4841084 chr8:8883905 C/T cg15556689 chr8:8085844 FLJ10661 0.7 11.28 0.53 3.12e-25 Joint mobility (Beighton score); LUSC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg11812906 chr14:75593930 NEK9 0.66 11.23 0.52 4.9e-25 Height; LUSC cis rs4948275 0.550 rs7082786 chr10:63176990 C/A cg02461363 chr10:63212496 TMEM26 -0.35 -5.7 -0.3 2.69e-8 Night sleep phenotypes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01869960 chr2:136289456 R3HDM1;ZRANB3 -0.46 -6.08 -0.32 3.33e-9 Hepatitis; LUSC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs3820928 0.874 rs1917123 chr2:227889783 T/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.58 -0.38 3.42e-13 Pulmonary function; LUSC cis rs7193541 0.585 rs7978 chr16:74486189 T/C cg01733217 chr16:74700730 RFWD3 -0.87 -16.1 -0.66 1.47e-43 Multiple myeloma; LUSC cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.01 0.4 1.99e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1005224 0.889 rs10132250 chr14:76124380 C/A cg04684003 chr14:76127793 TTLL5;C14orf1 -0.63 -8.65 -0.43 2.25e-16 Large artery stroke; LUSC cis rs12681287 0.546 rs12546802 chr8:87499335 T/A cg27223183 chr8:87520930 FAM82B -0.55 -7.24 -0.37 3.19e-12 Caudate activity during reward; LUSC trans rs9329221 0.537 rs2062332 chr8:9980024 G/A cg21775007 chr8:11205619 TDH 0.45 6.47 0.33 3.41e-10 Neuroticism; LUSC cis rs714027 0.585 rs41170 chr22:30421066 C/T cg11564601 chr22:30592435 NA 0.33 5.82 0.3 1.36e-8 Lymphocyte counts; LUSC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg06481639 chr22:41940642 POLR3H -0.51 -6.14 -0.32 2.41e-9 Vitiligo; LUSC cis rs9457247 0.756 rs2345572 chr6:167403441 A/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.67 -0.34 1.09e-10 Crohn's disease; LUSC trans rs853679 0.607 rs13205211 chr6:28203056 T/G cg06606381 chr12:133084897 FBRSL1 -1.08 -9.49 -0.46 4.57e-19 Depression; LUSC cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg01973587 chr1:228161476 NA 0.44 8.04 0.4 1.62e-14 Diastolic blood pressure; LUSC cis rs9329221 0.618 rs4314693 chr8:10258932 G/T cg21775007 chr8:11205619 TDH -0.53 -7.47 -0.38 7.28e-13 Neuroticism; LUSC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs1371867 0.846 rs1660328 chr8:101303450 A/G cg06636551 chr8:101224915 SPAG1 -0.4 -7.41 -0.38 1.06e-12 Atrioventricular conduction; LUSC cis rs921665 0.749 rs4854133 chr2:3199626 C/T cg02624386 chr2:3182749 NA 0.56 6.12 0.32 2.66e-9 World class endurance athleticism; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg01238044 chr22:24384105 GSTT1 -0.63 -10.14 -0.49 3.05e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs459571 0.959 rs416390 chr9:136908549 C/G cg13789015 chr9:136890014 NCRNA00094 -0.72 -13.41 -0.59 4.11e-33 Platelet distribution width; LUSC cis rs9646944 0.501 rs10210176 chr2:103079516 A/C cg20060108 chr2:102954350 IL1RL1 -0.44 -6.08 -0.32 3.25e-9 Blood protein levels; LUSC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg19468946 chr17:37922297 IKZF3 -0.43 -6.83 -0.35 3.97e-11 Self-reported allergy; LUSC trans rs61931739 0.500 rs11053201 chr12:34453903 T/A cg26384229 chr12:38710491 ALG10B 0.9 15.74 0.65 3.85e-42 Morning vs. evening chronotype; LUSC cis rs1003719 0.613 rs9978998 chr21:38535848 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.56e-22 Eye color traits; LUSC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg09034736 chr1:150693464 HORMAD1 0.4 5.71 0.3 2.5e-8 Melanoma; LUSC cis rs500891 0.525 rs10943930 chr6:84060858 A/T cg08257003 chr6:84140564 ME1 0.34 8.4 0.42 1.33e-15 Platelet-derived growth factor BB levels; LUSC cis rs11992162 0.636 rs4841644 chr8:11798433 A/C cg21775007 chr8:11205619 TDH 0.44 5.96 0.31 6.53e-9 Monocyte count; LUSC cis rs644799 0.511 rs11021301 chr11:95485145 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.67 9.89 0.48 2.13e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs892961 0.932 rs11658267 chr17:75411884 C/T cg05865280 chr17:75406074 SEPT9 -0.43 -9.0 -0.44 1.75e-17 Airflow obstruction; LUSC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg18876405 chr7:65276391 NA -0.65 -11.6 -0.54 2.18e-26 Aortic root size; LUSC cis rs7589342 0.566 rs7589589 chr2:106391154 C/G cg14210321 chr2:106509881 NCK2 -0.43 -6.22 -0.32 1.51e-9 Addiction; LUSC cis rs9372498 0.572 rs62422190 chr6:118909235 A/G cg18833306 chr6:118973337 C6orf204 -0.46 -5.83 -0.3 1.34e-8 Diastolic blood pressure; LUSC cis rs7180079 0.620 rs11071796 chr15:64712608 A/G cg08069370 chr15:64387884 SNX1 0.51 5.64 0.3 3.55e-8 Monocyte count; LUSC cis rs950169 0.881 rs4081123 chr15:84956235 A/G cg12863693 chr15:85201151 NMB 0.36 7.06 0.36 9.44e-12 Schizophrenia; LUSC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg18681998 chr4:17616180 MED28 0.9 17.84 0.7 1.85e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC trans rs60843830 1.000 rs79716074 chr2:277003 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.35 0.49 5.71e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg26769984 chr7:1090371 C7orf50 0.67 9.97 0.48 1.12e-20 Bronchopulmonary dysplasia; LUSC cis rs7804356 1.000 rs61354389 chr7:26868343 C/T cg03456212 chr7:26904342 SKAP2 -0.56 -6.44 -0.33 4.23e-10 Type 1 diabetes; LUSC cis rs9611519 1.000 rs5751069 chr22:41627775 C/G cg03806693 chr22:41940476 POLR3H -0.51 -6.93 -0.35 2.14e-11 Neuroticism; LUSC cis rs10782582 0.593 rs12129523 chr1:76129223 C/A cg03433033 chr1:76189801 ACADM -0.45 -6.78 -0.35 5.41e-11 Daytime sleep phenotypes; LUSC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg03433033 chr1:76189801 ACADM 0.84 15.46 0.65 4.71e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs5009270 0.512 rs1024412 chr7:112247758 A/G cg23628563 chr7:112262597 NA 0.43 6.01 0.31 4.75e-9 Osteoarthritis (hip); LUSC cis rs2841233 0.692 rs2028416 chr14:105348552 C/T cg16576083 chr14:105354267 KIAA0284 0.53 9.57 0.46 2.57e-19 IgG glycosylation; LUSC cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.99 0.31 5.49e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 6.1 0.32 2.9e-9 Tonsillectomy; LUSC cis rs8092503 1.000 rs7231263 chr18:52493167 A/T cg12377874 chr18:52495404 RAB27B -0.31 -5.73 -0.3 2.21e-8 Childhood body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27353073 chr11:76092311 PRKRIR 0.44 6.13 0.32 2.48e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16238933 chr4:668052 ATP5I 0.41 6.52 0.34 2.53e-10 Asthma; LUSC cis rs7769051 0.522 rs6927991 chr6:133113888 T/G cg07930552 chr6:133119739 C6orf192 0.95 8.5 0.42 6.4e-16 Type 2 diabetes nephropathy; LUSC cis rs9902453 1.000 rs4328498 chr17:28344276 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.8 -0.43 7.57e-17 Coffee consumption (cups per day); LUSC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg14403583 chr14:105418241 AHNAK2 -0.58 -9.66 -0.47 1.28e-19 Rheumatoid arthritis; LUSC cis rs4363385 0.818 rs4576617 chr1:152985729 G/A cg00922841 chr1:152955080 SPRR1A -0.42 -7.09 -0.36 7.87e-12 Inflammatory skin disease; LUSC cis rs1691799 0.899 rs1168358 chr12:66748664 A/G cg16791601 chr12:66731901 HELB -0.74 -12.52 -0.57 9.6e-30 White blood cell count (basophil); LUSC cis rs8078723 0.866 rs3935280 chr17:38189055 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.42 6.54 0.34 2.26e-10 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg04518342 chr5:131593106 PDLIM4 0.32 5.72 0.3 2.33e-8 Breast cancer;Mosquito bite size; LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg22920501 chr2:26401640 FAM59B -0.79 -11.76 -0.54 5.97e-27 Gut microbiome composition (summer); LUSC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg06636001 chr8:8085503 FLJ10661 -0.54 -8.45 -0.42 9.17e-16 Neuroticism; LUSC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg15605315 chr1:45957053 TESK2 0.48 7.99 0.4 2.28e-14 High light scatter reticulocyte count; LUSC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg05855489 chr10:104503620 C10orf26 0.59 9.44 0.46 6.45e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.04 -15.92 -0.66 7.51e-43 Gut microbiome composition (summer); LUSC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg27572855 chr1:25598939 RHD 0.41 7.27 0.37 2.55e-12 Erythrocyte sedimentation rate; LUSC cis rs11122272 0.701 rs2491402 chr1:231494338 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.69 -0.47 9.96e-20 Hemoglobin concentration; LUSC cis rs9818941 0.824 rs7427551 chr3:157725242 C/T cg08654915 chr3:157813417 NA -0.31 -7.28 -0.37 2.39e-12 Height; LUSC cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg19628046 chr18:33552617 C18orf21 0.51 6.19 0.32 1.78e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs11997175 0.583 rs4386938 chr8:33673156 A/G ch.8.33884649F chr8:33765107 NA 0.44 6.53 0.34 2.51e-10 Body mass index; LUSC cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.44 0.42 9.92e-16 High light scatter reticulocyte count; LUSC cis rs17270561 0.541 rs12192932 chr6:25911502 A/G cg17691542 chr6:26056736 HIST1H1C 0.98 12.67 0.57 2.66e-30 Iron status biomarkers; LUSC cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -8.14 -0.41 7.95e-15 Bone mineral density; LUSC cis rs7923609 0.934 rs7923544 chr10:65182256 T/G cg01631684 chr10:65280961 REEP3 -0.42 -6.42 -0.33 4.74e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs2295359 0.892 rs72676067 chr1:67658803 G/A cg03340356 chr1:67600835 NA 0.44 6.82 0.35 4.25e-11 Psoriasis; LUSC cis rs6494488 0.500 rs72741315 chr15:64713525 T/C cg08069370 chr15:64387884 SNX1 -0.65 -5.67 -0.3 3.09e-8 Coronary artery disease; LUSC cis rs10080237 0.564 rs2490232 chr6:80814802 C/T cg08355045 chr6:80787529 NA -0.54 -9.73 -0.47 7.12e-20 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg08470875 chr2:26401718 FAM59B 0.74 9.9 0.48 1.99e-20 Gut microbiome composition (summer); LUSC cis rs9311676 0.632 rs62258078 chr3:58363432 G/A cg13750441 chr3:58318267 PXK 0.34 6.63 0.34 1.33e-10 Systemic lupus erythematosus; LUSC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg14440974 chr22:39074834 NA -0.36 -5.92 -0.31 7.79e-9 Menopause (age at onset); LUSC cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg27129171 chr3:47204927 SETD2 -0.7 -11.81 -0.54 4.04e-27 Colorectal cancer; LUSC cis rs7590368 0.715 rs72779466 chr2:10963180 T/A cg15705551 chr2:10952987 PDIA6 0.57 6.24 0.32 1.32e-9 Educational attainment (years of education); LUSC cis rs6831352 0.879 rs7434491 chr4:100069847 G/C cg13256891 chr4:100009986 ADH5 -0.5 -6.47 -0.33 3.53e-10 Alcohol dependence; LUSC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -7.22 -0.37 3.59e-12 Lung cancer; LUSC cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg05340658 chr4:99064831 C4orf37 0.57 9.48 0.46 4.88e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7107174 0.892 rs2510031 chr11:77969956 T/C cg02023728 chr11:77925099 USP35 0.47 7.12 0.36 6.7e-12 Testicular germ cell tumor; LUSC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg00343986 chr7:65444356 GUSB 0.43 6.37 0.33 6.13e-10 Aortic root size; LUSC cis rs9788721 0.900 rs72740964 chr15:78868636 G/A cg18825076 chr15:78729989 IREB2 -0.5 -7.78 -0.39 8.98e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg19468946 chr17:37922297 IKZF3 -0.43 -6.89 -0.35 2.82e-11 Self-reported allergy; LUSC cis rs9815354 1.000 rs6805880 chr3:41865397 A/G cg03022575 chr3:42003672 ULK4 0.59 6.55 0.34 2.2e-10 Pulse pressure;Diastolic blood pressure; LUSC trans rs11098499 0.754 rs9999724 chr4:120239944 C/T cg25214090 chr10:38739885 LOC399744 0.43 6.52 0.34 2.53e-10 Corneal astigmatism; LUSC cis rs7666738 0.546 rs28590002 chr4:98722642 C/T cg03676636 chr4:99064102 C4orf37 0.29 5.69 0.3 2.85e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9790314 0.846 rs6791213 chr3:161033721 A/G cg03342759 chr3:160939853 NMD3 -0.57 -9.69 -0.47 1e-19 Morning vs. evening chronotype; LUSC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00941745 chr8:109261117 EIF3E 0.48 7.63 0.39 2.42e-13 Triglycerides; LUSC cis rs11792861 0.926 rs7856626 chr9:111775502 C/G cg05043794 chr9:111880884 C9orf5 -0.36 -7.71 -0.39 1.42e-13 Menarche (age at onset); LUSC cis rs7180079 0.620 rs6494481 chr15:64849904 G/T cg08069370 chr15:64387884 SNX1 -0.51 -5.75 -0.3 1.97e-8 Monocyte count; LUSC cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.53 0.46 3.45e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12681287 0.640 rs13280468 chr8:87338452 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.29 -0.37 2.29e-12 Caudate activity during reward; LUSC cis rs7605827 0.930 rs2160692 chr2:15637496 C/G cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg01256987 chr12:42539512 GXYLT1 -0.46 -8.92 -0.44 3.05e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1008375 1.000 rs7671752 chr4:17661398 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.75 0.35 6.43e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1018836 0.544 rs2142145 chr8:91460670 A/G cg16814680 chr8:91681699 NA -0.48 -6.87 -0.35 3.24e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1008375 0.900 rs12650220 chr4:17595365 A/T cg18681998 chr4:17616180 MED28 0.83 14.86 0.63 1.03e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12592908 chr6:36954170 MTCH1 -0.45 -5.99 -0.31 5.38e-9 Bipolar disorder and schizophrenia; LUSC cis rs9467711 0.606 rs9366656 chr6:26434630 T/C cg09904177 chr6:26538194 HMGN4 -0.74 -6.85 -0.35 3.47e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs17095355 0.901 rs11194947 chr10:111763731 A/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.33 -0.37 1.79e-12 Biliary atresia; LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg26314531 chr2:26401878 FAM59B -0.67 -8.87 -0.44 4.63e-17 Gut microbiome composition (summer); LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.8 -0.65 2.29e-42 Gut microbiome composition (summer); LUSC cis rs17125944 0.505 rs75194546 chr14:53212069 A/C cg13660082 chr14:53194042 PSMC6 -0.78 -6.82 -0.35 4.38e-11 Alzheimer's disease (late onset); LUSC trans rs12637928 0.580 rs4682589 chr3:110211781 G/A cg17371621 chr15:61264283 RORA 0.36 6.08 0.32 3.29e-9 Neuroticism; LUSC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs7681440 0.904 rs2301135 chr4:90758389 G/C cg01966878 chr4:90757139 SNCA -0.36 -6.21 -0.32 1.61e-9 Dementia with Lewy bodies; LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg19318889 chr4:1322082 MAEA -0.78 -14.57 -0.62 1.39e-37 Longevity; LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.66 0.6 4.84e-34 Platelet count; LUSC cis rs478304 0.934 rs506853 chr11:65521247 C/T cg27068330 chr11:65405492 SIPA1 0.62 9.33 0.45 1.54e-18 Acne (severe); LUSC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg07424592 chr7:64974309 NA 0.69 6.18 0.32 1.88e-9 Diabetic kidney disease; LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg08280861 chr8:58055591 NA 0.53 5.83 0.3 1.31e-8 Developmental language disorder (linguistic errors); LUSC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg11812906 chr14:75593930 NEK9 0.67 11.64 0.54 1.61e-26 Height; LUSC cis rs8048589 0.558 rs35208076 chr16:12228169 C/T cg02910054 chr16:12241554 SNX29 0.46 5.87 0.31 1.03e-8 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg04455712 chr21:45112962 RRP1B 0.45 8.62 0.43 2.73e-16 Mean corpuscular volume; LUSC cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.68 11.42 0.53 1.01e-25 Systemic lupus erythematosus; LUSC cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.39 -0.46 9.83e-19 Schizophrenia; LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg20849893 chr7:64541193 NA -0.65 -5.68 -0.3 2.99e-8 Diabetic kidney disease; LUSC cis rs12476592 0.543 rs1446569 chr2:63818314 C/G cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs6500395 1.000 rs9938633 chr16:48682093 G/C cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.69e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg22875332 chr1:76189707 ACADM 0.74 10.31 0.49 7.84e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.6 0.47 1.95e-19 Bipolar disorder; LUSC cis rs9807841 0.592 rs3810155 chr19:10764867 C/G cg17710535 chr19:10819994 QTRT1 0.41 6.78 0.35 5.45e-11 Inflammatory skin disease; LUSC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg09034736 chr1:150693464 HORMAD1 0.46 6.59 0.34 1.7e-10 Blood protein levels; LUSC cis rs9527 0.521 rs12259163 chr10:104961477 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.02 0.4 1.76e-14 Arsenic metabolism; LUSC cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.69 -9.17 -0.45 4.88e-18 Chronic sinus infection; LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg01802117 chr1:53393560 SCP2 -0.36 -5.95 -0.31 6.76e-9 Monocyte count; LUSC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.79 0.51 1.7e-23 Menopause (age at onset); LUSC cis rs734999 0.545 rs10910111 chr1:2542653 A/G cg18854424 chr1:2615690 NA 0.53 10.87 0.51 9.06e-24 Ulcerative colitis; LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg12016809 chr21:47604291 C21orf56 -0.46 -6.88 -0.35 3.04e-11 Testicular germ cell tumor; LUSC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.0 0.44 1.69e-17 Total body bone mineral density; LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg08132940 chr7:1081526 C7orf50 -0.5 -5.92 -0.31 7.78e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs662064 0.692 rs12129512 chr1:10572967 G/T cg20482658 chr1:10539492 PEX14 0.32 5.92 0.31 7.81e-9 Asthma; LUSC cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14442939 chr10:27389572 ANKRD26 0.96 16.26 0.66 3.22e-44 Breast cancer; LUSC cis rs11690935 0.550 rs4280427 chr2:172813218 G/A cg13550731 chr2:172543902 DYNC1I2 0.48 7.24 0.37 3.11e-12 Schizophrenia; LUSC trans rs450533 0.718 rs440960 chr4:107826866 A/G cg19546012 chr19:752860 C19orf21 -0.31 -5.95 -0.31 6.77e-9 Cancer; LUSC cis rs11098499 0.739 rs10013032 chr4:120149419 C/T cg09307838 chr4:120376055 NA -0.6 -8.85 -0.44 5.24e-17 Corneal astigmatism; LUSC cis rs2625529 0.824 rs11072338 chr15:72245447 T/C cg16672083 chr15:72433130 SENP8 -0.52 -7.65 -0.39 2.1e-13 Red blood cell count; LUSC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg11941060 chr3:133502564 NA 0.53 8.11 0.41 9.96e-15 Iron status biomarkers; LUSC cis rs9378688 0.654 rs2505661 chr6:2326285 G/A cg12303981 chr6:2244766 GMDS -0.41 -5.79 -0.3 1.63e-8 Caudate nucleus volume; LUSC cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs4304924 0.500 rs2281856 chr13:79207644 C/T cg07837209 chr13:79184101 NA 0.45 6.67 0.34 1.05e-10 Large artery stroke; LUSC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg11845111 chr2:191398756 TMEM194B -0.55 -9.21 -0.45 3.76e-18 Pulse pressure; LUSC cis rs9814567 1.000 rs7433663 chr3:134235790 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.7 -0.6 3.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11098499 0.780 rs10013652 chr4:120292256 A/G cg24375607 chr4:120327624 NA 0.69 10.52 0.5 1.56e-22 Corneal astigmatism; LUSC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg06046430 chr4:77819534 ANKRD56 0.49 7.16 0.36 5.01e-12 Emphysema distribution in smoking; LUSC trans rs6982636 0.967 rs2954029 chr8:126490972 A/T cg13325919 chr3:181432053 SOX2;SOX2OT -0.33 -6.27 -0.32 1.13e-9 Lipid metabolism phenotypes; LUSC cis rs2050392 1.000 rs7077496 chr10:30692028 G/A cg18806716 chr10:30721971 MAP3K8 0.45 7.46 0.38 7.6e-13 Inflammatory bowel disease; LUSC cis rs9325144 0.671 rs7485963 chr12:38768254 C/G cg26384229 chr12:38710491 ALG10B -0.61 -9.35 -0.46 1.34e-18 Morning vs. evening chronotype; LUSC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg11764359 chr7:65958608 NA -0.69 -11.11 -0.52 1.25e-24 Aortic root size; LUSC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg18350739 chr11:68623251 NA -0.4 -7.14 -0.36 5.7e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11105298 0.891 rs10777162 chr12:89830523 A/G cg00757033 chr12:89920650 WDR51B 0.59 9.83 0.47 3.49e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs3806843 1.000 rs4404730 chr5:140162610 G/A cg26395211 chr5:140044315 WDR55 -0.37 -5.68 -0.3 2.99e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.33 -0.45 1.47e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.95 -0.4 2.87e-14 Crohn's disease; LUSC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg17252645 chr8:143867129 LY6D 0.37 6.46 0.33 3.67e-10 Urinary tract infection frequency; LUSC cis rs7927592 0.913 rs7127948 chr11:68363062 G/A cg20283391 chr11:68216788 NA -0.61 -8.42 -0.42 1.15e-15 Total body bone mineral density; LUSC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg06718696 chr17:78121285 EIF4A3 0.45 6.4 0.33 5.16e-10 Yeast infection; LUSC trans rs9291683 0.632 rs13137074 chr4:10042842 C/T cg26043149 chr18:55253948 FECH 0.49 7.24 0.37 3.02e-12 Bone mineral density; LUSC trans rs2898290 0.622 rs4840567 chr8:11347625 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.51 -0.42 5.83e-16 Systolic blood pressure; LUSC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg07936489 chr17:37558343 FBXL20 -0.7 -9.59 -0.46 2.05e-19 Glomerular filtration rate (creatinine); LUSC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg03929089 chr4:120376271 NA 0.94 15.05 0.64 1.94e-39 Coronary artery disease; LUSC cis rs4925386 0.681 rs2427294 chr20:60927257 G/A cg22601191 chr20:60968625 CABLES2 0.45 6.29 0.33 9.99e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs9486719 1.000 rs2472880 chr6:96860130 G/A cg06623918 chr6:96969491 KIAA0776 0.79 9.68 0.47 1.1e-19 Migraine;Coronary artery disease; LUSC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg02782426 chr3:40428986 ENTPD3 0.42 7.78 0.39 8.91e-14 Renal cell carcinoma; LUSC cis rs12618769 0.597 rs4851136 chr2:99060873 A/T cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs7178572 0.568 rs1191196 chr15:77646504 C/T cg22256960 chr15:77711686 NA 0.49 7.8 0.39 8.08e-14 Type 2 diabetes; LUSC cis rs936229 0.861 rs3935077 chr15:75120211 C/G cg14664628 chr15:75095509 CSK -1.0 -16.58 -0.67 1.86e-45 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs2562456 0.833 rs1932087 chr19:21521427 G/A cg00806126 chr19:22604979 ZNF98 -0.43 -6.0 -0.31 5.12e-9 Pain; LUSC cis rs6951245 0.678 rs4724725 chr7:1214751 G/A cg03188948 chr7:1209495 NA 0.71 7.58 0.38 3.37e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2439831 1.000 rs2439850 chr15:43784854 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg23711669 chr6:146136114 FBXO30 -0.83 -15.16 -0.64 7.12e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs4474465 0.688 rs7942527 chr11:78280322 A/G cg27205649 chr11:78285834 NARS2 0.59 7.39 0.37 1.23e-12 Alzheimer's disease (survival time); LUSC cis rs34779708 0.966 rs34296409 chr10:35404613 C/G cg03585969 chr10:35415529 CREM 0.62 8.97 0.44 2.2e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1865721 0.771 rs6566093 chr18:73136682 T/C cg26385618 chr18:73139727 C18orf62 -0.55 -10.1 -0.48 4.25e-21 Intelligence; LUSC cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg08999081 chr20:33150536 PIGU -0.54 -10.77 -0.51 2.03e-23 Glomerular filtration rate (creatinine); LUSC cis rs9462027 0.628 rs2815004 chr6:34636268 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.24e-9 Systemic lupus erythematosus; LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg18404041 chr3:52824283 ITIH1 -0.57 -11.01 -0.52 2.85e-24 Bipolar disorder; LUSC cis rs9640161 0.711 rs10259796 chr7:150050427 T/C cg10018233 chr7:150070692 REPIN1 0.35 6.24 0.32 1.31e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs17270561 0.609 rs1185976 chr6:25822363 A/G cg16482183 chr6:26056742 HIST1H1C -0.55 -8.01 -0.4 1.96e-14 Iron status biomarkers; LUSC cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg03146154 chr1:46216737 IPP -0.56 -8.41 -0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs483180 0.512 rs1163251 chr1:120209755 T/C cg19096424 chr1:120255104 PHGDH -0.47 -6.54 -0.34 2.35e-10 Macular telangiectasia type 2; LUSC cis rs9527 0.830 rs12249194 chr10:104643698 T/C cg05855489 chr10:104503620 C10orf26 0.46 6.42 0.33 4.78e-10 Arsenic metabolism; LUSC cis rs6918586 0.681 rs198831 chr6:26116996 T/C cg17691542 chr6:26056736 HIST1H1C 0.39 5.8 0.3 1.57e-8 Schizophrenia; LUSC cis rs31872 0.521 rs246050 chr5:140326860 T/G cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Visceral adipose tissue adjusted for BMI; LUSC cis rs10782582 0.593 rs11579752 chr1:76178694 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.3 -0.33 9.39e-10 Daytime sleep phenotypes; LUSC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg27633287 chr12:130766243 NA -0.32 -6.18 -0.32 1.9e-9 Menopause (age at onset); LUSC cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg18850127 chr7:39170497 POU6F2 0.62 9.41 0.46 8.52e-19 IgG glycosylation; LUSC cis rs4820294 1.000 rs929039 chr22:38071511 T/C cg21798802 chr22:38057573 PDXP 0.48 10.44 0.5 2.77e-22 Fat distribution (HIV); LUSC trans rs2243480 1.000 rs778679 chr7:65840911 A/G cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC trans rs11039798 0.511 rs2047812 chr11:48162042 A/G cg15704280 chr7:45808275 SEPT13 -0.64 -7.12 -0.36 6.59e-12 Axial length; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.47 7.89 0.4 4.5e-14 Lymphocyte counts; LUSC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.08 15.15 0.64 7.97e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9604529 0.532 rs41291213 chr13:114774991 C/T cg12337884 chr13:114819908 RASA3 0.49 6.8 0.35 4.74e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3768617 0.510 rs10911254 chr1:183088627 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg09877947 chr5:131593287 PDLIM4 0.42 6.98 0.36 1.57e-11 Blood metabolite levels; LUSC trans rs61931739 0.500 rs34418276 chr12:34535976 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.42 0.64 7.02e-41 Morning vs. evening chronotype; LUSC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.44 6.24 0.32 1.33e-9 Osteoporosis; LUSC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg13647721 chr17:30228624 UTP6 0.62 6.07 0.32 3.43e-9 Hip circumference adjusted for BMI; LUSC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs7512552 0.839 rs834236 chr1:150362968 C/T cg15654264 chr1:150340011 RPRD2 0.61 10.09 0.48 4.38e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg22823121 chr1:150693482 HORMAD1 0.49 7.05 0.36 1.04e-11 Melanoma; LUSC cis rs12928939 0.815 rs12448022 chr16:71724369 T/C cg03805757 chr16:71968109 PKD1L3 -0.4 -5.93 -0.31 7.44e-9 Post bronchodilator FEV1; LUSC cis rs950169 0.800 rs4842847 chr15:84931199 G/A cg12863693 chr15:85201151 NMB 0.36 7.07 0.36 9.13e-12 Schizophrenia; LUSC cis rs738322 0.967 rs133017 chr22:38572637 A/C cg17652424 chr22:38574118 PLA2G6 -0.3 -6.43 -0.33 4.3e-10 Cutaneous nevi; LUSC cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg01579765 chr21:45077557 HSF2BP -0.51 -10.77 -0.51 2.11e-23 Mean corpuscular volume; LUSC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg19230755 chr7:65878503 NA 0.41 5.75 0.3 2e-8 Aortic root size; LUSC cis rs9341808 0.718 rs4437429 chr6:80828592 A/G cg08355045 chr6:80787529 NA 0.56 9.85 0.47 2.85e-20 Sitting height ratio; LUSC cis rs911555 0.723 rs6575991 chr14:103908433 C/T cg12935359 chr14:103987150 CKB 0.66 10.73 0.51 2.73e-23 Intelligence (multi-trait analysis); LUSC cis rs68092024 0.731 rs792840 chr3:99471251 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.34 -6.15 -0.32 2.25e-9 Cleft lip with or without cleft palate; LUSC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg03804128 chr16:635623 NA 0.33 6.53 0.34 2.4e-10 Height; LUSC cis rs1577917 1.000 rs1911553 chr6:86630892 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.26 -0.41 3.4e-15 Response to antipsychotic treatment; LUSC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg13699009 chr12:122356056 WDR66 0.5 7.72 0.39 1.35e-13 Mean corpuscular volume; LUSC cis rs7577696 0.597 rs7556942 chr2:32295694 G/A cg02381751 chr2:32503542 YIPF4 -0.51 -6.88 -0.35 2.89e-11 Inflammatory biomarkers; LUSC cis rs9399135 0.967 rs9376082 chr6:135346389 T/A cg24558204 chr6:135376177 HBS1L 0.59 9.22 0.45 3.33e-18 Red blood cell count; LUSC cis rs1003719 0.788 rs1155787 chr21:38448069 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.42 0.53 9.82e-26 Eye color traits; LUSC cis rs7712401 0.601 rs30055 chr5:122301079 T/G cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs7084921 0.608 rs12773948 chr10:101865115 T/A cg02250046 chr10:101825185 CPN1 -0.34 -6.24 -0.32 1.32e-9 Bone mineral density; LUSC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg02423579 chr7:2872169 GNA12 -0.44 -6.19 -0.32 1.8e-9 Height; LUSC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg06618935 chr21:46677482 NA -0.29 -5.8 -0.3 1.5e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg05340658 chr4:99064831 C4orf37 0.57 9.41 0.46 8.36e-19 Colonoscopy-negative controls vs population controls; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25291907 chr18:19321706 MIB1 0.77 6.96 0.36 1.78e-11 Cognitive performance; LUSC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg07424592 chr7:64974309 NA 0.66 5.8 0.3 1.55e-8 Diabetic kidney disease; LUSC trans rs1973993 0.967 rs10489741 chr1:96942406 G/A cg10631902 chr5:14652156 NA 0.56 9.76 0.47 5.7e-20 Weight; LUSC cis rs9747201 0.962 rs62078313 chr17:80116708 A/C cg18209359 chr17:80159595 CCDC57 0.39 6.5 0.33 2.99e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs73198271 0.694 rs114184516 chr8:8647082 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.32 -0.33 8.29e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C ch.16.48423040F chr16:49865539 NA 0.4 5.99 0.31 5.45e-9 N-glycan levels; LUSC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg15839431 chr19:19639596 YJEFN3 -0.43 -5.89 -0.31 9.64e-9 Tonsillectomy; LUSC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg13298116 chr11:62369859 EML3;MTA2 -0.51 -7.9 -0.4 4e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3764021 0.870 rs2401391 chr12:9878583 T/C cg20894963 chr12:9885564 CLECL1 0.34 6.95 0.36 1.98e-11 Type 1 diabetes; LUSC cis rs4776059 0.798 rs1080731 chr15:52920658 C/T cg24008177 chr15:52972085 KIAA1370 0.33 6.33 0.33 7.78e-10 Schizophrenia; LUSC cis rs6025261 0.761 rs6092390 chr20:55510339 C/T cg04763273 chr20:55502381 NA 0.33 5.87 0.31 1.05e-8 Verbal memory performance (delayed recall level); LUSC cis rs6430585 0.583 rs76097170 chr2:136593498 C/T cg07169764 chr2:136633963 MCM6 1.16 17.83 0.7 1.99e-50 Corneal structure; LUSC cis rs1983891 1.000 rs4714485 chr6:41536587 T/G cg20194872 chr6:41519635 FOXP4 0.37 6.61 0.34 1.48e-10 Prostate cancer; LUSC trans rs17807624 1.000 rs17807624 chr8:11463015 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.51 -0.38 5.55e-13 Systemic lupus erythematosus; LUSC cis rs73058052 0.935 rs3745474 chr19:50086806 C/T cg09250473 chr19:50168907 IRF3;BCL2L12 0.5 5.78 0.3 1.72e-8 Fibrinogen levels; LUSC cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg13256891 chr4:100009986 ADH5 0.5 7.34 0.37 1.62e-12 Alcohol dependence; LUSC cis rs7666738 0.606 rs10006414 chr4:99101401 T/C cg03676636 chr4:99064102 C4orf37 0.29 6.16 0.32 2.07e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs372883 0.648 rs11088117 chr21:30737816 G/C cg24692254 chr21:30365293 RNF160 0.69 10.78 0.51 1.87e-23 Pancreatic cancer; LUSC cis rs11676348 0.710 rs11894169 chr2:219046846 T/C cg18102446 chr2:218934044 RUFY4 -0.36 -5.75 -0.3 2e-8 Ulcerative colitis; LUSC cis rs4718428 0.662 rs34577323 chr7:66310041 G/C cg18252515 chr7:66147081 NA -0.57 -7.83 -0.39 6.42e-14 Corneal structure; LUSC cis rs9467711 0.651 rs16891261 chr6:26062631 A/G cg21479132 chr6:26055353 NA 0.63 5.84 0.3 1.23e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs12472274 0.648 rs67102443 chr2:239084602 A/G cg17459225 chr2:239074497 NA 0.52 8.66 0.43 2.06e-16 Phospholipid levels (plasma); LUSC trans rs11098499 0.865 rs28845498 chr4:120405186 G/A cg25214090 chr10:38739885 LOC399744 0.54 8.05 0.4 1.44e-14 Corneal astigmatism; LUSC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg18225595 chr11:63971243 STIP1 0.63 10.62 0.5 6.96e-23 Platelet count; LUSC cis rs10740039 0.516 rs9731224 chr10:62343148 G/A cg18175470 chr10:62150864 ANK3 -0.47 -6.98 -0.36 1.62e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg14784868 chr12:69753453 YEATS4 0.91 16.06 0.66 2.01e-43 Cerebrospinal fluid biomarker levels; LUSC cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.78 0.3 1.7e-8 Rheumatoid arthritis; LUSC cis rs9807989 0.839 rs4988958 chr2:102968285 T/C cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg05738196 chr6:26577821 NA -0.5 -6.03 -0.31 4.33e-9 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg02475777 chr4:1388615 CRIPAK -0.42 -6.17 -0.32 1.98e-9 Obesity-related traits; LUSC cis rs7705502 1.000 rs72812817 chr5:173356748 A/G cg18693985 chr5:173351052 CPEB4 -0.38 -6.02 -0.31 4.66e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs11583043 0.793 rs3903905 chr1:101420957 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.2 0.32 1.71e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs939658 1.000 rs8031019 chr15:79458512 C/T cg17916960 chr15:79447300 NA -0.49 -9.82 -0.47 3.67e-20 Refractive error; LUSC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg17948913 chr5:572064 NA 0.38 6.27 0.32 1.09e-9 Obesity-related traits; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.37 0.37 1.34e-12 Prudent dietary pattern; LUSC cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg13010199 chr12:38710504 ALG10B 0.69 11.46 0.53 7.01e-26 Heart rate; LUSC cis rs9549367 0.713 rs9549681 chr13:113829873 T/C cg18105134 chr13:113819100 PROZ -0.76 -10.76 -0.51 2.21e-23 Platelet distribution width; LUSC cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.07 -0.44 1.05e-17 Monocyte percentage of white cells; LUSC cis rs6701037 1.000 rs34493921 chr1:175122759 A/G cg00321850 chr1:175162397 KIAA0040 -0.44 -7.48 -0.38 6.64e-13 Alcohol dependence; LUSC cis rs12310956 0.532 rs1352209 chr12:33983408 G/A cg06521331 chr12:34319734 NA -0.47 -7.55 -0.38 4.09e-13 Morning vs. evening chronotype; LUSC cis rs2797160 0.651 rs6569437 chr6:126034540 T/G cg05901451 chr6:126070800 HEY2 0.77 12.5 0.56 1.13e-29 Endometrial cancer; LUSC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg18876405 chr7:65276391 NA -0.56 -8.81 -0.43 7.03e-17 Aortic root size; LUSC cis rs7598759 0.712 rs10933372 chr2:232332325 G/A cg19187155 chr2:232395269 NMUR1 0.49 7.2 0.37 3.96e-12 Noise-induced hearing loss; LUSC cis rs3740713 0.669 rs113003553 chr11:18410861 T/C cg07915343 chr11:18477680 LDHAL6A -0.46 -5.84 -0.3 1.26e-8 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs57046232 0.552 rs6133306 chr20:6333294 T/G cg17788362 chr6:86352627 SYNCRIP 0.42 5.96 0.31 6.34e-9 Colorectal cancer; LUSC cis rs7615952 0.741 rs13314845 chr3:125644782 C/T cg05084668 chr3:125655381 ALG1L -0.79 -11.95 -0.55 1.26e-27 Blood pressure (smoking interaction); LUSC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg04450456 chr4:17643702 FAM184B 0.37 6.39 0.33 5.7e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17001868 0.568 rs74424549 chr22:40736938 A/C cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.91 -0.51 6.58e-24 Schizophrenia; LUSC cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg06547715 chr2:218990976 CXCR2 0.33 6.49 0.33 3.04e-10 Ulcerative colitis; LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.88 0.48 2.3e-20 Bipolar disorder; LUSC trans rs1792738 0.592 rs1792736 chr18:53849110 A/G cg08471173 chr2:171012543 NA 0.36 6.0 0.31 5.22e-9 Systolic blood pressure (cigarette smoking interaction); LUSC cis rs9611519 0.929 rs13055800 chr22:41440424 G/A cg13813247 chr22:41461852 NA -0.37 -6.75 -0.35 6.38e-11 Neuroticism; LUSC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg26769984 chr7:1090371 C7orf50 0.58 8.06 0.4 1.34e-14 Bronchopulmonary dysplasia; LUSC cis rs6542838 0.641 rs6741166 chr2:99534926 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.53 -7.04 -0.36 1.09e-11 Fear of minor pain; LUSC cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg18351406 chr4:77819688 ANKRD56 0.58 8.31 0.41 2.44e-15 Emphysema distribution in smoking; LUSC cis rs1003719 0.680 rs1034357 chr21:38571482 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg07507251 chr3:52567010 NT5DC2 0.34 6.54 0.34 2.27e-10 Bipolar disorder; LUSC cis rs4776059 1.000 rs11853917 chr15:52922054 T/C cg25063058 chr15:52860530 ARPP19 0.42 5.93 0.31 7.42e-9 Schizophrenia; LUSC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg22963979 chr7:1858916 MAD1L1 -0.59 -8.95 -0.44 2.6e-17 Bipolar disorder and schizophrenia; LUSC trans rs11098499 1.000 rs11098500 chr4:120219239 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.06 0.31 3.73e-9 Corneal astigmatism; LUSC cis rs939574 0.722 rs72955435 chr2:220087354 A/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.9 6.19 0.32 1.72e-9 Platelet distribution width; LUSC trans rs7937682 1.000 rs11608122 chr11:111535105 C/T cg18187862 chr3:45730750 SACM1L -0.52 -6.39 -0.33 5.68e-10 Primary sclerosing cholangitis; LUSC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg19196401 chr6:110721138 DDO -0.46 -8.62 -0.43 2.69e-16 Platelet distribution width; LUSC cis rs9325144 0.647 rs34963631 chr12:38912260 T/A cg13010199 chr12:38710504 ALG10B -0.49 -7.44 -0.38 8.53e-13 Morning vs. evening chronotype; LUSC cis rs3931020 0.657 rs277368 chr1:75230606 C/T cg00121533 chr1:75199117 CRYZ;TYW3 -0.46 -5.79 -0.3 1.62e-8 Resistin levels; LUSC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg18681998 chr4:17616180 MED28 0.85 15.95 0.66 5.78e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2486288 0.656 rs12899058 chr15:45547324 G/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.01 -0.4 1.89e-14 Glomerular filtration rate; LUSC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs67696533 0.600 rs1868385 chr20:31111293 C/T cg13636640 chr20:31349939 DNMT3B 0.48 6.54 0.34 2.38e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg12863693 chr15:85201151 NMB 0.39 8.07 0.4 1.29e-14 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15057251 chr18:32621312 MAPRE2 0.47 6.46 0.33 3.62e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.89 0.31 9.48e-9 Rheumatoid arthritis; LUSC trans rs7951105 0.737 rs12279184 chr11:39251206 T/C cg24085930 chr3:21832523 NA 0.49 6.05 0.31 3.94e-9 Free thyroxine concentration; LUSC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg26380479 chr7:97908229 NA -0.26 -5.88 -0.31 1.02e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs30380 0.666 rs26512 chr5:96128400 G/T cg16492584 chr5:96139282 ERAP1 -0.53 -7.23 -0.37 3.22e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs2688608 0.905 rs2633300 chr10:75656647 A/C cg17411546 chr10:75410026 SYNPO2L -0.46 -6.84 -0.35 3.77e-11 Inflammatory bowel disease; LUSC cis rs7020830 0.858 rs67036212 chr9:37133538 A/G cg14294708 chr9:37120828 ZCCHC7 1.12 24.2 0.8 1.88e-75 Schizophrenia; LUSC cis rs28374715 0.528 rs28492932 chr15:41624397 G/C cg18705301 chr15:41695430 NDUFAF1 -1.07 -22.54 -0.78 4.9e-69 Ulcerative colitis; LUSC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg21770322 chr7:97807741 LMTK2 0.4 6.91 0.35 2.41e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs9388451 0.839 rs3799711 chr6:126075313 C/T cg05039488 chr6:79577232 IRAK1BP1 0.61 9.97 0.48 1.16e-20 Brugada syndrome; LUSC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg13393036 chr8:95962371 TP53INP1 -0.47 -10.34 -0.49 6.17e-22 Type 2 diabetes; LUSC cis rs758324 0.648 rs31474 chr5:131405027 A/G cg14196790 chr5:131705035 SLC22A5 -0.43 -6.31 -0.33 8.91e-10 Alzheimer's disease in APOE e4- carriers; LUSC cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg11062466 chr8:58055876 NA 0.51 6.48 0.33 3.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg10645314 chr2:3704589 ALLC -0.35 -6.13 -0.32 2.43e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs74181299 0.964 rs1009358 chr2:65276452 C/T cg05010058 chr2:65284262 CEP68 -0.31 -6.26 -0.32 1.16e-9 Pulse pressure; LUSC cis rs67460515 0.506 rs935497 chr3:160600563 A/G cg03342759 chr3:160939853 NMD3 -0.41 -6.0 -0.31 5.2e-9 Parkinson's disease; LUSC cis rs11098499 1.000 rs11098499 chr4:120187611 C/T cg24375607 chr4:120327624 NA 0.75 11.23 0.52 4.96e-25 Corneal astigmatism; LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg11843238 chr5:131593191 PDLIM4 0.39 6.53 0.34 2.44e-10 Blood metabolite levels; LUSC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 8.84 0.44 5.69e-17 Menarche (age at onset); LUSC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.14e-30 Aortic root size; LUSC cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.05 0.66 2.2e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7824557 0.564 rs12547100 chr8:11242632 G/A cg21775007 chr8:11205619 TDH -0.69 -10.87 -0.51 8.91e-24 Retinal vascular caliber; LUSC cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg06627628 chr2:24431161 ITSN2 -0.61 -7.4 -0.38 1.09e-12 Lymphocyte counts; LUSC trans rs6561151 0.681 rs7995955 chr13:44434836 C/G cg12856521 chr11:46389249 DGKZ 0.75 9.56 0.46 2.63e-19 Crohn's disease; LUSC cis rs4595586 0.525 rs2892450 chr12:39363678 G/A cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs4919687 0.550 rs7907503 chr10:104440050 C/T cg05855489 chr10:104503620 C10orf26 0.7 11.31 0.53 2.52e-25 Colorectal cancer; LUSC cis rs11229555 0.645 rs12800531 chr11:58180099 C/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg18477163 chr1:228402036 OBSCN -0.56 -10.36 -0.49 5.41e-22 Diastolic blood pressure; LUSC cis rs12220238 1.000 rs10824085 chr10:75911984 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.31 0.37 2.04e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg14895029 chr7:2775587 GNA12 -0.38 -5.82 -0.3 1.4e-8 Height; LUSC cis rs909002 0.800 rs7549590 chr1:32109849 G/A cg01639898 chr1:32083012 HCRTR1 0.32 7.68 0.39 1.8e-13 Intelligence (multi-trait analysis); LUSC cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg08999081 chr20:33150536 PIGU 0.51 10.22 0.49 1.58e-21 Glomerular filtration rate (creatinine); LUSC trans rs11088226 0.801 rs2833886 chr21:33923872 C/A cg09050820 chr6:167586206 TCP10L2 0.65 9.88 0.48 2.28e-20 Gastritis; LUSC cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.13 0.55 2.73e-28 Colorectal cancer; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -12.36 -0.56 3.62e-29 Platelet count; LUSC cis rs7945718 0.775 rs10500759 chr11:12822588 A/G cg25843174 chr11:12811716 TEAD1 -0.31 -7.18 -0.37 4.44e-12 Educational attainment (years of education); LUSC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg12311346 chr5:56204834 C5orf35 -0.63 -9.17 -0.45 5.01e-18 Coronary artery disease; LUSC cis rs11209002 0.695 rs10889653 chr1:67560897 A/G cg02640540 chr1:67518911 SLC35D1 0.66 6.61 0.34 1.5e-10 Crohn's disease; LUSC cis rs2637266 1.000 rs12251434 chr10:78345468 C/A cg18941641 chr10:78392320 NA 0.38 7.07 0.36 8.85e-12 Pulmonary function; LUSC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg06637938 chr14:75390232 RPS6KL1 0.5 7.66 0.39 2.02e-13 Height; LUSC cis rs1055129 0.537 rs2467100 chr17:73949038 C/G cg17515076 chr17:73810948 UNK -0.37 -6.22 -0.32 1.52e-9 White matter hyperintensity burden; LUSC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg18357526 chr6:26021779 HIST1H4A 0.4 6.3 0.33 9.2e-10 Intelligence (multi-trait analysis); LUSC cis rs6714710 0.603 rs17489984 chr2:98421364 A/G cg26665480 chr2:98280029 ACTR1B 0.61 8.91 0.44 3.25e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6840360 1.000 rs6834095 chr4:152603278 C/T cg22705602 chr4:152727874 NA -0.28 -5.91 -0.31 8.54e-9 Intelligence (multi-trait analysis); LUSC cis rs62027291 1.000 rs112503392 chr15:77275646 C/T cg26408565 chr15:76604113 ETFA 0.54 6.4 0.33 5.37e-10 Plateletcrit; LUSC cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg20701182 chr2:24300061 SF3B14 0.89 11.69 0.54 1.08e-26 Lymphocyte counts; LUSC cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg08508325 chr11:3079039 CARS -0.48 -11.12 -0.52 1.16e-24 Type 2 diabetes; LUSC cis rs6690583 0.623 rs893620 chr1:85425821 T/C cg22153463 chr1:85462885 MCOLN2 0.64 6.08 0.32 3.37e-9 Serum sulfate level; LUSC trans rs9784649 1.000 rs3933895 chr5:25004929 A/T cg08600765 chr20:34638493 LOC647979 -0.55 -6.45 -0.33 4.01e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7599312 0.534 rs7607363 chr2:213402705 A/G cg16329650 chr2:213403929 ERBB4 0.86 18.45 0.71 6.91e-53 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9640161 0.750 rs3735169 chr7:150034378 A/G cg21361702 chr7:150065534 REPIN1 0.49 6.4 0.33 5.3e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.04 21.51 0.76 5.11e-65 Height; LUSC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg04362960 chr10:104952993 NT5C2 -0.61 -9.57 -0.46 2.45e-19 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4242434 0.819 rs751680 chr8:22475627 G/A cg03733263 chr8:22462867 KIAA1967 0.89 15.6 0.65 1.36e-41 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.22 -0.37 3.57e-12 Major depressive disorder; LUSC trans rs11098499 0.691 rs9996494 chr4:120238880 C/A cg25214090 chr10:38739885 LOC399744 0.43 6.41 0.33 5.04e-10 Corneal astigmatism; LUSC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg17724175 chr1:150552817 MCL1 0.37 6.77 0.35 5.97e-11 Tonsillectomy; LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.16 0.52 8.67e-25 Menopause (age at onset); LUSC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg12658694 chr1:38397304 INPP5B -0.49 -6.53 -0.34 2.52e-10 Coronary artery disease; LUSC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg04414720 chr1:150670196 GOLPH3L 0.51 8.0 0.4 2.08e-14 Melanoma; LUSC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.69 -0.3 2.79e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg11645453 chr3:52864694 ITIH4 0.4 8.71 0.43 1.4e-16 Bipolar disorder; LUSC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg22535103 chr8:58192502 C8orf71 -0.57 -6.74 -0.35 6.81e-11 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.657 rs7664458 chr4:120371967 A/G cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg24110177 chr3:50126178 RBM5 -0.55 -9.05 -0.44 1.22e-17 Intelligence (multi-trait analysis); LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg22638593 chr5:131593259 PDLIM4 0.44 6.28 0.33 1.05e-9 Acylcarnitine levels; LUSC cis rs12464483 0.524 rs2256411 chr2:30886860 C/A cg17749961 chr2:30669863 LCLAT1 0.62 7.33 0.37 1.76e-12 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg14416269 chr4:6271139 WFS1 0.54 11.4 0.53 1.2e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2540226 1.000 rs2540226 chr2:39959060 G/T cg23576258 chr2:39999331 THUMPD2 -0.34 -5.81 -0.3 1.45e-8 Personality dimensions; LUSC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg11764359 chr7:65958608 NA -0.78 -12.81 -0.57 7.69e-31 Aortic root size; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.66 0.34 1.15e-10 Menopause (age at onset); LUSC trans rs3749237 1.000 rs6804655 chr3:49738945 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.52 7.23 0.37 3.22e-12 Resting heart rate; LUSC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg06618935 chr21:46677482 NA -0.39 -7.97 -0.4 2.48e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.78e-10 Reticulocyte fraction of red cells; LUSC cis rs7621025 0.500 rs1965107 chr3:136648643 T/A cg15507776 chr3:136538369 TMEM22 0.61 8.42 0.42 1.13e-15 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs9443189 0.570 rs504446 chr6:76326939 T/C cg01950844 chr6:76311363 SENP6 0.7 7.02 0.36 1.26e-11 Prostate cancer; LUSC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg23791538 chr6:167370224 RNASET2 -0.41 -6.77 -0.35 5.65e-11 Crohn's disease; LUSC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg14440974 chr22:39074834 NA -0.38 -6.2 -0.32 1.69e-9 Menopause (age at onset); LUSC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg11941060 chr3:133502564 NA -0.52 -8.0 -0.4 2.11e-14 Iron status biomarkers; LUSC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg19046167 chr17:80928561 B3GNTL1 -0.46 -7.51 -0.38 5.42e-13 Breast cancer; LUSC cis rs977987 0.806 rs12924920 chr16:75440133 G/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.79e-10 Dupuytren's disease; LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25951256 chr10:38645740 HSD17B7P2 -0.41 -5.97 -0.31 6.17e-9 Breast cancer; LUSC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg25427524 chr10:38739819 LOC399744 -0.74 -14.08 -0.61 1.14e-35 Extrinsic epigenetic age acceleration; LUSC cis rs909002 0.830 rs10914461 chr1:32113217 G/A cg01639898 chr1:32083012 HCRTR1 0.3 7.38 0.37 1.3e-12 Intelligence (multi-trait analysis); LUSC cis rs2172802 0.659 rs2343251 chr4:62492671 C/A cg04118610 chr4:62707027 LPHN3 0.45 6.1 0.32 2.97e-9 Partial epilepsies; LUSC cis rs8050755 0.649 rs2516737 chr16:2101749 A/G cg04515572 chr16:2107413 TSC2 0.69 6.94 0.35 2.09e-11 Major depressive disorder; LUSC cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.28 0.45 2.14e-18 Motion sickness; LUSC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg14668632 chr7:2872130 GNA12 -0.49 -7.24 -0.37 3.17e-12 Height; LUSC cis rs7605827 0.930 rs1024870 chr2:15625846 T/C cg19274914 chr2:15703543 NA 0.46 8.82 0.43 6.51e-17 Educational attainment (years of education); LUSC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs9921338 0.961 rs56136462 chr16:11415595 A/G cg00044050 chr16:11439710 C16orf75 -0.5 -6.73 -0.35 7.37e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 7.83 0.39 6.71e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6665290 0.868 rs2183836 chr1:227199404 A/T cg10327440 chr1:227177885 CDC42BPA -1.21 -34.56 -0.88 2.43e-112 Myeloid white cell count; LUSC cis rs231513 0.769 rs537169 chr17:41976740 G/A cg26893861 chr17:41843967 DUSP3 -0.51 -6.06 -0.31 3.74e-9 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04079722 chr16:30569728 ZNF764 -0.42 -6.08 -0.32 3.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14685339 chr14:77787351 POMT2;GSTZ1 0.48 6.66 0.34 1.13e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg03146154 chr1:46216737 IPP 0.5 7.44 0.38 8.46e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10203711 0.933 rs7584327 chr2:239584203 A/T cg14580085 chr2:239553406 NA 0.39 6.47 0.33 3.56e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs76878669 0.538 rs2282530 chr11:66177952 C/T cg18002602 chr11:66138449 SLC29A2 -0.49 -8.64 -0.43 2.38e-16 Educational attainment (years of education); LUSC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg18240062 chr17:79603768 NPLOC4 0.71 12.97 0.58 1.96e-31 Eye color traits; LUSC cis rs6691722 0.506 rs1016209 chr1:24745615 A/G cg02336364 chr1:24764700 NIPAL3 -0.33 -5.92 -0.31 8.05e-9 Response to interferon beta in multiple sclerosis; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg13047869 chr3:10149882 C3orf24 0.55 7.84 0.39 6.12e-14 Alzheimer's disease; LUSC cis rs9527 0.662 rs4919687 chr10:104595248 G/A cg05855489 chr10:104503620 C10orf26 0.62 8.91 0.44 3.28e-17 Arsenic metabolism; LUSC trans rs11098499 0.820 rs2389885 chr4:120533931 C/T cg25214090 chr10:38739885 LOC399744 0.52 7.56 0.38 3.94e-13 Corneal astigmatism; LUSC trans rs7726839 0.561 rs72703058 chr5:584519 G/A cg11887960 chr12:57824829 NA 0.48 6.47 0.33 3.46e-10 Obesity-related traits; LUSC cis rs9473147 0.516 rs9349416 chr6:47551938 G/A cg20196966 chr6:47445060 CD2AP 0.41 5.75 0.3 2.07e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7954584 0.567 rs11043233 chr12:122330733 C/T cg21016266 chr12:122356598 WDR66 0.62 9.42 0.46 7.85e-19 Mean corpuscular volume; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg24675658 chr1:53192096 ZYG11B -0.7 -11.74 -0.54 7.34e-27 Monocyte count; LUSC cis rs1729951 0.575 rs361241 chr3:136699561 C/A cg21827317 chr3:136751795 NA 0.38 6.78 0.35 5.46e-11 Neuroticism; LUSC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs9911578 0.835 rs2301867 chr17:56480074 T/A cg12560992 chr17:57184187 TRIM37 -0.71 -12.61 -0.57 4.42e-30 Intelligence (multi-trait analysis); LUSC cis rs10791097 0.967 rs10750450 chr11:130719061 G/T cg12179176 chr11:130786555 SNX19 0.77 13.32 0.59 8.95e-33 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06387980 chr19:17416471 MRPL34 0.76 6.49 0.33 3.15e-10 Cognitive performance; LUSC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs10266483 0.774 rs28580000 chr7:63801909 A/G cg24201672 chr7:64023550 ZNF680 0.44 5.8 0.3 1.53e-8 Response to statin therapy; LUSC cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg16339924 chr4:17578868 LAP3 0.64 10.17 0.49 2.39e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2280018 0.538 rs7404526 chr16:15129162 A/G cg07549590 chr16:15018862 NA -0.44 -7.26 -0.37 2.71e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10022260 1 rs10022260 chr4:83793921 C/T cg00595051 chr4:83955429 COPS4 -0.4 -6.79 -0.35 5.18e-11 Adult asthma; LUSC cis rs911119 0.818 rs56077567 chr20:23591087 T/C cg16589663 chr20:23618590 CST3 0.57 6.79 0.35 5.12e-11 Chronic kidney disease; LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs7939886 0.920 rs7113835 chr11:55947007 C/T cg15704280 chr7:45808275 SEPT13 0.89 6.88 0.35 3e-11 Myopia (pathological); LUSC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.83 0.47 3.52e-20 Major depressive disorder; LUSC cis rs9650315 0.706 rs11985751 chr8:57137439 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.55 7.45 0.38 7.9e-13 Height; LUSC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg21573476 chr21:45109991 RRP1B -0.43 -6.89 -0.35 2.71e-11 Mean corpuscular volume; LUSC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg25039879 chr17:56429692 SUPT4H1 0.72 9.79 0.47 4.62e-20 Cognitive test performance; LUSC cis rs10497399 0.730 rs7558967 chr2:174111412 C/T cg22854985 chr2:174082101 ZAK -0.51 -5.96 -0.31 6.27e-9 Adiponectin levels; LUSC cis rs4363385 0.747 rs1415971 chr1:152965779 T/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.66 -0.39 2.08e-13 Inflammatory skin disease; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg27284194 chr4:1044797 NA 0.34 5.84 0.3 1.22e-8 Obesity-related traits; LUSC trans rs61931739 1.000 rs11052967 chr12:34020030 T/G cg26384229 chr12:38710491 ALG10B -0.52 -7.94 -0.4 3.04e-14 Morning vs. evening chronotype; LUSC trans rs921968 0.643 rs4674305 chr2:219293326 C/T cg17343622 chr17:76704594 CYTH1 -0.4 -6.26 -0.32 1.15e-9 Mean corpuscular hemoglobin concentration; LUSC cis rs3020736 0.500 rs5996111 chr22:42493902 C/T cg05082376 chr22:42548792 NA 0.42 6.21 0.32 1.58e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg07167872 chr1:205819463 PM20D1 -0.88 -17.2 -0.69 6.43e-48 Menarche (age at onset); LUSC cis rs9287719 0.967 rs4555318 chr2:10744295 C/G cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs6121246 0.542 rs6059761 chr20:30110522 G/C cg21427119 chr20:30132790 HM13 -0.47 -6.9 -0.35 2.59e-11 Mean corpuscular hemoglobin; LUSC cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg13256891 chr4:100009986 ADH5 0.48 7.11 0.36 7.05e-12 Alcohol dependence; LUSC trans rs11098499 0.863 rs10018280 chr4:120478139 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.75e-10 Corneal astigmatism; LUSC cis rs12188164 0.515 rs2672744 chr5:411047 A/G cg00049323 chr5:472564 LOC25845 0.39 5.98 0.31 5.61e-9 Cystic fibrosis severity; LUSC trans rs225245 0.755 rs6505491 chr17:34026335 A/G cg19694781 chr19:47549865 TMEM160 -0.39 -6.2 -0.32 1.67e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs11250098 0.526 rs116793410 chr8:10770255 G/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.23 -0.37 3.28e-12 Morning vs. evening chronotype; LUSC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg11244672 chr19:19639970 YJEFN3 -0.58 -7.38 -0.37 1.27e-12 Bipolar disorder; LUSC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.72 -0.47 7.99e-20 Gut microbiome composition (summer); LUSC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg13770153 chr20:60521292 NA -0.43 -6.02 -0.31 4.63e-9 Body mass index; LUSC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg02753203 chr1:228287806 NA 0.73 12.91 0.58 3.34e-31 Diastolic blood pressure; LUSC cis rs12908161 0.959 rs12906348 chr15:85329421 A/C cg17173187 chr15:85201210 NMB 0.48 8.78 0.43 8.71e-17 Schizophrenia; LUSC trans rs7100689 0.646 rs1290317 chr10:82062531 C/A cg07663200 chr17:42030104 NA -0.37 -6.17 -0.32 1.99e-9 Post bronchodilator FEV1; LUSC cis rs9486719 1.000 rs12207570 chr6:96987884 A/C cg06623918 chr6:96969491 KIAA0776 -0.78 -10.09 -0.48 4.66e-21 Migraine;Coronary artery disease; LUSC cis rs9473147 0.516 rs10456570 chr6:47559451 A/G cg12968598 chr6:47444699 CD2AP 0.52 7.93 0.4 3.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs8060686 0.641 rs2418737 chr16:68122726 T/C cg05110241 chr16:68378359 PRMT7 -0.51 -6.14 -0.32 2.37e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg15423357 chr2:25149977 NA 0.43 8.63 0.43 2.53e-16 Body mass index; LUSC cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg13319975 chr6:146136371 FBXO30 -0.53 -8.05 -0.4 1.5e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23137483 chr22:41682341 RANGAP1 0.46 6.46 0.33 3.6e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10791323 0.536 rs1944731 chr11:133726067 G/A cg00579200 chr11:133705235 NA -0.4 -5.98 -0.31 5.83e-9 Childhood ear infection; LUSC cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.81 -12.88 -0.58 4.15e-31 Chronic sinus infection; LUSC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11644478 chr21:40555479 PSMG1 0.93 17.67 0.7 8.11e-50 Cognitive function; LUSC trans rs6951245 1.000 rs77305932 chr7:1100861 T/A cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg12516959 chr21:47718080 NA 0.35 5.67 0.3 3.1e-8 Testicular germ cell tumor; LUSC cis rs17685 0.816 rs11763076 chr7:75765963 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.3e-11 Monocyte count; LUSC cis rs2742417 0.967 rs2742441 chr3:45748429 G/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.48e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg27588902 chr6:42928151 GNMT -0.3 -6.55 -0.34 2.24e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11190604 1.000 rs10786597 chr10:102291287 C/T cg23241863 chr10:102295624 HIF1AN 0.48 5.74 0.3 2.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg08859206 chr1:53392774 SCP2 -0.56 -9.64 -0.47 1.48e-19 Monocyte count; LUSC cis rs2806561 0.664 rs4620508 chr1:23307438 C/T cg12483005 chr1:23474871 LUZP1 0.42 6.18 0.32 1.84e-9 Height; LUSC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg21153622 chr11:89784906 NA -0.46 -7.19 -0.37 4.37e-12 Coronary artery disease; LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg04518342 chr5:131593106 PDLIM4 -0.52 -9.42 -0.46 7.49e-19 Acylcarnitine levels; LUSC cis rs12911832 1.000 rs4774310 chr15:58985164 T/G cg05156742 chr15:59063176 FAM63B 0.47 6.63 0.34 1.36e-10 Schizophrenia; LUSC cis rs1014246 0.848 rs11197799 chr10:118457650 C/T cg14919929 chr10:118506882 NA 0.46 7.25 0.37 2.91e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs10754283 0.901 rs4520403 chr1:90112840 T/G cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg11764359 chr7:65958608 NA -0.79 -12.98 -0.58 1.74e-31 Aortic root size; LUSC cis rs950881 0.932 rs72823621 chr2:102925435 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.29 0.33 1.02e-9 Allergy; LUSC trans rs9929218 1.000 rs8056538 chr16:68802282 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.86 -0.54 2.63e-27 Colorectal cancer; LUSC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4704187 0.663 rs1477935 chr5:74448494 C/T cg03227963 chr5:74354835 NA 0.32 6.91 0.35 2.44e-11 Response to amphetamines; LUSC cis rs2290159 1.000 rs2290159 chr3:12628920 G/C cg23032965 chr3:12705835 RAF1 0.6 7.57 0.38 3.69e-13 Cholesterol, total; LUSC cis rs9911578 0.835 rs10853006 chr17:56489076 G/A cg12560992 chr17:57184187 TRIM37 -0.71 -12.13 -0.55 2.62e-28 Intelligence (multi-trait analysis); LUSC trans rs561341 1.000 rs8077092 chr17:30281992 T/C cg27661571 chr11:113659931 NA -0.57 -7.05 -0.36 1e-11 Hip circumference adjusted for BMI; LUSC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg27588902 chr6:42928151 GNMT 0.26 5.76 0.3 1.91e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs72772090 0.539 rs11739020 chr5:96113838 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.72 7.88 0.4 4.81e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg13615516 chr5:77269221 NA 0.39 6.49 0.33 3.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1005277 0.691 rs2474558 chr10:38486141 A/C cg13531842 chr10:38383804 ZNF37A 0.44 6.2 0.32 1.69e-9 Extrinsic epigenetic age acceleration; LUSC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg13647721 chr17:30228624 UTP6 0.6 6.24 0.32 1.31e-9 Hip circumference adjusted for BMI; LUSC cis rs11190604 1.000 rs3750630 chr10:102275780 A/G cg16342193 chr10:102329863 NA -0.34 -6.28 -0.32 1.08e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg13628971 chr7:2884303 GNA12 -0.41 -6.07 -0.32 3.47e-9 Height; LUSC cis rs1950626 0.623 rs4402490 chr14:101445453 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.4 -7.49 -0.38 6.01e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs7072216 0.763 rs8181292 chr10:100175477 A/G cg26618903 chr10:100175079 PYROXD2 -0.46 -8.68 -0.43 1.8e-16 Metabolite levels; LUSC cis rs11702148 0.552 rs2154583 chr21:34888940 T/G cg14850771 chr21:34775459 IFNGR2 0.4 5.88 0.31 9.95e-9 Mean corpuscular hemoglobin; LUSC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg17330251 chr7:94953956 PON1 -0.41 -6.74 -0.35 6.82e-11 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs12956009 0.559 rs1893787 chr18:44856030 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.24 0.32 1.35e-9 Educational attainment (years of education); LUSC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg06008330 chr7:65541103 ASL -0.39 -6.03 -0.31 4.35e-9 Aortic root size; LUSC cis rs7267979 1.000 rs2424713 chr20:25418482 C/T cg03522245 chr20:25566470 NINL 0.35 5.78 0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg01020399 chr1:249153122 ZNF692 0.42 6.06 0.31 3.77e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs9427116 0.531 rs35504625 chr1:154599778 C/G cg17218026 chr1:154582156 ADAR 0.59 10.45 0.5 2.66e-22 Blood protein levels; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg07677032 chr17:61819896 STRADA 0.54 8.94 0.44 2.69e-17 Prudent dietary pattern; LUSC cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg27129171 chr3:47204927 SETD2 0.69 11.48 0.53 6.36e-26 Colorectal cancer; LUSC cis rs765787 0.530 rs13329228 chr15:45533017 C/T cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.32e-11 Uric acid levels; LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg24813613 chr7:1882135 MAD1L1 -0.43 -7.16 -0.36 5.04e-12 Bipolar disorder and schizophrenia; LUSC cis rs983392 0.709 rs11230194 chr11:59980315 C/G cg02771260 chr11:59836817 MS4A3 -0.36 -5.92 -0.31 8.12e-9 Alzheimer's disease (late onset); LUSC cis rs13385 0.769 rs56997077 chr5:139558412 C/T cg26211634 chr5:139558579 C5orf32 0.45 6.3 0.33 9.46e-10 Atrial fibrillation; LUSC cis rs9814567 0.964 rs9820425 chr3:134223018 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.69 -0.6 3.65e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg26579491 chr7:65878976 NA 0.4 5.68 0.3 2.91e-8 Aortic root size; LUSC cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg06064525 chr11:970664 AP2A2 -0.48 -10.56 -0.5 1.08e-22 Alzheimer's disease (late onset); LUSC cis rs950776 0.518 rs11636131 chr15:78821606 C/T cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs6967385 0.560 rs12539290 chr7:12344101 T/G cg06484146 chr7:12443880 VWDE 0.45 6.81 0.35 4.46e-11 Response to taxane treatment (placlitaxel); LUSC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg01283332 chr5:1856932 NA -0.34 -6.35 -0.33 7.22e-10 Cardiovascular disease risk factors; LUSC cis rs4654899 0.680 rs2305463 chr1:21180181 C/T cg01072550 chr1:21505969 NA 0.48 7.2 0.37 3.92e-12 Superior frontal gyrus grey matter volume; LUSC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg18357645 chr12:58087776 OS9 -0.43 -5.96 -0.31 6.38e-9 Multiple sclerosis; LUSC cis rs11190604 1.000 rs2489049 chr10:102350732 G/A cg07080220 chr10:102295463 HIF1AN 0.66 9.05 0.44 1.25e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4595586 0.545 rs7308161 chr12:39363459 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.26 0.37 2.66e-12 Morning vs. evening chronotype; LUSC cis rs7107174 1.000 rs10899491 chr11:78106305 T/C cg02023728 chr11:77925099 USP35 0.46 6.7 0.34 8.82e-11 Testicular germ cell tumor; LUSC cis rs7180079 1.000 rs8029682 chr15:64628534 C/T cg08069370 chr15:64387884 SNX1 0.57 6.28 0.32 1.05e-9 Monocyte count; LUSC cis rs7208859 0.623 rs9890862 chr17:29125450 C/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs9784649 0.771 rs72755810 chr5:25039139 A/C cg08600765 chr20:34638493 LOC647979 -0.56 -7.31 -0.37 1.98e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9875589 0.509 rs9867041 chr3:14014615 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 6.9 0.35 2.64e-11 Ovarian reserve; LUSC cis rs57994353 0.578 rs10448340 chr9:139320069 A/C cg14169450 chr9:139327907 INPP5E 0.37 6.07 0.32 3.43e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; LUSC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg22920501 chr2:26401640 FAM59B -0.75 -10.64 -0.5 5.79e-23 Gut microbiome composition (summer); LUSC cis rs11650494 0.803 rs117801358 chr17:47447950 C/A cg08112188 chr17:47440006 ZNF652 1.39 11.35 0.53 1.76e-25 Prostate cancer; LUSC trans rs4942242 0.512 rs9533551 chr13:44187120 G/C cg19169023 chr15:41853346 TYRO3 -0.67 -10.13 -0.48 3.24e-21 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6429082 0.715 rs2131924 chr1:235580928 G/A cg26050004 chr1:235667680 B3GALNT2 -0.53 -7.4 -0.38 1.14e-12 Adiposity; LUSC cis rs10782582 0.593 rs1412717 chr1:76125471 C/T cg22875332 chr1:76189707 ACADM -0.42 -6.24 -0.32 1.35e-9 Daytime sleep phenotypes; LUSC cis rs11662586 0.517 rs7228070 chr18:77698967 C/T cg20368463 chr18:77673604 PQLC1 0.8 14.04 0.61 1.59e-35 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg13206674 chr6:150067644 NUP43 0.57 9.08 0.44 9.89e-18 Lung cancer; LUSC cis rs8044995 0.563 rs3743743 chr16:68397775 C/T cg05110241 chr16:68378359 PRMT7 -0.85 -9.27 -0.45 2.36e-18 Schizophrenia; LUSC cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.95 0.4 2.89e-14 Colorectal cancer; LUSC cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7397814 0.558 rs4764447 chr12:9579109 C/T cg26689682 chr12:9723402 NA -0.42 -5.83 -0.3 1.29e-8 IgG glycosylation; LUSC cis rs66887589 0.934 rs12648182 chr4:120503891 T/A cg09307838 chr4:120376055 NA -0.48 -7.29 -0.37 2.29e-12 Diastolic blood pressure; LUSC cis rs7605827 0.930 rs2160693 chr2:15654669 A/T cg19274914 chr2:15703543 NA 0.46 8.81 0.43 6.91e-17 Educational attainment (years of education); LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg08888203 chr3:10149979 C3orf24 0.68 9.35 0.46 1.27e-18 Alzheimer's disease; LUSC cis rs9611519 1.000 rs5758268 chr22:41622419 A/T cg13813247 chr22:41461852 NA -0.35 -6.39 -0.33 5.47e-10 Neuroticism; LUSC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg05084668 chr3:125655381 ALG1L -0.51 -7.13 -0.36 6.09e-12 Blood pressure (smoking interaction); LUSC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg05340658 chr4:99064831 C4orf37 0.68 11.73 0.54 7.63e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs751728 1.000 rs2395449 chr6:33728755 T/A cg25922239 chr6:33757077 LEMD2 0.52 7.65 0.39 2.11e-13 Crohn's disease; LUSC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg10645314 chr2:3704589 ALLC -0.73 -11.69 -0.54 1.05e-26 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7568458 0.709 rs11895401 chr2:85753847 C/T cg02493740 chr2:85810744 VAMP5 -0.49 -8.62 -0.43 2.68e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.95 -0.31 6.6e-9 Tonsillectomy; LUSC cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -8.56 -0.42 4.25e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12190007 0.514 rs2984462 chr6:169843903 A/T cg15038512 chr6:170123185 PHF10 -0.39 -6.38 -0.33 5.79e-10 Obesity-related traits; LUSC cis rs4474465 0.920 rs7947824 chr11:78223731 C/G cg27205649 chr11:78285834 NARS2 0.53 6.08 0.32 3.31e-9 Alzheimer's disease (survival time); LUSC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC trans rs6951245 1.000 rs113575110 chr7:1084394 G/A cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs440932 1.000 rs440932 chr8:9026929 T/C cg06636001 chr8:8085503 FLJ10661 0.42 5.96 0.31 6.38e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs7267979 1.000 rs6515651 chr20:25414539 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.75 -0.73 4.73e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9611565 0.506 rs2024567 chr22:41699206 G/C cg03806693 chr22:41940476 POLR3H -0.63 -9.21 -0.45 3.59e-18 Vitiligo; LUSC cis rs8048589 0.604 rs12929519 chr16:12207439 A/G cg02910054 chr16:12241554 SNX29 -0.47 -6.45 -0.33 3.89e-10 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg26384229 chr12:38710491 ALG10B 0.84 14.45 0.62 4.06e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs7829975 0.560 rs4841013 chr8:8552013 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.5 -0.34 2.87e-10 Mood instability; LUSC trans rs911555 0.723 rs4906324 chr14:103923099 A/G cg17675199 chr6:35436792 RPL10A -0.42 -6.16 -0.32 2.14e-9 Intelligence (multi-trait analysis); LUSC cis rs738322 0.742 rs4821767 chr22:38614129 G/T cg25457927 chr22:38595422 NA 0.41 8.57 0.42 3.85e-16 Cutaneous nevi; LUSC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg24562669 chr7:97807699 LMTK2 0.36 6.3 0.33 9.49e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.47e-24 Aortic root size; LUSC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs427394 0.582 rs274662 chr5:6704860 G/A cg10857441 chr5:6722123 POLS -0.42 -7.81 -0.39 7.23e-14 Menopause (age at onset); LUSC cis rs11190604 1.000 rs11190578 chr10:102238953 C/T cg07080220 chr10:102295463 HIF1AN 0.63 8.34 0.42 1.94e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1997103 0.954 rs9649780 chr7:55411741 A/C cg17469321 chr7:55412551 NA 0.64 10.19 0.49 2.02e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg26897989 chr16:1907736 C16orf73 -0.42 -6.63 -0.34 1.37e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs11690935 0.531 rs62183800 chr2:172867273 C/T cg13550731 chr2:172543902 DYNC1I2 0.53 7.96 0.4 2.7e-14 Schizophrenia; LUSC cis rs9902453 0.757 rs12453308 chr17:28441604 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.14 0.41 7.79e-15 Coffee consumption (cups per day); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg25953220 chr6:159240552 EZR 0.4 6.11 0.32 2.81e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs2274273 0.744 rs8011808 chr14:55823344 A/T cg04306507 chr14:55594613 LGALS3 0.56 13.05 0.58 9.37e-32 Protein biomarker; LUSC cis rs9650657 0.538 rs6984496 chr8:10796093 G/T cg21775007 chr8:11205619 TDH -0.49 -7.14 -0.36 5.77e-12 Neuroticism; LUSC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.51 6.33 0.33 7.69e-10 Schizophrenia; LUSC trans rs28647808 0.786 rs28590601 chr9:136256224 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.32 0.67 1.92e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34421088 0.548 rs2618443 chr8:11384556 A/G cg21775007 chr8:11205619 TDH -0.46 -6.74 -0.35 6.85e-11 Neuroticism; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg08677398 chr8:58056175 NA 0.58 7.01 0.36 1.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769707 0.872 rs5770604 chr22:50030672 G/A cg08680598 chr22:49984980 NA -0.32 -6.07 -0.32 3.44e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2486288 0.656 rs8037583 chr15:45546378 A/G cg26924012 chr15:45694286 SPATA5L1 -0.75 -11.08 -0.52 1.72e-24 Glomerular filtration rate; LUSC cis rs1160297 0.634 rs10179810 chr2:53096145 T/A cg07782112 chr2:53107842 NA 0.43 6.99 0.36 1.51e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs7772486 0.875 rs1330939 chr6:146308518 T/A cg13319975 chr6:146136371 FBXO30 -0.47 -6.9 -0.35 2.69e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7107174 0.892 rs10431155 chr11:78121978 T/C cg02023728 chr11:77925099 USP35 0.46 6.83 0.35 4.05e-11 Testicular germ cell tumor; LUSC cis rs12701220 0.803 rs12701432 chr7:1052453 C/T cg00990874 chr7:1149470 C7orf50 -0.51 -6.45 -0.33 3.98e-10 Bronchopulmonary dysplasia; LUSC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg09365446 chr1:150670422 GOLPH3L -0.49 -7.67 -0.39 1.92e-13 Tonsillectomy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06911843 chr21:38639729 DSCR3 0.51 7.16 0.36 5.31e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg22834771 chr12:69754056 YEATS4 0.51 7.71 0.39 1.45e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs5167 0.566 rs35080293 chr19:45496624 T/G cg13119609 chr19:45449297 APOC2 0.34 5.67 0.3 3.01e-8 Blood protein levels; LUSC cis rs17125944 0.615 rs2357944 chr14:53305573 T/G cg00686598 chr14:53173677 PSMC6 -0.66 -5.73 -0.3 2.23e-8 Alzheimer's disease (late onset); LUSC cis rs7666738 0.515 rs28615369 chr4:98896858 C/T cg17366294 chr4:99064904 C4orf37 0.52 8.32 0.41 2.26e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9300255 0.506 rs61388686 chr12:123810873 G/A cg00376283 chr12:123451042 ABCB9 0.71 10.93 0.51 5.64e-24 Neutrophil percentage of white cells; LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg24642844 chr7:1081250 C7orf50 -0.81 -11.13 -0.52 1.06e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 7.95e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs694739 0.628 rs10897487 chr11:64140704 C/T cg26898376 chr11:64110657 CCDC88B 0.31 5.78 0.3 1.69e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs17270561 0.609 rs1892255 chr6:25750354 G/A cg17691542 chr6:26056736 HIST1H1C 0.58 8.11 0.41 9.78e-15 Iron status biomarkers; LUSC cis rs2046867 0.818 rs62249861 chr3:72867779 A/G cg25664220 chr3:72788482 NA -0.71 -11.91 -0.55 1.71e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC trans rs2243480 1.000 rs35542501 chr7:65431215 T/C cg10756647 chr7:56101905 PSPH 0.85 8.34 0.42 2.04e-15 Diabetic kidney disease; LUSC cis rs3743266 0.613 rs10851681 chr15:60732138 C/T cg21667061 chr15:60772094 NARG2 0.36 6.15 0.32 2.23e-9 Menarche (age at onset); LUSC cis rs4834770 1.000 rs4834770 chr4:120241849 A/G cg24375607 chr4:120327624 NA 0.4 5.75 0.3 1.97e-8 Blood protein levels; LUSC cis rs73206853 0.764 rs73194012 chr12:111100627 T/C cg12870014 chr12:110450643 ANKRD13A 0.7 7.55 0.38 4.26e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg02931644 chr1:25747376 RHCE 0.39 7.1 0.36 7.58e-12 Erythrocyte sedimentation rate; LUSC cis rs7177699 0.557 rs8035093 chr15:79120670 T/C cg00540400 chr15:79124168 NA 0.45 7.94 0.4 3.17e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs73001065 0.591 rs56273306 chr19:19621004 T/C cg03709012 chr19:19516395 GATAD2A 0.97 8.79 0.43 8.08e-17 LDL cholesterol; LUSC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg17633681 chr16:88106987 BANP 0.5 9.24 0.45 2.89e-18 Menopause (age at onset); LUSC cis rs7917772 0.560 rs11595170 chr10:104339851 T/C cg05855489 chr10:104503620 C10orf26 0.49 7.57 0.38 3.79e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs1997103 1.000 rs6977292 chr7:55396335 T/C cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg00033643 chr7:134001901 SLC35B4 0.43 6.39 0.33 5.42e-10 Mean platelet volume; LUSC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg13010199 chr12:38710504 ALG10B 0.66 9.93 0.48 1.57e-20 Bladder cancer; LUSC cis rs1035144 0.506 rs7150858 chr14:81280425 T/C cg06600135 chr14:81408086 NA -0.53 -8.01 -0.4 1.99e-14 Male sexual orientation; LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs400736 0.526 rs10864329 chr1:8164460 G/A cg25007680 chr1:8021821 PARK7 -0.41 -6.15 -0.32 2.27e-9 Response to antidepressants and depression; LUSC trans rs1997103 0.798 rs12154964 chr7:55414041 G/A cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.73e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg23205692 chr1:25664452 TMEM50A 0.42 6.22 0.32 1.51e-9 Erythrocyte sedimentation rate; LUSC trans rs17597773 0.638 rs7544735 chr1:220998913 A/G cg25786136 chr2:222575520 NA -0.39 -5.99 -0.31 5.28e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1692580 0.840 rs262679 chr1:2169792 C/T cg03732007 chr1:2071316 PRKCZ 0.37 5.83 0.3 1.27e-8 Coronary artery disease; LUSC cis rs6541297 0.645 rs4846918 chr1:230300586 A/G cg20703242 chr1:230279135 GALNT2 -0.48 -5.81 -0.3 1.48e-8 Coronary artery disease; LUSC trans rs330071 0.686 rs4841139 chr8:9249210 C/T cg14343924 chr8:8086146 FLJ10661 0.42 6.04 0.31 4.04e-9 Acne (severe); LUSC cis rs9494145 0.531 rs9399136 chr6:135402339 T/C cg24558204 chr6:135376177 HBS1L 0.48 6.03 0.31 4.44e-9 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg03526776 chr6:41159608 TREML2 0.33 6.39 0.33 5.57e-10 Alzheimer's disease (late onset); LUSC cis rs4566357 0.615 rs12328878 chr2:227918962 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.23 -0.41 4.35e-15 Coronary artery disease; LUSC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg21918786 chr6:109611834 NA -0.36 -6.02 -0.31 4.66e-9 Reticulocyte fraction of red cells; LUSC cis rs4356932 1.000 rs4583787 chr4:76955069 G/A cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs7149337 0.752 rs8021773 chr14:51691528 C/T cg23942311 chr14:51606299 NA 0.52 11.75 0.54 6.28e-27 Cancer; LUSC cis rs9837602 0.938 rs1021341 chr3:99786289 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.55 0.34 2.17e-10 Breast cancer; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.41 0.46 8.16e-19 Prudent dietary pattern; LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.63 0.47 1.59e-19 Bipolar disorder; LUSC cis rs73206853 0.764 rs6606685 chr12:110881986 C/G cg12870014 chr12:110450643 ANKRD13A 0.5 5.9 0.31 9.03e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6964587 1.000 rs7800582 chr7:91701346 G/A cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs4805834 0.668 rs17272183 chr19:33321213 A/G cg00891608 chr19:33463040 C19orf40;CCDC123 -0.57 -5.64 -0.3 3.54e-8 Creatinine levels; LUSC cis rs9648716 0.515 rs38719 chr7:140693894 G/T cg23214464 chr7:140373596 ADCK2 0.75 6.21 0.32 1.54e-9 Type 2 diabetes; LUSC trans rs9929218 0.861 rs4783667 chr16:68752878 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -12.52 -0.57 9.69e-30 Colorectal cancer; LUSC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg25039879 chr17:56429692 SUPT4H1 0.72 9.78 0.47 5.07e-20 Cognitive test performance; LUSC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg02782426 chr3:40428986 ENTPD3 0.41 7.69 0.39 1.65e-13 Renal cell carcinoma; LUSC cis rs11608355 0.515 rs4766606 chr12:109934390 C/G cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg03806693 chr22:41940476 POLR3H -1.02 -13.77 -0.6 1.74e-34 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.61 8.33 0.41 2.15e-15 Chronic sinus infection; LUSC cis rs9815354 0.812 rs56983571 chr3:41994473 T/C cg03022575 chr3:42003672 ULK4 0.85 8.86 0.44 4.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs9467773 0.935 rs1056668 chr6:26510605 C/T cg09904177 chr6:26538194 HMGN4 0.69 11.91 0.55 1.76e-27 Intelligence (multi-trait analysis); LUSC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg18180107 chr4:99064573 C4orf37 0.41 5.7 0.3 2.62e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg04369109 chr6:150039330 LATS1 0.56 8.36 0.42 1.68e-15 Lung cancer; LUSC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.79 -0.35 5.25e-11 Lung cancer; LUSC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11644478 chr21:40555479 PSMG1 0.94 19.11 0.72 1.61e-55 Cognitive function; LUSC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg21770322 chr7:97807741 LMTK2 0.4 7.01 0.36 1.31e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2486288 0.656 rs11629859 chr15:45547121 T/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.73 -0.39 1.31e-13 Glomerular filtration rate; LUSC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg02269571 chr22:50332266 NA -0.57 -8.73 -0.43 1.25e-16 Schizophrenia; LUSC cis rs55665837 0.559 rs11023210 chr11:14422762 A/G cg05501817 chr11:14380813 RRAS2 0.45 7.06 0.36 9.92e-12 Vitamin D levels; LUSC cis rs4356932 0.967 rs4859605 chr4:76965822 C/G cg00809888 chr4:76862425 NAAA 0.34 5.68 0.3 2.94e-8 Blood protein levels; LUSC cis rs12210905 0.800 rs12209651 chr6:26660925 A/C cg11502198 chr6:26597334 ABT1 -0.74 -5.77 -0.3 1.8e-8 Hip circumference adjusted for BMI; LUSC trans rs4650994 0.525 rs2493848 chr1:178547838 T/A cg05059571 chr16:84539110 KIAA1609 0.48 9.2 0.45 4.08e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg24642439 chr20:33292090 TP53INP2 0.72 11.58 0.54 2.64e-26 Coronary artery disease; LUSC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg11102782 chr19:18549136 ISYNA1 -0.35 -6.55 -0.34 2.15e-10 Breast cancer; LUSC cis rs9611519 1.000 rs4820433 chr22:41607065 C/G cg03806693 chr22:41940476 POLR3H -0.49 -6.78 -0.35 5.59e-11 Neuroticism; LUSC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.03e-10 Blood pressure (smoking interaction); LUSC cis rs4319547 0.656 rs7975747 chr12:122816995 C/T cg23029597 chr12:123009494 RSRC2 -0.75 -9.32 -0.45 1.69e-18 Body mass index; LUSC cis rs9527 0.590 rs12415388 chr10:104796345 T/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.52 -0.34 2.53e-10 Arsenic metabolism; LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -6.13 -0.32 2.44e-9 Developmental language disorder (linguistic errors); LUSC cis rs6580649 0.941 rs757556 chr12:48502493 C/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.1 -0.32 2.9e-9 Lung cancer; LUSC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg25456477 chr12:86230367 RASSF9 0.44 7.87 0.4 4.98e-14 Major depressive disorder; LUSC cis rs7267979 1.000 rs398036 chr20:25439850 C/T cg08601574 chr20:25228251 PYGB 0.43 6.51 0.34 2.74e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs5770872 0.511 rs56168974 chr22:50831338 A/G cg09860653 chr1:19970708 NBL1 -0.6 -8.43 -0.42 1.07e-15 Tonsillectomy; LUSC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg00149659 chr3:10157352 C3orf10 0.92 12.89 0.58 3.82e-31 Alzheimer's disease; LUSC trans rs2301573 0.584 rs1136553 chr3:129366963 G/T cg06813419 chr1:211502171 TRAF5 0.44 5.99 0.31 5.41e-9 Hip circumference; LUSC cis rs1577917 0.958 rs6454488 chr6:86450842 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.5 -0.42 6.29e-16 Response to antipsychotic treatment; LUSC trans rs12310956 0.532 rs11052935 chr12:33970946 C/T cg13010199 chr12:38710504 ALG10B 0.52 7.71 0.39 1.46e-13 Morning vs. evening chronotype; LUSC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg17330251 chr7:94953956 PON1 -0.39 -6.47 -0.33 3.59e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg17279839 chr7:150038598 RARRES2 0.44 7.02 0.36 1.24e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs7617480 0.617 rs7610519 chr3:48746427 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.61 9.39 0.46 9.94e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7520050 0.807 rs6656279 chr1:46124088 C/G cg06784218 chr1:46089804 CCDC17 0.29 5.83 0.3 1.31e-8 Red blood cell count;Reticulocyte count; LUSC cis rs1348850 0.958 rs10930799 chr2:178459325 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.8 0.3 1.52e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10779751 0.690 rs743577 chr1:11119135 G/A cg08854313 chr1:11322531 MTOR 0.8 11.81 0.54 3.86e-27 Body mass index; LUSC cis rs2455601 0.638 rs2248245 chr11:8988350 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -6.35 -0.33 7.11e-10 Schizophrenia; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.42 5.82 0.3 1.35e-8 Renal function-related traits (BUN); LUSC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25719439 chr16:89788035 C16orf7;ZNF276 -0.4 -6.14 -0.32 2.32e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9398803 0.830 rs1361109 chr6:126771143 C/T cg19875578 chr6:126661172 C6orf173 0.41 5.93 0.31 7.72e-9 Male-pattern baldness; LUSC cis rs7937890 0.732 rs7946902 chr11:14273308 C/T cg19336497 chr11:14380999 RRAS2 0.4 7.11 0.36 7.1e-12 Mitochondrial DNA levels; LUSC cis rs2970818 0.831 rs2907494 chr12:4642184 G/A cg11146114 chr12:4671731 NA -0.59 -6.33 -0.33 7.79e-10 Phosphorus levels; LUSC cis rs6938 0.597 rs4886641 chr15:75228655 C/A cg14664628 chr15:75095509 CSK -0.54 -7.96 -0.4 2.7e-14 Breast cancer; LUSC cis rs1506636 1.000 rs656425 chr7:123424525 A/C cg03229431 chr7:123269106 ASB15 0.65 10.68 0.5 4.29e-23 Plateletcrit;Platelet count; LUSC cis rs11696845 0.712 rs6130685 chr20:43366730 T/G cg25301532 chr20:43378953 KCNK15 0.35 6.18 0.32 1.89e-9 Obesity-related traits; LUSC cis rs9300255 0.568 rs1627724 chr12:123638580 T/A cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.12 -0.32 2.63e-9 Neutrophil percentage of white cells; LUSC cis rs7100689 0.784 rs7078075 chr10:82162768 A/G cg01528321 chr10:82214614 TSPAN14 1.07 16.7 0.67 6.18e-46 Post bronchodilator FEV1; LUSC cis rs17818399 0.926 rs35682608 chr2:46836542 A/T cg02822958 chr2:46747628 ATP6V1E2 0.39 6.09 0.32 3.1e-9 Height; LUSC trans rs11039798 0.764 rs12277213 chr11:48782176 G/A cg03929089 chr4:120376271 NA 0.71 6.74 0.35 7.11e-11 Axial length; LUSC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg14019146 chr3:50243930 SLC38A3 0.35 7.88 0.4 4.57e-14 Body mass index; LUSC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg26304593 chr6:42947056 PEX6 -0.49 -7.36 -0.37 1.46e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg09455208 chr3:40491958 NA 0.49 8.49 0.42 6.77e-16 Renal cell carcinoma; LUSC cis rs9894429 0.624 rs9910935 chr17:79613949 T/C cg21028142 chr17:79581711 NPLOC4 0.32 7.53 0.38 4.81e-13 Eye color traits; LUSC cis rs3087591 0.592 rs2342054 chr17:29724708 G/A cg24425628 chr17:29625626 OMG;NF1 0.47 6.88 0.35 3.03e-11 Hip circumference; LUSC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg09796270 chr17:17721594 SREBF1 0.43 7.65 0.39 2.17e-13 Total body bone mineral density; LUSC cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.93e-21 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23331932 chr10:99894438 C10orf28 -0.47 -6.92 -0.35 2.25e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg08109568 chr15:31115862 NA -0.54 -7.79 -0.39 8.5e-14 Huntington's disease progression; LUSC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg24209194 chr3:40518798 ZNF619 0.44 5.91 0.31 8.25e-9 Renal cell carcinoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03899609 chr16:29911630 SEZ6L2;ASPHD1 0.77 6.18 0.32 1.91e-9 Cognitive performance; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19794706 chr14:75643232 TMED10 -0.51 -6.18 -0.32 1.85e-9 Bipolar disorder and schizophrenia; LUSC cis rs7824557 0.564 rs55758514 chr8:11230259 A/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.86 -0.31 1.14e-8 Retinal vascular caliber; LUSC cis rs2742417 0.603 rs2742370 chr3:45782098 T/C cg04837898 chr3:45731254 SACM1L -0.46 -7.5 -0.38 5.97e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs72781680 1.000 rs72781679 chr2:24237712 G/A cg08917208 chr2:24149416 ATAD2B 0.99 10.34 0.49 6.45e-22 Lymphocyte counts; LUSC cis rs6541297 1.000 rs6674744 chr1:230279011 C/T cg20703242 chr1:230279135 GALNT2 0.55 8.47 0.42 7.77e-16 Coronary artery disease; LUSC cis rs8025790 0.508 rs28673019 chr15:67809823 T/A cg05925327 chr15:68127851 NA -0.38 -5.86 -0.31 1.09e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg12311346 chr5:56204834 C5orf35 -0.93 -13.49 -0.59 2.03e-33 Initial pursuit acceleration; LUSC trans rs4714291 0.925 rs847750 chr6:40074250 G/A cg02267698 chr19:7991119 CTXN1 0.54 7.63 0.39 2.41e-13 Strep throat; LUSC cis rs7075426 0.512 rs9633738 chr10:88183796 T/A cg07322936 chr10:88137208 NA -0.57 -7.82 -0.39 7.15e-14 Migraine without aura; LUSC cis rs7202877 0.656 rs4888394 chr16:75413709 T/C cg04384234 chr16:75411784 CFDP1 -0.65 -9.05 -0.44 1.18e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6500395 0.962 rs9938126 chr16:48572121 A/T cg04672837 chr16:48644449 N4BP1 0.45 6.52 0.34 2.66e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -8.66 -0.43 2.05e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10751667 0.961 rs10902263 chr11:992691 A/C ch.11.42038R chr11:967971 AP2A2 -0.51 -7.53 -0.38 4.83e-13 Alzheimer's disease (late onset); LUSC cis rs62103177 0.608 rs551643 chr18:77838970 C/G cg20368463 chr18:77673604 PQLC1 -0.62 -6.64 -0.34 1.29e-10 Opioid sensitivity; LUSC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg01973587 chr1:228161476 NA -0.4 -7.24 -0.37 3.09e-12 Diastolic blood pressure; LUSC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg09034736 chr1:150693464 HORMAD1 -0.4 -5.75 -0.3 2.05e-8 Tonsillectomy; LUSC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg07424592 chr7:64974309 NA 0.66 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs4304924 0.500 rs2281856 chr13:79207644 C/T cg01819759 chr13:79234251 RNF219 -0.55 -7.79 -0.39 8.43e-14 Large artery stroke; LUSC cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg08807101 chr21:30365312 RNF160 0.7 12.35 0.56 4.07e-29 Dental caries; LUSC cis rs10489202 1.000 rs34774552 chr1:168032245 G/A cg24449463 chr1:168025552 DCAF6 -0.58 -7.24 -0.37 3.16e-12 Schizophrenia; LUSC cis rs6591182 0.504 rs7116712 chr11:65372518 A/G cg27068330 chr11:65405492 SIPA1 -0.65 -9.42 -0.46 7.55e-19 Non-alcoholic fatty liver disease histology (lobular); LUSC cis rs1055129 0.560 rs2305913 chr17:73922941 T/C cg14829360 chr17:73884958 NA -0.35 -5.75 -0.3 1.96e-8 White matter hyperintensity burden; LUSC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg17366294 chr4:99064904 C4orf37 0.54 9.48 0.46 4.75e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 0.900 rs4279 chr7:91764128 C/A cg22117172 chr7:91764530 CYP51A1 0.33 5.88 0.31 9.86e-9 Breast cancer; LUSC cis rs4819052 0.679 rs2838859 chr21:46684517 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.55 8.24 0.41 4e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg06481639 chr22:41940642 POLR3H -0.53 -6.04 -0.31 4.02e-9 Vitiligo; LUSC cis rs4588572 0.643 rs13155648 chr5:77755343 A/G cg11547950 chr5:77652471 NA -0.55 -7.79 -0.39 8.27e-14 Triglycerides; LUSC cis rs2282300 0.739 rs1222211 chr11:30362239 A/C cg25418670 chr11:30344373 C11orf46 -0.65 -9.28 -0.45 2.19e-18 Morning vs. evening chronotype; LUSC cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6489882 0.867 rs4766675 chr12:113365453 A/T cg20102336 chr12:113376681 OAS3 -0.46 -5.99 -0.31 5.45e-9 Chronic lymphocytic leukemia; LUSC cis rs76878669 0.538 rs2282530 chr11:66177952 C/T cg24851651 chr11:66362959 CCS 0.4 6.14 0.32 2.31e-9 Educational attainment (years of education); LUSC cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -7.71 -0.39 1.43e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9527 0.569 rs10883801 chr10:104677887 A/C cg05855489 chr10:104503620 C10orf26 0.52 8.02 0.4 1.85e-14 Arsenic metabolism; LUSC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.34 0.46 1.4e-18 Bipolar disorder; LUSC cis rs1775715 0.870 rs11008702 chr10:32244818 T/G cg04359828 chr10:32216031 ARHGAP12 0.38 6.34 0.33 7.58e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg03676636 chr4:99064102 C4orf37 0.34 7.23 0.37 3.24e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg25258033 chr6:167368657 RNASET2 -0.49 -8.15 -0.41 7.19e-15 Crohn's disease; LUSC trans rs804280 0.509 rs35626932 chr8:11786932 C/A cg15556689 chr8:8085844 FLJ10661 0.57 8.61 0.43 2.98e-16 Myopia (pathological); LUSC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -7.1 -0.36 7.45e-12 Alzheimer's disease (late onset); LUSC cis rs11122272 0.735 rs2749711 chr1:231537543 G/A cg06096015 chr1:231504339 EGLN1 0.57 10.05 0.48 6.02e-21 Hemoglobin concentration; LUSC cis rs10751667 1.000 rs6597965 chr11:964476 A/G ch.11.42038R chr11:967971 AP2A2 0.55 8.46 0.42 8.36e-16 Alzheimer's disease (late onset); LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg15839431 chr19:19639596 YJEFN3 0.61 6.42 0.33 4.71e-10 Bipolar disorder; LUSC cis rs4809219 1 rs4809219 chr20:62303115 C/A cg16989086 chr20:62203971 PRIC285 -0.53 -7.31 -0.37 1.95e-12 Atopic dermatitis; LUSC cis rs477692 1.000 rs513736 chr10:131406489 C/T cg11019008 chr10:131425282 MGMT 0.43 6.58 0.34 1.85e-10 Response to temozolomide; LUSC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg02187348 chr16:89574699 SPG7 0.57 9.28 0.45 2.25e-18 Multiple myeloma (IgH translocation); LUSC cis rs7614311 0.636 rs56165216 chr3:63916620 C/T cg22134162 chr3:63841271 THOC7 -0.44 -5.71 -0.3 2.44e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11890956 chr21:40555474 PSMG1 -0.9 -16.22 -0.66 4.64e-44 Cognitive function; LUSC cis rs136211 0.599 rs9610497 chr22:36767359 C/T cg10790723 chr22:36903033 FOXRED2 0.41 6.12 0.32 2.63e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs202126107 1 rs202126107 chr17:38006767 GCATATTATA/G cg19468946 chr17:37922297 IKZF3 -0.39 -6.04 -0.31 4.16e-9 Eosinophil percentage of white cells; LUSC cis rs6920965 0.509 rs654213 chr6:126149127 C/T cg05901451 chr6:126070800 HEY2 0.4 5.72 0.3 2.41e-8 High light scatter reticulocyte count; LUSC cis rs17854409 1.000 rs66956644 chr20:61484499 T/C cg05147244 chr20:61493195 TCFL5 0.93 6.86 0.35 3.27e-11 Obesity-related traits; LUSC cis rs11148252 0.508 rs6561671 chr13:53182314 G/A cg02158880 chr13:53174818 NA 0.57 10.02 0.48 7.84e-21 Lewy body disease; LUSC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.57 -0.38 3.6e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg16325326 chr1:53192061 ZYG11B 0.86 15.3 0.64 2.12e-40 Monocyte count; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg10729496 chr3:10149963 C3orf24 0.58 7.69 0.39 1.61e-13 Alzheimer's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20180585 chr22:41777755 TEF 0.79 6.93 0.35 2.24e-11 Cognitive performance; LUSC cis rs2235649 0.833 rs9929262 chr16:1851928 T/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -5.96 -0.31 6.47e-9 Blood metabolite levels; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg24675658 chr1:53192096 ZYG11B -0.62 -10.42 -0.5 3.26e-22 Monocyte count; LUSC cis rs1595825 0.891 rs16823385 chr2:198602101 G/A cg00982548 chr2:198649783 BOLL -0.54 -6.58 -0.34 1.87e-10 Ulcerative colitis; LUSC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs28735056 0.904 rs11520415 chr18:77620620 C/T cg20368463 chr18:77673604 PQLC1 0.5 7.13 0.36 6.28e-12 Schizophrenia; LUSC cis rs113835537 0.627 rs11227534 chr11:66336171 C/A cg24851651 chr11:66362959 CCS 0.57 8.75 0.43 1.05e-16 Airway imaging phenotypes; LUSC cis rs28595532 0.702 rs72670238 chr4:119322751 C/T cg02775129 chr4:119771670 NA -0.7 -5.82 -0.3 1.39e-8 Cannabis dependence symptom count; LUSC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg11812906 chr14:75593930 NEK9 0.64 10.48 0.5 2.02e-22 Height; LUSC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg27165867 chr14:105738592 BRF1 0.52 7.81 0.39 7.32e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs9653442 0.500 rs72819191 chr2:100826572 A/G cg22139774 chr2:100720529 AFF3 0.47 7.46 0.38 7.44e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg16339924 chr4:17578868 LAP3 0.57 8.82 0.43 6.49e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg04865166 chr7:105162814 PUS7 0.52 5.69 0.3 2.78e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2204008 0.776 rs8186824 chr12:38316537 A/C cg26384229 chr12:38710491 ALG10B 0.86 14.59 0.62 1.22e-37 Bladder cancer; LUSC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg05347473 chr6:146136440 FBXO30 0.45 7.57 0.38 3.57e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12815613 1.000 rs55913575 chr12:121405288 G/A cg02403541 chr12:121454288 C12orf43 -0.46 -5.87 -0.31 1.06e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4692589 0.606 rs11943813 chr4:170938243 T/C cg19918862 chr4:170955249 NA 0.38 6.95 0.36 1.9e-11 Anxiety disorder; LUSC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg02951883 chr7:2050386 MAD1L1 -0.45 -7.74 -0.39 1.18e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg00049323 chr5:472564 LOC25845 -0.41 -6.41 -0.33 4.84e-10 Cystic fibrosis severity; LUSC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg27494647 chr7:150038898 RARRES2 0.44 6.82 0.35 4.28e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08109568 chr15:31115862 NA -0.59 -8.15 -0.41 7.48e-15 Huntington's disease progression; LUSC cis rs61931739 0.569 rs1872746 chr12:33985843 T/C cg06521331 chr12:34319734 NA -0.38 -6.37 -0.33 6.31e-10 Morning vs. evening chronotype; LUSC cis rs7215564 0.908 rs2316062 chr17:78663558 C/T cg23238734 chr17:78661607 RPTOR 0.47 6.1 0.32 2.98e-9 Myopia (pathological); LUSC cis rs12220238 0.915 rs10824074 chr10:75876457 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 7.71 0.39 1.41e-13 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs1728785 0.681 rs4783647 chr16:68558048 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.55 -6.7 -0.34 8.94e-11 Ulcerative colitis; LUSC trans rs13011075 0.919 rs2241947 chr2:68615395 C/T cg23843053 chr4:110736631 GAR1 0.45 5.97 0.31 6.19e-9 Mean corpuscular volume; LUSC trans rs9393777 0.844 rs72839477 chr6:27327000 C/T cg01620082 chr3:125678407 NA -0.79 -6.87 -0.35 3.14e-11 Intelligence (multi-trait analysis); LUSC cis rs9649465 0.561 rs600081 chr7:123414591 A/T cg03229431 chr7:123269106 ASB15 0.48 7.76 0.39 1.03e-13 Migraine; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18777999 chr3:115377360 GAP43 -0.42 -5.94 -0.31 7e-9 Hepatitis; LUSC cis rs1215050 0.791 rs1727278 chr4:98853576 A/G cg05340658 chr4:99064831 C4orf37 -0.44 -6.95 -0.36 1.94e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.13 -0.36 6.26e-12 Alzheimer's disease (late onset); LUSC cis rs7296418 0.663 rs11057276 chr12:123820397 C/T cg05973401 chr12:123451056 ABCB9 -0.54 -7.94 -0.4 3.04e-14 Platelet count; LUSC trans rs9944715 0.954 rs7231430 chr18:43823472 C/T cg01718231 chr17:29326311 RNF135 0.49 7.12 0.36 6.66e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs1448094 0.717 rs7298614 chr12:86296513 C/T cg00310523 chr12:86230176 RASSF9 0.45 8.3 0.41 2.62e-15 Major depressive disorder; LUSC cis rs11608355 1.000 rs10774690 chr12:109859682 G/A cg19025524 chr12:109796872 NA -0.39 -6.0 -0.31 5.26e-9 Neuroticism; LUSC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.65 0.34 1.18e-10 Lung cancer; LUSC cis rs7568458 0.811 rs1446668 chr2:85764960 G/T cg17127132 chr2:85788382 GGCX 0.45 6.96 0.36 1.82e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg12463550 chr7:65579703 CRCP 0.51 7.52 0.38 5.19e-13 Aortic root size; LUSC cis rs425277 0.958 rs7546523 chr1:2043792 G/A cg24578937 chr1:2090814 PRKCZ 0.58 12.99 0.58 1.62e-31 Height; LUSC cis rs7095944 0.614 rs7898003 chr10:126451385 G/A cg08799069 chr10:126477246 METTL10 -0.42 -6.56 -0.34 2.04e-10 Asthma; LUSC cis rs17102423 0.594 rs1124751 chr14:65567601 C/A cg11161011 chr14:65562177 MAX -0.71 -10.78 -0.51 1.95e-23 Obesity-related traits; LUSC cis rs9560113 1.000 rs4771757 chr13:112176379 G/T cg14154082 chr13:112174009 NA 0.38 7.96 0.4 2.63e-14 Menarche (age at onset); LUSC cis rs7577696 0.785 rs2886393 chr2:32371562 G/C cg02381751 chr2:32503542 YIPF4 -0.44 -6.2 -0.32 1.63e-9 Inflammatory biomarkers; LUSC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Melanoma; LUSC cis rs4689388 0.610 rs4328980 chr4:6281756 A/G cg14416269 chr4:6271139 WFS1 0.45 8.36 0.42 1.78e-15 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg06108461 chr20:60628389 TAF4 -0.97 -16.7 -0.67 5.98e-46 Body mass index; LUSC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg10207240 chr12:122356781 WDR66 0.48 6.8 0.35 4.92e-11 Mean corpuscular volume; LUSC cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg24642439 chr20:33292090 TP53INP2 0.71 11.57 0.54 2.81e-26 Coronary artery disease; LUSC cis rs11098499 0.863 rs3775854 chr4:120471971 C/T cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC trans rs62238980 0.614 rs116862462 chr22:32470463 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs9303401 0.625 rs66508449 chr17:56691034 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.49 0.59 2.02e-33 Cognitive test performance; LUSC cis rs4974559 0.947 rs28418481 chr4:1330975 C/G cg02980000 chr4:1222292 CTBP1 0.66 7.79 0.39 8.78e-14 Systolic blood pressure; LUSC cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg16339924 chr4:17578868 LAP3 0.62 9.39 0.46 9.43e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs208515 0.525 rs10455593 chr6:66691341 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.27 0.62 2.12e-36 Exhaled nitric oxide levels; LUSC trans rs11165623 0.564 rs6593612 chr1:97002041 C/A cg10631902 chr5:14652156 NA -0.42 -6.21 -0.32 1.55e-9 Hip circumference;Waist circumference; LUSC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg01097406 chr16:89675127 NA 0.46 9.48 0.46 4.85e-19 Vitiligo; LUSC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.59 -5.76 -0.3 1.91e-8 Cerebrospinal P-tau181p levels; LUSC trans rs72674100 1.000 rs10016960 chr4:97989075 T/A cg16405019 chr1:18959625 PAX7 -0.61 -6.44 -0.33 4.04e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg15083037 chr5:83017644 HAPLN1 0.57 7.68 0.39 1.74e-13 Prostate cancer; LUSC cis rs2806561 0.765 rs2806556 chr1:23502850 G/A cg19743168 chr1:23544995 NA 0.43 8.19 0.41 5.53e-15 Height; LUSC cis rs61931739 0.513 rs4931760 chr12:33898361 T/C cg06521331 chr12:34319734 NA -0.36 -5.98 -0.31 5.61e-9 Morning vs. evening chronotype; LUSC cis rs6964587 0.839 rs6949700 chr7:91467435 A/G cg22709100 chr7:91322751 NA 0.43 6.48 0.33 3.37e-10 Breast cancer; LUSC trans rs8002861 0.664 rs2325089 chr13:44450222 C/G cg12856521 chr11:46389249 DGKZ -0.4 -6.09 -0.32 3.18e-9 Leprosy; LUSC cis rs9902453 0.817 rs3115089 chr17:28031881 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.24 0.45 2.94e-18 Coffee consumption (cups per day); LUSC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC trans rs7937682 0.855 rs7934922 chr11:111500026 T/C cg18187862 chr3:45730750 SACM1L 0.55 7.01 0.36 1.36e-11 Primary sclerosing cholangitis; LUSC cis rs9430161 0.579 rs7542164 chr1:11040223 G/A cg27631724 chr1:11040367 C1orf127 0.56 10.92 0.51 6.1e-24 Ewing sarcoma; LUSC cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg08999081 chr20:33150536 PIGU 0.37 6.84 0.35 3.89e-11 Height; LUSC cis rs7264396 0.790 rs6060582 chr20:34313297 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.64 9.6 0.46 2.01e-19 Total cholesterol levels; LUSC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC cis rs6690583 0.623 rs6679539 chr1:85479457 G/T cg22153463 chr1:85462885 MCOLN2 -0.58 -5.76 -0.3 1.88e-8 Serum sulfate level; LUSC cis rs1506636 1.000 rs2896332 chr7:123297223 A/T cg03229431 chr7:123269106 ASB15 -0.65 -10.62 -0.5 6.66e-23 Plateletcrit;Platelet count; LUSC cis rs9322193 0.567 rs7747457 chr6:150213502 T/A cg13206674 chr6:150067644 NUP43 0.43 6.46 0.33 3.62e-10 Lung cancer; LUSC cis rs1538970 1.000 rs4520450 chr1:45834773 A/G cg05343316 chr1:45956843 TESK2 0.61 8.51 0.42 5.84e-16 Platelet count; LUSC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg25282410 chr6:160211355 TCP1;MRPL18 1.11 17.08 0.68 1.84e-47 Age-related macular degeneration (geographic atrophy); LUSC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg04398451 chr17:18023971 MYO15A 0.55 8.96 0.44 2.36e-17 Total body bone mineral density; LUSC cis rs9549367 0.774 rs9549364 chr13:113903745 T/C cg00898013 chr13:113819073 PROZ -0.57 -8.06 -0.4 1.38e-14 Platelet distribution width; LUSC trans rs61931739 0.853 rs11053002 chr12:34083499 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.81 -0.35 4.66e-11 Morning vs. evening chronotype; LUSC cis rs807669 0.903 rs2854643 chr22:19189706 T/C cg02655711 chr22:19163373 SLC25A1 0.91 17.91 0.7 9.05e-51 Metabolite levels; LUSC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.98 -0.31 5.63e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.83e-11 Intelligence (multi-trait analysis); LUSC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg12751644 chr20:60527061 NA 0.38 6.59 0.34 1.68e-10 Obesity-related traits; LUSC cis rs1801251 1.000 rs13003675 chr2:233584109 C/T cg08000102 chr2:233561755 GIGYF2 0.69 11.44 0.53 8.24e-26 Coronary artery disease; LUSC cis rs9788682 1.000 rs9788682 chr15:78802586 A/G cg24631222 chr15:78858424 CHRNA5 -0.82 -10.78 -0.51 1.93e-23 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2273669 0.667 rs4509156 chr6:109308952 A/C cg05315195 chr6:109294784 ARMC2 0.52 5.88 0.31 1.02e-8 Prostate cancer; LUSC cis rs7712401 0.562 rs377316 chr5:122259875 G/C cg19077854 chr5:122220652 SNX24 0.42 9.27 0.45 2.4e-18 Mean platelet volume; LUSC cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg17063962 chr7:91808500 NA -0.56 -8.65 -0.43 2.21e-16 Breast cancer; LUSC trans rs11039798 1.000 rs115429994 chr11:48761183 C/G cg03929089 chr4:120376271 NA 0.74 6.91 0.35 2.4e-11 Axial length; LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -7.05 -0.36 1.05e-11 Developmental language disorder (linguistic errors); LUSC cis rs1577917 1.000 rs12207610 chr6:86688016 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.41 -0.33 5.09e-10 Response to antipsychotic treatment; LUSC cis rs2227930 0.506 rs9859834 chr3:142106351 A/T cg16271453 chr3:142027066 XRN1 -0.54 -9.85 -0.47 2.8e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs1609391 0.543 rs6800690 chr3:136623026 G/A cg15507776 chr3:136538369 TMEM22 0.5 8.25 0.41 3.79e-15 Neuroticism; LUSC cis rs11971779 0.616 rs6944244 chr7:139051186 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs3850699 0.651 rs35485301 chr10:104370827 C/T cg04362960 chr10:104952993 NT5C2 0.53 6.7 0.34 8.78e-11 Prostate cancer; LUSC cis rs10266483 0.654 rs6962076 chr7:64019592 C/T cg24201672 chr7:64023550 ZNF680 0.52 6.94 0.35 2.1e-11 Response to statin therapy; LUSC cis rs7572644 0.639 rs3792253 chr2:28002002 T/C cg27432699 chr2:27873401 GPN1 0.55 7.06 0.36 9.59e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs769267 0.566 rs7249692 chr19:19670688 T/C cg03709012 chr19:19516395 GATAD2A -0.51 -7.36 -0.37 1.43e-12 Tonsillectomy; LUSC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg21951975 chr1:209979733 IRF6 -0.52 -8.95 -0.44 2.6e-17 Monobrow; LUSC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg17279839 chr7:150038598 RARRES2 0.43 6.6 0.34 1.61e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs868036 0.681 rs28376010 chr15:68063739 G/T cg08079166 chr15:68083412 MAP2K5 0.39 6.71 0.34 8.56e-11 Restless legs syndrome; LUSC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.27 -0.49 1.06e-21 Gut microbiome composition (summer); LUSC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg23985595 chr17:80112537 CCDC57 0.34 6.49 0.33 3.03e-10 Life satisfaction; LUSC cis rs7074356 0.522 rs1591958 chr10:82062661 G/A cg27171509 chr10:82033454 MAT1A -0.3 -6.05 -0.31 3.85e-9 Borderline personality disorder; LUSC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg05754148 chr16:3507555 NAT15 -0.84 -9.07 -0.44 1.03e-17 Tuberculosis; LUSC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg04850211 chr1:228464232 OBSCN 0.32 5.68 0.3 2.92e-8 Diastolic blood pressure; LUSC cis rs12493885 0.628 rs61790906 chr3:153653953 T/G cg17054900 chr3:154042577 DHX36 -0.54 -5.66 -0.3 3.23e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs16937 0.557 rs11240386 chr1:205175401 G/T cg00857998 chr1:205179979 DSTYK 0.46 6.38 0.33 5.75e-10 Schizophrenia; LUSC trans rs61931739 0.500 rs6488221 chr12:34525671 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs5009270 0.553 rs6947690 chr7:112233386 C/G cg23628563 chr7:112262597 NA 0.43 5.87 0.31 1.03e-8 Osteoarthritis (hip); LUSC cis rs11190604 0.943 rs113791644 chr10:102324330 T/G cg07080220 chr10:102295463 HIF1AN 0.68 8.57 0.42 3.86e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6570726 0.902 rs4895678 chr6:145935510 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.5 0.33 2.97e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg11366901 chr6:160182831 ACAT2 0.94 12.73 0.57 1.58e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs11098499 0.821 rs28665282 chr4:120384186 C/T cg24375607 chr4:120327624 NA 0.79 11.69 0.54 1.03e-26 Corneal astigmatism; LUSC cis rs709400 0.628 rs7154246 chr14:103876794 G/A cg12935359 chr14:103987150 CKB 0.54 8.37 0.42 1.58e-15 Body mass index; LUSC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg14552801 chr7:65878734 NA 0.38 5.91 0.31 8.41e-9 Aortic root size; LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.29 0.45 1.97e-18 Bipolar disorder; LUSC trans rs2243480 1.000 rs427044 chr7:65508545 G/A cg10756647 chr7:56101905 PSPH 0.87 8.51 0.42 6.1e-16 Diabetic kidney disease; LUSC cis rs8017423 0.967 rs11626011 chr14:90693572 A/G cg04374321 chr14:90722782 PSMC1 0.68 10.47 0.5 2.33e-22 Mortality in heart failure; LUSC cis rs9303401 0.661 rs9902820 chr17:56637545 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.49 7.8 0.39 7.99e-14 Cognitive test performance; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11963883 chr10:70715832 DDX21 0.46 6.06 0.31 3.68e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg12432903 chr7:1882776 MAD1L1 -0.51 -8.62 -0.43 2.75e-16 Bipolar disorder and schizophrenia; LUSC cis rs4704187 0.687 rs10036527 chr5:74481837 T/C cg03227963 chr5:74354835 NA 0.3 6.54 0.34 2.32e-10 Response to amphetamines; LUSC cis rs6541297 1.000 rs6682741 chr1:230279090 T/C cg05784532 chr1:230284198 GALNT2 0.49 7.41 0.38 1.06e-12 Coronary artery disease; LUSC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -8.16 -0.41 6.95e-15 Personality dimensions; LUSC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.65 14.38 0.62 7.99e-37 Hemoglobin concentration; LUSC cis rs4595586 0.546 rs11609849 chr12:39258090 C/G cg13010199 chr12:38710504 ALG10B 0.63 9.11 0.45 7.63e-18 Morning vs. evening chronotype; LUSC cis rs7246657 0.943 rs7255996 chr19:37971699 G/A cg23950597 chr19:37808831 NA -0.62 -7.43 -0.38 9.32e-13 Coronary artery calcification; LUSC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg08392591 chr16:89556376 ANKRD11 -0.45 -6.98 -0.36 1.56e-11 Multiple myeloma (IgH translocation); LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.84 -0.57 5.96e-31 Platelet count; LUSC cis rs6712932 0.962 rs10496390 chr2:105838791 C/T cg26874229 chr2:105853672 NA -0.32 -6.0 -0.31 5.19e-9 Type 2 diabetes; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.56 9.32 0.45 1.61e-18 Lymphocyte counts; LUSC cis rs654950 0.840 rs647146 chr1:41986286 G/A cg06885757 chr1:42089581 HIVEP3 0.39 7.76 0.39 1.02e-13 Airway imaging phenotypes; LUSC trans rs11723530 0.507 rs4692762 chr4:170814209 G/C cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.28 -0.32 1.03e-9 Myopia (pathological); LUSC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg13206674 chr6:150067644 NUP43 0.59 9.19 0.45 4.2e-18 Lung cancer; LUSC cis rs11098499 0.866 rs13125526 chr4:120288019 G/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC trans rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.72 -12.92 -0.58 3.14e-31 Brugada syndrome; LUSC cis rs6546886 0.957 rs4371381 chr2:74246613 T/C cg14702570 chr2:74259524 NA -0.3 -5.66 -0.3 3.34e-8 Dialysis-related mortality; LUSC trans rs34421088 0.576 rs2572436 chr8:11099209 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.31 -0.37 1.96e-12 Neuroticism; LUSC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg00800038 chr16:89945340 TCF25 0.59 6.34 0.33 7.52e-10 Skin colour saturation; LUSC cis rs965513 1.000 rs7032019 chr9:100548144 G/A cg13688889 chr9:100608707 NA -0.54 -8.05 -0.4 1.45e-14 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.69 0.63 4.78e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2295359 1.000 rs10889661 chr1:67625309 T/A cg17031739 chr1:67600172 NA 0.36 5.72 0.3 2.35e-8 Psoriasis; LUSC cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.6 0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs78572108 0.925 rs13431578 chr2:42264301 G/A cg00607755 chr2:42274082 PKDCC 0.36 6.48 0.33 3.34e-10 Total body bone mineral density; LUSC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg26597838 chr10:835615 NA 1.21 16.6 0.67 1.46e-45 Eosinophil percentage of granulocytes; LUSC cis rs12421382 0.614 rs12418827 chr11:109390649 G/C cg16359550 chr11:109292809 C11orf87 0.32 5.78 0.3 1.74e-8 Schizophrenia; LUSC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg08847533 chr14:75593920 NEK9 0.86 16.11 0.66 1.35e-43 Height; LUSC trans rs9329221 0.510 rs6995837 chr8:9975675 T/C cg06636001 chr8:8085503 FLJ10661 0.47 6.87 0.35 3.08e-11 Neuroticism; LUSC cis rs6121246 0.559 rs1062794 chr20:30381758 G/C cg13852791 chr20:30311386 BCL2L1 0.95 14.83 0.63 1.45e-38 Mean corpuscular hemoglobin; LUSC cis rs4474465 1.000 rs7935180 chr11:78169785 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.66 -0.3 3.32e-8 Alzheimer's disease (survival time); LUSC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg22535103 chr8:58192502 C8orf71 0.7 7.24 0.37 3.18e-12 Developmental language disorder (linguistic errors); LUSC cis rs208520 0.526 rs9354370 chr6:66808209 C/T cg07460842 chr6:66804631 NA 1.23 26.97 0.83 7.47e-86 Exhaled nitric oxide output; LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg13395646 chr4:1353034 KIAA1530 -0.56 -7.96 -0.4 2.76e-14 Longevity; LUSC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.66 8.0 0.4 2.01e-14 Lung function (FEV1/FVC); LUSC cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg05283184 chr6:79620031 NA -0.57 -12.2 -0.56 1.41e-28 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg04267008 chr7:1944627 MAD1L1 -0.65 -10.04 -0.48 6.92e-21 Bipolar disorder and schizophrenia; LUSC cis rs6840360 0.593 rs59350867 chr4:152695935 G/A cg22705602 chr4:152727874 NA -0.39 -8.37 -0.42 1.58e-15 Intelligence (multi-trait analysis); LUSC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg17800788 chr1:21766015 NBPF3 0.34 6.3 0.33 9.37e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9487051 1.000 rs6568571 chr6:109613252 A/T cg21918786 chr6:109611834 NA -0.39 -6.55 -0.34 2.21e-10 Reticulocyte fraction of red cells; LUSC cis rs11971779 0.680 rs4732379 chr7:139122814 T/C cg07862535 chr7:139043722 LUC7L2 0.6 7.64 0.39 2.25e-13 Diisocyanate-induced asthma; LUSC cis rs4631830 0.869 rs11006207 chr10:51538176 T/C cg20129853 chr10:51489980 NA -0.34 -6.82 -0.35 4.31e-11 Prostate-specific antigen levels; LUSC cis rs7818345 0.967 rs13255946 chr8:19275354 T/C cg11303988 chr8:19266685 CSGALNACT1 0.37 6.99 0.36 1.49e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs2295359 0.824 rs4655679 chr1:67599657 A/G cg12940439 chr1:67600707 NA -0.37 -6.09 -0.32 3.13e-9 Psoriasis; LUSC cis rs1784581 0.802 rs9365359 chr6:162423945 C/A cg17173639 chr6:162384350 PARK2 0.66 11.73 0.54 7.75e-27 Itch intensity from mosquito bite; LUSC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg09555818 chr19:45449301 APOC2 -0.47 -8.56 -0.42 4.29e-16 Blood protein levels; LUSC trans rs34844492 0.744 rs17072704 chr3:65271885 C/T cg21674010 chr15:58844583 LIPC 0.67 6.45 0.33 3.93e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.71 9.55 0.46 2.84e-19 Gut microbiome composition (summer); LUSC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg22907277 chr7:1156413 C7orf50 -0.47 -7.36 -0.37 1.48e-12 Longevity;Endometriosis; LUSC cis rs6840360 0.615 rs6831810 chr4:152461995 A/G cg22705602 chr4:152727874 NA -0.32 -6.47 -0.33 3.41e-10 Intelligence (multi-trait analysis); LUSC cis rs11690935 0.959 rs6709156 chr2:172591944 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.42 -0.62 5.29e-37 Schizophrenia; LUSC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg07701084 chr6:150067640 NUP43 0.53 7.8 0.39 7.88e-14 Lung cancer; LUSC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg13607699 chr17:42295918 UBTF 0.47 7.45 0.38 8.21e-13 Total body bone mineral density; LUSC cis rs13315871 0.929 rs13080398 chr3:58300282 A/G cg20936604 chr3:58311152 NA -0.71 -6.73 -0.35 7.52e-11 Cholesterol, total; LUSC cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg08999081 chr20:33150536 PIGU 0.45 8.16 0.41 6.79e-15 Coronary artery disease; LUSC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.66 0.39 2.01e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg14007221 chr9:37651177 FRMPD1 0.42 6.43 0.33 4.54e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs1670533 0.932 rs13140341 chr4:1054235 T/C cg27284194 chr4:1044797 NA 0.59 8.69 0.43 1.6e-16 Recombination rate (females); LUSC cis rs7937682 1.000 rs505372 chr11:111507189 A/C cg19812747 chr11:111475976 SIK2 -0.48 -6.55 -0.34 2.16e-10 Primary sclerosing cholangitis; LUSC trans rs853679 0.607 rs35072899 chr6:28281541 C/T cg06606381 chr12:133084897 FBRSL1 -0.99 -9.27 -0.45 2.45e-18 Depression; LUSC cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg22782873 chr19:19639568 YJEFN3 -0.53 -6.48 -0.33 3.38e-10 Bipolar disorder; LUSC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg14416269 chr4:6271139 WFS1 -0.47 -10.29 -0.49 9.47e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7587476 0.682 rs13009646 chr2:215691259 T/A cg04004882 chr2:215674386 BARD1 0.48 6.37 0.33 6.34e-10 Neuroblastoma; LUSC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg15468180 chr1:107600409 PRMT6 0.36 5.88 0.31 9.93e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.79e-8 Depression; LUSC cis rs1957429 0.614 rs1957416 chr14:65369329 C/T cg23373153 chr14:65346875 NA -1.01 -8.51 -0.42 6.09e-16 Pediatric areal bone mineral density (radius); LUSC cis rs5769707 0.967 rs8141807 chr22:50043738 C/G cg05373962 chr22:49881684 NA -0.44 -10.5 -0.5 1.81e-22 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg17330251 chr7:94953956 PON1 -0.37 -5.96 -0.31 6.32e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg24813613 chr7:1882135 MAD1L1 -0.46 -7.82 -0.39 7.09e-14 Bipolar disorder and schizophrenia; LUSC cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg00012203 chr2:219082015 ARPC2 0.76 13.61 0.6 7.57e-34 Colorectal cancer; LUSC cis rs11190604 1.000 rs1080698 chr10:102295114 G/T cg07080220 chr10:102295463 HIF1AN 0.68 9.27 0.45 2.37e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs877282 0.838 rs34912955 chr10:772222 T/C cg17470449 chr10:769945 NA 0.53 7.31 0.37 1.98e-12 Uric acid levels; LUSC cis rs4253772 0.872 rs45576734 chr22:46638365 A/G cg24881330 chr22:46731750 TRMU 0.63 5.85 0.31 1.15e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC cis rs1577917 1.000 rs34581302 chr6:86705948 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.94 -0.35 2.06e-11 Response to antipsychotic treatment; LUSC cis rs4363385 0.818 rs4845512 chr1:152995241 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.11 -0.36 7.08e-12 Inflammatory skin disease; LUSC cis rs7193541 0.684 rs9929496 chr16:74668473 G/A cg01733217 chr16:74700730 RFWD3 0.98 21.94 0.77 1.05e-66 Multiple myeloma; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg24101359 chr6:42928495 GNMT 0.35 5.8 0.3 1.5e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6500395 0.962 rs11647046 chr16:48623217 T/C cg04672837 chr16:48644449 N4BP1 0.49 7.02 0.36 1.26e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg02018176 chr4:1364513 KIAA1530 0.53 9.2 0.45 3.96e-18 Obesity-related traits; LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg19318889 chr4:1322082 MAEA 0.42 6.94 0.36 2.01e-11 Obesity-related traits; LUSC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg10792982 chr14:105748885 BRF1 0.5 9.14 0.45 6.23e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs7173743 0.756 rs4539564 chr15:79128499 G/A cg00540400 chr15:79124168 NA 0.35 5.99 0.31 5.29e-9 Coronary artery disease; LUSC cis rs929354 0.772 rs1182438 chr7:157027438 G/A cg05182265 chr7:156933206 UBE3C 0.59 9.67 0.47 1.17e-19 Body mass index; LUSC cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg24130564 chr14:104152367 KLC1 -0.47 -6.82 -0.35 4.31e-11 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg04455712 chr21:45112962 RRP1B 0.44 8.3 0.41 2.56e-15 Mean corpuscular volume; LUSC cis rs909341 0.830 rs1623866 chr20:62333022 G/A cg09650180 chr20:62225654 GMEB2 -0.45 -5.83 -0.3 1.32e-8 Atopic dermatitis; LUSC cis rs3806843 0.932 rs2563257 chr5:140140529 A/G cg26395211 chr5:140044315 WDR55 0.38 5.77 0.3 1.77e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs753778 0.962 rs4961341 chr8:142235154 G/T cg18755752 chr8:142205143 DENND3 -0.51 -6.86 -0.35 3.38e-11 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4595586 0.525 rs3914597 chr12:39388693 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg19920283 chr7:105172520 RINT1 0.62 6.94 0.36 2.04e-11 Bipolar disorder (body mass index interaction); LUSC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg18827107 chr12:86230957 RASSF9 -0.46 -6.97 -0.36 1.74e-11 Major depressive disorder; LUSC cis rs1030268 0.620 rs2160746 chr7:133478204 G/C cg10665199 chr7:133106180 EXOC4 0.54 5.89 0.31 9.6e-9 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg11494091 chr17:61959527 GH2 0.64 13.62 0.6 6.4e-34 Prudent dietary pattern; LUSC cis rs6942756 0.774 rs2566885 chr7:128917587 C/T cg02491457 chr7:128862824 NA 0.49 7.23 0.37 3.26e-12 White matter hyperintensity burden; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg06404838 chr11:117015391 PAFAH1B2 -0.44 -6.69 -0.34 9.7e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg23887609 chr12:130822674 PIWIL1 0.49 7.34 0.37 1.64e-12 Menopause (age at onset); LUSC cis rs9687065 1.000 rs17722209 chr5:148406386 A/G cg23229984 chr5:148520753 ABLIM3 -0.38 -5.79 -0.3 1.58e-8 Diastolic blood pressure; LUSC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.31 0.56 5.66e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3020736 0.500 rs5996111 chr22:42493902 C/T cg15557168 chr22:42548783 NA 0.45 6.76 0.35 6.2e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18540374 chr18:9102459 NDUFV2 -0.45 -6.71 -0.34 8.12e-11 Triglycerides; LUSC cis rs36093844 0.752 rs17744606 chr11:85565450 C/T cg25872744 chr11:85566296 CCDC83 -0.45 -5.78 -0.3 1.68e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg17845761 chr1:175162550 KIAA0040 -0.31 -6.01 -0.31 4.76e-9 Alcohol dependence; LUSC cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg26597838 chr10:835615 NA 0.49 6.76 0.35 6.03e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.58 0.34 1.86e-10 Lung cancer; LUSC cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg08213375 chr14:104286397 PPP1R13B 0.52 10.25 0.49 1.3e-21 Schizophrenia; LUSC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg26314531 chr2:26401878 FAM59B -0.68 -9.1 -0.45 8.35e-18 Gut microbiome composition (summer); LUSC cis rs6754311 0.551 rs9287442 chr2:136522710 A/G cg07169764 chr2:136633963 MCM6 -0.74 -10.0 -0.48 8.98e-21 Mosquito bite size; LUSC cis rs11190604 0.697 rs4559619 chr10:102199884 C/T cg07080220 chr10:102295463 HIF1AN -0.59 -8.1 -0.41 1.02e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg16339924 chr4:17578868 LAP3 0.54 8.32 0.41 2.32e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.17 -0.41 6.38e-15 Axial length; LUSC cis rs2667011 0.818 rs1397709 chr2:160852712 G/T cg06573604 chr2:160760825 LY75 -0.5 -6.5 -0.33 3.01e-10 Bilirubin levels; LUSC cis rs734999 0.566 rs4648658 chr1:2560882 G/A cg18932078 chr1:2524107 MMEL1 -0.28 -6.06 -0.31 3.77e-9 Ulcerative colitis; LUSC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg18350739 chr11:68623251 NA 0.39 7.15 0.36 5.51e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs55665837 1.000 rs11023224 chr11:14457739 G/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 6.93e-13 Vitamin D levels; LUSC cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg05283184 chr6:79620031 NA -0.57 -11.82 -0.54 3.53e-27 Intelligence (multi-trait analysis); LUSC cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg06064525 chr11:970664 AP2A2 -0.36 -7.17 -0.37 4.89e-12 Alzheimer's disease (late onset); LUSC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg07936489 chr17:37558343 FBXL20 -0.7 -9.54 -0.46 3.1400000000000002e-19 Glomerular filtration rate (creatinine); LUSC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs2637266 0.783 rs864676 chr10:78509385 A/G cg18941641 chr10:78392320 NA 0.39 7.14 0.36 5.99e-12 Pulmonary function; LUSC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg26408565 chr15:76604113 ETFA -0.5 -7.98 -0.4 2.41e-14 Blood metabolite levels; LUSC cis rs9420 0.961 rs11607056 chr11:57496820 C/T cg23127183 chr11:57508653 C11orf31 -0.58 -8.91 -0.44 3.41e-17 Schizophrenia; LUSC cis rs10979 0.571 rs9386039 chr6:143916992 A/T cg25407410 chr6:143891975 LOC285740 0.56 6.8 0.35 4.88e-11 Hypospadias; LUSC cis rs1322512 1.000 rs1744379 chr6:152942844 C/A cg27316956 chr6:152958899 SYNE1 -0.35 -5.79 -0.3 1.66e-8 Tonometry; LUSC cis rs6554196 0.508 rs999020 chr4:55524304 T/C cg18836493 chr4:55524333 KIT -0.43 -7.43 -0.38 9.34e-13 Monocyte count; LUSC cis rs208520 0.690 rs2144081 chr6:66824972 G/A cg07460842 chr6:66804631 NA -1.15 -18.29 -0.71 2.9e-52 Exhaled nitric oxide output; LUSC trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg27661571 chr11:113659931 NA -0.52 -6.19 -0.32 1.73e-9 Hip circumference adjusted for BMI; LUSC trans rs941408 1.000 rs1736176 chr19:2790394 G/A cg22153745 chr1:153894579 GATAD2B -0.53 -8.1 -0.41 1.07e-14 Total cholesterol levels; LUSC cis rs7315438 0.578 rs2384649 chr12:115884454 C/T cg24172291 chr12:115889509 NA -0.33 -5.71 -0.3 2.55e-8 Colorectal cancer; LUSC cis rs8114671 0.586 rs734111 chr20:33533736 A/C cg07148914 chr20:33460835 GGT7 0.56 8.52 0.42 5.56e-16 Height; LUSC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg18357526 chr6:26021779 HIST1H4A 0.41 6.02 0.31 4.54e-9 Intelligence (multi-trait analysis); LUSC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.6 -8.59 -0.43 3.38e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6669072 0.605 rs34304726 chr1:91257997 T/C cg08895590 chr1:91227319 NA -0.28 -5.99 -0.31 5.47e-9 Cognitive function; LUSC trans rs2228479 0.541 rs9806913 chr16:89953773 A/G cg24644049 chr4:85504048 CDS1 0.69 7.03 0.36 1.15e-11 Skin colour saturation; LUSC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg04369109 chr6:150039330 LATS1 -0.53 -7.9 -0.4 3.96e-14 Lung cancer; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg13047869 chr3:10149882 C3orf24 -0.64 -7.77 -0.39 1e-13 Alzheimer's disease; LUSC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.09e-12 Mean platelet volume; LUSC cis rs6840360 1.000 rs6535819 chr4:152651503 A/G cg22705602 chr4:152727874 NA -0.3 -6.44 -0.33 4.19e-10 Intelligence (multi-trait analysis); LUSC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg21433313 chr16:3507492 NAT15 0.7 11.47 0.53 6.47e-26 Tuberculosis; LUSC cis rs6918586 0.658 rs198838 chr6:26113340 C/T cg17691542 chr6:26056736 HIST1H1C -0.41 -6.04 -0.31 4.01e-9 Schizophrenia; LUSC cis rs9611519 1.000 rs2057070 chr22:41564287 T/C cg03806693 chr22:41940476 POLR3H -0.55 -7.61 -0.38 2.84e-13 Neuroticism; LUSC cis rs11955175 1.000 rs78855960 chr5:40657221 C/G cg05478818 chr5:40835740 RPL37 0.7 5.72 0.3 2.37e-8 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs6840360 0.571 rs1473305 chr4:152511721 T/G cg22705602 chr4:152727874 NA -0.32 -6.54 -0.34 2.28e-10 Intelligence (multi-trait analysis); LUSC cis rs7904985 0.961 rs12355013 chr10:88114538 A/G cg07322936 chr10:88137208 NA 0.54 6.97 0.36 1.7e-11 Barrett's esophagus; LUSC cis rs17030434 0.906 rs4145339 chr4:154710481 C/T cg14289246 chr4:154710475 SFRP2 -0.52 -6.66 -0.34 1.11e-10 Electrocardiographic conduction measures; LUSC trans rs2228479 0.702 rs17233176 chr16:89832751 G/C cg24644049 chr4:85504048 CDS1 0.88 7.53 0.38 4.81e-13 Skin colour saturation; LUSC trans rs853679 0.517 rs9393895 chr6:28127621 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.19e-9 Depression; LUSC cis rs9807989 0.773 rs72823661 chr2:102968716 G/A cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs308403 0.530 rs13135766 chr4:123664427 C/G cg10495464 chr4:123653540 BBS12;LOC729338 -0.75 -9.89 -0.48 2.1e-20 Blood protein levels; LUSC cis rs6545883 0.965 rs7421663 chr2:61753786 C/T cg15711740 chr2:61764176 XPO1 -0.5 -7.97 -0.4 2.55e-14 Tuberculosis; LUSC cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg00277334 chr10:82204260 NA -0.95 -19.99 -0.74 5.2e-59 Post bronchodilator FEV1; LUSC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg22875332 chr1:76189707 ACADM 0.76 10.04 0.48 6.77e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg13206674 chr6:150067644 NUP43 0.6 9.54 0.46 3.08e-19 Lung cancer; LUSC cis rs6445967 0.530 rs12486031 chr3:58409679 G/A cg23715586 chr3:58305044 RPP14 0.42 7.14 0.36 5.81e-12 Platelet count; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg18765753 chr7:1198926 ZFAND2A -0.53 -9.68 -0.47 1.07e-19 Longevity;Endometriosis; LUSC cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg08213375 chr14:104286397 PPP1R13B 0.54 11.03 0.52 2.41e-24 Schizophrenia; LUSC cis rs17125944 0.505 rs75838476 chr14:53242362 G/A cg13660082 chr14:53194042 PSMC6 -0.78 -6.81 -0.35 4.55e-11 Alzheimer's disease (late onset); LUSC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.81 0.75 2.85e-62 Homoarginine levels; LUSC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg00255919 chr5:131827918 IRF1 0.35 6.75 0.35 6.41e-11 Breast cancer;Mosquito bite size; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg04369109 chr6:150039330 LATS1 -0.54 -7.83 -0.39 6.34e-14 Lung cancer; LUSC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg02807482 chr3:125708958 NA -0.54 -6.65 -0.34 1.16e-10 Blood pressure (smoking interaction); LUSC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.47 -7.36 -0.37 1.43e-12 Alzheimer's disease (late onset); LUSC trans rs1908814 0.516 rs58869268 chr8:11797095 G/C cg15556689 chr8:8085844 FLJ10661 0.58 8.74 0.43 1.19e-16 Neuroticism; LUSC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg03264133 chr6:25882463 NA -0.35 -5.72 -0.3 2.39e-8 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg06634786 chr22:41940651 POLR3H -0.5 -5.89 -0.31 9.64e-9 Vitiligo; LUSC cis rs8060686 0.641 rs9938553 chr16:68183064 T/A cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs34638657 0.646 rs72628279 chr16:82199664 A/C cg09439754 chr16:82129088 HSD17B2 -0.4 -6.73 -0.35 7.52e-11 Lung adenocarcinoma; LUSC cis rs11031096 0.679 rs12292515 chr11:4206385 T/G cg18678763 chr11:4115507 RRM1 -0.41 -5.75 -0.3 2.02e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27109131 chr3:14165888 TMEM43;CHCHD4 -0.42 -5.97 -0.31 6.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg20200200 chr1:18807388 KLHDC7A -0.33 -6.82 -0.35 4.36e-11 Breast cancer; LUSC cis rs6750047 0.625 rs336036 chr2:38261143 C/T cg07380506 chr2:38303506 CYP1B1 -0.44 -6.18 -0.32 1.91e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs4631830 0.900 rs4630241 chr10:51532751 G/A cg16070123 chr10:51489643 NA -0.52 -8.25 -0.41 3.65e-15 Prostate-specific antigen levels; LUSC cis rs10761482 0.861 rs1473404 chr10:62102316 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg06634786 chr22:41940651 POLR3H 0.51 5.95 0.31 6.94e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7577696 0.597 rs17011801 chr2:32298072 A/T cg02381751 chr2:32503542 YIPF4 -0.51 -6.88 -0.35 2.89e-11 Inflammatory biomarkers; LUSC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg02038168 chr22:39784481 NA -0.49 -7.89 -0.4 4.5e-14 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg09509183 chr1:209979624 IRF6 0.52 6.21 0.32 1.61e-9 Cleft lip with or without cleft palate; LUSC cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.99 0.36 1.46e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs478304 0.718 rs61744384 chr11:65387378 T/A cg27068330 chr11:65405492 SIPA1 -0.64 -9.02 -0.44 1.54e-17 Acne (severe); LUSC cis rs34779708 0.931 rs4934535 chr10:35432721 G/T cg04310649 chr10:35416472 CREM -0.43 -6.64 -0.34 1.27e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4820539 1.000 rs3827316 chr22:23468538 T/C cg21100191 chr22:23484243 RTDR1 0.91 15.54 0.65 2.29e-41 Bone mineral density; LUSC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.44e-9 Aortic root size; LUSC cis rs9372253 0.967 rs9400379 chr6:110713783 A/G cg19196401 chr6:110721138 DDO -0.47 -8.84 -0.44 5.67e-17 Platelet distribution width; LUSC cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg12310025 chr6:25882481 NA -0.5 -9.06 -0.44 1.09e-17 Blood metabolite levels; LUSC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg15017067 chr4:17643749 FAM184B 0.35 5.76 0.3 1.96e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg12257692 chr3:49977190 RBM6 -0.26 -7.32 -0.37 1.82e-12 Body mass index; LUSC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg05472934 chr7:22766657 IL6 0.54 8.47 0.42 7.64e-16 Lung cancer; LUSC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg17179660 chr6:151773299 C6orf211;RMND1 -0.46 -6.73 -0.35 7.2e-11 Menarche (age at onset); LUSC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg07636037 chr3:49044803 WDR6 0.44 6.38 0.33 5.9e-10 Resting heart rate; LUSC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg27532560 chr4:187881888 NA -0.35 -5.83 -0.3 1.31e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg19875535 chr5:140030758 IK 0.48 7.76 0.39 1.01e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs8060686 0.641 rs8058690 chr16:68136622 T/G cg26727032 chr16:67993705 SLC12A4 -0.42 -5.79 -0.3 1.62e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs757081 0.606 rs679201 chr11:17200891 T/C cg15432903 chr11:17409602 KCNJ11 -0.38 -5.89 -0.31 9.56e-9 Systolic blood pressure; LUSC cis rs11031096 0.678 rs1442727 chr11:4188188 G/T cg18678763 chr11:4115507 RRM1 0.41 5.9 0.31 9.15e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.53 -8.11 -0.41 9.55e-15 Lymphocyte counts; LUSC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg20933634 chr6:27740509 NA 0.43 5.93 0.31 7.46e-9 Parkinson's disease; LUSC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs870825 0.616 rs4263438 chr4:185624238 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs1949733 0.701 rs2631735 chr4:8476118 A/G cg13073564 chr4:8508604 NA -0.44 -8.26 -0.41 3.47e-15 Response to antineoplastic agents; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs6733011 0.628 rs10188156 chr2:99465875 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.76 -0.35 6.12e-11 Bipolar disorder; LUSC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.65 7.99 0.4 2.24e-14 Lung function (FEV1/FVC); LUSC cis rs568617 0.903 rs601863 chr11:65646557 C/A cg19792802 chr11:65647270 CTSW -0.41 -6.28 -0.32 1.05e-9 Crohn's disease; LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg27588902 chr6:42928151 GNMT -0.3 -6.6 -0.34 1.57e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7100689 0.646 rs7919380 chr10:82133380 C/T cg00277334 chr10:82204260 NA -0.52 -7.74 -0.39 1.21e-13 Post bronchodilator FEV1; LUSC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg03709012 chr19:19516395 GATAD2A -0.76 -11.99 -0.55 8.98e-28 Tonsillectomy; LUSC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg12311346 chr5:56204834 C5orf35 -0.97 -13.98 -0.61 2.89e-35 Initial pursuit acceleration; LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg25036284 chr2:26402008 FAM59B -0.74 -10.65 -0.5 5.23e-23 Gut microbiome composition (summer); LUSC cis rs9914544 0.545 rs8067882 chr17:18807131 A/G cg26378065 chr17:18585709 ZNF286B 0.41 5.75 0.3 2.01e-8 Educational attainment (years of education); LUSC cis rs7267979 1.000 rs6050573 chr20:25366065 C/G cg08601574 chr20:25228251 PYGB 0.42 6.5 0.33 3e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 0.39 6.67 0.34 1.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9359856 0.956 rs6912680 chr6:90300010 T/G cg13799429 chr6:90582589 CASP8AP2 0.56 6.44 0.33 4.08e-10 Bipolar disorder; LUSC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.57 8.95 0.44 2.45e-17 Menopause (age at onset); LUSC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.43 6.07 0.32 3.55e-9 Height; LUSC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg12564285 chr5:131593104 PDLIM4 0.32 5.68 0.3 3.01e-8 Breast cancer;Mosquito bite size; LUSC cis rs1559088 0.948 rs7257858 chr19:33591231 T/C cg27124370 chr19:33622961 WDR88 0.57 7.41 0.38 1.03e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11648796 0.757 rs66649828 chr16:766078 A/G cg27144592 chr16:783916 NARFL 0.65 10.0 0.48 8.94e-21 Height; LUSC cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg07636037 chr3:49044803 WDR6 -0.68 -8.84 -0.44 5.66e-17 Menarche (age at onset); LUSC cis rs1153858 1.000 rs2461702 chr15:45647427 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.31 0.41 2.49e-15 Homoarginine levels; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg02675527 chr2:114030824 PAX8;LOC440839 0.36 5.71 0.3 2.55e-8 Lymphocyte counts; LUSC trans rs11241130 0.669 rs26043 chr5:111013218 A/C cg24626752 chr13:88328274 SLITRK5 0.72 6.13 0.32 2.43e-9 Obesity-related traits; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg07703079 chr11:430292 ANO9 0.7 7.12 0.36 6.72e-12 Body mass index; LUSC cis rs3741151 1.000 rs7125978 chr11:73039229 G/A cg17517138 chr11:73019481 ARHGEF17 0.97 9.08 0.44 1e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg05585544 chr11:47624801 NA -0.42 -7.36 -0.37 1.45e-12 Subjective well-being; LUSC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg25174290 chr11:3078921 CARS 0.59 9.44 0.46 6.52e-19 Longevity; LUSC cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg05043794 chr9:111880884 C9orf5 -0.35 -7.16 -0.36 5.05e-12 Menarche (age at onset); LUSC cis rs11758351 1.000 rs75921373 chr6:26191843 C/T cg01420254 chr6:26195488 NA 0.7 7.46 0.38 7.56e-13 Gout;Renal underexcretion gout; LUSC cis rs2742417 0.603 rs2742374 chr3:45784082 T/C cg04837898 chr3:45731254 SACM1L -0.46 -7.46 -0.38 7.62e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg04944784 chr2:26401820 FAM59B -0.7 -9.77 -0.47 5.32e-20 Gut microbiome composition (summer); LUSC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg20135002 chr11:47629003 NA -0.43 -7.04 -0.36 1.12e-11 Subjective well-being; LUSC cis rs12950390 0.853 rs56363619 chr17:45854621 T/C cg06532163 chr17:45867833 NA 0.34 6.34 0.33 7.6e-10 IgG glycosylation; LUSC cis rs79387448 0.745 rs72995626 chr2:103162580 T/C cg09003973 chr2:102972529 NA 0.89 8.62 0.43 2.69e-16 Gut microbiota (bacterial taxa); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg17598997 chr1:45672616 ZSWIM5 0.39 6.55 0.34 2.15e-10 Triglycerides; LUSC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg21724239 chr8:58056113 NA 0.66 7.4 0.38 1.14e-12 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg11764359 chr7:65958608 NA -0.7 -10.95 -0.51 4.95e-24 Aortic root size; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg03732007 chr1:2071316 PRKCZ -0.53 -9.47 -0.46 5.11e-19 Height; LUSC cis rs9818941 1.000 rs9818941 chr3:157686457 G/A cg08654915 chr3:157813417 NA -0.24 -6.08 -0.32 3.37e-9 Height; LUSC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg13206674 chr6:150067644 NUP43 0.59 9.47 0.46 5.47e-19 Lung cancer; LUSC trans rs877282 0.898 rs11253352 chr10:766598 C/A cg13042288 chr15:90349979 ANPEP -0.47 -6.61 -0.34 1.51e-10 Uric acid levels; LUSC cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg13319975 chr6:146136371 FBXO30 0.45 6.99 0.36 1.51e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2486288 0.656 rs2413771 chr15:45553140 A/G cg14582100 chr15:45693742 SPATA5L1 -0.42 -7.72 -0.39 1.39e-13 Glomerular filtration rate; LUSC cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg05472934 chr7:22766657 IL6 0.38 6.04 0.31 4.02e-9 Lung cancer; LUSC cis rs11677416 1.000 rs2856836 chr2:113532083 A/G cg27083787 chr2:113543245 IL1A 0.48 7.39 0.37 1.17e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs56283067 0.847 rs2128543 chr6:44685552 G/A cg20913747 chr6:44695427 NA -0.44 -7.32 -0.37 1.9e-12 Total body bone mineral density; LUSC trans rs2204008 0.666 rs67792345 chr12:38204698 T/C cg06521331 chr12:34319734 NA -0.41 -6.13 -0.32 2.49e-9 Bladder cancer; LUSC cis rs2075165 0.935 rs933489 chr1:156235120 T/C cg20302342 chr1:156215951 PAQR6 0.32 6.06 0.31 3.57e-9 Tonsillectomy; LUSC cis rs8062405 1.000 rs56404918 chr16:28846840 T/G cg09754948 chr16:28834200 ATXN2L 0.42 6.11 0.32 2.78e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs9291683 0.525 rs12506455 chr4:10031569 T/A cg26043149 chr18:55253948 FECH 0.51 7.52 0.38 4.96e-13 Bone mineral density; LUSC trans rs61931739 0.534 rs35056575 chr12:34142914 A/T cg13010199 chr12:38710504 ALG10B 0.55 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs13092825 1.000 rs13074313 chr3:113273634 A/C cg18753928 chr3:113234510 CCDC52 0.38 5.75 0.3 2.02e-8 Dental caries; LUSC cis rs3820928 0.904 rs2894623 chr2:227766112 T/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.76 -0.39 1.07e-13 Pulmonary function; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25470731 chr5:132112891 SEPT8 0.71 6.52 0.34 2.54e-10 Cognitive performance; LUSC cis rs7584330 0.554 rs3751110 chr2:238427142 T/C cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC cis rs1371867 0.764 rs1020171 chr8:101288610 T/C cg06002616 chr8:101225028 SPAG1 -0.46 -7.49 -0.38 6.32e-13 Atrioventricular conduction; LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs4144743 1.000 rs7208170 chr17:45330759 G/A cg18085866 chr17:45331354 ITGB3 -0.74 -7.72 -0.39 1.38e-13 Body mass index; LUSC cis rs7538876 0.903 rs7528427 chr1:17746273 C/T cg07965774 chr1:17746286 RCC2 0.33 6.2 0.32 1.64e-9 Basal cell carcinoma; LUSC cis rs11158026 0.757 rs8012152 chr14:55425567 T/C cg04306507 chr14:55594613 LGALS3 0.33 6.4 0.33 5.17e-10 Parkinson's disease; LUSC cis rs1559088 0.847 rs3760891 chr19:33599708 C/T cg17764715 chr19:33622953 WDR88 0.6 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg24692254 chr21:30365293 RNF160 0.87 16.63 0.67 1.17e-45 Dental caries; LUSC cis rs4654899 0.897 rs10916856 chr1:21082074 A/C cg01072550 chr1:21505969 NA -0.48 -7.09 -0.36 7.8e-12 Superior frontal gyrus grey matter volume; LUSC cis rs259282 0.851 rs174083 chr19:33141180 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.87 14.26 0.62 2.23e-36 Schizophrenia; LUSC cis rs4663866 0.901 rs34040298 chr2:239191607 T/C cg16914508 chr2:239161102 PER2 0.69 7.62 0.38 2.58e-13 Irritable bowel syndrome; LUSC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg02534363 chr3:47050950 NBEAL2 0.35 5.75 0.3 2.07e-8 Colorectal cancer; LUSC cis rs8113142 0.614 rs11083646 chr19:29214739 C/T cg04546413 chr19:29218101 NA 0.43 5.93 0.31 7.76e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs2404602 0.684 rs57682236 chr15:76868478 G/A cg23625390 chr15:77176239 SCAPER -0.66 -9.83 -0.47 3.49e-20 Blood metabolite levels; LUSC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg16346588 chr10:242978 ZMYND11 0.41 5.9 0.31 9.1e-9 Psychosis in Alzheimer's disease; LUSC cis rs5769707 0.837 rs1573726 chr22:50032872 G/A cg05373962 chr22:49881684 NA -0.41 -9.99 -0.48 9.53e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2204008 0.594 rs11531211 chr12:37998007 T/G cg26384229 chr12:38710491 ALG10B -0.81 -13.32 -0.59 9.42e-33 Bladder cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17735028 chr1:19283102 IFFO2 -0.37 -6.0 -0.31 5.25e-9 Electrocardiographic conduction measures; LUSC cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.74 -0.39 1.2e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.21 -0.37 3.86e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs12579753 1.000 rs10862373 chr12:82250657 A/G cg21231944 chr12:82153410 PPFIA2 -0.38 -5.83 -0.3 1.28e-8 Resting heart rate; LUSC cis rs2637266 1.000 rs7897348 chr10:78359620 G/A cg18941641 chr10:78392320 NA 0.38 7.08 0.36 8.29e-12 Pulmonary function; LUSC trans rs1997103 0.954 rs9649780 chr7:55411741 A/C cg20935933 chr6:143382018 AIG1 0.51 7.43 0.38 8.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9303401 0.659 rs12935851 chr17:56600244 C/A cg25039879 chr17:56429692 SUPT4H1 0.69 9.17 0.45 5.1e-18 Cognitive test performance; LUSC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg03060546 chr3:49711283 APEH -0.61 -6.86 -0.35 3.31e-11 Menarche (age at onset); LUSC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs1728785 0.818 rs1170430 chr16:68604954 T/C cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg16606324 chr3:10149918 C3orf24 0.6 8.59 0.43 3.26e-16 Alzheimer's disease; LUSC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg16339924 chr4:17578868 LAP3 0.51 7.63 0.39 2.41e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5771069 0.896 rs137862 chr22:50446550 C/A cg27467552 chr22:50353597 PIM3 -0.41 -6.97 -0.36 1.75e-11 Ulcerative colitis; LUSC cis rs2760061 0.545 rs1636196 chr1:228204030 A/G cg04850211 chr1:228464232 OBSCN -0.36 -6.12 -0.32 2.69e-9 Diastolic blood pressure; LUSC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.97 0.36 1.7e-11 Intelligence (multi-trait analysis); LUSC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg21251018 chr6:28226885 NKAPL 0.31 5.84 0.3 1.22e-8 Pubertal anthropometrics; LUSC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg07777115 chr5:623756 CEP72 -0.46 -5.9 -0.31 9.16e-9 Obesity-related traits; LUSC cis rs2404602 0.692 rs10444858 chr15:76962504 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.29e-12 Blood metabolite levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04434696 chr7:128379324 CALU 0.7 6.03 0.31 4.35e-9 Cognitive performance; LUSC trans rs11992162 0.573 rs13264994 chr8:11782759 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.76 -0.35 6.16e-11 Monocyte count; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg06680201 chr11:71824165 C11orf51 0.36 6.22 0.32 1.47e-9 Tuberculosis; LUSC cis rs2932538 0.922 rs12401734 chr1:113071834 A/G cg22162597 chr1:113214053 CAPZA1 0.7 10.07 0.48 5.48e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs453301 0.598 rs10104303 chr8:8834528 A/T cg11608241 chr8:8085544 FLJ10661 0.39 5.64 0.3 3.56e-8 Joint mobility (Beighton score); LUSC cis rs713587 0.525 rs11687089 chr2:25082926 T/C cg04586622 chr2:25135609 ADCY3 0.36 7.3 0.37 2.1e-12 Body mass index in non-asthmatics; LUSC cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg08085267 chr17:45401833 C17orf57 0.45 6.75 0.35 6.5e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1124376 0.935 rs9855900 chr3:20147172 C/T cg05072819 chr3:20081367 KAT2B 0.66 7.53 0.38 4.7e-13 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg06740227 chr12:86229804 RASSF9 0.38 6.06 0.31 3.6e-9 Major depressive disorder; LUSC cis rs9921338 0.961 rs7198849 chr16:11373301 C/T cg00044050 chr16:11439710 C16orf75 -0.48 -6.73 -0.35 7.59e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg06873352 chr17:61820015 STRADA 0.73 13.07 0.58 8.33e-32 Prudent dietary pattern; LUSC cis rs9788682 0.747 rs8043009 chr15:78908154 G/C cg24631222 chr15:78858424 CHRNA5 0.62 8.76 0.43 1.01e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2404602 0.709 rs11072597 chr15:76763514 C/A cg23625390 chr15:77176239 SCAPER -0.62 -9.51 -0.46 3.79e-19 Blood metabolite levels; LUSC cis rs6690583 0.623 rs12041012 chr1:85515644 G/A cg11262906 chr1:85462892 MCOLN2 0.69 6.22 0.32 1.51e-9 Serum sulfate level; LUSC cis rs3768617 0.510 rs6424885 chr1:183066254 T/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.71 0.51 3.22e-23 Fuchs's corneal dystrophy; LUSC cis rs67460515 0.567 rs34691229 chr3:160876897 G/T cg03342759 chr3:160939853 NMD3 -0.48 -6.64 -0.34 1.27e-10 Parkinson's disease; LUSC cis rs9914544 0.545 rs8067882 chr17:18807131 A/G cg26306683 chr17:18585705 ZNF286B 0.42 5.95 0.31 6.65e-9 Educational attainment (years of education); LUSC cis rs3942852 0.868 rs7118232 chr11:48106274 T/C cg20307385 chr11:47447363 PSMC3 0.53 6.25 0.32 1.27e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs7312933 0.584 rs7974654 chr12:42630466 C/A cg17420585 chr12:42539391 GXYLT1 -0.34 -6.52 -0.34 2.61e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs497273 0.512 rs1177585 chr12:121325321 C/T cg02419362 chr12:121203948 SPPL3 -0.43 -7.83 -0.39 6.7e-14 Systemic lupus erythematosus; LUSC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.14 17.32 0.69 2.01e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs7759001 0.857 rs1883404 chr6:27350381 A/T cg18711553 chr6:27366782 ZNF391 -0.41 -5.96 -0.31 6.24e-9 Glomerular filtration rate (creatinine); LUSC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg10523679 chr1:76189770 ACADM -0.85 -11.39 -0.53 1.25e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg24296786 chr1:45957014 TESK2 0.54 8.26 0.41 3.53e-15 High light scatter reticulocyte count; LUSC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg12463550 chr7:65579703 CRCP 0.51 7.34 0.37 1.6e-12 Aortic root size; LUSC trans rs2694917 0.632 rs2638315 chr12:56865056 C/G cg19051015 chr17:46697414 NA 0.41 6.44 0.33 4.09e-10 Blood metabolite ratios; LUSC cis rs4132509 1.000 rs10927050 chr1:243805907 A/G cg21452805 chr1:244014465 NA 0.52 6.08 0.32 3.34e-9 RR interval (heart rate); LUSC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs7786877 0.626 rs11770389 chr7:100221218 T/G cg20848291 chr7:100343083 ZAN -0.57 -6.93 -0.35 2.14e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg09904177 chr6:26538194 HMGN4 -0.75 -6.61 -0.34 1.51e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg20476274 chr7:133979776 SLC35B4 0.83 15.15 0.64 7.91e-40 Mean platelet volume; LUSC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 9.91e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7481584 0.646 rs434114 chr11:3050210 A/G cg05729581 chr11:3078854 CARS 0.39 5.7 0.3 2.67e-8 Calcium levels; LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg16405210 chr4:1374714 KIAA1530 -0.83 -13.64 -0.6 5.54e-34 Longevity; LUSC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg02772935 chr3:125709198 NA -0.47 -6.08 -0.32 3.22e-9 Blood pressure (smoking interaction); LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg20887711 chr4:1340912 KIAA1530 0.49 7.21 0.37 3.85e-12 Obesity-related traits; LUSC cis rs1215050 0.791 rs1215055 chr4:98865454 C/T cg05340658 chr4:99064831 C4orf37 -0.44 -6.95 -0.36 1.94e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9469578 0.792 rs79297236 chr6:33713930 T/C cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs765787 0.530 rs4775831 chr15:45534722 A/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.7 -0.43 1.5e-16 Uric acid levels; LUSC cis rs1891275 0.509 rs76313529 chr10:93443076 T/C cg07889827 chr10:93443413 NA -0.38 -8.35 -0.42 1.86e-15 Intelligence (multi-trait analysis); LUSC cis rs6977660 0.714 rs10224920 chr7:19816173 A/T cg07541023 chr7:19748670 TWISTNB 0.62 6.77 0.35 5.83e-11 Thyroid stimulating hormone; LUSC trans rs2587949 0.571 rs2587916 chr3:4185379 T/C cg15139668 chr4:4577005 NA -0.43 -5.96 -0.31 6.24e-9 Periodontitis (DPAL); LUSC cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg13256891 chr4:100009986 ADH5 0.51 6.96 0.36 1.79e-11 Smoking initiation; LUSC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.88 -0.31 9.73e-9 Extrinsic epigenetic age acceleration; LUSC cis rs12893668 0.697 rs67899457 chr14:104060066 A/T cg08213375 chr14:104286397 PPP1R13B 0.37 6.42 0.33 4.76e-10 Reticulocyte count; LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6574644 1.000 rs6574639 chr14:81771541 C/T cg01989461 chr14:81687754 GTF2A1 0.47 5.66 0.3 3.21e-8 Obesity-related traits; LUSC cis rs10791097 0.547 rs11222371 chr11:130745719 C/T cg12179176 chr11:130786555 SNX19 0.83 14.41 0.62 6.14e-37 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs754133 0.964 rs894738 chr12:54417525 C/T cg10005224 chr12:54424964 HOXC4;HOXC5 0.39 7.69 0.39 1.68e-13 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs9311676 0.656 rs11708895 chr3:58403042 T/C cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.3e-10 Systemic lupus erythematosus; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14293776 chr19:12371199 NA -0.48 -6.43 -0.33 4.34e-10 Bipolar disorder and schizophrenia; LUSC cis rs559928 0.606 rs11231710 chr11:63925743 A/G cg24687543 chr11:63912206 MACROD1 0.48 5.84 0.3 1.26e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg16447950 chr5:562315 NA -0.52 -6.88 -0.35 3e-11 Obesity-related traits; LUSC cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg24642439 chr20:33292090 TP53INP2 0.5 7.45 0.38 8.24e-13 Height; LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg12432903 chr7:1882776 MAD1L1 -0.5 -8.46 -0.42 8.76e-16 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg06740227 chr12:86229804 RASSF9 0.39 6.1 0.32 2.98e-9 Major depressive disorder; LUSC cis rs7614311 0.636 rs73117057 chr3:63915689 A/G cg22134162 chr3:63841271 THOC7 -0.49 -6.1 -0.32 3.02e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs908922 0.676 rs7547628 chr1:152527738 T/C cg20991723 chr1:152506922 NA 0.48 8.93 0.44 2.85e-17 Hair morphology; LUSC cis rs113835537 0.529 rs11227501 chr11:66274072 T/C cg24851651 chr11:66362959 CCS 0.53 8.02 0.4 1.8e-14 Airway imaging phenotypes; LUSC cis rs6964587 1.000 rs9969198 chr7:91567492 G/T cg22709100 chr7:91322751 NA -0.39 -5.83 -0.3 1.32e-8 Breast cancer; LUSC cis rs11190604 1.000 rs9420785 chr10:102240451 C/G cg16342193 chr10:102329863 NA -0.34 -6.16 -0.32 2.12e-9 Palmitoleic acid (16:1n-7) levels; LUSC trans rs1941687 0.563 rs7238931 chr18:31334993 G/A cg27147174 chr7:100797783 AP1S1 -0.56 -8.87 -0.44 4.36e-17 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs8141529 0.871 rs5762877 chr22:29277555 G/A cg02153584 chr22:29168773 CCDC117 0.62 8.6 0.43 3.07e-16 Lymphocyte counts; LUSC trans rs4724055 0.793 rs473147 chr7:41606407 G/T cg23476065 chr7:151106043 WDR86 0.72 6.22 0.32 1.51e-9 Non-substance related behavioral disinhibition; LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg04944784 chr2:26401820 FAM59B 0.65 8.86 0.44 4.89e-17 Gut microbiome composition (summer); LUSC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg01097406 chr16:89675127 NA -0.34 -6.78 -0.35 5.4e-11 Vitiligo; LUSC cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs6546537 0.550 rs72837959 chr2:69780762 C/T cg10773587 chr2:69614142 GFPT1 -0.42 -6.66 -0.34 1.14e-10 Serum thyroid-stimulating hormone levels; LUSC cis rs559928 0.947 rs56339474 chr11:64142478 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 6.77 0.35 5.96e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs12893668 0.644 rs12890820 chr14:104034849 T/C cg04998671 chr14:104000505 TRMT61A -0.46 -6.47 -0.33 3.39e-10 Reticulocyte count; LUSC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.24 0.52 4.45e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg23711669 chr6:146136114 FBXO30 0.9 17.22 0.69 5.08e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.35 6.53 0.34 2.4e-10 Monocyte percentage of white cells; LUSC cis rs7824557 0.707 rs3808518 chr8:11143272 A/C cg21775007 chr8:11205619 TDH -0.72 -11.95 -0.55 1.22e-27 Retinal vascular caliber; LUSC cis rs4974559 0.739 rs28429103 chr4:1320023 G/A cg02980000 chr4:1222292 CTBP1 1.04 9.63 0.47 1.54e-19 Systolic blood pressure; LUSC cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg13010199 chr12:38710504 ALG10B 0.7 11.58 0.54 2.64e-26 Heart rate; LUSC cis rs3770081 1.000 rs12620810 chr2:86391481 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -1.04 -7.32 -0.37 1.86e-12 Facial emotion recognition (sad faces); LUSC cis rs1044826 1.000 rs1586863 chr3:139138242 C/G cg00490450 chr3:139108681 COPB2 0.55 7.32 0.37 1.82e-12 Obesity-related traits; LUSC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg04998671 chr14:104000505 TRMT61A -0.42 -5.94 -0.31 7.19e-9 Reticulocyte count; LUSC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -15.74 -0.65 3.87e-42 Prostate cancer; LUSC cis rs2979489 1.000 rs2979469 chr8:30285091 C/G cg26383811 chr8:30366931 RBPMS 0.43 6.49 0.33 3.09e-10 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs858239 0.570 rs10271613 chr7:23162586 G/A cg23682824 chr7:23144976 KLHL7 0.38 5.67 0.3 3.03e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.44e-8 Intelligence (multi-trait analysis); LUSC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg11764359 chr7:65958608 NA 0.52 6.85 0.35 3.5e-11 Aortic root size; LUSC cis rs3806843 1.000 rs1548701 chr5:140164557 T/C cg26395211 chr5:140044315 WDR55 -0.37 -5.78 -0.3 1.74e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs79911532 0.515 rs113229120 chr7:75748581 C/T cg03592824 chr7:75666768 STYXL1 0.67 6.39 0.33 5.7e-10 Mononucleosis; LUSC cis rs4891159 0.548 rs609487 chr18:74134382 C/G cg24786174 chr18:74118243 ZNF516 -0.94 -21.04 -0.76 3.45e-63 Longevity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00394725 chr7:75024729 TRIM74;TRIM73 0.38 6.23 0.32 1.42e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg22920501 chr2:26401640 FAM59B -0.82 -12.46 -0.56 1.59e-29 Gut microbiome composition (summer); LUSC trans rs61931739 0.890 rs1849160 chr12:34140191 A/G cg26384229 chr12:38710491 ALG10B 0.56 8.85 0.44 5.37e-17 Morning vs. evening chronotype; LUSC cis rs9916302 0.706 rs7212621 chr17:37527911 T/G cg07936489 chr17:37558343 FBXL20 0.8 9.85 0.47 2.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs11098499 0.820 rs12503082 chr4:120284317 A/G cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs7215564 0.908 rs34547024 chr17:78661373 C/G cg09596252 chr17:78655493 RPTOR 0.54 5.94 0.31 7.02e-9 Myopia (pathological); LUSC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.0 0.36 1.39e-11 Colonoscopy-negative controls vs population controls; LUSC trans rs877282 1.000 rs11253370 chr10:773712 G/A cg22713356 chr15:30763199 NA 1.07 15.31 0.64 1.78e-40 Uric acid levels; LUSC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg24642439 chr20:33292090 TP53INP2 0.57 8.56 0.42 4.23e-16 Coronary artery disease; LUSC cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg26395211 chr5:140044315 WDR55 0.45 6.93 0.35 2.14e-11 Depressive symptoms (multi-trait analysis); LUSC trans rs4363385 0.626 rs6664183 chr1:153064002 A/G cg17486066 chr1:34330045 HMGB4;CSMD2 0.29 5.95 0.31 6.92e-9 Inflammatory skin disease; LUSC cis rs6087990 0.871 rs1007122 chr20:31346001 C/T cg13636640 chr20:31349939 DNMT3B 0.95 19.5 0.73 4.47e-57 Ulcerative colitis; LUSC cis rs2073300 0.609 rs17757228 chr20:23351288 A/T cg12062639 chr20:23401060 NAPB 0.97 7.93 0.4 3.23e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg12432903 chr7:1882776 MAD1L1 0.53 6.7 0.34 9.1e-11 Bipolar disorder; LUSC cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.38 6.16 0.32 2.05e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg13535736 chr9:111863775 C9orf5 -0.39 -6.41 -0.33 4.93e-10 Menarche (age at onset); LUSC trans rs72674100 1.000 rs28572591 chr4:97986135 G/A cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26981251 chr19:59055609 TRIM28 -0.41 -6.06 -0.31 3.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9790314 0.846 rs12495310 chr3:160970956 T/A cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 4.11e-20 Morning vs. evening chronotype; LUSC cis rs8062405 1.000 rs62037369 chr16:28883841 C/T cg09754948 chr16:28834200 ATXN2L 0.41 5.86 0.31 1.13e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg05340658 chr4:99064831 C4orf37 0.65 10.98 0.52 3.69e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs12048904 0.964 rs3188491 chr1:101338482 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 8.07 0.4 1.3e-14 Multiple sclerosis; LUSC cis rs7827545 1.000 rs7008158 chr8:135565982 T/C cg17885191 chr8:135476712 NA 0.56 8.35 0.42 1.87e-15 Hypertension (SNP x SNP interaction); LUSC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg11742103 chr11:62369870 EML3;MTA2 0.52 8.63 0.43 2.51e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg24397884 chr7:158709396 WDR60 -0.73 -11.79 -0.54 4.7e-27 Height; LUSC cis rs3741798 1.000 rs61922054 chr12:12499472 A/G cg08615371 chr12:12503544 MANSC1 1.09 11.16 0.52 8.68e-25 Cerebrospinal fluid biomarker levels; LUSC cis rs9326248 0.581 rs10892063 chr11:116896155 A/C cg20608306 chr11:116969690 SIK3 0.37 6.97 0.36 1.73e-11 Blood protein levels; LUSC cis rs11190604 0.767 rs11190531 chr10:102187310 T/A cg07080220 chr10:102295463 HIF1AN 0.59 7.86 0.4 5.23e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3858526 0.834 rs7125255 chr11:5980384 T/A cg02574844 chr11:5959923 NA -0.45 -6.22 -0.32 1.51e-9 DNA methylation (variation); LUSC trans rs561341 1.000 rs55643307 chr17:30263074 T/C cg20587970 chr11:113659929 NA -1.3 -16.35 -0.67 1.49e-44 Hip circumference adjusted for BMI; LUSC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg18451016 chr1:38461880 NA -0.48 -6.91 -0.35 2.47e-11 Coronary artery disease; LUSC cis rs9467773 0.967 rs6941022 chr6:26553531 T/C cg11502198 chr6:26597334 ABT1 0.62 9.85 0.47 2.95e-20 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs2204008 0.774 rs9669565 chr12:38294428 C/A cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Bladder cancer; LUSC cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg01256987 chr12:42539512 GXYLT1 -0.46 -8.51 -0.42 5.88e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg14668632 chr7:2872130 GNA12 -0.45 -6.68 -0.34 9.86e-11 Height; LUSC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg03605463 chr16:89740564 NA 0.6 9.41 0.46 8.23e-19 Vitiligo; LUSC cis rs12541635 0.966 rs2059943 chr8:107071607 G/T cg10147462 chr8:107024639 NA 0.53 9.59 0.46 2.12e-19 Age of smoking initiation; LUSC cis rs1535500 0.967 rs11756070 chr6:39282748 G/A cg06347083 chr6:39282316 KCNK17 -0.29 -6.27 -0.32 1.14e-9 Type 2 diabetes; LUSC cis rs12421382 0.576 rs116158609 chr11:109389358 T/A cg16359550 chr11:109292809 C11orf87 0.34 5.99 0.31 5.43e-9 Schizophrenia; LUSC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg06850241 chr22:41845214 NA 0.35 6.29 0.33 9.8e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.72 0.39 1.36e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs500891 0.553 rs1112483 chr6:84112033 G/A cg08257003 chr6:84140564 ME1 0.34 7.6 0.38 3.06e-13 Platelet-derived growth factor BB levels; LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03352830 chr11:487213 PTDSS2 0.71 8.55 0.42 4.65e-16 Body mass index; LUSC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.51 6.81 0.35 4.54e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs2625529 0.652 rs7497104 chr15:72154000 C/T cg16672083 chr15:72433130 SENP8 -0.48 -8.11 -0.41 9.49e-15 Red blood cell count; LUSC cis rs2262909 0.962 rs4932952 chr19:22246788 G/A cg11619707 chr19:22235551 ZNF257 0.39 5.83 0.3 1.29e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6496044 0.611 rs8026938 chr15:86069118 G/T cg13263323 chr15:86062960 AKAP13 0.37 5.96 0.31 6.44e-9 Interstitial lung disease; LUSC cis rs1790761 0.505 rs7941395 chr11:67347417 A/G cg24690094 chr11:67383802 NA -0.3 -5.71 -0.3 2.46e-8 Mean corpuscular volume; LUSC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg09835421 chr16:68378352 PRMT7 -0.56 -6.31 -0.33 8.67e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs10905065 0.862 rs9423948 chr10:5742491 G/A cg11519256 chr10:5708881 ASB13 0.41 6.03 0.31 4.26e-9 Menopause (age at onset); LUSC cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg03517284 chr6:25882590 NA -0.52 -9.88 -0.48 2.37e-20 Blood metabolite levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00323305 chr3:24537182 THRB 0.7 5.99 0.31 5.55e-9 Cognitive performance; LUSC cis rs10208940 0.920 rs6742045 chr2:68811850 G/A cg12452813 chr2:68675892 NA 0.59 6.08 0.32 3.21e-9 Urate levels in lean individuals; LUSC cis rs3125734 0.633 rs3765002 chr10:64006124 G/T cg19640130 chr10:64028056 RTKN2 -0.4 -7.1 -0.36 7.61e-12 Rheumatoid arthritis; LUSC cis rs11168351 0.517 rs10875754 chr12:48557922 G/C cg21466736 chr12:48725269 NA -0.29 -5.84 -0.3 1.21e-8 Bipolar disorder and schizophrenia; LUSC cis rs4589502 0.614 rs17273637 chr15:67193084 C/T cg09911534 chr15:67153556 NA -0.59 -5.73 -0.3 2.21e-8 Lung cancer (smoking interaction); LUSC cis rs7267979 0.586 rs6050432 chr20:25184028 T/C cg08601574 chr20:25228251 PYGB 0.44 6.68 0.34 1e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4911259 0.552 rs2014837 chr20:31461082 C/T cg13636640 chr20:31349939 DNMT3B 0.78 14.96 0.63 4.23e-39 Inflammatory bowel disease; LUSC cis rs4363385 0.693 rs6656812 chr1:152930254 C/T cg07796016 chr1:152779584 LCE1C 0.42 6.08 0.32 3.3e-9 Inflammatory skin disease; LUSC cis rs1395 0.778 rs34618115 chr2:27418289 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.27 0.37 2.64e-12 Blood metabolite levels; LUSC cis rs7772486 0.875 rs1412080 chr6:146417304 T/C cg23711669 chr6:146136114 FBXO30 0.83 14.52 0.62 2.22e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg00071950 chr4:10020882 SLC2A9 0.6 10.32 0.49 7.29e-22 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7208859 0.573 rs11656278 chr17:29075188 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2439831 0.850 rs60883262 chr15:44076503 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.86 8.84 0.44 5.53e-17 Lung cancer in ever smokers; LUSC cis rs3008870 0.677 rs2815354 chr1:67483642 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.94 13.53 0.59 1.49e-33 Lymphocyte percentage of white cells; LUSC cis rs4730250 0.707 rs80095766 chr7:106901394 G/T cg02696742 chr7:106810147 HBP1 -0.63 -9.64 -0.47 1.45e-19 Osteoarthritis; LUSC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.91 -0.35 2.41e-11 Coronary artery disease; LUSC cis rs859767 0.501 rs1568120 chr2:135406890 A/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Neuroticism; LUSC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg23262073 chr20:60523788 NA -0.42 -6.07 -0.32 3.45e-9 Body mass index; LUSC trans rs7824557 0.564 rs2736300 chr8:11235579 T/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.53 -0.38 4.91e-13 Retinal vascular caliber; LUSC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg19729930 chr2:74357872 NA 0.88 15.29 0.64 2.2e-40 Gestational age at birth (maternal effect); LUSC cis rs1712517 0.744 rs4293063 chr10:105052976 G/T cg05636881 chr10:105038444 INA 0.39 6.32 0.33 8.31e-10 Migraine; LUSC cis rs11758351 1.000 rs1341759 chr6:26195502 G/A cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs7584330 0.518 rs11884238 chr2:238424671 T/G cg16989719 chr2:238392110 NA -0.4 -5.84 -0.3 1.27e-8 Prostate cancer; LUSC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.56 0.34 2.05e-10 Schizophrenia; LUSC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg18876405 chr7:65276391 NA 0.76 13.71 0.6 3.13e-34 Calcium levels; LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg08219700 chr8:58056026 NA 0.64 8.19 0.41 5.6e-15 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.576 rs7513645 chr1:205698026 A/G cg26354017 chr1:205819088 PM20D1 0.43 5.75 0.3 2.02e-8 Menarche (age at onset); LUSC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg07701084 chr6:150067640 NUP43 0.57 8.69 0.43 1.6e-16 Lung cancer; LUSC trans rs1005277 0.522 rs1208684 chr10:38093936 G/A cg17830980 chr10:43048298 ZNF37B -0.41 -6.56 -0.34 2.01e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9361491 0.508 rs7773448 chr6:79417356 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.66 -0.3 3.34e-8 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg15445000 chr17:37608096 MED1 -0.39 -6.75 -0.35 6.68e-11 Glomerular filtration rate (creatinine); LUSC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11644478 chr21:40555479 PSMG1 -0.65 -10.25 -0.49 1.28e-21 Menarche (age at onset); LUSC cis rs11864453 0.826 rs2074627 chr16:72136769 C/T cg16558253 chr16:72132732 DHX38 -0.41 -6.32 -0.33 8.5e-10 Fibrinogen levels; LUSC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg06454157 chr6:167490870 NA -0.25 -5.96 -0.31 6.44e-9 Crohn's disease; LUSC trans rs1922233 0.843 rs6854368 chr4:92365952 T/A cg24250684 chr1:219729030 NA -0.32 -6.0 -0.31 5.17e-9 Gut microbiome composition (summer and winter); LUSC cis rs12618769 0.597 rs17033136 chr2:99149404 C/T cg10123293 chr2:99228465 UNC50 -0.46 -7.65 -0.39 2.1e-13 Bipolar disorder; LUSC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg04267008 chr7:1944627 MAD1L1 0.42 6.15 0.32 2.27e-9 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg15445000 chr17:37608096 MED1 -0.4 -6.44 -0.33 4.04e-10 Glomerular filtration rate (creatinine); LUSC cis rs9359856 0.600 rs1179899 chr6:90320258 C/T cg13799429 chr6:90582589 CASP8AP2 -0.76 -8.17 -0.41 6.36e-15 Bipolar disorder; LUSC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg25319279 chr11:5960081 NA -0.39 -6.01 -0.31 4.83e-9 DNA methylation (variation); LUSC cis rs1595825 0.891 rs7585709 chr2:198883682 C/T cg00982548 chr2:198649783 BOLL -0.54 -6.93 -0.35 2.2e-11 Ulcerative colitis; LUSC cis rs10465746 0.780 rs2147392 chr1:84404154 C/A cg10977910 chr1:84465055 TTLL7 0.45 6.54 0.34 2.29e-10 Obesity-related traits; LUSC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg05425664 chr17:57184151 TRIM37 0.54 8.01 0.4 1.88e-14 Intelligence (multi-trait analysis); LUSC cis rs427941 0.632 rs201480 chr7:101747575 A/G cg06246474 chr7:101738831 CUX1 0.39 6.39 0.33 5.42e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7582720 1.000 rs72932558 chr2:203847325 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.23 -0.37 3.22e-12 Menopause (age at onset); LUSC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg23583168 chr7:148888333 NA -0.82 -13.18 -0.59 3.04e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8044995 0.563 rs3785113 chr16:68369213 T/C cg09835421 chr16:68378352 PRMT7 -0.75 -8.42 -0.42 1.13e-15 Schizophrenia; LUSC cis rs637571 0.584 rs594689 chr11:65635559 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.45 -7.96 -0.4 2.78e-14 Eosinophil percentage of white cells; LUSC cis rs172166 0.560 rs203878 chr6:28048996 T/G cg21251018 chr6:28226885 NKAPL 0.31 5.95 0.31 6.94e-9 Cardiac Troponin-T levels; LUSC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.24 0.52 4.42e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg27074582 chr2:240114406 HDAC4 0.44 7.0 0.36 1.38e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7843479 0.870 rs1809498 chr8:21836384 C/G cg17168535 chr8:21777572 XPO7 -0.59 -8.74 -0.43 1.19e-16 Mean corpuscular volume; LUSC trans rs453301 0.624 rs330049 chr8:9087299 C/T cg08975724 chr8:8085496 FLJ10661 0.42 5.97 0.31 6.03e-9 Joint mobility (Beighton score); LUSC cis rs2777491 1.000 rs7168177 chr15:41715585 A/G cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.53 -0.59 1.51e-33 Ulcerative colitis; LUSC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6429082 0.715 rs2153204 chr1:235580382 A/G cg26050004 chr1:235667680 B3GALNT2 -0.56 -7.95 -0.4 2.89e-14 Adiposity; LUSC cis rs72634258 0.740 rs4489581 chr1:8174495 A/C cg26816564 chr1:7831052 VAMP3 -0.44 -5.76 -0.3 1.96e-8 Inflammatory bowel disease; LUSC cis rs1215050 0.791 rs4699318 chr4:98664370 T/G cg05340658 chr4:99064831 C4orf37 -0.46 -7.27 -0.37 2.5e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.61 -8.44 -0.42 1.01e-15 Mean platelet volume; LUSC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -6.66 -0.34 1.11e-10 Bipolar disorder; LUSC trans rs656319 0.513 rs6985941 chr8:9983179 C/T cg21775007 chr8:11205619 TDH -0.47 -6.44 -0.33 4.19e-10 Myopia (pathological); LUSC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs7819412 0.703 rs2409713 chr8:11009797 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.29 -0.33 1.01e-9 Triglycerides; LUSC cis rs4764124 0.646 rs2075268 chr12:14956476 A/G cg19759883 chr12:14956454 WBP11;C12orf60 0.38 5.86 0.31 1.14e-8 Pubertal anthropometrics; LUSC cis rs10782582 0.593 rs11576534 chr1:76112751 C/T cg22875332 chr1:76189707 ACADM -0.42 -6.49 -0.33 3.14e-10 Daytime sleep phenotypes; LUSC cis rs7575217 0.697 rs6727703 chr2:101698533 G/T cg23907051 chr2:101730305 TBC1D8 0.28 7.61 0.38 2.76e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg12463550 chr7:65579703 CRCP 0.48 6.69 0.34 9.43e-11 Aortic root size; LUSC cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg10253484 chr15:75165896 SCAMP2 0.39 5.67 0.3 3.07e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs28830936 0.934 rs3959569 chr15:42115747 G/C cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.88 -0.31 1.01e-8 Diastolic blood pressure; LUSC cis rs9644630 0.897 rs17128525 chr8:19364006 C/T cg01280390 chr8:19363452 CSGALNACT1 -0.33 -6.42 -0.33 4.65e-10 Oropharynx cancer; LUSC cis rs9814567 1.000 rs9884031 chr3:134256500 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2882667 0.898 rs6863347 chr5:138361135 C/T cg04439458 chr5:138467593 SIL1 -0.39 -7.81 -0.39 7.32e-14 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6696846 0.515 rs10900450 chr1:205106238 C/G cg00857998 chr1:205179979 DSTYK 0.48 6.81 0.35 4.45e-11 Red blood cell count; LUSC cis rs7589342 0.839 rs12995333 chr2:106436366 A/C cg16077055 chr2:106428750 NCK2 -0.37 -7.14 -0.36 5.97e-12 Addiction; LUSC cis rs7819412 0.522 rs10088853 chr8:10987967 G/A cg21775007 chr8:11205619 TDH -0.58 -7.74 -0.39 1.23e-13 Triglycerides; LUSC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.98 0.4 2.38e-14 Parkinson's disease; LUSC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg12311346 chr5:56204834 C5orf35 -1.01 -14.63 -0.62 8.61e-38 Initial pursuit acceleration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11296937 chr11:64084966 PRDX5;TRMT112 -0.5 -6.47 -0.33 3.45e-10 Bipolar disorder and schizophrenia; LUSC cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg17420585 chr12:42539391 GXYLT1 -0.38 -7.44 -0.38 8.78e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg22920501 chr2:26401640 FAM59B 0.82 12.46 0.56 1.59e-29 Gut microbiome composition (summer); LUSC cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.81 0.3 1.43e-8 Cerebrospinal P-tau181p levels; LUSC cis rs6964587 0.869 rs7812219 chr7:91545727 C/T cg17063962 chr7:91808500 NA -0.53 -7.96 -0.4 2.69e-14 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21326301 chr3:180397115 CCDC39 0.41 5.94 0.31 7.05e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC cis rs34375054 0.660 rs12578446 chr12:125605887 A/G cg25124228 chr12:125621409 AACS -0.57 -8.95 -0.44 2.55e-17 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3764021 0.870 rs10844622 chr12:9885082 G/A cg20894963 chr12:9885564 CLECL1 0.34 6.98 0.36 1.64e-11 Type 1 diabetes; LUSC cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg23992470 chr4:843637 GAK 0.53 5.66 0.3 3.22e-8 Intelligence (multi-trait analysis); LUSC cis rs9302635 0.513 rs8044555 chr16:72152755 T/C cg16558253 chr16:72132732 DHX38 -0.41 -5.7 -0.3 2.63e-8 Blood protein levels; LUSC cis rs4920343 0.890 rs4920531 chr1:19095746 A/G cg19637330 chr1:19110922 NA -0.39 -5.76 -0.3 1.95e-8 Knee osteoarthritis; LUSC cis rs6484504 0.779 rs16921914 chr11:31210771 G/A cg06552810 chr11:31128660 NA -0.41 -6.4 -0.33 5.13e-10 Red blood cell count; LUSC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg23985595 chr17:80112537 CCDC57 0.32 6.22 0.32 1.45e-9 Life satisfaction; LUSC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg06808227 chr14:105710500 BRF1 -0.68 -10.44 -0.5 2.91e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg19920283 chr7:105172520 RINT1 0.58 6.11 0.32 2.71e-9 Bipolar disorder (body mass index interaction); LUSC cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg08213375 chr14:104286397 PPP1R13B 0.52 10.4 0.49 3.86e-22 Schizophrenia; LUSC trans rs853679 0.607 rs68188794 chr6:28080777 T/C cg06606381 chr12:133084897 FBRSL1 -1.05 -9.08 -0.44 9.63e-18 Depression; LUSC cis rs722599 0.683 rs7145246 chr14:75242394 A/T cg06637938 chr14:75390232 RPS6KL1 -0.4 -5.69 -0.3 2.84e-8 IgG glycosylation; LUSC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg18402987 chr7:1209562 NA 0.62 7.2 0.37 3.95e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7586879 0.796 rs11684619 chr2:25078859 G/A cg01884057 chr2:25150051 NA 0.39 8.03 0.4 1.63e-14 Body mass index; LUSC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg08219700 chr8:58056026 NA 0.63 7.97 0.4 2.45e-14 Developmental language disorder (linguistic errors); LUSC cis rs6598955 0.543 rs3795687 chr1:26560745 G/A cg04990556 chr1:26633338 UBXN11 0.88 11.64 0.54 1.61e-26 Obesity-related traits; LUSC cis rs7909074 0.766 rs5000415 chr10:45383674 C/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.38 -0.42 1.49e-15 Mean corpuscular volume; LUSC trans rs7618501 0.573 rs2624824 chr3:50088266 T/C cg21659725 chr3:3221576 CRBN -0.64 -10.53 -0.5 1.4e-22 Intelligence (multi-trait analysis); LUSC cis rs6725517 0.737 rs7576788 chr2:25083310 A/G cg15423357 chr2:25149977 NA 0.31 6.02 0.31 4.57e-9 Breast cancer; LUSC cis rs2762353 0.505 rs2096386 chr6:25787817 C/T cg16482183 chr6:26056742 HIST1H1C -0.4 -5.92 -0.31 8.14e-9 Blood metabolite levels; LUSC cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs497273 0.553 rs508595 chr12:121198891 C/G cg02419362 chr12:121203948 SPPL3 0.43 7.9 0.4 4.05e-14 Systemic lupus erythematosus; LUSC cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg25258033 chr6:167368657 RNASET2 0.39 6.3 0.33 9.49e-10 Crohn's disease; LUSC cis rs11676348 0.755 rs13410318 chr2:219022910 T/G cg06547715 chr2:218990976 CXCR2 -0.32 -6.43 -0.33 4.46e-10 Ulcerative colitis; LUSC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg20476274 chr7:133979776 SLC35B4 0.85 15.9 0.66 9.04e-43 Mean platelet volume; LUSC cis rs67460515 0.563 rs35914913 chr3:160826561 A/G cg03342759 chr3:160939853 NMD3 -0.44 -6.04 -0.31 4.06e-9 Parkinson's disease; LUSC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg02187348 chr16:89574699 SPG7 0.49 7.48 0.38 6.67e-13 Multiple myeloma (IgH translocation); LUSC cis rs35146811 0.695 rs858509 chr7:99821470 A/G cg13334819 chr7:99746414 C7orf59 0.5 6.68 0.34 9.99e-11 Coronary artery disease; LUSC cis rs62400317 0.762 rs17423748 chr6:44943982 T/C cg20913747 chr6:44695427 NA -0.46 -7.2 -0.37 3.91e-12 Total body bone mineral density; LUSC cis rs722599 0.748 rs61978948 chr14:75363369 G/A cg06637938 chr14:75390232 RPS6KL1 -0.41 -6.1 -0.32 3e-9 IgG glycosylation; LUSC cis rs9796 0.624 rs9920619 chr15:41318845 A/G cg18705301 chr15:41695430 NDUFAF1 -0.58 -10.38 -0.49 4.68e-22 Menopause (age at onset); LUSC cis rs911119 1.000 rs13041070 chr20:23614261 G/A cg16589663 chr20:23618590 CST3 0.6 7.03 0.36 1.15e-11 Chronic kidney disease; LUSC cis rs9902453 0.817 rs4794861 chr17:28183174 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.64 0.47 1.43e-19 Coffee consumption (cups per day); LUSC cis rs11792861 0.591 rs10979632 chr9:111732140 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.68 11.64 0.54 1.65e-26 Menarche (age at onset); LUSC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2346177 0.519 rs2121698 chr2:46709571 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.6 -9.47 -0.46 5.4e-19 HDL cholesterol; LUSC cis rs9398803 0.865 rs9385400 chr6:126764190 G/T cg19875578 chr6:126661172 C6orf173 -0.39 -5.81 -0.3 1.42e-8 Male-pattern baldness; LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.52 0.46 3.68e-19 Bipolar disorder; LUSC cis rs829883 0.763 rs249843 chr12:98870987 G/A cg25150519 chr12:98850993 NA 0.78 13.62 0.6 6.8e-34 Colorectal adenoma (advanced); LUSC cis rs3008870 0.755 rs2815380 chr1:67510857 A/G cg02640540 chr1:67518911 SLC35D1 -0.5 -7.18 -0.37 4.43e-12 Lymphocyte percentage of white cells; LUSC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg04455712 chr21:45112962 RRP1B 0.45 8.46 0.42 8.61e-16 Mean corpuscular volume; LUSC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC cis rs2637266 0.626 rs724113 chr10:78557309 C/T cg18941641 chr10:78392320 NA 0.38 7.03 0.36 1.19e-11 Pulmonary function; LUSC cis rs727505 0.866 rs67724276 chr7:124719719 G/A cg23710748 chr7:124431027 NA -0.39 -6.89 -0.35 2.79e-11 Lewy body disease; LUSC cis rs7605378 1.000 rs769958 chr2:200695901 G/A cg17644776 chr2:200775616 C2orf69 0.39 6.24 0.32 1.29e-9 Osteoporosis; LUSC cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.55 -8.68 -0.43 1.83e-16 Personality dimensions; LUSC cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg18876405 chr7:65276391 NA 0.5 6.88 0.35 2.93e-11 Corneal structure; LUSC trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.94 -0.36 2.02e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs7264396 0.563 rs2425120 chr20:34324456 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.38 -0.42 1.49e-15 Total cholesterol levels; LUSC cis rs2067615 0.524 rs754184 chr12:107117521 A/G cg15890332 chr12:107067104 RFX4 0.34 6.11 0.32 2.8e-9 Heart rate; LUSC cis rs10979 1.000 rs9376760 chr6:143886969 C/T cg25407410 chr6:143891975 LOC285740 -0.7 -11.21 -0.52 5.61e-25 Hypospadias; LUSC cis rs34172651 0.876 rs2547033 chr16:24743657 C/T cg06028605 chr16:24865363 SLC5A11 0.44 8.01 0.4 1.97e-14 Intelligence (multi-trait analysis); LUSC cis rs11105298 0.891 rs10858900 chr12:89925081 C/A cg00757033 chr12:89920650 WDR51B 0.59 10.4 0.49 3.99e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4589502 0.920 rs77518050 chr15:67138089 T/C cg09911534 chr15:67153556 NA -0.69 -6.93 -0.35 2.15e-11 Lung cancer (smoking interaction); LUSC cis rs113835537 0.529 rs2279864 chr11:66247844 G/A cg24851651 chr11:66362959 CCS 0.54 8.02 0.4 1.77e-14 Airway imaging phenotypes; LUSC cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg01579765 chr21:45077557 HSF2BP -0.51 -10.72 -0.51 3.01e-23 Mean corpuscular volume; LUSC cis rs11209002 0.592 rs7551197 chr1:67588090 A/T cg02640540 chr1:67518911 SLC35D1 0.58 8.16 0.41 7.01e-15 Crohn's disease; LUSC cis rs870825 0.549 rs28579266 chr4:185627262 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs859767 0.501 rs12691869 chr2:135407641 T/C cg12500956 chr2:135428796 TMEM163 -0.27 -6.44 -0.33 4.25e-10 Neuroticism; LUSC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg16606324 chr3:10149918 C3orf24 0.62 9.12 0.45 7.2e-18 Alzheimer's disease; LUSC cis rs4423214 0.592 rs7120029 chr11:71198957 G/A cg05163923 chr11:71159392 DHCR7 -0.7 -7.32 -0.37 1.82e-12 Vitamin D levels; LUSC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs225245 0.755 rs7217565 chr17:34024707 C/A cg05299278 chr17:33885742 SLFN14 0.29 6.44 0.33 4.09e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs8180040 1.000 rs295428 chr3:47359262 G/T cg27129171 chr3:47204927 SETD2 0.72 12.42 0.56 2.16e-29 Colorectal cancer; LUSC trans rs11098499 0.865 rs11722183 chr4:120280597 A/C cg25214090 chr10:38739885 LOC399744 0.52 7.75 0.39 1.15e-13 Corneal astigmatism; LUSC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.61 -6.19 -0.32 1.77e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg04871131 chr7:94954202 PON1 -0.37 -5.89 -0.31 9.34e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs17401966 0.867 rs6696056 chr1:10305992 C/A cg19773385 chr1:10388646 KIF1B -0.53 -9.18 -0.45 4.63e-18 Hepatocellular carcinoma; LUSC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.2 0.41 5.41e-15 Electroencephalogram traits; LUSC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg08677398 chr8:58056175 NA 0.52 6.08 0.32 3.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs1865760 1.000 rs6938233 chr6:25914077 C/T cg16482183 chr6:26056742 HIST1H1C 0.42 6.08 0.32 3.28e-9 Height; LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg15147215 chr3:52552868 STAB1 0.3 5.98 0.31 5.77e-9 Bipolar disorder; LUSC cis rs4363385 0.818 rs10888525 chr1:153000215 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.11 -0.36 7.29e-12 Inflammatory skin disease; LUSC cis rs10170846 0.893 rs11692810 chr2:223544096 A/C cg25565276 chr2:223520875 FARSB -0.58 -8.62 -0.43 2.79e-16 Schizophrenia (inflammation and infection response interaction); LUSC cis rs7712401 0.755 rs27740 chr5:122204772 A/T cg19077854 chr5:122220652 SNX24 -0.35 -8.5 -0.42 6.27e-16 Mean platelet volume; LUSC cis rs2115536 0.692 rs6495450 chr15:80162499 C/A cg02196730 chr15:80188777 MTHFS 0.4 6.03 0.31 4.39e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs367943 0.965 rs458044 chr5:112797779 A/G cg12552261 chr5:112820674 MCC -0.44 -6.96 -0.36 1.77e-11 Type 2 diabetes; LUSC cis rs7973719 0.865 rs1057225 chr12:7363574 C/G cg07052231 chr12:7363540 PEX5 0.52 9.02 0.44 1.53e-17 IgG glycosylation; LUSC trans rs747782 0.639 rs17198985 chr11:48183565 T/C cg15704280 chr7:45808275 SEPT13 0.71 6.66 0.34 1.1e-10 Intraocular pressure; LUSC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg15448220 chr1:150897856 SETDB1 0.38 5.83 0.3 1.28e-8 Melanoma; LUSC cis rs60843830 0.550 rs300751 chr2:209063 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.42 6.66 0.34 1.16e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4654899 0.865 rs10493006 chr1:21375904 G/A cg02927042 chr1:21476669 EIF4G3 -0.4 -6.18 -0.32 1.88e-9 Superior frontal gyrus grey matter volume; LUSC cis rs6591182 0.503 rs11227241 chr11:65389890 G/C cg05805236 chr11:65401703 PCNXL3 -0.48 -7.64 -0.39 2.32e-13 Non-alcoholic fatty liver disease histology (lobular); LUSC cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg23978390 chr7:1156363 C7orf50 0.49 5.68 0.3 2.86e-8 Bronchopulmonary dysplasia; LUSC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg04539111 chr16:67997858 SLC12A4 -0.45 -6.11 -0.32 2.71e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7726839 0.540 rs72703079 chr5:595173 T/C cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.96e-13 Obesity-related traits; LUSC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg03517284 chr6:25882590 NA -0.41 -7.2 -0.37 3.92e-12 Intelligence (multi-trait analysis); LUSC cis rs2242663 0.705 rs551708 chr11:66486143 T/C cg18002602 chr11:66138449 SLC29A2 0.38 6.59 0.34 1.68e-10 Bipolar disorder; LUSC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg24399712 chr22:39784796 NA -0.51 -7.11 -0.36 6.88e-12 IgG glycosylation; LUSC trans rs7939886 0.920 rs11227222 chr11:55876393 G/T cg03929089 chr4:120376271 NA -0.71 -6.09 -0.32 3.18e-9 Myopia (pathological); LUSC cis rs3020736 0.500 rs8138678 chr22:42516229 A/G cg15557168 chr22:42548783 NA 0.46 7.14 0.36 5.78e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg10523679 chr1:76189770 ACADM -0.83 -11.19 -0.52 6.78e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg08048268 chr3:133502702 NA -0.41 -7.41 -0.38 1.07e-12 Iron status biomarkers; LUSC trans rs7286472 0.748 rs13057320 chr22:34365442 C/T cg12297329 chr5:152029980 NA -0.61 -6.32 -0.33 8.56e-10 Blood pressure measurement (cold pressor test); LUSC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg24110177 chr3:50126178 RBM5 -0.61 -10.47 -0.5 2.29e-22 Body mass index; LUSC trans rs6502050 0.835 rs6502067 chr17:80111205 A/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg11764359 chr7:65958608 NA -0.69 -10.7 -0.51 3.53e-23 Aortic root size; LUSC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg13206674 chr6:150067644 NUP43 0.62 9.69 0.47 1.01e-19 Lung cancer; LUSC cis rs60154123 0.730 rs10779528 chr1:210457378 C/T cg22029157 chr1:209979665 IRF6 0.52 5.96 0.31 6.32e-9 Coronary artery disease; LUSC cis rs9487051 0.735 rs351756 chr6:109538773 A/G cg12927641 chr6:109611667 NA 0.35 5.79 0.3 1.61e-8 Reticulocyte fraction of red cells; LUSC cis rs7189233 0.911 rs8057808 chr16:53520613 G/A cg04059762 chr16:53544020 NA -0.34 -6.09 -0.32 3.09e-9 Intelligence (multi-trait analysis); LUSC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11198358 chr17:47928494 NA 0.71 6.25 0.32 1.24e-9 Cognitive performance; LUSC trans rs911555 0.617 rs7156036 chr14:103908142 A/G cg17675199 chr6:35436792 RPL10A -0.4 -5.95 -0.31 6.75e-9 Intelligence (multi-trait analysis); LUSC cis rs9527 0.590 rs3781281 chr10:104852648 A/G cg04362960 chr10:104952993 NT5C2 -0.62 -9.87 -0.48 2.52e-20 Arsenic metabolism; LUSC cis rs7208859 0.623 rs73269923 chr17:29102571 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7786808 0.504 rs10949725 chr7:158196003 C/T cg01191920 chr7:158217561 PTPRN2 0.46 9.26 0.45 2.62e-18 Obesity-related traits; LUSC cis rs9837602 1.000 rs17379739 chr3:99724792 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.96 -0.31 6.33e-9 Breast cancer; LUSC cis rs36093844 0.747 rs17817314 chr11:85594972 T/C cg16165120 chr11:85566439 CCDC83 -0.39 -5.65 -0.3 3.42e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg04944784 chr2:26401820 FAM59B -0.75 -10.88 -0.51 8.22e-24 Gut microbiome composition (summer); LUSC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg06740227 chr12:86229804 RASSF9 -0.41 -6.68 -0.34 1.02e-10 Major depressive disorder; LUSC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg04352962 chr1:209979756 IRF6 0.55 6.37 0.33 6.41e-10 Cleft lip with or without cleft palate; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.11 -0.32 2.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs826838 0.586 rs1843903 chr12:38627524 C/T cg13010199 chr12:38710504 ALG10B 0.54 8.24 0.41 3.83e-15 Heart rate; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08172044 chr6:126070462 HEY2 0.75 6.35 0.33 7.01e-10 Cognitive performance; LUSC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg12560992 chr17:57184187 TRIM37 -0.85 -15.42 -0.64 6.9e-41 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.87 0.44 4.42e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9479482 0.967 rs13209192 chr6:150350099 A/G cg25797454 chr6:150327115 RAET1K 0.32 7.31 0.37 1.99e-12 Alopecia areata; LUSC cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.92 -0.31 8.13e-9 IgG glycosylation; LUSC cis rs7827545 1.000 rs1372660 chr8:135566788 C/G cg17885191 chr8:135476712 NA 0.57 8.55 0.42 4.4e-16 Hypertension (SNP x SNP interaction); LUSC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg13770153 chr20:60521292 NA -0.63 -8.38 -0.42 1.45e-15 Body mass index; LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg16606324 chr3:10149918 C3orf24 0.63 9.16 0.45 5.37e-18 Alzheimer's disease; LUSC cis rs68170813 0.559 rs80212020 chr7:106957596 C/T cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg12463550 chr7:65579703 CRCP -0.44 -6.27 -0.32 1.1e-9 Aortic root size; LUSC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg08270630 chr22:50330655 NA -0.43 -6.39 -0.33 5.55e-10 Schizophrenia; LUSC cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg22709100 chr7:91322751 NA 0.39 5.8 0.3 1.55e-8 Breast cancer; LUSC trans rs12458462 0.892 rs58675823 chr18:77463672 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.8 -0.35 4.92e-11 Monocyte count; LUSC cis rs113835537 0.529 rs11227512 chr11:66281291 T/C cg24851651 chr11:66362959 CCS 0.53 7.93 0.4 3.42e-14 Airway imaging phenotypes; LUSC cis rs733592 0.507 rs7304428 chr12:48494275 T/G cg24011408 chr12:48396354 COL2A1 -0.53 -8.72 -0.43 1.35e-16 Plateletcrit; LUSC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg18305652 chr10:134549665 INPP5A 0.44 6.75 0.35 6.37e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9790314 0.690 rs7617204 chr3:160821969 A/G cg03342759 chr3:160939853 NMD3 -0.41 -6.64 -0.34 1.27e-10 Morning vs. evening chronotype; LUSC cis rs4132509 0.744 rs6687181 chr1:243878518 C/T cg21452805 chr1:244014465 NA 0.63 6.89 0.35 2.74e-11 RR interval (heart rate); LUSC cis rs73198271 0.562 rs75525911 chr8:8659359 C/A cg01851573 chr8:8652454 MFHAS1 0.67 8.93 0.44 2.9e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1355223 0.583 rs1828298 chr11:34870439 A/G cg11058730 chr11:34937778 PDHX;APIP 0.67 10.8 0.51 1.61e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9322817 0.691 rs6907016 chr6:105211360 G/A cg02098413 chr6:105308735 HACE1 -0.28 -5.78 -0.3 1.73e-8 Thyroid stimulating hormone; LUSC cis rs394563 0.967 rs420099 chr6:149794290 A/C cg07828024 chr6:149772892 ZC3H12D -0.32 -6.92 -0.35 2.3e-11 Dupuytren's disease; LUSC cis rs9479482 0.678 rs3903885 chr6:150364128 G/A cg00432049 chr6:150390894 ULBP3 -0.29 -6.38 -0.33 6.07e-10 Alopecia areata; LUSC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg08847533 chr14:75593920 NEK9 -0.78 -13.37 -0.59 5.91e-33 Height; LUSC cis rs4680 1.000 rs165722 chr22:19949013 C/T cg22546130 chr22:19950026 COMT 0.26 5.74 0.3 2.12e-8 Blood metabolite levels; LUSC trans rs11039798 0.614 rs116427493 chr11:48776141 C/T cg03929089 chr4:120376271 NA 0.74 6.91 0.35 2.4e-11 Axial length; LUSC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.44 6.49 0.33 3.06e-10 Systemic lupus erythematosus; LUSC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.2 -0.37 3.9e-12 Bipolar disorder; LUSC cis rs9948 0.655 rs3731940 chr2:97377883 A/G cg01990225 chr2:97406019 LMAN2L 0.75 5.68 0.3 3e-8 Erectile dysfunction and prostate cancer treatment; LUSC cis rs4704187 0.687 rs6885071 chr5:74460045 A/G cg03227963 chr5:74354835 NA 0.32 6.83 0.35 4.02e-11 Response to amphetamines; LUSC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg10755058 chr3:40428713 ENTPD3 0.34 5.73 0.3 2.19e-8 Renal cell carcinoma; LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg08677398 chr8:58056175 NA 0.58 7.01 0.36 1.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg09877947 chr5:131593287 PDLIM4 0.44 6.92 0.35 2.26e-11 Breast cancer; LUSC cis rs1372520 0.623 rs2583975 chr4:90748488 T/C cg15133208 chr4:90757351 SNCA -0.5 -7.44 -0.38 8.32e-13 Neuroticism; LUSC cis rs8060686 0.641 rs7188085 chr16:68113873 A/G cg04539111 chr16:67997858 SLC12A4 -0.43 -5.96 -0.31 6.47e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4363385 0.588 rs1577960 chr1:153025687 G/A cg25856811 chr1:152973957 SPRR3 -0.36 -6.01 -0.31 4.88e-9 Inflammatory skin disease; LUSC cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg00409905 chr10:38381863 ZNF37A -0.36 -6.17 -0.32 1.98e-9 Extrinsic epigenetic age acceleration; LUSC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg19592336 chr6:28129416 ZNF389 0.44 5.75 0.3 2.01e-8 Parkinson's disease; LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg01616529 chr11:638424 DRD4 -0.35 -6.02 -0.31 4.64e-9 Systemic lupus erythematosus; LUSC cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg23711669 chr6:146136114 FBXO30 0.85 15.24 0.64 3.52e-40 Lobe attachment (rater-scored or self-reported); LUSC trans rs62238980 0.614 rs117358438 chr22:32374532 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg10057126 chr4:77819792 ANKRD56 0.48 6.78 0.35 5.45e-11 Emphysema distribution in smoking; LUSC cis rs11785693 0.862 rs11786595 chr8:5001621 T/G cg26367366 chr8:4980734 NA 0.73 8.38 0.42 1.46e-15 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs1461503 0.868 rs10790543 chr11:122838311 A/C cg27398637 chr11:122830231 C11orf63 -0.4 -6.34 -0.33 7.32e-10 Menarche (age at onset); LUSC trans rs7980799 0.682 rs7138529 chr12:33634855 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.27 -0.32 1.12e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs7189233 0.955 rs8044205 chr16:53515093 T/C cg09728985 chr16:53543985 NA -0.34 -6.21 -0.32 1.55e-9 Intelligence (multi-trait analysis); LUSC cis rs1691799 0.867 rs1168309 chr12:66726439 A/G cg16791601 chr12:66731901 HELB 0.69 11.87 0.54 2.4e-27 White blood cell count (basophil); LUSC cis rs9534288 0.830 rs7987953 chr13:46634395 C/T cg15192986 chr13:46630673 CPB2 -0.8 -12.65 -0.57 3.2e-30 Blood protein levels; LUSC cis rs9300255 0.602 rs1727313 chr12:123640853 C/G cg13010344 chr12:123464640 ARL6IP4 -0.46 -5.72 -0.3 2.41e-8 Neutrophil percentage of white cells; LUSC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.18 0.32 1.82e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9640161 0.830 rs1051764 chr7:150070663 T/C cg21361702 chr7:150065534 REPIN1 0.58 9.09 0.45 8.96e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs72781680 0.898 rs113027486 chr2:24098371 G/A cg08917208 chr2:24149416 ATAD2B 0.88 10.0 0.48 9.34e-21 Lymphocyte counts; LUSC cis rs2991971 1.000 rs2993262 chr1:46013733 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.41 -0.33 4.92e-10 High light scatter reticulocyte count; LUSC cis rs2456568 0.548 rs7113080 chr11:93657520 G/A cg26875233 chr11:93583750 C11orf90 -0.3 -5.86 -0.31 1.13e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg20608306 chr11:116969690 SIK3 0.34 6.35 0.33 7.2e-10 Blood protein levels; LUSC cis rs11792861 0.781 rs72607159 chr9:111764270 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.14 0.41 7.71e-15 Menarche (age at onset); LUSC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.05 -0.4 1.43e-14 Neuroticism; LUSC cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg24642439 chr20:33292090 TP53INP2 0.46 7.12 0.36 6.84e-12 Glomerular filtration rate (creatinine); LUSC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg19774624 chr17:42201019 HDAC5 -0.46 -6.69 -0.34 9.28e-11 Total body bone mineral density; LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg02018176 chr4:1364513 KIAA1530 0.46 8.08 0.4 1.17e-14 Obesity-related traits; LUSC cis rs965469 0.779 rs6051683 chr20:3237822 G/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.68 -0.3 2.88e-8 IFN-related cytopenia; LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8.19e-17 Bipolar disorder; LUSC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg26061582 chr7:22766209 IL6 0.48 6.98 0.36 1.56e-11 Lung cancer; LUSC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg03264133 chr6:25882463 NA -0.59 -9.68 -0.47 1.05e-19 Intelligence (multi-trait analysis); LUSC trans rs853679 0.607 rs13216117 chr6:27938484 A/G cg06606381 chr12:133084897 FBRSL1 -0.95 -8.54 -0.42 4.88e-16 Depression; LUSC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg02549819 chr16:58548995 SETD6 0.96 9.0 0.44 1.74e-17 Schizophrenia; LUSC cis rs11030122 0.632 rs4910596 chr11:4084604 A/G cg08557956 chr11:4115526 RRM1 -0.46 -6.02 -0.31 4.66e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg19592336 chr6:28129416 ZNF389 0.47 6.19 0.32 1.75e-9 Depression; LUSC trans rs1814175 0.645 rs28445479 chr11:50047999 A/G cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg18876405 chr7:65276391 NA 0.52 7.81 0.39 7.33e-14 Aortic root size; LUSC trans rs6828577 0.732 rs34983100 chr4:119454442 C/T cg26518628 chr1:97050305 NA -0.54 -7.85 -0.39 5.73e-14 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg21724239 chr8:58056113 NA 0.76 8.32 0.41 2.31e-15 Developmental language disorder (linguistic errors); LUSC cis rs754466 0.651 rs11002322 chr10:79649653 G/T cg17075019 chr10:79541650 NA -0.74 -11.73 -0.54 7.4e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg05425664 chr17:57184151 TRIM37 -0.55 -8.14 -0.41 8.19e-15 Intelligence (multi-trait analysis); LUSC cis rs3857536 0.813 rs6455084 chr6:66935658 A/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs7223966 1.000 rs8081612 chr17:61724695 A/G cg05941027 chr17:61774174 LIMD2 -0.22 -5.9 -0.31 8.69e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs974417 0.529 rs7771745 chr6:97345233 G/A cg10979063 chr6:97285822 GPR63 0.41 6.67 0.34 1.04e-10 Body mass index; LUSC cis rs8017423 0.967 rs4904658 chr14:90721640 C/T cg04374321 chr14:90722782 PSMC1 0.75 12.12 0.55 2.92e-28 Mortality in heart failure; LUSC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.2 -0.37 3.93e-12 Menopause (age at onset); LUSC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.67 11.67 0.54 1.26e-26 Prudent dietary pattern; LUSC trans rs9951602 0.512 rs9949512 chr18:76641845 T/C cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs11098499 0.863 rs10018280 chr4:120478139 T/G cg24375607 chr4:120327624 NA 0.74 10.89 0.51 7.53e-24 Corneal astigmatism; LUSC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg17971929 chr21:40555470 PSMG1 0.78 13.51 0.59 1.8e-33 Cognitive function; LUSC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg08270630 chr22:50330655 NA -0.43 -6.43 -0.33 4.45e-10 Schizophrenia; LUSC cis rs12980942 0.810 rs35812313 chr19:41789178 T/C cg25627403 chr19:41769009 HNRNPUL1 0.59 6.44 0.33 4.28e-10 Coronary artery disease; LUSC cis rs3768617 0.565 rs3768626 chr1:183078462 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.83 0.51 1.26e-23 Fuchs's corneal dystrophy; LUSC cis rs7241530 0.662 rs4799009 chr18:75910320 C/G cg14642773 chr18:75888474 NA 0.39 5.76 0.3 1.92e-8 Educational attainment (years of education); LUSC cis rs7681440 0.583 rs2737023 chr4:90739505 T/C cg06632027 chr4:90757378 SNCA -0.36 -5.69 -0.3 2.71e-8 Dementia with Lewy bodies; LUSC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg17911788 chr17:44343683 NA -0.31 -6.06 -0.31 3.64e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs9329221 0.736 rs12548025 chr8:10260921 A/T cg06636001 chr8:8085503 FLJ10661 0.49 6.63 0.34 1.35e-10 Neuroticism; LUSC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg08048268 chr3:133502702 NA 0.43 8.34 0.42 1.98e-15 Iron status biomarkers; LUSC cis rs950169 0.580 rs11635597 chr15:85165699 C/T cg12863693 chr15:85201151 NMB 0.39 8.23 0.41 4.23e-15 Schizophrenia; LUSC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.72 -0.35 7.71e-11 Blood protein levels; LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg09877947 chr5:131593287 PDLIM4 0.5 7.86 0.4 5.37e-14 Acylcarnitine levels; LUSC cis rs68170813 0.559 rs1121312 chr7:106927820 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.8 -0.47 4.33e-20 Coronary artery disease; LUSC cis rs356992 0.874 rs168565 chr2:60744331 A/G cg08426369 chr2:60753602 BCL11A 0.43 5.88 0.31 9.91e-9 Educational attainment (years of education); LUSC trans rs57221529 0.766 rs4081847 chr5:574072 C/T cg11887960 chr12:57824829 NA 0.54 6.79 0.35 5.04e-11 Lung disease severity in cystic fibrosis; LUSC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.37e-34 Diabetic kidney disease; LUSC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.84 -0.35 3.9e-11 Intelligence (multi-trait analysis); LUSC cis rs17253792 0.822 rs112238223 chr14:56056144 C/A cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs11048434 0.666 rs12371786 chr12:9090086 G/A cg13575925 chr12:9217583 LOC144571 0.33 6.09 0.32 3.14e-9 Sjögren's syndrome; LUSC cis rs4474465 0.850 rs10751294 chr11:78253303 T/A cg27205649 chr11:78285834 NARS2 0.53 6.46 0.33 3.72e-10 Alzheimer's disease (survival time); LUSC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.78 -0.3 1.7e-8 Lung cancer; LUSC cis rs12928939 0.769 rs34680964 chr16:71658594 G/A cg03805757 chr16:71968109 PKD1L3 -0.41 -5.84 -0.3 1.22e-8 Post bronchodilator FEV1; LUSC cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg03146154 chr1:46216737 IPP -0.51 -7.59 -0.38 3.28e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9581857 0.547 rs9581868 chr13:28070682 C/T cg22138327 chr13:27999177 GTF3A 0.8 8.21 0.41 4.85e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg15103426 chr22:29168792 CCDC117 0.45 5.89 0.31 9.3e-9 Lymphocyte counts; LUSC cis rs874628 0.686 rs72999447 chr19:18236947 G/A cg00493341 chr19:18228948 MAST3 0.45 6.04 0.31 4.01e-9 Multiple sclerosis; LUSC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 14.86 0.63 1.07e-38 Platelet count; LUSC cis rs13082711 0.554 rs9310843 chr3:27371260 A/G cg02860705 chr3:27208620 NA 0.51 9.05 0.44 1.23e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs5769707 0.935 rs9616332 chr22:50047678 C/G cg01652190 chr22:50026171 C22orf34 -0.31 -6.32 -0.33 8.42e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs62344088 1.000 rs7715867 chr5:129059 C/T cg22857025 chr5:266934 NA -0.99 -7.1 -0.36 7.53e-12 Asthma (childhood onset); LUSC trans rs877282 0.945 rs11253390 chr10:788678 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg13535736 chr9:111863775 C9orf5 -0.41 -6.87 -0.35 3.23e-11 Menarche (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12028816 chr17:7232827 NEURL4 0.77 6.05 0.31 3.89e-9 Cognitive performance; LUSC cis rs5753618 0.561 rs5753543 chr22:31685458 G/A cg22777020 chr22:31556080 RNF185 -0.44 -5.66 -0.3 3.24e-8 Colorectal cancer; LUSC cis rs11864453 0.612 rs12708925 chr16:72122706 A/T cg01557791 chr16:72042693 DHODH -0.46 -6.84 -0.35 3.89e-11 Fibrinogen levels; LUSC cis rs2281845 0.560 rs12079819 chr1:201085420 G/A cg22815214 chr1:201083145 CACNA1S 0.47 7.01 0.36 1.33e-11 Permanent tooth development; LUSC cis rs2797160 1.000 rs1578794 chr6:126015469 T/C cg05901451 chr6:126070800 HEY2 0.57 8.64 0.43 2.36e-16 Endometrial cancer; LUSC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg20891283 chr12:69753455 YEATS4 0.81 14.87 0.63 1.01e-38 Blood protein levels; LUSC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg06636001 chr8:8085503 FLJ10661 -0.59 -9.17 -0.45 5.15e-18 Mood instability; LUSC cis rs7572644 0.699 rs1458398 chr2:28219941 A/G cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs12310956 0.532 rs2087270 chr12:33850109 C/T cg26384229 chr12:38710491 ALG10B 0.49 7.21 0.37 3.76e-12 Morning vs. evening chronotype; LUSC cis rs16910800 0.731 rs16910754 chr11:23192015 A/G cg20040320 chr11:23191996 NA 0.62 7.77 0.39 1.01e-13 Cancer; LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg03806693 chr22:41940476 POLR3H 0.94 13.86 0.6 8.14e-35 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7824557 0.734 rs2293856 chr8:11177447 C/T cg21775007 chr8:11205619 TDH 0.76 12.43 0.56 2.05e-29 Retinal vascular caliber; LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.06 0.31 3.68e-9 Menopause (age at onset); LUSC cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC trans rs1223397 0.938 rs13205692 chr6:13291560 C/T cg13974761 chr1:152670598 LCE2A 0.37 6.07 0.32 3.51e-9 Blood pressure; LUSC cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.92 -0.44 3.24e-17 Monocyte percentage of white cells; LUSC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg19077165 chr18:44547161 KATNAL2 -0.46 -6.82 -0.35 4.19e-11 Personality dimensions; LUSC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.52 -7.67 -0.39 1.94e-13 Total body bone mineral density; LUSC cis rs6076065 0.548 rs1112819 chr20:23323987 A/G cg11657817 chr20:23433608 CST11 0.5 9.92 0.48 1.75e-20 Facial morphology (factor 15, philtrum width); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14094063 chr7:140624470 BRAF 0.45 6.8 0.35 4.76e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg11266682 chr4:10021025 SLC2A9 0.58 10.7 0.51 3.69e-23 Bone mineral density; LUSC cis rs4906332 1.000 rs3783397 chr14:103947289 A/G cg04998671 chr14:104000505 TRMT61A -0.43 -6.63 -0.34 1.33e-10 Coronary artery disease; LUSC cis rs7103648 0.897 rs3758675 chr11:47400602 G/A cg20307385 chr11:47447363 PSMC3 0.91 15.85 0.66 1.46e-42 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg21427119 chr20:30132790 HM13 -0.36 -5.67 -0.3 3.14e-8 Mean corpuscular hemoglobin; LUSC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.77 -11.97 -0.55 1.05e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg09165964 chr15:75287851 SCAMP5 -1.16 -19.7 -0.73 7.33e-58 Blood trace element (Zn levels); LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg10523679 chr1:76189770 ACADM -0.87 -11.77 -0.54 5.62e-27 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs67539049 1.000 rs73207500 chr8:11293502 T/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.4 -6.13 -0.32 2.51e-9 Itch intensity from mosquito bite; LUSC cis rs8141529 0.732 rs2269577 chr22:29196757 G/C cg02153584 chr22:29168773 CCDC117 0.65 10.49 0.5 1.89e-22 Lymphocyte counts; LUSC cis rs727505 0.954 rs59283092 chr7:124678282 T/C cg23710748 chr7:124431027 NA -0.38 -6.79 -0.35 5.21e-11 Lewy body disease; LUSC cis rs1957429 0.520 rs230718 chr14:65318943 A/G cg23373153 chr14:65346875 NA -0.81 -7.4 -0.38 1.15e-12 Pediatric areal bone mineral density (radius); LUSC cis rs6693567 0.565 rs12739706 chr1:150261653 C/G cg15654264 chr1:150340011 RPRD2 -0.45 -7.29 -0.37 2.25e-12 Migraine; LUSC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.87 0.35 3.2e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg01802117 chr1:53393560 SCP2 -0.37 -6.02 -0.31 4.52e-9 Monocyte count; LUSC cis rs16857609 0.628 rs1478585 chr2:218334784 C/T cg03013118 chr2:218375971 DIRC3 -0.29 -5.7 -0.3 2.6e-8 Breast cancer;Breast cancer (estrogen-receptor negative); LUSC cis rs17162190 0.698 rs12094989 chr1:26848386 A/G cg17456097 chr1:26900765 RPS6KA1 -0.42 -6.02 -0.31 4.71e-9 Mean corpuscular volume; LUSC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.75 0.39 1.14e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs116095464 1.000 rs28416084 chr5:217640 G/A cg22496380 chr5:211416 CCDC127 -0.81 -8.54 -0.42 4.82e-16 Breast cancer; LUSC cis rs7216064 1.000 rs62084214 chr17:65843325 C/G cg12091567 chr17:66097778 LOC651250 -0.75 -9.35 -0.46 1.27e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2816062 0.813 rs2816053 chr1:18895819 A/G cg18795169 chr1:18902165 NA -1.02 -24.92 -0.81 3.39e-78 Urate levels in lean individuals; LUSC cis rs11098499 0.954 rs11729521 chr4:120416788 T/C cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.52e-9 Menopause (age at onset); LUSC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg16339924 chr4:17578868 LAP3 0.59 9.06 0.44 1.15e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4443100 0.792 rs9612223 chr22:23389142 T/G cg14186256 chr22:23484241 RTDR1 0.52 6.43 0.33 4.44e-10 Serum parathyroid hormone levels; LUSC cis rs11098499 0.562 rs2389879 chr4:120557684 G/A cg24375607 chr4:120327624 NA -0.63 -10.05 -0.48 6.3e-21 Corneal astigmatism; LUSC trans rs8072100 0.807 rs2175290 chr17:45479917 C/A cg03886242 chr7:26192032 NFE2L3 -0.39 -6.37 -0.33 6.38e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg04287289 chr16:89883240 FANCA -0.42 -6.18 -0.32 1.82e-9 Vitiligo; LUSC cis rs11190604 1.000 rs2495747 chr10:102328247 C/T cg07080220 chr10:102295463 HIF1AN 0.67 9.04 0.44 1.3e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs5771242 0.776 rs6010198 chr22:50610628 A/G cg16473166 chr22:50639996 SELO -0.59 -7.89 -0.4 4.27e-14 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); LUSC cis rs6987853 0.931 rs3099936 chr8:42384331 C/T cg09913449 chr8:42400586 C8orf40 -0.5 -8.38 -0.42 1.47e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs9287719 0.967 rs10167129 chr2:10758575 G/A cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg06634786 chr22:41940651 POLR3H -0.55 -6.46 -0.33 3.75e-10 Vitiligo; LUSC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg03806693 chr22:41940476 POLR3H -1.05 -14.61 -0.62 9.69e-38 Vitiligo; LUSC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg17279839 chr7:150038598 RARRES2 0.49 7.28 0.37 2.46e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg15534755 chr11:117069859 TAGLN -0.35 -5.98 -0.31 5.83e-9 Blood protein levels; LUSC cis rs3806843 0.518 rs2569188 chr5:140008419 G/A cg19875535 chr5:140030758 IK -0.48 -7.82 -0.39 6.95e-14 Depressive symptoms (multi-trait analysis); LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg06914050 chr7:56119237 PSPH;CCT6A 0.41 6.22 0.32 1.47e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs6977660 0.714 rs12537283 chr7:19817658 G/T cg07541023 chr7:19748670 TWISTNB 0.62 6.71 0.34 8.21e-11 Thyroid stimulating hormone; LUSC cis rs1801251 1.000 rs283486 chr2:233644223 A/G cg08000102 chr2:233561755 GIGYF2 0.7 11.66 0.54 1.37e-26 Coronary artery disease; LUSC cis rs2074585 0.839 rs11638780 chr15:91041896 G/T cg10434728 chr15:90938212 IQGAP1 -0.45 -9.14 -0.45 6.2e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs10090774 0.965 rs11785430 chr8:142009527 A/G cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 6.09 0.32 3.19e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs12900413 0.603 rs12907030 chr15:90301439 C/T cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9747201 0.926 rs35131420 chr17:80103631 T/C cg18209359 chr17:80159595 CCDC57 0.39 6.44 0.33 4.06e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC cis rs11098499 0.954 rs12510138 chr4:120423935 C/G cg24375607 chr4:120327624 NA 0.8 11.95 0.55 1.22e-27 Corneal astigmatism; LUSC cis rs4629180 0.727 rs10188564 chr2:102101064 C/A cg04415270 chr2:102091202 RFX8 -0.55 -8.67 -0.43 1.84e-16 Chronic rhinosinusitis with nasal polyps; LUSC cis rs1728785 0.901 rs1645974 chr16:68564774 C/G cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs6964587 1.000 rs34548928 chr7:91668365 G/A cg17063962 chr7:91808500 NA 0.6 9.41 0.46 8.58e-19 Breast cancer; LUSC cis rs10489202 0.686 rs12754453 chr1:167844896 A/T cg24449463 chr1:168025552 DCAF6 -0.55 -6.27 -0.32 1.1e-9 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10477989 chr11:68039601 C11orf24 0.47 7.51 0.38 5.43e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg21280719 chr6:42927975 GNMT -0.31 -7.76 -0.39 1.02e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg06636001 chr8:8085503 FLJ10661 0.8 13.35 0.59 7.22e-33 Systolic blood pressure; LUSC trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg20587970 chr11:113659929 NA -1.16 -13.14 -0.58 4.33e-32 Hip circumference adjusted for BMI; LUSC cis rs9486719 1.000 rs2472884 chr6:96863965 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs7178572 0.568 rs4886862 chr15:77652368 T/C cg22256960 chr15:77711686 NA -0.5 -8.07 -0.4 1.26e-14 Type 2 diabetes; LUSC cis rs977987 0.806 rs4888416 chr16:75449176 C/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.66 -0.34 1.15e-10 Dupuytren's disease; LUSC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg03433033 chr1:76189801 ACADM 0.8 13.16 0.58 3.68e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs35264875 0.808 rs2305498 chr11:68866914 G/A cg02660097 chr11:68866761 NA 0.43 6.6 0.34 1.6e-10 Blond vs. brown hair color; LUSC cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg05110241 chr16:68378359 PRMT7 -0.58 -6.72 -0.35 7.89e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.63 0.39 2.51e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs56390833 1 rs56390833 chr15:78877381 C/A cg06917634 chr15:78832804 PSMA4 -0.43 -5.84 -0.3 1.26e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs79040073 0.911 rs11638981 chr15:49321529 A/G cg12040278 chr2:37572396 QPCT -0.42 -6.02 -0.31 4.66e-9 Lung cancer in ever smokers; LUSC cis rs7903847 0.642 rs2297668 chr10:99160046 C/T cg08345082 chr10:99160200 RRP12 -0.33 -6.79 -0.35 5.16e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs6582630 0.585 rs12422588 chr12:38478675 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.47 -0.33 3.57e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs6952808 0.743 rs4719308 chr7:1877502 T/G cg11244813 chr1:145039882 PDE4DIP 0.36 5.96 0.31 6.51e-9 Bipolar disorder and schizophrenia; LUSC cis rs1832871 0.672 rs9456295 chr6:158772078 G/A cg07165851 chr6:158734300 TULP4 0.47 7.16 0.36 5.2e-12 Height; LUSC trans rs4718428 0.705 rs4718430 chr7:66432024 G/T cg18876405 chr7:65276391 NA 0.5 6.53 0.34 2.46e-10 Corneal structure; LUSC cis rs6058796 1.000 rs9636547 chr20:31262033 T/A cg13636640 chr20:31349939 DNMT3B 0.53 5.67 0.3 3.13e-8 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg17724175 chr1:150552817 MCL1 0.37 6.71 0.34 8.42e-11 Tonsillectomy; LUSC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.92 -13.3 -0.59 1.15e-32 Chronic sinus infection; LUSC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg22437258 chr11:111473054 SIK2 -0.43 -5.65 -0.3 3.35e-8 Primary sclerosing cholangitis; LUSC cis rs1160297 0.643 rs13031599 chr2:53075902 T/C cg07782112 chr2:53107842 NA 0.4 6.39 0.33 5.73e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs500891 0.525 rs12529407 chr6:84062581 C/T cg08257003 chr6:84140564 ME1 -0.34 -8.3 -0.41 2.69e-15 Platelet-derived growth factor BB levels; LUSC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.68 0.57 2.38e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 8.09 0.4 1.1e-14 Bipolar disorder; LUSC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg21028142 chr17:79581711 NPLOC4 0.35 8.24 0.41 4.03e-15 Eye color traits; LUSC cis rs870825 1.000 rs9995633 chr4:185584441 C/T cg04058563 chr4:185651563 MLF1IP 0.81 11.67 0.54 1.3e-26 Blood protein levels; LUSC cis rs1371867 0.846 rs2919469 chr8:101233896 C/T cg06636551 chr8:101224915 SPAG1 -0.43 -8.0 -0.4 2.12e-14 Atrioventricular conduction; LUSC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg03806693 chr22:41940476 POLR3H -0.96 -13.04 -0.58 1.08e-31 Vitiligo; LUSC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg12927641 chr6:109611667 NA -0.43 -7.5 -0.38 5.64e-13 Reticulocyte fraction of red cells; LUSC cis rs3857536 0.813 rs7757647 chr6:66947207 A/G cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs66716358 0.800 rs10838255 chr11:44320172 C/T cg02785814 chr11:44338707 NA -0.41 -6.15 -0.32 2.23e-9 Monobrow; LUSC trans rs35110281 0.548 rs2838350 chr21:45109972 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.57 0.5 1.01e-22 Mean corpuscular volume; LUSC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg09021430 chr5:549028 NA -0.57 -8.23 -0.41 4.36e-15 Obesity-related traits; LUSC cis rs6964587 0.839 rs10808086 chr7:91447515 T/C cg17063962 chr7:91808500 NA 0.57 8.61 0.43 2.86e-16 Breast cancer; LUSC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg12463550 chr7:65579703 CRCP 0.44 6.23 0.32 1.38e-9 Aortic root size; LUSC cis rs4423214 0.840 rs1540127 chr11:71179038 G/A cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC cis rs300703 0.719 rs385909 chr2:199678 A/G cg21211680 chr2:198530 NA 0.66 7.45 0.38 7.91e-13 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22737917 chr5:73936437 ENC1 -0.4 -6.01 -0.31 4.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs868036 0.609 rs2127163 chr15:68090842 C/T cg05925327 chr15:68127851 NA -0.48 -7.03 -0.36 1.21e-11 Restless legs syndrome; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg12143784 chr7:64541923 NA 0.42 6.55 0.34 2.21e-10 Calcium levels; LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg08219700 chr8:58056026 NA 0.64 8.25 0.41 3.65e-15 Developmental language disorder (linguistic errors); LUSC cis rs6977660 0.941 rs5017192 chr7:19820114 C/T cg05791153 chr7:19748676 TWISTNB 0.52 5.78 0.3 1.69e-8 Thyroid stimulating hormone; LUSC cis rs7215564 0.818 rs35059200 chr17:78661619 T/C cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs7592578 0.639 rs61709084 chr2:191287685 A/C cg11845111 chr2:191398756 TMEM194B -0.81 -11.01 -0.52 2.86e-24 Diastolic blood pressure; LUSC cis rs6120849 0.708 rs6087659 chr20:33606383 C/A cg24642439 chr20:33292090 TP53INP2 0.62 6.8 0.35 4.74e-11 Protein C levels; LUSC cis rs7927592 0.871 rs55953412 chr11:68328283 C/T cg20283391 chr11:68216788 NA -0.6 -8.4 -0.42 1.25e-15 Total body bone mineral density; LUSC cis rs4660306 1.000 rs2077808 chr1:45988115 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.53 -0.34 2.48e-10 Homocysteine levels; LUSC cis rs4356932 0.691 rs9307050 chr4:76905649 G/A cg00809888 chr4:76862425 NAAA 0.37 5.88 0.31 9.75e-9 Blood protein levels; LUSC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg07424592 chr7:64974309 NA 0.69 6.07 0.32 3.4e-9 Diabetic kidney disease; LUSC cis rs6060717 0.536 rs6060666 chr20:34478954 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.67 -0.3 3.14e-8 Hip circumference adjusted for BMI; LUSC cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg12310025 chr6:25882481 NA -0.5 -9.06 -0.44 1.09e-17 Blood metabolite levels; LUSC cis rs11098499 0.618 rs6858383 chr4:120296772 T/C cg24375607 chr4:120327624 NA 0.78 11.52 0.53 4.39e-26 Corneal astigmatism; LUSC cis rs6847149 0.929 rs4698752 chr4:110780964 A/G cg07850274 chr4:110748770 RRH 0.56 7.95 0.4 2.98e-14 Exercise treadmill test traits; LUSC cis rs4713675 0.546 rs10947430 chr6:33658534 G/A cg14003231 chr6:33640908 ITPR3 0.31 5.96 0.31 6.39e-9 Plateletcrit; LUSC trans rs8072100 0.934 rs9905583 chr17:45741016 C/T cg03886242 chr7:26192032 NFE2L3 -0.38 -6.3 -0.33 9.38e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4595586 0.545 rs4768526 chr12:39402898 A/G cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.64e-11 Morning vs. evening chronotype; LUSC trans rs7824557 0.628 rs11250129 chr8:11202154 G/A cg06636001 chr8:8085503 FLJ10661 0.44 6.37 0.33 6.14e-10 Retinal vascular caliber; LUSC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs1215050 0.791 rs260889 chr4:98742340 A/G cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.25e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg07716408 chr11:68623521 NA -0.34 -6.65 -0.34 1.23e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769707 0.521 rs6009807 chr22:50058922 A/G cg20744362 chr22:50050164 C22orf34 0.36 6.66 0.34 1.1e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9467773 0.526 rs12199613 chr6:26367218 C/T cg09904177 chr6:26538194 HMGN4 -0.48 -7.56 -0.38 3.93e-13 Intelligence (multi-trait analysis); LUSC cis rs9549367 0.789 rs7317558 chr13:113893625 G/A cg00898013 chr13:113819073 PROZ -0.53 -7.9 -0.4 4e-14 Platelet distribution width; LUSC cis rs7255374 0.566 rs7255904 chr19:41529020 C/T cg20630647 chr19:41531805 NA 0.38 6.37 0.33 6.2e-10 DDT metabolite (p,p'-DDE levels); LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.57 0.57 6.4e-30 Prudent dietary pattern; LUSC trans rs7937682 0.575 rs34558891 chr11:111737912 C/T cg18187862 chr3:45730750 SACM1L -0.51 -6.17 -0.32 1.99e-9 Primary sclerosing cholangitis; LUSC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg24733560 chr20:60626293 TAF4 0.4 6.52 0.34 2.58e-10 Body mass index; LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg18099408 chr3:52552593 STAB1 0.42 7.22 0.37 3.55e-12 Bipolar disorder; LUSC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg18230493 chr5:56204884 C5orf35 0.76 12.7 0.57 2.05e-30 Initial pursuit acceleration; LUSC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg22823121 chr1:150693482 HORMAD1 0.49 7.0 0.36 1.37e-11 Melanoma; LUSC trans rs877282 0.898 rs12356744 chr10:757477 G/C cg13042288 chr15:90349979 ANPEP -0.47 -6.51 -0.34 2.71e-10 Uric acid levels; LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs2289583 0.544 rs1867153 chr15:75271229 C/T cg14664628 chr15:75095509 CSK 0.44 5.99 0.31 5.36e-9 Systemic lupus erythematosus; LUSC cis rs34779708 0.931 rs67261877 chr10:35386340 T/A cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9463078 0.665 rs4714816 chr6:44715168 T/C cg25276700 chr6:44698697 NA 0.31 6.34 0.33 7.59e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7572644 0.699 rs7595847 chr2:28173043 T/A cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.89e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11785400 0.793 rs12546978 chr8:143750205 T/A cg10596483 chr8:143751796 JRK -0.51 -7.31 -0.37 1.98e-12 Schizophrenia; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg15130241 chr1:1334814 CCNL2;LOC148413 0.36 6.06 0.31 3.77e-9 Metabolite levels (Pyroglutamine); LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.28e-9 Menopause (age at onset); LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg13395646 chr4:1353034 KIAA1530 -0.79 -13.54 -0.6 1.32e-33 Obesity-related traits; LUSC cis rs1448094 0.802 rs7397730 chr12:86416212 T/C cg00310523 chr12:86230176 RASSF9 0.35 6.37 0.33 6.28e-10 Major depressive disorder; LUSC cis rs4237845 0.680 rs10877033 chr12:58283731 T/C cg02175503 chr12:58329896 NA 0.59 9.29 0.45 1.99e-18 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.19 -0.32 1.8e-9 Major depressive disorder; LUSC cis rs6969780 0.915 rs886339 chr7:27190670 A/C cg26364809 chr7:27145159 NA 0.53 5.92 0.31 7.97e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs7246657 0.943 rs4803347 chr19:37848017 G/A cg23950597 chr19:37808831 NA -0.63 -7.77 -0.39 9.76e-14 Coronary artery calcification; LUSC trans rs9944715 0.954 rs36191490 chr18:43839653 C/T cg01718231 chr17:29326311 RNF135 -0.51 -7.09 -0.36 8.1e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs9467773 0.609 rs12663780 chr6:26397573 T/C cg05738196 chr6:26577821 NA -0.47 -6.72 -0.35 7.73e-11 Intelligence (multi-trait analysis); LUSC cis rs8081692 1 rs8081692 chr17:38154595 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.94 -0.35 2.08e-11 Neutrophil count; LUSC cis rs7246657 0.943 rs4803460 chr19:37885228 T/C cg23950597 chr19:37808831 NA -0.64 -7.72 -0.39 1.35e-13 Coronary artery calcification; LUSC cis rs56163509 1 rs56163509 chr16:28864471 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.86 0.31 1.13e-8 Tonsillectomy;Mean corpuscular volume; LUSC cis rs2228479 0.867 rs73276534 chr16:89950557 A/G cg06558623 chr16:89946397 TCF25 0.95 10.21 0.49 1.82e-21 Skin colour saturation; LUSC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg05623727 chr3:50126028 RBM5 -0.34 -6.29 -0.33 9.97e-10 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg17971929 chr21:40555470 PSMG1 0.8 14.01 0.61 2.13e-35 Cognitive function; LUSC cis rs6964587 0.626 rs409 chr7:91556355 C/T cg17063962 chr7:91808500 NA 0.56 9.29 0.45 2.06e-18 Breast cancer; LUSC cis rs56104184 0.887 rs4801778 chr19:49370609 G/T cg15549821 chr19:49342101 PLEKHA4 -0.57 -7.78 -0.39 8.92e-14 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs1348850 0.793 rs12990917 chr2:178487259 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.12 0.32 2.65e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.54 6.96 0.36 1.78e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs9888739 0.668 rs9933520 chr16:31343386 A/G cg15817542 chr16:31343056 ITGAM -0.53 -7.13 -0.36 6.08e-12 Systemic lupus erythematosus; LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg07414643 chr4:187882934 NA 0.55 10.1 0.48 4.14e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs7084921 0.608 rs12780510 chr10:101865881 T/C cg11888571 chr10:102027403 CWF19L1 -0.42 -5.84 -0.3 1.27e-8 Bone mineral density; LUSC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg18252515 chr7:66147081 NA -1.19 -13.96 -0.61 3.37e-35 Diabetic kidney disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14347670 chr6:41908995 CCND3 0.49 7.22 0.37 3.62e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg14092988 chr3:52407081 DNAH1 0.41 7.34 0.37 1.66e-12 Bipolar disorder; LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg24675658 chr1:53192096 ZYG11B 0.58 9.11 0.45 7.6e-18 Monocyte count; LUSC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12756686 chr19:29218302 NA 0.68 9.63 0.47 1.54e-19 Methadone dose in opioid dependence; LUSC trans rs12579753 0.871 rs1922540 chr12:82197496 A/G cg07923666 chr12:49932857 KCNH3 -0.52 -6.51 -0.34 2.74e-10 Resting heart rate; LUSC cis rs4964805 0.683 rs12424737 chr12:104196221 A/C cg02344784 chr12:104178138 NT5DC3 0.46 8.83 0.44 5.86e-17 Attention deficit hyperactivity disorder; LUSC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.65 -0.3 3.35e-8 Life satisfaction; LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg08088566 chr11:430123 ANO9 0.61 7.12 0.36 6.5e-12 Body mass index; LUSC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg03517284 chr6:25882590 NA -0.45 -7.66 -0.39 1.99e-13 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg26513180 chr16:89883248 FANCA -0.53 -7.84 -0.39 6.09e-14 Vitiligo; LUSC trans rs11039798 0.620 rs10838833 chr11:48238880 C/T cg03929089 chr4:120376271 NA 0.65 6.08 0.32 3.36e-9 Axial length; LUSC cis rs2688608 0.592 rs2306328 chr10:75579510 C/T cg23231163 chr10:75533350 FUT11 -0.43 -6.93 -0.35 2.21e-11 Inflammatory bowel disease; LUSC trans rs11039798 1.000 rs12280020 chr11:48618844 G/C cg15704280 chr7:45808275 SEPT13 0.68 6.41 0.33 4.99e-10 Axial length; LUSC trans rs1459104 0.777 rs116287458 chr11:54916623 G/A cg15704280 chr7:45808275 SEPT13 0.69 5.97 0.31 6.07e-9 Body mass index; LUSC cis rs2463822 0.844 rs2513737 chr11:62119495 G/C cg06239285 chr11:62104954 ASRGL1 0.98 10.97 0.51 4.05e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9443645 0.509 rs12176511 chr6:79565721 G/A cg05283184 chr6:79620031 NA 0.51 10.26 0.49 1.15e-21 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg07507251 chr3:52567010 NT5DC2 0.31 6.14 0.32 2.33e-9 Bipolar disorder; LUSC cis rs10979 0.965 rs9496674 chr6:143886106 G/T cg25407410 chr6:143891975 LOC285740 -0.74 -12.09 -0.55 3.66e-28 Hypospadias; LUSC cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg01579765 chr21:45077557 HSF2BP 0.45 9.62 0.47 1.63e-19 Mean corpuscular volume; LUSC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg25554036 chr4:6271136 WFS1 0.62 12.77 0.57 1.08e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1832871 0.644 rs56180963 chr6:158773990 G/A cg07165851 chr6:158734300 TULP4 0.48 7.32 0.37 1.87e-12 Height; LUSC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg19920283 chr7:105172520 RINT1 0.6 6.38 0.33 5.9e-10 Bipolar disorder (body mass index interaction); LUSC cis rs912057 0.833 rs1294424 chr6:6744135 G/A cg06612196 chr6:6737390 NA 0.54 10.25 0.49 1.27e-21 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs55728055 0.661 rs7286496 chr22:31983760 G/A cg01338084 chr22:32026380 PISD 0.93 6.78 0.35 5.4e-11 Age-related hearing impairment; LUSC cis rs3020736 0.500 rs9620026 chr22:42498578 C/T cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs748404 0.578 rs573615 chr15:43614281 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.46 6.28 0.33 1.04e-9 Lung cancer; LUSC cis rs3849570 1.000 rs6548773 chr3:81840222 C/T cg07356753 chr3:81810745 GBE1 0.7 11.56 0.53 3.2e-26 Waist circumference;Body mass index; LUSC cis rs911119 1.000 rs734801 chr20:23612791 A/G cg16589663 chr20:23618590 CST3 0.58 6.88 0.35 2.94e-11 Chronic kidney disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg17819983 chr9:140189914 NA 0.4 6.3 0.33 9.16e-10 Risky sexual behaviors in alcohol dependence; LUSC trans rs9291683 0.585 rs12648479 chr4:10104571 G/A cg26043149 chr18:55253948 FECH -0.54 -8.11 -0.41 9.44e-15 Bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23414580 chr4:4145323 NA 0.39 5.95 0.31 6.69e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11890956 chr21:40555474 PSMG1 -0.77 -11.82 -0.54 3.46e-27 Menarche (age at onset); LUSC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg21862992 chr11:68658383 NA 0.5 8.08 0.4 1.19e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs61931739 0.649 rs815047 chr12:33726459 C/T cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC trans rs6951245 0.554 rs75075857 chr7:1140298 C/T cg13565492 chr6:43139072 SRF -0.73 -10.83 -0.51 1.25e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 3.96e-12 Motion sickness; LUSC cis rs3820068 0.705 rs4646022 chr1:15839112 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.84 0.3 1.23e-8 Systolic blood pressure; LUSC cis rs11025559 0.796 rs10833317 chr11:20412277 A/T cg19653624 chr11:20408972 PRMT3 -0.68 -8.71 -0.43 1.41e-16 Pursuit maintenance gain; LUSC cis rs60695258 0.512 rs2053770 chr4:87908085 C/T cg10685359 chr4:87814065 C4orf36 0.33 5.81 0.3 1.49e-8 Hematocrit; LUSC cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.45 6.26 0.32 1.21e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg15445000 chr17:37608096 MED1 -0.39 -6.69 -0.34 9.47e-11 Glomerular filtration rate (creatinine); LUSC cis rs28735056 1.000 rs56376220 chr18:77609462 C/T cg20368463 chr18:77673604 PQLC1 -0.5 -7.21 -0.37 3.73e-12 Schizophrenia; LUSC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg00509249 chr6:109615579 CCDC162 -0.32 -5.73 -0.3 2.24e-8 Reticulocyte fraction of red cells; LUSC cis rs68170813 0.652 rs74374590 chr7:107172470 G/A cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs6977660 1.000 rs2892940 chr7:19794750 G/A cg05791153 chr7:19748676 TWISTNB 0.66 7.34 0.37 1.68e-12 Thyroid stimulating hormone; LUSC cis rs9325144 0.505 rs7138977 chr12:38642109 G/A cg26384229 chr12:38710491 ALG10B 0.78 12.81 0.57 7.56e-31 Morning vs. evening chronotype; LUSC cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs6700896 0.966 rs3790439 chr1:66085574 T/A cg04111102 chr1:66153794 NA 0.32 7.07 0.36 8.85e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7560272 0.549 rs2421554 chr2:73806202 A/T cg20560298 chr2:73613845 ALMS1 -0.43 -6.51 -0.34 2.74e-10 Schizophrenia; LUSC cis rs11630290 0.592 rs12324556 chr15:64160951 G/A cg12036633 chr15:63758958 NA 0.54 6.93 0.35 2.19e-11 Iris characteristics; LUSC cis rs17828380 0.920 rs35893526 chr15:63455686 C/T cg05507819 chr15:63340323 TPM1 -0.75 -6.12 -0.32 2.61e-9 Social communication problems; LUSC cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg24642439 chr20:33292090 TP53INP2 -0.5 -7.5 -0.38 5.92e-13 Glomerular filtration rate (creatinine); LUSC cis rs2798269 1.000 rs12430902 chr13:22146005 T/C cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.94 -0.31 7.18e-9 PR segment; LUSC cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg21535247 chr6:8435926 SLC35B3 0.56 8.45 0.42 8.88e-16 Motion sickness; LUSC cis rs2766692 1.000 rs4905941 chr14:100725438 A/G cg14866419 chr14:100704911 YY1 0.46 6.08 0.32 3.22e-9 Electroencephalographic traits in alcoholism; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg11050988 chr7:1952600 MAD1L1 -0.32 -6.11 -0.32 2.76e-9 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg04369109 chr6:150039330 LATS1 -0.56 -8.31 -0.41 2.47e-15 Lung cancer; LUSC trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.6 -0.43 3.13e-16 Neuroticism; LUSC cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.15e-8 Breast cancer; LUSC cis rs12200560 0.505 rs4839848 chr6:97076577 G/A cg06623918 chr6:96969491 KIAA0776 0.5 7.21 0.37 3.75e-12 Coronary heart disease; LUSC cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.61 0.65 1.27e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs4474465 1.000 rs12280198 chr11:78161361 C/T cg27205649 chr11:78285834 NARS2 -0.53 -6.26 -0.32 1.16e-9 Alzheimer's disease (survival time); LUSC cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg08997352 chr12:9597637 DDX12 -0.59 -9.66 -0.47 1.26e-19 Breast size; LUSC cis rs17095355 0.818 rs4275548 chr10:111910971 A/G cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.33 -0.37 1.74e-12 Biliary atresia; LUSC cis rs1215050 0.716 rs356549 chr4:98699344 A/G cg05340658 chr4:99064831 C4orf37 0.44 6.9 0.35 2.57e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2637266 1.000 rs17384253 chr10:78342391 A/G cg18941641 chr10:78392320 NA 0.39 7.08 0.36 8.42e-12 Pulmonary function; LUSC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9467773 0.620 rs2494696 chr6:26620894 A/G cg09904177 chr6:26538194 HMGN4 0.65 11.67 0.54 1.3e-26 Intelligence (multi-trait analysis); LUSC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg16414030 chr3:133502952 NA -0.42 -6.22 -0.32 1.49e-9 Iron status biomarkers; LUSC trans rs7824557 0.670 rs2736381 chr8:11132766 A/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.45 -0.42 9.26e-16 Retinal vascular caliber; LUSC cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg01256987 chr12:42539512 GXYLT1 -0.6 -12.79 -0.57 9.16e-31 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2667011 0.512 rs10177852 chr2:160820410 T/C cg06573604 chr2:160760825 LY75 -0.45 -6.63 -0.34 1.32e-10 Bilirubin levels; LUSC cis rs911119 0.913 rs6048922 chr20:23578116 G/C cg16589663 chr20:23618590 CST3 0.6 7.02 0.36 1.21e-11 Chronic kidney disease; LUSC trans rs9329221 0.870 rs11777976 chr8:10255402 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.24 -0.41 4.03e-15 Neuroticism; LUSC cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg03146154 chr1:46216737 IPP 0.51 7.48 0.38 6.55e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7829975 0.714 rs4841042 chr8:8664622 A/G cg21775007 chr8:11205619 TDH -0.43 -6.22 -0.32 1.45e-9 Mood instability; LUSC cis rs662064 0.928 rs685746 chr1:10537437 C/G cg20482658 chr1:10539492 PEX14 -0.3 -6.28 -0.32 1.07e-9 Asthma; LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg03934478 chr11:495069 RNH1 0.85 10.24 0.49 1.37e-21 Body mass index; LUSC cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs9309473 0.615 rs62149774 chr2:73787652 G/A cg20560298 chr2:73613845 ALMS1 -0.55 -6.56 -0.34 2.1e-10 Metabolite levels; LUSC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg23590916 chr17:43697445 MGC57346 -0.48 -6.51 -0.34 2.7e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.7 -0.43 1.57e-16 Mood instability; LUSC cis rs56104184 0.775 rs17272707 chr19:49404535 T/G cg15549821 chr19:49342101 PLEKHA4 -0.52 -6.12 -0.32 2.61e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg03806693 chr22:41940476 POLR3H 1.0 14.25 0.62 2.41e-36 Vitiligo; LUSC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.97 0.31 6.13e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg11645453 chr3:52864694 ITIH4 -0.31 -7.48 -0.38 6.7e-13 Electroencephalogram traits; LUSC cis rs66887589 0.870 rs2389875 chr4:120557014 G/T cg09307838 chr4:120376055 NA -0.51 -7.54 -0.38 4.53e-13 Diastolic blood pressure; LUSC cis rs9283706 0.594 rs7717020 chr5:66353322 A/C cg11590213 chr5:66331682 MAST4 0.48 7.07 0.36 9.12e-12 Coronary artery disease; LUSC cis rs754133 0.964 rs894737 chr12:54418143 A/C cg10005224 chr12:54424964 HOXC4;HOXC5 0.43 8.61 0.43 3.03e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs6701037 0.681 rs1057246 chr1:175127534 C/G cg00321850 chr1:175162397 KIAA0040 0.41 7.22 0.37 3.5e-12 Alcohol dependence; LUSC cis rs11785693 0.862 rs11786186 chr8:4999059 G/C cg26367366 chr8:4980734 NA 0.8 9.4 0.46 8.84e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg02772935 chr3:125709198 NA -0.48 -5.84 -0.3 1.23e-8 Blood pressure (smoking interaction); LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.55 -8.19 -0.41 5.5e-15 Lymphocyte counts; LUSC cis rs870825 0.616 rs7683799 chr4:185632164 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.2 0.59 2.54e-32 Blood protein levels; LUSC cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.62 0.43 2.64e-16 Menarche (age at onset); LUSC cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.909 rs6119725 chr20:30385557 G/T cg13852791 chr20:30311386 BCL2L1 0.87 11.6 0.54 2.35e-26 Mean corpuscular hemoglobin; LUSC cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg06784218 chr1:46089804 CCDC17 0.56 11.62 0.54 1.92e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1799949 0.794 rs116409325 chr17:41445460 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.38 6.09 0.32 3.04e-9 Menopause (age at onset); LUSC cis rs10911363 0.592 rs2782411 chr1:183476929 G/A cg09173681 chr1:183549694 NCF2 0.65 11.52 0.53 4.42e-26 Systemic lupus erythematosus; LUSC cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg26395211 chr5:140044315 WDR55 0.45 7.02 0.36 1.22e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg02487422 chr3:49467188 NICN1 0.47 7.36 0.37 1.45e-12 Resting heart rate; LUSC cis rs2294693 0.945 rs13216361 chr6:41007046 C/T cg14769373 chr6:40998127 UNC5CL -0.54 -7.23 -0.37 3.27e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs80282103 0.764 rs12268949 chr10:1104257 A/G cg18964960 chr10:1102726 WDR37 0.71 6.31 0.33 9.01e-10 Glomerular filtration rate (creatinine); LUSC trans rs1409005 1.000 rs76093584 chr13:79154632 C/T cg04653021 chr3:122514541 DIRC2 0.47 6.04 0.31 4.05e-9 Serum thyroid-stimulating hormone levels; LUSC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg18196295 chr10:418757 DIP2C -0.46 -7.26 -0.37 2.77e-12 Psychosis in Alzheimer's disease; LUSC cis rs8077889 0.917 rs58283314 chr17:41905963 T/G cg26893861 chr17:41843967 DUSP3 0.86 13.17 0.58 3.36e-32 Triglycerides; LUSC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg26677194 chr12:130822605 PIWIL1 0.59 8.8 0.43 7.28e-17 Menopause (age at onset); LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.4 -6.13 -0.32 2.42e-9 Lymphocyte counts; LUSC cis rs7809950 1.000 rs3801954 chr7:107117048 C/T cg23024343 chr7:107201750 COG5 -0.55 -8.85 -0.44 5.22e-17 Coronary artery disease; LUSC cis rs72634258 0.945 rs28624 chr1:8084355 G/T cg26816564 chr1:7831052 VAMP3 -0.46 -6.2 -0.32 1.69e-9 Inflammatory bowel disease; LUSC cis rs4728302 0.559 rs12707093 chr7:133200817 C/T cg10665199 chr7:133106180 EXOC4 0.53 7.29 0.37 2.23e-12 Intelligence;Intelligence (multi-trait analysis); LUSC cis rs113835537 0.529 rs78999944 chr11:66251228 C/G cg24851651 chr11:66362959 CCS 0.54 8.02 0.4 1.77e-14 Airway imaging phenotypes; LUSC cis rs6495122 0.532 rs2470890 chr15:75047426 C/T cg14664628 chr15:75095509 CSK -0.68 -10.25 -0.49 1.26e-21 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs4319547 1.000 rs6489157 chr12:123101673 C/G cg05707623 chr12:122985044 ZCCHC8 0.64 8.64 0.43 2.28e-16 Body mass index; LUSC cis rs17376456 0.542 rs17083380 chr5:93170476 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.48 -6.43 -0.33 4.34e-10 Diabetic retinopathy; LUSC cis rs25645 0.502 rs9895948 chr17:38108363 T/C cg26162295 chr17:38119207 GSDMA -0.28 -6.33 -0.33 8.07e-10 Myeloid white cell count; LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -5.9 -0.31 9.1e-9 Developmental language disorder (linguistic errors); LUSC cis rs12980942 0.872 rs7256416 chr19:41787931 C/T cg25627403 chr19:41769009 HNRNPUL1 0.59 6.49 0.33 3.13e-10 Coronary artery disease; LUSC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.63 0.5 6.47e-23 Menopause (age at onset); LUSC cis rs981844 0.712 rs897610 chr4:154755439 C/A cg14289246 chr4:154710475 SFRP2 -0.45 -6.22 -0.32 1.45e-9 Response to statins (LDL cholesterol change); LUSC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs12545109 0.571 rs4314648 chr8:57276937 G/A cg09654669 chr8:57350985 NA -0.47 -5.97 -0.31 6.2e-9 Obesity-related traits; LUSC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg13902645 chr11:5959945 NA -0.54 -8.27 -0.41 3.28e-15 DNA methylation (variation); LUSC cis rs7267979 1.000 rs6083862 chr20:25411086 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.8 -17.95 -0.7 6.6e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4319547 0.506 rs2062488 chr12:122804256 C/T cg23029597 chr12:123009494 RSRC2 0.54 6.91 0.35 2.52e-11 Body mass index; LUSC cis rs1018836 0.770 rs13266461 chr8:91652817 T/C cg16814680 chr8:91681699 NA -0.95 -18.22 -0.71 5.41e-52 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9467773 1.000 rs767471 chr6:26557854 C/T cg09904177 chr6:26538194 HMGN4 0.76 14.16 0.61 5.54e-36 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg11871910 chr12:69753446 YEATS4 0.71 11.97 0.55 1.05e-27 Blood protein levels; LUSC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg01416388 chr22:39784598 NA -0.45 -7.61 -0.38 2.76e-13 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg21361702 chr7:150065534 REPIN1 0.53 6.99 0.36 1.49e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs11690935 0.549 rs796839 chr2:172916214 A/C cg13550731 chr2:172543902 DYNC1I2 0.55 8.55 0.42 4.61e-16 Schizophrenia; LUSC trans rs2562456 0.833 rs552800 chr19:21484642 G/A cg00806126 chr19:22604979 ZNF98 0.4 6.2 0.32 1.67e-9 Pain; LUSC cis rs6840360 1.000 rs4696104 chr4:152600451 A/G cg22705602 chr4:152727874 NA -0.27 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs2458413 0.903 rs2669448 chr8:105372324 T/G cg04554929 chr8:105342491 NA 0.33 5.74 0.3 2.08e-8 Paget's disease; LUSC cis rs12908161 1.000 rs12903134 chr15:85337699 T/A cg17173187 chr15:85201210 NMB 0.47 8.87 0.44 4.36e-17 Schizophrenia; LUSC cis rs477692 0.673 rs579325 chr10:131363688 C/T cg05714579 chr10:131428358 MGMT 0.45 6.24 0.32 1.32e-9 Response to temozolomide; LUSC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg21724239 chr8:58056113 NA 0.61 7.21 0.37 3.7e-12 Developmental language disorder (linguistic errors); LUSC cis rs28655083 0.529 rs285018 chr16:77099065 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.42 6.74 0.35 6.79e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg10909506 chr17:38081995 ORMDL3 -0.34 -5.97 -0.31 6.07e-9 Self-reported allergy; LUSC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.47 -7.02 -0.36 1.26e-11 Alzheimer's disease (late onset); LUSC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.79 -0.39 8.31e-14 Intelligence (multi-trait analysis); LUSC cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -9.02 -0.44 1.46e-17 Axial length; LUSC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg14500267 chr11:67383377 NA 0.34 6.43 0.33 4.44e-10 Mean corpuscular volume; LUSC cis rs9527 0.545 rs12247514 chr10:104958066 C/A cg04362960 chr10:104952993 NT5C2 0.62 9.85 0.47 2.95e-20 Arsenic metabolism; LUSC trans rs11696501 0.588 rs6073831 chr20:44279550 A/T cg03272292 chr12:48577362 C12orf68 0.48 6.0 0.31 5.1e-9 Brain structure; LUSC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg25258033 chr6:167368657 RNASET2 0.47 7.69 0.39 1.63e-13 Crohn's disease; LUSC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg26335602 chr6:28129616 ZNF389 0.45 6.18 0.32 1.84e-9 Depression; LUSC cis rs7071206 0.891 rs10824559 chr10:79409222 A/G cg07817648 chr10:79422355 NA -0.56 -7.38 -0.37 1.29e-12 Bone mineral density; LUSC cis rs8072100 0.837 rs62074055 chr17:45771933 G/C cg08085267 chr17:45401833 C17orf57 -0.54 -8.64 -0.43 2.4e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg11764359 chr7:65958608 NA -0.63 -9.62 -0.47 1.67e-19 Aortic root size; LUSC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg04450456 chr4:17643702 FAM184B 0.39 6.61 0.34 1.51e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs73206853 0.764 rs16940881 chr12:110937818 G/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs8067287 0.597 rs7223652 chr17:16864559 C/T cg26910001 chr17:16838321 NA 0.38 5.98 0.31 5.61e-9 Diabetic kidney disease; LUSC cis rs7523273 0.606 rs2488252 chr1:207938228 C/T cg22525895 chr1:207977042 MIR29B2 0.41 6.69 0.34 9.54e-11 Schizophrenia; LUSC cis rs295140 0.526 rs295113 chr2:201197816 C/G cg04283868 chr2:201171347 SPATS2L -0.42 -6.17 -0.32 1.99e-9 QT interval; LUSC cis rs9311676 0.656 rs55727087 chr3:58404547 G/A cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12756686 chr19:29218302 NA 0.66 9.77 0.47 5.41e-20 Methadone dose in opioid dependence; LUSC cis rs17401966 0.838 rs6541089 chr1:10402785 A/G cg19773385 chr1:10388646 KIF1B -0.48 -8.46 -0.42 8.72e-16 Hepatocellular carcinoma; LUSC cis rs12995491 0.933 rs13023008 chr2:88530933 G/A cg18302933 chr2:88491318 NA -0.35 -6.64 -0.34 1.3e-10 Response to metformin (IC50); LUSC cis rs9747201 0.925 rs11867806 chr17:80072049 A/G cg18209359 chr17:80159595 CCDC57 0.37 6.01 0.31 4.87e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs644799 0.710 rs11021309 chr11:95501898 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.07 0.61 1.23e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.53e-8 Menopause (age at onset); LUSC trans rs6480314 0.542 rs10998044 chr10:70029265 A/G cg04882175 chr6:131122610 NA -0.55 -6.3 -0.33 9.45e-10 Optic nerve measurement (disc area); LUSC cis rs826838 1.000 rs10880826 chr12:38672787 G/C cg26384229 chr12:38710491 ALG10B 0.96 17.76 0.7 3.72e-50 Heart rate; LUSC cis rs1801251 1.000 rs13003675 chr2:233584109 C/T cg25237894 chr2:233734115 C2orf82 0.35 6.51 0.34 2.78e-10 Coronary artery disease; LUSC cis rs677665 0.537 rs6688233 chr1:9335745 A/G cg25755851 chr1:9335794 NA -0.82 -13.44 -0.59 3.11e-33 Eosinophil percentage of white cells; LUSC cis rs34366173 1 rs34366173 chr15:63998914 CTT/C cg12036633 chr15:63758958 NA -0.39 -5.66 -0.3 3.19e-8 Reticulocyte fraction of red cells; LUSC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11890956 chr21:40555474 PSMG1 1.04 21.3 0.76 3.4e-64 Cognitive function; LUSC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.87 0.6 7.37e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1728785 0.901 rs8050289 chr16:68566976 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.47e-8 Extrinsic epigenetic age acceleration; LUSC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg17554472 chr22:41940697 POLR3H -0.48 -5.9 -0.31 9.06e-9 Vitiligo; LUSC cis rs6424115 0.692 rs573361 chr1:24053674 A/T cg10978503 chr1:24200527 CNR2 0.45 10.11 0.48 3.84e-21 Immature fraction of reticulocytes; LUSC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg06074448 chr4:187884817 NA -0.41 -6.85 -0.35 3.49e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg24812749 chr6:127587940 RNF146 -0.7 -10.07 -0.48 5.4e-21 Breast cancer; LUSC cis rs6736093 0.966 rs870761 chr2:112745290 A/T cg12686935 chr2:112915763 FBLN7 -0.37 -5.96 -0.31 6.32e-9 Coronary artery disease; LUSC cis rs8072100 0.967 rs2317826 chr17:45730899 C/T cg08085267 chr17:45401833 C17orf57 -0.6 -9.96 -0.48 1.28e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20361001 chr2:9563570 ITGB1BP1;CPSF3 -0.45 -6.57 -0.34 1.97e-10 Electrocardiographic conduction measures; LUSC cis rs4423214 0.840 rs1790343 chr11:71177207 T/C cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.38 -0.33 5.89e-10 Extrinsic epigenetic age acceleration; LUSC trans rs11992162 0.613 rs56094399 chr8:11797470 G/A cg27411982 chr8:10470053 RP1L1 -0.45 -6.89 -0.35 2.81e-11 Monocyte count; LUSC cis rs3806843 0.576 rs246066 chr5:140323147 T/G cg19875535 chr5:140030758 IK 0.38 5.79 0.3 1.66e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9467773 1.000 rs9467782 chr6:26542773 G/A cg09904177 chr6:26538194 HMGN4 0.75 14.27 0.62 2.07e-36 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg06238570 chr21:40685208 BRWD1 -0.63 -10.46 -0.5 2.5e-22 Cognitive function; LUSC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.39 0.33 5.71e-10 Lung cancer; LUSC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg05585544 chr11:47624801 NA -0.42 -7.3 -0.37 2.07e-12 Subjective well-being; LUSC cis rs6831352 0.879 rs7434491 chr4:100069847 G/C cg12011299 chr4:100065546 ADH4 -0.72 -10.42 -0.5 3.38e-22 Alcohol dependence; LUSC trans rs4148689 0.951 rs2027944 chr7:117187659 T/C cg10450175 chr16:88689712 ZC3H18 0.46 5.99 0.31 5.37e-9 Gout; LUSC cis rs250677 0.522 rs55732303 chr5:148392538 C/T cg18129178 chr5:148520854 ABLIM3 -0.53 -7.75 -0.39 1.13e-13 Breast cancer; LUSC cis rs950169 0.840 rs12905223 chr15:85114268 T/C cg11189052 chr15:85197271 WDR73 0.47 5.84 0.3 1.26e-8 Schizophrenia; LUSC cis rs6496667 0.558 rs10459677 chr15:91042399 A/C cg10434728 chr15:90938212 IQGAP1 -0.35 -6.57 -0.34 1.94e-10 Rheumatoid arthritis; LUSC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg06363034 chr20:62225388 GMEB2 -0.46 -7.81 -0.39 7.64e-14 Glioblastoma; LUSC cis rs73001065 0.636 rs11668104 chr19:19426181 G/A cg03709012 chr19:19516395 GATAD2A 0.92 8.48 0.42 7.55e-16 LDL cholesterol; LUSC cis rs10761482 0.690 rs4406773 chr10:62104574 A/G cg18175470 chr10:62150864 ANK3 -0.49 -7.07 -0.36 9.31e-12 Schizophrenia; LUSC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.33 -0.37 1.71e-12 Menarche (age at onset); LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.7 0.39 1.54e-13 Prudent dietary pattern; LUSC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg03676636 chr4:99064102 C4orf37 0.37 8.04 0.4 1.58e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs561341 1.000 rs550264 chr17:30317540 G/T cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs13089785 0.725 rs2222822 chr3:123604788 T/A cg02558132 chr3:123411198 MYLK 0.36 6.07 0.32 3.5e-9 Intelligence (multi-trait analysis); LUSC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg05717871 chr11:638507 DRD4 -0.35 -6.1 -0.32 3.01e-9 Systemic lupus erythematosus; LUSC cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg18225595 chr11:63971243 STIP1 0.6 9.9 0.48 1.98e-20 Platelet count; LUSC cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg13628971 chr7:2884303 GNA12 0.38 5.72 0.3 2.36e-8 Height; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs6424115 1.000 rs7521961 chr1:24157634 C/T cg15997130 chr1:24165203 NA -0.56 -9.19 -0.45 4.43e-18 Immature fraction of reticulocytes; LUSC cis rs3859192 0.539 rs2305481 chr17:38138624 G/A cg17467752 chr17:38218738 THRA -0.5 -6.97 -0.36 1.69e-11 White blood cell count; LUSC trans rs629535 0.814 rs62513371 chr8:70077779 T/A cg21567404 chr3:27674614 NA -0.97 -15.59 -0.65 1.43e-41 Dupuytren's disease; LUSC cis rs12950390 0.776 rs4793646 chr17:45853966 A/C cg03474202 chr17:45855739 NA -0.29 -6.62 -0.34 1.44e-10 IgG glycosylation; LUSC trans rs61931739 0.500 rs6488218 chr12:34452587 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.51 0.59 1.83e-33 Morning vs. evening chronotype; LUSC cis rs61931739 0.517 rs10844802 chr12:34231001 C/A cg06521331 chr12:34319734 NA -0.46 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs2629540 0.765 rs12221075 chr10:126534855 G/A cg08799069 chr10:126477246 METTL10 -0.52 -7.78 -0.39 9.23e-14 Cocaine dependence; LUSC cis rs4713675 0.565 rs3818530 chr6:33661222 C/G cg14003231 chr6:33640908 ITPR3 0.31 6.1 0.32 2.97e-9 Plateletcrit; LUSC cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg21770322 chr7:97807741 LMTK2 0.55 10.04 0.48 6.79e-21 Breast cancer; LUSC cis rs500891 0.693 rs1013317 chr6:83979611 C/T cg08257003 chr6:84140564 ME1 0.34 7.03 0.36 1.18e-11 Platelet-derived growth factor BB levels; LUSC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg18876405 chr7:65276391 NA -0.55 -8.77 -0.43 9.11e-17 Aortic root size; LUSC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg18252515 chr7:66147081 NA 1.24 14.24 0.61 2.72e-36 Diabetic kidney disease; LUSC cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg18252515 chr7:66147081 NA -0.58 -7.99 -0.4 2.16e-14 Corneal structure; LUSC cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg06462663 chr19:18546047 ISYNA1 0.48 8.24 0.41 3.95e-15 Breast cancer; LUSC cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg13010199 chr12:38710504 ALG10B 0.66 9.98 0.48 1.02e-20 Bladder cancer; LUSC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg00149659 chr3:10157352 C3orf10 0.98 14.52 0.62 2.16e-37 Alzheimer's disease; LUSC cis rs7216064 0.906 rs78452260 chr17:65848522 G/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.4 -0.46 9.15e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg25456477 chr12:86230367 RASSF9 0.33 5.8 0.3 1.55e-8 Major depressive disorder; LUSC cis rs701145 0.585 rs1609205 chr3:153793923 G/A cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs10806425 0.524 rs1394220 chr6:91019304 A/C cg06866423 chr6:90926672 BACH2 0.41 6.6 0.34 1.63e-10 Celiac disease; LUSC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg25019033 chr10:957182 NA -0.52 -6.51 -0.34 2.81e-10 Eosinophil percentage of granulocytes; LUSC cis rs921968 0.643 rs711191 chr2:219386084 T/A cg02176678 chr2:219576539 TTLL4 0.64 11.6 0.54 2.25e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs72772090 0.539 rs11740375 chr5:96112897 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.67 -6.93 -0.35 2.24e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10911363 0.592 rs4047798 chr1:183421406 C/T cg09173681 chr1:183549694 NCF2 -0.62 -11.07 -0.52 1.84e-24 Systemic lupus erythematosus; LUSC trans rs8040855 0.965 rs4843027 chr15:85715123 G/A cg00988175 chr11:59481031 OR10V1 -0.3 -6.56 -0.34 2.02e-10 Bulimia nervosa; LUSC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg21862992 chr11:68658383 NA 0.51 8.09 0.4 1.11e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.0 -0.52 3.3e-24 Mean corpuscular volume; LUSC trans rs1493916 0.777 rs1845385 chr18:31318336 T/C cg27147174 chr7:100797783 AP1S1 -0.54 -8.49 -0.42 6.74e-16 Life satisfaction; LUSC cis rs56399783 0.901 rs73033407 chr7:2878857 G/C cg14895029 chr7:2775587 GNA12 0.57 6.42 0.33 4.64e-10 Childhood ear infection; LUSC cis rs35146811 0.735 rs2272345 chr7:99797031 C/G cg22906224 chr7:99728672 NA 0.47 6.58 0.34 1.86e-10 Coronary artery disease; LUSC cis rs7927771 0.560 rs4752858 chr11:47685829 C/T cg20307385 chr11:47447363 PSMC3 -0.43 -6.28 -0.33 1.04e-9 Subjective well-being; LUSC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg04553112 chr3:125709451 NA -0.48 -5.82 -0.3 1.41e-8 Blood pressure (smoking interaction); LUSC cis rs12908161 0.920 rs12904605 chr15:85201419 T/C cg12863693 chr15:85201151 NMB 0.41 8.54 0.42 4.82e-16 Schizophrenia; LUSC cis rs6430585 0.941 rs10496737 chr2:136540083 A/G cg07169764 chr2:136633963 MCM6 0.87 11.91 0.55 1.67e-27 Corneal structure; LUSC cis rs4363385 0.818 rs561143 chr1:153010734 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs3768617 0.811 rs10911233 chr1:183052585 G/A ch.1.3577855R chr1:183094577 LAMC1 0.61 8.75 0.43 1.08e-16 Fuchs's corneal dystrophy; LUSC trans rs11098499 0.954 rs10031483 chr4:120422636 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg14019146 chr3:50243930 SLC38A3 0.31 6.96 0.36 1.81e-11 Intelligence (multi-trait analysis); LUSC cis rs10193935 0.901 rs17029411 chr2:42479149 G/A cg27598129 chr2:42591480 NA -0.57 -7.82 -0.39 6.99e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs983392 0.709 rs11601689 chr11:59996266 G/C cg20284999 chr11:59952153 MS4A6A -0.37 -6.11 -0.32 2.85e-9 Alzheimer's disease (late onset); LUSC cis rs7705502 0.962 rs1976074 chr5:173384663 T/A cg18693985 chr5:173351052 CPEB4 -0.39 -6.23 -0.32 1.37e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg17911788 chr17:44343683 NA 0.29 5.68 0.3 2.98e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg16745616 chr19:8428856 ANGPTL4 -0.4 -6.02 -0.31 4.55e-9 HDL cholesterol; LUSC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg08499158 chr17:42289980 UBTF 0.4 6.21 0.32 1.59e-9 Total body bone mineral density; LUSC cis rs447735 0.587 rs11640702 chr16:89729169 A/G cg06640241 chr16:89574553 SPG7 -0.39 -5.71 -0.3 2.47e-8 Hemoglobin concentration; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg14893161 chr1:205819251 PM20D1 -0.87 -16.69 -0.67 6.72e-46 Menarche (age at onset); LUSC cis rs908922 0.651 rs7529157 chr1:152531365 C/A cg20991723 chr1:152506922 NA 0.49 9.19 0.45 4.2e-18 Hair morphology; LUSC cis rs11608355 1.000 rs11611370 chr12:109870291 A/G cg05360138 chr12:110035743 NA -0.45 -6.21 -0.32 1.54e-9 Neuroticism; LUSC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg06112835 chr11:68658793 MRPL21 0.52 7.88 0.4 4.61e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs3857536 0.813 rs7743965 chr6:66941346 C/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11890956 chr21:40555474 PSMG1 -0.73 -10.93 -0.51 5.52e-24 Menarche (age at onset); LUSC cis rs2540226 0.935 rs2716730 chr2:39955834 T/C cg23576258 chr2:39999331 THUMPD2 0.35 5.85 0.3 1.16e-8 Personality dimensions; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg23131131 chr22:24373011 LOC391322 -0.49 -7.1 -0.36 7.58e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs394563 0.591 rs805026 chr6:149728254 G/C cg11245181 chr6:149772854 ZC3H12D -0.29 -6.33 -0.33 7.91e-10 Dupuytren's disease; LUSC cis rs7100689 0.753 rs4934125 chr10:82147466 T/C cg01528321 chr10:82214614 TSPAN14 1.06 16.23 0.66 4.3e-44 Post bronchodilator FEV1; LUSC cis rs7937682 0.562 rs7938620 chr11:111366844 G/A cg09085632 chr11:111637200 PPP2R1B 0.5 6.97 0.36 1.67e-11 Primary sclerosing cholangitis; LUSC cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg26384229 chr12:38710491 ALG10B 0.88 15.08 0.64 1.52e-39 Bladder cancer; LUSC cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg23711669 chr6:146136114 FBXO30 0.87 16.14 0.66 9.98e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs734999 0.566 rs6664969 chr1:2534978 G/A cg18932078 chr1:2524107 MMEL1 0.32 7.14 0.36 5.89e-12 Ulcerative colitis; LUSC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC cis rs11864453 0.713 rs9926156 chr16:72142895 G/C cg01557791 chr16:72042693 DHODH -0.48 -7.08 -0.36 8.4e-12 Fibrinogen levels; LUSC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg02487422 chr3:49467188 NICN1 0.42 6.12 0.32 2.65e-9 Parkinson's disease; LUSC cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg16482183 chr6:26056742 HIST1H1C 0.55 7.91 0.4 3.9e-14 Height; LUSC cis rs9549260 0.599 rs12870023 chr13:41244222 T/A cg21288729 chr13:41239152 FOXO1 0.62 9.52 0.46 3.52e-19 Red blood cell count; LUSC cis rs34526934 0.566 rs9141 chr2:177037970 T/C cg26754761 chr2:177040938 NA -0.41 -7.96 -0.4 2.63e-14 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.2 0.66 5.64e-44 Platelet count; LUSC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg20283391 chr11:68216788 NA -0.57 -8.17 -0.41 6.57e-15 Total body bone mineral density; LUSC cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13012494 chr21:47604986 C21orf56 0.45 6.6 0.34 1.6e-10 Testicular germ cell tumor; LUSC cis rs4730250 0.554 rs76257331 chr7:106916279 G/A cg02696742 chr7:106810147 HBP1 -0.55 -7.4 -0.38 1.13e-12 Osteoarthritis; LUSC cis rs11098499 0.738 rs72918577 chr4:120326701 G/A cg24375607 chr4:120327624 NA 0.77 11.34 0.53 1.95e-25 Corneal astigmatism; LUSC cis rs912057 1.000 rs1294414 chr6:6740366 A/G cg06612196 chr6:6737390 NA 0.53 9.84 0.47 3.17e-20 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg20302533 chr7:39170763 POU6F2 0.53 8.32 0.41 2.29e-15 IgG glycosylation; LUSC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg12963246 chr6:28129442 ZNF389 0.52 7.12 0.36 6.72e-12 Depression; LUSC trans rs61931739 0.817 rs10743841 chr12:34252870 T/C cg26384229 chr12:38710491 ALG10B 0.56 9.07 0.44 1.06e-17 Morning vs. evening chronotype; LUSC cis rs28595532 1.000 rs11938970 chr4:119660152 A/G cg21605333 chr4:119757512 SEC24D 0.88 8.09 0.4 1.12e-14 Cannabis dependence symptom count; LUSC cis rs2237234 1.000 rs2237234 chr6:26391394 G/A cg09904177 chr6:26538194 HMGN4 -0.45 -6.07 -0.32 3.38e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg12257692 chr3:49977190 RBM6 -0.24 -6.57 -0.34 1.97e-10 Intelligence (multi-trait analysis); LUSC cis rs4820294 1.000 rs732856 chr22:38060691 C/G cg21798802 chr22:38057573 PDXP -0.49 -10.82 -0.51 1.38e-23 Fat distribution (HIV); LUSC cis rs7208859 0.573 rs8078656 chr17:29080971 A/T cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs16895831 0.519 rs62414629 chr6:42598898 G/A cg10605015 chr6:42532144 UBR2 -0.48 -5.69 -0.3 2.85e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg11632617 chr15:75315747 PPCDC -0.53 -6.9 -0.35 2.65e-11 Blood trace element (Zn levels); LUSC cis rs7124681 0.565 rs2203712 chr11:47534964 T/C cg20307385 chr11:47447363 PSMC3 0.44 6.45 0.33 4.04e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs703842 0.616 rs871871 chr12:58219681 G/A cg02175503 chr12:58329896 NA 0.4 5.73 0.3 2.27e-8 Multiple sclerosis; LUSC cis rs7267979 1.000 rs6050632 chr20:25432601 A/G cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg05872129 chr22:39784769 NA 0.59 10.39 0.49 4.27e-22 Intelligence (multi-trait analysis); LUSC trans rs2228479 0.850 rs2239358 chr16:89827330 C/G cg24644049 chr4:85504048 CDS1 0.88 7.56 0.38 3.9e-13 Skin colour saturation; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08228715 chr17:79895357 PYCR1 -0.45 -7.02 -0.36 1.22e-11 Electrocardiographic conduction measures; LUSC cis rs2439831 0.850 rs12440573 chr15:44108997 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.74 6.58 0.34 1.78e-10 Lung cancer in ever smokers; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg02679291 chr19:48248902 GLTSCR2 0.36 6.06 0.31 3.75e-9 Mosquito bite size; LUSC trans rs208520 0.690 rs864314 chr6:66814830 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.22 -25.58 -0.81 1.08e-80 Exhaled nitric oxide output; LUSC cis rs11158026 0.526 rs3783639 chr14:55348666 T/C cg04306507 chr14:55594613 LGALS3 0.4 6.45 0.33 3.94e-10 Parkinson's disease; LUSC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.02 0.36 1.25e-11 Parkinson's disease; LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg08470875 chr2:26401718 FAM59B 0.68 9.16 0.45 5.31e-18 Gut microbiome composition (summer); LUSC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg03576123 chr11:487126 PTDSS2 -0.45 -5.81 -0.3 1.45e-8 Systemic lupus erythematosus; LUSC cis rs11642862 1.000 rs11645367 chr16:30770074 C/T cg02466173 chr16:30829666 NA -0.71 -7.59 -0.38 3.31e-13 Tonsillectomy; LUSC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg08392591 chr16:89556376 ANKRD11 0.4 6.0 0.31 5.24e-9 Multiple myeloma (IgH translocation); LUSC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg09267113 chr7:98030324 BAIAP2L1 0.38 5.68 0.3 2.9e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg05985134 chr18:33552581 C18orf21 0.52 7.04 0.36 1.13e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs10779751 0.666 rs77270747 chr1:11214584 A/C cg08854313 chr1:11322531 MTOR -0.85 -13.21 -0.59 2.48e-32 Body mass index; LUSC cis rs2072499 0.767 rs3001789 chr1:156197614 T/G cg25208724 chr1:156163844 SLC25A44 1.04 21.37 0.76 1.86e-64 Testicular germ cell tumor; LUSC cis rs10843647 1.000 rs973483 chr12:30325893 T/G cg12718339 chr12:29936407 TMTC1 -0.35 -5.87 -0.31 1.03e-8 Glucose homeostasis traits; LUSC cis rs7267979 0.966 rs7270835 chr20:25435067 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.22 0.71 5.32e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7590368 0.706 rs56268818 chr2:10956011 C/T cg15705551 chr2:10952987 PDIA6 0.52 5.71 0.3 2.5e-8 Educational attainment (years of education); LUSC cis rs61935443 0.720 rs892493 chr12:95283943 T/C cg21533806 chr12:95267307 NA 0.51 6.35 0.33 7.08e-10 Schizophrenia; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg11060661 chr22:24314208 DDT;DDTL 0.47 7.32 0.37 1.83e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11992162 0.573 rs13264994 chr8:11782759 G/A cg14343924 chr8:8086146 FLJ10661 -0.45 -6.23 -0.32 1.43e-9 Monocyte count; LUSC cis rs4666002 0.956 rs13020949 chr2:27836605 C/T cg27432699 chr2:27873401 GPN1 0.41 5.82 0.3 1.35e-8 Phospholipid levels (plasma); LUSC cis rs11122272 0.735 rs2474623 chr1:231513993 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7267979 0.844 rs6050477 chr20:25221547 C/T cg13962466 chr20:25176127 ENTPD6 -0.38 -6.05 -0.31 3.85e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1448094 0.874 rs10779219 chr12:86322643 T/G cg00310523 chr12:86230176 RASSF9 0.4 7.18 0.37 4.67e-12 Major depressive disorder; LUSC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg04455712 chr21:45112962 RRP1B 0.43 8.14 0.41 7.98e-15 Mean corpuscular volume; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.28 0.45 2.23e-18 Prudent dietary pattern; LUSC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg05347473 chr6:146136440 FBXO30 0.63 10.93 0.51 5.81e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg10253484 chr15:75165896 SCAMP2 -0.5 -7.57 -0.38 3.59e-13 Breast cancer; LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg13047869 chr3:10149882 C3orf24 0.56 7.91 0.4 3.79e-14 Alzheimer's disease; LUSC cis rs12368653 0.666 rs1050045 chr12:58115271 A/G cg18357645 chr12:58087776 OS9 0.38 5.77 0.3 1.85e-8 Multiple sclerosis; LUSC cis rs477692 0.544 rs7923750 chr10:131446895 G/C cg05714579 chr10:131428358 MGMT -0.77 -11.67 -0.54 1.23e-26 Response to temozolomide; LUSC cis rs7202877 0.706 rs247437 chr16:75431275 T/G cg04384234 chr16:75411784 CFDP1 0.67 9.53 0.46 3.35e-19 Type 2 diabetes;Type 1 diabetes; LUSC cis rs709400 0.859 rs7154948 chr14:104022944 C/T cg24130564 chr14:104152367 KLC1 -0.49 -7.07 -0.36 9.18e-12 Body mass index; LUSC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg08219700 chr8:58056026 NA 0.43 5.68 0.3 2.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs2346177 0.519 rs1597040 chr2:46673903 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.58 -8.99 -0.44 1.92e-17 HDL cholesterol; LUSC cis rs9926296 0.609 rs4785710 chr16:89796756 C/T cg04287289 chr16:89883240 FANCA -0.5 -7.56 -0.38 3.85e-13 Vitiligo; LUSC cis rs8141529 0.753 rs5752813 chr22:29226570 T/G cg02153584 chr22:29168773 CCDC117 0.65 10.32 0.49 7.39e-22 Lymphocyte counts; LUSC cis rs7582180 0.629 rs4851296 chr2:100949570 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.28 -0.41 3.01e-15 Intelligence (multi-trait analysis); LUSC cis rs10843647 1.000 rs5010726 chr12:30337487 C/T cg12718339 chr12:29936407 TMTC1 0.35 5.77 0.3 1.84e-8 Glucose homeostasis traits; LUSC cis rs11605924 0.692 rs877412 chr11:45897651 A/C ch.11.939596F chr11:45881766 CRY2 0.66 10.13 0.48 3.24e-21 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg08999081 chr20:33150536 PIGU 0.52 10.26 0.49 1.2e-21 Glomerular filtration rate (creatinine); LUSC cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg13010199 chr12:38710504 ALG10B 0.71 10.85 0.51 1.03e-23 Bladder cancer; LUSC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg16362232 chr11:430036 ANO9 0.61 7.76 0.39 1.03e-13 Body mass index; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg18263451 chr1:25573180 C1orf63 0.41 6.07 0.32 3.51e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7829975 0.681 rs2271342 chr8:8643938 C/T cg17143192 chr8:8559678 CLDN23 0.39 6.06 0.31 3.71e-9 Mood instability; LUSC cis rs16949788 1.000 rs75532475 chr15:66832466 A/G cg08120210 chr15:66682733 MAP2K1 -0.61 -6.28 -0.33 1.04e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs614226 1.000 rs580016 chr12:120933977 T/C cg21053147 chr12:120880522 NA 0.51 6.2 0.32 1.65e-9 Type 1 diabetes nephropathy; LUSC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg11663144 chr21:46675770 NA -0.41 -7.12 -0.36 6.84e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs796364 0.951 rs11897245 chr2:201063644 A/G cg23649088 chr2:200775458 C2orf69 0.48 6.69 0.34 9.49e-11 Schizophrenia; LUSC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs7818345 0.637 rs3923920 chr8:19359184 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.3 -5.65 -0.3 3.4e-8 Language performance in older adults (adjusted for episodic memory); LUSC cis rs473651 0.904 rs508274 chr2:239337723 G/A cg08773314 chr2:239334832 ASB1 0.42 9.26 0.45 2.63e-18 Multiple system atrophy; LUSC cis rs35146811 0.735 rs11767968 chr7:99790971 G/A cg13334819 chr7:99746414 C7orf59 -0.5 -6.73 -0.35 7.41e-11 Coronary artery disease; LUSC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg14196790 chr5:131705035 SLC22A5 0.45 7.38 0.37 1.24e-12 Breast cancer;Mosquito bite size; LUSC cis rs4285028 0.747 rs11928871 chr3:121483388 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.24 -0.56 1.03e-28 Multiple sclerosis; LUSC cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg26395211 chr5:140044315 WDR55 0.46 7.13 0.36 6.16e-12 Depressive symptoms (multi-trait analysis); LUSC trans rs79976124 0.800 rs10944857 chr6:66637078 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 8.49 0.42 7.01e-16 Type 2 diabetes; LUSC cis rs4144743 1.000 rs34492688 chr17:45321622 C/A cg18085866 chr17:45331354 ITGB3 -0.75 -8.11 -0.41 9.69e-15 Body mass index; LUSC cis rs12545109 0.800 rs1837614 chr8:57414497 T/A cg09654669 chr8:57350985 NA -0.57 -7.83 -0.39 6.46e-14 Obesity-related traits; LUSC cis rs868036 0.915 rs4489954 chr15:68072075 A/C cg08079166 chr15:68083412 MAP2K5 -0.47 -9.87 -0.48 2.57e-20 Restless legs syndrome; LUSC cis rs78456975 1.000 rs4073861 chr2:1563611 G/A cg01028140 chr2:1542097 TPO -0.61 -8.28 -0.41 2.9e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg08085267 chr17:45401833 C17orf57 -0.54 -8.15 -0.41 7.21e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg20684491 chr1:25596433 NA 0.4 6.28 0.33 1.04e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg26338869 chr17:61819248 STRADA 0.41 5.95 0.31 6.66e-9 Prudent dietary pattern; LUSC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg12386194 chr3:101231763 SENP7 0.64 8.95 0.44 2.44e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg24562669 chr7:97807699 LMTK2 0.34 5.93 0.31 7.39e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs735539 0.645 rs7326068 chr13:21209512 A/G cg04906043 chr13:21280425 IL17D 0.37 6.16 0.32 2.11e-9 Dental caries; LUSC cis rs9811920 0.535 rs704574 chr3:99483773 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.3 5.84 0.3 1.27e-8 Axial length; LUSC cis rs9326248 0.769 rs499910 chr11:116763034 G/A cg20608306 chr11:116969690 SIK3 0.39 6.36 0.33 6.76e-10 Blood protein levels; LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg13628971 chr7:2884303 GNA12 0.48 6.69 0.34 9.7e-11 Height; LUSC cis rs7589342 0.831 rs10169998 chr2:106452253 A/G cg14210321 chr2:106509881 NCK2 -0.54 -8.06 -0.4 1.38e-14 Addiction; LUSC cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.73 0.35 7.39e-11 Tonsillectomy; LUSC cis rs7107174 1.000 rs9651768 chr11:77996020 C/T cg02023728 chr11:77925099 USP35 0.47 6.97 0.36 1.68e-11 Testicular germ cell tumor; LUSC cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg09184832 chr6:79620586 NA -0.44 -7.2 -0.37 3.94e-12 Intelligence (multi-trait analysis); LUSC trans rs72792513 1.000 rs72798597 chr2:22909794 C/T cg05844895 chr16:88969569 CBFA2T3 0.53 6.22 0.32 1.52e-9 Hepatitis B; LUSC trans rs9291683 0.551 rs2276961 chr4:10022981 C/T cg26043149 chr18:55253948 FECH 0.51 7.55 0.38 4.18e-13 Bone mineral density; LUSC cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg11102782 chr19:18549136 ISYNA1 -0.36 -6.89 -0.35 2.82e-11 Breast cancer; LUSC cis rs939658 0.805 rs8024813 chr15:79427260 A/G cg17916960 chr15:79447300 NA -0.53 -10.55 -0.5 1.22e-22 Refractive error; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02475777 chr4:1388615 CRIPAK 0.58 8.94 0.44 2.74e-17 Longevity; LUSC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg22508957 chr16:3507546 NAT15 0.65 10.86 0.51 9.8599999999999993e-24 Tuberculosis; LUSC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg20243544 chr17:37824526 PNMT 0.52 7.4 0.38 1.12e-12 Asthma; LUSC cis rs11190604 1.000 rs2273694 chr10:102256496 G/T cg23241863 chr10:102295624 HIF1AN 0.46 5.85 0.3 1.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10207060 0.500 rs4365487 chr2:240706803 T/C cg07506560 chr2:240697449 NA 0.45 6.92 0.35 2.34e-11 Obesity-related traits; LUSC cis rs983392 0.667 rs583791 chr11:59947252 C/T cg24026212 chr11:59952134 MS4A6A 0.34 6.23 0.32 1.43e-9 Alzheimer's disease (late onset); LUSC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg17366294 chr4:99064904 C4orf37 0.54 8.89 0.44 3.93e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg00012203 chr2:219082015 ARPC2 -0.76 -13.09 -0.58 6.86e-32 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg27165867 chr14:105738592 BRF1 -0.55 -8.03 -0.4 1.7e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs8114671 0.527 rs3736802 chr20:33604042 T/C cg24642439 chr20:33292090 TP53INP2 -0.47 -6.85 -0.35 3.54e-11 Height; LUSC cis rs13006833 0.668 rs906916 chr2:191166212 G/A cg21644426 chr2:191273491 MFSD6 0.43 6.27 0.32 1.09e-9 Urinary metabolites; LUSC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg14416269 chr4:6271139 WFS1 -0.53 -11.37 -0.53 1.47e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9372253 1.000 rs9374170 chr6:110712991 A/G cg01119278 chr6:110721349 DDO -0.45 -7.96 -0.4 2.62e-14 Platelet distribution width; LUSC cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg00339695 chr16:24857497 SLC5A11 0.39 6.72 0.34 8.02e-11 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.64 -13.55 -0.6 1.18e-33 Monocyte percentage of white cells; LUSC trans rs6076960 0.682 rs6054065 chr20:6267920 G/A cg21095983 chr6:86352623 SYNCRIP 0.53 8.47 0.42 7.8e-16 Smooth-surface caries; LUSC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.25 -0.32 1.23e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg26142380 chr17:27276017 PHF12 0.44 6.05 0.31 3.83e-9 Neuroticism; LUSC cis rs67981189 0.593 rs9323557 chr14:71470840 C/T cg15816911 chr14:71606274 NA -0.37 -6.52 -0.34 2.58e-10 Schizophrenia; LUSC cis rs847577 1.000 rs847577 chr7:97694858 T/A cg21770322 chr7:97807741 LMTK2 -0.51 -9.16 -0.45 5.3e-18 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02185053 chr8:130952137 FAM49B -0.43 -6.55 -0.34 2.13e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 12.93 0.58 2.8e-31 Chronic sinus infection; LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg20406979 chr6:167373233 NA 0.26 6.24 0.32 1.34e-9 Crohn's disease; LUSC cis rs11051970 0.877 rs2651360 chr12:32588920 C/T cg02745156 chr12:32552066 NA 0.43 7.3 0.37 2.16e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg03264133 chr6:25882463 NA 0.39 6.37 0.33 6.29e-10 Intelligence (multi-trait analysis); LUSC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg14552801 chr7:65878734 NA 0.38 5.9 0.31 8.97e-9 Aortic root size; LUSC cis rs2625529 0.617 rs62023343 chr15:72174963 C/A cg16672083 chr15:72433130 SENP8 0.48 7.93 0.4 3.38e-14 Red blood cell count; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg22963979 chr7:1858916 MAD1L1 -0.56 -8.71 -0.43 1.4e-16 Bipolar disorder and schizophrenia; LUSC cis rs73198271 0.562 rs112717383 chr8:8663216 T/C cg01851573 chr8:8652454 MFHAS1 0.62 7.89 0.4 4.28e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg05025164 chr4:1340916 KIAA1530 0.63 9.61 0.47 1.77e-19 Longevity; LUSC cis rs2073300 1.000 rs6036418 chr20:23449698 A/G cg09953122 chr20:23471693 CST8 -0.64 -5.83 -0.3 1.3e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3808502 0.549 rs1382563 chr8:11426790 C/G cg21775007 chr8:11205619 TDH 0.51 7.47 0.38 6.97e-13 Neuroticism; LUSC trans rs372883 0.648 rs1003772 chr21:30736145 A/T cg14791747 chr16:20752902 THUMPD1 -0.44 -6.17 -0.32 1.92e-9 Pancreatic cancer; LUSC cis rs7131987 0.874 rs10843366 chr12:29407903 T/C cg09582351 chr12:29534625 ERGIC2 -0.32 -6.62 -0.34 1.39e-10 QT interval; LUSC trans rs997154 0.655 rs7147394 chr14:23411054 C/G cg08043656 chr13:52419383 FLJ37307 0.42 6.01 0.31 4.83e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); LUSC cis rs897984 0.568 rs4889653 chr16:30895713 C/T cg02466173 chr16:30829666 NA 0.51 8.48 0.42 7.29e-16 Dementia with Lewy bodies; LUSC cis rs9815354 0.812 rs73083333 chr3:41927505 G/A cg03022575 chr3:42003672 ULK4 0.82 8.8 0.43 7.29e-17 Pulse pressure;Diastolic blood pressure; LUSC trans rs9951602 0.512 rs4799244 chr18:76649763 T/C cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC trans rs4811340 0.600 rs6063829 chr20:51173570 G/A cg15736553 chr3:11610338 VGLL4 -0.34 -6.06 -0.31 3.74e-9 Thyroid peroxidase antibody positivity; LUSC cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg12011299 chr4:100065546 ADH4 0.62 9.83 0.47 3.52e-20 Alcohol dependence; LUSC cis rs9296092 0.517 rs6911036 chr6:33471652 C/G cg13560919 chr6:33536144 NA -0.78 -13.33 -0.59 8.65e-33 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.5 0.34 2.94e-10 Lung cancer; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg04234412 chr22:24373322 LOC391322 0.78 11.85 0.54 2.76e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg23711669 chr6:146136114 FBXO30 -0.74 -13.04 -0.58 1.02e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs983392 0.667 rs624663 chr11:59945065 C/T cg20284999 chr11:59952153 MS4A6A 0.35 6.08 0.32 3.34e-9 Alzheimer's disease (late onset); LUSC cis rs10465746 0.725 rs980417 chr1:84365331 C/A cg10977910 chr1:84465055 TTLL7 0.51 7.29 0.37 2.21e-12 Obesity-related traits; LUSC cis rs796364 0.512 rs1653290 chr2:201078165 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.63 7.39 0.37 1.18e-12 Schizophrenia; LUSC cis rs2404602 0.692 rs7163397 chr15:76940315 A/G cg26408565 chr15:76604113 ETFA -0.47 -7.42 -0.38 9.75e-13 Blood metabolite levels; LUSC cis rs4478037 0.822 rs9868526 chr3:33124269 A/G cg19404215 chr3:33155277 CRTAP -0.8 -9.34 -0.46 1.4e-18 Major depressive disorder; LUSC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08704250 chr15:31115839 NA 0.39 6.12 0.32 2.68e-9 Huntington's disease progression; LUSC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg11752832 chr7:134001865 SLC35B4 0.55 8.61 0.43 2.94e-16 Mean platelet volume; LUSC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg05855489 chr10:104503620 C10orf26 -0.71 -10.46 -0.5 2.47e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg18225595 chr11:63971243 STIP1 0.49 6.08 0.32 3.24e-9 Mean platelet volume; LUSC cis rs4938330 0.512 rs4938327 chr11:116906728 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.65 -0.34 1.17e-10 Blood protein levels; LUSC cis rs941408 0.515 rs12610096 chr19:2778129 C/T cg06609049 chr19:2785107 THOP1 1.14 22.08 0.77 2.89e-67 Total cholesterol levels; LUSC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg02931644 chr1:25747376 RHCE 0.35 6.41 0.33 5.01e-10 Plateletcrit;Mean corpuscular volume; LUSC cis rs8017423 0.935 rs3742668 chr14:90767759 G/A cg04374321 chr14:90722782 PSMC1 -0.67 -10.23 -0.49 1.52e-21 Mortality in heart failure; LUSC cis rs909674 0.734 rs1005522 chr22:39845898 C/A cg05872129 chr22:39784769 NA -0.52 -8.03 -0.4 1.65e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs8030485 0.756 rs2102999 chr15:79410710 C/T cg17916960 chr15:79447300 NA -0.37 -6.66 -0.34 1.15e-10 Left ventricle wall thickness; LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg24675658 chr1:53192096 ZYG11B -0.67 -11.08 -0.52 1.7e-24 Monocyte count; LUSC cis rs7954584 0.616 rs10743185 chr12:122356435 G/A cg10207240 chr12:122356781 WDR66 0.44 6.16 0.32 2.05e-9 Mean corpuscular volume; LUSC cis rs9527 0.590 rs6584537 chr10:104778267 C/G cg05855489 chr10:104503620 C10orf26 0.53 8.11 0.41 9.87e-15 Arsenic metabolism; LUSC cis rs9583531 0.891 rs7999536 chr13:111382199 G/A cg24331049 chr13:111365604 ING1 0.65 7.37 0.37 1.37e-12 Coronary artery disease; LUSC cis rs35146811 0.624 rs1727134 chr7:99813672 T/C cg13334819 chr7:99746414 C7orf59 0.5 6.71 0.34 8.38e-11 Coronary artery disease; LUSC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.66 14.89 0.63 8.34e-39 Hemoglobin concentration; LUSC cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg10802521 chr3:52805072 NEK4 -0.53 -8.56 -0.42 4.11e-16 Bipolar disorder; LUSC cis rs7829975 0.626 rs332040 chr8:8730488 G/A cg08975724 chr8:8085496 FLJ10661 0.56 8.22 0.41 4.65e-15 Mood instability; LUSC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg07741184 chr6:167504864 NA -0.39 -6.93 -0.35 2.22e-11 Crohn's disease; LUSC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg09640425 chr7:158790006 NA -0.52 -8.2 -0.41 5.4e-15 Facial morphology (factor 20); LUSC cis rs7617480 0.648 rs9859473 chr3:48837182 A/G cg07636037 chr3:49044803 WDR6 0.88 12.15 0.55 2.15e-28 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg14830002 chr1:247616686 OR2B11 0.49 7.05 0.36 1.05e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg07677032 chr17:61819896 STRADA 0.52 8.77 0.43 9e-17 Prudent dietary pattern; LUSC cis rs709400 0.894 rs10143293 chr14:104063014 G/A cg24130564 chr14:104152367 KLC1 -0.48 -6.87 -0.35 3.19e-11 Body mass index; LUSC cis rs2404618 0.593 rs7829532 chr8:1485190 C/A cg02903104 chr8:1507517 DLGAP2 0.35 6.8 0.35 4.87e-11 Lung cancer; LUSC trans rs877282 1.000 rs34257857 chr10:772993 C/A cg13042288 chr15:90349979 ANPEP -0.48 -6.91 -0.35 2.46e-11 Uric acid levels; LUSC cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg04362960 chr10:104952993 NT5C2 0.66 9.45 0.46 6.02e-19 Arsenic metabolism; LUSC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg04414720 chr1:150670196 GOLPH3L 0.56 8.94 0.44 2.78e-17 Urate levels; LUSC cis rs5769707 0.872 rs5770604 chr22:50030672 G/A cg10356904 chr22:49881777 NA -0.3 -6.76 -0.35 6.13e-11 Monocyte count;Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07051718 chr19:1438596 RPS15 0.43 6.03 0.31 4.37e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7267979 1.000 rs2500436 chr20:25406366 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.78 -0.7 2.97e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4443100 1.000 rs4443100 chr22:23372864 C/G cg21100191 chr22:23484243 RTDR1 0.5 6.1 0.32 3e-9 Serum parathyroid hormone levels; LUSC trans rs629535 0.773 rs681534 chr8:70056964 A/C cg21567404 chr3:27674614 NA 0.97 15.56 0.65 1.96e-41 Dupuytren's disease; LUSC cis rs2806561 0.765 rs4333826 chr1:23517514 C/T cg19743168 chr1:23544995 NA 0.4 7.89 0.4 4.25e-14 Height; LUSC cis rs813218 0.625 rs793484 chr3:99491508 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.3 -5.7 -0.3 2.58e-8 Orofacial clefts; LUSC cis rs7315438 0.600 rs1874894 chr12:115886306 C/T cg24172291 chr12:115889509 NA -0.36 -6.14 -0.32 2.36e-9 Colorectal cancer; LUSC cis rs8180040 0.966 rs3816779 chr3:47543389 C/T cg02527881 chr3:46936655 PTH1R -0.38 -6.66 -0.34 1.1e-10 Colorectal cancer; LUSC cis rs9796 0.505 rs28665387 chr15:41532869 G/T cg18705301 chr15:41695430 NDUFAF1 -0.49 -8.57 -0.42 3.98e-16 Menopause (age at onset); LUSC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg18350739 chr11:68623251 NA -0.39 -6.8 -0.35 4.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.82e-23 Homoarginine levels; LUSC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg24675056 chr1:15929824 NA 0.49 8.5 0.42 6.3e-16 Systolic blood pressure; LUSC cis rs617219 0.889 rs12659618 chr5:78465660 G/A cg24856658 chr5:78533917 JMY -0.3 -5.75 -0.3 1.98e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.59 8.72 0.43 1.36e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg02782426 chr3:40428986 ENTPD3 -0.39 -7.61 -0.38 2.76e-13 Renal cell carcinoma; LUSC cis rs9653442 0.675 rs2871326 chr2:100662010 T/C cg22139774 chr2:100720529 AFF3 -0.47 -8.12 -0.41 9.11e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs10946292 0.706 rs3013256 chr6:170434737 C/G cg17832364 chr10:94847294 NA 0.39 6.45 0.33 3.95e-10 Obesity-related traits; LUSC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.62 13.12 0.58 5.47e-32 Monocyte percentage of white cells; LUSC cis rs9309473 0.950 rs6546854 chr2:73834034 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.42 -0.33 4.75e-10 Metabolite levels; LUSC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg11764359 chr7:65958608 NA -0.51 -6.57 -0.34 1.94e-10 Aortic root size; LUSC trans rs1997103 0.954 rs6593222 chr7:55372932 A/C cg20935933 chr6:143382018 AIG1 0.5 7.08 0.36 8.38e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs12101261 0.536 rs724170 chr14:81457940 G/A cg06600135 chr14:81408086 NA 0.46 6.96 0.36 1.79e-11 Graves' disease; LUSC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs7917772 0.582 rs10883738 chr10:104321721 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.86 0.51 9.5e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg03060546 chr3:49711283 APEH 0.72 12.18 0.55 1.79e-28 Resting heart rate; LUSC cis rs1729951 0.575 rs361244 chr3:136697506 C/T cg12473912 chr3:136751656 NA 0.39 6.82 0.35 4.24e-11 Neuroticism; LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg16325326 chr1:53192061 ZYG11B 0.7 11.44 0.53 8.58e-26 Monocyte count; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.56 0.34 2.09e-10 Menopause (age at onset); LUSC cis rs67460515 0.563 rs4679672 chr3:160901020 G/A cg03342759 chr3:160939853 NMD3 -0.44 -6.31 -0.33 8.8e-10 Parkinson's disease; LUSC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg20607287 chr7:12443886 VWDE -0.58 -6.03 -0.31 4.37e-9 Coronary artery disease; LUSC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg13114125 chr14:105738426 BRF1 -0.95 -16.13 -0.66 1.07e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs861020 1.000 rs7555285 chr1:209970355 C/G cg05527609 chr1:210001259 C1orf107 -0.8 -10.07 -0.48 5.22e-21 Orofacial clefts; LUSC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg00033643 chr7:134001901 SLC35B4 0.46 7.28 0.37 2.44e-12 Mean platelet volume; LUSC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg22875332 chr1:76189707 ACADM 0.82 13.97 0.61 3.12e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1670533 1.000 rs2100411 chr4:1074412 T/C cg02018176 chr4:1364513 KIAA1530 0.46 6.53 0.34 2.46e-10 Recombination rate (females); LUSC cis rs1728785 0.818 rs1069289 chr16:68585317 C/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.73 -0.3 2.23e-8 Ulcerative colitis; LUSC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg20203395 chr5:56204925 C5orf35 -0.75 -10.17 -0.49 2.51e-21 Initial pursuit acceleration; LUSC cis rs11864453 0.826 rs2072142 chr16:72132713 C/T cg16558253 chr16:72132732 DHX38 -0.41 -6.32 -0.33 8.5e-10 Fibrinogen levels; LUSC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg23093090 chr10:104574429 C10orf26 -0.45 -8.06 -0.4 1.37e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6693567 0.565 rs7544900 chr1:150262333 A/C cg15654264 chr1:150340011 RPRD2 -0.45 -7.29 -0.37 2.25e-12 Migraine; LUSC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg09655341 chr17:79618100 PDE6G -0.29 -6.64 -0.34 1.29e-10 Eye color traits; LUSC cis rs11997175 0.646 rs4733177 chr8:33691754 A/G ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.21e-10 Body mass index; LUSC cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg12432903 chr7:1882776 MAD1L1 0.52 6.32 0.33 8.26e-10 Bipolar disorder; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg23978390 chr7:1156363 C7orf50 0.44 6.25 0.32 1.25e-9 Longevity;Endometriosis; LUSC cis rs607541 0.764 rs629466 chr15:45934745 A/T cg26924012 chr15:45694286 SPATA5L1 0.55 5.86 0.31 1.1e-8 Obesity-related traits; LUSC cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs796364 0.806 rs11691873 chr2:200966337 A/G cg23649088 chr2:200775458 C2orf69 -0.53 -6.46 -0.33 3.79e-10 Schizophrenia; LUSC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.12 0.52 1.15e-24 Menopause (age at onset); LUSC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg10792982 chr14:105748885 BRF1 -0.45 -8.04 -0.4 1.52e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg09085632 chr11:111637200 PPP2R1B -1.07 -17.06 -0.68 2.23e-47 Primary sclerosing cholangitis; LUSC cis rs2742234 0.541 rs1879310 chr10:43734775 A/G cg07801480 chr10:43725741 RASGEF1A -0.39 -5.91 -0.31 8.49e-9 Hirschsprung disease; LUSC cis rs8060686 0.623 rs56303487 chr16:68029739 C/T cg26727032 chr16:67993705 SLC12A4 -0.45 -6.75 -0.35 6.58e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.0 0.52 3.27e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs17621444 0.522 rs4752366 chr10:121763304 G/A cg02041677 chr10:121771263 NA -0.33 -6.23 -0.32 1.4e-9 IgG glycosylation; LUSC cis rs2991971 1.000 rs2991972 chr1:46013208 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.41 -0.33 4.92e-10 High light scatter reticulocyte count; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.28 0.56 7.31e-29 Prudent dietary pattern; LUSC trans rs11992162 0.551 rs59191504 chr8:11785081 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.71 -0.34 8.22e-11 Monocyte count; LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.54 -9.55 -0.46 2.87e-19 Bipolar disorder; LUSC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg04455712 chr21:45112962 RRP1B 0.45 8.42 0.42 1.15e-15 Mean corpuscular volume; LUSC trans rs208515 0.556 rs12214562 chr6:66681011 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.18 0.61 4.72e-36 Exhaled nitric oxide levels; LUSC trans rs72674100 1.000 rs4145376 chr4:97994304 C/T cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3806843 1.000 rs4151682 chr5:140201264 C/T cg19875535 chr5:140030758 IK 0.46 7.32 0.37 1.91e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs1448094 0.967 rs11117116 chr12:86331087 A/T cg18827107 chr12:86230957 RASSF9 -0.41 -5.99 -0.31 5.43e-9 Major depressive disorder; LUSC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.18e-11 Testicular germ cell tumor; LUSC cis rs9921338 0.961 rs17605444 chr16:11413589 A/C cg00044050 chr16:11439710 C16orf75 -0.52 -7.13 -0.36 6.41e-12 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs870825 0.929 rs72689254 chr4:185589941 C/T cg04058563 chr4:185651563 MLF1IP 0.81 10.69 0.5 3.94e-23 Blood protein levels; LUSC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg06108461 chr20:60628389 TAF4 -1.01 -17.53 -0.69 3.14e-49 Body mass index; LUSC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg10802521 chr3:52805072 NEK4 -0.53 -8.53 -0.42 5.07e-16 Bipolar disorder; LUSC cis rs983392 0.803 rs56189574 chr11:59933492 A/G cg24026212 chr11:59952134 MS4A6A -0.36 -6.36 -0.33 6.81e-10 Alzheimer's disease (late onset); LUSC cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.86 0.4 5.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1997103 0.954 rs6593236 chr7:55410992 C/T cg17469321 chr7:55412551 NA 0.66 10.59 0.5 8.59e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg26354017 chr1:205819088 PM20D1 0.85 15.21 0.64 4.58e-40 Menarche (age at onset); LUSC cis rs10193935 1.000 rs13424523 chr2:42413562 T/G cg27598129 chr2:42591480 NA -0.61 -8.05 -0.4 1.48e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs8133932 0.564 rs452797 chr21:47348455 C/G cg14185626 chr21:47401492 COL6A1 -0.44 -5.65 -0.3 3.37e-8 Schizophrenia; LUSC cis rs79057730 0.684 rs6955004 chr7:790792 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.53 0.34 2.44e-10 Initial pursuit acceleration; LUSC cis rs7089973 0.604 rs11196941 chr10:116596258 A/G cg03647239 chr10:116582469 FAM160B1 0.45 7.24 0.37 3.04e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7909074 0.714 rs10900129 chr10:45398609 G/C cg05187965 chr10:45406764 TMEM72 -0.31 -6.79 -0.35 5.2e-11 Mean corpuscular volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18009376 chr17:80056900 FASN -0.41 -5.98 -0.31 5.88e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6669072 0.679 rs1766163 chr1:91314510 C/T cg08895590 chr1:91227319 NA -0.32 -6.83 -0.35 4.06e-11 Cognitive function; LUSC cis rs2014572 0.510 rs8111661 chr19:57752326 C/G cg12963866 chr19:57752005 ZNF805 0.41 5.87 0.31 1.08e-8 Hyperactive-impulsive symptoms; LUSC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg24829409 chr8:58192753 C8orf71 -0.49 -5.69 -0.3 2.78e-8 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.966 rs2482948 chr20:25296499 T/C cg03522245 chr20:25566470 NINL -0.36 -5.83 -0.3 1.33e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3862435 0.706 rs2525999 chr15:90970571 A/G cg22089800 chr15:90895588 ZNF774 0.58 6.24 0.32 1.3e-9 Response to exercise (triglyceride level interaction); LUSC cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg11530693 chr1:120165357 ZNF697 0.69 11.07 0.52 1.75e-24 Systemic lupus erythematosus; LUSC cis rs7572644 0.629 rs28662360 chr2:28208920 A/G cg27432699 chr2:27873401 GPN1 -0.51 -6.86 -0.35 3.28e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.96 0.44 2.42e-17 Schizophrenia; LUSC cis rs1190552 0.846 rs12883789 chr14:102954621 G/A cg18135206 chr14:102964638 TECPR2 0.46 5.69 0.3 2.73e-8 Blood protein levels; LUSC cis rs7666738 0.546 rs10026181 chr4:98814118 C/T cg05340658 chr4:99064831 C4orf37 -0.57 -8.44 -0.42 9.6e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.89 0.4 4.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4660306 0.961 rs7539253 chr1:45947420 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -7.09 -0.36 7.98e-12 Homocysteine levels; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg14159672 chr1:205819179 PM20D1 0.98 21.07 0.76 2.68e-63 Menarche (age at onset); LUSC cis rs6840360 1.000 rs1366909 chr4:152588421 A/C cg22705602 chr4:152727874 NA -0.27 -5.79 -0.3 1.63e-8 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg26335602 chr6:28129616 ZNF389 0.46 6.3 0.33 9.21e-10 Depression; LUSC cis rs9427116 0.702 rs9427108 chr1:154607914 G/A cg17218026 chr1:154582156 ADAR 0.56 9.92 0.48 1.69e-20 Blood protein levels; LUSC trans rs61931739 0.635 rs1852225 chr12:33963004 C/T cg13010199 chr12:38710504 ALG10B 0.4 6.03 0.31 4.38e-9 Morning vs. evening chronotype; LUSC cis rs9611565 0.649 rs139540 chr22:42178040 C/T cg17376030 chr22:41985996 PMM1 0.43 5.67 0.3 3.06e-8 Vitiligo; LUSC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg27432699 chr2:27873401 GPN1 -0.48 -7.09 -0.36 7.82e-12 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs977987 0.806 rs7188231 chr16:75436561 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.04 -0.36 1.08e-11 Dupuytren's disease; LUSC cis rs9905704 0.718 rs8072379 chr17:56615997 C/A cg19466818 chr17:56409534 MIR142 0.35 6.54 0.34 2.31e-10 Testicular germ cell tumor; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23415442 chr10:88855540 GLUD1;FAM35A 0.46 6.26 0.32 1.16e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg05890377 chr2:74357713 NA -0.68 -12.63 -0.57 3.75e-30 Gestational age at birth (maternal effect); LUSC cis rs11614062 1.000 rs11614062 chr12:93956672 A/T cg18151635 chr12:93972918 NA -0.58 -7.8 -0.39 7.79e-14 Height; LUSC cis rs300703 0.935 rs300749 chr2:208143 G/T cg21211680 chr2:198530 NA 0.68 7.31 0.37 2e-12 Blood protein levels; LUSC cis rs9640161 0.830 rs17173702 chr7:150068605 G/A cg10018233 chr7:150070692 REPIN1 0.4 7.11 0.36 6.9e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs1577917 0.665 rs4304137 chr6:86217448 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 10.57 0.5 9.82e-23 Response to antipsychotic treatment; LUSC cis rs909002 0.800 rs968335 chr1:32085776 G/A cg01639898 chr1:32083012 HCRTR1 0.31 7.5 0.38 5.73e-13 Intelligence (multi-trait analysis); LUSC cis rs977987 0.872 rs1559339 chr16:75318646 A/G cg03315344 chr16:75512273 CHST6 0.5 9.61 0.47 1.86e-19 Dupuytren's disease; LUSC trans rs867371 1.000 rs13380317 chr15:82506790 A/G cg04831495 chr15:85060580 GOLGA6L5 0.37 6.1 0.32 3e-9 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs8060686 0.565 rs8044328 chr16:68146859 G/C cg27539214 chr16:67997921 SLC12A4 -0.55 -7.56 -0.38 3.86e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.68 10.47 0.5 2.29e-22 Hip circumference adjusted for BMI; LUSC cis rs701145 0.585 rs62276841 chr3:153783645 C/T cg17054900 chr3:154042577 DHX36 -0.73 -7.44 -0.38 8.72e-13 Coronary artery disease; LUSC cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg21918786 chr6:109611834 NA -0.38 -6.51 -0.34 2.78e-10 Reticulocyte fraction of red cells; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg24846343 chr22:24311635 DDTL -0.76 -17.13 -0.68 1.19e-47 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10743315 0.778 rs1586843 chr12:19354550 T/C cg02471346 chr12:19282374 PLEKHA5 -0.46 -5.83 -0.3 1.33e-8 Gut microbiota (bacterial taxa); LUSC cis rs4889855 0.585 rs72855201 chr17:78530597 A/G cg16591659 chr17:78472290 NA 0.32 5.9 0.31 9.14e-9 Fractional excretion of uric acid; LUSC cis rs354225 0.544 rs10169954 chr2:54808117 C/G cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg08859206 chr1:53392774 SCP2 -0.52 -8.94 -0.44 2.75e-17 Monocyte count; LUSC cis rs4964805 0.657 rs4964814 chr12:104189384 A/C cg02344784 chr12:104178138 NT5DC3 -0.44 -8.58 -0.42 3.66e-16 Attention deficit hyperactivity disorder; LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.89 -13.72 -0.6 2.82e-34 Platelet count; LUSC trans rs11165623 0.602 rs7517055 chr1:97007781 C/G cg10631902 chr5:14652156 NA -0.42 -6.41 -0.33 4.93e-10 Hip circumference;Waist circumference; LUSC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC cis rs4561483 0.603 rs11544193 chr16:12009304 C/A cg08843971 chr16:11963173 GSPT1 0.43 6.57 0.34 1.96e-10 Testicular germ cell tumor; LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.85 0.63 1.2e-38 Platelet count; LUSC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg11764359 chr7:65958608 NA 0.78 12.78 0.57 1.04e-30 Aortic root size; LUSC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg14019146 chr3:50243930 SLC38A3 0.37 8.42 0.42 1.12e-15 Body mass index; LUSC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg09359103 chr1:154839909 KCNN3 -0.72 -16.47 -0.67 5.04e-45 Prostate cancer; LUSC cis rs2279817 1.000 rs2354290 chr1:18019861 A/G cg21791023 chr1:18019539 ARHGEF10L 0.51 7.29 0.37 2.2e-12 Neuroticism; LUSC cis rs2050392 0.894 rs2480277 chr10:30703513 G/T cg18806716 chr10:30721971 MAP3K8 0.46 7.48 0.38 6.62e-13 Inflammatory bowel disease; LUSC cis rs2073300 1.000 rs2207989 chr20:23446014 T/G cg09953122 chr20:23471693 CST8 -0.75 -6.87 -0.35 3.15e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2762353 0.935 rs1165152 chr6:25818766 A/G cg03517284 chr6:25882590 NA -0.46 -8.19 -0.41 5.6e-15 Blood metabolite levels; LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg11843238 chr5:131593191 PDLIM4 0.39 7.18 0.37 4.66e-12 Blood metabolite levels; LUSC cis rs9287719 1.000 rs9287719 chr2:10710730 C/T cg00105475 chr2:10696890 NA 0.38 6.24 0.32 1.35e-9 Prostate cancer; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg16606324 chr3:10149918 C3orf24 0.66 9.85 0.47 2.82e-20 Alzheimer's disease; LUSC cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg06784218 chr1:46089804 CCDC17 0.55 11.1 0.52 1.36e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13082711 0.911 rs17019809 chr3:27509080 A/G cg02860705 chr3:27208620 NA 0.47 7.96 0.4 2.67e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6121246 0.529 rs6060144 chr20:30178624 A/G cg13852791 chr20:30311386 BCL2L1 0.7 7.22 0.37 3.49e-12 Mean corpuscular hemoglobin; LUSC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg09165964 chr15:75287851 SCAMP5 0.52 7.59 0.38 3.32e-13 Breast cancer; LUSC cis rs9427116 0.502 rs7531982 chr1:154596122 A/T cg17218026 chr1:154582156 ADAR 0.57 10.15 0.49 2.76e-21 Blood protein levels; LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg14092988 chr3:52407081 DNAH1 0.32 6.31 0.33 8.9e-10 Bipolar disorder; LUSC cis rs1506636 1.000 rs12706545 chr7:123348744 C/T cg03229431 chr7:123269106 ASB15 -0.6 -9.99 -0.48 1.01e-20 Plateletcrit;Platelet count; LUSC cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg05283184 chr6:79620031 NA -0.58 -12.34 -0.56 4.25e-29 Intelligence (multi-trait analysis); LUSC cis rs7851660 0.809 rs10984230 chr9:100660284 C/T cg13688889 chr9:100608707 NA -0.56 -8.66 -0.43 2.08e-16 Strep throat; LUSC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs6840360 0.615 rs7669465 chr4:152609289 C/T cg22705602 chr4:152727874 NA -0.34 -7.41 -0.38 1.01e-12 Intelligence (multi-trait analysis); LUSC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg16928487 chr17:17741425 SREBF1 -0.35 -6.87 -0.35 3.13e-11 Total body bone mineral density; LUSC cis rs11190604 0.767 rs11190533 chr10:102190792 T/C cg07080220 chr10:102295463 HIF1AN 0.61 8.12 0.41 9.34e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg12463550 chr7:65579703 CRCP 0.48 6.79 0.35 5.09e-11 Aortic root size; LUSC trans rs877282 0.891 rs34383514 chr10:800181 T/C cg13042288 chr15:90349979 ANPEP -0.5 -6.94 -0.36 2.01e-11 Uric acid levels; LUSC cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg18240062 chr17:79603768 NPLOC4 0.57 9.82 0.47 3.6e-20 Eye color traits; LUSC cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg26384229 chr12:38710491 ALG10B 0.88 15.08 0.64 1.52e-39 Bladder cancer; LUSC cis rs79387448 0.745 rs6749440 chr2:103101846 C/T cg09003973 chr2:102972529 NA 0.88 8.73 0.43 1.23e-16 Gut microbiota (bacterial taxa); LUSC cis rs7296418 0.699 rs11608297 chr12:123826642 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.53 -0.34 2.44e-10 Platelet count; LUSC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg09359103 chr1:154839909 KCNN3 -0.7 -16.24 -0.66 4.09e-44 Prostate cancer; LUSC cis rs9905704 0.647 rs8077332 chr17:57105223 A/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.42 -0.38 9.62e-13 Testicular germ cell tumor; LUSC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg01448562 chr3:133502909 NA -0.52 -7.75 -0.39 1.12e-13 Iron status biomarkers; LUSC cis rs9311676 0.609 rs62258080 chr3:58367493 G/A cg26110898 chr3:58419937 PDHB 0.44 7.2 0.37 4.01e-12 Systemic lupus erythematosus; LUSC cis rs9297145 1.000 rs9297145 chr7:98759117 A/C cg05967295 chr7:98741636 SMURF1 0.94 15.6 0.65 1.37e-41 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7589342 0.660 rs7571132 chr2:106398913 C/T cg14210321 chr2:106509881 NCK2 -0.42 -6.01 -0.31 4.93e-9 Addiction; LUSC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg27432699 chr2:27873401 GPN1 -0.57 -8.48 -0.42 7.41e-16 Menopause (age at onset); LUSC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg06481639 chr22:41940642 POLR3H -0.53 -6.18 -0.32 1.85e-9 Vitiligo; LUSC cis rs7949030 0.780 rs3017666 chr11:62404417 A/T cg11742103 chr11:62369870 EML3;MTA2 -0.48 -8.21 -0.41 4.75e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12145833 0.538 rs9803701 chr1:243391634 T/C cg02356786 chr1:243265016 LOC731275 -0.63 -5.7 -0.3 2.66e-8 Obesity (early onset extreme); LUSC cis rs11828289 0.607 rs79308902 chr11:23163835 G/A cg20040320 chr11:23191996 NA -0.63 -6.35 -0.33 7e-10 Cancer; LUSC cis rs61931739 0.500 rs7306334 chr12:34482900 A/G cg06521331 chr12:34319734 NA 0.39 6.11 0.32 2.77e-9 Morning vs. evening chronotype; LUSC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.05 -0.36 1.02e-11 Alzheimer's disease (late onset); LUSC cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg12219531 chr12:120966889 COQ5 0.6 8.19 0.41 5.42e-15 High light scatter reticulocyte count; LUSC cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg13770153 chr20:60521292 NA -0.61 -8.39 -0.42 1.43e-15 Body mass index; LUSC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg27432699 chr2:27873401 GPN1 -0.48 -7.09 -0.36 7.82e-12 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg04586622 chr2:25135609 ADCY3 0.4 8.35 0.42 1.81e-15 Body mass index in non-asthmatics; LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.614 rs28687626 chr17:57191904 G/A cg25039879 chr17:56429692 SUPT4H1 0.72 9.24 0.45 2.97e-18 Cognitive test performance; LUSC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.98 0.66 4.41e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs657452 0.722 rs1185222 chr1:49958961 C/T cg20501355 chr17:48785009 ANKRD40 0.39 6.2 0.32 1.68e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg16606324 chr3:10149918 C3orf24 0.59 8.66 0.43 1.98e-16 Alzheimer's disease; LUSC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg15445000 chr17:37608096 MED1 -0.39 -6.71 -0.34 8.49e-11 Glomerular filtration rate (creatinine); LUSC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs7980687 0.657 rs2851447 chr12:123665113 G/C cg05973401 chr12:123451056 ABCB9 0.51 6.97 0.36 1.69e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg13798780 chr7:105162888 PUS7 0.55 5.95 0.31 6.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg06552810 chr11:31128660 NA -0.4 -7.13 -0.36 6.38e-12 Red blood cell count; LUSC cis rs10752881 1.000 rs10797807 chr1:182978873 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs9517313 0.554 rs3809366 chr13:99230266 C/T cg20487152 chr13:99095054 FARP1 -0.42 -7.02 -0.36 1.25e-11 Neuroticism; LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.95 0.44 2.52e-17 Prudent dietary pattern; LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg11645453 chr3:52864694 ITIH4 0.33 7.24 0.37 3.11e-12 Bipolar disorder; LUSC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg20701182 chr2:24300061 SF3B14 0.88 11.35 0.53 1.86e-25 Lymphocyte counts; LUSC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg15352829 chr14:105391018 PLD4 -0.43 -8.98 -0.44 1.99e-17 Rheumatoid arthritis; LUSC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 10.91 0.51 6.39e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs11711311 0.955 rs9860642 chr3:113419211 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.79 0.35 5.08e-11 IgG glycosylation; LUSC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg19622623 chr12:86230825 RASSF9 -0.45 -6.4 -0.33 5.37e-10 Major depressive disorder; LUSC trans rs11992162 0.597 rs6996342 chr8:11784541 C/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.43 -0.33 4.45e-10 Monocyte count; LUSC cis rs965469 1.000 rs2281500 chr20:3262824 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -6.07 -0.32 3.49e-9 IFN-related cytopenia; LUSC cis rs72781680 1.000 rs72796359 chr2:24160545 T/C cg08917208 chr2:24149416 ATAD2B 1.01 10.61 0.5 7.29e-23 Lymphocyte counts; LUSC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg21573476 chr21:45109991 RRP1B -0.4 -6.52 -0.34 2.55e-10 Mean corpuscular volume; LUSC cis rs7106204 0.800 rs6484026 chr11:24214633 G/A ch.11.24196551F chr11:24239977 NA 1.12 13.79 0.6 1.49e-34 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6565180 0.507 rs4471699 chr16:30320307 G/T cg17640201 chr16:30407289 ZNF48 -0.64 -10.71 -0.51 3.22e-23 Tonsillectomy; LUSC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs2439831 0.702 rs3759791 chr15:44090798 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.67 0.43 1.97e-16 Lung cancer in ever smokers; LUSC cis rs877282 0.891 rs12767043 chr10:797943 C/T cg17470449 chr10:769945 NA 0.5 6.9 0.35 2.7e-11 Uric acid levels; LUSC cis rs7296418 0.922 rs12425009 chr12:123502044 C/T cg00376283 chr12:123451042 ABCB9 0.83 13.0 0.58 1.47e-31 Platelet count; LUSC trans rs11098499 0.863 rs6534139 chr4:120449456 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.5 -6.64 -0.34 1.26e-10 Corneal astigmatism; LUSC cis rs10779751 1.000 rs2016559 chr1:11269917 G/T cg08854313 chr1:11322531 MTOR 0.86 14.93 0.63 5.89e-39 Body mass index; LUSC cis rs2692947 0.740 rs4907280 chr2:96402126 A/G cg22654517 chr2:96458247 NA 0.37 6.92 0.35 2.38e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs314370 0.951 rs12705092 chr7:100473550 G/A cg18683606 chr7:100471612 SRRT 0.45 5.96 0.31 6.4e-9 Resting heart rate; LUSC cis rs892961 0.932 rs6501954 chr17:75414398 G/C cg05865280 chr17:75406074 SEPT9 0.46 9.67 0.47 1.13e-19 Airflow obstruction; LUSC cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg04673462 chr1:38461896 NA 0.5 8.34 0.42 1.93e-15 Coronary artery disease; LUSC cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -6.65 -0.34 1.23e-10 Educational attainment; LUSC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg14159672 chr1:205819179 PM20D1 -0.41 -5.89 -0.31 9.53e-9 Parkinson's disease; LUSC cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs7215564 0.730 rs2171023 chr17:78608913 A/T cg23238734 chr17:78661607 RPTOR 0.46 6.11 0.32 2.73e-9 Myopia (pathological); LUSC cis rs1858740 0.509 rs196375 chr3:38422919 C/T cg24069376 chr3:38537580 EXOG 0.39 7.31 0.37 1.96e-12 Schizophrenia; LUSC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg06221963 chr1:154839813 KCNN3 -0.6 -13.15 -0.58 4.23e-32 Prostate cancer; LUSC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.77 0.39 9.52e-14 Major depressive disorder; LUSC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.46 7.08 0.36 8.38e-12 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg04369109 chr6:150039330 LATS1 -0.56 -8.2 -0.41 5.37e-15 Lung cancer; LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs1358748 0.555 rs2815389 chr1:67536583 C/G cg02640540 chr1:67518911 SLC35D1 0.66 6.69 0.34 9.24e-11 Tuberculosis; LUSC trans rs80093141 0.575 rs62001076 chr14:39358792 G/C cg08262584 chr8:54154426 OPRK1 0.43 6.08 0.32 3.32e-9 Common carotid intima-media thickness in HIV infection; LUSC cis rs12422267 0.536 rs12303540 chr12:132609679 A/G cg09764611 chr12:132620959 NA 0.6 8.85 0.44 5.11e-17 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs10751667 0.600 rs10794342 chr11:924904 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.41e-10 Alzheimer's disease (late onset); LUSC cis rs9287719 0.967 rs4669593 chr2:10701908 C/T cg03983476 chr2:10830698 NOL10 -0.37 -5.69 -0.3 2.71e-8 Prostate cancer; LUSC cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.08 0.4 1.22e-14 Height; LUSC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg10755058 chr3:40428713 ENTPD3 -0.33 -5.79 -0.3 1.64e-8 Renal cell carcinoma; LUSC cis rs9356171 0.540 rs2207441 chr6:164325217 G/A cg25752492 chr6:164341247 NA -0.38 -6.53 -0.34 2.52e-10 Diisocyanate-induced asthma; LUSC cis rs965469 0.948 rs2236094 chr20:3260368 C/G cg25506879 chr20:3388711 C20orf194 0.52 5.86 0.31 1.08e-8 IFN-related cytopenia; LUSC cis rs4919694 1.000 rs12242000 chr10:104702413 A/C cg04362960 chr10:104952993 NT5C2 1.15 13.83 0.6 1.01e-34 Arsenic metabolism; LUSC cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg08085267 chr17:45401833 C17orf57 -0.54 -8.54 -0.42 4.71e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs12310956 0.532 rs1906134 chr12:33957135 A/C cg13010199 chr12:38710504 ALG10B 0.56 8.42 0.42 1.11e-15 Morning vs. evening chronotype; LUSC cis rs1577917 0.740 rs2758842 chr6:86308731 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -9.52 -0.46 3.74e-19 Response to antipsychotic treatment; LUSC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg07395648 chr5:131743802 NA -0.45 -7.16 -0.36 5.21e-12 Breast cancer;Mosquito bite size; LUSC cis rs4597304 1 rs4597304 chr16:85055741 G/C cg01715842 chr16:85045600 ZDHHC7 -0.5 -7.09 -0.36 8.01e-12 Dysphagia; LUSC cis rs738321 0.794 rs6001026 chr22:38545363 C/T cg25457927 chr22:38595422 NA -0.42 -8.15 -0.41 7.45e-15 Breast cancer; LUSC cis rs929354 0.739 rs1182439 chr7:157027367 G/A cg05182265 chr7:156933206 UBE3C 0.59 9.67 0.47 1.17e-19 Body mass index; LUSC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg13114125 chr14:105738426 BRF1 -0.9 -15.57 -0.65 1.73e-41 Mean platelet volume;Platelet distribution width; LUSC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.7 11.96 0.55 1.13e-27 Intelligence (multi-trait analysis); LUSC trans rs9630182 0.520 rs2290035 chr11:13407771 T/A cg00234616 chr2:74740572 TLX2 0.3 6.09 0.32 3.03e-9 Bone mineral density; LUSC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg15335139 chr3:50242325 SLC38A3 -0.26 -5.71 -0.3 2.5e-8 Body mass index; LUSC cis rs9807989 0.507 rs6743516 chr2:103036335 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.35e-12 Asthma; LUSC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg03909863 chr11:638404 DRD4 -0.42 -6.02 -0.31 4.59e-9 Systemic lupus erythematosus; LUSC cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg06454157 chr6:167490870 NA -0.28 -6.75 -0.35 6.53e-11 Primary biliary cholangitis; LUSC cis rs950169 0.840 rs12905223 chr15:85114268 T/C cg12863693 chr15:85201151 NMB 0.34 7.01 0.36 1.34e-11 Schizophrenia; LUSC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg13319975 chr6:146136371 FBXO30 0.51 7.65 0.39 2.16e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs5770917 1.000 rs17848459 chr22:51012311 G/T cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.59 -5.69 -0.3 2.84e-8 Narcolepsy; LUSC cis rs11229555 0.645 rs11530830 chr11:58252992 C/G cg15696309 chr11:58395628 NA 0.66 8.01 0.4 1.99e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7586879 0.828 rs1865688 chr2:25108245 C/G cg01884057 chr2:25150051 NA 0.41 8.61 0.43 3.02e-16 Body mass index; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1348850 0.539 rs1453371 chr2:178227862 T/G cg22681709 chr2:178499509 PDE11A -0.34 -6.21 -0.32 1.57e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg19717773 chr7:2847554 GNA12 -0.35 -5.87 -0.31 1.08e-8 Height; LUSC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg03806693 chr22:41940476 POLR3H -0.99 -13.97 -0.61 2.95e-35 Vitiligo; LUSC cis rs4595586 0.545 rs2218762 chr12:39397762 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC trans rs7819412 0.539 rs11250131 chr8:11251175 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.59 -0.34 1.71e-10 Triglycerides; LUSC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.52 -7.12 -0.36 6.86e-12 Mean platelet volume; LUSC cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg03146154 chr1:46216737 IPP 0.53 7.86 0.4 5.39e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1775715 0.870 rs7095322 chr10:32248491 C/T cg18675610 chr10:32216311 ARHGAP12 -0.28 -5.89 -0.31 9.32e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10779751 0.734 rs2261317 chr1:11124979 A/G cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg15790184 chr11:494944 RNH1 0.42 6.21 0.32 1.61e-9 Systemic lupus erythematosus; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg19318889 chr4:1322082 MAEA 0.77 14.56 0.62 1.51e-37 Longevity; LUSC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg06022373 chr22:39101656 GTPBP1 0.84 14.01 0.61 2.07e-35 Menopause (age at onset); LUSC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.72 -0.3 2.43e-8 Tonsillectomy; LUSC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg11764359 chr7:65958608 NA 0.7 10.58 0.5 9.36e-23 Aortic root size; LUSC cis rs992157 0.735 rs10932765 chr2:219099484 T/C cg00012203 chr2:219082015 ARPC2 0.89 17.23 0.69 4.76e-48 Colorectal cancer; LUSC cis rs1577917 1.000 rs7771342 chr6:86631936 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC trans rs8072100 0.875 rs7208530 chr17:45544107 C/T cg03886242 chr7:26192032 NFE2L3 -0.42 -6.66 -0.34 1.11e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg13620615 chr21:40555724 PSMG1 0.52 6.19 0.32 1.81e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg14552801 chr7:65878734 NA 0.45 6.34 0.33 7.34e-10 Aortic root size; LUSC cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg16230307 chr14:35515116 FAM177A1 0.74 8.78 0.43 8.84e-17 Psoriasis; LUSC cis rs8060686 0.641 rs55790290 chr16:68180242 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7212590 0.618 rs7219051 chr17:58032710 G/A cg10252138 chr17:58120427 NA -0.8 -7.53 -0.38 4.68e-13 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg11244672 chr19:19639970 YJEFN3 -0.58 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg10150615 chr22:24372951 LOC391322 -0.41 -6.54 -0.34 2.31e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg17143192 chr8:8559678 CLDN23 0.62 9.06 0.44 1.12e-17 Obesity-related traits; LUSC cis rs10979 0.964 rs9321922 chr6:143895231 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg21724239 chr8:58056113 NA -0.81 -8.97 -0.44 2.13e-17 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC cis rs714027 0.585 rs41156 chr22:30404653 T/C cg11564601 chr22:30592435 NA -0.34 -5.9 -0.31 9.1e-9 Lymphocyte counts; LUSC cis rs8064299 0.597 rs6501736 chr17:72775358 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.92 18.2 0.71 6.83e-52 Monocyte count; LUSC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg23093090 chr10:104574429 C10orf26 -0.37 -7.1 -0.36 7.73e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs3540 0.553 rs12592611 chr15:91004093 C/T cg22089800 chr15:90895588 ZNF774 0.64 9.68 0.47 1.05e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs61931739 0.534 rs11052984 chr12:34045904 T/C cg13010199 chr12:38710504 ALG10B 0.53 7.97 0.4 2.47e-14 Morning vs. evening chronotype; LUSC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg12432903 chr7:1882776 MAD1L1 0.53 6.7 0.34 9.1e-11 Bipolar disorder; LUSC cis rs13242816 1.000 rs55803834 chr7:116103141 C/T cg16553024 chr7:116138462 CAV2 -0.53 -5.81 -0.3 1.46e-8 P wave duration; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg21444639 chr1:171711847 VAMP4 0.43 6.38 0.33 5.9e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg01579765 chr21:45077557 HSF2BP -0.57 -12.24 -0.56 1.06e-28 Mean corpuscular volume; LUSC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg08355456 chr11:67383691 NA 0.36 6.68 0.34 1.03e-10 Mean corpuscular volume; LUSC cis rs10789491 1.000 rs4660956 chr1:47158486 A/G cg15501359 chr1:47185051 KIAA0494 0.77 10.97 0.51 4.21e-24 Response to hepatitis C treatment; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14433247 chr12:14923044 NA -0.42 -6.24 -0.32 1.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.99 -0.4 2.18e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs983392 0.709 rs1426250 chr11:60001325 A/G cg02771260 chr11:59836817 MS4A3 -0.37 -5.96 -0.31 6.5e-9 Alzheimer's disease (late onset); LUSC cis rs2898290 0.540 rs12677146 chr8:11450737 C/G cg21175976 chr8:11421337 BLK -0.38 -6.55 -0.34 2.24e-10 Systolic blood pressure; LUSC cis rs9677476 0.909 rs7562116 chr2:232108246 A/G cg07929768 chr2:232055508 NA 0.35 6.44 0.33 4.21e-10 Food antigen IgG levels; LUSC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg09491104 chr22:46646882 C22orf40 -0.67 -7.0 -0.36 1.42e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs2439831 0.850 rs28413881 chr15:44174099 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.47 0.33 3.46e-10 Lung cancer in ever smokers; LUSC cis rs4919694 0.908 rs11191523 chr10:104792400 A/G cg23093090 chr10:104574429 C10orf26 -0.47 -5.76 -0.3 1.94e-8 Arsenic metabolism; LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg02018176 chr4:1364513 KIAA1530 -0.58 -9.97 -0.48 1.13e-20 Obesity-related traits; LUSC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg24250549 chr1:154909240 PMVK 0.55 8.72 0.43 1.38e-16 Prostate cancer; LUSC trans rs7824557 0.583 rs2263512 chr8:11233419 T/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.14 -0.41 7.68e-15 Retinal vascular caliber; LUSC cis rs6429082 0.715 rs2131923 chr1:235580821 A/G cg26050004 chr1:235667680 B3GALNT2 -0.55 -7.83 -0.39 6.38e-14 Adiposity; LUSC cis rs12682352 0.602 rs28399241 chr8:8663215 C/T cg08975724 chr8:8085496 FLJ10661 0.44 6.05 0.31 3.78e-9 Neuroticism; LUSC cis rs1595825 0.891 rs73054808 chr2:198602283 C/T cg00982548 chr2:198649783 BOLL -0.54 -6.63 -0.34 1.33e-10 Ulcerative colitis; LUSC cis rs240764 0.621 rs11155623 chr6:101184373 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.4 -0.33 5.21e-10 Neuroticism; LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.11 0.64 1.18e-39 Platelet count; LUSC cis rs394563 1.000 rs394563 chr6:149797014 T/G cg03678062 chr6:149772716 ZC3H12D -0.31 -6.44 -0.33 4.21e-10 Dupuytren's disease; LUSC cis rs4363385 0.747 rs4845330 chr1:152981505 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.33e-13 Inflammatory skin disease; LUSC cis rs7927771 0.524 rs7943464 chr11:47886639 T/A cg20307385 chr11:47447363 PSMC3 0.47 6.86 0.35 3.42e-11 Subjective well-being; LUSC cis rs68170813 0.559 rs1002935 chr7:106832361 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.75 -0.47 6.45e-20 Coronary artery disease; LUSC cis rs34375054 0.624 rs7295689 chr12:125680922 T/G cg06287003 chr12:125626642 AACS -0.36 -5.66 -0.3 3.24e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg09034736 chr1:150693464 HORMAD1 -0.4 -5.75 -0.3 2.05e-8 Tonsillectomy; LUSC cis rs1559088 0.948 rs12608825 chr19:33581219 C/T cg17764715 chr19:33622953 WDR88 -0.59 -8.12 -0.41 9.04e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 5.92 0.31 7.92e-9 Personality dimensions; LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.51 -7.02 -0.36 1.21e-11 Renal function-related traits (BUN); LUSC trans rs7613875 0.580 rs11709503 chr3:49991167 G/T cg21659725 chr3:3221576 CRBN 0.54 8.74 0.43 1.17e-16 Body mass index; LUSC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg12560992 chr17:57184187 TRIM37 0.82 14.77 0.63 2.39e-38 Intelligence (multi-trait analysis); LUSC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg04013166 chr16:89971882 TCF25 -0.63 -7.28 -0.37 2.35e-12 Skin colour saturation; LUSC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg09417038 chr21:47716443 C21orf57 -0.41 -6.54 -0.34 2.27e-10 Testicular germ cell tumor; LUSC cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.64 8.51 0.42 6.03e-16 Response to bleomycin (chromatid breaks); LUSC cis rs7216064 0.953 rs58141639 chr17:65864902 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs12210905 0.688 rs78285097 chr6:27374644 G/C cg08851530 chr6:28072375 NA 0.97 6.41 0.33 4.91e-10 Hip circumference adjusted for BMI; LUSC cis rs950169 0.610 rs34529571 chr15:84691807 A/G cg17507749 chr15:85114479 UBE2QP1 0.56 6.39 0.33 5.58e-10 Schizophrenia; LUSC cis rs12122100 0.526 rs12122534 chr1:146504399 A/G cg03526459 chr1:146549940 NA 0.41 7.27 0.37 2.53e-12 HIV-1 control; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24542492 chr17:61818870 STRADA -0.51 -6.72 -0.35 7.68e-11 Bipolar disorder and schizophrenia; LUSC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11890956 chr21:40555474 PSMG1 0.74 12.0 0.55 8.09e-28 Cognitive function; LUSC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg03806693 chr22:41940476 POLR3H -1.05 -15.3 -0.64 1.96e-40 Vitiligo; LUSC cis rs10207060 0.500 rs10181238 chr2:240709496 G/A cg07506560 chr2:240697449 NA 0.48 7.35 0.37 1.56e-12 Obesity-related traits; LUSC cis rs7582180 0.652 rs11675901 chr2:100951189 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.45e-8 Intelligence (multi-trait analysis); LUSC cis rs8014204 0.869 rs2070599 chr14:75361177 C/G cg08847533 chr14:75593920 NEK9 -0.39 -5.71 -0.3 2.47e-8 Caffeine consumption; LUSC cis rs2346177 0.846 rs6714738 chr2:46646164 G/A cg02822958 chr2:46747628 ATP6V1E2 0.35 5.95 0.31 6.66e-9 HDL cholesterol; LUSC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.08e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs10089 0.953 rs6879970 chr5:127387178 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 12.09 0.55 3.72e-28 Ileal carcinoids; LUSC cis rs9393777 0.720 rs36022097 chr6:26995168 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.54 -6.36 -0.33 6.81e-10 Intelligence (multi-trait analysis); LUSC cis rs8048589 0.526 rs71388721 chr16:12212164 G/A cg02910054 chr16:12241554 SNX29 0.5 7.02 0.36 1.26e-11 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs12922317 0.927 rs12923439 chr16:12073958 C/T cg08843971 chr16:11963173 GSPT1 -0.39 -5.69 -0.3 2.84e-8 Schizophrenia; LUSC cis rs2130392 1.000 rs4862406 chr4:185629339 G/A cg21366198 chr4:185655624 MLF1IP 0.42 5.91 0.31 8.36e-9 Kawasaki disease; LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 5.01e-10 Systemic lupus erythematosus; LUSC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg01448562 chr3:133502909 NA -0.67 -10.98 -0.51 3.83e-24 Iron status biomarkers; LUSC trans rs61931739 0.612 rs1906136 chr12:33905293 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.66 0.39 2.1e-13 Morning vs. evening chronotype; LUSC cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg00152838 chr16:24741724 TNRC6A -0.46 -5.71 -0.3 2.55e-8 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg06481639 chr22:41940642 POLR3H -0.51 -6.14 -0.32 2.41e-9 Vitiligo; LUSC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.36 0.42 1.71e-15 Arsenic metabolism; LUSC cis rs2688608 0.904 rs2675669 chr10:75653872 C/T cg17411546 chr10:75410026 SYNPO2L -0.43 -6.42 -0.33 4.66e-10 Inflammatory bowel disease; LUSC cis rs7107174 1.000 rs10899460 chr11:78010080 A/G cg02023728 chr11:77925099 USP35 0.49 6.88 0.35 3.02e-11 Testicular germ cell tumor; LUSC cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg21535247 chr6:8435926 SLC35B3 -0.64 -8.75 -0.43 1.1e-16 Motion sickness; LUSC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg27427491 chr17:78079615 GAA -0.36 -6.94 -0.35 2.09e-11 Yeast infection; LUSC cis rs7582720 1.000 rs72934707 chr2:203707878 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.75 8.16 0.41 7.08e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2439831 0.867 rs935901 chr15:43651256 G/C cg02155558 chr15:43621948 ADAL;LCMT2 1.14 12.3 0.56 6.26e-29 Lung cancer in ever smokers; LUSC cis rs11098499 0.604 rs2389882 chr4:120566733 A/C cg09307838 chr4:120376055 NA 0.67 9.49 0.46 4.49e-19 Corneal astigmatism; LUSC cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg13770153 chr20:60521292 NA -0.61 -8.39 -0.42 1.43e-15 Body mass index; LUSC cis rs2386661 0.591 rs11255051 chr10:5653450 A/G cg17085576 chr10:5658249 NA -0.46 -6.79 -0.35 5.06e-11 Breast cancer; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg22166914 chr1:53195759 ZYG11B 0.56 9.12 0.45 6.96e-18 Monocyte count; LUSC cis rs7818345 0.967 rs7006702 chr8:19272533 G/C cg11303988 chr8:19266685 CSGALNACT1 0.38 7.28 0.37 2.35e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg27588902 chr6:42928151 GNMT -0.29 -6.49 -0.33 3.11e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg24642439 chr20:33292090 TP53INP2 0.55 8.19 0.41 5.74e-15 Height; LUSC cis rs3087591 1.000 rs7226006 chr17:29650656 A/G cg24425628 chr17:29625626 OMG;NF1 -0.59 -8.36 -0.42 1.71e-15 Hip circumference; LUSC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg11941060 chr3:133502564 NA -0.46 -6.63 -0.34 1.32e-10 Iron status biomarkers; LUSC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11890956 chr21:40555474 PSMG1 0.91 16.53 0.67 2.89e-45 Cognitive function; LUSC cis rs1953600 0.870 rs1049550 chr10:81926702 G/A cg04850286 chr10:81895943 PLAC9 -0.35 -6.01 -0.31 4.91e-9 Sarcoidosis; LUSC cis rs12594515 1.000 rs6493175 chr15:45989898 T/C cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.45e-8 Aortic root size; LUSC cis rs2404618 0.506 rs12156177 chr8:1493684 C/T cg02903104 chr8:1507517 DLGAP2 0.33 6.52 0.34 2.65e-10 Lung cancer; LUSC cis rs12210905 0.565 rs9689239 chr6:26881879 C/G cg23155468 chr6:27110703 HIST1H2BK -0.64 -5.66 -0.3 3.25e-8 Hip circumference adjusted for BMI; LUSC cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg23788917 chr6:8435910 SLC35B3 0.48 7.02 0.36 1.23e-11 Motion sickness; LUSC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg08439880 chr3:133502540 NA -0.33 -6.01 -0.31 4.89e-9 Iron status biomarkers; LUSC cis rs7615952 0.800 rs11915699 chr3:125632684 A/G cg05084668 chr3:125655381 ALG1L -0.75 -11.12 -0.52 1.15e-24 Blood pressure (smoking interaction); LUSC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg15704280 chr7:45808275 SEPT13 -1.1 -22.36 -0.77 2.43e-68 Coronary artery disease; LUSC cis rs6733011 0.508 rs13004700 chr2:99527568 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.99 -0.36 1.55e-11 Bipolar disorder; LUSC cis rs7937682 0.889 rs1789355 chr11:111499718 T/C cg09085632 chr11:111637200 PPP2R1B -1.12 -18.16 -0.7 9.73e-52 Primary sclerosing cholangitis; LUSC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.43 -7.08 -0.36 8.79e-12 Platelet count; LUSC trans rs9929218 0.954 rs9929239 chr16:68821126 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.42 -0.53 9.9e-26 Colorectal cancer; LUSC cis rs12200560 0.505 rs211173 chr6:97070804 C/T cg06623918 chr6:96969491 KIAA0776 0.49 7.07 0.36 8.98e-12 Coronary heart disease; LUSC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08704250 chr15:31115839 NA -0.6 -9.34 -0.46 1.41e-18 Huntington's disease progression; LUSC cis rs7178572 0.524 rs12914128 chr15:77493875 T/C cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs7577851 0.716 rs67481136 chr2:69668004 C/A cg10773587 chr2:69614142 GFPT1 0.57 6.23 0.32 1.38e-9 Parkinson's disease (age of onset); LUSC cis rs6542838 0.641 rs12712042 chr2:99534401 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.62 -0.34 1.44e-10 Fear of minor pain; LUSC cis rs2204008 0.805 rs4882575 chr12:37940573 G/A cg26384229 chr12:38710491 ALG10B -0.83 -13.9 -0.61 5.41e-35 Bladder cancer; LUSC cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg08645402 chr16:4508243 NA 0.45 6.77 0.35 5.89e-11 Schizophrenia; LUSC cis rs2548003 0.518 rs2554901 chr5:28733310 T/C cg22863700 chr5:28928346 NA 0.45 6.22 0.32 1.45e-9 Hip geometry; LUSC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.59 0.34 1.73e-10 Renal cell carcinoma; LUSC trans rs7937682 0.824 rs11213962 chr11:111506027 G/A cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs10193935 0.901 rs92303 chr2:42656337 A/G cg27598129 chr2:42591480 NA 0.57 7.94 0.4 3.01e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs7647973 0.626 rs9870858 chr3:49769071 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -7.01 -0.36 1.29e-11 Menarche (age at onset); LUSC trans rs11098499 0.530 rs114866537 chr4:120258608 A/T cg25214090 chr10:38739885 LOC399744 0.41 6.35 0.33 6.98e-10 Corneal astigmatism; LUSC cis rs9921338 0.961 rs7187870 chr16:11431919 T/C cg00044050 chr16:11439710 C16orf75 -0.5 -6.69 -0.34 9.4e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs9788682 1.000 rs35212593 chr15:78831826 G/A cg18825076 chr15:78729989 IREB2 0.48 6.31 0.33 8.8e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11792861 0.926 rs12686736 chr9:111888739 A/G cg05043794 chr9:111880884 C9orf5 -0.35 -7.55 -0.38 4.16e-13 Menarche (age at onset); LUSC cis rs4776059 0.798 rs2414167 chr15:52907428 A/G cg24008177 chr15:52972085 KIAA1370 -0.33 -5.92 -0.31 7.93e-9 Schizophrenia; LUSC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.68 -0.3 2.94e-8 Life satisfaction; LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.39 0.67 1.04e-44 Platelet count; LUSC trans rs6496932 0.774 rs12901648 chr15:85951718 G/T cg02291556 chr1:47656140 PDZK1IP1 0.43 6.2 0.32 1.67e-9 Central corneal thickness;Corneal structure; LUSC cis rs3806843 0.933 rs2879087 chr5:140188575 G/C cg26395211 chr5:140044315 WDR55 -0.37 -5.65 -0.3 3.4e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs17750015 0.733 rs7506986 chr18:54404558 C/T cg18434998 chr18:54306185 TXNL1 -0.47 -7.5 -0.38 5.69e-13 Depression and alcohol dependence; LUSC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg13319975 chr6:146136371 FBXO30 0.47 7.25 0.37 2.91e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs73195822 0.614 rs11834902 chr12:111219809 C/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.61 0.34 1.5e-10 Itch intensity from mosquito bite; LUSC cis rs2692947 0.683 rs2315416 chr2:96558477 C/T cg22654517 chr2:96458247 NA 0.38 7.58 0.38 3.45e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6714710 0.603 rs11681535 chr2:98488949 G/C cg26665480 chr2:98280029 ACTR1B 0.59 8.68 0.43 1.73e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1371867 0.846 rs1788204 chr8:101303936 C/T cg00191853 chr8:101177733 SPAG1 -0.41 -6.56 -0.34 2.08e-10 Atrioventricular conduction; LUSC cis rs2067615 0.524 rs10778503 chr12:107090616 C/T cg15890332 chr12:107067104 RFX4 0.35 6.15 0.32 2.24e-9 Heart rate; LUSC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg04518342 chr5:131593106 PDLIM4 0.32 5.66 0.3 3.28e-8 Breast cancer;Mosquito bite size; LUSC cis rs951366 0.576 rs1832775 chr1:205734032 C/T cg07167872 chr1:205819463 PM20D1 -0.43 -5.84 -0.3 1.21e-8 Menarche (age at onset); LUSC cis rs11190604 1.000 rs7070776 chr10:102264672 A/G cg07080220 chr10:102295463 HIF1AN 0.67 9.17 0.45 4.96e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs870825 0.655 rs28661636 chr4:185634218 A/C cg04058563 chr4:185651563 MLF1IP 0.88 13.19 0.59 2.82e-32 Blood protein levels; LUSC cis rs2625529 0.652 rs2278987 chr15:72409769 T/C cg16672083 chr15:72433130 SENP8 0.49 8.14 0.41 7.93e-15 Red blood cell count; LUSC cis rs9811920 0.965 rs9289981 chr3:99868104 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.38 5.65 0.3 3.41e-8 Axial length; LUSC cis rs1577917 0.771 rs4145082 chr6:86352016 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.0 -0.52 3.09e-24 Response to antipsychotic treatment; LUSC cis rs2070488 0.775 rs4407366 chr3:38521425 C/T cg24069376 chr3:38537580 EXOG 0.42 8.21 0.41 4.88e-15 Electrocardiographic conduction measures; LUSC cis rs881375 0.678 rs1930782 chr9:123687905 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 5.98 0.31 5.86e-9 Rheumatoid arthritis; LUSC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg22920501 chr2:26401640 FAM59B -0.72 -10.23 -0.49 1.52e-21 Gut microbiome composition (summer); LUSC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg11062466 chr8:58055876 NA 0.61 7.5 0.38 5.71e-13 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg04455712 chr21:45112962 RRP1B 0.45 8.53 0.42 5.06e-16 Mean corpuscular volume; LUSC cis rs2219968 0.798 rs9657126 chr8:78942271 T/C cg00738934 chr8:78996279 NA -0.4 -7.22 -0.37 3.56e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs644799 0.648 rs1255181 chr11:95472148 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.58 8.86 0.44 4.85e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12545109 0.879 rs1581129 chr8:57377476 T/C cg09654669 chr8:57350985 NA -0.57 -7.46 -0.38 7.7e-13 Obesity-related traits; LUSC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg16680214 chr1:154839983 KCNN3 -0.58 -11.29 -0.53 3.05e-25 Prostate cancer; LUSC cis rs4843185 0.667 rs4143865 chr16:85716612 T/A cg05245094 chr16:85669572 KIAA0182 0.43 6.13 0.32 2.53e-9 Platelet distribution width; LUSC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.15 0.49 2.87e-21 Electroencephalogram traits; LUSC cis rs11148252 0.553 rs2147692 chr13:53287023 C/G cg00495681 chr13:53174319 NA 0.79 15.57 0.65 1.72e-41 Lewy body disease; LUSC cis rs5771069 0.896 rs137862 chr22:50446550 C/A cg03721641 chr22:50451245 IL17REL 0.29 5.9 0.31 9.02e-9 Ulcerative colitis; LUSC cis rs2251381 0.523 rs2832306 chr21:30754468 C/T cg24692254 chr21:30365293 RNF160 -0.53 -8.06 -0.4 1.33e-14 Selective IgA deficiency; LUSC cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.84 -13.7 -0.6 3.17e-34 Chronic sinus infection; LUSC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg20398880 chr6:41068722 NFYA;LOC221442 0.39 6.05 0.31 3.96e-9 Alzheimer's disease (late onset); LUSC cis rs7805747 0.961 rs10224002 chr7:151415041 C/T cg17611936 chr7:151411526 PRKAG2 -0.49 -6.97 -0.36 1.67e-11 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); LUSC trans rs7395662 0.517 rs10838960 chr11:48584741 A/G cg21153622 chr11:89784906 NA -0.4 -6.19 -0.32 1.75e-9 HDL cholesterol; LUSC trans rs724744 0.660 rs1737234 chr6:22351804 T/C cg13807341 chr11:118445984 ARCN1 -0.36 -6.15 -0.32 2.18e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs10782582 0.564 rs17647711 chr1:76241710 C/G cg03433033 chr1:76189801 ACADM -0.39 -5.66 -0.3 3.35e-8 Daytime sleep phenotypes; LUSC cis rs611744 0.647 rs1379336 chr8:109276606 G/T cg21045802 chr8:109455806 TTC35 0.43 6.62 0.34 1.45e-10 Dupuytren's disease; LUSC cis rs6120849 0.754 rs6120793 chr20:33604407 T/C cg24642439 chr20:33292090 TP53INP2 0.62 6.82 0.35 4.29e-11 Protein C levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13862631 chr4:78979894 FRAS1 0.43 6.08 0.32 3.25e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs546131 0.890 rs496558 chr11:34826425 C/T cg11058730 chr11:34937778 PDHX;APIP 0.44 5.91 0.31 8.32e-9 Lung disease severity in cystic fibrosis; LUSC cis rs6546537 0.550 rs12617329 chr2:69781530 C/A cg10773587 chr2:69614142 GFPT1 -0.42 -6.66 -0.34 1.14e-10 Serum thyroid-stimulating hormone levels; LUSC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg24562669 chr7:97807699 LMTK2 0.34 5.95 0.31 6.83e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs853679 0.546 rs493161 chr6:27850714 A/T cg06606381 chr12:133084897 FBRSL1 -0.8 -7.48 -0.38 6.73e-13 Depression; LUSC cis rs7771547 0.607 rs6923993 chr6:36427276 A/G cg07856975 chr6:36356162 ETV7 0.34 5.98 0.31 5.9e-9 Platelet distribution width; LUSC cis rs7804356 1.000 rs12540045 chr7:26863174 C/G cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg00033643 chr7:134001901 SLC35B4 0.45 7.02 0.36 1.22e-11 Mean platelet volume; LUSC cis rs3806843 1.000 rs2337985 chr5:140157861 T/C cg19875535 chr5:140030758 IK 0.49 8.11 0.41 9.5e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2070488 0.560 rs1381798 chr3:38437471 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.66 -9.88 -0.48 2.29e-20 Electrocardiographic conduction measures; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg06873352 chr17:61820015 STRADA 0.72 12.97 0.58 1.89e-31 Prudent dietary pattern; LUSC cis rs2180341 0.538 rs4577822 chr6:127712911 T/G cg24812749 chr6:127587940 RNF146 0.49 7.16 0.36 5.1e-12 Breast cancer; LUSC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg06671706 chr8:8559999 CLDN23 0.51 6.96 0.36 1.8e-11 Obesity-related traits; LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.2 -0.32 1.7e-9 Bipolar disorder and schizophrenia; LUSC trans rs9929218 0.551 rs3785134 chr16:68728938 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.06 23.48 0.79 1.08e-72 Colorectal cancer; LUSC cis rs73206853 0.841 rs73191815 chr12:110914698 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1395 0.710 rs1992291 chr2:27504312 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 6.31 0.33 8.76e-10 Blood metabolite levels; LUSC cis rs11098499 0.564 rs11098507 chr4:120288286 G/A cg24375607 chr4:120327624 NA 0.69 10.58 0.5 9.66e-23 Corneal astigmatism; LUSC cis rs56283067 0.887 rs12198016 chr6:44771708 C/T cg18551225 chr6:44695536 NA -0.45 -6.99 -0.36 1.47e-11 Total body bone mineral density; LUSC cis rs4499344 0.531 rs863905 chr19:33146403 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.7 10.44 0.5 2.84e-22 Mean platelet volume; LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg08200582 chr11:442649 ANO9 -0.57 -6.04 -0.31 4.22e-9 Body mass index; LUSC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.27 0.37 2.51e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.73 -0.35 7.19e-11 Alzheimer's disease (late onset); LUSC trans rs7615952 0.599 rs2279821 chr3:125734308 G/A cg07211511 chr3:129823064 LOC729375 -0.78 -10.17 -0.49 2.36e-21 Blood pressure (smoking interaction); LUSC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg11941060 chr3:133502564 NA -0.52 -8.07 -0.4 1.25e-14 Iron status biomarkers; LUSC cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg00631329 chr6:26305371 NA -0.46 -9.23 -0.45 3.18e-18 Educational attainment; LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.32 0.33 8.38e-10 Menopause (age at onset); LUSC cis rs4065321 0.522 rs3744245 chr17:38146542 C/G cg17467752 chr17:38218738 THRA -0.5 -7.05 -0.36 1.05e-11 White blood cell count (basophil);White blood cell count; LUSC cis rs6893807 0.778 rs7721099 chr5:87936379 A/G cg02225085 chr5:87975992 LOC645323 -0.46 -5.67 -0.3 3.11e-8 Body mass index; LUSC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg18230493 chr5:56204884 C5orf35 -0.91 -13.32 -0.59 9.56e-33 Initial pursuit acceleration; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg06441968 chr1:40627537 RLF 0.52 6.43 0.33 4.43e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs3942852 0.568 rs1039484 chr11:48097948 A/G cg15704280 chr7:45808275 SEPT13 -0.62 -8.13 -0.41 8.56e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs834811 0.865 rs844327 chr7:135898043 G/T cg01726295 chr7:135938950 NA 0.34 6.07 0.32 3.47e-9 Post-traumatic stress disorder; LUSC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs10927875 0.619 rs2013019 chr1:16129320 T/C cg22431228 chr1:16359049 CLCNKA 0.31 6.34 0.33 7.39e-10 Dilated cardiomyopathy; LUSC trans rs6982636 1.000 rs6982636 chr8:126479315 G/A cg13325919 chr3:181432053 SOX2;SOX2OT -0.34 -6.43 -0.33 4.46e-10 Lipid metabolism phenotypes; LUSC cis rs7605827 0.866 rs2160696 chr2:15518983 A/T cg19274914 chr2:15703543 NA 0.45 8.73 0.43 1.27e-16 Educational attainment (years of education); LUSC cis rs9341808 0.718 rs3805922 chr6:80891989 A/G cg08355045 chr6:80787529 NA 0.58 10.07 0.48 5.31e-21 Sitting height ratio; LUSC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg09021430 chr5:549028 NA -0.57 -7.67 -0.39 1.92e-13 Obesity-related traits; LUSC cis rs12478296 1.000 rs7420157 chr2:243005204 G/A cg06360820 chr2:242988706 NA -0.83 -9.58 -0.46 2.22e-19 Obesity-related traits; LUSC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg10523679 chr1:76189770 ACADM 0.82 10.74 0.51 2.54e-23 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg07424592 chr7:64974309 NA 0.7 6.05 0.31 3.99e-9 Diabetic kidney disease; LUSC cis rs11676348 0.755 rs62183956 chr2:219046122 C/T cg06547715 chr2:218990976 CXCR2 -0.31 -6.24 -0.32 1.31e-9 Ulcerative colitis; LUSC cis rs6570726 0.526 rs9376928 chr6:145724403 T/G cg23711669 chr6:146136114 FBXO30 -0.49 -7.37 -0.37 1.38e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 1.000 rs72781658 chr2:24220141 A/G cg20701182 chr2:24300061 SF3B14 0.76 7.72 0.39 1.39e-13 Lymphocyte counts; LUSC cis rs2204008 0.694 rs1672436 chr12:38132547 G/T cg26384229 chr12:38710491 ALG10B -0.67 -10.25 -0.49 1.32e-21 Bladder cancer; LUSC trans rs6502050 0.830 rs8074436 chr17:80158422 A/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.81e-10 Life satisfaction; LUSC cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg16386425 chr10:429943 DIP2C 0.41 6.0 0.31 5.08e-9 Psychosis in Alzheimer's disease; LUSC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg22875332 chr1:76189707 ACADM -0.79 -10.76 -0.51 2.31e-23 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg03676636 chr4:99064102 C4orf37 0.33 7.19 0.37 4.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg15664640 chr17:80829946 TBCD -0.74 -13.43 -0.59 3.66e-33 Breast cancer; LUSC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg21951975 chr1:209979733 IRF6 0.61 7.89 0.4 4.43e-14 Cleft lip with or without cleft palate; LUSC cis rs9522267 0.535 rs2039915 chr13:112238794 C/T cg10483660 chr13:112241077 NA -0.31 -5.77 -0.3 1.81e-8 Hepatitis; LUSC cis rs950027 0.549 rs2899375 chr15:45598335 G/A cg26924012 chr15:45694286 SPATA5L1 -0.76 -11.29 -0.53 3.04e-25 Response to fenofibrate (adiponectin levels); LUSC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg05738196 chr6:26577821 NA -0.6 -7.03 -0.36 1.15e-11 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg25039879 chr17:56429692 SUPT4H1 0.66 8.81 0.43 6.99e-17 Cognitive test performance; LUSC cis rs7937682 0.921 rs10891280 chr11:111433609 A/T cg11344533 chr11:111475393 SIK2 0.44 5.76 0.3 1.93e-8 Primary sclerosing cholangitis; LUSC cis rs9648716 0.515 rs62485390 chr7:140662686 T/G cg23214464 chr7:140373596 ADCK2 0.67 5.86 0.31 1.12e-8 Type 2 diabetes; LUSC cis rs782590 0.557 rs7592219 chr2:55887176 T/C cg03859395 chr2:55845619 SMEK2 -0.64 -9.07 -0.44 1e-17 Metabolic syndrome; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T ch.6.143706070F chr6:143664377 NA 0.38 6.24 0.32 1.34e-9 Triglycerides; LUSC trans rs1448094 0.817 rs7972773 chr12:86340774 A/C cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.1 0.32 2.85e-9 Schizophrenia; LUSC cis rs3931020 0.688 rs405445 chr1:75221150 C/T cg21535942 chr1:75199100 CRYZ;TYW3 -0.45 -5.78 -0.3 1.68e-8 Resistin levels; LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg09877947 chr5:131593287 PDLIM4 0.5 7.85 0.39 5.84e-14 Acylcarnitine levels; LUSC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg11279151 chr3:101281821 RG9MTD1 -0.4 -5.85 -0.3 1.19e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9323205 0.953 rs7141012 chr14:51600948 C/G cg23942311 chr14:51606299 NA -0.47 -9.11 -0.45 7.51e-18 Cancer; LUSC trans rs877282 0.891 rs11253355 chr10:768367 C/G cg13042288 chr15:90349979 ANPEP -0.48 -6.93 -0.35 2.21e-11 Uric acid levels; LUSC cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs6681460 0.899 rs1280280 chr1:67173903 G/A cg02459107 chr1:67143332 SGIP1 0.46 8.53 0.42 5.14e-16 Presence of antiphospholipid antibodies; LUSC cis rs921665 0.680 rs7591433 chr2:3180126 A/C cg16434511 chr2:3151078 NA -0.64 -6.86 -0.35 3.31e-11 World class endurance athleticism; LUSC cis rs6120849 0.586 rs2025096 chr20:33540000 G/A cg24642439 chr20:33292090 TP53INP2 0.62 7.08 0.36 8.72e-12 Protein C levels; LUSC cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg04850211 chr1:228464232 OBSCN 0.31 5.68 0.3 2.95e-8 Diastolic blood pressure; LUSC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg01416388 chr22:39784598 NA -0.43 -7.27 -0.37 2.56e-12 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.49 8.16 0.41 6.89e-15 Intelligence (multi-trait analysis); LUSC trans rs7746199 0.736 rs35037868 chr6:27759115 G/C cg06606381 chr12:133084897 FBRSL1 -0.97 -8.42 -0.42 1.13e-15 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9948 0.655 rs6758151 chr2:97388884 A/G cg01990225 chr2:97406019 LMAN2L -1.09 -8.29 -0.41 2.9e-15 Erectile dysfunction and prostate cancer treatment; LUSC trans rs953492 0.591 rs10803123 chr1:243377892 T/A cg25284624 chr1:224180302 NA -0.43 -6.63 -0.34 1.35e-10 Diastolic blood pressure; LUSC cis rs5769707 0.837 rs1573726 chr22:50032872 G/A cg08680598 chr22:49984980 NA -0.33 -6.14 -0.32 2.39e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg02117656 chr17:79614917 TSPAN10 -0.31 -5.82 -0.3 1.41e-8 Eye color traits; LUSC cis rs877282 0.853 rs10904545 chr10:757100 G/A cg17470449 chr10:769945 NA 0.51 6.9 0.35 2.59e-11 Uric acid levels; LUSC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.57 7.47 0.38 7.22e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1670533 1.000 rs10003009 chr4:1050849 G/A cg19318889 chr4:1322082 MAEA 0.43 5.73 0.3 2.28e-8 Recombination rate (females); LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.75e-17 Prudent dietary pattern; LUSC cis rs6430585 0.583 rs12472293 chr2:136648077 T/C cg07169764 chr2:136633963 MCM6 1.23 19.09 0.72 1.82e-55 Corneal structure; LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg05025164 chr4:1340916 KIAA1530 0.41 6.11 0.32 2.8e-9 Obesity-related traits; LUSC cis rs4555082 0.957 rs8022526 chr14:105756485 A/G cg10792982 chr14:105748885 BRF1 0.43 7.6 0.38 2.94e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs2346177 0.844 rs12991646 chr2:46643831 A/G cg02822958 chr2:46747628 ATP6V1E2 0.36 6.23 0.32 1.43e-9 HDL cholesterol; LUSC cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.16 0.55 2.03e-28 Motion sickness; LUSC cis rs889512 0.731 rs3743614 chr16:75280958 C/T cg04987608 chr16:75300043 BCAR1 -0.54 -6.54 -0.34 2.26e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12971120 1.000 rs734559 chr18:72179579 G/A cg26446133 chr18:72167187 CNDP2 -0.79 -10.43 -0.5 3.06e-22 Refractive error; LUSC cis rs1728785 0.786 rs1728770 chr16:68564124 G/C cg02972257 chr16:68554789 NA -0.5 -6.36 -0.33 6.76e-10 Ulcerative colitis; LUSC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg11342453 chr6:26196699 NA -0.54 -5.73 -0.3 2.27e-8 Gout;Renal underexcretion gout; LUSC cis rs10927875 0.632 rs10927864 chr1:16165661 C/G cg21385522 chr1:16154831 NA -1.02 -20.77 -0.75 4.34e-62 Dilated cardiomyopathy; LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg25036284 chr2:26402008 FAM59B 0.72 10.36 0.49 5.33e-22 Gut microbiome composition (summer); LUSC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg13206674 chr6:150067644 NUP43 0.62 10.01 0.48 8.43e-21 Lung cancer; LUSC cis rs7481584 0.624 rs436580 chr11:3063961 T/G cg25174290 chr11:3078921 CARS -0.4 -5.92 -0.31 7.88e-9 Calcium levels; LUSC cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg23711669 chr6:146136114 FBXO30 0.86 15.36 0.64 1.19e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC cis rs7789940 0.904 rs12531348 chr7:75937191 G/C cg10167463 chr7:75959203 YWHAG -0.59 -8.48 -0.42 7.37e-16 Multiple sclerosis; LUSC cis rs4665809 0.590 rs11126339 chr2:26253223 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.94 -0.44 2.73e-17 Gut microbiome composition (summer); LUSC cis rs10089 0.857 rs7718286 chr5:127459414 G/C cg19767477 chr5:127420684 SLC12A2 -0.43 -5.7 -0.3 2.58e-8 Ileal carcinoids; LUSC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.96 0.51 4.45e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs72781680 1.000 rs12614452 chr2:24194608 C/T cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs921665 0.680 rs76494865 chr2:3191204 G/A cg02624386 chr2:3182749 NA 0.59 6.61 0.34 1.56e-10 World class endurance athleticism; LUSC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg14668632 chr7:2872130 GNA12 -0.42 -6.15 -0.32 2.26e-9 Height; LUSC cis rs9837602 0.935 rs9875640 chr3:99729091 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.21 0.32 1.57e-9 Breast cancer; LUSC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg24829409 chr8:58192753 C8orf71 -0.56 -6.39 -0.33 5.61e-10 Developmental language disorder (linguistic errors); LUSC cis rs9311676 0.632 rs62258126 chr3:58396114 T/C cg26110898 chr3:58419937 PDHB 0.4 6.42 0.33 4.6e-10 Systemic lupus erythematosus; LUSC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg13206674 chr6:150067644 NUP43 0.6 9.53 0.46 3.38e-19 Lung cancer; LUSC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg11871910 chr12:69753446 YEATS4 0.95 17.8 0.7 2.59e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs2273669 0.667 rs114481082 chr6:109280932 G/A cg05315195 chr6:109294784 ARMC2 -0.59 -6.61 -0.34 1.55e-10 Prostate cancer; LUSC cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs11252926 0.527 rs11252754 chr10:538637 G/A cg18196295 chr10:418757 DIP2C 0.36 5.65 0.3 3.44e-8 Psychosis in Alzheimer's disease; LUSC cis rs11645898 0.935 rs4788611 chr16:72175256 A/G cg14768367 chr16:72042858 DHODH -0.65 -7.11 -0.36 7.28e-12 Blood protein levels; LUSC cis rs7523050 0.730 rs12726126 chr1:109436128 A/G cg08274380 chr1:109419600 GPSM2 1.13 11.51 0.53 4.76e-26 Fat distribution (HIV); LUSC cis rs1018836 0.786 rs10086401 chr8:91572818 C/T cg16814680 chr8:91681699 NA -0.69 -11.08 -0.52 1.61e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg09323728 chr8:95962352 TP53INP1 -0.4 -7.93 -0.4 3.44e-14 Type 2 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg19518383 chr11:64577818 MEN1 -0.43 -6.21 -0.32 1.58e-9 Hepatitis; LUSC cis rs1322512 0.876 rs1159357 chr6:153029300 G/A cg27316956 chr6:152958899 SYNE1 0.35 5.85 0.3 1.16e-8 Tonometry; LUSC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg23788917 chr6:8435910 SLC35B3 0.51 7.56 0.38 3.85e-13 Motion sickness; LUSC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Melanoma; LUSC cis rs4851313 0.527 rs10183150 chr2:100939117 A/G cg12002119 chr2:101014098 CHST10 0.35 5.88 0.31 1.02e-8 Intelligence (multi-trait analysis); LUSC cis rs6942756 1.000 rs12111832 chr7:128889025 G/C cg02491457 chr7:128862824 NA -0.52 -7.42 -0.38 9.94e-13 White matter hyperintensity burden; LUSC cis rs12594515 1.000 rs8029209 chr15:45993489 A/G cg06207120 chr15:45996521 NA 0.38 5.71 0.3 2.53e-8 Waist circumference;Weight; LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.79 0.78 5.11e-70 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg03678062 chr6:149772716 ZC3H12D 0.3 6.22 0.32 1.45e-9 Dupuytren's disease; LUSC trans rs8002861 0.810 rs2275252 chr13:44454374 A/C cg12856521 chr11:46389249 DGKZ 0.42 6.53 0.34 2.48e-10 Leprosy; LUSC cis rs2742417 0.624 rs2673029 chr3:45758867 A/G cg04837898 chr3:45731254 SACM1L -0.42 -6.82 -0.35 4.36e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1865721 0.771 rs72975985 chr18:73127648 C/T cg26385618 chr18:73139727 C18orf62 -0.54 -9.7 -0.47 8.93e-20 Intelligence; LUSC cis rs926938 0.618 rs6693491 chr1:115371061 A/G cg12756093 chr1:115239321 AMPD1 -0.53 -8.06 -0.4 1.42e-14 Autism; LUSC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg10556349 chr10:835070 NA 0.56 6.44 0.33 4.08e-10 Eosinophil percentage of granulocytes; LUSC trans rs1347297 0.614 rs7589679 chr2:179282437 T/C cg14011486 chr1:26737247 LIN28 0.46 7.18 0.37 4.57e-12 Alzheimer disease and age of onset; LUSC cis rs56283067 0.578 rs12201563 chr6:45359394 T/C cg20913747 chr6:44695427 NA -0.46 -6.72 -0.35 7.77e-11 Total body bone mineral density; LUSC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.68 0.3 2.9e-8 Self-reported allergy; LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg24642844 chr7:1081250 C7orf50 -0.81 -10.91 -0.51 6.82e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg05347473 chr6:146136440 FBXO30 0.55 9.44 0.46 6.44e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs8017423 0.904 rs11848894 chr14:90723660 C/A cg04374321 chr14:90722782 PSMC1 0.75 12.08 0.55 4e-28 Mortality in heart failure; LUSC cis rs6545883 0.708 rs2518936 chr2:61792342 T/C cg15711740 chr2:61764176 XPO1 -0.39 -6.15 -0.32 2.17e-9 Tuberculosis; LUSC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg02931644 chr1:25747376 RHCE 0.37 6.81 0.35 4.45e-11 Plateletcrit;Mean corpuscular volume; LUSC trans rs2243480 1.000 rs419603 chr7:65597341 C/T cg10756647 chr7:56101905 PSPH 0.84 8.72 0.43 1.32e-16 Diabetic kidney disease; LUSC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg11941060 chr3:133502564 NA -0.5 -7.79 -0.39 8.43e-14 Iron status biomarkers; LUSC cis rs7568458 0.660 rs2289972 chr2:85766545 C/T cg23752985 chr2:85803571 VAMP8 0.33 6.38 0.33 5.92e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.53 -7.22 -0.37 3.47e-12 Mean platelet volume; LUSC cis rs2625529 0.617 rs11630170 chr15:72448451 C/T cg16672083 chr15:72433130 SENP8 0.5 8.07 0.4 1.29e-14 Red blood cell count; LUSC cis rs1577917 0.637 rs1838957 chr6:86565056 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.29 -0.33 9.98e-10 Response to antipsychotic treatment; LUSC cis rs60843830 1.000 rs114976176 chr2:264621 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.63 0.39 2.49e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg11244672 chr19:19639970 YJEFN3 0.64 8.0 0.4 2.09e-14 Bipolar disorder; LUSC trans rs11098499 0.644 rs10050092 chr4:120532085 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.42 6.12 0.32 2.69e-9 Corneal astigmatism; LUSC cis rs11250464 0.755 rs11250468 chr10:1410060 A/G cg26394196 chr10:1453818 ADARB2 -0.37 -6.36 -0.33 6.48e-10 Radiation response; LUSC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg22166914 chr1:53195759 ZYG11B 0.66 11.12 0.52 1.2e-24 Monocyte count; LUSC cis rs7833986 0.501 rs2953909 chr8:56968200 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.54 0.57 7.75e-30 Height; LUSC cis rs8049634 0.720 rs11864916 chr16:84228305 C/G cg07804857 chr16:84208222 LRRC50 -0.32 -5.9 -0.31 8.84e-9 Small cell lung carcinoma; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg16606324 chr3:10149918 C3orf24 0.62 9.06 0.44 1.15e-17 Alzheimer's disease; LUSC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg18350739 chr11:68623251 NA -0.38 -6.38 -0.33 5.75e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11792861 0.816 rs28361111 chr9:111761012 A/C cg05043794 chr9:111880884 C9orf5 -0.38 -7.88 -0.4 4.51e-14 Menarche (age at onset); LUSC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg16680214 chr1:154839983 KCNN3 0.45 8.11 0.41 9.58e-15 Prostate cancer; LUSC cis rs61931739 0.853 rs10844751 chr12:34099651 T/G cg06521331 chr12:34319734 NA 0.38 6.4 0.33 5.32e-10 Morning vs. evening chronotype; LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg11843238 chr5:131593191 PDLIM4 -0.38 -6.18 -0.32 1.87e-9 Blood metabolite levels; LUSC cis rs793571 0.566 rs1648532 chr15:59076778 G/C cg05156742 chr15:59063176 FAM63B 0.56 8.44 0.42 9.48e-16 Schizophrenia; LUSC cis rs7267979 0.966 rs2387882 chr20:25378802 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs734999 0.505 rs4648659 chr1:2560903 T/G cg18932078 chr1:2524107 MMEL1 -0.31 -6.84 -0.35 3.79e-11 Ulcerative colitis; LUSC trans rs6502050 0.835 rs3924781 chr17:80113130 T/C cg07393940 chr7:158741817 NA 0.37 6.58 0.34 1.84e-10 Life satisfaction; LUSC cis rs8062405 0.929 rs11864750 chr16:28875204 A/T cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2795502 1.000 rs2142991 chr10:43341105 C/T cg20628663 chr10:43360327 NA -0.77 -11.37 -0.53 1.57e-25 Blood protein levels; LUSC cis rs1113500 0.933 rs1419003 chr1:108616955 A/C cg11967332 chr1:108735228 SLC25A24 0.4 5.88 0.31 1.01e-8 Growth-regulated protein alpha levels; LUSC cis rs7772486 0.558 rs2142980 chr6:146080679 G/A cg13319975 chr6:146136371 FBXO30 0.67 9.48 0.46 5.01e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.605 rs2071900 chr22:50052175 A/G cg20744362 chr22:50050164 C22orf34 0.39 7.29 0.37 2.27e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8072100 0.745 rs7214410 chr17:45422628 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.35 -5.67 -0.3 3.06e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1372520 0.684 rs2583968 chr4:90745395 C/G cg15133208 chr4:90757351 SNCA -0.53 -8.1 -0.41 1.04e-14 Neuroticism; LUSC cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg06784218 chr1:46089804 CCDC17 0.49 9.41 0.46 8.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs477692 1.000 rs513736 chr10:131406489 C/T cg05714579 chr10:131428358 MGMT 0.49 7.39 0.37 1.21e-12 Response to temozolomide; LUSC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs17767294 0.708 rs72848754 chr6:27878458 T/A cg08851530 chr6:28072375 NA 1.31 8.29 0.41 2.8e-15 Parkinson's disease; LUSC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.2 0.61 3.9e-36 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9837602 0.872 rs34996634 chr3:99738219 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg12463550 chr7:65579703 CRCP 0.5 6.99 0.36 1.46e-11 Aortic root size; LUSC cis rs4648739 0.613 rs13303201 chr1:1903712 G/T cg04624458 chr1:1913527 KIAA1751 0.36 5.97 0.31 6.12e-9 Severe influenza A (H1N1) infection; LUSC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.47 4.43e-20 Eye color traits; LUSC cis rs9911578 0.835 rs3744093 chr17:56492800 T/C cg05425664 chr17:57184151 TRIM37 0.56 8.5 0.42 6.49e-16 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg12257692 chr3:49977190 RBM6 -0.25 -7.14 -0.36 5.92e-12 Body mass index; LUSC trans rs1376359 0.503 rs584481 chr1:103250184 T/C cg17154563 chr19:40477487 PSMC4 0.48 6.04 0.31 4.03e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs55665837 0.961 rs12795972 chr11:14443775 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs11247915 0.501 rs34209692 chr1:26608782 C/T cg04990556 chr1:26633338 UBXN11 -0.53 -7.24 -0.37 3.15e-12 Obesity-related traits; LUSC cis rs11105298 0.891 rs8181784 chr12:89828591 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.47 -6.57 -0.34 1.93e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg21782813 chr7:2030301 MAD1L1 0.55 9.98 0.48 1.04e-20 Bipolar disorder and schizophrenia; LUSC cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg06462663 chr19:18546047 ISYNA1 0.48 8.16 0.41 6.81e-15 Breast cancer; LUSC cis rs868036 1.000 rs9972436 chr15:68098027 G/C cg08079166 chr15:68083412 MAP2K5 0.4 8.32 0.41 2.2e-15 Restless legs syndrome; LUSC cis rs367615 0.506 rs2914684 chr5:108775110 C/T cg17395555 chr5:108820864 NA -0.52 -9.75 -0.47 6.13e-20 Colorectal cancer (SNP x SNP interaction); LUSC cis rs7712401 0.791 rs6595409 chr5:122113756 G/A cg19077854 chr5:122220652 SNX24 0.35 7.87 0.4 5.01e-14 Mean platelet volume; LUSC cis rs2303282 0.664 rs2440472 chr16:56436824 A/G cg00500540 chr16:56394104 NA -0.39 -6.69 -0.34 9.34e-11 Breast cancer; LUSC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg20243544 chr17:37824526 PNMT 0.58 8.26 0.41 3.46e-15 Asthma; LUSC cis rs5769765 0.817 rs11912619 chr22:50317401 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.7 -0.51 3.49e-23 Schizophrenia; LUSC cis rs1018836 0.828 rs756568 chr8:91557038 G/C cg16814680 chr8:91681699 NA -0.69 -11.18 -0.52 7.13e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.16 0.45 5.48e-18 Menarche (age at onset); LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg15790184 chr11:494944 RNH1 0.54 6.17 0.32 1.96e-9 Body mass index; LUSC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg09263875 chr16:632152 PIGQ 0.71 13.18 0.59 3.08e-32 Height; LUSC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg05368731 chr17:41323189 NBR1 0.83 13.39 0.59 4.9e-33 Menopause (age at onset); LUSC cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg07828340 chr4:882639 GAK 1.07 11.42 0.53 1.01e-25 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg03188948 chr7:1209495 NA 0.41 6.05 0.31 3.92e-9 Longevity;Endometriosis; LUSC cis rs1008375 0.900 rs13144986 chr4:17675019 C/A cg04450456 chr4:17643702 FAM184B -0.41 -6.67 -0.34 1.06e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3849570 0.555 rs6790351 chr3:82008988 C/T cg07356753 chr3:81810745 GBE1 -0.42 -6.07 -0.32 3.41e-9 Waist circumference;Body mass index; LUSC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg24578937 chr1:2090814 PRKCZ -0.42 -9.13 -0.45 6.71e-18 Height; LUSC cis rs12681287 0.640 rs12541793 chr8:87462558 G/A cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg17063962 chr7:91808500 NA -0.59 -9.29 -0.45 1.98e-18 Breast cancer; LUSC cis rs713587 0.571 rs475868 chr2:25318059 A/G cg01884057 chr2:25150051 NA -0.26 -5.72 -0.3 2.31e-8 Body mass index in non-asthmatics; LUSC cis rs2677744 0.626 rs868547 chr15:91498760 G/A cg20750528 chr15:91474456 HDDC3;UNC45A -0.32 -5.65 -0.3 3.37e-8 Attention deficit hyperactivity disorder; LUSC cis rs10743315 0.643 rs12578443 chr12:19321893 G/C cg02471346 chr12:19282374 PLEKHA5 0.67 6.74 0.35 7.07e-11 Gut microbiota (bacterial taxa); LUSC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg09904177 chr6:26538194 HMGN4 -0.5 -5.78 -0.3 1.74e-8 Intelligence (multi-trait analysis); LUSC cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg05855489 chr10:104503620 C10orf26 0.59 9.61 0.47 1.81e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg12011299 chr4:100065546 ADH4 0.71 10.81 0.51 1.48e-23 Smoking initiation; LUSC cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.82 0.3 1.41e-8 Breast cancer; LUSC cis rs7481584 0.624 rs377765 chr11:3046298 C/T cg05729581 chr11:3078854 CARS 0.4 5.97 0.31 6.03e-9 Calcium levels; LUSC cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.53 0.42 5.16e-16 Motion sickness; LUSC cis rs981844 0.857 rs41320045 chr4:154720615 A/T cg10279832 chr4:154682576 RNF175 0.39 5.86 0.31 1.11e-8 Response to statins (LDL cholesterol change); LUSC cis rs1692580 0.870 rs263532 chr1:2164116 T/C cg21194808 chr1:2205498 SKI 0.36 5.76 0.3 1.91e-8 Coronary artery disease; LUSC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg14829155 chr15:31115871 NA -0.72 -10.7 -0.51 3.74e-23 Huntington's disease progression; LUSC cis rs75804782 0.641 rs60841092 chr2:239349640 G/A cg18131467 chr2:239335373 ASB1 -0.75 -6.67 -0.34 1.04e-10 Morning vs. evening chronotype;Chronotype; LUSC trans rs7824557 0.527 rs2572446 chr8:11239565 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.48 -0.38 6.57e-13 Retinal vascular caliber; LUSC cis rs9398803 0.865 rs9398809 chr6:126789144 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.9e-9 Male-pattern baldness; LUSC cis rs4660306 0.961 rs4660864 chr1:45966582 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -7.01 -0.36 1.33e-11 Homocysteine levels; LUSC cis rs2286885 1.000 rs2286886 chr9:129246177 T/C cg15282417 chr9:129245246 FAM125B 0.38 6.34 0.33 7.26e-10 Intraocular pressure; LUSC cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg04455712 chr21:45112962 RRP1B 0.42 7.94 0.4 3.02e-14 Mean corpuscular volume; LUSC trans rs1941687 0.583 rs8091977 chr18:31359414 T/C cg27147174 chr7:100797783 AP1S1 -0.52 -8.28 -0.41 3.04e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs8078723 1.000 rs56922390 chr17:38157021 C/G cg17467752 chr17:38218738 THRA 0.77 12.47 0.56 1.47e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg03676636 chr4:99064102 C4orf37 0.36 7.92 0.4 3.52e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs8141529 0.702 rs469991 chr22:29307859 G/C cg02153584 chr22:29168773 CCDC117 -0.58 -8.72 -0.43 1.3e-16 Lymphocyte counts; LUSC cis rs67072384 1.000 rs5008485 chr11:72455152 C/T cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs28655083 0.843 rs1502433 chr16:77087101 C/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 7.08 0.36 8.57e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg23758822 chr17:41437982 NA 1.01 19.87 0.74 1.5e-58 Menopause (age at onset); LUSC cis rs7005380 0.556 rs4073559 chr8:120917443 G/C cg21744203 chr8:120868354 DSCC1 -0.48 -5.84 -0.3 1.26e-8 Interstitial lung disease; LUSC cis rs11155671 0.530 rs7774787 chr6:150209432 G/A cg09699651 chr6:150184138 LRP11 0.46 7.27 0.37 2.54e-12 Testicular germ cell tumor; LUSC cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg13010199 chr12:38710504 ALG10B 0.68 10.65 0.5 5.32e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg18477163 chr1:228402036 OBSCN -0.55 -10.16 -0.49 2.62e-21 Diastolic blood pressure; LUSC cis rs1670533 0.746 rs688008 chr4:1082829 T/C cg27284194 chr4:1044797 NA 0.59 8.79 0.43 7.77e-17 Recombination rate (females); LUSC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg06219351 chr7:158114137 PTPRN2 0.49 8.85 0.44 5.26e-17 Calcium levels; LUSC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg18404041 chr3:52824283 ITIH1 -0.57 -9.6 -0.46 2.04e-19 Schizophrenia; LUSC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg05347473 chr6:146136440 FBXO30 0.65 11.39 0.53 1.29e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs9467711 0.516 rs1165163 chr6:25863487 G/C cg08501292 chr6:25962987 TRIM38 0.57 5.9 0.31 8.86e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs1044826 0.553 rs295469 chr3:139212900 G/A cg00490450 chr3:139108681 COPB2 0.43 6.2 0.32 1.67e-9 Obesity-related traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21864845 chr1:1208426 UBE2J2 0.47 6.75 0.35 6.44e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7312933 0.558 rs4768402 chr12:42755576 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.89 -0.35 2.8e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.63 -13.8 -0.6 1.3600000000000001e-34 Hemoglobin concentration; LUSC trans rs7181230 1.000 rs7181230 chr15:40360741 A/G cg22705835 chr10:65332833 REEP3 -0.43 -7.68 -0.39 1.76e-13 Dehydroepiandrosterone sulphate levels; LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg18404041 chr3:52824283 ITIH1 -0.62 -12.3 -0.56 6.21e-29 Bipolar disorder; LUSC cis rs4906332 1.000 rs17617307 chr14:103904965 C/G cg04998671 chr14:104000505 TRMT61A -0.44 -6.85 -0.35 3.48e-11 Coronary artery disease; LUSC cis rs9815354 0.812 rs113528686 chr3:41951547 T/C cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg25319279 chr11:5960081 NA -0.39 -6.19 -0.32 1.76e-9 DNA methylation (variation); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg17746833 chr17:39805051 NA 0.39 6.13 0.32 2.48e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7851660 0.935 rs10818124 chr9:100603008 C/T cg13688889 chr9:100608707 NA -0.61 -10.38 -0.49 4.54e-22 Strep throat; LUSC cis rs7824557 0.527 rs4634600 chr8:11239017 T/A cg21775007 chr8:11205619 TDH -0.64 -10.41 -0.49 3.61e-22 Retinal vascular caliber; LUSC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.79 -0.35 5.15e-11 Intelligence (multi-trait analysis); LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg09877947 chr5:131593287 PDLIM4 0.51 7.94 0.4 3.2e-14 Acylcarnitine levels; LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg09469691 chr10:81107165 PPIF 0.67 10.56 0.5 1.12e-22 Height; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg12442385 chr7:1034912 NA -0.34 -5.84 -0.3 1.21e-8 Longevity;Endometriosis; LUSC cis rs1775715 0.677 rs2808105 chr10:32110907 C/T cg26784012 chr10:32216390 ARHGAP12 0.44 7.39 0.37 1.21e-12 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs11610422 1.000 rs12824814 chr12:31414473 G/T cg02734259 chr12:9559402 NA -0.6 -6.39 -0.33 5.69e-10 Coronary artery disease; LUSC cis rs9611565 0.921 rs2143695 chr22:41728620 A/G cg03806693 chr22:41940476 POLR3H -0.7 -10.03 -0.48 7.22e-21 Vitiligo; LUSC cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg04727924 chr7:799746 HEATR2 -0.54 -6.46 -0.33 3.79e-10 Cerebrospinal P-tau181p levels; LUSC cis rs12137294 0.866 rs1077883 chr1:205210415 G/T cg00857998 chr1:205179979 DSTYK 0.39 5.73 0.3 2.25e-8 Red cell distribution width; LUSC cis rs7267979 1.000 rs2259873 chr20:25280781 A/G cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs950027 0.620 rs1145089 chr15:45652054 G/C cg04036182 chr15:45458818 NA 0.35 5.75 0.3 2.02e-8 Response to fenofibrate (adiponectin levels); LUSC trans rs7769051 1.000 rs7769051 chr6:133146796 G/T cg27275811 chr11:74457193 NA -0.61 -6.15 -0.32 2.17e-9 Type 2 diabetes nephropathy; LUSC cis rs3820068 0.705 rs4646091 chr1:15822043 T/C cg17385448 chr1:15911702 AGMAT 0.37 5.86 0.31 1.08e-8 Systolic blood pressure; LUSC cis rs8081395 0.769 rs12449331 chr17:57883646 T/C cg18434674 chr17:58106139 NA -0.27 -5.92 -0.31 8.01e-9 White blood cell count; LUSC cis rs965469 1.000 rs6051702 chr20:3251924 A/C cg25506879 chr20:3388711 C20orf194 -0.54 -6.28 -0.33 1.04e-9 IFN-related cytopenia; LUSC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3820928 0.874 rs13383070 chr2:227904939 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.87 -0.4 5.01e-14 Pulmonary function; LUSC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg18876405 chr7:65276391 NA 0.7 12.59 0.57 5.27e-30 Aortic root size; LUSC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.63 -0.34 1.33e-10 Alzheimer's disease (late onset); LUSC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg02772935 chr3:125709198 NA -0.48 -5.76 -0.3 1.94e-8 Blood pressure (smoking interaction); LUSC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.1 -0.41 1.07e-14 Lung cancer; LUSC trans rs877282 0.735 rs111609055 chr10:826539 A/G cg13042288 chr15:90349979 ANPEP -0.4 -6.02 -0.31 4.53e-9 Uric acid levels; LUSC cis rs7615952 0.932 rs1976458 chr3:125647512 T/G cg02807482 chr3:125708958 NA -0.49 -5.79 -0.3 1.61e-8 Blood pressure (smoking interaction); LUSC cis rs7804356 1.000 rs3801833 chr7:26852212 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg22117172 chr7:91764530 CYP51A1 0.33 5.83 0.3 1.28e-8 Breast cancer; LUSC cis rs4240897 0.935 rs2236055 chr1:12042261 A/G cg13216073 chr1:12042593 MFN2 0.42 7.56 0.38 3.88e-13 Tuberculosis; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg08128889 chr17:80828176 TBCD -0.45 -7.12 -0.36 6.82e-12 N-glycan levels; LUSC cis rs722599 0.683 rs2058918 chr14:75288518 A/G cg08847533 chr14:75593920 NEK9 0.43 5.97 0.31 6.06e-9 IgG glycosylation; LUSC cis rs79149102 0.737 rs75128970 chr15:75181397 C/T cg09165964 chr15:75287851 SCAMP5 -0.88 -6.53 -0.34 2.48e-10 Lung cancer; LUSC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs79149102 0.579 rs7342601 chr15:75306795 G/T cg09165964 chr15:75287851 SCAMP5 0.85 8.01 0.4 1.89e-14 Lung cancer; LUSC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg04518342 chr5:131593106 PDLIM4 0.4 7.31 0.37 1.94e-12 Breast cancer; LUSC cis rs2404602 0.591 rs11635162 chr15:76951105 C/T cg23625390 chr15:77176239 SCAPER -0.62 -8.81 -0.43 7.12e-17 Blood metabolite levels; LUSC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg04398451 chr17:18023971 MYO15A 0.46 7.32 0.37 1.81e-12 Total body bone mineral density; LUSC cis rs7560272 0.723 rs780391 chr2:73703904 C/T cg20560298 chr2:73613845 ALMS1 0.45 7.14 0.36 5.99e-12 Schizophrenia; LUSC cis rs7103648 0.808 rs7103835 chr11:47461693 G/A cg20307385 chr11:47447363 PSMC3 0.88 13.69 0.6 3.44e-34 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs25645 0.830 rs3935281 chr17:38188419 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.66 11.36 0.53 1.63e-25 Myeloid white cell count; LUSC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg06636001 chr8:8085503 FLJ10661 0.59 9.08 0.45 9.34e-18 Mood instability; LUSC cis rs1595825 1.000 rs73058821 chr2:198864597 A/G cg19156104 chr2:198669113 PLCL1 -0.46 -5.71 -0.3 2.44e-8 Ulcerative colitis; LUSC cis rs9515201 0.774 rs9521739 chr13:111038803 A/G cg05272587 chr13:111038400 COL4A2 -0.35 -5.71 -0.3 2.52e-8 White matter hyperintensity burden; LUSC cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg05347473 chr6:146136440 FBXO30 0.52 8.82 0.43 6.43e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg12564285 chr5:131593104 PDLIM4 -0.33 -6.0 -0.31 5.18e-9 Breast cancer;Mosquito bite size; LUSC trans rs72674100 0.737 rs2865752 chr4:97992784 T/C cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg15423357 chr2:25149977 NA 0.45 9.02 0.44 1.52e-17 Body mass index; LUSC cis rs4356932 0.935 rs115936805 chr4:76968068 C/T cg00809888 chr4:76862425 NAAA 0.35 5.86 0.31 1.11e-8 Blood protein levels; LUSC cis rs3772130 0.564 rs4420917 chr3:121567863 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.83 13.54 0.6 1.29e-33 Cognitive performance; LUSC cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg23649088 chr2:200775458 C2orf69 0.59 7.35 0.37 1.56e-12 Schizophrenia; LUSC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg09044154 chr16:88155775 NA -0.55 -7.36 -0.37 1.48e-12 Menopause (age at onset); LUSC cis rs9399135 0.660 rs4472368 chr6:135274232 A/G cg24558204 chr6:135376177 HBS1L 0.55 8.34 0.42 2.02e-15 Red blood cell count; LUSC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.87 14.63 0.62 8.8e-38 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4919694 1.000 rs77505796 chr10:104647774 A/T cg04362960 chr10:104952993 NT5C2 1.18 13.48 0.59 2.26e-33 Arsenic metabolism; LUSC cis rs6121246 0.560 rs6088854 chr20:30225357 G/A cg21427119 chr20:30132790 HM13 -0.46 -6.38 -0.33 5.78e-10 Mean corpuscular hemoglobin; LUSC trans rs4450131 0.522 rs17152232 chr10:126398927 A/G cg09091424 chr11:67057304 ANKRD13D 0.42 6.07 0.32 3.5e-9 White blood cell count (basophil); LUSC cis rs9790314 0.540 rs35462273 chr3:160991877 C/T cg03342759 chr3:160939853 NMD3 -0.54 -7.92 -0.4 3.48e-14 Morning vs. evening chronotype; LUSC cis rs4919087 0.962 rs3740522 chr10:99019144 C/T cg25902810 chr10:99078978 FRAT1 0.46 6.57 0.34 1.9e-10 Monocyte count; LUSC cis rs11098499 0.863 rs12502389 chr4:120454191 A/G cg09307838 chr4:120376055 NA 0.73 10.28 0.49 1.02e-21 Corneal astigmatism; LUSC cis rs765787 0.530 rs11858988 chr15:45522114 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.82 -0.43 6.55e-17 Uric acid levels; LUSC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg26408565 chr15:76604113 ETFA -0.48 -7.69 -0.39 1.64e-13 Blood metabolite levels; LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg27170947 chr2:26402098 FAM59B 0.72 10.82 0.51 1.41e-23 Gut microbiome composition (summer); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04275194 chr2:219433691 USP37;RQCD1 0.45 7.71 0.39 1.48e-13 Triglycerides; LUSC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg16928487 chr17:17741425 SREBF1 0.37 7.13 0.36 6.28e-12 Total body bone mineral density; LUSC cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg23158103 chr7:148848205 ZNF398 -0.5 -8.17 -0.41 6.41e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg17892150 chr10:133769511 PPP2R2D -0.67 -9.25 -0.45 2.85e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs5769765 0.908 rs138889 chr22:50226673 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.79 -10.34 -0.49 6.48e-22 Schizophrenia; LUSC cis rs877282 0.898 rs11253352 chr10:766598 C/A cg17470449 chr10:769945 NA 0.53 7.41 0.38 1.05e-12 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27585405 chr16:475496 RAB11FIP3 -0.41 -6.08 -0.32 3.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12208915 0.559 rs4706738 chr6:79514153 A/G cg09184832 chr6:79620586 NA 0.43 6.63 0.34 1.35e-10 Left atrial antero-posterior diameter; LUSC cis rs7789940 0.904 rs61294900 chr7:75937212 A/T cg10167463 chr7:75959203 YWHAG -0.59 -8.48 -0.42 7.37e-16 Multiple sclerosis; LUSC cis rs9649213 0.574 rs17436977 chr7:97883459 T/C cg26380479 chr7:97908229 NA -0.27 -5.81 -0.3 1.44e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs6596100 0.554 rs12515756 chr5:132238880 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.29 -0.33 9.7e-10 Breast cancer; LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs10140922 0.864 rs72666622 chr14:35820138 T/A cg07166546 chr14:35805898 NA -0.26 -6.11 -0.32 2.76e-9 Hip circumference adjusted for BMI; LUSC cis rs9644630 0.696 rs35736969 chr8:19319620 G/A cg06562184 chr8:19319451 CSGALNACT1 0.5 8.2 0.41 5.3e-15 Oropharynx cancer; LUSC cis rs67072384 0.892 rs7104664 chr11:72444450 C/T cg04827223 chr11:72435913 ARAP1 -0.82 -7.76 -0.39 1.04e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs34779708 0.931 rs3740083 chr10:35320383 C/T cg04310649 chr10:35416472 CREM -0.4 -6.07 -0.32 3.45e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs965513 1.000 rs1443438 chr9:100550028 T/C cg13688889 chr9:100608707 NA -0.54 -7.97 -0.4 2.58e-14 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs4660306 0.884 rs7543076 chr1:45964238 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.15 -0.36 5.48e-12 Homocysteine levels; LUSC trans rs9929218 0.954 rs9646284 chr16:68791306 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -11.29 -0.53 2.99e-25 Colorectal cancer; LUSC cis rs17095355 0.901 rs9783184 chr10:111760499 T/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.35 -0.37 1.53e-12 Biliary atresia; LUSC cis rs1577917 0.572 rs911927 chr6:86327860 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.72 -0.39 1.33e-13 Response to antipsychotic treatment; LUSC trans rs79976124 0.879 rs12214948 chr6:66633603 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 8.5 0.42 6.31e-16 Type 2 diabetes; LUSC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.2 0.32 1.7e-9 Multiple sclerosis; LUSC cis rs4363385 0.693 rs576941 chr1:153040165 A/G cg00922841 chr1:152955080 SPRR1A 0.42 7.31 0.37 1.97e-12 Inflammatory skin disease; LUSC cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg27398817 chr8:82754497 SNX16 0.6 7.43 0.38 9.41e-13 Diastolic blood pressure; LUSC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg22535103 chr8:58192502 C8orf71 -0.57 -6.72 -0.34 8.09e-11 Developmental language disorder (linguistic errors); LUSC cis rs10761482 0.861 rs7073512 chr10:62109926 T/G cg18175470 chr10:62150864 ANK3 -0.5 -7.05 -0.36 1.05e-11 Schizophrenia; LUSC cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg24642439 chr20:33292090 TP53INP2 0.5 7.46 0.38 7.71e-13 Height; LUSC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg02782426 chr3:40428986 ENTPD3 0.39 7.48 0.38 6.78e-13 Renal cell carcinoma; LUSC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg19468946 chr17:37922297 IKZF3 -0.44 -6.93 -0.35 2.22e-11 Self-reported allergy; LUSC cis rs10761482 0.566 rs4505011 chr10:62200308 T/C cg18175470 chr10:62150864 ANK3 -0.54 -7.63 -0.39 2.45e-13 Schizophrenia; LUSC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg17330251 chr7:94953956 PON1 -0.36 -5.64 -0.3 3.57e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6429082 0.818 rs61836206 chr1:235638754 C/G cg26050004 chr1:235667680 B3GALNT2 0.62 8.43 0.42 1.02e-15 Adiposity; LUSC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg06212747 chr3:49208901 KLHDC8B 0.44 5.69 0.3 2.76e-8 Parkinson's disease; LUSC cis rs11048434 0.736 rs12821842 chr12:9108984 G/A cg04155231 chr12:9217510 LOC144571 0.3 5.68 0.3 2.93e-8 Sjögren's syndrome; LUSC cis rs2227564 0.729 rs2675674 chr10:75652682 G/A cg23231163 chr10:75533350 FUT11 -0.42 -5.92 -0.31 8.17e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9921338 0.961 rs9302459 chr16:11420339 G/T cg00044050 chr16:11439710 C16orf75 0.46 6.09 0.32 3.03e-9 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2348418 0.864 rs7304540 chr12:28713422 C/G cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.48e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs405956 0.932 rs9654624 chr6:105584895 G/C cg22580625 chr6:105627791 POPDC3 -0.59 -5.77 -0.3 1.84e-8 QT interval; LUSC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg04455712 chr21:45112962 RRP1B 0.44 8.33 0.41 2.17e-15 Mean corpuscular volume; LUSC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg13298116 chr11:62369859 EML3;MTA2 0.53 7.81 0.39 7.45e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg20203395 chr5:56204925 C5orf35 -0.77 -10.27 -0.49 1.12e-21 Initial pursuit acceleration; LUSC cis rs72829446 0.530 rs66616380 chr17:7380188 C/A cg02795151 chr17:7402630 POLR2A 0.61 7.4 0.38 1.13e-12 Androgen levels; LUSC cis rs4566357 1.000 rs7567789 chr2:227922104 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.76 -0.3 1.87e-8 Coronary artery disease; LUSC cis rs611744 0.647 rs9969614 chr8:109260581 A/G cg21045802 chr8:109455806 TTC35 0.43 6.56 0.34 2.08e-10 Dupuytren's disease; LUSC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg01652190 chr22:50026171 C22orf34 -0.31 -6.39 -0.33 5.51e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7914558 0.966 rs10748837 chr10:104880236 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.53 0.46 3.28e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg06481639 chr22:41940642 POLR3H -0.51 -6.17 -0.32 1.98e-9 Vitiligo; LUSC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg18876405 chr7:65276391 NA 0.56 8.89 0.44 3.85e-17 Aortic root size; LUSC trans rs7824557 0.602 rs11784544 chr8:11204503 G/C cg08975724 chr8:8085496 FLJ10661 0.43 6.09 0.32 3.06e-9 Retinal vascular caliber; LUSC cis rs4974559 0.501 rs1732115 chr4:1244416 C/T cg02980000 chr4:1222292 CTBP1 1.0 10.04 0.48 6.65e-21 Systolic blood pressure; LUSC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.77 0.3 1.81e-8 Cerebrospinal P-tau181p levels; LUSC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg06784218 chr1:46089804 CCDC17 -0.48 -9.21 -0.45 3.67e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1728785 0.901 rs698711 chr16:68561955 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.89 -0.31 9.61e-9 Ulcerative colitis; LUSC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg06022373 chr22:39101656 GTPBP1 0.84 13.98 0.61 2.65e-35 Menopause (age at onset); LUSC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg16447950 chr5:562315 NA -0.55 -6.63 -0.34 1.35e-10 Obesity-related traits; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -7.99 -0.4 2.23e-14 Lymphocyte counts; LUSC cis rs8014204 0.753 rs6574199 chr14:75356103 T/C cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.35 -0.53 1.82e-25 Caffeine consumption; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg27535305 chr1:53392650 SCP2 -0.41 -8.1 -0.41 1.05e-14 Monocyte count; LUSC cis rs4512344 0.509 rs2409784 chr8:11396856 G/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.26 -0.32 1.18e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg06600287 chr1:53387719 ECHDC2 -0.28 -5.69 -0.3 2.73e-8 Monocyte count; LUSC cis rs782590 0.620 rs7596377 chr2:55888612 T/A cg18811423 chr2:55921094 PNPT1 -0.69 -10.24 -0.49 1.4e-21 Metabolic syndrome; LUSC cis rs78545713 0.649 rs77727979 chr6:26222026 T/A cg23601095 chr6:26197514 HIST1H3D 0.67 5.68 0.3 2.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs11098499 0.863 rs13134665 chr4:120426430 T/C cg24375607 chr4:120327624 NA 0.76 11.36 0.53 1.69e-25 Corneal astigmatism; LUSC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.24e-8 Aortic root size; LUSC cis rs4363385 0.693 rs310102 chr1:153042423 T/C cg00922841 chr1:152955080 SPRR1A -0.42 -7.24 -0.37 3.13e-12 Inflammatory skin disease; LUSC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.93 17.64 0.69 1.13e-49 Body mass index (adult); LUSC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg02753203 chr1:228287806 NA 0.73 12.91 0.58 3.34e-31 Diastolic blood pressure; LUSC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg21028142 chr17:79581711 NPLOC4 -0.32 -7.79 -0.39 8.41e-14 Eye color traits; LUSC cis rs62458065 0.850 rs28693551 chr7:32469387 G/A cg20159608 chr7:32802032 NA -0.63 -7.5 -0.38 5.76e-13 Metabolite levels (HVA/MHPG ratio); LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg14433983 chr11:636460 DRD4 -0.35 -5.88 -0.31 9.78e-9 Systemic lupus erythematosus; LUSC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg24110177 chr3:50126178 RBM5 -0.67 -11.5 -0.53 5.03e-26 Body mass index; LUSC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11644478 chr21:40555479 PSMG1 -0.83 -15.1 -0.64 1.25e-39 Cognitive function; LUSC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg16797656 chr11:68205561 LRP5 0.36 6.06 0.31 3.66e-9 Total body bone mineral density; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg03354898 chr7:1950403 MAD1L1 0.35 6.85 0.35 3.55e-11 Bipolar disorder and schizophrenia; LUSC cis rs9399135 0.967 rs4896123 chr6:135295410 T/G cg22676075 chr6:135203613 NA 0.49 7.44 0.38 8.37e-13 Red blood cell count; LUSC trans rs1448094 0.817 rs12370270 chr12:86343303 T/G cg16660971 chr17:78860029 RPTOR 0.37 5.97 0.31 5.95e-9 Major depressive disorder; LUSC cis rs34779708 0.966 rs4934537 chr10:35441512 C/T cg03585969 chr10:35415529 CREM 0.6 8.77 0.43 9.27e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17401966 1.000 rs1049887 chr1:10460485 T/C cg19773385 chr1:10388646 KIF1B -0.53 -7.97 -0.4 2.49e-14 Hepatocellular carcinoma; LUSC cis rs6545883 0.895 rs4430924 chr2:61703856 A/G cg15711740 chr2:61764176 XPO1 -0.42 -6.26 -0.32 1.17e-9 Tuberculosis; LUSC cis rs9462027 0.583 rs7755982 chr6:34715297 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.9 -0.31 9.02e-9 Systemic lupus erythematosus; LUSC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9788721 0.836 rs17405217 chr15:78731149 C/T cg18825076 chr15:78729989 IREB2 -0.63 -10.25 -0.49 1.32e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs921968 0.541 rs12617603 chr2:219369288 A/G cg02176678 chr2:219576539 TTLL4 -0.74 -14.23 -0.61 3.13e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg11752832 chr7:134001865 SLC35B4 0.56 8.67 0.43 1.86e-16 Mean platelet volume; LUSC cis rs6840360 0.615 rs4696267 chr4:152464500 A/G cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.602 rs1716160 chr12:123700225 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs6424115 0.679 rs2267961 chr1:24071048 A/G cg15997130 chr1:24165203 NA -0.48 -6.75 -0.35 6.61e-11 Immature fraction of reticulocytes; LUSC cis rs6541297 1.000 rs6682741 chr1:230279090 T/C cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.39e-15 Coronary artery disease; LUSC cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.57 -0.46 2.4e-19 Systolic blood pressure; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.31 -0.41 2.51e-15 Obesity-related traits; LUSC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg04455712 chr21:45112962 RRP1B 0.43 8.05 0.4 1.47e-14 Mean corpuscular volume; LUSC cis rs1443512 0.704 rs4759308 chr12:54329031 A/T cg25024717 chr12:54324583 NA -0.39 -6.74 -0.35 6.86e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs2637266 0.967 rs2579760 chr10:78321768 A/C cg18941641 chr10:78392320 NA 0.37 6.75 0.35 6.47e-11 Pulmonary function; LUSC cis rs7614311 0.636 rs3821902 chr3:63941697 T/G cg22134162 chr3:63841271 THOC7 -0.47 -5.96 -0.31 6.34e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs10911251 0.546 rs1547714 chr1:183114119 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC trans rs6561151 0.681 rs17653353 chr13:44421746 A/G cg12856521 chr11:46389249 DGKZ 0.79 9.62 0.47 1.67e-19 Crohn's disease; LUSC cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg08213375 chr14:104286397 PPP1R13B 0.52 10.23 0.49 1.55e-21 Schizophrenia; LUSC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.71 0.78 1.1e-69 Height; LUSC cis rs77633900 0.685 rs2469556 chr15:76650148 G/A cg21673338 chr15:77095150 SCAPER -0.72 -6.22 -0.32 1.5e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs709400 0.628 rs11622320 chr14:103912194 A/T cg12935359 chr14:103987150 CKB -0.56 -8.48 -0.42 7.62e-16 Body mass index; LUSC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.19 15.48 0.65 4.17e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2346177 0.811 rs4953373 chr2:46652145 G/C cg02822958 chr2:46747628 ATP6V1E2 0.35 5.95 0.31 6.82e-9 HDL cholesterol; LUSC cis rs11229555 0.874 rs11601687 chr11:58338628 T/C cg15696309 chr11:58395628 NA -0.7 -9.06 -0.44 1.12e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg15448220 chr1:150897856 SETDB1 0.43 6.24 0.32 1.35e-9 Melanoma; LUSC cis rs2387326 0.717 rs10829342 chr10:129944493 C/T cg16087940 chr10:129947807 NA -0.39 -6.0 -0.31 5e-9 Select biomarker traits; LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs9309473 0.519 rs2421574 chr2:73908767 C/G cg20560298 chr2:73613845 ALMS1 0.41 6.18 0.32 1.83e-9 Metabolite levels; LUSC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.21e-12 Schizophrenia; LUSC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg20891558 chr2:74357851 NA 0.79 13.2 0.59 2.61e-32 Gestational age at birth (maternal effect); LUSC cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg05347473 chr6:146136440 FBXO30 0.53 9.06 0.44 1.13e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg22903657 chr4:1355424 KIAA1530 -0.35 -6.0 -0.31 5.02e-9 Obesity-related traits; LUSC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg03354898 chr7:1950403 MAD1L1 -0.37 -7.0 -0.36 1.43e-11 Schizophrenia; LUSC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg13390004 chr1:15929781 NA 0.42 6.86 0.35 3.25e-11 Systolic blood pressure; LUSC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg06634786 chr22:41940651 POLR3H 0.51 6.11 0.32 2.82e-9 Vitiligo; LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg08859206 chr1:53392774 SCP2 0.77 14.68 0.63 5.42e-38 Monocyte count; LUSC cis rs3770081 1.000 rs3731819 chr2:86368641 C/A cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.86 -0.35 3.43e-11 Facial emotion recognition (sad faces); LUSC cis rs6987853 0.787 rs12677427 chr8:42414226 T/A cg09913449 chr8:42400586 C8orf40 0.53 9.22 0.45 3.48e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs9522267 0.535 rs914036 chr13:112235542 G/A cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 2.99e-8 Hepatitis; LUSC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg22862634 chr11:62369728 EML3;MTA2 0.51 7.43 0.38 9.21e-13 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs1904096 0.506 rs7439869 chr4:95173779 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.31 -0.41 2.41e-15 Type 2 diabetes; LUSC cis rs478304 0.651 rs10896038 chr11:65505528 G/C cg27068330 chr11:65405492 SIPA1 -0.76 -10.98 -0.51 3.78e-24 Acne (severe); LUSC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg23422044 chr7:1970798 MAD1L1 -0.57 -6.3 -0.33 9.35e-10 Bipolar disorder; LUSC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg21699342 chr2:239360505 ASB1 0.57 10.59 0.5 8.38e-23 Multiple system atrophy; LUSC cis rs1577917 0.837 rs806529 chr6:86467121 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.48 -0.33 3.39e-10 Response to antipsychotic treatment; LUSC cis rs12681287 0.640 rs13253515 chr8:87458596 T/A cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs7463659 0.904 rs7826572 chr8:135433805 G/T cg17885191 chr8:135476712 NA -0.4 -5.67 -0.3 3.15e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs4417855 0.665 rs7653032 chr3:187413388 G/A cg19198148 chr3:187451818 BCL6 0.56 9.78 0.47 4.99e-20 Granulocyte percentage of myeloid white cells; LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.62 0.47 1.65e-19 Bipolar disorder; LUSC cis rs9300255 0.602 rs1727317 chr12:123618942 T/C cg00376283 chr12:123451042 ABCB9 0.68 7.67 0.39 1.89e-13 Neutrophil percentage of white cells; LUSC cis rs7715806 0.500 rs17649332 chr5:75003878 T/C cg19683494 chr5:74908142 NA 0.58 7.75 0.39 1.15e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.46e-23 Gut microbiome composition (summer); LUSC cis rs4919694 1.000 rs77318450 chr10:104733098 A/G cg04362960 chr10:104952993 NT5C2 1.15 13.45 0.59 2.87e-33 Arsenic metabolism; LUSC cis rs2439831 0.867 rs2412779 chr15:43655927 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.88 9.44 0.46 6.76e-19 Lung cancer in ever smokers; LUSC cis rs9916302 0.706 rs584377 chr17:37460128 G/A cg07936489 chr17:37558343 FBXL20 0.77 9.55 0.46 2.96e-19 Glomerular filtration rate (creatinine); LUSC cis rs10782582 0.609 rs1251584 chr1:76424440 C/T cg10523679 chr1:76189770 ACADM 0.4 5.69 0.3 2.84e-8 Daytime sleep phenotypes; LUSC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg17252645 chr8:143867129 LY6D 0.37 6.61 0.34 1.55e-10 Urinary tract infection frequency; LUSC cis rs9462027 0.628 rs6924898 chr6:34811199 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.82 -0.3 1.35e-8 Systemic lupus erythematosus; LUSC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg17971929 chr21:40555470 PSMG1 0.54 8.48 0.42 7.21e-16 Cognitive function; LUSC cis rs6733011 0.518 rs12712033 chr2:99457973 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.78 -0.35 5.61e-11 Bipolar disorder; LUSC cis rs13315871 0.929 rs13097873 chr3:58267924 C/T cg12435725 chr3:58293450 RPP14 -0.78 -7.71 -0.39 1.45e-13 Cholesterol, total; LUSC cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg06784218 chr1:46089804 CCDC17 0.47 9.31 0.45 1.81e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg15534020 chr5:154320467 MRPL22 0.37 6.06 0.31 3.67e-9 Schizophrenia; LUSC cis rs921665 0.748 rs11677991 chr2:3185321 G/A cg16434511 chr2:3151078 NA -0.53 -6.35 -0.33 7.11e-10 World class endurance athleticism; LUSC trans rs7829975 0.593 rs2921051 chr8:8320104 C/A cg21775007 chr8:11205619 TDH 0.44 6.6 0.34 1.61e-10 Mood instability; LUSC cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9831754 1.000 rs9855903 chr3:78347988 C/A cg06138941 chr3:78371609 NA -0.75 -10.03 -0.48 7.14e-21 Calcium levels; LUSC cis rs11577318 1.000 rs11577318 chr1:26601570 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -5.82 -0.3 1.37e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs9788682 0.747 rs2656073 chr15:78742276 G/T cg06917634 chr15:78832804 PSMA4 -0.48 -6.02 -0.31 4.65e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs734999 0.588 rs4648562 chr1:2535613 C/A cg18854424 chr1:2615690 NA 0.5 9.97 0.48 1.12e-20 Ulcerative colitis; LUSC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg21918786 chr6:109611834 NA -0.41 -7.01 -0.36 1.35e-11 Reticulocyte fraction of red cells; LUSC cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg08807101 chr21:30365312 RNF160 -0.53 -7.9 -0.4 4.17e-14 Dental caries; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18075040 chr12:96337100 AMDHD1;CCDC38 -0.55 -6.73 -0.35 7.56e-11 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -7.0 -0.36 1.41e-11 Bipolar disorder; LUSC cis rs1728785 1.000 rs8058145 chr16:68584090 G/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs7843479 0.544 rs7839925 chr8:21792983 G/C cg16476235 chr8:21771668 DOK2 0.24 5.68 0.3 2.89e-8 Mean corpuscular volume; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.49 0.46 4.39e-19 Intelligence (multi-trait analysis); LUSC cis rs1113500 0.614 rs11185243 chr1:108597141 T/C cg11967332 chr1:108735228 SLC25A24 0.42 5.82 0.3 1.35e-8 Growth-regulated protein alpha levels; LUSC cis rs738322 0.967 rs6001038 chr22:38570585 A/G cg25457927 chr22:38595422 NA -0.42 -8.92 -0.44 3.05e-17 Cutaneous nevi; LUSC cis rs11676348 0.774 rs11683524 chr2:218984604 G/A cg00012203 chr2:219082015 ARPC2 -0.53 -8.08 -0.4 1.19e-14 Ulcerative colitis; LUSC cis rs7264396 0.635 rs6060681 chr20:34506147 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.94 -0.44 2.7e-17 Total cholesterol levels; LUSC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg12311346 chr5:56204834 C5orf35 -0.55 -8.32 -0.41 2.23e-15 Coronary artery disease; LUSC trans rs61931739 0.500 rs7306053 chr12:34510848 T/G cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.19e-33 Morning vs. evening chronotype; LUSC cis rs2717559 0.542 rs11777634 chr8:143887957 C/T cg07661805 chr8:143867942 LY6D -0.25 -5.82 -0.3 1.37e-8 Urinary tract infection frequency; LUSC cis rs11190604 1.000 rs4919468 chr10:102288343 G/C cg07080220 chr10:102295463 HIF1AN 0.68 8.74 0.43 1.19e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg11062466 chr8:58055876 NA 0.58 7.3 0.37 2.12e-12 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.86 10.92 0.51 5.95e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2124969 0.548 rs983916 chr2:161015066 T/G cg03641300 chr2:160917029 PLA2R1 -0.47 -5.7 -0.3 2.7e-8 Waist circumference adjusted for body mass index; LUSC cis rs9463078 0.817 rs9369523 chr6:44908728 T/C cg25276700 chr6:44698697 NA -0.31 -6.1 -0.32 2.86e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9583531 0.689 rs9521913 chr13:111382058 C/T cg24331049 chr13:111365604 ING1 -0.52 -6.84 -0.35 3.86e-11 Coronary artery disease; LUSC cis rs6998277 0.830 rs12543046 chr8:103603809 A/G cg10187029 chr8:103597600 NA -0.79 -12.46 -0.56 1.64e-29 Migraine; LUSC cis rs2011503 0.941 rs55822665 chr19:19383298 C/T cg11244672 chr19:19639970 YJEFN3 -0.55 -6.91 -0.35 2.49e-11 Bipolar disorder; LUSC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg22029157 chr1:209979665 IRF6 0.78 9.2 0.45 4.04e-18 Cleft lip with or without cleft palate; LUSC cis rs968451 1.000 rs17000962 chr22:39680187 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.7 8.9 0.44 3.7e-17 Primary biliary cholangitis; LUSC trans rs9467711 0.790 rs45527431 chr6:26599509 A/G cg06606381 chr12:133084897 FBRSL1 -0.9 -7.6 -0.38 3.06e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg14004847 chr7:1930337 MAD1L1 -0.52 -8.08 -0.4 1.19e-14 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.36 -0.69 1.44e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg15534755 chr11:117069859 TAGLN 0.34 5.91 0.31 8.33e-9 Blood protein levels; LUSC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg25258033 chr6:167368657 RNASET2 -0.46 -7.78 -0.39 9e-14 Crohn's disease; LUSC cis rs3931020 0.688 rs455032 chr1:75196488 C/T cg00121533 chr1:75199117 CRYZ;TYW3 -0.46 -5.92 -0.31 8.17e-9 Resistin levels; LUSC cis rs865483 0.895 rs853208 chr17:35826456 C/A cg06716730 chr17:35851459 DUSP14 0.28 6.18 0.32 1.91e-9 Monocyte count; LUSC cis rs11190604 1.000 rs12219158 chr10:102302923 T/C cg23241863 chr10:102295624 HIF1AN 0.48 5.72 0.3 2.38e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg08847533 chr14:75593920 NEK9 -0.85 -15.75 -0.65 3.57e-42 Height; LUSC cis rs7923609 0.783 rs7907451 chr10:65328740 T/A cg01631684 chr10:65280961 REEP3 0.4 5.97 0.31 6.17e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg12011299 chr4:100065546 ADH4 -0.7 -10.85 -0.51 1.05e-23 Alcohol dependence; LUSC cis rs7829975 0.686 rs907180 chr8:8702827 A/G cg06636001 chr8:8085503 FLJ10661 0.58 9.18 0.45 4.63e-18 Mood instability; LUSC cis rs6964587 0.869 rs10278155 chr7:91532456 T/G cg22709100 chr7:91322751 NA -0.39 -5.68 -0.3 2.94e-8 Breast cancer; LUSC cis rs8060686 0.858 rs7198357 chr16:67884619 A/G cg26727032 chr16:67993705 SLC12A4 0.38 5.76 0.3 1.89e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg12310025 chr6:25882481 NA -0.41 -7.28 -0.37 2.45e-12 Height; LUSC cis rs41271473 0.526 rs10916339 chr1:228716894 C/T cg10167378 chr1:228756711 NA 0.74 9.51 0.46 3.81e-19 Chronic lymphocytic leukemia; LUSC cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg04362960 chr10:104952993 NT5C2 0.58 8.5 0.42 6.52e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg01483505 chr11:975446 AP2A2 0.4 5.76 0.3 1.92e-8 Alzheimer's disease (late onset); LUSC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.65 -0.34 1.17e-10 Menarche (age at onset); LUSC cis rs9341808 0.718 rs9448886 chr6:80825901 C/T cg08355045 chr6:80787529 NA 0.56 9.85 0.47 2.85e-20 Sitting height ratio; LUSC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg17143192 chr8:8559678 CLDN23 0.64 9.1 0.45 8.37e-18 Obesity-related traits; LUSC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg08677398 chr8:58056175 NA 0.52 6.01 0.31 4.77e-9 Developmental language disorder (linguistic errors); LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.72 -0.43 1.38e-16 Bipolar disorder; LUSC cis rs921968 0.612 rs496908 chr2:219357742 A/T cg02176678 chr2:219576539 TTLL4 0.65 11.5 0.53 5.29e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs56163509 1 rs56163509 chr16:28864471 A/G cg05966235 chr16:28915196 ATP2A1 0.34 5.96 0.31 6.43e-9 Tonsillectomy;Mean corpuscular volume; LUSC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs8141529 0.719 rs132561 chr22:29351179 C/T cg02153584 chr22:29168773 CCDC117 -0.52 -7.85 -0.39 5.88e-14 Lymphocyte counts; LUSC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.64 0.57 3.49e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg22823121 chr1:150693482 HORMAD1 0.47 6.9 0.35 2.62e-11 Melanoma; LUSC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.33 -0.33 8.09e-10 Extrinsic epigenetic age acceleration; LUSC cis rs669446 0.533 rs6429638 chr1:44211010 A/G cg15962314 chr1:44399869 ARTN 0.24 5.65 0.3 3.46e-8 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.517 rs1817760 chr12:34106060 A/G cg26384229 chr12:38710491 ALG10B 0.71 11.18 0.52 7.25e-25 Morning vs. evening chronotype; LUSC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 6.16 0.32 2.14e-9 Tonsillectomy; LUSC cis rs6733011 0.600 rs1356424 chr2:99425838 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.98 -0.36 1.57e-11 Bipolar disorder; LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg24829409 chr8:58192753 C8orf71 -0.5 -6.1 -0.32 2.86e-9 Developmental language disorder (linguistic errors); LUSC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg13722127 chr7:150037890 RARRES2 0.4 5.92 0.31 7.83e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs6601327 0.736 rs4840426 chr8:9408978 G/T cg15556689 chr8:8085844 FLJ10661 0.43 6.06 0.31 3.76e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs6596100 0.538 rs66481372 chr5:132179592 T/A cg02081065 chr5:132209139 LEAP2 -0.62 -6.02 -0.31 4.62e-9 Breast cancer; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs1971762 0.583 rs7979659 chr12:54086579 A/G cg23533419 chr12:54090519 NA -0.37 -6.04 -0.31 4.12e-9 Height; LUSC cis rs9807841 0.592 rs10401513 chr19:10778763 A/T cg17710535 chr19:10819994 QTRT1 0.42 6.87 0.35 3.21e-11 Inflammatory skin disease; LUSC cis rs10751667 0.560 rs7924794 chr11:962745 A/T ch.11.42038R chr11:967971 AP2A2 0.44 6.62 0.34 1.45e-10 Alzheimer's disease (late onset); LUSC cis rs79349575 0.783 rs12601955 chr17:47034420 C/T cg22482690 chr17:47019901 SNF8 0.38 7.01 0.36 1.35e-11 Type 2 diabetes; LUSC cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg07157834 chr1:205819609 PM20D1 0.98 21.34 0.76 2.33e-64 Menarche (age at onset); LUSC cis rs7917772 0.582 rs4285804 chr10:104386309 T/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.75 -0.51 2.34e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs3820928 0.874 rs6718057 chr2:227834349 T/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.42 -0.38 9.97e-13 Pulmonary function; LUSC trans rs8072100 0.581 rs4267364 chr17:45781264 A/G cg04995722 chr7:26192034 NFE2L3 -0.43 -6.64 -0.34 1.24e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16266895 chr12:101674004 UTP20 0.42 6.11 0.32 2.83e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg02038168 chr22:39784481 NA -0.47 -7.27 -0.37 2.54e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs3768617 0.510 rs10752900 chr1:183086238 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs8018808 0.935 rs4903584 chr14:77934758 A/G cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs950169 0.881 rs150965 chr15:85080527 T/G cg17173187 chr15:85201210 NMB 0.39 6.79 0.35 5.22e-11 Schizophrenia; LUSC cis rs2439831 0.867 rs8039638 chr15:43634405 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.16 0.58 3.88e-32 Lung cancer in ever smokers; LUSC trans rs9951602 0.512 rs9958497 chr18:76655296 G/C cg02800362 chr5:177631904 HNRNPAB 0.87 12.81 0.57 8.07e-31 Obesity-related traits; LUSC cis rs2559856 1.000 rs10745921 chr12:102087193 A/G cg12924262 chr12:102091054 CHPT1 0.43 6.04 0.31 4e-9 Blood protein levels; LUSC cis rs2730245 0.527 rs62475645 chr7:158656825 G/A cg11984989 chr7:158649758 WDR60 1.14 13.69 0.6 3.45e-34 Height; LUSC cis rs1832871 1.000 rs1832871 chr6:158722034 C/T cg07165851 chr6:158734300 TULP4 0.36 6.29 0.33 9.99e-10 Height; LUSC cis rs7615316 0.844 rs13075471 chr3:142191659 T/C cg16271453 chr3:142027066 XRN1 -0.38 -6.53 -0.34 2.42e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2806561 0.704 rs664301 chr1:23522522 C/T cg19743168 chr1:23544995 NA 0.46 9.11 0.45 8.03e-18 Height; LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC cis rs7615952 0.515 rs7630575 chr3:125682330 A/G cg15145296 chr3:125709740 NA -0.5 -5.75 -0.3 2e-8 Blood pressure (smoking interaction); LUSC cis rs7582180 0.764 rs920269 chr2:100918363 G/A cg12002119 chr2:101014098 CHST10 0.34 5.74 0.3 2.09e-8 Intelligence (multi-trait analysis); LUSC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg03709012 chr19:19516395 GATAD2A 0.85 13.95 0.61 3.77e-35 Tonsillectomy; LUSC cis rs6582630 0.576 rs4882258 chr12:38453686 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.19 -0.41 5.68e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs7084921 0.608 rs11597561 chr10:101863041 T/C cg02250046 chr10:101825185 CPN1 -0.35 -6.33 -0.33 7.9e-10 Bone mineral density; LUSC cis rs362272 0.524 rs6819202 chr4:3368264 G/A cg18352616 chr4:3374830 RGS12 0.3 5.95 0.31 6.73e-9 Serum sulfate level; LUSC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC cis rs6138458 1.000 rs6707 chr20:24944166 C/T cg26195577 chr20:24973756 C20orf3 1.11 18.17 0.71 8.49e-52 Blood protein levels; LUSC cis rs713587 0.563 rs10865315 chr2:25100738 C/A cg15423357 chr2:25149977 NA 0.37 7.19 0.37 4.31e-12 Body mass index in non-asthmatics; LUSC trans rs335206 0.542 rs55981521 chr5:122477177 C/T cg01368872 chr15:91498139 RCCD1 -0.45 -6.07 -0.32 3.42e-9 QRS duration; LUSC cis rs859767 0.709 rs7575742 chr2:135429002 A/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.11 -0.32 2.76e-9 Neuroticism; LUSC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6733011 0.531 rs13004923 chr2:99497561 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.83 -0.3 1.3e-8 Bipolar disorder; LUSC cis rs13082711 0.911 rs7644466 chr3:27515271 C/G cg02860705 chr3:27208620 NA 0.46 7.61 0.38 2.79e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs1577917 0.727 rs9444361 chr6:86400900 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.69 10.93 0.51 5.6e-24 Response to antipsychotic treatment; LUSC cis rs57590327 0.503 rs2049415 chr3:81901887 A/T cg07356753 chr3:81810745 GBE1 -0.66 -10.49 -0.5 2e-22 Extraversion; LUSC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg20573242 chr4:122745356 CCNA2 0.43 6.6 0.34 1.62e-10 Type 2 diabetes; LUSC cis rs6840360 0.642 rs2709842 chr4:152370637 C/T cg20465933 chr4:152376761 FAM160A1 -0.32 -5.74 -0.3 2.1e-8 Intelligence (multi-trait analysis); LUSC cis rs10186029 0.509 rs13425936 chr2:213940346 C/T cg08319019 chr2:214017104 IKZF2 -0.42 -6.12 -0.32 2.64e-9 Systemic sclerosis; LUSC cis rs2932538 0.885 rs6661642 chr1:113090109 T/C cg22162597 chr1:113214053 CAPZA1 0.7 10.11 0.48 3.74e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs1459104 0.866 rs12804916 chr11:54831763 G/A cg03929089 chr4:120376271 NA 0.74 6.38 0.33 5.96e-10 Body mass index; LUSC cis rs17401966 1.000 rs7530167 chr1:10453374 A/G cg19773385 chr1:10388646 KIF1B -0.53 -8.19 -0.41 5.74e-15 Hepatocellular carcinoma; LUSC trans rs6582630 0.519 rs11495373 chr12:38275470 T/C cg06521331 chr12:34319734 NA -0.4 -6.08 -0.32 3.28e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs59698941 0.943 rs67162224 chr5:132289372 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs9309473 0.687 rs12465867 chr2:73612102 C/T cg20560298 chr2:73613845 ALMS1 -0.59 -8.68 -0.43 1.78e-16 Metabolite levels; LUSC cis rs950169 0.650 rs12902052 chr15:85125838 A/T cg12863693 chr15:85201151 NMB 0.37 7.52 0.38 4.96e-13 Schizophrenia; LUSC trans rs6951245 1.000 rs79617366 chr7:1111958 G/C cg13565492 chr6:43139072 SRF -0.63 -6.63 -0.34 1.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg25072359 chr17:41440525 NA 0.62 9.05 0.44 1.2e-17 Menopause (age at onset); LUSC cis rs12410462 0.681 rs12401677 chr1:227608577 T/C cg04117972 chr1:227635322 NA 0.73 7.6 0.38 2.92e-13 Major depressive disorder; LUSC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg15664640 chr17:80829946 TBCD -0.73 -12.62 -0.57 4.09e-30 Breast cancer; LUSC cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg23711669 chr6:146136114 FBXO30 -0.89 -16.79 -0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9788682 0.747 rs2656071 chr15:78745343 A/T cg06917634 chr15:78832804 PSMA4 0.49 6.18 0.32 1.86e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.12 0.52 1.19e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg17279839 chr7:150038598 RARRES2 0.51 7.37 0.37 1.33e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg12463550 chr7:65579703 CRCP 0.42 6.03 0.31 4.28e-9 Aortic root size; LUSC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg00033643 chr7:134001901 SLC35B4 0.47 7.35 0.37 1.53e-12 Mean platelet volume; LUSC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg07701084 chr6:150067640 NUP43 0.52 7.4 0.38 1.12e-12 Lung cancer; LUSC cis rs16854884 0.657 rs34683397 chr3:143723559 C/T cg06585982 chr3:143692056 C3orf58 0.46 7.12 0.36 6.6e-12 Economic and political preferences (feminism/equality); LUSC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg03060546 chr3:49711283 APEH -0.68 -9.99 -0.48 1.02e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9535307 1.000 rs9535307 chr13:50291842 A/C cg04663916 chr13:50265991 EBPL 0.49 5.71 0.3 2.44e-8 Obesity-related traits; LUSC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg22903471 chr2:27725779 GCKR -0.4 -6.94 -0.36 1.99e-11 Total body bone mineral density; LUSC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg23711669 chr6:146136114 FBXO30 0.83 14.82 0.63 1.57e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs459571 0.920 rs2520094 chr9:136919985 A/T cg01294253 chr9:136912663 BRD3 0.33 5.74 0.3 2.08e-8 Platelet distribution width; LUSC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg12463550 chr7:65579703 CRCP 0.52 7.64 0.39 2.32e-13 Aortic root size; LUSC cis rs992157 0.764 rs4672886 chr2:219185545 C/T cg00012203 chr2:219082015 ARPC2 -0.55 -8.23 -0.41 4.19e-15 Colorectal cancer; LUSC cis rs826838 0.559 rs1843891 chr12:38617018 T/C cg13010199 chr12:38710504 ALG10B 0.48 7.28 0.37 2.47e-12 Heart rate; LUSC cis rs7100689 0.725 rs10749574 chr10:82136856 T/C cg00277334 chr10:82204260 NA -0.48 -6.6 -0.34 1.65e-10 Post bronchodilator FEV1; LUSC cis rs11105298 0.891 rs10858872 chr12:89872932 C/T cg00757033 chr12:89920650 WDR51B 0.6 10.33 0.49 7.01e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg05340658 chr4:99064831 C4orf37 0.63 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12893668 0.543 rs12147645 chr14:104100208 T/A cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.42 -0.38 9.83e-13 Reticulocyte count; LUSC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg19729930 chr2:74357872 NA 0.88 15.31 0.64 1.86e-40 Gestational age at birth (maternal effect); LUSC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg24531977 chr5:56204891 C5orf35 -0.59 -8.63 -0.43 2.49e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.51 0.65 3.02e-41 Platelet count; LUSC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.11e-11 Crohn's disease; LUSC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg12403142 chr1:92012408 NA 0.4 6.33 0.33 8.11e-10 Breast cancer; LUSC trans rs208520 0.690 rs207082 chr6:66773796 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -16.65 -0.67 9.68e-46 Exhaled nitric oxide output; LUSC cis rs68170813 0.559 rs77605964 chr7:106962948 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.46 -0.46 5.6e-19 Coronary artery disease; LUSC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg18131467 chr2:239335373 ASB1 1.05 24.64 0.8 4.06e-77 Multiple system atrophy; LUSC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg06637938 chr14:75390232 RPS6KL1 0.52 8.29 0.41 2.85e-15 Height; LUSC cis rs7843479 0.601 rs11780532 chr8:21838670 T/A cg17168535 chr8:21777572 XPO7 0.82 15.11 0.64 1.14e-39 Mean corpuscular volume; LUSC cis rs9467773 0.620 rs2498351 chr6:26659642 C/T cg11502198 chr6:26597334 ABT1 0.73 12.25 0.56 9.63e-29 Intelligence (multi-trait analysis); LUSC cis rs1348850 0.750 rs12997716 chr2:178494629 G/A cg22681709 chr2:178499509 PDE11A -0.55 -10.45 -0.5 2.67e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3820068 0.608 rs7516683 chr1:16020502 A/G cg24675056 chr1:15929824 NA -0.39 -6.42 -0.33 4.75e-10 Systolic blood pressure; LUSC trans rs11098499 0.909 rs2127821 chr4:120394535 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.33 0.33 7.94e-10 Corneal astigmatism; LUSC cis rs6546550 0.867 rs7592647 chr2:70139134 C/T cg02498382 chr2:70120550 SNRNP27 -0.28 -6.83 -0.35 4.13e-11 Prevalent atrial fibrillation; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13114696 chr21:47808953 PCNT 0.51 6.62 0.34 1.47e-10 Bipolar disorder and schizophrenia; LUSC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg26727032 chr16:67993705 SLC12A4 -0.44 -5.93 -0.31 7.53e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.2e-9 Menopause (age at onset); LUSC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg06618935 chr21:46677482 NA -0.37 -7.33 -0.37 1.75e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9291683 0.552 rs10939656 chr4:10014646 A/C cg11266682 chr4:10021025 SLC2A9 0.56 10.33 0.49 6.79e-22 Bone mineral density; LUSC cis rs3820928 0.874 rs13385711 chr2:227830414 G/T cg11843606 chr2:227700838 RHBDD1 -0.52 -7.42 -0.38 9.97e-13 Pulmonary function; LUSC cis rs2274273 0.805 rs8012156 chr14:55552500 G/T cg04306507 chr14:55594613 LGALS3 0.51 11.07 0.52 1.75e-24 Protein biomarker; LUSC cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 9.42 0.46 7.68e-19 IgG glycosylation; LUSC cis rs7474896 1.000 rs734512 chr10:37973072 C/T cg25427524 chr10:38739819 LOC399744 0.52 5.86 0.31 1.1e-8 Obesity (extreme); LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.0 -0.58 1.54e-31 Platelet count; LUSC cis rs10186029 0.676 rs10497991 chr2:213968775 G/A cg08319019 chr2:214017104 IKZF2 0.6 8.76 0.43 9.95e-17 Systemic sclerosis; LUSC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.48 8.59 0.43 3.41e-16 Total body bone mineral density; LUSC cis rs6845621 1.000 rs6845621 chr4:18866169 G/A cg12196642 chr4:18937545 NA -0.32 -6.09 -0.32 3.18e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg07424592 chr7:64974309 NA 0.68 6.01 0.31 4.75e-9 Diabetic kidney disease; LUSC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg04369109 chr6:150039330 LATS1 -0.56 -7.79 -0.39 8.3e-14 Lung cancer; LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg26314531 chr2:26401878 FAM59B -0.67 -8.92 -0.44 3.07e-17 Gut microbiome composition (summer); LUSC trans rs11264799 0.765 rs12125713 chr1:157636657 A/G cg25498969 chr3:136062740 STAG1 -0.24 -5.95 -0.31 6.9e-9 IgA nephropathy; LUSC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg03605463 chr16:89740564 NA -0.39 -5.78 -0.3 1.68e-8 Vitiligo; LUSC cis rs4516970 0.826 rs59246098 chr6:160149462 C/CA cg06131755 chr6:160182447 ACAT2 0.6 8.27 0.41 3.27e-15 Iron status biomarkers; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg07157834 chr1:205819609 PM20D1 0.85 15.25 0.64 3.19e-40 Menarche (age at onset); LUSC cis rs9467773 0.583 rs2498380 chr6:26643996 C/G cg11502198 chr6:26597334 ABT1 -0.69 -11.7 -0.54 9.85e-27 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.582 rs10786691 chr10:104364652 G/A cg05855489 chr10:104503620 C10orf26 -0.49 -7.42 -0.38 9.5e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17407555 0.821 rs4292329 chr4:10144459 C/G cg00071950 chr4:10020882 SLC2A9 -0.47 -5.66 -0.3 3.18e-8 Schizophrenia (age at onset); LUSC cis rs9837602 1.000 rs9833980 chr3:99767096 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.15 0.32 2.19e-9 Breast cancer; LUSC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg14552801 chr7:65878734 NA -0.44 -6.11 -0.32 2.79e-9 Aortic root size; LUSC trans rs1814175 0.684 rs1827015 chr11:49585241 A/G cg15704280 chr7:45808275 SEPT13 -0.98 -16.61 -0.67 1.43e-45 Height; LUSC cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.69 0.65 5.76e-42 Bladder cancer; LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg11843238 chr5:131593191 PDLIM4 -0.5 -8.56 -0.42 4.14e-16 Acylcarnitine levels; LUSC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg09165964 chr15:75287851 SCAMP5 0.52 7.59 0.38 3.32e-13 Breast cancer; LUSC cis rs7923609 0.967 rs10509189 chr10:65264126 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.07e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg20887711 chr4:1340912 KIAA1530 0.72 11.83 0.54 3.35e-27 Longevity; LUSC cis rs34421088 0.506 rs7813424 chr8:11144517 G/A cg21775007 chr8:11205619 TDH 0.5 7.07 0.36 9.06e-12 Neuroticism; LUSC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs72772090 0.539 rs67140788 chr5:96116286 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.78 -0.35 5.49e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg05064044 chr6:292385 DUSP22 -0.52 -7.75 -0.39 1.09e-13 Menopause (age at onset); LUSC cis rs16976116 0.901 rs56328329 chr15:55502977 A/T cg11288833 chr15:55489084 RSL24D1 0.51 6.16 0.32 2.05e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7129556 0.520 rs10793257 chr11:77309533 T/C cg12586386 chr11:77299805 AQP11 0.22 5.64 0.3 3.56e-8 Weight loss (gastric bypass surgery); LUSC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg11663144 chr21:46675770 NA -0.41 -7.14 -0.36 5.99e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 13.25 0.59 1.72e-32 Alzheimer's disease; LUSC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg17221980 chr6:117996486 NUS1 0.36 6.11 0.32 2.82e-9 Triglycerides; LUSC cis rs202011557 1 rs202011557 chr2:102913642 A/AAAAC cg20060108 chr2:102954350 IL1RL1 0.48 5.68 0.3 2.96e-8 Asthma; LUSC cis rs710865 0.723 rs710870 chr1:19549759 G/A cg13387374 chr1:19411106 UBR4 0.5 7.66 0.39 2.07e-13 Brain structure; LUSC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg06850241 chr22:41845214 NA 0.31 5.73 0.3 2.23e-8 Vitiligo; LUSC cis rs2439831 0.867 rs8039638 chr15:43634405 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 4.03e-19 Lung cancer in ever smokers; LUSC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg09650180 chr20:62225654 GMEB2 -0.68 -9.76 -0.47 5.63e-20 Glioblastoma; LUSC cis rs3740713 1.000 rs73440625 chr11:18470800 A/G cg15463284 chr11:18477534 LDHAL6A -0.5 -5.73 -0.3 2.21e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg11218175 chr11:495084 RNH1 0.53 5.69 0.3 2.77e-8 Body mass index; LUSC cis rs2050392 1.000 rs2265185 chr10:30691777 A/C cg18806716 chr10:30721971 MAP3K8 -0.47 -7.59 -0.38 3.25e-13 Inflammatory bowel disease; LUSC cis rs1808579 0.935 rs4800162 chr18:21117419 G/T cg14672496 chr18:21087552 C18orf8 0.36 6.23 0.32 1.37e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs13315871 0.929 rs77487951 chr3:58290892 G/A cg20936604 chr3:58311152 NA -0.71 -6.33 -0.33 7.74e-10 Cholesterol, total; LUSC cis rs4148883 0.651 rs10020052 chr4:100086331 C/G cg12011299 chr4:100065546 ADH4 0.47 7.67 0.39 1.9e-13 Alcohol dependence; LUSC trans rs61931739 0.963 rs12298565 chr12:34036188 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs7122539 0.646 rs627330 chr11:66602099 C/T cg24851651 chr11:66362959 CCS 0.55 9.69 0.47 9.57e-20 HIV-1 susceptibility; LUSC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg07777115 chr5:623756 CEP72 -0.45 -5.74 -0.3 2.16e-8 Obesity-related traits; LUSC trans rs2832191 0.692 rs2245517 chr21:30357968 C/T cg14791747 chr16:20752902 THUMPD1 -0.42 -6.42 -0.33 4.65e-10 Dental caries; LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg18758796 chr5:131593413 PDLIM4 0.47 7.82 0.39 7.05e-14 Acylcarnitine levels; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg16145915 chr7:1198662 ZFAND2A -0.61 -11.32 -0.53 2.37e-25 Longevity;Endometriosis; LUSC cis rs11626933 0.885 rs28517514 chr14:90788709 G/A cg14092571 chr14:90743983 NA -0.82 -16.53 -0.67 2.75e-45 Gut microbiota (bacterial taxa); LUSC cis rs2414856 0.510 rs72756978 chr15:64572492 T/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs9463078 0.605 rs9472416 chr6:44950963 T/C cg25276700 chr6:44698697 NA 0.29 6.05 0.31 3.94e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg11812906 chr14:75593930 NEK9 0.62 10.17 0.49 2.36e-21 Height; LUSC cis rs7584330 0.554 rs3751107 chr2:238427251 G/A cg16989719 chr2:238392110 NA -0.43 -6.24 -0.32 1.34e-9 Prostate cancer; LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg11645453 chr3:52864694 ITIH4 0.26 5.95 0.31 6.74e-9 Bipolar disorder; LUSC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 9.64 0.47 1.43e-19 Eosinophil percentage of white cells; LUSC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg09509183 chr1:209979624 IRF6 0.43 5.84 0.3 1.26e-8 Cleft lip with or without cleft palate; LUSC cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg12219531 chr12:120966889 COQ5 0.61 8.09 0.4 1.1e-14 High light scatter reticulocyte count; LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC cis rs6674970 0.966 rs10788800 chr1:151104950 G/A cg11822372 chr1:151115635 SEMA6C 0.54 8.4 0.42 1.32e-15 Childhood ear infection; LUSC cis rs9902453 0.726 rs3110494 chr17:27976597 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.15 0.52 9.7e-25 Coffee consumption (cups per day); LUSC cis rs72634258 0.554 rs35307738 chr1:7919839 C/G cg00042356 chr1:8021962 PARK7 0.6 7.0 0.36 1.41e-11 Inflammatory bowel disease; LUSC cis rs8141529 1.000 rs8141529 chr22:29269692 A/G cg02153584 chr22:29168773 CCDC117 0.58 8.26 0.41 3.38e-15 Lymphocyte counts; LUSC cis rs3760982 0.813 rs10426528 chr19:44299298 A/G cg11993925 chr19:44307056 LYPD5 0.32 7.17 0.37 4.81e-12 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg11764359 chr7:65958608 NA 0.68 10.85 0.51 1.06e-23 Aortic root size; LUSC trans rs1005277 0.522 rs7090858 chr10:38003670 A/C cg17830980 chr10:43048298 ZNF37B 0.41 6.51 0.34 2.81e-10 Extrinsic epigenetic age acceleration; LUSC cis rs6062509 0.895 rs6062497 chr20:62336258 C/T cg01176363 chr20:62369445 LIME1 -0.47 -6.94 -0.36 1.99e-11 Prostate cancer; LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.71 0.3 2.54e-8 Menopause (age at onset); LUSC cis rs68170813 0.559 rs17427849 chr7:106864237 A/G cg02696742 chr7:106810147 HBP1 -0.64 -9.58 -0.46 2.35e-19 Coronary artery disease; LUSC cis rs62408225 1.000 rs2089126 chr6:90970212 A/G cg06866423 chr6:90926672 BACH2 0.4 5.8 0.3 1.58e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7267979 1.000 rs6138572 chr20:25435934 G/C cg08601574 chr20:25228251 PYGB 0.42 6.29 0.33 9.95e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11866815 0.739 rs35050910 chr16:394483 T/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.4 6.14 0.32 2.38e-9 Body mass index; LUSC cis rs12618769 0.597 rs7593615 chr2:99030598 C/A cg10123293 chr2:99228465 UNC50 0.46 7.85 0.39 5.69e-14 Bipolar disorder; LUSC trans rs561341 0.609 rs7209493 chr17:30197323 A/G cg27661571 chr11:113659931 NA 0.51 5.95 0.31 6.61e-9 Hip circumference adjusted for BMI; LUSC cis rs4363385 0.747 rs1999886 chr1:152955522 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.78 -0.39 9.11e-14 Inflammatory skin disease; LUSC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg16325326 chr1:53192061 ZYG11B -0.89 -16.12 -0.66 1.22e-43 Monocyte count; LUSC cis rs11191205 0.865 rs11191161 chr10:103726528 C/T cg15320455 chr10:103880129 LDB1 -0.55 -6.45 -0.33 4.01e-10 Intelligence (multi-trait analysis); LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg26668828 chr6:292823 DUSP22 -0.49 -7.14 -0.36 5.86e-12 Menopause (age at onset); LUSC cis rs12618769 0.597 rs3769719 chr2:99124404 T/C cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -16.24 -0.66 4.09e-44 Prostate cancer; LUSC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg27572855 chr1:25598939 RHD 0.45 8.33 0.41 2.06e-15 Erythrocyte sedimentation rate; LUSC cis rs6977660 0.562 rs12112698 chr7:19781431 A/G cg07541023 chr7:19748670 TWISTNB 0.61 6.47 0.33 3.46e-10 Thyroid stimulating hormone; LUSC cis rs9837602 1.000 rs9833980 chr3:99767096 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 5.64 0.3 3.56e-8 Breast cancer; LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg13560548 chr3:10150139 C3orf24 0.51 7.32 0.37 1.85e-12 Alzheimer's disease; LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg11764359 chr7:65958608 NA 0.54 6.97 0.36 1.75e-11 Aortic root size; LUSC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg06697600 chr4:7070879 GRPEL1 -0.45 -7.31 -0.37 1.97e-12 Monocyte percentage of white cells; LUSC cis rs4845570 1.000 rs4845579 chr1:151770138 C/T cg07092448 chr1:151763213 TDRKH -1.27 -17.53 -0.69 3.03e-49 Coronary artery disease; LUSC cis rs9815354 0.638 rs12634670 chr3:41875299 G/C cg03022575 chr3:42003672 ULK4 0.84 8.86 0.44 4.79e-17 Pulse pressure;Diastolic blood pressure; LUSC trans rs7939886 0.920 rs11231794 chr11:55765776 T/C cg15704280 chr7:45808275 SEPT13 0.78 6.57 0.34 1.94e-10 Myopia (pathological); LUSC cis rs1559088 0.948 rs7259333 chr19:33579128 T/C cg03563238 chr19:33554763 RHPN2 -0.4 -6.33 -0.33 7.81e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs344364 0.602 rs2437745 chr16:1908431 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.41 5.95 0.31 6.68e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.03 0.58 1.12e-31 Chronic sinus infection; LUSC cis rs6570726 1.000 rs444564 chr6:145859795 G/C cg05347473 chr6:146136440 FBXO30 0.4 6.75 0.35 6.37e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs67981189 0.593 rs221919 chr14:71588229 A/G cg15816911 chr14:71606274 NA -0.33 -5.76 -0.3 1.86e-8 Schizophrenia; LUSC cis rs9581857 0.547 rs9581878 chr13:28104552 T/A cg22138327 chr13:27999177 GTF3A 0.67 7.24 0.37 3.08e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs2262909 0.962 rs55728714 chr19:22262899 A/G cg11619707 chr19:22235551 ZNF257 0.39 5.87 0.31 1.04e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7212590 0.748 rs7211208 chr17:57957109 A/C cg10252138 chr17:58120427 NA -0.76 -7.02 -0.36 1.24e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg14440974 chr22:39074834 NA -0.37 -6.09 -0.32 3.17e-9 Menopause (age at onset); LUSC trans rs453301 0.571 rs330054 chr8:9088291 G/A cg08975724 chr8:8085496 FLJ10661 -0.45 -6.6 -0.34 1.65e-10 Joint mobility (Beighton score); LUSC trans rs7980799 0.649 rs1601003 chr12:33689436 A/T cg26384229 chr12:38710491 ALG10B 0.57 8.17 0.41 6.38e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2235573 0.527 rs139862 chr22:38351986 T/C cg06521852 chr22:38141419 TRIOBP -0.35 -5.67 -0.3 3.1e-8 Glioblastoma;Glioma; LUSC cis rs7582180 0.614 rs1530030 chr2:101009600 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.45 -0.42 8.9e-16 Intelligence (multi-trait analysis); LUSC cis rs8017423 0.740 rs7152196 chr14:90703900 G/T cg04374321 chr14:90722782 PSMC1 0.74 11.58 0.54 2.72e-26 Mortality in heart failure; LUSC cis rs9399401 0.626 rs12664563 chr6:142785201 A/G cg03128060 chr6:142623767 GPR126 0.58 9.61 0.47 1.76e-19 Chronic obstructive pulmonary disease; LUSC cis rs6545883 0.929 rs1186700 chr2:61663372 A/C cg15711740 chr2:61764176 XPO1 -0.43 -6.51 -0.34 2.7e-10 Tuberculosis; LUSC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs57920188 0.535 rs7412438 chr1:4095581 C/G cg20703997 chr1:4087676 NA 0.56 7.97 0.4 2.62e-14 Interleukin-17 levels; LUSC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -5.99 -0.31 5.51e-9 Life satisfaction; LUSC cis rs2742417 0.532 rs2742424 chr3:45735218 A/G cg09608765 chr3:45636137 LIMD1 0.35 6.44 0.33 4.21e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg00945038 chr17:61921165 SMARCD2 -0.46 -7.82 -0.39 7.15e-14 Prudent dietary pattern; LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg22920501 chr2:26401640 FAM59B 0.82 12.46 0.56 1.59e-29 Gut microbiome composition (summer); LUSC cis rs12579753 0.869 rs12366921 chr12:82223024 G/A cg21231944 chr12:82153410 PPFIA2 -0.39 -5.91 -0.31 8.57e-9 Resting heart rate; LUSC cis rs6754311 0.731 rs10207652 chr2:136588478 T/A cg25344623 chr2:136566232 LCT 0.4 5.98 0.31 5.74e-9 Mosquito bite size; LUSC cis rs8114671 0.562 rs6088647 chr20:33505997 T/C cg08999081 chr20:33150536 PIGU 0.32 5.65 0.3 3.51e-8 Height; LUSC cis rs477692 0.569 rs1771448 chr10:131296201 A/G cg05714579 chr10:131428358 MGMT -0.39 -5.73 -0.3 2.19e-8 Response to temozolomide; LUSC cis rs3736594 0.918 rs9677663 chr2:27972445 G/A cg27432699 chr2:27873401 GPN1 -0.64 -9.07 -0.44 1.07e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg04450456 chr4:17643702 FAM184B 0.39 6.78 0.35 5.59e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg10578991 chr7:12443926 VWDE -0.47 -5.71 -0.3 2.53e-8 Coronary artery disease; LUSC cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg00631329 chr6:26305371 NA -0.47 -9.36 -0.46 1.25e-18 Educational attainment; LUSC cis rs6500395 1.000 rs2883475 chr16:48560315 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.42 0.33 4.56e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9314323 0.698 rs1064807 chr8:26236978 C/T cg11498726 chr8:26250323 BNIP3L -0.46 -6.7 -0.34 9.02e-11 Red cell distribution width; LUSC cis rs7582720 1.000 rs116678869 chr2:203819471 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs911555 0.692 rs7146215 chr14:103915908 A/G cg24130564 chr14:104152367 KLC1 0.45 6.53 0.34 2.43e-10 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.2 -0.41 5.08e-15 Neuroticism; LUSC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg07636037 chr3:49044803 WDR6 0.43 6.18 0.32 1.84e-9 Resting heart rate; LUSC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg18876405 chr7:65276391 NA 0.55 8.74 0.43 1.19e-16 Aortic root size; LUSC cis rs35146811 0.657 rs36019559 chr7:99814586 A/G cg19116668 chr7:99932089 PMS2L1 0.34 5.95 0.31 6.8e-9 Coronary artery disease; LUSC cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg07606381 chr6:8435919 SLC35B3 0.72 12.14 0.55 2.35e-28 Motion sickness; LUSC cis rs3812762 0.917 rs2873297 chr11:8791227 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.39 6.63 0.34 1.35e-10 Hypospadias; LUSC cis rs10779751 1.000 rs1010447 chr1:11269796 A/G cg08854313 chr1:11322531 MTOR 0.83 14.56 0.62 1.52e-37 Body mass index; LUSC cis rs713587 0.967 rs713586 chr2:25158008 A/G cg01884057 chr2:25150051 NA 0.46 11.1 0.52 1.46e-24 Body mass index in non-asthmatics; LUSC cis rs9788721 0.967 rs72740955 chr15:78849779 C/T cg18825076 chr15:78729989 IREB2 -0.5 -7.6 -0.38 2.93e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg01849466 chr14:104193079 ZFYVE21 -0.56 -9.02 -0.44 1.48e-17 Schizophrenia; LUSC cis rs60012524 1 rs60012524 chr2:99559117 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -8.53 -0.42 5.21e-16 Chronic sinus infection; LUSC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg15556689 chr8:8085844 FLJ10661 -0.56 -8.34 -0.42 1.93e-15 Neuroticism; LUSC cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg24642439 chr20:33292090 TP53INP2 0.7 11.34 0.53 1.97e-25 Coronary artery disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23690355 chr15:44719213 CTDSPL2 0.44 6.69 0.34 9.34e-11 Triglycerides; LUSC cis rs2361710 1.000 rs2361710 chr17:78111877 C/T cg20811857 chr17:78079795 GAA 0.29 5.66 0.3 3.18e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC trans rs6480314 0.542 rs17231637 chr10:70029894 C/T cg04882175 chr6:131122610 NA 0.51 5.99 0.31 5.43e-9 Optic nerve measurement (disc area); LUSC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC trans rs11700980 0.551 rs2832012 chr21:30110932 C/T cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.41e-9 QRS complex (12-leadsum); LUSC cis rs751728 1.000 rs3793079 chr6:33767788 T/A cg25922239 chr6:33757077 LEMD2 0.53 7.83 0.39 6.45e-14 Crohn's disease; LUSC cis rs11645898 0.810 rs72787085 chr16:72182564 C/T cg14768367 chr16:72042858 DHODH -0.65 -7.11 -0.36 7.28e-12 Blood protein levels; LUSC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg04414720 chr1:150670196 GOLPH3L -0.48 -7.19 -0.37 4.37e-12 Blood protein levels; LUSC cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs17253792 0.822 rs79291233 chr14:56065302 G/C cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs7512552 0.839 rs11577843 chr1:150398258 A/G cg15654264 chr1:150340011 RPRD2 0.61 10.04 0.48 6.57e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs61931739 0.500 rs11053189 chr12:34433455 G/A cg06521331 chr12:34319734 NA -0.4 -6.26 -0.32 1.2e-9 Morning vs. evening chronotype; LUSC cis rs4555082 0.834 rs11622165 chr14:105759761 C/A cg13114125 chr14:105738426 BRF1 -0.92 -14.78 -0.63 2.28e-38 Mean platelet volume;Platelet distribution width; LUSC cis rs9303401 0.659 rs36093395 chr17:56957357 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.18 0.58 3.19e-32 Cognitive test performance; LUSC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg13206674 chr6:150067644 NUP43 0.6 9.45 0.46 6.24e-19 Lung cancer; LUSC cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs1801251 1.000 rs6745879 chr2:233590007 A/G cg08000102 chr2:233561755 GIGYF2 0.68 11.42 0.53 1.04e-25 Coronary artery disease; LUSC cis rs7829975 0.591 rs12677543 chr8:8644274 G/C cg15556689 chr8:8085844 FLJ10661 0.65 10.36 0.49 5.51e-22 Mood instability; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22713327 chr12:120703336 PXN -0.49 -6.27 -0.32 1.09e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg11062466 chr8:58055876 NA -0.73 -8.85 -0.44 5.2e-17 Developmental language disorder (linguistic errors); LUSC cis rs1372520 0.808 rs1372518 chr4:90757294 A/C cg15133208 chr4:90757351 SNCA -0.57 -8.74 -0.43 1.12e-16 Neuroticism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12904531 chr11:67572716 LOC645332 0.76 6.18 0.32 1.91e-9 Cognitive performance; LUSC cis rs7089973 0.836 rs1966384 chr10:116627910 G/T cg23260525 chr10:116636907 FAM160B1 0.4 8.21 0.41 4.95e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.37 0.33 6.36e-10 Mean platelet volume; LUSC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg18225595 chr11:63971243 STIP1 -0.57 -9.19 -0.45 4.35e-18 Platelet count; LUSC cis rs75920871 0.528 rs12274465 chr11:116957189 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.48 -6.1 -0.32 2.9e-9 Subjective well-being; LUSC cis rs4285028 0.696 rs3915060 chr3:121712980 C/T cg11130432 chr3:121712080 ILDR1 0.71 11.61 0.54 2.08e-26 Multiple sclerosis; LUSC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg09650180 chr20:62225654 GMEB2 -0.66 -9.53 -0.46 3.46e-19 Glioblastoma; LUSC cis rs7267979 1.000 rs6050564 chr20:25344231 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3859192 0.539 rs2302774 chr17:38183090 G/T cg17467752 chr17:38218738 THRA -0.5 -7.0 -0.36 1.37e-11 White blood cell count; LUSC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg03678062 chr6:149772716 ZC3H12D 0.33 6.83 0.35 3.93e-11 Dupuytren's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00252696 chr1:31769601 ZCCHC17;SNRNP40 -0.46 -6.02 -0.31 4.58e-9 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.48 0.53 5.96e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs4776059 1.000 rs35372377 chr15:52882281 G/A cg25063058 chr15:52860530 ARPP19 0.45 6.18 0.32 1.9e-9 Schizophrenia; LUSC cis rs4631830 0.720 rs2611475 chr10:51503178 G/A cg20129853 chr10:51489980 NA -0.36 -7.56 -0.38 3.84e-13 Prostate-specific antigen levels; LUSC cis rs7561273 0.586 rs6545264 chr2:24310105 A/G cg20701182 chr2:24300061 SF3B14 0.5 6.47 0.33 3.57e-10 Quantitative traits; LUSC cis rs854765 0.594 rs8066560 chr17:17728043 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.7 -11.51 -0.53 4.74e-26 Total body bone mineral density; LUSC cis rs7829975 0.711 rs4481596 chr8:8704330 G/C cg08975724 chr8:8085496 FLJ10661 0.55 8.21 0.41 4.91e-15 Mood instability; LUSC cis rs4595586 0.545 rs7973338 chr12:39380704 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs3820068 0.608 rs7552400 chr1:16035892 A/G cg13390004 chr1:15929781 NA 0.41 6.79 0.35 5.02e-11 Systolic blood pressure; LUSC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg24733560 chr20:60626293 TAF4 0.44 8.05 0.4 1.47e-14 Body mass index; LUSC cis rs7264396 0.836 rs6088880 chr20:34165582 G/C cg04508476 chr20:34239394 CPNE1;RBM12 0.52 7.77 0.39 9.46e-14 Total cholesterol levels; LUSC trans rs445114 0.509 rs432523 chr8:128337927 A/T cg10195415 chr17:73887371 TRIM65 0.42 6.73 0.35 7.51e-11 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg17971929 chr21:40555470 PSMG1 0.8 14.01 0.61 2.13e-35 Cognitive function; LUSC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg01475377 chr6:109611718 NA -0.44 -7.84 -0.39 6.06e-14 Reticulocyte fraction of red cells; LUSC cis rs2115630 1.000 rs8037423 chr15:85355494 C/T cg09876464 chr15:85330779 ZNF592 0.36 6.67 0.34 1.07e-10 P wave terminal force; LUSC cis rs600231 0.651 rs2846862 chr11:65219790 A/G cg17120908 chr11:65337727 SSSCA1 -0.52 -9.32 -0.45 1.58e-18 Bone mineral density; LUSC cis rs7119038 0.818 rs76704408 chr11:118683327 G/T cg19308663 chr11:118741387 NA 0.34 5.93 0.31 7.36e-9 Sjögren's syndrome; LUSC cis rs4499344 0.658 rs10415040 chr19:33052706 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.79 -10.17 -0.49 2.46e-21 Mean platelet volume; LUSC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg18305652 chr10:134549665 INPP5A -0.42 -6.49 -0.33 3.13e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6582630 0.548 rs1607870 chr12:38385964 G/T cg13010199 chr12:38710504 ALG10B -0.45 -6.72 -0.35 7.76e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg04315214 chr1:2043799 PRKCZ -0.38 -7.47 -0.38 7.08e-13 Height; LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.55 -8.02 -0.4 1.86e-14 Alzheimer's disease (late onset); LUSC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.87 0.6 7.44e-35 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3008870 1.000 rs1137656 chr1:67451602 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs62244186 0.566 rs2135531 chr3:44881158 C/G cg02073558 chr3:44770973 ZNF501 0.56 8.91 0.44 3.39e-17 Depressive symptoms; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg13560548 chr3:10150139 C3orf24 0.52 7.12 0.36 6.49e-12 Alzheimer's disease; LUSC cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.79 -0.57 9.51e-31 Chronic sinus infection; LUSC cis rs35146811 0.735 rs2272344 chr7:99786819 C/T cg13334819 chr7:99746414 C7orf59 -0.5 -6.73 -0.35 7.41e-11 Coronary artery disease; LUSC cis rs394563 0.591 rs237028 chr6:149718650 C/T cg07828024 chr6:149772892 ZC3H12D -0.33 -7.3 -0.37 2.12e-12 Dupuytren's disease; LUSC cis rs1018836 0.923 rs13268594 chr8:91588545 G/T cg16814680 chr8:91681699 NA -0.75 -12.36 -0.56 3.69e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6674970 0.627 rs2864700 chr1:151028929 C/T cg03258749 chr1:151040405 MLLT11 -0.38 -6.22 -0.32 1.5e-9 Childhood ear infection; LUSC cis rs7568458 0.709 rs2592551 chr2:85780131 G/A cg23752985 chr2:85803571 VAMP8 0.32 6.2 0.32 1.7e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs8114671 0.562 rs2424999 chr20:33386430 G/A cg24642439 chr20:33292090 TP53INP2 0.54 8.12 0.41 9.31e-15 Height; LUSC cis rs11997175 0.624 rs7465686 chr8:33718321 G/A ch.8.33884649F chr8:33765107 NA 0.42 5.91 0.31 8.61e-9 Body mass index; LUSC cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg17892150 chr10:133769511 PPP2R2D -0.68 -9.46 -0.46 5.56e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg15445000 chr17:37608096 MED1 0.39 6.74 0.35 6.89e-11 Glomerular filtration rate (creatinine); LUSC cis rs7605378 0.752 rs769960 chr2:200710706 G/T cg23649088 chr2:200775458 C2orf69 -0.64 -10.07 -0.48 5.22e-21 Osteoporosis; LUSC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg18876405 chr7:65276391 NA 0.58 9.34 0.45 1.45e-18 Aortic root size; LUSC cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.87 0.4 4.92e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1670533 1.000 rs1670534 chr4:1087265 T/C cg02018176 chr4:1364513 KIAA1530 0.47 6.42 0.33 4.72e-10 Recombination rate (females); LUSC cis rs9467603 1.000 rs9461216 chr6:25808743 A/T cg08501292 chr6:25962987 TRIM38 0.67 5.69 0.3 2.72e-8 Intelligence (multi-trait analysis); LUSC cis rs67311347 0.544 rs6769627 chr3:40327845 G/A cg13683864 chr3:40499215 RPL14 -0.77 -12.77 -0.57 1.1e-30 Renal cell carcinoma; LUSC cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg08999081 chr20:33150536 PIGU 0.51 10.22 0.49 1.58e-21 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg23711669 chr6:146136114 FBXO30 0.85 15.47 0.65 4.32e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 0.967 rs34344935 chr7:91835436 G/A cg17063962 chr7:91808500 NA 0.59 8.99 0.44 1.82e-17 Breast cancer; LUSC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg05729581 chr11:3078854 CARS -0.53 -7.9 -0.4 4.01e-14 Type 2 diabetes; LUSC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg20203395 chr5:56204925 C5orf35 -0.56 -7.81 -0.39 7.65e-14 Initial pursuit acceleration; LUSC cis rs1506636 0.962 rs7811830 chr7:123320183 G/C cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs1461503 0.966 rs10892938 chr11:122841921 A/C cg27398637 chr11:122830231 C11orf63 -0.41 -6.53 -0.34 2.4e-10 Menarche (age at onset); LUSC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg07701084 chr6:150067640 NUP43 0.55 8.33 0.41 2.1e-15 Lung cancer; LUSC cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.67 8.33 0.41 2.08e-15 Schizophrenia; LUSC cis rs7927771 0.839 rs3817334 chr11:47650993 C/T cg18512352 chr11:47633146 NA -0.43 -8.9 -0.44 3.56e-17 Subjective well-being; LUSC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg19592336 chr6:28129416 ZNF389 0.47 6.19 0.32 1.75e-9 Depression; LUSC cis rs73198271 0.740 rs1039911 chr8:8648206 G/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.27 -0.32 1.13e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg03690763 chr11:133734501 NA 0.31 5.69 0.3 2.82e-8 Childhood ear infection; LUSC cis rs11583043 0.958 rs12730160 chr1:101438791 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.43 5.87 0.31 1.04e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs950169 0.840 rs62019457 chr15:85102142 T/C cg17507749 chr15:85114479 UBE2QP1 0.71 9.32 0.45 1.62e-18 Schizophrenia; LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg07424592 chr7:64974309 NA -0.45 -6.29 -0.33 9.76e-10 Calcium levels; LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.7 -0.43 1.57e-16 Bipolar disorder; LUSC cis rs2635047 0.783 rs9948677 chr18:44790343 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 5.76 0.3 1.94e-8 Educational attainment; LUSC cis rs17253792 0.915 rs78498383 chr14:56177585 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs11166629 0.883 rs11778878 chr8:135599220 C/T cg27224718 chr8:135614730 ZFAT -0.61 -9.9 -0.48 2.02e-20 Smoking quantity; LUSC cis rs1595825 0.891 rs79745588 chr2:198516835 G/A cg19156104 chr2:198669113 PLCL1 -0.46 -5.84 -0.3 1.24e-8 Ulcerative colitis; LUSC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.5 7.83 0.39 6.75e-14 Cognitive test performance; LUSC cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg17340268 chr14:105411764 AHNAK2 -0.38 -6.12 -0.32 2.58e-9 Rheumatoid arthritis; LUSC cis rs7804356 1.000 rs3801812 chr7:26887615 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.13e-8 Breast cancer; LUSC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.76e-9 Aortic root size; LUSC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg21361702 chr7:150065534 REPIN1 0.49 6.53 0.34 2.42e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs778371 0.723 rs12105766 chr2:233617647 A/G cg08000102 chr2:233561755 GIGYF2 0.8 13.0 0.58 1.44e-31 Schizophrenia; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg20887711 chr4:1340912 KIAA1530 0.72 11.96 0.55 1.12e-27 Longevity; LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg18357526 chr6:26021779 HIST1H4A 0.46 7.24 0.37 3.06e-12 Intelligence (multi-trait analysis); LUSC cis rs17095355 1.000 rs12254785 chr10:111699607 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.6 -0.38 2.95e-13 Biliary atresia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09775628 chr19:1479573 C19orf25 0.73 6.02 0.31 4.67e-9 Cognitive performance; LUSC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg09267113 chr7:98030324 BAIAP2L1 0.39 5.92 0.31 7.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs701145 0.938 rs165275 chr3:153991875 T/C cg17054900 chr3:154042577 DHX36 0.82 8.52 0.42 5.56e-16 Coronary artery disease; LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg16405210 chr4:1374714 KIAA1530 -0.66 -10.69 -0.51 3.78e-23 Longevity; LUSC trans rs4332037 0.754 rs62436669 chr7:1926636 G/A cg25206134 chr2:45395956 NA 0.58 6.33 0.33 7.73e-10 Bipolar disorder; LUSC trans rs8072100 1.000 rs11650372 chr17:45721795 G/A cg03886242 chr7:26192032 NFE2L3 -0.37 -6.08 -0.32 3.32e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs77956314 0.818 rs12296869 chr12:117431203 G/A cg02017074 chr12:117425053 FBXW8 -0.66 -6.57 -0.34 1.88e-10 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs6688613 0.649 rs11584352 chr1:166850372 T/C cg07049167 chr1:166818506 POGK 0.48 6.72 0.35 7.69e-11 Refractive astigmatism; LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC cis rs13315871 0.929 rs13097873 chr3:58267924 C/T cg20936604 chr3:58311152 NA -0.75 -6.97 -0.36 1.7e-11 Cholesterol, total; LUSC cis rs7772486 0.558 rs2142980 chr6:146080679 G/A cg05347473 chr6:146136440 FBXO30 -0.6 -9.27 -0.45 2.3e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs7980799 0.682 rs7138529 chr12:33634855 T/C cg26384229 chr12:38710491 ALG10B -0.58 -8.61 -0.43 2.9e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg24250549 chr1:154909240 PMVK 0.63 10.2 0.49 1.89e-21 Prostate cancer; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg06873352 chr17:61820015 STRADA 0.7 12.58 0.57 5.73e-30 Prudent dietary pattern; LUSC cis rs7914558 1.000 rs1926030 chr10:104855656 T/C cg04362960 chr10:104952993 NT5C2 0.59 9.4 0.46 9.21e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.64 0.63 8.06e-38 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg26384229 chr12:38710491 ALG10B 0.88 15.14 0.64 8.97e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs11608355 0.515 rs12833054 chr12:109890955 G/A cg05360138 chr12:110035743 NA 0.81 8.76 0.43 1.02e-16 Neuroticism; LUSC cis rs950169 0.922 rs11638445 chr15:85137694 C/A cg12863693 chr15:85201151 NMB 0.35 6.8 0.35 4.73e-11 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21956150 chr19:1438388 RPS15 -0.53 -6.81 -0.35 4.43e-11 Bipolar disorder and schizophrenia; LUSC cis rs7582720 1.000 rs72934710 chr2:203709776 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.73 8.0 0.4 2.12e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg14416269 chr4:6271139 WFS1 0.54 11.47 0.53 6.76e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs62238980 0.614 rs117017176 chr22:32400725 T/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs7264396 0.635 rs6119672 chr20:34479767 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.8 -0.43 7.25e-17 Total cholesterol levels; LUSC cis rs10752881 1.000 rs8179262 chr1:182973186 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 10.49 0.5 1.98e-22 Colorectal cancer; LUSC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg17294928 chr15:75287854 SCAMP5 0.41 5.99 0.31 5.56e-9 Breast cancer; LUSC cis rs9322817 0.691 rs9391249 chr6:105343433 T/A cg02098413 chr6:105308735 HACE1 0.28 5.96 0.31 6.43e-9 Thyroid stimulating hormone; LUSC cis rs977987 0.806 rs8054769 chr16:75401113 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.94 -0.36 2e-11 Dupuytren's disease; LUSC cis rs7180079 0.502 rs8033972 chr15:64524980 G/A cg02848875 chr15:64387786 SNX1 -0.41 -8.0 -0.4 2.02e-14 Monocyte count; LUSC cis rs7119 0.931 rs62009087 chr15:77833064 C/T cg27398640 chr15:77910606 LINGO1 -0.32 -7.22 -0.37 3.58e-12 Type 2 diabetes; LUSC cis rs1775715 0.707 rs2065443 chr10:32164236 C/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.65 0.34 1.19e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Melanoma; LUSC cis rs72781680 0.821 rs17038360 chr2:24095798 A/G cg08917208 chr2:24149416 ATAD2B 0.6 6.98 0.36 1.59e-11 Lymphocyte counts; LUSC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg17264618 chr3:40429014 ENTPD3 0.31 6.78 0.35 5.39e-11 Renal cell carcinoma; LUSC cis rs240764 0.658 rs12194255 chr6:101168439 G/A cg09795085 chr6:101329169 ASCC3 -0.42 -6.03 -0.31 4.42e-9 Neuroticism; LUSC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg21433313 chr16:3507492 NAT15 0.65 10.84 0.51 1.14e-23 Tuberculosis; LUSC cis rs727505 1.000 rs59294613 chr7:124554267 C/A cg23710748 chr7:124431027 NA -0.4 -7.15 -0.36 5.64e-12 Lewy body disease; LUSC cis rs10450586 0.863 rs7126943 chr11:27303937 A/G cg08958251 chr11:27270390 NA -0.36 -5.78 -0.3 1.76e-8 Total body bone mineral density; LUSC cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs600231 0.613 rs12803915 chr11:65211979 G/A cg17120908 chr11:65337727 SSSCA1 -0.67 -9.33 -0.45 1.46e-18 Bone mineral density; LUSC cis rs9300255 0.507 rs1727302 chr12:123632930 G/A cg00376283 chr12:123451042 ABCB9 0.72 10.08 0.48 5.06e-21 Neutrophil percentage of white cells; LUSC cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg00321850 chr1:175162397 KIAA0040 0.45 7.35 0.37 1.52e-12 Alcohol dependence; LUSC cis rs11758351 0.588 rs2050948 chr6:26234952 A/G cg23601095 chr6:26197514 HIST1H3D 0.69 7.46 0.38 7.54e-13 Gout;Renal underexcretion gout; LUSC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg18904891 chr8:8559673 CLDN23 0.56 7.76 0.39 1.04e-13 Obesity-related traits; LUSC trans rs6089829 0.926 rs6011552 chr20:61667894 T/C cg23505145 chr19:12996616 KLF1 0.65 10.82 0.51 1.38e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs2885056 0.783 rs73007347 chr19:10650649 C/T cg04833646 chr19:10679720 CDKN2D 1.15 16.63 0.67 1.2e-45 Red cell distribution width; LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs9300255 0.602 rs2851438 chr12:123643689 T/C cg05973401 chr12:123451056 ABCB9 0.54 6.67 0.34 1.06e-10 Neutrophil percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18825258 chr8:26435354 DPYSL2 -0.42 -6.04 -0.31 4.09e-9 Electrocardiographic conduction measures; LUSC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg12365402 chr11:9010492 NRIP3 -0.48 -8.98 -0.44 1.98e-17 Hemoglobin concentration; LUSC cis rs9341835 0.518 rs9344168 chr6:64169682 G/A cg03326410 chr6:64151739 NA -0.37 -6.01 -0.31 4.85e-9 Schizophrenia; LUSC cis rs4280164 0.578 rs17184689 chr14:24794440 A/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.57 -7.45 -0.38 8.28e-13 Parent of origin effect on language impairment (paternal); LUSC cis rs4561483 0.582 rs35063476 chr16:12044301 A/G cg08843971 chr16:11963173 GSPT1 -0.42 -5.98 -0.31 5.8e-9 Testicular germ cell tumor; LUSC cis rs2239815 0.515 rs5762849 chr22:29238086 G/A cg02153584 chr22:29168773 CCDC117 0.55 6.34 0.33 7.34e-10 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs8056893 0.714 rs7192234 chr16:68391189 C/G cg02226672 chr16:68398533 SMPD3 0.33 5.85 0.31 1.15e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs6977660 0.507 rs72591449 chr7:19775443 T/C cg07541023 chr7:19748670 TWISTNB 0.81 8.03 0.4 1.67e-14 Thyroid stimulating hormone; LUSC cis rs61931739 0.534 rs1490109 chr12:34064077 T/C cg06521331 chr12:34319734 NA -0.52 -8.45 -0.42 9.35e-16 Morning vs. evening chronotype; LUSC trans rs7613875 0.600 rs2856237 chr3:50158774 A/G cg21659725 chr3:3221576 CRBN -0.53 -8.33 -0.41 2.1e-15 Body mass index; LUSC cis rs9814567 1.000 rs13071551 chr3:134310867 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.63 0.34 1.36e-10 Menarche (age at onset); LUSC cis rs3099143 1.000 rs901008 chr15:77097018 C/A cg21673338 chr15:77095150 SCAPER -0.79 -7.59 -0.38 3.29e-13 Recalcitrant atopic dermatitis; LUSC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg26441486 chr22:50317300 CRELD2 0.53 8.07 0.4 1.27e-14 Schizophrenia; LUSC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg12560992 chr17:57184187 TRIM37 0.82 14.75 0.63 2.92e-38 Intelligence (multi-trait analysis); LUSC cis rs9905704 0.560 rs2526375 chr17:56429094 A/G cg19466818 chr17:56409534 MIR142 -0.37 -6.54 -0.34 2.26e-10 Testicular germ cell tumor; LUSC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg22437258 chr11:111473054 SIK2 0.5 6.83 0.35 4.12e-11 Primary sclerosing cholangitis; LUSC cis rs2455601 0.786 rs3751064 chr11:8958903 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -8.33 -0.41 2.14e-15 Schizophrenia; LUSC cis rs868036 1.000 rs868037 chr15:68054996 A/G cg08079166 chr15:68083412 MAP2K5 -0.42 -8.57 -0.42 3.98e-16 Restless legs syndrome; LUSC cis rs7267979 1.000 rs3761117 chr20:25388070 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.51 -0.34 2.68e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs377070 0.966 rs368931 chr4:123631597 G/T cg10495464 chr4:123653540 BBS12;LOC729338 0.47 6.84 0.35 3.82e-11 Mosquito bite size; LUSC cis rs9467711 0.790 rs13198716 chr6:26582035 A/G cg09904177 chr6:26538194 HMGN4 0.79 6.25 0.32 1.24e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9814567 0.806 rs12637301 chr3:134317966 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.39 -0.56 2.98e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg22166914 chr1:53195759 ZYG11B 0.68 11.37 0.53 1.55e-25 Monocyte count; LUSC cis rs7584330 0.822 rs13390494 chr2:238388792 G/A cg14458575 chr2:238380390 NA 0.67 11.5 0.53 5.33e-26 Prostate cancer; LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg11645453 chr3:52864694 ITIH4 0.35 7.88 0.4 4.52e-14 Bipolar disorder; LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg04267008 chr7:1944627 MAD1L1 -0.51 -7.73 -0.39 1.24e-13 Bipolar disorder and schizophrenia; LUSC cis rs4285028 0.948 rs13083557 chr3:121687613 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.68 -0.47 1.07e-19 Multiple sclerosis; LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg23758822 chr17:41437982 NA 1.06 20.25 0.74 4.64e-60 Menopause (age at onset); LUSC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg21862992 chr11:68658383 NA 0.5 7.98 0.4 2.35e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg17971929 chr21:40555470 PSMG1 -0.68 -11.29 -0.53 2.91e-25 Cognitive function; LUSC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg04111992 chr7:158790115 NA -0.45 -7.19 -0.37 4.2e-12 Facial morphology (factor 20); LUSC cis rs4478858 0.611 rs7527645 chr1:31763787 T/C cg00250761 chr1:31883323 NA -0.33 -7.95 -0.4 2.9e-14 Alcohol dependence; LUSC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg21951975 chr1:209979733 IRF6 0.59 7.01 0.36 1.3e-11 Cleft lip with or without cleft palate; LUSC cis rs7177699 0.557 rs11072807 chr15:79111517 A/G cg15571903 chr15:79123663 NA 0.33 6.02 0.31 4.57e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs3850699 0.651 rs35485301 chr10:104370827 C/T cg05855489 chr10:104503620 C10orf26 0.71 9.49 0.46 4.54e-19 Prostate cancer; LUSC cis rs3806843 1.000 rs1476768 chr5:140173597 G/A cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.43e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg25554036 chr4:6271136 WFS1 0.58 11.94 0.55 1.29e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg18876405 chr7:65276391 NA 0.53 8.2 0.41 5.2e-15 Aortic root size; LUSC cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg12573674 chr2:1569213 NA -0.56 -7.97 -0.4 2.61e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg11366901 chr6:160182831 ACAT2 0.93 12.71 0.57 1.81e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg03806693 chr22:41940476 POLR3H 0.94 13.57 0.6 1.01e-33 Vitiligo; LUSC trans rs17685 0.753 rs4728550 chr7:75670988 C/A cg19862616 chr7:65841803 NCRNA00174 -1.14 -20.32 -0.74 2.42e-60 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9300255 0.722 rs34997336 chr12:123829116 G/A cg13010344 chr12:123464640 ARL6IP4 0.49 6.44 0.33 4.06e-10 Neutrophil percentage of white cells; LUSC cis rs11105298 0.891 rs4842661 chr12:89930399 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.12 -0.36 6.5e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg17143192 chr8:8559678 CLDN23 -0.37 -5.77 -0.3 1.82e-8 Mood instability; LUSC cis rs11785400 1.000 rs754957 chr8:143746416 A/G cg24634471 chr8:143751801 JRK 0.6 9.06 0.44 1.13e-17 Schizophrenia; LUSC cis rs7043114 0.525 rs10283572 chr9:95133074 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.58 -0.34 1.85e-10 Height; LUSC cis rs262150 0.659 rs2730275 chr7:158793397 A/G cg04111992 chr7:158790115 NA -0.47 -7.5 -0.38 5.69e-13 Facial morphology (factor 20); LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs56399783 0.901 rs12540539 chr7:2873294 C/T cg19731401 chr7:2775893 GNA12 0.68 9.05 0.44 1.19e-17 Childhood ear infection; LUSC cis rs7589342 0.536 rs10167046 chr2:106386764 A/G cg09152813 chr2:106391379 NCK2 -0.37 -6.07 -0.32 3.43e-9 Addiction; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09644986 chr12:6644356 GAPDH -0.48 -7.07 -0.36 9.1e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg03517284 chr6:25882590 NA -0.56 -9.31 -0.45 1.76e-18 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg04414720 chr1:150670196 GOLPH3L 0.51 7.87 0.4 5.1e-14 Melanoma; LUSC cis rs2573652 0.674 rs11630583 chr15:100543355 G/A cg00587665 chr15:100533223 ADAMTS17 -0.35 -6.25 -0.32 1.22e-9 Height; LUSC cis rs4666002 0.956 rs34502053 chr2:27854524 G/A cg27432699 chr2:27873401 GPN1 0.43 5.85 0.3 1.2e-8 Phospholipid levels (plasma); LUSC cis rs7937682 0.602 rs503905 chr11:111390762 G/C cg09085632 chr11:111637200 PPP2R1B -0.63 -8.53 -0.42 5.09e-16 Primary sclerosing cholangitis; LUSC trans rs12310956 0.510 rs2054867 chr12:33835462 C/G cg13010199 chr12:38710504 ALG10B -0.47 -7.35 -0.37 1.51e-12 Morning vs. evening chronotype; LUSC trans rs1347297 0.526 rs919177 chr2:179258923 C/T cg14011486 chr1:26737247 LIN28 0.42 6.62 0.34 1.4e-10 Alzheimer disease and age of onset; LUSC cis rs12956009 0.583 rs7240132 chr18:44858634 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -6.26 -0.32 1.15e-9 Educational attainment (years of education); LUSC cis rs9325144 0.554 rs7960616 chr12:39096664 T/A cg26384229 chr12:38710491 ALG10B -0.62 -9.68 -0.47 1.06e-19 Morning vs. evening chronotype; LUSC cis rs12579753 0.917 rs7972839 chr12:82178920 C/T cg21231944 chr12:82153410 PPFIA2 -0.37 -5.78 -0.3 1.74e-8 Resting heart rate; LUSC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs6089584 0.927 rs11697597 chr20:60584748 C/T cg13770153 chr20:60521292 NA -0.61 -8.4 -0.42 1.32e-15 Body mass index; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg20295408 chr7:1910781 MAD1L1 -0.49 -6.88 -0.35 3.05e-11 Bipolar disorder and schizophrenia; LUSC trans rs3960554 0.610 rs11971800 chr7:75731608 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 9.75 0.47 6.12e-20 Eotaxin levels; LUSC cis rs12458462 0.892 rs2242174 chr18:77458037 T/C cg11879182 chr18:77439856 CTDP1 0.72 11.93 0.55 1.37e-27 Monocyte count; LUSC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.63 -0.39 2.43e-13 Aortic root size; LUSC cis rs6499755 0.932 rs1370386 chr16:55340167 G/C cg02859129 chr16:55357253 IRX6 0.36 6.07 0.32 3.52e-9 Hypospadias; LUSC cis rs12364620 1 rs12364620 chr11:68252123 T/G cg16797656 chr11:68205561 LRP5 0.37 6.05 0.31 3.96e-9 Total body bone mineral density (age 0-15); LUSC cis rs12155623 1.000 rs12155623 chr8:49812201 A/T cg22283653 chr8:49824208 NA -0.38 -8.09 -0.4 1.08e-14 Sudden cardiac arrest; LUSC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg20933634 chr6:27740509 NA 0.42 6.12 0.32 2.63e-9 Parkinson's disease; LUSC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg05425664 chr17:57184151 TRIM37 -0.56 -8.29 -0.41 2.82e-15 Intelligence (multi-trait analysis); LUSC cis rs1113500 0.897 rs11185263 chr1:108639804 C/G cg06207961 chr1:108661230 NA 0.42 7.71 0.39 1.42e-13 Growth-regulated protein alpha levels; LUSC cis rs7954584 0.583 rs10770186 chr12:122361412 A/G cg22618164 chr12:122356400 WDR66 0.55 7.8 0.39 8.09e-14 Mean corpuscular volume; LUSC cis rs3018712 0.532 rs2513282 chr11:68418311 A/C cg22747802 chr11:68417633 NA -0.41 -5.65 -0.3 3.5e-8 Total body bone mineral density; LUSC cis rs9400467 0.528 rs6568680 chr6:111776164 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.97 -0.36 1.73e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs2798269 1.000 rs4770172 chr13:22123676 A/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.1 -0.32 2.93e-9 PR segment; LUSC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg26850624 chr5:429559 AHRR -0.42 -8.18 -0.41 6.16e-15 Cystic fibrosis severity; LUSC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg11247378 chr22:39784982 NA -0.64 -12.57 -0.57 6.06e-30 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.545 rs8057119 chr16:68268836 C/T cg09835421 chr16:68378352 PRMT7 -0.57 -6.28 -0.32 1.08e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg03354898 chr7:1950403 MAD1L1 0.32 6.36 0.33 6.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs11155671 0.530 rs9968871 chr6:150209196 G/A cg07701084 chr6:150067640 NUP43 0.47 6.92 0.35 2.31e-11 Testicular germ cell tumor; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15202378 chr1:180199443 LHX4 0.46 6.6 0.34 1.62e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4930103 0.874 rs80047492 chr11:2025032 A/T cg06197492 chr11:2016605 H19 0.36 5.84 0.3 1.22e-8 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg02017074 chr12:117425053 FBXW8 0.7 8.03 0.4 1.69e-14 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg24733560 chr20:60626293 TAF4 0.41 6.7 0.34 8.69e-11 Body mass index; LUSC cis rs4660306 0.677 rs6429566 chr1:45941852 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -6.1 -0.32 2.93e-9 Homocysteine levels; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg24101359 chr6:42928495 GNMT 0.37 6.07 0.32 3.5e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6495122 0.651 rs11636952 chr15:75114322 T/C cg14664628 chr15:75095509 CSK -0.76 -12.18 -0.55 1.71e-28 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs778371 0.834 rs778363 chr2:233778896 A/G cg08000102 chr2:233561755 GIGYF2 -0.56 -7.09 -0.36 8.09e-12 Schizophrenia; LUSC trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg27661571 chr11:113659931 NA -0.69 -7.91 -0.4 3.77e-14 Hip circumference adjusted for BMI; LUSC cis rs7599312 1.000 rs7599312 chr2:213413231 C/T cg16329650 chr2:213403929 ERBB4 0.64 9.01 0.44 1.6e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg02428538 chr16:24856791 SLC5A11 0.5 5.76 0.3 1.88e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg03354898 chr7:1950403 MAD1L1 -0.43 -8.67 -0.43 1.93e-16 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.908 rs11098527 chr4:120399906 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.47 0.33 3.46e-10 Corneal astigmatism; LUSC cis rs478304 0.637 rs11227255 chr11:65454044 C/T cg27068330 chr11:65405492 SIPA1 -0.74 -10.3 -0.49 8.46e-22 Acne (severe); LUSC cis rs35079168 0.701 rs3132296 chr9:137302631 C/T cg14344989 chr9:137329237 RXRA -0.37 -6.05 -0.31 3.9e-9 Intelligence; LUSC trans rs34421088 0.532 rs2736388 chr8:11159588 T/C cg06636001 chr8:8085503 FLJ10661 0.44 6.36 0.33 6.71e-10 Neuroticism; LUSC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.88 -0.81 4.68e-78 Height; LUSC cis rs7089973 0.668 rs7077148 chr10:116644896 A/G cg23260525 chr10:116636907 FAM160B1 0.4 7.92 0.4 3.51e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg12463550 chr7:65579703 CRCP 0.53 7.66 0.39 2e-13 Aortic root size; LUSC cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg12310025 chr6:25882481 NA -0.35 -5.75 -0.3 1.99e-8 Height; LUSC trans rs12310956 0.532 rs11052922 chr12:33957476 A/G cg13010199 chr12:38710504 ALG10B 0.49 7.53 0.38 4.89e-13 Morning vs. evening chronotype; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg26406571 chr11:2422425 TSSC4 0.61 6.13 0.32 2.51e-9 Body mass index; LUSC cis rs4631830 0.863 rs2611508 chr10:51518047 T/A cg16070123 chr10:51489643 NA -0.51 -8.05 -0.4 1.47e-14 Prostate-specific antigen levels; LUSC cis rs7772486 0.875 rs9390371 chr6:146363180 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.15 -0.36 5.35e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7264396 0.887 rs224343 chr20:34036699 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.51 -0.34 2.74e-10 Total cholesterol levels; LUSC cis rs1595825 0.891 rs1992313 chr2:198896766 T/C cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs7246657 0.943 rs10413602 chr19:37891492 T/C cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs2302729 0.860 rs6489375 chr12:2777768 A/G cg19945202 chr12:2788847 CACNA1C -0.37 -5.65 -0.3 3.35e-8 Sleep quality; LUSC trans rs11098499 0.954 rs1480931 chr4:120395809 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.92 0.61 4.72e-35 Alzheimer's disease; LUSC cis rs6714788 0.565 rs7599083 chr2:100658077 G/A cg22139774 chr2:100720529 AFF3 -0.38 -6.04 -0.31 4.17e-9 Intelligence (multi-trait analysis); LUSC cis rs9517320 0.534 rs9554477 chr13:99160379 C/T cg07423050 chr13:99094983 FARP1 -0.48 -9.04 -0.44 1.32e-17 Longevity; LUSC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg04315214 chr1:2043799 PRKCZ 0.44 8.97 0.44 2.24e-17 Height; LUSC trans rs7937682 0.632 rs11214015 chr11:111719417 A/T cg18187862 chr3:45730750 SACM1L 0.54 6.47 0.33 3.5e-10 Primary sclerosing cholangitis; LUSC cis rs8072100 0.720 rs4794057 chr17:45786452 C/T cg19784903 chr17:45786737 TBKBP1 -0.42 -6.56 -0.34 2.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs11098499 0.730 rs12505735 chr4:120532956 G/T cg25214090 chr10:38739885 LOC399744 0.46 6.88 0.35 3.03e-11 Corneal astigmatism; LUSC cis rs7712401 0.562 rs30046 chr5:122271233 G/C cg19077854 chr5:122220652 SNX24 0.41 8.98 0.44 1.95e-17 Mean platelet volume; LUSC cis rs2439831 0.867 rs16957632 chr15:43642897 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs11030122 0.673 rs10767767 chr11:4003678 C/T cg18678763 chr11:4115507 RRM1 -0.44 -5.91 -0.31 8.37e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg05738196 chr6:26577821 NA 0.79 15.24 0.64 3.63e-40 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.9 0.51 6.96e-24 Monocyte percentage of white cells; LUSC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg17971929 chr21:40555470 PSMG1 0.49 7.4 0.38 1.13e-12 Menarche (age at onset); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg00934312 chr7:149570931 ATP6V0E2;LOC401431 -0.4 -6.02 -0.31 4.56e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11785400 1.000 rs3735999 chr8:143746069 T/C cg10596483 chr8:143751796 JRK 0.61 9.52 0.46 3.68e-19 Schizophrenia; LUSC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg18681998 chr4:17616180 MED28 0.9 17.87 0.7 1.39e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg04362960 chr10:104952993 NT5C2 0.52 6.56 0.34 2.07e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10779751 1.000 rs4845856 chr1:11274547 T/C cg08854313 chr1:11322531 MTOR 0.91 16.0 0.66 3.48e-43 Body mass index; LUSC cis rs1538970 1.000 rs4660852 chr1:45848931 A/C cg05343316 chr1:45956843 TESK2 -0.57 -8.27 -0.41 3.3e-15 Platelet count; LUSC cis rs11031096 0.738 rs9937 chr11:4159457 A/G cg18678763 chr11:4115507 RRM1 0.39 5.78 0.3 1.7e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg24675658 chr1:53192096 ZYG11B -0.67 -10.66 -0.5 4.97e-23 Monocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14783567 chr1:244211067 NA -0.38 -6.26 -0.32 1.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10761482 0.861 rs1350633 chr10:62111910 T/C cg18175470 chr10:62150864 ANK3 -0.51 -7.25 -0.37 2.99e-12 Schizophrenia; LUSC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg09796270 chr17:17721594 SREBF1 0.44 7.94 0.4 3.14e-14 Total body bone mineral density; LUSC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg02534363 chr3:47050950 NBEAL2 0.37 6.01 0.31 4.78e-9 Colorectal cancer; LUSC trans rs7618501 0.571 rs2240329 chr3:50107512 G/A cg21659725 chr3:3221576 CRBN -0.64 -10.64 -0.5 5.73e-23 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.779 rs7674500 chr4:120303593 C/T cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs11229555 0.645 rs11229445 chr11:58199458 G/A cg15696309 chr11:58395628 NA -0.6 -7.42 -0.38 9.52e-13 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs11997175 0.545 rs5005657 chr8:33668913 C/G ch.8.33884649F chr8:33765107 NA 0.5 7.17 0.37 4.86e-12 Body mass index; LUSC trans rs4689592 0.587 rs6825954 chr4:7074226 T/C cg07817883 chr1:32538562 TMEM39B -0.58 -6.73 -0.35 7.27e-11 Monocyte percentage of white cells; LUSC cis rs11785693 0.862 rs62491169 chr8:4986425 C/A cg26367366 chr8:4980734 NA 0.79 9.34 0.46 1.4e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs4654899 1.000 rs12133780 chr1:21270808 G/A cg01072550 chr1:21505969 NA -0.54 -8.13 -0.41 8.21e-15 Superior frontal gyrus grey matter volume; LUSC cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.56 -0.34 2.03e-10 Menarche (age at onset); LUSC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg05855489 chr10:104503620 C10orf26 0.59 9.53 0.46 3.31e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.91 0.4 3.73e-14 Prudent dietary pattern; LUSC cis rs5758511 0.514 rs2899354 chr22:42554409 G/T cg00645731 chr22:42541494 CYP2D7P1 0.6 10.18 0.49 2.17e-21 Birth weight; LUSC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg02269571 chr22:50332266 NA 0.58 8.61 0.43 2.88e-16 Schizophrenia; LUSC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25369027 chr8:103666178 KLF10 0.45 6.38 0.33 5.81e-10 Mosquito bite size; LUSC cis rs75804782 0.581 rs72987336 chr2:239365345 T/C cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.36e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs950776 0.518 rs12914694 chr15:78814444 G/A cg22563815 chr15:78856949 CHRNA5 0.27 6.39 0.33 5.69e-10 Sudden cardiac arrest; LUSC cis rs6545883 0.525 rs1729658 chr2:61373520 C/T cg15711740 chr2:61764176 XPO1 -0.38 -6.17 -0.32 1.96e-9 Tuberculosis; LUSC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg07395648 chr5:131743802 NA 0.43 7.08 0.36 8.43e-12 Blood metabolite levels; LUSC trans rs6502050 0.835 rs8077772 chr17:80117220 A/G cg07393940 chr7:158741817 NA -0.38 -6.96 -0.36 1.86e-11 Life satisfaction; LUSC cis rs2742417 1.000 rs2742447 chr3:45763977 C/T cg09608765 chr3:45636137 LIMD1 -0.36 -7.06 -0.36 9.54e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9462027 0.628 rs10947532 chr6:34780315 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs7927771 0.524 rs10838782 chr11:47877800 A/G cg20307385 chr11:47447363 PSMC3 0.47 6.84 0.35 3.82e-11 Subjective well-being; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17107073 chr14:69951322 FLJ44817 0.41 5.97 0.31 5.94e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12893668 0.703 rs4906337 chr14:104040414 C/A cg08213375 chr14:104286397 PPP1R13B 0.38 6.24 0.32 1.29e-9 Reticulocyte count; LUSC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg04414720 chr1:150670196 GOLPH3L 0.54 8.46 0.42 8.59e-16 Melanoma; LUSC cis rs4664304 0.966 rs925411 chr2:160745785 G/T cg03641300 chr2:160917029 PLA2R1 -0.39 -6.31 -0.33 8.83e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01524091 chr6:44281032 AARS2 -0.5 -6.67 -0.34 1.08e-10 Bipolar disorder and schizophrenia; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg00149659 chr3:10157352 C3orf10 0.92 11.72 0.54 8.44e-27 Alzheimer's disease; LUSC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg08683831 chr4:1404607 NA 0.35 5.94 0.31 7.03e-9 Obesity-related traits; LUSC cis rs9660992 0.626 rs1172113 chr1:205226288 T/C cg21545522 chr1:205238299 TMCC2 0.48 9.07 0.44 1.07e-17 Mean corpuscular volume;Mean platelet volume; LUSC trans rs61931739 0.500 rs11053177 chr12:34412829 G/A cg13010199 chr12:38710504 ALG10B 0.58 9.23 0.45 3.24e-18 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.2 0.52 6.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9309473 0.519 rs6746971 chr2:73669462 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -7.17 -0.37 4.93e-12 Metabolite levels; LUSC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.58 9.09 0.45 8.88e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11992162 0.613 rs56094399 chr8:11797470 G/A cg15556689 chr8:8085844 FLJ10661 -0.51 -7.29 -0.37 2.26e-12 Monocyte count; LUSC cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg13609457 chr4:120235615 NA -0.41 -5.8 -0.3 1.51e-8 Corneal astigmatism; LUSC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.08 0.36 8.35e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs6502050 0.835 rs7501527 chr17:80099355 A/C cg07393940 chr7:158741817 NA 0.37 6.6 0.34 1.62e-10 Life satisfaction; LUSC trans rs7613875 0.600 rs1061474 chr3:50144951 T/C cg21659725 chr3:3221576 CRBN -0.54 -8.45 -0.42 8.92e-16 Body mass index; LUSC cis rs7572644 0.640 rs4632296 chr2:28024984 T/C cg27432699 chr2:27873401 GPN1 0.56 7.3 0.37 2.09e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg25072359 chr17:41440525 NA 0.68 9.58 0.46 2.24e-19 Menopause (age at onset); LUSC cis rs3806843 0.966 rs2563263 chr5:140137644 A/G cg19875535 chr5:140030758 IK 0.48 7.13 0.36 6.16e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs73416724 1.000 rs111467122 chr6:43334547 C/T cg26312998 chr6:43337775 ZNF318 0.57 6.62 0.34 1.4e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2624839 0.704 rs1046956 chr3:50222926 T/A cg24110177 chr3:50126178 RBM5 0.51 8.08 0.4 1.23e-14 Intelligence (multi-trait analysis); LUSC cis rs1215050 0.791 rs1669745 chr4:98842047 G/A cg05340658 chr4:99064831 C4orf37 -0.43 -6.86 -0.35 3.3e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs240764 0.817 rs12214151 chr6:101159516 G/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.12 -0.32 2.61e-9 Neuroticism; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 13.18 0.58 3.15e-32 Alzheimer's disease; LUSC cis rs11123610 0.679 rs34705357 chr2:3716032 C/T cg25251562 chr2:3704773 ALLC -0.42 -6.85 -0.35 3.53e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg13531842 chr10:38383804 ZNF37A -0.44 -6.85 -0.35 3.62e-11 Extrinsic epigenetic age acceleration; LUSC cis rs11971779 0.793 rs9632774 chr7:139137562 C/T cg07862535 chr7:139043722 LUC7L2 0.51 6.33 0.33 7.85e-10 Diisocyanate-induced asthma; LUSC cis rs3813567 0.759 rs7163204 chr15:78953740 G/A cg24631222 chr15:78858424 CHRNA5 0.54 6.11 0.32 2.73e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg04369109 chr6:150039330 LATS1 -0.56 -8.29 -0.41 2.88e-15 Lung cancer; LUSC cis rs11031096 0.683 rs10835729 chr11:4210847 T/C cg18678763 chr11:4115507 RRM1 -0.41 -5.71 -0.3 2.5e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg00677455 chr12:58241039 CTDSP2 0.59 8.36 0.42 1.67e-15 Multiple sclerosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16483426 chr12:110151678 C12orf34 -0.42 -6.26 -0.32 1.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs71537559 1 rs71537559 chr6:27309779 G/C cg01620082 chr3:125678407 NA -0.76 -6.83 -0.35 3.98e-11 Squamous cell lung carcinoma; LUSC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg16339924 chr4:17578868 LAP3 0.62 9.4 0.46 9.06e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs77633900 0.614 rs2469244 chr15:76884127 G/A cg21673338 chr15:77095150 SCAPER -0.72 -6.99 -0.36 1.48e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.81 0.35 4.44e-11 Rheumatoid arthritis; LUSC cis rs7215564 0.908 rs34384177 chr17:78667040 A/T cg23238734 chr17:78661607 RPTOR 0.49 6.43 0.33 4.46e-10 Myopia (pathological); LUSC cis rs11758351 0.660 rs11759904 chr6:26231443 T/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs4622329 0.615 rs7954630 chr12:102290154 G/A cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC trans rs7647973 0.626 rs1078341 chr3:49685592 A/G cg21659725 chr3:3221576 CRBN -0.66 -7.99 -0.4 2.22e-14 Menarche (age at onset); LUSC cis rs6750047 0.868 rs1431332 chr2:38280253 G/A cg07380506 chr2:38303506 CYP1B1 0.49 6.87 0.35 3.12e-11 Cutaneous malignant melanoma;Melanoma; LUSC cis rs67311347 0.955 rs2123999 chr3:40378738 C/T cg02782426 chr3:40428986 ENTPD3 0.33 6.46 0.33 3.78e-10 Renal cell carcinoma; LUSC cis rs1577917 0.876 rs1582127 chr6:86697204 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.21 -0.41 4.76e-15 Response to antipsychotic treatment; LUSC cis rs11711311 0.911 rs34337798 chr3:113396704 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 5.93 0.31 7.38e-9 IgG glycosylation; LUSC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg16339924 chr4:17578868 LAP3 0.59 9.02 0.44 1.47e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 10.96 0.51 4.44e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs67072384 1.000 rs7125722 chr11:72449716 G/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.4e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs6733011 0.500 rs6755640 chr2:99445917 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -5.86 -0.31 1.14e-8 Bipolar disorder; LUSC cis rs1691799 0.899 rs1177555 chr12:66727568 A/G cg16791601 chr12:66731901 HELB -0.71 -12.39 -0.56 2.81e-29 White blood cell count (basophil); LUSC cis rs3806843 0.576 rs246030 chr5:140333154 C/G cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg20887711 chr4:1340912 KIAA1530 0.71 11.91 0.55 1.64e-27 Longevity; LUSC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg04352962 chr1:209979756 IRF6 0.55 6.46 0.33 3.73e-10 Cleft lip with or without cleft palate; LUSC cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg07424592 chr7:64974309 NA -0.66 -5.72 -0.3 2.42e-8 Diabetic kidney disease; LUSC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.62 -0.6 6.89e-34 Intelligence (multi-trait analysis); LUSC trans rs9467711 0.659 rs72844462 chr6:26563864 A/C cg06606381 chr12:133084897 FBRSL1 -0.74 -6.52 -0.34 2.64e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg06238570 chr21:40685208 BRWD1 -0.53 -8.16 -0.41 6.74e-15 Menarche (age at onset); LUSC cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg13256891 chr4:100009986 ADH5 0.51 6.96 0.36 1.79e-11 Smoking initiation; LUSC cis rs7216064 0.700 rs4791295 chr17:65997317 G/A cg12091567 chr17:66097778 LOC651250 -0.82 -10.95 -0.51 4.64e-24 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg21518248 chr2:162101506 NA 0.45 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs847577 0.630 rs11764933 chr7:97825188 G/A cg24562669 chr7:97807699 LMTK2 0.48 8.56 0.42 4.18e-16 Breast cancer; LUSC cis rs2637266 1.000 rs2395387 chr10:78357029 T/C cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs2486288 0.656 rs8041702 chr15:45547093 C/T cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.8 -0.39 7.77e-14 Glomerular filtration rate; LUSC cis rs3803170 0.513 rs11065888 chr12:111828663 G/C cg10833066 chr12:111807467 FAM109A 0.39 7.24 0.37 3.19e-12 Mean corpuscular hemoglobin; LUSC cis rs4144743 1.000 rs4541130 chr17:45321037 G/A cg18085866 chr17:45331354 ITGB3 -0.8 -8.43 -0.42 1.05e-15 Body mass index; LUSC cis rs2143950 0.512 rs77772792 chr14:35520127 C/G cg16230307 chr14:35515116 FAM177A1 -0.43 -5.83 -0.3 1.31e-8 Atopic dermatitis; LUSC cis rs1371867 0.846 rs1660317 chr8:101333252 G/T cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs686320 1.000 rs616599 chr11:65254025 T/G cg21890820 chr11:65308645 LTBP3 0.8 7.81 0.39 7.38e-14 Hip circumference adjusted for BMI; LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg20887711 chr4:1340912 KIAA1530 0.45 6.68 0.34 9.71e-11 Obesity-related traits; LUSC cis rs7771547 0.573 rs10440841 chr6:36399086 G/A cg07856975 chr6:36356162 ETV7 -0.35 -6.3 -0.33 9.53e-10 Platelet distribution width; LUSC cis rs34779708 0.966 rs6481941 chr10:35440141 G/A cg03585969 chr10:35415529 CREM 0.59 8.8 0.43 7.47e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1113500 0.509 rs17020915 chr1:108647006 G/T cg11967332 chr1:108735228 SLC25A24 0.42 5.73 0.3 2.22e-8 Growth-regulated protein alpha levels; LUSC trans rs1908814 0.516 rs58869268 chr8:11797095 G/C cg27411982 chr8:10470053 RP1L1 0.41 6.32 0.33 8.43e-10 Neuroticism; LUSC cis rs9372253 0.818 rs2207360 chr6:110706337 G/C cg19196401 chr6:110721138 DDO -0.46 -8.73 -0.43 1.28e-16 Platelet distribution width; LUSC cis rs7577851 0.953 rs6760776 chr2:69738790 T/C cg10773587 chr2:69614142 GFPT1 0.47 5.73 0.3 2.3e-8 Parkinson's disease (age of onset); LUSC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 7.9 0.4 4.16e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.47 -0.56 1.51e-29 Alzheimer's disease; LUSC cis rs9322817 0.540 rs2034823 chr6:105219573 A/T cg02098413 chr6:105308735 HACE1 -0.28 -5.7 -0.3 2.59e-8 Thyroid stimulating hormone; LUSC cis rs1003719 0.680 rs767998 chr21:38525652 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.54 -0.5 1.26e-22 Eye color traits; LUSC trans rs6582630 0.502 rs11520234 chr12:38255005 G/A cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs12510870 0.511 rs3822100 chr4:74309472 C/G cg01940055 chr4:146018582 ANAPC10;ABCE1 0.37 6.07 0.32 3.38e-9 Iris color (b* coordinate); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03571684 chr8:94753266 RBM12B -0.41 -6.05 -0.31 3.94e-9 Electrocardiographic conduction measures; LUSC cis rs7617480 0.616 rs7429596 chr3:48808531 T/C cg21141812 chr3:48556323 PFKFB4 0.33 5.69 0.3 2.72e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7605827 0.930 rs13410044 chr2:15602535 A/G cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg18131467 chr2:239335373 ASB1 1.06 25.42 0.81 4.43e-80 Multiple system atrophy; LUSC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg25072359 chr17:41440525 NA 0.58 8.33 0.41 2.14e-15 Menopause (age at onset); LUSC cis rs478304 0.934 rs603645 chr11:65533000 A/C cg27068330 chr11:65405492 SIPA1 0.62 9.33 0.45 1.54e-18 Acne (severe); LUSC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg00784671 chr22:46762841 CELSR1 -0.54 -6.79 -0.35 5.18e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg18404041 chr3:52824283 ITIH1 -0.57 -9.59 -0.46 2.19e-19 Schizophrenia; LUSC cis rs1953600 0.668 rs751740 chr10:81912179 T/C cg00277334 chr10:82204260 NA 0.41 6.32 0.33 8.29e-10 Sarcoidosis; LUSC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg24562669 chr7:97807699 LMTK2 0.34 5.98 0.31 5.9e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg11764359 chr7:65958608 NA -0.49 -7.24 -0.37 3.11e-12 Calcium levels; LUSC cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg15744005 chr10:104629667 AS3MT -0.34 -6.89 -0.35 2.75e-11 Arsenic metabolism; LUSC cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg15395560 chr15:45543142 SLC28A2 0.33 5.66 0.3 3.25e-8 Uric acid levels; LUSC cis rs9928842 0.882 rs6564241 chr16:75263974 T/C cg09066997 chr16:75300724 BCAR1 0.54 6.37 0.33 6.12e-10 Alcoholic chronic pancreatitis; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg27094323 chr7:1216898 NA -0.38 -6.56 -0.34 2.1e-10 Longevity;Endometriosis; LUSC cis rs9303280 0.806 rs4795395 chr17:37962987 T/A cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.69 0.3 2.81e-8 Self-reported allergy; LUSC cis rs80130819 0.748 rs7953726 chr12:48611757 A/G cg24011408 chr12:48396354 COL2A1 0.47 5.88 0.31 1.01e-8 Prostate cancer; LUSC cis rs1595825 0.732 rs114972685 chr2:198437829 G/A cg00982548 chr2:198649783 BOLL -0.51 -6.23 -0.32 1.36e-9 Ulcerative colitis; LUSC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg13206674 chr6:150067644 NUP43 -0.6 -9.74 -0.47 6.86e-20 Lung cancer; LUSC cis rs4654899 0.758 rs6426665 chr1:21382205 T/C cg01072550 chr1:21505969 NA -0.51 -7.82 -0.39 6.9e-14 Superior frontal gyrus grey matter volume; LUSC trans rs6502050 0.835 rs62078304 chr17:80085224 G/A cg07393940 chr7:158741817 NA -0.38 -6.83 -0.35 4.05e-11 Life satisfaction; LUSC cis rs2859741 1.000 rs543121 chr1:37497098 T/C cg09363841 chr1:37513479 NA -0.38 -7.43 -0.38 9.26e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs988712 0.672 rs16917237 chr11:27702383 A/C cg10635145 chr11:27742435 BDNF 0.44 5.79 0.3 1.62e-8 Obesity; LUSC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.27 0.56 8.02e-29 Cognitive test performance; LUSC cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.71 -9.46 -0.46 5.81e-19 Chronic sinus infection; LUSC cis rs2294693 0.945 rs932399 chr6:41011266 C/T cg14769373 chr6:40998127 UNC5CL -0.57 -7.33 -0.37 1.76e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs2617583 0.509 rs13089 chr5:1462732 G/C cg13982541 chr5:1466431 LPCAT1 0.41 5.85 0.3 1.18e-8 Breast cancer; LUSC trans rs12883384 1.000 rs2416009 chr14:47405018 A/T cg09323092 chr16:921072 LMF1 0.32 6.06 0.31 3.76e-9 Neuroticism; LUSC cis rs7100689 0.577 rs1340385 chr10:82058851 G/A cg01528321 chr10:82214614 TSPAN14 0.9 13.31 0.59 1.02e-32 Post bronchodilator FEV1; LUSC cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg18132916 chr6:79620363 NA -0.38 -5.69 -0.3 2.82e-8 Intelligence (multi-trait analysis); LUSC cis rs4988958 0.565 rs1035125 chr2:103033839 C/A cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma (childhood onset); LUSC cis rs4664308 0.935 rs4520993 chr2:160937673 G/A cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg09267113 chr7:98030324 BAIAP2L1 0.4 5.96 0.31 6.59e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.01 0.55 7.43e-28 Colorectal cancer; LUSC cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg12219531 chr12:120966889 COQ5 0.62 8.31 0.41 2.42e-15 High light scatter reticulocyte count; LUSC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg23625390 chr15:77176239 SCAPER 0.43 6.37 0.33 6.44e-10 Blood metabolite levels; LUSC trans rs2243480 1.000 rs35396113 chr7:65495461 C/T cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.57e-15 Diabetic kidney disease; LUSC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs7208859 0.673 rs9895815 chr17:29138033 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9329221 0.527 rs4841351 chr8:10327367 G/A cg27411982 chr8:10470053 RP1L1 -0.45 -6.9 -0.35 2.61e-11 Neuroticism; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10894697 chr10:115439008 CASP7 -0.48 -7.02 -0.36 1.26e-11 Electrocardiographic conduction measures; LUSC cis rs12912251 0.947 rs7171233 chr15:38988760 T/A cg01338139 chr15:38987640 C15orf53 -0.5 -6.83 -0.35 3.95e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs9467711 0.606 rs9366653 chr6:26354247 G/A cg14345882 chr6:26364793 BTN3A2 0.6 5.69 0.3 2.81e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27067419 chr5:54830434 PPAP2A;RNF138P1 -0.5 -6.2 -0.32 1.64e-9 Bipolar disorder and schizophrenia; LUSC cis rs4786125 0.665 rs1565633 chr16:6919428 G/C cg03623568 chr16:6915990 A2BP1 -0.5 -8.39 -0.42 1.38e-15 Heart rate variability traits (SDNN); LUSC cis rs7605827 0.930 rs1996517 chr2:15517330 T/C cg19274914 chr2:15703543 NA 0.45 8.73 0.43 1.27e-16 Educational attainment (years of education); LUSC cis rs9467773 0.595 rs9366657 chr6:26434914 C/G cg05738196 chr6:26577821 NA 0.54 8.13 0.41 8.44e-15 Intelligence (multi-trait analysis); LUSC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg00343127 chr12:129299088 SLC15A4;MGC16384 0.35 5.68 0.3 2.99e-8 Systemic lupus erythematosus; LUSC cis rs2718798 1 rs2718798 chr3:133492088 A/C cg01448562 chr3:133502909 NA -0.53 -8.3 -0.41 2.67e-15 Ankle injury; LUSC cis rs2692947 0.550 rs12623771 chr2:96633504 A/G cg23100626 chr2:96804247 ASTL 0.23 5.74 0.3 2.1e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7523273 0.853 rs7537216 chr1:208006429 A/T cg22525895 chr1:207977042 MIR29B2 -0.38 -5.66 -0.3 3.33e-8 Schizophrenia; LUSC cis rs2404602 0.740 rs34924128 chr15:76965169 T/G cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.23e-12 Blood metabolite levels; LUSC cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg19628046 chr18:33552617 C18orf21 0.51 5.96 0.31 6.29e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg00945038 chr17:61921165 SMARCD2 0.54 9.64 0.47 1.4e-19 Prudent dietary pattern; LUSC cis rs7829975 0.774 rs35431455 chr8:8673736 T/C cg15556689 chr8:8085844 FLJ10661 0.68 10.78 0.51 1.9e-23 Mood instability; LUSC cis rs6960043 0.818 rs6967891 chr7:15065074 T/C cg19272540 chr7:15055459 NA -0.31 -7.66 -0.39 2.02e-13 Type 2 diabetes; LUSC trans rs7618501 0.633 rs11130234 chr3:50024758 G/T cg21659725 chr3:3221576 CRBN 0.62 10.21 0.49 1.78e-21 Intelligence (multi-trait analysis); LUSC cis rs394563 0.589 rs1900300 chr6:149641627 T/C cg03678062 chr6:149772716 ZC3H12D 0.3 6.03 0.31 4.38e-9 Dupuytren's disease; LUSC cis rs1728785 1.000 rs1645981 chr16:68571648 T/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg00071950 chr4:10020882 SLC2A9 -0.54 -8.36 -0.42 1.77e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10876993 1.000 rs10876993 chr12:58062667 C/T cg18357645 chr12:58087776 OS9 0.56 8.58 0.43 3.53e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg25124228 chr12:125621409 AACS 0.45 6.9 0.35 2.67e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -10.1 -0.48 4.1e-21 Autism spectrum disorder or schizophrenia; LUSC cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg06552810 chr11:31128660 NA -0.4 -6.95 -0.36 1.93e-11 Red blood cell count; LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg26659404 chr1:25747437 RHCE -0.28 -5.86 -0.31 1.08e-8 Erythrocyte sedimentation rate; LUSC cis rs9902453 0.740 rs2617884 chr17:28120430 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.67 -0.54 1.26e-26 Coffee consumption (cups per day); LUSC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg14500267 chr11:67383377 NA 0.3 5.68 0.3 2.91e-8 Mean corpuscular volume; LUSC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg05234568 chr11:5960015 NA -0.58 -8.28 -0.41 3.1e-15 DNA methylation (variation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16326979 chr8:107670161 OXR1 -0.39 -5.97 -0.31 6.23e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg18135555 chr8:22132992 PIWIL2 0.39 7.82 0.39 7.14e-14 Hypertriglyceridemia; LUSC cis rs2677744 0.688 rs2239293 chr15:91450350 G/A cg23684204 chr15:91497937 RCCD1 0.43 5.94 0.31 7e-9 Attention deficit hyperactivity disorder; LUSC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.37 0.62 8.94e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8133932 0.654 rs375971 chr21:47338854 C/G cg14185626 chr21:47401492 COL6A1 -0.46 -5.88 -0.31 1.01e-8 Schizophrenia; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg00149659 chr3:10157352 C3orf10 -1.16 -15.15 -0.64 8.09e-40 Alzheimer's disease; LUSC cis rs11971779 0.680 rs11980313 chr7:139034643 C/G cg07862535 chr7:139043722 LUC7L2 0.54 6.75 0.35 6.59e-11 Diisocyanate-induced asthma; LUSC cis rs79149102 0.579 rs61166993 chr15:75306644 C/A cg09165964 chr15:75287851 SCAMP5 -0.91 -8.56 -0.42 4.25e-16 Lung cancer; LUSC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg09998033 chr7:158218633 PTPRN2 -0.59 -9.64 -0.47 1.4e-19 Obesity-related traits; LUSC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1957429 0.520 rs230723 chr14:65316017 C/T cg23373153 chr14:65346875 NA -0.83 -7.65 -0.39 2.18e-13 Pediatric areal bone mineral density (radius); LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs950169 0.650 rs12902052 chr15:85125838 A/T cg17173187 chr15:85201210 NMB 0.38 6.65 0.34 1.21e-10 Schizophrenia; LUSC cis rs7577696 0.924 rs212760 chr2:32429222 A/G cg02381751 chr2:32503542 YIPF4 0.4 5.79 0.3 1.6e-8 Inflammatory biomarkers; LUSC cis rs12200782 1.000 rs12205909 chr6:26630999 G/A cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg20607798 chr8:58055168 NA 0.57 5.78 0.3 1.7e-8 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg11663144 chr21:46675770 NA -0.33 -5.74 -0.3 2.15e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.96e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13215566 0.929 rs35007480 chr6:89924201 A/G cg08400210 chr6:89908154 GABRR1 0.46 5.88 0.31 9.95e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg02187348 chr16:89574699 SPG7 0.5 7.77 0.39 9.65e-14 Multiple myeloma (IgH translocation); LUSC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.79 0.57 9.23e-31 Hip circumference adjusted for BMI; LUSC cis rs4363385 0.510 rs7541328 chr1:152894142 C/G cg00922841 chr1:152955080 SPRR1A -0.36 -5.88 -0.31 1.02e-8 Inflammatory skin disease; LUSC cis rs3008870 1.000 rs3008894 chr1:67377739 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.93 14.4 0.62 6.68e-37 Lymphocyte percentage of white cells; LUSC cis rs7582180 0.614 rs4340543 chr2:101005511 G/A cg08017756 chr2:100939284 LONRF2 -0.43 -8.09 -0.4 1.13e-14 Intelligence (multi-trait analysis); LUSC cis rs9325144 0.600 rs61931871 chr12:38829889 G/A cg13010199 chr12:38710504 ALG10B -0.49 -7.45 -0.38 7.87e-13 Morning vs. evening chronotype; LUSC cis rs3820928 0.845 rs13384342 chr2:227805010 G/A cg11843606 chr2:227700838 RHBDD1 -0.55 -8.03 -0.4 1.67e-14 Pulmonary function; LUSC cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg08999081 chr20:33150536 PIGU 0.55 10.87 0.51 9.32e-24 Coronary artery disease; LUSC cis rs2559856 1.000 rs2695284 chr12:102089318 A/G cg12924262 chr12:102091054 CHPT1 -0.42 -6.03 -0.31 4.34e-9 Blood protein levels; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg20607798 chr8:58055168 NA 0.54 5.82 0.3 1.39e-8 Developmental language disorder (linguistic errors); LUSC cis rs7640424 0.620 rs17231503 chr3:107817299 C/T cg09227934 chr3:107805635 CD47 -0.53 -7.64 -0.39 2.29e-13 Body mass index; LUSC cis rs8017423 0.967 rs12896540 chr14:90729392 T/C cg04374321 chr14:90722782 PSMC1 -0.7 -10.51 -0.5 1.66e-22 Mortality in heart failure; LUSC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg11812906 chr14:75593930 NEK9 0.63 10.55 0.5 1.22e-22 Height; LUSC trans rs12145833 0.538 rs12026408 chr1:243366805 G/A cg25284624 chr1:224180302 NA 0.7 6.63 0.34 1.36e-10 Obesity (early onset extreme); LUSC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg13939156 chr17:80058883 NA 0.34 6.55 0.34 2.14e-10 Life satisfaction; LUSC cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.06 0.55 4.63e-28 Colorectal cancer; LUSC cis rs778371 0.723 rs11689851 chr2:233567342 A/G cg08000102 chr2:233561755 GIGYF2 0.82 12.92 0.58 2.93e-31 Schizophrenia; LUSC cis rs7524258 0.903 rs4908608 chr1:7292772 T/C cg07173049 chr1:7289937 CAMTA1 0.37 7.69 0.39 1.62e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs561341 0.739 rs7213369 chr17:30211878 G/A cg00745463 chr17:30367425 LRRC37B 0.57 7.26 0.37 2.74e-12 Hip circumference adjusted for BMI; LUSC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.68 0.39 1.73e-13 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9300255 0.537 rs1618679 chr12:123650714 A/G cg05973401 chr12:123451056 ABCB9 0.54 6.67 0.34 1.06e-10 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1712517 0.524 rs1712509 chr10:105013870 G/T cg04362960 chr10:104952993 NT5C2 -0.53 -7.12 -0.36 6.77e-12 Migraine; LUSC cis rs12586317 0.548 rs12590678 chr14:35602956 C/T cg16230307 chr14:35515116 FAM177A1 0.7 9.19 0.45 4.4e-18 Psoriasis; LUSC cis rs10791323 0.569 rs2156679 chr11:133742304 C/T cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC cis rs7819412 0.740 rs11250119 chr8:11037034 C/T cg21775007 chr8:11205619 TDH -0.48 -6.95 -0.36 1.94e-11 Triglycerides; LUSC trans rs10096351 0.574 rs684254 chr8:128338693 G/A cg10195415 chr17:73887371 TRIM65 0.41 6.64 0.34 1.3100000000000001e-10 Breast cancer; LUSC cis rs11229555 0.645 rs4594017 chr11:58194788 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs3771570 0.901 rs62190413 chr2:242417950 G/A cg21155796 chr2:242212141 HDLBP 0.61 6.86 0.35 3.35e-11 Prostate cancer; LUSC cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.84 -0.44 5.49e-17 Monocyte percentage of white cells; LUSC cis rs11642862 1.000 rs75500538 chr16:30782449 G/A cg02466173 chr16:30829666 NA -0.71 -7.59 -0.38 3.31e-13 Tonsillectomy; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg12379764 chr21:47803548 PCNT -0.5 -7.15 -0.36 5.39e-12 Testicular germ cell tumor; LUSC cis rs7804356 0.859 rs2391362 chr7:26907123 T/C cg03456212 chr7:26904342 SKAP2 -0.57 -6.51 -0.34 2.76e-10 Type 1 diabetes; LUSC cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.4 -0.46 8.69e-19 Schizophrenia; LUSC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg22467129 chr15:76604101 ETFA -0.44 -6.86 -0.35 3.27e-11 Blood metabolite levels; LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg08088566 chr11:430123 ANO9 0.62 7.2 0.37 3.89e-12 Body mass index; LUSC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg21699342 chr2:239360505 ASB1 0.56 10.3 0.49 8.39e-22 Multiple system atrophy; LUSC trans rs2797160 0.651 rs1268092 chr6:126029043 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.63 -10.02 -0.48 8.04e-21 Endometrial cancer; LUSC cis rs738322 0.810 rs4820325 chr22:38599978 G/A cg17652424 chr22:38574118 PLA2G6 0.28 5.69 0.3 2.79e-8 Cutaneous nevi; LUSC cis rs9359856 0.510 rs6937244 chr6:90468465 C/A cg13799429 chr6:90582589 CASP8AP2 0.91 10.87 0.51 8.88e-24 Bipolar disorder; LUSC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.99 0.31 5.57e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.69 0.47 1.02e-19 Personality dimensions; LUSC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg09021430 chr5:549028 NA -0.55 -7.57 -0.38 3.64e-13 Obesity-related traits; LUSC cis rs1448094 0.967 rs7961782 chr12:86326461 T/C cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.31e-9 Major depressive disorder; LUSC cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg12379764 chr21:47803548 PCNT -0.43 -6.0 -0.31 5.12e-9 Testicular germ cell tumor; LUSC cis rs9815354 0.767 rs73830585 chr3:42003698 T/A cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg12311346 chr5:56204834 C5orf35 -0.61 -9.41 -0.46 8.33e-19 Coronary artery disease; LUSC cis rs7589342 0.536 rs10198057 chr2:106392799 A/C cg09152813 chr2:106391379 NCK2 0.39 6.35 0.33 7.16e-10 Addiction; LUSC trans rs13113518 0.812 rs12500601 chr4:56317656 T/C cg07140194 chr2:73150236 EMX1 0.6 6.1 0.32 2.9e-9 Height; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg19318889 chr4:1322082 MAEA 0.47 8.06 0.4 1.4e-14 Longevity; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19168507 chr11:107436485 ALKBH8 0.46 5.95 0.31 6.91e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg00321850 chr1:175162397 KIAA0040 0.46 7.83 0.39 6.5e-14 Alcohol dependence; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24048372 chr5:93954560 C5orf36;ANKRD32 -0.55 -6.85 -0.35 3.46e-11 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg07936489 chr17:37558343 FBXL20 0.72 10.24 0.49 1.43e-21 Glomerular filtration rate (creatinine); LUSC cis rs9467773 0.583 rs1021373 chr6:26632457 G/A cg09904177 chr6:26538194 HMGN4 0.65 11.7 0.54 9.83e-27 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.52 -0.42 5.64e-16 Chronic sinus infection; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05970768 chr5:171682616 UBTD2 0.55 6.73 0.35 7.42e-11 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg23601095 chr6:26197514 HIST1H3D 0.65 7.19 0.37 4.21e-12 Gout;Renal underexcretion gout; LUSC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg25072359 chr17:41440525 NA 0.6 8.66 0.43 2e-16 Menopause (age at onset); LUSC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg03806693 chr22:41940476 POLR3H -1.02 -14.65 -0.63 7.28e-38 Vitiligo; LUSC cis rs7824557 0.593 rs11774673 chr8:11191537 T/C cg21293242 chr8:11204541 TDH 0.32 6.06 0.31 3.65e-9 Retinal vascular caliber; LUSC trans rs12317459 0.591 rs11115437 chr12:83204590 G/A cg10237817 chr1:154519846 TDRD10 0.31 6.14 0.32 2.28e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg04369109 chr6:150039330 LATS1 -0.54 -7.97 -0.4 2.48e-14 Lung cancer; LUSC trans rs7786808 0.741 rs11765319 chr7:158226790 A/G cg02030672 chr11:45687055 CHST1 0.41 6.24 0.32 1.33e-9 Obesity-related traits; LUSC cis rs897080 0.552 rs1067405 chr2:44674861 T/C cg00619915 chr2:44497795 NA -0.46 -6.59 -0.34 1.66e-10 Height; LUSC cis rs796364 1.000 rs71424239 chr2:200725473 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -8.04 -0.4 1.56e-14 Schizophrenia; LUSC cis rs116095464 0.558 rs10068203 chr5:206618 C/T cg22857025 chr5:266934 NA -1.19 -13.96 -0.61 3.19e-35 Breast cancer; LUSC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg17971929 chr21:40555470 PSMG1 0.71 11.18 0.52 7.56e-25 Cognitive function; LUSC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg19824325 chr16:58548873 SETD6 0.94 9.13 0.45 6.5e-18 Schizophrenia; LUSC cis rs2979489 0.786 rs2979514 chr8:30399461 A/C cg26383811 chr8:30366931 RBPMS -0.51 -8.18 -0.41 6.19e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs3744061 0.557 rs4261577 chr17:74648566 T/C cg27546012 chr17:74684504 MXRA7 -0.38 -6.53 -0.34 2.52e-10 Retinal arteriolar caliber; LUSC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg07716408 chr11:68623521 NA -0.32 -6.29 -0.33 9.88e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs67311347 0.544 rs2123998 chr3:40359005 C/G cg13683864 chr3:40499215 RPL14 0.76 12.0 0.55 8.23e-28 Renal cell carcinoma; LUSC trans rs2288327 1.000 rs3731746 chr2:179430997 G/A cg14011486 chr1:26737247 LIN28 0.47 5.99 0.31 5.53e-9 Atrial fibrillation; LUSC trans rs7937682 0.855 rs539693 chr11:111477387 A/G cg18187862 chr3:45730750 SACM1L 0.52 6.78 0.35 5.56e-11 Primary sclerosing cholangitis; LUSC cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg01884057 chr2:25150051 NA 0.48 11.39 0.53 1.31e-25 Body mass index; LUSC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg03233332 chr7:66118400 NA -0.42 -6.09 -0.32 3.02e-9 Aortic root size; LUSC cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.65 0.43 2.21e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7568458 0.783 rs1561198 chr2:85809989 C/T cg23752985 chr2:85803571 VAMP8 0.34 7.45 0.38 8.02e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs12594515 1.000 rs12906442 chr15:45985254 C/A cg19682013 chr15:45996608 NA 0.39 5.82 0.3 1.41e-8 Waist circumference;Weight; LUSC cis rs427394 0.632 rs377137 chr5:6740468 T/G cg10857441 chr5:6722123 POLS -0.44 -8.08 -0.4 1.19e-14 Menopause (age at onset); LUSC cis rs7043114 0.525 rs7847929 chr9:95154244 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.63 -0.34 1.38e-10 Height; LUSC cis rs6087990 0.965 rs2424899 chr20:31343543 A/C cg13636640 chr20:31349939 DNMT3B 1.03 23.38 0.79 2.71e-72 Ulcerative colitis; LUSC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.46 6.09 0.32 3.14e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs12519773 0.597 rs4308464 chr5:92468867 G/C cg18783429 chr5:92414398 NA 0.34 7.42 0.38 9.81e-13 Migraine; LUSC cis rs765787 0.530 rs16941017 chr15:45543281 T/C cg25801113 chr15:45476975 SHF 0.33 6.81 0.35 4.54e-11 Uric acid levels; LUSC cis rs796364 0.616 rs1523818 chr2:200684704 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.99 0.31 5.55e-9 Schizophrenia; LUSC cis rs6121246 0.909 rs6058463 chr20:30385192 C/T cg13852791 chr20:30311386 BCL2L1 0.86 11.29 0.53 2.92e-25 Mean corpuscular hemoglobin; LUSC cis rs28530618 0.580 rs4607010 chr20:31255271 G/C cg13636640 chr20:31349939 DNMT3B -0.43 -5.75 -0.3 1.97e-8 Birth weight; LUSC cis rs748404 0.697 rs555001 chr15:43545728 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.8 0.39 8.14e-14 Lung cancer; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 12.66 0.57 2.89e-30 Platelet count; LUSC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg19920283 chr7:105172520 RINT1 0.58 6.12 0.32 2.65e-9 Bipolar disorder (body mass index interaction); LUSC cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -7.61 -0.38 2.91e-13 Chronic sinus infection; LUSC cis rs6785206 0.730 rs9861429 chr3:128425749 A/G cg16766828 chr3:128327626 NA -0.68 -7.5 -0.38 5.79e-13 Lymphocyte percentage of white cells; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg05368731 chr17:41323189 NBR1 0.94 15.86 0.66 1.24e-42 Menopause (age at onset); LUSC cis rs11676348 0.710 rs11894169 chr2:219046846 T/C cg23569941 chr2:219139048 TMBIM1;PNKD -0.37 -5.94 -0.31 7.31e-9 Ulcerative colitis; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg14893161 chr1:205819251 PM20D1 0.91 17.99 0.7 4.44e-51 Menarche (age at onset); LUSC cis rs13315871 1.000 rs71311855 chr3:58320507 A/G cg12435725 chr3:58293450 RPP14 -0.72 -7.18 -0.37 4.66e-12 Cholesterol, total; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.68 10.5 0.5 1.75e-22 Lymphocyte counts; LUSC cis rs3755132 0.929 rs2302935 chr2:15753482 C/G cg12888861 chr2:15731646 DDX1 0.52 7.48 0.38 6.45e-13 Wilms tumor; LUSC cis rs13082711 0.911 rs923941 chr3:27458914 A/G cg02860705 chr3:27208620 NA 0.52 8.71 0.43 1.44e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs11785693 0.862 rs6994323 chr8:4996786 T/A cg26367366 chr8:4980734 NA 0.73 8.61 0.43 2.9e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs1062746 0.544 rs8059287 chr16:87332956 G/A cg02258303 chr16:87377426 FBXO31 -0.53 -7.9 -0.4 4.15e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs4363385 0.747 rs4845333 chr1:152982877 G/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.33e-13 Inflammatory skin disease; LUSC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg09323728 chr8:95962352 TP53INP1 0.37 7.08 0.36 8.39e-12 Type 2 diabetes; LUSC cis rs116988415 0.584 rs2269308 chr14:65244950 G/A cg00114569 chr14:65239327 SPTB 0.6 6.55 0.34 2.23e-10 Daytime sleep phenotypes; LUSC cis rs11785400 0.793 rs11785012 chr8:143748355 G/A cg10596483 chr8:143751796 JRK 0.51 7.31 0.37 1.95e-12 Schizophrenia; LUSC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg12463550 chr7:65579703 CRCP 0.5 6.97 0.36 1.7e-11 Aortic root size; LUSC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.87e-12 Blood metabolite levels; LUSC cis rs4690686 1.000 rs2278904 chr4:177248622 C/G cg17059388 chr4:177262070 NA -0.35 -6.9 -0.35 2.64e-11 Essential tremor; LUSC cis rs4363385 0.747 rs2339495 chr1:152975116 A/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC trans rs9392918 0.967 rs9379130 chr6:7702659 C/G cg12631351 chr5:80256738 RASGRF2 0.35 6.06 0.31 3.59e-9 Height; LUSC cis rs2274273 0.529 rs10131562 chr14:55847015 G/A cg04306507 chr14:55594613 LGALS3 0.47 9.45 0.46 6.31e-19 Protein biomarker; LUSC cis rs6087990 0.735 rs2424915 chr20:31378448 C/T cg13636640 chr20:31349939 DNMT3B 0.86 16.76 0.68 3.37e-46 Ulcerative colitis; LUSC cis rs7824557 0.603 rs2249804 chr8:11215617 C/G cg21775007 chr8:11205619 TDH 0.74 11.51 0.53 4.7e-26 Retinal vascular caliber; LUSC cis rs7927592 0.913 rs11228287 chr11:68349754 A/G cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.58e-9 Total body bone mineral density; LUSC trans rs6502050 0.835 rs7218857 chr17:80161000 T/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.81e-10 Life satisfaction; LUSC cis rs17401966 0.838 rs7553935 chr1:10375179 G/A cg19773385 chr1:10388646 KIF1B -0.49 -8.37 -0.42 1.57e-15 Hepatocellular carcinoma; LUSC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg16520312 chr17:43971471 MAPT;LOC100128977 -0.38 -6.43 -0.33 4.51e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6964587 1.000 rs416 chr7:91580571 A/G cg22709100 chr7:91322751 NA -0.38 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg17294928 chr15:75287854 SCAMP5 0.43 6.21 0.32 1.54e-9 Breast cancer; LUSC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.66 0.39 2.02e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs921968 0.573 rs684776 chr2:219324016 T/C cg02176678 chr2:219576539 TTLL4 0.73 14.11 0.61 8.53e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.583 rs6601585 chr8:11233659 A/G cg21775007 chr8:11205619 TDH -0.68 -10.68 -0.5 4.35e-23 Retinal vascular caliber; LUSC cis rs77633900 0.614 rs280024 chr15:77034518 A/C cg21673338 chr15:77095150 SCAPER -0.82 -8.07 -0.4 1.26e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs4589502 1.000 rs75502100 chr15:67131417 T/C cg09911534 chr15:67153556 NA -0.69 -7.34 -0.37 1.67e-12 Lung cancer (smoking interaction); LUSC cis rs9888739 0.800 rs1143683 chr16:31336888 A/G cg15817542 chr16:31343056 ITGAM 0.47 6.63 0.34 1.39e-10 Systemic lupus erythematosus; LUSC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg16647868 chr5:131706066 SLC22A5 -0.39 -5.77 -0.3 1.77e-8 Breast cancer; LUSC cis rs7246657 0.653 rs10406612 chr19:37716611 C/T cg23950597 chr19:37808831 NA -0.61 -6.32 -0.33 8.32e-10 Coronary artery calcification; LUSC cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg05347473 chr6:146136440 FBXO30 -0.6 -10.43 -0.5 3.17e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs4499344 0.730 rs2545357 chr19:33104610 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.06 0.58 9.33e-32 Mean platelet volume; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.88 0.48 2.3e-20 Bipolar disorder; LUSC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg11941060 chr3:133502564 NA -0.46 -6.62 -0.34 1.4e-10 Iron status biomarkers; LUSC cis rs9646944 0.501 rs10186052 chr2:103079608 G/A cg20060108 chr2:102954350 IL1RL1 0.45 6.18 0.32 1.91e-9 Blood protein levels; LUSC cis rs1865760 1.000 rs6910138 chr6:25904352 C/G cg16482183 chr6:26056742 HIST1H1C 0.44 6.57 0.34 1.92e-10 Height; LUSC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6688613 0.685 rs4657613 chr1:166870878 A/G cg07049167 chr1:166818506 POGK 0.44 6.73 0.35 7.52e-11 Refractive astigmatism; LUSC cis rs2625529 0.642 rs2200056 chr15:72302667 T/C cg16672083 chr15:72433130 SENP8 -0.52 -7.49 -0.38 6.03e-13 Red blood cell count; LUSC cis rs9399135 0.660 rs9389248 chr6:135282656 T/C cg22676075 chr6:135203613 NA 0.54 8.55 0.42 4.6e-16 Red blood cell count; LUSC trans rs11992162 0.573 rs61468577 chr8:11784925 A/C cg08975724 chr8:8085496 FLJ10661 -0.43 -6.09 -0.32 3.17e-9 Monocyte count; LUSC trans rs10256972 0.641 rs12702017 chr7:1129413 C/T cg13565492 chr6:43139072 SRF -0.41 -5.99 -0.31 5.45e-9 Longevity;Endometriosis; LUSC cis rs2832191 0.967 rs1999321 chr21:30530233 A/C cg24692254 chr21:30365293 RNF160 0.78 13.63 0.6 6.17e-34 Dental caries; LUSC cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.35 5.81 0.3 1.48e-8 IgG glycosylation; LUSC trans rs7647973 0.710 rs12637313 chr3:49645458 A/G cg21659725 chr3:3221576 CRBN -0.71 -7.8 -0.39 7.78e-14 Menarche (age at onset); LUSC cis rs9788682 0.747 rs16969894 chr15:78776456 C/T cg18825076 chr15:78729989 IREB2 0.47 6.54 0.34 2.29e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2014572 0.967 rs8106734 chr19:57763546 C/T cg12963866 chr19:57752005 ZNF805 -0.39 -5.78 -0.3 1.73e-8 Hyperactive-impulsive symptoms; LUSC cis rs2298450 0.717 rs9974041 chr21:37634873 G/A cg02919814 chr21:37666008 DOPEY2 -0.51 -7.34 -0.37 1.67e-12 Schizophrenia; LUSC cis rs7599312 0.586 rs7571561 chr2:213386267 T/C cg16329650 chr2:213403929 ERBB4 0.52 7.56 0.38 3.92e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg03233332 chr7:66118400 NA 0.42 6.02 0.31 4.64e-9 Aortic root size; LUSC cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg05283184 chr6:79620031 NA -0.56 -11.88 -0.54 2.27e-27 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.867 rs7926002 chr11:49616018 A/G cg03929089 chr4:120376271 NA -0.99 -17.08 -0.68 1.85e-47 Height; LUSC cis rs644799 0.542 rs10831415 chr11:95466159 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.65 9.58 0.46 2.32e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9467773 0.620 rs2504571 chr6:26643435 C/T cg09904177 chr6:26538194 HMGN4 0.64 11.43 0.53 9.16e-26 Intelligence (multi-trait analysis); LUSC cis rs6424115 0.830 rs2501426 chr1:24199364 G/A cg10978503 chr1:24200527 CNR2 0.54 13.21 0.59 2.32e-32 Immature fraction of reticulocytes; LUSC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg16060761 chr17:80687452 NA 0.42 6.59 0.34 1.75e-10 Breast cancer; LUSC cis rs7605827 0.930 rs4571032 chr2:15685038 A/G cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC trans rs17685 0.672 rs56343450 chr7:75796235 C/T cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 13.65 0.6 5.02e-34 Platelet count; LUSC cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg20573242 chr4:122745356 CCNA2 0.53 7.85 0.39 5.6e-14 Type 2 diabetes; LUSC trans rs877282 0.891 rs11253406 chr10:796297 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg22875332 chr1:76189707 ACADM 0.77 12.03 0.55 6.19e-28 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6430585 0.591 rs309118 chr2:136746224 G/C cg07169764 chr2:136633963 MCM6 1.05 16.74 0.68 4.06e-46 Corneal structure; LUSC cis rs6460942 0.908 rs74801929 chr7:12232715 C/G cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg12463550 chr7:65579703 CRCP 0.52 7.51 0.38 5.47e-13 Aortic root size; LUSC cis rs1865760 0.622 rs9295685 chr6:26071725 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 8.11 0.41 9.7e-15 Height; LUSC cis rs367943 0.712 rs13157609 chr5:112683583 G/A cg12552261 chr5:112820674 MCC 0.39 6.37 0.33 6.4e-10 Type 2 diabetes; LUSC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg13607699 chr17:42295918 UBTF -0.48 -7.64 -0.39 2.37e-13 Total body bone mineral density; LUSC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg08949735 chr16:89699720 DPEP1 -0.24 -5.87 -0.31 1.04e-8 Vitiligo; LUSC cis rs7647973 0.925 rs4955421 chr3:49218888 G/A cg07636037 chr3:49044803 WDR6 0.69 8.83 0.43 6.21e-17 Menarche (age at onset); LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs12682352 0.602 rs11783966 chr8:8665147 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.22 -0.32 1.51e-9 Neuroticism; LUSC trans rs2302464 1.000 rs73125993 chr4:15730513 T/C cg17675199 chr6:35436792 RPL10A -0.88 -6.15 -0.32 2.26e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs7772486 0.875 rs2748490 chr6:146329681 G/T cg23711669 chr6:146136114 FBXO30 0.84 15.05 0.64 1.97e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.45 -0.42 8.97e-16 Mood instability; LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg16145915 chr7:1198662 ZFAND2A -0.52 -10.27 -0.49 1.07e-21 Longevity;Endometriosis; LUSC cis rs3791556 0.898 rs3791549 chr2:240109024 A/G cg03281426 chr2:240109471 HDAC4 -0.56 -8.23 -0.41 4.16e-15 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2274273 0.588 rs7155054 chr14:55750662 A/G cg04306507 chr14:55594613 LGALS3 0.47 9.59 0.46 2.15e-19 Protein biomarker; LUSC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg17554472 chr22:41940697 POLR3H -0.49 -6.03 -0.31 4.38e-9 Vitiligo; LUSC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg02038168 chr22:39784481 NA 0.45 6.7 0.34 9.04e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9443189 0.570 rs6903124 chr6:76290079 A/C cg01950844 chr6:76311363 SENP6 0.7 6.97 0.36 1.74e-11 Prostate cancer; LUSC trans rs2243480 1.000 rs58062456 chr7:65394852 G/T cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.56e-13 Motion sickness; LUSC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.91 0.44 3.4e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs6960043 1.000 rs12666046 chr7:15050381 A/G cg19272540 chr7:15055459 NA -0.31 -7.41 -0.38 1.01e-12 Type 2 diabetes; LUSC cis rs61931739 0.534 rs4931775 chr12:34050729 G/A cg06521331 chr12:34319734 NA -0.47 -7.63 -0.39 2.42e-13 Morning vs. evening chronotype; LUSC cis rs4704187 0.687 rs10942729 chr5:74364300 C/T cg03227963 chr5:74354835 NA 0.32 7.13 0.36 6.4e-12 Response to amphetamines; LUSC cis rs12950390 0.853 rs11655112 chr17:45856563 T/C cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.51e-10 IgG glycosylation; LUSC cis rs7818345 0.935 rs6991212 chr8:19276522 C/T cg11303988 chr8:19266685 CSGALNACT1 0.37 7.12 0.36 6.47e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7312933 0.618 rs6582394 chr12:42686189 A/G cg17420585 chr12:42539391 GXYLT1 -0.32 -5.97 -0.31 6.02e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs8064299 0.597 rs6501737 chr17:72780830 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.89 -18.22 -0.71 5.27e-52 Monocyte count; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg10360139 chr7:1886902 MAD1L1 -0.38 -5.76 -0.3 1.91e-8 Bipolar disorder and schizophrenia; LUSC cis rs597583 0.671 rs4938401 chr11:117399605 T/G cg27161313 chr11:117392002 DSCAML1 -0.51 -8.02 -0.4 1.81e-14 Putamen volume; LUSC trans rs6787172 1.000 rs6787172 chr3:158187811 T/G cg23275840 chr4:47708675 CORIN -0.27 -6.03 -0.31 4.45e-9 Subjective well-being; LUSC cis rs611744 0.870 rs633794 chr8:109174702 A/G cg18478394 chr8:109455254 TTC35 0.43 6.39 0.33 5.65e-10 Dupuytren's disease; LUSC cis rs10992471 0.603 rs12341817 chr9:95252152 C/T cg14631576 chr9:95140430 CENPP -0.33 -5.96 -0.31 6.48e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs62238980 0.614 rs734091 chr22:32461891 A/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC trans rs4714291 0.925 rs847784 chr6:40053272 A/G cg02267698 chr19:7991119 CTXN1 0.54 7.52 0.38 5.19e-13 Strep throat; LUSC cis rs477692 1.000 rs516704 chr10:131419879 G/A cg26102564 chr10:131424627 MGMT 0.38 5.94 0.31 7.21e-9 Response to temozolomide; LUSC cis rs9303401 0.625 rs10515159 chr17:56802693 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg03060546 chr3:49711283 APEH -0.69 -10.06 -0.48 5.62e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC trans rs7681440 0.874 rs10028246 chr4:90766704 G/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs7267979 1.000 rs4815405 chr20:25317492 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.51 -0.75 4.63e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg27170947 chr2:26402098 FAM59B -0.7 -10.76 -0.51 2.21e-23 Gut microbiome composition (summer); LUSC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg03676636 chr4:99064102 C4orf37 0.38 8.09 0.4 1.14e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg13010199 chr12:38710504 ALG10B 0.67 10.36 0.49 5.56e-22 Heart rate; LUSC cis rs9467773 0.967 rs6941022 chr6:26553531 T/C cg05738196 chr6:26577821 NA 0.83 16.11 0.66 1.29e-43 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg04234412 chr22:24373322 LOC391322 -0.87 -14.96 -0.63 4.27e-39 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17685 0.884 rs3823882 chr7:75631913 T/C cg16489192 chr7:75678113 MDH2;STYXL1 0.45 6.65 0.34 1.16e-10 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs35146811 0.735 rs1727140 chr7:99815399 T/A cg13334819 chr7:99746414 C7orf59 0.5 6.76 0.35 6.07e-11 Coronary artery disease; LUSC trans rs724744 0.742 rs1737224 chr6:22355309 T/C cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg20848291 chr7:100343083 ZAN -0.55 -8.03 -0.4 1.72e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.33e-8 Diabetic kidney disease; LUSC cis rs9472414 0.510 rs7746032 chr6:44708613 A/T cg20913747 chr6:44695427 NA 0.38 5.77 0.3 1.81e-8 Height; LUSC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg25319279 chr11:5960081 NA -0.39 -6.04 -0.31 4.07e-9 DNA methylation (variation); LUSC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg06108461 chr20:60628389 TAF4 -1.01 -17.18 -0.68 7.55e-48 Body mass index; LUSC cis rs7615952 0.866 rs6438949 chr3:125650064 G/C cg05084668 chr3:125655381 ALG1L -0.76 -11.44 -0.53 8.62e-26 Blood pressure (smoking interaction); LUSC cis rs6840360 1.000 rs6849050 chr4:152599902 C/T cg22705602 chr4:152727874 NA -0.27 -5.74 -0.3 2.14e-8 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.681 rs2271342 chr8:8643938 C/T cg06636001 chr8:8085503 FLJ10661 0.6 9.3 0.45 1.94e-18 Mood instability; LUSC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg19717773 chr7:2847554 GNA12 -0.32 -5.77 -0.3 1.84e-8 Height; LUSC cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg02153584 chr22:29168773 CCDC117 0.59 8.91 0.44 3.47e-17 Lymphocyte counts; LUSC cis rs734999 0.549 rs867436 chr1:2523723 C/T cg18932078 chr1:2524107 MMEL1 0.31 6.74 0.35 6.76e-11 Ulcerative colitis; LUSC cis rs4930561 0.765 rs4930564 chr11:67983281 C/T cg16338278 chr11:67432957 ALDH3B2 -0.36 -5.89 -0.31 9.38e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg03060546 chr3:49711283 APEH 0.7 11.63 0.54 1.78e-26 Resting heart rate; LUSC cis rs1595825 0.838 rs57437055 chr2:198782617 A/C cg10547527 chr2:198650123 BOLL -0.49 -5.79 -0.3 1.65e-8 Ulcerative colitis; LUSC cis rs7937890 1.000 rs2970335 chr11:14325401 A/C cg22961513 chr11:14280813 SPON1 -0.35 -5.82 -0.3 1.39e-8 Mitochondrial DNA levels; LUSC cis rs11758351 1.000 rs75921373 chr6:26191843 C/T cg23601095 chr6:26197514 HIST1H3D 0.71 7.35 0.37 1.57e-12 Gout;Renal underexcretion gout; LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg22535103 chr8:58192502 C8orf71 -0.58 -7.13 -0.36 6.16e-12 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.930 rs11691392 chr2:15498781 C/T cg19274914 chr2:15703543 NA 0.45 8.51 0.42 6.15e-16 Educational attainment (years of education); LUSC cis rs61931739 0.500 rs7312938 chr12:34378708 C/T cg06521331 chr12:34319734 NA -0.42 -6.58 -0.34 1.86e-10 Morning vs. evening chronotype; LUSC trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg25482853 chr8:67687455 SGK3 1.2 17.23 0.69 4.62e-48 Lung disease severity in cystic fibrosis; LUSC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg14668632 chr7:2872130 GNA12 -0.41 -6.22 -0.32 1.5e-9 Height; LUSC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg05373962 chr22:49881684 NA -0.41 -9.73 -0.47 7.4e-20 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg12011299 chr4:100065546 ADH4 -0.71 -11.17 -0.52 7.69e-25 Alcohol dependence; LUSC cis rs7408868 1.000 rs7250232 chr19:15277199 C/T cg14696996 chr19:15285081 NOTCH3 0.94 7.81 0.39 7.61e-14 Pulse pressure; LUSC cis rs9467773 1.000 rs6932156 chr6:26571506 T/G cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.7e-36 Intelligence (multi-trait analysis); LUSC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg06808227 chr14:105710500 BRF1 0.71 11.45 0.53 7.98e-26 Mean platelet volume;Platelet distribution width; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13941441 chr2:190649374 PMS1;ORMDL1 0.47 6.42 0.33 4.78e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12497850 0.863 rs4858799 chr3:48728204 G/C cg07636037 chr3:49044803 WDR6 0.94 15.3 0.64 1.96e-40 Parkinson's disease; LUSC cis rs55871839 0.643 rs7004274 chr8:59810378 T/A cg07426533 chr8:59803705 TOX -0.37 -5.93 -0.31 7.5e-9 Pneumonia; LUSC cis rs765787 0.505 rs12593605 chr15:45497448 T/A cg25801113 chr15:45476975 SHF -0.33 -6.48 -0.33 3.28e-10 Uric acid levels; LUSC cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg07424592 chr7:64974309 NA 0.7 6.2 0.32 1.67e-9 Diabetic kidney disease; LUSC cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg07606381 chr6:8435919 SLC35B3 0.73 12.5 0.56 1.14e-29 Motion sickness; LUSC cis rs6733011 0.519 rs12712037 chr2:99463025 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.01 -0.31 4.84e-9 Bipolar disorder; LUSC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.28e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg08773314 chr2:239334832 ASB1 0.43 9.27 0.45 2.35e-18 Multiple system atrophy; LUSC cis rs4295623 0.504 rs11250160 chr8:11592717 G/A cg00262122 chr8:11665843 FDFT1 -0.44 -6.66 -0.34 1.12e-10 Morning vs. evening chronotype; LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg08027265 chr7:2291960 NA 0.35 5.65 0.3 3.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg12311346 chr5:56204834 C5orf35 -0.94 -13.51 -0.59 1.68e-33 Initial pursuit acceleration; LUSC trans rs6076960 0.652 rs3852946 chr20:6255311 C/T cg21095983 chr6:86352623 SYNCRIP 0.5 8.07 0.4 1.25e-14 Smooth-surface caries; LUSC cis rs2439831 0.850 rs28524541 chr15:44124831 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.98 0.44 2e-17 Lung cancer in ever smokers; LUSC cis rs6693567 0.526 rs3818978 chr1:150266338 T/A cg09579323 chr1:150459698 TARS2 -0.41 -5.77 -0.3 1.83e-8 Migraine; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.6 10.09 0.48 4.37e-21 Lymphocyte counts; LUSC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9467160 0.520 rs2753910 chr6:24442473 C/T cg20631270 chr6:24437470 GPLD1 -0.39 -6.16 -0.32 2.13e-9 Liver enzyme levels; LUSC cis rs11126435 0.565 rs715407 chr2:74765693 G/T cg04255230 chr2:74727010 LBX2 0.4 5.87 0.31 1.08e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7043114 0.525 rs12353096 chr9:95031144 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.21 -0.32 1.57e-9 Height; LUSC cis rs35995292 0.553 rs2392605 chr7:38924670 T/C cg19327137 chr7:38886074 VPS41 0.54 10.22 0.49 1.65e-21 Subjective well-being (multi-trait analysis); LUSC cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg05855489 chr10:104503620 C10orf26 0.61 9.8 0.47 4.43e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs710216 0.752 rs841848 chr1:43402545 G/A cg03128534 chr1:43423976 SLC2A1 0.45 5.68 0.3 2.95e-8 Red cell distribution width; LUSC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg22029157 chr1:209979665 IRF6 0.52 8.21 0.41 4.96e-15 Monobrow; LUSC cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg22349387 chr12:9600060 DDX12 -0.37 -5.65 -0.3 3.39e-8 Breast size; LUSC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg16535667 chr11:65410126 SIPA1 -0.46 -6.05 -0.31 3.82e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg08048268 chr3:133502702 NA -0.41 -7.42 -0.38 9.57e-13 Iron status biomarkers; LUSC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg22903471 chr2:27725779 GCKR -0.41 -7.05 -0.36 1.05e-11 Total body bone mineral density; LUSC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg20503657 chr10:835505 NA 1.05 13.48 0.59 2.19e-33 Eosinophil percentage of granulocytes; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC cis rs4253772 0.872 rs45528736 chr22:46638312 A/G cg18190219 chr22:46762943 CELSR1 -0.48 -5.81 -0.3 1.45e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10582045 chr15:43477796 CCNDBP1 -0.48 -6.27 -0.32 1.09e-9 Bipolar disorder and schizophrenia; LUSC cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg14500267 chr11:67383377 NA -0.32 -5.81 -0.3 1.44e-8 Mean corpuscular volume; LUSC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg08677398 chr8:58056175 NA 0.44 5.86 0.31 1.11e-8 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg19346786 chr7:2764209 NA -0.46 -7.92 -0.4 3.5e-14 Height; LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg22535103 chr8:58192502 C8orf71 -0.62 -7.32 -0.37 1.85e-12 Developmental language disorder (linguistic errors); LUSC cis rs17021463 0.934 rs28403447 chr4:95257753 G/A cg11021082 chr4:95130006 SMARCAD1 0.41 7.67 0.39 1.84e-13 Testicular germ cell tumor; LUSC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg26566898 chr11:117069891 TAGLN 0.48 8.3 0.41 2.63e-15 Blood protein levels; LUSC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg23719950 chr11:63933701 MACROD1 -0.62 -8.07 -0.4 1.26e-14 Mean platelet volume; LUSC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg13114125 chr14:105738426 BRF1 -0.92 -16.04 -0.66 2.55e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs4619890 0.528 rs28437157 chr4:7874435 C/A cg24250820 chr4:7887609 AFAP1 0.36 6.1 0.32 2.88e-9 Glaucoma (primary open-angle); LUSC cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.4 0.53 1.17e-25 Colorectal cancer; LUSC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg00310523 chr12:86230176 RASSF9 0.46 8.4 0.42 1.32e-15 Major depressive disorder; LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC cis rs2439831 0.681 rs3742969 chr15:43621947 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.11 15.06 0.64 1.73e-39 Lung cancer in ever smokers; LUSC cis rs17540621 0.744 rs114700821 chr2:47185714 C/T cg23978866 chr2:47230407 TTC7A -0.9 -6.69 -0.34 9.42e-11 Response to statin therapy; LUSC cis rs17270561 0.609 rs7746502 chr6:25718762 T/A cg17691542 chr6:26056736 HIST1H1C -0.5 -7.19 -0.37 4.37e-12 Iron status biomarkers; LUSC cis rs9325144 0.600 rs1825807 chr12:38737007 T/C cg26384229 chr12:38710491 ALG10B 0.6 9.59 0.46 2.2e-19 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26386436 chr14:90084672 FOXN3 0.4 6.06 0.31 3.75e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs73206853 0.563 rs16940950 chr12:111136459 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 7.36 0.37 1.45e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7561273 0.609 rs6545285 chr2:24340029 T/C cg20701182 chr2:24300061 SF3B14 0.45 5.83 0.3 1.32e-8 Quantitative traits; LUSC cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg14689365 chr7:158441557 NCAPG2 0.53 7.59 0.38 3.25e-13 Height; LUSC cis rs1178968 1.000 rs1178959 chr7:72777093 T/C cg25889504 chr7:72793014 NA 0.6 7.77 0.39 9.92e-14 Triglyceride levels; LUSC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg15605315 chr1:45957053 TESK2 0.51 8.44 0.42 1e-15 High light scatter reticulocyte count; LUSC cis rs7267979 0.932 rs6138588 chr20:25487523 C/T cg08601574 chr20:25228251 PYGB 0.41 6.21 0.32 1.61e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.97 0.4 2.55e-14 Electroencephalogram traits; LUSC cis rs10911232 0.524 rs4487994 chr1:182982173 T/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Hypertriglyceridemia; LUSC cis rs6554196 0.525 rs2237036 chr4:55526175 G/C cg18836493 chr4:55524333 KIT -0.44 -7.55 -0.38 4.2e-13 Monocyte count; LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg26314531 chr2:26401878 FAM59B -0.7 -9.75 -0.47 6.29e-20 Gut microbiome composition (summer); LUSC cis rs2880765 0.566 rs17553790 chr15:86013665 C/T cg10818794 chr15:86012489 AKAP13 0.41 6.49 0.33 3.13e-10 Coronary artery disease; LUSC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.95 0.36 1.94e-11 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.697 rs28458294 chr4:120238924 T/C cg09307838 chr4:120376055 NA 0.71 10.61 0.5 7.43e-23 Corneal astigmatism; LUSC cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.77 -0.35 5.76e-11 Monocyte percentage of white cells; LUSC trans rs9944715 0.911 rs7230995 chr18:43786822 G/A cg01718231 chr17:29326311 RNF135 -0.54 -7.66 -0.39 2.03e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs9611565 1.000 rs5758314 chr22:41762523 T/G cg03806693 chr22:41940476 POLR3H -0.73 -10.48 -0.5 2.04e-22 Vitiligo; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg01238044 chr22:24384105 GSTT1 -0.62 -9.95 -0.48 1.3e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6121246 0.529 rs7261354 chr20:30202414 T/C cg13852791 chr20:30311386 BCL2L1 0.73 8.39 0.42 1.35e-15 Mean corpuscular hemoglobin; LUSC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg13206674 chr6:150067644 NUP43 0.57 8.9 0.44 3.62e-17 Lung cancer; LUSC cis rs7527798 0.571 rs11118237 chr1:207818719 G/A cg09232269 chr1:207846808 CR1L -0.31 -6.46 -0.33 3.68e-10 Erythrocyte sedimentation rate; LUSC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg04414720 chr1:150670196 GOLPH3L 0.49 7.77 0.39 9.49e-14 Melanoma; LUSC cis rs73206853 0.841 rs9783428 chr12:111068096 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.17 0.37 4.73e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7577696 0.752 rs12995952 chr2:32373298 C/T cg02381751 chr2:32503542 YIPF4 -0.41 -5.67 -0.3 3.14e-8 Inflammatory biomarkers; LUSC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg20307385 chr11:47447363 PSMC3 -0.45 -5.95 -0.31 6.79e-9 Subjective well-being; LUSC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg00343986 chr7:65444356 GUSB -0.43 -6.63 -0.34 1.32e-10 Aortic root size; LUSC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg20135002 chr11:47629003 NA -0.5 -7.78 -0.39 9.27e-14 Subjective well-being; LUSC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg22834771 chr12:69754056 YEATS4 -0.49 -7.37 -0.37 1.31e-12 Blood protein levels; LUSC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg00033643 chr7:134001901 SLC35B4 0.44 6.72 0.35 7.83e-11 Mean platelet volume; LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg04518342 chr5:131593106 PDLIM4 0.45 7.89 0.4 4.3e-14 Breast cancer; LUSC cis rs2806561 0.577 rs488438 chr1:23498999 T/A cg19743168 chr1:23544995 NA 0.43 8.03 0.4 1.68e-14 Height; LUSC cis rs3126085 0.935 rs3126091 chr1:152307338 T/C cg26876637 chr1:152193138 HRNR -0.44 -6.02 -0.31 4.67e-9 Atopic dermatitis; LUSC cis rs10746514 0.833 rs10864720 chr1:232271232 C/T cg09506761 chr1:232265262 NA -0.57 -9.72 -0.47 7.91e-20 Response to statin therapy; LUSC cis rs12545109 0.800 rs2670055 chr8:57421575 T/C cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg08219700 chr8:58056026 NA 0.69 7.93 0.4 3.34e-14 Developmental language disorder (linguistic errors); LUSC cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs11190604 1.000 rs12219158 chr10:102302923 T/C cg16342193 chr10:102329863 NA -0.35 -6.22 -0.32 1.53e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7584330 0.554 rs62186170 chr2:238425883 C/T cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg24846343 chr22:24311635 DDTL -0.75 -16.85 -0.68 1.51e-46 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg21775007 chr8:11205619 TDH 0.43 6.24 0.32 1.32e-9 Neuroticism; LUSC cis rs912057 0.932 rs1294406 chr6:6737737 A/G cg06612196 chr6:6737390 NA 0.55 10.65 0.5 5.16e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg18876405 chr7:65276391 NA 0.48 6.59 0.34 1.73e-10 Corneal structure; LUSC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.42 -6.15 -0.32 2.17e-9 Schizophrenia; LUSC cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg16586182 chr3:47516702 SCAP -0.49 -7.59 -0.38 3.1400000000000003e-13 Colorectal cancer; LUSC cis rs2236918 1.000 rs1629051 chr1:242026344 A/G cg17736920 chr1:242011382 EXO1 -0.45 -7.26 -0.37 2.68e-12 Menopause (age at onset); LUSC cis rs7940866 0.903 rs10791109 chr11:130850377 A/C cg12179176 chr11:130786555 SNX19 0.56 8.87 0.44 4.57e-17 Schizophrenia; LUSC cis rs701145 0.585 rs1358405 chr3:153810992 A/G cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg02675527 chr2:114030824 PAX8;LOC440839 0.38 5.94 0.31 6.98e-9 Lymphocyte counts; LUSC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15541040 chr2:3486749 NA -0.58 -9.21 -0.45 3.59e-18 Neurofibrillary tangles; LUSC cis rs9303401 0.615 rs7502342 chr17:56922629 C/A cg25039879 chr17:56429692 SUPT4H1 0.67 8.95 0.44 2.48e-17 Cognitive test performance; LUSC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg09323728 chr8:95962352 TP53INP1 0.3 5.92 0.31 8.17e-9 Type 2 diabetes; LUSC cis rs2836633 0.929 rs4143428 chr21:40030582 G/T cg05519781 chr21:40033154 ERG 0.77 13.33 0.59 8.19e-33 Coronary artery disease; LUSC cis rs4268898 0.662 rs56006260 chr2:24409903 A/G cg06627628 chr2:24431161 ITSN2 -0.86 -12.09 -0.55 3.55e-28 Asthma; LUSC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg18306943 chr3:40428807 ENTPD3 0.38 5.73 0.3 2.2e-8 Renal cell carcinoma; LUSC cis rs77106637 0.932 rs17244499 chr11:72629946 C/T cg04827223 chr11:72435913 ARAP1 0.66 8.73 0.43 1.28e-16 Type 2 diabetes; LUSC cis rs9902453 1.000 rs60967688 chr17:28437052 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.74 0.43 1.17e-16 Coffee consumption (cups per day); LUSC cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg14438399 chr17:27053147 TLCD1 0.52 5.75 0.3 2.05e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1691799 0.867 rs1168343 chr12:66758581 C/T cg16791601 chr12:66731901 HELB -0.71 -12.37 -0.56 3.47e-29 White blood cell count (basophil); LUSC cis rs782590 0.729 rs706548 chr2:55850106 C/G cg18811423 chr2:55921094 PNPT1 0.73 12.03 0.55 6.29e-28 Metabolic syndrome; LUSC cis rs929354 0.605 rs7806314 chr7:156946903 A/T cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC trans rs6502050 0.835 rs34673303 chr17:80085144 G/C cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg00599273 chr12:58146742 CDK4 0.31 5.96 0.31 6.44e-9 Multiple sclerosis; LUSC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg20891558 chr2:74357851 NA 0.85 15.52 0.65 2.67e-41 Gestational age at birth (maternal effect); LUSC cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.73e-15 Homoarginine levels; LUSC cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg15839431 chr19:19639596 YJEFN3 0.65 7.27 0.37 2.63e-12 Bipolar disorder; LUSC cis rs12541635 0.677 rs7819501 chr8:107006962 C/T cg10147462 chr8:107024639 NA -0.67 -13.67 -0.6 4.34e-34 Age of smoking initiation; LUSC cis rs9788682 0.747 rs28511883 chr15:78783683 C/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.98 -0.31 5.88e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7914558 0.933 rs2066323 chr10:104871361 A/G cg05855489 chr10:104503620 C10orf26 0.6 9.68 0.47 1.05e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7208859 0.623 rs55638872 chr17:29149552 G/C cg13385521 chr17:29058706 SUZ12P 0.65 6.26 0.32 1.18e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.14 -0.32 2.28e-9 IgG glycosylation; LUSC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.72 -0.39 1.4e-13 Aortic root size; LUSC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg14582100 chr15:45693742 SPATA5L1 0.59 10.79 0.51 1.81e-23 Homoarginine levels; LUSC cis rs17255340 0.539 rs1144194 chr6:83978378 G/A cg08257003 chr6:84140564 ME1 0.32 7.72 0.39 1.37e-13 Platelet-derived growth factor BB levels; LUSC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg14552801 chr7:65878734 NA -0.38 -5.86 -0.31 1.08e-8 Aortic root size; LUSC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg20887711 chr4:1340912 KIAA1530 0.43 6.55 0.34 2.13e-10 Obesity-related traits; LUSC cis rs7666738 0.609 rs35214820 chr4:98864692 G/A cg05340658 chr4:99064831 C4orf37 0.61 8.89 0.44 3.83e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7177699 0.526 rs7165042 chr15:79123338 C/G cg00540400 chr15:79124168 NA 0.43 7.51 0.38 5.44e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs314370 0.951 rs12667888 chr7:100474289 T/C cg08558340 chr7:100472263 SRRT 0.5 6.23 0.32 1.37e-9 Resting heart rate; LUSC cis rs6087990 0.735 rs2424920 chr20:31385452 T/C cg13636640 chr20:31349939 DNMT3B 0.9 18.2 0.71 6.72e-52 Ulcerative colitis; LUSC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg24675056 chr1:15929824 NA 0.47 8.07 0.4 1.32e-14 Systolic blood pressure; LUSC cis rs7582720 1.000 rs72936332 chr2:204056678 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.29 0.41 2.71e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09241243 chr14:64970743 ZBTB25;ZBTB1 0.45 6.01 0.31 4.94e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06077733 chr10:60094879 UBE2D1 -0.44 -6.65 -0.34 1.17e-10 Electrocardiographic conduction measures; LUSC cis rs8062405 0.824 rs153106 chr16:28526897 T/C cg00204512 chr16:28754710 NA 0.32 5.67 0.3 3.15e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9583531 0.689 rs4773244 chr13:111383937 A/T cg24331049 chr13:111365604 ING1 -0.63 -8.49 -0.42 6.97e-16 Coronary artery disease; LUSC cis rs61863818 0.709 rs10786343 chr10:99159465 C/A cg20016023 chr10:99160130 RRP12 -0.31 -7.55 -0.38 4.1e-13 Monocyte percentage of white cells; LUSC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg01448562 chr3:133502909 NA -0.65 -10.61 -0.5 7.25e-23 Iron status biomarkers; LUSC cis rs4243830 0.850 rs12410405 chr1:6581283 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.79 9.79 0.47 4.75e-20 Body mass index; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg17178900 chr1:205818956 PM20D1 -0.49 -7.42 -0.38 9.63e-13 Menarche (age at onset); LUSC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg05861140 chr6:150128134 PCMT1 0.4 6.46 0.33 3.77e-10 Lung cancer; LUSC cis rs7264396 0.790 rs2425097 chr20:34308926 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.52 -0.46 3.57e-19 Total cholesterol levels; LUSC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg13902645 chr11:5959945 NA -0.57 -8.08 -0.4 1.22e-14 DNA methylation (variation); LUSC cis rs6582630 0.599 rs11181807 chr12:38403763 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.71e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs6867032 0.527 rs13153217 chr5:2012788 G/T cg26168224 chr5:2018326 NA -0.48 -7.99 -0.4 2.24e-14 Gut microbiome composition (winter); LUSC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg13628971 chr7:2884303 GNA12 0.5 6.92 0.35 2.38e-11 Height; LUSC cis rs3784262 0.679 rs11071366 chr15:58334244 A/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -6.71 -0.34 8.23e-11 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs953492 0.583 rs10803125 chr1:243380376 G/C cg25284624 chr1:224180302 NA -0.44 -6.8 -0.35 4.95e-11 Diastolic blood pressure; LUSC cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 9.35 0.46 1.33e-18 IgG glycosylation; LUSC cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg20701182 chr2:24300061 SF3B14 0.77 7.74 0.39 1.17e-13 Lymphocyte counts; LUSC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.45 -6.42 -0.33 4.59e-10 Bipolar disorder; LUSC cis rs8017423 0.967 rs11159957 chr14:90715972 A/G cg14092571 chr14:90743983 NA 0.37 6.18 0.32 1.85e-9 Mortality in heart failure; LUSC cis rs9300255 0.602 rs1617434 chr12:123649486 A/G cg13010344 chr12:123464640 ARL6IP4 -0.47 -6.0 -0.31 5.26e-9 Neutrophil percentage of white cells; LUSC cis rs1451375 0.698 rs10899748 chr7:50646089 G/A cg18232548 chr7:50535776 DDC 0.45 6.2 0.32 1.7e-9 Malaria; LUSC cis rs6942756 0.806 rs2718115 chr7:128871532 A/G cg02491457 chr7:128862824 NA 0.54 8.13 0.41 8.51e-15 White matter hyperintensity burden; LUSC cis rs6977660 0.714 rs10270204 chr7:19819544 C/T cg07541023 chr7:19748670 TWISTNB 0.59 6.33 0.33 7.76e-10 Thyroid stimulating hormone; LUSC cis rs7582720 1.000 rs72926772 chr2:203804289 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10193935 0.901 rs2286701 chr2:42555636 T/C cg27598129 chr2:42591480 NA -0.6 -8.17 -0.41 6.36e-15 Colonoscopy-negative controls vs population controls; LUSC trans rs10435719 0.902 rs12681142 chr8:11802601 T/C cg15556689 chr8:8085844 FLJ10661 0.58 8.88 0.44 4.07e-17 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs3008870 0.755 rs2755243 chr1:67482783 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.3 0.56 5.99e-29 Lymphocyte percentage of white cells; LUSC cis rs2046867 0.818 rs62249875 chr3:72911858 G/A cg25664220 chr3:72788482 NA -0.62 -10.83 -0.51 1.27e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4268898 0.679 rs2543666 chr2:24446042 C/T cg06627628 chr2:24431161 ITSN2 0.82 12.21 0.56 1.33e-28 Asthma; LUSC trans rs11098499 0.909 rs28714195 chr4:120316950 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.02 0.31 4.65e-9 Corneal astigmatism; LUSC cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg16584290 chr5:462447 EXOC3 0.44 7.72 0.39 1.32e-13 Cystic fibrosis severity; LUSC cis rs7119 0.651 rs12902072 chr15:77848732 T/C cg27398640 chr15:77910606 LINGO1 -0.33 -6.79 -0.35 5.05e-11 Type 2 diabetes; LUSC cis rs13315871 0.929 rs17059171 chr3:58302586 A/G cg20936604 chr3:58311152 NA -0.67 -6.63 -0.34 1.37e-10 Cholesterol, total; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05588757 chr2:95825608 ZNF514 -0.48 -5.97 -0.31 6.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs41271473 0.526 rs72765760 chr1:228743222 G/A cg16512390 chr1:228756714 NA 0.73 9.66 0.47 1.25e-19 Chronic lymphocytic leukemia; LUSC cis rs4604732 0.631 rs12036460 chr1:247626928 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7647973 1.000 rs73088137 chr3:49448423 G/A cg07636037 chr3:49044803 WDR6 -0.67 -8.63 -0.43 2.63e-16 Menarche (age at onset); LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg00767846 chr2:170655407 SSB 0.4 6.31 0.33 8.94e-10 Eotaxin levels; LUSC cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg22467129 chr15:76604101 ETFA -0.44 -7.0 -0.36 1.44e-11 Blood metabolite levels; LUSC cis rs7264396 0.790 rs6060516 chr20:34214368 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.79 -0.47 4.54e-20 Total cholesterol levels; LUSC cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.07 -0.44 1.06e-17 Monocyte percentage of white cells; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg21724239 chr8:58056113 NA 0.79 9.06 0.44 1.13e-17 Developmental language disorder (linguistic errors); LUSC cis rs7937890 0.967 rs963212 chr11:14324732 A/G cg22961513 chr11:14280813 SPON1 0.34 5.7 0.3 2.65e-8 Mitochondrial DNA levels; LUSC cis rs4319547 0.695 rs10734915 chr12:122873408 A/C cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.23 -0.41 4.31e-15 Body mass index; LUSC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg13206674 chr6:150067644 NUP43 0.62 9.97 0.48 1.16e-20 Lung cancer; LUSC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs977987 0.815 rs11646677 chr16:75408981 T/C cg04384234 chr16:75411784 CFDP1 -0.45 -7.44 -0.38 8.86e-13 Dupuytren's disease; LUSC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg04315214 chr1:2043799 PRKCZ 0.4 8.09 0.4 1.15e-14 Height; LUSC cis rs7799006 0.929 rs35791351 chr7:2269248 C/T cg12823233 chr7:2316876 SNX8 -0.34 -5.89 -0.31 9.33e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg10547057 chr6:26987810 LOC100270746;C6orf41 0.37 6.94 0.36 2.01e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg02018176 chr4:1364513 KIAA1530 0.51 8.83 0.44 5.97e-17 Obesity-related traits; LUSC cis rs68170813 0.559 rs10953536 chr7:107021691 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.38 -0.46 1.02e-18 Coronary artery disease; LUSC cis rs10845606 1.000 rs10845610 chr12:12839107 G/A cg09462578 chr12:12878428 APOLD1 -0.53 -6.53 -0.34 2.43e-10 Systemic lupus erythematosus; LUSC cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg00321850 chr1:175162397 KIAA0040 -0.45 -7.72 -0.39 1.39e-13 Alcohol dependence; LUSC trans rs1994135 0.617 rs10844644 chr12:33735871 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.46 0.33 3.7e-10 Resting heart rate; LUSC cis rs6489882 0.510 rs61478890 chr12:113364375 A/G cg20102336 chr12:113376681 OAS3 -0.41 -5.89 -0.31 9.59e-9 Chronic lymphocytic leukemia; LUSC cis rs829883 0.724 rs11109507 chr12:98904160 C/T cg25150519 chr12:98850993 NA 0.62 8.51 0.42 5.92e-16 Colorectal adenoma (advanced); LUSC cis rs6700896 0.931 rs2889195 chr1:66156730 C/T cg04111102 chr1:66153794 NA 0.32 7.14 0.36 6.01e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs68170813 0.641 rs75639044 chr7:107092631 A/C cg02696742 chr7:106810147 HBP1 -0.66 -9.66 -0.47 1.21e-19 Coronary artery disease; LUSC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg12560992 chr17:57184187 TRIM37 0.89 16.62 0.67 1.3e-45 Intelligence (multi-trait analysis); LUSC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg20203395 chr5:56204925 C5orf35 -0.55 -7.69 -0.39 1.67e-13 Coronary artery disease; LUSC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg00339695 chr16:24857497 SLC5A11 -0.58 -8.57 -0.42 3.84e-16 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.27 0.41 3.25e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs951366 0.538 rs56276813 chr1:205730573 G/T cg24503407 chr1:205819492 PM20D1 -0.47 -6.25 -0.32 1.22e-9 Menarche (age at onset); LUSC cis rs2806561 0.929 rs6694445 chr1:23540428 A/G cg19743168 chr1:23544995 NA 0.45 9.82 0.47 3.57e-20 Height; LUSC trans rs1982346 1.000 rs2544426 chr4:106717797 C/T cg01484487 chr2:74726892 LBX2 -0.47 -5.95 -0.31 6.64e-9 Lung function (FEV1); LUSC cis rs500891 0.693 rs767144 chr6:83976802 G/T cg08257003 chr6:84140564 ME1 0.35 7.75 0.39 1.11e-13 Platelet-derived growth factor BB levels; LUSC cis rs4629180 0.675 rs10184144 chr2:102104978 C/T cg04415270 chr2:102091202 RFX8 -0.45 -7.88 -0.4 4.79e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7289126 0.868 rs2267377 chr22:38629519 T/C cg25457927 chr22:38595422 NA -0.29 -5.87 -0.31 1.04e-8 Mammographic density (dense area);Percent mammographic density; LUSC cis rs72781680 0.821 rs12616257 chr2:24135034 A/G cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg27129171 chr3:47204927 SETD2 0.7 11.75 0.54 6.42e-27 Colorectal cancer; LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs4691139 0.903 rs10434177 chr4:165915531 A/T cg11630554 chr4:165878136 TRIM61;C4orf39 -0.5 -5.74 -0.3 2.09e-8 Ovarian cancer in BRCA1 mutation carriers; LUSC cis rs11168618 0.904 rs7137866 chr12:48922802 T/C cg24011408 chr12:48396354 COL2A1 0.4 6.43 0.33 4.29e-10 Adiponectin levels; LUSC cis rs4704187 0.687 rs10035303 chr5:74505495 A/C cg03227963 chr5:74354835 NA 0.3 6.64 0.34 1.24e-10 Response to amphetamines; LUSC trans rs877282 0.947 rs957642 chr10:773966 C/T cg22713356 chr15:30763199 NA 1.09 15.83 0.65 1.75e-42 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10949322 chr10:35379230 CUL2 -0.4 -6.09 -0.32 3.13e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg03929089 chr4:120376271 NA -0.52 -7.29 -0.37 2.32e-12 HDL cholesterol; LUSC cis rs6845621 0.870 rs58618798 chr4:18905039 G/A cg12196642 chr4:18937545 NA -0.34 -6.46 -0.33 3.79e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg21361702 chr7:150065534 REPIN1 0.47 6.29 0.33 9.71e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs983392 0.679 rs10736701 chr11:60031476 C/T cg24026212 chr11:59952134 MS4A6A 0.36 6.32 0.33 8.42e-10 Alzheimer's disease (late onset); LUSC cis rs7818345 0.967 rs7015440 chr8:19276991 A/G cg11303988 chr8:19266685 CSGALNACT1 0.37 7.12 0.36 6.47e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.57 9.07 0.44 1.03e-17 Lymphocyte counts; LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg24829409 chr8:58192753 C8orf71 -0.59 -6.19 -0.32 1.78e-9 Developmental language disorder (linguistic errors); LUSC cis rs6977660 0.714 rs10260866 chr7:19793151 T/C cg05791153 chr7:19748676 TWISTNB 0.77 8.29 0.41 2.82e-15 Thyroid stimulating hormone; LUSC trans rs656319 0.559 rs55683917 chr8:9976479 C/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.96 -0.36 1.85e-11 Myopia (pathological); LUSC cis rs7173743 0.756 rs8035039 chr15:79129823 A/G cg00540400 chr15:79124168 NA 0.36 6.36 0.33 6.71e-10 Coronary artery disease; LUSC cis rs3768617 0.510 rs7525917 chr1:183065406 A/G ch.1.3577855R chr1:183094577 LAMC1 0.73 10.97 0.51 3.98e-24 Fuchs's corneal dystrophy; LUSC cis rs9457247 1.000 rs393558 chr6:167397750 A/C cg20406979 chr6:167373233 NA 0.26 6.13 0.32 2.5e-9 Crohn's disease; LUSC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg14298792 chr15:30685198 CHRFAM7A -0.65 -8.41 -0.42 1.17e-15 Huntington's disease progression; LUSC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg17971929 chr21:40555470 PSMG1 0.76 12.53 0.57 8.86e-30 Cognitive function; LUSC cis rs66887589 0.592 rs62320740 chr4:120279486 C/A cg24375607 chr4:120327624 NA 0.53 8.09 0.4 1.11e-14 Diastolic blood pressure; LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg25894440 chr7:65020034 NA 0.39 6.17 0.32 1.94e-9 Calcium levels; LUSC trans rs35110281 0.720 rs230647 chr21:44919654 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.62 -10.11 -0.48 3.93e-21 Mean corpuscular volume; LUSC cis rs17253792 0.915 rs76952651 chr14:56188994 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.14 -0.36 5.71e-12 Putamen volume; LUSC cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg05347473 chr6:146136440 FBXO30 0.55 9.49 0.46 4.62e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg27170947 chr2:26402098 FAM59B -0.65 -9.4 -0.46 9.24e-19 Gut microbiome composition (summer); LUSC cis rs11098499 0.575 rs9996586 chr4:120326942 A/G cg09307838 chr4:120376055 NA 0.46 6.9 0.35 2.54e-11 Corneal astigmatism; LUSC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg02782426 chr3:40428986 ENTPD3 0.42 7.93 0.4 3.34e-14 Renal cell carcinoma; LUSC cis rs2486288 0.656 rs7162022 chr15:45565253 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.73 -0.39 1.28e-13 Glomerular filtration rate; LUSC cis rs4619890 0.528 rs62289336 chr4:7877661 T/C cg24250820 chr4:7887609 AFAP1 0.36 6.15 0.32 2.17e-9 Glaucoma (primary open-angle); LUSC cis rs4077515 0.527 rs10870146 chr9:139308054 G/A cg14169450 chr9:139327907 INPP5E 0.45 8.06 0.4 1.33e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg00049323 chr5:472564 LOC25845 -0.43 -6.71 -0.34 8.18e-11 Cystic fibrosis severity; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12287025 chr11:44087605 ACCS -0.39 -5.96 -0.31 6.35e-9 Electrocardiographic conduction measures; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg08859206 chr1:53392774 SCP2 -0.54 -9.67 -0.47 1.17e-19 Monocyte count; LUSC cis rs977987 0.966 rs8055490 chr16:75497135 C/T cg04384234 chr16:75411784 CFDP1 -0.49 -8.14 -0.41 7.8e-15 Dupuytren's disease; LUSC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.47 -0.38 7.12e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg12311346 chr5:56204834 C5orf35 -0.78 -10.45 -0.5 2.75e-22 Initial pursuit acceleration; LUSC trans rs7937682 0.924 rs4630327 chr11:111539327 C/T cg18187862 chr3:45730750 SACM1L -0.55 -7.01 -0.36 1.29e-11 Primary sclerosing cholangitis; LUSC cis rs1048238 0.525 rs848214 chr1:16265422 A/G cg22431228 chr1:16359049 CLCNKA 0.4 8.4 0.42 1.33e-15 Systolic blood pressure; LUSC trans rs11098499 0.863 rs3775844 chr4:120428033 G/A cg25214090 chr10:38739885 LOC399744 0.5 7.39 0.37 1.19e-12 Corneal astigmatism; LUSC cis rs6456156 0.586 rs6456150 chr6:167468922 A/G cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs12618769 0.652 rs72823794 chr2:99216593 T/A cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg13206674 chr6:150067644 NUP43 0.62 10.05 0.48 6.38e-21 Lung cancer; LUSC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg11764359 chr7:65958608 NA 0.7 10.85 0.51 1.04e-23 Aortic root size; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg02475777 chr4:1388615 CRIPAK -0.4 -6.1 -0.32 3.01e-9 Obesity-related traits; LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -10.33 -0.49 7.12e-22 Platelet count; LUSC cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC cis rs28374715 0.532 rs28584379 chr15:41670408 C/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -22.83 -0.78 3.76e-70 Ulcerative colitis; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg01585723 chr16:33734837 NA 0.45 7.7 0.39 1.6e-13 Menopause (age at onset); LUSC cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.23 -0.45 3.12e-18 Monocyte percentage of white cells; LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.94 0.31 7.17e-9 Menopause (age at onset); LUSC cis rs7937682 0.889 rs558736 chr11:111500760 C/G cg09085632 chr11:111637200 PPP2R1B -1.1 -17.61 -0.69 1.4e-49 Primary sclerosing cholangitis; LUSC cis rs877282 0.583 rs11253441 chr10:828288 C/T cg13775593 chr10:823151 NA -0.3 -6.15 -0.32 2.17e-9 Uric acid levels; LUSC cis rs12681287 0.517 rs13249753 chr8:87513216 A/G cg27223183 chr8:87520930 FAM82B -0.57 -7.6 -0.38 2.99e-13 Caudate activity during reward; LUSC cis rs9467711 0.606 rs2073530 chr6:26375243 T/C cg09904177 chr6:26538194 HMGN4 -0.74 -6.95 -0.36 1.9e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9303280 0.901 rs7359623 chr17:38049589 C/T cg20243544 chr17:37824526 PNMT 0.43 6.48 0.33 3.25e-10 Self-reported allergy; LUSC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg25456477 chr12:86230367 RASSF9 -0.39 -7.02 -0.36 1.27e-11 Major depressive disorder; LUSC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.3 6.13 0.32 2.45e-9 Schizophrenia; LUSC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg19748678 chr4:122722346 EXOSC9 0.48 7.47 0.38 7.05e-13 Type 2 diabetes; LUSC cis rs136211 0.640 rs9306310 chr22:36758258 G/A cg16924664 chr22:36878180 TXN2 0.4 5.98 0.31 5.62e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4919087 0.923 rs11189037 chr10:98974707 C/G cg25902810 chr10:99078978 FRAT1 0.46 6.58 0.34 1.84e-10 Monocyte count; LUSC cis rs2607426 0.681 rs8109099 chr19:41282509 T/A cg05508168 chr19:41255947 C19orf54;SNRPA -0.9 -7.07 -0.36 9.1e-12 Blood protein levels; LUSC cis rs3770081 1.000 rs2278087 chr2:86281946 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC trans rs61931739 0.500 rs11615231 chr12:34413330 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.83 0.51 1.27e-23 Morning vs. evening chronotype; LUSC cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg07606381 chr6:8435919 SLC35B3 0.7 11.87 0.54 2.29e-27 Motion sickness; LUSC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg14019146 chr3:50243930 SLC38A3 -0.33 -7.35 -0.37 1.51e-12 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.818 rs1048296 chr1:153012240 A/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg25174290 chr11:3078921 CARS -0.59 -9.56 -0.46 2.67e-19 Longevity; LUSC cis rs354225 0.553 rs7564719 chr2:54829731 A/C cg01766943 chr2:54829624 SPTBN1 0.47 7.63 0.39 2.51e-13 Schizophrenia; LUSC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs600231 0.542 rs10896009 chr11:65246054 A/G cg17120908 chr11:65337727 SSSCA1 0.68 9.53 0.46 3.39e-19 Bone mineral density; LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg05313129 chr8:58192883 C8orf71 -0.51 -5.79 -0.3 1.64e-8 Developmental language disorder (linguistic errors); LUSC cis rs17029056 0.527 rs35490701 chr2:42158374 A/G cg25815440 chr2:42134162 NA 0.33 6.69 0.34 9.35e-11 Breast cancer; LUSC cis rs6547741 1.000 rs1919126 chr2:27801418 C/A cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 3.04e-39 Oral cavity cancer; LUSC cis rs3741151 0.656 rs73550316 chr11:73299799 G/A cg17517138 chr11:73019481 ARHGEF17 0.93 8.08 0.4 1.19e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4285028 0.948 rs12637351 chr3:121694412 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.72 9.33 0.45 1.57e-18 Multiple sclerosis; LUSC cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05792022 chr13:41239732 FOXO1 0.48 7.25 0.37 2.99e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9814567 1.000 rs4417907 chr3:134291363 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.85 -14.02 -0.61 1.89e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs8058578 0.832 rs3812999 chr16:30773605 G/T cg02466173 chr16:30829666 NA -0.6 -11.24 -0.52 4.47e-25 Multiple myeloma; LUSC cis rs939658 0.805 rs2010524 chr15:79435825 G/T cg17916960 chr15:79447300 NA -0.53 -10.67 -0.5 4.59e-23 Refractive error; LUSC cis rs7605827 0.836 rs13019322 chr2:15511270 G/A cg19274914 chr2:15703543 NA 0.46 8.95 0.44 2.45e-17 Educational attainment (years of education); LUSC cis rs7772486 0.846 rs2892453 chr6:146377717 C/A cg23711669 chr6:146136114 FBXO30 0.84 15.07 0.64 1.66e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg14196790 chr5:131705035 SLC22A5 0.48 8.18 0.41 6.2e-15 Blood metabolite levels; LUSC cis rs4356932 1.000 rs4535358 chr4:76974409 A/G cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg17252645 chr8:143867129 LY6D 0.38 6.68 0.34 1.01e-10 Urinary tract infection frequency; LUSC cis rs8014204 0.544 rs2286913 chr14:75386576 G/A cg08847533 chr14:75593920 NEK9 0.5 7.21 0.37 3.87e-12 Caffeine consumption; LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg14004847 chr7:1930337 MAD1L1 -0.56 -8.57 -0.42 3.77e-16 Bipolar disorder and schizophrenia; LUSC cis rs2115630 1.000 rs2115630 chr15:85364516 C/T cg09876464 chr15:85330779 ZNF592 0.36 6.56 0.34 2.06e-10 P wave terminal force; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg05025164 chr4:1340916 KIAA1530 0.63 10.06 0.48 5.51e-21 Longevity; LUSC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg02187348 chr16:89574699 SPG7 -0.6 -9.98 -0.48 1.05e-20 Multiple myeloma (IgH translocation); LUSC cis rs847577 0.588 rs12666406 chr7:97790991 G/A cg21770322 chr7:97807741 LMTK2 0.57 10.37 0.49 5.03e-22 Breast cancer; LUSC cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg03676636 chr4:99064102 C4orf37 0.37 8.1 0.4 1.08e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs12579753 0.917 rs11115029 chr12:82202219 C/G cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs10489202 1.000 rs34058770 chr1:168057399 C/A cg24449463 chr1:168025552 DCAF6 -0.58 -7.13 -0.36 6.4e-12 Schizophrenia; LUSC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg00049323 chr5:472564 LOC25845 -0.43 -6.71 -0.34 8.18e-11 Cystic fibrosis severity; LUSC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.19 -0.37 4.16e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs308403 0.509 rs1849431 chr4:123674762 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.94 16.05 0.66 2.3e-43 Blood protein levels; LUSC cis rs4820539 1.000 rs2157710 chr22:23457486 C/T cg14186256 chr22:23484241 RTDR1 0.94 17.06 0.68 2.19e-47 Bone mineral density; LUSC cis rs427394 0.659 rs274678 chr5:6752385 A/G cg10857441 chr5:6722123 POLS 0.44 8.12 0.41 8.97e-15 Menopause (age at onset); LUSC cis rs10189230 0.967 rs13026659 chr2:222353014 C/T cg14652038 chr2:222343519 EPHA4 0.34 6.0 0.31 5.23e-9 Urate levels in lean individuals; LUSC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg11632617 chr15:75315747 PPCDC -0.5 -6.58 -0.34 1.86e-10 Blood trace element (Zn levels); LUSC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg00677455 chr12:58241039 CTDSP2 0.61 8.48 0.42 7.56e-16 Multiple sclerosis; LUSC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.37 0.62 8.94e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg08499158 chr17:42289980 UBTF 0.42 6.38 0.33 6.04e-10 Total body bone mineral density; LUSC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg25811766 chr13:21894605 NA 0.63 7.78 0.39 9.04e-14 White matter hyperintensity burden; LUSC cis rs2742234 0.541 rs7098236 chr10:43740508 T/C cg02780029 chr10:43622663 RET 0.34 5.75 0.3 2.07e-8 Hirschsprung disease; LUSC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.76 -0.35 6.32e-11 Platelet count; LUSC cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg04545296 chr12:48745243 ZNF641 0.37 6.68 0.34 1.01e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg02574844 chr11:5959923 NA -0.4 -5.76 -0.3 1.95e-8 DNA methylation (variation); LUSC cis rs6733011 0.508 rs13004700 chr2:99527568 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.22 -0.32 1.52e-9 Bipolar disorder; LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18404041 chr3:52824283 ITIH1 -0.61 -11.94 -0.55 1.36e-27 Bipolar disorder; LUSC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg19717773 chr7:2847554 GNA12 -0.39 -6.07 -0.31 3.57e-9 Height; LUSC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg08132940 chr7:1081526 C7orf50 -0.48 -5.97 -0.31 6.16e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7769051 1.000 rs9493446 chr6:133125643 C/T cg22852734 chr6:133119734 C6orf192 1.17 14.03 0.61 1.8e-35 Type 2 diabetes nephropathy; LUSC cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg22618164 chr12:122356400 WDR66 0.6 8.97 0.44 2.13e-17 Mean corpuscular volume; LUSC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg12927641 chr6:109611667 NA -0.35 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs722599 0.715 rs12147629 chr14:75307588 A/G cg08847533 chr14:75593920 NEK9 -0.43 -6.07 -0.32 3.43e-9 IgG glycosylation; LUSC cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg23093090 chr10:104574429 C10orf26 -0.4 -6.79 -0.35 5.05e-11 Arsenic metabolism; LUSC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg11871910 chr12:69753446 YEATS4 0.82 14.42 0.62 5.7e-37 Blood protein levels; LUSC trans rs7647973 0.626 rs11709734 chr3:49745235 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -6.79 -0.35 5.19e-11 Menarche (age at onset); LUSC cis rs4595586 0.545 rs12828866 chr12:39391925 C/A cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs9325144 0.560 rs11183150 chr12:38674698 A/G cg13010199 chr12:38710504 ALG10B -0.51 -7.66 -0.39 2.03e-13 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs6488221 chr12:34525671 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs295140 0.903 rs3820888 chr2:201180023 T/C cg04283868 chr2:201171347 SPATS2L 0.41 6.15 0.32 2.27e-9 QT interval; LUSC cis rs9467773 1.000 rs1056667 chr6:26510564 T/C cg09904177 chr6:26538194 HMGN4 0.73 13.26 0.59 1.51e-32 Intelligence (multi-trait analysis); LUSC cis rs738322 0.934 rs133019 chr22:38573035 A/G cg17652424 chr22:38574118 PLA2G6 -0.31 -6.66 -0.34 1.1e-10 Cutaneous nevi; LUSC cis rs8061121 0.706 rs8048835 chr16:87188551 A/T cg10047845 chr16:87184939 NA 0.52 5.7 0.3 2.69e-8 Congenital left-sided heart lesions; LUSC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.4 -5.83 -0.3 1.3e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17854409 0.881 rs68066790 chr20:61487150 T/A cg05147244 chr20:61493195 TCFL5 0.95 7.5 0.38 6e-13 Obesity-related traits; LUSC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg00376283 chr12:123451042 ABCB9 0.7 9.84 0.47 3.03e-20 Neutrophil percentage of white cells; LUSC cis rs6546537 0.571 rs4852274 chr2:69780637 G/A cg10773587 chr2:69614142 GFPT1 -0.44 -6.92 -0.35 2.25e-11 Serum thyroid-stimulating hormone levels; LUSC cis rs4730250 0.707 rs257373 chr7:106798290 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.1 -0.45 8.66e-18 Osteoarthritis; LUSC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg23711669 chr6:146136114 FBXO30 0.83 15.19 0.64 5.29e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 0.900 rs6972027 chr7:91781380 T/C cg17063962 chr7:91808500 NA 0.6 9.54 0.46 3.18e-19 Breast cancer; LUSC trans rs7939886 0.920 rs17150038 chr11:55863414 A/T cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC trans rs11098499 0.955 rs1511019 chr4:120166007 T/G cg25214090 chr10:38739885 LOC399744 0.49 7.07 0.36 8.92e-12 Corneal astigmatism; LUSC trans rs6598955 0.585 rs6659822 chr1:26626408 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.66 -9.0 -0.44 1.77e-17 Obesity-related traits; LUSC cis rs1160297 0.585 rs12713230 chr2:53090138 A/G cg07782112 chr2:53107842 NA 0.4 6.44 0.33 4.27e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs2224391 1.000 rs2753248 chr6:5262154 G/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.72 -0.35 7.76e-11 Height; LUSC cis rs7954584 0.567 rs11043246 chr12:122368944 G/A cg01765077 chr12:122356316 WDR66 0.54 7.69 0.39 1.68e-13 Mean corpuscular volume; LUSC cis rs9905704 0.647 rs9898048 chr17:57108543 C/T cg05425664 chr17:57184151 TRIM37 -0.46 -7.07 -0.36 9.25e-12 Testicular germ cell tumor; LUSC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg07493874 chr5:1342172 CLPTM1L -0.27 -5.64 -0.3 3.54e-8 Lung cancer; LUSC cis rs7923609 0.967 rs10761758 chr10:65172747 A/T cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9388451 0.869 rs7764016 chr6:126070789 T/G cg10911889 chr6:126070802 HEY2 0.44 6.67 0.34 1.06e-10 Brugada syndrome; LUSC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg08270630 chr22:50330655 NA -0.42 -6.25 -0.32 1.25e-9 Schizophrenia; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg02951883 chr7:2050386 MAD1L1 -0.42 -7.2 -0.37 4.1e-12 Bipolar disorder and schizophrenia; LUSC cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg01579765 chr21:45077557 HSF2BP -0.54 -11.37 -0.53 1.57e-25 Mean corpuscular volume; LUSC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.13 -0.32 2.42e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3947 1.000 rs709821 chr8:11702594 G/C cg00262122 chr8:11665843 FDFT1 -0.47 -5.67 -0.3 3.08e-8 Blood protein levels; LUSC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg00033643 chr7:134001901 SLC35B4 0.44 6.73 0.35 7.57e-11 Mean platelet volume; LUSC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg22834771 chr12:69754056 YEATS4 -0.49 -7.33 -0.37 1.71e-12 Blood protein levels; LUSC cis rs868036 0.609 rs2045960 chr15:68092079 G/A cg24579218 chr15:68104479 NA -0.39 -6.51 -0.34 2.7e-10 Restless legs syndrome; LUSC cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC trans rs9393777 0.920 rs35120058 chr6:27358166 A/G cg01620082 chr3:125678407 NA -0.78 -6.87 -0.35 3.13e-11 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.517 rs11053224 chr12:34484919 G/A cg26384229 chr12:38710491 ALG10B 0.88 15.21 0.64 4.78e-40 Morning vs. evening chronotype; LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.25 0.37 3e-12 Platelet count; LUSC cis rs2070433 0.851 rs8129793 chr21:47925719 T/C cg12379764 chr21:47803548 PCNT 0.69 9.11 0.45 7.74e-18 Lymphocyte counts; LUSC cis rs6087990 0.806 rs6141814 chr20:31368960 C/A cg13636640 chr20:31349939 DNMT3B 0.89 17.61 0.69 1.43e-49 Ulcerative colitis; LUSC cis rs7215564 0.908 rs2316063 chr17:78663360 G/A cg23238734 chr17:78661607 RPTOR 0.47 6.1 0.32 2.98e-9 Myopia (pathological); LUSC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg24531977 chr5:56204891 C5orf35 -1.04 -15.37 -0.64 1.09e-40 Initial pursuit acceleration; LUSC cis rs870825 0.616 rs6552802 chr4:185620751 C/G cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs3768617 0.811 rs4350171 chr1:182982148 C/T ch.1.3577855R chr1:183094577 LAMC1 0.59 8.42 0.42 1.12e-15 Fuchs's corneal dystrophy; LUSC cis rs7944735 0.508 rs4752877 chr11:47886165 C/A cg20307385 chr11:47447363 PSMC3 -0.55 -5.67 -0.3 3.06e-8 Intraocular pressure; LUSC cis rs8040855 0.627 rs1532776 chr15:85624614 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.41 -5.92 -0.31 8.12e-9 Bulimia nervosa; LUSC trans rs877282 0.891 rs34652870 chr10:772218 T/C cg13042288 chr15:90349979 ANPEP -0.49 -6.82 -0.35 4.39e-11 Uric acid levels; LUSC cis rs4891159 0.757 rs11665018 chr18:74123589 C/T cg24786174 chr18:74118243 ZNF516 -0.83 -15.31 -0.64 1.87e-40 Longevity; LUSC trans rs2832191 0.716 rs2692625 chr21:30446360 C/G cg14791747 chr16:20752902 THUMPD1 -0.4 -6.14 -0.32 2.33e-9 Dental caries; LUSC cis rs11650494 0.908 rs11658111 chr17:47383994 C/T cg08112188 chr17:47440006 ZNF652 1.17 10.21 0.49 1.71e-21 Prostate cancer; LUSC cis rs9788682 0.948 rs59133824 chr15:78833450 C/A cg06917634 chr15:78832804 PSMA4 -0.59 -7.25 -0.37 2.85e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.17e-20 Major depressive disorder; LUSC cis rs10823500 0.545 rs7082562 chr10:71945684 A/G cg26699283 chr10:71892715 AIFM2 -0.36 -5.7 -0.3 2.7e-8 Blood protein levels; LUSC cis rs11264799 0.765 rs67070092 chr1:157622973 T/A cg18268488 chr1:157545234 FCRL4 0.33 5.74 0.3 2.13e-8 IgA nephropathy; LUSC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg00745463 chr17:30367425 LRRC37B -0.79 -9.21 -0.45 3.67e-18 Hip circumference adjusted for BMI; LUSC trans rs2204008 0.837 rs11180821 chr12:38242843 A/G cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.73e-9 Bladder cancer; LUSC cis rs6714710 0.603 rs7421146 chr2:98552271 G/C cg26665480 chr2:98280029 ACTR1B 0.63 9.11 0.45 7.76e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg03161606 chr19:29218774 NA 0.6 8.84 0.44 5.41e-17 Methadone dose in opioid dependence; LUSC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.78 -0.35 5.6e-11 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg26597838 chr10:835615 NA 1.22 16.53 0.67 2.92e-45 Eosinophil percentage of granulocytes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04000159 chr8:54755598 ATP6V1H 0.48 7.32 0.37 1.83e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg11645453 chr3:52864694 ITIH4 0.37 8.66 0.43 2.06e-16 Bipolar disorder; LUSC trans rs9291683 0.632 rs13101785 chr4:10042915 T/A cg26043149 chr18:55253948 FECH 0.49 7.24 0.37 3.02e-12 Bone mineral density; LUSC cis rs1953600 0.870 rs1049550 chr10:81926702 G/A cg00277334 chr10:82204260 NA -0.44 -6.92 -0.35 2.36e-11 Sarcoidosis; LUSC trans rs7618501 0.633 rs4688758 chr3:50028385 G/A cg21659725 chr3:3221576 CRBN 0.62 10.21 0.49 1.78e-21 Intelligence (multi-trait analysis); LUSC cis rs2073300 0.609 rs6137915 chr20:23358509 A/G cg09953122 chr20:23471693 CST8 0.65 5.92 0.31 8.07e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7527798 0.592 rs10863437 chr1:207817612 T/C cg09232269 chr1:207846808 CR1L -0.3 -6.38 -0.33 5.88e-10 Erythrocyte sedimentation rate; LUSC cis rs11098499 0.754 rs1511017 chr4:120250805 G/A cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs11785400 0.793 rs2976400 chr8:143743611 G/A cg10596483 chr8:143751796 JRK 0.52 7.46 0.38 7.78e-13 Schizophrenia; LUSC cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg25456477 chr12:86230367 RASSF9 0.4 6.91 0.35 2.45e-11 Major depressive disorder; LUSC cis rs6545883 0.826 rs777590 chr2:61417145 C/G cg15711740 chr2:61764176 XPO1 -0.43 -6.68 -0.34 1.03e-10 Tuberculosis; LUSC cis rs9633740 1.000 rs7922621 chr10:82251544 C/A cg01528321 chr10:82214614 TSPAN14 1.1 12.06 0.55 4.95e-28 Post bronchodilator FEV1; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg26354017 chr1:205819088 PM20D1 0.45 7.09 0.36 8.18e-12 Menarche (age at onset); LUSC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg18099408 chr3:52552593 STAB1 -0.36 -6.29 -0.33 9.97e-10 Electroencephalogram traits; LUSC cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs7917772 0.582 rs4919665 chr10:104366042 C/T cg22532475 chr10:104410764 TRIM8 0.25 6.05 0.31 3.85e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.51 0.53 4.93e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7267979 1.000 rs6115159 chr20:25350944 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.34 -0.74 2.17e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg20243544 chr17:37824526 PNMT -0.46 -5.67 -0.3 3.1e-8 Glomerular filtration rate (creatinine); LUSC cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg15744005 chr10:104629667 AS3MT -0.32 -6.19 -0.32 1.75e-9 Arsenic metabolism; LUSC cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg08975724 chr8:8085496 FLJ10661 0.52 7.96 0.4 2.74e-14 Mood instability; LUSC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg25754956 chr12:51612065 POU6F1 0.98 13.47 0.59 2.48e-33 Cisplatin-induced ototoxicity; LUSC cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg20887711 chr4:1340912 KIAA1530 0.41 6.26 0.32 1.18e-9 Obesity-related traits; LUSC cis rs782590 0.902 rs782602 chr2:55849309 A/G cg18811423 chr2:55921094 PNPT1 0.78 13.51 0.59 1.7e-33 Metabolic syndrome; LUSC cis rs3008870 1.000 rs12044278 chr1:67460977 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs11690935 0.595 rs788171 chr2:172921832 A/G cg13550731 chr2:172543902 DYNC1I2 0.57 9.35 0.46 1.27e-18 Schizophrenia; LUSC cis rs61931739 0.782 rs7969373 chr12:34249655 T/G cg06521331 chr12:34319734 NA -0.4 -6.81 -0.35 4.54e-11 Morning vs. evening chronotype; LUSC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.69e-9 Aortic root size; LUSC trans rs11098499 0.820 rs28578366 chr4:120536905 A/G cg25214090 chr10:38739885 LOC399744 -0.5 -7.71 -0.39 1.45e-13 Corneal astigmatism; LUSC cis rs1003719 0.680 rs2187577 chr21:38533341 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.29 -0.49 9.26e-22 Eye color traits; LUSC cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg18681998 chr4:17616180 MED28 0.84 15.51 0.65 3.01e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6964587 1.000 rs7811873 chr7:91751120 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.83 0.3 1.34e-8 Breast cancer; LUSC cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14019695 chr9:139328340 INPP5E -0.5 -10.08 -0.48 5.05e-21 Granulocyte percentage of myeloid white cells; LUSC trans rs11098499 0.954 rs6838814 chr4:120392443 G/A cg25214090 chr10:38739885 LOC399744 0.58 8.47 0.42 8.08e-16 Corneal astigmatism; LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg05025164 chr4:1340916 KIAA1530 0.46 7.06 0.36 9.77e-12 Obesity-related traits; LUSC cis rs6700896 0.864 rs6588153 chr1:66092017 T/A cg04111102 chr1:66153794 NA 0.32 7.01 0.36 1.29e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02453779 chr11:105948520 AASDHPPT;KBTBD3 -0.49 -6.19 -0.32 1.79e-9 Bipolar disorder and schizophrenia; LUSC cis rs11792861 0.816 rs28361111 chr9:111761012 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.55 7.92 0.4 3.59e-14 Menarche (age at onset); LUSC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs765787 0.530 rs4775835 chr15:45537553 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC trans rs6601327 0.518 rs13264850 chr8:9575331 A/T cg15556689 chr8:8085844 FLJ10661 -0.44 -6.29 -0.33 1e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs3812049 0.737 rs1112956 chr5:127433798 C/T cg16011800 chr17:1958478 HIC1 0.43 6.02 0.31 4.66e-9 Lymphocyte counts;Red cell distribution width; LUSC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg18512352 chr11:47633146 NA -0.47 -9.72 -0.47 7.72e-20 Subjective well-being; LUSC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg08975724 chr8:8085496 FLJ10661 0.41 6.03 0.31 4.24e-9 Retinal vascular caliber; LUSC cis rs11122272 0.735 rs2739513 chr1:231515201 C/T cg06096015 chr1:231504339 EGLN1 0.56 9.98 0.48 1.07e-20 Hemoglobin concentration; LUSC cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg08477640 chr19:41863820 B9D2 0.5 7.65 0.39 2.13e-13 Migraine;Coronary artery disease; LUSC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg08859206 chr1:53392774 SCP2 -0.42 -6.74 -0.35 6.96e-11 Monocyte count; LUSC cis rs11098499 0.954 rs12505469 chr4:120249585 C/T cg24375607 chr4:120327624 NA 0.79 11.85 0.54 2.9e-27 Corneal astigmatism; LUSC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs6500602 0.702 rs2058812 chr16:4524443 C/G cg08645402 chr16:4508243 NA 0.53 9.05 0.44 1.17e-17 Schizophrenia; LUSC cis rs4900538 0.855 rs12587464 chr14:102886561 G/C cg18135206 chr14:102964638 TECPR2 -0.98 -18.71 -0.72 6.21e-54 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7759001 0.857 rs10080569 chr6:27363076 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.67 0.3 3.1e-8 Glomerular filtration rate (creatinine); LUSC cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg04034577 chr2:241836375 C2orf54 -0.48 -8.93 -0.44 2.94e-17 Urinary metabolites; LUSC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg18876405 chr7:65276391 NA 0.76 13.54 0.6 1.34e-33 Aortic root size; LUSC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg14829155 chr15:31115871 NA -0.57 -7.9 -0.4 4e-14 Huntington's disease progression; LUSC cis rs7666738 0.546 rs1813970 chr4:98887167 A/G cg05340658 chr4:99064831 C4orf37 -0.57 -8.97 -0.44 2.17e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg18230493 chr5:56204884 C5orf35 -0.6 -9.38 -0.46 1.03e-18 Coronary artery disease; LUSC trans rs62103177 0.810 rs62103189 chr18:77627815 G/A cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg14552801 chr7:65878734 NA 0.38 5.76 0.3 1.96e-8 Aortic root size; LUSC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -16.24 -0.66 4.09e-44 Prostate cancer; LUSC cis rs2197308 0.692 rs7488528 chr12:37912971 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.7 0.65 5.43e-42 Morning vs. evening chronotype; LUSC cis rs6494488 0.500 rs72744734 chr15:65042312 C/A cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs9790314 1.000 rs1382428 chr3:161032386 A/C cg03342759 chr3:160939853 NMD3 -0.49 -8.16 -0.41 6.68e-15 Morning vs. evening chronotype; LUSC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg08213375 chr14:104286397 PPP1R13B 0.42 7.11 0.36 7.04e-12 Reticulocyte count; LUSC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg08847533 chr14:75593920 NEK9 -0.84 -15.37 -0.64 1.1e-40 Height; LUSC cis rs2742417 0.603 rs2742449 chr3:45764544 T/C cg10512202 chr3:45649293 LIMD1 0.35 5.88 0.31 9.96e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10740039 0.516 rs10740032 chr10:62322385 C/T cg18175470 chr10:62150864 ANK3 -0.45 -6.89 -0.35 2.87e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.63 9.56 0.46 2.7e-19 Menarche (age at onset); LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg25767906 chr1:53392781 SCP2 -0.5 -9.11 -0.45 7.51e-18 Monocyte count; LUSC cis rs11098499 0.863 rs7678400 chr4:120461957 G/A cg24375607 chr4:120327624 NA 0.76 11.19 0.52 6.99e-25 Corneal astigmatism; LUSC cis rs11971779 0.715 rs6954219 chr7:139065110 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03352830 chr11:487213 PTDSS2 0.68 8.54 0.42 4.67e-16 Body mass index; LUSC cis rs34734847 0.787 rs7976497 chr12:121135467 T/C cg27246729 chr12:121163418 ACADS 0.42 6.71 0.34 8.13e-11 Mean corpuscular volume; LUSC trans rs9929218 1.000 rs12921546 chr16:68780069 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -12.35 -0.56 3.9e-29 Colorectal cancer; LUSC cis rs9300255 0.544 rs2049114 chr12:123657338 T/C cg13010344 chr12:123464640 ARL6IP4 -0.47 -6.36 -0.33 6.49e-10 Neutrophil percentage of white cells; LUSC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg00677455 chr12:58241039 CTDSP2 0.61 8.57 0.42 3.9e-16 Multiple sclerosis; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 6.15 0.32 2.2e-9 Electroencephalogram traits; LUSC cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg13385521 chr17:29058706 SUZ12P 0.6 5.86 0.31 1.09e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs734999 0.545 rs4648565 chr1:2570023 A/G cg18854424 chr1:2615690 NA -0.5 -9.71 -0.47 8.48e-20 Ulcerative colitis; LUSC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg11645453 chr3:52864694 ITIH4 0.34 8.08 0.4 1.23e-14 Electroencephalogram traits; LUSC cis rs9527 0.615 rs7089065 chr10:104723022 C/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.68 -0.34 1e-10 Arsenic metabolism; LUSC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg09826364 chr7:158789723 NA -0.38 -5.98 -0.31 5.83e-9 Facial morphology (factor 20); LUSC trans rs7765175 0.598 rs1388219 chr6:113620699 C/T cg03745386 chr12:29534188 ERGIC2 -0.38 -6.0 -0.31 5.24e-9 Coronary artery calcification; LUSC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.43 0.5 3.23e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg25767906 chr1:53392781 SCP2 -0.62 -11.99 -0.55 8.4e-28 Monocyte count; LUSC cis rs7666738 0.546 rs2098935 chr4:98914376 A/G cg03676636 chr4:99064102 C4orf37 0.3 6.11 0.32 2.75e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1476679 0.927 rs2405442 chr7:99971313 T/C cg19116668 chr7:99932089 PMS2L1 0.44 7.82 0.39 6.95e-14 Alzheimer's disease (late onset); LUSC cis rs1005224 0.853 rs6574251 chr14:76136883 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.66 -9.06 -0.44 1.16e-17 Large artery stroke; LUSC cis rs6754311 0.773 rs309125 chr2:136643555 C/T cg07169764 chr2:136633963 MCM6 0.54 7.29 0.37 2.21e-12 Mosquito bite size; LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg00166722 chr3:10149974 C3orf24 0.64 8.8 0.43 7.45e-17 Alzheimer's disease; LUSC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.4 -0.33 5.3e-10 Prostate cancer (SNP x SNP interaction); LUSC trans rs7829975 0.573 rs7842359 chr8:8797078 T/G cg27411982 chr8:10470053 RP1L1 -0.39 -6.38 -0.33 5.91e-10 Mood instability; LUSC cis rs16895831 0.519 rs4379287 chr6:42592486 T/C cg10605015 chr6:42532144 UBR2 0.48 5.69 0.3 2.85e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs477692 0.699 rs557311 chr10:131389484 A/G cg11019008 chr10:131425282 MGMT 0.41 5.91 0.31 8.46e-9 Response to temozolomide; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg23131131 chr22:24373011 LOC391322 -0.49 -7.07 -0.36 8.9e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11148252 0.500 rs342768 chr13:53208882 C/T cg00495681 chr13:53174319 NA 0.77 14.43 0.62 4.87e-37 Lewy body disease; LUSC cis rs35883536 0.647 rs1855630 chr1:101039979 C/G cg06223162 chr1:101003688 GPR88 -0.47 -8.88 -0.44 4.3e-17 Monocyte count; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.03 -0.4 1.71e-14 Lymphocyte counts; LUSC cis rs6690583 1.000 rs6690464 chr1:85466369 A/G cg11262906 chr1:85462892 MCOLN2 -0.73 -9.25 -0.45 2.68e-18 Serum sulfate level; LUSC cis rs11190604 0.767 rs11190520 chr10:102175309 T/C cg07080220 chr10:102295463 HIF1AN 0.6 7.64 0.39 2.38e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3820068 0.506 rs17448966 chr1:15990983 T/G cg24675056 chr1:15929824 NA 0.43 7.6 0.38 3.02e-13 Systolic blood pressure; LUSC cis rs612683 0.602 rs2030048 chr1:101006577 C/T cg06223162 chr1:101003688 GPR88 -0.51 -9.5 -0.46 4.14e-19 Breast cancer; LUSC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg26597838 chr10:835615 NA 0.81 11.31 0.53 2.58e-25 Eosinophil percentage of granulocytes; LUSC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.58 -9.18 -0.45 4.78e-18 Total body bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06434480 chr5:74632940 HMGCR 0.47 6.43 0.33 4.39e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg14829155 chr15:31115871 NA 0.45 6.27 0.32 1.09e-9 Huntington's disease progression; LUSC cis rs4722585 0.533 rs3753097 chr7:26198207 A/G cg07876897 chr7:26191696 NFE2L3 0.46 6.9 0.35 2.62e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs11098499 0.863 rs1383533 chr4:120434576 G/A cg24375607 chr4:120327624 NA 0.75 11.26 0.52 3.74e-25 Corneal astigmatism; LUSC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg21644426 chr2:191273491 MFSD6 0.61 9.65 0.47 1.36e-19 Pulse pressure; LUSC cis rs4718428 0.705 rs10267335 chr7:66403220 G/T cg18252515 chr7:66147081 NA -0.58 -7.98 -0.4 2.31e-14 Corneal structure; LUSC cis rs1775715 0.769 rs2808102 chr10:32117749 A/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.58 0.34 1.8e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg02569458 chr12:86230093 RASSF9 0.55 9.21 0.45 3.79e-18 Major depressive disorder; LUSC cis rs6430585 0.528 rs499483 chr2:136652524 G/A cg07169764 chr2:136633963 MCM6 1.18 17.44 0.69 6.88e-49 Corneal structure; LUSC cis rs2354432 0.607 rs6694347 chr1:146751140 T/C cg25205988 chr1:146714368 CHD1L -1.0 -9.35 -0.46 1.26e-18 Mitochondrial DNA levels; LUSC cis rs2688419 0.545 rs6550719 chr3:23072185 C/G cg00327796 chr3:23032191 NA -0.42 -7.35 -0.37 1.53e-12 Type 2 diabetes; LUSC trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg15704280 chr7:45808275 SEPT13 0.88 12.64 0.57 3.48e-30 Coronary artery disease; LUSC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg17971929 chr21:40555470 PSMG1 -0.68 -11.26 -0.52 3.79e-25 Cognitive function; LUSC trans rs561341 0.882 rs111484028 chr17:30287701 G/A cg20587970 chr11:113659929 NA -1.11 -15.3 -0.64 1.99e-40 Hip circumference adjusted for BMI; LUSC cis rs9296092 0.538 rs75652975 chr6:33516251 C/T cg13560919 chr6:33536144 NA -0.82 -15.66 -0.65 7.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg26668828 chr6:292823 DUSP22 -0.54 -8.18 -0.41 5.92e-15 Menopause (age at onset); LUSC cis rs6060717 0.654 rs8122716 chr20:34607001 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -5.74 -0.3 2.16e-8 Hip circumference adjusted for BMI; LUSC cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg05347473 chr6:146136440 FBXO30 0.54 9.25 0.45 2.77e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg13944838 chr5:179740914 GFPT2 0.64 10.53 0.5 1.45e-22 Height; LUSC cis rs4930103 0.590 rs3809101 chr11:1967271 C/T cg23202291 chr11:1979235 NA 0.41 6.66 0.34 1.11e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Metabolite levels (small molecules and protein measures); LUSC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg17376030 chr22:41985996 PMM1 -0.48 -5.9 -0.31 8.71e-9 Vitiligo; LUSC cis rs9677476 0.863 rs12478335 chr2:232064967 C/A cg07929768 chr2:232055508 NA 0.37 7.0 0.36 1.41e-11 Food antigen IgG levels; LUSC trans rs7618501 0.633 rs2526748 chr3:50080439 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.55 -8.94 -0.44 2.75e-17 Intelligence (multi-trait analysis); LUSC cis rs2004776 0.656 rs11122587 chr1:230867100 C/G cg07502417 chr1:230849801 AGT 0.25 5.77 0.3 1.85e-8 Diastolic blood pressure; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg07092213 chr7:1199455 ZFAND2A -0.67 -11.22 -0.52 5.24e-25 Longevity;Endometriosis; LUSC cis rs2404602 0.692 rs12437733 chr15:77155562 A/G cg23625390 chr15:77176239 SCAPER 0.46 6.83 0.35 3.92e-11 Blood metabolite levels; LUSC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12756686 chr19:29218302 NA 0.67 9.54 0.46 3.15e-19 Methadone dose in opioid dependence; LUSC cis rs1577917 0.917 rs2197651 chr6:86495442 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.16 -0.36 5.15e-12 Response to antipsychotic treatment; LUSC cis rs6138458 1.000 rs6114981 chr20:24974401 C/T cg06937882 chr20:24974362 C20orf3 0.45 7.86 0.4 5.28e-14 Blood protein levels; LUSC cis rs9650657 0.836 rs6601523 chr8:10635141 C/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.76 -0.3 1.96e-8 Neuroticism; LUSC cis rs968567 0.705 rs174573 chr11:61600327 G/A cg06781209 chr11:61594997 FADS2 -0.42 -6.73 -0.35 7.29e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg16240275 chr20:61666158 NCRNA00029 0.41 9.08 0.45 9.54e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6964587 1.000 rs6952389 chr7:91657994 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.6e-8 Breast cancer; LUSC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.58 0.38 3.44e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs4595586 0.525 rs1400279 chr12:39343825 T/A cg13010199 chr12:38710504 ALG10B 0.46 6.49 0.33 3.11e-10 Morning vs. evening chronotype; LUSC cis rs62027291 0.583 rs62027297 chr15:77281674 A/T cg26408565 chr15:76604113 ETFA 0.44 5.96 0.31 6.45e-9 Plateletcrit; LUSC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.67 0.54 1.23e-26 Hip circumference adjusted for BMI; LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.77 -0.39 9.55e-14 Height; LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg24829409 chr8:58192753 C8orf71 -0.59 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs4711103 chr6:25742224 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs3782089 1.000 rs3782089 chr11:65336819 C/T cg08676812 chr11:65308423 LTBP3 0.94 6.57 0.34 1.89e-10 Height; LUSC cis rs12137294 0.866 rs1172156 chr1:205220087 C/T cg00857998 chr1:205179979 DSTYK 0.4 5.86 0.31 1.13e-8 Red cell distribution width; LUSC cis rs68170813 0.605 rs75659533 chr7:107134987 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.21 -0.45 3.77e-18 Coronary artery disease; LUSC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg05340658 chr4:99064831 C4orf37 0.64 11.18 0.52 7.59e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7809950 1.000 rs2293658 chr7:107270567 C/T cg23024343 chr7:107201750 COG5 -0.55 -8.84 -0.44 5.52e-17 Coronary artery disease; LUSC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg21918786 chr6:109611834 NA -0.36 -6.19 -0.32 1.8e-9 Reticulocyte fraction of red cells; LUSC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg01879757 chr17:41196368 BRCA1 -0.46 -7.0 -0.36 1.44e-11 Menopause (age at onset); LUSC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg18252515 chr7:66147081 NA -1.21 -13.94 -0.61 4.07e-35 Diabetic kidney disease; LUSC cis rs1355223 0.573 rs7125773 chr11:34723573 A/G cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.55 -0.34 2.12e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg10792982 chr14:105748885 BRF1 0.45 8.08 0.4 1.19e-14 Mean platelet volume;Platelet distribution width; LUSC trans rs35110281 0.715 rs969060 chr21:45080852 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.33 0.53 2.1e-25 Mean corpuscular volume; LUSC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg10792982 chr14:105748885 BRF1 0.52 9.42 0.46 7.45e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs7113850 0.541 rs7107667 chr11:24224091 T/A ch.11.24196551F chr11:24239977 NA 1.0 8.93 0.44 2.94e-17 Bone fracture in osteoporosis; LUSC cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs2652834 0.898 rs10162675 chr15:63370358 T/C cg05507819 chr15:63340323 TPM1 -0.67 -8.06 -0.4 1.35e-14 HDL cholesterol; LUSC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg22875332 chr1:76189707 ACADM 0.76 10.84 0.51 1.13e-23 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs877282 0.898 rs12357016 chr10:765675 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.41 -0.33 4.97e-10 Uric acid levels; LUSC cis rs71636778 0.543 rs17162330 chr1:27236212 A/G cg12203394 chr1:27248618 NUDC 0.54 5.71 0.3 2.52e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -6.04 -0.31 4.03e-9 Intelligence (multi-trait analysis); LUSC trans rs7937682 0.961 rs491937 chr11:111494947 A/T cg18187862 chr3:45730750 SACM1L 0.54 7.06 0.36 9.6e-12 Primary sclerosing cholangitis; LUSC cis rs40363 1.000 rs37769 chr16:3514580 C/G cg21433313 chr16:3507492 NAT15 0.79 9.94 0.48 1.41e-20 Tuberculosis; LUSC cis rs2239547 0.563 rs6445547 chr3:52908577 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.42 5.93 0.31 7.49e-9 Schizophrenia; LUSC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg13944838 chr5:179740914 GFPT2 -0.64 -10.12 -0.48 3.65e-21 Height; LUSC cis rs6489882 0.867 rs7298184 chr12:113368249 C/A cg20102336 chr12:113376681 OAS3 -0.42 -6.13 -0.32 2.44e-9 Chronic lymphocytic leukemia; LUSC cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.97 -0.4 2.54e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg02569458 chr12:86230093 RASSF9 0.58 9.91 0.48 1.9e-20 Major depressive disorder; LUSC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg18230493 chr5:56204884 C5orf35 0.64 10.66 0.5 5.13e-23 Initial pursuit acceleration; LUSC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg03806693 chr22:41940476 POLR3H 0.88 12.29 0.56 7.03e-29 Vitiligo; LUSC cis rs1044826 0.642 rs4683464 chr3:139196961 C/T cg00490450 chr3:139108681 COPB2 0.46 6.99 0.36 1.5e-11 Obesity-related traits; LUSC trans rs961253 0.556 rs6054140 chr20:6331643 A/G cg17788362 chr6:86352627 SYNCRIP 0.41 5.98 0.31 5.82e-9 Colorectal cancer; LUSC cis rs2742417 0.967 rs2742462 chr3:45774696 G/A cg04837898 chr3:45731254 SACM1L -0.38 -6.41 -0.33 4.88e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.89 -0.31 9.46e-9 Tonsillectomy; LUSC cis rs1775715 0.870 rs7095322 chr10:32248491 C/T cg04359828 chr10:32216031 ARHGAP12 -0.39 -6.62 -0.34 1.45e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11229555 0.645 rs11229459 chr11:58208025 G/A cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6500395 0.928 rs2080509 chr16:48690915 T/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg05738196 chr6:26577821 NA -0.48 -7.06 -0.36 9.54e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg19678392 chr7:94953810 PON1 -0.35 -5.65 -0.3 3.36e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg02423579 chr7:2872169 GNA12 -0.4 -6.39 -0.33 5.45e-10 Height; LUSC cis rs4654899 0.802 rs6685306 chr1:21219050 C/T cg01072550 chr1:21505969 NA -0.52 -7.59 -0.38 3.15e-13 Superior frontal gyrus grey matter volume; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg14004847 chr7:1930337 MAD1L1 -0.54 -8.12 -0.41 9.3e-15 Bipolar disorder and schizophrenia; LUSC cis rs1729951 0.575 rs168635 chr3:136699078 A/G cg12473912 chr3:136751656 NA 0.38 6.83 0.35 3.97e-11 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21611145 chr19:13261629 IER2;STX10 0.46 7.19 0.37 4.19e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1595825 0.732 rs77615390 chr2:198454790 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.36 -0.33 6.8e-10 Ulcerative colitis; LUSC cis rs9325144 0.577 rs10876008 chr12:39126750 T/C cg13010199 chr12:38710504 ALG10B -0.49 -7.47 -0.38 6.91e-13 Morning vs. evening chronotype; LUSC trans rs62103177 0.673 rs62096717 chr18:77616819 C/T cg14227996 chr4:17616232 MED28 0.57 6.4 0.33 5.22e-10 Opioid sensitivity; LUSC cis rs1801251 1.000 rs13013142 chr2:233600606 A/G cg25237894 chr2:233734115 C2orf82 0.34 6.38 0.33 6.03e-10 Coronary artery disease; LUSC trans rs1922233 0.891 rs28508157 chr4:92410988 C/T cg24250684 chr1:219729030 NA -0.33 -6.42 -0.33 4.69e-10 Gut microbiome composition (summer and winter); LUSC cis rs25645 0.502 rs7207600 chr17:38091660 G/A cg26162295 chr17:38119207 GSDMA -0.29 -6.53 -0.34 2.43e-10 Myeloid white cell count; LUSC trans rs61931739 0.749 rs11053093 chr12:34231095 A/G cg26384229 chr12:38710491 ALG10B 0.54 8.71 0.43 1.46e-16 Morning vs. evening chronotype; LUSC cis rs55882075 0.690 rs12374485 chr5:179131395 G/C cg14593053 chr5:179126677 CANX 0.49 7.88 0.4 4.7e-14 Monocyte percentage of white cells; LUSC cis rs10761482 0.813 rs2061489 chr10:62103196 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.1 0.41 1.01e-14 Homoarginine levels; LUSC cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg21535247 chr6:8435926 SLC35B3 0.57 8.7 0.43 1.48e-16 Motion sickness; LUSC trans rs1997103 0.906 rs2177806 chr7:55402609 A/T cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6545883 0.791 rs2600665 chr2:61405795 G/T cg15711740 chr2:61764176 XPO1 -0.4 -5.97 -0.31 6.2e-9 Tuberculosis; LUSC cis rs12291225 0.679 rs11238 chr11:14288128 A/C cg05501817 chr11:14380813 RRAS2 0.56 8.76 0.43 9.7e-17 Sense of smell; LUSC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg14829155 chr15:31115871 NA 0.46 6.67 0.34 1.07e-10 Huntington's disease progression; LUSC cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg12923728 chr3:195709715 SDHAP1 -0.79 -12.42 -0.56 2.15e-29 Pancreatic cancer; LUSC cis rs9300255 0.602 rs1402274 chr12:123686224 T/C cg00376283 chr12:123451042 ABCB9 0.64 8.15 0.41 7.56e-15 Neutrophil percentage of white cells; LUSC trans rs9960767 0.803 rs10401120 chr18:53192498 A/G cg26244646 chr17:59391924 BCAS3 -0.51 -6.16 -0.32 2.1e-9 Schizophrenia; LUSC cis rs1775715 0.677 rs2808105 chr10:32110907 C/T cg03015672 chr10:32216066 ARHGAP12 0.33 5.84 0.3 1.22e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs57590327 0.503 rs2372905 chr3:81504592 C/G cg07356753 chr3:81810745 GBE1 0.44 5.85 0.31 1.15e-8 Extraversion; LUSC cis rs9879311 0.966 rs6442165 chr3:10415108 A/C cg08489410 chr3:10329245 GHRL;GHRLOS 0.44 7.06 0.36 9.55e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg11861562 chr11:117069780 TAGLN 0.34 6.59 0.34 1.75e-10 Blood protein levels; LUSC cis rs939658 0.935 rs2204069 chr15:79449335 A/G cg17916960 chr15:79447300 NA 0.49 9.95 0.48 1.39e-20 Refractive error; LUSC cis rs2446066 0.799 rs76805893 chr12:53830119 G/C cg20730629 chr12:53886622 MAP3K12 -0.42 -5.72 -0.3 2.4e-8 Red blood cell count; LUSC trans rs1325195 0.537 rs1325194 chr1:179071918 G/T cg11624085 chr17:8464688 MYH10 -0.44 -6.59 -0.34 1.71e-10 IgE grass sensitization; LUSC trans rs853679 1.000 rs2799077 chr6:28234597 C/T cg06606381 chr12:133084897 FBRSL1 -0.58 -6.71 -0.34 8.43e-11 Depression; LUSC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.44 0.65 5.6e-41 Intelligence (multi-trait analysis); LUSC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg11645453 chr3:52864694 ITIH4 0.33 7.83 0.39 6.46e-14 Electroencephalogram traits; LUSC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg19230755 chr7:65878503 NA -0.41 -5.75 -0.3 2e-8 Aortic root size; LUSC cis rs4363385 0.747 rs1577964 chr1:152961784 C/A cg00922841 chr1:152955080 SPRR1A -0.42 -7.31 -0.37 1.95e-12 Inflammatory skin disease; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg22903657 chr4:1355424 KIAA1530 -0.36 -6.02 -0.31 4.68e-9 Obesity-related traits; LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.779 rs12210620 chr6:25884785 T/C cg16482183 chr6:26056742 HIST1H1C 0.87 11.64 0.54 1.66e-26 Iron status biomarkers; LUSC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.66 5.85 0.31 1.14e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs763121 0.776 rs5757177 chr22:39007174 A/C cg06022373 chr22:39101656 GTPBP1 0.83 13.39 0.59 5.01e-33 Menopause (age at onset); LUSC cis rs1152591 0.562 rs1262242 chr14:64653869 C/T cg21174375 chr14:64681225 SYNE2 0.34 6.18 0.32 1.86e-9 Atrial fibrillation; LUSC cis rs4423214 0.959 rs12793224 chr11:71168710 G/A cg05163923 chr11:71159392 DHCR7 0.74 10.98 0.52 3.66e-24 Vitamin D levels; LUSC cis rs9393777 0.528 rs9467989 chr6:27064275 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.44 -7.9 -0.4 4.05e-14 Intelligence (multi-trait analysis); LUSC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg04362960 chr10:104952993 NT5C2 0.58 9.07 0.44 1.03e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4499344 0.604 rs259245 chr19:33145106 A/G cg22980127 chr19:33182716 NUDT19 -0.43 -6.28 -0.33 1.03e-9 Mean platelet volume; LUSC cis rs1153858 0.723 rs4580098 chr15:45596909 T/A cg14582100 chr15:45693742 SPATA5L1 0.54 9.23 0.45 3.18e-18 Homoarginine levels; LUSC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg03929089 chr4:120376271 NA -0.96 -16.62 -0.67 1.28e-45 Height; LUSC cis rs17401966 0.522 rs912962 chr1:10348712 G/T cg17425144 chr1:10567563 PEX14 0.34 6.17 0.32 2.01e-9 Hepatocellular carcinoma; LUSC cis rs8078723 0.866 rs11078934 chr17:38189793 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.42 -6.76 -0.35 6.16e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg04267008 chr7:1944627 MAD1L1 0.42 6.11 0.32 2.7e-9 Bipolar disorder and schizophrenia; LUSC cis rs478304 0.654 rs1074155 chr11:65458197 C/T cg05805236 chr11:65401703 PCNXL3 0.65 10.75 0.51 2.39e-23 Acne (severe); LUSC cis rs941873 0.868 rs7898 chr10:81114959 C/T cg09469691 chr10:81107165 PPIF 0.58 8.77 0.43 9.21e-17 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18339838 chr7:108210215 THAP5;DNAJB9 -0.43 -6.28 -0.32 1.08e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg22166914 chr1:53195759 ZYG11B 0.54 8.83 0.43 6.21e-17 Monocyte count; LUSC cis rs80130819 0.748 rs2932095 chr12:48658212 C/T cg24011408 chr12:48396354 COL2A1 0.46 5.84 0.3 1.22e-8 Prostate cancer; LUSC cis rs1577917 0.839 rs12216103 chr6:86571128 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.29 -0.33 9.98e-10 Response to antipsychotic treatment; LUSC cis rs62400317 0.686 rs860741 chr6:44808435 G/A cg18551225 chr6:44695536 NA 0.45 7.49 0.38 6.39e-13 Total body bone mineral density; LUSC cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg22601191 chr20:60968625 CABLES2 0.55 9.38 0.46 1.03e-18 Colorectal cancer; LUSC cis rs939658 1.000 rs17175798 chr15:79463960 A/G cg17916960 chr15:79447300 NA 0.51 10.28 0.49 9.81e-22 Refractive error; LUSC cis rs11676855 0.924 rs11680626 chr2:235927511 A/T cg14917874 chr2:235941519 SH3BP4 -0.54 -8.55 -0.42 4.56e-16 Dialysis-related mortality; LUSC cis rs8017423 0.967 rs60548738 chr14:90724399 G/A cg04374321 chr14:90722782 PSMC1 0.76 12.13 0.55 2.61e-28 Mortality in heart failure; LUSC cis rs2688608 0.933 rs2633307 chr10:75653881 G/A cg17411546 chr10:75410026 SYNPO2L -0.46 -6.84 -0.35 3.89e-11 Inflammatory bowel disease; LUSC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg26314531 chr2:26401878 FAM59B -0.66 -9.12 -0.45 7.39e-18 Gut microbiome composition (summer); LUSC cis rs7246967 0.673 rs55684269 chr19:22924547 C/T cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs3750965 0.959 rs4930265 chr11:68855954 A/G cg06818126 chr11:68850279 TPCN2 -0.44 -6.58 -0.34 1.86e-10 Hair color; LUSC cis rs56104184 0.830 rs73061622 chr19:49358111 C/T cg15549821 chr19:49342101 PLEKHA4 -0.95 -10.77 -0.51 2.08e-23 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs870825 0.616 rs28450662 chr4:185638900 G/A cg04058563 chr4:185651563 MLF1IP 0.88 13.74 0.6 2.31e-34 Blood protein levels; LUSC cis rs6987853 0.933 rs2974341 chr8:42398302 T/A cg09913449 chr8:42400586 C8orf40 0.49 8.26 0.41 3.35e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs9303401 0.659 rs12150536 chr17:56640834 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.89 0.6 6.36e-35 Cognitive test performance; LUSC cis rs11098499 0.754 rs2036856 chr4:120249288 G/A cg09307838 chr4:120376055 NA 0.69 10.41 0.49 3.68e-22 Corneal astigmatism; LUSC cis rs3947 0.813 rs1293316 chr8:11690915 A/G cg00262122 chr8:11665843 FDFT1 -0.48 -5.87 -0.31 1.04e-8 Blood protein levels; LUSC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg04166393 chr7:2884313 GNA12 0.45 5.98 0.31 5.82e-9 Height; LUSC trans rs1146849 0.671 rs1254236 chr13:72879259 C/T cg00555393 chr10:15077929 NA 0.33 6.07 0.32 3.43e-9 Facial emotion recognition (sad faces); LUSC cis rs9308433 0.569 rs1353718 chr1:214459652 A/T cg06198575 chr1:214491504 SMYD2 0.44 6.75 0.35 6.57e-11 IgG glycosylation; LUSC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg21573476 chr21:45109991 RRP1B -0.36 -5.79 -0.3 1.6e-8 Mean corpuscular volume; LUSC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg02569458 chr12:86230093 RASSF9 0.57 9.75 0.47 6.49e-20 Major depressive disorder; LUSC cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC cis rs6754311 0.593 rs6755383 chr2:136416941 C/T cg07169764 chr2:136633963 MCM6 0.57 7.47 0.38 6.93e-13 Mosquito bite size; LUSC cis rs2290405 1.000 rs2290405 chr4:946974 A/G cg07828340 chr4:882639 GAK 0.42 5.78 0.3 1.76e-8 Systemic sclerosis; LUSC trans rs1997103 1.000 rs6954474 chr7:55404847 A/G cg20935933 chr6:143382018 AIG1 0.51 7.29 0.37 2.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10791097 0.720 rs6590518 chr11:130733530 C/T cg12179176 chr11:130786555 SNX19 0.73 11.41 0.53 1.14e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9807989 0.524 rs7591246 chr2:102999403 C/A cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.27e-12 Asthma; LUSC trans rs7786808 0.741 rs35059736 chr7:158224692 C/T cg02030672 chr11:45687055 CHST1 0.45 6.74 0.35 6.89e-11 Obesity-related traits; LUSC cis rs6967385 0.583 rs7811925 chr7:12351245 C/T cg20607287 chr7:12443886 VWDE 0.4 5.95 0.31 6.72e-9 Response to taxane treatment (placlitaxel); LUSC cis rs7607369 0.714 rs2272190 chr2:219609995 G/C cg02176678 chr2:219576539 TTLL4 -0.58 -10.17 -0.49 2.38e-21 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg26513180 chr16:89883248 FANCA 0.9 17.58 0.69 1.92e-49 Vitiligo; LUSC cis rs3741798 1.000 rs61922027 chr12:12486444 C/T cg08615371 chr12:12503544 MANSC1 1.07 10.76 0.51 2.28e-23 Cerebrospinal fluid biomarker levels; LUSC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg06238570 chr21:40685208 BRWD1 -0.63 -11.0 -0.52 3.14e-24 Cognitive function; LUSC cis rs921968 0.565 rs1078803 chr2:219606538 A/C cg02176678 chr2:219576539 TTLL4 0.54 9.63 0.47 1.56e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs9800506 0.584 rs2011361 chr6:35524394 T/A cg03566752 chr6:35512600 NA 0.34 7.71 0.39 1.42e-13 Neutrophil percentage of granulocytes; LUSC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg06636001 chr8:8085503 FLJ10661 -0.86 -14.36 -0.62 9.24e-37 Schizophrenia; LUSC cis rs67072384 0.901 rs11235586 chr11:72476025 C/G cg04827223 chr11:72435913 ARAP1 -0.77 -5.84 -0.3 1.24e-8 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs11098499 0.955 rs6815725 chr4:120158410 C/A cg24375607 chr4:120327624 NA 0.75 11.48 0.53 6.19e-26 Corneal astigmatism; LUSC cis rs243505 1.000 rs243512 chr7:148430062 C/T cg09806900 chr7:148480153 CUL1 -0.49 -6.94 -0.35 2.06e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg26384229 chr12:38710491 ALG10B 0.91 15.31 0.64 1.88e-40 Bladder cancer; LUSC trans rs2562456 0.833 rs55920089 chr19:21520693 A/T cg00806126 chr19:22604979 ZNF98 -0.43 -6.15 -0.32 2.25e-9 Pain; LUSC cis rs7927592 0.871 rs12360903 chr11:68236314 C/A cg16797656 chr11:68205561 LRP5 0.37 6.14 0.32 2.34e-9 Total body bone mineral density; LUSC cis rs1950626 0.833 rs12892225 chr14:101415413 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.42 7.44 0.38 8.76e-13 Pelvic organ prolapse (moderate/severe); LUSC trans rs62103177 0.525 rs4799116 chr18:77736735 A/G cg14227996 chr4:17616232 MED28 -0.55 -6.25 -0.32 1.23e-9 Opioid sensitivity; LUSC cis rs62209 0.752 rs11256941 chr10:11017020 G/T cg26901096 chr10:10994189 LOC254312 0.39 6.16 0.32 2.1e-9 Alzheimer's disease (late onset); LUSC cis rs977987 0.806 rs6564252 chr16:75388940 C/T cg03315344 chr16:75512273 CHST6 0.51 9.65 0.47 1.31e-19 Dupuytren's disease; LUSC cis rs6565180 1.000 rs11862806 chr16:30364071 A/G cg17640201 chr16:30407289 ZNF48 -0.87 -15.42 -0.64 6.95e-41 Tonsillectomy; LUSC cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg23262351 chr6:79576851 IRAK1BP1 -0.37 -5.66 -0.3 3.23e-8 Intelligence (multi-trait analysis); LUSC cis rs9322817 0.691 rs2486141 chr6:105299930 G/A cg02098413 chr6:105308735 HACE1 0.27 5.68 0.3 2.95e-8 Thyroid stimulating hormone; LUSC cis rs7177699 0.557 rs3971829 chr15:79109052 A/G cg15571903 chr15:79123663 NA 0.34 6.19 0.32 1.81e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6563842 0.563 rs9603786 chr13:41316364 G/A cg21288729 chr13:41239152 FOXO1 0.52 7.71 0.39 1.42e-13 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC cis rs9952991 0.941 rs888270 chr18:12774894 G/A cg23544223 chr18:12777786 NA -0.59 -6.11 -0.32 2.77e-9 Inflammatory skin disease; LUSC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg10018233 chr7:150070692 REPIN1 -0.36 -6.38 -0.33 5.95e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg14440974 chr22:39074834 NA -0.4 -6.62 -0.34 1.46e-10 Menopause (age at onset); LUSC cis rs13202913 0.779 rs9383896 chr6:151768495 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.63 5.67 0.3 3.12e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg11062466 chr8:58055876 NA 0.58 8.25 0.41 3.76e-15 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg05347473 chr6:146136440 FBXO30 -0.54 -9.27 -0.45 2.3e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.44 6.95 0.36 1.96e-11 Bipolar disorder; LUSC cis rs9640161 0.711 rs3735170 chr7:150034184 T/C cg17279839 chr7:150038598 RARRES2 0.54 8.15 0.41 7.57e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs16854884 0.657 rs6440210 chr3:143705763 A/G cg06585982 chr3:143692056 C3orf58 0.48 7.38 0.37 1.23e-12 Economic and political preferences (feminism/equality); LUSC cis rs7616215 0.519 rs2133664 chr3:46101774 T/A cg19145607 chr3:45983792 CXCR6;FYCO1 0.32 5.72 0.3 2.39e-8 Behcet's disease; LUSC cis rs12681287 0.547 rs13261956 chr8:87478765 G/A cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg11244672 chr19:19639970 YJEFN3 -0.55 -6.7 -0.34 9.01e-11 Bipolar disorder; LUSC cis rs12530845 0.945 rs59664351 chr7:135314717 C/A cg23117316 chr7:135346802 PL-5283 -0.57 -9.93 -0.48 1.61e-20 Red blood cell traits; LUSC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg24733560 chr20:60626293 TAF4 0.4 6.45 0.33 3.98e-10 Body mass index; LUSC cis rs11997175 0.546 rs11778519 chr8:33615873 G/A ch.8.33884649F chr8:33765107 NA 0.51 8.12 0.41 9.29e-15 Body mass index; LUSC trans rs561341 0.824 rs1978115 chr17:30220776 A/C cg27661571 chr11:113659931 NA -0.57 -6.31 -0.33 8.73e-10 Hip circumference adjusted for BMI; LUSC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg08392591 chr16:89556376 ANKRD11 0.47 7.24 0.37 3.03e-12 Multiple myeloma (IgH translocation); LUSC cis rs3768617 0.510 rs12095664 chr1:183101686 G/A ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg21699342 chr2:239360505 ASB1 -0.42 -6.05 -0.31 3.91e-9 Multiple system atrophy; LUSC cis rs7727544 0.716 rs6863213 chr5:131575932 C/T cg09877947 chr5:131593287 PDLIM4 0.38 6.3 0.33 9.24e-10 Blood metabolite levels; LUSC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg21361702 chr7:150065534 REPIN1 0.45 6.28 0.33 1.03e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.52 -0.34 2.6200000000000003e-10 Lung cancer; LUSC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg13902645 chr11:5959945 NA 0.56 8.91 0.44 3.38e-17 DNA methylation (variation); LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg11608241 chr8:8085544 FLJ10661 -0.5 -7.18 -0.37 4.55e-12 Neuroticism; LUSC trans rs1994135 0.608 rs1482994 chr12:33713631 T/C cg13010199 chr12:38710504 ALG10B 0.56 7.7 0.39 1.59e-13 Resting heart rate; LUSC cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg23711669 chr6:146136114 FBXO30 0.82 14.38 0.62 8.11e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs4499344 0.730 rs2868150 chr19:33098875 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC trans rs9467603 0.925 rs3949215 chr6:25777497 A/T cg06606381 chr12:133084897 FBRSL1 0.59 5.95 0.31 6.9e-9 Intelligence (multi-trait analysis); LUSC cis rs4474465 0.850 rs10793322 chr11:78242615 T/C cg27205649 chr11:78285834 NARS2 0.51 6.07 0.32 3.48e-9 Alzheimer's disease (survival time); LUSC cis rs2070488 0.775 rs6794397 chr3:38559307 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.69 12.1 0.55 3.51e-28 Electrocardiographic conduction measures; LUSC cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg21466736 chr12:48725269 NA -0.33 -5.73 -0.3 2.21e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg18132916 chr6:79620363 NA -0.39 -5.92 -0.31 8.18e-9 Intelligence (multi-trait analysis); LUSC cis rs7084921 0.533 rs12765091 chr10:101855231 G/C cg02250046 chr10:101825185 CPN1 -0.34 -6.12 -0.32 2.63e-9 Bone mineral density; LUSC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.95 0.4 2.88e-14 Electroencephalogram traits; LUSC cis rs4964805 0.657 rs1866294 chr12:104186795 A/G cg02344784 chr12:104178138 NT5DC3 0.46 8.81 0.43 6.71e-17 Attention deficit hyperactivity disorder; LUSC cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg23649088 chr2:200775458 C2orf69 0.49 6.71 0.34 8.6e-11 Schizophrenia; LUSC cis rs73198271 0.740 rs10098636 chr8:8647324 C/T cg01851573 chr8:8652454 MFHAS1 0.53 8.45 0.42 8.97e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2414856 0.510 rs72757000 chr15:64613476 A/G cg08069370 chr15:64387884 SNX1 -0.77 -6.56 -0.34 2.06e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.53e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs9814567 0.896 rs4435682 chr3:134344182 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 0.31 5.86 0.31 1.09e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg19046167 chr17:80928561 B3GNTL1 0.5 7.09 0.36 7.81e-12 Glycated hemoglobin levels; LUSC cis rs7808935 0.768 rs757138 chr7:27989403 T/G cg22168087 chr7:27702803 HIBADH 0.46 5.97 0.31 5.99e-9 Prostate cancer; LUSC cis rs7582180 0.629 rs11686842 chr2:100956139 C/T cg12002119 chr2:101014098 CHST10 0.35 5.65 0.3 3.35e-8 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.01 0.31 4.84e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8058578 1.000 rs67128646 chr16:30672097 A/C cg02466173 chr16:30829666 NA -0.6 -10.79 -0.51 1.73e-23 Multiple myeloma; LUSC cis rs9837602 1.000 rs13064704 chr3:99767541 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.89 -0.31 9.61e-9 Breast cancer; LUSC trans rs11992162 0.550 rs61426048 chr8:11784956 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.21 -0.32 1.62e-9 Monocyte count; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.49 -0.33 3.04e-10 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg11060661 chr22:24314208 DDT;DDTL 0.41 6.81 0.35 4.49e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.64 0.39 2.29e-13 Prudent dietary pattern; LUSC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg06108461 chr20:60628389 TAF4 -0.74 -11.88 -0.54 2.19e-27 Body mass index; LUSC cis rs12893668 0.667 rs8017628 chr14:104047428 C/T cg01849466 chr14:104193079 ZFYVE21 -0.45 -6.41 -0.33 4.95e-10 Reticulocyte count; LUSC cis rs7809950 0.798 rs10281535 chr7:107229618 T/G cg23024343 chr7:107201750 COG5 0.55 8.62 0.43 2.68e-16 Coronary artery disease; LUSC cis rs11208691 0.513 rs72480644 chr1:66159417 C/G cg14976592 chr1:65886160 LEPROT;LEPR 0.51 5.88 0.31 9.88e-9 Lymphocyte percentage of white cells; LUSC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.67e-10 Lung cancer; LUSC cis rs6964587 0.967 rs4729015 chr7:91561592 T/G cg22709100 chr7:91322751 NA -0.4 -5.83 -0.3 1.3e-8 Breast cancer; LUSC cis rs3820068 0.608 rs12734937 chr1:16047726 T/C cg13390004 chr1:15929781 NA 0.41 6.59 0.34 1.73e-10 Systolic blood pressure; LUSC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg12463550 chr7:65579703 CRCP 0.5 7.03 0.36 1.15e-11 Aortic root size; LUSC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.86e-12 Blood metabolite levels; LUSC cis rs4595586 0.545 rs1303887 chr12:39366523 C/T cg26384229 chr12:38710491 ALG10B 0.49 7.06 0.36 9.89e-12 Morning vs. evening chronotype; LUSC cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg10978503 chr1:24200527 CNR2 0.47 10.89 0.51 7.57e-24 Immature fraction of reticulocytes; LUSC cis rs9287719 0.967 rs11674433 chr2:10730839 T/C cg00105475 chr2:10696890 NA 0.37 6.09 0.32 3.03e-9 Prostate cancer; LUSC cis rs6456156 0.565 rs12529238 chr6:167465576 G/A cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg16606324 chr3:10149918 C3orf24 0.59 7.88 0.4 4.61e-14 Alzheimer's disease; LUSC cis rs9768139 0.683 rs4909178 chr7:158117752 T/A cg06219351 chr7:158114137 PTPRN2 -0.53 -9.67 -0.47 1.16e-19 Calcium levels; LUSC cis rs6692729 0.931 rs2855562 chr1:227081850 G/A cg10327440 chr1:227177885 CDC42BPA -0.45 -6.17 -0.32 1.97e-9 Electrodermal activity; LUSC cis rs6547741 0.844 rs7586655 chr2:27915659 A/G cg27432699 chr2:27873401 GPN1 -0.88 -17.68 -0.7 8.07e-50 Oral cavity cancer; LUSC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.14 0.36 5.83e-12 Major depressive disorder; LUSC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 2e-14 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.566 rs10946207 chr6:167456036 C/T cg07741184 chr6:167504864 NA 0.48 8.19 0.41 5.46e-15 Crohn's disease; LUSC cis rs713477 0.524 rs4901560 chr14:55888533 C/T cg13175173 chr14:55914753 NA 0.32 6.01 0.31 4.93e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs5753618 0.561 rs2283881 chr22:31638932 G/A cg22777020 chr22:31556080 RNF185 -0.45 -5.79 -0.3 1.6e-8 Colorectal cancer; LUSC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg18876405 chr7:65276391 NA -0.7 -12.66 -0.57 2.88e-30 Aortic root size; LUSC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg03732007 chr1:2071316 PRKCZ -0.5 -8.73 -0.43 1.23e-16 Height; LUSC cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg00152838 chr16:24741724 TNRC6A -0.46 -5.73 -0.3 2.2e-8 Intelligence (multi-trait analysis); LUSC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg00825309 chr19:58991885 ZNF446 -0.49 -7.07 -0.36 9.18e-12 Uric acid clearance; LUSC trans rs979233 0.502 rs276240 chr5:42059928 A/G cg07010552 chr17:7358735 CHRNB1 0.44 6.3 0.33 9.56e-10 Systemic lupus erythematosus; LUSC cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs1775715 0.675 rs2808085 chr10:32148599 C/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.57 0.34 1.95e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs41271473 0.898 rs55730631 chr1:228865663 C/A cg10167378 chr1:228756711 NA 0.58 6.96 0.36 1.77e-11 Chronic lymphocytic leukemia; LUSC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg11871910 chr12:69753446 YEATS4 0.67 10.4 0.49 4.03e-22 Blood protein levels; LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg24503407 chr1:205819492 PM20D1 -0.54 -8.52 -0.42 5.6e-16 Menarche (age at onset); LUSC cis rs34311866 0.808 rs62294491 chr4:969111 C/T cg07828340 chr4:882639 GAK 0.96 9.8 0.47 4.19e-20 Parkinson's disease; LUSC cis rs73206853 0.563 rs9706102 chr12:111185391 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 6.91 0.35 2.49e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7247513 0.797 rs3815914 chr19:12760664 T/C cg01871581 chr19:12707946 ZNF490 -0.5 -7.35 -0.37 1.56e-12 Bipolar disorder; LUSC cis rs16958440 0.867 rs2117373 chr18:44671834 C/T cg17192377 chr18:44677553 HDHD2 0.67 7.08 0.36 8.51e-12 Sitting height ratio; LUSC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg14552801 chr7:65878734 NA 0.38 5.94 0.31 7.28e-9 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15996282 chr5:36152109 LMBRD2;SKP2 -0.41 -5.96 -0.31 6.25e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs668210 0.793 rs1151514 chr11:65758854 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.59 7.82 0.39 6.97e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs9462027 0.628 rs28675115 chr6:34732514 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.91 -0.31 8.62e-9 Systemic lupus erythematosus; LUSC cis rs6700896 0.500 rs2186245 chr1:66118064 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.36 0.33 6.62e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg08677398 chr8:58056175 NA 0.52 7.2 0.37 4.08e-12 Developmental language disorder (linguistic errors); LUSC cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg27279351 chr12:120934652 DYNLL1 0.59 7.85 0.39 5.74e-14 High light scatter reticulocyte count; LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg00684032 chr4:1343700 KIAA1530 0.33 5.83 0.3 1.28e-8 Obesity-related traits; LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -6.24 -0.32 1.33e-9 Developmental language disorder (linguistic errors); LUSC cis rs6688613 0.545 rs10800270 chr1:166827602 A/T cg07049167 chr1:166818506 POGK 0.55 7.83 0.39 6.55e-14 Refractive astigmatism; LUSC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg19729930 chr2:74357872 NA 0.88 16.45 0.67 5.83e-45 Gestational age at birth (maternal effect); LUSC cis rs2299587 0.689 rs1847154 chr8:17780338 A/G cg01800426 chr8:17659068 MTUS1 -0.43 -5.78 -0.3 1.7e-8 Economic and political preferences; LUSC cis rs694739 0.687 rs11231771 chr11:64140642 T/G cg23796481 chr11:64053134 BAD;GPR137 0.53 8.18 0.41 6.18e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs2486288 0.656 rs11632778 chr15:45551056 C/T cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.8 -0.51 1.62e-23 Glomerular filtration rate; LUSC cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg08999081 chr20:33150536 PIGU 0.51 10.19 0.49 2e-21 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg12463550 chr7:65579703 CRCP 0.48 7.2 0.37 4.03e-12 Aortic root size; LUSC cis rs713587 0.935 rs4430895 chr2:25161386 C/T cg04586622 chr2:25135609 ADCY3 0.32 6.45 0.33 4e-10 Body mass index in non-asthmatics; LUSC cis rs231513 1.000 rs231499 chr17:41973507 C/T cg26893861 chr17:41843967 DUSP3 0.52 6.19 0.32 1.72e-9 Cognitive function; LUSC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg21984481 chr17:79567631 NPLOC4 -0.57 -10.89 -0.51 7.97e-24 Eye color traits; LUSC cis rs9462027 0.628 rs9469886 chr6:34758824 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC cis rs1784581 0.588 rs9295179 chr6:162420546 G/A cg17173639 chr6:162384350 PARK2 0.57 9.91 0.48 1.8e-20 Itch intensity from mosquito bite; LUSC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg21433313 chr16:3507492 NAT15 0.65 10.97 0.51 4.16e-24 Tuberculosis; LUSC cis rs597539 0.521 rs7943745 chr11:68605828 A/G cg21862992 chr11:68658383 NA -0.34 -5.72 -0.3 2.32e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12210905 0.688 rs114843651 chr6:27449611 A/G cg08851530 chr6:28072375 NA 0.97 6.01 0.31 4.99e-9 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.24 0.52 4.53e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg06637938 chr14:75390232 RPS6KL1 -0.47 -7.04 -0.36 1.08e-11 Height; LUSC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg24154853 chr7:158122151 PTPRN2 0.45 8.8 0.43 7.55e-17 Calcium levels; LUSC cis rs12999616 0.817 rs35321033 chr2:98327812 T/C cg26665480 chr2:98280029 ACTR1B 0.53 6.05 0.31 3.91e-9 Colorectal cancer; LUSC cis rs12900413 0.687 rs10152954 chr15:90307442 T/C cg24249390 chr15:90295951 MESP1 -0.38 -6.0 -0.31 5e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg26304593 chr6:42947056 PEX6 -0.54 -8.49 -0.42 6.8e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9660992 0.710 rs1172136 chr1:205247097 T/G cg21545522 chr1:205238299 TMCC2 0.5 9.36 0.46 1.21e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg13390004 chr1:15929781 NA 0.42 7.0 0.36 1.43e-11 Systolic blood pressure; LUSC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg08564027 chr20:61660810 NA 0.9 17.01 0.68 3.71e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg04450456 chr4:17643702 FAM184B 0.35 5.8 0.3 1.56e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13089785 1.000 rs13071800 chr3:123626813 C/A cg19611163 chr3:123411211 MYLK 0.34 5.77 0.3 1.84e-8 Intelligence (multi-trait analysis); LUSC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 7.19 0.37 4.39e-12 Platelet count; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg07167872 chr1:205819463 PM20D1 0.9 17.74 0.7 4.53e-50 Menarche (age at onset); LUSC cis rs1577917 0.958 rs2197648 chr6:86543887 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.85 -0.35 3.55e-11 Response to antipsychotic treatment; LUSC trans rs1486139 1.000 rs4464869 chr7:46284640 A/G cg17534202 chr9:96721102 NA -0.37 -6.5 -0.34 2.86e-10 Select biomarker traits; LUSC cis rs6542838 0.704 rs13011428 chr2:99528305 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -6.02 -0.31 4.63e-9 Fear of minor pain; LUSC cis rs7927592 0.913 rs10896346 chr11:68352671 C/T cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.58e-9 Total body bone mineral density; LUSC cis rs1577917 1.000 rs7756203 chr6:86627707 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC cis rs9611565 0.592 rs57102627 chr22:41987627 T/C cg03806693 chr22:41940476 POLR3H -0.91 -12.72 -0.57 1.7e-30 Vitiligo; LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -7.72 -0.39 1.39e-13 Bipolar disorder and schizophrenia; LUSC cis rs1557765 0.527 rs2018218 chr11:17390855 A/G cg15432903 chr11:17409602 KCNJ11 0.43 7.6 0.38 2.96e-13 Body mass index;Social communication problems; LUSC cis rs9790314 0.905 rs7633186 chr3:161003124 A/G cg04691961 chr3:161091175 C3orf57 -0.35 -5.97 -0.31 6.09e-9 Morning vs. evening chronotype; LUSC cis rs72717009 0.825 rs12746613 chr1:161467042 A/G cg23840854 chr1:161414152 NA 0.9 10.79 0.51 1.73e-23 Rheumatoid arthritis; LUSC cis rs4595586 0.545 rs61939641 chr12:39378001 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs12900413 0.687 rs62023459 chr15:90308231 A/T cg24249390 chr15:90295951 MESP1 -0.37 -5.87 -0.31 1.03e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs7582720 1.000 rs75166090 chr2:203692760 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.64 0.43 2.43e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg24578937 chr1:2090814 PRKCZ -0.43 -9.55 -0.46 2.78e-19 Height; LUSC cis rs7824557 0.815 rs958648 chr8:11103895 A/G cg21775007 chr8:11205619 TDH -0.49 -7.26 -0.37 2.66e-12 Retinal vascular caliber; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg05131766 chr16:47495110 PHKB;ITFG1 0.4 6.24 0.32 1.33e-9 Educational attainment (years of education); LUSC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg08742575 chr21:47604166 C21orf56 0.45 6.59 0.34 1.7e-10 Testicular germ cell tumor; LUSC cis rs7107174 1.000 rs58565853 chr11:78036707 C/T cg02023728 chr11:77925099 USP35 0.46 6.97 0.36 1.71e-11 Testicular germ cell tumor; LUSC cis rs10791323 0.559 rs10750549 chr11:133730820 A/G cg00579200 chr11:133705235 NA -0.39 -5.86 -0.31 1.14e-8 Childhood ear infection; LUSC trans rs7939886 0.920 rs11227212 chr11:55873334 A/G cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC trans rs12579753 0.956 rs7309624 chr12:82204266 C/A cg07923666 chr12:49932857 KCNH3 -0.52 -6.51 -0.34 2.74e-10 Resting heart rate; LUSC cis rs12136530 0.774 rs10442642 chr1:19773818 A/G cg01832549 chr1:19774989 CAPZB -0.33 -5.92 -0.31 7.96e-9 Lead levels in blood; LUSC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg12463550 chr7:65579703 CRCP 0.57 8.46 0.42 8.25e-16 Aortic root size; LUSC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs7833790 0.777 rs7815272 chr8:82691809 T/G cg17211192 chr8:82754475 SNX16 -0.76 -10.05 -0.48 6.13e-21 Diastolic blood pressure; LUSC cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.08 0.52 1.59e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4474465 1.000 rs6592779 chr11:78197283 G/C cg27205649 chr11:78285834 NARS2 -0.55 -6.3 -0.33 9.65e-10 Alzheimer's disease (survival time); LUSC cis rs4919687 0.550 rs11191371 chr10:104459897 G/C cg05855489 chr10:104503620 C10orf26 0.71 11.55 0.53 3.39e-26 Colorectal cancer; LUSC trans rs9747201 1.000 rs3922470 chr17:80110159 C/T cg07393940 chr7:158741817 NA -0.51 -8.2 -0.41 5.11e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg09085632 chr11:111637200 PPP2R1B -1.03 -15.47 -0.65 4.49e-41 Primary sclerosing cholangitis; LUSC cis rs897984 0.568 rs4889651 chr16:30895545 C/T cg02466173 chr16:30829666 NA -0.51 -8.4 -0.42 1.32e-15 Dementia with Lewy bodies; LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.79 0.6 1.44e-34 Platelet count; LUSC cis rs7617773 0.780 rs11718350 chr3:48360992 T/G cg20734569 chr3:48348370 SPINK8 -0.47 -7.9 -0.4 4.12e-14 Coronary artery disease; LUSC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg02248941 chr16:2239361 CASKIN1 0.42 7.97 0.4 2.52e-14 Height; LUSC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg03526776 chr6:41159608 TREML2 0.33 6.12 0.32 2.67e-9 Alzheimer's disease (late onset); LUSC cis rs7940866 0.874 rs7112616 chr11:130805334 T/C cg12179176 chr11:130786555 SNX19 0.62 9.39 0.46 9.33e-19 Schizophrenia; LUSC cis rs1153858 1.000 rs1145085 chr15:45657804 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.31 0.41 2.49e-15 Homoarginine levels; LUSC trans rs7824557 0.701 rs2060465 chr8:11162609 T/C cg06636001 chr8:8085503 FLJ10661 0.51 7.66 0.39 2.06e-13 Retinal vascular caliber; LUSC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg12412775 chr1:25698385 RHCE -0.31 -6.4 -0.33 5.3e-10 Erythrocyte sedimentation rate; LUSC cis rs10186029 0.676 rs10804213 chr2:213964399 G/A cg08319019 chr2:214017104 IKZF2 0.6 8.86 0.44 4.71e-17 Systemic sclerosis; LUSC cis rs7712401 0.755 rs1545697 chr5:122102277 T/C cg19077854 chr5:122220652 SNX24 0.35 7.8 0.39 7.8500000000000006e-14 Mean platelet volume; LUSC cis rs2652822 0.967 rs4775633 chr15:63437746 G/A cg02713581 chr15:63449717 RPS27L 0.42 6.63 0.34 1.36e-10 Metabolic traits; LUSC cis rs7954584 0.504 rs10840633 chr12:122377511 A/T cg01765077 chr12:122356316 WDR66 0.55 7.64 0.39 2.34e-13 Mean corpuscular volume; LUSC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg13770153 chr20:60521292 NA -0.62 -8.39 -0.42 1.36e-15 Body mass index; LUSC cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg21535247 chr6:8435926 SLC35B3 0.58 9.01 0.44 1.65e-17 Motion sickness; LUSC cis rs34638657 0.827 rs3829548 chr16:82206238 C/G cg07918374 chr16:82182319 MPHOSPH6 -0.6 -6.07 -0.32 3.41e-9 Lung adenocarcinoma; LUSC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg00310523 chr12:86230176 RASSF9 0.52 9.83 0.47 3.52e-20 Major depressive disorder; LUSC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg06713675 chr4:122721982 EXOSC9 -0.72 -12.31 -0.56 5.85e-29 Type 2 diabetes; LUSC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.49 0.5 1.95e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs61931739 0.929 rs10844730 chr12:34026721 C/G cg26384229 chr12:38710491 ALG10B -0.58 -9.22 -0.45 3.42e-18 Morning vs. evening chronotype; LUSC trans rs1941687 0.797 rs6507071 chr18:31393333 C/T cg27147174 chr7:100797783 AP1S1 -0.44 -6.41 -0.33 4.82e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg17691542 chr6:26056736 HIST1H1C -0.58 -7.2 -0.37 4.07e-12 Iron status biomarkers; LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.12e-18 Menopause (age at onset); LUSC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg09267113 chr7:98030324 BAIAP2L1 0.4 5.96 0.31 6.34e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3785574 0.536 rs2854190 chr17:61960219 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.59 8.81 0.43 6.73e-17 Height; LUSC cis rs2255336 0.748 rs60110638 chr12:10597311 A/T cg16084090 chr12:10586130 KLRC2 -0.45 -5.8 -0.3 1.53e-8 Blood protein levels; LUSC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -7.32 -0.37 1.92e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9355610 0.609 rs7772112 chr6:167408896 G/A cg23791538 chr6:167370224 RNASET2 0.44 6.15 0.32 2.2e-9 Graves' disease; LUSC cis rs500891 0.645 rs1180188 chr6:83967295 A/T cg08257003 chr6:84140564 ME1 0.3 6.7 0.34 8.8e-11 Platelet-derived growth factor BB levels; LUSC cis rs6754311 0.593 rs10928542 chr2:136410299 G/A cg07169764 chr2:136633963 MCM6 0.55 7.25 0.37 2.94e-12 Mosquito bite size; LUSC cis rs1419980 0.722 rs752452 chr12:7781021 G/A cg25828445 chr12:7781288 NA 0.62 6.59 0.34 1.67e-10 HDL cholesterol levels; LUSC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg25174290 chr11:3078921 CARS 0.54 7.97 0.4 2.59e-14 Longevity; LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg06145435 chr7:1022769 CYP2W1 0.3 6.37 0.33 6.23e-10 Longevity;Endometriosis; LUSC cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3741151 0.686 rs7944346 chr11:73244230 C/T cg17517138 chr11:73019481 ARHGEF17 0.79 7.52 0.38 5.1e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10791323 0.633 rs2171006 chr11:133728323 T/C cg00579200 chr11:133705235 NA -0.39 -5.92 -0.31 8.19e-9 Childhood ear infection; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg02475777 chr4:1388615 CRIPAK 0.44 6.5 0.34 2.92e-10 Obesity-related traits; LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg08219700 chr8:58056026 NA 0.69 7.91 0.4 3.7e-14 Developmental language disorder (linguistic errors); LUSC trans rs7939886 0.920 rs4612826 chr11:55948005 C/A cg03929089 chr4:120376271 NA 0.82 6.22 0.32 1.53e-9 Myopia (pathological); LUSC cis rs4664304 1.000 rs57771571 chr2:160767804 G/C cg03641300 chr2:160917029 PLA2R1 -0.41 -6.78 -0.35 5.41e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs6424115 0.545 rs11576333 chr1:24065770 C/T cg15997130 chr1:24165203 NA -0.45 -6.28 -0.33 1.04e-9 Immature fraction of reticulocytes; LUSC cis rs1348850 0.793 rs6734528 chr2:178493731 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.83 0.3 1.31e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.62 0.43 2.76e-16 Height; LUSC cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg23711669 chr6:146136114 FBXO30 0.88 16.36 0.67 1.34e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.2 -0.32 1.65e-9 Bipolar disorder; LUSC cis rs9486719 1.000 rs2472897 chr6:96870569 G/T cg06623918 chr6:96969491 KIAA0776 0.8 9.92 0.48 1.75e-20 Migraine;Coronary artery disease; LUSC trans rs1532331 0.548 rs6894506 chr5:43169096 C/T cg17870909 chr21:47566968 FTCD 0.25 5.96 0.31 6.28e-9 Menarche (age at onset); LUSC cis rs56283067 0.887 rs62437973 chr6:44761978 G/A cg18551225 chr6:44695536 NA -0.48 -7.61 -0.38 2.8e-13 Total body bone mineral density; LUSC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg05738196 chr6:26577821 NA -0.47 -6.12 -0.32 2.69e-9 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.593 rs11182590 chr12:38574274 A/T cg26384229 chr12:38710491 ALG10B 0.68 10.62 0.5 6.72e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs11532322 1 rs11532322 chr12:123731423 A/G cg00376283 chr12:123451042 ABCB9 0.69 9.81 0.47 3.82e-20 Schizophrenia; LUSC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg11062466 chr8:58055876 NA 0.66 8.57 0.42 3.86e-16 Developmental language disorder (linguistic errors); LUSC cis rs4654899 0.865 rs61779075 chr1:21417027 T/C cg02927042 chr1:21476669 EIF4G3 -0.4 -6.3 -0.33 9.29e-10 Superior frontal gyrus grey matter volume; LUSC cis rs8060686 0.641 rs12446007 chr16:68189054 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg23788917 chr6:8435910 SLC35B3 0.49 7.47 0.38 7.01e-13 Motion sickness; LUSC cis rs73206853 0.620 rs73194035 chr12:111165793 A/G cg12870014 chr12:110450643 ANKRD13A 0.82 6.97 0.36 1.67e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs11229555 0.645 rs11229427 chr11:58180275 A/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs11250098 0.503 rs13270870 chr8:10770782 A/G cg27411982 chr8:10470053 RP1L1 -0.45 -6.65 -0.34 1.17e-10 Morning vs. evening chronotype; LUSC cis rs7824557 0.592 rs920044 chr8:11224313 C/T cg21293242 chr8:11204541 TDH 0.34 6.3 0.33 9.19e-10 Retinal vascular caliber; LUSC cis rs2708977 0.699 rs631746 chr2:97065499 A/G cg01950434 chr2:97203154 ARID5A -0.49 -6.64 -0.34 1.28e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg17971929 chr21:40555470 PSMG1 -0.47 -7.13 -0.36 6.12e-12 Menarche (age at onset); LUSC cis rs2120019 0.567 rs8029351 chr15:75177237 A/C cg17294928 chr15:75287854 SCAMP5 -0.77 -8.86 -0.44 4.7e-17 Blood trace element (Zn levels); LUSC cis rs2237234 0.580 rs7763910 chr6:26472655 C/T cg09904177 chr6:26538194 HMGN4 -0.48 -7.46 -0.38 7.39e-13 Autism spectrum disorder or schizophrenia; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg13918937 chr19:4670319 C19orf10 0.42 6.67 0.34 1.03e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.87 -0.35 3.17e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg02380750 chr20:61661411 NA 0.34 5.93 0.31 7.57e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg24250549 chr1:154909240 PMVK 0.64 10.36 0.49 5.26e-22 Prostate cancer; LUSC cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg16586182 chr3:47516702 SCAP -0.52 -7.99 -0.4 2.18e-14 Colorectal cancer; LUSC cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg26647111 chr11:31128758 NA -0.42 -6.05 -0.31 3.81e-9 Red blood cell count; LUSC cis rs1007190 0.764 rs758020 chr17:42872579 C/A cg15406952 chr17:42872593 NA -0.59 -6.13 -0.32 2.45e-9 DNA methylation (variation); LUSC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg06850241 chr22:41845214 NA -0.31 -5.7 -0.3 2.7e-8 Vitiligo; LUSC cis rs7659604 0.540 rs28672860 chr4:122705051 G/A cg20573242 chr4:122745356 CCNA2 -0.45 -6.74 -0.35 7.12e-11 Type 2 diabetes; LUSC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.46 -6.82 -0.35 4.33e-11 Bipolar disorder; LUSC cis rs7223966 1.000 rs113134232 chr17:61715461 G/A cg05941027 chr17:61774174 LIMD2 0.23 5.88 0.31 9.69e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg12751644 chr20:60527061 NA -0.34 -6.18 -0.32 1.88e-9 Body mass index; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.9 0.58 3.43e-31 Alzheimer's disease; LUSC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6500602 0.929 rs9926114 chr16:4478322 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.48 6.15 0.32 2.21e-9 Schizophrenia; LUSC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 9.87 0.48 2.52e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -9.64 -0.47 1.42e-19 Bone mineral density; LUSC cis rs2710642 0.678 rs11125946 chr2:63298150 C/T cg17519650 chr2:63277830 OTX1 -0.52 -7.19 -0.37 4.2e-12 LDL cholesterol levels;LDL cholesterol; LUSC cis rs9549260 0.753 rs2297628 chr13:41233905 T/C cg21288729 chr13:41239152 FOXO1 0.56 6.29 0.33 9.83e-10 Red blood cell count; LUSC cis rs4595586 0.545 rs12812959 chr12:39371197 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.87 0.31 1.06e-8 Morning vs. evening chronotype; LUSC trans rs34421088 0.560 rs2245357 chr8:11399484 A/T cg15556689 chr8:8085844 FLJ10661 -0.61 -9.62 -0.47 1.63e-19 Neuroticism; LUSC trans rs9951602 0.573 rs8098953 chr18:76648734 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.15 0.58 4.22e-32 Obesity-related traits; LUSC cis rs2398893 1.000 rs10993017 chr9:96760384 C/T cg14459158 chr9:96720562 NA -0.31 -5.96 -0.31 6.36e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2011503 0.941 rs55822665 chr19:19383298 C/T cg15839431 chr19:19639596 YJEFN3 -0.59 -6.51 -0.34 2.79e-10 Bipolar disorder; LUSC trans rs6582630 0.555 rs11182217 chr12:38480030 G/A cg06521331 chr12:34319734 NA -0.38 -5.95 -0.31 6.7e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs7246657 0.943 rs7252325 chr19:37930645 A/G cg23950597 chr19:37808831 NA -0.63 -7.53 -0.38 4.71e-13 Coronary artery calcification; LUSC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg06740227 chr12:86229804 RASSF9 -0.44 -7.05 -0.36 1.02e-11 Major depressive disorder; LUSC cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg27446573 chr6:127587934 RNF146 0.92 15.1 0.64 1.27e-39 Breast cancer; LUSC cis rs2281845 0.965 rs3738262 chr1:201083343 A/G cg17810781 chr1:201082982 CACNA1S 0.31 5.92 0.31 7.79e-9 Permanent tooth development; LUSC cis rs7937682 0.564 rs10891277 chr11:111373103 A/G cg09085632 chr11:111637200 PPP2R1B 0.46 6.07 0.32 3.47e-9 Primary sclerosing cholangitis; LUSC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg00074818 chr8:8560427 CLDN23 0.59 9.92 0.48 1.71e-20 Obesity-related traits; LUSC trans rs1814175 0.817 rs10128730 chr11:50023369 G/T cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs2540226 0.655 rs2716681 chr2:39932862 G/A cg23576258 chr2:39999331 THUMPD2 0.35 5.84 0.3 1.21e-8 Personality dimensions; LUSC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg06618935 chr21:46677482 NA -0.39 -7.6 -0.38 3.05e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6733011 0.500 rs6755640 chr2:99445917 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.39 -0.33 5.55e-10 Bipolar disorder; LUSC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg03517284 chr6:25882590 NA 0.4 6.74 0.35 6.84e-11 Intelligence (multi-trait analysis); LUSC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg13393036 chr8:95962371 TP53INP1 -0.47 -9.69 -0.47 9.74e-20 Type 2 diabetes; LUSC cis rs9811920 0.715 rs1017967 chr3:99905803 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.32 6.15 0.32 2.16e-9 Axial length; LUSC cis rs7647973 1.000 rs7619789 chr3:49476263 T/C cg07636037 chr3:49044803 WDR6 0.7 9.42 0.46 7.44e-19 Menarche (age at onset); LUSC trans rs1015291 0.708 rs1586838 chr12:19998182 A/G cg01501474 chr7:55323552 NA -0.45 -5.97 -0.31 6.09e-9 Diastolic blood pressure; LUSC cis rs7178572 1.000 rs12910361 chr15:77782335 A/G cg22256960 chr15:77711686 NA -0.55 -9.25 -0.45 2.74e-18 Type 2 diabetes; LUSC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.23e-17 Tonsillectomy; LUSC cis rs6546550 0.713 rs6718517 chr2:70018462 T/C cg02498382 chr2:70120550 SNRNP27 -0.26 -6.37 -0.33 6.2e-10 Prevalent atrial fibrillation; LUSC cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg02782426 chr3:40428986 ENTPD3 -0.35 -6.59 -0.34 1.7e-10 Renal cell carcinoma; LUSC cis rs2200578 0.786 rs62158261 chr2:99563210 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 0.62 7.31 0.37 1.93e-12 IgG glycosylation; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg03576123 chr11:487126 PTDSS2 -0.96 -10.59 -0.5 8.69e-23 Body mass index; LUSC cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg12011299 chr4:100065546 ADH4 0.71 11.1 0.52 1.44e-24 Alcohol dependence; LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs11585357 0.895 rs4625336 chr1:17630964 G/T cg08277548 chr1:17600880 PADI3 -0.62 -6.52 -0.34 2.56e-10 Hair shape; LUSC cis rs9457247 0.565 rs2239823 chr6:167512131 T/C cg07741184 chr6:167504864 NA 0.51 8.73 0.43 1.2e-16 Crohn's disease; LUSC cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg15423357 chr2:25149977 NA 0.45 9.13 0.45 6.59e-18 Body mass index; LUSC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -10.09 -0.48 4.63e-21 Developmental language disorder (linguistic errors); LUSC cis rs701145 0.938 rs355770 chr3:154040273 G/A cg17054900 chr3:154042577 DHX36 0.83 8.63 0.43 2.47e-16 Coronary artery disease; LUSC cis rs7681423 1.000 rs2066861 chr4:155527436 C/T cg20735720 chr4:155535218 FGG -0.46 -6.58 -0.34 1.84e-10 Fibrinogen; LUSC cis rs2932538 0.961 rs6690292 chr1:113188419 C/T cg22162597 chr1:113214053 CAPZA1 -0.52 -7.43 -0.38 9.27e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10900049 chr2:8849962 NA 0.4 5.96 0.31 6.55e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5770917 1.000 rs1557503 chr22:51013072 G/A cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.74 -0.3 2.09e-8 Narcolepsy; LUSC trans rs11098499 0.955 rs7684942 chr4:120162201 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.27 0.32 1.09e-9 Corneal astigmatism; LUSC trans rs1325195 0.520 rs2636288 chr1:179227845 T/C cg11624085 chr17:8464688 MYH10 0.45 6.93 0.35 2.18e-11 IgE grass sensitization; LUSC cis rs1975974 0.935 rs41361749 chr17:21732693 A/G cg18423549 chr17:21743878 NA 0.54 8.23 0.41 4.2e-15 Psoriasis; LUSC cis rs2230307 0.572 rs6677080 chr1:100633469 A/T cg24955406 chr1:100503596 HIAT1 0.57 5.9 0.31 9.09e-9 Carotid intima media thickness; LUSC cis rs6012953 0.845 rs968701 chr20:49195248 G/A cg13958625 chr20:49123093 NA -0.27 -5.97 -0.31 6.1e-9 Vitiligo; LUSC cis rs7572644 0.766 rs56046821 chr2:28234701 T/A cg27432699 chr2:27873401 GPN1 -0.52 -6.53 -0.34 2.44e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg02136620 chr5:178986620 RUFY1 0.38 5.86 0.31 1.13e-8 Lung cancer; LUSC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg17366294 chr4:99064904 C4orf37 0.52 9.2 0.45 3.87e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg08200582 chr11:442649 ANO9 -0.53 -6.0 -0.31 5.06e-9 Body mass index; LUSC cis rs765787 0.556 rs2413778 chr15:45539397 C/A cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg16434002 chr17:42200994 HDAC5 0.44 5.98 0.31 5.87e-9 Total body bone mineral density; LUSC cis rs7605827 0.930 rs11691286 chr2:15558580 G/T cg19274914 chr2:15703543 NA 0.46 8.92 0.44 3.15e-17 Educational attainment (years of education); LUSC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 7.33 0.37 1.78e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg22535103 chr8:58192502 C8orf71 -0.76 -7.99 -0.4 2.26e-14 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg11764359 chr7:65958608 NA 0.7 10.95 0.51 4.71e-24 Aortic root size; LUSC cis rs10992471 0.580 rs10992366 chr9:95317214 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.84 -0.35 3.73e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2637266 0.935 rs2579774 chr10:78402253 T/C cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg10018233 chr7:150070692 REPIN1 0.37 6.49 0.33 3.07e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg11812906 chr14:75593930 NEK9 -0.67 -11.56 -0.53 3.21e-26 Height; LUSC cis rs1577917 0.958 rs36042496 chr6:86524214 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs6845621 0.835 rs10005486 chr4:18935783 G/T cg12196642 chr4:18937545 NA -0.36 -6.76 -0.35 6.14e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.52 0.59 1.57e-33 Platelet count; LUSC cis rs3741151 1.000 rs3741151 chr11:73020846 G/T cg17517138 chr11:73019481 ARHGEF17 1.15 9.62 0.47 1.72e-19 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7829975 0.508 rs1594437 chr8:8825875 T/C cg06636001 chr8:8085503 FLJ10661 0.48 7.42 0.38 9.95e-13 Mood instability; LUSC cis rs9581857 0.725 rs9319366 chr13:28017722 C/T cg22138327 chr13:27999177 GTF3A 0.81 9.21 0.45 3.78e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs6430585 0.583 rs9636213 chr2:136589278 G/A cg07169764 chr2:136633963 MCM6 -1.07 -15.97 -0.66 4.53e-43 Corneal structure; LUSC trans rs11098499 0.863 rs10019674 chr4:120443489 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.47 -6.27 -0.32 1.13e-9 Corneal astigmatism; LUSC cis rs9300255 0.639 rs1716171 chr12:123716376 C/T cg00376283 chr12:123451042 ABCB9 0.65 8.3 0.41 2.63e-15 Neutrophil percentage of white cells; LUSC cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg17892150 chr10:133769511 PPP2R2D -0.66 -9.44 -0.46 6.4e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg21775007 chr8:11205619 TDH -0.47 -6.88 -0.35 3.05e-11 Neuroticism; LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs7508679 1.000 rs7508679 chr19:7222832 A/G cg00428638 chr19:7224713 INSR 0.35 7.62 0.38 2.63e-13 Hypothyroidism; LUSC cis rs58235267 0.656 rs13410889 chr2:63087778 T/C cg17519650 chr2:63277830 OTX1 0.71 9.8 0.47 4.13e-20 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg17971929 chr21:40555470 PSMG1 -0.47 -7.13 -0.36 6.08e-12 Menarche (age at onset); LUSC trans rs7939886 0.920 rs17150038 chr11:55863414 A/T cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs1348850 0.874 rs12996447 chr2:178283592 C/T cg22681709 chr2:178499509 PDE11A -0.52 -9.59 -0.46 2.05e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg25767906 chr1:53392781 SCP2 -0.58 -11.28 -0.53 3.33e-25 Monocyte count; LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03576123 chr11:487126 PTDSS2 -0.92 -10.35 -0.49 5.78e-22 Body mass index; LUSC cis rs1788820 0.917 rs4800489 chr18:21125942 A/G cg14672496 chr18:21087552 C18orf8 0.4 6.36 0.33 6.63e-10 Body mass index; LUSC cis rs3126085 0.935 rs1353436 chr1:152172658 G/A cg26876637 chr1:152193138 HRNR 0.45 6.66 0.34 1.16e-10 Atopic dermatitis; LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg02951883 chr7:2050386 MAD1L1 0.37 6.26 0.32 1.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.31 6.25 0.32 1.25e-9 Schizophrenia; LUSC trans rs1997103 1.000 rs2140915 chr7:55410699 G/C cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC cis rs4363385 0.776 rs1890284 chr1:152942190 G/A cg07796016 chr1:152779584 LCE1C -0.46 -6.4 -0.33 5.34e-10 Inflammatory skin disease; LUSC cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg12011299 chr4:100065546 ADH4 0.71 11.07 0.52 1.75e-24 Alcohol dependence; LUSC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg07424592 chr7:64974309 NA -0.69 -6.09 -0.32 3.03e-9 Diabetic kidney disease; LUSC trans rs62103177 0.714 rs28691615 chr18:77612254 C/T cg14227996 chr4:17616232 MED28 0.55 6.19 0.32 1.77e-9 Opioid sensitivity; LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.722 rs12322888 chr12:123825559 A/G cg13010344 chr12:123464640 ARL6IP4 -0.49 -6.44 -0.33 4.06e-10 Neutrophil percentage of white cells; LUSC cis rs9788682 0.747 rs8042374 chr15:78908032 A/G cg24631222 chr15:78858424 CHRNA5 0.62 8.76 0.43 1.01e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.16 0.61 5.72e-36 Platelet count; LUSC cis rs6714710 0.603 rs11678591 chr2:98541001 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.43 0.42 1.04e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6964587 1.000 rs1859037 chr7:91568272 A/G cg17063962 chr7:91808500 NA -0.56 -8.69 -0.43 1.63e-16 Breast cancer; LUSC cis rs7428496 0.528 rs13066441 chr3:142239107 A/C cg16271453 chr3:142027066 XRN1 -0.51 -8.95 -0.44 2.6e-17 Mean corpuscular hemoglobin; LUSC cis rs7605827 0.930 rs13024104 chr2:15603346 T/C cg19274914 chr2:15703543 NA 0.47 9.14 0.45 6.12e-18 Educational attainment (years of education); LUSC cis rs7202877 0.706 rs2059257 chr16:75396376 G/A cg03315344 chr16:75512273 CHST6 0.43 6.35 0.33 7.12e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs16854884 0.632 rs34071449 chr3:143662861 C/T cg06585982 chr3:143692056 C3orf58 0.47 7.24 0.37 3.11e-12 Economic and political preferences (feminism/equality); LUSC cis rs7104764 0.507 rs7111364 chr11:258542 G/C cg00562011 chr11:252351 PSMD13 -0.51 -6.64 -0.34 1.26e-10 Menarche (age at onset); LUSC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg04398451 chr17:18023971 MYO15A 0.5 7.9 0.4 4.04e-14 Total body bone mineral density; LUSC cis rs9420 0.925 rs78587207 chr11:57654991 T/G cg02958346 chr11:57425731 CLP1 -0.45 -6.28 -0.33 1.04e-9 Schizophrenia; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.05 -0.31 3.89e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg13560548 chr3:10150139 C3orf24 0.48 6.6 0.34 1.6e-10 Alzheimer's disease; LUSC cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg15541040 chr2:3486749 NA -0.58 -8.92 -0.44 3.07e-17 Neurofibrillary tangles; LUSC cis rs3770081 1.000 rs78646493 chr2:86283195 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.99 -0.36 1.51e-11 Facial emotion recognition (sad faces); LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.54 -8.32 -0.41 2.27e-15 Lymphocyte counts; LUSC cis rs1580019 0.922 rs1376289 chr7:32486980 C/G cg06627557 chr7:32535165 LSM5;AVL9 -0.78 -10.94 -0.51 5.29e-24 Cognitive ability; LUSC cis rs7824557 0.602 rs11784458 chr8:11204184 G/A cg21775007 chr8:11205619 TDH 0.82 13.75 0.6 2.2e-34 Retinal vascular caliber; LUSC cis rs6918586 0.636 rs198816 chr6:26127184 C/T cg17691542 chr6:26056736 HIST1H1C 0.4 5.95 0.31 6.7e-9 Schizophrenia; LUSC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg12463550 chr7:65579703 CRCP 0.63 5.7 0.3 2.58e-8 Gout; LUSC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg20203395 chr5:56204925 C5orf35 -0.55 -7.5 -0.38 5.88e-13 Type 2 diabetes; LUSC cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg24687543 chr11:63912206 MACROD1 0.46 5.94 0.31 7.22e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC cis rs7200543 0.583 rs4985149 chr16:15147338 A/T cg03427771 chr16:15082598 PDXDC1 -0.41 -5.85 -0.31 1.15e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC trans rs2204008 0.818 rs7313608 chr12:38383428 C/A cg06521331 chr12:34319734 NA 0.39 6.15 0.32 2.17e-9 Bladder cancer; LUSC cis rs12681287 0.640 rs12679811 chr8:87465370 T/C cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs2230307 0.536 rs687513 chr1:100598867 C/T cg24955406 chr1:100503596 HIAT1 -0.64 -6.65 -0.34 1.22e-10 Carotid intima media thickness; LUSC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg10645314 chr2:3704589 ALLC -0.51 -7.75 -0.39 1.14e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs748404 0.697 rs473016 chr15:43558823 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.75 0.3 2.04e-8 Lung cancer; LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.92 -13.66 -0.6 4.71e-34 Alzheimer's disease; LUSC cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.86e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs7726839 0.540 rs61580655 chr5:597564 A/G cg11887960 chr12:57824829 NA 0.54 6.74 0.35 7.11e-11 Obesity-related traits; LUSC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg21285383 chr16:89894308 SPIRE2 0.33 6.76 0.35 6.21e-11 Vitiligo; LUSC cis rs7809950 0.834 rs3801946 chr7:107242995 T/A cg23024343 chr7:107201750 COG5 0.57 9.02 0.44 1.54e-17 Coronary artery disease; LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg16405210 chr4:1374714 KIAA1530 -0.56 -8.68 -0.43 1.73e-16 Obesity-related traits; LUSC cis rs1728785 1.000 rs7192341 chr16:68569224 G/C cg02972257 chr16:68554789 NA -0.5 -6.35 -0.33 7.04e-10 Ulcerative colitis; LUSC cis rs10876993 0.789 rs1689600 chr12:58049645 A/T cg18357645 chr12:58087776 OS9 0.51 7.64 0.39 2.33e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs9527 0.614 rs2153774 chr10:104881035 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.73 -0.3 2.24e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg26314531 chr2:26401878 FAM59B 0.66 8.43 0.42 1.02e-15 Gut microbiome composition (summer); LUSC cis rs3020736 0.500 rs4147641 chr22:42482502 C/G cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs7215564 0.908 rs35071767 chr17:78652575 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs3931020 0.657 rs10890142 chr1:75179129 G/A cg00121533 chr1:75199117 CRYZ;TYW3 0.46 5.76 0.3 1.91e-8 Resistin levels; LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg00814883 chr7:100076585 TSC22D4 -0.75 -10.33 -0.49 7.12e-22 Platelet count; LUSC cis rs2227564 0.620 rs11000787 chr10:75584383 T/C cg23231163 chr10:75533350 FUT11 -0.43 -6.29 -0.33 1.02e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2742234 0.578 rs2742241 chr10:43625223 G/A cg15436174 chr10:43711423 RASGEF1A -0.43 -7.15 -0.36 5.38e-12 Hirschsprung disease; LUSC cis rs734999 0.545 rs41300092 chr1:2537838 C/T cg18932078 chr1:2524107 MMEL1 0.32 7.08 0.36 8.45e-12 Ulcerative colitis; LUSC cis rs9900062 1.000 rs9900062 chr17:62739574 G/A cg02598441 chr17:62777298 LOC146880 -0.61 -6.64 -0.34 1.28e-10 QT interval; LUSC cis rs7772486 0.875 rs1960885 chr6:146325930 G/T cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 9.26e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs11758351 0.660 rs11759904 chr6:26231443 T/C cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg18099408 chr3:52552593 STAB1 -0.36 -6.0 -0.31 5.16e-9 Electroencephalogram traits; LUSC cis rs9790314 1.000 rs336591 chr3:161078080 A/G cg03342759 chr3:160939853 NMD3 -0.48 -8.18 -0.41 5.8e-15 Morning vs. evening chronotype; LUSC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg25456477 chr12:86230367 RASSF9 0.43 7.71 0.39 1.41e-13 Major depressive disorder; LUSC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg17330251 chr7:94953956 PON1 -0.41 -6.63 -0.34 1.35e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1348850 0.793 rs13000048 chr2:178337089 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.16 0.36 5.07e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11612902 chr7:98476174 TRRAP -0.5 -6.1 -0.32 2.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.73 0.65 4.3e-42 Platelet count; LUSC cis rs36051895 0.623 rs6476952 chr9:5236924 T/C cg02405213 chr9:5042618 JAK2 -0.58 -8.42 -0.42 1.12e-15 Pediatric autoimmune diseases; LUSC cis rs9814567 0.712 rs4955545 chr3:134332926 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.62 -0.57 4.01e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7107174 1.000 rs10899478 chr11:78052238 C/T cg02023728 chr11:77925099 USP35 0.44 6.64 0.34 1.3e-10 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.27 -0.32 1.09e-9 Lung cancer; LUSC cis rs9300255 0.568 rs3018098 chr12:123654812 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.35 -0.33 7.01e-10 Neutrophil percentage of white cells; LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.875 rs6570738 chr6:146412695 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.69 -0.34 9.63e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.865 rs10032158 chr4:120391632 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.22e-9 Corneal astigmatism; LUSC cis rs6424115 0.830 rs6672157 chr1:24198840 C/G cg15997130 chr1:24165203 NA 0.52 8.62 0.43 2.63e-16 Immature fraction of reticulocytes; LUSC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg27170947 chr2:26402098 FAM59B 0.71 11.01 0.52 2.92e-24 Gut microbiome composition (summer); LUSC trans rs6952808 0.729 rs35797753 chr7:1954914 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.15 0.32 2.24e-9 Bipolar disorder and schizophrenia; LUSC cis rs3845702 0.736 rs9288045 chr2:180814194 G/A cg01881094 chr2:180872142 CWC22 -1.06 -12.75 -0.57 1.27e-30 Schizophrenia; LUSC cis rs2835872 0.828 rs2835836 chr21:38989187 A/C cg20424643 chr21:39039972 KCNJ6 0.4 6.28 0.32 1.08e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7223966 1.000 rs55674647 chr17:61794195 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.85 0.35 3.5e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg05855489 chr10:104503620 C10orf26 0.63 8.2 0.41 5.12e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs117352156 0.882 rs10826545 chr10:29236395 A/G cg06394621 chr10:29236369 NA 0.43 5.76 0.3 1.87e-8 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs4704187 0.687 rs2335134 chr5:74478843 A/C cg03227963 chr5:74354835 NA 0.29 6.43 0.33 4.38e-10 Response to amphetamines; LUSC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11644478 chr21:40555479 PSMG1 0.89 17.19 0.69 6.71e-48 Cognitive function; LUSC cis rs1577917 1.000 rs13196930 chr6:86652245 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs2832077 0.506 rs10222093 chr21:30163518 T/C cg08807101 chr21:30365312 RNF160 -0.51 -6.86 -0.35 3.36e-11 Cognitive test performance; LUSC cis rs2650000 0.798 rs2701175 chr12:121391671 C/A cg02403541 chr12:121454288 C12orf43 -0.73 -11.19 -0.52 6.81e-25 Metabolic traits;LDL cholesterol; LUSC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg10621924 chr7:39171070 POU6F2 0.5 7.81 0.39 7.37e-14 IgG glycosylation; LUSC cis rs4588572 0.570 rs2362832 chr5:77795843 A/G cg11547950 chr5:77652471 NA -0.57 -8.12 -0.41 9.18e-15 Triglycerides; LUSC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -8.28 -0.41 2.91e-15 Body mass index (adult); LUSC cis rs13006833 0.668 rs291462 chr2:191181678 T/C cg21644426 chr2:191273491 MFSD6 0.43 6.16 0.32 2.13e-9 Urinary metabolites; LUSC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg12463550 chr7:65579703 CRCP 0.51 7.48 0.38 6.42e-13 Aortic root size; LUSC cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg11266682 chr4:10021025 SLC2A9 0.47 8.79 0.43 8.25e-17 Bone mineral density; LUSC cis rs9900062 0.546 rs2676294 chr17:62710764 A/G cg02598441 chr17:62777298 LOC146880 0.52 6.82 0.35 4.39e-11 QT interval; LUSC cis rs7927771 0.524 rs1563821 chr11:47756568 C/T cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg18252515 chr7:66147081 NA -1.19 -12.67 -0.57 2.71e-30 Diabetic kidney disease; LUSC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg26441486 chr22:50317300 CRELD2 0.52 7.95 0.4 2.85e-14 Schizophrenia; LUSC cis rs701145 0.938 rs357504 chr3:153956857 A/C cg17054900 chr3:154042577 DHX36 0.78 8.61 0.43 2.95e-16 Coronary artery disease; LUSC cis rs6977660 0.714 rs10229108 chr7:19824253 G/A cg05791153 chr7:19748676 TWISTNB 0.67 6.98 0.36 1.55e-11 Thyroid stimulating hormone; LUSC cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg17366294 chr4:99064904 C4orf37 0.52 7.39 0.37 1.19e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.534 rs9347170 chr6:167405187 C/T cg23791538 chr6:167370224 RNASET2 0.53 8.86 0.44 4.87e-17 Crohn's disease; LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg22638593 chr5:131593259 PDLIM4 -0.41 -5.82 -0.3 1.39e-8 Blood metabolite levels; LUSC cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg00677455 chr12:58241039 CTDSP2 0.62 9.28 0.45 2.19e-18 Intelligence (multi-trait analysis); LUSC trans rs1493916 0.837 rs11876492 chr18:31413804 T/C cg27147174 chr7:100797783 AP1S1 -0.57 -9.03 -0.44 1.37e-17 Life satisfaction; LUSC cis rs12291225 0.679 rs10832240 chr11:14304744 C/T cg19336497 chr11:14380999 RRAS2 -0.57 -11.8 -0.54 4.27e-27 Sense of smell; LUSC cis rs17155006 0.746 rs402264 chr7:107748337 G/A cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.12 -0.32 2.62e-9 Alzheimer's disease (late onset); LUSC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg04267008 chr7:1944627 MAD1L1 -0.52 -7.74 -0.39 1.18e-13 Schizophrenia; LUSC cis rs9660992 0.548 rs1172152 chr1:205220718 T/A cg21545522 chr1:205238299 TMCC2 0.5 9.48 0.46 4.76e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12973672 0.812 rs10421504 chr19:35764701 C/G cg12095397 chr19:35769544 USF2 0.44 6.67 0.34 1.09e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs3760982 0.565 rs3786956 chr19:44286829 C/T cg21496419 chr19:44306685 LYPD5 0.32 6.72 0.34 8.08e-11 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg16339924 chr4:17578868 LAP3 0.48 7.25 0.37 2.89e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg02423579 chr7:2872169 GNA12 -0.49 -7.0 -0.36 1.39e-11 Height; LUSC cis rs72781680 1.000 rs72796329 chr2:24141912 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs11264799 0.603 rs10489674 chr1:157566019 G/A cg18268488 chr1:157545234 FCRL4 0.33 5.9 0.31 8.76e-9 IgA nephropathy; LUSC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC trans rs372883 0.506 rs2832301 chr21:30749712 G/A cg14791747 chr16:20752902 THUMPD1 -0.41 -5.96 -0.31 6.3e-9 Pancreatic cancer; LUSC trans rs7939886 0.920 rs1481926 chr11:55973281 C/T cg03929089 chr4:120376271 NA 0.82 6.07 0.32 3.41e-9 Myopia (pathological); LUSC cis rs853679 0.527 rs9461443 chr6:28194629 A/T cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.81 -0.3 1.44e-8 Depression; LUSC cis rs6688613 0.694 rs1476347 chr1:166815587 G/T cg07049167 chr1:166818506 POGK 0.55 8.17 0.41 6.32e-15 Refractive astigmatism; LUSC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg02931644 chr1:25747376 RHCE 0.32 5.89 0.31 9.58e-9 Erythrocyte sedimentation rate; LUSC cis rs7586879 0.828 rs4077677 chr2:25122798 G/C cg01884057 chr2:25150051 NA 0.42 8.8 0.43 7.49e-17 Body mass index; LUSC cis rs6690583 0.623 rs1371141 chr1:85455372 C/A cg22153463 chr1:85462885 MCOLN2 0.61 5.91 0.31 8.56e-9 Serum sulfate level; LUSC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg26314531 chr2:26401878 FAM59B -0.66 -9.12 -0.45 7.39e-18 Gut microbiome composition (summer); LUSC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.6 0.46 2.01e-19 Mean platelet volume; LUSC trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg18306943 chr3:40428807 ENTPD3 0.4 6.09 0.32 3.13e-9 Renal cell carcinoma; LUSC cis rs7618501 0.966 rs2352974 chr3:49890613 C/T cg24110177 chr3:50126178 RBM5 -0.47 -7.58 -0.38 3.52e-13 Intelligence (multi-trait analysis); LUSC trans rs57046232 0.552 rs1571216 chr20:6316328 A/C cg21095983 chr6:86352623 SYNCRIP -0.51 -7.58 -0.38 3.38e-13 Colorectal cancer; LUSC cis rs4680 0.737 rs4818 chr22:19951207 C/G cg06346307 chr22:19949965 COMT -0.33 -6.69 -0.34 9.6e-11 Blood metabolite levels; LUSC cis rs6542838 0.553 rs6739503 chr2:99537295 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.17 -0.32 1.96e-9 Fear of minor pain; LUSC cis rs12122100 0.696 rs12733095 chr1:146545741 C/T cg03526459 chr1:146549940 NA -0.41 -6.63 -0.34 1.38e-10 HIV-1 control; LUSC cis rs765787 0.530 rs2554454 chr15:45521536 A/G cg25801113 chr15:45476975 SHF 0.3 6.24 0.32 1.32e-9 Uric acid levels; LUSC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg15485101 chr11:133734466 NA 0.42 7.65 0.39 2.13e-13 Childhood ear infection; LUSC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg05373962 chr22:49881684 NA -0.43 -10.28 -0.49 1.04e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3125734 0.633 rs7100297 chr10:63985100 T/C cg19640130 chr10:64028056 RTKN2 -0.4 -7.07 -0.36 9.11e-12 Rheumatoid arthritis; LUSC cis rs8072100 0.701 rs4794053 chr17:45769551 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.38 -6.32 -0.33 8.47e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg11062466 chr8:58055876 NA 0.48 6.03 0.31 4.34e-9 Developmental language disorder (linguistic errors); LUSC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg02034447 chr16:89574710 SPG7 0.43 6.44 0.33 4.25e-10 Multiple myeloma (IgH translocation); LUSC cis rs9905704 0.609 rs72828712 chr17:56897404 A/T cg12560992 chr17:57184187 TRIM37 0.51 5.87 0.31 1.07e-8 Testicular germ cell tumor; LUSC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg17264618 chr3:40429014 ENTPD3 0.37 7.54 0.38 4.56e-13 Renal cell carcinoma; LUSC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg18252515 chr7:66147081 NA -1.18 -13.0 -0.58 1.52e-31 Diabetic kidney disease; LUSC cis rs6580649 0.941 rs1793933 chr12:48396450 G/T cg24011408 chr12:48396354 COL2A1 0.58 7.76 0.39 1.06e-13 Lung cancer; LUSC cis rs478304 0.651 rs11227281 chr11:65496558 T/C cg05805236 chr11:65401703 PCNXL3 -0.57 -9.25 -0.45 2.79e-18 Acne (severe); LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg02475777 chr4:1388615 CRIPAK 0.44 6.73 0.35 7.29e-11 Longevity; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20796294 chr1:220219430 EPRS -0.53 -6.74 -0.35 7.16e-11 Bipolar disorder and schizophrenia; LUSC cis rs2835872 0.965 rs857947 chr21:39008539 C/T cg20424643 chr21:39039972 KCNJ6 -0.39 -6.03 -0.31 4.26e-9 Electroencephalographic traits in alcoholism; LUSC trans rs7647973 0.626 rs2131108 chr3:49665390 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -6.88 -0.35 2.94e-11 Menarche (age at onset); LUSC cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg26384229 chr12:38710491 ALG10B 0.9 14.1 0.61 9.62e-36 Bladder cancer; LUSC cis rs4499344 0.633 rs166311 chr19:33161246 A/G cg22980127 chr19:33182716 NUDT19 -0.43 -6.38 -0.33 5.77e-10 Mean platelet volume; LUSC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.35 -5.68 -0.3 2.97e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7605827 0.930 rs10929365 chr2:15531626 G/A cg19274914 chr2:15703543 NA 0.48 9.34 0.46 1.39e-18 Educational attainment (years of education); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04184946 chr16:53537260 AKTIP 0.5 6.76 0.35 6.02e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg13531842 chr10:38383804 ZNF37A -0.45 -6.98 -0.36 1.57e-11 Extrinsic epigenetic age acceleration; LUSC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg06656553 chr16:89960601 TCF25 -0.63 -5.7 -0.3 2.68e-8 Skin colour saturation; LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.754 rs1814813 chr4:120258207 G/T cg19731845 chr4:166199412 KLHL2;GK3P -0.42 -6.17 -0.32 1.97e-9 Corneal astigmatism; LUSC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.28 -0.45 2.26e-18 Gut microbiome composition (summer); LUSC cis rs12458462 1.000 rs12458462 chr18:77472436 C/A cg11879182 chr18:77439856 CTDP1 0.72 11.35 0.53 1.79e-25 Monocyte count; LUSC cis rs7267979 1.000 rs3002702 chr20:25268920 T/C cg08601574 chr20:25228251 PYGB 0.43 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg02574844 chr11:5959923 NA -0.44 -6.33 -0.33 7.94e-10 DNA methylation (variation); LUSC cis rs6696846 0.515 rs11240364 chr1:205105917 C/G cg00857998 chr1:205179979 DSTYK 0.47 6.6 0.34 1.57e-10 Red blood cell count; LUSC trans rs9951602 0.512 rs8097996 chr18:76648035 A/G cg02800362 chr5:177631904 HNRNPAB 0.89 13.13 0.58 5.06e-32 Obesity-related traits; LUSC cis rs6465657 0.903 rs11767962 chr7:97778576 C/T cg21770322 chr7:97807741 LMTK2 0.56 10.25 0.49 1.34e-21 Prostate cancer (SNP x SNP interaction);Prostate cancer; LUSC cis rs7647973 0.566 rs57630346 chr3:49086215 T/C cg07636037 chr3:49044803 WDR6 0.92 11.69 0.54 1.1e-26 Menarche (age at onset); LUSC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg03929089 chr4:120376271 NA -0.95 -16.34 -0.67 1.59e-44 Height; LUSC cis rs9359856 0.623 rs1179907 chr6:90324849 A/G cg13799429 chr6:90582589 CASP8AP2 -0.83 -10.41 -0.49 3.79e-22 Bipolar disorder; LUSC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 15.03 0.64 2.39e-39 Platelet count; LUSC cis rs11608355 1.000 rs11611370 chr12:109870291 A/G cg19025524 chr12:109796872 NA 0.36 5.68 0.3 2.87e-8 Neuroticism; LUSC cis rs6076065 0.548 rs1112818 chr20:23323936 G/A cg11657817 chr20:23433608 CST11 0.49 9.75 0.47 6.21e-20 Facial morphology (factor 15, philtrum width); LUSC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg13770153 chr20:60521292 NA -0.68 -9.51 -0.46 3.81e-19 Body mass index; LUSC cis rs12493885 0.818 rs73158491 chr3:153764112 T/C cg17054900 chr3:154042577 DHX36 -0.75 -7.65 -0.39 2.18e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4803468 1.000 rs284656 chr19:41929251 T/C cg09537434 chr19:41945824 ATP5SL -0.93 -16.1 -0.66 1.45e-43 Height; LUSC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg00933542 chr6:150070202 PCMT1 0.3 6.0 0.31 5.27e-9 Lung cancer; LUSC cis rs7296418 0.663 rs11057276 chr12:123820397 C/T cg13010344 chr12:123464640 ARL6IP4 0.48 7.82 0.39 7.01e-14 Platelet count; LUSC cis rs12594515 1.000 rs6493168 chr15:45986811 A/C cg01629716 chr15:45996671 NA 0.4 5.98 0.31 5.77e-9 Waist circumference;Weight; LUSC cis rs1577917 1.000 rs1911552 chr6:86638024 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs644148 0.785 rs118112019 chr19:44965091 T/G cg15540054 chr19:45004280 ZNF180 0.46 6.25 0.32 1.27e-9 Personality dimensions; LUSC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.71 -0.34 8.11e-11 Total body bone mineral density; LUSC cis rs17401966 0.894 rs12141201 chr1:10454714 G/A cg19773385 chr1:10388646 KIF1B -0.57 -9.74 -0.47 6.71e-20 Hepatocellular carcinoma; LUSC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg11584989 chr19:19387371 SF4 0.51 6.5 0.34 2.94e-10 Tonsillectomy; LUSC cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg06784218 chr1:46089804 CCDC17 0.53 11.03 0.52 2.54e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs950169 0.580 rs11633762 chr15:85187152 T/C cg11189052 chr15:85197271 WDR73 0.5 6.43 0.33 4.31e-10 Schizophrenia; LUSC cis rs9611519 0.894 rs9611486 chr22:41458784 C/G cg13813247 chr22:41461852 NA -0.38 -6.79 -0.35 5.18e-11 Neuroticism; LUSC cis rs10779751 0.960 rs1883965 chr1:11322156 A/G cg08854313 chr1:11322531 MTOR 0.85 14.39 0.62 7.28e-37 Body mass index; LUSC cis rs12579753 0.879 rs12829053 chr12:82161926 T/A cg21231944 chr12:82153410 PPFIA2 -0.4 -6.31 -0.33 8.73e-10 Resting heart rate; LUSC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg15839431 chr19:19639596 YJEFN3 0.41 5.89 0.31 9.23e-9 Tonsillectomy; LUSC cis rs1670533 1.000 rs6827357 chr4:1059202 A/C cg27284194 chr4:1044797 NA 0.59 8.26 0.41 3.55e-15 Recombination rate (females); LUSC cis rs17255340 0.511 rs6930990 chr6:84066749 A/C cg08257003 chr6:84140564 ME1 0.35 8.62 0.43 2.66e-16 Platelet-derived growth factor BB levels; LUSC trans rs208520 0.690 rs2797693 chr6:66868985 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.96 -0.68 5.59e-47 Exhaled nitric oxide output; LUSC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg19346786 chr7:2764209 NA -0.48 -8.02 -0.4 1.84e-14 Height; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg24675658 chr1:53192096 ZYG11B -0.62 -10.42 -0.5 3.26e-22 Monocyte count; LUSC cis rs7572644 0.699 rs1902966 chr2:28189280 G/A cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.48 -7.57 -0.38 3.57e-13 Alzheimer's disease (late onset); LUSC cis rs3806843 0.547 rs246054 chr5:140326159 G/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24763869 chr17:3572311 TMEM93;TAX1BP3 0.47 6.98 0.36 1.56e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg23262073 chr20:60523788 NA -0.36 -5.66 -0.3 3.25e-8 Body mass index; LUSC cis rs637571 0.726 rs526631 chr11:65681965 T/G cg17985854 chr11:65770987 BANF1;EIF1AD -0.49 -8.94 -0.44 2.71e-17 Eosinophil percentage of white cells; LUSC cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg24558204 chr6:135376177 HBS1L 0.66 9.89 0.48 2.06e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7208859 0.623 rs59447372 chr17:29057585 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.72 -6.72 -0.35 7.85e-11 Cerebrospinal P-tau181p levels; LUSC cis rs28437878 1 rs28437878 chr15:78807872 C/T cg06917634 chr15:78832804 PSMA4 -0.57 -7.11 -0.36 6.98e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs10432489 0.708 rs4436925 chr2:181755933 T/C cg25678491 chr13:101327172 TMTC4 -0.77 -6.03 -0.31 4.41e-9 QT interval; LUSC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg21862992 chr11:68658383 NA 0.51 8.13 0.41 8.56e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs2204008 0.806 rs11525001 chr12:38234397 A/G cg06521331 chr12:34319734 NA -0.42 -6.58 -0.34 1.82e-10 Bladder cancer; LUSC cis rs6496044 0.568 rs6496065 chr15:86075372 C/T cg13263323 chr15:86062960 AKAP13 -0.37 -6.16 -0.32 2.06e-9 Interstitial lung disease; LUSC cis rs10761482 0.769 rs4948403 chr10:62107662 A/T cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC cis rs10089 0.953 rs4836358 chr5:127376869 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 12.09 0.55 3.72e-28 Ileal carcinoids; LUSC trans rs853679 0.607 rs35902873 chr6:28058949 G/C cg01620082 chr3:125678407 NA -0.87 -7.55 -0.38 4.28e-13 Depression; LUSC cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg21770322 chr7:97807741 LMTK2 0.47 8.03 0.4 1.65e-14 Breast cancer; LUSC cis rs1577917 0.958 rs1816937 chr6:86557251 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg22834771 chr12:69754056 YEATS4 -0.41 -5.79 -0.3 1.6e-8 Blood protein levels; LUSC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.8 10.5 0.5 1.74e-22 Schizophrenia; LUSC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 10.92 0.51 6.12e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9467773 0.838 rs3734540 chr6:26463321 A/C cg09904177 chr6:26538194 HMGN4 0.67 11.34 0.53 2.01e-25 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.45 0.38 8.3e-13 Bipolar disorder; LUSC cis rs7572644 0.760 rs10190494 chr2:28131243 A/G cg27432699 chr2:27873401 GPN1 -0.52 -7.01 -0.36 1.33e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs10791323 0.517 rs1120245 chr11:133745290 A/G cg15485101 chr11:133734466 NA 0.35 6.3 0.33 9.3e-10 Childhood ear infection; LUSC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg00784671 chr22:46762841 CELSR1 -0.63 -7.02 -0.36 1.27e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs2841233 0.681 rs2582558 chr14:105347488 A/G cg16576083 chr14:105354267 KIAA0284 -0.52 -9.06 -0.44 1.13e-17 IgG glycosylation; LUSC cis rs2067615 0.579 rs10861667 chr12:107194776 T/G cg15890332 chr12:107067104 RFX4 0.36 6.57 0.34 1.89e-10 Heart rate; LUSC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg09491104 chr22:46646882 C22orf40 -0.7 -7.46 -0.38 7.57e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs4499344 0.730 rs259286 chr19:33164759 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.83 13.37 0.59 5.94e-33 Mean platelet volume; LUSC cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg12011299 chr4:100065546 ADH4 0.68 10.38 0.49 4.51e-22 Smoking initiation; LUSC cis rs40363 1.000 rs37767 chr16:3514962 C/T cg22508957 chr16:3507546 NAT15 0.84 10.81 0.51 1.45e-23 Tuberculosis; LUSC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg17507749 chr15:85114479 UBE2QP1 0.68 8.58 0.42 3.61e-16 Schizophrenia; LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC cis rs921968 0.540 rs10190250 chr2:219457731 C/T cg02176678 chr2:219576539 TTLL4 -0.76 -14.57 -0.62 1.45e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs9560113 1.000 rs9555810 chr13:112181437 C/G cg14154082 chr13:112174009 NA 0.38 7.88 0.4 4.53e-14 Menarche (age at onset); LUSC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.28 0.53 3.25e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7100689 0.622 rs10749569 chr10:82129892 G/A cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.63e-8 Depression; LUSC cis rs11122272 0.705 rs2486742 chr1:231507254 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.62 -9.69 -0.47 1e-19 Hemoglobin concentration; LUSC cis rs3008870 1.000 rs1925408 chr1:67365034 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.93 15.22 0.64 4.09e-40 Lymphocyte percentage of white cells; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg24341944 chr3:157827791 RSRC1 0.35 6.49 0.33 3.11e-10 Tuberculosis; LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.82 0.3 1.36e-8 Menopause (age at onset); LUSC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg21724239 chr8:58056113 NA 0.55 6.55 0.34 2.19e-10 Developmental language disorder (linguistic errors); LUSC cis rs11039100 0.850 rs11039168 chr11:5844723 C/A cg13902645 chr11:5959945 NA -0.54 -5.99 -0.31 5.41e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg01416388 chr22:39784598 NA -0.46 -7.59 -0.38 3.28e-13 Intelligence (multi-trait analysis); LUSC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg20090143 chr19:45452003 APOC2 0.49 9.61 0.47 1.85e-19 Blood protein levels; LUSC cis rs1385374 0.858 rs10847696 chr12:129297153 G/A cg09035930 chr12:129282057 SLC15A4 -0.62 -6.87 -0.35 3.22e-11 Systemic lupus erythematosus; LUSC cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg01119278 chr6:110721349 DDO 0.48 8.66 0.43 1.99e-16 Platelet distribution width; LUSC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg04727924 chr7:799746 HEATR2 -0.56 -6.66 -0.34 1.15e-10 Cerebrospinal P-tau181p levels; LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg24675658 chr1:53192096 ZYG11B -0.53 -8.33 -0.41 2.14e-15 Monocyte count; LUSC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg07870213 chr5:140052090 DND1 -0.78 -11.61 -0.54 2.04e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg03732007 chr1:2071316 PRKCZ -0.53 -9.47 -0.46 5.17e-19 Height; LUSC cis rs8028313 0.630 rs16951105 chr15:67965694 A/G cg08079166 chr15:68083412 MAP2K5 0.36 6.06 0.31 3.68e-9 Obesity; LUSC trans rs459571 0.959 rs416390 chr9:136908549 C/G cg15028160 chr19:49622717 PPFIA3;C19orf73 0.43 6.18 0.32 1.87e-9 Platelet distribution width; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06876710 chr8:26148870 PPP2R2A 0.77 6.38 0.33 5.84e-10 Cognitive performance; LUSC cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Bone mineral density; LUSC cis rs4629710 0.592 rs67399092 chr6:131582936 G/A cg12700074 chr6:131571435 AKAP7 -0.34 -5.67 -0.3 3.15e-8 Multiple myeloma (IgH translocation); LUSC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg11494091 chr17:61959527 GH2 0.39 6.63 0.34 1.38e-10 Height; LUSC cis rs71403859 0.667 rs12924650 chr16:71705908 C/T cg08717414 chr16:71523259 ZNF19 -0.66 -7.49 -0.38 6.23e-13 Post bronchodilator FEV1; LUSC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg09455208 chr3:40491958 NA 0.58 10.23 0.49 1.51e-21 Renal cell carcinoma; LUSC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.73 0.54 7.94e-27 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7615316 0.934 rs7634158 chr3:142227902 T/C cg16271453 chr3:142027066 XRN1 -0.4 -6.87 -0.35 3.22e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg19717773 chr7:2847554 GNA12 -0.35 -5.66 -0.3 3.23e-8 Height; LUSC cis rs9868809 0.505 rs28567949 chr3:48744560 G/A cg00383909 chr3:49044727 WDR6 1.14 10.32 0.49 7.24e-22 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.53 0.42 5.16e-16 Motion sickness; LUSC cis rs117352156 0.943 rs10826544 chr10:29234961 C/A cg06394621 chr10:29236369 NA -0.44 -5.68 -0.3 2.94e-8 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs11676348 0.783 rs4674252 chr2:218984478 G/A cg06547715 chr2:218990976 CXCR2 0.33 6.5 0.33 3e-10 Ulcerative colitis; LUSC trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg15704280 chr7:45808275 SEPT13 -0.98 -15.8 -0.65 2.19e-42 Height; LUSC cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs8099014 1.000 rs11152073 chr18:56108266 A/T cg12907477 chr18:56117327 MIR122 0.44 7.17 0.37 5.01e-12 Platelet count; LUSC cis rs117352156 0.943 rs17760150 chr10:29213844 A/G cg06394621 chr10:29236369 NA -0.48 -6.44 -0.33 4.06e-10 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg16325326 chr1:53192061 ZYG11B 0.97 18.99 0.72 4.69e-55 Monocyte count; LUSC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg13939156 chr17:80058883 NA -0.33 -6.41 -0.33 4.96e-10 Life satisfaction; LUSC cis rs12220238 0.908 rs73284278 chr10:76011751 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.77 0.35 5.65e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs3540 0.533 rs12916560 chr15:91056259 A/C cg10434728 chr15:90938212 IQGAP1 -0.45 -9.05 -0.44 1.22e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7202877 0.610 rs1010631 chr16:75328590 C/G cg03315344 chr16:75512273 CHST6 0.4 5.84 0.3 1.21e-8 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.36 -7.55 -0.38 4.27e-13 Hemoglobin concentration; LUSC cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg04455712 chr21:45112962 RRP1B 0.48 9.01 0.44 1.6e-17 Mean corpuscular volume; LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg07507251 chr3:52567010 NT5DC2 0.36 7.23 0.37 3.31e-12 Bipolar disorder; LUSC cis rs864537 0.676 rs1773560 chr1:167421763 A/G cg09179987 chr1:167433047 CD247 0.36 5.9 0.31 8.84e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs6542838 0.704 rs56125264 chr2:99516699 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.45 -0.33 3.91e-10 Fear of minor pain; LUSC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg08439880 chr3:133502540 NA -0.33 -5.91 -0.31 8.39e-9 Iron status biomarkers; LUSC cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg03146154 chr1:46216737 IPP 0.52 7.79 0.39 8.3e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3750965 0.806 rs7107680 chr11:68859894 C/T cg06818126 chr11:68850279 TPCN2 -0.45 -6.63 -0.34 1.32e-10 Hair color; LUSC cis rs2901656 0.629 rs10752946 chr1:172376632 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.36 7.29 0.37 2.31e-12 Red cell distribution width;Platelet distribution width; LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg14440974 chr22:39074834 NA -0.37 -6.09 -0.32 3.17e-9 Menopause (age at onset); LUSC cis rs8073060 0.521 rs225254 chr17:33953384 G/A cg05299278 chr17:33885742 SLFN14 0.3 6.23 0.32 1.39e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2364543 0.624 rs61774752 chr1:41847024 T/C cg01193554 chr1:41846683 NA -0.29 -6.07 -0.32 3.52e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.23 -0.49 1.46e-21 Gut microbiome composition (summer); LUSC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg09491104 chr22:46646882 C22orf40 -0.64 -7.38 -0.37 1.3e-12 LDL cholesterol;Cholesterol, total; LUSC trans rs11992162 0.933 rs10108075 chr8:11832079 A/G cg27411982 chr8:10470053 RP1L1 0.51 7.87 0.4 4.87e-14 Monocyte count; LUSC cis rs877282 0.898 rs12356744 chr10:757477 G/C cg17470449 chr10:769945 NA 0.52 6.97 0.36 1.72e-11 Uric acid levels; LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg25767906 chr1:53392781 SCP2 0.71 14.15 0.61 6.14e-36 Monocyte count; LUSC cis rs9796 0.870 rs72737704 chr15:41323575 C/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.99 -0.36 1.51e-11 Menopause (age at onset); LUSC trans rs11250098 0.548 rs7843470 chr8:10784492 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.18 -0.37 4.64e-12 Morning vs. evening chronotype; LUSC cis rs1908814 0.516 rs7812563 chr8:11794488 T/G cg21775007 chr8:11205619 TDH 0.47 6.66 0.34 1.11e-10 Neuroticism; LUSC cis rs240764 0.658 rs9390685 chr6:101224725 A/T cg09795085 chr6:101329169 ASCC3 0.43 6.12 0.32 2.62e-9 Neuroticism; LUSC cis rs508618 0.731 rs11805033 chr1:231546452 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.56 6.83 0.35 4.01e-11 Red blood cell count; LUSC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -7.03 -0.36 1.21e-11 Monocyte percentage of white cells; LUSC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg22963979 chr7:1858916 MAD1L1 -0.5 -7.64 -0.39 2.27e-13 Bipolar disorder and schizophrenia; LUSC cis rs7584330 0.518 rs74003103 chr2:238446699 G/A cg14458575 chr2:238380390 NA 0.58 6.76 0.35 6.35e-11 Prostate cancer; LUSC cis rs11955175 1.000 rs2228058 chr5:40681254 C/T cg05478818 chr5:40835740 RPL37 0.71 5.73 0.3 2.24e-8 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg07606381 chr6:8435919 SLC35B3 0.74 12.57 0.57 6.1e-30 Motion sickness; LUSC cis rs9902453 0.967 rs56129908 chr17:28421382 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.59 0.43 3.35e-16 Coffee consumption (cups per day); LUSC cis rs7580658 0.895 rs4662580 chr2:128102806 C/A cg09760422 chr2:128146352 NA -0.3 -6.36 -0.33 6.57e-10 Protein C levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26439015 chr5:1111863 SLC12A7 -0.39 -6.0 -0.31 5.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10435719 0.580 rs13260712 chr8:11782570 A/C cg15556689 chr8:8085844 FLJ10661 -0.46 -6.76 -0.35 6.16e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2011503 0.509 rs76347963 chr19:19780145 C/T cg11584989 chr19:19387371 SF4 0.51 5.82 0.3 1.41e-8 Bipolar disorder; LUSC cis rs6484504 0.600 rs2616815 chr11:31327316 C/T cg06552810 chr11:31128660 NA 0.39 6.81 0.35 4.65e-11 Red blood cell count; LUSC cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg15557168 chr22:42548783 NA -0.43 -6.76 -0.35 5.99e-11 Schizophrenia; LUSC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg14552801 chr7:65878734 NA 0.37 5.71 0.3 2.49e-8 Aortic root size; LUSC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg16928487 chr17:17741425 SREBF1 -0.42 -8.26 -0.41 3.45e-15 Total body bone mineral density; LUSC cis rs2067615 0.579 rs7297592 chr12:107223969 G/T cg15890332 chr12:107067104 RFX4 0.34 6.02 0.31 4.6e-9 Heart rate; LUSC cis rs3956705 0.762 rs13311608 chr7:32999601 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.5 -7.2 -0.37 4.11e-12 Red cell distribution width; LUSC cis rs8028182 0.525 rs9920028 chr15:75927717 G/A cg20655648 chr15:75932815 IMP3 0.42 5.69 0.3 2.81e-8 Sudden cardiac arrest; LUSC trans rs1941687 0.764 rs4799357 chr18:31366442 T/C cg27147174 chr7:100797783 AP1S1 -0.54 -8.4 -0.42 1.28e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs28595532 0.546 rs17516389 chr4:119239267 T/C cg02775129 chr4:119771670 NA -0.65 -5.69 -0.3 2.83e-8 Cannabis dependence symptom count; LUSC cis rs72901758 0.696 rs72909029 chr17:76249451 A/G cg26068271 chr17:76253126 NA 0.62 10.8 0.51 1.64e-23 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9389248 0.737 rs12664956 chr6:135384188 T/C cg24558204 chr6:135376177 HBS1L 0.69 10.72 0.51 3.17e-23 High light scatter reticulocyte percentage of red cells; LUSC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg24675658 chr1:53192096 ZYG11B 0.76 13.04 0.58 1.07e-31 Monocyte count; LUSC cis rs6120849 0.662 rs6060300 chr20:33780970 T/C cg24642439 chr20:33292090 TP53INP2 0.57 6.17 0.32 1.95e-9 Protein C levels; LUSC cis rs28437878 1 rs28437878 chr15:78807872 C/T cg18825076 chr15:78729989 IREB2 0.46 6.31 0.33 8.94e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs72634258 0.945 rs17367289 chr1:8053135 C/T cg26816564 chr1:7831052 VAMP3 -0.42 -6.01 -0.31 4.78e-9 Inflammatory bowel disease; LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.5e-19 Menopause (age at onset); LUSC cis rs2742417 0.603 rs1468542 chr3:45779136 A/T cg04837898 chr3:45731254 SACM1L 0.45 7.61 0.38 2.89e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs61931739 0.500 rs7977194 chr12:34408459 G/A cg06521331 chr12:34319734 NA -0.4 -6.24 -0.32 1.29e-9 Morning vs. evening chronotype; LUSC cis rs2658782 0.906 rs2658791 chr11:93198983 T/C cg15737290 chr11:93063684 CCDC67 0.68 8.34 0.42 2.01e-15 Pulmonary function decline; LUSC cis rs9359856 0.564 rs56281344 chr6:90445393 T/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.43 -0.42 1.02e-15 Bipolar disorder; LUSC cis rs7605827 0.808 rs13001585 chr2:15517790 T/C cg19274914 chr2:15703543 NA 0.45 8.73 0.43 1.27e-16 Educational attainment (years of education); LUSC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg20891283 chr12:69753455 YEATS4 0.91 17.57 0.69 2.11e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs4319547 0.508 rs10846826 chr12:122894987 C/T cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.33 -0.41 2.13e-15 Body mass index; LUSC cis rs7072216 0.763 rs10883092 chr10:100167276 A/C cg26618903 chr10:100175079 PYROXD2 -0.46 -8.71 -0.43 1.39e-16 Metabolite levels; LUSC cis rs1371867 0.846 rs1660346 chr8:101312497 A/G cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.35e-15 Atrioventricular conduction; LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg25072359 chr17:41440525 NA 0.64 9.06 0.44 1.15e-17 Menopause (age at onset); LUSC cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.4 5.78 0.3 1.68e-8 Schizophrenia; LUSC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg21770322 chr7:97807741 LMTK2 0.42 7.3 0.37 2.08e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs8064299 0.597 rs7210318 chr17:72783385 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.93 19.27 0.73 3.7e-56 Monocyte count; LUSC cis rs73193808 0.639 rs2832248 chr21:30556981 C/T cg03476357 chr21:30257390 N6AMT1 0.46 6.22 0.32 1.5e-9 Coronary artery disease; LUSC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg21856205 chr7:94953877 PON1 -0.35 -5.8 -0.3 1.58e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg23260525 chr10:116636907 FAM160B1 0.49 10.57 0.5 1.02e-22 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs546131 0.963 rs539044 chr11:34841542 G/T cg06937548 chr11:34938143 PDHX;APIP 0.5 7.2 0.37 3.99e-12 Lung disease severity in cystic fibrosis; LUSC cis rs12477438 0.765 rs7591992 chr2:99668954 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs568617 0.859 rs1204650 chr11:65645580 A/C cg04055107 chr11:65626734 MUS81;CFL1 -0.51 -6.14 -0.32 2.39e-9 Crohn's disease; LUSC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg20476274 chr7:133979776 SLC35B4 0.87 16.82 0.68 2e-46 Mean platelet volume; LUSC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg12463550 chr7:65579703 CRCP -0.51 -7.33 -0.37 1.74e-12 Aortic root size; LUSC trans rs7980799 0.682 rs10437795 chr12:33635336 C/G cg13010199 chr12:38710504 ALG10B -0.43 -6.26 -0.32 1.17e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs7939886 0.920 rs1031978 chr11:55965641 G/T cg15704280 chr7:45808275 SEPT13 0.89 6.81 0.35 4.56e-11 Myopia (pathological); LUSC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg08847533 chr14:75593920 NEK9 0.84 15.4 0.64 8.01e-41 Height; LUSC trans rs7647973 0.587 rs10452032 chr3:49680973 G/A cg21659725 chr3:3221576 CRBN -0.68 -7.85 -0.39 5.77e-14 Menarche (age at onset); LUSC cis rs73206853 0.609 rs7306167 chr12:110892449 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7824557 0.564 rs11781637 chr8:11214972 C/T cg21775007 chr8:11205619 TDH -0.7 -11.17 -0.52 8.2e-25 Retinal vascular caliber; LUSC trans rs11933661 0.528 rs1022008 chr4:130966269 C/G cg07526618 chr12:54070131 ATP5G2 0.39 6.18 0.32 1.84e-9 Alcohol dependence; LUSC cis rs2948294 0.588 rs7011221 chr8:8114246 C/T cg06636001 chr8:8085503 FLJ10661 0.74 10.4 0.49 4.1e-22 Red cell distribution width; LUSC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.75 -0.35 6.36e-11 Lung cancer; LUSC cis rs11031096 0.683 rs55898672 chr11:4189284 G/C cg18678763 chr11:4115507 RRM1 -0.41 -5.76 -0.3 1.96e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs750134 0.818 rs55873675 chr12:109034165 T/C cg23338993 chr2:234600423 UGT1A10;UGT1A6;UGT1A9;UGT1A7;UGT1A8 0.45 5.96 0.31 6.54e-9 Low high density lipoprotein cholesterol levels; LUSC trans rs35851103 0.600 rs4841662 chr8:11843758 A/G cg08975724 chr8:8085496 FLJ10661 -0.46 -6.76 -0.35 6.27e-11 Neuroticism; LUSC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg11752832 chr7:134001865 SLC35B4 0.53 7.96 0.4 2.71e-14 Mean platelet volume; LUSC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.16e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11051970 0.879 rs73081911 chr12:32539124 C/G cg02745156 chr12:32552066 NA 0.44 6.99 0.36 1.48e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4629180 0.959 rs11896771 chr2:102098328 T/C cg01388757 chr2:102091195 RFX8 -0.44 -6.88 -0.35 2.97e-11 Chronic rhinosinusitis with nasal polyps; LUSC cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg12011299 chr4:100065546 ADH4 0.7 10.99 0.52 3.46e-24 Alcohol dependence; LUSC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.59 -0.38 3.12e-13 Aortic root size; LUSC cis rs4280164 0.945 rs3181384 chr14:24786976 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.59 -7.22 -0.37 3.54e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg01125463 chr6:42946178 PEX6 -0.36 -5.79 -0.3 1.65e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs8062405 0.755 rs56272201 chr16:28580685 A/G cg07382826 chr16:28625726 SULT1A1 0.28 6.0 0.31 5.18e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs5758659 0.652 rs133330 chr22:42409456 G/A cg15557168 chr22:42548783 NA -0.33 -5.67 -0.3 3.03e-8 Cognitive function; LUSC cis rs9311676 0.632 rs6774357 chr3:58361530 A/C cg26110898 chr3:58419937 PDHB 0.41 6.64 0.34 1.28e-10 Systemic lupus erythematosus; LUSC cis rs13256369 0.802 rs11995449 chr8:8559898 G/A cg06671706 chr8:8559999 CLDN23 0.5 6.47 0.33 3.56e-10 Obesity-related traits; LUSC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg10556349 chr10:835070 NA 0.56 6.23 0.32 1.41e-9 Eosinophil percentage of granulocytes; LUSC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg18876405 chr7:65276391 NA -0.55 -8.78 -0.43 8.51e-17 Aortic root size; LUSC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg12257692 chr3:49977190 RBM6 0.24 6.57 0.34 1.93e-10 Intelligence (multi-trait analysis); LUSC cis rs2797685 1.000 rs2859390 chr1:7847529 A/G cg04725166 chr1:7887271 PER3 -0.44 -5.91 -0.31 8.39e-9 Crohn's disease; LUSC trans rs8002861 0.664 rs9525873 chr13:44482204 T/C cg12856521 chr11:46389249 DGKZ 0.43 6.31 0.33 8.95e-10 Leprosy; LUSC cis rs208520 0.507 rs9453585 chr6:66796668 C/T cg07460842 chr6:66804631 NA -1.23 -26.94 -0.83 9.87e-86 Exhaled nitric oxide output; LUSC cis rs9616064 0.506 rs2073275 chr22:47070432 G/C cg25730555 chr22:47059586 GRAMD4 0.46 7.03 0.36 1.18e-11 Urate levels in obese individuals; LUSC cis rs701145 0.537 rs1727952 chr3:153871565 C/T cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg08847533 chr14:75593920 NEK9 0.83 14.37 0.62 8.46e-37 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27470012 chr16:48643924 N4BP1 -0.4 -5.97 -0.31 6.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs35110281 0.633 rs4819289 chr21:45120237 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.62 10.65 0.5 5.24e-23 Mean corpuscular volume; LUSC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg27633287 chr12:130766243 NA 0.31 5.69 0.3 2.85e-8 Menopause (age at onset); LUSC cis rs7577851 0.672 rs67938413 chr2:69645422 C/T cg10773587 chr2:69614142 GFPT1 0.58 7.05 0.36 1.05e-11 Parkinson's disease (age of onset); LUSC cis rs17270561 0.636 rs6456698 chr6:25741664 A/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs4595586 0.505 rs6580897 chr12:39372254 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.17 0.37 4.75e-12 Morning vs. evening chronotype; LUSC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg26958806 chr6:27640298 NA 0.68 5.76 0.3 1.93e-8 Depression; LUSC trans rs12579753 1.000 rs17692461 chr12:82171755 C/G cg07923666 chr12:49932857 KCNH3 -0.49 -6.09 -0.32 3.05e-9 Resting heart rate; LUSC cis rs7216064 1.000 rs8074078 chr17:65838743 A/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.55 -0.46 2.86e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs8126001 0.548 rs4431000 chr20:62715548 C/A cg03642690 chr20:62727907 OPRL1 -0.33 -5.84 -0.3 1.24e-8 Pulse pressure;Mean corpuscular volume; LUSC cis rs6121246 0.909 rs6058460 chr20:30363071 G/A cg18721089 chr20:30220636 NA -0.35 -6.07 -0.31 3.56e-9 Mean corpuscular hemoglobin; LUSC trans rs877282 0.898 rs10904547 chr10:766283 C/T cg22713356 chr15:30763199 NA 1.08 14.32 0.62 1.3e-36 Uric acid levels; LUSC cis rs1160297 0.576 rs1376567 chr2:53098515 C/G cg07782112 chr2:53107842 NA 0.4 6.48 0.33 3.31e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs7605827 0.930 rs2049718 chr2:15518589 A/G cg19274914 chr2:15703543 NA -0.44 -8.41 -0.42 1.22e-15 Educational attainment (years of education); LUSC cis rs2124969 0.548 rs62175391 chr2:161022588 A/G cg03641300 chr2:160917029 PLA2R1 -0.47 -5.7 -0.3 2.7e-8 Waist circumference adjusted for body mass index; LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 13.92 0.61 4.85e-35 Alzheimer's disease; LUSC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg14784868 chr12:69753453 YEATS4 0.63 9.18 0.45 4.66e-18 Blood protein levels; LUSC cis rs5769707 0.681 rs8137111 chr22:50043750 G/A cg05373962 chr22:49881684 NA -0.41 -8.49 -0.42 6.93e-16 Monocyte count;Monocyte percentage of white cells; LUSC trans rs12200782 1.000 rs72843802 chr6:26517515 C/T cg18180407 chr1:55047736 ACOT11 0.48 5.97 0.31 6.12e-9 Small cell lung carcinoma; LUSC cis rs12474201 0.928 rs12999586 chr2:46938736 C/T cg06386533 chr2:46925753 SOCS5 0.78 11.84 0.54 3.17e-27 Height; LUSC cis rs6723226 0.708 rs2754513 chr2:32782763 G/A cg02381751 chr2:32503542 YIPF4 0.57 8.46 0.42 8.46e-16 Intelligence (multi-trait analysis); LUSC cis rs11625487 0.957 rs10145540 chr14:77957354 C/T cg16049707 chr14:77965284 ISM2 -0.54 -7.54 -0.38 4.36e-13 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs240764 0.658 rs3811078 chr6:101247503 T/C cg09795085 chr6:101329169 ASCC3 -0.46 -6.65 -0.34 1.18e-10 Neuroticism; LUSC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.88 0.48 2.35e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs2392780 0.536 rs377649 chr8:128337241 G/T cg10897648 chr18:56338258 MALT1 -0.42 -6.39 -0.33 5.72e-10 Breast cancer (early onset); LUSC trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg17470723 chr8:74884337 TCEB1 0.52 8.06 0.4 1.33e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -8.99 -0.44 1.83e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs61990749 0.597 rs9788540 chr14:78132172 G/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.57 -6.21 -0.32 1.58e-9 Fibroblast growth factor basic levels; LUSC cis rs2970818 0.731 rs11063170 chr12:4575084 A/T cg11146114 chr12:4671731 NA -0.64 -6.25 -0.32 1.23e-9 Phosphorus levels; LUSC cis rs4595586 0.525 rs1878227 chr12:39355719 A/T cg26384229 chr12:38710491 ALG10B 0.54 7.65 0.39 2.19e-13 Morning vs. evening chronotype; LUSC trans rs7647973 0.592 rs6774202 chr3:49687779 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.89 -0.35 2.86e-11 Menarche (age at onset); LUSC cis rs757081 0.667 rs569780 chr11:17206745 C/T cg15432903 chr11:17409602 KCNJ11 -0.38 -5.85 -0.3 1.18e-8 Systolic blood pressure; LUSC cis rs2658782 0.547 rs3020064 chr11:93060851 A/G cg15737290 chr11:93063684 CCDC67 0.87 13.29 0.59 1.19e-32 Pulmonary function decline; LUSC cis rs34779708 0.931 rs11596502 chr10:35387187 A/C cg04310649 chr10:35416472 CREM -0.43 -6.56 -0.34 1.99e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg20908204 chr19:46285434 DMPK -0.36 -6.71 -0.34 8.2e-11 Coronary artery disease; LUSC cis rs9341808 0.529 rs2322765 chr6:81064596 A/G cg08355045 chr6:80787529 NA 0.44 7.51 0.38 5.6e-13 Sitting height ratio; LUSC cis rs9814567 1.000 rs13081688 chr3:134259954 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.88 0.6 6.88e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1322512 0.917 rs1744377 chr6:152943484 T/C cg27316956 chr6:152958899 SYNE1 -0.36 -5.87 -0.31 1.05e-8 Tonometry; LUSC cis rs10197940 0.624 rs10497081 chr2:152353395 T/G cg19508488 chr2:152266495 RIF1 0.54 7.74 0.39 1.21e-13 Lung cancer; LUSC cis rs9818941 0.955 rs4362677 chr3:157667357 A/G cg08654915 chr3:157813417 NA 0.24 5.85 0.31 1.14e-8 Height; LUSC cis rs11608355 0.846 rs4766471 chr12:109853462 G/A cg05360138 chr12:110035743 NA 0.61 8.19 0.41 5.79e-15 Neuroticism; LUSC cis rs1865721 0.804 rs72977818 chr18:73146852 T/C cg26385618 chr18:73139727 C18orf62 -0.52 -9.62 -0.47 1.71e-19 Intelligence; LUSC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg22535103 chr8:58192502 C8orf71 -0.79 -9.6 -0.46 2.04e-19 Developmental language disorder (linguistic errors); LUSC cis rs983392 0.679 rs603648 chr11:60012673 A/T cg24026212 chr11:59952134 MS4A6A 0.36 6.3 0.33 9.17e-10 Alzheimer's disease (late onset); LUSC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg07870213 chr5:140052090 DND1 0.77 11.42 0.53 9.74e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2637266 1.000 rs12774835 chr10:78352226 C/G cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs72781680 0.898 rs72782138 chr2:24048162 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs782590 0.537 rs7575170 chr2:55886780 C/T cg03859395 chr2:55845619 SMEK2 -0.63 -8.81 -0.43 7.08e-17 Metabolic syndrome; LUSC cis rs10992471 0.639 rs10821008 chr9:95487497 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.34 -0.33 7.67e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg03452623 chr4:187889614 NA -0.88 -18.58 -0.71 2.09e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.07 0.36 9.1e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6961069 0.777 rs1953299 chr7:80265625 T/G cg04458919 chr7:80252533 CD36 0.36 6.45 0.33 3.95e-10 Platelet count; LUSC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg18876405 chr7:65276391 NA 0.58 9.44 0.46 6.57e-19 Aortic root size; LUSC cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg24110177 chr3:50126178 RBM5 0.51 7.98 0.4 2.44e-14 Menarche (age at onset); LUSC cis rs6938 0.597 rs4886641 chr15:75228655 C/A cg17294928 chr15:75287854 SCAMP5 0.43 6.19 0.32 1.81e-9 Breast cancer; LUSC trans rs10432489 0.708 rs6730421 chr2:181755815 A/G cg04744134 chr19:8408128 KANK3 -0.74 -6.14 -0.32 2.33e-9 QT interval; LUSC cis rs8062405 0.723 rs762633 chr16:28608341 T/C cg16576597 chr16:28551801 NUPR1 0.33 6.61 0.34 1.48e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg13683864 chr3:40499215 RPL14 -0.96 -16.8 -0.68 2.35e-46 Renal cell carcinoma; LUSC cis rs4474465 1.000 rs7128417 chr11:78205974 C/G cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC trans rs2832191 0.716 rs2249028 chr21:30365322 G/A cg14791747 chr16:20752902 THUMPD1 -0.42 -6.41 -0.33 4.97e-10 Dental caries; LUSC cis rs6076065 0.723 rs6137924 chr20:23366171 C/G cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs9611565 0.546 rs34077262 chr22:42061639 A/G cg17376030 chr22:41985996 PMM1 -0.44 -5.71 -0.3 2.47e-8 Vitiligo; LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg24060327 chr5:131705240 SLC22A5 -0.53 -8.26 -0.41 3.48e-15 Acylcarnitine levels; LUSC cis rs73195822 0.614 rs11065717 chr12:111208823 A/C cg12870014 chr12:110450643 ANKRD13A 0.65 6.91 0.35 2.49e-11 Itch intensity from mosquito bite; LUSC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg00815214 chr21:47717953 NA 0.37 5.86 0.31 1.13e-8 Testicular germ cell tumor; LUSC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg03188948 chr7:1209495 NA 0.72 8.19 0.41 5.71e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.84 -0.35 3.88e-11 Menopause (age at onset); LUSC trans rs877282 1.000 rs10904552 chr10:774326 A/G cg22713356 chr15:30763199 NA 1.06 15.15 0.64 7.78e-40 Uric acid levels; LUSC cis rs7824557 0.628 rs7815802 chr8:11190647 G/C cg21293242 chr8:11204541 TDH 0.32 6.06 0.31 3.62e-9 Retinal vascular caliber; LUSC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg24209194 chr3:40518798 ZNF619 0.4 5.64 0.3 3.56e-8 Renal cell carcinoma; LUSC trans rs7243066 0.577 rs9957564 chr18:11296178 A/G cg23062198 chr2:14774063 FAM84A -0.47 -6.24 -0.32 1.29e-9 Dental caries; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg21782813 chr7:2030301 MAD1L1 -0.5 -8.37 -0.42 1.56e-15 Bipolar disorder and schizophrenia; LUSC cis rs2236918 0.710 rs2526702 chr1:242017983 G/A cg17736920 chr1:242011382 EXO1 0.43 6.8 0.35 4.79e-11 Menopause (age at onset); LUSC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg06238570 chr21:40685208 BRWD1 -0.57 -8.85 -0.44 5.02e-17 Menarche (age at onset); LUSC cis rs7647973 1.000 rs6446275 chr3:49466871 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.49 -7.45 -0.38 7.92e-13 Menarche (age at onset); LUSC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg13206674 chr6:150067644 NUP43 0.63 10.24 0.49 1.38e-21 Lung cancer; LUSC cis rs7249142 0.561 rs4808185 chr19:19296217 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.4 -6.27 -0.32 1.14e-9 IgG glycosylation; LUSC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg11301795 chr4:187892539 NA -0.8 -15.66 -0.65 7.98e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg22467129 chr15:76604101 ETFA -0.44 -6.88 -0.35 3.01e-11 Blood metabolite levels; LUSC trans rs61931739 0.534 rs10506120 chr12:34235603 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.42 0.42 1.13e-15 Morning vs. evening chronotype; LUSC trans rs61931739 0.927 rs1906135 chr12:34038103 C/A cg26384229 chr12:38710491 ALG10B -0.51 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.58 0.46 2.24e-19 Bipolar disorder; LUSC cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg12011299 chr4:100065546 ADH4 -0.72 -11.25 -0.52 4.13e-25 Alcohol dependence; LUSC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs35264875 1.000 rs72928644 chr11:68849845 A/G cg02660097 chr11:68866761 NA 0.43 6.1 0.32 2.9e-9 Blond vs. brown hair color; LUSC trans rs61931739 0.534 rs7138522 chr12:34039762 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.36 0.42 1.74e-15 Morning vs. evening chronotype; LUSC cis rs897080 0.515 rs1067334 chr2:44626633 A/G cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs2274273 0.682 rs7151224 chr14:55517262 G/A cg04306507 chr14:55594613 LGALS3 0.49 10.52 0.5 1.55e-22 Protein biomarker; LUSC cis rs9420 0.961 rs11605731 chr11:57524089 C/G cg23127183 chr11:57508653 C11orf31 -0.57 -8.81 -0.43 6.86e-17 Schizophrenia; LUSC trans rs853679 0.607 rs66868086 chr6:27865902 A/T cg06606381 chr12:133084897 FBRSL1 -1.03 -8.88 -0.44 4.15e-17 Depression; LUSC cis rs7107174 1.000 rs2511157 chr11:77972632 G/A cg02023728 chr11:77925099 USP35 0.52 7.2 0.37 4.11e-12 Testicular germ cell tumor; LUSC cis rs4930103 0.935 rs4930110 chr11:2026701 G/C cg06197492 chr11:2016605 H19 0.4 6.49 0.33 3.07e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs9467773 0.534 rs34453863 chr6:26628005 T/C cg05738196 chr6:26577821 NA 0.76 13.52 0.59 1.66e-33 Intelligence (multi-trait analysis); LUSC cis rs7824557 0.564 rs11782430 chr8:11226071 A/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.45 -0.33 3.95e-10 Retinal vascular caliber; LUSC cis rs7712401 0.601 rs30027 chr5:122283390 T/C cg19077854 chr5:122220652 SNX24 0.43 9.7 0.47 9.4e-20 Mean platelet volume; LUSC cis rs1577917 0.740 rs7775864 chr6:86247759 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 7.38 0.37 1.24e-12 Response to antipsychotic treatment; LUSC cis rs826838 0.935 rs11169547 chr12:39185625 C/A cg13010199 chr12:38710504 ALG10B 0.69 11.81 0.54 3.94e-27 Heart rate; LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg14004847 chr7:1930337 MAD1L1 -0.53 -8.08 -0.4 1.19e-14 Bipolar disorder and schizophrenia; LUSC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg07636037 chr3:49044803 WDR6 0.45 6.59 0.34 1.72e-10 Resting heart rate; LUSC cis rs8092503 1.000 rs3764515 chr18:52494397 G/T cg12377874 chr18:52495404 RAB27B 0.33 5.99 0.31 5.54e-9 Childhood body mass index; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg05856122 chr11:6633491 TAF10 -0.37 -6.01 -0.31 4.88e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg04455712 chr21:45112962 RRP1B 0.45 8.53 0.42 5.06e-16 Mean corpuscular volume; LUSC trans rs2840044 1.000 rs225259 chr17:33958168 A/G cg19694781 chr19:47549865 TMEM160 -0.58 -9.31 -0.45 1.71e-18 Response to radiotherapy in cancer (late toxicity); LUSC cis rs6867032 1.000 rs4975794 chr5:2015330 A/G cg26168224 chr5:2018326 NA -0.82 -15.82 -0.65 1.77e-42 Gut microbiome composition (winter); LUSC cis rs10911251 0.546 rs2027084 chr1:183110801 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC trans rs3733585 0.725 rs6449201 chr4:9973894 C/T cg26043149 chr18:55253948 FECH -0.46 -7.05 -0.36 1.02e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504073 0.647 rs12549138 chr8:50007203 C/T cg00325661 chr8:49890786 NA 0.62 9.97 0.48 1.15e-20 Blood metabolite ratios; LUSC cis rs7590368 0.683 rs12471762 chr2:10958258 C/T cg15705551 chr2:10952987 PDIA6 0.59 6.36 0.33 6.56e-10 Educational attainment (years of education); LUSC cis rs8078723 0.738 rs8066582 chr17:38146929 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.44 7.23 0.37 3.4e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs12681287 0.673 rs2976178 chr8:87332552 C/G cg27223183 chr8:87520930 FAM82B -0.51 -6.62 -0.34 1.43e-10 Caudate activity during reward; LUSC cis rs7267979 0.966 rs2227892 chr20:25264814 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.49 0.75 5.16e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs887829 0.588 rs4663971 chr2:234674252 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.77 -0.39 9.71e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg13010199 chr12:38710504 ALG10B 0.69 10.76 0.51 2.21e-23 Bladder cancer; LUSC cis rs9326248 0.520 rs1446105 chr11:116798544 C/T cg26566898 chr11:117069891 TAGLN 0.38 7.28 0.37 2.48e-12 Blood protein levels; LUSC cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.09 0.55 3.55e-28 Colorectal cancer; LUSC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Vitiligo; LUSC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.55 0.34 2.18e-10 Menarche (age at onset); LUSC cis rs614226 0.938 rs12857 chr12:120933946 T/G cg27489772 chr12:121021490 NA 0.6 8.03 0.4 1.68e-14 Type 1 diabetes nephropathy; LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg26314531 chr2:26401878 FAM59B 0.74 10.04 0.48 6.81e-21 Gut microbiome composition (summer); LUSC cis rs1172822 0.698 rs2384687 chr19:55831188 A/G cg04391588 chr19:55832610 TMEM150B 0.29 5.77 0.3 1.84e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg03233332 chr7:66118400 NA -0.41 -6.05 -0.31 3.89e-9 Aortic root size; LUSC cis rs2820315 0.867 rs2820323 chr1:201883160 G/A cg10061532 chr1:201886748 LMOD1 0.28 6.44 0.33 4.11e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs7113850 0.541 rs7107940 chr11:24233228 G/A ch.11.24196551F chr11:24239977 NA 0.97 9.05 0.44 1.2e-17 Bone fracture in osteoporosis; LUSC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg06481639 chr22:41940642 POLR3H -0.49 -5.7 -0.3 2.61e-8 Vitiligo; LUSC cis rs9311676 0.632 rs11719192 chr3:58431817 C/G cg13750441 chr3:58318267 PXK 0.35 6.84 0.35 3.88e-11 Systemic lupus erythematosus; LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg07157834 chr1:205819609 PM20D1 0.53 8.68 0.43 1.76e-16 Menarche (age at onset); LUSC cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC cis rs4285028 0.747 rs9808981 chr3:121429561 G/A cg11130432 chr3:121712080 ILDR1 -0.53 -7.79 -0.39 8.81e-14 Multiple sclerosis; LUSC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg20203395 chr5:56204925 C5orf35 -0.56 -8.05 -0.4 1.49e-14 Coronary artery disease; LUSC cis rs11997175 0.740 rs6991071 chr8:33814103 G/A ch.8.33884649F chr8:33765107 NA 0.53 8.17 0.41 6.33e-15 Body mass index; LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg16606324 chr3:10149918 C3orf24 0.59 8.47 0.42 7.78e-16 Alzheimer's disease; LUSC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg03354898 chr7:1950403 MAD1L1 -0.34 -6.9 -0.35 2.62e-11 Bipolar disorder and schizophrenia; LUSC cis rs6457821 1.000 rs56987668 chr6:35319253 T/C cg06087101 chr6:35551932 FKBP5 0.65 5.95 0.31 6.86e-9 Height; LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.31 -0.41 2.42e-15 Gut microbiome composition (summer); LUSC cis rs6733011 0.578 rs10172158 chr2:99509605 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.4 -5.65 -0.3 3.51e-8 Bipolar disorder; LUSC cis rs4891159 0.790 rs72973773 chr18:74115176 T/C cg24786174 chr18:74118243 ZNF516 -0.83 -15.23 -0.64 3.98e-40 Longevity; LUSC cis rs6138458 1.000 rs6114988 chr20:24977586 C/T cg26195577 chr20:24973756 C20orf3 1.11 18.48 0.71 5e-53 Blood protein levels; LUSC trans rs561341 1.000 rs560132 chr17:30320019 C/T cg20587970 chr11:113659929 NA -1.32 -18.36 -0.71 1.51e-52 Hip circumference adjusted for BMI; LUSC trans rs1005277 0.579 rs2474594 chr10:38426661 G/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.64 -0.47 1.41e-19 Extrinsic epigenetic age acceleration; LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg08736216 chr1:53307985 ZYG11A 0.3 6.06 0.31 3.77e-9 Monocyte count; LUSC cis rs10761482 0.954 rs10740022 chr10:62062686 A/G cg18175470 chr10:62150864 ANK3 0.46 6.59 0.34 1.73e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg05340658 chr4:99064831 C4orf37 0.68 11.63 0.54 1.78e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg06808227 chr14:105710500 BRF1 -0.66 -10.21 -0.49 1.82e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs6121246 0.821 rs6058448 chr20:30332396 C/T cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs17270561 0.666 rs17320090 chr6:25720215 C/G cg17691542 chr6:26056736 HIST1H1C 0.56 7.84 0.39 6.1e-14 Iron status biomarkers; LUSC cis rs10791097 0.694 rs4456262 chr11:130755813 C/T cg12179176 chr11:130786555 SNX19 -0.86 -14.47 -0.62 3.42e-37 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6674970 1.000 rs6656450 chr1:151089602 A/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.43 -5.84 -0.3 1.25e-8 Childhood ear infection; LUSC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg21856205 chr7:94953877 PON1 -0.36 -5.72 -0.3 2.32e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs11148252 0.500 rs342768 chr13:53208882 C/T cg02158880 chr13:53174818 NA 0.58 10.12 0.48 3.68e-21 Lewy body disease; LUSC cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg24112000 chr20:60950667 NA -0.43 -8.32 -0.41 2.25e-15 Colorectal cancer; LUSC cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg01689657 chr7:91764605 CYP51A1 0.33 6.0 0.31 5.28e-9 Breast cancer; LUSC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg04287289 chr16:89883240 FANCA 0.57 8.85 0.44 5.02e-17 Vitiligo; LUSC cis rs6818397 1.000 rs6818397 chr4:3434885 A/C cg11522145 chr4:3412961 RGS12 0.29 5.7 0.3 2.68e-8 LDL cholesterol levels;Total cholesterol levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02621988 chr17:2498631 PAFAH1B1 0.38 6.34 0.33 7.52e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9341835 0.772 rs9449233 chr6:64138234 G/T cg00787780 chr6:64151745 NA -0.34 -5.78 -0.3 1.72e-8 Schizophrenia; LUSC cis rs782590 0.620 rs7596377 chr2:55888612 T/A cg03859395 chr2:55845619 SMEK2 -0.71 -10.9 -0.51 6.98e-24 Metabolic syndrome; LUSC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.61e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9790314 0.690 rs6799130 chr3:160847801 C/G cg03342759 chr3:160939853 NMD3 -0.42 -6.83 -0.35 3.91e-11 Morning vs. evening chronotype; LUSC cis rs1832871 0.711 rs9456266 chr6:158714422 A/G cg07165851 chr6:158734300 TULP4 0.5 7.66 0.39 2.05e-13 Height; LUSC cis rs6752107 0.967 rs3792109 chr2:234184417 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.72 11.97 0.55 1.06e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9472414 0.510 rs227845 chr6:44695338 C/A cg20913747 chr6:44695427 NA 0.39 5.79 0.3 1.63e-8 Height; LUSC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg23422044 chr7:1970798 MAD1L1 -0.61 -6.21 -0.32 1.62e-9 Bipolar disorder; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg23142935 chr16:22385308 CDR2 -0.42 -6.74 -0.35 7.08e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6840360 0.593 rs6857073 chr4:152689274 A/G cg22705602 chr4:152727874 NA 0.32 6.77 0.35 5.65e-11 Intelligence (multi-trait analysis); LUSC cis rs7181230 1.000 rs28534747 chr15:40374269 T/C cg00868766 chr15:40364524 NA 0.33 5.69 0.3 2.71e-8 Dehydroepiandrosterone sulphate levels; LUSC cis rs6964587 1.000 rs9691325 chr7:91731047 G/A cg22709100 chr7:91322751 NA 0.4 5.91 0.31 8.61e-9 Breast cancer; LUSC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg04800585 chr6:26043546 HIST1H2BB 0.42 5.97 0.31 6.16e-9 Intelligence (multi-trait analysis); LUSC cis rs7223966 0.655 rs6504165 chr17:61630076 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.4 5.66 0.3 3.27e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7216064 0.953 rs9890629 chr17:65871559 G/A cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7264396 0.943 rs6060448 chr20:34112192 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.38 5.93 0.31 7.58e-9 Total cholesterol levels; LUSC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg07701084 chr6:150067640 NUP43 0.58 8.9 0.44 3.74e-17 Lung cancer; LUSC cis rs5769707 0.681 rs8140095 chr22:50043795 A/G cg05373962 chr22:49881684 NA -0.4 -8.44 -0.42 1.01e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs568617 0.767 rs2231884 chr11:65656564 C/T cg19792802 chr11:65647270 CTSW 0.45 6.53 0.34 2.42e-10 Crohn's disease; LUSC cis rs1728785 1.000 rs698728 chr16:68625253 T/C cg02972257 chr16:68554789 NA -0.51 -6.26 -0.32 1.21e-9 Ulcerative colitis; LUSC cis rs2346177 0.542 rs13020043 chr2:46698431 A/T cg02822958 chr2:46747628 ATP6V1E2 0.47 8.27 0.41 3.14e-15 HDL cholesterol; LUSC cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg07148914 chr20:33460835 GGT7 0.54 8.25 0.41 3.63e-15 Height; LUSC cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.76e-11 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg15704280 chr7:45808275 SEPT13 -0.54 -7.55 -0.38 4.19e-13 HDL cholesterol; LUSC cis rs7572644 0.766 rs12997202 chr2:28250389 A/G cg27432699 chr2:27873401 GPN1 0.52 6.48 0.33 3.22e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6930083 0.713 rs1321308 chr6:36638691 A/C cg08179530 chr6:36648295 CDKN1A -0.56 -8.04 -0.4 1.54e-14 Coronary artery disease; LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg05025164 chr4:1340916 KIAA1530 0.42 6.23 0.32 1.39e-9 Obesity-related traits; LUSC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg12658694 chr1:38397304 INPP5B -0.56 -9.5 -0.46 4.09e-19 Coronary artery disease; LUSC cis rs10504229 0.679 rs2218271 chr8:58052446 T/A cg08219700 chr8:58056026 NA 0.45 5.81 0.3 1.49e-8 Developmental language disorder (linguistic errors); LUSC cis rs9287719 0.967 rs12467642 chr2:10761484 G/A cg00105475 chr2:10696890 NA 0.35 5.92 0.31 7.8e-9 Prostate cancer; LUSC cis rs7799006 0.527 rs6967286 chr7:2212758 C/A cg08027265 chr7:2291960 NA -0.36 -5.93 -0.31 7.56e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg18252515 chr7:66147081 NA -1.19 -12.97 -0.58 2.03e-31 Diabetic kidney disease; LUSC cis rs1451375 0.698 rs11238214 chr7:50636018 A/G cg18232548 chr7:50535776 DDC 0.51 7.76 0.39 1.01e-13 Malaria; LUSC trans rs35110281 0.807 rs2838325 chr21:45014284 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.57 -9.7 -0.47 8.87e-20 Mean corpuscular volume; LUSC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg25809561 chr17:30822961 MYO1D 0.47 8.37 0.42 1.56e-15 Schizophrenia; LUSC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg08270630 chr22:50330655 NA -0.4 -6.07 -0.32 3.4e-9 Schizophrenia; LUSC trans rs877282 0.853 rs11595510 chr10:756757 C/G cg22713356 chr15:30763199 NA 0.99 13.29 0.59 1.19e-32 Uric acid levels; LUSC cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg00071950 chr4:10020882 SLC2A9 0.5 7.88 0.4 4.77e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1355223 0.583 rs1396881 chr11:34870506 G/T cg24088639 chr11:34937564 PDHX;APIP -0.46 -6.84 -0.35 3.81e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11676855 0.893 rs6431329 chr2:235934338 C/T cg14917874 chr2:235941519 SH3BP4 0.51 8.68 0.43 1.81e-16 Dialysis-related mortality; LUSC cis rs9818758 0.545 rs9853352 chr3:49813258 C/T cg00383909 chr3:49044727 WDR6 -1.03 -9.66 -0.47 1.23e-19 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC trans rs7824557 0.527 rs4634600 chr8:11239017 T/A cg15556689 chr8:8085844 FLJ10661 -0.47 -7.29 -0.37 2.2e-12 Retinal vascular caliber; LUSC cis rs9646944 0.501 rs10172116 chr2:103087573 C/T cg20060108 chr2:102954350 IL1RL1 0.44 5.87 0.31 1.07e-8 Blood protein levels; LUSC cis rs9462027 0.606 rs2395606 chr6:34778486 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg24250549 chr1:154909240 PMVK -0.57 -9.15 -0.45 5.95e-18 Prostate cancer; LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg08677398 chr8:58056175 NA 0.51 6.75 0.35 6.43e-11 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20149956 chr1:249132233 ZNF672 -0.52 -6.72 -0.35 7.99e-11 Bipolar disorder and schizophrenia; LUSC trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg15704280 chr7:45808275 SEPT13 -0.84 -11.72 -0.54 8.17e-27 Coronary artery disease; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg10802521 chr3:52805072 NEK4 -0.53 -8.05 -0.4 1.45e-14 Bipolar disorder; LUSC cis rs865483 0.861 rs1063215 chr17:35874936 A/G cg06716730 chr17:35851459 DUSP14 0.26 5.87 0.31 1.05e-8 Monocyte count; LUSC cis rs1559088 1.000 rs2161225 chr19:33551899 C/T cg27124370 chr19:33622961 WDR88 0.52 6.66 0.34 1.14e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7769051 1.000 rs3813347 chr6:133119778 G/A cg07930552 chr6:133119739 C6orf192 0.85 10.66 0.5 5.07e-23 Type 2 diabetes nephropathy; LUSC cis rs3806843 1.000 rs991918 chr5:140194858 C/T cg19875535 chr5:140030758 IK 0.44 6.96 0.36 1.8e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs1549118 0.595 rs28613643 chr14:78332161 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.43 -5.74 -0.3 2.16e-8 Resting heart rate; LUSC trans rs403814 0.938 rs3898848 chr18:6294119 C/T cg05469346 chr5:174115696 NA -0.44 -6.1 -0.32 2.9e-9 Hypertension; LUSC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg24399712 chr22:39784796 NA -0.58 -9.26 -0.45 2.6e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg23711669 chr6:146136114 FBXO30 0.87 15.93 0.66 6.54e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7605378 1.000 rs2577852 chr2:200687248 C/T cg23649088 chr2:200775458 C2orf69 0.49 7.4 0.38 1.15e-12 Osteoporosis; LUSC cis rs870825 0.587 rs35845099 chr4:185639762 A/G cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs10782582 0.593 rs114421765 chr1:76141802 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.38 -0.33 5.86e-10 Daytime sleep phenotypes; LUSC cis rs11690935 0.885 rs6725388 chr2:172730015 G/C cg13550731 chr2:172543902 DYNC1I2 -0.82 -13.23 -0.59 1.99e-32 Schizophrenia; LUSC trans rs3858145 0.588 rs61854837 chr10:70042370 C/G cg04882175 chr6:131122610 NA -0.67 -8.42 -0.42 1.09e-15 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg20503657 chr10:835505 NA 0.51 7.01 0.36 1.35e-11 Response to angiotensin II receptor blocker therapy; LUSC trans rs7939886 0.844 rs12421584 chr11:55937410 G/A cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC cis rs1448094 0.617 rs2221319 chr12:86468064 C/A cg00310523 chr12:86230176 RASSF9 -0.35 -6.27 -0.32 1.14e-9 Major depressive disorder; LUSC cis rs7828089 0.582 rs3817445 chr8:22266054 G/T cg12081754 chr8:22256438 SLC39A14 0.76 11.87 0.54 2.28e-27 Verbal declarative memory; LUSC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg03433033 chr1:76189801 ACADM 0.82 13.38 0.59 5.26e-33 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7582180 0.629 rs7597615 chr2:100954828 T/C cg08017756 chr2:100939284 LONRF2 -0.47 -8.64 -0.43 2.36e-16 Intelligence (multi-trait analysis); LUSC cis rs7954584 0.635 rs7309024 chr12:122338334 C/T cg01765077 chr12:122356316 WDR66 0.51 7.38 0.37 1.28e-12 Mean corpuscular volume; LUSC cis rs3820068 0.608 rs9660255 chr1:16031891 T/G cg13390004 chr1:15929781 NA 0.41 6.79 0.35 5.02e-11 Systolic blood pressure; LUSC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg00033643 chr7:134001901 SLC35B4 0.47 7.35 0.37 1.53e-12 Mean platelet volume; LUSC cis rs734999 0.588 rs11585048 chr1:2534087 C/T cg18932078 chr1:2524107 MMEL1 0.33 7.31 0.37 2.03e-12 Ulcerative colitis; LUSC cis rs3820928 1.000 rs1346618 chr2:227771988 C/T cg11843606 chr2:227700838 RHBDD1 0.51 7.59 0.38 3.19e-13 Pulmonary function; LUSC cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg03264133 chr6:25882463 NA -0.5 -9.14 -0.45 6.03e-18 Blood metabolite levels; LUSC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg26597838 chr10:835615 NA 0.99 13.98 0.61 2.67e-35 Eosinophil percentage of granulocytes; LUSC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -5.73 -0.3 2.2e-8 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.771 rs4145082 chr6:86352016 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.86 -0.44 4.7e-17 Response to antipsychotic treatment; LUSC cis rs9473147 0.516 rs9381579 chr6:47556680 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.75 0.3 2.07e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg00945038 chr17:61921165 SMARCD2 -0.52 -9.15 -0.45 5.79e-18 Prudent dietary pattern; LUSC cis rs753778 0.559 rs2288997 chr8:142200731 A/G cg18755752 chr8:142205143 DENND3 0.62 9.09 0.45 8.84e-18 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs3749237 0.964 rs1799845 chr3:49847623 A/G cg03060546 chr3:49711283 APEH 0.57 8.11 0.41 9.92e-15 Resting heart rate; LUSC cis rs11051970 0.636 rs2651368 chr12:32561506 T/C cg02745156 chr12:32552066 NA 0.37 6.82 0.35 4.3e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg20821713 chr7:1055600 C7orf50 -0.58 -7.76 -0.39 1.04e-13 Bronchopulmonary dysplasia; LUSC cis rs981844 0.712 rs921882 chr4:154752878 A/C cg14289246 chr4:154710475 SFRP2 -0.46 -6.3 -0.33 9.19e-10 Response to statins (LDL cholesterol change); LUSC cis rs8099014 0.816 rs8099343 chr18:56110071 C/T cg12907477 chr18:56117327 MIR122 0.44 7.02 0.36 1.28e-11 Platelet count; LUSC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg06481639 chr22:41940642 POLR3H -0.54 -5.97 -0.31 6.16e-9 Vitiligo; LUSC cis rs9341835 0.772 rs9294196 chr6:64135193 A/G cg00787780 chr6:64151745 NA 0.34 5.77 0.3 1.81e-8 Schizophrenia; LUSC cis rs8016982 0.674 rs1951614 chr14:81672106 A/G cg01989461 chr14:81687754 GTF2A1 -0.73 -13.24 -0.59 1.88e-32 Schizophrenia; LUSC cis rs9837602 1.000 rs62285478 chr3:99822135 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.31 0.33 8.81e-10 Breast cancer; LUSC cis rs250677 0.522 rs56309414 chr5:148376026 C/G cg18129178 chr5:148520854 ABLIM3 -0.5 -7.29 -0.37 2.21e-12 Breast cancer; LUSC trans rs11039798 0.920 rs8186465 chr11:48796771 T/C cg03929089 chr4:120376271 NA 0.72 6.77 0.35 5.71e-11 Axial length; LUSC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11890956 chr21:40555474 PSMG1 1.0 18.55 0.71 2.64e-53 Cognitive function; LUSC cis rs7712401 0.601 rs154502 chr5:122207046 C/T cg19077854 chr5:122220652 SNX24 0.42 9.66 0.47 1.26e-19 Mean platelet volume; LUSC cis rs425277 1.000 rs262676 chr1:2078482 T/A cg24578937 chr1:2090814 PRKCZ 0.6 13.63 0.6 6e-34 Height; LUSC cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg27279351 chr12:120934652 DYNLL1 0.59 7.88 0.4 4.54e-14 High light scatter reticulocyte count; LUSC cis rs2730245 0.527 rs1188974 chr7:158665748 C/T cg11984989 chr7:158649758 WDR60 1.11 13.54 0.6 1.3e-33 Height; LUSC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.16 0.49 2.64e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23409613 chr14:53196849 STYX -0.5 -6.14 -0.32 2.29e-9 Bipolar disorder and schizophrenia; LUSC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg15468180 chr1:107600409 PRMT6 0.38 6.02 0.31 4.53e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.02 -0.31 4.49e-9 Platelet count; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg10150615 chr22:24372951 LOC391322 -0.43 -7.23 -0.37 3.22e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg15744005 chr10:104629667 AS3MT -0.28 -5.93 -0.31 7.63e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1775715 0.737 rs2799018 chr10:32202069 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.76 0.35 6.05e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9810089 0.967 rs7372313 chr3:135872958 G/C cg12473912 chr3:136751656 NA 0.33 5.68 0.3 3.01e-8 Gestational age at birth (child effect); LUSC cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg11244672 chr19:19639970 YJEFN3 0.61 7.59 0.38 3.3e-13 Bipolar disorder; LUSC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg25174290 chr11:3078921 CARS 0.59 8.94 0.44 2.79e-17 Longevity; LUSC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11644478 chr21:40555479 PSMG1 0.94 18.89 0.72 1.15e-54 Cognitive function; LUSC cis rs3020736 0.500 rs6002616 chr22:42504679 A/G cg04733989 chr22:42467013 NAGA -0.62 -9.72 -0.47 7.81e-20 Autism spectrum disorder or schizophrenia; LUSC trans rs1486139 1.000 rs6463322 chr7:46283138 T/C cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.03 -0.31 4.28e-9 Platelet count; LUSC cis rs11690935 0.959 rs6433314 chr2:172660971 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.59 -0.62 1.21e-37 Schizophrenia; LUSC trans rs11992162 0.551 rs13268217 chr8:11782609 T/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.41 -0.33 5.05e-10 Monocyte count; LUSC cis rs597583 0.715 rs1940040 chr11:117393294 G/C cg27161313 chr11:117392002 DSCAML1 -0.51 -8.53 -0.42 4.99e-16 Putamen volume; LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.05 -14.99 -0.63 3.24e-39 Gut microbiome composition (summer); LUSC cis rs7845219 0.539 rs10441538 chr8:95868608 G/A cg23172400 chr8:95962367 TP53INP1 -0.3 -5.97 -0.31 6.08e-9 Type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25198656 chr7:5013641 RNF216L -0.53 -6.09 -0.32 3.04e-9 Bipolar disorder and schizophrenia; LUSC cis rs12579753 1.000 rs7966755 chr12:82221604 A/G cg21231944 chr12:82153410 PPFIA2 -0.4 -6.03 -0.31 4.39e-9 Resting heart rate; LUSC trans rs12200782 1.000 rs12201802 chr6:26398664 G/A cg11837749 chr1:55047332 ACOT11 0.59 6.15 0.32 2.19e-9 Small cell lung carcinoma; LUSC cis rs6940638 0.662 rs7759694 chr6:27240956 C/T cg05738196 chr6:26577821 NA -0.45 -6.58 -0.34 1.87e-10 Intelligence (multi-trait analysis); LUSC trans rs4332037 0.901 rs11767040 chr7:1945468 C/T cg11693508 chr17:37793320 STARD3 0.66 8.07 0.4 1.27e-14 Bipolar disorder; LUSC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg26441486 chr22:50317300 CRELD2 0.53 8.07 0.4 1.27e-14 Schizophrenia; LUSC cis rs7119 0.679 rs12914932 chr15:77839051 G/A cg27398640 chr15:77910606 LINGO1 -0.32 -6.5 -0.34 2.87e-10 Type 2 diabetes; LUSC cis rs1728785 1.000 rs821167 chr16:68577222 T/G cg02972257 chr16:68554789 NA -0.49 -6.35 -0.33 7.09e-10 Ulcerative colitis; LUSC cis rs367615 0.537 rs431669 chr5:108663115 G/A cg17395555 chr5:108820864 NA 0.55 9.62 0.47 1.72e-19 Colorectal cancer (SNP x SNP interaction); LUSC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg03929089 chr4:120376271 NA -1.03 -19.82 -0.74 2.49e-58 Height; LUSC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -11.25 -0.52 4.05e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9788682 0.747 rs16969894 chr15:78776456 C/T cg06917634 chr15:78832804 PSMA4 -0.49 -6.02 -0.31 4.58e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.55 -6.95 -0.36 1.98e-11 Chronic sinus infection; LUSC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg11247378 chr22:39784982 NA -0.65 -13.23 -0.59 2.05e-32 Intelligence (multi-trait analysis); LUSC cis rs2635047 0.811 rs17723754 chr18:44771481 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.93 0.31 7.62e-9 Educational attainment; LUSC cis rs4499344 0.664 rs7258278 chr19:33099523 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.91 0.58 3.4e-31 Mean platelet volume; LUSC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg20302533 chr7:39170763 POU6F2 0.55 9.19 0.45 4.35e-18 IgG glycosylation; LUSC trans rs2299682 0.826 rs16995976 chr20:9482637 C/T cg16619378 chr17:14207530 HS3ST3B1;MGC12916 -0.6 -6.0 -0.31 5.09e-9 Initial pursuit acceleration;Initial pursuit acceleration in psychotic disorders; LUSC cis rs9393777 0.844 rs72839477 chr6:27327000 C/T cg09904177 chr6:26538194 HMGN4 -0.78 -5.74 -0.3 2.12e-8 Intelligence (multi-trait analysis); LUSC cis rs7119 0.717 rs11629652 chr15:77779951 C/A cg27398640 chr15:77910606 LINGO1 -0.28 -5.81 -0.3 1.42e-8 Type 2 diabetes; LUSC trans rs11098499 0.954 rs7654587 chr4:120388406 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.12 0.32 2.57e-9 Corneal astigmatism; LUSC cis rs3768617 0.510 rs1547712 chr1:183088013 T/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg14298792 chr15:30685198 CHRFAM7A -0.69 -8.87 -0.44 4.43e-17 Huntington's disease progression; LUSC cis rs9420 0.884 rs589914 chr11:57661032 A/G cg23127183 chr11:57508653 C11orf31 0.51 7.22 0.37 3.44e-12 Schizophrenia; LUSC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg22437258 chr11:111473054 SIK2 0.54 7.68 0.39 1.75e-13 Primary sclerosing cholangitis; LUSC cis rs7681423 1.000 rs2066854 chr4:155535181 T/A cg20735720 chr4:155535218 FGG -0.47 -6.84 -0.35 3.79e-11 Fibrinogen; LUSC cis rs6964587 1.000 rs35317449 chr7:91637010 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.6e-8 Breast cancer; LUSC cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg02228329 chr11:64053129 BAD;GPR137 0.43 6.07 0.32 3.4e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs9811920 0.893 rs9814549 chr3:99892190 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -6.18 -0.32 1.88e-9 Axial length; LUSC cis rs7538876 0.903 rs1324368 chr1:17752000 A/G cg07965774 chr1:17746286 RCC2 0.33 6.23 0.32 1.37e-9 Basal cell carcinoma; LUSC trans rs6502050 0.835 rs8071737 chr17:80117537 T/C cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.46e-10 Life satisfaction; LUSC cis rs10754283 0.967 rs10754285 chr1:90116587 A/G cg21401794 chr1:90099060 LRRC8C 0.48 6.27 0.32 1.1e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.54 -0.34 2.32e-10 Bipolar disorder and schizophrenia; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg03354898 chr7:1950403 MAD1L1 0.43 8.83 0.44 6.05e-17 Bipolar disorder and schizophrenia; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg00106254 chr7:1943704 MAD1L1 -0.4 -5.74 -0.3 2.09e-8 Bipolar disorder and schizophrenia; LUSC cis rs7267979 1.000 rs6083856 chr20:25407585 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.78 -0.7 2.97e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg22920501 chr2:26401640 FAM59B 0.77 11.26 0.52 3.73e-25 Gut microbiome composition (summer); LUSC trans rs8072100 0.727 rs4794052 chr17:45769236 T/C cg03886242 chr7:26192032 NFE2L3 -0.41 -6.26 -0.32 1.22e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8014204 0.935 rs3742786 chr14:75373011 A/G cg06637938 chr14:75390232 RPS6KL1 -0.66 -11.21 -0.52 5.47e-25 Caffeine consumption; LUSC cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg21535247 chr6:8435926 SLC35B3 0.6 9.46 0.46 5.68e-19 Motion sickness; LUSC cis rs11030122 0.661 rs4910877 chr11:4062153 A/G cg18678763 chr11:4115507 RRM1 -0.42 -5.66 -0.3 3.19e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg18252515 chr7:66147081 NA 1.26 14.54 0.62 1.94e-37 Gout; LUSC cis rs6750047 0.609 rs2121259 chr2:38269475 T/C cg07380506 chr2:38303506 CYP1B1 0.44 6.03 0.31 4.26e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg01125463 chr6:42946178 PEX6 -0.36 -5.97 -0.31 6.19e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs765787 0.530 rs4514617 chr15:45535439 A/G cg25801113 chr15:45476975 SHF 0.32 6.44 0.33 4.13e-10 Uric acid levels; LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC cis rs12545109 0.765 rs2576589 chr8:57425647 C/T cg09654669 chr8:57350985 NA -0.49 -6.01 -0.31 4.77e-9 Obesity-related traits; LUSC cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.11e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs6906287 0.669 rs2184402 chr6:118935341 T/C cg21191810 chr6:118973309 C6orf204 0.32 5.91 0.31 8.23e-9 Electrocardiographic conduction measures; LUSC trans rs877282 0.853 rs7079450 chr10:755932 T/A cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs2898290 0.500 rs11998678 chr8:11830150 A/G cg21775007 chr8:11205619 TDH -0.49 -7.03 -0.36 1.21e-11 Systolic blood pressure; LUSC cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg01028140 chr2:1542097 TPO -0.37 -5.97 -0.31 6.12e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.56 -0.5 1.14e-22 Schizophrenia; LUSC cis rs72781680 0.851 rs12612830 chr2:24134599 C/T cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC trans rs7824557 0.564 rs7821459 chr8:11236681 T/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.66e-10 Retinal vascular caliber; LUSC cis rs7312933 0.592 rs1551210 chr12:42865874 C/T cg01256987 chr12:42539512 GXYLT1 -0.38 -7.11 -0.36 7.07e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs2262909 0.962 rs73019842 chr19:22249909 T/G cg17074339 chr11:11642133 GALNTL4 0.47 7.17 0.37 4.94e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs765787 0.530 rs11639403 chr15:45538350 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs6547741 0.904 rs2384659 chr2:27856793 G/A cg27432699 chr2:27873401 GPN1 0.79 14.44 0.62 4.64e-37 Oral cavity cancer; LUSC cis rs35146811 0.735 rs858512 chr7:99824453 A/G cg22906224 chr7:99728672 NA -0.5 -6.94 -0.35 2.09e-11 Coronary artery disease; LUSC cis rs950776 0.518 rs1979907 chr15:78842239 T/C cg22563815 chr15:78856949 CHRNA5 -0.26 -6.26 -0.32 1.21e-9 Sudden cardiac arrest; LUSC cis rs4253772 0.938 rs41329344 chr22:46636930 C/T cg09491104 chr22:46646882 C22orf40 -0.62 -6.62 -0.34 1.47e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs6460942 0.591 rs7800823 chr7:12378697 G/T cg06484146 chr7:12443880 VWDE -0.46 -6.14 -0.32 2.37e-9 Coronary artery disease; LUSC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.92 0.66 7.28e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16410656 chr11:35965504 LDLRAD3 -0.46 -6.04 -0.31 4.22e-9 Bipolar disorder and schizophrenia; LUSC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg10523679 chr1:76189770 ACADM 0.85 11.36 0.53 1.62e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7089973 0.624 rs11196930 chr10:116583596 C/T cg23260525 chr10:116636907 FAM160B1 0.43 9.14 0.45 6.18e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6500395 0.962 rs9921737 chr16:48589873 G/T cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.94e-9 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs2665103 0.715 rs7403041 chr15:82580182 A/C cg18393722 chr15:85113863 UBE2QP1 0.45 7.03 0.36 1.17e-11 Intelligence (multi-trait analysis); LUSC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg21963583 chr11:68658836 MRPL21 0.56 8.66 0.43 2.09e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.18 0.77 1.27e-67 Prudent dietary pattern; LUSC cis rs4443100 0.792 rs9612223 chr22:23389142 T/G cg21100191 chr22:23484243 RTDR1 0.55 6.6 0.34 1.62e-10 Serum parathyroid hormone levels; LUSC cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg18758796 chr5:131593413 PDLIM4 0.44 7.44 0.38 8.46e-13 Breast cancer; LUSC cis rs7605827 0.930 rs9287664 chr2:15597116 A/G cg19274914 chr2:15703543 NA -0.48 -9.42 -0.46 7.41e-19 Educational attainment (years of education); LUSC cis rs870825 0.860 rs2705895 chr4:185598404 C/T cg04058563 chr4:185651563 MLF1IP -0.79 -12.08 -0.55 4.06e-28 Blood protein levels; LUSC cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg05738196 chr6:26577821 NA 0.48 7.04 0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7949030 1.000 rs3018561 chr11:62392229 C/A cg11742103 chr11:62369870 EML3;MTA2 -0.48 -8.08 -0.4 1.23e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2439831 0.867 rs2260160 chr15:43895643 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.85 9.26 0.45 2.48e-18 Lung cancer in ever smokers; LUSC trans rs6089829 0.962 rs6011544 chr20:61658782 T/C cg17470723 chr8:74884337 TCEB1 0.5 7.38 0.37 1.23e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg02772935 chr3:125709198 NA -0.48 -5.81 -0.3 1.49e-8 Blood pressure (smoking interaction); LUSC trans rs9929218 0.953 rs3114411 chr16:68734591 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.81 12.12 0.55 2.97e-28 Colorectal cancer; LUSC cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg23583168 chr7:148888333 NA -0.88 -16.78 -0.68 2.87e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs870825 0.616 rs28459754 chr4:185636280 C/A cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC cis rs11190604 0.767 rs4919458 chr10:102177728 G/A cg07080220 chr10:102295463 HIF1AN -0.55 -7.76 -0.39 1.07e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9303280 0.901 rs12936231 chr17:38029120 C/G cg20243544 chr17:37824526 PNMT 0.39 6.11 0.32 2.75e-9 Self-reported allergy; LUSC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg15145296 chr3:125709740 NA -0.58 -6.41 -0.33 4.91e-10 Blood pressure (smoking interaction); LUSC cis rs8017423 0.935 rs11621820 chr14:90727154 C/T cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs911119 1.000 rs6036476 chr20:23610308 C/G cg16589663 chr20:23618590 CST3 0.59 6.95 0.36 1.88e-11 Chronic kidney disease; LUSC cis rs6494488 0.500 rs111858590 chr15:65063622 C/A cg08069370 chr15:64387884 SNX1 -0.65 -5.85 -0.31 1.15e-8 Coronary artery disease; LUSC cis rs3931020 0.508 rs2345436 chr1:75198740 A/C cg17719053 chr1:75198211 TYW3;CRYZ 0.39 5.69 0.3 2.78e-8 Resistin levels; LUSC cis rs9807989 0.507 rs6755905 chr2:103048207 C/A cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.98e-12 Asthma; LUSC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg24250549 chr1:154909240 PMVK 0.66 11.1 0.52 1.36e-24 Prostate cancer; LUSC cis rs1552244 0.507 rs6443274 chr3:9995288 A/T cg08888203 chr3:10149979 C3orf24 0.46 7.0 0.36 1.41e-11 Alzheimer's disease; LUSC cis rs9311676 0.656 rs56028017 chr3:58372508 C/T cg26110898 chr3:58419937 PDHB 0.41 6.69 0.34 9.67e-11 Systemic lupus erythematosus; LUSC cis rs11190604 1.000 rs3750630 chr10:102275780 A/G cg07080220 chr10:102295463 HIF1AN 0.67 9.41 0.46 8.22e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg00814883 chr7:100076585 TSC22D4 -0.75 -10.26 -0.49 1.18e-21 Platelet count; LUSC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg05425664 chr17:57184151 TRIM37 -0.56 -8.32 -0.41 2.21e-15 Intelligence (multi-trait analysis); LUSC cis rs13064411 0.696 rs2399479 chr3:113227050 G/A cg18753928 chr3:113234510 CCDC52 -0.54 -8.21 -0.41 4.85e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs1670533 1.000 rs13119276 chr4:1051574 T/C cg19318889 chr4:1322082 MAEA 0.43 5.66 0.3 3.22e-8 Recombination rate (females); LUSC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg08508325 chr11:3079039 CARS -0.53 -13.82 -0.6 1.15e-34 Longevity; LUSC cis rs11971779 0.715 rs11772771 chr7:139058803 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.03 0.36 1.16e-11 Diisocyanate-induced asthma; LUSC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg14298792 chr15:30685198 CHRFAM7A -0.46 -5.66 -0.3 3.32e-8 Huntington's disease progression; LUSC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg10523679 chr1:76189770 ACADM 0.93 20.17 0.74 9.82e-60 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6942756 0.876 rs28636722 chr7:129015151 C/T cg02491457 chr7:128862824 NA -0.41 -5.95 -0.31 6.64e-9 White matter hyperintensity burden; LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg16339924 chr4:17578868 LAP3 0.59 9.15 0.45 5.86e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg19418458 chr7:158789849 NA 0.63 10.61 0.5 7.41e-23 Facial morphology (factor 20); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg00476814 chr22:19974536 ARVCF 0.38 6.46 0.33 3.64e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg24562669 chr7:97807699 LMTK2 0.35 6.06 0.31 3.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs201673768 1 rs201673768 chr12:48699606 TGTTTTGTTTTG/T cg24011408 chr12:48396354 COL2A1 0.48 8.06 0.4 1.42e-14 Platelet count; LUSC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg23985595 chr17:80112537 CCDC57 -0.3 -5.7 -0.3 2.64e-8 Life satisfaction; LUSC cis rs6582630 0.576 rs11504369 chr12:38274566 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.38 -0.37 1.25e-12 Drug-induced liver injury (flucloxacillin); LUSC cis rs1670533 1.000 rs11725984 chr4:1087338 C/T cg16405210 chr4:1374714 KIAA1530 -0.48 -5.85 -0.3 1.2e-8 Recombination rate (females); LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg13685833 chr1:53393034 SCP2 -0.37 -5.67 -0.3 3.08e-8 Monocyte count; LUSC cis rs3760982 0.935 rs10422990 chr19:44295273 C/T cg11993925 chr19:44307056 LYPD5 0.28 6.06 0.31 3.68e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg17420585 chr12:42539391 GXYLT1 -0.39 -7.78 -0.39 9.23e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg06271696 chr7:157225062 NA -0.39 -7.66 -0.39 2.09e-13 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg18825119 chr6:163149453 PACRG;PARK2 -0.36 -6.48 -0.33 3.22e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg27494647 chr7:150038898 RARRES2 0.46 6.91 0.35 2.52e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg10729496 chr3:10149963 C3orf24 0.52 6.96 0.36 1.76e-11 Alzheimer's disease; LUSC cis rs28655083 0.550 rs598340 chr16:77102504 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.39 6.26 0.32 1.21e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs67478160 0.634 rs2295140 chr14:104216293 C/T cg08213375 chr14:104286397 PPP1R13B 0.45 8.61 0.43 2.83e-16 Schizophrenia; LUSC cis rs7923609 0.936 rs10822160 chr10:65112796 T/G cg01631684 chr10:65280961 REEP3 -0.41 -6.31 -0.33 8.98e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg00745463 chr17:30367425 LRRC37B -0.87 -10.22 -0.49 1.66e-21 Hip circumference adjusted for BMI; LUSC cis rs10193935 0.901 rs222486 chr2:42649664 C/T cg27598129 chr2:42591480 NA -0.59 -8.06 -0.4 1.38e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.754 rs12509621 chr4:120249660 T/C cg25214090 chr10:38739885 LOC399744 0.43 6.47 0.33 3.54e-10 Corneal astigmatism; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.69 0.43 1.66e-16 Prudent dietary pattern; LUSC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg15664640 chr17:80829946 TBCD -0.62 -8.34 -0.42 1.94e-15 Bone mineral accretion in asthma (oral corticosteroid dose interaction); LUSC cis rs1775715 0.677 rs2808074 chr10:32179184 A/C cg26784012 chr10:32216390 ARHGAP12 0.46 7.84 0.39 6.15e-14 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs56011263 0.687 rs4690293 chr4:706101 A/G cg12575136 chr18:32820987 ZNF397 0.53 9.47 0.46 5.11e-19 White blood cell count; LUSC cis rs250677 0.652 rs168751 chr5:148438264 C/T cg12140854 chr5:148520817 ABLIM3 -0.42 -6.17 -0.32 2.01e-9 Breast cancer; LUSC cis rs7605378 1.000 rs769954 chr2:200692159 C/G cg23649088 chr2:200775458 C2orf69 -0.52 -8.05 -0.4 1.5e-14 Osteoporosis; LUSC cis rs977987 0.931 rs11641430 chr16:75495276 T/C cg03315344 chr16:75512273 CHST6 0.52 9.8 0.47 4.44e-20 Dupuytren's disease; LUSC cis rs8058578 1.000 rs13338946 chr16:30700858 T/C cg02466173 chr16:30829666 NA -0.57 -10.48 -0.5 2.16e-22 Multiple myeloma; LUSC cis rs13089785 0.725 rs2222822 chr3:123604788 T/A cg19611163 chr3:123411211 MYLK 0.35 5.85 0.3 1.17e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.9 -0.55 1.77e-27 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg23630131 chr7:65973040 NA -0.21 -5.8 -0.3 1.55e-8 Aortic root size; LUSC cis rs6964587 0.869 rs7810391 chr7:91520227 G/A cg22709100 chr7:91322751 NA -0.39 -5.8 -0.3 1.56e-8 Breast cancer; LUSC cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg27446573 chr6:127587934 RNF146 0.83 11.94 0.55 1.26e-27 Breast cancer; LUSC cis rs28374715 0.681 rs28712264 chr15:41588797 T/C cg18705301 chr15:41695430 NDUFAF1 -1.01 -20.42 -0.75 9.81e-61 Ulcerative colitis; LUSC cis rs1891275 0.509 rs34190234 chr10:93443074 A/C cg07889827 chr10:93443413 NA -0.38 -8.35 -0.42 1.86e-15 Intelligence (multi-trait analysis); LUSC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg08493051 chr2:3487164 NA -0.52 -8.29 -0.41 2.75e-15 Neurofibrillary tangles; LUSC cis rs17125944 0.615 rs12587286 chr14:53304751 C/T cg00686598 chr14:53173677 PSMC6 0.92 7.65 0.39 2.15e-13 Alzheimer's disease (late onset); LUSC cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.5 -7.07 -0.36 8.9e-12 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs2197308 0.606 rs2218397 chr12:38278307 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.28 -0.41 2.98e-15 Morning vs. evening chronotype; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg09177884 chr7:1199841 ZFAND2A -0.58 -8.08 -0.4 1.16e-14 Longevity;Endometriosis; LUSC cis rs7937682 0.575 rs12808601 chr11:111776066 G/A cg09085632 chr11:111637200 PPP2R1B 0.94 13.31 0.59 1.05e-32 Primary sclerosing cholangitis; LUSC cis rs753274 0.650 rs72998945 chr19:14418441 C/A cg25450033 chr19:14444658 NA 0.34 5.84 0.3 1.25e-8 Tumor necrosis factor beta levels; LUSC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg21984481 chr17:79567631 NPLOC4 -0.72 -14.88 -0.63 9e-39 Eye color traits; LUSC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg25174290 chr11:3078921 CARS 0.59 9.47 0.46 5.12e-19 Longevity; LUSC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg21028142 chr17:79581711 NPLOC4 0.34 8.33 0.41 2.11e-15 Eye color traits; LUSC cis rs7954584 0.813 rs12827200 chr12:122451278 G/A cg22618164 chr12:122356400 WDR66 0.55 8.0 0.4 2.01e-14 Mean corpuscular volume; LUSC cis rs9325144 0.602 rs11169100 chr12:39077861 G/T cg26384229 chr12:38710491 ALG10B -0.61 -9.21 -0.45 3.72e-18 Morning vs. evening chronotype; LUSC trans rs67133203 0.904 rs12830073 chr12:51419381 G/A cg17484237 chr5:156536107 HAVCR2 0.44 5.97 0.31 6.1e-9 Urinary tract infection frequency; LUSC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg23205692 chr1:25664452 TMEM50A 0.39 5.83 0.3 1.33e-8 Plateletcrit;Mean corpuscular volume; LUSC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg20135002 chr11:47629003 NA -0.44 -7.08 -0.36 8.5e-12 Subjective well-being; LUSC cis rs425277 1.000 rs262672 chr1:2080813 G/T cg03732007 chr1:2071316 PRKCZ 0.48 7.65 0.39 2.18e-13 Height; LUSC cis rs77741769 1.000 rs77741769 chr12:121363835 C/T cg02419362 chr12:121203948 SPPL3 0.35 5.85 0.3 1.2e-8 Mean corpuscular volume; LUSC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg05110241 chr16:68378359 PRMT7 -0.56 -6.51 -0.34 2.7e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs7829975 0.742 rs7832968 chr8:8652889 G/A cg27411982 chr8:10470053 RP1L1 0.4 6.09 0.32 3.15e-9 Mood instability; LUSC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21659725 chr3:3221576 CRBN -0.89 -18.1 -0.7 1.6e-51 Intelligence (multi-trait analysis); LUSC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg05855489 chr10:104503620 C10orf26 0.6 9.57 0.46 2.47e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg06028605 chr16:24865363 SLC5A11 -0.68 -10.81 -0.51 1.45e-23 Intelligence (multi-trait analysis); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg14498460 chr14:104129107 KLC1 -0.39 -6.33 -0.33 8.1e-10 N-glycan levels; LUSC cis rs9807989 0.765 rs6704565 chr2:102967431 G/A cg03938978 chr2:103052716 IL18RAP 0.32 5.85 0.3 1.19e-8 Asthma; LUSC cis rs10949834 0.517 rs810536 chr7:73504233 G/A cg07137043 chr7:73588983 EIF4H 0.52 6.27 0.32 1.12e-9 Verbal memory performance (residualized delayed recall change); LUSC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg02772935 chr3:125709198 NA -0.48 -5.86 -0.31 1.12e-8 Blood pressure (smoking interaction); LUSC cis rs4964805 1.000 rs4964806 chr12:104192760 C/T cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC cis rs6494488 0.500 rs72741307 chr15:64700223 G/A cg08069370 chr15:64387884 SNX1 -0.65 -5.71 -0.3 2.54e-8 Coronary artery disease; LUSC trans rs853679 0.517 rs9393887 chr6:28059020 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.68e-9 Depression; LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.967 rs10746357 chr12:86341044 A/T cg02569458 chr12:86230093 RASSF9 0.42 6.67 0.34 1.09e-10 Major depressive disorder; LUSC cis rs1023500 0.573 rs133378 chr22:42467695 G/C cg05082376 chr22:42548792 NA -0.43 -6.43 -0.33 4.34e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg03676636 chr4:99064102 C4orf37 -0.34 -7.6 -0.38 3.09e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.25 0.52 4.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg04414720 chr1:150670196 GOLPH3L 0.53 8.26 0.41 3.52e-15 Melanoma; LUSC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg07636037 chr3:49044803 WDR6 0.8 11.62 0.54 1.91e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs977987 0.806 rs4887824 chr16:75441613 T/C cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.8e-17 Dupuytren's disease; LUSC trans rs7647973 0.626 rs4855846 chr3:49683526 G/A cg21659725 chr3:3221576 CRBN -0.68 -7.85 -0.39 5.77e-14 Menarche (age at onset); LUSC trans rs9329221 0.662 rs4240645 chr8:10254463 C/G cg06636001 chr8:8085503 FLJ10661 -0.55 -7.34 -0.37 1.69e-12 Neuroticism; LUSC cis rs8014204 1.000 rs4553560 chr14:75334199 T/C cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.3 -0.53 2.71e-25 Caffeine consumption; LUSC trans rs208520 0.770 rs2153941 chr6:66885521 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -15.19 -0.64 5.5e-40 Exhaled nitric oxide output; LUSC cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg02423579 chr7:2872169 GNA12 -0.42 -6.6 -0.34 1.61e-10 Height; LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg27170947 chr2:26402098 FAM59B 0.65 9.56 0.46 2.73e-19 Gut microbiome composition (summer); LUSC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg03351412 chr1:154909251 PMVK 0.55 8.85 0.44 5.3e-17 Prostate cancer; LUSC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg12311346 chr5:56204834 C5orf35 -0.84 -12.95 -0.58 2.23e-31 Initial pursuit acceleration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22317537 chr8:144099822 LY6E;LOC100133669 0.42 6.36 0.33 6.56e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg13319975 chr6:146136371 FBXO30 0.48 7.23 0.37 3.33e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg07677032 chr17:61819896 STRADA 0.55 9.2 0.45 4.08e-18 Prudent dietary pattern; LUSC cis rs9325144 0.555 rs7301258 chr12:38706942 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.49 0.33 3.18e-10 Morning vs. evening chronotype; LUSC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg06238570 chr21:40685208 BRWD1 0.45 6.92 0.35 2.29e-11 Cognitive function; LUSC cis rs4443100 0.958 rs9608066 chr22:23387172 A/G cg21100191 chr22:23484243 RTDR1 0.47 5.69 0.3 2.8e-8 Serum parathyroid hormone levels; LUSC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg18099408 chr3:52552593 STAB1 -0.41 -7.24 -0.37 3.02e-12 Bipolar disorder; LUSC cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC cis rs7119038 0.818 rs10892288 chr11:118644694 A/G cg19308663 chr11:118741387 NA 0.37 6.33 0.33 7.82e-10 Sjögren's syndrome; LUSC cis rs80282103 0.764 rs10047382 chr10:1102868 T/C cg18964960 chr10:1102726 WDR37 0.73 6.71 0.34 8.45e-11 Glomerular filtration rate (creatinine); LUSC cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs9549367 0.737 rs71446680 chr13:113894846 C/T cg18105134 chr13:113819100 PROZ -0.7 -10.1 -0.48 4.04e-21 Platelet distribution width; LUSC cis rs11997175 0.600 rs4739590 chr8:33802686 A/G ch.8.33884649F chr8:33765107 NA 0.4 6.31 0.33 8.68e-10 Body mass index; LUSC cis rs66486766 1 rs66486766 chr15:84806060 G/A cg17173187 chr15:85201210 NMB 0.37 6.44 0.33 4.09e-10 Bipolar disorder lithium response (categorical) or schizophrenia; LUSC cis rs11229555 0.609 rs7128459 chr11:58179291 C/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7107174 1.000 rs2450123 chr11:77952771 T/C cg02023728 chr11:77925099 USP35 0.52 7.27 0.37 2.52e-12 Testicular germ cell tumor; LUSC cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg12698349 chr2:225449008 CUL3 0.67 8.57 0.42 3.82e-16 IgE levels in asthmatics (D.p. specific); LUSC cis rs7103648 0.864 rs10769264 chr11:47423340 C/T cg20307385 chr11:47447363 PSMC3 0.99 19.43 0.73 8.48e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs7267979 0.932 rs6138600 chr20:25521346 A/T cg08601574 chr20:25228251 PYGB 0.39 5.96 0.31 6.48e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs372883 0.597 rs2018956 chr21:30736622 C/A cg08807101 chr21:30365312 RNF160 0.5 7.44 0.38 8.77e-13 Pancreatic cancer; LUSC cis rs7474896 0.537 rs1208587 chr10:38207759 A/G cg25427524 chr10:38739819 LOC399744 0.42 5.67 0.3 3.04e-8 Obesity (extreme); LUSC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg11764359 chr7:65958608 NA -0.7 -10.97 -0.51 4.1e-24 Aortic root size; LUSC cis rs929354 0.772 rs1182364 chr7:157017912 T/C cg05182265 chr7:156933206 UBE3C 0.58 9.39 0.46 9.77e-19 Body mass index; LUSC cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg01528321 chr10:82214614 TSPAN14 0.62 9.02 0.44 1.54e-17 Post bronchodilator FEV1; LUSC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg09359103 chr1:154839909 KCNN3 -0.58 -12.02 -0.55 6.79e-28 Prostate cancer; LUSC cis rs8072100 0.967 rs11079784 chr17:45702280 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.79 0.3 1.64e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg05555928 chr11:63887634 MACROD1 0.33 5.77 0.3 1.79e-8 Platelet count; LUSC cis rs11209185 0.545 rs12030775 chr1:68421189 A/T cg22082780 chr1:68452167 NA 0.4 6.81 0.35 4.47e-11 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.9 -0.35 2.57e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg22782873 chr19:19639568 YJEFN3 -0.47 -5.82 -0.3 1.39e-8 Bipolar disorder; LUSC cis rs6500395 1.000 rs7187513 chr16:48591638 T/C cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6961069 0.585 rs62461689 chr7:80245769 G/C cg04458919 chr7:80252533 CD36 -0.39 -6.88 -0.35 2.9e-11 Platelet count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26140352 chr6:83777368 DOPEY1 0.75 6.51 0.34 2.75e-10 Cognitive performance; LUSC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg16624210 chr5:671434 TPPP 0.5 6.54 0.34 2.35e-10 Obesity-related traits; LUSC cis rs3916 0.641 rs2393749 chr12:121131891 C/T cg27246729 chr12:121163418 ACADS 0.39 6.13 0.32 2.43e-9 Urinary metabolites (H-NMR features); LUSC cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg11984989 chr7:158649758 WDR60 -0.99 -17.05 -0.68 2.43e-47 Height; LUSC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.59 8.78 0.43 8.59e-17 Alzheimer's disease; LUSC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg00129232 chr17:37814104 STARD3 -0.41 -5.85 -0.3 1.18e-8 Asthma; LUSC cis rs561341 0.700 rs8079471 chr17:30218317 A/G cg00745463 chr17:30367425 LRRC37B -0.48 -6.33 -0.33 8.01e-10 Hip circumference adjusted for BMI; LUSC cis rs8113142 0.614 rs73028023 chr19:29134072 C/T cg04546413 chr19:29218101 NA 0.43 5.91 0.31 8.41e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg11584989 chr19:19387371 SF4 -0.62 -7.26 -0.37 2.72e-12 Bipolar disorder; LUSC cis rs6961069 0.742 rs3211849 chr7:80283323 A/G cg04458919 chr7:80252533 CD36 -0.34 -6.08 -0.32 3.34e-9 Platelet count; LUSC cis rs9486719 0.843 rs3860230 chr6:97036560 T/A cg06623918 chr6:96969491 KIAA0776 -0.83 -12.1 -0.55 3.35e-28 Migraine;Coronary artery disease; LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.47 -7.07 -0.36 8.91e-12 Alzheimer's disease (late onset); LUSC cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.32 0.53 2.22e-25 Colorectal cancer; LUSC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg01879757 chr17:41196368 BRCA1 -0.46 -6.9 -0.35 2.59e-11 Menopause (age at onset); LUSC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs56399783 0.614 rs116929101 chr7:2760325 G/A cg19731401 chr7:2775893 GNA12 0.71 8.3 0.41 2.59e-15 Childhood ear infection; LUSC cis rs9715521 0.677 rs17493148 chr4:59861895 T/C cg11281224 chr4:60001000 NA -0.51 -6.97 -0.36 1.73e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9905704 0.633 rs917016 chr17:56454156 C/T cg12560992 chr17:57184187 TRIM37 -0.48 -5.66 -0.3 3.18e-8 Testicular germ cell tumor; LUSC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.63 -0.39 2.43e-13 Developmental language disorder (linguistic errors); LUSC cis rs7089973 0.604 rs2420067 chr10:116590348 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.21 0.45 3.72e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4363385 0.747 rs9659623 chr1:152965158 C/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.43 -0.38 9.16e-13 Inflammatory skin disease; LUSC cis rs56145559 1 rs56145559 chr2:73623439 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.65 -0.34 1.16e-10 Schizophrenia; LUSC cis rs765787 0.530 rs2554457 chr15:45520926 G/A cg24006582 chr15:45444508 DUOX1 -0.61 -8.96 -0.44 2.4e-17 Uric acid levels; LUSC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg04369109 chr6:150039330 LATS1 -0.54 -7.78 -0.39 9.26e-14 Lung cancer; LUSC cis rs2898681 0.519 rs73814886 chr4:53733251 C/T cg21521518 chr4:53727714 RASL11B 0.44 5.85 0.3 1.19e-8 Optic nerve measurement (cup area); LUSC trans rs4332037 0.906 rs6461009 chr7:1952139 T/C cg25206134 chr2:45395956 NA -0.55 -6.55 -0.34 2.13e-10 Bipolar disorder; LUSC cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22496380 chr5:211416 CCDC127 -0.84 -9.09 -0.45 9.11e-18 Breast cancer; LUSC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg17376030 chr22:41985996 PMM1 -0.47 -5.76 -0.3 1.89e-8 Cannabis dependence symptom count; LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg02951883 chr7:2050386 MAD1L1 -0.35 -5.94 -0.31 7.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg24399712 chr22:39784796 NA -0.61 -10.86 -0.51 1.01e-23 Intelligence (multi-trait analysis); LUSC cis rs7651511 0.651 rs7632308 chr3:141196260 T/C cg00789793 chr3:141329863 RASA2 0.38 5.76 0.3 1.88e-8 Mean corpuscular hemoglobin; LUSC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg15369054 chr17:80825471 TBCD 0.68 11.24 0.52 4.42e-25 Breast cancer; LUSC cis rs7264396 0.836 rs6058282 chr20:34212590 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.54 -0.46 3.03e-19 Total cholesterol levels; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg18240062 chr17:79603768 NPLOC4 0.6 10.32 0.49 7.26e-22 Eye color traits; LUSC cis rs17253792 0.822 rs74051609 chr14:56171132 G/A cg01858014 chr14:56050164 KTN1 -0.7 -6.2 -0.32 1.63e-9 Putamen volume; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07229938 chr10:124907600 HMX2 -0.37 -6.07 -0.32 3.39e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg12219531 chr12:120966889 COQ5 0.61 8.11 0.41 9.99e-15 High light scatter reticulocyte count; LUSC cis rs7911264 0.739 rs7071905 chr10:94386122 T/G cg25093409 chr10:94429542 NA 0.36 6.21 0.32 1.59e-9 Inflammatory bowel disease; LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs3925075 1.000 rs55742763 chr16:31340368 G/A cg02846316 chr16:31340340 ITGAM 0.36 6.63 0.34 1.33e-10 IgA nephropathy; LUSC cis rs2652834 0.851 rs2652795 chr15:63409265 T/C cg05507819 chr15:63340323 TPM1 0.46 5.94 0.31 7.3e-9 HDL cholesterol; LUSC cis rs11764590 0.694 rs2056477 chr7:2079744 G/C cg02951883 chr7:2050386 MAD1L1 0.45 6.35 0.33 6.95e-10 Neuroticism; LUSC trans rs941408 1.000 rs1640273 chr19:2803227 C/T cg19676328 chr12:49525230 TUBA1B -0.54 -8.69 -0.43 1.62e-16 Total cholesterol levels; LUSC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg13531842 chr10:38383804 ZNF37A -0.48 -7.47 -0.38 7.1e-13 Extrinsic epigenetic age acceleration; LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg26314531 chr2:26401878 FAM59B 0.75 10.1 0.48 4.27e-21 Gut microbiome composition (summer); LUSC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg16339924 chr4:17578868 LAP3 -0.58 -8.69 -0.43 1.63e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs17807624 0.964 rs13249843 chr8:11459018 G/T cg06636001 chr8:8085503 FLJ10661 0.5 7.16 0.36 5.12e-12 Systemic lupus erythematosus; LUSC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg04362960 chr10:104952993 NT5C2 0.59 9.33 0.45 1.51e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs782590 1.000 rs782594 chr2:55844445 T/C cg18811423 chr2:55921094 PNPT1 0.83 14.48 0.62 3.23e-37 Metabolic syndrome; LUSC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg22920501 chr2:26401640 FAM59B -0.73 -10.24 -0.49 1.38e-21 Gut microbiome composition (summer); LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg11843238 chr5:131593191 PDLIM4 0.36 6.67 0.34 1.05e-10 Blood metabolite levels; LUSC cis rs67460515 0.892 rs10513564 chr3:161059762 A/G cg03342759 chr3:160939853 NMD3 -0.55 -8.11 -0.41 9.67e-15 Parkinson's disease; LUSC cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg09184832 chr6:79620586 NA -0.44 -7.0 -0.36 1.39e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs877282 0.533 rs10904565 chr10:819991 G/T cg22713356 chr15:30763199 NA 0.72 9.41 0.46 8.34e-19 Uric acid levels; LUSC cis rs6840360 0.615 rs6535822 chr4:152679722 A/G cg22705602 chr4:152727874 NA -0.35 -7.76 -0.39 1.02e-13 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg15744005 chr10:104629667 AS3MT -0.37 -7.54 -0.38 4.38e-13 Arsenic metabolism; LUSC cis rs3740713 1.000 rs1848048 chr11:18468996 T/C cg07915343 chr11:18477680 LDHAL6A -0.54 -6.74 -0.35 6.85e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg15105969 chr2:36825350 FEZ2 -0.43 -5.81 -0.3 1.45e-8 Height; LUSC trans rs11700980 1.000 rs35893000 chr21:30123965 C/T cg05609335 chr17:75789393 NA 0.41 6.32 0.33 8.58e-10 QRS complex (12-leadsum); LUSC cis rs9902453 1.000 rs28664971 chr17:28437410 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.45 0.5 2.73e-22 Coffee consumption (cups per day); LUSC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC cis rs859767 0.779 rs6430528 chr2:135395348 A/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.22 -0.32 1.48e-9 Neuroticism; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg23758822 chr17:41437982 NA 1.03 19.51 0.73 4.23e-57 Menopause (age at onset); LUSC cis rs7246657 0.943 rs10403613 chr19:37844306 C/T cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18301423 chr5:131593218 PDLIM4 0.47 7.38 0.37 1.26e-12 Acylcarnitine levels; LUSC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg09783858 chr11:65769428 EIF1AD;BANF1 0.44 6.27 0.32 1.09e-9 Breast cancer; LUSC cis rs9549367 0.789 rs12869947 chr13:113896156 A/G cg00898013 chr13:113819073 PROZ -0.55 -8.04 -0.4 1.61e-14 Platelet distribution width; LUSC trans rs970548 0.738 rs61854124 chr10:46077158 T/C cg20477318 chr10:51623047 TIMM23 0.58 5.96 0.31 6.38e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs72781680 1.000 rs72781631 chr2:24195064 G/A cg08917208 chr2:24149416 ATAD2B 0.88 10.02 0.48 7.97e-21 Lymphocyte counts; LUSC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg13012494 chr21:47604986 C21orf56 0.4 5.82 0.3 1.35e-8 Testicular germ cell tumor; LUSC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg09359103 chr1:154839909 KCNN3 -0.58 -12.02 -0.55 6.79e-28 Prostate cancer; LUSC trans rs7824557 0.564 rs2736301 chr8:11236413 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.83 -0.39 6.41e-14 Retinal vascular caliber; LUSC trans rs6951245 0.744 rs10265758 chr7:1172518 C/T cg13565492 chr6:43139072 SRF -0.6 -7.07 -0.36 9.1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17818399 0.547 rs7607308 chr2:46759104 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.52 -6.84 -0.35 3.82e-11 Height; LUSC cis rs778371 0.697 rs2344613 chr2:233603065 C/G cg08000102 chr2:233561755 GIGYF2 0.79 12.38 0.56 3.07e-29 Schizophrenia; LUSC trans rs61931739 0.500 rs35030191 chr12:34548865 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC trans rs6951245 0.554 rs35126802 chr7:1134842 C/T cg13565492 chr6:43139072 SRF -0.73 -10.83 -0.51 1.25e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9300255 0.722 rs28458312 chr12:123863265 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 5.74 0.3 2.12e-8 Neutrophil percentage of white cells; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg03354898 chr7:1950403 MAD1L1 -0.43 -8.86 -0.44 4.7e-17 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg24675658 chr1:53192096 ZYG11B -0.59 -9.32 -0.45 1.67e-18 Monocyte count; LUSC cis rs2288073 0.965 rs10173949 chr2:24410256 A/C cg06627628 chr2:24431161 ITSN2 -0.74 -10.35 -0.49 5.96e-22 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs6489882 0.902 rs4767037 chr12:113372804 A/C cg20102336 chr12:113376681 OAS3 -0.42 -6.03 -0.31 4.29e-9 Chronic lymphocytic leukemia; LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg12041069 chr6:45341222 RUNX2;SUPT3H -0.4 -6.36 -0.33 6.6e-10 Breast cancer; LUSC cis rs35000415 0.688 rs13232316 chr7:128715299 A/T cg19972273 chr7:128594194 NA 0.54 5.83 0.3 1.34e-8 Systemic lupus erythematosus; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg04352962 chr1:209979756 IRF6 0.63 10.96 0.51 4.42e-24 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg20243544 chr17:37824526 PNMT 0.5 7.2 0.37 4.09e-12 Asthma; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg06873352 chr17:61820015 STRADA 0.71 12.72 0.57 1.68e-30 Prudent dietary pattern; LUSC cis rs10465746 0.967 rs12118434 chr1:84328629 C/T cg10977910 chr1:84465055 TTLL7 0.43 6.27 0.32 1.11e-9 Obesity-related traits; LUSC cis rs67311347 0.713 rs9861194 chr3:40309225 C/T cg17264618 chr3:40429014 ENTPD3 0.3 6.6 0.34 1.66e-10 Renal cell carcinoma; LUSC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg24829409 chr8:58192753 C8orf71 -0.56 -5.94 -0.31 7.02e-9 Developmental language disorder (linguistic errors); LUSC cis rs1568889 1.000 rs1464897 chr11:28034844 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.44 0.46 6.65e-19 Bipolar disorder; LUSC cis rs968567 0.705 rs174575 chr11:61602003 C/G cg21709803 chr11:61594965 FADS2 -0.36 -5.78 -0.3 1.67e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs1348850 0.598 rs1405717 chr2:178500101 G/T cg22681709 chr2:178499509 PDE11A -0.6 -12.03 -0.55 6.02e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7639513 0.590 rs3729931 chr3:12626516 A/G cg23032965 chr3:12705835 RAF1 -0.63 -10.31 -0.49 8.04e-22 Itch intensity from mosquito bite; LUSC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12794691 chr3:111805077 C3orf52 0.75 5.96 0.31 6.41e-9 Cognitive performance; LUSC trans rs7824557 0.767 rs6985460 chr8:11171087 A/C cg06636001 chr8:8085503 FLJ10661 0.53 7.93 0.4 3.44e-14 Retinal vascular caliber; LUSC cis rs12791968 0.765 rs12226848 chr11:45009204 C/T cg11846598 chr11:44996168 LOC221122 -0.55 -7.7 -0.39 1.59e-13 Inhibitory control; LUSC cis rs4664304 0.802 rs3792175 chr2:160862804 T/A cg23995753 chr2:160760732 LY75 -0.32 -5.95 -0.31 6.73e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg02269571 chr22:50332266 NA -0.57 -8.59 -0.43 3.41e-16 Schizophrenia; LUSC cis rs9311676 0.656 rs62258093 chr3:58371745 T/C cg26110898 chr3:58419937 PDHB 0.41 6.69 0.34 9.67e-11 Systemic lupus erythematosus; LUSC cis rs34638657 0.732 rs12102917 chr16:82196808 G/A cg09439754 chr16:82129088 HSD17B2 -0.4 -6.68 -0.34 1.02e-10 Lung adenocarcinoma; LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg11766577 chr21:47581405 C21orf56 -0.56 -8.78 -0.43 8.84e-17 Testicular germ cell tumor; LUSC cis rs7312933 0.669 rs7974476 chr12:42542484 C/A cg17420585 chr12:42539391 GXYLT1 -0.36 -6.8 -0.35 4.82e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg03676636 chr4:99064102 C4orf37 0.33 7.11 0.36 6.98e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2742417 1.000 rs2673036 chr3:45752471 C/T cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs3771570 0.901 rs4675944 chr2:242430170 C/T cg21155796 chr2:242212141 HDLBP 0.61 7.09 0.36 7.88e-12 Prostate cancer; LUSC cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.83 -0.43 6.12e-17 Monocyte percentage of white cells; LUSC cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg19875535 chr5:140030758 IK -0.54 -8.88 -0.44 4.13e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs425277 1.000 rs12401379 chr1:2058580 G/C cg24578937 chr1:2090814 PRKCZ 0.57 12.95 0.58 2.37e-31 Height; LUSC cis rs1580019 0.885 rs4460270 chr7:32496450 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.66 0.54 1.35e-26 Cognitive ability; LUSC cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg04518342 chr5:131593106 PDLIM4 0.45 8.21 0.41 5e-15 Breast cancer; LUSC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 9.76 0.47 5.8e-20 Eosinophil percentage of white cells; LUSC cis rs7833986 1.000 rs61690651 chr8:57096661 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.58 8.87 0.44 4.64e-17 Height; LUSC cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs17255340 0.577 rs13197603 chr6:84075113 C/T cg08257003 chr6:84140564 ME1 0.32 7.35 0.37 1.49e-12 Platelet-derived growth factor BB levels; LUSC cis rs4474465 0.915 rs12274873 chr11:78183015 C/G cg27205649 chr11:78285834 NARS2 -0.48 -5.68 -0.3 2.93e-8 Alzheimer's disease (survival time); LUSC cis rs10782582 0.569 rs4549990 chr1:76125075 A/G cg10523679 chr1:76189770 ACADM -0.49 -7.16 -0.36 5.33e-12 Daytime sleep phenotypes; LUSC cis rs12701220 0.541 rs12535516 chr7:1114440 C/G cg26769984 chr7:1090371 C7orf50 0.57 7.21 0.37 3.84e-12 Bronchopulmonary dysplasia; LUSC cis rs4805272 0.512 rs4805278 chr19:29336664 C/T cg03161606 chr19:29218774 NA 0.51 6.0 0.31 5.03e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs1298908 0.639 rs2994388 chr10:82034262 A/G cg01528321 chr10:82214614 TSPAN14 -0.57 -8.21 -0.41 4.74e-15 Diabetic kidney disease; LUSC cis rs17014483 0.749 rs2924935 chr4:89640567 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.65 5.75 0.3 2.07e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.12e-9 Menopause (age at onset); LUSC cis rs60843830 1.000 rs114976176 chr2:264621 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.61 9.25 0.45 2.7e-18 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg20406979 chr6:167373233 NA 0.25 5.96 0.31 6.39e-9 Crohn's disease; LUSC cis rs926392 0.896 rs1569538 chr20:37685216 A/G cg27552599 chr20:37590471 DHX35 -0.33 -5.84 -0.3 1.23e-8 Dialysis-related mortality; LUSC cis rs11642862 1.000 rs112234000 chr16:30778808 G/A cg02466173 chr16:30829666 NA -0.71 -7.59 -0.38 3.31e-13 Tonsillectomy; LUSC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg11845111 chr2:191398756 TMEM194B 0.56 9.37 0.46 1.16e-18 Pulse pressure; LUSC cis rs983392 0.559 rs1426249 chr11:60002261 C/A cg20284999 chr11:59952153 MS4A6A -0.36 -5.97 -0.31 6e-9 Alzheimer's disease (late onset); LUSC trans rs6445525 0.967 rs6792662 chr3:65996707 G/C cg12639933 chr12:57626296 SHMT2 0.34 6.18 0.32 1.85e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10761482 0.500 rs7080540 chr10:62298586 A/T cg18175470 chr10:62150864 ANK3 -0.5 -7.23 -0.37 3.25e-12 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20956373 chr1:22109557 USP48 -0.43 -6.08 -0.32 3.34e-9 Electrocardiographic conduction measures; LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg05165339 chr4:1420672 NA 0.29 6.5 0.33 2.98e-10 Longevity; LUSC cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg17261708 chr5:176794207 RGS14 0.34 5.97 0.31 5.95e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs453301 0.624 rs2915251 chr8:8867411 G/C cg15556689 chr8:8085844 FLJ10661 0.68 10.76 0.51 2.23e-23 Joint mobility (Beighton score); LUSC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg05855489 chr10:104503620 C10orf26 0.58 9.35 0.46 1.33e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17739794 0.517 rs6559193 chr8:775451 C/T cg07178994 chr8:816998 NA -0.39 -5.84 -0.3 1.25e-8 Clozapine-induced cytotoxicity; LUSC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg06028605 chr16:24865363 SLC5A11 -0.69 -10.95 -0.51 4.66e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9318086 0.935 rs2025701 chr13:24440581 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.4 6.09 0.32 3.05e-9 Myopia (pathological); LUSC cis rs3824867 0.959 rs4237544 chr11:47454271 G/T cg20307385 chr11:47447363 PSMC3 -0.63 -9.29 -0.45 2e-18 Mean corpuscular hemoglobin; LUSC cis rs7223966 1.000 rs112143304 chr17:61822401 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.93 0.35 2.16e-11 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs4689592 0.546 rs907523 chr4:7052777 A/G cg07817883 chr1:32538562 TMEM39B -0.57 -6.73 -0.35 7.39e-11 Monocyte percentage of white cells; LUSC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9788682 0.747 rs11072766 chr15:78771546 C/T cg18825076 chr15:78729989 IREB2 0.44 6.13 0.32 2.46e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs877282 0.891 rs10904557 chr10:797490 C/T cg13042288 chr15:90349979 ANPEP 0.48 7.12 0.36 6.61e-12 Uric acid levels; LUSC cis rs6547741 0.935 rs6749426 chr2:27847606 T/C cg27432699 chr2:27873401 GPN1 0.83 15.87 0.66 1.14e-42 Oral cavity cancer; LUSC cis rs9807989 0.811 rs11689730 chr2:102969984 C/A cg09003973 chr2:102972529 NA 0.44 6.04 0.31 4.15e-9 Asthma; LUSC cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg06002616 chr8:101225028 SPAG1 0.47 8.1 0.41 1.04e-14 Atrioventricular conduction; LUSC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg21782813 chr7:2030301 MAD1L1 0.57 10.02 0.48 7.5e-21 Bipolar disorder and schizophrenia; LUSC trans rs7495211 0.529 rs11247364 chr15:98623984 A/T cg08901157 chr15:56033728 PRTG 0.34 5.98 0.31 5.86e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs7181230 0.961 rs7183977 chr15:40377092 C/T cg22705835 chr10:65332833 REEP3 0.4 6.86 0.35 3.27e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg00484396 chr16:3507460 NAT15 -0.89 -10.55 -0.5 1.23e-22 Tuberculosis; LUSC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8014204 0.762 rs12891131 chr14:75240090 A/G cg06637938 chr14:75390232 RPS6KL1 0.51 8.01 0.4 1.95e-14 Caffeine consumption; LUSC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg02891314 chr5:179741120 GFPT2 -0.65 -10.62 -0.5 7.07e-23 Height; LUSC cis rs7508679 1.000 rs4804411 chr19:7222377 G/C cg09779027 chr19:7224513 INSR 0.43 9.37 0.46 1.09e-18 Hypothyroidism; LUSC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -7.38 -0.37 1.29e-12 Axial length; LUSC cis rs1950626 0.750 rs12895798 chr14:101442793 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.77 0.39 9.82e-14 Pelvic organ prolapse (moderate/severe); LUSC cis rs62103177 0.564 rs3930042 chr18:77723843 G/A cg20368463 chr18:77673604 PQLC1 0.73 7.51 0.38 5.47e-13 Opioid sensitivity; LUSC cis rs9788682 0.894 rs4461039 chr15:78817447 A/T cg18825076 chr15:78729989 IREB2 -0.46 -6.26 -0.32 1.2e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.48 0.69 4.89e-49 Chronic sinus infection; LUSC cis rs7954584 0.505 rs11043278 chr12:122412145 C/T cg01765077 chr12:122356316 WDR66 0.52 7.27 0.37 2.58e-12 Mean corpuscular volume; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg02353165 chr6:42928485 GNMT 0.7 12.12 0.55 2.81e-28 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC cis rs4654899 0.758 rs4457549 chr1:21487231 A/G cg01072550 chr1:21505969 NA 0.53 8.07 0.4 1.28e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg04978709 chr7:75101039 POM121C 0.47 6.96 0.36 1.77e-11 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg03188948 chr7:1209495 NA 0.47 6.21 0.32 1.59e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg01237263 chr17:21179546 NA 0.42 6.47 0.33 3.5e-10 N-glycan levels; LUSC cis rs6076065 0.644 rs1056394 chr20:23337422 G/A cg11657817 chr20:23433608 CST11 0.44 8.24 0.41 3.88e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg03644281 chr6:41068752 NFYA;LOC221442 0.45 6.74 0.35 6.97e-11 Alzheimer's disease (late onset); LUSC cis rs1387259 0.758 rs2634670 chr12:48771877 G/A cg04545296 chr12:48745243 ZNF641 0.3 5.74 0.3 2.17e-8 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs1044826 1.000 rs964227 chr3:139156093 C/A cg00490450 chr3:139108681 COPB2 0.53 6.95 0.36 1.94e-11 Obesity-related traits; LUSC cis rs77372450 0.636 rs10052322 chr5:157014420 C/A cg25387487 chr5:157003181 ADAM19 -0.5 -5.83 -0.3 1.28e-8 Bipolar disorder (body mass index interaction); LUSC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg09835421 chr16:68378352 PRMT7 -0.54 -6.15 -0.32 2.18e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg25072359 chr17:41440525 NA 0.64 9.15 0.45 5.64e-18 Menopause (age at onset); LUSC cis rs9549367 0.789 rs9549705 chr13:113888425 T/C cg18105134 chr13:113819100 PROZ -0.7 -9.96 -0.48 1.22e-20 Platelet distribution width; LUSC cis rs9296092 0.500 rs9461885 chr6:33521069 G/T cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.2 0.64 4.94e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs12946454 0.621 rs11651809 chr17:43255681 C/G cg10701640 chr17:43249399 NA 0.52 12.37 0.56 3.42e-29 Systolic blood pressure; LUSC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg11764359 chr7:65958608 NA 0.71 11.06 0.52 1.87e-24 Aortic root size; LUSC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.42 -7.01 -0.36 1.3e-11 Hip circumference adjusted for BMI; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg15117754 chr3:10150083 C3orf24 0.44 5.66 0.3 3.32e-8 Alzheimer's disease; LUSC cis rs950027 0.620 rs1719245 chr15:45623782 T/C cg21132104 chr15:45694354 SPATA5L1 0.41 5.94 0.31 7.1e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg00343986 chr7:65444356 GUSB 0.46 6.94 0.35 2.09e-11 Aortic root size; LUSC cis rs6570726 0.902 rs9390326 chr6:145791222 A/G cg05347473 chr6:146136440 FBXO30 -0.38 -6.3 -0.33 9.35e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg17143192 chr8:8559678 CLDN23 0.56 8.14 0.41 7.92e-15 Obesity-related traits; LUSC cis rs41307935 0.822 rs71636786 chr1:27177925 T/A cg25841309 chr1:27248983 NUDC -0.65 -5.81 -0.3 1.42e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg15704280 chr7:45808275 SEPT13 -0.46 -6.29 -0.33 1e-9 HDL cholesterol; LUSC cis rs1185460 0.967 rs1307145 chr11:118950217 C/G cg23280166 chr11:118938394 VPS11 0.47 7.27 0.37 2.55e-12 Coronary artery disease; LUSC trans rs9929218 0.508 rs1559366 chr16:68799611 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.96 19.57 0.73 2.38e-57 Colorectal cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16925090 chr11:101785516 KIAA1377;ANGPTL5 0.49 7.21 0.37 3.83e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2486288 0.656 rs7167146 chr15:45571386 A/G cg09092052 chr15:45571596 NA -0.46 -6.28 -0.33 1.03e-9 Glomerular filtration rate; LUSC cis rs2798269 0.668 rs1200055 chr13:22086127 A/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.02 -0.31 4.56e-9 PR segment; LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.83 -0.3 1.33e-8 Platelet count; LUSC cis rs9560113 1.000 rs9560103 chr13:112174253 G/A cg14154082 chr13:112174009 NA 0.38 7.95 0.4 2.97e-14 Menarche (age at onset); LUSC cis rs556990 0.570 rs5960 chr13:113801737 C/T cg18105134 chr13:113819100 PROZ 0.57 6.97 0.36 1.75e-11 Blood protein levels; LUSC cis rs9788721 0.967 rs55853698 chr15:78857939 T/G cg06917634 chr15:78832804 PSMA4 -0.48 -6.37 -0.33 6.11e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs992157 0.710 rs12694432 chr2:219082330 A/G cg00012203 chr2:219082015 ARPC2 0.89 17.23 0.69 4.71e-48 Colorectal cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05736393 chr2:74775957 LOXL3 0.45 6.87 0.35 3.19e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19433769 chr4:2420260 ZFYVE28 -0.39 -5.99 -0.31 5.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg20573242 chr4:122745356 CCNA2 0.44 6.76 0.35 6.05e-11 Type 2 diabetes; LUSC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.69 -0.3 2.85e-8 Vitiligo; LUSC trans rs6089829 0.962 rs6011544 chr20:61658782 T/C cg23505145 chr19:12996616 KLF1 0.64 10.29 0.49 9.57e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg16102102 chr5:83017553 HAPLN1 -0.91 -14.09 -0.61 1.06e-35 Prostate cancer; LUSC trans rs2786098 0.656 rs12116519 chr1:197565337 C/T cg16005942 chr6:160526640 IGF2R 0.5 6.02 0.31 4.61e-9 Asthma; LUSC cis rs4319547 0.656 rs10161534 chr12:122873864 T/C cg23029597 chr12:123009494 RSRC2 -0.68 -8.8 -0.43 7.39e-17 Body mass index; LUSC cis rs7582180 0.629 rs34745556 chr2:100942506 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.89e-8 Intelligence (multi-trait analysis); LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg01577475 chr2:114033581 PAX8;LOC440839 -0.3 -7.5 -0.38 5.75e-13 Lymphocyte counts; LUSC cis rs79149102 0.737 rs113915655 chr15:75219722 T/C cg09165964 chr15:75287851 SCAMP5 -0.9 -6.76 -0.35 6.21e-11 Lung cancer; LUSC cis rs55728055 0.661 rs62237772 chr22:31964975 A/C cg01338084 chr22:32026380 PISD 0.93 6.77 0.35 5.67e-11 Age-related hearing impairment; LUSC trans rs2786098 0.656 rs12125739 chr1:197529577 T/G cg16005942 chr6:160526640 IGF2R 0.51 6.08 0.32 3.31e-9 Asthma; LUSC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg05738196 chr6:26577821 NA 0.53 8.41 0.42 1.25e-15 Schizophrenia; LUSC cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg09184832 chr6:79620586 NA -0.45 -7.35 -0.37 1.57e-12 Intelligence (multi-trait analysis); LUSC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg13535736 chr9:111863775 C9orf5 -0.43 -7.1 -0.36 7.64e-12 Menarche (age at onset); LUSC cis rs12493885 0.818 rs73160504 chr3:153773384 C/T cg17054900 chr3:154042577 DHX36 -0.74 -7.55 -0.38 4.06e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7945718 0.967 rs10831904 chr11:12760937 A/G cg25843174 chr11:12811716 TEAD1 0.32 7.06 0.36 9.72e-12 Educational attainment (years of education); LUSC trans rs7824557 0.564 rs7834572 chr8:11236685 C/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.5 -0.34 2.9e-10 Retinal vascular caliber; LUSC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.39 0.37 1.19e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs921968 0.565 rs1541777 chr2:219587291 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.3 -0.49 8.75e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs61931739 0.500 rs11053185 chr12:34428857 A/G cg06521331 chr12:34319734 NA -0.41 -6.76 -0.35 6.27e-11 Morning vs. evening chronotype; LUSC cis rs806795 0.605 rs809871 chr6:26256526 C/G cg00631329 chr6:26305371 NA 0.43 7.7 0.39 1.52e-13 Mosquito bite size; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg16132339 chr22:24313637 DDTL;DDT 0.4 6.35 0.33 6.96e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9443645 0.527 rs12194642 chr6:79538791 G/A cg05283184 chr6:79620031 NA -0.46 -8.4 -0.42 1.34e-15 Intelligence (multi-trait analysis); LUSC cis rs4423214 1.000 rs1044482 chr11:71155171 C/T cg05163923 chr11:71159392 DHCR7 0.7 10.85 0.51 1.05e-23 Vitamin D levels; LUSC trans rs9291683 0.632 rs7679916 chr4:10042160 C/T cg26043149 chr18:55253948 FECH 0.49 7.24 0.37 3.02e-12 Bone mineral density; LUSC cis rs11209002 0.614 rs7552205 chr1:67551741 C/A cg02640540 chr1:67518911 SLC35D1 0.64 9.0 0.44 1.78e-17 Crohn's disease; LUSC trans rs853679 0.517 rs9380055 chr6:28081629 A/G cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg13047869 chr3:10149882 C3orf24 0.63 8.73 0.43 1.21e-16 Alzheimer's disease; LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs6500602 0.893 rs6500598 chr16:4470964 G/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 6.84 0.35 3.68e-11 Schizophrenia; LUSC trans rs2975734 0.676 rs4841299 chr8:10112593 A/C cg15556689 chr8:8085844 FLJ10661 -0.5 -6.33 -0.33 7.9e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs11971779 0.680 rs4732370 chr7:139077240 A/C cg07862535 chr7:139043722 LUC7L2 -0.54 -6.75 -0.35 6.59e-11 Diisocyanate-induced asthma; LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg22920501 chr2:26401640 FAM59B 0.73 9.97 0.48 1.14e-20 Gut microbiome composition (summer); LUSC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg19622623 chr12:86230825 RASSF9 -0.41 -5.66 -0.3 3.31e-8 Major depressive disorder; LUSC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg03806693 chr22:41940476 POLR3H 0.99 13.72 0.6 2.7200000000000002e-34 Vitiligo; LUSC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg19257562 chr1:2043853 PRKCZ 0.32 6.46 0.33 3.77e-10 Height; LUSC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg06808227 chr14:105710500 BRF1 -0.68 -10.42 -0.5 3.37e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs17095355 0.901 rs61881586 chr10:111758419 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.35 -0.37 1.53e-12 Biliary atresia; LUSC cis rs9660992 0.539 rs113699533 chr1:205122895 G/A cg00857998 chr1:205179979 DSTYK 0.67 10.68 0.5 4.31e-23 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11644478 chr21:40555479 PSMG1 0.9 16.31 0.67 2.14e-44 Cognitive function; LUSC cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.12 -0.45 7.12e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.59 0.57 5.28e-30 Prudent dietary pattern; LUSC cis rs7954584 0.635 rs11043242 chr12:122356293 G/C cg21016266 chr12:122356598 WDR66 0.6 8.83 0.44 5.82e-17 Mean corpuscular volume; LUSC cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.16e-8 Major depressive disorder; LUSC cis rs1538970 0.962 rs9429158 chr1:45821393 A/G cg05343316 chr1:45956843 TESK2 0.59 8.22 0.41 4.53e-15 Platelet count; LUSC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -7.59 -0.38 3.15e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs13242816 1.000 rs55833477 chr7:116110375 C/G cg16553024 chr7:116138462 CAV2 -0.54 -5.92 -0.31 7.84e-9 P wave duration; LUSC cis rs7267979 0.932 rs6037125 chr20:25463382 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.12 0.74 1.49e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg00343986 chr7:65444356 GUSB -0.48 -7.2 -0.37 3.97e-12 Aortic root size; LUSC cis rs17102423 0.594 rs1124752 chr14:65567515 G/T cg11161011 chr14:65562177 MAX -0.71 -10.78 -0.51 1.95e-23 Obesity-related traits; LUSC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg13798780 chr7:105162888 PUS7 -0.53 -6.0 -0.31 4.99e-9 Bipolar disorder (body mass index interaction); LUSC cis rs3772130 0.923 rs7649092 chr3:121561950 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 9.98 0.48 1.09e-20 Cognitive performance; LUSC cis rs793571 0.502 rs387812 chr15:59074786 T/C cg05156742 chr15:59063176 FAM63B 0.55 8.74 0.43 1.14e-16 Schizophrenia; LUSC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg21770322 chr7:97807741 LMTK2 0.43 7.38 0.37 1.26e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs13126694 0.650 rs10028808 chr4:158860640 T/C cg07447742 chr13:49793170 MLNR -0.29 -6.09 -0.32 3.07e-9 Blood osmolality (transformed sodium); LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg08470875 chr2:26401718 FAM59B -0.69 -9.37 -0.46 1.16e-18 Gut microbiome composition (summer); LUSC cis rs2456568 0.548 rs6483281 chr11:93661840 G/C cg17595323 chr11:93583763 C11orf90 -0.31 -5.67 -0.3 3.09e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs12586317 0.620 rs10145433 chr14:35583333 G/A cg05294307 chr14:35346193 BAZ1A -0.57 -7.05 -0.36 1.03e-11 Psoriasis; LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg08280861 chr8:58055591 NA 0.54 6.44 0.33 4.06e-10 Developmental language disorder (linguistic errors); LUSC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg04352962 chr1:209979756 IRF6 0.49 6.3 0.33 9.27e-10 Cleft lip with or without cleft palate; LUSC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg14784868 chr12:69753453 YEATS4 0.82 14.29 0.62 1.77e-36 Blood protein levels; LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg04518342 chr5:131593106 PDLIM4 0.42 7.47 0.38 7.28e-13 Breast cancer; LUSC cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg03146154 chr1:46216737 IPP -0.51 -7.36 -0.37 1.47e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs17604090 1.000 rs17661938 chr7:29693378 C/T cg19413766 chr7:29689036 LOC646762 -0.62 -7.46 -0.38 7.31e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC trans rs853679 0.517 rs3757185 chr6:28107776 T/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.1 -0.32 2.97e-9 Depression; LUSC cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg05535760 chr7:792225 HEATR2 0.8 9.81 0.47 4.05e-20 Cerebrospinal P-tau181p levels; LUSC cis rs9318086 0.712 rs9318099 chr13:24442462 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.43 -6.56 -0.34 2.11e-10 Myopia (pathological); LUSC cis rs7589342 0.839 rs1465641 chr2:106438936 C/T cg16077055 chr2:106428750 NCK2 0.37 7.0 0.36 1.43e-11 Addiction; LUSC cis rs1451375 0.583 rs3807555 chr7:50610569 A/G cg18232548 chr7:50535776 DDC 0.52 7.0 0.36 1.39e-11 Malaria; LUSC trans rs4927850 1.000 rs10881563 chr3:195750225 A/G cg16724585 chr3:197361211 NA -0.6 -8.45 -0.42 9.04e-16 Pancreatic cancer; LUSC cis rs34779708 0.900 rs73262807 chr10:35496386 C/T cg04310649 chr10:35416472 CREM -0.41 -6.32 -0.33 8.17e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6087990 0.735 rs6087420 chr20:31359391 G/A cg13636640 chr20:31349939 DNMT3B 0.94 19.71 0.73 6.5e-58 Ulcerative colitis; LUSC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.65 0.3 3.37e-8 Self-reported allergy; LUSC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg17366294 chr4:99064904 C4orf37 0.59 10.51 0.5 1.68e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg16447950 chr5:562315 NA -0.57 -7.04 -0.36 1.12e-11 Obesity-related traits; LUSC trans rs61931739 0.500 rs34703942 chr12:34583776 T/C cg13010199 chr12:38710504 ALG10B -0.56 -8.82 -0.43 6.69e-17 Morning vs. evening chronotype; LUSC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg23711669 chr6:146136114 FBXO30 -0.84 -15.22 -0.64 4.21e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg12011299 chr4:100065546 ADH4 0.61 9.71 0.47 8.65e-20 Alcohol dependence; LUSC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg11764359 chr7:65958608 NA 0.68 11.06 0.52 2e-24 Aortic root size; LUSC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg14004847 chr7:1930337 MAD1L1 -0.5 -7.35 -0.37 1.51e-12 Bipolar disorder and schizophrenia; LUSC cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg14582100 chr15:45693742 SPATA5L1 0.58 10.56 0.5 1.11e-22 Homoarginine levels; LUSC cis rs11148252 0.740 rs9526914 chr13:52976300 G/T cg02158880 chr13:53174818 NA 0.39 5.99 0.31 5.46e-9 Lewy body disease; LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.31 -0.41 2.51e-15 Obesity-related traits; LUSC cis rs28647808 0.786 rs28458971 chr9:136255736 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs11622475 0.580 rs36026329 chr14:104351661 T/A cg12183467 chr14:104352244 NA -0.5 -10.1 -0.48 4.19e-21 Bipolar disorder; LUSC cis rs16976116 0.901 rs1061821 chr15:55496111 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg10883421 chr6:151773342 RMND1;C6orf211 0.77 13.52 0.59 1.6e-33 Menarche (age at onset); LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.72 11.13 0.52 1.1e-24 Lymphocyte counts; LUSC cis rs1994135 0.669 rs11052746 chr12:33697473 A/C cg06521331 chr12:34319734 NA 0.39 5.74 0.3 2.14e-8 Resting heart rate; LUSC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.6 -0.43 3.08e-16 Personality dimensions; LUSC cis rs8028313 0.630 rs28565266 chr15:67938011 C/G cg08079166 chr15:68083412 MAP2K5 0.36 6.2 0.32 1.7e-9 Obesity; LUSC cis rs240764 0.658 rs9322183 chr6:101225121 G/A cg09795085 chr6:101329169 ASCC3 -0.45 -6.33 -0.33 8e-10 Neuroticism; LUSC cis rs743757 1.000 rs2236964 chr3:50449062 C/G cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.37 -5.8 -0.3 1.55e-8 Diastolic blood pressure; LUSC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -9.74 -0.47 6.52e-20 Schizophrenia; LUSC cis rs7582180 0.638 rs7581011 chr2:100954659 A/G cg12002119 chr2:101014098 CHST10 -0.35 -5.86 -0.31 1.1e-8 Intelligence (multi-trait analysis); LUSC cis rs73206853 0.688 rs57837519 chr12:110961082 C/T cg12870014 chr12:110450643 ANKRD13A 0.49 5.86 0.31 1.11e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg00049323 chr5:472564 LOC25845 -0.41 -6.16 -0.32 2.07e-9 Cystic fibrosis severity; LUSC cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg13298116 chr11:62369859 EML3;MTA2 0.58 9.33 0.45 1.47e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs9886428 1.000 rs34062482 chr8:14115734 A/C cg19037007 chr20:741798 C20orf54 -0.4 -6.29 -0.33 9.78e-10 IgG glycosylation; LUSC cis rs1371867 0.846 rs1660316 chr8:101333049 T/C cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.15 0.49 2.74e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6964587 1.000 rs2282974 chr7:91761617 G/A cg17063962 chr7:91808500 NA 0.61 9.61 0.47 1.78e-19 Breast cancer; LUSC cis rs908922 0.676 rs526099 chr1:152497811 T/C cg20991723 chr1:152506922 NA 0.53 9.76 0.47 5.9e-20 Hair morphology; LUSC cis rs12493885 0.818 rs55681005 chr3:153759257 G/T cg17054900 chr3:154042577 DHX36 -0.75 -7.65 -0.39 2.18e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg24578937 chr1:2090814 PRKCZ -0.44 -9.86 -0.47 2.77e-20 Height; LUSC cis rs6728642 0.708 rs56807297 chr2:97861340 A/C cg26665480 chr2:98280029 ACTR1B -0.73 -5.73 -0.3 2.19e-8 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs2952156 0.959 rs907087 chr17:37828787 G/A cg00129232 chr17:37814104 STARD3 -0.43 -6.36 -0.33 6.8e-10 Asthma; LUSC cis rs1559088 0.947 rs7256182 chr19:33558591 G/A cg27124370 chr19:33622961 WDR88 0.53 6.69 0.34 9.21e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7973719 0.966 rs1450962 chr12:7320545 A/G cg07052231 chr12:7363540 PEX5 0.52 8.84 0.44 5.49e-17 IgG glycosylation; LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg04871131 chr7:94954202 PON1 -0.38 -6.08 -0.32 3.2e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg27588902 chr6:42928151 GNMT -0.3 -6.6 -0.34 1.65e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs377070 0.934 rs309396 chr4:123614282 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.47 6.79 0.35 5.04e-11 Mosquito bite size; LUSC cis rs2235649 0.592 rs7197113 chr16:1969483 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -5.65 -0.3 3.51e-8 Blood metabolite levels; LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg11062466 chr8:58055876 NA 0.72 8.93 0.44 2.94e-17 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg11645453 chr3:52864694 ITIH4 0.34 8.09 0.4 1.13e-14 Bipolar disorder; LUSC cis rs7927592 0.513 rs531163 chr11:68194496 A/G cg01657329 chr11:68192670 LRP5 -0.47 -7.27 -0.37 2.52e-12 Total body bone mineral density; LUSC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -5.64 -0.3 3.55e-8 Personality dimensions; LUSC cis rs12530845 1.000 rs4291211 chr7:135335373 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.73 -0.47 7.38e-20 Red blood cell traits; LUSC cis rs7474896 0.583 rs10740950 chr10:38003496 C/T cg25427524 chr10:38739819 LOC399744 -0.49 -6.8 -0.35 4.98e-11 Obesity (extreme); LUSC cis rs4808199 0.948 rs8108647 chr19:19427623 A/G cg03709012 chr19:19516395 GATAD2A 0.97 11.95 0.55 1.16e-27 Nonalcoholic fatty liver disease; LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg02951883 chr7:2050386 MAD1L1 -0.39 -6.72 -0.35 7.86e-11 Bipolar disorder and schizophrenia; LUSC cis rs1670533 1.000 rs13135215 chr4:1054364 A/G cg02018176 chr4:1364513 KIAA1530 0.44 6.07 0.32 3.49e-9 Recombination rate (females); LUSC cis rs7215564 0.908 rs35646299 chr17:78653506 T/G cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs6500602 0.893 rs6500596 chr16:4470027 G/T cg08645402 chr16:4508243 NA 0.53 8.18 0.41 6.1e-15 Schizophrenia; LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg27094323 chr7:1216898 NA -0.36 -6.31 -0.33 8.92e-10 Longevity;Endometriosis; LUSC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg20503657 chr10:835505 NA 0.85 12.05 0.55 5.19e-28 Eosinophil percentage of granulocytes; LUSC cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg17420585 chr12:42539391 GXYLT1 -0.37 -7.08 -0.36 8.62e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg23711669 chr6:146136114 FBXO30 0.82 14.37 0.62 8.27e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.56 -8.75 -0.43 1.1e-16 Lymphocyte counts; LUSC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.35 -7.53 -0.38 4.67e-13 Cystic fibrosis severity; LUSC cis rs8114671 0.662 rs6088664 chr20:33551100 G/A cg24642439 chr20:33292090 TP53INP2 0.44 6.45 0.33 3.92e-10 Height; LUSC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg15506890 chr2:3487001 NA -0.58 -9.5 -0.46 4.21e-19 Neurofibrillary tangles; LUSC cis rs6496667 0.557 rs2589951 chr15:90958392 T/C cg22089800 chr15:90895588 ZNF774 0.54 7.88 0.4 4.76e-14 Rheumatoid arthritis; LUSC cis rs9467773 0.620 rs2494692 chr6:26615223 G/A cg11502198 chr6:26597334 ABT1 0.7 11.72 0.54 8.63e-27 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.757 rs4793954 chr17:56629527 G/T cg05425664 chr17:57184151 TRIM37 0.55 7.75 0.39 1.08e-13 Intelligence (multi-trait analysis); LUSC cis rs11608355 1.000 rs9669684 chr12:109860644 C/T cg19025524 chr12:109796872 NA -0.38 -5.96 -0.31 6.58e-9 Neuroticism; LUSC cis rs6121246 0.909 rs6060793 chr20:30288830 T/G cg13852791 chr20:30311386 BCL2L1 0.88 11.88 0.55 2.12e-27 Mean corpuscular hemoglobin; LUSC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg17971929 chr21:40555470 PSMG1 -0.63 -10.27 -0.49 1.12e-21 Cognitive function; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg10360139 chr7:1886902 MAD1L1 -0.45 -6.96 -0.36 1.83e-11 Bipolar disorder and schizophrenia; LUSC cis rs7674212 0.539 rs6533056 chr4:104120997 T/C cg16532752 chr4:104119610 CENPE -0.47 -6.8 -0.35 4.81e-11 Type 2 diabetes; LUSC cis rs3087591 0.919 rs2012581 chr17:29560800 A/G cg24425628 chr17:29625626 OMG;NF1 -0.6 -8.75 -0.43 1.09e-16 Hip circumference; LUSC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg05082376 chr22:42548792 NA 0.43 6.5 0.33 2.98e-10 Schizophrenia; LUSC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg11645453 chr3:52864694 ITIH4 0.37 8.32 0.41 2.23e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs6964587 1.000 rs6968870 chr7:91661111 G/C cg17063962 chr7:91808500 NA 0.6 9.22 0.45 3.41e-18 Breast cancer; LUSC cis rs7799006 0.929 rs35629140 chr7:2257171 G/C cg02951883 chr7:2050386 MAD1L1 -0.37 -6.22 -0.32 1.52e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2273669 0.588 rs114414265 chr6:109306489 C/A cg05315195 chr6:109294784 ARMC2 -0.55 -6.21 -0.32 1.62e-9 Prostate cancer; LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg18404041 chr3:52824283 ITIH1 -0.57 -11.03 -0.52 2.41e-24 Bipolar disorder; LUSC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg20135002 chr11:47629003 NA -0.52 -8.16 -0.41 7.03e-15 Subjective well-being; LUSC cis rs11098499 0.955 rs35197422 chr4:120169314 T/G cg09307838 chr4:120376055 NA 0.69 9.98 0.48 1.05e-20 Corneal astigmatism; LUSC cis rs2806974 0.608 rs1322938 chr13:53731757 A/G cg14823544 chr13:53775958 NA -0.33 -5.68 -0.3 2.96e-8 Trans fatty acid levels; LUSC cis rs853679 0.546 rs17695758 chr6:27837183 T/C cg26958806 chr6:27640298 NA 0.83 6.57 0.34 1.94e-10 Depression; LUSC trans rs2243480 1.000 rs6974723 chr7:65637939 C/T cg10756647 chr7:56101905 PSPH -0.82 -8.16 -0.41 6.72e-15 Diabetic kidney disease; LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg10802521 chr3:52805072 NEK4 -0.55 -8.71 -0.43 1.38e-16 Bipolar disorder; LUSC cis rs6494488 0.500 rs72742987 chr15:64993757 T/C cg08069370 chr15:64387884 SNX1 -0.68 -5.9 -0.31 8.97e-9 Coronary artery disease; LUSC cis rs12802244 1 rs12802244 chr11:47932666 G/A cg20307385 chr11:47447363 PSMC3 -0.43 -5.66 -0.3 3.24e-8 Neuroticism; LUSC cis rs208520 0.837 rs208486 chr6:66926255 A/T cg07460842 chr6:66804631 NA -1.03 -14.46 -0.62 3.7e-37 Exhaled nitric oxide output; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.0 -0.58 1.54e-31 Platelet count; LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.65 14.11 0.61 8.97e-36 Hemoglobin concentration; LUSC cis rs4253772 0.701 rs9627280 chr22:46643964 T/C cg24881330 chr22:46731750 TRMU 0.68 8.26 0.41 3.54e-15 LDL cholesterol;Cholesterol, total; LUSC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg10253484 chr15:75165896 SCAMP2 0.49 7.24 0.37 3.12e-12 Breast cancer; LUSC cis rs11690935 0.851 rs10174055 chr2:172858214 C/T cg13550731 chr2:172543902 DYNC1I2 -0.79 -12.39 -0.56 2.84e-29 Schizophrenia; LUSC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg00310523 chr12:86230176 RASSF9 0.49 9.26 0.45 2.64e-18 Major depressive disorder; LUSC cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC trans rs236907 0.859 rs12730717 chr1:171756515 C/T cg13482142 chr2:234261155 NA 0.48 5.96 0.31 6.35e-9 Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08484668 chr6:157472027 ARID1B 0.47 6.75 0.35 6.49e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg03146154 chr1:46216737 IPP 0.52 7.65 0.39 2.11e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg14844989 chr11:31128820 NA 0.37 5.81 0.3 1.47e-8 Red blood cell count; LUSC cis rs921665 1.000 rs921665 chr2:3174321 A/G cg16434511 chr2:3151078 NA -0.48 -5.82 -0.3 1.41e-8 World class endurance athleticism; LUSC cis rs1882538 0.538 rs7803848 chr7:133108547 C/T cg10665199 chr7:133106180 EXOC4 0.55 7.95 0.4 2.9e-14 Intelligence (multi-trait analysis); LUSC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg12641515 chr19:46296257 DMWD 0.48 7.21 0.37 3.84e-12 Coronary artery disease; LUSC cis rs4474465 0.850 rs7117513 chr11:78206418 T/G cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs9303401 0.659 rs34913878 chr17:56897094 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.34 0.59 7.79e-33 Cognitive test performance; LUSC cis rs8133932 0.608 rs403192 chr21:47360641 C/T cg14185626 chr21:47401492 COL6A1 -0.45 -5.69 -0.3 2.81e-8 Schizophrenia; LUSC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4065321 0.609 rs8075668 chr17:38137623 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.57 9.86 0.47 2.63e-20 White blood cell count (basophil);White blood cell count; LUSC cis rs9399135 0.660 rs4440481 chr6:135276696 A/G cg24558204 chr6:135376177 HBS1L 0.56 8.5 0.42 6.4e-16 Red blood cell count; LUSC cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.43e-32 Chronic sinus infection; LUSC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg22532475 chr10:104410764 TRIM8 -0.34 -6.59 -0.34 1.67e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9393777 0.777 rs35984974 chr6:27410422 G/A cg26335602 chr6:28129616 ZNF389 0.65 5.98 0.31 5.69e-9 Intelligence (multi-trait analysis); LUSC trans rs12579753 1.000 rs12821073 chr12:82183260 G/T cg07923666 chr12:49932857 KCNH3 -0.49 -6.08 -0.32 3.33e-9 Resting heart rate; LUSC cis rs2299587 0.585 rs2285304 chr8:17797931 T/A cg01800426 chr8:17659068 MTUS1 -0.49 -6.54 -0.34 2.33e-10 Economic and political preferences; LUSC cis rs7833986 1.000 rs7833986 chr8:57100149 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.54 8.43 0.42 1.04e-15 Height; LUSC cis rs4969178 0.832 rs4969185 chr17:76398157 G/C cg05887092 chr17:76393375 PGS1 0.54 9.77 0.47 5.3e-20 HDL cholesterol levels; LUSC cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg05585544 chr11:47624801 NA -0.4 -6.93 -0.35 2.24e-11 Subjective well-being; LUSC cis rs12824058 1.000 rs12824058 chr12:130804334 A/G cg26677194 chr12:130822605 PIWIL1 0.58 8.72 0.43 1.31e-16 Menopause (age at onset); LUSC trans rs10802346 0.514 rs4443861 chr1:246372574 G/T cg13514129 chr1:39547527 MACF1 0.72 11.83 0.54 3.36e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs12530845 0.887 rs78641973 chr7:135324311 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.07 -0.44 1.01e-17 Red blood cell traits; LUSC cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg05347473 chr6:146136440 FBXO30 0.42 7.22 0.37 3.47e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC cis rs6693567 0.545 rs2275246 chr1:150460168 A/G cg15654264 chr1:150340011 RPRD2 0.43 6.93 0.35 2.16e-11 Migraine; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.59 0.5 8.51e-23 Alzheimer's disease; LUSC cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.61 0.65 1.27e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs9473147 0.516 rs9296561 chr6:47488938 G/A cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09352908 chr3:37017749 NA 0.5 6.03 0.31 4.45e-9 Bipolar disorder and schizophrenia; LUSC trans rs11992162 0.613 rs6601634 chr8:11806456 T/C cg27411982 chr8:10470053 RP1L1 -0.43 -6.44 -0.33 4.13e-10 Monocyte count; LUSC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg22105103 chr4:187893119 NA -0.67 -12.72 -0.57 1.66e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs11155671 0.530 rs9371215 chr6:150194298 C/T cg07701084 chr6:150067640 NUP43 0.46 6.88 0.35 3.01e-11 Testicular germ cell tumor; LUSC trans rs7824557 0.767 rs10104728 chr8:11171300 A/G cg15556689 chr8:8085844 FLJ10661 0.55 8.54 0.42 4.96e-16 Retinal vascular caliber; LUSC cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg05340658 chr4:99064831 C4orf37 0.59 7.91 0.4 3.82e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9902453 0.753 rs3097118 chr17:27978466 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.01 0.52 2.87e-24 Coffee consumption (cups per day); LUSC cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg11266682 chr4:10021025 SLC2A9 0.55 9.86 0.47 2.68e-20 Bone mineral density; LUSC cis rs654950 0.743 rs115951861 chr1:41992488 C/T cg06885757 chr1:42089581 HIVEP3 -0.37 -7.28 -0.37 2.38e-12 Airway imaging phenotypes; LUSC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6845621 0.901 rs4697202 chr4:18920624 A/G cg12196642 chr4:18937545 NA -0.34 -6.47 -0.33 3.48e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg14668632 chr7:2872130 GNA12 -0.46 -6.71 -0.34 8.2e-11 Height; LUSC cis rs1878931 0.507 rs67218524 chr16:3403057 G/T cg22508957 chr16:3507546 NAT15 0.44 6.21 0.32 1.56e-9 Body mass index (adult); LUSC trans rs11723530 0.538 rs6419975 chr4:170807934 T/G cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.17 -0.32 2e-9 Myopia (pathological); LUSC cis rs12618769 1.000 rs72825732 chr2:99259778 T/C cg10123293 chr2:99228465 UNC50 0.43 5.96 0.31 6.29e-9 Bipolar disorder; LUSC cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg13319975 chr6:146136371 FBXO30 0.51 7.6 0.38 2.98e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.89 0.44 3.86e-17 Schizophrenia; LUSC cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg24642439 chr20:33292090 TP53INP2 -0.5 -7.48 -0.38 6.76e-13 Glomerular filtration rate (creatinine); LUSC cis rs12291225 0.753 rs1431374 chr11:14303975 T/C cg19336497 chr11:14380999 RRAS2 -0.56 -11.56 -0.53 3.23e-26 Sense of smell; LUSC cis rs807669 0.903 rs762527 chr22:19183470 A/G cg02655711 chr22:19163373 SLC25A1 0.91 17.89 0.7 1.14e-50 Metabolite levels; LUSC cis rs796364 0.951 rs7586320 chr2:201068209 C/G cg23649088 chr2:200775458 C2orf69 0.49 6.77 0.35 5.85e-11 Schizophrenia; LUSC cis rs7824557 0.606 rs2736273 chr8:11199938 C/A cg21775007 chr8:11205619 TDH 0.78 12.6 0.57 4.65e-30 Retinal vascular caliber; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24517800 chr6:42989357 C6orf153 -0.44 -6.53 -0.34 2.49e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10078 0.571 rs890977 chr5:476910 T/C cg08916839 chr5:415575 AHRR 0.76 7.11 0.36 6.97e-12 Fat distribution (HIV); LUSC cis rs6733011 0.628 rs1983352 chr2:99454227 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.56 -0.34 2.01e-10 Bipolar disorder; LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.73 -0.57 1.58e-30 Alzheimer's disease; LUSC cis rs3820928 0.874 rs6717168 chr2:227901342 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.81 -0.39 7.61e-14 Pulmonary function; LUSC trans rs61931739 0.517 rs11513277 chr12:34074799 G/T cg26384229 chr12:38710491 ALG10B 0.72 11.37 0.53 1.52e-25 Morning vs. evening chronotype; LUSC cis rs981844 1.000 rs62325105 chr4:154673846 T/C cg14289246 chr4:154710475 SFRP2 0.5 6.44 0.33 4.05e-10 Response to statins (LDL cholesterol change); LUSC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg23625390 chr15:77176239 SCAPER 0.5 7.67 0.39 1.92e-13 Blood metabolite levels; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg11965913 chr1:205819406 PM20D1 0.93 19.08 0.72 2.06e-55 Menarche (age at onset); LUSC cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.88 0.51 8.56e-24 Bladder cancer; LUSC cis rs11158026 0.757 rs72715573 chr14:55459571 C/T cg04306507 chr14:55594613 LGALS3 0.37 7.19 0.37 4.15e-12 Parkinson's disease; LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg11062466 chr8:58055876 NA 0.66 8.67 0.43 1.93e-16 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.932 rs11934968 chr4:17667766 A/G cg16339924 chr4:17578868 LAP3 0.55 7.7 0.39 1.52e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13082711 0.871 rs73046194 chr3:27454558 C/T cg02860705 chr3:27208620 NA 0.5 8.54 0.42 4.67e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg13126279 chr21:47581558 C21orf56 -0.5 -7.52 -0.38 4.98e-13 Testicular germ cell tumor; LUSC cis rs9549260 0.755 rs9577091 chr13:41227865 G/A cg21288729 chr13:41239152 FOXO1 0.64 9.97 0.48 1.12e-20 Red blood cell count; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg25703541 chr22:24373054 LOC391322 0.81 14.24 0.61 2.85e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05360402 chr5:110848191 STARD4 0.42 6.45 0.33 3.92e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs61931739 0.500 rs7311302 chr12:34557211 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs2777491 0.915 rs7180418 chr15:41629502 A/C cg18705301 chr15:41695430 NDUFAF1 -0.76 -14.31 -0.62 1.43e-36 Ulcerative colitis; LUSC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.66 -0.39 2.04e-13 Intelligence (multi-trait analysis); LUSC cis rs701145 0.585 rs1713810 chr3:153876826 C/T cg17054900 chr3:154042577 DHX36 -0.53 -5.69 -0.3 2.82e-8 Coronary artery disease; LUSC cis rs6547741 0.935 rs4666005 chr2:27855239 A/G cg12559939 chr2:27858050 GPN1 0.39 6.03 0.31 4.39e-9 Oral cavity cancer; LUSC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg17376030 chr22:41985996 PMM1 -0.48 -5.99 -0.31 5.37e-9 Vitiligo; LUSC cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -6.9 -0.35 2.58e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs5758511 0.573 rs5996069 chr22:42201185 T/G cg00645731 chr22:42541494 CYP2D7P1 -0.39 -7.47 -0.38 7.22e-13 Birth weight; LUSC cis rs12220238 1.000 rs10824106 chr10:75958408 C/T cg19889307 chr10:75911429 ADK;AP3M1 -0.6 -6.51 -0.34 2.74e-10 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.75 0.39 1.1e-13 Parkinson's disease; LUSC cis rs2307022 0.586 rs10852441 chr16:68385439 T/A cg02226672 chr16:68398533 SMPD3 0.3 5.69 0.3 2.81e-8 Body mass index; LUSC cis rs3862030 0.720 rs3740414 chr10:104232809 T/G cg05855489 chr10:104503620 C10orf26 0.49 7.36 0.37 1.46e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs3736594 0.513 rs78170284 chr2:27835082 G/A cg27432699 chr2:27873401 GPN1 0.65 8.55 0.42 4.5e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2487048 0.725 rs2246293 chr9:107690838 C/G cg14019050 chr9:107690770 ABCA1 0.27 5.67 0.3 3.17e-8 Intraocular pressure; LUSC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg11657440 chr19:46296263 DMWD 0.88 16.75 0.68 3.92e-46 Coronary artery disease; LUSC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg23887609 chr12:130822674 PIWIL1 0.49 7.34 0.37 1.64e-12 Menopause (age at onset); LUSC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg21251018 chr6:28226885 NKAPL 0.32 6.02 0.31 4.65e-9 Cardiac Troponin-T levels; LUSC cis rs926938 0.584 rs1286558 chr1:115357587 C/T cg12756093 chr1:115239321 AMPD1 0.48 7.17 0.37 4.86e-12 Autism; LUSC cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.21 0.56 1.32e-28 Colorectal cancer; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg11494091 chr17:61959527 GH2 -0.64 -13.19 -0.59 2.96e-32 Prudent dietary pattern; LUSC cis rs1775715 0.870 rs1251407 chr10:32238325 A/G cg18675610 chr10:32216311 ARHGAP12 0.29 6.2 0.32 1.69e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11051970 0.879 rs2243815 chr12:32576158 C/T cg24626660 chr12:32551988 NA 0.33 5.7 0.3 2.69e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.29 -0.33 9.77e-10 Aortic root size; LUSC cis rs9549260 0.592 rs9315783 chr13:41289164 T/C cg21288729 chr13:41239152 FOXO1 0.55 8.3 0.41 2.7e-15 Red blood cell count; LUSC cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg11058730 chr11:34937778 PDHX;APIP 0.69 11.23 0.52 4.65e-25 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg20302533 chr7:39170763 POU6F2 0.55 9.13 0.45 6.58e-18 IgG glycosylation; LUSC cis rs10986311 0.775 rs7857897 chr9:127118550 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.46 7.32 0.37 1.89e-12 Vitiligo; LUSC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs238295 0.805 rs6053500 chr20:5542683 A/G cg15842884 chr20:5591925 RP5-1022P6.2 -0.43 -5.83 -0.3 1.33e-8 Occipital cortical area (total cortical area interaction); LUSC cis rs6961069 0.538 rs3211886 chr7:80289439 A/G cg04458919 chr7:80252533 CD36 0.38 6.49 0.33 3.04e-10 Platelet count; LUSC cis rs6700896 0.500 rs1938496 chr1:66100915 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.52 6.07 0.32 3.56e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8014204 0.541 rs35591392 chr14:75157713 G/T cg06637938 chr14:75390232 RPS6KL1 0.58 9.16 0.45 5.54e-18 Caffeine consumption; LUSC cis rs13256369 0.708 rs11783670 chr8:8559394 G/A cg18904891 chr8:8559673 CLDN23 0.6 7.9 0.4 4.13e-14 Obesity-related traits; LUSC cis rs17270561 0.609 rs9348695 chr6:25763010 A/T cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs6076065 0.612 rs11905630 chr20:23326165 G/C cg11657817 chr20:23433608 CST11 0.44 8.17 0.41 6.46e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg17063962 chr7:91808500 NA 0.58 9.29 0.45 1.98e-18 Breast cancer; LUSC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg16339924 chr4:17578868 LAP3 0.57 8.75 0.43 1.11e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg12463550 chr7:65579703 CRCP -0.55 -8.03 -0.4 1.68e-14 Aortic root size; LUSC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg24881330 chr22:46731750 TRMU 0.78 7.22 0.37 3.53e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs4851254 0.660 rs4851250 chr2:100729293 T/C cg07810366 chr2:100720526 AFF3 -0.45 -5.89 -0.31 9.37e-9 Intelligence (multi-trait analysis); LUSC cis rs7202877 0.706 rs247425 chr16:75460402 C/T cg04384234 chr16:75411784 CFDP1 0.7 9.72 0.47 7.98e-20 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7615316 1.000 rs6802774 chr3:142351466 G/C cg16271453 chr3:142027066 XRN1 -0.34 -5.82 -0.3 1.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4663866 0.901 rs3739066 chr2:239184124 G/T cg16914508 chr2:239161102 PER2 0.68 7.24 0.37 3.04e-12 Irritable bowel syndrome; LUSC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg27432699 chr2:27873401 GPN1 -0.57 -8.45 -0.42 9.25e-16 Total body bone mineral density; LUSC cis rs7532866 0.885 rs7552065 chr1:26731951 G/T cg17456097 chr1:26900765 RPS6KA1 -0.43 -6.24 -0.32 1.3e-9 Height; LUSC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg06112835 chr11:68658793 MRPL21 0.49 7.35 0.37 1.57e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg14552801 chr7:65878734 NA -0.36 -5.68 -0.3 2.91e-8 Aortic root size; LUSC cis rs16895831 0.519 rs12210135 chr6:42570156 G/T cg10605015 chr6:42532144 UBR2 -0.48 -5.88 -0.31 9.83e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 6.38 0.33 5.95e-10 Bipolar disorder; LUSC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg16049864 chr8:95962084 TP53INP1 -0.68 -13.49 -0.59 2.08e-33 Type 2 diabetes; LUSC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg18876405 chr7:65276391 NA -0.66 -11.66 -0.54 1.34e-26 Aortic root size; LUSC cis rs425277 1.000 rs381664 chr1:2088104 A/G cg24578937 chr1:2090814 PRKCZ 0.6 13.83 0.6 1.07e-34 Height; LUSC cis rs727505 1.000 rs10246424 chr7:124494861 A/G cg23710748 chr7:124431027 NA -0.41 -7.4 -0.38 1.11e-12 Lewy body disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04616222 chr10:99078965 FRAT1 -0.44 -6.74 -0.35 7.04e-11 Electrocardiographic conduction measures; LUSC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg13298116 chr11:62369859 EML3;MTA2 0.53 7.95 0.4 2.87e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.31e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs2762353 0.935 rs1359232 chr6:25809716 C/A cg12310025 chr6:25882481 NA 0.43 7.42 0.38 9.99e-13 Blood metabolite levels; LUSC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg16447950 chr5:562315 NA -0.55 -6.69 -0.34 9.35e-11 Obesity-related traits; LUSC cis rs2014572 0.933 rs8109882 chr19:57755618 C/G cg24459738 chr19:57751996 ZNF805 -0.52 -7.69 -0.39 1.67e-13 Hyperactive-impulsive symptoms; LUSC cis rs9905704 0.681 rs4277402 chr17:56581651 C/G cg12560992 chr17:57184187 TRIM37 -0.49 -5.8 -0.3 1.57e-8 Testicular germ cell tumor; LUSC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg23711669 chr6:146136114 FBXO30 0.91 17.18 0.68 7.46e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs2898290 0.540 rs12677146 chr8:11450737 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.7 -0.39 1.53e-13 Systolic blood pressure; LUSC cis rs9486715 0.867 rs4839834 chr6:96882109 C/A cg06623918 chr6:96969491 KIAA0776 0.93 17.68 0.7 7.64e-50 Headache; LUSC cis rs76878669 0.606 rs2282531 chr11:66099494 C/T cg24851651 chr11:66362959 CCS 0.4 6.43 0.33 4.36e-10 Educational attainment (years of education); LUSC cis rs362272 0.525 rs910568 chr4:3307373 A/G cg18352616 chr4:3374830 RGS12 0.29 5.75 0.3 2.06e-8 Serum sulfate level; LUSC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg20135002 chr11:47629003 NA -0.52 -8.13 -0.41 8.23e-15 Subjective well-being; LUSC cis rs2708377 0.799 rs977474 chr12:11284772 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg14552801 chr7:65878734 NA 0.38 5.74 0.3 2.14e-8 Aortic root size; LUSC cis rs7011049 1.000 rs72640848 chr8:53836225 A/G cg26025543 chr8:53854495 NA 0.5 5.93 0.31 7.37e-9 Systolic blood pressure; LUSC trans rs11098499 0.954 rs6847248 chr4:120225955 A/G cg25214090 chr10:38739885 LOC399744 0.51 7.19 0.37 4.36e-12 Corneal astigmatism; LUSC cis rs3770081 1.000 rs17027011 chr2:86406556 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.87 -6.33 -0.33 7.7e-10 Facial emotion recognition (sad faces); LUSC cis rs73206853 0.841 rs17619763 chr12:110645829 C/T cg12870014 chr12:110450643 ANKRD13A 0.7 6.64 0.34 1.26e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs59918340 0.509 rs11784862 chr8:142203452 T/C cg18755752 chr8:142205143 DENND3 -0.52 -8.01 -0.4 1.99e-14 Immature fraction of reticulocytes; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12756303 chr2:74692479 MOGS 0.38 6.57 0.34 1.89e-10 Asthma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26904999 chr6:166796588 BRP44L -0.42 -6.42 -0.33 4.58e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -11.48 -0.53 6.14e-26 Mean corpuscular volume; LUSC cis rs12477438 0.765 rs2309454 chr2:99595418 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.75 -0.51 2.45e-23 Chronic sinus infection; LUSC cis rs136211 0.599 rs9610497 chr22:36767359 C/T cg21778268 chr22:36877729 TXN2 -0.41 -5.86 -0.31 1.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs10435719 0.902 rs7459983 chr8:11807221 T/C cg15556689 chr8:8085844 FLJ10661 0.6 9.07 0.44 1.03e-17 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1577917 0.740 rs9353320 chr6:86244848 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 7.39 0.37 1.18e-12 Response to antipsychotic treatment; LUSC cis rs977987 0.843 rs62062564 chr16:75442622 G/A cg03315344 chr16:75512273 CHST6 0.53 10.19 0.49 2.13e-21 Dupuytren's disease; LUSC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg04155289 chr7:94953770 PON1 -0.34 -5.69 -0.3 2.72e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2806561 0.754 rs750354 chr1:23297406 T/C cg19743168 chr1:23544995 NA -0.38 -7.91 -0.4 3.79e-14 Height; LUSC cis rs6580649 0.941 rs7312326 chr12:48480643 G/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC trans rs7726839 0.540 rs4957080 chr5:644552 A/C cg11887960 chr12:57824829 NA -0.52 -6.62 -0.34 1.48e-10 Obesity-related traits; LUSC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg04546413 chr19:29218101 NA 0.71 11.45 0.53 7.9e-26 Methadone dose in opioid dependence; LUSC trans rs11992162 0.573 rs13264994 chr8:11782759 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.41 -0.33 5.05e-10 Monocyte count; LUSC cis rs4909189 1.000 rs11764065 chr7:158135974 T/C cg06219351 chr7:158114137 PTPRN2 -0.52 -8.26 -0.41 3.46e-15 Response to amphetamines; LUSC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg17330251 chr7:94953956 PON1 -0.36 -5.86 -0.31 1.08e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9462027 0.628 rs34141614 chr6:34777031 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg20887711 chr4:1340912 KIAA1530 0.43 6.37 0.33 6.12e-10 Obesity-related traits; LUSC trans rs61931739 0.500 rs11053066 chr12:34185318 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.46e-16 Morning vs. evening chronotype; LUSC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.74 -12.87 -0.58 4.48e-31 Total body bone mineral density; LUSC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7202877 0.656 rs4888374 chr16:75322228 T/C cg04384234 chr16:75411784 CFDP1 -0.63 -8.83 -0.44 5.84e-17 Type 2 diabetes;Type 1 diabetes; LUSC trans rs7493138 0.967 rs61984307 chr14:29017635 T/G cg10573181 chr4:170533618 NEK1 0.41 6.05 0.31 3.97e-9 Longevity; LUSC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC cis rs56104184 0.779 rs17206686 chr19:49356317 A/G cg15549821 chr19:49342101 PLEKHA4 -0.88 -11.22 -0.52 5.29e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4746818 1.000 rs7893492 chr10:70960448 C/T cg11621586 chr10:70884670 VPS26A -1.15 -11.44 -0.53 8.66e-26 Left atrial antero-posterior diameter; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg06098346 chr12:48499667 PFKM;SENP1 -0.46 -6.11 -0.32 2.77e-9 Cognitive function;Information processing speed; LUSC cis rs7267979 1.000 rs6050547 chr20:25326012 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.49 -0.33 3.02e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9581857 0.579 rs76657892 chr13:27997604 A/G cg22138327 chr13:27999177 GTF3A 0.83 9.37 0.46 1.1e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg15626777 chr1:38157909 CDCA8 0.43 6.26 0.32 1.18e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg27170947 chr2:26402098 FAM59B -0.63 -9.15 -0.45 5.98e-18 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.17e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs983392 0.805 rs10897011 chr11:59961427 G/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.79 -0.3 1.61e-8 Alzheimer's disease (late onset); LUSC cis rs67460515 0.563 rs11717272 chr3:160810355 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.31 -0.33 9.01e-10 Parkinson's disease; LUSC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.99 0.36 1.49e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs8060686 0.545 rs12600062 chr16:68287544 C/A cg27539214 chr16:67997921 SLC12A4 -0.58 -6.65 -0.34 1.21e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs6964587 1.000 rs55745934 chr7:91670998 T/C cg22709100 chr7:91322751 NA 0.42 6.14 0.32 2.39e-9 Breast cancer; LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7954584 0.546 rs10840630 chr12:122352445 C/T cg21171335 chr12:122356390 WDR66 0.63 9.27 0.45 2.34e-18 Mean corpuscular volume; LUSC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg13206674 chr6:150067644 NUP43 0.61 9.65 0.47 1.39e-19 Lung cancer; LUSC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg12257692 chr3:49977190 RBM6 0.24 6.61 0.34 1.53e-10 Body mass index; LUSC cis rs6733011 0.519 rs11900176 chr2:99463536 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.42 5.8 0.3 1.58e-8 Bipolar disorder; LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.37 -0.33 6.35e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7681440 0.904 rs6532192 chr4:90764131 G/A cg20003494 chr4:90757398 SNCA -0.33 -5.71 -0.3 2.5e-8 Dementia with Lewy bodies; LUSC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg17366294 chr4:99064904 C4orf37 0.54 9.5 0.46 4.34e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs1003719 0.762 rs3787786 chr21:38463436 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC trans rs11098499 0.863 rs3775841 chr4:120425777 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.42 0.33 4.68e-10 Corneal astigmatism; LUSC cis rs6977660 0.714 rs12672257 chr7:19813466 C/T cg05791153 chr7:19748676 TWISTNB 0.7 7.4 0.38 1.12e-12 Thyroid stimulating hormone; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg15242686 chr22:24348715 GSTTP1 0.47 7.52 0.38 4.96e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17092148 1.000 rs7271289 chr20:33397303 C/T cg16810054 chr20:33298113 TP53INP2 0.43 6.81 0.35 4.68e-11 Neuroticism; LUSC cis rs10876993 0.928 rs1689595 chr12:58056763 C/T cg18357645 chr12:58087776 OS9 0.55 8.29 0.41 2.83e-15 Celiac disease or Rheumatoid arthritis; LUSC trans rs7829975 0.871 rs777709 chr8:8583872 T/C cg21775007 chr8:11205619 TDH -0.45 -6.42 -0.33 4.58e-10 Mood instability; LUSC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.12 -0.32 2.62e-9 Alzheimer's disease (late onset); LUSC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg20821713 chr7:1055600 C7orf50 0.55 7.44 0.38 8.71e-13 Bronchopulmonary dysplasia; LUSC trans rs4518370 1.000 rs4518370 chr5:82180306 A/G cg14564229 chr9:119748106 ASTN2 -0.38 -5.98 -0.31 5.81e-9 Osteoarthritis biomarkers; LUSC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg27398817 chr8:82754497 SNX16 -0.47 -6.36 -0.33 6.61e-10 Diastolic blood pressure; LUSC cis rs35883536 0.647 rs59667512 chr1:101046712 C/T cg06223162 chr1:101003688 GPR88 -0.47 -8.62 -0.43 2.66e-16 Monocyte count; LUSC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg04025307 chr7:1156635 C7orf50 0.44 6.11 0.32 2.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.11 0.41 9.81e-15 Electroencephalogram traits; LUSC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs13242816 1.000 rs12706090 chr7:116104045 A/G cg16553024 chr7:116138462 CAV2 0.53 5.81 0.3 1.46e-8 P wave duration; LUSC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg21724239 chr8:58056113 NA 0.54 6.6 0.34 1.63e-10 Developmental language disorder (linguistic errors); LUSC trans rs11039798 0.588 rs7479642 chr11:48553808 G/T cg03929089 chr4:120376271 NA 0.6 6.41 0.33 5.03e-10 Axial length; LUSC cis rs7829975 0.560 rs6994131 chr8:8550958 G/A cg15556689 chr8:8085844 FLJ10661 -0.49 -7.08 -0.36 8.32e-12 Mood instability; LUSC cis rs12579753 0.917 rs11610365 chr12:82218108 C/T cg21231944 chr12:82153410 PPFIA2 -0.38 -5.77 -0.3 1.77e-8 Resting heart rate; LUSC cis rs7769051 0.522 rs56908272 chr6:133102165 G/C cg22852734 chr6:133119734 C6orf192 1.32 10.76 0.51 2.26e-23 Type 2 diabetes nephropathy; LUSC cis rs2730245 0.618 rs859781 chr7:158661758 G/A cg24397884 chr7:158709396 WDR60 0.61 9.51 0.46 3.82e-19 Height; LUSC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg23630131 chr7:65973040 NA -0.21 -5.77 -0.3 1.81e-8 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06972182 chr14:56047764 C14orf33;KTN1 0.4 6.06 0.31 3.71e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg00310523 chr12:86230176 RASSF9 0.45 8.34 0.42 2.01e-15 Major depressive disorder; LUSC cis rs9329221 0.527 rs10903328 chr8:10332167 G/C cg21775007 chr8:11205619 TDH 0.44 6.04 0.31 4.02e-9 Neuroticism; LUSC trans rs7937682 0.710 rs674230 chr11:111437887 A/G cg18187862 chr3:45730750 SACM1L 0.6 7.77 0.39 9.8e-14 Primary sclerosing cholangitis; LUSC cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg10351095 chr21:47802916 PCNT -0.43 -6.12 -0.32 2.57e-9 Testicular germ cell tumor; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg10673984 chr17:58677844 PPM1D 0.38 6.4 0.33 5.16e-10 Educational attainment (years of education); LUSC cis rs6445797 0.632 rs11130538 chr3:56700769 A/G cg13792233 chr3:56591045 CCDC66 0.4 5.69 0.3 2.83e-8 Gastritis; LUSC cis rs68092024 0.704 rs793487 chr3:99495422 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 6.62 0.34 1.42e-10 Cleft lip with or without cleft palate; LUSC cis rs17270561 0.609 rs4711097 chr6:25732314 C/T cg16482183 chr6:26056742 HIST1H1C 0.66 9.22 0.45 3.37e-18 Iron status biomarkers; LUSC cis rs9473147 0.516 rs4715018 chr6:47441871 T/C cg12968598 chr6:47444699 CD2AP 0.53 8.06 0.4 1.35e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7017697 0.507 rs10113140 chr8:19684745 A/C cg03894339 chr8:19674705 INTS10 -0.5 -6.87 -0.35 3.23e-11 Breast cancer; LUSC cis rs6912958 0.558 rs7741825 chr6:88327338 G/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -6.08 -0.32 3.24e-9 Monocyte percentage of white cells; LUSC cis rs11958404 0.932 rs72816587 chr5:157434144 T/A cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7818345 1.000 rs4618712 chr8:19302621 A/G cg11303988 chr8:19266685 CSGALNACT1 0.37 7.13 0.36 6.35e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7917772 0.560 rs35095897 chr10:104377759 T/C cg05855489 chr10:104503620 C10orf26 0.49 7.47 0.38 7.01e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg14584255 chr6:163149320 PACRG;PARK2 -0.34 -6.43 -0.33 4.35e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12318506 0.826 rs11180433 chr12:75661470 T/C cg04728562 chr12:75699417 CAPS2 -0.77 -5.93 -0.31 7.49e-9 Coronary artery calcification; LUSC cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.37 -0.37 1.35e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs11719291 0.584 rs13080725 chr3:49076092 G/A cg00383909 chr3:49044727 WDR6 1.36 11.7 0.54 1.01e-26 Cognitive function; LUSC cis rs9341808 0.718 rs9352801 chr6:80817468 G/T cg08355045 chr6:80787529 NA 0.56 9.6 0.46 2.04e-19 Sitting height ratio; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.42e-17 Prudent dietary pattern; LUSC cis rs4851254 0.618 rs35730185 chr2:100648085 G/A cg22139774 chr2:100720529 AFF3 -0.44 -5.79 -0.3 1.65e-8 Intelligence (multi-trait analysis); LUSC trans rs3733585 0.648 rs28513781 chr4:9959334 G/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs17102423 0.964 rs8015330 chr14:65602183 C/T cg11161011 chr14:65562177 MAX -0.65 -10.11 -0.48 3.81e-21 Obesity-related traits; LUSC trans rs804280 0.509 rs9886639 chr8:11784529 G/T cg06636001 chr8:8085503 FLJ10661 0.55 8.14 0.41 7.7e-15 Myopia (pathological); LUSC cis rs983392 0.805 rs7933805 chr11:59967526 A/G cg20284999 chr11:59952153 MS4A6A -0.4 -6.72 -0.35 7.69e-11 Alzheimer's disease (late onset); LUSC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg11645453 chr3:52864694 ITIH4 0.59 14.12 0.61 7.82e-36 Schizophrenia; LUSC cis rs9522267 0.535 rs9522302 chr13:112236874 C/T cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 3e-8 Hepatitis; LUSC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg12560992 chr17:57184187 TRIM37 -0.9 -17.69 -0.7 6.85e-50 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg06064525 chr11:970664 AP2A2 0.49 10.89 0.51 7.88e-24 Alzheimer's disease (late onset); LUSC cis rs9467711 0.606 rs9379858 chr6:26367689 T/C cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs6961069 0.538 rs3211871 chr7:80287358 A/G cg04458919 chr7:80252533 CD36 -0.39 -6.51 -0.34 2.81e-10 Platelet count; LUSC cis rs11112613 0.713 rs73184083 chr12:105952593 T/A cg03607813 chr12:105948248 NA 0.78 11.63 0.54 1.74e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs4942242 1.000 rs9533572 chr13:44234265 A/C cg19169023 chr15:41853346 TYRO3 -0.44 -7.44 -0.38 8.36e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC cis rs1670533 1.000 rs688785 chr4:1082707 G/C cg27284194 chr4:1044797 NA 0.59 8.79 0.43 7.77e-17 Recombination rate (females); LUSC trans rs57046232 0.552 rs6038445 chr20:6329093 A/G cg21095983 chr6:86352623 SYNCRIP 0.5 7.35 0.37 1.49e-12 Colorectal cancer; LUSC trans rs853679 0.607 rs34878803 chr6:28250179 T/C cg01620082 chr3:125678407 NA -0.81 -7.79 -0.39 8.42e-14 Depression; LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 15.03 0.64 2.29e-39 Platelet count; LUSC cis rs13242816 1.000 rs35800776 chr7:116110069 C/A cg16553024 chr7:116138462 CAV2 -0.54 -5.83 -0.3 1.32e-8 P wave duration; LUSC cis rs6121246 0.580 rs6121016 chr20:30245239 C/T cg18721089 chr20:30220636 NA -0.37 -6.2 -0.32 1.63e-9 Mean corpuscular hemoglobin; LUSC cis rs3782089 0.546 rs76146604 chr11:65277512 G/T cg21890820 chr11:65308645 LTBP3 1.4 9.45 0.46 6.03e-19 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16284459 chr7:91510405 MTERF 0.38 6.05 0.31 3.9e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2120019 1.000 rs35736167 chr15:75332002 T/G cg11632617 chr15:75315747 PPCDC -0.5 -6.45 -0.33 4.03e-10 Blood trace element (Zn levels); LUSC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg25072359 chr17:41440525 NA -0.61 -9.04 -0.44 1.34e-17 Menopause (age at onset); LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.57 0.46 2.39e-19 Bipolar disorder; LUSC cis rs9341808 0.683 rs9359409 chr6:80826897 C/G cg08355045 chr6:80787529 NA 0.56 9.85 0.47 2.85e-20 Sitting height ratio; LUSC cis rs7178572 0.889 rs869301 chr15:77830633 T/C cg22256960 chr15:77711686 NA -0.52 -8.46 -0.42 8.69e-16 Type 2 diabetes; LUSC cis rs7666738 0.546 rs13105521 chr4:98734419 C/T cg03676636 chr4:99064102 C4orf37 0.3 5.87 0.31 1.03e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs2067615 0.524 rs7959062 chr12:107107334 G/T cg15890332 chr12:107067104 RFX4 0.35 6.24 0.32 1.34e-9 Heart rate; LUSC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 7.44 0.38 8.66e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9952991 0.883 rs2542147 chr18:12775851 G/T cg23544223 chr18:12777786 NA 0.59 6.25 0.32 1.26e-9 Inflammatory skin disease; LUSC cis rs73206853 0.925 rs61106808 chr12:110876009 C/G cg12870014 chr12:110450643 ANKRD13A 0.5 5.9 0.31 9.03e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs1347297 0.526 rs728005 chr2:179251006 C/T cg14011486 chr1:26737247 LIN28 0.43 6.7 0.34 8.69e-11 Alzheimer disease and age of onset; LUSC cis rs1559088 0.948 rs12608825 chr19:33581219 C/T cg03563238 chr19:33554763 RHPN2 0.4 6.42 0.33 4.68e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.66 0.69 9.01e-50 Chronic sinus infection; LUSC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg07936489 chr17:37558343 FBXL20 0.71 10.08 0.48 4.93e-21 Glomerular filtration rate (creatinine); LUSC trans rs2840044 0.711 rs225301 chr17:33922411 T/A cg19694781 chr19:47549865 TMEM160 -0.8 -12.34 -0.56 4.4e-29 Response to radiotherapy in cancer (late toxicity); LUSC cis rs1371867 0.875 rs1788174 chr8:101330957 C/G cg06002616 chr8:101225028 SPAG1 0.42 6.85 0.35 3.49e-11 Atrioventricular conduction; LUSC cis rs11955175 1.000 rs11954632 chr5:40674929 C/G cg05478818 chr5:40835740 RPL37 0.7 5.77 0.3 1.81e-8 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.41 -0.42 1.21e-15 Lung cancer; LUSC trans rs1493916 0.870 rs8097667 chr18:31387003 C/T cg15819921 chr19:927150 ARID3A -0.42 -6.21 -0.32 1.59e-9 Life satisfaction; LUSC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg16325326 chr1:53192061 ZYG11B 1.04 21.76 0.77 5.48e-66 Monocyte count; LUSC trans rs1941687 0.797 rs1493917 chr18:31392833 G/A cg27147174 chr7:100797783 AP1S1 -0.45 -6.56 -0.34 2.04e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs11711311 1.000 rs1043132 chr3:113528689 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -6.18 -0.32 1.91e-9 IgG glycosylation; LUSC cis rs6736093 0.966 rs11676040 chr2:112713115 T/C cg12686935 chr2:112915763 FBLN7 -0.36 -5.81 -0.3 1.45e-8 Coronary artery disease; LUSC cis rs950173 1.000 rs950173 chr2:172570419 G/A cg13550731 chr2:172543902 DYNC1I2 -0.82 -7.53 -0.38 4.68e-13 Hippocampal volume; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg18000306 chr6:288505 NA -0.34 -6.48 -0.33 3.27e-10 Menopause (age at onset); LUSC cis rs7917772 0.507 rs2778036 chr10:104485725 G/A cg04362960 chr10:104952993 NT5C2 -0.48 -5.74 -0.3 2.18e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.15 0.36 5.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg10018233 chr7:150070692 REPIN1 0.38 6.66 0.34 1.15e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg06850241 chr22:41845214 NA -0.3 -5.65 -0.3 3.38e-8 Vitiligo; LUSC cis rs76525880 0.538 rs9221 chr17:46675813 C/T cg06593406 chr17:46696139 NA -0.69 -5.87 -0.31 1.07e-8 Colorectal or endometrial cancer; LUSC trans rs11250098 0.510 rs4840525 chr8:10765635 C/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.13 -0.36 6.1e-12 Morning vs. evening chronotype; LUSC cis rs3740713 1.000 rs1848048 chr11:18468996 T/C cg23797887 chr11:18477753 LDHAL6A -0.56 -6.77 -0.35 5.8e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7772486 0.776 rs2265467 chr6:146218339 T/A cg13319975 chr6:146136371 FBXO30 -0.47 -7.24 -0.37 3.19e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11644478 chr21:40555479 PSMG1 -0.68 -10.77 -0.51 2.11e-23 Menarche (age at onset); LUSC trans rs459571 0.959 rs465724 chr9:136910097 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.71 -12.01 -0.55 7.02e-28 Platelet distribution width; LUSC cis rs1957429 0.520 rs72625644 chr14:65342282 A/T cg23373153 chr14:65346875 NA -0.9 -7.84 -0.39 5.92e-14 Pediatric areal bone mineral density (radius); LUSC cis rs2540226 0.816 rs4670957 chr2:39980652 C/T cg23576258 chr2:39999331 THUMPD2 0.36 6.2 0.32 1.69e-9 Personality dimensions; LUSC cis rs6424115 1.000 rs4649115 chr1:24155731 A/G cg15997130 chr1:24165203 NA -0.56 -9.2 -0.45 3.94e-18 Immature fraction of reticulocytes; LUSC cis rs3857536 0.741 rs9363558 chr6:66937260 C/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg25036284 chr2:26402008 FAM59B -0.74 -10.51 -0.5 1.66e-22 Gut microbiome composition (summer); LUSC cis rs870825 0.616 rs10022818 chr4:185619282 A/G cg04058563 chr4:185651563 MLF1IP 0.86 13.39 0.59 5.13e-33 Blood protein levels; LUSC cis rs11122272 0.735 rs2437150 chr1:231488524 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.64 10.48 0.5 2.07e-22 Hemoglobin concentration; LUSC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg25554036 chr4:6271136 WFS1 0.6 12.55 0.57 7.26e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs58785573 1.000 rs58785573 chr4:38653773 A/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.41 6.18 0.32 1.91e-9 Lymphocyte percentage of white cells; LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs7107174 1.000 rs7119933 chr11:78049750 A/C cg02023728 chr11:77925099 USP35 0.4 6.22 0.32 1.52e-9 Testicular germ cell tumor; LUSC cis rs7851660 0.874 rs7868534 chr9:100632606 G/A cg13688889 chr9:100608707 NA -0.56 -8.91 -0.44 3.48e-17 Strep throat; LUSC cis rs1113500 0.897 rs2336127 chr1:108640870 G/A cg06207961 chr1:108661230 NA 0.42 7.8 0.39 7.93e-14 Growth-regulated protein alpha levels; LUSC cis rs231513 0.906 rs1642611 chr17:41997712 T/C cg26893861 chr17:41843967 DUSP3 -0.59 -6.28 -0.33 1.02e-9 Cognitive function; LUSC cis rs8099014 1.000 rs4640266 chr18:56131865 T/G cg12907477 chr18:56117327 MIR122 0.44 6.86 0.35 3.35e-11 Platelet count; LUSC cis rs13031619 0.517 rs10864995 chr2:3683557 C/T cg25251562 chr2:3704773 ALLC -0.49 -6.56 -0.34 2.07e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7000551 0.581 rs2293145 chr8:22262654 A/T cg12081754 chr8:22256438 SLC39A14 0.94 14.61 0.62 9.98e-38 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs28647808 0.881 rs41297211 chr9:136260721 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg18240062 chr17:79603768 NPLOC4 0.56 9.75 0.47 6.3e-20 Eye color traits; LUSC cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg12165864 chr7:66369176 NA -0.53 -7.14 -0.36 5.85e-12 Corneal structure; LUSC cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg06552810 chr11:31128660 NA -0.4 -7.13 -0.36 6.38e-12 Red blood cell count; LUSC cis rs9303401 0.659 rs12940212 chr17:56674474 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.78 0.57 9.84e-31 Cognitive test performance; LUSC cis rs8062405 0.723 rs35175818 chr16:28608746 A/C cg16576597 chr16:28551801 NUPR1 0.33 6.57 0.34 1.91e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9325144 0.671 rs12818797 chr12:39019409 A/G cg13010199 chr12:38710504 ALG10B -0.51 -7.7 -0.39 1.53e-13 Morning vs. evening chronotype; LUSC cis rs7605827 0.930 rs6431708 chr2:15638175 C/T cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.74e-17 Educational attainment (years of education); LUSC trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.47 -7.02 -0.36 1.27e-11 Alzheimer's disease (late onset); LUSC trans rs12579753 0.917 rs10129029 chr12:82180324 G/A cg07923666 chr12:49932857 KCNH3 -0.49 -6.16 -0.32 2.09e-9 Resting heart rate; LUSC cis rs868036 0.718 rs8025790 chr15:68076399 G/T cg24579218 chr15:68104479 NA -0.37 -6.63 -0.34 1.34e-10 Restless legs syndrome; LUSC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg05585544 chr11:47624801 NA -0.41 -7.16 -0.36 5.05e-12 Subjective well-being; LUSC cis rs4343996 0.701 rs13224926 chr7:3386594 C/T cg21248987 chr7:3385318 SDK1 -0.35 -5.91 -0.31 8.42e-9 Motion sickness; LUSC cis rs11122272 0.735 rs973253 chr1:231520874 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg06022373 chr22:39101656 GTPBP1 0.79 12.22 0.56 1.2e-28 Menopause (age at onset); LUSC cis rs1580019 0.961 rs766660 chr7:32499077 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.79 11.9 0.55 1.79e-27 Cognitive ability; LUSC trans rs2739330 0.761 rs5760176 chr22:24402321 A/G cg06437703 chr8:37914619 EIF4EBP1 0.67 11.66 0.54 1.39e-26 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9325144 0.560 rs10876005 chr12:39126149 C/G cg13010199 chr12:38710504 ALG10B -0.5 -7.96 -0.4 2.68e-14 Morning vs. evening chronotype; LUSC cis rs6087990 0.735 rs2889703 chr20:31379184 C/A cg13636640 chr20:31349939 DNMT3B 0.88 17.38 0.69 1.19e-48 Ulcerative colitis; LUSC cis rs7582720 0.943 rs115628302 chr2:203690047 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 7.98 0.4 2.35e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6076960 0.684 rs3909041 chr20:6249598 C/G cg17788362 chr6:86352627 SYNCRIP 0.44 6.29 0.33 9.71e-10 Smooth-surface caries; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg04234412 chr22:24373322 LOC391322 -0.85 -15.02 -0.63 2.49e-39 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7809950 0.637 rs2701685 chr7:107299584 A/G cg23024343 chr7:107201750 COG5 0.53 8.08 0.4 1.19e-14 Coronary artery disease; LUSC cis rs4478858 0.735 rs6676682 chr1:31809816 C/T cg00250761 chr1:31883323 NA -0.36 -8.91 -0.44 3.33e-17 Alcohol dependence; LUSC cis rs2227930 0.506 rs1485393 chr3:142052616 A/G cg16271453 chr3:142027066 XRN1 -0.55 -9.98 -0.48 1.06e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs4938330 0.680 rs4938329 chr11:116928112 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.49 -6.24 -0.32 1.34e-9 Blood protein levels; LUSC cis rs1348850 0.519 rs10201883 chr2:178471407 T/C cg22681709 chr2:178499509 PDE11A -0.52 -7.04 -0.36 1.1e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg01879757 chr17:41196368 BRCA1 0.45 7.17 0.37 4.89e-12 Menopause (age at onset); LUSC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg22903657 chr4:1355424 KIAA1530 -0.37 -6.03 -0.31 4.37e-9 Longevity; LUSC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg12963246 chr6:28129442 ZNF389 0.52 7.18 0.37 4.53e-12 Depression; LUSC cis rs11608355 0.515 rs11609630 chr12:109918934 C/T cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs7712401 0.601 rs30026 chr5:122284568 T/C cg19077854 chr5:122220652 SNX24 0.44 9.86 0.47 2.76e-20 Mean platelet volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17474694 chr1:100315971 AGL -0.42 -6.4 -0.33 5.15e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4494114 0.967 rs7532880 chr1:39297734 T/C cg25970120 chr1:39325951 RRAGC -0.43 -6.6 -0.34 1.59e-10 Blood protein levels; LUSC cis rs738321 0.757 rs4821748 chr22:38541936 G/A cg25457927 chr22:38595422 NA -0.42 -8.01 -0.4 1.93e-14 Breast cancer; LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg02951883 chr7:2050386 MAD1L1 -0.62 -12.05 -0.55 5.11e-28 Bipolar disorder and schizophrenia; LUSC trans rs4927850 0.957 rs4927851 chr3:195751853 A/G cg21051086 chr3:73046214 PPP4R2 -0.52 -7.93 -0.4 3.23e-14 Pancreatic cancer; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg07325562 chr11:65150083 SLC25A45 0.49 6.92 0.35 2.38e-11 Cognitive function;Information processing speed; LUSC cis rs8067354 0.872 rs7224006 chr17:57896338 C/T cg02344993 chr17:57696989 CLTC -0.37 -5.65 -0.3 3.42e-8 Hemoglobin concentration; LUSC cis rs75804782 0.521 rs72993056 chr2:239404671 G/T cg18131467 chr2:239335373 ASB1 -0.68 -6.28 -0.33 1.03e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs2832077 0.689 rs2832052 chr21:30130073 G/C cg08807101 chr21:30365312 RNF160 -0.55 -7.39 -0.37 1.18e-12 Cognitive test performance; LUSC cis rs1572438 0.896 rs9405366 chr6:858296 A/C cg13447295 chr6:887704 NA -0.46 -6.26 -0.32 1.15e-9 Aging; LUSC cis rs12594515 1.000 rs12594515 chr15:45985071 C/G cg01629716 chr15:45996671 NA -0.39 -5.81 -0.3 1.48e-8 Waist circumference;Weight; LUSC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg14830002 chr1:247616686 OR2B11 0.52 7.44 0.38 8.47e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs11722228 0.508 rs3796825 chr4:10092879 T/A cg26043149 chr18:55253948 FECH 1.0 15.01 0.63 2.71e-39 Gout;Urate levels;Serum uric acid levels; LUSC cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs7089973 0.604 rs55759483 chr10:116573423 T/C cg25233709 chr10:116636983 FAM160B1 0.43 7.51 0.38 5.4e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs138544659 1 rs138544659 chr15:78900701 T/G cg18825076 chr15:78729989 IREB2 -0.51 -7.91 -0.4 3.77e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema distribution in smoking;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 8.41 0.42 1.25e-15 Menarche (age at onset); LUSC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg12310025 chr6:25882481 NA -0.57 -9.52 -0.46 3.61e-19 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs447735 0.587 rs11647958 chr16:89720909 A/T cg06640241 chr16:89574553 SPG7 0.39 5.7 0.3 2.7e-8 Hemoglobin concentration; LUSC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg08680598 chr22:49984980 NA -0.34 -6.25 -0.32 1.24e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6545883 0.895 rs2256617 chr2:61679924 A/G cg15711740 chr2:61764176 XPO1 -0.45 -6.79 -0.35 5.13e-11 Tuberculosis; LUSC cis rs950776 0.518 rs12906951 chr15:78825562 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs2267681 0.583 rs10253277 chr7:139525978 A/G cg14116596 chr7:139528673 TBXAS1 0.37 6.38 0.33 5.86e-10 Cervical cancer; LUSC cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs9303401 0.659 rs7210432 chr17:56668170 C/T cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs17102423 0.530 rs4902357 chr14:65542067 C/G cg11161011 chr14:65562177 MAX -0.7 -10.88 -0.51 8.62e-24 Obesity-related traits; LUSC cis rs10203711 0.705 rs4286234 chr2:239616695 G/C cg14580085 chr2:239553406 NA 0.42 6.92 0.35 2.31e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs478304 0.651 rs11532071 chr11:65500198 C/A cg05805236 chr11:65401703 PCNXL3 -0.57 -9.34 -0.46 1.38e-18 Acne (severe); LUSC cis rs7089973 0.604 rs12218498 chr10:116578489 T/C cg25233709 chr10:116636983 FAM160B1 0.39 6.75 0.35 6.65e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg08736216 chr1:53307985 ZYG11A -0.28 -5.74 -0.3 2.14e-8 Monocyte count; LUSC cis rs6541297 1.000 rs6686680 chr1:230280522 T/C cg20703242 chr1:230279135 GALNT2 0.57 8.7 0.43 1.55e-16 Coronary artery disease; LUSC cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg27446573 chr6:127587934 RNF146 0.91 15.15 0.64 7.89e-40 Breast cancer; LUSC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg10523679 chr1:76189770 ACADM 0.83 13.72 0.6 2.84e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9522267 0.535 rs9522299 chr13:112236013 C/A cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 2.99e-8 Hepatitis; LUSC cis rs7100689 0.646 rs1953972 chr10:82145666 A/G cg01528321 chr10:82214614 TSPAN14 0.89 13.59 0.6 8.81e-34 Post bronchodilator FEV1; LUSC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg13397359 chr6:42928475 GNMT 0.43 5.9 0.31 8.84e-9 Blood protein levels; LUSC cis rs477692 1.000 rs4750759 chr10:131436603 G/A cg11019008 chr10:131425282 MGMT -0.39 -5.81 -0.3 1.44e-8 Response to temozolomide; LUSC cis rs10887741 1.000 rs12761361 chr10:89427203 G/C cg24243914 chr10:89418206 PAPSS2 0.33 6.04 0.31 4.19e-9 Exercise (leisure time); LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.03 0.77 4.68e-67 Prudent dietary pattern; LUSC cis rs17540621 1.000 rs115086675 chr2:47232247 C/T cg23978866 chr2:47230407 TTC7A -0.97 -6.63 -0.34 1.38e-10 Response to statin therapy; LUSC cis rs1023500 0.551 rs133379 chr22:42468535 A/G cg04733989 chr22:42467013 NAGA 0.64 9.88 0.48 2.31e-20 Schizophrenia; LUSC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg17971929 chr21:40555470 PSMG1 -0.62 -10.05 -0.48 6.07e-21 Cognitive function; LUSC cis rs17401966 0.838 rs1013952 chr1:10319247 G/A cg19773385 chr1:10388646 KIF1B -0.51 -8.81 -0.43 6.93e-17 Hepatocellular carcinoma; LUSC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg15445000 chr17:37608096 MED1 -0.38 -6.55 -0.34 2.15e-10 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18099408 chr3:52552593 STAB1 -0.41 -7.15 -0.36 5.58e-12 Bipolar disorder; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg20295408 chr7:1910781 MAD1L1 -0.47 -6.88 -0.35 2.94e-11 Bipolar disorder and schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23376446 chr14:100752258 NA 0.45 6.04 0.31 4.19e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs765787 0.530 rs4775834 chr15:45537511 C/T cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18217172 chr6:139309321 REPS1 -0.44 -6.81 -0.35 4.44e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg24531977 chr5:56204891 C5orf35 -0.58 -8.6 -0.43 3.09e-16 Coronary artery disease; LUSC cis rs6964587 0.620 rs6967588 chr7:91643402 G/T cg17063962 chr7:91808500 NA 0.58 9.54 0.46 3.05e-19 Breast cancer; LUSC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg08859206 chr1:53392774 SCP2 -0.42 -6.8 -0.35 4.75e-11 Monocyte count; LUSC cis rs7394190 0.748 rs60632610 chr10:75415677 C/T cg07699608 chr10:75541558 CHCHD1 0.49 5.65 0.3 3.43e-8 Incident atrial fibrillation; LUSC trans rs7944735 0.517 rs1827503 chr11:48225115 G/T cg15704280 chr7:45808275 SEPT13 0.7 6.53 0.34 2.48e-10 Intraocular pressure; LUSC cis rs7267979 0.718 rs2983489 chr20:25244120 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.73 14.75 0.63 2.93e-38 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg07061783 chr6:25882402 NA -0.38 -5.86 -0.31 1.12e-8 Blood metabolite levels; LUSC cis rs8060686 0.623 rs7205935 chr16:68152157 A/G cg09835421 chr16:68378352 PRMT7 -0.44 -5.78 -0.3 1.69e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs295140 0.773 rs13007517 chr2:201129729 C/T cg04283868 chr2:201171347 SPATS2L 0.41 5.95 0.31 6.78e-9 QT interval; LUSC cis rs9296092 0.521 rs9461886 chr6:33526770 T/C cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9733 0.650 rs11204668 chr1:150543686 G/A cg13175981 chr1:150552382 MCL1 0.48 6.56 0.34 2.08e-10 Tonsillectomy; LUSC cis rs8114671 0.662 rs6088664 chr20:33551100 G/A cg07148914 chr20:33460835 GGT7 0.49 7.28 0.37 2.45e-12 Height; LUSC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.5 7.29 0.37 2.25e-12 Total body bone mineral density; LUSC cis rs2078087 0.522 rs3768594 chr1:183212171 G/T cg13843938 chr1:183241246 NMNAT2 0.38 6.15 0.32 2.22e-9 Obesity-related traits; LUSC cis rs965604 1.000 rs4887057 chr15:78760918 G/A cg18825076 chr15:78729989 IREB2 0.42 6.77 0.35 5.79e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs4820539 1.000 rs2267002 chr22:23456702 T/C cg21100191 chr22:23484243 RTDR1 0.92 15.75 0.65 3.49e-42 Bone mineral density; LUSC trans rs9951602 0.512 rs12455591 chr18:76656028 A/G cg02800362 chr5:177631904 HNRNPAB 0.87 12.86 0.58 5.05e-31 Obesity-related traits; LUSC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg19812747 chr11:111475976 SIK2 -0.55 -7.79 -0.39 8.47e-14 Primary sclerosing cholangitis; LUSC cis rs62432291 0.681 rs439126 chr6:159656632 T/C cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC cis rs6696846 0.515 rs12739846 chr1:205096895 T/C cg00857998 chr1:205179979 DSTYK 0.46 6.55 0.34 2.2e-10 Red blood cell count; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg18538332 chr22:24372958 LOC391322 0.43 6.49 0.33 3.16e-10 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs4851254 0.660 rs56037757 chr2:100690130 A/G cg07810366 chr2:100720526 AFF3 -0.46 -6.16 -0.32 2.05e-9 Intelligence (multi-trait analysis); LUSC cis rs116988415 0.584 rs74859785 chr14:65249684 C/T cg25083366 chr14:65239357 SPTB 0.63 6.74 0.35 6.9e-11 Daytime sleep phenotypes; LUSC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg12963246 chr6:28129442 ZNF389 0.48 6.73 0.35 7.46e-11 Depression; LUSC cis rs35146811 0.735 rs2528900 chr7:99805319 A/G cg19116668 chr7:99932089 PMS2L1 0.33 5.7 0.3 2.64e-8 Coronary artery disease; LUSC cis rs61931739 0.534 rs4001713 chr12:34154195 A/C cg06521331 chr12:34319734 NA 0.43 6.85 0.35 3.57e-11 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg04944784 chr2:26401820 FAM59B -0.7 -9.84 -0.47 3.15e-20 Gut microbiome composition (summer); LUSC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg11766577 chr21:47581405 C21orf56 -0.41 -5.85 -0.3 1.19e-8 Testicular germ cell tumor; LUSC cis rs701145 0.585 rs1727957 chr3:153870407 G/A cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs11039100 0.607 rs1032649 chr11:5782773 A/T cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16246410 chr2:157189316 NR4A2 -0.4 -6.02 -0.31 4.72e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg14403583 chr14:105418241 AHNAK2 -0.58 -9.64 -0.47 1.48e-19 Rheumatoid arthritis; LUSC cis rs12701220 0.572 rs7792825 chr7:1006573 T/C cg26769984 chr7:1090371 C7orf50 0.44 6.5 0.33 2.98e-10 Bronchopulmonary dysplasia; LUSC cis rs7605827 0.930 rs4668449 chr2:15530141 T/C cg19274914 chr2:15703543 NA 0.47 9.08 0.44 1e-17 Educational attainment (years of education); LUSC trans rs7824557 0.628 rs11994376 chr8:11202960 G/A cg08975724 chr8:8085496 FLJ10661 0.43 6.22 0.32 1.47e-9 Retinal vascular caliber; LUSC cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg21545522 chr1:205238299 TMCC2 0.52 9.87 0.48 2.58e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7945718 0.875 rs9888258 chr11:12782716 A/G cg25843174 chr11:12811716 TEAD1 0.32 7.26 0.37 2.68e-12 Educational attainment (years of education); LUSC cis rs7729723 0.539 rs6895528 chr5:137810944 A/C cg19169342 chr5:137827400 NA -0.27 -5.9 -0.31 9.01e-9 Amyotrophic lateral sclerosis (C9orf72 mutation interaction); LUSC cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs308447 0.516 rs6815982 chr4:123677472 C/T cg10495464 chr4:123653540 BBS12;LOC729338 -0.85 -11.63 -0.54 1.77e-26 Perceived unattractiveness to mosquitoes; LUSC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg22920501 chr2:26401640 FAM59B 0.7 9.46 0.46 5.87e-19 Gut microbiome composition (summer); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00097626 chr1:205782249 SLC41A1 -0.4 -6.06 -0.31 3.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7829975 0.774 rs35431455 chr8:8673736 T/C cg11608241 chr8:8085544 FLJ10661 0.4 5.75 0.3 2.03e-8 Mood instability; LUSC cis rs10886558 0.662 rs10886560 chr10:121759608 A/G cg02041677 chr10:121771263 NA 0.33 5.72 0.3 2.37e-8 Shingles; LUSC cis rs2074585 0.517 rs11635361 chr15:91081791 G/T cg10434728 chr15:90938212 IQGAP1 -0.37 -6.91 -0.35 2.41e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs12579753 0.869 rs17692407 chr12:82171369 G/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.97 -0.31 6.07e-9 Resting heart rate; LUSC cis rs6500395 1.000 rs4785247 chr16:48687732 A/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12545109 0.800 rs1348082 chr8:57415016 A/G cg09654669 chr8:57350985 NA -0.57 -7.92 -0.4 3.57e-14 Obesity-related traits; LUSC cis rs738322 0.574 rs28653361 chr22:38570700 C/A cg25457927 chr22:38595422 NA -0.36 -7.13 -0.36 6.36e-12 Cutaneous nevi; LUSC cis rs730566 1.000 rs4858819 chr3:48478088 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.36 -5.71 -0.3 2.56e-8 Prion diseases; LUSC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg07701084 chr6:150067640 NUP43 0.53 7.85 0.39 5.88e-14 Lung cancer; LUSC cis rs8014204 0.806 rs11159104 chr14:75293374 A/G cg06637938 chr14:75390232 RPS6KL1 0.65 11.0 0.52 3.23e-24 Caffeine consumption; LUSC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg13393036 chr8:95962371 TP53INP1 -0.44 -9.06 -0.44 1.15e-17 Type 2 diabetes; LUSC cis rs425277 0.958 rs7546523 chr1:2043792 G/A cg03732007 chr1:2071316 PRKCZ 0.47 7.51 0.38 5.29e-13 Height; LUSC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.4 -5.82 -0.3 1.38e-8 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs7772486 0.806 rs4075696 chr6:146250947 T/C cg05347473 chr6:146136440 FBXO30 -0.48 -8.2 -0.41 5.16e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs11676348 0.774 rs13397673 chr2:219047782 A/G cg06547715 chr2:218990976 CXCR2 0.3 5.9 0.31 8.8e-9 Ulcerative colitis; LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg10523679 chr1:76189770 ACADM -0.93 -20.0 -0.74 4.48e-59 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6545883 0.929 rs778140 chr2:61682976 C/T cg15711740 chr2:61764176 XPO1 -0.42 -6.38 -0.33 5.87e-10 Tuberculosis; LUSC cis rs6723226 0.638 rs6543657 chr2:32705085 T/C cg02381751 chr2:32503542 YIPF4 0.55 8.54 0.42 4.91e-16 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg01579765 chr21:45077557 HSF2BP -0.51 -10.92 -0.51 6.15e-24 Mean corpuscular volume; LUSC cis rs7107174 1.000 rs11601161 chr11:78073280 A/G cg02023728 chr11:77925099 USP35 0.49 7.02 0.36 1.24e-11 Testicular germ cell tumor; LUSC trans rs62458065 0.850 rs7785999 chr7:32461262 G/T cg00845942 chr12:64062724 DPY19L2 -0.52 -6.09 -0.32 3.02e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg12823233 chr7:2316876 SNX8 -0.45 -7.76 -0.39 1.01e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs2786098 0.656 rs10922257 chr1:197545720 G/A cg16005942 chr6:160526640 IGF2R 0.51 6.09 0.32 3.12e-9 Asthma; LUSC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg18225595 chr11:63971243 STIP1 0.51 6.31 0.33 8.81e-10 Mean platelet volume; LUSC cis rs11711311 1.000 rs3773682 chr3:113520576 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.64 0.34 1.3e-10 IgG glycosylation; LUSC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg11062466 chr8:58055876 NA 0.67 7.68 0.39 1.81e-13 Developmental language disorder (linguistic errors); LUSC cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg06454157 chr6:167490870 NA -0.28 -6.58 -0.34 1.78e-10 Primary biliary cholangitis; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg17541715 chr7:1216824 NA -0.39 -6.23 -0.32 1.41e-9 Longevity;Endometriosis; LUSC cis rs8072100 0.688 rs7221224 chr17:45419061 T/G cg08085267 chr17:45401833 C17orf57 0.53 7.53 0.38 4.89e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2839186 0.814 rs2276257 chr21:47711229 A/G cg12379764 chr21:47803548 PCNT -0.42 -5.82 -0.3 1.38e-8 Testicular germ cell tumor; LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg07395648 chr5:131743802 NA -0.39 -5.76 -0.3 1.95e-8 Breast cancer; LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg11645453 chr3:52864694 ITIH4 0.37 8.64 0.43 2.35e-16 Bipolar disorder; LUSC cis rs1044826 0.692 rs188421 chr3:139234066 A/C cg15131784 chr3:139108705 COPB2 -0.38 -6.18 -0.32 1.87e-9 Obesity-related traits; LUSC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg04248312 chr19:17393744 ANKLE1 -1.02 -17.01 -0.68 3.4e-47 Systemic lupus erythematosus; LUSC trans rs6600671 1.000 rs4844607 chr1:121184059 C/T cg00646200 chr1:148855367 NA -0.44 -6.91 -0.35 2.47e-11 Hip geometry; LUSC cis rs35079168 0.735 rs1887309 chr9:137308242 A/G cg24164254 chr9:137329341 RXRA 0.39 6.53 0.34 2.44e-10 Intelligence; LUSC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg00343986 chr7:65444356 GUSB -0.43 -6.44 -0.33 4.26e-10 Aortic root size; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg07677032 chr17:61819896 STRADA 0.53 8.47 0.42 7.74e-16 Prudent dietary pattern; LUSC cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg04369109 chr6:150039330 LATS1 -0.54 -7.99 -0.4 2.19e-14 Lung cancer; LUSC cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg11244672 chr19:19639970 YJEFN3 -0.6 -7.3 -0.37 2.13e-12 Bipolar disorder; LUSC cis rs400736 0.729 rs2493215 chr1:8007716 C/T cg25007680 chr1:8021821 PARK7 0.47 6.99 0.36 1.48e-11 Response to antidepressants and depression; LUSC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg22029157 chr1:209979665 IRF6 0.6 9.88 0.48 2.29e-20 Monobrow; LUSC cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.65 0.86 4.24e-99 Chronic sinus infection; LUSC trans rs6601327 0.613 rs4612345 chr8:9580001 A/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.58 -0.34 1.83e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs10484885 0.690 rs292236 chr6:90528422 A/G cg13799429 chr6:90582589 CASP8AP2 -0.91 -10.69 -0.5 3.82e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2346177 0.580 rs7565770 chr2:46683683 A/C cg02822958 chr2:46747628 ATP6V1E2 0.49 8.47 0.42 8.11e-16 HDL cholesterol; LUSC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg13770153 chr20:60521292 NA -0.64 -9.0 -0.44 1.7e-17 Body mass index; LUSC cis rs4478858 0.735 rs4531329 chr1:31817810 A/T cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg09975044 chr14:104007538 NA -0.36 -5.66 -0.3 3.21e-8 Intelligence (multi-trait analysis); LUSC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg07636037 chr3:49044803 WDR6 1.03 18.37 0.71 1.37e-52 Parkinson's disease; LUSC cis rs4363385 0.740 rs1697428 chr1:153015761 C/A cg25856811 chr1:152973957 SPRR3 -0.36 -5.99 -0.31 5.45e-9 Inflammatory skin disease; LUSC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg10909506 chr17:38081995 ORMDL3 0.33 5.78 0.3 1.68e-8 Self-reported allergy; LUSC cis rs950776 0.518 rs12594391 chr15:78816240 A/G cg22563815 chr15:78856949 CHRNA5 0.26 6.31 0.33 8.74e-10 Sudden cardiac arrest; LUSC cis rs6681460 0.649 rs4655494 chr1:67002876 G/A cg02459107 chr1:67143332 SGIP1 0.37 6.18 0.32 1.92e-9 Presence of antiphospholipid antibodies; LUSC cis rs868036 0.681 rs9920643 chr15:68104314 C/T cg05925327 chr15:68127851 NA -0.4 -6.4 -0.33 5.35e-10 Restless legs syndrome; LUSC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg14668632 chr7:2872130 GNA12 -0.48 -7.11 -0.36 7.27e-12 Height; LUSC cis rs6845621 0.727 rs34295055 chr4:18909184 C/A cg12196642 chr4:18937545 NA -0.33 -6.27 -0.32 1.1e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs3733585 0.638 rs13145554 chr4:9979589 C/T cg26043149 chr18:55253948 FECH 0.47 7.22 0.37 3.56e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7107174 0.892 rs2510038 chr11:77966034 C/T cg02023728 chr11:77925099 USP35 0.45 6.3 0.33 9.6e-10 Testicular germ cell tumor; LUSC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg06219351 chr7:158114137 PTPRN2 -0.52 -9.51 -0.46 3.88e-19 Calcium levels; LUSC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.47 0.42 7.84e-16 Tonsillectomy; LUSC cis rs10504073 0.647 rs2292399 chr8:49987230 A/G cg00325661 chr8:49890786 NA 0.62 9.93 0.48 1.51e-20 Blood metabolite ratios; LUSC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg03806693 chr22:41940476 POLR3H -1.05 -15.17 -0.64 6.42e-40 Vitiligo; LUSC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg22875332 chr1:76189707 ACADM 0.83 14.28 0.62 1.86e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg03709012 chr19:19516395 GATAD2A 0.76 11.7 0.54 1e-26 Tonsillectomy; LUSC trans rs9929218 0.529 rs11640736 chr16:68738324 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.01 21.19 0.76 8.89e-64 Colorectal cancer; LUSC trans rs8002861 0.902 rs1445557 chr13:44464827 C/T cg12856521 chr11:46389249 DGKZ 0.4 6.34 0.33 7.43e-10 Leprosy; LUSC cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg09035930 chr12:129282057 SLC15A4 0.74 16.34 0.67 1.65e-44 Systemic lupus erythematosus; LUSC cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg10621924 chr7:39171070 POU6F2 0.42 6.24 0.32 1.35e-9 IgG glycosylation; LUSC cis rs754466 0.651 rs11815015 chr10:79625482 C/T cg17075019 chr10:79541650 NA -0.76 -12.26 -0.56 8.47e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg19717773 chr7:2847554 GNA12 -0.38 -5.88 -0.31 1.01e-8 Height; LUSC cis rs12421382 0.593 rs2118973 chr11:109389231 G/A cg16359550 chr11:109292809 C11orf87 0.34 5.99 0.31 5.43e-9 Schizophrenia; LUSC trans rs12692738 0.526 rs422265 chr2:165630796 C/T cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg12560992 chr17:57184187 TRIM37 0.81 15.09 0.64 1.3e-39 Intelligence (multi-trait analysis); LUSC cis rs3768617 0.510 rs2333620 chr1:183100555 T/C ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC cis rs3740713 1.000 rs76599129 chr11:18471627 T/A cg15463284 chr11:18477534 LDHAL6A -0.5 -5.72 -0.3 2.37e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg17252645 chr8:143867129 LY6D 0.37 6.61 0.34 1.55e-10 Urinary tract infection frequency; LUSC cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.88 -0.54 2.18e-27 Chronic sinus infection; LUSC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.57 0.38 3.73e-13 Parkinson's disease; LUSC cis rs2273669 0.667 rs16822 chr6:109307710 G/A cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs12900413 0.562 rs11631438 chr15:90300620 C/T cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9921222 0.500 rs11648673 chr16:377794 G/A cg09955084 chr16:413813 NA 0.26 5.72 0.3 2.35e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs1003719 0.715 rs2156077 chr21:38539357 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.57 -0.5 1.02e-22 Eye color traits; LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg08742575 chr21:47604166 C21orf56 0.46 7.01 0.36 1.3e-11 Testicular germ cell tumor; LUSC cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg11266682 chr4:10021025 SLC2A9 0.56 10.49 0.5 1.91e-22 Bone mineral density; LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg03579872 chr1:53393473 SCP2 0.39 5.67 0.3 3.15e-8 Monocyte count; LUSC cis rs8072100 0.811 rs1912483 chr17:45443494 A/G cg08085267 chr17:45401833 C17orf57 -0.55 -8.55 -0.42 4.52e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg21724239 chr8:58056113 NA 0.8 8.59 0.43 3.29e-16 Developmental language disorder (linguistic errors); LUSC cis rs34779708 0.733 rs61449529 chr10:35543914 T/C cg03585969 chr10:35415529 CREM 0.56 7.79 0.39 8.66e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3741151 0.773 rs58334887 chr11:73171510 A/C cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06022373 chr22:39101656 GTPBP1 0.76 12.2 0.56 1.44e-28 Menopause (age at onset); LUSC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg16989086 chr20:62203971 PRIC285 0.47 6.54 0.34 2.27e-10 Glioblastoma; LUSC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg10560079 chr2:191398806 TMEM194B 0.45 7.3 0.37 2.14e-12 Pulse pressure; LUSC cis rs12145833 0.538 rs10926977 chr1:243411367 T/G cg02356786 chr1:243265016 LOC731275 0.67 5.99 0.31 5.57e-9 Obesity (early onset extreme); LUSC cis rs614226 0.872 rs12307148 chr12:120903179 T/C cg27489772 chr12:121021490 NA -0.6 -7.72 -0.39 1.32e-13 Type 1 diabetes nephropathy; LUSC cis rs7923609 0.967 rs3999089 chr10:65203808 C/T cg01631684 chr10:65280961 REEP3 0.41 6.32 0.33 8.39e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs11048434 0.723 rs2080117 chr12:9138341 C/T cg23795048 chr12:9217529 LOC144571 0.33 5.79 0.3 1.62e-8 Sjögren's syndrome; LUSC cis rs2985684 1.000 rs1957977 chr14:50090603 A/G cg04989706 chr14:50066350 PPIL5 -0.44 -5.77 -0.3 1.79e-8 Carotid intima media thickness; LUSC cis rs75804782 0.690 rs56198112 chr2:239348887 A/G cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.65 0.43 2.17e-16 Alzheimer's disease; LUSC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg06238570 chr21:40685208 BRWD1 0.48 7.33 0.37 1.77e-12 Cognitive function; LUSC cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs4144743 0.528 rs12940207 chr17:45352194 G/T cg18085866 chr17:45331354 ITGB3 -0.74 -6.45 -0.33 3.89e-10 Body mass index; LUSC cis rs11229555 0.598 rs1893902 chr11:58190747 A/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2235649 0.663 rs12596160 chr16:1848784 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.46 -6.11 -0.32 2.76e-9 Blood metabolite levels; LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg08219700 chr8:58056026 NA 0.65 7.64 0.39 2.26e-13 Developmental language disorder (linguistic errors); LUSC cis rs7824557 0.564 rs2572395 chr8:11235360 A/C cg21775007 chr8:11205619 TDH -0.65 -10.27 -0.49 1.07e-21 Retinal vascular caliber; LUSC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg12963246 chr6:28129442 ZNF389 0.49 6.73 0.35 7.47e-11 Depression; LUSC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg12412775 chr1:25698385 RHCE -0.29 -5.93 -0.31 7.5e-9 Erythrocyte sedimentation rate; LUSC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg20503657 chr10:835505 NA 1.21 16.49 0.67 4.13e-45 Eosinophil percentage of granulocytes; LUSC cis rs2625529 0.668 rs8192386 chr15:72513148 A/C cg16672083 chr15:72433130 SENP8 0.49 7.36 0.37 1.45e-12 Red blood cell count; LUSC cis rs9837602 1.000 rs35521705 chr3:99716690 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.89 -0.31 9.26e-9 Breast cancer; LUSC cis rs9399135 0.935 rs4273704 chr6:135297520 G/T cg22676075 chr6:135203613 NA 0.47 7.33 0.37 1.72e-12 Red blood cell count; LUSC cis rs1371867 0.846 rs1660349 chr8:101319326 G/A cg06002616 chr8:101225028 SPAG1 -0.46 -7.58 -0.38 3.44e-13 Atrioventricular conduction; LUSC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg09365446 chr1:150670422 GOLPH3L 0.54 8.35 0.42 1.9e-15 Tonsillectomy; LUSC cis rs2242116 0.796 rs4587 chr3:46963502 T/C cg02527881 chr3:46936655 PTH1R -0.67 -12.22 -0.56 1.24e-28 Birth weight; LUSC cis rs3847687 1.000 rs3847687 chr12:131525053 C/T cg13586425 chr12:131519906 GPR133 -0.26 -5.92 -0.31 7.84e-9 Longevity; LUSC cis rs9322817 0.617 rs9391242 chr6:105231257 G/A cg02098413 chr6:105308735 HACE1 -0.27 -5.65 -0.3 3.39e-8 Thyroid stimulating hormone; LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg11062466 chr8:58055876 NA 0.58 8.24 0.41 3.97e-15 Developmental language disorder (linguistic errors); LUSC cis rs9611519 0.929 rs926914 chr22:41418154 C/T cg03806693 chr22:41940476 POLR3H -0.55 -7.46 -0.38 7.69e-13 Neuroticism; LUSC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.77 -0.39 9.79e-14 Reticulocyte count; LUSC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 6.61 0.34 1.52e-10 Personality dimensions; LUSC trans rs34546498 1 rs34546498 chr6:26961280 C/T cg06606381 chr12:133084897 FBRSL1 -1.0 -8.49 -0.42 7e-16 Breast cancer; LUSC cis rs11098499 0.863 rs1155576 chr4:120450159 A/C cg09307838 chr4:120376055 NA 0.73 10.31 0.49 7.81e-22 Corneal astigmatism; LUSC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08722720 chr15:34331557 AVEN;CHRM5 0.47 6.58 0.34 1.86e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs7819412 0.521 rs2409720 chr8:11037903 A/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.39 -0.37 1.15e-12 Triglycerides; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21432158 chr12:104530941 NFYB 0.39 6.06 0.31 3.7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg05347473 chr6:146136440 FBXO30 0.41 6.84 0.35 3.78e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs877282 0.853 rs11595510 chr10:756757 C/G cg13042288 chr15:90349979 ANPEP -0.46 -6.57 -0.34 1.89e-10 Uric acid levels; LUSC cis rs710216 0.917 rs3754223 chr1:43419091 A/T cg22176566 chr1:43424700 SLC2A1 0.43 6.06 0.31 3.7e-9 Red cell distribution width; LUSC cis rs12410462 0.581 rs7541809 chr1:227547299 G/A cg04117972 chr1:227635322 NA 0.62 6.74 0.35 7.04e-11 Major depressive disorder; LUSC cis rs8062405 1.000 rs62036624 chr16:28839930 G/T cg09754948 chr16:28834200 ATXN2L 0.43 6.35 0.33 7.17e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg11843238 chr5:131593191 PDLIM4 -0.4 -6.54 -0.34 2.32e-10 Blood metabolite levels; LUSC cis rs9039 0.513 rs9937906 chr16:9203871 A/G cg08831531 chr16:9218945 NA -0.45 -7.28 -0.37 2.47e-12 Menopause (age at onset); LUSC cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg04450456 chr4:17643702 FAM184B 0.35 5.8 0.3 1.56e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs57920188 0.585 rs12126679 chr1:4072921 C/T cg20703997 chr1:4087676 NA 0.6 8.35 0.42 1.8e-15 Interleukin-17 levels; LUSC cis rs897984 0.762 rs7206511 chr16:30950352 G/A cg02466173 chr16:30829666 NA 0.57 11.46 0.53 7.28e-26 Dementia with Lewy bodies; LUSC trans rs11039798 1.000 rs10160423 chr11:48457227 G/T cg15704280 chr7:45808275 SEPT13 0.66 6.02 0.31 4.48e-9 Axial length; LUSC trans rs1005277 0.522 rs1208681 chr10:38092975 C/T cg17830980 chr10:43048298 ZNF37B -0.41 -6.68 -0.34 1.01e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9649213 0.574 rs17436977 chr7:97883459 T/C cg24562669 chr7:97807699 LMTK2 0.38 6.45 0.33 3.95e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7615316 0.902 rs9820770 chr3:142175019 A/G cg16271453 chr3:142027066 XRN1 -0.41 -7.04 -0.36 1.07e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4595586 0.545 rs12823586 chr12:39391677 C/G cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs57920188 0.535 rs12129515 chr1:4094101 G/A cg20703997 chr1:4087676 NA 0.55 7.76 0.39 1.04e-13 Interleukin-17 levels; LUSC cis rs10838532 0.515 rs72904370 chr11:46040015 G/C cg24204282 chr11:45944920 GYLTL1B 0.44 5.85 0.3 1.17e-8 Axial length; LUSC cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg26384229 chr12:38710491 ALG10B -0.84 -14.53 -0.62 2.07e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg16405210 chr4:1374714 KIAA1530 0.52 7.92 0.4 3.48e-14 Obesity-related traits; LUSC cis rs72799341 1.000 rs72799341 chr16:30936743 G/A cg02466173 chr16:30829666 NA -0.51 -7.78 -0.39 8.92e-14 Diastolic blood pressure; LUSC cis rs2224391 0.540 rs1570085 chr6:5253063 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.5 -6.76 -0.35 6.08e-11 Height; LUSC trans rs9393777 0.920 rs13212562 chr6:27300310 A/G cg06606381 chr12:133084897 FBRSL1 -0.69 -6.99 -0.36 1.53e-11 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg23978390 chr7:1156363 C7orf50 0.43 6.28 0.32 1.06e-9 Longevity;Endometriosis; LUSC trans rs1728785 1.000 rs1094282 chr16:68577260 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.65 0.39 2.18e-13 Ulcerative colitis; LUSC trans rs1493916 0.807 rs10775455 chr18:31310761 A/C cg27147174 chr7:100797783 AP1S1 -0.53 -8.01 -0.4 1.91e-14 Life satisfaction; LUSC cis rs1443512 0.947 rs1822438 chr12:54342326 A/C cg17410650 chr12:54324560 NA -0.43 -6.77 -0.35 5.8200000000000003e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs2204008 0.744 rs11495519 chr12:38060546 C/A cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.25e-9 Bladder cancer; LUSC cis rs4631830 0.863 rs2611489 chr10:51524889 C/T cg20129853 chr10:51489980 NA -0.34 -7.0 -0.36 1.44e-11 Prostate-specific antigen levels; LUSC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg20243544 chr17:37824526 PNMT 0.47 6.01 0.31 4.83e-9 Glomerular filtration rate (creatinine); LUSC cis rs559928 0.606 rs55942618 chr11:63936005 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.25 0.37 2.93e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg18252515 chr7:66147081 NA -1.21 -13.94 -0.61 4.07e-35 Diabetic kidney disease; LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg26314531 chr2:26401878 FAM59B -0.67 -9.29 -0.45 1.99e-18 Gut microbiome composition (summer); LUSC cis rs11229555 0.609 rs11229451 chr11:58201687 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg09365446 chr1:150670422 GOLPH3L 0.49 7.17 0.37 4.8e-12 Melanoma; LUSC cis rs6424115 0.545 rs11576333 chr1:24065770 C/T cg10978503 chr1:24200527 CNR2 -0.44 -8.6 -0.43 3.05e-16 Immature fraction of reticulocytes; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg13395646 chr4:1353034 KIAA1530 0.59 9.04 0.44 1.32e-17 Obesity-related traits; LUSC cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.86 -0.54 2.57e-27 Chronic sinus infection; LUSC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg06212747 chr3:49208901 KLHDC8B 0.46 6.22 0.32 1.48e-9 Parkinson's disease; LUSC cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg12292205 chr6:26970375 C6orf41 -0.67 -9.09 -0.45 8.93e-18 Intelligence (multi-trait analysis); LUSC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg13114125 chr14:105738426 BRF1 0.91 15.46 0.65 5.01e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs57590327 0.503 rs9874464 chr3:81505488 C/G cg07356753 chr3:81810745 GBE1 -0.47 -6.19 -0.32 1.76e-9 Extraversion; LUSC cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg05283184 chr6:79620031 NA -0.57 -12.12 -0.55 2.96e-28 Intelligence (multi-trait analysis); LUSC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg12463550 chr7:65579703 CRCP -0.51 -7.49 -0.38 6.15e-13 Aortic root size; LUSC cis rs9462027 0.628 rs9469909 chr6:34813077 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.75 -0.3 1.97e-8 Systemic lupus erythematosus; LUSC cis rs117352156 0.943 rs10763675 chr10:29211930 A/G cg06394621 chr10:29236369 NA -0.47 -6.37 -0.33 6.16e-10 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.11e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1018697 1.000 rs7909612 chr10:104561456 G/A cg04362960 chr10:104952993 NT5C2 0.47 6.45 0.33 3.99e-10 Colorectal adenoma (advanced); LUSC cis rs1983170 0.808 rs4658230 chr1:92019325 T/C cg25838465 chr1:92012736 NA 0.42 5.91 0.31 8.39e-9 Eosinophil percentage of white cells; LUSC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg24578937 chr1:2090814 PRKCZ 0.45 10.22 0.49 1.64e-21 Height; LUSC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg15017067 chr4:17643749 FAM184B -0.36 -5.8 -0.3 1.51e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6541297 0.941 rs6665258 chr1:230279058 G/A cg05784532 chr1:230284198 GALNT2 0.49 7.39 0.38 1.16e-12 Coronary artery disease; LUSC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.73 -12.37 -0.56 3.47e-29 Total body bone mineral density; LUSC cis rs9399135 0.967 rs9376077 chr6:135299713 C/G cg22676075 chr6:135203613 NA 0.47 7.29 0.37 2.32e-12 Red blood cell count; LUSC cis rs7927592 0.913 rs10047412 chr11:68232912 T/C cg20283391 chr11:68216788 NA -0.62 -8.6 -0.43 3.23e-16 Total body bone mineral density; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg16031515 chr1:205743344 RAB7L1 -0.28 -5.98 -0.31 5.72e-9 Menarche (age at onset); LUSC cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.77 0.57 1.06e-30 Motion sickness; LUSC cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg08213375 chr14:104286397 PPP1R13B 0.52 10.25 0.49 1.29e-21 Schizophrenia; LUSC cis rs2230307 0.572 rs621212 chr1:100559281 T/C cg24955406 chr1:100503596 HIAT1 0.59 6.44 0.33 4.1e-10 Carotid intima media thickness; LUSC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg08499158 chr17:42289980 UBTF -0.37 -6.08 -0.32 3.2e-9 Total body bone mineral density; LUSC cis rs9513627 0.915 rs80270035 chr13:100121784 C/T cg25919922 chr13:100150906 NA -0.8 -6.96 -0.36 1.83e-11 Obesity-related traits; LUSC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg04398451 chr17:18023971 MYO15A -0.44 -7.13 -0.36 6.2e-12 Total body bone mineral density; LUSC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg10523679 chr1:76189770 ACADM -0.91 -14.62 -0.62 9.2e-38 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4285028 0.848 rs77630152 chr3:121681194 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.68 -0.47 1.07e-19 Multiple sclerosis; LUSC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg13010344 chr12:123464640 ARL6IP4 0.44 6.61 0.34 1.55e-10 Neutrophil percentage of white cells; LUSC cis rs3126085 0.877 rs12133847 chr1:152170101 T/G cg26876637 chr1:152193138 HRNR 0.47 6.69 0.34 9.42e-11 Atopic dermatitis; LUSC trans rs2840044 1.000 rs225277 chr17:33973311 G/A cg19694781 chr19:47549865 TMEM160 -0.57 -9.11 -0.45 7.65e-18 Response to radiotherapy in cancer (late toxicity); LUSC cis rs72781680 0.898 rs111460347 chr2:24018833 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC trans rs4332037 0.707 rs56070303 chr7:1891015 C/T cg10840412 chr1:235813424 GNG4 0.45 5.95 0.31 6.8e-9 Bipolar disorder; LUSC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg20503657 chr10:835505 NA 0.8 11.08 0.52 1.71e-24 Eosinophil percentage of granulocytes; LUSC cis rs7572733 0.534 rs700672 chr2:198691455 G/A cg00792783 chr2:198669748 PLCL1 0.43 5.7 0.3 2.66e-8 Dermatomyositis; LUSC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg06484146 chr7:12443880 VWDE -0.69 -7.35 -0.37 1.53e-12 Coronary artery disease; LUSC trans rs1325195 0.881 rs2486995 chr1:179098475 C/T cg11624085 chr17:8464688 MYH10 0.44 7.3 0.37 2.08e-12 IgE grass sensitization; LUSC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg19302996 chr17:73780495 UNK 0.54 8.18 0.41 6.21e-15 White matter hyperintensity burden; LUSC trans rs2204008 0.805 rs4882575 chr12:37940573 G/A cg06521331 chr12:34319734 NA 0.4 6.23 0.32 1.37e-9 Bladder cancer; LUSC trans rs6952808 0.792 rs2056481 chr7:1955435 A/G cg04565464 chr8:145669602 NFKBIL2 0.37 6.06 0.31 3.7e-9 Bipolar disorder and schizophrenia; LUSC cis rs4704187 0.687 rs6858969 chr5:74379281 T/C cg03227963 chr5:74354835 NA 0.32 6.76 0.35 6.08e-11 Response to amphetamines; LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg01125463 chr6:42946178 PEX6 -0.37 -6.03 -0.31 4.27e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4343996 0.934 rs4722655 chr7:3342895 C/A cg21248987 chr7:3385318 SDK1 0.39 6.67 0.34 1.09e-10 Motion sickness; LUSC cis rs4285028 0.948 rs7615571 chr3:121665950 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.77 -0.47 5.45e-20 Multiple sclerosis; LUSC cis rs4356932 0.967 rs6856958 chr4:76952356 T/G cg00809888 chr4:76862425 NAAA 0.35 5.77 0.3 1.78e-8 Blood protein levels; LUSC cis rs12594515 1.000 rs12911309 chr15:45985719 G/C cg01629716 chr15:45996671 NA 0.4 5.87 0.31 1.05e-8 Waist circumference;Weight; LUSC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg04369109 chr6:150039330 LATS1 -0.57 -8.34 -0.42 1.91e-15 Lung cancer; LUSC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg03433033 chr1:76189801 ACADM -0.73 -9.6 -0.47 1.93e-19 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs1994135 0.692 rs1579909 chr12:33694780 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.6 0.34 1.61e-10 Resting heart rate; LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg10802521 chr3:52805072 NEK4 -0.57 -8.96 -0.44 2.39e-17 Bipolar disorder; LUSC cis rs61931739 0.500 rs11053201 chr12:34453903 T/A cg06521331 chr12:34319734 NA -0.41 -6.33 -0.33 8.04e-10 Morning vs. evening chronotype; LUSC trans rs11039798 0.588 rs1814768 chr11:48987455 T/C cg03929089 chr4:120376271 NA 0.68 7.66 0.39 2.09e-13 Axial length; LUSC cis rs8114671 0.967 rs1415773 chr20:33765585 G/A cg24642439 chr20:33292090 TP53INP2 0.4 5.84 0.3 1.23e-8 Height; LUSC cis rs6918586 0.658 rs198825 chr6:26122502 A/G cg17691542 chr6:26056736 HIST1H1C 0.38 5.73 0.3 2.21e-8 Schizophrenia; LUSC cis rs1355223 0.573 rs1597961 chr11:34727114 A/T cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.13 -0.32 2.55e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg07701084 chr6:150067640 NUP43 0.58 9.04 0.44 1.33e-17 Lung cancer; LUSC cis rs9393777 0.623 rs3757150 chr6:26476782 T/A cg12292205 chr6:26970375 C6orf41 -0.63 -7.57 -0.38 3.72e-13 Intelligence (multi-trait analysis); LUSC cis rs60695258 0.550 rs4693800 chr4:87915620 C/G cg10685359 chr4:87814065 C4orf36 0.33 5.98 0.31 5.83e-9 Hematocrit; LUSC cis rs57502260 0.704 rs72936599 chr11:68320405 G/A cg20283391 chr11:68216788 NA -0.62 -5.83 -0.3 1.29e-8 Total body bone mineral density (age 45-60); LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg02506360 chr16:46963989 GPT2 0.37 5.95 0.31 6.7e-9 Educational attainment (years of education); LUSC cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg11608241 chr8:8085544 FLJ10661 0.41 6.07 0.32 3.55e-9 Mood instability; LUSC cis rs9325144 0.560 rs2013804 chr12:38631079 C/T cg13010199 chr12:38710504 ALG10B -0.54 -8.16 -0.41 6.81e-15 Morning vs. evening chronotype; LUSC cis rs11264799 0.520 rs1885561 chr1:157548669 T/A cg18268488 chr1:157545234 FCRL4 0.39 7.67 0.39 1.92e-13 IgA nephropathy; LUSC trans rs6952808 0.771 rs10275045 chr7:1920826 C/T cg04565464 chr8:145669602 NFKBIL2 0.36 6.05 0.31 3.98e-9 Bipolar disorder and schizophrenia; LUSC cis rs4704187 0.687 rs6896474 chr5:74453818 C/G cg03227963 chr5:74354835 NA -0.3 -5.77 -0.3 1.77e-8 Response to amphetamines; LUSC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.82 -0.63 1.57e-38 Total body bone mineral density; LUSC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg27211696 chr2:191398769 TMEM194B 0.61 11.67 0.54 1.29e-26 Pulse pressure; LUSC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg16325326 chr1:53192061 ZYG11B 0.81 14.0 0.61 2.39e-35 Monocyte count; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.07 0.32 3.48e-9 Lymphocyte counts; LUSC cis rs9419702 0.568 rs7093241 chr10:133556596 G/A cg04492858 chr10:133558786 NA 0.39 6.66 0.34 1.14e-10 Survival in rectal cancer; LUSC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg09835421 chr16:68378352 PRMT7 -0.52 -5.93 -0.31 7.45e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs500891 0.553 rs6941094 chr6:84138485 C/A cg08257003 chr6:84140564 ME1 0.37 9.17 0.45 5.06e-18 Platelet-derived growth factor BB levels; LUSC cis rs637571 0.565 rs633800 chr11:65638719 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.47 -8.4 -0.42 1.27e-15 Eosinophil percentage of white cells; LUSC cis rs7512552 0.839 rs1694385 chr1:150377960 G/A cg15654264 chr1:150340011 RPRD2 0.61 10.09 0.48 4.38e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC trans rs7726839 0.540 rs72705102 chr5:659437 T/C cg11887960 chr12:57824829 NA 0.52 6.54 0.34 2.29e-10 Obesity-related traits; LUSC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.14e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg04176532 chr22:50317003 CRELD2 -0.35 -5.68 -0.3 2.92e-8 Schizophrenia; LUSC cis rs7011049 1.000 rs6988927 chr8:53837496 T/C cg26025543 chr8:53854495 NA 0.52 6.17 0.32 1.95e-9 Systolic blood pressure; LUSC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg18876405 chr7:65276391 NA 0.56 8.82 0.43 6.35e-17 Aortic root size; LUSC cis rs7647973 0.593 rs28535523 chr3:49848414 C/T cg03060546 chr3:49711283 APEH -0.61 -7.17 -0.37 4.92e-12 Menarche (age at onset); LUSC cis rs7607369 0.718 rs6727147 chr2:219639024 G/A cg02176678 chr2:219576539 TTLL4 -0.55 -9.78 -0.47 4.92e-20 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.85 -0.44 5.02e-17 Axial length; LUSC cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.97 0.51 4.04e-24 Monocyte percentage of white cells; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg24675658 chr1:53192096 ZYG11B 0.79 13.29 0.59 1.24e-32 Monocyte count; LUSC cis rs4911259 0.507 rs8118663 chr20:31398876 A/G cg13636640 chr20:31349939 DNMT3B 0.66 9.42 0.46 7.73e-19 Inflammatory bowel disease; LUSC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg05872129 chr22:39784769 NA -0.59 -11.12 -0.52 1.21e-24 Intelligence (multi-trait analysis); LUSC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg24110177 chr3:50126178 RBM5 0.6 9.95 0.48 1.35e-20 Intelligence (multi-trait analysis); LUSC cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg15103426 chr22:29168792 CCDC117 0.46 5.94 0.31 7.06e-9 Lymphocyte counts; LUSC cis rs11792861 0.781 rs11789252 chr9:111762010 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.55 7.91 0.4 3.87e-14 Menarche (age at onset); LUSC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg12564285 chr5:131593104 PDLIM4 0.42 7.68 0.39 1.74e-13 Breast cancer; LUSC cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.42 -0.33 4.6e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg27086020 chr5:148206096 ADRB2 0.75 6.02 0.31 4.59e-9 Cognitive performance; LUSC cis rs7945705 0.875 rs11042059 chr11:8795080 G/A cg12365402 chr11:9010492 NRIP3 0.45 7.99 0.4 2.21e-14 Hemoglobin concentration; LUSC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.39e-11 Monocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24491766 chr7:21985706 CDCA7L -0.4 -5.95 -0.31 6.75e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs174449 0.603 rs174460 chr11:61657110 C/T cg01500311 chr11:61656094 FADS3 0.44 7.93 0.4 3.41e-14 Trans fatty acid levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg12748915 chr4:95373019 PDLIM5 0.4 6.33 0.33 7.81e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs9403521 1.000 rs9403521 chr6:143994199 C/T cg18240653 chr6:144019428 PHACTR2 0.51 6.2 0.32 1.65e-9 Obesity-related traits; LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg22963979 chr7:1858916 MAD1L1 -0.47 -6.9 -0.35 2.65e-11 Bipolar disorder and schizophrenia; LUSC cis rs9311676 0.632 rs11925533 chr3:58429908 G/A cg26110898 chr3:58419937 PDHB 0.41 6.69 0.34 9.7e-11 Systemic lupus erythematosus; LUSC cis rs7020830 0.858 rs13293465 chr9:37127678 C/T cg14294708 chr9:37120828 ZCCHC7 1.11 25.84 0.82 1.22e-81 Schizophrenia; LUSC cis rs59918340 0.523 rs4961255 chr8:142208248 T/C cg23750338 chr8:142222470 SLC45A4 0.45 8.26 0.41 3.5e-15 Immature fraction of reticulocytes; LUSC cis rs8113142 0.614 rs4805257 chr19:29130465 A/G cg04546413 chr19:29218101 NA -0.43 -6.1 -0.32 2.96e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs9837602 1.000 rs9873878 chr3:99711816 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.89 -0.31 9.26e-9 Breast cancer; LUSC cis rs1670533 1.000 rs633556 chr4:1092405 A/G cg16405210 chr4:1374714 KIAA1530 -0.46 -5.69 -0.3 2.85e-8 Recombination rate (females); LUSC trans rs877282 0.898 rs12354872 chr10:763362 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.97e-10 Uric acid levels; LUSC cis rs6429082 0.755 rs291370 chr1:235693041 A/G cg26050004 chr1:235667680 B3GALNT2 0.59 8.37 0.42 1.61e-15 Adiposity; LUSC cis rs2197308 0.740 rs1842595 chr12:37906223 G/A cg13010199 chr12:38710504 ALG10B -0.6 -9.33 -0.45 1.56e-18 Morning vs. evening chronotype; LUSC cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg06784218 chr1:46089804 CCDC17 -0.58 -11.51 -0.53 4.83e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7568458 1.000 rs7568458 chr2:85788175 T/A cg23752985 chr2:85803571 VAMP8 0.33 7.06 0.36 9.61e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6939532 0.522 rs4712980 chr6:26355758 G/T cg09904177 chr6:26538194 HMGN4 0.44 6.11 0.32 2.77e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.54 -8.13 -0.41 8.64e-15 Axial length; LUSC cis rs6840360 1.000 rs1105536 chr4:152605027 C/T cg22705602 chr4:152727874 NA -0.27 -5.74 -0.3 2.15e-8 Intelligence (multi-trait analysis); LUSC cis rs75804782 0.641 rs59499060 chr2:239341411 C/T cg18131467 chr2:239335373 ASB1 -0.72 -6.56 -0.34 2.07e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg20887711 chr4:1340912 KIAA1530 0.43 6.71 0.34 8.33e-11 Obesity-related traits; LUSC cis rs9790314 0.586 rs1839491 chr3:161126429 C/A cg03342759 chr3:160939853 NMD3 -0.44 -6.84 -0.35 3.76e-11 Morning vs. evening chronotype; LUSC cis rs34421088 0.506 rs2409755 chr8:11169983 G/A cg21293242 chr8:11204541 TDH 0.31 5.8 0.3 1.54e-8 Neuroticism; LUSC cis rs11605924 0.901 rs11607883 chr11:45839709 G/A ch.11.939596F chr11:45881766 CRY2 -0.48 -7.11 -0.36 6.9e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs9902453 0.817 rs2729449 chr17:28089751 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -9.36 -0.46 1.22e-18 Coffee consumption (cups per day); LUSC cis rs68092024 0.704 rs704575 chr3:99486075 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -6.14 -0.32 2.31e-9 Cleft lip with or without cleft palate; LUSC cis rs1385374 0.800 rs12321679 chr12:129284791 G/A cg09035930 chr12:129282057 SLC15A4 -0.64 -6.78 -0.35 5.5e-11 Systemic lupus erythematosus; LUSC cis rs9640161 0.659 rs7781827 chr7:150008858 T/C cg21361702 chr7:150065534 REPIN1 0.45 6.32 0.33 8.59e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg16339924 chr4:17578868 LAP3 0.51 7.58 0.38 3.42e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12413816 0.818 rs35567671 chr10:13769722 C/A cg16485048 chr10:13749193 FRMD4A 0.44 7.28 0.37 2.36e-12 Red cell distribution width; LUSC trans rs61931739 0.500 rs3924705 chr12:34557825 A/T cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg14414819 chr6:37225644 TMEM217;TBC1D22B 0.46 6.1 0.32 2.91e-9 Cognitive function;Information processing speed; LUSC cis rs829883 0.724 rs1439774 chr12:98907692 C/T cg25150519 chr12:98850993 NA -0.64 -8.7 -0.43 1.53e-16 Colorectal adenoma (advanced); LUSC cis rs16949788 1.000 rs7182169 chr15:66748213 C/A cg08120210 chr15:66682733 MAP2K1 -0.62 -6.2 -0.32 1.65e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7809950 0.648 rs114452520 chr7:107176780 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.77 -0.43 9.38e-17 Coronary artery disease; LUSC cis rs72792276 1.000 rs13357283 chr5:127423114 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.92 8.8 0.43 7.27e-17 Red cell distribution width; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg16145915 chr7:1198662 ZFAND2A -0.61 -11.51 -0.53 4.92e-26 Longevity;Endometriosis; LUSC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -6.77 -0.35 5.9e-11 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.83 0.63 1.46e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6426558 0.537 rs10495253 chr1:227471820 A/T cg10327440 chr1:227177885 CDC42BPA 0.54 7.2 0.37 3.97e-12 Neutrophil percentage of white cells; LUSC cis rs7918232 0.943 rs4747584 chr10:27373333 G/A cg14442939 chr10:27389572 ANKRD26 0.89 10.1 0.48 4.15e-21 Breast cancer; LUSC cis rs1371867 0.875 rs1125706 chr8:101326739 T/A cg06002616 chr8:101225028 SPAG1 -0.46 -7.49 -0.38 6.19e-13 Atrioventricular conduction; LUSC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.91 0.35 2.49e-11 Parkinson's disease; LUSC cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg22676075 chr6:135203613 NA -0.72 -12.5 -0.56 1.16e-29 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.43 0.78 1.26e-68 Prudent dietary pattern; LUSC trans rs2262909 0.962 rs4932952 chr19:22246788 G/A cg05197062 chr11:11642011 GALNTL4 0.56 7.88 0.4 4.75e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9457247 0.534 rs2757053 chr6:167380338 A/C cg23791538 chr6:167370224 RNASET2 0.5 8.37 0.42 1.65e-15 Crohn's disease; LUSC cis rs7937682 0.921 rs10789841 chr11:111469582 T/C cg19812747 chr11:111475976 SIK2 0.53 7.53 0.38 4.72e-13 Primary sclerosing cholangitis; LUSC cis rs887829 0.531 rs4338954 chr2:234593931 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.31 -0.33 8.87e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs1941687 0.732 rs3744888 chr18:31402594 A/G cg27147174 chr7:100797783 AP1S1 -0.43 -6.44 -0.33 4.21e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2734839 0.964 rs1107162 chr11:113289037 A/G cg14159747 chr11:113255604 NA -0.3 -7.55 -0.38 4.3e-13 Information processing speed; LUSC cis rs10986311 0.706 rs7851278 chr9:127102939 T/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.42 6.74 0.35 6.82e-11 Vitiligo; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.51 0.38 5.34e-13 Prudent dietary pattern; LUSC cis rs9796 0.870 rs4244584 chr15:41259523 A/G cg18705301 chr15:41695430 NDUFAF1 0.44 7.62 0.38 2.61e-13 Menopause (age at onset); LUSC cis rs4450131 0.569 rs3824801 chr10:126356840 T/G cg20435097 chr10:126320824 FAM53B 0.24 6.15 0.32 2.26e-9 White blood cell count (basophil); LUSC cis rs3087591 0.919 rs2018624 chr17:29560777 T/G cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.92 -0.4 3.46e-14 Hip circumference; LUSC cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.02 0.48 7.77e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs637571 0.522 rs528736 chr11:65705108 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.46 6.5 0.34 2.94e-10 Eosinophil percentage of white cells; LUSC cis rs73200209 0.744 rs61562746 chr12:116456445 A/C cg01776926 chr12:116560359 MED13L -0.51 -5.96 -0.31 6.56e-9 Total body bone mineral density; LUSC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg09021430 chr5:549028 NA -0.6 -9.39 -0.46 9.86e-19 Obesity-related traits; LUSC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg19622623 chr12:86230825 RASSF9 -0.41 -5.68 -0.3 2.86e-8 Major depressive disorder; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.18 -0.52 7.42e-25 Alzheimer's disease; LUSC trans rs3942852 0.524 rs7118665 chr11:48078427 C/A cg15704280 chr7:45808275 SEPT13 0.64 8.34 0.42 1.95e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs11252926 0.545 rs10466270 chr10:556129 A/G cg18196295 chr10:418757 DIP2C 0.38 6.17 0.32 1.93e-9 Psychosis in Alzheimer's disease; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg22907277 chr7:1156413 C7orf50 0.62 9.54 0.46 3.1e-19 Longevity;Endometriosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09852601 chr17:72732955 RAB37 -0.48 -6.45 -0.33 3.98e-10 Bipolar disorder and schizophrenia; LUSC cis rs57143961 1 rs57143961 chr19:16533225 C/CT cg10248733 chr19:16607483 C19orf44;CALR3 -0.55 -6.35 -0.33 6.89e-10 Lymphocyte percentage of white cells; LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg05340658 chr4:99064831 C4orf37 0.65 11.09 0.52 1.58e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg12677248 chr5:167913319 RARS 0.48 6.19 0.32 1.78e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg07741184 chr6:167504864 NA -0.36 -6.54 -0.34 2.36e-10 Crohn's disease; LUSC cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg13256891 chr4:100009986 ADH5 -0.43 -6.0 -0.31 5.06e-9 Alcohol dependence; LUSC cis rs4654899 0.743 rs61778528 chr1:21059837 C/T cg01072550 chr1:21505969 NA -0.48 -7.05 -0.36 1.05e-11 Superior frontal gyrus grey matter volume; LUSC cis rs240764 0.817 rs239211 chr6:101144965 A/C cg09795085 chr6:101329169 ASCC3 0.42 6.12 0.32 2.55e-9 Neuroticism; LUSC cis rs34172651 0.917 rs7204281 chr16:24784475 C/T cg00339695 chr16:24857497 SLC5A11 0.41 7.02 0.36 1.23e-11 Intelligence (multi-trait analysis); LUSC cis rs6456156 0.583 rs7748224 chr6:167456860 C/T cg07741184 chr6:167504864 NA 0.38 6.77 0.35 5.65e-11 Primary biliary cholangitis; LUSC trans rs11992162 0.591 rs4240678 chr8:11802426 C/T cg14343924 chr8:8086146 FLJ10661 -0.43 -6.07 -0.32 3.46e-9 Monocyte count; LUSC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg25566285 chr7:158114605 PTPRN2 0.31 5.85 0.3 1.2e-8 Calcium levels; LUSC trans rs60843830 0.550 rs300751 chr2:209063 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.41 6.55 0.34 2.18e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.84 -0.3 1.25e-8 Extrinsic epigenetic age acceleration; LUSC cis rs11711311 1.000 rs9828449 chr3:113518602 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.87 0.35 3.08e-11 IgG glycosylation; LUSC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg15147215 chr3:52552868 STAB1 -0.29 -5.76 -0.3 1.93e-8 Bipolar disorder; LUSC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.681 rs739236 chr22:50041602 A/G cg20744362 chr22:50050164 C22orf34 0.37 6.85 0.35 3.55e-11 Monocyte count;Monocyte percentage of white cells; LUSC trans rs3857536 0.740 rs9342532 chr6:66886297 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.22 -0.32 1.47e-9 Blood trace element (Cu levels); LUSC cis rs11098499 0.954 rs59866101 chr4:120296591 T/G cg24375607 chr4:120327624 NA 0.78 11.52 0.53 4.39e-26 Corneal astigmatism; LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.82 0.35 4.17e-11 Platelet count; LUSC trans rs2204008 0.837 rs12369089 chr12:38060263 G/A cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.25e-9 Bladder cancer; LUSC cis rs6987853 0.602 rs2974337 chr8:42390873 C/T cg09913449 chr8:42400586 C8orf40 0.45 7.57 0.38 3.68e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg20503657 chr10:835505 NA 1.23 15.71 0.65 4.86e-42 Eosinophil percentage of granulocytes; LUSC cis rs3106136 0.967 rs3106135 chr4:95138308 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.12 -0.32 2.68e-9 Capecitabine sensitivity; LUSC cis rs35264875 1.000 rs7110274 chr11:68842704 A/G cg02660097 chr11:68866761 NA 0.43 6.01 0.31 4.82e-9 Blond vs. brown hair color; LUSC cis rs11971779 0.715 rs55714903 chr7:139074590 T/C cg07862535 chr7:139043722 LUC7L2 0.59 7.37 0.37 1.32e-12 Diisocyanate-induced asthma; LUSC cis rs4908769 0.624 rs6678140 chr1:8436802 C/T cg00546117 chr1:8445545 RERE 0.29 5.93 0.31 7.74e-9 Allergy; LUSC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg09359103 chr1:154839909 KCNN3 -0.72 -17.43 -0.69 7.33e-49 Prostate cancer; LUSC cis rs6960043 0.818 rs2191349 chr7:15064309 G/T cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg02018176 chr4:1364513 KIAA1530 0.53 9.63 0.47 1.52e-19 Longevity; LUSC cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg05729581 chr11:3078854 CARS -0.53 -8.31 -0.41 2.35e-15 Longevity; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg27094323 chr7:1216898 NA -0.45 -7.81 -0.39 7.33e-14 Longevity;Endometriosis; LUSC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg13390004 chr1:15929781 NA 0.41 6.9 0.35 2.66e-11 Systolic blood pressure; LUSC cis rs7824557 0.767 rs10104728 chr8:11171300 A/G cg21293242 chr8:11204541 TDH 0.33 6.24 0.32 1.3e-9 Retinal vascular caliber; LUSC cis rs11779988 0.571 rs208053 chr8:17825327 G/A cg01800426 chr8:17659068 MTUS1 -0.49 -5.99 -0.31 5.46e-9 Breast cancer; LUSC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg07716408 chr11:68623521 NA -0.32 -6.36 -0.33 6.6e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10751667 0.666 rs7943140 chr11:973824 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.33e-10 Alzheimer's disease (late onset); LUSC cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg22676075 chr6:135203613 NA -0.61 -9.71 -0.47 8.64e-20 Red blood cell count; LUSC cis rs7098414 0.511 rs4934134 chr10:82160582 C/T cg01528321 chr10:82214614 TSPAN14 0.62 9.3 0.45 1.9e-18 Post bronchodilator FEV1; LUSC cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg22349387 chr12:9600060 DDX12 -0.43 -6.99 -0.36 1.49e-11 Breast size; LUSC cis rs10193935 0.901 rs6720837 chr2:42463173 A/T cg27598129 chr2:42591480 NA -0.56 -7.9 -0.4 3.97e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11649653 0.502 rs11864054 chr16:30846134 G/A cg02466173 chr16:30829666 NA -0.48 -9.34 -0.46 1.36e-18 Triglycerides; LUSC trans rs2055729 0.645 rs62489486 chr8:9741925 G/A cg06636001 chr8:8085503 FLJ10661 0.55 6.61 0.34 1.55e-10 Multiple myeloma (hyperdiploidy); LUSC trans rs9388451 0.772 rs1268064 chr6:126042578 G/A cg05039488 chr6:79577232 IRAK1BP1 0.56 8.88 0.44 4.22e-17 Brugada syndrome; LUSC trans rs11098499 0.954 rs11935596 chr4:120412457 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.58 0.34 1.81e-10 Corneal astigmatism; LUSC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg06028605 chr16:24865363 SLC5A11 0.7 11.23 0.52 4.73e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9902453 0.866 rs4795529 chr17:28443549 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 10.09 0.48 4.47e-21 Coffee consumption (cups per day); LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg03934478 chr11:495069 RNH1 0.83 10.05 0.48 6.3e-21 Body mass index; LUSC cis rs1577917 1.000 rs955197 chr6:86729675 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.1 -0.36 7.71e-12 Response to antipsychotic treatment; LUSC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg04414720 chr1:150670196 GOLPH3L 0.5 8.23 0.41 4.35e-15 Tonsillectomy; LUSC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg13057898 chr1:3703894 LRRC47 0.52 9.03 0.44 1.45e-17 Red cell distribution width; LUSC cis rs3099143 1.000 rs4541044 chr15:77173193 C/T cg21673338 chr15:77095150 SCAPER 0.81 7.7 0.39 1.56e-13 Recalcitrant atopic dermatitis; LUSC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg04398451 chr17:18023971 MYO15A -0.49 -7.9 -0.4 3.99e-14 Total body bone mineral density; LUSC trans rs7951105 1.000 rs12271653 chr11:39247083 T/C cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.83 0.39 6.66e-14 Colorectal cancer; LUSC cis rs11583043 0.708 rs12734559 chr1:101563001 G/A cg11406453 chr1:101602562 NA -0.4 -6.76 -0.35 6.13e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg15704280 chr7:45808275 SEPT13 -0.82 -10.42 -0.5 3.43e-22 Coronary artery disease; LUSC cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.8 -11.66 -0.54 1.32e-26 Chronic sinus infection; LUSC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg16928487 chr17:17741425 SREBF1 -0.43 -8.49 -0.42 6.87e-16 Total body bone mineral density; LUSC cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.05e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4132509 0.793 rs12037013 chr1:243784207 G/A cg21452805 chr1:244014465 NA 0.64 6.19 0.32 1.78e-9 RR interval (heart rate); LUSC cis rs8038465 0.638 rs12594175 chr15:73973186 C/T cg15420318 chr15:73925796 NPTN 0.59 10.06 0.48 5.73e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6061231 0.518 rs639836 chr20:60926223 G/A cg24112000 chr20:60950667 NA 0.38 7.22 0.37 3.49e-12 Colorectal cancer; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg13340481 chr17:27275985 PHF12 0.45 6.04 0.31 4.04e-9 Neuroticism; LUSC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.77 -13.47 -0.59 2.54e-33 Total body bone mineral density; LUSC cis rs870825 0.616 rs28444118 chr4:185621692 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs3087591 0.919 rs7406870 chr17:29590617 G/A cg24425628 chr17:29625626 OMG;NF1 0.65 9.24 0.45 3.06e-18 Hip circumference; LUSC cis rs12421382 0.636 rs60266280 chr11:109387766 A/C cg16359550 chr11:109292809 C11orf87 0.36 6.39 0.33 5.73e-10 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19682514 chr1:61549327 NFIA -0.39 -6.02 -0.31 4.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg21963583 chr11:68658836 MRPL21 0.56 8.34 0.42 1.94e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs61931739 0.649 rs815043 chr12:33722599 C/T cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg02428538 chr16:24856791 SLC5A11 0.5 5.72 0.3 2.32e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg06238570 chr21:40685208 BRWD1 0.6 10.12 0.48 3.5e-21 Cognitive function; LUSC cis rs6690583 0.623 rs55721024 chr1:85454447 A/C cg22153463 chr1:85462885 MCOLN2 0.62 6.0 0.31 5.12e-9 Serum sulfate level; LUSC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg12310025 chr6:25882481 NA 0.41 6.79 0.35 5.02e-11 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.03 -0.36 1.16e-11 Bipolar disorder; LUSC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg06636001 chr8:8085503 FLJ10661 0.71 11.94 0.55 1.35e-27 Mood instability; LUSC cis rs6546550 0.904 rs3771537 chr2:70038792 A/C cg02498382 chr2:70120550 SNRNP27 -0.28 -6.78 -0.35 5.51e-11 Prevalent atrial fibrillation; LUSC cis rs7208859 0.623 rs1054397 chr17:29110196 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6121246 0.865 rs6089055 chr20:30324045 C/T cg13852791 chr20:30311386 BCL2L1 0.97 12.49 0.56 1.27e-29 Mean corpuscular hemoglobin; LUSC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.35 -7.32 -0.37 1.86e-12 Schizophrenia; LUSC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.62 0.62 8.89e-38 Platelet count; LUSC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.97 -0.36 1.74e-11 Lung cancer; LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg19592336 chr6:28129416 ZNF389 -0.51 -6.81 -0.35 4.6e-11 Parkinson's disease; LUSC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.98 0.66 4.41e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.546 rs1456207 chr4:98676911 G/A cg17366294 chr4:99064904 C4orf37 0.53 8.27 0.41 3.15e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg20503657 chr10:835505 NA 0.63 7.93 0.4 3.38e-14 Eosinophil percentage of granulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22813821 chr12:72148853 RAB21 -0.41 -6.1 -0.32 2.9e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7312933 0.558 rs11181422 chr12:42718552 G/A cg01256987 chr12:42539512 GXYLT1 0.35 6.4 0.33 5.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg11905131 chr22:24372483 LOC391322 -0.5 -8.49 -0.42 6.76e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9395066 0.545 rs1831310 chr6:44976725 G/A cg25276700 chr6:44698697 NA 0.29 6.03 0.31 4.31e-9 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18722919 chr20:13619583 TASP1 0.71 5.98 0.31 5.64e-9 Cognitive performance; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg10729496 chr3:10149963 C3orf24 0.56 6.97 0.36 1.7e-11 Alzheimer's disease; LUSC cis rs12940923 0.810 rs7215408 chr17:56366106 T/G cg19466818 chr17:56409534 MIR142 -0.39 -6.86 -0.35 3.35e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs12617721 0.874 rs3754890 chr2:99088624 C/T cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs367943 0.673 rs7708084 chr5:112732692 G/T cg12552261 chr5:112820674 MCC 0.36 6.04 0.31 4.21e-9 Type 2 diabetes; LUSC cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg04586622 chr2:25135609 ADCY3 0.4 8.37 0.42 1.58e-15 Body mass index; LUSC cis rs7296418 0.961 rs10848428 chr12:123572495 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -7.2 -0.37 3.93e-12 Platelet count; LUSC trans rs61931739 0.500 rs11053260 chr12:34530215 T/G cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07328417 chr8:28558817 EXTL3 0.72 6.03 0.31 4.28e-9 Cognitive performance; LUSC cis rs1670533 0.872 rs13108222 chr4:1054256 C/A cg02018176 chr4:1364513 KIAA1530 0.44 6.08 0.32 3.24e-9 Recombination rate (females); LUSC cis rs909341 0.680 rs2427534 chr20:62366478 A/G cg09650180 chr20:62225654 GMEB2 -0.46 -5.98 -0.31 5.74e-9 Atopic dermatitis; LUSC cis rs10392 0.706 rs72623596 chr20:37585212 T/C cg27552599 chr20:37590471 DHX35 0.46 5.85 0.3 1.17e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs6598955 0.671 rs7417505 chr1:26575523 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg08439880 chr3:133502540 NA 0.35 6.26 0.32 1.17e-9 Iron status biomarkers; LUSC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg09034736 chr1:150693464 HORMAD1 0.42 5.8 0.3 1.55e-8 Melanoma; LUSC cis rs9393777 0.720 rs57713596 chr6:27004098 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.49 -6.17 -0.32 2e-9 Intelligence (multi-trait analysis); LUSC cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg05044414 chr3:183734942 ABCC5 0.19 6.37 0.33 6.44e-10 Anterior chamber depth; LUSC trans rs2262909 1.000 rs436039 chr19:22214873 T/C cg05197062 chr11:11642011 GALNTL4 -0.51 -7.08 -0.36 8.34e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4319547 0.695 rs4758666 chr12:122902840 C/T cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.16 -0.41 6.95e-15 Body mass index; LUSC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.48 0.62 3.21e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3847687 0.869 rs11061300 chr12:131523261 G/A cg13586425 chr12:131519906 GPR133 -0.26 -5.92 -0.31 7.9e-9 Longevity; LUSC cis rs9462027 0.628 rs3734264 chr6:34831866 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.68 -0.3 2.98e-8 Systemic lupus erythematosus; LUSC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg14440974 chr22:39074834 NA -0.35 -5.9 -0.31 8.75e-9 Menopause (age at onset); LUSC cis rs72781680 1.000 rs7578969 chr2:24168620 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg05585544 chr11:47624801 NA 0.42 7.3 0.37 2.17e-12 Subjective well-being; LUSC cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg16586182 chr3:47516702 SCAP -0.52 -8.11 -0.41 1e-14 Colorectal cancer; LUSC trans rs9650657 0.645 rs4841409 chr8:10516374 C/T cg15556689 chr8:8085844 FLJ10661 0.51 7.56 0.38 3.8e-13 Neuroticism; LUSC cis rs3862030 0.720 rs11593526 chr10:104228017 G/T cg22532475 chr10:104410764 TRIM8 0.25 5.93 0.31 7.44e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs780094 0.500 rs4666002 chr2:27840640 G/C cg27432699 chr2:27873401 GPN1 0.42 5.93 0.31 7.49e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg02951883 chr7:2050386 MAD1L1 -0.4 -6.98 -0.36 1.63e-11 Schizophrenia; LUSC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.48 0.33 3.2e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.23 -0.32 1.39e-9 Neutrophil percentage of white cells; LUSC cis rs7586879 0.752 rs11683748 chr2:25130434 C/T cg01884057 chr2:25150051 NA 0.42 8.82 0.43 6.26e-17 Body mass index; LUSC cis rs12478296 0.901 rs7603560 chr2:243043256 C/T cg06360820 chr2:242988706 NA -0.91 -9.85 -0.47 2.81e-20 Obesity-related traits; LUSC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg16325326 chr1:53192061 ZYG11B -0.99 -19.96 -0.74 6.94e-59 Monocyte count; LUSC cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg13010199 chr12:38710504 ALG10B -0.65 -10.25 -0.49 1.3e-21 Bladder cancer; LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg14343924 chr8:8086146 FLJ10661 0.44 6.24 0.32 1.34e-9 Neuroticism; LUSC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg07424592 chr7:64974309 NA 0.63 5.67 0.3 3.15e-8 Diabetic kidney disease; LUSC cis rs11579220 1 rs11579220 chr1:205144363 G/T cg03948781 chr1:205179583 DSTYK 0.31 5.94 0.31 7.05e-9 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs3768617 0.510 rs3768615 chr1:183103604 A/G ch.1.3577855R chr1:183094577 LAMC1 0.73 11.13 0.52 1.06e-24 Fuchs's corneal dystrophy; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg16218377 chr11:34073324 CAPRIN1 -0.51 -6.11 -0.32 2.81e-9 Height; LUSC cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs2679649 1.000 rs2684269 chr6:122354077 T/A cg00167820 chr8:131663355 NA 0.54 6.32 0.33 8.59e-10 Subcutaneous adipose tissue; LUSC cis rs9473147 0.543 rs1872505 chr6:47480975 C/G cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg26338869 chr17:61819248 STRADA 0.42 6.1 0.32 2.91e-9 Prudent dietary pattern; LUSC cis rs459571 1.000 rs2810489 chr9:136922700 C/T cg13789015 chr9:136890014 NCRNA00094 0.67 12.62 0.57 4.16e-30 Platelet distribution width; LUSC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg05425664 chr17:57184151 TRIM37 0.54 7.98 0.4 2.31e-14 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06080224 chr7:107204581 COG5;DUS4L -0.42 -5.95 -0.31 6.69e-9 Electrocardiographic conduction measures; LUSC cis rs7572733 0.534 rs10931794 chr2:198776140 C/T cg00792783 chr2:198669748 PLCL1 -0.45 -6.03 -0.31 4.46e-9 Dermatomyositis; LUSC cis rs12210905 0.622 rs116198502 chr6:26915015 A/G cg23155468 chr6:27110703 HIST1H2BK -0.67 -5.85 -0.3 1.18e-8 Hip circumference adjusted for BMI; LUSC cis rs7223966 1.000 rs7223966 chr17:61893398 G/A cg00945038 chr17:61921165 SMARCD2 0.38 5.76 0.3 1.95e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg08975724 chr8:8085496 FLJ10661 -0.47 -7.51 -0.38 5.43e-13 Mood instability; LUSC cis rs936229 0.813 rs1350193 chr15:75084281 G/C cg14664628 chr15:75095509 CSK -1.02 -17.47 -0.69 5.21e-49 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs11051970 0.918 rs7309706 chr12:32538208 A/T cg02745156 chr12:32552066 NA 0.44 6.93 0.35 2.24e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6754311 0.593 rs313518 chr2:136439090 C/T cg07169764 chr2:136633963 MCM6 0.55 7.29 0.37 2.32e-12 Mosquito bite size; LUSC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.69 0.3 2.74e-8 Personality dimensions; LUSC cis rs1160297 0.576 rs13002328 chr2:53085447 A/C cg07782112 chr2:53107842 NA 0.39 6.36 0.33 6.73e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg05425664 chr17:57184151 TRIM37 -0.53 -7.98 -0.4 2.33e-14 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7709377 0.620 rs11960815 chr5:115500207 A/C cg23108291 chr5:115420582 COMMD10 0.42 6.02 0.31 4.61e-9 Metabolite levels (X-11787); LUSC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg18404041 chr3:52824283 ITIH1 0.4 7.12 0.36 6.55e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9814567 1.000 rs4974484 chr3:134219019 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.01 -0.61 2.17e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg16405210 chr4:1374714 KIAA1530 -0.56 -8.61 -0.43 2.9e-16 Obesity-related traits; LUSC trans rs11039798 1.000 rs7102865 chr11:48458361 A/C cg15704280 chr7:45808275 SEPT13 0.66 6.02 0.31 4.48e-9 Axial length; LUSC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg00745463 chr17:30367425 LRRC37B -0.64 -7.81 -0.39 7.55e-14 Hip circumference adjusted for BMI; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg26338869 chr17:61819248 STRADA 0.43 6.17 0.32 1.92e-9 Prudent dietary pattern; LUSC cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.27 -0.37 2.56e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 7.05 0.36 1.06e-11 Intelligence (multi-trait analysis); LUSC cis rs2295359 1.000 rs12043240 chr1:67624304 C/T cg12940439 chr1:67600707 NA 0.36 6.16 0.32 2.08e-9 Psoriasis; LUSC cis rs6060717 0.654 rs6058347 chr20:34483781 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.5 -0.34 2.86e-10 Hip circumference adjusted for BMI; LUSC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg14883916 chr11:6947541 ZNF215 0.46 5.96 0.31 6.39e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg22907277 chr7:1156413 C7orf50 0.72 10.06 0.48 5.71e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs308403 0.509 rs9990804 chr4:123671984 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.94 17.0 0.68 4.05e-47 Blood protein levels; LUSC cis rs12893668 0.637 rs12892038 chr14:104068629 G/A cg08213375 chr14:104286397 PPP1R13B 0.4 6.92 0.35 2.33e-11 Reticulocyte count; LUSC cis rs899997 1.000 rs4887078 chr15:79011073 C/T cg04896959 chr15:78267971 NA 0.51 10.75 0.51 2.33e-23 Coronary artery disease or large artery stroke; LUSC cis rs694739 0.734 rs663743 chr11:64107735 G/A cg26898376 chr11:64110657 CCDC88B 0.33 5.93 0.31 7.68e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg20503657 chr10:835505 NA 1.0 13.97 0.61 3.14e-35 Eosinophil percentage of granulocytes; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg22166914 chr1:53195759 ZYG11B 0.62 9.94 0.48 1.47e-20 Monocyte count; LUSC cis rs7605827 0.930 rs4668905 chr2:15543776 C/A cg19274914 chr2:15703543 NA 0.47 9.08 0.44 9.67e-18 Educational attainment (years of education); LUSC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg04871131 chr7:94954202 PON1 -0.38 -6.08 -0.32 3.2e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg25019033 chr10:957182 NA -0.51 -6.35 -0.33 6.96e-10 Eosinophil percentage of granulocytes; LUSC cis rs427394 0.735 rs416689 chr5:6740855 C/T cg10857441 chr5:6722123 POLS -0.47 -9.15 -0.45 5.67e-18 Menopause (age at onset); LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg24503407 chr1:205819492 PM20D1 0.93 17.97 0.7 5.5e-51 Menarche (age at onset); LUSC cis rs3087591 0.708 rs2525569 chr17:29675971 T/A cg24425628 chr17:29625626 OMG;NF1 0.47 7.0 0.36 1.44e-11 Hip circumference; LUSC cis rs2404602 0.647 rs11637096 chr15:76931102 T/C cg23625390 chr15:77176239 SCAPER -0.63 -9.46 -0.46 5.78e-19 Blood metabolite levels; LUSC cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg06784218 chr1:46089804 CCDC17 0.48 9.34 0.46 1.39e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs921968 0.565 rs7603709 chr2:219642601 C/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.56 -0.46 2.72e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg12419862 chr22:24373484 LOC391322 -0.86 -13.97 -0.61 2.91e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg04545296 chr12:48745243 ZNF641 0.37 6.72 0.35 7.87e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs2243480 1.000 rs6966322 chr7:65646754 A/G cg10756647 chr7:56101905 PSPH -0.84 -8.42 -0.42 1.14e-15 Diabetic kidney disease; LUSC cis rs1395 1.000 rs1659685 chr2:27420690 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.39 -6.47 -0.33 3.47e-10 Blood metabolite levels; LUSC cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg03146154 chr1:46216737 IPP 0.54 7.73 0.39 1.27e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6484504 0.576 rs208103 chr11:31167400 A/G cg06552810 chr11:31128660 NA -0.38 -6.84 -0.35 3.71e-11 Red blood cell count; LUSC cis rs7592578 0.771 rs4439990 chr2:191398353 A/C cg10560079 chr2:191398806 TMEM194B -0.73 -8.95 -0.44 2.43e-17 Diastolic blood pressure; LUSC cis rs7572644 0.766 rs12614744 chr2:28269702 T/A cg27432699 chr2:27873401 GPN1 0.53 6.59 0.34 1.68e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9527 0.590 rs11191547 chr10:104843148 C/T cg05855489 chr10:104503620 C10orf26 0.54 8.21 0.41 5.02e-15 Arsenic metabolism; LUSC trans rs2727020 0.637 rs1164673 chr11:49328356 C/G cg15704280 chr7:45808275 SEPT13 0.6 8.82 0.43 6.42e-17 Coronary artery disease; LUSC trans rs11039798 1.000 rs12225599 chr11:48755868 T/C cg03929089 chr4:120376271 NA 0.74 6.91 0.35 2.4e-11 Axial length; LUSC cis rs908922 0.605 rs3753448 chr1:152486407 A/C cg20991723 chr1:152506922 NA 0.49 9.01 0.44 1.57e-17 Hair morphology; LUSC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg14004847 chr7:1930337 MAD1L1 -0.46 -6.94 -0.36 2.05e-11 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg02018176 chr4:1364513 KIAA1530 0.51 8.73 0.43 1.2e-16 Obesity-related traits; LUSC cis rs599083 0.573 rs3018713 chr11:68390986 A/G cg20283391 chr11:68216788 NA -0.56 -8.25 -0.41 3.82e-15 Bone mineral density (spine); LUSC cis rs9650315 0.866 rs34035722 chr8:57197333 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.13 0.36 6.25e-12 Height; LUSC cis rs4566357 0.615 rs12474622 chr2:227912793 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -8.27 -0.41 3.17e-15 Coronary artery disease; LUSC cis rs6598955 0.543 rs881578 chr1:26536141 G/A cg12744634 chr1:26560303 CCDC21 0.39 5.84 0.3 1.25e-8 Obesity-related traits; LUSC trans rs4811340 0.572 rs6068254 chr20:51180440 T/C cg15736553 chr3:11610338 VGLL4 -0.33 -5.95 -0.31 6.7e-9 Thyroid peroxidase antibody positivity; LUSC cis rs9341808 0.727 rs10943697 chr6:80931506 A/C cg08355045 chr6:80787529 NA 0.58 10.04 0.48 6.79e-21 Sitting height ratio; LUSC trans rs11992162 1.000 rs7460395 chr8:11835375 C/T cg06636001 chr8:8085503 FLJ10661 0.52 7.21 0.37 3.81e-12 Monocyte count; LUSC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg08847533 chr14:75593920 NEK9 0.86 16.04 0.66 2.53e-43 Height; LUSC cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.89 0.35 2.71e-11 Rheumatoid arthritis; LUSC cis rs7215564 0.818 rs34756632 chr17:78618859 C/T cg23238734 chr17:78661607 RPTOR 0.46 5.83 0.3 1.32e-8 Myopia (pathological); LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs134594 1.000 rs134601 chr22:29473495 G/T cg03665785 chr22:29458676 C22orf31 0.28 5.79 0.3 1.66e-8 Birth weight; LUSC cis rs929354 0.713 rs10085650 chr7:156993413 T/C cg05182265 chr7:156933206 UBE3C -0.6 -9.64 -0.47 1.48e-19 Body mass index; LUSC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg21285383 chr16:89894308 SPIRE2 0.34 7.25 0.37 2.89e-12 Vitiligo; LUSC cis rs6542838 0.641 rs12478574 chr2:99476369 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.37 -0.33 6.11e-10 Fear of minor pain; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg21583850 chr1:112532802 KCND3 0.44 6.36 0.33 6.69e-10 Mosquito bite size; LUSC cis rs7582180 0.676 rs10048665 chr2:100933085 A/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.36 -0.42 1.72e-15 Intelligence (multi-trait analysis); LUSC cis rs12681288 0.550 rs7000482 chr8:958380 T/C cg04851639 chr8:1020857 NA -0.35 -7.03 -0.36 1.19e-11 Schizophrenia; LUSC cis rs7568458 0.846 rs6705839 chr2:85761279 A/T cg17127132 chr2:85788382 GGCX 0.45 7.16 0.36 5.07e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs34891900 0.507 rs12167823 chr22:18124362 G/A cg08824373 chr22:18117835 NA -0.44 -6.74 -0.35 7.05e-11 Sum neutrophil eosinophil counts; LUSC cis rs13315871 0.929 rs2056120 chr3:58309436 A/T cg12435725 chr3:58293450 RPP14 -0.67 -6.78 -0.35 5.31e-11 Cholesterol, total; LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg11645453 chr3:52864694 ITIH4 0.36 8.68 0.43 1.79e-16 Bipolar disorder; LUSC trans rs11098499 0.731 rs9995026 chr4:120490499 T/A cg25214090 chr10:38739885 LOC399744 0.53 7.97 0.4 2.55e-14 Corneal astigmatism; LUSC cis rs7586879 1.000 rs12713419 chr2:25121853 G/A cg04586622 chr2:25135609 ADCY3 0.32 6.09 0.32 3.15e-9 Body mass index; LUSC cis rs6076065 0.723 rs2424530 chr20:23369354 A/G cg11657817 chr20:23433608 CST11 0.42 7.97 0.4 2.62e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.69 0.5 3.98e-23 Bladder cancer; LUSC cis rs6933660 0.610 rs71549125 chr6:151770796 A/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.84 -13.18 -0.58 3.11e-32 Menarche (age at onset); LUSC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg23172400 chr8:95962367 TP53INP1 0.37 6.78 0.35 5.5e-11 Type 2 diabetes; LUSC cis rs2730245 0.527 rs62475645 chr7:158656825 G/A cg24397884 chr7:158709396 WDR60 0.77 8.51 0.42 6.14e-16 Height; LUSC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg12560992 chr17:57184187 TRIM37 -0.88 -17.25 -0.69 3.97e-48 Intelligence (multi-trait analysis); LUSC cis rs7712401 0.580 rs383262 chr5:122345684 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.25 -0.45 2.68e-18 Mean platelet volume; LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.72e-10 Bipolar disorder; LUSC cis rs1577917 1.000 rs13194429 chr6:86646705 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs3092073 0.603 rs4810477 chr20:44544654 C/T cg23303369 chr20:44641161 MMP9 0.35 5.96 0.31 6.49e-9 Intelligence (multi-trait analysis); LUSC cis rs4808199 0.947 rs2163804 chr19:19575965 G/A cg03709012 chr19:19516395 GATAD2A 1.1 14.56 0.62 1.57e-37 Nonalcoholic fatty liver disease; LUSC cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 6.6 0.34 1.59e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4843747 0.671 rs4075599 chr16:88107423 C/G cg09044154 chr16:88155775 NA -0.57 -7.82 -0.39 6.89e-14 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21117768 chr2:85829779 TMEM150A -0.41 -6.2 -0.32 1.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11264799 0.539 rs12125930 chr1:157577086 A/G cg18268488 chr1:157545234 FCRL4 0.37 6.88 0.35 2.97e-11 IgA nephropathy; LUSC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -6.99 -0.36 1.55e-11 Major depressive disorder; LUSC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg12927641 chr6:109611667 NA -0.39 -6.76 -0.35 6.03e-11 Reticulocyte fraction of red cells; LUSC cis rs7945718 0.875 rs9888178 chr11:12782643 C/T cg25843174 chr11:12811716 TEAD1 0.32 7.3 0.37 2.16e-12 Educational attainment (years of education); LUSC cis rs4654899 0.644 rs6669077 chr1:21290520 A/C cg01072550 chr1:21505969 NA -0.53 -8.08 -0.4 1.23e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6601450 0.579 rs11775625 chr8:10272439 C/T cg21775007 chr8:11205619 TDH 0.41 5.89 0.31 9.29e-9 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg20243544 chr17:37824526 PNMT 0.39 5.84 0.3 1.26e-8 Self-reported allergy; LUSC cis rs11031096 0.727 rs2056853 chr11:4142172 C/T cg18678763 chr11:4115507 RRM1 -0.49 -7.27 -0.37 2.5e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs12681288 0.862 rs7015529 chr8:1020249 A/G cg15309053 chr8:964076 NA 0.33 6.58 0.34 1.84e-10 Schizophrenia; LUSC cis rs6429082 0.715 rs2172718 chr1:235580727 A/G cg26050004 chr1:235667680 B3GALNT2 -0.55 -7.83 -0.39 6.38e-14 Adiposity; LUSC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs10791097 0.694 rs3190331 chr11:130748131 C/T cg12179176 chr11:130786555 SNX19 -0.85 -15.01 -0.63 2.77e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs11250098 0.600 rs4240671 chr8:10767748 A/G cg06636001 chr8:8085503 FLJ10661 0.47 6.85 0.35 3.66e-11 Morning vs. evening chronotype; LUSC trans rs2739330 0.791 rs4822458 chr22:24265659 C/T cg06437703 chr8:37914619 EIF4EBP1 -0.51 -8.15 -0.41 7.16e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs877282 0.898 rs11253350 chr10:765968 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.41 -0.33 4.97e-10 Uric acid levels; LUSC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg13628971 chr7:2884303 GNA12 0.49 6.75 0.35 6.7e-11 Height; LUSC cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg06064525 chr11:970664 AP2A2 -0.48 -10.4 -0.49 3.79e-22 Alzheimer's disease (late onset); LUSC cis rs11626933 1.000 rs7146724 chr14:90766092 C/T cg14092571 chr14:90743983 NA -0.87 -18.47 -0.71 5.29e-53 Gut microbiota (bacterial taxa); LUSC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.09 -0.48 4.41e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg02018176 chr4:1364513 KIAA1530 0.45 7.71 0.39 1.45e-13 Obesity-related traits; LUSC cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg17507749 chr15:85114479 UBE2QP1 0.57 7.22 0.37 3.59e-12 Schizophrenia; LUSC cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg08999081 chr20:33150536 PIGU 0.37 6.57 0.34 1.92e-10 Height; LUSC cis rs17095355 1.000 rs12267704 chr10:111722008 C/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.49 -0.38 6.22e-13 Biliary atresia; LUSC cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg26898376 chr11:64110657 CCDC88B 0.35 6.82 0.35 4.37e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs3859192 0.599 rs2227321 chr17:38171294 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.54 0.57 8.07e-30 White blood cell count; LUSC cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 8.32 0.41 2.25e-15 Colorectal cancer; LUSC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg22963979 chr7:1858916 MAD1L1 -0.59 -9.01 -0.44 1.67e-17 Bipolar disorder and schizophrenia; LUSC cis rs9814567 0.896 rs2177602 chr3:134245866 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg09509183 chr1:209979624 IRF6 0.43 5.73 0.3 2.25e-8 Cleft lip with or without cleft palate; LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg14092988 chr3:52407081 DNAH1 0.3 5.81 0.3 1.46e-8 Bipolar disorder; LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg16606324 chr3:10149918 C3orf24 0.62 8.87 0.44 4.41e-17 Alzheimer's disease; LUSC cis rs10791097 0.629 rs11222361 chr11:130731424 T/G cg12179176 chr11:130786555 SNX19 0.76 12.34 0.56 4.43e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs5758511 0.773 rs62240999 chr22:42355563 C/G cg00645731 chr22:42541494 CYP2D7P1 0.45 7.31 0.37 1.95e-12 Birth weight; LUSC cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg05025164 chr4:1340916 KIAA1530 0.42 6.34 0.33 7.36e-10 Obesity-related traits; LUSC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg18099408 chr3:52552593 STAB1 0.35 5.67 0.3 3.16e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs12893668 0.644 rs12890820 chr14:104034849 T/C cg01849466 chr14:104193079 ZFYVE21 -0.47 -6.48 -0.33 3.28e-10 Reticulocyte count; LUSC cis rs2219968 0.743 rs7833315 chr8:78931987 T/C cg00738934 chr8:78996279 NA -0.42 -7.53 -0.38 4.74e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs12893668 0.703 rs8017993 chr14:104047734 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -6.58 -0.34 1.79e-10 Reticulocyte count; LUSC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.59 12.01 0.55 7.4e-28 Monocyte percentage of white cells; LUSC cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg01028140 chr2:1542097 TPO -0.49 -6.9 -0.35 2.56e-11 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7267979 0.780 rs6050679 chr20:25537827 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.77 16.08 0.66 1.68e-43 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg22681709 chr2:178499509 PDE11A 0.51 9.37 0.46 1.11e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs981844 1.000 rs72731672 chr4:154664925 G/T cg10279832 chr4:154682576 RNF175 -0.4 -5.77 -0.3 1.76e-8 Response to statins (LDL cholesterol change); LUSC cis rs4919087 1.000 rs10882898 chr10:99087330 G/A cg25902810 chr10:99078978 FRAT1 -0.46 -6.73 -0.35 7.24e-11 Monocyte count; LUSC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC trans rs11098499 0.954 rs11935596 chr4:120412457 G/C cg25214090 chr10:38739885 LOC399744 0.54 8.06 0.4 1.36e-14 Corneal astigmatism; LUSC cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.11e-14 Glomerular filtration rate (creatinine); LUSC cis rs7312933 0.510 rs1907705 chr12:42451122 T/A cg01256987 chr12:42539512 GXYLT1 -0.59 -12.43 -0.56 2.07e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1949733 1.000 rs2631745 chr4:8490530 T/C cg13073564 chr4:8508604 NA 0.47 9.16 0.45 5.17e-18 Response to antineoplastic agents; LUSC cis rs73198271 0.740 rs10094270 chr8:8646633 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.05 -0.31 3.91e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.27 -0.41 3.16e-15 Schizophrenia; LUSC cis rs2840044 1.000 rs7212704 chr17:33898897 C/T cg05299278 chr17:33885742 SLFN14 -0.31 -6.38 -0.33 5.88e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs4474465 0.850 rs4559714 chr11:78257302 C/T cg27205649 chr11:78285834 NARS2 0.52 6.2 0.32 1.7e-9 Alzheimer's disease (survival time); LUSC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg06544989 chr22:39130855 UNC84B 0.34 5.89 0.31 9.37e-9 Menopause (age at onset); LUSC cis rs11098499 0.863 rs36040693 chr4:120477616 A/G cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs1941023 0.584 rs6591578 chr11:60158649 G/A cg08716584 chr11:60157161 MS4A7 -0.62 -11.28 -0.53 3.11e-25 Congenital heart disease (maternal effect); LUSC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.4 -6.74 -0.35 6.87e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg02086790 chr16:375327 AXIN1 -0.34 -5.91 -0.31 8.24e-9 Bone mineral density (spine);Bone mineral density; LUSC trans rs1800594 1 rs1800594 chr1:169510524 A/G cg16792071 chr10:134842795 NA 0.29 5.95 0.31 6.75e-9 Ischemic stroke; LUSC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg14019146 chr3:50243930 SLC38A3 0.31 6.72 0.35 7.94e-11 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg18827107 chr12:86230957 RASSF9 -0.43 -6.4 -0.33 5.11e-10 Major depressive disorder; LUSC cis rs12928939 0.727 rs8053623 chr16:71647529 A/G cg03805757 chr16:71968109 PKD1L3 -0.4 -5.81 -0.3 1.47e-8 Post bronchodilator FEV1; LUSC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg18827107 chr12:86230957 RASSF9 -0.47 -6.99 -0.36 1.55e-11 Major depressive disorder; LUSC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg13393036 chr8:95962371 TP53INP1 -0.45 -9.44 -0.46 6.38e-19 Type 2 diabetes; LUSC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg18681998 chr4:17616180 MED28 -0.82 -14.09 -0.61 1.02e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7829975 0.593 rs2921061 chr8:8317615 A/T cg21775007 chr8:11205619 TDH 0.46 6.69 0.34 9.61e-11 Mood instability; LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7633857 0.512 rs745707 chr3:160652672 G/T cg03342759 chr3:160939853 NMD3 -0.41 -6.19 -0.32 1.72e-9 Educational attainment (years of education); LUSC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.96 0.48 1.2e-20 Bipolar disorder; LUSC cis rs6445967 0.530 rs12495722 chr3:58401595 C/T cg23715586 chr3:58305044 RPP14 0.42 7.18 0.37 4.61e-12 Platelet count; LUSC cis rs7267979 1.000 rs2482930 chr20:25334115 G/C cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.07e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg14668632 chr7:2872130 GNA12 0.44 6.29 0.33 1.02e-9 Height; LUSC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg21856205 chr7:94953877 PON1 -0.36 -5.73 -0.3 2.29e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg17264618 chr3:40429014 ENTPD3 0.34 6.05 0.31 3.89e-9 Renal cell carcinoma; LUSC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg05425664 chr17:57184151 TRIM37 -0.52 -7.83 -0.39 6.51e-14 Intelligence (multi-trait analysis); LUSC cis rs75920871 0.528 rs10892071 chr11:116954565 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.46 -0.33 3.68e-10 Subjective well-being; LUSC cis rs3892630 0.588 rs8106748 chr19:33282797 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.5 -5.72 -0.3 2.33e-8 Red blood cell traits; LUSC cis rs734999 0.545 rs28568531 chr1:2555640 T/A cg18932078 chr1:2524107 MMEL1 0.31 6.88 0.35 2.93e-11 Ulcerative colitis; LUSC cis rs7945705 0.776 rs2316865 chr11:8815470 A/G cg12365402 chr11:9010492 NRIP3 0.46 8.02 0.4 1.75e-14 Hemoglobin concentration; LUSC trans rs6089829 0.692 rs6122349 chr20:61664096 T/C cg15934090 chr1:100435551 SLC35A3 0.4 5.99 0.31 5.42e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4629180 1.000 rs908133 chr2:102092374 A/C cg01388757 chr2:102091195 RFX8 -0.44 -7.01 -0.36 1.33e-11 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7582180 0.629 rs13025184 chr2:100944842 A/G cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs6690583 0.562 rs6688354 chr1:85520854 A/G cg11262906 chr1:85462892 MCOLN2 0.68 6.32 0.33 8.43e-10 Serum sulfate level; LUSC cis rs2282032 0.527 rs2282033 chr14:90769635 G/T cg14092571 chr14:90743983 NA -0.45 -7.74 -0.39 1.19e-13 Longevity; LUSC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg24147428 chr11:65409760 SIPA1 -0.54 -7.65 -0.39 2.2e-13 Blood pressure (age interaction); LUSC cis rs17401966 0.540 rs6541084 chr1:10285447 A/G cg17425144 chr1:10567563 PEX14 -0.34 -6.05 -0.31 3.83e-9 Hepatocellular carcinoma; LUSC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg08917208 chr2:24149416 ATAD2B 0.55 6.24 0.32 1.35e-9 Lymphocyte counts; LUSC cis rs921968 0.643 rs2303561 chr2:219527005 C/T cg02176678 chr2:219576539 TTLL4 -0.59 -10.58 -0.5 9.39e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs2324229 0.828 rs1180238 chr6:83943666 G/A cg08257003 chr6:84140564 ME1 0.27 6.23 0.32 1.37e-9 Platelet-derived growth factor BB levels; LUSC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.14e-30 Aortic root size; LUSC cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs9300255 0.569 rs1716170 chr12:123716513 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.22 -0.32 1.48e-9 Neutrophil percentage of white cells; LUSC trans rs7937682 0.924 rs495460 chr11:111504777 G/A cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs2204008 0.666 rs67792345 chr12:38204698 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.61 0.65 1.21e-41 Bladder cancer; LUSC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg15445000 chr17:37608096 MED1 -0.39 -6.8 -0.35 4.94e-11 Glomerular filtration rate (creatinine); LUSC trans rs11098499 0.754 rs1980025 chr4:120252806 A/G cg25214090 chr10:38739885 LOC399744 -0.42 -6.55 -0.34 2.21e-10 Corneal astigmatism; LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 13.87 0.6 7.19e-35 Platelet count; LUSC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg18850127 chr7:39170497 POU6F2 0.68 11.0 0.52 3.13e-24 IgG glycosylation; LUSC cis rs9948 0.655 rs62156216 chr2:97405127 C/T cg01990225 chr2:97406019 LMAN2L -1.03 -7.11 -0.36 7.29e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs67366981 1.000 rs57178676 chr14:77704595 A/C cg22824376 chr14:77648248 TMEM63C 0.68 6.39 0.33 5.43e-10 Obsessive-compulsive symptoms; LUSC cis rs2637266 1.000 rs4979784 chr10:78355476 T/A cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg16325326 chr1:53192061 ZYG11B 0.93 17.63 0.69 1.17e-49 Monocyte count; LUSC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg19774624 chr17:42201019 HDAC5 0.82 14.05 0.61 1.43e-35 Total body bone mineral density; LUSC cis rs17253792 0.822 rs74609892 chr14:56053002 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg14004847 chr7:1930337 MAD1L1 0.55 8.65 0.43 2.2e-16 Bipolar disorder and schizophrenia; LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg14668632 chr7:2872130 GNA12 -0.45 -6.52 -0.34 2.66e-10 Height; LUSC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg08975724 chr8:8085496 FLJ10661 0.48 7.39 0.37 1.17e-12 Mood instability; LUSC cis rs3820068 0.608 rs12092485 chr1:16048038 A/G cg24675056 chr1:15929824 NA 0.42 6.85 0.35 3.57e-11 Systolic blood pressure; LUSC cis rs317689 0.680 rs315140 chr12:69790780 A/T cg11871910 chr12:69753446 YEATS4 0.6 8.08 0.4 1.17e-14 Response to diuretic therapy; LUSC cis rs4842666 0.915 rs73437358 chr12:90072076 G/A cg00757033 chr12:89920650 WDR51B 0.5 7.13 0.36 6.44e-12 Blood pressure; LUSC trans rs8055236 0.564 rs7187443 chr16:83197057 C/G cg27022570 chr14:50155261 POLE2 0.44 5.96 0.31 6.5e-9 Coronary heart disease; LUSC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg18512352 chr11:47633146 NA 0.46 9.33 0.45 1.56e-18 Subjective well-being; LUSC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg00033643 chr7:134001901 SLC35B4 0.43 6.64 0.34 1.3100000000000001e-10 Mean platelet volume; LUSC cis rs983392 0.805 rs11230180 chr11:59961486 A/C cg02771260 chr11:59836817 MS4A3 0.39 5.84 0.3 1.22e-8 Alzheimer's disease (late onset); LUSC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg25319279 chr11:5960081 NA -0.48 -6.53 -0.34 2.49e-10 DNA methylation (variation); LUSC cis rs67311347 0.713 rs9861194 chr3:40309225 C/T cg02782426 chr3:40428986 ENTPD3 0.34 6.82 0.35 4.33e-11 Renal cell carcinoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06199468 chr16:58163354 C16orf80 -0.44 -6.45 -0.33 3.85e-10 Electrocardiographic conduction measures; LUSC cis rs2019216 0.542 rs8073228 chr17:21909838 C/G cg22648282 chr17:21454238 C17orf51 -0.53 -7.8 -0.39 8.14e-14 Pelvic organ prolapse; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg00149659 chr3:10157352 C3orf10 0.88 12.31 0.56 5.78e-29 Alzheimer's disease; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.74 -13.19 -0.59 2.77e-32 Personality dimensions; LUSC cis rs2932538 0.922 rs7551933 chr1:113086706 C/T cg22162597 chr1:113214053 CAPZA1 -0.62 -9.3 -0.45 1.93e-18 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs629535 0.783 rs538832 chr8:70033817 A/G cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs983392 0.755 rs569046 chr11:59911161 C/G cg24026212 chr11:59952134 MS4A6A -0.31 -5.71 -0.3 2.45e-8 Alzheimer's disease (late onset); LUSC cis rs9296092 0.517 rs62405895 chr6:33471969 G/T cg13560919 chr6:33536144 NA -0.82 -13.93 -0.61 4.42e-35 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg03060546 chr3:49711283 APEH 0.72 12.14 0.55 2.46e-28 Resting heart rate; LUSC cis rs7258465 1.000 rs4808136 chr19:18618867 A/G cg06462663 chr19:18546047 ISYNA1 -0.45 -7.97 -0.4 2.61e-14 Breast cancer; LUSC cis rs11645898 0.935 rs4788615 chr16:72192372 G/A cg14768367 chr16:72042858 DHODH -0.66 -7.24 -0.37 3.2e-12 Blood protein levels; LUSC cis rs6546886 0.912 rs9309478 chr2:74305203 G/C cg14702570 chr2:74259524 NA -0.3 -5.8 -0.3 1.56e-8 Dialysis-related mortality; LUSC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg21951975 chr1:209979733 IRF6 0.56 6.86 0.35 3.26e-11 Coronary artery disease; LUSC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg11871910 chr12:69753446 YEATS4 0.83 14.62 0.62 8.94e-38 Blood protein levels; LUSC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg20608306 chr11:116969690 SIK3 0.39 6.38 0.33 5.81e-10 Blood protein levels; LUSC cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.38e-12 Motion sickness; LUSC cis rs12220238 1.000 rs12252705 chr10:75984863 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.0 0.36 1.39e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1949733 0.598 rs16842480 chr4:8535621 G/T cg13073564 chr4:8508604 NA 0.34 6.28 0.32 1.08e-9 Response to antineoplastic agents; LUSC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03352830 chr11:487213 PTDSS2 0.72 8.68 0.43 1.82e-16 Body mass index; LUSC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.94 -0.31 7.08e-9 Life satisfaction; LUSC cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.47 0.33 3.46e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9902453 0.817 rs2321333 chr17:28140857 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.67 0.54 1.29e-26 Coffee consumption (cups per day); LUSC cis rs2658782 0.615 rs2605615 chr11:93233068 G/A cg15737290 chr11:93063684 CCDC67 0.63 8.12 0.41 9.26e-15 Pulmonary function decline; LUSC cis rs9788721 0.900 rs72740964 chr15:78868636 G/A cg06917634 chr15:78832804 PSMA4 -0.44 -5.92 -0.31 7.96e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg05623727 chr3:50126028 RBM5 -0.33 -6.18 -0.32 1.87e-9 Body mass index; LUSC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg18240062 chr17:79603768 NPLOC4 0.79 15.37 0.64 1.04e-40 Eye color traits; LUSC cis rs939658 1.000 rs939658 chr15:79451869 A/G cg17916960 chr15:79447300 NA 0.47 9.33 0.45 1.54e-18 Refractive error; LUSC cis rs4319547 0.695 rs1803290 chr12:122865029 T/C cg23029597 chr12:123009494 RSRC2 0.74 9.36 0.46 1.24e-18 Body mass index; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg06263672 chr7:65235340 NA 0.44 6.34 0.33 7.28e-10 Calcium levels; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg04025307 chr7:1156635 C7orf50 0.52 8.13 0.41 8.77e-15 Longevity;Endometriosis; LUSC cis rs4595586 0.525 rs11612680 chr12:39344443 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.49 0.33 3.11e-10 Morning vs. evening chronotype; LUSC trans rs8022206 0.740 rs1950764 chr14:68343363 G/A cg15809352 chr2:121748218 GLI2 0.46 6.67 0.34 1.08e-10 Platelet count;Mean platelet volume; LUSC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.64 0.39 2.35e-13 Bipolar disorder; LUSC cis rs9354308 0.933 rs2802063 chr6:66564148 T/C cg07460842 chr6:66804631 NA 0.49 5.97 0.31 6.2e-9 Metabolite levels; LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.11 0.36 7.1e-12 Bipolar disorder; LUSC cis rs7727544 0.545 rs10074490 chr5:131340032 C/T cg14196790 chr5:131705035 SLC22A5 0.47 7.74 0.39 1.21e-13 Blood metabolite levels; LUSC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg04972856 chr6:88032051 C6orf162;GJB7 0.51 10.1 0.48 4.02e-21 Monocyte percentage of white cells; LUSC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg20243544 chr17:37824526 PNMT 0.58 8.28 0.41 3.06e-15 Asthma; LUSC cis rs11971779 0.680 rs6978680 chr7:139112048 A/G cg07862535 chr7:139043722 LUC7L2 -0.54 -6.75 -0.35 6.59e-11 Diisocyanate-induced asthma; LUSC trans rs870142 0.883 rs73203671 chr4:4641587 G/A cg04017672 chr1:182359056 GLUL 0.4 5.99 0.31 5.39e-9 Congenital heart disease; LUSC cis rs4889855 0.516 rs4890041 chr17:78521114 A/T cg16591659 chr17:78472290 NA 0.31 5.68 0.3 2.99e-8 Fractional excretion of uric acid; LUSC cis rs9921338 0.961 rs7206749 chr16:11376922 T/C cg00044050 chr16:11439710 C16orf75 -0.5 -6.97 -0.36 1.74e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs7937682 0.921 rs34584980 chr11:111441537 G/A cg19812747 chr11:111475976 SIK2 0.54 7.57 0.38 3.65e-13 Primary sclerosing cholangitis; LUSC cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs61931739 0.517 rs1843737 chr12:34015305 A/G cg06521331 chr12:34319734 NA -0.47 -8.04 -0.4 1.55e-14 Morning vs. evening chronotype; LUSC cis rs66887589 0.777 rs10015883 chr4:120268146 A/G cg09307838 chr4:120376055 NA 0.52 7.81 0.39 7.33e-14 Diastolic blood pressure; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg16145915 chr7:1198662 ZFAND2A -0.52 -10.16 -0.49 2.59e-21 Longevity;Endometriosis; LUSC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg00944433 chr1:107599041 PRMT6 -0.36 -6.66 -0.34 1.15e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg04511125 chr2:88470314 THNSL2 -0.43 -6.45 -0.33 3.91e-10 Response to metformin (IC50); LUSC trans rs10096351 0.550 rs78015822 chr8:128336740 A/G cg10897648 chr18:56338258 MALT1 -0.42 -6.24 -0.32 1.33e-9 Breast cancer; LUSC trans rs7726839 0.540 rs72703092 chr5:599269 G/A cg11887960 chr12:57824829 NA 0.54 6.74 0.35 7.11e-11 Obesity-related traits; LUSC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg05368731 chr17:41323189 NBR1 0.83 13.64 0.6 5.74e-34 Menopause (age at onset); LUSC cis rs17095355 1.000 rs975442 chr10:111705895 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.62 -0.38 2.6e-13 Biliary atresia; LUSC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg23711669 chr6:146136114 FBXO30 0.77 12.42 0.56 2.28e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs6547741 0.775 rs11692692 chr2:27861707 G/A cg12559939 chr2:27858050 GPN1 -0.41 -6.26 -0.32 1.2e-9 Oral cavity cancer; LUSC cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.81 -0.51 1.5e-23 Alzheimer's disease (late onset); LUSC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs9653442 0.866 rs12712065 chr2:100761105 C/G cg22139774 chr2:100720529 AFF3 -0.52 -9.09 -0.45 9.3e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg02187348 chr16:89574699 SPG7 0.61 10.13 0.48 3.21e-21 Multiple myeloma (IgH translocation); LUSC cis rs2635047 0.811 rs28471970 chr18:44788439 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 5.7 0.3 2.68e-8 Educational attainment; LUSC cis rs10464366 0.560 rs12701692 chr7:39135551 A/G cg20302533 chr7:39170763 POU6F2 0.49 7.94 0.4 3.19e-14 IgG glycosylation; LUSC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg17971929 chr21:40555470 PSMG1 0.79 13.69 0.6 3.66e-34 Cognitive function; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26468205 chr20:62886904 PCMTD2 -0.51 -6.08 -0.32 3.37e-9 Bipolar disorder and schizophrenia; LUSC cis rs453301 0.631 rs13250781 chr8:8793343 T/G cg08975724 chr8:8085496 FLJ10661 -0.41 -6.09 -0.32 3.13e-9 Joint mobility (Beighton score); LUSC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg22800045 chr5:56110881 MAP3K1 0.45 6.35 0.33 6.95e-10 Breast cancer;Breast cancer (early onset); LUSC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.41 -6.43 -0.33 4.36e-10 Mean platelet volume; LUSC cis rs9311676 0.656 rs6799077 chr3:58404096 C/T cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg14004847 chr7:1930337 MAD1L1 -0.52 -8.11 -0.41 9.71e-15 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg08219700 chr8:58056026 NA 0.47 6.18 0.32 1.83e-9 Developmental language disorder (linguistic errors); LUSC cis rs12681288 0.578 rs10503154 chr8:969343 C/G cg15309053 chr8:964076 NA 0.4 8.03 0.4 1.66e-14 Schizophrenia; LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg10263370 chr3:44754102 ZNF502 -0.37 -5.88 -0.31 1.01e-8 Depressive symptoms; LUSC cis rs8060686 0.516 rs8044995 chr16:68189340 G/A cg09835421 chr16:68378352 PRMT7 -0.46 -5.77 -0.3 1.83e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs9914988 1.000 rs9895443 chr17:27182944 A/G cg09479241 chr17:27052676 TLCD1 0.44 6.24 0.32 1.35e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7246657 0.722 rs2927742 chr19:38133618 T/C cg23950597 chr19:37808831 NA 0.49 5.67 0.3 3.11e-8 Coronary artery calcification; LUSC cis rs4969178 0.600 rs2376583 chr17:76402105 A/T cg05887092 chr17:76393375 PGS1 0.6 11.41 0.53 1.12e-25 HDL cholesterol levels; LUSC cis rs6430585 0.528 rs309142 chr2:136715324 T/C cg07169764 chr2:136633963 MCM6 1.03 16.47 0.67 4.8e-45 Corneal structure; LUSC trans rs561341 1.000 rs561341 chr17:30316385 T/G cg20587970 chr11:113659929 NA -1.31 -18.22 -0.71 5.26e-52 Hip circumference adjusted for BMI; LUSC cis rs748404 0.697 rs1814323 chr15:43563237 T/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.43 -6.02 -0.31 4.63e-9 Lung cancer; LUSC cis rs372883 0.935 rs1153295 chr21:30704080 T/G cg24692254 chr21:30365293 RNF160 -0.41 -5.7 -0.3 2.57e-8 Pancreatic cancer; LUSC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.41 0.33 4.97e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg13114125 chr14:105738426 BRF1 -0.96 -16.4 -0.67 9.45e-45 Mean platelet volume;Platelet distribution width; LUSC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg18402987 chr7:1209562 NA 0.55 5.98 0.31 5.65e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs68170813 0.559 rs80153759 chr7:106944145 C/A cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.64 -0.3 3.56e-8 Coronary artery disease; LUSC cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9633740 0.578 rs7084416 chr10:82304297 G/A cg01528321 chr10:82214614 TSPAN14 -0.72 -6.98 -0.36 1.56e-11 Post bronchodilator FEV1; LUSC cis rs2227564 0.729 rs2688616 chr10:75650652 G/C cg23231163 chr10:75533350 FUT11 -0.43 -5.88 -0.31 9.97e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg00343986 chr7:65444356 GUSB -0.38 -5.73 -0.3 2.29e-8 Aortic root size; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.17 0.55 1.94e-28 Prudent dietary pattern; LUSC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg26513180 chr16:89883248 FANCA -0.85 -13.77 -0.6 1.75e-34 Vitiligo; LUSC cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg21466736 chr12:48725269 NA 0.34 6.1 0.32 2.97e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs10876993 0.928 rs1689592 chr12:58057773 C/T cg18357645 chr12:58087776 OS9 0.55 8.34 0.42 1.95e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg11062466 chr8:58055876 NA 0.61 7.5 0.38 5.71e-13 Developmental language disorder (linguistic errors); LUSC cis rs13401104 0.796 rs1968708 chr2:237110654 G/A cg19324714 chr2:237145437 ASB18 0.43 5.79 0.3 1.6e-8 Educational attainment; LUSC cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg12863693 chr15:85201151 NMB 0.38 8.08 0.4 1.17e-14 Schizophrenia; LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.47 6.0 0.31 5.1e-9 Renal function-related traits (BUN); LUSC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.05 -0.36 1.01e-11 Developmental language disorder (linguistic errors); LUSC cis rs1506636 1.000 rs666266 chr7:123417759 A/G cg03229431 chr7:123269106 ASB15 0.65 10.68 0.5 4.29e-23 Plateletcrit;Platelet count; LUSC cis rs72634258 0.699 rs12128234 chr1:8170219 T/C cg00042356 chr1:8021962 PARK7 -0.59 -7.17 -0.37 4.76e-12 Inflammatory bowel disease; LUSC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg10130564 chr11:117069849 TAGLN 0.39 6.66 0.34 1.16e-10 Blood protein levels; LUSC cis rs7267979 0.745 rs6132845 chr20:25547767 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.74 14.86 0.63 1.09e-38 Liver enzyme levels (alkaline phosphatase); LUSC cis rs73195822 0.667 rs73194062 chr12:111223294 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.7 0.34 9.1e-11 Itch intensity from mosquito bite; LUSC cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg00012203 chr2:219082015 ARPC2 -0.58 -9.43 -0.46 7.27e-19 Ulcerative colitis; LUSC cis rs9300255 0.602 rs941305 chr12:123715266 T/C cg00376283 chr12:123451042 ABCB9 0.65 8.3 0.41 2.63e-15 Neutrophil percentage of white cells; LUSC cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg24130564 chr14:104152367 KLC1 -0.4 -5.7 -0.3 2.66e-8 Body mass index; LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg08088566 chr11:430123 ANO9 0.66 7.32 0.37 1.82e-12 Body mass index; LUSC cis rs34779708 0.966 rs2505639 chr10:35474421 A/G cg03585969 chr10:35415529 CREM -0.59 -8.94 -0.44 2.77e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2324229 0.828 rs1180185 chr6:83970313 T/G cg08257003 chr6:84140564 ME1 0.34 8.01 0.4 1.97e-14 Platelet-derived growth factor BB levels; LUSC cis rs2637266 0.655 rs846595 chr10:78531300 C/T cg18941641 chr10:78392320 NA 0.39 7.08 0.36 8.35e-12 Pulmonary function; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg09436375 chr6:42928200 GNMT -0.29 -6.82 -0.35 4.27e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11583043 0.667 rs4617425 chr1:101543205 C/A cg11406453 chr1:101602562 NA -0.4 -6.68 -0.34 9.91e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4906332 1.000 rs35224956 chr14:103900481 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.46e-12 Coronary artery disease; LUSC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg13939156 chr17:80058883 NA -0.33 -6.46 -0.33 3.6e-10 Life satisfaction; LUSC cis rs6005807 0.545 rs12169120 chr22:29005302 A/C cg12565055 chr22:29076175 TTC28 0.54 5.79 0.3 1.62e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg04398451 chr17:18023971 MYO15A 0.51 8.11 0.41 9.49e-15 Total body bone mineral density; LUSC cis rs4698790 0.914 rs7671905 chr4:110722886 T/C cg07850274 chr4:110748770 RRH 0.4 6.17 0.32 1.98e-9 Fasting insulin (dietary factor interaction);Homeostasis model assessment of insulin resistance (dietary factor interaction); LUSC cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg06784218 chr1:46089804 CCDC17 0.51 9.72 0.47 7.88e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg07424592 chr7:64974309 NA -0.64 -5.73 -0.3 2.24e-8 Diabetic kidney disease; LUSC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.98 0.36 1.57e-11 Intelligence (multi-trait analysis); LUSC cis rs11048434 0.736 rs11048337 chr12:9121330 C/A cg04155231 chr12:9217510 LOC144571 0.3 5.73 0.3 2.3e-8 Sjögren's syndrome; LUSC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.84 0.44 5.53e-17 Schizophrenia; LUSC cis rs7647973 0.593 rs9870755 chr3:49809841 A/G cg13072238 chr3:49761600 GMPPB -0.59 -7.82 -0.39 6.94e-14 Menarche (age at onset); LUSC cis rs10761482 0.813 rs7083624 chr10:62121239 G/C cg18175470 chr10:62150864 ANK3 -0.51 -7.31 -0.37 2.03e-12 Schizophrenia; LUSC cis rs11155671 0.530 rs6939761 chr6:150210994 T/C cg07701084 chr6:150067640 NUP43 0.46 6.93 0.35 2.23e-11 Testicular germ cell tumor; LUSC cis rs7296418 0.699 rs11057254 chr12:123794581 A/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.09 -0.4 1.15e-14 Platelet count; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg00149659 chr3:10157352 C3orf10 0.94 12.69 0.57 2.21e-30 Alzheimer's disease; LUSC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg13647721 chr17:30228624 UTP6 0.54 5.91 0.31 8.42e-9 Hip circumference adjusted for BMI; LUSC cis rs796825 0.530 rs1492272 chr3:119962322 G/C cg21790991 chr3:120137480 FSTL1 -0.34 -5.98 -0.31 5.68e-9 HIV-1 susceptibility; LUSC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg13072238 chr3:49761600 GMPPB -0.65 -7.74 -0.39 1.17e-13 Menarche (age at onset); LUSC cis rs10638925 1 rs10638925 chr3:194119749 C/CCATAAA cg00834899 chr3:194121120 GP5 0.66 12.7 0.57 2.04e-30 Platelet distribution width; LUSC trans rs61931739 0.534 rs11052974 chr12:34029877 T/G cg26384229 chr12:38710491 ALG10B 0.72 11.31 0.53 2.59e-25 Morning vs. evening chronotype; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg09267113 chr7:98030324 BAIAP2L1 0.41 6.19 0.32 1.75e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1018697 1.000 rs2150928 chr10:104550985 G/A cg04362960 chr10:104952993 NT5C2 0.47 6.48 0.33 3.29e-10 Colorectal adenoma (advanced); LUSC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg05368731 chr17:41323189 NBR1 0.95 16.07 0.66 1.92e-43 Menopause (age at onset); LUSC cis rs6060717 0.610 rs2590964 chr20:34613376 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.32 -0.33 8.6e-10 Hip circumference adjusted for BMI; LUSC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.88 0.4 4.55e-14 Total body bone mineral density; LUSC cis rs9457247 1.000 rs239935 chr6:167411788 G/A cg25258033 chr6:167368657 RNASET2 0.49 7.99 0.4 2.17e-14 Crohn's disease; LUSC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.44 6.52 0.34 2.54e-10 Systemic lupus erythematosus; LUSC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11890956 chr21:40555474 PSMG1 1.02 20.15 0.74 1.14e-59 Cognitive function; LUSC cis rs9436747 0.585 rs6662904 chr1:65997740 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.45 6.13 0.32 2.52e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.6 9.27 0.45 2.43e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3812762 0.843 rs2292046 chr11:8807179 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.39 6.86 0.35 3.32e-11 Hypospadias; LUSC cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs10782582 0.609 rs2029682 chr1:76341619 T/C cg10523679 chr1:76189770 ACADM -0.47 -6.71 -0.34 8.21e-11 Daytime sleep phenotypes; LUSC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg20933634 chr6:27740509 NA 0.4 5.87 0.31 1.06e-8 Parkinson's disease; LUSC cis rs7584330 1.000 rs7584330 chr2:238387228 A/G cg14458575 chr2:238380390 NA 0.68 11.54 0.53 3.84e-26 Prostate cancer; LUSC cis rs7647973 1.000 rs11720542 chr3:49357427 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.43 6.64 0.34 1.24e-10 Menarche (age at onset); LUSC cis rs12681287 0.547 rs7461366 chr8:87511685 C/T cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC trans rs61931739 0.513 rs2200555 chr12:33899381 C/G cg26384229 chr12:38710491 ALG10B 0.59 9.42 0.46 7.54e-19 Morning vs. evening chronotype; LUSC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg22166914 chr1:53195759 ZYG11B -0.55 -8.77 -0.43 9.2e-17 Monocyte count; LUSC cis rs3806843 0.933 rs2240696 chr5:140168070 A/G cg19875535 chr5:140030758 IK 0.51 8.37 0.42 1.55e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs554111 0.593 rs4654906 chr1:21509642 A/T cg01072550 chr1:21505969 NA -0.39 -5.82 -0.3 1.37e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg10645314 chr2:3704589 ALLC 0.49 7.88 0.4 4.66e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg04576048 chr1:205797593 PM20D1 0.34 6.13 0.32 2.51e-9 Menarche (age at onset); LUSC cis rs12618769 0.597 rs72821951 chr2:99157009 A/C cg10123293 chr2:99228465 UNC50 0.47 7.58 0.38 3.39e-13 Bipolar disorder; LUSC cis rs6918586 0.658 rs198844 chr6:26108282 C/G cg17691542 chr6:26056736 HIST1H1C 0.4 5.99 0.31 5.32e-9 Schizophrenia; LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg08859206 chr1:53392774 SCP2 -0.51 -8.75 -0.43 1.07e-16 Monocyte count; LUSC cis rs7523273 0.606 rs2761430 chr1:207912408 G/A cg22525895 chr1:207977042 MIR29B2 0.41 6.71 0.34 8.42e-11 Schizophrenia; LUSC trans rs7374394 1.000 rs2301052 chr3:184953662 C/T cg08270206 chr16:56623390 MT3 -0.47 -6.04 -0.31 4.14e-9 Cognitive performance; LUSC trans rs7726839 0.540 rs72703087 chr5:598029 C/T cg11887960 chr12:57824829 NA 0.54 6.74 0.35 7.11e-11 Obesity-related traits; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg11235426 chr6:292522 DUSP22 -0.66 -10.55 -0.5 1.18e-22 Menopause (age at onset); LUSC cis rs7197653 0.586 rs55856208 chr16:68324210 A/T cg09835421 chr16:68378352 PRMT7 -0.7 -7.49 -0.38 6.14e-13 Magnesium levels; LUSC cis rs7804356 1.000 rs1327989 chr7:26833563 C/T cg03456212 chr7:26904342 SKAP2 -0.55 -6.53 -0.34 2.46e-10 Type 1 diabetes; LUSC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg05855489 chr10:104503620 C10orf26 0.6 8.86 0.44 4.83e-17 Arsenic metabolism; LUSC cis rs12369635 1.000 rs73159540 chr12:129559421 C/T cg01909103 chr12:129572610 TMEM132D -0.6 -5.69 -0.3 2.82e-8 Schizophrenia (inflammation and infection response interaction); LUSC cis rs7000551 0.751 rs1116084 chr8:22395309 C/T cg12081754 chr8:22256438 SLC39A14 0.42 5.85 0.31 1.15e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg01238044 chr22:24384105 GSTT1 -0.54 -7.89 -0.4 4.41e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg03146154 chr1:46216737 IPP 0.56 8.32 0.41 2.35e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 6.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg17063962 chr7:91808500 NA 0.57 8.78 0.43 8.71e-17 Breast cancer; LUSC cis rs4478137 0.501 rs6828399 chr4:164228471 T/C cg06758707 chr4:164254230 NPY1R -0.52 -6.95 -0.36 1.91e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs427941 0.703 rs201446 chr7:101738323 C/G cg06246474 chr7:101738831 CUX1 0.41 6.71 0.34 8.45e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg05347473 chr6:146136440 FBXO30 0.48 7.9 0.4 4.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4969178 0.931 rs3826323 chr17:76400268 C/G cg20026190 chr17:76395443 PGS1 0.46 8.2 0.41 5.33e-15 HDL cholesterol levels; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg07677032 chr17:61819896 STRADA 0.52 8.63 0.43 2.54e-16 Prudent dietary pattern; LUSC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg14993813 chr1:46806288 NSUN4 -0.53 -7.33 -0.37 1.77e-12 Menopause (age at onset); LUSC cis rs59698941 0.943 rs55746968 chr5:132298188 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC trans rs12210905 0.925 rs10946896 chr6:26988576 A/G cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs7605827 0.930 rs13017972 chr2:15699739 A/G cg19274914 chr2:15703543 NA 0.48 9.24 0.45 2.91e-18 Educational attainment (years of education); LUSC cis rs11711311 1.000 rs9879760 chr3:113457948 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg07741184 chr6:167504864 NA 0.34 6.13 0.32 2.45e-9 Crohn's disease; LUSC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg07677032 chr17:61819896 STRADA 0.54 8.93 0.44 2.86e-17 Prudent dietary pattern; LUSC cis rs12493885 0.818 rs11928425 chr3:153773565 G/T cg17054900 chr3:154042577 DHX36 -0.54 -5.76 -0.3 1.89e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs34375054 0.525 rs10846829 chr12:125595058 G/C cg06287003 chr12:125626642 AACS -0.39 -6.81 -0.35 4.55e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs611744 0.647 rs1448151 chr8:109276283 C/A cg18478394 chr8:109455254 TTC35 0.43 6.79 0.35 5.05e-11 Dupuytren's disease; LUSC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg10523679 chr1:76189770 ACADM 0.85 14.01 0.61 2.17e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg11494091 chr17:61959527 GH2 0.4 6.85 0.35 3.62e-11 Height; LUSC cis rs9814567 1.000 rs9864439 chr3:134298671 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.55 -0.6 1.2e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg22907277 chr7:1156413 C7orf50 0.46 7.17 0.37 4.82e-12 Longevity;Endometriosis; LUSC cis rs360798 0.532 rs2421816 chr2:63075033 C/A cg17519650 chr2:63277830 OTX1 0.47 6.44 0.33 4.08e-10 Coronary artery disease; LUSC trans rs9929218 0.559 rs11642362 chr16:68811307 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.96 18.93 0.72 8.39e-55 Colorectal cancer; LUSC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg07343612 chr16:622815 PIGQ -0.73 -12.49 -0.56 1.22e-29 Height; LUSC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg05425664 chr17:57184151 TRIM37 0.52 7.76 0.39 1.04e-13 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg18099408 chr3:52552593 STAB1 -0.41 -7.1 -0.36 7.78e-12 Bipolar disorder; LUSC trans rs800082 0.802 rs2717380 chr3:144256908 A/T cg24215973 chr2:240111563 HDAC4 0.41 6.15 0.32 2.21e-9 Smoking behavior; LUSC cis rs2404602 0.669 rs12595313 chr15:76978370 A/G cg22467129 chr15:76604101 ETFA -0.45 -7.05 -0.36 1.02e-11 Blood metabolite levels; LUSC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg18230493 chr5:56204884 C5orf35 -0.56 -8.76 -0.43 9.83e-17 Coronary artery disease; LUSC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.26 0.41 3.48e-15 Hemoglobin concentration; LUSC trans rs2739330 0.731 rs2000468 chr22:24241611 G/T cg06437703 chr8:37914619 EIF4EBP1 -0.59 -9.82 -0.47 3.59e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg26384229 chr12:38710491 ALG10B -0.63 -9.82 -0.47 3.55e-20 Morning vs. evening chronotype; LUSC cis rs3087591 0.708 rs17885030 chr17:29655218 C/T cg24425628 chr17:29625626 OMG;NF1 0.47 7.05 0.36 1.06e-11 Hip circumference; LUSC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg22903471 chr2:27725779 GCKR -0.42 -7.05 -0.36 1.02e-11 Total body bone mineral density; LUSC cis rs2985684 0.841 rs2281836 chr14:50065717 G/C cg04989706 chr14:50066350 PPIL5 -0.49 -6.31 -0.33 8.83e-10 Carotid intima media thickness; LUSC cis rs12368653 0.666 rs799267 chr12:58113158 C/T cg12615879 chr12:58013172 SLC26A10 0.36 8.33 0.41 2.05e-15 Multiple sclerosis; LUSC cis rs2282300 0.653 rs12800124 chr11:30239865 A/G cg06241208 chr11:30344200 C11orf46 -0.44 -5.65 -0.3 3.52e-8 Morning vs. evening chronotype; LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg08219700 chr8:58056026 NA 0.56 7.69 0.39 1.62e-13 Developmental language disorder (linguistic errors); LUSC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg22903471 chr2:27725779 GCKR -0.41 -6.96 -0.36 1.8e-11 Total body bone mineral density; LUSC cis rs12137294 0.866 rs1172156 chr1:205220087 C/T cg21643547 chr1:205240462 TMCC2 -0.35 -6.36 -0.33 6.53e-10 Red cell distribution width; LUSC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.96e-11 Blood metabolite levels; LUSC cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg01689657 chr7:91764605 CYP51A1 0.32 5.84 0.3 1.25e-8 Breast cancer; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg11965913 chr1:205819406 PM20D1 0.59 10.26 0.49 1.17e-21 Menarche (age at onset); LUSC cis rs11677416 1.000 rs6542093 chr2:113528536 G/A cg27083787 chr2:113543245 IL1A 0.44 6.97 0.36 1.65e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs6060717 0.610 rs2590965 chr20:34613120 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.63 0.34 1.36e-10 Hip circumference adjusted for BMI; LUSC cis rs11785400 0.793 rs2976399 chr8:143746050 C/T cg10596483 chr8:143751796 JRK 0.54 7.64 0.39 2.37e-13 Schizophrenia; LUSC cis rs8072100 0.905 rs8077106 chr17:45653291 T/G cg25173405 chr17:45401733 C17orf57 0.38 6.05 0.31 3.96e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg17724175 chr1:150552817 MCL1 0.35 6.23 0.32 1.44e-9 Melanoma; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -8.75 -0.43 1.09e-16 Lymphocyte counts; LUSC cis rs8060686 0.623 rs2418736 chr16:68154862 A/G cg26727032 chr16:67993705 SLC12A4 0.38 5.87 0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7914558 1.000 rs10786740 chr10:104935593 G/C cg04362960 chr10:104952993 NT5C2 0.59 9.36 0.46 1.22e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs5167 0.781 rs11672748 chr19:45490192 A/G cg13119609 chr19:45449297 APOC2 0.34 5.79 0.3 1.61e-8 Blood protein levels; LUSC trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg27661571 chr11:113659931 NA -0.61 -6.87 -0.35 3.15e-11 Hip circumference adjusted for BMI; LUSC cis rs1670533 1.000 rs2045065 chr4:1052488 A/G cg27284194 chr4:1044797 NA 0.58 8.64 0.43 2.4e-16 Recombination rate (females); LUSC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg16405210 chr4:1374714 KIAA1530 -0.53 -7.89 -0.4 4.44e-14 Obesity-related traits; LUSC cis rs11785400 1.000 rs6995314 chr8:143749718 A/G cg10596483 chr8:143751796 JRK -0.6 -9.23 -0.45 3.19e-18 Schizophrenia; LUSC cis rs72781680 0.799 rs17508218 chr2:23976536 C/T cg08917208 chr2:24149416 ATAD2B 0.87 9.69 0.47 9.99e-20 Lymphocyte counts; LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.45 0.46 5.94e-19 Bipolar disorder; LUSC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg22508957 chr16:3507546 NAT15 -0.66 -11.05 -0.52 2.09e-24 Tuberculosis; LUSC cis rs7953508 0.750 rs7977788 chr12:93982332 G/A cg18151635 chr12:93972918 NA -0.55 -7.91 -0.4 3.91e-14 Pubertal anthropometrics; LUSC trans rs11098499 0.954 rs66506550 chr4:120371445 T/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs6736093 0.796 rs34240639 chr2:112809951 T/A cg12686935 chr2:112915763 FBLN7 -0.4 -6.35 -0.33 7.12e-10 Coronary artery disease; LUSC cis rs73198271 0.960 rs10503392 chr8:8609555 G/C cg01851573 chr8:8652454 MFHAS1 0.6 8.32 0.41 2.28e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs9969804 0.782 rs10761169 chr9:95515033 T/C cg25594165 chr10:83637420 NRG3 0.32 6.09 0.32 3.04e-9 Height; LUSC cis rs6460942 0.908 rs79175014 chr7:12245378 T/G cg06484146 chr7:12443880 VWDE -0.59 -5.87 -0.31 1.02e-8 Coronary artery disease; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg08736216 chr1:53307985 ZYG11A -0.28 -5.75 -0.3 1.97e-8 Monocyte count; LUSC cis rs6543140 0.964 rs1035126 chr2:103019981 C/T cg09003973 chr2:102972529 NA 0.57 7.44 0.38 8.7e-13 Blood protein levels; LUSC cis rs11098499 0.588 rs2389874 chr4:120554991 A/G cg24375607 chr4:120327624 NA -0.63 -10.12 -0.48 3.51e-21 Corneal astigmatism; LUSC cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg06784218 chr1:46089804 CCDC17 -0.56 -10.93 -0.51 5.46e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7223966 1.000 rs9912201 chr17:61763208 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.63 0.34 1.34e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1448094 0.967 rs2121892 chr12:86324556 G/T cg18827107 chr12:86230957 RASSF9 -0.41 -5.99 -0.31 5.43e-9 Major depressive disorder; LUSC cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg27446573 chr6:127587934 RNF146 0.92 15.23 0.64 3.94e-40 Breast cancer; LUSC cis rs10911232 0.507 rs10911234 chr1:183053001 A/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Hypertriglyceridemia; LUSC cis rs2235544 0.565 rs635045 chr1:54469109 A/G cg25741118 chr1:54482237 LDLRAD1 0.29 6.06 0.31 3.64e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg07092213 chr7:1199455 ZFAND2A -0.44 -6.67 -0.34 1.05e-10 Longevity;Endometriosis; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg25703541 chr22:24373054 LOC391322 -0.89 -14.49 -0.62 2.83e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg22166914 chr1:53195759 ZYG11B 0.63 10.29 0.49 9.68e-22 Monocyte count; LUSC cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg20283391 chr11:68216788 NA -0.58 -8.13 -0.41 8.67e-15 Total body bone mineral density; LUSC cis rs4901869 0.931 rs12891570 chr14:59334338 T/A cg02291164 chr14:59296302 NA 0.58 10.98 0.51 3.78e-24 Panic disorder; LUSC cis rs1568889 0.838 rs6484359 chr11:28262328 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 12.94 0.58 2.53e-31 Bipolar disorder; LUSC cis rs929354 0.713 rs7798816 chr7:156940574 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC cis rs10992471 0.630 rs10453241 chr9:95198887 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.86 -0.35 3.32e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg07703079 chr11:430292 ANO9 0.67 6.91 0.35 2.45e-11 Body mass index; LUSC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg12257692 chr3:49977190 RBM6 0.24 6.69 0.34 9.53e-11 Intelligence (multi-trait analysis); LUSC cis rs1728785 1.000 rs1170442 chr16:68574064 G/T cg02508848 chr16:68573721 ZFP90 -0.42 -5.75 -0.3 2.07e-8 Ulcerative colitis; LUSC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 8.94 0.44 2.76e-17 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11489602 chr10:32345426 KIF5B -0.46 -6.13 -0.32 2.54e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg07677032 chr17:61819896 STRADA 0.54 8.88 0.44 4.33e-17 Prudent dietary pattern; LUSC cis rs7172677 1.000 rs4479194 chr15:75422131 C/T cg14664628 chr15:75095509 CSK -0.44 -5.82 -0.3 1.41e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg14664628 chr15:75095509 CSK 0.57 8.95 0.44 2.51e-17 Breast cancer; LUSC cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.74 0.43 1.15e-16 Menopause (age at onset); LUSC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 14.25 0.61 2.49e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11758351 0.587 rs16891456 chr6:26234127 T/C cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs710216 0.536 rs710222 chr1:43413653 A/G cg07803811 chr1:43423981 SLC2A1 0.41 6.27 0.32 1.09e-9 Red cell distribution width; LUSC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg11645453 chr3:52864694 ITIH4 0.31 7.12 0.36 6.56e-12 Bipolar disorder; LUSC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg16339924 chr4:17578868 LAP3 0.5 7.57 0.38 3.57e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17102423 0.685 rs4899161 chr14:65540901 G/A cg11161011 chr14:65562177 MAX -0.76 -11.16 -0.52 8.75e-25 Obesity-related traits; LUSC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg16524733 chr11:117070046 TAGLN 0.45 7.9 0.4 4.11e-14 Blood protein levels; LUSC cis rs849898 1 rs849898 chr1:228153917 A/G cg01973587 chr1:228161476 NA 0.38 6.29 0.33 9.73e-10 Parkinson's disease; LUSC cis rs1881396 0.531 rs4665386 chr2:27935352 C/A cg27432699 chr2:27873401 GPN1 0.68 7.94 0.4 3.03e-14 Nonalcoholic fatty liver disease; LUSC cis rs34330 0.562 rs7486387 chr12:12866911 G/A cg09462578 chr12:12878428 APOLD1 -0.63 -7.29 -0.37 2.3e-12 Systemic lupus erythematosus; LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg16606324 chr3:10149918 C3orf24 0.68 9.78 0.47 5.03e-20 Alzheimer's disease; LUSC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.18 0.32 1.82e-9 Systolic blood pressure; LUSC cis rs35146811 0.735 rs2528900 chr7:99805319 A/G cg13334819 chr7:99746414 C7orf59 0.5 6.73 0.35 7.39e-11 Coronary artery disease; LUSC cis rs7267979 1.000 rs884613 chr20:25288505 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.73 -0.7 4.71e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.99 -0.4 2.18e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg07606381 chr6:8435919 SLC35B3 0.74 12.48 0.56 1.36e-29 Motion sickness; LUSC cis rs1577917 0.958 rs9647601 chr6:86449827 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.82 -0.35 4.23e-11 Response to antipsychotic treatment; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg08548315 chr1:81609992 NA 0.38 6.09 0.32 3.09e-9 Cognitive function;Information processing speed; LUSC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg04352962 chr1:209979756 IRF6 0.53 6.31 0.33 9.08e-10 Cleft lip with or without cleft palate; LUSC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.28 0.32 1.08e-9 Tonsillectomy; LUSC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.7 -0.43 1.51e-16 Lung cancer; LUSC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg18252515 chr7:66147081 NA -1.22 -14.04 -0.61 1.61e-35 Diabetic kidney disease; LUSC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.92 -0.31 7.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11025559 0.643 rs11025570 chr11:20481109 T/A cg19653624 chr11:20408972 PRMT3 -0.74 -8.59 -0.43 3.47e-16 Pursuit maintenance gain; LUSC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.43 -0.33 4.52e-10 Lung cancer; LUSC trans rs1997103 0.954 rs9649854 chr7:55410213 G/A cg20935933 chr6:143382018 AIG1 0.5 7.28 0.37 2.42e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2742234 0.955 rs2503849 chr10:43672776 G/A cg02780029 chr10:43622663 RET -0.33 -5.98 -0.31 5.75e-9 Hirschsprung disease; LUSC cis rs7586879 0.639 rs4077678 chr2:25122840 C/G cg01884057 chr2:25150051 NA 0.47 11.11 0.52 1.3e-24 Body mass index; LUSC trans rs6582630 0.502 rs1115515 chr12:38279830 C/T cg06521331 chr12:34319734 NA -0.41 -6.34 -0.33 7.61e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs17604090 0.793 rs17150665 chr7:29688860 T/G cg19413766 chr7:29689036 LOC646762 -0.56 -7.01 -0.36 1.36e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7771547 0.642 rs668499 chr6:36496379 A/G cg07856975 chr6:36356162 ETV7 0.36 6.2 0.32 1.7e-9 Platelet distribution width; LUSC cis rs7681440 0.904 rs6816469 chr4:90772885 G/C cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.3 1.18e-8 Dementia with Lewy bodies; LUSC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg09044154 chr16:88155775 NA 0.55 7.53 0.38 4.81e-13 Menopause (age at onset); LUSC cis rs4947962 0.617 rs1558543 chr7:55135512 C/T cg23757825 chr7:55092271 EGFR -0.57 -6.69 -0.34 9.67e-11 Subjective response to lithium treatment; LUSC cis rs11690935 0.959 rs10204501 chr2:172588865 C/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.42 -0.62 5.29e-37 Schizophrenia; LUSC trans rs11098499 0.954 rs7437420 chr4:120312903 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.12 0.32 2.63e-9 Corneal astigmatism; LUSC cis rs27434 0.583 rs34764 chr5:96155229 A/G cg16492584 chr5:96139282 ERAP1 -0.58 -7.91 -0.4 3.9e-14 Ankylosing spondylitis; LUSC trans rs6956675 0.830 rs4585626 chr7:62671592 C/G cg01314568 chr7:57830625 NA 0.42 5.97 0.31 6.01e-9 Obesity-related traits; LUSC cis rs68170813 0.559 rs12532967 chr7:106937418 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.72 -0.47 7.9e-20 Coronary artery disease; LUSC cis rs870825 0.616 rs4623061 chr4:185643161 A/C cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg09359103 chr1:154839909 KCNN3 -0.69 -16.09 -0.66 1.52e-43 Prostate cancer; LUSC cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg06108461 chr20:60628389 TAF4 -0.93 -15.59 -0.65 1.53e-41 Body mass index; LUSC cis rs7927592 0.913 rs10896347 chr11:68353127 G/A cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.58e-9 Total body bone mineral density; LUSC cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.43 0.64 6.56e-41 Bladder cancer; LUSC cis rs738322 0.600 rs6001031 chr22:38556260 G/T cg25457927 chr22:38595422 NA 0.32 6.34 0.33 7.43e-10 Cutaneous nevi; LUSC cis rs6665290 0.669 rs34267809 chr1:227176162 C/G cg10327440 chr1:227177885 CDC42BPA -1.11 -28.87 -0.84 8.9e-93 Myeloid white cell count; LUSC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg07716408 chr11:68623521 NA -0.33 -6.25 -0.32 1.27e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg02675527 chr2:114030824 PAX8;LOC440839 0.37 5.75 0.3 2.07e-8 Lymphocyte counts; LUSC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg00599273 chr12:58146742 CDK4 0.31 5.85 0.3 1.18e-8 Multiple sclerosis; LUSC cis rs12618769 0.652 rs3769701 chr2:99195111 A/C cg10123293 chr2:99228465 UNC50 0.48 7.76 0.39 1.01e-13 Bipolar disorder; LUSC cis rs7804356 0.953 rs7785832 chr7:26852760 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg19592336 chr6:28129416 ZNF389 0.48 6.29 0.33 9.69e-10 Depression; LUSC cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22496380 chr5:211416 CCDC127 -0.87 -9.49 -0.46 4.54e-19 Breast cancer; LUSC cis rs4631830 0.863 rs2843549 chr10:51521247 C/A cg20129853 chr10:51489980 NA -0.32 -6.39 -0.33 5.63e-10 Prostate-specific antigen levels; LUSC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg04121214 chr22:50244548 NA -0.34 -5.74 -0.3 2.14e-8 Schizophrenia; LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg05025164 chr4:1340916 KIAA1530 0.65 9.98 0.48 1.08e-20 Longevity; LUSC cis rs8064299 0.597 rs9893035 chr17:72783798 A/C cg25054828 chr17:72772726 NAT9;TMEM104 0.94 19.3 0.73 2.66e-56 Monocyte count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11554771 chr1:6305590 HES3 0.41 5.94 0.31 6.98e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg03146154 chr1:46216737 IPP -0.55 -8.23 -0.41 4.16e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg06481639 chr22:41940642 POLR3H -0.5 -5.69 -0.3 2.78e-8 Vitiligo; LUSC cis rs7512552 0.966 rs10788873 chr1:150250534 T/A cg15654264 chr1:150340011 RPRD2 -0.61 -9.92 -0.48 1.76e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg15145296 chr3:125709740 NA -0.56 -6.73 -0.35 7.36e-11 Blood pressure (smoking interaction); LUSC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg23283495 chr1:209979779 IRF6 -0.54 -8.61 -0.43 2.94e-16 Monobrow; LUSC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs12908161 0.959 rs34342559 chr15:85331271 A/G cg17173187 chr15:85201210 NMB 0.48 8.78 0.43 8.71e-17 Schizophrenia; LUSC cis rs4803468 1.000 rs11883104 chr19:41923799 T/C cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.41 5.68 0.3 3e-8 Height; LUSC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg17143192 chr8:8559678 CLDN23 0.61 8.95 0.44 2.52e-17 Obesity-related traits; LUSC trans rs1814175 0.791 rs10769593 chr11:49616217 T/C cg15704280 chr7:45808275 SEPT13 -1.13 -23.13 -0.78 2.47e-71 Height; LUSC cis rs6494488 0.500 rs11854894 chr15:65020245 G/C cg08069370 chr15:64387884 SNX1 -0.65 -5.92 -0.31 7.91e-9 Coronary artery disease; LUSC cis rs62064224 0.702 rs735555 chr17:30817450 A/G cg18200150 chr17:30822561 MYO1D -0.34 -7.15 -0.36 5.44e-12 Schizophrenia; LUSC cis rs568617 0.859 rs1204650 chr11:65645580 A/C cg19792802 chr11:65647270 CTSW -0.41 -6.28 -0.32 1.05e-9 Crohn's disease; LUSC cis rs9902453 1.000 rs4239227 chr17:28389103 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC cis rs950169 0.922 rs4842939 chr15:84827966 C/T cg17507749 chr15:85114479 UBE2QP1 -0.57 -8.0 -0.4 2.06e-14 Schizophrenia; LUSC cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs79387448 0.745 rs7576324 chr2:103142994 G/A cg09003973 chr2:102972529 NA 0.82 8.12 0.41 9.02e-15 Gut microbiota (bacterial taxa); LUSC cis rs10751667 0.643 rs7394436 chr11:970373 G/C ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.19e-10 Alzheimer's disease (late onset); LUSC cis rs6060717 0.610 rs1891154 chr20:34617129 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -6.35 -0.33 7.18e-10 Hip circumference adjusted for BMI; LUSC cis rs7216064 0.861 rs73352810 chr17:65875184 G/A cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.85 -0.6 8.4e-35 Intelligence (multi-trait analysis); LUSC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg22590775 chr19:49891494 CCDC155 0.57 7.55 0.38 4.1e-13 Multiple sclerosis; LUSC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg14298792 chr15:30685198 CHRFAM7A 0.64 8.4 0.42 1.31e-15 Huntington's disease progression; LUSC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.51 0.59 1.76e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs9650315 0.777 rs5027179 chr8:57179633 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27026005 chr19:50380748 TBC1D17;AKT1S1 -0.53 -6.32 -0.33 8.13e-10 Bipolar disorder and schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06571993 chr7:98579529 TRRAP -0.81 -6.83 -0.35 3.98e-11 Cognitive performance; LUSC cis rs6121246 0.909 rs1994251 chr20:30287328 T/G cg18721089 chr20:30220636 NA -0.36 -6.19 -0.32 1.74e-9 Mean corpuscular hemoglobin; LUSC cis rs7408868 1.000 rs7245814 chr19:15274503 A/G cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.1e-18 Pulse pressure; LUSC cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg12165864 chr7:66369176 NA -0.53 -7.15 -0.36 5.51e-12 Corneal structure; LUSC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs7412746 0.566 rs11204743 chr1:150890406 A/T cg04414720 chr1:150670196 GOLPH3L 0.47 6.86 0.35 3.32e-11 Melanoma; LUSC cis rs300703 0.515 rs300693 chr2:181748 C/A cg21211680 chr2:198530 NA -0.54 -6.68 -0.34 9.72e-11 Blood protein levels; LUSC cis rs2629540 0.847 rs12247543 chr10:126419743 G/C cg08799069 chr10:126477246 METTL10 0.66 9.48 0.46 5.02e-19 Cocaine dependence; LUSC cis rs7572733 0.534 rs1435570 chr2:198731371 T/C cg00792783 chr2:198669748 PLCL1 0.44 5.94 0.31 7.12e-9 Dermatomyositis; LUSC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg03233332 chr7:66118400 NA 0.4 5.87 0.31 1.06e-8 Aortic root size; LUSC cis rs8060686 0.516 rs255052 chr16:68024995 C/T cg04539111 chr16:67997858 SLC12A4 -0.44 -6.08 -0.32 3.37e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17772535 chr12:65153236 GNS -0.51 -6.0 -0.31 5.06e-9 Bipolar disorder and schizophrenia; LUSC cis rs2439831 0.717 rs2470132 chr15:43835481 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.84 9.37 0.46 1.16e-18 Lung cancer in ever smokers; LUSC cis rs7572733 0.534 rs2060488 chr2:198751637 T/G cg00792783 chr2:198669748 PLCL1 0.46 6.15 0.32 2.17e-9 Dermatomyositis; LUSC trans rs561341 1.000 rs757009 chr17:30243937 A/G cg20587970 chr11:113659929 NA -1.04 -13.87 -0.6 7.41e-35 Hip circumference adjusted for BMI; LUSC trans rs7786808 0.615 rs4909212 chr7:158197037 G/T cg02030672 chr11:45687055 CHST1 0.55 8.9 0.44 3.7e-17 Obesity-related traits; LUSC cis rs4474465 0.915 rs10899504 chr11:78157983 C/A cg27205649 chr11:78285834 NARS2 -0.49 -5.85 -0.3 1.18e-8 Alzheimer's disease (survival time); LUSC cis rs8102476 0.773 rs11668070 chr19:38748913 G/A cg14131526 chr19:38747285 PPP1R14A -0.35 -6.12 -0.32 2.68e-9 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg11645453 chr3:52864694 ITIH4 0.35 8.2 0.41 5.41e-15 Electroencephalogram traits; LUSC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg13319975 chr6:146136371 FBXO30 -0.68 -10.51 -0.5 1.65e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg09877947 chr5:131593287 PDLIM4 0.36 6.06 0.31 3.61e-9 Blood metabolite levels; LUSC cis rs7772486 0.875 rs2777479 chr6:146309178 C/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.0 -0.36 1.38e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg08736216 chr1:53307985 ZYG11A -0.28 -6.03 -0.31 4.3e-9 Monocyte count; LUSC cis rs2439831 0.850 rs16977798 chr15:44151948 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.09 0.32 3.11e-9 Lung cancer in ever smokers; LUSC cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg00074818 chr8:8560427 CLDN23 0.58 9.85 0.47 2.86e-20 Obesity-related traits; LUSC trans rs7746199 0.736 rs58616630 chr6:27474715 A/G cg01620082 chr3:125678407 NA -0.78 -7.2 -0.37 4.02e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg15369054 chr17:80825471 TBCD 0.39 6.38 0.33 5.85e-10 Breast cancer; LUSC trans rs3733585 0.673 rs4311316 chr4:9955971 A/C cg26043149 chr18:55253948 FECH 0.46 7.23 0.37 3.25e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12971120 0.504 rs11665154 chr18:72147006 A/C cg26446133 chr18:72167187 CNDP2 -0.66 -9.63 -0.47 1.59e-19 Refractive error; LUSC cis rs10492096 0.947 rs10849484 chr12:6637941 C/T cg13857086 chr12:6580257 VAMP1 0.63 7.56 0.38 3.81e-13 Hip geometry; LUSC cis rs701145 1.000 rs355784 chr3:153986371 A/C cg17054900 chr3:154042577 DHX36 0.82 8.49 0.42 7.02e-16 Coronary artery disease; LUSC cis rs3916 0.662 rs2138249 chr12:121124142 A/C cg27246729 chr12:121163418 ACADS 0.39 6.12 0.32 2.59e-9 Urinary metabolites (H-NMR features); LUSC cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -8.39 -0.42 1.41e-15 Axial length; LUSC cis rs116095464 0.558 rs73029475 chr5:206969 T/C cg22496380 chr5:211416 CCDC127 -0.85 -8.77 -0.43 9.3e-17 Breast cancer; LUSC cis rs68170813 0.559 rs78064065 chr7:106967440 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.52 -0.46 3.62e-19 Coronary artery disease; LUSC cis rs950169 0.922 rs11638445 chr15:85137694 C/A cg17173187 chr15:85201210 NMB 0.36 6.18 0.32 1.9e-9 Schizophrenia; LUSC trans rs225245 0.817 rs1476553 chr17:33994566 C/T cg19694781 chr19:47549865 TMEM160 -0.41 -6.54 -0.34 2.28e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs62400317 0.859 rs10948220 chr6:45236654 A/G cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC trans rs11098499 0.863 rs1010740 chr4:120463409 C/T cg25214090 chr10:38739885 LOC399744 -0.52 -7.84 -0.39 6.04e-14 Corneal astigmatism; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg10963375 chr1:205815865 PM20D1 0.32 5.67 0.3 3.14e-8 Menarche (age at onset); LUSC cis rs34734847 0.842 rs696337 chr12:121159380 T/C cg27246729 chr12:121163418 ACADS 0.41 6.51 0.34 2.75e-10 Mean corpuscular volume; LUSC cis rs1965732 1.000 rs1965732 chr2:3709108 A/G cg10645314 chr2:3704589 ALLC -0.37 -6.56 -0.34 2.02e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs6456156 0.586 rs9457261 chr6:167467679 A/G cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs2932538 0.885 rs6691025 chr1:113177070 G/T cg22162597 chr1:113214053 CAPZA1 -0.7 -9.97 -0.48 1.14e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.33 0.67 1.77e-44 Platelet count; LUSC cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg05985134 chr18:33552581 C18orf21 0.53 7.26 0.37 2.74e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs10254118 0.757 rs7788086 chr7:133135206 C/T cg10665199 chr7:133106180 EXOC4 0.59 7.98 0.4 2.35e-14 Intelligence (multi-trait analysis); LUSC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg03732007 chr1:2071316 PRKCZ -0.54 -9.55 -0.46 2.89e-19 Height; LUSC cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs4604732 0.631 rs75600450 chr1:247625492 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs9329221 0.905 rs13252982 chr8:10255105 C/G cg08975724 chr8:8085496 FLJ10661 -0.5 -7.26 -0.37 2.67e-12 Neuroticism; LUSC cis rs977987 0.778 rs4888409 chr16:75436231 A/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.79e-10 Dupuytren's disease; LUSC cis rs2522056 1.000 rs757105 chr5:131795663 C/T cg24060327 chr5:131705240 SLC22A5 0.45 5.96 0.31 6.39e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg18876405 chr7:65276391 NA -0.54 -8.57 -0.42 3.82e-16 Aortic root size; LUSC cis rs694739 0.654 rs10897488 chr11:64140806 T/C cg26898376 chr11:64110657 CCDC88B 0.31 5.78 0.3 1.69e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs782590 0.774 rs782637 chr2:55894247 T/C cg03859395 chr2:55845619 SMEK2 0.88 15.88 0.66 1.07e-42 Metabolic syndrome; LUSC cis rs1570884 0.516 rs2146144 chr13:50170245 C/T cg08779649 chr13:50194554 NA 0.4 6.83 0.35 3.95e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs9611519 0.929 rs926914 chr22:41418154 C/T cg13813247 chr22:41461852 NA -0.36 -6.38 -0.33 6.06e-10 Neuroticism; LUSC cis rs4363385 0.791 rs489323 chr1:153006047 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg17420585 chr12:42539391 GXYLT1 -0.37 -7.15 -0.36 5.34e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs11264799 0.603 rs12133056 chr1:157585751 G/T cg18268488 chr1:157545234 FCRL4 0.36 6.62 0.34 1.41e-10 IgA nephropathy; LUSC cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg13010199 chr12:38710504 ALG10B 0.71 12.08 0.55 3.9e-28 Heart rate; LUSC trans rs561341 0.883 rs4450460 chr17:30201309 C/T cg27661571 chr11:113659931 NA 0.6 6.43 0.33 4.36e-10 Hip circumference adjusted for BMI; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13673779 chr18:48723081 MEX3C -0.36 -5.97 -0.31 5.9e-9 Electrocardiographic conduction measures; LUSC cis rs7621025 0.675 rs34602896 chr3:136346385 A/G cg15507776 chr3:136538369 TMEM22 -0.43 -5.8 -0.3 1.53e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.36 -6.05 -0.31 3.95e-9 Red cell distribution width;Reticulocyte count; LUSC cis rs7178572 0.568 rs11630689 chr15:77520094 C/T cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs7615316 0.779 rs9871402 chr3:142024351 A/C cg16271453 chr3:142027066 XRN1 -0.38 -6.55 -0.34 2.23e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs208520 0.690 rs2126120 chr6:66742754 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.82 0.68 2.11e-46 Exhaled nitric oxide output; LUSC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg07936489 chr17:37558343 FBXL20 0.72 9.94 0.48 1.47e-20 Glomerular filtration rate (creatinine); LUSC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg08508325 chr11:3079039 CARS -0.53 -13.35 -0.59 6.94e-33 Longevity; LUSC cis rs12701220 0.817 rs1058729 chr7:1087283 C/T cg00990874 chr7:1149470 C7orf50 -0.45 -5.87 -0.31 1.05e-8 Bronchopulmonary dysplasia; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg13047869 chr3:10149882 C3orf24 0.57 8.04 0.4 1.54e-14 Alzheimer's disease; LUSC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg14829155 chr15:31115871 NA -0.72 -10.66 -0.5 5.02e-23 Huntington's disease progression; LUSC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg17747265 chr1:1875780 NA 0.46 8.6 0.43 3.04e-16 Body mass index; LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg14196790 chr5:131705035 SLC22A5 0.43 7.17 0.37 4.76e-12 Blood metabolite levels; LUSC cis rs10489525 0.583 rs1967711 chr1:115630967 C/T cg01522456 chr1:115632236 TSPAN2 0.7 10.23 0.49 1.52e-21 Autism; LUSC cis rs7246657 0.943 rs1373991 chr19:37838911 T/C cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs13315871 0.929 rs13077539 chr3:58267846 T/C cg20936604 chr3:58311152 NA -0.75 -6.97 -0.36 1.7e-11 Cholesterol, total; LUSC cis rs7246657 0.653 rs10402050 chr19:37688958 A/T cg23950597 chr19:37808831 NA -0.62 -6.38 -0.33 5.75e-10 Coronary artery calcification; LUSC cis rs754466 1.000 rs56256440 chr10:79698207 A/G cg17075019 chr10:79541650 NA -0.63 -8.17 -0.41 6.23e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg02117656 chr17:79614917 TSPAN10 -0.3 -5.67 -0.3 3.16e-8 Eye color traits; LUSC cis rs7605378 0.567 rs717915 chr2:200714766 C/T cg23649088 chr2:200775458 C2orf69 0.77 13.69 0.6 3.59e-34 Osteoporosis; LUSC cis rs243505 0.898 rs243537 chr7:148408278 A/G cg09806900 chr7:148480153 CUL1 -0.48 -6.8 -0.35 4.74e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4285028 0.747 rs7623901 chr3:121529011 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.9 12.59 0.57 5e-30 Multiple sclerosis; LUSC trans rs9944715 1.000 rs9944836 chr18:43831380 C/T cg01718231 chr17:29326311 RNF135 0.52 7.37 0.37 1.37e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.57 -0.34 1.94e-10 Schizophrenia; LUSC cis rs7582180 0.652 rs11687865 chr2:100947000 T/A cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.679 rs1156706 chr12:39372641 G/A cg26384229 chr12:38710491 ALG10B 0.43 5.83 0.3 1.27e-8 Morning vs. evening chronotype; LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.58 0.38 3.4e-13 Bipolar disorder; LUSC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg20933634 chr6:27740509 NA 0.42 5.9 0.31 9.13e-9 Parkinson's disease; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg19747945 chr6:42946146 PEX6 -0.35 -5.68 -0.3 2.98e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1568889 0.838 rs4614434 chr11:28302234 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 13.11 0.58 5.77e-32 Bipolar disorder; LUSC cis rs7106204 1.000 rs12798139 chr11:24220907 A/G ch.11.24196551F chr11:24239977 NA 0.99 9.97 0.48 1.12e-20 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11105298 0.891 rs4842654 chr12:89834428 T/A cg00757033 chr12:89920650 WDR51B 0.59 10.15 0.49 2.74e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2302729 0.545 rs10161275 chr12:2771018 A/G cg19945202 chr12:2788847 CACNA1C -0.42 -7.17 -0.37 4.75e-12 Sleep quality; LUSC trans rs7647973 0.593 rs4855885 chr3:49690199 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -6.84 -0.35 3.85e-11 Menarche (age at onset); LUSC cis rs11676348 0.772 rs12471105 chr2:218950209 G/A cg06547715 chr2:218990976 CXCR2 0.32 6.2 0.32 1.65e-9 Ulcerative colitis; LUSC cis rs10089 1.000 rs10060181 chr5:127475573 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.89 12.43 0.56 1.98e-29 Ileal carcinoids; LUSC cis rs68170813 0.652 rs6957186 chr7:107200592 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.46 -5.72 -0.3 2.4e-8 Coronary artery disease; LUSC cis rs7100689 0.577 rs2282367 chr10:82040346 A/G cg01528321 chr10:82214614 TSPAN14 0.92 14.09 0.61 1.02e-35 Post bronchodilator FEV1; LUSC cis rs9467773 0.565 rs4343916 chr6:26522675 A/T cg09904177 chr6:26538194 HMGN4 0.57 8.91 0.44 3.43e-17 Intelligence (multi-trait analysis); LUSC cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg09035930 chr12:129282057 SLC15A4 0.6 10.22 0.49 1.65e-21 Systemic lupus erythematosus; LUSC cis rs4601821 0.858 rs4938012 chr11:113259654 A/G cg14159747 chr11:113255604 NA 0.26 6.1 0.32 2.92e-9 Alcoholic chronic pancreatitis; LUSC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg11608241 chr8:8085544 FLJ10661 0.44 6.74 0.35 7.05e-11 Mood instability; LUSC trans rs11098499 0.954 rs7436506 chr4:120393769 T/C cg25214090 chr10:38739885 LOC399744 0.6 8.81 0.43 6.84e-17 Corneal astigmatism; LUSC cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 2.02e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11098499 0.863 rs2127823 chr4:120485670 G/T cg09307838 chr4:120376055 NA 0.76 11.12 0.52 1.15e-24 Corneal astigmatism; LUSC cis rs11758351 0.587 rs16891466 chr6:26235737 G/A cg23601095 chr6:26197514 HIST1H3D 0.69 7.46 0.38 7.54e-13 Gout;Renal underexcretion gout; LUSC cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg24006582 chr15:45444508 DUOX1 -0.6 -8.67 -0.43 1.84e-16 Uric acid levels; LUSC cis rs11997175 0.603 rs716584 chr8:33779748 C/G ch.8.33884649F chr8:33765107 NA 0.42 6.29 0.33 1e-9 Body mass index; LUSC cis rs317689 0.690 rs317630 chr12:69637847 T/C cg20891283 chr12:69753455 YEATS4 0.44 5.77 0.3 1.82e-8 Response to diuretic therapy; LUSC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg15445000 chr17:37608096 MED1 -0.42 -7.14 -0.36 5.98e-12 Glomerular filtration rate (creatinine); LUSC cis rs1790761 0.607 rs656652 chr11:67343957 C/T cg23188684 chr11:67383651 NA 0.35 6.18 0.32 1.92e-9 Mean corpuscular volume; LUSC cis rs3936840 0.647 rs942024 chr14:102979463 C/T cg18135206 chr14:102964638 TECPR2 0.48 6.49 0.33 3.07e-10 Plateletcrit; LUSC cis rs11864453 0.826 rs6499559 chr16:72132064 G/C cg23815491 chr16:72088622 HP 0.34 5.97 0.31 6.12e-9 Fibrinogen levels; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg24813613 chr7:1882135 MAD1L1 -0.44 -7.31 -0.37 1.99e-12 Bipolar disorder and schizophrenia; LUSC cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg12011299 chr4:100065546 ADH4 0.69 10.36 0.49 5.28e-22 Alcohol dependence; LUSC cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC cis rs3806843 1.000 rs10073974 chr5:140165231 T/C cg26395211 chr5:140044315 WDR55 -0.37 -5.78 -0.3 1.74e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1044826 0.642 rs6771831 chr3:139177585 C/T cg15131784 chr3:139108705 COPB2 0.41 6.66 0.34 1.12e-10 Obesity-related traits; LUSC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg06484146 chr7:12443880 VWDE -0.68 -7.26 -0.37 2.76e-12 Coronary artery disease; LUSC cis rs7826238 0.524 rs2921055 chr8:8319342 C/A cg08975724 chr8:8085496 FLJ10661 0.53 8.0 0.4 2.07e-14 Systolic blood pressure; LUSC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg21681030 chr2:46777652 RHOQ 0.51 7.94 0.4 3.08e-14 Height; LUSC cis rs7582180 0.715 rs11123823 chr2:100916315 A/G cg08017756 chr2:100939284 LONRF2 -0.44 -7.8 -0.39 7.92e-14 Intelligence (multi-trait analysis); LUSC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg17173187 chr15:85201210 NMB 0.37 6.5 0.33 3e-10 Schizophrenia; LUSC cis rs62400317 0.762 rs6908606 chr6:44998888 A/G cg18551225 chr6:44695536 NA -0.42 -6.76 -0.35 6.21e-11 Total body bone mineral density; LUSC cis rs17092148 0.887 rs2144956 chr20:33145868 G/A cg16810054 chr20:33298113 TP53INP2 -0.36 -5.72 -0.3 2.31e-8 Neuroticism; LUSC cis rs9325144 0.723 rs3887436 chr12:39189526 A/C cg26384229 chr12:38710491 ALG10B -0.6 -9.2 -0.45 4.07e-18 Morning vs. evening chronotype; LUSC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg04166393 chr7:2884313 GNA12 0.43 5.74 0.3 2.14e-8 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05797538 chr16:56554066 BBS2 0.75 6.01 0.31 4.79e-9 Cognitive performance; LUSC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg14562523 chr21:43528734 C21orf128;UMODL1 -0.44 -7.28 -0.37 2.43e-12 IgG glycosylation; LUSC cis rs2854160 0.581 rs2727319 chr17:61960215 C/T cg06873352 chr17:61820015 STRADA 0.54 8.22 0.41 4.53e-15 Height; LUSC cis rs7289126 0.966 rs2284072 chr22:38633666 A/C cg25457927 chr22:38595422 NA -0.29 -5.73 -0.3 2.2e-8 Mammographic density (dense area);Percent mammographic density; LUSC cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg16339924 chr4:17578868 LAP3 0.55 8.48 0.42 7.61e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg01416388 chr22:39784598 NA -0.42 -6.94 -0.35 2.11e-11 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.76 -0.47 5.99e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs2227564 0.620 rs4746148 chr10:75534488 C/T cg23231163 chr10:75533350 FUT11 -0.46 -6.72 -0.35 7.97e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs8062405 0.723 rs62031562 chr16:28609329 A/T cg16576597 chr16:28551801 NUPR1 0.33 6.57 0.34 1.99e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs9291683 0.620 rs11722946 chr4:10125990 A/G cg26043149 chr18:55253948 FECH -0.53 -7.57 -0.38 3.74e-13 Bone mineral density; LUSC cis rs62064224 0.702 rs735555 chr17:30817450 A/G cg25809561 chr17:30822961 MYO1D -0.44 -8.25 -0.41 3.74e-15 Schizophrenia; LUSC cis rs6121246 0.647 rs6088855 chr20:30225792 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.52 -0.34 2.67e-10 Mean corpuscular hemoglobin; LUSC cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.67 -9.22 -0.45 3.46e-18 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9457247 0.565 rs55873403 chr6:167511800 C/T cg06454157 chr6:167490870 NA -0.25 -5.71 -0.3 2.52e-8 Crohn's disease; LUSC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg02018176 chr4:1364513 KIAA1530 0.45 7.42 0.38 9.56e-13 Obesity-related traits; LUSC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg12310025 chr6:25882481 NA -0.41 -7.28 -0.37 2.43e-12 Height; LUSC cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.65 8.33 0.41 2.1e-15 Lung function (FEV1/FVC); LUSC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg08975724 chr8:8085496 FLJ10661 0.47 7.05 0.36 1.01e-11 Mood instability; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16755220 chr16:12070685 RUNDC2A -0.46 -6.4 -0.33 5.27e-10 Bipolar disorder and schizophrenia; LUSC cis rs61931739 0.500 rs34167298 chr12:34534338 G/A cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC trans rs7980799 0.682 rs7303356 chr12:33633599 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.83 -0.39 6.54e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg09263875 chr16:632152 PIGQ 0.69 13.09 0.58 6.74e-32 Height; LUSC cis rs11098499 0.909 rs73842633 chr4:120375464 G/A cg09307838 chr4:120376055 NA 0.76 10.54 0.5 1.33e-22 Corneal astigmatism; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg20364735 chr6:13615554 NOL7 0.4 6.1 0.32 2.9e-9 Schizophrenia (age at onset); LUSC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.15e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs12980942 0.810 rs16958999 chr19:41825186 A/G cg25627403 chr19:41769009 HNRNPUL1 0.56 6.08 0.32 3.22e-9 Coronary artery disease; LUSC cis rs68170813 0.559 rs76843318 chr7:106863173 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs73206853 0.841 rs55864430 chr12:110932355 G/T cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00934597 chr7:893267 UNC84A -0.48 -7.15 -0.36 5.64e-12 Perceived unattractiveness to mosquitoes; LUSC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg17376030 chr22:41985996 PMM1 -0.46 -5.88 -0.31 1.02e-8 Vitiligo; LUSC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg14552801 chr7:65878734 NA -0.45 -6.51 -0.34 2.77e-10 Aortic root size; LUSC cis rs7246967 0.611 rs7250285 chr19:22837108 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs548987 0.507 rs3757132 chr6:25832691 C/T cg03517284 chr6:25882590 NA -0.38 -5.7 -0.3 2.62e-8 Homocysteine levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22728371 chr5:32313149 MTMR12 -0.53 -6.49 -0.33 3.07e-10 Bipolar disorder and schizophrenia; LUSC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.65 14.25 0.61 2.45e-36 Hemoglobin concentration; LUSC cis rs7267979 1.000 rs2482919 chr20:25299756 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.73 -0.7 4.95e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9283706 0.608 rs71626484 chr5:66334502 A/T cg11590213 chr5:66331682 MAST4 0.44 6.42 0.33 4.75e-10 Coronary artery disease; LUSC cis rs6541297 0.645 rs2103827 chr1:230298285 T/A cg05784532 chr1:230284198 GALNT2 0.55 6.56 0.34 2.1e-10 Coronary artery disease; LUSC cis rs981844 0.735 rs17371573 chr4:154765216 G/A cg14289246 chr4:154710475 SFRP2 0.51 6.83 0.35 4.02e-11 Response to statins (LDL cholesterol change); LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.35 0.53 1.8e-25 Alzheimer's disease; LUSC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg08742575 chr21:47604166 C21orf56 0.39 5.74 0.3 2.12e-8 Testicular germ cell tumor; LUSC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg02187348 chr16:89574699 SPG7 0.46 7.11 0.36 7.08e-12 Multiple myeloma (IgH translocation); LUSC cis rs2354432 0.607 rs1530335 chr1:146685288 T/C cg25205988 chr1:146714368 CHD1L 1.08 8.58 0.42 3.65e-16 Mitochondrial DNA levels; LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg08677398 chr8:58056175 NA 0.44 6.36 0.33 6.82e-10 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03041860 chr2:208489911 FAM119A 0.45 6.73 0.35 7.2e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6599077 0.642 rs2257066 chr3:40087981 G/T cg13683864 chr3:40499215 RPL14 -0.44 -6.41 -0.33 4.88e-10 Sleep-related phenotypes; LUSC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg17077180 chr1:38461687 NA -0.45 -6.55 -0.34 2.14e-10 Coronary artery disease; LUSC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.31 0.53 2.45e-25 Menopause (age at onset); LUSC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg15147215 chr3:52552868 STAB1 -0.36 -7.11 -0.36 6.89e-12 Bipolar disorder; LUSC trans rs1486139 1.000 rs4286853 chr7:46284924 A/G cg17534202 chr9:96721102 NA -0.36 -6.48 -0.33 3.3e-10 Select biomarker traits; LUSC cis rs2130392 0.926 rs10428357 chr4:185636217 T/A cg21366198 chr4:185655624 MLF1IP -0.46 -6.59 -0.34 1.72e-10 Kawasaki disease; LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.1 -0.58 6.15e-32 Platelet count; LUSC cis rs12618769 0.652 rs4851144 chr2:99220707 T/C cg10123293 chr2:99228465 UNC50 0.47 7.71 0.39 1.48e-13 Bipolar disorder; LUSC cis rs907683 0.635 rs11691617 chr2:220295167 C/T cg15015639 chr2:220282977 DES 0.3 7.18 0.37 4.59e-12 Resting heart rate; LUSC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg12463550 chr7:65579703 CRCP -0.52 -7.54 -0.38 4.43e-13 Aortic root size; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg27535305 chr1:53392650 SCP2 -0.4 -7.57 -0.38 3.57e-13 Monocyte count; LUSC cis rs11711311 0.911 rs13321446 chr3:113522544 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.53 0.34 2.4e-10 IgG glycosylation; LUSC cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg15556689 chr8:8085844 FLJ10661 0.69 11.71 0.54 9.3e-27 Mood instability; LUSC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg05082376 chr22:42548792 NA 0.43 6.53 0.34 2.43e-10 Schizophrenia; LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg10802521 chr3:52805072 NEK4 -0.5 -7.95 -0.4 3e-14 Electroencephalogram traits; LUSC trans rs11700980 1.000 rs56288550 chr21:30131840 T/C cg05609335 chr17:75789393 NA 0.42 6.36 0.33 6.45e-10 QRS complex (12-leadsum); LUSC cis rs6977660 0.714 rs6954046 chr7:19820388 G/A cg07541023 chr7:19748670 TWISTNB 0.58 6.32 0.33 8.51e-10 Thyroid stimulating hormone; LUSC cis rs73206853 0.764 rs7953794 chr12:111081197 A/G cg12870014 chr12:110450643 ANKRD13A 0.71 8.17 0.41 6.43e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs427941 0.703 rs201440 chr7:101735599 C/T cg06246474 chr7:101738831 CUX1 0.41 6.7 0.34 8.72e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs612683 0.735 rs3754131 chr1:100931073 A/C cg09408571 chr1:101003634 GPR88 0.31 5.78 0.3 1.72e-8 Breast cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13040021 chr20:5093911 C20orf30 0.47 6.53 0.34 2.39e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10744422 0.748 rs1671688 chr12:123255733 A/T cg25930673 chr12:123319894 HIP1R -0.58 -5.96 -0.31 6.41e-9 Schizophrenia; LUSC cis rs6754311 0.773 rs309130 chr2:136631031 C/A cg07169764 chr2:136633963 MCM6 -0.57 -7.67 -0.39 1.95e-13 Mosquito bite size; LUSC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg23711669 chr6:146136114 FBXO30 0.89 17.09 0.68 1.7e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg04369109 chr6:150039330 LATS1 -0.56 -8.2 -0.41 5.13e-15 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14280377 chr14:39639762 TRAPPC6B -0.42 -6.26 -0.32 1.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12541635 0.677 rs34872724 chr8:107033071 C/T cg10147462 chr8:107024639 NA -0.68 -14.17 -0.61 5.19e-36 Age of smoking initiation; LUSC cis rs10489202 0.632 rs12410730 chr1:168069477 T/C cg24449463 chr1:168025552 DCAF6 -0.69 -10.43 -0.5 3.05e-22 Schizophrenia; LUSC cis rs722599 0.748 rs11623342 chr14:75347937 A/C cg06637938 chr14:75390232 RPS6KL1 -0.41 -5.92 -0.31 8.12e-9 IgG glycosylation; LUSC cis rs7937682 1.000 rs2186839 chr11:111534442 T/G cg09085632 chr11:111637200 PPP2R1B -1.1 -17.5 -0.69 3.98e-49 Primary sclerosing cholangitis; LUSC cis rs1775715 0.707 rs2808079 chr10:32167385 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.78 0.35 5.33e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1448094 0.872 rs10863147 chr12:86408441 G/C cg00310523 chr12:86230176 RASSF9 0.37 6.69 0.34 9.54e-11 Major depressive disorder; LUSC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg10883421 chr6:151773342 RMND1;C6orf211 -0.68 -11.77 -0.54 5.42e-27 Menarche (age at onset); LUSC cis rs6120849 0.754 rs6087667 chr20:33651887 A/G cg24642439 chr20:33292090 TP53INP2 0.6 6.63 0.34 1.35e-10 Protein C levels; LUSC cis rs9393777 1.000 rs9393777 chr6:26942027 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.46 -5.69 -0.3 2.79e-8 Intelligence (multi-trait analysis); LUSC cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg23093090 chr10:104574429 C10orf26 0.35 6.47 0.33 3.5e-10 Arsenic metabolism; LUSC cis rs1867631 0.565 rs10749764 chr1:67149706 G/C cg02459107 chr1:67143332 SGIP1 0.34 5.84 0.3 1.25e-8 Menopause (age at onset); LUSC trans rs61931739 0.534 rs12371021 chr12:34062252 T/C cg26384229 chr12:38710491 ALG10B 0.73 11.47 0.53 6.77e-26 Morning vs. evening chronotype; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10141938 chr7:26240087 HNRNPA2B1;CBX3 0.44 6.51 0.34 2.72e-10 Triglycerides; LUSC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg07636037 chr3:49044803 WDR6 0.59 6.25 0.32 1.28e-9 Menarche (age at onset); LUSC cis rs6840360 0.615 rs58977077 chr4:152470239 T/G cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs9467773 1.000 rs10484442 chr6:26555879 A/G cg05738196 chr6:26577821 NA 0.83 15.96 0.66 4.91e-43 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.62 6.36 0.33 6.63e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs16866061 0.517 rs7594223 chr2:225472985 T/C cg12698349 chr2:225449008 CUL3 0.49 7.27 0.37 2.62e-12 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg20988073 chr3:125900093 ALDH1L1 -0.33 -6.56 -0.34 2.08e-10 Metabolite levels; LUSC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 9.86 0.47 2.73e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs367943 1.000 rs2248930 chr5:112811119 G/T cg12552261 chr5:112820674 MCC -0.43 -6.95 -0.36 1.98e-11 Type 2 diabetes; LUSC trans rs11992162 0.967 rs7461062 chr8:11831948 T/C cg15556689 chr8:8085844 FLJ10661 0.58 8.32 0.41 2.33e-15 Monocyte count; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.36 0.46 1.17e-18 Prudent dietary pattern; LUSC cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg15103426 chr22:29168792 CCDC117 0.46 6.03 0.31 4.39e-9 Lymphocyte counts; LUSC cis rs61931739 0.517 rs11612493 chr12:34114272 A/C cg06521331 chr12:34319734 NA -0.46 -7.59 -0.38 3.33e-13 Morning vs. evening chronotype; LUSC cis rs7172677 0.768 rs72730587 chr15:75358053 A/G cg14664628 chr15:75095509 CSK 0.47 6.25 0.32 1.28e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9346649 0.616 rs7740995 chr6:168492221 G/A cg02770688 chr6:168491649 NA 0.51 9.71 0.47 8.45e-20 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs7712401 0.601 rs246322 chr5:122307269 C/T cg19077854 chr5:122220652 SNX24 -0.42 -9.65 -0.47 1.3e-19 Mean platelet volume; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.71 11.86 0.54 2.68e-27 Prudent dietary pattern; LUSC cis rs10097731 0.908 rs77317991 chr8:82032468 C/T cg25230327 chr8:82042993 NA -0.45 -6.61 -0.34 1.57e-10 Serum total protein level; LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg03909863 chr11:638404 DRD4 -0.41 -6.19 -0.32 1.81e-9 Systemic lupus erythematosus; LUSC cis rs7746199 0.736 rs58616630 chr6:27474715 A/G cg26958806 chr6:27640298 NA 0.8 6.56 0.34 2.04e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg19244751 chr21:35747585 FAM165B -0.48 -6.53 -0.34 2.44e-10 Hepatitis; LUSC cis rs9318086 0.663 rs2312295 chr13:24457744 A/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.45 6.79 0.35 5.02e-11 Myopia (pathological); LUSC cis rs6424115 0.618 rs10917420 chr1:24062987 C/T cg15997130 chr1:24165203 NA 0.39 6.33 0.33 7.97e-10 Immature fraction of reticulocytes; LUSC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg16060761 chr17:80687452 NA -0.42 -6.56 -0.34 2.05e-10 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08105748 chr6:57086875 RAB23 -0.44 -6.67 -0.34 1.05e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9902453 0.967 rs8072664 chr17:28333385 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.29 -0.41 2.71e-15 Coffee consumption (cups per day); LUSC cis rs1886644 1.000 rs1886644 chr1:85350658 A/C cg08479277 chr1:85350632 LPAR3 0.52 8.22 0.41 4.58e-15 Glucose homeostasis traits; LUSC cis rs7312933 0.584 rs6582391 chr12:42634686 G/A cg01256987 chr12:42539512 GXYLT1 -0.42 -7.81 -0.39 7.43e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs61931739 0.963 rs12310956 chr12:33970682 A/G cg26384229 chr12:38710491 ALG10B -0.48 -6.98 -0.36 1.63e-11 Morning vs. evening chronotype; LUSC cis rs7520050 0.807 rs12025621 chr1:46228391 G/A cg24296786 chr1:45957014 TESK2 0.41 5.84 0.3 1.25e-8 Red blood cell count;Reticulocyte count; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg26354017 chr1:205819088 PM20D1 0.53 8.65 0.43 2.2e-16 Menarche (age at onset); LUSC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg04450456 chr4:17643702 FAM184B 0.4 6.91 0.35 2.53e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8028313 0.731 rs4331293 chr15:67987801 A/G cg24579218 chr15:68104479 NA -0.36 -6.19 -0.32 1.74e-9 Obesity; LUSC cis rs911555 0.546 rs28798508 chr14:104068970 T/C cg24130564 chr14:104152367 KLC1 -0.71 -11.28 -0.53 3.13e-25 Intelligence (multi-trait analysis); LUSC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg13114125 chr14:105738426 BRF1 -0.92 -16.14 -0.66 1.01e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs9814567 0.964 rs9847788 chr3:134186496 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.24 -0.56 1.05e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.24e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6599077 0.802 rs11720413 chr3:40141857 C/G cg13683864 chr3:40499215 RPL14 -0.53 -7.08 -0.36 8.41e-12 Sleep-related phenotypes; LUSC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg14829155 chr15:31115871 NA -0.72 -10.7 -0.51 3.74e-23 Huntington's disease progression; LUSC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg26695010 chr11:65641043 EFEMP2 0.41 5.74 0.3 2.14e-8 Breast cancer; LUSC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg06221963 chr1:154839813 KCNN3 -0.67 -16.23 -0.66 4.39e-44 Prostate cancer; LUSC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.68 0.5 4.16e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs4808199 0.895 rs12981405 chr19:19651577 C/T cg03709012 chr19:19516395 GATAD2A 1.05 13.04 0.58 1.07e-31 Nonalcoholic fatty liver disease; LUSC cis rs7819412 0.775 rs4841490 chr8:10936891 T/C cg21775007 chr8:11205619 TDH -0.52 -7.56 -0.38 3.9e-13 Triglycerides; LUSC trans rs4332037 0.950 rs62442895 chr7:1936938 G/A cg25206134 chr2:45395956 NA 0.57 6.55 0.34 2.14e-10 Bipolar disorder; LUSC trans rs11992162 0.967 rs4840601 chr8:11828730 G/C cg15556689 chr8:8085844 FLJ10661 0.55 8.15 0.41 7.29e-15 Monocyte count; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.43 -6.51 -0.34 2.75e-10 Prudent dietary pattern; LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg24060327 chr5:131705240 SLC22A5 -0.67 -11.71 -0.54 8.72e-27 Blood metabolite levels; LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.49 -0.38 6.39e-13 Lymphocyte counts; LUSC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg23281280 chr6:28129359 ZNF389 0.45 6.04 0.31 4.09e-9 Parkinson's disease; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg10699731 chr19:12780957 C19orf56;MORG1 0.37 6.01 0.31 4.98e-9 Mosquito bite size; LUSC trans rs2736337 0.530 rs2003422 chr8:11303137 G/C cg15556689 chr8:8085844 FLJ10661 0.43 6.07 0.32 3.41e-9 Rheumatoid arthritis; LUSC trans rs1005277 0.540 rs1814077 chr10:37992018 G/C cg17830980 chr10:43048298 ZNF37B -0.42 -6.69 -0.34 9.2e-11 Extrinsic epigenetic age acceleration; LUSC cis rs79349575 0.679 rs9894239 chr17:46997959 C/T cg22482690 chr17:47019901 SNF8 -0.34 -6.13 -0.32 2.51e-9 Type 2 diabetes; LUSC cis rs57590327 0.716 rs3772891 chr3:81776760 A/G cg07356753 chr3:81810745 GBE1 0.62 8.56 0.42 4.3e-16 Extraversion; LUSC cis rs12681288 0.644 rs2123058 chr8:1000304 A/G cg15309053 chr8:964076 NA 0.38 7.85 0.39 5.78e-14 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12753558 chr1:247464072 ZNF496 0.45 6.07 0.32 3.56e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7192380 0.639 rs2917666 chr16:69763960 C/G cg00738113 chr16:70207722 CLEC18C 0.31 6.28 0.33 1.04e-9 Sjögren's syndrome; LUSC cis rs7647973 1.000 rs9842132 chr3:49427933 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.46 -6.99 -0.36 1.53e-11 Menarche (age at onset); LUSC cis rs6500602 0.634 rs2270365 chr16:4526758 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.52 6.88 0.35 3.05e-11 Schizophrenia; LUSC cis rs78572108 0.858 rs61473148 chr2:42259707 C/A cg00607755 chr2:42274082 PKDCC 0.37 6.55 0.34 2.13e-10 Total body bone mineral density; LUSC trans rs6957923 0.655 rs6949019 chr7:23594050 A/G ch.2.47844995F chr2:47991493 NA 0.38 6.24 0.32 1.35e-9 Height; LUSC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg04844267 chr4:1394941 NA 0.33 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs3741151 0.773 rs73543000 chr11:73151774 T/C cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7223966 1.000 rs7209758 chr17:61913621 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.74 0.35 6.78e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9467773 0.595 rs6907924 chr6:26438817 T/G cg05738196 chr6:26577821 NA -0.52 -7.72 -0.39 1.37e-13 Intelligence (multi-trait analysis); LUSC cis rs6545883 0.929 rs10190332 chr2:61619267 T/G cg15711740 chr2:61764176 XPO1 0.42 6.53 0.34 2.43e-10 Tuberculosis; LUSC trans rs17039065 1.000 rs17039068 chr4:109385975 C/A cg07444054 chr2:108107501 NA 0.41 6.12 0.32 2.59e-9 Gut microbiome composition (summer); LUSC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg08677398 chr8:58056175 NA 0.55 6.95 0.36 1.94e-11 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg02018176 chr4:1364513 KIAA1530 0.55 9.75 0.47 6.15e-20 Obesity-related traits; LUSC cis rs9399401 0.667 rs7757571 chr6:142702589 A/C cg03128060 chr6:142623767 GPR126 0.61 9.98 0.48 1.1e-20 Chronic obstructive pulmonary disease; LUSC cis rs3931020 0.671 rs1327088 chr1:75255491 A/G cg10128416 chr1:75198403 TYW3;CRYZ 0.48 7.56 0.38 4.03e-13 Resistin levels; LUSC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg22535103 chr8:58192502 C8orf71 -0.8 -9.77 -0.47 5.27e-20 Developmental language disorder (linguistic errors); LUSC cis rs1595825 0.786 rs74652956 chr2:198754247 C/T cg00982548 chr2:198649783 BOLL -0.56 -7.02 -0.36 1.24e-11 Ulcerative colitis; LUSC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.47 7.76 0.39 1.06e-13 Vitiligo; LUSC cis rs7799006 0.755 rs2256545 chr7:2291943 G/A cg08027265 chr7:2291960 NA -0.64 -11.65 -0.54 1.45e-26 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3824867 0.920 rs7101772 chr11:47449378 A/G cg20307385 chr11:47447363 PSMC3 -0.64 -9.52 -0.46 3.67e-19 Mean corpuscular hemoglobin; LUSC cis rs56104184 0.830 rs28556985 chr19:49351149 C/T cg15549821 chr19:49342101 PLEKHA4 -0.88 -10.38 -0.49 4.65e-22 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs1997103 1.000 rs6966183 chr7:55407546 A/C cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg26384229 chr12:38710491 ALG10B 0.85 13.97 0.61 2.94e-35 Bladder cancer; LUSC cis rs2303282 0.716 rs2587872 chr16:56412696 T/C cg00500540 chr16:56394104 NA -0.44 -7.69 -0.39 1.7e-13 Breast cancer; LUSC cis rs6066835 1.000 rs742645 chr20:47323655 G/A cg18078177 chr20:47281410 PREX1 0.75 6.1 0.32 2.87e-9 Multiple myeloma; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg00166722 chr3:10149974 C3orf24 0.53 7.36 0.37 1.41e-12 Alzheimer's disease; LUSC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg06640241 chr16:89574553 SPG7 0.89 16.11 0.66 1.28e-43 Multiple myeloma (IgH translocation); LUSC cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg15423357 chr2:25149977 NA 0.45 9.03 0.44 1.37e-17 Body mass index in non-asthmatics; LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.54 0.34 2.28e-10 Bipolar disorder; LUSC cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg21535247 chr6:8435926 SLC35B3 0.58 8.99 0.44 1.87e-17 Motion sickness; LUSC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg06582575 chr6:163149167 PACRG;PARK2 1.11 14.54 0.62 1.83e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.5e-24 Aortic root size; LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg02018176 chr4:1364513 KIAA1530 -0.72 -12.94 -0.58 2.63e-31 Longevity; LUSC cis rs55871839 0.619 rs6471756 chr8:59802159 A/G cg07426533 chr8:59803705 TOX -0.36 -5.75 -0.3 2.07e-8 Pneumonia; LUSC cis rs12540874 0.965 rs9791887 chr7:50661170 A/C cg18232548 chr7:50535776 DDC -0.43 -6.02 -0.31 4.5e-9 Systemic sclerosis; LUSC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.72 0.47 7.61e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7824557 0.564 rs2736294 chr8:11234626 T/C cg21775007 chr8:11205619 TDH -0.65 -10.2 -0.49 1.94e-21 Retinal vascular caliber; LUSC cis rs9560113 0.959 rs9555803 chr13:112179560 G/T cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.54e-13 Menarche (age at onset); LUSC trans rs7824557 0.564 rs2736302 chr8:11236419 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.83 -0.39 6.41e-14 Retinal vascular caliber; LUSC cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.66 -0.43 2.03e-16 Body mass index; LUSC cis rs7772486 0.875 rs10872582 chr6:146373061 G/A cg05347473 chr6:146136440 FBXO30 0.51 8.53 0.42 5.03e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7100689 0.622 rs10736344 chr10:82133955 T/C cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.02 -0.31 4.68e-9 Major depressive disorder; LUSC cis rs9486719 0.895 rs3734238 chr6:96996228 A/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.74 -0.47 6.99e-20 Migraine;Coronary artery disease; LUSC cis rs3768617 0.510 rs2296292 chr1:183086757 A/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs4808199 0.649 rs34755166 chr19:19665581 G/A cg03709012 chr19:19516395 GATAD2A 0.91 10.03 0.48 7.4e-21 Nonalcoholic fatty liver disease; LUSC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.66 -0.43 2.1e-16 Lung cancer; LUSC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11890956 chr21:40555474 PSMG1 -0.71 -11.09 -0.52 1.47e-24 Menarche (age at onset); LUSC cis rs2688608 0.901 rs2675671 chr10:75632760 C/T cg23231163 chr10:75533350 FUT11 -0.38 -6.13 -0.32 2.44e-9 Inflammatory bowel disease; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg08399230 chr16:4665037 FAM100A 0.35 5.96 0.31 6.57e-9 Schizophrenia (age at onset); LUSC cis rs722599 0.748 rs1059326 chr14:75369385 C/T cg08847533 chr14:75593920 NEK9 -0.49 -7.09 -0.36 7.96e-12 IgG glycosylation; LUSC cis rs7584330 0.554 rs3751111 chr2:238426953 G/T cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC cis rs62400317 0.859 rs10456122 chr6:45163057 C/G cg20913747 chr6:44695427 NA -0.48 -7.67 -0.39 1.91e-13 Total body bone mineral density; LUSC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg08109568 chr15:31115862 NA 0.73 11.12 0.52 1.2e-24 Huntington's disease progression; LUSC cis rs4595586 0.545 rs6580894 chr12:39371951 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.12 0.36 6.78e-12 Morning vs. evening chronotype; LUSC cis rs9815354 0.761 rs17280777 chr3:41806167 C/T cg03022575 chr3:42003672 ULK4 0.83 8.52 0.42 5.39e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs12541335 0.603 rs9792127 chr8:22180334 G/A cg09517075 chr8:22133004 PIWIL2 0.41 8.16 0.41 6.69e-15 Hypertriglyceridemia; LUSC cis rs644799 0.648 rs1255181 chr11:95472148 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.31 0.33 8.94e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3772130 0.962 rs1318472 chr3:121556899 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.68 10.0 0.48 9e-21 Cognitive performance; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03552398 chr14:89021307 PTPN21 0.41 6.07 0.32 3.46e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.06 0.52 1.99e-24 Prudent dietary pattern; LUSC cis rs11645898 1.000 rs72791115 chr16:72207315 T/C cg14768367 chr16:72042858 DHODH -0.63 -7.0 -0.36 1.38e-11 Blood protein levels; LUSC cis rs9733 0.650 rs61820165 chr1:150555987 C/T cg09365446 chr1:150670422 GOLPH3L -0.41 -5.94 -0.31 7.13e-9 Tonsillectomy; LUSC cis rs3931020 0.688 rs525487 chr1:75217420 A/G cg21906852 chr1:75198582 TYW3;CRYZ -0.44 -5.71 -0.3 2.5e-8 Resistin levels; LUSC cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.5 -5.74 -0.3 2.15e-8 Schizophrenia; LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg21280719 chr6:42927975 GNMT -0.34 -8.51 -0.42 5.99e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg03060546 chr3:49711283 APEH 0.7 11.67 0.54 1.23e-26 Resting heart rate; LUSC trans rs7824557 0.527 rs2572448 chr8:11239352 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.84 -0.35 3.69e-11 Retinal vascular caliber; LUSC cis rs3862030 0.836 rs12771867 chr10:104246691 G/A cg22532475 chr10:104410764 TRIM8 0.25 5.95 0.31 6.71e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7759001 0.857 rs980962 chr6:27361008 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.77e-8 Glomerular filtration rate (creatinine); LUSC cis rs11098499 0.909 rs10002083 chr4:120311152 C/T cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg18099408 chr3:52552593 STAB1 0.37 6.2 0.32 1.63e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs17125944 0.505 rs2274275 chr14:53235728 G/T cg00686598 chr14:53173677 PSMC6 1.15 10.47 0.5 2.35e-22 Alzheimer's disease (late onset); LUSC cis rs9309473 0.718 rs6546829 chr2:73613789 C/G cg20560298 chr2:73613845 ALMS1 -0.62 -9.47 -0.46 5.11e-19 Metabolite levels; LUSC cis rs7572644 0.662 rs6706209 chr2:28101938 C/T cg27432699 chr2:27873401 GPN1 -0.49 -6.58 -0.34 1.85e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg12292205 chr6:26970375 C6orf41 -0.51 -8.48 -0.42 7.18e-16 Schizophrenia; LUSC cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg13319975 chr6:146136371 FBXO30 0.48 7.31 0.37 1.99e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs709400 0.663 rs17617941 chr14:103953032 T/C cg24130564 chr14:104152367 KLC1 -0.41 -5.75 -0.3 1.98e-8 Body mass index; LUSC cis rs1979679 0.573 rs6487694 chr12:28727734 T/C cg13890972 chr12:28721907 NA -0.4 -5.86 -0.31 1.09e-8 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg03433033 chr1:76189801 ACADM -0.48 -7.14 -0.36 5.8e-12 Daytime sleep phenotypes; LUSC cis rs7178572 0.568 rs1493700 chr15:77629060 T/C cg22256960 chr15:77711686 NA -0.5 -8.04 -0.4 1.57e-14 Type 2 diabetes; LUSC cis rs7267979 0.789 rs2260197 chr20:25284343 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.75 15.04 0.64 2.08e-39 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9929218 0.954 rs35444713 chr16:68824492 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.09 -0.52 1.54e-24 Colorectal cancer; LUSC cis rs3741151 0.892 rs2027763 chr11:73035799 A/G cg17517138 chr11:73019481 ARHGEF17 0.83 7.98 0.4 2.35e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1113500 0.933 rs10881498 chr1:108634984 C/A cg11967332 chr1:108735228 SLC25A24 0.39 5.92 0.31 7.86e-9 Growth-regulated protein alpha levels; LUSC cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg13010199 chr12:38710504 ALG10B 0.62 9.48 0.46 4.72e-19 Bladder cancer; LUSC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg25251562 chr2:3704773 ALLC -0.49 -7.44 -0.38 8.43e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7267979 0.844 rs6083851 chr20:25401235 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -16.35 -0.67 1.41e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg09835421 chr16:68378352 PRMT7 -0.54 -6.08 -0.32 3.32e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2836633 0.929 rs62217517 chr21:40033177 T/A cg05519781 chr21:40033154 ERG 0.77 13.32 0.59 9.59e-33 Coronary artery disease; LUSC cis rs1775715 0.737 rs11008695 chr10:32216887 T/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.52e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs250677 0.522 rs10038913 chr5:148354224 A/G cg12140854 chr5:148520817 ABLIM3 0.36 5.99 0.31 5.57e-9 Breast cancer; LUSC cis rs1865721 0.804 rs3826652 chr18:73142153 C/T cg26385618 chr18:73139727 C18orf62 0.54 10.6 0.5 8.3300000000000006e-23 Intelligence; LUSC cis rs4363385 0.720 rs1970328 chr1:152975829 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg24675658 chr1:53192096 ZYG11B -0.53 -8.33 -0.41 2.18e-15 Monocyte count; LUSC cis rs7113850 0.541 rs4536215 chr11:24245374 C/A ch.11.24196551F chr11:24239977 NA 1.01 9.09 0.45 9.05e-18 Bone fracture in osteoporosis; LUSC cis rs4974559 0.739 rs3817604 chr4:1291337 C/T cg02980000 chr4:1222292 CTBP1 1.02 9.13 0.45 6.93e-18 Systolic blood pressure; LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg07395648 chr5:131743802 NA -0.39 -5.8 -0.3 1.53e-8 Breast cancer; LUSC cis rs2282300 0.739 rs1222219 chr11:30344345 G/C cg25418670 chr11:30344373 C11orf46 -0.65 -9.25 -0.45 2.7e-18 Morning vs. evening chronotype; LUSC cis rs10489525 0.599 rs2335724 chr1:115608444 T/C cg17147537 chr1:115611705 TSPAN2 0.3 6.08 0.32 3.36e-9 Autism; LUSC cis rs9677476 0.818 rs16827879 chr2:232092301 C/T cg07929768 chr2:232055508 NA 0.34 6.4 0.33 5.36e-10 Food antigen IgG levels; LUSC cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.03 0.48 6.98e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 9.88 0.48 2.32e-20 Menopause (age at onset); LUSC cis rs2204008 0.547 rs12318267 chr12:38250905 T/G cg13010199 chr12:38710504 ALG10B -0.46 -7.01 -0.36 1.35e-11 Bladder cancer; LUSC cis rs1557765 0.527 rs10832782 chr11:17397273 G/C cg15432903 chr11:17409602 KCNJ11 0.46 7.86 0.4 5.27e-14 Body mass index;Social communication problems; LUSC cis rs6580649 0.943 rs1990029 chr12:48407987 C/T cg24011408 chr12:48396354 COL2A1 0.51 6.87 0.35 3.21e-11 Lung cancer; LUSC cis rs72781680 1.000 rs56205282 chr2:24221317 C/T cg08917208 chr2:24149416 ATAD2B 1.0 10.55 0.5 1.22e-22 Lymphocyte counts; LUSC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg11871910 chr12:69753446 YEATS4 0.64 9.3 0.45 1.88e-18 Cerebrospinal fluid biomarker levels; LUSC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.55 7.97 0.4 2.51e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg09323728 chr8:95962352 TP53INP1 -0.45 -9.33 -0.45 1.46e-18 Type 2 diabetes; LUSC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg04362960 chr10:104952993 NT5C2 0.57 8.22 0.41 4.65e-15 Arsenic metabolism; LUSC trans rs61931739 0.517 rs11513277 chr12:34074799 G/T cg13010199 chr12:38710504 ALG10B 0.56 8.51 0.42 5.98e-16 Morning vs. evening chronotype; LUSC trans rs1493916 0.870 rs7239173 chr18:31395534 A/T cg15819921 chr19:927150 ARID3A -0.43 -6.36 -0.33 6.54e-10 Life satisfaction; LUSC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs2742417 1.000 rs2673034 chr3:45755138 A/G cg18779283 chr3:45636154 LIMD1 -0.34 -5.9 -0.31 8.79e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7605827 0.930 rs11676115 chr2:15602962 G/A cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs10072221 0.836 rs55995866 chr5:75701344 A/G cg03132911 chr5:75698732 IQGAP2 0.38 6.44 0.33 4.25e-10 Mean platelet volume; LUSC cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.31 0.37 1.99e-12 Motion sickness; LUSC trans rs8072100 0.701 rs10163469 chr17:45687767 G/A cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.18e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg09021430 chr5:549028 NA -0.55 -7.57 -0.38 3.64e-13 Obesity-related traits; LUSC cis rs76878669 0.561 rs10791872 chr11:66138434 C/G cg18002602 chr11:66138449 SLC29A2 -0.48 -8.45 -0.42 9.19e-16 Educational attainment (years of education); LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg00166722 chr3:10149974 C3orf24 -0.59 -8.45 -0.42 8.98e-16 Alzheimer's disease; LUSC cis rs1178968 1.000 rs4717755 chr7:72761178 T/G cg25889504 chr7:72793014 NA 0.52 6.79 0.35 5.28e-11 Triglyceride levels; LUSC cis rs2346177 0.875 rs1447565 chr2:46643682 T/A cg02822958 chr2:46747628 ATP6V1E2 0.37 6.27 0.32 1.11e-9 HDL cholesterol; LUSC cis rs6674176 0.932 rs7412307 chr1:44433864 C/G cg15962314 chr1:44399869 ARTN -0.29 -6.35 -0.33 6.95e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7666738 0.515 rs10015315 chr4:98700137 A/G cg05340658 chr4:99064831 C4orf37 0.59 8.75 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs7568458 0.846 rs1078004 chr2:85769711 C/G cg02493740 chr2:85810744 VAMP5 -0.37 -6.51 -0.34 2.73e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg01475377 chr6:109611718 NA -0.43 -7.78 -0.39 8.93e-14 Reticulocyte fraction of red cells; LUSC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg07701084 chr6:150067640 NUP43 0.58 8.97 0.44 2.22e-17 Lung cancer; LUSC cis rs2835872 0.793 rs2835835 chr21:38989072 G/A cg20424643 chr21:39039972 KCNJ6 0.36 5.69 0.3 2.84e-8 Electroencephalographic traits in alcoholism; LUSC trans rs13196614 0.697 rs35007635 chr6:149021587 T/C cg01343097 chr1:248284971 OR2M1P 0.41 5.96 0.31 6.57e-9 Migraine; LUSC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.55 0.34 2.22e-10 Schizophrenia; LUSC cis rs11098499 0.820 rs28578366 chr4:120536905 A/G cg24375607 chr4:120327624 NA -0.7 -10.98 -0.51 3.79e-24 Corneal astigmatism; LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg15335117 chr5:41925216 FBXO4 0.37 6.08 0.32 3.35e-9 Breast cancer; LUSC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg25019033 chr10:957182 NA -0.51 -6.35 -0.33 7.22e-10 Eosinophil percentage of granulocytes; LUSC cis rs250677 0.522 rs10040598 chr5:148365720 C/A cg18129178 chr5:148520854 ABLIM3 0.54 7.6 0.38 3.07e-13 Breast cancer; LUSC cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs9549367 0.713 rs576463 chr13:113846614 C/T cg18105134 chr13:113819100 PROZ 0.65 9.62 0.47 1.67e-19 Platelet distribution width; LUSC cis rs7799006 0.606 rs12535174 chr7:2310974 C/T cg08027265 chr7:2291960 NA -0.62 -10.99 -0.52 3.33e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg02487422 chr3:49467188 NICN1 0.43 6.82 0.35 4.32e-11 Resting heart rate; LUSC cis rs9399137 0.507 rs7772031 chr6:135259734 G/A cg24558204 chr6:135376177 HBS1L -0.63 -9.07 -0.44 1.03e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg00579200 chr11:133705235 NA -0.41 -5.93 -0.31 7.69e-9 Childhood ear infection; LUSC cis rs1788820 0.833 rs1429934 chr18:21162288 C/T cg14672496 chr18:21087552 C18orf8 0.43 6.78 0.35 5.5e-11 Body mass index; LUSC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg08859206 chr1:53392774 SCP2 -0.44 -7.2 -0.37 4.11e-12 Monocyte count; LUSC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06634786 chr22:41940651 POLR3H -0.49 -6.02 -0.31 4.65e-9 Vitiligo; LUSC cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg13256891 chr4:100009986 ADH5 0.46 6.39 0.33 5.71e-10 Alcohol dependence; LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg25072359 chr17:41440525 NA 0.65 9.22 0.45 3.32e-18 Menopause (age at onset); LUSC cis rs6121246 0.909 rs6119720 chr20:30347568 T/G cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.31e-11 Glomerular filtration rate (creatinine); LUSC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg19046167 chr17:80928561 B3GNTL1 0.5 7.06 0.36 9.96e-12 Glycated hemoglobin levels; LUSC cis rs4631830 0.733 rs4512771 chr10:51540906 C/A cg10326726 chr10:51549505 MSMB -0.34 -5.66 -0.3 3.34e-8 Prostate-specific antigen levels; LUSC cis rs7666738 0.546 rs11727151 chr4:98837353 A/C cg05340658 chr4:99064831 C4orf37 0.64 9.46 0.46 5.59e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs1461503 0.868 rs11602682 chr11:122842315 A/T cg27398637 chr11:122830231 C11orf63 -0.39 -6.18 -0.32 1.86e-9 Menarche (age at onset); LUSC cis rs11676348 0.873 rs10210012 chr2:219013334 G/A cg00012203 chr2:219082015 ARPC2 -0.55 -8.5 -0.42 6.33e-16 Ulcerative colitis; LUSC cis rs981844 0.922 rs2118863 chr4:154657579 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 6.96 0.36 1.85e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1267303 0.675 rs2476164 chr1:46985274 T/C cg25110126 chr1:46999211 NA -0.54 -7.36 -0.37 1.47e-12 Monobrow; LUSC cis rs7727544 0.582 rs3828675 chr5:131546868 G/A cg14196790 chr5:131705035 SLC22A5 0.45 7.43 0.38 9.24e-13 Blood metabolite levels; LUSC cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg13256891 chr4:100009986 ADH5 0.51 6.97 0.36 1.65e-11 Alcohol dependence; LUSC cis rs2607426 0.681 rs2257613 chr19:41284004 C/T cg05508168 chr19:41255947 C19orf54;SNRPA 0.88 6.79 0.35 5.16e-11 Blood protein levels; LUSC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg05776053 chr2:74358815 NA 0.45 7.13 0.36 6.06e-12 Gestational age at birth (maternal effect); LUSC cis rs1322512 0.917 rs1744382 chr6:152942064 A/G cg27316956 chr6:152958899 SYNE1 -0.34 -5.64 -0.3 3.54e-8 Tonometry; LUSC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg01616529 chr11:638424 DRD4 -0.34 -5.8 -0.3 1.58e-8 Systemic lupus erythematosus; LUSC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg14829360 chr17:73884958 NA -0.35 -5.82 -0.3 1.39e-8 White matter hyperintensity burden; LUSC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg02038168 chr22:39784481 NA -0.5 -8.35 -0.42 1.85e-15 Intelligence (multi-trait analysis); LUSC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg23649088 chr2:200775458 C2orf69 0.54 7.36 0.37 1.45e-12 Schizophrenia; LUSC cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg14844989 chr11:31128820 NA 0.4 6.14 0.32 2.34e-9 Red blood cell count; LUSC cis rs12891047 0.804 rs10141638 chr14:68318593 T/A cg20999565 chr14:68265668 ZFYVE26 0.39 5.86 0.31 1.11e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs13385 0.769 rs36050010 chr5:139569859 C/A cg26211634 chr5:139558579 C5orf32 0.44 6.29 0.33 9.75e-10 Atrial fibrillation; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg18538332 chr22:24372958 LOC391322 -0.47 -8.33 -0.41 2.09e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10188299 chr14:67982149 TMEM229B 0.49 6.59 0.34 1.77e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg12863693 chr15:85201151 NMB 0.33 6.87 0.35 3.19e-11 Schizophrenia; LUSC cis rs877282 0.945 rs71491303 chr10:772884 G/T cg17470449 chr10:769945 NA 0.51 7.07 0.36 9.06e-12 Uric acid levels; LUSC cis rs2839186 0.749 rs62226489 chr21:47710519 T/C cg11766577 chr21:47581405 C21orf56 -0.42 -6.17 -0.32 1.98e-9 Testicular germ cell tumor; LUSC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg15664640 chr17:80829946 TBCD -0.75 -13.55 -0.6 1.27e-33 Breast cancer; LUSC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg11645453 chr3:52864694 ITIH4 -0.31 -7.28 -0.37 2.44e-12 Bipolar disorder; LUSC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg20243544 chr17:37824526 PNMT 0.5 7.07 0.36 9.22e-12 Asthma; LUSC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg13877915 chr19:58951672 ZNF132 0.49 7.75 0.39 1.12e-13 Uric acid clearance; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08843538 chr2:210288784 MAP2 -0.34 -5.99 -0.31 5.53e-9 Electrocardiographic conduction measures; LUSC cis rs1712517 0.771 rs11191666 chr10:105127278 A/G cg05636881 chr10:105038444 INA 0.4 6.73 0.35 7.41e-11 Migraine; LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs17362650 0.686 rs12474540 chr2:9699313 C/T cg23886495 chr2:9695866 ADAM17 0.45 6.36 0.33 6.72e-10 Alcohol dependence (age at onset); LUSC cis rs9815354 0.680 rs75308766 chr3:42031894 G/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs11105298 0.891 rs10858902 chr12:89927789 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.4 -0.38 1.12e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg16006841 chr5:176797999 RGS14 0.64 10.36 0.49 5.33e-22 Hemoglobin concentration;Hematocrit; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg04234412 chr22:24373322 LOC391322 -0.8 -11.89 -0.55 2.06e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4268898 1.000 rs10195436 chr2:24436112 C/T cg06627628 chr2:24431161 ITSN2 0.63 9.31 0.45 1.7e-18 Asthma; LUSC trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg03929089 chr4:120376271 NA -0.45 -6.18 -0.32 1.92e-9 HDL cholesterol; LUSC cis rs9467773 1.000 rs9467782 chr6:26542773 G/A cg11502198 chr6:26597334 ABT1 0.59 9.37 0.46 1.15e-18 Intelligence (multi-trait analysis); LUSC cis rs72634258 0.503 rs2794666 chr1:7822009 A/G cg26816564 chr1:7831052 VAMP3 0.96 13.58 0.6 9.88e-34 Inflammatory bowel disease; LUSC cis rs6138458 0.962 rs6036976 chr20:24901567 T/G cg06937882 chr20:24974362 C20orf3 0.42 7.0 0.36 1.43e-11 Blood protein levels; LUSC cis rs847577 0.609 rs6465657 chr7:97816327 C/T cg21770322 chr7:97807741 LMTK2 0.56 10.08 0.48 4.99e-21 Breast cancer; LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg25072359 chr17:41440525 NA 0.66 9.45 0.46 6.08e-19 Menopause (age at onset); LUSC cis rs4409675 0.576 rs6662916 chr1:28219873 G/T cg23691781 chr1:28212827 C1orf38 0.32 7.81 0.39 7.4e-14 Corneal astigmatism; LUSC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg08219700 chr8:58056026 NA 0.48 6.28 0.32 1.07e-9 Developmental language disorder (linguistic errors); LUSC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00475322 chr7:917719 C7orf20 0.45 6.63 0.34 1.37e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs983392 0.679 rs764859 chr11:59978255 C/G cg02771260 chr11:59836817 MS4A3 -0.36 -5.79 -0.3 1.58e-8 Alzheimer's disease (late onset); LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg08859206 chr1:53392774 SCP2 0.75 14.33 0.62 1.24e-36 Monocyte count; LUSC cis rs5770917 1.000 rs2269384 chr22:51011115 C/T cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.59 -5.7 -0.3 2.66e-8 Narcolepsy; LUSC cis rs8072100 0.967 rs4794001 chr17:45720849 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -6.09 -0.32 3.13e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs929354 1.000 rs1182384 chr7:157040642 A/G cg17757837 chr7:157058334 UBE3C -0.91 -15.16 -0.64 7.01e-40 Body mass index; LUSC cis rs34779708 0.966 rs4934737 chr10:35512799 T/C cg03585969 chr10:35415529 CREM 0.64 9.53 0.46 3.46e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg26587870 chr6:27730563 NA -0.67 -6.07 -0.32 3.54e-9 Depression; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg00945038 chr17:61921165 SMARCD2 0.53 9.27 0.45 2.33e-18 Prudent dietary pattern; LUSC cis rs6964587 1.000 rs60147309 chr7:91736098 C/G cg01689657 chr7:91764605 CYP51A1 0.33 6.08 0.32 3.34e-9 Breast cancer; LUSC cis rs4144027 0.904 rs10438242 chr14:104345075 C/T cg12183467 chr14:104352244 NA -0.29 -5.93 -0.31 7.77e-9 Blood metabolite levels; LUSC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg00784671 chr22:46762841 CELSR1 -0.54 -6.57 -0.34 1.88e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg11764359 chr7:65958608 NA 0.53 6.88 0.35 2.9e-11 Aortic root size; LUSC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg05425664 chr17:57184151 TRIM37 0.54 8.01 0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22913584 chr5:81046758 SSBP2 0.48 6.75 0.35 6.59e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12618769 0.652 rs1062847 chr2:99226173 T/A cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg04865166 chr7:105162814 PUS7 0.52 5.66 0.3 3.24e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6960043 0.738 rs4721400 chr7:15059906 G/A cg19272540 chr7:15055459 NA 0.33 8.05 0.4 1.49e-14 Type 2 diabetes; LUSC cis rs11792861 0.781 rs72607158 chr9:111763010 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.56 -0.34 2e-10 Menarche (age at onset); LUSC cis rs593982 0.920 rs1151501 chr11:65484883 A/G cg08755490 chr11:65554678 OVOL1 1.53 12.92 0.58 3e-31 Atopic dermatitis; LUSC cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg04586622 chr2:25135609 ADCY3 0.42 8.93 0.44 2.89e-17 Body mass index; LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg13560548 chr3:10150139 C3orf24 -0.51 -6.78 -0.35 5.47e-11 Alzheimer's disease; LUSC cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg04727924 chr7:799746 HEATR2 -0.53 -6.48 -0.33 3.27e-10 Cerebrospinal P-tau181p levels; LUSC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg14196790 chr5:131705035 SLC22A5 -0.45 -7.53 -0.38 4.81e-13 Blood metabolite levels; LUSC cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg23711669 chr6:146136114 FBXO30 -0.86 -16.15 -0.66 9.28e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 6.12 0.32 2.67e-9 Electroencephalogram traits; LUSC cis rs34779708 0.966 rs11592567 chr10:35409369 C/T cg04310649 chr10:35416472 CREM -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs3806843 1.000 rs11167600 chr5:140174865 G/C cg25815440 chr2:42134162 NA -0.26 -5.97 -0.31 5.96e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs73200209 0.744 rs59619030 chr12:116475001 T/C cg01776926 chr12:116560359 MED13L -0.5 -5.97 -0.31 6.1e-9 Total body bone mineral density; LUSC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.76 0.39 1.04e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg01475377 chr6:109611718 NA -0.41 -7.38 -0.37 1.24e-12 Reticulocyte fraction of red cells; LUSC cis rs7246967 0.611 rs57013651 chr19:22863027 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs9506514 0.712 rs11838795 chr13:21258328 T/C cg04906043 chr13:21280425 IL17D -0.3 -5.66 -0.3 3.31e-8 Coronary artery calcification; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03328750 chr5:142150401 ARHGAP26 0.44 6.34 0.33 7.25e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg15557168 chr22:42548783 NA 0.37 6.34 0.33 7.48e-10 Cognitive function; LUSC trans rs62103177 0.608 rs551643 chr18:77838970 C/G cg05926928 chr17:57297772 GDPD1 -0.89 -10.31 -0.49 8.13e-22 Opioid sensitivity; LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg22535103 chr8:58192502 C8orf71 -0.77 -7.98 -0.4 2.39e-14 Developmental language disorder (linguistic errors); LUSC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg03115019 chr17:80708279 FN3K 0.48 5.75 0.3 2e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); LUSC cis rs11190604 1.000 rs4604805 chr10:102261409 C/G cg16342193 chr10:102329863 NA -0.34 -6.17 -0.32 1.98e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9807989 0.839 rs4851565 chr2:102971481 C/A cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs7769051 0.522 rs6927991 chr6:133113888 T/G cg22852734 chr6:133119734 C6orf192 1.34 10.57 0.5 1.05e-22 Type 2 diabetes nephropathy; LUSC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg13319975 chr6:146136371 FBXO30 -0.71 -11.06 -0.52 1.96e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg02782426 chr3:40428986 ENTPD3 0.41 7.71 0.39 1.41e-13 Renal cell carcinoma; LUSC cis rs116095464 0.558 rs10068203 chr5:206618 C/T cg22496380 chr5:211416 CCDC127 -0.85 -8.77 -0.43 9.3e-17 Breast cancer; LUSC cis rs16866061 1.000 rs72974269 chr2:225454907 C/T cg12698349 chr2:225449008 CUL3 0.85 14.02 0.61 1.99e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs9831754 1.000 rs3946823 chr3:78353052 G/A cg06138941 chr3:78371609 NA -0.76 -10.07 -0.48 5.17e-21 Calcium levels; LUSC cis rs7220401 0.789 rs3760456 chr17:27948844 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -9.58 -0.46 2.27e-19 Coronary artery disease; LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18404041 chr3:52824283 ITIH1 -0.62 -12.01 -0.55 7.56e-28 Bipolar disorder; LUSC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg24531977 chr5:56204891 C5orf35 -0.55 -8.08 -0.4 1.19e-14 Breast cancer;Breast cancer (early onset); LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg09436375 chr6:42928200 GNMT -0.29 -6.82 -0.35 4.33e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg10802521 chr3:52805072 NEK4 -0.56 -9.11 -0.45 7.82e-18 Bipolar disorder; LUSC cis rs367615 0.512 rs246105 chr5:108672946 C/T cg17395555 chr5:108820864 NA 0.54 9.6 0.46 2.02e-19 Colorectal cancer (SNP x SNP interaction); LUSC trans rs2048656 0.570 rs7814635 chr8:9646620 G/A cg15556689 chr8:8085844 FLJ10661 0.46 6.59 0.34 1.7e-10 Schizophrenia; LUSC trans rs9329221 0.905 rs4433149 chr8:10249268 A/T cg15556689 chr8:8085844 FLJ10661 -0.61 -9.54 -0.46 3.21e-19 Neuroticism; LUSC cis rs17095355 1.000 rs3862006 chr10:111750764 A/G cg00817464 chr10:111662876 XPNPEP1 0.6 7.76 0.39 1.08e-13 Biliary atresia; LUSC cis rs1577917 1.000 rs12200330 chr6:86656653 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.88 -0.44 4.11e-17 Response to antipsychotic treatment; LUSC cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg04545296 chr12:48745243 ZNF641 0.37 6.72 0.35 7.87e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg02187348 chr16:89574699 SPG7 0.48 7.4 0.38 1.12e-12 Multiple myeloma (IgH translocation); LUSC trans rs9860340 0.770 rs7631474 chr3:87643214 C/T cg03644585 chr7:884825 UNC84A 0.42 6.01 0.31 4.84e-9 Electroencephalographic traits in alcoholism; LUSC trans rs7824557 0.767 rs2164273 chr8:11168499 A/G cg15556689 chr8:8085844 FLJ10661 0.57 8.7 0.43 1.53e-16 Retinal vascular caliber; LUSC cis rs2067615 0.579 rs66716938 chr12:107196825 T/C cg15890332 chr12:107067104 RFX4 0.34 6.18 0.32 1.91e-9 Heart rate; LUSC cis rs9677476 1.000 rs6711312 chr2:232122348 T/C cg07929768 chr2:232055508 NA 0.3 5.7 0.3 2.69e-8 Food antigen IgG levels; LUSC cis rs7615316 0.934 rs13093869 chr3:142319213 G/C cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.58e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.87 0.31 1.06e-8 Life satisfaction; LUSC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg07701084 chr6:150067640 NUP43 0.57 8.7 0.43 1.49e-16 Lung cancer; LUSC cis rs35306767 0.714 rs11250228 chr10:1074887 A/G cg20503657 chr10:835505 NA 0.58 7.62 0.38 2.7e-13 Eosinophil percentage of granulocytes; LUSC cis rs7804356 1.000 rs3823932 chr7:26853980 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC trans rs3857536 0.813 rs4710581 chr6:66939954 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC trans rs61931739 0.500 rs28692887 chr12:34457075 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.81 0.51 1.49e-23 Morning vs. evening chronotype; LUSC cis rs7312933 0.566 rs11181454 chr12:42746486 T/C cg01256987 chr12:42539512 GXYLT1 0.34 6.11 0.32 2.73e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg08439880 chr3:133502540 NA -0.33 -6.0 -0.31 5.26e-9 Iron status biomarkers; LUSC cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg25173405 chr17:45401733 C17orf57 -0.37 -5.78 -0.3 1.75e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8017423 0.935 rs10147186 chr14:90779879 G/C cg04374321 chr14:90722782 PSMC1 0.68 10.52 0.5 1.52e-22 Mortality in heart failure; LUSC trans rs2832191 0.716 rs1888439 chr21:30454457 A/G cg14791747 chr16:20752902 THUMPD1 -0.4 -6.07 -0.32 3.44e-9 Dental caries; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg12564285 chr5:131593104 PDLIM4 0.56 10.64 0.5 6.04e-23 Acylcarnitine levels; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg05165339 chr4:1420672 NA -0.28 -6.3 -0.33 9.57e-10 Longevity; LUSC cis rs72634258 0.945 rs2050198 chr1:8111839 T/G cg26816564 chr1:7831052 VAMP3 0.5 6.15 0.32 2.18e-9 Inflammatory bowel disease; LUSC cis rs7089973 0.624 rs11196930 chr10:116583596 C/T cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.17e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12989701 1.000 rs13004848 chr2:127887560 C/T cg08168897 chr2:127865431 BIN1 -0.69 -8.52 -0.42 5.71e-16 Alzheimer's disease (late onset); LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg13397359 chr6:42928475 GNMT 0.57 9.5 0.46 4.34e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7927771 0.524 rs4752860 chr11:47705015 C/A cg20307385 chr11:47447363 PSMC3 -0.43 -6.3 -0.33 9.19e-10 Subjective well-being; LUSC cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg15605315 chr1:45957053 TESK2 -0.42 -6.65 -0.34 1.19e-10 High light scatter reticulocyte count; LUSC cis rs9325144 0.671 rs7306605 chr12:38730471 C/T cg13010199 chr12:38710504 ALG10B 0.47 7.3 0.37 2.17e-12 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg00166722 chr3:10149974 C3orf24 0.62 8.7 0.43 1.52e-16 Alzheimer's disease; LUSC cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg02527881 chr3:46936655 PTH1R -0.39 -6.76 -0.35 6.22e-11 Colorectal cancer; LUSC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg21963583 chr11:68658836 MRPL21 0.55 8.66 0.43 2.04e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg15704280 chr7:45808275 SEPT13 -0.84 -14.12 -0.61 8.07e-36 Height; LUSC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.75 0.43 1.09e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2273669 0.667 rs116189763 chr6:109302894 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg27121462 chr16:89883253 FANCA 0.53 8.29 0.41 2.76e-15 Vitiligo; LUSC cis rs7267979 0.966 rs2261790 chr20:25262789 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.49 0.75 5.16e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9790314 1.000 rs336593 chr3:161076431 T/C cg03342759 chr3:160939853 NMD3 -0.48 -8.18 -0.41 5.8e-15 Morning vs. evening chronotype; LUSC cis rs9326248 0.559 rs1269329 chr11:116755041 T/C cg26566898 chr11:117069891 TAGLN 0.37 7.02 0.36 1.28e-11 Blood protein levels; LUSC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.77 7.46 0.38 7.35e-13 Cerebrospinal P-tau181p levels; LUSC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg06481639 chr22:41940642 POLR3H 0.48 5.76 0.3 1.93e-8 Vitiligo; LUSC cis rs1322512 0.874 rs2254037 chr6:153016317 G/C cg27316956 chr6:152958899 SYNE1 0.36 6.19 0.32 1.81e-9 Tonometry; LUSC cis rs1559088 0.947 rs12461297 chr19:33559245 A/G cg17764715 chr19:33622953 WDR88 0.59 7.95 0.4 2.96e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs8014204 0.967 rs4903266 chr14:75344941 C/G cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.34 -0.53 1.88e-25 Caffeine consumption; LUSC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.11e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs72634258 0.842 rs4325151 chr1:8168917 T/A cg00042356 chr1:8021962 PARK7 -0.58 -7.05 -0.36 1.06e-11 Inflammatory bowel disease; LUSC cis rs6938 0.534 rs11854704 chr15:75221015 C/T cg14664628 chr15:75095509 CSK -0.53 -7.99 -0.4 2.17e-14 Breast cancer; LUSC cis rs9467773 0.609 rs12663780 chr6:26397573 T/C cg09904177 chr6:26538194 HMGN4 -0.54 -8.04 -0.4 1.59e-14 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg04369109 chr6:150039330 LATS1 -0.56 -8.28 -0.41 3.03e-15 Lung cancer; LUSC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg26314531 chr2:26401878 FAM59B -0.68 -9.32 -0.45 1.67e-18 Gut microbiome composition (summer); LUSC cis rs6540559 0.543 rs664097 chr1:210422179 C/T cg22029157 chr1:209979665 IRF6 0.57 6.48 0.33 3.21e-10 Cleft lip with or without cleft palate; LUSC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg04287289 chr16:89883240 FANCA -0.42 -6.05 -0.31 3.99e-9 Vitiligo; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04225523 chr3:133292095 CDV3 0.41 6.04 0.31 4.07e-9 Triglycerides; LUSC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg27286337 chr10:134555280 INPP5A 0.92 12.05 0.55 5.3e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs80130819 0.688 rs7305418 chr12:48586112 A/G cg24011408 chr12:48396354 COL2A1 0.44 5.67 0.3 3.1e-8 Prostate cancer; LUSC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg09021430 chr5:549028 NA -0.57 -7.67 -0.39 1.92e-13 Obesity-related traits; LUSC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg11764359 chr7:65958608 NA 0.81 13.5 0.59 1.91e-33 Aortic root size; LUSC cis rs2361710 1.000 rs2361710 chr17:78111877 C/T cg09238746 chr17:78121135 EIF4A3 0.53 8.17 0.41 6.55e-15 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs10170310 1.000 rs6720716 chr2:139268802 A/G cg10095539 chr2:139258744 SPOPL 0.33 5.89 0.31 9.45e-9 Response to antipsychotic treatment; LUSC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20419410 chr7:155089803 INSIG1 -0.43 -6.36 -0.33 6.78e-10 Electrocardiographic conduction measures; LUSC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg15556689 chr8:8085844 FLJ10661 -0.65 -10.28 -0.49 1.05e-21 Mood instability; LUSC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg05340658 chr4:99064831 C4orf37 0.63 10.02 0.48 7.77e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg07389463 chr12:132296394 NA -0.46 -8.87 -0.44 4.59e-17 Migraine; LUSC cis rs3087591 0.960 rs1801052 chr17:29508775 C/T cg24425628 chr17:29625626 OMG;NF1 0.56 8.13 0.41 8.72e-15 Hip circumference; LUSC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg24879335 chr3:133465180 TF 0.45 7.82 0.39 7.1e-14 Iron status biomarkers (transferrin levels); LUSC cis rs3126085 0.825 rs4845428 chr1:152225261 T/C cg26876637 chr1:152193138 HRNR 0.44 6.19 0.32 1.73e-9 Atopic dermatitis; LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs1160297 0.601 rs1864534 chr2:53109005 G/T cg07782112 chr2:53107842 NA 0.39 6.48 0.33 3.27e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg24397884 chr7:158709396 WDR60 0.62 9.38 0.46 1.02e-18 Height; LUSC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg06028605 chr16:24865363 SLC5A11 -0.51 -9.01 -0.44 1.6e-17 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G ch.2.1636738F chr2:72222117 NA -0.41 -6.31 -0.33 9.02e-10 Electrocardiographic conduction measures; LUSC cis rs513349 1.000 rs210145 chr6:33547440 G/C cg07679836 chr6:33548423 BAK1 0.33 5.86 0.31 1.12e-8 Platelet count; LUSC trans rs3857536 0.706 rs1418854 chr6:66893284 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.4 -0.33 5.35e-10 Blood trace element (Cu levels); LUSC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg13175981 chr1:150552382 MCL1 0.55 7.8 0.39 8.03e-14 Tonsillectomy; LUSC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg06808227 chr14:105710500 BRF1 -0.67 -10.39 -0.49 4.17e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs754466 0.606 rs56402185 chr10:79585848 G/A cg17075019 chr10:79541650 NA -0.77 -12.55 -0.57 7.5e-30 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg16405210 chr4:1374714 KIAA1530 -0.63 -10.37 -0.49 4.93e-22 Longevity; LUSC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg03351412 chr1:154909251 PMVK 0.53 8.39 0.42 1.42e-15 Prostate cancer; LUSC cis rs6961069 0.527 rs3211827 chr7:80279460 A/C cg04458919 chr7:80252533 CD36 -0.39 -6.72 -0.35 7.79e-11 Platelet count; LUSC cis rs7000551 0.642 rs2449328 chr8:22375043 A/G cg12081754 chr8:22256438 SLC39A14 0.44 6.55 0.34 2.21e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs892961 0.836 rs35077273 chr17:75412415 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg20936695 chr7:66093774 KCTD7 -0.62 -5.97 -0.31 5.97e-9 Diabetic kidney disease; LUSC cis rs7072216 0.922 rs4539242 chr10:100148058 T/C cg26618903 chr10:100175079 PYROXD2 -0.29 -5.75 -0.3 2e-8 Metabolite levels; LUSC cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg07061783 chr6:25882402 NA -0.38 -5.86 -0.31 1.08e-8 Blood metabolite levels; LUSC cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg03146154 chr1:46216737 IPP 0.52 7.67 0.39 1.9e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24786498 chr4:53578478 SNORA26;KIAA0114 -0.4 -5.97 -0.31 6.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01035107 chr19:48281693 SEPW1 -0.45 -6.71 -0.34 8.25e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6545883 0.929 rs9679557 chr2:61709349 C/A cg15711740 chr2:61764176 XPO1 -0.44 -6.69 -0.34 9.64e-11 Tuberculosis; LUSC cis rs6681460 0.649 rs10889625 chr1:67007235 T/C cg02459107 chr1:67143332 SGIP1 0.38 6.42 0.33 4.68e-10 Presence of antiphospholipid antibodies; LUSC cis rs9287719 0.934 rs4371336 chr2:10755723 C/A cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02725935 chr1:120612404 NOTCH2 -0.43 -6.31 -0.33 8.81e-10 Electrocardiographic conduction measures; LUSC trans rs5770872 0.521 rs7511047 chr22:50816619 A/G cg09860653 chr1:19970708 NBL1 -0.48 -7.15 -0.36 5.59e-12 Tonsillectomy; LUSC cis rs11158026 0.603 rs11846514 chr14:55440340 A/C cg04306507 chr14:55594613 LGALS3 0.4 7.47 0.38 7e-13 Parkinson's disease; LUSC cis rs72720396 1.000 rs72720396 chr1:91191582 A/G cg13456504 chr1:91191583 NA 0.63 8.56 0.42 4.09e-16 Morning vs. evening chronotype;Chronotype; LUSC cis rs1577917 0.916 rs4706252 chr6:86555180 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg04944784 chr2:26401820 FAM59B 0.78 11.21 0.52 5.48e-25 Gut microbiome composition (summer); LUSC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.78 -0.72 3.21e-54 Height; LUSC cis rs9300255 0.602 rs1402274 chr12:123686224 T/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.89 -0.31 9.5e-9 Neutrophil percentage of white cells; LUSC cis rs2652834 0.950 rs2729787 chr15:63401493 G/T cg05507819 chr15:63340323 TPM1 0.66 7.95 0.4 2.84e-14 HDL cholesterol; LUSC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg01448562 chr3:133502909 NA 0.77 13.9 0.61 5.55e-35 Iron status biomarkers; LUSC cis rs1823874 0.581 rs11855419 chr15:100327480 A/G cg16400843 chr15:100339927 C15orf51 -0.37 -6.75 -0.35 6.45e-11 IgG glycosylation; LUSC cis rs2731664 0.792 rs2545795 chr5:176887106 A/C cg23176889 chr5:176863531 GRK6 -0.64 -12.99 -0.58 1.7e-31 Intelligence (multi-trait analysis); LUSC trans rs1376359 0.537 rs471949 chr1:103255403 A/G cg17154563 chr19:40477487 PSMC4 0.48 6.04 0.31 4.22e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC trans rs6982636 1.000 rs2980853 chr8:126478350 G/T cg13325919 chr3:181432053 SOX2;SOX2OT 0.33 6.35 0.33 7.09e-10 Lipid metabolism phenotypes; LUSC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs77741769 0.529 rs12579868 chr12:121207147 C/T cg02419362 chr12:121203948 SPPL3 0.46 8.55 0.42 4.63e-16 Mean corpuscular volume; LUSC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg12463550 chr7:65579703 CRCP 0.45 6.58 0.34 1.84e-10 Aortic root size; LUSC cis rs12682352 0.602 rs28399241 chr8:8663215 C/T cg14343924 chr8:8086146 FLJ10661 0.45 5.94 0.31 7.24e-9 Neuroticism; LUSC trans rs7937682 1.000 rs7128353 chr11:111538875 A/G cg18187862 chr3:45730750 SACM1L 0.54 7.0 0.36 1.39e-11 Primary sclerosing cholangitis; LUSC cis rs9309473 0.607 rs1851546 chr2:73591127 C/A cg20560298 chr2:73613845 ALMS1 -0.59 -8.88 -0.44 4.12e-17 Metabolite levels; LUSC cis rs8058578 0.633 rs113448632 chr16:30898219 C/T cg02466173 chr16:30829666 NA -0.53 -8.68 -0.43 1.83e-16 Multiple myeloma; LUSC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.23 -0.32 1.42e-9 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs644799 0.735 rs10831432 chr11:95516040 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.87 13.76 0.6 1.96e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6750047 0.546 rs1367696 chr2:38286914 C/T cg07380506 chr2:38303506 CYP1B1 0.5 6.89 0.35 2.83e-11 Cutaneous malignant melanoma;Melanoma; LUSC cis rs4654899 0.758 rs35913932 chr1:21423025 G/T cg01072550 chr1:21505969 NA -0.51 -7.78 -0.39 9.1e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg25456477 chr12:86230367 RASSF9 0.43 7.69 0.39 1.65e-13 Major depressive disorder; LUSC trans rs4811340 0.600 rs6068250 chr20:51179959 A/G cg15736553 chr3:11610338 VGLL4 -0.33 -5.95 -0.31 6.7e-9 Thyroid peroxidase antibody positivity; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg22868518 chr11:507468 RNH1 -0.63 -5.87 -0.31 1.08e-8 Body mass index; LUSC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg02269571 chr22:50332266 NA -0.55 -8.12 -0.41 9.15e-15 Schizophrenia; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.32 0.41 2.31e-15 Prudent dietary pattern; LUSC cis rs713477 0.935 rs12888181 chr14:55906082 A/C cg13175173 chr14:55914753 NA -0.32 -6.77 -0.35 5.7e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs9325144 0.560 rs10785586 chr12:38676197 G/A cg26384229 chr12:38710491 ALG10B -0.66 -10.17 -0.49 2.45e-21 Morning vs. evening chronotype; LUSC cis rs7100689 0.622 rs1890890 chr10:82090643 A/T cg00277334 chr10:82204260 NA -0.58 -8.84 -0.44 5.72e-17 Post bronchodilator FEV1; LUSC cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg08999081 chr20:33150536 PIGU 0.38 6.76 0.35 6.24e-11 Height; LUSC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg13175981 chr1:150552382 MCL1 0.47 6.62 0.34 1.43e-10 Tonsillectomy; LUSC cis rs3820068 0.608 rs12092485 chr1:16048038 A/G cg17385448 chr1:15911702 AGMAT 0.36 5.92 0.31 8.13e-9 Systolic blood pressure; LUSC trans rs6502050 0.814 rs9894554 chr17:80073423 C/G cg07393940 chr7:158741817 NA -0.37 -6.66 -0.34 1.15e-10 Life satisfaction; LUSC cis rs7119 0.717 rs7176307 chr15:77816684 G/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs7809950 0.953 rs28687365 chr7:107106712 A/C cg23024343 chr7:107201750 COG5 -0.54 -8.69 -0.43 1.69e-16 Coronary artery disease; LUSC cis rs4969178 0.965 rs12451791 chr17:76397343 G/A cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs16854884 0.558 rs60367530 chr3:143719294 G/A cg01302019 chr3:143689584 C3orf58 -0.35 -5.81 -0.3 1.44e-8 Economic and political preferences (feminism/equality); LUSC cis rs12545109 0.800 rs2610058 chr8:57409120 G/A cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.1e-10 Obesity-related traits; LUSC cis rs6977660 1.000 rs6974669 chr7:19793296 T/A cg05791153 chr7:19748676 TWISTNB 0.66 7.42 0.38 9.92e-13 Thyroid stimulating hormone; LUSC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.65 0.39 2.17e-13 Parkinson's disease; LUSC cis rs909341 0.859 rs3208008 chr20:62326110 A/C cg09650180 chr20:62225654 GMEB2 0.46 5.99 0.31 5.51e-9 Atopic dermatitis; LUSC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg11752832 chr7:134001865 SLC35B4 0.55 8.7 0.43 1.52e-16 Mean platelet volume; LUSC cis rs12908161 1.000 rs12899981 chr15:85302373 G/A cg17173187 chr15:85201210 NMB 0.5 9.39 0.46 9.83e-19 Schizophrenia; LUSC trans rs2392780 0.896 rs17465317 chr8:128356670 C/T cg10897648 chr18:56338258 MALT1 -0.4 -6.13 -0.32 2.44e-9 Breast cancer (early onset); LUSC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg15110403 chr19:17392923 ANKLE1 -0.6 -8.33 -0.41 2.11e-15 Systemic lupus erythematosus; LUSC cis rs3820928 1.000 rs10197757 chr2:227763244 A/C cg11843606 chr2:227700838 RHBDD1 -0.52 -7.61 -0.38 2.79e-13 Pulmonary function; LUSC cis rs7621025 0.664 rs6439657 chr3:136494639 C/T cg15507776 chr3:136538369 TMEM22 -0.41 -5.73 -0.3 2.2e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs738322 0.839 rs9607517 chr22:38596100 G/A cg25457927 chr22:38595422 NA 0.49 10.51 0.5 1.69e-22 Cutaneous nevi; LUSC cis rs11098499 0.663 rs9996501 chr4:120238918 C/A cg09307838 chr4:120376055 NA 0.71 10.61 0.5 7.43e-23 Corneal astigmatism; LUSC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg13535736 chr9:111863775 C9orf5 -0.43 -6.88 -0.35 2.94e-11 Menarche (age at onset); LUSC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg02423579 chr7:2872169 GNA12 -0.37 -5.73 -0.3 2.21e-8 Height; LUSC cis rs7296418 0.663 rs11057284 chr12:123830692 G/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.15 -0.41 7.45e-15 Platelet count; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.17 0.32 1.95e-9 Menopause (age at onset); LUSC cis rs9309473 0.950 rs6546849 chr2:73831037 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.63 -0.34 1.37e-10 Metabolite levels; LUSC cis rs9837602 1.000 rs2291494 chr3:99781805 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.37 5.68 0.3 2.98e-8 Breast cancer; LUSC cis rs59104589 0.617 rs60614486 chr2:242274998 C/G cg14842376 chr2:242211374 HDLBP 0.59 6.56 0.34 2.01e-10 Fibrinogen levels; LUSC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.26 -0.41 3.38e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7524258 0.868 rs4243824 chr1:7289777 G/A cg07173049 chr1:7289937 CAMTA1 0.36 7.5 0.38 5.89e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.94 0.4 3.06e-14 Bipolar disorder; LUSC cis rs2204008 0.729 rs114133083 chr12:38182923 G/C cg26384229 chr12:38710491 ALG10B -0.67 -10.46 -0.5 2.35e-22 Bladder cancer; LUSC cis rs7580658 0.963 rs6732279 chr2:128089540 G/T cg09760422 chr2:128146352 NA -0.33 -7.14 -0.36 6e-12 Protein C levels; LUSC cis rs4595586 0.545 rs1562728 chr12:39405740 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.16e-12 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg05313129 chr8:58192883 C8orf71 -0.5 -6.51 -0.34 2.8e-10 Developmental language disorder (linguistic errors); LUSC cis rs9457247 0.871 rs1811121 chr6:167403539 T/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg22823121 chr1:150693482 HORMAD1 0.51 7.89 0.4 4.49e-14 Tonsillectomy; LUSC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg23649088 chr2:200775458 C2orf69 0.78 14.38 0.62 7.93e-37 Osteoporosis; LUSC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.71 0.34 8.51e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs1577917 0.917 rs35038582 chr6:86721305 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.22 -0.41 4.54e-15 Response to antipsychotic treatment; LUSC trans rs12310956 0.532 rs11052935 chr12:33970946 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.82 0.51 1.33e-23 Morning vs. evening chronotype; LUSC cis rs7248779 0.532 rs10153475 chr19:2413961 G/C cg22729335 chr19:2427816 TIMM13 1.07 19.06 0.72 2.49e-55 Cortisol levels (saliva); LUSC cis rs7945705 0.738 rs11042067 chr11:8815453 T/C cg12365402 chr11:9010492 NRIP3 -0.45 -8.34 -0.42 2.01e-15 Hemoglobin concentration; LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.95 0.31 6.61e-9 Menopause (age at onset); LUSC cis rs4363385 0.818 rs4845514 chr1:153000820 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.92 -0.4 3.59e-14 Inflammatory skin disease; LUSC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 6.04 0.31 4.03e-9 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg13798780 chr7:105162888 PUS7 0.57 6.08 0.32 3.37e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg05340658 chr4:99064831 C4orf37 0.68 11.73 0.54 7.63e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.24e-11 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg05347473 chr6:146136440 FBXO30 0.56 9.49 0.46 4.63e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.811 rs7011229 chr8:8543324 T/C cg18904891 chr8:8559673 CLDN23 -0.38 -5.88 -0.31 9.98e-9 Mood instability; LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.71 0.6 2.94e-34 Platelet count; LUSC trans rs2739330 0.828 rs5760102 chr22:24248761 T/C cg06437703 chr8:37914619 EIF4EBP1 -0.57 -8.72 -0.43 1.31e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7511006 1.000 rs7290710 chr22:50677454 C/T cg16473166 chr22:50639996 SELO 0.58 7.73 0.39 1.27e-13 Obesity-related traits; LUSC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg23205692 chr1:25664452 TMEM50A 0.41 6.19 0.32 1.8e-9 Erythrocyte sedimentation rate; LUSC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg01570182 chr17:44337453 NA -0.69 -10.43 -0.5 3.03e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3540 0.574 rs2657946 chr15:90967513 G/C cg03599575 chr15:90893182 GABARAPL3 0.33 5.93 0.31 7.59e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg13531842 chr10:38383804 ZNF37A -0.44 -6.72 -0.35 7.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg04181038 chr4:183730758 NA 0.81 13.42 0.59 3.94e-33 Pediatric autoimmune diseases; LUSC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg08219700 chr8:58056026 NA 0.47 6.2 0.32 1.67e-9 Developmental language disorder (linguistic errors); LUSC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg20573242 chr4:122745356 CCNA2 0.64 9.22 0.45 3.55e-18 Type 2 diabetes; LUSC cis rs9287719 0.967 rs10454738 chr2:10742049 G/A cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs73198271 0.960 rs11776546 chr8:8609181 T/G cg01851573 chr8:8652454 MFHAS1 0.6 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10782582 0.586 rs1856791 chr1:76308942 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.39 -0.33 5.51e-10 Daytime sleep phenotypes; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg06877462 chr1:205807181 PM20D1 -0.39 -6.97 -0.36 1.66e-11 Menarche (age at onset); LUSC cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg06462663 chr19:18546047 ISYNA1 0.47 8.01 0.4 1.95e-14 Breast cancer; LUSC cis rs2980439 0.557 rs2976876 chr8:8318850 T/C cg06636001 chr8:8085503 FLJ10661 0.67 10.88 0.51 8.52e-24 Neuroticism; LUSC cis rs7647973 0.696 rs3087866 chr3:49054692 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.66 9.78 0.47 4.94e-20 Menarche (age at onset); LUSC cis rs17270561 0.666 rs1937129 chr6:25789132 A/G cg16482183 chr6:26056742 HIST1H1C 0.56 8.13 0.41 8.45e-15 Iron status biomarkers; LUSC cis rs3820068 0.705 rs4646085 chr1:15825411 A/T cg17385448 chr1:15911702 AGMAT 0.37 5.78 0.3 1.76e-8 Systolic blood pressure; LUSC cis rs983392 0.680 rs11230201 chr11:59996994 C/G cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.32 0.41 2.27e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs7726839 0.540 rs72703095 chr5:601789 T/C cg25482853 chr8:67687455 SGK3 1.12 15.79 0.65 2.41e-42 Obesity-related traits; LUSC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.09e-11 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg00409905 chr10:38381863 ZNF37A -0.4 -6.79 -0.35 5e-11 Extrinsic epigenetic age acceleration; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07754938 chr3:48885314 PRKAR2A -0.45 -6.84 -0.35 3.81e-11 Electrocardiographic conduction measures; LUSC cis rs11958404 0.932 rs72816581 chr5:157432591 T/A cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg23625390 chr15:77176239 SCAPER 0.52 8.1 0.41 1.02e-14 Blood metabolite levels; LUSC cis rs1670533 1.000 rs2045069 chr4:1052206 T/C cg27284194 chr4:1044797 NA 0.58 8.61 0.43 2.92e-16 Recombination rate (females); LUSC cis rs981844 0.775 rs72733610 chr4:154732336 A/G cg14289246 chr4:154710475 SFRP2 0.47 6.29 0.33 9.72e-10 Response to statins (LDL cholesterol change); LUSC cis rs10871290 0.881 rs3863436 chr16:74468038 T/C cg01733217 chr16:74700730 RFWD3 -0.62 -8.99 -0.44 1.92e-17 Breast cancer; LUSC cis rs7072216 0.727 rs942809 chr10:100168001 G/A cg26618903 chr10:100175079 PYROXD2 -0.46 -8.71 -0.43 1.39e-16 Metabolite levels; LUSC cis rs262150 1.000 rs262149 chr7:158778256 A/G cg09640425 chr7:158790006 NA 0.42 6.44 0.33 4.09e-10 Facial morphology (factor 20); LUSC cis rs920590 0.684 rs7461774 chr8:19666645 G/A cg03894339 chr8:19674705 INTS10 0.58 7.7 0.39 1.59e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.16 -0.41 6.74e-15 Type 2 diabetes; LUSC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg17366294 chr4:99064904 C4orf37 0.54 8.66 0.43 2.08e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs11229555 0.645 rs4579945 chr11:58190873 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg03264133 chr6:25882463 NA -0.44 -7.61 -0.38 2.87e-13 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg16386425 chr10:429943 DIP2C -0.43 -6.87 -0.35 3.18e-11 Psychosis in Alzheimer's disease; LUSC cis rs1595825 0.891 rs16824264 chr2:198675917 T/C cg00982548 chr2:198649783 BOLL -0.6 -7.44 -0.38 8.52e-13 Ulcerative colitis; LUSC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg01475377 chr6:109611718 NA -0.38 -6.67 -0.34 1.04e-10 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; LUSC cis rs11240408 1 rs11240408 chr1:205264536 A/T cg21643547 chr1:205240462 TMCC2 0.5 9.55 0.46 2.98e-19 Platelet count; LUSC cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg15073853 chr19:18549131 ISYNA1 -0.31 -5.69 -0.3 2.78e-8 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24262715 chr15:44038991 PDIA3;CATSPER2P1 0.38 6.13 0.32 2.47e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs116988415 0.584 rs75851540 chr14:65262909 C/T cg25083366 chr14:65239357 SPTB 0.67 6.9 0.35 2.64e-11 Daytime sleep phenotypes; LUSC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC cis rs2629540 0.889 rs4962699 chr10:126477209 A/G cg08799069 chr10:126477246 METTL10 -0.72 -11.3 -0.53 2.63e-25 Cocaine dependence; LUSC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg21770322 chr7:97807741 LMTK2 0.46 7.85 0.39 5.81e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9462027 0.628 rs1998702 chr6:34741917 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.31 -5.66 -0.3 3.33e-8 Systemic lupus erythematosus; LUSC cis rs7586879 0.828 rs13428789 chr2:25087643 C/T cg04586622 chr2:25135609 ADCY3 0.3 5.74 0.3 2.09e-8 Body mass index; LUSC cis rs9303401 0.614 rs34843288 chr17:57103140 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 12.48 0.56 1.38e-29 Cognitive test performance; LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs2656056 1 rs2656056 chr15:78722519 T/C cg24631222 chr15:78858424 CHRNA5 -0.67 -9.03 -0.44 1.39e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs317689 0.690 rs317656 chr12:69681101 T/A cg20891283 chr12:69753455 YEATS4 0.43 5.69 0.3 2.74e-8 Response to diuretic therapy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23922560 chr14:37117375 NA 0.44 6.47 0.33 3.47e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11890956 chr21:40555474 PSMG1 1.03 20.49 0.75 5.09e-61 Cognitive function; LUSC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg20476274 chr7:133979776 SLC35B4 0.83 15.25 0.64 3.17e-40 Mean platelet volume; LUSC cis rs7799006 0.606 rs878534 chr7:2314652 G/A cg12823233 chr7:2316876 SNX8 -0.45 -7.63 -0.39 2.41e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg18196295 chr10:418757 DIP2C -0.51 -8.36 -0.42 1.71e-15 Psychosis in Alzheimer's disease; LUSC cis rs11122272 0.735 rs2244986 chr1:231537452 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -10.03 -0.48 7.13e-21 Hemoglobin concentration; LUSC trans rs1005277 0.579 rs1740742 chr10:38518860 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.51 -0.46 3.89e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7267979 0.740 rs2259961 chr20:25282626 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.77 16.24 0.66 4.1e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10779751 0.734 rs1211575 chr1:11118390 G/A cg08854313 chr1:11322531 MTOR 0.77 11.33 0.53 2.18e-25 Body mass index; LUSC trans rs62103177 0.673 rs36087369 chr18:77589596 C/G cg05926928 chr17:57297772 GDPD1 1.03 12.92 0.58 3.01e-31 Opioid sensitivity; LUSC cis rs1577917 0.958 rs28442244 chr6:86701236 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.09 0.4 1.09e-14 Response to antipsychotic treatment; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg25703541 chr22:24373054 LOC391322 -1.0 -18.23 -0.71 4.8e-52 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3126085 0.935 rs4326625 chr1:152223996 C/T cg03465714 chr1:152285911 FLG -0.4 -5.83 -0.3 1.34e-8 Atopic dermatitis; LUSC cis rs10896135 0.526 rs1987169 chr11:66448044 A/G cg24851651 chr11:66362959 CCS -0.53 -8.54 -0.42 4.91e-16 Bipolar disorder; LUSC cis rs1865760 1.000 rs9467636 chr6:25919549 A/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.82 0.35 4.38e-11 Height; LUSC cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg13319975 chr6:146136371 FBXO30 0.5 7.52 0.38 5.18e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1595825 0.891 rs59990242 chr2:198895868 G/A cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17121955 chr11:6411382 SMPD1 -0.51 -6.82 -0.35 4.16e-11 Bipolar disorder and schizophrenia; LUSC cis rs9467773 0.935 rs1884947 chr6:26553273 G/T cg11502198 chr6:26597334 ABT1 0.59 8.82 0.43 6.52e-17 Intelligence (multi-trait analysis); LUSC cis rs7223966 1.000 rs56383601 chr17:61929968 A/C cg05941027 chr17:61774174 LIMD2 0.22 5.7 0.3 2.66e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg23985595 chr17:80112537 CCDC57 -0.31 -6.01 -0.31 4.74e-9 Life satisfaction; LUSC cis rs8078723 0.630 rs60137005 chr17:38129996 A/T cg17467752 chr17:38218738 THRA 0.53 7.9 0.4 3.97e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs73001065 0.818 rs16996185 chr19:19720788 G/T cg03709012 chr19:19516395 GATAD2A -0.88 -7.15 -0.36 5.53e-12 LDL cholesterol; LUSC cis rs765787 0.530 rs28414644 chr15:45536721 G/C cg25801113 chr15:45476975 SHF 0.36 7.27 0.37 2.55e-12 Uric acid levels; LUSC cis rs7264396 0.635 rs6058365 chr20:34508092 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.94 -0.44 2.7e-17 Total cholesterol levels; LUSC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg22823121 chr1:150693482 HORMAD1 0.5 7.21 0.37 3.67e-12 Melanoma; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg04518342 chr5:131593106 PDLIM4 -0.53 -9.46 -0.46 5.69e-19 Acylcarnitine levels; LUSC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg22834771 chr12:69754056 YEATS4 -0.53 -8.07 -0.4 1.27e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs453301 0.686 rs6601281 chr8:8911004 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.18 -0.41 5.98e-15 Joint mobility (Beighton score); LUSC cis rs3806843 0.932 rs2563256 chr5:140141779 G/T cg19875535 chr5:140030758 IK -0.47 -7.69 -0.39 1.64e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs9300255 0.537 rs1727334 chr12:123714236 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.22 -0.32 1.48e-9 Neutrophil percentage of white cells; LUSC cis rs2629540 0.806 rs10901812 chr10:126419384 A/G cg08799069 chr10:126477246 METTL10 -0.62 -8.81 -0.43 6.71e-17 Cocaine dependence; LUSC cis rs1113500 0.897 rs10785832 chr1:108638899 G/A cg11967332 chr1:108735228 SLC25A24 0.39 5.93 0.31 7.44e-9 Growth-regulated protein alpha levels; LUSC cis rs2274273 0.624 rs7140628 chr14:55760681 A/C cg04306507 chr14:55594613 LGALS3 0.49 10.03 0.48 7.04e-21 Protein biomarker; LUSC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg07952391 chr2:88470173 THNSL2 0.77 6.84 0.35 3.74e-11 Plasma clusterin levels; LUSC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg03609598 chr5:56110824 MAP3K1 -0.41 -5.9 -0.31 8.97e-9 Initial pursuit acceleration; LUSC cis rs2404602 0.692 rs35195096 chr15:76938447 C/T cg26408565 chr15:76604113 ETFA -0.47 -7.42 -0.38 9.75e-13 Blood metabolite levels; LUSC cis rs6430585 0.583 rs73957037 chr2:136588031 C/A cg07169764 chr2:136633963 MCM6 1.09 16.22 0.66 4.72e-44 Corneal structure; LUSC cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg21535247 chr6:8435926 SLC35B3 0.58 9.11 0.45 7.98e-18 Motion sickness; LUSC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg20607287 chr7:12443886 VWDE -0.65 -6.34 -0.33 7.48e-10 Coronary artery disease; LUSC trans rs9467711 0.591 rs34791189 chr6:26035806 G/A cg06753689 chr10:1034030 GTPBP4 -0.6 -5.97 -0.31 6.09e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4906332 1.000 rs34347076 chr14:103955069 G/A cg04998671 chr14:104000505 TRMT61A -0.45 -7.16 -0.36 5.08e-12 Coronary artery disease; LUSC cis rs6754311 0.597 rs6760329 chr2:136544752 A/G cg07169764 chr2:136633963 MCM6 -0.74 -9.97 -0.48 1.19e-20 Mosquito bite size; LUSC cis rs4851254 0.660 rs58683655 chr2:100686519 G/C cg07810366 chr2:100720526 AFF3 -0.46 -6.16 -0.32 2.05e-9 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.7 0.3 2.64e-8 Menopause (age at onset); LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 8.03e-17 Prudent dietary pattern; LUSC cis rs2070488 0.699 rs13064938 chr3:38440237 T/C cg24069376 chr3:38537580 EXOG 0.38 7.34 0.37 1.69e-12 Electrocardiographic conduction measures; LUSC trans rs7248779 0.532 rs10153475 chr19:2413961 G/C cg25835954 chr13:50160062 RCBTB1 0.55 7.81 0.39 7.71e-14 Cortisol levels (saliva); LUSC cis rs2067615 0.524 rs10467029 chr12:107078448 C/T cg15890332 chr12:107067104 RFX4 0.36 6.24 0.32 1.35e-9 Heart rate; LUSC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.06 0.44 1.12e-17 Monocyte percentage of white cells; LUSC cis rs6840360 0.571 rs1822346 chr4:152525303 G/C cg22705602 chr4:152727874 NA -0.33 -6.71 -0.34 8.54e-11 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg09184832 chr6:79620586 NA -0.42 -6.82 -0.35 4.28e-11 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg04455712 chr21:45112962 RRP1B 0.48 9.02 0.44 1.45e-17 Mean corpuscular volume; LUSC cis rs77106637 0.932 rs74439784 chr11:72649396 A/T cg03713592 chr11:72463424 ARAP1 0.74 8.74 0.43 1.12e-16 Type 2 diabetes; LUSC cis rs10979 0.597 rs9484776 chr6:143906325 T/C cg25407410 chr6:143891975 LOC285740 -0.68 -8.33 -0.41 2.16e-15 Hypospadias; LUSC cis rs2885056 0.800 rs8105074 chr19:10708692 A/G cg04833646 chr19:10679720 CDKN2D 1.06 14.03 0.61 1.72e-35 Red cell distribution width; LUSC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.1 16.88 0.68 1.19e-46 Age-related macular degeneration (geographic atrophy); LUSC cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg02175503 chr12:58329896 NA 0.49 7.13 0.36 6.28e-12 Intelligence (multi-trait analysis); LUSC trans rs877282 0.898 rs11253353 chr10:766862 C/A cg13042288 chr15:90349979 ANPEP -0.46 -6.1 -0.32 2.89e-9 Uric acid levels; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg08472276 chr7:1133186 C7orf50;GPER -0.37 -5.97 -0.31 6.16e-9 Longevity;Endometriosis; LUSC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg04287289 chr16:89883240 FANCA 0.78 6.24 0.32 1.29e-9 Skin colour saturation; LUSC cis rs7605827 0.866 rs34815739 chr2:15533375 A/G cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs11583043 1.000 rs17100939 chr1:101443701 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.24 0.32 1.35e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg01849466 chr14:104193079 ZFYVE21 -0.57 -8.44 -0.42 1.01e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs9395066 0.545 rs4714830 chr6:44955528 C/T cg25276700 chr6:44698697 NA 0.29 5.8 0.3 1.53e-8 Height; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg10729496 chr3:10149963 C3orf24 0.51 6.77 0.35 5.8200000000000003e-11 Alzheimer's disease; LUSC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg00784671 chr22:46762841 CELSR1 -0.49 -5.96 -0.31 6.49e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04686114 chr12:57081832 PTGES3 -0.47 -6.23 -0.32 1.41e-9 Bipolar disorder and schizophrenia; LUSC cis rs7617480 0.648 rs6766238 chr3:48801929 G/A cg07636037 chr3:49044803 WDR6 0.9 12.05 0.55 4.99e-28 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7568458 0.837 rs35215812 chr2:85792384 G/A cg02493740 chr2:85810744 VAMP5 -0.33 -5.83 -0.3 1.29e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2404602 0.647 rs12903331 chr15:77168268 C/G cg23625390 chr15:77176239 SCAPER -0.65 -9.96 -0.48 1.21e-20 Blood metabolite levels; LUSC cis rs9479482 1.000 rs11155696 chr6:150357283 G/A cg03788504 chr6:150331562 NA -0.26 -5.84 -0.3 1.22e-8 Alopecia areata; LUSC cis rs16854884 0.586 rs2011080 chr3:143756149 T/G cg06585982 chr3:143692056 C3orf58 0.51 8.25 0.41 3.6e-15 Economic and political preferences (feminism/equality); LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg20607798 chr8:58055168 NA 0.57 5.78 0.3 1.7e-8 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs7656873 chr4:97964668 A/G cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg26395211 chr5:140044315 WDR55 0.46 7.1 0.36 7.64e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg02018176 chr4:1364513 KIAA1530 0.5 8.54 0.42 4.76e-16 Obesity-related traits; LUSC trans rs6951245 1.000 rs80212261 chr7:1114012 C/T cg13565492 chr6:43139072 SRF -0.63 -6.63 -0.34 1.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg05347473 chr6:146136440 FBXO30 0.49 8.19 0.41 5.64e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303401 0.659 rs11079357 chr17:56902778 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.35 0.59 7.08e-33 Cognitive test performance; LUSC cis rs4243830 0.850 rs4434862 chr1:6602241 C/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -10.3 -0.49 8.6e-22 Body mass index; LUSC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg13939156 chr17:80058883 NA -0.33 -6.6 -0.34 1.59e-10 Life satisfaction; LUSC cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.32 -0.37 1.84e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1559088 0.600 rs10423965 chr19:33600319 T/G cg27124370 chr19:33622961 WDR88 0.56 7.97 0.4 2.53e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6121246 0.529 rs6058152 chr20:30178107 G/A cg18721089 chr20:30220636 NA -0.39 -6.15 -0.32 2.2e-9 Mean corpuscular hemoglobin; LUSC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg21433313 chr16:3507492 NAT15 0.41 5.78 0.3 1.69e-8 Body mass index (adult); LUSC cis rs701145 0.878 rs442480 chr3:153992952 T/A cg17054900 chr3:154042577 DHX36 0.84 8.49 0.42 6.84e-16 Coronary artery disease; LUSC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.61 0.62 1.05e-37 Allergic disease (asthma, hay fever or eczema); LUSC cis rs72781680 1.000 rs72781671 chr2:24231123 A/G cg08917208 chr2:24149416 ATAD2B 1.0 10.49 0.5 1.96e-22 Lymphocyte counts; LUSC cis rs7949030 0.754 rs36104523 chr11:62395740 A/T cg11742103 chr11:62369870 EML3;MTA2 -0.48 -8.36 -0.42 1.71e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg15839431 chr19:19639596 YJEFN3 -0.59 -6.2 -0.32 1.62e-9 Bipolar disorder; LUSC cis rs10911232 0.507 rs4483371 chr1:182988352 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.87e-23 Hypertriglyceridemia; LUSC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg18876405 chr7:65276391 NA -0.68 -12.13 -0.55 2.74e-28 Aortic root size; LUSC cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg06028605 chr16:24865363 SLC5A11 0.47 8.5 0.42 6.31e-16 Intelligence (multi-trait analysis); LUSC cis rs9309711 0.961 rs11890651 chr2:3482796 T/G cg10845886 chr2:3471009 TTC15 -0.58 -7.52 -0.38 5.21e-13 Neurofibrillary tangles; LUSC cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg06462663 chr19:18546047 ISYNA1 0.49 8.36 0.42 1.74e-15 Breast cancer; LUSC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg07701084 chr6:150067640 NUP43 0.53 7.93 0.4 3.23e-14 Lung cancer; LUSC cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 8.16e-15 Axial length; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06935581 chr16:451865 DECR2 0.69 5.97 0.31 6.16e-9 Cognitive performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21898799 chr19:49122504 RPL18;SPHK2 -0.41 -6.01 -0.31 4.93e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg12463550 chr7:65579703 CRCP 0.5 7.03 0.36 1.17e-11 Aortic root size; LUSC cis rs2289583 0.642 rs11635266 chr15:75386649 T/C cg10253484 chr15:75165896 SCAMP2 0.41 5.8 0.3 1.51e-8 Systemic lupus erythematosus; LUSC cis rs10892173 0.566 rs12364667 chr11:117675286 A/C cg07621104 chr11:117668040 DSCAML1 0.45 5.92 0.31 8.12e-9 Myopia; LUSC cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg13010199 chr12:38710504 ALG10B 0.48 7.49 0.38 6.31e-13 Morning vs. evening chronotype; LUSC cis rs1210638 0.706 rs2518798 chr22:18970403 T/C cg12798833 chr22:18958832 DGCR5 -0.31 -5.83 -0.3 1.31e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg02574844 chr11:5959923 NA -0.41 -5.82 -0.3 1.4e-8 DNA methylation (variation); LUSC cis rs9814567 0.963 rs36006513 chr3:134291913 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.27 0.32 1.13e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg04518342 chr5:131593106 PDLIM4 -0.36 -6.62 -0.34 1.41e-10 Breast cancer; LUSC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg13206674 chr6:150067644 NUP43 0.61 9.65 0.47 1.4e-19 Lung cancer; LUSC cis rs2204008 0.583 rs12307593 chr12:38317803 A/G cg26384229 chr12:38710491 ALG10B 0.57 8.5 0.42 6.44e-16 Bladder cancer; LUSC trans rs7615952 0.599 rs67566088 chr3:125768973 C/A cg07211511 chr3:129823064 LOC729375 -0.74 -9.62 -0.47 1.65e-19 Blood pressure (smoking interaction); LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg02018176 chr4:1364513 KIAA1530 0.47 8.21 0.41 4.75e-15 Obesity-related traits; LUSC trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7202877 0.706 rs4887813 chr16:75312494 A/G cg04384234 chr16:75411784 CFDP1 -0.66 -8.99 -0.44 1.84e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.81 14.89 0.63 7.94e-39 Total body bone mineral density; LUSC cis rs189798 0.807 rs12785 chr8:8994936 A/T cg15556689 chr8:8085844 FLJ10661 0.47 6.21 0.32 1.59e-9 Myopia (pathological); LUSC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.46 0.46 5.71e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2637266 1.000 rs2395389 chr10:78357701 C/T cg18941641 chr10:78392320 NA 0.38 6.93 0.35 2.18e-11 Pulmonary function; LUSC cis rs9611565 0.649 rs2413659 chr22:42164862 A/G cg03806693 chr22:41940476 POLR3H 0.84 12.06 0.55 4.75e-28 Vitiligo; LUSC cis rs9283706 0.608 rs10065036 chr5:66338084 G/A cg11590213 chr5:66331682 MAST4 0.46 6.77 0.35 5.74e-11 Coronary artery disease; LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg03909863 chr11:638404 DRD4 -0.41 -6.18 -0.32 1.84e-9 Systemic lupus erythematosus; LUSC trans rs72674100 1.000 rs10016008 chr4:97974457 A/G cg16405019 chr1:18959625 PAX7 -0.58 -6.3 -0.33 9.4e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.26 -0.37 2.75e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs30380 0.632 rs26489 chr5:96133427 C/T cg16492584 chr5:96139282 ERAP1 -0.56 -7.56 -0.38 3.96e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs3857536 0.505 rs208459 chr6:66911055 C/T cg07460842 chr6:66804631 NA -0.74 -9.93 -0.48 1.51e-20 Blood trace element (Cu levels); LUSC cis rs72781680 0.752 rs56152044 chr2:23927680 A/G cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.4e-12 Lymphocyte counts; LUSC cis rs11711311 1.000 rs9288983 chr3:113488699 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.92 0.35 2.34e-11 IgG glycosylation; LUSC trans rs9784649 1.000 rs56156666 chr5:24999440 A/T cg08600765 chr20:34638493 LOC647979 -0.53 -6.35 -0.33 6.94e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1215050 0.791 rs1605259 chr4:98799732 T/C cg05340658 chr4:99064831 C4orf37 0.44 7.0 0.36 1.41e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg00814883 chr7:100076585 TSC22D4 -0.73 -9.8 -0.47 4.39e-20 Platelet count; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg15082645 chr12:121148294 UNC119B 0.39 6.16 0.32 2.1e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4481887 0.676 rs1538704 chr1:248523554 C/T cg26353448 chr1:248524236 OR2T4 -0.3 -5.81 -0.3 1.48e-8 Common traits (Other); LUSC cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.54e-17 Motion sickness; LUSC cis rs12208915 0.945 rs12214796 chr6:79561068 T/C cg05283184 chr6:79620031 NA 0.46 5.97 0.31 5.97e-9 Left atrial antero-posterior diameter; LUSC cis rs1348850 0.958 rs11684320 chr2:178456346 T/C cg22681709 chr2:178499509 PDE11A -0.47 -8.36 -0.42 1.68e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9790314 0.502 rs7647118 chr3:161016165 T/C cg03342759 chr3:160939853 NMD3 -0.53 -7.63 -0.39 2.4e-13 Morning vs. evening chronotype; LUSC cis rs2147959 0.941 rs10916317 chr1:228645063 A/G cg18477163 chr1:228402036 OBSCN -0.44 -6.0 -0.31 5.14e-9 Adult asthma; LUSC trans rs2832077 0.943 rs2832084 chr21:30154798 A/G cg14791747 chr16:20752902 THUMPD1 0.71 9.39 0.46 9.69e-19 Cognitive test performance; LUSC cis rs9393777 0.841 rs13191474 chr6:27413345 C/T cg26958806 chr6:27640298 NA 0.71 5.68 0.3 2.92e-8 Intelligence (multi-trait analysis); LUSC cis rs9549260 0.755 rs7338669 chr13:41200091 C/T cg21288729 chr13:41239152 FOXO1 -0.59 -9.21 -0.45 3.57e-18 Red blood cell count; LUSC cis rs12971120 0.891 rs11151961 chr18:72177340 C/T cg25817165 chr18:72167213 CNDP2 -0.71 -8.37 -0.42 1.59e-15 Refractive error; LUSC cis rs9473147 0.503 rs9473123 chr6:47475339 G/A cg12968598 chr6:47444699 CD2AP 0.52 7.9 0.4 4.13e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.31e-41 Bladder cancer; LUSC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg11584989 chr19:19387371 SF4 0.57 6.92 0.35 2.31e-11 Bipolar disorder; LUSC cis rs2439831 0.867 rs11856184 chr15:43919162 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC cis rs12908161 1.000 rs35960805 chr15:85343980 T/G cg17173187 chr15:85201210 NMB 0.48 8.9 0.44 3.51e-17 Schizophrenia; LUSC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg13206674 chr6:150067644 NUP43 0.6 9.7 0.47 9.47e-20 Lung cancer; LUSC cis rs77741769 0.529 rs909053 chr12:121237668 G/A cg02419362 chr12:121203948 SPPL3 0.46 8.54 0.42 4.69e-16 Mean corpuscular volume; LUSC cis rs7954584 0.551 rs1169072 chr12:122401501 C/T cg21171335 chr12:122356390 WDR66 -0.5 -7.37 -0.37 1.35e-12 Mean corpuscular volume; LUSC cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg00012203 chr2:219082015 ARPC2 -0.71 -11.74 -0.54 7.24e-27 Colorectal cancer; LUSC cis rs7605827 0.930 rs1549015 chr2:15616458 T/C cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs9473147 0.516 rs7749167 chr6:47493940 G/A cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7829975 0.681 rs2271342 chr8:8643938 C/T cg15556689 chr8:8085844 FLJ10661 0.64 10.2 0.49 1.92e-21 Mood instability; LUSC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg22800045 chr5:56110881 MAP3K1 0.44 6.14 0.32 2.35e-9 Coronary artery disease; LUSC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg09365446 chr1:150670422 GOLPH3L 0.48 7.2 0.37 4.1e-12 Melanoma; LUSC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg06219351 chr7:158114137 PTPRN2 -0.54 -9.85 -0.47 2.89e-20 Calcium levels; LUSC cis rs4478858 0.698 rs4949385 chr1:31793256 C/T cg00250761 chr1:31883323 NA -0.35 -8.75 -0.43 1.09e-16 Alcohol dependence; LUSC cis rs9325144 0.671 rs7306605 chr12:38730471 C/T cg26384229 chr12:38710491 ALG10B 0.6 9.49 0.46 4.56e-19 Morning vs. evening chronotype; LUSC cis rs17270561 0.578 rs76182885 chr6:25904085 G/C cg16482183 chr6:26056742 HIST1H1C 1.01 12.86 0.58 4.88e-31 Iron status biomarkers; LUSC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg15744005 chr10:104629667 AS3MT -0.28 -5.89 -0.31 9.43e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs1493916 0.905 rs12455290 chr18:31398778 A/G cg15819921 chr19:927150 ARID3A -0.44 -6.54 -0.34 2.29e-10 Life satisfaction; LUSC cis rs4499344 0.604 rs259287 chr19:33164859 C/T cg22980127 chr19:33182716 NUDT19 -0.42 -6.3 -0.33 9.55e-10 Mean platelet volume; LUSC trans rs17742757 0.521 rs2736324 chr8:11328182 C/G cg15556689 chr8:8085844 FLJ10661 0.47 5.99 0.31 5.54e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9325144 0.647 rs12424190 chr12:39111206 A/T cg13010199 chr12:38710504 ALG10B -0.53 -8.23 -0.41 4.11e-15 Morning vs. evening chronotype; LUSC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.95 -0.31 6.75e-9 Tonsillectomy; LUSC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg21644426 chr2:191273491 MFSD6 0.62 9.78 0.47 4.81e-20 Pulse pressure; LUSC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg15857475 chr8:145742913 RECQL4;LRRC14 0.76 13.3 0.59 1.09e-32 Age at first birth; LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg10729496 chr3:10149963 C3orf24 0.55 7.31 0.37 2e-12 Alzheimer's disease; LUSC cis rs12801636 0.512 rs11227247 chr11:65422853 A/C cg27068330 chr11:65405492 SIPA1 0.58 5.73 0.3 2.26e-8 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs1728785 1.000 rs12925177 chr16:68569645 A/G cg02508848 chr16:68573721 ZFP90 0.43 6.01 0.31 4.92e-9 Ulcerative colitis; LUSC cis rs10131894 0.611 rs174995 chr14:75434183 T/C cg08847533 chr14:75593920 NEK9 -0.66 -10.85 -0.51 1.06e-23 Coronary artery disease; LUSC cis rs1538970 0.962 rs3219489 chr1:45797505 C/G cg05343316 chr1:45956843 TESK2 0.58 7.91 0.4 3.73e-14 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11227075 chr10:52750930 PRKG1 0.4 6.3 0.33 9.26e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28655083 0.529 rs285023 chr16:77099783 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.39 6.26 0.32 1.16e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9443189 0.615 rs6453829 chr6:76268509 C/T cg01950844 chr6:76311363 SENP6 0.68 6.95 0.36 1.96e-11 Prostate cancer; LUSC cis rs5009270 0.553 rs2188548 chr7:112235267 C/T cg27282281 chr7:112262583 NA 0.43 5.8 0.3 1.57e-8 Osteoarthritis (hip); LUSC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg19230755 chr7:65878503 NA -0.41 -5.82 -0.3 1.37e-8 Aortic root size; LUSC cis rs1595825 0.732 rs2340687 chr2:198460040 T/G cg00982548 chr2:198649783 BOLL -0.52 -6.36 -0.33 6.8e-10 Ulcerative colitis; LUSC cis rs2413583 0.591 rs12483879 chr22:39719148 C/G cg17798944 chr22:39715225 SNORD43;RPL3 0.73 7.11 0.36 7.08e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg23172400 chr8:95962367 TP53INP1 -0.4 -8.06 -0.4 1.37e-14 Type 2 diabetes; LUSC cis rs782590 0.805 rs782578 chr2:55915904 A/C cg03859395 chr2:55845619 SMEK2 0.85 15.18 0.64 5.99e-40 Metabolic syndrome; LUSC cis rs7177699 0.557 rs55870734 chr15:79117917 A/T cg00540400 chr15:79124168 NA -0.48 -8.43 -0.42 1.04e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg13535736 chr9:111863775 C9orf5 -0.35 -5.79 -0.3 1.66e-8 Menarche (age at onset); LUSC trans rs800082 0.839 rs62275528 chr3:144293687 T/C cg24215973 chr2:240111563 HDAC4 -0.44 -6.61 -0.34 1.49e-10 Smoking behavior; LUSC cis rs2742234 0.590 rs2435339 chr10:43642173 G/C cg15436174 chr10:43711423 RASGEF1A -0.44 -7.36 -0.37 1.49e-12 Hirschsprung disease; LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs4629180 0.540 rs6747670 chr2:102130368 T/C cg04415270 chr2:102091202 RFX8 -0.43 -7.49 -0.38 6.2e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs2839186 0.872 rs13052233 chr21:47707284 G/T cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg02428538 chr16:24856791 SLC5A11 0.52 6.0 0.31 5.28e-9 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.544 rs1790100 chr12:123656725 G/T cg00376283 chr12:123451042 ABCB9 0.66 8.26 0.41 3.5e-15 Neutrophil percentage of white cells; LUSC cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg16230307 chr14:35515116 FAM177A1 0.78 10.0 0.48 8.96e-21 Psoriasis; LUSC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg14830002 chr1:247616686 OR2B11 0.49 7.05 0.36 1.05e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs7914558 0.966 rs746293 chr10:104897254 G/T cg04362960 chr10:104952993 NT5C2 0.6 9.59 0.46 2.18e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7809950 1.000 rs10274041 chr7:107261556 C/T cg23024343 chr7:107201750 COG5 0.54 8.44 0.42 9.52e-16 Coronary artery disease; LUSC cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs9300255 0.770 rs28683528 chr12:123845351 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 5.9 0.31 8.85e-9 Neutrophil percentage of white cells; LUSC cis rs9905704 0.647 rs11659035 chr17:56966052 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -7.41 -0.38 1.02e-12 Testicular germ cell tumor; LUSC cis rs11098499 0.754 rs7672594 chr4:120248543 A/C cg09307838 chr4:120376055 NA 0.69 10.48 0.5 2.02e-22 Corneal astigmatism; LUSC trans rs12165098 0.636 rs4581776 chr18:36747024 G/C cg23858286 chr9:138135095 NA -0.42 -6.14 -0.32 2.28e-9 Sleep duration; LUSC cis rs7178572 0.539 rs12594346 chr15:77671966 A/T cg22256960 chr15:77711686 NA 0.51 7.47 0.38 6.85e-13 Type 2 diabetes; LUSC cis rs7568458 0.846 rs10179195 chr2:85762761 A/G cg23752985 chr2:85803571 VAMP8 0.3 6.37 0.33 6.28e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7258465 1.000 rs8105994 chr19:18593553 A/G cg06462663 chr19:18546047 ISYNA1 0.44 7.24 0.37 3.02e-12 Breast cancer; LUSC cis rs826838 0.967 rs34496261 chr12:39023829 G/A cg26384229 chr12:38710491 ALG10B 0.93 17.84 0.7 1.83e-50 Heart rate; LUSC cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6977660 0.653 rs28537170 chr7:19814239 T/G cg05791153 chr7:19748676 TWISTNB 0.8 8.08 0.4 1.16e-14 Thyroid stimulating hormone; LUSC cis rs243505 0.898 rs243536 chr7:148409941 C/T cg09806900 chr7:148480153 CUL1 0.44 6.37 0.33 6.38e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg03526776 chr6:41159608 TREML2 0.32 6.07 0.32 3.44e-9 Alzheimer's disease (late onset); LUSC cis rs1003719 0.523 rs1063949 chr21:38574675 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.22 -0.49 1.68e-21 Eye color traits; LUSC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg11764359 chr7:65958608 NA 0.68 10.88 0.51 8.15e-24 Aortic root size; LUSC cis rs7312933 0.618 rs7954523 chr12:42681508 A/G cg01256987 chr12:42539512 GXYLT1 -0.41 -7.56 -0.38 3.98e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg16405210 chr4:1374714 KIAA1530 0.55 8.87 0.44 4.49e-17 Obesity-related traits; LUSC cis rs9309473 0.687 rs6706235 chr2:73613558 C/G cg20560298 chr2:73613845 ALMS1 -0.62 -9.47 -0.46 5.11e-19 Metabolite levels; LUSC cis rs730566 1.000 rs730566 chr3:48487048 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.42 -7.04 -0.36 1.08e-11 Prion diseases; LUSC trans rs7737355 1.000 rs6876350 chr5:130604109 G/T cg07715041 chr7:99302981 CYP3A7 -0.38 -6.11 -0.32 2.82e-9 Life satisfaction; LUSC trans rs11098499 0.863 rs10013305 chr4:120450424 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.79 0.43 8.2e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs1865760 0.865 rs9393677 chr6:25945815 G/A cg16482183 chr6:26056742 HIST1H1C 0.47 6.95 0.36 1.89e-11 Height; LUSC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg09796270 chr17:17721594 SREBF1 -0.42 -7.3 -0.37 2.11e-12 Total body bone mineral density; LUSC cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg16586182 chr3:47516702 SCAP 0.52 8.13 0.41 8.41e-15 Colorectal cancer; LUSC cis rs12530134 0.519 rs3920484 chr6:170746081 A/G cg16453901 chr6:170730693 NA -0.93 -6.17 -0.32 1.97e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg18252515 chr7:66147081 NA 1.2 13.62 0.6 6.4e-34 Diabetic kidney disease; LUSC trans rs61931739 0.817 rs2636084 chr12:34130210 G/A cg26384229 chr12:38710491 ALG10B 0.57 9.05 0.44 1.16e-17 Morning vs. evening chronotype; LUSC cis rs4969178 0.645 rs4490057 chr17:76375095 C/T cg05887092 chr17:76393375 PGS1 -0.58 -11.14 -0.52 9.76e-25 HDL cholesterol levels; LUSC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg02807482 chr3:125708958 NA -0.52 -6.56 -0.34 2.03e-10 Blood pressure (smoking interaction); LUSC cis rs7223966 1.000 rs9909992 chr17:61731931 G/A cg00945038 chr17:61921165 SMARCD2 0.38 5.67 0.3 3.01e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs11098499 0.731 rs9995026 chr4:120490499 T/A cg09307838 chr4:120376055 NA 0.74 10.76 0.51 2.3e-23 Corneal astigmatism; LUSC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg15556689 chr8:8085844 FLJ10661 0.75 12.3 0.56 5.97e-29 Systolic blood pressure; LUSC cis rs1670533 0.932 rs610218 chr4:1080083 C/G cg27284194 chr4:1044797 NA 0.59 8.84 0.44 5.8e-17 Recombination rate (females); LUSC cis rs3136441 1.000 rs4752947 chr11:46901156 A/T cg01183595 chr11:46746236 F2 0.38 5.67 0.3 3.12e-8 HDL cholesterol; LUSC cis rs79387448 0.564 rs77375846 chr2:103155075 T/C cg09003973 chr2:102972529 NA 1.0 9.4 0.46 8.76e-19 Gut microbiota (bacterial taxa); LUSC cis rs6964587 0.740 rs2020360 chr7:91439506 G/C cg22709100 chr7:91322751 NA 0.46 6.71 0.34 8.29e-11 Breast cancer; LUSC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg16414030 chr3:133502952 NA -0.38 -6.04 -0.31 4.16e-9 Iron status biomarkers; LUSC cis rs1865760 0.566 rs7772312 chr6:26049616 G/C cg16482183 chr6:26056742 HIST1H1C 0.53 7.81 0.39 7.32e-14 Height; LUSC cis rs10883723 0.962 rs1056740 chr10:104236552 C/T cg05855489 chr10:104503620 C10orf26 -0.69 -9.87 -0.48 2.54e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11711311 0.955 rs12636536 chr3:113474226 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.71 0.34 8.49e-11 IgG glycosylation; LUSC cis rs977987 0.843 rs2059256 chr16:75395835 G/T cg03315344 chr16:75512273 CHST6 0.53 10.39 0.49 4.42e-22 Dupuytren's disease; LUSC cis rs2932538 0.922 rs7527076 chr1:113150481 G/A cg22162597 chr1:113214053 CAPZA1 0.69 9.99 0.48 9.74e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg07395648 chr5:131743802 NA 0.4 5.82 0.3 1.34e-8 Breast cancer; LUSC cis rs9902453 0.765 rs3102562 chr17:28040403 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.19 0.52 6.82e-25 Coffee consumption (cups per day); LUSC cis rs34779708 0.898 rs4934695 chr10:35280605 C/T cg03585969 chr10:35415529 CREM 0.65 9.25 0.45 2.78e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7582180 0.629 rs13031508 chr2:100952757 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.75 0.3 2.06e-8 Intelligence (multi-trait analysis); LUSC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg04053776 chr11:6947353 ZNF215 0.53 7.65 0.39 2.17e-13 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg11905131 chr22:24372483 LOC391322 -0.57 -9.39 -0.46 9.43e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg00933542 chr6:150070202 PCMT1 0.3 6.18 0.32 1.83e-9 Lung cancer; LUSC cis rs826838 0.967 rs11168985 chr12:39045983 A/C cg26384229 chr12:38710491 ALG10B -0.9 -16.53 -0.67 2.76e-45 Heart rate; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.38 0.42 1.54e-15 Prudent dietary pattern; LUSC trans rs73191547 0.501 rs6986885 chr8:9978471 G/A cg06636001 chr8:8085503 FLJ10661 0.43 6.03 0.31 4.23e-9 Schizophrenia; LUSC cis rs7681440 0.583 rs2737035 chr4:90777213 C/T cg06632027 chr4:90757378 SNCA -0.37 -5.75 -0.3 1.99e-8 Dementia with Lewy bodies; LUSC cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.09 -0.52 1.52e-24 Mean corpuscular volume; LUSC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 7.96 0.4 2.74e-14 Axial length; LUSC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg05776053 chr2:74358815 NA 0.46 6.7 0.34 8.91e-11 Gestational age at birth (maternal effect); LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg21724239 chr8:58056113 NA 0.77 9.21 0.45 3.76e-18 Developmental language disorder (linguistic errors); LUSC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg13114125 chr14:105738426 BRF1 -0.9 -15.55 -0.65 2.03e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs1865760 1.000 rs1865760 chr6:25916979 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.78 0.35 5.42e-11 Height; LUSC trans rs61931739 0.963 rs1817759 chr12:34101521 G/A cg13010199 chr12:38710504 ALG10B -0.41 -6.08 -0.32 3.25e-9 Morning vs. evening chronotype; LUSC cis rs61931739 0.591 rs4931764 chr12:33979423 A/G cg06521331 chr12:34319734 NA -0.41 -6.81 -0.35 4.58e-11 Morning vs. evening chronotype; LUSC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg16928487 chr17:17741425 SREBF1 -0.44 -8.59 -0.43 3.27e-16 Total body bone mineral density; LUSC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg07701084 chr6:150067640 NUP43 0.53 7.95 0.4 2.83e-14 Lung cancer; LUSC cis rs1559088 0.744 rs12972060 chr19:33537096 C/T cg17764715 chr19:33622953 WDR88 -0.48 -6.55 -0.34 2.14e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg21951975 chr1:209979733 IRF6 0.54 6.71 0.34 8.37e-11 Coronary artery disease; LUSC cis rs11214589 0.651 rs12360992 chr11:113262900 A/C cg14159747 chr11:113255604 NA 0.29 7.56 0.38 3.98e-13 Neuroticism; LUSC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg11663144 chr21:46675770 NA -0.42 -7.34 -0.37 1.59e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7709377 0.574 rs1508875 chr5:115496470 C/T cg23108291 chr5:115420582 COMMD10 -0.42 -6.03 -0.31 4.4e-9 Metabolite levels (X-11787); LUSC cis rs12594515 1.000 rs12906442 chr15:45985254 C/A cg06207120 chr15:45996521 NA 0.39 6.01 0.31 4.87e-9 Waist circumference;Weight; LUSC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg20476274 chr7:133979776 SLC35B4 0.82 14.95 0.63 4.64e-39 Mean platelet volume; LUSC cis rs2235649 0.833 rs2011088 chr16:1850091 T/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.1 -0.32 2.85e-9 Blood metabolite levels; LUSC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs739496 1.000 rs739496 chr12:111887659 A/G cg10833066 chr12:111807467 FAM109A 0.31 5.72 0.3 2.41e-8 Platelet count; LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.872 rs10863146 chr12:86408326 C/G cg02569458 chr12:86230093 RASSF9 0.39 6.2 0.32 1.63e-9 Major depressive disorder; LUSC cis rs36093844 0.800 rs17817331 chr11:85595338 A/G cg25872744 chr11:85566296 CCDC83 0.45 6.01 0.31 4.84e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs72720396 0.789 rs12048450 chr1:91199660 G/A cg13456504 chr1:91191583 NA 0.56 8.02 0.4 1.86e-14 Morning vs. evening chronotype;Chronotype; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg08200582 chr11:442649 ANO9 -0.52 -5.72 -0.3 2.43e-8 Body mass index; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -7.66 -0.39 1.97e-13 Longevity;Endometriosis; LUSC cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg11530693 chr1:120165357 ZNF697 0.69 10.79 0.51 1.79e-23 Systemic lupus erythematosus; LUSC cis rs1729951 0.575 rs16844362 chr3:136704008 T/C cg21827317 chr3:136751795 NA 0.39 7.12 0.36 6.45e-12 Neuroticism; LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg26784012 chr10:32216390 ARHGAP12 0.45 7.59 0.38 3.19e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4319547 0.695 rs10773152 chr12:122910180 T/C cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.4 -0.42 1.26e-15 Body mass index; LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg16405210 chr4:1374714 KIAA1530 -0.59 -9.48 -0.46 5.04e-19 Longevity; LUSC trans rs1005277 0.522 rs7072977 chr10:37940440 C/A cg17830980 chr10:43048298 ZNF37B -0.44 -7.05 -0.36 1.06e-11 Extrinsic epigenetic age acceleration; LUSC cis rs11711311 0.955 rs9823423 chr3:113419741 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.54 0.34 2.25e-10 IgG glycosylation; LUSC cis rs7824557 0.701 rs2060465 chr8:11162609 T/C cg21775007 chr8:11205619 TDH 0.71 11.36 0.53 1.72e-25 Retinal vascular caliber; LUSC cis rs2188554 0.583 rs2213958 chr7:117241394 A/T cg10524701 chr7:117356490 CTTNBP2 0.4 5.75 0.3 1.99e-8 Esophageal adenocarcinoma; LUSC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg23601095 chr6:26197514 HIST1H3D 0.72 7.33 0.37 1.71e-12 Gout;Renal underexcretion gout; LUSC cis rs10465746 0.967 rs12732697 chr1:84349283 A/G cg10977910 chr1:84465055 TTLL7 0.44 6.29 0.33 9.9e-10 Obesity-related traits; LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg24675658 chr1:53192096 ZYG11B 0.57 8.92 0.44 3.22e-17 Monocyte count; LUSC cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg10978503 chr1:24200527 CNR2 -0.53 -12.99 -0.58 1.6e-31 Immature fraction of reticulocytes; LUSC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg26116260 chr4:7069785 GRPEL1 1.16 18.16 0.7 9.53e-52 Monocyte percentage of white cells; LUSC cis rs17685 0.725 rs7795291 chr7:75725206 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.04 -0.4 1.62e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9535307 0.929 rs942032 chr13:50251145 T/G cg04663916 chr13:50265991 EBPL 0.49 5.7 0.3 2.63e-8 Obesity-related traits; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg21782813 chr7:2030301 MAD1L1 0.53 9.21 0.45 3.7e-18 Bipolar disorder and schizophrenia; LUSC cis rs2348418 0.715 rs1355471 chr12:28721725 A/G cg13890972 chr12:28721907 NA 0.38 6.88 0.35 2.92e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs3087591 1.000 rs2854322 chr17:29699416 C/T cg24425628 chr17:29625626 OMG;NF1 0.6 8.78 0.43 8.55e-17 Hip circumference; LUSC cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg00012203 chr2:219082015 ARPC2 -0.7 -11.59 -0.54 2.53e-26 Colorectal cancer; LUSC cis rs61990749 0.544 rs176962 chr14:78185510 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.41 0.33 4.9e-10 Fibroblast growth factor basic levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg23037186 chr1:16971262 MST1P2 0.38 5.95 0.31 6.94e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.42 6.52 0.34 2.66e-10 Menarche (age at onset); LUSC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.44 6.2 0.32 1.71e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -6.08 -0.32 3.33e-9 Schizophrenia; LUSC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.34 0.67 1.68e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg18252515 chr7:66147081 NA -1.23 -13.28 -0.59 1.37e-32 Diabetic kidney disease; LUSC cis rs8062405 0.723 rs4788079 chr16:28559363 C/A cg16576597 chr16:28551801 NUPR1 0.33 6.63 0.34 1.3100000000000001e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2274273 0.870 rs7158768 chr14:55763612 A/C cg04306507 chr14:55594613 LGALS3 0.56 13.23 0.59 2.05e-32 Protein biomarker; LUSC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.53 -7.46 -0.38 7.4e-13 Mean platelet volume; LUSC cis rs9467711 0.538 rs35934643 chr6:26355094 G/A cg09904177 chr6:26538194 HMGN4 -0.7 -6.85 -0.35 3.65e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg20283391 chr11:68216788 NA -0.58 -8.19 -0.41 5.48e-15 Total body bone mineral density; LUSC cis rs807669 0.548 rs723414 chr22:19185736 G/A cg02655711 chr22:19163373 SLC25A1 0.69 12.78 0.57 1.04e-30 Metabolite levels; LUSC cis rs3760982 0.585 rs4803659 chr19:44290235 C/T cg11993925 chr19:44307056 LYPD5 0.35 7.57 0.38 3.76e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg16666935 chr13:31736119 HSPH1 -0.48 -5.99 -0.31 5.3300000000000004e-09 Neuroticism; LUSC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg23711669 chr6:146136114 FBXO30 0.9 16.98 0.68 4.57e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg08392591 chr16:89556376 ANKRD11 0.47 7.23 0.37 3.39e-12 Multiple myeloma (IgH translocation); LUSC trans rs6502050 0.777 rs6502058 chr17:80082500 A/C cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs4595586 0.545 rs12809435 chr12:39404341 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.22 -0.32 1.47e-9 Morning vs. evening chronotype; LUSC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg12516959 chr21:47718080 NA -0.37 -6.11 -0.32 2.85e-9 Testicular germ cell tumor; LUSC cis rs9517320 0.515 rs1107379 chr13:99198921 C/T cg20487152 chr13:99095054 FARP1 -0.41 -6.96 -0.36 1.78e-11 Longevity; LUSC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg26314531 chr2:26401878 FAM59B -0.68 -9.1 -0.45 8.35e-18 Gut microbiome composition (summer); LUSC cis rs1113500 0.933 rs4517375 chr1:108638330 A/C cg11967332 chr1:108735228 SLC25A24 -0.39 -6.01 -0.31 4.83e-9 Growth-regulated protein alpha levels; LUSC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg14552801 chr7:65878734 NA -0.44 -6.18 -0.32 1.85e-9 Aortic root size; LUSC cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg13010199 chr12:38710504 ALG10B 0.66 9.86 0.47 2.65e-20 Bladder cancer; LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg08859206 chr1:53392774 SCP2 0.51 8.67 0.43 1.96e-16 Monocyte count; LUSC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg18512352 chr11:47633146 NA -0.48 -9.57 -0.46 2.51e-19 Subjective well-being; LUSC cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.46 -0.42 8.29e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -11.13 -0.52 1.13e-24 Chronic sinus infection; LUSC cis rs9309473 0.519 rs13027816 chr2:73897691 C/T cg20560298 chr2:73613845 ALMS1 0.47 7.01 0.36 1.3e-11 Metabolite levels; LUSC cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.27 -0.41 3.16e-15 Schizophrenia; LUSC trans rs2204008 0.774 rs7959048 chr12:37948276 T/A cg06521331 chr12:34319734 NA -0.4 -6.17 -0.32 2e-9 Bladder cancer; LUSC cis rs7712401 0.601 rs390234 chr5:122331523 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.2 -0.45 4.07e-18 Mean platelet volume; LUSC cis rs61931739 0.500 rs11053066 chr12:34185318 G/A cg06521331 chr12:34319734 NA -0.45 -7.38 -0.37 1.29e-12 Morning vs. evening chronotype; LUSC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg18230493 chr5:56204884 C5orf35 0.73 11.56 0.53 3.12e-26 Initial pursuit acceleration; LUSC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.15 0.41 7.33e-15 Homoarginine levels; LUSC cis rs858239 0.601 rs3735228 chr7:23170427 T/G cg23682824 chr7:23144976 KLHL7 0.39 5.67 0.3 3.11e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7584330 0.554 rs77648388 chr2:238431832 G/C cg16989719 chr2:238392110 NA -0.52 -6.75 -0.35 6.41e-11 Prostate cancer; LUSC cis rs1577917 1.000 rs12213149 chr6:86668644 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.84 -0.35 3.68e-11 Response to antipsychotic treatment; LUSC cis rs231513 0.954 rs231493 chr17:41976998 G/C cg26893861 chr17:41843967 DUSP3 -0.51 -6.06 -0.31 3.74e-9 Cognitive function; LUSC cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.51 0.5 1.69e-22 Schizophrenia; LUSC cis rs6598955 0.671 rs12141563 chr1:26589636 A/G cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg05393297 chr12:53359155 NA -0.7 -10.51 -0.5 1.65e-22 Cancer (pleiotropy); LUSC cis rs911119 0.955 rs6114201 chr20:23607231 T/A cg16589663 chr20:23618590 CST3 0.57 6.86 0.35 3.3e-11 Chronic kidney disease; LUSC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg08847533 chr14:75593920 NEK9 -0.8 -13.47 -0.59 2.46e-33 Height; LUSC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg01579765 chr21:45077557 HSF2BP -0.56 -11.65 -0.54 1.43e-26 Mean corpuscular volume; LUSC cis rs57920188 0.535 rs10915664 chr1:4093700 G/A cg20703997 chr1:4087676 NA 0.56 7.97 0.4 2.62e-14 Interleukin-17 levels; LUSC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg22166914 chr1:53195759 ZYG11B 0.56 9.03 0.44 1.44e-17 Monocyte count; LUSC cis rs4722585 0.533 rs757371 chr7:26199207 A/G cg07876897 chr7:26191696 NFE2L3 0.45 6.64 0.34 1.3100000000000001e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg04455712 chr21:45112962 RRP1B 0.46 8.87 0.44 4.59e-17 Mean corpuscular volume; LUSC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg06008330 chr7:65541103 ASL 0.42 6.55 0.34 2.19e-10 Aortic root size; LUSC cis rs9467773 0.869 rs742090 chr6:26415637 A/C cg11502198 chr6:26597334 ABT1 -0.5 -7.25 -0.37 2.91e-12 Intelligence (multi-trait analysis); LUSC cis rs4319547 0.774 rs7959238 chr12:123131498 A/T cg05707623 chr12:122985044 ZCCHC8 -0.55 -7.56 -0.38 3.86e-13 Body mass index; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs6433857 0.536 rs1971134 chr2:181351532 G/A cg23363182 chr2:181467187 NA -0.44 -7.05 -0.36 1.04e-11 Body mass index; LUSC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs10089 0.953 rs1012851 chr5:127360241 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 11.78 0.54 5.23e-27 Ileal carcinoids; LUSC cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg05347473 chr6:146136440 FBXO30 0.58 10.14 0.49 3.06e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg01802117 chr1:53393560 SCP2 -0.42 -7.07 -0.36 9.26e-12 Monocyte count; LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg22963979 chr7:1858916 MAD1L1 -0.58 -9.03 -0.44 1.39e-17 Bipolar disorder and schizophrenia; LUSC cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.35 0.37 1.53e-12 Cognitive function; LUSC cis rs7659604 0.502 rs10212738 chr4:122675724 G/A cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs897984 0.542 rs7294 chr16:31102321 A/G cg02466173 chr16:30829666 NA 0.48 8.99 0.44 1.86e-17 Dementia with Lewy bodies; LUSC cis rs62458065 0.513 rs10265319 chr7:32571564 A/C cg20159608 chr7:32802032 NA -0.71 -9.23 -0.45 3.21e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg18099408 chr3:52552593 STAB1 0.35 6.0 0.31 5.23e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7149337 0.805 rs2999355 chr14:51607084 A/G cg23942311 chr14:51606299 NA 0.49 11.44 0.53 8.76e-26 Cancer; LUSC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.57 -0.34 1.89e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg19418458 chr7:158789849 NA -0.65 -11.12 -0.52 1.16e-24 Facial morphology (factor 20); LUSC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg03929089 chr4:120376271 NA -0.94 -14.98 -0.63 3.56e-39 Coronary artery disease; LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg24060327 chr5:131705240 SLC22A5 -0.66 -11.55 -0.53 3.41e-26 Breast cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06622468 chr19:10491460 TYK2 -0.47 -6.4 -0.33 5.36e-10 Bipolar disorder and schizophrenia; LUSC cis rs909341 0.909 rs1151622 chr20:62365556 A/G cg09650180 chr20:62225654 GMEB2 -0.45 -5.81 -0.3 1.48e-8 Atopic dermatitis; LUSC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg13683864 chr3:40499215 RPL14 -1.2 -18.3 -0.71 2.6e-52 Renal cell carcinoma; LUSC cis rs4706831 0.625 rs638056 chr6:80980808 G/A cg08355045 chr6:80787529 NA -0.4 -6.9 -0.35 2.66e-11 Joint mobility (Beighton score); LUSC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7107174 0.892 rs3018313 chr11:77989644 C/T cg02023728 chr11:77925099 USP35 0.48 6.81 0.35 4.5e-11 Testicular germ cell tumor; LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg01802117 chr1:53393560 SCP2 -0.38 -6.21 -0.32 1.6e-9 Monocyte count; LUSC trans rs61931739 0.500 rs6416261 chr12:34540377 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06138422 chr12:133338013 ANKLE2 -0.48 -6.32 -0.33 8.33e-10 Bipolar disorder and schizophrenia; LUSC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg03609598 chr5:56110824 MAP3K1 -0.42 -5.97 -0.31 5.96e-9 Initial pursuit acceleration; LUSC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg23758822 chr17:41437982 NA 1.01 19.41 0.73 1.04e-56 Menopause (age at onset); LUSC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg23982607 chr1:1823379 GNB1 -0.71 -14.64 -0.63 7.87e-38 Body mass index; LUSC cis rs4629180 0.917 rs7560926 chr2:102125098 C/A cg01388757 chr2:102091195 RFX8 0.48 7.64 0.39 2.39e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7605827 0.897 rs6431698 chr2:15540156 G/C cg19274914 chr2:15703543 NA 0.46 8.96 0.44 2.28e-17 Educational attainment (years of education); LUSC cis rs6500602 0.647 rs1659497 chr16:4594635 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.46 -6.16 -0.32 2.11e-9 Schizophrenia; LUSC trans rs7615952 0.515 rs4441610 chr3:125681307 C/G cg07211511 chr3:129823064 LOC729375 -0.75 -10.4 -0.49 3.9e-22 Blood pressure (smoking interaction); LUSC cis rs9831754 1.000 rs112170848 chr3:78359996 G/A cg06138941 chr3:78371609 NA -0.76 -10.05 -0.48 6.05e-21 Calcium levels; LUSC cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg16482183 chr6:26056742 HIST1H1C 0.47 6.9 0.35 2.61e-11 Height; LUSC cis rs2718798 1 rs2718798 chr3:133492088 A/C cg08048268 chr3:133502702 NA -0.37 -7.04 -0.36 1.12e-11 Ankle injury; LUSC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg05623727 chr3:50126028 RBM5 0.31 5.81 0.3 1.43e-8 Intelligence (multi-trait analysis); LUSC cis rs9549367 0.789 rs9549365 chr13:113907391 C/T cg18105134 chr13:113819100 PROZ 0.63 9.31 0.45 1.71e-18 Platelet distribution width; LUSC cis rs9300255 0.568 rs3018098 chr12:123654812 T/C cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.23 -0.32 1.4e-9 Neutrophil percentage of white cells; LUSC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg13206674 chr6:150067644 NUP43 0.61 9.82 0.47 3.55e-20 Lung cancer; LUSC cis rs12908161 1.000 rs12908161 chr15:85207825 A/G cg17173187 chr15:85201210 NMB 0.53 9.95 0.48 1.3e-20 Schizophrenia; LUSC cis rs9323205 0.871 rs8008599 chr14:51670057 A/G cg23942311 chr14:51606299 NA 0.41 8.06 0.4 1.39e-14 Cancer; LUSC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg06238570 chr21:40685208 BRWD1 0.49 7.54 0.38 4.47e-13 Cognitive function; LUSC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg05623727 chr3:50126028 RBM5 -0.33 -6.11 -0.32 2.72e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg08677398 chr8:58056175 NA 0.52 6.08 0.32 3.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7759001 0.857 rs10807021 chr6:27356925 T/G cg18711553 chr6:27366782 ZNF391 0.39 5.78 0.3 1.73e-8 Glomerular filtration rate (creatinine); LUSC cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg24450063 chr1:156163899 SLC25A44 1.18 30.04 0.85 5.97e-97 Testicular germ cell tumor; LUSC cis rs7582180 0.790 rs4851288 chr2:100920451 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.51 -0.42 6.11e-16 Intelligence (multi-trait analysis); LUSC cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14442939 chr10:27389572 ANKRD26 0.9 9.51 0.46 3.81e-19 Breast cancer; LUSC cis rs9527 0.615 rs9733635 chr10:104711940 G/A cg08330031 chr10:104623503 C10orf32 0.31 5.67 0.3 3.04e-8 Arsenic metabolism; LUSC cis rs11711311 0.911 rs3773681 chr3:113523901 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.82 -0.3 1.37e-8 IgG glycosylation; LUSC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg24209194 chr3:40518798 ZNF619 0.44 6.07 0.31 3.56e-9 Renal cell carcinoma; LUSC cis rs7180079 1.000 rs55700118 chr15:64529455 G/T cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs9677476 0.908 rs7598478 chr2:232115887 C/T cg07929768 chr2:232055508 NA 0.31 5.78 0.3 1.7e-8 Food antigen IgG levels; LUSC cis rs9649213 0.533 rs62478235 chr7:98030349 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.77 -10.87 -0.51 8.9e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs4812048 0.793 rs7266693 chr20:57593158 T/C cg14073986 chr20:57617431 SLMO2 0.67 6.45 0.33 3.94e-10 Mean platelet volume; LUSC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg21856205 chr7:94953877 PON1 -0.35 -5.73 -0.3 2.26e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9987353 0.566 rs13260067 chr8:9071033 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.84 -0.35 3.85e-11 Recombination measurement; LUSC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg09034736 chr1:150693464 HORMAD1 0.44 6.16 0.32 2.05e-9 Melanoma; LUSC cis rs7561273 0.609 rs6545285 chr2:24340029 T/C cg06627628 chr2:24431161 ITSN2 -0.51 -6.84 -0.35 3.83e-11 Quantitative traits; LUSC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.8 11.79 0.54 4.55e-27 Cognitive test performance; LUSC cis rs7178572 0.568 rs12916731 chr15:77507021 C/T cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs68170813 0.652 rs8180747 chr7:107106308 T/C cg02696742 chr7:106810147 HBP1 -0.65 -8.5 -0.42 6.49e-16 Coronary artery disease; LUSC cis rs75804782 0.641 rs56134361 chr2:239318905 A/G cg18131467 chr2:239335373 ASB1 -0.74 -6.64 -0.34 1.28e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.16 0.45 5.34e-18 Prudent dietary pattern; LUSC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg09455208 chr3:40491958 NA 0.58 10.25 0.49 1.31e-21 Renal cell carcinoma; LUSC trans rs2898290 0.622 rs978802 chr8:11343278 A/T cg15556689 chr8:8085844 FLJ10661 -0.53 -8.32 -0.41 2.34e-15 Systolic blood pressure; LUSC trans rs11098499 0.909 rs35165976 chr4:120325630 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC trans rs11098499 0.863 rs3775848 chr4:120447724 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.59 0.38 3.3e-13 Corneal astigmatism; LUSC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg16447950 chr5:562315 NA -0.59 -7.01 -0.36 1.29e-11 Lung disease severity in cystic fibrosis; LUSC cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg13683864 chr3:40499215 RPL14 -0.97 -16.59 -0.67 1.71e-45 Renal cell carcinoma; LUSC cis rs6504663 0.596 rs7208018 chr17:48557863 C/T cg22571038 chr17:48585470 MYCBPAP -0.48 -6.19 -0.32 1.78e-9 Visceral fat; LUSC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01272058 chr19:40926777 NA 0.47 6.99 0.36 1.5e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg09904177 chr6:26538194 HMGN4 -0.39 -5.69 -0.3 2.76e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7428 0.527 rs3184780 chr2:85549547 C/T cg24342717 chr2:85555507 TGOLN2 -0.74 -11.93 -0.55 1.44e-27 Ear protrusion; LUSC cis rs2692947 0.759 rs11687113 chr2:96658588 A/G cg22654517 chr2:96458247 NA 0.31 6.01 0.31 4.89e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs3858526 0.834 rs7129481 chr11:5991114 G/T cg05234568 chr11:5960015 NA -0.61 -8.56 -0.42 4.04e-16 DNA methylation (variation); LUSC trans rs72674100 1.000 rs4075858 chr4:97991815 A/G cg16405019 chr1:18959625 PAX7 0.65 6.78 0.35 5.33e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4803468 1.000 rs4803468 chr19:41922352 A/G cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.41 5.66 0.3 3.22e-8 Height; LUSC cis rs713477 0.967 rs10150596 chr14:55916167 A/G cg13175173 chr14:55914753 NA 0.3 6.42 0.33 4.74e-10 Pediatric bone mineral content (femoral neck); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23593958 chr10:35415966 CREM -0.49 -6.11 -0.32 2.72e-9 Bipolar disorder and schizophrenia; LUSC cis rs8072100 0.666 rs6503804 chr17:45772447 G/A cg08085267 chr17:45401833 C17orf57 -0.46 -6.69 -0.34 9.41e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.39 0.46 9.37e-19 Bipolar disorder; LUSC cis rs12477438 0.765 rs13390672 chr2:99589829 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.75 -0.51 2.45e-23 Chronic sinus infection; LUSC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg12311346 chr5:56204834 C5orf35 0.56 8.62 0.43 2.71e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs400736 0.576 rs10864328 chr1:8164456 G/C cg25007680 chr1:8021821 PARK7 -0.41 -6.15 -0.32 2.27e-9 Response to antidepressants and depression; LUSC cis rs10832963 1.000 rs2084220 chr11:18656932 C/T cg09201001 chr11:18656081 SPTY2D1 0.92 15.2 0.64 4.91e-40 Breast cancer; LUSC cis rs9790314 1.000 rs6765269 chr3:160948542 T/C cg03342759 chr3:160939853 NMD3 -0.49 -8.19 -0.41 5.43e-15 Morning vs. evening chronotype; LUSC cis rs7210086 0.768 rs4072716 chr17:70640933 T/C cg04206342 chr17:70636940 NA -0.35 -5.82 -0.3 1.4e-8 Ulcerative colitis; LUSC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg11189052 chr15:85197271 WDR73 -0.63 -9.89 -0.48 2.15e-20 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15942720 chr14:51706980 TMX1 -0.4 -5.99 -0.31 5.53e-9 Electrocardiographic conduction measures; LUSC cis rs7927592 0.913 rs4988291 chr11:68381607 G/A cg01657329 chr11:68192670 LRP5 -0.4 -5.76 -0.3 1.92e-8 Total body bone mineral density; LUSC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg25019033 chr10:957182 NA -0.5 -6.2 -0.32 1.63e-9 Eosinophil percentage of granulocytes; LUSC cis rs7923452 0.688 rs117895480 chr10:30788921 A/G cg18806716 chr10:30721971 MAP3K8 0.57 6.27 0.32 1.14e-9 Itch intensity from mosquito bite; LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.38 6.18 0.32 1.9e-9 Electroencephalogram traits; LUSC cis rs1788820 0.917 rs1788762 chr18:21132571 G/C cg14672496 chr18:21087552 C18orf8 0.4 6.53 0.34 2.4e-10 Body mass index; LUSC trans rs61931739 1.000 rs1852223 chr12:34013251 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.86 -0.4 5.34e-14 Morning vs. evening chronotype; LUSC cis rs4243830 0.850 rs10746502 chr1:6607199 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.82 -10.2 -0.49 1.94e-21 Body mass index; LUSC cis rs67311347 0.577 rs2887951 chr3:40282104 C/G cg09455208 chr3:40491958 NA 0.45 8.07 0.4 1.25e-14 Renal cell carcinoma; LUSC cis rs738322 0.805 rs2016755 chr22:38539604 A/G cg25457927 chr22:38595422 NA -0.4 -7.86 -0.39 5.5e-14 Cutaneous nevi; LUSC cis rs4631830 0.863 rs2926494 chr10:51517356 T/C cg10326726 chr10:51549505 MSMB -0.35 -5.81 -0.3 1.42e-8 Prostate-specific antigen levels; LUSC cis rs10464366 0.746 rs4723821 chr7:39141532 A/G cg20302533 chr7:39170763 POU6F2 0.51 7.91 0.4 3.72e-14 IgG glycosylation; LUSC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg05805236 chr11:65401703 PCNXL3 0.37 5.89 0.31 9.23e-9 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs2197308 0.765 rs12824529 chr12:37931656 T/C cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.6 0.85 2.14e-95 Chronic sinus infection; LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg18099408 chr3:52552593 STAB1 0.41 7.1 0.36 7.57e-12 Bipolar disorder; LUSC cis rs12476592 0.602 rs10469945 chr2:63816776 T/C cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs1009647 0.645 rs17742719 chr14:55855596 A/C cg04306507 chr14:55594613 LGALS3 -0.4 -6.28 -0.32 1.08e-9 Testicular germ cell tumor; LUSC cis rs57920188 0.585 rs12117500 chr1:4072315 G/A cg20703997 chr1:4087676 NA 0.6 8.35 0.42 1.8e-15 Interleukin-17 levels; LUSC cis rs10203711 0.933 rs11695877 chr2:239585797 T/A cg14580085 chr2:239553406 NA 0.39 6.47 0.33 3.56e-10 Lobe attachment (rater-scored or self-reported); LUSC trans rs72674100 1.000 rs28483048 chr4:97990804 C/A cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9733 0.566 rs878471 chr1:150547747 G/A cg13175981 chr1:150552382 MCL1 0.47 6.49 0.33 3.14e-10 Tonsillectomy; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg22470056 chr3:49947811 MON1A -0.35 -6.05 -0.31 3.89e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.62e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg07936489 chr17:37558343 FBXL20 0.72 9.96 0.48 1.28e-20 Glomerular filtration rate (creatinine); LUSC cis rs73206853 0.563 rs73194050 chr12:111200634 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 6.92 0.35 2.32e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs11088226 0.681 rs8131384 chr21:33944127 C/T cg09050820 chr6:167586206 TCP10L2 0.72 9.27 0.45 2.38e-18 Gastritis; LUSC trans rs2243480 1.000 rs2243480 chr7:65599196 C/T cg10756647 chr7:56101905 PSPH 0.75 7.66 0.39 2.08e-13 Diabetic kidney disease; LUSC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs34779708 0.931 rs12261654 chr10:35322024 G/A cg03585969 chr10:35415529 CREM 0.61 8.82 0.43 6.24e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4964805 0.954 rs11111785 chr12:104189056 A/G cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC cis rs2637266 1.000 rs2130799 chr10:78322922 C/T cg18941641 chr10:78392320 NA 0.36 6.51 0.34 2.68e-10 Pulmonary function; LUSC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg00990874 chr7:1149470 C7orf50 -0.54 -6.94 -0.36 2.04e-11 Bronchopulmonary dysplasia; LUSC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg26513180 chr16:89883248 FANCA 0.79 6.38 0.33 5.88e-10 Skin colour saturation; LUSC cis rs12367572 0.620 rs1857924 chr12:45344212 T/G cg04608330 chr12:45269318 NELL2 -0.39 -6.01 -0.31 4.98e-9 Gut microbiome composition (summer); LUSC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg05084668 chr3:125655381 ALG1L -0.51 -7.12 -0.36 6.65e-12 Blood pressure (smoking interaction); LUSC cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg01028140 chr2:1542097 TPO -0.6 -8.03 -0.4 1.64e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg22638593 chr5:131593259 PDLIM4 0.41 6.06 0.31 3.6e-9 Breast cancer; LUSC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg17971929 chr21:40555470 PSMG1 -0.67 -11.02 -0.52 2.72e-24 Cognitive function; LUSC cis rs62408225 1.000 rs62408227 chr6:90965171 A/G cg06866423 chr6:90926672 BACH2 0.39 5.68 0.3 2.9e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1577917 1.000 rs1577917 chr6:86691940 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.63 -0.43 2.6e-16 Response to antipsychotic treatment; LUSC cis rs10761482 0.861 rs7089563 chr10:62109898 C/A cg18175470 chr10:62150864 ANK3 -0.5 -7.05 -0.36 1.05e-11 Schizophrenia; LUSC cis rs7584330 0.554 rs1343768 chr2:238444881 G/A cg14458575 chr2:238380390 NA 0.43 5.68 0.3 3e-8 Prostate cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24975666 chr17:80416629 NARF -0.53 -7.03 -0.36 1.2e-11 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg13395646 chr4:1353034 KIAA1530 -0.57 -8.92 -0.44 3.04e-17 Obesity-related traits; LUSC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.45 -7.12 -0.36 6.52e-12 Alzheimer's disease (late onset); LUSC cis rs1371867 0.875 rs1660319 chr8:101337530 A/G cg06636551 chr8:101224915 SPAG1 -0.4 -7.41 -0.38 1.03e-12 Atrioventricular conduction; LUSC cis rs11098499 0.954 rs6834796 chr4:120414693 A/C cg24375607 chr4:120327624 NA 0.79 11.98 0.55 9.22e-28 Corneal astigmatism; LUSC cis rs6845621 0.901 rs1452554 chr4:18920164 A/G cg12196642 chr4:18937545 NA 0.38 7.06 0.36 9.58e-12 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg00945038 chr17:61921165 SMARCD2 0.52 8.73 0.43 1.23e-16 Prudent dietary pattern; LUSC cis rs4478858 0.684 rs10798837 chr1:31719340 C/T cg00250761 chr1:31883323 NA -0.33 -8.03 -0.4 1.71e-14 Alcohol dependence; LUSC cis rs9815354 0.638 rs17284933 chr3:42029835 T/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs4930103 0.590 rs3809101 chr11:1967271 C/T cg06197492 chr11:2016605 H19 0.43 7.37 0.37 1.37e-12 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs561341 0.740 rs11080174 chr17:30208521 C/A cg27661571 chr11:113659931 NA 0.47 5.95 0.31 6.86e-9 Hip circumference adjusted for BMI; LUSC cis rs478304 0.654 rs6591187 chr11:65460086 C/G cg27068330 chr11:65405492 SIPA1 -0.75 -10.33 -0.49 7.02e-22 Acne (severe); LUSC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2839186 0.869 rs17176513 chr21:47682428 A/G cg11766577 chr21:47581405 C21orf56 -0.45 -6.83 -0.35 4.12e-11 Testicular germ cell tumor; LUSC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.45 -0.46 6.09e-19 Electroencephalogram traits; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00092273 chr8:124780287 FAM91A1 -0.52 -6.98 -0.36 1.6e-11 Hepatitis; LUSC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg01097406 chr16:89675127 NA -0.34 -6.7 -0.34 8.66e-11 Vitiligo; LUSC cis rs13385 0.769 rs13163983 chr5:139622572 A/C cg26211634 chr5:139558579 C5orf32 0.46 7.04 0.36 1.09e-11 Atrial fibrillation; LUSC cis rs921968 0.643 rs2556386 chr2:219534530 C/T cg02176678 chr2:219576539 TTLL4 -0.58 -10.42 -0.5 3.44e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs7246657 0.943 rs10424574 chr19:37838393 A/G cg23950597 chr19:37808831 NA -0.64 -7.74 -0.39 1.17e-13 Coronary artery calcification; LUSC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg21724239 chr8:58056113 NA 0.8 8.32 0.41 2.34e-15 Developmental language disorder (linguistic errors); LUSC cis rs911119 0.866 rs4815223 chr20:23577112 C/A cg16589663 chr20:23618590 CST3 0.6 7.1 0.36 7.4e-12 Chronic kidney disease; LUSC cis rs76878669 0.561 rs4930362 chr11:66154360 T/C cg24851651 chr11:66362959 CCS -0.38 -6.08 -0.32 3.34e-9 Educational attainment (years of education); LUSC cis rs4474465 0.688 rs4945300 chr11:78282632 T/C cg27205649 chr11:78285834 NARS2 0.58 7.18 0.37 4.53e-12 Alzheimer's disease (survival time); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19372772 chr2:264904 ACP1;SH3YL1 0.54 7.4 0.38 1.1e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2839186 0.504 rs4347941 chr21:47938239 T/C cg12379764 chr21:47803548 PCNT 0.82 13.35 0.59 7.11e-33 Testicular germ cell tumor; LUSC cis rs10751667 0.666 rs10902243 chr11:949900 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.46 0.33 3.71e-10 Alzheimer's disease (late onset); LUSC cis rs735539 0.521 rs2585895 chr13:21396967 A/T cg04906043 chr13:21280425 IL17D -0.39 -5.68 -0.3 2.89e-8 Dental caries; LUSC trans rs6502050 0.805 rs4356529 chr17:80157797 A/G cg07393940 chr7:158741817 NA -0.37 -6.7 -0.34 8.81e-11 Life satisfaction; LUSC cis rs6598955 0.671 rs17163746 chr1:26564230 C/A cg00852783 chr1:26633632 UBXN11 -0.49 -5.8 -0.3 1.52e-8 Obesity-related traits; LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs35892873 0.703 rs7615776 chr3:126060617 G/A cg15490784 chr3:126061950 KLF15 0.3 5.73 0.3 2.19e-8 Male-pattern baldness; LUSC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg10253484 chr15:75165896 SCAMP2 -0.46 -6.55 -0.34 2.21e-10 Breast cancer; LUSC cis rs10191773 0.522 rs6747639 chr2:112967458 C/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.75 8.15 0.41 7.55e-15 Yeast infection; LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg03354898 chr7:1950403 MAD1L1 -0.35 -6.62 -0.34 1.46e-10 Bipolar disorder and schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03038380 chr15:78591716 WDR61 0.44 6.0 0.31 5.13e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg26335602 chr6:28129616 ZNF389 0.43 5.75 0.3 1.98e-8 Depression; LUSC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg06636001 chr8:8085503 FLJ10661 -0.53 -7.92 -0.4 3.52e-14 Joint mobility (Beighton score); LUSC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.86 0.31 1.13e-8 Tonsillectomy; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg09033563 chr22:24373618 LOC391322 -0.64 -9.7 -0.47 9.08e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9300255 0.679 rs10846507 chr12:123786492 G/T cg13010344 chr12:123464640 ARL6IP4 -0.51 -6.59 -0.34 1.69e-10 Neutrophil percentage of white cells; LUSC cis rs2274273 0.624 rs8003279 chr14:55864130 A/G cg04306507 chr14:55594613 LGALS3 0.46 8.53 0.42 5e-16 Protein biomarker; LUSC cis rs4363385 0.510 rs6677674 chr1:153037601 A/G cg00922841 chr1:152955080 SPRR1A -0.35 -5.9 -0.31 9.08e-9 Inflammatory skin disease; LUSC cis rs1577917 0.958 rs12196230 chr6:86519960 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.22 -0.32 1.48e-9 Response to antipsychotic treatment; LUSC cis rs7177699 0.557 rs8027833 chr15:79112837 T/C cg00540400 chr15:79124168 NA 0.45 8.06 0.4 1.4e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7188861 0.724 rs1794019 chr16:11379775 T/C cg00044050 chr16:11439710 C16orf75 0.59 6.56 0.34 2.01e-10 HDL cholesterol; LUSC cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 13.63 0.6 5.98e-34 Chronic sinus infection; LUSC cis rs1950626 0.716 rs34572720 chr14:101447150 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.76 0.39 1.03e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs4925386 0.808 rs1741634 chr20:60925979 A/C cg24112000 chr20:60950667 NA 0.36 6.82 0.35 4.3e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg09365446 chr1:150670422 GOLPH3L 0.46 7.02 0.36 1.24e-11 Tonsillectomy; LUSC cis rs8060686 0.641 rs12445396 chr16:68155121 G/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.1 -0.32 2.87e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs7100689 0.646 rs10736348 chr10:82139244 C/A cg00277334 chr10:82204260 NA -0.49 -7.06 -0.36 9.93e-12 Post bronchodilator FEV1; LUSC cis rs1564271 1.000 rs1197422 chr10:27012078 A/G cg13837822 chr10:26931731 LOC731789 0.45 8.89 0.44 3.97e-17 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs62400317 0.859 rs62400313 chr6:45256366 A/T cg20913747 chr6:44695427 NA -0.46 -7.45 -0.38 8.27e-13 Total body bone mineral density; LUSC cis rs61931739 0.500 rs56404399 chr12:34543101 A/G cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs9633740 0.842 rs1870140 chr10:82246749 A/G cg01528321 chr10:82214614 TSPAN14 1.07 10.56 0.5 1.1e-22 Post bronchodilator FEV1; LUSC cis rs1908814 0.516 rs11996277 chr8:11800031 G/A cg21775007 chr8:11205619 TDH 0.45 6.34 0.33 7.26e-10 Neuroticism; LUSC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg14004847 chr7:1930337 MAD1L1 -0.56 -8.79 -0.43 8.01e-17 Bipolar disorder and schizophrenia; LUSC cis rs6912958 0.500 rs3828759 chr6:87806640 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.54 -10.34 -0.49 6.22e-22 Monocyte percentage of white cells; LUSC cis rs925255 0.901 rs906805 chr2:28604879 A/G cg01273330 chr2:28605224 NA -0.42 -6.94 -0.36 2e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs41271951 0.512 rs79122717 chr1:151093526 G/A cg11822372 chr1:151115635 SEMA6C -0.78 -7.18 -0.37 4.51e-12 Blood protein levels; LUSC cis rs612683 0.602 rs2030048 chr1:101006577 C/T cg09408571 chr1:101003634 GPR88 -0.3 -5.81 -0.3 1.45e-8 Breast cancer; LUSC trans rs2736345 0.788 rs998683 chr8:11353000 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -6.85 -0.35 3.62e-11 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.49 6.04 0.31 4.1e-9 Renal function-related traits (BUN); LUSC cis rs4474465 1.000 rs10899509 chr11:78170811 C/T cg27205649 chr11:78285834 NARS2 -0.5 -5.87 -0.31 1.04e-8 Alzheimer's disease (survival time); LUSC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg05347473 chr6:146136440 FBXO30 0.54 9.41 0.46 8.08e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.35 0.33 6.88e-10 Menopause (age at onset); LUSC cis rs7267979 0.903 rs6107015 chr20:25216764 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.29 0.67 2.62e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4911259 0.513 rs6057665 chr20:31463460 A/G cg13636640 chr20:31349939 DNMT3B -0.82 -15.9 -0.66 8.57e-43 Inflammatory bowel disease; LUSC cis rs61931739 0.500 rs11053242 chr12:34511625 A/G cg06521331 chr12:34319734 NA -0.41 -6.8 -0.35 4.96e-11 Morning vs. evening chronotype; LUSC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg24209194 chr3:40518798 ZNF619 0.45 6.14 0.32 2.32e-9 Renal cell carcinoma; LUSC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg14582100 chr15:45693742 SPATA5L1 -0.54 -9.42 -0.46 7.85e-19 Homoarginine levels; LUSC cis rs61931739 0.534 rs1586410 chr12:33999142 C/T cg06521331 chr12:34319734 NA -0.46 -7.33 -0.37 1.73e-12 Morning vs. evening chronotype; LUSC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg12257692 chr3:49977190 RBM6 0.24 6.73 0.35 7.19e-11 Intelligence (multi-trait analysis); LUSC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg11764359 chr7:65958608 NA -0.78 -12.55 -0.57 7.46e-30 Aortic root size; LUSC trans rs7819412 0.595 rs4841500 chr8:10988275 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -6.33 -0.33 7.77e-10 Triglycerides; LUSC cis rs701145 0.537 rs357479 chr3:153891489 A/G cg17054900 chr3:154042577 DHX36 0.71 7.3 0.37 2.16e-12 Coronary artery disease; LUSC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs72634258 0.836 rs9658012 chr1:7989022 C/T cg00042356 chr1:8021962 PARK7 0.81 8.95 0.44 2.45e-17 Inflammatory bowel disease; LUSC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg16414030 chr3:133502952 NA -0.42 -6.47 -0.33 3.49e-10 Iron status biomarkers; LUSC trans rs804280 0.509 rs35626932 chr8:11786932 C/A cg06636001 chr8:8085503 FLJ10661 0.55 8.24 0.41 4.03e-15 Myopia (pathological); LUSC cis rs12579753 0.913 rs17749243 chr12:82178079 A/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.13 -0.32 2.47e-9 Resting heart rate; LUSC trans rs11039798 0.588 rs11039855 chr11:48610091 A/G cg03929089 chr4:120376271 NA 0.59 6.44 0.33 4.04e-10 Axial length; LUSC cis rs2760061 0.626 rs596208 chr1:228117982 G/C cg01973587 chr1:228161476 NA 0.45 8.09 0.4 1.15e-14 Diastolic blood pressure; LUSC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.87 -12.64 -0.57 3.45e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg01475377 chr6:109611718 NA -0.44 -8.07 -0.4 1.28e-14 Reticulocyte fraction of red cells; LUSC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg12963246 chr6:28129442 ZNF389 0.43 6.15 0.32 2.26e-9 Depression; LUSC cis rs734999 0.550 rs2985855 chr1:2531372 A/C cg18854424 chr1:2615690 NA -0.49 -9.78 -0.47 5.1e-20 Ulcerative colitis; LUSC cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg02175503 chr12:58329896 NA -0.77 -13.81 -0.6 1.28e-34 Intelligence (multi-trait analysis); LUSC cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg08975724 chr8:8085496 FLJ10661 -0.46 -6.82 -0.35 4.38e-11 Systolic blood pressure; LUSC cis rs6681460 0.800 rs481681 chr1:67194378 G/A cg02459107 chr1:67143332 SGIP1 -0.47 -8.61 -0.43 2.98e-16 Presence of antiphospholipid antibodies; LUSC cis rs12618769 0.543 rs2278211 chr2:99149946 G/A cg10123293 chr2:99228465 UNC50 0.46 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg21573476 chr21:45109991 RRP1B -0.38 -6.07 -0.32 3.48e-9 Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14086791 chr11:69489770 ORAOV1 0.44 5.98 0.31 5.69e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg08847533 chr14:75593920 NEK9 -0.79 -13.55 -0.6 1.2e-33 Height; LUSC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg17985854 chr11:65770987 BANF1;EIF1AD -0.45 -8.27 -0.41 3.14e-15 Eosinophil percentage of white cells; LUSC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg09034736 chr1:150693464 HORMAD1 0.46 6.77 0.35 5.7e-11 Melanoma; LUSC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.63 -5.9 -0.31 8.74e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7520050 0.778 rs3014218 chr1:46026328 A/C cg06784218 chr1:46089804 CCDC17 -0.32 -6.16 -0.32 2.04e-9 Red blood cell count;Reticulocyte count; LUSC cis rs11645898 0.687 rs56129242 chr16:72098260 C/G cg14768367 chr16:72042858 DHODH -0.53 -6.15 -0.32 2.16e-9 Blood protein levels; LUSC cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs7267979 0.932 rs2387891 chr20:25470328 C/G cg03522245 chr20:25566470 NINL 0.36 5.85 0.3 1.17e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.13 -0.45 6.87e-18 Gut microbiome composition (summer); LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg07677032 chr17:61819896 STRADA 0.53 8.93 0.44 2.87e-17 Prudent dietary pattern; LUSC cis rs4595586 0.545 rs12827823 chr12:39392144 G/T cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg18252515 chr7:66147081 NA -0.54 -7.52 -0.38 4.96e-13 Corneal structure; LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 5.01e-10 Systemic lupus erythematosus; LUSC cis rs7215564 0.908 rs2316060 chr17:78663728 T/C cg23238734 chr17:78661607 RPTOR 0.47 6.1 0.32 2.98e-9 Myopia (pathological); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg06370133 chr2:113914844 NA 0.48 6.23 0.32 1.39e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9287719 0.967 rs6759100 chr2:10746710 A/G cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg05855489 chr10:104503620 C10orf26 0.58 9.42 0.46 7.51e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.49e-8 Breast cancer; LUSC cis rs11250098 0.510 rs4840525 chr8:10765635 C/A cg27411982 chr8:10470053 RP1L1 -0.45 -6.71 -0.34 8.52e-11 Morning vs. evening chronotype; LUSC trans rs6952808 0.689 rs79950306 chr7:2022063 C/G cg04565464 chr8:145669602 NFKBIL2 0.4 6.47 0.33 3.41e-10 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs62458065 0.513 rs702831 chr7:32579715 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.96 -0.31 6.41e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg22903657 chr4:1355424 KIAA1530 -0.48 -8.02 -0.4 1.77e-14 Obesity-related traits; LUSC trans rs9650657 0.707 rs2005309 chr8:10652170 T/C cg15556689 chr8:8085844 FLJ10661 -0.42 -6.37 -0.33 6.15e-10 Neuroticism; LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg19539972 chr4:7069911 GRPEL1 -0.74 -9.12 -0.45 7.21e-18 Monocyte percentage of white cells; LUSC cis rs1983170 0.808 rs2219393 chr1:92016577 C/T cg25838465 chr1:92012736 NA 0.43 6.07 0.32 3.41e-9 Eosinophil percentage of white cells; LUSC cis rs11098499 0.530 rs114866537 chr4:120258608 A/T cg09307838 chr4:120376055 NA 0.63 9.65 0.47 1.34e-19 Corneal astigmatism; LUSC cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.36e-22 Alzheimer's disease (late onset); LUSC cis rs8028313 0.630 rs4776373 chr15:67960523 G/A cg08079166 chr15:68083412 MAP2K5 0.35 6.06 0.31 3.73e-9 Obesity; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25733915 chr17:40829168 PLEKHH3 0.47 6.53 0.34 2.47e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6541297 0.941 rs6541294 chr1:230278826 A/G cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.22e-15 Coronary artery disease; LUSC cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg21466736 chr12:48725269 NA -0.33 -5.76 -0.3 1.92e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7607369 0.536 rs6436091 chr2:219669141 T/C cg02176678 chr2:219576539 TTLL4 -0.52 -9.15 -0.45 5.72e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.27 0.45 2.3e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6430585 0.527 rs6753232 chr2:136436317 C/T cg07169764 chr2:136633963 MCM6 -0.96 -11.43 -0.53 9.26e-26 Corneal structure; LUSC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg19748678 chr4:122722346 EXOSC9 0.48 7.49 0.38 6.4e-13 Type 2 diabetes; LUSC cis rs12980942 0.810 rs3745295 chr19:41785282 T/G cg25627403 chr19:41769009 HNRNPUL1 0.59 6.49 0.33 3.13e-10 Coronary artery disease; LUSC cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg05347473 chr6:146136440 FBXO30 -0.45 -7.88 -0.4 4.55e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs62103177 0.789 rs7242289 chr18:77603291 C/T cg14227996 chr4:17616232 MED28 0.75 7.56 0.38 4.01e-13 Opioid sensitivity; LUSC cis rs7107174 1.000 rs2511185 chr11:77982496 C/A cg02023728 chr11:77925099 USP35 0.45 6.83 0.35 4.13e-11 Testicular germ cell tumor; LUSC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.91 -0.31 8.42e-9 Total body bone mineral density; LUSC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -11.92 -0.55 1.5e-27 Mean corpuscular volume; LUSC cis rs6430585 0.528 rs309123 chr2:136761175 C/G cg07169764 chr2:136633963 MCM6 1.13 18.3 0.71 2.67e-52 Corneal structure; LUSC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg22875332 chr1:76189707 ACADM 0.8 11.48 0.53 6.05e-26 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11690935 1.000 rs312925 chr2:172563922 G/A cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.77 -0.63 2.46e-38 Schizophrenia; LUSC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg26727032 chr16:67993705 SLC12A4 -0.44 -5.88 -0.31 9.79e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg26659404 chr1:25747437 RHCE 0.28 5.94 0.31 7.19e-9 Erythrocyte sedimentation rate; LUSC cis rs2404602 0.684 rs1603860 chr15:76849591 A/T cg23625390 chr15:77176239 SCAPER -0.66 -10.08 -0.48 4.7e-21 Blood metabolite levels; LUSC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg26408565 chr15:76604113 ETFA -0.49 -7.87 -0.4 4.85e-14 Blood metabolite levels; LUSC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg21724239 chr8:58056113 NA 0.56 6.86 0.35 3.37e-11 Developmental language disorder (linguistic errors); LUSC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg01368799 chr11:117014884 PAFAH1B2 0.66 10.57 0.5 9.9e-23 Blood protein levels; LUSC cis rs7289126 1.000 rs5995558 chr22:38647639 A/G cg25457927 chr22:38595422 NA -0.29 -5.68 -0.3 2.98e-8 Mammographic density (dense area);Percent mammographic density; LUSC cis rs9513627 1.000 rs2390279 chr13:100208705 A/G cg25919922 chr13:100150906 NA -0.73 -6.26 -0.32 1.17e-9 Obesity-related traits; LUSC trans rs877282 0.898 rs36064821 chr10:760952 C/T cg22713356 chr15:30763199 NA 1.01 13.85 0.6 8.57e-35 Uric acid levels; LUSC trans rs7721647 0.520 rs13355661 chr5:90811629 C/A cg15140562 chr3:48659193 TMEM89 -0.41 -6.03 -0.31 4.24e-9 Breast cancer; LUSC cis rs7804356 1.000 rs73065517 chr7:26830555 T/C cg03456212 chr7:26904342 SKAP2 -0.55 -6.52 -0.34 2.57e-10 Type 1 diabetes; LUSC trans rs6828577 0.560 rs2631147 chr4:119455854 C/T cg26518628 chr1:97050305 NA 0.48 7.21 0.37 3.75e-12 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC cis rs34779708 0.931 rs11010067 chr10:35295431 C/G cg04310649 chr10:35416472 CREM 0.41 6.48 0.33 3.2e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11098499 0.754 rs1980026 chr4:120251643 C/A cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs478304 0.934 rs610037 chr11:65546857 A/C cg08755490 chr11:65554678 OVOL1 0.41 5.91 0.31 8.32e-9 Acne (severe); LUSC cis rs950169 0.887 rs62029593 chr15:84955180 A/G cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.64e-15 Schizophrenia; LUSC cis rs11122272 0.735 rs2749706 chr1:231527170 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs62283056 0.512 rs752854 chr4:6281961 C/T cg00701064 chr4:6280414 WFS1 0.5 10.42 0.5 3.27e-22 Cisplatin-induced ototoxicity; LUSC cis rs4363385 0.553 rs41263664 chr1:152974063 G/A cg25856811 chr1:152973957 SPRR3 -0.36 -6.04 -0.31 4.02e-9 Inflammatory skin disease; LUSC cis rs9467711 0.591 rs13216785 chr6:26079185 C/T cg16898833 chr6:26189333 HIST1H4D 0.64 5.92 0.31 8e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 7.55 0.38 4.17e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9486715 0.867 rs4438964 chr6:96917563 T/G cg06623918 chr6:96969491 KIAA0776 0.94 17.57 0.69 2.06e-49 Headache; LUSC cis rs9393777 0.623 rs9358944 chr6:26469875 A/C cg05738196 chr6:26577821 NA -0.54 -5.81 -0.3 1.48e-8 Intelligence (multi-trait analysis); LUSC cis rs1044826 1.000 rs9289578 chr3:139200514 G/A cg00490450 chr3:139108681 COPB2 0.51 6.79 0.35 5.07e-11 Obesity-related traits; LUSC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg07343612 chr16:622815 PIGQ -0.74 -12.61 -0.57 4.48e-30 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05160915 chr11:111749944 FDXACB1;C11orf1 -0.47 -6.13 -0.32 2.42e-9 Bipolar disorder and schizophrenia; LUSC cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 3.09e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1372520 0.684 rs1837891 chr4:90736131 C/G cg15133208 chr4:90757351 SNCA 0.52 8.02 0.4 1.81e-14 Neuroticism; LUSC cis rs35883536 0.626 rs11799819 chr1:101049382 G/A cg06223162 chr1:101003688 GPR88 -0.47 -8.68 -0.43 1.78e-16 Monocyte count; LUSC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg02038168 chr22:39784481 NA -0.5 -8.21 -0.41 4.96e-15 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.817 rs7798459 chr7:1087965 C/T cg26769984 chr7:1090371 C7orf50 0.7 10.64 0.5 5.85e-23 Bronchopulmonary dysplasia; LUSC cis rs11608355 1.000 rs10850134 chr12:109861454 G/C cg19025524 chr12:109796872 NA -0.38 -5.96 -0.31 6.58e-9 Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17072271 chr17:73400970 GRB2 -0.45 -6.78 -0.35 5.5e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg01097406 chr16:89675127 NA 0.46 9.36 0.46 1.2e-18 Vitiligo; LUSC cis rs1609391 0.561 rs9817967 chr3:136629490 G/A cg15507776 chr3:136538369 TMEM22 0.51 8.36 0.42 1.71e-15 Neuroticism; LUSC cis rs76878669 0.561 rs4630308 chr11:66162587 G/A cg18002602 chr11:66138449 SLC29A2 0.45 7.98 0.4 2.43e-14 Educational attainment (years of education); LUSC cis rs2486288 0.656 rs9920290 chr15:45548035 G/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.01 -0.4 1.89e-14 Glomerular filtration rate; LUSC cis rs4766646 0.542 rs4766635 chr12:110276914 A/G cg10794374 chr12:110278745 NA 0.27 5.85 0.3 1.15e-8 Metabolite levels (MHPG); LUSC cis rs9322193 0.567 rs7747457 chr6:150213502 T/A cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.18e-11 Lung cancer; LUSC trans rs7916697 0.593 rs10762198 chr10:70023053 A/G cg04882175 chr6:131122610 NA 0.46 6.02 0.31 4.47e-9 Optic disc area; LUSC cis rs6882046 0.513 rs2431391 chr5:88046590 C/T cg22951263 chr5:87985283 NA -0.47 -7.72 -0.39 1.39e-13 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg26597838 chr10:835615 NA 0.98 13.76 0.6 1.85e-34 Eosinophil percentage of granulocytes; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg19318889 chr4:1322082 MAEA 0.48 7.83 0.39 6.66e-14 Obesity-related traits; LUSC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg05802129 chr4:122689817 NA -0.5 -8.12 -0.41 9.17e-15 Type 2 diabetes; LUSC cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg21535247 chr6:8435926 SLC35B3 0.59 8.99 0.44 1.88e-17 Motion sickness; LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg08859206 chr1:53392774 SCP2 0.51 8.74 0.43 1.14e-16 Monocyte count; LUSC cis rs9326248 0.520 rs2735183 chr11:117015195 C/T cg20608306 chr11:116969690 SIK3 0.35 6.52 0.34 2.61e-10 Blood protein levels; LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.3e-11 Monocyte count; LUSC cis rs12291225 0.639 rs61883858 chr11:14294708 C/T cg19336497 chr11:14380999 RRAS2 -0.57 -11.78 -0.54 5.12e-27 Sense of smell; LUSC cis rs838147 0.534 rs2638280 chr19:49209318 G/A cg21064579 chr19:49206444 FUT2 0.46 8.65 0.43 2.24e-16 Dietary macronutrient intake; LUSC cis rs2425143 1.000 rs8115150 chr20:34397189 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -5.93 -0.31 7.7e-9 Blood protein levels; LUSC cis rs1878931 0.615 rs6501171 chr16:3402610 T/A cg00484396 chr16:3507460 NAT15 -0.35 -5.82 -0.3 1.36e-8 Body mass index (adult); LUSC cis rs9467773 0.595 rs13207371 chr6:26591074 G/A cg11502198 chr6:26597334 ABT1 0.69 11.3 0.53 2.71e-25 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg23711669 chr6:146136114 FBXO30 -0.82 -14.69 -0.63 5.14e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.71 -0.34 8.54e-11 Lung cancer; LUSC cis rs4953318 1.000 rs4953318 chr2:46355051 A/C cg12428440 chr2:46370979 PRKCE 0.38 6.73 0.35 7.36e-11 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.04 0.31 4.13e-9 Menopause (age at onset); LUSC cis rs7712401 0.601 rs30069 chr5:122293026 A/G cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg09875802 chr5:133340681 VDAC1 0.47 6.27 0.32 1.12e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11190604 1.000 rs10883503 chr10:102275504 C/A cg07080220 chr10:102295463 HIF1AN 0.7 9.42 0.46 7.7e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7264396 0.887 rs224363 chr20:34062710 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -5.89 -0.31 9.54e-9 Total cholesterol levels; LUSC cis rs870825 0.616 rs7658186 chr4:185622509 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.7e-32 Blood protein levels; LUSC cis rs7980687 0.527 rs28533432 chr12:123873242 C/T cg05973401 chr12:123451056 ABCB9 0.5 6.68 0.34 1.02e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs1215050 0.791 rs1025201 chr4:98902938 A/G cg05340658 chr4:99064831 C4orf37 -0.44 -6.91 -0.35 2.44e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1559088 1.000 rs7245404 chr19:33550589 C/T cg27124370 chr19:33622961 WDR88 0.53 6.8 0.35 4.84e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg02569458 chr12:86230093 RASSF9 0.5 8.24 0.41 4.04e-15 Major depressive disorder; LUSC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg18357526 chr6:26021779 HIST1H4A 0.4 6.36 0.33 6.69e-10 Intelligence (multi-trait analysis); LUSC cis rs6597981 0.604 rs7945912 chr11:750849 A/T cg01741372 chr11:783889 NA 0.45 7.99 0.4 2.21e-14 Breast cancer; LUSC cis rs7000551 0.751 rs2443494 chr8:22372262 C/G cg12081754 chr8:22256438 SLC39A14 0.42 6.27 0.32 1.11e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs16974263 1.000 rs16974263 chr19:40913539 A/G cg14150973 chr19:40950431 SERTAD3 -0.7 -7.02 -0.36 1.23e-11 Otitis media;Otitis media (chronic);Otitis media (recurrent); LUSC cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg20891283 chr12:69753455 YEATS4 -0.61 -9.2 -0.45 3.87e-18 Blood protein levels; LUSC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg00631329 chr6:26305371 NA 0.33 5.74 0.3 2.13e-8 Intelligence (multi-trait analysis); LUSC cis rs17102884 0.506 rs11845397 chr14:75404587 G/A cg08847533 chr14:75593920 NEK9 -0.54 -8.08 -0.4 1.23e-14 Neuroticism; LUSC trans rs9914544 0.545 rs8067882 chr17:18807131 A/G cg04702396 chr17:15466718 FAM18B2 0.45 6.95 0.36 1.87e-11 Educational attainment (years of education); LUSC cis rs17253792 0.822 rs10137885 chr14:56173590 A/G cg01858014 chr14:56050164 KTN1 -0.74 -6.34 -0.33 7.62e-10 Putamen volume; LUSC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg13628971 chr7:2884303 GNA12 0.43 6.49 0.33 3.17e-10 Height; LUSC cis rs11166629 1.000 rs6577713 chr8:135645592 C/A cg21672855 chr8:135614777 ZFAT 0.35 5.66 0.3 3.22e-8 Smoking quantity; LUSC cis rs9549260 0.755 rs9566553 chr13:41174231 A/G cg21288729 chr13:41239152 FOXO1 0.58 8.84 0.44 5.5e-17 Red blood cell count; LUSC cis rs8016982 0.963 rs2099108 chr14:81675420 C/G cg01989461 chr14:81687754 GTF2A1 0.57 8.54 0.42 4.86e-16 Schizophrenia; LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg27588902 chr6:42928151 GNMT -0.3 -6.56 -0.34 2.05e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs10504073 0.584 rs74457150 chr8:49890753 C/G cg00325661 chr8:49890786 NA 0.7 10.88 0.51 8.63e-24 Blood metabolite ratios; LUSC cis rs2439831 0.867 rs16957627 chr15:43642657 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.48 -7.68 -0.39 1.73e-13 Alzheimer's disease (late onset); LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg20887711 chr4:1340912 KIAA1530 0.46 7.1 0.36 7.5e-12 Obesity-related traits; LUSC cis rs62458065 0.850 rs62458098 chr7:32471129 G/A cg20159608 chr7:32802032 NA -0.66 -7.83 -0.39 6.35e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9905704 0.647 rs11650809 chr17:56972741 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.41 -0.38 1.02e-12 Testicular germ cell tumor; LUSC cis rs807669 0.903 rs1771540 chr22:19173933 T/A cg02655711 chr22:19163373 SLC25A1 0.91 17.84 0.7 1.74e-50 Metabolite levels; LUSC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12956009 0.583 rs16952069 chr18:44904220 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.38 0.33 6.05e-10 Educational attainment (years of education); LUSC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg00290607 chr11:67383545 NA 0.46 8.79 0.43 7.95e-17 Mean corpuscular volume; LUSC trans rs61931739 0.927 rs12315970 chr12:34038535 A/G cg13010199 chr12:38710504 ALG10B -0.4 -6.04 -0.31 4.04e-9 Morning vs. evening chronotype; LUSC cis rs16910800 0.731 rs59845980 chr11:23191511 T/G cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg07741184 chr6:167504864 NA -0.35 -6.39 -0.33 5.46e-10 Crohn's disease; LUSC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg05890377 chr2:74357713 NA 0.72 13.55 0.6 1.27e-33 Gestational age at birth (maternal effect); LUSC cis rs9790314 1.000 rs336590 chr3:161079583 G/A cg03342759 chr3:160939853 NMD3 -0.5 -8.43 -0.42 1.05e-15 Morning vs. evening chronotype; LUSC cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg09455208 chr3:40491958 NA -0.55 -9.87 -0.48 2.49e-20 Renal cell carcinoma; LUSC cis rs6681460 0.932 rs603750 chr1:67177488 A/G cg02459107 chr1:67143332 SGIP1 0.48 8.96 0.44 2.34e-17 Presence of antiphospholipid antibodies; LUSC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg07636037 chr3:49044803 WDR6 0.96 15.49 0.65 3.57e-41 Parkinson's disease; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg04267008 chr7:1944627 MAD1L1 -0.56 -8.48 -0.42 7.37e-16 Bipolar disorder and schizophrenia; LUSC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.75 -0.8 1.56e-77 Height; LUSC cis rs8008758 0.963 rs10132271 chr14:101688874 C/T cg26224664 chr14:101693935 NA -0.27 -5.7 -0.3 2.61e-8 Body mass index (alcohol intake interaction); LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18301423 chr5:131593218 PDLIM4 0.47 7.46 0.38 7.75e-13 Acylcarnitine levels; LUSC cis rs7824557 0.564 rs34389419 chr8:11229319 C/G cg21775007 chr8:11205619 TDH -0.71 -11.23 -0.52 4.88e-25 Retinal vascular caliber; LUSC cis rs1865760 0.827 rs9295680 chr6:25944103 T/C cg16482183 chr6:26056742 HIST1H1C 0.47 6.94 0.36 2.02e-11 Height; LUSC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg09835421 chr16:68378352 PRMT7 -0.53 -6.01 -0.31 4.86e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg25124228 chr12:125621409 AACS -0.45 -7.37 -0.37 1.37e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15541040 chr2:3486749 NA -0.58 -9.1 -0.45 8.1e-18 Neurofibrillary tangles; LUSC cis rs2798269 0.902 rs12869776 chr13:22103294 A/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.77 -0.3 1.84e-8 PR segment; LUSC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.38 -0.37 1.24e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2070433 0.539 rs56157650 chr21:47957959 T/C cg12379764 chr21:47803548 PCNT 0.79 11.95 0.55 1.2e-27 Lymphocyte counts; LUSC cis rs11153147 0.502 rs75772189 chr6:109416369 C/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.84 -0.3 1.22e-8 Mean corpuscular volume; LUSC cis rs6977660 0.714 rs6945753 chr7:19814255 A/G cg07541023 chr7:19748670 TWISTNB 0.66 7.21 0.37 3.71e-12 Thyroid stimulating hormone; LUSC cis rs6433857 0.657 rs6756509 chr2:181500273 T/C cg23363182 chr2:181467187 NA -0.52 -8.4 -0.42 1.28e-15 Body mass index; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13036321 chr4:166248467 SC4MOL -0.42 -6.31 -0.33 8.78e-10 Electrocardiographic conduction measures; LUSC trans rs561341 1.000 rs542132 chr17:30307193 A/T cg20587970 chr11:113659929 NA -1.25 -17.72 -0.7 5.52e-50 Hip circumference adjusted for BMI; LUSC cis rs1832871 0.655 rs4292552 chr6:158722888 G/A cg07165851 chr6:158734300 TULP4 0.5 7.76 0.39 1.03e-13 Height; LUSC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1008375 0.932 rs11934968 chr4:17667766 A/G cg18681998 chr4:17616180 MED28 0.89 15.31 0.64 1.79e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg09469691 chr10:81107165 PPIF 0.65 9.72 0.47 7.73e-20 Height; LUSC cis rs12545109 0.800 rs1996106 chr8:57412963 A/G cg09654669 chr8:57350985 NA -0.58 -7.84 -0.39 5.98e-14 Obesity-related traits; LUSC cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg14844989 chr11:31128820 NA -0.37 -5.79 -0.3 1.67e-8 Red blood cell count; LUSC cis rs3099143 1.000 rs4886831 chr15:77106801 T/C cg21673338 chr15:77095150 SCAPER 0.78 7.71 0.39 1.43e-13 Recalcitrant atopic dermatitis; LUSC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg21361702 chr7:150065534 REPIN1 0.46 6.29 0.33 1.01e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs1018836 0.884 rs9643307 chr8:91625257 A/C cg16814680 chr8:91681699 NA -0.77 -12.95 -0.58 2.23e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7572644 0.723 rs13019037 chr2:28024642 C/T cg27432699 chr2:27873401 GPN1 0.59 7.6 0.38 2.96e-13 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg16447950 chr5:562315 NA -0.58 -7.3 -0.37 2.1e-12 Obesity-related traits; LUSC cis rs113835537 0.597 rs3737525 chr11:66306355 A/G cg24851651 chr11:66362959 CCS 0.51 7.49 0.38 6.26e-13 Airway imaging phenotypes; LUSC cis rs2797160 0.967 rs80303782 chr6:126004193 C/T cg05901451 chr6:126070800 HEY2 -0.56 -8.15 -0.41 7.47e-15 Endometrial cancer; LUSC cis rs9650657 0.504 rs10109167 chr8:11033525 C/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.25 -0.32 1.24e-9 Neuroticism; LUSC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.6 8.83 0.43 6.15e-17 Total body bone mineral density; LUSC cis rs7582180 0.629 rs12612809 chr2:100951616 G/T cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs6594499 0.872 rs6859041 chr5:110435231 G/A cg04022379 chr5:110408740 TSLP 0.43 6.47 0.33 3.54e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 6.93 0.35 2.14e-11 Platelet count; LUSC cis rs9311676 0.656 rs56384862 chr3:58395863 A/G cg13750441 chr3:58318267 PXK 0.35 6.78 0.35 5.59e-11 Systemic lupus erythematosus; LUSC cis rs6964587 0.839 rs6952459 chr7:91435820 T/A cg22709100 chr7:91322751 NA 0.44 6.44 0.33 4.17e-10 Breast cancer; LUSC cis rs7296418 0.663 rs28450974 chr12:123861420 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.44 -0.33 4.16e-10 Platelet count; LUSC trans rs3857536 0.813 rs1029401 chr6:66952268 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -5.99 -0.31 5.34e-9 Blood trace element (Cu levels); LUSC cis rs11209002 1.000 rs10732838 chr1:67577955 C/T cg02640540 chr1:67518911 SLC35D1 0.69 7.58 0.38 3.42e-13 Crohn's disease; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg25767906 chr1:53392781 SCP2 0.69 13.43 0.59 3.53e-33 Monocyte count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10704137 chr6:25732153 NA 0.52 6.35 0.33 7.1e-10 Bipolar disorder and schizophrenia; LUSC cis rs826838 0.586 rs10785554 chr12:38628749 T/A cg13010199 chr12:38710504 ALG10B 0.49 7.34 0.37 1.65e-12 Heart rate; LUSC cis rs9326248 1.000 rs7107152 chr11:117056080 C/T cg16524733 chr11:117070046 TAGLN -0.41 -7.25 -0.37 2.92e-12 Blood protein levels; LUSC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg09455208 chr3:40491958 NA 0.59 10.13 0.48 3.39e-21 Renal cell carcinoma; LUSC cis rs4631830 0.900 rs9787697 chr10:51533376 C/T cg16070123 chr10:51489643 NA -0.52 -8.25 -0.41 3.65e-15 Prostate-specific antigen levels; LUSC cis rs477692 1.000 rs7475154 chr10:131440584 C/T cg11019008 chr10:131425282 MGMT -0.4 -5.97 -0.31 6.05e-9 Response to temozolomide; LUSC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg00310523 chr12:86230176 RASSF9 -0.41 -7.41 -0.38 1.04e-12 Major depressive disorder; LUSC cis rs929354 0.772 rs6459739 chr7:156998863 A/T cg17757837 chr7:157058334 UBE3C 0.83 13.32 0.59 9.03e-33 Body mass index; LUSC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg01097406 chr16:89675127 NA -0.34 -6.7 -0.34 8.95e-11 Vitiligo; LUSC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg12311346 chr5:56204834 C5orf35 -1.07 -16.62 -0.67 1.31e-45 Initial pursuit acceleration; LUSC cis rs9902453 0.765 rs12601647 chr17:28164953 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.36 0.53 1.62e-25 Coffee consumption (cups per day); LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg07217954 chr7:1067459 C7orf50 0.52 5.67 0.3 3.02e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg05025164 chr4:1340916 KIAA1530 0.66 10.62 0.5 6.68e-23 Longevity; LUSC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg11764359 chr7:65958608 NA -0.82 -13.78 -0.6 1.69e-34 Aortic root size; LUSC cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg12011299 chr4:100065546 ADH4 -0.71 -11.17 -0.52 7.69e-25 Alcohol dependence; LUSC cis rs2109514 0.902 rs717957 chr7:116113107 G/C cg12739419 chr7:116140593 CAV2 -0.27 -5.92 -0.31 7.84e-9 Prevalent atrial fibrillation; LUSC cis rs12540874 0.670 rs3887826 chr7:50544961 G/A cg18232548 chr7:50535776 DDC -0.61 -9.06 -0.44 1.12e-17 Systemic sclerosis; LUSC cis rs9815354 0.812 rs73071338 chr3:41824328 G/A cg03022575 chr3:42003672 ULK4 0.85 8.67 0.43 1.91e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg18681998 chr4:17616180 MED28 0.81 14.6 0.62 1.07e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg23719950 chr11:63933701 MACROD1 -0.59 -7.17 -0.37 4.9e-12 Mean platelet volume; LUSC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg02475777 chr4:1388615 CRIPAK 0.4 5.81 0.3 1.43e-8 Obesity-related traits; LUSC cis rs716595 1.000 rs2050996 chr10:111993697 G/C cg13996003 chr10:112034540 MXI1 -0.7 -5.81 -0.3 1.42e-8 Normalized brain volume; LUSC cis rs763121 0.853 rs8140617 chr22:38970439 A/G cg06022373 chr22:39101656 GTPBP1 -0.79 -11.96 -0.55 1.15e-27 Menopause (age at onset); LUSC cis rs4888262 0.508 rs7189123 chr16:74540097 C/A cg01733217 chr16:74700730 RFWD3 0.74 12.24 0.56 1.05e-28 Testicular germ cell tumor; LUSC cis rs1577917 0.570 rs114854865 chr6:86554236 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs7577851 0.715 rs6708008 chr2:69618072 G/T cg10773587 chr2:69614142 GFPT1 0.58 6.48 0.33 3.24e-10 Parkinson's disease (age of onset); LUSC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg03709012 chr19:19516395 GATAD2A -0.76 -11.85 -0.54 2.77e-27 Tonsillectomy; LUSC cis rs1003719 0.680 rs8130069 chr21:38552116 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.64e-22 Eye color traits; LUSC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg23625390 chr15:77176239 SCAPER 0.53 8.14 0.41 7.77e-15 Blood metabolite levels; LUSC cis rs7980687 0.596 rs1727319 chr12:123701353 T/C cg05973401 chr12:123451056 ABCB9 0.52 7.13 0.36 6.38e-12 Height;Educational attainment;Head circumference (infant); LUSC cis rs17030434 1.000 rs17030434 chr4:154703596 A/G cg14289246 chr4:154710475 SFRP2 -0.53 -7.06 -0.36 9.68e-12 Electrocardiographic conduction measures; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04422289 chr4:48833305 OCIAD1 0.52 6.93 0.35 2.22e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4908769 0.624 rs894875 chr1:8432136 C/T cg00546117 chr1:8445545 RERE 0.3 5.93 0.31 7.58e-9 Allergy; LUSC cis rs11690935 0.851 rs10930502 chr2:172890588 A/G cg13550731 chr2:172543902 DYNC1I2 -0.76 -11.96 -0.55 1.09e-27 Schizophrenia; LUSC cis rs8014204 0.804 rs35769520 chr14:75255115 G/A cg06637938 chr14:75390232 RPS6KL1 0.65 10.68 0.5 4.38e-23 Caffeine consumption; LUSC cis rs1044826 1.000 rs13092507 chr3:139152480 A/G cg00490450 chr3:139108681 COPB2 0.55 7.24 0.37 3.1e-12 Obesity-related traits; LUSC trans rs61931739 0.929 rs10844740 chr12:34067930 C/T cg26384229 chr12:38710491 ALG10B -0.59 -9.51 -0.46 3.95e-19 Morning vs. evening chronotype; LUSC cis rs983392 0.805 rs1834550 chr11:59959843 T/C cg24026212 chr11:59952134 MS4A6A -0.37 -6.26 -0.32 1.21e-9 Alzheimer's disease (late onset); LUSC cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.85 -0.51 1.03e-23 Alzheimer's disease (late onset); LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg07332563 chr6:291687 DUSP22 -0.52 -7.98 -0.4 2.37e-14 Menopause (age at onset); LUSC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg24154853 chr7:158122151 PTPRN2 -0.42 -8.26 -0.41 3.55e-15 Calcium levels; LUSC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg09359103 chr1:154839909 KCNN3 -0.7 -16.3 -0.67 2.36e-44 Prostate cancer; LUSC trans rs61931739 0.746 rs1687003 chr12:34170099 T/A cg13010199 chr12:38710504 ALG10B 0.41 6.48 0.33 3.28e-10 Morning vs. evening chronotype; LUSC cis rs694739 0.726 rs516124 chr11:64128423 G/T cg02228329 chr11:64053129 BAD;GPR137 0.45 6.49 0.33 3.13e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.67 -10.17 -0.49 2.36e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs73198271 0.613 rs11249892 chr8:8657240 C/T cg01851573 chr8:8652454 MFHAS1 0.46 7.45 0.38 8.02e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs2760061 0.603 rs697761 chr1:228192397 G/A cg18477163 chr1:228402036 OBSCN 0.57 9.59 0.46 2.12e-19 Diastolic blood pressure; LUSC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg12365402 chr11:9010492 NRIP3 -0.52 -10.02 -0.48 7.57e-21 Hemoglobin concentration; LUSC cis rs7264396 0.747 rs73283043 chr20:34383863 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.73 -0.43 1.23e-16 Total cholesterol levels; LUSC trans rs2797160 0.904 rs1418637 chr6:125992553 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.66 -0.34 1.12e-10 Endometrial cancer; LUSC cis rs2235642 0.859 rs12599207 chr16:1606445 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.5 0.34 2.95e-10 Coronary artery disease; LUSC trans rs6693295 0.625 rs6680215 chr1:246347153 G/A cg22732515 chr19:44031385 ETHE1 0.44 5.94 0.31 7.06e-9 Migraine - clinic-based;Migraine with aura; LUSC cis rs9815354 0.638 rs73075241 chr3:42058045 C/T cg03022575 chr3:42003672 ULK4 0.78 7.85 0.39 5.64e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg00149659 chr3:10157352 C3orf10 0.89 12.15 0.55 2.18e-28 Alzheimer's disease; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.22 0.56 1.25e-28 Prudent dietary pattern; LUSC cis rs6750047 0.691 rs336032 chr2:38264788 T/C cg07380506 chr2:38303506 CYP1B1 -0.43 -5.92 -0.31 8.2e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg01097406 chr16:89675127 NA 0.48 9.87 0.48 2.53e-20 Vitiligo; LUSC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg01765077 chr12:122356316 WDR66 0.55 7.75 0.39 1.1e-13 Mean corpuscular volume; LUSC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.19e-9 Mean platelet volume; LUSC cis rs7829975 0.560 rs6994131 chr8:8550958 G/A cg06636001 chr8:8085503 FLJ10661 -0.46 -6.46 -0.33 3.67e-10 Mood instability; LUSC cis rs7937682 0.883 rs11213941 chr11:111434094 T/C cg11344533 chr11:111475393 SIK2 0.47 6.34 0.33 7.53e-10 Primary sclerosing cholangitis; LUSC cis rs1670533 1.000 rs2045066 chr4:1052401 C/T cg02018176 chr4:1364513 KIAA1530 0.44 6.49 0.33 3.18e-10 Recombination rate (females); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg08701551 chr17:66287507 ARSG;SLC16A6 -0.45 -6.08 -0.32 3.37e-9 Height; LUSC cis rs7267979 0.744 rs6050463 chr20:25208990 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.68 13.03 0.58 1.18e-31 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.75 -0.8 1.56e-77 Height; LUSC trans rs853679 0.599 rs202906 chr6:28011652 C/T cg06606381 chr12:133084897 FBRSL1 0.62 6.95 0.36 1.91e-11 Depression; LUSC trans rs62238980 0.522 rs118120290 chr22:32399262 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs67460515 0.563 rs68166680 chr3:160829735 T/A cg03342759 chr3:160939853 NMD3 -0.45 -6.23 -0.32 1.41e-9 Parkinson's disease; LUSC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg07424592 chr7:64974309 NA 0.69 6.07 0.32 3.41e-9 Diabetic kidney disease; LUSC cis rs6495367 1.000 rs6495367 chr15:79375347 C/T cg17916960 chr15:79447300 NA 0.34 6.41 0.33 5.01e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg18876405 chr7:65276391 NA 0.68 12.13 0.55 2.6e-28 Aortic root size; LUSC cis rs6456156 0.774 rs1012657 chr6:167525142 A/C cg07741184 chr6:167504864 NA -0.34 -5.9 -0.31 8.82e-9 Primary biliary cholangitis; LUSC cis rs7174348 1 rs7174348 chr15:78792439 G/A cg06917634 chr15:78832804 PSMA4 -0.48 -5.94 -0.31 7.15e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs4604732 0.631 rs74154672 chr1:247625625 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg08975724 chr8:8085496 FLJ10661 0.5 7.47 0.38 7.2e-13 Neuroticism; LUSC cis rs7772486 0.806 rs4075696 chr6:146250947 T/C cg13319975 chr6:146136371 FBXO30 0.47 7.24 0.37 3.19e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg21724239 chr8:58056113 NA 0.81 9.65 0.47 1.4e-19 Developmental language disorder (linguistic errors); LUSC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.77 0.3 1.81e-8 Cerebrospinal P-tau181p levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15649193 chr19:14640403 TECR;MIR639 0.74 6.21 0.32 1.58e-9 Cognitive performance; LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02475777 chr4:1388615 CRIPAK 0.62 9.26 0.45 2.59e-18 Longevity; LUSC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.81 -0.35 4.59e-11 Lung cancer; LUSC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg15839431 chr19:19639596 YJEFN3 -0.42 -5.85 -0.31 1.15e-8 Tonsillectomy; LUSC cis rs6987853 0.787 rs2923437 chr8:42425399 A/C cg09913449 chr8:42400586 C8orf40 0.54 9.56 0.46 2.6e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs7246657 0.882 rs13345148 chr19:37819631 A/G cg23950597 chr19:37808831 NA -0.65 -7.91 -0.4 3.9e-14 Coronary artery calcification; LUSC cis rs2932538 0.922 rs9429694 chr1:113158289 G/A cg22162597 chr1:113214053 CAPZA1 0.69 9.92 0.48 1.67e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs8014204 0.736 rs2111705 chr14:75261641 G/A cg06637938 chr14:75390232 RPS6KL1 0.51 7.9 0.4 3.94e-14 Caffeine consumption; LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.22 0.37 3.5e-12 Platelet count; LUSC cis rs250677 0.524 rs183140 chr5:148438803 G/T cg18129178 chr5:148520854 ABLIM3 -0.57 -9.28 -0.45 2.17e-18 Breast cancer; LUSC cis rs1003719 0.762 rs11701556 chr21:38455153 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.41 0.53 1.1e-25 Eye color traits; LUSC cis rs7100689 0.725 rs10736340 chr10:82061071 C/T cg01528321 chr10:82214614 TSPAN14 0.98 14.61 0.62 1.03e-37 Post bronchodilator FEV1; LUSC cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg25282410 chr6:160211355 TCP1;MRPL18 1.05 16.15 0.66 8.92e-44 Age-related macular degeneration (geographic atrophy); LUSC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg04800585 chr6:26043546 HIST1H2BB 0.38 5.68 0.3 2.89e-8 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11890956 chr21:40555474 PSMG1 -0.87 -15.46 -0.65 4.63e-41 Cognitive function; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.53 7.3 0.37 2.06e-12 Renal function-related traits (BUN); LUSC cis rs7824557 0.510 rs2736297 chr8:11234885 C/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.93 -0.31 7.5e-9 Retinal vascular caliber; LUSC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.71 0.47 8.46e-20 Bipolar disorder; LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg22166914 chr1:53195759 ZYG11B -0.62 -10.29 -0.49 9.65e-22 Monocyte count; LUSC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg26441486 chr22:50317300 CRELD2 -0.54 -8.27 -0.41 3.21e-15 Schizophrenia; LUSC cis rs4499344 0.730 rs417823 chr19:33104561 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.01 0.58 1.39e-31 Mean platelet volume; LUSC cis rs11997175 0.546 rs13282996 chr8:33596397 C/T ch.8.33884649F chr8:33765107 NA 0.48 7.7 0.39 1.54e-13 Body mass index; LUSC cis rs9902453 0.868 rs11080118 chr17:28475379 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.92 -0.44 3.05e-17 Coffee consumption (cups per day); LUSC cis rs9303401 0.659 rs34878689 chr17:56694330 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.06 0.58 8.72e-32 Cognitive test performance; LUSC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg04267008 chr7:1944627 MAD1L1 -0.39 -5.77 -0.3 1.78e-8 Schizophrenia; LUSC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.57 -0.42 3.87e-16 Breast cancer; LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs7605827 0.791 rs7604881 chr2:15476735 T/A cg19274914 chr2:15703543 NA 0.44 8.43 0.42 1.08e-15 Educational attainment (years of education); LUSC cis rs804280 0.509 rs10109241 chr8:11784985 A/T cg21775007 chr8:11205619 TDH 0.47 6.61 0.34 1.54e-10 Myopia (pathological); LUSC cis rs963731 0.522 rs1454222 chr2:39215895 C/A cg04010122 chr2:39346883 SOS1 -0.79 -5.73 -0.3 2.2e-8 Corticobasal degeneration; LUSC cis rs7914558 0.966 rs10748837 chr10:104880236 T/C cg05855489 chr10:104503620 C10orf26 0.6 9.68 0.47 1.1e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs977987 0.931 rs7195161 chr16:75495572 T/C cg04384234 chr16:75411784 CFDP1 -0.48 -7.83 -0.39 6.46e-14 Dupuytren's disease; LUSC cis rs2303282 0.716 rs2966205 chr16:56446612 C/T cg00500540 chr16:56394104 NA -0.44 -7.65 -0.39 2.14e-13 Breast cancer; LUSC cis rs2404602 0.598 rs11634019 chr15:76634680 A/G cg23625390 chr15:77176239 SCAPER -0.55 -7.7 -0.39 1.5700000000000001e-13 Blood metabolite levels; LUSC cis rs478304 0.619 rs10791822 chr11:65428706 T/C cg05805236 chr11:65401703 PCNXL3 -0.63 -10.52 -0.5 1.47e-22 Acne (severe); LUSC cis rs7208859 0.524 rs59913838 chr17:29101563 A/T cg13385521 chr17:29058706 SUZ12P 0.69 6.79 0.35 5.27e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.7 -0.43 1.58e-16 Platelet count; LUSC cis rs6938 0.597 rs4886641 chr15:75228655 C/A cg10253484 chr15:75165896 SCAMP2 -0.46 -6.61 -0.34 1.49e-10 Breast cancer; LUSC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.49e-10 Extrinsic epigenetic age acceleration; LUSC trans rs9393777 0.844 rs28360634 chr6:27332891 T/C cg06606381 chr12:133084897 FBRSL1 -1.0 -9.05 -0.44 1.21e-17 Intelligence (multi-trait analysis); LUSC cis rs9905704 0.624 rs4932691 chr17:57094617 T/C cg12560992 chr17:57184187 TRIM37 -0.64 -10.59 -0.5 9e-23 Testicular germ cell tumor; LUSC cis rs1348850 0.958 rs1545364 chr2:178462882 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.85 0.3 1.16e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12586317 0.620 rs79832710 chr14:35547434 G/T cg16230307 chr14:35515116 FAM177A1 0.81 10.11 0.48 3.77e-21 Psoriasis; LUSC cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg14416269 chr4:6271139 WFS1 0.56 12.24 0.56 1.01e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg20203395 chr5:56204925 C5orf35 -0.5 -7.49 -0.38 6.14e-13 Coronary artery disease; LUSC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg22875332 chr1:76189707 ACADM -0.71 -10.0 -0.48 9.07e-21 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs2679649 1.000 rs2679646 chr6:122352143 A/G cg00167820 chr8:131663355 NA 0.55 6.42 0.33 4.79e-10 Subcutaneous adipose tissue; LUSC cis rs6005807 0.640 rs2013784 chr22:28923933 C/T cg12565055 chr22:29076175 TTC28 -0.53 -5.76 -0.3 1.93e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg12751644 chr20:60527061 NA -0.35 -6.2 -0.32 1.69e-9 Body mass index; LUSC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg04414720 chr1:150670196 GOLPH3L -0.53 -8.35 -0.42 1.87e-15 Melanoma; LUSC trans rs17641971 0.899 rs818557 chr8:49984515 G/C cg15678142 chr1:167411538 CD247 0.4 6.0 0.31 5.08e-9 Blood metabolite levels; LUSC cis rs763121 0.962 rs1980455 chr22:38925719 A/C cg06022373 chr22:39101656 GTPBP1 0.76 12.31 0.56 5.79e-29 Menopause (age at onset); LUSC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg15664640 chr17:80829946 TBCD 0.53 9.33 0.45 1.56e-18 Breast cancer; LUSC cis rs6960043 0.818 rs10950550 chr7:15063923 T/G cg19272540 chr7:15055459 NA 0.33 8.01 0.4 1.91e-14 Type 2 diabetes; LUSC cis rs238295 0.805 rs1983694 chr20:5574134 T/C cg15842884 chr20:5591925 RP5-1022P6.2 -0.44 -5.95 -0.31 6.87e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs1003719 0.751 rs55740803 chr21:38542761 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg17173187 chr15:85201210 NMB 0.37 6.56 0.34 2.08e-10 Schizophrenia; LUSC cis rs3812762 0.871 rs10734637 chr11:8788225 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.37 6.36 0.33 6.54e-10 Hypospadias; LUSC trans rs17495987 1.000 rs17495987 chr7:7899965 A/G cg25844211 chr1:229761456 URB2;TAF5L 0.46 5.98 0.31 5.7e-9 Tonsillectomy; LUSC cis rs9341808 0.718 rs2179842 chr6:80979053 T/C cg08355045 chr6:80787529 NA 0.56 9.78 0.47 4.95e-20 Sitting height ratio; LUSC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC trans rs2228479 0.850 rs11645916 chr16:89835234 G/A cg24644049 chr4:85504048 CDS1 0.87 7.49 0.38 6.2e-13 Skin colour saturation; LUSC cis rs877282 1.000 rs7100358 chr10:773681 G/A cg17470449 chr10:769945 NA 0.49 6.88 0.35 2.93e-11 Uric acid levels; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.07e-17 Prudent dietary pattern; LUSC cis rs6665290 0.835 rs11578479 chr1:227210888 A/T cg10327440 chr1:227177885 CDC42BPA -1.23 -39.49 -0.91 6.94e-128 Myeloid white cell count; LUSC cis rs11676348 0.805 rs12694428 chr2:218958820 G/A cg00012203 chr2:219082015 ARPC2 -0.52 -7.96 -0.4 2.7e-14 Ulcerative colitis; LUSC cis rs8044868 0.586 rs2070937 chr16:72089740 A/G cg16579770 chr16:72058938 DHODH 0.34 5.73 0.3 2.24e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs2295359 0.892 rs11209004 chr1:67613932 G/A cg12940439 chr1:67600707 NA 0.37 6.11 0.32 2.71e-9 Psoriasis; LUSC trans rs2727405 1.000 rs2727405 chr11:13090942 G/A cg19779488 chr5:171679572 UBTD2 0.42 6.05 0.31 3.82e-9 Obesity-related traits; LUSC cis rs2932538 0.922 rs7522110 chr1:113072914 A/C cg22162597 chr1:113214053 CAPZA1 0.72 10.22 0.49 1.58e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs9303401 0.646 rs9892425 chr17:57241938 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.47 7.02 0.36 1.23e-11 Cognitive test performance; LUSC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC trans rs11992162 0.560 rs13256329 chr8:11782214 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.41 -0.33 5.05e-10 Monocyte count; LUSC cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg05347473 chr6:146136440 FBXO30 -0.48 -8.1 -0.41 1.01e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg06151567 chr1:17765735 RCC2 0.39 6.01 0.31 4.82e-9 Schizophrenia; LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg20295408 chr7:1910781 MAD1L1 -0.41 -5.78 -0.3 1.71e-8 Bipolar disorder and schizophrenia; LUSC cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg23583168 chr7:148888333 NA -0.9 -16.96 -0.68 5.43e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7246967 0.673 rs12985495 chr19:22930378 A/G cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg04511125 chr2:88470314 THNSL2 0.64 5.87 0.31 1.07e-8 Plasma clusterin levels; LUSC cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg05347473 chr6:146136440 FBXO30 0.57 9.83 0.47 3.39e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg00132208 chr4:10120780 NA 0.35 5.71 0.3 2.49e-8 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7107174 1.000 rs11237456 chr11:78040780 C/G cg02023728 chr11:77925099 USP35 0.45 6.83 0.35 4.06e-11 Testicular germ cell tumor; LUSC cis rs9325144 0.560 rs10785562 chr12:38637419 A/C cg26384229 chr12:38710491 ALG10B -0.67 -10.32 -0.49 7.33e-22 Morning vs. evening chronotype; LUSC cis rs2717559 0.542 rs34147336 chr8:143884869 A/G cg17252645 chr8:143867129 LY6D -0.55 -10.55 -0.5 1.2e-22 Urinary tract infection frequency; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg16405210 chr4:1374714 KIAA1530 -0.82 -14.19 -0.61 4.12e-36 Longevity; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -8.57 -0.42 3.92e-16 Lymphocyte counts; LUSC cis rs2067615 0.599 rs10778508 chr12:107159405 A/G cg19260189 chr12:106995001 RFX4 -0.22 -5.69 -0.3 2.83e-8 Heart rate; LUSC cis rs7172677 1.000 rs8032261 chr15:75424012 A/T cg14664628 chr15:75095509 CSK -0.44 -5.8 -0.3 1.55e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6733011 0.578 rs10181972 chr2:99497284 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.87 -0.35 3.14e-11 Bipolar disorder; LUSC cis rs2204008 0.569 rs11495449 chr12:37995753 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.86 0.51 9.62e-24 Bladder cancer; LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg11494091 chr17:61959527 GH2 0.65 13.73 0.6 2.61e-34 Prudent dietary pattern; LUSC trans rs61931739 0.500 rs34167298 chr12:34534338 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg06060754 chr5:176797920 RGS14 0.56 8.96 0.44 2.38e-17 Hemoglobin concentration;Hematocrit; LUSC cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC trans rs561341 0.714 rs474455 chr17:30312465 A/T cg20587970 chr11:113659929 NA -1.12 -15.55 -0.65 2.16e-41 Hip circumference adjusted for BMI; LUSC cis rs225245 0.817 rs225302 chr17:33922396 C/T cg05299278 chr17:33885742 SLFN14 0.31 6.93 0.35 2.22e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs17270561 0.578 rs76182885 chr6:25904085 G/C cg17691542 chr6:26056736 HIST1H1C 0.98 12.62 0.57 3.96e-30 Iron status biomarkers; LUSC cis rs3857536 0.813 rs6455083 chr6:66935406 T/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs2637266 1.000 rs12251862 chr10:78367929 A/G cg18941641 chr10:78392320 NA 0.4 7.35 0.37 1.54e-12 Pulmonary function; LUSC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg06740227 chr12:86229804 RASSF9 -0.36 -5.7 -0.3 2.61e-8 Major depressive disorder; LUSC trans rs2243480 1.000 rs56985706 chr7:65394562 C/T cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg05084668 chr3:125655381 ALG1L -0.49 -6.98 -0.36 1.64e-11 Blood pressure (smoking interaction); LUSC cis rs61990749 0.597 rs1978416 chr14:78227901 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.57 0.34 1.94e-10 Fibroblast growth factor basic levels; LUSC cis rs6982240 0.514 rs1865247 chr8:142274654 A/T cg27411547 chr8:142287226 NA -0.48 -8.13 -0.41 8.27e-15 Tonsillectomy; LUSC cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.46 0.5 2.53e-22 Schizophrenia; LUSC cis rs9811920 0.928 rs9865713 chr3:99870299 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.33 6.2 0.32 1.64e-9 Axial length; LUSC cis rs7954584 0.635 rs7137218 chr12:122342877 G/T cg10207240 chr12:122356781 WDR66 0.45 6.55 0.34 2.2e-10 Mean corpuscular volume; LUSC cis rs1372520 0.684 rs2583978 chr4:90750326 A/C cg01966878 chr4:90757139 SNCA -0.42 -5.96 -0.31 6.24e-9 Neuroticism; LUSC cis rs4663866 1.000 rs71426509 chr2:239175334 A/C cg16914508 chr2:239161102 PER2 0.68 7.15 0.36 5.4e-12 Irritable bowel syndrome; LUSC cis rs7267979 0.789 rs6083841 chr20:25384564 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.76 -15.27 -0.64 2.7e-40 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10743315 0.557 rs17505123 chr12:19301353 G/A cg02471346 chr12:19282374 PLEKHA5 0.86 6.8 0.35 4.76e-11 Gut microbiota (bacterial taxa); LUSC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg00310523 chr12:86230176 RASSF9 -0.51 -9.9 -0.48 1.91e-20 Major depressive disorder; LUSC cis rs12681288 0.676 rs7459467 chr8:999359 C/T cg15309053 chr8:964076 NA 0.41 8.29 0.41 2.81e-15 Schizophrenia; LUSC cis rs1559088 0.847 rs2287680 chr19:33608566 A/G cg17764715 chr19:33622953 WDR88 -0.58 -8.07 -0.4 1.32e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs724744 0.680 rs1318602 chr6:22357342 A/G cg13807341 chr11:118445984 ARCN1 -0.35 -5.94 -0.31 6.98e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs12291225 0.679 rs11605531 chr11:14291594 A/G cg05501817 chr11:14380813 RRAS2 -0.59 -9.36 -0.46 1.22e-18 Sense of smell; LUSC cis rs11098499 0.710 rs6851130 chr4:120133712 G/A cg09307838 chr4:120376055 NA -0.6 -8.89 -0.44 3.85e-17 Corneal astigmatism; LUSC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg04455712 chr21:45112962 RRP1B 0.48 8.89 0.44 3.85e-17 Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21800906 chr11:32914818 QSER1 0.44 6.21 0.32 1.55e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg08975724 chr8:8085496 FLJ10661 0.53 7.91 0.4 3.89e-14 Mood instability; LUSC cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg13319975 chr6:146136371 FBXO30 0.49 7.42 0.38 9.85e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs8170 0.603 rs971693 chr19:17422649 G/C cg04749549 chr19:17459798 NA -0.31 -5.76 -0.3 1.94e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC cis rs2286503 0.839 rs2270105 chr7:22862467 G/A cg11367502 chr7:22862612 TOMM7 0.46 6.26 0.32 1.17e-9 Fibrinogen; LUSC cis rs11997175 0.624 rs17701219 chr8:33728795 T/A ch.8.33884649F chr8:33765107 NA 0.49 7.32 0.37 1.89e-12 Body mass index; LUSC cis rs57920188 0.535 rs4295856 chr1:4094842 C/T cg20703997 chr1:4087676 NA 0.55 7.76 0.39 1.04e-13 Interleukin-17 levels; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg11266682 chr4:10021025 SLC2A9 -0.5 -8.52 -0.42 5.5e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs539096 0.540 rs37452 chr1:44297573 A/C cg15962314 chr1:44399869 ARTN 0.24 5.86 0.31 1.12e-8 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -7.37 -0.37 1.33e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11971779 0.680 rs28579232 chr7:139073116 C/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs710216 0.957 rs3738514 chr1:43426591 A/G cg03128534 chr1:43423976 SLC2A1 -0.49 -6.56 -0.34 2.03e-10 Red cell distribution width; LUSC cis rs6500602 0.893 rs6500596 chr16:4470027 G/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.08 0.36 8.52e-12 Schizophrenia; LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg22663859 chr13:21900854 NA 0.29 5.69 0.3 2.78e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs10193935 0.901 rs10201586 chr2:42622594 C/G cg27598129 chr2:42591480 NA -0.61 -8.21 -0.41 4.98e-15 Colonoscopy-negative controls vs population controls; LUSC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg15704280 chr7:45808275 SEPT13 -0.51 -7.18 -0.37 4.51e-12 HDL cholesterol; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg18110333 chr6:292329 DUSP22 -0.73 -12.1 -0.55 3.44e-28 Menopause (age at onset); LUSC trans rs6600671 0.967 rs12069545 chr1:121172203 A/G cg08727972 chr1:148025634 NBPF14 0.45 6.25 0.32 1.24e-9 Hip geometry; LUSC cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg17063962 chr7:91808500 NA 0.56 8.55 0.42 4.54e-16 Breast cancer; LUSC trans rs6601327 0.571 rs7838571 chr8:9647796 A/G cg15556689 chr8:8085844 FLJ10661 0.48 7.1 0.36 7.66e-12 Multiple myeloma (hyperdiploidy); LUSC cis rs8060686 0.545 rs74629553 chr16:68176415 C/A cg09835421 chr16:68378352 PRMT7 -0.59 -6.21 -0.32 1.55e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7589342 0.536 rs17201484 chr2:106394809 C/G cg14210321 chr2:106509881 NCK2 -0.4 -5.72 -0.3 2.33e-8 Addiction; LUSC cis rs7617773 0.817 rs11130163 chr3:48312658 T/C cg20734569 chr3:48348370 SPINK8 -0.44 -7.69 -0.39 1.68e-13 Coronary artery disease; LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg11062466 chr8:58055876 NA 0.75 9.1 0.45 8.12e-18 Developmental language disorder (linguistic errors); LUSC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg15790184 chr11:494944 RNH1 0.49 7.53 0.38 4.71e-13 Systemic lupus erythematosus; LUSC cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg01448562 chr3:133502909 NA 0.59 9.31 0.45 1.79e-18 Alcohol consumption (transferrin glycosylation); LUSC cis rs7903847 0.642 rs7078782 chr10:99168604 C/T cg08345082 chr10:99160200 RRP12 -0.35 -7.27 -0.37 2.51e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.74 -0.39 1.21e-13 Chronic sinus infection; LUSC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs4730250 0.640 rs7783562 chr7:106917438 G/T cg02696742 chr7:106810147 HBP1 -0.49 -5.89 -0.31 9.32e-9 Osteoarthritis; LUSC cis rs11190604 1.000 rs7084810 chr10:102297546 A/G cg23241863 chr10:102295624 HIF1AN 0.48 5.91 0.31 8.26e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4319547 0.585 rs10846792 chr12:122882374 T/C cg23029597 chr12:123009494 RSRC2 -0.75 -9.52 -0.46 3.6e-19 Body mass index; LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.39 0.67 1.04e-44 Platelet count; LUSC trans rs28588043 0.550 rs61816051 chr1:170953276 T/C cg07135042 chr19:56905152 ZNF582 -0.62 -6.3 -0.33 9.37e-10 Number of children (6+ vs. 0 or 1); LUSC cis rs727505 0.954 rs2239532 chr7:124405676 A/C cg23710748 chr7:124431027 NA -0.42 -7.54 -0.38 4.44e-13 Lewy body disease; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg08677398 chr8:58056175 NA 0.51 6.68 0.34 9.95e-11 Developmental language disorder (linguistic errors); LUSC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg17994390 chr8:95565953 KIAA1429 0.46 6.31 0.33 8.86e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs9356171 0.572 rs13198847 chr6:164326504 T/C cg25752492 chr6:164341247 NA -0.38 -6.6 -0.34 1.64e-10 Diisocyanate-induced asthma; LUSC cis rs1419980 0.586 rs10845548 chr12:7777657 T/A cg25828445 chr12:7781288 NA -0.62 -6.49 -0.33 3.04e-10 HDL cholesterol levels; LUSC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg11494091 chr17:61959527 GH2 0.38 6.57 0.34 1.96e-10 Height; LUSC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg12463550 chr7:65579703 CRCP -0.52 -7.55 -0.38 4.17e-13 Aortic root size; LUSC cis rs12421382 0.659 rs57978015 chr11:109385473 T/C cg27471124 chr11:109292789 C11orf87 0.43 7.61 0.38 2.86e-13 Schizophrenia; LUSC cis rs612683 0.664 rs6702766 chr1:100997635 A/G cg09408571 chr1:101003634 GPR88 -0.31 -5.75 -0.3 2.01e-8 Breast cancer; LUSC cis rs6977660 0.714 rs17141945 chr7:19805056 T/A cg07541023 chr7:19748670 TWISTNB 0.64 6.92 0.35 2.28e-11 Thyroid stimulating hormone; LUSC cis rs1348850 0.651 rs4893931 chr2:178228212 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 6.36 0.33 6.75e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs965513 0.901 rs1877431 chr9:100534147 C/T cg13688889 chr9:100608707 NA 0.4 5.91 0.31 8.66e-9 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC trans rs8002861 0.935 rs4101376 chr13:44469835 C/T cg12856521 chr11:46389249 DGKZ -0.38 -6.0 -0.31 5.21e-9 Leprosy; LUSC cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.5e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2274273 0.624 rs78205412 chr14:55781250 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.7 0.47 9.23e-20 Protein biomarker; LUSC trans rs11098499 0.954 rs17005535 chr4:120411562 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.55 0.34 2.18e-10 Corneal astigmatism; LUSC cis rs1997103 1.000 rs10252413 chr7:55396740 C/G cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.52e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg02951883 chr7:2050386 MAD1L1 -0.58 -10.69 -0.51 3.79e-23 Bipolar disorder and schizophrenia; LUSC cis rs9314323 0.692 rs6557914 chr8:26208744 G/C cg13160058 chr8:26243215 BNIP3L -0.4 -7.02 -0.36 1.26e-11 Red cell distribution width; LUSC cis rs9443189 0.570 rs775072 chr6:76377998 G/A cg01950844 chr6:76311363 SENP6 -0.68 -6.84 -0.35 3.85e-11 Prostate cancer; LUSC cis rs10740039 0.516 rs2393646 chr10:62319434 G/A cg18175470 chr10:62150864 ANK3 -0.45 -6.89 -0.35 2.87e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4253772 0.720 rs4253778 chr22:46630634 C/G cg24881330 chr22:46731750 TRMU 0.65 7.96 0.4 2.75e-14 LDL cholesterol;Cholesterol, total; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg26338869 chr17:61819248 STRADA 0.4 5.73 0.3 2.21e-8 Prudent dietary pattern; LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg13395646 chr4:1353034 KIAA1530 0.62 9.93 0.48 1.53e-20 Obesity-related traits; LUSC cis rs7296418 0.699 rs11057254 chr12:123794581 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.49 -0.33 3.11e-10 Platelet count; LUSC cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg06552810 chr11:31128660 NA -0.4 -7.16 -0.36 5.12e-12 Red blood cell count; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg13732083 chr21:47605072 C21orf56 0.47 6.91 0.35 2.48e-11 Testicular germ cell tumor; LUSC cis rs2795502 0.630 rs4948698 chr10:43539459 A/G cg08461752 chr10:43522343 NA 0.57 7.34 0.37 1.64e-12 Blood protein levels; LUSC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.17e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg09365446 chr1:150670422 GOLPH3L 0.51 7.5 0.38 5.68e-13 Melanoma; LUSC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.2 -0.72 6.74e-56 Height; LUSC cis rs7584330 0.704 rs7602387 chr2:238356795 A/G cg14458575 chr2:238380390 NA 0.68 12.24 0.56 1.06e-28 Prostate cancer; LUSC cis rs7264396 1.000 rs6060479 chr20:34165723 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.5 7.35 0.37 1.54e-12 Total cholesterol levels; LUSC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs11122272 0.735 rs2474631 chr1:231541341 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.22 -0.49 1.65e-21 Hemoglobin concentration; LUSC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg06850241 chr22:41845214 NA -0.3 -5.73 -0.3 2.26e-8 Vitiligo; LUSC cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg16339924 chr4:17578868 LAP3 0.6 9.05 0.44 1.23e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs11250097 0.549 rs11778177 chr8:11310362 C/T cg15556689 chr8:8085844 FLJ10661 -0.59 -8.22 -0.41 4.66e-15 Neuroticism; LUSC cis rs6964587 1.000 rs6979085 chr7:91673623 C/T cg17063962 chr7:91808500 NA 0.58 9.29 0.45 2.01e-18 Breast cancer; LUSC cis rs17253792 0.822 rs11546 chr14:56146357 G/A cg01858014 chr14:56050164 KTN1 -0.82 -7.11 -0.36 7.29e-12 Putamen volume; LUSC cis rs11190604 1.000 rs4919471 chr10:102299239 A/G cg16342193 chr10:102329863 NA -0.36 -6.6 -0.34 1.6e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3806843 0.517 rs246031 chr5:140333107 G/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.81 -0.43 6.92e-17 Bipolar disorder; LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4631830 0.720 rs12763717 chr10:51500874 C/G cg20129853 chr10:51489980 NA 0.37 7.54 0.38 4.58e-13 Prostate-specific antigen levels; LUSC trans rs4332037 0.586 rs62442944 chr7:2015047 T/G cg11693508 chr17:37793320 STARD3 0.56 6.81 0.35 4.6e-11 Bipolar disorder; LUSC trans rs10411161 0.657 rs67462252 chr19:52382851 T/C cg22319618 chr22:45562946 NUP50 -0.5 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg24675056 chr1:15929824 NA 0.46 7.91 0.4 3.85e-14 Systolic blood pressure; LUSC trans rs1493916 1.000 rs4799729 chr18:31393521 C/T cg13755796 chr4:20253514 NA 0.44 6.54 0.34 2.34e-10 Life satisfaction; LUSC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg09835421 chr16:68378352 PRMT7 -0.54 -6.08 -0.32 3.32e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs5756813 0.688 rs56114444 chr22:38123364 C/T cg19894588 chr14:64061835 NA -0.52 -6.75 -0.35 6.5500000000000006e-11 Optic cup area;Vertical cup-disc ratio; LUSC cis rs6456156 0.586 rs7761977 chr6:167485678 A/G cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs11971779 0.680 rs7805824 chr7:139111169 C/G cg07862535 chr7:139043722 LUC7L2 -0.57 -7.22 -0.37 3.54e-12 Diisocyanate-induced asthma; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg22946670 chr1:154909930 PMVK 0.35 5.96 0.31 6.54e-9 Triglycerides; LUSC cis rs41271951 0.512 rs11204774 chr1:151062957 C/T cg11822372 chr1:151115635 SEMA6C -0.75 -7.2 -0.37 4.11e-12 Blood protein levels; LUSC cis rs11603020 0.950 rs28362950 chr11:57371918 G/A cg23127183 chr11:57508653 C11orf31 -0.47 -6.44 -0.33 4.23e-10 Blood protein levels; LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.6 0.54 2.24e-26 Menopause (age at onset); LUSC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC trans rs2243480 0.831 rs7806717 chr7:65393174 A/G cg10756647 chr7:56101905 PSPH -0.87 -8.55 -0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs11098499 0.644 rs17517414 chr4:120262101 G/C cg24375607 chr4:120327624 NA 0.7 11.27 0.52 3.51e-25 Corneal astigmatism; LUSC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg16989086 chr20:62203971 PRIC285 0.43 5.96 0.31 6.48e-9 Glioblastoma; LUSC cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg08999081 chr20:33150536 PIGU 0.37 6.82 0.35 4.34e-11 Height; LUSC cis rs6960043 0.818 rs10267273 chr7:15053589 A/G cg19272540 chr7:15055459 NA -0.34 -8.37 -0.42 1.63e-15 Type 2 diabetes; LUSC cis rs1577917 0.629 rs6927475 chr6:86206773 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 6.91 0.35 2.46e-11 Response to antipsychotic treatment; LUSC cis rs796364 0.806 rs10445791 chr2:201078307 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -8.05 -0.4 1.51e-14 Schizophrenia; LUSC cis rs7940866 0.804 rs6590540 chr11:130805444 T/C cg12179176 chr11:130786555 SNX19 0.64 9.66 0.47 1.28e-19 Schizophrenia; LUSC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg26677194 chr12:130822605 PIWIL1 0.59 8.77 0.43 9.52e-17 Menopause (age at onset); LUSC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs7927592 0.871 rs17603185 chr11:68376241 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.76 -0.3 1.92e-8 Total body bone mineral density; LUSC cis rs367943 0.712 rs1850407 chr5:112721569 C/A cg12552261 chr5:112820674 MCC 0.37 6.12 0.32 2.69e-9 Type 2 diabetes; LUSC cis rs5758659 1.000 rs134869 chr22:42652074 G/A cg05082376 chr22:42548792 NA -0.4 -6.66 -0.34 1.16e-10 Cognitive function; LUSC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg22467129 chr15:76604101 ETFA -0.42 -6.64 -0.34 1.28e-10 Blood metabolite levels; LUSC trans rs11681884 0.786 rs11897709 chr2:113809290 G/A cg19632953 chr13:113635898 MCF2L 0.69 6.03 0.31 4.45e-9 Stroke; LUSC cis rs11608355 0.705 rs6663 chr12:109886603 G/A cg05360138 chr12:110035743 NA 0.56 6.97 0.36 1.73e-11 Neuroticism; LUSC cis rs3740393 0.562 rs60459635 chr10:104500988 T/G cg05855489 chr10:104503620 C10orf26 0.56 5.74 0.3 2.07e-8 Microalbuminuria; LUSC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg15448220 chr1:150897856 SETDB1 0.43 6.33 0.33 8.02e-10 Melanoma; LUSC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg22029157 chr1:209979665 IRF6 0.71 8.47 0.42 7.71e-16 Coronary artery disease; LUSC cis rs11098499 0.863 rs17050695 chr4:120489527 G/T cg24375607 chr4:120327624 NA 0.65 10.63 0.5 6.26e-23 Corneal astigmatism; LUSC cis rs9527 0.590 rs7067663 chr10:104883650 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC trans rs7647973 0.710 rs1491983 chr3:49639803 G/T cg21659725 chr3:3221576 CRBN -0.72 -8.2 -0.41 5.17e-15 Menarche (age at onset); LUSC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.48 7.83 0.39 6.52e-14 Vitiligo; LUSC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.48 6.03 0.31 4.34e-9 Multiple sclerosis; LUSC cis rs67072384 1.000 rs2365441 chr11:72450226 T/C cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.4e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.47e-8 Breast cancer; LUSC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg24829409 chr8:58192753 C8orf71 0.52 5.98 0.31 5.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504073 0.584 rs1511368 chr8:49949523 A/T cg00325661 chr8:49890786 NA 0.69 11.04 0.52 2.2e-24 Blood metabolite ratios; LUSC trans rs12210905 0.622 rs116198502 chr6:26915015 A/G cg11837749 chr1:55047332 ACOT11 0.55 5.97 0.31 6.14e-9 Hip circumference adjusted for BMI; LUSC cis rs6598955 0.671 rs12086573 chr1:26574330 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.63 -10.19 -0.49 2.09e-21 Cognitive test performance; LUSC cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg13736514 chr6:26305472 NA -0.45 -8.91 -0.44 3.34e-17 Educational attainment; LUSC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg03452623 chr4:187889614 NA -0.88 -18.2 -0.71 6.32e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg18538332 chr22:24372958 LOC391322 -0.48 -8.65 -0.43 2.14e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs3960554 0.808 rs57721466 chr7:75710049 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 9.49 0.46 4.38e-19 Eotaxin levels; LUSC cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg21770322 chr7:97807741 LMTK2 -0.49 -7.95 -0.4 2.97e-14 Breast cancer; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg09361219 chr2:61293079 KIAA1841 0.39 6.15 0.32 2.16e-9 Metabolite levels (Pyroglutamine); LUSC cis rs7408868 0.764 rs62113791 chr19:15277009 C/T cg14696996 chr19:15285081 NOTCH3 0.99 9.07 0.44 1.06e-17 Pulse pressure; LUSC cis rs72634258 0.945 rs7522911 chr1:8097145 C/T cg00042356 chr1:8021962 PARK7 0.84 10.05 0.48 5.98e-21 Inflammatory bowel disease; LUSC cis rs1559088 0.948 rs7257858 chr19:33591231 T/C cg03563238 chr19:33554763 RHPN2 -0.4 -6.47 -0.33 3.46e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs478304 0.651 rs10896037 chr11:65503424 A/G cg10604040 chr11:65559109 OVOL1 0.31 5.75 0.3 1.99e-8 Acne (severe); LUSC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg07661805 chr8:143867942 LY6D -0.25 -5.93 -0.31 7.69e-9 Urinary tract infection frequency; LUSC cis rs3806843 1.000 rs7710794 chr5:140209467 T/G cg26395211 chr5:140044315 WDR55 -0.37 -5.7 -0.3 2.69e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs4319547 0.688 rs6489158 chr12:123110365 T/G cg05707623 chr12:122985044 ZCCHC8 -0.52 -7.42 -0.38 9.66e-13 Body mass index; LUSC cis rs1577917 0.771 rs2783171 chr6:86382765 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.69 10.94 0.51 5.25e-24 Response to antipsychotic treatment; LUSC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -8.97 -0.44 2.1e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -6.55 -0.34 2.24e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7100689 0.784 rs4934153 chr10:82191255 T/C cg01528321 chr10:82214614 TSPAN14 1.16 19.38 0.73 1.38e-56 Post bronchodilator FEV1; LUSC cis rs10108704 1.000 rs28463252 chr8:110360137 T/A cg20147595 chr8:110349212 ENY2 -0.44 -5.75 -0.3 2.04e-8 Multiple system atrophy (pathologically confirmed); LUSC cis rs10911251 0.508 rs944970 chr1:183112566 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg02931644 chr1:25747376 RHCE 0.39 7.18 0.37 4.61e-12 Erythrocyte sedimentation rate; LUSC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.76 13.57 0.6 1.04e-33 Age at first birth; LUSC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg06108461 chr20:60628389 TAF4 -0.99 -16.75 -0.68 4e-46 Body mass index; LUSC cis rs2204008 0.592 rs2320501 chr12:38145285 T/G cg13010199 chr12:38710504 ALG10B 0.64 9.82 0.47 3.64e-20 Bladder cancer; LUSC cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg22709100 chr7:91322751 NA -0.42 -6.12 -0.32 2.69e-9 Breast cancer; LUSC cis rs73198271 0.813 rs56007835 chr8:8610026 G/A cg01851573 chr8:8652454 MFHAS1 0.54 8.22 0.41 4.59e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6062509 0.895 rs6011040 chr20:62337406 C/T cg21849932 chr20:62369462 LIME1 0.43 6.53 0.34 2.5e-10 Prostate cancer; LUSC cis rs7927771 0.524 rs7942074 chr11:47720509 T/C cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.91e-10 Subjective well-being; LUSC cis rs7828089 0.875 rs6998575 chr8:22254499 C/T cg12081754 chr8:22256438 SLC39A14 0.62 10.22 0.49 1.68e-21 Verbal declarative memory; LUSC cis rs9457247 0.555 rs2247325 chr6:167369992 A/G cg07741184 chr6:167504864 NA -0.34 -5.98 -0.31 5.59e-9 Crohn's disease; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04720665 chr1:245028075 HNRNPU -0.41 -6.26 -0.32 1.15e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9303401 0.659 rs34275691 chr17:56736640 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.61 0.6 7.09e-34 Cognitive test performance; LUSC cis rs78456975 0.628 rs13426896 chr2:1554768 C/T cg01028140 chr2:1542097 TPO -0.61 -9.12 -0.45 7.42e-18 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs4595586 0.525 rs34204378 chr12:39425759 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.5 0.34 2.86e-10 Morning vs. evening chronotype; LUSC trans rs4713118 0.586 rs6905522 chr6:28086479 A/C cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Parkinson's disease; LUSC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.68 0.47 1.08e-19 Bipolar disorder; LUSC cis rs1595825 0.945 rs76877032 chr2:198840000 G/A cg10547527 chr2:198650123 BOLL -0.5 -5.85 -0.3 1.16e-8 Ulcerative colitis; LUSC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg20476274 chr7:133979776 SLC35B4 0.87 16.84 0.68 1.7e-46 Mean platelet volume; LUSC cis rs11971779 0.680 rs6960876 chr7:139112176 C/T cg23387468 chr7:139079360 LUC7L2 -0.4 -5.92 -0.31 8.12e-9 Diisocyanate-induced asthma; LUSC cis rs17818399 0.533 rs13420857 chr2:46798005 C/G cg02822958 chr2:46747628 ATP6V1E2 -0.36 -6.05 -0.31 3.92e-9 Height; LUSC trans rs2832191 0.740 rs2853830 chr21:30416824 A/G cg14791747 chr16:20752902 THUMPD1 -0.4 -6.13 -0.32 2.47e-9 Dental caries; LUSC cis rs713477 1.000 rs8010013 chr14:55884828 A/C cg04306507 chr14:55594613 LGALS3 -0.34 -6.82 -0.35 4.32e-11 Pediatric bone mineral content (femoral neck); LUSC trans rs61931739 0.534 rs12372721 chr12:34175301 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.52 0.42 5.57e-16 Morning vs. evening chronotype; LUSC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg09359103 chr1:154839909 KCNN3 -0.73 -17.4 -0.69 1.05e-48 Prostate cancer; LUSC cis rs2455601 0.671 rs2568091 chr11:8986048 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.27 -0.32 1.14e-9 Schizophrenia; LUSC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg00255919 chr5:131827918 IRF1 -0.42 -8.01 -0.4 1.97e-14 Asthma (sex interaction); LUSC cis rs2798269 0.867 rs2761909 chr13:22116804 T/C cg18095732 chr13:22033692 ZDHHC20 -0.41 -6.32 -0.33 8.19e-10 PR segment; LUSC cis rs17154702 0.510 rs7831224 chr8:8656647 C/T cg01851573 chr8:8652454 MFHAS1 0.56 7.7 0.39 1.54e-13 Neurocognitive impairment in HIV-1 infection (continuous); LUSC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg12560992 chr17:57184187 TRIM37 0.85 15.53 0.65 2.58e-41 Intelligence (multi-trait analysis); LUSC cis rs1443512 0.947 rs894739 chr12:54346869 T/C cg17410650 chr12:54324560 NA -0.44 -7.08 -0.36 8.37e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.56e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg17294928 chr15:75287854 SCAMP5 -0.76 -10.12 -0.48 3.67e-21 Blood trace element (Zn levels); LUSC cis rs2742417 0.603 rs7631818 chr3:45775931 A/T cg04837898 chr3:45731254 SACM1L -0.46 -7.41 -0.38 1.08e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9462846 0.691 rs9462853 chr6:42910666 T/C cg13397359 chr6:42928475 GNMT 0.43 5.93 0.31 7.54e-9 Blood protein levels; LUSC cis rs7804356 1.000 rs10272303 chr7:26827815 T/C cg03456212 chr7:26904342 SKAP2 -0.56 -6.63 -0.34 1.36e-10 Type 1 diabetes; LUSC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg20744362 chr22:50050164 C22orf34 0.4 8.33 0.41 2.15e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg02951883 chr7:2050386 MAD1L1 -0.44 -7.45 -0.38 8.19e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg25838465 chr1:92012736 NA 0.45 6.19 0.32 1.8e-9 Eosinophil percentage of white cells; LUSC cis rs1560104 0.709 rs9806831 chr16:12704395 A/G cg02946846 chr16:12632861 SNX29 0.32 5.83 0.3 1.28e-8 Obesity-related traits; LUSC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg15445000 chr17:37608096 MED1 0.4 6.7 0.34 8.76e-11 Glomerular filtration rate (creatinine); LUSC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg19046167 chr17:80928561 B3GNTL1 0.44 6.94 0.36 1.99e-11 Breast cancer; LUSC cis rs977987 0.806 rs2285225 chr16:75429252 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.02 -0.36 1.26e-11 Dupuytren's disease; LUSC cis rs17001868 0.568 rs9607702 chr22:40739177 A/G cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs9660992 0.762 rs1172129 chr1:205244972 T/A cg00857998 chr1:205179979 DSTYK 0.59 9.0 0.44 1.73e-17 Mean corpuscular volume;Mean platelet volume; LUSC trans rs4729127 1.000 rs12673727 chr7:93987809 G/A cg20086523 chr13:52378287 DHRS12 0.56 6.0 0.31 5.11e-9 Intelligence; LUSC cis rs4969178 0.965 rs12451715 chr17:76397334 A/C cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg05368731 chr17:41323189 NBR1 0.92 15.91 0.66 8.08e-43 Menopause (age at onset); LUSC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.74 -0.35 6.77e-11 Alzheimer's disease (late onset); LUSC cis rs9911578 0.813 rs8066773 chr17:56601552 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.4 6.08 0.32 3.2e-9 Intelligence (multi-trait analysis); LUSC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg07395648 chr5:131743802 NA -0.37 -5.71 -0.3 2.54e-8 Asthma (sex interaction); LUSC trans rs61931739 0.635 rs7979207 chr12:33910566 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.13 -0.32 2.45e-9 Morning vs. evening chronotype; LUSC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg13939156 chr17:80058883 NA -0.33 -6.56 -0.34 2.08e-10 Life satisfaction; LUSC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg18240062 chr17:79603768 NPLOC4 0.58 10.19 0.49 2.01e-21 Eye color traits; LUSC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg18512352 chr11:47633146 NA 0.48 9.98 0.48 1.03e-20 Subjective well-being; LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.83 0.35 3.98e-11 Platelet count; LUSC cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg01448562 chr3:133502909 NA -0.79 -14.05 -0.61 1.46e-35 Iron status biomarkers; LUSC cis rs8014204 0.587 rs6574201 chr14:75387256 T/C cg06637938 chr14:75390232 RPS6KL1 -0.85 -15.5 -0.65 3.37e-41 Caffeine consumption; LUSC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg27532560 chr4:187881888 NA -0.38 -6.27 -0.32 1.1e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.98 -0.31 5.62e-9 Neutrophil percentage of white cells; LUSC cis rs8048589 0.615 rs34098770 chr16:12237812 G/A cg02910054 chr16:12241554 SNX29 0.51 6.3 0.33 9.22e-10 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs2573652 0.657 rs2573668 chr15:100541776 C/T cg00587665 chr15:100533223 ADAMTS17 0.39 6.92 0.35 2.25e-11 Height; LUSC cis rs4363385 0.747 rs3753454 chr1:152973776 T/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.59 -0.38 3.15e-13 Inflammatory skin disease; LUSC cis rs250677 0.522 rs62378210 chr5:148384885 G/A cg18129178 chr5:148520854 ABLIM3 -0.51 -7.28 -0.37 2.42e-12 Breast cancer; LUSC cis rs7520050 0.966 rs12049588 chr1:46472422 G/A cg06784218 chr1:46089804 CCDC17 -0.29 -5.69 -0.3 2.78e-8 Red blood cell count;Reticulocyte count; LUSC cis rs6456156 0.586 rs9457261 chr6:167467679 A/G cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg11752832 chr7:134001865 SLC35B4 0.6 9.38 0.46 1.04e-18 Mean platelet volume; LUSC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -8.05 -0.4 1.49e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs864537 0.584 rs7523907 chr1:167427247 A/G cg22356347 chr1:167427500 CD247 -0.25 -5.81 -0.3 1.43e-8 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg03453431 chr7:157225567 NA -0.57 -10.42 -0.5 3.27e-22 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg12463550 chr7:65579703 CRCP -0.49 -7.11 -0.36 7.07e-12 Aortic root size; LUSC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg15212455 chr7:39170539 POU6F2 0.65 11.19 0.52 6.8e-25 IgG glycosylation; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg00024416 chr22:24240387 NA -0.32 -5.89 -0.31 9.24e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg21433313 chr16:3507492 NAT15 -0.41 -6.51 -0.34 2.71e-10 Body mass index (adult); LUSC cis rs11098499 0.866 rs6824111 chr4:120285968 T/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg23711669 chr6:146136114 FBXO30 0.83 14.71 0.63 4.06e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs10876993 0.890 rs7963927 chr12:58046272 T/G cg15848620 chr12:58087721 OS9 -0.51 -7.37 -0.37 1.34e-12 Celiac disease or Rheumatoid arthritis; LUSC cis rs2404602 0.647 rs11072619 chr15:77043242 A/C cg23625390 chr15:77176239 SCAPER -0.66 -10.06 -0.48 5.61e-21 Blood metabolite levels; LUSC cis rs6574644 0.920 rs12146979 chr14:81780859 A/G cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04165764 chr17:48074112 NA -0.4 -5.95 -0.31 6.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.37 5.83 0.3 1.34e-8 Vitiligo; LUSC cis rs4343996 0.754 rs6965684 chr7:3348223 A/T cg21248987 chr7:3385318 SDK1 0.37 6.37 0.33 6.31e-10 Motion sickness; LUSC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg12463550 chr7:65579703 CRCP 0.42 6.03 0.31 4.41e-9 Aortic root size; LUSC cis rs9300255 0.602 rs1790126 chr12:123683563 C/T cg00376283 chr12:123451042 ABCB9 0.64 8.15 0.41 7.56e-15 Neutrophil percentage of white cells; LUSC cis rs10743315 0.557 rs78468792 chr12:19351592 T/A cg02471346 chr12:19282374 PLEKHA5 0.78 6.28 0.33 1.02e-9 Gut microbiota (bacterial taxa); LUSC trans rs2587949 0.550 rs1825509 chr3:4207147 C/T cg15139668 chr4:4577005 NA -0.41 -6.03 -0.31 4.27e-9 Periodontitis (DPAL); LUSC cis rs1215050 0.740 rs1214997 chr4:99041533 A/T cg05340658 chr4:99064831 C4orf37 0.45 7.22 0.37 3.43e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9325144 0.624 rs10783329 chr12:39113951 C/T cg26384229 chr12:38710491 ALG10B -0.61 -9.48 -0.46 4.76e-19 Morning vs. evening chronotype; LUSC cis rs965469 1.000 rs1040727 chr20:3264292 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -5.93 -0.31 7.41e-9 IFN-related cytopenia; LUSC trans rs62103177 0.525 rs4283293 chr18:77759582 A/G cg05926928 chr17:57297772 GDPD1 -0.88 -10.12 -0.48 3.55e-21 Opioid sensitivity; LUSC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg10130564 chr11:117069849 TAGLN -0.38 -6.59 -0.34 1.71e-10 Blood protein levels; LUSC cis rs4622329 0.552 rs4764669 chr12:102288250 G/A cg23541617 chr12:102225335 GNPTAB 0.27 6.38 0.33 5.92e-10 Systemic lupus erythematosus; LUSC cis rs11122272 0.668 rs2790874 chr1:231537988 A/G cg06096015 chr1:231504339 EGLN1 0.56 9.84 0.47 3.23e-20 Hemoglobin concentration; LUSC cis rs2835872 0.828 rs73220495 chr21:38989712 G/A cg20424643 chr21:39039972 KCNJ6 0.37 5.78 0.3 1.74e-8 Electroencephalographic traits in alcoholism; LUSC cis rs34779708 0.931 rs4934721 chr10:35377715 A/G cg03585969 chr10:35415529 CREM 0.64 8.96 0.44 2.3e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs6842047 1.000 rs1511800 chr4:187135556 C/T cg00427296 chr17:8534932 MYH10 -0.55 -6.09 -0.32 3.04e-9 Blood protein levels; LUSC cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg13010199 chr12:38710504 ALG10B 0.6 9.78 0.47 4.97e-20 Morning vs. evening chronotype; LUSC cis rs752010 0.619 rs6702659 chr1:42112236 T/C cg06885757 chr1:42089581 HIVEP3 0.57 11.75 0.54 6.68e-27 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9462027 0.606 rs12201281 chr6:34681091 T/C cg07306190 chr6:34760872 UHRF1BP1 0.33 5.79 0.3 1.65e-8 Systemic lupus erythematosus; LUSC cis rs7572644 0.680 rs12465012 chr2:28028191 C/T cg27432699 chr2:27873401 GPN1 0.55 7.3 0.37 2.19e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg26384229 chr12:38710491 ALG10B 0.81 13.8 0.6 1.33e-34 Drug-induced liver injury (flucloxacillin); LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg26314531 chr2:26401878 FAM59B -0.67 -8.88 -0.44 4.2e-17 Gut microbiome composition (summer); LUSC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.25 -0.32 1.26e-9 Extrinsic epigenetic age acceleration; LUSC cis rs669446 0.533 rs28833034 chr1:44212942 A/G cg15962314 chr1:44399869 ARTN 0.24 5.73 0.3 2.28e-8 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs2658782 1.000 rs2019814 chr11:93168885 A/G cg15737290 chr11:93063684 CCDC67 0.66 8.09 0.4 1.15e-14 Pulmonary function decline; LUSC cis rs1577917 1.000 rs35385043 chr6:86648546 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13389229 chr3:49449900 RHOA;TCTA -0.45 -6.09 -0.32 3.09e-9 Hepatitis; LUSC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg06713675 chr4:122721982 EXOSC9 -0.45 -7.96 -0.4 2.76e-14 Type 2 diabetes; LUSC cis rs273573 0.961 rs163854 chr11:30964632 G/T cg06552810 chr11:31128660 NA 0.33 5.73 0.3 2.23e-8 Total body bone mineral density; LUSC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11098499 0.865 rs28845498 chr4:120405186 G/A cg24375607 chr4:120327624 NA 0.79 11.91 0.55 1.72e-27 Corneal astigmatism; LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg04398451 chr17:18023971 MYO15A -0.44 -6.97 -0.36 1.68e-11 Total body bone mineral density; LUSC cis rs5753618 0.539 rs2228619 chr22:31663842 C/G cg22777020 chr22:31556080 RNF185 -0.46 -5.84 -0.3 1.26e-8 Colorectal cancer; LUSC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.75 9.31 0.45 1.77e-18 Gut microbiome composition (summer); LUSC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg07701084 chr6:150067640 NUP43 0.53 8.14 0.41 8.16e-15 Lung cancer; LUSC cis rs7107174 0.892 rs12284390 chr11:78103902 C/A cg02023728 chr11:77925099 USP35 0.46 6.7 0.34 8.82e-11 Testicular germ cell tumor; LUSC cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.91e-16 Menopause (age at onset); LUSC cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs600231 0.665 rs1621277 chr11:65221954 A/G cg21890820 chr11:65308645 LTBP3 -0.53 -7.93 -0.4 3.33e-14 Bone mineral density; LUSC cis rs4474465 0.646 rs7927503 chr11:78280606 G/T cg27205649 chr11:78285834 NARS2 0.58 7.18 0.37 4.52e-12 Alzheimer's disease (survival time); LUSC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.1 0.48 4.25e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3733585 0.563 rs881971 chr4:9930962 A/G cg26043149 chr18:55253948 FECH -0.42 -6.58 -0.34 1.84e-10 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg23590916 chr17:43697445 MGC57346 -0.49 -6.58 -0.34 1.8e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9527 0.535 rs4917999 chr10:104963051 C/G cg04362960 chr10:104952993 NT5C2 -0.65 -10.26 -0.49 1.19e-21 Arsenic metabolism; LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg26314531 chr2:26401878 FAM59B -0.7 -9.93 -0.48 1.56e-20 Gut microbiome composition (summer); LUSC cis rs30380 0.632 rs26498 chr5:96138812 C/T cg16492584 chr5:96139282 ERAP1 0.56 7.55 0.38 4.28e-13 Cerebrospinal fluid biomarker levels; LUSC trans rs7819412 0.540 rs2409726 chr8:11043138 T/C cg08975724 chr8:8085496 FLJ10661 -0.43 -5.99 -0.31 5.44e-9 Triglycerides; LUSC cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg23711669 chr6:146136114 FBXO30 -0.77 -13.82 -0.6 1.17e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs9318086 0.687 rs9507182 chr13:24442365 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.42 6.36 0.33 6.71e-10 Myopia (pathological); LUSC cis rs6704644 0.719 rs72980376 chr2:234373368 C/T cg05711037 chr2:234359783 DGKD 0.66 6.49 0.33 3.14e-10 Bilirubin levels; LUSC cis rs983392 0.836 rs72918674 chr11:59944580 C/T cg20284999 chr11:59952153 MS4A6A -0.38 -6.24 -0.32 1.29e-9 Alzheimer's disease (late onset); LUSC cis rs6740322 0.895 rs6738717 chr2:43573670 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -7.16 -0.36 5.05e-12 Coronary artery disease; LUSC cis rs4808199 0.894 rs10418051 chr19:19397789 C/T cg03709012 chr19:19516395 GATAD2A 0.93 11.5 0.53 5.11e-26 Nonalcoholic fatty liver disease; LUSC cis rs11166629 1.000 rs966659 chr8:135639045 C/T cg27224718 chr8:135614730 ZFAT -0.66 -10.93 -0.51 5.6e-24 Smoking quantity; LUSC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg16545954 chr1:2118288 C1orf86 0.32 6.22 0.32 1.45e-9 Height; LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9611519 0.929 rs9611474 chr22:41434858 G/A cg13813247 chr22:41461852 NA -0.36 -6.52 -0.34 2.53e-10 Neuroticism; LUSC cis rs2798269 0.933 rs2476639 chr13:22137266 T/G cg18095732 chr13:22033692 ZDHHC20 -0.4 -6.06 -0.31 3.72e-9 PR segment; LUSC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg03060546 chr3:49711283 APEH -0.44 -6.17 -0.32 1.93e-9 Menarche (age at onset); LUSC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 9.11 0.45 7.62e-18 Tonsillectomy; LUSC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg16680214 chr1:154839983 KCNN3 -0.57 -11.1 -0.52 1.46e-24 Prostate cancer; LUSC cis rs554111 0.656 rs6695218 chr1:21190512 A/C cg01072550 chr1:21505969 NA 0.41 6.32 0.33 8.51e-10 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4253772 1.000 rs4253766 chr22:46623905 C/T cg00784671 chr22:46762841 CELSR1 -0.42 -5.69 -0.3 2.82e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg02038168 chr22:39784481 NA -0.45 -6.84 -0.35 3.82e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs908922 0.676 rs1538082 chr1:152517304 A/G cg20991723 chr1:152506922 NA 0.5 9.35 0.46 1.32e-18 Hair morphology; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13602813 chr3:13920840 WNT7A 0.45 7.14 0.36 5.99e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs713587 0.525 rs1541984 chr2:25082414 G/A cg01884057 chr2:25150051 NA 0.43 9.76 0.47 5.79e-20 Body mass index in non-asthmatics; LUSC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg11062466 chr8:58055876 NA -0.65 -8.35 -0.42 1.87e-15 Developmental language disorder (linguistic errors); LUSC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg21862992 chr11:68658383 NA 0.45 7.23 0.37 3.32e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg06873352 chr17:61820015 STRADA 0.56 8.72 0.43 1.35e-16 Height; LUSC cis rs11031096 0.678 rs970329 chr11:4189803 G/T cg18678763 chr11:4115507 RRM1 -0.41 -5.76 -0.3 1.96e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4654899 0.680 rs11805006 chr1:21249603 C/T cg01072550 chr1:21505969 NA -0.54 -8.16 -0.41 7.05e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.51 -0.38 5.34e-13 Bipolar disorder; LUSC cis rs72960926 0.744 rs72952257 chr6:74924073 A/G cg03266952 chr6:74778945 NA -0.84 -7.01 -0.36 1.34e-11 Metabolite levels (MHPG); LUSC trans rs61931739 0.517 rs11611190 chr12:34015697 G/A cg26384229 chr12:38710491 ALG10B 0.73 11.38 0.53 1.4e-25 Morning vs. evening chronotype; LUSC cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg06454157 chr6:167490870 NA -0.26 -6.26 -0.32 1.2e-9 Crohn's disease; LUSC cis rs4237845 0.804 rs10877034 chr12:58286444 T/C cg00677455 chr12:58241039 CTDSP2 0.49 7.42 0.38 9.56e-13 Intelligence (multi-trait analysis); LUSC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg22875332 chr1:76189707 ACADM 0.84 14.89 0.63 7.84e-39 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs8040855 0.965 rs11073990 chr15:85711301 C/T cg00988175 chr11:59481031 OR10V1 0.29 6.24 0.32 1.35e-9 Bulimia nervosa; LUSC cis rs9311676 0.656 rs4399910 chr3:58389809 A/G cg13750441 chr3:58318267 PXK 0.35 6.76 0.35 6.2e-11 Systemic lupus erythematosus; LUSC cis rs2625529 0.730 rs1481860 chr15:72241857 T/C cg16672083 chr15:72433130 SENP8 0.5 7.99 0.4 2.24e-14 Red blood cell count; LUSC cis rs6500602 0.702 rs6500605 chr16:4502410 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.48 6.38 0.33 6.06e-10 Schizophrenia; LUSC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.68e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg26384229 chr12:38710491 ALG10B 0.88 14.82 0.63 1.57e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg20243544 chr17:37824526 PNMT 0.48 6.73 0.35 7.42e-11 Asthma; LUSC cis rs1506636 0.962 rs2896335 chr7:123376855 A/T cg03229431 chr7:123269106 ASB15 -0.65 -10.57 -0.5 9.99e-23 Plateletcrit;Platelet count; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs7824557 1.000 rs7824557 chr8:11104111 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.64 -0.39 2.3e-13 Retinal vascular caliber; LUSC cis rs6582630 0.538 rs8189550 chr12:38333058 T/G cg26384229 chr12:38710491 ALG10B -0.53 -7.9 -0.4 4.2e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs2710642 0.671 rs13009169 chr2:63405218 G/A cg17519650 chr2:63277830 OTX1 -0.5 -6.8 -0.35 4.72e-11 LDL cholesterol levels;LDL cholesterol; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg21782813 chr7:2030301 MAD1L1 0.47 8.04 0.4 1.55e-14 Bipolar disorder and schizophrenia; LUSC cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg24450063 chr1:156163899 SLC25A44 1.04 22.7 0.78 1.14e-69 Testicular germ cell tumor; LUSC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg08847533 chr14:75593920 NEK9 -0.8 -13.67 -0.6 4.11e-34 Height; LUSC cis rs3809566 0.710 rs4075583 chr15:63340227 C/T cg05507819 chr15:63340323 TPM1 0.46 6.41 0.33 5.07e-10 Platelet count; LUSC cis rs34779708 0.966 rs35146199 chr10:35460939 T/C cg03585969 chr10:35415529 CREM 0.62 8.91 0.44 3.28e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg00409905 chr10:38381863 ZNF37A -0.38 -6.49 -0.33 3.17e-10 Extrinsic epigenetic age acceleration; LUSC cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.43 5.82 0.3 1.41e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs17539620 0.624 rs62432738 chr6:154835674 T/C cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg07701084 chr6:150067640 NUP43 0.57 8.9 0.44 3.61e-17 Lung cancer; LUSC cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg06784218 chr1:46089804 CCDC17 0.54 10.88 0.51 8.41e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs11098499 0.954 rs7656252 chr4:120404268 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.05 0.4 1.44e-14 Corneal astigmatism; LUSC cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg00321850 chr1:175162397 KIAA0040 0.46 7.83 0.39 6.5e-14 Alcohol dependence; LUSC cis rs9952991 0.941 rs1893217 chr18:12809340 A/G cg23598886 chr18:12777645 NA -0.57 -5.7 -0.3 2.67e-8 Inflammatory skin disease; LUSC cis rs10751667 0.961 rs6597953 chr11:991099 G/A ch.11.42038R chr11:967971 AP2A2 0.53 7.76 0.39 1.05e-13 Alzheimer's disease (late onset); LUSC cis rs61931739 0.817 rs866515 chr12:34215479 A/G cg06521331 chr12:34319734 NA -0.38 -6.44 -0.33 4.28e-10 Morning vs. evening chronotype; LUSC cis rs2204008 0.576 rs11519979 chr12:37999413 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.9 0.66 8.5e-43 Bladder cancer; LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg27170947 chr2:26402098 FAM59B 0.73 10.81 0.51 1.45e-23 Gut microbiome composition (summer); LUSC cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg25457927 chr22:38595422 NA -0.4 -8.42 -0.42 1.11e-15 Cutaneous nevi; LUSC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg18904891 chr8:8559673 CLDN23 0.41 5.89 0.31 9.22e-9 Neuroticism; LUSC cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg11189052 chr15:85197271 WDR73 -0.44 -6.36 -0.33 6.53e-10 P wave terminal force; LUSC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg17366294 chr4:99064904 C4orf37 0.56 9.8 0.47 4.42e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.38 0.49 4.47e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 1.000 rs4727267 chr7:91570290 G/C cg22709100 chr7:91322751 NA -0.38 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg18351406 chr4:77819688 ANKRD56 0.46 6.39 0.33 5.46e-10 Emphysema distribution in smoking; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.61 0.54 2.17e-26 Alzheimer's disease; LUSC cis rs703842 0.739 rs701008 chr12:58117645 A/G cg18357645 chr12:58087776 OS9 -0.41 -5.76 -0.3 1.87e-8 Multiple sclerosis; LUSC cis rs17253792 0.822 rs13379353 chr14:56050478 G/C cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11890956 chr21:40555474 PSMG1 1.03 20.27 0.74 3.82e-60 Cognitive function; LUSC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg10792982 chr14:105748885 BRF1 0.5 8.84 0.44 5.56e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs4843185 0.576 rs380996 chr16:85728813 A/G cg05245094 chr16:85669572 KIAA0182 -0.42 -6.45 -0.33 3.99e-10 Platelet distribution width; LUSC cis rs4631830 0.900 rs10763546 chr10:51536399 C/G cg16070123 chr10:51489643 NA -0.5 -7.99 -0.4 2.18e-14 Prostate-specific antigen levels; LUSC cis rs1443512 0.812 rs2078098 chr12:54337527 C/A cg17410650 chr12:54324560 NA -0.58 -10.18 -0.49 2.21e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs939658 0.683 rs8024572 chr15:79465600 A/G cg17916960 chr15:79447300 NA 0.39 7.16 0.36 5.18e-12 Refractive error; LUSC cis rs9486719 0.947 rs9386648 chr6:97035656 T/C cg06623918 chr6:96969491 KIAA0776 -0.84 -10.4 -0.49 3.86e-22 Migraine;Coronary artery disease; LUSC cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg07817648 chr10:79422355 NA 0.5 7.13 0.36 6.36e-12 Bone mineral density; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.65 0.76 1.42e-65 Prudent dietary pattern; LUSC cis rs2742417 0.603 rs2742458 chr3:45767602 C/T cg04837898 chr3:45731254 SACM1L -0.45 -7.26 -0.37 2.66e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9650315 0.929 rs72656020 chr8:57166349 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.52 7.2 0.37 3.99e-12 Height; LUSC cis rs2070488 0.775 rs7649984 chr3:38570221 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.66 -11.39 -0.53 1.28e-25 Electrocardiographic conduction measures; LUSC cis rs1107366 1.000 rs1107364 chr3:125904263 G/A cg20988073 chr3:125900093 ALDH1L1 -0.3 -6.04 -0.31 4.02e-9 Metabolite levels; LUSC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg00121533 chr1:75199117 CRYZ;TYW3 0.49 7.81 0.39 7.54e-14 Resistin levels; LUSC cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg03146154 chr1:46216737 IPP 0.56 8.39 0.42 1.36e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4919687 0.577 rs12765459 chr10:104465687 G/C cg04362960 chr10:104952993 NT5C2 0.49 6.67 0.34 1.08e-10 Colorectal cancer; LUSC cis rs7727544 0.716 rs11949055 chr5:131576737 T/C cg04518342 chr5:131593106 PDLIM4 0.32 5.88 0.31 9.85e-9 Blood metabolite levels; LUSC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.83 0.39 6.53e-14 Blood metabolite levels; LUSC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.04 0.4 1.61e-14 Parkinson's disease; LUSC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs3796619 0.961 rs62294748 chr4:1082999 G/A cg27284194 chr4:1044797 NA 0.52 8.55 0.42 4.34e-16 Recombination rate (males); LUSC cis rs2637266 0.935 rs1866890 chr10:78397073 C/T cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.95e-13 Pulmonary function; LUSC cis rs6845621 0.745 rs11737348 chr4:18855589 G/C cg12196642 chr4:18937545 NA -0.31 -5.82 -0.3 1.39e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9304742 0.611 rs10415443 chr19:53464864 C/G cg09915433 chr19:53449742 NA -0.5 -7.87 -0.4 4.9e-14 Psoriasis; LUSC cis rs929596 0.564 rs2602362 chr2:234516548 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -6.07 -0.32 3.45e-9 Total bilirubin levels in HIV-1 infection; LUSC cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg08999081 chr20:33150536 PIGU 0.38 6.8 0.35 4.87e-11 Height; LUSC trans rs877282 1.000 rs11253366 chr10:773386 C/T cg22713356 chr15:30763199 NA 1.08 15.38 0.64 9.93e-41 Uric acid levels; LUSC trans rs11250098 0.574 rs4240672 chr8:10767917 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -7.28 -0.37 2.41e-12 Morning vs. evening chronotype; LUSC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg21770322 chr7:97807741 LMTK2 0.41 7.03 0.36 1.2e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg20573242 chr4:122745356 CCNA2 0.43 6.53 0.34 2.45e-10 Type 2 diabetes; LUSC trans rs3942852 0.568 rs10838800 chr11:48094879 C/T cg03929089 chr4:120376271 NA -0.58 -7.46 -0.38 7.43e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs1865721 0.958 rs11663060 chr18:73172806 T/C cg26385618 chr18:73139727 C18orf62 -0.47 -7.87 -0.4 4.85e-14 Intelligence; LUSC cis rs9905704 0.633 rs4793588 chr17:56471051 G/T cg19466818 chr17:56409534 MIR142 0.33 6.13 0.32 2.42e-9 Testicular germ cell tumor; LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.58 0.38 3.46e-13 Bipolar disorder; LUSC cis rs936229 0.861 rs12441505 chr15:75107311 A/C cg10253484 chr15:75165896 SCAMP2 -0.54 -7.36 -0.37 1.46e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7903847 0.632 rs11189157 chr10:99113729 G/A cg20016023 chr10:99160130 RRP12 -0.29 -6.25 -0.32 1.22e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg04455712 chr21:45112962 RRP1B 0.45 8.56 0.42 4.04e-16 Mean corpuscular volume; LUSC cis rs559928 0.597 rs2096706 chr11:63924446 T/G cg05555928 chr11:63887634 MACROD1 -0.52 -6.35 -0.33 7.06e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg17385448 chr1:15911702 AGMAT 0.35 6.01 0.31 4.81e-9 Systolic blood pressure; LUSC cis rs6867913 0.709 rs2338874 chr5:141466926 G/A cg23435118 chr5:141488016 NDFIP1 -0.44 -6.92 -0.35 2.29e-11 Asthma; LUSC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg11764359 chr7:65958608 NA 0.52 6.7 0.34 8.95e-11 Aortic root size; LUSC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg02773041 chr1:40204384 PPIE 0.5 7.47 0.38 7.15e-13 Blood protein levels; LUSC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg04362960 chr10:104952993 NT5C2 0.58 9.16 0.45 5.32e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23260255 chr3:187871479 LPP 0.47 6.85 0.35 3.63e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg12463550 chr7:65579703 CRCP -0.55 -8.09 -0.4 1.11e-14 Aortic root size; LUSC cis rs12618769 0.625 rs3769726 chr2:99105827 G/C cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs10779751 1.000 rs4845982 chr1:11271576 T/C cg08854313 chr1:11322531 MTOR 0.86 14.99 0.63 3.25e-39 Body mass index; LUSC cis rs6835098 0.961 rs1574314 chr4:174106663 C/T cg08422745 chr4:174089978 GALNT7 -0.8 -12.95 -0.58 2.24e-31 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg16339924 chr4:17578868 LAP3 0.55 8.53 0.42 5.11e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23106890 chr6:49431067 CENPQ;MUT -0.43 -6.32 -0.33 8.18e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs67311347 1.000 rs9842564 chr3:40405810 A/G cg09455208 chr3:40491958 NA -0.49 -8.47 -0.42 7.78e-16 Renal cell carcinoma; LUSC cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg10370574 chr19:1840461 REXO1 0.55 7.96 0.4 2.67e-14 Bipolar disorder; LUSC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg16339924 chr4:17578868 LAP3 0.57 8.79 0.43 8.02e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 1.000 rs4813566 chr20:25386465 G/T cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg16362232 chr11:430036 ANO9 0.64 8.11 0.41 9.91e-15 Body mass index; LUSC cis rs11112613 0.713 rs11112591 chr12:105951620 C/T cg03607813 chr12:105948248 NA 0.78 11.89 0.55 1.96e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg22382663 chr15:68346430 PIAS1 0.45 6.68 0.34 9.76e-11 Calcium levels; LUSC cis rs17155006 0.612 rs435361 chr7:107738552 C/T cg05962710 chr7:107745446 LAMB4 -0.36 -6.3 -0.33 9.63e-10 Pneumococcal bacteremia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25080152 chr8:128748155 MYC 0.44 6.72 0.35 8.03e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3916 1.000 rs1799958 chr12:121176083 G/A cg02419362 chr12:121203948 SPPL3 0.36 5.65 0.3 3.5e-8 Urinary metabolites (H-NMR features); LUSC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg23985595 chr17:80112537 CCDC57 0.3 5.79 0.3 1.66e-8 Life satisfaction; LUSC cis rs2692947 0.526 rs58719199 chr2:96578247 G/A cg22654517 chr2:96458247 NA 0.37 6.93 0.35 2.17e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg10802521 chr3:52805072 NEK4 -0.52 -8.46 -0.42 8.21e-16 Bipolar disorder; LUSC cis rs9650315 0.778 rs56181002 chr8:57158384 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.57 7.54 0.38 4.5e-13 Height; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -6.36 -0.33 6.74e-10 Longevity;Endometriosis; LUSC cis rs7683537 0.673 rs1401363 chr4:185643862 A/G cg04058563 chr4:185651563 MLF1IP 0.85 13.2 0.59 2.59e-32 Systemic lupus erythematosus; LUSC trans rs6076960 0.684 rs6038408 chr20:6268983 A/C cg17788362 chr6:86352627 SYNCRIP 0.52 7.61 0.38 2.75e-13 Smooth-surface caries; LUSC cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg16339924 chr4:17578868 LAP3 0.66 10.35 0.49 6e-22 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00260888 chr20:30865478 KIF3B 0.43 6.93 0.35 2.18e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72781680 0.846 rs55770503 chr2:24030126 A/T cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.45e-8 Lymphocyte counts; LUSC cis rs950776 0.518 rs12907169 chr15:78825498 G/C cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs7568458 0.783 rs1561198 chr2:85809989 C/T cg02493740 chr2:85810744 VAMP5 -0.38 -7.02 -0.36 1.21e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs17270561 0.779 rs17271767 chr6:25886921 C/T cg17042849 chr6:26104293 HIST1H4C -0.47 -5.85 -0.3 1.18e-8 Iron status biomarkers; LUSC trans rs7647973 0.710 rs2029591 chr3:49646981 C/T cg21659725 chr3:3221576 CRBN 0.66 7.57 0.38 3.62e-13 Menarche (age at onset); LUSC trans rs853679 0.607 rs34243448 chr6:28193102 C/A cg01620082 chr3:125678407 NA -0.86 -7.49 -0.38 6.36e-13 Depression; LUSC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg12310025 chr6:25882481 NA -0.62 -10.31 -0.49 8.31e-22 Intelligence (multi-trait analysis); LUSC cis rs79387448 1.000 rs79387448 chr2:103215410 C/T cg09003973 chr2:102972529 NA 0.77 7.41 0.38 1.05e-12 Gut microbiota (bacterial taxa); LUSC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg17366294 chr4:99064904 C4orf37 0.6 10.76 0.51 2.18e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg15744005 chr10:104629667 AS3MT -0.39 -7.98 -0.4 2.29e-14 Arsenic metabolism; LUSC cis rs472402 0.580 rs3736316 chr5:6656210 G/A cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.54 -7.77 -0.39 9.73e-14 Response to amphetamines; LUSC cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg11062466 chr8:58055876 NA 0.47 6.28 0.32 1.07e-9 Developmental language disorder (linguistic errors); LUSC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg17143192 chr8:8559678 CLDN23 -0.64 -9.42 -0.46 7.43e-19 Obesity-related traits; LUSC cis rs909002 0.962 rs1474181 chr1:32136610 C/G cg13919466 chr1:32135498 COL16A1 -0.34 -6.35 -0.33 7e-10 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg24562669 chr7:97807699 LMTK2 0.37 6.45 0.33 3.99e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.96 0.61 3.35e-35 Platelet count; LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg16647868 chr5:131706066 SLC22A5 -0.38 -5.81 -0.3 1.45e-8 Breast cancer; LUSC cis rs11209002 0.567 rs2755268 chr1:67539881 T/C cg02640540 chr1:67518911 SLC35D1 0.62 8.59 0.43 3.33e-16 Crohn's disease; LUSC cis rs1775715 0.707 rs2808073 chr10:32179275 A/G cg04359828 chr10:32216031 ARHGAP12 0.37 6.31 0.33 8.87e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9768139 0.708 rs11769028 chr7:158113881 G/A cg25566285 chr7:158114605 PTPRN2 0.35 6.53 0.34 2.52e-10 Calcium levels; LUSC cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.82 0.43 6.31e-17 Axial length; LUSC cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg22117172 chr7:91764530 CYP51A1 0.32 5.77 0.3 1.81e-8 Breast cancer; LUSC cis rs9921222 0.521 rs757460 chr16:367174 G/C cg00101154 chr16:420108 MRPL28 -0.4 -6.13 -0.32 2.42e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs12145833 0.596 rs12026068 chr1:243440352 A/G cg02356786 chr1:243265016 LOC731275 0.66 6.32 0.33 8.59e-10 Obesity (early onset extreme); LUSC cis rs9653442 0.545 rs10496344 chr2:100764125 C/T cg22139774 chr2:100720529 AFF3 0.42 7.26 0.37 2.79e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs5769707 0.616 rs135869 chr22:50008366 T/C cg20744362 chr22:50050164 C22orf34 0.39 7.08 0.36 8.47e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg20891558 chr2:74357851 NA 0.8 12.82 0.57 7.09e-31 Gestational age at birth (maternal effect); LUSC cis rs8060686 0.641 rs79719939 chr16:68240216 A/G cg27539214 chr16:67997921 SLC12A4 -0.56 -7.19 -0.37 4.36e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg00800038 chr16:89945340 TCF25 0.74 6.81 0.35 4.55e-11 Skin colour saturation; LUSC cis rs4622329 0.636 rs4764670 chr12:102288867 A/G cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC cis rs7909074 0.831 rs7903412 chr10:45382361 C/T cg04218760 chr10:45406644 TMEM72 -0.28 -6.85 -0.35 3.52e-11 Mean corpuscular volume; LUSC cis rs1712517 0.771 rs2292807 chr10:105155645 T/C cg05636881 chr10:105038444 INA 0.42 7.04 0.36 1.13e-11 Migraine; LUSC cis rs4474465 0.850 rs7942371 chr11:78219975 A/G cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.88 12.55 0.57 7.26e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs559928 0.606 rs60394481 chr11:63909035 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.19 0.37 4.21e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7605827 0.930 rs3792578 chr2:15534642 G/A cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg24881330 chr22:46731750 TRMU 0.73 5.98 0.31 5.59e-9 Body mass index; LUSC cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg12310025 chr6:25882481 NA -0.34 -5.88 -0.31 9.73e-9 Height; LUSC cis rs12477438 0.520 rs13031919 chr2:99848932 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.94 16.39 0.67 1.04e-44 Chronic sinus infection; LUSC cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg16322792 chr1:120165303 ZNF697 0.7 14.56 0.62 1.52e-37 Systemic lupus erythematosus; LUSC cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg07606381 chr6:8435919 SLC35B3 -0.72 -12.05 -0.55 5.1e-28 Motion sickness; LUSC trans rs1133146 1.000 rs1133146 chr19:53666660 A/G cg04114473 chr14:102976357 ANKRD9 -0.39 -6.44 -0.33 4.06e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs6977660 1.000 rs4719584 chr7:19823388 T/C cg05791153 chr7:19748676 TWISTNB 0.52 5.75 0.3 2.01e-8 Thyroid stimulating hormone; LUSC cis rs7615316 1.000 rs6440098 chr3:142355410 A/C cg16271453 chr3:142027066 XRN1 0.35 6.24 0.32 1.29e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9398803 0.865 rs4559102 chr6:126773580 G/A cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.96e-9 Male-pattern baldness; LUSC cis rs7843479 0.965 rs3816786 chr8:21860425 A/T cg17168535 chr8:21777572 XPO7 0.65 9.39 0.46 9.5e-19 Mean corpuscular volume; LUSC cis rs7577851 0.579 rs67016706 chr2:69548495 T/G cg10773587 chr2:69614142 GFPT1 0.59 6.36 0.33 6.58e-10 Parkinson's disease (age of onset); LUSC cis rs6696846 0.716 rs6593921 chr1:205062861 A/G cg21545522 chr1:205238299 TMCC2 0.43 8.16 0.41 7.02e-15 Red blood cell count; LUSC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg20503657 chr10:835505 NA 0.98 13.91 0.61 5.29e-35 Eosinophil percentage of granulocytes; LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg16393715 chr7:1948819 MAD1L1 0.37 6.36 0.33 6.82e-10 Bipolar disorder and schizophrenia; LUSC cis rs9815354 0.680 rs73073290 chr3:42027684 T/G cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs1595825 0.891 rs35817167 chr2:198718928 A/T cg00982548 chr2:198649783 BOLL -0.58 -7.27 -0.37 2.59e-12 Ulcerative colitis; LUSC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg10053473 chr17:62856997 LRRC37A3 -0.67 -10.5 -0.5 1.8e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.35 5.82 0.3 1.4e-8 Neutrophil percentage of white cells; LUSC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg26380479 chr7:97908229 NA -0.27 -6.14 -0.32 2.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs931127 0.658 rs7926512 chr11:65464487 T/A cg05805236 chr11:65401703 PCNXL3 -0.41 -7.08 -0.36 8.52e-12 Systemic lupus erythematosus; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.4e-14 Prudent dietary pattern; LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg00431813 chr7:1051703 C7orf50 -0.44 -7.11 -0.36 7.21e-12 Longevity;Endometriosis; LUSC cis rs868036 0.634 rs8028313 chr15:68043057 C/G cg24579218 chr15:68104479 NA -0.36 -6.28 -0.32 1.05e-9 Restless legs syndrome; LUSC cis rs1538970 0.924 rs1826691 chr1:45881262 A/G cg05343316 chr1:45956843 TESK2 -0.63 -8.79 -0.43 7.84e-17 Platelet count; LUSC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.85 -0.44 5.26e-17 Gut microbiome composition (summer); LUSC cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg08999081 chr20:33150536 PIGU -0.51 -10.33 -0.49 7e-22 Glomerular filtration rate (creatinine); LUSC cis rs968451 0.552 rs715505 chr22:39751251 G/C cg17798944 chr22:39715225 SNORD43;RPL3 0.54 6.72 0.34 8.07e-11 Primary biliary cholangitis; LUSC cis rs806215 1.000 rs698406 chr7:127255285 C/G cg25922125 chr7:127225783 GCC1 0.57 7.1 0.36 7.44e-12 Type 2 diabetes; LUSC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg06481639 chr22:41940642 POLR3H -0.52 -6.03 -0.31 4.38e-9 Vitiligo; LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.22 0.61 3.35e-36 Platelet count; LUSC cis rs7615316 0.899 rs4597728 chr3:142200809 T/C cg16271453 chr3:142027066 XRN1 -0.4 -6.87 -0.35 3.22e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4285028 0.796 rs12638492 chr3:121711763 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -9.01 -0.44 1.68e-17 Multiple sclerosis; LUSC cis rs372883 0.648 rs1003772 chr21:30736145 A/T cg08807101 chr21:30365312 RNF160 0.72 11.55 0.53 3.34e-26 Pancreatic cancer; LUSC cis rs1448094 0.872 rs7313373 chr12:86398370 C/G cg02569458 chr12:86230093 RASSF9 0.41 6.68 0.34 1.03e-10 Major depressive disorder; LUSC cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg13010199 chr12:38710504 ALG10B 0.63 9.82 0.47 3.75e-20 Bladder cancer; LUSC cis rs7267979 1.000 rs7267979 chr20:25298087 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.88 19.88 0.74 1.33e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12667521 chr19:29218732 NA 0.61 8.77 0.43 9.02e-17 Methadone dose in opioid dependence; LUSC cis rs1865760 0.865 rs10946800 chr6:25957773 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 6.91 0.35 2.42e-11 Height; LUSC cis rs11098499 0.644 rs34835603 chr4:120553428 C/T cg24375607 chr4:120327624 NA 0.72 11.49 0.53 5.61e-26 Corneal astigmatism; LUSC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg02269571 chr22:50332266 NA 0.59 8.71 0.43 1.44e-16 Schizophrenia; LUSC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg05585544 chr11:47624801 NA -0.42 -7.36 -0.37 1.45e-12 Subjective well-being; LUSC cis rs1023500 0.573 rs133378 chr22:42467695 G/C cg15557168 chr22:42548783 NA -0.45 -6.86 -0.35 3.26e-11 Schizophrenia; LUSC cis rs13004237 1 rs13004237 chr2:172833139 A/G cg13550731 chr2:172543902 DYNC1I2 -0.73 -11.49 -0.53 5.8e-26 Schizophrenia; LUSC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg25427524 chr10:38739819 LOC399744 -0.69 -12.63 -0.57 3.54e-30 Extrinsic epigenetic age acceleration; LUSC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg08508325 chr11:3079039 CARS -0.5 -12.49 -0.56 1.18e-29 Longevity; LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC trans rs1728785 0.688 rs698718 chr16:68560185 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs6964587 1.000 rs6952389 chr7:91657994 A/G cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.71e-18 Breast cancer; LUSC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg14004847 chr7:1930337 MAD1L1 -0.58 -8.88 -0.44 4.24e-17 Schizophrenia; LUSC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.04e-10 Monobrow; LUSC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg23649088 chr2:200775458 C2orf69 -0.55 -7.49 -0.38 6.12e-13 Schizophrenia; LUSC cis rs7072216 0.727 rs7913541 chr10:100172479 A/G cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg06636001 chr8:8085503 FLJ10661 0.46 7.05 0.36 1.06e-11 Mood instability; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg20160885 chr7:5013524 RNF216L 0.48 5.97 0.31 5.92e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg11764359 chr7:65958608 NA 0.61 9.2 0.45 3.85e-18 Aortic root size; LUSC cis rs965469 1.000 rs6037556 chr20:3317890 G/C cg25506879 chr20:3388711 C20orf194 -0.51 -5.68 -0.3 2.97e-8 IFN-related cytopenia; LUSC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg12257692 chr3:49977190 RBM6 -0.25 -6.94 -0.36 1.99e-11 Body mass index; LUSC cis rs7953508 0.750 rs7310389 chr12:93976636 A/G cg18151635 chr12:93972918 NA -0.56 -8.0 -0.4 2.04e-14 Pubertal anthropometrics; LUSC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg03060546 chr3:49711283 APEH 0.45 5.97 0.31 6.16e-9 Menarche (age at onset); LUSC cis rs10504073 0.669 rs4493917 chr8:50015846 C/T cg00325661 chr8:49890786 NA 0.62 10.04 0.48 6.47e-21 Blood metabolite ratios; LUSC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs3771570 0.901 rs10190033 chr2:242412358 A/C cg21155796 chr2:242212141 HDLBP 0.5 5.92 0.31 7.84e-9 Prostate cancer; LUSC cis rs477895 1.000 rs477895 chr11:64048912 C/T cg23719950 chr11:63933701 MACROD1 0.58 7.34 0.37 1.6e-12 Mean platelet volume; LUSC trans rs9944275 0.799 rs7163690 chr15:97206581 A/C cg18834029 chr10:103349097 POLL;RP11-529I10.4 -0.52 -5.98 -0.31 5.7e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); LUSC cis rs9325144 0.555 rs6582607 chr12:38717678 T/C cg13010199 chr12:38710504 ALG10B -0.47 -7.17 -0.37 4.99e-12 Morning vs. evening chronotype; LUSC cis rs9300255 0.550 rs10772997 chr12:123719880 C/A cg00376283 chr12:123451042 ABCB9 0.69 9.81 0.47 3.98e-20 Neutrophil percentage of white cells; LUSC cis rs7224314 1.000 rs7224314 chr17:65386214 A/C cg01507342 chr17:65387096 PITPNC1 -0.46 -8.24 -0.41 3.98e-15 Diisocyanate-induced asthma; LUSC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg17264618 chr3:40429014 ENTPD3 0.3 6.46 0.33 3.61e-10 Renal cell carcinoma; LUSC cis rs2078087 0.831 rs10911291 chr1:183233815 G/A cg13843938 chr1:183241246 NMNAT2 0.44 5.89 0.31 9.45e-9 Obesity-related traits; LUSC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg18512352 chr11:47633146 NA -0.48 -9.85 -0.47 2.99e-20 Subjective well-being; LUSC cis rs1577917 0.876 rs12212808 chr6:86533972 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs7336332 0.598 rs76249173 chr13:28010445 A/G cg22138327 chr13:27999177 GTF3A 0.8 10.02 0.48 7.6e-21 Weight; LUSC cis rs694739 0.726 rs516124 chr11:64128423 G/T cg26898376 chr11:64110657 CCDC88B 0.34 6.4 0.33 5.11e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg22963979 chr7:1858916 MAD1L1 -0.51 -7.69 -0.39 1.61e-13 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.526 rs10026625 chr4:120280136 T/C cg09307838 chr4:120376055 NA 0.55 8.13 0.41 8.52e-15 Corneal astigmatism; LUSC cis rs28647808 0.881 rs7042326 chr9:136266636 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC cis rs9902453 0.933 rs1532042 chr17:28504389 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.8 0.39 8.05e-14 Coffee consumption (cups per day); LUSC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -6.06 -0.31 3.7e-9 Personality dimensions; LUSC cis rs2797160 1.000 rs2747714 chr6:126007620 A/G cg05901451 chr6:126070800 HEY2 0.58 8.59 0.43 3.43e-16 Endometrial cancer; LUSC cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs12681287 0.640 rs12549332 chr8:87353392 G/A cg27223183 chr8:87520930 FAM82B -0.53 -7.02 -0.36 1.28e-11 Caudate activity during reward; LUSC cis rs9311676 0.656 rs56198078 chr3:58392224 G/C cg26110898 chr3:58419937 PDHB 0.4 6.48 0.33 3.23e-10 Systemic lupus erythematosus; LUSC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.31 -0.45 1.79e-18 Prostate cancer; LUSC cis rs2219968 0.962 rs13263076 chr8:78970258 T/C cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.93 0.35 2.18e-11 Tonsillectomy; LUSC trans rs11696501 0.688 rs4812955 chr20:44324638 G/C cg03272292 chr12:48577362 C12orf68 0.5 5.96 0.31 6.31e-9 Brain structure; LUSC cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg16482183 chr6:26056742 HIST1H1C 0.47 6.82 0.35 4.29e-11 Height; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg12379764 chr21:47803548 PCNT 0.49 7.12 0.36 6.49e-12 Testicular germ cell tumor; LUSC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.39 -0.33 5.47e-10 Lung cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17976829 chr10:131934431 GLRX3 0.48 7.32 0.37 1.9e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg23711669 chr6:146136114 FBXO30 -0.87 -16.34 -0.67 1.56e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg05623727 chr3:50126028 RBM5 -0.33 -6.3 -0.33 9.52e-10 Body mass index; LUSC cis rs12711979 0.513 rs4849991 chr2:3840545 T/G cg17052675 chr2:3827356 NA -0.37 -6.14 -0.32 2.29e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs72627509 0.904 rs56281640 chr4:57765816 G/A cg26694713 chr4:57773883 REST 0.52 6.29 0.33 1.01e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg08213375 chr14:104286397 PPP1R13B 0.47 8.55 0.42 4.52e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.83 -14.22 -0.61 3.14e-36 Menarche (age at onset); LUSC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg16797656 chr11:68205561 LRP5 -0.39 -7.14 -0.36 5.87e-12 Total body bone mineral density; LUSC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg18512352 chr11:47633146 NA -0.48 -9.73 -0.47 7.33e-20 Subjective well-being; LUSC cis rs765787 0.530 rs2413782 chr15:45538490 A/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs1775715 0.870 rs1775731 chr10:32253512 A/G cg18675610 chr10:32216311 ARHGAP12 0.29 6.0 0.31 5.11e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg21573476 chr21:45109991 RRP1B -0.37 -5.92 -0.31 7.85e-9 Mean corpuscular volume; LUSC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg02187348 chr16:89574699 SPG7 0.5 7.93 0.4 3.27e-14 Multiple myeloma (IgH translocation); LUSC trans rs6952808 0.609 rs6950151 chr7:1953521 T/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.36 0.33 6.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.45 -0.46 6.03e-19 Schizophrenia; LUSC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg13628971 chr7:2884303 GNA12 0.48 6.8 0.35 4.84e-11 Height; LUSC cis rs231513 0.911 rs537165 chr17:41976736 C/T cg26893861 chr17:41843967 DUSP3 -0.51 -6.06 -0.31 3.74e-9 Cognitive function; LUSC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg11247378 chr22:39784982 NA -0.64 -12.82 -0.57 6.95e-31 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.659 rs3809724 chr17:57061238 G/A cg25039879 chr17:56429692 SUPT4H1 0.71 9.29 0.45 2.02e-18 Cognitive test performance; LUSC cis rs6596100 0.538 rs17516673 chr5:132196711 C/T cg02081065 chr5:132209139 LEAP2 -0.62 -5.9 -0.31 9.1e-9 Breast cancer; LUSC cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg23711669 chr6:146136114 FBXO30 0.88 16.24 0.66 4e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg11812906 chr14:75593930 NEK9 -0.63 -10.49 -0.5 2e-22 Height; LUSC cis rs477692 1.000 rs503660 chr10:131418999 A/G cg26102564 chr10:131424627 MGMT 0.37 5.93 0.31 7.52e-9 Response to temozolomide; LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg16606324 chr3:10149918 C3orf24 0.64 8.92 0.44 3.07e-17 Alzheimer's disease; LUSC cis rs9300255 0.568 rs1790102 chr12:123704890 G/A cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs7824557 0.564 rs2572392 chr8:11235605 T/G cg21775007 chr8:11205619 TDH -0.65 -10.3 -0.49 9.02e-22 Retinal vascular caliber; LUSC cis rs2486288 0.656 rs11629859 chr15:45547121 T/G cg04036182 chr15:45458818 NA -0.36 -5.73 -0.3 2.22e-8 Glomerular filtration rate; LUSC cis rs2348418 0.864 rs11049714 chr12:28714095 G/A cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC trans rs7980799 0.591 rs10844614 chr12:33605702 A/C cg26384229 chr12:38710491 ALG10B -0.57 -8.36 -0.42 1.69e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2267681 0.544 rs2361644 chr7:139516316 G/A cg14116596 chr7:139528673 TBXAS1 0.37 6.42 0.33 4.77e-10 Cervical cancer; LUSC trans rs911555 0.755 rs34411783 chr14:103900639 G/A cg17675199 chr6:35436792 RPL10A -0.4 -5.95 -0.31 6.67e-9 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg04369109 chr6:150039330 LATS1 -0.52 -7.41 -0.38 1.06e-12 Lung cancer; LUSC cis rs1997103 1.000 rs2331068 chr7:55408220 G/A cg17469321 chr7:55412551 NA 0.65 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9790314 0.690 rs7614375 chr3:160851331 A/T cg03342759 chr3:160939853 NMD3 -0.41 -6.73 -0.35 7.18e-11 Morning vs. evening chronotype; LUSC cis rs9650657 0.644 rs6601535 chr8:10695652 G/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.25 -0.32 1.28e-9 Neuroticism; LUSC cis rs1322512 1.000 rs2800634 chr6:153010414 G/A cg27316956 chr6:152958899 SYNE1 0.34 5.97 0.31 6.01e-9 Tonometry; LUSC cis rs2898290 0.622 rs1600250 chr8:11345425 A/C cg27411982 chr8:10470053 RP1L1 -0.41 -6.66 -0.34 1.13e-10 Systolic blood pressure; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.0 0.55 7.78e-28 Prudent dietary pattern; LUSC trans rs453301 0.653 rs7016139 chr8:8895470 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.95 -0.31 6.76e-9 Joint mobility (Beighton score); LUSC cis rs68170813 0.599 rs12532849 chr7:106959226 A/C cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.77 -0.3 1.81e-8 Coronary artery disease; LUSC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg01879757 chr17:41196368 BRCA1 -0.45 -6.84 -0.35 3.68e-11 Menopause (age at onset); LUSC cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs11018904 0.768 rs35389990 chr11:89978683 T/C cg26138821 chr11:89956704 CHORDC1 -0.59 -6.71 -0.34 8.28e-11 Intelligence (multi-trait analysis); LUSC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg27211696 chr2:191398769 TMEM194B 0.63 12.18 0.55 1.8e-28 Pulse pressure; LUSC cis rs6599077 1.000 rs9842262 chr3:40095675 T/G cg13683864 chr3:40499215 RPL14 -0.6 -7.66 -0.39 2.06e-13 Sleep-related phenotypes; LUSC cis rs6964587 1.000 rs411 chr7:91557758 C/G cg01689657 chr7:91764605 CYP51A1 -0.34 -6.06 -0.31 3.58e-9 Breast cancer; LUSC cis rs4478858 0.663 rs11591060 chr1:31780012 G/A cg00250761 chr1:31883323 NA -0.35 -8.54 -0.42 4.8e-16 Alcohol dependence; LUSC cis rs4363385 0.693 rs7556517 chr1:152925755 G/T cg07796016 chr1:152779584 LCE1C 0.48 6.91 0.35 2.5e-11 Inflammatory skin disease; LUSC cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg05985134 chr18:33552581 C18orf21 0.51 6.84 0.35 3.76e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11890956 chr21:40555474 PSMG1 1.03 20.49 0.75 5.09e-61 Cognitive function; LUSC cis rs11048434 0.736 rs7301381 chr12:9123932 T/C cg04155231 chr12:9217510 LOC144571 0.3 5.67 0.3 3.11e-8 Sjögren's syndrome; LUSC cis rs983392 0.805 rs2123314 chr11:59966295 C/T cg20284999 chr11:59952153 MS4A6A 0.4 6.93 0.35 2.24e-11 Alzheimer's disease (late onset); LUSC cis rs2303282 0.716 rs2966206 chr16:56441253 G/A cg00500540 chr16:56394104 NA -0.43 -7.33 -0.37 1.74e-12 Breast cancer; LUSC cis rs56283067 0.847 rs10456536 chr6:44692995 G/C cg20913747 chr6:44695427 NA -0.49 -7.97 -0.4 2.54e-14 Total body bone mineral density; LUSC cis rs796364 0.570 rs35733345 chr2:200647533 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.63 -6.57 -0.34 1.96e-10 Schizophrenia; LUSC cis rs9287719 0.967 rs6721514 chr2:10751062 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs12545109 0.800 rs1530217 chr8:57408097 C/T cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.1e-10 Obesity-related traits; LUSC cis rs6722750 0.901 rs6710681 chr2:64413221 A/G cg22352474 chr2:64371530 PELI1 -0.45 -6.77 -0.35 5.71e-11 Neuroticism; LUSC cis rs7267979 0.899 rs6115213 chr20:25550372 G/A cg08601574 chr20:25228251 PYGB 0.39 5.98 0.31 5.71e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg08280861 chr8:58055591 NA -0.58 -6.29 -0.33 9.87e-10 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg07167872 chr1:205819463 PM20D1 0.9 17.74 0.7 4.53e-50 Menarche (age at onset); LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.67 0.6 4.14e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.45 5.9 0.31 8.79e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7584330 0.737 rs13397017 chr2:238361241 G/A cg16989719 chr2:238392110 NA -0.41 -7.18 -0.37 4.43e-12 Prostate cancer; LUSC cis rs79349575 0.687 rs12602179 chr17:47010034 G/T cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.7e-12 Type 2 diabetes; LUSC cis rs4631830 0.832 rs2843554 chr10:51523861 G/T cg16070123 chr10:51489643 NA -0.5 -7.99 -0.4 2.21e-14 Prostate-specific antigen levels; LUSC cis rs708547 0.874 rs1718837 chr4:57871203 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.83 -0.35 3.98e-11 Response to bleomycin (chromatid breaks); LUSC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.38 -0.37 1.25e-12 Electroencephalogram traits; LUSC cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.86 0.4 5.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1048238 0.506 rs848194 chr1:16285342 G/A cg21385522 chr1:16154831 NA -0.56 -8.21 -0.41 5.04e-15 Systolic blood pressure; LUSC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg18825119 chr6:163149453 PACRG;PARK2 -0.35 -6.2 -0.32 1.67e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg00684032 chr4:1343700 KIAA1530 0.36 6.18 0.32 1.91e-9 Obesity-related traits; LUSC cis rs9467773 0.935 rs11752946 chr6:26560364 C/A cg05738196 chr6:26577821 NA 0.78 14.06 0.61 1.32e-35 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg22143856 chr6:28129313 ZNF389 0.42 5.78 0.3 1.73e-8 Parkinson's disease; LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg00106254 chr7:1943704 MAD1L1 -0.42 -6.01 -0.31 4.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg13607699 chr17:42295918 UBTF -0.54 -8.46 -0.42 8.29e-16 Total body bone mineral density; LUSC cis rs6570726 0.935 rs367612 chr6:145828987 A/G cg23711669 chr6:146136114 FBXO30 0.73 12.89 0.58 3.92e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg03806693 chr22:41940476 POLR3H -0.96 -13.64 -0.6 5.69e-34 Vitiligo; LUSC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg02487422 chr3:49467188 NICN1 0.41 5.79 0.3 1.64e-8 Parkinson's disease; LUSC cis rs11051970 0.879 rs2728680 chr12:32583512 T/C cg02745156 chr12:32552066 NA 0.43 7.29 0.37 2.29e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7771547 0.573 rs584418 chr6:36395437 G/A cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg11062466 chr8:58055876 NA 0.42 5.66 0.3 3.32e-8 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.506 rs11057251 chr12:123791227 A/G cg13010344 chr12:123464640 ARL6IP4 0.49 8.01 0.4 1.92e-14 Neutrophil percentage of white cells; LUSC trans rs629535 0.665 rs2433331 chr8:70041943 T/C cg21567404 chr3:27674614 NA 0.97 15.28 0.64 2.54e-40 Dupuytren's disease; LUSC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.11 0.36 7.26e-12 Mean platelet volume; LUSC cis rs6987853 0.787 rs2974300 chr8:42440532 C/T cg09913449 chr8:42400586 C8orf40 0.51 8.82 0.43 6.44e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg03676636 chr4:99064102 C4orf37 0.36 7.84 0.39 6.16e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6539267 0.741 rs7314289 chr12:106686260 A/C cg00173435 chr12:106696525 TCP11L2 0.6 8.68 0.43 1.83e-16 Tourette syndrome; LUSC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg11366901 chr6:160182831 ACAT2 0.93 12.69 0.57 2.24e-30 Age-related macular degeneration (geographic atrophy); LUSC trans rs853679 1.000 rs853676 chr6:28299687 C/T cg06606381 chr12:133084897 FBRSL1 -0.58 -6.32 -0.33 8.28e-10 Depression; LUSC trans rs7726839 0.540 rs72703079 chr5:595173 T/C cg11887960 chr12:57824829 NA 0.54 6.8 0.35 4.89e-11 Obesity-related traits; LUSC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.8 -0.3 1.58e-8 Tonsillectomy; LUSC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg05855489 chr10:104503620 C10orf26 -0.76 -12.89 -0.58 3.99e-31 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg26304593 chr6:42947056 PEX6 -0.49 -7.4 -0.38 1.13e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg07362569 chr17:61921086 SMARCD2 0.37 7.67 0.39 1.94e-13 Prudent dietary pattern; LUSC cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg04586622 chr2:25135609 ADCY3 0.43 9.13 0.45 6.59e-18 Body mass index; LUSC cis rs7220401 0.512 rs71371126 chr17:28002642 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -8.71 -0.43 1.39e-16 Coronary artery disease; LUSC cis rs9290065 0.519 rs956447 chr3:160668917 G/C cg03342759 chr3:160939853 NMD3 -0.43 -6.37 -0.33 6.25e-10 Kawasaki disease; LUSC cis rs2540226 0.935 rs6731450 chr2:39977336 G/C cg23576258 chr2:39999331 THUMPD2 0.34 5.72 0.3 2.35e-8 Personality dimensions; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.72e-10 Intelligence (multi-trait analysis); LUSC cis rs6967385 0.604 rs2883866 chr7:12332245 T/A cg20607287 chr7:12443886 VWDE 0.36 5.67 0.3 3.12e-8 Response to taxane treatment (placlitaxel); LUSC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg19230755 chr7:65878503 NA 0.43 6.06 0.31 3.59e-9 Aortic root size; LUSC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg15839431 chr19:19639596 YJEFN3 0.42 5.73 0.3 2.3e-8 Tonsillectomy; LUSC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.78 0.6 1.66e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12893668 0.703 rs34026011 chr14:104050883 G/A cg08213375 chr14:104286397 PPP1R13B 0.35 5.93 0.31 7.49e-9 Reticulocyte count; LUSC trans rs2262909 0.962 rs11673195 chr19:22313814 T/C cg17074339 chr11:11642133 GALNTL4 0.43 6.64 0.34 1.24e-10 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs11971779 0.715 rs7779390 chr7:139112953 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg25036284 chr2:26402008 FAM59B -0.68 -9.85 -0.47 2.84e-20 Gut microbiome composition (summer); LUSC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg13683864 chr3:40499215 RPL14 -1.14 -21.3 -0.76 3.44e-64 Renal cell carcinoma; LUSC cis rs500891 0.525 rs1170346 chr6:84021751 C/T cg08257003 chr6:84140564 ME1 0.34 7.74 0.39 1.19e-13 Platelet-derived growth factor BB levels; LUSC cis rs9902453 0.967 rs61014003 chr17:28485233 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.52 7.84 0.39 6.01e-14 Coffee consumption (cups per day); LUSC cis rs977987 0.835 rs4888379 chr16:75340231 A/T cg03315344 chr16:75512273 CHST6 0.51 9.86 0.47 2.74e-20 Dupuytren's disease; LUSC trans rs35110281 0.627 rs6518268 chr21:44967448 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.61 10.72 0.51 3.02e-23 Mean corpuscular volume; LUSC trans rs2188420 0.745 rs1636804 chr7:106591791 T/C cg04262465 chr14:101405693 SNORD113-6 -0.39 -5.99 -0.31 5.48e-9 Interferon gamma levels; LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2652834 0.718 rs8034620 chr15:63397155 C/T cg05507819 chr15:63340323 TPM1 0.55 6.98 0.36 1.55e-11 HDL cholesterol; LUSC cis rs6547741 1.000 rs10205364 chr2:27794233 C/T cg12559939 chr2:27858050 GPN1 0.4 6.31 0.33 8.83e-10 Oral cavity cancer; LUSC cis rs722599 0.748 rs55707505 chr14:75362552 T/C cg08847533 chr14:75593920 NEK9 -0.44 -6.25 -0.32 1.26e-9 IgG glycosylation; LUSC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg11663144 chr21:46675770 NA -0.42 -7.26 -0.37 2.72e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs73200209 0.744 rs17498802 chr12:116642212 T/G cg01776926 chr12:116560359 MED13L -0.51 -6.18 -0.32 1.9e-9 Total body bone mineral density; LUSC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg03732007 chr1:2071316 PRKCZ -0.56 -10.12 -0.48 3.51e-21 Height; LUSC cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg06064525 chr11:970664 AP2A2 -0.35 -7.02 -0.36 1.21e-11 Alzheimer's disease (late onset); LUSC trans rs2243480 1.000 rs13247184 chr7:65358928 A/G cg10756647 chr7:56101905 PSPH 0.88 8.45 0.42 8.8e-16 Diabetic kidney disease; LUSC cis rs1832871 1.000 rs705930 chr6:158711855 T/C cg07165851 chr6:158734300 TULP4 0.37 6.35 0.33 6.94e-10 Height; LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.18 -0.32 1.87e-9 Bipolar disorder and schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16204216 chr11:3818895 PGAP2;NUP98 -0.41 -6.16 -0.32 2.12e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11711311 1.000 rs12637067 chr3:113527606 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.84 -0.3 1.22e-8 IgG glycosylation; LUSC cis rs6942756 0.668 rs644723 chr7:129107881 C/T cg02491457 chr7:128862824 NA -0.4 -5.72 -0.3 2.35e-8 White matter hyperintensity burden; LUSC cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9287719 0.967 rs10191883 chr2:10744136 A/G cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs7267979 1.000 rs4815411 chr20:25350223 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -19.85 -0.74 1.77e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs17102423 0.896 rs11158577 chr14:65596490 A/G cg11161011 chr14:65562177 MAX -0.61 -9.25 -0.45 2.78e-18 Obesity-related traits; LUSC cis rs17102423 0.661 rs11627540 chr14:65614892 C/T cg11161011 chr14:65562177 MAX -0.69 -9.18 -0.45 4.48e-18 Obesity-related traits; LUSC cis rs2708977 0.637 rs583705 chr2:97068754 C/T cg01950434 chr2:97203154 ARID5A -0.45 -6.2 -0.32 1.71e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.88 0.35 2.93e-11 Schizophrenia; LUSC cis rs7577851 1.000 rs6757825 chr2:69741801 C/T cg10773587 chr2:69614142 GFPT1 0.49 5.67 0.3 3.04e-8 Parkinson's disease (age of onset); LUSC cis rs68170813 0.652 rs116894096 chr7:107178477 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg21280719 chr6:42927975 GNMT -0.31 -7.84 -0.39 6.14e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12594515 1.000 rs11855562 chr15:45995659 C/T cg06207120 chr15:45996521 NA 0.39 5.86 0.31 1.11e-8 Waist circumference;Weight; LUSC cis rs7605827 0.897 rs2380650 chr2:15533689 T/C cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC trans rs9409565 0.826 rs4744345 chr9:97207669 G/A cg05679027 chr9:99775184 HIATL2 -0.49 -7.0 -0.36 1.43e-11 Colorectal cancer (alcohol consumption interaction); LUSC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs8062405 1.000 rs4788099 chr16:28855727 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07667813 chr19:7985168 SNAPC2 -0.33 -6.16 -0.32 2.04e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs17253792 0.822 rs112418863 chr14:56114079 G/A cg01858014 chr14:56050164 KTN1 -0.8 -6.58 -0.34 1.79e-10 Putamen volume; LUSC cis rs4700695 0.719 rs153390 chr5:65431087 G/C cg21114390 chr5:65439923 SFRS12 -0.62 -8.57 -0.42 3.9e-16 Facial morphology (factor 19); LUSC cis rs6076065 0.723 rs6083095 chr20:23354090 C/T cg11657817 chr20:23433608 CST11 0.42 7.92 0.4 3.62e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg21535247 chr6:8435926 SLC35B3 0.56 8.49 0.42 6.76e-16 Motion sickness; LUSC cis rs9359856 0.510 rs2768940 chr6:90436319 A/G cg13799429 chr6:90582589 CASP8AP2 -0.9 -10.8 -0.51 1.58e-23 Bipolar disorder; LUSC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg07424592 chr7:64974309 NA 0.66 5.8 0.3 1.55e-8 Diabetic kidney disease; LUSC cis rs12618769 0.652 rs7595120 chr2:99231805 C/G cg10123293 chr2:99228465 UNC50 0.46 7.52 0.38 5.16e-13 Bipolar disorder; LUSC cis rs6599077 0.950 rs4676563 chr3:40105092 G/C cg13683864 chr3:40499215 RPL14 -0.61 -7.6 -0.38 3.09e-13 Sleep-related phenotypes; LUSC cis rs936229 0.690 rs2472299 chr15:75033400 C/T cg10253484 chr15:75165896 SCAMP2 0.5 6.91 0.35 2.47e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg05084668 chr3:125655381 ALG1L -0.49 -6.86 -0.35 3.26e-11 Blood pressure (smoking interaction); LUSC trans rs11098499 0.863 rs13136462 chr4:120543173 C/T cg25214090 chr10:38739885 LOC399744 0.51 7.54 0.38 4.35e-13 Corneal astigmatism; LUSC trans rs877282 0.853 rs7092805 chr10:756246 G/A cg22713356 chr15:30763199 NA 1.0 13.06 0.58 8.86e-32 Uric acid levels; LUSC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg17971929 chr21:40555470 PSMG1 -0.5 -7.35 -0.37 1.5e-12 Menarche (age at onset); LUSC cis rs79349575 0.783 rs62075820 chr17:46983171 G/C cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11644478 chr21:40555479 PSMG1 0.72 12.31 0.56 5.67e-29 Cognitive function; LUSC cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.53 0.38 4.76e-13 Colorectal cancer; LUSC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg07959070 chr22:50026188 C22orf34 -0.36 -7.39 -0.37 1.22e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9549260 0.617 rs9549266 chr13:41278409 C/G cg21288729 chr13:41239152 FOXO1 0.59 6.57 0.34 1.89e-10 Red blood cell count; LUSC cis rs11642862 0.901 rs112190455 chr16:30971437 C/T cg02466173 chr16:30829666 NA -0.63 -6.45 -0.33 3.9e-10 Tonsillectomy; LUSC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg12927641 chr6:109611667 NA -0.34 -5.82 -0.3 1.38e-8 Reticulocyte fraction of red cells; LUSC cis rs10876993 0.855 rs1678520 chr12:58049319 C/G cg18357645 chr12:58087776 OS9 0.52 7.77 0.39 9.44e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02018176 chr4:1364513 KIAA1530 0.71 13.59 0.6 8.57e-34 Longevity; LUSC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg13057898 chr1:3703894 LRRC47 0.5 8.97 0.44 2.23e-17 Red cell distribution width; LUSC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs259282 0.813 rs259250 chr19:33149216 T/C cg22980127 chr19:33182716 NUDT19 -0.43 -6.28 -0.32 1.06e-9 Schizophrenia; LUSC cis rs9329289 1.000 rs9329289 chr10:2542389 A/G cg15501526 chr10:2543763 NA 0.67 12.8 0.57 8.76e-31 Age-related hearing impairment; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg05552183 chr6:42928497 GNMT 0.49 8.17 0.41 6.42e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1190552 0.846 rs3742437 chr14:102965047 G/A cg18135206 chr14:102964638 TECPR2 0.48 5.89 0.31 9.54e-9 Blood protein levels; LUSC cis rs11958404 0.932 rs76228149 chr5:157434486 G/A cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.55 0.34 2.17e-10 Mean platelet volume; LUSC cis rs7100689 0.646 rs1934693 chr10:82125650 T/C cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.89 0.35 2.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs73206853 0.686 rs73194021 chr12:111131893 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 6.73 0.35 7.61e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6690583 0.573 rs7547317 chr1:85456961 T/G cg22153463 chr1:85462885 MCOLN2 0.62 5.7 0.3 2.68e-8 Serum sulfate level; LUSC cis rs4954585 0.683 rs11678502 chr2:136994454 C/T cg05194412 chr2:137003533 NA 0.38 6.99 0.36 1.49e-11 Colorectal cancer; LUSC cis rs826838 1.000 rs11168367 chr12:38913397 T/G cg26384229 chr12:38710491 ALG10B 0.93 17.43 0.69 7.74e-49 Heart rate; LUSC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg20684491 chr1:25596433 NA 0.38 5.99 0.31 5.34e-9 Erythrocyte sedimentation rate; LUSC cis rs4713675 0.565 rs2274458 chr6:33679596 A/C cg14003231 chr6:33640908 ITPR3 0.29 5.68 0.3 2.93e-8 Plateletcrit; LUSC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC trans rs7980799 0.618 rs1482983 chr12:33690326 A/C cg26384229 chr12:38710491 ALG10B 0.57 8.23 0.41 4.3e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1559088 1.000 rs1974783 chr19:33551507 C/G cg17764715 chr19:33622953 WDR88 0.58 7.86 0.4 5.25e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7954584 0.635 rs7313252 chr12:122347600 G/A cg01765077 chr12:122356316 WDR66 0.51 7.26 0.37 2.81e-12 Mean corpuscular volume; LUSC cis rs597583 0.806 rs1941390 chr11:117396991 G/A cg27161313 chr11:117392002 DSCAML1 -0.43 -7.19 -0.37 4.33e-12 Putamen volume; LUSC trans rs11098499 0.866 rs72676074 chr4:120359841 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.09e-9 Corneal astigmatism; LUSC trans rs75804782 0.580 rs72987332 chr2:239362529 G/T cg01134436 chr17:81009848 B3GNTL1 0.64 6.16 0.32 2.14e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg08330031 chr10:104623503 C10orf32 0.31 5.66 0.3 3.32e-8 Arsenic metabolism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27535044 chr8:82633568 ZFAND1 -0.51 -6.3 -0.33 9.21e-10 Bipolar disorder and schizophrenia; LUSC cis rs13191362 0.507 rs13210000 chr6:163176944 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.52 0.46 3.64e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs977987 0.806 rs4888411 chr16:75443183 T/A cg03315344 chr16:75512273 CHST6 0.48 8.98 0.44 2.08e-17 Dupuytren's disease; LUSC trans rs853679 0.517 rs9368551 chr6:28061792 A/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.31e-9 Depression; LUSC cis rs2486288 0.656 rs12915314 chr15:45551491 C/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.89 -0.4 4.34e-14 Glomerular filtration rate; LUSC cis rs76878669 0.538 rs4930360 chr11:66143247 T/A cg18002602 chr11:66138449 SLC29A2 0.47 8.38 0.42 1.44e-15 Educational attainment (years of education); LUSC cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs17685 0.753 rs10262501 chr7:75668172 G/A cg19862616 chr7:65841803 NCRNA00174 -1.09 -19.0 -0.72 4.48e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2839186 0.872 rs13046834 chr21:47701485 T/C cg13126279 chr21:47581558 C21orf56 -0.42 -6.17 -0.32 1.93e-9 Testicular germ cell tumor; LUSC cis rs7945705 0.875 rs4929914 chr11:8824388 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.31 -6.15 -0.32 2.17e-9 Hemoglobin concentration; LUSC cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg18132916 chr6:79620363 NA -0.37 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg27094323 chr7:1216898 NA -0.43 -7.2 -0.37 3.97e-12 Longevity;Endometriosis; LUSC cis rs11955175 1.000 rs11956741 chr5:40677576 G/C cg05478818 chr5:40835740 RPL37 0.7 5.77 0.3 1.81e-8 Bipolar disorder and schizophrenia; LUSC cis rs6692729 0.966 rs6674701 chr1:227007182 A/G cg10327440 chr1:227177885 CDC42BPA 0.46 6.6 0.34 1.64e-10 Electrodermal activity; LUSC cis rs2404602 0.679 rs12908421 chr15:76881794 T/G cg23625390 chr15:77176239 SCAPER 0.46 7.03 0.36 1.15e-11 Blood metabolite levels; LUSC cis rs6545883 0.859 rs7561672 chr2:61519094 G/A cg15711740 chr2:61764176 XPO1 0.44 6.78 0.35 5.44e-11 Tuberculosis; LUSC cis rs9309473 0.500 rs12472502 chr2:73859184 C/T cg20560298 chr2:73613845 ALMS1 0.46 6.93 0.35 2.13e-11 Metabolite levels; LUSC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg05340658 chr4:99064831 C4orf37 0.68 11.4 0.53 1.23e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23375783 chr17:73008576 ICT1 -0.5 -6.55 -0.34 2.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg13770153 chr20:60521292 NA -0.61 -8.28 -0.41 3.08e-15 Body mass index; LUSC cis rs59698941 0.943 rs72799496 chr5:132290911 T/C cg02081065 chr5:132209139 LEAP2 -0.66 -6.63 -0.34 1.33e-10 Apolipoprotein A-IV levels; LUSC cis rs10782582 0.609 rs5745469 chr1:76347394 G/A cg03433033 chr1:76189801 ACADM -0.39 -5.7 -0.3 2.6e-8 Daytime sleep phenotypes; LUSC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg16989086 chr20:62203971 PRIC285 0.45 6.34 0.33 7.32e-10 Glioblastoma; LUSC cis rs12760731 0.623 rs1985761 chr1:178438645 A/G cg00404053 chr1:178313656 RASAL2 0.47 5.79 0.3 1.6e-8 Obesity-related traits; LUSC cis rs1729951 0.575 rs361243 chr3:136697786 C/T cg21827317 chr3:136751795 NA 0.38 6.9 0.35 2.63e-11 Neuroticism; LUSC cis rs6722750 0.716 rs1554877 chr2:64418977 A/G cg22352474 chr2:64371530 PELI1 -0.54 -8.2 -0.41 5.29e-15 Neuroticism; LUSC trans rs853679 0.599 rs149943 chr6:28002388 G/A cg06606381 chr12:133084897 FBRSL1 -0.65 -7.15 -0.36 5.51e-12 Depression; LUSC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg06808227 chr14:105710500 BRF1 -0.68 -10.69 -0.5 4e-23 Mean platelet volume;Platelet distribution width; LUSC cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.27 0.41 3.21e-15 Menarche (age at onset); LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg06873352 chr17:61820015 STRADA 0.71 12.65 0.57 3.17e-30 Prudent dietary pattern; LUSC cis rs12618769 0.597 rs72819965 chr2:99023719 G/C cg10123293 chr2:99228465 UNC50 0.48 8.1 0.41 1.01e-14 Bipolar disorder; LUSC cis rs2762353 0.603 rs4145221 chr6:25763192 A/G cg12310025 chr6:25882481 NA 0.36 6.1 0.32 3.01e-9 Blood metabolite levels; LUSC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.97 -0.55 1.04e-27 Extrinsic epigenetic age acceleration; LUSC cis rs12973672 0.904 rs10424619 chr19:35768237 A/T cg12095397 chr19:35769544 USF2 0.43 6.61 0.34 1.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg18825119 chr6:163149453 PACRG;PARK2 -0.36 -6.33 -0.33 7.75e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.774 rs2247571 chr6:146219533 T/A cg05347473 chr6:146136440 FBXO30 0.45 7.44 0.38 8.78e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03870842 chr4:123843873 NUDT6;SPATA5 -0.45 -6.16 -0.32 2.05e-9 Hepatitis; LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg22963979 chr7:1858916 MAD1L1 -0.55 -8.18 -0.41 6.08e-15 Bipolar disorder and schizophrenia; LUSC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg05535760 chr7:792225 HEATR2 0.95 9.78 0.47 5.07e-20 Cerebrospinal P-tau181p levels; LUSC cis rs7927592 0.913 rs3758643 chr11:68367193 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.71 -0.3 2.52e-8 Total body bone mineral density; LUSC cis rs2204008 0.521 rs7311188 chr12:38542813 C/G cg26384229 chr12:38710491 ALG10B -0.54 -8.2 -0.41 5.33e-15 Bladder cancer; LUSC cis rs11711311 1.000 rs7645473 chr3:113516187 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.64 0.34 1.3e-10 IgG glycosylation; LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg18404041 chr3:52824283 ITIH1 -0.56 -10.63 -0.5 6.41e-23 Bipolar disorder; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg11905131 chr22:24372483 LOC391322 -0.62 -10.61 -0.5 7.4e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg11062466 chr8:58055876 NA 0.71 8.73 0.43 1.27e-16 Developmental language disorder (linguistic errors); LUSC cis rs614226 1.000 rs591992 chr12:121019323 T/C cg01236616 chr12:121019343 POP5 1.31 21.44 0.76 9.26e-65 Type 1 diabetes nephropathy; LUSC cis rs8114671 0.967 rs2069948 chr20:33762489 C/T cg07148914 chr20:33460835 GGT7 0.47 6.93 0.35 2.22e-11 Height; LUSC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg21518248 chr2:162101506 NA 0.46 6.96 0.36 1.81e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs2677744 0.534 rs6496739 chr15:91494430 C/T cg23684204 chr15:91497937 RCCD1 0.57 7.95 0.4 2.87e-14 Attention deficit hyperactivity disorder; LUSC cis rs6906287 0.609 rs13191610 chr6:118945317 G/A cg21191810 chr6:118973309 C6orf204 0.32 5.9 0.31 9.06e-9 Electrocardiographic conduction measures; LUSC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg17724175 chr1:150552817 MCL1 0.36 6.48 0.33 3.39e-10 Blood protein levels; LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs2562456 0.833 rs62107547 chr19:21524047 A/C cg00806126 chr19:22604979 ZNF98 -0.43 -6.19 -0.32 1.78e-9 Pain; LUSC cis rs12893668 0.616 rs58033365 chr14:104030901 T/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -6.36 -0.33 6.76e-10 Reticulocyte count; LUSC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg13918804 chr1:2043761 PRKCZ 0.27 5.66 0.3 3.34e-8 Height; LUSC cis rs4417855 0.665 rs9867557 chr3:187410568 G/A cg19198148 chr3:187451818 BCL6 0.57 10.26 0.49 1.2e-21 Granulocyte percentage of myeloid white cells; LUSC cis rs7647973 1.000 rs62259947 chr3:49439924 T/C cg07636037 chr3:49044803 WDR6 -0.67 -8.65 -0.43 2.22e-16 Menarche (age at onset); LUSC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg01368799 chr11:117014884 PAFAH1B2 0.56 8.46 0.42 8.5e-16 Blood protein levels; LUSC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg06634786 chr22:41940651 POLR3H -0.49 -5.79 -0.3 1.6e-8 Vitiligo; LUSC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg13647721 chr17:30228624 UTP6 0.6 6.13 0.32 2.53e-9 Hip circumference adjusted for BMI; LUSC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg08470875 chr2:26401718 FAM59B -0.67 -8.96 -0.44 2.32e-17 Gut microbiome composition (summer); LUSC cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs887829 0.570 rs10445704 chr2:234600274 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.3 -0.33 9.47e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg06008330 chr7:65541103 ASL -0.4 -6.22 -0.32 1.52e-9 Aortic root size; LUSC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg11366901 chr6:160182831 ACAT2 0.93 13.08 0.58 7.49e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs6138458 1.000 rs227624 chr20:24911562 T/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.94 -0.36 2.02e-11 Blood protein levels; LUSC cis rs7940866 0.774 rs7480903 chr11:130832276 A/G cg12179176 chr11:130786555 SNX19 0.62 9.3 0.45 1.89e-18 Schizophrenia; LUSC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg00310523 chr12:86230176 RASSF9 0.53 9.74 0.47 6.71e-20 Major depressive disorder; LUSC cis rs77633900 0.772 rs2469554 chr15:76642700 G/C cg21673338 chr15:77095150 SCAPER -0.69 -5.93 -0.31 7.56e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg11211951 chr8:145729740 GPT 0.57 11.3 0.53 2.65e-25 Age at first birth; LUSC cis rs1949733 0.655 rs2631736 chr4:8478421 C/G cg11789530 chr4:8429930 ACOX3 -0.57 -8.74 -0.43 1.12e-16 Response to antineoplastic agents; LUSC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg11764359 chr7:65958608 NA -0.7 -10.67 -0.5 4.75e-23 Aortic root size; LUSC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg18357526 chr6:26021779 HIST1H4A 0.44 6.57 0.34 1.93e-10 Intelligence (multi-trait analysis); LUSC cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg15605315 chr1:45957053 TESK2 -0.41 -6.58 -0.34 1.81e-10 High light scatter reticulocyte count; LUSC cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg22709100 chr7:91322751 NA 0.39 5.77 0.3 1.8e-8 Breast cancer; LUSC cis rs7267979 0.966 rs2387882 chr20:25378802 C/T cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs62064224 0.658 rs62065460 chr17:30715007 A/G cg25809561 chr17:30822961 MYO1D 0.55 9.62 0.47 1.68e-19 Schizophrenia; LUSC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg22535103 chr8:58192502 C8orf71 -0.73 -7.33 -0.37 1.77e-12 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.917 rs2197651 chr6:86495442 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -9.04 -0.44 1.27e-17 Response to antipsychotic treatment; LUSC cis rs2677744 0.626 rs11207 chr15:91497239 C/T cg23684204 chr15:91497937 RCCD1 0.57 7.86 0.39 5.47e-14 Attention deficit hyperactivity disorder; LUSC cis rs734999 0.588 rs2764841 chr1:2529360 G/A cg18932078 chr1:2524107 MMEL1 -0.29 -6.44 -0.33 4.15e-10 Ulcerative colitis; LUSC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 13.25 0.59 1.67e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg01879757 chr17:41196368 BRCA1 -0.45 -6.84 -0.35 3.68e-11 Menopause (age at onset); LUSC cis rs11112613 0.713 rs12316204 chr12:105944244 G/A cg03607813 chr12:105948248 NA 0.79 11.52 0.53 4.27e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg06022373 chr22:39101656 GTPBP1 0.84 13.96 0.61 3.35e-35 Menopause (age at onset); LUSC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg15335139 chr3:50242325 SLC38A3 -0.27 -5.97 -0.31 5.96e-9 Body mass index; LUSC cis rs7618501 1.000 rs11130219 chr3:49752427 C/T cg07274523 chr3:49395745 GPX1 0.35 5.65 0.3 3.47e-8 Intelligence (multi-trait analysis); LUSC cis rs1050846 0.603 rs1050847 chr16:87443734 A/G cg27585878 chr16:87386489 FBXO31 0.37 6.14 0.32 2.29e-9 Neuroticism; LUSC cis rs7568458 0.905 rs10187424 chr2:85794297 T/C cg23752985 chr2:85803571 VAMP8 0.36 7.83 0.39 6.48e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10911232 0.507 rs5022057 chr1:182997761 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs7119 0.667 rs2867312 chr15:77902293 A/G cg27398640 chr15:77910606 LINGO1 -0.36 -8.67 -0.43 1.91e-16 Type 2 diabetes; LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg07806771 chr7:64541737 NA 0.47 6.68 0.34 9.93e-11 Calcium levels; LUSC cis rs1008375 0.932 rs11934968 chr4:17667766 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.31 0.33 8.84e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg23395165 chr19:4483111 HDGF2 -0.4 -6.32 -0.33 8.5e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26943378 chr22:50689804 HDAC10 -0.46 -7.07 -0.36 9.34e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4332037 0.664 rs73046334 chr7:1887037 T/C cg25206134 chr2:45395956 NA 0.51 5.98 0.31 5.87e-9 Bipolar disorder; LUSC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs5769707 0.967 rs8141807 chr22:50043738 C/G cg08680598 chr22:49984980 NA -0.34 -6.25 -0.32 1.26e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs977987 0.836 rs17685540 chr16:75323840 T/C cg04384234 chr16:75411784 CFDP1 -0.38 -6.0 -0.31 5.04e-9 Dupuytren's disease; LUSC cis rs28595532 0.748 rs55949457 chr4:119336174 A/G cg21605333 chr4:119757512 SEC24D 0.97 8.07 0.4 1.26e-14 Cannabis dependence symptom count; LUSC cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.35 -5.83 -0.3 1.34e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg27284194 chr4:1044797 NA 0.35 5.7 0.3 2.58e-8 Obesity-related traits; LUSC cis rs7824557 0.564 rs7821459 chr8:11236681 T/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.9 -0.31 8.72e-9 Retinal vascular caliber; LUSC cis rs4664308 0.694 rs4665140 chr2:160890710 T/A cg03641300 chr2:160917029 PLA2R1 -0.48 -8.0 -0.4 2.13e-14 Idiopathic membranous nephropathy; LUSC trans rs1325195 0.770 rs965401 chr1:179133221 T/A cg11624085 chr17:8464688 MYH10 0.42 6.73 0.35 7.5e-11 IgE grass sensitization; LUSC cis rs7914558 0.902 rs7092200 chr10:104844872 T/C cg05855489 chr10:104503620 C10orf26 0.55 8.35 0.42 1.82e-15 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs28374715 0.562 rs8036686 chr15:41550333 C/T cg18705301 chr15:41695430 NDUFAF1 -0.69 -12.32 -0.56 5.45e-29 Ulcerative colitis; LUSC cis rs3126085 0.935 rs2338430 chr1:152214420 C/T cg26876637 chr1:152193138 HRNR -0.46 -6.44 -0.33 4.17e-10 Atopic dermatitis; LUSC cis rs9393777 0.778 rs35526527 chr6:27042287 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.45 -5.65 -0.3 3.52e-8 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.34 -0.37 1.61e-12 Menopause (age at onset); LUSC cis rs6502050 0.842 rs6502053 chr17:80066714 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.42e-8 Life satisfaction; LUSC cis rs10191773 0.589 rs72833410 chr2:113054119 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.83 9.32 0.45 1.66e-18 Yeast infection; LUSC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg11245181 chr6:149772854 ZC3H12D 0.3 6.52 0.34 2.63e-10 Dupuytren's disease; LUSC cis rs11155671 0.530 rs9383577 chr6:150207195 C/T cg04369109 chr6:150039330 LATS1 -0.4 -5.78 -0.3 1.67e-8 Testicular germ cell tumor; LUSC cis rs11169552 0.510 rs12231317 chr12:51041005 G/A cg12884762 chr12:50931848 DIP2B -0.31 -5.67 -0.3 3.15e-8 Colorectal cancer; LUSC trans rs9944715 0.954 rs4890629 chr18:43797564 A/G cg01718231 chr17:29326311 RNF135 -0.48 -6.81 -0.35 4.66e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC trans rs61931739 0.890 rs1197560 chr12:34121447 G/C cg13010199 chr12:38710504 ALG10B 0.44 6.95 0.36 1.9e-11 Morning vs. evening chronotype; LUSC cis rs34172651 0.837 rs12596793 chr16:24823667 C/G cg00339695 chr16:24857497 SLC5A11 0.35 6.24 0.32 1.34e-9 Intelligence (multi-trait analysis); LUSC cis rs2303759 0.507 rs35042238 chr19:49872941 C/T cg22307029 chr19:49891270 CCDC155 0.6 6.12 0.32 2.69e-9 Multiple sclerosis; LUSC cis rs4737010 0.536 rs6474365 chr8:41662940 G/T cg08923054 chr8:41654455 ANK1 0.37 6.48 0.33 3.22e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs6977660 0.619 rs12534026 chr7:19788687 T/C cg07541023 chr7:19748670 TWISTNB 0.59 6.73 0.35 7.39e-11 Thyroid stimulating hormone; LUSC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg05639522 chr1:247681581 NA -0.41 -5.65 -0.3 3.45e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs3008870 1.000 rs3008854 chr1:67385951 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.08 0.64 1.48e-39 Lymphocyte percentage of white cells; LUSC cis rs17621444 0.505 rs4237514 chr10:121811325 C/G cg02041677 chr10:121771263 NA -0.33 -6.37 -0.33 6.1e-10 IgG glycosylation; LUSC cis rs7385804 0.761 rs507392 chr7:100319936 G/A cg16850897 chr7:100343110 ZAN 0.36 5.83 0.3 1.3e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg20243544 chr17:37824526 PNMT 0.42 6.48 0.33 3.27e-10 Self-reported allergy; LUSC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg20243544 chr17:37824526 PNMT 0.53 7.46 0.38 7.66e-13 Glomerular filtration rate (creatinine); LUSC cis rs9399135 0.935 rs11760000 chr6:135370496 G/A cg24558204 chr6:135376177 HBS1L 0.58 9.03 0.44 1.38e-17 Red blood cell count; LUSC cis rs849898 1 rs849898 chr1:228153917 A/G cg02753203 chr1:228287806 NA -0.88 -16.23 -0.66 4.53e-44 Parkinson's disease; LUSC cis rs9807841 0.617 rs2229383 chr19:10794630 G/T cg17710535 chr19:10819994 QTRT1 0.42 6.95 0.36 1.97e-11 Inflammatory skin disease; LUSC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg15595755 chr5:1867978 NA 0.45 8.46 0.42 8.21e-16 Cardiovascular disease risk factors; LUSC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.35 -0.33 7.13e-10 Primary sclerosing cholangitis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg19638132 chr11:59521665 STX3 -0.45 -6.44 -0.33 4.22e-10 Hepatitis; LUSC cis rs778371 0.871 rs2675954 chr2:233750627 C/G cg08000102 chr2:233561755 GIGYF2 -0.74 -11.06 -0.52 2e-24 Schizophrenia; LUSC cis rs1808579 1.000 rs11663558 chr18:21133937 G/A cg14672496 chr18:21087552 C18orf8 0.34 5.66 0.3 3.24e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs3126085 0.935 rs12746239 chr1:152246726 G/A cg26876637 chr1:152193138 HRNR -0.44 -5.91 -0.31 8.24e-9 Atopic dermatitis; LUSC cis rs865483 0.929 rs9906140 chr17:35857151 A/G cg06716730 chr17:35851459 DUSP14 -0.28 -6.36 -0.33 6.71e-10 Monocyte count; LUSC cis rs36093844 0.800 rs75605851 chr11:85580031 T/G cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs478304 0.651 rs11600918 chr11:65511965 A/G cg05805236 chr11:65401703 PCNXL3 -0.56 -9.2 -0.45 3.92e-18 Acne (severe); LUSC cis rs977987 0.872 rs4243111 chr16:75320827 C/T cg03315344 chr16:75512273 CHST6 0.49 9.18 0.45 4.59e-18 Dupuytren's disease; LUSC cis rs3790645 1.000 rs392814 chr1:26892009 T/C cg17456097 chr1:26900765 RPS6KA1 0.43 6.18 0.32 1.84e-9 Glucose homeostasis traits; LUSC cis rs1322512 1.000 rs2758785 chr6:153010878 C/T cg27316956 chr6:152958899 SYNE1 0.35 6.04 0.31 4.21e-9 Tonometry; LUSC cis rs9479482 1.000 rs9479481 chr6:150357944 A/G cg00432049 chr6:150390894 ULBP3 -0.27 -5.68 -0.3 2.86e-8 Alopecia areata; LUSC cis rs11785400 0.928 rs2280878 chr8:143722366 G/A cg24634471 chr8:143751801 JRK 0.6 8.92 0.44 3.02e-17 Schizophrenia; LUSC cis rs9473147 0.543 rs9473119 chr6:47450618 G/A cg12968598 chr6:47444699 CD2AP 0.53 8.18 0.41 6.12e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs11608355 0.545 rs6606723 chr12:109905044 C/G cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs9814567 1.000 rs9829092 chr3:134229866 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -13.95 -0.61 3.51e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg00701064 chr4:6280414 WFS1 0.62 15.75 0.65 3.37e-42 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg00376283 chr12:123451042 ABCB9 0.76 11.74 0.54 7.12e-27 Platelet count; LUSC trans rs7773004 0.601 rs13210340 chr6:26326314 G/C cg06606381 chr12:133084897 FBRSL1 -0.77 -6.79 -0.35 5.27e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.57 -0.34 1.92e-10 Lung cancer; LUSC cis rs4805272 0.512 rs4805279 chr19:29336966 A/G cg12756686 chr19:29218302 NA 0.53 6.15 0.32 2.2e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2777491 0.874 rs7161772 chr15:41611066 A/T cg18705301 chr15:41695430 NDUFAF1 -0.76 -13.71 -0.6 3e-34 Ulcerative colitis; LUSC cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs4423214 0.535 rs1540129 chr11:71129523 C/G cg05163923 chr11:71159392 DHCR7 0.51 6.9 0.35 2.65e-11 Vitamin D levels; LUSC cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.37 0.37 1.35e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04297576 chr16:85588660 NA -0.44 -6.74 -0.35 6.83e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4805272 0.512 rs8105613 chr19:29339151 C/T cg12756686 chr19:29218302 NA 0.57 6.49 0.33 3.05e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg03388025 chr16:89894329 SPIRE2 0.33 6.64 0.34 1.25e-10 Vitiligo; LUSC cis rs9875589 0.509 rs9824910 chr3:14040136 C/T cg19554555 chr3:13937349 NA -0.39 -5.84 -0.3 1.25e-8 Ovarian reserve; LUSC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg15534755 chr11:117069859 TAGLN 0.35 6.14 0.32 2.33e-9 Blood protein levels; LUSC cis rs9790314 1.000 rs7653233 chr3:160992033 G/A cg03342759 chr3:160939853 NMD3 -0.52 -8.82 -0.43 6.4e-17 Morning vs. evening chronotype; LUSC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg18357526 chr6:26021779 HIST1H4A 0.4 5.97 0.31 6.22e-9 Intelligence (multi-trait analysis); LUSC cis rs17095355 1.000 rs12263915 chr10:111744664 G/C cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.48 -0.38 6.7e-13 Biliary atresia; LUSC trans rs61931739 0.500 rs12809868 chr12:34464905 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.77 0.51 1.98e-23 Morning vs. evening chronotype; LUSC trans rs2228479 0.681 rs7199685 chr16:89959805 G/C cg24644049 chr4:85504048 CDS1 0.61 6.36 0.33 6.61e-10 Skin colour saturation; LUSC cis rs4363385 0.510 rs10494282 chr1:152923762 G/C cg25856811 chr1:152973957 SPRR3 -0.38 -6.12 -0.32 2.6e-9 Inflammatory skin disease; LUSC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg00990874 chr7:1149470 C7orf50 -0.45 -6.35 -0.33 6.98e-10 Bronchopulmonary dysplasia; LUSC cis rs500891 0.533 rs4706178 chr6:84184472 A/G cg08257003 chr6:84140564 ME1 0.33 8.04 0.4 1.54e-14 Platelet-derived growth factor BB levels; LUSC cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.25 0.56 9.35e-29 Motion sickness; LUSC trans rs8073060 0.544 rs7211724 chr17:33993414 C/G cg19694781 chr19:47549865 TMEM160 -1.16 -18.75 -0.72 4.22e-54 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs12410462 0.581 rs35141785 chr1:227553496 G/C cg10327440 chr1:227177885 CDC42BPA -0.62 -6.11 -0.32 2.79e-9 Major depressive disorder; LUSC cis rs9902453 0.838 rs8064689 chr17:28217053 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.39 0.46 9.94e-19 Coffee consumption (cups per day); LUSC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4654899 0.733 rs10799678 chr1:21322785 C/T cg01072550 chr1:21505969 NA -0.53 -8.18 -0.41 6.01e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7772486 0.875 rs2492855 chr6:146296926 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.43 0.65 6.19e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs6951245 1.000 rs77702926 chr7:1088838 G/A cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg24296786 chr1:45957014 TESK2 0.54 8.34 0.42 1.92e-15 High light scatter reticulocyte count; LUSC cis rs317689 0.684 rs315125 chr12:69758884 C/T cg20891283 chr12:69753455 YEATS4 0.61 8.22 0.41 4.65e-15 Response to diuretic therapy; LUSC cis rs1348850 0.574 rs4893834 chr2:178442288 C/T cg27490568 chr2:178487706 NA -0.38 -5.76 -0.3 1.96e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg20203395 chr5:56204925 C5orf35 -0.54 -7.69 -0.39 1.65e-13 Coronary artery disease; LUSC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg12432903 chr7:1882776 MAD1L1 -0.37 -5.89 -0.31 9.43e-9 Bipolar disorder and schizophrenia; LUSC trans rs853679 0.607 rs34166054 chr6:28065801 T/C cg01620082 chr3:125678407 NA -0.87 -7.55 -0.38 4.28e-13 Depression; LUSC trans rs6076960 0.684 rs3909086 chr20:6251639 A/G cg21095983 chr6:86352623 SYNCRIP 0.5 7.63 0.39 2.44e-13 Smooth-surface caries; LUSC cis rs2115630 0.691 rs61322921 chr15:85163638 T/C cg17173187 chr15:85201210 NMB -0.32 -6.56 -0.34 2e-10 P wave terminal force; LUSC cis rs1568889 0.730 rs6484350 chr11:28113658 G/A cg06544937 chr11:28130018 METT5D1;KIF18A -0.73 -12.89 -0.58 3.95e-31 Bipolar disorder; LUSC cis rs2839186 0.967 rs9637172 chr21:47685787 T/C cg13012494 chr21:47604986 C21orf56 0.39 5.76 0.3 1.9e-8 Testicular germ cell tumor; LUSC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg27286337 chr10:134555280 INPP5A 0.76 11.31 0.53 2.58e-25 Migraine; LUSC trans rs747782 0.528 rs624348 chr11:48400795 G/A cg03929089 chr4:120376271 NA -0.64 -5.98 -0.31 5.65e-9 Intraocular pressure; LUSC cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.73e-15 Homoarginine levels; LUSC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg22655196 chr4:3374909 RGS12 0.3 5.76 0.3 1.95e-8 Serum sulfate level; LUSC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg03264133 chr6:25882463 NA 0.63 10.68 0.5 4.18e-23 Blood metabolite levels; LUSC cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg25019033 chr10:957182 NA -0.58 -7.66 -0.39 2.04e-13 Eosinophil percentage of granulocytes; LUSC trans rs7829975 0.742 rs7832968 chr8:8652889 G/A cg21775007 chr8:11205619 TDH 0.49 6.92 0.35 2.32e-11 Mood instability; LUSC cis rs73198271 1.000 rs11774744 chr8:8607764 A/G cg01851573 chr8:8652454 MFHAS1 0.57 8.08 0.4 1.22e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1018836 0.923 rs10808615 chr8:91569704 A/T cg16814680 chr8:91681699 NA -0.76 -12.82 -0.57 7.37e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg11344533 chr11:111475393 SIK2 -0.47 -6.45 -0.33 3.83e-10 Primary sclerosing cholangitis; LUSC trans rs3774749 0.565 rs2188151 chr3:50201924 A/C cg21659725 chr3:3221576 CRBN -0.51 -7.9 -0.4 4.08e-14 Intelligence (multi-trait analysis); LUSC cis rs701145 0.585 rs1620712 chr3:153790050 C/G cg17054900 chr3:154042577 DHX36 0.54 5.73 0.3 2.3e-8 Coronary artery disease; LUSC cis rs765787 0.530 rs11854294 chr15:45527996 A/G cg24006582 chr15:45444508 DUOX1 -0.61 -9.03 -0.44 1.43e-17 Uric acid levels; LUSC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg11366901 chr6:160182831 ACAT2 0.94 13.12 0.58 5.38e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg05738196 chr6:26577821 NA 0.79 15.32 0.64 1.73e-40 Intelligence (multi-trait analysis); LUSC cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg26408565 chr15:76604113 ETFA -0.43 -6.75 -0.35 6.62e-11 Blood metabolite levels; LUSC trans rs17685 0.671 rs60303271 chr7:75760008 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9921338 1.000 rs8055427 chr16:11436883 T/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.67 -0.34 1.07e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs4629180 1.000 rs11123889 chr2:102107180 G/A cg01388757 chr2:102091195 RFX8 0.47 7.6 0.38 3.06e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.9 0.77 1.58e-66 Prudent dietary pattern; LUSC cis rs9653442 0.900 rs10194635 chr2:100834217 T/A cg07810366 chr2:100720526 AFF3 -0.47 -8.11 -0.41 9.73e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.26 0.52 3.74e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.03e-34 Prostate cancer; LUSC cis rs6728642 0.572 rs1320147 chr2:97600626 A/C cg26665480 chr2:98280029 ACTR1B 0.74 7.49 0.38 6.13e-13 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs3925075 0.764 rs8044482 chr16:31345752 T/C cg02846316 chr16:31340340 ITGAM 0.36 6.61 0.34 1.56e-10 IgA nephropathy; LUSC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.82 0.39 6.97e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg19622623 chr12:86230825 RASSF9 -0.42 -6.01 -0.31 4.85e-9 Major depressive disorder; LUSC cis rs12594515 1.000 rs56412446 chr15:45996424 A/G cg01629716 chr15:45996671 NA 0.39 5.87 0.31 1.08e-8 Waist circumference;Weight; LUSC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.87 0.4 4.98e-14 Major depressive disorder; LUSC cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg01028140 chr2:1542097 TPO -0.37 -5.97 -0.31 6.12e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg09904177 chr6:26538194 HMGN4 0.47 7.47 0.38 7.28e-13 Schizophrenia; LUSC cis rs7605827 0.675 rs55977282 chr2:15691791 G/T cg19274914 chr2:15703543 NA -0.45 -8.05 -0.4 1.43e-14 Educational attainment (years of education); LUSC cis rs11190604 1.000 rs2495755 chr10:102324649 A/C cg07080220 chr10:102295463 HIF1AN 0.7 8.39 0.42 1.39e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.67 0.6 4.14e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7819412 0.775 rs2001329 chr8:10986859 C/T cg21775007 chr8:11205619 TDH -0.51 -7.55 -0.38 4.06e-13 Triglycerides; LUSC cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg13010199 chr12:38710504 ALG10B 0.66 10.32 0.49 7.69e-22 Bladder cancer; LUSC cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.65 -10.38 -0.49 4.61e-22 Systemic lupus erythematosus; LUSC cis rs453301 0.653 rs7853 chr8:8890814 A/G cg06636001 chr8:8085503 FLJ10661 0.63 9.7 0.47 9e-20 Joint mobility (Beighton score); LUSC cis rs701145 0.938 rs355780 chr3:153978289 C/T cg17054900 chr3:154042577 DHX36 0.81 8.35 0.42 1.82e-15 Coronary artery disease; LUSC cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg05472934 chr7:22766657 IL6 0.41 6.52 0.34 2.64e-10 Lung cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09564133 chr5:176738847 MXD3 0.44 6.48 0.33 3.24e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg09033563 chr22:24373618 LOC391322 -0.48 -6.78 -0.35 5.33e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg16145915 chr7:1198662 ZFAND2A -0.62 -11.94 -0.55 1.34e-27 Longevity;Endometriosis; LUSC cis rs208520 0.690 rs12204512 chr6:66710486 C/T cg07460842 chr6:66804631 NA 1.09 17.17 0.68 8.31e-48 Exhaled nitric oxide output; LUSC trans rs984440 0.600 rs6999788 chr8:139079319 T/A cg03334052 chr1:168888044 NA -0.41 -6.45 -0.33 3.9e-10 Obesity-related traits; LUSC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg07395648 chr5:131743802 NA 0.39 6.5 0.34 2.92e-10 Breast cancer;Mosquito bite size; LUSC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg20818283 chr2:191399100 TMEM194B 0.49 7.35 0.37 1.5e-12 Pulse pressure; LUSC cis rs611744 0.506 rs4735054 chr8:109261780 A/C cg21045802 chr8:109455806 TTC35 -0.46 -7.08 -0.36 8.34e-12 Dupuytren's disease; LUSC cis rs62400317 0.859 rs55779653 chr6:45265960 C/T cg20913747 chr6:44695427 NA -0.45 -7.42 -0.38 9.97e-13 Total body bone mineral density; LUSC cis rs360798 0.512 rs2710637 chr2:63173450 G/A cg17519650 chr2:63277830 OTX1 0.48 6.86 0.35 3.25e-11 Coronary artery disease; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg22963979 chr7:1858916 MAD1L1 -0.56 -8.52 -0.42 5.7e-16 Bipolar disorder and schizophrenia; LUSC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg14581129 chr12:53358946 NA -0.61 -9.0 -0.44 1.79e-17 Prostate cancer; LUSC trans rs2262909 0.962 rs56369285 chr19:22267185 T/C cg05197062 chr11:11642011 GALNTL4 0.56 7.88 0.4 4.75e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs11923600 0.730 rs62285824 chr3:175891133 T/G cg02188190 chr13:112894616 NA 0.45 6.37 0.33 6.1e-10 Height; LUSC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg12310025 chr6:25882481 NA 0.63 10.55 0.5 1.17e-22 Blood metabolite levels; LUSC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg23262073 chr20:60523788 NA -0.42 -5.96 -0.31 6.32e-9 Body mass index; LUSC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg06484146 chr7:12443880 VWDE -0.73 -7.32 -0.37 1.89e-12 Coronary artery disease; LUSC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg13206674 chr6:150067644 NUP43 0.61 9.82 0.47 3.55e-20 Lung cancer; LUSC cis rs10904908 1.000 rs7903402 chr10:17259772 C/T cg01003015 chr10:17271136 VIM -0.43 -6.17 -0.32 2e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg21573476 chr21:45109991 RRP1B -0.41 -6.62 -0.34 1.42e-10 Mean corpuscular volume; LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg20887711 chr4:1340912 KIAA1530 0.42 6.51 0.34 2.77e-10 Obesity-related traits; LUSC cis rs7980687 0.628 rs2102949 chr12:123676763 G/A cg05973401 chr12:123451056 ABCB9 0.52 7.0 0.36 1.44e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.3e-8 Bipolar disorder (body mass index interaction); LUSC cis rs503341 0.756 rs612010 chr11:63591005 G/A cg04850017 chr11:63683019 RCOR2 0.29 5.79 0.3 1.6e-8 Pulse pressure; LUSC cis rs7914558 0.505 rs12260436 chr10:104741114 A/C cg05855489 chr10:104503620 C10orf26 0.52 6.73 0.35 7.28e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6961069 0.621 rs13222488 chr7:80240508 A/T cg04458919 chr7:80252533 CD36 -0.41 -7.2 -0.37 3.99e-12 Platelet count; LUSC trans rs7739264 0.563 rs9465516 chr6:19771998 A/C cg13431028 chr2:169073609 STK39 0.36 6.15 0.32 2.24e-9 Endometriosis; LUSC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg26314531 chr2:26401878 FAM59B -0.66 -9.25 -0.45 2.84e-18 Gut microbiome composition (summer); LUSC cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.08 -0.36 8.55e-12 Menopause (age at onset); LUSC cis rs7843479 0.965 rs17616085 chr8:21857267 C/T cg17168535 chr8:21777572 XPO7 0.63 9.58 0.46 2.31e-19 Mean corpuscular volume; LUSC cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg26384229 chr12:38710491 ALG10B 0.92 15.65 0.65 8.39e-42 Drug-induced liver injury (flucloxacillin); LUSC trans rs9291683 0.609 rs13141233 chr4:10028729 T/C cg26043149 chr18:55253948 FECH 0.51 7.52 0.38 5.09e-13 Bone mineral density; LUSC cis rs12462428 0.911 rs6512119 chr19:16665215 C/T cg05286348 chr19:16641544 CHERP -0.54 -6.17 -0.32 1.98e-9 Educational attainment (years of education); LUSC cis rs3768617 0.510 rs12078729 chr1:183060072 T/A ch.1.3577855R chr1:183094577 LAMC1 0.7 10.61 0.5 7.64e-23 Fuchs's corneal dystrophy; LUSC cis rs4077515 0.967 rs11145874 chr9:139290011 G/A cg14169450 chr9:139327907 INPP5E 0.43 7.57 0.38 3.61e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg08499158 chr17:42289980 UBTF -0.37 -6.0 -0.31 5.1e-9 Red cell distribution width;Reticulocyte count; LUSC cis rs10761482 0.500 rs1938538 chr10:62298233 T/C cg18175470 chr10:62150864 ANK3 -0.5 -7.23 -0.37 3.25e-12 Schizophrenia; LUSC cis rs9902453 0.765 rs2264303 chr17:28055348 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.4 -0.53 1.15e-25 Coffee consumption (cups per day); LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg26314531 chr2:26401878 FAM59B -0.71 -10.02 -0.48 7.96e-21 Gut microbiome composition (summer); LUSC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.71 -9.19 -0.45 4.14e-18 Gut microbiome composition (summer); LUSC cis rs472402 0.623 rs8192133 chr5:6636645 A/G cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.51 -7.69 -0.39 1.66e-13 Response to amphetamines; LUSC cis rs4660306 1.000 rs4660306 chr1:45978675 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.41 6.34 0.33 7.31e-10 Homocysteine levels; LUSC trans rs1005277 0.603 rs1998062 chr10:38457652 G/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.35 -0.46 1.34e-18 Extrinsic epigenetic age acceleration; LUSC cis rs3772130 0.962 rs11707504 chr3:121496734 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.23 0.49 1.48e-21 Cognitive performance; LUSC cis rs10782582 0.593 rs12129523 chr1:76129223 C/A cg10523679 chr1:76189770 ACADM -0.48 -7.11 -0.36 7.03e-12 Daytime sleep phenotypes; LUSC cis rs7909074 1.000 rs6593447 chr10:45400235 G/A cg04218760 chr10:45406644 TMEM72 -0.29 -6.88 -0.35 3.04e-11 Mean corpuscular volume; LUSC cis rs1163251 0.837 rs660073 chr1:120245173 T/C cg19096424 chr1:120255104 PHGDH 0.44 6.03 0.31 4.29e-9 Blood metabolite levels; LUSC cis rs28595532 0.920 rs17325192 chr4:119780345 A/G cg11846333 chr4:119757529 SEC24D -0.75 -6.64 -0.34 1.27e-10 Cannabis dependence symptom count; LUSC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg02187348 chr16:89574699 SPG7 0.58 9.55 0.46 2.99e-19 Multiple myeloma (IgH translocation); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20297566 chr3:99979976 TBC1D23 0.47 6.97 0.36 1.68e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T ch.3.55501R chr3:3184210 TRNT1 0.43 6.78 0.35 5.54e-11 Triglycerides; LUSC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg06363034 chr20:62225388 GMEB2 -0.46 -7.71 -0.39 1.45e-13 Glioblastoma; LUSC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg24154853 chr7:158122151 PTPRN2 0.44 8.77 0.43 9.32e-17 Calcium levels; LUSC cis rs6500395 1.000 rs7202551 chr16:48728984 A/G cg04672837 chr16:48644449 N4BP1 -0.47 -6.95 -0.36 1.9e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg22868518 chr11:507468 RNH1 -0.63 -6.2 -0.32 1.69e-9 Body mass index; LUSC cis rs7799006 0.929 rs35791351 chr7:2269248 C/T cg08027265 chr7:2291960 NA -0.43 -7.4 -0.38 1.12e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8141529 0.748 rs132531 chr22:29297365 C/T cg15103426 chr22:29168792 CCDC117 -0.44 -5.67 -0.3 3.03e-8 Lymphocyte counts; LUSC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.65 5.68 0.3 2.87e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg27170947 chr2:26402098 FAM59B -0.65 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC trans rs12310956 0.532 rs11052930 chr12:33964824 A/G cg26384229 chr12:38710491 ALG10B 0.75 11.85 0.54 2.85e-27 Morning vs. evening chronotype; LUSC cis rs9354352 0.935 rs9345749 chr6:66699892 G/T cg07460842 chr6:66804631 NA -0.47 -6.85 -0.35 3.64e-11 Initial pursuit acceleration in psychotic disorders; LUSC cis rs4930561 0.739 rs10896303 chr11:67974292 C/A cg16338278 chr11:67432957 ALDH3B2 0.4 6.75 0.35 6.73e-11 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg08067268 chr2:26466485 HADHB;HADHA 0.4 5.93 0.31 7.73e-9 Gut microbiome composition (summer); LUSC trans rs11923600 0.793 rs11718762 chr3:175890798 G/T cg02188190 chr13:112894616 NA 0.42 6.06 0.31 3.67e-9 Height; LUSC cis rs7824557 0.628 rs11782706 chr8:11186215 A/C cg21293242 chr8:11204541 TDH 0.34 6.38 0.33 5.92e-10 Retinal vascular caliber; LUSC cis rs1451375 0.755 rs6969081 chr7:50624505 A/T cg18232548 chr7:50535776 DDC 0.52 7.93 0.4 3.22e-14 Malaria; LUSC cis rs7173743 0.756 rs11852830 chr15:79125429 A/T cg00540400 chr15:79124168 NA 0.36 6.1 0.32 2.98e-9 Coronary artery disease; LUSC cis rs6542838 0.702 rs6419564 chr2:99534113 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.04 -0.36 1.1e-11 Fear of minor pain; LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg04944784 chr2:26401820 FAM59B 0.77 11.23 0.52 4.85e-25 Gut microbiome composition (summer); LUSC cis rs472402 0.560 rs6874005 chr5:6624371 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.41 -5.91 -0.31 8.61e-9 Response to amphetamines; LUSC cis rs6981523 0.500 rs4412337 chr8:11072020 C/T cg21775007 chr8:11205619 TDH 0.51 7.14 0.36 5.93e-12 Neuroticism; LUSC cis rs9653442 0.564 rs2164711 chr2:100775422 G/T cg07810366 chr2:100720526 AFF3 -0.44 -7.61 -0.38 2.74e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6087771 0.682 rs2038397 chr20:30217759 A/G cg21427119 chr20:30132790 HM13 -0.38 -5.98 -0.31 5.75e-9 Subcortical brain region volumes;Putamen volume; LUSC trans rs2262909 0.962 rs409439 chr19:22227432 C/T cg05197062 chr11:11642011 GALNTL4 -0.56 -7.81 -0.39 7.34e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg20587970 chr11:113659929 NA -1.28 -17.65 -0.69 1.05e-49 Hip circumference adjusted for BMI; LUSC trans rs9329221 0.736 rs2001338 chr8:10251217 A/G cg08975724 chr8:8085496 FLJ10661 0.45 6.04 0.31 4.01e-9 Neuroticism; LUSC cis rs35883536 0.647 rs7535762 chr1:101047534 A/G cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC cis rs1348850 0.914 rs12693120 chr2:178283288 A/G cg22681709 chr2:178499509 PDE11A -0.5 -9.17 -0.45 4.88e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -7.32 -0.37 1.92e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg06462663 chr19:18546047 ISYNA1 0.48 8.12 0.41 9.32e-15 Breast cancer; LUSC trans rs7937682 0.924 rs6589244 chr11:111534333 T/C cg18187862 chr3:45730750 SACM1L 0.55 6.91 0.35 2.52e-11 Primary sclerosing cholangitis; LUSC cis rs11585357 0.895 rs2977305 chr1:17613737 A/T cg08277548 chr1:17600880 PADI3 0.62 6.51 0.34 2.72e-10 Hair shape; LUSC trans rs853679 0.607 rs13199772 chr6:27834085 A/G cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.13e-9 Depression; LUSC cis rs2204008 0.569 rs11495449 chr12:37995753 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.76 0.65 3.19e-42 Bladder cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25375453 chr3:14219857 LSM3;XPC -0.42 -6.36 -0.33 6.68e-10 Electrocardiographic conduction measures; LUSC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg08975724 chr8:8085496 FLJ10661 0.51 7.63 0.39 2.55e-13 Mood instability; LUSC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.27 0.32 1.15e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.36 7.36 0.37 1.46e-12 Hemoglobin concentration; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg25428297 chr7:1022841 CYP2W1 0.31 6.49 0.33 3.02e-10 Longevity;Endometriosis; LUSC cis rs12973672 1.000 rs10421768 chr19:35772899 A/G cg12095397 chr19:35769544 USF2 0.41 6.38 0.33 5.82e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs644799 0.562 rs671320 chr11:95578780 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.65 10.39 0.49 4.3e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.3 0.56 6.22e-29 Motion sickness; LUSC cis rs7712401 0.755 rs13172043 chr5:122184759 G/A cg19077854 chr5:122220652 SNX24 0.36 8.24 0.41 4.02e-15 Mean platelet volume; LUSC cis rs7772486 0.902 rs2777480 chr6:146309983 T/A cg05347473 chr6:146136440 FBXO30 0.43 7.04 0.36 1.11e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg06637938 chr14:75390232 RPS6KL1 -0.53 -8.37 -0.42 1.57e-15 Height; LUSC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11644478 chr21:40555479 PSMG1 -0.55 -7.99 -0.4 2.2e-14 Menarche (age at onset); LUSC cis rs17270561 0.636 rs9348696 chr6:25781938 A/G cg16482183 chr6:26056742 HIST1H1C 0.57 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC trans rs2386661 0.712 rs11259544 chr10:5646708 T/C cg11398623 chr21:37499189 NA 0.26 6.03 0.31 4.25e-9 Breast cancer; LUSC cis rs7615316 1.000 rs7646880 chr3:142351930 C/T cg16271453 chr3:142027066 XRN1 -0.35 -5.99 -0.31 5.54e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.27 0.45 2.34e-18 Prudent dietary pattern; LUSC cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg12011299 chr4:100065546 ADH4 0.73 11.05 0.52 2.14e-24 Alcohol dependence; LUSC cis rs1593 0.734 rs4253407 chr4:187193308 A/T cg09526685 chr4:187126073 CYP4V2 0.57 5.8 0.3 1.51e-8 Activated partial thromboplastin time; LUSC cis rs8063761 0.689 rs4785763 chr16:90066936 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.59 -8.68 -0.43 1.75e-16 Squamous cell carcinoma; LUSC cis rs7617773 0.817 rs13072018 chr3:48320332 G/A cg20734569 chr3:48348370 SPINK8 -0.48 -8.13 -0.41 8.72e-15 Coronary artery disease; LUSC cis rs4566357 0.615 rs3769642 chr2:227917323 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -8.13 -0.41 8.48e-15 Coronary artery disease; LUSC cis rs151234 0.800 rs231974 chr16:28540322 A/T cg01378222 chr16:28622494 SULT1A1 -0.61 -7.86 -0.4 5.37e-14 Platelet distribution width; LUSC cis rs66887589 0.934 rs7681980 chr4:120533223 G/A cg24375607 chr4:120327624 NA -0.48 -7.47 -0.38 7.22e-13 Diastolic blood pressure; LUSC cis rs7520050 0.778 rs2991985 chr1:46080530 T/C cg24296786 chr1:45957014 TESK2 0.46 6.51 0.34 2.83e-10 Red blood cell count;Reticulocyte count; LUSC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.51 0.67 3.48e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04578738 chr17:34136331 TAF15 0.44 6.28 0.32 1.06e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.83 0.3 1.28e-8 Menopause (age at onset); LUSC cis rs637571 0.544 rs56239996 chr11:65730003 A/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 9.63 0.47 1.53e-19 Eosinophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14677912 chr5:140019017 TMCO6 -0.37 -6.19 -0.32 1.8e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg17143192 chr8:8559678 CLDN23 0.64 9.29 0.45 2.01e-18 Obesity-related traits; LUSC cis rs6120849 0.707 rs6120799 chr20:33614955 T/C cg24642439 chr20:33292090 TP53INP2 0.61 6.74 0.35 6.84e-11 Protein C levels; LUSC cis rs10876993 0.928 rs2640629 chr12:58065448 C/T cg18357645 chr12:58087776 OS9 0.53 8.0 0.4 2.09e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg08677398 chr8:58056175 NA 0.58 6.95 0.36 1.96e-11 Developmental language disorder (linguistic errors); LUSC cis rs6456156 0.755 rs4710182 chr6:167514061 G/A cg07741184 chr6:167504864 NA 0.37 6.46 0.33 3.62e-10 Primary biliary cholangitis; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg24846343 chr22:24311635 DDTL 0.77 17.41 0.69 9.4e-49 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4969178 0.965 rs8072632 chr17:76397830 T/C cg05887092 chr17:76393375 PGS1 0.55 9.79 0.47 4.62e-20 HDL cholesterol levels; LUSC cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg23711669 chr6:146136114 FBXO30 0.75 13.38 0.59 5.42e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs765787 0.530 rs12909987 chr15:45512207 C/T cg24006582 chr15:45444508 DUOX1 -0.62 -9.22 -0.45 3.51e-18 Uric acid levels; LUSC cis rs6845621 0.966 rs2048961 chr4:18861390 C/T cg12196642 chr4:18937545 NA -0.32 -5.99 -0.31 5.28e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg26115276 chr5:178977181 RUFY1 0.37 5.95 0.31 6.85e-9 Schizophrenia; LUSC cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg05347473 chr6:146136440 FBXO30 0.52 8.67 0.43 1.87e-16 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.908 rs7695996 chr4:120322033 C/T cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg14895029 chr7:2775587 GNA12 -0.36 -5.69 -0.3 2.8e-8 Height; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg15057150 chr1:206680618 RASSF5 0.44 7.25 0.37 2.96e-12 Schizophrenia; LUSC trans rs61931739 0.649 rs815046 chr12:33720602 C/T cg26384229 chr12:38710491 ALG10B 0.43 6.24 0.32 1.36e-9 Morning vs. evening chronotype; LUSC cis rs950027 0.549 rs11070452 chr15:45594836 C/A cg09092052 chr15:45571596 NA 0.48 6.75 0.35 6.71e-11 Response to fenofibrate (adiponectin levels); LUSC cis rs8044995 0.563 rs3785127 chr16:68399590 C/G cg05110241 chr16:68378359 PRMT7 -0.78 -8.89 -0.44 3.82e-17 Schizophrenia; LUSC trans rs11098499 0.866 rs11098506 chr4:120284971 A/G cg25214090 chr10:38739885 LOC399744 0.5 7.57 0.38 3.68e-13 Corneal astigmatism; LUSC cis rs4664308 1.000 rs2175416 chr2:160904021 G/A cg03641300 chr2:160917029 PLA2R1 -0.66 -11.21 -0.52 5.69e-25 Idiopathic membranous nephropathy; LUSC cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.18 -0.45 4.65e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1413885 0.516 rs1591364 chr1:65842364 T/G cg14976592 chr1:65886160 LEPROT;LEPR 0.5 7.51 0.38 5.61e-13 Anticoagulant levels; LUSC cis rs9837602 1.000 rs704582 chr3:99571926 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.89 -0.31 9.63e-9 Breast cancer; LUSC cis rs7267979 1.000 rs2424700 chr20:25266513 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.54 0.75 3.49e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10761482 0.861 rs4245588 chr10:62101746 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg11984989 chr7:158649758 WDR60 1.07 21.81 0.77 3.37e-66 Height; LUSC cis rs7804356 0.953 rs3801822 chr7:26861201 T/C cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg12311346 chr5:56204834 C5orf35 0.82 13.45 0.59 3.05e-33 Initial pursuit acceleration; LUSC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.5 7.61 0.38 2.87e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg19468946 chr17:37922297 IKZF3 -0.43 -6.82 -0.35 4.17e-11 Self-reported allergy; LUSC cis rs4654899 0.865 rs957163 chr1:21416181 G/T cg01072550 chr1:21505969 NA -0.52 -7.6 -0.38 2.99e-13 Superior frontal gyrus grey matter volume; LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs4888262 0.508 rs7193583 chr16:74649589 C/G cg01733217 chr16:74700730 RFWD3 0.8 13.34 0.59 8.02e-33 Testicular germ cell tumor; LUSC cis rs6693567 0.565 rs3754217 chr1:150480373 G/T cg15654264 chr1:150340011 RPRD2 0.45 7.17 0.37 4.91e-12 Migraine; LUSC trans rs11088226 0.681 rs11700670 chr21:33938615 T/C cg09050820 chr6:167586206 TCP10L2 0.73 9.47 0.46 5.31e-19 Gastritis; LUSC cis rs9611565 0.649 rs2413659 chr22:42164862 A/G cg17376030 chr22:41985996 PMM1 -0.42 -5.71 -0.3 2.56e-8 Vitiligo; LUSC cis rs4776059 1.000 rs11853917 chr15:52922054 T/C cg22715398 chr15:52968154 KIAA1370 -0.65 -9.54 -0.46 3.02e-19 Schizophrenia; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.54 0.76 3.92e-65 Prudent dietary pattern; LUSC cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg23788917 chr6:8435910 SLC35B3 0.51 7.62 0.38 2.58e-13 Motion sickness; LUSC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.55 0.34 2.22e-10 Lung cancer; LUSC cis rs11608355 0.846 rs61934479 chr12:109855111 A/G cg19025524 chr12:109796872 NA -0.39 -5.72 -0.3 2.35e-8 Neuroticism; LUSC cis rs6700896 0.500 rs12130476 chr1:66124850 G/C cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.11 14.84 0.63 1.26e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1577917 0.958 rs10944137 chr6:86454314 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.5 -7.21 -0.37 3.69e-12 Response to antipsychotic treatment; LUSC cis rs11958404 0.932 rs72818104 chr5:157437632 T/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2795502 1.000 rs2795497 chr10:43339475 C/A cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs7264396 0.563 rs56941405 chr20:34313426 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.49 -0.42 6.89e-16 Total cholesterol levels; LUSC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg13770153 chr20:60521292 NA -0.64 -8.6 -0.43 3.17e-16 Body mass index; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg00149659 chr3:10157352 C3orf10 -0.83 -12.13 -0.55 2.64e-28 Alzheimer's disease; LUSC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg05535760 chr7:792225 HEATR2 0.91 9.61 0.47 1.88e-19 Cerebrospinal P-tau181p levels; LUSC cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg03433033 chr1:76189801 ACADM 0.65 8.86 0.44 4.71e-17 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs9329221 0.716 rs11989640 chr8:10256054 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.01 -0.36 1.3e-11 Neuroticism; LUSC trans rs2204008 0.683 rs11519834 chr12:38053575 T/A cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.25e-9 Bladder cancer; LUSC cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg18252515 chr7:66147081 NA -0.57 -7.95 -0.4 2.87e-14 Corneal structure; LUSC cis rs2832077 0.943 rs2832084 chr21:30154798 A/G cg24692254 chr21:30365293 RNF160 -0.54 -6.65 -0.34 1.23e-10 Cognitive test performance; LUSC trans rs629535 1.000 rs644951 chr8:70009082 C/T cg21567404 chr3:27674614 NA -0.86 -13.03 -0.58 1.2e-31 Dupuytren's disease; LUSC cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg03146154 chr1:46216737 IPP -0.51 -7.73 -0.39 1.3e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7465272 1.000 rs7465272 chr8:143691838 A/T cg10104451 chr8:143696006 ARC -0.64 -9.07 -0.44 1.06e-17 Bipolar disorder and schizophrenia; LUSC cis rs10911232 0.507 rs4652766 chr1:182994336 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.05 0.52 2.14e-24 Hypertriglyceridemia; LUSC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg20243544 chr17:37824526 PNMT 0.43 6.54 0.34 2.28e-10 Self-reported allergy; LUSC trans rs61931739 0.500 rs7977194 chr12:34408459 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.83 0.51 1.27e-23 Morning vs. evening chronotype; LUSC cis rs1055129 0.560 rs56248937 chr17:73915153 T/A cg17515076 chr17:73810948 UNK -0.4 -6.72 -0.35 7.94e-11 White matter hyperintensity burden; LUSC cis rs11190604 0.767 rs10883491 chr10:102196071 G/T cg07080220 chr10:102295463 HIF1AN 0.61 8.14 0.41 8.11e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg15147215 chr3:52552868 STAB1 -0.29 -5.83 -0.3 1.28e-8 Bipolar disorder; LUSC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3782089 1.000 rs11602375 chr11:65296540 C/T cg08676812 chr11:65308423 LTBP3 1.06 6.8 0.35 4.71e-11 Height; LUSC cis rs12101261 0.890 rs3783947 chr14:81449534 T/C cg06600135 chr14:81408086 NA 0.42 6.33 0.33 7.96e-10 Graves' disease; LUSC cis rs6977660 1.000 rs2107403 chr7:19819025 G/C cg07541023 chr7:19748670 TWISTNB 0.51 5.82 0.3 1.37e-8 Thyroid stimulating hormone; LUSC trans rs12579753 0.917 rs2401002 chr12:82215870 C/T cg07923666 chr12:49932857 KCNH3 -0.49 -6.12 -0.32 2.55e-9 Resting heart rate; LUSC cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg09184832 chr6:79620586 NA -0.41 -6.3 -0.33 9.47e-10 Intelligence (multi-trait analysis); LUSC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg10253484 chr15:75165896 SCAMP2 -0.5 -7.57 -0.38 3.64e-13 Breast cancer; LUSC cis rs7666738 0.512 rs165251 chr4:98758490 C/G cg05340658 chr4:99064831 C4orf37 0.44 6.85 0.35 3.55e-11 Colonoscopy-negative controls vs population controls; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21415643 chr1:42127431 HIVEP3 -0.42 -6.16 -0.32 2.04e-9 Electrocardiographic conduction measures; LUSC cis rs7107174 0.892 rs1007837 chr11:77941076 A/G cg02023728 chr11:77925099 USP35 0.48 6.84 0.35 3.78e-11 Testicular germ cell tumor; LUSC trans rs35110281 0.693 rs2838344 chr21:45089877 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.86 0.47 2.6e-20 Mean corpuscular volume; LUSC trans rs7647973 0.626 rs62260723 chr3:49872124 T/C cg21659725 chr3:3221576 CRBN 0.72 8.76 0.43 1.01e-16 Menarche (age at onset); LUSC cis rs1943345 1.000 rs1943345 chr11:82876270 G/T cg07047830 chr11:82868014 PCF11 -0.51 -7.25 -0.37 2.93e-12 Obesity-related traits; LUSC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg10802521 chr3:52805072 NEK4 -0.57 -9.37 -0.46 1.13e-18 Electroencephalogram traits; LUSC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg11764359 chr7:65958608 NA -0.52 -6.78 -0.35 5.48e-11 Aortic root size; LUSC cis rs2637266 0.905 rs1978925 chr10:78399879 C/T cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs2835872 0.698 rs2898318 chr21:38986690 C/G cg20424643 chr21:39039972 KCNJ6 0.4 6.09 0.32 3.05e-9 Electroencephalographic traits in alcoholism; LUSC cis rs11122272 0.732 rs2808605 chr1:231540187 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.3 -0.49 8.36e-22 Hemoglobin concentration; LUSC cis rs6845621 0.717 rs13114942 chr4:18843090 A/T cg12196642 chr4:18937545 NA -0.31 -5.7 -0.3 2.61e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg24101359 chr6:42928495 GNMT 0.36 5.9 0.31 8.69e-9 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg21153622 chr11:89784906 NA -0.39 -6.0 -0.31 5.01e-9 HDL cholesterol; LUSC cis rs7617773 0.780 rs6442111 chr3:48312060 G/C cg20734569 chr3:48348370 SPINK8 -0.48 -8.29 -0.41 2.74e-15 Coronary artery disease; LUSC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg03433033 chr1:76189801 ACADM -0.74 -10.75 -0.51 2.36e-23 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs12210905 0.688 rs72839474 chr6:27324757 T/C cg02699829 chr19:13216355 TRMT1 -0.56 -6.23 -0.32 1.39e-9 Hip circumference adjusted for BMI; LUSC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg15445000 chr17:37608096 MED1 -0.4 -6.73 -0.35 7.36e-11 Glomerular filtration rate (creatinine); LUSC cis rs1065852 0.526 rs59993856 chr22:42403980 C/T cg22189786 chr22:42395067 WBP2NL 0.43 5.78 0.3 1.72e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs939574 0.720 rs6714820 chr2:220071803 C/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.95 -8.17 -0.41 6.53e-15 Platelet distribution width; LUSC cis rs137699 1.000 rs2049986 chr22:39756854 C/G cg24399712 chr22:39784796 NA 0.41 6.84 0.35 3.74e-11 IgG glycosylation; LUSC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg16325326 chr1:53192061 ZYG11B 0.95 17.75 0.7 3.99e-50 Monocyte count; LUSC cis rs7100689 0.577 rs10749551 chr10:82054001 A/C cg00277334 chr10:82204260 NA -0.45 -6.34 -0.33 7.39e-10 Post bronchodilator FEV1; LUSC cis rs5769707 0.935 rs9616332 chr22:50047678 C/G cg20744362 chr22:50050164 C22orf34 0.42 8.68 0.43 1.79e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg14552801 chr7:65878734 NA -0.37 -5.79 -0.3 1.67e-8 Aortic root size; LUSC cis rs11098499 0.645 rs78422072 chr4:120281042 C/T cg24375607 chr4:120327624 NA 0.69 10.26 0.49 1.17e-21 Corneal astigmatism; LUSC trans rs1941687 0.831 rs11877286 chr18:31386764 T/C cg27147174 chr7:100797783 AP1S1 -0.46 -6.84 -0.35 3.68e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs17604090 0.938 rs68072609 chr7:29682467 C/T cg19413766 chr7:29689036 LOC646762 -0.62 -7.11 -0.36 7.3e-12 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs2073300 1.000 rs6114142 chr20:23461082 A/G cg09953122 chr20:23471693 CST8 -0.75 -7.29 -0.37 2.2e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9399135 0.935 rs4273704 chr6:135297520 G/T cg24558204 chr6:135376177 HBS1L 0.58 9.0 0.44 1.69e-17 Red blood cell count; LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.19 0.32 1.77e-9 Menopause (age at onset); LUSC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs9517320 1.000 rs9517322 chr13:99126338 C/G cg20487152 chr13:99095054 FARP1 0.34 6.35 0.33 6.84e-10 Longevity; LUSC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg06481639 chr22:41940642 POLR3H 0.5 5.77 0.3 1.81e-8 Vitiligo; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg23478354 chr19:59010761 SLC27A5 0.38 6.26 0.32 1.19e-9 Schizophrenia; LUSC cis rs908922 0.582 rs1856121 chr1:152512169 A/T cg20991723 chr1:152506922 NA 0.51 9.48 0.46 4.74e-19 Hair morphology; LUSC cis rs977987 0.835 rs1010630 chr16:75328591 G/T cg03315344 chr16:75512273 CHST6 0.51 9.6 0.47 1.91e-19 Dupuytren's disease; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg13628971 chr7:2884303 GNA12 0.47 6.59 0.34 1.73e-10 Height; LUSC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg17143192 chr8:8559678 CLDN23 0.37 5.73 0.3 2.29e-8 Mood instability; LUSC cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg12863693 chr15:85201151 NMB 0.39 8.1 0.41 1.06e-14 Schizophrenia; LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11644478 chr21:40555479 PSMG1 0.82 14.91 0.63 6.87e-39 Cognitive function; LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs9303401 0.625 rs34963822 chr17:56988424 C/A cg25039879 chr17:56429692 SUPT4H1 0.68 9.09 0.45 8.81e-18 Cognitive test performance; LUSC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg08847533 chr14:75593920 NEK9 0.84 15.41 0.64 7.3400000000000005e-41 Height; LUSC cis rs10193935 0.901 rs13384323 chr2:42631346 C/T cg27598129 chr2:42591480 NA -0.58 -7.96 -0.4 2.63e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.9 -0.35 2.69e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg21724239 chr8:58056113 NA 0.72 7.25 0.37 2.88e-12 Developmental language disorder (linguistic errors); LUSC cis rs7824557 0.591 rs2736283 chr8:11225910 A/G cg21775007 chr8:11205619 TDH -0.71 -11.44 -0.53 8.82e-26 Retinal vascular caliber; LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.39 0.46 9.37e-19 Bipolar disorder; LUSC cis rs117851058 0.590 rs2607412 chr19:41268243 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.64 5.84 0.3 1.27e-8 Post bronchodilator FEV1; LUSC cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.56 -0.6 1.12e-33 Chronic sinus infection; LUSC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg06484146 chr7:12443880 VWDE -0.74 -7.3 -0.37 2.18e-12 Coronary artery disease; LUSC cis rs6426558 0.502 rs1929858 chr1:227220175 C/A cg10327440 chr1:227177885 CDC42BPA 0.59 7.93 0.4 3.32e-14 Neutrophil percentage of white cells; LUSC cis rs7615952 0.546 rs2979350 chr3:125362215 T/C cg05084668 chr3:125655381 ALG1L -0.42 -5.66 -0.3 3.33e-8 Blood pressure (smoking interaction); LUSC cis rs877282 0.945 rs877280 chr10:771599 C/T cg17470449 chr10:769945 NA 0.56 7.69 0.39 1.67e-13 Uric acid levels; LUSC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.76 -0.39 1.04e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.720 rs883810 chr1:152941345 T/C cg00922841 chr1:152955080 SPRR1A -0.4 -6.64 -0.34 1.3100000000000001e-10 Inflammatory skin disease; LUSC cis rs11098499 0.954 rs13113483 chr4:120309039 C/T cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6845621 0.901 rs1452555 chr4:18926504 G/A cg12196642 chr4:18937545 NA -0.36 -6.66 -0.34 1.11e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs62458065 0.640 rs6950077 chr7:32502895 A/G cg00845942 chr12:64062724 DPY19L2 0.55 6.75 0.35 6.43e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2963155 0.518 rs853184 chr5:142640901 C/T cg17617527 chr5:142782415 NR3C1 0.71 8.61 0.43 2.89e-16 Breast cancer; LUSC cis rs7809950 0.773 rs62483722 chr7:107186349 C/T cg23024343 chr7:107201750 COG5 -0.55 -8.7 -0.43 1.53e-16 Coronary artery disease; LUSC cis rs77216612 1.000 rs77216612 chr12:12877983 A/G cg09462578 chr12:12878428 APOLD1 -1.0 -17.1 -0.68 1.56e-47 Lymphocyte counts; LUSC trans rs4332037 0.539 rs11764780 chr7:2020904 G/C cg11693508 chr17:37793320 STARD3 0.6 7.12 0.36 6.69e-12 Bipolar disorder; LUSC cis rs1322512 0.917 rs2800624 chr6:153005247 G/A cg27316956 chr6:152958899 SYNE1 0.36 6.11 0.32 2.76e-9 Tonometry; LUSC cis rs896854 0.573 rs13271375 chr8:95853907 A/G cg13393036 chr8:95962371 TP53INP1 -0.43 -9.16 -0.45 5.45e-18 Type 2 diabetes; LUSC cis rs9902453 0.934 rs11080120 chr17:28507021 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.52 0.42 5.37e-16 Coffee consumption (cups per day); LUSC cis rs9467773 1.000 rs4871 chr6:26545632 G/A cg09904177 chr6:26538194 HMGN4 0.75 14.28 0.62 1.96e-36 Intelligence (multi-trait analysis); LUSC cis rs76878669 0.561 rs10896111 chr11:66115690 T/C cg18002602 chr11:66138449 SLC29A2 -0.48 -8.44 -0.42 9.66e-16 Educational attainment (years of education); LUSC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg05738196 chr6:26577821 NA -0.59 -6.85 -0.35 3.53e-11 Intelligence (multi-trait analysis); LUSC trans rs9291683 0.530 rs11723970 chr4:9980462 T/C cg26043149 chr18:55253948 FECH 0.47 7.16 0.36 5.06e-12 Bone mineral density; LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg19318889 chr4:1322082 MAEA 0.78 13.84 0.6 9.54e-35 Longevity; LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg11060661 chr22:24314208 DDT;DDTL 0.38 6.15 0.32 2.21e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs936229 0.768 rs11072509 chr15:75114374 C/G cg14664628 chr15:75095509 CSK -0.99 -16.83 -0.68 1.86e-46 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs757081 0.634 rs17472942 chr11:17094702 A/G cg15432903 chr11:17409602 KCNJ11 -0.39 -6.05 -0.31 3.98e-9 Systolic blood pressure; LUSC cis rs4730250 0.581 rs3779500 chr7:106792704 T/C cg02696742 chr7:106810147 HBP1 0.64 9.04 0.44 1.32e-17 Osteoarthritis; LUSC cis rs7100689 0.622 rs10749595 chr10:82172975 C/T cg01528321 chr10:82214614 TSPAN14 1.09 17.18 0.68 7.64e-48 Post bronchodilator FEV1; LUSC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.09e-11 Blood metabolite levels; LUSC cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg09184832 chr6:79620586 NA -0.43 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); LUSC cis rs1790761 0.967 rs1476792 chr11:67196237 A/G cg24690094 chr11:67383802 NA -0.32 -5.83 -0.3 1.29e-8 Mean corpuscular volume; LUSC cis rs10761482 0.600 rs1572843 chr10:62226980 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.7 -0.34 8.77e-11 Schizophrenia; LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg00814883 chr7:100076585 TSC22D4 -0.69 -9.31 -0.45 1.71e-18 Platelet count; LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03934478 chr11:495069 RNH1 0.81 9.94 0.48 1.41e-20 Body mass index; LUSC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs701145 0.585 rs357476 chr3:153892844 A/G cg10247383 chr3:153839028 SGEF 0.64 5.91 0.31 8.28e-9 Coronary artery disease; LUSC trans rs35110281 0.776 rs1073522 chr21:45009219 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 11.07 0.52 1.78e-24 Mean corpuscular volume; LUSC cis rs12540874 0.542 rs4947582 chr7:50566090 C/T cg18232548 chr7:50535776 DDC -0.57 -8.47 -0.42 7.79e-16 Systemic sclerosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08163220 chr3:31574309 STT3B 0.47 6.88 0.35 2.9100000000000002e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg05347473 chr6:146136440 FBXO30 0.56 9.73 0.47 7.22e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.63 -0.34 1.38e-10 Monocyte percentage of white cells; LUSC cis rs2274273 0.870 rs11625423 chr14:55795913 G/A cg04306507 chr14:55594613 LGALS3 0.54 11.81 0.54 3.97e-27 Protein biomarker; LUSC cis rs2901656 0.701 rs10911786 chr1:172448717 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.29 5.76 0.3 1.88e-8 Red cell distribution width;Platelet distribution width; LUSC cis rs11098499 0.535 rs7671759 chr4:120248094 A/C cg09307838 chr4:120376055 NA 0.69 10.25 0.49 1.27e-21 Corneal astigmatism; LUSC cis rs7495132 0.526 rs60433006 chr15:91197475 C/T cg05609160 chr15:91208370 NA -0.4 -5.78 -0.3 1.69e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs1788820 0.871 rs1623003 chr18:21165163 C/T cg14672496 chr18:21087552 C18orf8 0.43 6.75 0.35 6.59e-11 Body mass index; LUSC cis rs13040088 0.518 rs2427452 chr20:61577275 T/C cg23096297 chr20:61557774 DIDO1 -0.71 -9.56 -0.46 2.72e-19 Menopause (age at onset); LUSC cis rs17253792 1.000 rs17253792 chr14:56205030 T/C cg01858014 chr14:56050164 KTN1 -0.89 -6.69 -0.34 9.39e-11 Putamen volume; LUSC cis rs61931739 0.635 rs7138254 chr12:33914422 G/T cg06521331 chr12:34319734 NA -0.41 -6.67 -0.34 1.04e-10 Morning vs. evening chronotype; LUSC trans rs6977660 0.607 rs10243965 chr7:19797893 G/A cg16620390 chr12:125670262 NA -0.47 -6.07 -0.32 3.5e-9 Thyroid stimulating hormone; LUSC cis rs5758511 0.689 rs17478227 chr22:42654327 C/G cg12850546 chr22:42539477 CYP2D7P1 0.56 6.44 0.33 4.23e-10 Birth weight; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs9549260 0.755 rs9549252 chr13:41230141 A/G cg21288729 chr13:41239152 FOXO1 0.56 8.29 0.41 2.77e-15 Red blood cell count; LUSC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg13770153 chr20:60521292 NA -0.64 -8.6 -0.43 3.17e-16 Body mass index; LUSC cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg06484146 chr7:12443880 VWDE -0.58 -6.06 -0.31 3.66e-9 Coronary artery disease; LUSC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg04166393 chr7:2884313 GNA12 0.46 6.13 0.32 2.43e-9 Height; LUSC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg12257692 chr3:49977190 RBM6 -0.27 -7.54 -0.38 4.6e-13 Intelligence (multi-trait analysis); LUSC trans rs3118233 1 rs3118233 chr16:68733646 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.81 -12.31 -0.56 5.63e-29 Red cell distribution width; LUSC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg02423579 chr7:2872169 GNA12 -0.46 -6.43 -0.33 4.41e-10 Height; LUSC cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg00012203 chr2:219082015 ARPC2 -0.71 -11.68 -0.54 1.18e-26 Colorectal cancer; LUSC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6840360 0.582 rs1372976 chr4:152451453 G/A cg20465933 chr4:152376761 FAM160A1 0.33 5.94 0.31 7.19e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.78 -9.98 -0.48 1.07e-20 Gut microbiome composition (summer); LUSC trans rs3733585 0.699 rs4276278 chr4:9948870 T/C cg26043149 chr18:55253948 FECH -0.44 -6.81 -0.35 4.65e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg27094323 chr7:1216898 NA -0.35 -6.07 -0.32 3.49e-9 Longevity;Endometriosis; LUSC cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg15997130 chr1:24165203 NA 0.52 8.53 0.42 5.25e-16 Immature fraction of reticulocytes; LUSC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs136211 0.640 rs9610495 chr22:36760838 G/A cg21778268 chr22:36877729 TXN2 -0.41 -5.79 -0.3 1.64e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg09839279 chr12:125627357 AACS -0.34 -5.89 -0.31 9.5e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs367943 1.000 rs348955 chr5:112821643 C/T cg12552261 chr5:112820674 MCC -0.44 -7.01 -0.36 1.3e-11 Type 2 diabetes; LUSC cis rs1832871 1.000 rs827858 chr6:158707396 T/C cg07165851 chr6:158734300 TULP4 0.37 6.5 0.33 2.99e-10 Height; LUSC cis rs11676348 0.783 rs13035513 chr2:218960680 C/T cg06547715 chr2:218990976 CXCR2 0.34 6.5 0.34 2.93e-10 Ulcerative colitis; LUSC cis rs10927875 0.619 rs7546589 chr1:16129530 A/G cg21385522 chr1:16154831 NA -0.6 -9.74 -0.47 6.69e-20 Dilated cardiomyopathy; LUSC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg15556689 chr8:8085844 FLJ10661 0.66 10.83 0.51 1.3e-23 Mood instability; LUSC cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC cis rs11098499 0.535 rs7671759 chr4:120248094 A/C cg24375607 chr4:120327624 NA 0.75 11.65 0.54 1.43e-26 Corneal astigmatism; LUSC cis rs61931739 0.929 rs1490110 chr12:34091605 A/G cg06521331 chr12:34319734 NA 0.38 6.47 0.33 3.55e-10 Morning vs. evening chronotype; LUSC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg02782426 chr3:40428986 ENTPD3 0.41 7.8 0.39 8.21e-14 Renal cell carcinoma; LUSC cis rs9796 0.835 rs11856848 chr15:41370961 C/T cg18705301 chr15:41695430 NDUFAF1 -0.46 -8.04 -0.4 1.55e-14 Menopause (age at onset); LUSC cis rs9420 0.961 rs12805841 chr11:57443842 G/A cg02958346 chr11:57425731 CLP1 -0.44 -6.45 -0.33 4.02e-10 Schizophrenia; LUSC cis rs859767 0.741 rs6430529 chr2:135433023 G/T cg12500956 chr2:135428796 TMEM163 -0.29 -6.49 -0.33 3.19e-10 Neuroticism; LUSC cis rs983392 1.000 rs920573 chr11:59924959 G/A cg24026212 chr11:59952134 MS4A6A -0.33 -5.65 -0.3 3.42e-8 Alzheimer's disease (late onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09828504 chr21:43279690 PRDM15 -0.4 -6.78 -0.35 5.5e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7043114 0.544 rs4302908 chr9:95321641 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.55 -0.34 2.14e-10 Height; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg00945038 chr17:61921165 SMARCD2 -0.53 -9.31 -0.45 1.73e-18 Prudent dietary pattern; LUSC cis rs9486719 1.000 rs6921291 chr6:97066242 C/T cg06623918 chr6:96969491 KIAA0776 -0.79 -9.6 -0.47 1.95e-19 Migraine;Coronary artery disease; LUSC cis rs9660992 1.000 rs1779410 chr1:205248759 A/G cg00857998 chr1:205179979 DSTYK 0.44 6.6 0.34 1.61e-10 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10751667 0.643 rs7396623 chr11:934104 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.38 0.33 6.06e-10 Alzheimer's disease (late onset); LUSC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg27494647 chr7:150038898 RARRES2 -0.57 -8.43 -0.42 1.04e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs77106637 0.556 rs7123876 chr11:72444583 T/C cg03713592 chr11:72463424 ARAP1 0.59 7.66 0.39 1.96e-13 Type 2 diabetes; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg10346511 chr11:30344563 C11orf46 0.42 6.21 0.32 1.61e-9 Mosquito bite size; LUSC cis rs34779708 0.931 rs34304999 chr10:35365705 C/T cg04310649 chr10:35416472 CREM -0.4 -6.18 -0.32 1.83e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg02569458 chr12:86230093 RASSF9 0.52 8.36 0.42 1.67e-15 Major depressive disorder; LUSC cis rs1372520 0.684 rs2737030 chr4:90710099 C/T cg15133208 chr4:90757351 SNCA -0.55 -8.29 -0.41 2.77e-15 Neuroticism; LUSC cis rs2274273 1.000 rs66871576 chr14:55629050 C/T cg04306507 chr14:55594613 LGALS3 0.55 12.02 0.55 6.51e-28 Protein biomarker; LUSC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg21385522 chr1:16154831 NA 0.69 10.34 0.49 6.47e-22 Dilated cardiomyopathy; LUSC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg04352962 chr1:209979756 IRF6 0.5 6.78 0.35 5.51e-11 Cleft lip with or without cleft palate; LUSC cis rs34779708 0.931 rs35388511 chr10:35296616 A/G cg04310649 chr10:35416472 CREM -0.4 -6.19 -0.32 1.72e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg25233709 chr10:116636983 FAM160B1 0.44 7.89 0.4 4.28e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs34172651 0.917 rs2112786 chr16:24778944 C/T cg06028605 chr16:24865363 SLC5A11 0.46 8.43 0.42 1.06e-15 Intelligence (multi-trait analysis); LUSC trans rs3942852 0.568 rs10838800 chr11:48094879 C/T cg15704280 chr7:45808275 SEPT13 -0.62 -8.09 -0.4 1.09e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7940866 0.646 rs10894293 chr11:130824213 C/T cg12179176 chr11:130786555 SNX19 -0.58 -8.89 -0.44 3.88e-17 Schizophrenia; LUSC cis rs7215564 0.908 rs4243241 chr17:78660502 A/C cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs7089973 0.668 rs7898347 chr10:116644324 G/A cg03647239 chr10:116582469 FAM160B1 0.42 6.34 0.33 7.32e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg04287289 chr16:89883240 FANCA -0.41 -6.0 -0.31 5.16e-9 Vitiligo; LUSC cis rs11645898 1.000 rs72791117 chr16:72217385 T/C cg14768367 chr16:72042858 DHODH -0.55 -5.96 -0.31 6.48e-9 Blood protein levels; LUSC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg07640336 chr12:132677496 NA 0.43 8.54 0.42 4.99e-16 Anti-saccade response; LUSC cis rs16917546 0.967 rs10995239 chr10:64388365 A/G cg03961010 chr10:64397487 ZNF365 -0.42 -6.66 -0.34 1.1e-10 Basal cell carcinoma; LUSC cis rs2011503 0.883 rs17216041 chr19:19366643 C/T cg11584989 chr19:19387371 SF4 0.62 7.5 0.38 5.74e-13 Bipolar disorder; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg12582022 chr3:112738401 C3orf17 0.52 6.63 0.34 1.33e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.55 5.78 0.3 1.74e-8 Cerebrospinal P-tau181p levels; LUSC cis rs7216064 1.000 rs8067892 chr17:65837983 A/G cg12091567 chr17:66097778 LOC651250 -0.73 -9.44 -0.46 6.6e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs3847153 1.000 rs36061340 chr8:101807230 C/T cg05884214 chr7:1712054 NA 0.63 5.99 0.31 5.4e-9 Premature ovarian failure; LUSC cis rs3768617 0.868 rs20561 chr1:183105705 G/A ch.1.3577855R chr1:183094577 LAMC1 0.58 8.15 0.41 7.15e-15 Fuchs's corneal dystrophy; LUSC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.76e-13 Schizophrenia; LUSC trans rs877282 0.853 rs7079450 chr10:755932 T/A cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs7075426 0.524 rs12411744 chr10:88245075 G/A cg07322936 chr10:88137208 NA 0.42 6.02 0.31 4.49e-9 Migraine without aura; LUSC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg05313129 chr8:58192883 C8orf71 -0.55 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs4319547 0.695 rs11836188 chr12:122865507 T/C cg05707623 chr12:122985044 ZCCHC8 0.66 8.11 0.41 9.63e-15 Body mass index; LUSC trans rs877282 1.000 rs11253361 chr10:770387 T/C cg22713356 chr15:30763199 NA 1.06 15.09 0.64 1.33e-39 Uric acid levels; LUSC cis rs1801251 0.778 rs709934 chr2:233733352 A/G cg08000102 chr2:233561755 GIGYF2 -0.52 -8.17 -0.41 6.48e-15 Coronary artery disease; LUSC cis rs6700896 0.966 rs10889570 chr1:66088084 C/G cg04111102 chr1:66153794 NA 0.32 7.05 0.36 1.03e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.61 0.54 2.12e-26 Alzheimer's disease; LUSC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg25019033 chr10:957182 NA -0.5 -6.26 -0.32 1.18e-9 Eosinophil percentage of granulocytes; LUSC cis rs7527798 1.000 rs2147021 chr1:207849214 A/G cg09232269 chr1:207846808 CR1L -0.32 -5.83 -0.3 1.3e-8 Erythrocyte sedimentation rate; LUSC trans rs9650657 0.506 rs7823296 chr8:10778546 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.22 -0.37 3.64e-12 Neuroticism; LUSC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg18404041 chr3:52824283 ITIH1 -0.5 -9.53 -0.46 3.33e-19 Bipolar disorder; LUSC cis rs4986172 0.726 rs12051846 chr17:43226887 A/G cg10701640 chr17:43249399 NA 0.47 10.0 0.48 8.96e-21 Height; LUSC cis rs4499344 0.633 rs259256 chr19:33151802 C/T cg22980127 chr19:33182716 NUDT19 -0.44 -6.51 -0.34 2.74e-10 Mean platelet volume; LUSC cis rs7267979 1.000 rs6050599 chr20:25400240 T/C cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg14895029 chr7:2775587 GNA12 -0.4 -6.06 -0.31 3.61e-9 Height; LUSC cis rs3020736 0.500 rs6002623 chr22:42513761 G/A cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg24060327 chr5:131705240 SLC22A5 -0.67 -11.48 -0.53 6.2e-26 Acylcarnitine levels; LUSC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.52 0.34 2.54e-10 Schizophrenia; LUSC cis rs6964587 1.000 rs9690208 chr7:91735613 T/A cg01689657 chr7:91764605 CYP51A1 0.33 6.08 0.32 3.34e-9 Breast cancer; LUSC cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg05347473 chr6:146136440 FBXO30 0.54 9.27 0.45 2.43e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg20503657 chr10:835505 NA 0.99 13.96 0.61 3.29e-35 Eosinophil percentage of granulocytes; LUSC cis rs10203711 1.000 rs6711116 chr2:239596636 T/G cg14580085 chr2:239553406 NA 0.42 7.06 0.36 9.66e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1348850 0.914 rs2121430 chr2:178318375 A/G cg22681709 chr2:178499509 PDE11A -0.48 -8.74 -0.43 1.15e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs8177253 0.511 rs9830001 chr3:133433470 A/G cg01448562 chr3:133502909 NA 0.44 6.95 0.36 1.92e-11 Iron status biomarkers; LUSC cis rs61931739 0.500 rs7979769 chr12:34509522 C/T cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.57e-10 Morning vs. evening chronotype; LUSC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg18230493 chr5:56204884 C5orf35 -0.55 -8.7 -0.43 1.59e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs34779708 0.931 rs11010082 chr10:35351155 A/G cg04310649 chr10:35416472 CREM -0.41 -6.43 -0.33 4.53e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1005224 1.000 rs1158282 chr14:76172916 C/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.54 -7.14 -0.36 5.98e-12 Large artery stroke; LUSC cis rs11018904 0.636 rs61903695 chr11:89922417 A/G cg26028595 chr11:89956573 CHORDC1 -0.47 -5.76 -0.3 1.9e-8 Intelligence (multi-trait analysis); LUSC cis rs151234 0.741 rs151230 chr16:28583215 G/A cg01378222 chr16:28622494 SULT1A1 -0.62 -8.34 -0.42 1.95e-15 Platelet distribution width; LUSC cis rs6500395 1.000 rs11647048 chr16:48623227 T/G cg04672837 chr16:48644449 N4BP1 0.49 7.02 0.36 1.26e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.51 -7.63 -0.39 2.51e-13 Menarche (age at onset); LUSC cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg04450456 chr4:17643702 FAM184B 0.35 6.01 0.31 4.76e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12367572 1.000 rs7304472 chr12:45262324 A/G cg04608330 chr12:45269318 NELL2 -0.59 -9.48 -0.46 4.74e-19 Gut microbiome composition (summer); LUSC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs7617480 0.648 rs9859473 chr3:48837182 A/G cg21141812 chr3:48556323 PFKFB4 0.33 5.94 0.31 7.06e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs2404602 0.692 rs57178708 chr15:76904069 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.81 -0.39 7.64e-14 Blood metabolite levels; LUSC cis rs7246657 1.000 rs1529957 chr19:37739801 A/G cg23950597 chr19:37808831 NA -0.62 -7.32 -0.37 1.89e-12 Coronary artery calcification; LUSC cis rs9905704 0.627 rs1267544 chr17:56643398 T/G cg12560992 chr17:57184187 TRIM37 -0.53 -6.34 -0.33 7.56e-10 Testicular germ cell tumor; LUSC trans rs10090774 0.965 rs13255947 chr8:141911445 T/C cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 6.08 0.32 3.28e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs61931739 0.534 rs1486886 chr12:34043619 C/T cg13010199 chr12:38710504 ALG10B 0.53 7.92 0.4 3.45e-14 Morning vs. evening chronotype; LUSC cis rs6696846 0.715 rs12139373 chr1:205054879 A/C cg21643547 chr1:205240462 TMCC2 -0.42 -7.58 -0.38 3.47e-13 Red blood cell count; LUSC cis rs7666738 0.712 rs11731393 chr4:98859070 G/C cg05340658 chr4:99064831 C4orf37 0.58 7.74 0.39 1.2e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg00343986 chr7:65444356 GUSB -0.48 -7.28 -0.37 2.37e-12 Aortic root size; LUSC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.98e-11 Blood metabolite levels; LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 13.5 0.59 1.97e-33 Platelet count; LUSC trans rs7726839 0.507 rs60068988 chr5:597668 T/C cg25482853 chr8:67687455 SGK3 1.12 15.85 0.66 1.36e-42 Obesity-related traits; LUSC cis rs9326248 0.559 rs10892064 chr11:116896553 G/C cg20608306 chr11:116969690 SIK3 0.37 6.97 0.36 1.73e-11 Blood protein levels; LUSC cis rs7829975 0.774 rs1039915 chr8:8679614 T/C cg06636001 chr8:8085503 FLJ10661 0.6 9.1 0.45 8.61e-18 Mood instability; LUSC cis rs9300255 0.510 rs1790086 chr12:123672518 A/G cg05973401 chr12:123451056 ABCB9 0.53 6.54 0.34 2.29e-10 Neutrophil percentage of white cells; LUSC cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg06784218 chr1:46089804 CCDC17 0.51 10.18 0.49 2.28e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs11250098 0.583 rs66724331 chr8:10789345 C/A cg15556689 chr8:8085844 FLJ10661 -0.56 -7.95 -0.4 2.84e-14 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg19077165 chr18:44547161 KATNAL2 0.42 6.41 0.33 4.9e-10 Personality dimensions; LUSC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs7267979 1.000 rs7343481 chr20:25300113 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.71e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7267979 0.789 rs9927 chr20:25277244 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 16.91 0.68 8.92e-47 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7819412 0.669 rs6601568 chr8:11073402 G/A cg21775007 chr8:11205619 TDH -0.57 -8.03 -0.4 1.66e-14 Triglycerides; LUSC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg02269571 chr22:50332266 NA -0.54 -8.0 -0.4 2.09e-14 Schizophrenia; LUSC trans rs4729127 1.000 rs7799378 chr7:94007546 C/G cg19987288 chr12:56122958 CD63 -0.52 -6.03 -0.31 4.31e-9 Intelligence; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg26354017 chr1:205819088 PM20D1 -0.78 -15.15 -0.64 8.11e-40 Monocyte percentage of white cells; LUSC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg20891283 chr12:69753455 YEATS4 0.82 15.09 0.64 1.34e-39 Blood protein levels; LUSC cis rs2857891 0.695 rs2857893 chr11:6983330 C/T cg04053776 chr11:6947353 ZNF215 0.4 5.94 0.31 7.14e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg21016266 chr12:122356598 WDR66 -0.6 -9.23 -0.45 3.1e-18 Mean corpuscular volume; LUSC cis rs9929218 0.953 rs9927329 chr16:68750331 C/T cg02972257 chr16:68554789 NA 0.45 5.96 0.31 6.47e-9 Colorectal cancer; LUSC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg03526776 chr6:41159608 TREML2 0.33 6.44 0.33 4.24e-10 Alzheimer's disease (late onset); LUSC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg03233332 chr7:66118400 NA 0.41 6.0 0.31 5.17e-9 Aortic root size; LUSC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg19230755 chr7:65878503 NA -0.41 -5.71 -0.3 2.5e-8 Aortic root size; LUSC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs272594 1.000 rs272595 chr8:81470769 A/G cg01004056 chr1:230560318 NA -0.43 -5.97 -0.31 6.16e-9 Neutrophil count; LUSC cis rs10791097 0.728 rs10894265 chr11:130714613 T/C cg12179176 chr11:130786555 SNX19 -0.67 -10.07 -0.48 5.46e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg14552801 chr7:65878734 NA 0.39 6.07 0.32 3.53e-9 Aortic root size; LUSC cis rs76878669 0.561 rs7115577 chr11:66172258 G/T cg24851651 chr11:66362959 CCS 0.39 6.13 0.32 2.43e-9 Educational attainment (years of education); LUSC cis rs2625529 0.824 rs7170461 chr15:72218599 C/A cg16672083 chr15:72433130 SENP8 -0.52 -7.51 -0.38 5.28e-13 Red blood cell count; LUSC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg23630131 chr7:65973040 NA -0.2 -5.64 -0.3 3.55e-8 Aortic root size; LUSC cis rs7589342 0.501 rs12995849 chr2:106443111 C/T cg14210321 chr2:106509881 NCK2 -0.4 -6.0 -0.31 5.23e-9 Addiction; LUSC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg06618935 chr21:46677482 NA -0.42 -7.94 -0.4 3.02e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7432375 0.610 rs6793936 chr3:136509793 A/C cg12473912 chr3:136751656 NA 0.32 5.7 0.3 2.59e-8 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs2285002 0.745 rs229674 chr14:65281472 G/C cg01253149 chr3:184321996 NA -0.32 -6.23 -0.32 1.39e-9 Red cell distribution width; LUSC cis rs3806843 1.000 rs3733710 chr5:140167463 C/T cg19875535 chr5:140030758 IK 0.5 8.24 0.41 3.98e-15 Depressive symptoms (multi-trait analysis); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg16605590 chr2:122494233 MKI67IP 0.42 6.45 0.33 3.91e-10 N-glycan levels; LUSC cis rs7178572 0.962 rs12324627 chr15:77767539 A/G cg22256960 chr15:77711686 NA -0.55 -9.2 -0.45 4.07e-18 Type 2 diabetes; LUSC cis rs1797081 0.967 rs780632 chr10:16861400 A/G cg23933602 chr10:16859644 RSU1 -1.03 -22.33 -0.77 3.09e-68 Platelet distribution width; LUSC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg27266027 chr21:40555129 PSMG1 0.42 6.17 0.32 1.99e-9 Cognitive function; LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.96e-15 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg05025164 chr4:1340916 KIAA1530 0.46 7.07 0.36 9.08e-12 Obesity-related traits; LUSC cis rs6940638 0.688 rs9461335 chr6:27138529 C/A cg05738196 chr6:26577821 NA -0.48 -6.89 -0.35 2.74e-11 Intelligence (multi-trait analysis); LUSC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg08923669 chr16:420230 MRPL28 -0.48 -7.89 -0.4 4.38e-14 Bone mineral density (spine);Bone mineral density; LUSC cis rs9400467 0.528 rs462432 chr6:111659755 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.85 -0.35 3.51e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs4665630 0.522 rs2712054 chr2:23956123 C/T cg08063864 chr2:24346004 PFN4;LOC375190 0.78 7.38 0.37 1.29e-12 Hypertension; LUSC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg08439880 chr3:133502540 NA -0.31 -5.82 -0.3 1.4e-8 Iron status biomarkers; LUSC trans rs1547374 0.694 rs225349 chr21:43776890 C/T cg09521743 chr10:75415752 SYNPO2L 0.5 9.07 0.44 1.03e-17 Pancreatic cancer; LUSC cis rs9650657 0.601 rs10903330 chr8:10673104 C/T cg27411982 chr8:10470053 RP1L1 0.35 5.69 0.3 2.78e-8 Neuroticism; LUSC trans rs7829975 0.623 rs10092965 chr8:8373485 A/G cg27411982 chr8:10470053 RP1L1 0.41 6.63 0.34 1.33e-10 Mood instability; LUSC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg12311346 chr5:56204834 C5orf35 -1.01 -14.65 -0.63 7.19e-38 Initial pursuit acceleration; LUSC cis rs6541297 0.941 rs2144299 chr1:230280366 A/G cg20703242 chr1:230279135 GALNT2 0.61 8.48 0.42 7.51e-16 Coronary artery disease; LUSC cis rs10465746 0.780 rs2389649 chr1:84379449 C/T cg10977910 chr1:84465055 TTLL7 0.45 6.41 0.33 4.94e-10 Obesity-related traits; LUSC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.63 -0.43 2.55e-16 Gut microbiome composition (summer); LUSC cis rs9309473 1.000 rs1881245 chr2:73649928 G/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.35 -0.33 6.83e-10 Metabolite levels; LUSC cis rs56804039 1.000 rs7017341 chr8:8381664 C/A cg15556689 chr8:8085844 FLJ10661 -0.56 -6.99 -0.36 1.54e-11 Cervical cancer; LUSC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs8073060 0.572 rs1634683 chr17:33941560 G/C cg19694781 chr19:47549865 TMEM160 -1.12 -17.84 -0.7 1.74e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs250677 0.522 rs998304 chr5:148382365 C/A cg18129178 chr5:148520854 ABLIM3 -0.51 -7.4 -0.38 1.11e-12 Breast cancer; LUSC cis rs9323205 0.723 rs55980461 chr14:51737434 G/A cg23942311 chr14:51606299 NA -0.42 -7.95 -0.4 2.83e-14 Cancer; LUSC cis rs679087 0.640 rs79708380 chr12:29909457 G/A cg14258853 chr12:29935411 TMTC1 -1.01 -15.0 -0.63 2.92e-39 Schizophrenia; LUSC trans rs877282 0.853 rs10904544 chr10:756966 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.48 -0.33 3.21e-10 Uric acid levels; LUSC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.63 9.62 0.47 1.65e-19 Height; LUSC cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14240646 chr10:27532245 ACBD5 0.71 8.19 0.41 5.71e-15 Breast cancer; LUSC cis rs6740322 0.948 rs6722694 chr2:43569798 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.44 -6.19 -0.32 1.79e-9 Coronary artery disease; LUSC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg16680214 chr1:154839983 KCNN3 -0.56 -10.92 -0.51 6.29e-24 Prostate cancer; LUSC cis rs929354 0.742 rs7807556 chr7:156934329 T/C cg05182265 chr7:156933206 UBE3C -0.6 -9.62 -0.47 1.68e-19 Body mass index; LUSC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.68 -8.56 -0.42 4.17e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs6598955 0.724 rs7526545 chr1:26569990 C/A cg00852783 chr1:26633632 UBXN11 0.49 8.74 0.43 1.17e-16 Obesity-related traits; LUSC cis rs4356932 1.000 rs6850760 chr4:76951684 A/T cg00809888 chr4:76862425 NAAA 0.38 6.42 0.33 4.72e-10 Blood protein levels; LUSC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.66 10.48 0.5 2.16e-22 Cognitive test performance; LUSC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg05585544 chr11:47624801 NA -0.42 -7.26 -0.37 2.74e-12 Subjective well-being; LUSC trans rs8073060 0.586 rs225280 chr17:33976296 C/T cg19694781 chr19:47549865 TMEM160 -1.14 -17.81 -0.7 2.27e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1941023 0.584 rs2241920 chr11:60164204 A/G cg08716584 chr11:60157161 MS4A7 0.6 10.63 0.5 6.06e-23 Congenital heart disease (maternal effect); LUSC cis rs12410462 0.581 rs7543931 chr1:227550976 A/T cg10327440 chr1:227177885 CDC42BPA -0.67 -6.43 -0.33 4.5e-10 Major depressive disorder; LUSC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg23625390 chr15:77176239 SCAPER 0.59 9.22 0.45 3.51e-18 Blood metabolite levels; LUSC cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg05340658 chr4:99064831 C4orf37 0.68 11.71 0.54 8.87e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg04414720 chr1:150670196 GOLPH3L 0.52 8.31 0.41 2.42e-15 Melanoma; LUSC cis rs6840360 0.615 rs6535816 chr4:152614264 T/C cg22705602 chr4:152727874 NA -0.35 -7.48 -0.38 6.81e-13 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17436476 chr1:62120002 NA 0.5 5.95 0.31 6.71e-9 Bipolar disorder and schizophrenia; LUSC trans rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05039488 chr6:79577232 IRAK1BP1 0.46 7.12 0.36 6.84e-12 Endometrial cancer; LUSC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.81 -0.39 7.53e-14 Intelligence (multi-trait analysis); LUSC trans rs2243480 1.000 rs7456042 chr7:65299778 T/C cg10756647 chr7:56101905 PSPH 0.87 8.4 0.42 1.31e-15 Diabetic kidney disease; LUSC cis rs6690583 0.623 rs7522239 chr1:85484366 C/T cg22153463 chr1:85462885 MCOLN2 0.6 5.96 0.31 6.35e-9 Serum sulfate level; LUSC cis rs1153858 1.000 rs1618874 chr15:45622786 A/G cg26924012 chr15:45694286 SPATA5L1 1.13 19.81 0.73 2.73e-58 Homoarginine levels; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg04141948 chr7:1023156 CYP2W1 0.3 6.26 0.32 1.2e-9 Longevity;Endometriosis; LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs3931020 0.657 rs277376 chr1:75242246 G/T cg00121533 chr1:75199117 CRYZ;TYW3 -0.45 -5.77 -0.3 1.78e-8 Resistin levels; LUSC cis rs8017423 0.967 rs11626011 chr14:90693572 A/G cg14092571 chr14:90743983 NA -0.37 -6.16 -0.32 2.07e-9 Mortality in heart failure; LUSC cis rs2014572 0.967 rs7248000 chr19:57762139 C/T cg24459738 chr19:57751996 ZNF805 -0.5 -7.35 -0.37 1.56e-12 Hyperactive-impulsive symptoms; LUSC cis rs909341 0.710 rs3848669 chr20:62300811 G/T cg09650180 chr20:62225654 GMEB2 0.46 5.97 0.31 6.2e-9 Atopic dermatitis; LUSC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg19912559 chr1:40204330 PPIE 0.53 8.18 0.41 6.17e-15 Blood protein levels; LUSC cis rs1865760 0.566 rs9467672 chr6:26083904 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg22823121 chr1:150693482 HORMAD1 0.48 6.92 0.35 2.26e-11 Melanoma; LUSC cis rs12681287 0.604 rs6471316 chr8:87403587 G/C cg27223183 chr8:87520930 FAM82B 0.55 7.45 0.38 8.05e-13 Caudate activity during reward; LUSC cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg23093090 chr10:104574429 C10orf26 -0.37 -6.87 -0.35 3.08e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.56 9.53 0.46 3.4e-19 IgG glycosylation; LUSC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg02423579 chr7:2872169 GNA12 -0.45 -6.35 -0.33 6.84e-10 Height; LUSC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs4919694 1.000 rs12252500 chr10:104794984 G/C cg23093090 chr10:104574429 C10orf26 -0.47 -5.76 -0.3 1.94e-8 Arsenic metabolism; LUSC cis rs9653442 0.545 rs11123813 chr2:100765692 C/T cg07810366 chr2:100720526 AFF3 -0.45 -7.79 -0.39 8.8e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7580658 0.864 rs4150441 chr2:128040915 T/C cg09760422 chr2:128146352 NA -0.28 -5.89 -0.31 9.64e-9 Protein C levels; LUSC cis rs6484504 0.512 rs7940020 chr11:31366453 T/G cg06552810 chr11:31128660 NA 0.39 6.68 0.34 1.02e-10 Red blood cell count; LUSC cis rs7267979 1.000 rs6083804 chr20:25317060 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.71e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2046867 0.862 rs6788139 chr3:72835630 A/G cg25664220 chr3:72788482 NA 0.61 9.82 0.47 3.8e-20 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs477692 0.905 rs4751106 chr10:131424653 G/T cg05714579 chr10:131428358 MGMT -0.52 -7.97 -0.4 2.45e-14 Response to temozolomide; LUSC cis rs2898290 0.506 rs2736311 chr8:11252170 C/T cg21775007 chr8:11205619 TDH -0.59 -9.34 -0.45 1.42e-18 Systolic blood pressure; LUSC cis rs2579519 0.547 rs2463560 chr2:96595589 T/C cg23100626 chr2:96804247 ASTL 0.23 5.75 0.3 2.05e-8 Diastolic blood pressure; LUSC cis rs1775715 0.707 rs2808088 chr10:32146150 A/G cg03015672 chr10:32216066 ARHGAP12 0.35 6.39 0.33 5.5e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1014246 1.000 rs2240706 chr10:118466297 C/G cg14919929 chr10:118506882 NA 0.38 5.88 0.31 9.98e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs4253772 0.938 rs41355347 chr22:46637511 G/A cg09491104 chr22:46646882 C22orf40 -0.64 -6.59 -0.34 1.75e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs7937682 0.575 rs7950926 chr11:111776437 G/C cg22437258 chr11:111473054 SIK2 -0.45 -5.96 -0.31 6.25e-9 Primary sclerosing cholangitis; LUSC cis rs3862435 0.706 rs2253425 chr15:90945759 G/A cg22089800 chr15:90895588 ZNF774 0.55 5.96 0.31 6.34e-9 Response to exercise (triglyceride level interaction); LUSC cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg08213375 chr14:104286397 PPP1R13B 0.52 10.25 0.49 1.29e-21 Schizophrenia; LUSC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg14983838 chr19:29218262 NA 0.65 9.48 0.46 5e-19 Methadone dose in opioid dependence; LUSC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg03351412 chr1:154909251 PMVK 0.5 7.91 0.4 3.85e-14 Prostate cancer; LUSC cis rs826838 0.616 rs9668847 chr12:38614669 C/T cg13010199 chr12:38710504 ALG10B 0.48 7.28 0.37 2.47e-12 Heart rate; LUSC trans rs629535 0.862 rs654604 chr8:70048939 C/A cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs7772486 0.875 rs6909827 chr6:146365738 A/G cg23711669 chr6:146136114 FBXO30 0.85 15.26 0.64 2.8e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg07701084 chr6:150067640 NUP43 0.53 7.99 0.4 2.25e-14 Lung cancer; LUSC cis rs10484885 0.824 rs72919954 chr6:90515665 T/A cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.06 -0.4 1.35e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg17294928 chr15:75287854 SCAMP5 -0.76 -10.18 -0.49 2.18e-21 Blood trace element (Zn levels); LUSC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg27432699 chr2:27873401 GPN1 -0.58 -8.68 -0.43 1.72e-16 Total body bone mineral density; LUSC cis rs1662342 1.000 rs1662343 chr18:3251994 A/G cg00760847 chr18:3262519 MYL12B -0.58 -5.68 -0.3 2.97e-8 QRS duration; LUSC cis rs6500602 0.727 rs12443748 chr16:4541831 C/T cg08645402 chr16:4508243 NA 0.49 8.11 0.41 9.74e-15 Schizophrenia; LUSC cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg14844989 chr11:31128820 NA -0.39 -5.93 -0.31 7.53e-9 Red blood cell count; LUSC cis rs6920965 0.507 rs9385389 chr6:126215486 G/C cg05901451 chr6:126070800 HEY2 -0.53 -7.62 -0.38 2.66e-13 High light scatter reticulocyte count; LUSC cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.8 -0.54 4.37e-27 Chronic sinus infection; LUSC cis rs1577917 1.000 rs4707239 chr6:86610717 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs11039100 0.607 rs34670757 chr11:5783042 G/C cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs865483 0.860 rs2522968 chr17:35830300 G/A cg06716730 chr17:35851459 DUSP14 0.28 6.18 0.32 1.91e-9 Monocyte count; LUSC cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg23583168 chr7:148888333 NA -0.9 -16.73 -0.68 4.51e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg10802521 chr3:52805072 NEK4 -0.54 -8.59 -0.43 3.47e-16 Bipolar disorder; LUSC cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg22906224 chr7:99728672 NA 0.52 7.57 0.38 3.71e-13 Coronary artery disease; LUSC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg13206674 chr6:150067644 NUP43 0.57 8.9 0.44 3.71e-17 Lung cancer; LUSC cis rs9487051 0.703 rs351755 chr6:109538073 G/A cg01475377 chr6:109611718 NA 0.35 6.03 0.31 4.42e-9 Reticulocyte fraction of red cells; LUSC trans rs2243480 0.908 rs2460431 chr7:65622846 A/G cg10756647 chr7:56101905 PSPH -0.84 -8.39 -0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.7 -0.3 2.59e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs9457247 0.967 rs1794696 chr6:167396174 T/C cg25258033 chr6:167368657 RNASET2 0.49 8.04 0.4 1.62e-14 Crohn's disease; LUSC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg16414030 chr3:133502952 NA -0.39 -5.85 -0.3 1.17e-8 Iron status biomarkers; LUSC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg04455712 chr21:45112962 RRP1B 0.44 8.36 0.42 1.66e-15 Mean corpuscular volume; LUSC cis rs7267979 1.000 rs6115191 chr20:25440478 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.22 0.71 5.32e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9325144 0.560 rs1601745 chr12:38647828 G/A cg13010199 chr12:38710504 ALG10B -0.53 -8.1 -0.41 1.03e-14 Morning vs. evening chronotype; LUSC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg15485101 chr11:133734466 NA 0.43 7.61 0.38 2.75e-13 Childhood ear infection; LUSC cis rs1256061 0.654 rs1256040 chr14:64738394 G/A cg21174375 chr14:64681225 SYNE2 0.33 6.04 0.31 4.05e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1997103 0.871 rs6956733 chr7:55393032 A/C cg17469321 chr7:55412551 NA 0.65 9.62 0.47 1.69e-19 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg20203395 chr5:56204925 C5orf35 -0.67 -8.75 -0.43 1.08e-16 Initial pursuit acceleration; LUSC cis rs1595825 0.627 rs1435567 chr2:198748726 T/C cg00982548 chr2:198649783 BOLL -0.56 -7.07 -0.36 9.04e-12 Ulcerative colitis; LUSC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg07701084 chr6:150067640 NUP43 0.51 7.64 0.39 2.37e-13 Lung cancer; LUSC cis rs7312933 0.703 rs7957471 chr12:42545591 G/T cg01256987 chr12:42539512 GXYLT1 -0.44 -8.08 -0.4 1.19e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9796 0.621 rs11858678 chr15:41467932 A/G cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.51 -0.42 5.95e-16 Menopause (age at onset); LUSC cis rs11098499 0.909 rs35165976 chr4:120325630 G/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC trans rs6600671 0.966 rs6600664 chr1:121222436 G/A cg00646200 chr1:148855367 NA 0.46 7.12 0.36 6.57e-12 Hip geometry; LUSC cis rs6580649 0.598 rs1793913 chr12:48387025 T/A cg24011408 chr12:48396354 COL2A1 0.5 6.36 0.33 6.75e-10 Lung cancer; LUSC cis rs7666738 0.546 rs11727151 chr4:98837353 A/C cg17366294 chr4:99064904 C4orf37 0.55 8.51 0.42 5.79e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs113835537 0.529 rs11227500 chr11:66273233 T/C cg24851651 chr11:66362959 CCS 0.54 8.14 0.41 7.9e-15 Airway imaging phenotypes; LUSC cis rs28595532 0.623 rs71608363 chr4:119227259 T/C cg21605333 chr4:119757512 SEC24D 0.73 6.13 0.32 2.46e-9 Cannabis dependence symptom count; LUSC trans rs11098499 0.863 rs11736416 chr4:120431661 C/T cg25214090 chr10:38739885 LOC399744 0.5 7.39 0.37 1.19e-12 Corneal astigmatism; LUSC cis rs9486715 0.838 rs6928442 chr6:96870118 A/G cg06623918 chr6:96969491 KIAA0776 0.93 17.58 0.69 1.94e-49 Headache; LUSC cis rs1865760 1.000 rs7770139 chr6:25925823 A/G cg16482183 chr6:26056742 HIST1H1C 0.44 6.56 0.34 2.03e-10 Height; LUSC cis rs68170813 0.559 rs80017637 chr7:107050660 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.36 -0.46 1.25e-18 Coronary artery disease; LUSC cis rs6430585 0.941 rs6708957 chr2:136520043 C/T cg07169764 chr2:136633963 MCM6 0.87 12.05 0.55 4.98e-28 Corneal structure; LUSC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg20639618 chr4:183729073 NA 0.62 8.61 0.43 2.88e-16 Pediatric autoimmune diseases; LUSC cis rs7666738 0.546 rs10007424 chr4:98885450 C/T cg03676636 chr4:99064102 C4orf37 0.31 6.14 0.32 2.39e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs8078723 0.510 rs9898547 chr17:38136026 G/T cg17467752 chr17:38218738 THRA -0.52 -7.69 -0.39 1.63e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.48 9.35 0.46 1.27e-18 Eosinophil percentage of white cells; LUSC cis rs1371867 0.846 rs959022 chr8:101295992 T/A cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.93e-13 Atrioventricular conduction; LUSC cis rs1670533 0.932 rs3796620 chr4:1095079 A/G cg16405210 chr4:1374714 KIAA1530 0.47 5.77 0.3 1.8e-8 Recombination rate (females); LUSC cis rs6736093 0.931 rs34974369 chr2:112683390 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.9 -0.31 8.73e-9 Coronary artery disease; LUSC cis rs1670533 1.000 rs6827357 chr4:1059202 A/C cg02018176 chr4:1364513 KIAA1530 0.43 5.65 0.3 3.45e-8 Recombination rate (females); LUSC cis rs829883 0.646 rs4762494 chr12:98933834 T/G cg25150519 chr12:98850993 NA -0.63 -8.71 -0.43 1.47e-16 Colorectal adenoma (advanced); LUSC cis rs4700695 0.668 rs36837 chr5:65480007 C/A cg21114390 chr5:65439923 SFRS12 -0.51 -7.4 -0.38 1.14e-12 Facial morphology (factor 19); LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg12432903 chr7:1882776 MAD1L1 -0.49 -8.45 -0.42 8.85e-16 Bipolar disorder and schizophrenia; LUSC cis rs7769051 1.000 rs3813347 chr6:133119778 G/A cg22852734 chr6:133119734 C6orf192 1.22 14.16 0.61 5.56e-36 Type 2 diabetes nephropathy; LUSC cis rs4280164 0.887 rs2748543 chr14:24778674 C/A cg16194253 chr14:24768981 DHRS1;C14orf21 -0.61 -7.2 -0.37 4.04e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs208515 0.525 rs10944869 chr6:66687576 G/T cg07460842 chr6:66804631 NA 1.03 14.22 0.61 3.16e-36 Exhaled nitric oxide levels; LUSC trans rs2679649 1.000 rs2679643 chr6:122353149 T/C cg00167820 chr8:131663355 NA 0.54 6.35 0.33 6.96e-10 Subcutaneous adipose tissue; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg10360139 chr7:1886902 MAD1L1 -0.43 -6.46 -0.33 3.79e-10 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1832871 0.541 rs11755760 chr6:158886742 A/G cg07165851 chr6:158734300 TULP4 0.41 5.81 0.3 1.43e-8 Height; LUSC cis rs17401966 1.000 rs6700866 chr1:10306038 A/G cg19773385 chr1:10388646 KIF1B -0.55 -8.69 -0.43 1.6e-16 Hepatocellular carcinoma; LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg07362569 chr17:61921086 SMARCD2 0.37 7.67 0.39 1.92e-13 Prudent dietary pattern; LUSC trans rs75804782 0.581 rs72987336 chr2:239365345 T/C cg01134436 chr17:81009848 B3GNTL1 0.63 6.12 0.32 2.67e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs17253792 0.915 rs28375514 chr14:56179941 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg11764359 chr7:65958608 NA -0.62 -9.4 -0.46 9.28e-19 Corneal structure; LUSC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg21724239 chr8:58056113 NA 0.56 5.97 0.31 5.95e-9 Developmental language disorder (linguistic errors); LUSC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg21782813 chr7:2030301 MAD1L1 0.4 6.54 0.34 2.25e-10 Schizophrenia; LUSC cis rs9393777 0.623 rs56296968 chr6:26474571 C/T cg12826209 chr6:26865740 GUSBL1 0.68 7.67 0.39 1.85e-13 Intelligence (multi-trait analysis); LUSC cis rs11677416 1.000 rs1040193 chr2:113530099 C/T cg27083787 chr2:113543245 IL1A 0.48 7.41 0.38 1.06e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs11098499 0.739 rs9996382 chr4:120151012 C/T cg09307838 chr4:120376055 NA 0.58 8.64 0.43 2.41e-16 Corneal astigmatism; LUSC cis rs7107174 1.000 rs1399196 chr11:78071876 A/G cg02023728 chr11:77925099 USP35 0.46 6.97 0.36 1.71e-11 Testicular germ cell tumor; LUSC cis rs1670533 0.872 rs6854793 chr4:1055768 T/C cg27284194 chr4:1044797 NA 0.6 8.88 0.44 4.09e-17 Recombination rate (females); LUSC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg12463550 chr7:65579703 CRCP -0.42 -6.27 -0.32 1.14e-9 Aortic root size; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg04775059 chr7:64541387 NA 0.48 7.02 0.36 1.24e-11 Calcium levels; LUSC cis rs250677 0.687 rs250672 chr5:148446110 A/G cg23229984 chr5:148520753 ABLIM3 0.41 6.48 0.33 3.22e-10 Breast cancer; LUSC cis rs8072548 1 rs8072548 chr17:38164025 T/G cg17344932 chr17:38183730 MED24;SNORD124 -0.59 -10.47 -0.5 2.34e-22 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg05890377 chr2:74357713 NA 0.73 13.59 0.6 8.73e-34 Gestational age at birth (maternal effect); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04301719 chr15:89164530 AEN 0.7 5.95 0.31 6.74e-9 Cognitive performance; LUSC trans rs2055729 0.645 rs7828229 chr8:9742841 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -6.41 -0.33 5.04e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs1107366 0.513 rs35078897 chr3:125973767 T/C cg01346077 chr3:125931526 NA 0.37 6.37 0.33 6.26e-10 Metabolite levels; LUSC cis rs10088262 0.629 rs7827665 chr8:124804190 G/A cg02993010 chr8:124780839 FAM91A1 -0.47 -5.66 -0.3 3.32e-8 Pancreatic cancer; LUSC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg26695010 chr11:65641043 EFEMP2 -0.48 -7.14 -0.36 6e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs939574 0.790 rs72955440 chr2:220091765 A/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 6.07 0.32 3.4e-9 Platelet distribution width; LUSC cis rs701145 0.938 rs2971446 chr3:154073445 G/C cg17054900 chr3:154042577 DHX36 0.78 7.98 0.4 2.43e-14 Coronary artery disease; LUSC cis rs6121246 0.583 rs28815498 chr20:30351560 T/C cg13852791 chr20:30311386 BCL2L1 0.95 14.9 0.63 7.51e-39 Mean corpuscular hemoglobin; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg04775059 chr7:64541387 NA -0.47 -6.8 -0.35 4.88e-11 Calcium levels; LUSC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg03264133 chr6:25882463 NA -0.44 -7.55 -0.38 4.14e-13 Intelligence (multi-trait analysis); LUSC cis rs1832871 0.711 rs9459946 chr6:158707957 T/C cg07165851 chr6:158734300 TULP4 0.51 7.91 0.4 3.75e-14 Height; LUSC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.84 -0.35 3.89e-11 Developmental language disorder (linguistic errors); LUSC cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg17042849 chr6:26104293 HIST1H4C -0.38 -5.66 -0.3 3.3e-8 Height; LUSC cis rs62103177 0.525 rs612913 chr18:77845882 A/G cg20368463 chr18:77673604 PQLC1 -0.63 -6.72 -0.34 8.05e-11 Opioid sensitivity; LUSC cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs2011503 0.882 rs4808933 chr19:19363812 T/A cg22782873 chr19:19639568 YJEFN3 -0.47 -5.7 -0.3 2.59e-8 Bipolar disorder; LUSC cis rs9467773 1.000 rs1321480 chr6:26532742 A/G cg05738196 chr6:26577821 NA 0.82 15.81 0.65 2e-42 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08135327 chr2:134877962 NA -0.49 -6.66 -0.34 1.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs6754311 0.731 rs687670 chr2:136740900 T/C cg07169764 chr2:136633963 MCM6 0.52 7.21 0.37 3.73e-12 Mosquito bite size; LUSC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg08219700 chr8:58056026 NA 0.51 6.41 0.33 5e-10 Developmental language disorder (linguistic errors); LUSC cis rs6977940 0.558 rs11765473 chr7:2894800 C/G cg19731401 chr7:2775893 GNA12 0.65 7.28 0.37 2.44e-12 White matter integrity; LUSC cis rs9369695 0.842 rs9395262 chr6:47465267 T/C cg12968598 chr6:47444699 CD2AP 0.53 8.0 0.4 2.1e-14 Reticulocyte count; LUSC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg19774624 chr17:42201019 HDAC5 -0.82 -14.27 -0.62 2.15e-36 Total body bone mineral density; LUSC cis rs2224391 0.628 rs9405261 chr6:5249702 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.46 -0.33 3.59e-10 Height; LUSC cis rs2742417 0.603 rs2064064 chr3:45759995 C/T cg10512202 chr3:45649293 LIMD1 0.36 6.04 0.31 4.18e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg23978390 chr7:1156363 C7orf50 0.48 6.79 0.35 5.15e-11 Longevity;Endometriosis; LUSC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg23711669 chr6:146136114 FBXO30 0.91 17.67 0.7 8.33e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.875 rs2777481 chr6:146310036 G/T cg05347473 chr6:146136440 FBXO30 0.52 8.64 0.43 2.32e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg27129171 chr3:47204927 SETD2 0.72 12.66 0.57 2.87e-30 Colorectal cancer; LUSC cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg07817648 chr10:79422355 NA 0.58 7.47 0.38 7.23e-13 Bone mineral density; LUSC cis rs7799006 0.606 rs34417375 chr7:2315105 C/T cg08027265 chr7:2291960 NA -0.62 -10.98 -0.52 3.67e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.54e-8 Menopause (age at onset); LUSC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg03433033 chr1:76189801 ACADM 0.69 9.01 0.44 1.6e-17 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3768617 0.510 rs3765521 chr1:183077615 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.89 0.51 7.97e-24 Fuchs's corneal dystrophy; LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.81e-10 Bipolar disorder; LUSC trans rs2797160 1.000 rs2747722 chr6:126009629 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs1419980 0.673 rs10845432 chr12:7728131 T/C cg25828445 chr12:7781288 NA 0.58 5.97 0.31 6.18e-9 HDL cholesterol levels; LUSC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg02079420 chr8:82753780 SNX16 0.42 7.2 0.37 4.01e-12 Diastolic blood pressure; LUSC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg15445000 chr17:37608096 MED1 0.38 6.53 0.34 2.52e-10 Glomerular filtration rate (creatinine); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03525424 chr17:48238931 NA 0.5 6.68 0.34 1.02e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg08355456 chr11:67383691 NA 0.37 6.83 0.35 4.05e-11 Mean corpuscular volume; LUSC cis rs9549260 0.564 rs7997896 chr13:41268823 T/A cg21288729 chr13:41239152 FOXO1 0.53 7.97 0.4 2.6e-14 Red blood cell count; LUSC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg03732007 chr1:2071316 PRKCZ -0.51 -8.99 -0.44 1.81e-17 Height; LUSC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg17554472 chr22:41940697 POLR3H -0.47 -5.74 -0.3 2.18e-8 Vitiligo; LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 9.93 0.48 1.51e-20 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs73193808 0.639 rs2832237 chr21:30547683 C/G cg03476357 chr21:30257390 N6AMT1 0.47 6.27 0.32 1.13e-9 Coronary artery disease; LUSC cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg25427524 chr10:38739819 LOC399744 0.63 11.19 0.52 6.5e-25 Extrinsic epigenetic age acceleration; LUSC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg23262073 chr20:60523788 NA -0.42 -6.38 -0.33 6.07e-10 Body mass index; LUSC cis rs2798269 1.000 rs2761913 chr13:22135042 A/G cg18095732 chr13:22033692 ZDHHC20 0.41 6.14 0.32 2.29e-9 PR segment; LUSC cis rs8177253 0.632 rs6782523 chr3:133438917 C/T cg11941060 chr3:133502564 NA -0.46 -6.52 -0.34 2.64e-10 Iron status biomarkers; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg26668828 chr6:292823 DUSP22 -0.73 -12.06 -0.55 4.58e-28 Menopause (age at onset); LUSC cis rs738322 0.839 rs133015 chr22:38572526 C/G cg25457927 chr22:38595422 NA -0.44 -9.18 -0.45 4.7e-18 Cutaneous nevi; LUSC cis rs250677 0.958 rs43147 chr5:148417103 C/G cg18129178 chr5:148520854 ABLIM3 0.66 10.27 0.49 1.14e-21 Breast cancer; LUSC cis rs10979 0.964 rs9496683 chr6:143898845 G/A cg25407410 chr6:143891975 LOC285740 -0.75 -11.97 -0.55 1.06e-27 Hypospadias; LUSC cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.76e-11 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg09033563 chr22:24373618 LOC391322 -0.48 -6.78 -0.35 5.33e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg23711669 chr6:146136114 FBXO30 0.87 16.1 0.66 1.44e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9462027 0.606 rs205260 chr6:34563958 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.18 -0.32 1.91e-9 Systemic lupus erythematosus; LUSC trans rs10242455 0.702 rs41385645 chr7:98974038 A/T cg03698393 chr15:89438795 HAPLN3 -0.81 -6.17 -0.32 2e-9 Blood metabolite levels; LUSC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg03647239 chr10:116582469 FAM160B1 0.49 7.97 0.4 2.55e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs7939886 0.920 rs1481926 chr11:55973281 C/T cg15704280 chr7:45808275 SEPT13 0.9 6.77 0.35 5.86e-11 Myopia (pathological); LUSC cis rs1538970 0.884 rs1771551 chr1:45883643 C/G cg05343316 chr1:45956843 TESK2 0.59 8.34 0.42 1.93e-15 Platelet count; LUSC cis rs11864453 0.713 rs7190995 chr16:72124157 A/G cg01557791 chr16:72042693 DHODH -0.52 -7.54 -0.38 4.42e-13 Fibrinogen levels; LUSC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg18402987 chr7:1209562 NA 0.43 5.69 0.3 2.74e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7771547 0.642 rs9470309 chr6:36509751 A/G cg07856975 chr6:36356162 ETV7 0.37 6.42 0.33 4.65e-10 Platelet distribution width; LUSC cis rs459482 1.000 rs464783 chr21:42796480 A/G cg21549285 chr21:42799141 MX1 -0.39 -5.95 -0.31 6.63e-9 IgG glycosylation; LUSC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.87 -0.35 3.19e-11 Intelligence (multi-trait analysis); LUSC cis rs7959452 0.718 rs10878963 chr12:69717166 T/G cg11871910 chr12:69753446 YEATS4 0.55 8.68 0.43 1.78e-16 Blood protein levels; LUSC cis rs1113500 0.730 rs1618693 chr1:108591583 G/A cg06207961 chr1:108661230 NA -0.3 -5.65 -0.3 3.49e-8 Growth-regulated protein alpha levels; LUSC cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg04034577 chr2:241836375 C2orf54 -0.48 -8.89 -0.44 3.77e-17 Urinary metabolites; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg27588902 chr6:42928151 GNMT -0.3 -6.6 -0.34 1.65e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.99 0.31 5.5e-9 Menopause (age at onset); LUSC cis rs9625935 0.700 rs9625921 chr22:30508275 C/G cg11564601 chr22:30592435 NA -0.33 -5.7 -0.3 2.65e-8 Tonsillectomy; LUSC cis rs977987 0.843 rs12443904 chr16:75438770 C/T cg03315344 chr16:75512273 CHST6 0.53 10.17 0.49 2.47e-21 Dupuytren's disease; LUSC cis rs61931739 0.500 rs11052966 chr12:34019826 C/T cg06521331 chr12:34319734 NA -0.5 -8.29 -0.41 2.79e-15 Morning vs. evening chronotype; LUSC trans rs11098499 0.863 rs10009626 chr4:120470005 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.83 0.35 3.91e-11 Corneal astigmatism; LUSC cis rs6547741 1.000 rs1972669 chr2:27767107 T/G cg12559939 chr2:27858050 GPN1 0.41 6.4 0.33 5.27e-10 Oral cavity cancer; LUSC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg07936489 chr17:37558343 FBXL20 -0.72 -9.95 -0.48 1.35e-20 Glomerular filtration rate (creatinine); LUSC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.13e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs13233308 0.837 rs7793933 chr7:87416839 C/T cg22633988 chr4:77610603 SHROOM3 -0.42 -6.3 -0.33 9.27e-10 Schizophrenia; LUSC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs28785552 0.554 rs11084178 chr19:53212361 C/T cg10871876 chr19:53194124 ZNF83 0.36 5.72 0.3 2.31e-8 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs2625529 0.701 rs62025574 chr15:72236075 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.51 -0.38 5.28e-13 Red blood cell count; LUSC trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.21 0.41 4.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs6714788 0.565 rs7558817 chr2:100654482 C/A cg07810366 chr2:100720526 AFF3 -0.39 -6.08 -0.32 3.25e-9 Intelligence (multi-trait analysis); LUSC cis rs4845459 0.967 rs4112787 chr1:152551325 A/G cg08895932 chr1:152778580 LCE1C 0.34 5.78 0.3 1.72e-8 Psoriasis; LUSC cis rs7312933 0.669 rs7974476 chr12:42542484 C/A cg01256987 chr12:42539512 GXYLT1 -0.44 -8.02 -0.4 1.83e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7843479 0.582 rs11135743 chr8:21803008 A/G cg17168535 chr8:21777572 XPO7 0.83 15.48 0.65 3.9e-41 Mean corpuscular volume; LUSC trans rs3857536 0.813 rs4710580 chr6:66935200 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs72781680 0.752 rs56152044 chr2:23927680 A/G cg08917208 chr2:24149416 ATAD2B 1.0 10.21 0.49 1.77e-21 Lymphocyte counts; LUSC cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs894344 0.650 rs16905182 chr8:135576794 C/A cg17885191 chr8:135476712 NA 0.41 5.85 0.3 1.17e-8 Systolic blood pressure; LUSC cis rs6460942 0.591 rs6942551 chr7:12338356 C/T cg06484146 chr7:12443880 VWDE -0.58 -6.2 -0.32 1.64e-9 Coronary artery disease; LUSC cis rs2219968 0.676 rs1586415 chr8:78840220 A/C cg00738934 chr8:78996279 NA -0.35 -5.94 -0.31 6.98e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg01943577 chr7:158741284 NA -0.4 -5.76 -0.3 1.9e-8 Height; LUSC cis rs2425143 1.000 rs11696369 chr20:34378629 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -5.72 -0.3 2.33e-8 Blood protein levels; LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.08 -0.32 3.35e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg12419862 chr22:24373484 LOC391322 0.8 10.21 0.49 1.78e-21 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg15744005 chr10:104629667 AS3MT -0.34 -6.92 -0.35 2.31e-11 Arsenic metabolism; LUSC cis rs12497850 1.000 rs4858831 chr3:48735558 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.44 0.42 1e-15 Parkinson's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21776568 chr13:95254007 GPR180 0.43 6.44 0.33 4.13e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5769707 0.732 rs135865 chr22:50004829 G/A cg07959070 chr22:50026188 C22orf34 -0.32 -5.95 -0.31 6.72e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.32 -0.37 1.89e-12 Neuroticism; LUSC cis rs713477 0.654 rs12886848 chr14:55911138 G/A cg13175173 chr14:55914753 NA -0.3 -6.12 -0.32 2.66e-9 Pediatric bone mineral content (femoral neck); LUSC trans rs561341 1.000 rs483301 chr17:30293398 G/T cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 11.45 0.53 8.02e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1728785 1.000 rs1645936 chr16:68563743 A/G cg02508848 chr16:68573721 ZFP90 -0.43 -6.02 -0.31 4.61e-9 Ulcerative colitis; LUSC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg02534363 chr3:47050950 NBEAL2 0.38 6.17 0.32 2e-9 Colorectal cancer; LUSC cis rs12973672 0.680 rs564117 chr19:35718938 C/T cg12095397 chr19:35769544 USF2 0.39 5.8 0.3 1.5e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12737363 chr1:183604674 ARPC5;RGL1 0.45 6.51 0.34 2.81e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7075426 0.524 rs12779025 chr10:88188716 T/A cg07322936 chr10:88137208 NA 0.42 5.73 0.3 2.23e-8 Migraine without aura; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22929219 chr22:35796023 MCM5 -0.46 -6.01 -0.31 4.75e-9 Hepatitis; LUSC cis rs6582630 0.539 rs8189604 chr12:38308546 G/T cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.75e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs1348850 0.567 rs880898 chr2:178532470 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.91 0.31 8.37e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2544523 0.511 rs2544535 chr2:15906778 A/G cg26669897 chr2:15909070 NA 0.33 7.09 0.36 7.88e-12 Asthma or chronic obstructive pulmonary disease; LUSC cis rs4280164 0.551 rs1109152 chr14:24799024 G/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.61 -7.58 -0.38 3.51e-13 Parent of origin effect on language impairment (paternal); LUSC trans rs7944735 0.832 rs7130876 chr11:48050995 A/G cg03929089 chr4:120376271 NA 0.66 6.57 0.34 1.91e-10 Intraocular pressure; LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg09877947 chr5:131593287 PDLIM4 -0.53 -8.44 -0.42 9.5e-16 Acylcarnitine levels; LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg05025164 chr4:1340916 KIAA1530 0.53 8.21 0.41 4.9e-15 Longevity; LUSC cis rs6964587 1.000 rs10236397 chr7:91691601 C/T cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC trans rs61931739 0.892 rs73309466 chr12:34093146 A/G cg13010199 chr12:38710504 ALG10B -0.4 -6.06 -0.31 3.66e-9 Morning vs. evening chronotype; LUSC cis rs11608355 0.545 rs7139106 chr12:109908640 G/A cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs1957429 0.520 rs7144515 chr14:65333725 G/A cg23373153 chr14:65346875 NA -0.88 -8.1 -0.41 1.06e-14 Pediatric areal bone mineral density (radius); LUSC cis rs9309473 0.519 rs1881246 chr2:73650122 T/A cg20560298 chr2:73613845 ALMS1 0.48 7.41 0.38 1.02e-12 Metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02715291 chr4:54243685 FIP1L1 -0.45 -6.69 -0.34 9.65e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs61931739 0.517 rs34760282 chr12:34153711 G/T cg06521331 chr12:34319734 NA -0.45 -7.4 -0.38 1.13e-12 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23543263 chr13:22245177 FGF9 0.45 6.18 0.32 1.83e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs61931739 0.513 rs10743833 chr12:33897481 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.28 0.32 1.04e-9 Morning vs. evening chronotype; LUSC cis rs7828089 0.935 rs896378 chr8:22262321 T/C cg12081754 chr8:22256438 SLC39A14 0.53 8.28 0.41 2.96e-15 Verbal declarative memory; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg07677032 chr17:61819896 STRADA 0.54 9.05 0.44 1.17e-17 Prudent dietary pattern; LUSC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg11764359 chr7:65958608 NA 0.81 13.52 0.59 1.62e-33 Aortic root size; LUSC cis rs1499972 0.941 rs6794831 chr3:117642484 C/A cg07612923 chr3:117604196 NA 0.65 5.87 0.31 1.03e-8 Schizophrenia; LUSC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg22903471 chr2:27725779 GCKR -0.41 -7.14 -0.36 5.79e-12 Total body bone mineral density; LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg00684032 chr4:1343700 KIAA1530 0.38 6.6 0.34 1.62e-10 Obesity-related traits; LUSC cis rs6500395 1.000 rs7185899 chr16:48714101 A/G cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg00750074 chr16:89608354 SPG7 -0.53 -9.62 -0.47 1.64e-19 Multiple myeloma (IgH translocation); LUSC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg09034736 chr1:150693464 HORMAD1 0.44 5.98 0.31 5.83e-9 Melanoma; LUSC cis rs500891 0.525 rs6900022 chr6:84109944 T/A cg08257003 chr6:84140564 ME1 0.33 7.27 0.37 2.52e-12 Platelet-derived growth factor BB levels; LUSC cis rs6696846 0.749 rs7553876 chr1:205079915 A/G cg21545522 chr1:205238299 TMCC2 0.43 8.15 0.41 7.46e-15 Red blood cell count; LUSC cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg03146154 chr1:46216737 IPP 0.55 8.19 0.41 5.7e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg10556349 chr10:835070 NA 0.59 6.48 0.33 3.31e-10 Eosinophil percentage of granulocytes; LUSC cis rs10752881 0.967 rs6695746 chr1:182991355 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.94e-22 Colorectal cancer; LUSC cis rs977987 0.806 rs12930768 chr16:75464500 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.42e-11 Dupuytren's disease; LUSC cis rs6845621 0.700 rs10008431 chr4:18934125 T/C cg12196642 chr4:18937545 NA -0.36 -6.57 -0.34 1.91e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg12751644 chr20:60527061 NA -0.33 -5.91 -0.31 8.33e-9 Body mass index; LUSC trans rs9987353 0.784 rs4841116 chr8:9130116 G/C cg15556689 chr8:8085844 FLJ10661 -0.48 -6.19 -0.32 1.72e-9 Recombination measurement; LUSC cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg26314531 chr2:26401878 FAM59B -0.66 -8.86 -0.44 4.92e-17 Gut microbiome composition (summer); LUSC cis rs2425143 1.000 rs6060642 chr20:34449840 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.9 -0.31 9.06e-9 Blood protein levels; LUSC trans rs2789047 0.920 rs2817952 chr6:121187100 C/G cg27453922 chr7:148922355 ZNF282 0.39 6.16 0.32 2.08e-9 Peak creatinine levels in vancomycin therapy; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 2.92e-13 Prudent dietary pattern; LUSC cis rs7712401 0.601 rs187405 chr5:122294995 G/A cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11777782 chr19:18284937 IFI30 -0.45 -6.41 -0.33 4.83e-10 Hepatitis; LUSC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs433852 0.898 rs376524 chr19:49116438 A/G cg06677660 chr19:49140777 SEC1;DBP -0.58 -6.96 -0.36 1.85e-11 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg05552183 chr6:42928497 GNMT 0.46 7.62 0.38 2.61e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.41 -0.46 8.5e-19 Chronic sinus infection; LUSC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg14019146 chr3:50243930 SLC38A3 -0.33 -7.33 -0.37 1.73e-12 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.875 rs1660311 chr8:101330579 C/T cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg05623727 chr3:50126028 RBM5 0.32 5.97 0.31 6.05e-9 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg22903657 chr4:1355424 KIAA1530 -0.36 -5.89 -0.31 9.19e-9 Longevity; LUSC cis rs7103648 0.695 rs12577643 chr11:47467172 A/T cg20307385 chr11:47447363 PSMC3 0.89 14.54 0.62 1.84e-37 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg22963979 chr7:1858916 MAD1L1 -0.56 -8.54 -0.42 4.69e-16 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg00684032 chr4:1343700 KIAA1530 -0.34 -6.2 -0.32 1.64e-9 Obesity-related traits; LUSC cis rs3820928 0.874 rs2229813 chr2:227892720 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.55 -0.38 4.32e-13 Pulmonary function; LUSC cis rs597539 0.521 rs2060982 chr11:68612927 A/G cg21862992 chr11:68658383 NA 0.33 5.71 0.3 2.53e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg09085632 chr11:111637200 PPP2R1B 1.03 16.72 0.67 5.21e-46 Primary sclerosing cholangitis; LUSC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg00933542 chr6:150070202 PCMT1 0.31 6.48 0.33 3.2e-10 Lung cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13735691 chr19:36103707 HAUS5 -0.41 -5.97 -0.31 6.07e-9 Electrocardiographic conduction measures; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11503359 chr11:73882148 C2CD3;PPME1 -0.43 -6.44 -0.33 4.16e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs734999 0.588 rs2843404 chr1:2530558 T/C cg18932078 chr1:2524107 MMEL1 -0.32 -7.13 -0.36 6.33e-12 Ulcerative colitis; LUSC cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg03146154 chr1:46216737 IPP -0.5 -7.24 -0.37 3.08e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg22920501 chr2:26401640 FAM59B -0.75 -10.7 -0.51 3.66e-23 Gut microbiome composition (summer); LUSC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.69 11.42 0.53 9.91e-26 Systemic lupus erythematosus; LUSC cis rs34779708 0.897 rs9787566 chr10:35279455 T/A cg04310649 chr10:35416472 CREM -0.44 -6.58 -0.34 1.85e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7560272 0.538 rs13014700 chr2:73920121 C/G cg20560298 chr2:73613845 ALMS1 0.38 5.81 0.3 1.5e-8 Schizophrenia; LUSC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.62 -0.34 1.41e-10 Total body bone mineral density; LUSC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg17971929 chr21:40555470 PSMG1 0.67 11.22 0.52 5.16e-25 Cognitive function; LUSC cis rs3770081 1.000 rs60479377 chr2:86283948 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.93 -7.0 -0.36 1.39e-11 Facial emotion recognition (sad faces); LUSC cis rs7091068 0.671 rs1223296 chr10:95404621 T/C cg20715218 chr10:95462985 C10orf4 -0.56 -6.18 -0.32 1.84e-9 Urinary tract infection frequency; LUSC cis rs1595825 0.891 rs1968488 chr2:198721827 C/A cg00982548 chr2:198649783 BOLL -0.58 -7.27 -0.37 2.59e-12 Ulcerative colitis; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23661578 chr6:42981936 MEA1;KLHDC3 -0.43 -6.81 -0.35 4.5e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg05025164 chr4:1340916 KIAA1530 0.66 10.35 0.49 5.84e-22 Longevity; LUSC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.97 0.55 1.04e-27 Personality dimensions; LUSC cis rs1348850 0.651 rs4893821 chr2:178229352 A/G cg22681709 chr2:178499509 PDE11A 0.35 6.6 0.34 1.61e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.22 0.56 1.18e-28 Colorectal cancer; LUSC cis rs752010 0.841 rs7519983 chr1:42083369 C/T cg06885757 chr1:42089581 HIVEP3 0.44 9.0 0.44 1.74e-17 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs4988958 0.565 rs6760621 chr2:102999952 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.27e-12 Asthma (childhood onset); LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 6.81 0.35 4.56e-11 Platelet count; LUSC trans rs2832077 1.000 rs2832077 chr21:30141021 G/A cg14791747 chr16:20752902 THUMPD1 0.75 9.91 0.48 1.8e-20 Cognitive test performance; LUSC cis rs977987 0.835 rs4888380 chr16:75347690 T/C cg03315344 chr16:75512273 CHST6 0.53 10.12 0.48 3.61e-21 Dupuytren's disease; LUSC cis rs11190604 0.945 rs7091356 chr10:102292268 G/C cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.37 -0.33 6.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.8 -0.43 7.59e-17 Personality dimensions; LUSC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 5.95 0.31 6.85e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs3755132 0.929 rs2302930 chr2:15737343 A/G cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.68e-12 Wilms tumor; LUSC cis rs12464483 0.524 rs2593470 chr2:30887402 G/T cg07150166 chr2:30669952 LCLAT1 0.54 6.25 0.32 1.29e-9 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg06219351 chr7:158114137 PTPRN2 0.49 8.84 0.44 5.59e-17 Calcium levels; LUSC trans rs11098499 0.954 rs71614438 chr4:120371252 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg05738196 chr6:26577821 NA -0.59 -6.85 -0.35 3.48e-11 Intelligence (multi-trait analysis); LUSC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg24531977 chr5:56204891 C5orf35 -0.55 -8.16 -0.41 6.74e-15 Breast cancer;Breast cancer (early onset); LUSC cis rs11971779 0.648 rs6974099 chr7:139098566 A/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs68092024 0.704 rs793487 chr3:99495422 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -7.2 -0.37 4.13e-12 Cleft lip with or without cleft palate; LUSC cis rs4595586 0.545 rs4254106 chr12:39389342 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs9469578 0.579 rs73743305 chr6:33667660 C/T cg18708504 chr6:33715942 IP6K3 0.63 6.13 0.32 2.48e-9 Phosphorus levels; LUSC cis rs539096 0.540 rs3011217 chr1:44303266 C/T cg12908607 chr1:44402522 ARTN 0.46 7.47 0.38 7.06e-13 Intelligence (multi-trait analysis); LUSC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg17252645 chr8:143867129 LY6D -0.37 -6.57 -0.34 1.88e-10 Urinary tract infection frequency; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.76 0.39 1.02e-13 Prudent dietary pattern; LUSC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.66e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11190604 1.000 rs12355721 chr10:102244911 C/T cg16342193 chr10:102329863 NA -0.34 -6.14 -0.32 2.35e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7605827 0.897 rs10202600 chr2:15514461 T/C cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.71e-17 Educational attainment (years of education); LUSC cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.27 0.45 2.43e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg22117172 chr7:91764530 CYP51A1 -0.33 -5.88 -0.31 1e-8 Breast cancer; LUSC cis rs9392556 0.829 rs676683 chr6:4127253 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -6.43 -0.33 4.52e-10 Blood metabolite levels; LUSC cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg23583168 chr7:148888333 NA -0.92 -17.42 -0.69 8.41e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs800082 0.507 rs1121562 chr3:144259665 A/G cg24215973 chr2:240111563 HDAC4 0.48 7.52 0.38 5.07e-13 Smoking behavior; LUSC cis rs7267979 0.527 rs6083891 chr20:25574272 C/G cg03522245 chr20:25566470 NINL -0.39 -6.07 -0.32 3.38e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6456156 0.565 rs7750209 chr6:167482895 T/G cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC trans rs12310956 0.532 rs11052952 chr12:33988048 G/A cg26384229 chr12:38710491 ALG10B 0.75 11.76 0.54 5.82e-27 Morning vs. evening chronotype; LUSC cis rs4891159 0.790 rs7241485 chr18:74122325 C/T cg24786174 chr18:74118243 ZNF516 -0.83 -15.24 -0.64 3.51e-40 Longevity; LUSC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.06e-34 Prostate cancer; LUSC cis rs9462027 0.651 rs7769820 chr6:34760228 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC trans rs7726839 0.540 rs4957083 chr5:659343 T/C cg11887960 chr12:57824829 NA 0.52 6.49 0.33 3.12e-10 Obesity-related traits; LUSC cis rs7804356 1.000 rs10272457 chr7:26888155 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs11122272 0.735 rs2572248 chr1:231514942 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs9318086 0.648 rs7331047 chr13:24467342 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.44 6.61 0.34 1.48e-10 Myopia (pathological); LUSC trans rs61931739 0.500 rs10772154 chr12:34373271 A/C cg13010199 chr12:38710504 ALG10B 0.56 8.83 0.44 6.09e-17 Morning vs. evening chronotype; LUSC cis rs7577851 0.716 rs72833923 chr2:69666626 C/G cg10773587 chr2:69614142 GFPT1 0.57 6.23 0.32 1.38e-9 Parkinson's disease (age of onset); LUSC cis rs240764 0.817 rs240147 chr6:101078300 G/A cg09795085 chr6:101329169 ASCC3 0.42 6.04 0.31 4.03e-9 Neuroticism; LUSC cis rs751728 0.664 rs943474 chr6:33749834 G/C cg25922239 chr6:33757077 LEMD2 0.42 6.28 0.33 1.05e-9 Crohn's disease; LUSC cis rs4237845 0.837 rs7971877 chr12:58287630 T/G cg02175503 chr12:58329896 NA 0.6 9.69 0.47 1.01e-19 Intelligence (multi-trait analysis); LUSC cis rs6752107 0.503 rs13002340 chr2:234234959 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.47 6.91 0.35 2.49e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7954584 0.626 rs10840637 chr12:122427310 A/G cg13699009 chr12:122356056 WDR66 0.46 7.11 0.36 7.23e-12 Mean corpuscular volume; LUSC cis rs10484885 0.878 rs1328018 chr6:90297847 A/G cg13799429 chr6:90582589 CASP8AP2 0.77 7.43 0.38 9.35e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg02423579 chr7:2872169 GNA12 0.47 6.49 0.33 3.02e-10 Height; LUSC cis rs7575873 1 rs7575873 chr2:23962647 A/G cg20701182 chr2:24300061 SF3B14 0.75 7.46 0.38 7.57e-13 Birth weight; LUSC cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg06484146 chr7:12443880 VWDE -0.62 -6.24 -0.32 1.36e-9 Coronary artery disease; LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs796364 0.806 rs56216998 chr2:200944333 G/T cg23649088 chr2:200775458 C2orf69 -0.57 -7.0 -0.36 1.41e-11 Schizophrenia; LUSC trans rs2204008 0.660 rs2874343 chr12:38239096 C/T cg06521331 chr12:34319734 NA -0.39 -5.95 -0.31 6.67e-9 Bladder cancer; LUSC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.25 0.32 1.23e-9 Schizophrenia; LUSC cis rs6500602 0.727 rs2160567 chr16:4535557 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.5 6.71 0.34 8.58e-11 Schizophrenia; LUSC cis rs34779708 0.897 rs35784065 chr10:35353574 C/T cg04310649 chr10:35416472 CREM -0.4 -6.13 -0.32 2.5e-9 Inflammatory bowel disease;Crohn's disease; LUSC trans rs62103177 0.568 rs2365388 chr18:77973702 G/T cg05926928 chr17:57297772 GDPD1 0.7 6.89 0.35 2.81e-11 Opioid sensitivity; LUSC cis rs6681460 0.966 rs7519747 chr1:67140723 T/C cg02459107 chr1:67143332 SGIP1 0.49 9.18 0.45 4.59e-18 Presence of antiphospholipid antibodies; LUSC cis rs6582630 0.638 rs1829584 chr12:38526299 G/T cg26384229 chr12:38710491 ALG10B -0.57 -8.62 -0.43 2.75e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg14343924 chr8:8086146 FLJ10661 0.4 5.71 0.3 2.5e-8 Mood instability; LUSC cis rs7264396 0.563 rs2425137 chr20:34345396 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -6.88 -0.35 3.01e-11 Total cholesterol levels; LUSC cis rs7296418 0.699 rs1109559 chr12:123757861 C/T cg05973401 chr12:123451056 ABCB9 0.53 7.88 0.4 4.69e-14 Platelet count; LUSC cis rs714027 0.545 rs41161 chr22:30407652 T/C cg11564601 chr22:30592435 NA -0.35 -6.06 -0.31 3.76e-9 Lymphocyte counts; LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg09877947 chr5:131593287 PDLIM4 -0.46 -6.88 -0.35 3.01e-11 Breast cancer; LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.41 0.64 7.23e-41 Platelet count; LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.29 0.45 2.01e-18 Prudent dietary pattern; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14031059 chr19:19626956 NDUFA13;TSSK6 0.43 5.99 0.31 5.56e-9 Mosquito bite size; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.7 11.15 0.52 9.49e-25 Prudent dietary pattern; LUSC cis rs1559088 0.895 rs13345542 chr19:33586739 G/C cg03563238 chr19:33554763 RHPN2 -0.41 -6.56 -0.34 2.09e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg04586622 chr2:25135609 ADCY3 0.42 9.0 0.44 1.8e-17 Body mass index; LUSC cis rs7524258 0.868 rs1304712 chr1:7270538 C/T cg07173049 chr1:7289937 CAMTA1 0.33 6.74 0.35 6.81e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg06544989 chr22:39130855 UNC84B 0.33 5.67 0.3 3.02e-8 Menopause (age at onset); LUSC cis rs983392 0.805 rs7926729 chr11:59961786 C/T cg02771260 chr11:59836817 MS4A3 -0.36 -5.82 -0.3 1.4e-8 Alzheimer's disease (late onset); LUSC cis rs17685 0.725 rs2302436 chr7:75676988 A/T cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.73 0.39 1.27e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9640161 0.789 rs10248490 chr7:150051418 C/G cg21361702 chr7:150065534 REPIN1 0.56 7.98 0.4 2.39e-14 Blood protein levels;Circulating chemerin levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg21687924 chr11:3400496 ZNF195 0.45 6.57 0.34 1.92e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs870825 0.616 rs67641203 chr4:185623845 A/C cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg08392591 chr16:89556376 ANKRD11 0.5 7.66 0.39 2.02e-13 Multiple myeloma (IgH translocation); LUSC cis rs4077515 0.874 rs4498662 chr9:139290251 C/G cg14019695 chr9:139328340 INPP5E 0.42 8.06 0.4 1.41e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6940638 0.688 rs6456766 chr6:27019575 G/A cg05738196 chr6:26577821 NA -0.48 -6.89 -0.35 2.82e-11 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.95 19.54 0.73 3.02e-57 Prudent dietary pattern; LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg08888203 chr3:10149979 C3orf24 0.59 8.25 0.41 3.58e-15 Alzheimer's disease; LUSC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg11764359 chr7:65958608 NA -0.7 -10.81 -0.51 1.53e-23 Aortic root size; LUSC cis rs4478858 0.746 rs7520439 chr1:31688721 G/C cg00250761 chr1:31883323 NA 0.36 9.37 0.46 1.1e-18 Alcohol dependence; LUSC cis rs9649213 0.614 rs10953254 chr7:97914305 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.71 -9.96 -0.48 1.29e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.77e-16 Aortic root size; LUSC cis rs3008870 0.727 rs2755270 chr1:67474503 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.26 0.56 8.64e-29 Lymphocyte percentage of white cells; LUSC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg12379764 chr21:47803548 PCNT -0.44 -5.87 -0.31 1.06e-8 Testicular germ cell tumor; LUSC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg07636037 chr3:49044803 WDR6 0.43 6.26 0.32 1.21e-9 Resting heart rate; LUSC cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg06671706 chr8:8559999 CLDN23 0.49 6.61 0.34 1.48e-10 Obesity-related traits; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23924007 chr4:140099401 NA 0.41 6.73 0.35 7.3e-11 Triglycerides; LUSC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg20891558 chr2:74357851 NA 0.62 9.07 0.44 1.05e-17 Gestational age at birth (maternal effect); LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.68 0.6 4.04e-34 Platelet count; LUSC cis rs11098499 0.954 rs35063680 chr4:120387102 T/C cg24375607 chr4:120327624 NA 0.78 11.55 0.53 3.41e-26 Corneal astigmatism; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg01577475 chr2:114033581 PAX8;LOC440839 -0.29 -7.52 -0.38 4.94e-13 Lymphocyte counts; LUSC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg21963583 chr11:68658836 MRPL21 0.56 8.34 0.42 1.93e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs926938 0.563 rs360661 chr1:115455280 G/A cg12756093 chr1:115239321 AMPD1 0.41 6.16 0.32 2.04e-9 Autism; LUSC trans rs10802346 0.524 rs10802356 chr1:246385857 T/C cg13514129 chr1:39547527 MACF1 0.71 11.83 0.54 3.24e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC trans rs7829975 0.509 rs2945269 chr8:8115578 G/C cg21775007 chr8:11205619 TDH 0.5 7.25 0.37 2.93e-12 Mood instability; LUSC cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg08999081 chr20:33150536 PIGU 0.51 10.24 0.49 1.4e-21 Glomerular filtration rate (creatinine); LUSC cis rs4853525 0.923 rs13397788 chr2:191731503 G/A cg11845111 chr2:191398756 TMEM194B -0.39 -5.7 -0.3 2.64e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC trans rs35110281 0.782 rs4818856 chr21:45043495 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.54 0.53 3.8e-26 Mean corpuscular volume; LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs7814319 0.870 rs2292836 chr8:97239613 A/C cg20787634 chr8:97240163 UQCRB -0.34 -5.92 -0.31 7.9e-9 Lung function (FVC); LUSC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg02569458 chr12:86230093 RASSF9 0.52 8.64 0.43 2.3e-16 Major depressive disorder; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg02353165 chr6:42928485 GNMT 0.66 11.41 0.53 1.06e-25 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2835872 0.828 rs111576572 chr21:38989564 A/G cg20424643 chr21:39039972 KCNJ6 0.36 5.68 0.3 2.95e-8 Electroencephalographic traits in alcoholism; LUSC cis rs2273669 0.504 rs78662936 chr6:109449690 G/T cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg10295955 chr4:187884368 NA 1.05 24.35 0.8 5.28e-76 Lobe attachment (rater-scored or self-reported); LUSC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg19418458 chr7:158789849 NA -0.62 -10.26 -0.49 1.15e-21 Facial morphology (factor 20); LUSC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg15445000 chr17:37608096 MED1 -0.4 -6.79 -0.35 5.16e-11 Glomerular filtration rate (creatinine); LUSC cis rs2760061 0.846 rs3094912 chr1:228209815 T/A cg18477163 chr1:228402036 OBSCN 0.63 12.25 0.56 9.77e-29 Diastolic blood pressure; LUSC cis rs2288073 1.000 rs6708328 chr2:24412413 A/G cg06627628 chr2:24431161 ITSN2 -0.75 -10.62 -0.5 6.77e-23 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg26314531 chr2:26401878 FAM59B 0.73 10.06 0.48 5.58e-21 Gut microbiome composition (summer); LUSC cis rs6901250 0.851 rs339313 chr6:117179501 C/T cg12892004 chr6:117198278 RFX6 -0.45 -8.59 -0.43 3.3e-16 C-reactive protein levels; LUSC cis rs1403694 0.695 rs5029969 chr3:186434405 G/T cg12454167 chr3:186435060 KNG1 0.34 8.42 0.42 1.11e-15 Blood protein levels; LUSC cis rs1559088 0.847 rs10423531 chr19:33600140 T/C cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.03e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs10802346 0.545 rs1770003 chr1:246408356 A/G cg22732515 chr19:44031385 ETHE1 0.63 10.37 0.49 4.93e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.48 6.37 0.33 6.15e-10 Renal function-related traits (BUN); LUSC cis rs1152591 0.669 rs2978381 chr14:64766652 T/C cg21174375 chr14:64681225 SYNE2 0.32 5.83 0.3 1.29e-8 Atrial fibrillation; LUSC cis rs7590368 1.000 rs7576898 chr2:10958956 A/G cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs11785400 1.000 rs13266249 chr8:143732433 A/C cg24634471 chr8:143751801 JRK 0.6 8.88 0.44 4.24e-17 Schizophrenia; LUSC cis rs9646954 0.542 rs3828193 chr2:101031561 A/C cg12002119 chr2:101014098 CHST10 -0.36 -5.93 -0.31 7.48e-9 Intelligence (multi-trait analysis); LUSC cis rs926938 0.563 rs360645 chr1:115427218 A/G cg01522456 chr1:115632236 TSPAN2 -0.38 -5.92 -0.31 7.79e-9 Autism; LUSC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg14456004 chr13:21872349 NA 0.42 6.09 0.32 3.09e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs11756438 0.546 rs9489497 chr6:118999636 T/C cg21191810 chr6:118973309 C6orf204 0.35 5.91 0.31 8.34e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs7944735 0.575 rs34972471 chr11:48050391 G/A cg15704280 chr7:45808275 SEPT13 0.55 6.57 0.34 1.89e-10 Intraocular pressure; LUSC cis rs4964805 1.000 rs34307072 chr12:104196304 G/A cg02344784 chr12:104178138 NT5DC3 0.45 7.23 0.37 3.32e-12 Attention deficit hyperactivity disorder; LUSC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg14403583 chr14:105418241 AHNAK2 -0.55 -9.33 -0.45 1.54e-18 Rheumatoid arthritis; LUSC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.47 0.42 8.11e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs12594515 1.000 rs11855562 chr15:45995659 C/T cg19682013 chr15:45996608 NA 0.39 5.8 0.3 1.51e-8 Waist circumference;Weight; LUSC trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg15704280 chr7:45808275 SEPT13 0.73 8.36 0.42 1.72e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs2439831 0.850 rs2277531 chr15:44069069 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs10949662 1.000 rs28716556 chr7:157535368 T/C cg05731713 chr7:157510257 PTPRN2 0.41 7.32 0.37 1.9e-12 Intelligence (multi-trait analysis); LUSC cis rs7592578 0.603 rs12476782 chr2:191472880 G/A cg27211696 chr2:191398769 TMEM194B -0.43 -5.67 -0.3 3.06e-8 Diastolic blood pressure; LUSC cis rs7582720 1.000 rs72936873 chr2:203791333 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs478304 0.934 rs474483 chr11:65520060 T/G cg27068330 chr11:65405492 SIPA1 0.63 9.52 0.46 3.74e-19 Acne (severe); LUSC cis rs861020 0.604 rs3766612 chr1:210020013 G/T cg05527609 chr1:210001259 C1orf107 -0.9 -12.56 -0.57 6.66e-30 Orofacial clefts; LUSC cis rs28647808 0.748 rs28721280 chr9:136267318 C/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs3806843 0.547 rs246033 chr5:140332115 A/C cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs6601327 0.585 rs1394 chr8:9511654 G/A cg06636001 chr8:8085503 FLJ10661 -0.45 -6.33 -0.33 8.06e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg24675056 chr1:15929824 NA 0.49 8.51 0.42 6.14e-16 Systolic blood pressure; LUSC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg19077165 chr18:44547161 KATNAL2 0.42 6.39 0.33 5.53e-10 Personality dimensions; LUSC cis rs72781680 0.664 rs2712076 chr2:23993366 T/C cg08917208 chr2:24149416 ATAD2B 0.62 7.05 0.36 1.06e-11 Lymphocyte counts; LUSC cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.39 0.46 9.31e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs4820539 1.000 rs2157710 chr22:23457486 C/T cg21100191 chr22:23484243 RTDR1 0.91 15.24 0.64 3.65e-40 Bone mineral density; LUSC cis rs7824557 0.628 rs7841394 chr8:11185671 G/T cg21775007 chr8:11205619 TDH 0.76 12.8 0.57 8.31e-31 Retinal vascular caliber; LUSC cis rs1832871 0.672 rs56075516 chr6:158745752 G/A cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg26384229 chr12:38710491 ALG10B 0.89 15.27 0.64 2.63e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg08999081 chr20:33150536 PIGU 0.37 6.56 0.34 2.06e-10 Height; LUSC cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg24642439 chr20:33292090 TP53INP2 -0.49 -7.48 -0.38 6.8e-13 Height; LUSC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.71 0.47 8.71e-20 Personality dimensions; LUSC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg03709012 chr19:19516395 GATAD2A -0.77 -11.95 -0.55 1.19e-27 Tonsillectomy; LUSC cis rs79349575 0.749 rs519537 chr17:46971140 G/A cg22482690 chr17:47019901 SNF8 0.4 7.52 0.38 5.04e-13 Type 2 diabetes; LUSC cis rs10028773 0.568 rs6838457 chr4:120267367 A/G cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.4e-19 Educational attainment; LUSC cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.29 0.69 2.78e-48 Chronic sinus infection; LUSC cis rs9399135 0.660 rs4267967 chr6:135272477 T/G cg24558204 chr6:135376177 HBS1L 0.57 8.46 0.42 8.44e-16 Red blood cell count; LUSC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg23711669 chr6:146136114 FBXO30 0.81 14.04 0.61 1.6e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs4721295 0.546 rs1637766 chr7:2204400 G/A cg08027265 chr7:2291960 NA 0.36 6.05 0.31 3.94e-9 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Bladder cancer; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg06145435 chr7:1022769 CYP2W1 0.3 6.18 0.32 1.89e-9 Longevity;Endometriosis; LUSC cis rs7580658 0.895 rs4662722 chr2:128102569 T/C cg09760422 chr2:128146352 NA -0.3 -6.36 -0.33 6.57e-10 Protein C levels; LUSC cis rs9929218 0.953 rs3114411 chr16:68734591 G/T cg02972257 chr16:68554789 NA -0.46 -6.09 -0.32 3.13e-9 Colorectal cancer; LUSC cis rs76935404 0.736 rs57274441 chr19:41431422 T/G cg04176888 chr19:41596066 CYP2A13 0.36 5.67 0.3 3.12e-8 nicotine metabolite ratio in current smokers; LUSC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg04369109 chr6:150039330 LATS1 -0.6 -8.83 -0.43 6.2e-17 Lung cancer; LUSC cis rs1801251 1.000 rs2592105 chr2:233645968 C/G cg25237894 chr2:233734115 C2orf82 0.36 6.65 0.34 1.23e-10 Coronary artery disease; LUSC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg17294928 chr15:75287854 SCAMP5 0.41 6.0 0.31 5.18e-9 Breast cancer; LUSC cis rs3733631 1.000 rs3733631 chr4:104641103 G/C cg24090629 chr4:104641072 TACR3 -0.5 -6.4 -0.33 5.32e-10 Menarche (age at onset); LUSC cis rs4889855 0.505 rs7501740 chr17:78610345 A/G cg16591659 chr17:78472290 NA -0.33 -5.82 -0.3 1.37e-8 Fractional excretion of uric acid; LUSC cis rs11168618 0.870 rs7302209 chr12:48895384 T/C cg24011408 chr12:48396354 COL2A1 0.4 6.38 0.33 5.93e-10 Adiponectin levels; LUSC cis rs1691799 0.899 rs1168308 chr12:66742183 A/G cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.33e-31 White blood cell count (basophil); LUSC cis rs617219 0.889 rs56064275 chr5:78436952 C/T cg24856658 chr5:78533917 JMY -0.31 -5.79 -0.3 1.62e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.54 6.96 0.36 1.77e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs7267979 1.000 rs2482940 chr20:25349830 C/T cg03522245 chr20:25566470 NINL -0.36 -5.8 -0.3 1.56e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9788682 0.747 rs2958719 chr15:78743029 G/A cg18825076 chr15:78729989 IREB2 -0.45 -6.24 -0.32 1.3e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg24675658 chr1:53192096 ZYG11B -0.56 -8.81 -0.43 6.98e-17 Monocyte count; LUSC cis rs2710642 0.849 rs4671450 chr2:62981869 C/A cg17519650 chr2:63277830 OTX1 -0.52 -7.22 -0.37 3.63e-12 LDL cholesterol levels;LDL cholesterol; LUSC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg04850211 chr1:228464232 OBSCN -0.33 -5.94 -0.31 7.25e-9 Diastolic blood pressure; LUSC cis rs6138458 0.816 rs2151463 chr20:24911819 A/C cg26195577 chr20:24973756 C20orf3 1.12 18.1 0.7 1.58e-51 Blood protein levels; LUSC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11890956 chr21:40555474 PSMG1 -0.91 -15.91 -0.66 8.13e-43 Cognitive function; LUSC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs9314323 0.767 rs1865305 chr8:26233325 G/A cg11498726 chr8:26250323 BNIP3L -0.46 -6.61 -0.34 1.5e-10 Red cell distribution width; LUSC cis rs10979 1.000 rs35354710 chr6:143886454 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -11.98 -0.55 9.52e-28 Hypospadias; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg25726756 chr21:47582351 C21orf56 -0.33 -5.73 -0.3 2.2e-8 Testicular germ cell tumor; LUSC cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.9 0.31 8.81e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs9329221 0.537 rs1351876 chr8:9984777 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.09 -0.36 8.16e-12 Neuroticism; LUSC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg17366294 chr4:99064904 C4orf37 0.56 9.81 0.47 3.98e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg05283184 chr6:79620031 NA -0.57 -12.14 -0.55 2.5e-28 Intelligence (multi-trait analysis); LUSC cis rs9902453 0.967 rs3813034 chr17:28524804 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.95 0.44 2.58e-17 Coffee consumption (cups per day); LUSC cis rs2147959 0.941 rs6426503 chr1:228651011 A/G cg18477163 chr1:228402036 OBSCN -0.43 -5.97 -0.31 6.22e-9 Adult asthma; LUSC cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg08508325 chr11:3079039 CARS -0.5 -12.22 -0.56 1.27e-28 Longevity; LUSC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg09021430 chr5:549028 NA -0.53 -7.49 -0.38 6.08e-13 Lung disease severity in cystic fibrosis; LUSC cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg11266682 chr4:10021025 SLC2A9 -0.53 -9.92 -0.48 1.72e-20 Bone mineral density; LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs9650315 0.810 rs36122101 chr8:57202560 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.31 0.37 1.93e-12 Height; LUSC cis rs1801251 1.000 rs283469 chr2:233656997 G/T cg25237894 chr2:233734115 C2orf82 0.35 6.42 0.33 4.6e-10 Coronary artery disease; LUSC cis rs9902453 0.845 rs12601963 chr17:28246358 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.74 0.47 6.81e-20 Coffee consumption (cups per day); LUSC cis rs1775715 0.707 rs2808079 chr10:32167385 C/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.64 0.34 1.28e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9814567 1.000 rs13090969 chr3:134307257 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs17102423 0.755 rs7154852 chr14:65553822 C/A cg11161011 chr14:65562177 MAX -0.81 -12.51 -0.56 1.01e-29 Obesity-related traits; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg24562927 chr17:4075322 ANKFY1 -0.4 -6.33 -0.33 7.92e-10 N-glycan levels; LUSC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg08392591 chr16:89556376 ANKRD11 0.46 7.04 0.36 1.1e-11 Multiple myeloma (IgH translocation); LUSC cis rs7202877 0.519 rs3743606 chr16:75335474 C/A cg04384234 chr16:75411784 CFDP1 -0.6 -7.67 -0.39 1.96e-13 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7808935 0.914 rs67746093 chr7:27985524 C/G cg22168087 chr7:27702803 HIBADH 0.57 6.77 0.35 5.87e-11 Prostate cancer; LUSC cis rs1775715 0.835 rs11008701 chr10:32241096 A/G cg26784012 chr10:32216390 ARHGAP12 0.36 5.76 0.3 1.91e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg07701084 chr6:150067640 NUP43 0.55 8.14 0.41 7.83e-15 Lung cancer; LUSC cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.77 -0.43 8.96e-17 Monocyte percentage of white cells; LUSC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg13206674 chr6:150067644 NUP43 0.6 9.5 0.46 4.09e-19 Lung cancer; LUSC trans rs17780086 0.529 rs7406406 chr17:30220153 T/G cg20587970 chr11:113659929 NA -0.63 -8.76 -0.43 1.01e-16 Height; LUSC cis rs7267979 1.000 rs2257432 chr20:25271086 T/C cg08601574 chr20:25228251 PYGB 0.43 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3740713 1.000 rs73440615 chr11:18467283 T/C cg15463284 chr11:18477534 LDHAL6A -0.5 -5.69 -0.3 2.72e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12893668 0.703 rs7140568 chr14:104041374 C/T cg08213375 chr14:104286397 PPP1R13B 0.38 6.24 0.32 1.29e-9 Reticulocyte count; LUSC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg11062466 chr8:58055876 NA 0.43 5.79 0.3 1.63e-8 Developmental language disorder (linguistic errors); LUSC cis rs1983891 1.000 rs4714486 chr6:41542417 C/T cg15051332 chr6:41514432 FOXP4 0.41 5.91 0.31 8.43e-9 Prostate cancer; LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg26335602 chr6:28129616 ZNF389 0.43 5.75 0.3 1.98e-8 Depression; LUSC cis rs8027181 0.839 rs2277598 chr15:73027478 T/C cg25632853 chr15:73088954 NA 0.31 6.18 0.32 1.87e-9 Triglyceride levels; LUSC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg12311346 chr5:56204834 C5orf35 -0.96 -13.89 -0.6 6.39e-35 Initial pursuit acceleration; LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.67 10.58 0.5 9.14e-23 Prudent dietary pattern; LUSC cis rs1008375 0.966 rs12503540 chr4:17698781 C/G cg18681998 chr4:17616180 MED28 -0.74 -12.38 -0.56 3.01e-29 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2953174 0.938 rs2975764 chr2:241534381 A/G cg07929629 chr2:241523174 NA 0.47 6.09 0.32 3.18e-9 Bipolar disorder; LUSC cis rs9549367 0.789 rs2287248 chr13:113889226 T/C cg00898013 chr13:113819073 PROZ -0.57 -8.12 -0.41 9.33e-15 Platelet distribution width; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg21782813 chr7:2030301 MAD1L1 0.42 7.26 0.37 2.74e-12 Bipolar disorder and schizophrenia; LUSC cis rs8044995 0.517 rs61593058 chr16:68384496 T/C cg09835421 chr16:68378352 PRMT7 -0.61 -7.59 -0.38 3.25e-13 Schizophrenia; LUSC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2985684 1.000 rs8014170 chr14:50071694 C/G cg04989706 chr14:50066350 PPIL5 -0.46 -5.96 -0.31 6.27e-9 Carotid intima media thickness; LUSC cis rs12295403 0.723 rs12787397 chr11:18687025 C/T cg09887367 chr11:18690185 NA -0.32 -5.73 -0.3 2.3e-8 Ovarian reserve; LUSC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs13126513 0.519 rs7659550 chr4:100554402 G/T cg05468953 chr4:100565104 NA 0.36 6.68 0.34 9.76e-11 Metabolite levels (MHPG); LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg02951883 chr7:2050386 MAD1L1 -0.37 -6.44 -0.33 4.28e-10 Bipolar disorder and schizophrenia; LUSC cis rs7172677 0.501 rs8041446 chr15:75394517 C/T cg14664628 chr15:75095509 CSK 0.43 6.07 0.32 3.43e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg03790207 chr6:42947109 PEX6 -0.45 -6.76 -0.35 6.08e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs8099014 1.000 rs7238719 chr18:56132195 T/C cg12907477 chr18:56117327 MIR122 0.41 6.38 0.33 6.02e-10 Platelet count; LUSC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg12365402 chr11:9010492 NRIP3 -0.49 -9.33 -0.45 1.5e-18 Hemoglobin concentration; LUSC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg07701084 chr6:150067640 NUP43 0.56 8.35 0.42 1.84e-15 Lung cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11554525 chr8:33342681 MAK16 0.77 5.96 0.31 6.24e-9 Cognitive performance; LUSC cis rs117352156 0.943 rs2368966 chr10:29214609 A/G cg06394621 chr10:29236369 NA 0.47 6.34 0.33 7.38e-10 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs4664308 0.967 rs17241792 chr2:160915205 C/T cg03641300 chr2:160917029 PLA2R1 -0.68 -11.52 -0.53 4.37e-26 Idiopathic membranous nephropathy; LUSC trans rs45509595 0.841 rs2747054 chr6:27783359 A/G cg01620082 chr3:125678407 NA -0.69 -7.05 -0.36 1.06e-11 Breast cancer; LUSC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg22823121 chr1:150693482 HORMAD1 0.46 6.58 0.34 1.82e-10 Melanoma; LUSC cis rs2625529 0.652 rs1481862 chr15:72245648 G/A cg16672083 chr15:72433130 SENP8 0.48 8.06 0.4 1.34e-14 Red blood cell count; LUSC cis rs67696533 0.711 rs1108445 chr20:31127647 A/G cg13636640 chr20:31349939 DNMT3B 0.46 6.4 0.33 5.17e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg22496339 chr2:162101262 NA 0.49 7.07 0.36 9.32e-12 Intelligence (multi-trait analysis); LUSC cis rs2795502 0.938 rs3121324 chr10:43379515 C/T cg20628663 chr10:43360327 NA 0.65 9.56 0.46 2.69e-19 Blood protein levels; LUSC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg05347473 chr6:146136440 FBXO30 0.54 9.03 0.44 1.44e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs3740540 0.507 rs942015 chr10:126289932 G/T cg04949429 chr10:126290192 LHPP 0.36 7.65 0.39 2.18e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.32 -0.33 8.19e-10 Lung cancer; LUSC trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg15704280 chr7:45808275 SEPT13 -0.63 -7.62 -0.38 2.63e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs8060686 0.623 rs6499163 chr16:68243486 G/T cg26727032 chr16:67993705 SLC12A4 -0.42 -6.42 -0.33 4.71e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6754311 0.597 rs2082729 chr2:136550109 C/T cg07169764 chr2:136633963 MCM6 -0.6 -7.81 -0.39 7.66e-14 Mosquito bite size; LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg21782813 chr7:2030301 MAD1L1 0.58 10.31 0.49 8.12e-22 Bipolar disorder and schizophrenia; LUSC cis rs9300255 0.568 rs1727300 chr12:123664205 C/T cg00376283 chr12:123451042 ABCB9 0.65 8.16 0.41 7.13e-15 Neutrophil percentage of white cells; LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg03351412 chr1:154909251 PMVK 0.51 7.9 0.4 4.21e-14 Prostate cancer; LUSC cis rs12681287 0.640 rs7830480 chr8:87403137 T/C cg27223183 chr8:87520930 FAM82B 0.55 7.45 0.38 8.05e-13 Caudate activity during reward; LUSC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg24562669 chr7:97807699 LMTK2 0.35 6.06 0.31 3.68e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs7312933 0.585 rs7969814 chr12:42669657 C/G cg01256987 chr12:42539512 GXYLT1 -0.42 -7.77 -0.39 1e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1712517 0.844 rs1163081 chr10:105029840 G/C cg05636881 chr10:105038444 INA 0.39 6.56 0.34 2.03e-10 Migraine; LUSC cis rs243505 1.000 rs243516 chr7:148426271 T/G cg09806900 chr7:148480153 CUL1 -0.48 -6.94 -0.35 2.08e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4132509 0.793 rs10927047 chr1:243803677 A/T cg21452805 chr1:244014465 NA 0.58 6.0 0.31 5.28e-9 RR interval (heart rate); LUSC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg04352962 chr1:209979756 IRF6 0.52 5.77 0.3 1.83e-8 Coronary artery disease; LUSC cis rs7824557 0.628 rs6988922 chr8:11194911 A/G cg21775007 chr8:11205619 TDH 0.8 13.74 0.6 2.36e-34 Retinal vascular caliber; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg22907277 chr7:1156413 C7orf50 0.48 7.2 0.37 4.14e-12 Longevity;Endometriosis; LUSC cis rs708547 0.874 rs7674167 chr4:57721477 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.59 -7.78 -0.39 9.08e-14 Response to bleomycin (chromatid breaks); LUSC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.65 0.57 3.13e-30 Cognitive test performance; LUSC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg00933542 chr6:150070202 PCMT1 0.3 5.82 0.3 1.41e-8 Lung cancer; LUSC cis rs6977940 0.730 rs11770451 chr7:2887990 G/T cg19731401 chr7:2775893 GNA12 0.72 8.0 0.4 2.03e-14 White matter integrity; LUSC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg26769984 chr7:1090371 C7orf50 0.55 8.79 0.43 7.97e-17 Bronchopulmonary dysplasia; LUSC cis rs148387471 1 rs148387471 chr3:127057551 ATAG/A cg25436886 chr3:127056972 NA -0.49 -6.7 -0.34 8.94e-11 Interleukin-10 levels;Interleukin-13 levels; LUSC cis rs9467711 0.606 rs34622023 chr6:26362119 A/T cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg13319975 chr6:146136371 FBXO30 -0.38 -5.7 -0.3 2.63e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs4808199 0.948 rs7250368 chr19:19452763 G/A cg03709012 chr19:19516395 GATAD2A 0.96 11.83 0.54 3.41e-27 Nonalcoholic fatty liver disease; LUSC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.13e-12 Mean platelet volume; LUSC cis rs1949733 0.628 rs2688231 chr4:8490981 G/A cg11789530 chr4:8429930 ACOX3 0.55 8.79 0.43 7.76e-17 Response to antineoplastic agents; LUSC cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.56 -0.57 6.61e-30 Chronic sinus infection; LUSC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs9612 1.000 rs12611034 chr19:44268678 C/T cg08581076 chr19:44259116 C19orf61 0.48 5.92 0.31 8.17e-9 Exhaled nitric oxide output; LUSC cis rs62400317 0.793 rs12210230 chr6:45344854 T/A cg18551225 chr6:44695536 NA -0.43 -7.18 -0.37 4.6e-12 Total body bone mineral density; LUSC cis rs10857712 0.754 rs2297033 chr10:135234848 C/T cg01444801 chr10:135216882 MTG1 -0.49 -6.43 -0.33 4.52e-10 Systemic lupus erythematosus; LUSC cis rs35146811 0.700 rs858513 chr7:99825558 G/A cg22906224 chr7:99728672 NA -0.5 -6.94 -0.35 2.09e-11 Coronary artery disease; LUSC cis rs13242816 1.000 rs34234085 chr7:116114066 G/A cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.55 0.53 3.44e-26 Hip circumference adjusted for BMI; LUSC cis rs10979 0.965 rs34373782 chr6:143888258 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg03146154 chr1:46216737 IPP 0.56 8.36 0.42 1.77e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1949733 0.701 rs2688222 chr4:8473735 C/A cg11789530 chr4:8429930 ACOX3 0.55 8.44 0.42 9.93e-16 Response to antineoplastic agents; LUSC cis rs6598163 0.520 rs12813376 chr12:132302324 C/T cg03570417 chr12:132312461 MMP17 0.37 6.76 0.35 6.28e-11 Migraine; LUSC cis rs12893668 0.703 rs34896432 chr14:104027995 C/T cg08213375 chr14:104286397 PPP1R13B 0.36 5.91 0.31 8.48e-9 Reticulocyte count; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03699307 chr16:75600014 GABARAPL2 0.35 6.0 0.31 5.21e-9 Triglycerides; LUSC cis rs2404602 0.692 rs35138393 chr15:76977617 G/A cg22467129 chr15:76604101 ETFA -0.45 -7.05 -0.36 1.02e-11 Blood metabolite levels; LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg08683831 chr4:1404607 NA -0.32 -5.66 -0.3 3.3e-8 Obesity-related traits; LUSC cis rs12367572 0.965 rs1506676 chr12:45237401 T/C cg04608330 chr12:45269318 NELL2 -0.54 -8.51 -0.42 5.97e-16 Gut microbiome composition (summer); LUSC trans rs3749237 0.964 rs13084243 chr3:49821878 G/C cg21659725 chr3:3221576 CRBN 0.61 8.48 0.42 7.14e-16 Resting heart rate; LUSC cis rs3857536 0.566 rs208463 chr6:66913962 T/A cg07460842 chr6:66804631 NA -0.77 -10.42 -0.5 3.33e-22 Blood trace element (Cu levels); LUSC cis rs7614311 0.731 rs3774727 chr3:63977875 A/G cg22134162 chr3:63841271 THOC7 -0.49 -5.98 -0.31 5.68e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg12927641 chr6:109611667 NA -0.41 -7.24 -0.37 3.02e-12 Reticulocyte fraction of red cells; LUSC cis rs796364 0.525 rs10931895 chr2:201143242 C/T cg23649088 chr2:200775458 C2orf69 0.54 7.33 0.37 1.71e-12 Schizophrenia; LUSC cis rs11756438 0.572 rs1771756 chr6:119018502 C/T cg21191810 chr6:118973309 C6orf204 0.34 5.74 0.3 2.09e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs72960926 0.744 rs11756265 chr6:74901250 T/C cg03266952 chr6:74778945 NA -0.76 -6.05 -0.31 3.85e-9 Metabolite levels (MHPG); LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg08219700 chr8:58056026 NA 0.63 8.08 0.4 1.19e-14 Developmental language disorder (linguistic errors); LUSC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg22508957 chr16:3507546 NAT15 0.45 6.41 0.33 4.94e-10 Body mass index (adult); LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg00024416 chr22:24240387 NA 0.31 5.67 0.3 3.02e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs8180040 0.726 rs6774733 chr3:46991241 G/A cg16586182 chr3:47516702 SCAP -0.51 -8.0 -0.4 2.09e-14 Colorectal cancer; LUSC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.67 -10.25 -0.49 1.33e-21 Menarche (age at onset); LUSC cis rs8017423 0.967 rs2282030 chr14:90730265 G/A cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs1448094 0.785 rs6539941 chr12:86452813 G/T cg00310523 chr12:86230176 RASSF9 -0.35 -6.35 -0.33 6.92e-10 Major depressive disorder; LUSC cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg23158103 chr7:148848205 ZNF398 -0.48 -8.0 -0.4 2.13e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11098499 0.909 rs7659501 chr4:120371552 G/T cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC trans rs7893279 0.822 rs6415973 chr10:18715168 C/T cg01840055 chr3:141338555 NA 0.5 5.99 0.31 5.41e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs55871839 0.708 rs13261666 chr8:59814666 G/T cg07426533 chr8:59803705 TOX -0.36 -5.8 -0.3 1.57e-8 Pneumonia; LUSC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.15 -0.49 2.8e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg20019365 chr2:219134978 PNKD;AAMP -0.53 -8.21 -0.41 4.96e-15 Colorectal cancer; LUSC cis rs7267979 1.000 rs2482931 chr20:25334445 G/A cg08601574 chr20:25228251 PYGB -0.43 -6.63 -0.34 1.32e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs56399783 0.803 rs17132665 chr7:2802173 T/C cg14895029 chr7:2775587 GNA12 0.51 6.1 0.32 2.96e-9 Childhood ear infection; LUSC cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg07148914 chr20:33460835 GGT7 0.53 8.17 0.41 6.38e-15 Height; LUSC cis rs870825 0.698 rs28412823 chr4:185638829 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.74 0.6 2.31e-34 Blood protein levels; LUSC cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.68 -0.43 1.82e-16 Schizophrenia; LUSC cis rs16854884 0.837 rs13083224 chr3:143801696 C/T cg06585982 chr3:143692056 C3orf58 0.44 6.54 0.34 2.26e-10 Economic and political preferences (feminism/equality); LUSC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg16743903 chr16:89593216 SPG7 -0.39 -6.06 -0.31 3.62e-9 Multiple myeloma (IgH translocation); LUSC trans rs12310956 0.532 rs7967627 chr12:33974669 G/T cg13010199 chr12:38710504 ALG10B 0.51 7.68 0.39 1.83e-13 Morning vs. evening chronotype; LUSC cis rs9649213 0.614 rs12539761 chr7:98013839 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.72 -10.12 -0.48 3.56e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.09 0.4 1.12e-14 Homoarginine levels; LUSC cis rs4409675 0.576 rs6565 chr1:28213157 T/C cg23691781 chr1:28212827 C1orf38 0.32 7.61 0.38 2.83e-13 Corneal astigmatism; LUSC cis rs9517313 0.554 rs3809366 chr13:99230266 C/T cg07423050 chr13:99094983 FARP1 -0.52 -9.41 -0.46 8.16e-19 Neuroticism; LUSC cis rs11608355 0.532 rs7968387 chr12:109788019 A/C cg19025524 chr12:109796872 NA -0.44 -8.14 -0.41 7.81e-15 Neuroticism; LUSC cis rs1949733 0.655 rs2631736 chr4:8478421 C/G cg13073564 chr4:8508604 NA 0.43 8.24 0.41 3.88e-15 Response to antineoplastic agents; LUSC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.69 0.47 9.74e-20 Personality dimensions; LUSC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg03060546 chr3:49711283 APEH 0.71 11.95 0.55 1.23e-27 Resting heart rate; LUSC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 8.53 0.42 5.32e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.32 0.56 5.42e-29 Motion sickness; LUSC cis rs12973672 1.000 rs10410675 chr19:35768828 T/C cg12095397 chr19:35769544 USF2 0.44 6.91 0.35 2.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2607426 1.000 rs2607426 chr19:41274713 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.6 5.76 0.3 1.9e-8 Blood protein levels; LUSC cis rs1419980 0.673 rs2377086 chr12:7753798 C/T cg25828445 chr12:7781288 NA 0.62 6.61 0.34 1.57e-10 HDL cholesterol levels; LUSC cis rs4144743 0.702 rs16941733 chr17:45318289 T/C cg18085866 chr17:45331354 ITGB3 -0.79 -7.64 -0.39 2.3e-13 Body mass index; LUSC cis rs2742234 0.656 rs1864400 chr10:43610366 G/A cg02780029 chr10:43622663 RET -0.35 -5.99 -0.31 5.42e-9 Hirschsprung disease; LUSC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.84 -13.67 -0.6 4.23e-34 Hip circumference adjusted for BMI; LUSC cis rs2854160 0.581 rs2727319 chr17:61960215 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.59 8.81 0.43 6.73e-17 Height; LUSC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg13206674 chr6:150067644 NUP43 0.59 9.47 0.46 5.18e-19 Lung cancer; LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg22920501 chr2:26401640 FAM59B 0.71 10.8 0.51 1.56e-23 Gut microbiome composition (summer); LUSC cis rs12618769 0.652 rs76525766 chr2:99221088 A/G cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs911119 0.657 rs2145231 chr20:23625547 A/G cg16589663 chr20:23618590 CST3 -0.52 -5.91 -0.31 8.55e-9 Chronic kidney disease; LUSC cis rs1728785 0.901 rs2862781 chr16:68639234 A/T cg02972257 chr16:68554789 NA -0.5 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC trans rs11098499 0.866 rs6857892 chr4:120282696 G/T cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg24739457 chr1:205821442 NA 0.35 5.99 0.31 5.49e-9 Menarche (age at onset); LUSC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Vitiligo; LUSC cis rs141518190 1 rs141518190 chr15:78900647 A/G cg18825076 chr15:78729989 IREB2 -0.51 -7.91 -0.4 3.77e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9303401 0.659 rs34468504 chr17:56648277 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC cis rs765787 0.530 rs28526629 chr15:45540462 C/T cg25801113 chr15:45476975 SHF 0.34 6.85 0.35 3.49e-11 Uric acid levels; LUSC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg06112835 chr11:68658793 MRPL21 0.51 7.94 0.4 3.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -6.98 -0.36 1.61e-11 Breast cancer; LUSC cis rs12900413 0.959 rs67279010 chr15:90318341 T/C cg24249390 chr15:90295951 MESP1 -0.44 -6.55 -0.34 2.2e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg05717871 chr11:638507 DRD4 -0.33 -5.84 -0.3 1.26e-8 Systemic lupus erythematosus; LUSC cis rs7582180 0.629 rs4851298 chr2:100949827 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg15839431 chr19:19639596 YJEFN3 -0.59 -6.51 -0.34 2.79e-10 Bipolar disorder; LUSC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs4252134 0.959 rs4252093 chr6:161133685 A/G cg00639886 chr12:54943102 PDE1B -0.44 -6.3 -0.33 9.18e-10 Giant cell arteritis; LUSC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.95 -0.31 6.78e-9 Intelligence (multi-trait analysis); LUSC cis rs7953249 0.807 rs7310409 chr12:121424861 A/G cg02403541 chr12:121454288 C12orf43 -0.61 -9.05 -0.44 1.17e-17 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs11971779 0.590 rs59602547 chr7:139117023 G/A cg07862535 chr7:139043722 LUC7L2 0.6 7.62 0.39 2.56e-13 Diisocyanate-induced asthma; LUSC cis rs7605378 1.000 rs2346662 chr2:200679158 C/T cg23649088 chr2:200775458 C2orf69 0.51 7.72 0.39 1.32e-13 Osteoporosis; LUSC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg23985595 chr17:80112537 CCDC57 -0.3 -5.7 -0.3 2.64e-8 Life satisfaction; LUSC cis rs432925 0.600 rs385862 chr16:344659 A/G cg06233593 chr16:337645 AXIN1 0.44 8.18 0.41 6.13e-15 Morning vs. evening chronotype; LUSC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg24531977 chr5:56204891 C5orf35 -1.03 -15.7 -0.65 5.56e-42 Initial pursuit acceleration; LUSC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg22029157 chr1:209979665 IRF6 0.71 8.39 0.42 1.37e-15 Coronary artery disease; LUSC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg05785598 chr3:49045655 WDR6 0.34 5.97 0.31 5.99e-9 Parkinson's disease; LUSC cis rs3862435 0.764 rs9672149 chr15:91059224 T/A cg22089800 chr15:90895588 ZNF774 -0.57 -5.74 -0.3 2.14e-8 Response to exercise (triglyceride level interaction); LUSC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.08 0.32 3.21e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4718428 1.000 rs4718428 chr7:66421446 T/G cg11764359 chr7:65958608 NA 0.44 6.4 0.33 5.4e-10 Corneal structure; LUSC cis rs17621444 0.505 rs11199145 chr10:121775105 C/T cg02041677 chr10:121771263 NA -0.34 -6.47 -0.33 3.53e-10 IgG glycosylation; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13566851 chr6:143857813 NA 0.45 6.84 0.35 3.7e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg06494592 chr3:125709126 NA -0.53 -6.03 -0.31 4.35e-9 Blood pressure (smoking interaction); LUSC cis rs7615952 0.736 rs9862893 chr3:125686974 A/G cg05084668 chr3:125655381 ALG1L -0.82 -11.52 -0.53 4.58e-26 Blood pressure (smoking interaction); LUSC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg09359103 chr1:154839909 KCNN3 -0.72 -16.45 -0.67 5.91e-45 Prostate cancer; LUSC cis rs4243830 0.522 rs10864614 chr1:6596008 G/A cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.05 -0.31 3.99e-9 Body mass index; LUSC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg18357526 chr6:26021779 HIST1H4A -0.37 -5.74 -0.3 2.09e-8 Intelligence (multi-trait analysis); LUSC cis rs6714710 0.603 rs116309486 chr2:98493359 A/G cg26665480 chr2:98280029 ACTR1B 0.61 8.9 0.44 3.72e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03001875 chr1:234614834 TARBP1 0.45 6.11 0.32 2.82e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7572644 0.699 rs7426295 chr2:28078994 G/A cg27432699 chr2:27873401 GPN1 0.52 7.02 0.36 1.23e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 7.33 0.37 1.76e-12 Hip circumference adjusted for BMI; LUSC trans rs7824557 0.564 rs11781637 chr8:11214972 C/T cg06636001 chr8:8085503 FLJ10661 -0.57 -8.7 -0.43 1.57e-16 Retinal vascular caliber; LUSC cis rs453301 0.686 rs6748 chr8:8890802 C/T cg15556689 chr8:8085844 FLJ10661 -0.6 -9.63 -0.47 1.53e-19 Joint mobility (Beighton score); LUSC cis rs17095355 1.000 rs7067604 chr10:111734665 G/A cg00817464 chr10:111662876 XPNPEP1 -0.65 -7.91 -0.4 3.86e-14 Biliary atresia; LUSC cis rs73206853 0.686 rs7139314 chr12:110923871 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21783428 chr6:3118692 BPHL 0.74 6.12 0.32 2.62e-9 Cognitive performance; LUSC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 7.98 0.4 2.31e-14 Homoarginine levels; LUSC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg17385448 chr1:15911702 AGMAT 0.35 5.97 0.31 6.18e-9 Systolic blood pressure; LUSC cis rs1215050 0.740 rs783941 chr4:99008235 T/C cg05340658 chr4:99064831 C4orf37 -0.46 -7.16 -0.36 5.07e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg23649088 chr2:200775458 C2orf69 0.77 14.21 0.61 3.73e-36 Osteoporosis; LUSC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg20476274 chr7:133979776 SLC35B4 0.81 14.17 0.61 5.17e-36 Mean platelet volume; LUSC cis rs2455601 0.608 rs1368017 chr11:8867070 A/C cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -7.46 -0.38 7.49e-13 Schizophrenia; LUSC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg00343986 chr7:65444356 GUSB 0.38 5.71 0.3 2.46e-8 Aortic root size; LUSC cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg23173402 chr1:227635558 NA 0.6 7.14 0.36 5.98e-12 Major depressive disorder; LUSC cis rs68170813 0.641 rs12539895 chr7:107091849 C/A cg02696742 chr7:106810147 HBP1 -0.66 -9.66 -0.47 1.21e-19 Coronary artery disease; LUSC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.79 0.47 4.62e-20 Bipolar disorder; LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6867913 0.561 rs9324864 chr5:141469000 A/G cg23435118 chr5:141488016 NDFIP1 0.45 7.12 0.36 6.67e-12 Asthma; LUSC cis rs71017072 1 rs71017072 chr7:19794295 G/GA cg07541023 chr7:19748670 TWISTNB 0.6 6.57 0.34 1.91e-10 Rubella; LUSC cis rs4776059 0.761 rs12594964 chr15:52900208 G/A cg22715398 chr15:52968154 KIAA1370 0.66 8.37 0.42 1.57e-15 Schizophrenia; LUSC cis rs72781680 0.898 rs72798041 chr2:23953076 T/C cg20701182 chr2:24300061 SF3B14 0.75 7.31 0.37 1.94e-12 Lymphocyte counts; LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs865483 0.929 rs853215 chr17:35861133 A/G cg06716730 chr17:35851459 DUSP14 0.28 6.33 0.33 8.12e-10 Monocyte count; LUSC cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg01028140 chr2:1542097 TPO -0.37 -5.96 -0.31 6.44e-9 IgG glycosylation; LUSC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.03 0.31 4.27e-9 Lung cancer; LUSC cis rs6920965 0.507 rs12203025 chr6:126192034 C/T cg05901451 chr6:126070800 HEY2 -0.54 -7.77 -0.39 9.74e-14 High light scatter reticulocyte count; LUSC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.1e-30 Aortic root size; LUSC cis rs12421382 0.543 rs10890996 chr11:109328421 A/G cg11473876 chr11:109292803 C11orf87 -0.42 -6.61 -0.34 1.54e-10 Schizophrenia; LUSC cis rs2197308 0.728 rs7304305 chr12:37932990 T/C cg26384229 chr12:38710491 ALG10B -0.82 -13.55 -0.6 1.28e-33 Morning vs. evening chronotype; LUSC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg23711669 chr6:146136114 FBXO30 -0.94 -17.99 -0.7 4.38e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs9790314 0.936 rs466399 chr3:161091194 G/T cg03342759 chr3:160939853 NMD3 -0.48 -7.92 -0.4 3.49e-14 Morning vs. evening chronotype; LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg04234412 chr22:24373322 LOC391322 0.77 9.54 0.46 3e-19 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg24531977 chr5:56204891 C5orf35 -0.6 -8.96 -0.44 2.34e-17 Coronary artery disease; LUSC cis rs2324229 0.797 rs1180186 chr6:83968946 T/G cg08257003 chr6:84140564 ME1 0.33 7.71 0.39 1.42e-13 Platelet-derived growth factor BB levels; LUSC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg24468199 chr11:65410028 SIPA1 -0.54 -7.52 -0.38 4.99e-13 Blood pressure (age interaction); LUSC cis rs6977660 0.660 rs10269891 chr7:19816063 T/C cg07541023 chr7:19748670 TWISTNB 0.65 7.04 0.36 1.12e-11 Thyroid stimulating hormone; LUSC cis rs708547 0.836 rs781554 chr4:57717537 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.57 -6.9 -0.35 2.64e-11 Response to bleomycin (chromatid breaks); LUSC cis rs11098499 0.863 rs2306456 chr4:120472422 C/G cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9790314 0.846 rs4470535 chr3:160974468 G/A cg03342759 chr3:160939853 NMD3 -0.56 -9.58 -0.46 2.36e-19 Morning vs. evening chronotype; LUSC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.83 0.35 3.95e-11 Cystic fibrosis severity; LUSC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs1062746 0.544 rs3762182 chr16:87326113 A/G cg02258303 chr16:87377426 FBXO31 0.51 7.67 0.39 1.93e-13 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg08859206 chr1:53392774 SCP2 -0.43 -7.04 -0.36 1.09e-11 Monocyte count; LUSC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg25039879 chr17:56429692 SUPT4H1 0.72 9.75 0.47 6.09e-20 Cognitive test performance; LUSC cis rs10761482 1.000 rs10821720 chr10:62077056 A/C cg18175470 chr10:62150864 ANK3 -0.46 -6.36 -0.33 6.65e-10 Schizophrenia; LUSC cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs1957429 0.901 rs59876171 chr14:65384429 C/T cg23373153 chr14:65346875 NA -1.04 -11.35 -0.53 1.85e-25 Pediatric areal bone mineral density (radius); LUSC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg03676636 chr4:99064102 C4orf37 0.31 6.57 0.34 1.94e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs2486288 0.656 rs8039138 chr15:45551592 C/T cg09092052 chr15:45571596 NA 0.45 6.26 0.32 1.18e-9 Glomerular filtration rate; LUSC cis rs17270561 0.609 rs12663099 chr6:25739518 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs7771547 0.642 rs629560 chr6:36511391 A/G cg07856975 chr6:36356162 ETV7 0.36 6.31 0.33 8.95e-10 Platelet distribution width; LUSC cis rs977987 0.806 rs12448947 chr16:75462954 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs11997175 0.609 rs4733459 chr8:33663793 T/C ch.8.33884649F chr8:33765107 NA 0.4 6.14 0.32 2.31e-9 Body mass index; LUSC cis rs548181 0.611 rs1293672 chr11:125461034 A/G cg03464685 chr11:125439445 EI24 1.28 13.82 0.6 1.1e-34 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg06784218 chr1:46089804 CCDC17 0.5 9.91 0.48 1.76e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12912251 1.000 rs35024396 chr15:38989770 G/A cg01338139 chr15:38987640 C15orf53 -0.5 -6.9 -0.35 2.54e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs637571 0.510 rs4930320 chr11:65576788 C/G cg26695010 chr11:65641043 EFEMP2 0.46 6.68 0.34 1.02e-10 Eosinophil percentage of white cells; LUSC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.14 -0.49 3.12e-21 Developmental language disorder (linguistic errors); LUSC cis rs6845621 0.754 rs7685547 chr4:18878333 G/A cg12196642 chr4:18937545 NA -0.33 -6.0 -0.31 5.16e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs1814175 0.817 rs1851860 chr11:49861310 A/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.84 -0.81 6.6900000000000005e-78 Height; LUSC cis rs40363 1.000 rs37768 chr16:3514777 T/C cg21433313 chr16:3507492 NAT15 0.8 9.92 0.48 1.73e-20 Tuberculosis; LUSC cis rs61931739 0.635 rs1352208 chr12:33932543 T/C cg06521331 chr12:34319734 NA -0.4 -6.69 -0.34 9.58e-11 Morning vs. evening chronotype; LUSC trans rs1493916 0.721 rs4471760 chr18:31374233 G/A cg13755796 chr4:20253514 NA -0.42 -6.61 -0.34 1.48e-10 Life satisfaction; LUSC cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg06784218 chr1:46089804 CCDC17 0.49 9.49 0.46 4.67e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11785400 1.000 rs4518642 chr8:143737396 T/C cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.67e-17 Schizophrenia; LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg07507251 chr3:52567010 NT5DC2 0.35 6.85 0.35 3.63e-11 Bipolar disorder; LUSC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg27266060 chr8:22091797 NA 0.4 7.36 0.37 1.41e-12 Hypertriglyceridemia; LUSC cis rs1008375 1.000 rs2872958 chr4:17665032 A/G cg18681998 chr4:17616180 MED28 0.86 15.68 0.65 6.75e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs686320 1.000 rs72643572 chr11:65250967 A/G cg21890820 chr11:65308645 LTBP3 0.78 7.76 0.39 1.06e-13 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.29e-11 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.15e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2067615 0.599 rs10778508 chr12:107159405 A/G cg15890332 chr12:107067104 RFX4 -0.33 -5.97 -0.31 5.93e-9 Heart rate; LUSC cis rs365132 0.875 rs3923879 chr5:176355312 C/T cg25401027 chr5:176370377 UIMC1 0.35 5.72 0.3 2.36e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs11148252 0.532 rs9536262 chr13:53303074 A/C cg02158880 chr13:53174818 NA -0.57 -10.08 -0.48 5.03e-21 Lewy body disease; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -8.75 -0.43 1.09e-16 Lymphocyte counts; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -8.08 -0.4 1.18e-14 Bipolar disorder and schizophrenia; LUSC cis rs3540 0.597 rs10152221 chr15:91047664 A/G cg10434728 chr15:90938212 IQGAP1 -0.45 -9.13 -0.45 6.92e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg07959070 chr22:50026188 C22orf34 -0.29 -5.9 -0.31 9.09e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs738322 1.000 rs4381 chr22:38570791 T/C cg25457927 chr22:38595422 NA -0.42 -8.92 -0.44 3.05e-17 Cutaneous nevi; LUSC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg00343986 chr7:65444356 GUSB -0.42 -6.46 -0.33 3.61e-10 Aortic root size; LUSC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg15839431 chr19:19639596 YJEFN3 0.43 6.1 0.32 2.86e-9 Tonsillectomy; LUSC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg24675658 chr1:53192096 ZYG11B -0.72 -11.74 -0.54 6.94e-27 Monocyte count; LUSC cis rs7296418 0.699 rs11057219 chr12:123750073 T/C cg05973401 chr12:123451056 ABCB9 0.56 8.17 0.41 6.27e-15 Platelet count; LUSC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.18e-11 Developmental language disorder (linguistic errors); LUSC cis rs748404 0.650 rs518261 chr15:43573429 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.57 8.84 0.44 5.69e-17 Lung cancer; LUSC cis rs57590327 0.503 rs13075250 chr3:81907952 T/C cg07356753 chr3:81810745 GBE1 -0.65 -10.37 -0.49 4.88e-22 Extraversion; LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg14789911 chr21:47582049 C21orf56 -0.39 -6.23 -0.32 1.42e-9 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.18 0.55 1.77e-28 Motion sickness; LUSC cis rs11030122 0.702 rs17081 chr11:3987830 A/G cg18678763 chr11:4115507 RRM1 0.47 6.09 0.32 3.11e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg16339924 chr4:17578868 LAP3 0.58 9.05 0.44 1.18e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg21699342 chr2:239360505 ASB1 0.6 11.22 0.52 5.27e-25 Multiple system atrophy; LUSC cis rs7149337 0.869 rs10137481 chr14:51694614 C/T cg23942311 chr14:51606299 NA 0.48 10.51 0.5 1.65e-22 Cancer; LUSC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg24154853 chr7:158122151 PTPRN2 0.45 8.8 0.43 7.55e-17 Calcium levels; LUSC cis rs8058578 1.000 rs6565197 chr16:30706477 T/C cg02466173 chr16:30829666 NA -0.59 -10.83 -0.51 1.28e-23 Multiple myeloma; LUSC cis rs4243830 0.737 rs6692747 chr1:6610049 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.97 9.63 0.47 1.51e-19 Body mass index; LUSC cis rs2635047 0.967 rs9960264 chr18:44606996 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 7.33 0.37 1.72e-12 Educational attainment; LUSC cis rs4285028 0.699 rs1344279 chr3:121615679 G/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.48 -0.46 4.96e-19 Multiple sclerosis; LUSC cis rs9788682 0.748 rs667282 chr15:78863472 T/C cg06917634 chr15:78832804 PSMA4 -0.53 -6.59 -0.34 1.68e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 6.69 0.34 9.24e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs67539049 1.000 rs60320871 chr8:11297549 C/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.38 -5.81 -0.3 1.43e-8 Itch intensity from mosquito bite; LUSC cis rs6977940 0.730 rs73033432 chr7:2891037 C/T cg19346786 chr7:2764209 NA 0.53 5.76 0.3 1.93e-8 White matter integrity; LUSC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg13206674 chr6:150067644 NUP43 0.61 9.59 0.46 2.18e-19 Lung cancer; LUSC cis rs1577917 0.958 rs12190603 chr6:86475718 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.38 -0.33 5.78e-10 Response to antipsychotic treatment; LUSC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg26408565 chr15:76604113 ETFA -0.5 -8.03 -0.4 1.68e-14 Blood metabolite levels; LUSC cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg24296786 chr1:45957014 TESK2 -0.47 -6.94 -0.36 2.01e-11 High light scatter reticulocyte count; LUSC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC trans rs656319 0.669 rs56279061 chr8:9873980 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.2 -0.37 3.94e-12 Myopia (pathological); LUSC cis rs4285028 0.948 rs12497349 chr3:121708517 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -9.18 -0.45 4.76e-18 Multiple sclerosis; LUSC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.54 -7.33 -0.37 1.76e-12 Mean platelet volume; LUSC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg05861140 chr6:150128134 PCMT1 -0.45 -7.17 -0.37 4.83e-12 Lung cancer; LUSC cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg08213375 chr14:104286397 PPP1R13B 0.52 10.48 0.5 2.03e-22 Schizophrenia; LUSC cis rs804280 0.564 rs4639 chr8:11644751 A/G cg26752888 chr8:11627280 NEIL2 -0.41 -6.53 -0.34 2.42e-10 Myopia (pathological); LUSC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg22433210 chr17:43662623 NA -0.72 -10.25 -0.49 1.34e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs9902453 1.000 rs9890205 chr17:28382704 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.89 -0.44 3.97e-17 Coffee consumption (cups per day); LUSC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg03684893 chr10:554711 DIP2C 0.35 6.31 0.33 8.64e-10 Psychosis in Alzheimer's disease; LUSC cis rs826838 0.651 rs1843896 chr12:38612913 G/C cg26384229 chr12:38710491 ALG10B 0.77 12.06 0.55 4.9e-28 Heart rate; LUSC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg20203395 chr5:56204925 C5orf35 -0.5 -7.38 -0.37 1.28e-12 Coronary artery disease; LUSC cis rs2439831 0.850 rs28413704 chr15:44148427 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.78 6.92 0.35 2.25e-11 Lung cancer in ever smokers; LUSC cis rs6967385 0.538 rs10275154 chr7:12355002 T/C cg06484146 chr7:12443880 VWDE 0.5 7.43 0.38 9.08e-13 Response to taxane treatment (placlitaxel); LUSC cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg17366294 chr4:99064904 C4orf37 0.59 10.3 0.49 8.78e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg17366294 chr4:99064904 C4orf37 0.55 9.6 0.47 1.98e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4280164 0.945 rs11158635 chr14:24776769 G/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.6 -7.11 -0.36 7.27e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs4820539 1.000 rs4822358 chr22:23474795 A/G cg14186256 chr22:23484241 RTDR1 0.95 17.95 0.7 6.57e-51 Bone mineral density; LUSC cis rs7106204 1.000 rs7110656 chr11:24216034 G/T ch.11.24196551F chr11:24239977 NA 0.99 9.66 0.47 1.26e-19 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6987853 0.830 rs9643888 chr8:42352007 T/C cg09913449 chr8:42400586 C8orf40 -0.42 -6.85 -0.35 3.49e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg20135002 chr11:47629003 NA -0.48 -7.36 -0.37 1.4e-12 Subjective well-being; LUSC cis rs3774830 0.685 rs73212741 chr4:5464450 G/C cg26943120 chr4:5472116 STK32B 0.29 5.8 0.3 1.57e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs8114671 0.562 rs2378292 chr20:33485178 T/C cg07148914 chr20:33460835 GGT7 0.56 8.46 0.42 8.69e-16 Height; LUSC cis rs10740039 0.516 rs1975443 chr10:62321342 G/A cg18175470 chr10:62150864 ANK3 -0.47 -6.95 -0.36 1.97e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.86 -0.35 3.38e-11 Monocyte percentage of white cells; LUSC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg11859384 chr17:80120422 CCDC57 0.38 5.96 0.31 6.52e-9 Life satisfaction; LUSC cis rs734999 0.588 rs2764848 chr1:2530694 G/A cg18854424 chr1:2615690 NA -0.5 -9.86 -0.47 2.74e-20 Ulcerative colitis; LUSC cis rs9326248 0.861 rs4938348 chr11:117021877 G/C cg26566898 chr11:117069891 TAGLN 0.37 5.86 0.31 1.11e-8 Blood protein levels; LUSC cis rs12291225 0.545 rs11023187 chr11:14345559 T/G cg19336497 chr11:14380999 RRAS2 -0.61 -14.16 -0.61 5.7e-36 Sense of smell; LUSC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 11.18 0.52 7.05e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs61931739 0.534 rs1912773 chr12:34097401 T/C cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.41 0.38 1.07e-12 Melanoma; LUSC cis rs10911232 0.507 rs12037585 chr1:183000041 G/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs4788815 1.000 rs4788815 chr16:71634811 A/T cg00732059 chr16:71740210 PHLPP2 0.38 5.91 0.31 8.27e-9 Metabolite levels; LUSC cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.48 7.83 0.39 6.55e-14 Vitiligo; LUSC cis rs1577917 0.804 rs2786854 chr6:86668740 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.26 -0.32 1.21e-9 Response to antipsychotic treatment; LUSC cis rs870825 0.616 rs2310110 chr4:185647902 G/A cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg23158103 chr7:148848205 ZNF398 -0.47 -7.71 -0.39 1.5e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg04234412 chr22:24373322 LOC391322 0.85 13.91 0.61 5e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg23102388 chr7:1867652 MAD1L1 -0.31 -5.93 -0.31 7.67e-9 Bipolar disorder and schizophrenia; LUSC cis rs7248779 1.000 rs7248779 chr19:2403564 G/T cg22729335 chr19:2427816 TIMM13 -0.48 -7.91 -0.4 3.82e-14 Cortisol levels (saliva); LUSC cis rs950776 0.593 rs6495306 chr15:78865893 C/T cg22563815 chr15:78856949 CHRNA5 -0.25 -6.03 -0.31 4.42e-9 Sudden cardiac arrest; LUSC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg00645731 chr22:42541494 CYP2D7P1 0.28 5.65 0.3 3.44e-8 Cognitive function; LUSC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -24.54 -0.8 9.72e-77 Height; LUSC cis rs61931739 0.927 rs1906135 chr12:34038103 C/A cg06521331 chr12:34319734 NA 0.4 6.61 0.34 1.48e-10 Morning vs. evening chronotype; LUSC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg15605315 chr1:45957053 TESK2 0.46 7.21 0.37 3.78e-12 High light scatter reticulocyte count; LUSC cis rs2692947 0.770 rs12471925 chr2:96555522 C/A cg23100626 chr2:96804247 ASTL 0.3 7.03 0.36 1.17e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg09365446 chr1:150670422 GOLPH3L 0.52 7.95 0.4 2.81e-14 Melanoma; LUSC trans rs8072100 0.935 rs78737171 chr17:45668760 A/T cg04995722 chr7:26192034 NFE2L3 0.37 6.15 0.32 2.24e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs7824557 0.583 rs6601585 chr8:11233659 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.13 -0.41 8.27e-15 Retinal vascular caliber; LUSC trans rs11039798 0.687 rs11499938 chr11:48957297 G/A cg15704280 chr7:45808275 SEPT13 0.78 7.57 0.38 3.79e-13 Axial length; LUSC trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg23505145 chr19:12996616 KLF1 0.64 10.98 0.51 3.62e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg26384229 chr12:38710491 ALG10B 0.86 14.0 0.61 2.4e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs9527 0.614 rs11191589 chr10:104930382 T/C cg05855489 chr10:104503620 C10orf26 0.52 7.88 0.4 4.72e-14 Arsenic metabolism; LUSC cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg17143192 chr8:8559678 CLDN23 0.63 9.07 0.44 1.02e-17 Obesity-related traits; LUSC trans rs7726839 0.540 rs3749618 chr5:602650 A/G cg25482853 chr8:67687455 SGK3 1.11 15.56 0.65 1.88e-41 Obesity-related traits; LUSC cis rs3806843 0.576 rs246046 chr5:140329264 T/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg14004847 chr7:1930337 MAD1L1 -0.57 -8.87 -0.44 4.51e-17 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg11764359 chr7:65958608 NA -0.68 -10.96 -0.51 4.32e-24 Aortic root size; LUSC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 12.1 0.55 3.43e-28 Hip circumference adjusted for BMI; LUSC cis rs12545109 0.800 rs2582404 chr8:57387368 C/T cg09654669 chr8:57350985 NA -0.51 -6.81 -0.35 4.61e-11 Obesity-related traits; LUSC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.6 -8.89 -0.44 3.97e-17 Menarche (age at onset); LUSC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.62 9.39 0.46 9.41e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1335645 0.570 rs12406191 chr1:111639491 C/G cg00321911 chr1:111669324 DRAM2 -0.59 -6.29 -0.33 9.92e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs983392 0.836 rs17602572 chr11:59948374 C/G cg20284999 chr11:59952153 MS4A6A -0.39 -6.57 -0.34 1.97e-10 Alzheimer's disease (late onset); LUSC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg06671706 chr8:8559999 CLDN23 0.45 6.08 0.32 3.32e-9 Obesity-related traits; LUSC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg18876405 chr7:65276391 NA -0.7 -12.66 -0.57 2.88e-30 Aortic root size; LUSC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg09650180 chr20:62225654 GMEB2 -0.66 -9.63 -0.47 1.51e-19 Glioblastoma; LUSC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg20891558 chr2:74357851 NA 0.81 12.76 0.57 1.21e-30 Gestational age at birth (maternal effect); LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs7474896 0.583 rs12776092 chr10:38015795 G/C cg25427524 chr10:38739819 LOC399744 -0.5 -6.53 -0.34 2.48e-10 Obesity (extreme); LUSC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg05368731 chr17:41323189 NBR1 -0.85 -13.92 -0.61 4.79e-35 Menopause (age at onset); LUSC cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg23711669 chr6:146136114 FBXO30 -0.82 -14.68 -0.63 5.49e-38 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16338201 chr18:9914940 VAPA -0.39 -5.99 -0.31 5.54e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.75 0.51 2.31e-23 Homoarginine levels; LUSC cis rs10089 0.904 rs2195921 chr5:127489754 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.85 11.7 0.54 9.61e-27 Ileal carcinoids; LUSC cis rs1801251 0.963 rs283481 chr2:233648091 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.16 0.32 2.14e-9 Coronary artery disease; LUSC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg26695010 chr11:65641043 EFEMP2 0.42 5.81 0.3 1.42e-8 Breast cancer; LUSC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg05890377 chr2:74357713 NA 0.69 12.22 0.56 1.25e-28 Gestational age at birth (maternal effect); LUSC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg19077165 chr18:44547161 KATNAL2 -0.43 -6.48 -0.33 3.31e-10 Personality dimensions; LUSC cis rs1358748 0.522 rs4655514 chr1:67550921 G/C cg02640540 chr1:67518911 SLC35D1 0.62 6.4 0.33 5.25e-10 Tuberculosis; LUSC cis rs28785552 0.931 rs10406850 chr19:53240807 A/C cg22067481 chr19:53234126 ZNF611 -0.53 -7.35 -0.37 1.55e-12 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs35123781 1.000 rs9687282 chr5:139065988 T/G cg00976381 chr5:138713954 SLC23A1 -0.38 -5.74 -0.3 2.17e-8 Schizophrenia; LUSC cis rs7172677 1.000 rs4886658 chr15:75414536 A/C cg14664628 chr15:75095509 CSK -0.45 -5.8 -0.3 1.51e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9467773 0.595 rs13207371 chr6:26591074 G/A cg05738196 chr6:26577821 NA 0.8 15.21 0.64 4.74e-40 Intelligence (multi-trait analysis); LUSC cis rs7819412 0.875 rs11250121 chr8:11060311 A/C cg27411982 chr8:10470053 RP1L1 -0.4 -6.01 -0.31 4.93e-9 Triglycerides; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC cis rs477692 1.000 rs580745 chr10:131414401 G/A cg11019008 chr10:131425282 MGMT 0.42 6.4 0.33 5.19e-10 Response to temozolomide; LUSC cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 13.45 0.59 3.03e-33 Chronic sinus infection; LUSC cis rs600626 0.578 rs11821808 chr11:75451187 C/T cg24262691 chr11:75473276 NA 0.44 5.91 0.31 8.25e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg20887711 chr4:1340912 KIAA1530 0.39 5.67 0.3 3.16e-8 Obesity-related traits; LUSC cis rs7605827 0.930 rs4668446 chr2:15516020 C/T cg19274914 chr2:15703543 NA 0.47 9.07 0.44 1.03e-17 Educational attainment (years of education); LUSC cis rs13088318 0.504 rs55759062 chr3:101202152 C/T cg12386194 chr3:101231763 SENP7 0.38 5.77 0.3 1.82e-8 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7712401 0.601 rs404442 chr5:122344931 C/T cg19077854 chr5:122220652 SNX24 -0.42 -9.19 -0.45 4.44e-18 Mean platelet volume; LUSC cis rs7927771 0.524 rs7123952 chr11:47852057 T/C cg20307385 chr11:47447363 PSMC3 0.45 6.55 0.34 2.17e-10 Subjective well-being; LUSC cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs12701220 0.542 rs6957866 chr7:1111674 G/A cg00990874 chr7:1149470 C7orf50 -0.51 -5.92 -0.31 8.18e-9 Bronchopulmonary dysplasia; LUSC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg21856205 chr7:94953877 PON1 -0.36 -5.75 -0.3 2.06e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs72772090 0.539 rs3335 chr5:96115070 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -6.56 -0.34 2.04e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg20476274 chr7:133979776 SLC35B4 0.87 16.89 0.68 1.02e-46 Mean platelet volume; LUSC cis rs11155671 0.530 rs7756850 chr6:150212596 G/C cg07701084 chr6:150067640 NUP43 0.48 7.06 0.36 9.88e-12 Testicular germ cell tumor; LUSC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg18512352 chr11:47633146 NA -0.43 -9.2 -0.45 4.07e-18 Subjective well-being; LUSC trans rs9951602 0.512 rs1599633 chr18:76643526 T/C cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs6541297 0.645 rs2296065 chr1:230301776 G/A cg20703242 chr1:230279135 GALNT2 0.48 5.73 0.3 2.2e-8 Coronary artery disease; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 5.04e-15 Alzheimer's disease; LUSC cis rs131777 0.577 rs5770928 chr22:51029091 G/C cg25309564 chr22:51001381 C22orf41 0.45 6.21 0.32 1.58e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs11167764 1.000 rs7730511 chr5:141480418 T/C cg08523384 chr5:141488047 NDFIP1 -0.51 -7.42 -0.38 9.93e-13 Crohn's disease; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg08280861 chr8:58055591 NA 0.58 6.74 0.35 6.86e-11 Developmental language disorder (linguistic errors); LUSC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.24 -0.41 3.87e-15 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.03 0.44 1.44e-17 Lobe attachment (rater-scored or self-reported); LUSC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.46 0.67 5.21e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs62027291 0.950 rs62027298 chr15:77282250 C/T cg26408565 chr15:76604113 ETFA 0.51 6.12 0.32 2.65e-9 Plateletcrit; LUSC cis rs1371867 0.846 rs1660324 chr8:101281271 C/T cg00191853 chr8:101177733 SPAG1 -0.39 -6.32 -0.33 8.17e-10 Atrioventricular conduction; LUSC cis rs16866061 0.515 rs114968850 chr2:225352461 C/G cg12698349 chr2:225449008 CUL3 0.99 20.1 0.74 1.78e-59 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs921968 0.540 rs7582329 chr2:219620909 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC trans rs10432489 0.708 rs12328545 chr2:181771545 T/A cg11196870 chr8:41386826 GINS4 0.93 6.32 0.33 8.44e-10 QT interval; LUSC cis rs9650315 0.704 rs67742458 chr8:57170647 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.75 0.39 1.09e-13 Height; LUSC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg18479299 chr3:125709523 NA -0.51 -5.83 -0.3 1.33e-8 Blood pressure (smoking interaction); LUSC cis rs2073300 0.609 rs2281428 chr20:23400050 C/T cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.15e-10 Arsenic metabolism; LUSC cis rs9309473 0.583 rs6709853 chr2:73576065 T/A cg20560298 chr2:73613845 ALMS1 -0.51 -7.33 -0.37 1.7e-12 Metabolite levels; LUSC cis rs3740540 0.530 rs2362507 chr10:126290820 A/G cg04949429 chr10:126290192 LHPP 0.36 7.65 0.39 2.21e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs6987853 0.966 rs2084709 chr8:42423190 A/G cg09913449 chr8:42400586 C8orf40 0.51 8.84 0.44 5.49e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg12463550 chr7:65579703 CRCP -0.54 -8.06 -0.4 1.41e-14 Aortic root size; LUSC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg07959070 chr22:50026188 C22orf34 -0.36 -7.39 -0.37 1.18e-12 Monocyte count;Monocyte percentage of white cells; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02628353 chr7:26241504 HNRNPA2B1;CBX3 0.44 6.4 0.33 5.39e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17401966 0.540 rs10864452 chr1:10395683 G/T cg17425144 chr1:10567563 PEX14 -0.34 -5.96 -0.31 6.31e-9 Hepatocellular carcinoma; LUSC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg05973401 chr12:123451056 ABCB9 0.52 7.01 0.36 1.32e-11 Neutrophil percentage of white cells; LUSC cis rs1358748 0.522 rs6701962 chr1:67564857 A/T cg02640540 chr1:67518911 SLC35D1 0.68 6.85 0.35 3.53e-11 Tuberculosis; LUSC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg21138405 chr5:131827807 IRF1 -0.34 -6.04 -0.31 4.22e-9 Breast cancer;Mosquito bite size; LUSC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg18512352 chr11:47633146 NA -0.46 -9.51 -0.46 3.86e-19 Subjective well-being; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs7586879 0.663 rs6760328 chr2:25077991 T/C cg01884057 chr2:25150051 NA 0.35 7.05 0.36 1.01e-11 Body mass index; LUSC cis rs778371 0.697 rs4973564 chr2:233718440 A/G cg08000102 chr2:233561755 GIGYF2 -0.81 -13.88 -0.6 6.5e-35 Schizophrenia; LUSC cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14240646 chr10:27532245 ACBD5 -0.66 -7.89 -0.4 4.35e-14 Breast cancer; LUSC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 7.59 0.38 3.22e-13 Initial pursuit acceleration; LUSC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg08859206 chr1:53392774 SCP2 0.39 6.52 0.34 2.58e-10 Monocyte count; LUSC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg12310025 chr6:25882481 NA -0.49 -8.31 -0.41 2.45e-15 Intelligence (multi-trait analysis); LUSC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg17554472 chr22:41940697 POLR3H 0.47 5.73 0.3 2.22e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9303401 0.659 rs16943176 chr17:56769887 G/A cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 13.83 0.6 1.06e-34 Platelet count; LUSC cis rs1595825 0.891 rs6707521 chr2:198713231 A/G cg10547527 chr2:198650123 BOLL 0.5 5.87 0.31 1.04e-8 Ulcerative colitis; LUSC cis rs2227564 0.794 rs2688607 chr10:75663736 C/T cg17411546 chr10:75410026 SYNPO2L 0.45 5.69 0.3 2.78e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9392556 0.829 rs633290 chr6:4114788 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 0.35 6.29 0.33 1.02e-9 Blood metabolite levels; LUSC cis rs10752881 1.000 rs10752883 chr1:182980963 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs7223966 1.000 rs6504173 chr17:61735056 T/C cg05941027 chr17:61774174 LIMD2 0.21 5.79 0.3 1.62e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg01475377 chr6:109611718 NA -0.42 -7.6 -0.38 3.11e-13 Reticulocyte fraction of red cells; LUSC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg19346786 chr7:2764209 NA 0.47 8.25 0.41 3.57e-15 Height; LUSC cis rs7833790 0.724 rs6473299 chr8:82676936 A/G cg02079420 chr8:82753780 SNX16 0.39 5.91 0.31 8.33e-9 Diastolic blood pressure; LUSC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg08499158 chr17:42289980 UBTF -0.53 -8.52 -0.42 5.5e-16 Total body bone mineral density; LUSC cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg08213375 chr14:104286397 PPP1R13B -0.53 -10.12 -0.48 3.59e-21 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11201273 chr8:38088865 DDHD2 -0.4 -6.32 -0.33 8.46e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs344364 0.602 rs12325217 chr16:1887108 A/T cg00564555 chr16:1970112 NA -0.35 -5.97 -0.31 6.19e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7189233 0.531 rs1131220 chr16:53503934 G/A cg09728985 chr16:53543985 NA -0.33 -6.18 -0.32 1.91e-9 Intelligence (multi-trait analysis); LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg13453750 chr1:205783389 SLC41A1 0.34 6.75 0.35 6.7e-11 Menarche (age at onset); LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.66 0.63 6.18e-38 Platelet count; LUSC cis rs61931739 0.534 rs73103090 chr12:34098801 C/T cg06521331 chr12:34319734 NA -0.47 -7.77 -0.39 9.91e-14 Morning vs. evening chronotype; LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg08677398 chr8:58056175 NA 0.53 6.5 0.33 2.97e-10 Developmental language disorder (linguistic errors); LUSC cis rs977987 0.843 rs12149063 chr16:75451758 G/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.65 -0.34 1.23e-10 Dupuytren's disease; LUSC cis rs2777491 0.574 rs11858812 chr15:41731550 G/A cg18705301 chr15:41695430 NDUFAF1 -1.02 -20.93 -0.75 9.51e-63 Ulcerative colitis; LUSC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg06634786 chr22:41940651 POLR3H 0.52 5.89 0.31 9.31e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg07677032 chr17:61819896 STRADA 0.52 8.78 0.43 8.47e-17 Prudent dietary pattern; LUSC trans rs11148252 0.740 rs9596643 chr13:52912380 G/A cg18335740 chr13:41363409 SLC25A15 -0.55 -8.46 -0.42 8.2e-16 Lewy body disease; LUSC cis rs9325144 0.560 rs10506125 chr12:39120287 C/T cg26384229 chr12:38710491 ALG10B 0.64 10.59 0.5 8.6e-23 Morning vs. evening chronotype; LUSC cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs7605827 0.930 rs11674824 chr2:15537429 G/A cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 5.78 0.3 1.73e-8 Rheumatoid arthritis; LUSC cis rs500891 0.553 rs12197490 chr6:84153255 G/A cg08257003 chr6:84140564 ME1 0.37 9.19 0.45 4.35e-18 Platelet-derived growth factor BB levels; LUSC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg23758822 chr17:41437982 NA 1.03 20.09 0.74 2.12e-59 Menopause (age at onset); LUSC cis rs9660992 0.573 rs12140422 chr1:205187981 G/A cg21545522 chr1:205238299 TMCC2 0.49 9.13 0.45 6.85e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.24 -0.32 1.32e-9 Developmental language disorder (linguistic errors); LUSC cis rs2262909 0.962 rs408687 chr19:22231123 T/C cg11619707 chr19:22235551 ZNF257 -0.38 -5.7 -0.3 2.7e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs11098499 0.754 rs10213267 chr4:120239074 A/G cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs10979 0.931 rs9484771 chr6:143896897 T/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg24110177 chr3:50126178 RBM5 0.65 11.69 0.54 1.1e-26 Body mass index; LUSC cis rs1784581 0.706 rs9346895 chr6:162431168 T/C cg17173639 chr6:162384350 PARK2 0.66 11.76 0.54 5.88e-27 Itch intensity from mosquito bite; LUSC cis rs1395 0.925 rs1659701 chr2:27414877 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.4 -6.68 -0.34 9.89e-11 Blood metabolite levels; LUSC cis rs7829975 0.606 rs891570 chr8:8794454 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.88 -0.35 2.88e-11 Mood instability; LUSC trans rs7893279 0.822 rs11014186 chr10:18714473 A/T cg01840055 chr3:141338555 NA 0.5 6.04 0.31 4.15e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2625529 0.701 rs2306490 chr15:72227837 A/G cg16672083 chr15:72433130 SENP8 -0.52 -7.51 -0.38 5.54e-13 Red blood cell count; LUSC cis rs9527 1.000 rs4919690 chr10:104616500 C/T cg05855489 chr10:104503620 C10orf26 -0.54 -7.53 -0.38 4.76e-13 Arsenic metabolism; LUSC cis rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05901451 chr6:126070800 HEY2 0.76 12.41 0.56 2.33e-29 Endometrial cancer; LUSC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg06112835 chr11:68658793 MRPL21 0.52 7.95 0.4 2.82e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.91 0.4 3.77e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs12310956 0.510 rs1386936 chr12:33875369 G/A cg26384229 chr12:38710491 ALG10B 0.56 8.61 0.43 2.98e-16 Morning vs. evening chronotype; LUSC cis rs6500395 1.000 rs6500402 chr16:48687354 C/T cg04672837 chr16:48644449 N4BP1 0.46 6.97 0.36 1.7e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10464366 0.560 rs12672089 chr7:39132816 G/A cg20302533 chr7:39170763 POU6F2 0.49 7.83 0.39 6.63e-14 IgG glycosylation; LUSC cis rs9457247 0.765 rs9457256 chr6:167436461 T/C cg25258033 chr6:167368657 RNASET2 0.43 6.74 0.35 6.76e-11 Crohn's disease; LUSC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg03806693 chr22:41940476 POLR3H 0.88 12.29 0.56 7.03e-29 Vitiligo; LUSC cis rs644799 0.544 rs1150360 chr11:95512060 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.32 0.45 1.58e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg11764359 chr7:65958608 NA 0.55 7.39 0.37 1.17e-12 Aortic root size; LUSC cis rs6545883 0.894 rs4672423 chr2:61435275 C/T cg15711740 chr2:61764176 XPO1 0.46 7.2 0.37 3.94e-12 Tuberculosis; LUSC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg20295408 chr7:1910781 MAD1L1 0.4 5.74 0.3 2.12e-8 Bipolar disorder and schizophrenia; LUSC cis rs73129298 0.551 rs57655671 chr20:48598089 G/T cg25655593 chr20:48599521 SNAI1 0.59 6.37 0.33 6.36e-10 Inflammatory skin disease; LUSC trans rs7647973 0.710 rs9869120 chr3:49624065 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 7e-13 Menarche (age at onset); LUSC cis rs734999 0.549 rs2764840 chr1:2529437 C/T cg18854424 chr1:2615690 NA -0.52 -10.6 -0.5 8.29e-23 Ulcerative colitis; LUSC cis rs7098414 0.511 rs7916349 chr10:82152638 G/A cg00277334 chr10:82204260 NA -0.59 -9.81 -0.47 4.05e-20 Post bronchodilator FEV1; LUSC cis rs10504229 0.680 rs11777459 chr8:58044241 A/T cg11062466 chr8:58055876 NA 0.54 6.89 0.35 2.84e-11 Developmental language disorder (linguistic errors); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg17652818 chr12:56727926 PAN2 0.45 6.29 0.33 9.67e-10 Mosquito bite size; LUSC cis rs983392 0.709 rs11826180 chr11:59991333 T/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.97 -0.31 6.15e-9 Alzheimer's disease (late onset); LUSC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg18132916 chr6:79620363 NA -0.39 -5.99 -0.31 5.41e-9 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg06008330 chr7:65541103 ASL -0.4 -6.27 -0.32 1.13e-9 Aortic root size; LUSC cis rs1843834 0.898 rs2014887 chr2:225520082 A/G cg22455342 chr2:225449267 CUL3 0.44 6.04 0.31 4.08e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs911119 0.913 rs6048928 chr20:23585988 A/G cg16589663 chr20:23618590 CST3 0.62 7.67 0.39 1.89e-13 Chronic kidney disease; LUSC cis rs61990749 0.597 rs10148373 chr14:78280199 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.68 6.79 0.35 5.15e-11 Fibroblast growth factor basic levels; LUSC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg05425664 chr17:57184151 TRIM37 0.53 7.83 0.39 6.59e-14 Intelligence (multi-trait analysis); LUSC cis rs897984 0.683 rs13337900 chr16:30822409 G/A cg00531865 chr16:30841666 NA -0.33 -6.02 -0.31 4.51e-9 Dementia with Lewy bodies; LUSC cis rs12618769 0.652 rs2230388 chr2:99193496 C/T cg10123293 chr2:99228465 UNC50 0.46 7.47 0.38 7.17e-13 Bipolar disorder; LUSC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26326168 chr12:133405726 GOLGA3 0.43 7.11 0.36 7.02e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7903847 0.642 rs9888026 chr10:99159869 G/T cg08345082 chr10:99160200 RRP12 0.33 6.67 0.34 1.05e-10 Granulocyte percentage of myeloid white cells; LUSC trans rs7824557 0.564 rs4631424 chr8:11236809 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.47 -0.38 7.29e-13 Retinal vascular caliber; LUSC cis rs9814567 1.000 rs2056603 chr3:134312749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2204008 0.657 rs8186888 chr12:38334260 T/G cg26384229 chr12:38710491 ALG10B 0.68 10.32 0.49 7.51e-22 Bladder cancer; LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg03354898 chr7:1950403 MAD1L1 -0.37 -7.22 -0.37 3.48e-12 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg08742575 chr21:47604166 C21orf56 -0.48 -7.36 -0.37 1.43e-12 Testicular germ cell tumor; LUSC cis rs8017423 0.967 rs3825662 chr14:90723152 A/G cg04374321 chr14:90722782 PSMC1 0.75 12.04 0.55 5.52e-28 Mortality in heart failure; LUSC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs68170813 0.559 rs79978998 chr7:106845482 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.82 -0.47 3.71e-20 Coronary artery disease; LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg04518342 chr5:131593106 PDLIM4 0.42 7.25 0.37 2.83e-12 Breast cancer; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg11843238 chr5:131593191 PDLIM4 0.4 6.66 0.34 1.16e-10 Acylcarnitine levels; LUSC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.83 -0.47 3.34e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs2268241 0.938 rs9978166 chr21:34770516 A/G cg14850771 chr21:34775459 IFNGR2 1.0 12.62 0.57 4.07e-30 Obesity-related traits; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.71 -12.08 -0.55 4.08e-28 Prudent dietary pattern; LUSC cis rs11626933 1.000 rs11621007 chr14:90743967 G/A cg14092571 chr14:90743983 NA -0.9 -18.84 -0.72 1.79e-54 Gut microbiota (bacterial taxa); LUSC trans rs1814175 0.645 rs28549248 chr11:50042740 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs7582180 0.629 rs2309796 chr2:100954385 C/T cg12002119 chr2:101014098 CHST10 0.35 5.87 0.31 1.04e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.92 0.48 1.76e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7561273 0.561 rs35268318 chr2:24352824 A/T cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs11190604 1.000 rs7079756 chr10:102302105 G/A cg07080220 chr10:102295463 HIF1AN 0.68 9.42 0.46 7.78e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6500602 0.727 rs11076836 chr16:4569331 G/A cg08645402 chr16:4508243 NA 0.53 8.95 0.44 2.43e-17 Schizophrenia; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18404041 chr3:52824283 ITIH1 0.46 8.83 0.44 5.89e-17 Electroencephalogram traits; LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg00814883 chr7:100076585 TSC22D4 -0.66 -8.64 -0.43 2.36e-16 Platelet count; LUSC cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg03146154 chr1:46216737 IPP 0.51 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.7 -0.3 2.68e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg27121462 chr16:89883253 FANCA 0.55 8.87 0.44 4.58e-17 Vitiligo; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23250587 chr7:150929681 CHPF2 -0.42 -6.4 -0.33 5.27e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg00155535 chr12:132671473 NA 0.39 6.46 0.33 3.78e-10 Anti-saccade response; LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg27535305 chr1:53392650 SCP2 0.4 7.49 0.38 6.1e-13 Monocyte count; LUSC cis rs7180079 1.000 rs4238425 chr15:64671193 C/A cg02848875 chr15:64387786 SNX1 0.42 5.74 0.3 2.11e-8 Monocyte count; LUSC cis rs4499344 0.730 rs434020 chr19:33104070 C/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg16362232 chr11:430036 ANO9 0.62 8.11 0.41 9.85e-15 Body mass index; LUSC cis rs1797885 0.651 rs1552484 chr3:12580246 C/G cg09856107 chr3:12701776 RAF1 -0.33 -5.92 -0.31 8.11e-9 Immature fraction of reticulocytes; LUSC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg13298116 chr11:62369859 EML3;MTA2 0.59 9.56 0.46 2.67e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13242816 1.000 rs35800921 chr7:116124041 G/A cg16553024 chr7:116138462 CAV2 -0.52 -5.68 -0.3 2.89e-8 P wave duration; LUSC trans rs71327718 1 rs71327718 chr3:125592857 C/G cg07211511 chr3:129823064 LOC729375 -1.06 -12.97 -0.58 2.03e-31 Metabolite levels (HVA/5-HIAA ratio); LUSC cis rs7917772 0.560 rs7912339 chr10:104373758 G/C cg05855489 chr10:104503620 C10orf26 -0.48 -7.35 -0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8141797 0.502 rs12484381 chr22:24577121 G/C cg00411358 chr22:24577142 SUSD2 -0.5 -5.84 -0.3 1.23e-8 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14049380 chr3:52805078 NEK4 -0.42 -6.19 -0.32 1.78e-9 Electrocardiographic conduction measures; LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs4930103 0.590 rs3809101 chr11:1967271 C/T cg18032502 chr11:1949113 TNNT3 0.32 5.68 0.3 2.99e-8 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs35883536 0.647 rs34195036 chr1:101040429 C/A cg06223162 chr1:101003688 GPR88 -0.48 -9.15 -0.45 5.79e-18 Monocyte count; LUSC cis rs7223966 1.000 rs8077265 chr17:61732727 A/G cg05941027 chr17:61774174 LIMD2 0.21 5.79 0.3 1.62e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10782582 0.592 rs7513194 chr1:76382664 A/C cg10523679 chr1:76189770 ACADM 0.45 6.46 0.33 3.72e-10 Daytime sleep phenotypes; LUSC cis rs3925075 0.903 rs36100148 chr16:31345023 C/T cg02846316 chr16:31340340 ITGAM 0.35 6.53 0.34 2.48e-10 IgA nephropathy; LUSC cis rs6977660 0.714 rs9969171 chr7:19827328 T/C cg05791153 chr7:19748676 TWISTNB 0.65 6.58 0.34 1.82e-10 Thyroid stimulating hormone; LUSC cis rs738322 0.805 rs11570734 chr22:38518622 A/G cg25457927 chr22:38595422 NA -0.4 -7.85 -0.39 5.55e-14 Cutaneous nevi; LUSC cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg08999081 chr20:33150536 PIGU 0.51 10.12 0.48 3.48e-21 Glomerular filtration rate (creatinine); LUSC cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg00071950 chr4:10020882 SLC2A9 -0.53 -8.18 -0.41 5.96e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg24250549 chr1:154909240 PMVK 0.64 10.53 0.5 1.42e-22 Prostate cancer; LUSC cis rs9486719 1.000 rs2472888 chr6:96865501 T/C cg06623918 chr6:96969491 KIAA0776 0.8 9.95 0.48 1.37e-20 Migraine;Coronary artery disease; LUSC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg26597838 chr10:835615 NA 1.22 16.19 0.66 6.1e-44 Eosinophil percentage of granulocytes; LUSC cis rs12620999 1.000 rs10803655 chr2:238075551 C/T cg23555395 chr2:238036564 NA -0.47 -8.34 -0.41 2.03e-15 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg08270630 chr22:50330655 NA -0.42 -6.29 -0.33 1e-9 Schizophrenia; LUSC trans rs2018683 0.707 rs4722877 chr7:28972906 A/G cg19402173 chr7:128379420 CALU -0.47 -7.08 -0.36 8.32e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9549367 0.774 rs9549364 chr13:113903745 T/C cg18105134 chr13:113819100 PROZ -0.68 -9.6 -0.47 1.9e-19 Platelet distribution width; LUSC cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs1153858 1.000 rs2467864 chr15:45641098 C/T cg26924012 chr15:45694286 SPATA5L1 -1.11 -20.23 -0.74 5.6e-60 Homoarginine levels; LUSC cis rs11971779 0.680 rs2355788 chr7:139101897 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg24110177 chr3:50126178 RBM5 -0.55 -9.03 -0.44 1.35e-17 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg17279839 chr7:150038598 RARRES2 -0.53 -7.93 -0.4 3.37e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs9814567 0.929 rs13088413 chr3:134309977 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.85 14.02 0.61 1.89e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1018836 0.631 rs9987164 chr8:91470910 T/G cg16814680 chr8:91681699 NA -0.56 -8.27 -0.41 3.28e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6500395 1.000 rs11643264 chr16:48558462 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.41e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3740713 1.000 rs1848048 chr11:18468996 T/C cg15463284 chr11:18477534 LDHAL6A -0.5 -5.73 -0.3 2.21e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs763121 0.853 rs1569492 chr22:38975511 A/G cg06022373 chr22:39101656 GTPBP1 -0.72 -11.82 -0.54 3.6e-27 Menopause (age at onset); LUSC cis rs2762353 1.000 rs2762353 chr6:25794431 A/G cg03264133 chr6:25882463 NA -0.42 -7.25 -0.37 2.97e-12 Blood metabolite levels; LUSC cis rs7091068 0.671 rs514120 chr10:95404400 G/A cg20715218 chr10:95462985 C10orf4 -0.59 -6.78 -0.35 5.32e-11 Urinary tract infection frequency; LUSC cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.53e-21 Bladder cancer; LUSC cis rs701145 0.556 rs191651 chr3:153973887 T/G cg10247383 chr3:153839028 SGEF -0.48 -5.9 -0.31 8.75e-9 Coronary artery disease; LUSC cis rs8040855 0.599 rs2342123 chr15:85725149 C/G cg04831495 chr15:85060580 GOLGA6L5 -0.41 -6.94 -0.35 2.11e-11 Bulimia nervosa; LUSC cis rs1448094 0.967 rs10779222 chr12:86330775 G/A cg02569458 chr12:86230093 RASSF9 0.42 6.86 0.35 3.31e-11 Major depressive disorder; LUSC cis rs240764 0.631 rs9322174 chr6:101204193 G/C cg09795085 chr6:101329169 ASCC3 -0.44 -6.32 -0.33 8.3e-10 Neuroticism; LUSC cis rs8062405 0.755 rs4788076 chr16:28570005 C/T cg16576597 chr16:28551801 NUPR1 0.32 6.53 0.34 2.39e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs5771242 0.518 rs67881086 chr22:50673439 G/A cg16473166 chr22:50639996 SELO 0.69 9.56 0.46 2.77e-19 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); LUSC trans rs1908814 0.516 rs13281077 chr8:11794814 C/T cg08975724 chr8:8085496 FLJ10661 0.48 6.95 0.36 1.87e-11 Neuroticism; LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.73 0.65 4.3e-42 Platelet count; LUSC cis rs9323205 0.765 rs2999386 chr14:51652628 G/T cg23942311 chr14:51606299 NA 0.32 6.67 0.34 1.06e-10 Cancer; LUSC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.8 -0.35 4.8e-11 Alzheimer's disease (late onset); LUSC cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg18099408 chr3:52552593 STAB1 0.36 5.96 0.31 6.41e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs6076065 0.748 rs6048750 chr20:23334192 T/G cg11657817 chr20:23433608 CST11 0.53 10.68 0.5 4.37e-23 Facial morphology (factor 15, philtrum width); LUSC cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg18681998 chr4:17616180 MED28 0.86 15.49 0.65 3.49e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7617773 0.817 rs9834095 chr3:48327751 G/A cg20734569 chr3:48348370 SPINK8 -0.47 -8.17 -0.41 6.44e-15 Coronary artery disease; LUSC cis rs1524927 1.000 rs12704870 chr7:96331727 A/G cg03808172 chr7:96339361 SHFM1 0.43 6.48 0.33 3.34e-10 Total body bone mineral density; LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.45 7.72 0.39 1.37e-13 Bipolar disorder; LUSC cis rs9303401 0.659 rs34170300 chr17:56789905 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg21361702 chr7:150065534 REPIN1 0.58 8.47 0.42 8.02e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs7707921 0.881 rs112413913 chr5:81359709 A/G cg15871215 chr5:81402204 ATG10 -0.45 -6.48 -0.33 3.3e-10 Breast cancer; LUSC cis rs10426930 0.700 rs10413045 chr19:5024099 G/T cg25246084 chr19:4971487 KDM4B -0.34 -6.2 -0.32 1.65e-9 Monocyte percentage of white cells; LUSC cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg05340658 chr4:99064831 C4orf37 0.65 11.36 0.53 1.66e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4891159 0.756 rs8084155 chr18:74134952 A/G cg24786174 chr18:74118243 ZNF516 -0.92 -19.39 -0.73 1.24e-56 Longevity; LUSC cis rs644799 0.511 rs1016030 chr11:95472693 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.54 7.36 0.37 1.42e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs662064 0.890 rs1632108 chr1:10561923 C/T cg20482658 chr1:10539492 PEX14 0.33 6.79 0.35 5.27e-11 Asthma; LUSC cis rs738322 0.839 rs9607517 chr22:38596100 G/A cg17652424 chr22:38574118 PLA2G6 0.28 5.95 0.31 6.68e-9 Cutaneous nevi; LUSC cis rs738322 0.719 rs34066050 chr22:38612604 G/A cg17652424 chr22:38574118 PLA2G6 0.28 5.81 0.3 1.45e-8 Cutaneous nevi; LUSC cis rs7000551 0.688 rs2948145 chr8:22367792 T/C cg12081754 chr8:22256438 SLC39A14 0.42 6.41 0.33 5.03e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1775715 0.835 rs12266771 chr10:32231380 G/A cg26784012 chr10:32216390 ARHGAP12 0.42 6.93 0.35 2.19e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.76 -0.3 1.87e-8 Depression; LUSC cis rs8062405 0.723 rs113208333 chr16:28606160 G/T cg07382826 chr16:28625726 SULT1A1 0.27 5.87 0.31 1.04e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs826838 0.510 rs10506129 chr12:39224242 A/T cg13010199 chr12:38710504 ALG10B 0.62 9.14 0.45 6.27e-18 Heart rate; LUSC cis rs5769765 0.505 rs4561759 chr22:50256686 C/T cg02269571 chr22:50332266 NA 0.59 7.57 0.38 3.67e-13 Schizophrenia; LUSC cis rs814295 0.736 rs78680773 chr2:27751562 A/C cg27432699 chr2:27873401 GPN1 0.53 5.92 0.31 8.07e-9 Triglyceride levels; LUSC cis rs79149102 0.579 rs7168638 chr15:75280826 T/C cg09165964 chr15:75287851 SCAMP5 -0.92 -8.08 -0.4 1.19e-14 Lung cancer; LUSC cis rs7786808 0.525 rs10253961 chr7:158194858 G/A cg01191920 chr7:158217561 PTPRN2 0.46 9.22 0.45 3.55e-18 Obesity-related traits; LUSC trans rs9380880 0.826 rs9380882 chr6:39547428 A/T cg12580580 chr10:74544059 CCDC109A 0.59 6.68 0.34 9.96e-11 Immune response to smallpox vaccine (IL-6); LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -8.0 -0.4 2.05e-14 Lymphocyte counts; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg00684032 chr4:1343700 KIAA1530 0.34 5.86 0.31 1.13e-8 Obesity-related traits; LUSC cis rs9677476 0.909 rs13428369 chr2:232125632 T/C cg07929768 chr2:232055508 NA 0.31 5.9 0.31 9.1e-9 Food antigen IgG levels; LUSC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg07636037 chr3:49044803 WDR6 0.44 6.35 0.33 7.23e-10 Resting heart rate; LUSC cis rs3008870 0.755 rs4486425 chr1:67460791 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.75 -12.33 -0.56 5.01e-29 Lymphocyte percentage of white cells; LUSC cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs9462027 0.583 rs9462022 chr6:34761684 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.77 -0.3 1.84e-8 Systemic lupus erythematosus; LUSC cis rs2235649 0.833 rs9926962 chr16:1851826 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -6.09 -0.32 3.19e-9 Blood metabolite levels; LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg04597389 chr17:79935740 ASPSCR1 0.45 6.07 0.32 3.54e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg19717773 chr7:2847554 GNA12 -0.32 -5.65 -0.3 3.44e-8 Height; LUSC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg06713675 chr4:122721982 EXOSC9 -0.45 -8.02 -0.4 1.86e-14 Type 2 diabetes; LUSC cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 29.27 0.85 3.41e-94 Chronic sinus infection; LUSC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.74 -12.64 -0.57 3.43e-30 Total body bone mineral density; LUSC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg21862992 chr11:68658383 NA 0.51 8.15 0.41 7.21e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg02569458 chr12:86230093 RASSF9 0.52 8.36 0.42 1.67e-15 Major depressive disorder; LUSC cis rs877282 0.755 rs2790388 chr10:786084 T/C cg17470449 chr10:769945 NA 0.41 6.03 0.31 4.33e-9 Uric acid levels; LUSC cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg00071950 chr4:10020882 SLC2A9 0.58 9.7 0.47 9.23e-20 Bone mineral density; LUSC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.82 -0.35 4.29e-11 Total body bone mineral density; LUSC trans rs62103177 0.810 rs62103178 chr18:77624555 C/G cg14227996 chr4:17616232 MED28 0.8 7.86 0.4 5.18e-14 Opioid sensitivity; LUSC trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg16850897 chr7:100343110 ZAN -0.54 -7.55 -0.38 4.27e-13 Other erythrocyte phenotypes; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg16362232 chr11:430036 ANO9 0.62 8.05 0.4 1.48e-14 Body mass index; LUSC cis rs73206853 0.640 rs3825390 chr12:110976409 A/C cg12870014 chr12:110450643 ANKRD13A 0.74 9.41 0.46 8.49e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs77633900 0.614 rs280033 chr15:77023099 G/A cg21673338 chr15:77095150 SCAPER -0.82 -8.07 -0.4 1.26e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -7.48 -0.38 6.84e-13 Menarche (age at onset); LUSC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.29e-11 Glomerular filtration rate (creatinine); LUSC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg18225595 chr11:63971243 STIP1 0.54 7.18 0.37 4.49e-12 Mean platelet volume; LUSC cis rs9653442 0.545 rs11123810 chr2:100759285 T/C cg07810366 chr2:100720526 AFF3 -0.46 -7.78 -0.39 9.22e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg14019146 chr3:50243930 SLC38A3 0.33 7.23 0.37 3.41e-12 Intelligence (multi-trait analysis); LUSC cis rs6736093 0.966 rs11679801 chr2:112712835 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.87 -0.31 1.02e-8 Coronary artery disease; LUSC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.15 0.58 4.25e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC trans rs885518 0.636 rs10811612 chr9:21774167 C/G cg06483441 chr5:102442571 GIN1 -0.64 -6.38 -0.33 5.79e-10 Lung adenocarcinoma; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11905131 chr22:24372483 LOC391322 -0.49 -8.44 -0.42 1.01e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6696846 0.905 rs12117194 chr1:205040943 C/G cg00857998 chr1:205179979 DSTYK -0.52 -8.32 -0.41 2.2e-15 Red blood cell count; LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs5769707 0.632 rs5770601 chr22:50021903 A/G cg05373962 chr22:49881684 NA -0.41 -8.45 -0.42 8.97e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9467711 0.606 rs12174602 chr6:26372827 C/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9462027 0.628 rs4601124 chr6:34776910 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg04455712 chr21:45112962 RRP1B 0.44 8.28 0.41 3.06e-15 Mean corpuscular volume; LUSC cis rs11971779 0.680 rs9683 chr7:139107739 T/A cg23387468 chr7:139079360 LUC7L2 0.4 6.08 0.32 3.28e-9 Diisocyanate-induced asthma; LUSC cis rs1775715 0.870 rs11008702 chr10:32244818 T/G cg18675610 chr10:32216311 ARHGAP12 0.27 5.76 0.3 1.96e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7769051 0.808 rs1467404 chr6:133090141 A/G cg07930552 chr6:133119739 C6orf192 -0.74 -9.87 -0.48 2.45e-20 Type 2 diabetes nephropathy; LUSC cis rs17376456 0.569 rs7702348 chr5:93065683 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.43 -5.81 -0.3 1.48e-8 Diabetic retinopathy; LUSC cis rs7267979 0.844 rs6107017 chr20:25232300 A/G cg08601574 chr20:25228251 PYGB 0.55 8.83 0.43 6.23e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg03433033 chr1:76189801 ACADM 0.63 7.91 0.4 3.7e-14 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2346177 0.554 rs13002880 chr2:46708129 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.6 -9.54 -0.46 3.15e-19 HDL cholesterol; LUSC cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg13256891 chr4:100009986 ADH5 0.5 6.91 0.35 2.41e-11 Smoking initiation; LUSC cis rs10089 0.953 rs7713860 chr5:127428789 G/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.84 -0.3 1.21e-8 Ileal carcinoids; LUSC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg00033643 chr7:134001901 SLC35B4 0.47 7.39 0.37 1.19e-12 Mean platelet volume; LUSC cis rs950169 0.922 rs8037078 chr15:84818871 A/G cg17173187 chr15:85201210 NMB -0.37 -6.85 -0.35 3.65e-11 Schizophrenia; LUSC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg08645402 chr16:4508243 NA 0.48 7.37 0.37 1.36e-12 Schizophrenia; LUSC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg09877947 chr5:131593287 PDLIM4 0.42 6.96 0.36 1.76e-11 Blood metabolite levels; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg22907277 chr7:1156413 C7orf50 0.57 8.91 0.44 3.25e-17 Longevity;Endometriosis; LUSC cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg05283184 chr6:79620031 NA -0.56 -11.8 -0.54 4.14e-27 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.867 rs28729853 chr15:43673680 A/C cg02155558 chr15:43621948 ADAL;LCMT2 1.06 12.91 0.58 3.43e-31 Lung cancer in ever smokers; LUSC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.31 0.45 1.75e-18 Total body bone mineral density; LUSC cis rs11864453 0.713 rs8051882 chr16:72142072 A/G cg01557791 chr16:72042693 DHODH 0.51 7.42 0.38 9.69e-13 Fibrinogen levels; LUSC cis rs6121246 0.909 rs6089070 chr20:30377773 A/G cg21427119 chr20:30132790 HM13 0.39 5.83 0.3 1.34e-8 Mean corpuscular hemoglobin; LUSC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.74 -0.35 6.77e-11 Alzheimer's disease (late onset); LUSC cis rs7833986 0.501 rs72653941 chr8:56942247 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.72 11.84 0.54 2.97e-27 Height; LUSC cis rs354225 0.584 rs10188545 chr2:54831875 A/G cg01766943 chr2:54829624 SPTBN1 0.49 7.66 0.39 1.98e-13 Schizophrenia; LUSC cis rs10832963 1.000 rs7943121 chr11:18656062 G/C cg20219074 chr11:18656078 SPTY2D1 0.73 10.97 0.51 3.96e-24 Breast cancer; LUSC cis rs59698941 0.527 rs1910075 chr5:132180089 A/T cg14825688 chr5:132208181 LEAP2 -0.44 -6.49 -0.33 3.17e-10 Apolipoprotein A-IV levels; LUSC cis rs72960926 0.744 rs72957986 chr6:74969096 A/C cg03266952 chr6:74778945 NA -0.8 -6.94 -0.36 2e-11 Metabolite levels (MHPG); LUSC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg03351412 chr1:154909251 PMVK 0.46 7.08 0.36 8.74e-12 Prostate cancer; LUSC cis rs897984 0.806 rs8052245 chr16:30916430 C/G cg02466173 chr16:30829666 NA 0.56 11.47 0.53 6.6900000000000006e-26 Dementia with Lewy bodies; LUSC cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg22455342 chr2:225449267 CUL3 -0.89 -11.89 -0.55 2.02e-27 IgE levels in asthmatics (D.p. specific); LUSC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg15534755 chr11:117069859 TAGLN 0.35 6.14 0.32 2.33e-9 Blood protein levels; LUSC trans rs35110281 0.777 rs7276215 chr21:44990697 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.62 10.84 0.51 1.19e-23 Mean corpuscular volume; LUSC cis rs5769765 0.773 rs138861 chr22:50202276 A/G cg02269571 chr22:50332266 NA -0.53 -7.87 -0.4 4.86e-14 Schizophrenia; LUSC cis rs7843479 0.601 rs9969551 chr8:21860007 T/C cg17168535 chr8:21777572 XPO7 0.8 14.3 0.62 1.6e-36 Mean corpuscular volume; LUSC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg26513180 chr16:89883248 FANCA 0.91 17.79 0.7 2.93e-50 Vitiligo; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg26304593 chr6:42947056 PEX6 -0.51 -7.91 -0.4 3.84e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs17095355 1.000 rs921348 chr10:111707498 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.54 -0.38 4.61e-13 Biliary atresia; LUSC cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs12940923 1.000 rs2877875 chr17:56375765 C/T cg19466818 chr17:56409534 MIR142 -0.37 -6.42 -0.33 4.77e-10 Circulating myeloperoxidase levels (plasma); LUSC cis rs4499344 0.555 rs7250741 chr19:33033231 T/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.77 -10.31 -0.49 8.03e-22 Mean platelet volume; LUSC cis rs10028773 0.515 rs9994488 chr4:120587781 C/T cg24375607 chr4:120327624 NA 0.64 9.51 0.46 3.89e-19 Educational attainment; LUSC trans rs7937682 0.889 rs578022 chr11:111490552 G/T cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg14019146 chr3:50243930 SLC38A3 -0.33 -7.18 -0.37 4.54e-12 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.569 rs1872746 chr12:33985843 T/C cg13010199 chr12:38710504 ALG10B 0.45 7.19 0.37 4.24e-12 Morning vs. evening chronotype; LUSC cis rs4363385 0.720 rs1611754 chr1:152956415 A/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.43 -0.38 9.27e-13 Inflammatory skin disease; LUSC cis rs1577917 0.958 rs12209668 chr6:86566517 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC trans rs11098499 0.863 rs59732491 chr4:120489588 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.65 0.34 1.22e-10 Corneal astigmatism; LUSC cis rs1983891 0.865 rs10947980 chr6:41525739 A/G cg20194872 chr6:41519635 FOXP4 0.35 5.99 0.31 5.35e-9 Prostate cancer; LUSC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg19592336 chr6:28129416 ZNF389 0.48 6.3 0.33 9.46e-10 Depression; LUSC cis rs3736594 0.918 rs12471347 chr2:27981655 G/C cg27432699 chr2:27873401 GPN1 0.64 8.82 0.43 6.5e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs950027 0.620 rs872192 chr15:45614502 A/G cg21132104 chr15:45694354 SPATA5L1 0.4 5.68 0.3 2.87e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg13628971 chr7:2884303 GNA12 0.48 6.72 0.35 7.74e-11 Height; LUSC cis rs7523050 0.643 rs17621851 chr1:109400835 C/T cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs1062746 0.834 rs9308347 chr16:87371752 C/T cg02258303 chr16:87377426 FBXO31 -0.6 -10.07 -0.48 5.18e-21 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs1790761 0.667 rs658768 chr11:67337808 G/A cg08355456 chr11:67383691 NA 0.38 7.01 0.36 1.35e-11 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg11062466 chr8:58055876 NA 0.66 8.97 0.44 2.22e-17 Developmental language disorder (linguistic errors); LUSC trans rs12210905 1.000 rs12205628 chr6:27225959 C/A cg11837749 chr1:55047332 ACOT11 0.58 5.98 0.31 5.64e-9 Hip circumference adjusted for BMI; LUSC cis rs7267979 0.932 rs372678 chr20:25465248 G/A cg08601574 chr20:25228251 PYGB 0.42 6.35 0.33 7.01e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6964587 0.967 rs28399886 chr7:91638451 A/G cg17063962 chr7:91808500 NA 0.58 9.08 0.44 9.76e-18 Breast cancer; LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg20887711 chr4:1340912 KIAA1530 0.69 10.72 0.51 2.99e-23 Longevity; LUSC cis rs16917546 0.967 rs10995256 chr10:64402434 G/T cg03961010 chr10:64397487 ZNF365 -0.41 -6.5 -0.33 2.98e-10 Basal cell carcinoma; LUSC cis rs34779708 0.966 rs4934732 chr10:35431684 T/C cg04310649 chr10:35416472 CREM -0.42 -6.61 -0.34 1.52e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13315871 1.000 rs11715445 chr3:58343888 T/C cg20936604 chr3:58311152 NA -0.72 -7.09 -0.36 8.14e-12 Cholesterol, total; LUSC trans rs4714291 0.894 rs2253393 chr6:39953821 G/A cg02267698 chr19:7991119 CTXN1 0.5 6.92 0.35 2.37e-11 Strep throat; LUSC cis rs6714710 0.603 rs956039 chr2:98416848 C/A cg26665480 chr2:98280029 ACTR1B 0.64 9.26 0.45 2.47e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9311676 0.632 rs11925533 chr3:58429908 G/A cg13750441 chr3:58318267 PXK 0.35 6.84 0.35 3.88e-11 Systemic lupus erythematosus; LUSC cis rs9287719 0.967 rs6735074 chr2:10734766 G/T cg00105475 chr2:10696890 NA -0.36 -6.09 -0.32 3.15e-9 Prostate cancer; LUSC cis rs17818399 0.533 rs4384837 chr2:46789514 A/G cg02822958 chr2:46747628 ATP6V1E2 0.36 5.78 0.3 1.68e-8 Height; LUSC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg14949292 chr17:78079608 GAA -0.31 -5.89 -0.31 9.42e-9 Yeast infection; LUSC cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg01884057 chr2:25150051 NA 0.48 11.39 0.53 1.31e-25 Body mass index; LUSC cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg12292205 chr6:26970375 C6orf41 -0.64 -9.24 -0.45 2.98e-18 Intelligence (multi-trait analysis); LUSC trans rs9650657 0.547 rs11250099 chr8:10818657 C/T cg08975724 chr8:8085496 FLJ10661 0.42 6.04 0.31 4.02e-9 Neuroticism; LUSC cis rs7638995 0.878 rs17005384 chr3:69181552 A/G cg26574240 chr3:69171822 LMOD3 0.6 8.4 0.42 1.27e-15 Alzheimer's disease (late onset); LUSC cis rs11155671 0.530 rs3823021 chr6:150210999 G/C cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC cis rs11677416 1.000 rs6542090 chr2:113524795 T/C cg27083787 chr2:113543245 IL1A 0.44 6.78 0.35 5.4e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC trans rs6952808 1.000 rs4721121 chr7:1892565 A/G cg24247370 chr13:99142703 STK24 -0.32 -5.95 -0.31 6.69e-9 Bipolar disorder and schizophrenia; LUSC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg20276088 chr3:133502917 NA -0.42 -6.17 -0.32 2.02e-9 Iron status biomarkers; LUSC cis rs208520 0.560 rs2351880 chr6:66863707 G/A cg07460842 chr6:66804631 NA -1.13 -17.56 -0.69 2.24e-49 Exhaled nitric oxide output; LUSC cis rs17095355 1.000 rs6584962 chr10:111689904 G/A cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.12 -0.36 6.59e-12 Biliary atresia; LUSC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs61990749 0.597 rs1008988 chr14:78260795 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.32 0.33 8.57e-10 Fibroblast growth factor basic levels; LUSC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg09877947 chr5:131593287 PDLIM4 0.48 7.9 0.4 4.12e-14 Breast cancer; LUSC cis rs56104184 0.779 rs4802513 chr19:49357656 T/A cg15549821 chr19:49342101 PLEKHA4 -0.92 -10.72 -0.51 2.98e-23 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs9788682 0.642 rs2568483 chr15:78752343 A/G cg18825076 chr15:78729989 IREB2 0.44 6.13 0.32 2.54e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1775715 0.651 rs2808033 chr10:32194127 A/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.67 0.34 1.07e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2439831 0.867 rs2264876 chr15:43757419 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs911555 0.655 rs10149470 chr14:104017953 A/G cg24130564 chr14:104152367 KLC1 -0.46 -7.06 -0.36 9.72e-12 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg20283391 chr11:68216788 NA -0.51 -7.39 -0.38 1.16e-12 Total body bone mineral density; LUSC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg02423579 chr7:2872169 GNA12 0.46 6.78 0.35 5.35e-11 Height; LUSC cis rs2637266 0.935 rs7900900 chr10:78367383 A/T cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.64e-12 Pulmonary function; LUSC cis rs2479724 0.591 rs4526183 chr6:41829267 T/C cg17623882 chr6:41773611 USP49 -0.52 -6.79 -0.35 5.25e-11 Menarche (age at onset); LUSC cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg11984989 chr7:158649758 WDR60 1.06 20.78 0.75 3.74e-62 Height; LUSC trans rs724744 0.680 rs1205943 chr6:22356914 A/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7954584 0.567 rs11612028 chr12:122387872 C/G cg10207240 chr12:122356781 WDR66 0.47 6.77 0.35 5.88e-11 Mean corpuscular volume; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.24 0.41 3.92e-15 Prudent dietary pattern; LUSC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg18538332 chr22:24372958 LOC391322 -0.43 -7.72 -0.39 1.36e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.47 -0.38 6.84e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg13206674 chr6:150067644 NUP43 0.62 10.12 0.48 3.53e-21 Lung cancer; LUSC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs28647808 0.881 rs7029386 chr9:136263736 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.41 0.46 8.16e-19 Prudent dietary pattern; LUSC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg26116260 chr4:7069785 GRPEL1 -1.12 -12.87 -0.58 4.68e-31 Monocyte percentage of white cells; LUSC cis rs1728785 0.681 rs4783647 chr16:68558048 G/A cg02972257 chr16:68554789 NA 0.55 6.78 0.35 5.39e-11 Ulcerative colitis; LUSC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg13175981 chr1:150552382 MCL1 0.44 5.75 0.3 2.04e-8 Urate levels; LUSC cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg15704280 chr7:45808275 SEPT13 -0.84 -13.97 -0.61 3.09e-35 Height; LUSC cis rs4499344 0.521 rs259222 chr19:33136895 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.93 13.7 0.6 3.28e-34 Mean platelet volume; LUSC cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg23711669 chr6:146136114 FBXO30 0.89 16.79 0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg06481639 chr22:41940642 POLR3H 0.48 5.87 0.31 1.05e-8 Vitiligo; LUSC cis rs11758351 1.000 rs2143347 chr6:26198494 C/T cg01420254 chr6:26195488 NA 0.71 7.39 0.37 1.23e-12 Gout;Renal underexcretion gout; LUSC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg21361702 chr7:150065534 REPIN1 0.51 6.5 0.33 2.97e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg13683864 chr3:40499215 RPL14 -1.02 -17.47 -0.69 5.06e-49 Renal cell carcinoma; LUSC cis rs425277 0.917 rs78395918 chr1:2045876 G/A cg24578937 chr1:2090814 PRKCZ 0.57 12.48 0.56 1.28e-29 Height; LUSC cis rs2219968 1.000 rs13281300 chr8:78966585 A/G cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.646 rs13103430 chr4:17567355 A/C cg16339924 chr4:17578868 LAP3 -0.56 -7.49 -0.38 6.12e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -8.9 -0.44 3.51e-17 Bipolar disorder and schizophrenia; LUSC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg18876405 chr7:65276391 NA -0.68 -12.09 -0.55 3.72e-28 Aortic root size; LUSC cis rs1577917 0.876 rs12201992 chr6:86618219 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC cis rs4919694 1.000 rs12245779 chr10:104645944 C/A cg04362960 chr10:104952993 NT5C2 1.17 13.39 0.59 5.02e-33 Arsenic metabolism; LUSC cis rs6500602 0.727 rs10451135 chr16:4580214 T/C cg08645402 chr16:4508243 NA 0.51 8.69 0.43 1.65e-16 Schizophrenia; LUSC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg21132104 chr15:45694354 SPATA5L1 -0.58 -8.14 -0.41 7.73e-15 Homoarginine levels; LUSC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.1 15.88 0.66 1.04e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs73198271 0.562 rs964773 chr8:8651314 T/C cg01851573 chr8:8652454 MFHAS1 0.6 8.29 0.41 2.81e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg04414720 chr1:150670196 GOLPH3L 0.45 6.53 0.34 2.44e-10 Tonsillectomy; LUSC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg17747265 chr1:1875780 NA -0.58 -12.02 -0.55 6.84e-28 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14014471 chr1:178694459 RALGPS2 0.4 6.13 0.32 2.44e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11025559 0.812 rs10766678 chr11:20507180 A/G cg19653624 chr11:20408972 PRMT3 -0.7 -8.88 -0.44 4.28e-17 Pursuit maintenance gain; LUSC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.8 -0.35 4.8e-11 Alzheimer's disease (late onset); LUSC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg27535305 chr1:53392650 SCP2 -0.4 -7.69 -0.39 1.62e-13 Monocyte count; LUSC cis rs72781680 0.898 rs72786279 chr2:24063266 C/T cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs67981189 0.593 rs10140917 chr14:71491820 T/C cg15816911 chr14:71606274 NA 0.33 5.86 0.31 1.1e-8 Schizophrenia; LUSC cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.5 -0.46 4.07e-19 Schizophrenia; LUSC trans rs9329221 0.527 rs7833781 chr8:10333477 A/G cg06636001 chr8:8085503 FLJ10661 0.45 6.28 0.32 1.06e-9 Neuroticism; LUSC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg03709012 chr19:19516395 GATAD2A -0.82 -13.01 -0.58 1.39e-31 Tonsillectomy; LUSC cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg18132916 chr6:79620363 NA -0.39 -6.01 -0.31 4.88e-9 Intelligence (multi-trait analysis); LUSC cis rs7178572 0.568 rs7166927 chr15:77673459 A/G cg22256960 chr15:77711686 NA 0.5 7.92 0.4 3.58e-14 Type 2 diabetes; LUSC cis rs6845621 0.901 rs1377152 chr4:18922896 A/G cg12196642 chr4:18937545 NA -0.35 -6.62 -0.34 1.46e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9916302 0.571 rs28799952 chr17:37533056 C/T cg07936489 chr17:37558343 FBXL20 0.8 9.85 0.47 2.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs2236521 0.659 rs72487383 chr20:60889313 A/C cg12382846 chr20:60892121 LAMA5 0.32 5.93 0.31 7.59e-9 Pelvic organ prolapse; LUSC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg15485101 chr11:133734466 NA 0.43 7.67 0.39 1.93e-13 Childhood ear infection; LUSC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg13902645 chr11:5959945 NA -0.6 -8.44 -0.42 9.71e-16 DNA methylation (variation); LUSC cis rs765787 0.530 rs4775836 chr15:45537664 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg11941060 chr3:133502564 NA -0.62 -10.15 -0.49 2.78e-21 Iron status biomarkers; LUSC cis rs2688608 0.869 rs2633308 chr10:75653904 A/T cg17411546 chr10:75410026 SYNPO2L -0.44 -6.68 -0.34 1.03e-10 Inflammatory bowel disease; LUSC cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg01849466 chr14:104193079 ZFYVE21 0.51 8.39 0.42 1.42e-15 Schizophrenia; LUSC cis rs10203711 0.933 rs1810139 chr2:239568154 A/C cg14580085 chr2:239553406 NA 0.4 6.73 0.35 7.48e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs921968 0.529 rs6729341 chr2:219611434 T/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.09 -0.48 4.66e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs7180079 1.000 rs6494475 chr15:64634884 C/A cg08069370 chr15:64387884 SNX1 0.55 5.99 0.31 5.37e-9 Monocyte count; LUSC cis rs7914558 0.966 rs3977751 chr10:104920232 A/G cg05855489 chr10:104503620 C10orf26 0.58 9.69 0.47 1.02e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01555307 chr17:61044018 NA -0.42 -6.29 -0.33 9.71e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg03351412 chr1:154909251 PMVK 0.53 8.35 0.42 1.9e-15 Prostate cancer; LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg27535305 chr1:53392650 SCP2 0.46 8.95 0.44 2.46e-17 Monocyte count; LUSC cis rs7180079 0.620 rs2414856 chr15:65072461 A/G cg08069370 chr15:64387884 SNX1 0.55 5.87 0.31 1.05e-8 Monocyte count; LUSC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg09796270 chr17:17721594 SREBF1 -0.42 -7.3 -0.37 2.11e-12 Total body bone mineral density; LUSC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg04398451 chr17:18023971 MYO15A 0.57 9.56 0.46 2.63e-19 Total body bone mineral density; LUSC cis rs7605827 0.780 rs34739027 chr2:15532146 C/A cg19274914 chr2:15703543 NA 0.46 9.06 0.44 1.08e-17 Educational attainment (years of education); LUSC cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg24642439 chr20:33292090 TP53INP2 0.47 7.16 0.36 5.26e-12 Glomerular filtration rate (creatinine); LUSC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg22029157 chr1:209979665 IRF6 0.72 9.02 0.44 1.48e-17 Cleft lip with or without cleft palate; LUSC cis rs7647973 0.593 rs1799844 chr3:49847642 G/A cg13072238 chr3:49761600 GMPPB 0.69 8.78 0.43 8.71e-17 Menarche (age at onset); LUSC cis rs4862307 0.754 rs6846007 chr4:184991604 A/G cg06737308 chr4:185021514 ENPP6 -0.42 -6.56 -0.34 2.05e-10 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.5 -7.1 -0.36 7.66e-12 Renal function-related traits (BUN); LUSC cis rs9800506 1.000 rs9800506 chr6:35517390 G/T cg03566752 chr6:35512600 NA 0.24 5.7 0.3 2.57e-8 Neutrophil percentage of granulocytes; LUSC cis rs6494488 0.500 rs72742993 chr15:65006023 G/C cg08069370 chr15:64387884 SNX1 -0.66 -5.77 -0.3 1.76e-8 Coronary artery disease; LUSC trans rs11696501 0.739 rs6073821 chr20:44251791 A/G cg03272292 chr12:48577362 C12orf68 0.49 5.99 0.31 5.29e-9 Brain structure; LUSC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg03732007 chr1:2071316 PRKCZ 0.56 10.11 0.48 3.8e-21 Height; LUSC trans rs208520 0.690 rs1580430 chr6:66715162 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 16.88 0.68 1.17e-46 Exhaled nitric oxide output; LUSC trans rs61931739 0.534 rs11053021 chr12:34111157 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.38 0.42 1.5e-15 Morning vs. evening chronotype; LUSC cis rs9715521 0.775 rs67846233 chr4:59848576 G/A cg11281224 chr4:60001000 NA -0.46 -6.47 -0.33 3.55e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs921968 0.565 rs6745700 chr2:219639862 T/C cg02176678 chr2:219576539 TTLL4 -0.55 -9.78 -0.47 4.92e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.04 -0.36 1.09e-11 Asthma; LUSC cis rs1371867 0.846 rs1660351 chr8:101275034 C/T cg06636551 chr8:101224915 SPAG1 -0.43 -7.99 -0.4 2.2e-14 Atrioventricular conduction; LUSC cis rs713477 1.000 rs7142204 chr14:55908436 G/T cg13175173 chr14:55914753 NA 0.34 7.1 0.36 7.45e-12 Pediatric bone mineral content (femoral neck); LUSC cis rs10754283 0.934 rs10493829 chr1:90117833 T/C cg21401794 chr1:90099060 LRRC8C 0.61 8.79 0.43 7.99e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg00933542 chr6:150070202 PCMT1 0.3 6.07 0.32 3.4e-9 Lung cancer; LUSC cis rs7208859 0.623 rs73269974 chr17:29112384 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg24503407 chr1:205819492 PM20D1 -0.42 -5.71 -0.3 2.56e-8 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs11098499 0.774 rs73842616 chr4:120290683 G/A cg24375607 chr4:120327624 NA 0.69 10.58 0.5 9.19e-23 Corneal astigmatism; LUSC cis rs853679 0.556 rs34706883 chr6:27805255 A/C cg26958806 chr6:27640298 NA 0.81 6.28 0.32 1.05e-9 Depression; LUSC cis rs9361491 0.657 rs9448537 chr6:79437747 G/A cg05283184 chr6:79620031 NA -0.34 -6.2 -0.32 1.66e-9 Intelligence (multi-trait analysis); LUSC cis rs3125734 0.633 rs6479804 chr10:64048327 T/C cg09941381 chr10:64027924 RTKN2 -0.39 -7.06 -0.36 9.64e-12 Rheumatoid arthritis; LUSC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg18479299 chr3:125709523 NA -0.55 -6.89 -0.35 2.84e-11 Blood pressure (smoking interaction); LUSC cis rs4964805 0.586 rs934846 chr12:104185297 C/T cg02344784 chr12:104178138 NT5DC3 0.45 8.7 0.43 1.52e-16 Attention deficit hyperactivity disorder; LUSC cis rs2115630 0.754 rs12595321 chr15:85331269 G/A cg09876464 chr15:85330779 ZNF592 0.35 6.33 0.33 7.7e-10 P wave terminal force; LUSC cis rs4704187 0.663 rs965735 chr5:74459220 A/G cg03227963 chr5:74354835 NA 0.31 6.83 0.35 4.09e-11 Response to amphetamines; LUSC cis rs9733 0.744 rs2039590 chr1:150813315 G/A cg04414720 chr1:150670196 GOLPH3L -0.45 -7.02 -0.36 1.22e-11 Tonsillectomy; LUSC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs2109514 0.840 rs2402080 chr7:116135016 G/C cg12739419 chr7:116140593 CAV2 -0.28 -6.08 -0.32 3.32e-9 Prevalent atrial fibrillation; LUSC cis rs9818941 0.956 rs4317052 chr3:157721994 C/T cg08654915 chr3:157813417 NA 0.23 6.09 0.32 3.1e-9 Height; LUSC cis rs9287719 0.774 rs4997811 chr2:10755538 T/C cg03983476 chr2:10830698 NOL10 -0.38 -5.77 -0.3 1.83e-8 Prostate cancer; LUSC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg13393036 chr8:95962371 TP53INP1 0.44 8.6 0.43 3.05e-16 Type 2 diabetes; LUSC cis rs208520 0.802 rs4710315 chr6:66887594 A/G cg07460842 chr6:66804631 NA -1.06 -15.7 -0.65 5.45e-42 Exhaled nitric oxide output; LUSC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg23719950 chr11:63933701 MACROD1 -0.61 -7.94 -0.4 3.13e-14 Mean platelet volume; LUSC cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg11584989 chr19:19387371 SF4 0.59 7.07 0.36 8.9e-12 Bipolar disorder; LUSC cis rs597583 0.664 rs3819210 chr11:117389517 A/G cg27161313 chr11:117392002 DSCAML1 -0.49 -8.23 -0.41 4.13e-15 Putamen volume; LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg04518342 chr5:131593106 PDLIM4 0.47 8.62 0.43 2.64e-16 Blood metabolite levels; LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg27094323 chr7:1216898 NA -0.38 -6.6 -0.34 1.57e-10 Longevity;Endometriosis; LUSC cis rs2228479 0.681 rs10153196 chr16:89967397 A/C cg00800038 chr16:89945340 TCF25 -0.65 -6.78 -0.35 5.47e-11 Skin colour saturation; LUSC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg12564285 chr5:131593104 PDLIM4 0.33 5.84 0.3 1.25e-8 Breast cancer;Mosquito bite size; LUSC cis rs9467773 0.587 rs9467722 chr6:26352566 T/C cg09904177 chr6:26538194 HMGN4 -0.52 -8.27 -0.41 3.12e-15 Intelligence (multi-trait analysis); LUSC cis rs7605827 0.930 rs4668923 chr2:15681227 G/A cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg17633681 chr16:88106987 BANP 0.52 9.88 0.48 2.27e-20 Menopause (age at onset); LUSC trans rs853679 0.517 rs9380056 chr6:28104476 C/T cg06606381 chr12:133084897 FBRSL1 -0.45 -5.97 -0.31 6.07e-9 Depression; LUSC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg00149659 chr3:10157352 C3orf10 0.64 9.07 0.44 1.04e-17 Alzheimer's disease; LUSC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg04398451 chr17:18023971 MYO15A -0.67 -11.53 -0.53 4.16e-26 Total body bone mineral density; LUSC cis rs7584330 0.826 rs7604315 chr2:238381729 C/G cg16989719 chr2:238392110 NA -0.39 -6.34 -0.33 7.63e-10 Prostate cancer; LUSC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg13206674 chr6:150067644 NUP43 0.51 7.72 0.39 1.35e-13 Lung cancer; LUSC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC cis rs61931739 0.500 rs7137392 chr12:34447074 T/C cg06521331 chr12:34319734 NA -0.41 -6.74 -0.35 6.92e-11 Morning vs. evening chronotype; LUSC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.4 -6.71 -0.34 8.4e-11 Hip circumference adjusted for BMI; LUSC cis rs9467773 0.967 rs6932865 chr6:26540166 C/A cg11502198 chr6:26597334 ABT1 0.59 9.37 0.46 1.15e-18 Intelligence (multi-trait analysis); LUSC trans rs11039798 0.623 rs588700 chr11:48449889 T/C cg03929089 chr4:120376271 NA -0.58 -6.28 -0.32 1.04e-9 Axial length; LUSC cis rs11971779 0.553 rs36002669 chr7:139113161 T/A cg07862535 chr7:139043722 LUC7L2 0.56 6.98 0.36 1.61e-11 Diisocyanate-induced asthma; LUSC cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg23649088 chr2:200775458 C2orf69 0.59 7.35 0.37 1.56e-12 Schizophrenia; LUSC cis rs9902453 0.791 rs2628166 chr17:28113123 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -9.64 -0.47 1.45e-19 Coffee consumption (cups per day); LUSC cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg18099408 chr3:52552593 STAB1 -0.43 -7.65 -0.39 2.2e-13 Bipolar disorder; LUSC trans rs9944715 0.954 rs8093407 chr18:43849464 A/G cg01718231 chr17:29326311 RNF135 -0.53 -7.68 -0.39 1.75e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs62400317 0.859 rs114017772 chr6:45113862 T/C cg20913747 chr6:44695427 NA -0.46 -7.39 -0.37 1.21e-12 Total body bone mineral density; LUSC cis rs10751667 0.961 rs7482484 chr11:927020 C/T cg01483505 chr11:975446 AP2A2 0.41 5.66 0.3 3.29e-8 Alzheimer's disease (late onset); LUSC cis rs1559088 0.847 rs10423531 chr19:33600140 T/C cg03563238 chr19:33554763 RHPN2 -0.4 -6.43 -0.33 4.3e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9325144 0.560 rs61929893 chr12:38653366 G/A cg26384229 chr12:38710491 ALG10B -0.66 -10.28 -0.49 1.02e-21 Morning vs. evening chronotype; LUSC cis rs6906287 0.559 rs7751467 chr6:118893861 T/A cg21191810 chr6:118973309 C6orf204 0.32 5.92 0.31 8.18e-9 Electrocardiographic conduction measures; LUSC cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg24397884 chr7:158709396 WDR60 -0.77 -12.22 -0.56 1.18e-28 Height; LUSC cis rs6750795 0.502 rs11685196 chr2:232381298 A/G cg19187155 chr2:232395269 NMUR1 0.75 11.94 0.55 1.36e-27 Height; LUSC cis rs7072216 0.922 rs942814 chr10:100151305 A/G cg26618903 chr10:100175079 PYROXD2 -0.3 -5.95 -0.31 6.89e-9 Metabolite levels; LUSC cis rs6543140 0.929 rs6742530 chr2:103082280 G/A cg09003973 chr2:102972529 NA 0.54 6.84 0.35 3.74e-11 Blood protein levels; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg16606324 chr3:10149918 C3orf24 -0.56 -8.63 -0.43 2.53e-16 Alzheimer's disease; LUSC cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg00631329 chr6:26305371 NA -0.48 -9.35 -0.46 1.27e-18 Educational attainment; LUSC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg27068330 chr11:65405492 SIPA1 -0.47 -6.08 -0.32 3.2e-9 Breast cancer; LUSC cis rs9463078 0.526 rs9472337 chr6:44711576 C/A cg25276700 chr6:44698697 NA 0.3 6.26 0.32 1.19e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg06808227 chr14:105710500 BRF1 -0.65 -9.82 -0.47 3.77e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs34734847 1.000 rs35360964 chr12:121156290 T/C cg27246729 chr12:121163418 ACADS 0.47 7.51 0.38 5.56e-13 Mean corpuscular volume; LUSC cis rs10028773 0.600 rs4001390 chr4:120265783 G/C cg24375607 chr4:120327624 NA 0.69 10.92 0.51 6.06e-24 Educational attainment; LUSC cis rs4654899 0.965 rs6692244 chr1:21396886 C/A cg01072550 chr1:21505969 NA -0.53 -8.06 -0.4 1.33e-14 Superior frontal gyrus grey matter volume; LUSC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg08499158 chr17:42289980 UBTF 0.56 8.98 0.44 2.02e-17 Total body bone mineral density; LUSC cis rs3857536 0.813 rs2093253 chr6:66937702 A/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg20295408 chr7:1910781 MAD1L1 -0.48 -6.8 -0.35 4.88e-11 Bipolar disorder and schizophrenia; LUSC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.65 -11.43 -0.53 9.54e-26 Multiple sclerosis; LUSC trans rs7170930 0.618 rs2899716 chr15:66538636 G/A cg06396762 chr16:3202609 NA -0.72 -5.97 -0.31 5.91e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.03 0.85 2.44e-93 Chronic sinus infection; LUSC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg15428835 chr7:75027521 TRIM73;TRIM74 -0.4 -8.0 -0.4 2.09e-14 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg26408565 chr15:76604113 ETFA -0.5 -7.97 -0.4 2.49e-14 Blood metabolite levels; LUSC cis rs2522056 1.000 rs1003533 chr5:131755651 C/T cg24060327 chr5:131705240 SLC22A5 0.48 6.72 0.35 7.78e-11 Lymphocyte counts;Fibrinogen; LUSC trans rs7726839 0.540 rs72703092 chr5:599269 G/A cg25482853 chr8:67687455 SGK3 1.12 15.85 0.66 1.36e-42 Obesity-related traits; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg00149659 chr3:10157352 C3orf10 1.01 14.4 0.62 6.83e-37 Alzheimer's disease; LUSC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg22782873 chr19:19639568 YJEFN3 -0.49 -6.12 -0.32 2.56e-9 Bipolar disorder; LUSC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6690583 1.000 rs2304641 chr1:85513398 C/T cg11262906 chr1:85462892 MCOLN2 0.72 7.9 0.4 4.12e-14 Serum sulfate level; LUSC cis rs17685 0.740 rs2286821 chr7:75611355 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.43 6.78 0.35 5.3e-11 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9534288 0.619 rs9526143 chr13:46675991 C/T cg15192986 chr13:46630673 CPB2 -0.75 -10.77 -0.51 2.06e-23 Blood protein levels; LUSC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg00310523 chr12:86230176 RASSF9 0.51 9.56 0.46 2.65e-19 Major depressive disorder; LUSC cis rs733592 0.524 rs10875744 chr12:48498440 G/C cg24011408 chr12:48396354 COL2A1 0.53 8.72 0.43 1.32e-16 Plateletcrit; LUSC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg08219700 chr8:58056026 NA 0.56 6.75 0.35 6.65e-11 Developmental language disorder (linguistic errors); LUSC cis rs4853525 0.923 rs4853523 chr2:191732779 A/G cg11845111 chr2:191398756 TMEM194B -0.41 -6.05 -0.31 3.93e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC trans rs3919583 0.579 rs3909481 chr5:86944417 A/G cg01120514 chr4:25314414 ZCCHC4 0.59 6.62 0.34 1.41e-10 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.11 0.48 3.78e-21 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07004357 chr22:18893614 DGCR6 0.45 6.56 0.34 2.04e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2692947 0.631 rs2312954 chr2:96772447 C/T cg23100626 chr2:96804247 ASTL -0.3 -7.05 -0.36 1.03e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4478858 0.735 rs6679393 chr1:31770944 T/C cg00250761 chr1:31883323 NA -0.33 -7.97 -0.4 2.59e-14 Alcohol dependence; LUSC cis rs394563 0.559 rs13219868 chr6:149686518 T/G cg07828024 chr6:149772892 ZC3H12D 0.34 7.24 0.37 3.14e-12 Dupuytren's disease; LUSC cis rs9457247 1.000 rs421214 chr6:167396629 A/G cg07741184 chr6:167504864 NA 0.36 6.5 0.34 2.86e-10 Crohn's disease; LUSC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg10523679 chr1:76189770 ACADM 0.86 11.41 0.53 1.11e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg07636037 chr3:49044803 WDR6 0.44 6.36 0.33 6.5e-10 Resting heart rate; LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.94 0.31 7.17e-9 Menopause (age at onset); LUSC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC trans rs6502050 0.799 rs4789674 chr17:80123200 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.71e-10 Life satisfaction; LUSC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg19717773 chr7:2847554 GNA12 -0.34 -5.82 -0.3 1.35e-8 Height; LUSC cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg14500267 chr11:67383377 NA 0.32 5.72 0.3 2.39e-8 Mean corpuscular volume; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg14159672 chr1:205819179 PM20D1 0.54 8.74 0.43 1.17e-16 Menarche (age at onset); LUSC cis rs826838 0.804 rs6580755 chr12:39159190 C/T cg13010199 chr12:38710504 ALG10B 0.7 11.84 0.54 2.97e-27 Heart rate; LUSC cis rs2357013 0.752 rs35254490 chr2:53152835 G/A cg07782112 chr2:53107842 NA -0.41 -6.37 -0.33 6.09e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs597539 0.552 rs10792006 chr11:68722306 T/C cg06112835 chr11:68658793 MRPL21 -0.37 -6.15 -0.32 2.22e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg16339924 chr4:17578868 LAP3 0.5 7.35 0.37 1.54e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17621444 0.505 rs11199146 chr10:121777960 T/A cg02041677 chr10:121771263 NA -0.35 -6.42 -0.33 4.66e-10 IgG glycosylation; LUSC cis rs4595586 0.545 rs12816546 chr12:39398913 C/T cg26384229 chr12:38710491 ALG10B 0.48 6.97 0.36 1.68e-11 Morning vs. evening chronotype; LUSC cis rs909002 0.800 rs1056526 chr1:32084904 C/T cg01639898 chr1:32083012 HCRTR1 0.31 7.55 0.38 4.22e-13 Intelligence (multi-trait analysis); LUSC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg14019146 chr3:50243930 SLC38A3 -0.36 -8.25 -0.41 3.72e-15 Body mass index; LUSC cis rs13040088 0.872 rs2295481 chr20:61574727 C/T cg23096297 chr20:61557774 DIDO1 0.81 10.57 0.5 9.85e-23 Menopause (age at onset); LUSC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg05234568 chr11:5960015 NA -0.56 -8.15 -0.41 7.16e-15 DNA methylation (variation); LUSC cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.63 0.65 1.01e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs2637266 1.000 rs6480827 chr10:78356333 T/G cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC trans rs13011075 0.919 rs2070171 chr2:68613710 A/G cg14221825 chr19:46271408 SIX5 -0.45 -6.48 -0.33 3.33e-10 Mean corpuscular volume; LUSC trans rs2204008 0.597 rs4002591 chr12:38133841 A/G cg06521331 chr12:34319734 NA -0.4 -6.16 -0.32 2.05e-9 Bladder cancer; LUSC cis rs61931739 0.500 rs7310237 chr12:34483435 G/A cg06521331 chr12:34319734 NA -0.41 -6.73 -0.35 7.4e-11 Morning vs. evening chronotype; LUSC cis rs7296418 0.699 rs11057219 chr12:123750073 T/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.11 -0.41 9.76e-15 Platelet count; LUSC cis rs10782582 0.593 rs2147039 chr1:76143166 C/T cg22875332 chr1:76189707 ACADM -0.41 -6.15 -0.32 2.23e-9 Daytime sleep phenotypes; LUSC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs7072216 0.763 rs2274245 chr10:100175082 C/T cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs11098499 0.954 rs11729521 chr4:120416788 T/C cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC cis rs76878669 0.516 rs7104570 chr11:66159098 A/G cg24851651 chr11:66362959 CCS -0.37 -5.92 -0.31 8.11e-9 Educational attainment (years of education); LUSC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg01097406 chr16:89675127 NA -0.34 -6.77 -0.35 5.89e-11 Vitiligo; LUSC cis rs9549367 0.713 rs4907599 chr13:113861441 C/T cg00898013 chr13:113819073 PROZ 0.54 8.25 0.41 3.7e-15 Platelet distribution width; LUSC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 8.93 0.44 2.88e-17 Schizophrenia; LUSC cis rs6967385 0.560 rs10248602 chr7:12347113 G/C cg06484146 chr7:12443880 VWDE 0.52 7.71 0.39 1.42e-13 Response to taxane treatment (placlitaxel); LUSC cis rs477692 0.905 rs544217 chr10:131420584 A/G cg26102564 chr10:131424627 MGMT 0.36 5.69 0.3 2.74e-8 Response to temozolomide; LUSC trans rs61931739 0.500 rs11053249 chr12:34518834 A/T cg26384229 chr12:38710491 ALG10B 0.91 15.77 0.65 2.76e-42 Morning vs. evening chronotype; LUSC cis rs477692 0.905 rs555545 chr10:131411586 G/A cg05714579 chr10:131428358 MGMT 0.54 8.19 0.41 5.78e-15 Response to temozolomide; LUSC cis rs7186908 0.761 rs34714490 chr16:72177099 G/T cg01557791 chr16:72042693 DHODH -0.51 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6951245 1.000 rs80031817 chr7:1096793 T/C cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg00825309 chr19:58991885 ZNF446 -0.49 -7.1 -0.36 7.49e-12 Uric acid clearance; LUSC cis rs10751667 0.666 rs7394958 chr11:965944 C/G ch.11.42038R chr11:967971 AP2A2 0.43 6.4 0.33 5.39e-10 Alzheimer's disease (late onset); LUSC cis rs12712073 0.845 rs6729966 chr2:100781566 A/G cg22139774 chr2:100720529 AFF3 -0.41 -7.05 -0.36 1.05e-11 Intelligence (multi-trait analysis); LUSC cis rs4478858 0.647 rs1007013 chr1:31710270 C/T cg00250761 chr1:31883323 NA -0.34 -8.34 -0.42 1.95e-15 Alcohol dependence; LUSC cis rs4319547 0.741 rs4758663 chr12:122939483 A/G cg23029597 chr12:123009494 RSRC2 -0.69 -8.95 -0.44 2.5e-17 Body mass index; LUSC cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg07606381 chr6:8435919 SLC35B3 -0.73 -12.17 -0.55 1.85e-28 Motion sickness; LUSC cis rs1160297 0.575 rs6715857 chr2:53097395 T/G cg07782112 chr2:53107842 NA 0.45 7.23 0.37 3.41e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg10351095 chr21:47802916 PCNT 0.43 6.12 0.32 2.64e-9 Testicular germ cell tumor; LUSC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg05425664 chr17:57184151 TRIM37 0.52 7.73 0.39 1.31e-13 Intelligence (multi-trait analysis); LUSC cis rs473651 0.901 rs563282 chr2:239329736 T/C cg08773314 chr2:239334832 ASB1 0.48 10.24 0.49 1.39e-21 Multiple system atrophy; LUSC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg08219700 chr8:58056026 NA -0.46 -6.11 -0.32 2.77e-9 Developmental language disorder (linguistic errors); LUSC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg02079420 chr8:82753780 SNX16 0.4 5.99 0.31 5.57e-9 Diastolic blood pressure; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg25767906 chr1:53392781 SCP2 -0.64 -12.85 -0.58 5.48e-31 Monocyte count; LUSC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg24130564 chr14:104152367 KLC1 -0.48 -7.02 -0.36 1.28e-11 Intelligence (multi-trait analysis); LUSC cis rs55665837 1.000 rs10832271 chr11:14466919 C/G cg05501817 chr11:14380813 RRAS2 -0.4 -6.54 -0.34 2.3e-10 Vitamin D levels; LUSC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.77e-12 Blood metabolite levels; LUSC cis rs1008375 1.000 rs9291659 chr4:17662360 A/C cg16339924 chr4:17578868 LAP3 0.54 8.0 0.4 2.06e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs35883536 0.647 rs11166485 chr1:101048805 G/C cg06223162 chr1:101003688 GPR88 -0.48 -8.83 -0.44 5.88e-17 Monocyte count; LUSC cis rs3772130 1.000 rs35988617 chr3:121432902 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.64 9.28 0.45 2.14e-18 Cognitive performance; LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1878931 0.582 rs9635562 chr16:3416689 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.62 8.48 0.42 7.3e-16 Body mass index (adult); LUSC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs614226 0.935 rs17431717 chr12:120912210 G/A cg01236616 chr12:121019343 POP5 -1.24 -18.03 -0.7 3.19e-51 Type 1 diabetes nephropathy; LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg10729496 chr3:10149963 C3orf24 0.53 7.21 0.37 3.79e-12 Alzheimer's disease; LUSC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg22532475 chr10:104410764 TRIM8 0.28 5.74 0.3 2.18e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.08 -0.4 1.19e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg00750074 chr16:89608354 SPG7 -0.45 -6.77 -0.35 5.96e-11 Multiple myeloma (IgH translocation); LUSC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.65 14.37 0.62 8.8e-37 Hemoglobin concentration; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg04518342 chr5:131593106 PDLIM4 0.45 7.85 0.39 5.88e-14 Breast cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13929079 chr12:49246153 DDX23 -0.46 -6.17 -0.32 2.01e-9 Bipolar disorder and schizophrenia; LUSC cis rs6601450 0.540 rs7824231 chr8:10273958 G/A cg12940923 chr8:10282607 MSRA -0.37 -6.7 -0.34 8.85e-11 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1728785 1.000 rs7195979 chr16:68586801 G/A cg02972257 chr16:68554789 NA -0.53 -6.76 -0.35 6.31e-11 Ulcerative colitis; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.01 0.77 5.62e-67 Prudent dietary pattern; LUSC cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg07061783 chr6:25882402 NA -0.38 -5.86 -0.31 1.12e-8 Blood metabolite levels; LUSC cis rs2070488 0.775 rs2051213 chr3:38560254 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 12.49 0.56 1.22e-29 Electrocardiographic conduction measures; LUSC trans rs61931739 0.890 rs1687020 chr12:34137924 G/C cg13010199 chr12:38710504 ALG10B 0.43 6.73 0.35 7.38e-11 Morning vs. evening chronotype; LUSC cis rs4889855 0.556 rs56873925 chr17:78536611 C/T cg16591659 chr17:78472290 NA 0.33 6.07 0.32 3.46e-9 Fractional excretion of uric acid; LUSC cis rs6542838 0.702 rs4851167 chr2:99496303 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.98 -0.36 1.59e-11 Fear of minor pain; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02501984 chr12:133263946 POLE;PXMP2 -0.58 -6.95 -0.36 1.93e-11 Bipolar disorder and schizophrenia; LUSC cis rs9549367 0.713 rs3024769 chr13:113825601 A/C cg00898013 chr13:113819073 PROZ 0.58 8.63 0.43 2.49e-16 Platelet distribution width; LUSC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg10802521 chr3:52805072 NEK4 0.44 6.26 0.32 1.18e-9 Bipolar disorder; LUSC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg03806693 chr22:41940476 POLR3H 0.98 14.25 0.61 2.6e-36 Vitiligo; LUSC cis rs9796 0.870 rs28501589 chr15:41282534 G/A cg18705301 chr15:41695430 NDUFAF1 -0.41 -7.17 -0.37 4.92e-12 Menopause (age at onset); LUSC cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg04998671 chr14:104000505 TRMT61A 0.39 5.9 0.31 8.86e-9 Reticulocyte count; LUSC cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg24642439 chr20:33292090 TP53INP2 -0.49 -7.42 -0.38 9.53e-13 Glomerular filtration rate (creatinine); LUSC cis rs11122272 0.525 rs61835222 chr1:231537917 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.09 -0.48 4.67e-21 Hemoglobin concentration; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.72 0.39 1.37e-13 Alzheimer's disease; LUSC cis rs7614311 0.636 rs66818634 chr3:63913222 G/A cg22134162 chr3:63841271 THOC7 -0.48 -5.82 -0.3 1.42e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg05347473 chr6:146136440 FBXO30 -0.66 -11.37 -0.53 1.55e-25 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.658 rs10772149 chr12:34285498 A/G cg24313572 chr1:56050060 NA -0.31 -6.49 -0.33 3.13e-10 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.7 0.3 2.64e-8 Menopause (age at onset); LUSC cis rs12579753 0.917 rs10129029 chr12:82180324 G/A cg21231944 chr12:82153410 PPFIA2 -0.38 -5.75 -0.3 2.05e-8 Resting heart rate; LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg01483505 chr11:975446 AP2A2 0.4 5.75 0.3 1.99e-8 Alzheimer's disease (late onset); LUSC cis rs524023 0.874 rs504915 chr11:64464085 T/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.5 -0.5 1.77e-22 Urate levels in obese individuals; LUSC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg19812747 chr11:111475976 SIK2 -0.53 -7.89 -0.4 4.28e-14 Primary sclerosing cholangitis; LUSC trans rs17361889 0.752 rs4721485 chr7:16282473 G/A cg11150683 chr12:114107765 NA 0.34 5.99 0.31 5.55e-9 Pediatric bone mineral content (hip); LUSC cis rs10792830 0.900 rs580887 chr11:85831433 A/T cg07180834 chr11:85838833 NA -0.31 -6.11 -0.32 2.75e-9 Psychosis and Alzheimer's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00881440 chr7:2595255 C7orf27 -0.51 -6.14 -0.32 2.35e-9 Bipolar disorder and schizophrenia; LUSC cis rs2235544 0.565 rs928444 chr1:54473548 C/G cg25741118 chr1:54482237 LDLRAD1 0.29 6.19 0.32 1.79e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs3862435 0.572 rs74480504 chr15:90924025 T/C cg22089800 chr15:90895588 ZNF774 0.59 6.26 0.32 1.21e-9 Response to exercise (triglyceride level interaction); LUSC cis rs367943 0.966 rs451425 chr5:112808637 A/G cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs10197940 0.662 rs6735771 chr2:152273503 G/A cg19508488 chr2:152266495 RIF1 -0.45 -6.51 -0.34 2.81e-10 Lung cancer; LUSC cis rs66887589 0.807 rs7694483 chr4:120405929 T/A cg24375607 chr4:120327624 NA 0.5 7.78 0.39 8.93e-14 Diastolic blood pressure; LUSC cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg03146154 chr1:46216737 IPP 0.49 7.33 0.37 1.74e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg11764359 chr7:65958608 NA -0.7 -10.9 -0.51 6.9e-24 Aortic root size; LUSC cis rs1448094 0.845 rs10863123 chr12:86346254 G/A cg02569458 chr12:86230093 RASSF9 0.43 6.91 0.35 2.46e-11 Major depressive disorder; LUSC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.78 -13.72 -0.6 2.75e-34 Total body bone mineral density; LUSC trans rs3942852 0.955 rs1910364 chr11:48113232 A/G cg03929089 chr4:120376271 NA -0.55 -6.24 -0.32 1.34e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs6942756 1.000 rs67520056 chr7:128982075 A/G cg02491457 chr7:128862824 NA -0.47 -6.38 -0.33 6.02e-10 White matter hyperintensity burden; LUSC cis rs7607369 0.526 rs4674322 chr2:219513782 C/T cg02176678 chr2:219576539 TTLL4 0.7 10.5 0.5 1.75e-22 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs61774743 0.754 rs11581271 chr1:41835061 C/G cg08462924 chr1:41848221 NA 0.37 6.26 0.32 1.2e-9 Intelligence (multi-trait analysis); LUSC cis rs208520 1.000 rs72882100 chr6:66981495 G/C cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs1371867 0.839 rs1660313 chr8:101332712 G/A cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11890956 chr21:40555474 PSMG1 1.03 19.9 0.74 1.11e-58 Cognitive function; LUSC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg02524346 chr8:600233 NA -0.76 -6.75 -0.35 6.43e-11 IgG glycosylation; LUSC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg06219351 chr7:158114137 PTPRN2 -0.54 -8.24 -0.41 4.02e-15 Response to amphetamines; LUSC cis rs7613051 0.945 rs7629880 chr3:33058811 C/T cg19000631 chr3:33138515 GLB1;TMPPE -0.48 -5.72 -0.3 2.31e-8 Atopic dermatitis; LUSC cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg18681998 chr4:17616180 MED28 0.83 15.02 0.63 2.55e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs460214 0.539 rs55819392 chr21:40038207 G/A cg12884169 chr21:40033163 ERG -0.37 -5.93 -0.31 7.46e-9 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.91 0.35 2.49e-11 Parkinson's disease; LUSC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg12257692 chr3:49977190 RBM6 -0.26 -7.17 -0.37 4.71e-12 Intelligence (multi-trait analysis); LUSC trans rs1728785 1.000 rs1069288 chr16:68585285 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.59 0.38 3.31e-13 Ulcerative colitis; LUSC cis rs3947 0.789 rs8005 chr8:11701096 A/C cg00262122 chr8:11665843 FDFT1 0.52 7.05 0.36 1.06e-11 Blood protein levels; LUSC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg00784671 chr22:46762841 CELSR1 -0.49 -6.68 -0.34 1.02e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg21361702 chr7:150065534 REPIN1 0.57 8.02 0.4 1.85e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg27432699 chr2:27873401 GPN1 -0.57 -8.45 -0.42 9.09e-16 Total body bone mineral density; LUSC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg12292205 chr6:26970375 C6orf41 -0.6 -7.36 -0.37 1.47e-12 Intelligence (multi-trait analysis); LUSC trans rs7726558 0.658 rs28943593 chr5:118877566 C/T cg14402224 chr7:50570049 DDC -0.48 -6.06 -0.31 3.67e-9 QT interval (sulfonylurea treatment interaction); LUSC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg13206674 chr6:150067644 NUP43 0.58 8.94 0.44 2.69e-17 Lung cancer; LUSC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg04369109 chr6:150039330 LATS1 -0.58 -8.56 -0.42 4.25e-16 Lung cancer; LUSC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg07424592 chr7:64974309 NA 0.71 6.19 0.32 1.72e-9 Diabetic kidney disease; LUSC cis rs11608355 0.515 rs2241204 chr12:109972037 G/A cg05360138 chr12:110035743 NA 0.93 12.29 0.56 6.89e-29 Neuroticism; LUSC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg09359103 chr1:154839909 KCNN3 -0.74 -18.03 -0.7 3.19e-51 Prostate cancer; LUSC cis rs9393777 0.778 rs4452638 chr6:27229265 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.45 5.82 0.3 1.41e-8 Intelligence (multi-trait analysis); LUSC cis rs2933343 0.700 rs883602 chr3:128653952 A/G cg11901034 chr3:128598214 ACAD9 -0.41 -6.5 -0.34 2.91e-10 IgG glycosylation; LUSC cis rs4555082 0.834 rs28489970 chr14:105748862 T/C cg10792982 chr14:105748885 BRF1 0.5 8.87 0.44 4.48e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg06238570 chr21:40685208 BRWD1 -0.54 -8.55 -0.42 4.58e-16 Menarche (age at onset); LUSC trans rs8072100 0.967 rs11656855 chr17:45714655 C/T cg04995722 chr7:26192034 NFE2L3 0.37 6.16 0.32 2.08e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs7819412 0.521 rs10110684 chr8:11039159 G/C cg15556689 chr8:8085844 FLJ10661 -0.5 -7.03 -0.36 1.2e-11 Triglycerides; LUSC cis rs1003719 0.646 rs2835672 chr21:38581234 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.18 -0.49 2.18e-21 Eye color traits; LUSC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg04025307 chr7:1156635 C7orf50 0.42 6.77 0.35 5.97e-11 Longevity;Endometriosis; LUSC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg20476274 chr7:133979776 SLC35B4 0.86 16.48 0.67 4.59e-45 Mean platelet volume; LUSC cis rs9807989 0.839 rs6749114 chr2:102967587 A/C cg09003973 chr2:102972529 NA 0.44 5.99 0.31 5.43e-9 Asthma; LUSC cis rs9467773 1.000 rs6940053 chr6:26562122 C/T cg09904177 chr6:26538194 HMGN4 0.76 14.16 0.61 5.54e-36 Intelligence (multi-trait analysis); LUSC trans rs8022179 0.580 rs8013228 chr14:103842650 A/G cg17675199 chr6:35436792 RPL10A 0.49 6.34 0.33 7.44e-10 Monocyte count; LUSC cis rs67366981 0.925 rs41438045 chr14:77692781 A/T cg22824376 chr14:77648248 TMEM63C 0.76 7.14 0.36 5.72e-12 Obsessive-compulsive symptoms; LUSC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg22875332 chr1:76189707 ACADM 0.74 9.68 0.47 1.03e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3741151 1.000 rs7941454 chr11:73085336 C/T cg17517138 chr11:73019481 ARHGEF17 0.9 7.87 0.4 4.86e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs6952808 0.692 rs60755037 chr7:2030104 G/A cg04565464 chr8:145669602 NFKBIL2 0.39 6.41 0.33 4.9e-10 Bipolar disorder and schizophrenia; LUSC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg26695010 chr11:65641043 EFEMP2 -0.47 -7.15 -0.36 5.35e-12 Eosinophil percentage of white cells; LUSC cis rs4561483 0.673 rs28279 chr16:11968555 A/C cg08843971 chr16:11963173 GSPT1 0.51 8.01 0.4 1.99e-14 Testicular germ cell tumor; LUSC cis rs950027 0.620 rs1145084 chr15:45675440 G/A cg04036182 chr15:45458818 NA 0.34 5.66 0.3 3.2e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs9937943 0.614 rs35148538 chr16:74613575 G/C cg01733217 chr16:74700730 RFWD3 0.58 6.04 0.31 4.15e-9 Neutrophil percentage of white cells; LUSC cis rs1577917 0.874 rs11756621 chr6:86740063 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.58 -0.42 3.69e-16 Response to antipsychotic treatment; LUSC cis rs2840044 1.000 rs9900378 chr17:33911302 C/T cg05299278 chr17:33885742 SLFN14 -0.3 -6.31 -0.33 8.91e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs593982 1.000 rs576663 chr11:65498942 G/T cg08755490 chr11:65554678 OVOL1 1.41 17.72 0.7 5.44e-50 Atopic dermatitis; LUSC cis rs11971779 0.680 rs6467840 chr7:139065401 A/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg23711669 chr6:146136114 FBXO30 0.77 13.91 0.61 5.14e-35 Lobe attachment (rater-scored or self-reported); LUSC trans rs9329221 0.527 rs34308302 chr8:10332022 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.55 -0.34 2.19e-10 Neuroticism; LUSC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg00800038 chr16:89945340 TCF25 -0.76 -6.58 -0.34 1.78e-10 Skin colour saturation; LUSC trans rs2243480 1.000 rs6460261 chr7:65215580 T/C cg10756647 chr7:56101905 PSPH -0.83 -8.16 -0.41 7.1e-15 Diabetic kidney disease; LUSC trans rs9944715 0.954 rs9952469 chr18:43812010 T/C cg01718231 chr17:29326311 RNF135 -0.52 -7.35 -0.37 1.52e-12 Red cell distribution width;Mean corpuscular volume; LUSC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg21775007 chr8:11205619 TDH -0.48 -7.22 -0.37 3.6e-12 Neuroticism; LUSC cis rs2303282 0.716 rs7203090 chr16:56444439 C/T cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.88e-12 Breast cancer; LUSC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.44 0.33 4.14e-10 Lung cancer; LUSC trans rs8002861 0.664 rs4941474 chr13:44450289 C/T cg12856521 chr11:46389249 DGKZ 0.41 6.33 0.33 7.96e-10 Leprosy; LUSC cis rs17092148 0.887 rs6058077 chr20:33140999 G/A cg16810054 chr20:33298113 TP53INP2 -0.36 -5.69 -0.3 2.73e-8 Neuroticism; LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg24642844 chr7:1081250 C7orf50 -0.8 -11.08 -0.52 1.72e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1003719 0.788 rs7277657 chr21:38469523 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg18876405 chr7:65276391 NA 0.68 12.02 0.55 6.86e-28 Aortic root size; LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg02018176 chr4:1364513 KIAA1530 0.52 9.06 0.44 1.13e-17 Obesity-related traits; LUSC cis rs2439831 0.867 rs12443102 chr15:43932103 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.74 7.25 0.37 2.87e-12 Lung cancer in ever smokers; LUSC cis rs500891 0.525 rs1170466 chr6:84025802 C/T cg08257003 chr6:84140564 ME1 0.33 7.11 0.36 6.96e-12 Platelet-derived growth factor BB levels; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.5 -6.85 -0.35 3.57e-11 Renal function-related traits (BUN); LUSC cis rs11250098 0.503 rs13270870 chr8:10770782 A/G cg21775007 chr8:11205619 TDH -0.49 -6.69 -0.34 9.61e-11 Morning vs. evening chronotype; LUSC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs2797160 1.000 rs1832980 chr6:125997444 T/G cg05901451 chr6:126070800 HEY2 -0.59 -8.91 -0.44 3.44e-17 Endometrial cancer; LUSC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.5 -7.74 -0.39 1.21e-13 Prudent dietary pattern; LUSC cis rs11229555 0.645 rs12274866 chr11:58177129 C/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9457247 0.602 rs6456152 chr6:167472062 A/G cg07741184 chr6:167504864 NA 0.49 8.55 0.42 4.6e-16 Crohn's disease; LUSC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg00343986 chr7:65444356 GUSB 0.44 6.79 0.35 5.23e-11 Aortic root size; LUSC cis rs12478296 0.901 rs67423532 chr2:243004719 A/G cg06360820 chr2:242988706 NA -0.83 -9.71 -0.47 8.58e-20 Obesity-related traits; LUSC cis rs73206853 0.841 rs56017652 chr12:110931054 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2859741 0.546 rs2133910 chr1:37478785 G/T cg09363841 chr1:37513479 NA -0.4 -7.69 -0.39 1.64e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC trans rs12637928 0.560 rs11706216 chr3:110220349 C/T cg17371621 chr15:61264283 RORA 0.37 6.13 0.32 2.43e-9 Neuroticism; LUSC cis rs4704187 0.595 rs7717337 chr5:74377001 T/C cg03227963 chr5:74354835 NA 0.31 6.78 0.35 5.4e-11 Response to amphetamines; LUSC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg00484396 chr16:3507460 NAT15 0.71 12.45 0.56 1.69e-29 Tuberculosis; LUSC cis rs11625487 0.957 rs28820314 chr14:77963272 A/C cg20045696 chr14:77926864 AHSA1 -0.48 -6.45 -0.33 3.99e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg04166393 chr7:2884313 GNA12 0.42 5.92 0.31 8.2e-9 Height; LUSC cis rs500891 0.818 rs13220730 chr6:84092546 T/C cg08257003 chr6:84140564 ME1 0.33 6.91 0.35 2.5e-11 Platelet-derived growth factor BB levels; LUSC cis rs10779751 0.770 rs2791643 chr1:11207269 C/T cg08854313 chr1:11322531 MTOR 0.84 13.21 0.59 2.37e-32 Body mass index; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg01585723 chr16:33734837 NA 0.47 8.09 0.4 1.11e-14 Menopause (age at onset); LUSC trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg13615516 chr5:77269221 NA 0.39 6.62 0.34 1.39e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.644 rs7676296 chr4:120555687 A/G cg09307838 chr4:120376055 NA 0.63 9.47 0.46 5.11e-19 Corneal astigmatism; LUSC cis rs7945705 0.837 rs10769966 chr11:8847041 C/A cg21881798 chr11:8931708 C11orf17;ST5 0.47 8.79 0.43 8.13e-17 Hemoglobin concentration; LUSC trans rs995000 0.931 rs626787 chr1:62901243 C/G cg11384718 chr3:121553940 IQCB1;EAF2 0.4 6.15 0.32 2.18e-9 Triglyceride levels; LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg25072359 chr17:41440525 NA 0.64 9.02 0.44 1.51e-17 Menopause (age at onset); LUSC cis rs12497850 1.000 rs12497850 chr3:48748989 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.39 0.42 1.43e-15 Parkinson's disease; LUSC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg01097406 chr16:89675127 NA -0.38 -7.73 -0.39 1.32e-13 Vitiligo; LUSC cis rs12908161 0.920 rs35758837 chr15:85311382 C/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.66 0.34 1.15e-10 Schizophrenia; LUSC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg18230493 chr5:56204884 C5orf35 0.5 7.95 0.4 2.94e-14 Breast cancer;Breast cancer (early onset); LUSC cis rs2933343 0.729 rs1683816 chr3:128651195 G/T cg11901034 chr3:128598214 ACAD9 0.4 6.18 0.32 1.86e-9 IgG glycosylation; LUSC cis rs67460515 0.892 rs4856757 chr3:160999418 A/T cg03342759 chr3:160939853 NMD3 -0.54 -7.97 -0.4 2.52e-14 Parkinson's disease; LUSC cis rs662064 0.852 rs616402 chr1:10566272 C/T cg20482658 chr1:10539492 PEX14 0.28 5.86 0.31 1.12e-8 Asthma; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg27535305 chr1:53392650 SCP2 -0.39 -7.46 -0.38 7.42e-13 Monocyte count; LUSC cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg22681709 chr2:178499509 PDE11A -0.34 -6.19 -0.32 1.72e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg06238570 chr21:40685208 BRWD1 -0.52 -7.85 -0.39 5.83e-14 Menarche (age at onset); LUSC cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg23992470 chr4:843637 GAK 0.58 6.29 0.33 1e-9 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.546 rs599083 chr11:68192346 T/G cg20283391 chr11:68216788 NA -0.53 -7.27 -0.37 2.53e-12 Total body bone mineral density; LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs1505368 0.781 rs10197836 chr2:213274278 T/C cg16329650 chr2:213403929 ERBB4 0.54 8.55 0.42 4.44e-16 Symmetrical dimethylarginine levels; LUSC cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg24692254 chr21:30365293 RNF160 -0.79 -14.41 -0.62 6.25e-37 Dental caries; LUSC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg19592336 chr6:28129416 ZNF389 0.48 6.3 0.33 9.46e-10 Depression; LUSC cis rs7188861 0.768 rs7184969 chr16:11397206 C/A cg00044050 chr16:11439710 C16orf75 0.54 6.04 0.31 4.17e-9 HDL cholesterol; LUSC cis rs672059 1.000 rs480132 chr1:183161779 A/G ch.1.3577855R chr1:183094577 LAMC1 0.55 8.06 0.4 1.37e-14 Hypertriglyceridemia; LUSC cis rs7582180 0.629 rs11686799 chr2:100956055 C/G cg08017756 chr2:100939284 LONRF2 -0.47 -8.64 -0.43 2.36e-16 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14945867 chr14:54908007 CNIH 0.45 6.17 0.32 1.95e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs679087 0.686 rs10843500 chr12:29918582 C/G cg14258853 chr12:29935411 TMTC1 0.68 10.55 0.5 1.22e-22 Schizophrenia; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg22638593 chr5:131593259 PDLIM4 0.39 5.76 0.3 1.91e-8 Breast cancer; LUSC cis rs2295359 0.824 rs12060309 chr1:67604219 T/C cg12940439 chr1:67600707 NA 0.36 5.81 0.3 1.43e-8 Psoriasis; LUSC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs1371867 0.846 rs1660324 chr8:101281271 C/T cg06636551 chr8:101224915 SPAG1 -0.44 -7.97 -0.4 2.5e-14 Atrioventricular conduction; LUSC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg10053473 chr17:62856997 LRRC37A3 -0.67 -10.43 -0.5 3.07e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 7.89e-25 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg18404041 chr3:52824283 ITIH1 -0.58 -9.62 -0.47 1.75e-19 Schizophrenia; LUSC cis rs308403 0.568 rs13120869 chr4:123646152 T/C cg10495464 chr4:123653540 BBS12;LOC729338 0.8 10.22 0.49 1.61e-21 Blood protein levels; LUSC trans rs10411161 0.702 rs8113685 chr19:52383890 C/T cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs7100689 0.646 rs1934694 chr10:82125325 G/A cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs655601 0.643 rs112702671 chr5:180220930 C/T cg13724780 chr5:180237085 MGAT1 1.06 8.0 0.4 2.1e-14 Quantitative traits; LUSC cis rs7949030 0.754 rs36104523 chr11:62395740 A/T cg13298116 chr11:62369859 EML3;MTA2 -0.52 -8.89 -0.44 3.75e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13242816 1.000 rs35364754 chr7:116109716 T/G cg16553024 chr7:116138462 CAV2 -0.54 -5.92 -0.31 7.84e-9 P wave duration; LUSC cis rs7818345 0.845 rs4256608 chr8:19267560 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 5.97 0.31 6.05e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg21856205 chr7:94953877 PON1 -0.35 -5.74 -0.3 2.09e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs73198271 0.562 rs55657655 chr8:8675491 G/A cg01851573 chr8:8652454 MFHAS1 0.65 8.45 0.42 8.99e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11105298 0.891 rs11105325 chr12:89938590 G/A cg00757033 chr12:89920650 WDR51B 0.6 10.42 0.5 3.48e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs61931739 0.679 rs10844831 chr12:34311245 G/T cg24313572 chr1:56050060 NA -0.31 -6.33 -0.33 7.99e-10 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2067615 0.579 rs1811458 chr12:107203683 G/A cg15890332 chr12:107067104 RFX4 0.34 6.18 0.32 1.91e-9 Heart rate; LUSC cis rs116988415 0.584 rs77490765 chr14:65278537 T/G cg00114569 chr14:65239327 SPTB 0.7 7.21 0.37 3.75e-12 Daytime sleep phenotypes; LUSC cis rs2425143 0.514 rs8114246 chr20:34581979 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -6.3 -0.33 9.16e-10 Blood protein levels; LUSC cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -14.3 -0.62 1.55e-36 Chronic sinus infection; LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg23625390 chr15:77176239 SCAPER 0.46 7.02 0.36 1.25e-11 Blood metabolite levels; LUSC cis rs10911363 0.615 rs9286848 chr1:183426249 C/G cg09173681 chr1:183549694 NCF2 -0.63 -11.13 -0.52 1.12e-24 Systemic lupus erythematosus; LUSC cis rs9309473 0.948 rs13392691 chr2:73748980 G/A cg20560298 chr2:73613845 ALMS1 -0.51 -7.31 -0.37 2e-12 Metabolite levels; LUSC cis rs17253792 0.822 rs113649689 chr14:56088065 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs1348850 0.651 rs4893936 chr2:178240676 C/G cg22681709 chr2:178499509 PDE11A -0.35 -6.48 -0.33 3.22e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg06212747 chr3:49208901 KLHDC8B 0.45 6.12 0.32 2.58e-9 Parkinson's disease; LUSC cis rs2115536 0.692 rs6495451 chr15:80164053 C/T cg02196730 chr15:80188777 MTHFS 0.4 6.01 0.31 4.8e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg08392591 chr16:89556376 ANKRD11 0.42 6.25 0.32 1.26e-9 Multiple myeloma (IgH translocation); LUSC cis rs10089 0.953 rs6887674 chr5:127531183 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.85 10.22 0.49 1.68e-21 Ileal carcinoids; LUSC cis rs9326248 0.509 rs533556 chr11:116741572 A/C cg26566898 chr11:117069891 TAGLN 0.36 7.02 0.36 1.24e-11 Blood protein levels; LUSC cis rs8014204 0.781 rs10143492 chr14:75212114 G/C cg08847533 chr14:75593920 NEK9 0.4 5.64 0.3 3.57e-8 Caffeine consumption; LUSC cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.8 -0.43 7.27e-17 Monocyte percentage of white cells; LUSC cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg09469691 chr10:81107165 PPIF 0.7 10.75 0.51 2.35e-23 Height; LUSC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg19748678 chr4:122722346 EXOSC9 0.74 11.15 0.52 9.56e-25 Type 2 diabetes; LUSC cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg01884057 chr2:25150051 NA 0.46 10.58 0.5 9.55e-23 Body mass index; LUSC cis rs3750965 0.959 rs2253658 chr11:68856804 C/G cg06818126 chr11:68850279 TPCN2 -0.44 -6.42 -0.33 4.7e-10 Hair color; LUSC cis rs12421382 0.659 rs1371332 chr11:109381687 A/T cg16359550 chr11:109292809 C11orf87 0.38 6.47 0.33 3.46e-10 Schizophrenia; LUSC trans rs877282 1.000 rs11253361 chr10:770387 T/C cg13042288 chr15:90349979 ANPEP -0.47 -6.73 -0.35 7.27e-11 Uric acid levels; LUSC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg05623727 chr3:50126028 RBM5 -0.35 -6.55 -0.34 2.14e-10 Intelligence (multi-trait analysis); LUSC cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg07148914 chr20:33460835 GGT7 -0.53 -8.1 -0.41 1.05e-14 Glomerular filtration rate (creatinine); LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18758796 chr5:131593413 PDLIM4 0.47 7.78 0.39 9.31e-14 Acylcarnitine levels; LUSC cis rs2637266 0.655 rs7902535 chr10:78460889 C/T cg18941641 chr10:78392320 NA 0.34 5.96 0.31 6.58e-9 Pulmonary function; LUSC cis rs7103648 1.000 rs7103648 chr11:47461783 A/G cg20307385 chr11:47447363 PSMC3 0.99 19.44 0.73 7.79e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg24450063 chr1:156163899 SLC25A44 1.06 17.28 0.69 3.12e-48 Testicular germ cell tumor; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg00431813 chr7:1051703 C7orf50 -0.46 -7.55 -0.38 4.26e-13 Longevity;Endometriosis; LUSC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.39 7.48 0.38 6.47e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -5.71 -0.3 2.44e-8 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24845578 chr5:95170808 NA -0.39 -6.28 -0.32 1.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.51 0.62 2.44e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12472274 0.646 rs35468889 chr2:239090959 G/A cg17459225 chr2:239074497 NA 0.54 7.39 0.37 1.19e-12 Phospholipid levels (plasma); LUSC cis rs6545883 0.801 rs778142 chr2:61681428 G/T cg15711740 chr2:61764176 XPO1 -0.43 -6.41 -0.33 5.01e-10 Tuberculosis; LUSC trans rs9291683 0.530 rs6449196 chr4:9973660 C/T cg26043149 chr18:55253948 FECH -0.46 -6.95 -0.36 1.88e-11 Bone mineral density; LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.967 rs10863118 chr12:86339232 C/G cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.56e-9 Major depressive disorder; LUSC cis rs16937 0.711 rs12130817 chr1:205140305 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.5 0.34 2.93e-10 Schizophrenia; LUSC cis rs2486288 0.656 rs7165039 chr15:45570413 C/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.7 -0.39 1.6e-13 Glomerular filtration rate; LUSC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg03188948 chr7:1209495 NA 0.61 6.95 0.36 1.88e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs981844 0.736 rs1036614 chr4:154639105 G/A cg14289246 chr4:154710475 SFRP2 0.47 5.83 0.3 1.32e-8 Response to statins (LDL cholesterol change); LUSC cis rs2204008 0.577 rs2623049 chr12:38018831 G/A cg13010199 chr12:38710504 ALG10B -0.61 -9.5 -0.46 4.12e-19 Bladder cancer; LUSC cis rs4077515 0.874 rs3812575 chr9:139293259 T/C cg14169450 chr9:139327907 INPP5E 0.44 7.94 0.4 3.07e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs422249 0.512 rs174568 chr11:61593816 C/T cg19610905 chr11:61596333 FADS2 -0.55 -8.31 -0.41 2.39e-15 Trans fatty acid levels; LUSC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Parkinson's disease; LUSC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4132509 0.744 rs10927065 chr1:243914611 G/T cg21452805 chr1:244014465 NA 0.6 6.75 0.35 6.49e-11 RR interval (heart rate); LUSC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg22433210 chr17:43662623 NA -0.74 -10.81 -0.51 1.43e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs240993 0.595 rs3777911 chr6:111902480 G/C cg22127309 chr6:111907043 TRAF3IP2 0.34 6.12 0.32 2.69e-9 Inflammatory skin disease;Psoriasis; LUSC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg08499158 chr17:42289980 UBTF 0.4 6.23 0.32 1.41e-9 Total body bone mineral density; LUSC cis rs7336332 0.598 rs45622135 chr13:28011594 T/C cg22138327 chr13:27999177 GTF3A 0.81 10.14 0.49 2.98e-21 Weight; LUSC cis rs11229555 0.645 rs7930547 chr11:58197616 A/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12618546 chr1:32817463 NA -0.42 -6.57 -0.34 1.88e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs35110281 0.641 rs9983670 chr21:45083425 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 9.98 0.48 1.09e-20 Mean corpuscular volume; LUSC cis rs796825 0.530 rs55861253 chr3:119986807 A/G cg21790991 chr3:120137480 FSTL1 -0.34 -6.1 -0.32 2.93e-9 HIV-1 susceptibility; LUSC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg06671706 chr8:8559999 CLDN23 0.47 6.4 0.33 5.34e-10 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12230071 chr15:65822924 PTPLAD1 0.46 6.86 0.35 3.33e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs35110281 0.811 rs2838337 chr21:45072621 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.67 11.96 0.55 1.11e-27 Mean corpuscular volume; LUSC cis rs17253792 0.822 rs10483645 chr14:56103766 G/T cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.28e-10 Putamen volume; LUSC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg15110403 chr19:17392923 ANKLE1 -0.52 -7.15 -0.36 5.67e-12 Systemic lupus erythematosus; LUSC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg26380479 chr7:97908229 NA -0.28 -6.0 -0.31 5.07e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9325144 0.560 rs10785586 chr12:38676197 G/A cg13010199 chr12:38710504 ALG10B -0.51 -7.66 -0.39 1.98e-13 Morning vs. evening chronotype; LUSC cis rs4243830 0.850 rs1064835 chr1:6585539 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.71 8.75 0.43 1.09e-16 Body mass index; LUSC cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.14e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.747 rs1413849 chr1:152970233 C/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.46 -0.38 7.47e-13 Inflammatory skin disease; LUSC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg18252515 chr7:66147081 NA 1.2 13.62 0.6 6.4e-34 Diabetic kidney disease; LUSC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.49 -6.74 -0.35 7.02e-11 Alzheimer's disease (late onset); LUSC cis rs6736093 0.763 rs11690440 chr2:112820109 G/A cg12686935 chr2:112915763 FBLN7 -0.41 -6.52 -0.34 2.58e-10 Coronary artery disease; LUSC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg00509249 chr6:109615579 CCDC162 -0.32 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg23649088 chr2:200775458 C2orf69 -0.53 -7.13 -0.36 6.41e-12 Schizophrenia; LUSC cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.45 6.48 0.33 3.22e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs782590 0.967 rs62165173 chr2:55741666 T/C cg03859395 chr2:55845619 SMEK2 0.87 16.19 0.66 6.22e-44 Metabolic syndrome; LUSC cis rs2692947 0.667 rs4144055 chr2:96647856 G/T cg22654517 chr2:96458247 NA 0.32 6.22 0.32 1.49e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9399135 0.967 rs9389251 chr6:135325717 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Red blood cell count; LUSC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg11663144 chr21:46675770 NA -0.34 -5.65 -0.3 3.53e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3770081 1.000 rs74733602 chr2:86303442 T/A cg23655155 chr2:86332777 POLR1A;PTCD3 -1.08 -6.95 -0.36 1.94e-11 Facial emotion recognition (sad faces); LUSC cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.34 -6.27 -0.32 1.09e-9 IgG glycosylation; LUSC cis rs13242816 1.000 rs34424131 chr7:116119002 G/A cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs7590368 1.000 rs55771723 chr2:10961902 T/C cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14240646 chr10:27532245 ACBD5 -0.66 -7.7 -0.39 1.55e-13 Breast cancer; LUSC cis rs829883 0.664 rs1096148 chr12:98851005 A/G cg25150519 chr12:98850993 NA 0.83 14.13 0.61 7.1e-36 Colorectal adenoma (advanced); LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg12564285 chr5:131593104 PDLIM4 -0.52 -9.42 -0.46 7.55e-19 Acylcarnitine levels; LUSC trans rs61931739 0.500 rs11052966 chr12:34019826 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.94 0.51 5.15e-24 Morning vs. evening chronotype; LUSC trans rs35110281 0.720 rs162372 chr21:44928863 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.66 -11.48 -0.53 6.18e-26 Mean corpuscular volume; LUSC cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg06552810 chr11:31128660 NA -0.42 -7.24 -0.37 3.07e-12 Red blood cell count; LUSC cis rs2439831 0.850 rs524417 chr15:43772374 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.77 0.43 9.04e-17 Lung cancer in ever smokers; LUSC cis rs11190604 1.000 rs7099965 chr10:102301165 A/G cg07080220 chr10:102295463 HIF1AN 0.69 9.22 0.45 3.53e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg26384229 chr12:38710491 ALG10B -0.83 -15.55 -0.65 2.11e-41 Heart rate; LUSC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.45 6.48 0.33 3.31e-10 Personality dimensions; LUSC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg03433033 chr1:76189801 ACADM 0.76 10.15 0.49 2.8e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg09650180 chr20:62225654 GMEB2 -0.67 -9.62 -0.47 1.68e-19 Glioblastoma; LUSC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.77 -0.35 5.74e-11 Alzheimer's disease (late onset); LUSC cis rs2953174 0.786 rs2953145 chr2:241515596 C/G cg07929629 chr2:241523174 NA -0.48 -7.45 -0.38 7.93e-13 Bipolar disorder; LUSC cis rs9303280 0.836 rs12453507 chr17:38053207 C/G cg10909506 chr17:38081995 ORMDL3 0.33 5.77 0.3 1.81e-8 Self-reported allergy; LUSC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg01181863 chr3:195395398 SDHAP2 -0.61 -8.37 -0.42 1.64e-15 Pancreatic cancer; LUSC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg05313129 chr8:58192883 C8orf71 -0.44 -6.18 -0.32 1.92e-9 Developmental language disorder (linguistic errors); LUSC cis rs2236918 0.932 rs1776178 chr1:242011534 C/T cg17736920 chr1:242011382 EXO1 -0.45 -7.36 -0.37 1.44e-12 Menopause (age at onset); LUSC cis rs72781680 0.706 rs72796108 chr2:23904990 C/A cg20701182 chr2:24300061 SF3B14 0.72 6.99 0.36 1.54e-11 Lymphocyte counts; LUSC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg03576123 chr11:487126 PTDSS2 -0.47 -5.77 -0.3 1.77e-8 Systemic lupus erythematosus; LUSC cis rs11122272 0.735 rs2066140 chr1:231504311 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.19 -0.49 2.13e-21 Hemoglobin concentration; LUSC cis rs500891 0.525 rs36116892 chr6:84087567 T/A cg08257003 chr6:84140564 ME1 0.34 8.16 0.41 6.84e-15 Platelet-derived growth factor BB levels; LUSC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.09 -0.4 1.1e-14 Lung cancer; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg01125463 chr6:42946178 PEX6 -0.36 -5.84 -0.3 1.23e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2180341 0.618 rs12529077 chr6:127634244 G/T cg27446573 chr6:127587934 RNF146 0.64 10.28 0.49 1.03e-21 Breast cancer; LUSC trans rs208520 0.802 rs208496 chr6:66930786 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -13.89 -0.61 5.93e-35 Exhaled nitric oxide output; LUSC cis rs614226 0.516 rs1794748 chr12:120953758 A/G cg27489772 chr12:121021490 NA 0.58 7.75 0.39 1.11e-13 Type 1 diabetes nephropathy; LUSC cis rs13082711 0.911 rs997680 chr3:27443638 G/A cg02860705 chr3:27208620 NA 0.46 7.71 0.39 1.42e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg08470875 chr2:26401718 FAM59B 0.75 9.99 0.48 1e-20 Gut microbiome composition (summer); LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg18765753 chr7:1198926 ZFAND2A -0.47 -8.32 -0.41 2.32e-15 Longevity;Endometriosis; LUSC cis rs3820068 0.655 rs59605679 chr1:15863796 T/G cg17385448 chr1:15911702 AGMAT 0.38 5.91 0.31 8.64e-9 Systolic blood pressure; LUSC cis rs10870270 1.000 rs7098014 chr10:133775029 G/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.26 -0.45 2.47e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg15839431 chr19:19639596 YJEFN3 -0.57 -6.13 -0.32 2.48e-9 Bipolar disorder; LUSC cis rs13256369 0.950 rs1522839 chr8:8580453 C/T cg18904891 chr8:8559673 CLDN23 0.55 7.18 0.37 4.47e-12 Obesity-related traits; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.32 0.77 3.6e-68 Prudent dietary pattern; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05407825 chr18:2571088 NDC80;METTL4 0.67 6.11 0.32 2.73e-9 Cognitive performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16717740 chr19:19612870 GATAD2A 0.38 6.04 0.31 4.17e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg04317338 chr11:64019027 PLCB3 0.68 7.75 0.39 1.12e-13 Attention deficit hyperactivity disorder; LUSC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19717773 chr7:2847554 GNA12 -0.38 -6.2 -0.32 1.65e-9 Height; LUSC cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg19418458 chr7:158789849 NA 0.49 8.04 0.4 1.57e-14 Facial morphology (factor 20); LUSC cis rs6977660 0.714 rs10270468 chr7:19810559 T/C cg05791153 chr7:19748676 TWISTNB 0.66 7.04 0.36 1.11e-11 Thyroid stimulating hormone; LUSC cis rs7017697 0.507 rs10112790 chr8:19684414 A/T cg03894339 chr8:19674705 INTS10 -0.55 -7.2 -0.37 3.9e-12 Breast cancer; LUSC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg06618935 chr21:46677482 NA -0.37 -7.12 -0.36 6.83e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs951366 0.539 rs1935025 chr1:205692084 C/A cg11965913 chr1:205819406 PM20D1 -0.48 -6.7 -0.34 8.63e-11 Menarche (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11234017 chr17:42767172 CCDC43 0.44 6.53 0.34 2.46e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1448094 0.785 rs7955173 chr12:86447214 G/A cg00310523 chr12:86230176 RASSF9 -0.35 -6.3 -0.33 9.24e-10 Major depressive disorder; LUSC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg11742103 chr11:62369870 EML3;MTA2 0.55 9.01 0.44 1.57e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg04576048 chr1:205797593 PM20D1 0.33 6.05 0.31 3.88e-9 Menarche (age at onset); LUSC cis rs4622329 0.615 rs4764676 chr12:102289957 T/C cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC cis rs6912958 0.712 rs2787927 chr6:88412786 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.76 -0.35 6.1e-11 Monocyte percentage of white cells; LUSC cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg13010199 chr12:38710504 ALG10B 0.67 10.27 0.49 1.1e-21 Bladder cancer; LUSC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg18876405 chr7:65276391 NA 0.54 8.23 0.41 4.27e-15 Aortic root size; LUSC cis rs35883536 1.000 rs4907921 chr1:101128249 C/T cg06223162 chr1:101003688 GPR88 0.32 5.79 0.3 1.62e-8 Monocyte count; LUSC cis rs35146811 0.844 rs4729576 chr7:99692594 G/A cg13334819 chr7:99746414 C7orf59 -0.43 -5.75 -0.3 2.01e-8 Coronary artery disease; LUSC cis rs9911578 0.757 rs4793954 chr17:56629527 G/T cg12560992 chr17:57184187 TRIM37 -0.75 -11.78 -0.54 4.92e-27 Intelligence (multi-trait analysis); LUSC cis rs981844 0.740 rs1020702 chr4:154685712 A/C cg14289246 chr4:154710475 SFRP2 -0.52 -7.41 -0.38 1.06e-12 Response to statins (LDL cholesterol change); LUSC cis rs7674212 0.539 rs6854709 chr4:104129786 A/G cg16532752 chr4:104119610 CENPE -0.45 -6.86 -0.35 3.42e-11 Type 2 diabetes; LUSC cis rs77106637 0.860 rs1552224 chr11:72433098 A/C cg03713592 chr11:72463424 ARAP1 1.01 11.41 0.53 1.14e-25 Type 2 diabetes; LUSC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg00129232 chr17:37814104 STARD3 -0.41 -5.91 -0.31 8.22e-9 Asthma; LUSC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.69 -0.47 1.01e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 13.79 0.6 1.44e-34 Smoking behavior; LUSC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg23172400 chr8:95962367 TP53INP1 -0.38 -7.62 -0.38 2.68e-13 Type 2 diabetes; LUSC trans rs7939886 0.920 rs74459856 chr11:56027689 G/A cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg18352616 chr4:3374830 RGS12 0.31 6.12 0.32 2.61e-9 Serum sulfate level; LUSC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg16325326 chr1:53192061 ZYG11B 0.88 15.8 0.65 2.19e-42 Monocyte count; LUSC cis rs6977660 0.619 rs12530799 chr7:19782793 G/A cg05791153 chr7:19748676 TWISTNB 0.69 7.18 0.37 4.5e-12 Thyroid stimulating hormone; LUSC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.79e-8 Depression; LUSC cis rs10498514 0.793 rs116953714 chr14:65054966 C/T cg25134081 chr14:64931936 AKAP5 0.98 6.74 0.35 7.01e-11 Cognitive performance; LUSC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg21724239 chr8:58056113 NA 0.78 9.38 0.46 1.06e-18 Developmental language disorder (linguistic errors); LUSC cis rs2839186 0.867 rs13050387 chr21:47701423 C/T cg13126279 chr21:47581558 C21orf56 -0.42 -6.17 -0.32 1.93e-9 Testicular germ cell tumor; LUSC trans rs7939886 0.920 rs78769647 chr11:55965527 C/T cg03929089 chr4:120376271 NA 0.81 6.11 0.32 2.73e-9 Myopia (pathological); LUSC cis rs7107174 0.901 rs2912 chr11:77926292 G/A cg02023728 chr11:77925099 USP35 0.52 7.01 0.36 1.3e-11 Testicular germ cell tumor; LUSC cis rs10189230 0.904 rs13029372 chr2:222348434 A/G cg14652038 chr2:222343519 EPHA4 0.37 6.45 0.33 3.94e-10 Urate levels in lean individuals; LUSC cis rs10927875 0.662 rs698893 chr1:16302982 C/T cg22431228 chr1:16359049 CLCNKA -0.43 -8.86 -0.44 4.89e-17 Dilated cardiomyopathy; LUSC cis rs892961 0.932 rs2170863 chr17:75415037 C/T cg05865280 chr17:75406074 SEPT9 0.46 9.63 0.47 1.54e-19 Airflow obstruction; LUSC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg06046430 chr4:77819534 ANKRD56 0.48 6.94 0.35 2.06e-11 Emphysema distribution in smoking; LUSC cis rs6598955 0.671 rs12089149 chr1:26638500 C/A cg00852783 chr1:26633632 UBXN11 -0.5 -5.73 -0.3 2.21e-8 Obesity-related traits; LUSC cis rs11758351 0.587 rs10484436 chr6:26237155 C/T cg01420254 chr6:26195488 NA 0.66 7.19 0.37 4.38e-12 Gout;Renal underexcretion gout; LUSC cis rs6977940 0.730 rs11768001 chr7:2887783 T/C cg19731401 chr7:2775893 GNA12 0.7 7.58 0.38 3.54e-13 White matter integrity; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs7246967 0.551 rs7248993 chr19:22849152 G/C cg23217946 chr19:22817039 ZNF492 0.49 6.87 0.35 3.18e-11 Bronchopulmonary dysplasia; LUSC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg08847533 chr14:75593920 NEK9 0.85 15.86 0.66 1.33e-42 Height; LUSC cis rs3126085 0.935 rs4845740 chr1:152183310 G/A cg26876637 chr1:152193138 HRNR 0.43 6.06 0.31 3.62e-9 Atopic dermatitis; LUSC cis rs4409675 0.576 rs2749110 chr1:28235010 T/C cg23691781 chr1:28212827 C1orf38 0.33 7.92 0.4 3.62e-14 Corneal astigmatism; LUSC cis rs6460942 0.908 rs112897715 chr7:12241541 T/C cg06484146 chr7:12443880 VWDE -0.6 -6.26 -0.32 1.21e-9 Coronary artery disease; LUSC cis rs1712517 0.771 rs11191654 chr10:105077124 C/A cg05636881 chr10:105038444 INA 0.39 6.39 0.33 5.47e-10 Migraine; LUSC cis rs7011049 1.000 rs11997775 chr8:53833571 C/T cg26025543 chr8:53854495 NA -0.48 -5.92 -0.31 8.08e-9 Systolic blood pressure; LUSC cis rs4704187 0.663 rs6889760 chr5:74503704 A/C cg03227963 chr5:74354835 NA 0.3 6.64 0.34 1.24e-10 Response to amphetamines; LUSC cis rs8060686 0.591 rs255054 chr16:68017356 A/G cg05110241 chr16:68378359 PRMT7 -0.55 -6.39 -0.33 5.58e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.75 0.3 2.03e-8 Schizophrenia; LUSC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg20476274 chr7:133979776 SLC35B4 0.87 16.89 0.68 1.02e-46 Mean platelet volume; LUSC cis rs3862435 0.764 rs78896416 chr15:90993016 G/A cg22089800 chr15:90895588 ZNF774 0.57 5.97 0.31 5.95e-9 Response to exercise (triglyceride level interaction); LUSC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg11843238 chr5:131593191 PDLIM4 -0.38 -6.3 -0.33 9.24e-10 Breast cancer; LUSC cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg24596788 chr1:163392923 NA -0.45 -7.59 -0.38 3.27e-13 Motion sickness; LUSC cis rs3806843 0.576 rs246062 chr5:140324580 T/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.78 10.67 0.5 4.71e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6960043 0.818 rs10244051 chr7:15063833 T/G cg19272540 chr7:15055459 NA -0.31 -7.6 -0.38 2.92e-13 Type 2 diabetes; LUSC cis rs7771547 0.573 rs547026 chr6:36398616 G/A cg07856975 chr6:36356162 ETV7 0.34 6.17 0.32 1.93e-9 Platelet distribution width; LUSC cis rs10752881 0.967 rs4652757 chr1:182974750 T/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs3812111 0.510 rs9372453 chr6:116583872 T/A cg18828861 chr6:116576566 TSPYL4 0.38 6.74 0.35 7e-11 Age-related macular degeneration; LUSC cis rs637571 0.565 rs570387 chr11:65637076 T/C cg17985854 chr11:65770987 BANF1;EIF1AD -0.47 -8.4 -0.42 1.31e-15 Eosinophil percentage of white cells; LUSC cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg26587870 chr6:27730563 NA -0.61 -5.79 -0.3 1.62e-8 Breast cancer; LUSC cis rs6674970 0.933 rs12134957 chr1:151045419 A/G cg11822372 chr1:151115635 SEMA6C 0.54 8.2 0.41 5.39e-15 Childhood ear infection; LUSC cis rs9900062 0.586 rs12600679 chr17:62687327 T/G cg02598441 chr17:62777298 LOC146880 -0.54 -6.87 -0.35 3.17e-11 QT interval; LUSC trans rs12543645 0.598 rs35338507 chr8:10277982 G/A cg15556689 chr8:8085844 FLJ10661 0.46 6.25 0.32 1.27e-9 Schizophrenia; LUSC cis rs10887741 0.690 rs11202503 chr10:89440749 T/G cg13926569 chr10:89418898 PAPSS2 0.34 7.32 0.37 1.86e-12 Exercise (leisure time); LUSC cis rs4601821 0.858 rs2298489 chr11:113235419 C/T cg14159747 chr11:113255604 NA -0.29 -6.81 -0.35 4.53e-11 Alcoholic chronic pancreatitis; LUSC cis rs2346177 0.542 rs6718875 chr2:46687982 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.58 -9.0 -0.44 1.75e-17 HDL cholesterol; LUSC cis rs9303401 0.659 rs17822837 chr17:56737838 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.84 13.42 0.59 3.99e-33 Cognitive test performance; LUSC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.515 rs13142498 chr4:98792443 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.0 0.44 1.76e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs2262909 0.962 rs17459246 chr19:22278121 T/C cg05197062 chr11:11642011 GALNTL4 0.54 7.58 0.38 3.39e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.75 0.6 2.12e-34 Platelet count; LUSC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.37 5.66 0.3 3.23e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs2652834 1.000 rs2652838 chr15:63396088 A/G cg05507819 chr15:63340323 TPM1 0.67 8.2 0.41 5.33e-15 HDL cholesterol; LUSC cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg24562669 chr7:97807699 LMTK2 0.39 6.73 0.35 7.47e-11 Breast cancer; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg04025307 chr7:1156635 C7orf50 0.41 6.31 0.33 8.96e-10 Longevity;Endometriosis; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg20849893 chr7:64541193 NA -0.48 -7.08 -0.36 8.65e-12 Calcium levels; LUSC cis rs7089973 0.604 rs11196932 chr10:116584386 C/T cg23260525 chr10:116636907 FAM160B1 0.43 9.16 0.45 5.47e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs637571 0.544 rs617791 chr11:65702523 C/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.44 6.42 0.33 4.74e-10 Eosinophil percentage of white cells; LUSC cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs9395066 0.545 rs3799979 chr6:44845514 A/G cg25276700 chr6:44698697 NA 0.3 5.96 0.31 6.31e-9 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14878842 chr13:113730426 MCF2L 0.43 6.23 0.32 1.41e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg16535667 chr11:65410126 SIPA1 -0.44 -6.09 -0.32 3.05e-9 Blood pressure (age interaction); LUSC cis rs6121246 0.909 rs6089058 chr20:30326338 T/G cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC cis rs4237845 0.537 rs9645819 chr12:58270063 T/C cg00677455 chr12:58241039 CTDSP2 0.71 11.06 0.52 1.99e-24 Intelligence (multi-trait analysis); LUSC trans rs5756813 1.000 rs5756813 chr22:38175477 A/C cg19894588 chr14:64061835 NA -0.52 -7.83 -0.39 6.34e-14 Optic cup area;Vertical cup-disc ratio; LUSC cis rs4555082 1.000 rs7146012 chr14:105757566 G/A cg13114125 chr14:105738426 BRF1 -0.85 -14.23 -0.61 3.06e-36 Mean platelet volume;Platelet distribution width; LUSC cis rs10193935 0.901 rs13393459 chr2:42463124 C/T cg27598129 chr2:42591480 NA -0.59 -7.88 -0.4 4.82e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg25767906 chr1:53392781 SCP2 -0.51 -9.09 -0.45 9.24e-18 Monocyte count; LUSC cis rs11971779 0.616 rs6974907 chr7:139068729 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9302635 0.513 rs13334151 chr16:72189727 A/C cg01557791 chr16:72042693 DHODH -0.5 -6.48 -0.33 3.3e-10 Blood protein levels; LUSC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg15556689 chr8:8085844 FLJ10661 0.89 15.92 0.66 7.25e-43 Neuroticism; LUSC cis rs2445762 0.600 rs12148492 chr15:51653193 A/C cg07517944 chr15:51633816 GLDN -0.4 -6.41 -0.33 4.98e-10 Hormone measurements; LUSC cis rs6500395 1.000 rs7201196 chr16:48674030 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.86e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9457247 0.534 rs12055488 chr6:167379570 A/G cg23791538 chr6:167370224 RNASET2 0.52 8.67 0.43 1.87e-16 Crohn's disease; LUSC trans rs225245 0.791 rs7216391 chr17:34024706 G/A cg19694781 chr19:47549865 TMEM160 -0.39 -6.2 -0.32 1.66e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.97 -0.44 2.14e-17 Monocyte percentage of white cells; LUSC cis rs1808579 0.935 rs2435307 chr18:21127910 A/G cg14672496 chr18:21087552 C18orf8 -0.33 -5.74 -0.3 2.17e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04074137 chr3:142720408 SR140 -0.41 -5.97 -0.31 6.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg04944784 chr2:26401820 FAM59B -0.73 -10.7 -0.51 3.55e-23 Gut microbiome composition (summer); LUSC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg03709012 chr19:19516395 GATAD2A -0.77 -11.95 -0.55 1.19e-27 Tonsillectomy; LUSC trans rs1493916 0.837 rs2123333 chr18:31410730 G/A cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs1775715 0.870 rs3847415 chr10:32219456 G/T cg18675610 chr10:32216311 ARHGAP12 0.28 6.18 0.32 1.92e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.79 0.54 4.46e-27 Personality dimensions; LUSC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg14582100 chr15:45693742 SPATA5L1 0.56 10.5 0.5 1.84e-22 Homoarginine levels; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg23131131 chr22:24373011 LOC391322 -0.39 -5.71 -0.3 2.56e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg18758796 chr5:131593413 PDLIM4 0.33 5.66 0.3 3.18e-8 Blood metabolite levels; LUSC cis rs72781680 0.716 rs2551326 chr2:23982378 T/C cg08917208 chr2:24149416 ATAD2B 0.58 6.49 0.33 3.15e-10 Lymphocyte counts; LUSC cis rs67366981 0.720 rs4447349 chr14:77685381 G/A cg22824376 chr14:77648248 TMEM63C 0.88 8.54 0.42 4.76e-16 Obsessive-compulsive symptoms; LUSC trans rs2624839 0.704 rs2624838 chr3:50205642 C/G cg21659725 chr3:3221576 CRBN 0.42 6.17 0.32 2.02e-9 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg26380479 chr7:97908229 NA -0.27 -5.9 -0.31 8.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.77 -13.52 -0.59 1.62e-33 Total body bone mineral density; LUSC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg11812906 chr14:75593930 NEK9 -0.63 -10.39 -0.49 4.13e-22 Height; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg17178900 chr1:205818956 PM20D1 0.68 10.96 0.51 4.42e-24 Menarche (age at onset); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15611150 chr3:133524362 SRPRB 0.38 6.09 0.32 3.11e-9 Asthma; LUSC cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.03 0.52 2.51e-24 Colorectal cancer; LUSC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.37 0.49 5.04e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg00343986 chr7:65444356 GUSB 0.43 6.54 0.34 2.26e-10 Aortic root size; LUSC cis rs2109514 0.902 rs28495552 chr7:116113744 C/G cg12739419 chr7:116140593 CAV2 -0.27 -5.92 -0.31 7.84e-9 Prevalent atrial fibrillation; LUSC trans rs6952808 0.756 rs4719311 chr7:1881813 C/T cg11244813 chr1:145039882 PDE4DIP 0.37 6.11 0.32 2.76e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg21724239 chr8:58056113 NA 0.86 9.61 0.47 1.83e-19 Developmental language disorder (linguistic errors); LUSC cis rs10876993 0.890 rs4760165 chr12:58063801 C/T cg18357645 chr12:58087776 OS9 0.54 8.28 0.41 2.96e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs425277 1.000 rs262647 chr1:2095699 C/T cg24578937 chr1:2090814 PRKCZ 0.6 13.87 0.6 7.29e-35 Height; LUSC cis rs11105298 0.891 rs11105325 chr12:89938590 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.21 -0.37 3.65e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs35883536 0.626 rs12135243 chr1:101092955 G/A cg06223162 chr1:101003688 GPR88 -0.41 -7.26 -0.37 2.69e-12 Monocyte count; LUSC cis rs55665837 1.000 rs12287715 chr11:14444575 G/A cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs7267979 0.932 rs449703 chr20:25458559 C/T cg08601574 chr20:25228251 PYGB 0.41 6.25 0.32 1.22e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9549367 0.826 rs9549710 chr13:113898064 A/C cg18105134 chr13:113819100 PROZ -0.66 -9.41 -0.46 8.54e-19 Platelet distribution width; LUSC trans rs7824557 0.564 rs13274106 chr8:11233958 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.37 -0.33 6.16e-10 Retinal vascular caliber; LUSC cis rs9815354 0.812 rs73069240 chr3:41950973 A/T cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6977660 0.943 rs10274447 chr7:19850640 C/T cg05791153 chr7:19748676 TWISTNB 0.52 5.97 0.31 6.23e-9 Thyroid stimulating hormone; LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs61931739 0.533 rs7970871 chr12:33917301 G/A cg06521331 chr12:34319734 NA -0.4 -6.68 -0.34 9.84e-11 Morning vs. evening chronotype; LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.48 0.65 4.01e-41 Platelet count; LUSC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg20476274 chr7:133979776 SLC35B4 0.81 14.06 0.61 1.36e-35 Mean platelet volume; LUSC cis rs11785400 0.793 rs7007891 chr8:143749228 C/T cg10596483 chr8:143751796 JRK -0.52 -7.47 -0.38 7.09e-13 Schizophrenia; LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24143933 chr1:212458162 PPP2R5A 0.44 6.8 0.35 4.83e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg04362960 chr10:104952993 NT5C2 0.49 6.27 0.32 1.11e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg08917208 chr2:24149416 ATAD2B 0.53 5.88 0.31 1e-8 Lymphocyte counts; LUSC cis rs17401966 0.838 rs4846212 chr1:10370312 T/C cg19773385 chr1:10388646 KIF1B -0.5 -8.47 -0.42 7.84e-16 Hepatocellular carcinoma; LUSC cis rs7582180 1.000 rs7582180 chr2:100912463 C/T cg08017756 chr2:100939284 LONRF2 0.38 6.34 0.33 7.61e-10 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.644 rs3986377 chr4:120260270 G/A cg24375607 chr4:120327624 NA 0.71 11.34 0.53 1.94e-25 Corneal astigmatism; LUSC trans rs877282 0.583 rs11253441 chr10:828288 C/T cg22713356 chr15:30763199 NA -0.78 -10.37 -0.49 5.07e-22 Uric acid levels; LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs7119167 0.686 rs6592519 chr11:73045074 T/C cg17517138 chr11:73019481 ARHGEF17 0.49 5.71 0.3 2.49e-8 Blood protein levels; LUSC cis rs9653442 0.704 rs10211595 chr2:100726476 G/C cg22139774 chr2:100720529 AFF3 -0.52 -8.97 -0.44 2.16e-17 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7020830 0.861 rs2291589 chr9:37079661 T/G cg14294708 chr9:37120828 ZCCHC7 1.1 24.44 0.8 2.23e-76 Schizophrenia; LUSC cis rs5769707 0.521 rs6009805 chr22:50058715 T/C cg05373962 chr22:49881684 NA -0.4 -8.46 -0.42 8.69e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11690935 0.731 rs10930491 chr2:172569824 A/G cg13550731 chr2:172543902 DYNC1I2 0.59 9.36 0.46 1.23e-18 Schizophrenia; LUSC cis rs7615316 0.779 rs4434160 chr3:142004728 A/G cg16271453 chr3:142027066 XRN1 -0.4 -7.07 -0.36 8.91e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9549260 0.755 rs2151785 chr13:41243660 G/A cg21288729 chr13:41239152 FOXO1 0.63 9.8 0.47 4.19e-20 Red blood cell count; LUSC cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.56 -0.34 2.08e-10 Monocyte percentage of white cells; LUSC trans rs9329221 0.710 rs11779205 chr8:10260100 C/T cg15556689 chr8:8085844 FLJ10661 0.57 7.89 0.4 4.33e-14 Neuroticism; LUSC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg24110177 chr3:50126178 RBM5 0.55 9.0 0.44 1.77e-17 Intelligence (multi-trait analysis); LUSC cis rs983392 0.709 rs7939882 chr11:59973929 A/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.88 -0.31 9.77e-9 Alzheimer's disease (late onset); LUSC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg12463550 chr7:65579703 CRCP 0.57 8.52 0.42 5.72e-16 Aortic root size; LUSC cis rs68092024 0.731 rs793480 chr3:99488364 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -7.02 -0.36 1.28e-11 Cleft lip with or without cleft palate; LUSC cis rs6733011 0.500 rs7560696 chr2:99405800 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.54 -7.09 -0.36 7.93e-12 Bipolar disorder; LUSC cis rs500891 0.868 rs34941468 chr6:84139871 A/T cg08257003 chr6:84140564 ME1 0.35 7.21 0.37 3.81e-12 Platelet-derived growth factor BB levels; LUSC cis rs3099143 1.000 rs3106380 chr15:77104377 G/A cg21673338 chr15:77095150 SCAPER -0.78 -7.47 -0.38 7.09e-13 Recalcitrant atopic dermatitis; LUSC cis rs4954585 0.708 rs6430612 chr2:137006198 C/T cg05194412 chr2:137003533 NA 0.38 7.03 0.36 1.17e-11 Colorectal cancer; LUSC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg00359181 chr2:38893519 GALM -0.52 -6.02 -0.31 4.52e-9 5-HTT brain serotonin transporter levels; LUSC trans rs941408 0.928 rs2260414 chr19:2796316 G/A cg19676328 chr12:49525230 TUBA1B -0.53 -8.36 -0.42 1.7e-15 Total cholesterol levels; LUSC cis rs4409675 0.576 rs7356 chr1:28218100 T/C cg23691781 chr1:28212827 C1orf38 0.32 7.79 0.39 8.33e-14 Corneal astigmatism; LUSC cis rs3806843 0.966 rs11958868 chr5:140201420 T/C cg19875535 chr5:140030758 IK 0.46 7.32 0.37 1.91e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs4654899 0.865 rs10916951 chr1:21528835 A/G cg01072550 chr1:21505969 NA 0.53 8.1 0.41 1.02e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6121246 0.821 rs6121209 chr20:30311258 G/C cg18721089 chr20:30220636 NA -0.34 -5.81 -0.3 1.46e-8 Mean corpuscular hemoglobin; LUSC cis rs11168618 1.000 rs11168637 chr12:48953504 G/A cg24011408 chr12:48396354 COL2A1 0.41 6.45 0.33 4e-10 Adiponectin levels; LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg06001716 chr17:41278141 BRCA1;NBR2 -0.42 -6.6 -0.34 1.61e-10 Menopause (age at onset); LUSC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg23625390 chr15:77176239 SCAPER 0.48 7.29 0.37 2.33e-12 Blood metabolite levels; LUSC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg04287289 chr16:89883240 FANCA 0.78 13.7 0.6 3.2e-34 Vitiligo; LUSC cis rs7804356 1.000 rs3823933 chr7:26853966 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2637266 0.967 rs4608018 chr10:78376110 T/C cg18941641 chr10:78392320 NA 0.38 6.94 0.36 2.04e-11 Pulmonary function; LUSC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg12560992 chr17:57184187 TRIM37 -0.84 -15.24 -0.64 3.5e-40 Intelligence (multi-trait analysis); LUSC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg03517284 chr6:25882590 NA -0.89 -17.75 -0.7 4.1e-50 Urate levels; LUSC cis rs3749237 0.964 rs11714957 chr3:49776178 C/T cg03060546 chr3:49711283 APEH 0.59 8.08 0.4 1.2e-14 Resting heart rate; LUSC cis rs10751667 0.666 rs12295141 chr11:947065 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.39 0.33 5.67e-10 Alzheimer's disease (late onset); LUSC cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg03684893 chr10:554711 DIP2C -0.38 -6.91 -0.35 2.42e-11 Psychosis in Alzheimer's disease; LUSC trans rs3960554 0.709 rs73138006 chr7:75769990 T/C cg19862616 chr7:65841803 NCRNA00174 0.9 10.19 0.49 2.1e-21 Eotaxin levels; LUSC cis rs60843830 0.508 rs300750 chr2:208794 T/G cg21211680 chr2:198530 NA 0.35 5.77 0.3 1.85e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4499344 0.633 rs259246 chr19:33146154 G/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.75 11.4 0.53 1.16e-25 Mean platelet volume; LUSC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg17143192 chr8:8559678 CLDN23 0.37 5.76 0.3 1.89e-8 Mood instability; LUSC cis rs7255045 0.742 rs7251196 chr19:12950863 C/T cg21491176 chr19:12958399 MAST1 -0.34 -5.8 -0.3 1.5e-8 Mean corpuscular volume; LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg22920501 chr2:26401640 FAM59B -0.8 -11.67 -0.54 1.27e-26 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.54 -8.53 -0.42 5.32e-16 Prudent dietary pattern; LUSC trans rs2243480 1.000 rs34974928 chr7:65364006 T/C cg10756647 chr7:56101905 PSPH 0.87 8.39 0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs16937 0.711 rs10900467 chr1:205160074 G/A cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs1018836 0.923 rs13255452 chr8:91582988 A/G cg16814680 chr8:91681699 NA -0.75 -12.1 -0.55 3.37e-28 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg23711669 chr6:146136114 FBXO30 0.74 13.25 0.59 1.76e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg12463550 chr7:65579703 CRCP -0.41 -5.98 -0.31 5.79e-9 Aortic root size; LUSC cis rs3741151 1.000 rs74346863 chr11:73054772 C/T cg17517138 chr11:73019481 ARHGEF17 1.04 8.68 0.43 1.78e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7267979 0.932 rs6138600 chr20:25521346 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.82 0.7 2.19e-50 Liver enzyme levels (alkaline phosphatase); LUSC trans rs800082 0.647 rs6791653 chr3:144177094 T/G cg24215973 chr2:240111563 HDAC4 0.41 6.1 0.32 2.96e-9 Smoking behavior; LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg02475777 chr4:1388615 CRIPAK -0.47 -7.09 -0.36 7.98e-12 Obesity-related traits; LUSC cis rs61931739 0.500 rs10772160 chr12:34456848 G/A cg06521331 chr12:34319734 NA -0.41 -6.75 -0.35 6.42e-11 Morning vs. evening chronotype; LUSC trans rs895636 0.898 rs10205310 chr2:45188646 A/G cg19444027 chr12:57145625 PRIM1 0.53 6.31 0.33 8.83e-10 Metabolite levels;Fasting plasma glucose; LUSC cis rs13385 0.769 rs34266577 chr5:139547797 C/T cg26211634 chr5:139558579 C5orf32 0.45 6.3 0.33 9.46e-10 Atrial fibrillation; LUSC cis rs57549656 0.799 rs2110120 chr19:2711413 A/G cg06609049 chr19:2785107 THOP1 0.47 6.21 0.32 1.62e-9 Schizophrenia; LUSC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg04518342 chr5:131593106 PDLIM4 0.45 8.34 0.42 1.91e-15 Breast cancer; LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.88 0.66 1.08e-42 Platelet count; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg01125463 chr6:42946178 PEX6 -0.37 -6.01 -0.31 4.78e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.84 -0.3 1.26e-8 Vitiligo; LUSC cis rs1577917 0.917 rs1414201 chr6:86500316 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.72 -0.35 7.73e-11 Response to antipsychotic treatment; LUSC cis rs75804782 0.641 rs3769124 chr2:239349362 G/A cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg17554472 chr22:41940697 POLR3H -0.48 -5.77 -0.3 1.85e-8 Vitiligo; LUSC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg06634786 chr22:41940651 POLR3H -0.52 -6.14 -0.32 2.33e-9 Crohn's disease;Inflammatory bowel disease; LUSC trans rs637571 0.528 rs566266 chr11:65573587 A/C cg17712092 chr4:129076599 LARP1B -0.71 -10.28 -0.49 1.02e-21 Eosinophil percentage of white cells; LUSC cis rs56283067 0.578 rs72862930 chr6:45361883 C/T cg18551225 chr6:44695536 NA -0.42 -6.35 -0.33 6.91e-10 Total body bone mineral density; LUSC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.11 -0.41 9.95e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1775715 0.737 rs2799017 chr10:32203460 A/G cg18675610 chr10:32216311 ARHGAP12 0.31 6.67 0.34 1.07e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs477692 1.000 rs477692 chr10:131426022 T/C cg11019008 chr10:131425282 MGMT 0.42 6.31 0.33 8.88e-10 Response to temozolomide; LUSC cis rs3125734 0.633 rs3902162 chr10:64041817 C/T cg19640130 chr10:64028056 RTKN2 -0.4 -7.02 -0.36 1.25e-11 Rheumatoid arthritis; LUSC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg25809561 chr17:30822961 MYO1D 0.57 9.8 0.47 4.2e-20 Schizophrenia; LUSC cis rs2290416 0.892 rs59742520 chr8:144676234 G/C cg08017634 chr8:144659831 NAPRT1 0.73 6.16 0.32 2.15e-9 Attention deficit hyperactivity disorder; LUSC cis rs9326248 1.000 rs7946257 chr11:117053165 A/G cg26566898 chr11:117069891 TAGLN 0.48 8.42 0.42 1.15e-15 Blood protein levels; LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs2625529 0.730 rs2957368 chr15:72329906 C/T cg16672083 chr15:72433130 SENP8 -0.48 -7.82 -0.39 7.02e-14 Red blood cell count; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.57 -8.86 -0.44 5e-17 Lymphocyte counts; LUSC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg05855489 chr10:104503620 C10orf26 0.58 9.3 0.45 1.84e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg13939156 chr17:80058883 NA 0.33 6.43 0.33 4.45e-10 Life satisfaction; LUSC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs8017423 0.967 rs2277516 chr14:90722824 G/C cg04374321 chr14:90722782 PSMC1 0.75 12.08 0.55 4e-28 Mortality in heart failure; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg15383120 chr6:291909 DUSP22 -0.46 -7.12 -0.36 6.57e-12 Menopause (age at onset); LUSC cis rs12532214 0.690 rs74446924 chr7:3127245 C/T cg19214707 chr7:3157722 NA -0.42 -6.08 -0.32 3.3e-9 Itch intensity from mosquito bite; LUSC trans rs656319 0.605 rs60278284 chr8:10003210 G/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.23 -0.37 3.3e-12 Myopia (pathological); LUSC cis rs2019216 0.500 rs7210996 chr17:21917331 G/A cg22648282 chr17:21454238 C17orf51 -0.51 -7.54 -0.38 4.43e-13 Pelvic organ prolapse; LUSC cis rs3768617 0.966 rs10911253 chr1:183086190 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.74 0.43 1.16e-16 Fuchs's corneal dystrophy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08644993 chr1:153508755 S100A6 -0.38 -6.06 -0.31 3.66e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.7e-19 Menopause (age at onset); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg15109118 chr6:5431669 FARS2 0.48 7.05 0.36 1.03e-11 Neuroticism; LUSC cis rs7267979 0.844 rs6107027 chr20:25288632 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 16.67 0.67 7.97e-46 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9329221 0.527 rs34259385 chr8:10325456 C/T cg27411982 chr8:10470053 RP1L1 -0.47 -7.22 -0.37 3.63e-12 Neuroticism; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg08472276 chr7:1133186 C7orf50;GPER -0.4 -6.46 -0.33 3.78e-10 Longevity;Endometriosis; LUSC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg14784868 chr12:69753453 YEATS4 0.63 9.25 0.45 2.82e-18 Blood protein levels; LUSC trans rs941408 0.515 rs1640265 chr19:2784405 C/T cg22153745 chr1:153894579 GATAD2B -0.53 -7.33 -0.37 1.77e-12 Total cholesterol levels; LUSC cis rs478304 0.593 rs7120713 chr11:65483374 G/C cg05805236 chr11:65401703 PCNXL3 -0.64 -10.46 -0.5 2.47e-22 Acne (severe); LUSC cis rs1808579 1.000 rs891386 chr18:21103971 A/C cg14672496 chr18:21087552 C18orf8 0.34 5.77 0.3 1.8e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs55665837 0.524 rs2882128 chr11:14414634 A/C cg05501817 chr11:14380813 RRAS2 -0.47 -7.41 -0.38 1.05e-12 Vitamin D levels; LUSC cis rs3947 0.855 rs1293327 chr8:11694986 G/A cg00262122 chr8:11665843 FDFT1 -0.53 -6.55 -0.34 2.19e-10 Blood protein levels; LUSC cis rs3540 0.960 rs28539372 chr15:91021412 T/A cg10434728 chr15:90938212 IQGAP1 0.32 5.71 0.3 2.53e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg22963979 chr7:1858916 MAD1L1 -0.47 -6.84 -0.35 3.75e-11 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02285715 chr20:61493179 TCFL5 -0.41 -6.01 -0.31 4.74e-9 Electrocardiographic conduction measures; LUSC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.16 -0.32 2.13e-9 Life satisfaction; LUSC cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg21535247 chr6:8435926 SLC35B3 0.6 9.27 0.45 2.37e-18 Motion sickness; LUSC cis rs3820068 0.608 rs12091644 chr1:16044945 G/A cg24675056 chr1:15929824 NA 0.43 6.95 0.36 1.94e-11 Systolic blood pressure; LUSC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg01879757 chr17:41196368 BRCA1 -0.5 -8.05 -0.4 1.48e-14 Menopause (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04246999 chr16:71930048 KIAA0174 0.73 5.96 0.31 6.48e-9 Cognitive performance; LUSC cis rs524023 0.914 rs11231845 chr11:64407419 G/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.48 -0.5 2.05e-22 Urate levels in obese individuals; LUSC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg17366294 chr4:99064904 C4orf37 0.58 10.39 0.49 4.16e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg10150615 chr22:24372951 LOC391322 -0.41 -6.75 -0.35 6.46e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg26384229 chr12:38710491 ALG10B 0.92 15.67 0.65 7.13e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs9443645 0.527 rs36128361 chr6:79684340 C/G cg23262351 chr6:79576851 IRAK1BP1 -0.39 -5.95 -0.31 6.72e-9 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg12963246 chr6:28129442 ZNF389 0.4 5.96 0.31 6.46e-9 Parkinson's disease; LUSC cis rs10791097 0.568 rs4411284 chr11:130738568 A/C cg12179176 chr11:130786555 SNX19 0.84 14.71 0.63 4.12e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9527 0.568 rs1926036 chr10:104883812 C/T cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg08807101 chr21:30365312 RNF160 -0.76 -13.45 -0.59 2.85e-33 Dental caries; LUSC cis rs16917546 0.967 rs10995246 chr10:64391846 C/A cg03961010 chr10:64397487 ZNF365 -0.43 -6.71 -0.34 8.44e-11 Basal cell carcinoma; LUSC cis rs10832963 0.961 rs10832954 chr11:18643559 G/A cg20219074 chr11:18656078 SPTY2D1 0.72 10.87 0.51 9.28e-24 Breast cancer; LUSC cis rs9928842 0.882 rs4737 chr16:75238103 A/G cg09066997 chr16:75300724 BCAR1 -0.5 -6.07 -0.32 3.47e-9 Alcoholic chronic pancreatitis; LUSC cis rs79911532 0.515 rs77381667 chr7:75663126 C/T cg03592824 chr7:75666768 STYXL1 0.7 6.83 0.35 4.03e-11 Mononucleosis; LUSC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg26897989 chr16:1907736 C16orf73 -0.42 -6.63 -0.34 1.37e-10 Glomerular filtration rate in chronic kidney disease; LUSC trans rs877282 0.898 rs11253341 chr10:765008 G/C cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs4555082 0.874 rs28785556 chr14:105745388 A/T cg27165867 chr14:105738592 BRF1 -0.51 -7.14 -0.36 6.02e-12 Mean platelet volume;Platelet distribution width; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02902800 chr4:6784175 KIAA0232 -0.45 -6.02 -0.31 4.48e-9 Bipolar disorder and schizophrenia; LUSC cis rs9467773 1.000 rs9393732 chr6:26530898 G/A cg05738196 chr6:26577821 NA 0.82 15.81 0.65 1.93e-42 Intelligence (multi-trait analysis); LUSC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg07061783 chr6:25882402 NA 0.43 6.06 0.31 3.6e-9 Blood metabolite levels; LUSC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg22875332 chr1:76189707 ACADM 0.83 13.77 0.6 1.8e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7106204 0.668 rs7119362 chr11:24218132 G/T ch.11.24196551F chr11:24239977 NA 1.13 14.35 0.62 9.89e-37 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11190604 1.000 rs2489049 chr10:102350732 G/A cg16342193 chr10:102329863 NA -0.33 -6.1 -0.32 2.86e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs28785552 0.800 rs10853855 chr19:53232293 A/G cg22067481 chr19:53234126 ZNF611 -0.51 -7.02 -0.36 1.23e-11 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs35110281 0.574 rs1836856 chr21:44964638 A/T cg04455712 chr21:45112962 RRP1B 0.47 9.02 0.44 1.47e-17 Mean corpuscular volume; LUSC cis rs4073582 0.595 rs528842 chr11:66032390 G/A cg14036092 chr11:66035641 RAB1B 0.45 6.51 0.34 2.77e-10 Gout; LUSC trans rs208520 0.690 rs4710311 chr6:66823223 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -15.21 -0.64 4.49e-40 Exhaled nitric oxide output; LUSC cis rs34779708 0.966 rs878264 chr10:35440581 T/C cg04310649 chr10:35416472 CREM -0.41 -6.56 -0.34 2.03e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4921915 0.598 rs55686478 chr8:18250375 G/A cg18736775 chr8:18248649 NAT2 -0.56 -6.07 -0.32 3.49e-9 Iron status biomarkers (transferrin levels); LUSC trans rs877282 0.629 rs78997110 chr10:764388 A/G cg22713356 chr15:30763199 NA 1.09 14.2 0.61 4.05e-36 Uric acid levels; LUSC cis rs6500602 0.702 rs11076834 chr16:4549583 C/G cg08645402 chr16:4508243 NA 0.51 8.5 0.42 6.33e-16 Schizophrenia; LUSC trans rs11098499 0.908 rs2017057 chr4:120257711 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.06 0.31 3.61e-9 Corneal astigmatism; LUSC cis rs9309473 0.632 rs7599076 chr2:73585519 G/T cg20560298 chr2:73613845 ALMS1 -0.56 -8.09 -0.4 1.13e-14 Metabolite levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20557037 chr2:165698099 COBLL1 -0.42 -6.55 -0.34 2.22e-10 Triglycerides; LUSC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg09323728 chr8:95962352 TP53INP1 -0.39 -7.73 -0.39 1.25e-13 Type 2 diabetes; LUSC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg08027265 chr7:2291960 NA -0.4 -6.59 -0.34 1.74e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg20476274 chr7:133979776 SLC35B4 0.8 14.2 0.61 3.89e-36 Mean platelet volume; LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg03579872 chr1:53393473 SCP2 -0.39 -5.87 -0.31 1.07e-8 Monocyte count; LUSC trans rs7613875 0.600 rs2247510 chr3:50126215 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.51 8.0 0.4 2.07e-14 Body mass index; LUSC cis rs9303401 0.592 rs66583824 chr17:56639853 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC trans rs9693857 0.520 rs4841163 chr8:9366178 C/G cg27411982 chr8:10470053 RP1L1 0.41 6.26 0.32 1.17e-9 Systolic blood pressure; LUSC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.13 0.55 2.54e-28 Cognitive test performance; LUSC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg02187348 chr16:89574699 SPG7 0.61 9.91 0.48 1.88e-20 Multiple myeloma (IgH translocation); LUSC trans rs1459104 0.866 rs67929427 chr11:54824182 C/T cg15704280 chr7:45808275 SEPT13 0.75 6.55 0.34 2.23e-10 Body mass index; LUSC cis rs9911578 0.967 rs6503890 chr17:57064167 A/G cg12560992 chr17:57184187 TRIM37 0.87 15.71 0.65 5.05e-42 Intelligence (multi-trait analysis); LUSC cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg14844989 chr11:31128820 NA -0.39 -5.99 -0.31 5.29e-9 Red blood cell count; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg05552183 chr6:42928497 GNMT 0.47 7.98 0.4 2.37e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg03354898 chr7:1950403 MAD1L1 -0.33 -6.28 -0.32 1.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg09796270 chr17:17721594 SREBF1 -0.43 -7.55 -0.38 4.32e-13 Total body bone mineral density; LUSC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg20887711 chr4:1340912 KIAA1530 0.44 6.64 0.34 1.28e-10 Obesity-related traits; LUSC cis rs1376877 0.538 rs12474416 chr2:204226003 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.5 6.43 0.33 4.33e-10 Subclinical atherosclerosis traits (other); LUSC trans rs11039798 1.000 rs10838918 chr11:48507449 A/G cg15704280 chr7:45808275 SEPT13 0.74 7.02 0.36 1.22e-11 Axial length; LUSC cis rs1865760 0.566 rs10807006 chr6:26048752 C/A cg16482183 chr6:26056742 HIST1H1C 0.53 7.81 0.39 7.32e-14 Height; LUSC cis rs11025559 0.812 rs11025583 chr11:20513260 C/T cg19653624 chr11:20408972 PRMT3 0.63 8.25 0.41 3.61e-15 Pursuit maintenance gain; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14211646 chr1:26758996 DHDDS 0.41 6.27 0.32 1.1e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg22823121 chr1:150693482 HORMAD1 0.5 7.28 0.37 2.45e-12 Melanoma; LUSC trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg27661571 chr11:113659931 NA -0.52 -6.19 -0.32 1.73e-9 Hip circumference adjusted for BMI; LUSC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg12667521 chr19:29218732 NA 0.58 7.24 0.37 3.04e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg12963246 chr6:28129442 ZNF389 0.53 7.4 0.38 1.11e-12 Depression; LUSC cis rs7582720 1.000 rs72934554 chr2:203987806 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.61 0.43 2.86e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.85 13.66 0.6 4.78e-34 Platelet count; LUSC cis rs7818345 0.967 rs10107416 chr8:19286253 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.35 -6.73 -0.35 7.58e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7572644 0.699 rs6708889 chr2:28107692 C/T cg27432699 chr2:27873401 GPN1 -0.52 -6.86 -0.35 3.4e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg23436779 chr17:56769830 TEX14;RAD51C -0.47 -5.82 -0.3 1.37e-8 Cognitive test performance; LUSC cis rs10887741 0.624 rs9633742 chr10:89432286 A/G cg13926569 chr10:89418898 PAPSS2 0.34 7.35 0.37 1.55e-12 Exercise (leisure time); LUSC cis rs10751667 0.961 rs7396670 chr11:929269 A/G ch.11.42038R chr11:967971 AP2A2 0.53 7.83 0.39 6.49e-14 Alzheimer's disease (late onset); LUSC cis rs6831352 0.819 rs1230158 chr4:99990186 T/C cg12011299 chr4:100065546 ADH4 0.65 10.16 0.49 2.68e-21 Alcohol dependence; LUSC cis rs7568458 0.870 rs1058588 chr2:85808871 A/G cg23752985 chr2:85803571 VAMP8 -0.37 -7.95 -0.4 2.81e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7647973 0.769 rs7434187 chr3:49032967 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.63 9.21 0.45 3.76e-18 Menarche (age at onset); LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.84 0.44 5.72e-17 Prudent dietary pattern; LUSC cis rs7246657 0.941 rs10418729 chr19:37737065 A/C cg23950597 chr19:37808831 NA -0.56 -6.57 -0.34 1.88e-10 Coronary artery calcification; LUSC trans rs61931739 0.890 rs1705748 chr12:34133171 A/G cg26384229 chr12:38710491 ALG10B 0.57 9.05 0.44 1.16e-17 Morning vs. evening chronotype; LUSC cis rs9329221 0.905 rs6601451 chr8:10243681 C/G cg27411982 chr8:10470053 RP1L1 -0.54 -8.98 -0.44 1.95e-17 Neuroticism; LUSC cis rs4654899 0.758 rs7556221 chr1:21455559 C/G cg01072550 chr1:21505969 NA -0.52 -8.01 -0.4 1.87e-14 Superior frontal gyrus grey matter volume; LUSC cis rs10905065 0.861 rs10752069 chr10:5752403 A/G cg11519256 chr10:5708881 ASB13 0.41 5.96 0.31 6.51e-9 Menopause (age at onset); LUSC cis rs1595825 0.732 rs10198804 chr2:198461941 A/C cg00982548 chr2:198649783 BOLL -0.51 -6.46 -0.33 3.65e-10 Ulcerative colitis; LUSC cis rs11122272 0.735 rs2486728 chr1:231535883 T/G cg06096015 chr1:231504339 EGLN1 0.57 10.04 0.48 6.89e-21 Hemoglobin concentration; LUSC cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg22153463 chr1:85462885 MCOLN2 -0.71 -9.59 -0.46 2.18e-19 Serum sulfate level; LUSC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg26314531 chr2:26401878 FAM59B 0.68 7.99 0.4 2.15e-14 Gut microbiome composition (summer); LUSC cis rs6964587 1.000 rs415 chr7:91580490 A/G cg22709100 chr7:91322751 NA -0.41 -5.92 -0.31 7.79e-9 Breast cancer; LUSC cis rs3741151 1.000 rs75114310 chr11:73042047 C/T cg17517138 chr11:73019481 ARHGEF17 1.15 9.74 0.47 7e-20 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg09849774 chr21:43526787 UMODL1;C21orf128 -0.42 -6.2 -0.32 1.69e-9 IgG glycosylation; LUSC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg16240275 chr20:61666158 NCRNA00029 0.41 9.2 0.45 4.06e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.4 5.99 0.31 5.39e-9 Menopause (age at onset); LUSC cis rs12931792 0.712 rs56399904 chr16:30166183 C/T cg17640201 chr16:30407289 ZNF48 0.54 8.51 0.42 5.89e-16 Tonsillectomy; LUSC cis rs66569888 0.789 rs17213078 chr2:106734065 G/A cg16099169 chr2:106886729 NA -0.55 -7.08 -0.36 8.48e-12 Facial morphology (factor 23); LUSC cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs929596 0.564 rs2741028 chr2:234518914 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.37 -0.33 6.31e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs9788682 0.747 rs2568485 chr15:78752114 C/T cg24631222 chr15:78858424 CHRNA5 -0.65 -8.82 -0.43 6.63e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg26384229 chr12:38710491 ALG10B 0.89 15.27 0.64 2.63e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.3 0.37 2.09e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg15704280 chr7:45808275 SEPT13 0.64 7.23 0.37 3.22e-12 Axial length; LUSC cis rs72781680 1.000 rs72788280 chr2:24095907 A/G cg08917208 chr2:24149416 ATAD2B 0.87 10.02 0.48 7.9e-21 Lymphocyte counts; LUSC trans rs7939886 0.920 rs2460212 chr11:55886155 C/T cg15704280 chr7:45808275 SEPT13 -0.73 -6.2 -0.32 1.63e-9 Myopia (pathological); LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg13685833 chr1:53393034 SCP2 0.4 6.09 0.32 3.18e-9 Monocyte count; LUSC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg00599273 chr12:58146742 CDK4 0.31 5.86 0.31 1.14e-8 Multiple sclerosis; LUSC cis rs9549260 0.753 rs61963266 chr13:41171036 G/A cg21288729 chr13:41239152 FOXO1 0.53 5.99 0.31 5.38e-9 Red blood cell count; LUSC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.69 -0.34 9.49e-11 Alzheimer's disease (late onset); LUSC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg07701084 chr6:150067640 NUP43 0.58 9.04 0.44 1.31e-17 Lung cancer; LUSC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg03709012 chr19:19516395 GATAD2A 0.52 6.07 0.32 3.54e-9 Tonsillectomy; LUSC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.46 7.89 0.4 4.26e-14 Breast cancer; LUSC cis rs2046867 0.818 rs11928620 chr3:72863209 A/C cg25664220 chr3:72788482 NA -0.71 -11.91 -0.55 1.7e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs868036 0.958 rs3784709 chr15:68072275 C/T cg05925327 chr15:68127851 NA -0.32 -5.7 -0.3 2.57e-8 Restless legs syndrome; LUSC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.42 6.01 0.31 4.85e-9 Tonsillectomy; LUSC cis rs10752881 1.000 rs8179282 chr1:182974598 C/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.82e-23 Colorectal cancer; LUSC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.46e-11 Tonsillectomy; LUSC cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg05347473 chr6:146136440 FBXO30 0.49 8.22 0.41 4.64e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2797160 0.967 rs2797159 chr6:126009557 G/A cg05901451 chr6:126070800 HEY2 0.57 8.56 0.42 4.25e-16 Endometrial cancer; LUSC cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg22117172 chr7:91764530 CYP51A1 0.32 5.71 0.3 2.51e-8 Breast cancer; LUSC cis rs7707921 0.757 rs226198 chr5:81573992 C/T cg15871215 chr5:81402204 ATG10 0.42 5.93 0.31 7.74e-9 Breast cancer; LUSC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg24154853 chr7:158122151 PTPRN2 0.45 8.72 0.43 1.34e-16 Calcium levels; LUSC cis rs6429082 0.818 rs704714 chr1:235632094 T/C cg26050004 chr1:235667680 B3GALNT2 0.61 8.32 0.41 2.22e-15 Adiposity; LUSC cis rs11229555 0.874 rs10896787 chr11:58285494 G/T cg15696309 chr11:58395628 NA -0.71 -8.88 -0.44 4.11e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg07092213 chr7:1199455 ZFAND2A -0.65 -10.06 -0.48 5.59e-21 Longevity;Endometriosis; LUSC cis rs2109514 0.902 rs926197 chr7:116118330 A/C cg12739419 chr7:116140593 CAV2 0.26 5.76 0.3 1.86e-8 Prevalent atrial fibrillation; LUSC cis rs9399401 0.961 rs9389984 chr6:142652344 C/T cg03128060 chr6:142623767 GPR126 0.32 5.8 0.3 1.56e-8 Chronic obstructive pulmonary disease; LUSC cis rs7202877 0.706 rs1540 chr16:75481185 G/C cg04384234 chr16:75411784 CFDP1 0.68 8.96 0.44 2.36e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.74 -0.51 2.59e-23 Chronic sinus infection; LUSC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg15790184 chr11:494944 RNH1 0.57 6.13 0.32 2.43e-9 Body mass index; LUSC cis rs7954584 0.567 rs11043243 chr12:122356370 G/C cg22618164 chr12:122356400 WDR66 0.63 9.15 0.45 5.7e-18 Mean corpuscular volume; LUSC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.39 -7.85 -0.39 5.8e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg06028605 chr16:24865363 SLC5A11 0.68 9.5 0.46 4.3e-19 Intelligence (multi-trait analysis); LUSC cis rs1881396 0.947 rs8731 chr2:27873326 C/G cg27432699 chr2:27873401 GPN1 0.64 8.61 0.43 3.03e-16 Nonalcoholic fatty liver disease; LUSC cis rs7582180 0.627 rs2099611 chr2:101021090 A/G cg08017756 chr2:100939284 LONRF2 -0.43 -8.29 -0.41 2.76e-15 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg17470723 chr8:74884337 TCEB1 0.52 8.19 0.41 5.44e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4462272 0.503 rs11593131 chr10:101843608 G/A cg02250046 chr10:101825185 CPN1 -0.31 -5.72 -0.3 2.4e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -6.64 -0.34 1.26e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg15252948 chr8:42698594 THAP1 0.5 6.07 0.32 3.41e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7106204 0.609 rs11821417 chr11:24279139 G/T ch.11.24196551F chr11:24239977 NA 0.72 5.97 0.31 6.08e-9 Response to Homoharringtonine (cytotoxicity); LUSC trans rs4689388 0.890 rs4688991 chr4:6302220 C/G cg17567195 chr5:167378696 ODZ2 -0.38 -6.03 -0.31 4.23e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs8060686 0.641 rs73612208 chr16:68206844 G/A cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg25427524 chr10:38739819 LOC399744 -0.72 -13.42 -0.59 3.74e-33 Extrinsic epigenetic age acceleration; LUSC cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg23788917 chr6:8435910 SLC35B3 0.5 7.33 0.37 1.8e-12 Motion sickness; LUSC cis rs9296095 0.632 rs6914422 chr6:33534880 A/G cg14003231 chr6:33640908 ITPR3 -0.39 -6.74 -0.35 6.77e-11 Platelet count; LUSC cis rs7830933 0.780 rs6983481 chr8:23609009 G/T cg04349084 chr8:23602677 NA 0.35 5.7 0.3 2.67e-8 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; LUSC cis rs34638657 0.732 rs11859473 chr16:82201072 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.33 -0.33 7.89e-10 Lung adenocarcinoma; LUSC trans rs2898290 0.593 rs1600252 chr8:11345644 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.58 -0.42 3.56e-16 Systolic blood pressure; LUSC cis rs9463078 0.547 rs1338908 chr6:44728812 C/T cg25276700 chr6:44698697 NA 0.3 6.3 0.33 9.28e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.38 0.33 5.99e-10 Bipolar disorder; LUSC trans rs5756813 0.727 rs4821703 chr22:38136676 C/T cg19894588 chr14:64061835 NA -0.55 -7.3 -0.37 2.1e-12 Optic cup area;Vertical cup-disc ratio; LUSC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg17366294 chr4:99064904 C4orf37 0.47 8.02 0.4 1.79e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.838 rs4785561 chr16:89429052 C/T cg02187348 chr16:89574699 SPG7 0.38 5.73 0.3 2.22e-8 Multiple myeloma (IgH translocation); LUSC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg13770153 chr20:60521292 NA -0.62 -8.39 -0.42 1.36e-15 Body mass index; LUSC cis rs4595586 0.525 rs7972595 chr12:39338000 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.62 0.34 1.46e-10 Morning vs. evening chronotype; LUSC cis rs34779708 0.966 rs35079558 chr10:35479886 A/G cg03585969 chr10:35415529 CREM 0.62 8.98 0.44 2.08e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4253772 0.938 rs11704979 chr22:46632994 G/A cg09491104 chr22:46646882 C22orf40 -0.62 -6.62 -0.34 1.47e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs11229555 1.000 rs2276153 chr11:58407740 C/G cg15696309 chr11:58395628 NA -0.68 -8.92 -0.44 3.06e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6500602 0.702 rs6500605 chr16:4502410 C/T cg08645402 chr16:4508243 NA 0.5 8.56 0.42 4.25e-16 Schizophrenia; LUSC cis rs9462027 0.628 rs6937314 chr6:34799308 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.79 -0.3 1.6e-8 Systemic lupus erythematosus; LUSC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg04362960 chr10:104952993 NT5C2 0.58 8.37 0.42 1.64e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9467773 0.935 rs11752946 chr6:26560364 C/A cg12292205 chr6:26970375 C6orf41 0.38 6.0 0.31 5.08e-9 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.645 rs8181635 chr12:86465136 C/T cg02569458 chr12:86230093 RASSF9 -0.37 -5.88 -0.31 9.77e-9 Major depressive disorder; LUSC cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg04450456 chr4:17643702 FAM184B -0.41 -6.53 -0.34 2.45e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg24692254 chr21:30365293 RNF160 0.92 18.72 0.72 5.7e-54 Dental caries; LUSC cis rs3806843 0.576 rs246024 chr5:140333952 C/T cg19875535 chr5:140030758 IK 0.37 5.67 0.3 3.1e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2625529 0.556 rs1552134 chr15:72232898 T/A cg16672083 chr15:72433130 SENP8 0.49 8.08 0.4 1.21e-14 Red blood cell count; LUSC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11644478 chr21:40555479 PSMG1 0.96 19.19 0.72 7.61e-56 Cognitive function; LUSC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg16447950 chr5:562315 NA -0.59 -7.08 -0.36 8.42e-12 Lung disease severity in cystic fibrosis; LUSC trans rs7980799 1.000 rs7980799 chr12:33576990 A/C cg26384229 chr12:38710491 ALG10B -0.45 -6.48 -0.33 3.29e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs829880 1.000 rs829880 chr12:98845331 G/T cg25150519 chr12:98850993 NA 0.68 10.78 0.51 1.96e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg07701084 chr6:150067640 NUP43 0.56 8.43 0.42 1.07e-15 Lung cancer; LUSC trans rs9929218 1.000 rs12596061 chr16:68807828 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -12.09 -0.55 3.58e-28 Colorectal cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13511387 chr3:11760609 VGLL4 -0.42 -6.18 -0.32 1.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17709503 chr2:99347854 MGAT4A -0.4 -6.02 -0.31 4.51e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs250677 0.687 rs250673 chr5:148445798 C/T cg18129178 chr5:148520854 ABLIM3 -0.69 -10.62 -0.5 6.72e-23 Breast cancer; LUSC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg03929089 chr4:120376271 NA 0.95 15.19 0.64 5.71e-40 Coronary artery disease; LUSC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg06112835 chr11:68658793 MRPL21 0.52 7.93 0.4 3.43e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg07636037 chr3:49044803 WDR6 1.07 17.61 0.69 1.52e-49 Parkinson's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25628257 chr11:61559992 C11orf10;FEN1;MIR611 -0.42 -6.24 -0.32 1.32e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg13206674 chr6:150067644 NUP43 0.6 9.67 0.47 1.13e-19 Lung cancer; LUSC cis rs6669072 0.565 rs10801830 chr1:91272173 G/A cg08895590 chr1:91227319 NA -0.27 -5.81 -0.3 1.48e-8 Cognitive function; LUSC cis rs9911578 0.967 rs2333410 chr17:57137129 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -6.34 -0.33 7.33e-10 Intelligence (multi-trait analysis); LUSC cis rs72781680 1.000 rs56104215 chr2:24133590 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg20790798 chr5:1857306 NA -0.5 -8.58 -0.43 3.6e-16 Cardiovascular disease risk factors; LUSC trans rs7824557 0.564 rs2572386 chr8:11236975 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.76 -0.39 1.05e-13 Retinal vascular caliber; LUSC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg01879757 chr17:41196368 BRCA1 -0.46 -6.97 -0.36 1.72e-11 Menopause (age at onset); LUSC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg15839431 chr19:19639596 YJEFN3 -0.41 -5.68 -0.3 2.93e-8 Tonsillectomy; LUSC cis rs735396 1.000 rs2259816 chr12:121435587 A/C cg02403541 chr12:121454288 C12orf43 -0.61 -8.8 -0.43 7.35e-17 N-glycan levels; LUSC cis rs73206853 0.764 rs56128816 chr12:110775609 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4319547 0.695 rs10846746 chr12:122868696 C/T cg05707623 chr12:122985044 ZCCHC8 0.67 8.16 0.41 6.75e-15 Body mass index; LUSC cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg11584989 chr19:19387371 SF4 0.57 6.88 0.35 2.92e-11 Bipolar disorder; LUSC cis rs1348850 0.554 rs1374438 chr2:178376684 A/G cg22681709 chr2:178499509 PDE11A -0.47 -6.88 -0.35 2.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9398803 0.865 rs1907067 chr6:126837663 A/C cg19875578 chr6:126661172 C6orf173 0.41 6.11 0.32 2.84e-9 Male-pattern baldness; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg27284194 chr4:1044797 NA 0.39 6.3 0.33 9.25e-10 Longevity; LUSC cis rs1030877 0.515 rs2576741 chr2:105897964 T/C cg02079111 chr2:105885981 TGFBRAP1 0.67 9.22 0.45 3.35e-18 Obesity-related traits; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -8.0 -0.4 2.05e-14 Lymphocyte counts; LUSC cis rs739496 0.542 rs7300400 chr12:111792179 A/C cg10833066 chr12:111807467 FAM109A 0.61 11.97 0.55 1.05e-27 Platelet count; LUSC cis rs6692729 0.933 rs2855559 chr1:227080459 G/A cg10327440 chr1:227177885 CDC42BPA -0.5 -7.09 -0.36 7.94e-12 Electrodermal activity; LUSC cis rs950169 0.649 rs12911612 chr15:84691014 T/C cg17507749 chr15:85114479 UBE2QP1 0.56 6.39 0.33 5.58e-10 Schizophrenia; LUSC cis rs9467773 0.526 rs9348710 chr6:26360486 A/C cg05738196 chr6:26577821 NA -0.49 -7.55 -0.38 4.21e-13 Intelligence (multi-trait analysis); LUSC cis rs9653442 0.712 rs6749757 chr2:100730111 A/C cg07810366 chr2:100720526 AFF3 0.44 7.66 0.39 2.04e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg19046167 chr17:80928561 B3GNTL1 0.39 6.39 0.33 5.45e-10 Breast cancer; LUSC cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.86 -0.35 3.32e-11 Monocyte percentage of white cells; LUSC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg04414720 chr1:150670196 GOLPH3L -0.56 -9.04 -0.44 1.33e-17 Tonsillectomy; LUSC cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg00530320 chr1:46809349 NSUN4 0.58 8.51 0.42 5.83e-16 Menopause (age at onset); LUSC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg02223005 chr5:693632 TPPP 0.47 6.19 0.32 1.73e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg06784218 chr1:46089804 CCDC17 -0.47 -8.92 -0.44 3.06e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.36 -0.37 1.46e-12 Personality dimensions; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg16393715 chr7:1948819 MAD1L1 0.35 6.1 0.32 2.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs17376456 0.569 rs7702348 chr5:93065683 A/G cg21475434 chr5:93447410 FAM172A -0.42 -6.01 -0.31 4.92e-9 Diabetic retinopathy; LUSC trans rs4252134 0.801 rs62436702 chr6:161196562 T/C cg15416064 chr12:49209402 NA -0.45 -6.11 -0.32 2.73e-9 Giant cell arteritis; LUSC cis rs8112211 0.911 rs2286475 chr19:38847431 T/C cg14299480 chr19:38876666 GGN -0.35 -5.94 -0.31 7.12e-9 Blood protein levels; LUSC cis rs1003719 0.708 rs3787788 chr21:38502804 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs6840360 0.967 rs6535812 chr4:152599374 C/A cg22705602 chr4:152727874 NA -0.27 -5.7 -0.3 2.66e-8 Intelligence (multi-trait analysis); LUSC cis rs2297440 0.527 rs4809318 chr20:62264760 G/A cg09650180 chr20:62225654 GMEB2 -0.67 -9.67 -0.47 1.12e-19 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs4700695 0.841 rs448454 chr5:65293462 G/A cg21114390 chr5:65439923 SFRS12 0.49 6.03 0.31 4.23e-9 Facial morphology (factor 19); LUSC cis rs427941 0.668 rs201461 chr7:101741625 T/C cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg25428297 chr7:1022841 CYP2W1 0.29 6.24 0.32 1.29e-9 Longevity;Endometriosis; LUSC cis rs9611519 0.929 rs11090039 chr22:41496800 G/A cg03806693 chr22:41940476 POLR3H -0.54 -7.23 -0.37 3.39e-12 Neuroticism; LUSC cis rs9549260 0.755 rs17061491 chr13:41228210 T/A cg21288729 chr13:41239152 FOXO1 0.64 9.95 0.48 1.38e-20 Red blood cell count; LUSC cis rs1395 1.000 rs3769143 chr2:27450724 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.39 -6.45 -0.33 3.89e-10 Blood metabolite levels; LUSC cis rs7264396 0.513 rs3787169 chr20:34419884 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -7.76 -0.39 1.02e-13 Total cholesterol levels; LUSC cis rs17253792 0.822 rs74935793 chr14:56143277 G/A cg01858014 chr14:56050164 KTN1 -0.79 -6.72 -0.35 7.8e-11 Putamen volume; LUSC cis rs12579753 0.879 rs1986537 chr12:82156475 G/C cg07988820 chr12:82153109 PPFIA2 -0.45 -6.67 -0.34 1.04e-10 Resting heart rate; LUSC cis rs2860975 0.967 rs11188134 chr10:96774255 G/C cg09036531 chr10:96991505 NA -0.41 -5.66 -0.3 3.26e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 6.97e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg16928487 chr17:17741425 SREBF1 -0.33 -6.27 -0.32 1.11e-9 Total body bone mineral density; LUSC cis rs1403694 0.655 rs3806688 chr3:186434819 T/C cg12454167 chr3:186435060 KNG1 0.34 8.44 0.42 9.55e-16 Blood protein levels; LUSC cis rs7524258 0.903 rs4908449 chr1:7292700 T/C cg07173049 chr1:7289937 CAMTA1 0.37 7.64 0.39 2.38e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs1997103 1.000 rs4590393 chr7:55408990 C/T cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs983392 0.792 rs525794 chr11:59903287 A/G cg20284999 chr11:59952153 MS4A6A -0.32 -5.66 -0.3 3.3e-8 Alzheimer's disease (late onset); LUSC trans rs561341 1.000 rs530715 chr17:30320544 T/G cg20587970 chr11:113659929 NA -1.16 -15.97 -0.66 4.56e-43 Hip circumference adjusted for BMI; LUSC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg06740227 chr12:86229804 RASSF9 0.43 6.73 0.35 7.2e-11 Major depressive disorder; LUSC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg03452623 chr4:187889614 NA -0.9 -18.4 -0.71 1.04e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg23711669 chr6:146136114 FBXO30 0.73 13.12 0.58 5.29e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs11677416 0.601 rs12469600 chr2:113572357 T/C cg27083787 chr2:113543245 IL1A 0.45 6.52 0.34 2.6e-10 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg20891283 chr12:69753455 YEATS4 0.94 18.17 0.71 8.64e-52 Cerebrospinal fluid biomarker levels; LUSC cis rs6669072 0.565 rs12567901 chr1:91266119 G/A cg08895590 chr1:91227319 NA -0.27 -5.78 -0.3 1.68e-8 Cognitive function; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg07703079 chr11:430292 ANO9 0.64 6.51 0.34 2.78e-10 Body mass index; LUSC cis rs9395066 0.545 rs7749865 chr6:44918406 T/C cg25276700 chr6:44698697 NA 0.3 6.1 0.32 2.88e-9 Height; LUSC cis rs2019216 0.542 rs1987424 chr17:21874036 G/A cg22648282 chr17:21454238 C17orf51 -0.52 -7.68 -0.39 1.8e-13 Pelvic organ prolapse; LUSC cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg23711669 chr6:146136114 FBXO30 0.93 17.83 0.7 1.93e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs1728785 1.000 rs7202306 chr16:68587684 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.29 0.41 2.71e-15 Ulcerative colitis; LUSC trans rs877282 0.853 rs11595507 chr10:756703 C/T cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg06552810 chr11:31128660 NA -0.42 -7.34 -0.37 1.61e-12 Red blood cell count; LUSC cis rs12200560 0.505 rs211175 chr6:97073320 C/T cg06623918 chr6:96969491 KIAA0776 0.51 7.38 0.37 1.26e-12 Coronary heart disease; LUSC cis rs3916 0.688 rs9204 chr12:121177778 A/G cg21892295 chr12:121157589 UNC119B -0.39 -6.49 -0.33 3.02e-10 Urinary metabolites (H-NMR features); LUSC cis rs4423214 0.959 rs11606033 chr11:71154204 A/G cg05163923 chr11:71159392 DHCR7 0.7 10.87 0.51 9.28e-24 Vitamin D levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17660026 chr22:41252631 XPNPEP3;ST13 -0.5 -6.18 -0.32 1.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs9815354 0.812 rs73073234 chr3:42012071 C/T cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.5e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9420 0.961 rs7117205 chr11:57641883 A/G cg23127183 chr11:57508653 C11orf31 -0.53 -7.73 -0.39 1.28e-13 Schizophrenia; LUSC cis rs2239547 0.522 rs6792578 chr3:53004604 G/A cg11645453 chr3:52864694 ITIH4 0.49 11.37 0.53 1.57e-25 Schizophrenia; LUSC cis rs9300255 0.512 rs2851436 chr12:123667354 G/T cg05973401 chr12:123451056 ABCB9 0.52 6.43 0.33 4.36e-10 Neutrophil percentage of white cells; LUSC cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg12011299 chr4:100065546 ADH4 0.61 9.71 0.47 8.65e-20 Alcohol dependence; LUSC cis rs4660306 0.848 rs1088099 chr1:45946654 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 7.04 0.36 1.12e-11 Homocysteine levels; LUSC cis rs3770081 1.000 rs12328085 chr2:86262009 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -0.8 -5.68 -0.3 2.96e-8 Facial emotion recognition (sad faces); LUSC cis rs981844 0.857 rs62325139 chr4:154712213 C/T cg14289246 chr4:154710475 SFRP2 0.48 6.05 0.31 3.9e-9 Response to statins (LDL cholesterol change); LUSC cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg23788917 chr6:8435910 SLC35B3 -0.49 -7.05 -0.36 1.03e-11 Motion sickness; LUSC cis rs6494488 0.500 rs67108203 chr15:65005952 C/T cg08069370 chr15:64387884 SNX1 -0.61 -5.75 -0.3 1.98e-8 Coronary artery disease; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg10802521 chr3:52805072 NEK4 -0.56 -8.94 -0.44 2.71e-17 Bipolar disorder; LUSC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg25456477 chr12:86230367 RASSF9 0.44 7.83 0.39 6.31e-14 Major depressive disorder; LUSC cis rs1506636 1.000 rs615410 chr7:123437765 T/C cg03229431 chr7:123269106 ASB15 0.64 10.43 0.5 3.15e-22 Plateletcrit;Platelet count; LUSC cis rs11098499 0.863 rs1552092 chr4:120488496 C/T cg24375607 chr4:120327624 NA 0.75 11.09 0.52 1.57e-24 Corneal astigmatism; LUSC cis rs6484504 0.600 rs10835763 chr11:31345574 G/A cg06552810 chr11:31128660 NA 0.39 6.87 0.35 3.24e-11 Red blood cell count; LUSC cis rs4144743 1.000 rs2317384 chr17:45329770 G/A cg18085866 chr17:45331354 ITGB3 -0.74 -7.72 -0.39 1.38e-13 Body mass index; LUSC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg21521518 chr4:53727714 RASL11B 0.46 6.1 0.32 2.99e-9 Optic nerve measurement (cup area); LUSC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg11752832 chr7:134001865 SLC35B4 0.56 8.79 0.43 7.94e-17 Mean platelet volume; LUSC trans rs561341 0.941 rs7215147 chr17:30266711 G/A cg27661571 chr11:113659931 NA -0.53 -6.52 -0.34 2.65e-10 Hip circumference adjusted for BMI; LUSC cis rs12594515 1.000 rs12185095 chr15:45994635 G/T cg01629716 chr15:45996671 NA 0.39 5.86 0.31 1.14e-8 Waist circumference;Weight; LUSC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg15744005 chr10:104629667 AS3MT 0.35 7.13 0.36 6.16e-12 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7927592 0.913 rs12272917 chr11:68263370 T/C cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.13e-9 Total body bone mineral density; LUSC cis rs75920871 0.528 rs7484045 chr11:116946890 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.6 -0.34 1.65e-10 Subjective well-being; LUSC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.99 -0.4 2.16e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg01570182 chr17:44337453 NA -0.66 -9.84 -0.47 3.08e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs12900413 0.687 rs12911196 chr15:90310734 G/C cg24249390 chr15:90295951 MESP1 -0.37 -5.85 -0.3 1.17e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs6084875 0.840 rs6052816 chr20:4725086 T/C cg07258627 chr20:4721683 PRNT -0.35 -6.21 -0.32 1.57e-9 Systemic lupus erythematosus; LUSC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.98 0.31 5.65e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10782582 0.593 rs115291524 chr1:76141811 A/G cg10523679 chr1:76189770 ACADM -0.48 -7.0 -0.36 1.42e-11 Daytime sleep phenotypes; LUSC cis rs1559088 0.948 rs10410778 chr19:33592301 C/A cg17764715 chr19:33622953 WDR88 0.6 8.23 0.41 4.15e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg24642439 chr20:33292090 TP53INP2 0.69 10.66 0.5 5.11e-23 Coronary artery disease; LUSC cis rs9517320 0.534 rs912330 chr13:99131294 C/T cg20487152 chr13:99095054 FARP1 -0.41 -6.95 -0.36 1.97e-11 Longevity; LUSC cis rs9916302 0.653 rs11657058 chr17:37699378 T/G cg07936489 chr17:37558343 FBXL20 -0.83 -10.29 -0.49 9.28e-22 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg11764359 chr7:65958608 NA -0.68 -10.33 -0.49 6.65e-22 Aortic root size; LUSC cis rs12908161 1.000 rs36033486 chr15:85319692 A/G cg17173187 chr15:85201210 NMB 0.47 8.9 0.44 3.57e-17 Schizophrenia; LUSC cis rs1801251 0.963 rs66549961 chr2:233602293 A/G cg25237894 chr2:233734115 C2orf82 0.34 6.23 0.32 1.43e-9 Coronary artery disease; LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg16325326 chr1:53192061 ZYG11B -0.76 -12.81 -0.57 7.68e-31 Monocyte count; LUSC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.75 13.5 0.59 1.88e-33 Intelligence (multi-trait analysis); LUSC cis rs9942416 0.601 rs114547168 chr5:74991903 A/G cg19683494 chr5:74908142 NA 0.43 6.65 0.34 1.21e-10 Age-related disease endophenotypes; LUSC cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg18132916 chr6:79620363 NA 0.39 5.91 0.31 8.56e-9 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg06481639 chr22:41940642 POLR3H -0.51 -6.17 -0.32 1.98e-9 Vitiligo; LUSC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg20608306 chr11:116969690 SIK3 0.4 6.74 0.35 7.08e-11 Blood protein levels; LUSC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg15605315 chr1:45957053 TESK2 0.5 8.48 0.42 7.38e-16 High light scatter reticulocyte count; LUSC cis rs7666738 0.579 rs7672718 chr4:98645122 A/G cg17366294 chr4:99064904 C4orf37 0.51 8.12 0.41 9.3e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg20607287 chr7:12443886 VWDE -0.65 -6.48 -0.33 3.37e-10 Coronary artery disease; LUSC cis rs6574644 1.000 rs4903977 chr14:81772095 T/C cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs1775715 0.707 rs2808087 chr10:32146444 C/G cg03015672 chr10:32216066 ARHGAP12 0.35 6.39 0.33 5.5e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs17253792 0.822 rs45501402 chr14:56140115 C/T cg01858014 chr14:56050164 KTN1 -0.79 -6.72 -0.35 7.8e-11 Putamen volume; LUSC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg24296786 chr1:45957014 TESK2 0.47 6.91 0.35 2.51e-11 High light scatter reticulocyte count; LUSC cis rs7119 0.651 rs12902948 chr15:77849254 T/C cg27398640 chr15:77910606 LINGO1 -0.34 -7.06 -0.36 9.97e-12 Type 2 diabetes; LUSC cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.29 0.64 2.16e-40 Morning vs. evening chronotype; LUSC trans rs7243066 0.529 rs1391471 chr18:11297066 A/G cg26633107 chr2:14774086 FAM84A -0.43 -6.07 -0.32 3.49e-9 Dental caries; LUSC cis rs16910800 0.689 rs7128636 chr11:23164689 C/T cg20040320 chr11:23191996 NA -0.6 -7.58 -0.38 3.55e-13 Cancer; LUSC cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg08704250 chr15:31115839 NA -0.45 -6.36 -0.33 6.57e-10 Huntington's disease progression; LUSC cis rs6574644 1.000 rs1957545 chr14:81772981 C/G cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs4642101 0.561 rs7641959 chr3:12810755 G/C cg05775895 chr3:12838266 CAND2 0.49 7.42 0.38 9.85e-13 QRS complex (12-leadsum); LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4363385 0.818 rs1415969 chr1:153006448 G/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.44e-12 Inflammatory skin disease; LUSC cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 8.8e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7267979 1.000 rs8125868 chr20:25324410 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.32 -0.74 2.4e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.39 -7.81 -0.39 7.63e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg07274523 chr3:49395745 GPX1 0.67 10.52 0.5 1.5e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs950776 0.518 rs2869544 chr15:78839400 G/A cg06917634 chr15:78832804 PSMA4 -0.81 -14.25 -0.61 2.54e-36 Sudden cardiac arrest; LUSC cis rs72781680 0.898 rs6712524 chr2:24083925 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.85 0.47 2.88e-20 Lymphocyte counts; LUSC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.86 0.51 1e-23 Schizophrenia; LUSC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg24110177 chr3:50126178 RBM5 -0.61 -10.46 -0.5 2.42e-22 Body mass index; LUSC cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg23158103 chr7:148848205 ZNF398 -0.45 -7.28 -0.37 2.41e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg05084668 chr3:125655381 ALG1L -0.48 -6.79 -0.35 5.06e-11 Blood pressure (smoking interaction); LUSC cis rs7799006 0.895 rs3757437 chr7:2271980 C/T cg12745145 chr7:2261452 MAD1L1 -0.29 -5.76 -0.3 1.88e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs853679 0.517 rs9368554 chr6:28082711 T/C cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg17554472 chr22:41940697 POLR3H 0.49 5.98 0.31 5.86e-9 Vitiligo; LUSC cis rs12410462 0.681 rs113316536 chr1:227547033 T/G cg23173402 chr1:227635558 NA 0.55 6.39 0.33 5.42e-10 Major depressive disorder; LUSC cis rs10740039 0.883 rs1867081 chr10:62386327 A/G cg18175470 chr10:62150864 ANK3 -0.47 -7.0 -0.36 1.42e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg05863683 chr7:1912471 MAD1L1 0.3 5.69 0.3 2.74e-8 Bipolar disorder and schizophrenia; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg11218175 chr11:495084 RNH1 0.53 5.71 0.3 2.51e-8 Body mass index; LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg22868518 chr11:507468 RNH1 -0.64 -5.85 -0.3 1.19e-8 Body mass index; LUSC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg23985595 chr17:80112537 CCDC57 0.31 5.87 0.31 1.08e-8 Life satisfaction; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.62 -0.5 6.83e-23 Alzheimer's disease; LUSC cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg11812906 chr14:75593930 NEK9 0.66 11.37 0.53 1.56e-25 Height; LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs10911363 0.592 rs2702203 chr1:183462513 A/T cg09173681 chr1:183549694 NCF2 0.66 12.24 0.56 1.08e-28 Systemic lupus erythematosus; LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg20295408 chr7:1910781 MAD1L1 -0.49 -7.17 -0.37 4.74e-12 Bipolar disorder and schizophrenia; LUSC cis rs7520050 0.778 rs2991985 chr1:46080530 T/C cg06784218 chr1:46089804 CCDC17 -0.31 -6.17 -0.32 2.02e-9 Red blood cell count;Reticulocyte count; LUSC cis rs11630290 0.639 rs6494442 chr15:64166891 A/G cg12036633 chr15:63758958 NA 0.5 6.06 0.31 3.73e-9 Iris characteristics; LUSC cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg04586622 chr2:25135609 ADCY3 -0.43 -9.2 -0.45 4.07e-18 Body mass index; LUSC cis rs877282 0.853 rs12777155 chr10:754731 G/C cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg03036452 chr22:46663545 TTC38 0.52 5.7 0.3 2.62e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg01416388 chr22:39784598 NA -0.44 -7.31 -0.37 1.97e-12 Intelligence (multi-trait analysis); LUSC cis rs2067615 0.507 rs10746064 chr12:107086245 G/T cg15890332 chr12:107067104 RFX4 0.35 6.13 0.32 2.51e-9 Heart rate; LUSC cis rs983392 0.678 rs1562990 chr11:60023087 C/A cg02771260 chr11:59836817 MS4A3 0.36 5.93 0.31 7.76e-9 Alzheimer's disease (late onset); LUSC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.11 0.32 2.79e-9 Schizophrenia; LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg09877947 chr5:131593287 PDLIM4 0.47 7.31 0.37 2.05e-12 Acylcarnitine levels; LUSC cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs12421382 0.659 rs35093943 chr11:109379872 C/A cg16359550 chr11:109292809 C11orf87 0.35 6.05 0.31 3.96e-9 Schizophrenia; LUSC cis rs13082711 0.911 rs74279676 chr3:27512944 G/A cg02860705 chr3:27208620 NA 0.49 8.2 0.41 5.1e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg24687543 chr11:63912206 MACROD1 0.44 5.87 0.31 1.07e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04125625 chr1:29564120 PTPRU 0.5 7.06 0.36 9.96e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs534126 1.000 rs9918515 chr7:142922662 C/T cg04039957 chr7:143013207 CLCN1 -0.31 -6.0 -0.31 5.15e-9 Cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06064461 chr2:176032401 ATF2;MIR933 0.58 8.3 0.41 2.69e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg03264133 chr6:25882463 NA -0.5 -9.15 -0.45 5.97e-18 Blood metabolite levels; LUSC cis rs7666738 0.546 rs6827131 chr4:98744810 C/G cg05340658 chr4:99064831 C4orf37 0.6 8.9 0.44 3.64e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs10435719 0.867 rs62493601 chr8:11788307 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.11 0.41 9.89e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs897984 0.806 rs8050588 chr16:30937799 G/A cg02466173 chr16:30829666 NA -0.56 -11.18 -0.52 7.23e-25 Dementia with Lewy bodies; LUSC cis rs6580649 0.771 rs1034762 chr12:48389643 G/T cg05342945 chr12:48394962 COL2A1 0.44 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg09491104 chr22:46646882 C22orf40 -0.66 -6.67 -0.34 1.06e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg04455712 chr21:45112962 RRP1B 0.46 8.7 0.43 1.58e-16 Mean corpuscular volume; LUSC cis rs2279817 0.955 rs2270978 chr1:18023365 C/T cg21791023 chr1:18019539 ARHGEF10L 0.52 7.38 0.37 1.27e-12 Neuroticism; LUSC trans rs198712 0.505 rs198319 chr7:24188766 T/C cg06529468 chr19:10676722 KRI1 0.38 6.1 0.32 2.98e-9 Aggressive periodontitis (sex interaction); LUSC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11644478 chr21:40555479 PSMG1 -0.65 -10.05 -0.48 6.28e-21 Menarche (age at onset); LUSC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg23630131 chr7:65973040 NA -0.2 -5.64 -0.3 3.55e-8 Aortic root size; LUSC cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.48 0.33 3.28e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg20243544 chr17:37824526 PNMT 0.52 7.41 0.38 1.02e-12 Asthma; LUSC cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg24642439 chr20:33292090 TP53INP2 0.49 7.42 0.38 9.78e-13 Glomerular filtration rate (creatinine); LUSC cis rs662735 0.515 rs113026 chr11:30846842 G/A cg14844989 chr11:31128820 NA 0.37 5.78 0.3 1.74e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs9393777 0.623 rs3734544 chr6:26468660 G/A cg12826209 chr6:26865740 GUSBL1 0.69 7.67 0.39 1.86e-13 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.621 rs7394681 chr11:952111 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.45 0.33 3.9e-10 Alzheimer's disease (late onset); LUSC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg14583973 chr4:3374767 RGS12 0.38 8.0 0.4 2.01e-14 Serum sulfate level; LUSC cis rs983392 0.803 rs56189574 chr11:59933492 A/G cg20284999 chr11:59952153 MS4A6A -0.36 -6.2 -0.32 1.63e-9 Alzheimer's disease (late onset); LUSC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg20406979 chr6:167373233 NA -0.26 -6.09 -0.32 3.09e-9 Crohn's disease; LUSC cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg24692254 chr21:30365293 RNF160 0.91 18.67 0.71 9.05e-54 Dental caries; LUSC cis rs10419226 0.555 rs3829671 chr19:18777667 T/C cg22001208 chr19:18782374 NA -0.38 -6.33 -0.33 7.77e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs1023500 0.507 rs6002600 chr22:42488906 G/A cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Schizophrenia; LUSC cis rs877282 0.583 rs11253425 chr10:815173 G/A cg13775593 chr10:823151 NA 0.29 5.77 0.3 1.85e-8 Uric acid levels; LUSC cis rs2806561 0.695 rs66592286 chr1:23333649 G/C cg19743168 chr1:23544995 NA 0.39 7.2 0.37 4.01e-12 Height; LUSC cis rs1371867 0.846 rs1788180 chr8:101333368 A/G cg00191853 chr8:101177733 SPAG1 -0.39 -6.47 -0.33 3.49e-10 Atrioventricular conduction; LUSC cis rs12594515 1.000 rs11070467 chr15:45985001 C/T cg19682013 chr15:45996608 NA -0.39 -5.96 -0.31 6.31e-9 Waist circumference;Weight; LUSC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg16447950 chr5:562315 NA -0.52 -6.88 -0.35 3e-11 Obesity-related traits; LUSC trans rs8072100 0.790 rs1962307 chr17:45707871 A/G cg04995722 chr7:26192034 NFE2L3 -0.39 -6.01 -0.31 4.84e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10248839 0.518 rs34011864 chr7:29698499 G/A cg19413766 chr7:29689036 LOC646762 -0.55 -7.41 -0.38 1.07e-12 Facial emotion recognition (angry faces); LUSC cis rs9325144 0.581 rs2730929 chr12:38942739 T/C cg13010199 chr12:38710504 ALG10B -0.55 -8.69 -0.43 1.69e-16 Morning vs. evening chronotype; LUSC cis rs9653442 0.545 rs10496344 chr2:100764125 C/T cg07810366 chr2:100720526 AFF3 0.45 7.72 0.39 1.36e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7584330 0.910 rs880932 chr2:238396963 A/G cg14458575 chr2:238380390 NA 0.72 12.94 0.58 2.6e-31 Prostate cancer; LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.91 -0.35 2.47e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs67366981 0.841 rs55903932 chr14:77706389 T/C cg22824376 chr14:77648248 TMEM63C 0.84 7.56 0.38 3.96e-13 Obsessive-compulsive symptoms; LUSC cis rs11098499 1.000 rs58601355 chr4:120186367 T/C cg24375607 chr4:120327624 NA 0.74 11.0 0.52 3.27e-24 Corneal astigmatism; LUSC cis rs8058578 0.943 rs7197770 chr16:30715908 T/C cg05768032 chr16:30646687 NA 0.4 5.96 0.31 6.32e-9 Multiple myeloma; LUSC cis rs1595825 0.735 rs16827465 chr2:198945680 G/T cg00982548 chr2:198649783 BOLL -0.52 -6.57 -0.34 1.88e-10 Ulcerative colitis; LUSC cis rs35883536 0.513 rs4907910 chr1:101013277 T/A cg09408571 chr1:101003634 GPR88 0.35 6.93 0.35 2.23e-11 Monocyte count; LUSC trans rs9747201 1.000 rs9747201 chr17:80177852 A/C cg07393940 chr7:158741817 NA 0.53 8.39 0.42 1.36e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg07343612 chr16:622815 PIGQ -0.77 -13.2 -0.59 2.57e-32 Height; LUSC cis rs11190604 1.000 rs2489040 chr10:102331298 G/A cg07080220 chr10:102295463 HIF1AN 0.66 9.05 0.44 1.17e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7100689 0.646 rs1340380 chr10:82115619 T/C cg00277334 chr10:82204260 NA -0.52 -7.5 -0.38 5.66e-13 Post bronchodilator FEV1; LUSC cis rs6582630 0.560 rs11504462 chr12:38440379 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.65 -0.34 1.17e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg08027265 chr7:2291960 NA -0.38 -6.25 -0.32 1.29e-9 Bipolar disorder and schizophrenia; LUSC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 13.0 0.58 1.45e-31 Total body bone mineral density; LUSC cis rs11711311 0.955 rs7650764 chr3:113414439 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.37 0.33 6.33e-10 IgG glycosylation; LUSC cis rs4380275 0.931 rs4538239 chr2:774238 C/T cg21665850 chr2:731073 NA 0.42 6.75 0.35 6.49e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg05855489 chr10:104503620 C10orf26 -0.66 -8.34 -0.42 2.01e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs73001065 0.818 rs73004966 chr19:19716558 C/T cg03709012 chr19:19516395 GATAD2A 0.89 7.18 0.37 4.56e-12 LDL cholesterol; LUSC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.65 0.3 3.41e-8 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.42 0.38 9.97e-13 Bipolar disorder; LUSC cis rs7241530 0.662 rs7244039 chr18:75906601 T/C cg14642773 chr18:75888474 NA 0.39 5.96 0.31 6.32e-9 Educational attainment (years of education); LUSC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg23172400 chr8:95962367 TP53INP1 -0.38 -7.69 -0.39 1.64e-13 Type 2 diabetes; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.23e-8 Total body bone mineral density; LUSC cis rs4919694 1.000 rs10509758 chr10:104681710 T/C cg04362960 chr10:104952993 NT5C2 1.1 12.9 0.58 3.57e-31 Arsenic metabolism; LUSC cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.52 0.42 5.7e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303401 0.592 rs12936771 chr17:56725052 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.55e-35 Cognitive test performance; LUSC cis rs2692947 0.702 rs7604842 chr2:96777340 C/T cg23100626 chr2:96804247 ASTL -0.28 -6.58 -0.34 1.82e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg11663144 chr21:46675770 NA -0.42 -7.38 -0.37 1.3e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7647973 0.593 rs1799844 chr3:49847642 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.63 7.33 0.37 1.74e-12 Menarche (age at onset); LUSC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg19912559 chr1:40204330 PPIE 0.53 8.18 0.41 6.17e-15 Blood protein levels; LUSC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg06505273 chr16:24850292 NA 0.4 5.65 0.3 3.43e-8 Intelligence (multi-trait analysis); LUSC cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg12011299 chr4:100065546 ADH4 0.73 12.14 0.55 2.45e-28 Alcohol dependence; LUSC cis rs12891047 0.899 rs11847628 chr14:68284075 G/T cg20999565 chr14:68265668 ZFYVE26 0.37 5.69 0.3 2.82e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11890956 chr21:40555474 PSMG1 1.02 20.37 0.74 1.57e-60 Cognitive function; LUSC cis rs1670533 0.818 rs643484 chr4:1085826 A/G cg27284194 chr4:1044797 NA 0.6 9.03 0.44 1.43e-17 Recombination rate (females); LUSC cis rs11711311 0.955 rs12634241 chr3:113397685 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 5.96 0.31 6.32e-9 IgG glycosylation; LUSC cis rs9473147 0.843 rs6904933 chr6:47628558 G/A cg12968598 chr6:47444699 CD2AP 0.38 5.69 0.3 2.8e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs34891900 0.507 rs2535707 chr22:18181869 C/T cg08824373 chr22:18117835 NA 0.42 6.36 0.33 6.45e-10 Sum neutrophil eosinophil counts; LUSC cis rs73198271 0.960 rs73198287 chr8:8612786 C/T cg01851573 chr8:8652454 MFHAS1 0.59 8.28 0.41 2.93e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg08499158 chr17:42289980 UBTF -0.49 -8.24 -0.41 4.03e-15 Total body bone mineral density; LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg24675658 chr1:53192096 ZYG11B 0.58 9.11 0.45 7.6e-18 Monocyte count; LUSC cis rs977987 0.931 rs1834013 chr16:75496163 G/T cg03315344 chr16:75512273 CHST6 0.57 11.13 0.52 1.07e-24 Dupuytren's disease; LUSC cis rs12210905 0.925 rs12212317 chr6:26986553 G/A cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.98 -0.31 5.84e-9 Hip circumference adjusted for BMI; LUSC cis rs7707921 0.881 rs73134747 chr5:81378294 C/T cg15871215 chr5:81402204 ATG10 -0.43 -6.25 -0.32 1.24e-9 Breast cancer; LUSC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg00990874 chr7:1149470 C7orf50 -0.55 -6.92 -0.35 2.38e-11 Bronchopulmonary dysplasia; LUSC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.58 -0.34 1.86e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs290268 0.838 rs1319677 chr9:93565999 A/G cg02608019 chr9:93564028 SYK 0.54 9.48 0.46 5.07e-19 Platelet count; LUSC cis rs9814567 1.000 rs28409322 chr3:134252385 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11690935 0.959 rs7355594 chr2:172639448 G/T cg13550731 chr2:172543902 DYNC1I2 -0.89 -15.03 -0.64 2.24e-39 Schizophrenia; LUSC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.63 9.65 0.47 1.37e-19 Height; LUSC cis rs34891900 0.507 rs2535679 chr22:18202850 A/G cg19898043 chr22:18121309 BCL2L13 0.38 5.85 0.3 1.19e-8 Sum neutrophil eosinophil counts; LUSC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg19717773 chr7:2847554 GNA12 -0.39 -6.19 -0.32 1.78e-9 Height; LUSC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg22834771 chr12:69754056 YEATS4 -0.54 -8.08 -0.4 1.23e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs9487051 0.773 rs421790 chr6:109543428 T/A cg00509249 chr6:109615579 CCDC162 -0.34 -5.81 -0.3 1.42e-8 Reticulocyte fraction of red cells; LUSC cis rs533581 0.866 rs502258 chr16:88968547 G/A cg16701003 chr16:89028210 CBFA2T3 0.35 6.18 0.32 1.86e-9 Social autistic-like traits; LUSC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg10560079 chr2:191398806 TMEM194B -0.45 -7.45 -0.38 7.79e-13 Pulse pressure; LUSC cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg16584290 chr5:462447 EXOC3 0.45 8.09 0.4 1.09e-14 Cystic fibrosis severity; LUSC cis rs3087591 0.708 rs7505 chr17:29644852 G/A cg24425628 chr17:29625626 OMG;NF1 0.45 6.86 0.35 3.32e-11 Hip circumference; LUSC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg14558114 chr2:88469736 THNSL2 0.8 7.13 0.36 6.19e-12 Plasma clusterin levels; LUSC trans rs2587949 0.615 rs795293 chr3:4185953 C/T cg15139668 chr4:4577005 NA -0.43 -6.2 -0.32 1.68e-9 Periodontitis (DPAL); LUSC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.41 0.33 4.97e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 12.5 0.56 1.09e-29 Hip circumference adjusted for BMI; LUSC trans rs35110281 0.633 rs4818860 chr21:45119617 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.78 0.51 1.86e-23 Mean corpuscular volume; LUSC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg16928487 chr17:17741425 SREBF1 -0.37 -7.11 -0.36 7.27e-12 Total body bone mineral density; LUSC cis rs753778 0.628 rs11579 chr8:142205132 G/A cg18755752 chr8:142205143 DENND3 -0.77 -13.7 -0.6 3.33e-34 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg19077165 chr18:44547161 KATNAL2 0.45 6.68 0.34 9.9e-11 Personality dimensions; LUSC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg13902645 chr11:5959945 NA -0.53 -8.1 -0.41 1.03e-14 DNA methylation (variation); LUSC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg02428538 chr16:24856791 SLC5A11 -0.52 -5.98 -0.31 5.74e-9 Intelligence (multi-trait analysis); LUSC trans rs1994135 0.654 rs1447872 chr12:33718343 C/A cg13010199 chr12:38710504 ALG10B 0.56 7.68 0.39 1.76e-13 Resting heart rate; LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.33 0.67 1.77e-44 Platelet count; LUSC cis rs8044995 0.706 rs73612697 chr16:68162016 G/A cg05110241 chr16:68378359 PRMT7 -0.62 -6.65 -0.34 1.22e-10 Schizophrenia; LUSC cis rs1030877 0.515 rs3828300 chr2:105901107 G/A cg02079111 chr2:105885981 TGFBRAP1 -0.67 -8.08 -0.4 1.22e-14 Obesity-related traits; LUSC cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.81 -0.43 7.2e-17 Monocyte percentage of white cells; LUSC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.49 9.02 0.44 1.56e-17 Total body bone mineral density; LUSC cis rs6977660 0.714 rs10252965 chr7:19822385 A/C cg05791153 chr7:19748676 TWISTNB 0.64 6.74 0.35 6.97e-11 Thyroid stimulating hormone; LUSC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg18357526 chr6:26021779 HIST1H4A 0.37 5.86 0.31 1.09e-8 Intelligence (multi-trait analysis); LUSC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg20790798 chr5:1857306 NA -0.5 -8.7 -0.43 1.52e-16 Cardiovascular disease risk factors; LUSC cis rs921968 0.565 rs6436084 chr2:219639782 A/G cg02176678 chr2:219576539 TTLL4 -0.55 -9.78 -0.47 4.92e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg21132104 chr15:45694354 SPATA5L1 0.57 8.19 0.41 5.77e-15 Homoarginine levels; LUSC cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg11584989 chr19:19387371 SF4 0.68 8.02 0.4 1.86e-14 Bipolar disorder; LUSC cis rs1371867 0.846 rs1788182 chr8:101334620 C/T cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.37e-11 Atrioventricular conduction; LUSC cis rs7914558 0.966 rs10748839 chr10:104953547 A/G cg23093090 chr10:104574429 C10orf26 -0.34 -6.43 -0.33 4.52e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08724901 chr15:89089781 DET1 -0.44 -6.2 -0.32 1.62e-9 Hepatitis; LUSC cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg13010199 chr12:38710504 ALG10B 0.68 10.76 0.51 2.25e-23 Bladder cancer; LUSC cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs2075165 0.901 rs2025577 chr1:156314104 T/C cg20302342 chr1:156215951 PAQR6 0.32 6.17 0.32 1.99e-9 Tonsillectomy; LUSC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg11752832 chr7:134001865 SLC35B4 0.6 9.52 0.46 3.57e-19 Mean platelet volume; LUSC cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg12011299 chr4:100065546 ADH4 0.65 10.82 0.51 1.38e-23 Alcohol dependence; LUSC cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.22 0.56 1.18e-28 Colorectal cancer; LUSC cis rs12893668 0.703 rs12894729 chr14:104035292 G/A cg08213375 chr14:104286397 PPP1R13B 0.38 6.31 0.33 8.61e-10 Reticulocyte count; LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.49 7.33 0.37 1.79e-12 Renal function-related traits (BUN); LUSC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg09085632 chr11:111637200 PPP2R1B -1.03 -16.42 -0.67 8.09e-45 Primary sclerosing cholangitis; LUSC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg04317338 chr11:64019027 PLCB3 0.64 7.33 0.37 1.77e-12 Mean platelet volume; LUSC cis rs11583043 1.000 rs2391573 chr1:101489698 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.88 0.31 9.87e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6964587 1.000 rs4727266 chr7:91570129 C/T cg17063962 chr7:91808500 NA -0.58 -9.19 -0.45 4.34e-18 Breast cancer; LUSC cis rs2692947 0.673 rs2692894 chr2:96784934 T/G cg23100626 chr2:96804247 ASTL -0.3 -7.14 -0.36 6e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg20503657 chr10:835505 NA 1.0 14.01 0.61 2.08e-35 Eosinophil percentage of granulocytes; LUSC cis rs4891159 0.527 rs690593 chr18:74160408 C/G cg24786174 chr18:74118243 ZNF516 0.87 17.23 0.69 4.8e-48 Longevity; LUSC cis rs7759001 0.857 rs4305708 chr6:27372303 T/G cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg27279351 chr12:120934652 DYNLL1 0.63 8.41 0.42 1.21e-15 High light scatter reticulocyte count; LUSC cis rs16854884 0.770 rs6782024 chr3:143816936 G/C cg06585982 chr3:143692056 C3orf58 0.45 6.69 0.34 9.28e-11 Economic and political preferences (feminism/equality); LUSC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg10909506 chr17:38081995 ORMDL3 0.34 6.07 0.32 3.55e-9 Self-reported allergy; LUSC cis rs6964587 0.967 rs10279210 chr7:91616891 G/A cg17063962 chr7:91808500 NA 0.57 9.09 0.45 8.87e-18 Breast cancer; LUSC cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg15997130 chr1:24165203 NA -0.45 -6.62 -0.34 1.42e-10 Immature fraction of reticulocytes; LUSC trans rs1941687 0.831 rs55671114 chr18:31386284 C/A cg27147174 chr7:100797783 AP1S1 -0.45 -6.67 -0.34 1.06e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.44 8.3 0.41 2.61e-15 Autism spectrum disorder or schizophrenia; LUSC cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg13010199 chr12:38710504 ALG10B -0.63 -10.7 -0.51 3.65e-23 Heart rate; LUSC cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg06784218 chr1:46089804 CCDC17 -0.52 -9.78 -0.47 5.14e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2404602 0.647 rs4886837 chr15:77156417 A/G cg23625390 chr15:77176239 SCAPER -0.65 -10.06 -0.48 5.57e-21 Blood metabolite levels; LUSC cis rs7681440 0.647 rs1442136 chr4:90819026 C/T cg15133208 chr4:90757351 SNCA 0.36 6.2 0.32 1.63e-9 Dementia with Lewy bodies; LUSC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg19230755 chr7:65878503 NA -0.41 -5.74 -0.3 2.17e-8 Aortic root size; LUSC cis rs7712401 0.601 rs39819 chr5:122301676 G/A cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.2 0.32 1.69e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs11630290 0.592 rs8028348 chr15:64156465 A/G cg12036633 chr15:63758958 NA 0.53 6.84 0.35 3.73e-11 Iris characteristics; LUSC cis rs113835537 0.935 rs11550057 chr11:66392880 C/T cg24851651 chr11:66362959 CCS 0.53 6.55 0.34 2.14e-10 Airway imaging phenotypes; LUSC trans rs1962073 0.623 rs7459532 chr8:10261068 C/T cg15556689 chr8:8085844 FLJ10661 -0.48 -6.78 -0.35 5.3e-11 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); LUSC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg19346786 chr7:2764209 NA -0.41 -7.05 -0.36 1e-11 Height; LUSC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.7 0.39 1.61e-13 Major depressive disorder; LUSC cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg12011299 chr4:100065546 ADH4 -0.72 -11.23 -0.52 4.82e-25 Alcohol dependence; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg22166914 chr1:53195759 ZYG11B 0.48 7.61 0.38 2.74e-13 Monocyte count; LUSC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs1577917 0.958 rs10944144 chr6:86537755 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.82 -0.43 6.58e-17 Response to antipsychotic treatment; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg23284646 chr4:17616339 MED28 0.5 6.31 0.33 9.01e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4363385 0.669 rs4845519 chr1:153003916 G/T cg00922841 chr1:152955080 SPRR1A 0.43 7.61 0.38 2.76e-13 Inflammatory skin disease; LUSC cis rs8028182 0.537 rs4371118 chr15:75898890 C/G cg20655648 chr15:75932815 IMP3 0.42 5.82 0.3 1.42e-8 Sudden cardiac arrest; LUSC trans rs12210905 0.688 rs12196452 chr6:27344415 A/T cg02699829 chr19:13216355 TRMT1 -0.56 -6.33 -0.33 7.7e-10 Hip circumference adjusted for BMI; LUSC cis rs1790761 0.692 rs674783 chr11:67339076 C/T cg00864171 chr11:67383662 NA 0.35 6.14 0.32 2.31e-9 Mean corpuscular volume; LUSC cis rs9467711 0.606 rs35307327 chr6:26370474 C/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.86e-11 Aortic root size; LUSC cis rs939658 0.683 rs11634726 chr15:79465894 A/G cg17916960 chr15:79447300 NA -0.44 -8.22 -0.41 4.56e-15 Refractive error; LUSC cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg04455712 chr21:45112962 RRP1B 0.41 7.55 0.38 4.13e-13 Mean corpuscular volume; LUSC cis rs9430161 0.579 rs11121669 chr1:11039567 T/C cg27631724 chr1:11040367 C1orf127 0.55 10.58 0.5 9.33e-23 Ewing sarcoma; LUSC cis rs34779708 0.931 rs58159560 chr10:35351249 C/T cg03585969 chr10:35415529 CREM 0.62 8.93 0.44 2.97e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg12310025 chr6:25882481 NA -0.47 -7.22 -0.37 3.47e-12 Intelligence (multi-trait analysis); LUSC cis rs6969780 0.915 rs12666919 chr7:27189498 A/T cg26364809 chr7:27145159 NA 0.53 5.92 0.31 7.97e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs983392 0.649 rs7936120 chr11:60000574 T/A cg24026212 chr11:59952134 MS4A6A -0.35 -6.08 -0.32 3.22e-9 Alzheimer's disease (late onset); LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg08470875 chr2:26401718 FAM59B 0.73 9.87 0.48 2.53e-20 Gut microbiome composition (summer); LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg13560548 chr3:10150139 C3orf24 -0.5 -6.97 -0.36 1.66e-11 Alzheimer's disease; LUSC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg06558623 chr16:89946397 TCF25 -0.83 -8.89 -0.44 3.93e-17 Skin colour saturation; LUSC cis rs317689 0.690 rs317646 chr12:69657145 A/G cg11871910 chr12:69753446 YEATS4 -0.45 -5.96 -0.31 6.31e-9 Response to diuretic therapy; LUSC cis rs77106637 0.932 rs2886599 chr11:72721271 C/A cg03878208 chr11:72483293 STARD10 0.58 7.43 0.38 9.24e-13 Type 2 diabetes; LUSC cis rs7772486 0.875 rs7739418 chr6:146359188 G/A cg23711669 chr6:146136114 FBXO30 0.85 15.18 0.64 6.02e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs6547741 0.904 rs1528403 chr2:27846645 C/G cg12559939 chr2:27858050 GPN1 0.38 5.79 0.3 1.62e-8 Oral cavity cancer; LUSC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg08773314 chr2:239334832 ASB1 -0.43 -9.32 -0.45 1.6e-18 Multiple system atrophy; LUSC cis rs16976116 0.901 rs1061874 chr15:55496287 A/T cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1023500 0.551 rs133355 chr22:42440285 G/A cg05082376 chr22:42548792 NA -0.39 -5.82 -0.3 1.41e-8 Schizophrenia; LUSC cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg01256987 chr12:42539512 GXYLT1 -0.45 -8.73 -0.43 1.23e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7264396 0.667 rs224368 chr20:34070380 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -5.94 -0.31 7.13e-9 Total cholesterol levels; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.45 5.99 0.31 5.34e-9 Renal function-related traits (BUN); LUSC cis rs2845885 0.793 rs3751120 chr11:63884453 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.76 7.87 0.4 5.12e-14 Body mass index; LUSC cis rs4589502 0.512 rs7183242 chr15:67096658 A/G cg09911534 chr15:67153556 NA -0.6 -9.79 -0.47 4.54e-20 Lung cancer (smoking interaction); LUSC cis rs4409675 0.548 rs1000432 chr1:28225119 T/C cg23691781 chr1:28212827 C1orf38 0.31 7.43 0.38 9.31e-13 Corneal astigmatism; LUSC cis rs1552244 0.507 rs6443274 chr3:9995288 A/T cg13047869 chr3:10149882 C3orf24 0.44 6.79 0.35 5.06e-11 Alzheimer's disease; LUSC cis rs9902453 0.934 rs34433787 chr17:28496780 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.18 0.41 5.84e-15 Coffee consumption (cups per day); LUSC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15541040 chr2:3486749 NA -0.58 -9.1 -0.45 8.15e-18 Neurofibrillary tangles; LUSC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg05347473 chr6:146136440 FBXO30 0.55 9.47 0.46 5.36e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs4780401 0.609 rs16958588 chr16:11819330 G/A cg01061890 chr16:11836724 TXNDC11 -0.56 -8.58 -0.42 3.69e-16 Rheumatoid arthritis; LUSC cis rs9359856 0.510 rs6454775 chr6:90465000 A/T cg13799429 chr6:90582589 CASP8AP2 0.92 10.97 0.51 4.11e-24 Bipolar disorder; LUSC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg11871910 chr12:69753446 YEATS4 0.93 17.13 0.68 1.14e-47 Cerebrospinal fluid biomarker levels; LUSC cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg06191203 chr2:152266755 RIF1 0.53 7.33 0.37 1.75e-12 Lung cancer; LUSC cis rs10197940 0.662 rs10173699 chr2:152281561 C/G cg19508488 chr2:152266495 RIF1 -0.51 -7.32 -0.37 1.9e-12 Lung cancer; LUSC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.48 0.38 6.75e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs13108904 0.870 rs3733338 chr4:1241472 G/A cg02475777 chr4:1388615 CRIPAK 0.41 6.11 0.32 2.76e-9 Obesity-related traits; LUSC cis rs7188861 0.510 rs35307035 chr16:11402908 G/A cg00044050 chr16:11439710 C16orf75 0.58 6.26 0.32 1.21e-9 HDL cholesterol; LUSC cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg12310025 chr6:25882481 NA 0.63 10.52 0.5 1.5e-22 Blood metabolite levels; LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg14092988 chr3:52407081 DNAH1 0.31 6.15 0.32 2.23e-9 Bipolar disorder; LUSC cis rs1003719 0.680 rs2835620 chr21:38505581 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg13602798 chr17:8152519 PFAS;C17orf68 -0.44 -6.71 -0.34 8.32e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg20503657 chr10:835505 NA 0.97 13.45 0.59 2.98e-33 Eosinophil percentage of granulocytes; LUSC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg12564285 chr5:131593104 PDLIM4 0.39 7.12 0.36 6.85e-12 Breast cancer; LUSC cis rs870825 0.616 rs877276 chr4:185621249 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs2346177 0.576 rs1530621 chr2:46688688 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.59 -9.0 -0.44 1.79e-17 HDL cholesterol; LUSC cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg09436375 chr6:42928200 GNMT -0.29 -6.51 -0.34 2.8e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg23260525 chr10:116636907 FAM160B1 0.49 10.57 0.5 1.04e-22 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs11992162 0.569 rs11786149 chr8:11800818 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.47 -0.33 3.51e-10 Monocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12774482 chr13:50656354 DLEU1;DLEU2 -0.43 -6.89 -0.35 2.7e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2046867 0.862 rs6766747 chr3:72856551 T/C cg04365224 chr3:72788183 NA -0.46 -5.76 -0.3 1.88e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.58 8.78 0.43 8.82e-17 Lymphocyte counts; LUSC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.49 -0.38 6.39e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg18876405 chr7:65276391 NA -0.7 -12.22 -0.56 1.21e-28 Aortic root size; LUSC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg20891283 chr12:69753455 YEATS4 0.94 18.17 0.71 8.64e-52 Cerebrospinal fluid biomarker levels; LUSC cis rs8014204 0.967 rs1319171 chr14:75334096 G/T cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.3 -0.53 2.71e-25 Caffeine consumption; LUSC cis rs6547741 0.935 rs4665384 chr2:27848397 A/G cg27432699 chr2:27873401 GPN1 0.83 15.87 0.66 1.14e-42 Oral cavity cancer; LUSC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg17366294 chr4:99064904 C4orf37 0.56 9.85 0.47 2.83e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2274273 0.516 rs10137071 chr14:55370340 C/T cg04306507 chr14:55594613 LGALS3 0.32 6.0 0.31 5.19e-9 Protein biomarker; LUSC cis rs9457247 0.967 rs382009 chr6:167403121 G/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs9905704 0.647 rs2036730 chr17:57038282 A/G cg12560992 chr17:57184187 TRIM37 0.58 9.32 0.45 1.64e-18 Testicular germ cell tumor; LUSC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg23711669 chr6:146136114 FBXO30 0.88 15.89 0.66 9.37e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs2197308 0.715 rs11181816 chr12:37911626 A/G cg26384229 chr12:38710491 ALG10B -0.82 -13.55 -0.6 1.28e-33 Morning vs. evening chronotype; LUSC cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg27279351 chr12:120934652 DYNLL1 0.61 8.02 0.4 1.8e-14 High light scatter reticulocyte count; LUSC cis rs10875595 0.836 rs10062604 chr5:140661932 T/C cg24830062 chr5:140700576 TAF7 -0.52 -6.31 -0.33 9.1e-10 Pulmonary function decline; LUSC cis rs9297145 0.565 rs4729516 chr7:98745679 G/A cg05967295 chr7:98741636 SMURF1 -0.64 -10.08 -0.48 4.9e-21 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2404602 0.647 rs11855296 chr15:77092962 C/T cg23625390 chr15:77176239 SCAPER -0.65 -9.69 -0.47 9.8e-20 Blood metabolite levels; LUSC cis rs9807989 0.507 rs6710528 chr2:103016142 A/G cg03938978 chr2:103052716 IL18RAP -0.37 -7.05 -0.36 1e-11 Asthma; LUSC cis rs11024102 0.830 rs11024110 chr11:17028390 T/A cg15084286 chr11:17036142 PLEKHA7 0.46 6.36 0.33 6.54e-10 Glaucoma (primary angle closure); LUSC cis rs34375054 0.672 rs10400509 chr12:125592173 T/C cg09839279 chr12:125627357 AACS -0.35 -6.36 -0.33 6.79e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9818758 0.556 rs116432667 chr3:48947589 C/T cg00383909 chr3:49044727 WDR6 1.3 11.92 0.55 1.51e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs11229555 0.609 rs12270515 chr11:58217945 G/A cg15696309 chr11:58395628 NA -0.61 -7.43 -0.38 9e-13 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4631830 0.720 rs4935573 chr10:51504385 A/G cg16070123 chr10:51489643 NA 0.55 9.19 0.45 4.36e-18 Prostate-specific antigen levels; LUSC cis rs3796619 0.503 rs1466216 chr4:1071907 C/T cg27284194 chr4:1044797 NA -0.74 -15.36 -0.64 1.13e-40 Recombination rate (males); LUSC cis rs11155671 0.530 rs2342770 chr6:150216685 C/T cg13206674 chr6:150067644 NUP43 0.41 6.21 0.32 1.56e-9 Testicular germ cell tumor; LUSC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg14668632 chr7:2872130 GNA12 -0.43 -6.7 -0.34 9.06e-11 Height; LUSC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg06618935 chr21:46677482 NA -0.38 -7.03 -0.36 1.18e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs698813 0.763 rs786615 chr2:44590608 T/C cg00619915 chr2:44497795 NA -0.42 -6.01 -0.31 4.9e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg00166722 chr3:10149974 C3orf24 0.6 8.59 0.43 3.36e-16 Alzheimer's disease; LUSC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg06221963 chr1:154839813 KCNN3 -0.6 -13.65 -0.6 5.11e-34 Prostate cancer; LUSC cis rs1670533 0.872 rs13108222 chr4:1054256 C/A cg16405210 chr4:1374714 KIAA1530 -0.46 -5.64 -0.3 3.56e-8 Recombination rate (females); LUSC trans rs1493916 0.721 rs4471760 chr18:31374233 G/A cg27147174 chr7:100797783 AP1S1 -0.65 -10.45 -0.5 2.64e-22 Life satisfaction; LUSC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg05623727 chr3:50126028 RBM5 0.34 6.41 0.33 4.88e-10 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.958 rs12209259 chr6:86502348 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.86 -0.44 4.78e-17 Response to antipsychotic treatment; LUSC cis rs11690935 0.959 rs3770451 chr2:172668715 T/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.67 -0.63 5.64e-38 Schizophrenia; LUSC cis rs7804356 1.000 rs3801810 chr7:26892531 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.15 -0.32 2.27e-9 Type 1 diabetes; LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg18404041 chr3:52824283 ITIH1 -0.63 -12.22 -0.56 1.19e-28 Bipolar disorder; LUSC cis rs7586879 0.638 rs10203482 chr2:25136916 T/C cg01884057 chr2:25150051 NA 0.47 10.84 0.51 1.17e-23 Body mass index; LUSC cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg05347473 chr6:146136440 FBXO30 0.5 8.36 0.42 1.67e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs6866614 0.627 rs27437 chr5:131436961 A/G cg14196790 chr5:131705035 SLC22A5 0.41 6.67 0.34 1.07e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg05165339 chr4:1420672 NA -0.29 -6.43 -0.33 4.37e-10 Longevity; LUSC cis rs295140 0.656 rs3769472 chr2:201193373 G/A cg04283868 chr2:201171347 SPATS2L 0.42 5.89 0.31 9.24e-9 QT interval; LUSC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.85 -0.31 1.14e-8 Total body bone mineral density; LUSC trans rs9393777 0.778 rs66841633 chr6:27382386 G/T cg01620082 chr3:125678407 NA -0.8 -7.23 -0.37 3.4e-12 Intelligence (multi-trait analysis); LUSC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg12463550 chr7:65579703 CRCP 0.44 6.37 0.33 6.16e-10 Aortic root size; LUSC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg25272121 chr1:152190972 HRNR -0.39 -6.73 -0.35 7.42e-11 Inflammatory skin disease; LUSC trans rs12210905 0.925 rs72838262 chr6:27008517 G/C cg11837749 chr1:55047332 ACOT11 0.59 6.29 0.33 1.02e-9 Hip circumference adjusted for BMI; LUSC cis rs10779751 0.734 rs1211575 chr1:11118390 G/A cg04508216 chr1:11107452 MASP2 0.33 5.86 0.31 1.1e-8 Body mass index; LUSC trans rs7726839 0.540 rs4957081 chr5:646418 G/C cg11887960 chr12:57824829 NA 0.52 6.61 0.34 1.55e-10 Obesity-related traits; LUSC cis rs739401 0.572 rs404629 chr11:3077025 A/G cg25174290 chr11:3078921 CARS 0.61 9.56 0.46 2.75e-19 Longevity; LUSC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.75 0.39 1.14e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg10523679 chr1:76189770 ACADM -0.78 -10.54 -0.5 1.25e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs950881 0.867 rs56179005 chr2:102974328 G/A cg20060108 chr2:102954350 IL1RL1 0.47 6.08 0.32 3.37e-9 Allergy; LUSC trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg13615516 chr5:77269221 NA 0.39 6.52 0.34 2.54e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg17366294 chr4:99064904 C4orf37 0.55 9.51 0.46 3.91e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs4730250 0.707 rs10953537 chr7:107027905 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.37 -0.46 1.15e-18 Osteoarthritis; LUSC trans rs561341 0.739 rs8070554 chr17:30216868 A/T cg20587970 chr11:113659929 NA 0.77 9.81 0.47 3.96e-20 Hip circumference adjusted for BMI; LUSC trans rs12709013 0.636 rs1657161 chr16:58777138 C/T cg19313373 chr1:162694184 DDR2 -0.35 -5.96 -0.31 6.55e-9 Blood metabolite ratios; LUSC cis rs12210905 1.000 rs12213361 chr6:27138387 T/C cg11502198 chr6:26597334 ABT1 -0.79 -5.66 -0.3 3.22e-8 Hip circumference adjusted for BMI; LUSC cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs7589728 0.844 rs77144652 chr2:88496684 G/A cg04511125 chr2:88470314 THNSL2 0.68 6.33 0.33 7.78e-10 Plasma clusterin levels; LUSC cis rs7119 0.717 rs12915548 chr15:77818042 A/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC trans rs3960554 0.932 rs60717745 chr7:75846083 C/G cg19862616 chr7:65841803 NCRNA00174 0.89 9.2 0.45 3.86e-18 Eotaxin levels; LUSC cis rs11167764 1.000 rs6887599 chr5:141484349 G/A cg08523384 chr5:141488047 NDFIP1 -0.51 -7.19 -0.37 4.38e-12 Crohn's disease; LUSC cis rs7923609 0.936 rs10761779 chr10:65274927 A/G cg01631684 chr10:65280961 REEP3 -0.42 -6.56 -0.34 2.02e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7666738 0.515 rs13434650 chr4:98889886 A/G cg03676636 chr4:99064102 C4orf37 0.3 6.1 0.32 2.86e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2580764 0.566 rs2968795 chr2:55287989 G/A cg09592903 chr2:55203963 RTN4 0.49 9.95 0.48 1.39e-20 Mean platelet volume; LUSC trans rs931812 0.825 rs34235568 chr8:101895761 C/T cg20993868 chr7:22813445 NA 0.58 10.03 0.48 7.32e-21 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs61931739 0.658 rs4476006 chr12:34237154 A/C cg06521331 chr12:34319734 NA -0.38 -6.55 -0.34 2.2e-10 Morning vs. evening chronotype; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg03039008 chr3:150126185 TSC22D2 -0.41 -6.02 -0.31 4.56e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.51e-15 Axial length; LUSC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg14298792 chr15:30685198 CHRFAM7A 0.64 8.36 0.42 1.71e-15 Huntington's disease progression; LUSC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg10130564 chr11:117069849 TAGLN 0.38 6.59 0.34 1.68e-10 Blood protein levels; LUSC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg22437258 chr11:111473054 SIK2 0.51 7.04 0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg20684491 chr1:25596433 NA 0.4 6.36 0.33 6.71e-10 Erythrocyte sedimentation rate; LUSC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg17211192 chr8:82754475 SNX16 -0.82 -11.22 -0.52 5.21e-25 Diastolic blood pressure; LUSC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs9346649 0.591 rs1873338 chr6:168492087 T/C cg02770688 chr6:168491649 NA 0.48 9.08 0.45 9.54e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs2286885 1.000 rs7851961 chr9:129249140 G/A cg15282417 chr9:129245246 FAM125B 0.38 6.34 0.33 7.36e-10 Intraocular pressure; LUSC cis rs3858526 0.834 rs6578712 chr11:5987071 C/T cg02574844 chr11:5959923 NA -0.45 -6.24 -0.32 1.35e-9 DNA methylation (variation); LUSC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg21573476 chr21:45109991 RRP1B -0.41 -6.66 -0.34 1.11e-10 Mean corpuscular volume; LUSC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg18230493 chr5:56204884 C5orf35 -0.55 -8.7 -0.43 1.57e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg00750074 chr16:89608354 SPG7 -0.55 -9.91 -0.48 1.83e-20 Multiple myeloma (IgH translocation); LUSC cis rs1150668 0.830 rs2859365 chr6:28391465 C/T cg21251018 chr6:28226885 NKAPL -0.31 -5.84 -0.3 1.27e-8 Pubertal anthropometrics; LUSC trans rs12210905 0.925 rs12200985 chr6:27004892 G/T cg11837749 chr1:55047332 ACOT11 0.59 6.28 0.32 1.05e-9 Hip circumference adjusted for BMI; LUSC cis rs11676348 0.710 rs11894169 chr2:219046846 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.39 5.94 0.31 7.07e-9 Ulcerative colitis; LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg27170947 chr2:26402098 FAM59B -0.64 -9.37 -0.46 1.1e-18 Gut microbiome composition (summer); LUSC cis rs500891 0.547 rs1145900 chr6:84038920 T/C cg08257003 chr6:84140564 ME1 0.32 7.13 0.36 6.15e-12 Platelet-derived growth factor BB levels; LUSC trans rs11696501 0.688 rs11696685 chr20:44295134 A/G cg03272292 chr12:48577362 C12orf68 0.48 6.0 0.31 5.1e-9 Brain structure; LUSC trans rs11098499 0.954 rs2892848 chr4:120381341 C/T cg25214090 chr10:38739885 LOC399744 0.56 8.16 0.41 7.08e-15 Corneal astigmatism; LUSC cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg18512352 chr11:47633146 NA -0.46 -9.22 -0.45 3.51e-18 Subjective well-being; LUSC cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg07606381 chr6:8435919 SLC35B3 0.75 12.72 0.57 1.74e-30 Motion sickness; LUSC cis rs9612 0.950 rs60649310 chr19:44269241 A/G cg08581076 chr19:44259116 C19orf61 0.48 5.75 0.3 1.97e-8 Exhaled nitric oxide output; LUSC cis rs7927592 0.913 rs67005337 chr11:68307758 A/C cg16797656 chr11:68205561 LRP5 0.38 6.22 0.32 1.52e-9 Total body bone mineral density; LUSC cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg17971929 chr21:40555470 PSMG1 0.67 11.14 0.52 9.98e-25 Cognitive function; LUSC cis rs6681460 0.934 rs4655635 chr1:67068240 T/G cg02459107 chr1:67143332 SGIP1 0.45 8.29 0.41 2.84e-15 Presence of antiphospholipid antibodies; LUSC cis rs4629180 0.562 rs10198901 chr2:102127937 G/A cg01388757 chr2:102091195 RFX8 -0.36 -6.41 -0.33 4.96e-10 Chronic rhinosinusitis with nasal polyps; LUSC cis rs1550582 0.662 rs7812708 chr8:135500832 C/T cg17885191 chr8:135476712 NA 0.88 14.3 0.62 1.61e-36 Educational attainment; LUSC cis rs73001065 1.000 rs56255430 chr19:19477877 A/C cg03709012 chr19:19516395 GATAD2A 0.99 7.55 0.38 4.06e-13 LDL cholesterol; LUSC cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg06462663 chr19:18546047 ISYNA1 0.5 8.56 0.42 4.2e-16 Breast cancer; LUSC cis rs28489187 0.577 rs3920521 chr1:85848866 A/C cg02862864 chr1:85742044 BCL10 -0.42 -5.77 -0.3 1.86e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.18 15.2 0.64 5.15e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1018697 1.000 rs1018696 chr10:104549066 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.45 0.33 4.04e-10 Colorectal adenoma (advanced); LUSC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg11494091 chr17:61959527 GH2 0.39 6.77 0.35 5.68e-11 Height; LUSC cis rs2073300 1.000 rs2207988 chr20:23446000 C/A cg09953122 chr20:23471693 CST8 -0.75 -6.87 -0.35 3.15e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs57786342 0.624 rs4899262 chr14:69283545 G/A cg03189333 chr14:69283534 NA -0.48 -5.99 -0.31 5.58e-9 Macrophage inflammatory protein 1a levels; LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg02951883 chr7:2050386 MAD1L1 -0.35 -6.09 -0.32 3.08e-9 Bipolar disorder and schizophrenia; LUSC trans rs804280 0.518 rs34266352 chr8:11791462 G/A cg27411982 chr8:10470053 RP1L1 0.4 6.1 0.32 2.91e-9 Myopia (pathological); LUSC cis rs1595825 0.891 rs57990618 chr2:198660838 C/T cg10547527 chr2:198650123 BOLL -0.49 -5.72 -0.3 2.4e-8 Ulcerative colitis; LUSC cis rs66887589 0.777 rs1814815 chr4:120258091 C/T cg24375607 chr4:120327624 NA 0.52 8.3 0.41 2.62e-15 Diastolic blood pressure; LUSC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg14403583 chr14:105418241 AHNAK2 -0.58 -9.71 -0.47 8.38e-20 Rheumatoid arthritis; LUSC trans rs6982636 0.765 rs2001945 chr8:126477978 C/G cg13325919 chr3:181432053 SOX2;SOX2OT -0.32 -6.31 -0.33 9.06e-10 Lipid metabolism phenotypes; LUSC cis rs9611565 0.877 rs3817999 chr22:41747717 A/G cg03806693 chr22:41940476 POLR3H 0.72 10.61 0.5 7.35e-23 Vitiligo; LUSC cis rs9309711 0.770 rs13409323 chr2:3488184 C/T cg10845886 chr2:3471009 TTC15 -0.55 -7.03 -0.36 1.15e-11 Neurofibrillary tangles; LUSC cis rs7819412 0.595 rs2409712 chr8:10986837 A/C cg21775007 chr8:11205619 TDH -0.51 -7.39 -0.37 1.17e-12 Triglycerides; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.17 0.52 7.73e-25 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.44 0.38 8.34e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12681288 0.823 rs2701905 chr8:1003482 T/C cg15309053 chr8:964076 NA 0.35 7.16 0.36 5.03e-12 Schizophrenia; LUSC cis rs10992471 0.756 rs1121979 chr9:95140218 G/A cg14631576 chr9:95140430 CENPP -0.33 -5.93 -0.31 7.77e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg03806693 chr22:41940476 POLR3H -0.85 -12.0 -0.55 8.2e-28 Vitiligo; LUSC cis rs1044826 1.000 rs13060697 chr3:139101777 G/A cg00490450 chr3:139108681 COPB2 0.55 7.39 0.37 1.22e-12 Obesity-related traits; LUSC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg23283495 chr1:209979779 IRF6 -0.55 -9.2 -0.45 3.84e-18 Monobrow; LUSC cis rs3892630 0.529 rs35300319 chr19:33409948 G/A cg22980127 chr19:33182716 NUDT19 0.66 8.64 0.43 2.29e-16 Red blood cell traits; LUSC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg16680214 chr1:154839983 KCNN3 -0.52 -9.76 -0.47 5.77e-20 Prostate cancer; LUSC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC trans rs1376359 0.537 rs538840 chr1:103260952 G/T cg17154563 chr19:40477487 PSMC4 0.48 6.06 0.31 3.61e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg26384229 chr12:38710491 ALG10B 0.88 14.84 0.63 1.28e-38 Drug-induced liver injury (flucloxacillin); LUSC trans rs11165623 0.585 rs55896436 chr1:96994162 G/A cg10631902 chr5:14652156 NA -0.41 -6.09 -0.32 3.12e-9 Hip circumference;Waist circumference; LUSC cis rs68170813 0.559 rs58319984 chr7:106965794 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.87 -0.48 2.43e-20 Coronary artery disease; LUSC cis rs2742234 0.541 rs10793426 chr10:43745280 G/A cg07801480 chr10:43725741 RASGEF1A -0.39 -5.67 -0.3 3.06e-8 Hirschsprung disease; LUSC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg18876405 chr7:65276391 NA -0.66 -11.66 -0.54 1.34e-26 Aortic root size; LUSC cis rs13256369 0.802 rs13256404 chr8:8562974 T/C cg18904891 chr8:8559673 CLDN23 0.6 8.08 0.4 1.2e-14 Obesity-related traits; LUSC cis rs73206853 0.841 rs57216167 chr12:110940748 C/T cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7267979 0.966 rs6107031 chr20:25350677 C/T cg03522245 chr20:25566470 NINL -0.35 -5.68 -0.3 2.89e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10097731 0.808 rs80141261 chr8:82034453 T/C cg25230327 chr8:82042993 NA -0.44 -6.5 -0.33 2.98e-10 Serum total protein level; LUSC cis rs9875589 0.509 rs6442423 chr3:14016062 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 7.02 0.36 1.24e-11 Ovarian reserve; LUSC cis rs9325144 0.723 rs10161183 chr12:39182087 T/C cg26384229 chr12:38710491 ALG10B -0.61 -9.3 -0.45 1.95e-18 Morning vs. evening chronotype; LUSC cis rs1949733 0.598 rs4696838 chr4:8540349 A/G cg11789530 chr4:8429930 ACOX3 -0.42 -6.1 -0.32 2.95e-9 Response to antineoplastic agents; LUSC cis rs7568458 0.591 rs55971080 chr2:85812746 T/C cg17127132 chr2:85788382 GGCX 0.45 7.05 0.36 1.05e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7520050 0.902 rs4626927 chr1:46248645 C/T cg24296786 chr1:45957014 TESK2 0.42 5.88 0.31 9.75e-9 Red blood cell count;Reticulocyte count; LUSC cis rs7000551 0.642 rs2122880 chr8:22375042 C/A cg12081754 chr8:22256438 SLC39A14 0.45 6.75 0.35 6.5500000000000006e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs7939886 0.920 rs17145425 chr11:55950030 A/G cg03929089 chr4:120376271 NA 0.83 6.29 0.33 1e-9 Myopia (pathological); LUSC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg17376030 chr22:41985996 PMM1 -0.46 -6.06 -0.31 3.61e-9 Crohn's disease;Inflammatory bowel disease; LUSC trans rs2832077 0.943 rs11701777 chr21:30155828 T/C cg14791747 chr16:20752902 THUMPD1 0.71 9.43 0.46 6.88e-19 Cognitive test performance; LUSC cis rs12893668 0.703 rs2403197 chr14:104053764 C/T cg04998671 chr14:104000505 TRMT61A -0.47 -6.76 -0.35 6.13e-11 Reticulocyte count; LUSC cis rs1371867 0.846 rs2453624 chr8:101230523 A/G cg00191853 chr8:101177733 SPAG1 0.41 6.64 0.34 1.27e-10 Atrioventricular conduction; LUSC cis rs7177699 0.557 rs6495333 chr15:79113215 G/A cg15571903 chr15:79123663 NA 0.32 5.9 0.31 9.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11997175 0.545 rs4733458 chr8:33661542 G/T ch.8.33884649F chr8:33765107 NA 0.49 7.29 0.37 2.2e-12 Body mass index; LUSC cis rs61612642 0.523 rs59004693 chr6:42157392 G/A cg01092361 chr6:42185687 MRPS10 0.78 8.68 0.43 1.78e-16 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg18402987 chr7:1209562 NA 0.71 7.85 0.39 5.89e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1451375 0.572 rs11575463 chr7:50547173 A/G cg18232548 chr7:50535776 DDC -0.53 -7.33 -0.37 1.7e-12 Malaria; LUSC cis rs9325144 0.723 rs10161183 chr12:39182087 T/C cg13010199 chr12:38710504 ALG10B -0.5 -7.59 -0.38 3.32e-13 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9467773 0.620 rs2504540 chr6:26641626 A/G cg11502198 chr6:26597334 ABT1 0.72 12.01 0.55 7.53e-28 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.19 -0.32 1.75e-9 Lung cancer; LUSC cis rs66887589 0.592 rs62320740 chr4:120279486 C/A cg09307838 chr4:120376055 NA 0.57 8.59 0.43 3.46e-16 Diastolic blood pressure; LUSC cis rs612683 0.658 rs12407689 chr1:100999585 C/G cg06223162 chr1:101003688 GPR88 0.52 9.58 0.46 2.31e-19 Breast cancer; LUSC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 10.09 0.48 4.6e-21 Bipolar disorder; LUSC cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg03146154 chr1:46216737 IPP 0.51 7.51 0.38 5.46e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs72634258 0.945 rs4908724 chr1:8119251 G/T cg00042356 chr1:8021962 PARK7 0.83 9.81 0.47 3.83e-20 Inflammatory bowel disease; LUSC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.29 0.45 2.03e-18 Monocyte percentage of white cells; LUSC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -7.38 -0.37 1.29e-12 Axial length; LUSC cis rs317689 0.690 rs7969559 chr12:69655167 A/G cg11871910 chr12:69753446 YEATS4 0.44 6.04 0.31 4.14e-9 Response to diuretic therapy; LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.69 -0.57 2.29e-30 Platelet count; LUSC cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.53e-9 Breast cancer; LUSC cis rs7267979 1.000 rs2259837 chr20:25280205 T/C cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1775715 0.870 rs1775735 chr10:32255846 A/G cg03015672 chr10:32216066 ARHGAP12 0.33 5.69 0.3 2.85e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4906332 0.840 rs34161327 chr14:103857325 G/A cg04998671 chr14:104000505 TRMT61A -0.47 -7.22 -0.37 3.51e-12 Coronary artery disease; LUSC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg05425664 chr17:57184151 TRIM37 0.53 7.9 0.4 4.1e-14 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg01097406 chr16:89675127 NA -0.37 -7.42 -0.38 9.78e-13 Vitiligo; LUSC cis rs7927592 0.913 rs6591344 chr11:68360873 G/A cg01657329 chr11:68192670 LRP5 -0.4 -5.77 -0.3 1.85e-8 Total body bone mineral density; LUSC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 9.31 0.45 1.76e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7592578 0.825 rs12477369 chr2:191455624 G/T cg11845111 chr2:191398756 TMEM194B 0.84 10.73 0.51 2.73e-23 Diastolic blood pressure; LUSC cis rs7705502 1.000 rs1564823 chr5:173383194 G/T cg18693985 chr5:173351052 CPEB4 -0.4 -6.46 -0.33 3.75e-10 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg02022491 chr17:2323612 METT10D -0.35 -5.99 -0.31 5.4e-9 N-glycan levels; LUSC cis rs1451375 0.550 rs10239830 chr7:50603829 A/G cg18232548 chr7:50535776 DDC 0.55 7.35 0.37 1.52e-12 Malaria; LUSC cis rs9341835 0.772 rs9341841 chr6:64135010 G/A cg03326410 chr6:64151739 NA -0.38 -6.26 -0.32 1.15e-9 Schizophrenia; LUSC cis rs7826238 0.509 rs2948288 chr8:8115304 A/G cg08975724 chr8:8085496 FLJ10661 0.65 9.92 0.48 1.72e-20 Systolic blood pressure; LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs1044826 0.619 rs57357132 chr3:139118358 A/T cg00490450 chr3:139108681 COPB2 -0.5 -7.87 -0.4 4.85e-14 Obesity-related traits; LUSC trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg15704280 chr7:45808275 SEPT13 -0.44 -6.01 -0.31 4.86e-9 HDL cholesterol; LUSC cis rs1559088 0.576 rs11084707 chr19:33612873 C/T cg27124370 chr19:33622961 WDR88 0.57 7.93 0.4 3.33e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4285028 0.948 rs1920290 chr3:121672305 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.67 -0.47 1.19e-19 Multiple sclerosis; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg18538332 chr22:24372958 LOC391322 -0.46 -8.05 -0.4 1.48e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7180079 1.000 rs62024569 chr15:64496926 T/C cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg17264618 chr3:40429014 ENTPD3 0.34 6.92 0.35 2.37e-11 Renal cell carcinoma; LUSC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -11.75 -0.54 6.51e-27 Mean corpuscular volume; LUSC cis rs963731 0.649 rs1869514 chr2:39205796 C/T cg04010122 chr2:39346883 SOS1 -0.78 -5.7 -0.3 2.71e-8 Corticobasal degeneration; LUSC trans rs1864729 0.591 rs2635139 chr8:98301557 A/G cg08679828 chr8:102218111 ZNF706 -0.67 -6.3 -0.33 9.28e-10 Estradiol plasma levels (breast cancer); LUSC cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg26384229 chr12:38710491 ALG10B 0.63 10.03 0.48 7.4e-21 Morning vs. evening chronotype; LUSC cis rs12449964 0.524 rs4925094 chr17:17569012 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.52 -8.23 -0.41 4.28e-15 Coronary artery disease or ischemic stroke; LUSC cis rs12291225 0.877 rs11023160 chr11:14264225 T/A cg19336497 chr11:14380999 RRAS2 -0.48 -8.94 -0.44 2.79e-17 Sense of smell; LUSC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg21984481 chr17:79567631 NPLOC4 -0.56 -10.71 -0.51 3.22e-23 Eye color traits; LUSC cis rs9868809 0.505 rs9811027 chr3:48725014 G/C cg00383909 chr3:49044727 WDR6 1.18 10.67 0.5 4.51e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg09491104 chr22:46646882 C22orf40 -0.7 -7.3 -0.37 2.14e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC cis rs11155671 0.530 rs7774787 chr6:150209432 G/A cg13206674 chr6:150067644 NUP43 0.43 6.54 0.34 2.3e-10 Testicular germ cell tumor; LUSC cis rs10045504 0.502 rs72746031 chr5:38743161 G/A cg15396434 chr5:38725168 NA -0.51 -5.67 -0.3 3.17e-8 Night sleep phenotypes; LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg24060327 chr5:131705240 SLC22A5 -0.65 -11.16 -0.52 8.27e-25 Breast cancer; LUSC cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg11244672 chr19:19639970 YJEFN3 -0.61 -7.52 -0.38 5e-13 Bipolar disorder; LUSC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg09085632 chr11:111637200 PPP2R1B 1.0 15.54 0.65 2.26e-41 Primary sclerosing cholangitis; LUSC cis rs4363385 0.643 rs11576457 chr1:152918556 C/T cg07796016 chr1:152779584 LCE1C 0.51 7.59 0.38 3.23e-13 Inflammatory skin disease; LUSC cis rs7177699 0.526 rs7165733 chr15:79123505 G/A cg00540400 chr15:79124168 NA 0.43 7.51 0.38 5.44e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs62408225 0.802 rs4706360 chr6:90913548 C/T cg06866423 chr6:90926672 BACH2 0.46 7.03 0.36 1.21e-11 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9302635 0.678 rs8054585 chr16:72225314 G/A cg01557791 chr16:72042693 DHODH -0.41 -5.65 -0.3 3.42e-8 Blood protein levels; LUSC cis rs6906287 0.625 rs9489355 chr6:118685314 A/G cg21191810 chr6:118973309 C6orf204 0.37 6.76 0.35 6.11e-11 Electrocardiographic conduction measures; LUSC cis rs453301 0.686 rs7017868 chr8:8873293 G/A cg15556689 chr8:8085844 FLJ10661 -0.61 -9.44 -0.46 6.52e-19 Joint mobility (Beighton score); LUSC cis rs6087771 0.926 rs6058431 chr20:30297133 C/T cg13852791 chr20:30311386 BCL2L1 0.92 13.81 0.6 1.2e-34 Subcortical brain region volumes;Putamen volume; LUSC cis rs9527 0.590 rs12355120 chr10:104852166 T/G cg23093090 chr10:104574429 C10orf26 -0.37 -6.79 -0.35 5.01e-11 Arsenic metabolism; LUSC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg14403583 chr14:105418241 AHNAK2 -0.58 -9.66 -0.47 1.29e-19 Rheumatoid arthritis; LUSC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.69e-9 Systolic blood pressure; LUSC cis rs62408225 0.963 rs1321859 chr6:91011673 C/T cg06866423 chr6:90926672 BACH2 0.41 5.99 0.31 5.3300000000000004e-09 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg19920283 chr7:105172520 RINT1 0.58 6.25 0.32 1.25e-9 Bipolar disorder (body mass index interaction); LUSC trans rs9510787 1.000 rs35520244 chr13:24190488 G/T cg20646490 chr19:45971291 FOSB -0.51 -5.99 -0.31 5.48e-9 Nasopharyngeal carcinoma; LUSC cis rs7824557 0.545 rs2572450 chr8:11229638 C/T cg21775007 chr8:11205619 TDH -0.68 -10.45 -0.5 2.66e-22 Retinal vascular caliber; LUSC cis rs911555 0.755 rs8010247 chr14:103933556 A/G cg24130564 chr14:104152367 KLC1 0.45 6.46 0.33 3.78e-10 Intelligence (multi-trait analysis); LUSC trans rs72674100 0.867 rs4292338 chr4:97963600 G/T cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg23630131 chr7:65973040 NA -0.21 -6.07 -0.31 3.56e-9 Aortic root size; LUSC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg07870213 chr5:140052090 DND1 -0.75 -11.28 -0.53 3.08e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs73198271 0.740 rs10094270 chr8:8646633 G/A cg01851573 chr8:8652454 MFHAS1 0.53 8.42 0.42 1.09e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2204008 0.547 rs12318267 chr12:38250905 T/G cg26384229 chr12:38710491 ALG10B -0.57 -8.58 -0.42 3.75e-16 Bladder cancer; LUSC cis rs2219968 0.962 rs3884556 chr8:78939959 T/C cg00738934 chr8:78996279 NA 0.4 7.15 0.36 5.57e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.53 -0.46 3.42e-19 Chronic sinus infection; LUSC cis rs13385 0.813 rs6859064 chr5:139663301 A/T cg26211634 chr5:139558579 C5orf32 0.44 6.13 0.32 2.46e-9 Atrial fibrillation; LUSC cis rs894734 1.000 rs894734 chr12:54319727 A/G cg17410650 chr12:54324560 NA -0.4 -7.36 -0.37 1.48e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs6961069 0.503 rs3211822 chr7:80278626 A/G cg04458919 chr7:80252533 CD36 0.39 6.84 0.35 3.9e-11 Platelet count; LUSC cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg06108461 chr20:60628389 TAF4 -0.75 -12.39 -0.56 2.79e-29 Body mass index; LUSC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg20135002 chr11:47629003 NA -0.51 -8.04 -0.4 1.59e-14 Subjective well-being; LUSC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11644478 chr21:40555479 PSMG1 -0.79 -13.88 -0.6 6.76e-35 Cognitive function; LUSC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.5e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs12313068 0.709 rs11829777 chr12:110503770 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 9.66 0.47 1.25e-19 Intelligence (multi-trait analysis); LUSC cis rs7212590 0.655 rs8072050 chr17:58010972 G/A cg10252138 chr17:58120427 NA -0.82 -7.64 -0.39 2.33e-13 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg02475777 chr4:1388615 CRIPAK 0.44 6.5 0.34 2.92e-10 Obesity-related traits; LUSC cis rs6424115 0.830 rs2501423 chr1:24199026 A/C cg10978503 chr1:24200527 CNR2 0.53 12.93 0.58 2.88e-31 Immature fraction of reticulocytes; LUSC cis rs79349575 0.721 rs9904645 chr17:46969665 A/T cg22482690 chr17:47019901 SNF8 0.4 7.48 0.38 6.49e-13 Type 2 diabetes; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs7590368 0.715 rs12463454 chr2:10958235 G/A cg15705551 chr2:10952987 PDIA6 0.57 6.23 0.32 1.41e-9 Educational attainment (years of education); LUSC cis rs1775715 0.644 rs2799022 chr10:32137198 C/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.75 0.35 6.67e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7909074 0.865 rs10900123 chr10:45376574 C/T cg04218760 chr10:45406644 TMEM72 -0.29 -6.99 -0.36 1.49e-11 Mean corpuscular volume; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.14 0.41 8.18e-15 Prudent dietary pattern; LUSC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg02825527 chr7:2087843 MAD1L1 -0.5 -5.73 -0.3 2.29e-8 Bipolar disorder; LUSC trans rs10506458 0.834 rs12426860 chr12:63387948 C/T cg22491629 chr6:157744540 C6orf35 -0.88 -10.65 -0.5 5.24e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg08975724 chr8:8085496 FLJ10661 0.46 6.47 0.33 3.54e-10 Mean corpuscular volume; LUSC cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.45 0.42 8.88e-16 Motion sickness; LUSC cis rs595982 0.559 rs73061632 chr19:49361663 G/A cg15549821 chr19:49342101 PLEKHA4 -0.61 -8.32 -0.41 2.32e-15 Red cell distribution width; LUSC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs34421088 0.560 rs2618434 chr8:11398865 A/G cg08975724 chr8:8085496 FLJ10661 -0.52 -7.87 -0.4 4.95e-14 Neuroticism; LUSC cis rs4974559 0.739 rs10012819 chr4:1324758 G/C cg02980000 chr4:1222292 CTBP1 0.97 9.05 0.44 1.17e-17 Systolic blood pressure; LUSC trans rs1493916 1.000 rs7238717 chr18:31395186 C/T cg27147174 chr7:100797783 AP1S1 -0.65 -10.24 -0.49 1.39e-21 Life satisfaction; LUSC trans rs17685 0.753 rs4732595 chr7:75755139 A/G cg19862616 chr7:65841803 NCRNA00174 1.1 18.31 0.71 2.31e-52 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1215050 0.755 rs1238462 chr4:98850603 A/G cg05340658 chr4:99064831 C4orf37 -0.44 -6.95 -0.36 1.94e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg08499158 chr17:42289980 UBTF -0.58 -9.33 -0.45 1.5e-18 Total body bone mineral density; LUSC cis rs847577 0.609 rs11765552 chr7:97822115 T/A cg24562669 chr7:97807699 LMTK2 0.48 8.56 0.42 4.18e-16 Breast cancer; LUSC cis rs2879627 0.504 rs6480583 chr10:53673125 C/T cg06976598 chr10:53639124 PRKG1 0.43 5.7 0.3 2.61e-8 Coronary artery disease; LUSC cis rs9325144 0.600 rs10785615 chr12:38733627 G/C cg26384229 chr12:38710491 ALG10B 0.6 9.49 0.46 4.6e-19 Morning vs. evening chronotype; LUSC cis rs314370 0.951 rs12705095 chr7:100484381 T/G cg18683606 chr7:100471612 SRRT 0.45 6.0 0.31 5.05e-9 Resting heart rate; LUSC trans rs877282 0.853 rs12763400 chr10:763617 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.42 -0.33 4.59e-10 Uric acid levels; LUSC cis rs9467773 1.000 rs4713008 chr6:26538268 T/C cg09904177 chr6:26538194 HMGN4 0.75 14.15 0.61 5.95e-36 Intelligence (multi-trait analysis); LUSC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12756686 chr19:29218302 NA 0.68 9.28 0.45 2.12e-18 Methadone dose in opioid dependence; LUSC cis rs7582180 0.903 rs7557977 chr2:100897573 G/A cg08017756 chr2:100939284 LONRF2 -0.37 -6.18 -0.32 1.83e-9 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg09034736 chr1:150693464 HORMAD1 0.41 5.75 0.3 1.96e-8 Melanoma; LUSC cis rs7582180 0.629 rs11685406 chr2:100946638 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs9323205 0.677 rs8014210 chr14:51709802 T/C cg23942311 chr14:51606299 NA -0.42 -8.0 -0.4 2e-14 Cancer; LUSC cis rs13315871 0.929 rs11717783 chr3:58267642 A/T cg12435725 chr3:58293450 RPP14 -0.78 -7.71 -0.39 1.45e-13 Cholesterol, total; LUSC trans rs28647808 0.881 rs28461467 chr9:136261288 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg00800038 chr16:89945340 TCF25 -0.75 -6.56 -0.34 2.09e-10 Skin colour saturation; LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg24829409 chr8:58192753 C8orf71 -0.47 -6.0 -0.31 5.11e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg22535103 chr8:58192502 C8orf71 -0.56 -6.74 -0.35 6.89e-11 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg23158103 chr7:148848205 ZNF398 -0.47 -7.92 -0.4 3.57e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2302777 0.507 rs9889711 chr17:38108292 A/T cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -9.19 -0.45 4.25e-18 Multiple myeloma (hyperdiploidy); LUSC cis rs911119 1.000 rs3827143 chr20:23619617 A/G cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg13393036 chr8:95962371 TP53INP1 -0.31 -6.18 -0.32 1.91e-9 Type 2 diabetes; LUSC cis rs8141529 0.732 rs3788409 chr22:29198151 T/G cg02153584 chr22:29168773 CCDC117 0.66 10.59 0.5 8.62e-23 Lymphocyte counts; LUSC cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs79349575 0.756 rs4793605 chr17:47035869 T/C cg22482690 chr17:47019901 SNF8 0.38 7.01 0.36 1.35e-11 Type 2 diabetes; LUSC cis rs9914988 0.943 rs4795457 chr17:27087929 C/T cg09479241 chr17:27052676 TLCD1 0.43 5.78 0.3 1.68e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7769051 1.000 rs6910639 chr6:133120553 A/G cg07930552 chr6:133119739 C6orf192 0.85 10.62 0.5 6.83e-23 Type 2 diabetes nephropathy; LUSC cis rs4834770 0.685 rs4496567 chr4:120175625 A/T cg24375607 chr4:120327624 NA 0.42 5.82 0.3 1.39e-8 Blood protein levels; LUSC cis rs2219968 0.740 rs4478563 chr8:78919823 A/G cg00738934 chr8:78996279 NA 0.32 5.67 0.3 3.11e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs500891 0.547 rs12195417 chr6:84173028 T/C cg08257003 chr6:84140564 ME1 0.3 6.74 0.35 6.86e-11 Platelet-derived growth factor BB levels; LUSC cis rs4812048 0.689 rs151356 chr20:57607949 G/A cg14073986 chr20:57617431 SLMO2 0.5 5.76 0.3 1.93e-8 Mean platelet volume; LUSC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg27539214 chr16:67997921 SLC12A4 -0.58 -7.75 -0.39 1.11e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs2191566 0.960 rs2270196 chr19:44506623 A/G cg03039196 chr19:44506973 ZNF230 -0.34 -5.65 -0.3 3.39e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs2806561 0.765 rs623988 chr1:23519477 C/T cg19743168 chr1:23544995 NA 0.4 7.89 0.4 4.25e-14 Height; LUSC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg10018233 chr7:150070692 REPIN1 0.37 6.43 0.33 4.29e-10 Blood protein levels;Circulating chemerin levels; LUSC trans rs6952808 1.000 rs4449693 chr7:1884630 G/C cg24247370 chr13:99142703 STK24 -0.34 -6.24 -0.32 1.35e-9 Bipolar disorder and schizophrenia; LUSC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg06873352 chr17:61820015 STRADA 0.56 8.63 0.43 2.6e-16 Height; LUSC cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg21535247 chr6:8435926 SLC35B3 0.57 9.02 0.44 1.5e-17 Motion sickness; LUSC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg17507749 chr15:85114479 UBE2QP1 0.68 8.72 0.43 1.36e-16 Schizophrenia; LUSC cis rs2742234 0.541 rs60845448 chr10:43721462 C/T cg15436174 chr10:43711423 RASGEF1A 0.44 7.06 0.36 9.75e-12 Hirschsprung disease; LUSC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg08219700 chr8:58056026 NA 0.47 6.21 0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg03806693 chr22:41940476 POLR3H -1.0 -14.25 -0.61 2.51e-36 Vitiligo; LUSC trans rs8072100 0.840 rs56952963 chr17:45493826 T/C cg03886242 chr7:26192032 NFE2L3 -0.39 -6.38 -0.33 5.77e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs34779708 0.931 rs2505631 chr10:35368385 A/T cg03585969 chr10:35415529 CREM -0.58 -8.57 -0.42 3.98e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.55 -0.34 2.2e-10 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs17030434 1.000 rs75083896 chr4:154719082 A/G cg14289246 chr4:154710475 SFRP2 -0.53 -6.84 -0.35 3.69e-11 Electrocardiographic conduction measures; LUSC cis rs1322512 0.917 rs911921 chr6:152992740 C/T cg27316956 chr6:152958899 SYNE1 0.37 6.32 0.33 8.37e-10 Tonometry; LUSC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg21573476 chr21:45109991 RRP1B -0.37 -5.96 -0.31 6.34e-9 Mean corpuscular volume; LUSC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -8.65 -0.43 2.18e-16 Developmental language disorder (linguistic errors); LUSC trans rs17683430 0.557 rs4821012 chr22:32387985 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5.04e-9 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.91 12.92 0.58 2.96e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg23172400 chr8:95962367 TP53INP1 -0.3 -5.81 -0.3 1.49e-8 Type 2 diabetes; LUSC cis rs926938 0.618 rs360617 chr1:115404099 G/A cg01522456 chr1:115632236 TSPAN2 -0.4 -6.36 -0.33 6.64e-10 Autism; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.14 0.41 8.18e-15 Prudent dietary pattern; LUSC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg06212747 chr3:49208901 KLHDC8B 0.44 5.98 0.31 5.78e-9 Parkinson's disease; LUSC cis rs7582180 0.629 rs4850926 chr2:100954117 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.74 0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs10465746 0.935 rs6687372 chr1:84447634 C/T cg10977910 chr1:84465055 TTLL7 0.44 6.37 0.33 6.11e-10 Obesity-related traits; LUSC cis rs7809950 0.678 rs79902674 chr7:106866498 A/C cg23024343 chr7:107201750 COG5 -0.66 -9.34 -0.46 1.35e-18 Coronary artery disease; LUSC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg24690094 chr11:67383802 NA 0.44 8.74 0.43 1.11e-16 Mean corpuscular volume; LUSC cis rs4363385 1.000 rs10888527 chr1:153001363 G/T cg00922841 chr1:152955080 SPRR1A 0.48 8.18 0.41 6e-15 Inflammatory skin disease; LUSC cis rs4953318 0.704 rs10495927 chr2:46352499 A/G cg12428440 chr2:46370979 PRKCE 0.42 7.38 0.37 1.28e-12 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg14789911 chr21:47582049 C21orf56 -0.42 -6.59 -0.34 1.7e-10 Testicular germ cell tumor; LUSC cis rs2370759 1.000 rs79487858 chr10:32616405 T/C cg01819863 chr10:32635814 EPC1 1.06 13.11 0.58 5.81e-32 Sexual dysfunction (female); LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.33e-19 Menopause (age at onset); LUSC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg09365446 chr1:150670422 GOLPH3L -0.39 -5.75 -0.3 1.99e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg02086790 chr16:375327 AXIN1 -0.4 -6.15 -0.32 2.16e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs7833986 0.941 rs13249175 chr8:57058706 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 9.02 0.44 1.55e-17 Height; LUSC trans rs12286929 0.646 rs12805914 chr11:115019739 T/A cg27361520 chr2:103038171 IL18RAP 0.3 5.97 0.31 6.11e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2742417 1.000 rs2673051 chr3:45732409 G/T cg09608765 chr3:45636137 LIMD1 -0.36 -7.17 -0.37 4.83e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg10802521 chr3:52805072 NEK4 -0.52 -8.33 -0.41 2.19e-15 Bipolar disorder; LUSC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg13854012 chr2:162103682 NA -0.45 -7.97 -0.4 2.58e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg05368731 chr17:41323189 NBR1 0.95 15.89 0.66 9.54e-43 Menopause (age at onset); LUSC cis rs2635047 0.811 rs12956009 chr18:44768024 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.17 0.32 1.96e-9 Educational attainment; LUSC cis rs6121246 0.909 rs6060929 chr20:30345914 C/T cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC trans rs7824557 0.547 rs2736287 chr8:11228006 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.97 -0.36 1.71e-11 Retinal vascular caliber; LUSC cis rs644799 0.562 rs515546 chr11:95588756 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.58 8.81 0.43 6.88e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3126085 0.935 rs10888466 chr1:152166223 A/C cg09127314 chr1:152161683 NA -0.39 -5.65 -0.3 3.42e-8 Atopic dermatitis; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.65 9.75 0.47 6.44e-20 Lymphocyte counts; LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg08677398 chr8:58056175 NA 0.54 6.39 0.33 5.43e-10 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg07424592 chr7:64974309 NA 0.7 6.07 0.32 3.39e-9 Diabetic kidney disease; LUSC cis rs897080 0.515 rs1067325 chr2:44628997 C/T cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs8060686 0.641 rs2418737 chr16:68122726 T/C cg27539214 chr16:67997921 SLC12A4 -0.54 -7.52 -0.38 5.23e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs1577917 0.771 rs2842608 chr6:86295858 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.68 -10.82 -0.51 1.39e-23 Response to antipsychotic treatment; LUSC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg24642844 chr7:1081250 C7orf50 -0.69 -9.49 -0.46 4.43e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.24 0.41 3.87e-15 Bipolar disorder; LUSC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs67460515 0.892 rs13059340 chr3:161062631 T/C cg03342759 chr3:160939853 NMD3 -0.49 -6.84 -0.35 3.9e-11 Parkinson's disease; LUSC cis rs7481584 0.624 rs449466 chr11:3047603 C/T cg25174290 chr11:3078921 CARS -0.41 -6.19 -0.32 1.8e-9 Calcium levels; LUSC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg18876405 chr7:65276391 NA 0.42 5.71 0.3 2.45e-8 Aortic root size; LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs911119 1.000 rs6036478 chr20:23611359 C/A cg16589663 chr20:23618590 CST3 0.59 6.95 0.36 1.88e-11 Chronic kidney disease; LUSC cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.18e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs79349575 0.783 rs832410 chr17:46972865 C/T cg22482690 chr17:47019901 SNF8 0.41 7.56 0.38 4.05e-13 Type 2 diabetes; LUSC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg22800045 chr5:56110881 MAP3K1 0.46 6.39 0.33 5.61e-10 Breast cancer;Breast cancer (early onset); LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg10150615 chr22:24372951 LOC391322 -0.43 -6.76 -0.35 6e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.24 0.52 4.34e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10489202 0.683 rs7515429 chr1:168066659 A/G cg24449463 chr1:168025552 DCAF6 -0.71 -10.61 -0.5 7.27e-23 Schizophrenia; LUSC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs4664304 0.629 rs62175466 chr2:160852308 C/T cg05371993 chr16:1458494 UNKL 0.41 6.01 0.31 4.74e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs977987 0.832 rs37597 chr16:75500275 T/G cg03315344 chr16:75512273 CHST6 -0.5 -9.3 -0.45 1.87e-18 Dupuytren's disease; LUSC cis rs7954584 0.635 rs7313252 chr12:122347600 G/A cg21171335 chr12:122356390 WDR66 0.59 8.79 0.43 8.12e-17 Mean corpuscular volume; LUSC cis rs1577917 0.958 rs12216074 chr6:86520002 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.83 -0.35 4.06e-11 Response to antipsychotic treatment; LUSC trans rs9929218 0.551 rs2274239 chr16:68725783 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.09 25.66 0.81 5.5e-81 Colorectal cancer; LUSC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg23711669 chr6:146136114 FBXO30 0.91 17.28 0.69 3.13e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1065852 0.510 rs5751247 chr22:42633054 T/C cg00645731 chr22:42541494 CYP2D7P1 0.41 7.22 0.37 3.43e-12 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.65 0.39 2.11e-13 Prudent dietary pattern; LUSC cis rs701145 0.585 rs357480 chr3:153891182 A/G cg17054900 chr3:154042577 DHX36 0.71 7.3 0.37 2.16e-12 Coronary artery disease; LUSC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg24675658 chr1:53192096 ZYG11B -0.66 -10.6 -0.5 8.23e-23 Monocyte count; LUSC cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg06552810 chr11:31128660 NA -0.4 -7.08 -0.36 8.78e-12 Red blood cell count; LUSC cis rs7474896 0.609 rs1830612 chr10:37999883 A/G cg25427524 chr10:38739819 LOC399744 -0.49 -6.8 -0.35 4.81e-11 Obesity (extreme); LUSC cis rs4253772 0.530 rs11090875 chr22:46785301 C/T cg00784671 chr22:46762841 CELSR1 -0.59 -6.42 -0.33 4.81e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9420 0.961 rs682503 chr11:57640994 C/G cg02958346 chr11:57425731 CLP1 0.47 6.66 0.34 1.15e-10 Schizophrenia; LUSC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg18357645 chr12:58087776 OS9 0.54 8.38 0.42 1.48e-15 Rheumatoid arthritis; LUSC trans rs7824557 0.564 rs2736290 chr8:11234298 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.74 -0.39 1.21e-13 Retinal vascular caliber; LUSC cis rs4499344 0.622 rs4805767 chr19:33049056 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.77 -9.94 -0.48 1.46e-20 Mean platelet volume; LUSC cis rs1182436 1 rs1182436 chr7:157027753 T/C cg17757837 chr7:157058334 UBE3C -0.55 -6.27 -0.32 1.14e-9 Type 2 diabetes; LUSC cis rs34734847 0.766 rs3794214 chr12:121168245 C/T cg21892295 chr12:121157589 UNC119B 0.33 5.79 0.3 1.65e-8 Mean corpuscular volume; LUSC trans rs11098499 1.000 rs58601355 chr4:120186367 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.44 5.98 0.31 5.61e-9 Corneal astigmatism; LUSC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg10792982 chr14:105748885 BRF1 0.52 9.39 0.46 9.66e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs4662750 0.580 rs4662743 chr2:128350808 A/G cg06107159 chr2:128432243 LIMS2 0.33 5.83 0.3 1.32e-8 Renal cell carcinoma; LUSC cis rs34779708 0.931 rs13377158 chr10:35370465 A/C cg03585969 chr10:35415529 CREM -0.58 -8.59 -0.43 3.39e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg27279351 chr12:120934652 DYNLL1 0.62 8.23 0.41 4.34e-15 High light scatter reticulocyte count; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg20295408 chr7:1910781 MAD1L1 0.49 6.98 0.36 1.63e-11 Bipolar disorder and schizophrenia; LUSC cis rs8017423 0.935 rs4643251 chr14:90669256 C/T cg14092571 chr14:90743983 NA 0.36 5.71 0.3 2.53e-8 Mortality in heart failure; LUSC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg03709012 chr19:19516395 GATAD2A 0.83 14.09 0.61 1.01e-35 Tonsillectomy; LUSC cis rs56283067 0.740 rs111810959 chr6:44709460 C/A cg20913747 chr6:44695427 NA -0.49 -8.22 -0.41 4.6e-15 Total body bone mineral density; LUSC cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.61 9.01 0.44 1.62e-17 Menarche (age at onset); LUSC cis rs62064224 0.702 rs735555 chr17:30817450 A/G cg04830146 chr17:31203787 MYO1D 0.37 5.79 0.3 1.64e-8 Schizophrenia; LUSC cis rs6121246 0.567 rs6060263 chr20:30193110 T/C cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs877282 0.898 rs10904546 chr10:757222 A/G cg17470449 chr10:769945 NA 0.52 6.97 0.36 1.72e-11 Uric acid levels; LUSC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg21643547 chr1:205240462 TMCC2 0.5 9.38 0.46 1.02e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg05855489 chr10:104503620 C10orf26 -0.64 -8.65 -0.43 2.26e-16 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg09267113 chr7:98030324 BAIAP2L1 0.38 5.77 0.3 1.85e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9902453 0.726 rs3115092 chr17:28036350 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.7 0.51 3.49e-23 Coffee consumption (cups per day); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24053619 chr2:61293272 KIAA1841 0.46 6.37 0.33 6.42e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11971779 0.553 rs7799742 chr7:139051878 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs9790314 1.000 rs464766 chr3:161087592 C/G cg04691961 chr3:161091175 C3orf57 -0.35 -6.04 -0.31 4.14e-9 Morning vs. evening chronotype; LUSC cis rs7084921 0.608 rs11597561 chr10:101863041 T/C cg11888571 chr10:102027403 CWF19L1 -0.46 -6.28 -0.32 1.06e-9 Bone mineral density; LUSC cis rs10419226 0.555 rs8100824 chr19:18749412 C/G cg22001208 chr19:18782374 NA -0.39 -6.49 -0.33 3.01e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg18681998 chr4:17616180 MED28 0.8 14.29 0.62 1.69e-36 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs977987 0.806 rs7188231 chr16:75436561 T/C cg03315344 chr16:75512273 CHST6 0.53 10.17 0.49 2.47e-21 Dupuytren's disease; LUSC cis rs13040088 1.000 rs6090155 chr20:61527378 G/A cg23096297 chr20:61557774 DIDO1 0.87 11.49 0.53 5.73e-26 Menopause (age at onset); LUSC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg06637938 chr14:75390232 RPS6KL1 0.54 8.56 0.42 4.04e-16 Height; LUSC cis rs730566 0.640 rs6442112 chr3:48316034 A/G cg21141812 chr3:48556323 PFKFB4 0.31 6.07 0.32 3.38e-9 Prion diseases; LUSC cis rs7829975 0.846 rs6601724 chr8:8544872 C/T cg15556689 chr8:8085844 FLJ10661 -0.61 -9.75 -0.47 6.15e-20 Mood instability; LUSC cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg08999081 chr20:33150536 PIGU -0.4 -7.58 -0.38 3.53e-13 Glomerular filtration rate (creatinine); LUSC cis rs9837602 0.938 rs34922392 chr3:99794730 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.06 -0.31 3.72e-9 Breast cancer; LUSC cis rs6696846 0.740 rs17344537 chr1:205091427 T/G cg03948781 chr1:205179583 DSTYK 0.33 6.32 0.33 8.23e-10 Red blood cell count; LUSC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg19729930 chr2:74357872 NA 0.9 14.8 0.63 1.81e-38 Gestational age at birth (maternal effect); LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.4 0.33 5.4e-10 Menopause (age at onset); LUSC cis rs3750965 0.839 rs921670 chr11:68871639 C/T cg06818126 chr11:68850279 TPCN2 -0.46 -6.73 -0.35 7.23e-11 Hair color; LUSC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg16524733 chr11:117070046 TAGLN -0.44 -7.72 -0.39 1.37e-13 Blood protein levels; LUSC cis rs1348850 0.513 rs6730406 chr2:178492722 C/T cg22681709 chr2:178499509 PDE11A -0.42 -6.79 -0.35 5.04e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.4 -6.52 -0.34 2.58e-10 Longevity;Endometriosis; LUSC cis rs3008870 0.755 rs2815349 chr1:67472280 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.3 0.56 6.39e-29 Lymphocyte percentage of white cells; LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC trans rs9693857 0.518 rs7001721 chr8:9271410 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.1 -0.32 2.9e-9 Systolic blood pressure; LUSC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs4851251 1.000 rs4851251 chr2:100753490 C/T cg07810366 chr2:100720526 AFF3 0.48 7.05 0.36 1.06e-11 Educational attainment (years of education); LUSC cis rs9420 0.961 rs2847308 chr11:57498232 C/T cg23127183 chr11:57508653 C11orf31 0.53 8.17 0.41 6.49e-15 Schizophrenia; LUSC cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg23649088 chr2:200775458 C2orf69 0.58 7.93 0.4 3.31e-14 Schizophrenia; LUSC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg11764359 chr7:65958608 NA 0.69 11.09 0.52 1.48e-24 Aortic root size; LUSC cis rs4654899 0.525 rs12035087 chr1:21471606 T/A cg01072550 chr1:21505969 NA 0.53 8.11 0.41 9.73e-15 Superior frontal gyrus grey matter volume; LUSC cis rs73206853 0.563 rs7301769 chr12:111171026 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.51 0.38 5.32e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.58 0.5 9.15e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg12806067 chr12:132554024 EP400 -0.4 -6.39 -0.33 5.57e-10 N-glycan levels; LUSC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg27165867 chr14:105738592 BRF1 -0.52 -7.49 -0.38 6.12e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs478304 0.651 rs4930313 chr11:65500428 C/T cg27068330 chr11:65405492 SIPA1 -0.76 -10.88 -0.51 8.57e-24 Acne (severe); LUSC trans rs4332037 0.624 rs11764337 chr7:1892309 A/G cg11693508 chr17:37793320 STARD3 -0.5 -6.61 -0.34 1.53e-10 Bipolar disorder; LUSC cis rs9796 0.649 rs8035828 chr15:41467287 T/A cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.5 -0.42 6.62e-16 Menopause (age at onset); LUSC cis rs4654899 0.833 rs10127757 chr1:21490045 A/G cg02927042 chr1:21476669 EIF4G3 -0.39 -6.21 -0.32 1.58e-9 Superior frontal gyrus grey matter volume; LUSC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs1372520 0.748 rs990085 chr4:90754771 A/G cg14346243 chr4:90757452 SNCA -0.4 -5.71 -0.3 2.51e-8 Neuroticism; LUSC cis rs7315438 0.600 rs11067601 chr12:115883429 C/T cg24172291 chr12:115889509 NA 0.34 5.91 0.31 8.22e-9 Colorectal cancer; LUSC cis rs9807841 0.670 rs8113002 chr19:10776606 A/T cg17710535 chr19:10819994 QTRT1 0.43 6.99 0.36 1.49e-11 Inflammatory skin disease; LUSC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg12310025 chr6:25882481 NA -0.42 -6.91 -0.35 2.49e-11 Intelligence (multi-trait analysis); LUSC cis rs12579753 1.000 rs66646148 chr12:82248520 T/G cg21231944 chr12:82153410 PPFIA2 -0.39 -5.94 -0.31 7.3e-9 Resting heart rate; LUSC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4450131 0.522 rs34336231 chr10:126355662 C/T cg20435097 chr10:126320824 FAM53B 0.23 5.86 0.31 1.13e-8 White blood cell count (basophil); LUSC cis rs11030122 0.632 rs714380 chr11:4059653 A/T cg18678763 chr11:4115507 RRM1 -0.5 -6.64 -0.34 1.29e-10 Mean platelet volume;Platelet distribution width; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg19275040 chr1:35325496 C1orf212 0.44 6.42 0.33 4.74e-10 Mosquito bite size; LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -1.01 -15.07 -0.64 1.59e-39 Platelet count; LUSC cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg07274523 chr3:49395745 GPX1 0.66 10.26 0.49 1.18e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs644799 0.544 rs498553 chr11:95534441 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.66 9.63 0.47 1.55e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs8031584 0.918 rs3817498 chr15:31268781 T/C cg08109568 chr15:31115862 NA -0.58 -7.92 -0.4 3.52e-14 Huntington's disease progression; LUSC cis rs8058578 0.943 rs35629860 chr16:30671532 G/A cg02466173 chr16:30829666 NA -0.6 -10.87 -0.51 9.42e-24 Multiple myeloma; LUSC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg11247378 chr22:39784982 NA -0.66 -12.96 -0.58 2.05e-31 Intelligence (multi-trait analysis); LUSC cis rs11169225 0.724 rs7305290 chr12:50341465 A/G cg04450003 chr12:50355995 AQP5 0.6 10.76 0.51 2.21e-23 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg06784218 chr1:46089804 CCDC17 0.5 10.11 0.48 3.73e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4654899 1.000 rs6669102 chr1:21355543 A/G cg01072550 chr1:21505969 NA -0.56 -8.49 -0.42 7.09e-16 Superior frontal gyrus grey matter volume; LUSC cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg21535247 chr6:8435926 SLC35B3 0.58 9.01 0.44 1.59e-17 Motion sickness; LUSC trans rs3733585 0.624 rs58130873 chr4:9972081 T/C cg26043149 chr18:55253948 FECH -0.46 -7.13 -0.36 6.34e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7106204 0.748 rs11827778 chr11:24211321 G/A ch.11.24196551F chr11:24239977 NA 1.13 12.76 0.57 1.21e-30 Response to Homoharringtonine (cytotoxicity); LUSC cis rs500891 0.645 rs12204425 chr6:84162024 G/A cg08257003 chr6:84140564 ME1 0.34 7.66 0.39 1.99e-13 Platelet-derived growth factor BB levels; LUSC cis rs96067 0.805 rs4652902 chr1:36612955 C/A cg24686825 chr1:36642396 MAP7D1 -0.71 -9.67 -0.47 1.18e-19 Corneal structure; LUSC cis rs1003719 0.715 rs9974494 chr21:38566566 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.75e-21 Eye color traits; LUSC cis rs6456156 0.586 rs7761977 chr6:167485678 A/G cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg00321850 chr1:175162397 KIAA0040 0.46 7.83 0.39 6.5e-14 Alcohol dependence; LUSC cis rs7582720 1.000 rs72934745 chr2:203744454 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg11764359 chr7:65958608 NA 0.61 9.27 0.45 2.44e-18 Calcium levels; LUSC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg06640241 chr16:89574553 SPG7 0.88 15.87 0.66 1.12e-42 Multiple myeloma (IgH translocation); LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg08736216 chr1:53307985 ZYG11A -0.28 -5.82 -0.3 1.4e-8 Monocyte count; LUSC cis rs6460942 0.908 rs77894875 chr7:12248257 T/C cg06484146 chr7:12443880 VWDE -0.58 -6.02 -0.31 4.59e-9 Coronary artery disease; LUSC cis rs7072216 0.763 rs7909822 chr10:100172035 A/C cg19567339 chr10:100142640 NA 0.38 5.67 0.3 3.1e-8 Metabolite levels; LUSC trans rs6502050 0.871 rs8072702 chr17:80074280 C/T cg07393940 chr7:158741817 NA -0.37 -6.75 -0.35 6.41e-11 Life satisfaction; LUSC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.62 -13.43 -0.59 3.55e-33 Hemoglobin concentration; LUSC cis rs78545713 0.536 rs2179516 chr6:26229411 C/T cg23601095 chr6:26197514 HIST1H3D 0.64 5.76 0.3 1.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg24531977 chr5:56204891 C5orf35 -0.72 -10.37 -0.49 4.9e-22 Coronary artery disease; LUSC cis rs6424115 0.830 rs2502995 chr1:24199290 T/C cg10978503 chr1:24200527 CNR2 0.54 13.21 0.59 2.32e-32 Immature fraction of reticulocytes; LUSC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.75 -0.39 1.09e-13 Mean platelet volume; LUSC cis rs2806561 0.695 rs67238799 chr1:23335012 G/A cg19743168 chr1:23544995 NA 0.38 7.13 0.36 6.16e-12 Height; LUSC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg03433033 chr1:76189801 ACADM 0.82 14.21 0.61 3.48e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg11764359 chr7:65958608 NA -0.82 -13.78 -0.6 1.69e-34 Aortic root size; LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg08888203 chr3:10149979 C3orf24 0.66 9.31 0.45 1.79e-18 Alzheimer's disease; LUSC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg04865166 chr7:105162814 PUS7 0.53 5.87 0.31 1.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2455601 0.608 rs16906256 chr11:8887097 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -7.6 -0.38 3.1e-13 Schizophrenia; LUSC cis rs12893668 0.703 rs35026580 chr14:104042753 A/G cg04998671 chr14:104000505 TRMT61A -0.48 -6.71 -0.34 8.58e-11 Reticulocyte count; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.75 -0.39 1.13e-13 Lymphocyte counts; LUSC cis rs6541297 1.000 rs11122405 chr1:230282997 C/A cg05784532 chr1:230284198 GALNT2 0.54 8.04 0.4 1.6e-14 Coronary artery disease; LUSC cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg25019033 chr10:957182 NA -0.58 -7.63 -0.39 2.55e-13 Eosinophil percentage of granulocytes; LUSC cis rs7589342 0.792 rs13426321 chr2:106500280 G/A cg14210321 chr2:106509881 NCK2 -0.6 -9.09 -0.45 9.21e-18 Addiction; LUSC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg24578937 chr1:2090814 PRKCZ 0.45 9.95 0.48 1.32e-20 Height; LUSC cis rs1847202 0.826 rs11922892 chr3:72952186 T/G cg25664220 chr3:72788482 NA -0.44 -7.94 -0.4 3.21e-14 Motion sickness; LUSC trans rs61931739 0.500 rs35391785 chr12:34444478 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.81 0.51 1.43e-23 Morning vs. evening chronotype; LUSC cis rs9399401 0.884 rs263181 chr6:142862719 A/G cg03128060 chr6:142623767 GPR126 0.32 5.93 0.31 7.55e-9 Chronic obstructive pulmonary disease; LUSC cis rs924607 1.000 rs924607 chr5:610093 C/T cg09021430 chr5:549028 NA 0.43 7.62 0.38 2.65e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg06481639 chr22:41940642 POLR3H -0.53 -6.19 -0.32 1.77e-9 Vitiligo; LUSC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg11657440 chr19:46296263 DMWD 0.87 16.17 0.66 7.44e-44 Coronary artery disease; LUSC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg07061783 chr6:25882402 NA -0.5 -6.81 -0.35 4.41e-11 Intelligence (multi-trait analysis); LUSC cis rs559928 0.597 rs947939 chr11:63885287 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.26 0.37 2.8e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC trans rs4148689 0.904 rs12533524 chr7:117187461 T/C cg10450175 chr16:88689712 ZC3H18 0.47 6.09 0.32 3.08e-9 Gout; LUSC cis rs9549367 0.789 rs3764124 chr13:113897320 C/T cg00898013 chr13:113819073 PROZ -0.56 -8.48 -0.42 7.34e-16 Platelet distribution width; LUSC cis rs3768617 0.966 rs10797850 chr1:183094802 G/A ch.1.3577855R chr1:183094577 LAMC1 0.61 8.71 0.43 1.44e-16 Fuchs's corneal dystrophy; LUSC cis rs1178968 1.000 rs757938 chr7:72778573 A/G cg25889504 chr7:72793014 NA 0.54 7.03 0.36 1.16e-11 Triglyceride levels; LUSC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.71 0.34 8.59e-11 Schizophrenia; LUSC cis rs2086824 0.702 rs3114891 chr16:89399455 A/G cg02187348 chr16:89574699 SPG7 0.38 5.76 0.3 1.86e-8 Multiple myeloma (IgH translocation); LUSC cis rs4700695 0.764 rs152993 chr5:65262968 A/T cg21114390 chr5:65439923 SFRS12 0.49 5.64 0.3 3.56e-8 Facial morphology (factor 19); LUSC cis rs2721195 1.000 rs1871541 chr8:145681713 G/T cg16383222 chr8:145688536 CYHR1 -0.35 -5.99 -0.31 5.5e-9 Age at first birth; LUSC trans rs6089829 0.962 rs2314130 chr20:61665129 G/T cg15934090 chr1:100435551 SLC35A3 0.48 8.28 0.41 3.05e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs3771570 1.000 rs73002147 chr2:242302934 T/C cg21155796 chr2:242212141 HDLBP 0.62 6.67 0.34 1.07e-10 Prostate cancer; LUSC cis rs7572644 0.664 rs12473340 chr2:28023797 G/A cg27432699 chr2:27873401 GPN1 0.59 7.64 0.39 2.28e-13 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4704187 0.687 rs1582504 chr5:74479545 C/T cg03227963 chr5:74354835 NA 0.3 6.59 0.34 1.68e-10 Response to amphetamines; LUSC trans rs7829975 0.902 rs485107 chr8:8581408 C/G cg21775007 chr8:11205619 TDH -0.43 -6.13 -0.32 2.42e-9 Mood instability; LUSC trans rs877282 0.945 rs11253398 chr10:790012 T/C cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs2573652 1.000 rs2581341 chr15:100514494 T/C cg09918751 chr15:100517450 ADAMTS17 -0.43 -7.88 -0.4 4.54e-14 Height; LUSC cis rs1878931 0.580 rs3848355 chr16:3407489 A/C cg00484396 chr16:3507460 NAT15 -0.37 -6.2 -0.32 1.65e-9 Body mass index (adult); LUSC trans rs656319 0.625 rs34427895 chr8:9875221 G/C cg15556689 chr8:8085844 FLJ10661 -0.48 -6.93 -0.35 2.22e-11 Myopia (pathological); LUSC cis rs6012953 0.967 rs6020585 chr20:49147492 T/C cg13958625 chr20:49123093 NA 0.31 6.73 0.35 7.53e-11 Vitiligo; LUSC cis rs7945718 0.905 rs4454698 chr11:12720560 A/G cg25843174 chr11:12811716 TEAD1 -0.32 -7.03 -0.36 1.2e-11 Educational attainment (years of education); LUSC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg04315214 chr1:2043799 PRKCZ 0.46 9.54 0.46 3.05e-19 Height; LUSC cis rs11718455 0.548 rs9824340 chr3:43902170 A/G cg08738300 chr3:44038990 NA 0.57 8.32 0.41 2.34e-15 Coronary artery disease; LUSC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.44e-10 Extrinsic epigenetic age acceleration; LUSC cis rs10931896 0.531 rs296801 chr2:201142812 C/T cg23649088 chr2:200775458 C2orf69 0.45 7.05 0.36 1.04e-11 Systolic blood pressure; LUSC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg14829155 chr15:31115871 NA -0.57 -7.93 -0.4 3.23e-14 Huntington's disease progression; LUSC cis rs9517320 0.515 rs4772101 chr13:99207554 G/A cg07423050 chr13:99094983 FARP1 -0.53 -9.68 -0.47 1.04e-19 Longevity; LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg10018233 chr7:150070692 REPIN1 0.4 7.28 0.37 2.48e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg23711669 chr6:146136114 FBXO30 0.87 15.5 0.65 3.27e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg06462663 chr19:18546047 ISYNA1 0.46 7.91 0.4 3.7e-14 Breast cancer; LUSC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg09021430 chr5:549028 NA -0.56 -7.62 -0.38 2.66e-13 Obesity-related traits; LUSC cis rs8017423 0.935 rs12880102 chr14:90793526 G/T cg04374321 chr14:90722782 PSMC1 -0.66 -10.01 -0.48 8.62e-21 Mortality in heart failure; LUSC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg09021430 chr5:549028 NA -0.58 -10.06 -0.48 5.56e-21 Obesity-related traits; LUSC cis rs427941 0.632 rs201492 chr7:101754138 C/T cg06246474 chr7:101738831 CUX1 0.39 6.32 0.33 8.19e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs9815354 0.812 rs73079360 chr3:41888372 T/A cg03022575 chr3:42003672 ULK4 0.84 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs17401966 1.000 rs12734068 chr1:10376803 G/A cg19773385 chr1:10388646 KIF1B -0.55 -8.54 -0.42 4.65e-16 Hepatocellular carcinoma; LUSC cis rs6121246 0.529 rs6060118 chr20:30171209 T/C cg13852791 chr20:30311386 BCL2L1 0.7 7.94 0.4 3.17e-14 Mean corpuscular hemoglobin; LUSC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs7903847 0.642 rs10882911 chr10:99138064 A/C cg08345082 chr10:99160200 RRP12 -0.37 -7.56 -0.38 3.89e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs870825 0.860 rs10015194 chr4:185598925 C/T cg04058563 chr4:185651563 MLF1IP 0.84 12.67 0.57 2.58e-30 Blood protein levels; LUSC cis rs7100689 0.725 rs10736340 chr10:82061071 C/T cg00277334 chr10:82204260 NA -0.53 -7.33 -0.37 1.73e-12 Post bronchodilator FEV1; LUSC cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg16586182 chr3:47516702 SCAP -0.51 -8.05 -0.4 1.47e-14 Colorectal cancer; LUSC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg00745463 chr17:30367425 LRRC37B -0.7 -8.52 -0.42 5.45e-16 Hip circumference adjusted for BMI; LUSC cis rs7917772 0.582 rs10786685 chr10:104323103 C/T cg22532475 chr10:104410764 TRIM8 -0.25 -6.13 -0.32 2.43e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.03 0.44 1.37e-17 Motion sickness; LUSC cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg00071950 chr4:10020882 SLC2A9 0.42 6.63 0.34 1.37e-10 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs28374715 0.532 rs28535540 chr15:41659277 G/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -24.1 -0.8 4.7e-75 Ulcerative colitis; LUSC cis rs908922 1.000 rs908922 chr1:152454591 C/T cg20991723 chr1:152506922 NA 0.51 9.21 0.45 3.63e-18 Hair morphology; LUSC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg12639453 chr1:2035780 PRKCZ 0.3 6.4 0.33 5.4e-10 Height; LUSC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg24549020 chr5:56110836 MAP3K1 0.49 5.76 0.3 1.93e-8 Initial pursuit acceleration; LUSC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg18876405 chr7:65276391 NA 0.65 11.32 0.53 2.22e-25 Aortic root size; LUSC cis rs2404602 0.647 rs11631394 chr15:76973209 G/T cg23625390 chr15:77176239 SCAPER -0.65 -10.02 -0.48 7.95e-21 Blood metabolite levels; LUSC cis rs1577917 0.917 rs12202170 chr6:86590386 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.87 -0.35 3.12e-11 Response to antipsychotic treatment; LUSC cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg05294307 chr14:35346193 BAZ1A -0.58 -6.65 -0.34 1.18e-10 Psoriasis; LUSC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg06219351 chr7:158114137 PTPRN2 0.48 8.65 0.43 2.22e-16 Calcium levels; LUSC cis rs7582180 0.629 rs4851308 chr2:100971865 C/A cg08017756 chr2:100939284 LONRF2 -0.47 -8.72 -0.43 1.34e-16 Intelligence (multi-trait analysis); LUSC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg12564285 chr5:131593104 PDLIM4 0.41 8.01 0.4 1.98e-14 Blood metabolite levels; LUSC cis rs7799006 0.862 rs3757439 chr7:2272122 C/T cg02951883 chr7:2050386 MAD1L1 -0.34 -5.81 -0.3 1.45e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs561341 0.883 rs886224 chr17:30229902 T/C cg20587970 chr11:113659929 NA -1.11 -13.48 -0.59 2.22e-33 Hip circumference adjusted for BMI; LUSC cis rs2816062 0.813 rs2816051 chr1:18895460 A/G cg18795169 chr1:18902165 NA -1.01 -24.4 -0.8 3.36e-76 Urate levels in lean individuals; LUSC cis rs72960926 0.744 rs56077244 chr6:74920700 A/G cg03266952 chr6:74778945 NA -0.84 -7.09 -0.36 8.15e-12 Metabolite levels (MHPG); LUSC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg06850241 chr22:41845214 NA 0.31 5.8 0.3 1.56e-8 Vitiligo; LUSC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg07936489 chr17:37558343 FBXL20 0.63 8.2 0.41 5.41e-15 Glomerular filtration rate (creatinine); LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.49 -0.5 1.89e-22 Alzheimer's disease; LUSC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.07 -0.48 5.32e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg15556689 chr8:8085844 FLJ10661 -0.7 -11.5 -0.53 5.06e-26 Joint mobility (Beighton score); LUSC cis rs7709377 0.595 rs173813 chr5:115632671 A/C cg23108291 chr5:115420582 COMMD10 -0.43 -6.11 -0.32 2.83e-9 Metabolite levels (X-11787); LUSC cis rs7267979 1.000 rs12428 chr20:25433821 G/T cg08601574 chr20:25228251 PYGB -0.41 -6.24 -0.32 1.33e-9 Liver enzyme levels (alkaline phosphatase); LUSC trans rs10484761 0.529 rs6914427 chr6:40806615 T/A cg20593826 chr1:59280370 NA 0.44 6.33 0.33 8.08e-10 Esophageal cancer; LUSC cis rs11758351 0.588 rs2050948 chr6:26234952 A/G cg01420254 chr6:26195488 NA 0.65 7.24 0.37 3.03e-12 Gout;Renal underexcretion gout; LUSC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC trans rs4332037 0.539 rs56016347 chr7:2060126 C/T cg11693508 chr17:37793320 STARD3 0.56 6.7 0.34 8.71e-11 Bipolar disorder; LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg08968635 chr6:28129556 ZNF389 0.45 5.67 0.3 3.06e-8 Parkinson's disease; LUSC cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.66e-8 Morning vs. evening chronotype; LUSC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg12463550 chr7:65579703 CRCP 0.42 6.04 0.31 4.08e-9 Aortic root size; LUSC cis rs28374715 0.578 rs72739630 chr15:41631064 G/A cg18705301 chr15:41695430 NDUFAF1 -1.05 -21.18 -0.76 1.05e-63 Ulcerative colitis; LUSC trans rs72674100 1.000 rs28645642 chr4:97971149 C/T cg16405019 chr1:18959625 PAX7 -0.58 -6.31 -0.33 8.97e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12291225 0.679 rs10832240 chr11:14304744 C/T cg05501817 chr11:14380813 RRAS2 -0.57 -9.02 -0.44 1.49e-17 Sense of smell; LUSC cis rs6728642 0.803 rs11891458 chr2:97632450 G/T cg26665480 chr2:98280029 ACTR1B -0.65 -5.77 -0.3 1.76e-8 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs11039100 1.000 rs11039100 chr11:5827003 C/T cg13902645 chr11:5959945 NA 0.53 5.93 0.31 7.62e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.61 -9.62 -0.47 1.67e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3824867 0.879 rs4752837 chr11:47465955 G/A cg20307385 chr11:47447363 PSMC3 0.64 9.48 0.46 4.83e-19 Mean corpuscular hemoglobin; LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs4363385 0.747 rs946098 chr1:152975038 A/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.71 -0.39 1.44e-13 Inflammatory skin disease; LUSC cis rs12701220 0.739 rs2293523 chr7:1098518 G/A cg00990874 chr7:1149470 C7orf50 -0.51 -5.94 -0.31 7.14e-9 Bronchopulmonary dysplasia; LUSC cis rs4851254 0.550 rs13402299 chr2:100659409 C/T cg22139774 chr2:100720529 AFF3 -0.44 -5.75 -0.3 2.06e-8 Intelligence (multi-trait analysis); LUSC cis rs7223966 1.000 rs8078862 chr17:61854068 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.02 0.31 4.67e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs865483 0.895 rs853191 chr17:35821758 A/T cg06716730 chr17:35851459 DUSP14 0.28 6.3 0.33 9.49e-10 Monocyte count; LUSC cis rs7171869 1 rs7171869 chr15:78900909 A/G cg06917634 chr15:78832804 PSMA4 0.52 6.47 0.33 3.58e-10 Post bronchodilator FEV1; LUSC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg04063615 chr12:132293388 NA -0.37 -5.9 -0.31 9.1e-9 Migraine; LUSC cis rs11148252 0.740 rs9536046 chr13:52955899 T/G cg02158880 chr13:53174818 NA 0.38 5.73 0.3 2.25e-8 Lewy body disease; LUSC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg11812906 chr14:75593930 NEK9 0.65 11.13 0.52 1.1e-24 Height; LUSC cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.81e-30 Motion sickness; LUSC cis rs7940866 0.903 rs1347283 chr11:130868583 T/G cg12179176 chr11:130786555 SNX19 0.62 9.55 0.46 2.88e-19 Schizophrenia; LUSC cis rs6750047 0.585 rs4670808 chr2:38267794 A/G cg07380506 chr2:38303506 CYP1B1 0.43 5.95 0.31 6.7e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg18240062 chr17:79603768 NPLOC4 0.58 10.08 0.48 4.95e-21 Eye color traits; LUSC cis rs6120849 0.573 rs3746429 chr20:33703607 A/G cg24642439 chr20:33292090 TP53INP2 -0.55 -5.73 -0.3 2.21e-8 Protein C levels; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.01 0.77 5.62e-67 Prudent dietary pattern; LUSC trans rs6582630 0.519 rs8189618 chr12:38276281 A/C cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.74e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs6500602 0.793 rs4785964 chr16:4484613 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 7.75 0.39 1.12e-13 Schizophrenia; LUSC trans rs2243480 1.000 rs11538349 chr7:65421871 C/T cg10756647 chr7:56101905 PSPH 0.85 8.34 0.42 2.04e-15 Diabetic kidney disease; LUSC cis rs2969070 0.867 rs886626 chr7:2498052 A/C cg03277898 chr7:2518824 NA -0.29 -6.08 -0.32 3.24e-9 Diastolic blood pressure; LUSC trans rs236907 0.814 rs2232825 chr1:171763549 C/T cg13482142 chr2:234261155 NA 0.48 5.98 0.31 5.66e-9 Mean platelet volume; LUSC cis rs3862435 0.764 rs16944453 chr15:90998905 G/A cg22089800 chr15:90895588 ZNF774 0.55 5.78 0.3 1.76e-8 Response to exercise (triglyceride level interaction); LUSC cis rs6967385 0.900 rs10278941 chr7:12364646 G/C cg20607287 chr7:12443886 VWDE 0.4 5.86 0.31 1.09e-8 Response to taxane treatment (placlitaxel); LUSC cis rs7923609 0.967 rs7076310 chr10:65135672 C/A cg01631684 chr10:65280961 REEP3 -0.38 -5.89 -0.31 9.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs7647973 0.593 rs62262730 chr3:49808274 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.61 7.14 0.36 5.81e-12 Menarche (age at onset); LUSC cis rs2486288 0.656 rs12915314 chr15:45551491 C/G cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.67 -0.5 4.42e-23 Glomerular filtration rate; LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg11003573 chr3:44754125 ZNF502 -0.35 -5.68 -0.3 3.01e-8 Depressive symptoms; LUSC cis rs524023 1.000 rs524023 chr11:64358265 C/T cg19131476 chr11:64387923 NRXN2 0.37 9.84 0.47 3.17e-20 Urate levels in obese individuals; LUSC cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC trans rs1223397 0.938 rs35549743 chr6:13294354 C/T cg13974761 chr1:152670598 LCE2A 0.37 6.04 0.31 4.07e-9 Blood pressure; LUSC cis rs7582180 0.739 rs11123824 chr2:100924029 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.44 -0.42 9.64e-16 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg25282410 chr6:160211355 TCP1;MRPL18 1.08 15.25 0.64 3.22e-40 Age-related macular degeneration (geographic atrophy); LUSC cis rs55910451 0.520 rs1858446 chr10:5852172 C/T cg11519256 chr10:5708881 ASB13 0.48 6.06 0.31 3.59e-9 Breast cancer; LUSC cis rs59698941 0.943 rs66628697 chr5:132252561 C/T cg02081065 chr5:132209139 LEAP2 -0.64 -6.66 -0.34 1.1e-10 Apolipoprotein A-IV levels; LUSC cis rs7429990 0.965 rs1550914 chr3:47995168 A/C cg20734569 chr3:48348370 SPINK8 -0.37 -6.26 -0.32 1.2e-9 Educational attainment (years of education); LUSC cis rs9362426 0.672 rs12663865 chr6:88103149 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.35 5.79 0.3 1.65e-8 Depressive episodes in bipolar disorder; LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.33e-19 Menopause (age at onset); LUSC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg16624210 chr5:671434 TPPP 0.49 6.27 0.32 1.12e-9 Obesity-related traits; LUSC cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg22906224 chr7:99728672 NA 0.6 8.76 0.43 1.01e-16 Coronary artery disease; LUSC cis rs2445762 0.518 rs8043240 chr15:51635565 C/T cg07517944 chr15:51633816 GLDN 0.37 6.65 0.34 1.21e-10 Hormone measurements; LUSC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2e-10 Reticulocyte fraction of red cells; LUSC cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg06627628 chr2:24431161 ITSN2 -0.6 -7.34 -0.37 1.69e-12 Lymphocyte counts; LUSC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 8.23 0.41 4.31e-15 Schizophrenia; LUSC cis rs1387259 0.790 rs2732445 chr12:48645533 C/T cg04545296 chr12:48745243 ZNF641 0.34 6.17 0.32 1.98e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs16854884 0.586 rs7650172 chr3:143729408 G/C cg06585982 chr3:143692056 C3orf58 0.53 8.45 0.42 9.21e-16 Economic and political preferences (feminism/equality); LUSC cis rs250677 0.522 rs17109208 chr5:148378475 G/A cg18129178 chr5:148520854 ABLIM3 -0.51 -7.5 -0.38 5.69e-13 Breast cancer; LUSC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22590775 chr19:49891494 CCDC155 0.61 8.79 0.43 8.23e-17 Multiple sclerosis; LUSC cis rs1042058 0.565 rs650110 chr10:30753132 A/G cg25182066 chr10:30743637 MAP3K8 -0.45 -6.69 -0.34 9.58e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2075371 0.611 rs12707154 chr7:134015832 C/T cg11752832 chr7:134001865 SLC35B4 0.51 7.28 0.37 2.36e-12 Mean platelet volume; LUSC cis rs6494488 0.500 rs72741338 chr15:64761087 G/A cg08069370 chr15:64387884 SNX1 -0.65 -5.75 -0.3 2.06e-8 Coronary artery disease; LUSC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg10018233 chr7:150070692 REPIN1 0.38 6.72 0.35 7.85e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs35146811 0.624 rs1727134 chr7:99813672 T/C cg22906224 chr7:99728672 NA -0.49 -6.94 -0.35 2.11e-11 Coronary artery disease; LUSC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg10556349 chr10:835070 NA 0.56 6.65 0.34 1.17e-10 Eosinophil percentage of granulocytes; LUSC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg10556349 chr10:835070 NA 0.56 6.27 0.32 1.09e-9 Eosinophil percentage of granulocytes; LUSC trans rs800082 0.501 rs9878902 chr3:144220319 A/T cg24215973 chr2:240111563 HDAC4 0.49 7.59 0.38 3.24e-13 Smoking behavior; LUSC cis rs16910800 0.731 rs35725172 chr11:23185968 G/A cg20040320 chr11:23191996 NA -0.59 -7.6 -0.38 3.11e-13 Cancer; LUSC cis rs9311676 0.656 rs62258127 chr3:58397102 G/A cg13750441 chr3:58318267 PXK 0.35 6.81 0.35 4.44e-11 Systemic lupus erythematosus; LUSC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg19346786 chr7:2764209 NA -0.4 -7.1 -0.36 7.35e-12 Height; LUSC cis rs1395 0.925 rs2580754 chr2:27398196 A/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.4 6.82 0.35 4.24e-11 Blood metabolite levels; LUSC trans rs1973993 0.745 rs6683508 chr1:96955038 T/C cg10631902 chr5:14652156 NA -0.46 -6.74 -0.35 6.92e-11 Weight; LUSC cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg05855489 chr10:104503620 C10orf26 0.53 8.09 0.4 1.11e-14 Arsenic metabolism; LUSC cis rs6433857 0.536 rs7557023 chr2:181350474 G/A cg23363182 chr2:181467187 NA -0.44 -7.18 -0.37 4.61e-12 Body mass index; LUSC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 10.97 0.51 3.92e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4722166 0.704 rs4321884 chr7:22741459 A/T cg05472934 chr7:22766657 IL6 0.37 5.95 0.31 6.59e-9 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16827057 chr17:73257779 MRPS7;GGA3 -0.43 -6.34 -0.33 7.28e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21784498 chr17:26645922 TMEM97 -0.4 -5.99 -0.31 5.38e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs72960926 0.744 rs72954341 chr6:74947167 A/G cg03266952 chr6:74778945 NA -0.77 -6.77 -0.35 5.96e-11 Metabolite levels (MHPG); LUSC cis rs9300255 0.679 rs10772998 chr12:123721177 T/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.05 -0.31 3.97e-9 Neutrophil percentage of white cells; LUSC cis rs2398893 1.000 rs2398893 chr9:96758342 A/G cg14459158 chr9:96720562 NA 0.32 6.15 0.32 2.24e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2286885 0.965 rs4837091 chr9:129244928 A/G cg15282417 chr9:129245246 FAM125B 0.37 6.13 0.32 2.54e-9 Intraocular pressure; LUSC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg02782426 chr3:40428986 ENTPD3 0.38 6.2 0.32 1.67e-9 Renal cell carcinoma; LUSC trans rs34421088 0.506 rs2409755 chr8:11169983 G/A cg15556689 chr8:8085844 FLJ10661 0.44 6.48 0.33 3.37e-10 Neuroticism; LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg08219700 chr8:58056026 NA 0.7 7.95 0.4 2.95e-14 Developmental language disorder (linguistic errors); LUSC cis rs7089973 0.604 rs11196932 chr10:116584386 C/T cg25233709 chr10:116636983 FAM160B1 0.38 6.63 0.34 1.38e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg20848291 chr7:100343083 ZAN 0.39 6.05 0.31 3.89e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs6736093 0.966 rs34087685 chr2:112693010 G/C cg12686935 chr2:112915763 FBLN7 -0.36 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg16447950 chr5:562315 NA -0.58 -7.11 -0.36 7.26e-12 Obesity-related traits; LUSC cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg23711669 chr6:146136114 FBXO30 0.83 14.71 0.63 4.06e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg26380479 chr7:97908229 NA -0.27 -5.95 -0.31 6.69e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg25319279 chr11:5960081 NA -0.39 -5.81 -0.3 1.42e-8 DNA methylation (variation); LUSC cis rs9527 0.590 rs10883818 chr10:104759586 A/G cg05855489 chr10:104503620 C10orf26 0.52 7.86 0.4 5.22e-14 Arsenic metabolism; LUSC trans rs11722228 0.508 rs2241472 chr4:10085902 C/G cg26043149 chr18:55253948 FECH 0.98 14.62 0.62 9.25e-38 Gout;Urate levels;Serum uric acid levels; LUSC cis rs10992471 0.580 rs12341093 chr9:95234182 G/T cg14631576 chr9:95140430 CENPP -0.34 -6.17 -0.32 1.97e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs3755132 0.852 rs6431718 chr2:15747875 C/T cg12888861 chr2:15731646 DDX1 0.5 7.27 0.37 2.55e-12 Wilms tumor; LUSC cis rs4746818 1.000 rs7091695 chr10:70964997 A/G cg11621586 chr10:70884670 VPS26A -1.12 -11.2 -0.52 6.16e-25 Left atrial antero-posterior diameter; LUSC cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg04450456 chr4:17643702 FAM184B 0.39 6.54 0.34 2.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12195417 0.758 rs6454326 chr6:84115740 A/G cg08257003 chr6:84140564 ME1 0.36 8.88 0.44 4.2e-17 Schizophrenia; LUSC cis rs10782582 0.609 rs1159215 chr1:76317869 A/T cg10523679 chr1:76189770 ACADM -0.46 -6.67 -0.34 1.04e-10 Daytime sleep phenotypes; LUSC cis rs6696846 0.791 rs7520752 chr1:205054114 C/T cg03948781 chr1:205179583 DSTYK -0.32 -6.1 -0.32 2.91e-9 Red blood cell count; LUSC cis rs7615316 0.779 rs2862744 chr3:142105519 C/A cg16271453 chr3:142027066 XRN1 -0.4 -7.11 -0.36 7.04e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7399018 0.739 rs10747608 chr12:51616582 A/G cg25754956 chr12:51612065 POU6F1 0.9 14.4 0.62 6.73e-37 Cisplatin-induced ototoxicity; LUSC cis rs7246967 0.551 rs57775631 chr19:22814461 T/C cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC trans rs11098499 0.909 rs10026736 chr4:120384322 G/C cg25214090 chr10:38739885 LOC399744 0.59 8.52 0.42 5.67e-16 Corneal astigmatism; LUSC cis rs5756813 0.727 rs4821703 chr22:38136676 C/T cg06521852 chr22:38141419 TRIOBP 0.42 6.31 0.33 8.96e-10 Optic cup area;Vertical cup-disc ratio; LUSC trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg03929089 chr4:120376271 NA -0.6 -7.24 -0.37 3.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9646954 0.791 rs4851300 chr2:100958804 C/A cg08017756 chr2:100939284 LONRF2 -0.39 -6.57 -0.34 1.98e-10 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs2273694 chr10:102256496 G/T cg07080220 chr10:102295463 HIF1AN 0.68 9.6 0.47 1.93e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg11494091 chr17:61959527 GH2 0.63 13.39 0.59 4.87e-33 Prudent dietary pattern; LUSC cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.65 0.57 3.1e-30 Motion sickness; LUSC trans rs1997103 1.000 rs4947501 chr7:55407342 C/T cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9640161 0.658 rs60467296 chr7:150015471 G/A cg21361702 chr7:150065534 REPIN1 0.44 5.99 0.31 5.45e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg05294307 chr14:35346193 BAZ1A -0.61 -7.44 -0.38 8.85e-13 Psoriasis; LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg12564285 chr5:131593104 PDLIM4 0.47 8.54 0.42 4.98e-16 Blood metabolite levels; LUSC cis rs2637266 0.507 rs2637250 chr10:78282063 T/C cg18941641 chr10:78392320 NA 0.32 5.96 0.31 6.3e-9 Pulmonary function; LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg25072359 chr17:41440525 NA 0.65 9.28 0.45 2.18e-18 Menopause (age at onset); LUSC cis rs742132 0.527 rs12526321 chr6:25494503 A/G cg03264133 chr6:25882463 NA 0.47 6.49 0.33 3.12e-10 Uric acid levels; LUSC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg01879757 chr17:41196368 BRCA1 -0.46 -7.4 -0.38 1.14e-12 Menopause (age at onset); LUSC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg19901468 chr14:105411992 AHNAK2 -0.71 -12.32 -0.56 5.36e-29 Rheumatoid arthritis; LUSC cis rs453301 0.653 rs7005133 chr8:8901222 T/G cg08975724 chr8:8085496 FLJ10661 0.46 6.53 0.34 2.5e-10 Joint mobility (Beighton score); LUSC cis rs1372520 0.684 rs2583979 chr4:90750588 A/T cg15133208 chr4:90757351 SNCA -0.53 -8.27 -0.41 3.2e-15 Neuroticism; LUSC cis rs9399401 0.667 rs6922607 chr6:142703483 A/G cg03128060 chr6:142623767 GPR126 0.6 9.89 0.48 2.22e-20 Chronic obstructive pulmonary disease; LUSC cis rs13082711 0.595 rs17681498 chr3:27331258 T/C cg02860705 chr3:27208620 NA 0.74 12.38 0.56 3.2e-29 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6690583 0.623 rs2028304 chr1:85488030 G/A cg11262906 chr1:85462892 MCOLN2 -0.66 -6.65 -0.34 1.23e-10 Serum sulfate level; LUSC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg05785598 chr3:49045655 WDR6 0.33 5.84 0.3 1.22e-8 Parkinson's disease; LUSC cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg22906224 chr7:99728672 NA 0.55 8.1 0.41 1.01e-14 Coronary artery disease; LUSC cis rs7605827 0.930 rs7579714 chr2:15686869 A/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs7267979 1.000 rs6050555 chr20:25328543 A/G cg03522245 chr20:25566470 NINL -0.36 -5.73 -0.3 2.21e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg24692254 chr21:30365293 RNF160 0.79 12.95 0.58 2.4e-31 Selective IgA deficiency; LUSC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -9.84 -0.47 3.17e-20 Glomerular filtration rate (creatinine); LUSC trans rs2204008 0.543 rs2387018 chr12:38065638 C/T cg06521331 chr12:34319734 NA -0.4 -6.2 -0.32 1.68e-9 Bladder cancer; LUSC cis rs509477 0.718 rs273346 chr18:32603056 G/T cg23791764 chr18:32556832 MAPRE2 0.4 5.79 0.3 1.65e-8 Cerebrospinal fluid AB1-42 levels; LUSC cis rs10191773 0.535 rs72833432 chr2:113102746 T/C cg07905836 chr2:113190072 RGPD8;RGPD5 0.8 8.83 0.43 6.23e-17 Yeast infection; LUSC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg14552801 chr7:65878734 NA 0.45 6.34 0.33 7.34e-10 Aortic root size; LUSC cis rs9831754 0.906 rs9869812 chr3:78385679 G/A cg06138941 chr3:78371609 NA -0.66 -8.99 -0.44 1.87e-17 Calcium levels; LUSC cis rs7746199 0.736 rs34573979 chr6:27480526 C/T cg09904177 chr6:26538194 HMGN4 -0.76 -5.96 -0.31 6.44e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03959472 chr4:170191358 SH3RF1 -0.44 -5.96 -0.31 6.49e-9 Hepatitis; LUSC cis rs433852 0.718 rs550455 chr19:49136515 A/G cg06530960 chr19:49140787 SEC1;DBP -0.55 -7.52 -0.38 5.14e-13 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg08754478 chr10:133766260 PPP2R2D -0.61 -7.65 -0.39 2.17e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs6009527 1.000 rs2318942 chr22:49573505 G/A cg12746016 chr22:49560550 NA 0.37 6.24 0.32 1.3e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs73591976 0.539 rs12446198 chr16:68125972 G/A cg04539111 chr16:67997858 SLC12A4 -0.45 -5.92 -0.31 7.92e-9 HDL cholesterol; LUSC cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.56 0.38 3.9e-13 Colorectal cancer; LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg04944784 chr2:26401820 FAM59B 0.76 11.15 0.52 9.4e-25 Gut microbiome composition (summer); LUSC cis rs7621025 0.500 rs4678275 chr3:136653683 C/T cg15507776 chr3:136538369 TMEM22 0.59 8.34 0.42 1.99e-15 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs7267979 1.000 rs448396 chr20:25440269 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg07959070 chr22:50026188 C22orf34 -0.34 -6.81 -0.35 4.57e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.81 -0.3 1.45e-8 Vitiligo; LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.45 0.53 8.13e-26 Prudent dietary pattern; LUSC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg09491104 chr22:46646882 C22orf40 -0.7 -7.38 -0.37 1.28e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg04315214 chr1:2043799 PRKCZ -0.39 -7.74 -0.39 1.18e-13 Height; LUSC cis rs6541297 1.000 rs4846909 chr1:230285372 G/A cg20703242 chr1:230279135 GALNT2 0.55 8.6 0.43 3.24e-16 Coronary artery disease; LUSC cis rs6961069 0.503 rs3211834 chr7:80280117 A/C cg04458919 chr7:80252533 CD36 0.39 6.66 0.34 1.11e-10 Platelet count; LUSC cis rs7582180 0.591 rs12991577 chr2:101010867 C/A cg12002119 chr2:101014098 CHST10 0.36 6.06 0.31 3.77e-9 Intelligence (multi-trait analysis); LUSC cis rs17095355 1.000 rs12571872 chr10:111676114 G/A cg00817464 chr10:111662876 XPNPEP1 -0.64 -7.47 -0.38 6.94e-13 Biliary atresia; LUSC cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg04990556 chr1:26633338 UBXN11 -0.45 -6.05 -0.31 3.93e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs983392 0.679 rs636317 chr11:60019150 C/T cg20284999 chr11:59952153 MS4A6A 0.4 6.87 0.35 3.22e-11 Alzheimer's disease (late onset); LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.83 -0.35 4.1e-11 Lung cancer; LUSC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg26408565 chr15:76604113 ETFA -0.48 -7.49 -0.38 6.26e-13 Blood metabolite levels; LUSC cis rs73206853 0.841 rs73191840 chr12:110970457 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs3540 0.597 rs1978151 chr15:91037300 C/T cg22089800 chr15:90895588 ZNF774 0.65 9.74 0.47 6.63e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs317865 0.748 rs73234656 chr4:16212702 G/A cg04764131 chr4:16228633 TAPT1;FLJ39653 0.6 5.76 0.3 1.94e-8 Kidney disease (early stage) in type 1 diabetes; LUSC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg24250549 chr1:154909240 PMVK 0.64 10.4 0.49 3.92e-22 Prostate cancer; LUSC cis rs478304 0.654 rs6591185 chr11:65455742 A/G cg05805236 chr11:65401703 PCNXL3 -0.63 -10.33 -0.49 6.71e-22 Acne (severe); LUSC cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg16230307 chr14:35515116 FAM177A1 0.81 10.21 0.49 1.73e-21 Psoriasis; LUSC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -6.47 -0.33 3.46e-10 Schizophrenia; LUSC cis rs1865721 0.771 rs7235563 chr18:73139335 C/G cg26385618 chr18:73139727 C18orf62 -0.51 -8.93 -0.44 2.96e-17 Intelligence; LUSC cis rs7615316 0.751 rs57177110 chr3:142139172 T/C cg16271453 chr3:142027066 XRN1 -0.43 -7.46 -0.38 7.63e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg18225595 chr11:63971243 STIP1 0.63 10.13 0.48 3.22e-21 Platelet count; LUSC cis rs908922 0.651 rs1337341 chr1:152508259 A/C cg20991723 chr1:152506922 NA 0.52 9.91 0.48 1.86e-20 Hair morphology; LUSC cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg16586182 chr3:47516702 SCAP 0.52 7.96 0.4 2.63e-14 Colorectal cancer; LUSC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg09021430 chr5:549028 NA -0.49 -6.93 -0.35 2.23e-11 Obesity-related traits; LUSC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg13206674 chr6:150067644 NUP43 0.58 9.08 0.45 9.37e-18 Lung cancer; LUSC cis rs4664308 1.000 rs6707458 chr2:160914540 G/T cg03641300 chr2:160917029 PLA2R1 -0.63 -10.68 -0.5 4.21e-23 Idiopathic membranous nephropathy; LUSC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg13319975 chr6:146136371 FBXO30 -0.51 -7.74 -0.39 1.21e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9462027 0.585 rs2814976 chr6:34576237 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.52e-9 Systemic lupus erythematosus; LUSC cis rs7527798 0.592 rs11118282 chr1:207832402 G/A cg09232269 chr1:207846808 CR1L -0.29 -6.21 -0.32 1.61e-9 Erythrocyte sedimentation rate; LUSC trans rs637571 0.522 rs493899 chr11:65747952 A/C cg17712092 chr4:129076599 LARP1B 0.73 11.13 0.52 1.14e-24 Eosinophil percentage of white cells; LUSC cis rs599083 0.793 rs471966 chr11:68173861 C/T cg20283391 chr11:68216788 NA 0.48 6.53 0.34 2.39e-10 Bone mineral density (spine); LUSC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC cis rs950169 0.922 rs17531523 chr15:85132449 C/G cg11189052 chr15:85197271 WDR73 0.48 5.87 0.31 1.04e-8 Schizophrenia; LUSC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg24250549 chr1:154909240 PMVK 0.62 10.02 0.48 7.91e-21 Prostate cancer; LUSC cis rs6665290 0.904 rs6664955 chr1:227183434 T/C cg10327440 chr1:227177885 CDC42BPA -1.21 -39.71 -0.91 1.49e-128 Myeloid white cell count; LUSC cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.21 29.12 0.85 1.14e-93 Chronic sinus infection; LUSC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg05623727 chr3:50126028 RBM5 -0.34 -6.54 -0.34 2.26e-10 Body mass index; LUSC cis rs2932538 0.922 rs6668533 chr1:113064468 C/T cg22162597 chr1:113214053 CAPZA1 0.7 9.76 0.47 5.68e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg05347473 chr6:146136440 FBXO30 0.53 9.01 0.44 1.61e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs12973672 0.904 rs12974791 chr19:35767218 A/G cg12095397 chr19:35769544 USF2 0.44 6.92 0.35 2.37e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg16606324 chr3:10149918 C3orf24 -0.58 -8.47 -0.42 7.82e-16 Alzheimer's disease; LUSC cis rs4629710 0.592 rs4424112 chr6:131563788 C/T cg12700074 chr6:131571435 AKAP7 -0.35 -5.76 -0.3 1.91e-8 Multiple myeloma (IgH translocation); LUSC cis rs1790761 0.632 rs625978 chr11:67344664 C/T cg00290607 chr11:67383545 NA 0.37 6.93 0.35 2.22e-11 Mean corpuscular volume; LUSC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2324229 0.754 rs1180234 chr6:83948473 G/T cg08257003 chr6:84140564 ME1 0.28 6.78 0.35 5.51e-11 Platelet-derived growth factor BB levels; LUSC cis rs790123 1.000 rs2650950 chr3:122382048 C/T cg17380795 chr3:122379686 NA 0.35 5.74 0.3 2.15e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs1448094 0.967 rs7312144 chr12:86328256 T/C cg00310523 chr12:86230176 RASSF9 0.4 7.33 0.37 1.8e-12 Major depressive disorder; LUSC cis rs9814567 1.000 rs1880376 chr3:134270347 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs55720021 1 rs55720021 chr19:49144241 G/T cg06530960 chr19:49140787 SEC1;DBP 0.5 6.67 0.34 1.09e-10 Lymphocyte percentage of white cells;Neutrophil percentage of white cells; LUSC cis rs9486719 0.947 rs2499801 chr6:96854594 G/A cg06623918 chr6:96969491 KIAA0776 0.77 9.22 0.45 3.56e-18 Migraine;Coronary artery disease; LUSC cis rs9287719 0.967 rs6432121 chr2:10753804 G/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 3e-9 Prostate cancer; LUSC cis rs12579753 0.913 rs12579018 chr12:82231943 T/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg25061697 chr4:841865 NA -0.39 -6.02 -0.31 4.67e-9 Bladder cancer; LUSC cis rs1215050 0.904 rs1727285 chr4:98978821 G/A cg05340658 chr4:99064831 C4orf37 -0.43 -6.57 -0.34 1.96e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs354225 0.584 rs13432302 chr2:54813938 A/C cg26097391 chr2:54893211 SPTBN1 0.44 6.6 0.34 1.6e-10 Schizophrenia; LUSC cis rs34311866 0.808 rs4583705 chr4:973036 C/T cg14530993 chr4:882597 GAK 0.66 6.7 0.34 9.12e-11 Parkinson's disease; LUSC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg04414720 chr1:150670196 GOLPH3L -0.48 -7.57 -0.38 3.74e-13 Tonsillectomy; LUSC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg25456477 chr12:86230367 RASSF9 -0.35 -6.18 -0.32 1.9e-9 Major depressive disorder; LUSC cis rs7178572 0.889 rs7177055 chr15:77832762 A/G cg22256960 chr15:77711686 NA 0.5 8.39 0.42 1.41e-15 Type 2 diabetes; LUSC cis rs11626933 1.000 rs59905513 chr14:90749638 T/C cg14092571 chr14:90743983 NA -0.89 -18.66 -0.71 9.62e-54 Gut microbiota (bacterial taxa); LUSC cis rs6754311 0.509 rs10188066 chr2:136539513 G/A cg07169764 chr2:136633963 MCM6 -0.73 -9.86 -0.47 2.64e-20 Mosquito bite size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17964432 chr4:184020264 WWC2;C4orf38 -0.41 -6.39 -0.33 5.5e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1322512 0.622 rs2758796 chr6:152931766 G/A cg27316956 chr6:152958899 SYNE1 -0.35 -5.85 -0.31 1.15e-8 Tonometry; LUSC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg09655341 chr17:79618100 PDE6G -0.28 -6.58 -0.34 1.81e-10 Eye color traits; LUSC trans rs2243480 0.803 rs34004500 chr7:65312178 A/T cg10756647 chr7:56101905 PSPH 0.87 8.43 0.42 1.06e-15 Diabetic kidney disease; LUSC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg13206674 chr6:150067644 NUP43 0.57 9.09 0.45 9.1e-18 Lung cancer; LUSC trans rs61931739 0.513 rs4931760 chr12:33898361 T/C cg13010199 chr12:38710504 ALG10B 0.46 7.07 0.36 9.06e-12 Morning vs. evening chronotype; LUSC cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg23750338 chr8:142222470 SLC45A4 -0.55 -10.59 -0.5 8.48e-23 Immature fraction of reticulocytes; LUSC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg00310523 chr12:86230176 RASSF9 0.53 10.25 0.49 1.28e-21 Major depressive disorder; LUSC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg22508957 chr16:3507546 NAT15 0.64 10.65 0.5 5.48e-23 Tuberculosis; LUSC cis rs7178572 0.849 rs1005752 chr15:77818128 C/A cg22256960 chr15:77711686 NA -0.51 -8.42 -0.42 1.16e-15 Type 2 diabetes; LUSC cis rs11247915 1.000 rs11247915 chr1:26650550 G/T cg15628303 chr1:26608928 UBXN11 -0.35 -6.28 -0.33 1.03e-9 Obesity-related traits; LUSC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg27532560 chr4:187881888 NA -0.43 -6.95 -0.36 1.87e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -8.62 -0.43 2.79e-16 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg08736216 chr1:53307985 ZYG11A -0.27 -5.79 -0.3 1.6e-8 Monocyte count; LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg01579765 chr21:45077557 HSF2BP -0.52 -10.97 -0.51 3.99e-24 Mean corpuscular volume; LUSC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg14019146 chr3:50243930 SLC38A3 0.29 6.42 0.33 4.79e-10 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21488398 chr2:70369791 NA -0.41 -6.48 -0.33 3.3e-10 Electrocardiographic conduction measures; LUSC cis rs11971779 0.680 rs9683 chr7:139107739 T/A cg07862535 chr7:139043722 LUC7L2 0.57 7.23 0.37 3.26e-12 Diisocyanate-induced asthma; LUSC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs738322 0.839 rs133015 chr22:38572526 C/G cg17652424 chr22:38574118 PLA2G6 -0.29 -6.2 -0.32 1.69e-9 Cutaneous nevi; LUSC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg08280861 chr8:58055591 NA 0.54 5.94 0.31 6.98e-9 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg06850241 chr22:41845214 NA 0.32 5.83 0.3 1.28e-8 Vitiligo; LUSC cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.91 0.4 3.71e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs34779708 0.733 rs12254018 chr10:35550641 T/A cg03585969 chr10:35415529 CREM 0.53 7.37 0.37 1.32e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7589342 0.669 rs11895604 chr2:106536134 G/A cg14210321 chr2:106509881 NCK2 -0.56 -8.55 -0.42 4.44e-16 Addiction; LUSC trans rs1994135 0.669 rs10844628 chr12:33697065 T/C cg26384229 chr12:38710491 ALG10B 0.62 8.6 0.43 3.05e-16 Resting heart rate; LUSC cis rs9300255 0.602 rs1716168 chr12:123651966 C/G cg05973401 chr12:123451056 ABCB9 -0.54 -6.72 -0.34 8.09e-11 Neutrophil percentage of white cells; LUSC trans rs12310956 0.510 rs2054867 chr12:33835462 C/G cg26384229 chr12:38710491 ALG10B -0.56 -8.93 -0.44 2.97e-17 Morning vs. evening chronotype; LUSC trans rs61931739 0.890 rs694706 chr12:34135323 T/C cg26384229 chr12:38710491 ALG10B 0.57 9.05 0.44 1.24e-17 Morning vs. evening chronotype; LUSC cis rs3820928 1.000 rs3820928 chr2:227773466 A/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.78 -0.39 8.85e-14 Pulmonary function; LUSC cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14240646 chr10:27532245 ACBD5 0.7 8.12 0.41 9.18e-15 Breast cancer; LUSC cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg13319975 chr6:146136371 FBXO30 -0.48 -6.99 -0.36 1.49e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs870825 0.616 rs1401358 chr4:185640057 C/T cg04058563 chr4:185651563 MLF1IP 0.87 14.74 0.63 3.05e-38 Blood protein levels; LUSC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg18357526 chr6:26021779 HIST1H4A 0.43 6.7 0.34 8.69e-11 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg20503657 chr10:835505 NA 0.78 9.42 0.46 7.61e-19 Eosinophil percentage of granulocytes; LUSC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2273669 0.667 rs17070139 chr6:109358345 C/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 9.1e-9 Prostate cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03657485 chr18:12702964 PSMG2;CEP76 -0.4 -6.08 -0.32 3.32e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg08847533 chr14:75593920 NEK9 0.85 15.84 0.65 1.54e-42 Height; LUSC cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.64 -0.34 1.28e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.2e-9 Menopause (age at onset); LUSC cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg05294307 chr14:35346193 BAZ1A -0.61 -7.4 -0.38 1.15e-12 Psoriasis; LUSC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -10.11 -0.48 3.96e-21 Glomerular filtration rate (creatinine); LUSC cis rs243505 0.762 rs10241408 chr7:148481488 G/A cg09806900 chr7:148480153 CUL1 0.59 8.68 0.43 1.72e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs34779708 0.931 rs4934720 chr10:35376800 T/C cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.52e-37 Gout; LUSC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg26441486 chr22:50317300 CRELD2 0.49 6.78 0.35 5.54e-11 Schizophrenia; LUSC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg02609749 chr16:89786786 C16orf7;ZNF276 0.48 8.05 0.4 1.46e-14 Vitiligo; LUSC cis rs9467773 0.595 rs2451736 chr6:26620544 G/A cg11502198 chr6:26597334 ABT1 0.7 11.83 0.54 3.39e-27 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6740322 0.895 rs10196095 chr2:43571885 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.49 -6.81 -0.35 4.41e-11 Coronary artery disease; LUSC cis rs11098499 0.789 rs12498994 chr4:120250818 A/C cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs6840360 0.967 rs1511170 chr4:152701110 A/G cg22705602 chr4:152727874 NA -0.27 -5.74 -0.3 2.11e-8 Intelligence (multi-trait analysis); LUSC cis rs977987 0.778 rs4888413 chr16:75443223 C/A cg03315344 chr16:75512273 CHST6 0.48 8.98 0.44 2.08e-17 Dupuytren's disease; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg24846343 chr22:24311635 DDTL -0.57 -12.28 -0.56 7.65e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9790314 1.000 rs336591 chr3:161078080 A/G cg04691961 chr3:161091175 C3orf57 -0.36 -6.24 -0.32 1.34e-9 Morning vs. evening chronotype; LUSC cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg16049864 chr8:95962084 TP53INP1 -0.66 -12.3 -0.56 6.3e-29 Type 2 diabetes; LUSC cis rs7100689 0.646 rs9804236 chr10:82135100 T/C cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.5 -0.46 4.07e-19 Schizophrenia; LUSC cis rs1564271 0.553 rs1616702 chr10:26989529 G/C cg13837822 chr10:26931731 LOC731789 0.47 9.93 0.48 1.55e-20 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs968451 0.865 rs12627970 chr22:39721745 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.65 8.36 0.42 1.69e-15 Primary biliary cholangitis; LUSC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg24675658 chr1:53192096 ZYG11B 0.75 12.9 0.58 3.69e-31 Monocyte count; LUSC cis rs7582180 0.585 rs12999151 chr2:100939333 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis); LUSC trans rs78049276 0.736 rs6842241 chr4:148400819 C/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.54 -6.12 -0.32 2.68e-9 Pulse pressure; LUSC cis rs4588572 0.643 rs6453391 chr5:77755035 T/C cg11547950 chr5:77652471 NA -0.56 -7.9 -0.4 4.04e-14 Triglycerides; LUSC cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.76 -0.51 2.13e-23 Alzheimer's disease (late onset); LUSC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg04414720 chr1:150670196 GOLPH3L 0.53 8.5 0.42 6.19e-16 Tonsillectomy; LUSC cis rs6582630 0.576 rs4882375 chr12:38371939 G/T cg13010199 chr12:38710504 ALG10B -0.44 -6.69 -0.34 9.49e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg12658694 chr1:38397304 INPP5B 0.43 6.42 0.33 4.65e-10 Coronary artery disease; LUSC cis rs7119 0.717 rs11636529 chr15:77816220 T/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.56 -8.72 -0.43 1.33e-16 Lymphocyte counts; LUSC cis rs13315871 1.000 rs9821570 chr3:58335919 C/G cg20936604 chr3:58311152 NA -0.73 -7.37 -0.37 1.31e-12 Cholesterol, total; LUSC cis rs17270561 0.609 rs9358886 chr6:25758253 T/A cg16482183 chr6:26056742 HIST1H1C 0.64 8.64 0.43 2.41e-16 Iron status biomarkers; LUSC cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg09184832 chr6:79620586 NA -0.45 -7.29 -0.37 2.27e-12 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.844 rs6132824 chr20:25238173 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.69 13.08 0.58 7.62e-32 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg06238570 chr21:40685208 BRWD1 -0.64 -10.63 -0.5 6.19e-23 Cognitive function; LUSC cis rs4988958 0.527 rs11465641 chr2:103000868 T/G cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.27e-12 Asthma (childhood onset); LUSC cis rs4363385 0.818 rs10788854 chr1:153002320 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.09 -0.36 8.12e-12 Inflammatory skin disease; LUSC cis rs9549367 0.756 rs2302756 chr13:113900197 G/A cg18105134 chr13:113819100 PROZ 0.64 9.14 0.45 6.1e-18 Platelet distribution width; LUSC cis rs1348850 0.645 rs10164417 chr2:178444130 A/G cg23306229 chr2:178417860 TTC30B 0.51 5.8 0.3 1.53e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11098499 0.954 rs13133522 chr4:120324424 A/T cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC trans rs7647973 0.710 rs2029591 chr3:49646981 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.28 0.37 2.43e-12 Menarche (age at onset); LUSC cis rs6964587 1.000 rs6969981 chr7:91689461 G/C cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.58 -7.86 -0.4 5.33e-14 Mean platelet volume; LUSC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg15848620 chr12:58087721 OS9 0.46 5.73 0.3 2.26e-8 Multiple sclerosis; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg07362569 chr17:61921086 SMARCD2 0.37 7.41 0.38 1.07e-12 Prudent dietary pattern; LUSC cis rs2742234 0.590 rs741968 chr10:43611708 A/G cg15436174 chr10:43711423 RASGEF1A -0.45 -7.47 -0.38 6.96e-13 Hirschsprung disease; LUSC cis rs1790761 0.967 rs13859 chr11:67202156 C/T cg24690094 chr11:67383802 NA -0.33 -6.06 -0.31 3.62e-9 Mean corpuscular volume; LUSC cis rs7586879 0.828 rs12986610 chr2:25106265 A/G cg04586622 chr2:25135609 ADCY3 -0.31 -5.97 -0.31 6.2e-9 Body mass index; LUSC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg11247378 chr22:39784982 NA -0.56 -8.67 -0.43 1.89e-16 IgG glycosylation; LUSC cis rs6665290 0.904 rs3795451 chr1:227181923 C/T cg10327440 chr1:227177885 CDC42BPA -1.22 -40.24 -0.91 3.88e-130 Myeloid white cell count; LUSC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg21963583 chr11:68658836 MRPL21 0.56 8.37 0.42 1.58e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9733 0.650 rs12125672 chr1:150554470 A/T cg13175981 chr1:150552382 MCL1 0.53 7.4 0.38 1.09e-12 Tonsillectomy; LUSC cis rs1371867 0.875 rs7830342 chr8:101327738 T/A cg00191853 chr8:101177733 SPAG1 -0.38 -6.36 -0.33 6.71e-10 Atrioventricular conduction; LUSC cis rs10911251 0.528 rs2182020 chr1:183074964 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.81 0.51 1.45e-23 Colorectal cancer; LUSC cis rs1577917 0.518 rs2475787 chr6:86415236 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.41 6.54 0.34 2.24e-10 Response to antipsychotic treatment; LUSC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.41 0.33 4.97e-10 Schizophrenia; LUSC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg19774624 chr17:42201019 HDAC5 -0.81 -12.77 -0.57 1.1e-30 Total body bone mineral density; LUSC cis rs968567 0.705 rs174572 chr11:61598288 C/T cg06781209 chr11:61594997 FADS2 -0.42 -6.78 -0.35 5.41e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC trans rs57221529 0.766 rs12519763 chr5:559145 C/T cg11887960 chr12:57824829 NA 0.55 7.21 0.37 3.7e-12 Lung disease severity in cystic fibrosis; LUSC trans rs17685 0.890 rs76021834 chr7:75607155 A/G cg19862616 chr7:65841803 NCRNA00174 0.79 11.25 0.52 4.18e-25 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs9815354 0.680 rs73073262 chr3:42018443 G/T cg03022575 chr3:42003672 ULK4 0.76 7.59 0.38 3.33e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs10733682 0.633 rs869500 chr9:129465898 G/A cg00232160 chr9:129468157 NA 0.43 7.71 0.39 1.45e-13 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.11 0.36 7.01e-12 Colorectal cancer; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg11494091 chr17:61959527 GH2 0.63 13.44 0.59 3.14e-33 Prudent dietary pattern; LUSC cis rs8050260 0.500 rs4783650 chr16:68558528 T/C cg02972257 chr16:68554789 NA 0.56 6.97 0.36 1.73e-11 Plateletcrit; LUSC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.17 0.41 6.43e-15 Melanoma; LUSC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg05585544 chr11:47624801 NA -0.42 -7.26 -0.37 2.71e-12 Subjective well-being; LUSC cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.24 -0.37 3.2e-12 Menopause (age at onset); LUSC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg15145296 chr3:125709740 NA -0.58 -6.52 -0.34 2.67e-10 Blood pressure (smoking interaction); LUSC cis rs6580649 0.941 rs12580764 chr12:48453882 G/A cg24011408 chr12:48396354 COL2A1 -0.46 -6.12 -0.32 2.56e-9 Lung cancer; LUSC cis rs4474465 1.000 rs10899520 chr11:78183370 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg04287289 chr16:89883240 FANCA -0.41 -5.99 -0.31 5.48e-9 Vitiligo; LUSC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg22823121 chr1:150693482 HORMAD1 -0.46 -7.06 -0.36 9.57e-12 Tonsillectomy; LUSC trans rs4650994 0.544 rs2811314 chr1:178619183 C/T cg05059571 chr16:84539110 KIAA1609 0.46 8.67 0.43 1.87e-16 HDL cholesterol levels;HDL cholesterol; LUSC cis rs9660992 0.736 rs55673946 chr1:205250475 T/C cg00857998 chr1:205179979 DSTYK 0.52 7.83 0.39 6.47e-14 Mean corpuscular volume;Mean platelet volume; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg00610228 chr6:35695934 FKBP5;LOC285847 0.48 6.02 0.31 4.55e-9 Cognitive function;Information processing speed; LUSC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.16 0.36 5.16e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2637266 1.000 rs10824425 chr10:78340310 C/G cg18941641 chr10:78392320 NA 0.38 7.11 0.36 7.08e-12 Pulmonary function; LUSC cis rs9311676 0.609 rs6770113 chr3:58379297 C/A cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.66 11.47 0.53 6.88e-26 Menarche (age at onset); LUSC cis rs2760061 0.626 rs591582 chr1:228117360 C/A cg18477163 chr1:228402036 OBSCN -0.56 -10.49 -0.5 1.95e-22 Diastolic blood pressure; LUSC cis rs6541297 1.000 rs4846839 chr1:230284924 A/G cg05784532 chr1:230284198 GALNT2 0.55 8.18 0.41 6.09e-15 Coronary artery disease; LUSC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg16339924 chr4:17578868 LAP3 0.62 9.19 0.45 4.41e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg04450456 chr4:17643702 FAM184B 0.41 7.14 0.36 5.9e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6952808 0.543 rs4719436 chr7:2141239 G/A cg04565464 chr8:145669602 NFKBIL2 0.37 6.07 0.32 3.44e-9 Bipolar disorder and schizophrenia; LUSC cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg15541040 chr2:3486749 NA -0.58 -8.92 -0.44 3.07e-17 Neurofibrillary tangles; LUSC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.13 0.41 8.21e-15 Homoarginine levels; LUSC cis rs11112613 0.713 rs10507192 chr12:105948247 A/G cg03607813 chr12:105948248 NA 0.82 12.24 0.56 1.04e-28 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs6835098 0.887 rs12644699 chr4:174142874 A/G cg08422745 chr4:174089978 GALNT7 0.71 11.34 0.53 2.02e-25 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.84 0.39 6.15e-14 Prudent dietary pattern; LUSC trans rs7181230 0.885 rs8026641 chr15:40338861 C/T cg22705835 chr10:65332833 REEP3 0.36 5.99 0.31 5.36e-9 Dehydroepiandrosterone sulphate levels; LUSC cis rs12908161 1.000 rs12911736 chr15:85240008 A/G cg12863693 chr15:85201151 NMB 0.42 8.65 0.43 2.14e-16 Schizophrenia; LUSC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg06618935 chr21:46677482 NA -0.36 -6.98 -0.36 1.55e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs208520 1.000 rs12209225 chr6:66996443 G/T cg07460842 chr6:66804631 NA 0.93 12.22 0.56 1.2e-28 Exhaled nitric oxide output; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.5 6.13 0.32 2.43e-9 Renal function-related traits (BUN); LUSC cis rs950169 0.580 rs1061737 chr15:85183790 G/C cg11189052 chr15:85197271 WDR73 0.5 6.39 0.33 5.56e-10 Schizophrenia; LUSC cis rs147499554 1 rs147499554 chr15:78900650 C/T cg06917634 chr15:78832804 PSMA4 -0.44 -5.91 -0.31 8.24e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs147649347 1 rs147649347 chr2:24210076 GATAA/G cg20701182 chr2:24300061 SF3B14 0.74 7.48 0.38 6.68e-13 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg03676636 chr4:99064102 C4orf37 0.38 7.91 0.4 3.85e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6977660 0.714 rs10276518 chr7:19781325 C/A cg05791153 chr7:19748676 TWISTNB 0.76 7.51 0.38 5.62e-13 Thyroid stimulating hormone; LUSC cis rs7927771 0.524 rs11039415 chr11:47845814 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.52 0.34 2.68e-10 Subjective well-being; LUSC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg20203395 chr5:56204925 C5orf35 -0.56 -7.89 -0.4 4.42e-14 Type 2 diabetes; LUSC cis rs3106136 0.967 rs11722476 chr4:95170839 G/A cg11021082 chr4:95130006 SMARCAD1 -0.36 -6.32 -0.33 8.39e-10 Capecitabine sensitivity; LUSC cis rs7945718 0.934 rs3993110 chr11:12794530 A/C cg25843174 chr11:12811716 TEAD1 0.34 7.58 0.38 3.5e-13 Educational attainment (years of education); LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 12.96 0.58 2.16e-31 Platelet count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24686684 chr20:48330546 B4GALT5 -0.52 -6.26 -0.32 1.21e-9 Bipolar disorder and schizophrenia; LUSC cis rs9815354 0.904 rs9852991 chr3:41875455 C/A cg03022575 chr3:42003672 ULK4 0.64 7.02 0.36 1.21e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs2290159 0.752 rs5746182 chr3:12672550 A/G cg23032965 chr3:12705835 RAF1 0.74 9.13 0.45 6.87e-18 Cholesterol, total; LUSC cis rs6912958 0.500 rs3828759 chr6:87806640 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.44 -8.04 -0.4 1.54e-14 Monocyte percentage of white cells; LUSC cis rs7584330 0.910 rs6713555 chr2:238398182 A/G cg16989719 chr2:238392110 NA 0.38 6.58 0.34 1.77e-10 Prostate cancer; LUSC cis rs1832871 0.672 rs12525675 chr6:158708749 A/T cg07165851 chr6:158734300 TULP4 0.51 7.91 0.4 3.75e-14 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11149768 chr20:4129361 SMOX 0.48 6.89 0.35 2.79e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg11494091 chr17:61959527 GH2 0.64 13.57 0.6 1.06e-33 Prudent dietary pattern; LUSC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg12288994 chr5:1860383 NA 0.31 6.89 0.35 2.72e-11 Cardiovascular disease risk factors; LUSC cis rs644799 0.544 rs1622515 chr11:95523433 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.6 9.07 0.44 1.03e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7173743 1.000 rs11632020 chr15:79143759 C/T cg00540400 chr15:79124168 NA -0.34 -5.83 -0.3 1.3e-8 Coronary artery disease; LUSC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -6.05 -0.31 3.9e-9 Major depressive disorder; LUSC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg23630131 chr7:65973040 NA 0.21 5.86 0.31 1.14e-8 Aortic root size; LUSC cis rs1577917 1.000 rs1577919 chr6:86757296 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.77 -0.35 5.91e-11 Response to antipsychotic treatment; LUSC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg15017067 chr4:17643749 FAM184B 0.34 5.71 0.3 2.44e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2228479 0.681 rs62052184 chr16:89967217 T/C cg04013166 chr16:89971882 TCF25 0.65 7.5 0.38 5.98e-13 Skin colour saturation; LUSC cis rs950027 0.620 rs1145089 chr15:45652054 G/C cg26924012 chr15:45694286 SPATA5L1 0.79 12.43 0.56 2.13e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg21782813 chr7:2030301 MAD1L1 0.54 9.26 0.45 2.61e-18 Bipolar disorder and schizophrenia; LUSC cis rs9517320 0.967 rs7997785 chr13:99127985 T/A cg07423050 chr13:99094983 FARP1 0.34 6.33 0.33 8.08e-10 Longevity; LUSC cis rs6901250 0.851 rs339322 chr6:117193356 T/C cg12892004 chr6:117198278 RFX6 -0.44 -8.19 -0.41 5.5e-15 C-reactive protein levels; LUSC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg15921436 chr17:44337874 NA -0.73 -11.27 -0.52 3.58e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7917772 0.604 rs7908249 chr10:104373300 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1832871 1.000 rs827856 chr6:158705887 G/A cg07165851 chr6:158734300 TULP4 0.37 6.44 0.33 4.26e-10 Height; LUSC cis rs78456975 1.000 rs10177095 chr2:1570976 C/A cg01028140 chr2:1542097 TPO -0.6 -8.14 -0.41 7.81e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg01475377 chr6:109611718 NA -0.41 -7.26 -0.37 2.7e-12 Reticulocyte fraction of red cells; LUSC cis rs4423214 0.879 rs1792264 chr11:71150247 C/T cg05163923 chr11:71159392 DHCR7 -0.68 -8.94 -0.44 2.65e-17 Vitamin D levels; LUSC cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg08997352 chr12:9597637 DDX12 -0.6 -9.5 -0.46 4.24e-19 Breast size; LUSC cis rs61823972 0.547 rs12048743 chr1:205114873 C/G cg21545522 chr1:205238299 TMCC2 0.31 5.72 0.3 2.41e-8 Immature fraction of reticulocytes;Mean corpuscular volume;Mean corpuscular hemoglobin;Mean corpuscular hemoglobin concentration;High light scatter reticulocyte count; LUSC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg11766577 chr21:47581405 C21orf56 -0.4 -5.74 -0.3 2.14e-8 Testicular germ cell tumor; LUSC cis rs11758351 0.866 rs2069019 chr6:26205604 C/T cg01420254 chr6:26195488 NA 0.68 7.52 0.38 5.21e-13 Gout;Renal underexcretion gout; LUSC cis rs1949733 1.000 rs1357481 chr4:8496221 A/T cg13073564 chr4:8508604 NA -0.45 -8.38 -0.42 1.48e-15 Response to antineoplastic agents; LUSC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg13390004 chr1:15929781 NA 0.42 6.98 0.36 1.61e-11 Systolic blood pressure; LUSC trans rs11098499 0.863 rs2306457 chr4:120472839 T/A cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg03146154 chr1:46216737 IPP 0.5 7.46 0.38 7.52e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg00577361 chr1:21112950 HP1BP3 0.62 6.06 0.31 3.64e-9 Body mass index; LUSC cis rs6076065 0.692 rs6083111 chr20:23374667 A/G cg11657817 chr20:23433608 CST11 0.42 7.99 0.4 2.19e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs4285028 0.948 rs12493408 chr3:121692119 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.73 -9.54 -0.46 3.15e-19 Multiple sclerosis; LUSC cis rs12545109 0.959 rs12547974 chr8:57314785 G/T cg09654669 chr8:57350985 NA -0.61 -8.16 -0.41 7.11e-15 Obesity-related traits; LUSC trans rs2197308 0.740 rs11182967 chr12:37935140 A/C cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg15445000 chr17:37608096 MED1 -0.4 -6.79 -0.35 5.16e-11 Glomerular filtration rate (creatinine); LUSC cis rs897984 0.542 rs73530203 chr16:31099859 G/A cg02466173 chr16:30829666 NA -0.48 -8.89 -0.44 3.76e-17 Dementia with Lewy bodies; LUSC cis rs72960926 0.744 rs16884690 chr6:75046076 A/C cg03266952 chr6:74778945 NA -0.64 -6.14 -0.32 2.41e-9 Metabolite levels (MHPG); LUSC trans rs2392780 0.667 rs424281 chr8:128339426 G/A cg10897648 chr18:56338258 MALT1 -0.44 -6.59 -0.34 1.67e-10 Breast cancer (early onset); LUSC cis rs174601 0.833 rs174541 chr11:61565908 T/C cg19610905 chr11:61596333 FADS2 -0.53 -7.91 -0.4 3.82e-14 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg10523679 chr1:76189770 ACADM 0.91 15.9 0.66 8.53e-43 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17286411 0.750 rs11075910 chr16:71936733 A/G cg03805757 chr16:71968109 PKD1L3 0.42 6.96 0.36 1.79e-11 Blood protein levels; LUSC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg15445000 chr17:37608096 MED1 0.4 6.77 0.35 5.76e-11 Glomerular filtration rate (creatinine); LUSC trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.68 -0.39 1.83e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs8067354 0.574 rs2526354 chr17:57976658 A/G cg02344993 chr17:57696989 CLTC 0.48 6.74 0.35 6.76e-11 Hemoglobin concentration; LUSC cis rs72781680 0.898 rs72780188 chr2:24006065 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs7568458 0.704 rs10176176 chr2:85762048 A/T cg02493740 chr2:85810744 VAMP5 -0.35 -6.18 -0.32 1.87e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg25019033 chr10:957182 NA -0.53 -5.83 -0.3 1.28e-8 Eosinophil percentage of granulocytes; LUSC trans rs10511400 0.541 rs10049256 chr3:119920683 G/T cg02809009 chr19:50354510 PTOV1 -0.73 -6.52 -0.34 2.64e-10 Economic and political preferences (feminism/equality); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg24023618 chr6:114292459 HDAC2 0.46 6.95 0.36 1.95e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg08847335 chr10:891726 LARP4B 0.46 5.89 0.31 9.19e-9 Eosinophil percentage of granulocytes; LUSC trans rs2235573 0.527 rs139879 chr22:38364552 T/C cg19894588 chr14:64061835 NA 0.54 7.68 0.39 1.75e-13 Glioblastoma;Glioma; LUSC cis rs3796619 0.503 rs13147452 chr4:1078124 G/A cg27284194 chr4:1044797 NA 0.72 14.63 0.62 8.52e-38 Recombination rate (males); LUSC cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg06784218 chr1:46089804 CCDC17 -0.57 -11.33 -0.53 2.14e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2204008 0.617 rs11831608 chr12:38210687 C/T cg13010199 chr12:38710504 ALG10B -0.52 -7.73 -0.39 1.31e-13 Bladder cancer; LUSC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 2.93e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg05623727 chr3:50126028 RBM5 -0.36 -6.62 -0.34 1.4e-10 Body mass index; LUSC cis rs752010 0.841 rs58737163 chr1:42079821 G/T cg06885757 chr1:42089581 HIVEP3 0.41 8.37 0.42 1.55e-15 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg12560992 chr17:57184187 TRIM37 -0.84 -15.41 -0.64 7.53e-41 Intelligence (multi-trait analysis); LUSC cis rs8078723 0.677 rs8073254 chr17:38149350 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.4 0.38 1.1e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg00898013 chr13:113819073 PROZ -0.53 -7.91 -0.4 3.82e-14 Platelet distribution width; LUSC cis rs4253772 0.530 rs28362161 chr22:46807439 C/T cg24881330 chr22:46731750 TRMU 0.76 5.68 0.3 2.97e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs11676855 0.927 rs4341884 chr2:235918504 G/T cg14917874 chr2:235941519 SH3BP4 0.46 7.64 0.39 2.38e-13 Dialysis-related mortality; LUSC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg07716408 chr11:68623521 NA -0.31 -5.76 -0.3 1.88e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg23172400 chr8:95962367 TP53INP1 -0.47 -9.59 -0.46 2.13e-19 Type 2 diabetes; LUSC cis rs4595586 0.545 rs4623945 chr12:39364572 A/T cg26384229 chr12:38710491 ALG10B 0.5 7.2 0.37 3.91e-12 Morning vs. evening chronotype; LUSC cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg06547715 chr2:218990976 CXCR2 0.33 6.5 0.34 2.92e-10 Ulcerative colitis; LUSC cis rs3125734 0.719 rs10821972 chr10:64043735 G/A cg09941381 chr10:64027924 RTKN2 -0.35 -6.26 -0.32 1.19e-9 Rheumatoid arthritis; LUSC cis rs12421382 0.614 rs11213102 chr11:109385853 G/A cg16359550 chr11:109292809 C11orf87 0.33 5.95 0.31 6.88e-9 Schizophrenia; LUSC cis rs992157 1.000 rs6736362 chr2:219115108 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.54 8.31 0.41 2.37e-15 Colorectal cancer; LUSC cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg26384229 chr12:38710491 ALG10B 0.89 15.24 0.64 3.51e-40 Bladder cancer; LUSC cis rs9467773 0.836 rs1624440 chr6:26433329 G/A cg05738196 chr6:26577821 NA -0.65 -10.52 -0.5 1.56e-22 Intelligence (multi-trait analysis); LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg26516362 chr5:178986906 RUFY1 -0.54 -9.88 -0.48 2.22e-20 Lung cancer; LUSC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg14668632 chr7:2872130 GNA12 -0.45 -6.34 -0.33 7.54e-10 Height; LUSC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.17 0.41 6.46e-15 Homoarginine levels; LUSC cis rs9457247 0.555 rs2247325 chr6:167369992 A/G cg25258033 chr6:167368657 RNASET2 -0.4 -6.44 -0.33 4.28e-10 Crohn's disease; LUSC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg25258033 chr6:167368657 RNASET2 0.39 6.26 0.32 1.16e-9 Crohn's disease; LUSC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.641 rs55790290 chr16:68180242 A/G cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10464366 0.510 rs62442212 chr7:39146896 A/C cg15212455 chr7:39170539 POU6F2 0.55 9.21 0.45 3.73e-18 IgG glycosylation; LUSC cis rs17030434 0.954 rs6847810 chr4:154752789 C/T cg14289246 chr4:154710475 SFRP2 -0.54 -7.21 -0.37 3.7e-12 Electrocardiographic conduction measures; LUSC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs9467773 1.000 rs28558133 chr6:26531433 G/C cg05738196 chr6:26577821 NA 0.82 15.81 0.65 1.93e-42 Intelligence (multi-trait analysis); LUSC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg04871131 chr7:94954202 PON1 -0.38 -6.09 -0.32 3.12e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11674844 chr1:27216367 GPN2 0.53 7.27 0.37 2.53e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13217239 0.646 rs4269366 chr6:27016413 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.56 0.34 2.02e-10 Schizophrenia; LUSC cis rs10489202 0.683 rs202260 chr1:167956167 G/T cg24449463 chr1:168025552 DCAF6 -0.76 -12.62 -0.57 4.13e-30 Schizophrenia; LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg24060327 chr5:131705240 SLC22A5 0.69 11.35 0.53 1.86e-25 Blood metabolite levels; LUSC cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.55 -0.42 4.55e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6546550 0.901 rs3732266 chr2:70057448 T/G cg02498382 chr2:70120550 SNRNP27 -0.27 -6.31 -0.33 8.86e-10 Prevalent atrial fibrillation; LUSC cis rs10493773 0.609 rs11161656 chr1:86182414 A/G cg17807903 chr1:86174739 ZNHIT6 -0.55 -15.01 -0.63 2.84e-39 Urate levels in overweight individuals; LUSC cis rs7769051 0.711 rs7770081 chr6:133089569 G/T cg22852734 chr6:133119734 C6orf192 1.09 13.26 0.59 1.53e-32 Type 2 diabetes nephropathy; LUSC cis rs9788682 0.747 rs6495308 chr15:78907656 A/G cg24631222 chr15:78858424 CHRNA5 0.61 8.62 0.43 2.74e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs12410462 0.502 rs78101727 chr1:227732069 C/T cg04117972 chr1:227635322 NA 0.64 5.91 0.31 8.23e-9 Major depressive disorder; LUSC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.87 -0.31 1.03e-8 Alzheimer's disease (late onset); LUSC cis rs11051970 0.879 rs2243815 chr12:32576158 C/T cg02745156 chr12:32552066 NA 0.43 7.33 0.37 1.73e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6545883 0.839 rs778764 chr2:61785680 C/T cg15711740 chr2:61764176 XPO1 -0.42 -6.49 -0.33 3.03e-10 Tuberculosis; LUSC cis rs9341808 0.718 rs9448908 chr6:80898069 C/T cg08355045 chr6:80787529 NA 0.59 10.3 0.49 8.61e-22 Sitting height ratio; LUSC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg14773178 chr5:1868261 NA 0.32 5.88 0.31 1.01e-8 Cardiovascular disease risk factors; LUSC trans rs6762477 0.748 rs11717349 chr3:50223977 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.09 -0.36 7.79e-12 Menarche (age at onset); LUSC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg11764359 chr7:65958608 NA 0.54 7.12 0.36 6.5e-12 Aortic root size; LUSC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg03709012 chr19:19516395 GATAD2A 0.74 11.3 0.53 2.7e-25 Tonsillectomy; LUSC cis rs13394619 1.000 rs2884374 chr2:11731846 C/T cg07314298 chr2:11723111 GREB1 0.56 10.14 0.49 3.02e-21 Endometriosis; LUSC cis rs834811 0.831 rs834810 chr7:135879825 T/C cg01726295 chr7:135938950 NA 0.39 6.76 0.35 6.2e-11 Post-traumatic stress disorder; LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17167076 chr2:192109990 MYO1B -0.36 -5.98 -0.31 5.72e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg05896524 chr21:47604654 C21orf56 0.42 6.23 0.32 1.4e-9 Testicular germ cell tumor; LUSC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg06544989 chr22:39130855 UNC84B 0.35 6.03 0.31 4.35e-9 Menopause (age at onset); LUSC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.6 -7.45 -0.38 8.07e-13 Lung function (FEV1/FVC); LUSC trans rs208520 0.507 rs7755710 chr6:66783355 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.23 -25.83 -0.82 1.29e-81 Exhaled nitric oxide output; LUSC trans rs61931739 0.534 rs10844767 chr12:34152368 C/G cg13010199 chr12:38710504 ALG10B 0.54 8.46 0.42 8.75e-16 Morning vs. evening chronotype; LUSC cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg01483505 chr11:975446 AP2A2 0.4 5.67 0.3 3.03e-8 Alzheimer's disease (late onset); LUSC cis rs17401966 0.540 rs7546368 chr1:10418826 G/A cg17425144 chr1:10567563 PEX14 -0.34 -6.07 -0.32 3.45e-9 Hepatocellular carcinoma; LUSC cis rs17021463 0.902 rs34465979 chr4:95257554 C/A cg11021082 chr4:95130006 SMARCAD1 0.4 7.43 0.38 8.99e-13 Testicular germ cell tumor; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg13453750 chr1:205783389 SLC41A1 -0.32 -6.33 -0.33 7.74e-10 Menarche (age at onset); LUSC cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg22906224 chr7:99728672 NA 0.46 6.4 0.33 5.29e-10 Coronary artery disease; LUSC cis rs62400317 0.821 rs34455867 chr6:45172071 T/C cg18551225 chr6:44695536 NA -0.44 -7.21 -0.37 3.79e-12 Total body bone mineral density; LUSC cis rs4363385 0.553 rs11580383 chr1:152942192 A/G cg00922841 chr1:152955080 SPRR1A -0.36 -6.06 -0.31 3.63e-9 Inflammatory skin disease; LUSC cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg06552810 chr11:31128660 NA -0.42 -7.39 -0.37 1.19e-12 Red blood cell count; LUSC cis rs78572108 0.858 rs13384438 chr2:42265408 G/A cg00607755 chr2:42274082 PKDCC 0.36 6.52 0.34 2.61e-10 Total body bone mineral density; LUSC cis rs7568458 0.709 rs2028898 chr2:85777270 G/A cg17127132 chr2:85788382 GGCX 0.44 6.28 0.33 1.03e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4820539 1.000 rs756631 chr22:23463183 A/G cg14186256 chr22:23484241 RTDR1 0.95 17.83 0.7 2.02e-50 Bone mineral density; LUSC cis rs7589342 0.536 rs7563690 chr2:106396935 C/T cg14210321 chr2:106509881 NCK2 -0.4 -5.74 -0.3 2.09e-8 Addiction; LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg04546413 chr19:29218101 NA 0.71 11.39 0.53 1.26e-25 Methadone dose in opioid dependence; LUSC trans rs10435719 0.867 rs6999030 chr8:11795308 G/A cg15556689 chr8:8085844 FLJ10661 0.56 8.43 0.42 1.05e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg09839279 chr12:125627357 AACS -0.31 -5.72 -0.3 2.31e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs35883536 0.528 rs1414414 chr1:101028907 T/C cg06223162 chr1:101003688 GPR88 0.48 9.09 0.45 8.67e-18 Monocyte count; LUSC cis rs9814567 1.000 rs10935120 chr3:134233092 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 13.28 0.59 1.37e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg00579200 chr11:133705235 NA -0.39 -5.7 -0.3 2.58e-8 Childhood ear infection; LUSC cis rs3806843 1.000 rs4151682 chr5:140201264 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.77 -0.3 1.79e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg25811766 chr13:21894605 NA 0.62 9.61 0.47 1.83e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg15448220 chr1:150897856 SETDB1 0.4 5.72 0.3 2.34e-8 Melanoma; LUSC cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg00049323 chr5:472564 LOC25845 -0.48 -7.73 -0.39 1.28e-13 Cystic fibrosis severity; LUSC cis rs57590327 0.503 rs4856350 chr3:81503374 G/A cg07356753 chr3:81810745 GBE1 0.45 6.02 0.31 4.58e-9 Extraversion; LUSC cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg00677455 chr12:58241039 CTDSP2 0.49 7.28 0.37 2.48e-12 Intelligence (multi-trait analysis); LUSC cis rs8032315 0.965 rs35346340 chr15:91427872 G/C cg05469396 chr15:91419421 FURIN -0.43 -6.83 -0.35 4.1e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg11060661 chr22:24314208 DDT;DDTL 0.43 7.19 0.37 4.36e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17685 0.753 rs4573217 chr7:75733946 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.83 -0.39 6.5e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6545883 0.929 rs13413337 chr2:61747123 A/G cg15711740 chr2:61764176 XPO1 -0.48 -7.56 -0.38 3.91e-13 Tuberculosis; LUSC cis rs12545109 0.700 rs2670045 chr8:57393695 A/G cg09654669 chr8:57350985 NA -0.5 -6.69 -0.34 9.33e-11 Obesity-related traits; LUSC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg22166914 chr1:53195759 ZYG11B 0.67 11.31 0.53 2.54e-25 Monocyte count; LUSC trans rs5756813 0.811 rs4396807 chr22:38138379 G/C cg19894588 chr14:64061835 NA -0.48 -6.48 -0.33 3.21e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg18876405 chr7:65276391 NA -0.56 -8.82 -0.43 6.67e-17 Aortic root size; LUSC trans rs7618501 0.633 rs6771546 chr3:49968572 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.26 0.45 2.61e-18 Intelligence (multi-trait analysis); LUSC cis rs6982240 0.569 rs6992278 chr8:142279383 C/G cg27411547 chr8:142287226 NA -0.48 -8.41 -0.42 1.18e-15 Tonsillectomy; LUSC cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg24812749 chr6:127587940 RNF146 0.92 13.73 0.6 2.61e-34 Breast cancer; LUSC cis rs12579753 0.957 rs35001833 chr12:82188510 C/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.16 -0.32 2.07e-9 Resting heart rate; LUSC cis rs11098499 0.575 rs907204 chr4:120238654 G/A cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.23e-28 Corneal astigmatism; LUSC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg10909506 chr17:38081995 ORMDL3 0.33 5.87 0.31 1.02e-8 Self-reported allergy; LUSC cis rs3087591 0.573 rs731758 chr17:29723000 C/G cg24425628 chr17:29625626 OMG;NF1 0.45 6.67 0.34 1.09e-10 Hip circumference; LUSC cis rs2404602 0.647 rs10851892 chr15:77176491 T/C cg23625390 chr15:77176239 SCAPER -0.66 -9.95 -0.48 1.32e-20 Blood metabolite levels; LUSC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.63 -13.73 -0.6 2.43e-34 Hemoglobin concentration; LUSC trans rs11039798 0.588 rs6485869 chr11:48576903 G/T cg03929089 chr4:120376271 NA 0.58 6.49 0.33 3.04e-10 Axial length; LUSC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg03526776 chr6:41159608 TREML2 0.31 5.84 0.3 1.25e-8 Alzheimer's disease (late onset); LUSC trans rs12145833 0.538 rs10754798 chr1:243309958 A/G cg25284624 chr1:224180302 NA -0.66 -6.59 -0.34 1.76e-10 Obesity (early onset extreme); LUSC cis rs2439831 0.850 rs10438303 chr15:44016417 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.89 8.72 0.43 1.37e-16 Lung cancer in ever smokers; LUSC cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg26647111 chr11:31128758 NA -0.43 -6.12 -0.32 2.58e-9 Red blood cell count; LUSC cis rs754466 0.651 rs10824584 chr10:79625947 G/A cg17075019 chr10:79541650 NA -0.76 -12.26 -0.56 8.47e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9303280 0.754 rs3816470 chr17:37985801 A/G cg20243544 chr17:37824526 PNMT 0.4 5.85 0.3 1.17e-8 Self-reported allergy; LUSC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.57 0.5 9.83e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.22e-10 Aortic root size; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg24739457 chr1:205821442 NA 0.36 6.2 0.32 1.63e-9 Menarche (age at onset); LUSC cis rs4588572 0.643 rs1864172 chr5:77690945 T/C cg11547950 chr5:77652471 NA 0.53 7.46 0.38 7.57e-13 Triglycerides; LUSC trans rs1973993 0.967 rs6679458 chr1:96946253 G/T cg10631902 chr5:14652156 NA 0.5 8.43 0.42 1.03e-15 Weight; LUSC cis rs6750047 0.587 rs2163454 chr2:38279170 A/C cg07380506 chr2:38303506 CYP1B1 0.47 6.48 0.33 3.23e-10 Cutaneous malignant melanoma;Melanoma; LUSC cis rs34891900 0.507 rs738133 chr22:18205557 C/T cg19898043 chr22:18121309 BCL2L13 0.38 5.85 0.3 1.19e-8 Sum neutrophil eosinophil counts; LUSC cis rs12410462 0.681 rs4486420 chr1:227572321 T/A cg10327440 chr1:227177885 CDC42BPA -0.62 -5.79 -0.3 1.59e-8 Major depressive disorder; LUSC cis rs10203711 1.000 rs907108 chr2:239566285 T/C cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4595586 0.545 rs11615718 chr12:39395335 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs1881396 0.945 rs62141291 chr2:27784034 C/T cg27432699 chr2:27873401 GPN1 0.67 8.88 0.44 4.15e-17 Nonalcoholic fatty liver disease; LUSC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg11871910 chr12:69753446 YEATS4 0.68 10.44 0.5 2.93e-22 Blood protein levels; LUSC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg18305652 chr10:134549665 INPP5A 0.46 6.83 0.35 4.01e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs2736340 0.539 rs9644687 chr8:11323025 A/G cg15556689 chr8:8085844 FLJ10661 -0.52 -7.48 -0.38 6.61e-13 Systemic lupus erythematosus and Systemic sclerosis;Rheumatoid arthritis;Systemic lupus erythematosus;Kawasaki disease;Systemic lupus erythematosus or rheumatoid arthritis; LUSC cis rs9790314 1.000 rs1478565 chr3:161027464 C/T cg03342759 chr3:160939853 NMD3 -0.5 -8.39 -0.42 1.43e-15 Morning vs. evening chronotype; LUSC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg03264133 chr6:25882463 NA 0.38 6.29 0.33 9.97e-10 Intelligence (multi-trait analysis); LUSC cis rs11971779 0.648 rs6467852 chr7:139112591 A/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC trans rs3942852 0.606 rs10734561 chr11:48097480 C/T cg15704280 chr7:45808275 SEPT13 -0.59 -7.3 -0.37 2.1e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg27170947 chr2:26402098 FAM59B 0.65 9.35 0.46 1.28e-18 Gut microbiome composition (summer); LUSC cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg24692254 chr21:30365293 RNF160 0.92 19.44 0.73 7.64e-57 Dental caries; LUSC cis rs11625487 0.515 rs12434419 chr14:77855617 G/A cg20045696 chr14:77926864 AHSA1 -0.56 -8.85 -0.44 5.13e-17 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs7264396 0.790 rs12480622 chr20:34234620 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.21 -0.45 3.67e-18 Total cholesterol levels; LUSC cis rs6964587 0.869 rs11769726 chr7:91485231 A/G cg22709100 chr7:91322751 NA -0.4 -5.94 -0.31 6.99e-9 Breast cancer; LUSC cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs8114671 0.935 rs6060282 chr20:33767066 C/T cg07148914 chr20:33460835 GGT7 0.47 6.93 0.35 2.24e-11 Height; LUSC cis rs546131 0.928 rs516228 chr11:34838823 C/T cg06937548 chr11:34938143 PDHX;APIP 0.5 7.08 0.36 8.82e-12 Lung disease severity in cystic fibrosis; LUSC cis rs35306767 0.623 rs36062650 chr10:1142571 T/C cg26597838 chr10:835615 NA 0.48 6.19 0.32 1.79e-9 Eosinophil percentage of granulocytes; LUSC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.91 0.35 2.53e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11756438 0.547 rs2798327 chr6:119005353 C/T cg21191810 chr6:118973309 C6orf204 0.34 5.76 0.3 1.94e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7582720 1.000 rs6722332 chr2:203745327 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg03806693 chr22:41940476 POLR3H 0.98 13.49 0.59 2.08e-33 Vitiligo; LUSC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg00338735 chr4:53728038 RASL11B 0.49 5.67 0.3 3.11e-8 Optic nerve measurement (cup area); LUSC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg13607699 chr17:42295918 UBTF 0.48 7.51 0.38 5.58e-13 Total body bone mineral density; LUSC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg08392591 chr16:89556376 ANKRD11 0.39 5.82 0.3 1.4e-8 Multiple myeloma (IgH translocation); LUSC trans rs57046232 0.552 rs6038443 chr20:6328844 A/G cg21095983 chr6:86352623 SYNCRIP 0.5 7.35 0.37 1.49e-12 Colorectal cancer; LUSC cis rs11971779 0.618 rs6943788 chr7:139087697 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1371867 0.846 rs1660332 chr8:101309490 A/G cg00191853 chr8:101177733 SPAG1 0.39 6.51 0.34 2.69e-10 Atrioventricular conduction; LUSC cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg26384229 chr12:38710491 ALG10B -0.83 -15.22 -0.64 4.25e-40 Heart rate; LUSC cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg04455712 chr21:45112962 RRP1B 0.49 9.19 0.45 4.25e-18 Mean corpuscular volume; LUSC cis rs6445797 0.632 rs2029464 chr3:56661320 T/G cg13792233 chr3:56591045 CCDC66 0.41 5.72 0.3 2.33e-8 Gastritis; LUSC cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg08999081 chr20:33150536 PIGU 0.46 8.24 0.41 3.95e-15 Coronary artery disease; LUSC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg13206674 chr6:150067644 NUP43 0.61 9.77 0.47 5.34e-20 Lung cancer; LUSC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg14668632 chr7:2872130 GNA12 -0.44 -6.45 -0.33 3.86e-10 Height; LUSC cis rs950776 0.518 rs952215 chr15:78819153 C/T cg06917634 chr15:78832804 PSMA4 -0.82 -14.77 -0.63 2.34e-38 Sudden cardiac arrest; LUSC cis rs12594515 1.000 rs6493168 chr15:45986811 A/C cg06207120 chr15:45996521 NA 0.4 6.15 0.32 2.17e-9 Waist circumference;Weight; LUSC trans rs3733585 0.699 rs6823361 chr4:9963127 A/G cg26043149 chr18:55253948 FECH -0.44 -6.8 -0.35 4.9e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.24e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6714788 0.565 rs12712063 chr2:100663281 C/T cg07810366 chr2:100720526 AFF3 -0.36 -5.82 -0.3 1.41e-8 Intelligence (multi-trait analysis); LUSC cis rs4776059 1.000 rs11858743 chr15:52936330 G/A cg22715398 chr15:52968154 KIAA1370 -0.65 -9.45 -0.46 6.08e-19 Schizophrenia; LUSC cis rs9326248 0.520 rs1446105 chr11:116798544 C/T cg16524733 chr11:117070046 TAGLN 0.3 5.65 0.3 3.49e-8 Blood protein levels; LUSC cis rs1395 1.000 rs1275501 chr2:27419282 A/C cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.41 -6.7 -0.34 8.62e-11 Blood metabolite levels; LUSC cis rs9467773 0.595 rs13207371 chr6:26591074 G/A cg09904177 chr6:26538194 HMGN4 0.68 12.11 0.55 3.11e-28 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.647 rs11072636 chr15:77185786 A/G cg23625390 chr15:77176239 SCAPER -0.65 -10.02 -0.48 7.62e-21 Blood metabolite levels; LUSC cis rs8060686 0.641 rs76419201 chr16:68153553 G/A cg04539111 chr16:67997858 SLC12A4 -0.45 -6.03 -0.31 4.27e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg25767906 chr1:53392781 SCP2 -0.5 -9.16 -0.45 5.33e-18 Monocyte count; LUSC cis rs2652822 1.000 rs1126308 chr15:63429086 G/T cg02713581 chr15:63449717 RPS27L -0.42 -6.78 -0.35 5.5e-11 Metabolic traits; LUSC cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.69 0.6 3.62e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.5 -0.34 2.94e-10 Alzheimer's disease (late onset); LUSC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg09359103 chr1:154839909 KCNN3 -0.69 -15.34 -0.64 1.47e-40 Prostate cancer; LUSC cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.41 6.63 0.34 1.36e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6456156 0.586 rs12213801 chr6:167474084 T/A cg07741184 chr6:167504864 NA 0.4 7.01 0.36 1.3e-11 Primary biliary cholangitis; LUSC cis rs6012953 1.000 rs6063533 chr20:49159399 C/T cg13958625 chr20:49123093 NA -0.3 -6.6 -0.34 1.61e-10 Vitiligo; LUSC cis rs17155006 1.000 rs17155006 chr7:107757843 A/G cg05962710 chr7:107745446 LAMB4 -0.32 -5.81 -0.3 1.44e-8 Pneumococcal bacteremia; LUSC cis rs713477 0.654 rs11158040 chr14:55914607 T/C cg13175173 chr14:55914753 NA -0.29 -6.0 -0.31 5e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs1864400 0.696 rs2742239 chr10:43621712 A/G cg15436174 chr10:43711423 RASGEF1A -0.44 -7.34 -0.37 1.67e-12 Hirschsprung disease; LUSC cis rs714027 0.565 rs2285667 chr22:30384104 T/A cg11564601 chr22:30592435 NA 0.34 5.82 0.3 1.38e-8 Lymphocyte counts; LUSC cis rs13064411 0.627 rs28710051 chr3:113143531 G/A cg18753928 chr3:113234510 CCDC52 -0.49 -7.34 -0.37 1.62e-12 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg19046167 chr17:80928561 B3GNTL1 -0.47 -6.75 -0.35 6.48e-11 Glycated hemoglobin levels; LUSC cis rs727505 0.866 rs3214004 chr7:124720929 T/C cg23710748 chr7:124431027 NA -0.4 -6.96 -0.36 1.79e-11 Lewy body disease; LUSC cis rs1003719 0.715 rs8126941 chr21:38551542 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -10.0 -0.48 9.04e-21 Eye color traits; LUSC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg24250549 chr1:154909240 PMVK 0.64 10.36 0.49 5.4e-22 Prostate cancer; LUSC cis rs9287719 0.967 rs6761678 chr2:10746341 T/C cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs734999 0.549 rs6670198 chr1:2520527 T/C cg18854424 chr1:2615690 NA 0.51 10.34 0.49 6.28e-22 Ulcerative colitis; LUSC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg11812906 chr14:75593930 NEK9 0.64 10.97 0.51 4.2e-24 Height; LUSC cis rs870825 0.550 rs35981185 chr4:185639720 A/C cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.53 0.38 4.75e-13 Menarche (age at onset); LUSC cis rs34311866 0.808 rs11248060 chr4:964359 C/T cg14530993 chr4:882597 GAK 0.64 6.55 0.34 2.22e-10 Parkinson's disease; LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs6732160 0.691 rs4536673 chr2:73413462 A/T cg24220031 chr2:73402428 NA -0.23 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs1865760 0.713 rs9461229 chr6:25992279 G/T cg16482183 chr6:26056742 HIST1H1C 0.47 6.88 0.35 2.95e-11 Height; LUSC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg17376030 chr22:41985996 PMM1 0.48 6.03 0.31 4.25e-9 Vitiligo; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg08132940 chr7:1081526 C7orf50 -0.5 -6.15 -0.32 2.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg20818283 chr2:191399100 TMEM194B 0.43 6.76 0.35 6.15e-11 Pulse pressure; LUSC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg09034736 chr1:150693464 HORMAD1 0.42 5.82 0.3 1.42e-8 Melanoma; LUSC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg24110177 chr3:50126178 RBM5 0.55 8.94 0.44 2.71e-17 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.737 rs1497129 chr2:238369184 C/T cg16989719 chr2:238392110 NA -0.36 -6.31 -0.33 9.12e-10 Prostate cancer; LUSC cis rs6725041 0.547 rs1394784 chr2:213209325 G/A cg16329650 chr2:213403929 ERBB4 -0.42 -6.66 -0.34 1.15e-10 QT interval (ambient particulate matter interaction); LUSC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg16928487 chr17:17741425 SREBF1 -0.36 -6.67 -0.34 1.05e-10 Total body bone mineral density; LUSC cis rs1801251 0.964 rs10933411 chr2:233706847 A/G cg08000102 chr2:233561755 GIGYF2 -0.7 -11.58 -0.54 2.72e-26 Coronary artery disease; LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg00814883 chr7:100076585 TSC22D4 -0.67 -8.79 -0.43 8.24e-17 Platelet count; LUSC cis rs394563 0.591 rs237019 chr6:149727064 G/A cg11245181 chr6:149772854 ZC3H12D -0.31 -6.73 -0.35 7.49e-11 Dupuytren's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11277148 chr8:26371569 PNMA2 -0.56 -6.94 -0.36 2.1e-11 Bipolar disorder and schizophrenia; LUSC trans rs1325195 0.507 rs10798652 chr1:179061427 A/G cg11624085 chr17:8464688 MYH10 0.47 7.9 0.4 3.97e-14 IgE grass sensitization; LUSC cis rs1443512 0.812 rs1867299 chr12:54329975 T/C cg25024717 chr12:54324583 NA -0.4 -6.9 -0.35 2.69e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs2797160 0.935 rs1739379 chr6:126012593 T/C cg05039488 chr6:79577232 IRAK1BP1 0.44 6.58 0.34 1.85e-10 Endometrial cancer; LUSC cis rs7917772 0.628 rs4604806 chr10:104373904 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.08 0.52 1.68e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.46 -8.91 -0.44 3.38e-17 Monocyte percentage of white cells; LUSC trans rs156299 0.549 rs198316 chr7:24190531 A/T cg06529468 chr19:10676722 KRI1 0.38 6.11 0.32 2.83e-9 Vitamin D levels; LUSC cis rs11650494 0.908 rs8076023 chr17:47399633 C/G cg08112188 chr17:47440006 ZNF652 1.2 10.63 0.5 6.08e-23 Prostate cancer; LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg04025307 chr7:1156635 C7orf50 0.42 6.76 0.35 6.14e-11 Longevity;Endometriosis; LUSC trans rs634534 0.562 rs661335 chr11:65754061 G/A cg17712092 chr4:129076599 LARP1B 0.73 11.15 0.52 9.17e-25 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.93 -0.51 5.64e-24 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.95e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.49 6.22 0.32 1.46e-9 Multiple sclerosis; LUSC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg18477163 chr1:228402036 OBSCN 0.63 12.24 0.56 1.05e-28 Diastolic blood pressure; LUSC cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs2625529 0.617 rs2306576 chr15:72170686 C/T cg16672083 chr15:72433130 SENP8 0.47 7.9 0.4 4.12e-14 Red blood cell count; LUSC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg15839431 chr19:19639596 YJEFN3 -0.41 -5.72 -0.3 2.43e-8 Tonsillectomy; LUSC cis rs7215564 0.908 rs35151535 chr17:78661695 C/T cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs9467773 0.526 rs10946817 chr6:26364056 C/T cg09904177 chr6:26538194 HMGN4 -0.5 -7.91 -0.4 3.73e-14 Intelligence (multi-trait analysis); LUSC cis rs4280164 0.945 rs4981503 chr14:24786293 T/G cg16194253 chr14:24768981 DHRS1;C14orf21 0.6 7.1 0.36 7.38e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.64e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9650657 0.513 rs4841459 chr8:10782442 A/C cg27411982 chr8:10470053 RP1L1 -0.48 -7.37 -0.37 1.32e-12 Neuroticism; LUSC cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg03517284 chr6:25882590 NA -0.52 -9.67 -0.47 1.16e-19 Blood metabolite levels; LUSC cis rs35146811 0.807 rs6465761 chr7:99620277 G/C cg22906224 chr7:99728672 NA 0.54 7.95 0.4 2.82e-14 Coronary artery disease; LUSC cis rs6665290 0.669 rs12406714 chr1:227177061 T/C cg10327440 chr1:227177885 CDC42BPA -1.11 -28.89 -0.85 7.41e-93 Myeloid white cell count; LUSC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg13175981 chr1:150552382 MCL1 0.44 5.76 0.3 1.91e-8 Blood protein levels; LUSC cis rs6700896 0.500 rs2186246 chr1:66118009 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.36 0.33 6.62e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs877282 0.853 rs4579862 chr10:753298 A/C cg13042288 chr15:90349979 ANPEP -0.45 -6.29 -0.33 9.87e-10 Uric acid levels; LUSC cis rs2348418 0.798 rs4930826 chr12:28727318 A/T cg13890972 chr12:28721907 NA -0.35 -5.93 -0.31 7.44e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs4285028 0.948 rs13067270 chr3:121673901 A/C cg11130432 chr3:121712080 ILDR1 -0.63 -9.49 -0.46 4.55e-19 Multiple sclerosis; LUSC cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg05347473 chr6:146136440 FBXO30 0.53 8.91 0.44 3.27e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg09033563 chr22:24373618 LOC391322 -0.48 -6.78 -0.35 5.38e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg19812747 chr11:111475976 SIK2 -0.56 -8.11 -0.41 9.51e-15 Primary sclerosing cholangitis; LUSC cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.13 -0.41 8.71e-15 Chronic sinus infection; LUSC cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg00857998 chr1:205179979 DSTYK 0.55 8.48 0.42 7.29e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.59 0.34 1.7e-10 Lung cancer; LUSC cis rs8064299 0.597 rs2016126 chr17:72784932 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.93 19.36 0.73 1.53e-56 Monocyte count; LUSC cis rs7772486 0.875 rs56181683 chr6:146286620 A/G cg05347473 chr6:146136440 FBXO30 -0.52 -8.62 -0.43 2.74e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 0.782 rs8113006 chr19:19669441 C/G cg11244672 chr19:19639970 YJEFN3 0.44 5.91 0.31 8.52e-9 Bipolar disorder; LUSC cis rs8180040 0.726 rs6774733 chr3:46991241 G/A cg02527881 chr3:46936655 PTH1R -0.41 -7.41 -0.38 1.07e-12 Colorectal cancer; LUSC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg20821713 chr7:1055600 C7orf50 0.51 6.47 0.33 3.4e-10 Bronchopulmonary dysplasia; LUSC cis rs2295359 0.892 rs4655687 chr1:67649946 C/T cg17031739 chr1:67600172 NA 0.46 7.17 0.37 4.72e-12 Psoriasis; LUSC cis rs17604090 0.761 rs115923387 chr7:29720702 A/G cg19413766 chr7:29689036 LOC646762 -0.65 -8.13 -0.41 8.39e-15 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg14440974 chr22:39074834 NA -0.39 -6.44 -0.33 4.23e-10 Menopause (age at onset); LUSC cis rs354225 0.544 rs10182836 chr2:54808504 T/G cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs9733 0.650 rs3738485 chr1:150552392 C/G cg09365446 chr1:150670422 GOLPH3L -0.41 -5.94 -0.31 7.12e-9 Tonsillectomy; LUSC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11039798 0.925 rs6485831 chr11:48455031 A/T cg15704280 chr7:45808275 SEPT13 0.67 6.23 0.32 1.38e-9 Axial length; LUSC cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg08754478 chr10:133766260 PPP2R2D -0.63 -8.11 -0.41 9.61e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15541609 chr14:100705844 YY1 0.62 6.08 0.32 3.36e-9 Cognitive performance; LUSC cis rs637571 0.780 rs677029 chr11:65683531 A/G cg26695010 chr11:65641043 EFEMP2 -0.48 -7.05 -0.36 1.04e-11 Eosinophil percentage of white cells; LUSC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg26818010 chr10:134567672 INPP5A -0.79 -10.57 -0.5 1.05e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg03161606 chr19:29218774 NA 0.5 6.77 0.35 5.83e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7122539 0.646 rs627330 chr11:66602099 C/T cg18002602 chr11:66138449 SLC29A2 -0.33 -5.87 -0.31 1.08e-8 HIV-1 susceptibility; LUSC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg23490090 chr17:78081364 GAA -0.34 -5.78 -0.3 1.7e-8 Yeast infection; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08305803 chr16:28565427 CCDC101 0.73 6.05 0.31 3.87e-9 Cognitive performance; LUSC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.15e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs34779708 0.931 rs7920095 chr10:35303334 G/A cg04310649 chr10:35416472 CREM -0.43 -6.45 -0.33 3.94e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg27284194 chr4:1044797 NA 0.35 5.7 0.3 2.58e-8 Obesity-related traits; LUSC cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.29 -0.37 2.2e-12 Menopause (age at onset); LUSC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg26408565 chr15:76604113 ETFA -0.5 -8.05 -0.4 1.46e-14 Blood metabolite levels; LUSC cis rs2235544 0.588 rs664758 chr1:54461263 C/T cg25741118 chr1:54482237 LDLRAD1 0.33 7.61 0.38 2.84e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs1559088 0.948 rs12610266 chr19:33581237 C/G cg27124370 chr19:33622961 WDR88 -0.59 -7.72 -0.39 1.4e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg10729496 chr3:10149963 C3orf24 0.57 7.09 0.36 8.19e-12 Alzheimer's disease; LUSC cis rs4851254 0.618 rs7572939 chr2:100654914 A/G cg22139774 chr2:100720529 AFF3 -0.44 -5.75 -0.3 2.02e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg07636037 chr3:49044803 WDR6 1.05 18.99 0.72 4.92e-55 Parkinson's disease; LUSC cis rs9581857 0.547 rs9579087 chr13:28059780 G/A cg22138327 chr13:27999177 GTF3A 0.81 8.38 0.42 1.49e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 9.04 0.44 1.28e-17 Menopause (age at onset); LUSC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg02487422 chr3:49467188 NICN1 0.48 7.63 0.39 2.46e-13 Resting heart rate; LUSC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.77 -7.0 -0.36 1.42e-11 Cerebrospinal P-tau181p levels; LUSC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg12463550 chr7:65579703 CRCP -0.56 -8.35 -0.42 1.78e-15 Aortic root size; LUSC cis rs34779708 0.966 rs4934725 chr10:35398236 T/C cg03585969 chr10:35415529 CREM 0.62 8.97 0.44 2.2e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1965732 1.000 rs11696000 chr2:3709907 A/G cg10645314 chr2:3704589 ALLC -0.37 -6.47 -0.33 3.55e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2730245 0.527 rs2527197 chr7:158735260 G/A cg24397884 chr7:158709396 WDR60 -0.8 -9.06 -0.44 1.09e-17 Height; LUSC cis rs10088262 0.591 rs13270541 chr8:124794849 G/A cg20713898 chr8:124780851 FAM91A1 -0.54 -7.49 -0.38 6.06e-13 Pancreatic cancer; LUSC cis rs9467711 0.559 rs9348721 chr6:26485573 A/G cg12826209 chr6:26865740 GUSBL1 0.67 5.85 0.31 1.14e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs6460942 0.591 rs62448726 chr7:12330881 A/G cg06484146 chr7:12443880 VWDE -0.57 -5.98 -0.31 5.79e-9 Coronary artery disease; LUSC cis rs477692 1.000 rs503660 chr10:131418999 A/G cg11019008 chr10:131425282 MGMT 0.39 6.02 0.31 4.58e-9 Response to temozolomide; LUSC cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg15839431 chr19:19639596 YJEFN3 -0.59 -6.32 -0.33 8.52e-10 Bipolar disorder; LUSC cis rs7917772 0.604 rs7908249 chr10:104373300 A/G cg05855489 chr10:104503620 C10orf26 -0.48 -7.35 -0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9650657 0.655 rs1991651 chr8:10706411 C/G cg27411982 chr8:10470053 RP1L1 0.42 6.81 0.35 4.56e-11 Neuroticism; LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.96e-10 Menopause (age at onset); LUSC cis rs3008870 0.755 rs12562761 chr1:67396739 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.45 0.56 1.78e-29 Lymphocyte percentage of white cells; LUSC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg03354898 chr7:1950403 MAD1L1 -0.36 -6.99 -0.36 1.55e-11 Schizophrenia; LUSC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg11344533 chr11:111475393 SIK2 0.48 6.52 0.34 2.55e-10 Primary sclerosing cholangitis; LUSC trans rs7939886 0.623 rs77065109 chr11:55906843 G/A cg03929089 chr4:120376271 NA 0.76 6.1 0.32 2.93e-9 Myopia (pathological); LUSC cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg16006841 chr5:176797999 RGS14 0.63 9.91 0.48 1.87e-20 Hemoglobin concentration;Hematocrit; LUSC cis rs907683 0.559 rs4674394 chr2:220289870 C/T cg15015639 chr2:220282977 DES -0.31 -7.07 -0.36 9.11e-12 Resting heart rate; LUSC cis rs7412746 0.566 rs11204743 chr1:150890406 A/T cg09365446 chr1:150670422 GOLPH3L 0.44 6.1 0.32 2.94e-9 Melanoma; LUSC trans rs7980799 0.682 rs1447873 chr12:33615236 A/G cg26384229 chr12:38710491 ALG10B -0.58 -8.7 -0.43 1.5e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs4862307 0.514 rs7696176 chr4:185014390 A/G cg06737308 chr4:185021514 ENPP6 0.71 13.23 0.59 2.04e-32 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg05347473 chr6:146136440 FBXO30 0.46 7.96 0.4 2.72e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6714788 0.546 rs12712062 chr2:100654307 A/T cg07810366 chr2:100720526 AFF3 -0.39 -6.08 -0.32 3.25e-9 Intelligence (multi-trait analysis); LUSC cis rs6121246 0.779 rs6060763 chr20:30282223 A/G cg13852791 chr20:30311386 BCL2L1 0.85 11.51 0.53 4.93e-26 Mean corpuscular hemoglobin; LUSC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg23711669 chr6:146136114 FBXO30 -0.87 -16.17 -0.66 7.42e-44 Lobe attachment (rater-scored or self-reported); LUSC trans rs2832191 0.692 rs2254872 chr21:30414724 C/T cg14791747 chr16:20752902 THUMPD1 -0.41 -6.21 -0.32 1.54e-9 Dental caries; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01460805 chr8:22549804 EGR3 -0.41 -5.96 -0.31 6.29e-9 Electrocardiographic conduction measures; LUSC cis rs2303282 0.933 rs34793257 chr16:56494071 C/T cg00500540 chr16:56394104 NA -0.45 -7.23 -0.37 3.42e-12 Breast cancer; LUSC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.97 -0.4 2.61e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg19077165 chr18:44547161 KATNAL2 -0.37 -5.68 -0.3 2.94e-8 Personality dimensions; LUSC cis rs8044995 0.563 rs3785127 chr16:68399590 C/G cg09835421 chr16:68378352 PRMT7 -0.77 -8.61 -0.43 3.01e-16 Schizophrenia; LUSC cis rs12760731 0.720 rs7548163 chr1:178306695 G/A cg00404053 chr1:178313656 RASAL2 0.56 6.1 0.32 2.98e-9 Obesity-related traits; LUSC cis rs11098499 0.954 rs17046116 chr4:120387259 G/A cg24375607 chr4:120327624 NA 0.79 11.67 0.54 1.27e-26 Corneal astigmatism; LUSC cis rs9837602 1.000 rs1021103 chr3:99603230 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.39 -5.83 -0.3 1.28e-8 Breast cancer; LUSC cis rs9378688 1.000 rs3778568 chr6:2225680 C/T cg12303981 chr6:2244766 GMDS -0.52 -6.27 -0.32 1.15e-9 Caudate nucleus volume; LUSC cis rs757110 0.770 rs11024271 chr11:17395540 T/C cg15432903 chr11:17409602 KCNJ11 0.61 10.79 0.51 1.68e-23 Type 2 diabetes; LUSC cis rs356992 0.915 rs168562 chr2:60747192 T/C cg08426369 chr2:60753602 BCL11A 0.44 6.05 0.31 3.86e-9 Educational attainment (years of education); LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg24675658 chr1:53192096 ZYG11B -0.57 -8.84 -0.44 5.44e-17 Monocyte count; LUSC trans rs2490361 1.000 rs2490360 chr1:237326980 C/T cg15653282 chr18:11689218 GNAL 0.39 6.02 0.31 4.68e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg22467129 chr15:76604101 ETFA -0.52 -8.35 -0.42 1.9e-15 Blood metabolite levels; LUSC cis rs9287719 0.967 rs4668691 chr2:10740494 C/T cg03983476 chr2:10830698 NOL10 -0.37 -5.71 -0.3 2.56e-8 Prostate cancer; LUSC cis rs7805747 0.523 rs13239239 chr7:151423196 C/T cg17611936 chr7:151411526 PRKAG2 -0.43 -5.86 -0.31 1.14e-8 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); LUSC cis rs12422267 0.536 rs12423631 chr12:132606886 C/T cg09764611 chr12:132620959 NA -0.58 -8.04 -0.4 1.59e-14 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs965513 1.000 rs7028661 chr9:100538470 A/G cg13688889 chr9:100608707 NA -0.57 -8.61 -0.43 2.88e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.26 0.37 2.8e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs1728785 1.000 rs11075680 chr16:68565700 G/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg23711669 chr6:146136114 FBXO30 -0.83 -15.15 -0.64 8.08e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs11051970 0.679 rs2651366 chr12:32560431 T/C cg24626660 chr12:32551988 NA 0.31 5.7 0.3 2.7e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3125734 0.633 rs3852412 chr10:64050288 C/T cg09941381 chr10:64027924 RTKN2 -0.39 -7.06 -0.36 9.64e-12 Rheumatoid arthritis; LUSC cis rs9467773 1.000 rs1321481 chr6:26538210 A/T cg05738196 chr6:26577821 NA 0.81 15.89 0.66 9.79e-43 Intelligence (multi-trait analysis); LUSC cis rs763121 0.962 rs5757130 chr22:38937794 G/A cg06022373 chr22:39101656 GTPBP1 0.76 12.13 0.55 2.62e-28 Menopause (age at onset); LUSC trans rs11039798 0.588 rs7483361 chr11:48593786 G/A cg03929089 chr4:120376271 NA 0.59 6.58 0.34 1.79e-10 Axial length; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.77 0.39 1e-13 Lymphocyte counts; LUSC cis rs1577917 1.000 rs6454513 chr6:86720049 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.43 6.35 0.33 6.95e-10 Response to antipsychotic treatment; LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg12016809 chr21:47604291 C21orf56 0.46 6.91 0.35 2.52e-11 Testicular germ cell tumor; LUSC cis rs2072499 0.966 rs2244144 chr1:156184598 G/A cg25208724 chr1:156163844 SLC25A44 1.08 22.65 0.78 1.77e-69 Testicular germ cell tumor; LUSC cis rs2204008 0.645 rs9989043 chr12:38238505 G/A cg26384229 chr12:38710491 ALG10B -0.58 -8.58 -0.42 3.62e-16 Bladder cancer; LUSC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg12463550 chr7:65579703 CRCP -0.51 -7.42 -0.38 9.84e-13 Aortic root size; LUSC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.88 -0.4 4.57e-14 Height; LUSC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg17340268 chr14:105411764 AHNAK2 -0.4 -6.29 -0.33 9.71e-10 Rheumatoid arthritis; LUSC cis rs6542838 0.588 rs4851175 chr2:99530118 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.48 -0.38 6.52e-13 Fear of minor pain; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg00431813 chr7:1051703 C7orf50 -0.43 -7.37 -0.37 1.31e-12 Longevity;Endometriosis; LUSC cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -7.02 -0.36 1.28e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs738322 0.804 rs4821743 chr22:38514906 A/G cg25457927 chr22:38595422 NA -0.35 -6.73 -0.35 7.45e-11 Cutaneous nevi; LUSC cis rs4631830 0.900 rs7920517 chr10:51532621 G/A cg20129853 chr10:51489980 NA -0.35 -6.99 -0.36 1.49e-11 Prostate-specific antigen levels; LUSC cis rs9467773 0.967 rs9358954 chr6:26531178 A/G cg05738196 chr6:26577821 NA 0.82 15.81 0.65 1.93e-42 Intelligence (multi-trait analysis); LUSC cis rs13401104 0.796 rs10929169 chr2:237115532 C/T cg19324714 chr2:237145437 ASB18 0.43 5.65 0.3 3.35e-8 Educational attainment; LUSC cis rs9435341 0.826 rs1730858 chr1:107619244 T/C cg09367891 chr1:107599246 PRMT6 -0.5 -7.77 -0.39 1e-13 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg03806693 chr22:41940476 POLR3H -0.95 -12.89 -0.58 3.97e-31 Vitiligo; LUSC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg10556349 chr10:835070 NA 0.56 6.16 0.32 2.05e-9 Eosinophil percentage of granulocytes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03006338 chr19:4402502 CHAF1A -0.45 -5.95 -0.31 6.85e-9 Hepatitis; LUSC cis rs3020736 0.500 rs2839708 chr22:42500745 A/G cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.56e-24 Aortic root size; LUSC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg13647721 chr17:30228624 UTP6 -0.63 -6.11 -0.32 2.85e-9 Hip circumference adjusted for BMI; LUSC cis rs1355223 0.573 rs947501 chr11:34753375 A/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.16 -0.32 2.1e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7089973 0.872 rs7909566 chr10:116629136 A/G cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 5.96e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4909189 1.000 rs11764065 chr7:158135974 T/C cg24154853 chr7:158122151 PTPRN2 0.35 5.81 0.3 1.47e-8 Response to amphetamines; LUSC trans rs72674100 1.000 rs28504129 chr4:97990879 G/A cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.66 -7.04 -0.36 1.07e-11 Ankle injury; LUSC cis rs17253792 0.731 rs79483151 chr14:56048851 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs6570726 1.000 rs444564 chr6:145859795 G/C cg23711669 chr6:146136114 FBXO30 0.72 12.66 0.57 2.78e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs4974559 0.739 rs6599298 chr4:1298122 A/G cg02980000 chr4:1222292 CTBP1 1.02 9.33 0.45 1.5e-18 Systolic blood pressure; LUSC trans rs12145833 0.538 rs61833885 chr1:243397188 C/A cg01826367 chr1:224180288 NA 0.7 6.3 0.33 9.36e-10 Obesity (early onset extreme); LUSC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg16060761 chr17:80687452 NA 0.45 7.21 0.37 3.81e-12 Breast cancer; LUSC cis rs2692947 0.759 rs1917890 chr2:96672001 C/T cg22654517 chr2:96458247 NA 0.31 6.13 0.32 2.54e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs13392177 0.647 rs10932761 chr2:219064391 T/A cg00012203 chr2:219082015 ARPC2 -0.75 -12.8 -0.57 8.66e-31 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs644799 0.562 rs1254989 chr11:95508121 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.73 10.85 0.51 1.06e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9314614 0.934 rs2980955 chr8:6694434 A/G cg27319216 chr8:6693540 XKR5 -0.35 -6.35 -0.33 6.92e-10 IgA nephropathy;White blood cell count (basophil); LUSC cis rs9522267 0.535 rs914037 chr13:112235308 A/G cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 2.99e-8 Hepatitis; LUSC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg20891283 chr12:69753455 YEATS4 0.91 17.45 0.69 6.11e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs7772486 0.840 rs2814864 chr6:146345046 A/C cg23711669 chr6:146136114 FBXO30 0.71 11.49 0.53 5.85e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs68170813 0.559 rs78610616 chr7:106951369 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.86 -0.31 1.11e-8 Coronary artery disease; LUSC cis rs5758659 0.967 rs5758670 chr22:42636687 T/C cg04733989 chr22:42467013 NAGA 0.41 6.52 0.34 2.54e-10 Cognitive function; LUSC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg15147215 chr3:52552868 STAB1 -0.31 -6.16 -0.32 2.06e-9 Bipolar disorder; LUSC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg04240660 chr16:89714849 CHMP1A -0.41 -6.48 -0.33 3.28e-10 Hemoglobin concentration; LUSC cis rs3806843 1.000 rs1476768 chr5:140173597 G/A cg19875535 chr5:140030758 IK 0.5 8.28 0.41 3.06e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs17253792 0.822 rs10139905 chr14:56170031 T/C cg01858014 chr14:56050164 KTN1 -0.71 -6.35 -0.33 6.97e-10 Putamen volume; LUSC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg06484146 chr7:12443880 VWDE -0.69 -7.2 -0.37 4.01e-12 Coronary artery disease; LUSC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.91 -0.31 8.41e-9 Crohn's disease; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC trans rs2392780 0.596 rs283705 chr8:128317450 C/T cg10897648 chr18:56338258 MALT1 -0.42 -6.24 -0.32 1.31e-9 Breast cancer (early onset); LUSC trans rs7980799 0.654 rs10844618 chr12:33625010 A/G cg26384229 chr12:38710491 ALG10B -0.58 -8.7 -0.43 1.5e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg18230493 chr5:56204884 C5orf35 0.53 8.46 0.42 8.41e-16 Coronary artery disease; LUSC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg27286337 chr10:134555280 INPP5A 0.91 11.87 0.54 2.36e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs3806843 0.900 rs2563287 chr5:140124786 C/T cg25815440 chr2:42134162 NA -0.27 -6.33 -0.33 8.07e-10 Depressive symptoms (multi-trait analysis); LUSC cis rs17604090 0.877 rs28516764 chr7:29685245 T/G cg19413766 chr7:29689036 LOC646762 -0.58 -6.93 -0.35 2.12e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC trans rs12310956 0.510 rs4931743 chr12:33867588 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.9 0.35 2.69e-11 Morning vs. evening chronotype; LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg00814883 chr7:100076585 TSC22D4 -0.73 -9.8 -0.47 4.39e-20 Platelet count; LUSC cis rs11031096 0.711 rs17283923 chr11:4173841 C/T cg18678763 chr11:4115507 RRM1 -0.4 -5.68 -0.3 2.99e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg02551604 chr5:131831745 NA -0.4 -6.27 -0.32 1.1e-9 Asthma (sex interaction); LUSC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.84 0.39 6.23e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg22875332 chr1:76189707 ACADM -0.7 -9.59 -0.46 2.15e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17401966 0.540 rs11121557 chr1:10448260 T/G cg19773385 chr1:10388646 KIF1B -0.37 -6.56 -0.34 2.02e-10 Hepatocellular carcinoma; LUSC trans rs3960554 0.808 rs61303167 chr7:75671175 G/T cg19862616 chr7:65841803 NCRNA00174 0.84 9.53 0.46 3.45e-19 Eotaxin levels; LUSC cis rs1577917 0.958 rs1838955 chr6:86565449 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.99 -0.44 1.88e-17 Response to antipsychotic treatment; LUSC cis rs7681440 0.935 rs3756059 chr4:90757272 G/A cg15133208 chr4:90757351 SNCA -0.34 -5.99 -0.31 5.45e-9 Dementia with Lewy bodies; LUSC cis rs977987 0.806 rs766521 chr16:75424154 A/G cg03315344 chr16:75512273 CHST6 -0.47 -8.99 -0.44 1.88e-17 Dupuytren's disease; LUSC cis rs2439831 1.000 rs2439831 chr15:43784475 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.94 10.48 0.5 2.15e-22 Lung cancer in ever smokers; LUSC trans rs6869502 0.871 rs13354207 chr5:110151791 C/G cg10196696 chr5:157247843 CLINT1 -0.41 -5.96 -0.31 6.48e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg20476274 chr7:133979776 SLC35B4 0.79 13.93 0.61 4.16e-35 Mean platelet volume; LUSC cis rs1371867 0.846 rs2453624 chr8:101230523 A/G cg06002616 chr8:101225028 SPAG1 0.47 7.65 0.39 2.16e-13 Atrioventricular conduction; LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.27e-22 Body mass index; LUSC trans rs9944715 1.000 rs9952972 chr18:43842617 T/A cg01718231 chr17:29326311 RNF135 -0.5 -6.95 -0.36 1.97e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs6546550 0.935 rs3214007 chr2:70098808 A/G cg02498382 chr2:70120550 SNRNP27 -0.31 -7.62 -0.38 2.62e-13 Prevalent atrial fibrillation; LUSC cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg08873628 chr1:175162347 KIAA0040 -0.43 -6.31 -0.33 8.92e-10 Diastolic blood pressure; LUSC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg24881330 chr22:46731750 TRMU 0.88 8.87 0.44 4.44e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg14416269 chr4:6271139 WFS1 0.54 11.41 0.53 1.08e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.36 -0.37 1.47e-12 Menopause (age at onset); LUSC cis rs11971779 0.680 rs7785903 chr7:139122643 T/C cg07862535 chr7:139043722 LUC7L2 0.6 7.64 0.39 2.25e-13 Diisocyanate-induced asthma; LUSC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg04166393 chr7:2884313 GNA12 0.4 5.8 0.3 1.57e-8 Height; LUSC cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg18132916 chr6:79620363 NA -0.39 -5.9 -0.31 8.72e-9 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg17264618 chr3:40429014 ENTPD3 0.36 7.58 0.38 3.48e-13 Renal cell carcinoma; LUSC cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg05585544 chr11:47624801 NA -0.42 -7.15 -0.36 5.43e-12 Subjective well-being; LUSC cis rs1044826 0.642 rs295478 chr3:139223135 G/A cg00490450 chr3:139108681 COPB2 0.46 7.02 0.36 1.27e-11 Obesity-related traits; LUSC cis rs7903847 0.642 rs11189179 chr10:99143320 T/C cg08345082 chr10:99160200 RRP12 -0.36 -7.3 -0.37 2.19e-12 Granulocyte percentage of myeloid white cells; LUSC trans rs11098499 0.909 rs9759478 chr4:120367998 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.33 0.33 8.04e-10 Corneal astigmatism; LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.72 0.65 4.67e-42 Platelet count; LUSC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC cis rs2204008 0.529 rs1315350 chr12:38164282 C/A cg26384229 chr12:38710491 ALG10B -0.66 -10.17 -0.49 2.44e-21 Bladder cancer; LUSC trans rs979233 0.502 rs10074493 chr5:42111968 C/T cg07010552 chr17:7358735 CHRNB1 -0.4 -6.06 -0.31 3.74e-9 Systemic lupus erythematosus; LUSC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg09913183 chr17:42254507 C17orf65;ASB16 0.55 8.33 0.41 2.16e-15 Total body bone mineral density; LUSC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg12350822 chr6:88032061 C6orf162;GJB7 0.65 13.71 0.6 3.03e-34 Monocyte percentage of white cells; LUSC cis rs116988415 0.584 rs2269307 chr14:65245007 G/A cg00114569 chr14:65239327 SPTB 0.62 6.5 0.34 2.88e-10 Daytime sleep phenotypes; LUSC cis rs6599077 0.950 rs9863161 chr3:40105336 T/C cg13683864 chr3:40499215 RPL14 -0.61 -7.6 -0.38 3.09e-13 Sleep-related phenotypes; LUSC cis rs7267979 0.565 rs4815432 chr20:25556403 A/C cg03522245 chr20:25566470 NINL -0.38 -5.98 -0.31 5.66e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs765787 0.530 rs10851423 chr15:45515950 G/A cg24006582 chr15:45444508 DUOX1 0.65 9.45 0.46 6.25e-19 Uric acid levels; LUSC cis rs17270561 0.609 rs3922699 chr6:25734969 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg04518342 chr5:131593106 PDLIM4 0.35 6.39 0.33 5.47e-10 Blood metabolite levels; LUSC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg18827107 chr12:86230957 RASSF9 -0.46 -6.88 -0.35 3.04e-11 Major depressive disorder; LUSC trans rs11250097 0.535 rs11250086 chr8:10769783 A/G cg15556689 chr8:8085844 FLJ10661 -0.57 -8.09 -0.4 1.14e-14 Neuroticism; LUSC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg06671706 chr8:8559999 CLDN23 -0.53 -6.97 -0.36 1.69e-11 Obesity-related traits; LUSC cis rs4891159 0.756 rs3892540 chr18:74118058 C/T cg24786174 chr18:74118243 ZNF516 -0.85 -15.63 -0.65 1.02e-41 Longevity; LUSC cis rs6939532 0.522 rs13218591 chr6:26376832 T/C cg05738196 chr6:26577821 NA -0.44 -6.16 -0.32 2.05e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg02551604 chr5:131831745 NA -0.41 -6.23 -0.32 1.37e-9 Asthma (sex interaction); LUSC cis rs6163 0.588 rs3818708 chr10:104503584 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.49 -0.33 3.17e-10 Waist circumference;Hip circumference; LUSC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg06453172 chr10:134556979 INPP5A -0.5 -6.35 -0.33 6.9e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg04871131 chr7:94954202 PON1 -0.38 -6.12 -0.32 2.65e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg07741184 chr6:167504864 NA -0.35 -6.39 -0.33 5.46e-10 Crohn's disease; LUSC cis rs6580649 0.831 rs4760620 chr12:48559642 A/G cg24011408 chr12:48396354 COL2A1 0.48 6.56 0.34 2e-10 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26500801 chr19:10613855 KEAP1 -0.39 -6.0 -0.31 5.22e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9788682 0.668 rs2036529 chr15:78726272 A/T cg24631222 chr15:78858424 CHRNA5 -0.66 -8.72 -0.43 1.34e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg04871131 chr7:94954202 PON1 0.38 6.77 0.35 5.63e-11 Paraoxonase activity; LUSC cis rs8062405 0.789 rs1968752 chr16:28631585 G/T cg16576597 chr16:28551801 NUPR1 0.3 6.09 0.32 3.06e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4969178 0.965 rs2292642 chr17:76395430 C/T cg05887092 chr17:76393375 PGS1 0.54 9.77 0.47 5.57e-20 HDL cholesterol levels; LUSC cis rs977987 0.836 rs34673655 chr16:75323559 T/C cg03315344 chr16:75512273 CHST6 0.47 8.62 0.43 2.7e-16 Dupuytren's disease; LUSC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.0 -0.36 1.44e-11 Alzheimer's disease (late onset); LUSC cis rs9434723 0.841 rs9435152 chr1:9308249 C/T cg04199779 chr1:9294473 H6PD 0.56 6.23 0.32 1.38e-9 Height; LUSC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC cis rs34779708 0.966 rs113170867 chr10:35450147 C/T cg04310649 chr10:35416472 CREM -0.42 -6.47 -0.33 3.4e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg06671706 chr8:8559999 CLDN23 0.49 6.43 0.33 4.36e-10 Obesity-related traits; LUSC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg14552801 chr7:65878734 NA 0.38 5.93 0.31 7.68e-9 Aortic root size; LUSC cis rs62027291 0.898 rs78138579 chr15:77308255 C/T cg26408565 chr15:76604113 ETFA 0.51 6.15 0.32 2.27e-9 Plateletcrit; LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg18404041 chr3:52824283 ITIH1 -0.57 -11.03 -0.52 2.41e-24 Bipolar disorder; LUSC cis rs4268898 0.662 rs9784114 chr2:24437517 C/T cg06627628 chr2:24431161 ITSN2 -0.88 -13.13 -0.58 4.86e-32 Asthma; LUSC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg03806693 chr22:41940476 POLR3H 0.95 13.81 0.6 1.29e-34 Vitiligo; LUSC trans rs629535 0.748 rs58675625 chr8:70034924 T/C cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs7945705 0.791 rs10769958 chr11:8815115 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.32 -6.56 -0.34 2.05e-10 Hemoglobin concentration; LUSC cis rs12908161 1.000 rs62021219 chr15:85256159 C/T cg12863693 chr15:85201151 NMB 0.42 8.76 0.43 1.02e-16 Schizophrenia; LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg27170947 chr2:26402098 FAM59B -0.72 -11.04 -0.52 2.26e-24 Gut microbiome composition (summer); LUSC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.39 6.0 0.31 5.15e-9 Total body bone mineral density; LUSC cis rs12421382 0.636 rs1371329 chr11:109382725 G/T cg11473876 chr11:109292803 C11orf87 -0.41 -6.71 -0.34 8.36e-11 Schizophrenia; LUSC cis rs12579753 0.917 rs10778833 chr12:82197983 G/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs4953076 0.573 rs7602070 chr2:44388614 G/A cg04920474 chr2:44395004 PPM1B 0.62 8.02 0.4 1.79e-14 Height; LUSC cis rs9905704 0.647 rs11079367 chr17:57009024 A/G cg12560992 chr17:57184187 TRIM37 0.58 9.32 0.45 1.65e-18 Testicular germ cell tumor; LUSC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg04844267 chr4:1394941 NA 0.32 6.31 0.33 8.95e-10 Obesity-related traits; LUSC cis rs4595586 0.756 rs7137139 chr12:39364013 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.85 0.35 3.66e-11 Morning vs. evening chronotype; LUSC cis rs3931020 0.688 rs277396 chr1:75213648 A/C cg21906852 chr1:75198582 TYW3;CRYZ -0.44 -5.67 -0.3 3.15e-8 Resistin levels; LUSC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg13175981 chr1:150552382 MCL1 0.44 6.06 0.31 3.6e-9 Urate levels; LUSC cis rs68170813 0.559 rs75154004 chr7:106903326 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs6582630 0.555 rs35186318 chr12:38295822 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.35 -0.42 1.82e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs11676348 0.808 rs61700947 chr2:219046171 C/G cg00012203 chr2:219082015 ARPC2 0.59 9.44 0.46 6.77e-19 Ulcerative colitis; LUSC cis rs7267979 0.565 rs958075 chr20:25595123 C/T cg03522245 chr20:25566470 NINL -0.38 -6.0 -0.31 5.12e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4851254 0.660 rs56037757 chr2:100690130 A/G cg22139774 chr2:100720529 AFF3 -0.43 -5.75 -0.3 1.99e-8 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -8.2 -0.41 5.25e-15 Chronic sinus infection; LUSC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg04287289 chr16:89883240 FANCA -0.74 -12.05 -0.55 5.38e-28 Vitiligo; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg18765753 chr7:1198926 ZFAND2A -0.52 -9.52 -0.46 3.63e-19 Longevity;Endometriosis; LUSC trans rs867371 0.502 rs8025964 chr15:82521770 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.38 -6.08 -0.32 3.27e-9 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs8114671 0.836 rs745849 chr20:33572178 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -5.94 -0.31 6.99e-9 Height; LUSC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.39 -6.04 -0.31 4.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -10.0 -0.48 8.85e-21 Personality dimensions; LUSC trans rs853679 0.546 rs200490 chr6:27796935 G/T cg06606381 chr12:133084897 FBRSL1 -0.73 -7.26 -0.37 2.66e-12 Depression; LUSC cis rs6599077 0.950 rs9863428 chr3:40099571 T/C cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg14004847 chr7:1930337 MAD1L1 -0.45 -6.54 -0.34 2.25e-10 Bipolar disorder and schizophrenia; LUSC trans rs7824557 0.675 rs2736265 chr8:11186674 A/G cg06636001 chr8:8085503 FLJ10661 0.44 6.22 0.32 1.52e-9 Retinal vascular caliber; LUSC trans rs561341 1.000 rs56903735 chr17:30254393 T/A cg27661571 chr11:113659931 NA -0.6 -7.12 -0.36 6.47e-12 Hip circumference adjusted for BMI; LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg20887711 chr4:1340912 KIAA1530 0.7 10.79 0.51 1.76e-23 Longevity; LUSC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.29 -5.97 -0.31 6.02e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg16132339 chr22:24313637 DDTL;DDT 0.42 6.56 0.34 2.04e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg14893161 chr1:205819251 PM20D1 0.47 6.56 0.34 2.03e-10 Parkinson's disease; LUSC cis rs61931739 1.000 rs11052989 chr12:34057614 G/A cg06521331 chr12:34319734 NA 0.39 6.42 0.33 4.76e-10 Morning vs. evening chronotype; LUSC cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg16586182 chr3:47516702 SCAP 0.53 8.07 0.4 1.31e-14 Colorectal cancer; LUSC cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg13010199 chr12:38710504 ALG10B 0.62 9.23 0.45 3.2e-18 Bladder cancer; LUSC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg00908189 chr16:619842 PIGQ 0.71 11.12 0.52 1.21e-24 Height; LUSC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg18876405 chr7:65276391 NA -0.58 -9.36 -0.46 1.17e-18 Aortic root size; LUSC cis rs753307 0.512 rs749776 chr19:49519058 T/C cg20610492 chr19:49520450 LHB -0.35 -5.8 -0.3 1.58e-8 Blood protein levels; LUSC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.5 -6.96 -0.36 1.78e-11 Alzheimer's disease (late onset); LUSC cis rs1577917 1.000 rs2816821 chr6:86657084 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.37 -0.42 1.6e-15 Response to antipsychotic treatment; LUSC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg22823121 chr1:150693482 HORMAD1 0.5 7.21 0.37 3.67e-12 Melanoma; LUSC trans rs1005277 0.579 rs2474568 chr10:38383147 A/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.2 -0.45 4.01e-18 Extrinsic epigenetic age acceleration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24201109 chr6:16129407 MYLIP 0.44 6.02 0.31 4.55e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8078723 0.668 rs3859191 chr17:38128714 G/A cg17467752 chr17:38218738 THRA 0.52 7.66 0.39 2.02e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs79149102 0.579 rs6495142 chr15:75320166 C/T cg17294928 chr15:75287854 SCAMP5 -0.71 -6.51 -0.34 2.68e-10 Lung cancer; LUSC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg14019146 chr3:50243930 SLC38A3 -0.32 -7.33 -0.37 1.7e-12 Intelligence (multi-trait analysis); LUSC cis rs870825 0.655 rs28726376 chr4:185638954 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.55 0.6 1.23e-33 Blood protein levels; LUSC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg21132104 chr15:45694354 SPATA5L1 -0.54 -7.26 -0.37 2.75e-12 Homoarginine levels; LUSC trans rs2018683 0.707 rs2057957 chr7:28974626 A/C cg19402173 chr7:128379420 CALU 0.48 7.37 0.37 1.35e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.66 0.57 2.9e-30 Motion sickness; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg05457628 chr5:178986728 RUFY1 0.67 12.45 0.56 1.76e-29 Lung cancer; LUSC cis rs11583043 0.918 rs6675403 chr1:101418569 T/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.2 0.32 1.71e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs7726839 0.574 rs11134148 chr5:637107 C/T cg25482853 chr8:67687455 SGK3 1.11 15.5 0.65 3.31e-41 Obesity-related traits; LUSC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg06713675 chr4:122721982 EXOSC9 -0.46 -8.07 -0.4 1.27e-14 Type 2 diabetes; LUSC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg18904891 chr8:8559673 CLDN23 0.6 8.0 0.4 2.11e-14 Obesity-related traits; LUSC cis rs10751667 0.643 rs7942693 chr11:957832 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.13e-10 Alzheimer's disease (late onset); LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg10862848 chr6:42927986 GNMT -0.31 -7.5 -0.38 5.89e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg03806693 chr22:41940476 POLR3H 0.88 12.29 0.56 6.62e-29 Vitiligo; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg22963979 chr7:1858916 MAD1L1 -0.74 -12.73 -0.57 1.57e-30 Bipolar disorder and schizophrenia; LUSC cis rs11048434 0.736 rs11048190 chr12:9104939 C/T cg13575925 chr12:9217583 LOC144571 0.35 6.36 0.33 6.77e-10 Sjögren's syndrome; LUSC trans rs11098499 0.863 rs1383532 chr4:120434404 A/T cg25214090 chr10:38739885 LOC399744 -0.5 -7.44 -0.38 8.43e-13 Corneal astigmatism; LUSC cis rs3096299 0.679 rs3102338 chr16:89442250 C/G cg16743903 chr16:89593216 SPG7 -0.4 -5.98 -0.31 5.59e-9 Multiple myeloma (IgH translocation); LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.01 0.31 4.88e-9 Menopause (age at onset); LUSC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg17971929 chr21:40555470 PSMG1 0.63 7.61 0.38 2.83e-13 Cognitive function; LUSC cis rs7085104 0.513 rs619824 chr10:104581288 G/T cg05855489 chr10:104503620 C10orf26 0.68 11.35 0.53 1.78e-25 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6736093 0.966 rs3761699 chr2:112705290 G/A cg12686935 chr2:112915763 FBLN7 -0.36 -5.81 -0.3 1.45e-8 Coronary artery disease; LUSC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.38 -5.92 -0.31 8e-9 Alzheimer's disease (late onset); LUSC cis rs6121246 0.657 rs74392247 chr20:30241737 C/T cg13852791 chr20:30311386 BCL2L1 0.89 10.19 0.49 2.11e-21 Mean corpuscular hemoglobin; LUSC cis rs7590368 0.715 rs56263234 chr2:10959160 A/G cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs10465746 0.682 rs882897 chr1:84426049 A/T cg10977910 chr1:84465055 TTLL7 0.44 6.42 0.33 4.78e-10 Obesity-related traits; LUSC cis rs7927592 0.913 rs12285993 chr11:68302538 A/G cg16797656 chr11:68205561 LRP5 0.38 6.25 0.32 1.27e-9 Total body bone mineral density; LUSC trans rs11098499 0.644 rs3986377 chr4:120260270 G/A cg25214090 chr10:38739885 LOC399744 0.41 6.29 0.33 9.72e-10 Corneal astigmatism; LUSC cis rs1044826 1.000 rs13074208 chr3:139207151 A/G cg00490450 chr3:139108681 COPB2 0.51 6.79 0.35 5.07e-11 Obesity-related traits; LUSC cis rs4132509 0.744 rs10803156 chr1:243917776 G/C cg21452805 chr1:244014465 NA 0.56 5.69 0.3 2.78e-8 RR interval (heart rate); LUSC cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg08999081 chr20:33150536 PIGU 0.53 10.45 0.5 2.75e-22 Coronary artery disease; LUSC trans rs2797160 0.967 rs28629380 chr6:126004197 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.38 -0.33 6.05e-10 Endometrial cancer; LUSC cis rs7633770 0.786 rs1402148 chr3:46678295 C/T cg11219411 chr3:46661640 NA 0.37 7.7 0.39 1.52e-13 Coronary artery disease; LUSC cis rs2255336 0.938 rs2734414 chr12:10598802 A/T cg16084090 chr12:10586130 KLRC2 0.45 6.05 0.31 3.79e-9 Blood protein levels; LUSC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg11102782 chr19:18549136 ISYNA1 -0.35 -6.63 -0.34 1.37e-10 Breast cancer; LUSC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg12564285 chr5:131593104 PDLIM4 0.39 7.09 0.36 7.98e-12 Breast cancer; LUSC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.59 -8.91 -0.44 3.26e-17 Alzheimer's disease; LUSC cis rs1178968 1.000 rs4717756 chr7:72765458 C/G cg25889504 chr7:72793014 NA -0.56 -7.32 -0.37 1.91e-12 Triglyceride levels; LUSC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg10207240 chr12:122356781 WDR66 0.48 7.0 0.36 1.39e-11 Mean platelet volume; LUSC cis rs10911363 0.592 rs2761581 chr1:183474850 G/C cg09173681 chr1:183549694 NCF2 0.64 11.37 0.53 1.55e-25 Systemic lupus erythematosus; LUSC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.55 0.46 2.98e-19 Personality dimensions; LUSC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg12311346 chr5:56204834 C5orf35 -0.65 -10.12 -0.48 3.59e-21 Coronary artery disease; LUSC trans rs62458065 0.640 rs28587905 chr7:32533054 C/T cg00845942 chr12:64062724 DPY19L2 -0.6 -7.35 -0.37 1.5e-12 Metabolite levels (HVA/MHPG ratio); LUSC cis rs10191773 0.535 rs11123133 chr2:112965023 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.65 -8.03 -0.4 1.63e-14 Yeast infection; LUSC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg21862992 chr11:68658383 NA 0.52 8.02 0.4 1.74e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg10792982 chr14:105748885 BRF1 0.49 8.53 0.42 5.15e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC cis rs12291225 0.535 rs12806025 chr11:14413817 G/A cg19336497 chr11:14380999 RRAS2 -0.53 -11.22 -0.52 5.31e-25 Sense of smell; LUSC cis rs11608355 0.508 rs12822899 chr12:109800978 A/G cg19025524 chr12:109796872 NA -0.47 -8.45 -0.42 9.19e-16 Neuroticism; LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11958404 0.860 rs6868839 chr5:157442196 T/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs870825 0.616 rs4416519 chr4:185639502 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs4887059 1 rs4887059 chr15:78782095 C/T cg18825076 chr15:78729989 IREB2 -0.43 -6.82 -0.35 4.31e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs2905347 0.757 rs2905318 chr7:22696653 A/C cg09038599 chr8:57233391 SDR16C5 0.28 6.13 0.32 2.54e-9 Major depression and alcohol dependence; LUSC cis rs8177253 0.633 rs10935073 chr3:133439184 T/C cg11941060 chr3:133502564 NA -0.44 -6.29 -0.33 9.96e-10 Iron status biomarkers; LUSC cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs11098499 0.691 rs10010355 chr4:120261043 A/G cg24375607 chr4:120327624 NA 0.71 11.35 0.53 1.83e-25 Corneal astigmatism; LUSC cis rs2486288 0.656 rs7162022 chr15:45565253 C/T cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.65 -0.5 5.58e-23 Glomerular filtration rate; LUSC trans rs2392780 0.536 rs620808 chr8:128335714 C/T cg10195415 chr17:73887371 TRIM65 0.42 6.65 0.34 1.23e-10 Breast cancer (early onset); LUSC cis rs17270561 0.609 rs1317816 chr6:25765390 T/C cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC trans rs9291683 0.595 rs13150928 chr4:10052961 G/T cg26043149 chr18:55253948 FECH 0.48 7.05 0.36 1.04e-11 Bone mineral density; LUSC cis rs472402 0.580 rs11738248 chr5:6657494 C/T cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.53 -7.52 -0.38 5.2e-13 Response to amphetamines; LUSC cis rs79349575 0.651 rs4378658 chr17:46993370 G/A cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC trans rs4252134 0.881 rs4252107 chr6:161137518 T/C cg00639886 chr12:54943102 PDE1B -0.43 -6.17 -0.32 2.01e-9 Giant cell arteritis; LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg19266014 chr7:2183958 MAD1L1 -0.36 -6.17 -0.32 2.03e-9 Bipolar disorder and schizophrenia; LUSC cis rs7917772 0.582 rs12784963 chr10:104336986 G/A cg22532475 chr10:104410764 TRIM8 0.26 6.14 0.32 2.37e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11168618 0.810 rs35338015 chr12:48839401 C/T cg24011408 chr12:48396354 COL2A1 0.38 6.07 0.32 3.48e-9 Adiponectin levels; LUSC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg21782813 chr7:2030301 MAD1L1 0.48 8.25 0.41 3.73e-15 Bipolar disorder and schizophrenia; LUSC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.49 -0.53 5.69e-26 Schizophrenia; LUSC cis rs6456156 0.586 rs2017338 chr6:167471714 G/A cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs6460942 0.908 rs77799203 chr7:12264432 C/G cg06484146 chr7:12443880 VWDE -0.56 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg18252515 chr7:66147081 NA 1.23 14.08 0.61 1.1e-35 Diabetic kidney disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00660163 chr1:156052512 MEX3A -0.43 -6.55 -0.34 2.19e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs394563 0.601 rs439495 chr6:149793224 A/G cg11245181 chr6:149772854 ZC3H12D 0.35 7.03 0.36 1.2e-11 Dupuytren's disease; LUSC cis rs9796 0.866 rs516156 chr15:41381257 A/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -8.04 -0.4 1.55e-14 Menopause (age at onset); LUSC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg07493874 chr5:1342172 CLPTM1L -0.28 -5.87 -0.31 1.08e-8 Lung cancer; LUSC cis rs9815354 1.000 rs9856088 chr3:41860482 G/T cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.55e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs61897795 0.657 rs174589 chr11:61615803 C/G cg19610905 chr11:61596333 FADS2 0.42 5.77 0.3 1.82e-8 Neutrophil count;Sum basophil neutrophil counts; LUSC cis rs8072100 0.967 rs11656855 chr17:45714655 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.36 5.99 0.31 5.31e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg26408565 chr15:76604113 ETFA -0.43 -6.85 -0.35 3.64e-11 Blood metabolite levels; LUSC cis rs977987 0.624 rs59867374 chr16:75432682 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -6.9 -0.35 2.55e-11 Dupuytren's disease; LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs2710642 0.888 rs2539985 chr2:63134507 T/A cg17519650 chr2:63277830 OTX1 0.51 7.19 0.37 4.27e-12 LDL cholesterol levels;LDL cholesterol; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg08888203 chr3:10149979 C3orf24 0.66 9.31 0.45 1.79e-18 Alzheimer's disease; LUSC trans rs56176327 0.583 rs7613603 chr3:49812866 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.6 7.1 0.36 7.44e-12 Intelligence (multi-trait analysis); LUSC cis rs7582720 0.945 rs72934583 chr2:204009057 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 8.78 0.43 8.34e-17 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6933660 0.744 rs3800279 chr6:151766162 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.53 6.99 0.36 1.47e-11 Menarche (age at onset); LUSC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.614 rs9640655 chr7:98017099 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.72 -10.15 -0.49 2.92e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs3820068 0.705 rs951225 chr1:15826292 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.86 0.31 1.08e-8 Systolic blood pressure; LUSC cis rs11997175 0.583 rs7464599 chr8:33817572 G/A ch.8.33884649F chr8:33765107 NA 0.46 6.55 0.34 2.22e-10 Body mass index; LUSC cis rs10740039 0.883 rs10761538 chr10:62409221 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.38e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg07936489 chr17:37558343 FBXL20 -0.7 -9.98 -0.48 1.09e-20 Glomerular filtration rate (creatinine); LUSC cis rs868036 0.645 rs28539889 chr15:68121428 T/A cg08079166 chr15:68083412 MAP2K5 0.48 8.04 0.4 1.57e-14 Restless legs syndrome; LUSC cis rs2795502 0.882 rs3123754 chr10:43339011 G/A cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.57 0.38 3.69e-13 Prudent dietary pattern; LUSC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg24562669 chr7:97807699 LMTK2 0.36 6.27 0.32 1.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6121246 0.542 rs75694362 chr20:30450708 T/C cg13852791 chr20:30311386 BCL2L1 0.68 6.51 0.34 2.79e-10 Mean corpuscular hemoglobin; LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs17075286 1 rs17075286 chr3:43230723 C/G cg09326880 chr3:43147587 C3orf39 -0.48 -5.72 -0.3 2.33e-8 Bipolar disorder and schizophrenia; LUSC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.14 0.36 5.96e-12 Hip circumference adjusted for BMI; LUSC cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -7.93 -0.4 3.41e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg26384229 chr12:38710491 ALG10B 0.88 15.14 0.64 8.97e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs634534 0.562 rs642293 chr11:65730217 G/A cg17712092 chr4:129076599 LARP1B 0.72 10.86 0.51 9.8599999999999993e-24 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.96 0.7 5.97e-51 Chronic sinus infection; LUSC cis rs9650657 0.615 rs7012199 chr8:10696997 A/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.32 -0.33 8.37e-10 Neuroticism; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg06145435 chr7:1022769 CYP2W1 0.3 6.19 0.32 1.77e-9 Longevity;Endometriosis; LUSC cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.33 0.49 6.79e-22 Schizophrenia; LUSC trans rs2243480 1.000 rs73142122 chr7:65311298 C/A cg10756647 chr7:56101905 PSPH 0.88 8.45 0.42 8.8e-16 Diabetic kidney disease; LUSC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg22508957 chr16:3507546 NAT15 -0.86 -10.67 -0.5 4.52e-23 Tuberculosis; LUSC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg18825119 chr6:163149453 PACRG;PARK2 0.45 7.38 0.37 1.24e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9905704 0.647 rs6503888 chr17:57028126 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.46 -0.38 7.68e-13 Testicular germ cell tumor; LUSC cis rs3820068 0.544 rs7551750 chr1:16035008 T/C cg13390004 chr1:15929781 NA 0.41 6.79 0.35 5.02e-11 Systolic blood pressure; LUSC cis rs1371867 0.875 rs1660311 chr8:101330579 C/T cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC cis rs1577917 0.771 rs2842612 chr6:86303091 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.67 -0.43 1.93e-16 Response to antipsychotic treatment; LUSC trans rs7647973 0.710 rs11130208 chr3:49615624 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 6.98e-13 Menarche (age at onset); LUSC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg11764359 chr7:65958608 NA 0.79 12.71 0.57 1.81e-30 Aortic root size; LUSC trans rs61931739 0.635 rs4442626 chr12:33912530 C/T cg13010199 chr12:38710504 ALG10B 0.41 6.12 0.32 2.65e-9 Morning vs. evening chronotype; LUSC cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.85 0.7 1.69e-50 Chronic sinus infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04869497 chr17:20059225 CYTSB 0.48 6.49 0.33 3.08e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg04546413 chr19:29218101 NA 0.74 12.95 0.58 2.35e-31 Methadone dose in opioid dependence; LUSC cis rs9303401 0.659 rs35928756 chr17:56702652 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.55e-35 Cognitive test performance; LUSC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg24060327 chr5:131705240 SLC22A5 -0.5 -8.44 -0.42 1e-15 Breast cancer; LUSC cis rs11792861 0.781 rs11793272 chr9:111762102 G/A cg05043794 chr9:111880884 C9orf5 -0.38 -7.85 -0.39 5.79e-14 Menarche (age at onset); LUSC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg12386194 chr3:101231763 SENP7 0.53 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg08645402 chr16:4508243 NA 0.51 8.04 0.4 1.6e-14 Schizophrenia; LUSC cis rs10754283 0.967 rs10801757 chr1:90103080 A/G cg21401794 chr1:90099060 LRRC8C 0.63 9.61 0.47 1.84e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg19077165 chr18:44547161 KATNAL2 -0.43 -6.4 -0.33 5.2400000000000005e-10 Personality dimensions; LUSC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg26335602 chr6:28129616 ZNF389 0.43 5.8 0.3 1.54e-8 Depression; LUSC cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg05855489 chr10:104503620 C10orf26 0.64 9.26 0.45 2.47e-18 Arsenic metabolism; LUSC cis rs7819412 0.668 rs4841507 chr8:11046394 C/G cg21775007 chr8:11205619 TDH -0.49 -6.89 -0.35 2.85e-11 Triglycerides; LUSC cis rs6424115 1.000 rs6697805 chr1:24151996 C/A cg15997130 chr1:24165203 NA -0.54 -8.79 -0.43 7.79e-17 Immature fraction of reticulocytes; LUSC cis rs2299587 0.560 rs12718385 chr8:17781257 T/C cg01800426 chr8:17659068 MTUS1 -0.49 -6.53 -0.34 2.4e-10 Economic and political preferences; LUSC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg14949292 chr17:78079608 GAA 0.33 5.71 0.3 2.54e-8 Yeast infection; LUSC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.06 0.44 1.1e-17 Total body bone mineral density; LUSC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg11663144 chr21:46675770 NA -0.41 -7.29 -0.37 2.3e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6690583 0.524 rs12045710 chr1:85451765 T/C cg22153463 chr1:85462885 MCOLN2 0.62 6.0 0.31 5.12e-9 Serum sulfate level; LUSC cis rs7572644 0.699 rs10175508 chr2:28213424 C/T cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7605827 0.866 rs2276664 chr2:15701002 A/T cg19274914 chr2:15703543 NA 0.46 8.64 0.43 2.33e-16 Educational attainment (years of education); LUSC trans rs6598955 0.671 rs12090258 chr1:26644698 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.31 -0.41 2.44e-15 Obesity-related traits; LUSC cis rs7809950 0.817 rs2204833 chr7:107283069 T/C cg23024343 chr7:107201750 COG5 0.62 8.71 0.43 1.43e-16 Coronary artery disease; LUSC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.23 -0.32 1.39e-9 Neutrophil percentage of white cells; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg07806771 chr7:64541737 NA 0.42 5.99 0.31 5.43e-9 Calcium levels; LUSC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg22875332 chr1:76189707 ACADM 0.85 15.67 0.65 6.91e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7954584 0.604 rs34159444 chr12:122416667 A/G cg21171335 chr12:122356390 WDR66 0.62 9.33 0.45 1.51e-18 Mean corpuscular volume; LUSC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.63e-10 Life satisfaction; LUSC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg04287289 chr16:89883240 FANCA -0.42 -6.06 -0.31 3.61e-9 Vitiligo; LUSC cis rs73206853 0.698 rs56327628 chr12:111117931 A/C cg12870014 chr12:110450643 ANKRD13A 0.67 6.85 0.35 3.6e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg26727032 chr16:67993705 SLC12A4 -0.44 -5.87 -0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs2692947 0.770 rs2315421 chr2:96497516 G/C cg23100626 chr2:96804247 ASTL 0.26 6.47 0.33 3.53e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs477692 0.905 rs576560 chr10:131420697 C/A cg26102564 chr10:131424627 MGMT 0.36 5.69 0.3 2.74e-8 Response to temozolomide; LUSC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Urate levels; LUSC cis rs10193935 0.901 rs6727657 chr2:42632117 A/G cg27598129 chr2:42591480 NA -0.6 -8.17 -0.41 6.63e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs4332037 0.906 rs6461009 chr7:1952139 T/C cg23422044 chr7:1970798 MAD1L1 0.63 7.34 0.37 1.63e-12 Bipolar disorder; LUSC cis rs11690935 0.569 rs62183770 chr2:172838117 C/G cg13550731 chr2:172543902 DYNC1I2 0.5 7.44 0.38 8.64e-13 Schizophrenia; LUSC trans rs853679 0.607 rs67101035 chr6:27798887 C/G cg06606381 chr12:133084897 FBRSL1 -1.0 -8.84 -0.44 5.76e-17 Depression; LUSC cis rs17001868 0.568 rs9611328 chr22:40791972 C/T cg07138101 chr22:40742427 ADSL 0.6 7.39 0.37 1.21e-12 Mammographic density (dense area); LUSC cis rs9581857 0.685 rs9319370 chr13:28042493 G/T cg22138327 chr13:27999177 GTF3A 0.74 8.04 0.4 1.53e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg18230493 chr5:56204884 C5orf35 -0.58 -9.36 -0.46 1.22e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs7923609 0.967 rs7085621 chr10:65208926 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.03e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs34421088 0.532 rs3808515 chr8:11156041 C/T cg15556689 chr8:8085844 FLJ10661 0.41 6.08 0.32 3.23e-9 Neuroticism; LUSC cis rs7582180 0.614 rs3748930 chr2:101010082 G/C cg08017756 chr2:100939284 LONRF2 -0.43 -8.06 -0.4 1.4e-14 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 9.57 0.46 2.51e-19 Menopause (age at onset); LUSC cis rs10875746 0.903 rs11168427 chr12:48538979 A/G cg13454099 chr12:49076203 C12orf41 -0.52 -6.15 -0.32 2.17e-9 Longevity (90 years and older); LUSC cis rs7481584 0.581 rs406598 chr11:3076285 G/A cg05729581 chr11:3078854 CARS 0.4 5.82 0.3 1.36e-8 Calcium levels; LUSC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg21361702 chr7:150065534 REPIN1 0.52 6.73 0.35 7.29e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg04111992 chr7:158790115 NA -0.38 -5.87 -0.31 1.03e-8 Facial morphology (factor 20); LUSC cis rs34779708 0.931 rs7099593 chr10:35366878 A/C cg03585969 chr10:35415529 CREM 0.59 8.83 0.44 6.06e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7106204 0.686 rs12791623 chr11:24277924 A/T ch.11.24196551F chr11:24239977 NA 0.73 6.0 0.31 5.01e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6430585 0.528 rs79826902 chr2:136670419 G/A cg07169764 chr2:136633963 MCM6 1.14 17.51 0.69 3.64e-49 Corneal structure; LUSC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs4853012 0.752 rs13413795 chr2:74349839 G/A cg05776053 chr2:74358815 NA 0.46 7.24 0.37 3.06e-12 Gestational age at birth (maternal effect); LUSC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11890956 chr21:40555474 PSMG1 -0.71 -11.09 -0.52 1.47e-24 Menarche (age at onset); LUSC trans rs9388451 0.626 rs1739384 chr6:126099246 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.73 -12.68 -0.57 2.33e-30 Brugada syndrome; LUSC cis rs2795502 0.882 rs2744087 chr10:43340270 A/C cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg11812906 chr14:75593930 NEK9 -0.64 -10.47 -0.5 2.32e-22 Height; LUSC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg08847533 chr14:75593920 NEK9 -0.79 -13.55 -0.6 1.25e-33 Height; LUSC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg21285383 chr16:89894308 SPIRE2 0.31 6.58 0.34 1.79e-10 Vitiligo; LUSC cis rs9326248 0.559 rs609177 chr11:116770517 A/G cg26566898 chr11:117069891 TAGLN 0.38 7.23 0.37 3.4e-12 Blood protein levels; LUSC cis rs17270561 0.636 rs6923367 chr6:25745852 A/T cg17691542 chr6:26056736 HIST1H1C 0.59 8.19 0.41 5.46e-15 Iron status biomarkers; LUSC cis rs7980687 0.574 rs10744149 chr12:123708490 T/A cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs4555082 0.915 rs28594491 chr14:105758018 G/A cg06808227 chr14:105710500 BRF1 -0.64 -9.77 -0.47 5.53e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs11039100 1.000 rs12362696 chr11:5828034 G/A cg13902645 chr11:5959945 NA -0.52 -5.84 -0.3 1.25e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg08975724 chr8:8085496 FLJ10661 -0.54 -8.04 -0.4 1.62e-14 Mood instability; LUSC cis rs55665837 1.000 rs11023229 chr11:14461001 G/C cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 6.93e-13 Vitamin D levels; LUSC trans rs12188164 0.686 rs56279338 chr5:416118 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.42 6.55 0.34 2.21e-10 Cystic fibrosis severity; LUSC cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg08999081 chr20:33150536 PIGU 0.53 10.45 0.5 2.74e-22 Glomerular filtration rate (creatinine); LUSC cis rs6840360 0.571 rs4696102 chr4:152529658 C/T cg22705602 chr4:152727874 NA -0.32 -6.42 -0.33 4.59e-10 Intelligence (multi-trait analysis); LUSC cis rs6740322 0.748 rs6544634 chr2:43471528 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -6.53 -0.34 2.45e-10 Coronary artery disease; LUSC cis rs1670533 0.932 rs610218 chr4:1080083 C/G cg02018176 chr4:1364513 KIAA1530 0.45 6.29 0.33 9.9e-10 Recombination rate (females); LUSC cis rs11122272 0.735 rs2491408 chr1:231519248 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7147624 0.882 rs7141367 chr14:65938641 C/T cg03016385 chr14:66212404 NA -0.84 -9.36 -0.46 1.19e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4654899 0.802 rs6685306 chr1:21219050 C/T cg02927042 chr1:21476669 EIF4G3 -0.39 -6.01 -0.31 4.79e-9 Superior frontal gyrus grey matter volume; LUSC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg20821713 chr7:1055600 C7orf50 -0.53 -6.93 -0.35 2.13e-11 Bronchopulmonary dysplasia; LUSC cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg03146154 chr1:46216737 IPP -0.58 -8.39 -0.42 1.37e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg15704280 chr7:45808275 SEPT13 -0.57 -6.98 -0.36 1.64e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg21724239 chr8:58056113 NA 0.61 6.83 0.35 4.08e-11 Developmental language disorder (linguistic errors); LUSC trans rs7826238 0.566 rs2945886 chr8:8148270 C/G cg27411982 chr8:10470053 RP1L1 0.39 6.0 0.31 5.28e-9 Systolic blood pressure; LUSC trans rs9329221 0.662 rs4240645 chr8:10254463 C/G cg08975724 chr8:8085496 FLJ10661 -0.46 -5.96 -0.31 6.26e-9 Neuroticism; LUSC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.86 0.54 2.59e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg25358565 chr5:93447407 FAM172A 1.01 13.19 0.59 2.99e-32 Diabetic retinopathy; LUSC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.97 0.48 1.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.754 rs878372 chr4:120238780 A/C cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC cis rs34375054 0.525 rs7136220 chr12:125602684 T/C cg09839279 chr12:125627357 AACS -0.32 -5.66 -0.3 3.18e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg15744005 chr10:104629667 AS3MT -0.28 -5.9 -0.31 8.93e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg13393036 chr8:95962371 TP53INP1 -0.46 -9.98 -0.48 1.03e-20 Type 2 diabetes; LUSC cis rs9815354 0.812 rs73073355 chr3:41842332 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg20476274 chr7:133979776 SLC35B4 -0.8 -14.64 -0.63 7.44e-38 Mean platelet volume; LUSC cis rs78456975 1.000 rs10208340 chr2:1563100 G/A cg12573674 chr2:1569213 NA -0.55 -6.09 -0.32 3.04e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7577696 0.925 rs12617290 chr2:32341408 A/G cg02381751 chr2:32503542 YIPF4 -0.39 -5.66 -0.3 3.25e-8 Inflammatory biomarkers; LUSC cis rs11229555 0.645 rs7117080 chr11:58178677 C/G cg15696309 chr11:58395628 NA -0.6 -7.48 -0.38 6.71e-13 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs36093844 0.800 rs112468922 chr11:85576694 A/G cg16165120 chr11:85566439 CCDC83 -0.4 -5.82 -0.3 1.41e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs7481584 0.624 rs412842 chr11:3047448 A/G cg05729581 chr11:3078854 CARS 0.4 5.86 0.31 1.11e-8 Calcium levels; LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg10802521 chr3:52805072 NEK4 -0.54 -8.89 -0.44 3.84e-17 Bipolar disorder; LUSC cis rs2839186 0.872 rs13046834 chr21:47701485 T/C cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.06e-9 Testicular germ cell tumor; LUSC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.42 -0.33 4.6e-10 Total body bone mineral density; LUSC cis rs3096299 0.685 rs4785568 chr16:89553707 A/G cg02187348 chr16:89574699 SPG7 0.63 10.39 0.49 4.39e-22 Multiple myeloma (IgH translocation); LUSC trans rs12310956 0.532 rs10844719 chr12:33987714 A/G cg13010199 chr12:38710504 ALG10B 0.52 7.75 0.39 1.1e-13 Morning vs. evening chronotype; LUSC cis rs4664304 0.903 rs72957578 chr2:160754133 G/C cg03641300 chr2:160917029 PLA2R1 -0.4 -6.48 -0.33 3.26e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9467711 0.606 rs9379863 chr6:26372427 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7100689 0.577 rs756208 chr10:82041751 A/G cg00277334 chr10:82204260 NA -0.46 -6.53 -0.34 2.47e-10 Post bronchodilator FEV1; LUSC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg00745463 chr17:30367425 LRRC37B -0.7 -8.52 -0.42 5.45e-16 Hip circumference adjusted for BMI; LUSC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg24060327 chr5:131705240 SLC22A5 -0.48 -8.44 -0.42 9.46e-16 Blood metabolite levels; LUSC cis rs4595586 0.545 rs969469 chr12:39366775 A/C cg26384229 chr12:38710491 ALG10B 0.5 7.17 0.37 4.75e-12 Morning vs. evening chronotype; LUSC cis rs559928 0.606 rs57021319 chr11:63956102 G/A cg05555928 chr11:63887634 MACROD1 -0.5 -6.1 -0.32 2.93e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs12950390 0.853 rs11658511 chr17:45856918 T/C cg03474202 chr17:45855739 NA -0.29 -6.7 -0.34 8.99e-11 IgG glycosylation; LUSC cis rs7296418 0.961 rs1790122 chr12:123606739 G/A cg13010344 chr12:123464640 ARL6IP4 -0.52 -8.11 -0.41 1e-14 Platelet count; LUSC cis rs10992471 0.603 rs11788523 chr9:95256593 G/A cg14631576 chr9:95140430 CENPP -0.33 -5.96 -0.31 6.48e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg24399712 chr22:39784796 NA 0.54 8.81 0.43 7.17e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg15595755 chr5:1867978 NA 0.46 8.29 0.41 2.86e-15 Cardiovascular disease risk factors; LUSC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.65 5.68 0.3 2.87e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg03576123 chr11:487126 PTDSS2 -1.13 -11.88 -0.55 2.15e-27 Body mass index; LUSC cis rs3760982 0.813 rs8111664 chr19:44295092 G/A cg11993925 chr19:44307056 LYPD5 -0.31 -6.79 -0.35 5.11e-11 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs1459104 0.714 rs35789111 chr11:54926634 C/G cg15704280 chr7:45808275 SEPT13 0.74 6.28 0.32 1.04e-9 Body mass index; LUSC cis rs9807989 0.773 rs72823661 chr2:102968716 G/A cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC cis rs2067615 0.560 rs4964485 chr12:107121952 A/G cg15890332 chr12:107067104 RFX4 0.34 6.15 0.32 2.22e-9 Heart rate; LUSC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg06022373 chr22:39101656 GTPBP1 -0.8 -12.6 -0.57 4.65e-30 Menopause (age at onset); LUSC cis rs2294693 0.853 rs9296350 chr6:40977623 G/A cg14418226 chr6:40996092 UNC5CL 0.42 5.89 0.31 9.38e-9 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg20476274 chr7:133979776 SLC35B4 0.88 16.77 0.68 3.06e-46 Mean platelet volume; LUSC cis rs80130819 0.515 rs72644846 chr12:48508283 A/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.19 -0.32 1.72e-9 Prostate cancer; LUSC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9902453 0.904 rs9900112 chr17:28282910 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.57 0.5 1.03e-22 Coffee consumption (cups per day); LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs62432291 0.681 rs2501176 chr6:159655383 A/G cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.19 0.37 4.23e-12 Mean platelet volume; LUSC cis rs9419702 0.538 rs9322837 chr10:133539229 G/A cg04492858 chr10:133558786 NA 0.42 6.98 0.36 1.57e-11 Survival in rectal cancer; LUSC cis rs3768617 0.510 rs10752895 chr1:183068505 C/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.74 0.51 2.65e-23 Fuchs's corneal dystrophy; LUSC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg03517284 chr6:25882590 NA -0.43 -7.44 -0.38 8.75e-13 Intelligence (multi-trait analysis); LUSC cis rs7481584 0.624 rs369461 chr11:3061992 A/G cg08508325 chr11:3079039 CARS 0.38 8.54 0.42 4.96e-16 Calcium levels; LUSC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg06219351 chr7:158114137 PTPRN2 -0.53 -9.49 -0.46 4.53e-19 Calcium levels; LUSC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg05802129 chr4:122689817 NA -0.46 -8.14 -0.41 8.14e-15 Type 2 diabetes; LUSC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg18681998 chr4:17616180 MED28 0.85 15.97 0.66 4.86e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2404602 0.692 rs2137307 chr15:77149020 T/A cg22467129 chr15:76604101 ETFA -0.44 -7.02 -0.36 1.21e-11 Blood metabolite levels; LUSC cis rs1160297 0.576 rs12713233 chr2:53116767 T/A cg07782112 chr2:53107842 NA 0.45 7.32 0.37 1.81e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs1577917 1.000 rs7766645 chr6:86622238 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs6456156 0.586 rs6456150 chr6:167468922 A/G cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg01879757 chr17:41196368 BRCA1 -0.39 -5.83 -0.3 1.32e-8 Menopause (age at onset); LUSC trans rs17039065 1.000 rs72889382 chr4:109391564 A/C cg07444054 chr2:108107501 NA 0.42 6.17 0.32 1.93e-9 Gut microbiome composition (summer); LUSC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg04398451 chr17:18023971 MYO15A -0.48 -7.72 -0.39 1.34e-13 Total body bone mineral density; LUSC cis rs7829975 0.782 rs6990746 chr8:8547811 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.86 -0.4 5.34e-14 Mood instability; LUSC cis rs2996428 0.667 rs17412654 chr1:3758493 T/C cg23277830 chr1:3704460 LRRC47 0.35 6.48 0.33 3.3e-10 Red cell distribution width; LUSC cis rs7193541 0.646 rs4888267 chr16:74687906 A/G cg01733217 chr16:74700730 RFWD3 0.97 22.15 0.77 1.61e-67 Multiple myeloma; LUSC cis rs6539267 0.741 rs2279759 chr12:106694988 T/C cg02476566 chr12:106696527 TCP11L2 0.53 6.74 0.35 6.82e-11 Tourette syndrome; LUSC cis rs10886558 0.502 rs12573567 chr10:121825731 T/G cg02041677 chr10:121771263 NA -0.34 -6.14 -0.32 2.31e-9 Shingles; LUSC cis rs2274273 0.805 rs10131926 chr14:55713246 T/C cg04306507 chr14:55594613 LGALS3 0.58 13.72 0.6 2.79e-34 Protein biomarker; LUSC cis rs7617773 0.817 rs4131362 chr3:48329036 A/C cg11946769 chr3:48343235 NME6 0.86 13.87 0.6 7.36e-35 Coronary artery disease; LUSC cis rs1595825 0.891 rs3851979 chr2:198707638 A/T cg00982548 chr2:198649783 BOLL 0.57 7.25 0.37 2.89e-12 Ulcerative colitis; LUSC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.9 0.44 3.53e-17 Menopause (age at onset); LUSC trans rs3774749 0.565 rs1005678 chr3:50210289 C/G cg21659725 chr3:3221576 CRBN 0.48 7.21 0.37 3.83e-12 Intelligence (multi-trait analysis); LUSC cis rs7712401 0.601 rs62377424 chr5:122332322 G/A cg19077854 chr5:122220652 SNX24 -0.43 -9.2 -0.45 4.07e-18 Mean platelet volume; LUSC cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14240646 chr10:27532245 ACBD5 -0.66 -8.46 -0.42 8.79e-16 Breast cancer; LUSC cis rs6542838 0.588 rs4851175 chr2:99530118 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.63 -0.34 1.35e-10 Fear of minor pain; LUSC trans rs62458065 0.850 rs28677012 chr7:32469811 C/A cg00845942 chr12:64062724 DPY19L2 -0.52 -6.11 -0.32 2.84e-9 Metabolite levels (HVA/MHPG ratio); LUSC trans rs8002861 0.967 rs9525871 chr13:44477712 A/T cg12856521 chr11:46389249 DGKZ 0.4 6.13 0.32 2.54e-9 Leprosy; LUSC cis rs6692729 0.931 rs1296171 chr1:227059606 C/G cg10327440 chr1:227177885 CDC42BPA 0.49 7.09 0.36 8.19e-12 Electrodermal activity; LUSC cis rs6445797 0.603 rs11706624 chr3:56584341 T/C cg13792233 chr3:56591045 CCDC66 0.4 5.68 0.3 2.93e-8 Gastritis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25998680 chr6:43044239 PTK7 -0.4 -5.97 -0.31 6.14e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4622329 0.615 rs6539016 chr12:102290237 A/T cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC cis rs7727544 0.606 rs17622208 chr5:131717050 G/A cg18758796 chr5:131593413 PDLIM4 0.35 5.78 0.3 1.69e-8 Blood metabolite levels; LUSC cis rs7586879 0.796 rs10187348 chr2:25078415 G/C cg01884057 chr2:25150051 NA 0.38 7.89 0.4 4.27e-14 Body mass index; LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg07507251 chr3:52567010 NT5DC2 0.34 6.55 0.34 2.21e-10 Bipolar disorder; LUSC cis rs17401966 0.522 rs912962 chr1:10348712 G/T cg19773385 chr1:10388646 KIF1B 0.35 6.06 0.31 3.71e-9 Hepatocellular carcinoma; LUSC cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14442939 chr10:27389572 ANKRD26 -0.88 -9.89 -0.48 2.12e-20 Breast cancer; LUSC cis rs4285028 0.731 rs2877561 chr3:121712051 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.57 7.43 0.38 8.99e-13 Multiple sclerosis; LUSC cis rs77633900 0.614 rs12442966 chr15:76918290 G/T cg21673338 chr15:77095150 SCAPER 0.68 6.87 0.35 3.17e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg19346786 chr7:2764209 NA -0.37 -6.35 -0.33 6.96e-10 Height; LUSC cis rs9902453 0.765 rs2874505 chr17:28037923 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.3 0.53 2.74e-25 Coffee consumption (cups per day); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07600127 chr13:30881527 KATNAL1 0.44 6.05 0.31 3.85e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28830936 1.000 rs17734856 chr15:42045160 T/C cg17847044 chr15:42102381 MAPKBP1 -0.28 -5.99 -0.31 5.38e-9 Diastolic blood pressure; LUSC cis rs4478858 0.735 rs11582342 chr1:31810681 A/G cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3862435 0.706 rs12594352 chr15:91002657 A/G cg22089800 chr15:90895588 ZNF774 0.56 5.98 0.31 5.66e-9 Response to exercise (triglyceride level interaction); LUSC trans rs9291683 0.588 rs12506364 chr4:10023448 C/T cg26043149 chr18:55253948 FECH 0.51 7.52 0.38 5.1e-13 Bone mineral density; LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.76 -9.7 -0.47 9.44e-20 Gut microbiome composition (summer); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg20063963 chr1:204951166 NFASC 0.37 5.96 0.31 6.34e-9 Neuroticism; LUSC cis rs2130392 0.926 rs7677893 chr4:185625523 T/C cg04058563 chr4:185651563 MLF1IP 0.44 7.15 0.36 5.56e-12 Kawasaki disease; LUSC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg23719950 chr11:63933701 MACROD1 -0.38 -5.8 -0.3 1.55e-8 Platelet count; LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg10802521 chr3:52805072 NEK4 -0.56 -9.11 -0.45 7.82e-18 Bipolar disorder; LUSC cis rs950776 0.518 rs3813572 chr15:78832588 T/C cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs62400317 0.859 rs12214749 chr6:45307906 A/G cg20913747 chr6:44695427 NA -0.47 -7.72 -0.39 1.35e-13 Total body bone mineral density; LUSC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg15649852 chr7:65879115 NA -0.41 -5.64 -0.3 3.53e-8 Aortic root size; LUSC cis rs11785400 1.000 rs6997771 chr8:143747752 T/G cg24634471 chr8:143751801 JRK 0.59 8.88 0.44 4.09e-17 Schizophrenia; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs3849570 1.000 rs3772883 chr3:81802802 C/T cg07356753 chr3:81810745 GBE1 -0.57 -9.04 -0.44 1.29e-17 Waist circumference;Body mass index; LUSC cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg16850897 chr7:100343110 ZAN -0.62 -8.65 -0.43 2.16e-16 Other erythrocyte phenotypes; LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg08859206 chr1:53392774 SCP2 0.55 9.48 0.46 5.03e-19 Monocyte count; LUSC cis rs113835537 0.935 rs3867133 chr11:66451962 A/G cg24851651 chr11:66362959 CCS -0.46 -5.96 -0.31 6.26e-9 Airway imaging phenotypes; LUSC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg08392591 chr16:89556376 ANKRD11 0.44 6.58 0.34 1.86e-10 Multiple myeloma (IgH translocation); LUSC cis rs6484504 0.576 rs208066 chr11:31156206 C/G cg26647111 chr11:31128758 NA -0.42 -6.16 -0.32 2.08e-9 Red blood cell count; LUSC trans rs7647973 0.667 rs6446286 chr3:49681704 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.87 -0.35 3.11e-11 Menarche (age at onset); LUSC cis rs11122272 0.638 rs2739514 chr1:231514806 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.77 -0.47 5.55e-20 Hemoglobin concentration; LUSC cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.29 6.02 0.31 4.65e-9 Hemoglobin concentration; LUSC cis rs4704187 0.687 rs1363577 chr5:74463185 T/G cg03227963 chr5:74354835 NA 0.32 6.83 0.35 4.02e-11 Response to amphetamines; LUSC cis rs7173743 0.756 rs7169511 chr15:79128665 T/C cg00540400 chr15:79124168 NA 0.35 5.99 0.31 5.29e-9 Coronary artery disease; LUSC cis rs2108225 0.934 rs2283045 chr7:107440714 G/A cg18560240 chr7:107437656 SLC26A3 -0.39 -5.96 -0.31 6.42e-9 Ulcerative colitis; LUSC cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg01689657 chr7:91764605 CYP51A1 0.33 6.03 0.31 4.29e-9 Breast cancer; LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 8.36 0.42 1.68e-15 Personality dimensions; LUSC cis rs17784882 0.521 rs11713693 chr3:47074906 T/C cg16586182 chr3:47516702 SCAP 0.49 7.21 0.37 3.72e-12 QT interval; LUSC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg02931644 chr1:25747376 RHCE -0.37 -6.94 -0.36 2.04e-11 Plateletcrit;Mean corpuscular volume; LUSC cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg06671706 chr8:8559999 CLDN23 0.49 6.52 0.34 2.66e-10 Obesity-related traits; LUSC cis rs6840360 0.615 rs12641441 chr4:152607623 A/G cg22705602 chr4:152727874 NA -0.37 -7.97 -0.4 2.51e-14 Intelligence (multi-trait analysis); LUSC cis rs30380 0.632 rs26497 chr5:96138767 T/C cg16492584 chr5:96139282 ERAP1 -0.57 -7.72 -0.39 1.33e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg05623727 chr3:50126028 RBM5 -0.33 -6.17 -0.32 1.99e-9 Intelligence (multi-trait analysis); LUSC cis rs4891159 0.790 rs35516239 chr18:74129942 C/T cg24786174 chr18:74118243 ZNF516 -0.83 -15.3 -0.64 2.07e-40 Longevity; LUSC cis rs7089973 0.668 rs7077148 chr10:116644896 A/G cg03647239 chr10:116582469 FAM160B1 0.41 6.18 0.32 1.86e-9 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2486288 0.656 rs8039153 chr15:45579813 T/C cg26924012 chr15:45694286 SPATA5L1 -0.75 -10.95 -0.51 4.72e-24 Glomerular filtration rate; LUSC cis rs1577917 0.740 rs2475792 chr6:86392102 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 9.71 0.47 8.25e-20 Response to antipsychotic treatment; LUSC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg10556349 chr10:835070 NA 0.55 6.21 0.32 1.53e-9 Eosinophil percentage of granulocytes; LUSC cis rs6582630 0.615 rs11182380 chr12:38511735 G/T cg26384229 chr12:38710491 ALG10B -0.55 -8.27 -0.41 3.33e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs1348850 0.597 rs13014417 chr2:178417835 T/G cg23306229 chr2:178417860 TTC30B 0.62 7.24 0.37 3.12e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11167764 1.000 rs10057309 chr5:141479870 T/C cg23435118 chr5:141488016 NDFIP1 -0.55 -7.94 -0.4 3.14e-14 Crohn's disease; LUSC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg16240275 chr20:61666158 NCRNA00029 -0.28 -5.95 -0.31 6.9e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs36093844 0.800 rs17817355 chr11:85599945 C/A cg25872744 chr11:85566296 CCDC83 -0.44 -5.65 -0.3 3.35e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs7615316 0.528 rs13078890 chr3:142350044 T/C cg16271453 chr3:142027066 XRN1 -0.45 -7.92 -0.4 3.56e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg05738196 chr6:26577821 NA -0.53 -7.93 -0.4 3.34e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs3126085 0.877 rs6662450 chr1:152191709 C/G cg03465714 chr1:152285911 FLG -0.41 -5.89 -0.31 9.28e-9 Atopic dermatitis; LUSC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg11941060 chr3:133502564 NA -0.42 -6.12 -0.32 2.68e-9 Iron status biomarkers; LUSC cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.22 -0.41 4.4e-15 Body mass index; LUSC cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg20503657 chr10:835505 NA 0.91 12.5 0.56 1.16e-29 Eosinophil percentage of granulocytes; LUSC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg12311346 chr5:56204834 C5orf35 -0.89 -12.72 -0.57 1.75e-30 Initial pursuit acceleration; LUSC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.86e-11 Aortic root size; LUSC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg04518342 chr5:131593106 PDLIM4 0.36 6.53 0.34 2.44e-10 Blood metabolite levels; LUSC cis rs7589342 0.929 rs6719896 chr2:106428404 C/G cg14210321 chr2:106509881 NCK2 0.55 8.41 0.42 1.23e-15 Addiction; LUSC cis rs77741769 0.700 rs2701184 chr12:121353088 T/G cg02403541 chr12:121454288 C12orf43 0.44 6.62 0.34 1.45e-10 Mean corpuscular volume; LUSC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg04398451 chr17:18023971 MYO15A 0.57 9.41 0.46 8.44e-19 Total body bone mineral density; LUSC cis rs7177699 0.550 rs4468572 chr15:79124475 C/T cg00540400 chr15:79124168 NA -0.39 -6.95 -0.36 1.96e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg03678062 chr6:149772716 ZC3H12D 0.33 6.83 0.35 4.02e-11 Dupuytren's disease; LUSC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg09021430 chr5:549028 NA -0.57 -7.78 -0.39 9.19e-14 Obesity-related traits; LUSC trans rs61931739 0.534 rs12372557 chr12:34363843 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.31 0.49 7.81e-22 Morning vs. evening chronotype; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg26354017 chr1:205819088 PM20D1 0.96 20.05 0.74 3.02e-59 Menarche (age at onset); LUSC cis rs1577917 1.000 rs12190604 chr6:86716215 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.87 -0.35 3.06e-11 Response to antipsychotic treatment; LUSC cis rs12760731 0.623 rs10913536 chr1:178315257 G/A cg00404053 chr1:178313656 RASAL2 0.47 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs78572108 0.800 rs4952574 chr2:42263822 T/C cg00607755 chr2:42274082 PKDCC 0.36 6.48 0.33 3.34e-10 Total body bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01744215 chr16:9056616 USP7 0.85 6.61 0.34 1.49e-10 Cognitive performance; LUSC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg12560992 chr17:57184187 TRIM37 0.88 16.79 0.68 2.54e-46 Intelligence (multi-trait analysis); LUSC cis rs55871839 0.643 rs10109566 chr8:59800446 A/G cg07426533 chr8:59803705 TOX -0.36 -5.72 -0.3 2.36e-8 Pneumonia; LUSC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg07701084 chr6:150067640 NUP43 0.51 7.48 0.38 6.59e-13 Lung cancer; LUSC cis rs1483890 0.723 rs2007578 chr3:69408982 T/A cg22125112 chr3:69402811 FRMD4B 0.4 5.67 0.3 3.06e-8 Resting heart rate; LUSC cis rs10740039 0.842 rs7090892 chr10:62411851 A/C cg18175470 chr10:62150864 ANK3 -0.46 -6.79 -0.35 5.04e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg20295408 chr7:1910781 MAD1L1 -0.48 -6.72 -0.35 7.63e-11 Schizophrenia; LUSC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10072221 0.836 rs10462540 chr5:75703257 G/A cg03132911 chr5:75698732 IQGAP2 0.38 6.43 0.33 4.49e-10 Mean platelet volume; LUSC cis rs9303401 0.659 rs17822807 chr17:56687190 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.12 0.58 5.22e-32 Cognitive test performance; LUSC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg18876405 chr7:65276391 NA 0.77 13.78 0.6 1.58e-34 Calcium levels; LUSC cis rs1728785 0.901 rs1631910 chr16:68603335 G/A cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08354699 chr15:63796895 USP3 0.43 6.51 0.34 2.7e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.3 0.69 2.6e-48 Chronic sinus infection; LUSC cis rs9875589 0.509 rs1844107 chr3:14065319 C/G cg19554555 chr3:13937349 NA -0.38 -5.71 -0.3 2.47e-8 Ovarian reserve; LUSC cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.51 0.5 1.69e-22 Schizophrenia; LUSC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9811920 0.809 rs1384062 chr3:99597928 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 7.44 0.38 8.62e-13 Axial length; LUSC cis rs7408868 0.908 rs45591935 chr19:15277006 T/C cg14696996 chr19:15285081 NOTCH3 0.99 9.07 0.44 1.06e-17 Pulse pressure; LUSC trans rs459571 0.916 rs467303 chr9:136904835 C/T cg10765909 chr12:53715428 AAAS -0.43 -6.22 -0.32 1.47e-9 Platelet distribution width; LUSC cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -8.93 -0.44 2.82e-17 Chronic sinus infection; LUSC cis rs12368653 0.666 rs1050045 chr12:58115271 A/G cg12615879 chr12:58013172 SLC26A10 0.36 8.41 0.42 1.23e-15 Multiple sclerosis; LUSC cis rs7246967 0.673 rs7249685 chr19:22882379 C/T cg23217946 chr19:22817039 ZNF492 0.41 5.66 0.3 3.22e-8 Bronchopulmonary dysplasia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03016446 chr10:74386166 CBARA1 0.39 6.31 0.33 8.8e-10 Triglycerides; LUSC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg05373962 chr22:49881684 NA -0.44 -10.74 -0.51 2.5e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3820928 0.839 rs10197773 chr2:227824835 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.58 -0.38 3.41e-13 Pulmonary function; LUSC cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg03146154 chr1:46216737 IPP 0.53 7.75 0.39 1.09e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2625529 0.607 rs2912231 chr15:72567957 G/T cg16672083 chr15:72433130 SENP8 -0.46 -6.7 -0.34 8.67e-11 Red blood cell count; LUSC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.48 -6.44 -0.33 4.09e-10 Tonsillectomy; LUSC cis rs10266483 0.843 rs667644 chr7:63750558 C/A cg24201672 chr7:64023550 ZNF680 -0.43 -5.75 -0.3 1.98e-8 Response to statin therapy; LUSC cis rs7809950 0.817 rs2253833 chr7:107205669 A/G cg23024343 chr7:107201750 COG5 0.65 9.53 0.46 3.43e-19 Coronary artery disease; LUSC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.49 -8.1 -0.41 1.06e-14 Asthma; LUSC trans rs11098499 0.863 rs34308924 chr4:120481431 T/C cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg03146154 chr1:46216737 IPP -0.55 -8.02 -0.4 1.79e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11864453 0.826 rs6499559 chr16:72132064 G/C cg16558253 chr16:72132732 DHX38 -0.41 -6.32 -0.33 8.5e-10 Fibrinogen levels; LUSC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg27432699 chr2:27873401 GPN1 -0.53 -8.07 -0.4 1.32e-14 Total body bone mineral density; LUSC cis rs7568458 0.684 rs1048739 chr2:85764968 T/G cg17127132 chr2:85788382 GGCX 0.43 6.13 0.32 2.42e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2019216 0.500 rs12938673 chr17:21941987 C/G cg22648282 chr17:21454238 C17orf51 -0.5 -6.83 -0.35 4.12e-11 Pelvic organ prolapse; LUSC cis rs1775715 0.870 rs11008700 chr10:32236937 A/G cg04359828 chr10:32216031 ARHGAP12 0.38 6.47 0.33 3.5e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs500891 0.525 rs12215595 chr6:84055783 A/G cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.08e-14 Platelet-derived growth factor BB levels; LUSC trans rs2262909 0.849 rs10420483 chr19:22190378 A/G cg17074339 chr11:11642133 GALNTL4 -0.42 -6.27 -0.32 1.11e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7582720 1.000 rs72936842 chr2:203773686 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.38 0.42 1.49e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg04455712 chr21:45112962 RRP1B 0.46 8.61 0.43 2.95e-16 Mean corpuscular volume; LUSC cis rs11098499 0.863 rs9997631 chr4:120469995 C/G cg09307838 chr4:120376055 NA 0.76 11.3 0.53 2.7e-25 Corneal astigmatism; LUSC cis rs868036 0.681 rs4776981 chr15:68109474 G/A cg08079166 chr15:68083412 MAP2K5 0.41 7.29 0.37 2.33e-12 Restless legs syndrome; LUSC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg20120165 chr17:48586569 MYCBPAP -0.38 -6.2 -0.32 1.71e-9 Visceral fat; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19296258 chr17:78878799 RPTOR -0.39 -6.38 -0.33 6.01e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg16447950 chr5:562315 NA -0.58 -7.11 -0.36 7.26e-12 Obesity-related traits; LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg22963979 chr7:1858916 MAD1L1 -0.6 -9.44 -0.46 6.45e-19 Bipolar disorder and schizophrenia; LUSC cis rs12210905 0.610 rs72845208 chr6:27395664 C/A cg08851530 chr6:28072375 NA 0.93 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI; LUSC cis rs61931739 0.500 rs11053261 chr12:34530810 C/T cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs11997175 0.646 rs28785323 chr8:33736104 C/G ch.8.33884649F chr8:33765107 NA 0.53 8.04 0.4 1.6e-14 Body mass index; LUSC cis rs41271473 0.500 rs4440831 chr1:228887522 C/T cg16512390 chr1:228756714 NA -0.53 -7.67 -0.39 1.95e-13 Chronic lymphocytic leukemia; LUSC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg20135002 chr11:47629003 NA -0.52 -8.14 -0.41 8.1e-15 Subjective well-being; LUSC cis rs7107174 0.688 rs11237490 chr11:78135229 C/T cg27205649 chr11:78285834 NARS2 -0.53 -6.05 -0.31 3.93e-9 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.79 -0.35 5.13e-11 Lung cancer; LUSC cis rs7903847 0.656 rs74729163 chr10:99137287 A/C cg20016023 chr10:99160130 RRP12 -0.31 -6.58 -0.34 1.81e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg11871910 chr12:69753446 YEATS4 0.84 14.83 0.63 1.4e-38 Blood protein levels; LUSC cis rs6987853 0.563 rs2974302 chr8:42443119 C/G cg09913449 chr8:42400586 C8orf40 0.43 7.17 0.37 4.98e-12 Mean corpuscular hemoglobin concentration; LUSC cis rs2996428 0.601 rs10909804 chr1:3770929 A/G cg17443473 chr1:3703550 LRRC47 -0.33 -5.98 -0.31 5.78e-9 Red cell distribution width; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg24739457 chr1:205821442 NA 0.36 6.21 0.32 1.54e-9 Menarche (age at onset); LUSC cis rs7618501 0.966 rs13063621 chr3:49821625 T/C cg13072238 chr3:49761600 GMPPB 0.39 6.42 0.33 4.61e-10 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg15147215 chr3:52552868 STAB1 -0.32 -6.32 -0.33 8.13e-10 Bipolar disorder; LUSC cis rs11785400 0.642 rs4256574 chr8:143725705 C/T cg24634471 chr8:143751801 JRK 0.51 7.21 0.37 3.71e-12 Schizophrenia; LUSC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg17264618 chr3:40429014 ENTPD3 0.31 6.69 0.34 9.31e-11 Renal cell carcinoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10994148 chr6:99797842 C6orf168 -0.42 -6.51 -0.34 2.73e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg13319975 chr6:146136371 FBXO30 0.5 7.52 0.38 5.18e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9300255 0.596 rs4460848 chr12:123677810 A/G cg13010344 chr12:123464640 ARL6IP4 -0.48 -7.21 -0.37 3.65e-12 Neutrophil percentage of white cells; LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.78 0.3 1.69e-8 Menopause (age at onset); LUSC cis rs80130819 0.748 rs1074174 chr12:48696720 A/G cg24011408 chr12:48396354 COL2A1 0.44 5.68 0.3 2.86e-8 Prostate cancer; LUSC cis rs12681287 0.640 rs28561640 chr8:87425638 G/A cg27223183 chr8:87520930 FAM82B 0.55 7.52 0.38 4.95e-13 Caudate activity during reward; LUSC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg04111992 chr7:158790115 NA -0.39 -6.34 -0.33 7.35e-10 Facial morphology (factor 20); LUSC cis rs7683537 0.725 rs28837443 chr4:185641497 G/A cg04058563 chr4:185651563 MLF1IP 0.86 13.38 0.59 5.34e-33 Systemic lupus erythematosus; LUSC cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.64 9.92 0.48 1.63e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3125734 0.633 rs4979772 chr10:63967600 C/T cg19640130 chr10:64028056 RTKN2 0.41 7.3 0.37 2.19e-12 Rheumatoid arthritis; LUSC cis rs8062405 1.000 rs3888190 chr16:28889486 C/A cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.06e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4595586 0.505 rs11613808 chr12:39390823 T/A cg13010199 chr12:38710504 ALG10B 0.45 6.35 0.33 6.97e-10 Morning vs. evening chronotype; LUSC cis rs11190604 1.000 rs2495751 chr10:102327260 A/G cg23241863 chr10:102295624 HIF1AN 0.5 5.87 0.31 1.05e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7572733 0.534 rs1401095 chr2:198779867 C/T cg00792783 chr2:198669748 PLCL1 -0.45 -6.07 -0.32 3.49e-9 Dermatomyositis; LUSC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.39 8.24 0.41 4.07e-15 Hemoglobin concentration; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg17178900 chr1:205818956 PM20D1 0.8 13.77 0.6 1.84e-34 Menarche (age at onset); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg17392909 chr10:135187035 ECHS1 -0.47 -6.13 -0.32 2.54e-9 Cognitive function;Information processing speed; LUSC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg22437258 chr11:111473054 SIK2 0.51 7.07 0.36 9.11e-12 Primary sclerosing cholangitis; LUSC trans rs459571 0.959 rs465535 chr9:136910905 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.41 -5.96 -0.31 6.29e-9 Platelet distribution width; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04351903 chr1:202162209 LGR6 0.46 6.86 0.35 3.26e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4295623 0.553 rs34962960 chr8:11594597 G/A cg00262122 chr8:11665843 FDFT1 -0.44 -6.74 -0.35 6.85e-11 Morning vs. evening chronotype; LUSC cis rs9649465 0.522 rs662705 chr7:123431594 A/C cg03229431 chr7:123269106 ASB15 0.48 7.68 0.39 1.76e-13 Migraine; LUSC cis rs4845459 0.967 rs4845447 chr1:152590886 T/C cg08895932 chr1:152778580 LCE1C -0.36 -6.3 -0.33 9.62e-10 Psoriasis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26646903 chr3:186285208 TBCCD1 -0.44 -6.33 -0.33 7.96e-10 Hepatitis; LUSC cis rs34779708 0.750 rs35032841 chr10:35312687 G/A cg03585969 chr10:35415529 CREM 0.6 8.74 0.43 1.12e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7927592 0.913 rs11228262 chr11:68274907 G/T cg20283391 chr11:68216788 NA -0.61 -8.55 -0.42 4.43e-16 Total body bone mineral density; LUSC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg13010344 chr12:123464640 ARL6IP4 -0.51 -8.14 -0.41 8.17e-15 Platelet count; LUSC trans rs11098499 0.954 rs11098525 chr4:120390152 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.23 0.32 1.43e-9 Corneal astigmatism; LUSC cis rs74181299 0.855 rs2723066 chr2:65279321 T/G cg05010058 chr2:65284262 CEP68 0.31 6.11 0.32 2.75e-9 Pulse pressure; LUSC cis rs12597458 0.763 rs7195958 chr16:72036577 A/G cg01557791 chr16:72042693 DHODH 0.57 9.13 0.45 6.88e-18 Prostate cancer; LUSC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg21984481 chr17:79567631 NPLOC4 -0.72 -15.07 -0.64 1.65e-39 Eye color traits; LUSC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg25566285 chr7:158114605 PTPRN2 0.35 6.53 0.34 2.52e-10 Calcium levels; LUSC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg05347473 chr6:146136440 FBXO30 0.48 8.08 0.4 1.16e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs240764 0.658 rs11155673 chr6:101243283 A/T cg09795085 chr6:101329169 ASCC3 -0.46 -6.65 -0.34 1.18e-10 Neuroticism; LUSC cis rs7123876 0.587 rs11604034 chr11:72364147 G/C cg03713592 chr11:72463424 ARAP1 0.71 7.67 0.39 1.86e-13 Body mass index; LUSC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg06027949 chr8:82754900 SNX16 -0.43 -5.81 -0.3 1.48e-8 Diastolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10432423 chr10:51371707 LOC728407;PARG 0.46 6.01 0.31 4.96e-9 Bipolar disorder and schizophrenia; LUSC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg02079420 chr8:82753780 SNX16 -0.41 -7.03 -0.36 1.13e-11 Diastolic blood pressure; LUSC cis rs79149102 0.579 rs8033125 chr15:75374970 G/C cg09165964 chr15:75287851 SCAMP5 -0.73 -6.73 -0.35 7.21e-11 Lung cancer; LUSC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg15557168 chr22:42548783 NA 0.38 6.38 0.33 6.04e-10 Cognitive function; LUSC cis rs2154427 0.872 rs80098814 chr21:34133002 C/T cg21871883 chr21:34145043 C21orf49;C21orf66 0.65 5.74 0.3 2.14e-8 Bilirubin levels; LUSC cis rs6456156 0.792 rs10946214 chr6:167516122 G/A cg07741184 chr6:167504864 NA 0.37 6.48 0.33 3.33e-10 Primary biliary cholangitis; LUSC cis rs2046867 0.774 rs62249873 chr3:72907115 G/A cg25664220 chr3:72788482 NA -0.61 -9.76 -0.47 5.99e-20 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg21862992 chr11:68658383 NA 0.49 7.78 0.39 9.01e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2072499 0.898 rs2758609 chr1:156202868 G/A cg25208724 chr1:156163844 SLC25A44 1.02 20.47 0.75 6.66e-61 Testicular germ cell tumor; LUSC cis rs11098499 0.691 rs12510133 chr4:120271344 A/C cg09307838 chr4:120376055 NA 0.62 9.47 0.46 5.25e-19 Corneal astigmatism; LUSC cis rs2290159 0.752 rs3773352 chr3:12651982 G/C cg23032965 chr3:12705835 RAF1 0.74 8.95 0.44 2.58e-17 Cholesterol, total; LUSC cis rs4680 0.737 rs6269 chr22:19949952 A/G cg22546130 chr22:19950026 COMT -0.4 -8.65 -0.43 2.19e-16 Blood metabolite levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11557658 chr12:57914033 DDIT3 0.47 6.63 0.34 1.37e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1595825 1.000 rs1440091 chr2:198879457 C/T cg00982548 chr2:198649783 BOLL -0.48 -6.01 -0.31 4.72e-9 Ulcerative colitis; LUSC cis rs13089785 1.000 rs13089785 chr3:123653909 A/C cg19611163 chr3:123411211 MYLK 0.34 5.86 0.31 1.11e-8 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 12.72 0.57 1.67e-30 Platelet count; LUSC cis rs9420 0.961 rs11570190 chr11:57560452 A/C cg23127183 chr11:57508653 C11orf31 -0.56 -8.61 -0.43 2.83e-16 Schizophrenia; LUSC cis rs7829975 0.539 rs4841012 chr8:8551710 C/A cg06636001 chr8:8085503 FLJ10661 -0.46 -6.51 -0.34 2.78e-10 Mood instability; LUSC cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg25554036 chr4:6271136 WFS1 0.51 9.3 0.45 1.9e-18 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.87 -0.4 4.92e-14 Blood metabolite levels; LUSC cis rs865483 0.860 rs853220 chr17:35787666 C/T cg06716730 chr17:35851459 DUSP14 0.27 5.88 0.31 9.89e-9 Monocyte count; LUSC cis rs2486288 0.656 rs7167146 chr15:45571386 A/G cg26924012 chr15:45694286 SPATA5L1 0.73 10.57 0.5 9.9e-23 Glomerular filtration rate; LUSC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg01416388 chr22:39784598 NA -0.45 -7.6 -0.38 3.02e-13 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs6037121 chr20:25428311 G/A cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12291225 0.645 rs3763950 chr11:14278049 T/A cg05501817 chr11:14380813 RRAS2 -0.55 -8.68 -0.43 1.77e-16 Sense of smell; LUSC cis rs4655537 0.568 rs4655783 chr1:66143044 T/C cg04111102 chr1:66153794 NA 0.27 5.75 0.3 1.97e-8 Blood protein levels; LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg24642439 chr20:33292090 TP53INP2 0.55 8.27 0.41 3.33e-15 Height; LUSC cis rs3862030 0.720 rs7081467 chr10:104231662 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.86 -0.44 4.93e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs9393777 0.920 rs13195040 chr6:27413924 C/T cg06606381 chr12:133084897 FBRSL1 0.98 9.3 0.45 1.83e-18 Intelligence (multi-trait analysis); LUSC cis rs12928939 0.517 rs71384782 chr16:71978591 A/G cg03805757 chr16:71968109 PKD1L3 -0.63 -9.53 -0.46 3.42e-19 Post bronchodilator FEV1; LUSC cis rs9393777 0.545 rs56303243 chr6:26485727 G/A cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.45e-8 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg18681998 chr4:17616180 MED28 0.78 13.85 0.6 8.79e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11958404 0.932 rs6859470 chr5:157429505 T/G cg05962755 chr5:157440814 NA 0.54 6.35 0.33 7.18e-10 IgG glycosylation; LUSC cis rs9902453 0.834 rs9901694 chr17:28271645 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.55 0.5 1.18e-22 Coffee consumption (cups per day); LUSC trans rs634534 0.561 rs655744 chr11:65776585 G/T cg17712092 chr4:129076599 LARP1B -0.67 -10.38 -0.49 4.57e-22 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs6582630 0.622 rs11182004 chr12:38441254 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.75e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs2361718 0.527 rs11150847 chr17:78153130 G/A cg06718696 chr17:78121285 EIF4A3 0.45 6.33 0.33 7.8e-10 Yeast infection; LUSC cis rs11098499 0.644 rs10050092 chr4:120532085 T/C cg09307838 chr4:120376055 NA 0.6 9.13 0.45 6.85e-18 Corneal astigmatism; LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg02269571 chr22:50332266 NA -0.57 -8.54 -0.42 4.87e-16 Schizophrenia; LUSC cis rs1595825 0.891 rs73061068 chr2:198908439 A/G cg10547527 chr2:198650123 BOLL -0.53 -6.29 -0.33 9.68e-10 Ulcerative colitis; LUSC cis rs7592578 0.508 rs55919641 chr2:191265414 G/A cg11845111 chr2:191398756 TMEM194B -0.67 -9.01 -0.44 1.64e-17 Diastolic blood pressure; LUSC cis rs10986311 0.775 rs3758207 chr9:127132020 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.43 -7.08 -0.36 8.37e-12 Vitiligo; LUSC trans rs11696501 0.739 rs6073835 chr20:44286454 C/T cg03272292 chr12:48577362 C12orf68 0.48 6.0 0.31 5.2e-9 Brain structure; LUSC cis rs17125944 0.505 rs75296244 chr14:53233218 G/A cg13660082 chr14:53194042 PSMC6 -0.78 -6.81 -0.35 4.55e-11 Alzheimer's disease (late onset); LUSC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.74 0.3 2.17e-8 Self-reported allergy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19355881 chr6:34759549 UHRF1BP1 -0.5 -6.41 -0.33 4.94e-10 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg11764359 chr7:65958608 NA 0.55 7.28 0.37 2.46e-12 Aortic root size; LUSC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg17385448 chr1:15911702 AGMAT 0.36 6.18 0.32 1.92e-9 Systolic blood pressure; LUSC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg26587870 chr6:27730563 NA -0.65 -6.04 -0.31 4.2e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4666002 0.636 rs2272406 chr2:27892023 A/T cg27432699 chr2:27873401 GPN1 0.53 6.98 0.36 1.57e-11 Phospholipid levels (plasma); LUSC cis rs1865760 0.865 rs9467651 chr6:25958257 C/G cg16482183 chr6:26056742 HIST1H1C 0.46 6.87 0.35 3.17e-11 Height; LUSC cis rs6456156 0.811 rs975822 chr6:167516458 C/T cg07741184 chr6:167504864 NA -0.34 -5.88 -0.31 9.77e-9 Primary biliary cholangitis; LUSC cis rs9902453 0.934 rs7223645 chr17:28491029 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.19 0.41 5.67e-15 Coffee consumption (cups per day); LUSC cis rs77106637 0.860 rs1552224 chr11:72433098 A/C cg04827223 chr11:72435913 ARAP1 -0.77 -9.04 -0.44 1.31e-17 Type 2 diabetes; LUSC cis rs2404602 0.692 rs3110382 chr15:77148688 G/A cg23625390 chr15:77176239 SCAPER -0.45 -6.89 -0.35 2.75e-11 Blood metabolite levels; LUSC cis rs11025559 0.773 rs10833334 chr11:20498640 T/C cg19653624 chr11:20408972 PRMT3 -0.69 -8.45 -0.42 9.04e-16 Pursuit maintenance gain; LUSC cis rs12900413 1.000 rs12900413 chr15:90321039 C/T cg24249390 chr15:90295951 MESP1 0.42 6.34 0.33 7.42e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs677665 0.537 rs72641832 chr1:9336116 C/A cg25755851 chr1:9335794 NA 0.82 12.9 0.58 3.7e-31 Eosinophil percentage of white cells; LUSC cis rs72781680 0.716 rs2551325 chr2:23979729 C/T cg08917208 chr2:24149416 ATAD2B 0.6 6.68 0.34 1.01e-10 Lymphocyte counts; LUSC trans rs9329221 0.527 rs6989657 chr8:10330873 C/G cg15556689 chr8:8085844 FLJ10661 0.5 7.32 0.37 1.89e-12 Neuroticism; LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg22166914 chr1:53195759 ZYG11B -0.61 -10.19 -0.49 2.06e-21 Monocyte count; LUSC cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg06064525 chr11:970664 AP2A2 0.48 10.67 0.5 4.55e-23 Alzheimer's disease (late onset); LUSC cis rs10927875 1.000 rs4307563 chr1:16313788 C/T cg21385522 chr1:16154831 NA -0.79 -12.56 -0.57 6.57e-30 Dilated cardiomyopathy; LUSC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg25482853 chr8:67687455 SGK3 1.19 19.24 0.73 4.65e-56 Lung disease severity in cystic fibrosis; LUSC trans rs11700980 0.551 rs11701759 chr21:30115571 C/T cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs7216064 0.953 rs1599859 chr17:65837193 C/G cg12091567 chr17:66097778 LOC651250 -0.72 -9.17 -0.45 5.05e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs6598955 0.671 rs55791848 chr1:26582711 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg15744005 chr10:104629667 AS3MT -0.28 -5.9 -0.31 8.88e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7246967 0.673 rs937078 chr19:22811667 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs6940638 0.688 rs9348750 chr6:27057945 T/G cg12292205 chr6:26970375 C6orf41 -0.4 -5.94 -0.31 7.04e-9 Intelligence (multi-trait analysis); LUSC cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg06484146 chr7:12443880 VWDE -0.64 -6.3 -0.33 9.57e-10 Coronary artery disease; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.64 -0.39 2.24e-13 Electroencephalogram traits; LUSC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg26668713 chr11:65405903 SIPA1 0.56 6.6 0.34 1.57e-10 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs4132509 1.000 rs73124169 chr1:243804939 T/C cg21452805 chr1:244014465 NA 0.49 5.86 0.31 1.11e-8 RR interval (heart rate); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22128035 chr2:47168977 MCFD2;TTC7A 0.46 6.35 0.33 6.93e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs72674100 1.000 rs17026376 chr4:97993847 G/A cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg22875332 chr1:76189707 ACADM -0.78 -10.67 -0.5 4.69e-23 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2625529 0.775 rs4777466 chr15:72136872 C/T cg16672083 chr15:72433130 SENP8 -0.47 -7.77 -0.39 9.62e-14 Red blood cell count; LUSC trans rs60843830 1.000 rs3791220 chr2:227066 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.48 0.5 2.06e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs11031096 0.535 rs10767886 chr11:4218391 T/C cg18678763 chr11:4115507 RRM1 -0.41 -5.72 -0.3 2.37e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg12564285 chr5:131593104 PDLIM4 0.33 5.91 0.31 8.31e-9 Lung function (FEV1/FVC); LUSC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg11764359 chr7:65958608 NA 0.81 13.62 0.6 6.38e-34 Aortic root size; LUSC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.09 0.48 4.64e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs240764 0.621 rs11155636 chr6:101201243 C/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.46 -0.33 3.67e-10 Neuroticism; LUSC cis rs55665837 0.583 rs78843135 chr11:14411254 T/G cg05501817 chr11:14380813 RRAS2 -0.47 -7.41 -0.38 1.05e-12 Vitamin D levels; LUSC cis rs2072499 0.833 rs2251847 chr1:156204047 G/A cg25208724 chr1:156163844 SLC25A44 1.03 20.96 0.75 7.5e-63 Testicular germ cell tumor; LUSC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg09165964 chr15:75287851 SCAMP5 -1.07 -16.47 -0.67 4.95e-45 Blood trace element (Zn levels); LUSC cis rs3744061 0.557 rs9889862 chr17:74647976 A/G cg27546012 chr17:74684504 MXRA7 -0.37 -6.12 -0.32 2.56e-9 Retinal arteriolar caliber; LUSC cis rs67460515 0.563 rs6441362 chr3:160877613 G/A cg03342759 chr3:160939853 NMD3 -0.48 -6.62 -0.34 1.43e-10 Parkinson's disease; LUSC cis rs11190604 1.000 rs11190613 chr10:102313997 C/T cg07080220 chr10:102295463 HIF1AN -0.67 -9.09 -0.45 8.91e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs80130819 0.688 rs1552551 chr12:48643101 C/A cg24011408 chr12:48396354 COL2A1 0.46 5.84 0.3 1.22e-8 Prostate cancer; LUSC trans rs877282 0.945 rs11599043 chr10:777972 C/T cg22713356 chr15:30763199 NA 1.07 15.38 0.64 1.01e-40 Uric acid levels; LUSC cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg06552810 chr11:31128660 NA -0.42 -7.4 -0.38 1.09e-12 Red blood cell count; LUSC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg01973587 chr1:228161476 NA 0.47 8.49 0.42 6.91e-16 Diastolic blood pressure; LUSC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -6.9 -0.35 2.55e-11 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25808892 chr17:6459352 PITPNM3 -0.49 -6.19 -0.32 1.72e-9 Bipolar disorder and schizophrenia; LUSC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg02931644 chr1:25747376 RHCE 0.36 6.62 0.34 1.41e-10 Erythrocyte sedimentation rate; LUSC cis rs28830936 1.000 rs17677199 chr15:41954613 C/G cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.36 -0.33 6.8e-10 Diastolic blood pressure; LUSC cis rs6121246 0.609 rs4453755 chr20:30331047 G/A cg13852791 chr20:30311386 BCL2L1 0.93 14.15 0.61 6.1e-36 Mean corpuscular hemoglobin; LUSC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg03351412 chr1:154909251 PMVK 0.55 8.7 0.43 1.52e-16 Prostate cancer; LUSC cis rs7927771 0.542 rs11039336 chr11:47706141 A/G cg20307385 chr11:47447363 PSMC3 -0.43 -6.3 -0.33 9.19e-10 Subjective well-being; LUSC cis rs1832871 0.672 rs9457337 chr6:158726292 C/T cg07165851 chr6:158734300 TULP4 0.46 6.92 0.35 2.31e-11 Height; LUSC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg17968037 chr7:100024898 ZCWPW1 -0.42 -6.1 -0.32 2.9e-9 Platelet count; LUSC cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.22 0.49 1.61e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs714027 1.000 rs2412971 chr22:30494371 G/A cg11564601 chr22:30592435 NA -0.37 -6.95 -0.36 1.91e-11 Lymphocyte counts; LUSC cis rs11864453 0.612 rs12708925 chr16:72122706 A/T cg16558253 chr16:72132732 DHX38 -0.37 -5.83 -0.3 1.29e-8 Fibrinogen levels; LUSC cis rs9868809 0.505 rs11706203 chr3:48746239 T/A cg00383909 chr3:49044727 WDR6 1.14 10.58 0.5 9.77e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4356932 1.000 rs6819597 chr4:76957171 C/T cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs4776059 0.959 rs4548810 chr15:52943814 C/T cg22715398 chr15:52968154 KIAA1370 -0.59 -8.17 -0.41 6.55e-15 Schizophrenia; LUSC cis rs10911363 0.571 rs6424897 chr1:183419203 T/C cg09173681 chr1:183549694 NCF2 -0.64 -11.69 -0.54 1.06e-26 Systemic lupus erythematosus; LUSC cis rs7586879 0.521 rs1865689 chr2:25108197 C/T cg15423357 chr2:25149977 NA -0.4 -7.75 -0.39 1.12e-13 Body mass index; LUSC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg02269571 chr22:50332266 NA 0.59 8.74 0.43 1.17e-16 Schizophrenia; LUSC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg20399509 chr21:47717575 C21orf57 -0.42 -5.99 -0.31 5.55e-9 Testicular germ cell tumor; LUSC cis rs75920871 0.528 rs682048 chr11:116828320 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.13 -0.32 2.52e-9 Subjective well-being; LUSC cis rs36051895 0.632 rs7040922 chr9:5174829 A/G cg02405213 chr9:5042618 JAK2 0.6 9.07 0.44 1.06e-17 Pediatric autoimmune diseases; LUSC cis rs262150 0.851 rs2657326 chr7:158766262 C/T cg04111992 chr7:158790115 NA -0.37 -5.91 -0.31 8.33e-9 Facial morphology (factor 20); LUSC cis rs4660306 0.961 rs945179 chr1:45992460 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.41 6.5 0.33 3e-10 Homocysteine levels; LUSC cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs10782582 0.609 rs1689270 chr1:76390937 A/G cg10523679 chr1:76189770 ACADM -0.43 -6.18 -0.32 1.85e-9 Daytime sleep phenotypes; LUSC cis rs6500395 0.962 rs9937623 chr16:48571590 A/T cg04672837 chr16:48644449 N4BP1 -0.44 -6.32 -0.33 8.36e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg14061069 chr19:46274453 DMPK 0.68 14.07 0.61 1.26e-35 Coronary artery disease; LUSC cis rs11587682 0.760 rs12136802 chr1:150450204 T/C cg11822372 chr1:151115635 SEMA6C -0.43 -5.71 -0.3 2.48e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs61931739 0.500 rs7296061 chr12:34435009 A/G cg06521331 chr12:34319734 NA 0.4 6.35 0.33 7.1e-10 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg13047869 chr3:10149882 C3orf24 0.61 8.2 0.41 5.3e-15 Alzheimer's disease; LUSC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg11657440 chr19:46296263 DMWD 0.87 16.63 0.67 1.11e-45 Coronary artery disease; LUSC trans rs853679 0.517 rs35193936 chr6:28076270 A/G cg06606381 chr12:133084897 FBRSL1 -0.48 -6.26 -0.32 1.17e-9 Depression; LUSC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg03233332 chr7:66118400 NA -0.43 -6.24 -0.32 1.35e-9 Aortic root size; LUSC cis rs2219968 1.000 rs13255746 chr8:78954214 A/T cg00738934 chr8:78996279 NA 0.35 6.28 0.32 1.08e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs478304 0.654 rs11227260 chr11:65461158 G/T cg05805236 chr11:65401703 PCNXL3 -0.65 -10.56 -0.5 1.12e-22 Acne (severe); LUSC cis rs8063160 0.628 rs258322 chr16:89755903 C/T cg07984980 chr16:89898383 SPIRE2 0.57 6.23 0.32 1.38e-9 Red vs non-red hair color;Light vs. dark hair color;Brown vs. non-brown hair color; LUSC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg14298792 chr15:30685198 CHRFAM7A -0.51 -6.29 -0.33 9.95e-10 Huntington's disease progression; LUSC cis rs3768617 1.000 rs1360704 chr1:183099380 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.61 -8.83 -0.43 6.07e-17 Fuchs's corneal dystrophy; LUSC cis rs7246967 0.611 rs8108452 chr19:22853618 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.01 0.31 4.91e-9 Bronchopulmonary dysplasia; LUSC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg24399712 chr22:39784796 NA -0.65 -12.05 -0.55 5.03e-28 Intelligence (multi-trait analysis); LUSC cis rs7481584 0.961 rs729662 chr11:3028140 G/A cg08508325 chr11:3079039 CARS 0.3 5.65 0.3 3.45e-8 Calcium levels; LUSC cis rs5769707 0.642 rs4824070 chr22:50031521 T/C cg05373962 chr22:49881684 NA -0.42 -8.77 -0.43 9.43e-17 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg27170947 chr2:26402098 FAM59B -0.42 -5.75 -0.3 1.97e-8 Gut microbiome composition (summer); LUSC cis rs9300255 0.722 rs34997336 chr12:123829116 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 5.9 0.31 8.85e-9 Neutrophil percentage of white cells; LUSC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg12365402 chr11:9010492 NRIP3 0.44 8.26 0.41 3.41e-15 Hemoglobin concentration; LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg24675658 chr1:53192096 ZYG11B 0.59 9.22 0.45 3.51e-18 Monocyte count; LUSC cis rs7202877 0.706 rs247447 chr16:75486648 A/G cg03315344 chr16:75512273 CHST6 -0.49 -6.89 -0.35 2.86e-11 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6912958 0.558 rs9444530 chr6:88343318 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.25 0.32 1.25e-9 Monocyte percentage of white cells; LUSC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg01475377 chr6:109611718 NA -0.41 -7.38 -0.37 1.24e-12 Reticulocyte fraction of red cells; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.19e-26 Prudent dietary pattern; LUSC cis rs2444240 0.505 rs566935 chr11:120055477 C/G cg04390734 chr11:120039366 NA -0.31 -6.65 -0.34 1.19e-10 Corneal curvature; LUSC cis rs977987 0.778 rs4888409 chr16:75436231 A/T cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.8e-17 Dupuytren's disease; LUSC cis rs7089973 0.604 rs10490909 chr10:116593532 C/T cg03647239 chr10:116582469 FAM160B1 0.45 7.45 0.38 8.05e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4595586 0.545 rs1607042 chr12:39368028 A/G cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg05890377 chr2:74357713 NA 0.7 12.28 0.56 7.18e-29 Gestational age at birth (maternal effect); LUSC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg17366294 chr4:99064904 C4orf37 0.54 9.49 0.46 4.52e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs3772130 0.962 rs11715951 chr3:121522968 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.7 10.34 0.49 6.51e-22 Cognitive performance; LUSC cis rs9300255 0.602 rs1727314 chr12:123640664 C/A cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.15 -0.32 2.26e-9 Neutrophil percentage of white cells; LUSC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.23 0.32 1.44e-9 Multiple sclerosis; LUSC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg14541582 chr5:601475 NA -0.37 -5.71 -0.3 2.48e-8 Lung disease severity in cystic fibrosis; LUSC cis rs9534288 0.699 rs9534321 chr13:46669032 A/G cg15192986 chr13:46630673 CPB2 -0.72 -10.54 -0.5 1.29e-22 Blood protein levels; LUSC cis rs4711350 0.765 rs6921772 chr6:33749686 A/G cg18005901 chr6:33739558 LEMD2 -0.39 -5.75 -0.3 2.03e-8 Schizophrenia; LUSC cis rs7089973 0.525 rs11196945 chr10:116600424 G/A cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg17211192 chr8:82754475 SNX16 -0.58 -8.21 -0.41 5.01e-15 Diastolic blood pressure; LUSC cis rs6901250 0.788 rs571296 chr6:117092558 A/G cg12892004 chr6:117198278 RFX6 -0.43 -7.83 -0.39 6.65e-14 C-reactive protein levels; LUSC cis rs2295359 1.000 rs736197 chr1:67607135 G/T cg17031739 chr1:67600172 NA 0.39 6.02 0.31 4.67e-9 Psoriasis; LUSC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg26818010 chr10:134567672 INPP5A -0.86 -11.07 -0.52 1.83e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg23131131 chr22:24373011 LOC391322 0.48 6.97 0.36 1.65e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.42 6.57 0.34 1.92e-10 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.846 rs1660327 chr8:101292206 A/C cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.93e-13 Atrioventricular conduction; LUSC cis rs3806843 0.548 rs246038 chr5:140331699 A/G cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs4595586 0.545 rs2218761 chr12:39393593 A/G cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.24e-10 Height; LUSC cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg15556689 chr8:8085844 FLJ10661 0.56 8.52 0.42 5.66e-16 Mood instability; LUSC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg00546932 chr16:1947055 NA 0.36 5.75 0.3 2e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7267979 1.000 rs2257985 chr20:25269743 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.46 0.75 6.72e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.42 6.06 0.31 3.77e-9 Systemic lupus erythematosus; LUSC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg06634786 chr22:41940651 POLR3H 0.53 6.02 0.31 4.68e-9 Vitiligo; LUSC cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11644478 chr21:40555479 PSMG1 -0.59 -9.3 -0.45 1.88e-18 Menarche (age at onset); LUSC trans rs11098499 0.754 rs4443261 chr4:120249301 T/C cg25214090 chr10:38739885 LOC399744 0.44 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC trans rs10492201 0.529 rs11177004 chr12:68409009 G/A cg21566642 chr2:233284661 NA -0.38 -5.98 -0.31 5.86e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs1808579 0.870 rs11665096 chr18:21118025 G/C cg14672496 chr18:21087552 C18orf8 0.36 6.3 0.33 9.52e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs1003719 0.680 rs7276569 chr21:38578207 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC cis rs9790314 0.690 rs4679930 chr3:160842875 C/G cg03342759 chr3:160939853 NMD3 -0.42 -6.83 -0.35 3.91e-11 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg02415014 chr8:143852576 LYNX1 -0.33 -7.71 -0.39 1.44e-13 Urinary tract infection frequency; LUSC trans rs4927850 0.881 rs7630489 chr3:195753401 T/C cg21051086 chr3:73046214 PPP4R2 -0.52 -7.96 -0.4 2.63e-14 Pancreatic cancer; LUSC cis rs2573652 1.000 rs1469828 chr15:100517210 A/C cg09918751 chr15:100517450 ADAMTS17 -0.43 -8.06 -0.4 1.41e-14 Height; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg25703541 chr22:24373054 LOC391322 -0.87 -14.2 -0.61 3.93e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg22105103 chr4:187893119 NA 0.65 11.31 0.53 2.49e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg23992470 chr4:843637 GAK 0.53 5.66 0.3 3.33e-8 Intelligence (multi-trait analysis); LUSC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.41 -6.48 -0.33 3.26e-10 Bone mineral density (hip);Bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00037072 chr1:25573940 C1orf63 -0.41 -6.31 -0.33 8.87e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2243480 1.000 rs422164 chr7:65586605 C/G cg10756647 chr7:56101905 PSPH 0.83 8.29 0.41 2.8e-15 Diabetic kidney disease; LUSC cis rs13064411 0.696 rs7631082 chr3:113208913 C/G cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs11662586 1.000 rs11662586 chr18:77716171 A/C cg20368463 chr18:77673604 PQLC1 0.58 7.1 0.36 7.77e-12 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg24250549 chr1:154909240 PMVK 0.6 9.81 0.47 3.81e-20 Prostate cancer; LUSC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs6115168 chr20:25372891 C/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4237845 0.586 rs4760174 chr12:58320436 G/A cg02175503 chr12:58329896 NA 0.78 13.55 0.6 1.27e-33 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17783671 chr19:59070436 UBE2M;LOC100131691 -0.4 -6.03 -0.31 4.46e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs5756813 0.754 rs762982 chr22:38144235 A/G cg19894588 chr14:64061835 NA 0.54 7.25 0.37 2.93e-12 Optic cup area;Vertical cup-disc ratio; LUSC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg17279839 chr7:150038598 RARRES2 0.44 7.02 0.36 1.24e-11 Blood protein levels;Circulating chemerin levels; LUSC trans rs208520 0.690 rs12201219 chr6:66748862 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.83 0.68 1.93e-46 Exhaled nitric oxide output; LUSC cis rs3768617 0.510 rs6424884 chr1:183065904 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.71 0.51 3.22e-23 Fuchs's corneal dystrophy; LUSC cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.18 -0.37 4.64e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg13010199 chr12:38710504 ALG10B 0.68 10.49 0.5 1.99e-22 Bladder cancer; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg11149768 chr20:4129361 SMOX 0.55 6.53 0.34 2.44e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs672059 1.000 rs652753 chr1:183156569 A/T ch.1.3577855R chr1:183094577 LAMC1 0.54 7.99 0.4 2.15e-14 Hypertriglyceridemia; LUSC cis rs13418410 0.539 rs35866672 chr2:33842174 G/A cg04131969 chr2:33951647 MYADML -0.75 -10.99 -0.52 3.55e-24 Non-response to antidepressants and depression; LUSC cis rs8077889 0.956 rs4793026 chr17:41850508 A/G cg26893861 chr17:41843967 DUSP3 0.87 13.15 0.58 4.13e-32 Triglycerides; LUSC cis rs72781680 1.000 rs72796327 chr2:24140372 T/C cg20701182 chr2:24300061 SF3B14 0.74 7.48 0.38 6.68e-13 Lymphocyte counts; LUSC cis rs7264396 0.635 rs6058358 chr20:34492560 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.85 -0.44 5.17e-17 Total cholesterol levels; LUSC cis rs870825 0.929 rs72689263 chr4:185590961 C/T cg04058563 chr4:185651563 MLF1IP 0.83 11.29 0.53 2.87e-25 Blood protein levels; LUSC cis rs7241530 0.636 rs7242088 chr18:75903530 A/T cg14642773 chr18:75888474 NA 0.38 5.91 0.31 8.67e-9 Educational attainment (years of education); LUSC cis rs7927592 0.913 rs7109294 chr11:68332093 A/G cg16797656 chr11:68205561 LRP5 0.35 5.84 0.3 1.27e-8 Total body bone mineral density; LUSC cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs10896135 0.526 rs12795774 chr11:66381517 T/C cg24851651 chr11:66362959 CCS -0.52 -8.23 -0.41 4.24e-15 Bipolar disorder; LUSC cis rs5769707 0.749 rs8137251 chr22:50036669 G/A cg10356904 chr22:49881777 NA -0.3 -6.38 -0.33 6.04e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3760982 0.585 rs10422108 chr19:44294868 C/T cg11993925 chr19:44307056 LYPD5 0.35 7.59 0.38 3.12e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs4776059 0.798 rs10851520 chr15:52912978 C/G cg24008177 chr15:52972085 KIAA1370 -0.34 -6.21 -0.32 1.62e-9 Schizophrenia; LUSC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg03806693 chr22:41940476 POLR3H -0.99 -14.23 -0.61 3.07e-36 Vitiligo; LUSC cis rs11758351 1.000 rs76329209 chr6:26196430 A/G cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs1801251 1.000 rs4973054 chr2:233710713 G/C cg08000102 chr2:233561755 GIGYF2 -0.69 -11.36 -0.53 1.66e-25 Coronary artery disease; LUSC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg19748678 chr4:122722346 EXOSC9 0.5 7.67 0.39 1.86e-13 Type 2 diabetes; LUSC trans rs12050412 1.000 rs12050412 chr14:83378003 G/T cg08986871 chr7:100279334 GIGYF1 0.38 5.98 0.31 5.65e-9 Word reading; LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.87 -0.58 4.63e-31 Platelet count; LUSC trans rs7939886 0.764 rs79601668 chr11:55753767 G/C cg15704280 chr7:45808275 SEPT13 0.84 7.06 0.36 9.96e-12 Myopia (pathological); LUSC cis rs11645898 0.872 rs7206422 chr16:72152652 C/T cg14768367 chr16:72042858 DHODH -0.62 -6.67 -0.34 1.08e-10 Blood protein levels; LUSC cis rs977987 0.671 rs9922008 chr16:75335406 T/C cg03315344 chr16:75512273 CHST6 0.53 9.76 0.47 5.76e-20 Dupuytren's disease; LUSC cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg25427524 chr10:38739819 LOC399744 -0.63 -11.3 -0.53 2.67e-25 Extrinsic epigenetic age acceleration; LUSC cis rs4727027 0.704 rs12704070 chr7:148902789 G/A cg23583168 chr7:148888333 NA -0.89 -17.71 -0.7 5.65e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs8017423 0.967 rs7146640 chr14:90720114 C/T cg04374321 chr14:90722782 PSMC1 -0.67 -10.3 -0.49 9e-22 Mortality in heart failure; LUSC cis rs73206853 0.764 rs76044375 chr12:110901339 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.61 0.43 2.84e-16 Prudent dietary pattern; LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg22920501 chr2:26401640 FAM59B 0.79 9.74 0.47 6.82e-20 Gut microbiome composition (summer); LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.57 -9.0 -0.44 1.74e-17 Lymphocyte counts; LUSC trans rs13011075 0.878 rs17602092 chr2:68620410 T/A cg14221825 chr19:46271408 SIX5 0.44 6.24 0.32 1.35e-9 Mean corpuscular volume; LUSC cis rs3931020 0.508 rs2345436 chr1:75198740 A/C cg21535942 chr1:75199100 CRYZ;TYW3 0.43 5.96 0.31 6.27e-9 Resistin levels; LUSC cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.27 -0.41 3.16e-15 Schizophrenia; LUSC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg14668632 chr7:2872130 GNA12 -0.43 -6.13 -0.32 2.43e-9 Height; LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg25767906 chr1:53392781 SCP2 -0.62 -12.0 -0.55 7.69e-28 Monocyte count; LUSC cis rs1775715 0.674 rs2778670 chr10:32161676 G/A cg04359828 chr10:32216031 ARHGAP12 0.4 6.87 0.35 3.07e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg03433033 chr1:76189801 ACADM 0.72 9.41 0.46 8.07e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg23711669 chr6:146136114 FBXO30 0.8 14.56 0.62 1.59e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs3858526 0.834 rs10769395 chr11:5979620 G/A cg02574844 chr11:5959923 NA -0.46 -6.34 -0.33 7.59e-10 DNA methylation (variation); LUSC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg18765753 chr7:1198926 ZFAND2A -0.38 -7.02 -0.36 1.21e-11 Longevity;Endometriosis; LUSC cis rs10992471 0.535 rs10117041 chr9:95282331 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.9 -0.35 2.68e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg09491104 chr22:46646882 C22orf40 -0.72 -7.44 -0.38 8.4e-13 LDL cholesterol;Cholesterol, total; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18579396 chr17:41623924 ETV4 0.4 6.31 0.33 8.84e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7095944 0.614 rs12570348 chr10:126438963 A/C cg12521813 chr7:139477841 TBXAS1;HIPK2 -0.38 -5.94 -0.31 7.04e-9 Asthma; LUSC cis rs7267979 0.966 rs6083818 chr20:25346082 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1062753 0.771 rs932376 chr22:42614362 T/C cg00645731 chr22:42541494 CYP2D7P1 0.39 7.04 0.36 1.11e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs9399401 0.667 rs17071756 chr6:142715195 C/T cg03128060 chr6:142623767 GPR126 -0.54 -9.04 -0.44 1.34e-17 Chronic obstructive pulmonary disease; LUSC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg12751644 chr20:60527061 NA -0.36 -6.54 -0.34 2.26e-10 Body mass index; LUSC cis rs72772090 0.539 rs17405676 chr5:96182615 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.62 -6.99 -0.36 1.53e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg13206674 chr6:150067644 NUP43 0.59 9.14 0.45 6.26e-18 Lung cancer; LUSC cis rs2073300 0.609 rs6137917 chr20:23360369 G/A cg12062639 chr20:23401060 NAPB 0.92 8.03 0.4 1.65e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs8060686 0.641 rs118035472 chr16:68242311 A/G cg09835421 chr16:68378352 PRMT7 -0.52 -5.79 -0.3 1.59e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs1124376 0.935 rs28716666 chr3:20148409 C/T cg05072819 chr3:20081367 KAT2B 0.66 7.53 0.38 4.7e-13 Bipolar disorder and schizophrenia; LUSC cis rs9902453 0.791 rs57719820 chr17:28335088 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.56 -8.42 -0.42 1.12e-15 Coffee consumption (cups per day); LUSC cis rs12681287 0.547 rs9942793 chr8:87509091 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg04586622 chr2:25135609 ADCY3 -0.34 -7.06 -0.36 9.76e-12 Body mass index; LUSC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC trans rs72674100 1.000 rs7656873 chr4:97964668 A/G cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6469656 0.892 rs10088177 chr8:117756957 G/A cg24004040 chr8:117650383 NA -0.4 -5.97 -0.31 5.95e-9 Colorectal cancer; LUSC cis rs9325144 0.647 rs11169189 chr12:39097078 A/T cg13010199 chr12:38710504 ALG10B -0.46 -6.9 -0.35 2.7e-11 Morning vs. evening chronotype; LUSC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg13902645 chr11:5959945 NA -0.6 -8.44 -0.42 9.71e-16 DNA methylation (variation); LUSC cis rs2274459 0.841 rs10947432 chr6:33676556 A/G cg06253072 chr6:33679850 C6orf125 -0.49 -6.07 -0.32 3.49e-9 Obesity (extreme); LUSC cis rs2274273 0.774 rs9323278 chr14:55541574 C/G cg04306507 chr14:55594613 LGALS3 0.5 10.77 0.51 1.99e-23 Protein biomarker; LUSC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg12963246 chr6:28129442 ZNF389 0.52 7.17 0.37 4.94e-12 Depression; LUSC cis rs16854884 0.683 rs6766544 chr3:143736659 G/T cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Melanoma; LUSC cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg05340658 chr4:99064831 C4orf37 0.68 11.52 0.53 4.24e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg14895029 chr7:2775587 GNA12 0.36 5.91 0.31 8.63e-9 Height; LUSC cis rs6752107 1.000 rs13009506 chr2:234175706 A/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.72 -12.38 -0.56 3.15e-29 Crohn's disease;Inflammatory bowel disease; LUSC cis rs72781680 1.000 rs72781675 chr2:24232092 G/A cg08917208 chr2:24149416 ATAD2B 1.0 10.49 0.5 1.96e-22 Lymphocyte counts; LUSC cis rs7945718 0.967 rs2241857 chr11:12815831 C/T cg25843174 chr11:12811716 TEAD1 -0.33 -7.45 -0.38 8.15e-13 Educational attainment (years of education); LUSC cis rs62103177 0.565 rs473119 chr18:77849459 T/G cg20368463 chr18:77673604 PQLC1 -0.63 -6.71 -0.34 8.51e-11 Opioid sensitivity; LUSC cis rs3799379 0.530 rs10456045 chr6:26404958 A/G cg05738196 chr6:26577821 NA 0.44 5.77 0.3 1.84e-8 Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg18681998 chr4:17616180 MED28 0.85 15.49 0.65 3.6e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10744422 0.800 rs6489240 chr12:123275030 T/C cg25930673 chr12:123319894 HIP1R -0.6 -5.94 -0.31 7.08e-9 Schizophrenia; LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg16405210 chr4:1374714 KIAA1530 0.83 13.59 0.6 8.92e-34 Longevity; LUSC trans rs11088226 1.000 rs78679088 chr21:33910827 G/A cg09050820 chr6:167586206 TCP10L2 0.53 6.7 0.34 9.05e-11 Gastritis; LUSC cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg25801113 chr15:45476975 SHF 0.36 7.32 0.37 1.82e-12 Uric acid levels; LUSC cis rs7267979 1.000 rs422424 chr20:25445446 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg24201716 chr10:115933917 C10orf118;MIR2110 -0.37 -5.98 -0.31 5.65e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs17253792 1.000 rs28616134 chr14:56178802 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25201359 chr7:158622466 ESYT2 -0.42 -5.96 -0.31 6.53e-9 Electrocardiographic conduction measures; LUSC cis rs807669 0.525 rs9604934 chr22:19194868 C/T cg02655711 chr22:19163373 SLC25A1 0.48 8.62 0.43 2.82e-16 Metabolite levels; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg27535305 chr1:53392650 SCP2 -0.39 -7.19 -0.37 4.2e-12 Monocyte count; LUSC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg20887711 chr4:1340912 KIAA1530 0.55 8.58 0.43 3.61e-16 Longevity; LUSC cis rs4601821 0.522 rs754672 chr11:113249136 C/T cg14159747 chr11:113255604 NA 0.29 7.22 0.37 3.6e-12 Alcoholic chronic pancreatitis; LUSC cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg11584989 chr19:19387371 SF4 -0.53 -6.3 -0.33 9.26e-10 Bipolar disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03738959 chr9:37904295 MCART1 -0.45 -5.96 -0.31 6.3e-9 Hepatitis; LUSC trans rs17767294 0.708 rs113741085 chr6:27849982 C/A cg23539494 chr17:65276751 NA 0.74 6.11 0.32 2.7e-9 Parkinson's disease; LUSC cis rs7903847 0.642 rs2275090 chr10:99148151 A/G cg08345082 chr10:99160200 RRP12 -0.35 -7.17 -0.37 4.77e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs9807989 0.801 rs11123925 chr2:102977511 G/A cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg14895029 chr7:2775587 GNA12 -0.39 -5.87 -0.31 1.08e-8 Height; LUSC cis rs4555082 0.874 rs28625632 chr14:105748849 G/T cg10792982 chr14:105748885 BRF1 0.5 8.87 0.44 4.48e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -7.01 -0.36 1.33e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs644799 0.526 rs506180 chr11:95623109 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.61 8.93 0.44 2.99e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7582180 0.638 rs7581011 chr2:100954659 A/G cg08017756 chr2:100939284 LONRF2 0.43 7.96 0.4 2.7e-14 Intelligence (multi-trait analysis); LUSC cis rs708547 0.874 rs1718868 chr4:57881215 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 9.02 0.44 1.52e-17 Response to bleomycin (chromatid breaks); LUSC cis rs739401 0.611 rs401707 chr11:3050965 T/C cg25174290 chr11:3078921 CARS 0.59 9.43 0.46 6.87e-19 Longevity; LUSC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Melanoma; LUSC cis rs9300255 0.602 rs1716165 chr12:123648881 C/T cg05973401 chr12:123451056 ABCB9 0.54 6.67 0.34 1.06e-10 Neutrophil percentage of white cells; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20585088 chr3:182970927 MCF2L2;B3GNT5 0.42 6.52 0.34 2.59e-10 Triglycerides; LUSC cis rs9625935 0.748 rs1468177 chr22:30544559 C/T cg11564601 chr22:30592435 NA 0.35 6.23 0.32 1.38e-9 Tonsillectomy; LUSC cis rs9467773 0.933 rs35355150 chr6:26526039 G/A cg11502198 chr6:26597334 ABT1 0.56 8.73 0.43 1.21e-16 Intelligence (multi-trait analysis); LUSC cis rs6696846 0.729 rs72757512 chr1:205079203 G/A cg21545522 chr1:205238299 TMCC2 0.46 8.6 0.43 3.05e-16 Red blood cell count; LUSC cis rs17102423 0.731 rs1957949 chr14:65542607 C/T cg11161011 chr14:65562177 MAX -0.66 -10.19 -0.49 2.08e-21 Obesity-related traits; LUSC trans rs877282 0.898 rs12357016 chr10:765675 C/T cg22713356 chr15:30763199 NA 1.07 14.17 0.61 5.24e-36 Uric acid levels; LUSC cis rs459571 0.916 rs467303 chr9:136904835 C/T cg01294253 chr9:136912663 BRD3 0.34 5.77 0.3 1.8e-8 Platelet distribution width; LUSC trans rs4332037 0.539 rs4470910 chr7:2071723 C/T cg10840412 chr1:235813424 GNG4 0.54 7.09 0.36 8.24e-12 Bipolar disorder; LUSC cis rs2742417 0.603 rs7631818 chr3:45775931 A/T cg10512202 chr3:45649293 LIMD1 0.36 6.07 0.32 3.55e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.41 -0.33 4.97e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg27121462 chr16:89883253 FANCA 0.54 8.65 0.43 2.27e-16 Vitiligo; LUSC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs13089785 1.000 rs13088101 chr3:123625634 T/C cg02558132 chr3:123411198 MYLK 0.34 5.81 0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs41271473 1.000 rs72751929 chr1:228884358 A/G cg16512390 chr1:228756714 NA 0.49 5.91 0.31 8.31e-9 Chronic lymphocytic leukemia; LUSC cis rs1912483 0.505 rs11079772 chr17:45393739 A/C cg25173405 chr17:45401733 C17orf57 0.43 6.24 0.32 1.31e-9 Coronary artery disease; LUSC cis rs11098499 0.908 rs28559989 chr4:120386627 C/T cg09307838 chr4:120376055 NA 0.79 11.39 0.53 1.27e-25 Corneal astigmatism; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.39 -6.47 -0.33 3.47e-10 Prudent dietary pattern; LUSC cis rs1451375 0.617 rs9942686 chr7:50596381 G/A cg18232548 chr7:50535776 DDC 0.55 7.47 0.38 7.2e-13 Malaria; LUSC cis rs7786808 0.608 rs7784758 chr7:158214386 A/G cg09998033 chr7:158218633 PTPRN2 -0.43 -6.86 -0.35 3.32e-11 Obesity-related traits; LUSC cis rs7267979 1.000 rs4813562 chr20:25352588 G/A cg03522245 chr20:25566470 NINL -0.35 -5.68 -0.3 2.89e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9467773 0.620 rs1490488 chr6:26614808 T/C cg05738196 chr6:26577821 NA 0.79 15.3 0.64 1.98e-40 Intelligence (multi-trait analysis); LUSC cis rs56161922 1.000 rs57587123 chr1:207825415 A/G cg11752769 chr1:207818423 CR1L -0.71 -6.19 -0.32 1.75e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg18252515 chr7:66147081 NA -1.19 -14.26 -0.62 2.33e-36 Diabetic kidney disease; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg10150615 chr22:24372951 LOC391322 -0.38 -6.46 -0.33 3.75e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg18904891 chr8:8559673 CLDN23 0.38 5.97 0.31 6.05e-9 Mood instability; LUSC cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.65 0.65 8.39e-42 Bladder cancer; LUSC cis rs662064 0.748 rs2026792 chr1:10594790 A/G cg20482658 chr1:10539492 PEX14 0.32 6.4 0.33 5.2400000000000005e-10 Asthma; LUSC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.08e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs12908161 1.000 rs62021219 chr15:85256159 C/T cg17173187 chr15:85201210 NMB 0.51 9.69 0.47 9.71e-20 Schizophrenia; LUSC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg03676636 chr4:99064102 C4orf37 0.37 7.99 0.4 2.15e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2282802 0.685 rs6889283 chr5:139653439 G/T cg26211634 chr5:139558579 C5orf32 0.44 8.43 0.42 1.02e-15 Intelligence (multi-trait analysis); LUSC cis rs7804356 1.000 rs10276471 chr7:26837940 C/G cg03456212 chr7:26904342 SKAP2 -0.55 -6.47 -0.33 3.54e-10 Type 1 diabetes; LUSC cis rs1538970 0.962 rs7544178 chr1:45819069 C/T cg05343316 chr1:45956843 TESK2 0.61 8.59 0.43 3.38e-16 Platelet count; LUSC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs354225 0.544 rs13423873 chr2:54786677 A/G cg26097391 chr2:54893211 SPTBN1 0.48 7.09 0.36 8.21e-12 Schizophrenia; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.63 0.6 6.19e-34 Platelet count; LUSC cis rs11586313 0.597 rs1590931 chr1:152861866 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.68 -0.3 2.94e-8 Vitamin D levels; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02475777 chr4:1388615 CRIPAK 0.57 8.78 0.43 8.95e-17 Longevity; LUSC trans rs1376359 0.537 rs570890 chr1:103279575 T/A cg17154563 chr19:40477487 PSMC4 0.48 6.01 0.31 4.97e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg10664184 chr19:17420304 DDA1 0.46 6.0 0.31 5.19e-9 Systemic lupus erythematosus; LUSC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.42 0.5 3.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.62 0.47 1.68e-19 Bipolar disorder; LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 7.9e-43 Menopause (age at onset); LUSC cis rs2797160 1.000 rs2211418 chr6:125995503 G/A cg05901451 chr6:126070800 HEY2 -0.59 -8.88 -0.44 4.07e-17 Endometrial cancer; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg24642844 chr7:1081250 C7orf50 -0.8 -11.08 -0.52 1.72e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg13047869 chr3:10149882 C3orf24 0.6 8.27 0.41 3.15e-15 Alzheimer's disease; LUSC cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg22681709 chr2:178499509 PDE11A -0.52 -9.36 -0.46 1.21e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.71 0.51 3.28e-23 Bladder cancer; LUSC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg11752832 chr7:134001865 SLC35B4 0.56 8.77 0.43 9.14e-17 Mean platelet volume; LUSC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg10755058 chr3:40428713 ENTPD3 0.36 5.95 0.31 6.64e-9 Renal cell carcinoma; LUSC cis rs2760061 0.583 rs708110 chr1:228190805 T/A cg02753203 chr1:228287806 NA 0.97 18.8 0.72 2.7e-54 Diastolic blood pressure; LUSC cis rs459571 0.959 rs465535 chr9:136910905 C/T cg13789015 chr9:136890014 NCRNA00094 0.67 12.31 0.56 5.87e-29 Platelet distribution width; LUSC cis rs9513627 0.920 rs73556201 chr13:100128753 C/G cg25919922 chr13:100150906 NA -0.75 -6.44 -0.33 4.11e-10 Obesity-related traits; LUSC cis rs11997175 0.819 rs6415400 chr8:33783714 C/T ch.8.33884649F chr8:33765107 NA 0.54 8.92 0.44 3.03e-17 Body mass index; LUSC cis rs2274273 0.870 rs3783652 chr14:55854208 A/G cg04306507 chr14:55594613 LGALS3 0.53 11.78 0.54 4.98e-27 Protein biomarker; LUSC cis rs9768139 0.903 rs10262701 chr7:158114591 G/A cg06219351 chr7:158114137 PTPRN2 0.53 9.68 0.47 1.08e-19 Calcium levels; LUSC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg24209194 chr3:40518798 ZNF619 0.42 5.76 0.3 1.87e-8 Renal cell carcinoma; LUSC trans rs2235573 0.551 rs139895 chr22:38397034 A/G cg19894588 chr14:64061835 NA -0.44 -6.33 -0.33 7.68e-10 Glioblastoma;Glioma; LUSC cis rs10875746 0.951 rs2228500 chr12:48526712 A/G cg13454099 chr12:49076203 C12orf41 0.53 6.15 0.32 2.16e-9 Longevity (90 years and older); LUSC cis rs80130819 0.515 rs1793915 chr12:48386577 G/T cg24011408 chr12:48396354 COL2A1 0.49 6.07 0.32 3.52e-9 Prostate cancer; LUSC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg09359103 chr1:154839909 KCNN3 -0.7 -15.74 -0.65 3.87e-42 Prostate cancer; LUSC cis rs240764 0.746 rs151572 chr6:101110984 C/T cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs2235544 0.550 rs12075159 chr1:54470234 A/G cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.02e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg01416388 chr22:39784598 NA -0.38 -6.3 -0.33 9.27e-10 Intelligence (multi-trait analysis); LUSC cis rs12050794 0.671 rs8192362 chr15:72519858 G/A cg16672083 chr15:72433130 SENP8 0.47 7.85 0.39 5.73e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs963731 0.649 rs9679498 chr2:39218458 G/C cg04010122 chr2:39346883 SOS1 -0.82 -5.89 -0.31 9.62e-9 Corticobasal degeneration; LUSC cis rs11098499 0.644 rs28787668 chr4:120554687 G/A cg24375607 chr4:120327624 NA 0.72 11.34 0.53 1.99e-25 Corneal astigmatism; LUSC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg00484396 chr16:3507460 NAT15 0.55 7.97 0.4 2.56e-14 Body mass index (adult); LUSC cis rs4666002 0.956 rs3749147 chr2:27851918 G/A cg27432699 chr2:27873401 GPN1 0.42 5.8 0.3 1.51e-8 Phospholipid levels (plasma); LUSC cis rs12681288 0.676 rs935820 chr8:1022168 A/G cg04851639 chr8:1020857 NA -0.36 -7.8 -0.39 7.96e-14 Schizophrenia; LUSC cis rs701145 0.938 rs355747 chr3:153962973 T/C cg17054900 chr3:154042577 DHX36 0.85 9.0 0.44 1.75e-17 Coronary artery disease; LUSC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg23000734 chr10:126850823 CTBP2 -0.55 -8.97 -0.44 2.15e-17 Menarche (age at onset); LUSC cis rs12216125 0.537 rs12207059 chr6:25922385 C/T cg17691542 chr6:26056736 HIST1H1C 0.99 12.8 0.57 8.78e-31 Iron status biomarkers; LUSC cis rs10752881 1.000 rs4420053 chr1:182976133 A/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg15448220 chr1:150897856 SETDB1 -0.42 -6.19 -0.32 1.8e-9 Melanoma; LUSC cis rs8064299 0.655 rs734232 chr17:72765731 C/T cg25054828 chr17:72772726 NAT9;TMEM104 0.51 8.3 0.41 2.53e-15 Monocyte count; LUSC cis rs3106136 0.967 rs12645192 chr4:95181525 C/T cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.21 -0.32 1.59e-9 Capecitabine sensitivity; LUSC cis rs2439831 0.850 rs3097773 chr15:43893072 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.63 -6.48 -0.33 3.29e-10 Lung cancer in ever smokers; LUSC cis rs394563 0.967 rs447025 chr6:149799128 A/C cg11245181 chr6:149772854 ZC3H12D -0.3 -6.53 -0.34 2.46e-10 Dupuytren's disease; LUSC cis rs2224391 0.910 rs7752203 chr6:5260812 C/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.51 -7.36 -0.37 1.42e-12 Height; LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg21280719 chr6:42927975 GNMT -0.32 -7.86 -0.39 5.46e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg11871910 chr12:69753446 YEATS4 0.83 14.58 0.62 1.34e-37 Blood protein levels; LUSC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg13393036 chr8:95962371 TP53INP1 -0.46 -10.09 -0.48 4.61e-21 Type 2 diabetes; LUSC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg20203395 chr5:56204925 C5orf35 -0.45 -6.75 -0.35 6.67e-11 Coronary artery disease; LUSC cis rs6733011 0.628 rs6726156 chr2:99458607 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.43 -5.99 -0.31 5.4e-9 Bipolar disorder; LUSC cis rs9648716 0.515 rs38723 chr7:140695812 A/G cg23214464 chr7:140373596 ADCK2 0.74 6.33 0.33 8.04e-10 Type 2 diabetes; LUSC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11890956 chr21:40555474 PSMG1 1.05 21.14 0.76 1.45e-63 Cognitive function; LUSC cis rs11719291 0.915 rs11557629 chr3:48732223 G/A cg00383909 chr3:49044727 WDR6 1.04 9.56 0.46 2.68e-19 Cognitive function; LUSC cis rs6088590 0.965 rs6119534 chr20:33441257 C/T cg24642439 chr20:33292090 TP53INP2 0.7 10.68 0.5 4.13e-23 Coronary artery disease; LUSC cis rs6542838 0.580 rs1607256 chr2:99543444 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -5.84 -0.3 1.22e-8 Fear of minor pain; LUSC cis rs78579285 0.622 rs4782322 chr16:88797669 T/G cg01900006 chr16:88814613 FAM38A 0.61 6.84 0.35 3.88e-11 Joint mobility (Beighton score); LUSC cis rs908922 0.702 rs569232 chr1:152526643 A/G cg20991723 chr1:152506922 NA 0.48 8.51 0.42 6.06e-16 Hair morphology; LUSC cis rs7267979 0.833 rs4619688 chr20:25244101 C/G cg03522245 chr20:25566470 NINL 0.35 5.69 0.3 2.81e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7683537 0.887 rs7678412 chr4:185648611 T/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Systemic lupus erythematosus; LUSC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.34 6.62 0.34 1.47e-10 Schizophrenia; LUSC cis rs11608355 0.545 rs1073779 chr12:109894721 C/T cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.95 0.31 6.91e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.37 5.98 0.31 5.76e-9 Cystic fibrosis severity; LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg07507251 chr3:52567010 NT5DC2 0.33 6.37 0.33 6.25e-10 Bipolar disorder; LUSC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.54 0.34 2.24e-10 LDL cholesterol;Cholesterol, total; LUSC trans rs7746199 0.736 rs10484399 chr6:27534528 A/G cg01620082 chr3:125678407 NA -0.69 -6.89 -0.35 2.78e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1003719 0.788 rs2835588 chr21:38462716 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01726902 chr16:48419541 SIAH1 0.71 6.16 0.32 2.04e-9 Cognitive performance; LUSC cis rs4964805 0.549 rs2292682 chr12:104156520 C/T cg02344784 chr12:104178138 NT5DC3 0.39 6.11 0.32 2.71e-9 Attention deficit hyperactivity disorder; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg14004847 chr7:1930337 MAD1L1 -0.55 -8.35 -0.42 1.82e-15 Bipolar disorder and schizophrenia; LUSC cis rs77741769 0.571 rs4454799 chr12:121317075 A/C cg02419362 chr12:121203948 SPPL3 -0.46 -8.45 -0.42 9.34e-16 Mean corpuscular volume; LUSC trans rs11098499 0.874 rs13139045 chr4:120168588 T/C cg25214090 chr10:38739885 LOC399744 0.41 6.22 0.32 1.51e-9 Corneal astigmatism; LUSC cis rs17685 0.712 rs11770149 chr7:75791644 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.79 -0.39 8.8e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2228479 0.867 rs73276534 chr16:89950557 A/G cg04013166 chr16:89971882 TCF25 0.62 7.24 0.37 3.1e-12 Skin colour saturation; LUSC cis rs12519773 0.501 rs4321736 chr5:92533363 C/T cg18783429 chr5:92414398 NA 0.35 7.52 0.38 5.18e-13 Migraine; LUSC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg14829155 chr15:31115871 NA -0.56 -7.8 -0.39 8.07e-14 Huntington's disease progression; LUSC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.75 0.3 1.98e-8 Intelligence (multi-trait analysis); LUSC cis rs981844 0.712 rs4571310 chr4:154746832 T/C cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC trans rs79976124 0.837 rs10455591 chr6:66650584 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 9.0 0.44 1.77e-17 Type 2 diabetes; LUSC cis rs7582180 0.629 rs7597615 chr2:100954828 T/C cg14675211 chr2:100938903 LONRF2 0.37 5.73 0.3 2.29e-8 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg07362569 chr17:61921086 SMARCD2 -0.37 -7.24 -0.37 3.04e-12 Prudent dietary pattern; LUSC trans rs3749237 0.964 rs11717463 chr3:49808981 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.53 6.67 0.34 1.03e-10 Resting heart rate; LUSC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg25019033 chr10:957182 NA -0.52 -5.9 -0.31 9.08e-9 Eosinophil percentage of granulocytes; LUSC trans rs7647973 0.626 rs1463728 chr3:49647404 T/A cg21659725 chr3:3221576 CRBN -0.72 -8.2 -0.41 5.26e-15 Menarche (age at onset); LUSC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.95 -0.31 6.6e-9 Tonsillectomy; LUSC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg19774624 chr17:42201019 HDAC5 -0.81 -13.38 -0.59 5.26e-33 Total body bone mineral density; LUSC trans rs11098499 0.913 rs11098496 chr4:120167466 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC cis rs12681287 0.927 rs2953517 chr8:87332013 C/T cg27223183 chr8:87520930 FAM82B -0.46 -6.03 -0.31 4.39e-9 Caudate activity during reward; LUSC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg05340658 chr4:99064831 C4orf37 0.66 10.96 0.51 4.56e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs61823972 0.527 rs4951182 chr1:205236233 A/C cg21643547 chr1:205240462 TMCC2 0.3 5.66 0.3 3.24e-8 Immature fraction of reticulocytes;Mean corpuscular volume;Mean corpuscular hemoglobin;Mean corpuscular hemoglobin concentration;High light scatter reticulocyte count; LUSC cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg04990556 chr1:26633338 UBXN11 -0.46 -5.99 -0.31 5.52e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs4363385 0.818 rs11205176 chr1:153002481 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg24399712 chr22:39784796 NA -0.62 -10.99 -0.52 3.34e-24 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg27535305 chr1:53392650 SCP2 0.37 6.93 0.35 2.14e-11 Monocyte count; LUSC cis rs56399783 0.901 rs11764225 chr7:2775607 G/A cg14895029 chr7:2775587 GNA12 0.55 6.09 0.32 3.13e-9 Childhood ear infection; LUSC trans rs4596713 0.508 rs12056979 chr9:71778946 A/G cg25283916 chr1:242222868 NA -0.29 -6.0 -0.31 5.05e-9 Headache; LUSC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg11645453 chr3:52864694 ITIH4 0.34 8.08 0.4 1.23e-14 Electroencephalogram traits; LUSC cis rs6500395 1.000 rs12447645 chr16:48694440 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg05283184 chr6:79620031 NA -0.46 -8.73 -0.43 1.26e-16 Intelligence (multi-trait analysis); LUSC trans rs35110281 0.659 rs11702544 chr21:45091861 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.62 10.63 0.5 6.09e-23 Mean corpuscular volume; LUSC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg05738196 chr6:26577821 NA -0.48 -7.11 -0.36 6.88e-12 Autism spectrum disorder or schizophrenia; LUSC trans rs61931739 0.517 rs2636073 chr12:34063049 C/T cg13010199 chr12:38710504 ALG10B 0.54 8.3 0.41 2.53e-15 Morning vs. evening chronotype; LUSC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg25838465 chr1:92012736 NA -0.71 -14.32 -0.62 1.34e-36 Breast cancer; LUSC cis rs2879627 0.560 rs2186146 chr10:53679200 C/G cg06976598 chr10:53639124 PRKG1 0.46 5.85 0.31 1.15e-8 Coronary artery disease; LUSC cis rs2404602 0.716 rs4886817 chr15:76877702 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.96 -0.4 2.76e-14 Blood metabolite levels; LUSC cis rs7246967 0.673 rs3853653 chr19:22871932 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs791888 0.858 rs1555434 chr10:89419143 G/C cg13926569 chr10:89418898 PAPSS2 -0.37 -7.22 -0.37 3.56e-12 Magnesium levels; LUSC cis rs1832871 0.643 rs7750656 chr6:158725907 C/T cg07165851 chr6:158734300 TULP4 0.5 7.73 0.39 1.29e-13 Height; LUSC cis rs7707921 0.723 rs226197 chr5:81574925 G/A cg15871215 chr5:81402204 ATG10 0.46 7.03 0.36 1.14e-11 Breast cancer; LUSC trans rs1493916 1.000 rs1493916 chr18:31392577 T/G cg15819921 chr19:927150 ARID3A -0.44 -6.42 -0.33 4.77e-10 Life satisfaction; LUSC cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.93 0.51 5.81e-24 Bladder cancer; LUSC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 8.91 0.44 3.34e-17 Total body bone mineral density; LUSC cis rs6545883 0.894 rs4672436 chr2:61603357 A/C cg15711740 chr2:61764176 XPO1 0.41 6.27 0.32 1.12e-9 Tuberculosis; LUSC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC cis rs9650315 1.000 rs56261906 chr8:57158479 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.55 7.37 0.37 1.39e-12 Height; LUSC cis rs2742234 0.541 rs10793424 chr10:43717116 G/T cg15436174 chr10:43711423 RASGEF1A 0.44 7.06 0.36 9.75e-12 Hirschsprung disease; LUSC cis rs7223966 1.000 rs9891018 chr17:61827856 A/G cg00945038 chr17:61921165 SMARCD2 0.39 5.99 0.31 5.49e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9943753 0.525 rs983307 chr12:109815103 T/G cg19025524 chr12:109796872 NA -0.39 -7.12 -0.36 6.48e-12 HDL cholesterol; LUSC cis rs2191566 0.959 rs7256345 chr19:44510905 T/G cg03039196 chr19:44506973 ZNF230 0.36 5.93 0.31 7.69e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.5 -0.34 2.94e-10 Alzheimer's disease (late onset); LUSC cis rs765787 0.530 rs13329228 chr15:45533017 C/T cg24006582 chr15:45444508 DUOX1 -0.6 -8.69 -0.43 1.64e-16 Uric acid levels; LUSC cis rs2282300 0.910 rs528292 chr11:30389710 A/G cg25418670 chr11:30344373 C11orf46 0.51 7.16 0.36 5.23e-12 Morning vs. evening chronotype; LUSC cis rs2562456 0.917 rs2562466 chr19:21714204 C/T cg00806126 chr19:22604979 ZNF98 0.37 5.71 0.3 2.43e-8 Pain; LUSC cis rs1775715 0.707 rs2808094 chr10:32133756 T/C cg03015672 chr10:32216066 ARHGAP12 0.35 6.27 0.32 1.13e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1552244 0.507 rs6443274 chr3:9995288 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.6 -8.91 -0.44 3.37e-17 Alzheimer's disease; LUSC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg06074448 chr4:187884817 NA -0.39 -6.49 -0.33 3.06e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg12463550 chr7:65579703 CRCP -0.49 -7.14 -0.36 5.93e-12 Aortic root size; LUSC trans rs1005277 1.000 rs1005277 chr10:38218259 A/C cg17830980 chr10:43048298 ZNF37B 0.54 7.59 0.38 3.13e-13 Extrinsic epigenetic age acceleration; LUSC cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg24812749 chr6:127587940 RNF146 0.73 10.42 0.5 3.3e-22 Breast cancer; LUSC cis rs9788682 0.747 rs11072766 chr15:78771546 C/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.97 -0.31 6.23e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.1 -0.36 7.33e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.79 0.63 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9747201 0.963 rs11077982 chr17:80147377 G/C cg17462356 chr17:80056334 FASN -0.46 -6.21 -0.32 1.53e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2860975 1.000 rs7920659 chr10:96767924 T/C cg09036531 chr10:96991505 NA -0.4 -5.66 -0.3 3.24e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs7220711 0.967 rs1828720 chr17:41797692 A/C cg26893861 chr17:41843967 DUSP3 0.42 5.75 0.3 2.05e-8 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs6940638 0.956 rs72838268 chr6:27021173 A/G cg05738196 chr6:26577821 NA -0.5 -5.73 -0.3 2.25e-8 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18426487 chr10:35379348 CUL2 -0.47 -6.18 -0.32 1.92e-9 Bipolar disorder and schizophrenia; LUSC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg21963583 chr11:68658836 MRPL21 0.59 8.71 0.43 1.41e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9467773 0.620 rs2101582 chr6:26622734 C/T cg11502198 chr6:26597334 ABT1 0.69 11.61 0.54 2.11e-26 Intelligence (multi-trait analysis); LUSC cis rs983392 0.679 rs1026252 chr11:60030559 C/T cg02771260 chr11:59836817 MS4A3 0.37 5.99 0.31 5.34e-9 Alzheimer's disease (late onset); LUSC cis rs9581857 0.579 rs77187836 chr13:27998646 C/A cg22138327 chr13:27999177 GTF3A 0.83 9.36 0.46 1.23e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg10518543 chr12:38710700 ALG10B -0.41 -5.67 -0.3 3.11e-8 Morning vs. evening chronotype; LUSC cis rs3806843 1.000 rs10066278 chr5:140156318 A/C cg19875535 chr5:140030758 IK 0.47 7.7 0.39 1.54e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs9649213 0.727 rs12113294 chr7:97910637 C/G cg09267113 chr7:98030324 BAIAP2L1 0.52 8.02 0.4 1.83e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg23262351 chr6:79576851 IRAK1BP1 -0.37 -5.72 -0.3 2.41e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg27170947 chr2:26402098 FAM59B -0.65 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC cis rs11792861 0.781 rs11793272 chr9:111762102 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.55 7.91 0.4 3.87e-14 Menarche (age at onset); LUSC cis rs9653442 0.545 rs4851257 chr2:100775297 C/T cg22139774 chr2:100720529 AFF3 -0.41 -7.09 -0.36 8.27e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg00166722 chr3:10149974 C3orf24 0.54 7.43 0.38 8.88e-13 Alzheimer's disease; LUSC cis rs7605827 0.897 rs1996516 chr2:15517246 G/A cg19274914 chr2:15703543 NA 0.45 8.73 0.43 1.27e-16 Educational attainment (years of education); LUSC cis rs13385 0.723 rs28722951 chr5:139609952 T/G cg26211634 chr5:139558579 C5orf32 0.46 6.96 0.36 1.78e-11 Atrial fibrillation; LUSC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg03676636 chr4:99064102 C4orf37 0.36 7.91 0.4 3.77e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs6951245 0.507 rs11976805 chr7:1138716 C/T cg13565492 chr6:43139072 SRF -0.66 -9.67 -0.47 1.18e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs800082 0.839 rs17282884 chr3:144319905 C/T cg24215973 chr2:240111563 HDAC4 0.41 6.22 0.32 1.52e-9 Smoking behavior; LUSC cis rs1030268 0.640 rs12707092 chr7:133188145 C/G cg10665199 chr7:133106180 EXOC4 0.6 6.9 0.35 2.66e-11 Intelligence (multi-trait analysis); LUSC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11997175 0.574 rs4364597 chr8:33653729 G/C ch.8.33884649F chr8:33765107 NA 0.52 8.45 0.42 8.95e-16 Body mass index; LUSC cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg23711669 chr6:146136114 FBXO30 0.76 13.67 0.6 4.22e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs2731664 0.792 rs335452 chr5:176879671 C/T cg23176889 chr5:176863531 GRK6 -0.69 -14.36 -0.62 9.47e-37 Intelligence (multi-trait analysis); LUSC cis rs2455601 0.786 rs11042127 chr11:8947586 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.5 -8.07 -0.4 1.27e-14 Schizophrenia; LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg23758822 chr17:41437982 NA 1.06 19.99 0.74 4.88e-59 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05714094 chr11:117102988 RNF214;PCSK7 0.51 7.97 0.4 2.6e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg24434963 chr7:99006419 PDAP1;BUD31 0.75 5.95 0.31 6.85e-9 Cognitive performance; LUSC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg15595755 chr5:1867978 NA 0.47 8.64 0.43 2.38e-16 Cardiovascular disease risk factors; LUSC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg21361702 chr7:150065534 REPIN1 0.46 6.32 0.33 8.6e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg26587870 chr6:27730563 NA -0.61 -5.79 -0.3 1.62e-8 Breast cancer; LUSC cis rs72781680 0.898 rs72786279 chr2:24063266 C/T cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs4319547 0.656 rs2173582 chr12:122824694 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.42 -0.46 7.52e-19 Body mass index; LUSC trans rs1825630 1.000 rs1825630 chr3:59902801 C/T cg17670512 chr17:80627720 RAB40B -0.34 -6.09 -0.32 3.04e-9 Aortic root size; LUSC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg13798912 chr7:905769 UNC84A -0.58 -5.83 -0.3 1.29e-8 Cerebrospinal P-tau181p levels; LUSC cis rs782590 0.967 rs782592 chr2:55843875 T/A cg03859395 chr2:55845619 SMEK2 0.7 11.26 0.52 3.77e-25 Metabolic syndrome; LUSC cis rs7107174 1.000 rs10899478 chr11:78052238 C/T cg27205649 chr11:78285834 NARS2 -0.51 -5.82 -0.3 1.36e-8 Testicular germ cell tumor; LUSC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg24562669 chr7:97807699 LMTK2 0.34 5.95 0.31 6.83e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1448094 0.785 rs6539941 chr12:86452813 G/T cg02569458 chr12:86230093 RASSF9 -0.36 -5.72 -0.3 2.4e-8 Major depressive disorder; LUSC trans rs11098499 0.863 rs11731756 chr4:120478696 T/G cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg18252515 chr7:66147081 NA 1.24 14.01 0.61 2.1e-35 Diabetic kidney disease; LUSC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg07741184 chr6:167504864 NA -0.39 -6.9 -0.35 2.57e-11 Crohn's disease; LUSC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg09323728 chr8:95962352 TP53INP1 -0.33 -6.26 -0.32 1.19e-9 Type 2 diabetes; LUSC cis rs3857067 1.000 rs3857068 chr4:95026494 C/G cg11021082 chr4:95130006 SMARCAD1 0.32 6.02 0.31 4.54e-9 QT interval; LUSC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg04414720 chr1:150670196 GOLPH3L 0.54 8.42 0.42 1.09e-15 Melanoma; LUSC cis rs6840360 1.000 rs6839074 chr4:152603357 A/G cg22705602 chr4:152727874 NA 0.27 5.65 0.3 3.49e-8 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg08499158 chr17:42289980 UBTF -0.5 -8.21 -0.41 4.77e-15 Total body bone mineral density; LUSC cis rs9326248 0.581 rs6589582 chr11:116829200 A/C cg20608306 chr11:116969690 SIK3 0.37 6.8 0.35 4.7e-11 Blood protein levels; LUSC cis rs6977660 0.660 rs10239332 chr7:19824465 A/G cg07541023 chr7:19748670 TWISTNB 0.6 6.37 0.33 6.35e-10 Thyroid stimulating hormone; LUSC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11890956 chr21:40555474 PSMG1 1.03 19.78 0.73 3.52e-58 Cognitive function; LUSC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg13393036 chr8:95962371 TP53INP1 -0.31 -6.18 -0.32 1.91e-9 Type 2 diabetes; LUSC cis rs4478858 0.735 rs7526095 chr1:31797581 C/T cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC trans rs2786098 0.656 rs17622452 chr1:197560485 T/C cg16005942 chr6:160526640 IGF2R 0.5 6.04 0.31 4.16e-9 Asthma; LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg16325326 chr1:53192061 ZYG11B 0.69 11.17 0.52 7.98e-25 Monocyte count; LUSC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg00800038 chr16:89945340 TCF25 -0.75 -6.64 -0.34 1.26e-10 Skin colour saturation; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg10360139 chr7:1886902 MAD1L1 -0.4 -5.97 -0.31 6.04e-9 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg08859206 chr1:53392774 SCP2 -0.54 -9.35 -0.46 1.34e-18 Monocyte count; LUSC cis rs2204008 0.580 rs11174421 chr12:38105138 A/G cg13010199 chr12:38710504 ALG10B 0.57 8.14 0.41 8.11e-15 Bladder cancer; LUSC cis rs2219968 0.700 rs12541492 chr8:78863766 C/G cg00738934 chr8:78996279 NA -0.36 -6.1 -0.32 2.99e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs7829975 0.714 rs4841040 chr8:8654527 T/C cg27411982 chr8:10470053 RP1L1 0.41 6.24 0.32 1.31e-9 Mood instability; LUSC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg07701084 chr6:150067640 NUP43 0.57 8.79 0.43 7.84e-17 Lung cancer; LUSC cis rs734999 0.505 rs10910107 chr1:2539181 C/T cg18854424 chr1:2615690 NA 0.52 10.81 0.51 1.52e-23 Ulcerative colitis; LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 13.41 0.59 4.06e-33 Platelet count; LUSC trans rs7824557 0.527 rs2736296 chr8:11234844 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.76 -0.39 1.06e-13 Retinal vascular caliber; LUSC cis rs1712517 0.545 rs3740381 chr10:105046689 G/C cg04362960 chr10:104952993 NT5C2 -0.49 -6.66 -0.34 1.1e-10 Migraine; LUSC cis rs7264396 0.887 rs2236164 chr20:34097353 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.68 -0.34 9.98e-11 Total cholesterol levels; LUSC trans rs3774749 0.565 rs2518795 chr3:50208819 C/T cg21659725 chr3:3221576 CRBN 0.51 7.87 0.4 5.06e-14 Intelligence (multi-trait analysis); LUSC cis rs35146811 0.695 rs1618851 chr7:99810643 T/G cg22906224 chr7:99728672 NA -0.47 -6.52 -0.34 2.56e-10 Coronary artery disease; LUSC cis rs10089 1.000 rs10478796 chr5:127436187 A/G cg19767477 chr5:127420684 SLC12A2 -0.42 -5.8 -0.3 1.53e-8 Ileal carcinoids; LUSC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg06850241 chr22:41845214 NA -0.32 -6.01 -0.31 4.96e-9 Vitiligo; LUSC cis rs7202877 0.561 rs8050662 chr16:75360734 A/G cg03315344 chr16:75512273 CHST6 -0.41 -6.19 -0.32 1.74e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs611744 0.538 rs13257548 chr8:109273185 G/A cg18478394 chr8:109455254 TTC35 0.47 7.28 0.37 2.38e-12 Dupuytren's disease; LUSC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg03351412 chr1:154909251 PMVK 0.51 7.98 0.4 2.45e-14 Prostate cancer; LUSC cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg04586622 chr2:25135609 ADCY3 0.42 8.89 0.44 3.97e-17 Body mass index; LUSC cis rs6696846 0.749 rs11578293 chr1:205070178 T/C cg00857998 chr1:205179979 DSTYK 0.61 9.74 0.47 6.63e-20 Red blood cell count; LUSC cis rs2075165 0.870 rs12128955 chr1:156243821 C/T cg20302342 chr1:156215951 PAQR6 0.32 6.2 0.32 1.67e-9 Tonsillectomy; LUSC cis rs7267979 0.764 rs2474767 chr20:25246733 T/C cg08601574 chr20:25228251 PYGB 0.38 5.81 0.3 1.48e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9976767 0.637 rs9984108 chr21:43825628 T/G cg23042151 chr21:43824109 UBASH3A -0.35 -6.71 -0.34 8.39e-11 Type 1 diabetes; LUSC trans rs853679 0.882 rs9393908 chr6:28190830 T/A cg01620082 chr3:125678407 NA -0.59 -6.38 -0.33 5.96e-10 Depression; LUSC trans rs3749237 0.964 rs1799843 chr3:49849723 G/A cg21659725 chr3:3221576 CRBN 0.6 8.77 0.43 9.54e-17 Resting heart rate; LUSC cis rs7180079 1.000 rs62021590 chr15:64521349 A/T cg08069370 chr15:64387884 SNX1 -0.54 -5.85 -0.3 1.17e-8 Monocyte count; LUSC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg03289416 chr15:75166202 SCAMP2 0.44 6.85 0.35 3.58e-11 Breast cancer; LUSC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.83 -15.06 -0.64 1.77e-39 Total body bone mineral density; LUSC cis rs4930561 0.714 rs7950451 chr11:67962406 C/A cg16338278 chr11:67432957 ALDH3B2 0.4 6.73 0.35 7.35e-11 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs11608355 0.515 rs35691047 chr12:109932585 C/T cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs897984 0.806 rs1046276 chr16:30914626 A/G cg02466173 chr16:30829666 NA 0.55 11.16 0.52 8.55e-25 Dementia with Lewy bodies; LUSC cis rs9868809 0.505 rs35064573 chr3:48740280 C/A cg00383909 chr3:49044727 WDR6 1.14 10.58 0.5 9.36e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC trans rs7737355 0.947 rs10478980 chr5:130618247 C/T cg07715041 chr7:99302981 CYP3A7 -0.39 -6.14 -0.32 2.3e-9 Life satisfaction; LUSC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg22433210 chr17:43662623 NA 0.75 10.94 0.51 5.08e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs4820294 0.669 rs35662099 chr22:38053909 C/T cg21798802 chr22:38057573 PDXP 0.33 6.71 0.34 8.49e-11 Fat distribution (HIV); LUSC cis rs6487679 0.526 rs7972426 chr12:9381254 C/T cg08997352 chr12:9597637 DDX12 -0.4 -5.66 -0.3 3.21e-8 Non-alcoholic fatty liver disease histology (AST); LUSC cis rs7512552 0.966 rs2147324 chr1:150255587 T/C cg15654264 chr1:150340011 RPRD2 -0.6 -9.68 -0.47 1.11e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg25039879 chr17:56429692 SUPT4H1 0.39 5.83 0.3 1.3e-8 Cognitive test performance; LUSC trans rs116988415 0.584 rs17180497 chr14:65269707 A/C cg25021359 chr7:123315035 NA -0.42 -6.13 -0.32 2.53e-9 Daytime sleep phenotypes; LUSC cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.05 0.55 5.22e-28 Motion sickness; LUSC trans rs4332037 0.826 rs4721188 chr7:1953615 G/A cg10840412 chr1:235813424 GNG4 -0.6 -8.34 -0.42 1.92e-15 Bipolar disorder; LUSC cis rs13256369 0.802 rs12541520 chr8:8564146 G/T cg06671706 chr8:8559999 CLDN23 0.43 5.93 0.31 7.58e-9 Obesity-related traits; LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.88 0.66 1.08e-42 Platelet count; LUSC cis rs672059 1.000 rs479994 chr1:183161729 C/T ch.1.3577855R chr1:183094577 LAMC1 0.55 8.06 0.4 1.37e-14 Hypertriglyceridemia; LUSC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg21984481 chr17:79567631 NPLOC4 -0.59 -11.38 -0.53 1.45e-25 Eye color traits; LUSC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.28 0.59 1.28e-32 Total body bone mineral density; LUSC cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg17845761 chr1:175162550 KIAA0040 0.31 5.93 0.31 7.53e-9 Alcohol dependence; LUSC cis rs9393777 0.623 rs9366658 chr6:26469866 G/A cg05738196 chr6:26577821 NA -0.54 -5.81 -0.3 1.48e-8 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg00409905 chr10:38381863 ZNF37A -0.34 -6.04 -0.31 4.06e-9 Extrinsic epigenetic age acceleration; LUSC trans rs61931739 0.635 rs10743837 chr12:33982162 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.6 0.38 3.09e-13 Morning vs. evening chronotype; LUSC cis rs983392 0.792 rs1303615 chr11:59885120 C/T cg20284999 chr11:59952153 MS4A6A -0.33 -5.84 -0.3 1.21e-8 Alzheimer's disease (late onset); LUSC cis rs240764 0.817 rs240164 chr6:101044487 T/A cg09795085 chr6:101329169 ASCC3 0.4 5.74 0.3 2.17e-8 Neuroticism; LUSC cis rs3820068 0.608 rs10927840 chr1:16045250 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.96 0.31 6.28e-9 Systolic blood pressure; LUSC trans rs4942242 0.640 rs9533563 chr13:44212127 A/G cg19169023 chr15:41853346 TYRO3 -0.59 -8.71 -0.43 1.38e-16 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs782590 0.967 rs11125581 chr2:55796527 C/G cg03859395 chr2:55845619 SMEK2 0.86 16.16 0.66 8.48e-44 Metabolic syndrome; LUSC cis rs7586879 0.789 rs11688754 chr2:25133885 C/T cg01884057 chr2:25150051 NA 0.42 8.42 0.42 1.11e-15 Body mass index; LUSC cis rs67696533 0.711 rs4911241 chr20:31140165 C/T cg13636640 chr20:31349939 DNMT3B 0.46 6.24 0.32 1.33e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9800506 0.584 rs6936583 chr6:35525925 G/A cg03566752 chr6:35512600 NA 0.35 7.72 0.39 1.34e-13 Neutrophil percentage of granulocytes; LUSC cis rs317689 0.513 rs529268 chr12:69687051 G/A cg14784868 chr12:69753453 YEATS4 0.54 8.06 0.4 1.39e-14 Response to diuretic therapy; LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9291683 0.530 rs17246501 chr4:9985710 A/C cg26043149 chr18:55253948 FECH 0.45 6.98 0.36 1.61e-11 Bone mineral density; LUSC cis rs2295359 1.000 rs4655683 chr1:67611613 C/T cg03340356 chr1:67600835 NA 0.4 6.68 0.34 9.97e-11 Psoriasis; LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg16405210 chr4:1374714 KIAA1530 -0.54 -8.62 -0.43 2.69e-16 Obesity-related traits; LUSC cis rs9467773 0.620 rs9461275 chr6:26590801 C/T cg09904177 chr6:26538194 HMGN4 0.69 12.34 0.56 4.53e-29 Intelligence (multi-trait analysis); LUSC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg09034736 chr1:150693464 HORMAD1 0.48 6.97 0.36 1.72e-11 Tonsillectomy; LUSC cis rs4808199 0.948 rs757001 chr19:19448808 G/A cg03709012 chr19:19516395 GATAD2A 0.99 12.02 0.55 6.89e-28 Nonalcoholic fatty liver disease; LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg18099408 chr3:52552593 STAB1 -0.4 -6.87 -0.35 3.17e-11 Bipolar disorder; LUSC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg27286337 chr10:134555280 INPP5A 0.91 11.32 0.53 2.31e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2798269 0.966 rs2798268 chr13:22131690 A/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.13 -0.32 2.42e-9 PR segment; LUSC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg15744005 chr10:104629667 AS3MT -0.28 -5.92 -0.31 8.11e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4665630 0.522 rs2551351 chr2:23914065 C/T cg08063864 chr2:24346004 PFN4;LOC375190 -0.8 -7.21 -0.37 3.88e-12 Hypertension; LUSC trans rs1325195 0.920 rs2816183 chr1:179116474 C/G cg11624085 chr17:8464688 MYH10 0.43 7.08 0.36 8.7e-12 IgE grass sensitization; LUSC cis rs1595825 0.838 rs73058883 chr2:198896255 C/T cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs929354 0.742 rs3808317 chr7:156944460 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg02475777 chr4:1388615 CRIPAK 0.43 6.42 0.33 4.81e-10 Obesity-related traits; LUSC cis rs561341 0.739 rs9906455 chr17:30215669 G/A cg13647721 chr17:30228624 UTP6 -0.68 -7.84 -0.39 5.94e-14 Hip circumference adjusted for BMI; LUSC cis rs11758351 0.734 rs56220351 chr6:26206884 A/G cg01420254 chr6:26195488 NA 0.67 7.49 0.38 6.09e-13 Gout;Renal underexcretion gout; LUSC cis rs11051970 1.000 rs1872829 chr12:32535100 C/T cg02745156 chr12:32552066 NA 0.46 7.51 0.38 5.47e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7267979 1.000 rs11087521 chr20:25440648 G/A cg03522245 chr20:25566470 NINL 0.35 5.7 0.3 2.66e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3125734 0.608 rs7094950 chr10:64019744 T/C cg09941381 chr10:64027924 RTKN2 -0.38 -7.05 -0.36 1.03e-11 Rheumatoid arthritis; LUSC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg12311346 chr5:56204834 C5orf35 0.83 13.75 0.6 2.09e-34 Initial pursuit acceleration; LUSC cis rs11098499 0.909 rs79026312 chr4:120440677 C/A cg24375607 chr4:120327624 NA 0.76 11.01 0.52 2.89e-24 Corneal astigmatism; LUSC cis rs2742417 1.000 rs2742389 chr3:45756683 G/C cg09608765 chr3:45636137 LIMD1 -0.39 -7.81 -0.39 7.4e-14 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2235544 0.554 rs7540270 chr1:54484682 A/G cg25741118 chr1:54482237 LDLRAD1 -0.33 -7.61 -0.38 2.85e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs2281558 0.833 rs55792313 chr20:25521255 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.61 9.2 0.45 4.07e-18 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg03188948 chr7:1209495 NA 0.61 6.38 0.33 5.97e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg07701084 chr6:150067640 NUP43 0.53 8.04 0.4 1.54e-14 Lung cancer; LUSC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs763121 0.744 rs5757140 chr22:38957013 T/C cg14440974 chr22:39074834 NA -0.38 -6.31 -0.33 8.64e-10 Menopause (age at onset); LUSC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg04267008 chr7:1944627 MAD1L1 -0.57 -8.51 -0.42 6.15e-16 Bipolar disorder and schizophrenia; LUSC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg01017244 chr2:74357527 NA 0.67 11.25 0.52 4.08e-25 Gestational age at birth (maternal effect); LUSC cis rs17639215 0.550 rs9679297 chr2:102914569 T/C cg09003973 chr2:102972529 NA 0.57 7.23 0.37 3.39e-12 Serum protein levels (sST2); LUSC cis rs921968 0.643 rs832801 chr2:219488698 G/A cg02176678 chr2:219576539 TTLL4 0.58 10.63 0.5 6.37e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs11098499 0.754 rs17595608 chr4:120250506 C/T cg24375607 chr4:120327624 NA 0.76 12.09 0.55 3.61e-28 Corneal astigmatism; LUSC cis rs9467773 0.620 rs9295701 chr6:26627508 T/C cg05738196 chr6:26577821 NA 0.79 15.0 0.63 2.98e-39 Intelligence (multi-trait analysis); LUSC cis rs637571 0.544 rs55704213 chr11:65730002 C/A cg26695010 chr11:65641043 EFEMP2 -0.48 -6.96 -0.36 1.85e-11 Eosinophil percentage of white cells; LUSC cis rs7568458 0.846 rs7605975 chr2:85772548 C/T cg17127132 chr2:85788382 GGCX 0.45 7.07 0.36 9.2e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9549367 0.713 rs9549356 chr13:113851633 A/G cg00898013 chr13:113819073 PROZ -0.63 -8.82 -0.43 6.52e-17 Platelet distribution width; LUSC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg02221750 chr19:17393354 ANKLE1 -0.92 -14.02 -0.61 2.02e-35 Systemic lupus erythematosus; LUSC cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg18225595 chr11:63971243 STIP1 0.47 5.77 0.3 1.82e-8 Mean platelet volume; LUSC cis rs2230307 0.505 rs482873 chr1:100589757 C/T cg24955406 chr1:100503596 HIAT1 -0.63 -6.65 -0.34 1.19e-10 Carotid intima media thickness; LUSC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg26879891 chr1:152191343 HRNR -0.38 -6.79 -0.35 5.24e-11 Inflammatory skin disease; LUSC cis rs1322639 1.000 rs1322639 chr6:169587103 G/A cg04662567 chr6:169592167 NA 0.43 6.44 0.33 4.28e-10 Pulse pressure; LUSC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC trans rs9944715 0.911 rs9956574 chr18:43782203 C/T cg01718231 chr17:29326311 RNF135 -0.55 -7.88 -0.4 4.55e-14 Red cell distribution width;Mean corpuscular volume; LUSC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg17264618 chr3:40429014 ENTPD3 0.29 6.07 0.32 3.46e-9 Renal cell carcinoma; LUSC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC trans rs6951245 1.000 rs113066613 chr7:1094128 T/C cg13565492 chr6:43139072 SRF -0.61 -6.37 -0.33 6.1e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs35110281 0.807 rs2838328 chr21:45023234 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.94 0.48 1.48e-20 Mean corpuscular volume; LUSC cis rs5758511 0.573 rs2267438 chr22:42237565 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.4 -7.53 -0.38 4.88e-13 Birth weight; LUSC cis rs11711311 1.000 rs2242108 chr3:113433903 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.17 0.37 4.82e-12 IgG glycosylation; LUSC cis rs2404602 0.647 rs12904417 chr15:76964152 A/G cg23625390 chr15:77176239 SCAPER 0.65 10.01 0.48 8.38e-21 Blood metabolite levels; LUSC cis rs4951018 0.821 rs7529037 chr1:205637501 C/G cg11965913 chr1:205819406 PM20D1 -0.41 -6.22 -0.32 1.45e-9 Prostate-specific antigen levels; LUSC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg11752832 chr7:134001865 SLC35B4 0.52 7.99 0.4 2.24e-14 Mean platelet volume; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg19318889 chr4:1322082 MAEA 0.47 7.87 0.4 4.96e-14 Longevity; LUSC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg26924012 chr15:45694286 SPATA5L1 -1.1 -20.24 -0.74 5.13e-60 Homoarginine levels; LUSC cis rs7527798 1.000 rs35728110 chr1:207821397 T/C cg09232269 chr1:207846808 CR1L -0.32 -5.67 -0.3 3.05e-8 Erythrocyte sedimentation rate; LUSC cis rs11997175 0.583 rs17780153 chr8:33789161 A/G ch.8.33884649F chr8:33765107 NA 0.46 6.76 0.35 6.32e-11 Body mass index; LUSC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg19077165 chr18:44547161 KATNAL2 0.41 6.18 0.32 1.84e-9 Personality dimensions; LUSC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg04450456 chr4:17643702 FAM184B 0.39 6.46 0.33 3.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9486719 0.895 rs34051754 chr6:97007754 A/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.98 -0.48 1.09e-20 Migraine;Coronary artery disease; LUSC cis rs1595825 0.891 rs16825786 chr2:198794681 G/T cg10547527 chr2:198650123 BOLL -0.5 -6.04 -0.31 4.1e-9 Ulcerative colitis; LUSC cis rs4073582 0.595 rs528842 chr11:66032390 G/A cg16950941 chr11:66035639 RAB1B 0.54 8.01 0.4 1.96e-14 Gout; LUSC trans rs911555 0.755 rs55742283 chr14:103942965 A/G cg17675199 chr6:35436792 RPL10A -0.42 -6.12 -0.32 2.57e-9 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06513149 chr13:33002431 N4BP2L1 0.43 6.4 0.33 5.14e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10761482 0.861 rs10994310 chr10:62106169 C/T cg18175470 chr10:62150864 ANK3 0.48 6.91 0.35 2.44e-11 Schizophrenia; LUSC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg16006841 chr5:176797999 RGS14 0.65 10.5 0.5 1.79e-22 Hemoglobin concentration;Hematocrit; LUSC cis rs9646944 0.501 rs12991737 chr2:103018128 T/A cg20060108 chr2:102954350 IL1RL1 0.48 6.6 0.34 1.65e-10 Blood protein levels; LUSC cis rs5758659 1.000 rs134873 chr22:42657566 T/G cg04733989 chr22:42467013 NAGA 0.4 6.34 0.33 7.46e-10 Cognitive function; LUSC cis rs11191205 0.954 rs11191191 chr10:103800979 G/A cg15320455 chr10:103880129 LDB1 0.53 5.9 0.31 8.98e-9 Intelligence (multi-trait analysis); LUSC cis rs12541635 0.899 rs1429676 chr8:107065790 G/A cg10147462 chr8:107024639 NA -0.54 -9.76 -0.47 6e-20 Age of smoking initiation; LUSC cis rs1048238 0.525 rs848214 chr1:16265422 A/G cg21385522 chr1:16154831 NA -0.54 -8.52 -0.42 5.4e-16 Systolic blood pressure; LUSC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg22963979 chr7:1858916 MAD1L1 0.53 8.21 0.41 4.93e-15 Bipolar disorder and schizophrenia; LUSC cis rs10504073 0.647 rs10504072 chr8:49993083 G/A cg00325661 chr8:49890786 NA 0.62 9.93 0.48 1.51e-20 Blood metabolite ratios; LUSC trans rs1814175 0.586 rs10769603 chr11:49688837 T/C cg03929089 chr4:120376271 NA -0.91 -14.96 -0.63 4.43e-39 Height; LUSC cis rs1865760 0.865 rs9393677 chr6:25945815 G/A cg12310025 chr6:25882481 NA -0.34 -5.74 -0.3 2.11e-8 Height; LUSC cis rs12802244 1 rs12802244 chr11:47932666 G/A cg20135002 chr11:47629003 NA -0.45 -6.9 -0.35 2.56e-11 Neuroticism; LUSC cis rs2486288 0.656 rs10519018 chr15:45549265 C/T cg26924012 chr15:45694286 SPATA5L1 -0.71 -10.37 -0.49 4.95e-22 Glomerular filtration rate; LUSC cis rs9902453 1.000 rs9902453 chr17:28349095 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.81 -0.43 6.88e-17 Coffee consumption (cups per day); LUSC cis rs7224314 1.000 rs62084080 chr17:65387014 C/T cg01507342 chr17:65387096 PITPNC1 -0.45 -7.93 -0.4 3.28e-14 Diisocyanate-induced asthma; LUSC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 11.69 0.54 1.09e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10875746 0.903 rs11168414 chr12:48512331 C/T cg13454099 chr12:49076203 C12orf41 -0.5 -5.89 -0.31 9.66e-9 Longevity (90 years and older); LUSC cis rs240764 0.621 rs11752659 chr6:101212241 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.41 -0.33 5.02e-10 Neuroticism; LUSC cis rs2439831 0.867 rs16957632 chr15:43642897 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg27661571 chr11:113659931 NA -0.7 -7.97 -0.4 2.45e-14 Hip circumference adjusted for BMI; LUSC cis rs8060686 0.920 rs111315946 chr16:67889793 G/C cg27539214 chr16:67997921 SLC12A4 -0.46 -5.99 -0.31 5.44e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9302635 0.513 rs8061459 chr16:72156063 C/T cg01557791 chr16:72042693 DHODH -0.47 -6.0 -0.31 5.11e-9 Blood protein levels; LUSC cis rs9467773 1.000 rs1321480 chr6:26532742 A/G cg09904177 chr6:26538194 HMGN4 0.76 14.41 0.62 5.81e-37 Intelligence (multi-trait analysis); LUSC trans rs7824557 0.767 rs2164272 chr8:11162496 A/C cg08975724 chr8:8085496 FLJ10661 0.45 6.67 0.34 1.09e-10 Retinal vascular caliber; LUSC cis rs295140 1.000 rs7599609 chr2:201177653 G/A cg04283868 chr2:201171347 SPATS2L 0.42 6.38 0.33 5.75e-10 QT interval; LUSC cis rs9420 0.961 rs11606396 chr11:57435211 C/T cg02958346 chr11:57425731 CLP1 -0.43 -6.21 -0.32 1.59e-9 Schizophrenia; LUSC cis rs6960043 0.818 rs4719433 chr7:15065003 A/G cg19272540 chr7:15055459 NA -0.31 -7.71 -0.39 1.46e-13 Type 2 diabetes; LUSC cis rs17401966 1.000 rs11576866 chr1:10414432 A/G cg19773385 chr1:10388646 KIF1B -0.54 -8.29 -0.41 2.74e-15 Hepatocellular carcinoma; LUSC cis rs2486288 0.656 rs6493145 chr15:45573862 G/T cg09092052 chr15:45571596 NA 0.46 6.37 0.33 6.18e-10 Glomerular filtration rate; LUSC cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg05347473 chr6:146136440 FBXO30 0.56 9.71 0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs950776 0.518 rs4887063 chr15:78839715 C/T cg06917634 chr15:78832804 PSMA4 -0.7 -11.88 -0.54 2.22e-27 Sudden cardiac arrest; LUSC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg24675658 chr1:53192096 ZYG11B 0.75 12.9 0.58 3.69e-31 Monocyte count; LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg15790184 chr11:494944 RNH1 0.54 6.17 0.32 2e-9 Body mass index; LUSC cis rs7000551 0.689 rs7007673 chr8:22316687 G/T cg12081754 chr8:22256438 SLC39A14 0.44 6.57 0.34 1.89e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -7.98 -0.4 2.41e-14 Developmental language disorder (linguistic errors); LUSC trans rs12458462 0.812 rs34583578 chr18:77491070 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -6.23 -0.32 1.4e-9 Monocyte count; LUSC trans rs2262909 0.962 rs409835 chr19:22230671 T/C cg17074339 chr11:11642133 GALNTL4 -0.46 -7.07 -0.36 9.1e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg23385854 chr11:62623264 SNORD27;SLC3A2;SNORD26;SNORD28;SNORD25;SNHG1 -0.41 -6.1 -0.32 2.89e-9 Calcium levels; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.34 -0.42 1.94e-15 Lymphocyte counts; LUSC cis rs17789174 0.951 rs12596553 chr16:85104752 G/T cg01715842 chr16:85045600 ZDHHC7 -0.4 -5.64 -0.3 3.57e-8 Dysphagia; LUSC cis rs7659604 0.521 rs13130789 chr4:122690166 G/A cg06713675 chr4:122721982 EXOSC9 0.37 6.0 0.31 4.99e-9 Type 2 diabetes; LUSC cis rs870825 0.616 rs14969 chr4:185615764 C/A cg04058563 chr4:185651563 MLF1IP 0.86 13.29 0.59 1.2e-32 Blood protein levels; LUSC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg15839431 chr19:19639596 YJEFN3 0.65 6.94 0.36 2.01e-11 Bipolar disorder; LUSC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg21285383 chr16:89894308 SPIRE2 0.36 7.77 0.39 9.97e-14 Vitiligo; LUSC cis rs2282300 0.739 rs1222208 chr11:30361377 A/C cg25418670 chr11:30344373 C11orf46 -0.65 -9.34 -0.46 1.4e-18 Morning vs. evening chronotype; LUSC cis rs642803 0.613 rs489574 chr11:65542739 C/T cg27068330 chr11:65405492 SIPA1 0.58 7.82 0.39 6.93e-14 Urate levels; LUSC trans rs1005277 0.528 rs2057228 chr10:38515766 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.5 -0.46 4.09e-19 Extrinsic epigenetic age acceleration; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg04944784 chr2:26401820 FAM59B 0.77 11.36 0.53 1.68e-25 Gut microbiome composition (summer); LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg25811766 chr13:21894605 NA 0.68 11.48 0.53 6.2e-26 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg24060327 chr5:131705240 SLC22A5 -0.4 -6.54 -0.34 2.3e-10 Blood metabolite levels; LUSC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg13072238 chr3:49761600 GMPPB 0.63 7.65 0.39 2.14e-13 Menarche (age at onset); LUSC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg16624210 chr5:671434 TPPP 0.5 6.47 0.33 3.58e-10 Obesity-related traits; LUSC cis rs921665 0.831 rs2305491 chr2:3198175 C/T cg02624386 chr2:3182749 NA 0.59 6.6 0.34 1.59e-10 World class endurance athleticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17955752 chr17:79935872 ASPSCR1 -0.41 -6.02 -0.31 4.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7246657 0.943 rs1015849 chr19:37946180 G/A cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC trans rs2018683 0.600 rs6948880 chr7:29003478 C/T cg19402173 chr7:128379420 CALU -0.48 -7.29 -0.37 2.21e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg14019146 chr3:50243930 SLC38A3 0.31 6.78 0.35 5.6e-11 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg23711669 chr6:146136114 FBXO30 -0.89 -16.38 -0.67 1.09e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.767 rs1897951 chr8:11169854 C/T cg21293242 chr8:11204541 TDH 0.32 5.91 0.31 8.66e-9 Retinal vascular caliber; LUSC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg17366294 chr4:99064904 C4orf37 0.6 10.65 0.5 5.59e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2486288 0.656 rs6493144 chr15:45573489 C/G cg14582100 chr15:45693742 SPATA5L1 0.44 7.98 0.4 2.38e-14 Glomerular filtration rate; LUSC cis rs75920871 0.528 rs10082609 chr11:116949074 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.44 -0.33 4.19e-10 Subjective well-being; LUSC cis rs6121246 0.559 rs6060621 chr20:30261562 G/C cg13852791 chr20:30311386 BCL2L1 0.96 14.98 0.63 3.73e-39 Mean corpuscular hemoglobin; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg23131131 chr22:24373011 LOC391322 -0.41 -5.79 -0.3 1.65e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11690935 0.632 rs34531723 chr2:172564094 A/C cg13550731 chr2:172543902 DYNC1I2 0.6 9.6 0.46 2.03e-19 Schizophrenia; LUSC cis rs9393777 0.778 rs67457459 chr6:27198343 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -5.81 -0.3 1.43e-8 Intelligence (multi-trait analysis); LUSC trans rs853679 0.546 rs200990 chr6:27815823 T/G cg06606381 chr12:133084897 FBRSL1 -0.77 -7.75 -0.39 1.15e-13 Depression; LUSC cis rs7647973 0.769 rs4974081 chr3:49070499 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.62 -9.72 -0.47 7.74e-20 Menarche (age at onset); LUSC cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg01689657 chr7:91764605 CYP51A1 -0.34 -6.18 -0.32 1.84e-9 Breast cancer; LUSC cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg12219531 chr12:120966889 COQ5 0.58 7.85 0.39 5.83e-14 High light scatter reticulocyte count; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg11843238 chr5:131593191 PDLIM4 0.39 7.18 0.37 4.66e-12 Blood metabolite levels; LUSC cis rs7666738 0.546 rs1813970 chr4:98887167 A/G cg17366294 chr4:99064904 C4orf37 -0.51 -8.57 -0.42 4.01e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs34779708 0.966 rs4934539 chr10:35472199 A/G cg04310649 chr10:35416472 CREM -0.43 -6.74 -0.35 7.16e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg15110403 chr19:17392923 ANKLE1 -0.52 -7.29 -0.37 2.32e-12 Systemic lupus erythematosus; LUSC cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg24130564 chr14:104152367 KLC1 -0.42 -6.08 -0.32 3.38e-9 Body mass index; LUSC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg19747945 chr6:42946146 PEX6 -0.36 -5.88 -0.31 9.8e-9 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07926531 chr1:33546695 ADC -0.47 -6.13 -0.32 2.49e-9 Bipolar disorder and schizophrenia; LUSC trans rs1325195 0.879 rs2791940 chr1:179115485 C/T cg11624085 chr17:8464688 MYH10 0.42 6.89 0.35 2.76e-11 IgE grass sensitization; LUSC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.71 0.39 1.41e-13 Vitiligo; LUSC cis rs7804356 1.000 rs12532395 chr7:26841702 G/A cg03456212 chr7:26904342 SKAP2 -0.55 -6.47 -0.33 3.54e-10 Type 1 diabetes; LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs7580658 0.750 rs4497825 chr2:128061053 A/G cg09760422 chr2:128146352 NA -0.3 -6.8 -0.35 4.72e-11 Protein C levels; LUSC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg02423579 chr7:2872169 GNA12 -0.38 -5.75 -0.3 2.02e-8 Height; LUSC cis rs9443189 0.570 rs661229 chr6:76293793 G/A cg01950844 chr6:76311363 SENP6 0.7 6.98 0.36 1.63e-11 Prostate cancer; LUSC cis rs8038465 0.571 rs7176654 chr15:73999006 C/T cg15420318 chr15:73925796 NPTN -0.47 -7.66 -0.39 2.01e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7759001 0.817 rs1534937 chr6:27354335 A/T cg18711553 chr6:27366782 ZNF391 0.39 5.78 0.3 1.73e-8 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg23711669 chr6:146136114 FBXO30 -0.87 -16.34 -0.67 1.56e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs4906332 1.000 rs12879663 chr14:103874215 A/G cg04998671 chr14:104000505 TRMT61A -0.43 -6.53 -0.34 2.52e-10 Coronary artery disease; LUSC cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.91 0.31 8.5e-9 Rheumatoid arthritis; LUSC cis rs73195822 0.506 rs55948838 chr12:111142793 C/T cg12870014 chr12:110450643 ANKRD13A 0.67 7.4 0.38 1.13e-12 Itch intensity from mosquito bite; LUSC cis rs1371867 0.846 rs2439460 chr8:101312665 C/T cg06636551 chr8:101224915 SPAG1 -0.4 -7.41 -0.38 1.03e-12 Atrioventricular conduction; LUSC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg19592336 chr6:28129416 ZNF389 0.45 6.0 0.31 5.12e-9 Depression; LUSC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg09640425 chr7:158790006 NA 0.38 6.22 0.32 1.49e-9 Facial morphology (factor 20); LUSC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg00343986 chr7:65444356 GUSB 0.47 7.04 0.36 1.08e-11 Aortic root size; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg23758822 chr17:41437982 NA 1.06 20.2 0.74 7.16e-60 Menopause (age at onset); LUSC cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg13531842 chr10:38383804 ZNF37A -0.45 -7.02 -0.36 1.21e-11 Extrinsic epigenetic age acceleration; LUSC cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.03 -0.36 1.17e-11 Colorectal cancer; LUSC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg12963246 chr6:28129442 ZNF389 0.49 6.65 0.34 1.21e-10 Depression; LUSC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg21724239 chr8:58056113 NA 0.59 6.83 0.35 3.92e-11 Developmental language disorder (linguistic errors); LUSC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg09650180 chr20:62225654 GMEB2 -0.66 -9.42 -0.46 7.76e-19 Glioblastoma; LUSC cis rs56804039 1.000 rs67611618 chr8:8380939 T/C cg15556689 chr8:8085844 FLJ10661 -0.56 -6.96 -0.36 1.84e-11 Cervical cancer; LUSC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21582582 chr3:182698605 DCUN1D1 0.47 8.38 0.42 1.51e-15 Intelligence (multi-trait analysis); LUSC cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg13010199 chr12:38710504 ALG10B 0.68 11.27 0.52 3.61e-25 Heart rate; LUSC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg02187348 chr16:89574699 SPG7 0.65 10.74 0.51 2.56e-23 Multiple myeloma (IgH translocation); LUSC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg12463550 chr7:65579703 CRCP 0.62 5.67 0.3 3.04e-8 Diabetic kidney disease; LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg02951883 chr7:2050386 MAD1L1 -0.35 -5.9 -0.31 8.73e-9 Bipolar disorder and schizophrenia; LUSC cis rs2370759 0.891 rs11592754 chr10:32619572 A/C cg01819863 chr10:32635814 EPC1 1.06 11.03 0.52 2.54e-24 Sexual dysfunction (female); LUSC cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg07828340 chr4:882639 GAK -0.92 -10.22 -0.49 1.66e-21 Intelligence (multi-trait analysis); LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg13397359 chr6:42928475 GNMT 0.56 9.49 0.46 4.38e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1185460 0.967 rs1784461 chr11:118937985 G/A cg23280166 chr11:118938394 VPS11 0.48 7.64 0.39 2.27e-13 Coronary artery disease; LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg24675658 chr1:53192096 ZYG11B -0.56 -8.61 -0.43 2.86e-16 Monocyte count; LUSC cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg24642439 chr20:33292090 TP53INP2 -0.46 -6.85 -0.35 3.53e-11 Glomerular filtration rate (creatinine); LUSC cis rs9612 1.000 rs3786954 chr19:44272346 A/G cg08581076 chr19:44259116 C19orf61 0.49 6.18 0.32 1.86e-9 Exhaled nitric oxide output; LUSC cis rs433852 0.904 rs8102492 chr19:49140809 A/C cg06677660 chr19:49140777 SEC1;DBP 0.58 6.89 0.35 2.74e-11 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs16895831 0.583 rs62414592 chr6:42516867 G/A cg10605015 chr6:42532144 UBR2 -0.51 -6.12 -0.32 2.64e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -15.05 -0.64 1.86e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs4242434 0.927 rs11136092 chr8:22466488 T/G cg03733263 chr8:22462867 KIAA1967 0.97 16.82 0.68 1.99e-46 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2348418 0.831 rs2348416 chr12:28709216 C/G cg13890972 chr12:28721907 NA -0.37 -6.26 -0.32 1.21e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg25554036 chr4:6271136 WFS1 0.59 12.03 0.55 6.13e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg00701064 chr4:6280414 WFS1 0.59 14.6 0.62 1.11e-37 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs10751667 0.643 rs11246348 chr11:939476 G/C ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs11608355 0.597 rs9943699 chr12:109840876 G/C cg19025524 chr12:109796872 NA -0.47 -8.76 -0.43 9.63e-17 Neuroticism; LUSC cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg05347473 chr6:146136440 FBXO30 0.54 9.24 0.45 2.91e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs17539620 0.624 rs62432743 chr6:154836214 T/G cg20019720 chr6:154832845 CNKSR3 0.62 8.72 0.43 1.34e-16 Lipoprotein (a) levels; LUSC cis rs6690583 0.623 rs12042910 chr1:85452580 G/A cg22153463 chr1:85462885 MCOLN2 0.62 6.0 0.31 5.12e-9 Serum sulfate level; LUSC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg18131467 chr2:239335373 ASB1 1.03 24.53 0.8 1e-76 Multiple system atrophy; LUSC cis rs12200560 0.505 rs211163 chr6:97067654 A/G cg06623918 chr6:96969491 KIAA0776 0.49 7.03 0.36 1.2e-11 Coronary heart disease; LUSC cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg12573674 chr2:1569213 NA -0.64 -8.84 -0.44 5.53e-17 Placebo response in major depressive disorder (% change in symptom score); LUSC trans rs7937682 0.889 rs497111 chr11:111499512 G/A cg18187862 chr3:45730750 SACM1L 0.55 7.05 0.36 1.03e-11 Primary sclerosing cholangitis; LUSC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg18827107 chr12:86230957 RASSF9 -0.5 -7.49 -0.38 6.22e-13 Major depressive disorder; LUSC cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.73e-15 Homoarginine levels; LUSC cis rs12762955 0.608 rs7922760 chr10:1156815 G/C cg18964960 chr10:1102726 WDR37 -0.47 -6.31 -0.33 8.82e-10 Response to angiotensin II receptor blocker therapy; LUSC trans rs6445525 0.967 rs6782159 chr3:65993782 C/G cg04367164 chr11:76902992 MYO7A -0.3 -5.98 -0.31 5.74e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2617583 0.967 rs2550946 chr5:1450513 A/G cg07148919 chr5:1466943 LPCAT1 0.39 5.92 0.31 7.94e-9 Breast cancer; LUSC cis rs763121 0.719 rs138699 chr22:39129708 G/A cg14440974 chr22:39074834 NA -0.37 -5.95 -0.31 6.66e-9 Menopause (age at onset); LUSC cis rs11585357 0.947 rs2977303 chr1:17611548 A/T cg08277548 chr1:17600880 PADI3 -0.65 -7.22 -0.37 3.43e-12 Hair shape; LUSC cis rs7523050 0.643 rs35662800 chr1:109400816 C/A cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg10053473 chr17:62856997 LRRC37A3 -0.58 -9.05 -0.44 1.19e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs853679 0.542 rs9380063 chr6:28137853 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.54 -7.06 -0.36 9.65e-12 Mean platelet volume; LUSC cis rs7607369 0.580 rs17573731 chr2:219652153 T/C cg02176678 chr2:219576539 TTLL4 -0.67 -13.25 -0.59 1.7e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs1372520 0.684 rs2583963 chr4:90727088 C/T cg15133208 chr4:90757351 SNCA -0.55 -8.63 -0.43 2.6e-16 Neuroticism; LUSC cis rs911119 0.955 rs35610040 chr20:23616469 T/C cg16589663 chr20:23618590 CST3 0.6 6.99 0.36 1.48e-11 Chronic kidney disease; LUSC cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg05738196 chr6:26577821 NA 0.68 11.5 0.53 5.01e-26 Intelligence (multi-trait analysis); LUSC trans rs4332037 0.539 rs56180486 chr7:2050747 C/T cg10840412 chr1:235813424 GNG4 0.57 7.35 0.37 1.49e-12 Bipolar disorder; LUSC cis rs2219968 0.962 rs6473079 chr8:78928787 A/G cg00738934 chr8:78996279 NA 0.39 7.08 0.36 8.46e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7481584 0.624 rs421196 chr11:3048582 T/G cg05729581 chr11:3078854 CARS 0.39 5.82 0.3 1.4e-8 Calcium levels; LUSC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg05234568 chr11:5960015 NA -0.61 -8.77 -0.43 9.07e-17 DNA methylation (variation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10518340 chr6:97731094 MIR548H3;C6orf167 -0.43 -6.38 -0.33 5.77e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2463822 1.000 rs115395195 chr11:62100353 G/A cg06239285 chr11:62104954 ASRGL1 -0.96 -10.25 -0.49 1.29e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9473147 0.543 rs13211285 chr6:47479618 C/T cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.37 -6.29 -0.33 1.02e-9 High light scatter reticulocyte count; LUSC cis rs1448094 0.617 rs2221319 chr12:86468064 C/A cg02569458 chr12:86230093 RASSF9 -0.35 -5.67 -0.3 3.09e-8 Major depressive disorder; LUSC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg22823121 chr1:150693482 HORMAD1 0.58 8.97 0.44 2.13e-17 Tonsillectomy; LUSC cis rs9393692 0.645 rs28446029 chr6:26305801 C/G cg13736514 chr6:26305472 NA -0.54 -10.49 -0.5 1.96e-22 Educational attainment; LUSC cis rs400736 0.894 rs172811 chr1:8039949 A/G cg25007680 chr1:8021821 PARK7 0.58 9.18 0.45 4.47e-18 Response to antidepressants and depression; LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg06873352 chr17:61820015 STRADA 0.73 13.0 0.58 1.55e-31 Prudent dietary pattern; LUSC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg12379764 chr21:47803548 PCNT -0.5 -7.02 -0.36 1.28e-11 Testicular germ cell tumor; LUSC cis rs72717009 0.825 rs9427399 chr1:161476533 T/C cg23840854 chr1:161414152 NA -0.92 -11.2 -0.52 6.13e-25 Rheumatoid arthritis; LUSC trans rs34421088 0.576 rs2572437 chr8:11098441 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.42 -0.33 4.78e-10 Neuroticism; LUSC trans rs2055729 0.645 rs12543685 chr8:9747056 T/C cg06636001 chr8:8085503 FLJ10661 0.51 6.47 0.33 3.58e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs11792861 0.566 rs966466 chr9:111851333 T/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.08 0.36 8.49e-12 Menarche (age at onset); LUSC cis rs727505 1.000 rs7777947 chr7:124436063 T/G cg23710748 chr7:124431027 NA -0.4 -7.25 -0.37 3.01e-12 Lewy body disease; LUSC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg07747251 chr5:1868357 NA 0.3 5.71 0.3 2.44e-8 Cardiovascular disease risk factors; LUSC cis rs9875589 0.509 rs4685062 chr3:14066409 T/C cg19554555 chr3:13937349 NA -0.38 -5.71 -0.3 2.47e-8 Ovarian reserve; LUSC cis rs931127 0.719 rs11227259 chr11:65459404 T/C cg05805236 chr11:65401703 PCNXL3 -0.41 -7.17 -0.37 4.98e-12 Systemic lupus erythematosus; LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03576123 chr11:487126 PTDSS2 -1.01 -10.65 -0.5 5.17e-23 Body mass index; LUSC cis rs10823500 0.777 rs10999196 chr10:71982305 T/C cg02100629 chr10:71892760 AIFM2 -0.36 -5.86 -0.31 1.12e-8 Blood protein levels; LUSC cis rs3540 0.574 rs2657946 chr15:90967513 G/C cg10434728 chr15:90938212 IQGAP1 0.4 8.21 0.41 4.78e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7705502 1.000 rs966544 chr5:173350405 A/G cg18693985 chr5:173351052 CPEB4 -0.37 -5.86 -0.31 1.13e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs8028313 0.630 rs7169086 chr15:67934454 C/T cg08079166 chr15:68083412 MAP2K5 0.35 5.96 0.31 6.51e-9 Obesity; LUSC cis rs826838 0.904 rs1554550 chr12:39208889 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.82 0.51 1.4e-23 Heart rate; LUSC trans rs62458065 0.640 rs10274556 chr7:32513947 A/G cg00845942 chr12:64062724 DPY19L2 -0.57 -6.91 -0.35 2.5e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs3820068 0.637 rs4646080 chr1:15826627 A/T cg17385448 chr1:15911702 AGMAT 0.37 5.86 0.31 1.08e-8 Systolic blood pressure; LUSC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg23887609 chr12:130822674 PIWIL1 0.49 7.34 0.37 1.64e-12 Menopause (age at onset); LUSC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs10750766 1 rs10750766 chr11:65473798 C/A cg24468199 chr11:65410028 SIPA1 0.37 5.74 0.3 2.09e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23564928 chr14:32030597 NUBPL 0.43 6.33 0.33 7.86e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg13114125 chr14:105738426 BRF1 -0.94 -16.08 -0.66 1.69e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs7178572 0.568 rs11858641 chr15:77585820 C/T cg22256960 chr15:77711686 NA -0.5 -8.02 -0.4 1.83e-14 Type 2 diabetes; LUSC cis rs2073300 1.000 rs6132631 chr20:23461848 T/C cg09953122 chr20:23471693 CST8 -0.76 -7.49 -0.38 6.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9467711 0.606 rs9357006 chr6:26364628 A/C cg09904177 chr6:26538194 HMGN4 -0.71 -6.8 -0.35 4.92e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs478304 0.651 rs4930312 chr11:65499719 G/A cg10604040 chr11:65559109 OVOL1 0.31 5.72 0.3 2.34e-8 Acne (severe); LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg07092213 chr7:1199455 ZFAND2A -0.52 -7.96 -0.4 2.67e-14 Longevity;Endometriosis; LUSC cis rs79349575 0.783 rs903567 chr17:46980318 C/T cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs13114435 0.723 rs3886768 chr4:183817324 A/G cg00486011 chr4:183851557 NA -0.32 -5.77 -0.3 1.85e-8 Obesity-related traits; LUSC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg12463550 chr7:65579703 CRCP 0.56 8.38 0.42 1.53e-15 Aortic root size; LUSC cis rs2012796 1.000 rs12436146 chr14:81821282 A/G cg02996355 chr14:81879375 NA 0.5 7.24 0.37 3.08e-12 Night sleep phenotypes; LUSC cis rs611744 0.647 rs579162 chr8:109254842 A/G cg21045802 chr8:109455806 TTC35 0.43 6.6 0.34 1.58e-10 Dupuytren's disease; LUSC cis rs12476592 0.602 rs262506 chr2:63863022 A/G cg10828910 chr2:63850056 LOC388955 0.49 5.78 0.3 1.71e-8 Childhood ear infection; LUSC cis rs9905704 0.918 rs9891129 chr17:56630474 T/C cg12560992 chr17:57184187 TRIM37 -0.55 -7.81 -0.39 7.44e-14 Testicular germ cell tumor; LUSC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg14196790 chr5:131705035 SLC22A5 -0.42 -6.82 -0.35 4.3e-11 Breast cancer;Mosquito bite size; LUSC cis rs483180 0.531 rs662243 chr1:120209564 A/C cg19096424 chr1:120255104 PHGDH 0.47 6.58 0.34 1.83e-10 Macular telangiectasia type 2; LUSC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 9.28 0.45 2.17e-18 Menopause (age at onset); LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg06873352 chr17:61820015 STRADA 0.73 13.13 0.58 4.77e-32 Prudent dietary pattern; LUSC cis rs10823500 0.545 rs7082562 chr10:71945684 A/G cg02100629 chr10:71892760 AIFM2 -0.36 -6.1 -0.32 2.91e-9 Blood protein levels; LUSC cis rs7712401 0.601 rs246282 chr5:122225605 G/T cg19077854 chr5:122220652 SNX24 0.4 8.76 0.43 9.9900000000000006e-17 Mean platelet volume; LUSC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.63 -0.34 1.33e-10 Alzheimer's disease (late onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04915425 chr11:47236385 DDB2 -0.44 -6.04 -0.31 4.13e-9 Hepatitis; LUSC cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.12e-11 Height; LUSC cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.07 0.48 5.45e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs629535 0.814 rs674429 chr8:70069942 G/A cg21567404 chr3:27674614 NA 0.98 15.66 0.65 7.7e-42 Dupuytren's disease; LUSC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg10295955 chr4:187884368 NA -1.08 -26.06 -0.82 1.7e-82 Lobe attachment (rater-scored or self-reported); LUSC cis rs208520 0.526 rs7776413 chr6:66783241 A/G cg07460842 chr6:66804631 NA -1.26 -27.67 -0.83 2e-88 Exhaled nitric oxide output; LUSC cis rs6982240 0.514 rs10481414 chr8:142275326 T/C cg27411547 chr8:142287226 NA -0.47 -8.02 -0.4 1.77e-14 Tonsillectomy; LUSC cis rs7592578 0.771 rs1128723 chr2:191366707 A/G cg10560079 chr2:191398806 TMEM194B -0.74 -9.0 -0.44 1.73e-17 Diastolic blood pressure; LUSC cis rs11122272 0.735 rs2247124 chr1:231493687 A/G cg06096015 chr1:231504339 EGLN1 0.58 10.12 0.48 3.46e-21 Hemoglobin concentration; LUSC cis rs1506636 0.962 rs10243279 chr7:123441262 T/A cg03229431 chr7:123269106 ASB15 0.63 10.15 0.49 2.75e-21 Plateletcrit;Platelet count; LUSC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg20476274 chr7:133979776 SLC35B4 0.87 16.82 0.68 2e-46 Mean platelet volume; LUSC cis rs7617480 0.616 rs9873227 chr3:48773108 G/C cg21141812 chr3:48556323 PFKFB4 0.35 6.02 0.31 4.54e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs12421382 0.593 rs2357793 chr11:109389353 A/T cg11473876 chr11:109292803 C11orf87 0.35 5.97 0.31 5.95e-9 Schizophrenia; LUSC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg06740227 chr12:86229804 RASSF9 0.44 7.09 0.36 7.84e-12 Major depressive disorder; LUSC cis rs7119167 0.686 rs12294659 chr11:73041007 G/A cg17517138 chr11:73019481 ARHGEF17 0.5 5.85 0.3 1.16e-8 Blood protein levels; LUSC cis rs2760061 0.784 rs1745414 chr1:228212159 T/A cg01973587 chr1:228161476 NA -0.41 -7.23 -0.37 3.38e-12 Diastolic blood pressure; LUSC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg12639453 chr1:2035780 PRKCZ 0.3 6.38 0.33 6.06e-10 Height; LUSC trans rs61931739 0.517 rs10844802 chr12:34231001 C/A cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.35e-16 Morning vs. evening chronotype; LUSC cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg08807101 chr21:30365312 RNF160 -0.76 -13.42 -0.59 3.81e-33 Dental caries; LUSC cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.92 0.4 3.59e-14 Colorectal cancer; LUSC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg26695010 chr11:65641043 EFEMP2 -0.47 -6.93 -0.35 2.18e-11 Eosinophil percentage of white cells; LUSC cis rs7267979 0.903 rs2500400 chr20:25354705 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.27 -0.71 3.63e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9469578 1.000 rs6923565 chr6:33707112 G/A cg18708504 chr6:33715942 IP6K3 0.72 9.01 0.44 1.58e-17 Phosphorus levels; LUSC cis rs7107174 0.901 rs10899494 chr11:78122208 G/T cg02023728 chr11:77925099 USP35 0.44 6.41 0.33 5.04e-10 Testicular germ cell tumor; LUSC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg01579765 chr21:45077557 HSF2BP -0.53 -11.15 -0.52 9.06e-25 Mean corpuscular volume; LUSC cis rs6951245 0.882 rs10252404 chr7:1209607 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.48 -6.33 -0.33 8.07e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7927592 0.913 rs7104345 chr11:68316772 G/A cg20283391 chr11:68216788 NA -0.61 -8.46 -0.42 8.4e-16 Total body bone mineral density; LUSC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg13877915 chr19:58951672 ZNF132 0.49 7.75 0.39 1.11e-13 Uric acid clearance; LUSC cis rs2073300 0.609 rs1076776 chr20:23427399 C/T cg12062639 chr20:23401060 NAPB -0.93 -8.41 -0.42 1.2e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2742234 0.794 rs17153156 chr10:43704637 C/G cg02780029 chr10:43622663 RET 0.32 6.22 0.32 1.51e-9 Hirschsprung disease; LUSC trans rs1268789 0.545 rs11730871 chr4:79368816 T/C cg06112894 chr8:141469983 TRAPPC9 0.22 5.96 0.31 6.33e-9 Hair shape;Hair morphology; LUSC cis rs897080 0.515 rs4953088 chr2:44564518 C/T cg00619915 chr2:44497795 NA 0.4 5.89 0.31 9.52e-9 Height; LUSC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg02569458 chr12:86230093 RASSF9 0.47 7.47 0.38 6.9e-13 Major depressive disorder; LUSC cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.39 -6.35 -0.33 6.98e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg08280861 chr8:58055591 NA 0.55 6.51 0.34 2.79e-10 Developmental language disorder (linguistic errors); LUSC cis rs208520 0.779 rs208446 chr6:66903515 T/C cg07460842 chr6:66804631 NA -0.96 -12.87 -0.58 4.54e-31 Exhaled nitric oxide output; LUSC trans rs10096351 0.528 rs74588857 chr8:128336741 C/T cg10897648 chr18:56338258 MALT1 -0.42 -6.24 -0.32 1.33e-9 Breast cancer; LUSC cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.31e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg13010344 chr12:123464640 ARL6IP4 -0.47 -7.1 -0.36 7.72e-12 Neutrophil percentage of white cells; LUSC cis rs3008870 0.959 rs2985810 chr1:67376162 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.36 0.64 1.2e-40 Lymphocyte percentage of white cells; LUSC cis rs10492096 0.947 rs10849483 chr12:6635374 G/A cg13857086 chr12:6580257 VAMP1 0.64 7.69 0.39 1.64e-13 Hip geometry; LUSC cis rs10504229 0.679 rs16921683 chr8:58053270 T/C cg22535103 chr8:58192502 C8orf71 -0.57 -6.54 -0.34 2.29e-10 Developmental language disorder (linguistic errors); LUSC cis rs757081 0.667 rs17560341 chr11:17107163 C/T cg15432903 chr11:17409602 KCNJ11 -0.39 -6.02 -0.31 4.54e-9 Systolic blood pressure; LUSC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg21665744 chr7:39171113 POU6F2 0.47 7.56 0.38 3.96e-13 IgG glycosylation; LUSC cis rs11622475 0.677 rs7145372 chr14:104359121 A/G cg12183467 chr14:104352244 NA 0.46 9.26 0.45 2.55e-18 Bipolar disorder; LUSC cis rs3947 0.855 rs1296026 chr8:11697442 C/T cg00262122 chr8:11665843 FDFT1 -0.48 -5.66 -0.3 3.32e-8 Blood protein levels; LUSC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg06637938 chr14:75390232 RPS6KL1 0.54 8.62 0.43 2.76e-16 Height; LUSC cis rs1008375 0.933 rs4698637 chr4:17632843 A/T cg16339924 chr4:17578868 LAP3 0.58 8.72 0.43 1.36e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.96 0.44 2.3e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg02269571 chr22:50332266 NA -0.57 -8.4 -0.42 1.26e-15 Schizophrenia; LUSC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg11752832 chr7:134001865 SLC35B4 0.56 8.64 0.43 2.38e-16 Mean platelet volume; LUSC trans rs1325195 0.537 rs2793807 chr1:179171713 C/T cg11624085 chr17:8464688 MYH10 0.43 6.38 0.33 5.94e-10 IgE grass sensitization; LUSC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg17366294 chr4:99064904 C4orf37 0.58 10.24 0.49 1.42e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.507 rs6061999 chr20:60637429 G/A cg06108461 chr20:60628389 TAF4 -0.76 -12.65 -0.57 3.18e-30 Body mass index; LUSC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg07701084 chr6:150067640 NUP43 -0.55 -8.38 -0.42 1.46e-15 Lung cancer; LUSC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.34 -6.98 -0.36 1.6e-11 Hemoglobin concentration; LUSC cis rs10465746 0.967 rs11576870 chr1:84333301 G/A cg10977910 chr1:84465055 TTLL7 0.45 6.38 0.33 5.91e-10 Obesity-related traits; LUSC cis rs10761482 0.532 rs1938533 chr10:62234109 G/C cg18175470 chr10:62150864 ANK3 -0.48 -6.77 -0.35 5.77e-11 Schizophrenia; LUSC trans rs7178375 0.941 rs4779796 chr15:31208050 C/T cg04373760 chr16:53404718 NA 0.64 8.8 0.43 7.58e-17 Hypertriglyceridemia; LUSC cis rs7589342 0.831 rs13429270 chr2:106453060 C/T cg14210321 chr2:106509881 NCK2 -0.54 -8.04 -0.4 1.58e-14 Addiction; LUSC cis rs3849570 1.000 rs11915016 chr3:81833966 G/A cg07356753 chr3:81810745 GBE1 -0.68 -11.09 -0.52 1.46e-24 Waist circumference;Body mass index; LUSC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg06060754 chr5:176797920 RGS14 0.6 9.71 0.47 8.65e-20 Hemoglobin concentration;Hematocrit; LUSC cis rs7615316 0.902 rs6770155 chr3:142308691 A/G cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.61e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs708547 0.874 rs1614251 chr4:57891386 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 8.93 0.44 2.84e-17 Response to bleomycin (chromatid breaks); LUSC cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.1e-12 Motion sickness; LUSC cis rs911119 0.913 rs13038990 chr20:23589053 C/T cg16589663 chr20:23618590 CST3 0.56 6.77 0.35 5.68e-11 Chronic kidney disease; LUSC cis rs6500602 0.702 rs3789038 chr16:4546586 C/G cg08645402 chr16:4508243 NA -0.47 -7.26 -0.37 2.7e-12 Schizophrenia; LUSC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg19468946 chr17:37922297 IKZF3 -0.39 -6.22 -0.32 1.51e-9 Self-reported allergy; LUSC cis rs4820539 1.000 rs885963 chr22:23460939 G/T cg21100191 chr22:23484243 RTDR1 0.91 15.61 0.65 1.18e-41 Bone mineral density; LUSC trans rs10016947 0.826 rs6821736 chr4:104267560 T/A cg02356640 chr11:1501973 HCCA2 0.69 5.98 0.31 5.79e-9 Breast cancer; LUSC trans rs7726839 1.000 rs7726839 chr5:618586 A/G cg25482853 chr8:67687455 SGK3 0.65 9.56 0.46 2.63e-19 Obesity-related traits; LUSC trans rs9329221 0.736 rs11250002 chr8:10257041 T/G cg15556689 chr8:8085844 FLJ10661 0.56 7.89 0.4 4.31e-14 Neuroticism; LUSC cis rs9486715 0.929 rs7775721 chr6:97056979 C/T cg06623918 chr6:96969491 KIAA0776 -0.9 -15.28 -0.64 2.44e-40 Headache; LUSC trans rs2797160 0.967 rs1954360 chr6:126001064 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.16e-10 Endometrial cancer; LUSC cis rs12220238 1.000 rs1908331 chr10:75885817 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 7.69 0.39 1.65e-13 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs11630290 0.736 rs7183958 chr15:64155534 C/G cg12036633 chr15:63758958 NA -0.62 -6.85 -0.35 3.67e-11 Iris characteristics; LUSC cis rs644148 0.836 rs2686776 chr19:45000366 T/C cg15540054 chr19:45004280 ZNF180 -0.62 -9.16 -0.45 5.44e-18 Personality dimensions; LUSC cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg15423357 chr2:25149977 NA 0.45 9.03 0.44 1.37e-17 Body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20769334 chr22:50913335 SBF1 -0.53 -7.01 -0.36 1.29e-11 Bipolar disorder and schizophrenia; LUSC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg12615879 chr12:58013172 SLC26A10 -0.27 -5.77 -0.3 1.78e-8 Multiple sclerosis; LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.74 -0.65 3.74e-42 Gut microbiome composition (summer); LUSC cis rs4144743 1.000 rs67080286 chr17:45322248 T/G cg18085866 chr17:45331354 ITGB3 -0.73 -7.87 -0.4 4.93e-14 Body mass index; LUSC cis rs3820068 0.580 rs61169376 chr1:16003832 A/G cg13390004 chr1:15929781 NA 0.4 6.56 0.34 2.09e-10 Systolic blood pressure; LUSC cis rs9300255 0.602 rs4372492 chr12:123697357 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs12712073 0.837 rs11692867 chr2:100759477 G/A cg07810366 chr2:100720526 AFF3 -0.44 -7.53 -0.38 4.69e-13 Intelligence (multi-trait analysis); LUSC cis rs9329221 0.905 rs17709397 chr8:10249861 G/A cg27411982 chr8:10470053 RP1L1 -0.49 -7.85 -0.39 5.89e-14 Neuroticism; LUSC cis rs2652834 0.904 rs8032506 chr15:63371644 G/A cg05507819 chr15:63340323 TPM1 -0.66 -7.93 -0.4 3.36e-14 HDL cholesterol; LUSC cis rs7107174 1.000 rs2510039 chr11:77944480 G/A cg02023728 chr11:77925099 USP35 0.48 6.47 0.33 3.54e-10 Testicular germ cell tumor; LUSC trans rs1814175 0.645 rs28454367 chr11:50045708 G/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg06627628 chr2:24431161 ITSN2 0.61 7.36 0.37 1.45e-12 Lymphocyte counts; LUSC cis rs75920871 0.588 rs1815789 chr11:116834953 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.47 -0.33 3.57e-10 Subjective well-being; LUSC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg00074818 chr8:8560427 CLDN23 0.59 9.8 0.47 4.21e-20 Obesity-related traits; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg07217954 chr7:1067459 C7orf50 0.52 5.67 0.3 3.02e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs240764 0.645 rs454747 chr6:101055566 T/C cg09795085 chr6:101329169 ASCC3 0.41 5.9 0.31 9.09e-9 Neuroticism; LUSC cis rs11997175 0.574 rs4236733 chr8:33655582 G/A ch.8.33884649F chr8:33765107 NA 0.52 8.57 0.42 3.94e-16 Body mass index; LUSC cis rs2073300 0.793 rs6114094 chr20:23434267 A/G cg09953122 chr20:23471693 CST8 -0.69 -6.55 -0.34 2.13e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 14.3 0.62 1.66e-36 Platelet count; LUSC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg04450456 chr4:17643702 FAM184B 0.38 6.46 0.33 3.77e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1775715 0.513 rs2808089 chr10:32145112 A/T cg04359828 chr10:32216031 ARHGAP12 0.41 7.12 0.36 6.83e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg04450456 chr4:17643702 FAM184B -0.41 -6.51 -0.34 2.8e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6696846 0.749 rs6692170 chr1:205074019 G/A cg00857998 chr1:205179979 DSTYK 0.61 9.82 0.47 3.76e-20 Red blood cell count; LUSC cis rs453301 0.653 rs11784393 chr8:8903134 C/T cg15556689 chr8:8085844 FLJ10661 0.68 10.96 0.51 4.41e-24 Joint mobility (Beighton score); LUSC cis rs6964587 1.000 rs35653487 chr7:91745441 C/G cg17063962 chr7:91808500 NA 0.6 9.45 0.46 6.13e-19 Breast cancer; LUSC cis rs4290604 0.748 rs4621125 chr2:238080214 G/A cg23555395 chr2:238036564 NA -0.51 -6.89 -0.35 2.81e-11 Asthma; LUSC cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg00071950 chr4:10020882 SLC2A9 0.58 9.7 0.47 9.12e-20 Bone mineral density; LUSC cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg25072359 chr17:41440525 NA 0.66 9.44 0.46 6.54e-19 Menopause (age at onset); LUSC trans rs2262909 0.962 rs390730 chr19:22233509 C/A cg05197062 chr11:11642011 GALNTL4 -0.56 -7.81 -0.39 7.34e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg05313129 chr8:58192883 C8orf71 -0.58 -6.3 -0.33 9.65e-10 Developmental language disorder (linguistic errors); LUSC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg05802129 chr4:122689817 NA -0.48 -8.33 -0.41 2.06e-15 Type 2 diabetes; LUSC cis rs4285028 0.948 rs12493408 chr3:121692119 C/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.56 -0.46 2.57e-19 Multiple sclerosis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11206763 chr12:56521692 ESYT1 0.52 7.3 0.37 2.09e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7408868 0.908 rs10418660 chr19:15278635 A/G cg14696996 chr19:15285081 NOTCH3 0.97 9.33 0.45 1.56e-18 Pulse pressure; LUSC cis rs354225 0.544 rs13403284 chr2:54805749 A/G cg01766943 chr2:54829624 SPTBN1 0.48 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs2014572 0.967 rs10421632 chr19:57764770 G/A cg24459738 chr19:57751996 ZNF805 -0.5 -7.51 -0.38 5.36e-13 Hyperactive-impulsive symptoms; LUSC trans rs804280 0.542 rs36100659 chr8:11791653 A/T cg14343924 chr8:8086146 FLJ10661 0.44 6.11 0.32 2.74e-9 Myopia (pathological); LUSC cis rs1799949 0.794 rs116409325 chr17:41445460 C/A cg23758822 chr17:41437982 NA 1.03 19.9 0.74 1.14e-58 Menopause (age at onset); LUSC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg06808227 chr14:105710500 BRF1 -0.65 -9.82 -0.47 3.77e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs6681460 0.549 rs7525509 chr1:67031968 C/T cg02459107 chr1:67143332 SGIP1 0.31 5.69 0.3 2.85e-8 Presence of antiphospholipid antibodies; LUSC trans rs2392780 0.512 rs373701 chr8:128334992 C/A cg10195415 chr17:73887371 TRIM65 0.41 6.49 0.33 3.12e-10 Breast cancer (early onset); LUSC cis rs13089785 0.965 rs12488058 chr3:123599681 C/T cg02558132 chr3:123411198 MYLK 0.36 6.15 0.32 2.17e-9 Intelligence (multi-trait analysis); LUSC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.15 -0.36 5.59e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504073 0.584 rs7823690 chr8:49943831 G/A cg00325661 chr8:49890786 NA 0.69 11.04 0.52 2.2e-24 Blood metabolite ratios; LUSC trans rs7944735 0.786 rs7123436 chr11:48013484 G/A cg15704280 chr7:45808275 SEPT13 0.63 6.56 0.34 2.07e-10 Intraocular pressure; LUSC cis rs3540 0.533 rs2256110 chr15:90971036 T/C cg03599575 chr15:90893182 GABARAPL3 0.33 5.91 0.31 8.3e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4704187 0.687 rs6888707 chr5:74442920 A/G cg03227963 chr5:74354835 NA 0.31 6.77 0.35 5.75e-11 Response to amphetamines; LUSC trans rs1728785 0.901 rs1170420 chr16:68635877 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.72 0.39 1.39e-13 Ulcerative colitis; LUSC cis rs981844 0.740 rs7653960 chr4:154697430 T/G cg14289246 chr4:154710475 SFRP2 -0.52 -7.16 -0.36 5.19e-12 Response to statins (LDL cholesterol change); LUSC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg14416269 chr4:6271139 WFS1 0.54 11.37 0.53 1.53e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7264396 0.790 rs6121015 chr20:34243017 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.85 -0.47 2.92e-20 Total cholesterol levels; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.9 0.77 1.58e-66 Prudent dietary pattern; LUSC trans rs561341 0.883 rs1034627 chr17:30219569 C/T cg20587970 chr11:113659929 NA -0.86 -10.81 -0.51 1.53e-23 Hip circumference adjusted for BMI; LUSC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg03929089 chr4:120376271 NA -0.94 -16.46 -0.67 5.66e-45 Height; LUSC cis rs57549656 0.799 rs1001328 chr19:2712016 G/C cg06609049 chr19:2785107 THOP1 0.49 6.31 0.33 8.64e-10 Schizophrenia; LUSC cis rs644799 0.648 rs1255176 chr11:95471465 A/T cg25622487 chr11:95524042 FAM76B;CEP57 0.49 6.98 0.36 1.63e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg05340658 chr4:99064831 C4orf37 0.67 11.29 0.53 2.91e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16656864 chr17:27718261 TAOK1 0.48 7.05 0.36 1e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg03732007 chr1:2071316 PRKCZ -0.53 -9.4 -0.46 9.09e-19 Height; LUSC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg16797656 chr11:68205561 LRP5 0.4 7.17 0.37 4.72e-12 Total body bone mineral density; LUSC cis rs908922 0.847 rs499697 chr1:152493154 A/G cg20991723 chr1:152506922 NA -0.51 -8.9 -0.44 3.55e-17 Hair morphology; LUSC cis rs9905704 0.918 rs581903 chr17:56719197 C/T cg12560992 chr17:57184187 TRIM37 0.55 7.85 0.39 5.74e-14 Testicular germ cell tumor; LUSC cis rs7617773 0.817 rs9819094 chr3:48319558 C/T cg20734569 chr3:48348370 SPINK8 -0.46 -8.24 -0.41 3.91e-15 Coronary artery disease; LUSC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -9.68 -0.47 1.11e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs1372520 0.684 rs1442148 chr4:90748846 T/A cg15133208 chr4:90757351 SNCA -0.53 -8.27 -0.41 3.2e-15 Neuroticism; LUSC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.98 0.55 9.22e-28 Hip circumference adjusted for BMI; LUSC cis rs4356932 1.000 rs10003240 chr4:76955330 C/T cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs7605827 0.893 rs7572131 chr2:15691886 G/A cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.32e-17 Educational attainment (years of education); LUSC cis rs60154123 0.772 rs614167 chr1:210425895 T/C cg22029157 chr1:209979665 IRF6 0.59 6.03 0.31 4.23e-9 Coronary artery disease; LUSC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg13206674 chr6:150067644 NUP43 0.59 9.05 0.44 1.19e-17 Lung cancer; LUSC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg09085632 chr11:111637200 PPP2R1B -1.06 -16.96 -0.68 5.39e-47 Primary sclerosing cholangitis; LUSC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg00745463 chr17:30367425 LRRC37B -0.8 -9.58 -0.46 2.23e-19 Hip circumference adjusted for BMI; LUSC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg21862992 chr11:68658383 NA 0.49 7.84 0.39 6.24e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7215564 0.908 rs7501497 chr17:78660738 T/C cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg24692254 chr21:30365293 RNF160 -0.84 -15.46 -0.65 4.96e-41 Dental caries; LUSC cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg23791538 chr6:167370224 RNASET2 0.41 6.53 0.34 2.39e-10 Crohn's disease; LUSC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg12310025 chr6:25882481 NA -0.5 -8.31 -0.41 2.46e-15 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.958 rs12208227 chr6:86670944 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.61 -0.34 1.52e-10 Response to antipsychotic treatment; LUSC cis rs2479724 0.846 rs2251084 chr6:41838119 T/C cg17623882 chr6:41773611 USP49 -0.59 -10.1 -0.48 4.14e-21 Menarche (age at onset); LUSC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg05717871 chr11:638507 DRD4 -0.36 -6.06 -0.31 3.76e-9 Systemic lupus erythematosus; LUSC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg02353165 chr6:42928485 GNMT -0.46 -5.81 -0.3 1.49e-8 Blood protein levels; LUSC cis rs6961069 0.585 rs12532196 chr7:80241570 T/C cg04458919 chr7:80252533 CD36 -0.39 -6.91 -0.35 2.41e-11 Platelet count; LUSC cis rs1577917 0.917 rs1584273 chr6:86524577 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs7927771 0.864 rs10838724 chr11:47527052 G/T cg05585544 chr11:47624801 NA -0.36 -6.3 -0.33 9.37e-10 Subjective well-being; LUSC cis rs28830936 0.966 rs2241522 chr15:42127734 A/G cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.69 -0.3 2.83e-8 Diastolic blood pressure; LUSC cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.85 0.39 5.8e-14 Height; LUSC cis rs11785400 0.928 rs10100287 chr8:143734836 C/T cg10596483 chr8:143751796 JRK 0.61 9.4 0.46 9.11e-19 Schizophrenia; LUSC cis rs753778 0.570 rs6985866 chr8:142210336 C/T cg18755752 chr8:142205143 DENND3 0.68 11.86 0.54 2.56e-27 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs9473147 0.516 rs9395279 chr6:47542864 C/T cg02130027 chr6:47444894 CD2AP 0.35 5.65 0.3 3.39e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs36405 0.500 rs2109273 chr14:72360964 C/T cg23396177 chr14:72358413 NA -0.37 -6.97 -0.36 1.69e-11 Yang-deficiency constitution; LUSC cis rs9287719 0.967 rs3815521 chr2:10743654 G/C cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg06656553 chr16:89960601 TCF25 -0.64 -5.66 -0.3 3.2e-8 Skin colour saturation; LUSC cis rs3020736 0.500 rs11090076 chr22:42514190 T/C cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs354225 0.544 rs13399656 chr2:54802696 T/G cg26097391 chr2:54893211 SPTBN1 0.43 6.33 0.33 7.75e-10 Schizophrenia; LUSC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg06008330 chr7:65541103 ASL -0.41 -6.31 -0.33 8.66e-10 Aortic root size; LUSC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg18827107 chr12:86230957 RASSF9 -0.46 -6.96 -0.36 1.81e-11 Major depressive disorder; LUSC cis rs2625529 0.824 rs12595228 chr15:72267215 T/C cg16672083 chr15:72433130 SENP8 -0.51 -7.39 -0.37 1.19e-12 Red blood cell count; LUSC cis rs2285947 1.000 rs6970597 chr7:21583519 C/A cg04471919 chr7:21584483 DNAH11 0.35 7.74 0.39 1.16e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC trans rs61931739 0.817 rs866515 chr12:34215479 A/G cg24313572 chr1:56050060 NA -0.31 -6.41 -0.33 4.89e-10 Morning vs. evening chronotype; LUSC cis rs295140 0.706 rs3769484 chr2:201172999 C/T cg04283868 chr2:201171347 SPATS2L 0.43 6.18 0.32 1.82e-9 QT interval; LUSC cis rs7927592 0.956 rs7944870 chr11:68309108 C/G cg01657329 chr11:68192670 LRP5 -0.42 -6.34 -0.33 7.46e-10 Total body bone mineral density; LUSC cis rs662735 0.515 rs273612 chr11:30903063 C/T cg14844989 chr11:31128820 NA 0.35 5.68 0.3 2.93e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg05855489 chr10:104503620 C10orf26 0.53 8.11 0.41 9.87e-15 Arsenic metabolism; LUSC cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.77e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6500395 0.962 rs7499213 chr16:48680597 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.41 0.33 4.93e-10 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07177001 chr8:22926478 TNFRSF10B 0.71 6.03 0.31 4.3e-9 Cognitive performance; LUSC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.27e-11 Lung cancer; LUSC cis rs7809950 0.954 rs2520242 chr7:107136320 G/T cg23024343 chr7:107201750 COG5 0.56 8.99 0.44 1.9e-17 Coronary artery disease; LUSC cis rs7241530 0.595 rs12954372 chr18:75900263 C/A cg14642773 chr18:75888474 NA 0.38 5.7 0.3 2.61e-8 Educational attainment (years of education); LUSC trans rs7618501 0.635 rs7635002 chr3:49989155 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.59 9.45 0.46 6e-19 Intelligence (multi-trait analysis); LUSC cis rs2882667 0.858 rs11959851 chr5:138421405 C/G cg04439458 chr5:138467593 SIL1 -0.41 -7.98 -0.4 2.29e-14 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs5758659 0.652 rs133349 chr22:42428727 A/T cg04733989 chr22:42467013 NAGA 0.42 7.08 0.36 8.61e-12 Cognitive function; LUSC cis rs2935183 1 rs2935183 chr17:45607572 T/G cg25173405 chr17:45401733 C17orf57 0.37 5.76 0.3 1.89e-8 Multiple sclerosis or amyotrophic lateral sclerosis; LUSC trans rs11098499 0.738 rs72918577 chr4:120326701 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.2 0.41 5.32e-15 Corneal astigmatism; LUSC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22307029 chr19:49891270 CCDC155 0.69 9.55 0.46 2.9e-19 Multiple sclerosis; LUSC cis rs4654899 1.000 rs6684976 chr1:21367501 G/A cg01072550 chr1:21505969 NA -0.56 -8.54 -0.42 4.74e-16 Superior frontal gyrus grey matter volume; LUSC cis rs7772486 0.837 rs2474354 chr6:146323795 T/A cg05347473 chr6:146136440 FBXO30 0.41 6.79 0.35 5.11e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs12620999 1.000 rs13004252 chr2:238035408 C/A cg23555395 chr2:238036564 NA -0.51 -8.12 -0.41 9.17e-15 Systemic lupus erythematosus; LUSC cis rs7577696 0.525 rs2366547 chr2:32251109 G/A cg02381751 chr2:32503542 YIPF4 -0.45 -6.07 -0.32 3.52e-9 Inflammatory biomarkers; LUSC cis rs2652834 0.851 rs2729813 chr15:63412154 A/G cg05507819 chr15:63340323 TPM1 0.46 5.94 0.31 7.3e-9 HDL cholesterol; LUSC cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg26647111 chr11:31128758 NA -0.42 -6.11 -0.32 2.7e-9 Red blood cell count; LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg12639453 chr1:2035780 PRKCZ -0.3 -6.3 -0.33 9.13e-10 Height; LUSC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg13206674 chr6:150067644 NUP43 0.62 9.73 0.47 7.45e-20 Lung cancer; LUSC cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg17892150 chr10:133769511 PPP2R2D -0.66 -9.18 -0.45 4.72e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg23281280 chr6:28129359 ZNF389 0.43 5.71 0.3 2.55e-8 Parkinson's disease; LUSC cis rs7819412 0.540 rs2409725 chr8:11041661 T/C cg21775007 chr8:11205619 TDH -0.47 -6.49 -0.33 3.09e-10 Triglycerides; LUSC cis rs7267979 1.000 rs6076345 chr20:25381895 T/G cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs6728642 0.908 rs6731522 chr2:97647997 A/G cg26665480 chr2:98280029 ACTR1B -0.69 -5.97 -0.31 6.02e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs6121246 0.528 rs6060252 chr20:30191084 A/G cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg07274523 chr3:49395745 GPX1 0.67 10.27 0.49 1.11e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs12891047 0.901 rs11621019 chr14:68269435 T/C cg20999565 chr14:68265668 ZFYVE26 0.38 5.67 0.3 3.06e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6009527 0.711 rs8141990 chr22:49570455 T/G cg12746016 chr22:49560550 NA 0.48 8.74 0.43 1.17e-16 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs10744422 1.000 rs10744434 chr12:123368419 T/A cg25930673 chr12:123319894 HIP1R -0.62 -6.11 -0.32 2.79e-9 Schizophrenia; LUSC cis rs2650000 0.798 rs2701175 chr12:121391671 C/A cg25281562 chr12:121454272 C12orf43 -0.43 -5.69 -0.3 2.84e-8 Metabolic traits;LDL cholesterol; LUSC cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.56 9.45 0.46 6.08e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7580658 0.724 rs6712446 chr2:127998399 G/T cg09760422 chr2:128146352 NA -0.3 -6.79 -0.35 5.27e-11 Protein C levels; LUSC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg12463550 chr7:65579703 CRCP -0.55 -8.23 -0.41 4.27e-15 Aortic root size; LUSC cis rs763014 1.000 rs763014 chr16:675680 T/C cg00908189 chr16:619842 PIGQ 0.66 10.21 0.49 1.81e-21 Height; LUSC cis rs59698941 0.943 rs67422135 chr5:132222728 T/A cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.45e-11 Apolipoprotein A-IV levels; LUSC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg02551604 chr5:131831745 NA 0.43 6.8 0.35 4.74e-11 Asthma (sex interaction); LUSC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg00343986 chr7:65444356 GUSB 0.47 7.01 0.36 1.35e-11 Calcium levels; LUSC cis rs710216 0.957 rs3738514 chr1:43426591 A/G cg22176566 chr1:43424700 SLC2A1 -0.45 -6.0 -0.31 5.06e-9 Red cell distribution width; LUSC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6674176 0.542 rs803675 chr1:44353237 G/A cg15962314 chr1:44399869 ARTN 0.26 5.88 0.31 9.74e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2046867 0.818 rs62249874 chr3:72911202 G/C cg25664220 chr3:72788482 NA -0.62 -10.56 -0.5 1.07e-22 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg03188948 chr7:1209495 NA 0.65 6.9 0.35 2.56e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg03909863 chr11:638404 DRD4 -0.4 -5.86 -0.31 1.13e-8 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg05340658 chr4:99064831 C4orf37 0.65 11.09 0.52 1.58e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs11971779 0.838 rs4728468 chr7:139122978 G/A cg07862535 chr7:139043722 LUC7L2 0.7 8.49 0.42 6.64e-16 Diisocyanate-induced asthma; LUSC cis rs67696533 0.540 rs2889678 chr20:31189993 C/T cg13636640 chr20:31349939 DNMT3B -0.41 -5.92 -0.31 8.15e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs763014 0.966 rs15564 chr16:677854 G/T cg07343612 chr16:622815 PIGQ -0.71 -12.05 -0.55 5.25e-28 Height; LUSC cis rs1160297 0.609 rs10208858 chr2:53094982 G/A cg07782112 chr2:53107842 NA 0.4 6.7 0.34 8.8e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs240764 0.578 rs723743 chr6:101237504 T/C cg09795085 chr6:101329169 ASCC3 0.44 6.27 0.32 1.13e-9 Neuroticism; LUSC cis rs950776 0.518 rs12902493 chr15:78819275 C/G cg22563815 chr15:78856949 CHRNA5 0.25 6.13 0.32 2.5e-9 Sudden cardiac arrest; LUSC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.16 0.49 2.64e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00251250 chr1:234746546 IRF2BP2 -0.4 -6.0 -0.31 5.21e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7267979 1.000 rs2500448 chr20:25404027 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.37 -0.69 1.32e-48 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10761482 0.859 rs2199210 chr10:62094752 T/G cg18175470 chr10:62150864 ANK3 -0.45 -6.71 -0.34 8.5e-11 Schizophrenia; LUSC trans rs617791 0.508 rs10896074 chr11:65776304 C/T cg17712092 chr4:129076599 LARP1B -0.71 -9.97 -0.48 1.18e-20 Breast cancer; LUSC cis rs8133932 0.555 rs374331 chr21:47338218 A/G cg14185626 chr21:47401492 COL6A1 -0.44 -5.68 -0.3 2.93e-8 Schizophrenia; LUSC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg22823121 chr1:150693482 HORMAD1 0.53 7.95 0.4 2.9e-14 Melanoma; LUSC cis rs7937682 0.889 rs10789844 chr11:111579109 A/T cg22437258 chr11:111473054 SIK2 0.5 6.91 0.35 2.49e-11 Primary sclerosing cholangitis; LUSC cis rs16867335 1.000 rs2113786 chr2:181483250 C/T cg23363182 chr2:181467187 NA -0.48 -6.2 -0.32 1.66e-9 Survival in rectal cancer; LUSC cis rs425277 1.000 rs55826501 chr1:2059143 G/A cg24578937 chr1:2090814 PRKCZ 0.57 12.75 0.57 1.28e-30 Height; LUSC cis rs3809566 0.637 rs8026047 chr15:63323347 C/G cg05507819 chr15:63340323 TPM1 -0.47 -5.88 -0.31 9.78e-9 Platelet count; LUSC cis rs929596 0.561 rs11891311 chr2:234639310 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.54 9.07 0.44 1.04e-17 Total bilirubin levels in HIV-1 infection; LUSC cis rs6840360 0.571 rs7692700 chr4:152552797 C/T cg22705602 chr4:152727874 NA -0.31 -6.14 -0.32 2.34e-9 Intelligence (multi-trait analysis); LUSC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg16447950 chr5:562315 NA -0.58 -7.3 -0.37 2.1e-12 Obesity-related traits; LUSC cis rs921968 0.643 rs585859 chr2:219383121 C/T cg02176678 chr2:219576539 TTLL4 0.61 11.13 0.52 1.08e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs2219968 1.000 rs13248763 chr8:78975616 G/A cg00738934 chr8:78996279 NA 0.35 6.23 0.32 1.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg14159672 chr1:205819179 PM20D1 0.96 18.87 0.72 1.48e-54 Menarche (age at onset); LUSC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg11245181 chr6:149772854 ZC3H12D -0.3 -6.57 -0.34 1.91e-10 Dupuytren's disease; LUSC cis rs2274273 0.840 rs1045002 chr14:55818517 T/A cg04306507 chr14:55594613 LGALS3 0.53 11.64 0.54 1.66e-26 Protein biomarker; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg04166393 chr7:2884313 GNA12 0.48 6.31 0.33 8.74e-10 Height; LUSC cis rs7786808 0.608 rs7784758 chr7:158214386 A/G cg01191920 chr7:158217561 PTPRN2 -0.44 -9.08 -0.44 9.67e-18 Obesity-related traits; LUSC cis rs7927592 0.513 rs630225 chr11:68194611 A/C cg01657329 chr11:68192670 LRP5 -0.48 -7.43 -0.38 9.37e-13 Total body bone mineral density; LUSC cis rs10740039 0.883 rs10994468 chr10:62426291 A/G cg18175470 chr10:62150864 ANK3 -0.47 -7.09 -0.36 8.08e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7208859 0.623 rs9890558 chr17:29110355 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.26e-9 Developmental language disorder (linguistic errors); LUSC trans rs17105932 1.000 rs10890582 chr11:106631807 G/T cg24932660 chr1:27709575 CD164L2 0.65 5.98 0.31 5.76e-9 Anxiety disorder; LUSC cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg05043794 chr9:111880884 C9orf5 -0.33 -6.7 -0.34 9.06e-11 Menarche (age at onset); LUSC cis rs8060686 0.623 rs28700885 chr16:68154544 A/G cg09835421 chr16:68378352 PRMT7 -0.44 -5.78 -0.3 1.74e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg11764359 chr7:65958608 NA -0.68 -10.7 -0.51 3.74e-23 Aortic root size; LUSC cis rs11250464 0.736 rs5015512 chr10:1411923 T/C cg08668359 chr10:1443807 ADARB2 0.41 6.15 0.32 2.16e-9 Radiation response; LUSC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg06618935 chr21:46677482 NA -0.37 -7.33 -0.37 1.75e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg19318889 chr4:1322082 MAEA 0.39 6.36 0.33 6.46e-10 Obesity-related traits; LUSC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg13939156 chr17:80058883 NA 0.34 6.55 0.34 2.14e-10 Life satisfaction; LUSC cis rs929596 0.564 rs2741034 chr2:234548814 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -6.11 -0.32 2.81e-9 Total bilirubin levels in HIV-1 infection; LUSC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg14784868 chr12:69753453 YEATS4 0.62 8.7 0.43 1.55e-16 Cerebrospinal fluid biomarker levels; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg16325326 chr1:53192061 ZYG11B 0.78 14.03 0.61 1.72e-35 Monocyte count; LUSC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg02572448 chr1:8763403 RERE 0.42 6.15 0.32 2.15e-9 Mosquito bite size; LUSC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.86 0.35 3.37e-11 Intelligence (multi-trait analysis); LUSC cis rs3849570 0.695 rs9830445 chr3:81508063 T/G cg07356753 chr3:81810745 GBE1 0.46 6.07 0.32 3.47e-9 Waist circumference;Body mass index; LUSC cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg24812749 chr6:127587940 RNF146 0.7 9.92 0.48 1.75e-20 Breast cancer; LUSC trans rs34421088 0.560 rs2248316 chr8:11397073 A/C cg06636001 chr8:8085503 FLJ10661 -0.59 -9.16 -0.45 5.26e-18 Neuroticism; LUSC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg13607699 chr17:42295918 UBTF -0.4 -5.77 -0.3 1.77e-8 Total body bone mineral density; LUSC cis rs10489202 0.955 rs17557162 chr1:167985950 A/T cg24449463 chr1:168025552 DCAF6 0.59 7.64 0.39 2.26e-13 Schizophrenia; LUSC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.0 -0.36 1.45e-11 Blood metabolite levels; LUSC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg14784868 chr12:69753453 YEATS4 0.82 14.02 0.61 2.03e-35 Blood protein levels; LUSC cis rs611744 0.625 rs4735055 chr8:109286642 G/A cg18478394 chr8:109455254 TTC35 0.45 6.8 0.35 4.91e-11 Dupuytren's disease; LUSC cis rs7106204 1.000 rs4622259 chr11:24215789 A/G ch.11.24196551F chr11:24239977 NA 0.99 9.62 0.47 1.71e-19 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1413885 0.516 rs3818449 chr1:65844963 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.51 7.46 0.38 7.62e-13 Anticoagulant levels; LUSC cis rs4319547 0.656 rs28730465 chr12:122863864 A/C cg23029597 chr12:123009494 RSRC2 0.75 9.5 0.46 4.15e-19 Body mass index; LUSC cis rs9653442 0.564 rs7601892 chr2:100789490 G/A cg07810366 chr2:100720526 AFF3 -0.43 -7.28 -0.37 2.43e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9527 0.590 rs7920868 chr10:104795409 C/T cg05855489 chr10:104503620 C10orf26 0.53 8.12 0.41 9.19e-15 Arsenic metabolism; LUSC cis rs722599 0.748 rs741096 chr14:75351487 A/G cg06637938 chr14:75390232 RPS6KL1 -0.42 -6.15 -0.32 2.18e-9 IgG glycosylation; LUSC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg18402987 chr7:1209562 NA 0.62 7.18 0.37 4.62e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35079168 0.923 rs11103473 chr9:137287629 A/T cg13941235 chr9:137270186 RXRA 0.33 5.8 0.3 1.53e-8 Intelligence; LUSC cis rs8062405 0.965 rs8049439 chr16:28837515 A/G cg09754948 chr16:28834200 ATXN2L 0.4 5.94 0.31 7.11e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg16339924 chr4:17578868 LAP3 -0.55 -7.95 -0.4 2.97e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg03188948 chr7:1209495 NA 0.57 6.14 0.32 2.37e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7572644 0.766 rs13004096 chr2:28087205 C/T cg27432699 chr2:27873401 GPN1 0.52 6.47 0.33 3.5e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.48 0.5 2.17e-22 Schizophrenia; LUSC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg15145296 chr3:125709740 NA -0.59 -6.67 -0.34 1.06e-10 Blood pressure (smoking interaction); LUSC trans rs853679 0.517 rs3757187 chr6:28107654 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.1 -0.32 2.97e-9 Depression; LUSC cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.56 0.5 1.09e-22 Hip circumference adjusted for BMI; LUSC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg20503657 chr10:835505 NA 1.21 16.25 0.66 3.52e-44 Eosinophil percentage of granulocytes; LUSC cis rs4746818 0.793 rs2008541 chr10:70860599 A/G cg11621586 chr10:70884670 VPS26A 0.9 8.95 0.44 2.45e-17 Left atrial antero-posterior diameter; LUSC cis rs524023 1.000 rs3825018 chr11:64358809 G/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.1 -0.48 4.3e-21 Urate levels in obese individuals; LUSC trans rs6951245 0.872 rs76161580 chr7:1100307 G/T cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7584330 0.666 rs60671275 chr2:238374318 C/A cg14458575 chr2:238380390 NA 0.87 15.13 0.64 9.15e-40 Prostate cancer; LUSC cis rs75229567 0.717 rs74527680 chr12:70235392 A/G cg10114359 chr12:70132523 RAB3IP 1.34 11.2 0.52 6.25e-25 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16116313 chr12:122255002 SETD1B 0.49 6.14 0.32 2.41e-9 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg07936489 chr17:37558343 FBXL20 -0.72 -9.91 -0.48 1.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.9 0.35 2.56e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.21 -0.49 1.83e-21 Gut microbiome composition (summer); LUSC cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg01849466 chr14:104193079 ZFYVE21 -0.55 -7.91 -0.4 3.74e-14 Reticulocyte count; LUSC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg03264133 chr6:25882463 NA -0.45 -7.32 -0.37 1.83e-12 Intelligence (multi-trait analysis); LUSC cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg27446573 chr6:127587934 RNF146 0.92 15.35 0.64 1.35e-40 Breast cancer; LUSC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg09034736 chr1:150693464 HORMAD1 -0.4 -5.73 -0.3 2.29e-8 Tonsillectomy; LUSC cis rs7119 0.604 rs2667783 chr15:77862529 G/A cg27398640 chr15:77910606 LINGO1 0.36 7.96 0.4 2.63e-14 Type 2 diabetes; LUSC cis rs17095355 1.000 rs55683820 chr10:111665376 G/A cg00817464 chr10:111662876 XPNPEP1 -0.64 -7.47 -0.38 6.94e-13 Biliary atresia; LUSC cis rs7074356 0.831 rs12764048 chr10:82148963 A/G cg05935833 chr10:81318306 SFTPA2 -0.43 -5.67 -0.3 3.14e-8 Borderline personality disorder; LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg05717871 chr11:638507 DRD4 -0.34 -5.9 -0.31 8.74e-9 Systemic lupus erythematosus; LUSC cis rs1355223 0.506 rs7131272 chr11:34869548 A/G cg11058730 chr11:34937778 PDHX;APIP 0.46 6.64 0.34 1.27e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs362296 0.698 rs362266 chr4:3259632 C/G cg14583973 chr4:3374767 RGS12 -0.3 -5.87 -0.31 1.05e-8 Parental longevity (mother's age at death); LUSC trans rs1493916 0.870 rs8083723 chr18:31384398 C/T cg27147174 chr7:100797783 AP1S1 -0.65 -10.59 -0.5 8.47e-23 Life satisfaction; LUSC cis rs1044826 1.000 rs9289576 chr3:139200326 G/A cg00490450 chr3:139108681 COPB2 0.51 6.74 0.35 6.96e-11 Obesity-related traits; LUSC cis rs2354432 0.882 rs11576360 chr1:146740576 G/A cg25205988 chr1:146714368 CHD1L 1.1 14.45 0.62 4.26e-37 Mitochondrial DNA levels; LUSC trans rs6601327 0.606 rs4841204 chr8:9583407 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.49 -0.33 3.09e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.36 0.53 1.66e-25 Menopause (age at onset); LUSC cis rs804280 0.518 rs34266352 chr8:11791462 G/A cg21775007 chr8:11205619 TDH 0.46 6.55 0.34 2.18e-10 Myopia (pathological); LUSC cis rs2832077 0.506 rs2832093 chr21:30164855 C/T cg08807101 chr21:30365312 RNF160 -0.5 -6.75 -0.35 6.38e-11 Cognitive test performance; LUSC cis rs8017423 0.934 rs2401874 chr14:90682467 C/T cg04374321 chr14:90722782 PSMC1 0.7 11.12 0.52 1.19e-24 Mortality in heart failure; LUSC cis rs208515 0.525 rs10944863 chr6:66676238 C/T cg07460842 chr6:66804631 NA 1.01 13.91 0.61 4.95e-35 Exhaled nitric oxide levels; LUSC cis rs400736 0.729 rs1546846 chr1:8004259 C/T cg25007680 chr1:8021821 PARK7 -0.49 -7.22 -0.37 3.58e-12 Response to antidepressants and depression; LUSC cis rs7903847 0.642 rs10882913 chr10:99141845 C/T cg08345082 chr10:99160200 RRP12 -0.36 -7.28 -0.37 2.45e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg04850211 chr1:228464232 OBSCN 0.39 7.31 0.37 2.02e-12 Diastolic blood pressure; LUSC trans rs656319 0.580 rs13272793 chr8:10002027 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.34 -0.33 7.38e-10 Myopia (pathological); LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.07 -0.32 3.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg23758822 chr17:41437982 NA 1.04 19.97 0.74 6.31e-59 Menopause (age at onset); LUSC cis rs12594515 1.000 rs8038058 chr15:45990272 C/T cg19682013 chr15:45996608 NA 0.39 5.94 0.31 7.33e-9 Waist circumference;Weight; LUSC trans rs877282 0.853 rs10904544 chr10:756966 A/G cg22713356 chr15:30763199 NA 1.02 13.43 0.59 3.55e-33 Uric acid levels; LUSC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg27427491 chr17:78079615 GAA -0.36 -6.94 -0.36 2.02e-11 Yeast infection; LUSC cis rs8062405 0.824 rs62034326 chr16:28539293 A/G cg16576597 chr16:28551801 NUPR1 0.29 5.75 0.3 2.01e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6541297 1.000 rs2352723 chr1:230291868 C/T cg05784532 chr1:230284198 GALNT2 -0.6 -8.48 -0.42 7.46e-16 Coronary artery disease; LUSC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg05425664 chr17:57184151 TRIM37 -0.58 -8.86 -0.44 4.84e-17 Intelligence (multi-trait analysis); LUSC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg27589368 chr17:43923255 LOC100128977;IMP5 -0.27 -5.9 -0.31 9.02e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg00102166 chr1:43425337 SLC2A1 -0.53 -7.68 -0.39 1.73e-13 Monocyte count; LUSC cis rs826838 0.651 rs1843892 chr12:38616965 A/G cg26384229 chr12:38710491 ALG10B 0.77 12.06 0.55 4.9e-28 Heart rate; LUSC cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg06022373 chr22:39101656 GTPBP1 0.74 11.57 0.54 2.83e-26 Menopause (age at onset); LUSC trans rs61931739 0.649 rs815044 chr12:33722209 A/G cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs7589342 0.895 rs11901644 chr2:106432113 T/G cg16077055 chr2:106428750 NCK2 0.39 7.3 0.37 2.06e-12 Addiction; LUSC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg03563238 chr19:33554763 RHPN2 -0.33 -5.76 -0.3 1.9e-8 Colorectal cancer; LUSC trans rs10506458 1.000 rs73128779 chr12:63441852 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -15.62 -0.65 1.1e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg09998033 chr7:158218633 PTPRN2 -0.52 -8.5 -0.42 6.41e-16 Obesity-related traits; LUSC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg01411255 chr17:61851458 DDX42;CCDC47 1.06 22.39 0.77 1.82e-68 Height; LUSC cis rs13040088 0.935 rs3787513 chr20:61573736 G/A cg23096297 chr20:61557774 DIDO1 0.81 10.59 0.5 8.83e-23 Menopause (age at onset); LUSC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg02269571 chr22:50332266 NA 0.59 8.74 0.43 1.17e-16 Schizophrenia; LUSC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg05802129 chr4:122689817 NA -0.36 -6.44 -0.33 4.17e-10 Type 2 diabetes; LUSC cis rs7212590 0.748 rs8074176 chr17:57861995 G/A cg10252138 chr17:58120427 NA -0.72 -6.96 -0.36 1.76e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC trans rs853679 0.517 rs9348796 chr6:28126202 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.19e-9 Depression; LUSC cis rs4268898 0.662 rs72793208 chr2:24510284 C/T cg06627628 chr2:24431161 ITSN2 -0.86 -12.9 -0.58 3.55e-31 Asthma; LUSC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg09359103 chr1:154839909 KCNN3 0.68 15.83 0.65 1.75e-42 Prostate cancer; LUSC cis rs7089973 0.604 rs17095662 chr10:116596071 A/C cg03647239 chr10:116582469 FAM160B1 0.44 7.01 0.36 1.32e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4642101 0.640 rs12629398 chr3:12826799 A/G cg05775895 chr3:12838266 CAND2 0.61 10.8 0.51 1.63e-23 QRS complex (12-leadsum); LUSC cis rs1371867 0.817 rs7846076 chr8:101327629 A/G cg00191853 chr8:101177733 SPAG1 -0.38 -6.22 -0.32 1.48e-9 Atrioventricular conduction; LUSC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 11.19 0.52 6.83e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs5769707 0.642 rs135880 chr22:50018654 T/A cg05373962 chr22:49881684 NA -0.39 -8.64 -0.43 2.4e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.87 0.31 1.06e-8 Life satisfaction; LUSC cis rs2070433 1.000 rs2839302 chr21:47952364 G/A cg12379764 chr21:47803548 PCNT 0.79 10.25 0.49 1.26e-21 Lymphocyte counts; LUSC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg22105103 chr4:187893119 NA 0.71 13.83 0.6 1.03e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs9464760 0.527 rs9476759 chr6:15158709 T/C cg15799072 chr6:15248335 JARID2 0.52 5.86 0.31 1.08e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10992471 0.528 rs7860786 chr9:95245473 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.35 -6.13 -0.32 2.43e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg11812906 chr14:75593930 NEK9 0.66 11.33 0.53 2.04e-25 Height; LUSC cis rs10193935 0.792 rs13423729 chr2:42492874 C/T cg27598129 chr2:42591480 NA -0.58 -7.94 -0.4 3.05e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6429082 0.846 rs2270538 chr1:235602404 G/A cg26050004 chr1:235667680 B3GALNT2 -0.62 -8.62 -0.43 2.68e-16 Adiposity; LUSC cis rs1577917 1.000 rs13199006 chr6:86608708 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -8.46 -0.42 8.49e-16 Lymphocyte counts; LUSC cis rs9457247 1.000 rs394522 chr6:167398071 A/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.74 -0.35 6.85e-11 Crohn's disease; LUSC cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg11266682 chr4:10021025 SLC2A9 0.58 10.7 0.51 3.69e-23 Bone mineral density; LUSC cis rs2455601 0.766 rs1109304 chr11:8955455 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -8.27 -0.41 3.12e-15 Schizophrenia; LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg11752832 chr7:134001865 SLC35B4 0.53 8.18 0.41 5.88e-15 Mean platelet volume; LUSC trans rs9929218 0.911 rs1075959 chr16:68832750 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.2 -0.52 6.2e-25 Colorectal cancer; LUSC cis rs10791323 0.569 rs1119851 chr11:133742842 T/C cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg11752832 chr7:134001865 SLC35B4 0.53 7.97 0.4 2.48e-14 Mean platelet volume; LUSC cis rs500891 0.574 rs12524862 chr6:84146655 C/T cg08257003 chr6:84140564 ME1 0.38 9.14 0.45 6.37e-18 Platelet-derived growth factor BB levels; LUSC cis rs2348418 0.966 rs7136139 chr12:28684020 T/A cg13890972 chr12:28721907 NA -0.34 -5.83 -0.3 1.28e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs1007190 0.764 rs4793153 chr17:42873792 T/C cg15406952 chr17:42872593 NA -0.59 -6.13 -0.32 2.45e-9 DNA methylation (variation); LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg26354017 chr1:205819088 PM20D1 0.95 19.76 0.73 4.32e-58 Menarche (age at onset); LUSC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg22166914 chr1:53195759 ZYG11B -0.71 -12.32 -0.56 5.33e-29 Monocyte count; LUSC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg04287289 chr16:89883240 FANCA 0.8 14.3 0.62 1.56e-36 Vitiligo; LUSC cis rs10992471 0.603 rs10118939 chr9:95293641 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -6.97 -0.36 1.72e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg23711669 chr6:146136114 FBXO30 0.7 12.24 0.56 1.03e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 0.752 rs55801864 chr2:23922325 C/T cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.4e-12 Lymphocyte counts; LUSC cis rs6700896 0.931 rs10443261 chr1:66129121 T/C cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.01e-10 Blood pressure (smoking interaction); LUSC cis rs908922 0.542 rs4845785 chr1:152510143 C/T cg20991723 chr1:152506922 NA 0.53 10.03 0.48 7.05e-21 Hair morphology; LUSC cis rs7264396 0.790 rs3787166 chr20:34229072 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.39 -0.42 1.36e-15 Total cholesterol levels; LUSC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg23719950 chr11:63933701 MACROD1 -0.62 -7.99 -0.4 2.15e-14 Mean platelet volume; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg03235119 chr5:176449645 ZNF346 -0.37 -6.53 -0.34 2.42e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs66887589 0.934 rs56843000 chr4:120516597 T/C cg24375607 chr4:120327624 NA -0.47 -7.25 -0.37 2.96e-12 Diastolic blood pressure; LUSC cis rs11642862 0.710 rs17849880 chr16:30999198 C/T cg02466173 chr16:30829666 NA -0.61 -6.47 -0.33 3.42e-10 Tonsillectomy; LUSC cis rs2455601 0.638 rs2742485 chr11:8986787 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -6.93 -0.35 2.23e-11 Schizophrenia; LUSC cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg26384229 chr12:38710491 ALG10B 0.89 14.35 0.62 9.97e-37 Bladder cancer; LUSC cis rs981844 1.000 rs2405430 chr4:154658391 A/G cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs477692 1.000 rs538969 chr10:131410608 C/T cg26102564 chr10:131424627 MGMT 0.45 7.03 0.36 1.2e-11 Response to temozolomide; LUSC cis rs7100689 0.622 rs10736344 chr10:82133955 T/C cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs9640161 0.783 rs2021871 chr7:150071156 T/C cg10018233 chr7:150070692 REPIN1 0.45 9.06 0.44 1.13e-17 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.99 -0.4 2.18e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs11642862 1.000 rs11645175 chr16:30803299 C/T cg02466173 chr16:30829666 NA -0.69 -7.33 -0.37 1.8e-12 Tonsillectomy; LUSC cis rs11190604 0.767 rs7085426 chr10:102163640 T/C cg07080220 chr10:102295463 HIF1AN 0.58 7.61 0.38 2.74e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9467711 1.000 rs9467704 chr6:26319486 A/G cg16898833 chr6:26189333 HIST1H4D -0.6 -5.7 -0.3 2.7e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18404041 chr3:52824283 ITIH1 -0.56 -10.88 -0.51 8.32e-24 Electroencephalogram traits; LUSC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg05738196 chr6:26577821 NA -0.52 -8.28 -0.41 2.94e-15 Schizophrenia; LUSC cis rs113835537 0.529 rs11227503 chr11:66275242 G/C cg24851651 chr11:66362959 CCS 0.54 8.03 0.4 1.66e-14 Airway imaging phenotypes; LUSC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs897984 0.683 rs72799316 chr16:30827205 A/G cg02466173 chr16:30829666 NA -0.68 -16.27 -0.66 3.13e-44 Dementia with Lewy bodies; LUSC cis rs896543 0.702 rs12692190 chr2:237496190 C/T cg25295825 chr2:237489920 CXCR7 0.5 6.12 0.32 2.56e-9 Alcohol dependence (age at onset); LUSC cis rs9467711 0.606 rs9348709 chr6:26360311 G/A cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg25251562 chr2:3704773 ALLC -0.48 -7.39 -0.38 1.15e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs73200209 0.744 rs17498480 chr12:116558916 A/T cg01776926 chr12:116560359 MED13L -0.47 -5.75 -0.3 2.04e-8 Total body bone mineral density; LUSC cis rs17014483 0.749 rs2860422 chr4:89644931 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.66 5.75 0.3 1.98e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg18230493 chr5:56204884 C5orf35 -0.68 -10.24 -0.49 1.44e-21 Coronary artery disease; LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg22903657 chr4:1355424 KIAA1530 0.37 6.27 0.32 1.14e-9 Obesity-related traits; LUSC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7582720 1.000 rs72932572 chr2:203859391 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 8.37 0.42 1.63e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs11098499 0.954 rs6849561 chr4:120409694 C/G cg25214090 chr10:38739885 LOC399744 -0.53 -7.53 -0.38 4.78e-13 Corneal astigmatism; LUSC cis rs12682352 0.535 rs12677550 chr8:8644322 A/G cg06636001 chr8:8085503 FLJ10661 -0.42 -5.95 -0.31 6.74e-9 Neuroticism; LUSC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs7264396 0.563 rs6060570 chr20:34291166 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.66 -0.43 2.08e-16 Total cholesterol levels; LUSC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.62 13.24 0.59 1.94e-32 Monocyte percentage of white cells; LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.42 0.38 9.54e-13 Alzheimer's disease; LUSC trans rs10435719 0.902 rs7459545 chr8:11804389 G/T cg06636001 chr8:8085503 FLJ10661 0.53 7.93 0.4 3.25e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs7845219 0.544 rs9643350 chr8:95917276 C/A cg13393036 chr8:95962371 TP53INP1 -0.31 -5.95 -0.31 6.78e-9 Type 2 diabetes; LUSC cis rs2274273 0.806 rs7146752 chr14:55738907 A/G cg04306507 chr14:55594613 LGALS3 0.57 13.34 0.59 7.9e-33 Protein biomarker; LUSC cis rs8077577 0.836 rs58441148 chr17:18106498 T/A cg16794390 chr17:18148240 FLII 0.41 5.88 0.31 9.85e-9 Obesity-related traits; LUSC cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg24642439 chr20:33292090 TP53INP2 -0.5 -7.58 -0.38 3.4e-13 Coronary artery disease; LUSC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg13531842 chr10:38383804 ZNF37A -0.45 -6.98 -0.36 1.57e-11 Extrinsic epigenetic age acceleration; LUSC cis rs9914988 0.725 rs66531973 chr17:27125993 G/T cg09479241 chr17:27052676 TLCD1 0.45 6.12 0.32 2.66e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs73206853 0.841 rs16940933 chr12:111102574 C/A cg12870014 chr12:110450643 ANKRD13A 0.71 7.16 0.36 5.01e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs13191362 0.573 rs9365499 chr6:163271833 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.55 7.71 0.39 1.43e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9400467 0.528 rs457492 chr6:111641850 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.36 -0.33 6.48e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs12681287 0.752 rs67615966 chr8:87255203 C/A cg27223183 chr8:87520930 FAM82B -0.45 -5.72 -0.3 2.33e-8 Caudate activity during reward; LUSC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11890956 chr21:40555474 PSMG1 1.04 21.37 0.76 1.82e-64 Cognitive function; LUSC cis rs9788682 0.748 rs667282 chr15:78863472 T/C cg24631222 chr15:78858424 CHRNA5 0.69 9.14 0.45 6.07e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg07936489 chr17:37558343 FBXL20 -0.71 -9.96 -0.48 1.21e-20 Glomerular filtration rate (creatinine); LUSC cis rs7538876 1.000 rs942457 chr1:17739586 G/A cg07965774 chr1:17746286 RCC2 0.31 5.76 0.3 1.96e-8 Basal cell carcinoma; LUSC cis rs11098499 0.863 rs10019674 chr4:120443489 C/T cg24375607 chr4:120327624 NA -0.76 -11.09 -0.52 1.5e-24 Corneal astigmatism; LUSC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg18512352 chr11:47633146 NA -0.48 -9.77 -0.47 5.36e-20 Subjective well-being; LUSC cis rs2404602 0.647 rs11072612 chr15:76960984 A/T cg23625390 chr15:77176239 SCAPER -0.64 -9.66 -0.47 1.24e-19 Blood metabolite levels; LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 11.24 0.52 4.57e-25 Alzheimer's disease; LUSC cis rs9581857 0.547 rs4612914 chr13:28049128 A/G cg22138327 chr13:27999177 GTF3A 0.75 8.21 0.41 4.91e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs9457247 0.602 rs9459854 chr6:167465882 C/T cg07741184 chr6:167504864 NA 0.49 8.62 0.43 2.75e-16 Crohn's disease; LUSC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg22875332 chr1:76189707 ACADM 0.83 13.06 0.58 9.2e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg06636001 chr8:8085503 FLJ10661 0.67 10.28 0.49 9.9700000000000009e-22 Neuroticism; LUSC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.43 -6.55 -0.34 2.21e-10 Schizophrenia; LUSC trans rs7937682 0.889 rs1789355 chr11:111499718 T/C cg18187862 chr3:45730750 SACM1L 0.55 7.05 0.36 1.03e-11 Primary sclerosing cholangitis; LUSC cis rs7772486 0.875 rs2814866 chr6:146339414 C/A cg13319975 chr6:146136371 FBXO30 -0.47 -7.08 -0.36 8.5e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs950169 0.541 rs10795 chr15:85177297 G/A cg12863693 chr15:85201151 NMB 0.37 7.72 0.39 1.34e-13 Schizophrenia; LUSC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg14668632 chr7:2872130 GNA12 -0.46 -6.54 -0.34 2.29e-10 Height; LUSC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg04844267 chr4:1394941 NA 0.32 6.31 0.33 9.05e-10 Obesity-related traits; LUSC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.64 0.34 1.28e-10 Obesity-related traits; LUSC cis rs9309473 0.632 rs6546825 chr2:73592253 G/C cg20560298 chr2:73613845 ALMS1 -0.54 -7.98 -0.4 2.33e-14 Metabolite levels; LUSC cis rs11252926 0.931 rs12355162 chr10:563472 G/A cg16386425 chr10:429943 DIP2C 0.39 5.73 0.3 2.26e-8 Psychosis in Alzheimer's disease; LUSC trans rs6951245 1.000 rs113146460 chr7:1105164 C/G cg13565492 chr6:43139072 SRF -0.62 -6.56 -0.34 2.09e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12220238 1.000 rs10824103 chr10:75949415 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.88 0.35 2.93e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9650315 0.929 rs5027176 chr8:57179749 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC cis rs2898290 0.622 rs4840567 chr8:11347625 A/G cg21775007 chr8:11205619 TDH -0.49 -7.49 -0.38 6.03e-13 Systolic blood pressure; LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs2249625 0.545 rs60835713 chr6:72880349 T/C cg18830697 chr6:72922368 RIMS1 0.37 7.42 0.38 9.84e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg12573674 chr2:1569213 NA -0.57 -8.08 -0.4 1.18e-14 IgG glycosylation; LUSC cis rs861020 0.630 rs628300 chr1:209998298 C/T cg05527609 chr1:210001259 C1orf107 0.68 9.69 0.47 1.02e-19 Orofacial clefts; LUSC cis rs859767 0.603 rs842359 chr2:135345568 G/C cg12500956 chr2:135428796 TMEM163 0.26 6.09 0.32 3.09e-9 Neuroticism; LUSC cis rs62103177 0.636 rs9958792 chr18:77627876 T/C cg20368463 chr18:77673604 PQLC1 -0.6 -6.06 -0.31 3.74e-9 Opioid sensitivity; LUSC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg18904891 chr8:8559673 CLDN23 -0.44 -6.7 -0.34 8.93e-11 Mood instability; LUSC cis rs11864453 0.647 rs10492814 chr16:72126514 G/A cg01557791 chr16:72042693 DHODH -0.46 -6.84 -0.35 3.81e-11 Fibrinogen levels; LUSC trans rs13011075 0.919 rs17601687 chr2:68615899 A/G cg14221825 chr19:46271408 SIX5 -0.46 -6.59 -0.34 1.75e-10 Mean corpuscular volume; LUSC cis rs13392177 0.660 rs12988046 chr2:219073804 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.39 -5.79 -0.3 1.58e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.62 0.62 8.89e-38 Platelet count; LUSC cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg08873628 chr1:175162347 KIAA0040 0.39 5.75 0.3 2.06e-8 Alcohol dependence; LUSC cis rs11077998 0.967 rs60488670 chr17:80522667 T/C cg10255544 chr17:80519551 FOXK2 0.36 5.8 0.3 1.56e-8 Reticulocyte fraction of red cells; LUSC trans rs9329221 0.537 rs2062332 chr8:9980024 G/A cg08975724 chr8:8085496 FLJ10661 0.42 6.01 0.31 4.91e-9 Neuroticism; LUSC cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg13010199 chr12:38710504 ALG10B 0.53 8.25 0.41 3.76e-15 Morning vs. evening chronotype; LUSC cis rs10504229 0.679 rs72649131 chr8:58054288 G/T cg08219700 chr8:58056026 NA 0.46 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); LUSC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg09509183 chr1:209979624 IRF6 0.44 5.95 0.31 6.69e-9 Cleft lip with or without cleft palate; LUSC cis rs9640161 0.658 rs60467296 chr7:150015471 G/A cg27494647 chr7:150038898 RARRES2 0.47 7.19 0.37 4.35e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs2274273 0.638 rs58269011 chr14:55684388 A/G cg04306507 chr14:55594613 LGALS3 0.48 9.55 0.46 2.91e-19 Protein biomarker; LUSC trans rs2262909 0.745 rs1989120 chr19:22205528 T/C cg05197062 chr11:11642011 GALNTL4 -0.5 -6.94 -0.36 2.08e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 0.966 rs2257705 chr20:25264664 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.49 0.75 5.16e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.05 -0.31 3.87e-9 Coronary artery disease; LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg18404041 chr3:52824283 ITIH1 -0.62 -12.32 -0.56 5.06e-29 Bipolar disorder; LUSC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg00074818 chr8:8560427 CLDN23 0.59 9.72 0.47 8.05e-20 Obesity-related traits; LUSC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg18099408 chr3:52552593 STAB1 0.4 6.63 0.34 1.38e-10 Bipolar disorder; LUSC cis rs477692 1.000 rs506274 chr10:131409392 T/A cg26102564 chr10:131424627 MGMT 0.45 7.15 0.36 5.61e-12 Response to temozolomide; LUSC cis rs6840360 0.615 rs72728171 chr4:152469372 C/A cg22705602 chr4:152727874 NA -0.32 -6.47 -0.33 3.41e-10 Intelligence (multi-trait analysis); LUSC cis rs6580649 0.941 rs4760677 chr12:48449163 C/T cg24011408 chr12:48396354 COL2A1 -0.46 -6.17 -0.32 1.95e-9 Lung cancer; LUSC cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.21 0.37 3.66e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs557514 1.000 rs557514 chr1:182404684 A/G cg26135716 chr1:182360902 GLUL 0.5 7.31 0.37 2e-12 Common carotid intima-media thickness; LUSC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg23172400 chr8:95962367 TP53INP1 -0.4 -8.09 -0.4 1.12e-14 Type 2 diabetes; LUSC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.44 6.45 0.33 3.9e-10 Alzheimer's disease (late onset); LUSC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg09509183 chr1:209979624 IRF6 0.49 5.75 0.3 2.05e-8 Cleft lip with or without cleft palate; LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs2072499 0.966 rs1060604 chr1:156184268 T/C cg24450063 chr1:156163899 SLC25A44 1.15 23.13 0.78 2.56e-71 Testicular germ cell tumor; LUSC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.63 7.85 0.39 5.6e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs2070488 0.699 rs13078966 chr3:38517914 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 12.35 0.56 4.15e-29 Electrocardiographic conduction measures; LUSC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg09640425 chr7:158790006 NA -0.53 -8.56 -0.42 4.21e-16 Facial morphology (factor 20); LUSC cis rs804280 0.509 rs12719915 chr8:11786255 A/G cg21775007 chr8:11205619 TDH -0.45 -6.47 -0.33 3.44e-10 Myopia (pathological); LUSC cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg22117172 chr7:91764530 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs881375 0.967 rs2416805 chr9:123676482 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.88 0.35 3.04e-11 Rheumatoid arthritis; LUSC cis rs951366 0.576 rs1832775 chr1:205734032 C/T cg14893161 chr1:205819251 PM20D1 -0.47 -6.39 -0.33 5.57e-10 Menarche (age at onset); LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 12.93 0.58 2.65e-31 Platelet count; LUSC cis rs7107174 0.901 rs2450137 chr11:77925233 C/G cg02023728 chr11:77925099 USP35 0.54 7.71 0.39 1.41e-13 Testicular germ cell tumor; LUSC cis rs12971120 0.838 rs2241510 chr18:72180739 G/A cg25817165 chr18:72167213 CNDP2 -0.72 -8.39 -0.42 1.37e-15 Refractive error; LUSC cis rs7568458 0.527 rs35416445 chr2:85773659 A/G cg23752985 chr2:85803571 VAMP8 0.33 6.36 0.33 6.62e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10208940 0.920 rs35002937 chr2:68753240 T/A cg12452813 chr2:68675892 NA 0.56 5.81 0.3 1.45e-8 Urate levels in lean individuals; LUSC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.54 0.34 2.27e-10 Tonsillectomy; LUSC trans rs11764590 0.950 rs55683212 chr7:2078855 G/C cg10840412 chr1:235813424 GNG4 0.55 7.14 0.36 5.85e-12 Neuroticism; LUSC cis rs12478296 0.792 rs6740738 chr2:243007368 A/C cg06360820 chr2:242988706 NA -0.72 -8.83 -0.43 6.1e-17 Obesity-related traits; LUSC cis rs7707921 0.767 rs862242 chr5:81587566 C/T cg15871215 chr5:81402204 ATG10 -0.45 -7.04 -0.36 1.1e-11 Breast cancer; LUSC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.46e-11 Tonsillectomy; LUSC cis rs6967385 0.560 rs10254029 chr7:12343148 G/C cg06484146 chr7:12443880 VWDE 0.45 6.71 0.34 8.1e-11 Response to taxane treatment (placlitaxel); LUSC cis rs11958404 1.000 rs72816538 chr5:157414303 A/G cg05962755 chr5:157440814 NA 0.49 6.13 0.32 2.44e-9 IgG glycosylation; LUSC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg17211192 chr8:82754475 SNX16 -0.58 -8.19 -0.41 5.42e-15 Diastolic blood pressure; LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg22875332 chr1:76189707 ACADM 0.78 11.36 0.53 1.73e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg18404041 chr3:52824283 ITIH1 -0.5 -9.53 -0.46 3.33e-19 Bipolar disorder; LUSC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg21862992 chr11:68658383 NA 0.51 7.99 0.4 2.25e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs877282 0.891 rs12357999 chr10:796468 A/C cg22713356 chr15:30763199 NA 1.09 15.78 0.65 2.59e-42 Uric acid levels; LUSC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs34779708 0.897 rs7897827 chr10:35386237 C/T cg03585969 chr10:35415529 CREM 0.62 9.23 0.45 3.12e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17270561 0.609 rs1317817 chr6:25765377 G/A cg17691542 chr6:26056736 HIST1H1C 0.57 7.8 0.39 7.92e-14 Iron status biomarkers; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg11494091 chr17:61959527 GH2 0.64 13.57 0.6 1e-33 Prudent dietary pattern; LUSC cis rs7607369 0.648 rs7582193 chr2:219652532 T/C cg02176678 chr2:219576539 TTLL4 -0.67 -13.08 -0.58 7.21e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs8017423 0.935 rs7160304 chr14:90752908 G/T cg04374321 chr14:90722782 PSMC1 0.69 10.65 0.5 5.28e-23 Mortality in heart failure; LUSC cis rs10927875 0.864 rs1976402 chr1:16143779 G/A cg22431228 chr1:16359049 CLCNKA 0.4 7.39 0.37 1.18e-12 Dilated cardiomyopathy; LUSC cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg06092702 chr1:163392909 NA -0.46 -7.63 -0.39 2.47e-13 Motion sickness; LUSC cis rs17255340 0.539 rs1144185 chr6:84012619 A/G cg08257003 chr6:84140564 ME1 0.32 7.59 0.38 3.28e-13 Platelet-derived growth factor BB levels; LUSC trans rs7937682 0.924 rs7938360 chr11:111539875 A/G cg18187862 chr3:45730750 SACM1L 0.56 7.23 0.37 3.34e-12 Primary sclerosing cholangitis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21871407 chr14:50159882 KLHDC1 -0.42 -6.2 -0.32 1.71e-9 Electrocardiographic conduction measures; LUSC cis rs1034435 0.547 rs5768686 chr22:48899214 G/A cg05992904 chr22:48892994 FAM19A5 -0.37 -6.58 -0.34 1.82e-10 Late-onset Alzheimer's disease; LUSC cis rs193541 0.632 rs1903260 chr5:122135188 T/C cg19077854 chr5:122220652 SNX24 0.37 7.56 0.38 3.94e-13 Glucose homeostasis traits; LUSC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.62 -12.99 -0.58 1.64e-31 Monocyte percentage of white cells; LUSC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg00071950 chr4:10020882 SLC2A9 -0.53 -8.26 -0.41 3.41e-15 Bone mineral density; LUSC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg26314531 chr2:26401878 FAM59B -0.69 -9.5 -0.46 4.2e-19 Gut microbiome composition (summer); LUSC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg26818010 chr10:134567672 INPP5A -0.68 -9.95 -0.48 1.3e-20 Migraine; LUSC cis rs56804039 1.000 rs56804039 chr8:8381029 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -6.27 -0.32 1.12e-9 Cervical cancer; LUSC cis rs9388451 0.868 rs10457467 chr6:126045148 T/A cg10911889 chr6:126070802 HEY2 0.41 6.29 0.33 9.69e-10 Brugada syndrome; LUSC trans rs61931739 0.817 rs11053071 chr12:34201400 A/G cg24313572 chr1:56050060 NA -0.29 -6.04 -0.31 4.2e-9 Morning vs. evening chronotype; LUSC cis rs7647973 0.626 rs62262722 chr3:49769419 G/C cg03060546 chr3:49711283 APEH -0.62 -7.12 -0.36 6.76e-12 Menarche (age at onset); LUSC cis rs7903847 0.596 rs9787426 chr10:99155327 A/G cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg17366294 chr4:99064904 C4orf37 0.63 11.29 0.53 2.99e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs9788682 0.747 rs2568488 chr15:78736593 T/A cg06917634 chr15:78832804 PSMA4 0.49 5.99 0.31 5.35e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg03354898 chr7:1950403 MAD1L1 -0.33 -6.44 -0.33 4.28e-10 Bipolar disorder and schizophrenia; LUSC cis rs7615316 0.751 rs6772400 chr3:142152477 T/A cg16271453 chr3:142027066 XRN1 -0.43 -7.42 -0.38 9.9e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2425143 1.000 rs6060524 chr20:34221155 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.12 -0.32 2.56e-9 Blood protein levels; LUSC cis rs7804356 1.000 rs3801832 chr7:26852280 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.08 -0.32 3.23e-9 Type 1 diabetes; LUSC cis rs4654899 0.897 rs10916859 chr1:21087956 A/G cg01072550 chr1:21505969 NA -0.45 -6.7 -0.34 9.04e-11 Superior frontal gyrus grey matter volume; LUSC cis rs9341835 0.679 rs9344137 chr6:64156964 A/T cg03326410 chr6:64151739 NA -0.37 -5.98 -0.31 5.64e-9 Schizophrenia; LUSC cis rs11585357 0.843 rs72633805 chr1:17617471 A/T cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC cis rs921968 0.643 rs2278529 chr2:219502132 C/T cg02176678 chr2:219576539 TTLL4 0.56 10.41 0.49 3.65e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs2404602 0.698 rs12909656 chr15:76664378 A/T cg23625390 chr15:77176239 SCAPER -0.61 -9.56 -0.46 2.6e-19 Blood metabolite levels; LUSC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.54 0.38 4.59e-13 Cognitive function; LUSC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg02951883 chr7:2050386 MAD1L1 -0.48 -8.56 -0.42 4.26e-16 Bipolar disorder and schizophrenia; LUSC cis rs765787 0.530 rs10467979 chr15:45521270 G/A cg25801113 chr15:45476975 SHF 0.34 7.03 0.36 1.17e-11 Uric acid levels; LUSC cis rs1729951 0.514 rs75977 chr3:136700549 C/A cg12473912 chr3:136751656 NA 0.39 6.87 0.35 3.24e-11 Neuroticism; LUSC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg11812906 chr14:75593930 NEK9 0.67 11.64 0.54 1.61e-26 Height; LUSC cis rs4704187 0.687 rs7700965 chr5:74356857 T/C cg03227963 chr5:74354835 NA 0.32 6.96 0.36 1.77e-11 Response to amphetamines; LUSC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.92e-10 Life satisfaction; LUSC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg20283391 chr11:68216788 NA 0.54 8.02 0.4 1.82e-14 Total body bone mineral density; LUSC trans rs9467711 0.659 rs66941101 chr6:26530376 C/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.64 -0.34 1.3e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg21573476 chr21:45109991 RRP1B -0.43 -6.94 -0.36 2.04e-11 Mean corpuscular volume; LUSC cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg06627628 chr2:24431161 ITSN2 -0.59 -7.24 -0.37 3.06e-12 Lymphocyte counts; LUSC cis rs13315871 1.000 rs12330157 chr3:58364562 C/T cg12435725 chr3:58293450 RPP14 -0.72 -7.16 -0.36 5.13e-12 Cholesterol, total; LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg25072359 chr17:41440525 NA 0.65 9.22 0.45 3.32e-18 Menopause (age at onset); LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg22535103 chr8:58192502 C8orf71 -0.78 -8.35 -0.42 1.88e-15 Developmental language disorder (linguistic errors); LUSC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg07741184 chr6:167504864 NA -0.36 -6.59 -0.34 1.73e-10 Crohn's disease; LUSC trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -9.05 -0.44 1.25e-17 Neuroticism; LUSC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg26408565 chr15:76604113 ETFA -0.49 -7.82 -0.39 7.17e-14 Blood metabolite levels; LUSC cis rs7822232 1.000 rs7822232 chr8:145145687 A/C cg14631276 chr8:145163102 KIAA1875 -0.81 -7.18 -0.37 4.68e-12 Blood metabolite levels; LUSC cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.93 0.4 3.39e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs10203711 1.000 rs10203711 chr2:239553368 C/T cg14580085 chr2:239553406 NA 0.42 6.96 0.36 1.83e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 1.000 rs5751086 chr22:41768862 C/T cg03806693 chr22:41940476 POLR3H -0.66 -9.98 -0.48 1.07e-20 Vitiligo; LUSC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg18876405 chr7:65276391 NA 0.7 12.65 0.57 3.19e-30 Aortic root size; LUSC cis rs7615952 0.546 rs2922197 chr3:125322032 G/A cg05084668 chr3:125655381 ALG1L -0.46 -5.91 -0.31 8.44e-9 Blood pressure (smoking interaction); LUSC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg17971929 chr21:40555470 PSMG1 -0.82 -14.52 -0.62 2.23e-37 Cognitive function; LUSC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.01 -0.36 1.34e-11 Lung cancer; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg16606067 chr5:178977123 RUFY1 0.36 5.99 0.31 5.38e-9 Schizophrenia; LUSC cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg19717773 chr7:2847554 GNA12 0.37 6.68 0.34 1.01e-10 Height; LUSC cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg19812747 chr11:111475976 SIK2 -0.57 -8.47 -0.42 7.76e-16 Primary sclerosing cholangitis; LUSC cis rs12477438 0.765 rs6542846 chr2:99563654 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.53 -0.5 1.41e-22 Chronic sinus infection; LUSC cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg08807101 chr21:30365312 RNF160 0.63 10.34 0.49 6.26e-22 Pancreatic cancer; LUSC cis rs9549367 0.789 rs9549708 chr13:113891887 A/G cg00898013 chr13:113819073 PROZ -0.55 -7.86 -0.39 5.42e-14 Platelet distribution width; LUSC cis rs713477 0.967 rs12887653 chr14:55911030 T/A cg13175173 chr14:55914753 NA -0.32 -6.7 -0.34 8.86e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs1113500 0.799 rs1777459 chr1:108584999 G/C cg06207961 chr1:108661230 NA -0.37 -6.73 -0.35 7.57e-11 Growth-regulated protein alpha levels; LUSC cis rs9911578 0.730 rs55759249 chr17:57027135 A/G cg12560992 chr17:57184187 TRIM37 -0.75 -11.35 -0.53 1.86e-25 Intelligence (multi-trait analysis); LUSC cis rs6942756 0.955 rs9641849 chr7:128899238 C/T cg02491457 chr7:128862824 NA -0.52 -7.37 -0.37 1.38e-12 White matter hyperintensity burden; LUSC cis rs11098499 0.865 rs2389809 chr4:120377399 T/C cg09307838 chr4:120376055 NA 0.76 11.06 0.52 2.01e-24 Corneal astigmatism; LUSC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.9 0.35 2.56e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs4961252 0.545 rs1107258 chr8:142104071 G/A cg09914555 chr8:142094789 NA -0.47 -7.15 -0.36 5.62e-12 Isovolumetric relaxation time;Response to interferon beta therapy; LUSC cis rs7572644 0.713 rs12617171 chr2:28038799 C/T cg27432699 chr2:27873401 GPN1 0.57 6.96 0.36 1.82e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11992162 0.613 rs56094399 chr8:11797470 G/A cg21775007 chr8:11205619 TDH -0.44 -5.97 -0.31 6.09e-9 Monocyte count; LUSC cis rs2540226 0.844 rs1035139 chr2:39999315 G/A cg23576258 chr2:39999331 THUMPD2 0.34 5.73 0.3 2.24e-8 Personality dimensions; LUSC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.75 -9.66 -0.47 1.26e-19 Gut microbiome composition (summer); LUSC trans rs11098499 0.604 rs2389886 chr4:120570422 C/T cg25214090 chr10:38739885 LOC399744 0.5 7.2 0.37 4.1e-12 Corneal astigmatism; LUSC trans rs9291683 0.507 rs6845554 chr4:10013173 T/G cg26043149 chr18:55253948 FECH 0.48 7.2 0.37 4.05e-12 Bone mineral density; LUSC cis rs829883 0.664 rs829874 chr12:98840615 G/A cg25150519 chr12:98850993 NA 0.8 13.41 0.59 4.3e-33 Colorectal adenoma (advanced); LUSC cis rs10927875 0.619 rs1806991 chr1:16129441 T/C cg21385522 chr1:16154831 NA -0.61 -9.85 -0.47 2.99e-20 Dilated cardiomyopathy; LUSC cis rs3814231 0.531 rs11196446 chr10:115471016 A/C cg24846397 chr10:115438155 CASP7 -0.33 -5.75 -0.3 2.01e-8 Vitiligo; LUSC cis rs11105306 1 rs11105306 chr12:89897388 C/T cg00757033 chr12:89920650 WDR51B 0.6 10.4 0.49 4.04e-22 NT-proBNP levels in acute coronary syndrome; LUSC cis rs2290416 0.786 rs60401352 chr8:144673097 G/A cg08017634 chr8:144659831 NAPRT1 0.7 6.06 0.31 3.64e-9 Attention deficit hyperactivity disorder; LUSC cis rs754466 0.580 rs2579177 chr10:79529245 C/T cg17075019 chr10:79541650 NA -0.75 -11.09 -0.52 1.51e-24 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg14019146 chr3:50243930 SLC38A3 -0.37 -8.19 -0.41 5.67e-15 Body mass index; LUSC cis rs7903847 0.642 rs7078782 chr10:99168604 C/T cg20016023 chr10:99160130 RRP12 -0.3 -7.45 -0.38 7.84e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs6582630 0.555 rs11181053 chr12:38271364 T/C cg26384229 chr12:38710491 ALG10B -0.59 -9.02 -0.44 1.55e-17 Drug-induced liver injury (flucloxacillin); LUSC cis rs10789491 1.000 rs1440487 chr1:47167075 C/T cg15501359 chr1:47185051 KIAA0494 -0.82 -11.77 -0.54 5.26e-27 Response to hepatitis C treatment; LUSC cis rs62458065 1.000 rs6462363 chr7:32464759 T/G cg20159608 chr7:32802032 NA -0.57 -7.01 -0.36 1.34e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs1215050 0.904 rs165246 chr4:98688541 C/T cg05340658 chr4:99064831 C4orf37 0.41 6.5 0.34 2.86e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6500602 0.727 rs4786515 chr16:4578133 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.58 0.38 3.37e-13 Schizophrenia; LUSC trans rs7613875 0.578 rs2624822 chr3:50107219 T/C cg21659725 chr3:3221576 CRBN -0.52 -8.38 -0.42 1.5e-15 Body mass index; LUSC cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Bone mineral density; LUSC cis rs2599510 0.783 rs2038534 chr2:32659489 G/A cg02381751 chr2:32503542 YIPF4 0.4 5.82 0.3 1.41e-8 Interleukin-18 levels; LUSC cis rs9398803 0.713 rs9375447 chr6:126874091 A/G cg19875578 chr6:126661172 C6orf173 0.39 5.64 0.3 3.54e-8 Male-pattern baldness; LUSC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg13012494 chr21:47604986 C21orf56 0.42 6.3 0.33 9.41e-10 Testicular germ cell tumor; LUSC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg16928487 chr17:17741425 SREBF1 -0.43 -8.55 -0.42 4.5e-16 Total body bone mineral density; LUSC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg02018176 chr4:1364513 KIAA1530 0.55 9.94 0.48 1.46e-20 Longevity; LUSC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg11062466 chr8:58055876 NA 0.72 6.96 0.36 1.76e-11 Developmental language disorder (linguistic errors); LUSC cis rs9287719 0.934 rs10181806 chr2:10741141 A/G cg03983476 chr2:10830698 NOL10 -0.37 -5.71 -0.3 2.56e-8 Prostate cancer; LUSC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg03433033 chr1:76189801 ACADM 0.8 12.95 0.58 2.42e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs983392 0.709 rs4492839 chr11:59986399 T/A cg24026212 chr11:59952134 MS4A6A -0.35 -6.1 -0.32 2.9e-9 Alzheimer's disease (late onset); LUSC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs2392780 0.512 rs594076 chr8:128334966 G/C cg10195415 chr17:73887371 TRIM65 0.41 6.49 0.33 3.12e-10 Breast cancer (early onset); LUSC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg23172400 chr8:95962367 TP53INP1 -0.3 -6.11 -0.32 2.79e-9 Type 2 diabetes; LUSC cis rs7560272 0.538 rs13000788 chr2:73918312 C/T cg20560298 chr2:73613845 ALMS1 0.4 6.13 0.32 2.54e-9 Schizophrenia; LUSC cis rs11098499 0.955 rs1551 chr4:120158500 T/G cg09307838 chr4:120376055 NA 0.7 10.17 0.49 2.4e-21 Corneal astigmatism; LUSC cis rs12137294 0.866 rs896318 chr1:205205784 A/G cg00857998 chr1:205179979 DSTYK 0.4 5.77 0.3 1.77e-8 Red cell distribution width; LUSC cis rs9612 0.950 rs7256472 chr19:44246970 C/T cg08581076 chr19:44259116 C19orf61 0.53 6.57 0.34 1.88e-10 Exhaled nitric oxide output; LUSC cis rs61931739 0.517 rs1817760 chr12:34106060 A/G cg06521331 chr12:34319734 NA -0.47 -7.67 -0.39 1.95e-13 Morning vs. evening chronotype; LUSC cis rs250677 0.617 rs166106 chr5:148447061 T/C cg23229984 chr5:148520753 ABLIM3 0.42 6.25 0.32 1.27e-9 Breast cancer; LUSC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.51 0.5 1.63e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs79149102 0.737 rs12593975 chr15:75189591 G/A cg09165964 chr15:75287851 SCAMP5 -0.88 -6.55 -0.34 2.12e-10 Lung cancer; LUSC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg04414720 chr1:150670196 GOLPH3L 0.53 8.62 0.43 2.81e-16 Tonsillectomy; LUSC cis rs73206853 0.620 rs17682482 chr12:111154788 C/G cg12870014 chr12:110450643 ANKRD13A 0.68 6.54 0.34 2.36e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs983392 0.709 rs2081547 chr11:59989430 C/T cg24026212 chr11:59952134 MS4A6A -0.35 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); LUSC cis rs6445797 0.632 rs7626378 chr3:56602885 A/T cg13792233 chr3:56591045 CCDC66 0.4 5.67 0.3 3.09e-8 Gastritis; LUSC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg05340658 chr4:99064831 C4orf37 0.57 9.52 0.46 3.59e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg06022373 chr22:39101656 GTPBP1 -0.69 -10.52 -0.5 1.49e-22 Menopause (age at onset); LUSC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.73 0.39 1.26e-13 Bipolar disorder; LUSC cis rs1595825 0.945 rs1518369 chr2:198859183 C/T cg00982548 chr2:198649783 BOLL -0.56 -7.17 -0.37 4.94e-12 Ulcerative colitis; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg20607798 chr8:58055168 NA 0.55 5.83 0.3 1.28e-8 Developmental language disorder (linguistic errors); LUSC cis rs6005807 0.719 rs58049055 chr22:29007850 A/G cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs9467711 0.591 rs34791189 chr6:26035806 G/A cg16898833 chr6:26189333 HIST1H4D 0.62 5.84 0.3 1.24e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs79387448 0.638 rs116055209 chr2:103032189 C/T cg09003973 chr2:102972529 NA 0.98 10.18 0.49 2.25e-21 Gut microbiota (bacterial taxa); LUSC cis rs477895 1.000 rs41294396 chr11:64078581 G/A cg23719950 chr11:63933701 MACROD1 -0.6 -7.25 -0.37 2.89e-12 Mean platelet volume; LUSC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.68 -12.17 -0.55 1.82e-28 Personality dimensions; LUSC cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.53 0.38 4.76e-13 Colorectal cancer; LUSC cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg05283184 chr6:79620031 NA -0.57 -12.14 -0.55 2.43e-28 Intelligence (multi-trait analysis); LUSC cis rs6867032 0.695 rs3902820 chr5:2000330 T/A cg26168224 chr5:2018326 NA -0.75 -13.22 -0.59 2.21e-32 Gut microbiome composition (winter); LUSC cis rs1691799 0.899 rs1185244 chr12:66725160 C/T cg16791601 chr12:66731901 HELB -0.71 -12.37 -0.56 3.46e-29 White blood cell count (basophil); LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.01 0.31 4.91e-9 Menopause (age at onset); LUSC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg06634786 chr22:41940651 POLR3H -0.51 -5.98 -0.31 5.74e-9 Vitiligo; LUSC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.48 0.38 6.44e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg03916912 chr11:95522834 CEP57;FAM76B -0.78 -13.03 -0.58 1.17e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9790314 0.580 rs10936227 chr3:161043869 A/C cg03342759 chr3:160939853 NMD3 -0.41 -6.06 -0.31 3.59e-9 Morning vs. evening chronotype; LUSC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg00049323 chr5:472564 LOC25845 -0.43 -6.71 -0.34 8.18e-11 Cystic fibrosis severity; LUSC cis rs72781680 0.898 rs72786277 chr2:24062818 T/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg11905131 chr22:24372483 LOC391322 -0.49 -8.21 -0.41 4.73e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC trans rs12310956 0.532 rs6488186 chr12:33974122 G/A cg13010199 chr12:38710504 ALG10B 0.52 7.71 0.39 1.5e-13 Morning vs. evening chronotype; LUSC cis rs2625529 0.526 rs8040828 chr15:72492779 C/A cg16672083 chr15:72433130 SENP8 0.47 7.98 0.4 2.36e-14 Red blood cell count; LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg05025164 chr4:1340916 KIAA1530 0.51 7.63 0.39 2.56e-13 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21115516 chr19:9251333 ZNF317 0.49 7.19 0.37 4.35e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs17433780 0.857 rs12140979 chr1:89467242 C/G cg09516651 chr1:89888402 LOC400759 0.49 8.05 0.4 1.42e-14 Carotid intima media thickness; LUSC cis rs1577917 0.959 rs2816822 chr6:86658292 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.26 -0.32 1.18e-9 Response to antipsychotic treatment; LUSC cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg12219531 chr12:120966889 COQ5 0.59 8.06 0.4 1.34e-14 High light scatter reticulocyte count; LUSC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.74 -0.35 6.77e-11 Developmental language disorder (linguistic errors); LUSC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.84 0.44 5.52e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg17971929 chr21:40555470 PSMG1 -0.54 -7.76 -0.39 1.02e-13 Menarche (age at onset); LUSC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg03233332 chr7:66118400 NA 0.41 6.05 0.31 3.95e-9 Aortic root size; LUSC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg10523679 chr1:76189770 ACADM 0.83 13.64 0.6 5.67e-34 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs35110281 0.782 rs1454651 chr21:45012476 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.61 10.14 0.49 3.12e-21 Mean corpuscular volume; LUSC cis rs5758511 0.680 rs5758686 chr22:42655377 G/T cg00645731 chr22:42541494 CYP2D7P1 0.57 9.9 0.48 1.97e-20 Birth weight; LUSC cis rs9443189 0.570 rs485906 chr6:76300550 A/C cg01950844 chr6:76311363 SENP6 0.7 6.98 0.36 1.63e-11 Prostate cancer; LUSC cis rs7084921 0.608 rs4475856 chr10:101833339 G/T cg02250046 chr10:101825185 CPN1 -0.35 -6.46 -0.33 3.66e-10 Bone mineral density; LUSC cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg13535736 chr9:111863775 C9orf5 -0.4 -6.66 -0.34 1.12e-10 Menarche (age at onset); LUSC cis rs2742417 1.000 rs2742417 chr3:45731451 C/T cg04837898 chr3:45731254 SACM1L -0.35 -5.82 -0.3 1.41e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg12386194 chr3:101231763 SENP7 0.64 8.96 0.44 2.36e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs6733011 0.530 rs7608889 chr2:99481350 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.81 -0.35 4.62e-11 Bipolar disorder; LUSC cis rs11031096 0.655 rs12275634 chr11:4211754 T/G cg18678763 chr11:4115507 RRM1 -0.41 -5.73 -0.3 2.29e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs16854884 0.739 rs56196484 chr3:143786160 G/T cg06585982 chr3:143692056 C3orf58 0.49 7.47 0.38 7.24e-13 Economic and political preferences (feminism/equality); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07005090 chr11:59522827 STX3 -0.4 -6.0 -0.31 5.14e-9 Electrocardiographic conduction measures; LUSC cis rs7681440 0.904 rs6816469 chr4:90772885 G/C cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.26e-8 Dementia with Lewy bodies; LUSC cis rs7100689 0.577 rs9421464 chr10:82043426 C/T cg01528321 chr10:82214614 TSPAN14 0.91 14.23 0.61 2.92e-36 Post bronchodilator FEV1; LUSC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg10253484 chr15:75165896 SCAMP2 -0.5 -7.59 -0.38 3.15e-13 Breast cancer; LUSC cis rs7241530 0.662 rs71362787 chr18:75907482 G/A cg14642773 chr18:75888474 NA 0.38 5.72 0.3 2.41e-8 Educational attainment (years of education); LUSC cis rs6121246 0.697 rs6088856 chr20:30226543 C/G cg13852791 chr20:30311386 BCL2L1 0.84 10.24 0.49 1.43e-21 Mean corpuscular hemoglobin; LUSC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.909 rs9994810 chr4:120381590 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.44 0.33 4.04e-10 Corneal astigmatism; LUSC trans rs7829975 0.659 rs4382480 chr8:8721473 C/T cg21775007 chr8:11205619 TDH 0.47 6.89 0.35 2.71e-11 Mood instability; LUSC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg03684893 chr10:554711 DIP2C -0.38 -6.83 -0.35 4.09e-11 Psychosis in Alzheimer's disease; LUSC cis rs1005224 0.782 rs34882722 chr14:76153896 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.63 -8.53 -0.42 5.35e-16 Large artery stroke; LUSC cis rs11155671 0.530 rs7768665 chr6:150208024 G/A cg13206674 chr6:150067644 NUP43 0.43 6.56 0.34 2.01e-10 Testicular germ cell tumor; LUSC cis rs477692 1.000 rs554792 chr10:131423181 A/G cg11019008 chr10:131425282 MGMT 0.39 5.84 0.3 1.26e-8 Response to temozolomide; LUSC cis rs7267979 0.899 rs6115213 chr20:25550372 G/A cg03522245 chr20:25566470 NINL 0.36 5.8 0.3 1.54e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs950169 0.881 rs4081123 chr15:84956235 A/G cg17173187 chr15:85201210 NMB 0.37 6.4 0.33 5.31e-10 Schizophrenia; LUSC cis rs9549260 0.755 rs12585875 chr13:41199531 A/G cg21288729 chr13:41239152 FOXO1 0.6 9.21 0.45 3.75e-18 Red blood cell count; LUSC cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.92 0.4 3.59e-14 Colorectal cancer; LUSC cis rs4722585 0.533 rs12334205 chr7:26202490 G/A cg07876897 chr7:26191696 NFE2L3 0.46 6.75 0.35 6.4e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg11057378 chr10:81107060 PPIF 0.34 5.95 0.31 6.77e-9 Height; LUSC cis rs1697139 0.583 rs1428475 chr5:66543954 G/T cg11553311 chr5:66541588 NA 0.33 6.24 0.32 1.33e-9 Breast cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00408597 chr11:9685941 SWAP70 -0.51 -6.06 -0.31 3.58e-9 Bipolar disorder and schizophrenia; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg26678313 chr12:57521867 LRP1 0.41 6.19 0.32 1.79e-9 Metabolite levels (Pyroglutamine); LUSC trans rs10435719 0.902 rs12681142 chr8:11802601 T/C cg27411982 chr8:10470053 RP1L1 0.4 6.18 0.32 1.84e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6121246 0.529 rs73235789 chr20:30196148 T/C cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.2e-10 Mean corpuscular hemoglobin; LUSC cis rs11971779 0.680 rs11765421 chr7:139025094 G/A cg23387468 chr7:139079360 LUC7L2 0.42 6.34 0.33 7.65e-10 Diisocyanate-induced asthma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19649853 chr19:39341302 HNRNPL 0.45 6.51 0.34 2.78e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs9399135 0.967 rs13218642 chr6:135309940 A/G cg22676075 chr6:135203613 NA 0.46 7.31 0.37 2.04e-12 Red blood cell count; LUSC cis rs6121246 0.567 rs6060249 chr20:30190944 G/A cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg24558204 chr6:135376177 HBS1L 0.67 10.47 0.5 2.32e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg11764359 chr7:65958608 NA -0.82 -13.78 -0.6 1.69e-34 Aortic root size; LUSC cis rs73198271 0.628 rs76079102 chr8:8591553 A/T cg01851573 chr8:8652454 MFHAS1 0.46 5.82 0.3 1.36e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs7937682 0.774 rs59921976 chr11:111473088 G/A cg18187862 chr3:45730750 SACM1L 0.5 6.39 0.33 5.48e-10 Primary sclerosing cholangitis; LUSC trans rs7819412 0.521 rs10100660 chr8:11038885 T/A cg15556689 chr8:8085844 FLJ10661 -0.5 -7.03 -0.36 1.19e-11 Triglycerides; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs55665837 1.000 rs12804549 chr11:14437758 A/T cg05501817 chr11:14380813 RRAS2 -0.4 -6.48 -0.33 3.35e-10 Vitamin D levels; LUSC trans rs62238980 0.614 rs117338064 chr22:32447147 A/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs459571 1.000 rs459571 chr9:136912626 C/T cg01294253 chr9:136912663 BRD3 0.34 5.9 0.31 8.89e-9 Platelet distribution width; LUSC cis rs10791323 0.660 rs2156681 chr11:133731644 G/T cg00579200 chr11:133705235 NA -0.39 -6.01 -0.31 4.87e-9 Childhood ear infection; LUSC cis rs9467773 0.967 rs1535276 chr6:26520941 T/C cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.64e-42 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13292458 chr18:13726614 RNMT;C18orf19 0.45 6.09 0.32 3.1e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg05585544 chr11:47624801 NA -0.41 -7.2 -0.37 3.91e-12 Subjective well-being; LUSC cis rs6845621 0.901 rs207294 chr4:18918758 C/A cg12196642 chr4:18937545 NA -0.33 -6.27 -0.32 1.1e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg09877947 chr5:131593287 PDLIM4 0.42 6.83 0.35 4.03e-11 Breast cancer;Mosquito bite size; LUSC cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg21171335 chr12:122356390 WDR66 -0.58 -8.78 -0.43 8.58e-17 Mean corpuscular volume; LUSC cis rs10782582 0.593 rs4638068 chr1:76161663 G/A cg22875332 chr1:76189707 ACADM -0.42 -6.22 -0.32 1.48e-9 Daytime sleep phenotypes; LUSC cis rs11958404 0.932 rs113494689 chr5:157428078 G/T cg05962755 chr5:157440814 NA 0.51 6.09 0.32 3.16e-9 IgG glycosylation; LUSC cis rs113835537 0.529 rs7950790 chr11:66258053 G/A cg24851651 chr11:66362959 CCS 0.53 8.0 0.4 2.03e-14 Airway imaging phenotypes; LUSC cis rs16866061 1.000 rs72974205 chr2:225408468 C/T cg12698349 chr2:225449008 CUL3 0.87 14.41 0.62 6.28e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg21724239 chr8:58056113 NA 0.77 8.43 0.42 1.07e-15 Developmental language disorder (linguistic errors); LUSC cis rs9359856 0.623 rs1179903 chr6:90321736 G/T cg13799429 chr6:90582589 CASP8AP2 -0.83 -10.1 -0.48 4.02e-21 Bipolar disorder; LUSC cis rs7131987 0.903 rs918873 chr12:29390501 G/T cg09582351 chr12:29534625 ERGIC2 -0.31 -6.49 -0.33 3.11e-10 QT interval; LUSC cis rs9443645 0.527 rs12527806 chr6:79507667 A/T cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.1 -0.32 2.87e-9 Intelligence (multi-trait analysis); LUSC cis rs6120849 0.754 rs6088667 chr20:33566722 A/C cg24642439 chr20:33292090 TP53INP2 0.54 6.22 0.32 1.44e-9 Protein C levels; LUSC cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg06552810 chr11:31128660 NA -0.42 -7.4 -0.38 1.14e-12 Red blood cell count; LUSC cis rs10754283 0.967 rs10801759 chr1:90113745 A/G cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs3768617 0.510 rs20557 chr1:183093875 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg06219351 chr7:158114137 PTPRN2 -0.52 -9.51 -0.46 3.88e-19 Calcium levels; LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg07677032 chr17:61819896 STRADA 0.54 9.04 0.44 1.33e-17 Prudent dietary pattern; LUSC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11890956 chr21:40555474 PSMG1 -0.73 -11.01 -0.52 2.9e-24 Menarche (age at onset); LUSC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg03240473 chr21:43526662 UMODL1;C21orf128 -0.59 -9.55 -0.46 2.82e-19 IgG glycosylation; LUSC cis rs7618501 1.000 rs11130218 chr3:49752372 C/T cg24110177 chr3:50126178 RBM5 0.41 6.51 0.34 2.68e-10 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg20307385 chr11:47447363 PSMC3 -0.46 -5.94 -0.31 7.15e-9 Subjective well-being; LUSC cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs911119 1.000 rs3787498 chr20:23616781 C/T cg16589663 chr20:23618590 CST3 0.6 6.99 0.36 1.48e-11 Chronic kidney disease; LUSC cis rs11098499 0.955 rs1511018 chr4:120161580 G/T cg09307838 chr4:120376055 NA 0.74 10.76 0.51 2.22e-23 Corneal astigmatism; LUSC cis rs17154702 0.524 rs2664041 chr8:8593144 A/G cg01851573 chr8:8652454 MFHAS1 0.4 6.22 0.32 1.52e-9 Neurocognitive impairment in HIV-1 infection (continuous); LUSC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg05425664 chr17:57184151 TRIM37 0.59 9.16 0.45 5.3e-18 Intelligence (multi-trait analysis); LUSC cis rs4938330 0.739 rs11216266 chr11:116950150 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.4 -0.33 5.21e-10 Blood protein levels; LUSC cis rs6964587 0.621 rs38799 chr7:92045139 C/T cg17063962 chr7:91808500 NA -0.46 -6.92 -0.35 2.33e-11 Breast cancer; LUSC cis rs3808502 0.503 rs2061830 chr8:11397457 C/G cg21775007 chr8:11205619 TDH 0.54 7.92 0.4 3.57e-14 Neuroticism; LUSC cis rs11031096 0.702 rs1015998 chr11:4150869 G/A cg18678763 chr11:4115507 RRM1 0.38 5.77 0.3 1.83e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4478137 0.501 rs6811330 chr4:164230038 G/T cg06758707 chr4:164254230 NPY1R -0.5 -6.84 -0.35 3.88e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg23758822 chr17:41437982 NA 1.04 19.44 0.73 7.67e-57 Menopause (age at onset); LUSC cis rs983392 0.709 rs7939882 chr11:59973929 A/C cg24026212 chr11:59952134 MS4A6A -0.36 -6.16 -0.32 2.05e-9 Alzheimer's disease (late onset); LUSC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg21880101 chr17:80066754 CCDC57 -0.31 -5.91 -0.31 8.52e-9 Life satisfaction; LUSC cis rs56399783 0.901 rs17132741 chr7:2868997 C/T cg19731401 chr7:2775893 GNA12 -0.63 -9.29 -0.45 2.06e-18 Childhood ear infection; LUSC cis rs2777491 1.000 rs316610 chr15:41752852 C/T cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.34 -0.59 7.96e-33 Ulcerative colitis; LUSC cis rs10751667 0.560 rs10902265 chr11:1003642 G/A cg06064525 chr11:970664 AP2A2 -0.3 -5.9 -0.31 8.76e-9 Alzheimer's disease (late onset); LUSC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg09034736 chr1:150693464 HORMAD1 0.4 5.72 0.3 2.34e-8 Melanoma; LUSC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg06108461 chr20:60628389 TAF4 -0.94 -14.72 -0.63 3.87e-38 Body mass index; LUSC cis rs68170813 0.641 rs74524528 chr7:107090979 G/A cg02696742 chr7:106810147 HBP1 -0.66 -9.66 -0.47 1.21e-19 Coronary artery disease; LUSC cis rs1969363 0.531 rs11495331 chr12:38110702 A/G cg26384229 chr12:38710491 ALG10B 0.61 8.94 0.44 2.64e-17 Morning vs. evening chronotype; LUSC cis rs1577917 0.958 rs10944136 chr6:86448499 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.89 -0.35 2.81e-11 Response to antipsychotic treatment; LUSC cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 18.1 0.7 1.66e-51 Chronic sinus infection; LUSC cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg05347473 chr6:146136440 FBXO30 -0.59 -10.25 -0.49 1.3e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs1728785 0.901 rs11865339 chr16:68565296 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs4148883 0.603 rs6833176 chr4:100131163 G/C cg12011299 chr4:100065546 ADH4 -0.41 -6.54 -0.34 2.29e-10 Alcohol dependence; LUSC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg10018233 chr7:150070692 REPIN1 0.34 6.08 0.32 3.23e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs1801251 1.000 rs13008942 chr2:233594875 G/A cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.33 3.01e-10 Coronary artery disease; LUSC cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg17509989 chr5:176798049 RGS14 -0.67 -10.73 -0.51 2.91e-23 Hemoglobin concentration;Hematocrit; LUSC cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg18477163 chr1:228402036 OBSCN -0.55 -10.16 -0.49 2.62e-21 Diastolic blood pressure; LUSC cis rs2635047 0.935 rs2461247 chr18:44698537 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.68 0.34 1.02e-10 Educational attainment; LUSC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg19468946 chr17:37922297 IKZF3 -0.37 -5.85 -0.3 1.16e-8 Self-reported allergy; LUSC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg17179660 chr6:151773299 C6orf211;RMND1 -0.41 -6.22 -0.32 1.48e-9 Menarche (age at onset); LUSC cis rs9527 0.830 rs12249194 chr10:104643698 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -6.54 -0.34 2.28e-10 Arsenic metabolism; LUSC cis rs11098499 0.754 rs4443261 chr4:120249301 T/C cg24375607 chr4:120327624 NA 0.76 12.2 0.56 1.45e-28 Corneal astigmatism; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg12352820 chr6:13616043 NOL7 0.33 6.23 0.32 1.4e-9 Tuberculosis; LUSC cis rs453301 0.506 rs686189 chr8:8623637 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.16 -0.41 7.11e-15 Joint mobility (Beighton score); LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -9.0 -0.44 1.7e-17 Axial length; LUSC cis rs12145833 0.596 rs61833913 chr1:243440028 C/G cg02356786 chr1:243265016 LOC731275 0.66 6.32 0.33 8.59e-10 Obesity (early onset extreme); LUSC cis rs11711311 1.000 rs6792447 chr3:113508335 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.44 0.33 4.12e-10 IgG glycosylation; LUSC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg10253484 chr15:75165896 SCAMP2 -0.44 -6.4 -0.33 5.31e-10 Breast cancer; LUSC cis rs7220711 1.000 rs7220711 chr17:41789965 C/T cg26893861 chr17:41843967 DUSP3 -0.42 -5.92 -0.31 7.97e-9 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg04733989 chr22:42467013 NAGA -0.61 -9.5 -0.46 4.27e-19 Schizophrenia; LUSC trans rs62387962 1.000 rs62389053 chr5:157290951 C/T cg09066361 chr7:126890254 GRM8 0.49 6.46 0.33 3.81e-10 Platelet distribution width; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.63 0.65 9.98e-42 Platelet count; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg16199381 chr9:100396477 TSTD2;NCBP1 0.43 6.35 0.33 6.89e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 7.84e-17 Prudent dietary pattern; LUSC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg03351412 chr1:154909251 PMVK 0.56 8.9 0.44 3.73e-17 Prostate cancer; LUSC cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg21433313 chr16:3507492 NAT15 0.68 11.44 0.53 8.55e-26 Tuberculosis; LUSC cis rs868036 1.000 rs884202 chr15:68054388 G/A cg05925327 chr15:68127851 NA 0.33 5.91 0.31 8.43e-9 Restless legs syndrome; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg24405498 chr19:1556284 MEX3D -0.42 -6.3 -0.33 9.61e-10 N-glycan levels; LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.1 0.61 9.47e-36 Platelet count; LUSC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.08 -0.36 8.82e-12 Major depressive disorder; LUSC cis rs6445797 0.632 rs2291499 chr3:56658481 G/C cg13792233 chr3:56591045 CCDC66 0.41 5.72 0.3 2.33e-8 Gastritis; LUSC trans rs724744 0.742 rs1205919 chr6:22365242 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.01 -0.31 4.75e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg23093090 chr10:104574429 C10orf26 -0.45 -7.91 -0.4 3.82e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.52 0.53 4.36e-26 Prudent dietary pattern; LUSC cis rs9467773 0.620 rs1027204 chr6:26639613 T/C cg09904177 chr6:26538194 HMGN4 0.65 11.7 0.54 9.83e-27 Intelligence (multi-trait analysis); LUSC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg10792982 chr14:105748885 BRF1 0.51 9.35 0.46 1.29e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs9549367 0.789 rs2287247 chr13:113889212 A/G cg00898013 chr13:113819073 PROZ -0.56 -8.07 -0.4 1.29e-14 Platelet distribution width; LUSC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.45 6.3 0.33 9.29e-10 Tonsillectomy; LUSC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg02428538 chr16:24856791 SLC5A11 -0.56 -5.85 -0.3 1.17e-8 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.706 rs594794 chr17:37453485 T/C cg07936489 chr17:37558343 FBXL20 0.78 9.96 0.48 1.27e-20 Glomerular filtration rate (creatinine); LUSC cis rs9595066 0.627 rs4942287 chr13:44734696 C/T cg04068111 chr13:44716778 NA 0.45 5.89 0.31 9.43e-9 Schizophrenia; LUSC cis rs2854160 0.581 rs2727319 chr17:61960215 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 8.4 0.42 1.31e-15 Height; LUSC cis rs6062509 0.839 rs3859579 chr20:62301795 A/G cg27236539 chr20:62289627 RTEL1 0.53 7.07 0.36 8.87e-12 Prostate cancer; LUSC cis rs2290416 0.892 rs62522168 chr8:144679776 G/A cg26536354 chr8:144654954 C8orf73 0.67 7.31 0.37 2.05e-12 Attention deficit hyperactivity disorder; LUSC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Parkinson's disease; LUSC cis rs7615952 0.932 rs3811679 chr3:125648283 A/G cg05084668 chr3:125655381 ALG1L -0.79 -11.9 -0.55 1.87e-27 Blood pressure (smoking interaction); LUSC cis rs4888262 0.545 rs36097721 chr16:74648267 C/G cg01733217 chr16:74700730 RFWD3 0.8 13.34 0.59 8.02e-33 Testicular germ cell tumor; LUSC trans rs61931739 0.517 rs4104182 chr12:34081343 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.48 0.42 7.21e-16 Morning vs. evening chronotype; LUSC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg24642439 chr20:33292090 TP53INP2 -0.48 -7.37 -0.37 1.35e-12 Glomerular filtration rate (creatinine); LUSC cis rs1559088 1.000 rs7260051 chr19:33550111 C/A cg03563238 chr19:33554763 RHPN2 -0.41 -6.49 -0.33 3.19e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs2389217 0.509 rs2389219 chr12:33722185 T/A cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs997295 0.618 rs3784698 chr15:68007582 G/C cg24579218 chr15:68104479 NA 0.35 5.97 0.31 5.94e-9 Motion sickness; LUSC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg05861140 chr6:150128134 PCMT1 -0.44 -7.13 -0.36 6.26e-12 Lung cancer; LUSC cis rs9527 0.668 rs7092815 chr10:104736345 G/T cg23093090 chr10:104574429 C10orf26 -0.39 -6.99 -0.36 1.48e-11 Arsenic metabolism; LUSC trans rs11696501 0.694 rs1487325 chr20:44258989 A/G cg03272292 chr12:48577362 C12orf68 -0.51 -6.14 -0.32 2.31e-9 Brain structure; LUSC cis rs11190604 0.943 rs3750632 chr10:102279295 G/C cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4148883 0.545 rs17595102 chr4:99986316 C/G cg12011299 chr4:100065546 ADH4 0.45 7.19 0.37 4.16e-12 Alcohol dependence; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg24675658 chr1:53192096 ZYG11B -0.61 -9.64 -0.47 1.43e-19 Monocyte count; LUSC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -8.24 -0.41 3.91e-15 Blood pressure (smoking interaction); LUSC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.76 -9.95 -0.48 1.31e-20 Age-related macular degeneration (geographic atrophy); LUSC cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg05347473 chr6:146136440 FBXO30 0.4 6.63 0.34 1.34e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs3790645 1.000 rs34062688 chr1:26887150 A/G cg17456097 chr1:26900765 RPS6KA1 0.41 6.01 0.31 4.9e-9 Glucose homeostasis traits; LUSC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.790 rs2254288 chr6:146204470 G/A cg05347473 chr6:146136440 FBXO30 0.56 9.66 0.47 1.28e-19 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G ch.15.381296F chr15:40219076 NA 0.44 6.26 0.32 1.19e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg15448220 chr1:150897856 SETDB1 0.41 6.02 0.31 4.61e-9 Melanoma; LUSC cis rs62400317 0.859 rs17209636 chr6:45142517 T/G cg18551225 chr6:44695536 NA -0.43 -6.92 -0.35 2.37e-11 Total body bone mineral density; LUSC trans rs61931739 0.890 rs1687020 chr12:34137924 G/C cg26384229 chr12:38710491 ALG10B 0.56 8.78 0.43 8.54e-17 Morning vs. evening chronotype; LUSC cis rs3833788 1 rs3833788 chr12:121151062 CTCTCTTG/C cg21892295 chr12:121157589 UNC119B -0.51 -9.33 -0.45 1.47e-18 Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.82 0.39 6.95e-14 Prudent dietary pattern; LUSC trans rs877282 0.842 rs35117541 chr10:764683 C/T cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs34638657 0.789 rs2967363 chr16:82204132 C/G cg09439754 chr16:82129088 HSD17B2 -0.4 -6.67 -0.34 1.05e-10 Lung adenocarcinoma; LUSC cis rs11608355 0.810 rs2217972 chr12:109857612 C/T cg19025524 chr12:109796872 NA -0.38 -5.7 -0.3 2.6e-8 Neuroticism; LUSC cis rs7100689 0.646 rs6585967 chr10:82139791 A/G cg00277334 chr10:82204260 NA 0.51 7.4 0.38 1.12e-12 Post bronchodilator FEV1; LUSC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.39 0.59 5.09e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs12200782 1.000 rs72844495 chr6:26610640 T/C cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.82 0.35 4.24e-11 Tonsillectomy; LUSC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg02825527 chr7:2087843 MAD1L1 -0.51 -5.72 -0.3 2.34e-8 Bipolar disorder; LUSC cis rs2274273 1.000 rs67098772 chr14:55595242 G/A cg04306507 chr14:55594613 LGALS3 0.54 11.49 0.53 5.85e-26 Protein biomarker; LUSC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg22442454 chr1:209979470 IRF6 -0.43 -5.86 -0.31 1.12e-8 Cleft lip with or without cleft palate; LUSC cis rs11958404 1.000 rs9686690 chr5:157412103 C/T cg05962755 chr5:157440814 NA 0.51 6.24 0.32 1.32e-9 IgG glycosylation; LUSC cis rs11031096 0.754 rs4910886 chr11:4143721 G/T cg18678763 chr11:4115507 RRM1 -0.51 -7.48 -0.38 6.46e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs5758659 1.000 rs134902 chr22:42683997 C/T cg04733989 chr22:42467013 NAGA 0.41 6.73 0.35 7.34e-11 Cognitive function; LUSC cis rs11098499 0.863 rs1010740 chr4:120463409 C/T cg24375607 chr4:120327624 NA -0.75 -11.36 -0.53 1.71e-25 Corneal astigmatism; LUSC cis rs2948294 0.545 rs11776397 chr8:8115161 C/T cg06636001 chr8:8085503 FLJ10661 0.74 10.4 0.49 4.1e-22 Red cell distribution width; LUSC cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.86 -0.54 2.57e-27 Chronic sinus infection; LUSC cis rs11122272 0.701 rs2790887 chr1:231523724 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs9527 0.590 rs7087459 chr10:104790999 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.35 -0.33 6.93e-10 Arsenic metabolism; LUSC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg14664628 chr15:75095509 CSK -0.58 -8.99 -0.44 1.9e-17 Breast cancer; LUSC cis rs929354 0.685 rs1808217 chr7:157002741 T/C cg05182265 chr7:156933206 UBE3C -0.6 -9.69 -0.47 9.72e-20 Body mass index; LUSC cis rs377070 0.934 rs309397 chr4:123614323 A/C cg10495464 chr4:123653540 BBS12;LOC729338 0.48 6.74 0.35 7.12e-11 Mosquito bite size; LUSC cis rs10191773 0.522 rs6747639 chr2:112967458 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.64 -7.79 -0.39 8.55e-14 Yeast infection; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg03241282 chr3:197807491 LOC348840 0.46 6.17 0.32 2.02e-9 Neuroticism; LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.91 0.31 8.34e-9 Menopause (age at onset); LUSC cis rs7100689 0.646 rs10788562 chr10:82072310 C/T cg00277334 chr10:82204260 NA 0.58 8.87 0.44 4.36e-17 Post bronchodilator FEV1; LUSC cis rs9952991 0.941 rs2014857 chr18:12774326 C/T cg23544223 chr18:12777786 NA 0.59 6.25 0.32 1.26e-9 Inflammatory skin disease; LUSC cis rs10911232 0.560 rs10911221 chr1:183046737 G/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.9 0.51 6.87e-24 Hypertriglyceridemia; LUSC cis rs10744422 1.000 rs4993320 chr12:123338092 T/C cg25930673 chr12:123319894 HIP1R -0.72 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg02018176 chr4:1364513 KIAA1530 0.75 13.67 0.6 4.11e-34 Longevity; LUSC cis rs3784262 0.967 rs12148907 chr15:58296450 T/A cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.93 -0.31 7.51e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs453301 0.686 rs4840389 chr8:8884503 G/C cg15556689 chr8:8085844 FLJ10661 -0.62 -9.89 -0.48 2.14e-20 Joint mobility (Beighton score); LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg10802521 chr3:52805072 NEK4 -0.56 -8.72 -0.43 1.33e-16 Bipolar disorder; LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg16405210 chr4:1374714 KIAA1530 0.55 8.23 0.41 4.21e-15 Obesity-related traits; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg26338869 chr17:61819248 STRADA 0.42 6.06 0.31 3.7e-9 Prudent dietary pattern; LUSC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg18225595 chr11:63971243 STIP1 0.54 9.21 0.45 3.81e-18 Platelet count; LUSC trans rs7937682 0.889 rs1789361 chr11:111485334 T/C cg18187862 chr3:45730750 SACM1L 0.54 7.09 0.36 8.05e-12 Primary sclerosing cholangitis; LUSC cis rs7107174 0.892 rs7115850 chr11:78045071 C/G cg02023728 chr11:77925099 USP35 0.45 6.71 0.34 8.21e-11 Testicular germ cell tumor; LUSC cis rs11030122 0.702 rs7950153 chr11:3951337 T/C cg18678763 chr11:4115507 RRM1 -0.43 -5.67 -0.3 3.06e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs9467773 1.000 rs9467796 chr6:26568411 A/G cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC cis rs9549367 0.713 rs4907598 chr13:113861385 C/T cg00898013 chr13:113819073 PROZ 0.58 8.58 0.42 3.72e-16 Platelet distribution width; LUSC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs4601821 0.965 rs10891543 chr11:113255895 A/G cg14159747 chr11:113255604 NA 0.25 5.93 0.31 7.68e-9 Alcoholic chronic pancreatitis; LUSC cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg21535247 chr6:8435926 SLC35B3 0.6 9.27 0.45 2.37e-18 Motion sickness; LUSC cis rs727505 1.000 rs720613 chr7:124452670 C/T cg23710748 chr7:124431027 NA -0.41 -7.36 -0.37 1.46e-12 Lewy body disease; LUSC cis rs7605827 0.780 rs2287278 chr2:15667771 C/G cg19274914 chr2:15703543 NA 0.46 9.06 0.44 1.12e-17 Educational attainment (years of education); LUSC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg13206674 chr6:150067644 NUP43 0.64 10.5 0.5 1.8e-22 Lung cancer; LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg08280861 chr8:58055591 NA 0.54 6.47 0.33 3.4e-10 Developmental language disorder (linguistic errors); LUSC cis rs9653442 0.593 rs10865036 chr2:100860595 A/G cg07810366 chr2:100720526 AFF3 -0.39 -6.33 -0.33 7.84e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6545883 0.931 rs778765 chr2:61786385 A/T cg15711740 chr2:61764176 XPO1 -0.48 -7.52 -0.38 5.04e-13 Tuberculosis; LUSC cis rs8141797 0.901 rs176159 chr22:24514352 A/G cg00411358 chr22:24577142 SUSD2 0.57 6.13 0.32 2.46e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg02423579 chr7:2872169 GNA12 -0.4 -6.14 -0.32 2.4e-9 Height; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg13685833 chr1:53393034 SCP2 0.46 6.76 0.35 6.1e-11 Monocyte count; LUSC trans rs12682352 0.715 rs332039 chr8:8723651 C/G cg21775007 chr8:11205619 TDH 0.44 6.15 0.32 2.27e-9 Neuroticism; LUSC cis rs10875746 0.903 rs10875735 chr12:48463806 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg23796481 chr11:64053134 BAD;GPR137 0.51 8.05 0.4 1.49e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs17401966 0.838 rs17034643 chr1:10332102 A/G cg19773385 chr1:10388646 KIF1B 0.5 8.59 0.43 3.28e-16 Hepatocellular carcinoma; LUSC cis rs6693567 0.545 rs4970922 chr1:150458094 C/A cg15654264 chr1:150340011 RPRD2 0.43 6.92 0.35 2.34e-11 Migraine; LUSC cis rs10504229 0.500 rs9772760 chr8:57986999 G/C cg11062466 chr8:58055876 NA 0.38 5.68 0.3 2.98e-8 Developmental language disorder (linguistic errors); LUSC cis rs9948 0.655 rs56913233 chr2:97405896 A/G cg01990225 chr2:97406019 LMAN2L -1.03 -7.11 -0.36 7.29e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs34891900 0.507 rs9605364 chr22:18127437 G/A cg19898043 chr22:18121309 BCL2L13 0.41 6.25 0.32 1.25e-9 Sum neutrophil eosinophil counts; LUSC cis rs500891 0.525 rs6454320 chr6:84050814 C/T cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.08e-14 Platelet-derived growth factor BB levels; LUSC cis rs5758511 0.773 rs62240997 chr22:42354567 T/G cg00645731 chr22:42541494 CYP2D7P1 0.44 7.24 0.37 3.08e-12 Birth weight; LUSC cis rs992157 0.798 rs2382818 chr2:219155907 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.01 -0.36 1.3e-11 Colorectal cancer; LUSC cis rs4474465 0.790 rs6592784 chr11:78234790 C/T cg27205649 chr11:78285834 NARS2 0.53 6.14 0.32 2.34e-9 Alzheimer's disease (survival time); LUSC cis rs62400317 0.859 rs72860105 chr6:45265201 A/T cg20913747 chr6:44695427 NA -0.45 -7.42 -0.38 9.97e-13 Total body bone mineral density; LUSC cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg03146154 chr1:46216737 IPP -0.51 -7.42 -0.38 9.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1997103 1.000 rs10249105 chr7:55412405 A/G cg20935933 chr6:143382018 AIG1 -0.51 -7.57 -0.38 3.65e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1044826 1.000 rs13089007 chr3:139095587 T/C cg00490450 chr3:139108681 COPB2 0.56 7.42 0.38 9.5e-13 Obesity-related traits; LUSC cis rs6964587 0.773 rs17757926 chr7:91987702 T/C cg17063962 chr7:91808500 NA 0.52 7.54 0.38 4.45e-13 Breast cancer; LUSC cis rs6120849 0.754 rs6120788 chr20:33583716 C/T cg24642439 chr20:33292090 TP53INP2 0.63 6.85 0.35 3.52e-11 Protein C levels; LUSC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg00745463 chr17:30367425 LRRC37B -0.76 -9.31 -0.45 1.78e-18 Hip circumference adjusted for BMI; LUSC cis rs12900413 0.645 rs28407340 chr15:90311864 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.82 -0.3 1.37e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg10729496 chr3:10149963 C3orf24 0.52 6.88 0.35 2.9100000000000002e-11 Alzheimer's disease; LUSC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs4713118 0.516 rs4713142 chr6:28106347 T/G cg06606381 chr12:133084897 FBRSL1 -0.45 -5.97 -0.31 6.07e-9 Parkinson's disease; LUSC cis rs6121246 0.909 rs6060679 chr20:30270772 C/G cg18721089 chr20:30220636 NA 0.36 6.18 0.32 1.88e-9 Mean corpuscular hemoglobin; LUSC cis rs2692947 0.702 rs2312955 chr2:96777168 T/G cg22654517 chr2:96458247 NA -0.32 -5.85 -0.3 1.19e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7759001 0.779 rs13215216 chr6:27346645 G/C cg18711553 chr6:27366782 ZNF391 0.41 5.95 0.31 6.67e-9 Glomerular filtration rate (creatinine); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15539190 chr13:28024404 MTIF3 -0.4 -6.13 -0.32 2.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16983817 chr21:15399683 NA -0.45 -6.49 -0.33 3.09e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.73 0.35 7.22e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs3741151 0.686 rs7935948 chr11:73219118 A/G cg17517138 chr11:73019481 ARHGEF17 -0.79 -7.51 -0.38 5.35e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10949834 0.504 rs12539781 chr7:73568425 C/T cg07137043 chr7:73588983 EIF4H -0.53 -6.22 -0.32 1.5e-9 Verbal memory performance (residualized delayed recall change); LUSC cis rs11048434 0.736 rs12423746 chr12:9113002 G/T cg23795048 chr12:9217529 LOC144571 0.34 5.89 0.31 9.24e-9 Sjögren's syndrome; LUSC trans rs1392935 0.831 rs11654419 chr17:49973935 C/T cg17187048 chr2:122407283 CLASP1 -0.57 -6.09 -0.32 3.06e-9 Bacterial meningitis; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.36 5.65 0.3 3.49e-8 Lymphocyte counts; LUSC cis rs983392 0.678 rs7108663 chr11:60028142 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.1 0.32 2.95e-9 Alzheimer's disease (late onset); LUSC cis rs6121246 0.567 rs6060399 chr20:30220823 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.18 -0.32 1.83e-9 Mean corpuscular hemoglobin; LUSC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg17911788 chr17:44343683 NA -0.3 -5.88 -0.31 9.84e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg08439880 chr3:133502540 NA -0.36 -6.51 -0.34 2.73e-10 Iron status biomarkers; LUSC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg14343924 chr8:8086146 FLJ10661 0.43 6.19 0.32 1.75e-9 Mood instability; LUSC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg00033643 chr7:134001901 SLC35B4 0.45 6.95 0.36 1.92e-11 Mean platelet volume; LUSC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg26513180 chr16:89883248 FANCA 0.79 6.38 0.33 5.88e-10 Skin colour saturation; LUSC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg03233332 chr7:66118400 NA -0.4 -5.92 -0.31 8.15e-9 Aortic root size; LUSC cis rs7527798 1.000 rs12744104 chr1:207819000 G/A cg09232269 chr1:207846808 CR1L -0.32 -5.77 -0.3 1.84e-8 Erythrocyte sedimentation rate; LUSC cis rs1775715 0.811 rs1775741 chr10:32267284 C/T cg04359828 chr10:32216031 ARHGAP12 -0.39 -6.49 -0.33 3.14e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs751728 0.626 rs6457741 chr6:33756026 C/T cg25922239 chr6:33757077 LEMD2 0.42 6.25 0.32 1.24e-9 Crohn's disease; LUSC cis rs7089973 0.872 rs35010779 chr10:116631816 A/C cg23260525 chr10:116636907 FAM160B1 0.39 7.99 0.4 2.23e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs1459104 0.866 rs35456973 chr11:54838812 C/A cg03929089 chr4:120376271 NA 0.68 6.03 0.31 4.28e-9 Body mass index; LUSC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg17264618 chr3:40429014 ENTPD3 0.34 7.18 0.37 4.56e-12 Renal cell carcinoma; LUSC cis rs7605827 0.930 rs7598068 chr2:15596535 A/T cg19274914 chr2:15703543 NA 0.47 8.98 0.44 2.02e-17 Educational attainment (years of education); LUSC cis rs737008 0.922 rs376374 chr16:11370616 G/A cg00044050 chr16:11439710 C16orf75 -0.55 -8.54 -0.42 4.82e-16 Obesity-related traits; LUSC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg00990874 chr7:1149470 C7orf50 -0.54 -6.47 -0.33 3.57e-10 Bronchopulmonary dysplasia; LUSC cis rs2439831 0.681 rs1549525 chr15:43627855 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.92 10.84 0.51 1.16e-23 Lung cancer in ever smokers; LUSC trans rs62238980 0.521 rs117792024 chr22:32379444 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg11062466 chr8:58055876 NA 0.46 6.1 0.32 2.86e-9 Developmental language disorder (linguistic errors); LUSC cis rs77972916 0.611 rs11693190 chr2:43602415 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.44 -5.73 -0.3 2.27e-8 Granulocyte percentage of myeloid white cells; LUSC trans rs11696501 0.688 rs6065851 chr20:44279034 C/T cg03272292 chr12:48577362 C12orf68 0.48 6.0 0.31 5.1e-9 Brain structure; LUSC cis rs8032315 0.862 rs7166599 chr15:91403674 A/G cg05469396 chr15:91419421 FURIN -0.37 -5.67 -0.3 3.1e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs853679 0.882 rs9468287 chr6:28079741 G/T cg06606381 chr12:133084897 FBRSL1 -0.69 -7.61 -0.38 2.84e-13 Depression; LUSC trans rs116175374 0.793 rs114644732 chr2:31432074 G/C cg15543616 chr12:5019024 KCNA1 -0.77 -6.01 -0.31 4.9e-9 Endometriosis; LUSC cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.46 -0.42 8.29e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.49 7.48 0.38 6.62e-13 Eosinophil percentage of white cells; LUSC cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.36 6.02 0.31 4.71e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg19592336 chr6:28129416 ZNF389 -0.47 -6.36 -0.33 6.5e-10 Depression; LUSC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.82 -10.32 -0.49 7.4e-22 Gut microbiome composition (summer); LUSC cis rs9303401 0.659 rs1864754 chr17:56688789 G/T cg10487724 chr17:56770010 TEX14;RAD51C -0.86 -13.58 -0.6 9.19e-34 Cognitive test performance; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.17 0.41 6.44e-15 Prudent dietary pattern; LUSC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.98 0.4 2.38e-14 Parkinson's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13976219 chr19:7197166 INSR -0.54 -6.87 -0.35 3.24e-11 Bipolar disorder and schizophrenia; LUSC cis rs9814567 1.000 rs4974483 chr3:134219001 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.37 -0.59 5.8e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3087591 0.636 rs736598 chr17:29720470 T/C cg24425628 chr17:29625626 OMG;NF1 0.49 7.49 0.38 6.35e-13 Hip circumference; LUSC cis rs1580019 0.961 rs1868776 chr7:32494435 G/T cg06627557 chr7:32535165 LSM5;AVL9 -0.76 -11.59 -0.54 2.49e-26 Cognitive ability; LUSC cis rs4343996 0.967 rs7785994 chr7:3351810 T/C cg21248987 chr7:3385318 SDK1 -0.38 -6.52 -0.34 2.52e-10 Motion sickness; LUSC trans rs7613875 0.578 rs4688753 chr3:50074773 A/G cg21659725 chr3:3221576 CRBN -0.52 -8.37 -0.42 1.61e-15 Body mass index; LUSC cis rs17155006 0.746 rs429252 chr7:107745554 T/C cg05962710 chr7:107745446 LAMB4 -0.36 -6.51 -0.34 2.68e-10 Pneumococcal bacteremia; LUSC cis rs7824557 0.767 rs2060463 chr8:11161610 T/G cg21775007 chr8:11205619 TDH 0.71 11.4 0.53 1.21e-25 Retinal vascular caliber; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.1 0.52 1.39e-24 Alzheimer's disease; LUSC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg08975724 chr8:8085496 FLJ10661 0.5 7.44 0.38 8.63e-13 Mood instability; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs7809950 0.954 rs2712193 chr7:107125885 A/C cg23024343 chr7:107201750 COG5 -0.55 -8.81 -0.43 7.13e-17 Coronary artery disease; LUSC trans rs9650657 0.648 rs7833945 chr8:10700266 T/G cg15556689 chr8:8085844 FLJ10661 -0.41 -6.28 -0.32 1.07e-9 Neuroticism; LUSC cis rs2191566 0.821 rs59756444 chr19:44513656 C/G cg03039196 chr19:44506973 ZNF230 0.35 5.65 0.3 3.43e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg19346786 chr7:2764209 NA -0.48 -7.88 -0.4 4.61e-14 Height; LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.8 -0.3 1.57e-8 Platelet count; LUSC cis rs7241530 0.662 rs7235625 chr18:75906500 G/A cg14642773 chr18:75888474 NA 0.39 5.96 0.31 6.32e-9 Educational attainment (years of education); LUSC cis rs7385804 0.727 rs551238 chr7:100321528 G/T cg16850897 chr7:100343110 ZAN 0.37 5.92 0.31 7.9e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg04865166 chr7:105162814 PUS7 0.52 5.87 0.31 1.02e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9906944 0.707 rs12942084 chr17:47114392 A/G cg14634687 chr17:47094252 IGF2BP1 0.31 6.6 0.34 1.61e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg06238570 chr21:40685208 BRWD1 0.47 7.3 0.37 2.12e-12 Cognitive function; LUSC cis rs17253792 0.915 rs28537145 chr14:56179119 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21931103 chr2:99771423 LIPT1;TSGA10 0.4 6.17 0.32 2.03e-9 Triglycerides; LUSC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg02034447 chr16:89574710 SPG7 0.4 6.05 0.31 3.95e-9 Multiple myeloma (IgH translocation); LUSC cis rs380904 0.519 rs12541790 chr8:144643321 A/G cg13399544 chr8:144649678 C8orf73 -0.44 -6.85 -0.35 3.58e-11 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs763121 0.889 rs1043402 chr22:38879688 G/A cg06022373 chr22:39101656 GTPBP1 0.76 11.69 0.54 1.11e-26 Menopause (age at onset); LUSC cis rs208515 0.525 rs10755508 chr6:66675790 T/C cg07460842 chr6:66804631 NA 1.01 13.91 0.61 4.95e-35 Exhaled nitric oxide levels; LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.28e-9 Menopause (age at onset); LUSC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg06028605 chr16:24865363 SLC5A11 0.51 9.11 0.45 7.83e-18 Intelligence (multi-trait analysis); LUSC cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg00321850 chr1:175162397 KIAA0040 -0.45 -7.82 -0.39 6.91e-14 Alcohol dependence; LUSC cis rs11229555 1.000 rs11229555 chr11:58408687 G/T cg15696309 chr11:58395628 NA -0.66 -8.99 -0.44 1.83e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7584330 0.518 rs6715245 chr2:238445803 C/T cg14458575 chr2:238380390 NA 0.56 6.97 0.36 1.72e-11 Prostate cancer; LUSC cis rs5167 0.781 rs909134 chr19:45493061 T/C cg20090143 chr19:45452003 APOC2 0.34 5.81 0.3 1.44e-8 Blood protein levels; LUSC cis rs9398803 0.931 rs9375435 chr6:126661858 C/T cg19875578 chr6:126661172 C6orf173 0.43 6.27 0.32 1.09e-9 Male-pattern baldness; LUSC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg21951975 chr1:209979733 IRF6 0.55 8.23 0.41 4.3e-15 Cleft lip with or without cleft palate; LUSC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.33e-10 Height; LUSC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg03929089 chr4:120376271 NA -0.76 -12.17 -0.55 1.87e-28 Height; LUSC cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.03 0.55 6.07e-28 Chronic sinus infection; LUSC cis rs4964805 0.865 rs4964289 chr12:104204191 G/A cg02344784 chr12:104178138 NT5DC3 0.4 6.35 0.33 7.15e-10 Attention deficit hyperactivity disorder; LUSC cis rs7829975 0.539 rs940031 chr8:8546848 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.1 -0.32 2.86e-9 Mood instability; LUSC cis rs7605827 0.897 rs11675604 chr2:15672901 C/T cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.49e-16 Educational attainment (years of education); LUSC trans rs629535 0.814 rs654452 chr8:70074344 C/G cg21567404 chr3:27674614 NA 0.97 15.59 0.65 1.44e-41 Dupuytren's disease; LUSC cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg13010199 chr12:38710504 ALG10B 0.7 11.58 0.54 2.59e-26 Heart rate; LUSC cis rs6594499 0.542 rs4530809 chr5:110462230 A/G cg04022379 chr5:110408740 TSLP 0.57 8.62 0.43 2.69e-16 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20435150 chr7:2443076 CHST12 -0.48 -7.39 -0.37 1.21e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg15921436 chr17:44337874 NA 0.72 10.99 0.52 3.35e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg24812749 chr6:127587940 RNF146 0.83 12.28 0.56 7.58e-29 Breast cancer; LUSC cis rs7851660 0.809 rs7034648 chr9:100654093 C/A cg13688889 chr9:100608707 NA -0.53 -8.06 -0.4 1.36e-14 Strep throat; LUSC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg03526776 chr6:41159608 TREML2 0.33 6.12 0.32 2.67e-9 Alzheimer's disease (late onset); LUSC cis rs1801251 0.778 rs2592116 chr2:233735709 G/A cg25237894 chr2:233734115 C2orf82 -0.35 -6.6 -0.34 1.62e-10 Coronary artery disease; LUSC cis rs1728785 1.000 rs1182968 chr16:68573945 C/T cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC trans rs877282 0.945 rs11253398 chr10:790012 T/C cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs10883723 0.669 rs2001595 chr10:104395085 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 11.29 0.53 2.98e-25 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7527798 1.000 rs12745818 chr1:207819401 C/T cg09232269 chr1:207846808 CR1L -0.32 -5.77 -0.3 1.84e-8 Erythrocyte sedimentation rate; LUSC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg10556349 chr10:835070 NA 0.44 5.66 0.3 3.31e-8 Eosinophil percentage of granulocytes; LUSC cis rs7605827 0.930 rs7590458 chr2:15601574 A/G cg19274914 chr2:15703543 NA -0.44 -8.47 -0.42 7.76e-16 Educational attainment (years of education); LUSC cis rs881375 0.678 rs10985102 chr9:123707497 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 5.97 0.31 6.21e-9 Rheumatoid arthritis; LUSC cis rs6961069 0.745 rs1527479 chr7:80272568 C/T cg04458919 chr7:80252533 CD36 -0.33 -5.96 -0.31 6.37e-9 Platelet count; LUSC cis rs10875746 0.859 rs3782910 chr12:48483507 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 1.97e-8 Longevity (90 years and older); LUSC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg05234568 chr11:5960015 NA -0.55 -8.0 -0.4 2.14e-14 DNA methylation (variation); LUSC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg22823121 chr1:150693482 HORMAD1 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs9788682 1.000 rs61204066 chr15:78815298 G/A cg18825076 chr15:78729989 IREB2 0.47 6.34 0.33 7.31e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.72 -0.39 1.35e-13 Lymphocyte counts; LUSC cis rs965469 1.000 rs1040726 chr20:3264267 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -5.96 -0.31 6.56e-9 IFN-related cytopenia; LUSC trans rs66887589 0.592 rs11731571 chr4:120221185 G/A cg25214090 chr10:38739885 LOC399744 0.39 6.13 0.32 2.45e-9 Diastolic blood pressure; LUSC trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg15704280 chr7:45808275 SEPT13 0.75 8.53 0.42 5.16e-16 Axial length; LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13732083 chr21:47605072 C21orf56 -0.4 -6.06 -0.31 3.71e-9 Testicular germ cell tumor; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg20295408 chr7:1910781 MAD1L1 -0.53 -7.77 -0.39 9.86e-14 Bipolar disorder and schizophrenia; LUSC cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg16230307 chr14:35515116 FAM177A1 0.79 10.05 0.48 6.13e-21 Psoriasis; LUSC cis rs3741151 0.881 rs12099129 chr11:73091318 T/G cg17517138 chr11:73019481 ARHGEF17 1.04 8.78 0.43 8.62e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10484885 0.878 rs17763820 chr6:90569634 A/G cg13799429 chr6:90582589 CASP8AP2 -0.84 -8.14 -0.41 8.06e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs28785552 0.897 rs34244888 chr19:53242228 T/A cg10871876 chr19:53194124 ZNF83 0.56 8.65 0.43 2.15e-16 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs11098499 0.954 rs6820115 chr4:120398182 T/C cg09307838 chr4:120376055 NA 0.67 9.98 0.48 1.09e-20 Corneal astigmatism; LUSC cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg08213375 chr14:104286397 PPP1R13B 0.52 10.19 0.49 2.11e-21 Schizophrenia; LUSC cis rs4629180 0.593 rs6707517 chr2:102089878 C/T cg04415270 chr2:102091202 RFX8 -0.55 -8.91 -0.44 3.44e-17 Chronic rhinosinusitis with nasal polyps; LUSC cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg05343316 chr1:45956843 TESK2 0.74 9.99 0.48 9.68e-21 Platelet count; LUSC cis rs9467773 1.000 rs1884948 chr6:26567988 G/A cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs8062405 0.723 rs35175818 chr16:28608746 A/C cg07382826 chr16:28625726 SULT1A1 0.28 6.08 0.32 3.3e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2273669 0.667 rs76267985 chr6:109326183 A/T cg05315195 chr6:109294784 ARMC2 -0.53 -5.94 -0.31 7.15e-9 Prostate cancer; LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg10802521 chr3:52805072 NEK4 -0.51 -8.12 -0.41 9.1e-15 Bipolar disorder; LUSC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg26441486 chr22:50317300 CRELD2 0.47 6.96 0.36 1.82e-11 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21780859 chr13:30002907 MTUS2 0.36 6.13 0.32 2.46e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs12692738 0.526 rs355872 chr2:165632206 T/C cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg07741184 chr6:167504864 NA -0.36 -6.53 -0.34 2.41e-10 Crohn's disease; LUSC cis rs2227564 0.672 rs2461864 chr10:75659872 A/T cg23231163 chr10:75533350 FUT11 -0.43 -5.91 -0.31 8.36e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg23601416 chr22:19950040 COMT 0.44 9.19 0.45 4.38e-18 Blood metabolite levels; LUSC cis rs11018904 0.906 rs12793836 chr11:89953493 C/T cg26138821 chr11:89956704 CHORDC1 -0.58 -6.87 -0.35 3.19e-11 Intelligence (multi-trait analysis); LUSC cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg13010199 chr12:38710504 ALG10B 0.68 11.49 0.53 5.71e-26 Heart rate; LUSC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.17 0.41 6.27e-15 Urate levels; LUSC cis rs2130392 0.926 rs1107907 chr4:185620108 G/T cg21366198 chr4:185655624 MLF1IP -0.44 -6.24 -0.32 1.36e-9 Kawasaki disease; LUSC cis rs6977660 0.943 rs10240816 chr7:19819620 A/C cg05791153 chr7:19748676 TWISTNB 0.54 5.94 0.31 6.96e-9 Thyroid stimulating hormone; LUSC cis rs2932538 0.922 rs12750023 chr1:113118329 G/A cg22162597 chr1:113214053 CAPZA1 0.7 10.1 0.48 4.1e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg23711669 chr6:146136114 FBXO30 0.74 12.95 0.58 2.36e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs17685 0.632 rs1859793 chr7:75821283 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.61 -0.38 2.74e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg00343986 chr7:65444356 GUSB 0.39 5.76 0.3 1.91e-8 Aortic root size; LUSC cis rs9391997 0.568 rs1567900 chr6:433109 T/C cg09757644 chr6:447497 NA 0.28 5.89 0.31 9.22e-9 Chronic lymphocytic leukemia; LUSC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg17143192 chr8:8559678 CLDN23 0.39 5.94 0.31 7.02e-9 Mood instability; LUSC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg04155289 chr7:94953770 PON1 -0.35 -6.02 -0.31 4.7e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg12564285 chr5:131593104 PDLIM4 -0.32 -5.77 -0.3 1.83e-8 Breast cancer;Mosquito bite size; LUSC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg09323728 chr8:95962352 TP53INP1 -0.37 -7.49 -0.38 6.31e-13 Type 2 diabetes; LUSC cis rs4820539 1.000 rs3827316 chr22:23468538 T/C cg14186256 chr22:23484241 RTDR1 0.95 17.69 0.7 6.9e-50 Bone mineral density; LUSC cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 7.94 0.4 3.04e-14 Colorectal cancer; LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg22963979 chr7:1858916 MAD1L1 -0.56 -8.47 -0.42 7.85e-16 Schizophrenia; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg18064852 chr5:36690457 NA 0.39 6.46 0.33 3.62e-10 Mosquito bite size; LUSC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg24675056 chr1:15929824 NA 0.46 7.96 0.4 2.75e-14 Systolic blood pressure; LUSC cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg03684893 chr10:554711 DIP2C -0.38 -6.93 -0.35 2.24e-11 Psychosis in Alzheimer's disease; LUSC cis rs2625529 0.701 rs12911154 chr15:72212653 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.54 -0.38 4.35e-13 Red blood cell count; LUSC cis rs2387326 0.717 rs10829339 chr10:129943681 C/T cg16087940 chr10:129947807 NA -0.4 -5.99 -0.31 5.41e-9 Select biomarker traits; LUSC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg12863693 chr15:85201151 NMB 0.35 6.84 0.35 3.79e-11 Schizophrenia; LUSC cis rs614226 0.938 rs12857 chr12:120933946 T/G cg01236616 chr12:121019343 POP5 1.28 20.98 0.75 6.38e-63 Type 1 diabetes nephropathy; LUSC cis rs1957429 0.901 rs7143661 chr14:65378981 G/A cg23373153 chr14:65346875 NA 1.03 11.29 0.53 2.92e-25 Pediatric areal bone mineral density (radius); LUSC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg23711669 chr6:146136114 FBXO30 0.88 16.26 0.66 3.33e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs79976124 0.879 rs17511467 chr6:66627293 T/C cg07460842 chr6:66804631 NA 0.7 8.63 0.43 2.62e-16 Type 2 diabetes; LUSC cis rs2273669 0.510 rs11757590 chr6:109370003 T/C cg05315195 chr6:109294784 ARMC2 -0.52 -5.78 -0.3 1.7e-8 Prostate cancer; LUSC cis rs12760731 0.720 rs1510266 chr1:178346771 A/T cg00404053 chr1:178313656 RASAL2 -0.55 -6.34 -0.33 7.54e-10 Obesity-related traits; LUSC cis rs11122272 0.735 rs910823 chr1:231498766 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.93 -0.48 1.59e-20 Hemoglobin concentration; LUSC trans rs11250098 0.600 rs4240671 chr8:10767748 A/G cg15556689 chr8:8085844 FLJ10661 0.52 7.57 0.38 3.56e-13 Morning vs. evening chronotype; LUSC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg07828024 chr6:149772892 ZC3H12D 0.34 7.44 0.38 8.54e-13 Dupuytren's disease; LUSC cis rs2742234 0.541 rs12416428 chr10:43708998 G/A cg15436174 chr10:43711423 RASGEF1A 0.44 7.03 0.36 1.14e-11 Hirschsprung disease; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.641 rs76419201 chr16:68153553 G/A cg09835421 chr16:68378352 PRMT7 -0.55 -6.17 -0.32 1.92e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.57 7.72 0.39 1.37e-13 Lung function (FEV1/FVC); LUSC cis rs10744422 1.000 rs4759381 chr12:123348480 G/A cg25930673 chr12:123319894 HIP1R -0.67 -6.74 -0.35 6.99e-11 Schizophrenia; LUSC cis rs6681460 0.585 rs1359463 chr1:67169565 G/A cg02459107 chr1:67143332 SGIP1 0.33 5.76 0.3 1.93e-8 Presence of antiphospholipid antibodies; LUSC trans rs11039798 0.623 rs635632 chr11:48399532 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -7.1 -0.36 7.73e-12 Axial length; LUSC cis rs4654899 1.000 rs6689819 chr1:21472395 A/T cg01072550 chr1:21505969 NA -0.55 -8.42 -0.42 1.16e-15 Superior frontal gyrus grey matter volume; LUSC cis rs968451 0.813 rs5757614 chr22:39717554 G/T cg17798944 chr22:39715225 SNORD43;RPL3 0.67 8.51 0.42 6.07e-16 Primary biliary cholangitis; LUSC cis rs921665 0.749 rs4477952 chr2:3201249 G/A cg02624386 chr2:3182749 NA 0.59 6.36 0.33 6.7e-10 World class endurance athleticism; LUSC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg18876405 chr7:65276391 NA -0.55 -8.73 -0.43 1.25e-16 Aortic root size; LUSC cis rs68170813 0.523 rs11762152 chr7:106811374 G/A cg02696742 chr7:106810147 HBP1 -0.63 -9.5 -0.46 4.06e-19 Coronary artery disease; LUSC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg11752832 chr7:134001865 SLC35B4 0.61 9.6 0.46 2e-19 Mean platelet volume; LUSC cis rs981844 0.712 rs1037648 chr4:154737877 T/C cg14289246 chr4:154710475 SFRP2 -0.44 -6.17 -0.32 1.97e-9 Response to statins (LDL cholesterol change); LUSC cis rs9788682 0.747 rs2568499 chr15:78722359 T/C cg18825076 chr15:78729989 IREB2 -0.44 -6.13 -0.32 2.52e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs10986311 0.832 rs10818951 chr9:127131062 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.39 6.23 0.32 1.4e-9 Vitiligo; LUSC cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.36 -0.42 1.71e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2486288 0.656 rs1719236 chr15:45577783 G/T cg14582100 chr15:45693742 SPATA5L1 -0.42 -6.96 -0.36 1.86e-11 Glomerular filtration rate; LUSC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.84e-11 Aortic root size; LUSC cis rs11229555 0.609 rs12291791 chr11:58186290 C/T cg15696309 chr11:58395628 NA -0.64 -7.78 -0.39 9.19e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg24562669 chr7:97807699 LMTK2 0.4 6.85 0.35 3.66e-11 Breast cancer; LUSC cis rs2985684 0.846 rs10150624 chr14:50051565 A/G cg04989706 chr14:50066350 PPIL5 -0.46 -6.21 -0.32 1.57e-9 Carotid intima media thickness; LUSC cis rs10782582 0.609 rs72979226 chr1:76302222 C/A cg10523679 chr1:76189770 ACADM -0.49 -7.06 -0.36 9.81e-12 Daytime sleep phenotypes; LUSC cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg13010199 chr12:38710504 ALG10B 0.64 10.0 0.48 9.35e-21 Bladder cancer; LUSC cis rs2274273 0.805 rs28660594 chr14:55846174 T/C cg04306507 chr14:55594613 LGALS3 0.53 11.88 0.55 2.11e-27 Protein biomarker; LUSC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg12560992 chr17:57184187 TRIM37 0.8 13.95 0.61 3.66e-35 Intelligence (multi-trait analysis); LUSC cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.7 0.51 3.63e-23 Bone mineral density; LUSC cis rs11971779 0.816 rs11979272 chr7:139074069 C/T cg07862535 chr7:139043722 LUC7L2 0.74 8.31 0.41 2.47e-15 Diisocyanate-induced asthma; LUSC cis rs834603 0.575 rs1704968 chr7:47468231 T/C cg09696706 chr7:47479511 TNS3 0.32 5.75 0.3 2.01e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg15145296 chr3:125709740 NA -0.59 -6.49 -0.33 3.19e-10 Blood pressure (smoking interaction); LUSC cis rs6545883 0.929 rs12713436 chr2:61691260 T/C cg15711740 chr2:61764176 XPO1 -0.46 -7.06 -0.36 9.62e-12 Tuberculosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13353472 chr19:39343117 HNRNPL -0.53 -6.51 -0.34 2.8e-10 Bipolar disorder and schizophrenia; LUSC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg13628971 chr7:2884303 GNA12 0.37 5.67 0.3 3.02e-8 Height; LUSC cis rs2635047 0.967 rs2684820 chr18:44664304 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 7.16 0.36 5.04e-12 Educational attainment; LUSC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.69 -10.9 -0.51 6.91e-24 Monocyte percentage of white cells; LUSC cis rs4662750 0.580 rs7558838 chr2:128351346 T/C cg06107159 chr2:128432243 LIMS2 -0.32 -5.65 -0.3 3.48e-8 Renal cell carcinoma; LUSC cis rs12824058 0.831 rs11608407 chr12:130805869 G/A cg24838063 chr12:130822603 PIWIL1 0.68 10.48 0.5 2.08e-22 Menopause (age at onset); LUSC cis rs9400467 0.528 rs1623806 chr6:111665071 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.87 -0.35 3.11e-11 Blood metabolite levels;Amino acid levels; LUSC trans rs7824557 0.767 rs6991606 chr8:11176159 G/A cg06636001 chr8:8085503 FLJ10661 0.54 8.27 0.41 3.25e-15 Retinal vascular caliber; LUSC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg06481639 chr22:41940642 POLR3H -0.51 -6.14 -0.32 2.41e-9 Vitiligo; LUSC cis rs3820068 0.581 rs6429762 chr1:15945595 A/C cg17385448 chr1:15911702 AGMAT 0.35 5.99 0.31 5.54e-9 Systolic blood pressure; LUSC cis rs796364 0.762 rs13030712 chr2:200973569 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.48 6.37 0.33 6.43e-10 Schizophrenia; LUSC cis rs1448094 0.565 rs80346149 chr12:86317542 C/T cg18827107 chr12:86230957 RASSF9 -0.43 -5.67 -0.3 3.01e-8 Major depressive disorder; LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg21733973 chr7:65235735 NA 0.47 6.6 0.34 1.66e-10 Calcium levels; LUSC cis rs7267979 0.816 rs6037158 chr20:25595466 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.8 16.68 0.67 7.39e-46 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg14829155 chr15:31115871 NA -0.72 -10.47 -0.5 2.24e-22 Huntington's disease progression; LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg23758822 chr17:41437982 NA 1.03 18.74 0.72 4.56e-54 Menopause (age at onset); LUSC cis rs2742234 0.910 rs2505511 chr10:43641029 T/A cg15436174 chr10:43711423 RASGEF1A -0.36 -6.41 -0.33 4.92e-10 Hirschsprung disease; LUSC cis rs3008870 1.000 rs7511948 chr1:67430427 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.25 0.64 3.15e-40 Lymphocyte percentage of white cells; LUSC cis rs17034641 1.000 rs17034641 chr2:46372644 G/A cg12428440 chr2:46370979 PRKCE 0.46 6.2 0.32 1.65e-9 Hemoglobin;Hematocrit; LUSC cis rs9287719 0.901 rs13034017 chr2:10739592 C/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs10752881 1.000 rs6673559 chr1:182983197 G/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.53 0.5 1.37e-22 Colorectal cancer; LUSC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg18350739 chr11:68623251 NA -0.37 -6.48 -0.33 3.24e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs453301 0.606 rs7462373 chr8:8899318 G/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.37 -0.37 1.37e-12 Joint mobility (Beighton score); LUSC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg16423285 chr20:60520624 NA -0.47 -5.94 -0.31 6.99e-9 Body mass index; LUSC cis rs3818285 0.544 rs7899805 chr10:111671177 G/A cg00817464 chr10:111662876 XPNPEP1 -0.64 -9.44 -0.46 6.49e-19 Superior crus of antihelix expression; LUSC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg23758822 chr17:41437982 NA 1.04 19.19 0.72 7.41e-56 Menopause (age at onset); LUSC cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg24562669 chr7:97807699 LMTK2 0.47 8.5 0.42 6.62e-16 Breast cancer; LUSC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg11247378 chr22:39784982 NA -0.66 -12.93 -0.58 2.78e-31 Intelligence (multi-trait analysis); LUSC cis rs79387448 0.745 rs7593444 chr2:103158561 G/A cg09003973 chr2:102972529 NA 0.88 8.56 0.42 4.18e-16 Gut microbiota (bacterial taxa); LUSC cis rs9733 0.540 rs4971041 chr1:150537357 C/T cg09365446 chr1:150670422 GOLPH3L -0.41 -5.93 -0.31 7.68e-9 Tonsillectomy; LUSC cis rs72781680 0.898 rs6545127 chr2:24060670 C/T cg20701182 chr2:24300061 SF3B14 0.56 6.01 0.31 4.81e-9 Lymphocyte counts; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17461462 chr8:627771 ERICH1 -0.75 -6.4 -0.33 5.39e-10 Cognitive performance; LUSC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg15448220 chr1:150897856 SETDB1 0.42 6.06 0.31 3.68e-9 Melanoma; LUSC cis rs8072100 0.688 rs8079142 chr17:45442049 G/A cg08085267 chr17:45401833 C17orf57 -0.51 -7.18 -0.37 4.58e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1691799 0.899 rs1168293 chr12:66733904 G/A cg16791601 chr12:66731901 HELB -0.73 -12.34 -0.56 4.27e-29 White blood cell count (basophil); LUSC cis rs6547741 1.000 rs4666009 chr2:27857992 T/A cg27432699 chr2:27873401 GPN1 0.81 14.95 0.63 4.58e-39 Oral cavity cancer; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg00684032 chr4:1343700 KIAA1530 0.36 6.64 0.34 1.24e-10 Longevity; LUSC trans rs11098499 0.954 rs11729521 chr4:120416788 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg21782813 chr7:2030301 MAD1L1 0.44 7.43 0.38 9.1e-13 Schizophrenia; LUSC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg04450456 chr4:17643702 FAM184B 0.39 6.61 0.34 1.49e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1865760 0.663 rs9379815 chr6:25980116 T/A cg16482183 chr6:26056742 HIST1H1C 0.46 6.91 0.35 2.41e-11 Height; LUSC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg01448562 chr3:133502909 NA -0.5 -7.46 -0.38 7.63e-13 Iron status biomarkers; LUSC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg17143192 chr8:8559678 CLDN23 0.65 9.05 0.44 1.21e-17 Obesity-related traits; LUSC trans rs12510870 0.511 rs6834059 chr4:74301675 C/G cg01940055 chr4:146018582 ANAPC10;ABCE1 0.39 6.54 0.34 2.35e-10 Iris color (b* coordinate); LUSC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg23719950 chr11:63933701 MACROD1 -0.64 -8.2 -0.41 5.19e-15 Mean platelet volume; LUSC cis rs7937682 0.889 rs558736 chr11:111500760 C/G cg22437258 chr11:111473054 SIK2 0.53 7.15 0.36 5.55e-12 Primary sclerosing cholangitis; LUSC trans rs11039798 0.920 rs12417899 chr11:49017552 G/A cg15704280 chr7:45808275 SEPT13 0.86 7.18 0.37 4.49e-12 Axial length; LUSC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg01973587 chr1:228161476 NA -0.41 -7.4 -0.38 1.15e-12 Diastolic blood pressure; LUSC cis rs1371867 0.875 rs1660311 chr8:101330579 C/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg14784868 chr12:69753453 YEATS4 0.57 7.48 0.38 6.74e-13 Response to diuretic therapy; LUSC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs11676348 0.772 rs11676275 chr2:218944808 G/A cg06547715 chr2:218990976 CXCR2 0.31 6.01 0.31 4.74e-9 Ulcerative colitis; LUSC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03264133 chr6:25882463 NA 0.48 7.96 0.4 2.79e-14 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25632093 chr22:29999554 NF2 -0.4 -6.03 -0.31 4.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7192380 1.000 rs7192380 chr16:69704342 T/C cg26679644 chr16:69762563 NA 0.35 6.2 0.32 1.65e-9 Sjögren's syndrome; LUSC trans rs7829975 0.714 rs11777085 chr8:8672429 G/C cg21775007 chr8:11205619 TDH 0.43 6.08 0.32 3.26e-9 Mood instability; LUSC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00475322 chr7:917719 C7orf20 0.45 6.59 0.34 1.68e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs1538970 0.962 rs9429072 chr1:45810091 C/T cg05343316 chr1:45956843 TESK2 -0.56 -7.88 -0.4 4.75e-14 Platelet count; LUSC cis rs6424115 0.618 rs10917420 chr1:24062987 C/T cg10978503 chr1:24200527 CNR2 0.37 8.34 0.42 2.01e-15 Immature fraction of reticulocytes; LUSC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1143633 0.566 rs12987491 chr2:113691499 G/A cg06156847 chr2:113672199 IL1F7 0.29 6.34 0.33 7.31e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg13770153 chr20:60521292 NA -0.64 -8.87 -0.44 4.64e-17 Body mass index; LUSC trans rs1493916 0.748 rs4799355 chr18:31313124 G/T cg27147174 chr7:100797783 AP1S1 -0.55 -8.74 -0.43 1.19e-16 Life satisfaction; LUSC cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg05283184 chr6:79620031 NA -0.57 -12.14 -0.55 2.33e-28 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg06850241 chr22:41845214 NA 0.3 5.77 0.3 1.84e-8 Vitiligo; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20908936 chr7:113726250 NA -0.4 -5.97 -0.31 6.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg12463550 chr7:65579703 CRCP -0.42 -6.46 -0.33 3.66e-10 Aortic root size; LUSC trans rs11098499 0.909 rs1809406 chr4:120377122 G/A cg25214090 chr10:38739885 LOC399744 0.54 8.02 0.4 1.78e-14 Corneal astigmatism; LUSC cis rs2017854 0.562 rs1583319 chr17:65500961 A/T cg07622687 chr17:65503465 PITPNC1 0.44 7.63 0.39 2.49e-13 Pulmonary function; LUSC cis rs3106136 0.934 rs34396188 chr4:95191292 A/C cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.18 -0.32 1.92e-9 Capecitabine sensitivity; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg08219700 chr8:58056026 NA 0.64 8.09 0.4 1.09e-14 Developmental language disorder (linguistic errors); LUSC cis rs67460515 0.852 rs2404341 chr3:161092405 T/C cg03342759 chr3:160939853 NMD3 -0.53 -7.34 -0.37 1.64e-12 Parkinson's disease; LUSC cis rs71636778 0.543 rs71636796 chr1:27243095 T/C cg12203394 chr1:27248618 NUDC 0.53 5.65 0.3 3.36e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg07606381 chr6:8435919 SLC35B3 0.74 12.49 0.56 1.21e-29 Motion sickness; LUSC cis rs897080 0.515 rs698818 chr2:44709769 G/A cg00619915 chr2:44497795 NA -0.42 -6.01 -0.31 4.83e-9 Height; LUSC cis rs5758511 0.773 rs7288749 chr22:42356430 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.51 -6.24 -0.32 1.34e-9 Birth weight; LUSC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg11247378 chr22:39784982 NA -0.66 -12.83 -0.57 6.31e-31 Intelligence (multi-trait analysis); LUSC cis rs3741151 0.773 rs73546720 chr11:73252409 C/T cg17517138 chr11:73019481 ARHGEF17 0.97 8.12 0.41 8.78e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg21643547 chr1:205240462 TMCC2 -0.52 -9.94 -0.48 1.43e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg03146154 chr1:46216737 IPP 0.5 7.43 0.38 9.1e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2625529 0.652 rs2899775 chr15:72268354 C/T cg16672083 chr15:72433130 SENP8 0.48 7.92 0.4 3.52e-14 Red blood cell count; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg06873352 chr17:61820015 STRADA 0.71 12.72 0.57 1.68e-30 Prudent dietary pattern; LUSC trans rs57221529 0.766 rs12522303 chr5:555564 A/C cg08313168 chr12:7315531 NA 0.46 5.98 0.31 5.65e-9 Lung disease severity in cystic fibrosis; LUSC cis rs4076764 0.846 rs12036398 chr1:163422204 C/T cg06092702 chr1:163392909 NA 0.41 6.87 0.35 3.06e-11 Motion sickness; LUSC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg08219700 chr8:58056026 NA 0.46 6.02 0.31 4.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs1538970 0.781 rs713358 chr1:45988267 C/G cg06784218 chr1:46089804 CCDC17 0.35 5.99 0.31 5.39e-9 Platelet count; LUSC trans rs11098499 0.863 rs13140391 chr4:120503437 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.0 0.4 2.12e-14 Corneal astigmatism; LUSC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg21770322 chr7:97807741 LMTK2 0.44 7.74 0.39 1.22e-13 Breast cancer; LUSC trans rs9847048 0.715 rs62271998 chr3:116370362 A/C cg11621464 chr19:41120268 LTBP4 -0.61 -5.99 -0.31 5.32e-9 Gut microbiome composition (summer); LUSC trans rs459571 0.959 rs416390 chr9:136908549 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.78 13.24 0.59 1.94e-32 Platelet distribution width; LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 15.59 0.65 1.47e-41 Platelet count; LUSC cis rs6543140 0.964 rs4851589 chr2:103077145 A/G cg09003973 chr2:102972529 NA 0.53 7.01 0.36 1.34e-11 Blood protein levels; LUSC trans rs2727020 0.553 rs10839295 chr11:49527345 A/C cg03929089 chr4:120376271 NA -0.95 -16.03 -0.66 2.64e-43 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03812724 chr21:15588363 RBM11 0.45 6.31 0.33 8.95e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg18758796 chr5:131593413 PDLIM4 -0.38 -6.46 -0.33 3.65e-10 Breast cancer; LUSC cis rs317689 0.684 rs315125 chr12:69758884 C/T cg11871910 chr12:69753446 YEATS4 0.63 8.34 0.42 1.97e-15 Response to diuretic therapy; LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.18 0.61 4.74e-36 Platelet count; LUSC cis rs6693567 0.545 rs2133129 chr1:150355537 T/C cg15654264 chr1:150340011 RPRD2 0.45 7.24 0.37 3.09e-12 Migraine; LUSC cis rs7246657 1.000 rs6508710 chr19:37749886 A/G cg23950597 chr19:37808831 NA -0.63 -7.38 -0.37 1.31e-12 Coronary artery calcification; LUSC cis rs11648785 0.777 rs4433810 chr16:90098466 G/T cg16611967 chr16:90144006 NA 0.47 6.13 0.32 2.48e-9 Tanning; LUSC cis rs225245 0.755 rs226432 chr17:34043825 G/A cg05299278 chr17:33885742 SLFN14 -0.29 -6.3 -0.33 9.54e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg12432903 chr7:1882776 MAD1L1 -0.39 -6.4 -0.33 5.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg13683864 chr3:40499215 RPL14 -1.01 -16.92 -0.68 7.96e-47 Renal cell carcinoma; LUSC cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg08999081 chr20:33150536 PIGU 0.54 11.01 0.52 2.88e-24 Glomerular filtration rate (creatinine); LUSC cis rs2073300 1.000 rs6137960 chr20:23442886 G/A cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs683250 1.000 rs523494 chr11:83312379 G/A cg26617787 chr11:123396133 GRAMD1B -0.31 -5.97 -0.31 5.96e-9 Subcortical brain region volumes; LUSC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg10523679 chr1:76189770 ACADM -0.78 -10.59 -0.5 8.39e-23 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6547741 1.000 rs6749052 chr2:27772879 A/T cg27432699 chr2:27873401 GPN1 0.79 14.87 0.63 9.46e-39 Oral cavity cancer; LUSC cis rs2540226 0.816 rs12623545 chr2:39977565 T/C cg23576258 chr2:39999331 THUMPD2 0.36 6.09 0.32 3.03e-9 Personality dimensions; LUSC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.9 0.35 2.56e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg00990874 chr7:1149470 C7orf50 -0.54 -6.72 -0.35 7.74e-11 Bronchopulmonary dysplasia; LUSC cis rs6684514 1.000 rs12117903 chr1:156311165 G/T cg16558208 chr1:156270281 VHLL 0.35 5.71 0.3 2.54e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs73198271 0.960 rs73198288 chr8:8613940 G/A cg01851573 chr8:8652454 MFHAS1 0.59 8.43 0.42 1.04e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs61931739 0.517 rs10844815 chr12:34245150 G/A cg26384229 chr12:38710491 ALG10B 0.73 11.91 0.55 1.7e-27 Morning vs. evening chronotype; LUSC cis rs12912251 0.948 rs34281605 chr15:38989674 G/A cg01338139 chr15:38987640 C15orf53 -0.51 -7.11 -0.36 7.04e-12 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs1371867 0.875 rs2439456 chr8:101336874 C/T cg06636551 chr8:101224915 SPAG1 -0.41 -7.5 -0.38 5.99e-13 Atrioventricular conduction; LUSC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg14500267 chr11:67383377 NA 0.32 6.14 0.32 2.29e-9 Mean corpuscular volume; LUSC trans rs7937682 0.575 rs1346180 chr11:111715570 G/C cg18187862 chr3:45730750 SACM1L -0.5 -6.17 -0.32 1.95e-9 Primary sclerosing cholangitis; LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.92 0.66 7.26e-43 Platelet count; LUSC cis rs12760731 0.720 rs12048834 chr1:178353998 A/G cg00404053 chr1:178313656 RASAL2 0.64 6.59 0.34 1.76e-10 Obesity-related traits; LUSC cis rs7072216 0.727 rs942808 chr10:100168102 C/A cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg07677032 chr17:61819896 STRADA 0.54 8.72 0.43 1.3e-16 Prudent dietary pattern; LUSC cis rs6460942 0.558 rs4330594 chr7:12278615 G/A cg06484146 chr7:12443880 VWDE -0.53 -5.72 -0.3 2.32e-8 Coronary artery disease; LUSC cis rs11051970 0.879 rs2733682 chr12:32574608 G/A cg02745156 chr12:32552066 NA 0.43 7.35 0.37 1.58e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9329221 0.905 rs28507213 chr8:10250849 C/T cg21775007 chr8:11205619 TDH -0.55 -7.96 -0.4 2.68e-14 Neuroticism; LUSC trans rs459571 0.629 rs441233 chr9:136876021 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.79 14.41 0.62 6.2e-37 Platelet distribution width; LUSC cis rs7605827 0.930 rs7577512 chr2:15623218 G/T cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs11098499 0.618 rs28491261 chr4:120294900 C/A cg09307838 chr4:120376055 NA 0.78 11.19 0.52 6.99e-25 Corneal astigmatism; LUSC cis rs9837602 1.000 rs10049383 chr3:99748548 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.2 0.32 1.64e-9 Breast cancer; LUSC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg18404041 chr3:52824283 ITIH1 0.39 6.78 0.35 5.48e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B -0.54 -9.46 -0.46 5.87e-19 IgG glycosylation; LUSC cis rs12421382 0.659 rs57978015 chr11:109385473 T/C cg16359550 chr11:109292809 C11orf87 0.37 6.46 0.33 3.71e-10 Schizophrenia; LUSC cis rs847577 0.630 rs2132276 chr7:97826340 G/A cg24562669 chr7:97807699 LMTK2 0.48 8.56 0.42 4.31e-16 Breast cancer; LUSC cis rs10078 0.571 rs2721014 chr5:463539 G/A cg08916839 chr5:415575 AHRR 0.76 7.18 0.37 4.43e-12 Fat distribution (HIV); LUSC cis rs7824557 0.527 rs2572446 chr8:11239565 C/T cg21775007 chr8:11205619 TDH -0.67 -10.57 -0.5 9.86e-23 Retinal vascular caliber; LUSC trans rs208515 0.525 rs10944870 chr6:66687757 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.34 0.62 1.09e-36 Exhaled nitric oxide levels; LUSC cis rs790123 0.692 rs796892 chr3:122385402 C/T cg00926285 chr3:122398533 PARP14 0.4 5.86 0.31 1.11e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.65 -0.54 1.53e-26 Schizophrenia; LUSC cis rs9300255 0.568 rs1790102 chr12:123704890 G/A cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs454510 0.826 rs347903 chr1:120192431 C/T cg16322792 chr1:120165303 ZNF697 0.34 5.66 0.3 3.3e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs861020 0.606 rs657844 chr1:210006873 T/G cg05527609 chr1:210001259 C1orf107 0.67 9.59 0.46 2.09e-19 Orofacial clefts; LUSC cis rs2288073 0.801 rs2384008 chr2:24373150 A/G cg20701182 chr2:24300061 SF3B14 0.49 6.28 0.33 1.04e-9 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.45 -0.33 3.95e-10 Total body bone mineral density; LUSC trans rs6561151 0.681 rs2121037 chr13:44471317 C/T cg12856521 chr11:46389249 DGKZ 0.74 9.23 0.45 3.25e-18 Crohn's disease; LUSC trans rs2730260 0.867 rs2730264 chr7:158843109 A/G cg06713098 chr7:45960367 IGFBP3 0.39 5.99 0.31 5.48e-9 Myopia (pathological); LUSC cis rs9926296 0.632 rs7206546 chr16:89799079 C/T cg26513180 chr16:89883248 FANCA -0.56 -8.69 -0.43 1.71e-16 Vitiligo; LUSC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11890956 chr21:40555474 PSMG1 -1.01 -19.72 -0.73 6.2e-58 Cognitive function; LUSC cis rs4423214 1.000 rs7935125 chr11:71184190 C/A cg05163923 chr11:71159392 DHCR7 0.75 11.19 0.52 6.57e-25 Vitamin D levels; LUSC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg22437258 chr11:111473054 SIK2 0.51 7.08 0.36 8.78e-12 Primary sclerosing cholangitis; LUSC cis rs2839186 0.934 rs17182538 chr21:47705673 C/A cg05896524 chr21:47604654 C21orf56 0.4 5.8 0.3 1.52e-8 Testicular germ cell tumor; LUSC cis rs2115536 0.704 rs2163005 chr15:80194480 A/G cg00225070 chr15:80189496 MTHFS 0.57 7.96 0.4 2.62e-14 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg05313129 chr8:58192883 C8orf71 -0.5 -6.86 -0.35 3.28e-11 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg06873352 chr17:61820015 STRADA 0.7 12.62 0.57 3.9e-30 Prudent dietary pattern; LUSC cis rs4555082 1.000 rs4277291 chr14:105759009 A/G cg13114125 chr14:105738426 BRF1 -0.86 -14.21 -0.61 3.63e-36 Mean platelet volume;Platelet distribution width; LUSC cis rs17001868 0.568 rs9611310 chr22:40733777 A/G cg07138101 chr22:40742427 ADSL 0.64 7.62 0.38 2.72e-13 Mammographic density (dense area); LUSC cis rs7493 0.950 rs7802171 chr7:95030321 A/G cg04155289 chr7:94953770 PON1 -0.34 -5.68 -0.3 2.97e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6674970 1.000 rs6676190 chr1:151079317 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.44 -5.98 -0.31 5.72e-9 Childhood ear infection; LUSC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.91 0.31 8.27e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.68 10.5 0.5 1.79e-22 Monocyte percentage of white cells; LUSC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.46e-10 Total body bone mineral density; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg09877947 chr5:131593287 PDLIM4 -0.45 -6.94 -0.36 2.02e-11 Breast cancer; LUSC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg05368731 chr17:41323189 NBR1 0.85 14.24 0.61 2.82e-36 Menopause (age at onset); LUSC cis rs6580649 0.941 rs4589362 chr12:48478664 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs11190604 1.000 rs11190595 chr10:102291761 T/C cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs533581 0.866 rs2968474 chr16:88970566 A/G cg08484992 chr16:88977278 CBFA2T3 -0.33 -5.88 -0.31 1.02e-8 Social autistic-like traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16088692 chr2:170440797 PPIG -0.41 -5.98 -0.31 5.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11122272 0.735 rs2749714 chr1:231538634 G/C cg06096015 chr1:231504339 EGLN1 0.56 9.79 0.47 4.46e-20 Hemoglobin concentration; LUSC cis rs7927771 0.864 rs4752838 chr11:47466006 G/A cg20135002 chr11:47629003 NA -0.49 -7.66 -0.39 2.09e-13 Subjective well-being; LUSC cis rs6489882 0.867 rs7306205 chr12:113366899 A/G cg20102336 chr12:113376681 OAS3 -0.39 -5.65 -0.3 3.46e-8 Chronic lymphocytic leukemia; LUSC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg19346786 chr7:2764209 NA -0.52 -8.68 -0.43 1.74e-16 Height; LUSC trans rs6089829 0.926 rs1060491 chr20:61665817 C/A cg15934090 chr1:100435551 SLC35A3 -0.47 -7.84 -0.39 6.21e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.11 0.61 8.37e-36 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4481887 0.676 rs1544177 chr1:248524683 C/G cg26353448 chr1:248524236 OR2T4 -0.31 -6.12 -0.32 2.61e-9 Common traits (Other); LUSC cis rs757110 0.770 rs11024268 chr11:17387982 A/G cg15432903 chr11:17409602 KCNJ11 0.61 10.83 0.51 1.26e-23 Type 2 diabetes; LUSC cis rs6546550 0.935 rs4241261 chr2:70063660 A/G cg02498382 chr2:70120550 SNRNP27 -0.28 -6.99 -0.36 1.54e-11 Prevalent atrial fibrillation; LUSC cis rs2762353 0.935 rs1165153 chr6:25817789 A/G cg15691649 chr6:25882328 NA -0.37 -5.84 -0.3 1.26e-8 Blood metabolite levels; LUSC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg02428538 chr16:24856791 SLC5A11 -0.53 -6.11 -0.32 2.72e-9 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.7 -0.47 9.34e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs709400 0.628 rs6575984 chr14:103876454 A/G cg12935359 chr14:103987150 CKB 0.54 8.37 0.42 1.58e-15 Body mass index; LUSC trans rs7786808 0.712 rs2335170 chr7:158207101 G/A cg02030672 chr11:45687055 CHST1 0.5 7.88 0.4 4.66e-14 Obesity-related traits; LUSC cis rs7192380 0.737 rs7204433 chr16:69589924 A/G cg00738113 chr16:70207722 CLEC18C -0.28 -6.03 -0.31 4.33e-9 Sjögren's syndrome; LUSC cis rs67539049 1.000 rs3021518 chr8:11296049 T/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.38 -5.77 -0.3 1.77e-8 Itch intensity from mosquito bite; LUSC trans rs208520 0.690 rs1318604 chr6:66825278 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.48 -0.69 4.87e-49 Exhaled nitric oxide output; LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg06873352 chr17:61820015 STRADA 0.69 11.76 0.54 6.19e-27 Prudent dietary pattern; LUSC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg15924583 chr3:47045470 NBEAL2 -0.38 -6.6 -0.34 1.57e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs4729127 1.000 rs8180725 chr7:94010953 G/C cg19058453 chr19:9879420 ZNF846 0.59 5.99 0.31 5.45e-9 Intelligence; LUSC cis rs7903847 0.642 rs10882909 chr10:99137998 G/C cg08345082 chr10:99160200 RRP12 -0.38 -7.68 -0.39 1.72e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs7589342 1.000 rs7589342 chr2:106433478 C/T cg16077055 chr2:106428750 NCK2 0.38 7.26 0.37 2.75e-12 Addiction; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg01516881 chr6:292596 DUSP22 -0.55 -8.1 -0.41 1.06e-14 Menopause (age at onset); LUSC cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg22709100 chr7:91322751 NA -0.39 -5.66 -0.3 3.19e-8 Breast cancer; LUSC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg09455208 chr3:40491958 NA 0.56 10.19 0.49 2e-21 Renal cell carcinoma; LUSC cis rs1595825 1.000 rs1440087 chr2:198871476 G/C cg19156104 chr2:198669113 PLCL1 -0.46 -5.68 -0.3 2.91e-8 Ulcerative colitis; LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.31 -0.41 2.42e-15 Gut microbiome composition (summer); LUSC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.43 -0.38 9.29e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs730566 1.000 rs730566 chr3:48487048 G/T cg07636037 chr3:49044803 WDR6 -0.52 -7.31 -0.37 2.01e-12 Prion diseases; LUSC cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg15691649 chr6:25882328 NA -0.39 -6.37 -0.33 6.13e-10 Blood metabolite levels; LUSC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg17264618 chr3:40429014 ENTPD3 0.31 6.13 0.32 2.5e-9 Renal cell carcinoma; LUSC cis rs2667011 0.756 rs4401175 chr2:160842687 G/A cg06573604 chr2:160760825 LY75 -0.49 -6.31 -0.33 8.97e-10 Bilirubin levels; LUSC cis rs926938 0.583 rs12401670 chr1:115244337 C/T cg12756093 chr1:115239321 AMPD1 -0.55 -7.87 -0.4 4.99e-14 Autism; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg00024416 chr22:24240387 NA -0.33 -6.11 -0.32 2.78e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7215564 0.908 rs35374347 chr17:78642244 C/T cg09596252 chr17:78655493 RPTOR 0.58 6.08 0.32 3.38e-9 Myopia (pathological); LUSC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg12257692 chr3:49977190 RBM6 0.25 6.92 0.35 2.29e-11 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -7.28 -0.37 2.41e-12 Electroencephalogram traits; LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg05313129 chr8:58192883 C8orf71 -0.51 -5.75 -0.3 1.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs4629710 0.645 rs35561719 chr6:131551244 G/A cg12700074 chr6:131571435 AKAP7 -0.36 -5.96 -0.31 6.33e-9 Multiple myeloma (IgH translocation); LUSC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg09365446 chr1:150670422 GOLPH3L -0.52 -7.56 -0.38 3.89e-13 Blood protein levels; LUSC cis rs12681288 0.676 rs935819 chr8:1021814 T/C cg04851639 chr8:1020857 NA -0.4 -8.26 -0.41 3.56e-15 Schizophrenia; LUSC cis rs66887589 0.934 rs4834792 chr4:120555696 T/A cg24375607 chr4:120327624 NA -0.47 -7.23 -0.37 3.27e-12 Diastolic blood pressure; LUSC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg06634786 chr22:41940651 POLR3H -0.51 -5.97 -0.31 6.08e-9 Vitiligo; LUSC cis rs9467773 0.873 rs9295698 chr6:26566099 T/A cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.31e-21 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.810 rs7767711 chr6:79810700 G/A cg05283184 chr6:79620031 NA -0.54 -11.02 -0.52 2.75e-24 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg26335602 chr6:28129616 ZNF389 0.44 5.94 0.31 6.98e-9 Parkinson's disease; LUSC cis rs4253772 1.000 rs4253772 chr22:46627603 C/T cg09491104 chr22:46646882 C22orf40 -0.63 -6.52 -0.34 2.57e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg05802129 chr4:122689817 NA -0.5 -8.12 -0.41 9.17e-15 Type 2 diabetes; LUSC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg16339924 chr4:17578868 LAP3 0.59 9.2 0.45 3.85e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1322512 0.611 rs1028651 chr6:152937865 T/C cg27316956 chr6:152958899 SYNE1 -0.36 -5.94 -0.31 7.06e-9 Tonometry; LUSC cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg23583168 chr7:148888333 NA -0.92 -17.29 -0.69 2.73e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs983392 0.679 rs1026255 chr11:60029949 A/G cg20284999 chr11:59952153 MS4A6A -0.39 -6.51 -0.34 2.77e-10 Alzheimer's disease (late onset); LUSC cis rs6696846 0.765 rs61822568 chr1:205081166 C/G cg03948781 chr1:205179583 DSTYK 0.33 6.46 0.33 3.63e-10 Red blood cell count; LUSC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg03351412 chr1:154909251 PMVK 0.46 7.16 0.36 5.3e-12 Prostate cancer; LUSC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg12257692 chr3:49977190 RBM6 -0.26 -7.33 -0.37 1.75e-12 Intelligence (multi-trait analysis); LUSC cis rs2120019 0.938 rs8030089 chr15:75290377 C/T cg11632617 chr15:75315747 PPCDC -0.52 -6.72 -0.35 7.75e-11 Blood trace element (Zn levels); LUSC cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.84 -0.39 6.19e-14 Schizophrenia; LUSC cis rs9283706 0.689 rs12517976 chr5:66321579 G/A cg11590213 chr5:66331682 MAST4 0.47 6.75 0.35 6.56e-11 Coronary artery disease; LUSC cis rs7247513 0.964 rs12979795 chr19:12717847 C/T cg01871581 chr19:12707946 ZNF490 0.57 9.16 0.45 5.27e-18 Bipolar disorder; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.78 0.77 4.41e-66 Prudent dietary pattern; LUSC cis rs9611565 0.573 rs9306355 chr22:42111896 A/T cg17376030 chr22:41985996 PMM1 -0.42 -5.69 -0.3 2.76e-8 Vitiligo; LUSC cis rs77956314 0.515 rs4238051 chr12:117366299 A/G cg02017074 chr12:117425053 FBXW8 0.66 7.55 0.38 4.13e-13 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs2404602 0.735 rs2454454 chr15:76823647 A/G cg23625390 chr15:77176239 SCAPER -0.56 -8.85 -0.44 5.21e-17 Blood metabolite levels; LUSC cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs11785693 0.862 rs73183618 chr8:4988340 T/C cg26367366 chr8:4980734 NA 0.77 9.15 0.45 5.86e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.46 7.32 0.37 1.89e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg02038168 chr22:39784481 NA -0.48 -7.64 -0.39 2.36e-13 Intelligence (multi-trait analysis); LUSC trans rs11935423 0.778 rs6839296 chr4:100492817 G/A cg02164153 chr5:172068145 NEURL1B -0.47 -6.1 -0.32 3e-9 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg21724239 chr8:58056113 NA 0.81 8.84 0.44 5.66e-17 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.8 0.43 7.21e-17 Menopause (age at onset); LUSC cis rs1967309 0.625 rs730242 chr16:4070433 C/T cg00061520 chr16:4070371 ADCY9 0.4 8.19 0.41 5.54e-15 Response to Dalcetrapib treatment in acute coronary syndrome; LUSC cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg00631329 chr6:26305371 NA 0.45 8.87 0.44 4.62e-17 Educational attainment; LUSC cis rs7408868 0.563 rs11085949 chr19:15296917 G/T cg14696996 chr19:15285081 NOTCH3 0.78 7.86 0.4 5.32e-14 Pulse pressure; LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg02475777 chr4:1388615 CRIPAK -0.41 -6.0 -0.31 5.1e-9 Obesity-related traits; LUSC trans rs7726839 0.526 rs55647623 chr5:567747 T/C cg11887960 chr12:57824829 NA 0.47 6.47 0.33 3.48e-10 Obesity-related traits; LUSC cis rs981844 1.000 rs2251639 chr4:154656410 T/C cg14289246 chr4:154710475 SFRP2 0.5 6.26 0.32 1.2e-9 Response to statins (LDL cholesterol change); LUSC cis rs7178572 0.568 rs62008452 chr15:77591007 A/G cg22256960 chr15:77711686 NA -0.51 -8.04 -0.4 1.63e-14 Type 2 diabetes; LUSC cis rs10744422 0.800 rs2649902 chr12:123243687 G/A cg25930673 chr12:123319894 HIP1R -0.58 -5.98 -0.31 5.68e-9 Schizophrenia; LUSC cis rs208520 0.690 rs851459 chr6:66813989 A/G cg07460842 chr6:66804631 NA -1.14 -18.11 -0.7 1.5e-51 Exhaled nitric oxide output; LUSC cis rs2235544 1.000 rs2235544 chr1:54375570 A/C cg25741118 chr1:54482237 LDLRAD1 -0.28 -6.29 -0.33 1e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg17264618 chr3:40429014 ENTPD3 0.33 6.93 0.35 2.23e-11 Renal cell carcinoma; LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg05025164 chr4:1340916 KIAA1530 0.45 6.87 0.35 3.19e-11 Obesity-related traits; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -9.96 -0.48 1.28e-20 Alzheimer's disease; LUSC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg18681998 chr4:17616180 MED28 0.85 16.06 0.66 2.03e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9473147 0.516 rs1485780 chr6:47556630 A/C cg20196966 chr6:47445060 CD2AP 0.41 5.75 0.3 2.07e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs1983170 1.000 rs12563578 chr1:91993702 T/C cg25838465 chr1:92012736 NA 0.47 6.57 0.34 1.92e-10 Eosinophil percentage of white cells; LUSC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg12927641 chr6:109611667 NA -0.34 -5.8 -0.3 1.52e-8 Reticulocyte fraction of red cells; LUSC cis rs2425143 1.000 rs7261284 chr20:34244104 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.21 -0.32 1.58e-9 Blood protein levels; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg16261398 chr11:1410750 BRSK2 0.31 6.01 0.31 4.73e-9 Metabolite levels (Pyroglutamine); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13098082 chr7:149290 NA 0.44 6.12 0.32 2.64e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6558174 0.930 rs12676084 chr8:22493350 C/T cg03733263 chr8:22462867 KIAA1967 0.46 6.08 0.32 3.28e-9 Breast cancer; LUSC trans rs75804782 0.641 rs72987328 chr2:239360097 C/T cg01134436 chr17:81009848 B3GNTL1 0.66 6.41 0.33 4.82e-10 Morning vs. evening chronotype;Chronotype; LUSC trans rs8072100 0.870 rs10432035 chr17:45624913 G/C cg03886242 chr7:26192032 NFE2L3 0.37 6.17 0.32 1.99e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3125734 0.633 rs12217669 chr10:63988456 A/G cg19640130 chr10:64028056 RTKN2 0.43 7.61 0.38 2.8e-13 Rheumatoid arthritis; LUSC cis rs2019216 0.542 rs3829569 chr17:21909222 T/C cg22648282 chr17:21454238 C17orf51 -0.5 -7.42 -0.38 1e-12 Pelvic organ prolapse; LUSC cis rs2742417 1.000 rs2742386 chr3:45756310 A/C cg04837898 chr3:45731254 SACM1L -0.34 -5.73 -0.3 2.26e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.79 -0.57 9.23e-31 Platelet count; LUSC cis rs796364 0.789 rs1653297 chr2:201075483 C/T cg23649088 chr2:200775458 C2orf69 0.58 8.41 0.42 1.21e-15 Schizophrenia; LUSC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg07636037 chr3:49044803 WDR6 0.44 6.38 0.33 5.9e-10 Resting heart rate; LUSC cis rs9815354 0.812 rs73073229 chr3:42007850 T/C cg03022575 chr3:42003672 ULK4 0.82 8.57 0.42 3.93e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs62400317 0.762 rs12211922 chr6:44847210 A/G cg18551225 chr6:44695536 NA -0.47 -7.5 -0.38 5.71e-13 Total body bone mineral density; LUSC cis rs9653442 0.863 rs10865035 chr2:100835734 A/G cg07810366 chr2:100720526 AFF3 -0.46 -8.17 -0.41 6.53e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg22907277 chr7:1156413 C7orf50 0.72 10.48 0.5 2.17e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12541635 1.000 rs1540420 chr8:107088426 C/T cg10147462 chr8:107024639 NA -0.48 -8.76 -0.43 1.03e-16 Age of smoking initiation; LUSC trans rs7824557 0.603 rs11250130 chr8:11214455 C/T cg15556689 chr8:8085844 FLJ10661 -0.57 -8.67 -0.43 1.88e-16 Retinal vascular caliber; LUSC cis rs9457247 0.602 rs10484530 chr6:167461562 C/T cg06454157 chr6:167490870 NA -0.3 -7.03 -0.36 1.19e-11 Crohn's disease; LUSC trans rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.54 -0.34 2.36e-10 Endometrial cancer; LUSC cis rs62400317 0.762 rs756 chr6:44795772 C/T cg20913747 chr6:44695427 NA -0.47 -7.28 -0.37 2.35e-12 Total body bone mineral density; LUSC cis rs4588572 0.644 rs2115435 chr5:77723700 A/C cg11547950 chr5:77652471 NA -0.45 -6.73 -0.35 7.33e-11 Triglycerides; LUSC cis rs9494145 0.680 rs9402686 chr6:135427817 G/A cg22676075 chr6:135203613 NA 0.63 8.9 0.44 3.53e-17 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs7589342 0.536 rs7562892 chr2:106396212 C/T cg14210321 chr2:106509881 NCK2 -0.4 -5.73 -0.3 2.28e-8 Addiction; LUSC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg02951883 chr7:2050386 MAD1L1 -0.59 -10.67 -0.5 4.43e-23 Bipolar disorder and schizophrenia; LUSC trans rs629535 0.911 rs627382 chr8:70014081 C/T cg21567404 chr3:27674614 NA -0.96 -15.16 -0.64 6.97e-40 Dupuytren's disease; LUSC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg08219700 chr8:58056026 NA 0.5 6.21 0.32 1.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg12639453 chr1:2035780 PRKCZ 0.32 6.88 0.35 2.93e-11 Height; LUSC cis rs920590 0.758 rs1817836 chr8:19664852 T/C cg03894339 chr8:19674705 INTS10 0.51 6.83 0.35 4.07e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs61931739 0.500 rs1843736 chr12:34012080 C/G cg06521331 chr12:34319734 NA -0.48 -7.67 -0.39 1.84e-13 Morning vs. evening chronotype; LUSC cis rs7084921 0.579 rs11597870 chr10:101847857 T/C cg02250046 chr10:101825185 CPN1 -0.35 -6.2 -0.32 1.63e-9 Bone mineral density; LUSC cis rs7712401 0.541 rs6867714 chr5:122382059 T/G cg19077854 chr5:122220652 SNX24 0.38 7.98 0.4 2.32e-14 Mean platelet volume; LUSC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg15145296 chr3:125709740 NA -0.58 -6.52 -0.34 2.63e-10 Blood pressure (smoking interaction); LUSC cis rs7100689 0.784 rs11202699 chr10:82131453 A/G cg00277334 chr10:82204260 NA -0.49 -6.71 -0.34 8.2e-11 Post bronchodilator FEV1; LUSC cis rs1003719 0.591 rs2018521 chr21:38517264 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.52 -8.09 -0.4 1.12e-14 Eye color traits; LUSC cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.48 0.56 1.35e-29 Motion sickness; LUSC cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg24812749 chr6:127587940 RNF146 0.9 13.18 0.58 3.2e-32 Breast cancer; LUSC cis rs7267979 1.000 rs6050544 chr20:25320228 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.08 -0.74 2.32e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2637266 1.000 rs7098929 chr10:78361194 T/G cg18941641 chr10:78392320 NA 0.4 7.45 0.38 7.84e-13 Pulmonary function; LUSC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg15704280 chr7:45808275 SEPT13 -1.13 -24.98 -0.81 2.08e-78 Height; LUSC trans rs28647808 0.786 rs28458971 chr9:136255736 C/T cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs4293296 0.525 rs75175834 chr14:54825714 T/C cg02257953 chr14:54816093 NA -0.45 -6.34 -0.33 7.57e-10 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs12579753 1.000 rs17749267 chr12:82178308 A/G cg07988820 chr12:82153109 PPFIA2 0.42 5.98 0.31 5.71e-9 Resting heart rate; LUSC cis rs6433857 0.505 rs16867320 chr2:181362312 A/G cg23363182 chr2:181467187 NA 0.44 7.04 0.36 1.1e-11 Body mass index; LUSC cis rs10089 1.000 rs4835945 chr5:127526481 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.56 0.53 3.19e-26 Ileal carcinoids; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.57 0.78 3.62e-69 Prudent dietary pattern; LUSC cis rs9399135 0.967 rs4896120 chr6:135293512 C/G cg22676075 chr6:135203613 NA 0.49 7.59 0.38 3.26e-13 Red blood cell count; LUSC cis rs2303759 0.670 rs45549132 chr19:49794028 G/T cg22307029 chr19:49891270 CCDC155 0.6 7.7 0.39 1.51e-13 Multiple sclerosis; LUSC cis rs300703 0.719 rs423314 chr2:195372 A/G cg21211680 chr2:198530 NA 0.73 8.23 0.41 4.28e-15 Blood protein levels; LUSC cis rs12310956 0.532 rs10844707 chr12:33936089 T/C cg06521331 chr12:34319734 NA -0.46 -7.36 -0.37 1.45e-12 Morning vs. evening chronotype; LUSC cis rs8062405 0.755 rs62034350 chr16:28562256 A/G cg16576597 chr16:28551801 NUPR1 0.34 6.88 0.35 2.9100000000000002e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7940866 0.845 rs2324314 chr11:130834589 A/C cg12179176 chr11:130786555 SNX19 0.62 9.66 0.47 1.27e-19 Schizophrenia; LUSC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg20135002 chr11:47629003 NA -0.51 -7.88 -0.4 4.74e-14 Subjective well-being; LUSC cis rs7809950 1.000 rs10276604 chr7:107216738 C/T cg23024343 chr7:107201750 COG5 0.53 8.4 0.42 1.3e-15 Coronary artery disease; LUSC cis rs920590 0.523 rs4464983 chr8:19680979 C/T cg03894339 chr8:19674705 INTS10 -0.44 -6.26 -0.32 1.16e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs7180079 1.000 rs8031895 chr15:64487863 C/A cg08069370 chr15:64387884 SNX1 -0.52 -5.7 -0.3 2.67e-8 Monocyte count; LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.7e-19 Menopause (age at onset); LUSC cis rs2070433 0.534 rs2839269 chr21:47891491 A/G cg12379764 chr21:47803548 PCNT 0.61 8.77 0.43 9.46e-17 Lymphocyte counts; LUSC cis rs10911363 0.592 rs2275675 chr1:183439483 C/T cg09173681 chr1:183549694 NCF2 -0.65 -11.85 -0.54 2.91e-27 Systemic lupus erythematosus; LUSC cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.39 0.33 5.42e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs68170813 0.559 rs7800443 chr7:106910723 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg12219531 chr12:120966889 COQ5 0.57 7.67 0.39 1.86e-13 High light scatter reticulocyte count; LUSC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg11632617 chr15:75315747 PPCDC -0.53 -6.89 -0.35 2.78e-11 Blood trace element (Zn levels); LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg18110333 chr6:292329 DUSP22 -0.53 -7.87 -0.4 4.98e-14 Menopause (age at onset); LUSC cis rs9527 0.590 rs7898770 chr10:104756636 A/G cg23093090 chr10:104574429 C10orf26 0.34 6.26 0.32 1.15e-9 Arsenic metabolism; LUSC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg26039829 chr8:22132926 PIWIL2 0.43 8.22 0.41 4.68e-15 Hypertriglyceridemia; LUSC cis rs644799 0.544 rs499637 chr11:95569183 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.64 9.47 0.46 5.47e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg17264618 chr3:40429014 ENTPD3 0.35 7.53 0.38 4.81e-13 Renal cell carcinoma; LUSC cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg24812749 chr6:127587940 RNF146 0.92 13.86 0.6 7.98e-35 Breast cancer; LUSC trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg11887960 chr12:57824829 NA 0.58 7.11 0.36 7.27e-12 Lung disease severity in cystic fibrosis; LUSC cis rs929596 0.755 rs4148324 chr2:234672722 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.65 -11.04 -0.52 2.35e-24 Total bilirubin levels in HIV-1 infection; LUSC cis rs10752881 1.000 rs10797813 chr1:182989366 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.94e-22 Colorectal cancer; LUSC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg06713675 chr4:122721982 EXOSC9 -0.44 -7.77 -0.39 9.93e-14 Type 2 diabetes; LUSC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg18827107 chr12:86230957 RASSF9 -0.46 -6.83 -0.35 3.98e-11 Major depressive disorder; LUSC cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg06784218 chr1:46089804 CCDC17 0.52 10.63 0.5 6.36e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs61931739 0.500 rs3924705 chr12:34557825 A/T cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs734999 0.869 rs61054170 chr1:2498052 C/T cg18854424 chr1:2615690 NA 0.47 9.71 0.47 8.81e-20 Ulcerative colitis; LUSC cis rs6696846 0.765 rs61822565 chr1:205077332 T/C cg03948781 chr1:205179583 DSTYK 0.33 6.46 0.33 3.66e-10 Red blood cell count; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg14159672 chr1:205819179 PM20D1 0.85 15.36 0.64 1.22e-40 Menarche (age at onset); LUSC cis rs2273669 0.667 rs12374597 chr6:109346184 A/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs10191773 0.589 rs72831641 chr2:112955815 A/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.73 7.68 0.39 1.76e-13 Yeast infection; LUSC cis rs2274273 0.870 rs61210954 chr14:55765402 T/C cg04306507 chr14:55594613 LGALS3 0.56 13.14 0.58 4.36e-32 Protein biomarker; LUSC trans rs12145833 0.665 rs78871868 chr1:243422322 C/T cg01826367 chr1:224180288 NA 0.67 6.03 0.31 4.42e-9 Obesity (early onset extreme); LUSC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg12863693 chr15:85201151 NMB 0.34 6.8 0.35 4.75e-11 Schizophrenia; LUSC cis rs1577917 1.000 rs12665321 chr6:86769289 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.46 -0.42 8.72e-16 Response to antipsychotic treatment; LUSC cis rs2425143 1.000 rs733609 chr20:34393074 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.72 -0.3 2.41e-8 Blood protein levels; LUSC cis rs240764 0.658 rs9322181 chr6:101221630 C/A cg09795085 chr6:101329169 ASCC3 -0.45 -6.34 -0.33 7.43e-10 Neuroticism; LUSC cis rs2295359 1.000 rs10889661 chr1:67625309 T/A cg03340356 chr1:67600835 NA 0.4 6.54 0.34 2.31e-10 Psoriasis; LUSC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.79 0.35 5.24e-11 Intelligence (multi-trait analysis); LUSC trans rs7939886 0.920 rs76702940 chr11:55999305 G/A cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 6.97 0.36 1.73e-11 Bipolar disorder; LUSC cis rs8017423 0.967 rs7147809 chr14:90715025 A/G cg14092571 chr14:90743983 NA -0.36 -5.79 -0.3 1.64e-8 Mortality in heart failure; LUSC cis rs7772486 0.875 rs1412080 chr6:146417304 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -6.69 -0.34 9.63e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11360819 chr6:15663360 DTNBP1 -0.48 -6.66 -0.34 1.13e-10 Hepatitis; LUSC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.43 6.09 0.32 3.13e-9 Height; LUSC cis rs4706831 0.663 rs1984242 chr6:81051245 A/G cg08355045 chr6:80787529 NA 0.48 8.22 0.41 4.5e-15 Joint mobility (Beighton score); LUSC trans rs853679 0.607 rs13208096 chr6:28225311 C/G cg01620082 chr3:125678407 NA -0.83 -7.4 -0.38 1.15e-12 Depression; LUSC cis rs17401966 0.540 rs4846216 chr1:10447792 A/T cg19773385 chr1:10388646 KIF1B 0.37 6.42 0.33 4.78e-10 Hepatocellular carcinoma; LUSC cis rs516243 0.688 rs284312 chr1:10737226 C/T cg02903756 chr1:10750680 CASZ1 -0.46 -8.05 -0.4 1.45e-14 Migraine - clinic-based; LUSC cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg08807101 chr21:30365312 RNF160 -0.69 -11.94 -0.55 1.28e-27 Dental caries; LUSC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg11890956 chr21:40555474 PSMG1 1.02 20.09 0.74 2.04e-59 Cognitive function; LUSC cis rs10791097 0.694 rs4457753 chr11:130755575 A/G cg12179176 chr11:130786555 SNX19 0.85 14.77 0.63 2.38e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2273669 0.667 rs3734649 chr6:109294752 C/T cg05315195 chr6:109294784 ARMC2 -0.58 -6.44 -0.33 4.09e-10 Prostate cancer; LUSC cis rs1981331 1.000 rs75843712 chr21:47976115 A/G cg17243659 chr21:48055224 PRMT2 0.86 6.21 0.32 1.61e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC trans rs412658 0.704 rs8105767 chr19:22215441 A/G cg05197062 chr11:11642011 GALNTL4 -0.41 -6.02 -0.31 4.6e-9 Telomere length; LUSC cis rs11098499 0.954 rs6846442 chr4:120326323 G/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs11105298 0.891 rs10858881 chr12:89891474 T/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -7.72 -0.39 1.38e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11644478 chr21:40555479 PSMG1 0.96 19.12 0.72 1.4e-55 Cognitive function; LUSC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -7.01 -0.36 1.29e-11 Cystic fibrosis severity; LUSC cis rs372883 0.600 rs407712 chr21:30722531 G/A cg08807101 chr21:30365312 RNF160 -0.71 -11.22 -0.52 5.45e-25 Pancreatic cancer; LUSC cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg27446573 chr6:127587934 RNF146 0.84 13.51 0.59 1.72e-33 Breast cancer; LUSC cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg07606381 chr6:8435919 SLC35B3 0.72 12.3 0.56 6.22e-29 Motion sickness; LUSC cis rs9325144 0.560 rs61929893 chr12:38653366 G/A cg13010199 chr12:38710504 ALG10B -0.51 -7.68 -0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs73001065 0.792 rs16996148 chr19:19658472 G/T cg03709012 chr19:19516395 GATAD2A 0.82 6.94 0.35 2.08e-11 LDL cholesterol; LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg05896524 chr21:47604654 C21orf56 0.51 7.75 0.39 1.13e-13 Testicular germ cell tumor; LUSC cis rs7760949 0.889 rs9396262 chr6:13927418 C/T cg27413430 chr6:13925136 RNF182 0.61 8.89 0.44 3.81e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs7917772 0.582 rs10786698 chr10:104378750 G/A cg22532475 chr10:104410764 TRIM8 -0.26 -6.07 -0.32 3.46e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9527 0.545 rs7095304 chr10:104954795 G/A cg05855489 chr10:104503620 C10orf26 0.5 7.7 0.39 1.59e-13 Arsenic metabolism; LUSC cis rs9309473 0.607 rs7567017 chr2:73596270 C/T cg20560298 chr2:73613845 ALMS1 -0.57 -8.47 -0.42 8.05e-16 Metabolite levels; LUSC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08109568 chr15:31115862 NA -0.51 -7.29 -0.37 2.22e-12 Huntington's disease progression; LUSC cis rs6500395 1.000 rs9933976 chr16:48590145 A/G cg04672837 chr16:48644449 N4BP1 0.43 6.34 0.33 7.56e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg06263672 chr7:65235340 NA -0.44 -6.41 -0.33 4.82e-10 Calcium levels; LUSC cis rs72960926 0.744 rs1931272 chr6:74950681 C/T cg03266952 chr6:74778945 NA -0.84 -6.98 -0.36 1.57e-11 Metabolite levels (MHPG); LUSC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg06634786 chr22:41940651 POLR3H 0.52 5.94 0.31 7.26e-9 Vitiligo; LUSC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg04111992 chr7:158790115 NA -0.49 -7.58 -0.38 3.41e-13 Facial morphology (factor 20); LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg18402987 chr7:1209562 NA 0.73 7.92 0.4 3.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs748404 0.604 rs2278857 chr15:43632549 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.44 6.03 0.31 4.33e-9 Lung cancer; LUSC cis rs3824867 0.879 rs10769267 chr11:47460098 C/T cg20307385 chr11:47447363 PSMC3 0.65 9.66 0.47 1.27e-19 Mean corpuscular hemoglobin; LUSC cis rs727505 0.821 rs67167896 chr7:124614127 T/C cg23710748 chr7:124431027 NA -0.37 -6.54 -0.34 2.27e-10 Lewy body disease; LUSC cis rs12368653 0.666 rs799267 chr12:58113158 C/T cg18357645 chr12:58087776 OS9 0.41 6.22 0.32 1.49e-9 Multiple sclerosis; LUSC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18099408 chr3:52552593 STAB1 -0.42 -7.24 -0.37 3.2e-12 Electroencephalogram traits; LUSC cis rs11608355 0.545 rs2302704 chr12:109898797 A/G cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg12311346 chr5:56204834 C5orf35 -0.9 -13.21 -0.59 2.44e-32 Initial pursuit acceleration; LUSC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg09021430 chr5:549028 NA -0.57 -7.76 -0.39 1.04e-13 Obesity-related traits; LUSC cis rs77633900 0.614 rs2459360 chr15:76868664 C/T cg21673338 chr15:77095150 SCAPER -0.73 -7.19 -0.37 4.22e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs9388451 0.536 rs34725880 chr6:126155237 A/G cg05901451 chr6:126070800 HEY2 -0.67 -10.33 -0.49 6.6e-22 Brugada syndrome; LUSC trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg03929089 chr4:120376271 NA -0.79 -10.1 -0.48 4.02e-21 Coronary artery disease; LUSC trans rs9329221 0.527 rs6989657 chr8:10330873 C/G cg06636001 chr8:8085503 FLJ10661 0.45 6.37 0.33 6.28e-10 Neuroticism; LUSC cis rs17767294 0.541 rs72845050 chr6:27610070 A/C cg08851530 chr6:28072375 NA 0.9 6.21 0.32 1.61e-9 Parkinson's disease; LUSC trans rs8073060 0.586 rs4796098 chr17:33913436 T/C cg19694781 chr19:47549865 TMEM160 1.15 18.32 0.71 2.27e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs12677618 1.000 rs10092931 chr8:142307201 A/G cg07140289 chr8:142299684 NA 0.35 5.74 0.3 2.15e-8 Plateletcrit; LUSC cis rs8126001 0.573 rs7271530 chr20:62727915 A/G cg03642690 chr20:62727907 OPRL1 0.32 5.69 0.3 2.85e-8 Pulse pressure;Mean corpuscular volume; LUSC cis rs1372520 0.808 rs1372518 chr4:90757294 A/C cg01966878 chr4:90757139 SNCA -0.43 -6.16 -0.32 2.05e-9 Neuroticism; LUSC cis rs7523273 0.606 rs1962149 chr1:207956559 G/A cg22525895 chr1:207977042 MIR29B2 -0.39 -6.12 -0.32 2.61e-9 Schizophrenia; LUSC cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg24088639 chr11:34937564 PDHX;APIP -0.49 -7.2 -0.37 3.92e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg26890010 chr1:70876953 CTH 0.43 6.21 0.32 1.58e-9 Triglycerides; LUSC cis rs6693567 0.545 rs1260403 chr1:150303666 A/G cg15654264 chr1:150340011 RPRD2 0.45 7.33 0.37 1.8e-12 Migraine; LUSC cis rs3857536 0.813 rs9363554 chr6:66930183 A/G cg07460842 chr6:66804631 NA -0.47 -6.49 -0.33 3.18e-10 Blood trace element (Cu levels); LUSC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg16584290 chr5:462447 EXOC3 -0.34 -5.81 -0.3 1.46e-8 Cystic fibrosis severity; LUSC trans rs12310956 0.532 rs1525897 chr12:33941033 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.36 0.42 1.73e-15 Morning vs. evening chronotype; LUSC cis rs559928 0.606 rs17773078 chr11:63906224 G/A cg05555928 chr11:63887634 MACROD1 -0.48 -6.09 -0.32 3.08e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs3960554 0.741 rs10232162 chr7:75702505 C/T cg17325771 chr7:75508891 RHBDD2 -0.4 -5.68 -0.3 2.87e-8 Eotaxin levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15283028 chr22:41601160 L3MBTL2 0.45 6.19 0.32 1.8e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.887 rs736031 chr20:34048625 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.72 -0.35 7.94e-11 Total cholesterol levels; LUSC cis rs874628 0.686 rs11666281 chr19:18234588 C/T cg00493341 chr19:18228948 MAST3 0.47 6.31 0.33 8.81e-10 Multiple sclerosis; LUSC cis rs7605827 0.930 rs6720900 chr2:15688281 T/C cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.32e-17 Educational attainment (years of education); LUSC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg22823121 chr1:150693482 HORMAD1 0.47 6.71 0.34 8.59e-11 Melanoma; LUSC cis rs7089973 0.604 rs7897937 chr10:116591318 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.21 0.45 3.72e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg06637938 chr14:75390232 RPS6KL1 0.54 8.78 0.43 8.47e-17 Coronary artery disease; LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg09877947 chr5:131593287 PDLIM4 0.45 7.07 0.36 8.83e-12 Breast cancer; LUSC trans rs61931739 0.500 rs10844829 chr12:34304916 G/T cg13010199 chr12:38710504 ALG10B 0.54 8.44 0.42 9.47e-16 Morning vs. evening chronotype; LUSC cis rs2073300 0.609 rs6137937 chr20:23385419 G/A cg12062639 chr20:23401060 NAPB 0.94 8.24 0.41 3.94e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg18876405 chr7:65276391 NA 0.54 8.62 0.43 2.7e-16 Aortic root size; LUSC cis rs2762353 0.935 rs1183200 chr6:25818646 G/C cg12310025 chr6:25882481 NA -0.45 -7.82 -0.39 7.19e-14 Blood metabolite levels; LUSC cis rs4851254 0.660 rs60697219 chr2:100699507 G/A cg22139774 chr2:100720529 AFF3 -0.43 -5.75 -0.3 1.99e-8 Intelligence (multi-trait analysis); LUSC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg03909863 chr11:638404 DRD4 -0.37 -5.7 -0.3 2.66e-8 Systemic lupus erythematosus; LUSC cis rs11098499 0.779 rs6815934 chr4:120267310 T/C cg24375607 chr4:120327624 NA 0.69 10.92 0.51 6.06e-24 Corneal astigmatism; LUSC cis rs11758351 1.000 rs3734530 chr6:26195408 G/C cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs2932538 0.922 rs6698030 chr1:113138318 G/A cg22162597 chr1:113214053 CAPZA1 0.7 10.06 0.48 5.71e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg01570182 chr17:44337453 NA 0.69 10.39 0.49 4.39e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9653442 0.522 rs4851274 chr2:100870862 T/C cg22139774 chr2:100720529 AFF3 -0.37 -6.14 -0.32 2.39e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg23283495 chr1:209979779 IRF6 0.67 7.92 0.4 3.5e-14 Cleft lip with or without cleft palate; LUSC cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg02527881 chr3:46936655 PTH1R -0.66 -12.03 -0.55 6.31e-28 Birth weight; LUSC cis rs11785693 0.862 rs6994150 chr8:4996630 T/G cg26367366 chr8:4980734 NA 0.71 8.43 0.42 1.02e-15 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg09877947 chr5:131593287 PDLIM4 0.42 6.98 0.36 1.57e-11 Blood metabolite levels; LUSC cis rs6975373 0.730 rs1009528 chr7:4456304 G/T cg10785373 chr7:4456119 NA -0.6 -5.7 -0.3 2.58e-8 Borderline personality disorder; LUSC cis rs7617480 0.648 rs6801211 chr3:48774420 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.65 10.1 0.48 4.12e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg20887711 chr4:1340912 KIAA1530 0.47 7.17 0.37 4.96e-12 Obesity-related traits; LUSC cis rs9902453 0.845 rs12602426 chr17:28158815 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.21 0.45 3.83e-18 Coffee consumption (cups per day); LUSC cis rs4423214 0.840 rs1792235 chr11:71181473 C/T cg05163923 chr11:71159392 DHCR7 -0.77 -10.04 -0.48 6.5e-21 Vitamin D levels; LUSC cis rs7474896 0.515 rs624359 chr10:38299132 T/C cg25427524 chr10:38739819 LOC399744 0.43 5.75 0.3 2e-8 Obesity (extreme); LUSC trans rs7507204 0.530 rs4807469 chr19:3443382 G/C cg08382705 chr11:45687319 CHST1 -0.49 -7.76 -0.39 1.04e-13 Height; LUSC trans rs9747201 1.000 rs9303020 chr17:80163247 C/T cg07393940 chr7:158741817 NA 0.51 8.42 0.42 1.13e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.11 -0.58 5.82e-32 Platelet count; LUSC cis rs68092024 0.731 rs793480 chr3:99488364 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 6.34 0.33 7.66e-10 Cleft lip with or without cleft palate; LUSC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg19346786 chr7:2764209 NA -0.39 -6.85 -0.35 3.63e-11 Height; LUSC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7169223 0.653 rs1564499 chr15:79084808 C/T cg21242079 chr15:79101063 ADAMTS7 -0.39 -6.06 -0.31 3.73e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6987853 0.933 rs2974339 chr8:42397529 T/C cg09913449 chr8:42400586 C8orf40 0.49 8.26 0.41 3.35e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs4988958 0.565 rs6732138 chr2:103009662 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.54e-12 Asthma (childhood onset); LUSC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg00310523 chr12:86230176 RASSF9 0.46 8.5 0.42 6.35e-16 Major depressive disorder; LUSC cis rs2200578 1.000 rs60025964 chr2:99880577 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.53 6.19 0.32 1.72e-9 IgG glycosylation; LUSC cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg22349387 chr12:9600060 DDX12 -0.44 -7.04 -0.36 1.12e-11 Breast size; LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs9790314 0.875 rs163327 chr3:161062724 A/G cg03342759 chr3:160939853 NMD3 -0.47 -7.77 -0.39 9.72e-14 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg07507251 chr3:52567010 NT5DC2 0.33 6.61 0.34 1.49e-10 Bipolar disorder; LUSC cis rs826838 0.935 rs10875816 chr12:38955014 C/A cg13010199 chr12:38710504 ALG10B 0.68 11.24 0.52 4.31e-25 Heart rate; LUSC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg01503450 chr10:980765 NA -0.39 -5.72 -0.3 2.34e-8 Eosinophil percentage of granulocytes; LUSC cis rs870825 0.655 rs67798981 chr4:185619567 A/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg18538332 chr22:24372958 LOC391322 -0.47 -8.37 -0.42 1.62e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4654899 1.000 rs7537072 chr1:21434533 T/C cg01072550 chr1:21505969 NA -0.51 -7.79 -0.39 8.71e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg10862848 chr6:42927986 GNMT -0.27 -6.34 -0.33 7.6e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg14773178 chr5:1868261 NA 0.31 5.69 0.3 2.74e-8 Cardiovascular disease risk factors; LUSC cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg06454157 chr6:167490870 NA -0.24 -6.04 -0.31 4.19e-9 Crohn's disease; LUSC cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg05855489 chr10:104503620 C10orf26 0.6 9.76 0.47 5.86e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1348850 0.958 rs1548067 chr2:178462914 C/T cg22681709 chr2:178499509 PDE11A -0.45 -8.12 -0.41 9.28e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.98 0.66 4.1e-43 Platelet count; LUSC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg02269571 chr22:50332266 NA 0.59 8.71 0.43 1.44e-16 Schizophrenia; LUSC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg02569458 chr12:86230093 RASSF9 0.48 7.66 0.39 2.03e-13 Major depressive disorder; LUSC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg17509989 chr5:176798049 RGS14 -0.85 -14.33 -0.62 1.18e-36 Hemoglobin concentration;Hematocrit; LUSC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.65 0.47 1.38e-19 Bipolar disorder; LUSC cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg26384229 chr12:38710491 ALG10B 0.87 14.25 0.61 2.49e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs2274273 1.000 rs10149435 chr14:55627489 C/T cg04306507 chr14:55594613 LGALS3 0.54 11.89 0.55 2.02e-27 Protein biomarker; LUSC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg27411982 chr8:10470053 RP1L1 -0.45 -7.2 -0.37 4.06e-12 Systolic blood pressure; LUSC cis rs6542838 0.641 rs6760065 chr2:99486318 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.08 -0.32 3.22e-9 Fear of minor pain; LUSC cis rs35146811 0.735 rs858506 chr7:99820050 T/C cg13334819 chr7:99746414 C7orf59 0.49 6.5 0.34 2.96e-10 Coronary artery disease; LUSC cis rs6545883 0.965 rs1992765 chr2:61751333 A/G cg15711740 chr2:61764176 XPO1 -0.5 -7.93 -0.4 3.26e-14 Tuberculosis; LUSC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg05585544 chr11:47624801 NA -0.42 -7.39 -0.37 1.21e-12 Subjective well-being; LUSC trans rs7647973 0.626 rs9835157 chr3:49797769 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.6 7.1 0.36 7.44e-12 Menarche (age at onset); LUSC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg13319975 chr6:146136371 FBXO30 -0.7 -10.73 -0.51 2.91e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs7789940 1.000 rs76024966 chr7:75995021 C/T cg10167463 chr7:75959203 YWHAG -0.66 -9.96 -0.48 1.24e-20 Multiple sclerosis; LUSC cis rs6840360 0.593 rs867800 chr4:152691470 T/C cg22705602 chr4:152727874 NA -0.39 -8.54 -0.42 4.8e-16 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.629 rs12617779 chr2:100937707 G/A cg12002119 chr2:101014098 CHST10 0.35 5.81 0.3 1.5e-8 Intelligence (multi-trait analysis); LUSC cis rs9311676 0.632 rs11130631 chr3:58366128 G/C cg26110898 chr3:58419937 PDHB 0.44 7.22 0.37 3.62e-12 Systemic lupus erythematosus; LUSC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.78e-19 Developmental language disorder (linguistic errors); LUSC cis rs4356932 1.000 rs6846814 chr4:76952288 A/G cg00809888 chr4:76862425 NAAA 0.35 5.78 0.3 1.69e-8 Blood protein levels; LUSC cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.66e-15 Axial length; LUSC cis rs950169 0.845 rs4502182 chr15:84923520 A/G cg17507749 chr15:85114479 UBE2QP1 0.67 8.52 0.42 5.39e-16 Schizophrenia; LUSC cis rs61990749 0.597 rs176946 chr14:78178439 C/T cg23188588 chr14:78226832 SNW1;C14orf178 0.51 5.68 0.3 2.9e-8 Fibroblast growth factor basic levels; LUSC cis rs317689 0.690 rs604168 chr12:69671158 C/T cg20891283 chr12:69753455 YEATS4 0.44 6.02 0.31 4.53e-9 Response to diuretic therapy; LUSC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg16414030 chr3:133502952 NA 0.35 5.77 0.3 1.86e-8 Iron status biomarkers; LUSC cis rs1801251 0.835 rs1446310 chr2:233683245 G/C cg25237894 chr2:233734115 C2orf82 -0.34 -6.17 -0.32 1.99e-9 Coronary artery disease; LUSC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg02221750 chr19:17393354 ANKLE1 -0.89 -13.67 -0.6 4.45e-34 Systemic lupus erythematosus; LUSC cis rs600231 0.665 rs1784858 chr11:65222952 T/C cg21890820 chr11:65308645 LTBP3 0.5 7.44 0.38 8.38e-13 Bone mineral density; LUSC cis rs11155671 0.530 rs9371223 chr6:150214806 T/C cg13206674 chr6:150067644 NUP43 0.43 6.45 0.33 4.02e-10 Testicular germ cell tumor; LUSC cis rs9341835 0.510 rs2250179 chr6:64174559 T/G cg03326410 chr6:64151739 NA -0.36 -5.91 -0.31 8.32e-9 Schizophrenia; LUSC cis rs1506636 1.000 rs619575 chr7:123393460 C/T cg03229431 chr7:123269106 ASB15 -0.58 -9.33 -0.45 1.5e-18 Plateletcrit;Platelet count; LUSC cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.42 -0.46 7.51e-19 Chronic sinus infection; LUSC cis rs4919694 1.000 rs77827514 chr10:104822009 C/T cg04362960 chr10:104952993 NT5C2 1.18 13.92 0.61 4.83e-35 Arsenic metabolism; LUSC trans rs9975851 0.663 rs219685 chr21:27734660 A/G cg13892514 chr2:241853394 NA 0.34 5.96 0.31 6.39e-9 Airflow obstruction; LUSC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg03676636 chr4:99064102 C4orf37 0.37 7.68 0.39 1.8e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1358748 0.522 rs1321153 chr1:67584824 T/C cg02640540 chr1:67518911 SLC35D1 0.67 6.53 0.34 2.5e-10 Tuberculosis; LUSC cis rs16867335 1.000 rs11899423 chr2:181483750 C/A cg23363182 chr2:181467187 NA -0.46 -6.1 -0.32 2.97e-9 Survival in rectal cancer; LUSC cis rs9925964 0.967 rs889548 chr16:31137712 A/G cg02466173 chr16:30829666 NA -0.34 -6.18 -0.32 1.86e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6121246 0.529 rs6060142 chr20:30178028 A/G cg18721089 chr20:30220636 NA -0.43 -6.93 -0.35 2.24e-11 Mean corpuscular hemoglobin; LUSC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg14552801 chr7:65878734 NA 0.45 6.53 0.34 2.5e-10 Aortic root size; LUSC cis rs2067615 0.542 rs11113120 chr12:107203460 T/C cg15890332 chr12:107067104 RFX4 0.34 6.21 0.32 1.61e-9 Heart rate; LUSC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg19468946 chr17:37922297 IKZF3 -0.44 -6.91 -0.35 2.5e-11 Self-reported allergy; LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg00945038 chr17:61921165 SMARCD2 0.53 8.91 0.44 3.33e-17 Prudent dietary pattern; LUSC cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg08999081 chr20:33150536 PIGU 0.43 7.98 0.4 2.4e-14 Coronary artery disease; LUSC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1322512 0.874 rs2758802 chr6:152952542 A/G cg27316956 chr6:152958899 SYNE1 -0.36 -6.18 -0.32 1.82e-9 Tonometry; LUSC cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg11266682 chr4:10021025 SLC2A9 0.43 7.41 0.38 1.03e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1371867 0.810 rs3020182 chr8:101233008 T/C cg00191853 chr8:101177733 SPAG1 0.4 6.47 0.33 3.47e-10 Atrioventricular conduction; LUSC cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.31e-11 Schizophrenia; LUSC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.41 0.33 4.95e-10 Lung cancer; LUSC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.72 0.39 1.32e-13 Total body bone mineral density; LUSC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12667521 chr19:29218732 NA 0.61 8.78 0.43 8.57e-17 Methadone dose in opioid dependence; LUSC cis rs4343996 0.720 rs2178630 chr7:3492208 T/C cg21248987 chr7:3385318 SDK1 0.35 5.75 0.3 2.07e-8 Motion sickness; LUSC cis rs10927875 0.619 rs28537253 chr1:16148600 A/C cg21385522 chr1:16154831 NA -0.65 -10.75 -0.51 2.47e-23 Dilated cardiomyopathy; LUSC cis rs7119 0.700 rs4886519 chr15:77893885 A/G cg27398640 chr15:77910606 LINGO1 0.37 8.75 0.43 1.08e-16 Type 2 diabetes; LUSC cis rs1506636 1.000 rs600774 chr7:123397831 C/T cg03229431 chr7:123269106 ASB15 0.61 9.84 0.47 3.12e-20 Plateletcrit;Platelet count; LUSC cis rs7824557 0.767 rs10104728 chr8:11171300 A/G cg21775007 chr8:11205619 TDH 0.75 12.44 0.56 1.94e-29 Retinal vascular caliber; LUSC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg22823121 chr1:150693482 HORMAD1 0.49 7.0 0.36 1.42e-11 Melanoma; LUSC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg03351412 chr1:154909251 PMVK 0.55 8.7 0.43 1.52e-16 Prostate cancer; LUSC cis rs2607426 0.681 rs2303723 chr19:41230995 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.92 7.08 0.36 8.81e-12 Blood protein levels; LUSC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg26408565 chr15:76604113 ETFA -0.48 -7.83 -0.39 6.69e-14 Blood metabolite levels; LUSC cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.81 0.43 6.77e-17 Axial length; LUSC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.12 15.13 0.64 9.18e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9921338 0.961 rs72773830 chr16:11412823 G/C cg00044050 chr16:11439710 C16orf75 -0.5 -6.75 -0.35 6.64e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 7.64 0.39 2.28e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg12463550 chr7:65579703 CRCP -0.56 -8.33 -0.41 2.14e-15 Aortic root size; LUSC cis rs7589342 0.660 rs11124058 chr2:106400749 A/G cg14210321 chr2:106509881 NCK2 -0.44 -6.09 -0.32 3.06e-9 Addiction; LUSC cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg11752832 chr7:134001865 SLC35B4 -0.48 -7.12 -0.36 6.49e-12 Mean platelet volume; LUSC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg08680598 chr22:49984980 NA -0.35 -6.52 -0.34 2.53e-10 Monocyte count;Monocyte percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02964845 chr11:64885336 ZNHIT2 -0.42 -6.14 -0.32 2.35e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11822910 1.000 rs11822910 chr11:57195917 G/A cg00522883 chr11:57194120 SLC43A3 0.44 6.37 0.33 6.21e-10 Platelet distribution width; LUSC cis rs62400317 0.859 rs72869118 chr6:45064626 T/C cg18551225 chr6:44695536 NA -0.42 -6.82 -0.35 4.17e-11 Total body bone mineral density; LUSC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg06637938 chr14:75390232 RPS6KL1 0.51 7.87 0.4 5.01e-14 Height; LUSC cis rs6456156 0.742 rs3093026 chr6:167532690 A/G cg07741184 chr6:167504864 NA 0.32 5.76 0.3 1.87e-8 Primary biliary cholangitis; LUSC cis rs12200560 0.505 rs1334318 chr6:97079610 A/G cg06623918 chr6:96969491 KIAA0776 -0.48 -6.94 -0.36 2.02e-11 Coronary heart disease; LUSC cis rs10754283 0.967 rs10737707 chr1:90119304 A/G cg21401794 chr1:90099060 LRRC8C 0.61 8.78 0.43 8.66e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs10751667 0.666 rs6597962 chr11:976351 C/T ch.11.42038R chr11:967971 AP2A2 0.42 6.11 0.32 2.78e-9 Alzheimer's disease (late onset); LUSC cis rs6582630 0.576 rs2387837 chr12:38403164 G/T cg13010199 chr12:38710504 ALG10B -0.45 -6.7 -0.34 8.84e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg18225595 chr11:63971243 STIP1 0.51 6.31 0.33 8.93e-10 Mean platelet volume; LUSC cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.94 0.4 3.18e-14 Parkinson's disease; LUSC cis rs600626 0.529 rs2008476 chr11:75470813 C/T cg24262691 chr11:75473276 NA 0.51 6.64 0.34 1.3100000000000001e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs55665837 1.000 rs10832264 chr11:14459982 T/A cg05501817 chr11:14380813 RRAS2 -0.41 -6.51 -0.34 2.72e-10 Vitamin D levels; LUSC cis rs7267979 0.932 rs2387891 chr20:25470328 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.25 0.71 4.19e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7089973 0.523 rs6585311 chr10:116733575 T/C cg23260525 chr10:116636907 FAM160B1 0.3 5.78 0.3 1.73e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg24881330 chr22:46731750 TRMU 0.84 7.3 0.37 2.11e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg20476274 chr7:133979776 SLC35B4 0.79 13.93 0.61 4.16e-35 Mean platelet volume; LUSC cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg07424592 chr7:64974309 NA 0.67 5.97 0.31 6.18e-9 Diabetic kidney disease; LUSC cis rs9640161 0.830 rs35840727 chr7:150063204 A/G cg17279839 chr7:150038598 RARRES2 0.4 6.13 0.32 2.46e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs2281845 0.859 rs4915217 chr1:201077470 T/A cg22815214 chr1:201083145 CACNA1S 0.53 9.17 0.45 5.08e-18 Permanent tooth development; LUSC cis rs2288073 0.619 rs6713263 chr2:24375463 A/G cg06627628 chr2:24431161 ITSN2 -0.47 -6.8 -0.35 4.87e-11 Venous thromboembolism (SNP x SNP interaction); LUSC trans rs61931739 0.500 rs11053271 chr12:34545407 C/A cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.43 -0.46 6.97e-19 Chronic sinus infection; LUSC cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg05347473 chr6:146136440 FBXO30 -0.51 -8.74 -0.43 1.19e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg22029157 chr1:209979665 IRF6 0.8 10.25 0.49 1.27e-21 Cleft lip with or without cleft palate; LUSC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.02 -0.31 4.55e-9 Total body bone mineral density; LUSC cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg09035930 chr12:129282057 SLC15A4 -0.6 -9.98 -0.48 1.06e-20 Systemic lupus erythematosus; LUSC cis rs2742234 0.541 rs12416428 chr10:43708998 G/A cg02780029 chr10:43622663 RET 0.34 5.66 0.3 3.23e-8 Hirschsprung disease; LUSC cis rs9472414 0.771 rs1935549 chr6:44763188 C/T cg20913747 chr6:44695427 NA 0.41 5.92 0.31 7.92e-9 Height; LUSC trans rs11671005 0.504 rs7257669 chr19:59064939 T/C cg22037779 chr5:139682734 PFDN1 -0.56 -7.19 -0.37 4.21e-12 Mean platelet volume; LUSC cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg00999904 chr2:3704751 ALLC 0.53 8.79 0.43 7.76e-17 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7586879 0.964 rs4077679 chr2:25122852 T/C cg01884057 chr2:25150051 NA 0.42 9.1 0.45 8.06e-18 Body mass index; LUSC trans rs17266958 1.000 rs62576991 chr9:83299840 C/T cg01905489 chr1:26616534 UBXN11 -0.51 -5.97 -0.31 6.06e-9 Preschool internalizing problems; LUSC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.17 -0.32 1.96e-9 Alzheimer's disease (late onset); LUSC cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg07606381 chr6:8435919 SLC35B3 0.75 12.45 0.56 1.73e-29 Motion sickness; LUSC cis rs7296418 0.630 rs11608305 chr12:123791165 C/G cg05973401 chr12:123451056 ABCB9 0.52 7.54 0.38 4.47e-13 Platelet count; LUSC cis rs9486719 0.894 rs34826652 chr6:96899085 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg03709012 chr19:19516395 GATAD2A 0.76 11.7 0.54 1e-26 Tonsillectomy; LUSC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg20276088 chr3:133502917 NA -0.42 -6.13 -0.32 2.45e-9 Iron status biomarkers; LUSC cis rs4268898 0.931 rs2551121 chr2:24539967 T/C cg06627628 chr2:24431161 ITSN2 -0.61 -9.0 -0.44 1.75e-17 Asthma; LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg23758822 chr17:41437982 NA 1.06 20.2 0.74 7.16e-60 Menopause (age at onset); LUSC cis rs6060987 1 rs6060987 chr20:30427077 T/A cg13852791 chr20:30311386 BCL2L1 0.82 10.81 0.51 1.42e-23 Mean corpuscular volume; LUSC cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs1577917 1.000 rs16876529 chr6:86591202 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.2 -0.41 5.06e-15 Response to antipsychotic treatment; LUSC cis rs11209002 1.000 rs2863202 chr1:67584335 T/C cg02640540 chr1:67518911 SLC35D1 0.68 7.37 0.37 1.4e-12 Crohn's disease; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg13453750 chr1:205783389 SLC41A1 -0.33 -6.41 -0.33 5.09e-10 Menarche (age at onset); LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg01802117 chr1:53393560 SCP2 0.39 6.45 0.33 3.85e-10 Monocyte count; LUSC cis rs76935404 0.899 rs73034465 chr19:41419075 A/G cg04176888 chr19:41596066 CYP2A13 0.39 6.02 0.31 4.51e-9 nicotine metabolite ratio in current smokers; LUSC cis rs295140 1.000 rs7559005 chr2:201161371 C/T cg04283868 chr2:201171347 SPATS2L 0.43 6.58 0.34 1.83e-10 QT interval; LUSC cis rs12711979 0.740 rs6711964 chr2:3820916 A/T cg17052675 chr2:3827356 NA -0.58 -11.38 -0.53 1.42e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs6500602 1.000 rs6500602 chr16:4497451 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 6.35 0.33 7.14e-10 Schizophrenia; LUSC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg08508325 chr11:3079039 CARS -0.54 -13.71 -0.6 3.07e-34 Longevity; LUSC trans rs62458065 0.850 rs7808992 chr7:32470677 C/T cg00845942 chr12:64062724 DPY19L2 -0.53 -6.23 -0.32 1.42e-9 Metabolite levels (HVA/MHPG ratio); LUSC trans rs11098499 0.569 rs55845118 chr4:120290913 T/C cg25214090 chr10:38739885 LOC399744 0.49 7.53 0.38 4.82e-13 Corneal astigmatism; LUSC cis rs7089973 0.932 rs17794346 chr10:116643095 C/T cg23260525 chr10:116636907 FAM160B1 -0.34 -6.54 -0.34 2.31e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08704250 chr15:31115839 NA 0.41 6.25 0.32 1.28e-9 Huntington's disease progression; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg18404041 chr3:52824283 ITIH1 0.59 11.57 0.53 2.89e-26 Bipolar disorder; LUSC cis rs240764 0.658 rs12213201 chr6:101176285 C/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.44 -0.33 4.08e-10 Neuroticism; LUSC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg08280861 chr8:58055591 NA 0.54 5.94 0.31 6.98e-9 Developmental language disorder (linguistic errors); LUSC cis rs12210905 0.541 rs62617138 chr6:27463766 C/A cg08851530 chr6:28072375 NA 0.93 5.71 0.3 2.47e-8 Hip circumference adjusted for BMI; LUSC cis rs1577917 0.740 rs9344533 chr6:86236188 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 7.41 0.38 1.07e-12 Response to antipsychotic treatment; LUSC cis rs524023 0.914 rs80841 chr11:64437490 T/C cg07220939 chr11:64358617 SLC22A12 -0.22 -5.71 -0.3 2.56e-8 Urate levels in obese individuals; LUSC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg09034736 chr1:150693464 HORMAD1 0.53 7.62 0.38 2.72e-13 Tonsillectomy; LUSC cis rs988712 0.705 rs1829469 chr11:27730556 A/G cg10635145 chr11:27742435 BDNF -0.48 -6.35 -0.33 7.05e-10 Obesity; LUSC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg03709012 chr19:19516395 GATAD2A 0.87 14.79 0.63 1.95e-38 Tonsillectomy; LUSC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg05368731 chr17:41323189 NBR1 0.91 15.38 0.64 9.64e-41 Menopause (age at onset); LUSC cis rs4073221 0.929 rs7371812 chr3:18281071 C/T cg07694806 chr3:18168406 NA 0.55 5.65 0.3 3.38e-8 Parkinson's disease; LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs13067593 1.000 rs67563589 chr3:188564574 G/C cg17809494 chr3:188572244 LPP 0.45 6.26 0.32 1.18e-9 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs9788682 1.000 rs57064725 chr15:78833036 C/A cg24631222 chr15:78858424 CHRNA5 0.81 11.54 0.53 3.89e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg12311346 chr5:56204834 C5orf35 -0.65 -10.16 -0.49 2.62e-21 Coronary artery disease; LUSC cis rs561341 1.000 rs72821952 chr17:30248133 T/A cg00745463 chr17:30367425 LRRC37B -0.83 -9.07 -0.44 1.01e-17 Hip circumference adjusted for BMI; LUSC cis rs9399135 0.967 rs2150681 chr6:135375232 A/G cg22676075 chr6:135203613 NA -0.47 -7.45 -0.38 7.86e-13 Red blood cell count; LUSC cis rs2404618 0.624 rs7012381 chr8:1475357 C/T cg13402656 chr8:1511478 DLGAP2 -0.57 -8.92 -0.44 3.21e-17 Lung cancer; LUSC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg05234568 chr11:5960015 NA -0.58 -9.56 -0.46 2.67e-19 DNA methylation (variation); LUSC cis rs709400 0.643 rs11621777 chr14:104072090 A/G cg24130564 chr14:104152367 KLC1 -0.48 -6.93 -0.35 2.14e-11 Body mass index; LUSC cis rs2050392 0.829 rs306589 chr10:30723831 A/G cg18806716 chr10:30721971 MAP3K8 -0.48 -8.01 -0.4 1.98e-14 Inflammatory bowel disease; LUSC cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg08999081 chr20:33150536 PIGU -0.52 -10.3 -0.49 8.66e-22 Glomerular filtration rate (creatinine); LUSC cis rs17270561 0.609 rs12192077 chr6:25732794 G/A cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.68 0.7 7.58e-50 Chronic sinus infection; LUSC cis rs9811920 0.809 rs6802817 chr3:99779264 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.35 -6.52 -0.34 2.6e-10 Axial length; LUSC cis rs57549656 0.799 rs28628309 chr19:2712586 T/G cg06609049 chr19:2785107 THOP1 0.49 6.39 0.33 5.45e-10 Schizophrenia; LUSC cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.21 0.69 5.93e-48 Chronic sinus infection; LUSC cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg06697600 chr4:7070879 GRPEL1 -0.4 -6.56 -0.34 2.09e-10 Monocyte percentage of white cells; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg13047869 chr3:10149882 C3orf24 0.56 7.89 0.4 4.32e-14 Alzheimer's disease; LUSC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg03806693 chr22:41940476 POLR3H -1.06 -15.56 -0.65 1.88e-41 Vitiligo; LUSC cis rs9814567 0.896 rs13089566 chr3:134349710 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 0.33 6.07 0.32 3.46e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1443512 0.812 rs1561987 chr12:54335268 C/T cg17410650 chr12:54324560 NA -0.57 -9.89 -0.48 2.18e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg17971929 chr21:40555470 PSMG1 0.77 12.62 0.57 3.88e-30 Cognitive function; LUSC cis rs1577917 0.958 rs36035797 chr6:86562880 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg03433033 chr1:76189801 ACADM 0.72 9.4 0.46 8.87e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.77 0.3 1.78e-8 Tonsillectomy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23918991 chr4:103749251 UBE2D3 -0.48 -6.08 -0.32 3.27e-9 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 9.96e-29 Motion sickness; LUSC cis rs9549260 0.755 rs58919811 chr13:41226485 A/C cg21288729 chr13:41239152 FOXO1 0.65 10.04 0.48 6.48e-21 Red blood cell count; LUSC cis rs7215564 0.908 rs34135683 chr17:78652903 G/T cg09596252 chr17:78655493 RPTOR 0.55 5.92 0.31 7.92e-9 Myopia (pathological); LUSC trans rs6598955 0.671 rs12354062 chr1:26608761 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.62 -0.43 2.82e-16 Obesity-related traits; LUSC cis rs1461503 0.966 rs10892936 chr11:122841720 G/A cg27398637 chr11:122830231 C11orf63 -0.41 -6.52 -0.34 2.55e-10 Menarche (age at onset); LUSC cis rs11105298 0.891 rs10858896 chr12:89920184 C/T cg00757033 chr12:89920650 WDR51B 0.59 10.22 0.49 1.69e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9326248 0.581 rs7121898 chr11:116796846 A/T cg26566898 chr11:117069891 TAGLN 0.38 7.24 0.37 3.1e-12 Blood protein levels; LUSC cis rs644148 0.738 rs2686767 chr19:44995037 G/C cg15540054 chr19:45004280 ZNF180 -0.5 -6.99 -0.36 1.46e-11 Personality dimensions; LUSC cis rs9814567 1.000 rs9871305 chr3:134213538 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.96 -0.61 3.22e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs868036 0.681 rs28688285 chr15:68110297 T/C cg05925327 chr15:68127851 NA -0.47 -6.87 -0.35 3.16e-11 Restless legs syndrome; LUSC cis rs4953076 0.573 rs920519 chr2:44452344 T/C cg04920474 chr2:44395004 PPM1B 0.6 7.85 0.39 5.88e-14 Height; LUSC cis rs6750047 1.000 rs6750047 chr2:38276549 A/G cg07380506 chr2:38303506 CYP1B1 0.47 6.6 0.34 1.64e-10 Cutaneous malignant melanoma;Melanoma; LUSC trans rs4689388 0.926 rs11732178 chr4:6292643 G/C cg17567195 chr5:167378696 ODZ2 -0.38 -6.08 -0.32 3.27e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12474201 0.928 rs7594523 chr2:46935791 G/C cg06386533 chr2:46925753 SOCS5 0.75 11.33 0.53 2.07e-25 Height; LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg06873352 chr17:61820015 STRADA 0.7 12.47 0.56 1.42e-29 Prudent dietary pattern; LUSC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg25036284 chr2:26402008 FAM59B -0.68 -9.47 -0.46 5.29e-19 Gut microbiome composition (summer); LUSC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg20203395 chr5:56204925 C5orf35 -0.74 -10.1 -0.48 4.21e-21 Initial pursuit acceleration; LUSC cis rs12479064 0.505 rs62153764 chr2:99818612 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.84 -10.14 -0.49 3.13e-21 Chronic sinus infection; LUSC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg08847533 chr14:75593920 NEK9 0.82 14.5 0.62 2.71e-37 Height; LUSC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.33e-8 Diabetic kidney disease; LUSC cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg22920501 chr2:26401640 FAM59B -0.72 -10.1 -0.48 4.05e-21 Gut microbiome composition (summer); LUSC trans rs330071 0.500 rs17662123 chr8:9246837 G/A cg08975724 chr8:8085496 FLJ10661 0.41 6.11 0.32 2.73e-9 Acne (severe); LUSC cis rs2708977 0.698 rs772159 chr2:97036439 G/A cg01950434 chr2:97203154 ARID5A -0.45 -5.99 -0.31 5.56e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs10979 0.964 rs35826562 chr6:143898672 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.79 -0.54 4.66e-27 Hypospadias; LUSC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg08132940 chr7:1081526 C7orf50 -0.48 -6.04 -0.31 4.02e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7944735 0.507 rs10742827 chr11:48102350 C/T cg03929089 chr4:120376271 NA 0.54 6.74 0.35 6.85e-11 Intraocular pressure; LUSC cis rs782590 0.935 rs782606 chr2:55886602 T/C cg18811423 chr2:55921094 PNPT1 0.87 15.49 0.65 3.75e-41 Metabolic syndrome; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs75229567 0.541 rs775443 chr12:70122623 C/T cg10114359 chr12:70132523 RAB3IP -0.86 -8.38 -0.42 1.52e-15 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs1775715 0.737 rs11008695 chr10:32216887 T/G cg26784012 chr10:32216390 ARHGAP12 0.44 7.44 0.38 8.73e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.56 -7.73 -0.39 1.29e-13 Renal function-related traits (BUN); LUSC cis rs778371 0.676 rs921055 chr2:233697337 A/C cg08000102 chr2:233561755 GIGYF2 -0.77 -12.2 -0.56 1.46e-28 Schizophrenia; LUSC cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg04455712 chr21:45112962 RRP1B 0.47 8.82 0.43 6.42e-17 Mean corpuscular volume; LUSC cis rs34779708 0.966 rs12775548 chr10:35479504 G/T cg04310649 chr10:35416472 CREM -0.4 -6.12 -0.32 2.64e-9 Inflammatory bowel disease;Crohn's disease; LUSC trans rs7980799 0.935 rs7312012 chr12:33517984 A/G cg26384229 chr12:38710491 ALG10B -0.42 -5.99 -0.31 5.53e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs6545883 0.831 rs1186704 chr2:61672991 A/G cg15711740 chr2:61764176 XPO1 -0.45 -6.99 -0.36 1.5e-11 Tuberculosis; LUSC cis rs10782582 0.593 rs77733234 chr1:76101655 A/T cg03433033 chr1:76189801 ACADM -0.48 -7.33 -0.37 1.8e-12 Daytime sleep phenotypes; LUSC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg10755058 chr3:40428713 ENTPD3 0.36 5.98 0.31 5.63e-9 Renal cell carcinoma; LUSC cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg05855489 chr10:104503620 C10orf26 -0.71 -11.68 -0.54 1.16e-26 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs61931739 0.500 rs73103774 chr12:34482279 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.58 0.5 9.58e-23 Morning vs. evening chronotype; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg11965913 chr1:205819406 PM20D1 0.93 19.27 0.73 3.8e-56 Menarche (age at onset); LUSC trans rs11610422 1.000 rs12824070 chr12:31414280 C/T cg02734259 chr12:9559402 NA -0.59 -6.35 -0.33 7.09e-10 Coronary artery disease; LUSC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg05234568 chr11:5960015 NA 0.68 11.12 0.52 1.23e-24 DNA methylation (variation); LUSC cis rs6674970 0.518 rs15740 chr1:151040435 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.71 -9.13 -0.45 6.47e-18 Childhood ear infection; LUSC cis rs7772486 0.806 rs2247317 chr6:146217570 C/T cg23711669 chr6:146136114 FBXO30 0.81 14.85 0.63 1.16e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs10193935 0.901 rs222479 chr2:42656857 T/G cg27598129 chr2:42591480 NA -0.56 -7.73 -0.39 1.27e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs807669 0.565 rs5746682 chr22:19185526 C/T cg02655711 chr22:19163373 SLC25A1 0.72 13.29 0.59 1.16e-32 Metabolite levels; LUSC cis rs7507204 0.906 rs11671513 chr19:3429937 C/T cg08380311 chr19:3435252 NFIC 0.7 10.13 0.48 3.33e-21 Height; LUSC cis rs1775715 0.737 rs2778650 chr10:32106851 A/G cg18675610 chr10:32216311 ARHGAP12 0.29 6.34 0.33 7.56e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg19346786 chr7:2764209 NA -0.47 -7.78 -0.39 8.84e-14 Height; LUSC cis rs12464483 0.591 rs67686878 chr2:30895044 C/T cg07150166 chr2:30669952 LCLAT1 0.64 6.9 0.35 2.66e-11 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg23158103 chr7:148848205 ZNF398 -0.48 -7.88 -0.4 4.66e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs8055236 0.564 rs4619382 chr16:83196518 T/C cg27022570 chr14:50155261 POLE2 -0.44 -6.02 -0.31 4.53e-9 Coronary heart disease; LUSC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg25019033 chr10:957182 NA -0.51 -6.41 -0.33 5.04e-10 Eosinophil percentage of granulocytes; LUSC cis rs11158026 0.603 rs943914 chr14:55440068 C/A cg04306507 chr14:55594613 LGALS3 0.4 7.47 0.38 7e-13 Parkinson's disease; LUSC cis rs6582630 0.615 rs11182380 chr12:38511735 G/T cg13010199 chr12:38710504 ALG10B -0.43 -6.52 -0.34 2.67e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7809950 0.678 rs2107317 chr7:106899685 T/C cg23024343 chr7:107201750 COG5 -0.66 -10.06 -0.48 5.78e-21 Coronary artery disease; LUSC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg06637938 chr14:75390232 RPS6KL1 -0.51 -8.19 -0.41 5.55e-15 Height; LUSC cis rs4566357 0.557 rs6707158 chr2:227911269 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -8.21 -0.41 4.95e-15 Coronary artery disease; LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg11965913 chr1:205819406 PM20D1 1.04 25.1 0.81 7.3e-79 Menarche (age at onset); LUSC trans rs1728785 0.892 rs1617749 chr16:68580890 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.73 0.39 1.27e-13 Ulcerative colitis; LUSC trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.32 -0.33 8.18e-10 Triglycerides; LUSC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg25124228 chr12:125621409 AACS -0.59 -9.87 -0.48 2.44e-20 Post bronchodilator FEV1/FVC ratio; LUSC trans rs1493916 1.000 rs4393645 chr18:31394407 C/T cg15819921 chr19:927150 ARID3A -0.43 -6.25 -0.32 1.28e-9 Life satisfaction; LUSC cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg01849466 chr14:104193079 ZFYVE21 0.49 7.39 0.38 1.16e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg26314531 chr2:26401878 FAM59B 0.74 10.09 0.48 4.67e-21 Gut microbiome composition (summer); LUSC cis rs9303401 0.659 rs34878689 chr17:56694330 G/A cg25039879 chr17:56429692 SUPT4H1 0.69 9.17 0.45 4.94e-18 Cognitive test performance; LUSC cis rs7917772 0.582 rs4917976 chr10:104360518 A/G cg22532475 chr10:104410764 TRIM8 0.26 6.26 0.32 1.21e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg07701084 chr6:150067640 NUP43 0.55 8.39 0.42 1.37e-15 Lung cancer; LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.97 0.44 2.14e-17 Prudent dietary pattern; LUSC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg12463550 chr7:65579703 CRCP 0.63 5.7 0.3 2.7e-8 Diabetic kidney disease; LUSC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg19230755 chr7:65878503 NA -0.43 -6.02 -0.31 4.48e-9 Aortic root size; LUSC cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg03146154 chr1:46216737 IPP -0.51 -7.32 -0.37 1.84e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7759001 0.857 rs2206252 chr6:27358462 A/C cg18711553 chr6:27366782 ZNF391 0.4 5.99 0.31 5.44e-9 Glomerular filtration rate (creatinine); LUSC cis rs2652834 0.808 rs28583444 chr15:63357852 T/G cg05507819 chr15:63340323 TPM1 0.69 8.66 0.43 2.03e-16 HDL cholesterol; LUSC cis rs3741151 0.686 rs61516411 chr11:73302768 T/C cg17517138 chr11:73019481 ARHGEF17 0.76 7.04 0.36 1.07e-11 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.16 -0.52 8.86e-25 Alzheimer's disease; LUSC trans rs11098499 0.754 rs2036857 chr4:120249240 T/C cg25214090 chr10:38739885 LOC399744 0.44 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs16854884 0.609 rs9872126 chr3:143683851 G/A cg06585982 chr3:143692056 C3orf58 0.41 6.44 0.33 4.23e-10 Economic and political preferences (feminism/equality); LUSC cis rs4808199 1.000 rs60003758 chr19:19557353 A/G cg03709012 chr19:19516395 GATAD2A 1.1 14.47 0.62 3.47e-37 Nonalcoholic fatty liver disease; LUSC trans rs877282 0.838 rs34912955 chr10:772222 T/C cg22713356 chr15:30763199 NA 1.11 15.31 0.64 1.94e-40 Uric acid levels; LUSC trans rs17685 0.753 rs2108274 chr7:75781636 C/A cg19862616 chr7:65841803 NCRNA00174 1.14 19.9 0.74 1.2e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs243505 0.737 rs243513 chr7:148429806 G/A cg09806900 chr7:148480153 CUL1 -0.52 -6.8 -0.35 4.95e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg18681998 chr4:17616180 MED28 0.82 15.41 0.64 7.26e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6500602 0.964 rs2896893 chr16:4478559 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.46 6.07 0.32 3.42e-9 Schizophrenia; LUSC cis rs7818345 1.000 rs11204041 chr8:19291371 G/A cg11303988 chr8:19266685 CSGALNACT1 0.36 6.99 0.36 1.49e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs9527 0.830 rs10883790 chr10:104640955 A/C cg23093090 chr10:104574429 C10orf26 -0.38 -6.52 -0.34 2.61e-10 Arsenic metabolism; LUSC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg21028142 chr17:79581711 NPLOC4 -0.32 -7.79 -0.39 8.41e-14 Eye color traits; LUSC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.78 -0.39 9.31e-14 Reticulocyte count; LUSC cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg12365402 chr11:9010492 NRIP3 -0.41 -7.21 -0.37 3.82e-12 Hematocrit; LUSC trans rs629535 0.862 rs638412 chr8:70047690 C/T cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.65 9.87 0.48 2.53e-20 Height; LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.56 0.46 2.71e-19 Bipolar disorder; LUSC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.24 0.41 3.98e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs4595586 0.525 rs12812749 chr12:39363254 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.07 0.36 9.17e-12 Morning vs. evening chronotype; LUSC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg19046167 chr17:80928561 B3GNTL1 0.44 7.05 0.36 1.02e-11 Breast cancer; LUSC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg02951883 chr7:2050386 MAD1L1 0.44 5.9 0.31 8.92e-9 Bipolar disorder; LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg13012494 chr21:47604986 C21orf56 0.49 7.55 0.38 4.06e-13 Testicular germ cell tumor; LUSC cis rs6987853 0.661 rs6988493 chr8:42351328 C/T cg09913449 chr8:42400586 C8orf40 -0.45 -7.51 -0.38 5.34e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg19318889 chr4:1322082 MAEA 0.52 8.75 0.43 1.1e-16 Obesity-related traits; LUSC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg04478727 chr12:58166393 METTL1;FAM119B 0.41 5.74 0.3 2.09e-8 Multiple sclerosis; LUSC trans rs1728785 1.000 rs698728 chr16:68625253 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.69 0.39 1.67e-13 Ulcerative colitis; LUSC cis rs9326248 0.581 rs10892076 chr11:116988936 G/A cg11861562 chr11:117069780 TAGLN 0.37 7.31 0.37 2e-12 Blood protein levels; LUSC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.35e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1873147 0.731 rs12902152 chr15:63313968 T/C cg12160578 chr15:63334699 TPM1 -0.46 -6.18 -0.32 1.92e-9 Orofacial clefts; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00482020 chr16:25026850 ARHGAP17 -0.43 -5.95 -0.31 6.82e-9 Bipolar disorder and schizophrenia; LUSC cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg24642439 chr20:33292090 TP53INP2 0.55 8.19 0.41 5.74e-15 Height; LUSC trans rs17685 0.753 rs10264760 chr7:75749694 A/G cg19862616 chr7:65841803 NCRNA00174 1.12 19.04 0.72 3.1e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2361718 0.590 rs4527052 chr17:78140910 A/G cg23490090 chr17:78081364 GAA -0.37 -6.23 -0.32 1.44e-9 Yeast infection; LUSC cis rs10751667 0.666 rs6597967 chr11:950583 G/T ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.71e-9 Alzheimer's disease (late onset); LUSC cis rs9467773 1.000 rs9393731 chr6:26529374 C/T cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.88e-18 Intelligence (multi-trait analysis); LUSC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg08847533 chr14:75593920 NEK9 0.83 14.52 0.62 2.18e-37 Height; LUSC cis rs12776158 0.685 rs60677596 chr10:71216880 A/G cg12610070 chr10:71211762 TSPAN15 -0.46 -5.93 -0.31 7.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2120019 0.567 rs72625793 chr15:75207083 A/G cg09165964 chr15:75287851 SCAMP5 -0.96 -11.82 -0.54 3.63e-27 Blood trace element (Zn levels); LUSC cis rs7582180 0.629 rs12617779 chr2:100937707 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.35 -0.42 1.82e-15 Intelligence (multi-trait analysis); LUSC cis rs740160 0.558 rs17161669 chr7:98908663 G/A cg24650262 chr7:98904301 NA 0.6 6.32 0.33 8.28e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg20849893 chr7:64541193 NA -0.65 -5.74 -0.3 2.07e-8 Diabetic kidney disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04724115 chr22:39052386 LOC646851;CBY1 -0.45 -6.71 -0.34 8.53e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg11645453 chr3:52864694 ITIH4 0.35 8.16 0.41 6.91e-15 Bipolar disorder; LUSC trans rs67340775 0.541 rs200966 chr6:27862152 T/C cg05267876 chr1:229644265 NUP133 -0.55 -6.15 -0.32 2.24e-9 Lung cancer in ever smokers; LUSC cis rs9473147 0.543 rs9296558 chr6:47451883 C/T cg12968598 chr6:47444699 CD2AP 0.54 8.19 0.41 5.64e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs12530845 0.943 rs58577912 chr7:135329269 T/G cg23117316 chr7:135346802 PL-5283 -0.58 -9.63 -0.47 1.55e-19 Red blood cell traits; LUSC cis rs1577917 0.771 rs2842602 chr6:86331887 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.72 -0.43 1.28e-16 Response to antipsychotic treatment; LUSC cis rs9788721 0.836 rs1504550 chr15:78766250 A/G cg18825076 chr15:78729989 IREB2 -0.61 -9.53 -0.46 3.26e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs3942852 0.868 rs6485808 chr11:48109151 A/G cg15704280 chr7:45808275 SEPT13 -0.56 -6.48 -0.33 3.23e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs2219968 1.000 rs6473086 chr8:78974646 T/C cg00738934 chr8:78996279 NA 0.37 6.86 0.35 3.39e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs35146811 0.735 rs11767968 chr7:99790971 G/A cg19116668 chr7:99932089 PMS2L1 -0.33 -5.67 -0.3 3.17e-8 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11814312 chr17:76672156 CYTH1 0.46 6.39 0.33 5.64e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.84 -0.47 3.05e-20 Body mass index; LUSC cis rs6733011 0.578 rs1878585 chr2:99501698 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.31 -0.33 8.78e-10 Bipolar disorder; LUSC cis rs6733011 0.604 rs12712035 chr2:99461298 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.45 -6.38 -0.33 5.77e-10 Bipolar disorder; LUSC cis rs73198271 0.599 rs10103169 chr8:8650698 T/A cg01851573 chr8:8652454 MFHAS1 0.52 8.44 0.42 9.81e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg19346786 chr7:2764209 NA -0.39 -6.94 -0.35 2.09e-11 Height; LUSC cis rs13082711 0.911 rs11708710 chr3:27457348 A/C cg02860705 chr3:27208620 NA 0.52 8.71 0.43 1.44e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs6600671 0.932 rs6600663 chr1:121222437 A/T cg00646200 chr1:148855367 NA 0.46 7.12 0.36 6.57e-12 Hip geometry; LUSC trans rs2262909 0.962 rs408687 chr19:22231123 T/C cg17074339 chr11:11642133 GALNTL4 -0.46 -7.07 -0.36 9.1e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs12410462 0.579 rs78343168 chr1:227621090 G/A cg23173402 chr1:227635558 NA 0.75 8.14 0.41 8.12e-15 Major depressive disorder; LUSC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.47 -6.98 -0.36 1.61e-11 Alzheimer's disease (late onset); LUSC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.6 0.46 2.03e-19 Hip circumference adjusted for BMI; LUSC cis rs9660992 0.512 rs12142402 chr1:205128215 A/T cg03948781 chr1:205179583 DSTYK 0.32 6.24 0.32 1.34e-9 Mean corpuscular volume;Mean platelet volume; LUSC cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg04455712 chr21:45112962 RRP1B -0.46 -8.69 -0.43 1.68e-16 Mean corpuscular volume; LUSC cis rs6582630 0.576 rs4882375 chr12:38371939 G/T cg26384229 chr12:38710491 ALG10B -0.55 -8.25 -0.41 3.73e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs9341808 0.718 rs9343978 chr6:80971978 A/G cg08355045 chr6:80787529 NA 0.56 9.76 0.47 5.61e-20 Sitting height ratio; LUSC cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg02269571 chr22:50332266 NA 0.58 8.61 0.43 2.88e-16 Schizophrenia; LUSC cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg26384229 chr12:38710491 ALG10B 0.94 17.87 0.7 1.34e-50 Heart rate; LUSC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.39 -7.45 -0.38 7.92e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs12478296 1.000 rs7603984 chr2:243047294 A/G cg06360820 chr2:242988706 NA -0.9 -9.61 -0.47 1.82e-19 Obesity-related traits; LUSC cis rs7589342 0.801 rs13031068 chr2:106455021 A/G cg16077055 chr2:106428750 NCK2 0.37 6.96 0.36 1.84e-11 Addiction; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg01171360 chr6:293285 DUSP22 -0.69 -11.15 -0.52 9.28e-25 Menopause (age at onset); LUSC trans rs1941687 0.831 rs28402875 chr18:31351506 G/A cg27147174 chr7:100797783 AP1S1 -0.47 -6.85 -0.35 3.46e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7246967 0.673 rs7252925 chr19:22865808 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs500891 1.000 rs500891 chr6:84196790 A/G cg08257003 chr6:84140564 ME1 -0.32 -6.63 -0.34 1.34e-10 Platelet-derived growth factor BB levels; LUSC trans rs7726839 0.794 rs10053310 chr5:595661 C/G cg25482853 chr8:67687455 SGK3 0.8 11.24 0.52 4.47e-25 Obesity-related traits; LUSC cis rs9796 0.870 rs12910027 chr15:41283817 A/T cg18705301 chr15:41695430 NDUFAF1 0.47 8.26 0.41 3.44e-15 Menopause (age at onset); LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg20821713 chr7:1055600 C7orf50 -0.48 -7.85 -0.39 5.76e-14 Longevity;Endometriosis; LUSC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11890956 chr21:40555474 PSMG1 0.98 18.79 0.72 3e-54 Cognitive function; LUSC cis rs6580649 0.882 rs7133249 chr12:48456823 C/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.07 -0.32 3.47e-9 Lung cancer; LUSC trans rs6502050 0.805 rs9898326 chr17:80119582 C/T cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs11931598 0.513 rs3857170 chr4:7003366 A/T cg26116260 chr4:7069785 GRPEL1 0.42 6.3 0.33 9.51e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs6546886 0.912 rs4241260 chr2:74293395 C/T cg14702570 chr2:74259524 NA -0.3 -5.68 -0.3 2.89e-8 Dialysis-related mortality; LUSC cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs4808199 0.895 rs10421505 chr19:19459554 C/T cg03709012 chr19:19516395 GATAD2A 0.97 12.18 0.55 1.66e-28 Nonalcoholic fatty liver disease; LUSC cis rs9837602 1.000 rs34626154 chr3:99756312 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.09 0.32 3.14e-9 Breast cancer; LUSC trans rs10802346 0.515 rs1113270 chr1:246423217 A/G cg22732515 chr19:44031385 ETHE1 0.66 10.69 0.5 3.87e-23 Fractional exhaled nitric oxide (childhood); LUSC trans rs61931739 0.500 rs11053166 chr12:34385898 A/C cg26384229 chr12:38710491 ALG10B -0.86 -14.8 -0.63 1.77e-38 Morning vs. evening chronotype; LUSC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.19 -0.32 1.78e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs17125944 0.505 rs118053951 chr14:53259829 G/A cg13660082 chr14:53194042 PSMC6 -0.78 -6.43 -0.33 4.36e-10 Alzheimer's disease (late onset); LUSC cis rs7181230 0.961 rs7183977 chr15:40377092 C/T cg00868766 chr15:40364524 NA -0.35 -6.1 -0.32 2.94e-9 Dehydroepiandrosterone sulphate levels; LUSC cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg00074818 chr8:8560427 CLDN23 0.59 9.95 0.48 1.33e-20 Obesity-related traits; LUSC cis rs7851660 0.809 rs7022148 chr9:100660824 T/C cg13688889 chr9:100608707 NA -0.54 -8.44 -0.42 9.53e-16 Strep throat; LUSC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg22508957 chr16:3507546 NAT15 0.93 10.44 0.5 2.86e-22 Tuberculosis; LUSC cis rs7582180 0.606 rs12618908 chr2:100947026 A/T cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg14784868 chr12:69753453 YEATS4 0.84 14.12 0.61 7.89e-36 Blood protein levels; LUSC cis rs6499188 1.000 rs6499188 chr16:68674788 G/A cg02972257 chr16:68554789 NA -0.48 -6.19 -0.32 1.77e-9 Ulcerative colitis; LUSC cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg03146154 chr1:46216737 IPP -0.52 -7.71 -0.39 1.49e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3741151 0.686 rs73546735 chr11:73256797 C/T cg17517138 chr11:73019481 ARHGEF17 0.97 8.12 0.41 8.78e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg20399509 chr21:47717575 C21orf57 -0.39 -5.96 -0.31 6.5e-9 Testicular germ cell tumor; LUSC cis rs6740322 0.895 rs11684601 chr2:43574242 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.54 -7.88 -0.4 4.75e-14 Coronary artery disease; LUSC cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg20503657 chr10:835505 NA 0.98 13.9 0.61 5.53e-35 Eosinophil percentage of granulocytes; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.43 0.53 9.29e-26 Prudent dietary pattern; LUSC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg06287003 chr12:125626642 AACS -0.4 -6.13 -0.32 2.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs763121 0.853 rs138704 chr22:39133410 A/G cg06544989 chr22:39130855 UNC84B 0.37 6.36 0.33 6.56e-10 Menopause (age at onset); LUSC cis rs9815354 0.812 rs17218504 chr3:41987278 A/G cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs754466 0.580 rs12354903 chr10:79536465 T/C cg17075019 chr10:79541650 NA -0.77 -12.24 -0.56 1.03e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7681440 0.874 rs1372524 chr4:90776045 A/G cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.23e-8 Dementia with Lewy bodies; LUSC cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs6831352 0.840 rs34634551 chr4:100067362 C/A cg12011299 chr4:100065546 ADH4 -0.72 -10.42 -0.5 3.38e-22 Alcohol dependence; LUSC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg16049864 chr8:95962084 TP53INP1 -0.43 -7.17 -0.37 4.84e-12 Type 2 diabetes; LUSC cis rs2455601 0.679 rs2653559 chr11:8900394 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -6.91 -0.35 2.44e-11 Schizophrenia; LUSC trans rs1135642 0.509 rs78111759 chr4:77807626 A/G cg27323975 chr12:129436478 GLT1D1 -0.77 -6.02 -0.31 4.64e-9 Food addiction; LUSC cis rs7568458 0.837 rs6547624 chr2:85802134 A/T cg23752985 chr2:85803571 VAMP8 0.36 7.87 0.4 5.05e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.68 11.27 0.53 3.36e-25 Total body bone mineral density; LUSC cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg24130564 chr14:104152367 KLC1 -0.42 -6.07 -0.32 3.38e-9 Body mass index; LUSC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 13.91 0.61 5.26e-35 Allergic disease (asthma, hay fever or eczema); LUSC cis rs8014204 0.604 rs12147862 chr14:75384471 C/T cg11812906 chr14:75593930 NEK9 -0.39 -5.69 -0.3 2.75e-8 Caffeine consumption; LUSC cis rs7829975 0.755 rs3789849 chr8:8687054 G/C cg08975724 chr8:8085496 FLJ10661 0.5 7.36 0.37 1.4e-12 Mood instability; LUSC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg20891558 chr2:74357851 NA 0.85 15.66 0.65 7.91e-42 Gestational age at birth (maternal effect); LUSC cis rs9467773 0.935 rs9461270 chr6:26544110 A/G cg11502198 chr6:26597334 ABT1 0.59 9.37 0.46 1.15e-18 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.967 rs373704 chr6:145860618 C/A cg23711669 chr6:146136114 FBXO30 0.73 12.76 0.57 1.22e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg10792982 chr14:105748885 BRF1 0.48 8.68 0.43 1.75e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs6076065 0.548 rs6048742 chr20:23327584 T/C cg11657817 chr20:23433608 CST11 0.51 10.14 0.49 3.08e-21 Facial morphology (factor 15, philtrum width); LUSC trans rs72674100 1.000 rs10005163 chr4:97959097 C/T cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs1997103 1.000 rs1965556 chr7:55403584 C/G cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg26597838 chr10:835615 NA 0.99 13.79 0.6 1.42e-34 Eosinophil percentage of granulocytes; LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg27170947 chr2:26402098 FAM59B -0.72 -11.04 -0.52 2.26e-24 Gut microbiome composition (summer); LUSC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg13319975 chr6:146136371 FBXO30 0.7 11.14 0.52 9.86e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs8014204 0.935 rs8010840 chr14:75355203 T/C cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.44 -0.53 8.62e-26 Caffeine consumption; LUSC cis rs7824557 0.564 rs2572379 chr8:11237480 A/G cg21775007 chr8:11205619 TDH -0.65 -10.26 -0.49 1.22e-21 Retinal vascular caliber; LUSC cis rs12618769 0.947 rs72825711 chr2:99240243 A/T cg10123293 chr2:99228465 UNC50 0.41 5.7 0.3 2.57e-8 Bipolar disorder; LUSC cis rs13315871 0.929 rs9857333 chr3:58293551 G/C cg12435725 chr3:58293450 RPP14 -0.69 -7.16 -0.36 5.24e-12 Cholesterol, total; LUSC cis rs2734839 0.964 rs11214605 chr11:113300601 C/T cg14159747 chr11:113255604 NA 0.23 5.72 0.3 2.31e-8 Information processing speed; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg03395511 chr6:291903 DUSP22 -0.7 -11.52 -0.53 4.49e-26 Menopause (age at onset); LUSC cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg08999081 chr20:33150536 PIGU 0.52 10.43 0.5 3.08e-22 Glomerular filtration rate (creatinine); LUSC cis rs6121246 0.909 rs6060870 chr20:30303299 C/T cg18721089 chr20:30220636 NA -0.34 -5.95 -0.31 6.9e-9 Mean corpuscular hemoglobin; LUSC trans rs11098499 0.909 rs7659501 chr4:120371552 G/T cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.79 0.3 1.66e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11637445 0.677 rs4386088 chr15:68108913 G/A cg08079166 chr15:68083412 MAP2K5 0.35 7.21 0.37 3.84e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.28 0.59 1.35e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg02986439 chr15:66545422 MEGF11 -0.41 -5.98 -0.31 5.77e-9 Hepatitis; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.68 0.34 1.02e-10 Obesity-related traits; LUSC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg24838063 chr12:130822603 PIWIL1 0.71 11.06 0.52 1.98e-24 Menopause (age at onset); LUSC cis rs7267979 0.816 rs422148 chr20:25512604 G/C cg03522245 chr20:25566470 NINL 0.36 5.82 0.3 1.38e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1865760 0.865 rs9467650 chr6:25958235 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 6.87 0.35 3.17e-11 Height; LUSC cis rs7617480 0.648 rs4858800 chr3:48755820 A/G cg07636037 chr3:49044803 WDR6 0.78 10.32 0.49 7.27e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs921968 0.565 rs7599365 chr2:219620566 G/A cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg18352616 chr4:3374830 RGS12 0.34 7.09 0.36 8.12e-12 Serum sulfate level; LUSC cis rs1371867 0.875 rs1788173 chr8:101330939 A/G cg00191853 chr8:101177733 SPAG1 0.37 6.32 0.33 8.45e-10 Atrioventricular conduction; LUSC cis rs7903847 0.642 rs10882914 chr10:99142057 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.28 -0.37 2.45e-12 Granulocyte percentage of myeloid white cells; LUSC trans rs7829975 0.755 rs3789849 chr8:8687054 G/C cg27411982 chr8:10470053 RP1L1 0.39 6.16 0.32 2.06e-9 Mood instability; LUSC cis rs12474201 0.928 rs12998753 chr2:46938385 A/G cg06386533 chr2:46925753 SOCS5 0.76 11.34 0.53 1.89e-25 Height; LUSC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg08270630 chr22:50330655 NA 0.41 6.13 0.32 2.44e-9 Schizophrenia; LUSC cis rs11122272 0.705 rs2572260 chr1:231486189 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.87 -0.48 2.48e-20 Hemoglobin concentration; LUSC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.75 -0.8 1.56e-77 Height; LUSC cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg08213375 chr14:104286397 PPP1R13B -0.53 -10.14 -0.49 2.96e-21 Schizophrenia; LUSC cis rs500891 0.525 rs6454322 chr6:84057542 A/G cg08257003 chr6:84140564 ME1 0.34 8.18 0.41 6.19e-15 Platelet-derived growth factor BB levels; LUSC cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg12463550 chr7:65579703 CRCP 0.56 8.29 0.41 2.86e-15 Aortic root size; LUSC cis rs10911232 0.507 rs10752890 chr1:183021910 A/G ch.1.3577855R chr1:183094577 LAMC1 0.7 10.89 0.51 7.63e-24 Hypertriglyceridemia; LUSC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg12560992 chr17:57184187 TRIM37 -0.85 -15.42 -0.64 6.9e-41 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.525 rs11612680 chr12:39344443 A/G cg26384229 chr12:38710491 ALG10B 0.55 7.79 0.39 8.68e-14 Morning vs. evening chronotype; LUSC cis rs2652834 1.000 rs2652835 chr15:63396408 T/C cg05507819 chr15:63340323 TPM1 0.67 8.15 0.41 7.29e-15 HDL cholesterol; LUSC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg12927641 chr6:109611667 NA -0.43 -7.62 -0.38 2.71e-13 Reticulocyte fraction of red cells; LUSC cis rs950776 0.714 rs17408276 chr15:78881618 T/C cg06917634 chr15:78832804 PSMA4 0.72 11.56 0.53 3.08e-26 Sudden cardiac arrest; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13126279 chr21:47581558 C21orf56 0.54 8.47 0.42 8.07e-16 Testicular germ cell tumor; LUSC cis rs77972916 0.561 rs4372955 chr2:43566146 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -5.95 -0.31 6.66e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs2522056 1.000 rs2522050 chr5:131796609 C/T cg24060327 chr5:131705240 SLC22A5 0.45 5.96 0.31 6.39e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs16866061 1.000 rs10933068 chr2:225418360 G/A cg12698349 chr2:225449008 CUL3 0.85 13.64 0.6 5.63e-34 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs7312933 0.558 rs11181483 chr12:42798384 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.85 0.35 3.61e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2486288 0.554 rs1719235 chr15:45576108 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.71 -0.39 1.44e-13 Glomerular filtration rate; LUSC cis rs34779708 0.931 rs4351760 chr10:35280254 A/G cg04310649 chr10:35416472 CREM -0.44 -6.58 -0.34 1.85e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2688608 0.901 rs2664280 chr10:75617344 A/T cg23231163 chr10:75533350 FUT11 0.41 6.47 0.33 3.43e-10 Inflammatory bowel disease; LUSC cis rs2637266 1.000 rs12262400 chr10:78386862 T/C cg18941641 chr10:78392320 NA 0.4 7.33 0.37 1.79e-12 Pulmonary function; LUSC trans rs62238980 0.614 rs77017871 chr22:32382145 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs2295359 0.892 rs10789224 chr1:67605134 C/T cg03340356 chr1:67600835 NA -0.43 -6.81 -0.35 4.57e-11 Psoriasis; LUSC cis rs908922 0.651 rs1988805 chr1:152531495 T/G cg20991723 chr1:152506922 NA 0.48 8.99 0.44 1.91e-17 Hair morphology; LUSC cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs12928939 0.517 rs9940234 chr16:71964805 C/T cg03805757 chr16:71968109 PKD1L3 -0.63 -9.69 -0.47 1.01e-19 Post bronchodilator FEV1; LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs11958404 0.932 rs72816566 chr5:157427613 G/A cg05962755 chr5:157440814 NA 0.51 6.18 0.32 1.89e-9 IgG glycosylation; LUSC cis rs7715806 0.500 rs17649350 chr5:75006156 C/T cg19683494 chr5:74908142 NA -0.55 -7.54 -0.38 4.46e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg26314531 chr2:26401878 FAM59B 0.67 8.72 0.43 1.36e-16 Gut microbiome composition (summer); LUSC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg27535305 chr1:53392650 SCP2 -0.4 -7.5 -0.38 5.74e-13 Monocyte count; LUSC trans rs7893279 0.749 rs4748464 chr10:18712258 C/A cg01840055 chr3:141338555 NA 0.5 5.94 0.31 7.03e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg13453750 chr1:205783389 SLC41A1 -0.33 -6.41 -0.33 4.83e-10 Menarche (age at onset); LUSC cis rs908922 0.676 rs11205018 chr1:152496249 T/G cg20991723 chr1:152506922 NA 0.52 9.8 0.47 4.38e-20 Hair morphology; LUSC cis rs4930103 0.904 rs4929984 chr11:2024683 A/C cg06197492 chr11:2016605 H19 -0.39 -6.58 -0.34 1.84e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7954584 0.635 rs7313252 chr12:122347600 G/A cg13699009 chr12:122356056 WDR66 0.48 7.49 0.38 6.33e-13 Mean corpuscular volume; LUSC cis rs1997103 1.000 rs10278894 chr7:55404748 A/G cg17469321 chr7:55412551 NA 0.66 10.62 0.5 6.87e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9633740 0.947 rs1878036 chr10:82280137 T/G cg01528321 chr10:82214614 TSPAN14 0.99 10.75 0.51 2.32e-23 Post bronchodilator FEV1; LUSC cis rs11098499 0.754 rs11732087 chr4:120239831 A/G cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg16145915 chr7:1198662 ZFAND2A -0.52 -9.59 -0.46 2.14e-19 Longevity;Endometriosis; LUSC cis rs3820928 0.605 rs13410141 chr2:227805529 A/G cg11843606 chr2:227700838 RHBDD1 -0.64 -10.12 -0.48 3.44e-21 Pulmonary function; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26847093 chr13:51483765 RNASEH2B 0.43 6.08 0.32 3.37e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.1 0.41 1.01e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs1692120 0.545 rs1812458 chr11:61408449 C/T cg19838087 chr11:61442541 NA -0.32 -5.97 -0.31 6.07e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg17366294 chr4:99064904 C4orf37 0.58 10.24 0.49 1.42e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.546 rs10461174 chr4:98698293 G/A cg03676636 chr4:99064102 C4orf37 0.29 5.67 0.3 3.13e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9837602 0.938 rs9814359 chr3:99797013 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.99 -0.31 5.43e-9 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09739887 chr4:7105262 FLJ36777 0.41 6.09 0.32 3.04e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs12579753 0.869 rs12366920 chr12:82223015 G/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.43 -0.33 4.54e-10 Resting heart rate; LUSC cis rs66887589 0.837 rs7661498 chr4:120408108 T/C cg09307838 chr4:120376055 NA 0.48 7.2 0.37 4.07e-12 Diastolic blood pressure; LUSC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg03806693 chr22:41940476 POLR3H -1.04 -14.89 -0.63 8.23e-39 Vitiligo; LUSC cis rs2235649 0.624 rs2076427 chr16:1817754 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 0.46 5.75 0.3 1.96e-8 Blood metabolite levels; LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg02018176 chr4:1364513 KIAA1530 -0.67 -11.6 -0.54 2.36e-26 Obesity-related traits; LUSC cis rs75920871 0.528 rs1241655 chr11:116837808 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.23 -0.32 1.4e-9 Subjective well-being; LUSC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg21724239 chr8:58056113 NA 0.81 8.84 0.44 5.66e-17 Developmental language disorder (linguistic errors); LUSC trans rs11118993 0.936 rs11587643 chr1:206714520 G/A cg25718223 chr19:13915877 ZSWIM4 -0.36 -6.05 -0.31 3.81e-9 Neurofibrillary tangles; LUSC cis rs6484504 0.532 rs2774403 chr11:31320530 A/T cg26647111 chr11:31128758 NA 0.39 5.73 0.3 2.3e-8 Red blood cell count; LUSC cis rs11864453 0.826 rs12708928 chr16:72137227 C/A cg16558253 chr16:72132732 DHX38 -0.43 -6.49 -0.33 3.09e-10 Fibrinogen levels; LUSC cis rs11098499 0.954 rs3733523 chr4:120423719 C/T cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg00784671 chr22:46762841 CELSR1 -0.48 -6.53 -0.34 2.42e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9399401 0.589 rs2294775 chr6:142766347 C/G cg03128060 chr6:142623767 GPR126 0.48 8.83 0.44 5.86e-17 Chronic obstructive pulmonary disease; LUSC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg13319975 chr6:146136371 FBXO30 0.51 7.63 0.39 2.49e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg00071950 chr4:10020882 SLC2A9 -0.57 -9.51 -0.46 3.99e-19 Bone mineral density; LUSC trans rs11039798 0.920 rs12292685 chr11:48571032 G/T cg15704280 chr7:45808275 SEPT13 0.69 6.51 0.34 2.81e-10 Axial length; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23214606 chr1:202976451 TMEM183A;TMEM183B 0.44 6.03 0.31 4.38e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10979 1.000 rs9484768 chr6:143887928 C/T cg25407410 chr6:143891975 LOC285740 -0.75 -12.09 -0.55 3.8e-28 Hypospadias; LUSC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.86 -0.54 2.59e-27 Extrinsic epigenetic age acceleration; LUSC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg15145296 chr3:125709740 NA -0.54 -6.02 -0.31 4.57e-9 Blood pressure (smoking interaction); LUSC cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.93 -0.31 7.69e-9 IgG glycosylation; LUSC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg08219700 chr8:58056026 NA 0.67 8.37 0.42 1.63e-15 Developmental language disorder (linguistic errors); LUSC cis rs61869271 0.871 rs12098332 chr10:116728074 A/T cg23260525 chr10:116636907 FAM160B1 0.32 6.38 0.33 5.75e-10 Tonsillectomy; LUSC cis rs9430161 0.645 rs12081186 chr1:11034195 T/C cg27631724 chr1:11040367 C1orf127 0.54 9.4 0.46 8.69e-19 Ewing sarcoma; LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg06873352 chr17:61820015 STRADA -0.62 -10.74 -0.51 2.63e-23 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC cis rs11122272 0.638 rs2739514 chr1:231514806 G/A cg06096015 chr1:231504339 EGLN1 0.55 9.63 0.47 1.56e-19 Hemoglobin concentration; LUSC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg25282410 chr6:160211355 TCP1;MRPL18 1.1 16.96 0.68 5.39e-47 Age-related macular degeneration (geographic atrophy); LUSC cis rs11764590 0.694 rs55860148 chr7:2105594 G/A cg02951883 chr7:2050386 MAD1L1 0.46 6.13 0.32 2.47e-9 Neuroticism; LUSC trans rs6736587 0.744 rs11673910 chr2:81932861 T/C cg14247332 chr9:132805979 FNBP1 0.44 6.0 0.31 5.2e-9 Orthostatic hypotension; LUSC cis rs929354 0.742 rs10251112 chr7:156963524 A/G cg17757837 chr7:157058334 UBE3C 0.81 12.99 0.58 1.68e-31 Body mass index; LUSC trans rs45509595 0.841 rs200485 chr6:27775697 G/C cg06606381 chr12:133084897 FBRSL1 -0.72 -7.28 -0.37 2.47e-12 Breast cancer; LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg05368731 chr17:41323189 NBR1 0.92 15.51 0.65 2.92e-41 Menopause (age at onset); LUSC cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg27129171 chr3:47204927 SETD2 -0.69 -11.38 -0.53 1.42e-25 Colorectal cancer; LUSC cis rs11098499 0.909 rs9759478 chr4:120367998 G/A cg09307838 chr4:120376055 NA 0.77 11.2 0.52 6.25e-25 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01656856 chr2:170551263 PHOSPHO2;KLHL23;C2orf77 0.42 6.07 0.32 3.5e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs72960926 0.744 rs11754468 chr6:74932522 C/T cg03266952 chr6:74778945 NA -0.77 -6.79 -0.35 5.08e-11 Metabolite levels (MHPG); LUSC cis rs6845621 0.840 rs6816238 chr4:18918968 T/C cg12196642 chr4:18937545 NA -0.33 -6.38 -0.33 5.78e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9815354 0.812 rs56728371 chr3:41999381 T/A cg03022575 chr3:42003672 ULK4 0.81 8.53 0.42 5.02e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg12365402 chr11:9010492 NRIP3 0.47 8.77 0.43 9.02e-17 Hemoglobin concentration; LUSC cis rs6121246 0.657 rs74392247 chr20:30241737 C/T cg18721089 chr20:30220636 NA -0.39 -6.02 -0.31 4.5e-9 Mean corpuscular hemoglobin; LUSC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg13390004 chr1:15929781 NA 0.38 6.49 0.33 3.04e-10 Systolic blood pressure; LUSC cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg05340658 chr4:99064831 C4orf37 0.68 11.58 0.54 2.61e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg20203395 chr5:56204925 C5orf35 -0.71 -9.61 -0.47 1.79e-19 Initial pursuit acceleration; LUSC cis rs11608355 0.515 rs2270361 chr12:109935894 G/C cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs977987 0.872 rs3743609 chr16:75467021 G/C cg04384234 chr16:75411784 CFDP1 -0.45 -7.44 -0.38 8.59e-13 Dupuytren's disease; LUSC cis rs7000551 0.700 rs2461480 chr8:22381839 C/T cg12081754 chr8:22256438 SLC39A14 0.43 6.43 0.33 4.3e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4839421 0.966 rs6677767 chr1:111022475 C/T cg06880108 chr1:111021908 CYMP -0.43 -7.26 -0.37 2.73e-12 Response to bupropion in depression; LUSC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg22834771 chr12:69754056 YEATS4 -0.43 -6.23 -0.32 1.41e-9 Blood protein levels; LUSC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg21435336 chr19:17392852 ANKLE1 -0.47 -6.33 -0.33 7.67e-10 Systemic lupus erythematosus; LUSC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg11843238 chr5:131593191 PDLIM4 0.38 6.52 0.34 2.54e-10 Breast cancer; LUSC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg21016266 chr12:122356598 WDR66 0.61 9.24 0.45 3.05e-18 Mean corpuscular volume; LUSC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg00450029 chr8:599525 NA -0.59 -5.69 -0.3 2.82e-8 IgG glycosylation; LUSC cis rs4595586 0.525 rs7313120 chr12:39388027 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs738322 1.000 rs738322 chr22:38569006 A/G cg17652424 chr22:38574118 PLA2G6 -0.3 -6.63 -0.34 1.39e-10 Cutaneous nevi; LUSC trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.56 -0.34 1.99e-10 Monocyte count; LUSC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg22903471 chr2:27725779 GCKR 0.41 6.99 0.36 1.48e-11 Total body bone mineral density; LUSC cis rs9517320 0.534 rs9556962 chr13:99156648 C/T cg07423050 chr13:99094983 FARP1 -0.56 -10.83 -0.51 1.3e-23 Longevity; LUSC cis rs7246967 0.611 rs12973627 chr19:22867705 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.01 0.31 4.91e-9 Bronchopulmonary dysplasia; LUSC cis rs11122272 0.735 rs2790880 chr1:231534259 C/T cg06096015 chr1:231504339 EGLN1 0.58 10.36 0.49 5.56e-22 Hemoglobin concentration; LUSC cis rs2953145 0.568 rs1133352 chr2:241522252 A/G cg07929629 chr2:241523174 NA -0.57 -10.86 -0.51 1e-23 Bipolar disorder; LUSC cis rs6138458 1.000 rs6114980 chr20:24974288 A/G cg26195577 chr20:24973756 C20orf3 1.11 18.48 0.71 5e-53 Blood protein levels; LUSC cis rs780094 0.500 rs13002853 chr2:27853245 C/G cg27432699 chr2:27873401 GPN1 0.43 5.86 0.31 1.1e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs1801251 0.711 rs2592117 chr2:233735693 C/T cg08000102 chr2:233561755 GIGYF2 -0.51 -8.09 -0.4 1.13e-14 Coronary artery disease; LUSC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg06671706 chr8:8559999 CLDN23 0.5 6.8 0.35 4.85e-11 Obesity-related traits; LUSC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg05313129 chr8:58192883 C8orf71 -0.51 -6.52 -0.34 2.59e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs6967256 chr7:91643219 G/A cg17063962 chr7:91808500 NA 0.57 9.07 0.44 1.02e-17 Breast cancer; LUSC cis rs8017423 1.000 rs4900028 chr14:90685594 C/T cg14092571 chr14:90743983 NA -0.36 -5.99 -0.31 5.48e-9 Mortality in heart failure; LUSC cis rs2777491 0.957 rs8026197 chr15:41711447 C/T cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.48 -0.59 2.36e-33 Ulcerative colitis; LUSC cis rs12050794 0.636 rs3759902 chr15:72525274 C/G cg16672083 chr15:72433130 SENP8 0.47 7.87 0.4 5.04e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.7 -0.34 9.12e-11 Alzheimer's disease (late onset); LUSC cis rs1891275 0.515 rs1592051 chr10:93542186 A/G cg07889827 chr10:93443413 NA 0.39 8.91 0.44 3.44e-17 Intelligence (multi-trait analysis); LUSC cis rs295140 1.000 rs1367857 chr2:201160765 T/C cg04283868 chr2:201171347 SPATS2L 0.44 6.69 0.34 9.14e-11 QT interval; LUSC trans rs7824557 0.545 rs2572450 chr8:11229638 C/T cg15556689 chr8:8085844 FLJ10661 -0.57 -8.62 -0.43 2.64e-16 Retinal vascular caliber; LUSC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg10356904 chr22:49881777 NA -0.33 -7.39 -0.37 1.21e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1348850 0.757 rs2166554 chr2:178455824 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.24 0.32 1.35e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg07537917 chr2:241836409 C2orf54 -0.25 -5.72 -0.3 2.37e-8 Urinary metabolites; LUSC cis rs7804356 0.817 rs4719882 chr7:26882252 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.67e-9 Type 1 diabetes; LUSC cis rs2607426 0.681 rs10420685 chr19:41235120 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.92 6.83 0.35 3.91e-11 Blood protein levels; LUSC cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg14844989 chr11:31128820 NA -0.37 -5.9 -0.31 8.97e-9 Red blood cell count; LUSC cis rs2637266 0.714 rs6480835 chr10:78446863 T/C cg18941641 chr10:78392320 NA 0.33 5.98 0.31 5.67e-9 Pulmonary function; LUSC cis rs11190604 1.000 rs4604805 chr10:102261409 C/G cg07080220 chr10:102295463 HIF1AN 0.65 8.87 0.44 4.48e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg24692254 chr21:30365293 RNF160 -0.81 -15.0 -0.63 2.95e-39 Dental caries; LUSC trans rs17086172 0.841 rs76610733 chr18:70268315 C/G cg15710198 chr8:55370334 SOX17 -0.67 -6.11 -0.32 2.73e-9 Airflow obstruction; LUSC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg11342453 chr6:26196699 NA 0.58 6.09 0.32 3.17e-9 Gout;Renal underexcretion gout; LUSC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg16928487 chr17:17741425 SREBF1 -0.33 -6.16 -0.32 2.11e-9 Total body bone mineral density; LUSC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -12.36 -0.56 3.64e-29 Type 2 diabetes; LUSC cis rs11971779 0.648 rs6946113 chr7:139106126 A/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 9.04 0.44 1.31e-17 Tonsillectomy; LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg26314531 chr2:26401878 FAM59B -0.59 -7.43 -0.38 8.92e-13 Gut microbiome composition (summer); LUSC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg11742103 chr11:62369870 EML3;MTA2 -0.46 -7.16 -0.36 5.02e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.75 0.39 1.08e-13 Bipolar disorder; LUSC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.87 0.44 4.57e-17 Menopause (age at onset); LUSC cis rs9379850 0.527 rs9393704 chr6:26358775 T/C cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Intelligence (multi-trait analysis); LUSC trans rs2797160 1.000 rs6910933 chr6:126017155 C/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.96 0.36 1.79e-11 Endometrial cancer; LUSC cis rs17685 0.625 rs1639630 chr7:75730499 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.69 -0.39 1.68e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg16339924 chr4:17578868 LAP3 0.52 7.83 0.39 6.34e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6701037 1.000 rs11580331 chr1:175123288 T/C cg17845761 chr1:175162550 KIAA0040 -0.32 -6.16 -0.32 2.06e-9 Alcohol dependence; LUSC trans rs17685 0.753 rs6976532 chr7:75681094 A/G cg19862616 chr7:65841803 NCRNA00174 1.07 19.25 0.73 4.4e-56 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1448094 0.802 rs11117146 chr12:86382870 C/T cg18827107 chr12:86230957 RASSF9 0.4 5.99 0.31 5.43e-9 Major depressive disorder; LUSC cis rs9303401 0.659 rs62081315 chr17:56781468 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg13010199 chr12:38710504 ALG10B 0.67 9.61 0.47 1.83e-19 Bladder cancer; LUSC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg12927641 chr6:109611667 NA -0.35 -5.88 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.11e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg25258033 chr6:167368657 RNASET2 0.43 7.1 0.36 7.59e-12 Crohn's disease; LUSC cis rs2777491 0.507 rs34040639 chr15:41760807 A/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -21.72 -0.77 7.36e-66 Ulcerative colitis; LUSC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11890956 chr21:40555474 PSMG1 -0.92 -16.66 -0.67 8.66e-46 Cognitive function; LUSC cis rs2439831 0.850 rs12442297 chr15:44168470 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.69 6.08 0.32 3.35e-9 Lung cancer in ever smokers; LUSC cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg24642439 chr20:33292090 TP53INP2 0.72 11.82 0.54 3.51e-27 Coronary artery disease; LUSC trans rs1325195 0.920 rs2793806 chr1:179180424 G/A cg11624085 chr17:8464688 MYH10 0.44 6.84 0.35 3.75e-11 IgE grass sensitization; LUSC cis rs4243830 1.000 rs12046884 chr1:6594561 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.97 9.47 0.46 5.31e-19 Body mass index; LUSC cis rs727505 0.954 rs28638102 chr7:124499480 A/C cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs7615952 0.546 rs11717632 chr3:125321130 G/C cg05084668 chr3:125655381 ALG1L -0.46 -5.91 -0.31 8.44e-9 Blood pressure (smoking interaction); LUSC cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg10426581 chr7:100472382 SRRT 0.82 12.36 0.56 3.58e-29 Resting heart rate; LUSC cis rs6060717 0.536 rs6060664 chr20:34478884 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.67 -0.3 3.14e-8 Hip circumference adjusted for BMI; LUSC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg03806693 chr22:41940476 POLR3H 0.99 14.03 0.61 1.78e-35 Vitiligo; LUSC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg22875332 chr1:76189707 ACADM 0.82 12.94 0.58 2.44e-31 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9807841 0.670 rs2738042 chr19:10790143 C/G cg17710535 chr19:10819994 QTRT1 0.41 6.6 0.34 1.66e-10 Inflammatory skin disease; LUSC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg07936489 chr17:37558343 FBXL20 0.65 8.35 0.42 1.87e-15 Glomerular filtration rate (creatinine); LUSC cis rs7937682 0.924 rs10891283 chr11:111527672 A/G cg19812747 chr11:111475976 SIK2 -0.48 -6.84 -0.35 3.87e-11 Primary sclerosing cholangitis; LUSC cis rs11190604 1.000 rs11190613 chr10:102313997 C/T cg23241863 chr10:102295624 HIF1AN -0.49 -6.08 -0.32 3.31e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs34293785 0.565 rs59710023 chr1:66137193 T/C cg04111102 chr1:66153794 NA 0.34 7.38 0.37 1.29e-12 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Sum basophil neutrophil counts;Neutrophil count;White blood cell count; LUSC cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.15 -0.36 5.58e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9560113 0.573 rs7988040 chr13:112226534 C/G cg10483660 chr13:112241077 NA 0.37 6.57 0.34 1.95e-10 Menarche (age at onset); LUSC cis rs4280164 0.945 rs2224122 chr14:24783414 G/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.6 -7.07 -0.36 9.32e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs9814567 0.806 rs4955525 chr3:134317008 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.76 -12.18 -0.55 1.73e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1577917 0.958 rs12213431 chr6:86500956 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.39 -0.42 1.34e-15 Response to antipsychotic treatment; LUSC cis rs6460942 0.591 rs4721080 chr7:12337785 T/C cg06484146 chr7:12443880 VWDE -0.58 -6.2 -0.32 1.67e-9 Coronary artery disease; LUSC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg07636037 chr3:49044803 WDR6 1.05 19.08 0.72 1.98e-55 Parkinson's disease; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.54 -7.29 -0.37 2.21e-12 Renal function-related traits (BUN); LUSC cis rs7804356 1.000 rs10272190 chr7:26887942 T/A cg03456212 chr7:26904342 SKAP2 -0.51 -5.91 -0.31 8.61e-9 Type 1 diabetes; LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg12432903 chr7:1882776 MAD1L1 -0.36 -5.82 -0.3 1.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg24675658 chr1:53192096 ZYG11B 0.58 9.07 0.44 1.01e-17 Monocyte count; LUSC cis rs61931739 0.513 rs10844698 chr12:33890158 C/T cg06521331 chr12:34319734 NA -0.36 -5.88 -0.31 1.02e-8 Morning vs. evening chronotype; LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 21.85 0.77 2.44e-66 Prudent dietary pattern; LUSC trans rs853679 0.607 rs200489 chr6:27798257 T/C cg01620082 chr3:125678407 NA -0.73 -7.34 -0.37 1.65e-12 Depression; LUSC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs12541635 0.966 rs2217391 chr8:107063126 A/G cg10147462 chr8:107024639 NA 0.57 10.46 0.5 2.36e-22 Age of smoking initiation; LUSC trans rs1751857 1.000 rs1782808 chr13:40976034 C/T cg24642820 chr3:13462465 NUP210 0.62 5.97 0.31 6.16e-9 Body mass index (change over time) in chronic obstructive pulmonary disease; LUSC cis rs2219968 1.000 rs35551201 chr8:78963968 G/A cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg16743903 chr16:89593216 SPG7 -0.47 -6.57 -0.34 1.88e-10 Multiple myeloma (IgH translocation); LUSC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.75 0.47 6.42e-20 Eosinophil percentage of white cells; LUSC cis rs7804356 0.954 rs3801815 chr7:26881292 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.58e-9 Type 1 diabetes; LUSC cis rs7107174 0.901 rs11237487 chr11:78126754 G/C cg27205649 chr11:78285834 NARS2 -0.52 -5.69 -0.3 2.85e-8 Testicular germ cell tumor; LUSC cis rs7647973 1.000 rs62261249 chr3:49594060 T/C cg07636037 chr3:49044803 WDR6 -0.66 -8.06 -0.4 1.4e-14 Menarche (age at onset); LUSC cis rs7917772 0.565 rs1043450 chr10:104434209 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.76 10.16 0.49 2.56e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg02428538 chr16:24856791 SLC5A11 -0.57 -6.3 -0.33 9.3e-10 Intelligence (multi-trait analysis); LUSC trans rs6598955 0.671 rs8564 chr1:26605069 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.53 -0.42 5.13e-16 Obesity-related traits; LUSC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC trans rs11098499 0.954 rs59866101 chr4:120296591 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.21e-9 Corneal astigmatism; LUSC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg20203395 chr5:56204925 C5orf35 -0.47 -7.04 -0.36 1.12e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs10504073 0.584 rs4873304 chr8:49922733 G/A cg00325661 chr8:49890786 NA 0.7 11.08 0.52 1.6e-24 Blood metabolite ratios; LUSC cis rs9616064 0.506 rs6008944 chr22:47060976 C/T cg25730555 chr22:47059586 GRAMD4 0.44 7.53 0.38 4.74e-13 Urate levels in obese individuals; LUSC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg16325326 chr1:53192061 ZYG11B -0.88 -16.04 -0.66 2.58e-43 Monocyte count; LUSC cis rs4363385 0.510 rs61811902 chr1:153053464 A/G cg25856811 chr1:152973957 SPRR3 -0.41 -6.64 -0.34 1.25e-10 Inflammatory skin disease; LUSC cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg22676075 chr6:135203613 NA 0.72 11.11 0.52 1.32e-24 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1865721 0.771 rs72975986 chr18:73127649 A/G cg26385618 chr18:73139727 C18orf62 -0.54 -9.7 -0.47 8.93e-20 Intelligence; LUSC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg08280861 chr8:58055591 NA -0.57 -6.22 -0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08889044 chr22:42949946 SERHL2 0.44 6.85 0.35 3.46e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg06028605 chr16:24865363 SLC5A11 0.5 8.62 0.43 2.69e-16 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19556208 chr14:24630405 IRF9 0.38 6.16 0.32 2.15e-9 Triglycerides; LUSC cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.82 0.68 1.93e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs9359856 0.564 rs72915918 chr6:90430792 G/C cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.68 -0.43 1.83e-16 Bipolar disorder; LUSC cis rs9547692 0.938 rs12427600 chr13:37460648 C/T cg01034396 chr13:37494802 SMAD9 -0.3 -5.79 -0.3 1.66e-8 Coronary artery disease; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -7.96 -0.4 2.67e-14 Lymphocyte counts; LUSC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg26314531 chr2:26401878 FAM59B -0.7 -9.2 -0.45 3.96e-18 Gut microbiome composition (summer); LUSC cis rs4930103 0.904 rs59121562 chr11:2025034 A/T cg06197492 chr11:2016605 H19 0.36 5.85 0.3 1.19e-8 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7577696 0.785 rs11683110 chr2:32349813 T/C cg02381751 chr2:32503542 YIPF4 -0.44 -6.22 -0.32 1.47e-9 Inflammatory biomarkers; LUSC cis rs72781680 0.752 rs56343114 chr2:23900629 C/G cg08917208 chr2:24149416 ATAD2B 0.85 8.96 0.44 2.37e-17 Lymphocyte counts; LUSC cis rs9300255 0.739 rs1533703 chr12:123742093 T/G cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.36 -0.33 6.57e-10 Neutrophil percentage of white cells; LUSC cis rs7312933 0.526 rs1669892 chr12:42811305 G/A cg01256987 chr12:42539512 GXYLT1 0.36 6.61 0.34 1.53e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10751667 0.666 rs4074234 chr11:977715 C/G ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.3e-10 Alzheimer's disease (late onset); LUSC cis rs10089 1.000 rs2409109 chr5:127461471 C/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.65 -0.3 3.46e-8 Ileal carcinoids; LUSC trans rs8073060 0.559 rs10438814 chr17:34007065 A/G cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.44 0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg07395648 chr5:131743802 NA 0.39 6.24 0.32 1.32e-9 Asthma (sex interaction); LUSC cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg21535247 chr6:8435926 SLC35B3 0.58 9.05 0.44 1.22e-17 Motion sickness; LUSC cis rs1080500 1.000 rs1080500 chr3:53175017 C/T cg18404041 chr3:52824283 ITIH1 -0.45 -7.51 -0.38 5.29e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg06112835 chr11:68658793 MRPL21 0.51 7.71 0.39 1.47e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6554196 0.508 rs3819386 chr4:55527374 T/C cg18836493 chr4:55524333 KIT -0.44 -7.6 -0.38 3e-13 Monocyte count; LUSC cis rs2354432 0.607 rs68080346 chr1:146708484 T/C cg25205988 chr1:146714368 CHD1L -1.01 -8.99 -0.44 1.91e-17 Mitochondrial DNA levels; LUSC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.7 0.3 2.67e-8 Cerebrospinal P-tau181p levels; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg21280719 chr6:42927975 GNMT 0.3 7.52 0.38 5.18e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9790314 1.000 rs336548 chr3:161058412 T/C cg04691961 chr3:161091175 C3orf57 -0.35 -6.11 -0.32 2.74e-9 Morning vs. evening chronotype; LUSC cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg22709100 chr7:91322751 NA 0.4 5.77 0.3 1.8e-8 Breast cancer; LUSC cis rs1595825 0.891 rs60582020 chr2:198520555 A/C cg19156104 chr2:198669113 PLCL1 -0.45 -5.69 -0.3 2.74e-8 Ulcerative colitis; LUSC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg06008330 chr7:65541103 ASL -0.4 -6.27 -0.32 1.13e-9 Aortic root size; LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg07700843 chr1:2391317 NA -0.36 -6.37 -0.33 6.16e-10 Schizophrenia; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg06873352 chr17:61820015 STRADA 0.71 12.79 0.57 9.66e-31 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.94e-10 Menopause (age at onset); LUSC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg05340658 chr4:99064831 C4orf37 -0.64 -10.99 -0.52 3.58e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg24531977 chr5:56204891 C5orf35 -1.08 -15.78 -0.65 2.71e-42 Initial pursuit acceleration; LUSC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg06618935 chr21:46677482 NA -0.39 -7.74 -0.39 1.16e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg06221963 chr1:154839813 KCNN3 -0.59 -12.99 -0.58 1.61e-31 Prostate cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13560760 chr9:139308792 PMPCA -0.43 -6.93 -0.35 2.12e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1355223 0.583 rs2956074 chr11:34864880 T/C cg11058730 chr11:34937778 PDHX;APIP 0.69 11.25 0.52 4.26e-25 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9467711 0.651 rs16891261 chr6:26062631 A/G cg08501292 chr6:25962987 TRIM38 0.66 6.05 0.31 3.97e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs1030877 0.515 rs2576735 chr2:105888839 C/T cg02079111 chr2:105885981 TGFBRAP1 0.64 8.56 0.42 4.17e-16 Obesity-related traits; LUSC cis rs6831352 0.879 rs4699717 chr4:100066137 C/T cg13256891 chr4:100009986 ADH5 -0.49 -6.37 -0.33 6.11e-10 Alcohol dependence; LUSC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg18758796 chr5:131593413 PDLIM4 0.43 7.46 0.38 7.59e-13 Breast cancer; LUSC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg24110177 chr3:50126178 RBM5 -0.54 -8.8 -0.43 7.39e-17 Intelligence (multi-trait analysis); LUSC cis rs8044995 0.563 rs56899435 chr16:68395675 G/A cg09835421 chr16:68378352 PRMT7 -0.75 -8.25 -0.41 3.72e-15 Schizophrenia; LUSC trans rs11098499 0.754 rs28652763 chr4:120242312 C/T cg25214090 chr10:38739885 LOC399744 0.43 6.58 0.34 1.77e-10 Corneal astigmatism; LUSC cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg12365402 chr11:9010492 NRIP3 -0.39 -6.73 -0.35 7.19e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs1577917 1.000 rs12201735 chr6:86656939 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.46 -0.42 8.33e-16 Response to antipsychotic treatment; LUSC cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg07148914 chr20:33460835 GGT7 -0.55 -8.41 -0.42 1.25e-15 Height; LUSC cis rs10911363 0.592 rs2702177 chr1:183450622 G/C cg09173681 chr1:183549694 NCF2 0.66 12.24 0.56 1.08e-28 Systemic lupus erythematosus; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg19318889 chr4:1322082 MAEA 0.42 7.02 0.36 1.26e-11 Obesity-related traits; LUSC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg20243544 chr17:37824526 PNMT 0.47 5.97 0.31 5.98e-9 Glomerular filtration rate (creatinine); LUSC cis rs7197653 0.748 rs61460037 chr16:68336125 A/C cg09835421 chr16:68378352 PRMT7 -0.73 -7.63 -0.39 2.43e-13 Magnesium levels; LUSC cis rs9467773 0.595 rs2172007 chr6:26639777 A/C cg11502198 chr6:26597334 ABT1 0.69 11.45 0.53 7.68e-26 Intelligence (multi-trait analysis); LUSC cis rs11785400 1.000 rs10108059 chr8:143750028 G/T cg10596483 chr8:143751796 JRK -0.6 -9.22 -0.45 3.54e-18 Schizophrenia; LUSC cis rs2439831 0.681 rs498837 chr15:43608024 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.11 15.85 0.66 1.44e-42 Lung cancer in ever smokers; LUSC cis rs11779988 0.545 rs208753 chr8:17814915 A/G cg01800426 chr8:17659068 MTUS1 -0.47 -5.74 -0.3 2.13e-8 Breast cancer; LUSC cis rs10088262 0.629 rs12549683 chr8:124798276 G/C cg20713898 chr8:124780851 FAM91A1 -0.54 -7.52 -0.38 5.18e-13 Pancreatic cancer; LUSC cis rs877282 0.755 rs2486579 chr10:785647 G/A cg17470449 chr10:769945 NA 0.41 6.03 0.31 4.33e-9 Uric acid levels; LUSC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg12927641 chr6:109611667 NA -0.43 -7.62 -0.38 2.71e-13 Reticulocyte fraction of red cells; LUSC cis rs826838 0.616 rs2200605 chr12:38624088 G/A cg26384229 chr12:38710491 ALG10B 0.58 8.66 0.43 2.11e-16 Heart rate; LUSC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.14 -0.36 5.69e-12 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg23711669 chr6:146136114 FBXO30 0.88 16.13 0.66 1.05e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.577 rs940032 chr8:8546343 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.95 -0.36 1.97e-11 Mood instability; LUSC cis rs9420 0.961 rs1647405 chr11:57477889 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -8.13 -0.41 8.55e-15 Schizophrenia; LUSC cis rs4588572 0.643 rs10942857 chr5:77760241 A/G cg11547950 chr5:77652471 NA -0.56 -7.9 -0.4 4.03e-14 Triglycerides; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15152706 chr6:170615451 FAM120B -0.4 -6.18 -0.32 1.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg11266682 chr4:10021025 SLC2A9 0.52 9.51 0.46 3.79e-19 Bone mineral density; LUSC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.38 -0.33 5.88e-10 Lung cancer; LUSC cis rs17270561 0.666 rs4712976 chr6:25842203 C/T cg16482183 chr6:26056742 HIST1H1C 0.58 8.27 0.41 3.26e-15 Iron status biomarkers; LUSC cis rs7617480 0.558 rs12715430 chr3:48942855 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.76 0.47 5.69e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg16434002 chr17:42200994 HDAC5 -0.46 -6.44 -0.33 4.27e-10 Total body bone mineral density; LUSC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg15664640 chr17:80829946 TBCD 0.47 8.44 0.42 9.53e-16 Breast cancer; LUSC cis rs12410462 0.502 rs78101727 chr1:227732069 C/T cg23173402 chr1:227635558 NA 0.68 6.57 0.34 1.93e-10 Major depressive disorder; LUSC trans rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.74 -13.39 -0.59 4.85e-33 Brugada syndrome; LUSC cis rs977987 0.806 rs7188604 chr16:75451170 T/G cg03315344 chr16:75512273 CHST6 0.48 8.91 0.44 3.47e-17 Dupuytren's disease; LUSC cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg05340658 chr4:99064831 C4orf37 0.69 11.84 0.54 2.99e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.47 -8.79 -0.43 7.93e-17 Monocyte percentage of white cells; LUSC trans rs3733585 0.699 rs7686538 chr4:9948077 C/T cg26043149 chr18:55253948 FECH -0.45 -6.85 -0.35 3.53e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2635047 0.811 rs9965170 chr18:44788274 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.71 0.3 2.47e-8 Educational attainment; LUSC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg02569458 chr12:86230093 RASSF9 0.48 7.57 0.38 3.66e-13 Major depressive disorder; LUSC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs8072100 0.745 rs7214410 chr17:45422628 A/G cg04995722 chr7:26192034 NFE2L3 -0.38 -6.02 -0.31 4.49e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7177699 0.557 rs8026598 chr15:79112938 A/G cg00540400 chr15:79124168 NA 0.45 8.06 0.4 1.41e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1983170 0.808 rs6668067 chr1:92018613 G/A cg25838465 chr1:92012736 NA 0.42 5.92 0.31 7.87e-9 Eosinophil percentage of white cells; LUSC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg20406979 chr6:167373233 NA 0.26 6.21 0.32 1.61e-9 Crohn's disease; LUSC cis rs6445967 0.569 rs7622497 chr3:58282673 A/C cg13750441 chr3:58318267 PXK -0.32 -5.65 -0.3 3.38e-8 Platelet count; LUSC trans rs6582630 0.519 rs4294627 chr12:38293982 C/T cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg07677032 chr17:61819896 STRADA 0.54 9.05 0.44 1.17e-17 Prudent dietary pattern; LUSC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg02782426 chr3:40428986 ENTPD3 0.32 6.06 0.31 3.72e-9 Renal cell carcinoma; LUSC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg06634786 chr22:41940651 POLR3H -0.56 -6.52 -0.34 2.61e-10 Vitiligo; LUSC cis rs73416724 1.000 rs75320251 chr6:43395101 G/A cg26312998 chr6:43337775 ZNF318 0.56 6.67 0.34 1.09e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs73198271 0.694 rs115037021 chr8:8647080 A/C cg01851573 chr8:8652454 MFHAS1 0.52 8.12 0.41 9.04e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17155006 0.664 rs410866 chr7:107744543 C/T cg05962710 chr7:107745446 LAMB4 0.34 5.87 0.31 1.03e-8 Pneumococcal bacteremia; LUSC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg19257562 chr1:2043853 PRKCZ 0.31 6.06 0.31 3.73e-9 Height; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg03354898 chr7:1950403 MAD1L1 -0.35 -6.88 -0.35 2.94e-11 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg08470875 chr2:26401718 FAM59B -0.68 -8.85 -0.44 5.2e-17 Gut microbiome composition (summer); LUSC cis rs7503807 0.967 rs12939549 chr17:78611724 C/T cg09596252 chr17:78655493 RPTOR -0.45 -7.65 -0.39 2.15e-13 Obesity; LUSC cis rs7818345 0.845 rs11782540 chr8:19268251 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 6.16 0.32 2.1e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs561341 0.629 rs7216107 chr17:30224419 G/A cg00745463 chr17:30367425 LRRC37B -0.47 -6.68 -0.34 1.01e-10 Hip circumference adjusted for BMI; LUSC cis rs4268898 0.717 rs2543662 chr2:24443271 G/T cg06627628 chr2:24431161 ITSN2 0.81 12.16 0.55 2.08e-28 Asthma; LUSC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.98 15.22 0.64 4.35e-40 Platelet count; LUSC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg26695010 chr11:65641043 EFEMP2 -0.47 -7.09 -0.36 8.12e-12 Eosinophil percentage of white cells; LUSC cis rs7264396 0.563 rs2425119 chr20:34324216 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.38 -0.42 1.49e-15 Total cholesterol levels; LUSC cis rs7106204 0.514 rs1443043 chr11:24251991 A/G ch.11.24196551F chr11:24239977 NA 0.92 10.2 0.49 1.98e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs61931739 0.817 rs304313 chr12:34216898 C/T cg06521331 chr12:34319734 NA -0.37 -6.37 -0.33 6.39e-10 Morning vs. evening chronotype; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg20205542 chr3:183892600 AP2M1 0.46 6.3 0.33 9.17e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1595825 1.000 rs6434950 chr2:198869979 A/G cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs9790314 1.000 rs336577 chr3:161066294 C/T cg03342759 chr3:160939853 NMD3 -0.49 -8.21 -0.41 4.95e-15 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg07362569 chr17:61921086 SMARCD2 0.37 7.67 0.39 1.92e-13 Prudent dietary pattern; LUSC cis rs965513 1.000 rs1588635 chr9:100537802 A/C cg13688889 chr9:100608707 NA -0.63 -9.42 -0.46 7.83e-19 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs847577 0.748 rs940432 chr7:97716483 G/A cg21770322 chr7:97807741 LMTK2 0.5 8.59 0.43 3.5e-16 Breast cancer; LUSC trans rs11098499 0.913 rs68128210 chr4:120137819 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.23 0.32 1.39e-9 Corneal astigmatism; LUSC cis rs1941023 0.503 rs10750936 chr11:60144180 G/A cg08716584 chr11:60157161 MS4A7 -0.65 -12.39 -0.56 2.92e-29 Congenital heart disease (maternal effect); LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg01238044 chr22:24384105 GSTT1 -0.53 -7.35 -0.37 1.55e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs116095464 0.558 rs28636067 chr5:199415 G/A cg22496380 chr5:211416 CCDC127 -0.86 -8.69 -0.43 1.6e-16 Breast cancer; LUSC cis rs3849570 1.000 rs9826270 chr3:81841869 C/T cg07356753 chr3:81810745 GBE1 -0.69 -11.09 -0.52 1.51e-24 Waist circumference;Body mass index; LUSC cis rs4629710 0.592 rs9492877 chr6:131562577 C/G cg12606694 chr6:131520996 AKAP7 0.62 9.42 0.46 7.5e-19 Multiple myeloma (IgH translocation); LUSC trans rs10506458 1.000 rs11174759 chr12:63444363 A/T cg22491629 chr6:157744540 C6orf35 -0.9 -10.67 -0.5 4.68e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs2732480 0.538 rs2732462 chr12:48696384 A/G cg04545296 chr12:48745243 ZNF641 0.35 6.38 0.33 6.03e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs10865541 0.902 rs12476309 chr2:3404845 C/T cg15807143 chr2:3452624 TTC15 0.32 5.67 0.3 3.11e-8 Obesity-related traits; LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.78 0.43 8.48e-17 Prudent dietary pattern; LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg08736216 chr1:53307985 ZYG11A 0.3 6.16 0.32 2.04e-9 Monocyte count; LUSC cis rs295140 0.706 rs1347551 chr2:201186572 C/T cg04283868 chr2:201171347 SPATS2L 0.4 5.65 0.3 3.45e-8 QT interval; LUSC cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg23788917 chr6:8435910 SLC35B3 -0.48 -6.99 -0.36 1.49e-11 Motion sickness; LUSC cis rs6542838 0.611 rs17758170 chr2:99531842 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.53 -7.07 -0.36 9.1e-12 Fear of minor pain; LUSC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC trans rs1908814 0.503 rs34657250 chr8:11795373 A/G cg27411982 chr8:10470053 RP1L1 -0.44 -6.83 -0.35 4.08e-11 Neuroticism; LUSC cis rs2777491 0.507 rs11854081 chr15:41646398 C/T cg18705301 chr15:41695430 NDUFAF1 -1.06 -24.08 -0.8 5.54e-75 Ulcerative colitis; LUSC trans rs7829975 0.742 rs882462 chr8:8678530 G/A cg27411982 chr8:10470053 RP1L1 0.41 6.28 0.32 1.08e-9 Mood instability; LUSC cis rs7107174 1.000 rs6592772 chr11:78015563 A/C cg02023728 chr11:77925099 USP35 0.48 6.73 0.35 7.42e-11 Testicular germ cell tumor; LUSC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg23985595 chr17:80112537 CCDC57 -0.3 -5.68 -0.3 2.87e-8 Life satisfaction; LUSC cis rs12986413 1.000 rs12986413 chr19:2170954 A/T cg09261902 chr19:2140048 AP3D1 -0.32 -6.3 -0.33 9.48e-10 Height; LUSC cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg13319975 chr6:146136371 FBXO30 0.49 7.53 0.38 4.85e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9395066 0.527 rs1590864 chr6:44906151 C/A cg25276700 chr6:44698697 NA 0.3 6.07 0.32 3.46e-9 Height; LUSC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg06287003 chr12:125626642 AACS -0.41 -6.8 -0.35 4.79e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9300255 0.722 rs12304248 chr12:123810425 C/T cg00376283 chr12:123451042 ABCB9 -0.66 -7.74 -0.39 1.18e-13 Neutrophil percentage of white cells; LUSC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg20503657 chr10:835505 NA 1.0 13.96 0.61 3.22e-35 Eosinophil percentage of granulocytes; LUSC cis rs1044826 0.642 rs9859864 chr3:139091219 G/T cg00490450 chr3:139108681 COPB2 -0.51 -8.14 -0.41 7.74e-15 Obesity-related traits; LUSC cis rs7527798 0.501 rs12125256 chr1:207851361 C/T cg09232269 chr1:207846808 CR1L -0.29 -6.27 -0.32 1.14e-9 Erythrocyte sedimentation rate; LUSC trans rs12579753 0.827 rs7958100 chr12:82200782 G/A cg07923666 chr12:49932857 KCNH3 -0.49 -6.14 -0.32 2.29e-9 Resting heart rate; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg19230755 chr7:65878503 NA -0.4 -5.75 -0.3 2.06e-8 Aortic root size; LUSC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg05340658 chr4:99064831 C4orf37 0.59 9.73 0.47 7.5e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs877282 0.898 rs11253341 chr10:765008 G/C cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.62 -0.34 1.41e-10 Lung cancer; LUSC cis rs9814567 1.000 rs4974493 chr3:134219993 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.81 -0.6 1.26e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg14092988 chr3:52407081 DNAH1 0.32 5.9 0.31 8.93e-9 Bipolar disorder; LUSC cis rs11166629 1.000 rs894349 chr8:135638055 T/C cg21672855 chr8:135614777 ZFAT 0.36 5.91 0.31 8.3e-9 Smoking quantity; LUSC cis rs73206853 0.686 rs73206895 chr12:110879968 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9467711 0.606 rs9393710 chr6:26367833 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs1728785 1.000 rs1170436 chr16:68607486 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.94 0.4 3.18e-14 Ulcerative colitis; LUSC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg12963246 chr6:28129442 ZNF389 0.39 6.07 0.32 3.54e-9 Cardiac Troponin-T levels; LUSC cis rs992157 1.000 rs2292553 chr2:219146803 G/A cg00012203 chr2:219082015 ARPC2 0.82 14.46 0.62 3.99e-37 Colorectal cancer; LUSC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg02269571 chr22:50332266 NA 0.6 8.97 0.44 2.25e-17 Schizophrenia; LUSC trans rs11098499 0.955 rs4145951 chr4:120155817 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1595825 0.786 rs77773624 chr2:198514845 G/A cg19156104 chr2:198669113 PLCL1 -0.46 -5.84 -0.3 1.24e-8 Ulcerative colitis; LUSC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.863 rs2170276 chr4:120485824 A/C cg24375607 chr4:120327624 NA 0.75 11.09 0.52 1.57e-24 Corneal astigmatism; LUSC cis rs7829975 0.582 rs11783950 chr8:8597831 A/C cg06636001 chr8:8085503 FLJ10661 -0.53 -7.61 -0.38 2.74e-13 Mood instability; LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg14784868 chr12:69753453 YEATS4 0.84 14.2 0.61 3.93e-36 Blood protein levels; LUSC cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs7216064 1.000 rs7216064 chr17:65898809 G/A cg12091567 chr17:66097778 LOC651250 -0.71 -9.45 -0.46 6.25e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg25208724 chr1:156163844 SLC25A44 1.05 17.93 0.7 8.17e-51 Testicular germ cell tumor; LUSC cis rs4363385 0.740 rs1338181 chr1:153010301 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.2 -0.37 4.14e-12 Inflammatory skin disease; LUSC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg08270630 chr22:50330655 NA 0.4 5.9 0.31 8.78e-9 Schizophrenia; LUSC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg16797656 chr11:68205561 LRP5 0.37 6.7 0.34 9e-11 Total body bone mineral density; LUSC trans rs6952808 0.692 rs11765549 chr7:2027311 G/T cg04565464 chr8:145669602 NFKBIL2 0.4 6.53 0.34 2.44e-10 Bipolar disorder and schizophrenia; LUSC trans rs1728785 0.901 rs6499186 chr16:68660565 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 8.03 0.4 1.7e-14 Ulcerative colitis; LUSC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg00129232 chr17:37814104 STARD3 -0.49 -7.32 -0.37 1.84e-12 Asthma; LUSC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Parkinson's disease; LUSC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg15704280 chr7:45808275 SEPT13 -1.02 -19.52 -0.73 3.57e-57 Height; LUSC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg03806693 chr22:41940476 POLR3H 1.01 14.1 0.61 9.46e-36 Vitiligo; LUSC cis rs7953249 0.807 rs7970695 chr12:121423376 G/A cg02403541 chr12:121454288 C12orf43 -0.62 -9.08 -0.44 9.97e-18 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs977987 0.872 rs4887825 chr16:75472422 C/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.11 -0.36 6.95e-12 Dupuytren's disease; LUSC cis rs12618769 0.597 rs17031146 chr2:99036683 A/G cg10123293 chr2:99228465 UNC50 0.46 7.73 0.39 1.27e-13 Bipolar disorder; LUSC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg15110403 chr19:17392923 ANKLE1 -0.58 -7.97 -0.4 2.57e-14 Systemic lupus erythematosus; LUSC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg22823121 chr1:150693482 HORMAD1 0.49 7.2 0.37 4.13e-12 Melanoma; LUSC cis rs1568889 0.712 rs10835306 chr11:28302410 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 13.11 0.58 5.78e-32 Bipolar disorder; LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 16.05 0.66 2.26e-43 Platelet count; LUSC cis rs59698941 0.943 rs73259116 chr5:132218461 A/G cg02081065 chr5:132209139 LEAP2 -0.65 -6.76 -0.35 6.04e-11 Apolipoprotein A-IV levels; LUSC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg13918804 chr1:2043761 PRKCZ 0.27 5.81 0.3 1.48e-8 Height; LUSC trans rs7819412 0.521 rs9329238 chr8:11033737 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.16 -0.32 2.15e-9 Triglycerides; LUSC cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.44 6.11 0.32 2.72e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1018836 0.632 rs2879361 chr8:91481909 C/T cg16814680 chr8:91681699 NA 0.67 10.17 0.49 2.46e-21 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg15839431 chr19:19639596 YJEFN3 0.42 5.73 0.3 2.3e-8 Tonsillectomy; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.4 -0.38 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2190422 0.651 rs6945055 chr7:103086835 T/G cg04218035 chr7:103086829 SLC26A5 0.31 6.08 0.32 3.21e-9 Morning vs. evening chronotype; LUSC cis rs10782582 0.609 rs80059220 chr1:76279112 G/T cg10523679 chr1:76189770 ACADM -0.48 -6.99 -0.36 1.48e-11 Daytime sleep phenotypes; LUSC cis rs7267979 0.933 rs2387887 chr20:25427081 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1395 0.744 rs3739092 chr2:27462076 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.25 0.37 2.85e-12 Blood metabolite levels; LUSC cis rs612683 0.824 rs17454919 chr1:100830370 A/G cg06223162 chr1:101003688 GPR88 0.4 7.31 0.37 2.05e-12 Breast cancer; LUSC cis rs11792861 0.926 rs7856626 chr9:111775502 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.6 9.02 0.44 1.51e-17 Menarche (age at onset); LUSC cis rs9467711 0.606 rs67234939 chr6:26530419 A/G cg09904177 chr6:26538194 HMGN4 -0.73 -6.67 -0.34 1.05e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg24562669 chr7:97807699 LMTK2 0.4 6.78 0.35 5.32e-11 Breast cancer; LUSC cis rs61931739 0.534 rs11052960 chr12:33997754 A/T cg06521331 chr12:34319734 NA -0.46 -7.33 -0.37 1.73e-12 Morning vs. evening chronotype; LUSC cis rs17401966 1.000 rs12130220 chr1:10359944 T/G cg19773385 chr1:10388646 KIF1B -0.54 -8.33 -0.41 2.08e-15 Hepatocellular carcinoma; LUSC cis rs7681440 0.804 rs1442135 chr4:90819093 C/T cg01966878 chr4:90757139 SNCA 0.33 5.69 0.3 2.73e-8 Dementia with Lewy bodies; LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg04518342 chr5:131593106 PDLIM4 0.53 9.79 0.47 4.47e-20 Acylcarnitine levels; LUSC cis rs1568889 0.838 rs11030220 chr11:28145769 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.7 0.57 2.01e-30 Bipolar disorder; LUSC cis rs9311676 0.656 rs56097407 chr3:58378079 G/A cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg06600287 chr1:53387719 ECHDC2 -0.28 -5.69 -0.3 2.71e-8 Monocyte count; LUSC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg22823121 chr1:150693482 HORMAD1 0.56 8.46 0.42 8.54e-16 Melanoma; LUSC cis rs9300255 0.602 rs1716168 chr12:123651966 C/G cg00376283 chr12:123451042 ABCB9 -0.66 -8.39 -0.42 1.4e-15 Neutrophil percentage of white cells; LUSC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg13939156 chr17:80058883 NA -0.33 -6.42 -0.33 4.68e-10 Life satisfaction; LUSC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.59 -0.38 3.15e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs11048434 0.736 rs1805761 chr12:9099533 T/C cg13575925 chr12:9217583 LOC144571 0.34 6.25 0.32 1.29e-9 Sjögren's syndrome; LUSC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg03477792 chr4:77819574 ANKRD56 0.61 8.7 0.43 1.52e-16 Emphysema distribution in smoking; LUSC cis rs7091068 0.566 rs7909925 chr10:95507170 A/G cg20715218 chr10:95462985 C10orf4 0.59 6.53 0.34 2.48e-10 Urinary tract infection frequency; LUSC cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.95 12.23 0.56 1.1e-28 Chronic sinus infection; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg18864399 chr15:73345368 NEO1 0.39 5.96 0.31 6.31e-9 Calcium levels; LUSC cis rs2294693 0.945 rs11756893 chr6:41010058 A/C cg14769373 chr6:40998127 UNC5CL -0.54 -7.22 -0.37 3.59e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg05855489 chr10:104503620 C10orf26 0.6 9.44 0.46 6.77e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg14895029 chr7:2775587 GNA12 -0.41 -6.13 -0.32 2.53e-9 Height; LUSC cis rs11098499 0.739 rs2203039 chr4:120132347 T/C cg09307838 chr4:120376055 NA -0.59 -8.76 -0.43 9.86e-17 Corneal astigmatism; LUSC cis rs10927875 0.632 rs7535248 chr1:16129598 C/T cg21385522 chr1:16154831 NA -0.98 -18.46 -0.71 6.21e-53 Dilated cardiomyopathy; LUSC cis rs57504626 1 rs57504626 chr19:19720399 C/T cg03709012 chr19:19516395 GATAD2A 0.88 7.15 0.36 5.53e-12 Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg05776053 chr2:74358815 NA 0.45 7.21 0.37 3.77e-12 Gestational age at birth (maternal effect); LUSC cis rs4631830 0.720 rs12412140 chr10:51503977 T/C cg20129853 chr10:51489980 NA 0.36 7.45 0.38 7.84e-13 Prostate-specific antigen levels; LUSC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg00810483 chr4:3375144 RGS12 -0.31 -6.1 -0.32 2.9e-9 Serum sulfate level; LUSC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg09365446 chr1:150670422 GOLPH3L 0.46 6.93 0.35 2.16e-11 Melanoma; LUSC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg25036284 chr2:26402008 FAM59B -0.68 -9.38 -0.46 1.06e-18 Gut microbiome composition (summer); LUSC cis rs7712401 0.623 rs538424 chr5:122228763 G/A cg19077854 chr5:122220652 SNX24 0.39 8.64 0.43 2.36e-16 Mean platelet volume; LUSC cis rs4566357 0.930 rs13398295 chr2:227926873 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.89 -0.31 9.43e-9 Coronary artery disease; LUSC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg21644426 chr2:191273491 MFSD6 0.61 9.72 0.47 8e-20 Pulse pressure; LUSC cis rs2708377 0.929 rs2599415 chr12:11217237 G/A cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs3820928 0.874 rs13423046 chr2:227901805 G/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.89 -0.4 4.48e-14 Pulmonary function; LUSC trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg03929089 chr4:120376271 NA -0.6 -7.24 -0.37 3.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg23711669 chr6:146136114 FBXO30 0.93 18.04 0.7 2.89e-51 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13266717 chr20:62338881 ARFRP1;ZGPAT -0.43 -6.5 -0.34 2.95e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs8072100 0.905 rs11651766 chr17:45574931 G/T cg03886242 chr7:26192032 NFE2L3 -0.38 -6.23 -0.32 1.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9650315 0.866 rs6474053 chr8:57169733 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg12365402 chr11:9010492 NRIP3 -0.4 -6.81 -0.35 4.53e-11 Hemoglobin concentration; LUSC cis rs7091068 0.522 rs866674 chr10:95487515 A/G cg20715218 chr10:95462985 C10orf4 0.61 7.51 0.38 5.6e-13 Urinary tract infection frequency; LUSC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg02896835 chr1:92012615 NA -0.62 -11.13 -0.52 1.08e-24 Breast cancer; LUSC cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg06547715 chr2:218990976 CXCR2 0.33 6.52 0.34 2.63e-10 Ulcerative colitis; LUSC cis rs7940866 0.740 rs7131121 chr11:130806424 A/G cg12179176 chr11:130786555 SNX19 0.64 9.55 0.46 2.87e-19 Schizophrenia; LUSC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg04800585 chr6:26043546 HIST1H2BB 0.4 5.83 0.3 1.33e-8 Intelligence (multi-trait analysis); LUSC trans rs8022206 0.891 rs1033686 chr14:68362510 A/G cg15809352 chr2:121748218 GLI2 -0.44 -6.29 -0.33 9.84e-10 Platelet count;Mean platelet volume; LUSC cis rs3741151 0.773 rs73544729 chr11:73183418 G/T cg17517138 chr11:73019481 ARHGEF17 0.99 8.33 0.41 2.14e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg09655341 chr17:79618100 PDE6G -0.27 -6.12 -0.32 2.64e-9 Eye color traits; LUSC cis rs10872587 0.657 rs11155459 chr6:146578751 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -7.11 -0.36 6.93e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs7824557 0.564 rs2736290 chr8:11234298 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.28 -0.32 1.06e-9 Retinal vascular caliber; LUSC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg11764359 chr7:65958608 NA -0.68 -10.44 -0.5 2.84e-22 Aortic root size; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -12.61 -0.57 4.42e-30 Alzheimer's disease; LUSC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg03264133 chr6:25882463 NA -0.47 -7.92 -0.4 3.47e-14 Intelligence (multi-trait analysis); LUSC cis rs4919694 0.901 rs79331374 chr10:104882913 G/A cg04362960 chr10:104952993 NT5C2 1.16 13.95 0.61 3.69e-35 Arsenic metabolism; LUSC cis rs6696846 0.749 rs7553876 chr1:205079915 A/G cg21643547 chr1:205240462 TMCC2 -0.38 -7.04 -0.36 1.11e-11 Red blood cell count; LUSC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg00484396 chr16:3507460 NAT15 0.49 7.23 0.37 3.26e-12 Body mass index (adult); LUSC cis rs6681460 0.565 rs1536112 chr1:67107225 C/T cg02459107 chr1:67143332 SGIP1 -0.44 -8.27 -0.41 3.16e-15 Presence of antiphospholipid antibodies; LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg05025164 chr4:1340916 KIAA1530 0.65 10.57 0.5 9.85e-23 Longevity; LUSC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs2204008 0.694 rs10880262 chr12:38328696 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.79 0.51 1.7e-23 Bladder cancer; LUSC cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.08 20.92 0.75 1.06e-62 Cognitive ability; LUSC cis rs7580658 0.963 rs867304 chr2:128078488 G/A cg09760422 chr2:128146352 NA -0.32 -7.24 -0.37 3.13e-12 Protein C levels; LUSC cis rs61931739 0.500 rs11053223 chr12:34481947 T/A cg06521331 chr12:34319734 NA -0.41 -6.43 -0.33 4.4e-10 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs921968 0.565 rs6436073 chr2:219618237 A/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.03 -0.48 7.16e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.75 7.49 0.38 6.31e-13 Initial pursuit acceleration; LUSC cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg17509989 chr5:176798049 RGS14 0.69 10.99 0.52 3.4e-24 Hemoglobin concentration;Hematocrit; LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg03188948 chr7:1209495 NA 0.64 6.9 0.35 2.56e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg23788917 chr6:8435910 SLC35B3 0.48 7.2 0.37 4.1e-12 Motion sickness; LUSC cis rs12042938 0.600 rs823161 chr1:231775017 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 6.13 0.32 2.43e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg13047869 chr3:10149882 C3orf24 0.57 7.91 0.4 3.81e-14 Alzheimer's disease; LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.4 0.56 2.7e-29 Prudent dietary pattern; LUSC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg14019146 chr3:50243930 SLC38A3 0.31 6.78 0.35 5.6e-11 Intelligence (multi-trait analysis); LUSC cis rs6981523 0.553 rs11783045 chr8:11056175 A/G cg21775007 chr8:11205619 TDH -0.49 -6.6 -0.34 1.6e-10 Neuroticism; LUSC cis rs9914988 0.943 rs9913801 chr17:27132105 G/A cg09479241 chr17:27052676 TLCD1 0.44 5.9 0.31 8.93e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg10802521 chr3:52805072 NEK4 -0.55 -8.98 -0.44 2.02e-17 Bipolar disorder; LUSC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg03609598 chr5:56110824 MAP3K1 -0.42 -5.97 -0.31 5.96e-9 Initial pursuit acceleration; LUSC cis rs7804356 1.000 rs10272603 chr7:26888277 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC trans rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.74 -13.47 -0.59 2.5e-33 Brugada syndrome; LUSC trans rs724744 0.772 rs1629125 chr6:22353431 A/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.19 -0.32 1.77e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs9650657 0.836 rs3905581 chr8:10603705 G/T cg14992524 chr8:10586135 SOX7 -0.3 -5.65 -0.3 3.39e-8 Neuroticism; LUSC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg20135002 chr11:47629003 NA -0.49 -7.66 -0.39 2.06e-13 Subjective well-being; LUSC cis rs4561483 0.801 rs33660 chr16:11961858 A/G cg08843971 chr16:11963173 GSPT1 -0.49 -7.59 -0.38 3.31e-13 Testicular germ cell tumor; LUSC cis rs1003719 0.788 rs2835578 chr21:38457671 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.46 0.53 7.16e-26 Eye color traits; LUSC cis rs11958404 0.932 rs72816600 chr5:157436349 T/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs116988415 0.584 rs11622171 chr14:65258644 C/G cg25083366 chr14:65239357 SPTB 0.68 6.83 0.35 4.1e-11 Daytime sleep phenotypes; LUSC cis rs9303401 0.659 rs62081316 chr17:56781499 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg17279839 chr7:150038598 RARRES2 0.41 6.39 0.33 5.56e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs11122272 0.735 rs2572254 chr1:231512593 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.85 -0.47 2.99e-20 Hemoglobin concentration; LUSC cis rs7949030 1.000 rs2956993 chr11:62406162 G/T cg13298116 chr11:62369859 EML3;MTA2 -0.51 -8.74 -0.43 1.18e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8072100 0.967 rs4239163 chr17:45755954 C/T cg25173405 chr17:45401733 C17orf57 -0.38 -6.03 -0.31 4.27e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7917772 0.510 rs2001389 chr10:104375258 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.08 0.52 1.68e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg06238570 chr21:40685208 BRWD1 -0.55 -8.63 -0.43 2.55e-16 Menarche (age at onset); LUSC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.02 0.36 1.27e-11 Mean platelet volume; LUSC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.36 -0.69 1.44e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg00334542 chr7:100209784 MOSPD3 -0.48 -5.7 -0.3 2.61e-8 Other erythrocyte phenotypes; LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg18099408 chr3:52552593 STAB1 -0.41 -7.03 -0.36 1.2e-11 Bipolar disorder; LUSC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg25566285 chr7:158114605 PTPRN2 0.35 6.53 0.34 2.52e-10 Calcium levels; LUSC cis rs17092148 0.945 rs6142237 chr20:33340993 C/T cg16810054 chr20:33298113 TP53INP2 -0.41 -6.47 -0.33 3.42e-10 Neuroticism; LUSC cis rs9549367 0.789 rs9577220 chr13:113908294 T/A cg18105134 chr13:113819100 PROZ -0.65 -9.59 -0.46 2.1e-19 Platelet distribution width; LUSC cis rs2074585 0.806 rs8033813 chr15:90999715 A/T cg04176472 chr15:90893244 GABARAPL3 0.35 6.02 0.31 4.53e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg14629032 chr9:94185528 NFIL3 0.38 6.08 0.32 3.3e-9 Schizophrenia; LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg11645453 chr3:52864694 ITIH4 0.34 7.78 0.39 8.92e-14 Bipolar disorder; LUSC trans rs2739330 0.796 rs5760106 chr22:24250645 A/C cg06437703 chr8:37914619 EIF4EBP1 0.57 8.87 0.44 4.61e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg25566285 chr7:158114605 PTPRN2 -0.33 -6.22 -0.32 1.5e-9 Calcium levels; LUSC trans rs4332037 0.950 rs7807014 chr7:1939021 T/C cg25206134 chr2:45395956 NA 0.56 6.42 0.33 4.61e-10 Bipolar disorder; LUSC trans rs7824557 0.564 rs2736293 chr8:11234613 T/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.61 -0.38 2.74e-13 Retinal vascular caliber; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg23034840 chr1:205782522 SLC41A1 0.62 8.8 0.43 7.43e-17 Menarche (age at onset); LUSC cis rs2832077 0.883 rs11702413 chr21:30188395 A/C cg08807101 chr21:30365312 RNF160 -0.53 -6.68 -0.34 9.85e-11 Cognitive test performance; LUSC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.18e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs751728 0.664 rs12190029 chr6:33749152 T/A cg25922239 chr6:33757077 LEMD2 0.43 6.48 0.33 3.22e-10 Crohn's disease; LUSC cis rs16854884 0.586 rs6782789 chr3:143746691 G/A cg06585982 chr3:143692056 C3orf58 0.52 8.29 0.41 2.86e-15 Economic and political preferences (feminism/equality); LUSC cis rs244731 0.919 rs12652509 chr5:176626441 A/G cg06060754 chr5:176797920 RGS14 -0.61 -8.6 -0.43 3.13e-16 Urate levels in lean individuals; LUSC cis rs9503598 0.636 rs7766753 chr6:3467708 A/C cg00476032 chr6:3446245 SLC22A23 0.3 5.88 0.31 9.78e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg18904891 chr8:8559673 CLDN23 0.6 8.08 0.4 1.2e-14 Obesity-related traits; LUSC cis rs308447 0.516 rs732676 chr4:123717476 T/C cg10495464 chr4:123653540 BBS12;LOC729338 0.84 11.44 0.53 8.46e-26 Perceived unattractiveness to mosquitoes; LUSC cis rs453301 0.686 rs11787026 chr8:8902371 A/T cg06636001 chr8:8085503 FLJ10661 0.45 6.78 0.35 5.53e-11 Joint mobility (Beighton score); LUSC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg09365446 chr1:150670422 GOLPH3L -0.41 -5.94 -0.31 7.25e-9 Tonsillectomy; LUSC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs977987 0.750 rs4888407 chr16:75432390 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.84 -0.35 3.73e-11 Dupuytren's disease; LUSC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg14004847 chr7:1930337 MAD1L1 -0.5 -7.61 -0.38 2.81e-13 Schizophrenia; LUSC cis rs8114671 0.562 rs6120746 chr20:33448496 A/G cg07148914 chr20:33460835 GGT7 0.56 8.42 0.42 1.14e-15 Height; LUSC cis rs4595586 0.545 rs11615700 chr12:39365104 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.17 0.37 4.71e-12 Morning vs. evening chronotype; LUSC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg13531842 chr10:38383804 ZNF37A -0.47 -7.35 -0.37 1.49e-12 Extrinsic epigenetic age acceleration; LUSC trans rs9329221 0.510 rs6995837 chr8:9975675 T/C cg15556689 chr8:8085844 FLJ10661 0.52 7.78 0.39 9.42e-14 Neuroticism; LUSC cis rs12579753 0.917 rs12822036 chr12:82183009 C/T cg21231944 chr12:82153410 PPFIA2 -0.38 -5.87 -0.31 1.03e-8 Resting heart rate; LUSC cis rs28647808 0.881 rs7040821 chr9:136263584 C/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs2439831 0.867 rs3101443 chr15:43912372 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC cis rs3816788 0.620 rs11783414 chr8:21773384 A/G cg17168535 chr8:21777572 XPO7 -0.66 -11.0 -0.52 3.19e-24 Lung cancer in ever smokers; LUSC cis rs7215564 0.908 rs4536520 chr17:78660239 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs1908814 0.516 rs58869268 chr8:11797095 G/C cg21775007 chr8:11205619 TDH 0.46 6.46 0.33 3.75e-10 Neuroticism; LUSC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg06713675 chr4:122721982 EXOSC9 -0.66 -11.68 -0.54 1.2e-26 Type 2 diabetes; LUSC cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg24397884 chr7:158709396 WDR60 0.62 9.56 0.46 2.71e-19 Height; LUSC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs6667605 0.527 rs12046118 chr1:2540343 A/C cg18932078 chr1:2524107 MMEL1 0.28 6.15 0.32 2.18e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7800944 0.715 rs12540011 chr7:72991704 G/A cg07452164 chr7:72993570 TBL2 0.47 6.7 0.34 8.62e-11 Coffee consumption (cups per day); LUSC cis rs2299587 0.560 rs11987695 chr8:17781085 A/G cg01800426 chr8:17659068 MTUS1 -0.48 -6.41 -0.33 4.82e-10 Economic and political preferences; LUSC cis rs765787 0.505 rs4439707 chr15:45524216 G/A cg24006582 chr15:45444508 DUOX1 0.66 9.5 0.46 4.32e-19 Uric acid levels; LUSC cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg24642439 chr20:33292090 TP53INP2 0.75 12.41 0.56 2.44e-29 Coronary artery disease; LUSC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg09796270 chr17:17721594 SREBF1 0.42 7.51 0.38 5.43e-13 Total body bone mineral density; LUSC cis rs7824557 0.592 rs920044 chr8:11224313 C/T cg21775007 chr8:11205619 TDH 0.78 12.75 0.57 1.35e-30 Retinal vascular caliber; LUSC cis rs2346177 0.875 rs1447565 chr2:46643682 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.56 -8.83 -0.44 5.91e-17 HDL cholesterol; LUSC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg05872129 chr22:39784769 NA -0.58 -10.59 -0.5 8.65e-23 Intelligence (multi-trait analysis); LUSC cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.47 0.75 6.13e-61 Cognitive ability; LUSC cis rs1559088 0.948 rs3760893 chr19:33597930 C/A cg03563238 chr19:33554763 RHPN2 -0.41 -6.56 -0.34 2.09e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg17845761 chr1:175162550 KIAA0040 0.31 5.98 0.31 5.7e-9 Alcohol dependence; LUSC cis rs3750965 1.000 rs7950657 chr11:68834831 G/A cg06818126 chr11:68850279 TPCN2 -0.44 -6.25 -0.32 1.25e-9 Hair color; LUSC cis rs9644630 0.672 rs4486225 chr8:19313404 A/G cg06562184 chr8:19319451 CSGALNACT1 0.48 8.01 0.4 1.96e-14 Oropharynx cancer; LUSC cis rs7568458 0.837 rs3731827 chr2:85806068 T/C cg02493740 chr2:85810744 VAMP5 -0.32 -5.78 -0.3 1.72e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs561341 0.825 rs2008368 chr17:30347397 T/C cg20587970 chr11:113659929 NA -1.35 -19.04 -0.72 3.02e-55 Hip circumference adjusted for BMI; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12787624 chr12:50677281 LIMA1 -0.41 -6.19 -0.32 1.78e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7618501 0.602 rs34831713 chr3:50118748 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.3 -0.45 1.92e-18 Intelligence (multi-trait analysis); LUSC cis rs12618769 0.652 rs72823801 chr2:99235055 A/G cg10123293 chr2:99228465 UNC50 0.46 7.54 0.38 4.42e-13 Bipolar disorder; LUSC cis rs926938 0.618 rs360617 chr1:115404099 G/A cg12756093 chr1:115239321 AMPD1 0.47 7.23 0.37 3.25e-12 Autism; LUSC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg07414643 chr4:187882934 NA 0.56 10.7 0.51 3.67e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.967 rs373527 chr6:145801861 C/T cg23711669 chr6:146136114 FBXO30 0.71 12.28 0.56 7.14e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs2731664 0.740 rs2731670 chr5:176848019 G/T cg23176889 chr5:176863531 GRK6 0.61 12.18 0.55 1.65e-28 Intelligence (multi-trait analysis); LUSC cis rs2760061 0.626 rs596675 chr1:228117892 G/A cg01973587 chr1:228161476 NA 0.45 8.09 0.4 1.15e-14 Diastolic blood pressure; LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg06873352 chr17:61820015 STRADA 0.71 12.72 0.57 1.68e-30 Prudent dietary pattern; LUSC trans rs1973993 0.903 rs2038646 chr1:96940371 C/G cg10631902 chr5:14652156 NA 0.53 8.82 0.43 6.25e-17 Weight; LUSC cis rs2346177 0.554 rs13002880 chr2:46708129 C/G cg02822958 chr2:46747628 ATP6V1E2 0.46 8.22 0.41 4.44e-15 HDL cholesterol; LUSC cis rs6733011 0.500 rs885115 chr2:99446445 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.46 -6.15 -0.32 2.18e-9 Bipolar disorder; LUSC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg00677455 chr12:58241039 CTDSP2 0.72 11.19 0.52 6.61e-25 Multiple sclerosis; LUSC cis rs9325144 0.624 rs10506126 chr12:39123244 G/A cg13010199 chr12:38710504 ALG10B -0.47 -7.23 -0.37 3.3e-12 Morning vs. evening chronotype; LUSC cis rs4680 0.737 rs2239393 chr22:19950428 A/G cg22546130 chr22:19950026 COMT -0.39 -8.42 -0.42 1.1e-15 Blood metabolite levels; LUSC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg24060327 chr5:131705240 SLC22A5 0.66 10.98 0.51 3.75e-24 Breast cancer; LUSC trans rs61931739 1.000 rs12304768 chr12:34000986 T/G cg26384229 chr12:38710491 ALG10B -0.52 -7.83 -0.39 6.63e-14 Morning vs. evening chronotype; LUSC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg23985595 chr17:80112537 CCDC57 -0.31 -6.11 -0.32 2.82e-9 Life satisfaction; LUSC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7424096 0.582 rs7600245 chr2:37220614 A/C cg14987922 chr2:37194071 STRN 0.61 8.25 0.41 3.78e-15 High light scatter reticulocyte percentage of red cells; LUSC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs12493885 0.769 rs61791540 chr3:153757041 G/A cg17054900 chr3:154042577 DHX36 -0.67 -7.06 -0.36 9.76e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC trans rs7829975 0.711 rs12682352 chr8:8646246 A/G cg27411982 chr8:10470053 RP1L1 0.41 6.63 0.34 1.39e-10 Mood instability; LUSC cis rs8141529 0.748 rs132529 chr22:29296652 A/G cg15103426 chr22:29168792 CCDC117 -0.44 -5.73 -0.3 2.24e-8 Lymphocyte counts; LUSC cis rs7937682 0.889 rs3017767 chr11:111508098 A/G cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs11039100 1.000 rs61875915 chr11:5828568 A/G cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2219968 0.740 rs7829841 chr8:78918716 G/T cg00738934 chr8:78996279 NA 0.34 5.99 0.31 5.54e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs62238980 0.614 rs4821013 chr22:32388224 A/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs1775715 0.678 rs7096139 chr10:32217404 A/C cg03015672 chr10:32216066 ARHGAP12 0.32 5.74 0.3 2.17e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs735396 0.770 rs1169300 chr12:121431225 G/A cg02403541 chr12:121454288 C12orf43 0.7 9.82 0.47 3.54e-20 N-glycan levels; LUSC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.63 0.5 6.1e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs6773957 1.000 rs3774261 chr3:186571559 C/T cg01963189 chr4:121613795 NA 0.33 6.14 0.32 2.3e-9 Adiponectin levels; LUSC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs1595825 0.891 rs73056859 chr2:198801720 A/G cg10547527 chr2:198650123 BOLL -0.5 -5.79 -0.3 1.64e-8 Ulcerative colitis; LUSC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg24531977 chr5:56204891 C5orf35 0.7 10.21 0.49 1.75e-21 Coronary artery disease; LUSC cis rs7267979 0.528 rs34485039 chr20:25583763 G/T cg03522245 chr20:25566470 NINL -0.4 -6.09 -0.32 3.11e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg01416388 chr22:39784598 NA -0.43 -6.67 -0.34 1.04e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs983392 0.678 rs4938933 chr11:60034429 C/T cg24026212 chr11:59952134 MS4A6A 0.37 6.43 0.33 4.29e-10 Alzheimer's disease (late onset); LUSC trans rs12524093 0.541 rs79673384 chr6:143040299 C/A cg22454011 chr18:13611439 C18orf1 0.68 5.96 0.31 6.53e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs8073060 0.586 rs7214742 chr17:33981969 C/A cg19694781 chr19:47549865 TMEM160 -1.15 -17.97 -0.7 5.57e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs3849570 1.000 rs3772882 chr3:81808602 C/A cg07356753 chr3:81810745 GBE1 -0.57 -9.01 -0.44 1.59e-17 Waist circumference;Body mass index; LUSC cis rs9287719 0.967 rs6432118 chr2:10749441 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg16434002 chr17:42200994 HDAC5 0.46 6.75 0.35 6.63e-11 Total body bone mineral density; LUSC cis rs9463078 0.605 rs17339124 chr6:44942577 C/G cg25276700 chr6:44698697 NA 0.28 5.91 0.31 8.4e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs2392780 0.514 rs653605 chr8:128338847 G/T cg10195415 chr17:73887371 TRIM65 0.41 6.64 0.34 1.3100000000000001e-10 Breast cancer (early onset); LUSC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.21e-12 Schizophrenia; LUSC cis rs12579753 1.000 rs12579753 chr12:82219376 C/T cg07988820 chr12:82153109 PPFIA2 -0.42 -5.85 -0.3 1.18e-8 Resting heart rate; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs936229 1.000 rs936229 chr15:75132319 A/G cg10253484 chr15:75165896 SCAMP2 -0.51 -6.68 -0.34 1.03e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC cis rs3768617 0.706 rs6678517 chr1:183002639 A/G ch.1.3577855R chr1:183094577 LAMC1 0.58 8.52 0.42 5.74e-16 Fuchs's corneal dystrophy; LUSC cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg14844989 chr11:31128820 NA -0.37 -5.85 -0.3 1.18e-8 Red blood cell count; LUSC cis rs11098499 0.820 rs2389885 chr4:120533931 C/T cg24375607 chr4:120327624 NA 0.75 11.04 0.52 2.35e-24 Corneal astigmatism; LUSC cis rs4363385 0.642 rs58124215 chr1:152916375 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -6.95 -0.36 1.95e-11 Inflammatory skin disease; LUSC cis rs10045504 0.502 rs57589709 chr5:38733853 C/T cg15396434 chr5:38725168 NA -0.52 -5.8 -0.3 1.5e-8 Night sleep phenotypes; LUSC trans rs17039065 1.000 rs56717804 chr4:109394241 G/A cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.24e-10 Gut microbiome composition (summer); LUSC cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg17173187 chr15:85201210 NMB 0.37 5.89 0.31 9.64e-9 Schizophrenia; LUSC cis rs765787 0.530 rs2433229 chr15:45515235 C/A cg25801113 chr15:45476975 SHF 0.35 7.32 0.37 1.82e-12 Uric acid levels; LUSC cis rs9359856 0.956 rs9362664 chr6:90307703 G/A cg13799429 chr6:90582589 CASP8AP2 0.55 6.41 0.33 5.1e-10 Bipolar disorder; LUSC cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg08917208 chr2:24149416 ATAD2B 0.55 6.26 0.32 1.17e-9 Lymphocyte counts; LUSC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg05084668 chr3:125655381 ALG1L -0.5 -7.12 -0.36 6.65e-12 Blood pressure (smoking interaction); LUSC cis rs34779708 0.931 rs7923172 chr10:35309367 G/A cg04310649 chr10:35416472 CREM -0.4 -6.07 -0.32 3.45e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9648716 0.515 rs79007238 chr7:140651724 C/T cg23214464 chr7:140373596 ADCK2 0.69 6.05 0.31 3.88e-9 Type 2 diabetes; LUSC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -14.03 -0.61 1.77e-35 Hemoglobin concentration; LUSC cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg23788917 chr6:8435910 SLC35B3 0.52 7.77 0.39 9.8e-14 Motion sickness; LUSC cis rs7923609 0.746 rs7070761 chr10:65317056 A/T cg01631684 chr10:65280961 REEP3 0.41 6.05 0.31 3.84e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs11098499 1.000 rs35643470 chr4:120184948 T/C cg24375607 chr4:120327624 NA 0.75 11.2 0.52 6.02e-25 Corneal astigmatism; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg07404485 chr7:94953653 PON1 0.3 5.8 0.3 1.54e-8 Paraoxonase activity; LUSC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.66 -0.39 2.1e-13 Intelligence (multi-trait analysis); LUSC cis rs6977660 0.714 rs6976854 chr7:19818311 A/G cg07541023 chr7:19748670 TWISTNB 0.6 6.51 0.34 2.7e-10 Thyroid stimulating hormone; LUSC cis rs7954584 0.813 rs11043288 chr12:122451187 C/T cg13699009 chr12:122356056 WDR66 -0.4 -6.13 -0.32 2.46e-9 Mean corpuscular volume; LUSC cis rs62408225 1.000 rs62408233 chr6:90976609 G/A cg06866423 chr6:90926672 BACH2 0.42 5.96 0.31 6.26e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg18252515 chr7:66147081 NA -0.83 -9.37 -0.46 1.12e-18 Diabetic kidney disease; LUSC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg11764359 chr7:65958608 NA -0.7 -10.7 -0.51 3.47e-23 Aortic root size; LUSC cis rs4865169 0.934 rs12650737 chr4:57892475 G/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.37 -5.67 -0.3 3.1e-8 Breast cancer; LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.76 -9.76 -0.47 5.72e-20 Gut microbiome composition (summer); LUSC cis rs807669 0.548 rs5746685 chr22:19192596 C/G cg02655711 chr22:19163373 SLC25A1 -0.6 -10.67 -0.5 4.73e-23 Metabolite levels; LUSC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg02018176 chr4:1364513 KIAA1530 0.5 8.84 0.44 5.6e-17 Obesity-related traits; LUSC cis rs66887589 0.616 rs10032299 chr4:120206419 C/T cg09307838 chr4:120376055 NA 0.5 7.48 0.38 6.54e-13 Diastolic blood pressure; LUSC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg06634786 chr22:41940651 POLR3H -0.57 -6.44 -0.33 4.11e-10 Vitiligo; LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.44 6.0 0.31 5e-9 Renal function-related traits (BUN); LUSC trans rs4711689 1.000 rs4711689 chr6:41692812 C/T cg14182588 chr15:74754012 UBL7 -0.45 -6.13 -0.32 2.51e-9 Colorectal cancer; LUSC trans rs931812 0.895 rs13251731 chr8:101902528 C/G cg20993868 chr7:22813445 NA 0.63 11.34 0.53 1.98e-25 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs4631830 0.683 rs10763193 chr10:51504938 G/A cg20129853 chr10:51489980 NA 0.36 7.45 0.38 7.84e-13 Prostate-specific antigen levels; LUSC cis rs12824058 1.000 rs12824058 chr12:130804334 A/G cg27633287 chr12:130766243 NA 0.32 5.89 0.31 9.23e-9 Menopause (age at onset); LUSC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg22535103 chr8:58192502 C8orf71 -0.75 -7.79 -0.39 8.27e-14 Developmental language disorder (linguistic errors); LUSC trans rs984440 0.542 rs4909732 chr8:139079704 T/A cg03334052 chr1:168888044 NA 0.41 6.45 0.33 3.95e-10 Obesity-related traits; LUSC cis rs208520 0.874 rs208469 chr6:66915891 T/C cg07460842 chr6:66804631 NA -1.01 -14.28 -0.62 1.98e-36 Exhaled nitric oxide output; LUSC cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg07424592 chr7:64974309 NA 0.64 5.87 0.31 1.07e-8 Diabetic kidney disease; LUSC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.27e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.6 -0.57 4.72e-30 Chronic sinus infection; LUSC cis rs4253772 0.872 rs45552534 chr22:46638171 G/A cg18190219 chr22:46762943 CELSR1 -0.48 -5.81 -0.3 1.45e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs2262909 0.889 rs61268244 chr19:22310130 C/T cg11619707 chr19:22235551 ZNF257 0.39 5.9 0.31 8.73e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.42 -0.33 4.68e-10 Breast cancer; LUSC cis rs7189233 1.000 rs62048520 chr16:53491095 C/A cg09728985 chr16:53543985 NA -0.33 -5.92 -0.31 8.05e-9 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg13395646 chr4:1353034 KIAA1530 -0.57 -8.84 -0.44 5.8e-17 Obesity-related traits; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg11060661 chr22:24314208 DDT;DDTL 0.48 7.85 0.39 5.73e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg06221963 chr1:154839813 KCNN3 -0.63 -14.77 -0.63 2.51e-38 Prostate cancer; LUSC cis rs7264396 0.887 rs224370 chr20:34073379 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.34 -0.33 7.56e-10 Total cholesterol levels; LUSC trans rs3942852 0.568 rs2904315 chr11:48109948 C/T cg15704280 chr7:45808275 SEPT13 0.63 8.45 0.42 9.4e-16 Acute lymphoblastic leukemia (childhood); LUSC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg12524338 chr4:183729343 NA 0.68 8.62 0.43 2.81e-16 Pediatric autoimmune diseases; LUSC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.46 6.75 0.35 6.52e-11 Eosinophil percentage of white cells; LUSC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -11.85 -0.54 2.77e-27 Hemoglobin concentration; LUSC cis rs4786125 0.706 rs8062094 chr16:6902585 A/G cg03623568 chr16:6915990 A2BP1 -0.45 -7.83 -0.39 6.75e-14 Heart rate variability traits (SDNN); LUSC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg03806693 chr22:41940476 POLR3H -1.05 -15.17 -0.64 6.42e-40 Vitiligo; LUSC cis rs7772486 0.875 rs2814866 chr6:146339414 C/A cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 9.18e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg06552810 chr11:31128660 NA -0.41 -7.36 -0.37 1.44e-12 Red blood cell count; LUSC trans rs11098499 0.645 rs72676059 chr4:120290828 C/G cg25214090 chr10:38739885 LOC399744 0.49 7.53 0.38 4.82e-13 Corneal astigmatism; LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg00684032 chr4:1343700 KIAA1530 0.33 5.77 0.3 1.85e-8 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26251069 chr18:657649 C18orf56;TYMS -0.44 -6.32 -0.33 8.35e-10 Electrocardiographic conduction measures; LUSC cis rs9739070 1 rs9739070 chr12:123771032 A/G cg00376283 chr12:123451042 ABCB9 0.68 7.82 0.39 7.13e-14 Allergy; LUSC cis rs7177699 0.557 rs4389112 chr15:79122099 G/A cg15571903 chr15:79123663 NA -0.32 -5.79 -0.3 1.64e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs76878669 0.561 rs7125752 chr11:66162419 C/T cg18002602 chr11:66138449 SLC29A2 -0.47 -8.26 -0.41 3.54e-15 Educational attainment (years of education); LUSC trans rs62238980 0.614 rs4820066 chr22:32409269 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.01 0.48 8.39e-21 Electroencephalogram traits; LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg06634786 chr22:41940651 POLR3H 0.51 6.15 0.32 2.18e-9 Vitiligo; LUSC cis rs7267979 0.873 rs6132822 chr20:25228695 C/T cg08601574 chr20:25228251 PYGB 0.55 8.83 0.43 6.23e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9457247 1.000 rs393558 chr6:167397750 A/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.74 -0.35 6.85e-11 Crohn's disease; LUSC cis rs7795096 0.743 rs9648726 chr7:151537433 C/T cg17008978 chr7:151542804 PRKAG2 0.34 6.53 0.34 2.4e-10 Bipolar disorder (age of onset and psychotic symptoms); LUSC cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg22906224 chr7:99728672 NA 0.46 6.4 0.33 5.29e-10 Coronary artery disease; LUSC cis rs7903847 0.642 rs10882923 chr10:99159018 G/A cg08345082 chr10:99160200 RRP12 -0.35 -7.11 -0.36 7.29e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs1448094 0.836 rs7313442 chr12:86405642 C/T cg00310523 chr12:86230176 RASSF9 0.37 6.67 0.34 1.08e-10 Major depressive disorder; LUSC cis rs1728785 1.000 rs1645976 chr16:68563509 T/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs2262909 0.924 rs4290587 chr19:22164646 A/G cg11619707 chr19:22235551 ZNF257 -0.39 -5.73 -0.3 2.28e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg06552810 chr11:31128660 NA 0.42 7.32 0.37 1.89e-12 Red blood cell count; LUSC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg10018233 chr7:150070692 REPIN1 0.34 5.99 0.31 5.44e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs1325195 0.920 rs2493124 chr1:179099021 T/C cg11624085 chr17:8464688 MYH10 0.44 7.36 0.37 1.45e-12 IgE grass sensitization; LUSC cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.18 27.54 0.83 6.15e-88 Chronic sinus infection; LUSC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.09 0.45 8.68e-18 Total body bone mineral density; LUSC trans rs656319 0.625 rs34427895 chr8:9875221 G/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.2 -0.37 3.94e-12 Myopia (pathological); LUSC trans rs7647973 0.626 rs1996664 chr3:49878395 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.56 0.38 3.82e-13 Menarche (age at onset); LUSC cis rs6977660 0.660 rs10224938 chr7:19816227 A/G cg07541023 chr7:19748670 TWISTNB 0.65 7.0 0.36 1.43e-11 Thyroid stimulating hormone; LUSC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg04414720 chr1:150670196 GOLPH3L 0.55 9.02 0.44 1.56e-17 Tonsillectomy; LUSC cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg25019033 chr10:957182 NA -0.43 -5.7 -0.3 2.61e-8 Eosinophil percentage of granulocytes; LUSC cis rs2070433 0.756 rs9637220 chr21:47887436 T/C cg12379764 chr21:47803548 PCNT 0.7 9.35 0.46 1.27e-18 Lymphocyte counts; LUSC cis rs7851660 0.809 rs7034249 chr9:100653821 C/T cg13688889 chr9:100608707 NA -0.53 -8.06 -0.4 1.36e-14 Strep throat; LUSC cis rs6901250 0.655 rs1117046 chr6:117136978 G/C cg12892004 chr6:117198278 RFX6 0.4 7.61 0.38 2.75e-13 C-reactive protein levels; LUSC cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg06784218 chr1:46089804 CCDC17 0.48 9.37 0.46 1.11e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2078087 0.568 rs609648 chr1:183234329 C/T cg13843938 chr1:183241246 NMNAT2 -0.43 -6.99 -0.36 1.47e-11 Obesity-related traits; LUSC cis rs4746818 0.901 rs10740317 chr10:70937566 G/A cg11621586 chr10:70884670 VPS26A 1.13 10.72 0.51 3.08e-23 Left atrial antero-posterior diameter; LUSC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg08470875 chr2:26401718 FAM59B -0.64 -8.37 -0.42 1.55e-15 Gut microbiome composition (summer); LUSC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg20744362 chr22:50050164 C22orf34 0.38 7.85 0.39 5.69e-14 Monocyte count;Monocyte percentage of white cells; LUSC trans rs7726839 0.574 rs72705017 chr5:623733 G/A cg11887960 chr12:57824829 NA 0.54 6.67 0.34 1.07e-10 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09700855 chr17:78194207 SLC26A11;SGSH -0.41 -6.52 -0.34 2.64e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs559928 0.606 rs55942618 chr11:63936005 C/T cg24687543 chr11:63912206 MACROD1 0.47 5.82 0.3 1.4e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2439831 1.000 rs2467736 chr15:43784917 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs11098499 0.908 rs71614449 chr4:120387055 C/T cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.59e-25 Corneal astigmatism; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg05660315 chr16:30543920 ZNF747 -0.4 -6.07 -0.32 3.5e-9 N-glycan levels; LUSC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg03060546 chr3:49711283 APEH 0.71 12.09 0.55 3.6e-28 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg11764359 chr7:65958608 NA -0.78 -12.93 -0.58 2.79e-31 Aortic root size; LUSC cis rs2120019 1.000 rs2415255 chr15:75332412 A/G cg17294928 chr15:75287854 SCAMP5 -0.92 -13.07 -0.58 8.12e-32 Blood trace element (Zn levels); LUSC cis rs6736093 0.966 rs4848899 chr2:112710111 G/A cg12686935 chr2:112915763 FBLN7 -0.36 -5.81 -0.3 1.45e-8 Coronary artery disease; LUSC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg11752832 chr7:134001865 SLC35B4 0.56 8.78 0.43 8.84e-17 Mean platelet volume; LUSC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg02034447 chr16:89574710 SPG7 0.43 6.44 0.33 4.16e-10 Multiple myeloma (IgH translocation); LUSC cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg19628046 chr18:33552617 C18orf21 0.51 6.13 0.32 2.48e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg14552801 chr7:65878734 NA 0.47 6.69 0.34 9.59e-11 Aortic root size; LUSC cis rs12478296 0.748 rs10185596 chr2:243001029 C/A cg06360820 chr2:242988706 NA -0.75 -9.11 -0.45 7.66e-18 Obesity-related traits; LUSC trans rs7824557 0.767 rs2164273 chr8:11168499 A/G cg06636001 chr8:8085503 FLJ10661 0.53 8.0 0.4 2.02e-14 Retinal vascular caliber; LUSC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC cis rs354225 0.544 rs28581481 chr2:54812372 T/G cg01766943 chr2:54829624 SPTBN1 0.48 7.95 0.4 2.81e-14 Schizophrenia; LUSC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg07741184 chr6:167504864 NA -0.35 -6.39 -0.33 5.46e-10 Crohn's disease; LUSC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg20891283 chr12:69753455 YEATS4 0.63 9.62 0.47 1.67e-19 Blood protein levels; LUSC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.19 -0.37 4.24e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg05861140 chr6:150128134 PCMT1 0.39 6.09 0.32 3.09e-9 Lung cancer; LUSC trans rs17189298 0.904 rs12998633 chr2:119841720 A/C cg00109356 chr13:26625307 SHISA2 0.31 5.98 0.31 5.88e-9 Cerebrospinal T-tau levels; LUSC cis rs9300255 0.664 rs28636834 chr12:123871070 A/C cg00376283 chr12:123451042 ABCB9 -0.66 -7.58 -0.38 3.47e-13 Neutrophil percentage of white cells; LUSC cis rs4363385 0.667 rs73014331 chr1:152964533 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.51 -0.38 5.59e-13 Inflammatory skin disease; LUSC cis rs4654899 0.604 rs12031023 chr1:21148839 A/G cg01072550 chr1:21505969 NA 0.47 6.99 0.36 1.47e-11 Superior frontal gyrus grey matter volume; LUSC cis rs1949733 1.000 rs3103071 chr4:8508579 C/G cg13073564 chr4:8508604 NA 0.52 9.57 0.46 2.44e-19 Response to antineoplastic agents; LUSC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs13089785 0.965 rs67028142 chr3:123635213 A/G cg01860459 chr3:123419554 MYLK 0.35 5.94 0.31 7.31e-9 Intelligence (multi-trait analysis); LUSC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg06212747 chr3:49208901 KLHDC8B 0.46 6.31 0.33 8.62e-10 Parkinson's disease; LUSC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg20908204 chr19:46285434 DMPK 0.41 8.19 0.41 5.76e-15 Coronary artery disease; LUSC cis rs6430585 0.583 rs4988163 chr2:136628121 G/T cg07169764 chr2:136633963 MCM6 1.17 18.26 0.71 3.72e-52 Corneal structure; LUSC cis rs1580019 0.844 rs1584615 chr7:32503258 G/C cg06627557 chr7:32535165 LSM5;AVL9 0.84 12.36 0.56 3.88e-29 Cognitive ability; LUSC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -5.83 -0.3 1.3e-8 Lung cancer; LUSC cis rs4474465 0.688 rs4275650 chr11:78284822 T/A cg27205649 chr11:78285834 NARS2 0.56 6.89 0.35 2.79e-11 Alzheimer's disease (survival time); LUSC cis rs983392 0.868 rs7933202 chr11:59936926 A/C cg24026212 chr11:59952134 MS4A6A -0.34 -5.65 -0.3 3.36e-8 Alzheimer's disease (late onset); LUSC cis rs10791097 0.694 rs2155751 chr11:130755240 G/A cg12179176 chr11:130786555 SNX19 0.86 15.1 0.64 1.19e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.67 -0.39 1.94e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg09655341 chr17:79618100 PDE6G -0.29 -6.59 -0.34 1.67e-10 Eye color traits; LUSC cis rs2742417 1.000 rs2742431 chr3:45737121 C/G cg09608765 chr3:45636137 LIMD1 0.35 6.95 0.36 1.95e-11 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04665974 chr16:30103391 TBX6 0.73 6.13 0.32 2.51e-9 Cognitive performance; LUSC cis rs2985684 0.740 rs2883438 chr14:50044392 T/C cg04989706 chr14:50066350 PPIL5 -0.46 -5.97 -0.31 5.99e-9 Carotid intima media thickness; LUSC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg15704280 chr7:45808275 SEPT13 -0.84 -14.24 -0.61 2.68e-36 Height; LUSC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.14 17.29 0.69 2.79e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs9487051 0.735 rs419106 chr6:109520067 C/G cg01475377 chr6:109611718 NA -0.36 -6.23 -0.32 1.37e-9 Reticulocyte fraction of red cells; LUSC cis rs9858542 0.537 rs2304442 chr3:49322027 A/T cg00383909 chr3:49044727 WDR6 -0.62 -7.61 -0.38 2.73e-13 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6500395 1.000 rs9936467 chr16:48677983 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.86e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7267979 1.000 rs6138575 chr20:25438952 G/A cg03522245 chr20:25566470 NINL 0.35 5.7 0.3 2.66e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg05234568 chr11:5960015 NA -0.6 -8.66 -0.43 2.01e-16 DNA methylation (variation); LUSC cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg25208724 chr1:156163844 SLC25A44 1.05 17.93 0.7 8.17e-51 Testicular germ cell tumor; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26161045 chr2:55277080 RTN4 -0.54 -6.58 -0.34 1.86e-10 Bipolar disorder and schizophrenia; LUSC cis rs742132 0.527 rs17252870 chr6:25494666 A/C cg03517284 chr6:25882590 NA -0.44 -6.18 -0.32 1.86e-9 Uric acid levels; LUSC cis rs6696846 0.740 rs11240369 chr1:205115099 G/A cg03948781 chr1:205179583 DSTYK 0.32 6.17 0.32 1.95e-9 Red blood cell count; LUSC cis rs111547017 1 rs111547017 chr6:43341689 A/G cg26312998 chr6:43337775 ZNF318 0.57 6.62 0.34 1.4e-10 Schizophrenia; LUSC cis rs7918232 0.627 rs6482588 chr10:27308307 G/C cg14442939 chr10:27389572 ANKRD26 0.53 6.07 0.32 3.4e-9 Breast cancer; LUSC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.41 -5.97 -0.31 6.02e-9 Schizophrenia; LUSC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg00310523 chr12:86230176 RASSF9 -0.44 -8.28 -0.41 3.05e-15 Major depressive disorder; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.54 -8.21 -0.41 4.94e-15 Gut microbiome composition (summer); LUSC cis rs9902453 0.765 rs6505143 chr17:28150585 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.73 11.72 0.54 8.14e-27 Coffee consumption (cups per day); LUSC cis rs12928939 0.723 rs71403864 chr16:71695030 C/T cg08717414 chr16:71523259 ZNF19 -0.41 -5.76 -0.3 1.87e-8 Post bronchodilator FEV1; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg14893161 chr1:205819251 PM20D1 0.54 8.94 0.44 2.67e-17 Menarche (age at onset); LUSC cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.45 -6.73 -0.35 7.22e-11 Rheumatoid arthritis; LUSC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.91 0.31 8.46e-9 Tonsillectomy; LUSC cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg00530320 chr1:46809349 NSUN4 -0.58 -9.03 -0.44 1.37e-17 Menopause (age at onset); LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg22963979 chr7:1858916 MAD1L1 -0.73 -12.18 -0.55 1.69e-28 Bipolar disorder and schizophrenia; LUSC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg21918786 chr6:109611834 NA -0.38 -6.47 -0.33 3.45e-10 Reticulocyte fraction of red cells; LUSC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg21724239 chr8:58056113 NA 0.8 9.0 0.44 1.69e-17 Developmental language disorder (linguistic errors); LUSC cis rs4919694 1.000 rs11191473 chr10:104710710 C/G cg04362960 chr10:104952993 NT5C2 1.15 13.83 0.6 1.01e-34 Arsenic metabolism; LUSC cis rs55986470 0.646 rs79795396 chr2:239419181 T/C cg18131467 chr2:239335373 ASB1 -0.78 -6.16 -0.32 2.14e-9 Chronotype; LUSC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg06481639 chr22:41940642 POLR3H -0.5 -5.78 -0.3 1.73e-8 Vitiligo; LUSC cis rs72781680 0.898 rs72780125 chr2:24000145 T/C cg20701182 chr2:24300061 SF3B14 0.71 7.14 0.36 5.77e-12 Lymphocyte counts; LUSC cis rs11779988 0.545 rs208764 chr8:17806270 G/A cg01800426 chr8:17659068 MTUS1 -0.47 -5.91 -0.31 8.27e-9 Breast cancer; LUSC cis rs61931739 0.635 rs3937819 chr12:33942715 A/G cg06521331 chr12:34319734 NA -0.41 -6.71 -0.34 8.31e-11 Morning vs. evening chronotype; LUSC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg08847533 chr14:75593920 NEK9 -0.81 -13.81 -0.6 1.21e-34 Height; LUSC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg14829360 chr17:73884958 NA -0.35 -5.89 -0.31 9.41e-9 White matter hyperintensity burden; LUSC cis rs4888262 0.526 rs4404098 chr16:74570050 G/A cg01733217 chr16:74700730 RFWD3 0.7 11.22 0.52 5.39e-25 Testicular germ cell tumor; LUSC cis rs9527 0.590 rs3781281 chr10:104852648 A/G cg05855489 chr10:104503620 C10orf26 -0.56 -8.75 -0.43 1.09e-16 Arsenic metabolism; LUSC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg08847533 chr14:75593920 NEK9 0.83 14.38 0.62 7.83e-37 Height; LUSC cis rs11792861 0.926 rs7046725 chr9:111882729 T/G cg05043794 chr9:111880884 C9orf5 -0.36 -7.94 -0.4 3.01e-14 Menarche (age at onset); LUSC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg08645402 chr16:4508243 NA 0.49 7.83 0.39 6.43e-14 Schizophrenia; LUSC cis rs9467773 0.844 rs2393669 chr6:26503873 C/T cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.97e-18 Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs138709 chr22:39139216 C/G cg06022373 chr22:39101656 GTPBP1 0.75 11.75 0.54 6.67e-27 Menopause (age at onset); LUSC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg06022373 chr22:39101656 GTPBP1 0.77 12.39 0.56 2.9e-29 Menopause (age at onset); LUSC cis rs4845459 0.967 rs4085613 chr1:152550018 T/G cg08895932 chr1:152778580 LCE1C -0.36 -6.1 -0.32 2.91e-9 Psoriasis; LUSC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg06112835 chr11:68658793 MRPL21 0.51 7.82 0.39 7.13e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12286929 0.839 rs12803174 chr11:115023159 T/C cg04055981 chr11:115044050 NA 0.33 5.77 0.3 1.83e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs354225 0.584 rs9677089 chr2:54794927 A/C cg01766943 chr2:54829624 SPTBN1 0.44 7.08 0.36 8.74e-12 Schizophrenia; LUSC cis rs6541297 0.938 rs1555289 chr1:230292499 C/T cg05784532 chr1:230284198 GALNT2 -0.64 -8.77 -0.43 9.56e-17 Coronary artery disease; LUSC trans rs4957048 0.891 rs11960196 chr5:568857 C/A cg11887960 chr12:57824829 NA 0.47 6.38 0.33 5.9e-10 Ulcerative colitis; LUSC trans rs853679 0.567 rs3799499 chr6:28354250 G/T cg01620082 chr3:125678407 NA -0.44 -6.46 -0.33 3.68e-10 Depression; LUSC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg16386425 chr10:429943 DIP2C -0.44 -7.03 -0.36 1.14e-11 Psychosis in Alzheimer's disease; LUSC trans rs3749237 0.964 rs2234385 chr3:49846041 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.47 6.6 0.34 1.57e-10 Resting heart rate; LUSC cis rs1018836 0.739 rs4734247 chr8:91569144 A/G cg16814680 chr8:91681699 NA -0.69 -11.0 -0.52 3.12e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg12963246 chr6:28129442 ZNF389 0.49 7.19 0.37 4.21e-12 Parkinson's disease; LUSC trans rs61931739 0.817 rs1705754 chr12:34145569 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.72 0.35 7.86e-11 Morning vs. evening chronotype; LUSC cis rs965513 1.000 rs10759927 chr9:100542176 A/G cg13688889 chr9:100608707 NA -0.57 -8.52 -0.42 5.73e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs6691722 0.506 rs12030365 chr1:24739220 T/A cg18323236 chr1:24743029 NIPAL3 0.39 6.66 0.34 1.1e-10 Response to interferon beta in multiple sclerosis; LUSC trans rs7819412 0.668 rs920047 chr8:11087475 C/T cg15556689 chr8:8085844 FLJ10661 -0.44 -6.7 -0.34 8.85e-11 Triglycerides; LUSC cis rs11958404 0.860 rs72818116 chr5:157440616 G/T cg05962755 chr5:157440814 NA 0.53 6.3 0.33 9.34e-10 IgG glycosylation; LUSC cis rs10892173 0.566 rs111578166 chr11:117666714 G/T cg21640587 chr11:117668038 DSCAML1 0.7 10.53 0.5 1.42e-22 Myopia; LUSC cis rs9788682 0.747 rs2656072 chr15:78744292 A/G cg18825076 chr15:78729989 IREB2 -0.45 -6.24 -0.32 1.3e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg05623727 chr3:50126028 RBM5 0.34 6.52 0.34 2.64e-10 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg23711669 chr6:146136114 FBXO30 -0.89 -17.19 -0.69 7.03e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg14004847 chr7:1930337 MAD1L1 -0.5 -7.33 -0.37 1.74e-12 Bipolar disorder and schizophrenia; LUSC cis rs17270561 0.887 rs12201170 chr6:25866247 A/G cg17691542 chr6:26056736 HIST1H1C 0.78 9.66 0.47 1.24e-19 Iron status biomarkers; LUSC cis rs1018836 0.632 rs6995399 chr8:91481629 T/C cg16814680 chr8:91681699 NA -0.64 -9.65 -0.47 1.38e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7582720 1.000 rs72932554 chr2:203845828 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs877282 0.842 rs35872126 chr10:764545 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg00990874 chr7:1149470 C7orf50 -0.5 -6.32 -0.33 8.61e-10 Bronchopulmonary dysplasia; LUSC cis rs6977660 0.660 rs61670426 chr7:19790460 A/G cg05791153 chr7:19748676 TWISTNB 0.78 8.3 0.41 2.53e-15 Thyroid stimulating hormone; LUSC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg14019146 chr3:50243930 SLC38A3 -0.36 -8.25 -0.41 3.68e-15 Body mass index; LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg16325326 chr1:53192061 ZYG11B 0.74 13.07 0.58 7.92e-32 Monocyte count; LUSC cis rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05901451 chr6:126070800 HEY2 -0.79 -14.15 -0.61 6.28e-36 Brugada syndrome; LUSC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg12560992 chr17:57184187 TRIM37 0.9 17.84 0.7 1.78e-50 Intelligence (multi-trait analysis); LUSC cis rs9837602 0.882 rs9875664 chr3:99729130 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 6.14 0.32 2.35e-9 Breast cancer; LUSC trans rs1941687 0.505 rs12605642 chr18:31313965 G/T cg27147174 chr7:100797783 AP1S1 -0.56 -8.85 -0.44 5.33e-17 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs11650494 0.908 rs78208413 chr17:47398282 G/A cg08112188 chr17:47440006 ZNF652 1.26 10.98 0.52 3.67e-24 Prostate cancer; LUSC trans rs3942852 0.568 rs4412719 chr11:48101660 T/A cg03929089 chr4:120376271 NA -0.58 -7.52 -0.38 5.07e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs6750795 0.569 rs1797387 chr2:232414692 A/G cg19187155 chr2:232395269 NMUR1 0.8 13.86 0.6 7.91e-35 Height; LUSC cis rs1577917 0.920 rs1337842 chr6:86675097 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -6.18 -0.32 1.87e-9 Response to antipsychotic treatment; LUSC cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg13010199 chr12:38710504 ALG10B -0.61 -9.53 -0.46 3.37e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg18225595 chr11:63971243 STIP1 0.5 6.2 0.32 1.63e-9 Mean platelet volume; LUSC cis rs9653442 0.564 rs7565895 chr2:100774773 G/A cg22139774 chr2:100720529 AFF3 -0.42 -7.23 -0.37 3.33e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg02018176 chr4:1364513 KIAA1530 0.53 9.24 0.45 2.99e-18 Obesity-related traits; LUSC cis rs2439831 1.000 rs2444032 chr15:43755346 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.86 9.0 0.44 1.76e-17 Lung cancer in ever smokers; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg03790207 chr6:42947109 PEX6 -0.45 -6.87 -0.35 3.1e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08867150 chr8:28259493 NA 0.81 6.67 0.34 1.03e-10 Cognitive performance; LUSC cis rs11779988 0.545 rs208058 chr8:17820433 G/A cg01800426 chr8:17659068 MTUS1 -0.48 -6.04 -0.31 4.03e-9 Breast cancer; LUSC cis rs72717009 0.825 rs7529225 chr1:161479352 G/A cg23840854 chr1:161414152 NA -0.91 -11.11 -0.52 1.34e-24 Rheumatoid arthritis; LUSC cis rs4595586 0.545 rs7136002 chr12:39369168 G/A cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg04539111 chr16:67997858 SLC12A4 -0.46 -6.25 -0.32 1.23e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs75804782 0.691 rs55886641 chr2:239319185 T/C cg18131467 chr2:239335373 ASB1 -0.74 -6.64 -0.34 1.28e-10 Morning vs. evening chronotype;Chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07970400 chr15:40650285 DISP2 -0.51 -6.7 -0.34 8.64e-11 Bipolar disorder and schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01591470 chr14:39736043 CTAGE5 -0.51 -6.54 -0.34 2.32e-10 Bipolar disorder and schizophrenia; LUSC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg14895029 chr7:2775587 GNA12 -0.37 -5.88 -0.31 9.96e-9 Height; LUSC cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg24642439 chr20:33292090 TP53INP2 -0.51 -7.63 -0.39 2.49e-13 Glomerular filtration rate (creatinine); LUSC cis rs7072216 0.763 rs733346 chr10:100164325 A/C cg26618903 chr10:100175079 PYROXD2 -0.47 -8.89 -0.44 3.82e-17 Metabolite levels; LUSC cis rs3741151 0.686 rs7114376 chr11:73227361 T/C cg17517138 chr11:73019481 ARHGEF17 0.8 7.43 0.38 9.37e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs71435601 0.628 rs574461 chr2:21400013 A/G cg20757404 chr19:378427 NA 0.37 5.96 0.31 6.28e-9 Cholesterol, total; LUSC cis rs760794 0.729 rs6921786 chr6:19794016 C/T cg02404759 chr6:19790362 NA 0.38 6.15 0.32 2.25e-9 Endometriosis; LUSC cis rs9457247 0.534 rs4710154 chr6:167394634 A/T cg23791538 chr6:167370224 RNASET2 0.5 8.44 0.42 1e-15 Crohn's disease; LUSC cis rs3789045 0.560 rs1002779 chr1:204405098 T/A cg17419461 chr1:204415978 PIK3C2B -0.5 -5.67 -0.3 3.1e-8 Educational attainment (college completion); LUSC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg19729930 chr2:74357872 NA 0.92 18.27 0.71 3.46e-52 Gestational age at birth (maternal effect); LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg07703079 chr11:430292 ANO9 0.69 6.94 0.36 2e-11 Body mass index; LUSC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg18240062 chr17:79603768 NPLOC4 -0.69 -12.86 -0.58 4.98e-31 Eye color traits; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10641809 chr6:34664703 C6orf106 0.4 6.21 0.32 1.58e-9 Asthma; LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg02018176 chr4:1364513 KIAA1530 0.52 8.86 0.44 5e-17 Obesity-related traits; LUSC cis rs6964587 0.692 rs418 chr7:91583334 C/T cg17063962 chr7:91808500 NA -0.57 -9.51 -0.46 3.99e-19 Breast cancer; LUSC cis rs5758511 0.680 rs5758682 chr22:42645202 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.89 -0.31 9.19e-9 Birth weight; LUSC cis rs10463316 0.894 rs4099169 chr5:150766526 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.32 -0.37 1.9e-12 Metabolite levels (Pyroglutamine); LUSC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg04518342 chr5:131593106 PDLIM4 0.39 7.19 0.37 4.21e-12 Breast cancer; LUSC trans rs7980799 0.649 rs2084391 chr12:33655419 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.01 -0.31 4.83e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs8017423 0.967 rs11159958 chr14:90716051 T/C cg14092571 chr14:90743983 NA -0.36 -5.9 -0.31 8.86e-9 Mortality in heart failure; LUSC cis rs7119 0.717 rs12916642 chr15:77818426 G/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.61 -0.34 1.53e-10 Type 2 diabetes; LUSC cis rs11098499 0.754 rs12513083 chr4:120249612 A/T cg09307838 chr4:120376055 NA 0.7 10.6 0.5 8.3e-23 Corneal astigmatism; LUSC cis rs7618501 1.000 rs34614773 chr3:49753003 T/G cg24110177 chr3:50126178 RBM5 0.4 6.46 0.33 3.73e-10 Intelligence (multi-trait analysis); LUSC cis rs62432291 0.764 rs436743 chr6:159655102 A/G cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg03676636 chr4:99064102 C4orf37 -0.36 -7.93 -0.4 3.26e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg24110177 chr3:50126178 RBM5 0.61 10.55 0.5 1.22e-22 Body mass index; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg15025769 chr15:72410003 MYO9A;SENP8 0.45 5.96 0.31 6.33e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs3126085 0.935 rs10749669 chr1:152177289 A/C cg26876637 chr1:152193138 HRNR -0.46 -6.7 -0.34 8.68e-11 Atopic dermatitis; LUSC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg23985595 chr17:80112537 CCDC57 -0.34 -6.51 -0.34 2.8e-10 Life satisfaction; LUSC cis rs4443100 0.670 rs9608071 chr22:23408118 G/T cg21100191 chr22:23484243 RTDR1 0.52 6.49 0.33 3.02e-10 Serum parathyroid hormone levels; LUSC cis rs2798269 1.000 rs11618032 chr13:22134891 T/C cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.13 -0.32 2.42e-9 PR segment; LUSC cis rs240764 0.817 rs239204 chr6:101135580 T/C cg09795085 chr6:101329169 ASCC3 0.42 6.17 0.32 2.01e-9 Neuroticism; LUSC cis rs4654899 0.931 rs10799679 chr1:21341776 A/G cg01072550 chr1:21505969 NA -0.53 -8.1 -0.41 1.02e-14 Superior frontal gyrus grey matter volume; LUSC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg17143192 chr8:8559678 CLDN23 0.59 8.53 0.42 5.04e-16 Obesity-related traits; LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg13798780 chr7:105162888 PUS7 0.56 6.12 0.32 2.55e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4845570 0.764 rs12122917 chr1:151716712 C/A cg07092448 chr1:151763213 TDRKH -1.05 -10.9 -0.51 6.96e-24 Coronary artery disease; LUSC cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg12698349 chr2:225449008 CUL3 0.67 8.58 0.43 3.55e-16 IgE levels in asthmatics (D.p. specific); LUSC cis rs8114671 0.967 rs34515766 chr20:33785221 C/G cg24642439 chr20:33292090 TP53INP2 -0.41 -5.93 -0.31 7.41e-9 Height; LUSC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg00522288 chr12:125625016 AACS 0.33 6.34 0.33 7.53e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14240646 chr10:27532245 ACBD5 -0.74 -8.16 -0.41 6.91e-15 Breast cancer; LUSC cis rs7772486 0.806 rs2247317 chr6:146217570 C/T cg05347473 chr6:146136440 FBXO30 0.48 8.2 0.41 5.16e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs2018683 0.835 rs7782264 chr7:28978986 A/G cg19402173 chr7:128379420 CALU 0.52 8.12 0.41 9.25e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg04851639 chr8:1020857 NA -0.38 -8.15 -0.41 7.25e-15 Schizophrenia; LUSC cis rs1190552 0.846 rs1044503 chr14:102965996 A/G cg18135206 chr14:102964638 TECPR2 0.48 5.89 0.31 9.54e-9 Blood protein levels; LUSC cis rs4727027 0.704 rs7787753 chr7:148901779 A/T cg23158103 chr7:148848205 ZNF398 -0.48 -8.04 -0.4 1.6e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.21 0.37 3.79e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg21171335 chr12:122356390 WDR66 0.65 9.79 0.47 4.74e-20 Mean corpuscular volume; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg19235966 chr1:16173721 SPEN;FLJ37453 -0.5 -6.51 -0.34 2.68e-10 Cognitive function;Information processing speed; LUSC cis rs2730245 0.510 rs2788474 chr7:158649005 T/C cg11984989 chr7:158649758 WDR60 1.08 22.15 0.77 1.57e-67 Height; LUSC cis rs6918586 0.658 rs198856 chr6:26102708 G/A cg17691542 chr6:26056736 HIST1H1C 0.4 5.92 0.31 8.02e-9 Schizophrenia; LUSC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg09085632 chr11:111637200 PPP2R1B -1.03 -16.42 -0.67 8.09e-45 Primary sclerosing cholangitis; LUSC cis rs6840360 1.000 rs2007445 chr4:152600370 C/T cg22705602 chr4:152727874 NA -0.27 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg08999081 chr20:33150536 PIGU -0.54 -10.56 -0.5 1.11e-22 Glomerular filtration rate (creatinine); LUSC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg25456477 chr12:86230367 RASSF9 -0.42 -7.44 -0.38 8.41e-13 Major depressive disorder; LUSC trans rs9929218 0.581 rs4783676 chr16:68801077 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.96 19.57 0.73 2.38e-57 Colorectal cancer; LUSC cis rs17253792 0.915 rs77252471 chr14:56178075 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs9314323 0.767 rs13271042 chr8:26190212 T/G cg13160058 chr8:26243215 BNIP3L -0.39 -6.77 -0.35 5.71e-11 Red cell distribution width; LUSC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg14668632 chr7:2872130 GNA12 -0.44 -6.31 -0.33 8.79e-10 Height; LUSC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg24399712 chr22:39784796 NA -0.61 -10.26 -0.49 1.2e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11098499 0.863 rs2291185 chr4:120434833 C/A cg24375607 chr4:120327624 NA 0.75 11.26 0.52 3.74e-25 Corneal astigmatism; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg26338869 chr17:61819248 STRADA 0.4 5.67 0.3 3.13e-8 Prudent dietary pattern; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg12564285 chr5:131593104 PDLIM4 -0.54 -9.59 -0.46 2.1e-19 Acylcarnitine levels; LUSC cis rs7177699 0.557 rs7178051 chr15:79118296 A/G cg15571903 chr15:79123663 NA 0.33 6.12 0.32 2.61e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11252926 0.510 rs4881371 chr10:554514 G/A cg18196295 chr10:418757 DIP2C 0.37 5.92 0.31 7.86e-9 Psychosis in Alzheimer's disease; LUSC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.12 -0.32 2.55e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6920965 0.602 rs10872302 chr6:126180631 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.42 -6.34 -0.33 7.41e-10 High light scatter reticulocyte count; LUSC cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg23788917 chr6:8435910 SLC35B3 0.51 7.48 0.38 6.83e-13 Motion sickness; LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs57994353 0.578 rs10448340 chr9:139320069 A/C cg14019695 chr9:139328340 INPP5E 0.42 7.25 0.37 2.99e-12 Eosinophil counts;Cutaneous squamous cell carcinoma; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.56 -9.35 -0.46 1.35e-18 Lymphocyte counts; LUSC cis rs7582180 0.764 rs11686293 chr2:100922830 C/T cg08017756 chr2:100939284 LONRF2 -0.46 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9311676 0.656 rs12497250 chr3:58399399 T/C cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 7.12 0.36 6.53e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg26314531 chr2:26401878 FAM59B -0.66 -9.12 -0.45 7.39e-18 Gut microbiome composition (summer); LUSC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg13877915 chr19:58951672 ZNF132 0.47 7.47 0.38 7.19e-13 Uric acid clearance; LUSC cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg17509989 chr5:176798049 RGS14 0.68 11.0 0.52 3.29e-24 Hemoglobin concentration;Hematocrit; LUSC cis rs7267979 1.000 rs1077889 chr20:25267893 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.46 0.75 6.72e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs826838 0.904 rs7973992 chr12:39168233 T/C cg13010199 chr12:38710504 ALG10B 0.7 11.96 0.55 1.08e-27 Heart rate; LUSC cis rs9287719 0.934 rs4622695 chr2:10744327 C/T cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs7582180 0.676 rs1437969 chr2:100983482 A/C cg12002119 chr2:101014098 CHST10 0.35 5.97 0.31 6.02e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg08219700 chr8:58056026 NA 0.65 7.94 0.4 3.02e-14 Developmental language disorder (linguistic errors); LUSC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.74 0.39 1.19e-13 Intelligence (multi-trait analysis); LUSC trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg27661571 chr11:113659931 NA -0.61 -6.92 -0.35 2.35e-11 Hip circumference adjusted for BMI; LUSC cis rs9788682 0.747 rs2938674 chr15:78757913 C/A cg24631222 chr15:78858424 CHRNA5 0.64 8.37 0.42 1.56e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9902453 1.000 rs62070312 chr17:28438877 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.38 0.42 1.49e-15 Coffee consumption (cups per day); LUSC trans rs10221833 0.602 rs355878 chr2:165633029 T/C cg26993132 chr16:89239499 CDH15 0.31 5.97 0.31 6.09e-9 Response to statin therapy; LUSC cis rs2985684 0.846 rs4476096 chr14:50019391 A/C cg04989706 chr14:50066350 PPIL5 -0.47 -6.33 -0.33 7.78e-10 Carotid intima media thickness; LUSC cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg03452623 chr4:187889614 NA 0.83 16.62 0.67 1.21e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg01657329 chr11:68192670 LRP5 0.44 6.57 0.34 1.9e-10 Total body bone mineral density; LUSC cis rs9326248 0.530 rs7112513 chr11:117037361 A/G cg26566898 chr11:117069891 TAGLN 0.43 5.69 0.3 2.72e-8 Blood protein levels; LUSC cis rs2710642 0.886 rs10153716 chr2:63007059 A/G cg17519650 chr2:63277830 OTX1 -0.47 -6.62 -0.34 1.41e-10 LDL cholesterol levels;LDL cholesterol; LUSC trans rs62103177 0.810 rs62103188 chr18:77627661 G/A cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg19812747 chr11:111475976 SIK2 -0.55 -7.96 -0.4 2.75e-14 Primary sclerosing cholangitis; LUSC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg06784218 chr1:46089804 CCDC17 0.53 10.97 0.51 3.94e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg09417038 chr21:47716443 C21orf57 -0.38 -6.0 -0.31 5.17e-9 Testicular germ cell tumor; LUSC cis rs9303401 0.659 rs36109237 chr17:56653834 A/G cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg26528668 chr16:1614120 IFT140 0.41 6.79 0.35 5.11e-11 Coronary artery disease; LUSC cis rs977987 0.750 rs4888414 chr16:75447233 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.62 -0.34 1.4e-10 Dupuytren's disease; LUSC cis rs12681287 0.640 rs7461413 chr8:87470978 C/G cg27223183 chr8:87520930 FAM82B -0.54 -7.45 -0.38 7.92e-13 Caudate activity during reward; LUSC cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg04013166 chr16:89971882 TCF25 0.59 5.87 0.31 1.04e-8 Skin colour saturation; LUSC cis rs4812048 1.000 rs4812048 chr20:57587771 C/T cg14073986 chr20:57617431 SLMO2 0.6 6.56 0.34 2.08e-10 Mean platelet volume; LUSC cis rs1670533 0.932 rs935968 chr4:1063187 G/T cg27284194 chr4:1044797 NA 0.63 9.21 0.45 3.82e-18 Recombination rate (females); LUSC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg23625390 chr15:77176239 SCAPER 0.46 7.0 0.36 1.44e-11 Blood metabolite levels; LUSC trans rs7829975 0.660 rs10093926 chr8:8549020 A/C cg27411982 chr8:10470053 RP1L1 -0.39 -6.09 -0.32 3.15e-9 Mood instability; LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg04944784 chr2:26401820 FAM59B 0.74 10.59 0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg08888203 chr3:10149979 C3orf24 0.66 9.08 0.45 9.57e-18 Alzheimer's disease; LUSC cis rs6665290 0.904 rs2297416 chr1:227172935 C/G cg10327440 chr1:227177885 CDC42BPA -1.23 -39.3 -0.91 2.68e-127 Myeloid white cell count; LUSC trans rs9393777 0.622 rs13191326 chr6:27031029 A/G cg06606381 chr12:133084897 FBRSL1 -0.69 -7.18 -0.37 4.68e-12 Intelligence (multi-trait analysis); LUSC cis rs2985684 0.894 rs2281837 chr14:50065359 C/G cg04989706 chr14:50066350 PPIL5 -0.48 -6.36 -0.33 6.83e-10 Carotid intima media thickness; LUSC trans rs853679 0.607 rs61742093 chr6:27879982 A/G cg01620082 chr3:125678407 NA -0.83 -7.18 -0.37 4.64e-12 Depression; LUSC cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg15309053 chr8:964076 NA 0.34 7.04 0.36 1.09e-11 Schizophrenia; LUSC cis rs908922 0.676 rs7518654 chr1:152517845 C/G cg20991723 chr1:152506922 NA 0.47 8.46 0.42 8.41e-16 Hair morphology; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.69 10.62 0.5 7.09e-23 Lymphocyte counts; LUSC cis rs1577917 0.958 rs4707229 chr6:86546237 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.99 -0.44 1.88e-17 Response to antipsychotic treatment; LUSC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.0 -0.36 1.44e-11 Alzheimer's disease (late onset); LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg16132339 chr22:24313637 DDTL;DDT 0.41 6.44 0.33 4.2e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg06634786 chr22:41940651 POLR3H -0.5 -6.26 -0.32 1.17e-9 Vitiligo; LUSC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg08219700 chr8:58056026 NA 0.46 6.04 0.31 4.12e-9 Developmental language disorder (linguistic errors); LUSC cis rs62432291 0.681 rs3003174 chr6:159655326 T/C cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC trans rs3857536 0.813 rs1891599 chr6:66941699 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -5.99 -0.31 5.53e-9 Blood trace element (Cu levels); LUSC cis rs2273669 0.667 rs12210444 chr6:109305743 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11940773 chr11:63606512 MARK2 0.41 6.05 0.31 3.82e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs73206853 0.563 rs73194043 chr12:111188782 G/A cg12870014 chr12:110450643 ANKRD13A 0.66 6.91 0.35 2.49e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs7937682 0.889 rs559482 chr11:111497902 G/A cg18187862 chr3:45730750 SACM1L 0.57 7.2 0.37 4.05e-12 Primary sclerosing cholangitis; LUSC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg09044154 chr16:88155775 NA -0.56 -7.56 -0.38 3.96e-13 Menopause (age at onset); LUSC cis rs11112613 0.653 rs2374533 chr12:106047891 A/G cg03607813 chr12:105948248 NA 0.62 7.69 0.39 1.7e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs208520 0.661 rs6937856 chr6:66867468 A/G cg07460842 chr6:66804631 NA -1.14 -17.9 -0.7 1.07e-50 Exhaled nitric oxide output; LUSC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg18357645 chr12:58087776 OS9 -0.5 -6.66 -0.34 1.12e-10 Multiple sclerosis; LUSC cis rs7666738 0.546 rs7699578 chr4:98838893 T/C cg05340658 chr4:99064831 C4orf37 0.65 8.88 0.44 4.04e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs4888262 0.526 rs7205258 chr16:74642539 C/T cg01733217 chr16:74700730 RFWD3 0.79 13.26 0.59 1.56e-32 Testicular germ cell tumor; LUSC cis rs9467773 0.620 rs2451741 chr6:26629404 A/G cg05738196 chr6:26577821 NA 0.79 14.93 0.63 5.67e-39 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2491412 chr1:231535880 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.71 -0.47 8.8e-20 Hemoglobin concentration; LUSC cis rs7605827 0.836 rs2052436 chr2:15697518 T/C cg19274914 chr2:15703543 NA 0.45 8.43 0.42 1.02e-15 Educational attainment (years of education); LUSC cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg22709100 chr7:91322751 NA 0.39 5.74 0.3 2.13e-8 Breast cancer; LUSC cis rs868036 0.645 rs4776987 chr15:68123915 A/T cg08079166 chr15:68083412 MAP2K5 -0.44 -7.3 -0.37 2.08e-12 Restless legs syndrome; LUSC cis rs1003719 0.762 rs11088381 chr21:38478429 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.71 11.54 0.53 3.88e-26 Eye color traits; LUSC trans rs61931739 1.000 rs12298806 chr12:34036528 C/G cg26384229 chr12:38710491 ALG10B -0.51 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.78 -0.57 1.02e-30 Platelet count; LUSC cis rs62400317 0.762 rs12208605 chr6:44963735 A/C cg18551225 chr6:44695536 NA 0.44 6.94 0.36 1.99e-11 Total body bone mineral density; LUSC cis rs7666738 0.546 rs2098935 chr4:98914376 A/G cg05340658 chr4:99064831 C4orf37 0.57 8.81 0.43 7.13e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25654301 chr17:73511699 TSEN54;CASKIN2 0.4 6.63 0.34 1.36e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7168353 0.519 rs725458 chr15:93634933 A/G cg12595281 chr15:93633172 RGMA -0.31 -5.68 -0.3 2.92e-8 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs11864453 0.793 rs7197869 chr16:72079352 G/C cg23815491 chr16:72088622 HP 0.38 6.6 0.34 1.59e-10 Fibrinogen levels; LUSC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg17264618 chr3:40429014 ENTPD3 0.36 7.48 0.38 6.7e-13 Renal cell carcinoma; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg02475777 chr4:1388615 CRIPAK -0.58 -8.56 -0.42 4.23e-16 Obesity-related traits; LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg20295408 chr7:1910781 MAD1L1 -0.55 -8.09 -0.4 1.15e-14 Bipolar disorder and schizophrenia; LUSC cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg16482183 chr6:26056742 HIST1H1C 0.47 6.93 0.35 2.11e-11 Height; LUSC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg08975724 chr8:8085496 FLJ10661 -0.49 -7.56 -0.38 3.83e-13 Mood instability; LUSC cis rs500891 0.574 rs3798887 chr6:84121713 C/G cg08257003 chr6:84140564 ME1 0.35 8.49 0.42 6.79e-16 Platelet-derived growth factor BB levels; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.71 10.68 0.5 4.34e-23 Lymphocyte counts; LUSC cis rs11098499 0.863 rs28718422 chr4:120466304 C/A cg09307838 chr4:120376055 NA 0.76 11.04 0.52 2.31e-24 Corneal astigmatism; LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg04234412 chr22:24373322 LOC391322 -0.8 -13.38 -0.59 5.7e-33 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6543140 0.964 rs6734203 chr2:103080066 G/C cg09003973 chr2:102972529 NA 0.54 6.87 0.35 3.16e-11 Blood protein levels; LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg00166722 chr3:10149974 C3orf24 0.56 7.54 0.38 4.61e-13 Alzheimer's disease; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg10729496 chr3:10149963 C3orf24 0.55 7.57 0.38 3.79e-13 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23097686 chr12:98910128 TMPO;LOC100128191 0.38 5.97 0.31 6.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6961069 0.503 rs3211816 chr7:80277990 G/A cg04458919 chr7:80252533 CD36 -0.4 -6.79 -0.35 5.28e-11 Platelet count; LUSC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg05855489 chr10:104503620 C10orf26 -0.62 -8.31 -0.41 2.49e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg01341218 chr17:43662625 NA 0.77 11.23 0.52 5.03e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs12210905 0.841 rs28410967 chr6:27265235 T/C cg11837749 chr1:55047332 ACOT11 0.66 6.3 0.33 9.13e-10 Hip circumference adjusted for BMI; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.51 9.12 0.45 7.04e-18 Bipolar disorder; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg04858616 chr1:40255010 BMP8B 0.42 5.96 0.31 6.37e-9 Mosquito bite size; LUSC cis rs3540 0.574 rs2526000 chr15:90962626 C/T cg03599575 chr15:90893182 GABARAPL3 0.33 5.81 0.3 1.47e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg20891558 chr2:74357851 NA 0.78 13.07 0.58 8.17e-32 Gestational age at birth (maternal effect); LUSC cis rs35883536 0.647 rs10493929 chr1:101043928 A/C cg06223162 chr1:101003688 GPR88 -0.49 -9.35 -0.46 1.34e-18 Monocyte count; LUSC cis rs4493873 0.731 rs34250051 chr8:92047462 G/A cg16814680 chr8:91681699 NA 0.41 5.67 0.3 3.08e-8 Migraine - clinic-based; LUSC cis rs7107174 1.000 rs2511169 chr11:77965321 T/C cg02023728 chr11:77925099 USP35 0.47 7.09 0.36 7.86e-12 Testicular germ cell tumor; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15450734 chr14:103541957 NA 0.43 6.25 0.32 1.26e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs113835537 0.529 rs57724777 chr11:66236431 G/A cg24851651 chr11:66362959 CCS 0.55 8.0 0.4 2.14e-14 Airway imaging phenotypes; LUSC cis rs2839186 0.814 rs2276257 chr21:47711229 A/G cg05896524 chr21:47604654 C21orf56 0.4 5.86 0.31 1.09e-8 Testicular germ cell tumor; LUSC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg26441486 chr22:50317300 CRELD2 0.48 7.24 0.37 3.09e-12 Schizophrenia; LUSC cis rs11997175 0.653 rs7817167 chr8:33633088 A/C ch.8.33884649F chr8:33765107 NA 0.48 7.78 0.39 9.25e-14 Body mass index; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg27094323 chr7:1216898 NA -0.36 -6.27 -0.32 1.09e-9 Longevity;Endometriosis; LUSC trans rs11098499 0.909 rs79026312 chr4:120440677 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.57 0.34 1.9e-10 Corneal astigmatism; LUSC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg18225595 chr11:63971243 STIP1 0.63 10.94 0.51 4.98e-24 Platelet count; LUSC cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14240646 chr10:27532245 ACBD5 0.71 8.21 0.41 4.81e-15 Breast cancer; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg01441114 chr19:12900873 JUNB 0.34 6.04 0.31 4.03e-9 Metabolite levels (Pyroglutamine); LUSC cis rs4680 0.737 rs2239393 chr22:19950428 A/G cg06346307 chr22:19949965 COMT -0.34 -7.03 -0.36 1.18e-11 Blood metabolite levels; LUSC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg05084668 chr3:125655381 ALG1L -0.5 -7.06 -0.36 1e-11 Blood pressure (smoking interaction); LUSC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg21644426 chr2:191273491 MFSD6 0.63 9.79 0.47 4.47e-20 Pulse pressure; LUSC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg12560992 chr17:57184187 TRIM37 -0.86 -16.48 -0.67 4.69e-45 Intelligence (multi-trait analysis); LUSC trans rs7939886 0.920 rs11227372 chr11:55919682 C/A cg15704280 chr7:45808275 SEPT13 0.83 6.68 0.34 9.95e-11 Myopia (pathological); LUSC cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg22601191 chr20:60968625 CABLES2 0.55 9.59 0.46 2.16e-19 Colorectal cancer; LUSC cis rs12464559 0.522 rs13016166 chr2:152624144 G/A cg01189475 chr2:152685088 ARL5A 0.67 7.42 0.38 9.53e-13 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs7681440 0.874 rs1372522 chr4:90765280 A/G cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg20848291 chr7:100343083 ZAN -0.51 -6.25 -0.32 1.26e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg15445000 chr17:37608096 MED1 0.4 6.77 0.35 5.76e-11 Glomerular filtration rate (creatinine); LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg14159672 chr1:205819179 PM20D1 0.73 12.1 0.55 3.42e-28 Menarche (age at onset); LUSC cis rs7833986 1.000 rs34608229 chr8:57097017 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.63 9.35 0.46 1.28e-18 Height; LUSC cis rs2404602 0.716 rs2404736 chr15:76875943 T/C cg23625390 chr15:77176239 SCAPER 0.48 7.44 0.38 8.73e-13 Blood metabolite levels; LUSC cis rs2933343 0.700 rs789233 chr3:128603150 G/T cg11901034 chr3:128598214 ACAD9 -0.41 -6.55 -0.34 2.19e-10 IgG glycosylation; LUSC cis rs2247341 0.577 rs2236996 chr4:1703646 A/G cg05874882 chr4:1763078 NA -0.32 -5.99 -0.31 5.53e-9 Hip circumference adjusted for BMI;Height; LUSC cis rs12410462 0.581 rs35141785 chr1:227553496 G/C cg23173402 chr1:227635558 NA 0.54 6.34 0.33 7.55e-10 Major depressive disorder; LUSC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg14949292 chr17:78079608 GAA -0.31 -5.89 -0.31 9.53e-9 Yeast infection; LUSC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.17e-8 Eye color traits; LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg10729496 chr3:10149963 C3orf24 0.52 6.88 0.35 2.9100000000000002e-11 Alzheimer's disease; LUSC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.49 0.46 4.39e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9914988 0.943 rs7211502 chr17:27163295 C/A cg09479241 chr17:27052676 TLCD1 0.43 5.93 0.31 7.57e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs734999 0.588 rs745368 chr1:2524205 C/T cg18932078 chr1:2524107 MMEL1 0.32 7.12 0.36 6.57e-12 Ulcerative colitis; LUSC cis rs11167764 1.000 rs3761757 chr5:141488219 A/C cg08523384 chr5:141488047 NDFIP1 -0.48 -6.88 -0.35 3.03e-11 Crohn's disease; LUSC cis rs12681287 0.640 rs13282351 chr8:87484669 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg05313129 chr8:58192883 C8orf71 -0.51 -6.61 -0.34 1.52e-10 Developmental language disorder (linguistic errors); LUSC cis rs7553864 0.667 rs10873820 chr1:87605973 C/G cg17420885 chr1:87600446 LOC339524 0.46 6.44 0.33 4.16e-10 Smoking behavior; LUSC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg18904891 chr8:8559673 CLDN23 -0.62 -8.58 -0.43 3.55e-16 Obesity-related traits; LUSC cis rs10788972 0.903 rs7537946 chr1:54538700 A/G cg25741118 chr1:54482237 LDLRAD1 -0.27 -6.03 -0.31 4.39e-9 Parkinson disease and lewy body pathology; LUSC cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg23711669 chr6:146136114 FBXO30 0.76 13.72 0.6 2.76e-34 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07981364 chr11:47448113 PSMC3 -0.46 -6.77 -0.35 5.69e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.41 0.33 4.97e-10 Menopause (age at onset); LUSC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg12292205 chr6:26970375 C6orf41 -0.7 -12.22 -0.56 1.23e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.83 -0.54 3.32e-27 Chronic sinus infection; LUSC cis rs6084875 0.840 rs1999664 chr20:4721148 C/T cg07258627 chr20:4721683 PRNT -0.35 -6.21 -0.32 1.6e-9 Systemic lupus erythematosus; LUSC cis rs796364 0.616 rs7589545 chr2:200676102 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.97 0.31 6.22e-9 Schizophrenia; LUSC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.04 0.36 1.07e-11 Schizophrenia; LUSC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.49e-11 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.68 -0.39 1.81e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7267979 1.000 rs2259956 chr20:25282433 A/G cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7819412 0.527 rs7821914 chr8:10805015 A/G cg21775007 chr8:11205619 TDH -0.4 -5.94 -0.31 7.09e-9 Triglycerides; LUSC cis rs17604090 0.938 rs10276157 chr7:29665016 A/G cg19413766 chr7:29689036 LOC646762 -0.58 -6.65 -0.34 1.17e-10 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg08200582 chr11:442649 ANO9 -0.52 -5.95 -0.31 6.84e-9 Body mass index; LUSC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg03785755 chr6:26196794 NA 0.54 5.7 0.3 2.62e-8 Gout;Renal underexcretion gout; LUSC cis rs7312933 0.702 rs10785333 chr12:42586470 A/G cg17420585 chr12:42539391 GXYLT1 0.35 6.57 0.34 1.88e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2625529 0.667 rs16956381 chr15:72193237 A/C cg16672083 chr15:72433130 SENP8 -0.51 -7.4 -0.38 1.13e-12 Red blood cell count; LUSC cis rs722599 0.651 rs12887044 chr14:75255659 C/T cg08847533 chr14:75593920 NEK9 0.43 6.02 0.31 4.55e-9 IgG glycosylation; LUSC cis rs9303401 0.659 rs17822807 chr17:56687190 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.72 0.57 1.68e-30 Cognitive test performance; LUSC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg26380479 chr7:97908229 NA -0.27 -6.08 -0.32 3.21e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg08219700 chr8:58056026 NA 0.56 7.5 0.38 6e-13 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.516 rs8044995 chr16:68189340 G/A cg05110241 chr16:68378359 PRMT7 -0.49 -6.31 -0.33 9.09e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.4 -0.42 1.29e-15 Lung cancer; LUSC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg23711669 chr6:146136114 FBXO30 -0.9 -17.4 -0.69 9.72e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg25173405 chr17:45401733 C17orf57 -0.4 -5.84 -0.3 1.24e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4601821 1.000 rs6589375 chr11:113255111 C/A cg14159747 chr11:113255604 NA 0.25 6.01 0.31 4.95e-9 Alcoholic chronic pancreatitis; LUSC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg06636001 chr8:8085503 FLJ10661 -0.62 -9.63 -0.47 1.51e-19 Mood instability; LUSC cis rs611744 0.870 rs650925 chr8:109196725 T/C cg18478394 chr8:109455254 TTC35 0.4 5.95 0.31 6.61e-9 Dupuytren's disease; LUSC cis rs4595586 0.545 rs11615584 chr12:39409350 C/G cg26384229 chr12:38710491 ALG10B 0.56 7.83 0.39 6.44e-14 Morning vs. evening chronotype; LUSC cis rs6426558 0.537 rs2492630 chr1:227286931 A/G cg10327440 chr1:227177885 CDC42BPA 0.54 7.34 0.37 1.62e-12 Neutrophil percentage of white cells; LUSC cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg01119278 chr6:110721349 DDO -0.48 -8.71 -0.43 1.45e-16 Platelet distribution width; LUSC cis rs10779751 1.000 rs11121711 chr1:11317661 A/T cg08854313 chr1:11322531 MTOR 0.89 15.01 0.63 2.78e-39 Body mass index; LUSC trans rs2204008 0.715 rs11514342 chr12:38236710 T/A cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.38e-9 Bladder cancer; LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg16362232 chr11:430036 ANO9 0.62 7.91 0.4 3.86e-14 Body mass index; LUSC cis rs4654899 0.931 rs7520481 chr1:21140385 T/G cg01072550 chr1:21505969 NA 0.49 7.38 0.37 1.3e-12 Superior frontal gyrus grey matter volume; LUSC cis rs614226 1.000 rs1167727 chr12:120965508 C/A cg27489772 chr12:121021490 NA 0.58 7.78 0.39 9.08e-14 Type 1 diabetes nephropathy; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.69 -8.59 -0.43 3.31e-16 Glomerular filtration rate in chronic kidney disease; LUSC cis rs12541635 0.653 rs7014265 chr8:107026412 G/A cg10147462 chr8:107024639 NA 0.66 13.63 0.6 6.35e-34 Age of smoking initiation; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg08200582 chr11:442649 ANO9 -0.52 -5.67 -0.3 3.03e-8 Body mass index; LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg13395646 chr4:1353034 KIAA1530 0.54 7.65 0.39 2.21e-13 Longevity; LUSC cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg22709100 chr7:91322751 NA 0.41 5.91 0.31 8.64e-9 Breast cancer; LUSC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg25427524 chr10:38739819 LOC399744 -0.58 -10.33 -0.49 6.63e-22 Extrinsic epigenetic age acceleration; LUSC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg26441486 chr22:50317300 CRELD2 0.52 7.98 0.4 2.42e-14 Schizophrenia; LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg08859206 chr1:53392774 SCP2 -0.55 -9.61 -0.47 1.81e-19 Monocyte count; LUSC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg10523679 chr1:76189770 ACADM 0.89 15.49 0.65 3.73e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg06634786 chr22:41940651 POLR3H 0.49 6.17 0.32 1.99e-9 Vitiligo; LUSC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.54 0.34 2.29e-10 Lung cancer; LUSC cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.07 0.48 5.33e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs79349575 0.783 rs318090 chr17:46991752 G/A cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg07507251 chr3:52567010 NT5DC2 0.36 6.55 0.34 2.21e-10 Bipolar disorder; LUSC cis rs8180040 0.932 rs1038394 chr3:47464122 A/G cg16586182 chr3:47516702 SCAP -0.5 -7.88 -0.4 4.76e-14 Colorectal cancer; LUSC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg12463550 chr7:65579703 CRCP -0.63 -5.68 -0.3 2.92e-8 Diabetic kidney disease; LUSC cis rs7940866 0.801 rs10894296 chr11:130840433 T/G cg12179176 chr11:130786555 SNX19 0.6 9.01 0.44 1.63e-17 Schizophrenia; LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg00149659 chr3:10157352 C3orf10 0.91 12.92 0.58 3.1e-31 Alzheimer's disease; LUSC trans rs61931739 0.513 rs10743833 chr12:33897481 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.85 0.39 5.9e-14 Morning vs. evening chronotype; LUSC cis rs12421382 0.659 rs11213103 chr11:109385935 A/G cg11473876 chr11:109292803 C11orf87 0.42 6.96 0.36 1.8e-11 Schizophrenia; LUSC cis rs7771547 0.519 rs12663882 chr6:36362441 G/T cg07856975 chr6:36356162 ETV7 -0.44 -6.79 -0.35 5.22e-11 Platelet distribution width; LUSC cis rs4268898 0.552 rs11125444 chr2:24367205 G/T cg06627628 chr2:24431161 ITSN2 0.52 7.34 0.37 1.66e-12 Asthma; LUSC cis rs11190604 1.000 rs75063298 chr10:102213600 C/A cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg26354017 chr1:205819088 PM20D1 -0.41 -5.96 -0.31 6.43e-9 Menarche (age at onset); LUSC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18099408 chr3:52552593 STAB1 -0.42 -7.38 -0.37 1.24e-12 Electroencephalogram traits; LUSC cis rs6484504 0.576 rs208083 chr11:31196880 C/T cg26647111 chr11:31128758 NA -0.41 -5.95 -0.31 6.95e-9 Red blood cell count; LUSC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg14552801 chr7:65878734 NA 0.44 6.21 0.32 1.53e-9 Aortic root size; LUSC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg09263875 chr16:632152 PIGQ 0.66 11.79 0.54 4.63e-27 Height; LUSC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg11812906 chr14:75593930 NEK9 0.65 10.7 0.51 3.58e-23 Height; LUSC cis rs7264396 0.580 rs6060648 chr20:34456704 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.48 -0.33 3.29e-10 Total cholesterol levels; LUSC trans rs1728785 1.000 rs698717 chr16:68560199 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.68 0.39 1.77e-13 Ulcerative colitis; LUSC cis rs1023500 0.506 rs6002625 chr22:42517689 A/G cg04733989 chr22:42467013 NAGA -0.64 -9.85 -0.47 2.88e-20 Schizophrenia; LUSC cis rs7772486 0.875 rs2748497 chr6:146319417 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.21 -0.37 3.84e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs9860340 0.730 rs4858965 chr3:87640363 C/T cg03644585 chr7:884825 UNC84A 0.42 6.03 0.31 4.35e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.31 -5.82 -0.3 1.36e-8 IgG glycosylation; LUSC cis rs11971779 0.585 rs3922848 chr7:139046210 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC trans rs6502050 0.835 rs4789677 chr17:80119842 A/G cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg16405210 chr4:1374714 KIAA1530 -0.86 -14.13 -0.61 7.37e-36 Longevity; LUSC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs7241530 0.560 rs8094722 chr18:75904415 C/A cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg02487422 chr3:49467188 NICN1 0.48 7.59 0.38 3.32e-13 Resting heart rate; LUSC cis rs10845606 1.000 rs10845609 chr12:12838920 T/A cg09462578 chr12:12878428 APOLD1 -0.53 -6.49 -0.33 3.01e-10 Systemic lupus erythematosus; LUSC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg07636037 chr3:49044803 WDR6 1.02 17.66 0.69 9.6e-50 Parkinson's disease; LUSC trans rs3824660 0.591 rs3781094 chr10:8101427 G/T cg15569512 chr14:104029667 BAG5;C14orf153 0.51 6.47 0.33 3.59e-10 Rheumatoid arthritis; LUSC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.69 -0.3 2.78e-8 Depression; LUSC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08109568 chr15:31115862 NA -0.58 -8.19 -0.41 5.47e-15 Huntington's disease progression; LUSC cis rs12579753 0.917 rs7138895 chr12:82203280 T/G cg07988820 chr12:82153109 PPFIA2 -0.42 -6.04 -0.31 4.05e-9 Resting heart rate; LUSC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg24562669 chr7:97807699 LMTK2 0.34 6.06 0.31 3.74e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2762353 0.935 rs1165213 chr6:25799676 A/G cg03517284 chr6:25882590 NA 0.42 7.54 0.38 4.49e-13 Blood metabolite levels; LUSC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg15448220 chr1:150897856 SETDB1 0.41 5.96 0.31 6.29e-9 Melanoma; LUSC cis rs1215050 0.791 rs260893 chr4:98744785 A/C cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.25e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9650315 0.866 rs4623388 chr8:57190484 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg11941060 chr3:133502564 NA -0.52 -8.07 -0.4 1.25e-14 Iron status biomarkers; LUSC cis rs12893668 0.703 rs2274267 chr14:104029449 G/A cg04998671 chr14:104000505 TRMT61A -0.46 -6.63 -0.34 1.35e-10 Reticulocyte count; LUSC cis rs11208691 0.513 rs1938484 chr1:66081282 C/A cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 Lymphocyte percentage of white cells; LUSC cis rs559928 0.947 rs10792430 chr11:64147114 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.64 6.58 0.34 1.83e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC trans rs9380880 0.826 rs12175102 chr6:39554898 C/T cg12580580 chr10:74544059 CCDC109A -0.53 -6.24 -0.32 1.3e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.01 0.36 1.31e-11 Blood metabolite levels; LUSC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg09035930 chr12:129282057 SLC15A4 0.64 12.74 0.57 1.37e-30 Systemic lupus erythematosus; LUSC cis rs6752107 1.000 rs3828309 chr2:234180410 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.68 -11.29 -0.53 2.93e-25 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7572644 0.739 rs6547815 chr2:28155195 T/A cg27432699 chr2:27873401 GPN1 -0.52 -6.81 -0.35 4.48e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs295140 1.000 rs4516413 chr2:201163920 T/C cg04283868 chr2:201171347 SPATS2L 0.43 6.52 0.34 2.67e-10 QT interval; LUSC trans rs3857536 0.813 rs6455084 chr6:66935658 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19622078 chr1:28157351 PPP1R8 -0.4 -6.07 -0.32 3.4e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg16230307 chr14:35515116 FAM177A1 0.79 10.01 0.48 8.4e-21 Psoriasis; LUSC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg13395646 chr4:1353034 KIAA1530 -0.58 -9.24 -0.45 2.91e-18 Longevity; LUSC cis rs8030485 0.716 rs12899109 chr15:79410970 T/C cg17916960 chr15:79447300 NA 0.34 6.13 0.32 2.51e-9 Left ventricle wall thickness; LUSC cis rs11674184 0.659 rs59129126 chr2:11728388 T/C cg07314298 chr2:11723111 GREB1 -0.8 -15.11 -0.64 1.12e-39 Endometriosis; LUSC cis rs17604090 0.793 rs73687726 chr7:29688773 T/C cg19413766 chr7:29689036 LOC646762 -0.56 -7.01 -0.36 1.36e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs17433780 0.836 rs17434342 chr1:89505742 C/G cg09516651 chr1:89888402 LOC400759 -0.55 -10.52 -0.5 1.53e-22 Carotid intima media thickness; LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg16362232 chr11:430036 ANO9 0.67 8.57 0.42 3.91e-16 Body mass index; LUSC cis rs782590 0.764 rs2586969 chr2:55829392 G/C cg18811423 chr2:55921094 PNPT1 0.77 12.74 0.57 1.43e-30 Metabolic syndrome; LUSC cis rs3087591 1.000 rs1800845 chr17:29703438 C/G cg24425628 chr17:29625626 OMG;NF1 -0.59 -8.33 -0.41 2.05e-15 Hip circumference; LUSC cis rs10751667 1.000 rs6597972 chr11:928402 C/T ch.11.42038R chr11:967971 AP2A2 0.54 8.09 0.4 1.1e-14 Alzheimer's disease (late onset); LUSC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs8062405 1.000 rs62036657 chr16:28844365 G/A cg09754948 chr16:28834200 ATXN2L 0.41 6.12 0.32 2.63e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs67981189 0.634 rs221900 chr14:71604354 C/T cg07012739 chr14:71606506 NA 0.33 5.84 0.3 1.24e-8 Schizophrenia; LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg16145915 chr7:1198662 ZFAND2A -0.43 -7.7 -0.39 1.51e-13 Longevity;Endometriosis; LUSC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg01879757 chr17:41196368 BRCA1 -0.48 -7.44 -0.38 8.51e-13 Menopause (age at onset); LUSC cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg19812747 chr11:111475976 SIK2 -0.47 -6.35 -0.33 7.16e-10 Primary sclerosing cholangitis; LUSC cis rs68170813 0.559 rs75672288 chr7:107031549 G/C cg02696742 chr7:106810147 HBP1 -0.64 -9.27 -0.45 2.34e-18 Coronary artery disease; LUSC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg12560992 chr17:57184187 TRIM37 -0.85 -15.3 -0.64 2.01e-40 Intelligence (multi-trait analysis); LUSC cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg16586182 chr3:47516702 SCAP -0.52 -8.11 -0.41 1e-14 Colorectal cancer; LUSC cis rs2637266 1.000 rs7475686 chr10:78358761 T/C cg18941641 chr10:78392320 NA 0.38 7.01 0.36 1.35e-11 Pulmonary function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26546685 chr4:100870642 LOC256880;H2AFZ -0.4 -6.04 -0.31 4.04e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2439831 1.000 rs689647 chr15:43762196 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg18512352 chr11:47633146 NA -0.46 -9.02 -0.44 1.51e-17 Subjective well-being; LUSC cis rs8141529 0.778 rs9625566 chr22:29162506 G/A cg02153584 chr22:29168773 CCDC117 0.67 10.12 0.48 3.44e-21 Lymphocyte counts; LUSC cis rs7799006 0.527 rs6967286 chr7:2212758 C/A cg21782813 chr7:2030301 MAD1L1 0.38 6.31 0.33 8.87e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7589342 0.566 rs11890447 chr2:106389691 T/C cg14210321 chr2:106509881 NCK2 -0.41 -5.89 -0.31 9.28e-9 Addiction; LUSC cis rs8017423 0.740 rs8003095 chr14:90680643 A/T cg04374321 chr14:90722782 PSMC1 0.7 11.18 0.52 7.29e-25 Mortality in heart failure; LUSC cis rs599083 0.573 rs3018713 chr11:68390986 A/G cg16797656 chr11:68205561 LRP5 0.34 5.85 0.31 1.14e-8 Bone mineral density (spine); LUSC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg23719950 chr11:63933701 MACROD1 -0.62 -8.07 -0.4 1.26e-14 Mean platelet volume; LUSC cis rs694739 0.964 rs2510066 chr11:64052447 C/T cg02228329 chr11:64053129 BAD;GPR137 0.52 7.5 0.38 5.9e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg16362232 chr11:430036 ANO9 0.61 7.98 0.4 2.43e-14 Body mass index; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg09877947 chr5:131593287 PDLIM4 0.47 7.33 0.37 1.72e-12 Breast cancer; LUSC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg17971929 chr21:40555470 PSMG1 -0.65 -10.62 -0.5 6.76e-23 Cognitive function; LUSC trans rs4942242 0.663 rs1390371 chr13:44211727 A/G cg19169023 chr15:41853346 TYRO3 0.57 8.65 0.43 2.16e-16 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg24846343 chr22:24311635 DDTL 0.77 17.79 0.7 2.91e-50 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2637266 0.935 rs2583053 chr10:78402416 A/G cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs6424115 0.760 rs2999566 chr1:24051124 A/G cg15997130 chr1:24165203 NA 0.37 5.7 0.3 2.58e-8 Immature fraction of reticulocytes; LUSC cis rs7808935 1.000 rs7808935 chr7:27977363 T/C cg22168087 chr7:27702803 HIBADH 0.52 6.54 0.34 2.29e-10 Prostate cancer; LUSC cis rs3126085 0.935 rs991231 chr1:152211898 T/G cg26876637 chr1:152193138 HRNR -0.46 -6.37 -0.33 6.38e-10 Atopic dermatitis; LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg08280861 chr8:58055591 NA 0.56 5.98 0.31 5.87e-9 Developmental language disorder (linguistic errors); LUSC cis rs7937682 0.921 rs1944119 chr11:111436387 A/G cg09085632 chr11:111637200 PPP2R1B 0.96 13.42 0.59 3.8e-33 Primary sclerosing cholangitis; LUSC cis rs1577917 0.958 rs12198971 chr6:86525445 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs10782582 0.609 rs112431348 chr1:76275571 A/G cg10523679 chr1:76189770 ACADM -0.46 -6.67 -0.34 1.09e-10 Daytime sleep phenotypes; LUSC cis rs6964587 1.000 rs6951972 chr7:91689446 T/G cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.52 7.16 0.36 5.17e-12 Tuberculosis; LUSC trans rs67539049 1.000 rs67932868 chr8:11303445 G/A cg26241650 chr22:40417538 FAM83F 0.43 5.99 0.31 5.54e-9 Itch intensity from mosquito bite; LUSC cis rs1865760 0.519 rs2275904 chr6:25768085 T/C cg16482183 chr6:26056742 HIST1H1C 0.61 8.25 0.41 3.75e-15 Height; LUSC cis rs9788682 1.000 rs61204066 chr15:78815298 G/A cg24631222 chr15:78858424 CHRNA5 0.83 11.47 0.53 6.47e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg26335602 chr6:28129616 ZNF389 0.49 6.69 0.34 9.67e-11 Parkinson's disease; LUSC cis rs17401966 1.000 rs17411502 chr1:10431158 T/C cg19773385 chr1:10388646 KIF1B -0.53 -8.33 -0.41 2.07e-15 Hepatocellular carcinoma; LUSC cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.93 0.44 2.82e-17 Motion sickness; LUSC cis rs6692729 0.901 rs1295638 chr1:227069267 A/G cg10327440 chr1:227177885 CDC42BPA -0.51 -7.32 -0.37 1.91e-12 Electrodermal activity; LUSC cis rs2282300 0.739 rs34234618 chr11:30241701 T/C cg25418670 chr11:30344373 C11orf46 -0.66 -9.53 -0.46 3.4e-19 Morning vs. evening chronotype; LUSC cis rs478304 0.934 rs669742 chr11:65501291 C/T cg27068330 chr11:65405492 SIPA1 0.61 9.26 0.45 2.6e-18 Acne (severe); LUSC cis rs9796 0.576 rs13329511 chr15:41299121 T/C cg18705301 chr15:41695430 NDUFAF1 -0.55 -9.37 -0.46 1.11e-18 Menopause (age at onset); LUSC trans rs11935423 0.778 rs1800591 chr4:100495488 G/T cg02164153 chr5:172068145 NEURL1B -0.47 -6.1 -0.32 3e-9 Gut microbiome composition (summer); LUSC cis rs12597458 0.752 rs8051239 chr16:72036257 T/A cg01557791 chr16:72042693 DHODH 0.57 9.13 0.45 6.88e-18 Prostate cancer; LUSC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg16339924 chr4:17578868 LAP3 0.49 7.54 0.38 4.54e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.812 rs73077358 chr3:41850005 C/T cg03022575 chr3:42003672 ULK4 0.86 8.66 0.43 2.07e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs941408 0.515 rs4624312 chr19:2774460 T/C cg06609049 chr19:2785107 THOP1 1.12 22.02 0.77 4.98e-67 Total cholesterol levels; LUSC cis rs34779708 0.931 rs7099036 chr10:35349574 C/T cg03585969 chr10:35415529 CREM 0.6 8.73 0.43 1.23e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC cis rs7582180 0.790 rs13020451 chr2:100927131 T/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.46 -0.42 8.2e-16 Intelligence (multi-trait analysis); LUSC cis rs1790761 0.607 rs656652 chr11:67343957 C/T cg24690094 chr11:67383802 NA 0.43 8.47 0.42 7.8e-16 Mean corpuscular volume; LUSC cis rs11098499 0.908 rs11098527 chr4:120399906 A/G cg24375607 chr4:120327624 NA 0.79 11.63 0.54 1.73e-26 Corneal astigmatism; LUSC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg06494592 chr3:125709126 NA -0.52 -6.01 -0.31 4.85e-9 Blood pressure (smoking interaction); LUSC cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg23788917 chr6:8435910 SLC35B3 0.49 7.22 0.37 3.45e-12 Motion sickness; LUSC cis rs2835872 0.965 rs73222309 chr21:39013686 C/T cg20424643 chr21:39039972 KCNJ6 0.42 6.42 0.33 4.57e-10 Electroencephalographic traits in alcoholism; LUSC cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.05 -0.36 1.02e-11 Colorectal cancer; LUSC cis rs4268898 0.717 rs3731626 chr2:24427864 G/A cg06627628 chr2:24431161 ITSN2 -0.87 -13.07 -0.58 7.95e-32 Asthma; LUSC trans rs7395662 0.864 rs10839201 chr11:48989417 A/G cg03929089 chr4:120376271 NA 0.43 5.95 0.31 6.85e-9 HDL cholesterol; LUSC cis rs7582720 1.000 rs115396314 chr2:203721314 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.22 16.64 0.67 1.02e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs61931739 0.500 rs10844862 chr12:34531965 A/T cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs6696846 0.765 rs3738155 chr1:205074424 C/T cg21545522 chr1:205238299 TMCC2 0.46 8.63 0.43 2.61e-16 Red blood cell count; LUSC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg18240062 chr17:79603768 NPLOC4 0.58 10.12 0.48 3.47e-21 Eye color traits; LUSC cis rs6539267 1.000 rs6539267 chr12:106785554 T/C cg00173435 chr12:106696525 TCP11L2 0.41 6.04 0.31 4.04e-9 Tourette syndrome; LUSC cis rs7582180 0.629 rs13010911 chr2:100953390 G/C cg12002119 chr2:101014098 CHST10 0.35 5.66 0.3 3.26e-8 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.629 rs12989897 chr2:100940998 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC trans rs62458065 0.513 rs7788809 chr7:32552622 T/A cg00845942 chr12:64062724 DPY19L2 -0.59 -7.41 -0.38 1.02e-12 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7615316 0.934 rs9855919 chr3:142234589 C/A cg16271453 chr3:142027066 XRN1 -0.4 -6.88 -0.35 3.04e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs1532331 0.833 rs10058350 chr5:43141644 T/C cg02477305 chr13:23993013 SACS 0.37 6.2 0.32 1.66e-9 Menarche (age at onset); LUSC cis rs3008870 0.583 rs17497947 chr1:67457199 G/T cg08660285 chr1:67390436 MIER1;WDR78 -0.94 -13.7 -0.6 3.26e-34 Lymphocyte percentage of white cells; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg00149659 chr3:10157352 C3orf10 1.0 14.8 0.63 1.89e-38 Alzheimer's disease; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg22638593 chr5:131593259 PDLIM4 -0.41 -5.84 -0.3 1.25e-8 Blood metabolite levels; LUSC cis rs2050392 0.762 rs306587 chr10:30722908 G/C cg18806716 chr10:30721971 MAP3K8 -0.48 -7.83 -0.39 6.36e-14 Inflammatory bowel disease; LUSC cis rs7267979 1.000 rs2482911 chr20:25395528 T/C cg08601574 chr20:25228251 PYGB -0.45 -6.89 -0.35 2.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg05283184 chr6:79620031 NA -0.54 -10.73 -0.51 2.83e-23 Intelligence (multi-trait analysis); LUSC cis rs877282 0.853 rs11595507 chr10:756703 C/T cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs3784262 1.000 rs4646640 chr15:58247563 C/G cg12031962 chr15:58353849 ALDH1A2 0.32 5.92 0.31 7.98e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg07741184 chr6:167504864 NA 0.43 7.57 0.38 3.58e-13 Primary biliary cholangitis; LUSC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg19622623 chr12:86230825 RASSF9 0.4 5.81 0.3 1.46e-8 Major depressive disorder; LUSC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg17158414 chr2:27665306 KRTCAP3 -0.34 -6.56 -0.34 2.09e-10 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05162137 chr1:146644430 PRKAB2 -0.41 -6.22 -0.32 1.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4631830 0.900 rs11006274 chr10:51540291 C/T cg20129853 chr10:51489980 NA 0.32 6.47 0.33 3.53e-10 Prostate-specific antigen levels; LUSC cis rs2839186 0.565 rs2839183 chr21:47687144 G/A cg12379764 chr21:47803548 PCNT 0.67 10.27 0.49 1.14e-21 Testicular germ cell tumor; LUSC cis rs12519773 1.000 rs12519773 chr5:92464416 A/G cg18783429 chr5:92414398 NA 0.27 5.96 0.31 6.5e-9 Migraine; LUSC cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.83 -0.54 3.32e-27 Chronic sinus infection; LUSC cis rs921968 0.643 rs2556385 chr2:219532905 G/A cg02176678 chr2:219576539 TTLL4 -0.58 -10.42 -0.5 3.41e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs2404602 0.735 rs2461870 chr15:76813920 T/G cg23625390 chr15:77176239 SCAPER -0.56 -8.86 -0.44 4.81e-17 Blood metabolite levels; LUSC cis rs11587682 0.760 rs36020363 chr1:150448666 C/G cg11822372 chr1:151115635 SEMA6C -0.43 -5.74 -0.3 2.12e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg18305652 chr10:134549665 INPP5A 0.44 6.68 0.34 9.79e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg06238570 chr21:40685208 BRWD1 -0.63 -10.81 -0.51 1.54e-23 Cognitive function; LUSC cis rs57590327 0.503 rs13062741 chr3:81887124 C/T cg07356753 chr3:81810745 GBE1 -0.65 -10.2 -0.49 1.9e-21 Extraversion; LUSC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg11764359 chr7:65958608 NA -0.53 -6.87 -0.35 3.07e-11 Aortic root size; LUSC cis rs79349575 0.715 rs11657238 chr17:46985634 A/G cg22482690 chr17:47019901 SNF8 0.34 6.13 0.32 2.49e-9 Type 2 diabetes; LUSC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg26597838 chr10:835615 NA 0.96 12.5 0.56 1.13e-29 Eosinophil percentage of granulocytes; LUSC cis rs7617773 0.832 rs6775114 chr3:48182620 G/C cg11946769 chr3:48343235 NME6 -0.62 -9.45 -0.46 6.24e-19 Coronary artery disease; LUSC cis rs2901656 1.000 rs6699095 chr1:172429245 T/C cg03748243 chr1:172413542 C1orf105;PIGC 0.29 5.9 0.31 9.11e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs17685 0.753 rs10264760 chr7:75749694 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.94 -0.4 3.06e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg14844989 chr11:31128820 NA -0.39 -6.03 -0.31 4.39e-9 Red blood cell count; LUSC cis rs7746199 0.736 rs10484399 chr6:27534528 A/G cg09904177 chr6:26538194 HMGN4 -0.72 -6.17 -0.32 1.98e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg26338869 chr17:61819248 STRADA 0.41 6.02 0.31 4.68e-9 Prudent dietary pattern; LUSC cis rs225245 0.782 rs321617 chr17:33915246 A/G cg05299278 chr17:33885742 SLFN14 0.31 6.82 0.35 4.37e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs981844 0.796 rs13140722 chr4:154712203 T/A cg14289246 chr4:154710475 SFRP2 -0.46 -5.92 -0.31 8.06e-9 Response to statins (LDL cholesterol change); LUSC cis rs210143 1 rs210143 chr6:33546930 T/C cg24505687 chr6:33548425 BAK1 0.45 6.52 0.34 2.6200000000000003e-10 Neutrophil percentage of granulocytes;B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy);Chronic lymphocytic leukemia; LUSC cis rs422249 0.512 rs174566 chr11:61592362 A/G cg19610905 chr11:61596333 FADS2 -0.53 -8.0 -0.4 2.03e-14 Trans fatty acid levels; LUSC cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg13126279 chr21:47581558 C21orf56 -0.39 -5.88 -0.31 9.83e-9 Testicular germ cell tumor; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.79 0.39 8.73e-14 Prudent dietary pattern; LUSC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg14019146 chr3:50243930 SLC38A3 -0.32 -7.1 -0.36 7.5e-12 Intelligence (multi-trait analysis); LUSC cis rs4654899 0.571 rs1888759 chr1:21065167 G/A cg01072550 chr1:21505969 NA -0.45 -6.76 -0.35 6.2e-11 Superior frontal gyrus grey matter volume; LUSC cis rs8179 0.553 rs42377 chr7:92243672 G/A cg15732164 chr7:92237376 CDK6 -0.42 -6.49 -0.33 3.06e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg13722127 chr7:150037890 RARRES2 0.38 5.72 0.3 2.39e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg11062466 chr8:58055876 NA 0.51 6.58 0.34 1.85e-10 Developmental language disorder (linguistic errors); LUSC cis rs1150668 0.796 rs2531832 chr6:28389222 G/A cg21251018 chr6:28226885 NKAPL 0.31 5.79 0.3 1.62e-8 Pubertal anthropometrics; LUSC cis rs11958404 0.932 rs7706111 chr5:157416053 C/T cg05962755 chr5:157440814 NA 0.48 6.19 0.32 1.72e-9 IgG glycosylation; LUSC cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg07741184 chr6:167504864 NA -0.39 -7.1 -0.36 7.35e-12 Crohn's disease; LUSC trans rs731565 1.000 rs731565 chr7:147406262 C/T cg12847240 chr6:10382088 NA -0.55 -6.1 -0.32 2.97e-9 Diabetic kidney disease; LUSC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -12.06 -0.55 4.59e-28 Type 2 diabetes; LUSC cis rs5769707 0.521 rs5769719 chr22:50062101 G/A cg05373962 chr22:49881684 NA -0.39 -8.25 -0.41 3.62e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg20701182 chr2:24300061 SF3B14 0.88 11.35 0.53 1.86e-25 Lymphocyte counts; LUSC cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.11 0.45 7.5e-18 Motion sickness; LUSC cis rs2404602 0.692 rs12904198 chr15:77146978 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.92 -0.35 2.38e-11 Blood metabolite levels; LUSC cis rs7124681 0.565 rs2904127 chr11:47817290 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.52 0.34 2.68e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg07507251 chr3:52567010 NT5DC2 0.33 6.4 0.33 5.34e-10 Bipolar disorder; LUSC cis rs9467773 1.000 rs1321480 chr6:26532742 A/G cg11502198 chr6:26597334 ABT1 0.59 9.25 0.45 2.85e-18 Intelligence (multi-trait analysis); LUSC cis rs1163251 0.837 rs517533 chr1:120229170 T/G cg19096424 chr1:120255104 PHGDH 0.45 6.18 0.32 1.85e-9 Blood metabolite levels; LUSC cis rs7089973 0.523 rs7090904 chr10:116775885 G/T cg23260525 chr10:116636907 FAM160B1 0.3 5.97 0.31 6.12e-9 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs8114671 0.562 rs2378292 chr20:33485178 T/C cg24642439 chr20:33292090 TP53INP2 0.45 6.5 0.34 2.88e-10 Height; LUSC cis rs2430307 0.518 rs67763033 chr7:76517677 A/G cg15770687 chr7:76625569 PMS2L11 0.85 8.87 0.44 4.64e-17 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs909341 0.818 rs67468102 chr20:62344883 G/C cg09650180 chr20:62225654 GMEB2 -0.44 -5.79 -0.3 1.62e-8 Atopic dermatitis; LUSC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg09365446 chr1:150670422 GOLPH3L 0.51 7.83 0.39 6.48e-14 Melanoma; LUSC cis rs6087990 0.735 rs2424907 chr20:31359819 C/T cg13636640 chr20:31349939 DNMT3B 0.9 18.29 0.71 2.9e-52 Ulcerative colitis; LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -7.85 -0.39 5.67e-14 Bipolar disorder and schizophrenia; LUSC cis rs1371867 0.875 rs1660320 chr8:101337579 A/C cg06002616 chr8:101225028 SPAG1 -0.4 -6.7 -0.34 8.89e-11 Atrioventricular conduction; LUSC cis rs55665837 1.000 rs7121171 chr11:14446420 A/G cg05501817 chr11:14380813 RRAS2 -0.4 -6.53 -0.34 2.46e-10 Vitamin D levels; LUSC cis rs2798269 0.966 rs2040059 chr13:22143100 C/G cg18095732 chr13:22033692 ZDHHC20 0.39 5.9 0.31 8.89e-9 PR segment; LUSC cis rs7917772 0.582 rs12779854 chr10:104358474 G/A cg05855489 chr10:104503620 C10orf26 0.49 7.52 0.38 4.99e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7582720 1.000 rs72926794 chr2:203827432 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs8072100 0.875 rs9635762 chr17:45648446 A/C cg04995722 chr7:26192034 NFE2L3 0.37 6.15 0.32 2.24e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2073300 0.609 rs17757442 chr20:23421101 A/G cg12062639 chr20:23401060 NAPB -0.97 -8.32 -0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs5997397 0.934 rs6005864 chr22:29157487 A/G cg02153584 chr22:29168773 CCDC117 -0.49 -7.69 -0.39 1.64e-13 Red cell distribution width; LUSC cis rs9311676 0.656 rs6445977 chr3:58379560 T/C cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC cis rs1153858 1.000 rs4775895 chr15:45617957 T/A cg26924012 chr15:45694286 SPATA5L1 1.13 19.82 0.74 2.46e-58 Homoarginine levels; LUSC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.4 -6.28 -0.33 1.04e-9 Total body bone mineral density; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10093594 chr1:206858754 MAPKAPK2 0.43 6.75 0.35 6.63e-11 Triglycerides; LUSC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11644478 chr21:40555479 PSMG1 0.95 18.99 0.72 4.85e-55 Cognitive function; LUSC cis rs7712401 0.601 rs35479600 chr5:122324470 G/T cg19077854 chr5:122220652 SNX24 -0.42 -9.14 -0.45 6.24e-18 Mean platelet volume; LUSC trans rs12210905 0.925 rs115182402 chr6:26980110 G/T cg11837749 chr1:55047332 ACOT11 0.55 5.96 0.31 6.41e-9 Hip circumference adjusted for BMI; LUSC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg06740227 chr12:86229804 RASSF9 0.45 7.18 0.37 4.43e-12 Major depressive disorder; LUSC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg02569458 chr12:86230093 RASSF9 0.48 7.7 0.39 1.6e-13 Major depressive disorder; LUSC cis rs10752881 0.875 rs10797825 chr1:183024581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 11.08 0.52 1.67e-24 Colorectal cancer; LUSC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.38e-21 Electroencephalogram traits; LUSC cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg05973401 chr12:123451056 ABCB9 0.51 6.44 0.33 4.24e-10 Neutrophil percentage of white cells; LUSC cis rs2404602 0.692 rs2137307 chr15:77149020 T/A cg26408565 chr15:76604113 ETFA -0.48 -7.64 -0.39 2.38e-13 Blood metabolite levels; LUSC cis rs3859192 0.561 rs9916158 chr17:38182229 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.69 12.47 0.56 1.49e-29 White blood cell count; LUSC cis rs1395 0.710 rs58965570 chr2:27481460 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.18 0.37 4.48e-12 Blood metabolite levels; LUSC cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.79 0.65 2.33e-42 Bladder cancer; LUSC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg02782426 chr3:40428986 ENTPD3 0.33 6.08 0.32 3.26e-9 Renal cell carcinoma; LUSC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg15212455 chr7:39170539 POU6F2 0.66 11.19 0.52 6.55e-25 IgG glycosylation; LUSC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs12545109 0.879 rs1975285 chr8:57358682 G/C cg09654669 chr8:57350985 NA -0.56 -7.48 -0.38 6.83e-13 Obesity-related traits; LUSC cis rs1113500 0.933 rs745795 chr1:108629345 C/T cg11967332 chr1:108735228 SLC25A24 0.38 5.76 0.3 1.92e-8 Growth-regulated protein alpha levels; LUSC cis rs826838 0.616 rs2200605 chr12:38624088 G/A cg13010199 chr12:38710504 ALG10B 0.47 7.09 0.36 8.21e-12 Heart rate; LUSC cis rs11190604 0.767 rs4919459 chr10:102200371 C/T cg07080220 chr10:102295463 HIF1AN 0.62 8.3 0.41 2.55e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7481584 0.624 rs449164 chr11:3053454 C/T cg25174290 chr11:3078921 CARS -0.41 -6.05 -0.31 3.94e-9 Calcium levels; LUSC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg19592336 chr6:28129416 ZNF389 0.49 6.46 0.33 3.7e-10 Depression; LUSC cis rs56399783 0.901 rs17132624 chr7:2778496 G/A cg19731401 chr7:2775893 GNA12 0.72 8.67 0.43 1.95e-16 Childhood ear infection; LUSC cis rs12681287 0.604 rs13279589 chr8:87477723 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.34e-12 Caudate activity during reward; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.48 7.33 0.37 1.8e-12 Renal function-related traits (BUN); LUSC cis rs7927771 0.524 rs10838775 chr11:47856382 C/G cg20307385 chr11:47447363 PSMC3 0.45 6.55 0.34 2.17e-10 Subjective well-being; LUSC cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg26384229 chr12:38710491 ALG10B 0.94 17.96 0.7 5.88e-51 Heart rate; LUSC cis rs7180079 0.620 rs7162324 chr15:64736287 A/G cg08069370 chr15:64387884 SNX1 0.56 6.25 0.32 1.25e-9 Monocyte count; LUSC cis rs2820315 0.867 rs2820321 chr1:201880296 G/C cg10061532 chr1:201886748 LMOD1 0.27 6.19 0.32 1.73e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg11578532 chr1:161008127 TSTD1 0.35 7.29 0.37 2.28e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs3862030 0.720 rs7342070 chr10:104223628 T/C cg05855489 chr10:104503620 C10orf26 0.51 7.73 0.39 1.29e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg22590775 chr19:49891494 CCDC155 0.57 7.55 0.38 4.1e-13 Multiple sclerosis; LUSC cis rs5769707 0.656 rs135878 chr22:50014369 T/A cg20744362 chr22:50050164 C22orf34 0.39 7.18 0.37 4.45e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg23711669 chr6:146136114 FBXO30 -0.83 -14.97 -0.63 3.88e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs7954584 0.504 rs10840633 chr12:122377511 A/T cg21171335 chr12:122356390 WDR66 0.64 9.4 0.46 9.22e-19 Mean corpuscular volume; LUSC cis rs11122272 0.735 rs2247124 chr1:231493687 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.67 -10.37 -0.49 4.88e-22 Hemoglobin concentration; LUSC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg20573242 chr4:122745356 CCNA2 0.45 6.88 0.35 2.97e-11 Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26591144 chr17:1532201 SLC43A2 -0.4 -5.98 -0.31 5.63e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg17845761 chr1:175162550 KIAA0040 0.32 6.02 0.31 4.5e-9 Alcohol dependence; LUSC cis rs56283067 0.887 rs12200892 chr6:44768925 T/C cg18551225 chr6:44695536 NA -0.48 -7.65 -0.39 2.22e-13 Total body bone mineral density; LUSC cis rs13385 0.769 rs7737342 chr5:139611011 A/T cg26211634 chr5:139558579 C5orf32 0.45 6.99 0.36 1.47e-11 Atrial fibrillation; LUSC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg18252515 chr7:66147081 NA -1.22 -14.04 -0.61 1.61e-35 Diabetic kidney disease; LUSC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg04450456 chr4:17643702 FAM184B 0.35 5.81 0.3 1.47e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg14092988 chr3:52407081 DNAH1 0.3 5.93 0.31 7.54e-9 Bipolar disorder; LUSC cis rs11098499 0.863 rs10019674 chr4:120443489 C/T cg09307838 chr4:120376055 NA -0.74 -10.38 -0.49 4.63e-22 Corneal astigmatism; LUSC cis rs17828380 1.000 rs8043419 chr15:63539622 C/T cg05507819 chr15:63340323 TPM1 -0.71 -6.13 -0.32 2.54e-9 Social communication problems; LUSC cis rs748404 0.631 rs6493084 chr15:43647627 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.29 0.33 1.01e-9 Lung cancer; LUSC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.5 0.59 1.96e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg14895029 chr7:2775587 GNA12 -0.4 -5.95 -0.31 6.94e-9 Height; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg21782813 chr7:2030301 MAD1L1 0.52 8.66 0.43 2.07e-16 Bipolar disorder and schizophrenia; LUSC cis rs17253792 0.822 rs113692713 chr14:56087424 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs2688608 0.592 rs2306328 chr10:75579510 C/T cg17411546 chr10:75410026 SYNPO2L -0.51 -7.59 -0.38 3.16e-13 Inflammatory bowel disease; LUSC cis rs12493885 0.818 rs62276828 chr3:153775941 C/T cg17054900 chr3:154042577 DHX36 -0.72 -7.09 -0.36 8.25e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg23719950 chr11:63933701 MACROD1 -0.61 -7.94 -0.4 3.13e-14 Mean platelet volume; LUSC cis rs3106136 0.934 rs35995707 chr4:95167150 C/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.02 -0.31 4.68e-9 Capecitabine sensitivity; LUSC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg22618164 chr12:122356400 WDR66 0.65 9.54 0.46 3.04e-19 Mean corpuscular volume; LUSC cis rs7615952 0.611 rs35321002 chr3:125612065 G/C cg05084668 chr3:125655381 ALG1L -0.83 -11.86 -0.54 2.53e-27 Blood pressure (smoking interaction); LUSC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg13393036 chr8:95962371 TP53INP1 -0.34 -6.43 -0.33 4.51e-10 Type 2 diabetes; LUSC cis rs908922 0.676 rs7550769 chr1:152531213 G/A cg20991723 chr1:152506922 NA 0.49 9.19 0.45 4.2e-18 Hair morphology; LUSC cis rs780096 0.526 rs11682621 chr2:27749669 G/A cg27432699 chr2:27873401 GPN1 -0.65 -9.83 -0.47 3.32e-20 Total body bone mineral density; LUSC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg13683864 chr3:40499215 RPL14 -1.13 -20.96 -0.75 7.35e-63 Renal cell carcinoma; LUSC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg26384229 chr12:38710491 ALG10B -0.82 -14.08 -0.61 1.14e-35 Bladder cancer; LUSC cis rs9463078 0.753 rs636845 chr6:44935341 C/T cg25276700 chr6:44698697 NA -0.29 -6.04 -0.31 4.17e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg21672276 chr3:44754072 ZNF502 -0.38 -6.05 -0.31 3.8e-9 Depressive symptoms; LUSC cis rs672059 1.000 rs638781 chr1:183157358 T/G ch.1.3577855R chr1:183094577 LAMC1 0.54 7.99 0.4 2.15e-14 Hypertriglyceridemia; LUSC cis rs10089 1.000 rs3805607 chr5:127477418 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.88 12.42 0.56 2.19e-29 Ileal carcinoids; LUSC cis rs7072216 0.763 rs7910247 chr10:100172252 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg18876405 chr7:65276391 NA -0.55 -8.76 -0.43 9.78e-17 Aortic root size; LUSC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.46 8.83 0.43 6.23e-17 Monocyte percentage of white cells; LUSC cis rs2346177 0.846 rs62138876 chr2:46650672 C/A cg02822958 chr2:46747628 ATP6V1E2 0.39 6.73 0.35 7.31e-11 HDL cholesterol; LUSC cis rs12519773 0.526 rs4285204 chr5:92528272 C/T cg18783429 chr5:92414398 NA 0.34 7.19 0.37 4.38e-12 Migraine; LUSC cis rs1003719 0.715 rs6517405 chr21:38560334 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.41 -0.49 3.71e-22 Eye color traits; LUSC cis rs12594515 1.000 rs7173144 chr15:45991196 A/G cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg23262073 chr20:60523788 NA -0.64 -9.21 -0.45 3.59e-18 Obesity-related traits; LUSC cis rs7100689 0.646 rs1340384 chr10:82088702 T/A cg00277334 chr10:82204260 NA -0.58 -8.71 -0.43 1.47e-16 Post bronchodilator FEV1; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.47 6.23 0.32 1.38e-9 Renal function-related traits (BUN); LUSC cis rs12210905 0.925 rs115182402 chr6:26980110 G/T cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.98 -0.31 5.84e-9 Hip circumference adjusted for BMI; LUSC cis rs8060686 0.641 rs28508024 chr16:68126606 T/C cg04539111 chr16:67997858 SLC12A4 -0.42 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs3857536 0.740 rs9354390 chr6:66890162 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.43 5.96 0.31 6.27e-9 Blood trace element (Cu levels); LUSC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg05425664 chr17:57184151 TRIM37 0.58 9.02 0.44 1.52e-17 Intelligence (multi-trait analysis); LUSC cis rs7119 0.700 rs7497168 chr15:77886231 A/C cg27398640 chr15:77910606 LINGO1 0.37 8.53 0.42 5.04e-16 Type 2 diabetes; LUSC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg06656553 chr16:89960601 TCF25 -0.65 -5.7 -0.3 2.63e-8 Skin colour saturation; LUSC cis rs12579753 0.879 rs1922552 chr12:82158093 G/T cg07988820 chr12:82153109 PPFIA2 -0.45 -6.68 -0.34 9.94e-11 Resting heart rate; LUSC cis rs17001868 0.568 rs9611329 chr22:40792038 G/T cg07138101 chr22:40742427 ADSL 0.61 7.5 0.38 5.72e-13 Mammographic density (dense area); LUSC cis rs7617480 0.587 rs9311431 chr3:48848787 T/A cg21141812 chr3:48556323 PFKFB4 0.33 5.7 0.3 2.64e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs4363385 0.720 rs1611755 chr1:152956420 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.47e-13 Inflammatory skin disease; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg18765753 chr7:1198926 ZFAND2A -0.4 -7.42 -0.38 1e-12 Longevity;Endometriosis; LUSC cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 10.41 0.5 3.59e-22 Hip circumference adjusted for BMI; LUSC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg00310523 chr12:86230176 RASSF9 0.47 8.62 0.43 2.74e-16 Major depressive disorder; LUSC cis rs422249 0.512 rs174554 chr11:61579463 A/G cg19610905 chr11:61596333 FADS2 -0.55 -8.26 -0.41 3.54e-15 Trans fatty acid levels; LUSC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg08847533 chr14:75593920 NEK9 0.86 16.21 0.66 5.26e-44 Height; LUSC cis rs72781680 0.821 rs17045981 chr2:24109316 A/G cg08917208 chr2:24149416 ATAD2B 0.58 6.34 0.33 7.44e-10 Lymphocyte counts; LUSC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg10523679 chr1:76189770 ACADM -0.85 -13.84 -0.6 9.62e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg27094323 chr7:1216898 NA -0.44 -7.51 -0.38 5.38e-13 Longevity;Endometriosis; LUSC cis rs3806843 0.966 rs10060640 chr5:140211226 G/A cg03975922 chr5:140080575 ZMAT2 0.32 5.64 0.3 3.55e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg00864171 chr11:67383662 NA 0.35 6.28 0.32 1.05e-9 Mean corpuscular volume; LUSC cis rs7223966 1.000 rs8075521 chr17:61804954 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.92 0.35 2.31e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg24642439 chr20:33292090 TP53INP2 0.49 7.34 0.37 1.62e-12 Glomerular filtration rate (creatinine); LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg27170947 chr2:26402098 FAM59B 0.72 10.79 0.51 1.8e-23 Gut microbiome composition (summer); LUSC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg23711669 chr6:146136114 FBXO30 -0.91 -17.35 -0.69 1.61e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs2976388 0.669 rs1836633 chr8:143774592 G/A cg17252645 chr8:143867129 LY6D 0.39 6.74 0.35 6.97e-11 Urinary tract infection frequency; LUSC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg04369109 chr6:150039330 LATS1 -0.57 -8.31 -0.41 2.46e-15 Lung cancer; LUSC cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg07092213 chr7:1199455 ZFAND2A -0.54 -8.49 -0.42 6.84e-16 Longevity;Endometriosis; LUSC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.69 10.4 0.49 4.09e-22 Cognitive test performance; LUSC cis rs6977660 1.000 rs57916046 chr7:19800542 T/C cg07541023 chr7:19748670 TWISTNB 0.57 6.22 0.32 1.5e-9 Thyroid stimulating hormone; LUSC cis rs1949733 0.523 rs56053534 chr4:8542876 G/A cg11789530 chr4:8429930 ACOX3 -0.4 -5.86 -0.31 1.13e-8 Response to antineoplastic agents; LUSC cis rs4144743 1.000 rs4144746 chr17:45323355 C/G cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs12908161 0.853 rs11633788 chr15:85305142 T/A cg12863693 chr15:85201151 NMB 0.34 7.52 0.38 5.14e-13 Schizophrenia; LUSC cis rs9399135 0.967 rs9376075 chr6:135296963 A/G cg22676075 chr6:135203613 NA 0.47 7.33 0.37 1.72e-12 Red blood cell count; LUSC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg13319975 chr6:146136371 FBXO30 0.51 7.7 0.39 1.51e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg01503450 chr10:980765 NA -0.4 -5.81 -0.3 1.45e-8 Eosinophil percentage of granulocytes; LUSC cis rs7674212 0.507 rs223413 chr4:103732866 A/G cg16532752 chr4:104119610 CENPE 0.41 5.88 0.31 9.87e-9 Type 2 diabetes; LUSC cis rs9325144 0.505 rs826893 chr12:39100536 A/G cg13010199 chr12:38710504 ALG10B -0.61 -9.96 -0.48 1.27e-20 Morning vs. evening chronotype; LUSC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg00701064 chr4:6280414 WFS1 0.58 14.61 0.62 9.98e-38 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg06873352 chr17:61820015 STRADA 0.7 12.15 0.55 2.24e-28 Prudent dietary pattern; LUSC cis rs965513 1.000 rs10983761 chr9:100553957 A/C cg13688889 chr9:100608707 NA -0.54 -8.16 -0.41 6.68e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs7712401 0.580 rs10066632 chr5:122364683 C/A cg19077854 chr5:122220652 SNX24 0.38 7.95 0.4 2.97e-14 Mean platelet volume; LUSC cis rs71403859 0.614 rs12447033 chr16:71583655 G/T cg08717414 chr16:71523259 ZNF19 -0.75 -8.91 -0.44 3.28e-17 Post bronchodilator FEV1; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg14893161 chr1:205819251 PM20D1 0.93 18.32 0.71 2.21e-52 Menarche (age at onset); LUSC cis rs7605378 1.000 rs796363 chr2:200693668 T/C cg17644776 chr2:200775616 C2orf69 0.37 6.06 0.31 3.68e-9 Osteoporosis; LUSC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg15448220 chr1:150897856 SETDB1 0.41 5.89 0.31 9.46e-9 Melanoma; LUSC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.88 0.48 2.23e-20 Personality dimensions; LUSC cis rs62458065 0.850 rs6462362 chr7:32464733 C/T cg20159608 chr7:32802032 NA -0.61 -7.27 -0.37 2.54e-12 Metabolite levels (HVA/MHPG ratio); LUSC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg04455712 chr21:45112962 RRP1B 0.46 8.81 0.43 6.9e-17 Mean corpuscular volume; LUSC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.8 -0.35 4.82e-11 Alzheimer's disease (late onset); LUSC cis rs6545883 0.894 rs12997538 chr2:61564249 A/C cg15711740 chr2:61764176 XPO1 0.48 7.4 0.38 1.09e-12 Tuberculosis; LUSC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg01579765 chr21:45077557 HSF2BP -0.56 -11.85 -0.54 2.82e-27 Mean corpuscular volume; LUSC cis rs7267979 0.966 rs2261794 chr20:25263062 T/G cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.56e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7944584 0.588 rs2697923 chr11:47363215 G/T cg20307385 chr11:47447363 PSMC3 -0.71 -11.03 -0.52 2.55e-24 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11644478 chr21:40555479 PSMG1 -0.66 -10.3 -0.49 8.65e-22 Menarche (age at onset); LUSC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg07777115 chr5:623756 CEP72 -0.47 -5.88 -0.31 1.02e-8 Obesity-related traits; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg14893161 chr1:205819251 PM20D1 -0.8 -16.05 -0.66 2.34e-43 Monocyte percentage of white cells; LUSC cis rs981844 0.857 rs62325142 chr4:154717790 A/G cg14289246 chr4:154710475 SFRP2 0.49 6.21 0.32 1.6e-9 Response to statins (LDL cholesterol change); LUSC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg25072359 chr17:41440525 NA 0.58 8.24 0.41 3.85e-15 Menopause (age at onset); LUSC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg11645453 chr3:52864694 ITIH4 0.31 7.25 0.37 2.85e-12 Bipolar disorder; LUSC trans rs629535 0.734 rs659430 chr8:70009988 A/G cg21567404 chr3:27674614 NA 0.79 13.04 0.58 1.04e-31 Dupuytren's disease; LUSC cis rs782590 0.935 rs2627776 chr2:55873301 T/A cg18811423 chr2:55921094 PNPT1 0.84 14.7 0.63 4.55e-38 Metabolic syndrome; LUSC cis rs72781680 1.000 rs12616899 chr2:24165235 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs10740039 0.883 rs10994455 chr10:62405347 G/T cg18175470 chr10:62150864 ANK3 -0.46 -6.86 -0.35 3.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6558174 1.000 rs6558174 chr8:22492129 A/G cg03733263 chr8:22462867 KIAA1967 0.47 6.15 0.32 2.21e-9 Breast cancer; LUSC cis rs9462027 0.675 rs13206387 chr6:34696792 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.31 -5.65 -0.3 3.46e-8 Systemic lupus erythematosus; LUSC cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg11189052 chr15:85197271 WDR73 0.53 5.97 0.31 6.13e-9 Schizophrenia; LUSC cis rs73206853 0.640 rs35026231 chr12:110832125 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs12477438 0.765 rs12612688 chr2:99613091 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.58 -0.5 9.6e-23 Chronic sinus infection; LUSC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg13939156 chr17:80058883 NA 0.33 6.42 0.33 4.59e-10 Life satisfaction; LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC trans rs961253 0.556 rs6076983 chr20:6331376 C/T cg21095983 chr6:86352623 SYNCRIP 0.45 6.81 0.35 4.68e-11 Colorectal cancer; LUSC trans rs61931739 0.500 rs6488213 chr12:34393319 C/T cg13010199 chr12:38710504 ALG10B 0.58 9.23 0.45 3.24e-18 Morning vs. evening chronotype; LUSC cis rs8038465 0.592 rs899981 chr15:73935329 G/A cg15420318 chr15:73925796 NPTN 0.57 9.73 0.47 7.53e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs74181299 0.890 rs2540950 chr2:65279223 C/T cg05010058 chr2:65284262 CEP68 0.31 6.11 0.32 2.75e-9 Pulse pressure; LUSC cis rs62027291 0.561 rs2469196 chr15:77266688 A/G cg26408565 chr15:76604113 ETFA -0.45 -6.12 -0.32 2.69e-9 Plateletcrit; LUSC cis rs7264396 0.563 rs2425130 chr20:34335059 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.35 -0.42 1.87e-15 Total cholesterol levels; LUSC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.36 0.42 1.73e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.680 rs11777459 chr8:58044241 A/T cg08219700 chr8:58056026 NA 0.49 6.04 0.31 4.12e-9 Developmental language disorder (linguistic errors); LUSC cis rs11190604 1.000 rs2295776 chr10:102295629 G/T cg16342193 chr10:102329863 NA -0.36 -6.56 -0.34 2.08e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11051970 0.879 rs2651362 chr12:32587851 G/C cg02745156 chr12:32552066 NA 0.43 7.29 0.37 2.29e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg13798780 chr7:105162888 PUS7 0.56 6.04 0.31 4.04e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6736175 1.000 rs12463658 chr2:191965344 A/C cg11255154 chr2:191879104 STAT1 0.35 5.68 0.3 2.9e-8 Systemic lupus erythematosus; LUSC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg10523679 chr1:76189770 ACADM 0.89 13.88 0.6 6.58e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9549367 0.789 rs9549708 chr13:113891887 A/G cg18105134 chr13:113819100 PROZ -0.67 -9.4 -0.46 8.62e-19 Platelet distribution width; LUSC cis rs10771431 0.782 rs10771415 chr12:9358223 C/T cg00504896 chr12:9437009 LOC642846 -0.4 -6.02 -0.31 4.69e-9 Breast size; LUSC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg18240062 chr17:79603768 NPLOC4 0.58 10.1 0.48 4.09e-21 Eye color traits; LUSC trans rs3960554 0.569 rs10464565 chr7:75869526 T/G cg19862616 chr7:65841803 NCRNA00174 0.64 7.88 0.4 4.65e-14 Eotaxin levels; LUSC trans rs12310956 0.532 rs11608842 chr12:33951121 C/T cg13010199 chr12:38710504 ALG10B 0.47 7.17 0.37 4.89e-12 Morning vs. evening chronotype; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg14820908 chr5:178986412 RUFY1 0.68 13.01 0.58 1.36e-31 Lung cancer; LUSC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg18681998 chr4:17616180 MED28 0.89 17.39 0.69 1.05e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11822910 0.737 rs2729389 chr11:57211646 A/G cg00522883 chr11:57194120 SLC43A3 -0.4 -6.62 -0.34 1.4e-10 Platelet distribution width; LUSC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg17376030 chr22:41985996 PMM1 -0.47 -5.84 -0.3 1.25e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg09537434 chr19:41945824 ATP5SL 0.54 7.37 0.37 1.39e-12 Colorectal cancer; LUSC cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg19875535 chr5:140030758 IK -0.53 -8.75 -0.43 1.07e-16 Depressive symptoms (multi-trait analysis); LUSC trans rs72674100 1.000 rs28835944 chr4:97962356 A/G cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2806561 0.704 rs664301 chr1:23522522 C/T cg12483005 chr1:23474871 LUZP1 0.45 6.92 0.35 2.28e-11 Height; LUSC trans rs1493916 1.000 rs11081827 chr18:31390228 C/A cg15819921 chr19:927150 ARID3A -0.46 -6.74 -0.35 7.14e-11 Life satisfaction; LUSC cis rs13242816 1.000 rs4292624 chr7:116102724 A/C cg16553024 chr7:116138462 CAV2 -0.53 -5.81 -0.3 1.46e-8 P wave duration; LUSC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg04166393 chr7:2884313 GNA12 0.46 5.98 0.31 5.84e-9 Height; LUSC cis rs9427116 0.677 rs9426831 chr1:154609657 A/T cg17218026 chr1:154582156 ADAR -0.55 -9.77 -0.47 5.39e-20 Blood protein levels; LUSC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg09455208 chr3:40491958 NA 0.59 10.2 0.49 1.87e-21 Renal cell carcinoma; LUSC cis rs7914558 1.000 rs7899084 chr10:104872547 A/T cg04362960 chr10:104952993 NT5C2 0.6 9.53 0.46 3.28e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg00631329 chr6:26305371 NA 0.33 5.71 0.3 2.52e-8 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.844 rs8184820 chr20:25250577 C/T cg08601574 chr20:25228251 PYGB -0.54 -8.61 -0.43 2.95e-16 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.58 0.5 9.15e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg13531842 chr10:38383804 ZNF37A -0.46 -7.19 -0.37 4.37e-12 Extrinsic epigenetic age acceleration; LUSC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg24154853 chr7:158122151 PTPRN2 -0.42 -8.15 -0.41 7.64e-15 Calcium levels; LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2481665 0.904 rs2481677 chr1:62632571 G/A cg18591186 chr1:62594603 INADL -0.46 -7.29 -0.37 2.24e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3859192 0.577 rs2227333 chr17:38174167 C/G cg17467752 chr17:38218738 THRA -0.53 -7.54 -0.38 4.42e-13 White blood cell count; LUSC cis rs12618769 0.625 rs72819984 chr2:99044762 G/C cg10123293 chr2:99228465 UNC50 0.45 7.64 0.39 2.31e-13 Bipolar disorder; LUSC cis rs9324022 0.858 rs1004573 chr14:101178235 G/C cg18089426 chr14:101175970 NA 0.46 5.65 0.3 3.45e-8 Plateletcrit; LUSC cis rs1670533 1.000 rs651017 chr4:1091062 A/G cg02018176 chr4:1364513 KIAA1530 0.41 5.87 0.31 1.03e-8 Recombination rate (females); LUSC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.22 0.32 1.45e-9 Schizophrenia; LUSC trans rs6030 1.000 rs2157581 chr1:169499190 A/G cg16792071 chr10:134842795 NA 0.28 6.04 0.31 4.17e-9 Uric acid levels; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.3 0.41 2.67e-15 Prudent dietary pattern; LUSC cis rs9457247 1.000 rs422094 chr6:167397033 C/G cg23791538 chr6:167370224 RNASET2 -0.41 -6.73 -0.35 7.32e-11 Crohn's disease; LUSC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 3.96e-11 Melanoma; LUSC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg10523679 chr1:76189770 ACADM -0.81 -11.1 -0.52 1.44e-24 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs9401746 0.564 rs578658 chr6:124785562 A/G cg16857858 chr7:27213984 HOXA10 0.51 6.29 0.33 9.92e-10 Bone mineral density (Ward's triangle area); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg26967579 chr5:65893440 MAST4 0.41 5.95 0.31 6.9e-9 Mosquito bite size; LUSC cis rs4713675 0.565 rs3818524 chr6:33660695 G/C cg14003231 chr6:33640908 ITPR3 0.31 5.94 0.31 7.14e-9 Plateletcrit; LUSC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg05340658 chr4:99064831 C4orf37 0.68 11.63 0.54 1.78e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs12760731 0.623 rs3791026 chr1:178343890 G/A cg00404053 chr1:178313656 RASAL2 0.48 5.82 0.3 1.38e-8 Obesity-related traits; LUSC cis rs929354 0.742 rs2006844 chr7:157002851 G/A cg05182265 chr7:156933206 UBE3C -0.6 -9.69 -0.47 9.72e-20 Body mass index; LUSC cis rs7772486 0.806 rs2247317 chr6:146217570 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -7.24 -0.37 3.19e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg07596845 chr6:82957841 IBTK 0.48 6.52 0.34 2.67e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs12545109 0.800 rs1960725 chr8:57411807 C/T cg09654669 chr8:57350985 NA -0.58 -7.84 -0.39 5.98e-14 Obesity-related traits; LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg11645453 chr3:52864694 ITIH4 0.33 7.24 0.37 3.11e-12 Bipolar disorder; LUSC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg10909506 chr17:38081995 ORMDL3 0.34 6.03 0.31 4.44e-9 Self-reported allergy; LUSC cis rs9309473 0.554 rs4330127 chr2:73581320 A/T cg20560298 chr2:73613845 ALMS1 -0.55 -8.1 -0.41 1.05e-14 Metabolite levels; LUSC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg03351412 chr1:154909251 PMVK 0.52 8.06 0.4 1.33e-14 Prostate cancer; LUSC cis rs11122272 0.677 rs2808615 chr1:231550171 G/A cg06096015 chr1:231504339 EGLN1 -0.53 -9.18 -0.45 4.66e-18 Hemoglobin concentration; LUSC cis rs77741769 0.571 rs11065283 chr12:121266453 A/G cg02419362 chr12:121203948 SPPL3 0.46 8.41 0.42 1.24e-15 Mean corpuscular volume; LUSC cis rs709400 0.663 rs62007681 chr14:103884651 G/A cg24130564 chr14:104152367 KLC1 -0.45 -6.21 -0.32 1.54e-9 Body mass index; LUSC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg06108461 chr20:60628389 TAF4 0.96 15.12 0.64 1.05e-39 Body mass index; LUSC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg09655341 chr17:79618100 PDE6G -0.29 -6.77 -0.35 5.94e-11 Eye color traits; LUSC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg06634786 chr22:41940651 POLR3H 0.53 6.18 0.32 1.82e-9 Vitiligo; LUSC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg17211192 chr8:82754475 SNX16 -0.64 -9.11 -0.45 7.56e-18 Diastolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13626842 chr6:3157721 TUBB2A -0.41 -6.01 -0.31 4.77e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10191773 0.589 rs72831641 chr2:112955815 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.58 -6.83 -0.35 4.06e-11 Yeast infection; LUSC cis rs7119 0.604 rs2271398 chr15:77907784 G/A cg27398640 chr15:77910606 LINGO1 0.38 8.89 0.44 3.98e-17 Type 2 diabetes; LUSC cis rs7799006 0.929 rs35629140 chr7:2257171 G/C cg12823233 chr7:2316876 SNX8 -0.38 -6.38 -0.33 5.87e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg01579765 chr21:45077557 HSF2BP -0.54 -11.24 -0.52 4.6e-25 Mean corpuscular volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg26151531 chr22:19842652 GNB1L;C22orf29 0.44 6.68 0.34 1.01e-10 Triglycerides; LUSC cis rs2274273 0.686 rs57033289 chr14:55623317 C/A cg04306507 chr14:55594613 LGALS3 0.48 9.7 0.47 9.24e-20 Protein biomarker; LUSC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg05729581 chr11:3078854 CARS 0.53 8.0 0.4 2.11e-14 Longevity; LUSC cis rs9392556 0.829 rs619873 chr6:4107455 A/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.39 -6.74 -0.35 6.76e-11 Blood metabolite levels; LUSC cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.36 0.56 3.77e-29 Colorectal cancer; LUSC cis rs9486719 0.749 rs1009596 chr6:96843688 A/G cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs1044826 0.692 rs184155 chr3:139229772 G/A cg00490450 chr3:139108681 COPB2 -0.46 -7.08 -0.36 8.77e-12 Obesity-related traits; LUSC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg17264618 chr3:40429014 ENTPD3 0.34 7.28 0.37 2.36e-12 Renal cell carcinoma; LUSC trans rs9329221 0.686 rs35840352 chr8:10239807 A/G cg15556689 chr8:8085844 FLJ10661 0.63 9.08 0.44 9.83e-18 Neuroticism; LUSC cis rs2637266 0.626 rs2583069 chr10:78546775 T/C cg18941641 chr10:78392320 NA 0.37 6.84 0.35 3.77e-11 Pulmonary function; LUSC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg23283495 chr1:209979779 IRF6 0.63 7.76 0.39 1.04e-13 Cleft lip with or without cleft palate; LUSC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg23093090 chr10:104574429 C10orf26 -0.39 -7.35 -0.37 1.51e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg02574844 chr11:5959923 NA -0.4 -6.06 -0.31 3.73e-9 DNA methylation (variation); LUSC cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg05283184 chr6:79620031 NA -0.57 -12.03 -0.55 6.25e-28 Intelligence (multi-trait analysis); LUSC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg09796270 chr17:17721594 SREBF1 0.4 7.12 0.36 6.49e-12 Total body bone mineral density; LUSC cis rs6967385 0.560 rs55794302 chr7:12351495 C/A cg10578991 chr7:12443926 VWDE 0.39 5.73 0.3 2.23e-8 Response to taxane treatment (placlitaxel); LUSC cis rs7520050 0.933 rs12045165 chr1:46256022 C/A cg24296786 chr1:45957014 TESK2 0.41 5.73 0.3 2.2e-8 Red blood cell count;Reticulocyte count; LUSC cis rs1670533 0.932 rs9992925 chr4:1050909 A/T cg02018176 chr4:1364513 KIAA1530 0.46 6.44 0.33 4.26e-10 Recombination rate (females); LUSC cis rs1322512 1.000 rs2800626 chr6:153006340 T/A cg27316956 chr6:152958899 SYNE1 0.34 5.98 0.31 5.72e-9 Tonometry; LUSC cis rs12477438 0.765 rs17708262 chr2:99696313 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -7.91 -0.4 3.79e-14 Chronic sinus infection; LUSC cis rs7180079 1.000 rs62024572 chr15:64499045 C/G cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs9790314 0.875 rs7615592 chr3:160981548 A/C cg04691961 chr3:161091175 C3orf57 -0.35 -5.95 -0.31 6.76e-9 Morning vs. evening chronotype; LUSC cis rs7011049 0.908 rs11986701 chr8:53833480 G/T cg26025543 chr8:53854495 NA 0.51 6.28 0.32 1.05e-9 Systolic blood pressure; LUSC cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs6964587 1.000 rs2301559 chr7:91746727 T/C cg01689657 chr7:91764605 CYP51A1 0.34 6.19 0.32 1.79e-9 Breast cancer; LUSC cis rs983392 0.680 rs56357056 chr11:59986817 A/G cg24026212 chr11:59952134 MS4A6A -0.35 -6.11 -0.32 2.75e-9 Alzheimer's disease (late onset); LUSC trans rs853679 0.607 rs72854513 chr6:28265954 A/T cg01620082 chr3:125678407 NA -0.82 -7.72 -0.39 1.35e-13 Depression; LUSC trans rs453301 0.571 rs330054 chr8:9088291 G/A cg27411982 chr8:10470053 RP1L1 -0.39 -6.09 -0.32 3.1e-9 Joint mobility (Beighton score); LUSC cis rs9457247 0.565 rs12178491 chr6:167512474 C/T cg06454157 chr6:167490870 NA -0.26 -5.88 -0.31 9.83e-9 Crohn's disease; LUSC cis rs8114671 0.933 rs6087683 chr20:33774444 C/T cg07148914 chr20:33460835 GGT7 0.46 6.84 0.35 3.87e-11 Height; LUSC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg21545522 chr1:205238299 TMCC2 0.49 9.2 0.45 3.93e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs8014204 0.836 rs8021280 chr14:75290018 C/G cg06637938 chr14:75390232 RPS6KL1 0.65 11.0 0.52 3.23e-24 Caffeine consumption; LUSC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg15704280 chr7:45808275 SEPT13 0.96 14.47 0.62 3.47e-37 Height; LUSC cis rs8114671 0.562 rs4911164 chr20:33479488 G/C cg07148914 chr20:33460835 GGT7 0.56 8.51 0.42 5.93e-16 Height; LUSC cis rs559928 1.000 rs72926050 chr11:64143574 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 6.79 0.35 5.13e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9341835 0.518 rs9350929 chr6:64175668 A/G cg03326410 chr6:64151739 NA -0.37 -5.95 -0.31 6.9e-9 Schizophrenia; LUSC trans rs2048656 0.535 rs2014514 chr8:9647196 A/T cg08975724 chr8:8085496 FLJ10661 0.45 6.59 0.34 1.75e-10 Schizophrenia; LUSC trans rs11098499 0.863 rs11933966 chr4:120476715 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs12220238 1.000 rs10824075 chr10:75880254 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.64 7.69 0.39 1.65e-13 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7246657 0.509 rs10426093 chr19:37615629 G/A cg23950597 chr19:37808831 NA -0.54 -5.86 -0.31 1.11e-8 Coronary artery calcification; LUSC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg27532560 chr4:187881888 NA 0.39 6.38 0.33 5.76e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs244731 0.959 rs4976677 chr5:176629546 G/A cg16006841 chr5:176797999 RGS14 -0.67 -9.66 -0.47 1.26e-19 Urate levels in lean individuals; LUSC cis rs6733011 0.628 rs6713991 chr2:99464384 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.45 -6.38 -0.33 5.77e-10 Bipolar disorder; LUSC cis rs950169 0.840 rs12905223 chr15:85114268 T/C cg17507749 chr15:85114479 UBE2QP1 0.71 9.44 0.46 6.7e-19 Schizophrenia; LUSC cis rs1560104 0.675 rs9927256 chr16:12705015 A/G cg02946846 chr16:12632861 SNX29 0.32 5.9 0.31 8.75e-9 Obesity-related traits; LUSC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg02569458 chr12:86230093 RASSF9 0.58 9.54 0.46 3.13e-19 Major depressive disorder; LUSC cis rs478304 0.654 rs12289836 chr11:65436888 C/T cg05805236 chr11:65401703 PCNXL3 0.66 10.81 0.51 1.47e-23 Acne (severe); LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg16325326 chr1:53192061 ZYG11B 0.81 13.96 0.61 3.24e-35 Monocyte count; LUSC cis rs10911232 0.507 rs10797829 chr1:183033228 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.7 -10.83 -0.51 1.31e-23 Hypertriglyceridemia; LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14240098 chr7:50518052 FIGNL1 -0.4 -6.15 -0.32 2.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6543140 0.964 rs4851010 chr2:103056127 A/T cg09003973 chr2:102972529 NA -0.54 -6.93 -0.35 2.13e-11 Blood protein levels; LUSC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg07636037 chr3:49044803 WDR6 1.03 18.02 0.7 3.34e-51 Parkinson's disease; LUSC cis rs9581857 0.547 rs75085794 chr13:28095944 A/C cg22138327 chr13:27999177 GTF3A 0.7 7.18 0.37 4.58e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.53 0.38 4.65e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11122272 0.735 rs11122279 chr1:231519804 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.76 -0.47 5.93e-20 Hemoglobin concentration; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg01577475 chr2:114033581 PAX8;LOC440839 -0.29 -7.43 -0.38 8.95e-13 Lymphocyte counts; LUSC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg26335602 chr6:28129616 ZNF389 0.45 6.03 0.31 4.24e-9 Parkinson's disease; LUSC cis rs4792901 0.759 rs3179927 chr17:41601911 A/G cg22562494 chr17:41607896 ETV4 -0.31 -5.95 -0.31 6.72e-9 Dupuytren's disease; LUSC cis rs4845459 0.967 rs6701307 chr1:152590444 G/A cg08895932 chr1:152778580 LCE1C -0.36 -6.26 -0.32 1.17e-9 Psoriasis; LUSC cis rs7582180 0.629 rs11693471 chr2:100948062 G/A cg12002119 chr2:101014098 CHST10 0.35 5.8 0.3 1.53e-8 Intelligence (multi-trait analysis); LUSC cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.45 -0.42 9.25e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12908161 1.000 rs11632465 chr15:85282045 A/T cg17173187 chr15:85201210 NMB 0.49 9.31 0.45 1.74e-18 Schizophrenia; LUSC cis rs7772486 0.875 rs1330939 chr6:146308518 T/A cg23711669 chr6:146136114 FBXO30 0.85 15.19 0.64 5.67e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs11971779 0.941 rs1127424 chr7:139107660 A/G cg07862535 chr7:139043722 LUC7L2 0.74 8.31 0.41 2.47e-15 Diisocyanate-induced asthma; LUSC cis rs9467773 0.620 rs9295701 chr6:26627508 T/C cg09904177 chr6:26538194 HMGN4 0.65 11.61 0.54 2.14e-26 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg13395646 chr4:1353034 KIAA1530 0.55 8.42 0.42 1.13e-15 Longevity; LUSC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.72 -0.35 7.97e-11 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.529 rs73235789 chr20:30196148 T/C cg18721089 chr20:30220636 NA -0.41 -6.57 -0.34 1.93e-10 Mean corpuscular hemoglobin; LUSC cis rs7973719 0.868 rs2053887 chr12:7346530 G/A cg07052231 chr12:7363540 PEX5 0.52 9.04 0.44 1.33e-17 IgG glycosylation; LUSC trans rs12524093 0.541 rs12525094 chr6:143042815 G/T cg22454011 chr18:13611439 C18orf1 0.68 5.96 0.31 6.53e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs593982 0.920 rs72922791 chr11:65567395 G/A cg08755490 chr11:65554678 OVOL1 -1.42 -14.72 -0.63 3.63e-38 Atopic dermatitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16053281 chr3:196387058 LRRC33 0.41 6.18 0.32 1.85e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1124376 1.000 rs9857135 chr3:20147790 G/A cg05072819 chr3:20081367 KAT2B 0.66 7.53 0.38 4.7e-13 Bipolar disorder and schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05741182 chr16:72127884 DHX38;TXNL4B -0.47 -6.06 -0.31 3.58e-9 Hepatitis; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.23 0.41 4.29e-15 Prudent dietary pattern; LUSC cis rs7824557 0.767 rs6991606 chr8:11176159 G/A cg21293242 chr8:11204541 TDH 0.34 6.47 0.33 3.56e-10 Retinal vascular caliber; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg24503407 chr1:205819492 PM20D1 0.93 17.97 0.7 5.5e-51 Menarche (age at onset); LUSC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg06618935 chr21:46677482 NA -0.37 -7.4 -0.38 1.09e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7246967 0.611 rs62120304 chr19:22872268 G/T cg23217946 chr19:22817039 ZNF492 0.45 6.01 0.31 4.91e-9 Bronchopulmonary dysplasia; LUSC cis rs4400599 0.901 rs2494670 chr1:154101057 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 0.37 6.01 0.31 4.87e-9 Platelet distribution width; LUSC cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg05805236 chr11:65401703 PCNXL3 -0.37 -5.74 -0.3 2.08e-8 Breast cancer; LUSC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg03676636 chr4:99064102 C4orf37 0.37 7.91 0.4 3.7e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg20849893 chr7:64541193 NA 0.46 6.59 0.34 1.67e-10 Calcium levels; LUSC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg27494647 chr7:150038898 RARRES2 0.42 6.54 0.34 2.27e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs9361491 0.605 rs1185343 chr6:79436190 G/C cg05283184 chr6:79620031 NA -0.34 -6.2 -0.32 1.66e-9 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10892866 chr1:154934115 PYGO2 -0.42 -6.26 -0.32 1.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9560113 1.000 rs9555805 chr13:112179765 C/T cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.54e-13 Menarche (age at onset); LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg11494091 chr17:61959527 GH2 0.65 13.92 0.61 4.91e-35 Prudent dietary pattern; LUSC cis rs796364 0.616 rs6710393 chr2:200697246 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.54 6.38 0.33 5.82e-10 Schizophrenia; LUSC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg17143192 chr8:8559678 CLDN23 -0.39 -6.02 -0.31 4.59e-9 Mood instability; LUSC cis rs9902453 0.817 rs55974138 chr17:28215546 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 10.05 0.48 6.11e-21 Coffee consumption (cups per day); LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.3 6.46 0.33 3.62e-10 Electroencephalogram traits; LUSC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg06494592 chr3:125709126 NA -0.52 -5.97 -0.31 6.04e-9 Blood pressure (smoking interaction); LUSC cis rs9355610 0.927 rs2757041 chr6:167370532 C/G cg23791538 chr6:167370224 RNASET2 0.55 9.21 0.45 3.58e-18 Graves' disease; LUSC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg08270630 chr22:50330655 NA -0.42 -6.29 -0.33 1e-9 Schizophrenia; LUSC cis rs67311347 0.544 rs2887965 chr3:40334154 A/G cg09455208 chr3:40491958 NA -0.41 -7.96 -0.4 2.64e-14 Renal cell carcinoma; LUSC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.92 0.31 8e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg18225595 chr11:63971243 STIP1 0.49 5.94 0.31 7.24e-9 Mean platelet volume; LUSC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg24675056 chr1:15929824 NA 0.45 7.76 0.39 1.03e-13 Systolic blood pressure; LUSC cis rs12286929 0.898 rs11215384 chr11:115023851 C/G cg04055981 chr11:115044050 NA 0.32 5.69 0.3 2.82e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6982240 0.514 rs28681435 chr8:142286573 C/A cg27411547 chr8:142287226 NA -0.47 -7.61 -0.38 2.91e-13 Tonsillectomy; LUSC cis rs780094 0.500 rs7577311 chr2:27793921 G/T cg27432699 chr2:27873401 GPN1 0.41 5.71 0.3 2.49e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC trans rs2324999 0.632 rs12494510 chr3:86189861 A/G cg20214535 chr21:43619310 ABCG1 0.36 6.18 0.32 1.91e-9 Subcutaneous adipose tissue; LUSC trans rs2268344 0.515 rs1009325 chr10:124263877 A/G cg11199862 chr13:46108984 COG3 -0.67 -5.99 -0.31 5.3300000000000004e-09 Coronary artery disease; LUSC cis rs2224391 0.628 rs2753234 chr6:5251050 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.59 -0.34 1.75e-10 Height; LUSC cis rs7512552 1.000 rs7512552 chr1:150265704 T/C cg15654264 chr1:150340011 RPRD2 -0.6 -10.0 -0.48 9.04e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs57590327 0.555 rs2053805 chr3:81738414 T/C cg07356753 chr3:81810745 GBE1 -0.68 -10.37 -0.49 5.11e-22 Extraversion; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg11965913 chr1:205819406 PM20D1 -0.79 -16.27 -0.66 3.17e-44 Monocyte percentage of white cells; LUSC cis rs12701220 0.504 rs12702092 chr7:1145868 G/A cg16145915 chr7:1198662 ZFAND2A -0.46 -5.89 -0.31 9.34e-9 Bronchopulmonary dysplasia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23850707 chr15:55582494 RAB27A -0.51 -5.99 -0.31 5.38e-9 Bipolar disorder and schizophrenia; LUSC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg21880101 chr17:80066754 CCDC57 -0.31 -5.93 -0.31 7.37e-9 Life satisfaction; LUSC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg11812906 chr14:75593930 NEK9 -0.62 -10.71 -0.51 3.29e-23 Height; LUSC cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.01 0.52 2.99e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7937682 0.632 rs11214028 chr11:111761149 T/C cg09085632 chr11:111637200 PPP2R1B 0.94 12.55 0.57 7.17e-30 Primary sclerosing cholangitis; LUSC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg03188948 chr7:1209495 NA 0.47 6.29 0.33 9.82e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12134245 0.874 rs34842487 chr1:92021611 C/T cg21854759 chr1:92012499 NA -0.41 -6.56 -0.34 2.02e-10 Breast cancer; LUSC cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.12 0.45 7.1e-18 Motion sickness; LUSC cis rs10876993 0.890 rs2640630 chr12:58067267 T/C cg15848620 chr12:58087721 OS9 -0.55 -7.92 -0.4 3.5e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs1048238 0.506 rs7552077 chr1:16196759 A/G cg22431228 chr1:16359049 CLCNKA -0.38 -8.09 -0.4 1.1e-14 Systolic blood pressure; LUSC cis rs422249 0.512 rs174578 chr11:61605499 T/A cg19610905 chr11:61596333 FADS2 -0.5 -7.58 -0.38 3.52e-13 Trans fatty acid levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg25613101 chr22:38577875 PLA2G6 -0.46 -6.98 -0.36 1.62e-11 Hepatitis; LUSC cis rs2760061 0.583 rs708113 chr1:228192753 T/A cg20976159 chr1:228193529 WNT3A 0.29 5.86 0.31 1.11e-8 Diastolic blood pressure; LUSC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg26335602 chr6:28129616 ZNF389 0.43 5.71 0.3 2.44e-8 Depression; LUSC trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg25482853 chr8:67687455 SGK3 1.19 19.24 0.73 4.65e-56 Lung disease severity in cystic fibrosis; LUSC cis rs1267303 0.716 rs942255 chr1:46989792 C/T cg25110126 chr1:46999211 NA 0.64 8.67 0.43 1.85e-16 Monobrow; LUSC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg22903471 chr2:27725779 GCKR -0.39 -6.62 -0.34 1.47e-10 Total body bone mineral density; LUSC cis rs3820928 0.874 rs67513858 chr2:227804819 A/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.14e-13 Pulmonary function; LUSC cis rs9341808 0.667 rs7745301 chr6:80922561 G/T cg08355045 chr6:80787529 NA 0.46 7.77 0.39 9.79e-14 Sitting height ratio; LUSC trans rs17278117 0.614 rs73010755 chr4:182595798 A/T cg11957848 chr6:169575326 NA 0.64 6.08 0.32 3.31e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg23711669 chr6:146136114 FBXO30 -0.82 -14.69 -0.63 5.14e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg23711669 chr6:146136114 FBXO30 -0.84 -15.75 -0.65 3.43e-42 Lobe attachment (rater-scored or self-reported); LUSC trans rs637571 0.510 rs4930320 chr11:65576788 C/G cg17712092 chr4:129076599 LARP1B -0.71 -10.28 -0.49 1.02e-21 Eosinophil percentage of white cells; LUSC cis rs7712401 0.601 rs385547 chr5:122321833 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.54 -0.46 3.21e-19 Mean platelet volume; LUSC cis rs2200578 0.732 rs56143125 chr2:99565143 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.61 6.99 0.36 1.55e-11 IgG glycosylation; LUSC cis rs17621444 0.505 rs10886562 chr10:121760594 G/A cg02041677 chr10:121771263 NA -0.35 -6.62 -0.34 1.46e-10 IgG glycosylation; LUSC cis rs1014246 0.826 rs4752004 chr10:118473209 A/G cg14919929 chr10:118506882 NA 0.42 6.63 0.34 1.36e-10 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs55871839 0.684 rs7829715 chr8:59803836 C/T cg07426533 chr8:59803705 TOX 0.37 6.08 0.32 3.35e-9 Pneumonia; LUSC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg02487422 chr3:49467188 NICN1 -0.45 -7.12 -0.36 6.5e-12 Resting heart rate; LUSC cis rs10927875 0.864 rs12744578 chr1:16173110 A/T cg21385522 chr1:16154831 NA -0.93 -15.56 -0.65 1.99e-41 Dilated cardiomyopathy; LUSC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg07701084 chr6:150067640 NUP43 0.49 7.38 0.37 1.31e-12 Lung cancer; LUSC cis rs7712401 0.791 rs3822367 chr5:122146272 A/G cg19077854 chr5:122220652 SNX24 -0.34 -7.87 -0.4 4.84e-14 Mean platelet volume; LUSC trans rs7829975 0.714 rs4841040 chr8:8654527 T/C cg21775007 chr8:11205619 TDH 0.46 6.4 0.33 5.17e-10 Mood instability; LUSC cis rs1949733 0.585 rs2631768 chr4:8473050 A/G cg11789530 chr4:8429930 ACOX3 -0.51 -7.79 -0.39 8.59e-14 Response to antineoplastic agents; LUSC cis rs10791323 0.569 rs11533204 chr11:133743644 A/G cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg09033563 chr22:24373618 LOC391322 -0.6 -9.36 -0.46 1.22e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.47 0.5 2.18e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs11971779 0.774 rs7785906 chr7:139122652 T/C cg07862535 chr7:139043722 LUC7L2 0.7 8.49 0.42 6.64e-16 Diisocyanate-induced asthma; LUSC cis rs7953249 0.791 rs10774579 chr12:121405210 T/C cg02403541 chr12:121454288 C12orf43 -0.5 -7.44 -0.38 8.81e-13 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC trans rs79057730 0.599 rs4333501 chr7:803244 C/T cg26647312 chr5:1645268 NA 0.6 6.07 0.32 3.38e-9 Initial pursuit acceleration; LUSC cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg16339924 chr4:17578868 LAP3 -0.53 -7.93 -0.4 3.27e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6714710 0.603 rs1470483 chr2:98393894 C/T cg26665480 chr2:98280029 ACTR1B 0.62 9.06 0.44 1.16e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg06618935 chr21:46677482 NA -0.39 -7.89 -0.4 4.43e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9325144 0.560 rs11182930 chr12:38633693 A/T cg26384229 chr12:38710491 ALG10B -0.67 -10.34 -0.49 6.58e-22 Morning vs. evening chronotype; LUSC cis rs1048238 0.506 rs6668183 chr1:16173814 G/C cg22431228 chr1:16359049 CLCNKA -0.4 -8.39 -0.42 1.42e-15 Systolic blood pressure; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.77 0.39 1e-13 Lymphocyte counts; LUSC cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg22782873 chr19:19639568 YJEFN3 -0.51 -6.29 -0.33 9.8e-10 Bipolar disorder; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg00166722 chr3:10149974 C3orf24 0.62 8.47 0.42 8.07e-16 Alzheimer's disease; LUSC cis rs7072216 0.727 rs6584199 chr10:100169983 A/G cg26618903 chr10:100175079 PYROXD2 -0.47 -8.86 -0.44 4.94e-17 Metabolite levels; LUSC cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg13770153 chr20:60521292 NA -0.61 -8.39 -0.42 1.43e-15 Body mass index; LUSC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg19774624 chr17:42201019 HDAC5 0.79 12.34 0.56 4.59e-29 Total body bone mineral density; LUSC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs3916 0.794 rs3021337 chr12:121163261 C/T cg27246729 chr12:121163418 ACADS 0.46 7.01 0.36 1.36e-11 Urinary metabolites (H-NMR features); LUSC cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg01849466 chr14:104193079 ZFYVE21 -0.55 -8.31 -0.41 2.35e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.68 -0.39 1.73e-13 Lymphocyte counts; LUSC cis rs9549367 0.662 rs3818334 chr13:113825174 C/G cg18105134 chr13:113819100 PROZ -0.76 -10.72 -0.51 3.12e-23 Platelet distribution width; LUSC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg25456477 chr12:86230367 RASSF9 0.43 7.71 0.39 1.41e-13 Major depressive disorder; LUSC cis rs11785400 0.762 rs2280880 chr8:143721929 C/A cg10596483 chr8:143751796 JRK 0.52 7.33 0.37 1.73e-12 Schizophrenia; LUSC cis rs11190604 1.000 rs7079136 chr10:102292709 T/C cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg07701084 chr6:150067640 NUP43 0.51 7.5 0.38 5.74e-13 Lung cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17040068 chr7:102715209 ARMC10;FBXL13 0.43 6.14 0.32 2.33e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4499344 0.921 rs2277927 chr19:33088366 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.59 7.76 0.39 1.04e-13 Mean platelet volume; LUSC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg22823121 chr1:150693482 HORMAD1 0.54 7.74 0.39 1.17e-13 Melanoma; LUSC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg06713675 chr4:122721982 EXOSC9 -0.47 -8.18 -0.41 6.02e-15 Type 2 diabetes; LUSC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg11366901 chr6:160182831 ACAT2 0.93 12.69 0.57 2.24e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg24060327 chr5:131705240 SLC22A5 0.67 11.13 0.52 1.13e-24 Breast cancer; LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg27284194 chr4:1044797 NA 0.37 6.03 0.31 4.46e-9 Longevity; LUSC cis rs7481584 0.624 rs440130 chr11:3051476 A/G cg25174290 chr11:3078921 CARS -0.41 -6.15 -0.32 2.19e-9 Calcium levels; LUSC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg20891283 chr12:69753455 YEATS4 0.91 17.47 0.69 5.52e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs17030434 0.911 rs17030490 chr4:154738340 C/T cg14289246 chr4:154710475 SFRP2 -0.56 -7.49 -0.38 6.18e-13 Electrocardiographic conduction measures; LUSC cis rs16867335 0.947 rs16867341 chr2:181488938 C/G cg23363182 chr2:181467187 NA -0.48 -6.06 -0.31 3.59e-9 Survival in rectal cancer; LUSC cis rs12042938 0.507 rs1655299 chr1:231732161 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.69 -11.21 -0.52 5.51e-25 Neuranatomic and neurocognitive phenotypes; LUSC cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg19812747 chr11:111475976 SIK2 0.49 6.67 0.34 1.05e-10 Primary sclerosing cholangitis; LUSC cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg08999081 chr20:33150536 PIGU -0.51 -10.33 -0.49 7e-22 Glomerular filtration rate (creatinine); LUSC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg22598563 chr5:131563921 P4HA2 -0.27 -5.72 -0.3 2.43e-8 Blood metabolite levels; LUSC cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg01689657 chr7:91764605 CYP51A1 0.32 5.83 0.3 1.32e-8 Breast cancer; LUSC cis rs877282 0.898 rs10904547 chr10:766283 C/T cg17470449 chr10:769945 NA 0.54 7.27 0.37 2.63e-12 Uric acid levels; LUSC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.17 -0.37 4.83e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9815354 0.812 rs113300894 chr3:41984243 G/C cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg10523679 chr1:76189770 ACADM 0.84 11.14 0.52 1e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs896854 0.573 rs13271375 chr8:95853907 A/G cg16049864 chr8:95962084 TP53INP1 -0.57 -10.41 -0.5 3.53e-22 Type 2 diabetes; LUSC cis rs9359856 0.564 rs17292768 chr6:90379311 T/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.86 -0.44 4.69e-17 Bipolar disorder; LUSC cis rs7923837 0.634 rs1544210 chr10:94487801 G/A cg25093409 chr10:94429542 NA -0.35 -5.95 -0.31 6.82e-9 Body mass index;Multiple sclerosis; LUSC cis rs2050392 0.517 rs656600 chr10:30765654 G/A cg25182066 chr10:30743637 MAP3K8 -0.46 -6.86 -0.35 3.41e-11 Inflammatory bowel disease; LUSC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg21862992 chr11:68658383 NA 0.51 8.11 0.41 9.65e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10489202 0.634 rs6427119 chr1:168074145 A/G cg24449463 chr1:168025552 DCAF6 0.62 9.33 0.45 1.52e-18 Schizophrenia; LUSC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg04450456 chr4:17643702 FAM184B 0.41 7.04 0.36 1.08e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg18681998 chr4:17616180 MED28 0.84 15.32 0.64 1.65e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7520050 0.966 rs11589562 chr1:46466721 C/T cg27013360 chr6:41040518 NFYA;C6orf130 -0.43 -6.18 -0.32 1.86e-9 Red blood cell count;Reticulocyte count; LUSC cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg26446133 chr18:72167187 CNDP2 -0.85 -13.41 -0.59 4.32e-33 Refractive error; LUSC cis rs611744 0.647 rs1448151 chr8:109276283 C/A cg21045802 chr8:109455806 TTC35 0.43 6.67 0.34 1.06e-10 Dupuytren's disease; LUSC cis rs4903604 0.581 rs41347855 chr14:78037909 C/T cg18872420 chr14:78023429 SPTLC2 0.39 6.02 0.31 4.65e-9 Gut microbiome composition (winter); LUSC cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg15423357 chr2:25149977 NA 0.4 7.99 0.4 2.14e-14 Body mass index; LUSC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg11657440 chr19:46296263 DMWD -0.72 -11.15 -0.52 9.34e-25 Coronary artery disease; LUSC cis rs6060717 0.529 rs6060535 chr20:34235522 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.23 -0.32 1.41e-9 Hip circumference adjusted for BMI; LUSC trans rs4714291 0.832 rs1923462 chr6:39976100 T/C cg02267698 chr19:7991119 CTXN1 -0.52 -7.64 -0.39 2.27e-13 Strep throat; LUSC cis rs4065321 0.522 rs3744245 chr17:38146542 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.69 12.27 0.56 8.27e-29 White blood cell count (basophil);White blood cell count; LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg18404041 chr3:52824283 ITIH1 0.54 10.27 0.49 1.09e-21 Bipolar disorder; LUSC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg08048268 chr3:133502702 NA -0.47 -9.26 -0.45 2.58e-18 Iron status biomarkers; LUSC cis rs62408225 1.000 rs55881869 chr6:90968025 C/A cg06866423 chr6:90926672 BACH2 0.4 5.75 0.3 2.02e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs400736 0.602 rs11121090 chr1:8168634 A/G cg25007680 chr1:8021821 PARK7 0.45 6.8 0.35 4.78e-11 Response to antidepressants and depression; LUSC cis rs9420 0.961 rs12146541 chr11:57508678 G/C cg02958346 chr11:57425731 CLP1 -0.44 -6.35 -0.33 6.86e-10 Schizophrenia; LUSC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg08355456 chr11:67383691 NA -0.43 -8.14 -0.41 7.73e-15 Mean corpuscular volume; LUSC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg06221963 chr1:154839813 KCNN3 -0.61 -13.87 -0.6 7.21e-35 Prostate cancer; LUSC cis rs941408 1.000 rs1736176 chr19:2790394 G/A cg06609049 chr19:2785107 THOP1 0.72 11.34 0.53 1.88e-25 Total cholesterol levels; LUSC cis rs3815700 0.841 rs10410895 chr19:33093655 T/G cg02997394 chr19:33096574 ANKRD27 0.79 8.95 0.44 2.44e-17 Eosinophilic esophagitis; LUSC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg05340658 chr4:99064831 C4orf37 0.65 11.16 0.52 8.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg24562669 chr7:97807699 LMTK2 0.36 6.23 0.32 1.4e-9 Breast cancer; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg11494091 chr17:61959527 GH2 0.65 13.92 0.61 4.91e-35 Prudent dietary pattern; LUSC trans rs9291683 0.527 rs3822247 chr4:10094671 G/A cg26043149 chr18:55253948 FECH -0.51 -7.47 -0.38 7.17e-13 Bone mineral density; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08941173 chr11:125034971 PKNOX2 -0.45 -6.06 -0.31 3.68e-9 Bipolar disorder and schizophrenia; LUSC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg10117171 chr1:25599238 RHD -0.4 -6.22 -0.32 1.45e-9 Erythrocyte sedimentation rate; LUSC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg19717773 chr7:2847554 GNA12 -0.39 -6.41 -0.33 5.08e-10 Height; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg00431813 chr7:1051703 C7orf50 -0.43 -6.76 -0.35 6.12e-11 Longevity;Endometriosis; LUSC cis rs9733 0.650 rs11204668 chr1:150543686 G/A cg17724175 chr1:150552817 MCL1 -0.34 -5.84 -0.3 1.24e-8 Tonsillectomy; LUSC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.89 -0.31 9.56e-9 Tonsillectomy; LUSC cis rs5758659 1.000 rs5758660 chr22:42623718 C/A cg15557168 chr22:42548783 NA -0.43 -7.23 -0.37 3.25e-12 Cognitive function; LUSC cis rs453301 0.598 rs2921383 chr8:8892221 C/T cg06636001 chr8:8085503 FLJ10661 0.62 9.65 0.47 1.31e-19 Joint mobility (Beighton score); LUSC cis rs1858037 0.867 rs1039765 chr2:65614362 A/T cg08085232 chr2:65598271 SPRED2 0.41 6.19 0.32 1.78e-9 Rheumatoid arthritis; LUSC cis rs1034435 0.692 rs6008739 chr22:48892542 T/C cg05992904 chr22:48892994 FAM19A5 -0.41 -8.26 -0.41 3.44e-15 Late-onset Alzheimer's disease; LUSC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg12560992 chr17:57184187 TRIM37 -0.84 -15.48 -0.65 3.83e-41 Intelligence (multi-trait analysis); LUSC cis rs826838 0.967 rs826879 chr12:39088999 A/C cg26384229 chr12:38710491 ALG10B -0.84 -15.97 -0.66 4.85e-43 Heart rate; LUSC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg09021430 chr5:549028 NA -0.56 -8.68 -0.43 1.83e-16 Ulcerative colitis; LUSC cis rs4595586 0.545 rs4438082 chr12:39363870 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC cis rs977987 0.843 rs10431974 chr16:75435461 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.85e-10 Dupuytren's disease; LUSC cis rs9393777 0.623 rs9358944 chr6:26469875 A/C cg12292205 chr6:26970375 C6orf41 -0.63 -7.39 -0.37 1.23e-12 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg04414720 chr1:150670196 GOLPH3L -0.38 -5.75 -0.3 2.07e-8 Tonsillectomy; LUSC trans rs8073060 0.586 rs7214250 chr17:33981704 C/G cg19694781 chr19:47549865 TMEM160 -1.15 -18.01 -0.7 3.78e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg03036452 chr22:46663545 TTC38 0.52 5.7 0.3 2.69e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg04287289 chr16:89883240 FANCA 0.51 7.84 0.39 6.27e-14 Vitiligo; LUSC trans rs7824557 0.564 rs6601584 chr8:11232343 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.19 -0.41 5.74e-15 Retinal vascular caliber; LUSC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08018356 chr19:36706053 ZNF146;ZNF565 -0.42 -7.15 -0.36 5.47e-12 Electrocardiographic conduction measures; LUSC cis rs9399135 0.869 rs9402675 chr6:135325794 C/G cg24558204 chr6:135376177 HBS1L 0.59 9.12 0.45 7.4e-18 Red blood cell count; LUSC trans rs4332037 0.539 rs34809719 chr7:2028968 G/T cg10840412 chr1:235813424 GNG4 0.59 7.54 0.38 4.39e-13 Bipolar disorder; LUSC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg07936489 chr17:37558343 FBXL20 0.71 10.04 0.48 6.69e-21 Glomerular filtration rate (creatinine); LUSC cis rs11758351 1.000 rs11754744 chr6:26202605 G/A cg23601095 chr6:26197514 HIST1H3D 0.75 7.59 0.38 3.21e-13 Gout;Renal underexcretion gout; LUSC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg02931644 chr1:25747376 RHCE 0.38 7.09 0.36 7.98e-12 Plateletcrit;Mean corpuscular volume; LUSC trans rs1908814 0.516 rs4367597 chr8:11793529 C/T cg08975724 chr8:8085496 FLJ10661 0.48 6.96 0.36 1.79e-11 Neuroticism; LUSC cis rs829883 0.659 rs12366950 chr12:98947900 T/C cg25150519 chr12:98850993 NA -0.64 -8.77 -0.43 9.6e-17 Colorectal adenoma (advanced); LUSC cis rs80282103 0.764 rs12268949 chr10:1104257 A/G cg08668510 chr10:1095578 IDI1 0.73 6.41 0.33 4.88e-10 Glomerular filtration rate (creatinine); LUSC cis rs765787 0.530 rs1648286 chr15:45517386 G/C cg24006582 chr15:45444508 DUOX1 -0.62 -9.14 -0.45 6.18e-18 Uric acid levels; LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.87 -0.31 1.07e-8 Platelet count; LUSC cis rs3845702 1.000 rs3738943 chr2:180846743 G/T cg01881094 chr2:180872142 CWC22 -0.82 -10.69 -0.5 3.83e-23 Schizophrenia; LUSC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg06112835 chr11:68658793 MRPL21 0.52 7.61 0.38 2.87e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9796 0.558 rs6492993 chr15:41526104 G/A cg18705301 chr15:41695430 NDUFAF1 -0.49 -8.54 -0.42 4.71e-16 Menopause (age at onset); LUSC cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg13010199 chr12:38710504 ALG10B 0.66 10.13 0.48 3.22e-21 Bladder cancer; LUSC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.55 5.81 0.3 1.43e-8 Cerebrospinal P-tau181p levels; LUSC cis rs7202877 0.610 rs4536500 chr16:75343197 C/G cg03315344 chr16:75512273 CHST6 -0.4 -5.82 -0.3 1.36e-8 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9837602 1.000 rs4075038 chr3:99680086 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -6.48 -0.33 3.27e-10 Breast cancer; LUSC cis rs4631830 0.863 rs2249986 chr10:51521684 T/G cg20129853 chr10:51489980 NA -0.34 -6.84 -0.35 3.8e-11 Prostate-specific antigen levels; LUSC cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.35e-22 Alzheimer's disease (late onset); LUSC cis rs10743315 0.778 rs9805106 chr12:19372357 A/G cg02471346 chr12:19282374 PLEKHA5 -0.53 -6.68 -0.34 1.01e-10 Gut microbiota (bacterial taxa); LUSC cis rs1784581 0.588 rs1784583 chr6:162410132 C/T cg17173639 chr6:162384350 PARK2 -0.55 -9.5 -0.46 4.06e-19 Itch intensity from mosquito bite; LUSC cis rs3815700 1.000 rs7247420 chr19:33096786 G/A cg02997394 chr19:33096574 ANKRD27 0.82 8.98 0.44 1.96e-17 Eosinophilic esophagitis; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg03354898 chr7:1950403 MAD1L1 -0.42 -8.41 -0.42 1.23e-15 Bipolar disorder and schizophrenia; LUSC cis rs919433 0.679 rs10931788 chr2:198531084 A/G cg00792783 chr2:198669748 PLCL1 0.42 5.68 0.3 3e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC trans rs561341 1.000 rs501957 chr17:30314504 C/T cg27661571 chr11:113659931 NA -0.71 -7.88 -0.4 4.61e-14 Hip circumference adjusted for BMI; LUSC trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg03929089 chr4:120376271 NA -0.55 -6.81 -0.35 4.54e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg24154853 chr7:158122151 PTPRN2 -0.42 -8.27 -0.41 3.16e-15 Calcium levels; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg16606324 chr3:10149918 C3orf24 0.58 8.47 0.42 8.16e-16 Alzheimer's disease; LUSC cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg00012203 chr2:219082015 ARPC2 0.89 17.08 0.68 1.8e-47 Colorectal cancer; LUSC cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg04455712 chr21:45112962 RRP1B 0.44 8.58 0.43 3.54e-16 Mean corpuscular volume; LUSC cis rs7605827 0.930 rs1035247 chr2:15617846 T/A cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.28e-9 Menopause (age at onset); LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 20.77 0.75 4.03e-62 Prudent dietary pattern; LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg12432903 chr7:1882776 MAD1L1 -0.36 -5.82 -0.3 1.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg17279839 chr7:150038598 RARRES2 0.45 6.93 0.35 2.24e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg22681709 chr2:178499509 PDE11A -0.51 -9.02 -0.44 1.5e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.76 0.84 8.98e-89 Chronic sinus infection; LUSC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg15147215 chr3:52552868 STAB1 -0.29 -5.76 -0.3 1.93e-8 Electroencephalogram traits; LUSC cis rs9837602 1.000 rs923470 chr3:99757792 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.18 0.32 1.82e-9 Breast cancer; LUSC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg10523679 chr1:76189770 ACADM -0.88 -14.16 -0.61 5.75e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg05283184 chr6:79620031 NA -0.46 -8.78 -0.43 8.59e-17 Intelligence (multi-trait analysis); LUSC cis rs7113850 0.541 rs80336897 chr11:24224545 G/T ch.11.24196551F chr11:24239977 NA 1.0 8.93 0.44 2.94e-17 Bone fracture in osteoporosis; LUSC trans rs2018683 0.677 rs55718000 chr7:28975625 T/C cg19402173 chr7:128379420 CALU -0.47 -7.22 -0.37 3.47e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs2439831 1.000 rs527921 chr15:43770416 G/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.97 -11.76 -0.54 5.73e-27 Lung cancer in ever smokers; LUSC cis rs240764 0.817 rs12207086 chr6:101150463 G/A cg09795085 chr6:101329169 ASCC3 -0.41 -6.02 -0.31 4.68e-9 Neuroticism; LUSC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg21918786 chr6:109611834 NA -0.42 -7.28 -0.37 2.36e-12 Reticulocyte fraction of red cells; LUSC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg02475777 chr4:1388615 CRIPAK -0.47 -7.03 -0.36 1.14e-11 Obesity-related traits; LUSC cis rs10189230 0.967 rs12993766 chr2:222350321 C/T cg14652038 chr2:222343519 EPHA4 0.33 5.93 0.31 7.56e-9 Urate levels in lean individuals; LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg08219700 chr8:58056026 NA 0.66 7.76 0.39 1.04e-13 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg11764359 chr7:65958608 NA 0.7 10.66 0.5 5e-23 Aortic root size; LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg00166722 chr3:10149974 C3orf24 0.54 7.0 0.36 1.43e-11 Alzheimer's disease; LUSC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg04414720 chr1:150670196 GOLPH3L 0.53 8.39 0.42 1.43e-15 Melanoma; LUSC cis rs11997175 1.000 rs11997175 chr8:33770070 A/G ch.8.33884649F chr8:33765107 NA -0.53 -8.63 -0.43 2.53e-16 Body mass index; LUSC cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg08213375 chr14:104286397 PPP1R13B 0.41 7.98 0.4 2.37e-14 Schizophrenia; LUSC trans rs7824557 0.545 rs2572380 chr8:11237477 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.47 -0.38 7.29e-13 Retinal vascular caliber; LUSC cis rs9905704 0.647 rs12943705 chr17:57097047 T/C cg12560992 chr17:57184187 TRIM37 -0.64 -10.66 -0.5 5.06e-23 Testicular germ cell tumor; LUSC cis rs67072384 1.000 rs72964198 chr11:72446464 C/T cg04827223 chr11:72435913 ARAP1 -0.8 -7.17 -0.37 4.78e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9660992 0.548 rs1172152 chr1:205220718 T/A cg00857998 chr1:205179979 DSTYK 0.62 9.55 0.46 2.88e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.59 -0.5 8.72e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9341808 0.690 rs2322634 chr6:80874014 A/C cg08355045 chr6:80787529 NA 0.57 9.9 0.48 1.96e-20 Sitting height ratio; LUSC cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg04586622 chr2:25135609 ADCY3 0.41 8.52 0.42 5.67e-16 Body mass index in non-asthmatics; LUSC cis rs12519773 0.526 rs4242241 chr5:92518370 C/T cg18783429 chr5:92414398 NA 0.33 7.18 0.37 4.67e-12 Migraine; LUSC cis rs11677416 1.000 rs3783555 chr2:113531093 T/C cg27083787 chr2:113543245 IL1A 0.46 7.27 0.37 2.57e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 9.07 0.44 1.03e-17 Tonsillectomy; LUSC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg03517284 chr6:25882590 NA -0.71 -11.67 -0.54 1.26e-26 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.673 rs9841194 chr3:125635739 C/T cg05084668 chr3:125655381 ALG1L -0.92 -13.12 -0.58 5.09e-32 Blood pressure (smoking interaction); LUSC cis rs9506514 0.509 rs9509279 chr13:21133719 C/G cg11940495 chr13:21141764 IFT88 -0.31 -5.88 -0.31 9.94e-9 Coronary artery calcification; LUSC cis rs7927592 0.546 rs683978 chr11:68192421 T/C cg20283391 chr11:68216788 NA -0.52 -7.24 -0.37 3.01e-12 Total body bone mineral density; LUSC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg24562669 chr7:97807699 LMTK2 0.33 5.8 0.3 1.54e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs4908769 0.624 rs1763839 chr1:8473336 G/A cg00546117 chr1:8445545 RERE -0.3 -6.07 -0.31 3.57e-9 Allergy; LUSC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.33 0.53 2.12e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs1728785 0.681 rs4783649 chr16:68558467 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.57 -6.85 -0.35 3.63e-11 Ulcerative colitis; LUSC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg02423579 chr7:2872169 GNA12 -0.44 -6.02 -0.31 4.66e-9 Height; LUSC cis rs11756438 0.572 rs2638544 chr6:119001978 G/A cg21191810 chr6:118973309 C6orf204 0.34 5.81 0.3 1.46e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7527798 0.592 rs11118359 chr1:207858546 T/C cg09232269 chr1:207846808 CR1L -0.3 -6.31 -0.33 9.11e-10 Erythrocyte sedimentation rate; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg12419862 chr22:24373484 LOC391322 -0.88 -14.3 -0.62 1.55e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg19077165 chr18:44547161 KATNAL2 0.45 6.67 0.34 1.04e-10 Personality dimensions; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg05205152 chr19:15529855 AKAP8L 0.38 6.37 0.33 6.42e-10 Metabolite levels (Pyroglutamine); LUSC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.67 -10.3 -0.49 8.58e-22 Monocyte percentage of white cells; LUSC cis rs9902453 0.967 rs28792710 chr17:28450015 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.87 0.4 4.86e-14 Coffee consumption (cups per day); LUSC cis rs3892630 0.588 rs8106748 chr19:33282797 G/A cg22980127 chr19:33182716 NUDT19 0.9 12.92 0.58 3.03e-31 Red blood cell traits; LUSC cis rs11997175 0.625 rs7018213 chr8:33625770 T/C ch.8.33884649F chr8:33765107 NA 0.45 7.18 0.37 4.54e-12 Body mass index; LUSC cis rs7647973 0.826 rs9834535 chr3:49378797 A/T cg07636037 chr3:49044803 WDR6 0.67 8.77 0.43 9.04e-17 Menarche (age at onset); LUSC cis rs2404602 0.735 rs2436994 chr15:76801063 G/C cg23625390 chr15:77176239 SCAPER -0.54 -8.48 -0.42 7.13e-16 Blood metabolite levels; LUSC cis rs12711979 0.509 rs10195596 chr2:3824222 T/G cg17052675 chr2:3827356 NA -0.83 -20.1 -0.74 1.83e-59 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs12575480 0.637 rs74048176 chr11:2096908 C/T cg15541987 chr11:2077307 NA -0.43 -6.32 -0.33 8.23e-10 Pursuit maintenance gain; LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.68 0.34 9.71e-11 Menopause (age at onset); LUSC cis rs2075165 1.000 rs2075165 chr1:156215899 G/A cg20302342 chr1:156215951 PAQR6 0.32 6.13 0.32 2.49e-9 Tonsillectomy; LUSC cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg18681998 chr4:17616180 MED28 0.83 14.91 0.63 6.86e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.74 0.3 2.09e-8 Life satisfaction; LUSC trans rs539514 0.690 rs480929 chr13:76312773 G/A cg05302441 chr11:125157402 PKNOX2 0.26 6.04 0.31 4.13e-9 Type 1 diabetes; LUSC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg12311346 chr5:56204834 C5orf35 -0.58 -8.93 -0.44 2.89e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg11645453 chr3:52864694 ITIH4 0.34 7.97 0.4 2.52e-14 Bipolar disorder; LUSC cis rs7397814 0.558 rs4764447 chr12:9579109 C/T cg27502298 chr12:9555721 NA 0.75 12.66 0.57 2.8e-30 IgG glycosylation; LUSC cis rs7726839 0.540 rs72703079 chr5:595173 T/C cg16624210 chr5:671434 TPPP 0.5 6.47 0.33 3.58e-10 Obesity-related traits; LUSC cis rs244731 0.959 rs7724098 chr5:176659570 G/A cg16006841 chr5:176797999 RGS14 -0.67 -9.33 -0.45 1.46e-18 Urate levels in lean individuals; LUSC cis rs9790314 0.779 rs1599376 chr3:160900533 C/G cg03342759 chr3:160939853 NMD3 -0.36 -5.7 -0.3 2.58e-8 Morning vs. evening chronotype; LUSC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg03806693 chr22:41940476 POLR3H 1.0 14.38 0.62 7.59e-37 Vitiligo; LUSC cis rs1124376 1.000 rs17006610 chr3:20152563 G/A cg05072819 chr3:20081367 KAT2B 0.68 8.16 0.41 7.07e-15 Bipolar disorder and schizophrenia; LUSC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.87 13.15 0.58 4.16e-32 Multiple sclerosis; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg02257048 chr17:78880031 RPTOR -0.39 -6.0 -0.31 5.01e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1577917 0.771 rs7742201 chr6:86432930 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.64 -9.85 -0.47 2.85e-20 Response to antipsychotic treatment; LUSC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg26335602 chr6:28129616 ZNF389 0.44 5.88 0.31 9.91e-9 Parkinson's disease; LUSC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg11812906 chr14:75593930 NEK9 -0.64 -10.48 -0.5 2.01e-22 Height; LUSC cis rs1403694 0.695 rs5029975 chr3:186436918 A/G cg12454167 chr3:186435060 KNG1 -0.29 -7.43 -0.38 9.26e-13 Blood protein levels; LUSC trans rs7829975 0.658 rs907181 chr8:8702875 T/C cg21775007 chr8:11205619 TDH 0.46 6.64 0.34 1.3e-10 Mood instability; LUSC cis rs2304069 0.954 rs9324640 chr5:149413186 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.75 -10.22 -0.49 1.66e-21 HIV-1 control; LUSC cis rs9486719 1.000 rs11152968 chr6:96908653 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.87 0.48 2.51e-20 Migraine;Coronary artery disease; LUSC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg05738196 chr6:26577821 NA 0.49 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg26354017 chr1:205819088 PM20D1 0.84 15.14 0.64 8.94e-40 Menarche (age at onset); LUSC cis rs75804782 0.641 rs11904390 chr2:239344663 T/A cg18131467 chr2:239335373 ASB1 -0.72 -6.54 -0.34 2.25e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7712401 0.755 rs965821 chr5:122137708 A/G cg19077854 chr5:122220652 SNX24 0.32 7.07 0.36 9.18e-12 Mean platelet volume; LUSC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -7.05 -0.36 1.01e-11 Alzheimer's disease (late onset); LUSC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg06634786 chr22:41940651 POLR3H -0.58 -6.52 -0.34 2.61e-10 Vitiligo; LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg02018176 chr4:1364513 KIAA1530 0.48 7.89 0.4 4.27e-14 Obesity-related traits; LUSC trans rs1941687 0.669 rs56171873 chr18:31400635 G/C cg27147174 chr7:100797783 AP1S1 -0.43 -6.56 -0.34 2.11e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs6516091 0.850 rs11699483 chr20:6048460 G/A cg25325723 chr20:6104886 FERMT1 -0.69 -7.2 -0.37 4.01e-12 Abdominal aortic aneurysm; LUSC cis rs3018712 0.532 rs948863 chr11:68420974 G/A cg22747802 chr11:68417633 NA -0.43 -5.94 -0.31 7.02e-9 Total body bone mineral density; LUSC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg17971929 chr21:40555470 PSMG1 -0.67 -10.92 -0.51 6.01e-24 Cognitive function; LUSC cis rs9815354 1.000 rs9818169 chr3:41860599 A/G cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.55e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs7192380 1.000 rs8061052 chr16:69656532 G/A cg26679644 chr16:69762563 NA 0.34 6.14 0.32 2.41e-9 Sjögren's syndrome; LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs921968 0.541 rs3845835 chr2:219342284 T/C cg02176678 chr2:219576539 TTLL4 -0.74 -14.3 -0.62 1.59e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs7586879 0.964 rs4077680 chr2:25122942 A/G cg04586622 chr2:25135609 ADCY3 0.32 6.22 0.32 1.51e-9 Body mass index; LUSC cis rs12541635 0.966 rs4416800 chr8:106996677 T/C cg10147462 chr8:107024639 NA 0.55 9.97 0.48 1.14e-20 Age of smoking initiation; LUSC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg09267113 chr7:98030324 BAIAP2L1 0.4 6.02 0.31 4.66e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs7615952 0.605 rs34865555 chr3:125304134 C/T cg07211511 chr3:129823064 LOC729375 -0.64 -6.33 -0.33 8.06e-10 Blood pressure (smoking interaction); LUSC cis rs2288073 0.562 rs112892911 chr2:24590800 G/A cg06627628 chr2:24431161 ITSN2 -0.86 -12.35 -0.56 4.17e-29 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs7633770 0.786 rs1520489 chr3:46677519 A/G cg11219411 chr3:46661640 NA -0.37 -7.56 -0.38 3.92e-13 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25890275 chr11:60929200 VPS37C 0.44 6.18 0.32 1.82e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1881797 0.527 rs79724455 chr1:247646957 T/C cg14830002 chr1:247616686 OR2B11 0.65 7.43 0.38 9.39e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs208520 0.661 rs207090 chr6:66783963 T/A cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs2625529 0.591 rs7172158 chr15:72405313 T/C cg16672083 chr15:72433130 SENP8 0.48 7.88 0.4 4.69e-14 Red blood cell count; LUSC cis rs8113142 0.614 rs55647098 chr19:29148429 T/G cg04546413 chr19:29218101 NA 0.45 6.09 0.32 3.11e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.65 -0.34 1.18e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs62400317 0.762 rs12212190 chr6:44926271 T/C cg18551225 chr6:44695536 NA -0.45 -7.26 -0.37 2.75e-12 Total body bone mineral density; LUSC cis rs7809950 0.817 rs2712224 chr7:107181235 C/A cg23024343 chr7:107201750 COG5 -0.69 -9.89 -0.48 2.08e-20 Coronary artery disease; LUSC trans rs2204008 0.685 rs4556621 chr12:38187236 C/A cg06521331 chr12:34319734 NA -0.39 -5.96 -0.31 6.46e-9 Bladder cancer; LUSC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.13 0.36 6.11e-12 Cognitive ability; LUSC cis rs67460515 0.892 rs4856756 chr3:160999414 G/A cg03342759 chr3:160939853 NMD3 -0.54 -8.06 -0.4 1.36e-14 Parkinson's disease; LUSC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg11301795 chr4:187892539 NA 0.76 14.56 0.62 1.53e-37 Lobe attachment (rater-scored or self-reported); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22897130 chr10:89419623 PAPSS2 -0.47 -5.99 -0.31 5.55e-9 Bipolar disorder and schizophrenia; LUSC cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg03146154 chr1:46216737 IPP -0.51 -7.57 -0.38 3.61e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4792901 0.802 rs79934399 chr17:41571961 C/T cg22562494 chr17:41607896 ETV4 -0.33 -6.07 -0.32 3.52e-9 Dupuytren's disease; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg03354898 chr7:1950403 MAD1L1 -0.33 -6.43 -0.33 4.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs28453840 1 rs28453840 chr2:136522941 G/A cg25344623 chr2:136566232 LCT 0.37 5.71 0.3 2.51e-8 Cholesterol, total; LUSC cis rs6906287 0.625 rs7764280 chr6:118692514 A/G cg05564266 chr6:118973597 C6orf204 0.24 5.74 0.3 2.11e-8 Electrocardiographic conduction measures; LUSC cis rs7264396 1.000 rs224430 chr20:34153341 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.39 -0.37 1.17e-12 Total cholesterol levels; LUSC cis rs12893668 0.703 rs12894729 chr14:104035292 G/A cg01849466 chr14:104193079 ZFYVE21 -0.47 -6.44 -0.33 4.08e-10 Reticulocyte count; LUSC cis rs11098499 0.722 rs28713555 chr4:120251995 C/T cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs6480314 0.831 rs7904069 chr10:69980193 T/C cg06988349 chr10:69991859 ATOH7 0.36 5.92 0.31 7.94e-9 Optic nerve measurement (disc area); LUSC trans rs7937682 0.847 rs11213948 chr11:111464401 G/A cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs4631830 0.720 rs2611471 chr10:51503559 G/C cg20129853 chr10:51489980 NA -0.36 -7.58 -0.38 3.46e-13 Prostate-specific antigen levels; LUSC cis rs2456568 0.503 rs11020603 chr11:93667439 A/G cg26875233 chr11:93583750 C11orf90 0.3 5.75 0.3 1.97e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC trans rs61931739 0.534 rs7310499 chr12:34212112 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.62 0.43 2.81e-16 Morning vs. evening chronotype; LUSC cis rs3806843 0.546 rs246023 chr5:140333990 G/T cg19875535 chr5:140030758 IK 0.37 5.67 0.3 3.1e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7833986 1.000 rs4263734 chr8:57099931 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 9.18 0.45 4.7e-18 Height; LUSC cis rs10751667 0.621 rs10794348 chr11:939941 G/A ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs2073300 0.609 rs6137941 chr20:23400848 G/A cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg00376283 chr12:123451042 ABCB9 0.65 8.33 0.41 2.18e-15 Neutrophil percentage of white cells; LUSC cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.37 -0.42 1.65e-15 Body mass index; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.52 -7.78 -0.39 9.01e-14 Lymphocyte counts; LUSC cis rs6754311 0.731 rs4954490 chr2:136608231 G/A cg15123519 chr2:136567270 LCT 0.4 6.12 0.32 2.64e-9 Mosquito bite size; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg00024416 chr22:24240387 NA -0.34 -6.22 -0.32 1.48e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg20607287 chr7:12443886 VWDE -0.65 -6.44 -0.33 4.17e-10 Coronary artery disease; LUSC trans rs1728785 1.000 rs1170431 chr16:68605639 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs2901656 0.677 rs10752957 chr1:172408271 A/G cg03748243 chr1:172413542 C1orf105;PIGC 0.38 7.96 0.4 2.79e-14 Red cell distribution width;Platelet distribution width; LUSC cis rs9362426 0.887 rs1209113 chr6:88079456 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.38 6.06 0.31 3.67e-9 Depressive episodes in bipolar disorder; LUSC cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs2816062 0.813 rs2745318 chr1:18895844 C/T cg18795169 chr1:18902165 NA 0.99 23.49 0.79 9.94e-73 Urate levels in lean individuals; LUSC trans rs12458462 0.892 rs2007483 chr18:77476131 A/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.5 -7.19 -0.37 4.23e-12 Monocyte count; LUSC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg00343986 chr7:65444356 GUSB 0.47 7.07 0.36 9.07e-12 Calcium levels; LUSC cis rs1577917 0.771 rs2842609 chr6:86296788 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -8.57 -0.42 3.85e-16 Response to antipsychotic treatment; LUSC trans rs2251301 0.882 rs55690252 chr8:11117335 A/G cg03839776 chr17:7750866 KDM6B 0.62 5.96 0.31 6.38e-9 Response to antipsychotic therapy (extrapyramidal side effects); LUSC cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg14530993 chr4:882597 GAK 0.73 7.54 0.38 4.37e-13 Intelligence (multi-trait analysis); LUSC cis rs6464929 0.955 rs6464930 chr7:148720906 C/T cg23583168 chr7:148888333 NA 0.46 5.8 0.3 1.54e-8 Pediatric bone mineral content (hip); LUSC cis rs10504229 0.516 rs58244172 chr8:57987805 G/A cg11062466 chr8:58055876 NA 0.38 5.68 0.3 2.98e-8 Developmental language disorder (linguistic errors); LUSC trans rs2727020 0.615 rs35423199 chr11:49514914 T/C cg03929089 chr4:120376271 NA -0.99 -17.63 -0.69 1.24e-49 Coronary artery disease; LUSC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg03732007 chr1:2071316 PRKCZ 0.36 6.05 0.31 3.82e-9 Coronary artery disease; LUSC cis rs72781680 0.898 rs56315094 chr2:23941952 T/C cg08917208 chr2:24149416 ATAD2B 0.88 9.59 0.46 2.06e-19 Lymphocyte counts; LUSC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg03351412 chr1:154909251 PMVK 0.53 8.19 0.41 5.74e-15 Prostate cancer; LUSC cis rs74544699 1.000 rs11574452 chr4:74846661 A/C cg06834998 chr4:74847824 PF4 -0.82 -6.26 -0.32 1.2e-9 Growth-regulated protein alpha levels; LUSC cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg27446573 chr6:127587934 RNF146 0.91 15.18 0.64 5.84e-40 Breast cancer; LUSC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg21984481 chr17:79567631 NPLOC4 -0.72 -15.48 -0.65 3.94e-41 Eye color traits; LUSC cis rs4443100 0.917 rs725984 chr22:23387642 A/G cg21100191 chr22:23484243 RTDR1 0.47 5.69 0.3 2.8e-8 Serum parathyroid hormone levels; LUSC cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -8.1 -0.41 1.06e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs72901758 0.768 rs11657271 chr17:76249682 A/T cg26068271 chr17:76253126 NA 0.64 11.8 0.54 4.15e-27 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.77 -13.38 -0.59 5.59e-33 Total body bone mineral density; LUSC cis rs2116941 0.523 rs17000211 chr19:10369086 C/T cg01850179 chr19:10340795 S1PR2 0.61 10.16 0.49 2.71e-21 Pulse pressure; LUSC trans rs6601327 0.571 rs7820675 chr8:9647748 C/G cg06636001 chr8:8085503 FLJ10661 0.51 7.53 0.38 4.67e-13 Multiple myeloma (hyperdiploidy); LUSC cis rs4803468 1.000 rs8105833 chr19:41896145 G/A cg09537434 chr19:41945824 ATP5SL -0.88 -15.5 -0.65 3.41e-41 Height; LUSC cis rs11677416 1.000 rs1878319 chr2:113544826 G/A cg27083787 chr2:113543245 IL1A 0.45 7.13 0.36 6.29e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs12472274 0.618 rs12477307 chr2:239110514 G/T cg17459225 chr2:239074497 NA 0.52 8.66 0.43 2.08e-16 Phospholipid levels (plasma); LUSC cis rs1670533 0.932 rs4690214 chr4:1054636 T/C cg27284194 chr4:1044797 NA 0.59 8.8 0.43 7.59e-17 Recombination rate (females); LUSC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg04181038 chr4:183730758 NA 0.84 12.95 0.58 2.29e-31 Pediatric autoimmune diseases; LUSC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg08499158 chr17:42289980 UBTF -0.5 -8.4 -0.42 1.33e-15 Total body bone mineral density; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg00745463 chr17:30367425 LRRC37B -0.8 -9.34 -0.46 1.36e-18 Hip circumference adjusted for BMI; LUSC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC cis rs4631830 0.720 rs11599333 chr10:51499655 A/C cg10326726 chr10:51549505 MSMB 0.34 5.87 0.31 1.03e-8 Prostate-specific antigen levels; LUSC cis rs9790314 0.818 rs6797066 chr3:161008725 T/A cg03342759 chr3:160939853 NMD3 -0.57 -9.84 -0.47 3.07e-20 Morning vs. evening chronotype; LUSC trans rs587847 0.507 rs10518956 chr15:37808780 A/G cg18296784 chr11:116147929 NA 0.34 6.04 0.31 4.22e-9 Intraocular pressure; LUSC trans rs11165623 0.564 rs9887887 chr1:96996930 A/G cg10631902 chr5:14652156 NA -0.41 -6.08 -0.32 3.24e-9 Hip circumference;Waist circumference; LUSC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg15448220 chr1:150897856 SETDB1 0.38 5.77 0.3 1.77e-8 Tonsillectomy; LUSC cis rs11809207 1.000 rs11247867 chr1:26517891 C/T cg00300879 chr1:26503847 CNKSR1 0.29 5.67 0.3 3.14e-8 Height; LUSC cis rs6460942 0.915 rs17324858 chr7:12305792 G/T cg06484146 chr7:12443880 VWDE -0.5 -6.16 -0.32 2.04e-9 Coronary artery disease; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg24060327 chr5:131705240 SLC22A5 -0.63 -10.78 -0.51 1.96e-23 Breast cancer; LUSC cis rs7100689 0.646 rs1953971 chr10:82145647 G/C cg01528321 chr10:82214614 TSPAN14 0.89 13.59 0.6 8.81e-34 Post bronchodilator FEV1; LUSC cis rs11690935 0.959 rs4667694 chr2:172605399 G/A cg13550731 chr2:172543902 DYNC1I2 -0.86 -14.07 -0.61 1.2e-35 Schizophrenia; LUSC cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.48 7.85 0.39 5.59e-14 IgG glycosylation; LUSC cis rs12295403 0.691 rs11607934 chr11:18689168 C/T cg09887367 chr11:18690185 NA -0.37 -7.35 -0.37 1.55e-12 Ovarian reserve; LUSC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg12564285 chr5:131593104 PDLIM4 0.33 5.83 0.3 1.3e-8 Breast cancer;Mosquito bite size; LUSC cis rs2290159 0.800 rs5746187 chr3:12659419 A/G cg23032965 chr3:12705835 RAF1 0.74 8.94 0.44 2.75e-17 Cholesterol, total; LUSC cis rs73206853 0.534 rs7131996 chr12:111073276 C/A cg12870014 chr12:110450643 ANKRD13A 0.7 7.69 0.39 1.67e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs27434 0.561 rs35134 chr5:96159523 A/G cg16492584 chr5:96139282 ERAP1 -0.56 -7.53 -0.38 4.91e-13 Ankylosing spondylitis; LUSC cis rs78545713 0.536 rs80202565 chr6:26233882 C/G cg23601095 chr6:26197514 HIST1H3D 0.7 6.1 0.32 2.96e-9 Iron status biomarkers (total iron binding capacity); LUSC cis rs8102476 0.905 rs7250689 chr19:38753625 C/T cg14131526 chr19:38747285 PPP1R14A 0.34 5.99 0.31 5.32e-9 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg22823121 chr1:150693482 HORMAD1 0.5 7.21 0.37 3.67e-12 Melanoma; LUSC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg17294928 chr15:75287854 SCAMP5 -0.93 -13.63 -0.6 6.13e-34 Blood trace element (Zn levels); LUSC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg21248554 chr2:27665150 KRTCAP3 0.3 6.01 0.31 4.81e-9 Total body bone mineral density; LUSC cis rs8017423 0.967 rs7147952 chr14:90720831 G/A cg04374321 chr14:90722782 PSMC1 0.75 12.11 0.55 3.01e-28 Mortality in heart failure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23132254 chr6:18264719 DEK -0.46 -6.91 -0.35 2.45e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg05347473 chr6:146136440 FBXO30 -0.66 -11.3 -0.53 2.81e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs12681288 0.712 rs2600488 chr8:1021266 A/C cg15309053 chr8:964076 NA 0.31 6.3 0.33 9.42e-10 Schizophrenia; LUSC cis rs8141529 0.584 rs58004020 chr22:29257050 A/T cg02153584 chr22:29168773 CCDC117 0.65 9.73 0.47 7.44e-20 Lymphocyte counts; LUSC cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg24812749 chr6:127587940 RNF146 0.92 13.86 0.6 7.98e-35 Breast cancer; LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg22166914 chr1:53195759 ZYG11B -0.61 -10.13 -0.48 3.41e-21 Monocyte count; LUSC cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.59 -0.43 3.42e-16 Body mass index; LUSC cis rs1559088 0.948 rs12460195 chr19:33584479 G/A cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.38e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg12463550 chr7:65579703 CRCP -0.49 -7.02 -0.36 1.24e-11 Aortic root size; LUSC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.93 0.4 3.34e-14 Parkinson's disease; LUSC trans rs1949829 0.826 rs6592923 chr7:51528494 C/T cg20941110 chr15:83953819 BNC1 0.55 6.01 0.31 4.98e-9 Wegener's granulomatosis; LUSC cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg02175503 chr12:58329896 NA 0.57 8.76 0.43 9.8e-17 Intelligence (multi-trait analysis); LUSC cis rs10927875 0.632 rs2013745 chr1:16126676 G/A cg21385522 chr1:16154831 NA -0.98 -18.12 -0.7 1.33e-51 Dilated cardiomyopathy; LUSC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg22105103 chr4:187893119 NA 0.74 14.28 0.62 1.91e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg10253484 chr15:75165896 SCAMP2 -0.47 -6.61 -0.34 1.52e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs10489202 0.608 rs4657733 chr1:168086434 G/A cg24449463 chr1:168025552 DCAF6 -0.66 -10.16 -0.49 2.67e-21 Schizophrenia; LUSC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg04800585 chr6:26043546 HIST1H2BB 0.43 6.13 0.32 2.47e-9 Intelligence (multi-trait analysis); LUSC cis rs1662342 1.000 rs12606445 chr18:3255700 C/T cg00760847 chr18:3262519 MYL12B -0.59 -5.81 -0.3 1.44e-8 QRS duration; LUSC cis rs9807989 0.507 rs2160201 chr2:103033961 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC cis rs7084921 0.608 rs12779818 chr10:101866118 G/A cg11888571 chr10:102027403 CWF19L1 -0.42 -5.84 -0.3 1.27e-8 Bone mineral density; LUSC cis rs782590 0.967 rs6545506 chr2:55798108 A/G cg03859395 chr2:55845619 SMEK2 -0.86 -16.21 -0.66 5.08e-44 Metabolic syndrome; LUSC trans rs13113376 0.912 rs1493224 chr4:131147580 A/G cg20030024 chr7:157442494 PTPRN2 0.39 6.05 0.31 3.81e-9 Intelligence; LUSC cis rs11711311 1.000 rs9809850 chr3:113429010 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.75 -0.3 1.99e-8 IgG glycosylation; LUSC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg18252515 chr7:66147081 NA -1.18 -12.98 -0.58 1.75e-31 Diabetic kidney disease; LUSC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg18240062 chr17:79603768 NPLOC4 -0.69 -12.85 -0.58 5.34e-31 Eye color traits; LUSC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg11366901 chr6:160182831 ACAT2 0.95 12.51 0.56 1.06e-29 Age-related macular degeneration (geographic atrophy); LUSC cis rs12421382 0.614 rs11213104 chr11:109391297 G/T cg27471124 chr11:109292789 C11orf87 0.36 6.45 0.33 3.83e-10 Schizophrenia; LUSC cis rs4704187 0.687 rs13359143 chr5:74433360 T/C cg03227963 chr5:74354835 NA 0.3 6.45 0.33 3.94e-10 Response to amphetamines; LUSC cis rs950169 0.887 rs12903946 chr15:84954430 T/C cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.64e-15 Schizophrenia; LUSC cis rs9921338 0.923 rs6498181 chr16:11427193 C/T cg00044050 chr16:11439710 C16orf75 -0.49 -6.56 -0.34 2.03e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg15073853 chr19:18549131 ISYNA1 -0.32 -5.83 -0.3 1.33e-8 Breast cancer; LUSC cis rs61990749 0.686 rs11159288 chr14:78216972 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.61 6.55 0.34 2.24e-10 Fibroblast growth factor basic levels; LUSC trans rs2018683 0.707 rs1021690 chr7:28974488 A/G cg19402173 chr7:128379420 CALU -0.47 -7.23 -0.37 3.36e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs4654899 0.802 rs10916906 chr1:21255675 C/A cg01072550 chr1:21505969 NA -0.53 -7.73 -0.39 1.32e-13 Superior frontal gyrus grey matter volume; LUSC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg20891283 chr12:69753455 YEATS4 0.62 9.13 0.45 6.58e-18 Response to diuretic therapy; LUSC cis rs7590368 0.961 rs13432104 chr2:10960661 T/C cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg08470875 chr2:26401718 FAM59B -0.65 -8.44 -0.42 9.82e-16 Gut microbiome composition (summer); LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.72 0.78 9.87e-70 Prudent dietary pattern; LUSC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.87 -0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7954584 0.611 rs3887885 chr12:122336486 C/T cg13699009 chr12:122356056 WDR66 0.48 7.56 0.38 3.87e-13 Mean corpuscular volume; LUSC cis rs17102423 0.651 rs2296316 chr14:65520246 A/G cg11161011 chr14:65562177 MAX -0.47 -7.15 -0.36 5.46e-12 Obesity-related traits; LUSC cis rs2797685 0.898 rs697693 chr1:7886424 C/T cg04725166 chr1:7887271 PER3 -0.46 -6.56 -0.34 1.99e-10 Crohn's disease; LUSC cis rs4363385 0.867 rs310103 chr1:153042554 C/A cg00922841 chr1:152955080 SPRR1A -0.46 -7.74 -0.39 1.21e-13 Inflammatory skin disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20548564 chr13:28240073 POLR1D -0.78 -6.18 -0.32 1.9e-9 Cognitive performance; LUSC cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg18681998 chr4:17616180 MED28 0.79 14.71 0.63 4.12e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg13647721 chr17:30228624 UTP6 0.59 6.0 0.31 5.22e-9 Hip circumference adjusted for BMI; LUSC cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg08085267 chr17:45401833 C17orf57 -0.54 -8.17 -0.41 6.34e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11997175 0.546 rs10808337 chr8:33583850 T/C ch.8.33884649F chr8:33765107 NA 0.47 7.43 0.38 8.95e-13 Body mass index; LUSC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg06212747 chr3:49208901 KLHDC8B 0.58 8.67 0.43 1.87e-16 Menarche (age at onset); LUSC cis rs6942756 0.774 rs891545 chr7:128866616 A/C cg02491457 chr7:128862824 NA 0.55 8.31 0.41 2.49e-15 White matter hyperintensity burden; LUSC cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg07606381 chr6:8435919 SLC35B3 -0.74 -12.38 -0.56 3.08e-29 Motion sickness; LUSC cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg21545522 chr1:205238299 TMCC2 0.51 9.59 0.46 2.16e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9300255 0.602 rs2682434 chr12:123694724 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs9467773 0.620 rs2451731 chr6:26624822 A/C cg11502198 chr6:26597334 ABT1 0.72 12.12 0.55 2.76e-28 Intelligence (multi-trait analysis); LUSC cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg21016266 chr12:122356598 WDR66 0.59 9.0 0.44 1.71e-17 Mean corpuscular volume; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg22166914 chr1:53195759 ZYG11B 0.61 10.06 0.48 5.73e-21 Monocyte count; LUSC cis rs877282 0.853 rs12763400 chr10:763617 C/T cg17470449 chr10:769945 NA 0.52 7.08 0.36 8.38e-12 Uric acid levels; LUSC cis rs11168618 0.567 rs7314569 chr12:48816981 G/T cg24011408 chr12:48396354 COL2A1 0.41 6.45 0.33 3.88e-10 Adiponectin levels; LUSC trans rs208520 0.742 rs208454 chr6:66907783 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.96 -12.9 -0.58 3.55e-31 Exhaled nitric oxide output; LUSC cis rs1018836 0.545 rs7840203 chr8:91701223 A/G cg16814680 chr8:91681699 NA -1.08 -24.55 -0.8 8.68e-77 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs77216612 0.840 rs11055030 chr12:12878349 G/C cg09462578 chr12:12878428 APOLD1 -1.0 -17.14 -0.68 1.1e-47 Lymphocyte counts; LUSC trans rs11098499 0.954 rs7656252 chr4:120404268 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 4.01e-10 Corneal astigmatism; LUSC cis rs7569084 0.522 rs906577 chr2:65596657 A/G cg08085232 chr2:65598271 SPRED2 -0.43 -6.76 -0.35 6.04e-11 Sum eosinophil basophil counts; LUSC cis rs7512552 0.839 rs3820544 chr1:150457876 A/T cg15654264 chr1:150340011 RPRD2 0.62 10.31 0.49 8.23e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7091068 0.522 rs10882323 chr10:95483280 T/C cg20715218 chr10:95462985 C10orf4 0.6 7.32 0.37 1.86e-12 Urinary tract infection frequency; LUSC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg08219700 chr8:58056026 NA 0.69 8.02 0.4 1.79e-14 Developmental language disorder (linguistic errors); LUSC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg20476274 chr7:133979776 SLC35B4 0.82 14.95 0.63 4.64e-39 Mean platelet volume; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg22907277 chr7:1156413 C7orf50 0.48 7.19 0.37 4.25e-12 Longevity;Endometriosis; LUSC cis rs11039100 0.850 rs34037040 chr11:5834673 G/A cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12210905 0.841 rs116485609 chr6:26864205 T/C cg23155468 chr6:27110703 HIST1H2BK -0.64 -5.66 -0.3 3.25e-8 Hip circumference adjusted for BMI; LUSC cis rs8072100 0.967 rs11656855 chr17:45714655 C/T cg25173405 chr17:45401733 C17orf57 0.37 5.92 0.31 7.98e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg06112835 chr11:68658793 MRPL21 0.49 7.4 0.38 1.14e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs477692 0.789 rs507900 chr10:131398144 A/G cg26102564 chr10:131424627 MGMT -0.46 -7.17 -0.37 4.97e-12 Response to temozolomide; LUSC cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg00631329 chr6:26305371 NA 0.45 8.78 0.43 8.68e-17 Educational attainment; LUSC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg03806693 chr22:41940476 POLR3H -0.88 -10.92 -0.51 5.92e-24 Vitiligo; LUSC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs412000 0.507 rs2680688 chr17:56450524 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.37 -5.79 -0.3 1.6e-8 Primary tooth development (time to first tooth eruption); LUSC cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg08807101 chr21:30365312 RNF160 -0.54 -8.2 -0.41 5.09e-15 Dental caries; LUSC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.84 12.63 0.57 3.83e-30 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12681287 0.640 rs13253261 chr8:87458500 T/C cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs483180 0.511 rs496198 chr1:120207177 A/G cg19096424 chr1:120255104 PHGDH -0.48 -6.7 -0.34 8.67e-11 Macular telangiectasia type 2; LUSC cis rs77633900 0.772 rs2956873 chr15:76695305 G/A cg21673338 chr15:77095150 SCAPER -0.72 -6.16 -0.32 2.14e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs727505 1.000 rs10241173 chr7:124453258 A/G cg23710748 chr7:124431027 NA -0.41 -7.32 -0.37 1.88e-12 Lewy body disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg24094374 chr14:81685932 GTF2A1 0.76 6.34 0.33 7.27e-10 Cognitive performance; LUSC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg13206674 chr6:150067644 NUP43 0.6 9.37 0.46 1.12e-18 Lung cancer; LUSC cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg13256891 chr4:100009986 ADH5 0.43 6.03 0.31 4.38e-9 Alcohol dependence; LUSC cis rs11031096 0.678 rs2044135 chr11:4187233 G/A cg18678763 chr11:4115507 RRM1 -0.43 -6.04 -0.31 4.15e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs61931739 0.500 rs7489130 chr12:34539674 C/A cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs11190604 1.000 rs74210981 chr10:102287520 C/T cg07080220 chr10:102295463 HIF1AN 0.69 8.84 0.44 5.4e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg15017067 chr4:17643749 FAM184B 0.34 5.72 0.3 2.33e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC cis rs7707921 0.958 rs6452447 chr5:81482522 A/G cg15871215 chr5:81402204 ATG10 0.44 6.32 0.33 8.43e-10 Breast cancer; LUSC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 5.89 0.31 9.6e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7539542 0.556 rs4950889 chr1:202874786 T/C cg19681188 chr1:202830198 LOC148709 0.39 5.77 0.3 1.86e-8 Mean platelet volume; LUSC cis rs6951245 0.678 rs4724725 chr7:1214751 G/A cg22907277 chr7:1156413 C7orf50 0.64 6.68 0.34 1.02e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9788682 0.747 rs2958719 chr15:78743029 G/A cg06917634 chr15:78832804 PSMA4 0.48 6.02 0.31 4.61e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7020830 0.825 rs10973248 chr9:37197768 C/T cg14294708 chr9:37120828 ZCCHC7 1.09 25.55 0.81 1.45e-80 Schizophrenia; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg11965913 chr1:205819406 PM20D1 0.83 15.46 0.65 4.81e-41 Menarche (age at onset); LUSC cis rs34779708 0.931 rs68039650 chr10:35385499 C/A cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs476633 0.691 rs11858115 chr15:41542591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.49 -8.72 -0.43 1.35e-16 Glomerular filtration rate (creatinine); LUSC cis rs3892630 0.878 rs114224536 chr19:33211232 A/G cg22980127 chr19:33182716 NUDT19 0.93 12.44 0.56 1.88e-29 Red blood cell traits; LUSC cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg15839431 chr19:19639596 YJEFN3 -0.67 -7.34 -0.37 1.62e-12 Bipolar disorder; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg13397359 chr6:42928475 GNMT 0.65 10.85 0.51 1.04e-23 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs13067593 1.000 rs35300952 chr3:188572797 A/G cg17809494 chr3:188572244 LPP 0.42 5.73 0.3 2.22e-8 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg04944784 chr2:26401820 FAM59B 0.77 11.41 0.53 1.12e-25 Gut microbiome composition (summer); LUSC cis rs7043114 0.525 rs10739927 chr9:95052081 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.46 -0.33 3.63e-10 Height; LUSC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg09796270 chr17:17721594 SREBF1 0.42 7.51 0.38 5.43e-13 Total body bone mineral density; LUSC cis rs6681460 1.000 rs6656550 chr1:67122552 C/T cg02459107 chr1:67143332 SGIP1 0.48 9.0 0.44 1.73e-17 Presence of antiphospholipid antibodies; LUSC trans rs62055045 0.528 rs62056195 chr16:71549485 A/G cg21834679 chr15:96891026 NA -0.43 -6.67 -0.34 1.04e-10 Schizophrenia; LUSC cis rs4423214 1.000 rs11600569 chr11:71173747 C/G cg05163923 chr11:71159392 DHCR7 0.75 11.19 0.52 6.83e-25 Vitamin D levels; LUSC cis rs9325144 0.600 rs12424410 chr12:38758035 A/T cg26384229 chr12:38710491 ALG10B -0.6 -9.23 -0.45 3.16e-18 Morning vs. evening chronotype; LUSC cis rs7119 0.717 rs12912386 chr15:77817640 T/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs4654899 0.680 rs4654879 chr1:21186378 G/A cg01072550 chr1:21505969 NA 0.48 7.39 0.37 1.21e-12 Superior frontal gyrus grey matter volume; LUSC cis rs77106637 1.000 rs11605166 chr11:72669777 T/C cg03713592 chr11:72463424 ARAP1 0.86 10.13 0.48 3.27e-21 Type 2 diabetes; LUSC cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg17366294 chr4:99064904 C4orf37 0.61 10.78 0.51 1.87e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.534 rs9355610 chr6:167383075 G/A cg23791538 chr6:167370224 RNASET2 0.52 8.74 0.43 1.15e-16 Crohn's disease; LUSC cis rs9318086 0.712 rs12875437 chr13:24453956 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.42 6.39 0.33 5.54e-10 Myopia (pathological); LUSC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15506890 chr2:3487001 NA -0.58 -9.66 -0.47 1.27e-19 Neurofibrillary tangles; LUSC cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg09526685 chr4:187126073 CYP4V2 0.62 6.09 0.32 3.13e-9 Activated partial thromboplastin time; LUSC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg15147215 chr3:52552868 STAB1 -0.3 -5.82 -0.3 1.36e-8 Intelligence (multi-trait analysis); LUSC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg12826209 chr6:26865740 GUSBL1 0.67 9.27 0.45 2.35e-18 Intelligence (multi-trait analysis); LUSC cis rs983392 0.678 rs4938933 chr11:60034429 C/T cg20284999 chr11:59952153 MS4A6A 0.38 6.48 0.33 3.19e-10 Alzheimer's disease (late onset); LUSC cis rs6430585 0.528 rs309161 chr2:136688749 A/G cg07169764 chr2:136633963 MCM6 -1.01 -15.25 -0.64 3.13e-40 Corneal structure; LUSC cis rs2303282 0.933 rs7198524 chr16:56510601 C/T cg00500540 chr16:56394104 NA -0.44 -7.04 -0.36 1.09e-11 Breast cancer; LUSC cis rs3126085 0.935 rs1390488 chr1:152199500 T/C cg26876637 chr1:152193138 HRNR 0.45 6.22 0.32 1.47e-9 Atopic dermatitis; LUSC cis rs4363385 0.693 rs490553 chr1:153033277 A/G cg00922841 chr1:152955080 SPRR1A -0.42 -7.28 -0.37 2.39e-12 Inflammatory skin disease; LUSC cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg05985134 chr18:33552581 C18orf21 0.52 7.21 0.37 3.66e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs62458065 0.513 rs7788809 chr7:32552622 T/A cg20159608 chr7:32802032 NA -0.68 -8.68 -0.43 1.77e-16 Metabolite levels (HVA/MHPG ratio); LUSC cis rs1577917 0.655 rs2842605 chr6:86335150 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -7.22 -0.37 3.55e-12 Response to antipsychotic treatment; LUSC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.11 0.52 1.27e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg04998671 chr14:104000505 TRMT61A -0.42 -6.22 -0.32 1.51e-9 Reticulocyte count; LUSC cis rs1775715 0.870 rs7912121 chr10:32228995 T/G cg26784012 chr10:32216390 ARHGAP12 0.41 6.9 0.35 2.59e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3755132 1.000 rs3755132 chr2:15729820 T/G cg12888861 chr2:15731646 DDX1 0.51 7.32 0.37 1.81e-12 Wilms tumor; LUSC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs858239 0.601 rs4440529 chr7:23168751 G/C cg23682824 chr7:23144976 KLHL7 0.41 5.86 0.31 1.13e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7100689 0.646 rs7903701 chr10:82129268 T/C cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -7.55 -0.38 4.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg22437258 chr11:111473054 SIK2 0.5 6.94 0.36 2.04e-11 Primary sclerosing cholangitis; LUSC trans rs10492201 0.529 rs4913390 chr12:68387476 C/T cg21566642 chr2:233284661 NA -0.39 -6.03 -0.31 4.28e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs28647808 0.881 rs41316982 chr9:136259117 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg03806693 chr22:41940476 POLR3H -0.98 -13.17 -0.58 3.39e-32 Vitiligo; LUSC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg18230493 chr5:56204884 C5orf35 0.58 8.88 0.44 4.15e-17 Type 2 diabetes; LUSC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg00546932 chr16:1947055 NA -0.38 -5.67 -0.3 3.17e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs2286885 1.000 rs10733679 chr9:129242416 C/T cg15282417 chr9:129245246 FAM125B 0.35 5.93 0.31 7.38e-9 Intraocular pressure; LUSC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.09 0.52 1.58e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs2629540 0.824 rs1552345 chr10:126477406 A/G cg08799069 chr10:126477246 METTL10 -0.72 -11.11 -0.52 1.34e-24 Cocaine dependence; LUSC cis rs929354 0.557 rs62491947 chr7:156960813 G/A cg17757837 chr7:157058334 UBE3C 0.82 13.03 0.58 1.18e-31 Body mass index; LUSC cis rs7940866 0.845 rs1433976 chr11:130875123 C/T cg12179176 chr11:130786555 SNX19 -0.64 -10.08 -0.48 4.94e-21 Schizophrenia; LUSC cis rs7412746 0.611 rs2228099 chr1:150808889 C/G cg04414720 chr1:150670196 GOLPH3L 0.48 7.76 0.39 1.02e-13 Melanoma; LUSC cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg08999081 chr20:33150536 PIGU -0.53 -10.52 -0.5 1.51e-22 Glomerular filtration rate (creatinine); LUSC cis rs4808199 0.895 rs4808196 chr19:19476520 G/A cg03709012 chr19:19516395 GATAD2A 1.11 13.8 0.6 1.37e-34 Nonalcoholic fatty liver disease; LUSC cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg27129171 chr3:47204927 SETD2 -0.68 -10.95 -0.51 4.63e-24 Colorectal cancer; LUSC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg26566898 chr11:117069891 TAGLN 0.49 8.07 0.4 1.3e-14 Blood protein levels; LUSC cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg18681998 chr4:17616180 MED28 0.86 15.73 0.65 4.21e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs9929218 0.954 rs72785165 chr16:68755635 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -11.8 -0.54 4.28e-27 Colorectal cancer; LUSC cis rs870825 0.550 rs28525282 chr4:185631468 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.12 0.58 5.24e-32 Blood protein levels; LUSC cis rs4285028 0.948 rs35737776 chr3:121677856 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.63 -0.47 1.55e-19 Multiple sclerosis; LUSC trans rs656319 0.674 rs1484639 chr8:9983224 T/G cg21775007 chr8:11205619 TDH 0.45 6.34 0.33 7.5e-10 Myopia (pathological); LUSC cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.65 0.5 5.24e-23 Heart rate; LUSC cis rs4343996 0.905 rs10233166 chr7:3343382 A/G cg21248987 chr7:3385318 SDK1 0.41 6.93 0.35 2.21e-11 Motion sickness; LUSC cis rs922692 0.773 rs2904220 chr15:79076704 G/T cg00540400 chr15:79124168 NA -0.41 -7.06 -0.36 9.95e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -6.1 -0.32 2.9e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9372253 0.843 rs9386895 chr6:110719632 T/A cg00083206 chr6:110721305 DDO -0.46 -8.42 -0.42 1.1e-15 Platelet distribution width; LUSC cis rs9325144 0.650 rs6582624 chr12:38733475 A/T cg13010199 chr12:38710504 ALG10B -0.45 -6.86 -0.35 3.42e-11 Morning vs. evening chronotype; LUSC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.63 9.62 0.47 1.65e-19 Height; LUSC cis rs516243 0.806 rs7545228 chr1:10740303 G/C cg02903756 chr1:10750680 CASZ1 -0.5 -8.78 -0.43 8.63e-17 Migraine - clinic-based; LUSC cis rs7829975 0.681 rs2271342 chr8:8643938 C/T cg14343924 chr8:8086146 FLJ10661 0.45 6.3 0.33 9.64e-10 Mood instability; LUSC cis rs17336368 1.000 rs17336368 chr6:44751668 G/A cg18551225 chr6:44695536 NA -0.49 -8.42 -0.42 1.14e-15 Chin dimples; LUSC trans rs1994135 0.617 rs10743824 chr12:33733764 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.19 0.37 4.27e-12 Resting heart rate; LUSC cis rs7777754 0.512 rs7785224 chr7:50562361 T/C cg18232548 chr7:50535776 DDC -0.7 -11.03 -0.52 2.54e-24 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg26513180 chr16:89883248 FANCA -0.58 -8.92 -0.44 3.14e-17 Vitiligo; LUSC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg12292205 chr6:26970375 C6orf41 -0.59 -7.58 -0.38 3.39e-13 Intelligence (multi-trait analysis); LUSC cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg13256891 chr4:100009986 ADH5 -0.44 -6.07 -0.32 3.55e-9 Alcohol dependence; LUSC cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg03060546 chr3:49711283 APEH 0.67 7.79 0.39 8.37e-14 Menarche (age at onset); LUSC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg15744005 chr10:104629667 AS3MT -0.39 -7.94 -0.4 3.02e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6964587 1.000 rs13245393 chr7:91641928 A/G cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.08e-8 Breast cancer; LUSC trans rs12571093 0.803 rs17297418 chr10:70031651 A/G cg04882175 chr6:131122610 NA 0.56 6.51 0.34 2.75e-10 Optic nerve measurement (disc area); LUSC cis rs634534 0.622 rs1308733 chr11:65720841 T/C cg26695010 chr11:65641043 EFEMP2 0.54 8.03 0.4 1.64e-14 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs4243830 0.850 rs10864612 chr1:6593830 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -10.33 -0.49 6.89e-22 Body mass index; LUSC cis rs6750047 0.719 rs100489 chr2:38266478 T/C cg07380506 chr2:38303506 CYP1B1 -0.44 -5.98 -0.31 5.79e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs7215564 0.908 rs36077104 chr17:78661757 T/A cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC trans rs9951602 0.512 rs4799249 chr18:76654370 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs2625529 0.526 rs1035744 chr15:72566615 C/T cg16672083 chr15:72433130 SENP8 0.46 7.48 0.38 6.56e-13 Red blood cell count; LUSC cis rs10979 0.597 rs9496684 chr6:143908687 C/A cg25407410 chr6:143891975 LOC285740 -0.65 -8.17 -0.41 6.6e-15 Hypospadias; LUSC cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg11584989 chr19:19387371 SF4 0.59 7.01 0.36 1.33e-11 Bipolar disorder; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg20913137 chr8:145691627 CYHR1;KIFC2 0.37 6.26 0.32 1.16e-9 Metabolite levels (Pyroglutamine); LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg02018176 chr4:1364513 KIAA1530 -0.57 -9.85 -0.47 2.92e-20 Obesity-related traits; LUSC cis rs9303401 0.659 rs2072316 chr17:56604813 G/T cg25039879 chr17:56429692 SUPT4H1 0.69 9.17 0.45 5.1e-18 Cognitive test performance; LUSC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.66 0.34 1.11e-10 Lung cancer; LUSC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.43 0.46 7.11e-19 Hip circumference adjusted for BMI; LUSC trans rs7824557 0.606 rs2736270 chr8:11192593 G/A cg06636001 chr8:8085503 FLJ10661 0.54 7.83 0.39 6.49e-14 Retinal vascular caliber; LUSC cis rs12310956 0.532 rs35366144 chr12:33992000 C/G cg06521331 chr12:34319734 NA -0.46 -7.33 -0.37 1.72e-12 Morning vs. evening chronotype; LUSC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg15704280 chr7:45808275 SEPT13 -1.04 -18.08 -0.7 2.04e-51 Coronary artery disease; LUSC cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.38 -6.98 -0.36 1.58e-11 Monocyte percentage of white cells; LUSC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.46e-20 Hip circumference adjusted for BMI; LUSC cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg24642439 chr20:33292090 TP53INP2 0.69 11.13 0.52 1.13e-24 Coronary artery disease; LUSC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7582180 0.606 rs10174145 chr2:100932488 T/C cg12002119 chr2:101014098 CHST10 0.36 5.94 0.31 7.26e-9 Intelligence (multi-trait analysis); LUSC cis rs4851254 0.961 rs13022707 chr2:100734946 C/A cg07810366 chr2:100720526 AFF3 -0.38 -5.97 -0.31 6.21e-9 Intelligence (multi-trait analysis); LUSC cis rs77633900 0.772 rs2957611 chr15:76704878 C/T cg21673338 chr15:77095150 SCAPER -0.7 -5.99 -0.31 5.4e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs61931739 0.500 rs10844848 chr12:34409705 A/C cg06521331 chr12:34319734 NA -0.4 -6.27 -0.32 1.11e-9 Morning vs. evening chronotype; LUSC cis rs2197308 0.619 rs4002730 chr12:37876400 T/C cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC trans rs61931739 0.746 rs1687003 chr12:34170099 T/A cg26384229 chr12:38710491 ALG10B 0.55 8.81 0.43 7.02e-17 Morning vs. evening chronotype; LUSC cis rs8114671 0.562 rs6088647 chr20:33505997 T/C cg24642439 chr20:33292090 TP53INP2 0.45 6.48 0.33 3.38e-10 Height; LUSC cis rs2282032 0.883 rs10143036 chr14:90774914 T/G cg14092571 chr14:90743983 NA 0.48 6.23 0.32 1.43e-9 Longevity; LUSC cis rs793571 0.522 rs11071398 chr15:59120077 A/G cg05156742 chr15:59063176 FAM63B 0.55 8.51 0.42 6.11e-16 Schizophrenia; LUSC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg00166722 chr3:10149974 C3orf24 -0.38 -5.66 -0.3 3.3e-8 Alzheimer's disease; LUSC cis rs1371867 0.846 rs1660351 chr8:101275034 C/T cg06002616 chr8:101225028 SPAG1 -0.43 -7.09 -0.36 8.24e-12 Atrioventricular conduction; LUSC cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.52 10.29 0.49 9.47e-22 Hemoglobin concentration; LUSC trans rs11098499 0.754 rs10518300 chr4:120249499 G/T cg25214090 chr10:38739885 LOC399744 -0.42 -6.18 -0.32 1.92e-9 Corneal astigmatism; LUSC cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.51 -6.77 -0.35 5.75e-11 Tonsillectomy; LUSC cis rs1372520 0.684 rs2619356 chr4:90750844 C/T cg15133208 chr4:90757351 SNCA -0.53 -8.16 -0.41 6.98e-15 Neuroticism; LUSC cis rs9815354 0.812 rs73069208 chr3:41939198 C/T cg03022575 chr3:42003672 ULK4 0.83 8.64 0.43 2.32e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs360798 0.512 rs7562149 chr2:63008414 A/G cg17519650 chr2:63277830 OTX1 -0.48 -6.85 -0.35 3.63e-11 Coronary artery disease; LUSC cis rs10435719 0.902 rs7459545 chr8:11804389 G/T cg21775007 chr8:11205619 TDH 0.46 6.68 0.34 9.8e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7804356 0.906 rs3801828 chr7:26855284 C/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.39 -0.46 9.83e-19 Schizophrenia; LUSC cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg05347473 chr6:146136440 FBXO30 0.48 7.85 0.39 5.78e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6693567 0.565 rs1694379 chr1:150292417 C/A cg15654264 chr1:150340011 RPRD2 0.45 7.25 0.37 2.89e-12 Migraine; LUSC cis rs10992471 0.639 rs10125587 chr9:95499882 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -6.84 -0.35 3.73e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2075671 0.903 rs11973874 chr7:100263272 T/C cg20848291 chr7:100343083 ZAN -0.59 -7.99 -0.4 2.26e-14 Other erythrocyte phenotypes; LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg13560548 chr3:10150139 C3orf24 0.5 7.05 0.36 1.01e-11 Alzheimer's disease; LUSC cis rs9430161 0.579 rs7542354 chr1:11040385 G/A cg02454025 chr1:11042201 C1orf127 0.91 16.95 0.68 6.13e-47 Ewing sarcoma; LUSC cis rs9420 0.961 rs71484461 chr11:57488890 G/A cg02958346 chr11:57425731 CLP1 -0.43 -6.28 -0.32 1.06e-9 Schizophrenia; LUSC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg25124228 chr12:125621409 AACS -0.41 -5.68 -0.3 2.97e-8 Post bronchodilator FEV1/FVC ratio; LUSC trans rs7819412 0.875 rs6981523 chr8:11061792 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -6.74 -0.35 6.76e-11 Triglycerides; LUSC cis rs208520 1.000 rs28773210 chr6:66993566 C/T cg07460842 chr6:66804631 NA 0.93 12.09 0.55 3.65e-28 Exhaled nitric oxide output; LUSC trans rs11098499 1.000 rs7659194 chr4:120207147 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.43 5.99 0.31 5.48e-9 Corneal astigmatism; LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg16145915 chr7:1198662 ZFAND2A -0.47 -8.46 -0.42 8.68e-16 Longevity;Endometriosis; LUSC cis rs9733 0.744 rs12126004 chr1:150889877 T/C cg04414720 chr1:150670196 GOLPH3L -0.44 -6.89 -0.35 2.85e-11 Tonsillectomy; LUSC cis rs67478160 0.634 rs2024669 chr14:104275602 G/C cg08213375 chr14:104286397 PPP1R13B 0.45 8.68 0.43 1.8e-16 Schizophrenia; LUSC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg02772935 chr3:125709198 NA -0.48 -5.78 -0.3 1.67e-8 Blood pressure (smoking interaction); LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg20607798 chr8:58055168 NA 0.5 5.96 0.31 6.57e-9 Developmental language disorder (linguistic errors); LUSC cis rs7246967 0.673 rs4933026 chr19:22874492 A/T cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs7829975 0.684 rs474892 chr8:8596731 G/T cg15556689 chr8:8085844 FLJ10661 -0.56 -8.34 -0.42 2.02e-15 Mood instability; LUSC cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg06022373 chr22:39101656 GTPBP1 0.78 12.29 0.56 6.96e-29 Menopause (age at onset); LUSC cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg22590775 chr19:49891494 CCDC155 -0.48 -6.67 -0.34 1.05e-10 Multiple sclerosis; LUSC cis rs6964587 0.869 rs406 chr7:91546526 C/A cg22709100 chr7:91322751 NA -0.39 -5.76 -0.3 1.89e-8 Breast cancer; LUSC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg00033643 chr7:134001901 SLC35B4 0.44 6.64 0.34 1.27e-10 Mean platelet volume; LUSC cis rs634534 0.563 rs470192 chr11:65724291 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.49 7.35 0.37 1.51e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs10435719 0.902 rs7006538 chr8:11804982 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.71 0.34 8.33e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs877282 0.629 rs78997110 chr10:764388 A/G cg17470449 chr10:769945 NA 0.52 6.81 0.35 4.47e-11 Uric acid levels; LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg11843238 chr5:131593191 PDLIM4 0.39 6.54 0.34 2.28e-10 Breast cancer; LUSC cis rs7605827 0.634 rs13416086 chr2:15688107 T/C cg19274914 chr2:15703543 NA -0.45 -8.05 -0.4 1.43e-14 Educational attainment (years of education); LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.72 11.08 0.52 1.64e-24 Lymphocyte counts; LUSC cis rs4704187 0.687 rs4340901 chr5:74404905 C/T cg03227963 chr5:74354835 NA 0.33 7.1 0.36 7.73e-12 Response to amphetamines; LUSC cis rs4295623 0.531 rs2898295 chr8:11595969 C/T cg00262122 chr8:11665843 FDFT1 -0.44 -6.66 -0.34 1.13e-10 Morning vs. evening chronotype; LUSC trans rs7937682 0.889 rs10789844 chr11:111579109 A/T cg18187862 chr3:45730750 SACM1L 0.58 7.55 0.38 4.07e-13 Primary sclerosing cholangitis; LUSC cis rs447735 0.587 rs258336 chr16:89720831 A/C cg01097406 chr16:89675127 NA 0.35 6.96 0.36 1.77e-11 Hemoglobin concentration; LUSC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.53 0.6 1.46e-33 Platelet count; LUSC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg13395646 chr4:1353034 KIAA1530 -0.58 -9.16 -0.45 5.38e-18 Longevity; LUSC cis rs10752881 0.775 rs2147585 chr1:183074875 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.81 0.51 1.45e-23 Colorectal cancer; LUSC cis rs113835537 0.529 rs57207756 chr11:66270360 C/T cg24851651 chr11:66362959 CCS 0.53 7.71 0.39 1.47e-13 Airway imaging phenotypes; LUSC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg12751644 chr20:60527061 NA -0.33 -5.89 -0.31 9.2e-9 Body mass index; LUSC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg05861140 chr6:150128134 PCMT1 -0.39 -6.22 -0.32 1.52e-9 Lung cancer; LUSC cis rs1570884 0.516 rs9316463 chr13:50176844 G/A cg03651054 chr13:50194643 NA 0.36 6.23 0.32 1.38e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg26314531 chr2:26401878 FAM59B 0.74 10.06 0.48 5.92e-21 Gut microbiome composition (summer); LUSC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg03036452 chr22:46663545 TTC38 0.57 5.79 0.3 1.63e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.37 0.53 1.47e-25 Prudent dietary pattern; LUSC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg13628971 chr7:2884303 GNA12 0.48 6.69 0.34 9.15e-11 Height; LUSC cis rs9303401 0.659 rs34275691 chr17:56736640 A/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.67 0.43 1.92e-16 Cognitive test performance; LUSC cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg08999081 chr20:33150536 PIGU 0.43 8.01 0.4 1.92e-14 Coronary artery disease; LUSC cis rs6960043 0.818 rs10228796 chr7:15064190 C/G cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC cis rs61931739 0.513 rs2200555 chr12:33899381 C/G cg06521331 chr12:34319734 NA -0.35 -5.7 -0.3 2.61e-8 Morning vs. evening chronotype; LUSC cis rs1971762 0.563 rs10219725 chr12:54080865 T/G cg23533419 chr12:54090519 NA -0.38 -6.2 -0.32 1.64e-9 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12679980 chr5:43557583 PAIP1 -0.47 -6.09 -0.32 3.05e-9 Bipolar disorder and schizophrenia; LUSC trans rs6601327 0.585 rs11249934 chr8:9510830 C/T cg15556689 chr8:8085844 FLJ10661 0.46 6.49 0.33 3.04e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.58e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4853525 0.522 rs62179717 chr2:191590813 T/G cg11845111 chr2:191398756 TMEM194B -0.43 -5.78 -0.3 1.75e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs1670533 1.000 rs629261 chr4:1086763 A/C cg27284194 chr4:1044797 NA 0.6 9.01 0.44 1.61e-17 Recombination rate (females); LUSC cis rs7512552 0.966 rs1122967 chr1:150258838 C/G cg15654264 chr1:150340011 RPRD2 -0.61 -10.05 -0.48 6e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg24549020 chr5:56110836 MAP3K1 -0.44 -5.87 -0.31 1.04e-8 Initial pursuit acceleration; LUSC cis rs9457247 0.582 rs9459855 chr6:167466150 G/T cg06454157 chr6:167490870 NA -0.3 -7.03 -0.36 1.19e-11 Crohn's disease; LUSC cis rs9837602 1.000 rs6790535 chr3:99807735 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.31 0.33 8.83e-10 Breast cancer; LUSC trans rs11039798 1.000 rs7942042 chr11:48520270 A/G cg03929089 chr4:120376271 NA 0.65 6.07 0.32 3.39e-9 Axial length; LUSC cis rs72781680 0.716 rs6731314 chr2:24048338 C/T cg08917208 chr2:24149416 ATAD2B -0.6 -6.89 -0.35 2.84e-11 Lymphocyte counts; LUSC cis rs1832871 0.630 rs11754501 chr6:158710451 A/G cg07165851 chr6:158734300 TULP4 0.45 6.9 0.35 2.66e-11 Height; LUSC cis rs113835537 0.529 rs7928882 chr11:66234765 C/T cg24851651 chr11:66362959 CCS 0.54 8.27 0.41 3.33e-15 Airway imaging phenotypes; LUSC cis rs7000551 0.689 rs6997299 chr8:22324268 T/C cg12081754 chr8:22256438 SLC39A14 0.46 6.91 0.35 2.48e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg02428538 chr16:24856791 SLC5A11 -0.6 -6.75 -0.35 6.4e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg21016266 chr12:122356598 WDR66 0.63 9.43 0.46 7.11e-19 Mean corpuscular volume; LUSC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.74 0.3 2.13e-8 Personality dimensions; LUSC cis rs829883 0.621 rs11109516 chr12:98921035 G/A cg25150519 chr12:98850993 NA -0.63 -8.64 -0.43 2.36e-16 Colorectal adenoma (advanced); LUSC cis rs6496667 0.510 rs7495784 chr15:91068882 T/C cg10434728 chr15:90938212 IQGAP1 -0.35 -6.44 -0.33 4.15e-10 Rheumatoid arthritis; LUSC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs11792861 0.890 rs57387569 chr9:111920392 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 8.63 0.43 2.59e-16 Menarche (age at onset); LUSC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg08859206 chr1:53392774 SCP2 0.46 7.68 0.39 1.78e-13 Monocyte count; LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg13047869 chr3:10149882 C3orf24 0.59 8.52 0.42 5.61e-16 Alzheimer's disease; LUSC cis rs7666738 0.546 rs10025064 chr4:98914060 A/G cg03676636 chr4:99064102 C4orf37 0.3 6.11 0.32 2.75e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.94 0.48 1.4e-20 Bipolar disorder; LUSC trans rs7615952 0.866 rs13063119 chr3:125643847 G/A cg07211511 chr3:129823064 LOC729375 -1.22 -20.76 -0.75 4.52e-62 Blood pressure (smoking interaction); LUSC cis rs1891275 0.515 rs10786010 chr10:93443773 G/A cg07889827 chr10:93443413 NA -0.38 -8.55 -0.42 4.34e-16 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.71 0.51 3.33e-23 Monocyte percentage of white cells; LUSC cis rs10911251 0.546 rs1547715 chr1:183113952 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16584020 chr19:3573832 HMG20B -0.46 -5.98 -0.31 5.8e-9 Bipolar disorder and schizophrenia; LUSC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg10018233 chr7:150070692 REPIN1 -0.4 -6.67 -0.34 1.05e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs9467711 0.559 rs9393727 chr6:26500011 C/G cg09904177 chr6:26538194 HMGN4 -0.7 -6.4 -0.33 5.27e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs12893597 0.821 rs12896434 chr14:76816746 C/T cg20290672 chr14:76816747 NA -0.32 -5.64 -0.3 3.57e-8 Maximal oxygen uptake response; LUSC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg26513180 chr16:89883248 FANCA 0.91 17.76 0.7 3.84e-50 Vitiligo; LUSC cis rs2797160 1.000 rs4897152 chr6:126002400 A/G cg05901451 chr6:126070800 HEY2 -0.57 -8.56 -0.42 4.29e-16 Endometrial cancer; LUSC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.846 rs1854901 chr6:146325685 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.05 -0.36 1.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg06634786 chr22:41940651 POLR3H -0.55 -6.44 -0.33 4.06e-10 Vitiligo; LUSC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg14582100 chr15:45693742 SPATA5L1 0.55 9.61 0.47 1.85e-19 Homoarginine levels; LUSC cis rs977987 0.778 rs4888413 chr16:75443223 C/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.61 -0.34 1.52e-10 Dupuytren's disease; LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18404041 chr3:52824283 ITIH1 -0.59 -11.67 -0.54 1.26e-26 Bipolar disorder; LUSC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg24562669 chr7:97807699 LMTK2 0.34 6.06 0.31 3.74e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg11062466 chr8:58055876 NA 0.5 6.06 0.31 3.61e-9 Developmental language disorder (linguistic errors); LUSC cis rs1018697 0.518 rs2482506 chr10:104563743 C/G cg04362960 chr10:104952993 NT5C2 -0.68 -8.51 -0.42 6.09e-16 Colorectal adenoma (advanced); LUSC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg03806693 chr22:41940476 POLR3H -0.97 -14.26 -0.62 2.33e-36 Vitiligo; LUSC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.43 -5.83 -0.3 1.33e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs71435601 0.657 rs67599264 chr2:21418083 G/A cg20757404 chr19:378427 NA -0.42 -6.33 -0.33 7.97e-10 Cholesterol, total; LUSC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg03115019 chr17:80708279 FN3K -0.44 -7.02 -0.36 1.22e-11 Glycated hemoglobin levels; LUSC cis rs2067615 0.599 rs3759310 chr12:107166122 C/G cg15890332 chr12:107067104 RFX4 0.34 6.35 0.33 7.22e-10 Heart rate; LUSC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg12257692 chr3:49977190 RBM6 -0.26 -7.32 -0.37 1.82e-12 Body mass index; LUSC cis rs4595586 0.545 rs12821810 chr12:39375858 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg08754478 chr10:133766260 PPP2R2D -0.63 -8.13 -0.41 8.49e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg17173187 chr15:85201210 NMB -0.31 -6.35 -0.33 6.85e-10 P wave terminal force; LUSC trans rs28735056 1.000 rs28865701 chr18:77620911 A/G cg03973167 chr4:185394988 IRF2 0.44 6.17 0.32 1.96e-9 Schizophrenia; LUSC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg11812906 chr14:75593930 NEK9 -0.67 -10.97 -0.51 4.01e-24 Height; LUSC cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg13319975 chr6:146136371 FBXO30 0.5 7.44 0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg03161606 chr19:29218774 NA 0.57 6.89 0.35 2.76e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs2786098 0.656 rs10922256 chr1:197545307 C/T cg16005942 chr6:160526640 IGF2R 0.51 6.05 0.31 3.93e-9 Asthma; LUSC cis rs11098499 0.754 rs714899 chr4:120243035 G/A cg24375607 chr4:120327624 NA 0.76 12.15 0.55 2.15e-28 Corneal astigmatism; LUSC cis rs208520 0.526 rs9294682 chr6:66795159 G/A cg07460842 chr6:66804631 NA -1.26 -27.65 -0.83 2.31e-88 Exhaled nitric oxide output; LUSC cis rs12369635 0.929 rs3851667 chr12:129550552 G/T cg01909103 chr12:129572610 TMEM132D 0.63 6.4 0.33 5.31e-10 Schizophrenia (inflammation and infection response interaction); LUSC cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg00071950 chr4:10020882 SLC2A9 0.67 11.22 0.52 5.24e-25 Bone mineral density; LUSC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg26597838 chr10:835615 NA -0.69 -10.87 -0.51 9.11e-24 Eosinophil percentage of granulocytes; LUSC cis rs9911578 0.835 rs9889419 chr17:56473259 C/T cg05425664 chr17:57184151 TRIM37 -0.53 -8.35 -0.42 1.9e-15 Intelligence (multi-trait analysis); LUSC trans rs6502050 0.765 rs55905076 chr17:80105441 G/A cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.17e-10 Life satisfaction; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg14004847 chr7:1930337 MAD1L1 -0.58 -9.04 -0.44 1.34e-17 Bipolar disorder and schizophrenia; LUSC cis rs865483 0.860 rs860468 chr17:35793286 G/C cg06716730 chr17:35851459 DUSP14 0.27 5.92 0.31 7.89e-9 Monocyte count; LUSC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.11 -0.36 6.95e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2348418 0.864 rs2137071 chr12:28716730 T/C cg13890972 chr12:28721907 NA -0.33 -5.75 -0.3 2.06e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg17376030 chr22:41985996 PMM1 0.51 6.03 0.31 4.44e-9 Vitiligo; LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.36 -0.37 1.45e-12 Height; LUSC cis rs738321 0.725 rs9622738 chr22:38542346 G/A cg25457927 chr22:38595422 NA -0.42 -8.1 -0.41 1.01e-14 Breast cancer; LUSC trans rs7819412 0.668 rs4841507 chr8:11046394 C/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.3 -0.37 2.11e-12 Triglycerides; LUSC cis rs9296092 0.538 rs9461882 chr6:33520221 A/C cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.77e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg26314531 chr2:26401878 FAM59B -0.67 -9.09 -0.45 8.85e-18 Gut microbiome composition (summer); LUSC cis rs2239547 0.603 rs4687698 chr3:53097108 C/T cg11645453 chr3:52864694 ITIH4 0.47 10.77 0.51 2.03e-23 Schizophrenia; LUSC cis rs7582180 0.629 rs2309798 chr2:100956949 G/A cg12002119 chr2:101014098 CHST10 0.35 5.74 0.3 2.07e-8 Intelligence (multi-trait analysis); LUSC cis rs7769051 0.522 rs73550455 chr6:133096633 A/G cg07930552 chr6:133119739 C6orf192 0.83 7.74 0.39 1.16e-13 Type 2 diabetes nephropathy; LUSC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg18252515 chr7:66147081 NA -0.4 -5.75 -0.3 2e-8 Aortic root size; LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg16405210 chr4:1374714 KIAA1530 0.69 10.74 0.51 2.57e-23 Obesity-related traits; LUSC cis rs9527 0.615 rs7073295 chr10:104672233 A/G cg08330031 chr10:104623503 C10orf32 0.32 5.69 0.3 2.76e-8 Arsenic metabolism; LUSC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.68 0.63 5.52e-38 Menopause (age at onset); LUSC cis rs4631830 0.863 rs2926494 chr10:51517356 T/C cg16070123 chr10:51489643 NA -0.51 -7.91 -0.4 3.78e-14 Prostate-specific antigen levels; LUSC cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.84 -0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.23 0.56 1.14e-28 Prudent dietary pattern; LUSC cis rs9650657 0.769 rs2116093 chr8:10613299 C/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.09 -0.32 3.17e-9 Neuroticism; LUSC cis rs6599077 0.616 rs9883358 chr3:40175631 A/G cg13683864 chr3:40499215 RPL14 -0.54 -6.78 -0.35 5.54e-11 Sleep-related phenotypes; LUSC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg13390004 chr1:15929781 NA 0.42 7.0 0.36 1.43e-11 Systolic blood pressure; LUSC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.2 -0.32 1.68e-9 Menopause (age at onset); LUSC cis rs10733682 0.659 rs13292976 chr9:129467340 C/T cg00232160 chr9:129468157 NA 0.43 8.09 0.4 1.13e-14 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg24788636 chr1:40562667 PPT1 0.33 6.26 0.32 1.16e-9 Tuberculosis; LUSC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg13939156 chr17:80058883 NA -0.33 -6.39 -0.33 5.53e-10 Life satisfaction; LUSC trans rs208520 0.661 rs7747492 chr6:66857788 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.68 -0.67 7.09e-46 Exhaled nitric oxide output; LUSC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.37 0.33 6.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg02951883 chr7:2050386 MAD1L1 -0.58 -10.52 -0.5 1.54e-22 Bipolar disorder and schizophrenia; LUSC cis rs67072384 0.818 rs1872127 chr11:72465085 G/A cg04827223 chr11:72435913 ARAP1 -0.73 -6.35 -0.33 7.13e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.62e-9 Aortic root size; LUSC cis rs2073300 0.609 rs1936011 chr20:23341912 G/C cg09953122 chr20:23471693 CST8 -0.67 -5.72 -0.3 2.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs72634258 0.796 rs10746475 chr1:8168261 T/A cg00042356 chr1:8021962 PARK7 -0.54 -6.65 -0.34 1.19e-10 Inflammatory bowel disease; LUSC cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.31e-41 Bladder cancer; LUSC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs4253772 0.530 rs11090875 chr22:46785301 C/T cg24881330 chr22:46731750 TRMU 0.84 6.38 0.33 5.92e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg12463550 chr7:65579703 CRCP -0.43 -6.36 -0.33 6.61e-10 Aortic root size; LUSC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg02487422 chr3:49467188 NICN1 0.43 6.82 0.35 4.23e-11 Resting heart rate; LUSC trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg03929089 chr4:120376271 NA 0.82 11.67 0.54 1.27e-26 Coronary artery disease; LUSC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg13298116 chr11:62369859 EML3;MTA2 0.58 9.54 0.46 3.02e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.17 -0.32 1.95e-9 Electroencephalogram traits; LUSC trans rs11039798 1.000 rs11039798 chr11:48540223 G/A cg15704280 chr7:45808275 SEPT13 0.75 6.44 0.33 4.2e-10 Axial length; LUSC cis rs9611519 0.964 rs5995992 chr22:41487218 T/C cg13813247 chr22:41461852 NA -0.37 -6.56 -0.34 2.04e-10 Neuroticism; LUSC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg18240062 chr17:79603768 NPLOC4 0.58 10.19 0.49 2.01e-21 Eye color traits; LUSC cis rs7589342 0.839 rs1465641 chr2:106438936 C/T cg14210321 chr2:106509881 NCK2 -0.53 -7.98 -0.4 2.44e-14 Addiction; LUSC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.73 -12.49 -0.56 1.23e-29 Total body bone mineral density; LUSC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg06481639 chr22:41940642 POLR3H -0.47 -5.78 -0.3 1.71e-8 Vitiligo; LUSC cis rs62400317 0.826 rs12205642 chr6:45331765 T/C cg18551225 chr6:44695536 NA -0.44 -7.32 -0.37 1.92e-12 Total body bone mineral density; LUSC cis rs992157 1.000 rs4791 chr2:219138940 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.55 8.28 0.41 2.98e-15 Colorectal cancer; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.43 0.53 9.29e-26 Prudent dietary pattern; LUSC cis rs6582630 0.584 rs12832156 chr12:38419435 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.55 -0.34 2.12e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7903847 0.656 rs61861861 chr10:99143619 C/T cg20016023 chr10:99160130 RRP12 -0.28 -6.15 -0.32 2.17e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6723226 0.572 rs176404 chr2:32638846 T/C cg02381751 chr2:32503542 YIPF4 -0.51 -7.95 -0.4 2.95e-14 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs8072100 1.000 rs3809868 chr17:45750596 G/A cg08085267 chr17:45401833 C17orf57 0.6 10.0 0.48 9.4e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs295140 0.546 rs295134 chr2:201110223 A/G cg23649088 chr2:200775458 C2orf69 -0.43 -6.42 -0.33 4.55e-10 QT interval; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg16393715 chr7:1948819 MAD1L1 0.39 6.72 0.34 8.09e-11 Bipolar disorder and schizophrenia; LUSC cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.53 0.34 2.52e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9473147 0.543 rs9296558 chr6:47451883 C/T cg02130027 chr6:47444894 CD2AP 0.36 5.85 0.3 1.2e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs3820928 0.874 rs4234064 chr2:227857497 G/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.63 -0.39 2.47e-13 Pulmonary function; LUSC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg17724175 chr1:150552817 MCL1 0.36 6.61 0.34 1.56e-10 Tonsillectomy; LUSC trans rs6502050 0.835 rs7221451 chr17:80089785 A/G cg07393940 chr7:158741817 NA 0.38 6.91 0.35 2.53e-11 Life satisfaction; LUSC cis rs897984 0.644 rs73524556 chr16:30823162 G/A cg02466173 chr16:30829666 NA -0.68 -16.48 -0.67 4.71e-45 Dementia with Lewy bodies; LUSC cis rs8017423 0.740 rs7152196 chr14:90703900 G/T cg14092571 chr14:90743983 NA -0.35 -5.74 -0.3 2.1e-8 Mortality in heart failure; LUSC cis rs7180079 1.000 rs8032196 chr15:64515822 A/C cg08069370 chr15:64387884 SNX1 -0.54 -5.79 -0.3 1.63e-8 Monocyte count; LUSC cis rs68170813 0.652 rs17482543 chr7:107169174 C/G cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs7927771 0.524 rs12286721 chr11:47701528 G/T cg20307385 chr11:47447363 PSMC3 -0.43 -6.3 -0.33 9.64e-10 Subjective well-being; LUSC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.7 -0.34 8.72e-11 Tonsillectomy; LUSC cis rs1639906 1.000 rs1639906 chr7:2219966 T/C cg18044113 chr7:2236405 MAD1L1 -0.33 -6.2 -0.32 1.66e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg13010344 chr12:123464640 ARL6IP4 0.45 6.76 0.35 6.04e-11 Neutrophil percentage of white cells; LUSC cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg11189052 chr15:85197271 WDR73 0.53 5.98 0.31 5.81e-9 Schizophrenia; LUSC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg18758796 chr5:131593413 PDLIM4 0.43 7.28 0.37 2.4e-12 Breast cancer; LUSC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg05623727 chr3:50126028 RBM5 0.34 6.39 0.33 5.71e-10 Intelligence (multi-trait analysis); LUSC cis rs6964587 0.967 rs55801687 chr7:91762629 C/A cg01689657 chr7:91764605 CYP51A1 0.34 6.12 0.32 2.69e-9 Breast cancer; LUSC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg03676636 chr4:99064102 C4orf37 0.34 7.42 0.38 9.87e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7923609 0.967 rs10761766 chr10:65190327 G/A cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.9 -0.31 8.73e-9 Platelet count; LUSC cis rs6066835 1.000 rs56343427 chr20:47355273 C/T cg18078177 chr20:47281410 PREX1 0.72 6.23 0.32 1.42e-9 Multiple myeloma; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg14948946 chr7:45151503 TBRG4 0.39 6.01 0.31 4.92e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs7106204 0.514 rs12293105 chr11:24256048 T/C ch.11.24196551F chr11:24239977 NA 0.94 10.41 0.49 3.63e-22 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg08677398 chr8:58056175 NA 0.49 6.14 0.32 2.38e-9 Developmental language disorder (linguistic errors); LUSC cis rs6684514 0.542 rs11264472 chr1:156292366 A/G cg20302342 chr1:156215951 PAQR6 0.33 6.29 0.33 9.91e-10 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs950169 0.649 rs12911612 chr15:84691014 T/C cg17173187 chr15:85201210 NMB 0.4 6.53 0.34 2.43e-10 Schizophrenia; LUSC cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg07606381 chr6:8435919 SLC35B3 0.72 12.13 0.55 2.61e-28 Motion sickness; LUSC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg16545954 chr1:2118288 C1orf86 0.32 6.22 0.32 1.45e-9 Height; LUSC trans rs9951602 0.512 rs8089108 chr18:76651361 C/T cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC cis rs9303401 0.659 rs62083368 chr17:56878062 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.71 0.6 3.09e-34 Cognitive test performance; LUSC cis rs3916 0.641 rs7964786 chr12:121132100 C/T cg27246729 chr12:121163418 ACADS 0.4 6.2 0.32 1.7e-9 Urinary metabolites (H-NMR features); LUSC cis rs7917772 0.582 rs10786689 chr10:104356359 T/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.26e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11645898 0.688 rs398580 chr16:72095453 A/G cg14768367 chr16:72042858 DHODH -0.73 -7.93 -0.4 3.22e-14 Blood protein levels; LUSC cis rs7937682 1.000 rs10789843 chr11:111576158 C/T cg19812747 chr11:111475976 SIK2 0.49 6.76 0.35 6.2e-11 Primary sclerosing cholangitis; LUSC cis rs1670533 0.872 rs935969 chr4:1062588 A/G cg27284194 chr4:1044797 NA 0.61 8.78 0.43 8.66e-17 Recombination rate (females); LUSC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2227930 0.506 rs9814159 chr3:142125922 C/G cg16271453 chr3:142027066 XRN1 -0.55 -9.76 -0.47 5.83e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg26647111 chr11:31128758 NA -0.41 -5.98 -0.31 5.7e-9 Red blood cell count; LUSC trans rs61931739 0.500 rs11053198 chr12:34444013 G/C cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.51e-34 Morning vs. evening chronotype; LUSC cis rs860295 0.756 rs7546258 chr1:155698645 T/A cg08949192 chr1:155289623 RUSC1;FDPS -0.35 -5.78 -0.3 1.68e-8 Body mass index; LUSC cis rs7216064 1.000 rs7210027 chr17:65977053 C/T cg12091567 chr17:66097778 LOC651250 0.69 9.34 0.46 1.42e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs17029056 0.527 rs17029053 chr2:42158297 C/G cg25815440 chr2:42134162 NA 0.34 6.85 0.35 3.61e-11 Breast cancer; LUSC cis rs7773004 1.000 rs1155207 chr6:26328365 A/G cg00631329 chr6:26305371 NA -0.32 -5.73 -0.3 2.25e-8 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9309473 0.950 rs6546853 chr2:73833739 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.63 -0.34 1.37e-10 Metabolite levels; LUSC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg03806693 chr22:41940476 POLR3H -1.02 -13.77 -0.6 1.74e-34 Vitiligo; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg12229632 chr17:2607906 KIAA0664 -0.38 -6.01 -0.31 4.95e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7020830 0.931 rs7851239 chr9:37138672 A/G cg14294708 chr9:37120828 ZCCHC7 -0.97 -18.7 -0.72 6.85e-54 Schizophrenia; LUSC cis rs7592578 0.679 rs62181018 chr2:191323295 C/T cg10560079 chr2:191398806 TMEM194B -0.66 -8.29 -0.41 2.85e-15 Diastolic blood pressure; LUSC cis rs6060960 0.502 rs6089110 chr20:30486907 A/T cg13852791 chr20:30311386 BCL2L1 0.64 6.79 0.35 5.17e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg18876405 chr7:65276391 NA 0.65 11.6 0.54 2.18e-26 Aortic root size; LUSC cis rs7215564 0.730 rs7212125 chr17:78628863 C/T cg23238734 chr17:78661607 RPTOR -0.44 -5.94 -0.31 7.15e-9 Myopia (pathological); LUSC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg22437258 chr11:111473054 SIK2 0.49 6.67 0.34 1.06e-10 Primary sclerosing cholangitis; LUSC cis rs11650494 0.908 rs73324323 chr17:47420054 G/T cg08112188 chr17:47440006 ZNF652 1.19 9.8 0.47 4.43e-20 Prostate cancer; LUSC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg24675056 chr1:15929824 NA 0.49 8.47 0.42 7.99e-16 Systolic blood pressure; LUSC cis rs1595825 0.891 rs77032596 chr2:198603185 T/G cg00982548 chr2:198649783 BOLL -0.56 -6.94 -0.35 2.06e-11 Ulcerative colitis; LUSC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg12463550 chr7:65579703 CRCP 0.42 6.04 0.31 4.13e-9 Aortic root size; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -8.94 -0.44 2.64e-17 Bipolar disorder and schizophrenia; LUSC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -7.9 -0.4 4.1e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg05347473 chr6:146136440 FBXO30 0.51 8.76 0.43 9.89e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs208520 0.690 rs207081 chr6:66773742 A/G cg07460842 chr6:66804631 NA -1.11 -17.3 -0.69 2.55e-48 Exhaled nitric oxide output; LUSC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs17401966 1.000 rs12734551 chr1:10391536 A/C cg19773385 chr1:10388646 KIF1B -0.56 -8.75 -0.43 1.07e-16 Hepatocellular carcinoma; LUSC cis rs1728785 0.786 rs1728770 chr16:68564124 G/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.75 -0.3 2e-8 Ulcerative colitis; LUSC cis rs2235642 0.592 rs743963 chr16:1657350 A/T cg09025071 chr16:1593152 IFT140;TMEM204 0.28 6.2 0.32 1.69e-9 Coronary artery disease; LUSC cis rs897984 0.721 rs4889525 chr16:30989858 T/C cg02466173 chr16:30829666 NA 0.55 11.21 0.52 5.56e-25 Dementia with Lewy bodies; LUSC cis rs6967385 0.560 rs4301352 chr7:12356481 T/G cg06484146 chr7:12443880 VWDE 0.51 7.65 0.39 2.21e-13 Response to taxane treatment (placlitaxel); LUSC cis rs4466137 0.553 rs16898 chr5:82986149 T/C cg15083037 chr5:83017644 HAPLN1 -0.48 -7.0 -0.36 1.45e-11 Prostate cancer; LUSC trans rs61931739 0.534 rs6488189 chr12:33995865 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.37 0.53 1.55e-25 Morning vs. evening chronotype; LUSC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs4730250 0.707 rs78472146 chr7:106967491 C/A cg02696742 chr7:106810147 HBP1 -0.65 -9.76 -0.47 5.95e-20 Osteoarthritis; LUSC cis rs1371867 0.846 rs1660323 chr8:101278724 T/A cg06002616 chr8:101225028 SPAG1 -0.44 -7.3 -0.37 2.18e-12 Atrioventricular conduction; LUSC cis rs1335645 0.570 rs10494127 chr1:111671783 A/C cg00321911 chr1:111669324 DRAM2 -0.61 -6.43 -0.33 4.29e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg01097406 chr16:89675127 NA -0.34 -6.79 -0.35 5.06e-11 Vitiligo; LUSC cis rs6489882 0.902 rs7966314 chr12:113372539 C/T cg20102336 chr12:113376681 OAS3 0.41 6.03 0.31 4.29e-9 Chronic lymphocytic leukemia; LUSC cis rs62103177 0.608 rs59300126 chr18:77694439 C/A cg20368463 chr18:77673604 PQLC1 0.7 6.96 0.36 1.83e-11 Opioid sensitivity; LUSC cis rs1670533 1.000 rs10026482 chr4:1051128 C/G cg02018176 chr4:1364513 KIAA1530 0.46 6.44 0.33 4.26e-10 Recombination rate (females); LUSC cis rs9300255 0.602 rs4372492 chr12:123697357 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs9549367 0.756 rs3861723 chr13:113910926 A/G cg00898013 chr13:113819073 PROZ -0.48 -7.19 -0.37 4.38e-12 Platelet distribution width; LUSC cis rs2742417 1.000 rs2742390 chr3:45756722 A/G cg04837898 chr3:45731254 SACM1L 0.35 5.88 0.31 9.89e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg21211367 chr2:162094118 NA 0.44 7.13 0.36 6.38e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs709400 0.894 rs61996721 chr14:104061352 G/A cg24130564 chr14:104152367 KLC1 -0.5 -7.18 -0.37 4.57e-12 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22619719 chr1:1891578 KIAA1751 0.41 6.23 0.32 1.41e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.15e-9 Mean platelet volume; LUSC cis rs11758351 1.000 rs111596617 chr6:26191678 A/T cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC cis rs9300255 0.620 rs1716173 chr12:123660721 A/T cg05973401 chr12:123451056 ABCB9 0.52 6.45 0.33 3.85e-10 Neutrophil percentage of white cells; LUSC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg06634786 chr22:41940651 POLR3H -0.55 -6.41 -0.33 5.05e-10 Vitiligo; LUSC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); LUSC cis rs546131 0.928 rs552627 chr11:34826680 G/A cg11058730 chr11:34937778 PDHX;APIP 0.43 5.84 0.3 1.23e-8 Lung disease severity in cystic fibrosis; LUSC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg03289416 chr15:75166202 SCAMP2 0.4 6.08 0.32 3.2e-9 Breast cancer; LUSC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.78 11.51 0.53 4.68e-26 Cognitive test performance; LUSC cis rs6496667 0.532 rs2601207 chr15:90963542 C/G cg22089800 chr15:90895588 ZNF774 -0.51 -7.49 -0.38 6.16e-13 Rheumatoid arthritis; LUSC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg23205692 chr1:25664452 TMEM50A -0.4 -5.98 -0.31 5.7e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs79387448 0.592 rs6728945 chr2:102986471 T/C cg09003973 chr2:102972529 NA 1.22 12.92 0.58 3e-31 Gut microbiota (bacterial taxa); LUSC cis rs3806843 0.966 rs1030166 chr5:140185473 G/A cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg19774624 chr17:42201019 HDAC5 0.8 12.82 0.57 7.44e-31 Total body bone mineral density; LUSC cis rs11190604 1.000 rs2273694 chr10:102256496 G/T cg16342193 chr10:102329863 NA -0.33 -6.1 -0.32 2.97e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg17173187 chr15:85201210 NMB -0.28 -5.65 -0.3 3.53e-8 P wave terminal force; LUSC cis rs1448094 0.967 rs10863115 chr12:86332586 T/C cg00310523 chr12:86230176 RASSF9 0.39 7.06 0.36 9.83e-12 Major depressive disorder; LUSC cis rs708547 0.647 rs1718830 chr4:57888510 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.64 0.39 2.25e-13 Response to bleomycin (chromatid breaks); LUSC cis rs3772130 0.961 rs11716984 chr3:121362407 A/T cg01951420 chr3:121553821 IQCB1;EAF2 0.66 9.67 0.47 1.13e-19 Cognitive performance; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00797030 chr17:8151304 PFAS;C17orf68 0.75 6.02 0.31 4.47e-9 Cognitive performance; LUSC cis rs2481665 0.772 rs6668421 chr1:62536619 C/G cg18591186 chr1:62594603 INADL -0.48 -7.5 -0.38 5.68e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs612683 0.536 rs1335753 chr1:101027157 G/T cg09408571 chr1:101003634 GPR88 0.32 6.07 0.32 3.52e-9 Breast cancer; LUSC cis rs1113500 0.933 rs61797345 chr1:108623728 G/A cg11967332 chr1:108735228 SLC25A24 0.38 5.78 0.3 1.74e-8 Growth-regulated protein alpha levels; LUSC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg06108461 chr20:60628389 TAF4 -0.98 -16.38 -0.67 1.11e-44 Body mass index; LUSC cis rs4808199 0.847 rs34647936 chr19:19548239 T/G cg03709012 chr19:19516395 GATAD2A 1.12 15.24 0.64 3.58e-40 Nonalcoholic fatty liver disease; LUSC cis rs17255340 0.520 rs1145911 chr6:84002954 T/C cg08257003 chr6:84140564 ME1 0.31 7.62 0.38 2.6e-13 Platelet-derived growth factor BB levels; LUSC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg12560992 chr17:57184187 TRIM37 0.64 10.99 0.52 3.38e-24 Intelligence (multi-trait analysis); LUSC cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg21609526 chr1:3105151 PRDM16 -0.31 -6.17 -0.32 1.93e-9 Migraine; LUSC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg22800045 chr5:56110881 MAP3K1 0.76 9.84 0.47 3.24e-20 Initial pursuit acceleration; LUSC cis rs7843479 0.965 rs11135742 chr8:21802910 A/T cg17168535 chr8:21777572 XPO7 0.68 10.65 0.5 5.19e-23 Mean corpuscular volume; LUSC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg15921436 chr17:44337874 NA 0.72 10.99 0.52 3.35e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg18876405 chr7:65276391 NA 0.58 9.51 0.46 3.99e-19 Aortic root size; LUSC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg26335602 chr6:28129616 ZNF389 0.44 5.97 0.31 6.22e-9 Depression; LUSC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg03161606 chr19:29218774 NA 0.56 6.85 0.35 3.64e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs3020736 0.500 rs764481 chr22:42518426 G/A cg15557168 chr22:42548783 NA 0.47 7.16 0.36 5.26e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs4478858 0.775 rs6685868 chr1:31706956 C/T cg00250761 chr1:31883323 NA -0.36 -9.32 -0.45 1.59e-18 Alcohol dependence; LUSC cis rs9472414 0.680 rs9463020 chr6:44713432 G/A cg20913747 chr6:44695427 NA 0.39 5.67 0.3 3.16e-8 Height; LUSC cis rs1994135 0.630 rs11052757 chr12:33719879 A/G cg06521331 chr12:34319734 NA -0.4 -5.69 -0.3 2.76e-8 Resting heart rate; LUSC cis rs1372520 0.935 rs1442152 chr4:90775649 C/A cg01966878 chr4:90757139 SNCA -0.4 -5.72 -0.3 2.38e-8 Neuroticism; LUSC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs56399783 0.901 rs11764225 chr7:2775607 G/A cg19731401 chr7:2775893 GNA12 0.74 9.17 0.45 4.93e-18 Childhood ear infection; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg09436375 chr6:42928200 GNMT -0.29 -6.85 -0.35 3.63e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg09184832 chr6:79620586 NA -0.44 -7.01 -0.36 1.34e-11 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.96e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7193541 0.859 rs12598791 chr16:74500745 A/C cg01733217 chr16:74700730 RFWD3 0.78 13.67 0.6 4.2e-34 Multiple myeloma; LUSC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg08219700 chr8:58056026 NA 0.57 6.81 0.35 4.53e-11 Developmental language disorder (linguistic errors); LUSC cis rs12530845 1.000 rs4291212 chr7:135335465 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs9287719 0.935 rs6751075 chr2:10723546 C/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.96e-9 Prostate cancer; LUSC cis rs2839186 0.869 rs17176513 chr21:47682428 A/G cg12016809 chr21:47604291 C21orf56 0.38 5.66 0.3 3.25e-8 Testicular germ cell tumor; LUSC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg00933542 chr6:150070202 PCMT1 0.33 6.82 0.35 4.38e-11 Lung cancer; LUSC cis rs7189233 0.955 rs60420081 chr16:53520804 A/G cg09728985 chr16:53543985 NA -0.33 -6.02 -0.31 4.58e-9 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg25767906 chr1:53392781 SCP2 0.48 8.47 0.42 8.04e-16 Monocyte count; LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg14004847 chr7:1930337 MAD1L1 -0.5 -7.65 -0.39 2.1e-13 Bipolar disorder and schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18794664 chr1:42922694 ZMYND12;PPCS -0.45 -6.07 -0.32 3.48e-9 Hepatitis; LUSC cis rs909341 0.818 rs6122154 chr20:62359345 C/T cg09650180 chr20:62225654 GMEB2 -0.45 -5.81 -0.3 1.48e-8 Atopic dermatitis; LUSC cis rs2398893 1.000 rs1411861 chr9:96763614 A/G cg14459158 chr9:96720562 NA 0.33 6.27 0.32 1.11e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.87 -0.31 1.04e-8 Lung cancer; LUSC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg00339695 chr16:24857497 SLC5A11 -0.5 -8.24 -0.41 3.91e-15 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.666 rs10179910 chr2:99658503 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.47 -0.56 1.48e-29 Chronic sinus infection; LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg12564285 chr5:131593104 PDLIM4 0.46 8.12 0.41 9.17e-15 Breast cancer; LUSC cis rs131777 0.708 rs131749 chr22:51024624 C/T cg25575065 chr22:51066394 ARSA 0.42 5.89 0.31 9.53e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1371867 0.846 rs1788189 chr8:101249762 G/T cg06002616 chr8:101225028 SPAG1 0.42 7.11 0.36 6.91e-12 Atrioventricular conduction; LUSC cis rs7769051 1.000 rs6934161 chr6:133124077 C/T cg22852734 chr6:133119734 C6orf192 -1.17 -14.37 -0.62 8.34e-37 Type 2 diabetes nephropathy; LUSC cis rs7588746 0.621 rs11691757 chr2:201148951 C/T cg23649088 chr2:200775458 C2orf69 -0.42 -5.91 -0.31 8.36e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg07092213 chr7:1199455 ZFAND2A -0.43 -6.68 -0.34 9.79e-11 Longevity;Endometriosis; LUSC cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg09184832 chr6:79620586 NA -0.43 -6.94 -0.36 1.99e-11 Intelligence (multi-trait analysis); LUSC cis rs4891159 0.513 rs2554831 chr18:74113513 C/G cg24786174 chr18:74118243 ZNF516 0.92 19.57 0.73 2.3e-57 Longevity; LUSC cis rs3784262 0.528 rs11071364 chr15:58334113 C/G cg12031962 chr15:58353849 ALDH1A2 -0.3 -5.64 -0.3 3.57e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7927771 0.524 rs10838760 chr11:47786414 A/G cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs7215564 0.908 rs4243240 chr17:78660342 T/C cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.71 -0.6 3.02e-34 Intelligence (multi-trait analysis); LUSC trans rs12885454 1.000 rs35625199 chr14:29740239 A/C cg13430755 chr9:110310795 NA -0.31 -5.96 -0.31 6.42e-9 Body mass index (joint analysis main effects and smoking interaction);Waist circumference;Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index; LUSC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg10556349 chr10:835070 NA 0.57 6.44 0.33 4.19e-10 Eosinophil percentage of granulocytes; LUSC cis rs1160297 0.609 rs1597653 chr2:53100420 A/G cg07782112 chr2:53107842 NA -0.42 -6.92 -0.35 2.31e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs3806843 0.933 rs2240696 chr5:140168070 A/G cg26395211 chr5:140044315 WDR55 -0.37 -5.77 -0.3 1.78e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.81 -0.35 4.49e-11 Menopause (age at onset); LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs7927592 0.956 rs7102273 chr11:68385579 T/C cg16797656 chr11:68205561 LRP5 0.35 5.94 0.31 7.22e-9 Total body bone mineral density; LUSC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg21963583 chr11:68658836 MRPL21 0.56 8.42 0.42 1.15e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs765787 0.530 rs4775819 chr15:45525966 C/T cg25801113 chr15:45476975 SHF 0.33 6.87 0.35 3.14e-11 Uric acid levels; LUSC cis rs597539 0.521 rs2060982 chr11:68612927 A/G cg21963583 chr11:68658836 MRPL21 0.41 6.86 0.35 3.33e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg22532475 chr10:104410764 TRIM8 0.32 6.41 0.33 4.88e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg17178900 chr1:205818956 PM20D1 0.67 10.61 0.5 7.38e-23 Menarche (age at onset); LUSC cis rs72634258 0.945 rs225120 chr1:8046378 C/T cg00042356 chr1:8021962 PARK7 0.64 8.37 0.42 1.55e-15 Inflammatory bowel disease; LUSC cis rs1018836 0.608 rs6998106 chr8:91479755 G/T cg16814680 chr8:91681699 NA -0.56 -8.24 -0.41 4.06e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.78 0.43 8.9e-17 Menopause (age at onset); LUSC cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.89 -11.73 -0.54 7.89e-27 Chronic sinus infection; LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg11494091 chr17:61959527 GH2 0.64 13.57 0.6 1e-33 Prudent dietary pattern; LUSC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg21918786 chr6:109611834 NA 0.41 6.97 0.36 1.71e-11 Reticulocyte fraction of red cells; LUSC cis rs3806843 0.735 rs2563306 chr5:140070017 C/T cg26395211 chr5:140044315 WDR55 0.45 6.99 0.36 1.5e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs951366 0.576 rs12046305 chr1:205714478 G/A cg24503407 chr1:205819492 PM20D1 -0.48 -6.38 -0.33 6.01e-10 Menarche (age at onset); LUSC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg23711669 chr6:146136114 FBXO30 0.88 16.26 0.66 3.33e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs1775715 0.707 rs1541261 chr10:32179523 G/A cg18675610 chr10:32216311 ARHGAP12 0.31 6.67 0.34 1.07e-10 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs3808502 0.549 rs1382563 chr8:11426790 C/G cg11608241 chr8:8085544 FLJ10661 0.44 6.51 0.34 2.82e-10 Neuroticism; LUSC cis rs2637266 0.783 rs2395436 chr10:78488513 G/T cg18941641 chr10:78392320 NA 0.38 6.9 0.35 2.59e-11 Pulmonary function; LUSC cis rs68170813 0.559 rs3801958 chr7:106961139 C/T cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.65 -0.3 3.48e-8 Coronary artery disease; LUSC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg25019033 chr10:957182 NA -0.51 -6.49 -0.33 3.03e-10 Eosinophil percentage of granulocytes; LUSC trans rs2832191 0.679 rs2705659 chr21:30363908 G/C cg14791747 chr16:20752902 THUMPD1 -0.41 -6.41 -0.33 4.94e-10 Dental caries; LUSC cis rs11971779 0.680 rs10085902 chr7:139109105 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs11252926 0.563 rs10904173 chr10:462885 G/A cg16346588 chr10:242978 ZMYND11 -0.41 -5.67 -0.3 3.12e-8 Psychosis in Alzheimer's disease; LUSC cis rs8141529 0.644 rs5752795 chr22:29178820 T/C cg15103426 chr22:29168792 CCDC117 0.6 8.35 0.42 1.87e-15 Lymphocyte counts; LUSC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg14583973 chr4:3374767 RGS12 0.37 7.82 0.39 6.99e-14 Serum sulfate level; LUSC cis rs34779708 0.966 rs12769484 chr10:35465746 G/A cg04310649 chr10:35416472 CREM -0.42 -6.46 -0.33 3.63e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9447004 0.584 rs56093139 chr6:74432923 C/T cg03006477 chr6:74432658 CD109 0.28 5.84 0.3 1.27e-8 Blood protein levels;Calcium levels; LUSC cis rs12464559 0.522 rs10200512 chr2:152626147 T/C cg01189475 chr2:152685088 ARL5A 0.63 6.94 0.35 2.08e-11 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg00431813 chr7:1051703 C7orf50 -0.44 -7.11 -0.36 7.04e-12 Longevity;Endometriosis; LUSC cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg25817165 chr18:72167213 CNDP2 -0.75 -9.1 -0.45 8.37e-18 Refractive error; LUSC cis rs754466 0.606 rs11002310 chr10:79596030 A/C cg17075019 chr10:79541650 NA -0.77 -12.62 -0.57 4.01e-30 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs500891 0.553 rs2095447 chr6:84112756 C/G cg08257003 chr6:84140564 ME1 -0.37 -8.79 -0.43 8.04e-17 Platelet-derived growth factor BB levels; LUSC cis rs713477 1.000 rs8010013 chr14:55884828 A/C cg13175173 chr14:55914753 NA -0.29 -6.06 -0.31 3.63e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs10191773 0.589 rs72831639 chr2:112949291 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.61 -6.29 -0.33 1.02e-9 Yeast infection; LUSC cis rs72802342 0.541 rs185052 chr16:75467063 C/T cg04384234 chr16:75411784 CFDP1 0.7 9.66 0.47 1.23e-19 Advanced age-related macular degeneration; LUSC trans rs11098499 0.754 rs12507565 chr4:120251121 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs2479724 0.935 rs2254936 chr6:41846569 A/G cg17623882 chr6:41773611 USP49 -0.65 -11.06 -0.52 1.94e-24 Menarche (age at onset); LUSC trans rs60843830 1.000 rs62114501 chr2:231741 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.42 0.5 3.29e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6754311 0.593 rs4954280 chr2:136420690 C/T cg07169764 chr2:136633963 MCM6 -0.54 -7.13 -0.36 6.1e-12 Mosquito bite size; LUSC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.87 -0.44 4.51e-17 Neuroticism; LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg18402987 chr7:1209562 NA 0.73 7.85 0.39 5.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg02018176 chr4:1364513 KIAA1530 0.48 8.4 0.42 1.26e-15 Obesity-related traits; LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2667011 0.512 rs61094689 chr2:160797597 A/C cg06573604 chr2:160760825 LY75 0.43 6.15 0.32 2.22e-9 Bilirubin levels; LUSC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg15921436 chr17:44337874 NA -0.71 -10.86 -0.51 9.89e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg15445000 chr17:37608096 MED1 0.38 6.5 0.34 2.95e-10 Glomerular filtration rate (creatinine); LUSC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.64 6.24 0.32 1.34e-9 Cerebrospinal P-tau181p levels; LUSC cis rs57466243 1 rs57466243 chr17:27059666 T/A cg21795637 chr17:26881880 PIGS 0.35 5.68 0.3 2.87e-8 Reticulocyte count; LUSC cis rs16976116 0.851 rs28699327 chr15:55500335 A/G cg11288833 chr15:55489084 RSL24D1 0.49 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9486715 0.867 rs9384585 chr6:96875664 C/T cg06623918 chr6:96969491 KIAA0776 0.93 17.58 0.69 1.94e-49 Headache; LUSC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg12257692 chr3:49977190 RBM6 0.21 5.8 0.3 1.54e-8 Intelligence (multi-trait analysis); LUSC cis rs941408 0.890 rs1640269 chr19:2793194 A/C cg06609049 chr19:2785107 THOP1 0.74 11.5 0.53 5.24e-26 Total cholesterol levels; LUSC cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.41 6.6 0.34 1.64e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs709400 0.628 rs2273700 chr14:103923414 A/G cg10523860 chr14:103875565 MARK3 -0.36 -5.66 -0.3 3.26e-8 Body mass index; LUSC cis rs1178968 1.000 rs4273741 chr7:72773966 C/A cg25889504 chr7:72793014 NA 0.6 7.8 0.39 7.86e-14 Triglyceride levels; LUSC cis rs68170813 0.559 rs7779062 chr7:106880195 T/A cg02696742 chr7:106810147 HBP1 -0.63 -9.66 -0.47 1.24e-19 Coronary artery disease; LUSC cis rs10751667 1.000 rs7395691 chr11:985006 T/C cg06064525 chr11:970664 AP2A2 -0.34 -6.72 -0.35 7.69e-11 Alzheimer's disease (late onset); LUSC cis rs7208859 0.623 rs7223209 chr17:29107220 C/A cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg22782873 chr19:19639568 YJEFN3 -0.49 -6.15 -0.32 2.23e-9 Bipolar disorder; LUSC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg16414030 chr3:133502952 NA -0.5 -7.93 -0.4 3.32e-14 Iron status biomarkers; LUSC trans rs61931739 0.817 rs10743841 chr12:34252870 T/C cg24313572 chr1:56050060 NA -0.31 -6.44 -0.33 4.12e-10 Morning vs. evening chronotype; LUSC trans rs61931739 0.635 rs1352208 chr12:33932543 T/C cg13010199 chr12:38710504 ALG10B 0.4 6.03 0.31 4.29e-9 Morning vs. evening chronotype; LUSC cis rs11719291 0.833 rs11709246 chr3:48859498 G/A cg00383909 chr3:49044727 WDR6 1.27 11.48 0.53 5.96e-26 Cognitive function; LUSC cis rs10789491 1.000 rs35861275 chr1:47171909 A/C cg15501359 chr1:47185051 KIAA0494 -0.8 -10.98 -0.52 3.7e-24 Response to hepatitis C treatment; LUSC trans rs1005277 0.540 rs116205409 chr10:38478970 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -9.15 -0.45 5.6e-18 Extrinsic epigenetic age acceleration; LUSC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg08439880 chr3:133502540 NA -0.38 -6.77 -0.35 5.84e-11 Iron status biomarkers; LUSC cis rs7224314 1.000 rs57672368 chr17:65358688 G/C cg01507342 chr17:65387096 PITPNC1 -0.39 -6.86 -0.35 3.36e-11 Diisocyanate-induced asthma; LUSC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg24881330 chr22:46731750 TRMU 0.83 7.26 0.37 2.71e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg06008330 chr7:65541103 ASL -0.39 -6.03 -0.31 4.35e-9 Aortic root size; LUSC cis rs7089973 0.604 rs8181444 chr10:116588981 C/T cg23260525 chr10:116636907 FAM160B1 0.43 9.21 0.45 3.72e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg05347473 chr6:146136440 FBXO30 0.49 8.32 0.41 2.32e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg08270630 chr22:50330655 NA -0.48 -6.78 -0.35 5.4e-11 Schizophrenia; LUSC cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg12935359 chr14:103987150 CKB -0.63 -10.38 -0.49 4.61e-22 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg06784218 chr1:46089804 CCDC17 0.5 9.61 0.47 1.79e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg06784218 chr1:46089804 CCDC17 -0.58 -11.56 -0.53 3.15e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg21433313 chr16:3507492 NAT15 0.46 6.36 0.33 6.73e-10 Body mass index (adult); LUSC cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs2303282 0.933 rs4784670 chr16:56498511 G/T cg00500540 chr16:56394104 NA -0.46 -7.32 -0.37 1.89e-12 Breast cancer; LUSC trans rs7824557 0.767 rs2164272 chr8:11162496 A/C cg15556689 chr8:8085844 FLJ10661 0.54 8.26 0.41 3.34e-15 Retinal vascular caliber; LUSC cis rs1997103 0.822 rs940878 chr7:55419663 A/G cg17469321 chr7:55412551 NA 0.68 10.12 0.48 3.45e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs12579753 0.879 rs11115009 chr12:82165409 G/T cg21231944 chr12:82153410 PPFIA2 0.4 6.19 0.32 1.74e-9 Resting heart rate; LUSC cis rs11039100 0.765 rs35863959 chr11:5834622 T/A cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg23172400 chr8:95962367 TP53INP1 -0.37 -7.5 -0.38 5.92e-13 Type 2 diabetes; LUSC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03576123 chr11:487126 PTDSS2 -1.01 -10.64 -0.5 5.99e-23 Body mass index; LUSC cis rs1355223 0.573 rs1097403 chr11:34730083 C/T cg11058730 chr11:34937778 PDHX;APIP 0.43 6.12 0.32 2.61e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg24642439 chr20:33292090 TP53INP2 0.48 7.33 0.37 1.8e-12 Glomerular filtration rate (creatinine); LUSC cis rs16866061 0.962 rs16866045 chr2:225413020 G/A cg12698349 chr2:225449008 CUL3 0.87 13.93 0.61 4.35e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs7615316 0.902 rs3922730 chr3:142202857 A/T cg16271453 chr3:142027066 XRN1 -0.4 -6.86 -0.35 3.43e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs12210905 0.688 rs12194842 chr6:27367978 A/C cg08851530 chr6:28072375 NA 0.97 6.41 0.33 4.91e-10 Hip circumference adjusted for BMI; LUSC cis rs73200209 0.789 rs74420242 chr12:116551289 A/T cg01776926 chr12:116560359 MED13L -0.5 -5.99 -0.31 5.44e-9 Total body bone mineral density; LUSC cis rs10489202 1.000 rs4657727 chr1:167965241 T/C cg24449463 chr1:168025552 DCAF6 -0.58 -7.37 -0.37 1.32e-12 Schizophrenia; LUSC trans rs6828577 0.687 rs56203850 chr4:119454437 C/T cg26518628 chr1:97050305 NA -0.54 -7.85 -0.39 5.73e-14 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC cis rs6012953 1.000 rs6020563 chr20:49120395 T/G cg13958625 chr20:49123093 NA 0.31 6.57 0.34 1.92e-10 Vitiligo; LUSC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg20887711 chr4:1340912 KIAA1530 -0.49 -7.35 -0.37 1.5e-12 Obesity-related traits; LUSC cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg05707623 chr12:122985044 ZCCHC8 -0.66 -8.36 -0.42 1.67e-15 Body mass index; LUSC trans rs877282 0.898 rs11253344 chr10:765162 C/T cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs2404602 0.684 rs11072600 chr15:76867915 T/C cg23625390 chr15:77176239 SCAPER -0.67 -10.28 -0.49 9.91e-22 Blood metabolite levels; LUSC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg24690094 chr11:67383802 NA 0.41 7.98 0.4 2.39e-14 Mean corpuscular volume; LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg00431813 chr7:1051703 C7orf50 -0.46 -7.82 -0.39 7.17e-14 Longevity;Endometriosis; LUSC cis rs2559856 1.000 rs2559857 chr12:102089399 A/C cg12924262 chr12:102091054 CHPT1 0.43 6.07 0.32 3.47e-9 Blood protein levels; LUSC cis rs8141529 0.687 rs6005867 chr22:29165120 T/C cg15103426 chr22:29168792 CCDC117 0.56 7.44 0.38 8.64e-13 Lymphocyte counts; LUSC cis rs9399135 0.967 rs2183709 chr6:135377091 C/T cg22676075 chr6:135203613 NA 0.46 7.19 0.37 4.41e-12 Red blood cell count; LUSC cis rs8078723 0.966 rs2227322 chr17:38171668 C/G cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.9 -0.35 2.6e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg18180107 chr4:99064573 C4orf37 0.42 5.81 0.3 1.45e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.43 5.65 0.3 3.41e-8 Schizophrenia; LUSC cis rs7793919 0.764 rs6944865 chr7:4766383 A/T cg00064840 chr7:4784485 FOXK1 0.33 6.2 0.32 1.69e-9 Mosquito bite size; LUSC cis rs3808502 0.585 rs4549730 chr8:11239078 T/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.8 -0.3 1.56e-8 Neuroticism; LUSC cis rs870825 0.872 rs12507711 chr4:185571776 C/T cg04058563 chr4:185651563 MLF1IP 0.71 10.0 0.48 9.13e-21 Blood protein levels; LUSC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.962 rs2314130 chr20:61665129 G/T cg23505145 chr19:12996616 KLF1 0.65 11.01 0.52 2.96e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs1775715 0.677 rs2491272 chr10:32186783 A/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.65 0.34 1.17e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2279817 0.735 rs12067869 chr1:17989765 G/T cg21791023 chr1:18019539 ARHGEF10L -0.49 -6.32 -0.33 8.32e-10 Neuroticism; LUSC cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.44e-12 Motion sickness; LUSC cis rs2425143 1.000 rs6060578 chr20:34305445 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.97 -0.31 6.1e-9 Blood protein levels; LUSC cis rs7683537 0.554 rs55830081 chr4:185666477 A/C cg07424746 chr4:185654737 MLF1IP -0.49 -5.69 -0.3 2.75e-8 Systemic lupus erythematosus; LUSC cis rs1595825 0.786 rs79490184 chr2:198894219 T/A cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs9314323 0.798 rs2019239 chr8:26217354 G/A cg13160058 chr8:26243215 BNIP3L -0.39 -6.94 -0.35 2.1e-11 Red cell distribution width; LUSC cis rs4969178 0.965 rs12450500 chr17:76395750 C/T cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs7123876 0.587 rs11602616 chr11:72364077 T/C cg03713592 chr11:72463424 ARAP1 0.71 7.55 0.38 4.2e-13 Body mass index; LUSC cis rs600626 0.636 rs10793125 chr11:75452364 C/T cg24262691 chr11:75473276 NA -0.43 -6.36 -0.33 6.73e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18099408 chr3:52552593 STAB1 -0.4 -7.19 -0.37 4.15e-12 Electroencephalogram traits; LUSC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg24733560 chr20:60626293 TAF4 0.43 7.82 0.39 6.95e-14 Body mass index; LUSC cis rs2274273 0.870 rs17741831 chr14:55816715 T/A cg04306507 chr14:55594613 LGALS3 0.53 11.62 0.54 1.95e-26 Protein biomarker; LUSC cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg03264133 chr6:25882463 NA -0.52 -9.51 -0.46 3.88e-19 Blood metabolite levels; LUSC cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg18755752 chr8:142205143 DENND3 0.41 6.01 0.31 4.78e-9 Immature fraction of reticulocytes; LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg04944784 chr2:26401820 FAM59B -0.75 -10.71 -0.51 3.38e-23 Gut microbiome composition (summer); LUSC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg11244672 chr19:19639970 YJEFN3 -0.5 -6.66 -0.34 1.14e-10 Bipolar disorder; LUSC cis rs7647973 0.710 rs6446284 chr3:49616997 A/G cg03060546 chr3:49711283 APEH 0.64 6.96 0.36 1.76e-11 Menarche (age at onset); LUSC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg08270630 chr22:50330655 NA 0.41 6.05 0.31 3.98e-9 Schizophrenia; LUSC cis rs9611565 0.592 rs28750375 chr22:41990644 A/C cg03806693 chr22:41940476 POLR3H -0.91 -12.72 -0.57 1.7e-30 Vitiligo; LUSC cis rs7100689 0.556 rs3120976 chr10:82025682 C/A cg01528321 chr10:82214614 TSPAN14 0.88 13.62 0.6 6.45e-34 Post bronchodilator FEV1; LUSC cis rs17253792 0.822 rs75437558 chr14:56066798 C/T cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg05330977 chr17:18154724 FLII -0.39 -6.13 -0.32 2.53e-9 N-glycan levels; LUSC trans rs6600671 1.000 rs1856572 chr1:121169579 A/C cg00646200 chr1:148855367 NA 0.43 6.73 0.35 7.59e-11 Hip geometry; LUSC trans rs853679 1.000 rs10456362 chr6:28221816 A/G cg06606381 chr12:133084897 FBRSL1 0.59 6.99 0.36 1.54e-11 Depression; LUSC cis rs2455601 0.608 rs10840137 chr11:8890079 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -7.75 -0.39 1.12e-13 Schizophrenia; LUSC trans rs11039798 0.841 rs11039760 chr11:48479009 C/T cg15704280 chr7:45808275 SEPT13 0.73 6.2 0.32 1.66e-9 Axial length; LUSC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg11764359 chr7:65958608 NA -0.79 -12.88 -0.58 4.24e-31 Aortic root size; LUSC cis rs477692 0.905 rs563859 chr10:131417586 T/C cg11019008 chr10:131425282 MGMT 0.41 6.25 0.32 1.26e-9 Response to temozolomide; LUSC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg14159672 chr1:205819179 PM20D1 0.42 5.72 0.3 2.4e-8 Parkinson's disease; LUSC cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg24642439 chr20:33292090 TP53INP2 0.72 11.35 0.53 1.79e-25 Coronary artery disease; LUSC cis rs1790761 0.667 rs591434 chr11:67337814 C/T cg00290607 chr11:67383545 NA 0.37 6.88 0.35 3.04e-11 Mean corpuscular volume; LUSC trans rs7829975 0.688 rs7817376 chr8:8380530 C/T cg27411982 chr8:10470053 RP1L1 -0.45 -7.49 -0.38 6.39e-13 Mood instability; LUSC cis rs7107174 0.901 rs4944199 chr11:78122779 A/G cg27205649 chr11:78285834 NARS2 -0.51 -5.68 -0.3 2.9e-8 Testicular germ cell tumor; LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg13012494 chr21:47604986 C21orf56 -0.51 -7.81 -0.39 7.43e-14 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg17366294 chr4:99064904 C4orf37 0.61 10.84 0.51 1.2e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg19875535 chr5:140030758 IK -0.55 -8.95 -0.44 2.45e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg15704280 chr7:45808275 SEPT13 -0.96 -14.27 -0.62 2.14e-36 Height; LUSC cis rs13242816 1.000 rs55977427 chr7:116110768 C/T cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg07701084 chr6:150067640 NUP43 0.52 7.78 0.39 8.84e-14 Lung cancer; LUSC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.5 -6.3 -0.33 9.21e-10 Mean platelet volume; LUSC cis rs459571 1.000 rs2810489 chr9:136922700 C/T cg01294253 chr9:136912663 BRD3 0.33 5.93 0.31 7.74e-9 Platelet distribution width; LUSC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg26061582 chr7:22766209 IL6 0.48 6.98 0.36 1.63e-11 Lung cancer; LUSC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg03929089 chr4:120376271 NA -1.0 -17.6 -0.69 1.65e-49 Coronary artery disease; LUSC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg15556689 chr8:8085844 FLJ10661 -0.52 -8.2 -0.41 5.07e-15 Retinal vascular caliber; LUSC cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg01689657 chr7:91764605 CYP51A1 0.33 5.87 0.31 1.04e-8 Breast cancer; LUSC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg24397884 chr7:158709396 WDR60 0.61 9.37 0.46 1.11e-18 Height; LUSC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg07395648 chr5:131743802 NA 0.45 7.34 0.37 1.66e-12 Breast cancer;Mosquito bite size; LUSC cis rs7659604 0.540 rs10001092 chr4:122677177 C/T cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg00484396 chr16:3507460 NAT15 0.47 7.0 0.36 1.44e-11 Body mass index (adult); LUSC cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg00033643 chr7:134001901 SLC35B4 0.42 6.2 0.32 1.65e-9 Mean platelet volume; LUSC cis rs7100689 0.784 rs7089058 chr10:82071263 T/C cg01528321 chr10:82214614 TSPAN14 0.97 14.78 0.63 2.22e-38 Post bronchodilator FEV1; LUSC cis rs68170813 0.559 rs74774133 chr7:106941449 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.88 -0.48 2.31e-20 Coronary artery disease; LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs514406 0.536 rs878957 chr1:53197559 C/T cg27535305 chr1:53392650 SCP2 0.34 6.3 0.33 9.24e-10 Monocyte count; LUSC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg19748678 chr4:122722346 EXOSC9 0.74 11.31 0.53 2.42e-25 Type 2 diabetes; LUSC trans rs6601327 0.602 rs7820917 chr8:9647868 C/T cg15556689 chr8:8085844 FLJ10661 0.49 7.13 0.36 6.32e-12 Multiple myeloma (hyperdiploidy); LUSC cis rs11676348 0.873 rs10210012 chr2:219013334 G/A cg06547715 chr2:218990976 CXCR2 0.3 5.68 0.3 2.97e-8 Ulcerative colitis; LUSC cis rs4820539 1.000 rs2267003 chr22:23457098 A/G cg14186256 chr22:23484241 RTDR1 0.9 16.12 0.66 1.15e-43 Bone mineral density; LUSC cis rs710216 0.536 rs710221 chr1:43414200 G/A cg00102166 chr1:43425337 SLC2A1 -0.32 -5.68 -0.3 2.98e-8 Red cell distribution width; LUSC cis rs7267979 1.000 rs6050542 chr20:25318879 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.71e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs68170813 0.559 rs12536491 chr7:106978024 T/G cg02696742 chr7:106810147 HBP1 -0.65 -9.62 -0.47 1.71e-19 Coronary artery disease; LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg16606324 chr3:10149918 C3orf24 0.58 8.47 0.42 8.16e-16 Alzheimer's disease; LUSC cis rs3087591 1.000 rs2854331 chr17:29711728 G/A cg24425628 chr17:29625626 OMG;NF1 -0.65 -9.46 -0.46 5.51e-19 Hip circumference; LUSC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg11861562 chr11:117069780 TAGLN 0.43 7.18 0.37 4.52e-12 Blood protein levels; LUSC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg13206674 chr6:150067644 NUP43 0.57 8.82 0.43 6.37e-17 Lung cancer; LUSC trans rs853679 0.607 rs34662244 chr6:28073881 G/A cg06606381 chr12:133084897 FBRSL1 -1.05 -9.08 -0.44 9.63e-18 Depression; LUSC cis rs9517320 1.000 rs9517320 chr13:99126303 G/T cg20487152 chr13:99095054 FARP1 -0.37 -6.97 -0.36 1.7e-11 Longevity; LUSC trans rs12677056 0.739 rs62514391 chr8:113298974 T/C cg12159992 chr12:102059490 MYBPC1 0.36 6.03 0.31 4.3e-9 Peripheral artery disease; LUSC cis rs6543140 0.693 rs7579737 chr2:102987361 A/G cg09003973 chr2:102972529 NA 0.45 5.71 0.3 2.53e-8 Blood protein levels; LUSC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg14664628 chr15:75095509 CSK -0.57 -8.58 -0.42 3.72e-16 Breast cancer; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 2.93e-34 Prudent dietary pattern; LUSC cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg04511125 chr2:88470314 THNSL2 0.69 6.57 0.34 1.96e-10 Plasma clusterin levels; LUSC cis rs3820068 0.705 rs72643683 chr1:15824905 C/A cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.3 1.45e-8 Systolic blood pressure; LUSC cis rs34638657 0.872 rs2911423 chr16:82188801 C/T cg09439754 chr16:82129088 HSD17B2 -0.41 -6.56 -0.34 2.01e-10 Lung adenocarcinoma; LUSC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg03732007 chr1:2071316 PRKCZ -0.53 -9.47 -0.46 5.18e-19 Height; LUSC cis rs17270561 0.609 rs1165156 chr6:25792978 T/C cg16482183 chr6:26056742 HIST1H1C 0.53 7.53 0.38 4.66e-13 Iron status biomarkers; LUSC trans rs629535 0.773 rs655299 chr8:70074534 C/T cg21567404 chr3:27674614 NA 0.97 15.59 0.65 1.44e-41 Dupuytren's disease; LUSC cis rs9486719 0.741 rs2499799 chr6:96851676 T/C cg06623918 chr6:96969491 KIAA0776 0.74 8.64 0.43 2.34e-16 Migraine;Coronary artery disease; LUSC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg07636037 chr3:49044803 WDR6 1.05 17.35 0.69 1.61e-48 Parkinson's disease; LUSC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg05623727 chr3:50126028 RBM5 -0.35 -6.53 -0.34 2.4e-10 Intelligence (multi-trait analysis); LUSC cis rs6433857 0.627 rs6741769 chr2:181500545 G/A cg23363182 chr2:181467187 NA -0.52 -8.4 -0.42 1.28e-15 Body mass index; LUSC cis rs4971059 0.629 rs9297 chr1:155106550 A/G cg22049894 chr1:155113146 DPM3 0.39 6.2 0.32 1.66e-9 Breast cancer; LUSC cis rs9341808 0.519 rs7771593 chr6:81036127 T/C cg08355045 chr6:80787529 NA -0.44 -7.5 -0.38 5.77e-13 Sitting height ratio; LUSC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg01411255 chr17:61851458 DDX42;CCDC47 1.05 22.14 0.77 1.81e-67 Height; LUSC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg03804128 chr16:635623 NA 0.33 6.57 0.34 1.98e-10 Height; LUSC cis rs8017423 1.000 rs8017423 chr14:90679910 A/G cg04374321 chr14:90722782 PSMC1 0.73 11.59 0.54 2.57e-26 Mortality in heart failure; LUSC cis rs9287719 0.967 rs6744854 chr2:10747246 C/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.33 -0.53 2.16e-25 Alzheimer's disease; LUSC cis rs3771570 1.000 rs1056801 chr2:242292307 T/C cg21155796 chr2:242212141 HDLBP 0.63 6.76 0.35 6.25e-11 Prostate cancer; LUSC trans rs1908814 0.516 rs13281315 chr8:11794855 C/G cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.67e-16 Neuroticism; LUSC cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg22709100 chr7:91322751 NA 0.38 5.65 0.3 3.48e-8 Breast cancer; LUSC trans rs72674100 1.000 rs28483048 chr4:97990804 C/A cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg05368731 chr17:41323189 NBR1 0.85 14.27 0.62 2.14e-36 Menopause (age at onset); LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg00814883 chr7:100076585 TSC22D4 -0.73 -9.85 -0.47 2.85e-20 Platelet count; LUSC cis rs7937682 0.921 rs4616071 chr11:111440865 C/G cg09085632 chr11:111637200 PPP2R1B 0.96 13.62 0.6 6.83e-34 Primary sclerosing cholangitis; LUSC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.24e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11122272 0.735 rs2491404 chr1:231512127 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs921968 0.607 rs529474 chr2:219463283 C/T cg02176678 chr2:219576539 TTLL4 0.61 10.95 0.51 4.76e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg24596788 chr1:163392923 NA -0.45 -7.63 -0.39 2.48e-13 Motion sickness; LUSC cis rs2282032 0.527 rs3742666 chr14:90767860 T/C cg14092571 chr14:90743983 NA 0.48 8.01 0.4 1.95e-14 Longevity; LUSC cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs7523050 0.643 rs35860016 chr1:109404639 C/T cg08274380 chr1:109419600 GPSM2 1.07 10.65 0.5 5.34e-23 Fat distribution (HIV); LUSC cis rs2835872 0.965 rs702860 chr21:39008629 C/T cg20424643 chr21:39039972 KCNJ6 -0.39 -5.98 -0.31 5.89e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7945718 0.967 rs7927470 chr11:12748899 A/T cg25843174 chr11:12811716 TEAD1 0.32 7.05 0.36 1.04e-11 Educational attainment (years of education); LUSC cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs2050392 0.517 rs2480299 chr10:30743197 G/A cg18806716 chr10:30721971 MAP3K8 -0.64 -9.61 -0.47 1.86e-19 Inflammatory bowel disease; LUSC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.54 -0.46 3.12e-19 Bipolar disorder; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -7.27 -0.37 2.6e-12 Renal function-related traits (BUN); LUSC cis rs4595586 0.545 rs6580895 chr12:39372011 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.92 -0.31 7.88e-9 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg08677398 chr8:58056175 NA -0.55 -6.65 -0.34 1.22e-10 Developmental language disorder (linguistic errors); LUSC cis rs921968 0.678 rs2230115 chr2:219509618 C/A cg02176678 chr2:219576539 TTLL4 0.6 10.98 0.52 3.7e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs56283067 0.887 rs7765371 chr6:44777204 G/A cg20913747 chr6:44695427 NA -0.47 -7.08 -0.36 8.8e-12 Total body bone mineral density; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg00166722 chr3:10149974 C3orf24 0.59 7.73 0.39 1.25e-13 Alzheimer's disease; LUSC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg17366294 chr4:99064904 C4orf37 -0.6 -10.52 -0.5 1.53e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1018836 0.923 rs7840846 chr8:91565501 T/A cg16814680 chr8:91681699 NA -0.76 -12.82 -0.57 7.37e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg11584989 chr19:19387371 SF4 0.57 6.92 0.35 2.31e-11 Bipolar disorder; LUSC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg25456477 chr12:86230367 RASSF9 0.37 6.43 0.33 4.34e-10 Major depressive disorder; LUSC cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg13535736 chr9:111863775 C9orf5 -0.38 -6.1 -0.32 2.91e-9 Menarche (age at onset); LUSC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg02569458 chr12:86230093 RASSF9 0.61 10.27 0.49 1.07e-21 Major depressive disorder; LUSC cis rs10779751 0.734 rs2261217 chr1:11127764 C/A cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs56399783 0.901 rs56356906 chr7:2774383 G/A cg19731401 chr7:2775893 GNA12 0.74 8.97 0.44 2.17e-17 Childhood ear infection; LUSC cis rs6964587 1.000 rs2269727 chr7:91752690 C/A cg01689657 chr7:91764605 CYP51A1 0.34 6.1 0.32 2.9e-9 Breast cancer; LUSC trans rs208515 0.525 rs12204706 chr6:66669930 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -14.04 -0.61 1.65e-35 Exhaled nitric oxide levels; LUSC trans rs7824557 0.583 rs2263511 chr8:11233318 A/C cg15556689 chr8:8085844 FLJ10661 -0.54 -8.14 -0.41 7.68e-15 Retinal vascular caliber; LUSC cis rs2455601 1.000 rs7104661 chr11:8902501 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.56 -0.34 2e-10 Schizophrenia; LUSC trans rs11098499 0.909 rs71614422 chr4:120359340 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.55e-10 Corneal astigmatism; LUSC cis rs2839186 0.872 rs13046834 chr21:47701485 T/C cg12379764 chr21:47803548 PCNT -0.42 -5.96 -0.31 6.38e-9 Testicular germ cell tumor; LUSC cis rs5758659 0.652 rs6519301 chr22:42385967 A/G cg04733989 chr22:42467013 NAGA 0.36 5.92 0.31 7.85e-9 Cognitive function; LUSC cis rs1801251 1.000 rs4973053 chr2:233670099 G/A cg08000102 chr2:233561755 GIGYF2 -0.72 -11.93 -0.55 1.45e-27 Coronary artery disease; LUSC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.39 5.66 0.3 3.21e-8 Tonsillectomy; LUSC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg03804128 chr16:635623 NA 0.31 6.22 0.32 1.51e-9 Height; LUSC cis rs4843185 0.769 rs709805 chr16:85706564 A/G cg05245094 chr16:85669572 KIAA0182 -0.44 -6.36 -0.33 6.57e-10 Platelet distribution width; LUSC cis rs9311676 0.656 rs11917529 chr3:58382158 C/T cg26110898 chr3:58419937 PDHB 0.39 6.41 0.33 5.09e-10 Systemic lupus erythematosus; LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg22166914 chr1:53195759 ZYG11B 0.57 8.92 0.44 3.14e-17 Monocyte count; LUSC cis rs4851254 0.961 rs13000759 chr2:100753903 A/T cg07810366 chr2:100720526 AFF3 0.37 5.74 0.3 2.11e-8 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC trans rs4252134 0.959 rs4252072 chr6:161128264 A/T cg00639886 chr12:54943102 PDE1B -0.43 -6.33 -0.33 7.68e-10 Giant cell arteritis; LUSC cis rs67539049 1.000 rs73207496 chr8:11288485 T/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.42 -5.97 -0.31 6.18e-9 Itch intensity from mosquito bite; LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg16606324 chr3:10149918 C3orf24 0.59 8.6 0.43 3.15e-16 Alzheimer's disease; LUSC cis rs1801251 1.000 rs283475 chr2:233654381 A/C cg08000102 chr2:233561755 GIGYF2 -0.75 -11.84 -0.54 3.06e-27 Coronary artery disease; LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg10802521 chr3:52805072 NEK4 -0.52 -8.46 -0.42 8.21e-16 Bipolar disorder; LUSC cis rs61931739 0.534 rs1852222 chr12:34008665 C/A cg06521331 chr12:34319734 NA -0.5 -8.33 -0.41 2.06e-15 Morning vs. evening chronotype; LUSC cis rs7772486 0.846 rs2892453 chr6:146377717 C/A cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 9.38e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs2635047 0.967 rs2571016 chr18:44639175 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.48 -7.55 -0.38 4.24e-13 Educational attainment; LUSC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg22105103 chr4:187893119 NA 0.68 12.56 0.57 6.6e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg18225595 chr11:63971243 STIP1 0.51 6.33 0.33 7.83e-10 Mean platelet volume; LUSC cis rs72781680 1.000 rs7588286 chr2:24071427 A/G cg20701182 chr2:24300061 SF3B14 0.55 6.02 0.31 4.59e-9 Lymphocyte counts; LUSC trans rs11098499 0.954 rs6834796 chr4:120414693 A/C cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg01579765 chr21:45077557 HSF2BP -0.53 -11.35 -0.53 1.84e-25 Mean corpuscular volume; LUSC cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg00852783 chr1:26633632 UBXN11 0.6 9.59 0.46 2.2e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg14159672 chr1:205819179 PM20D1 0.78 14.67 0.63 5.9e-38 Monocyte percentage of white cells; LUSC cis rs17270561 0.609 rs7450798 chr6:25719280 T/A cg17691542 chr6:26056736 HIST1H1C 0.56 7.84 0.39 6.09e-14 Iron status biomarkers; LUSC cis rs1904096 0.506 rs12511433 chr4:95162425 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.23 -0.41 4.39e-15 Type 2 diabetes; LUSC cis rs9473147 0.516 rs9367284 chr6:47516369 A/G cg02130027 chr6:47444894 CD2AP 0.36 5.74 0.3 2.09e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg27535305 chr1:53392650 SCP2 0.36 6.66 0.34 1.13e-10 Monocyte count; LUSC trans rs1493916 0.905 rs34910379 chr18:31400047 A/G cg13755796 chr4:20253514 NA -0.43 -6.62 -0.34 1.43e-10 Life satisfaction; LUSC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg06108461 chr20:60628389 TAF4 -1.01 -17.17 -0.68 8.19e-48 Body mass index; LUSC cis rs8017423 0.935 rs8012299 chr14:90715822 G/T cg14092571 chr14:90743983 NA -0.36 -5.9 -0.31 8.93e-9 Mortality in heart failure; LUSC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg12463550 chr7:65579703 CRCP -0.63 -5.69 -0.3 2.82e-8 Diabetic kidney disease; LUSC cis rs3733418 0.929 rs13149738 chr4:165905697 T/C cg11630554 chr4:165878136 TRIM61;C4orf39 -0.51 -5.83 -0.3 1.34e-8 Obesity-related traits; LUSC cis rs9399135 0.967 rs4896119 chr6:135293391 C/T cg22676075 chr6:135203613 NA 0.47 7.41 0.38 1.03e-12 Red blood cell count; LUSC cis rs12677618 1.000 rs12677618 chr8:142302024 C/T cg27411547 chr8:142287226 NA -0.4 -6.37 -0.33 6.18e-10 Plateletcrit; LUSC cis rs868036 0.681 rs2241423 chr15:68086838 G/A cg24579218 chr15:68104479 NA -0.37 -6.58 -0.34 1.79e-10 Restless legs syndrome; LUSC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg22903471 chr2:27725779 GCKR -0.41 -6.92 -0.35 2.29e-11 Total body bone mineral density; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.14e-9 Menopause (age at onset); LUSC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg14541582 chr5:601475 NA -0.37 -5.71 -0.3 2.48e-8 Lung disease severity in cystic fibrosis; LUSC cis rs7923609 0.749 rs12247907 chr10:65317045 G/C cg01631684 chr10:65280961 REEP3 0.41 6.05 0.31 3.84e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11644478 chr21:40555479 PSMG1 -0.69 -10.88 -0.51 8.71e-24 Menarche (age at onset); LUSC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg06740227 chr12:86229804 RASSF9 0.45 7.31 0.37 1.98e-12 Major depressive disorder; LUSC cis rs262150 0.714 rs2657397 chr7:158785095 C/T cg12590608 chr7:158785262 NA 0.31 5.92 0.31 8.17e-9 Facial morphology (factor 20); LUSC cis rs12949688 0.967 rs9905938 chr17:55824351 G/A cg12582317 chr17:55822272 NA 0.31 5.69 0.3 2.83e-8 Schizophrenia; LUSC cis rs8018808 0.935 rs17824316 chr14:77930407 G/A cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg20135002 chr11:47629003 NA -0.5 -7.82 -0.39 7.16e-14 Subjective well-being; LUSC cis rs9650657 0.711 rs35091929 chr8:10693492 T/C cg27411982 chr8:10470053 RP1L1 -0.39 -6.34 -0.33 7.62e-10 Neuroticism; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg20295408 chr7:1910781 MAD1L1 -0.47 -6.7 -0.34 9.07e-11 Bipolar disorder and schizophrenia; LUSC cis rs7224314 1.000 rs62084082 chr17:65388046 A/G cg01507342 chr17:65387096 PITPNC1 -0.44 -7.72 -0.39 1.37e-13 Diisocyanate-induced asthma; LUSC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg20891283 chr12:69753455 YEATS4 0.65 10.16 0.49 2.71e-21 Blood protein levels; LUSC cis rs6692729 0.966 rs1150900 chr1:227045029 A/G cg10327440 chr1:227177885 CDC42BPA 0.5 7.23 0.37 3.26e-12 Electrodermal activity; LUSC cis rs7481584 0.624 rs375579 chr11:3065300 G/C cg05729581 chr11:3078854 CARS 0.4 5.93 0.31 7.76e-9 Calcium levels; LUSC cis rs7474896 0.583 rs11011341 chr10:37998500 G/A cg25427524 chr10:38739819 LOC399744 -0.5 -6.88 -0.35 3e-11 Obesity (extreme); LUSC trans rs66887589 0.616 rs1052633 chr4:120215314 A/G cg25214090 chr10:38739885 LOC399744 0.39 6.11 0.32 2.83e-9 Diastolic blood pressure; LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg08280861 chr8:58055591 NA 0.58 7.09 0.36 8.24e-12 Developmental language disorder (linguistic errors); LUSC cis rs12893668 0.645 rs12889403 chr14:104034746 C/T cg04998671 chr14:104000505 TRMT61A -0.47 -6.64 -0.34 1.25e-10 Reticulocyte count; LUSC cis rs4280164 0.945 rs2281472 chr14:24775846 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 0.58 7.48 0.38 6.5e-13 Parent of origin effect on language impairment (paternal); LUSC cis rs427941 0.703 rs201449 chr7:101739054 A/G cg06246474 chr7:101738831 CUX1 0.38 6.33 0.33 7.73e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs9517320 0.534 rs4771306 chr13:99143661 T/C cg07423050 chr13:99094983 FARP1 -0.56 -10.86 -0.51 1.02e-23 Longevity; LUSC cis rs11190604 1.000 rs2495741 chr10:102331795 A/G cg07080220 chr10:102295463 HIF1AN 0.66 9.06 0.44 1.13e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6547741 1.000 rs6547734 chr2:27830990 G/T cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 2.94e-39 Oral cavity cancer; LUSC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg00933542 chr6:150070202 PCMT1 0.32 6.49 0.33 3.09e-10 Lung cancer; LUSC cis rs3820928 0.874 rs7576081 chr2:227843634 C/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.41 -0.38 1.02e-12 Pulmonary function; LUSC cis rs6542838 0.597 rs35107109 chr2:99386210 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.32 -0.33 8.16e-10 Fear of minor pain; LUSC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg21017887 chr14:105400489 NA 0.69 13.21 0.59 2.42e-32 Rheumatoid arthritis; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 2.95e-13 Prudent dietary pattern; LUSC trans rs77372450 0.551 rs10866685 chr5:157104711 G/A cg10450108 chr5:140208893 PCDHA6;PCDHA2;PCDHA1;PCDHA5;PCDHA3;PCDHA4 -0.53 -5.97 -0.31 6.18e-9 Bipolar disorder (body mass index interaction); LUSC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg14895029 chr7:2775587 GNA12 -0.37 -5.99 -0.31 5.5e-9 Height; LUSC cis rs6460942 0.591 rs4721079 chr7:12337742 A/G cg06484146 chr7:12443880 VWDE -0.58 -6.2 -0.32 1.67e-9 Coronary artery disease; LUSC cis rs6546537 0.513 rs34878028 chr2:69891422 A/G cg10773587 chr2:69614142 GFPT1 -0.35 -5.73 -0.3 2.23e-8 Serum thyroid-stimulating hormone levels; LUSC cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg13395646 chr4:1353034 KIAA1530 -0.58 -9.15 -0.45 5.94e-18 Obesity-related traits; LUSC cis rs17255340 0.520 rs1170504 chr6:83993569 A/C cg08257003 chr6:84140564 ME1 0.32 7.89 0.4 4.39e-14 Platelet-derived growth factor BB levels; LUSC cis rs11098499 0.954 rs28572238 chr4:120316686 T/G cg09307838 chr4:120376055 NA 0.79 11.36 0.53 1.63e-25 Corneal astigmatism; LUSC trans rs8072100 0.875 rs4794047 chr17:45763005 A/T cg04995722 chr7:26192034 NFE2L3 0.38 6.28 0.32 1.07e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1775715 0.705 rs2778651 chr10:32106575 C/T cg03015672 chr10:32216066 ARHGAP12 0.35 6.15 0.32 2.23e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg06873352 chr17:61820015 STRADA 0.7 12.66 0.57 2.96e-30 Prudent dietary pattern; LUSC cis rs72781680 1.000 rs7594510 chr2:24173377 A/G cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs6599077 0.950 rs9867011 chr3:40105468 T/A cg13683864 chr3:40499215 RPL14 -0.61 -7.6 -0.38 2.94e-13 Sleep-related phenotypes; LUSC cis rs2236918 0.710 rs1776130 chr1:242023362 A/G cg17736920 chr1:242011382 EXO1 0.43 6.84 0.35 3.85e-11 Menopause (age at onset); LUSC cis rs28735056 0.596 rs3744879 chr18:77679006 G/C cg20368463 chr18:77673604 PQLC1 -0.73 -11.47 -0.53 6.41e-26 Schizophrenia; LUSC cis rs4363385 0.588 rs11586559 chr1:153025714 G/A cg25856811 chr1:152973957 SPRR3 -0.37 -6.04 -0.31 4.08e-9 Inflammatory skin disease; LUSC cis rs11122272 0.701 rs2011383 chr1:231479788 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.07 -0.48 5.45e-21 Hemoglobin concentration; LUSC cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg21545522 chr1:205238299 TMCC2 0.51 9.63 0.47 1.6e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10140922 0.966 rs4982260 chr14:35822105 T/A cg07166546 chr14:35805898 NA -0.24 -5.89 -0.31 9.53e-9 Hip circumference adjusted for BMI; LUSC cis rs7215564 0.908 rs2340770 chr17:78754770 T/C cg23238734 chr17:78661607 RPTOR -0.44 -5.65 -0.3 3.4e-8 Myopia (pathological); LUSC cis rs2176263 0.900 rs6756419 chr2:24126904 A/G cg08063864 chr2:24346004 PFN4;LOC375190 -0.42 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg23711669 chr6:146136114 FBXO30 0.86 16.03 0.66 2.84e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25716786 chr12:498630 KDM5A;CCDC77 0.41 6.2 0.32 1.65e-9 Triglycerides; LUSC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg23283495 chr1:209979779 IRF6 0.59 8.36 0.42 1.66e-15 Cleft lip with or without cleft palate; LUSC cis rs9503598 0.610 rs1328687 chr6:3468377 A/C cg00476032 chr6:3446245 SLC22A23 0.31 6.07 0.32 3.52e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs4363385 0.747 rs946097 chr1:152974732 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.71 -0.39 1.44e-13 Inflammatory skin disease; LUSC cis rs7582180 0.625 rs11892034 chr2:100938952 T/C cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg26501027 chr6:150326334 RAET1K 0.43 6.32 0.33 8.48e-10 Triglycerides; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg16606324 chr3:10149918 C3orf24 0.64 9.55 0.46 2.89e-19 Alzheimer's disease; LUSC cis rs12549902 0.800 rs7825337 chr8:41507237 C/T cg21772509 chr8:41503840 NKX6-3 0.69 11.4 0.53 1.19e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs80130819 0.591 rs17122651 chr12:48496660 C/T cg24011408 chr12:48396354 COL2A1 -0.46 -6.13 -0.32 2.42e-9 Prostate cancer; LUSC cis rs1371867 0.875 rs1660320 chr8:101337579 A/C cg00191853 chr8:101177733 SPAG1 -0.36 -6.03 -0.31 4.39e-9 Atrioventricular conduction; LUSC cis rs6681460 0.932 rs659291 chr1:67180746 A/C cg02459107 chr1:67143332 SGIP1 0.48 8.97 0.44 2.24e-17 Presence of antiphospholipid antibodies; LUSC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.04e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs62055045 0.528 rs62053065 chr16:71557806 G/A cg15281710 chr15:96890452 NA -0.46 -6.39 -0.33 5.69e-10 Schizophrenia; LUSC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg05043794 chr9:111880884 C9orf5 0.34 7.63 0.39 2.45e-13 Menarche (age at onset); LUSC cis rs1904096 0.506 rs2865350 chr4:95212813 A/T cg11021082 chr4:95130006 SMARCAD1 0.37 6.31 0.33 8.96e-10 Type 2 diabetes; LUSC cis rs4400599 0.642 rs4364874 chr1:154167788 C/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.76 -0.3 1.87e-8 Platelet distribution width; LUSC cis rs9300255 0.544 rs1790100 chr12:123656725 G/T cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.21 -0.32 1.62e-9 Neutrophil percentage of white cells; LUSC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -6.08 -0.32 3.35e-9 Developmental language disorder (linguistic errors); LUSC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg09455208 chr3:40491958 NA 0.57 10.26 0.49 1.2e-21 Renal cell carcinoma; LUSC cis rs739401 0.611 rs402276 chr11:3051404 C/G cg25174290 chr11:3078921 CARS 0.59 9.29 0.45 2.09e-18 Longevity; LUSC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg13939156 chr17:80058883 NA -0.34 -6.76 -0.35 6.08e-11 Life satisfaction; LUSC cis rs3857536 0.813 rs1029399 chr6:66952476 G/C cg07460842 chr6:66804631 NA -0.46 -6.36 -0.33 6.75e-10 Blood trace element (Cu levels); LUSC cis rs4363385 0.818 rs409986 chr1:153014741 A/C cg00922841 chr1:152955080 SPRR1A 0.45 7.96 0.4 2.72e-14 Inflammatory skin disease; LUSC cis rs4285028 0.948 rs34181646 chr3:121705373 T/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -9.12 -0.45 6.98e-18 Multiple sclerosis; LUSC cis rs8072100 0.934 rs8067286 chr17:45594590 A/G cg08085267 chr17:45401833 C17orf57 0.59 9.76 0.47 5.98e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg09375892 chr17:708413 NXN -0.38 -6.33 -0.33 7.91e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs2985684 0.947 rs1952013 chr14:50087357 C/G cg04989706 chr14:50066350 PPIL5 -0.45 -5.81 -0.3 1.43e-8 Carotid intima media thickness; LUSC cis rs7267979 1.000 rs2387884 chr20:25379069 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1692580 0.870 rs263533 chr1:2163568 C/T cg03732007 chr1:2071316 PRKCZ 0.36 5.87 0.31 1.05e-8 Coronary artery disease; LUSC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg09238746 chr17:78121135 EIF4A3 0.98 15.7 0.65 5.46e-42 Yeast infection; LUSC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.64 0.34 1.3100000000000001e-10 Lung cancer; LUSC cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.97 0.36 1.74e-11 Multiple sclerosis; LUSC cis rs9341808 0.718 rs9294171 chr6:80839815 C/T cg08355045 chr6:80787529 NA 0.55 9.7 0.47 9.18e-20 Sitting height ratio; LUSC cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg26384229 chr12:38710491 ALG10B 0.89 15.04 0.64 2.16e-39 Bladder cancer; LUSC cis rs2273669 0.667 rs12198182 chr6:109318704 T/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs9467773 0.620 rs2494701 chr6:26634432 C/T cg05738196 chr6:26577821 NA 0.78 14.95 0.63 4.82e-39 Intelligence (multi-trait analysis); LUSC cis rs2230307 0.536 rs580611 chr1:100622925 G/A cg24955406 chr1:100503596 HIAT1 -0.6 -6.43 -0.33 4.34e-10 Carotid intima media thickness; LUSC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg02807482 chr3:125708958 NA -0.51 -6.37 -0.33 6.45e-10 Blood pressure (smoking interaction); LUSC cis rs9611565 0.592 rs5751129 chr22:42015765 C/T cg03806693 chr22:41940476 POLR3H 0.91 12.83 0.57 6.85e-31 Vitiligo; LUSC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg15445000 chr17:37608096 MED1 0.37 6.53 0.34 2.48e-10 Glomerular filtration rate (creatinine); LUSC cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs3741151 0.773 rs73544716 chr11:73170061 C/T cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs6456156 0.586 rs911632 chr6:167471461 T/C cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg13607699 chr17:42295918 UBTF 0.66 9.95 0.48 1.33e-20 Total body bone mineral density; LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg08219700 chr8:58056026 NA 0.69 7.91 0.4 3.7e-14 Developmental language disorder (linguistic errors); LUSC trans rs9388451 0.872 rs2008027 chr6:126052359 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -9.17 -0.45 4.86e-18 Brugada syndrome; LUSC cis rs9486715 1.000 rs9486725 chr6:97061159 C/T cg06623918 chr6:96969491 KIAA0776 -0.87 -14.53 -0.62 2.02e-37 Headache; LUSC cis rs7527798 0.592 rs960088 chr1:207827067 A/C cg09232269 chr1:207846808 CR1L -0.3 -6.39 -0.33 5.46e-10 Erythrocyte sedimentation rate; LUSC cis rs7560272 0.723 rs12995433 chr2:73641326 C/T cg20560298 chr2:73613845 ALMS1 0.46 7.19 0.37 4.3e-12 Schizophrenia; LUSC cis rs12995849 0.714 rs6543342 chr2:106462256 T/C cg14210321 chr2:106509881 NCK2 -0.42 -5.96 -0.31 6.3e-9 Addiction; LUSC cis rs1577917 0.958 rs36053156 chr6:86575509 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.65 -9.2 -0.45 3.85e-18 Response to antipsychotic treatment; LUSC cis rs2295359 0.892 rs12401432 chr1:67656931 C/G cg12940439 chr1:67600707 NA 0.38 6.16 0.32 2.11e-9 Psoriasis; LUSC cis rs2841277 0.646 rs2819419 chr14:105406238 A/C cg14403583 chr14:105418241 AHNAK2 -0.6 -9.9 -0.48 1.93e-20 Rheumatoid arthritis; LUSC cis rs7712401 0.755 rs3213794 chr5:122161638 A/C cg19077854 chr5:122220652 SNX24 0.36 8.13 0.41 8.68e-15 Mean platelet volume; LUSC trans rs9467603 0.925 rs4712969 chr6:25764192 A/G cg06606381 chr12:133084897 FBRSL1 0.58 6.07 0.32 3.57e-9 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg12927641 chr6:109611667 NA -0.37 -6.2 -0.32 1.66e-9 Reticulocyte fraction of red cells; LUSC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg00129232 chr17:37814104 STARD3 -0.49 -7.32 -0.37 1.91e-12 Asthma; LUSC cis rs2046867 0.818 rs6792109 chr3:72867091 C/T cg25664220 chr3:72788482 NA -0.67 -11.85 -0.54 2.77e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs12682352 0.652 rs1567398 chr8:8726804 A/C cg21775007 chr8:11205619 TDH -0.47 -6.87 -0.35 3.17e-11 Neuroticism; LUSC cis rs11098499 0.754 rs1814813 chr4:120258207 G/T cg09307838 chr4:120376055 NA -0.7 -10.92 -0.51 6.26e-24 Corneal astigmatism; LUSC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.91 -0.51 6.58e-24 Schizophrenia; LUSC cis rs2086824 0.702 rs3114891 chr16:89399455 A/G cg00750074 chr16:89608354 SPG7 -0.4 -6.72 -0.35 7.68e-11 Multiple myeloma (IgH translocation); LUSC cis rs11603020 0.904 rs11606677 chr11:57383377 G/A cg23127183 chr11:57508653 C11orf31 -0.47 -6.57 -0.34 1.95e-10 Blood protein levels; LUSC cis rs10089 1.000 rs1560636 chr5:127447987 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.08 0.55 4.06e-28 Ileal carcinoids; LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg07677032 chr17:61819896 STRADA 0.52 8.46 0.42 8.48e-16 Prudent dietary pattern; LUSC trans rs6598955 0.671 rs11247908 chr1:26638222 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.14 -0.41 8.17e-15 Obesity-related traits; LUSC cis rs2540226 0.935 rs917963 chr2:39966537 C/A cg23576258 chr2:39999331 THUMPD2 0.35 5.92 0.31 8.12e-9 Personality dimensions; LUSC cis rs17255340 0.539 rs1145896 chr6:84041599 G/T cg08257003 chr6:84140564 ME1 0.34 8.23 0.41 4.19e-15 Platelet-derived growth factor BB levels; LUSC cis rs11190604 1.000 rs2489045 chr10:102344754 C/T cg16342193 chr10:102329863 NA -0.39 -6.93 -0.35 2.14e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs72781680 1.000 rs72796329 chr2:24141912 G/A cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs6681460 0.932 rs2146904 chr1:67160336 C/T cg02459107 chr1:67143332 SGIP1 -0.44 -8.12 -0.41 8.89e-15 Presence of antiphospholipid antibodies; LUSC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg22823121 chr1:150693482 HORMAD1 0.49 6.97 0.36 1.7e-11 Melanoma; LUSC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg24110177 chr3:50126178 RBM5 0.65 11.68 0.54 1.14e-26 Body mass index; LUSC cis rs2573652 1.000 rs2573652 chr15:100514614 A/G cg09918751 chr15:100517450 ADAMTS17 -0.38 -6.93 -0.35 2.12e-11 Height; LUSC trans rs11088226 0.758 rs2833864 chr21:33888393 A/C cg09050820 chr6:167586206 TCP10L2 0.48 6.52 0.34 2.65e-10 Gastritis; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg14282440 chr2:27593116 EIF2B4;SNX17 0.38 5.99 0.31 5.44e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC trans rs2243480 0.901 rs313808 chr7:65499873 T/G cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.64e-15 Diabetic kidney disease; LUSC cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg25554036 chr4:6271136 WFS1 0.58 11.43 0.53 9.34e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg27170947 chr2:26402098 FAM59B -0.69 -10.55 -0.5 1.2e-22 Gut microbiome composition (summer); LUSC cis rs1267303 0.642 rs114746843 chr1:46999239 C/A cg25110126 chr1:46999211 NA 0.77 11.11 0.52 1.28e-24 Monobrow; LUSC cis rs7615952 0.673 rs9289270 chr3:125636979 A/T cg05084668 chr3:125655381 ALG1L -0.92 -13.12 -0.58 5.09e-32 Blood pressure (smoking interaction); LUSC trans rs1728785 0.892 rs1170427 chr16:68603852 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.71 -0.3 2.55e-8 Life satisfaction; LUSC cis rs4845570 0.920 rs3811414 chr1:151763246 A/G cg07092448 chr1:151763213 TDRKH -1.22 -16.88 -0.68 1.2e-46 Coronary artery disease; LUSC cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg24692254 chr21:30365293 RNF160 -0.92 -19.39 -0.73 1.26e-56 Dental caries; LUSC cis rs3849570 0.555 rs6548783 chr3:81993621 G/A cg07356753 chr3:81810745 GBE1 -0.42 -5.92 -0.31 7.89e-9 Waist circumference;Body mass index; LUSC cis rs1577917 1.000 rs1415753 chr6:86753074 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.73 -0.35 7.56e-11 Response to antipsychotic treatment; LUSC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.48 -0.38 6.59e-13 Menarche (age at onset); LUSC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.54 0.38 4.59e-13 Cognitive function; LUSC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg11843238 chr5:131593191 PDLIM4 0.38 6.55 0.34 2.16e-10 Breast cancer; LUSC cis rs1775715 0.737 rs2799015 chr10:32107712 C/T cg03015672 chr10:32216066 ARHGAP12 0.35 6.15 0.32 2.23e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6582630 0.537 rs66855609 chr12:38299029 T/C cg26384229 chr12:38710491 ALG10B 0.87 14.84 0.63 1.29e-38 Drug-induced liver injury (flucloxacillin); LUSC trans rs11098499 0.820 rs2389885 chr4:120533931 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.03 0.31 4.34e-9 Corneal astigmatism; LUSC cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg26597838 chr10:835615 NA 0.92 12.43 0.56 2.03e-29 Eosinophil percentage of granulocytes; LUSC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.55e-10 Life satisfaction; LUSC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs9326248 0.520 rs7127881 chr11:116880798 G/A cg11861562 chr11:117069780 TAGLN 0.32 6.22 0.32 1.45e-9 Blood protein levels; LUSC cis rs11809207 1.000 rs11809207 chr1:26521140 G/A cg00147160 chr1:26503991 CNKSR1 0.42 7.02 0.36 1.28e-11 Height; LUSC cis rs11030122 0.673 rs10835474 chr11:4020819 G/T cg18678763 chr11:4115507 RRM1 -0.45 -5.9 -0.31 9.07e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.28 0.41 2.99e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs79839061 0.610 rs73207794 chr4:872020 T/C cg14530993 chr4:882597 GAK 0.72 7.45 0.38 7.91e-13 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg18402987 chr7:1209562 NA 0.63 6.91 0.35 2.41e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg07828024 chr6:149772892 ZC3H12D -0.37 -7.91 -0.4 3.84e-14 Dupuytren's disease; LUSC cis rs7577851 0.715 rs6729268 chr2:69623932 C/T cg10773587 chr2:69614142 GFPT1 0.56 6.3 0.33 9.29e-10 Parkinson's disease (age of onset); LUSC cis rs4964805 1.000 rs1866295 chr12:104186946 G/T cg02344784 chr12:104178138 NT5DC3 0.45 7.14 0.36 5.88e-12 Attention deficit hyperactivity disorder; LUSC cis rs2742417 1.000 rs2742432 chr3:45737467 G/T cg09608765 chr3:45636137 LIMD1 -0.37 -7.2 -0.37 4.14e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg02753203 chr1:228287806 NA -0.65 -10.95 -0.51 4.75e-24 Diastolic blood pressure; LUSC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.63 9.71 0.47 8.69e-20 Cognitive test performance; LUSC cis rs7772486 0.846 rs1474871 chr6:146406294 G/A cg05347473 chr6:146136440 FBXO30 0.49 8.13 0.41 8.58e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs12900413 0.645 rs28507224 chr15:90305393 T/C cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.4e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs4363385 0.574 rs61813182 chr1:152943868 T/A cg00922841 chr1:152955080 SPRR1A -0.36 -6.05 -0.31 3.88e-9 Inflammatory skin disease; LUSC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg24397884 chr7:158709396 WDR60 0.64 9.86 0.47 2.7e-20 Height; LUSC cis rs11229555 0.874 rs7102852 chr11:58358348 G/A cg15696309 chr11:58395628 NA -0.71 -9.15 -0.45 5.57e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs61931739 0.890 rs1849160 chr12:34140191 A/G cg06521331 chr12:34319734 NA -0.36 -6.03 -0.31 4.41e-9 Morning vs. evening chronotype; LUSC cis rs7095944 0.614 rs10901816 chr10:126440395 G/A cg08799069 chr10:126477246 METTL10 -0.41 -6.31 -0.33 9.12e-10 Asthma; LUSC cis rs7131987 0.650 rs7311912 chr12:29475703 G/C cg09582351 chr12:29534625 ERGIC2 -0.33 -6.77 -0.35 5.69e-11 QT interval; LUSC cis rs425277 1.000 rs262670 chr1:2082458 C/T cg24578937 chr1:2090814 PRKCZ 0.6 13.93 0.61 4.18e-35 Height; LUSC cis rs11785400 1.000 rs4736365 chr8:143742197 A/G cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg00343986 chr7:65444356 GUSB -0.43 -6.63 -0.34 1.32e-10 Aortic root size; LUSC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg22823121 chr1:150693482 HORMAD1 -0.53 -7.54 -0.38 4.36e-13 Urate levels; LUSC cis rs61931739 0.500 rs11519123 chr12:34436478 A/G cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC cis rs7589728 0.844 rs2363010 chr2:88496399 G/C cg04511125 chr2:88470314 THNSL2 0.68 6.33 0.33 7.78e-10 Plasma clusterin levels; LUSC cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.65 8.48 0.42 7.37e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12118280 0.612 rs591141 chr1:108694894 A/G cg11967332 chr1:108735228 SLC25A24 0.54 7.27 0.37 2.49e-12 Myeloid white cell count; LUSC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg20821713 chr7:1055600 C7orf50 -0.52 -6.9 -0.35 2.64e-11 Bronchopulmonary dysplasia; LUSC cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg15997130 chr1:24165203 NA -0.47 -7.0 -0.36 1.38e-11 Immature fraction of reticulocytes; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 2.92e-13 Prudent dietary pattern; LUSC cis rs4853525 0.522 rs6434412 chr2:191585275 A/G cg11845111 chr2:191398756 TMEM194B -0.42 -5.72 -0.3 2.32e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg25036284 chr2:26402008 FAM59B -0.69 -9.58 -0.46 2.38e-19 Gut microbiome composition (summer); LUSC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg13010344 chr12:123464640 ARL6IP4 -0.47 -7.1 -0.36 7.72e-12 Neutrophil percentage of white cells; LUSC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.88 0.44 4.2e-17 Schizophrenia; LUSC cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs7000551 0.715 rs2443502 chr8:22340499 G/A cg12081754 chr8:22256438 SLC39A14 0.47 7.22 0.37 3.53e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.68 -10.69 -0.5 3.91e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2692947 0.711 rs34639392 chr2:96508976 T/C cg22654517 chr2:96458247 NA 0.37 7.45 0.38 7.96e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg21862992 chr11:68658383 NA 0.51 8.19 0.41 5.71e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs979233 0.502 rs276268 chr5:42072852 A/G cg07010552 chr17:7358735 CHRNB1 -0.41 -5.98 -0.31 5.65e-9 Systemic lupus erythematosus; LUSC cis rs8060686 0.668 rs8046355 chr16:68205214 T/A cg26727032 chr16:67993705 SLC12A4 -0.4 -5.98 -0.31 5.79e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg21856205 chr7:94953877 PON1 -0.36 -5.82 -0.3 1.37e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs28735056 0.933 rs499472 chr18:77589759 C/T cg05926928 chr17:57297772 GDPD1 -0.48 -6.71 -0.34 8.57e-11 Schizophrenia; LUSC cis rs6445967 1.000 rs6777105 chr3:58307644 A/G cg23715586 chr3:58305044 RPP14 0.5 10.02 0.48 7.67e-21 Platelet count; LUSC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08109568 chr15:31115862 NA -0.59 -8.24 -0.41 3.89e-15 Huntington's disease progression; LUSC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg08847533 chr14:75593920 NEK9 0.86 16.21 0.66 5.23e-44 Height; LUSC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg03676636 chr4:99064102 C4orf37 0.36 7.99 0.4 2.18e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs3736594 0.607 rs7584462 chr2:28176056 A/T cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.89e-11 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC trans rs11098499 0.863 rs3822195 chr4:120471660 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC trans rs62103177 0.733 rs62103232 chr18:77635553 G/A cg05926928 chr17:57297772 GDPD1 1.56 18.18 0.71 8.12e-52 Opioid sensitivity; LUSC cis rs9747201 1.000 rs9303020 chr17:80163247 C/T cg18209359 chr17:80159595 CCDC57 -0.36 -6.13 -0.32 2.41e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.79 14.41 0.62 6.29e-37 Total body bone mineral density; LUSC cis rs2486288 0.656 rs12904150 chr15:45547605 T/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.01 -0.4 1.89e-14 Glomerular filtration rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06888415 chr1:150336129 RPRD2 -0.42 -6.13 -0.32 2.47e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6480314 0.542 rs17231630 chr10:70028717 G/A cg04882175 chr6:131122610 NA -0.54 -6.32 -0.33 8.24e-10 Optic nerve measurement (disc area); LUSC cis rs75804782 0.641 rs41264155 chr2:239342096 G/A cg18131467 chr2:239335373 ASB1 -0.77 -6.63 -0.34 1.3100000000000001e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs9400467 0.528 rs110732 chr6:111679869 G/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg17063962 chr7:91808500 NA -0.59 -9.29 -0.45 1.98e-18 Breast cancer; LUSC cis rs17030434 1.000 rs952211 chr4:154717816 A/G cg14289246 chr4:154710475 SFRP2 -0.46 -5.7 -0.3 2.68e-8 Electrocardiographic conduction measures; LUSC cis rs12618769 0.597 rs3769727 chr2:99103318 C/T cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs6121246 0.567 rs6087700 chr20:30217560 A/G cg21427119 chr20:30132790 HM13 -0.43 -6.1 -0.32 3.01e-9 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs1949733 0.523 rs16842557 chr4:8543985 C/T cg13073564 chr4:8508604 NA 0.34 6.22 0.32 1.49e-9 Response to antineoplastic agents; LUSC cis rs10761482 0.500 rs10821790 chr10:62288767 T/C cg18175470 chr10:62150864 ANK3 -0.51 -7.38 -0.37 1.25e-12 Schizophrenia; LUSC cis rs11955175 0.717 rs41271053 chr5:40835393 A/C cg04002187 chr5:40835754 RPL37 0.71 5.89 0.31 9.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg08847533 chr14:75593920 NEK9 -0.82 -14.77 -0.63 2.41e-38 Height; LUSC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.55 8.3 0.41 2.54e-15 Lymphocyte counts; LUSC cis rs7267979 0.966 rs2424715 chr20:25420077 A/G cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.83 -0.57 6.66e-31 Chronic sinus infection; LUSC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg16928487 chr17:17741425 SREBF1 0.46 9.23 0.45 3.28e-18 Total body bone mineral density; LUSC cis rs11039100 0.573 rs11038951 chr11:5780343 G/C cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs890100 0.673 rs13424976 chr2:56658363 A/G cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.75e-9 Gut microbiome composition (summer); LUSC cis rs5758511 0.514 rs5751211 chr22:42486056 G/A cg00645731 chr22:42541494 CYP2D7P1 0.6 10.05 0.48 6.31e-21 Birth weight; LUSC cis rs9463078 0.585 rs718112 chr6:44859451 T/G cg25276700 chr6:44698697 NA 0.29 5.88 0.31 1.01e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7896691 0.925 rs6602023 chr10:3155217 A/G cg15228268 chr10:3146741 PFKP -0.57 -5.67 -0.3 3.15e-8 Disc degeneration (lumbar); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05515713 chr2:10262434 RRM2 -0.41 -5.97 -0.31 6.22e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg12311346 chr5:56204834 C5orf35 -0.57 -8.28 -0.41 3.05e-15 Coronary artery disease; LUSC cis rs2073300 1.000 rs6137962 chr20:23443966 T/C cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6541297 0.699 rs4846916 chr1:230296492 G/A cg20703242 chr1:230279135 GALNT2 0.5 5.72 0.3 2.33e-8 Coronary artery disease; LUSC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg07936489 chr17:37558343 FBXL20 0.71 9.91 0.48 1.88e-20 Glomerular filtration rate (creatinine); LUSC cis rs231513 0.954 rs231501 chr17:41972303 C/T cg26893861 chr17:41843967 DUSP3 -0.5 -6.07 -0.32 3.42e-9 Cognitive function; LUSC cis rs9905704 0.633 rs2531731 chr17:56546524 A/C cg19466818 chr17:56409534 MIR142 0.37 6.65 0.34 1.23e-10 Testicular germ cell tumor; LUSC trans rs7647973 0.626 rs11720705 chr3:49753788 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -6.8 -0.35 4.81e-11 Menarche (age at onset); LUSC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC trans rs2840044 1.000 rs11656138 chr17:33910218 T/C cg19694781 chr19:47549865 TMEM160 0.58 9.39 0.46 9.66e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs929354 1.000 rs929354 chr7:157045557 C/T cg05182265 chr7:156933206 UBE3C 0.44 6.66 0.34 1.15e-10 Body mass index; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 19.53 0.73 3.44e-57 Prudent dietary pattern; LUSC cis rs2073300 0.609 rs56334525 chr20:23365812 A/G cg12062639 chr20:23401060 NAPB 0.93 8.07 0.4 1.27e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg13607699 chr17:42295918 UBTF 0.77 14.39 0.62 7.01e-37 Total body bone mineral density; LUSC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC trans rs3733585 0.699 rs28610447 chr4:9971517 T/C cg26043149 chr18:55253948 FECH -0.46 -7.06 -0.36 9.83e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg08213375 chr14:104286397 PPP1R13B 0.52 10.33 0.49 6.97e-22 Schizophrenia; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.69 0.54 1.04e-26 Prudent dietary pattern; LUSC trans rs11098499 0.863 rs11947234 chr4:120474859 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs6500395 0.651 rs28432694 chr16:48666310 A/T cg04672837 chr16:48644449 N4BP1 0.45 6.48 0.33 3.38e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.98 -12.98 -0.58 1.87e-31 Chronic sinus infection; LUSC cis rs694739 0.628 rs10897487 chr11:64140704 C/T cg23796481 chr11:64053134 BAD;GPR137 0.53 8.16 0.41 7e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.88 0.48 2.27e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs3099143 1.000 rs2046415 chr15:77085253 A/G cg21673338 chr15:77095150 SCAPER -0.73 -7.47 -0.38 6.9e-13 Recalcitrant atopic dermatitis; LUSC trans rs62103177 0.525 rs4799117 chr18:77756604 G/A cg14227996 chr4:17616232 MED28 -0.58 -6.47 -0.33 3.42e-10 Opioid sensitivity; LUSC trans rs9929218 0.954 rs10163398 chr16:68823124 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.09 -0.52 1.52e-24 Colorectal cancer; LUSC cis rs8077889 0.672 rs1230400 chr17:41845451 G/A cg26893861 chr17:41843967 DUSP3 -1.12 -24.64 -0.8 4.12e-77 Triglycerides; LUSC cis rs3540 0.597 rs11639150 chr15:91042071 C/G cg10434728 chr15:90938212 IQGAP1 -0.45 -9.14 -0.45 6.2e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12545109 0.765 rs2610047 chr8:57412106 T/C cg09654669 chr8:57350985 NA -0.58 -7.84 -0.39 5.98e-14 Obesity-related traits; LUSC cis rs1775715 0.870 rs1251400 chr10:32235145 A/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.46 0.33 3.65e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4786125 0.636 rs9932626 chr16:6917014 C/G cg03623568 chr16:6915990 A2BP1 -0.41 -6.97 -0.36 1.73e-11 Heart rate variability traits (SDNN); LUSC cis rs7186908 0.711 rs9923344 chr16:72190653 T/C cg01557791 chr16:72042693 DHODH -0.46 -5.85 -0.3 1.17e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7267979 1.000 rs6050602 chr20:25401203 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12493885 0.505 rs357489 chr3:153884517 A/T cg10247383 chr3:153839028 SGEF -0.57 -7.52 -0.38 5.04e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs977987 0.843 rs4888427 chr16:75478447 A/G cg04384234 chr16:75411784 CFDP1 -0.44 -7.36 -0.37 1.41e-12 Dupuytren's disease; LUSC cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.68 0.34 9.72e-11 Schizophrenia; LUSC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg13319975 chr6:146136371 FBXO30 -0.47 -7.22 -0.37 3.57e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4423214 1.000 rs4423214 chr11:71173254 C/T cg05163923 chr11:71159392 DHCR7 0.74 11.0 0.52 3.15e-24 Vitamin D levels; LUSC trans rs4811340 0.600 rs6068248 chr20:51179089 C/T cg15736553 chr3:11610338 VGLL4 -0.33 -5.95 -0.31 6.7e-9 Thyroid peroxidase antibody positivity; LUSC cis rs7582180 0.629 rs11694642 chr2:100957813 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.77 0.3 1.81e-8 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC cis rs7927592 0.956 rs11228277 chr11:68308324 G/A cg01657329 chr11:68192670 LRP5 -0.44 -6.55 -0.34 2.19e-10 Total body bone mineral density; LUSC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.24e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs57221529 0.766 rs12518859 chr5:587432 C/T cg11887960 chr12:57824829 NA 0.56 6.84 0.35 3.75e-11 Lung disease severity in cystic fibrosis; LUSC cis rs1018836 0.608 rs6986165 chr8:91477062 C/G cg16814680 chr8:91681699 NA -0.56 -8.26 -0.41 3.37e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs988712 0.705 rs4074134 chr11:27647285 C/T cg10635145 chr11:27742435 BDNF -0.45 -5.89 -0.31 9.21e-9 Obesity; LUSC cis rs11112613 0.713 rs12321309 chr12:105943263 T/G cg03607813 chr12:105948248 NA 0.8 11.29 0.53 3.04e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.31 0.49 8.3e-22 Bladder cancer; LUSC cis rs17539620 0.702 rs6937366 chr6:154878832 T/A cg20019720 chr6:154832845 CNKSR3 0.47 6.94 0.35 2.07e-11 Lipoprotein (a) levels; LUSC trans rs72674100 1.000 rs112113294 chr4:97967853 G/T cg16405019 chr1:18959625 PAX7 -0.61 -6.0 -0.31 5.27e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs78572108 0.858 rs72613885 chr2:42265011 A/G cg00607755 chr2:42274082 PKDCC 0.37 6.56 0.34 2.03e-10 Total body bone mineral density; LUSC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg24549020 chr5:56110836 MAP3K1 0.49 5.96 0.31 6.45e-9 Initial pursuit acceleration; LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13012494 chr21:47604986 C21orf56 -0.46 -7.16 -0.36 5.28e-12 Testicular germ cell tumor; LUSC cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs35146811 0.735 rs1727138 chr7:99815247 A/G cg19116668 chr7:99932089 PMS2L1 0.33 5.72 0.3 2.34e-8 Coronary artery disease; LUSC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg11764359 chr7:65958608 NA -0.82 -13.78 -0.6 1.69e-34 Aortic root size; LUSC cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg20503657 chr10:835505 NA -0.49 -6.86 -0.35 3.31e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs62400317 0.826 rs11968637 chr6:45348633 G/A cg20913747 chr6:44695427 NA -0.47 -7.76 -0.39 1.07e-13 Total body bone mineral density; LUSC cis rs955333 0.685 rs1022404 chr6:154899702 G/T cg20019720 chr6:154832845 CNKSR3 -0.43 -6.09 -0.32 3.07e-9 Diabetic kidney disease; LUSC cis rs2012796 0.956 rs7147254 chr14:81820503 G/A cg02996355 chr14:81879375 NA 0.49 7.1 0.36 7.5e-12 Night sleep phenotypes; LUSC cis rs8135665 0.625 rs34385006 chr22:38450291 C/T cg13116946 chr22:38479732 SLC16A8 0.4 5.91 0.31 8.46e-9 Advanced age-related macular degeneration;Age-related macular degeneration; LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg16405210 chr4:1374714 KIAA1530 -0.53 -7.95 -0.4 2.95e-14 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06825153 chr1:90287453 LRRC8D -0.42 -6.85 -0.35 3.52e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg23172400 chr8:95962367 TP53INP1 -0.35 -6.59 -0.34 1.74e-10 Type 2 diabetes; LUSC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg14440974 chr22:39074834 NA -0.34 -5.75 -0.3 1.97e-8 Menopause (age at onset); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg03904586 chr7:559740 PDGFA 0.39 6.38 0.33 5.85e-10 Mosquito bite size; LUSC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg02353165 chr6:42928485 GNMT -0.44 -7.09 -0.36 8.02e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -8.47 -0.42 8.19e-16 Lymphocyte counts; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg07806771 chr7:64541737 NA -0.44 -6.37 -0.33 6.24e-10 Calcium levels; LUSC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.92 0.44 3.19e-17 Prudent dietary pattern; LUSC trans rs7786808 0.544 rs6971888 chr7:158193835 G/A cg02030672 chr11:45687055 CHST1 -0.44 -6.81 -0.35 4.65e-11 Obesity-related traits; LUSC cis rs4363385 0.755 rs516198 chr1:153026196 T/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.41 -0.38 1.07e-12 Inflammatory skin disease; LUSC trans rs1864729 1.000 rs2439700 chr8:98277168 G/A cg08679828 chr8:102218111 ZNF706 -0.87 -7.83 -0.39 6.43e-14 Estradiol plasma levels (breast cancer); LUSC cis rs983392 0.651 rs718376 chr11:60002935 C/T cg20284999 chr11:59952153 MS4A6A -0.35 -5.74 -0.3 2.18e-8 Alzheimer's disease (late onset); LUSC cis rs9303401 0.632 rs7502541 chr17:57241019 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.47 6.8 0.35 4.87e-11 Cognitive test performance; LUSC cis rs16912285 0.748 rs7104694 chr11:24280281 A/C ch.11.24196551F chr11:24239977 NA 0.85 9.04 0.44 1.34e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7615952 0.546 rs16836896 chr3:125311262 A/T cg05084668 chr3:125655381 ALG1L -0.44 -5.82 -0.3 1.35e-8 Blood pressure (smoking interaction); LUSC trans rs9860340 0.730 rs4859089 chr3:87648553 C/G cg03644585 chr7:884825 UNC84A -0.42 -6.03 -0.31 4.34e-9 Electroencephalographic traits in alcoholism; LUSC trans rs4942242 0.663 rs9525816 chr13:44223898 A/G cg19169023 chr15:41853346 TYRO3 -0.57 -8.6 -0.43 3.05e-16 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9300255 0.506 rs11057251 chr12:123791227 A/G cg05973401 chr12:123451056 ABCB9 -0.52 -7.65 -0.39 2.18e-13 Neutrophil percentage of white cells; LUSC cis rs1790761 0.692 rs1269981 chr11:67334959 G/A cg23188684 chr11:67383651 NA 0.34 6.02 0.31 4.67e-9 Mean corpuscular volume; LUSC cis rs9811920 0.809 rs4928153 chr3:99808445 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.34 5.77 0.3 1.78e-8 Axial length; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23587005 chr12:9600941 DDX12 0.36 5.96 0.31 6.56e-9 Triglycerides; LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.17 0.37 4.7e-12 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09326880 chr3:43147587 C3orf39 -0.43 -6.59 -0.34 1.7e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.11e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7605827 0.930 rs10929366 chr2:15531754 C/T cg19274914 chr2:15703543 NA 0.48 9.34 0.46 1.39e-18 Educational attainment (years of education); LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg23034840 chr1:205782522 SLC41A1 0.62 8.8 0.43 7.43e-17 Menarche (age at onset); LUSC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs920590 0.643 rs3855754 chr8:19659499 C/G cg03894339 chr8:19674705 INTS10 0.41 5.85 0.3 1.19e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg18904891 chr8:8559673 CLDN23 0.6 8.08 0.4 1.16e-14 Obesity-related traits; LUSC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg15445000 chr17:37608096 MED1 0.38 6.61 0.34 1.53e-10 Glomerular filtration rate (creatinine); LUSC cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.82 -0.39 6.88e-14 Chronic sinus infection; LUSC cis rs12681288 0.823 rs2701909 chr8:1003057 A/G cg04851639 chr8:1020857 NA -0.37 -7.78 -0.39 8.96e-14 Schizophrenia; LUSC cis rs860295 0.812 rs12081192 chr1:155738044 A/G cg08949192 chr1:155289623 RUSC1;FDPS -0.34 -5.76 -0.3 1.93e-8 Body mass index; LUSC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg20090143 chr19:45452003 APOC2 0.47 8.77 0.43 9.29e-17 Blood protein levels; LUSC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg06112835 chr11:68658793 MRPL21 0.48 7.36 0.37 1.45e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg22166914 chr1:53195759 ZYG11B -0.62 -10.46 -0.5 2.37e-22 Monocyte count; LUSC trans rs9831754 1.000 rs9822043 chr3:78352113 T/C cg06695833 chr19:18220682 MAST3 0.48 6.08 0.32 3.2e-9 Calcium levels; LUSC cis rs9479482 1.000 rs11155697 chr6:150357423 C/T cg25797454 chr6:150327115 RAET1K 0.35 7.98 0.4 2.34e-14 Alopecia areata; LUSC cis rs6714710 0.580 rs35564270 chr2:98602165 A/G cg26665480 chr2:98280029 ACTR1B 0.59 8.41 0.42 1.24e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg15073853 chr19:18549131 ISYNA1 -0.32 -5.79 -0.3 1.64e-8 Breast cancer; LUSC cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg00071950 chr4:10020882 SLC2A9 0.58 9.96 0.48 1.27e-20 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7940866 0.838 rs10736592 chr11:130800572 C/T cg12179176 chr11:130786555 SNX19 0.62 9.59 0.46 2.06e-19 Schizophrenia; LUSC cis rs72781680 1.000 rs12616250 chr2:24211550 T/C cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC trans rs1728785 1.000 rs1728780 chr16:68567642 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs4319547 0.695 rs4758662 chr12:122924778 G/A cg23029597 chr12:123009494 RSRC2 -0.74 -9.23 -0.45 3.1e-18 Body mass index; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg21733973 chr7:65235735 NA 0.44 6.21 0.32 1.58e-9 Calcium levels; LUSC cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC cis rs11030122 0.702 rs10835406 chr11:3992954 G/T cg08557956 chr11:4115526 RRM1 0.45 5.67 0.3 3.13e-8 Mean platelet volume;Platelet distribution width; LUSC trans rs9329221 0.537 rs1484640 chr8:9983243 G/T cg15556689 chr8:8085844 FLJ10661 0.54 8.12 0.41 9.32e-15 Neuroticism; LUSC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg06550200 chr5:1325588 CLPTM1L -0.67 -11.71 -0.54 8.76e-27 Lung cancer; LUSC cis rs7618501 1.000 rs7634902 chr3:49762662 G/T cg12257692 chr3:49977190 RBM6 -0.21 -5.72 -0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg16339924 chr4:17578868 LAP3 0.54 8.11 0.41 1e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10203711 0.966 rs4293520 chr2:239567184 A/C cg14580085 chr2:239553406 NA 0.41 6.99 0.36 1.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg03433033 chr1:76189801 ACADM -0.71 -9.89 -0.48 2.06e-20 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.44 0.53 8.25e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg16447950 chr5:562315 NA -0.52 -6.88 -0.35 3e-11 Obesity-related traits; LUSC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg22535103 chr8:58192502 C8orf71 -0.58 -7.03 -0.36 1.2e-11 Developmental language disorder (linguistic errors); LUSC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg07936489 chr17:37558343 FBXL20 0.72 10.11 0.48 3.74e-21 Glomerular filtration rate (creatinine); LUSC trans rs7726558 0.642 rs3797371 chr5:118869764 C/T cg14402224 chr7:50570049 DDC 0.48 6.45 0.33 3.9e-10 QT interval (sulfonylurea treatment interaction); LUSC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg04944784 chr2:26401820 FAM59B -0.68 -9.69 -0.47 9.62e-20 Gut microbiome composition (summer); LUSC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg00814883 chr7:100076585 TSC22D4 -0.73 -9.7 -0.47 9.39e-20 Platelet count; LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg03433033 chr1:76189801 ACADM 0.82 14.21 0.61 3.48e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10779751 0.734 rs7533211 chr1:11132965 G/C cg04508216 chr1:11107452 MASP2 0.31 5.72 0.3 2.4e-8 Body mass index; LUSC cis rs9925964 0.804 rs4889606 chr16:31011183 C/T cg02466173 chr16:30829666 NA -0.32 -5.74 -0.3 2.08e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12692738 0.526 rs355852 chr2:165626304 C/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg11345693 chr17:79170810 AZI1 -0.34 -6.93 -0.35 2.22e-11 Frontotemporal dementia; LUSC cis rs870825 0.616 rs1401360 chr4:185643571 T/C cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs11112613 0.609 rs4388999 chr12:106047758 G/T cg03607813 chr12:105948248 NA 0.62 7.7 0.39 1.51e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs9650315 0.929 rs66592895 chr8:57167361 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs6964587 1.000 rs11982047 chr7:91705274 G/A cg22709100 chr7:91322751 NA 0.42 6.19 0.32 1.75e-9 Breast cancer; LUSC cis rs3087591 1.000 rs2012988 chr17:29547296 T/C cg24425628 chr17:29625626 OMG;NF1 0.56 8.25 0.41 3.59e-15 Hip circumference; LUSC cis rs8114671 0.869 rs1544047 chr20:33670753 T/C cg24642439 chr20:33292090 TP53INP2 -0.41 -5.89 -0.31 9.23e-9 Height; LUSC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg06238570 chr21:40685208 BRWD1 -0.57 -8.95 -0.44 2.49e-17 Menarche (age at onset); LUSC cis rs12545109 0.800 rs1561224 chr8:57419922 T/C cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC cis rs9467711 0.651 rs35402046 chr6:26099472 G/A cg08501292 chr6:25962987 TRIM38 0.64 5.85 0.3 1.17e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg23359048 chr12:2921757 ITFG2 0.53 6.44 0.33 4.28e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs920590 0.758 rs35280191 chr8:19665214 A/C cg03894339 chr8:19674705 INTS10 0.52 6.96 0.36 1.84e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs72781680 1.000 rs963725 chr2:24148231 T/C cg20701182 chr2:24300061 SF3B14 0.77 7.73 0.39 1.25e-13 Lymphocyte counts; LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs9560113 1.000 rs9555811 chr13:112181532 A/C cg14154082 chr13:112174009 NA 0.38 7.88 0.4 4.53e-14 Menarche (age at onset); LUSC cis rs12188164 0.543 rs890972 chr5:462465 C/A cg00049323 chr5:472564 LOC25845 0.49 7.75 0.39 1.08e-13 Cystic fibrosis severity; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11064558 chr21:43430383 ZNF295 -0.45 -5.96 -0.31 6.52e-9 Hepatitis; LUSC cis rs11247915 0.600 rs3795686 chr1:26582091 G/A cg04990556 chr1:26633338 UBXN11 -0.5 -6.91 -0.35 2.4e-11 Obesity-related traits; LUSC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg18876405 chr7:65276391 NA 0.76 13.54 0.6 1.38e-33 Aortic root size; LUSC cis rs4820318 1 rs4820318 chr22:38570313 G/A cg17652424 chr22:38574118 PLA2G6 -0.28 -5.83 -0.3 1.34e-8 Breast cancer; LUSC trans rs1728785 0.901 rs1170444 chr16:68573287 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.51 0.38 5.28e-13 Ulcerative colitis; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg13307023 chr16:1359278 UBE2I 0.45 6.85 0.35 3.54e-11 Metabolite levels (Pyroglutamine); LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -1.01 -14.26 -0.62 2.21e-36 Platelet count; LUSC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg06212747 chr3:49208901 KLHDC8B 0.45 6.09 0.32 3.07e-9 Parkinson's disease; LUSC cis rs1448094 0.872 rs10863146 chr12:86408326 C/G cg00310523 chr12:86230176 RASSF9 0.36 6.44 0.33 4.07e-10 Major depressive disorder; LUSC cis rs239198 0.568 rs979122 chr6:101332215 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.3 -0.33 9.29e-10 Menarche (age at onset); LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg25767906 chr1:53392781 SCP2 0.48 8.69 0.43 1.67e-16 Monocyte count; LUSC cis rs59698941 0.943 rs12515752 chr5:132312960 C/G cg02081065 chr5:132209139 LEAP2 -0.64 -6.4 -0.33 5.16e-10 Apolipoprotein A-IV levels; LUSC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg01802117 chr1:53393560 SCP2 0.38 6.03 0.31 4.32e-9 Monocyte count; LUSC cis rs6121246 0.909 rs1994249 chr20:30287593 C/T cg18721089 chr20:30220636 NA -0.35 -5.98 -0.31 5.83e-9 Mean corpuscular hemoglobin; LUSC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11890956 chr21:40555474 PSMG1 1.05 21.16 0.76 1.22e-63 Cognitive function; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01881136 chr16:89438758 ANKRD11 -0.72 -6.27 -0.32 1.13e-9 Cognitive performance; LUSC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg21724239 chr8:58056113 NA 0.59 6.75 0.35 6.42e-11 Developmental language disorder (linguistic errors); LUSC cis rs2292884 0.505 rs11889660 chr2:238438395 C/T cg16989719 chr2:238392110 NA -0.49 -6.32 -0.33 8.19e-10 Prostate cancer; LUSC trans rs12458462 0.851 rs2169249 chr18:77489649 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.33 -0.33 7.73e-10 Monocyte count; LUSC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg13647721 chr17:30228624 UTP6 0.59 6.1 0.32 2.98e-9 Hip circumference adjusted for BMI; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10964577 chr17:15160725 PMP22 0.42 6.2 0.32 1.67e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs877282 0.898 rs12359731 chr10:759497 A/G cg17470449 chr10:769945 NA 0.5 7.66 0.39 2.06e-13 Uric acid levels; LUSC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Parkinson's disease; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg07362569 chr17:61921086 SMARCD2 0.37 7.3 0.37 2.14e-12 Prudent dietary pattern; LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg18099408 chr3:52552593 STAB1 -0.43 -7.32 -0.37 1.87e-12 Bipolar disorder; LUSC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg11812906 chr14:75593930 NEK9 -0.65 -10.63 -0.5 6.39e-23 Height; LUSC cis rs9925964 0.748 rs4889603 chr16:30982225 C/T cg02466173 chr16:30829666 NA -0.38 -7.23 -0.37 3.37e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg25427524 chr10:38739819 LOC399744 -0.72 -13.51 -0.59 1.8e-33 Extrinsic epigenetic age acceleration; LUSC cis rs16854884 0.609 rs9872126 chr3:143683851 G/A cg01302019 chr3:143689584 C3orf58 -0.43 -7.52 -0.38 5.22e-13 Economic and political preferences (feminism/equality); LUSC cis rs7789940 1.000 rs11765693 chr7:75985373 A/G cg10167463 chr7:75959203 YWHAG -0.66 -10.07 -0.48 5.33e-21 Multiple sclerosis; LUSC cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.43e-28 Intelligence (multi-trait analysis); LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18404041 chr3:52824283 ITIH1 -0.5 -9.39 -0.46 9.91e-19 Bipolar disorder; LUSC cis rs4072705 1.000 rs13283284 chr9:127516177 T/C cg13476313 chr9:127244764 NR5A1 0.29 5.65 0.3 3.52e-8 Menarche (age at onset); LUSC trans rs1814175 0.791 rs10769593 chr11:49616217 T/C cg03929089 chr4:120376271 NA -1.03 -18.64 -0.71 1.17e-53 Height; LUSC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.12 0.36 6.77e-12 Hip circumference adjusted for BMI; LUSC cis rs1371867 0.875 rs1788176 chr8:101332112 A/G cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs9420 0.961 rs11602109 chr11:57435296 G/A cg23127183 chr11:57508653 C11orf31 -0.59 -9.09 -0.45 8.86e-18 Schizophrenia; LUSC cis rs7666738 0.579 rs7672718 chr4:98645122 A/G cg05340658 chr4:99064831 C4orf37 0.57 8.61 0.43 2.84e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs4664308 0.935 rs6744567 chr2:160933781 C/G cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg03806693 chr22:41940476 POLR3H -1.02 -14.5 -0.62 2.59e-37 Vitiligo; LUSC cis rs7605827 0.930 rs59135666 chr2:15592448 G/A cg19274914 chr2:15703543 NA 0.48 9.21 0.45 3.77e-18 Educational attainment (years of education); LUSC cis rs2387326 0.717 rs10829340 chr10:129943941 G/T cg16087940 chr10:129947807 NA -0.39 -6.0 -0.31 5.27e-9 Select biomarker traits; LUSC cis rs6665290 0.904 rs2297415 chr1:227172903 G/A cg10327440 chr1:227177885 CDC42BPA -1.23 -39.3 -0.91 2.68e-127 Myeloid white cell count; LUSC cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs9905704 0.647 rs6503892 chr17:57067086 G/A cg12560992 chr17:57184187 TRIM37 0.62 9.96 0.48 1.29e-20 Testicular germ cell tumor; LUSC cis rs7572733 0.534 rs700682 chr2:198712310 C/A cg00792783 chr2:198669748 PLCL1 0.43 5.87 0.31 1.04e-8 Dermatomyositis; LUSC cis rs9527 0.590 rs12246739 chr10:104787019 A/C cg04362960 chr10:104952993 NT5C2 -0.6 -9.35 -0.46 1.33e-18 Arsenic metabolism; LUSC cis rs2273669 0.667 rs12195848 chr6:109279105 A/C cg05315195 chr6:109294784 ARMC2 -0.6 -6.6 -0.34 1.66e-10 Prostate cancer; LUSC cis rs7903847 0.642 rs6584127 chr10:99142948 A/C cg08345082 chr10:99160200 RRP12 -0.36 -7.31 -0.37 2.02e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs4595586 0.545 rs3911798 chr12:39389901 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.13 0.36 6.31e-12 Morning vs. evening chronotype; LUSC cis rs13266463 0.830 rs7014552 chr8:143410423 A/G cg16886403 chr8:143471632 TSNARE1 0.61 9.07 0.44 1.02e-17 Schizophrenia; LUSC cis rs9399401 0.961 rs7741741 chr6:142655801 T/A cg03128060 chr6:142623767 GPR126 0.31 5.68 0.3 3e-8 Chronic obstructive pulmonary disease; LUSC cis rs636291 0.517 rs12565133 chr1:10544988 A/C cg17425144 chr1:10567563 PEX14 -0.58 -11.8 -0.54 4.15e-27 Prostate cancer; LUSC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg07701084 chr6:150067640 NUP43 0.57 8.74 0.43 1.14e-16 Lung cancer; LUSC cis rs7605827 0.897 rs11684844 chr2:15640552 T/A cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.74e-17 Educational attainment (years of education); LUSC cis rs3862030 0.810 rs5870 chr10:104239100 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.6 -9.47 -0.46 5.4e-19 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg12560992 chr17:57184187 TRIM37 0.41 6.22 0.32 1.48e-9 Cognitive test performance; LUSC cis rs908922 0.676 rs6587681 chr1:152512135 C/T cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg10729496 chr3:10149963 C3orf24 0.53 7.21 0.37 3.79e-12 Alzheimer's disease; LUSC cis rs7560272 0.538 rs4241257 chr2:73938607 T/C cg20560298 chr2:73613845 ALMS1 0.42 6.47 0.33 3.44e-10 Schizophrenia; LUSC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03264133 chr6:25882463 NA -0.62 -10.56 -0.5 1.13e-22 Blood metabolite levels; LUSC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg05872129 chr22:39784769 NA -0.58 -10.59 -0.5 8.65e-23 Intelligence (multi-trait analysis); LUSC cis rs6961069 0.585 rs6968407 chr7:80238117 C/A cg04458919 chr7:80252533 CD36 -0.4 -7.07 -0.36 9.39e-12 Platelet count; LUSC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.07 -0.36 8.99e-12 Alzheimer's disease (late onset); LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.54 -7.6 -0.38 3.02e-13 Alzheimer's disease (late onset); LUSC cis rs7246657 0.653 rs10401525 chr19:37658979 C/G cg23950597 chr19:37808831 NA -0.58 -5.84 -0.3 1.24e-8 Coronary artery calcification; LUSC cis rs6977660 0.943 rs9638765 chr7:19840616 G/A cg07541023 chr7:19748670 TWISTNB 0.53 6.13 0.32 2.51e-9 Thyroid stimulating hormone; LUSC trans rs6952808 1.000 rs10260585 chr7:1889521 G/A cg24247370 chr13:99142703 STK24 -0.33 -6.09 -0.32 3.09e-9 Bipolar disorder and schizophrenia; LUSC cis rs7267979 0.866 rs437635 chr20:25456888 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.83 0.75 2.5e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4132509 0.744 rs320305 chr1:243859909 G/T cg21452805 chr1:244014465 NA 0.64 6.92 0.35 2.31e-11 RR interval (heart rate); LUSC cis rs1153858 0.668 rs63603561 chr15:45593323 T/A cg14582100 chr15:45693742 SPATA5L1 -0.54 -9.13 -0.45 6.62e-18 Homoarginine levels; LUSC cis rs72781680 0.821 rs11894756 chr2:24170214 A/G cg08917208 chr2:24149416 ATAD2B -0.64 -7.01 -0.36 1.34e-11 Lymphocyte counts; LUSC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg07395648 chr5:131743802 NA -0.46 -7.37 -0.37 1.31e-12 Breast cancer;Mosquito bite size; LUSC cis rs2806561 0.765 rs682766 chr1:23516397 C/G cg19743168 chr1:23544995 NA 0.4 7.89 0.4 4.25e-14 Height; LUSC cis rs35828350 1 rs35828350 chr15:85355841 G/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.49 0.33 3.11e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs735396 0.731 rs1182933 chr12:121454622 C/T cg25281562 chr12:121454272 C12orf43 0.45 5.84 0.3 1.22e-8 N-glycan levels; LUSC cis rs7119 0.651 rs12904208 chr15:77845911 C/T cg27398640 chr15:77910606 LINGO1 -0.32 -6.92 -0.35 2.32e-11 Type 2 diabetes; LUSC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg27266027 chr21:40555129 PSMG1 -0.39 -5.72 -0.3 2.43e-8 Cognitive function; LUSC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11644478 chr21:40555479 PSMG1 0.94 19.04 0.72 2.9e-55 Cognitive function; LUSC cis rs7202877 0.706 rs2059257 chr16:75396376 G/A cg04384234 chr16:75411784 CFDP1 -0.66 -9.47 -0.46 5.22e-19 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.43 0.5 3.19e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs35146811 0.660 rs3779046 chr7:99779243 A/G cg13334819 chr7:99746414 C7orf59 -0.5 -6.67 -0.34 1.05e-10 Coronary artery disease; LUSC cis rs12579753 0.917 rs10129029 chr12:82180324 G/A cg07988820 chr12:82153109 PPFIA2 -0.4 -5.66 -0.3 3.31e-8 Resting heart rate; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15556090 chr7:149195153 ZNF746 -0.42 -6.07 -0.32 3.52e-9 Electrocardiographic conduction measures; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08830225 chr13:34116653 NA -0.44 -6.62 -0.34 1.4e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.02 -0.31 4.47e-9 Huntington's disease progression; LUSC cis rs3126085 0.877 rs3126045 chr1:152256794 A/G cg26876637 chr1:152193138 HRNR 0.45 6.08 0.32 3.31e-9 Atopic dermatitis; LUSC cis rs2652834 1.000 rs2729833 chr15:63397044 G/A cg05507819 chr15:63340323 TPM1 0.66 8.01 0.4 1.95e-14 HDL cholesterol; LUSC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg22800045 chr5:56110881 MAP3K1 0.44 6.2 0.32 1.69e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg03975922 chr5:140080575 ZMAT2 0.31 5.65 0.3 3.46e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08958952 chr8:142262761 NA 0.48 6.15 0.32 2.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.512 rs6060938 chr20:30363645 T/C cg13852791 chr20:30311386 BCL2L1 0.95 14.9 0.63 7.51e-39 Mean corpuscular hemoglobin; LUSC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11890956 chr21:40555474 PSMG1 1.03 20.73 0.75 5.92e-62 Cognitive function; LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.568 rs1727300 chr12:123664205 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.48 0.33 3.34e-10 Neutrophil percentage of white cells; LUSC cis rs834603 0.575 rs1799376 chr7:47479583 C/T cg09696706 chr7:47479511 TNS3 0.35 6.33 0.33 8.01e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg25208724 chr1:156163844 SLC25A44 1.08 25.53 0.81 1.77e-80 Testicular germ cell tumor; LUSC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg20243544 chr17:37824526 PNMT 0.39 5.85 0.3 1.19e-8 Self-reported allergy; LUSC cis rs8072100 0.967 rs9894905 chr17:45485982 C/T cg08085267 chr17:45401833 C17orf57 -0.63 -10.82 -0.51 1.39e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg12292205 chr6:26970375 C6orf41 -0.58 -7.16 -0.36 5.14e-12 Intelligence (multi-trait analysis); LUSC cis rs427394 0.664 rs274697 chr5:6731477 A/C cg10857441 chr5:6722123 POLS -0.44 -8.67 -0.43 1.88e-16 Menopause (age at onset); LUSC cis rs12410462 0.579 rs116423559 chr1:227575014 A/G cg23173402 chr1:227635558 NA 0.57 6.23 0.32 1.38e-9 Major depressive disorder; LUSC cis rs7264396 0.747 rs2425112 chr20:34319775 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.47 -0.46 5.35e-19 Total cholesterol levels; LUSC cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg18404041 chr3:52824283 ITIH1 0.42 7.32 0.37 1.83e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg01206211 chr2:36825736 FEZ2 -0.52 -11.96 -0.55 1.12e-27 Height; LUSC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg22823121 chr1:150693482 HORMAD1 0.47 7.02 0.36 1.28e-11 Melanoma; LUSC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg12560992 chr17:57184187 TRIM37 0.83 15.25 0.64 3.25e-40 Intelligence (multi-trait analysis); LUSC cis rs2115536 0.720 rs12916091 chr15:80222572 T/G cg00225070 chr15:80189496 MTHFS 0.6 8.88 0.44 4.31e-17 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7312933 0.618 rs6582390 chr12:42634586 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.85 0.35 3.51e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg26441486 chr22:50317300 CRELD2 0.53 8.07 0.4 1.27e-14 Schizophrenia; LUSC trans rs6089829 0.962 rs3899032 chr20:61658542 G/A cg23505145 chr19:12996616 KLF1 0.64 10.29 0.49 9.57e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg24829409 chr8:58192753 C8orf71 -0.59 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg19592336 chr6:28129416 ZNF389 0.49 6.58 0.34 1.87e-10 Depression; LUSC cis rs4595586 0.545 rs1349257 chr12:39397139 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.22 0.37 3.52e-12 Morning vs. evening chronotype; LUSC trans rs7937682 0.883 rs1789351 chr11:111456436 T/A cg18187862 chr3:45730750 SACM1L 0.53 6.9 0.35 2.6e-11 Primary sclerosing cholangitis; LUSC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg00271210 chr6:167070053 RPS6KA2 -0.27 -5.71 -0.3 2.44e-8 Crohn's disease; LUSC cis rs950169 0.922 rs67804993 chr15:85104030 T/G cg17507749 chr15:85114479 UBE2QP1 0.72 9.42 0.46 7.56e-19 Schizophrenia; LUSC cis rs425277 1.000 rs262657 chr1:2088577 G/A cg03732007 chr1:2071316 PRKCZ 0.45 7.16 0.36 5.03e-12 Height; LUSC trans rs1814175 0.817 rs1621090 chr11:49895868 C/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.92 -0.81 3.6e-78 Height; LUSC cis rs4343996 0.967 rs4295560 chr7:3356072 G/A cg21248987 chr7:3385318 SDK1 -0.36 -6.15 -0.32 2.16e-9 Motion sickness; LUSC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg23711669 chr6:146136114 FBXO30 0.78 12.55 0.57 7.04e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs9527 0.615 rs4917991 chr10:104783833 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.83 0.47 3.35e-20 Arsenic metabolism; LUSC cis rs1401999 0.690 rs3805112 chr3:183645662 C/T cg05044414 chr3:183734942 ABCC5 0.2 6.78 0.35 5.41e-11 Anterior chamber depth; LUSC cis rs9916302 0.706 rs801418 chr17:37457982 G/C cg07936489 chr17:37558343 FBXL20 0.78 9.96 0.48 1.27e-20 Glomerular filtration rate (creatinine); LUSC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg20243544 chr17:37824526 PNMT 0.48 6.88 0.35 2.89e-11 Asthma; LUSC cis rs17030434 0.906 rs57446135 chr4:154679331 A/G cg14289246 chr4:154710475 SFRP2 -0.49 -6.49 -0.33 3.12e-10 Electrocardiographic conduction measures; LUSC cis rs59918340 0.764 rs4961256 chr8:142229946 G/A cg23750338 chr8:142222470 SLC45A4 0.58 11.15 0.52 9.23e-25 Immature fraction of reticulocytes; LUSC cis rs9747201 0.962 rs62078313 chr17:80116708 A/C cg17462356 chr17:80056334 FASN 0.45 6.05 0.31 3.94e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9359856 0.564 rs72915933 chr6:90441464 C/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.59 -0.43 3.45e-16 Bipolar disorder; LUSC cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs6500602 0.727 rs4786510 chr16:4571247 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs2086824 0.702 rs3114896 chr16:89393562 C/T cg00750074 chr16:89608354 SPG7 0.42 7.18 0.37 4.61e-12 Multiple myeloma (IgH translocation); LUSC trans rs11098499 0.542 rs10440343 chr4:120309787 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC trans rs3857536 0.674 rs9345798 chr6:66951331 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -5.99 -0.31 5.34e-9 Blood trace element (Cu levels); LUSC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.53 -0.34 2.42e-10 Bipolar disorder and schizophrenia; LUSC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg03806693 chr22:41940476 POLR3H -0.92 -13.68 -0.6 4.06e-34 Vitiligo; LUSC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg22857025 chr5:266934 NA -1.15 -16.9 -0.68 9.53e-47 Breast cancer; LUSC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg08132940 chr7:1081526 C7orf50 -0.46 -6.14 -0.32 2.3e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.79 0.39 8.71e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs77633900 0.892 rs874223 chr15:76631571 T/C cg21673338 chr15:77095150 SCAPER 0.62 5.74 0.3 2.12e-8 Non-glioblastoma glioma;Glioma; LUSC cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg07061783 chr6:25882402 NA -0.37 -5.87 -0.31 1.07e-8 Blood metabolite levels; LUSC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg04998671 chr14:104000505 TRMT61A -0.42 -5.94 -0.31 7.19e-9 Reticulocyte count; LUSC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg04362960 chr10:104952993 NT5C2 0.57 8.97 0.44 2.18e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.64 -0.34 1.27e-10 Bipolar disorder and schizophrenia; LUSC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg14440974 chr22:39074834 NA 0.34 5.77 0.3 1.85e-8 Menopause (age at onset); LUSC cis rs3820928 0.874 rs10167086 chr2:227792729 A/T cg11843606 chr2:227700838 RHBDD1 0.5 7.21 0.37 3.75e-12 Pulmonary function; LUSC cis rs7954584 0.531 rs6486781 chr12:122318985 A/C cg22618164 chr12:122356400 WDR66 0.57 8.09 0.4 1.1e-14 Mean corpuscular volume; LUSC cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.63 -0.39 2.42e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08109568 chr15:31115862 NA -0.59 -8.22 -0.41 4.55e-15 Huntington's disease progression; LUSC cis rs7953249 0.618 rs7954331 chr12:121398657 G/T cg25281562 chr12:121454272 C12orf43 -0.43 -5.65 -0.3 3.48e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs41271473 1.000 rs4993975 chr1:228878669 A/C cg16512390 chr1:228756714 NA 0.5 6.04 0.31 4.05e-9 Chronic lymphocytic leukemia; LUSC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg01017244 chr2:74357527 NA 0.67 11.85 0.54 2.7e-27 Gestational age at birth (maternal effect); LUSC cis rs17685 0.712 rs7794454 chr7:75776010 A/G cg16489192 chr7:75678113 MDH2;STYXL1 0.53 8.16 0.41 7.08e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg08742575 chr21:47604166 C21orf56 0.48 7.38 0.37 1.3e-12 Testicular germ cell tumor; LUSC cis rs6542838 0.641 rs6704682 chr2:99499602 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.08 -0.32 3.32e-9 Fear of minor pain; LUSC cis rs6939532 0.761 rs3799378 chr6:26404374 C/T cg09904177 chr6:26538194 HMGN4 0.43 6.22 0.32 1.52e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg14829155 chr15:31115871 NA -0.72 -10.66 -0.5 5.02e-23 Huntington's disease progression; LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.47 0.38 7.12e-13 Bipolar disorder; LUSC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg15839431 chr19:19639596 YJEFN3 -0.63 -7.11 -0.36 7.15e-12 Bipolar disorder; LUSC cis rs7829975 0.591 rs12677543 chr8:8644274 G/C cg01851573 chr8:8652454 MFHAS1 -0.37 -6.35 -0.33 7.06e-10 Mood instability; LUSC trans rs6502050 0.835 rs7222057 chr17:80087647 C/A cg07393940 chr7:158741817 NA 0.37 6.68 0.34 1.02e-10 Life satisfaction; LUSC cis rs78707713 0.512 rs35793747 chr10:71182165 A/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.64 -0.47 1.42e-19 Venous thromboembolism; LUSC trans rs1005277 0.529 rs1780125 chr10:38531376 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.41 -0.46 8.46e-19 Extrinsic epigenetic age acceleration; LUSC cis rs4144743 1.000 rs2015049 chr17:45332231 G/A cg18085866 chr17:45331354 ITGB3 -0.75 -7.81 -0.39 7.38e-14 Body mass index; LUSC cis rs7605827 0.930 rs1015837 chr2:15665847 C/T cg19274914 chr2:15703543 NA 0.45 8.66 0.43 2.09e-16 Educational attainment (years of education); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03864326 chr16:67927170 PSKH1 0.38 5.98 0.31 5.61e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3812762 0.879 rs10769952 chr11:8776700 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.38 6.58 0.34 1.85e-10 Hypospadias; LUSC cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg16230307 chr14:35515116 FAM177A1 0.82 10.3 0.49 8.57e-22 Psoriasis; LUSC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg27165867 chr14:105738592 BRF1 -0.54 -7.88 -0.4 4.8e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs3126085 0.935 rs11204934 chr1:152176848 C/A cg26876637 chr1:152193138 HRNR -0.44 -6.12 -0.32 2.68e-9 Atopic dermatitis; LUSC cis rs2346177 0.605 rs7598712 chr2:46660452 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.63 -10.17 -0.49 2.37e-21 HDL cholesterol; LUSC cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg05283184 chr6:79620031 NA -0.56 -11.8 -0.54 4.4e-27 Intelligence (multi-trait analysis); LUSC cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg26647111 chr11:31128758 NA -0.41 -6.0 -0.31 5.27e-9 Bone mineral density (spine); LUSC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg18876405 chr7:65276391 NA -0.54 -8.68 -0.43 1.78e-16 Aortic root size; LUSC cis rs9473147 0.516 rs10948367 chr6:47585615 A/G cg12968598 chr6:47444699 CD2AP 0.52 7.94 0.4 3.05e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7727544 0.548 rs35696821 chr5:131508017 C/T cg14196790 chr5:131705035 SLC22A5 0.47 8.01 0.4 1.89e-14 Blood metabolite levels; LUSC cis rs10927875 0.929 rs4661674 chr1:16296039 A/G cg21385522 chr1:16154831 NA -0.76 -11.92 -0.55 1.6e-27 Dilated cardiomyopathy; LUSC cis rs6429082 0.811 rs291348 chr1:235667690 A/G cg26050004 chr1:235667680 B3GALNT2 0.82 14.19 0.61 4.36e-36 Adiposity; LUSC cis rs981844 0.712 rs1037652 chr4:154746565 C/T cg14289246 chr4:154710475 SFRP2 0.46 6.23 0.32 1.37e-9 Response to statins (LDL cholesterol change); LUSC cis rs12824058 0.831 rs11608407 chr12:130805869 G/A cg26677194 chr12:130822605 PIWIL1 0.56 8.41 0.42 1.21e-15 Menopause (age at onset); LUSC cis rs1728785 1.000 rs1728780 chr16:68567642 G/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC trans rs11098499 0.863 rs1383533 chr4:120434576 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.58 0.34 1.84e-10 Corneal astigmatism; LUSC cis rs11711311 1.000 rs1073040 chr3:113522123 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.65 0.34 1.22e-10 IgG glycosylation; LUSC cis rs2742417 0.603 rs2064062 chr3:45761115 G/C cg10512202 chr3:45649293 LIMD1 0.36 6.04 0.31 4.18e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg17158414 chr2:27665306 KRTCAP3 -0.34 -6.53 -0.34 2.46e-10 Total body bone mineral density; LUSC cis rs4665809 0.590 rs11126339 chr2:26253223 T/C cg22920501 chr2:26401640 FAM59B -0.63 -8.69 -0.43 1.61e-16 Gut microbiome composition (summer); LUSC cis rs8179 0.645 rs2282979 chr7:92264993 T/C cg15732164 chr7:92237376 CDK6 -0.4 -5.71 -0.3 2.44e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs4409675 0.576 rs3766396 chr1:28221554 C/T cg23691781 chr1:28212827 C1orf38 -0.31 -7.57 -0.38 3.7e-13 Corneal astigmatism; LUSC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg14552801 chr7:65878734 NA -0.41 -6.4 -0.33 5.13e-10 Aortic root size; LUSC cis rs9467773 1.000 rs6922824 chr6:26553815 C/G cg11502198 chr6:26597334 ABT1 -0.59 -9.25 -0.45 2.77e-18 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg19774624 chr17:42201019 HDAC5 -0.82 -13.9 -0.61 5.65e-35 Total body bone mineral density; LUSC cis rs59072704 0.843 rs12028532 chr1:244498605 T/C cg16908123 chr1:244486252 NA -0.34 -6.77 -0.35 5.93e-11 Monocyte count; LUSC cis rs951366 0.576 rs11240559 chr1:205709621 T/G cg11965913 chr1:205819406 PM20D1 -0.49 -6.74 -0.35 6.9e-11 Menarche (age at onset); LUSC cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg08807101 chr21:30365312 RNF160 0.73 13.05 0.58 9.68e-32 Dental caries; LUSC cis rs709400 0.663 rs11628213 chr14:103952453 A/C cg12935359 chr14:103987150 CKB -0.56 -8.67 -0.43 1.92e-16 Body mass index; LUSC cis rs829883 0.966 rs249818 chr12:98896994 A/C cg25150519 chr12:98850993 NA 0.64 9.79 0.47 4.44e-20 Colorectal adenoma (advanced); LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg18404041 chr3:52824283 ITIH1 -0.62 -12.3 -0.56 6.21e-29 Bipolar disorder; LUSC cis rs6495122 0.532 rs2470890 chr15:75047426 C/T cg10253484 chr15:75165896 SCAMP2 -0.42 -5.7 -0.3 2.69e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -6.52 -0.34 2.61e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21659725 chr3:3221576 CRBN 0.89 18.14 0.7 1.17e-51 Intelligence (multi-trait analysis); LUSC cis rs354225 0.584 rs7591231 chr2:54829596 C/G cg01766943 chr2:54829624 SPTBN1 0.46 7.3 0.37 2.1e-12 Schizophrenia; LUSC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.66 -9.9 -0.48 1.97e-20 IgG glycosylation; LUSC cis rs6733011 0.628 rs4263159 chr2:99456151 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.67 -0.3 3.08e-8 Bipolar disorder; LUSC cis rs9486719 0.843 rs976357 chr6:96849679 C/T cg06623918 chr6:96969491 KIAA0776 0.74 8.79 0.43 8.3e-17 Migraine;Coronary artery disease; LUSC cis rs453301 0.686 rs28665409 chr8:8869277 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -7.72 -0.39 1.37e-13 Joint mobility (Beighton score); LUSC cis rs477692 1.000 rs530466 chr10:131427717 A/G cg11019008 chr10:131425282 MGMT 0.42 6.43 0.33 4.42e-10 Response to temozolomide; LUSC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg09085632 chr11:111637200 PPP2R1B -1.02 -15.41 -0.64 7.4e-41 Primary sclerosing cholangitis; LUSC cis rs11214589 0.774 rs7116782 chr11:113250938 A/G cg14159747 chr11:113255604 NA 0.31 7.93 0.4 3.28e-14 Neuroticism; LUSC cis rs2227631 0.505 rs4729662 chr7:100765559 C/T cg04735437 chr7:100647879 MUC12 0.44 5.94 0.31 7.26e-9 Plasminogen activator inhibitor type 1 levels (PAI-1); LUSC trans rs61931739 0.500 rs12367292 chr12:33998075 T/C cg13010199 chr12:38710504 ALG10B 0.56 8.27 0.41 3.18e-15 Morning vs. evening chronotype; LUSC cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg24642439 chr20:33292090 TP53INP2 0.5 7.43 0.38 8.94e-13 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20317738 chr1:9749717 PIK3CD 0.46 7.26 0.37 2.72e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg24812749 chr6:127587940 RNF146 0.92 13.97 0.61 3.03e-35 Breast cancer; LUSC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.19 -0.32 1.8e-9 Major depressive disorder; LUSC cis rs11098499 0.863 rs1383532 chr4:120434404 A/T cg24375607 chr4:120327624 NA -0.72 -10.76 -0.51 2.23e-23 Corneal astigmatism; LUSC cis rs1691799 0.899 rs1168292 chr12:66732660 C/T cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.33e-31 White blood cell count (basophil); LUSC cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg13334819 chr7:99746414 C7orf59 0.44 5.86 0.31 1.08e-8 Coronary artery disease; LUSC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg04518342 chr5:131593106 PDLIM4 -0.43 -7.29 -0.37 2.32e-12 Breast cancer; LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg22920501 chr2:26401640 FAM59B -0.79 -11.61 -0.54 2.05e-26 Gut microbiome composition (summer); LUSC cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg26384229 chr12:38710491 ALG10B 0.87 14.76 0.63 2.57e-38 Bladder cancer; LUSC cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.13 0.55 2.54e-28 Colorectal cancer; LUSC cis rs59104589 0.617 rs73002170 chr2:242325980 G/A cg14842376 chr2:242211374 HDLBP 0.56 6.53 0.34 2.48e-10 Fibrinogen levels; LUSC cis rs765787 0.530 rs55920042 chr15:45541577 G/A cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.04e-16 Uric acid levels; LUSC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg08847533 chr14:75593920 NEK9 -0.8 -13.77 -0.6 1.71e-34 Height; LUSC cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.48 0.42 7.38e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs2652834 1.000 rs2652834 chr15:63396867 A/G cg05507819 chr15:63340323 TPM1 0.68 8.27 0.41 3.21e-15 HDL cholesterol; LUSC trans rs1005277 0.579 rs2800485 chr10:38542588 G/A cg17830980 chr10:43048298 ZNF37B -0.58 -9.41 -0.46 8.46e-19 Extrinsic epigenetic age acceleration; LUSC cis rs193541 0.632 rs7735618 chr5:122176245 C/G cg19077854 chr5:122220652 SNX24 0.38 8.06 0.4 1.35e-14 Glucose homeostasis traits; LUSC cis rs9487051 0.735 rs351754 chr6:109537553 A/G cg12927641 chr6:109611667 NA 0.35 5.74 0.3 2.09e-8 Reticulocyte fraction of red cells; LUSC cis rs55665837 0.539 rs12794714 chr11:14913575 G/A cg05501817 chr11:14380813 RRAS2 -0.39 -5.72 -0.3 2.41e-8 Vitamin D levels; LUSC cis rs4805272 0.512 rs8105613 chr19:29339151 C/T cg04546413 chr19:29218101 NA 0.6 7.47 0.38 6.95e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs3008870 0.583 rs2147838 chr1:67399466 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.93 13.14 0.58 4.52e-32 Lymphocyte percentage of white cells; LUSC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg23758822 chr17:41437982 NA 1.05 20.45 0.75 7.54e-61 Menopause (age at onset); LUSC trans rs7615952 0.800 rs11915699 chr3:125632684 A/G cg07211511 chr3:129823064 LOC729375 -1.2 -19.1 -0.72 1.74e-55 Blood pressure (smoking interaction); LUSC cis rs6599077 0.950 rs10510706 chr3:40100257 T/A cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs1371867 0.875 rs962451 chr8:101331010 C/T cg06636551 chr8:101224915 SPAG1 -0.44 -7.98 -0.4 2.33e-14 Atrioventricular conduction; LUSC cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.82e-13 Motion sickness; LUSC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.88 0.31 1.02e-8 Tonsillectomy; LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.39 0.53 1.26e-25 Menopause (age at onset); LUSC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg01475377 chr6:109611718 NA -0.46 -8.49 -0.42 6.94e-16 Reticulocyte fraction of red cells; LUSC cis rs9921338 0.961 rs57579443 chr16:11442997 G/C cg00044050 chr16:11439710 C16orf75 -0.5 -6.68 -0.34 1e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs6580649 0.883 rs1793955 chr12:48393106 G/T cg05342945 chr12:48394962 COL2A1 -0.44 -5.83 -0.3 1.27e-8 Lung cancer; LUSC cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.53e-9 Breast cancer; LUSC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2273669 0.504 rs77373614 chr6:109418075 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -5.92 -0.31 8e-9 Prostate cancer; LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC cis rs6840360 0.967 rs7684350 chr4:152672882 T/G cg22705602 chr4:152727874 NA -0.26 -5.7 -0.3 2.62e-8 Intelligence (multi-trait analysis); LUSC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg16545954 chr1:2118288 C1orf86 0.36 6.92 0.35 2.32e-11 Height; LUSC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg11062466 chr8:58055876 NA 0.52 7.11 0.36 7.07e-12 Developmental language disorder (linguistic errors); LUSC cis rs6906287 0.647 rs35730412 chr6:118707343 T/C cg21191810 chr6:118973309 C6orf204 0.33 5.9 0.31 9.13e-9 Electrocardiographic conduction measures; LUSC cis rs11098499 0.644 rs28787668 chr4:120554687 G/A cg09307838 chr4:120376055 NA 0.63 9.38 0.46 1.03e-18 Corneal astigmatism; LUSC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.48 6.19 0.32 1.8e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg27129171 chr3:47204927 SETD2 0.56 8.01 0.4 1.93e-14 Birth weight; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg18538332 chr22:24372958 LOC391322 -0.43 -7.73 -0.39 1.32e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6545883 0.894 rs7566035 chr2:61520815 C/T cg15711740 chr2:61764176 XPO1 0.45 6.93 0.35 2.15e-11 Tuberculosis; LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg13397359 chr6:42928475 GNMT 0.57 9.43 0.46 7.22e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.77e-9 Aortic root size; LUSC cis rs929354 0.772 rs2023975 chr7:157012096 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.69 -0.47 9.71e-20 Body mass index; LUSC cis rs9398803 0.830 rs9401885 chr6:126825837 C/G cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.97e-9 Male-pattern baldness; LUSC cis rs778371 0.723 rs34707169 chr2:233699459 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -12.4 -0.56 2.56e-29 Schizophrenia; LUSC cis rs909002 0.800 rs6703093 chr1:32093561 C/T cg01639898 chr1:32083012 HCRTR1 0.3 7.35 0.37 1.49e-12 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg08280861 chr8:58055591 NA 0.53 5.81 0.3 1.5e-8 Developmental language disorder (linguistic errors); LUSC cis rs2274273 1.000 rs3825613 chr14:55593172 A/C cg04306507 chr14:55594613 LGALS3 0.53 11.51 0.53 4.72e-26 Protein biomarker; LUSC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg19592336 chr6:28129416 ZNF389 0.48 6.29 0.33 1.02e-9 Depression; LUSC trans rs853679 0.607 rs34691223 chr6:28258208 C/A cg01620082 chr3:125678407 NA -0.78 -7.6 -0.38 3.04e-13 Depression; LUSC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.19e-9 Attention deficit hyperactivity disorder; LUSC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg09323728 chr8:95962352 TP53INP1 -0.38 -7.73 -0.39 1.24e-13 Type 2 diabetes; LUSC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg12403142 chr1:92012408 NA 0.36 5.86 0.31 1.13e-8 Breast cancer; LUSC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.65 -0.3 3.53e-8 Extrinsic epigenetic age acceleration; LUSC cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg18904891 chr8:8559673 CLDN23 0.59 8.1 0.41 1.03e-14 Obesity-related traits; LUSC cis rs2273669 0.667 rs7765732 chr6:109347057 A/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs870825 0.616 rs4437295 chr4:185643336 C/T cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs929354 0.742 rs7807556 chr7:156934329 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.03 0.58 1.16e-31 Body mass index; LUSC cis rs7043114 0.507 rs7856204 chr9:95173814 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.86 -0.35 3.33e-11 Height; LUSC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg05872129 chr22:39784769 NA -0.53 -9.57 -0.46 2.44e-19 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.61 -0.54 2.17e-26 Schizophrenia; LUSC cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg24642439 chr20:33292090 TP53INP2 -0.54 -8.12 -0.41 9.4e-15 Glomerular filtration rate (creatinine); LUSC trans rs7615952 0.576 rs4646748 chr3:125826329 G/A cg07211511 chr3:129823064 LOC729375 -0.78 -10.16 -0.49 2.55e-21 Blood pressure (smoking interaction); LUSC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg14343924 chr8:8086146 FLJ10661 -0.42 -6.16 -0.32 2.14e-9 Mood instability; LUSC trans rs1908814 0.516 rs13275143 chr8:11796990 T/A cg08975724 chr8:8085496 FLJ10661 0.47 6.66 0.34 1.14e-10 Neuroticism; LUSC cis rs765787 0.530 rs12904265 chr15:45526713 C/T cg25801113 chr15:45476975 SHF -0.34 -6.7 -0.34 9.1e-11 Uric acid levels; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.41 -6.78 -0.35 5.32e-11 Electroencephalogram traits; LUSC trans rs2235573 0.551 rs139893 chr22:38393608 G/A cg19894588 chr14:64061835 NA 0.49 7.13 0.36 6.25e-12 Glioblastoma;Glioma; LUSC cis rs73200209 0.744 rs61939697 chr12:116555491 T/C cg01776926 chr12:116560359 MED13L -0.5 -5.99 -0.31 5.44e-9 Total body bone mineral density; LUSC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg11344533 chr11:111475393 SIK2 -0.49 -6.61 -0.34 1.48e-10 Primary sclerosing cholangitis; LUSC cis rs6429082 0.755 rs291367 chr1:235690800 G/A cg26050004 chr1:235667680 B3GALNT2 0.64 8.97 0.44 2.25e-17 Adiposity; LUSC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg16405210 chr4:1374714 KIAA1530 -0.58 -9.36 -0.46 1.22e-18 Obesity-related traits; LUSC cis rs6009527 1.000 rs6009527 chr22:49570587 C/T cg12746016 chr22:49560550 NA 0.39 6.71 0.34 8.37e-11 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs9807841 0.592 rs10419865 chr19:10772685 C/G cg17710535 chr19:10819994 QTRT1 0.42 6.94 0.36 1.99e-11 Inflammatory skin disease; LUSC cis rs7918232 0.943 rs6482593 chr10:27371437 A/G cg14442939 chr10:27389572 ANKRD26 0.85 9.93 0.48 1.62e-20 Breast cancer; LUSC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg06634786 chr22:41940651 POLR3H -0.54 -6.22 -0.32 1.51e-9 Vitiligo; LUSC cis rs11190604 1.000 rs12358187 chr10:102284449 C/G cg07080220 chr10:102295463 HIF1AN 0.7 9.4 0.46 8.73e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg25456477 chr12:86230367 RASSF9 0.33 5.78 0.3 1.68e-8 Major depressive disorder; LUSC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs2115536 0.730 rs4238512 chr15:80183898 A/C cg00225070 chr15:80189496 MTHFS -0.42 -6.09 -0.32 3.03e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7200543 0.961 rs1741 chr16:15130351 G/C cg03427771 chr16:15082598 PDXDC1 -0.42 -5.85 -0.3 1.19e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg06028605 chr16:24865363 SLC5A11 0.67 9.78 0.47 5.08e-20 Intelligence (multi-trait analysis); LUSC cis rs71403859 0.554 rs12373065 chr16:71870032 T/A cg03805757 chr16:71968109 PKD1L3 -0.6 -6.36 -0.33 6.45e-10 Post bronchodilator FEV1; LUSC cis rs34779708 0.966 rs4934539 chr10:35472199 A/G cg03585969 chr10:35415529 CREM 0.63 9.32 0.45 1.68e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6967385 0.580 rs10258717 chr7:12331651 A/G cg06484146 chr7:12443880 VWDE 0.4 6.44 0.33 4.13e-10 Response to taxane treatment (placlitaxel); LUSC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg02772935 chr3:125709198 NA -0.47 -5.64 -0.3 3.55e-8 Blood pressure (smoking interaction); LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg20295408 chr7:1910781 MAD1L1 -0.51 -7.42 -0.38 1.01e-12 Bipolar disorder and schizophrenia; LUSC cis rs7681440 0.904 rs6816305 chr4:90772902 C/G cg15133208 chr4:90757351 SNCA -0.32 -5.65 -0.3 3.38e-8 Dementia with Lewy bodies; LUSC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg12463550 chr7:65579703 CRCP -0.43 -6.36 -0.33 6.61e-10 Aortic root size; LUSC cis rs7605827 0.930 rs13035283 chr2:15500939 G/C cg19274914 chr2:15703543 NA 0.45 8.46 0.42 8.55e-16 Educational attainment (years of education); LUSC cis rs7169223 0.653 rs1976007 chr15:79085023 T/C cg21242079 chr15:79101063 ADAMTS7 0.42 6.4 0.33 5.2400000000000005e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.48e-12 Motion sickness; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02018176 chr4:1364513 KIAA1530 -0.71 -13.67 -0.6 4.39e-34 Longevity; LUSC cis rs4595586 0.545 rs7973338 chr12:39380704 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs4727027 0.704 rs2269972 chr7:148914047 C/T cg23583168 chr7:148888333 NA 0.86 15.73 0.65 4.15e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs561341 1.000 rs537166 chr17:30326827 C/T cg27661571 chr11:113659931 NA -0.62 -7.41 -0.38 1.02e-12 Hip circumference adjusted for BMI; LUSC cis rs734999 0.566 rs12748729 chr1:2558740 C/T cg18932078 chr1:2524107 MMEL1 -0.31 -6.93 -0.35 2.21e-11 Ulcerative colitis; LUSC cis rs753778 0.628 rs1045248 chr8:142204326 C/G cg18755752 chr8:142205143 DENND3 -0.76 -13.61 -0.6 7.1e-34 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg22903657 chr4:1355424 KIAA1530 -0.5 -8.41 -0.42 1.23e-15 Obesity-related traits; LUSC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11890956 chr21:40555474 PSMG1 1.02 19.57 0.73 2.39e-57 Cognitive function; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg08888203 chr3:10149979 C3orf24 0.59 8.17 0.41 6.42e-15 Alzheimer's disease; LUSC cis rs6489785 0.735 rs12825746 chr12:121268033 A/C cg02403541 chr12:121454288 C12orf43 0.38 5.68 0.3 2.89e-8 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs6700896 0.864 rs11208718 chr1:66158995 G/A cg04111102 chr1:66153794 NA 0.34 7.42 0.38 1e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg13866156 chr1:1669148 SLC35E2 0.5 8.3 0.41 2.69e-15 Body mass index; LUSC cis rs3008870 0.816 rs1118392 chr1:67366549 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.8 -13.14 -0.58 4.48e-32 Lymphocyte percentage of white cells; LUSC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg07212818 chr11:638076 DRD4 -0.42 -7.15 -0.36 5.65e-12 Systemic lupus erythematosus; LUSC cis rs4319547 0.585 rs7953007 chr12:122816977 A/C cg23029597 chr12:123009494 RSRC2 -0.74 -9.29 -0.45 1.98e-18 Body mass index; LUSC cis rs738322 1.000 rs4381 chr22:38570791 T/C cg17652424 chr22:38574118 PLA2G6 -0.29 -6.41 -0.33 5e-10 Cutaneous nevi; LUSC cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg14530993 chr4:882597 GAK 0.64 6.73 0.35 7.19e-11 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg26441486 chr22:50317300 CRELD2 0.49 7.45 0.38 7.81e-13 Schizophrenia; LUSC cis rs1018836 0.884 rs13279263 chr8:91648780 T/C cg16814680 chr8:91681699 NA -0.75 -12.2 -0.56 1.45e-28 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg25517151 chr20:30467953 TTLL9 -0.42 -6.12 -0.32 2.57e-9 Hepatitis; LUSC cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg03522245 chr20:25566470 NINL 0.36 5.84 0.3 1.24e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8025790 0.508 rs12905371 chr15:67845930 C/T cg24579218 chr15:68104479 NA -0.34 -5.67 -0.3 3.08e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs10876993 0.890 rs10783844 chr12:58098425 A/C cg15848620 chr12:58087721 OS9 -0.56 -7.94 -0.4 3.09e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs4988958 0.565 rs10206291 chr2:103038863 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.35e-12 Asthma (childhood onset); LUSC cis rs12286929 0.898 rs117569901 chr11:115018509 T/G cg04055981 chr11:115044050 NA 0.35 5.93 0.31 7.44e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs3808502 0.549 rs1382563 chr8:11426790 C/G cg06636001 chr8:8085503 FLJ10661 0.6 9.29 0.45 2e-18 Neuroticism; LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.13 -0.48 3.26e-21 Electroencephalogram traits; LUSC cis rs7223966 1.000 rs7223672 chr17:61720565 T/C cg05941027 chr17:61774174 LIMD2 0.22 5.83 0.3 1.29e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2463822 1.000 rs118049526 chr11:62107508 C/T cg06239285 chr11:62104954 ASRGL1 -0.96 -10.25 -0.49 1.29e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7267979 0.816 rs390123 chr20:25480105 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.77 15.74 0.65 3.66e-42 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.89 -0.31 9.61e-9 Alzheimer's disease (late onset); LUSC cis rs3087591 0.708 rs8067440 chr17:29708155 A/T cg24425628 chr17:29625626 OMG;NF1 0.54 8.29 0.41 2.88e-15 Hip circumference; LUSC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg23490090 chr17:78081364 GAA 0.36 5.83 0.3 1.27e-8 Yeast infection; LUSC cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg07537917 chr2:241836409 C2orf54 0.26 5.94 0.31 7.33e-9 Urinary metabolites; LUSC cis rs2230307 0.536 rs57637634 chr1:100447467 G/A cg24955406 chr1:100503596 HIAT1 0.56 6.08 0.32 3.31e-9 Carotid intima media thickness; LUSC cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg04450456 chr4:17643702 FAM184B 0.35 5.77 0.3 1.81e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9788682 0.706 rs924840 chr15:78731808 A/T cg18825076 chr15:78729989 IREB2 0.46 6.44 0.33 4.18e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg17366294 chr4:99064904 C4orf37 0.5 8.81 0.43 6.78e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs17685 0.753 rs10476 chr7:75696420 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.5 7.79 0.39 8.3e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7582720 1.000 rs77931721 chr2:203763076 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.66 0.43 2.06e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4901869 1.000 rs4901869 chr14:59334128 A/G cg02291164 chr14:59296302 NA 0.57 10.93 0.51 5.74e-24 Panic disorder; LUSC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg12863693 chr15:85201151 NMB -0.25 -5.75 -0.3 2.07e-8 Schizophrenia; LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg22920501 chr2:26401640 FAM59B 0.76 9.87 0.48 2.47e-20 Gut microbiome composition (summer); LUSC cis rs9581857 0.547 rs9579096 chr13:28084069 T/C cg22138327 chr13:27999177 GTF3A 0.69 7.15 0.36 5.44e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs34638657 0.500 rs12446210 chr16:82185762 G/A cg09439754 chr16:82129088 HSD17B2 -0.36 -6.52 -0.34 2.52e-10 Lung adenocarcinoma; LUSC cis rs1371867 0.875 rs1788173 chr8:101330939 A/G cg06636551 chr8:101224915 SPAG1 0.36 6.68 0.34 9.77e-11 Atrioventricular conduction; LUSC trans rs17807624 0.964 rs13249843 chr8:11459018 G/T cg15556689 chr8:8085844 FLJ10661 0.54 7.79 0.39 8.77e-14 Systemic lupus erythematosus; LUSC cis rs34779708 0.931 rs11592404 chr10:35273476 G/A cg03585969 chr10:35415529 CREM 0.66 9.47 0.46 5.19e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg20406979 chr6:167373233 NA -0.26 -6.07 -0.32 3.4e-9 Crohn's disease; LUSC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.47 -8.63 -0.43 2.6e-16 Total body bone mineral density; LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg14092988 chr3:52407081 DNAH1 0.32 6.25 0.32 1.27e-9 Bipolar disorder; LUSC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg06640241 chr16:89574553 SPG7 0.72 11.3 0.53 2.63e-25 Multiple myeloma (IgH translocation); LUSC cis rs11051970 1.000 rs6488051 chr12:32532733 G/C cg24626660 chr12:32551988 NA 0.37 6.12 0.32 2.64e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs806215 1.000 rs806215 chr7:127237312 T/C cg25922125 chr7:127225783 GCC1 -0.57 -7.18 -0.37 4.7e-12 Type 2 diabetes; LUSC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg06481639 chr22:41940642 POLR3H -0.53 -6.08 -0.32 3.24e-9 Vitiligo; LUSC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg05855489 chr10:104503620 C10orf26 0.54 8.09 0.4 1.14e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2797160 1.000 rs1739352 chr6:126005310 T/C cg05901451 chr6:126070800 HEY2 -0.58 -8.59 -0.43 3.43e-16 Endometrial cancer; LUSC cis rs4964805 0.612 rs11111758 chr12:104161084 A/G cg02344784 chr12:104178138 NT5DC3 0.37 5.94 0.31 7.35e-9 Attention deficit hyperactivity disorder; LUSC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg14196790 chr5:131705035 SLC22A5 -0.52 -9.13 -0.45 6.49e-18 Blood metabolite levels; LUSC cis rs3784262 1.000 rs3204689 chr15:58246802 G/C cg12031962 chr15:58353849 ALDH1A2 -0.34 -6.22 -0.32 1.52e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg17644776 chr2:200775616 C2orf69 0.5 8.62 0.43 2.71e-16 Osteoporosis; LUSC cis rs4073582 0.595 rs801741 chr11:65917084 A/G cg16950941 chr11:66035639 RAB1B 0.51 7.46 0.38 7.47e-13 Gout; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg11905131 chr22:24372483 LOC391322 -0.51 -8.39 -0.42 1.37e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12980942 0.935 rs1865051 chr19:41824885 T/C cg25627403 chr19:41769009 HNRNPUL1 0.56 6.05 0.31 3.87e-9 Coronary artery disease; LUSC trans rs6981523 0.553 rs11783045 chr8:11056175 A/G cg08975724 chr8:8085496 FLJ10661 -0.47 -6.4 -0.33 5.41e-10 Neuroticism; LUSC cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg00012203 chr2:219082015 ARPC2 -0.57 -9.16 -0.45 5.27e-18 Ulcerative colitis; LUSC cis rs477692 1.000 rs513736 chr10:131406489 C/T cg26102564 chr10:131424627 MGMT 0.42 6.69 0.34 9.38e-11 Response to temozolomide; LUSC cis rs7127129 0.503 rs7105001 chr11:70051949 T/C cg06159181 chr11:70072977 NA -0.27 -6.75 -0.35 6.44e-11 Aortic root size; LUSC cis rs894344 0.650 rs55675081 chr8:135582032 C/A cg17885191 chr8:135476712 NA 0.4 5.65 0.3 3.45e-8 Systolic blood pressure; LUSC cis rs9399135 0.869 rs9402675 chr6:135325794 C/G cg22676075 chr6:135203613 NA 0.48 7.48 0.38 6.5e-13 Red blood cell count; LUSC cis rs2274273 0.837 rs7142857 chr14:55704128 C/T cg04306507 chr14:55594613 LGALS3 0.58 13.66 0.6 4.84e-34 Protein biomarker; LUSC cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg05283184 chr6:79620031 NA -0.46 -8.63 -0.43 2.52e-16 Intelligence (multi-trait analysis); LUSC trans rs6076960 0.622 rs6054063 chr20:6262992 C/A cg17788362 chr6:86352627 SYNCRIP 0.47 7.14 0.36 5.94e-12 Smooth-surface caries; LUSC trans rs1223397 0.938 rs17767967 chr6:13282067 C/T cg13974761 chr1:152670598 LCE2A 0.36 5.95 0.31 6.67e-9 Blood pressure; LUSC cis rs8133932 0.608 rs373267 chr21:47343320 G/T cg14185626 chr21:47401492 COL6A1 -0.44 -5.78 -0.3 1.74e-8 Schizophrenia; LUSC cis rs1568889 1.000 rs34667360 chr11:28055650 T/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 8.94 0.44 2.63e-17 Bipolar disorder; LUSC trans rs9291683 0.530 rs4235346 chr4:9945296 C/T cg26043149 chr18:55253948 FECH -0.42 -6.12 -0.32 2.67e-9 Bone mineral density; LUSC cis rs7193541 0.694 rs8061942 chr16:74691362 C/T cg01733217 chr16:74700730 RFWD3 0.97 22.18 0.77 1.26e-67 Multiple myeloma; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg11060661 chr22:24314208 DDT;DDTL 0.43 7.22 0.37 3.58e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs208520 1.000 rs72882079 chr6:66973878 T/C cg07460842 chr6:66804631 NA 0.95 12.31 0.56 5.59e-29 Exhaled nitric oxide output; LUSC cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs10789491 1.000 rs4553120 chr1:47165729 C/T cg15501359 chr1:47185051 KIAA0494 0.81 11.47 0.53 6.7e-26 Response to hepatitis C treatment; LUSC cis rs1577917 0.771 rs4383777 chr6:86435960 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.65 10.3 0.49 8.73e-22 Response to antipsychotic treatment; LUSC cis rs7923609 0.812 rs10761753 chr10:65161903 G/A cg01631684 chr10:65280961 REEP3 -0.42 -6.47 -0.33 3.48e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6500395 0.775 rs4277341 chr16:48664387 T/G cg04672837 chr16:48644449 N4BP1 0.47 7.01 0.36 1.36e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs7773004 0.601 rs13210340 chr6:26326314 G/C cg09904177 chr6:26538194 HMGN4 -0.75 -5.74 -0.3 2.14e-8 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1568889 0.548 rs34906813 chr11:28508819 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.5 5.86 0.31 1.13e-8 Bipolar disorder; LUSC cis rs12681287 0.752 rs4472493 chr8:87251914 C/T cg27223183 chr8:87520930 FAM82B -0.45 -5.76 -0.3 1.87e-8 Caudate activity during reward; LUSC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg14298792 chr15:30685198 CHRFAM7A 0.64 8.34 0.42 1.96e-15 Huntington's disease progression; LUSC cis rs7829975 0.623 rs7010753 chr8:8373956 A/G cg15556689 chr8:8085844 FLJ10661 0.65 10.48 0.5 2.05e-22 Mood instability; LUSC cis rs11955175 0.717 rs41271053 chr5:40835393 A/C cg05478818 chr5:40835740 RPL37 0.76 5.86 0.31 1.08e-8 Bipolar disorder and schizophrenia; LUSC cis rs12210905 0.688 rs114157955 chr6:27329878 C/T cg08851530 chr6:28072375 NA 0.9 5.78 0.3 1.75e-8 Hip circumference adjusted for BMI; LUSC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.76 -0.3 1.96e-8 Testicular germ cell tumor; LUSC cis rs4722404 0.570 rs1968924 chr7:3137677 G/T cg19214707 chr7:3157722 NA -0.36 -6.92 -0.35 2.28e-11 Atopic dermatitis; LUSC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg07148914 chr20:33460835 GGT7 0.39 5.77 0.3 1.82e-8 Coronary artery disease; LUSC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2274273 0.870 rs10144345 chr14:55847737 T/C cg04306507 chr14:55594613 LGALS3 0.56 12.97 0.58 2.02e-31 Protein biomarker; LUSC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg11189052 chr15:85197271 WDR73 0.47 5.66 0.3 3.24e-8 Schizophrenia; LUSC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg08392591 chr16:89556376 ANKRD11 0.52 8.13 0.41 8.62e-15 Multiple myeloma (IgH translocation); LUSC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg04414720 chr1:150670196 GOLPH3L 0.5 7.86 0.4 5.27e-14 Melanoma; LUSC cis rs7772486 0.875 rs2777481 chr6:146310036 G/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.12 -0.36 6.7e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 1.000 rs10236397 chr7:91691601 C/T cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs11122272 0.735 rs11122281 chr1:231519842 A/G cg06096015 chr1:231504339 EGLN1 0.57 9.97 0.48 1.16e-20 Hemoglobin concentration; LUSC cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg12310025 chr6:25882481 NA -0.51 -9.34 -0.45 1.44e-18 Blood metabolite levels; LUSC cis rs12190007 0.547 rs3006178 chr6:169823936 G/A cg15038512 chr6:170123185 PHF10 -0.39 -6.26 -0.32 1.16e-9 Obesity-related traits; LUSC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.74 0.6 2.33e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg15704280 chr7:45808275 SEPT13 -0.84 -13.98 -0.61 2.84e-35 Height; LUSC cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg05985134 chr18:33552581 C18orf21 -0.52 -7.31 -0.37 2e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC trans rs7937682 0.961 rs1784784 chr11:111483185 C/T cg18187862 chr3:45730750 SACM1L 0.54 7.05 0.36 1.02e-11 Primary sclerosing cholangitis; LUSC cis rs2425143 0.908 rs11697087 chr20:34427583 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -6.3 -0.33 9.6e-10 Blood protein levels; LUSC trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg03929089 chr4:120376271 NA -0.45 -6.12 -0.32 2.58e-9 HDL cholesterol; LUSC cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg12935359 chr14:103987150 CKB -0.65 -10.61 -0.5 7.5e-23 Intelligence (multi-trait analysis); LUSC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg00033643 chr7:134001901 SLC35B4 0.44 6.75 0.35 6.5500000000000006e-11 Mean platelet volume; LUSC trans rs11935423 0.778 rs11933250 chr4:100491509 T/C cg02164153 chr5:172068145 NEURL1B -0.47 -6.1 -0.32 3e-9 Gut microbiome composition (summer); LUSC cis rs7827545 0.545 rs16905172 chr8:135556373 A/G cg17885191 chr8:135476712 NA 0.61 7.83 0.39 6.53e-14 Hypertension (SNP x SNP interaction); LUSC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.68 -0.43 1.83e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs8078723 0.510 rs11655264 chr17:38138995 G/C cg17467752 chr17:38218738 THRA -0.53 -8.03 -0.4 1.68e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs936229 0.813 rs72730503 chr15:75086386 G/A cg10253484 chr15:75165896 SCAMP2 -0.51 -6.65 -0.34 1.19e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg12463550 chr7:65579703 CRCP -0.55 -8.23 -0.41 4.27e-15 Aortic root size; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg16362232 chr11:430036 ANO9 0.63 8.24 0.41 3.85e-15 Body mass index; LUSC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg18681998 chr4:17616180 MED28 0.85 15.67 0.65 6.85e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg11494091 chr17:61959527 GH2 0.7 15.04 0.64 2.08e-39 Prudent dietary pattern; LUSC cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.44e-23 Bladder cancer; LUSC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg07061783 chr6:25882402 NA -0.49 -6.49 -0.33 3.13e-10 Intelligence (multi-trait analysis); LUSC cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.7 -0.3 2.67e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs9287719 0.967 rs4405729 chr2:10755779 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg18904891 chr8:8559673 CLDN23 0.58 8.07 0.4 1.25e-14 Obesity-related traits; LUSC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg00409905 chr10:38381863 ZNF37A 0.36 6.23 0.32 1.4e-9 Extrinsic epigenetic age acceleration; LUSC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg17385448 chr1:15911702 AGMAT 0.35 5.92 0.31 7.87e-9 Systolic blood pressure; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg25767906 chr1:53392781 SCP2 0.53 9.76 0.47 5.75e-20 Monocyte count; LUSC cis rs6964587 0.967 rs410 chr7:91557425 C/G cg17063962 chr7:91808500 NA -0.57 -8.76 -0.43 9.79e-17 Breast cancer; LUSC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg16928487 chr17:17741425 SREBF1 0.37 7.13 0.36 6.28e-12 Total body bone mineral density; LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg19318889 chr4:1322082 MAEA -0.71 -12.08 -0.55 3.97e-28 Obesity-related traits; LUSC cis rs9807989 0.839 rs13392100 chr2:102982094 C/A cg09003973 chr2:102972529 NA 0.44 6.04 0.31 4.11e-9 Asthma; LUSC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg11764359 chr7:65958608 NA 0.61 9.2 0.45 3.91e-18 Calcium levels; LUSC cis rs9902453 0.904 rs4567782 chr17:28268800 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.79 0.51 1.7e-23 Coffee consumption (cups per day); LUSC cis rs73001065 0.591 rs2285626 chr19:19467545 C/T cg03709012 chr19:19516395 GATAD2A 1.06 10.79 0.51 1.69e-23 LDL cholesterol; LUSC cis rs9287719 0.967 rs10206225 chr2:10758657 A/G cg03983476 chr2:10830698 NOL10 -0.37 -5.71 -0.3 2.56e-8 Prostate cancer; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg12432903 chr7:1882776 MAD1L1 -0.5 -8.51 -0.42 6.04e-16 Bipolar disorder and schizophrenia; LUSC cis rs1003719 0.788 rs2835602 chr21:38469069 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg08645402 chr16:4508243 NA 0.49 7.73 0.39 1.25e-13 Schizophrenia; LUSC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg18876405 chr7:65276391 NA 0.68 12.09 0.55 3.69e-28 Aortic root size; LUSC cis rs4409675 0.597 rs1000431 chr1:28225114 C/T cg23691781 chr1:28212827 C1orf38 0.31 7.43 0.38 9.31e-13 Corneal astigmatism; LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.89 -0.31 9.55e-9 Platelet count; LUSC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg13206674 chr6:150067644 NUP43 0.6 9.55 0.46 2.91e-19 Lung cancer; LUSC cis rs9420 0.961 rs11604325 chr11:57497011 C/A cg02958346 chr11:57425731 CLP1 -0.43 -6.28 -0.32 1.06e-9 Schizophrenia; LUSC cis rs4852324 0.541 rs7568898 chr2:74271577 C/T cg19729930 chr2:74357872 NA 0.54 6.14 0.32 2.32e-9 Systemic lupus erythematosus; LUSC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg17376030 chr22:41985996 PMM1 -0.48 -6.02 -0.31 4.57e-9 Vitiligo; LUSC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.24e-21 Bipolar disorder; LUSC cis rs6964587 1.000 rs12333563 chr7:91667326 G/A cg22709100 chr7:91322751 NA 0.39 5.79 0.3 1.64e-8 Breast cancer; LUSC cis rs9653442 0.648 rs11123805 chr2:100643464 A/G cg07810366 chr2:100720526 AFF3 -0.42 -7.11 -0.36 7.19e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs10751667 0.643 rs10794352 chr11:946294 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.44 0.33 4.21e-10 Alzheimer's disease (late onset); LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg16405210 chr4:1374714 KIAA1530 -0.52 -7.73 -0.39 1.25e-13 Obesity-related traits; LUSC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg00784671 chr22:46762841 CELSR1 -0.6 -6.92 -0.35 2.34e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs6554196 0.508 rs10488849 chr4:55510862 C/T cg18836493 chr4:55524333 KIT -0.41 -7.1 -0.36 7.66e-12 Monocyte count; LUSC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg16262614 chr3:133464971 TF 0.43 7.54 0.38 4.61e-13 Iron status biomarkers (transferrin levels); LUSC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg11812906 chr14:75593930 NEK9 -0.65 -10.73 -0.51 2.9e-23 Height; LUSC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.39 -0.38 1.15e-12 Alzheimer's disease (late onset); LUSC cis rs17818399 0.547 rs62134736 chr2:46766446 G/A cg02822958 chr2:46747628 ATP6V1E2 0.45 6.44 0.33 4.14e-10 Height; LUSC cis rs1670533 0.872 rs11727135 chr4:1051803 G/C cg27284194 chr4:1044797 NA 0.55 7.97 0.4 2.57e-14 Recombination rate (females); LUSC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg08968635 chr6:28129556 ZNF389 0.44 5.92 0.31 8.12e-9 Parkinson's disease; LUSC cis rs4555082 0.834 rs4412909 chr14:105759226 T/C cg13114125 chr14:105738426 BRF1 -0.87 -14.38 -0.62 8.24e-37 Mean platelet volume;Platelet distribution width; LUSC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg17252645 chr8:143867129 LY6D 0.45 8.13 0.41 8.71e-15 Urinary tract infection frequency; LUSC cis rs1045714 0.895 rs4719602 chr7:2647800 G/A cg24848437 chr7:2645542 IQCE 0.6 6.81 0.35 4.66e-11 Urate levels in lean individuals; LUSC cis rs7020830 0.867 rs1472169 chr9:37209396 C/T cg14294708 chr9:37120828 ZCCHC7 1.06 24.19 0.8 2.16e-75 Schizophrenia; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg22638593 chr5:131593259 PDLIM4 0.4 6.37 0.33 6.11e-10 Blood metabolite levels; LUSC trans rs7824557 0.606 rs1435277 chr8:11196970 C/T cg08975724 chr8:8085496 FLJ10661 0.49 7.08 0.36 8.68e-12 Retinal vascular caliber; LUSC cis rs887829 0.588 rs4663969 chr2:234655313 C/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -8.84 -0.44 5.44e-17 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs11809207 0.857 rs11247866 chr1:26517794 A/G cg00147160 chr1:26503991 CNKSR1 0.41 6.77 0.35 5.87e-11 Height; LUSC cis rs4619890 0.528 rs62289339 chr4:7878981 C/G cg24250820 chr4:7887609 AFAP1 0.36 6.1 0.32 2.86e-9 Glaucoma (primary open-angle); LUSC cis rs3806843 0.521 rs246061 chr5:140324656 C/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7793919 0.726 rs10261971 chr7:4776547 A/G cg09789173 chr7:4769017 FOXK1 0.66 12.3 0.56 6.2e-29 Mosquito bite size; LUSC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg21963583 chr11:68658836 MRPL21 0.55 8.28 0.41 3.08e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4242434 0.672 rs10110443 chr8:22484296 C/G cg03733263 chr8:22462867 KIAA1967 0.77 12.58 0.57 5.68e-30 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2295359 1.000 rs11465753 chr1:67631423 T/C cg12940439 chr1:67600707 NA 0.37 6.25 0.32 1.22e-9 Psoriasis; LUSC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg15448220 chr1:150897856 SETDB1 -0.42 -5.93 -0.31 7.71e-9 Melanoma; LUSC cis rs62400317 0.859 rs10456549 chr6:45225761 C/T cg20913747 chr6:44695427 NA -0.47 -7.79 -0.39 8.69e-14 Total body bone mineral density; LUSC cis rs354225 0.544 rs4641979 chr2:54811917 G/A cg26097391 chr2:54893211 SPTBN1 0.42 6.35 0.33 6.88e-10 Schizophrenia; LUSC cis rs1832871 0.683 rs9459852 chr6:158687250 T/G cg07165851 chr6:158734300 TULP4 0.5 7.72 0.39 1.41e-13 Height; LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.16 0.77 1.43e-67 Prudent dietary pattern; LUSC trans rs1994135 0.647 rs66542958 chr12:33695385 T/G cg26384229 chr12:38710491 ALG10B 0.67 9.39 0.46 9.49e-19 Resting heart rate; LUSC cis rs12760731 0.565 rs10913516 chr1:178169493 G/A cg00404053 chr1:178313656 RASAL2 0.68 6.86 0.35 3.3e-11 Obesity-related traits; LUSC cis rs2346177 0.576 rs1530621 chr2:46688688 T/C cg02822958 chr2:46747628 ATP6V1E2 0.51 8.87 0.44 4.42e-17 HDL cholesterol; LUSC cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg00012203 chr2:219082015 ARPC2 -0.58 -9.35 -0.46 1.33e-18 Ulcerative colitis; LUSC cis rs7799006 1.000 rs7810970 chr7:2276385 A/G cg08027265 chr7:2291960 NA -0.42 -7.33 -0.37 1.77e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg11965913 chr1:205819406 PM20D1 1.04 27.09 0.83 2.57e-86 Menarche (age at onset); LUSC cis rs11711311 0.747 rs11928494 chr3:113343219 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.98 -0.31 5.73e-9 IgG glycosylation; LUSC cis rs1577917 0.771 rs4351223 chr6:86237797 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 10.61 0.5 7.62e-23 Response to antipsychotic treatment; LUSC cis rs6496667 0.510 rs16944405 chr15:90975517 A/G cg10434728 chr15:90938212 IQGAP1 0.33 6.24 0.32 1.32e-9 Rheumatoid arthritis; LUSC cis rs11112613 0.713 rs11112589 chr12:105951226 C/G cg03607813 chr12:105948248 NA -0.78 -11.88 -0.54 2.25e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg01420254 chr6:26195488 NA 0.65 7.28 0.37 2.44e-12 Gout;Renal underexcretion gout; LUSC trans rs7819412 0.745 rs4841498 chr8:10985432 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.81 -0.35 4.45e-11 Triglycerides; LUSC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg24060327 chr5:131705240 SLC22A5 -0.48 -7.07 -0.36 8.85e-12 Breast cancer; LUSC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg26061582 chr7:22766209 IL6 0.48 6.9 0.35 2.61e-11 Lung cancer; LUSC trans rs2905347 0.726 rs2961294 chr7:22695031 T/C cg09038599 chr8:57233391 SDR16C5 -0.28 -6.11 -0.32 2.84e-9 Major depression and alcohol dependence; LUSC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg04317338 chr11:64019027 PLCB3 0.68 7.7 0.39 1.52e-13 Mean platelet volume; LUSC cis rs1355223 0.583 rs1828298 chr11:34870439 A/G cg24088639 chr11:34937564 PDHX;APIP -0.46 -6.84 -0.35 3.81e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7712401 0.623 rs7723798 chr5:122369717 C/G cg19077854 chr5:122220652 SNX24 0.33 6.84 0.35 3.76e-11 Mean platelet volume; LUSC cis rs1371867 0.846 rs924057 chr8:101266157 A/G cg06636551 chr8:101224915 SPAG1 0.38 7.02 0.36 1.23e-11 Atrioventricular conduction; LUSC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg09877947 chr5:131593287 PDLIM4 0.38 6.15 0.32 2.27e-9 Breast cancer;Mosquito bite size; LUSC cis rs478304 0.718 rs1144789 chr11:65389631 A/G cg27068330 chr11:65405492 SIPA1 0.67 9.61 0.47 1.79e-19 Acne (severe); LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.1 0.52 1.4e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6969780 0.778 rs61384251 chr7:27146202 A/G cg26364809 chr7:27145159 NA -0.61 -6.12 -0.32 2.68e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg16325326 chr1:53192061 ZYG11B 0.96 18.57 0.71 2.3e-53 Monocyte count; LUSC cis rs8077889 0.703 rs231531 chr17:41946180 A/C cg26893861 chr17:41843967 DUSP3 0.81 10.69 0.51 3.78e-23 Triglycerides; LUSC cis rs7829975 0.742 rs882462 chr8:8678530 G/A cg15556689 chr8:8085844 FLJ10661 0.67 10.64 0.5 6.05e-23 Mood instability; LUSC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg00129232 chr17:37814104 STARD3 -0.5 -7.43 -0.38 9.42e-13 Asthma; LUSC cis rs259282 0.524 rs11878322 chr19:33122886 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.79 12.62 0.57 4.15e-30 Schizophrenia; LUSC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.66 0.34 1.11e-10 Glioblastoma; LUSC cis rs62408225 0.722 rs3734660 chr6:90916345 A/G cg06866423 chr6:90926672 BACH2 0.41 6.45 0.33 3.95e-10 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg01017244 chr2:74357527 NA 0.69 13.39 0.59 5.1e-33 Gestational age at birth (maternal effect); LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.88 0.63 8.88e-39 Platelet count; LUSC cis rs6484504 0.600 rs942272 chr11:31364368 C/T cg06552810 chr11:31128660 NA 0.39 6.74 0.35 7.04e-11 Red blood cell count; LUSC cis rs7833986 0.501 rs2976018 chr8:57014752 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.16 0.55 1.98e-28 Height; LUSC cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg18252515 chr7:66147081 NA -0.58 -7.99 -0.4 2.16e-14 Corneal structure; LUSC cis rs9790314 0.521 rs1450522 chr3:161077630 A/G cg03342759 chr3:160939853 NMD3 -0.51 -7.03 -0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs4319547 0.626 rs12423420 chr12:122938466 G/A cg05707623 chr12:122985044 ZCCHC8 -0.6 -7.56 -0.38 3.82e-13 Body mass index; LUSC cis rs2637266 1.000 rs1907314 chr10:78337948 G/A cg18941641 chr10:78392320 NA 0.36 6.52 0.34 2.66e-10 Pulmonary function; LUSC cis rs6570726 0.902 rs973855 chr6:145781850 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -6.57 -0.34 1.97e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs11209002 0.738 rs10789222 chr1:67566651 C/T cg02640540 chr1:67518911 SLC35D1 0.65 6.48 0.33 3.32e-10 Crohn's disease; LUSC trans rs1325195 0.840 rs2793816 chr1:179244723 C/T cg11624085 chr17:8464688 MYH10 0.38 6.14 0.32 2.29e-9 IgE grass sensitization; LUSC cis rs208520 0.874 rs208518 chr6:66948501 C/G cg07460842 chr6:66804631 NA 0.96 13.89 0.61 6.2e-35 Exhaled nitric oxide output; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg20295408 chr7:1910781 MAD1L1 -0.48 -6.77 -0.35 5.92e-11 Bipolar disorder and schizophrenia; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg09436375 chr6:42928200 GNMT -0.3 -6.8 -0.35 4.73e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs9650657 0.538 rs11250093 chr8:10798828 C/T cg15556689 chr8:8085844 FLJ10661 0.53 7.41 0.38 1.05e-12 Neuroticism; LUSC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs2055729 0.645 rs12543996 chr8:9742666 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -6.72 -0.35 8.04e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs4604732 0.536 rs4433437 chr1:247636580 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.47 7.12 0.36 6.71e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs4332037 0.707 rs62435130 chr7:1890002 C/T cg10840412 chr1:235813424 GNG4 0.45 5.96 0.31 6.57e-9 Bipolar disorder; LUSC cis rs16937 0.711 rs6682229 chr1:205152932 T/C cg00857998 chr1:205179979 DSTYK 0.46 6.47 0.33 3.46e-10 Schizophrenia; LUSC cis rs8060686 0.516 rs255052 chr16:68024995 C/T cg27539214 chr16:67997921 SLC12A4 -0.47 -6.24 -0.32 1.3e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg08859206 chr1:53392774 SCP2 0.5 8.67 0.43 1.9e-16 Monocyte count; LUSC cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg06552810 chr11:31128660 NA 0.42 7.32 0.37 1.89e-12 Bone mineral density (spine); LUSC cis rs34330 0.562 rs10492235 chr12:12851339 T/G cg04607235 chr12:12878440 APOLD1 -0.56 -6.38 -0.33 5.81e-10 Systemic lupus erythematosus; LUSC cis rs6121246 0.567 rs6058189 chr20:30192389 A/G cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.2e-10 Mean corpuscular hemoglobin; LUSC trans rs2204008 0.576 rs11519979 chr12:37999413 C/T cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.53e-9 Bladder cancer; LUSC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg26769984 chr7:1090371 C7orf50 0.54 7.3 0.37 2.06e-12 Bronchopulmonary dysplasia; LUSC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg11244672 chr19:19639970 YJEFN3 -0.58 -7.38 -0.37 1.27e-12 Bipolar disorder; LUSC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.59 -0.38 3.19e-13 Developmental language disorder (linguistic errors); LUSC cis rs73206853 0.841 rs59698293 chr12:111054455 C/G cg12870014 chr12:110450643 ANKRD13A 0.69 6.51 0.34 2.76e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1419980 0.673 rs12146828 chr12:7739341 C/G cg10578777 chr12:7781093 NA -0.6 -6.58 -0.34 1.82e-10 HDL cholesterol levels; LUSC cis rs34779708 0.733 rs4298846 chr10:35547380 A/G cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6582630 0.560 rs11504462 chr12:38440379 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.33 -0.41 2.17e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs28785552 0.769 rs28796114 chr19:53234319 T/C cg10871876 chr19:53194124 ZNF83 0.55 8.31 0.41 2.36e-15 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs6598955 0.671 rs17257176 chr1:26578233 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg00012203 chr2:219082015 ARPC2 0.81 14.2 0.61 3.83e-36 Colorectal cancer; LUSC cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg06671706 chr8:8559999 CLDN23 0.49 6.61 0.34 1.48e-10 Obesity-related traits; LUSC cis rs3812831 0.695 rs7995986 chr13:114938802 A/G cg15896084 chr13:114927664 NA 0.38 6.85 0.35 3.54e-11 Schizophrenia; LUSC cis rs3960554 0.610 rs10265696 chr7:75766712 G/A cg17325771 chr7:75508891 RHBDD2 -0.42 -5.86 -0.31 1.11e-8 Eotaxin levels; LUSC cis rs11158026 0.662 rs28481699 chr14:55406549 A/T cg04306507 chr14:55594613 LGALS3 0.35 6.67 0.34 1.07e-10 Parkinson's disease; LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.09 0.61 1.02e-35 Platelet count; LUSC cis rs7216064 1.000 rs1976054 chr17:65833224 T/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.39 -0.46 9.68e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs62103177 0.525 rs62101233 chr18:77724288 C/T cg02751453 chr18:77725136 HSBP1L1 -0.48 -6.31 -0.33 8.81e-10 Opioid sensitivity; LUSC cis rs7215564 0.908 rs9908112 chr17:78753455 A/G cg06153925 chr17:78755379 RPTOR -0.38 -5.75 -0.3 2e-8 Myopia (pathological); LUSC trans rs35110281 0.592 rs6417729 chr21:44967202 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.74 0.54 6.94e-27 Mean corpuscular volume; LUSC cis rs17102423 0.533 rs3783715 chr14:65490018 C/G cg11161011 chr14:65562177 MAX -0.73 -9.89 -0.48 2.06e-20 Obesity-related traits; LUSC cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg06462663 chr19:18546047 ISYNA1 0.49 8.24 0.41 3.89e-15 Breast cancer; LUSC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg07636037 chr3:49044803 WDR6 1.04 18.76 0.72 4.04e-54 Parkinson's disease; LUSC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg23630131 chr7:65973040 NA 0.2 5.66 0.3 3.3e-8 Aortic root size; LUSC trans rs1459104 0.789 rs12802739 chr11:54899892 A/G cg15704280 chr7:45808275 SEPT13 0.69 5.97 0.31 6.07e-9 Body mass index; LUSC cis rs2742234 0.955 rs2503865 chr10:43659536 C/T cg15436174 chr10:43711423 RASGEF1A -0.36 -6.63 -0.34 1.38e-10 Hirschsprung disease; LUSC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg08975724 chr8:8085496 FLJ10661 -0.51 -7.53 -0.38 4.66e-13 Mood instability; LUSC cis rs7098414 0.511 rs7899513 chr10:82150559 G/A cg00277334 chr10:82204260 NA -0.55 -8.94 -0.44 2.71e-17 Post bronchodilator FEV1; LUSC cis rs1348850 0.597 rs13014417 chr2:178417835 T/G cg22681709 chr2:178499509 PDE11A -0.4 -6.11 -0.32 2.72e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.21 -0.37 3.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg04518342 chr5:131593106 PDLIM4 0.33 5.96 0.31 6.57e-9 Blood metabolite levels; LUSC cis rs2404602 0.684 rs12437981 chr15:76842401 A/G cg23625390 chr15:77176239 SCAPER -0.67 -10.17 -0.49 2.38e-21 Blood metabolite levels; LUSC cis rs16854884 0.657 rs1979910 chr3:143710268 A/C cg06585982 chr3:143692056 C3orf58 0.49 7.6 0.38 3.11e-13 Economic and political preferences (feminism/equality); LUSC cis rs9402673 0.517 rs978036 chr6:135342903 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.14 0.45 6.29e-18 Reticulocyte count;High light scatter reticulocyte count; LUSC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.24e-21 Bipolar disorder; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg23131131 chr22:24373011 LOC391322 -0.5 -7.08 -0.36 8.31e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1997103 0.954 rs2177809 chr7:55378125 T/C cg17469321 chr7:55412551 NA 0.68 10.8 0.51 1.59e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7617773 0.779 rs11718329 chr3:48309828 C/G cg11946769 chr3:48343235 NME6 0.88 14.27 0.62 2.16e-36 Coronary artery disease; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg14893161 chr1:205819251 PM20D1 -0.56 -8.92 -0.44 3.17e-17 Menarche (age at onset); LUSC cis rs2540226 0.844 rs727376 chr2:40000487 T/G cg23576258 chr2:39999331 THUMPD2 0.33 5.7 0.3 2.68e-8 Personality dimensions; LUSC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg14004847 chr7:1930337 MAD1L1 -0.56 -8.44 -0.42 9.92e-16 Schizophrenia; LUSC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4595586 0.545 rs12821810 chr12:39375858 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs7605827 0.836 rs4396685 chr2:15634407 C/T cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.74e-17 Educational attainment (years of education); LUSC cis rs7843479 0.601 rs878873 chr8:21834581 T/C cg17168535 chr8:21777572 XPO7 0.86 15.91 0.66 8.28e-43 Mean corpuscular volume; LUSC cis rs694739 0.796 rs479777 chr11:64107477 A/G cg02228329 chr11:64053129 BAD;GPR137 0.51 7.32 0.37 1.89e-12 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.5 -6.8 -0.35 4.9e-11 Renal function-related traits (BUN); LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg26314531 chr2:26401878 FAM59B -0.7 -9.75 -0.47 6.29e-20 Gut microbiome composition (summer); LUSC cis rs4776059 0.798 rs4774634 chr15:52872488 G/C cg25063058 chr15:52860530 ARPP19 0.48 6.46 0.33 3.6e-10 Schizophrenia; LUSC cis rs6714710 0.663 rs71429376 chr2:98534412 T/C cg26665480 chr2:98280029 ACTR1B 0.57 8.31 0.41 2.48e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg20283391 chr11:68216788 NA 0.57 8.08 0.4 1.17e-14 Total body bone mineral density; LUSC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg04871131 chr7:94954202 PON1 -0.37 -5.98 -0.31 5.79e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9325144 0.560 rs1843910 chr12:38677408 T/C cg26384229 chr12:38710491 ALG10B -0.67 -10.45 -0.5 2.68e-22 Morning vs. evening chronotype; LUSC cis rs1865760 0.865 rs9467641 chr6:25947236 T/C cg12310025 chr6:25882481 NA -0.34 -5.68 -0.3 2.91e-8 Height; LUSC trans rs6598955 0.671 rs7551557 chr1:26596614 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.69 -0.43 1.6e-16 Obesity-related traits; LUSC cis rs6964587 0.934 rs12531561 chr7:91707780 A/G cg22709100 chr7:91322751 NA 0.41 5.94 0.31 7.08e-9 Breast cancer; LUSC cis rs11158026 0.757 rs8013521 chr14:55413725 G/C cg04306507 chr14:55594613 LGALS3 0.34 6.34 0.33 7.42e-10 Parkinson's disease; LUSC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg24675658 chr1:53192096 ZYG11B 0.72 11.94 0.55 1.36e-27 Monocyte count; LUSC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg04414720 chr1:150670196 GOLPH3L 0.53 8.33 0.41 2.16e-15 Melanoma; LUSC cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg03146154 chr1:46216737 IPP 0.55 8.21 0.41 5.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4363385 0.818 rs11205166 chr1:152988627 C/G cg00922841 chr1:152955080 SPRR1A -0.4 -6.77 -0.35 5.66e-11 Inflammatory skin disease; LUSC cis rs68170813 0.559 rs75723759 chr7:106962407 A/G cg02696742 chr7:106810147 HBP1 -0.64 -9.46 -0.46 5.6e-19 Coronary artery disease; LUSC trans rs1325195 0.920 rs2793799 chr1:179202209 A/G cg11624085 chr17:8464688 MYH10 -0.41 -6.52 -0.34 2.53e-10 IgE grass sensitization; LUSC cis rs155076 1.000 rs155076 chr13:21870114 A/G cg11317459 chr13:21872234 NA -1.13 -15.8 -0.65 2.23e-42 White matter hyperintensity burden; LUSC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg00750074 chr16:89608354 SPG7 -0.45 -7.75 -0.39 1.11e-13 Multiple myeloma (IgH translocation); LUSC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.23 -0.37 3.4e-12 Alzheimer's disease (late onset); LUSC cis rs7674212 0.510 rs2720468 chr4:104085153 A/G cg16532752 chr4:104119610 CENPE -0.48 -6.78 -0.35 5.31e-11 Type 2 diabetes; LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg24675658 chr1:53192096 ZYG11B 0.82 13.96 0.61 3.32e-35 Monocyte count; LUSC cis rs9467711 0.606 rs9393718 chr6:26407482 G/A cg09904177 chr6:26538194 HMGN4 -0.73 -6.68 -0.34 1e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.07 -0.32 3.51e-9 Alzheimer's disease (late onset); LUSC cis rs9329221 0.648 rs4512422 chr8:10258889 C/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.28 -0.33 1.04e-9 Neuroticism; LUSC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg07741184 chr6:167504864 NA 0.37 6.65 0.34 1.17e-10 Crohn's disease; LUSC cis rs11958404 0.932 rs60504573 chr5:157436786 T/A cg05962755 chr5:157440814 NA 0.53 6.3 0.33 9.34e-10 IgG glycosylation; LUSC cis rs10504073 0.584 rs55838473 chr8:49948281 C/A cg00325661 chr8:49890786 NA 0.7 11.13 0.52 1.1e-24 Blood metabolite ratios; LUSC cis rs6942756 1.000 rs13235749 chr7:128879678 C/G cg02491457 chr7:128862824 NA -0.53 -7.66 -0.39 2.01e-13 White matter hyperintensity burden; LUSC cis rs2274273 0.745 rs56262555 chr14:55561962 C/T cg04306507 chr14:55594613 LGALS3 0.48 10.45 0.5 2.55e-22 Protein biomarker; LUSC cis rs6964587 0.605 rs6956022 chr7:91553199 A/G cg17063962 chr7:91808500 NA -0.56 -9.23 -0.45 3.27e-18 Breast cancer; LUSC cis rs10754283 0.967 rs1320563 chr1:90121032 G/A cg21401794 chr1:90099060 LRRC8C 0.63 8.98 0.44 2.08e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs4654899 0.812 rs7539512 chr1:21410791 A/G cg01072550 chr1:21505969 NA -0.51 -7.8 -0.39 8.21e-14 Superior frontal gyrus grey matter volume; LUSC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg11764359 chr7:65958608 NA -0.63 -9.64 -0.47 1.45e-19 Aortic root size; LUSC cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg15704280 chr7:45808275 SEPT13 0.75 8.36 0.42 1.74e-15 Axial length; LUSC cis rs7084921 0.579 rs11596253 chr10:101849411 C/A cg02250046 chr10:101825185 CPN1 -0.35 -6.2 -0.32 1.63e-9 Bone mineral density; LUSC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg22437258 chr11:111473054 SIK2 0.46 6.05 0.31 3.93e-9 Primary sclerosing cholangitis; LUSC cis rs868036 0.681 rs28626095 chr15:68066729 T/C cg24579218 chr15:68104479 NA -0.34 -6.0 -0.31 5.14e-9 Restless legs syndrome; LUSC trans rs853679 1.000 rs6901575 chr6:28250984 G/A cg06606381 chr12:133084897 FBRSL1 -0.6 -7.09 -0.36 7.99e-12 Depression; LUSC cis rs17685 0.753 rs869806 chr7:75688623 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.47 -0.38 7.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg01802117 chr1:53393560 SCP2 0.36 5.88 0.31 9.95e-9 Monocyte count; LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg06873352 chr17:61820015 STRADA 0.73 13.13 0.58 4.77e-32 Prudent dietary pattern; LUSC cis rs7107174 0.901 rs2512522 chr11:77925855 G/C cg02023728 chr11:77925099 USP35 0.52 7.12 0.36 6.68e-12 Testicular germ cell tumor; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13615036 chr15:91475826 UNC45A;HDDC3 0.76 6.07 0.32 3.44e-9 Cognitive performance; LUSC cis rs7131987 0.650 rs4331146 chr12:29440083 G/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.63 -0.34 1.37e-10 QT interval; LUSC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg13944838 chr5:179740914 GFPT2 -0.67 -10.77 -0.51 2.04e-23 Height; LUSC trans rs1997103 1.000 rs6593238 chr7:55411048 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7264396 0.563 rs59064961 chr20:34307950 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.61 -0.43 2.97e-16 Total cholesterol levels; LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18099408 chr3:52552593 STAB1 -0.42 -7.3 -0.37 2.08e-12 Bipolar disorder; LUSC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg14500267 chr11:67383377 NA 0.31 5.99 0.31 5.3e-9 Mean corpuscular volume; LUSC cis rs9467773 1.000 rs2208331 chr6:26507319 A/G cg09904177 chr6:26538194 HMGN4 0.73 13.27 0.59 1.45e-32 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg05425664 chr17:57184151 TRIM37 -0.56 -8.29 -0.41 2.8e-15 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg14552801 chr7:65878734 NA -0.46 -6.53 -0.34 2.45e-10 Aortic root size; LUSC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.49 7.25 0.37 2.98e-12 Schizophrenia; LUSC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg24154853 chr7:158122151 PTPRN2 0.45 8.8 0.43 7.55e-17 Calcium levels; LUSC cis rs3741151 0.773 rs73544710 chr11:73162273 A/G cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg09367891 chr1:107599246 PRMT6 -0.56 -8.82 -0.43 6.58e-17 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg21724239 chr8:58056113 NA 0.79 8.36 0.42 1.73e-15 Developmental language disorder (linguistic errors); LUSC cis rs12541635 0.966 rs1496182 chr8:107024505 C/T cg10147462 chr8:107024639 NA 0.56 10.17 0.49 2.33e-21 Age of smoking initiation; LUSC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg09455208 chr3:40491958 NA 0.59 10.39 0.49 4.25e-22 Renal cell carcinoma; LUSC trans rs208520 0.507 rs9453585 chr6:66796668 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.21 -25.28 -0.81 1.53e-79 Exhaled nitric oxide output; LUSC cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg03433033 chr1:76189801 ACADM -0.47 -7.06 -0.36 9.68e-12 Daytime sleep phenotypes; LUSC cis rs3125734 0.633 rs10740068 chr10:63982254 A/C cg19640130 chr10:64028056 RTKN2 -0.41 -7.47 -0.38 7.09e-13 Rheumatoid arthritis; LUSC cis rs6700896 0.931 rs59508186 chr1:66107881 C/A cg04111102 chr1:66153794 NA 0.3 6.48 0.33 3.2e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs877282 1.000 rs12775643 chr10:773242 G/A cg13042288 chr15:90349979 ANPEP -0.48 -6.91 -0.35 2.46e-11 Uric acid levels; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg02927485 chr7:97601469 MGC72080 0.45 5.97 0.31 6.03e-9 Neuroticism; LUSC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg01283332 chr5:1856932 NA -0.33 -6.15 -0.32 2.21e-9 Cardiovascular disease risk factors; LUSC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg26314531 chr2:26401878 FAM59B -0.67 -9.3 -0.45 1.92e-18 Gut microbiome composition (summer); LUSC cis rs2295359 0.824 rs12060309 chr1:67604219 T/C cg17031739 chr1:67600172 NA 0.49 7.59 0.38 3.33e-13 Psoriasis; LUSC trans rs2727020 0.595 rs10839281 chr11:49483373 A/C cg03929089 chr4:120376271 NA -0.99 -17.59 -0.69 1.74e-49 Coronary artery disease; LUSC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg06637938 chr14:75390232 RPS6KL1 0.86 16.13 0.66 1.06e-43 Caffeine consumption; LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg11494091 chr17:61959527 GH2 0.63 13.44 0.59 3.14e-33 Prudent dietary pattern; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03934478 chr11:495069 RNH1 0.85 9.72 0.47 7.65e-20 Body mass index; LUSC cis rs9682041 0.569 rs11914970 chr3:170112307 T/G cg11886554 chr3:170076028 SKIL 0.72 9.85 0.47 3.02e-20 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4268898 0.760 rs55863105 chr2:24570695 C/T cg06627628 chr2:24431161 ITSN2 0.57 8.07 0.4 1.24e-14 Asthma; LUSC cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs9942416 0.533 rs12109685 chr5:75024066 A/G cg19683494 chr5:74908142 NA 0.5 6.88 0.35 2.94e-11 Age-related disease endophenotypes; LUSC cis rs7193541 0.662 rs8058133 chr16:74657485 A/T cg01733217 chr16:74700730 RFWD3 1.0 21.85 0.77 2.39e-66 Multiple myeloma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25235159 chr11:47600280 KBTBD4;NDUFS3 -0.45 -6.73 -0.35 7.61e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1595825 1.000 rs73058832 chr2:198873214 G/T cg00982548 chr2:198649783 BOLL -0.5 -6.23 -0.32 1.38e-9 Ulcerative colitis; LUSC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.7 -0.39 1.58e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9325144 0.723 rs11169518 chr12:39177237 C/A cg26384229 chr12:38710491 ALG10B -0.6 -9.3 -0.45 1.91e-18 Morning vs. evening chronotype; LUSC cis rs9419702 0.568 rs7920966 chr10:133555185 G/T cg04492858 chr10:133558786 NA 0.36 6.33 0.33 8.01e-10 Survival in rectal cancer; LUSC trans rs4800353 0.929 rs7238695 chr18:19609624 G/T cg01841828 chr16:69166849 CHTF8;CIRH1A -0.58 -6.04 -0.31 4.02e-9 Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg13535736 chr9:111863775 C9orf5 -0.4 -6.6 -0.34 1.59e-10 Menarche (age at onset); LUSC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg09365446 chr1:150670422 GOLPH3L 0.51 7.5 0.38 5.68e-13 Melanoma; LUSC cis rs4319547 0.695 rs6488958 chr12:122880704 A/G cg23029597 chr12:123009494 RSRC2 -0.73 -9.14 -0.45 6.05e-18 Body mass index; LUSC cis rs2637266 1.000 rs35991266 chr10:78378733 A/G cg18941641 chr10:78392320 NA 0.38 6.94 0.36 2.04e-11 Pulmonary function; LUSC cis rs13242816 1.000 rs7809755 chr7:116110732 C/T cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs7582180 0.764 rs4635546 chr2:100921125 G/A cg12002119 chr2:101014098 CHST10 0.36 6.09 0.32 3.15e-9 Intelligence (multi-trait analysis); LUSC cis rs478304 0.654 rs7947604 chr11:65442059 G/C cg27068330 chr11:65405492 SIPA1 -0.76 -10.72 -0.51 3.02e-23 Acne (severe); LUSC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg23283495 chr1:209979779 IRF6 0.64 9.36 0.46 1.21e-18 Cleft lip with or without cleft palate; LUSC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg13114125 chr14:105738426 BRF1 -0.91 -15.96 -0.66 5.17e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg15448220 chr1:150897856 SETDB1 0.42 6.12 0.32 2.6e-9 Melanoma; LUSC cis rs2274273 0.624 rs10132453 chr14:55840851 C/T cg04306507 chr14:55594613 LGALS3 0.49 9.94 0.48 1.47e-20 Protein biomarker; LUSC cis rs11997175 0.716 rs7460818 chr8:33816362 A/G ch.8.33884649F chr8:33765107 NA 0.53 8.17 0.41 6.33e-15 Body mass index; LUSC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg05890377 chr2:74357713 NA 0.72 13.65 0.6 4.97e-34 Gestational age at birth (maternal effect); LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg18404041 chr3:52824283 ITIH1 -0.56 -10.62 -0.5 7.08e-23 Bipolar disorder; LUSC cis rs2262909 0.962 rs73019844 chr19:22249925 T/C cg11619707 chr19:22235551 ZNF257 0.39 5.83 0.3 1.29e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9311676 0.632 rs56281646 chr3:58424917 G/A cg13750441 chr3:58318267 PXK 0.35 6.73 0.35 7.53e-11 Systemic lupus erythematosus; LUSC cis rs9311676 0.656 rs6445973 chr3:58336595 G/T cg26110898 chr3:58419937 PDHB -0.39 -6.11 -0.32 2.73e-9 Systemic lupus erythematosus; LUSC cis rs1577917 1.000 rs68171315 chr6:86707400 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.94 -0.35 2.06e-11 Response to antipsychotic treatment; LUSC trans rs12043259 0.730 rs7539437 chr1:204795888 G/T cg05134015 chr14:36973365 SFTA3 -0.5 -6.04 -0.31 4.05e-9 Addiction; LUSC cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg26384229 chr12:38710491 ALG10B 0.92 15.65 0.65 8.39e-42 Bladder cancer; LUSC trans rs2204008 0.840 rs7957966 chr12:37953629 A/G cg06521331 chr12:34319734 NA 0.4 6.42 0.33 4.59e-10 Bladder cancer; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.69 0.43 1.65e-16 Prudent dietary pattern; LUSC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.72 0.51 3.04e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs950169 0.580 rs62021208 chr15:85196244 G/A cg17173187 chr15:85201210 NMB 0.49 9.48 0.46 4.73e-19 Schizophrenia; LUSC cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg15556689 chr8:8085844 FLJ10661 -0.6 -10.25 -0.49 1.28e-21 Mood instability; LUSC cis rs16912285 0.688 rs7128680 chr11:24338796 C/T ch.11.24196551F chr11:24239977 NA 0.85 8.18 0.41 6.17e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs11603020 0.950 rs28362948 chr11:57369013 A/C cg23127183 chr11:57508653 C11orf31 -0.46 -6.36 -0.33 6.65e-10 Blood protein levels; LUSC trans rs7980799 0.682 rs1447873 chr12:33615236 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.35 -0.33 7.23e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs7481584 0.624 rs421196 chr11:3048582 T/G cg08508325 chr11:3079039 CARS 0.36 8.15 0.41 7.41e-15 Calcium levels; LUSC cis rs6577655 0.547 rs7841171 chr8:135591699 G/A cg17885191 chr8:135476712 NA 0.58 7.55 0.38 4.15e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs367943 0.712 rs13359330 chr5:112708529 T/C cg12552261 chr5:112820674 MCC 0.35 5.73 0.3 2.23e-8 Type 2 diabetes; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18595196 chr3:52726726 GNL3;SNORD69 -0.29 -5.65 -0.3 3.46e-8 Bipolar disorder; LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg00684032 chr4:1343700 KIAA1530 -0.36 -6.32 -0.33 8.46e-10 Obesity-related traits; LUSC cis rs9517320 0.515 rs1107379 chr13:99198921 C/T cg07423050 chr13:99094983 FARP1 -0.53 -9.76 -0.47 5.98e-20 Longevity; LUSC cis rs10979 0.597 rs9403516 chr6:143908139 A/T cg25407410 chr6:143891975 LOC285740 0.61 7.72 0.39 1.34e-13 Hypospadias; LUSC cis rs11166629 0.637 rs1899432 chr8:135576255 C/T cg27224718 chr8:135614730 ZFAT 0.54 7.84 0.39 5.92e-14 Smoking quantity; LUSC cis rs1524927 0.933 rs12704874 chr7:96340744 A/G cg03808172 chr7:96339361 SHFM1 0.43 6.66 0.34 1.12e-10 Total body bone mineral density; LUSC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs62103177 0.525 rs10438902 chr18:77745640 A/G cg14227996 chr4:17616232 MED28 -0.6 -6.67 -0.34 1.06e-10 Opioid sensitivity; LUSC cis rs7598759 0.712 rs997400 chr2:232332847 C/T cg19187155 chr2:232395269 NMUR1 0.49 7.2 0.37 3.96e-12 Noise-induced hearing loss; LUSC cis rs9902453 0.868 rs9902340 chr17:28476458 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -9.07 -0.44 1.08e-17 Coffee consumption (cups per day); LUSC cis rs7615316 1.000 rs9824893 chr3:142341152 A/T cg16271453 chr3:142027066 XRN1 -0.36 -6.2 -0.32 1.64e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs71403859 0.730 rs35390364 chr16:71740049 A/G cg08717414 chr16:71523259 ZNF19 -0.65 -7.11 -0.36 7.27e-12 Post bronchodilator FEV1; LUSC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg06494592 chr3:125709126 NA -0.5 -5.79 -0.3 1.64e-8 Blood pressure (smoking interaction); LUSC cis rs6546886 0.957 rs11886928 chr2:74258529 T/G cg14702570 chr2:74259524 NA -0.31 -5.91 -0.31 8.36e-9 Dialysis-related mortality; LUSC cis rs654950 0.875 rs881719 chr1:41991427 C/T cg06885757 chr1:42089581 HIVEP3 -0.38 -7.41 -0.38 1.04e-12 Airway imaging phenotypes; LUSC cis rs9467773 1.000 rs9393728 chr6:26509330 C/G cg05738196 chr6:26577821 NA 0.81 15.2 0.64 4.92e-40 Intelligence (multi-trait analysis); LUSC cis rs4499344 0.730 rs259285 chr19:33164697 T/C cg22980127 chr19:33182716 NUDT19 -0.42 -6.3 -0.33 9.55e-10 Mean platelet volume; LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg08280861 chr8:58055591 NA 0.58 7.29 0.37 2.22e-12 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg06784218 chr1:46089804 CCDC17 -0.57 -11.34 -0.53 1.97e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2439831 1.000 rs2444250 chr15:43785051 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs4776059 1.000 rs17614559 chr15:52878719 G/A cg22715398 chr15:52968154 KIAA1370 -0.66 -9.41 -0.46 8.34e-19 Schizophrenia; LUSC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs12410462 0.581 rs111356515 chr1:227537236 C/G cg10327440 chr1:227177885 CDC42BPA -0.66 -6.52 -0.34 2.61e-10 Major depressive disorder; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg11060661 chr22:24314208 DDT;DDTL 0.47 7.58 0.38 3.55e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs921968 0.565 rs6436072 chr2:219598095 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -9.99 -0.48 1.02e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg16928487 chr17:17741425 SREBF1 -0.43 -8.55 -0.42 4.5e-16 Total body bone mineral density; LUSC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.65 0.39 2.21e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg11645453 chr3:52864694 ITIH4 0.29 6.84 0.35 3.86e-11 Electroencephalogram traits; LUSC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.96 0.44 2.3e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.6 -9.67 -0.47 1.18e-19 Prudent dietary pattern; LUSC cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.16 0.68 9.42e-48 Chronic sinus infection; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.72 11.55 0.53 3.46e-26 Prudent dietary pattern; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02938130 chr5:150460100 TNIP1 0.46 6.14 0.32 2.35e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.09 0.48 4.41e-21 Bladder cancer; LUSC cis rs7236492 0.683 rs79747802 chr18:77198964 C/T cg15644404 chr18:77186268 NFATC1 -0.68 -7.62 -0.38 2.63e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7712401 0.601 rs374403 chr5:122341713 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.25 -0.45 2.68e-18 Mean platelet volume; LUSC cis rs10751667 0.714 rs7395879 chr11:963855 G/C ch.11.42038R chr11:967971 AP2A2 0.44 6.6 0.34 1.63e-10 Alzheimer's disease (late onset); LUSC cis rs765787 0.530 rs28756676 chr15:45540360 G/A cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.04e-16 Uric acid levels; LUSC cis rs72781680 0.716 rs72788206 chr2:24084989 T/C cg08917208 chr2:24149416 ATAD2B 0.6 7.04 0.36 1.08e-11 Lymphocyte counts; LUSC trans rs7824557 0.583 rs2736306 chr8:11239762 A/T cg06636001 chr8:8085503 FLJ10661 0.49 7.09 0.36 7.95e-12 Retinal vascular caliber; LUSC cis rs3820928 0.874 rs3752896 chr2:227886925 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.69 -0.39 1.66e-13 Pulmonary function; LUSC trans rs11722228 0.549 rs73212830 chr4:10078759 A/T cg26043149 chr18:55253948 FECH 0.99 14.7 0.63 4.58e-38 Gout;Urate levels;Serum uric acid levels; LUSC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg08392591 chr16:89556376 ANKRD11 0.44 6.82 0.35 4.38e-11 Multiple myeloma (IgH translocation); LUSC cis rs7615952 0.866 rs1976459 chr3:125647486 A/T cg05084668 chr3:125655381 ALG1L -0.79 -11.93 -0.55 1.47e-27 Blood pressure (smoking interaction); LUSC cis rs9393692 0.645 rs6939048 chr6:26327953 G/A cg00631329 chr6:26305371 NA -0.56 -10.8 -0.51 1.57e-23 Educational attainment; LUSC cis rs36093844 0.848 rs2084079 chr11:85590436 C/A cg25872744 chr11:85566296 CCDC83 -0.42 -6.2 -0.32 1.64e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs12579753 0.833 rs1922566 chr12:82135030 T/C cg07988820 chr12:82153109 PPFIA2 -0.45 -6.42 -0.33 4.69e-10 Resting heart rate; LUSC cis rs7799006 0.755 rs12534131 chr7:2294123 C/T cg12823233 chr7:2316876 SNX8 -0.45 -7.71 -0.39 1.43e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg03929089 chr4:120376271 NA 0.69 7.78 0.39 9.14e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs2354432 0.505 rs4424556 chr1:146863973 G/C cg25205988 chr1:146714368 CHD1L 0.86 7.57 0.38 3.78e-13 Mitochondrial DNA levels; LUSC cis rs3008870 0.583 rs3008892 chr1:67373558 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.93 13.96 0.61 3.41e-35 Lymphocyte percentage of white cells; LUSC cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.74 -0.3 2.08e-8 Bipolar disorder; LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.18 0.52 7.07e-25 Menopause (age at onset); LUSC cis rs7937682 0.632 rs11214015 chr11:111719417 A/T cg09085632 chr11:111637200 PPP2R1B -0.94 -12.52 -0.57 9.36e-30 Primary sclerosing cholangitis; LUSC cis rs7769051 1.000 rs5006218 chr6:133126220 T/G cg22852734 chr6:133119734 C6orf192 1.17 14.05 0.61 1.48e-35 Type 2 diabetes nephropathy; LUSC cis rs765787 0.530 rs2433229 chr15:45515235 C/A cg24006582 chr15:45444508 DUOX1 -0.62 -9.1 -0.45 8.07e-18 Uric acid levels; LUSC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg13628971 chr7:2884303 GNA12 0.46 6.57 0.34 1.91e-10 Height; LUSC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg21918786 chr6:109611834 NA -0.4 -6.9 -0.35 2.61e-11 Reticulocyte fraction of red cells; LUSC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs3540 0.597 rs10152221 chr15:91047664 A/G cg22089800 chr15:90895588 ZNF774 -0.64 -9.68 -0.47 1.06e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg14584255 chr6:163149320 PACRG;PARK2 -0.34 -6.52 -0.34 2.66e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs75804782 0.641 rs2340870 chr2:239356026 C/T cg18131467 chr2:239335373 ASB1 -0.72 -6.6 -0.34 1.63e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg01238044 chr22:24384105 GSTT1 -0.71 -11.3 -0.53 2.61e-25 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg08477640 chr19:41863820 B9D2 -0.53 -8.11 -0.41 9.52e-15 Colorectal cancer; LUSC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg20607287 chr7:12443886 VWDE -0.57 -6.03 -0.31 4.43e-9 Coronary artery disease; LUSC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg19230755 chr7:65878503 NA -0.43 -5.96 -0.31 6.34e-9 Aortic root size; LUSC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg05234568 chr11:5960015 NA -0.55 -8.71 -0.43 1.43e-16 DNA methylation (variation); LUSC cis rs9467773 1.000 rs3736781 chr6:26505362 G/A cg05738196 chr6:26577821 NA 0.81 15.2 0.64 4.95e-40 Intelligence (multi-trait analysis); LUSC cis rs7659604 0.935 rs73844280 chr4:122664687 G/A cg20573242 chr4:122745356 CCNA2 0.45 6.89 0.35 2.72e-11 Type 2 diabetes; LUSC cis rs752010 0.806 rs10890148 chr1:42091517 T/C cg06885757 chr1:42089581 HIVEP3 0.49 10.05 0.48 6.05e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.06e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg12432903 chr7:1882776 MAD1L1 -0.39 -6.23 -0.32 1.42e-9 Bipolar disorder and schizophrenia; LUSC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg13939156 chr17:80058883 NA -0.33 -6.6 -0.34 1.65e-10 Life satisfaction; LUSC cis rs7072216 0.587 rs3814141 chr10:100171028 G/A cg26618903 chr10:100175079 PYROXD2 -0.43 -7.15 -0.36 5.46e-12 Metabolite levels; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.52 7.81 0.39 7.58e-14 Lymphocyte counts; LUSC cis rs243505 0.660 rs3807451 chr7:148538622 T/C cg09806900 chr7:148480153 CUL1 0.49 6.46 0.33 3.78e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs950169 0.580 rs35516100 chr15:85195430 C/T cg17173187 chr15:85201210 NMB 0.49 9.48 0.46 4.73e-19 Schizophrenia; LUSC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.79 -0.3 1.65e-8 Vitiligo; LUSC cis rs7712401 0.562 rs30062 chr5:122296376 C/G cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs7914558 1.000 rs10786740 chr10:104935593 G/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.84 -0.35 3.89e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.06e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7617480 0.648 rs6806356 chr3:48727636 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.59 8.87 0.44 4.5e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1178127 0.580 rs1178173 chr7:18795959 A/C cg02370815 chr7:18831390 HDAC9 -0.39 -5.82 -0.3 1.34e-8 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); LUSC cis rs748404 0.697 rs498227 chr15:43573052 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.56 8.84 0.44 5.75e-17 Lung cancer; LUSC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg09034736 chr1:150693464 HORMAD1 0.47 6.48 0.33 3.35e-10 Urate levels; LUSC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg09365446 chr1:150670422 GOLPH3L 0.45 6.61 0.34 1.52e-10 Melanoma; LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg10802521 chr3:52805072 NEK4 -0.53 -8.05 -0.4 1.48e-14 Bipolar disorder; LUSC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.59e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg03351412 chr1:154909251 PMVK 0.56 8.9 0.44 3.73e-17 Prostate cancer; LUSC trans rs2739330 0.587 rs4820571 chr22:24242973 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.51 -8.19 -0.41 5.53e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7428496 0.528 rs4256152 chr3:142219542 A/G cg16271453 chr3:142027066 XRN1 0.5 8.96 0.44 2.34e-17 Mean corpuscular hemoglobin; LUSC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg03517284 chr6:25882590 NA -0.53 -8.77 -0.43 9.16e-17 Intelligence (multi-trait analysis); LUSC cis rs11785400 0.793 rs1137521 chr8:143739162 C/T cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg00945038 chr17:61921165 SMARCD2 0.53 9.26 0.45 2.6e-18 Prudent dietary pattern; LUSC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg17178900 chr1:205818956 PM20D1 -0.41 -5.69 -0.3 2.72e-8 Parkinson's disease; LUSC cis rs11148252 0.553 rs9536219 chr13:53227301 C/T cg02158880 chr13:53174818 NA 0.57 9.69 0.47 1.02e-19 Lewy body disease; LUSC cis rs1784581 0.588 rs1789988 chr6:162408472 C/T cg17173639 chr6:162384350 PARK2 -0.58 -9.94 -0.48 1.42e-20 Itch intensity from mosquito bite; LUSC trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.27 0.37 2.49e-12 Neuroticism; LUSC cis rs34779708 0.931 rs17583009 chr10:35320915 T/C cg04310649 chr10:35416472 CREM -0.4 -6.04 -0.31 4.2e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg11965913 chr1:205819406 PM20D1 1.05 27.58 0.83 4.35e-88 Menarche (age at onset); LUSC trans rs7824557 0.628 rs11782706 chr8:11186215 A/C cg06636001 chr8:8085503 FLJ10661 0.42 6.13 0.32 2.43e-9 Retinal vascular caliber; LUSC cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg22117172 chr7:91764530 CYP51A1 0.32 5.68 0.3 2.9e-8 Breast cancer; LUSC cis rs17253792 0.822 rs78323463 chr14:56045451 T/G cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC trans rs9329221 0.506 rs17689674 chr8:9981854 C/A cg15556689 chr8:8085844 FLJ10661 0.55 8.28 0.41 3.03e-15 Neuroticism; LUSC cis rs1322512 0.917 rs2758803 chr6:152955858 G/A cg27316956 chr6:152958899 SYNE1 -0.36 -6.07 -0.32 3.55e-9 Tonometry; LUSC cis rs7759001 0.857 rs9468111 chr6:27355083 T/A cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs12620999 0.941 rs62183342 chr2:237979140 C/A cg23555395 chr2:238036564 NA 0.45 7.87 0.4 5.05e-14 Systemic lupus erythematosus; LUSC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg03806693 chr22:41940476 POLR3H -0.93 -13.27 -0.59 1.43e-32 Vitiligo; LUSC cis rs13064411 0.696 rs35860985 chr3:113209828 C/T cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg03146154 chr1:46216737 IPP -0.57 -8.28 -0.41 2.94e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs17401966 0.931 rs746881 chr1:10346810 C/T cg19773385 chr1:10388646 KIF1B 0.57 9.95 0.48 1.35e-20 Hepatocellular carcinoma; LUSC cis rs9325144 0.555 rs1813392 chr12:38692203 C/T cg13010199 chr12:38710504 ALG10B -0.48 -7.42 -0.38 1.01e-12 Morning vs. evening chronotype; LUSC cis rs12190007 0.517 rs3006210 chr6:169828915 C/T ch.6.169577133F chr6:169835210 NA -0.4 -5.96 -0.31 6.54e-9 Obesity-related traits; LUSC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs12541635 0.677 rs1496183 chr8:107024445 C/T cg10147462 chr8:107024639 NA 0.68 14.15 0.61 5.93e-36 Age of smoking initiation; LUSC cis rs9650657 0.571 rs4240673 chr8:10787612 T/C cg21775007 chr8:11205619 TDH -0.49 -7.01 -0.36 1.3e-11 Neuroticism; LUSC cis rs4746822 0.954 rs10998647 chr10:70977308 T/G cg14418922 chr10:70824840 NA -0.38 -6.1 -0.32 2.85e-9 Glycemic traits (pregnancy); LUSC cis rs73206853 0.686 rs56339227 chr12:111164963 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.52 0.38 5.1e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg08219700 chr8:58056026 NA 0.68 7.92 0.4 3.63e-14 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs7310237 chr12:34483435 G/A cg26384229 chr12:38710491 ALG10B 0.79 13.51 0.59 1.72e-33 Morning vs. evening chronotype; LUSC cis rs7177699 0.567 rs67745769 chr15:79124832 G/A cg00540400 chr15:79124168 NA -0.47 -8.17 -0.41 6.66e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg26513180 chr16:89883248 FANCA -0.53 -7.89 -0.4 4.28e-14 Vitiligo; LUSC cis rs1348850 0.872 rs7559521 chr2:178452328 A/G cg22681709 chr2:178499509 PDE11A 0.48 8.7 0.43 1.58e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9581857 0.615 rs3759435 chr13:27996813 T/G cg22138327 chr13:27999177 GTF3A 0.85 10.8 0.51 1.61e-23 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19608455 chr18:48086580 MAPK4 -0.39 -5.97 -0.31 6.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg18190219 chr22:46762943 CELSR1 -0.48 -6.02 -0.31 4.53e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg15839431 chr19:19639596 YJEFN3 -0.63 -7.11 -0.36 7.15e-12 Bipolar disorder; LUSC cis rs709400 0.628 rs72708854 chr14:103864885 T/C cg24130564 chr14:104152367 KLC1 -0.41 -5.83 -0.3 1.29e-8 Body mass index; LUSC trans rs10802346 0.545 rs10924545 chr1:246364592 C/T cg22732515 chr19:44031385 ETHE1 -0.62 -10.44 -0.5 2.86e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg10802521 chr3:52805072 NEK4 -0.54 -8.71 -0.43 1.43e-16 Bipolar disorder; LUSC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg11062466 chr8:58055876 NA 0.71 8.5 0.42 6.29e-16 Developmental language disorder (linguistic errors); LUSC cis rs2387326 0.717 rs11016102 chr10:129945154 A/G cg16087940 chr10:129947807 NA -0.4 -6.09 -0.32 3.03e-9 Select biomarker traits; LUSC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg04025307 chr7:1156635 C7orf50 0.44 6.06 0.31 3.75e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7202877 0.706 rs4993971 chr16:75411634 C/G cg04384234 chr16:75411784 CFDP1 0.62 8.84 0.44 5.73e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg18099408 chr3:52552593 STAB1 -0.41 -7.1 -0.36 7.53e-12 Bipolar disorder; LUSC cis rs7267979 0.586 rs1007707 chr20:25190598 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.73 0.57 1.59e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4953318 0.619 rs35744969 chr2:46353140 C/A cg12428440 chr2:46370979 PRKCE 0.49 8.16 0.41 6.98e-15 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs754466 0.606 rs11002309 chr10:79594931 C/T cg17075019 chr10:79541650 NA -0.78 -12.26 -0.56 8.46e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg06784218 chr1:46089804 CCDC17 -0.58 -11.64 -0.54 1.62e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4906332 1.000 rs2065015 chr14:103904061 G/T cg04998671 chr14:104000505 TRMT61A 0.46 7.09 0.36 8.13e-12 Coronary artery disease; LUSC cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg18196295 chr10:418757 DIP2C 0.49 8.05 0.4 1.47e-14 Psychosis in Alzheimer's disease; LUSC cis rs7799006 0.722 rs33981648 chr7:2288669 T/C cg02951883 chr7:2050386 MAD1L1 -0.38 -6.27 -0.32 1.15e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.21 0.56 1.29e-28 Motion sickness; LUSC cis rs1215050 0.791 rs983187 chr4:98816350 A/T cg05340658 chr4:99064831 C4orf37 0.43 6.87 0.35 3.23e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1729951 0.575 rs361244 chr3:136697506 C/T cg21827317 chr3:136751795 NA 0.38 6.9 0.35 2.61e-11 Neuroticism; LUSC cis rs4343996 0.558 rs7794534 chr7:3416396 T/C cg21248987 chr7:3385318 SDK1 0.36 6.15 0.32 2.18e-9 Motion sickness; LUSC cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg00339695 chr16:24857497 SLC5A11 -0.41 -7.06 -0.36 9.49e-12 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.794 rs116409325 chr17:41445460 C/A cg25072359 chr17:41440525 NA 0.64 9.29 0.45 1.99e-18 Menopause (age at onset); LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18758796 chr5:131593413 PDLIM4 0.53 9.16 0.45 5.21e-18 Acylcarnitine levels; LUSC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg22920501 chr2:26401640 FAM59B 0.74 10.27 0.49 1.07e-21 Gut microbiome composition (summer); LUSC cis rs6456156 0.586 rs2001115 chr6:167486218 A/C cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs2281845 0.507 rs11589642 chr1:201100748 A/G cg06714761 chr1:201096289 NA -0.43 -7.71 -0.39 1.42e-13 Permanent tooth development; LUSC cis rs1801251 0.963 rs283481 chr2:233648091 A/G cg08000102 chr2:233561755 GIGYF2 0.75 11.78 0.54 4.88e-27 Coronary artery disease; LUSC cis rs7512552 0.839 rs1260386 chr1:150369622 G/T cg15654264 chr1:150340011 RPRD2 0.61 10.09 0.48 4.38e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs28374715 0.681 rs28728213 chr15:41653602 T/A cg18705301 chr15:41695430 NDUFAF1 -0.96 -20.14 -0.74 1.32e-59 Ulcerative colitis; LUSC cis rs478304 0.817 rs524475 chr11:65518065 T/A cg27068330 chr11:65405492 SIPA1 0.62 9.33 0.45 1.54e-18 Acne (severe); LUSC cis rs9611519 1.000 rs2273085 chr22:41615376 C/T cg03806693 chr22:41940476 POLR3H -0.5 -6.88 -0.35 2.9100000000000002e-11 Neuroticism; LUSC trans rs8073060 0.544 rs17550716 chr17:33893208 A/G cg19694781 chr19:47549865 TMEM160 1.13 18.22 0.71 5.4e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg15790184 chr11:494944 RNH1 0.49 7.53 0.38 4.71e-13 Systemic lupus erythematosus; LUSC cis rs7727544 0.606 rs17622208 chr5:131717050 G/A cg12564285 chr5:131593104 PDLIM4 0.35 6.28 0.33 1.05e-9 Blood metabolite levels; LUSC cis rs35094601 0.731 rs62161708 chr2:139230824 A/G cg10095539 chr2:139258744 SPOPL 0.26 6.03 0.31 4.37e-9 Schizophrenia; LUSC cis rs6121246 0.529 rs6060296 chr20:30198480 T/C cg18721089 chr20:30220636 NA -0.41 -6.57 -0.34 1.93e-10 Mean corpuscular hemoglobin; LUSC cis rs11168618 0.567 rs12372687 chr12:48811799 G/T cg24011408 chr12:48396354 COL2A1 0.42 6.64 0.34 1.3e-10 Adiponectin levels; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg21782813 chr7:2030301 MAD1L1 -0.36 -5.94 -0.31 7.13e-9 Bipolar disorder and schizophrenia; LUSC cis rs983392 0.709 rs7939882 chr11:59973929 A/C cg20284999 chr11:59952153 MS4A6A -0.37 -6.21 -0.32 1.6e-9 Alzheimer's disease (late onset); LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg03395511 chr6:291903 DUSP22 0.71 11.96 0.55 1.12e-27 Menopause (age at onset); LUSC cis rs9487051 0.768 rs351729 chr6:109511668 T/C cg01475377 chr6:109611718 NA 0.36 6.1 0.32 2.88e-9 Reticulocyte fraction of red cells; LUSC cis rs4363385 0.747 rs4255332 chr1:152958745 G/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.78 -0.39 9.33e-14 Inflammatory skin disease; LUSC cis rs10740039 0.842 rs10761539 chr10:62409491 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.85 -0.35 3.61e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs34421088 0.532 rs1545073 chr8:11167700 C/T cg27411982 chr8:10470053 RP1L1 0.38 6.04 0.31 4.13e-9 Neuroticism; LUSC cis rs1790761 0.802 rs2276118 chr11:67288594 A/G cg24690094 chr11:67383802 NA -0.31 -5.99 -0.31 5.55e-9 Mean corpuscular volume; LUSC cis rs11148252 0.634 rs4941727 chr13:52721067 A/G cg00495681 chr13:53174319 NA -0.39 -6.07 -0.32 3.4e-9 Lewy body disease; LUSC cis rs1355223 0.573 rs286865 chr11:34719916 A/G cg11058730 chr11:34937778 PDHX;APIP 0.41 5.75 0.3 2.02e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg13206674 chr6:150067644 NUP43 0.61 9.65 0.47 1.39e-19 Lung cancer; LUSC cis rs12534701 1.000 rs13232266 chr7:154681363 A/T cg24255201 chr7:154684926 DPP6 0.37 5.72 0.3 2.31e-8 Colorectal cancer (diet interaction); LUSC cis rs7829975 0.606 rs11776838 chr8:8794801 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.74 -0.43 1.15e-16 Mood instability; LUSC cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg24110177 chr3:50126178 RBM5 0.51 7.98 0.4 2.44e-14 Menarche (age at onset); LUSC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg15704280 chr7:45808275 SEPT13 -1.08 -20.73 -0.75 6.03e-62 Coronary artery disease; LUSC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18404041 chr3:52824283 ITIH1 -0.49 -9.01 -0.44 1.57e-17 Bipolar disorder; LUSC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg04166393 chr7:2884313 GNA12 0.44 5.74 0.3 2.09e-8 Height; LUSC cis rs12594515 1.000 rs35182335 chr15:45995184 C/G cg19682013 chr15:45996608 NA 0.39 5.8 0.3 1.51e-8 Waist circumference;Weight; LUSC cis rs7131987 0.903 rs7970390 chr12:29398655 A/G cg09582351 chr12:29534625 ERGIC2 -0.32 -6.72 -0.35 7.71e-11 QT interval; LUSC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg04053776 chr11:6947353 ZNF215 0.55 7.89 0.4 4.23e-14 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg16586182 chr3:47516702 SCAP 0.56 8.76 0.43 1.02e-16 Colorectal cancer; LUSC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg24531977 chr5:56204891 C5orf35 -0.86 -14.25 -0.61 2.6e-36 Initial pursuit acceleration; LUSC cis rs701145 0.585 rs357477 chr3:153892717 A/G cg10247383 chr3:153839028 SGEF -0.65 -5.86 -0.31 1.11e-8 Coronary artery disease; LUSC cis rs7527798 0.592 rs12119104 chr1:207861207 A/G cg09232269 chr1:207846808 CR1L -0.31 -6.46 -0.33 3.73e-10 Erythrocyte sedimentation rate; LUSC cis rs1997103 1.000 rs9649851 chr7:55398692 C/A cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs11039100 0.850 rs34037040 chr11:5834673 G/A cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg16049864 chr8:95962084 TP53INP1 -0.49 -8.12 -0.41 8.97e-15 Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19889152 chr6:33588278 ITPR3 -0.46 -6.92 -0.35 2.28e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg05347473 chr6:146136440 FBXO30 -0.39 -6.65 -0.34 1.2e-10 Lobe attachment (rater-scored or self-reported); LUSC trans rs2797160 1.000 rs1777226 chr6:126017691 C/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.95 0.36 1.88e-11 Endometrial cancer; LUSC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg02269571 chr22:50332266 NA 0.54 8.11 0.41 9.49e-15 Schizophrenia; LUSC cis rs6541297 0.941 rs6541294 chr1:230278826 A/G cg05784532 chr1:230284198 GALNT2 0.49 7.39 0.38 1.16e-12 Coronary artery disease; LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg22166914 chr1:53195759 ZYG11B 0.51 8.19 0.41 5.63e-15 Monocyte count; LUSC cis rs11048434 0.736 rs11048337 chr12:9121330 C/A cg13575925 chr12:9217583 LOC144571 0.35 6.66 0.34 1.13e-10 Sjögren's syndrome; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg08200582 chr11:442649 ANO9 -0.5 -5.71 -0.3 2.55e-8 Body mass index; LUSC cis rs2425143 1.000 rs7273668 chr20:34442731 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -6.09 -0.32 3.08e-9 Blood protein levels; LUSC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4803468 1.000 rs284652 chr19:41928652 C/T cg09537434 chr19:41945824 ATP5SL -0.92 -16.09 -0.66 1.58e-43 Height; LUSC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg19812747 chr11:111475976 SIK2 -0.55 -8.24 -0.41 4.08e-15 Primary sclerosing cholangitis; LUSC trans rs11098499 0.954 rs12505469 chr4:120249585 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.28 0.32 1.04e-9 Corneal astigmatism; LUSC trans rs9944715 0.954 rs11082514 chr18:43770207 C/T cg01718231 chr17:29326311 RNF135 -0.51 -7.25 -0.37 2.91e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs1784581 0.761 rs7741581 chr6:162435250 C/T cg17173639 chr6:162384350 PARK2 0.65 11.46 0.53 7.1e-26 Itch intensity from mosquito bite; LUSC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 7.69 0.39 1.71e-13 Schizophrenia; LUSC cis rs2835872 0.828 rs857980 chr21:38995142 G/A cg20424643 chr21:39039972 KCNJ6 -0.38 -5.94 -0.31 7.07e-9 Electroencephalographic traits in alcoholism; LUSC cis rs11690935 0.549 rs2129475 chr2:172916772 A/G cg13550731 chr2:172543902 DYNC1I2 0.55 8.55 0.42 4.62e-16 Schizophrenia; LUSC trans rs11098499 0.863 rs3822194 chr4:120471648 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.88 0.4 4.72e-14 Corneal astigmatism; LUSC cis rs3771570 1.000 rs3771570 chr2:242382864 C/T cg21155796 chr2:242212141 HDLBP 0.6 6.54 0.34 2.28e-10 Prostate cancer; LUSC cis rs3774830 0.748 rs58854245 chr4:5466134 G/A cg26943120 chr4:5472116 STK32B 0.29 5.76 0.3 1.93e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.31 -0.45 1.8e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10089 1.000 rs6595806 chr5:127499764 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 12.13 0.55 2.55e-28 Ileal carcinoids; LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs2953174 0.938 rs2975767 chr2:241538229 A/G cg07929629 chr2:241523174 NA 0.44 5.94 0.31 7.14e-9 Bipolar disorder; LUSC cis rs7824557 0.767 rs7003241 chr8:11169075 A/G cg27411982 chr8:10470053 RP1L1 0.38 5.91 0.31 8.47e-9 Retinal vascular caliber; LUSC cis rs7605378 1.000 rs769954 chr2:200692159 C/G cg17644776 chr2:200775616 C2orf69 -0.35 -5.66 -0.3 3.25e-8 Osteoporosis; LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg08067268 chr2:26466485 HADHB;HADHA -0.57 -8.43 -0.42 1.05e-15 Gut microbiome composition (summer); LUSC cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.79 0.3 1.6e-8 Personality dimensions; LUSC cis rs61931739 1.000 rs1852223 chr12:34013251 C/T cg06521331 chr12:34319734 NA 0.4 6.57 0.34 1.97e-10 Morning vs. evening chronotype; LUSC cis rs765787 0.530 rs2433228 chr15:45515371 A/C cg25801113 chr15:45476975 SHF 0.34 7.0 0.36 1.37e-11 Uric acid levels; LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg10523679 chr1:76189770 ACADM 0.87 14.29 0.62 1.68e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg23711669 chr6:146136114 FBXO30 0.9 17.03 0.68 2.99e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs6030 0.957 rs4656687 chr1:169505158 T/C cg16792071 chr10:134842795 NA 0.28 6.07 0.32 3.45e-9 Uric acid levels; LUSC cis rs36093844 0.904 rs7101889 chr11:85595579 C/G cg25872744 chr11:85566296 CCDC83 0.43 7.06 0.36 9.73e-12 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs8113142 0.581 rs4804849 chr19:29164489 A/C cg04546413 chr19:29218101 NA 0.43 5.84 0.3 1.24e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs4356932 1.000 rs4417995 chr4:76945999 T/C cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg24503407 chr1:205819492 PM20D1 0.82 15.89 0.66 9.8e-43 Monocyte percentage of white cells; LUSC cis rs1691799 0.899 rs1168299 chr12:66736074 C/G cg16791601 chr12:66731901 HELB -0.71 -12.38 -0.56 3.28e-29 White blood cell count (basophil); LUSC cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.9 0.44 3.72e-17 Menopause (age at onset); LUSC cis rs6840360 0.615 rs62329085 chr4:152470237 G/A cg22705602 chr4:152727874 NA -0.32 -6.47 -0.33 3.41e-10 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.76 -12.44 -0.56 1.88e-29 Colorectal cancer; LUSC cis rs12681288 0.550 rs72507624 chr8:961324 G/A cg15309053 chr8:964076 NA 0.41 8.09 0.4 1.1e-14 Schizophrenia; LUSC cis rs2439831 1.000 rs2601014 chr15:43756013 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.8 7.8 0.39 7.91e-14 Lung cancer in ever smokers; LUSC trans rs17683430 0.702 rs117983733 chr22:32387606 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5.04e-9 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs6951245 1.000 rs74887741 chr7:1110658 G/T cg13565492 chr6:43139072 SRF -0.63 -6.63 -0.34 1.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1670533 1.000 rs1010342 chr4:1068819 C/T cg27284194 chr4:1044797 NA 0.57 8.71 0.43 1.47e-16 Recombination rate (females); LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.06 0.36 9.75e-12 Bipolar disorder; LUSC cis rs17270561 0.609 rs1892248 chr6:25768914 C/T cg16482183 chr6:26056742 HIST1H1C 0.57 7.8 0.39 8.07e-14 Iron status biomarkers; LUSC cis rs7647973 0.593 rs58339610 chr3:49845006 T/A cg13072238 chr3:49761600 GMPPB 0.68 8.8 0.43 7.27e-17 Menarche (age at onset); LUSC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.63 13.71 0.6 3.01e-34 Hemoglobin concentration; LUSC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.31 0.49 8.09e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.85 -14.36 -0.62 9.06e-37 Menarche (age at onset); LUSC cis rs7100689 0.784 rs6585986 chr10:82171559 T/C cg01528321 chr10:82214614 TSPAN14 1.09 17.35 0.69 1.61e-48 Post bronchodilator FEV1; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg27427234 chr20:13201662 ISM1 0.69 5.95 0.31 6.82e-9 Cognitive performance; LUSC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg14196790 chr5:131705035 SLC22A5 -0.36 -5.78 -0.3 1.75e-8 Breast cancer; LUSC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg11812906 chr14:75593930 NEK9 -0.62 -10.16 -0.49 2.68e-21 Height; LUSC cis rs2637266 0.749 rs4979831 chr10:78457588 G/T cg18941641 chr10:78392320 NA 0.34 6.12 0.32 2.59e-9 Pulmonary function; LUSC cis rs8180040 0.593 rs10433549 chr3:47031433 C/T cg27129171 chr3:47204927 SETD2 -0.67 -10.81 -0.51 1.48e-23 Colorectal cancer; LUSC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.62 0.38 2.59e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs739496 1.000 rs7296313 chr12:111878526 T/C cg10833066 chr12:111807467 FAM109A 0.3 5.66 0.3 3.34e-8 Platelet count; LUSC cis rs2191566 1.000 rs369106 chr19:44506930 C/T cg03039196 chr19:44506973 ZNF230 -0.38 -6.18 -0.32 1.86e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs317689 0.819 rs317685 chr12:69715457 A/G cg20891283 chr12:69753455 YEATS4 -0.45 -6.18 -0.32 1.85e-9 Response to diuretic therapy; LUSC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg20891558 chr2:74357851 NA 0.83 14.86 0.63 1.04e-38 Gestational age at birth (maternal effect); LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.24 0.37 3.2e-12 Gut microbiome composition (summer); LUSC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg04248312 chr19:17393744 ANKLE1 -1.03 -16.75 -0.68 3.86e-46 Systemic lupus erythematosus; LUSC cis rs1153858 1.000 rs1719247 chr15:45620985 C/T cg26924012 chr15:45694286 SPATA5L1 1.14 20.47 0.75 6.21e-61 Homoarginine levels; LUSC cis rs2273669 0.667 rs113477421 chr6:109310268 C/T cg05315195 chr6:109294784 ARMC2 -0.53 -5.96 -0.31 6.33e-9 Prostate cancer; LUSC cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg27279351 chr12:120934652 DYNLL1 0.63 8.34 0.42 1.94e-15 High light scatter reticulocyte count; LUSC cis rs754466 0.914 rs12219971 chr10:79701526 T/C cg17075019 chr10:79541650 NA -0.61 -7.96 -0.4 2.75e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2797160 1.000 rs6927161 chr6:126015954 T/C cg05901451 chr6:126070800 HEY2 0.57 8.64 0.43 2.36e-16 Endometrial cancer; LUSC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg02569458 chr12:86230093 RASSF9 0.55 9.38 0.46 1.01e-18 Major depressive disorder; LUSC cis rs6669919 0.540 rs11579048 chr1:211681919 C/G cg10512769 chr1:211675356 NA -0.3 -7.0 -0.36 1.41e-11 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09407429 chr3:4534383 ITPR1 0.42 6.35 0.33 7.09e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs72674100 1.000 rs17026382 chr4:97995366 A/G cg16405019 chr1:18959625 PAX7 -0.62 -6.83 -0.35 3.93e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7481584 0.581 rs399565 chr11:3061780 C/T cg05729581 chr11:3078854 CARS 0.41 6.11 0.32 2.73e-9 Calcium levels; LUSC cis rs4478858 0.684 rs4949202 chr1:31736800 T/C cg00250761 chr1:31883323 NA -0.33 -7.99 -0.4 2.22e-14 Alcohol dependence; LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg08677398 chr8:58056175 NA 0.53 7.12 0.36 6.86e-12 Developmental language disorder (linguistic errors); LUSC cis rs983392 0.776 rs2278867 chr11:59943109 A/T cg24026212 chr11:59952134 MS4A6A -0.37 -6.22 -0.32 1.49e-9 Alzheimer's disease (late onset); LUSC cis rs17102423 0.755 rs11158572 chr14:65577411 C/T cg11161011 chr14:65562177 MAX -0.81 -12.25 -0.56 9.27e-29 Obesity-related traits; LUSC cis rs546131 0.928 rs535719 chr11:34853382 A/G cg11058730 chr11:34937778 PDHX;APIP 0.48 6.53 0.34 2.39e-10 Lung disease severity in cystic fibrosis; LUSC cis rs67366981 0.844 rs2287385 chr14:77715916 C/A cg22824376 chr14:77648248 TMEM63C 0.7 6.4 0.33 5.12e-10 Obsessive-compulsive symptoms; LUSC cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -9.92 -0.48 1.64e-20 Chronic sinus infection; LUSC cis rs2137920 1.000 rs2175918 chr10:50231840 C/T cg27141751 chr10:50231850 C10orf72 0.38 5.76 0.3 1.89e-8 Migraine with aura; LUSC cis rs7616330 0.887 rs2100142 chr3:71112560 A/G cg01511742 chr3:71112437 FOXP1 -0.36 -5.83 -0.3 1.31e-8 QT interval; LUSC cis rs4919694 0.572 rs12255989 chr10:104867206 C/T cg05855489 chr10:104503620 C10orf26 0.54 6.39 0.33 5.67e-10 Arsenic metabolism; LUSC trans rs61931739 0.571 rs4001689 chr12:34243271 C/T cg13010199 chr12:38710504 ALG10B 0.53 8.25 0.41 3.81e-15 Morning vs. evening chronotype; LUSC cis rs4789693 1.000 rs4789693 chr17:80421870 A/C cg04308225 chr17:80449738 NA 0.47 7.67 0.39 1.93e-13 Glucocorticoid-induced osteonecrosis; LUSC cis rs12681287 0.608 rs1135451 chr8:87483608 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg16031515 chr1:205743344 RAB7L1 -0.28 -6.06 -0.31 3.76e-9 Menarche (age at onset); LUSC cis rs12681287 0.752 rs1080170 chr8:87310108 C/T cg27223183 chr8:87520930 FAM82B -0.46 -5.67 -0.3 3.13e-8 Caudate activity during reward; LUSC cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg19628046 chr18:33552617 C18orf21 0.51 6.1 0.32 2.94e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg03354898 chr7:1950403 MAD1L1 0.33 6.49 0.33 3.12e-10 Bipolar disorder and schizophrenia; LUSC cis rs17095355 1.000 rs12247564 chr10:111721400 G/A cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.49 -0.38 6.22e-13 Biliary atresia; LUSC cis rs727505 1.000 rs2286175 chr7:124431032 G/A cg23710748 chr7:124431027 NA -0.43 -7.63 -0.39 2.48e-13 Lewy body disease; LUSC trans rs9847048 0.715 rs6778912 chr3:116368195 T/G cg11621464 chr19:41120268 LTBP4 -0.62 -6.03 -0.31 4.34e-9 Gut microbiome composition (summer); LUSC cis rs4919694 1.000 rs12268849 chr10:104737682 G/A cg04362960 chr10:104952993 NT5C2 1.11 12.91 0.58 3.29e-31 Arsenic metabolism; LUSC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg08888203 chr3:10149979 C3orf24 0.68 9.46 0.46 5.8e-19 Alzheimer's disease; LUSC trans rs853679 0.607 rs13194781 chr6:27815639 A/G cg01620082 chr3:125678407 NA -0.82 -7.32 -0.37 1.84e-12 Depression; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg26373071 chr5:1325741 CLPTM1L 0.41 7.55 0.38 4.06e-13 Lung cancer; LUSC cis rs6964587 1.000 rs11982213 chr7:91722966 A/G cg22709100 chr7:91322751 NA 0.4 5.85 0.3 1.17e-8 Breast cancer; LUSC cis rs1783925 1.000 rs640364 chr11:125300766 G/A cg03464685 chr11:125439445 EI24 -0.47 -6.19 -0.32 1.72e-9 Formal thought disorder in schizophrenia; LUSC cis rs6542838 0.611 rs7588441 chr2:99518858 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.52 -6.92 -0.35 2.37e-11 Fear of minor pain; LUSC cis rs6993244 1 rs6993244 chr8:8863059 C/G cg08975724 chr8:8085496 FLJ10661 0.49 7.14 0.36 5.73e-12 Mean corpuscular hemoglobin; LUSC cis rs116095464 0.558 rs10060089 chr5:205565 G/A cg22857025 chr5:266934 NA -1.19 -13.86 -0.6 7.97e-35 Breast cancer; LUSC cis rs4919694 1.000 rs17727391 chr10:104836101 C/A cg04362960 chr10:104952993 NT5C2 1.18 14.04 0.61 1.62e-35 Arsenic metabolism; LUSC cis rs4363385 0.574 rs4845503 chr1:152959939 A/G cg00922841 chr1:152955080 SPRR1A -0.38 -6.41 -0.33 4.87e-10 Inflammatory skin disease; LUSC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg18681998 chr4:17616180 MED28 0.77 13.57 0.6 1e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1325195 0.881 rs3813643 chr1:179070334 C/G cg11624085 chr17:8464688 MYH10 0.43 7.07 0.36 8.87e-12 IgE grass sensitization; LUSC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg23283495 chr1:209979779 IRF6 0.46 7.53 0.38 4.7e-13 Monobrow; LUSC cis rs7149337 0.805 rs71422017 chr14:51612417 A/T cg23942311 chr14:51606299 NA 0.49 11.51 0.53 4.73e-26 Cancer; LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg04944784 chr2:26401820 FAM59B 0.67 8.92 0.44 3.11e-17 Gut microbiome composition (summer); LUSC cis rs807669 0.869 rs1061325 chr22:19184095 T/C cg02655711 chr22:19163373 SLC25A1 0.59 10.82 0.51 1.37e-23 Metabolite levels; LUSC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg17063962 chr7:91808500 NA 0.58 9.19 0.45 4.45e-18 Breast cancer; LUSC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC trans rs3733585 0.699 rs28837683 chr4:9959808 C/T cg26043149 chr18:55253948 FECH -0.44 -6.8 -0.35 4.9e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg24701985 chr7:149535383 ZNF862 0.44 6.03 0.31 4.46e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2882667 0.690 rs9327829 chr5:138261671 A/G cg04439458 chr5:138467593 SIL1 0.4 7.62 0.39 2.56e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg18110333 chr6:292329 DUSP22 -0.73 -11.92 -0.55 1.57e-27 Menopause (age at onset); LUSC trans rs8073060 0.586 rs72828038 chr17:33893908 C/A cg19694781 chr19:47549865 TMEM160 1.14 18.23 0.71 4.9e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg18402987 chr7:1209562 NA 0.71 7.85 0.39 5.89e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4660306 1.000 rs4660870 chr1:45995231 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -7.01 -0.36 1.29e-11 Homocysteine levels; LUSC cis rs6484504 0.625 rs7940420 chr11:31366700 T/A cg06552810 chr11:31128660 NA 0.4 7.08 0.36 8.6e-12 Red blood cell count; LUSC cis rs2985684 0.894 rs8005990 chr14:50022248 G/A cg04989706 chr14:50066350 PPIL5 -0.45 -6.05 -0.31 3.96e-9 Carotid intima media thickness; LUSC trans rs1448094 0.781 rs7959093 chr12:86335502 C/A cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs7582180 0.629 rs13010911 chr2:100953390 G/C cg08017756 chr2:100939284 LONRF2 -0.47 -8.66 -0.43 2.03e-16 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg26314531 chr2:26401878 FAM59B 0.74 10.04 0.48 6.81e-21 Gut microbiome composition (summer); LUSC cis rs11997175 0.902 rs7462140 chr8:33717880 A/G ch.8.33884649F chr8:33765107 NA 0.42 6.49 0.33 3.18e-10 Body mass index; LUSC cis rs11190604 0.767 rs77838250 chr10:102180090 T/G cg07080220 chr10:102295463 HIF1AN 0.6 8.0 0.4 2.07e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9399401 0.890 rs3817929 chr6:142751062 G/C cg03128060 chr6:142623767 GPR126 0.33 6.1 0.32 2.97e-9 Chronic obstructive pulmonary disease; LUSC cis rs1448094 0.967 rs10863118 chr12:86339232 C/G cg02569458 chr12:86230093 RASSF9 0.42 6.85 0.35 3.49e-11 Major depressive disorder; LUSC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg18306943 chr3:40428807 ENTPD3 0.4 6.11 0.32 2.77e-9 Renal cell carcinoma; LUSC cis rs4891159 0.548 rs10782013 chr18:74128348 C/T cg24786174 chr18:74118243 ZNF516 0.97 21.74 0.77 6.65e-66 Longevity; LUSC cis rs79911532 0.515 rs887579 chr7:75701640 G/A cg03592824 chr7:75666768 STYXL1 0.67 6.42 0.33 4.79e-10 Mononucleosis; LUSC cis rs4363385 0.818 rs1591736 chr1:152987497 A/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.53e-13 Inflammatory skin disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16581840 chr6:137114203 MAP3K5 -0.43 -6.47 -0.33 3.52e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg25174290 chr11:3078921 CARS -0.58 -9.51 -0.46 3.99e-19 Longevity; LUSC cis rs9467773 0.620 rs2451711 chr6:26663110 A/G cg05738196 chr6:26577821 NA 0.79 14.9 0.63 7.47e-39 Intelligence (multi-trait analysis); LUSC trans rs10792665 0.575 rs4625493 chr11:82540975 C/T cg05254078 chr15:34502482 C15orf29 -0.35 -6.04 -0.31 4.06e-9 Obesity-related traits; LUSC trans rs2980439 0.818 rs2948294 chr8:8094961 A/G cg27411982 chr8:10470053 RP1L1 0.41 6.21 0.32 1.56e-9 Neuroticism; LUSC cis rs13006833 0.635 rs291460 chr2:191181585 G/A cg21644426 chr2:191273491 MFSD6 0.43 6.16 0.32 2.13e-9 Urinary metabolites; LUSC trans rs9329221 0.621 rs12156350 chr8:10268516 T/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.55 -0.34 2.21e-10 Neuroticism; LUSC trans rs7916697 0.520 rs10762201 chr10:70040111 A/G cg04882175 chr6:131122610 NA 0.47 6.23 0.32 1.42e-9 Optic disc area; LUSC cis rs4555082 0.915 rs66527719 chr14:105750523 C/G cg13114125 chr14:105738426 BRF1 -0.9 -14.73 -0.63 3.46e-38 Mean platelet volume;Platelet distribution width; LUSC cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6785206 0.892 rs6439143 chr3:128425132 C/T cg16766828 chr3:128327626 NA -0.65 -6.91 -0.35 2.48e-11 Lymphocyte percentage of white cells; LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg24829409 chr8:58192753 C8orf71 -0.59 -6.13 -0.32 2.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg02038168 chr22:39784481 NA -0.47 -7.87 -0.4 5.1e-14 Intelligence (multi-trait analysis); LUSC cis rs9549260 0.755 rs8001443 chr13:41216646 C/T cg21288729 chr13:41239152 FOXO1 -0.62 -9.85 -0.47 2.8e-20 Red blood cell count; LUSC cis rs6987853 0.865 rs2923445 chr8:42400743 C/A cg09913449 chr8:42400586 C8orf40 0.49 8.24 0.41 4.06e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg11764359 chr7:65958608 NA 0.49 6.26 0.32 1.21e-9 Aortic root size; LUSC cis rs9788682 0.948 rs59683676 chr15:78833453 T/C cg24631222 chr15:78858424 CHRNA5 0.84 11.49 0.53 5.46e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg11812906 chr14:75593930 NEK9 -0.67 -11.34 -0.53 1.91e-25 Height; LUSC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg03676636 chr4:99064102 C4orf37 0.36 7.72 0.39 1.35e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs5753618 0.509 rs5753500 chr22:31578879 A/G cg22777020 chr22:31556080 RNF185 -0.46 -5.86 -0.31 1.13e-8 Colorectal cancer; LUSC cis rs5758659 0.652 rs129857 chr22:42399686 C/T cg04733989 chr22:42467013 NAGA -0.38 -6.51 -0.34 2.74e-10 Cognitive function; LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.21 0.37 3.85e-12 Platelet count; LUSC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs478304 0.903 rs1151502 chr11:65503485 G/C cg05805236 chr11:65401703 PCNXL3 0.4 6.82 0.35 4.28e-11 Acne (severe); LUSC cis rs7188861 0.768 rs9939877 chr16:11396779 G/A cg00044050 chr16:11439710 C16orf75 0.55 6.21 0.32 1.55e-9 HDL cholesterol; LUSC cis rs4843747 0.671 rs9933794 chr16:88116981 T/C cg09044154 chr16:88155775 NA -0.53 -7.1 -0.36 7.69e-12 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04723886 chr5:1468204 LPCAT1 0.42 6.15 0.32 2.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4601821 0.895 rs2282511 chr11:113244177 A/C cg14159747 chr11:113255604 NA 0.25 5.83 0.3 1.28e-8 Alcoholic chronic pancreatitis; LUSC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg03806693 chr22:41940476 POLR3H -1.05 -15.08 -0.64 1.51e-39 Vitiligo; LUSC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg27121462 chr16:89883253 FANCA -0.48 -6.83 -0.35 4.13e-11 Vitiligo; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg00106254 chr7:1943704 MAD1L1 -0.42 -6.07 -0.32 3.41e-9 Bipolar disorder and schizophrenia; LUSC trans rs62238980 0.614 rs79397654 chr22:32468027 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs7575217 0.961 rs1192789 chr2:101782754 C/T cg23907051 chr2:101730305 TBC1D8 -0.27 -6.61 -0.34 1.5e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg00311307 chr1:24829359 RCAN3 0.52 6.22 0.32 1.51e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6782228 0.675 rs9813845 chr3:128399623 G/C cg16766828 chr3:128327626 NA -0.31 -5.7 -0.3 2.68e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs4820539 1.000 rs4822362 chr22:23482744 C/A cg21100191 chr22:23484243 RTDR1 0.92 15.99 0.66 4.03e-43 Bone mineral density; LUSC cis rs58950470 0.521 rs7950197 chr11:65446126 T/C cg05805236 chr11:65401703 PCNXL3 -0.33 -5.75 -0.3 1.98e-8 Schizophrenia; LUSC cis rs9457247 0.534 rs7750593 chr6:167387359 C/G cg23791538 chr6:167370224 RNASET2 0.5 8.33 0.41 2.08e-15 Crohn's disease; LUSC cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg08807101 chr21:30365312 RNF160 -0.53 -7.9 -0.4 4.17e-14 Dental caries; LUSC cis rs72781680 0.898 rs72788302 chr2:24107246 C/T cg08917208 chr2:24149416 ATAD2B 0.99 10.33 0.49 6.73e-22 Lymphocyte counts; LUSC cis rs6598955 0.671 rs55791848 chr1:26582711 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs708547 0.836 rs1315005 chr4:57858237 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.92 -0.35 2.35e-11 Response to bleomycin (chromatid breaks); LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs11711311 0.747 rs11928590 chr3:113343478 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.95 -0.31 6.77e-9 IgG glycosylation; LUSC cis rs12681287 0.927 rs2976177 chr8:87332332 A/T cg27223183 chr8:87520930 FAM82B -0.47 -6.25 -0.32 1.23e-9 Caudate activity during reward; LUSC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg17143192 chr8:8559678 CLDN23 0.59 8.53 0.42 5.18e-16 Obesity-related traits; LUSC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.98 -14.45 -0.62 4.11e-37 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22583711 chr7:154795321 PAXIP1;LOC202781 -0.53 -6.76 -0.35 6.03e-11 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.720 rs11170774 chr12:38021722 C/T cg13010199 chr12:38710504 ALG10B -0.61 -9.4 -0.46 9.08e-19 Bladder cancer; LUSC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg02782426 chr3:40428986 ENTPD3 0.32 6.18 0.32 1.87e-9 Renal cell carcinoma; LUSC cis rs28595532 0.800 rs67686161 chr4:119336720 C/T cg21605333 chr4:119757512 SEC24D 0.95 7.97 0.4 2.59e-14 Cannabis dependence symptom count; LUSC trans rs3114020 0.739 rs2622626 chr4:89066715 A/C cg12667048 chr11:70644526 SHANK2 0.34 5.95 0.31 6.76e-9 Gout; LUSC cis rs7296418 0.636 rs11057261 chr12:123797567 T/C cg05973401 chr12:123451056 ABCB9 0.55 8.11 0.41 9.83e-15 Platelet count; LUSC cis rs1969253 0.712 rs843344 chr3:183907032 C/G cg21665078 chr3:183852786 EIF2B5 0.36 5.96 0.31 6.25e-9 Major depressive disorder; LUSC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg06618935 chr21:46677482 NA -0.32 -6.28 -0.33 1.03e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6840360 0.571 rs4696278 chr4:152558978 A/G cg22705602 chr4:152727874 NA -0.3 -6.11 -0.32 2.83e-9 Intelligence (multi-trait analysis); LUSC trans rs4720118 0.875 rs71532576 chr7:33479160 G/T cg23247845 chr10:3679085 NA -0.33 -5.96 -0.31 6.54e-9 Leprosy; LUSC cis rs1865760 1.000 rs9467636 chr6:25919549 A/C cg16482183 chr6:26056742 HIST1H1C 0.44 6.52 0.34 2.67e-10 Height; LUSC cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg06784218 chr1:46089804 CCDC17 -0.47 -8.92 -0.44 3.06e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7572644 0.640 rs4583413 chr2:28074824 C/T cg27432699 chr2:27873401 GPN1 0.51 6.96 0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs12681287 0.673 rs4464946 chr8:87326259 G/A cg27223183 chr8:87520930 FAM82B -0.51 -6.61 -0.34 1.55e-10 Caudate activity during reward; LUSC cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.45 6.48 0.33 3.22e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4243830 0.850 rs7552196 chr1:6590502 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.84 -9.99 -0.48 9.88e-21 Body mass index; LUSC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2762353 0.845 rs35720558 chr6:25784800 A/C cg03264133 chr6:25882463 NA 0.42 7.23 0.37 3.36e-12 Blood metabolite levels; LUSC cis rs826838 0.872 rs826878 chr12:39088837 A/T cg13010199 chr12:38710504 ALG10B -0.6 -9.75 -0.47 6.26e-20 Heart rate; LUSC cis rs3820928 0.874 rs7562776 chr2:227806550 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.14e-13 Pulmonary function; LUSC cis rs6690583 0.623 rs1371140 chr1:85455362 A/C cg11262906 chr1:85462892 MCOLN2 0.67 6.53 0.34 2.51e-10 Serum sulfate level; LUSC cis rs981844 0.775 rs17371545 chr4:154763980 A/G cg14289246 chr4:154710475 SFRP2 -0.48 -6.38 -0.33 5.87e-10 Response to statins (LDL cholesterol change); LUSC cis rs5770917 1.000 rs2073605 chr22:51008850 A/G cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.6 -5.74 -0.3 2.18e-8 Narcolepsy; LUSC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg04727924 chr7:799746 HEATR2 -0.55 -5.87 -0.31 1.05e-8 Cerebrospinal P-tau181p levels; LUSC cis rs877282 0.838 rs11253373 chr10:774857 A/G cg17470449 chr10:769945 NA 0.56 7.79 0.39 8.26e-14 Uric acid levels; LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg00945038 chr17:61921165 SMARCD2 0.53 9.46 0.46 5.6e-19 Prudent dietary pattern; LUSC cis rs1847202 0.787 rs13071878 chr3:72951084 G/A cg25664220 chr3:72788482 NA -0.42 -7.62 -0.38 2.6e-13 Motion sickness; LUSC trans rs1908814 0.516 rs10113062 chr8:11793249 A/G cg08975724 chr8:8085496 FLJ10661 0.48 6.96 0.36 1.79e-11 Neuroticism; LUSC cis rs11696845 0.787 rs6031771 chr20:43363590 C/T cg25301532 chr20:43378953 KCNK15 0.34 6.28 0.32 1.08e-9 Obesity-related traits; LUSC cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.74 0.51 2.66e-23 Schizophrenia; LUSC cis rs1160297 0.609 rs10168840 chr2:53084498 A/G cg07782112 chr2:53107842 NA 0.35 5.96 0.31 6.58e-9 Hemostatic factors and hematological phenotypes; LUSC trans rs2074585 0.647 rs2601188 chr15:90929563 A/G cg10835172 chr15:77224357 RCN2 0.36 5.98 0.31 5.79e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg17063962 chr7:91808500 NA 0.59 9.17 0.45 4.88e-18 Breast cancer; LUSC cis rs6430585 0.583 rs3769012 chr2:136556480 C/T cg07169764 chr2:136633963 MCM6 1.18 17.76 0.7 3.84e-50 Corneal structure; LUSC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC cis rs1790761 1.000 rs1790761 chr11:67221854 T/C cg24690094 chr11:67383802 NA -0.32 -5.77 -0.3 1.84e-8 Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17808901 chr3:39093368 WDR48 0.46 6.82 0.35 4.4e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg08917208 chr2:24149416 ATAD2B 0.55 6.25 0.32 1.24e-9 Lymphocyte counts; LUSC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg14196790 chr5:131705035 SLC22A5 0.45 7.38 0.37 1.27e-12 Breast cancer;Mosquito bite size; LUSC cis rs1355223 0.872 rs12802798 chr11:34747434 T/G cg11058730 chr11:34937778 PDHX;APIP -0.39 -5.67 -0.3 3.13e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2404602 0.692 rs4383105 chr15:77055510 T/C cg22467129 chr15:76604101 ETFA -0.44 -6.99 -0.36 1.47e-11 Blood metabolite levels; LUSC cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg01528321 chr10:82214614 TSPAN14 0.58 8.59 0.43 3.41e-16 Post bronchodilator FEV1; LUSC cis rs908922 0.676 rs3753451 chr1:152485227 T/G cg20991723 chr1:152506922 NA 0.5 9.26 0.45 2.52e-18 Hair morphology; LUSC cis rs72781680 1.000 rs72796389 chr2:24171761 A/G cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -8.4 -0.42 1.29e-15 Bipolar disorder and schizophrenia; LUSC cis rs9303280 0.685 rs9916765 chr17:38005595 T/C cg20243544 chr17:37824526 PNMT 0.4 6.08 0.32 3.3e-9 Self-reported allergy; LUSC cis rs12464483 0.524 rs4952173 chr2:30888346 G/T cg17749961 chr2:30669863 LCLAT1 0.66 8.45 0.42 9.08e-16 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC trans rs6480314 0.542 rs7078967 chr10:70026321 G/T cg20382233 chr11:66045718 CNIH2 0.5 7.1 0.36 7.52e-12 Optic nerve measurement (disc area); LUSC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs12912251 0.894 rs7183893 chr15:38996981 A/C cg01338139 chr15:38987640 C15orf53 -0.51 -7.14 -0.36 5.95e-12 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs12464559 0.522 rs4300824 chr2:152581866 T/C cg01189475 chr2:152685088 ARL5A 0.67 7.37 0.37 1.32e-12 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6964587 0.967 rs6980247 chr7:91594228 T/A cg17063962 chr7:91808500 NA 0.57 9.16 0.45 5.54e-18 Breast cancer; LUSC trans rs6582630 0.519 rs11495700 chr12:38288240 A/G cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs10886558 0.662 rs4752364 chr10:121761821 G/A cg02041677 chr10:121771263 NA -0.34 -5.72 -0.3 2.31e-8 Shingles; LUSC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.94 0.31 7.02e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8099014 1.000 rs8092072 chr18:56129804 C/T cg12907477 chr18:56117327 MIR122 0.43 6.89 0.35 2.86e-11 Platelet count; LUSC cis rs2762353 0.904 rs13197601 chr6:25785935 G/A cg12310025 chr6:25882481 NA 0.43 7.36 0.37 1.49e-12 Blood metabolite levels; LUSC cis rs7851660 0.809 rs7866436 chr9:100650096 G/A cg13688889 chr9:100608707 NA -0.56 -8.55 -0.42 4.47e-16 Strep throat; LUSC cis rs13315871 1.000 rs36037390 chr3:58321954 C/T cg12435725 chr3:58293450 RPP14 -0.72 -7.18 -0.37 4.66e-12 Cholesterol, total; LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg24060327 chr5:131705240 SLC22A5 -0.53 -8.22 -0.41 4.42e-15 Acylcarnitine levels; LUSC cis rs11190604 1.000 rs7084810 chr10:102297546 A/G cg16342193 chr10:102329863 NA -0.36 -6.56 -0.34 2.08e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg21926612 chr6:163149169 PACRG;PARK2 1.15 15.99 0.66 4.08e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg26818010 chr10:134567672 INPP5A -0.86 -11.31 -0.53 2.58e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs12474201 0.889 rs2346878 chr2:46922870 C/T cg06386533 chr2:46925753 SOCS5 0.8 12.2 0.56 1.42e-28 Height; LUSC trans rs961253 0.522 rs2225115 chr20:6360465 C/T cg17788362 chr6:86352627 SYNCRIP 0.43 6.05 0.31 3.93e-9 Colorectal cancer; LUSC cis rs10492096 1.000 rs11064218 chr12:6586261 C/T cg13857086 chr12:6580257 VAMP1 0.77 8.43 0.42 1.02e-15 Hip geometry; LUSC cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.34 -0.37 1.66e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2540226 0.844 rs10169390 chr2:40004249 C/T cg23576258 chr2:39999331 THUMPD2 0.35 6.03 0.31 4.28e-9 Personality dimensions; LUSC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg02079420 chr8:82753780 SNX16 -0.41 -7.1 -0.36 7.56e-12 Diastolic blood pressure; LUSC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg22875332 chr1:76189707 ACADM 0.85 13.7 0.6 3.32e-34 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6502050 0.805 rs62080003 chr17:80078957 C/T cg07393940 chr7:158741817 NA -0.38 -6.8 -0.35 4.71e-11 Life satisfaction; LUSC cis rs713477 0.967 rs10150617 chr14:55916225 A/C cg13175173 chr14:55914753 NA 0.3 6.36 0.33 6.7e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.74 -0.35 6.77e-11 Developmental language disorder (linguistic errors); LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg08200582 chr11:442649 ANO9 -0.51 -5.98 -0.31 5.73e-9 Body mass index; LUSC cis rs11018904 0.906 rs11603498 chr11:89928783 C/A cg26834418 chr11:89957033 CHORDC1 -0.51 -6.02 -0.31 4.67e-9 Intelligence (multi-trait analysis); LUSC cis rs9815354 0.812 rs73069390 chr3:41785513 C/T cg03022575 chr3:42003672 ULK4 0.82 8.32 0.41 2.34e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs4780355 0.843 rs243325 chr16:11354497 A/G cg00044050 chr16:11439710 C16orf75 0.59 9.25 0.45 2.69e-18 Crohn's disease and psoriasis; LUSC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg15147215 chr3:52552868 STAB1 -0.31 -6.0 -0.31 5.02e-9 Bipolar disorder; LUSC cis rs68170813 0.559 rs7794598 chr7:106826381 C/T cg02696742 chr7:106810147 HBP1 -0.63 -9.69 -0.47 9.96e-20 Coronary artery disease; LUSC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg13010199 chr12:38710504 ALG10B 0.7 11.58 0.54 2.59e-26 Heart rate; LUSC trans rs10838798 0.523 rs2019093 chr11:48196553 G/A cg03929089 chr4:120376271 NA -0.43 -5.98 -0.31 5.76e-9 Height; LUSC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg02487422 chr3:49467188 NICN1 0.43 6.03 0.31 4.37e-9 Parkinson's disease; LUSC cis rs2898681 0.618 rs116241740 chr4:53733523 A/G cg00791764 chr4:53727839 RASL11B 0.57 7.35 0.37 1.53e-12 Optic nerve measurement (cup area); LUSC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg11812906 chr14:75593930 NEK9 0.65 11.12 0.52 1.21e-24 Height; LUSC cis rs13256369 0.789 rs13282500 chr8:8568489 A/T cg06671706 chr8:8559999 CLDN23 0.45 6.3 0.33 9.35e-10 Obesity-related traits; LUSC cis rs713587 1.000 rs2384054 chr2:25156773 T/C cg04586622 chr2:25135609 ADCY3 0.34 6.8 0.35 4.75e-11 Body mass index in non-asthmatics; LUSC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg15445000 chr17:37608096 MED1 0.38 6.67 0.34 1.04e-10 Glomerular filtration rate (creatinine); LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg05064044 chr6:292385 DUSP22 -0.73 -11.67 -0.54 1.24e-26 Menopause (age at onset); LUSC cis rs6076065 0.707 rs2024746 chr20:23356862 G/A cg11657817 chr20:23433608 CST11 0.54 11.2 0.52 6.21e-25 Facial morphology (factor 15, philtrum width); LUSC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg04287289 chr16:89883240 FANCA 0.78 6.24 0.32 1.3e-9 Skin colour saturation; LUSC cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg02175503 chr12:58329896 NA 0.58 8.87 0.44 4.52e-17 Intelligence (multi-trait analysis); LUSC cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg16586182 chr3:47516702 SCAP 0.42 5.9 0.31 8.71e-9 Birth weight; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg03790207 chr6:42947109 PEX6 -0.42 -6.17 -0.32 2.02e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7072216 0.763 rs942805 chr10:100168372 G/A cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs3099143 1.000 rs3102712 chr15:77058926 G/A cg21673338 chr15:77095150 SCAPER -0.82 -8.05 -0.4 1.47e-14 Recalcitrant atopic dermatitis; LUSC cis rs708547 0.647 rs1713982 chr4:57881715 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.59 0.38 3.31e-13 Response to bleomycin (chromatid breaks); LUSC cis rs10875595 0.509 rs115819920 chr5:140663745 A/C cg24830062 chr5:140700576 TAF7 -0.52 -6.29 -0.33 1e-9 Pulmonary function decline; LUSC cis rs9677476 0.863 rs12465477 chr2:232073282 G/A cg07929768 chr2:232055508 NA 0.37 7.04 0.36 1.1e-11 Food antigen IgG levels; LUSC cis rs7727544 0.582 rs3749756 chr5:131534499 C/T cg14196790 chr5:131705035 SLC22A5 0.45 7.57 0.38 3.68e-13 Blood metabolite levels; LUSC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg00376283 chr12:123451042 ABCB9 0.68 8.6 0.43 3.1e-16 Neutrophil percentage of white cells; LUSC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg16797656 chr11:68205561 LRP5 -0.42 -7.81 -0.39 7.31e-14 Total body bone mineral density; LUSC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg15556689 chr8:8085844 FLJ10661 0.62 9.74 0.47 6.6e-20 Parkinson's disease; LUSC cis rs453301 0.658 rs9650616 chr8:8869199 T/G cg15556689 chr8:8085844 FLJ10661 -0.63 -9.75 -0.47 6.07e-20 Joint mobility (Beighton score); LUSC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.16 -0.32 2.06e-9 Total body bone mineral density; LUSC trans rs4927850 0.881 rs7624638 chr3:195748729 C/T cg21051086 chr3:73046214 PPP4R2 -0.52 -8.0 -0.4 2.13e-14 Pancreatic cancer; LUSC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg06618935 chr21:46677482 NA 0.32 6.16 0.32 2.12e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg12432903 chr7:1882776 MAD1L1 -0.4 -6.53 -0.34 2.41e-10 Bipolar disorder and schizophrenia; LUSC cis rs9815354 0.812 rs10510732 chr3:42007339 C/T cg03022575 chr3:42003672 ULK4 0.87 8.49 0.42 6.68e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs8038465 0.662 rs57771618 chr15:73967578 T/C cg15420318 chr15:73925796 NPTN 0.56 9.32 0.45 1.6e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg07777115 chr5:623756 CEP72 -0.45 -5.7 -0.3 2.62e-8 Obesity-related traits; LUSC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7107174 1.000 rs4945274 chr11:78109260 G/A cg02023728 chr11:77925099 USP35 0.45 6.83 0.35 4.15e-11 Testicular germ cell tumor; LUSC cis rs765787 0.530 rs28524974 chr15:45543528 C/T cg24006582 chr15:45444508 DUOX1 -0.61 -8.75 -0.43 1.07e-16 Uric acid levels; LUSC trans rs2727020 0.553 rs3907576 chr11:49536639 A/C cg15704280 chr7:45808275 SEPT13 -1.07 -20.13 -0.74 1.45e-59 Coronary artery disease; LUSC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg27532560 chr4:187881888 NA -0.37 -6.08 -0.32 3.33e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.28 0.53 3.14e-25 Menopause (age at onset); LUSC cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg04455712 chr21:45112962 RRP1B 0.46 8.69 0.43 1.64e-16 Mean corpuscular volume; LUSC cis rs936229 0.626 rs3765066 chr15:75140854 G/A cg14664628 chr15:75095509 CSK -0.69 -10.61 -0.5 7.22e-23 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg03929089 chr4:120376271 NA -0.86 -11.79 -0.54 4.74e-27 Height; LUSC cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.73 -0.51 2.85e-23 Alzheimer's disease (late onset); LUSC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11048434 0.736 rs11048195 chr12:9105923 A/G cg13575925 chr12:9217583 LOC144571 0.35 6.47 0.33 3.48e-10 Sjögren's syndrome; LUSC trans rs11039798 0.698 rs76315297 chr11:48240475 T/C cg03929089 chr4:120376271 NA 0.65 6.08 0.32 3.36e-9 Axial length; LUSC cis rs2760061 0.583 rs1745413 chr1:228212456 A/G cg18477163 chr1:228402036 OBSCN 0.57 9.49 0.46 4.62e-19 Diastolic blood pressure; LUSC cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg13256891 chr4:100009986 ADH5 -0.42 -6.07 -0.32 3.43e-9 Alcohol dependence; LUSC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg09699651 chr6:150184138 LRP11 0.37 5.87 0.31 1.04e-8 Lung cancer; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg14424210 chr9:101832044 COL15A1 -0.32 -5.96 -0.31 6.35e-9 Schizophrenia; LUSC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg00701064 chr4:6280414 WFS1 0.59 14.51 0.62 2.4e-37 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs752092 1.000 rs7182945 chr15:101784223 C/T cg19997662 chr15:101784653 CHSY1 -0.42 -6.19 -0.32 1.78e-9 Corneal structure; LUSC cis rs4853525 0.522 rs10490538 chr2:191590066 C/T cg11845111 chr2:191398756 TMEM194B 0.43 5.86 0.31 1.13e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.63 -8.73 -0.43 1.26e-16 Body mass index (adult); LUSC trans rs12188164 1.000 rs56042615 chr5:437667 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 6.04 0.31 4.19e-9 Cystic fibrosis severity; LUSC cis rs7223966 1.000 rs9903897 chr17:61716705 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.45 0.38 8.23e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs909002 0.962 rs10798883 chr1:32140305 C/T cg13919466 chr1:32135498 COL16A1 -0.36 -6.81 -0.35 4.5e-11 Intelligence (multi-trait analysis); LUSC cis rs6469656 0.892 rs10112604 chr8:117756518 C/G cg24004040 chr8:117650383 NA -0.4 -5.97 -0.31 5.95e-9 Colorectal cancer; LUSC cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg23583168 chr7:148888333 NA -0.88 -16.85 -0.68 1.6e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg23630131 chr7:65973040 NA 0.21 5.78 0.3 1.74e-8 Aortic root size; LUSC cis rs11098499 0.954 rs7437420 chr4:120312903 A/G cg09307838 chr4:120376055 NA 0.77 11.08 0.52 1.71e-24 Corneal astigmatism; LUSC cis rs1577917 0.958 rs11755048 chr6:86514334 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.41 -0.33 4.93e-10 Response to antipsychotic treatment; LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs28612505 chr4:97992338 G/T cg16405019 chr1:18959625 PAX7 -0.62 -6.57 -0.34 1.9e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1018836 0.608 rs1015994 chr8:91465011 T/C cg16814680 chr8:91681699 NA -0.54 -7.81 -0.39 7.41e-14 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs66887589 0.627 rs3872807 chr4:120360251 T/A cg09307838 chr4:120376055 NA 0.47 7.0 0.36 1.37e-11 Diastolic blood pressure; LUSC cis rs8114671 0.967 rs2378337 chr20:33771435 G/A cg07148914 chr20:33460835 GGT7 0.47 6.95 0.36 1.92e-11 Height; LUSC trans rs12699921 0.599 rs6973480 chr7:17978129 C/T cg01137537 chr1:162039502 NOS1AP 0.4 5.99 0.31 5.39e-9 Fibrinogen levels; LUSC cis rs72949976 0.584 rs4673729 chr2:214023810 A/G cg08319019 chr2:214017104 IKZF2 0.67 11.55 0.53 3.4e-26 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs2952156 0.959 rs2952151 chr17:37828496 T/C cg20243544 chr17:37824526 PNMT 0.53 7.52 0.38 4.95e-13 Asthma; LUSC trans rs6601327 0.634 rs12679956 chr8:9584849 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.48 -0.33 3.37e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs1524927 1.000 rs13310130 chr7:96346088 T/G cg03808172 chr7:96339361 SHFM1 0.43 6.65 0.34 1.19e-10 Total body bone mineral density; LUSC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg17264618 chr3:40429014 ENTPD3 0.35 7.22 0.37 3.48e-12 Renal cell carcinoma; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg22467129 chr15:76604101 ETFA 0.52 8.78 0.43 8.41e-17 Blood metabolite levels; LUSC cis rs7166081 0.704 rs2414952 chr15:67724392 A/T cg05925327 chr15:68127851 NA -0.41 -6.26 -0.32 1.15e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs877282 0.898 rs11253349 chr10:765897 C/G cg17470449 chr10:769945 NA 0.53 7.09 0.36 8.21e-12 Uric acid levels; LUSC trans rs9329221 0.905 rs6601451 chr8:10243681 C/G cg08975724 chr8:8085496 FLJ10661 -0.47 -6.95 -0.36 1.9e-11 Neuroticism; LUSC cis rs950169 0.922 rs4586394 chr15:84822385 G/A cg12863693 chr15:85201151 NMB -0.35 -7.14 -0.36 5.73e-12 Schizophrenia; LUSC cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg16989719 chr2:238392110 NA 0.36 6.02 0.31 4.51e-9 Prostate cancer; LUSC cis rs7267979 0.934 rs2500399 chr20:25354694 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.57 -0.69 2.11e-49 Liver enzyme levels (alkaline phosphatase); LUSC trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg25482853 chr8:67687455 SGK3 1.2 17.16 0.68 9.11e-48 Lung disease severity in cystic fibrosis; LUSC cis rs7532866 1.000 rs7532866 chr1:26741544 A/G cg17456097 chr1:26900765 RPS6KA1 -0.43 -6.62 -0.34 1.44e-10 Height; LUSC cis rs7481584 0.624 rs438384 chr11:3045651 A/G cg05729581 chr11:3078854 CARS 0.45 6.36 0.33 6.62e-10 Calcium levels; LUSC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.48 9.06 0.44 1.1e-17 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs35110281 0.776 rs9306159 chr21:45061839 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 12.24 0.56 1.06e-28 Mean corpuscular volume; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg16316507 chr7:144533041 TPK1 0.4 6.18 0.32 1.84e-9 Schizophrenia; LUSC cis rs4595586 0.655 rs11831499 chr12:39310114 A/T cg26384229 chr12:38710491 ALG10B 0.45 6.16 0.32 2.09e-9 Morning vs. evening chronotype; LUSC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg17385448 chr1:15911702 AGMAT 0.34 6.0 0.31 5.18e-9 Systolic blood pressure; LUSC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg02569458 chr12:86230093 RASSF9 -0.47 -7.97 -0.4 2.6e-14 Major depressive disorder; LUSC cis rs2573652 0.722 rs12914189 chr15:100544429 A/T cg00587665 chr15:100533223 ADAMTS17 0.38 6.78 0.35 5.58e-11 Height; LUSC trans rs11098499 0.909 rs73842633 chr4:120375464 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.27 0.32 1.1e-9 Corneal astigmatism; LUSC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.19e-30 Aortic root size; LUSC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg23758822 chr17:41437982 NA 1.03 20.56 0.75 2.75e-61 Menopause (age at onset); LUSC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 11.02 0.52 2.66e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg08847533 chr14:75593920 NEK9 -0.83 -15.44 -0.65 5.91e-41 Height; LUSC cis rs4808199 0.895 rs7252888 chr19:19628037 C/T cg03709012 chr19:19516395 GATAD2A 1.05 13.86 0.6 8.33e-35 Nonalcoholic fatty liver disease; LUSC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg06637938 chr14:75390232 RPS6KL1 -0.52 -7.97 -0.4 2.52e-14 Height; LUSC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg13319975 chr6:146136371 FBXO30 -0.51 -7.49 -0.38 6.31e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.588 rs7540609 chr1:153024589 C/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.78 -0.3 1.67e-8 Inflammatory skin disease; LUSC cis rs9303401 0.625 rs66508449 chr17:56691034 T/C cg25039879 chr17:56429692 SUPT4H1 0.66 8.93 0.44 2.93e-17 Cognitive test performance; LUSC cis rs3087591 1.000 rs9902893 chr17:29625638 G/A cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.92 -0.4 3.51e-14 Hip circumference; LUSC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg05802129 chr4:122689817 NA -0.47 -7.82 -0.39 7.15e-14 Type 2 diabetes; LUSC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.15 -0.36 5.49e-12 Major depressive disorder; LUSC cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg05283184 chr6:79620031 NA -0.58 -11.98 -0.55 9.08e-28 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.747 rs4845509 chr1:152981900 T/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.33e-13 Inflammatory skin disease; LUSC cis rs34734847 0.871 rs2239760 chr12:121163518 C/A cg27246729 chr12:121163418 ACADS 0.46 7.36 0.37 1.48e-12 Mean corpuscular volume; LUSC cis rs1997103 1.000 rs6593238 chr7:55411048 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.48 0.38 6.47e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1559088 1.000 rs1559087 chr19:33551041 A/G cg03563238 chr19:33554763 RHPN2 -0.41 -6.45 -0.33 3.91e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs4305317 0.546 rs6544484 chr2:42079411 A/C cg20967028 chr12:14996272 ART4 0.37 6.02 0.31 4.48e-9 Rheumatoid arthritis; LUSC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg18758796 chr5:131593413 PDLIM4 0.34 5.8 0.3 1.54e-8 Blood metabolite levels; LUSC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg16325326 chr1:53192061 ZYG11B 0.96 18.47 0.71 5.49e-53 Monocyte count; LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg08859206 chr1:53392774 SCP2 -0.68 -13.01 -0.58 1.33e-31 Monocyte count; LUSC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.75e-12 Blood metabolite levels; LUSC cis rs134594 1.000 rs134619 chr22:29478374 C/T cg03665785 chr22:29458676 C22orf31 0.28 5.69 0.3 2.78e-8 Birth weight; LUSC cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -11.57 -0.53 2.87e-26 Chronic sinus infection; LUSC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg07636037 chr3:49044803 WDR6 1.05 19.08 0.72 1.98e-55 Parkinson's disease; LUSC cis rs11532322 1 rs11532322 chr12:123731423 A/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.83 -0.35 4.1e-11 Schizophrenia; LUSC cis rs28830936 0.966 rs890498 chr15:42111298 C/G cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.93 -0.31 7.61e-9 Diastolic blood pressure; LUSC cis rs78707713 0.512 rs12772559 chr10:71184356 C/G cg14388049 chr10:71211838 TSPAN15 -0.31 -5.7 -0.3 2.6e-8 Venous thromboembolism; LUSC cis rs2486288 0.656 rs12440356 chr15:45567529 T/C cg26924012 chr15:45694286 SPATA5L1 0.74 10.78 0.51 1.93e-23 Glomerular filtration rate; LUSC cis rs11264213 0.591 rs408986 chr1:36551895 C/T cg27506609 chr1:36549197 TEKT2 0.8 10.51 0.5 1.69e-22 Schizophrenia; LUSC cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg09469691 chr10:81107165 PPIF 0.63 9.3 0.45 1.96e-18 Height; LUSC cis rs950776 0.518 rs12916483 chr15:78832397 G/A cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs2108225 0.934 rs2301989 chr7:107443871 G/A cg18560240 chr7:107437656 SLC26A3 -0.38 -5.79 -0.3 1.66e-8 Ulcerative colitis; LUSC cis rs738322 0.718 rs3761445 chr22:38595411 G/A cg25457927 chr22:38595422 NA 0.52 11.5 0.53 5.21e-26 Cutaneous nevi; LUSC cis rs9372498 0.536 rs62422189 chr6:118907053 C/T cg18833306 chr6:118973337 C6orf204 -0.45 -5.8 -0.3 1.53e-8 Diastolic blood pressure; LUSC cis rs10193935 0.901 rs3088290 chr2:42578143 A/G cg27598129 chr2:42591480 NA -0.63 -8.37 -0.42 1.64e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg21854759 chr1:92012499 NA 0.42 5.74 0.3 2.17e-8 Eosinophil percentage of white cells; LUSC cis rs7584330 0.910 rs66509917 chr2:238395394 T/G cg14458575 chr2:238380390 NA 0.64 11.2 0.52 6.32e-25 Prostate cancer; LUSC cis rs1044826 1.000 rs9848241 chr3:139129631 C/G cg00490450 chr3:139108681 COPB2 0.56 7.39 0.38 1.15e-12 Obesity-related traits; LUSC trans rs62103177 0.535 rs62101568 chr18:77934671 G/A cg05926928 chr17:57297772 GDPD1 0.87 9.19 0.45 4.35e-18 Opioid sensitivity; LUSC trans rs3733585 0.806 rs11723382 chr4:9954660 T/C cg26043149 chr18:55253948 FECH -0.46 -7.1 -0.36 7.56e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7011192 0.793 rs13269921 chr8:10520913 A/G cg17329886 chr8:10513629 RP1L1 0.64 7.28 0.37 2.44e-12 Suicide; LUSC cis rs11585357 0.843 rs113593167 chr1:17613355 G/A cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg22963979 chr7:1858916 MAD1L1 -0.44 -6.62 -0.34 1.39e-10 Schizophrenia; LUSC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg02609749 chr16:89786786 C16orf7;ZNF276 0.57 9.06 0.44 1.11e-17 Vitiligo; LUSC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg12463550 chr7:65579703 CRCP -0.47 -6.93 -0.35 2.17e-11 Aortic root size; LUSC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg07952391 chr2:88470173 THNSL2 -0.58 -7.79 -0.39 8.51e-14 Response to metformin (IC50); LUSC cis rs11098499 0.710 rs6851130 chr4:120133712 G/A cg24375607 chr4:120327624 NA -0.69 -10.96 -0.51 4.56e-24 Corneal astigmatism; LUSC cis rs68092024 0.704 rs793487 chr3:99495422 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -6.21 -0.32 1.55e-9 Cleft lip with or without cleft palate; LUSC trans rs7937682 0.889 rs11213969 chr11:111528441 A/G cg18187862 chr3:45730750 SACM1L 0.55 7.02 0.36 1.27e-11 Primary sclerosing cholangitis; LUSC cis rs11971779 0.680 rs6467843 chr7:139070523 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1256061 0.603 rs1256038 chr14:64740739 T/C cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1577917 0.958 rs6454488 chr6:86450842 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.5 -0.34 2.89e-10 Response to antipsychotic treatment; LUSC cis rs6964587 1.000 rs10243241 chr7:91705696 A/G cg22709100 chr7:91322751 NA 0.39 5.75 0.3 1.98e-8 Breast cancer; LUSC cis rs963731 0.649 rs4670901 chr2:39199271 T/C cg04010122 chr2:39346883 SOS1 -0.78 -5.7 -0.3 2.71e-8 Corticobasal degeneration; LUSC cis rs6484504 0.512 rs2774402 chr11:31312897 G/C cg26647111 chr11:31128758 NA 0.41 5.92 0.31 7.88e-9 Red blood cell count; LUSC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg26119090 chr2:26468346 HADHA;HADHB -0.78 -9.98 -0.48 1.07e-20 Gut microbiome composition (summer); LUSC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg21984481 chr17:79567631 NPLOC4 -0.57 -10.91 -0.51 6.82e-24 Eye color traits; LUSC trans rs62103177 0.733 rs62103232 chr18:77635553 G/A cg14227996 chr4:17616232 MED28 0.82 7.8 0.39 7.87e-14 Opioid sensitivity; LUSC cis rs6964587 1.000 rs2282972 chr7:91666369 C/T cg22709100 chr7:91322751 NA 0.39 5.66 0.3 3.28e-8 Breast cancer; LUSC cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs17086172 0.841 rs76001318 chr18:70271977 G/A cg00123055 chr8:55370951 SOX17 -0.68 -6.06 -0.31 3.61e-9 Airflow obstruction; LUSC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.57 -0.38 3.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg03240473 chr21:43526662 UMODL1;C21orf128 -0.46 -7.18 -0.37 4.64e-12 IgG glycosylation; LUSC cis rs9549260 0.753 rs9549246 chr13:41220755 G/A cg21288729 chr13:41239152 FOXO1 0.58 6.43 0.33 4.37e-10 Red blood cell count; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg15854934 chr14:55518152 MAPK1IP1L 0.5 6.08 0.32 3.21e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7927592 0.830 rs11228240 chr11:68218290 C/T cg01657329 chr11:68192670 LRP5 -0.44 -6.3 -0.33 9.5e-10 Total body bone mineral density; LUSC trans rs7819412 0.668 rs2409714 chr8:11010118 A/G cg15556689 chr8:8085844 FLJ10661 -0.48 -6.99 -0.36 1.55e-11 Triglycerides; LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs6460942 0.915 rs7803002 chr7:12306738 C/T cg06484146 chr7:12443880 VWDE -0.48 -5.71 -0.3 2.56e-8 Coronary artery disease; LUSC cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg22508957 chr16:3507546 NAT15 0.44 6.32 0.33 8.24e-10 Body mass index (adult); LUSC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg22907277 chr7:1156413 C7orf50 0.7 8.19 0.41 5.56e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg09021430 chr5:549028 NA -0.57 -8.71 -0.43 1.45e-16 Obesity-related traits; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg23131131 chr22:24373011 LOC391322 0.45 6.25 0.32 1.27e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3947 0.789 rs9009 chr8:11702006 A/T cg00262122 chr8:11665843 FDFT1 0.51 6.85 0.35 3.65e-11 Blood protein levels; LUSC cis rs12541635 0.677 rs2163124 chr8:107058862 G/T cg10147462 chr8:107024639 NA 0.66 13.82 0.6 1.11e-34 Age of smoking initiation; LUSC cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg08493051 chr2:3487164 NA -0.57 -8.84 -0.44 5.51e-17 Neurofibrillary tangles; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg24003225 chr3:184870891 C3orf70 -0.35 -6.07 -0.32 3.41e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs1991651 0.507 rs17778581 chr8:10743421 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.74 -0.35 7.03e-11 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; LUSC cis rs9952991 1.000 rs9952991 chr18:12780464 G/A cg23544223 chr18:12777786 NA 0.58 6.15 0.32 2.18e-9 Inflammatory skin disease; LUSC cis rs372883 0.554 rs10154065 chr21:30749480 G/C cg24692254 chr21:30365293 RNF160 0.71 11.42 0.53 1.01e-25 Pancreatic cancer; LUSC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.38 5.89 0.31 9.43e-9 Multiple sclerosis; LUSC cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg18721089 chr20:30220636 NA -0.4 -6.68 -0.34 1.02e-10 Mean corpuscular hemoglobin; LUSC cis rs7188873 1 rs7188873 chr16:24727064 A/G cg06028605 chr16:24865363 SLC5A11 -0.35 -6.36 -0.33 6.82e-10 Intelligence (multi-trait analysis); LUSC cis rs36093844 0.898 rs12361645 chr11:85595106 C/G cg25872744 chr11:85566296 CCDC83 -0.46 -6.98 -0.36 1.63e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs3736594 0.513 rs1881396 chr2:27844601 G/T cg27432699 chr2:27873401 GPN1 -0.63 -8.53 -0.42 5.28e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs1790761 0.667 rs658768 chr11:67337808 G/A cg24690094 chr11:67383802 NA 0.44 8.5 0.42 6.36e-16 Mean corpuscular volume; LUSC cis rs7568458 0.684 rs1048740 chr2:85764966 A/T cg23752985 chr2:85803571 VAMP8 0.33 6.34 0.33 7.49e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg15145296 chr3:125709740 NA -0.56 -6.31 -0.33 9e-10 Blood pressure (smoking interaction); LUSC cis rs9929218 0.551 rs2296408 chr16:68713823 A/C cg01251360 chr16:68772225 CDH1 0.27 6.46 0.33 3.61e-10 Colorectal cancer; LUSC cis rs1577917 1.000 rs12207305 chr6:86723502 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.77e-10 Response to antipsychotic treatment; LUSC cis rs908922 0.676 rs7529136 chr1:152516389 T/C cg20991723 chr1:152506922 NA 0.5 9.35 0.46 1.32e-18 Hair morphology; LUSC cis rs28595532 0.623 rs34531766 chr4:119230339 T/C cg21605333 chr4:119757512 SEC24D 0.73 6.2 0.32 1.67e-9 Cannabis dependence symptom count; LUSC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg13607699 chr17:42295918 UBTF 0.53 8.25 0.41 3.6e-15 Total body bone mineral density; LUSC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs10746514 0.833 rs2356925 chr1:232261769 G/A cg09506761 chr1:232265262 NA -0.56 -9.56 -0.46 2.57e-19 Response to statin therapy; LUSC cis rs727505 1.000 rs10464529 chr7:124520308 G/A cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs7580658 0.891 rs55998967 chr2:128048674 A/C cg09760422 chr2:128146352 NA -0.33 -7.24 -0.37 3.06e-12 Protein C levels; LUSC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.86 0.39 5.51e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -13.69 -0.6 3.44e-34 Coronary artery disease; LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1451375 0.572 rs3807558 chr7:50571022 A/G cg18232548 chr7:50535776 DDC -0.53 -7.39 -0.37 1.17e-12 Malaria; LUSC cis rs11098499 0.691 rs9307471 chr4:120261262 G/A cg24375607 chr4:120327624 NA 0.71 11.35 0.53 1.83e-25 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17502984 chr6:80714315 TTK -0.41 -6.0 -0.31 5.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1564892 0.615 rs1843371 chr12:104454042 C/G cg14987745 chr12:104360022 TDG 0.52 5.77 0.3 1.81e-8 Corneal structure; LUSC cis rs9581857 0.685 rs11839899 chr13:28041780 G/A cg22138327 chr13:27999177 GTF3A 0.74 8.04 0.4 1.53e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs34172651 0.917 rs200529 chr16:24758502 T/C cg00339695 chr16:24857497 SLC5A11 -0.38 -6.71 -0.34 8.22e-11 Intelligence (multi-trait analysis); LUSC cis rs6076065 0.707 rs2424555 chr20:23417705 A/G cg11657817 chr20:23433608 CST11 0.51 10.11 0.48 3.9e-21 Facial morphology (factor 15, philtrum width); LUSC cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg25208724 chr1:156163844 SLC25A44 1.05 18.3 0.71 2.53e-52 Testicular germ cell tumor; LUSC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg21951975 chr1:209979733 IRF6 0.58 8.53 0.42 5.09e-16 Cleft lip with or without cleft palate; LUSC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg00933542 chr6:150070202 PCMT1 0.32 6.62 0.34 1.45e-10 Lung cancer; LUSC cis rs41271473 1.000 rs4391638 chr1:228878481 A/C cg10167378 chr1:228756711 NA 0.54 6.59 0.34 1.72e-10 Chronic lymphocytic leukemia; LUSC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC trans rs787274 1.000 rs787272 chr9:115549547 C/T cg12584355 chr7:100773851 SERPINE1 0.57 6.1 0.32 2.95e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg11752832 chr7:134001865 SLC35B4 0.59 9.3 0.45 1.94e-18 Mean platelet volume; LUSC cis rs427941 0.655 rs2734782 chr7:101749667 T/C cg06246474 chr7:101738831 CUX1 0.39 6.33 0.33 8.12e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.53 6.99 0.36 1.5e-11 Multiple sclerosis; LUSC cis rs10779751 1.000 rs11121702 chr1:11293147 C/T cg08854313 chr1:11322531 MTOR 0.87 14.52 0.62 2.22e-37 Body mass index; LUSC cis rs9304742 1.000 rs9304742 chr19:53451291 A/G cg09915433 chr19:53449742 NA -0.64 -10.55 -0.5 1.18e-22 Psoriasis; LUSC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg02018176 chr4:1364513 KIAA1530 0.53 9.15 0.45 5.63e-18 Obesity-related traits; LUSC cis rs6500602 0.793 rs4785964 chr16:4484613 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.46 5.86 0.31 1.09e-8 Schizophrenia; LUSC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg16447950 chr5:562315 NA -0.57 -6.75 -0.35 6.5500000000000006e-11 Lung disease severity in cystic fibrosis; LUSC cis rs7568458 0.905 rs6714709 chr2:85756375 C/G cg17127132 chr2:85788382 GGCX 0.49 8.03 0.4 1.64e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg18404041 chr3:52824283 ITIH1 -0.52 -9.82 -0.47 3.77e-20 Electroencephalogram traits; LUSC cis rs4474465 0.915 rs12273367 chr11:78173835 A/T cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs2235649 0.798 rs9922462 chr16:1848011 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.06 -0.31 3.7e-9 Blood metabolite levels; LUSC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg25456477 chr12:86230367 RASSF9 0.33 5.77 0.3 1.84e-8 Major depressive disorder; LUSC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg04539111 chr16:67997858 SLC12A4 -0.46 -6.27 -0.32 1.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg15485101 chr11:133734466 NA 0.42 7.79 0.39 8.3e-14 Childhood ear infection; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T ch.20.661824R chr20:32868459 AHCY -0.5 -6.9 -0.35 2.68e-11 Hepatitis; LUSC cis rs12824058 0.798 rs7968728 chr12:130804696 T/A cg26677194 chr12:130822605 PIWIL1 0.56 8.39 0.42 1.4e-15 Menopause (age at onset); LUSC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg23887609 chr12:130822674 PIWIL1 0.49 7.27 0.37 2.65e-12 Menopause (age at onset); LUSC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg03676636 chr4:99064102 C4orf37 0.31 6.74 0.35 6.93e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.49e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7560272 0.682 rs2421546 chr2:73641077 A/C cg20560298 chr2:73613845 ALMS1 0.48 7.45 0.38 8.26e-13 Schizophrenia; LUSC cis rs8078723 0.668 rs56030650 chr17:38131187 C/A cg17344932 chr17:38183730 MED24;SNORD124 -0.53 -8.92 -0.44 3.2e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs983392 0.679 rs6591559 chr11:60025565 C/T cg20284999 chr11:59952153 MS4A6A -0.39 -6.38 -0.33 5.85e-10 Alzheimer's disease (late onset); LUSC cis rs75920871 0.528 rs12274388 chr11:116946238 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.48 -0.33 3.25e-10 Subjective well-being; LUSC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg23978390 chr7:1156363 C7orf50 0.48 5.67 0.3 3.06e-8 Bronchopulmonary dysplasia; LUSC cis rs10791323 0.569 rs329664 chr11:133754975 G/T cg00579200 chr11:133705235 NA -0.39 -5.9 -0.31 9.02e-9 Childhood ear infection; LUSC cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.21 -0.41 4.82e-15 Axial length; LUSC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg02487422 chr3:49467188 NICN1 0.45 7.07 0.36 9.28e-12 Resting heart rate; LUSC cis rs9527 0.615 rs10883800 chr10:104671212 A/C cg08330031 chr10:104623503 C10orf32 0.32 5.69 0.3 2.76e-8 Arsenic metabolism; LUSC cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.57 0.57 6.1e-30 Motion sickness; LUSC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg17764715 chr19:33622953 WDR88 0.54 8.09 0.4 1.15e-14 Colorectal cancer; LUSC cis rs13315871 1.000 rs9862969 chr3:58341917 A/G cg20936604 chr3:58311152 NA -0.72 -7.09 -0.36 8.14e-12 Cholesterol, total; LUSC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC cis rs28595532 0.668 rs56410164 chr4:119331625 A/G cg02775129 chr4:119771670 NA -0.76 -6.31 -0.33 8.88e-10 Cannabis dependence symptom count; LUSC cis rs472402 0.623 rs7707877 chr5:6635946 C/G cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.48 -7.17 -0.37 4.75e-12 Response to amphetamines; LUSC cis rs7851660 0.809 rs7031386 chr9:100665669 G/T cg13688889 chr9:100608707 NA -0.54 -8.43 -0.42 1.05e-15 Strep throat; LUSC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.68 -0.34 9.77e-11 Lung cancer; LUSC cis rs1215050 0.791 rs7434393 chr4:98768576 T/C cg05340658 chr4:99064831 C4orf37 0.45 7.08 0.36 8.69e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.56 9.53 0.46 3.4e-19 IgG glycosylation; LUSC trans rs9467711 0.790 rs13220495 chr6:26441640 C/T cg06606381 chr12:133084897 FBRSL1 -0.74 -6.08 -0.32 3.22e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg11812906 chr14:75593930 NEK9 0.66 11.51 0.53 4.73e-26 Height; LUSC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg17279839 chr7:150038598 RARRES2 0.4 6.23 0.32 1.44e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs7769051 0.522 rs73554461 chr6:133139087 T/G cg05787951 chr6:166100605 NA 0.56 6.04 0.31 4.1e-9 Type 2 diabetes nephropathy; LUSC trans rs9951602 0.920 rs3859334 chr18:76684193 G/A cg02800362 chr5:177631904 HNRNPAB 0.67 7.29 0.37 2.27e-12 Obesity-related traits; LUSC cis rs4654899 0.733 rs6698440 chr1:21258712 C/T cg01072550 chr1:21505969 NA -0.54 -8.17 -0.41 6.33e-15 Superior frontal gyrus grey matter volume; LUSC cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.75 0.65 3.5e-42 Bladder cancer; LUSC cis rs73200209 0.744 rs17498543 chr12:116581796 T/C cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs9300255 0.639 rs941306 chr12:123715113 C/T cg05973401 chr12:123451056 ABCB9 0.53 6.59 0.34 1.73e-10 Neutrophil percentage of white cells; LUSC cis rs7267979 0.932 rs431579 chr20:25470056 T/C cg08601574 chr20:25228251 PYGB 0.42 6.36 0.33 6.79e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg19230755 chr7:65878503 NA -0.4 -5.65 -0.3 3.35e-8 Aortic root size; LUSC cis rs709400 0.663 rs62007681 chr14:103884651 G/A cg12935359 chr14:103987150 CKB -0.57 -8.71 -0.43 1.45e-16 Body mass index; LUSC cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg05343316 chr1:45956843 TESK2 0.74 9.99 0.48 9.68e-21 Platelet count; LUSC cis rs317689 0.513 rs317659 chr12:69686132 T/A cg20891283 chr12:69753455 YEATS4 0.62 9.81 0.47 4.06e-20 Response to diuretic therapy; LUSC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg12560992 chr17:57184187 TRIM37 -0.84 -15.34 -0.64 1.38e-40 Intelligence (multi-trait analysis); LUSC cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg11645453 chr3:52864694 ITIH4 0.43 9.04 0.44 1.27e-17 Schizophrenia; LUSC trans rs7726839 0.540 rs4957083 chr5:659343 T/C cg25482853 chr8:67687455 SGK3 1.09 15.45 0.65 5.28e-41 Obesity-related traits; LUSC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg05025164 chr4:1340916 KIAA1530 -0.48 -7.35 -0.37 1.55e-12 Obesity-related traits; LUSC cis rs4851254 0.618 rs13033732 chr2:100644797 A/G cg22139774 chr2:100720529 AFF3 -0.44 -5.79 -0.3 1.65e-8 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg08684580 chr7:98029266 BAIAP2L1 0.38 7.0 0.36 1.4e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg25204440 chr1:209979598 IRF6 0.52 6.94 0.35 2.1e-11 Cleft lip with or without cleft palate; LUSC cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.42 6.4 0.33 5.12e-10 Colorectal cancer; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg21303682 chr7:7606373 MIOS 0.41 6.23 0.32 1.38e-9 Schizophrenia; LUSC cis rs11190604 1.000 rs3763695 chr10:102269206 A/G cg23241863 chr10:102295624 HIF1AN 0.5 6.16 0.32 2.15e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6582630 0.576 rs2222345 chr12:38356020 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.19 -0.41 5.54e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs3760982 0.585 rs67773424 chr19:44293994 G/A cg11993925 chr19:44307056 LYPD5 0.35 7.57 0.38 3.59e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs2760061 0.583 rs697763 chr1:228192622 G/C cg04850211 chr1:228464232 OBSCN -0.37 -6.2 -0.32 1.62e-9 Diastolic blood pressure; LUSC cis rs546131 0.928 rs550313 chr11:34830919 C/T cg11058730 chr11:34937778 PDHX;APIP 0.47 6.3 0.33 9.12e-10 Lung disease severity in cystic fibrosis; LUSC cis rs9486719 1.000 rs9486719 chr6:97060124 G/A cg06623918 chr6:96969491 KIAA0776 -0.78 -9.68 -0.47 1.11e-19 Migraine;Coronary artery disease; LUSC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.83 -13.29 -0.59 1.19e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.72 0.39 1.4e-13 Bipolar disorder; LUSC cis rs2486288 0.656 rs7167146 chr15:45571386 A/G cg14582100 chr15:45693742 SPATA5L1 0.43 7.58 0.38 3.42e-13 Glomerular filtration rate; LUSC cis rs10193935 0.892 rs6744964 chr2:42441088 A/G cg27598129 chr2:42591480 NA -0.62 -8.47 -0.42 7.98e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg12560992 chr17:57184187 TRIM37 0.64 10.99 0.52 3.38e-24 Intelligence (multi-trait analysis); LUSC cis rs394563 0.591 rs805026 chr6:149728254 G/C cg03678062 chr6:149772716 ZC3H12D -0.3 -6.2 -0.32 1.7e-9 Dupuytren's disease; LUSC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11644478 chr21:40555479 PSMG1 0.8 14.71 0.63 4.16e-38 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09350387 chr2:170430441 FASTKD1 -0.39 -5.95 -0.31 6.92e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1728785 1.000 rs1624718 chr16:68580385 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg04025307 chr7:1156635 C7orf50 0.38 5.87 0.31 1.06e-8 Longevity;Endometriosis; LUSC cis rs17253792 0.822 rs112308750 chr14:56080073 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg26380479 chr7:97908229 NA -0.28 -6.3 -0.33 9.42e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs34172651 0.917 rs11642302 chr16:24770856 G/A cg06028605 chr16:24865363 SLC5A11 0.47 8.55 0.42 4.35e-16 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg17376030 chr22:41985996 PMM1 -0.47 -6.0 -0.31 5.08e-9 Vitiligo; LUSC trans rs9650657 0.504 rs2409724 chr8:11041642 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.87 -0.4 4.86e-14 Neuroticism; LUSC cis rs1712517 1.000 rs3123794 chr10:105033742 A/G cg05636881 chr10:105038444 INA 0.39 6.72 0.35 7.82e-11 Migraine; LUSC cis rs1577917 1.000 rs12200330 chr6:86656653 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.88 -0.35 2.92e-11 Response to antipsychotic treatment; LUSC cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs6545883 0.894 rs1186703 chr2:61672965 A/C cg15711740 chr2:61764176 XPO1 -0.46 -7.1 -0.36 7.37e-12 Tuberculosis; LUSC cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg24642439 chr20:33292090 TP53INP2 0.48 7.24 0.37 3.08e-12 Glomerular filtration rate (creatinine); LUSC cis rs500891 0.525 rs6926600 chr6:84109322 A/G cg08257003 chr6:84140564 ME1 0.34 7.31 0.37 1.93e-12 Platelet-derived growth factor BB levels; LUSC cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14442939 chr10:27389572 ANKRD26 0.79 8.68 0.43 1.73e-16 Breast cancer; LUSC cis rs8063160 0.799 rs1805007 chr16:89986117 A/G cg07984980 chr16:89898383 SPIRE2 -0.82 -7.19 -0.37 4.22e-12 Red vs non-red hair color;Light vs. dark hair color;Brown vs. non-brown hair color; LUSC trans rs7615952 0.641 rs4422257 chr3:125774363 A/G cg07211511 chr3:129823064 LOC729375 -0.77 -9.84 -0.47 3.18e-20 Blood pressure (smoking interaction); LUSC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg08219700 chr8:58056026 NA 0.56 6.75 0.35 6.65e-11 Developmental language disorder (linguistic errors); LUSC cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg00852783 chr1:26633632 UBXN11 0.49 8.71 0.43 1.45e-16 Obesity-related traits; LUSC cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg17845761 chr1:175162550 KIAA0040 0.3 5.8 0.3 1.56e-8 Alcohol dependence; LUSC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg21984481 chr17:79567631 NPLOC4 0.58 11.22 0.52 5.07e-25 Eye color traits; LUSC trans rs8030485 0.571 rs7174337 chr15:79441373 C/A cg16586880 chr8:140854244 TRAPPC9 -0.38 -6.16 -0.32 2.11e-9 Left ventricle wall thickness; LUSC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg04166393 chr7:2884313 GNA12 0.44 5.69 0.3 2.71e-8 Height; LUSC cis rs694739 0.657 rs11231770 chr11:64140625 G/A cg26898376 chr11:64110657 CCDC88B 0.31 5.81 0.3 1.45e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs738321 0.701 rs2413506 chr22:38593128 T/C cg25457927 chr22:38595422 NA -0.45 -8.44 -0.42 9.95e-16 Breast cancer; LUSC cis rs472402 0.540 rs2288445 chr5:6620092 C/T cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.52 -7.49 -0.38 6.3e-13 Response to amphetamines; LUSC cis rs394563 0.591 rs6570963 chr6:149691355 T/G cg07828024 chr6:149772892 ZC3H12D 0.33 7.2 0.37 4.06e-12 Dupuytren's disease; LUSC trans rs9467603 1.000 rs6902211 chr6:25767437 G/A cg06606381 chr12:133084897 FBRSL1 0.58 6.16 0.32 2.12e-9 Intelligence (multi-trait analysis); LUSC cis rs7572733 0.515 rs700675 chr2:198700216 G/A cg00792783 chr2:198669748 PLCL1 0.43 5.7 0.3 2.66e-8 Dermatomyositis; LUSC trans rs72674100 1.000 rs10005324 chr4:97989202 G/C cg16405019 chr1:18959625 PAX7 -0.61 -6.44 -0.33 4.04e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12493885 0.729 rs10513452 chr3:153640429 A/C cg17054900 chr3:154042577 DHX36 -0.58 -6.03 -0.31 4.32e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9388451 0.839 rs3799709 chr6:126078361 A/G cg05901451 chr6:126070800 HEY2 -0.96 -19.28 -0.73 3.47e-56 Brugada syndrome; LUSC cis rs6906287 0.669 rs2356491 chr6:118806564 A/G cg21191810 chr6:118973309 C6orf204 0.33 5.84 0.3 1.21e-8 Electrocardiographic conduction measures; LUSC cis rs8062405 1.000 rs12443881 chr16:28841777 C/T cg09754948 chr16:28834200 ATXN2L 0.43 6.21 0.32 1.54e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg25456477 chr12:86230367 RASSF9 0.4 6.87 0.35 3.16e-11 Major depressive disorder; LUSC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg18876405 chr7:65276391 NA -0.55 -8.77 -0.43 9.25e-17 Aortic root size; LUSC cis rs8099014 0.861 rs6566969 chr18:56118999 A/G cg12907477 chr18:56117327 MIR122 0.44 6.95 0.36 1.92e-11 Platelet count; LUSC cis rs870825 0.616 rs6552809 chr4:185643984 G/A cg04058563 chr4:185651563 MLF1IP 0.83 13.04 0.58 1.05e-31 Blood protein levels; LUSC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC trans rs17685 0.753 rs1574107 chr7:75685047 A/C cg19862616 chr7:65841803 NCRNA00174 1.12 19.19 0.72 7.34e-56 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs2898290 0.622 rs978802 chr8:11343278 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.43 -0.42 1.03e-15 Systolic blood pressure; LUSC cis rs60695258 0.550 rs388401 chr4:87974415 C/G cg10685359 chr4:87814065 C4orf36 0.35 6.24 0.32 1.32e-9 Hematocrit; LUSC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.22 0.37 3.51e-12 Gut microbiome composition (summer); LUSC cis rs7267979 0.844 rs6115188 chr20:25432170 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.78 16.49 0.67 4.05e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg21951975 chr1:209979733 IRF6 0.59 6.97 0.36 1.75e-11 Cleft lip with or without cleft palate; LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg16325326 chr1:53192061 ZYG11B 0.7 11.26 0.52 3.77e-25 Monocyte count; LUSC cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg18755752 chr8:142205143 DENND3 -0.52 -8.33 -0.41 2.15e-15 Immature fraction of reticulocytes; LUSC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg23601095 chr6:26197514 HIST1H3D 0.67 7.15 0.36 5.37e-12 Gout;Renal underexcretion gout; LUSC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg21573476 chr21:45109991 RRP1B -0.36 -5.77 -0.3 1.8e-8 Mean corpuscular volume; LUSC cis rs12310956 0.510 rs4931743 chr12:33867588 T/C cg06521331 chr12:34319734 NA -0.37 -6.07 -0.32 3.55e-9 Morning vs. evening chronotype; LUSC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg26850624 chr5:429559 AHRR -0.43 -8.21 -0.41 4.89e-15 Cystic fibrosis severity; LUSC cis rs4654899 0.865 rs10493006 chr1:21375904 G/A cg01072550 chr1:21505969 NA -0.54 -7.91 -0.4 3.73e-14 Superior frontal gyrus grey matter volume; LUSC trans rs225245 0.782 rs321601 chr17:33892087 A/C cg19694781 chr19:47549865 TMEM160 0.41 6.5 0.34 2.94e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs17433780 0.897 rs12120863 chr1:89501522 T/C cg09516651 chr1:89888402 LOC400759 0.57 9.93 0.48 1.53e-20 Carotid intima media thickness; LUSC cis rs11958404 0.932 rs72816583 chr5:157432647 T/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs3820068 0.603 rs1980607 chr1:15975237 A/G cg24675056 chr1:15929824 NA 0.44 7.56 0.38 3.98e-13 Systolic blood pressure; LUSC trans rs7824557 0.836 rs765731 chr8:11121498 T/A cg06636001 chr8:8085503 FLJ10661 -0.55 -8.44 -0.42 9.75e-16 Retinal vascular caliber; LUSC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg18876405 chr7:65276391 NA 0.68 12.22 0.56 1.26e-28 Aortic root size; LUSC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg07701084 chr6:150067640 NUP43 0.54 8.25 0.41 3.73e-15 Lung cancer; LUSC cis rs6964587 1.000 rs6465347 chr7:91693837 A/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 7.75 0.39 1.11e-13 Urate levels; LUSC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg12463550 chr7:65579703 CRCP -0.56 -8.41 -0.42 1.19e-15 Aortic root size; LUSC cis rs9788721 0.836 rs17483929 chr15:78742376 C/T cg18825076 chr15:78729989 IREB2 -0.57 -9.11 -0.45 7.66e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.07 -0.32 3.42e-9 Total body bone mineral density; LUSC cis rs11190604 1.000 rs4919468 chr10:102288343 G/C cg16342193 chr10:102329863 NA -0.38 -6.67 -0.34 1.09e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg14784868 chr12:69753453 YEATS4 0.82 13.94 0.61 3.87e-35 Blood protein levels; LUSC cis rs7903847 0.642 rs11189163 chr10:99121361 C/T cg20016023 chr10:99160130 RRP12 -0.29 -6.2 -0.32 1.7e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg05347473 chr6:146136440 FBXO30 0.44 7.52 0.38 5.13e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4561483 0.583 rs17236573 chr16:11994655 G/C cg08843971 chr16:11963173 GSPT1 0.41 6.23 0.32 1.41e-9 Testicular germ cell tumor; LUSC cis rs2625529 0.762 rs1384007 chr15:72229534 T/C cg16672083 chr15:72433130 SENP8 -0.5 -7.35 -0.37 1.56e-12 Red blood cell count; LUSC cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg12011299 chr4:100065546 ADH4 0.72 13.69 0.6 3.73e-34 Alcohol dependence; LUSC cis rs617219 0.746 rs56246109 chr5:78515198 T/G cg24856658 chr5:78533917 JMY -0.31 -6.01 -0.31 4.89e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs2282802 0.660 rs6873248 chr5:139683762 A/G cg26211634 chr5:139558579 C5orf32 -0.39 -7.32 -0.37 1.81e-12 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.959 rs16876540 chr6:86612519 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.67 -0.43 1.93e-16 Response to antipsychotic treatment; LUSC cis rs3862030 0.694 rs12781742 chr10:104227469 G/A cg05855489 chr10:104503620 C10orf26 0.49 7.4 0.38 1.1e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs4853012 0.752 rs13413795 chr2:74349839 G/A cg05890377 chr2:74357713 NA 0.72 13.39 0.59 5.1e-33 Gestational age at birth (maternal effect); LUSC cis rs6961069 0.585 rs1984112 chr7:80242920 A/G cg04458919 chr7:80252533 CD36 -0.4 -6.94 -0.36 2e-11 Platelet count; LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg27170947 chr2:26402098 FAM59B 0.63 9.8 0.47 4.21e-20 Gut microbiome composition (summer); LUSC cis rs3540 0.574 rs2601205 chr15:90961813 A/G cg22089800 chr15:90895588 ZNF774 0.6 9.35 0.46 1.28e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26580134 chr2:60777051 BCL11A -0.43 -6.36 -0.33 6.46e-10 Electrocardiographic conduction measures; LUSC cis rs7903847 0.642 rs10882915 chr10:99142184 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.57e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg06481639 chr22:41940642 POLR3H -0.54 -6.38 -0.33 5.76e-10 Vitiligo; LUSC cis rs6547741 0.844 rs9941696 chr2:27920064 C/T cg27432699 chr2:27873401 GPN1 -0.88 -17.24 -0.69 4.35e-48 Oral cavity cancer; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg02475777 chr4:1388615 CRIPAK 0.37 5.65 0.3 3.46e-8 Obesity-related traits; LUSC cis rs58804349 0.685 rs9422671 chr10:43288626 T/G cg08461752 chr10:43522343 NA -0.6 -6.1 -0.32 2.94e-9 Pediatric bone mineral content (radius); LUSC cis rs9814567 1.000 rs4535272 chr3:134299916 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg14456004 chr13:21872349 NA 1.27 19.46 0.73 6.49e-57 White matter hyperintensity burden; LUSC cis rs10883723 0.962 rs1056739 chr10:104236542 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 12.06 0.55 4.66e-28 Allergic disease (asthma, hay fever or eczema); LUSC trans rs9393777 0.778 rs35608615 chr6:27040402 G/C cg06606381 chr12:133084897 FBRSL1 -0.69 -7.37 -0.37 1.34e-12 Intelligence (multi-trait analysis); LUSC cis rs6580649 1.000 rs6580647 chr12:48403229 G/T cg05342945 chr12:48394962 COL2A1 0.4 5.67 0.3 3.1e-8 Lung cancer; LUSC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg09455208 chr3:40491958 NA 0.52 9.45 0.46 6.03e-19 Renal cell carcinoma; LUSC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg14298792 chr15:30685198 CHRFAM7A 0.63 8.17 0.41 6.3e-15 Huntington's disease progression; LUSC cis rs708547 1.000 rs10003229 chr4:57809598 A/C cg25525207 chr4:57843836 C4orf14;POLR2B 0.46 5.69 0.3 2.84e-8 Response to bleomycin (chromatid breaks); LUSC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.85 -0.35 3.58e-11 Lung cancer; LUSC cis rs3008870 0.701 rs2815358 chr1:67493778 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.32 0.56 5.39e-29 Lymphocyte percentage of white cells; LUSC cis rs2219968 0.962 rs7817567 chr8:78937473 A/T cg00738934 chr8:78996279 NA 0.4 7.18 0.37 4.66e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs8072100 1.000 rs4794048 chr17:45763073 A/C cg25173405 chr17:45401733 C17orf57 -0.38 -6.17 -0.32 1.93e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11190604 0.790 rs11190535 chr10:102197441 A/T cg07080220 chr10:102295463 HIF1AN 0.61 8.14 0.41 8.11e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs13315871 0.929 rs9871725 chr3:58292525 T/G cg20936604 chr3:58311152 NA -0.71 -6.68 -0.34 9.96e-11 Cholesterol, total; LUSC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg12463550 chr7:65579703 CRCP 0.54 8.11 0.41 9.64e-15 Aortic root size; LUSC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg12463550 chr7:65579703 CRCP 0.42 5.97 0.31 6.11e-9 Aortic root size; LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg23758822 chr17:41437982 NA 1.04 19.77 0.73 3.88e-58 Menopause (age at onset); LUSC cis rs17253792 0.822 rs17683728 chr14:56060389 C/T cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs7107174 0.892 rs2090095 chr11:78034020 G/A cg02023728 chr11:77925099 USP35 0.46 6.9 0.35 2.56e-11 Testicular germ cell tumor; LUSC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg12463550 chr7:65579703 CRCP 0.42 6.07 0.32 3.49e-9 Aortic root size; LUSC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg12560992 chr17:57184187 TRIM37 0.84 15.24 0.64 3.63e-40 Intelligence (multi-trait analysis); LUSC cis rs1865760 1.000 rs9393675 chr6:25930116 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 6.58 0.34 1.79e-10 Height; LUSC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg07936489 chr17:37558343 FBXL20 -0.7 -9.74 -0.47 6.83e-20 Glomerular filtration rate (creatinine); LUSC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg07701084 chr6:150067640 NUP43 0.57 8.79 0.43 7.84e-17 Lung cancer; LUSC cis rs7264396 0.563 rs11906854 chr20:34383634 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -7.52 -0.38 5.25e-13 Total cholesterol levels; LUSC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg09509183 chr1:209979624 IRF6 0.4 6.1 0.32 3e-9 Monobrow; LUSC cis rs17253792 0.822 rs12100753 chr14:56042870 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.29 -0.37 2.25e-12 Putamen volume; LUSC cis rs7575217 0.552 rs13006193 chr2:101665915 G/A cg23907051 chr2:101730305 TBC1D8 0.27 6.69 0.34 9.46e-11 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.19 0.41 5.6e-15 Prudent dietary pattern; LUSC cis rs6754311 0.509 rs3820794 chr2:136505546 C/T cg07169764 chr2:136633963 MCM6 -0.76 -10.14 -0.49 3.07e-21 Mosquito bite size; LUSC trans rs11039798 0.764 rs1121450 chr11:48897476 C/T cg15704280 chr7:45808275 SEPT13 0.77 7.3 0.37 2.07e-12 Axial length; LUSC cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg18132916 chr6:79620363 NA -0.37 -5.65 -0.3 3.41e-8 Intelligence (multi-trait analysis); LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.46 -7.33 -0.37 1.72e-12 Systemic lupus erythematosus; LUSC cis rs9902453 0.730 rs2020939 chr17:28550732 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.51 -7.49 -0.38 6.11e-13 Coffee consumption (cups per day); LUSC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg03433033 chr1:76189801 ACADM -0.87 -18.4 -0.71 1.1e-52 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg01516881 chr6:292596 DUSP22 -0.53 -7.85 -0.39 5.63e-14 Menopause (age at onset); LUSC cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg02527881 chr3:46936655 PTH1R 0.39 6.85 0.35 3.66e-11 Colorectal cancer; LUSC cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg19539972 chr4:7069911 GRPEL1 -0.7 -7.63 -0.39 2.46e-13 Monocyte percentage of white cells; LUSC cis rs7582720 0.943 rs72934551 chr2:203984117 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.61 0.43 2.86e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.84 13.02 0.58 1.28e-31 Cognitive test performance; LUSC cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs1728785 1.000 rs1170431 chr16:68605639 T/C cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.88 -0.31 1.02e-8 Alzheimer's disease (late onset); LUSC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg18190219 chr22:46762943 CELSR1 -0.62 -6.3 -0.33 9.22e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg10018233 chr7:150070692 REPIN1 0.38 6.73 0.35 7.52e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs11098499 0.863 rs6534139 chr4:120449456 A/G cg09307838 chr4:120376055 NA -0.76 -10.57 -0.5 1e-22 Corneal astigmatism; LUSC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg19729930 chr2:74357872 NA 0.66 9.48 0.46 4.78e-19 Gestational age at birth (maternal effect); LUSC cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg02527881 chr3:46936655 PTH1R -0.38 -6.77 -0.35 5.92e-11 Colorectal cancer; LUSC cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.42 6.17 0.32 1.96e-9 Schizophrenia; LUSC cis rs4737010 0.501 rs7000282 chr8:41647493 A/C cg17182837 chr8:41585554 ANK1 -0.39 -6.72 -0.35 7.87e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg17385448 chr1:15911702 AGMAT 0.37 6.23 0.32 1.41e-9 Systolic blood pressure; LUSC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg07343612 chr16:622815 PIGQ -0.76 -13.4 -0.59 4.63e-33 Height; LUSC trans rs1493916 0.905 rs10460051 chr18:31413679 C/T cg27147174 chr7:100797783 AP1S1 -0.65 -10.37 -0.49 5.19e-22 Life satisfaction; LUSC cis rs7582720 1.000 rs114527590 chr2:203787405 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg00908189 chr16:619842 PIGQ 0.68 10.79 0.51 1.79e-23 Height; LUSC cis rs12477438 0.765 rs12612688 chr2:99613091 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.84 -12.34 -0.56 4.25e-29 Chronic sinus infection; LUSC cis rs4595586 0.546 rs10876163 chr12:39244915 G/A cg26384229 chr12:38710491 ALG10B 0.79 11.97 0.55 1.05e-27 Morning vs. evening chronotype; LUSC cis rs1775715 0.705 rs2778651 chr10:32106575 C/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.67 0.39 1.89e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg07741184 chr6:167504864 NA 0.4 7.09 0.36 8.08e-12 Crohn's disease; LUSC trans rs12579753 0.917 rs12311988 chr12:82177209 C/A cg07923666 chr12:49932857 KCNH3 -0.49 -6.18 -0.32 1.88e-9 Resting heart rate; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg13685833 chr1:53393034 SCP2 0.4 5.98 0.31 5.78e-9 Monocyte count; LUSC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs3755132 0.929 rs4668949 chr2:15771615 C/T cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs9309473 0.950 rs13408433 chr2:73883072 G/A cg20560298 chr2:73613845 ALMS1 -0.42 -5.95 -0.31 6.72e-9 Metabolite levels; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg08472276 chr7:1133186 C7orf50;GPER -0.35 -5.8 -0.3 1.56e-8 Longevity;Endometriosis; LUSC cis rs12541635 0.966 rs55729609 chr8:107056034 A/C cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.69e-20 Age of smoking initiation; LUSC cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg08999081 chr20:33150536 PIGU -0.41 -7.56 -0.38 3.88e-13 Glomerular filtration rate (creatinine); LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg00024416 chr22:24240387 NA -0.32 -5.75 -0.3 2.01e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg20243544 chr17:37824526 PNMT 0.39 5.92 0.31 7.93e-9 Self-reported allergy; LUSC cis rs9487051 0.768 rs12176068 chr6:109521629 C/T cg00509249 chr6:109615579 CCDC162 -0.33 -5.79 -0.3 1.66e-8 Reticulocyte fraction of red cells; LUSC cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg03213289 chr20:61660250 NA 0.67 13.26 0.59 1.53e-32 Prostate cancer (SNP x SNP interaction); LUSC cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg07148914 chr20:33460835 GGT7 0.54 8.25 0.41 3.73e-15 Height; LUSC cis rs6012953 0.845 rs2904270 chr20:49185272 G/A cg13958625 chr20:49123093 NA -0.26 -5.72 -0.3 2.37e-8 Vitiligo; LUSC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg03188948 chr7:1209495 NA 0.61 7.02 0.36 1.25e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg24562669 chr7:97807699 LMTK2 -0.39 -6.4 -0.33 5.13e-10 Breast cancer; LUSC cis rs7615952 0.866 rs11922276 chr3:125631326 G/T cg05084668 chr3:125655381 ALG1L -0.78 -11.57 -0.53 2.84e-26 Blood pressure (smoking interaction); LUSC cis rs62458065 1.000 rs10275978 chr7:32466719 G/T cg20159608 chr7:32802032 NA -0.57 -7.01 -0.36 1.34e-11 Metabolite levels (HVA/MHPG ratio); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12495069 chr2:1652362 PXDN 0.4 6.17 0.32 1.95e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs147649347 1 rs147649347 chr2:24210076 GATAA/G cg08917208 chr2:24149416 ATAD2B 0.99 10.48 0.5 2.04e-22 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs672059 0.513 rs627064 chr1:183165716 C/T ch.1.3577855R chr1:183094577 LAMC1 0.45 6.11 0.32 2.78e-9 Hypertriglyceridemia; LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg18402987 chr7:1209562 NA 0.71 7.55 0.38 4.11e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4959270 0.901 rs2316794 chr6:456344 C/T cg09757644 chr6:447497 NA 0.29 6.08 0.32 3.26e-9 Limited cutaneous systemic scleroderma; LUSC cis rs3106136 0.903 rs67552174 chr4:95203097 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.18 -0.32 1.89e-9 Capecitabine sensitivity; LUSC cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg00083206 chr6:110721305 DDO -0.45 -8.28 -0.41 2.95e-15 Platelet distribution width; LUSC cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.43 5.77 0.3 1.82e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs17039065 1.000 rs59671813 chr4:109393618 A/C cg07444054 chr2:108107501 NA 0.41 6.11 0.32 2.74e-9 Gut microbiome composition (summer); LUSC trans rs7613875 0.578 rs2624822 chr3:50107219 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.84 -0.39 6.25e-14 Body mass index; LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg08736216 chr1:53307985 ZYG11A -0.3 -6.1 -0.32 2.92e-9 Monocyte count; LUSC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg17971929 chr21:40555470 PSMG1 0.78 13.72 0.6 2.7e-34 Cognitive function; LUSC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg04414720 chr1:150670196 GOLPH3L 0.5 7.87 0.4 4.84e-14 Melanoma; LUSC cis rs12318506 0.793 rs11180432 chr12:75661314 C/T cg04728562 chr12:75699417 CAPS2 -0.77 -5.93 -0.31 7.49e-9 Coronary artery calcification; LUSC cis rs9394152 0.845 rs9394153 chr6:33471630 A/C cg13560919 chr6:33536144 NA 0.6 10.63 0.5 6.18e-23 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.71 -0.39 1.46e-13 Lymphocyte counts; LUSC cis rs1372520 0.766 rs2583961 chr4:90779758 A/G cg14346243 chr4:90757452 SNCA -0.4 -5.78 -0.3 1.72e-8 Neuroticism; LUSC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg23625390 chr15:77176239 SCAPER 0.46 6.94 0.36 2e-11 Blood metabolite levels; LUSC cis rs6089584 0.927 rs11697597 chr20:60584748 C/T cg06108461 chr20:60628389 TAF4 -0.98 -16.75 -0.68 3.88e-46 Body mass index; LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg25036284 chr2:26402008 FAM59B -0.74 -10.79 -0.51 1.73e-23 Gut microbiome composition (summer); LUSC cis rs4285028 0.948 rs2877560 chr3:121699238 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -9.06 -0.44 1.11e-17 Multiple sclerosis; LUSC trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg20290983 chr6:43655470 MRPS18A -1.04 -23.84 -0.79 4.49e-74 IgG glycosylation; LUSC cis rs17807624 1.000 rs17807624 chr8:11463015 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.95 -0.31 6.73e-9 Systemic lupus erythematosus; LUSC cis rs2425143 1.000 rs6058304 chr20:34299851 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.35 -0.33 6.97e-10 Blood protein levels; LUSC cis rs9790314 0.846 rs4856738 chr3:160986637 C/G cg03342759 chr3:160939853 NMD3 -0.56 -9.52 -0.46 3.56e-19 Morning vs. evening chronotype; LUSC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg15073853 chr19:18549131 ISYNA1 -0.32 -5.87 -0.31 1.04e-8 Breast cancer; LUSC cis rs9463078 0.605 rs10948188 chr6:44926212 G/A cg25276700 chr6:44698697 NA 0.28 5.92 0.31 8.11e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs10789640 0.892 rs11212644 chr11:96574762 G/T cg00988056 chr14:106374554 NA 0.55 5.97 0.31 6.07e-9 Immunoglobulin A vasculitis; LUSC cis rs12210905 0.688 rs9368509 chr6:27379422 A/G cg08851530 chr6:28072375 NA -0.9 -6.37 -0.33 6.1e-10 Hip circumference adjusted for BMI; LUSC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg06671706 chr8:8559999 CLDN23 0.51 6.68 0.34 9.75e-11 Obesity-related traits; LUSC cis rs73206853 0.841 rs3026486 chr12:110782532 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 6.43 0.33 4.37e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs11098499 0.739 rs7441137 chr4:120133221 G/T cg09307838 chr4:120376055 NA -0.6 -8.85 -0.44 5.24e-17 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10144964 chr16:31191008 FUS -0.42 -6.36 -0.33 6.48e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1577917 1.000 rs35761942 chr6:86629504 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.86 -0.44 4.97e-17 Response to antipsychotic treatment; LUSC cis rs2230307 0.536 rs11166384 chr1:100439890 C/T cg24955406 chr1:100503596 HIAT1 0.56 6.04 0.31 4.01e-9 Carotid intima media thickness; LUSC cis rs11155671 0.530 rs2342770 chr6:150216685 C/T cg07701084 chr6:150067640 NUP43 0.43 6.44 0.33 4.08e-10 Testicular germ cell tumor; LUSC cis rs394563 0.602 rs409099 chr6:149766863 T/G cg07828024 chr6:149772892 ZC3H12D -0.33 -7.37 -0.37 1.34e-12 Dupuytren's disease; LUSC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg18350739 chr11:68623251 NA -0.33 -5.88 -0.31 9.72e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.28 6.13 0.32 2.49e-9 Electroencephalogram traits; LUSC cis rs911186 0.730 rs2393911 chr6:27057079 C/T cg12826209 chr6:26865740 GUSBL1 0.67 8.65 0.43 2.22e-16 Autism spectrum disorder or schizophrenia; LUSC trans rs2727020 0.617 rs1917311 chr11:49422665 C/T cg03929089 chr4:120376271 NA -1.01 -17.41 -0.69 9.43e-49 Coronary artery disease; LUSC cis rs17539620 0.624 rs4566892 chr6:154837346 C/T cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg02732134 chr10:101732382 DNMBP -0.36 -6.01 -0.31 4.94e-9 Calcium levels; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg02259775 chr5:98104877 RGMB 0.49 6.54 0.34 2.36e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg15423357 chr2:25149977 NA 0.44 8.98 0.44 1.96e-17 Body mass index; LUSC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.954 rs28685688 chr4:120420334 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg08472276 chr7:1133186 C7orf50;GPER -0.42 -6.81 -0.35 4.53e-11 Longevity;Endometriosis; LUSC cis rs138918 1.000 rs113515 chr22:43556922 C/G cg08909806 chr22:43548696 TSPO 0.37 6.94 0.36 2.04e-11 Monocyte count; LUSC cis rs793571 0.590 rs347115 chr15:59082959 C/T cg05156742 chr15:59063176 FAM63B 0.56 8.59 0.43 3.47e-16 Schizophrenia; LUSC trans rs11039798 0.920 rs7478904 chr11:48630323 C/T cg15704280 chr7:45808275 SEPT13 0.75 6.45 0.33 4.04e-10 Axial length; LUSC cis rs6574644 1.000 rs1957544 chr14:81773268 A/T cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs9486715 1.000 rs9398148 chr6:97063555 A/G cg06623918 chr6:96969491 KIAA0776 -0.86 -14.55 -0.62 1.65e-37 Headache; LUSC cis rs10752881 1.000 rs8179283 chr1:182974602 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.82e-23 Colorectal cancer; LUSC cis rs10159302 0.636 rs267644 chr1:57790529 C/G cg23691223 chr1:57785036 DAB1 -0.37 -5.91 -0.31 8.41e-9 HIV-1 control; LUSC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg04450456 chr4:17643702 FAM184B 0.38 6.48 0.33 3.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6598955 0.670 rs3795685 chr1:26601385 A/G cg04990556 chr1:26633338 UBXN11 0.79 14.57 0.62 1.45e-37 Obesity-related traits; LUSC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg15147215 chr3:52552868 STAB1 -0.31 -6.2 -0.32 1.65e-9 Bipolar disorder; LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg01125463 chr6:42946178 PEX6 -0.37 -6.03 -0.31 4.27e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2011503 0.882 rs10401714 chr19:19363630 G/A cg11244672 chr19:19639970 YJEFN3 -0.54 -6.59 -0.34 1.76e-10 Bipolar disorder; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.33 -0.41 2.17e-15 Lymphocyte counts; LUSC cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg23277830 chr1:3704460 LRRC47 0.35 6.48 0.33 3.3e-10 Red cell distribution width; LUSC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg08847533 chr14:75593920 NEK9 0.84 15.61 0.65 1.25e-41 Height; LUSC cis rs10097731 0.901 rs10464890 chr8:82042727 A/G cg25230327 chr8:82042993 NA -0.48 -6.78 -0.35 5.55e-11 Serum total protein level; LUSC cis rs7647973 0.667 rs9869256 chr3:49624095 T/G cg13072238 chr3:49761600 GMPPB -0.73 -8.34 -0.42 1.94e-15 Menarche (age at onset); LUSC cis rs921968 0.541 rs733925 chr2:219302466 G/A cg02176678 chr2:219576539 TTLL4 -0.72 -13.52 -0.59 1.57e-33 Mean corpuscular hemoglobin concentration; LUSC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18301423 chr5:131593218 PDLIM4 0.47 7.03 0.36 1.15e-11 Acylcarnitine levels; LUSC cis rs611744 0.625 rs6469168 chr8:109288399 G/T cg18478394 chr8:109455254 TTC35 0.44 6.68 0.34 9.86e-11 Dupuytren's disease; LUSC cis rs7267979 0.868 rs6138550 chr20:25223430 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.27 0.71 3.52e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11168618 1.000 rs11168618 chr12:48933233 C/T cg24011408 chr12:48396354 COL2A1 0.41 6.66 0.34 1.11e-10 Adiponectin levels; LUSC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg20203395 chr5:56204925 C5orf35 -0.77 -10.47 -0.5 2.31e-22 Initial pursuit acceleration; LUSC cis rs7818345 0.935 rs7016592 chr8:19277735 A/G cg11303988 chr8:19266685 CSGALNACT1 0.39 7.42 0.38 9.75e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs11997175 0.846 rs7388664 chr8:33768773 T/G ch.8.33884649F chr8:33765107 NA 0.58 9.37 0.46 1.1e-18 Body mass index; LUSC cis rs11098499 0.909 rs11723839 chr4:120299673 G/A cg09307838 chr4:120376055 NA 0.79 11.44 0.53 8.35e-26 Corneal astigmatism; LUSC cis rs477692 0.967 rs496692 chr10:131429100 C/T cg05714579 chr10:131428358 MGMT 0.51 7.57 0.38 3.65e-13 Response to temozolomide; LUSC cis rs7178572 1.000 rs8034133 chr15:77763712 C/G cg22256960 chr15:77711686 NA -0.55 -9.2 -0.45 4.07e-18 Type 2 diabetes; LUSC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg06108461 chr20:60628389 TAF4 -0.97 -16.65 -0.67 9.23e-46 Body mass index; LUSC cis rs9527 0.590 rs10883830 chr10:104851285 G/A cg04362960 chr10:104952993 NT5C2 0.62 9.77 0.47 5.41e-20 Arsenic metabolism; LUSC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg11645453 chr3:52864694 ITIH4 0.34 8.08 0.4 1.23e-14 Electroencephalogram traits; LUSC cis rs8017423 0.967 rs12589808 chr14:90719236 C/T cg04374321 chr14:90722782 PSMC1 -0.7 -10.62 -0.5 6.64e-23 Mortality in heart failure; LUSC cis rs35306767 0.668 rs72760914 chr10:1070952 A/G cg26597838 chr10:835615 NA 0.59 7.71 0.39 1.44e-13 Eosinophil percentage of granulocytes; LUSC cis rs600231 0.706 rs10896016 chr11:65335705 C/T cg17120908 chr11:65337727 SSSCA1 0.57 9.63 0.47 1.59e-19 Bone mineral density; LUSC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg09877947 chr5:131593287 PDLIM4 0.34 5.77 0.3 1.77e-8 Blood metabolite levels; LUSC cis rs1670533 1.000 rs62879260 chr4:1050850 T/C cg16405210 chr4:1374714 KIAA1530 -0.47 -5.8 -0.3 1.57e-8 Recombination rate (females); LUSC cis rs7677751 0.806 rs4864860 chr4:55090021 T/C cg17187183 chr4:55093834 PDGFRA 0.38 5.83 0.3 1.3e-8 Corneal astigmatism; LUSC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg12386194 chr3:101231763 SENP7 0.64 8.96 0.44 2.36e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs4803468 0.967 rs1077856 chr19:41885221 T/C cg09537434 chr19:41945824 ATP5SL -0.87 -15.12 -0.64 1.01e-39 Height; LUSC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg21433313 chr16:3507492 NAT15 -0.81 -9.04 -0.44 1.28e-17 Tuberculosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24501027 chr1:92764777 RPAP2;GLMN -0.43 -6.6 -0.34 1.62e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.55 -0.34 2.11e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg00522288 chr12:125625016 AACS -0.3 -5.77 -0.3 1.79e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6545883 0.929 rs10200055 chr2:61628017 T/A cg15711740 chr2:61764176 XPO1 0.43 6.54 0.34 2.25e-10 Tuberculosis; LUSC cis rs16854884 0.586 rs7642551 chr3:143732167 C/T cg06585982 chr3:143692056 C3orf58 0.52 8.34 0.42 1.91e-15 Economic and political preferences (feminism/equality); LUSC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18099408 chr3:52552593 STAB1 -0.42 -7.33 -0.37 1.78e-12 Bipolar disorder; LUSC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs6084875 0.812 rs2093386 chr20:4724313 A/G cg26097573 chr20:4721490 PRNT -0.31 -5.78 -0.3 1.76e-8 Systemic lupus erythematosus; LUSC cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg08999081 chr20:33150536 PIGU 0.55 10.97 0.51 4.18e-24 Coronary artery disease; LUSC trans rs4714291 0.792 rs9471241 chr6:40080211 C/T cg02267698 chr19:7991119 CTXN1 -0.57 -8.66 -0.43 2.01e-16 Strep throat; LUSC cis rs11209002 0.567 rs983110 chr1:67539215 A/T cg02640540 chr1:67518911 SLC35D1 0.62 8.53 0.42 5.27e-16 Crohn's disease; LUSC cis rs7100689 0.646 rs7894762 chr10:82086779 C/G cg01528321 chr10:82214614 TSPAN14 0.82 12.33 0.56 4.69e-29 Post bronchodilator FEV1; LUSC cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg20503657 chr10:835505 NA -0.51 -6.94 -0.36 2.03e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs1322512 0.917 rs1727050 chr6:152944716 C/G cg27316956 chr6:152958899 SYNE1 -0.36 -6.03 -0.31 4.46e-9 Tonometry; LUSC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.01e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs11051970 0.659 rs950081 chr12:32588488 T/G cg02745156 chr12:32552066 NA 0.37 5.82 0.3 1.37e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg03388025 chr16:89894329 SPIRE2 0.33 6.84 0.35 3.79e-11 Vitiligo; LUSC cis rs7799006 0.657 rs10447540 chr7:2301484 A/G cg08027265 chr7:2291960 NA -0.63 -11.23 -0.52 4.8e-25 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.97 0.31 5.99e-9 Tonsillectomy; LUSC cis rs7223966 1.000 rs8075273 chr17:61728881 G/T cg11494091 chr17:61959527 GH2 0.46 6.93 0.35 2.22e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10504073 0.565 rs974780 chr8:49930976 G/A cg00325661 chr8:49890786 NA 0.7 11.06 0.52 1.95e-24 Blood metabolite ratios; LUSC cis rs3820068 0.544 rs7551750 chr1:16035008 T/C cg24675056 chr1:15929824 NA 0.4 6.58 0.34 1.87e-10 Systolic blood pressure; LUSC trans rs2679649 1.000 rs2684263 chr6:122366184 T/C cg10483660 chr13:112241077 NA 0.69 6.14 0.32 2.31e-9 Subcutaneous adipose tissue; LUSC cis rs754466 0.958 rs58916802 chr10:79695870 G/A cg17075019 chr10:79541650 NA -0.63 -8.01 -0.4 1.92e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg26528668 chr16:1614120 IFT140 0.43 7.22 0.37 3.51e-12 Coronary artery disease; LUSC cis rs909341 0.710 rs6011016 chr20:62302650 C/G cg09650180 chr20:62225654 GMEB2 0.45 5.8 0.3 1.57e-8 Atopic dermatitis; LUSC cis rs472402 0.560 rs10065299 chr5:6654489 T/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.45 -6.54 -0.34 2.24e-10 Response to amphetamines; LUSC cis rs17818399 0.547 rs12997164 chr2:46758746 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.53 -6.96 -0.36 1.78e-11 Height; LUSC cis rs3126085 0.935 rs11204939 chr1:152200942 G/C cg26876637 chr1:152193138 HRNR 0.45 6.41 0.33 4.93e-10 Atopic dermatitis; LUSC cis rs11785400 1.000 rs7002932 chr8:143738816 C/A cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg03233332 chr7:66118400 NA -0.42 -6.18 -0.32 1.91e-9 Aortic root size; LUSC cis rs9457247 0.565 rs12193698 chr6:167512073 C/A cg07741184 chr6:167504864 NA 0.51 8.73 0.43 1.2e-16 Crohn's disease; LUSC cis rs11677416 1.000 rs72825514 chr2:113527706 G/T cg27083787 chr2:113543245 IL1A 0.47 7.27 0.37 2.64e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.75 -12.71 -0.57 1.82e-30 Total body bone mineral density; LUSC cis rs6977660 1.000 rs13230910 chr7:19806003 A/G cg05791153 chr7:19748676 TWISTNB -0.55 -6.1 -0.32 3.02e-9 Thyroid stimulating hormone; LUSC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg21972741 chr5:435613 AHRR 0.37 6.99 0.36 1.47e-11 Cystic fibrosis severity; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.29 -0.33 9.82e-10 Bipolar disorder and schizophrenia; LUSC cis rs3771570 1.000 rs59496049 chr2:242260756 G/C cg21155796 chr2:242212141 HDLBP 0.58 6.51 0.34 2.69e-10 Prostate cancer; LUSC cis rs6500602 0.702 rs11645519 chr16:4538989 G/A cg08645402 chr16:4508243 NA 0.5 8.55 0.42 4.56e-16 Schizophrenia; LUSC cis rs765787 0.530 rs28815867 chr15:45526805 G/C cg24006582 chr15:45444508 DUOX1 -0.61 -9.03 -0.44 1.43e-17 Uric acid levels; LUSC cis rs11676348 0.904 rs10804264 chr2:218955809 T/C cg06547715 chr2:218990976 CXCR2 0.3 5.72 0.3 2.34e-8 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03637614 chr7:129691233 ZC3HC1 0.48 7.43 0.38 9.24e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11626933 0.959 rs17799226 chr14:90754538 C/T cg14092571 chr14:90743983 NA -0.88 -18.24 -0.71 4.54e-52 Gut microbiota (bacterial taxa); LUSC cis rs68170813 0.605 rs74632724 chr7:107136759 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.44 -5.92 -0.31 7.91e-9 Coronary artery disease; LUSC cis rs2228479 0.681 rs7196840 chr16:89959647 A/G cg00800038 chr16:89945340 TCF25 -0.63 -6.68 -0.34 1.02e-10 Skin colour saturation; LUSC cis rs4820539 0.902 rs4822359 chr22:23474972 A/G cg21100191 chr22:23484243 RTDR1 0.92 16.15 0.66 8.97e-44 Bone mineral density; LUSC cis rs7640424 0.826 rs7635063 chr3:107818777 C/T cg09227934 chr3:107805635 CD47 -0.55 -9.0 -0.44 1.77e-17 Body mass index; LUSC cis rs760805 0.900 rs1005733 chr1:25261960 T/A cg22509179 chr1:25234806 RUNX3 -0.61 -10.02 -0.48 7.98e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg12365402 chr11:9010492 NRIP3 0.45 8.26 0.41 3.33e-15 Hemoglobin concentration; LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg19318889 chr4:1322082 MAEA 0.47 7.54 0.38 4.62e-13 Obesity-related traits; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg24739457 chr1:205821442 NA -0.34 -5.87 -0.31 1.04e-8 Menarche (age at onset); LUSC cis rs9549367 0.789 rs12584981 chr13:113881185 T/C cg00898013 chr13:113819073 PROZ -0.56 -7.91 -0.4 3.93e-14 Platelet distribution width; LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg27094323 chr7:1216898 NA -0.46 -8.02 -0.4 1.85e-14 Longevity;Endometriosis; LUSC cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg18132916 chr6:79620363 NA -0.38 -5.8 -0.3 1.56e-8 Intelligence (multi-trait analysis); LUSC cis rs9612 1.000 rs12669 chr19:44235535 G/A cg08581076 chr19:44259116 C19orf61 0.52 6.36 0.33 6.53e-10 Exhaled nitric oxide output; LUSC cis rs4237845 0.967 rs4553410 chr12:58301211 G/A cg00677455 chr12:58241039 CTDSP2 0.49 7.35 0.37 1.54e-12 Intelligence (multi-trait analysis); LUSC trans rs45509595 0.841 rs9368531 chr6:27781872 G/C cg06606381 chr12:133084897 FBRSL1 -0.74 -7.4 -0.38 1.1e-12 Breast cancer; LUSC cis rs6066835 1.000 rs6122720 chr20:47351095 G/A cg18078177 chr20:47281410 PREX1 0.71 6.21 0.32 1.61e-9 Multiple myeloma; LUSC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs11779988 0.629 rs7465361 chr8:17854155 T/C cg01800426 chr8:17659068 MTUS1 -0.51 -6.62 -0.34 1.47e-10 Breast cancer; LUSC cis rs6121246 0.567 rs6087700 chr20:30217560 A/G cg13852791 chr20:30311386 BCL2L1 0.77 8.73 0.43 1.25e-16 Mean corpuscular hemoglobin; LUSC cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg04455712 chr21:45112962 RRP1B 0.44 8.5 0.42 6.39e-16 Mean corpuscular volume; LUSC cis rs11190604 1.000 rs79831012 chr10:102237059 T/C cg16342193 chr10:102329863 NA -0.35 -6.24 -0.32 1.32e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7809950 1.000 rs10258385 chr7:107243350 T/C cg23024343 chr7:107201750 COG5 0.57 8.97 0.44 2.14e-17 Coronary artery disease; LUSC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg18876405 chr7:65276391 NA 0.54 8.27 0.41 3.22e-15 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09225691 chr3:98312547 CPOX -0.43 -6.45 -0.33 3.85e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg06784218 chr1:46089804 CCDC17 0.48 9.39 0.46 9.53e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7666738 0.546 rs10440329 chr4:98903735 C/T cg17366294 chr4:99064904 C4orf37 0.52 8.48 0.42 7.21e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg22823121 chr1:150693482 HORMAD1 0.47 7.01 0.36 1.3e-11 Melanoma; LUSC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.85 0.47 3e-20 Personality dimensions; LUSC cis rs79387448 0.505 rs17027327 chr2:103122513 C/A cg09003973 chr2:102972529 NA 0.87 8.56 0.42 4.28e-16 Gut microbiota (bacterial taxa); LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg08888203 chr3:10149979 C3orf24 0.64 8.61 0.43 2.97e-16 Alzheimer's disease; LUSC cis rs7180079 1.000 rs7177457 chr15:64530839 C/T cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg05347473 chr6:146136440 FBXO30 0.48 7.89 0.4 4.3e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs847577 0.630 rs13221758 chr7:97719806 A/C cg21770322 chr7:97807741 LMTK2 0.56 9.94 0.48 1.4e-20 Breast cancer; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg16325326 chr1:53192061 ZYG11B 0.81 14.4 0.62 6.33e-37 Monocyte count; LUSC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg17971929 chr21:40555470 PSMG1 0.79 13.58 0.6 9.75e-34 Cognitive function; LUSC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.14 0.64 8.69e-40 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg16145915 chr7:1198662 ZFAND2A -0.52 -10.15 -0.49 2.82e-21 Longevity;Endometriosis; LUSC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11890956 chr21:40555474 PSMG1 0.92 17.02 0.68 3.35e-47 Cognitive function; LUSC cis rs11229555 0.645 rs12295551 chr11:58188983 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg23711669 chr6:146136114 FBXO30 0.92 17.86 0.7 1.54e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs4144027 0.869 rs55924227 chr14:104361350 G/C cg12183467 chr14:104352244 NA 0.29 5.71 0.3 2.47e-8 Blood metabolite levels; LUSC cis rs3768617 0.510 rs10752896 chr1:183068516 A/C ch.1.3577855R chr1:183094577 LAMC1 0.72 10.87 0.51 9.49e-24 Fuchs's corneal dystrophy; LUSC trans rs61931739 0.500 rs11053207 chr12:34459827 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.87e-34 Morning vs. evening chronotype; LUSC cis rs3008870 0.755 rs2208577 chr1:67513574 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.66 9.85 0.47 2.98e-20 Lymphocyte percentage of white cells; LUSC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg10018233 chr7:150070692 REPIN1 0.41 6.79 0.35 5.24e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg25036284 chr2:26402008 FAM59B -0.72 -10.45 -0.5 2.69e-22 Gut microbiome composition (summer); LUSC cis rs1113500 0.933 rs2077259 chr1:108629551 T/C cg06207961 chr1:108661230 NA 0.4 7.45 0.38 8.2e-13 Growth-regulated protein alpha levels; LUSC cis rs35995292 0.534 rs7793692 chr7:38940580 G/C cg19327137 chr7:38886074 VPS41 0.54 10.18 0.49 2.18e-21 Subjective well-being (multi-trait analysis); LUSC cis rs9788682 0.747 rs12910984 chr15:78891627 G/A cg06917634 chr15:78832804 PSMA4 0.53 6.71 0.34 8.11e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6987853 0.761 rs2974321 chr8:42424727 A/G cg09913449 chr8:42400586 C8orf40 0.53 9.16 0.45 5.49e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs778371 0.624 rs6733495 chr2:233616709 A/G cg08000102 chr2:233561755 GIGYF2 0.81 13.92 0.61 4.9e-35 Schizophrenia; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg03354898 chr7:1950403 MAD1L1 -0.42 -8.43 -0.42 1.05e-15 Bipolar disorder and schizophrenia; LUSC cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg20283391 chr11:68216788 NA -0.59 -8.31 -0.41 2.46e-15 Total body bone mineral density; LUSC cis rs4728302 0.583 rs1424583 chr7:133159583 T/G cg10665199 chr7:133106180 EXOC4 0.58 8.16 0.41 6.67e-15 Intelligence;Intelligence (multi-trait analysis); LUSC cis rs7572644 0.766 rs13029008 chr2:28212890 A/G cg27432699 chr2:27873401 GPN1 0.52 6.33 0.33 7.86e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg18105134 chr13:113819100 PROZ -0.66 -9.53 -0.46 3.35e-19 Platelet distribution width; LUSC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.77 -12.69 -0.57 2.21e-30 Hip circumference adjusted for BMI; LUSC trans rs11700980 0.551 rs909329 chr21:30108262 G/A cg14791747 chr16:20752902 THUMPD1 0.56 6.16 0.32 2.1e-9 QRS complex (12-leadsum); LUSC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs4363385 0.693 rs6690549 chr1:152930426 C/T cg07796016 chr1:152779584 LCE1C -0.46 -6.54 -0.34 2.3e-10 Inflammatory skin disease; LUSC trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg15704280 chr7:45808275 SEPT13 0.73 8.39 0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg17986701 chr20:44574422 PCIF1 -0.4 -7.1 -0.36 7.6e-12 Intelligence (multi-trait analysis); LUSC cis rs9486715 1.000 rs9373985 chr6:97063522 C/G cg06623918 chr6:96969491 KIAA0776 -0.86 -14.55 -0.62 1.65e-37 Headache; LUSC cis rs3808502 0.574 rs4841559 chr8:11416885 C/T cg21175976 chr8:11421337 BLK -0.35 -5.7 -0.3 2.68e-8 Neuroticism; LUSC cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -12.01 -0.55 7.22e-28 Hemoglobin concentration; LUSC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg12963246 chr6:28129442 ZNF389 0.4 6.37 0.33 6.29e-10 Parkinson's disease; LUSC cis rs1559088 0.847 rs2287679 chr19:33600764 T/C cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.03e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg18876405 chr7:65276391 NA -0.74 -13.35 -0.59 7.01e-33 Aortic root size; LUSC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg04518342 chr5:131593106 PDLIM4 0.37 7.03 0.36 1.2e-11 Blood metabolite levels; LUSC cis rs9815354 0.680 rs73073280 chr3:42025772 T/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs483180 0.512 rs677277 chr1:120202298 C/T cg19096424 chr1:120255104 PHGDH -0.49 -6.59 -0.34 1.72e-10 Macular telangiectasia type 2; LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg22166914 chr1:53195759 ZYG11B 0.48 7.61 0.38 2.74e-13 Monocyte count; LUSC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg20607287 chr7:12443886 VWDE -0.59 -6.2 -0.32 1.71e-9 Coronary artery disease; LUSC cis rs11758351 0.866 rs2069019 chr6:26205604 C/T cg23601095 chr6:26197514 HIST1H3D 0.72 7.7 0.39 1.51e-13 Gout;Renal underexcretion gout; LUSC cis rs10782582 0.593 rs6675076 chr1:76118503 A/C cg22875332 chr1:76189707 ACADM -0.42 -6.45 -0.33 3.83e-10 Daytime sleep phenotypes; LUSC cis rs4268898 0.931 rs34504814 chr2:24503766 C/T cg06627628 chr2:24431161 ITSN2 -0.62 -9.29 -0.45 1.97e-18 Asthma; LUSC cis rs2303282 0.716 rs1382359 chr16:56399514 G/A cg00500540 chr16:56394104 NA -0.44 -7.59 -0.38 3.27e-13 Breast cancer; LUSC cis rs9388451 0.839 rs3799711 chr6:126075313 C/T cg05901451 chr6:126070800 HEY2 0.95 18.85 0.72 1.65e-54 Brugada syndrome; LUSC cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg18404041 chr3:52824283 ITIH1 -0.57 -9.65 -0.47 1.31e-19 Schizophrenia; LUSC trans rs7726839 0.540 rs11739847 chr5:609661 G/A cg25482853 chr8:67687455 SGK3 1.12 15.79 0.65 2.41e-42 Obesity-related traits; LUSC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.49e-11 Schizophrenia; LUSC trans rs1459104 0.866 rs28873990 chr11:54812748 G/A cg15704280 chr7:45808275 SEPT13 0.75 6.55 0.34 2.23e-10 Body mass index; LUSC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.81 -12.44 -0.56 1.91e-29 Cognitive test performance; LUSC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.933 rs2387887 chr20:25427081 G/T cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg08213375 chr14:104286397 PPP1R13B -0.53 -10.13 -0.48 3.33e-21 Schizophrenia; LUSC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg08270630 chr22:50330655 NA 0.41 6.05 0.31 3.98e-9 Schizophrenia; LUSC trans rs12579753 1.000 rs7975863 chr12:82227288 C/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs2014572 0.967 rs8100154 chr19:57765432 A/G cg24459738 chr19:57751996 ZNF805 -0.5 -7.51 -0.38 5.32e-13 Hyperactive-impulsive symptoms; LUSC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg12311346 chr5:56204834 C5orf35 0.5 7.57 0.38 3.64e-13 Coronary artery disease; LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg22907277 chr7:1156413 C7orf50 0.72 7.67 0.39 1.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg23791538 chr6:167370224 RNASET2 0.41 6.7 0.34 8.84e-11 Crohn's disease; LUSC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg18827107 chr12:86230957 RASSF9 0.45 6.86 0.35 3.4e-11 Major depressive disorder; LUSC cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg03060546 chr3:49711283 APEH -0.69 -10.12 -0.48 3.6e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6961069 0.901 rs819436 chr7:80224314 C/T cg04458919 chr7:80252533 CD36 -0.32 -5.9 -0.31 8.95e-9 Platelet count; LUSC trans rs9944275 0.799 rs12916235 chr15:97192412 G/A cg18834029 chr10:103349097 POLL;RP11-529I10.4 -0.6 -5.97 -0.31 6.23e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); LUSC trans rs10221833 0.602 rs355893 chr2:165635147 A/G cg26993132 chr16:89239499 CDH15 0.31 5.99 0.31 5.47e-9 Response to statin therapy; LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg03146154 chr1:46216737 IPP 0.52 7.67 0.39 1.9e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4500972 1 rs4500972 chr2:73767897 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.57 -0.34 1.94e-10 Glomerular filtration rate (creatinine); LUSC cis rs7508679 1.000 rs10401485 chr19:7222234 T/C cg09779027 chr19:7224513 INSR 0.44 9.55 0.46 2.98e-19 Hypothyroidism; LUSC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg17848003 chr1:3704513 LRRC47 0.33 6.2 0.32 1.65e-9 Red cell distribution width; LUSC cis rs7020830 0.931 rs6476613 chr9:37084340 A/G cg14294708 chr9:37120828 ZCCHC7 1.08 23.5 0.79 9.18e-73 Schizophrenia; LUSC cis rs9640161 0.830 rs11972067 chr7:150071605 G/A cg21361702 chr7:150065534 REPIN1 0.59 9.18 0.45 4.49e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg08219700 chr8:58056026 NA 0.69 7.85 0.39 5.69e-14 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.502 rs1589390 chr12:38416139 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.65 -0.34 1.18e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg16235748 chr6:149772707 ZC3H12D -0.28 -5.66 -0.3 3.26e-8 Dupuytren's disease; LUSC cis rs4919687 0.550 rs12783444 chr10:104480659 G/A cg04362960 chr10:104952993 NT5C2 0.45 6.47 0.33 3.56e-10 Colorectal cancer; LUSC cis rs7824557 0.564 rs6601584 chr8:11232343 C/G cg21775007 chr8:11205619 TDH -0.67 -10.73 -0.51 2.83e-23 Retinal vascular caliber; LUSC cis rs2839186 0.739 rs7282763 chr21:47696800 C/T cg12379764 chr21:47803548 PCNT -0.42 -5.91 -0.31 8.39e-9 Testicular germ cell tumor; LUSC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.57 10.11 0.48 3.82e-21 Bipolar disorder; LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.26 0.45 2.6e-18 Prudent dietary pattern; LUSC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg15744005 chr10:104629667 AS3MT -0.28 -5.9 -0.31 8.88e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12594515 0.967 rs12595138 chr15:45986108 G/C cg01629716 chr15:45996671 NA 0.4 5.87 0.31 1.05e-8 Waist circumference;Weight; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg12237616 chr13:21678564 NA -0.42 -6.68 -0.34 9.96e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs7220711 0.902 rs4793019 chr17:41781160 A/C cg26893861 chr17:41843967 DUSP3 -0.44 -6.13 -0.32 2.54e-9 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 10.91 0.51 6.61e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs28595532 0.748 rs113336496 chr4:119336957 C/T cg21605333 chr4:119757512 SEC24D 0.95 7.97 0.4 2.46e-14 Cannabis dependence symptom count; LUSC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg08677398 chr8:58056175 NA 0.53 6.36 0.33 6.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs7520050 0.778 rs3014238 chr1:46090214 A/G cg24296786 chr1:45957014 TESK2 0.42 5.89 0.31 9.46e-9 Red blood cell count;Reticulocyte count; LUSC cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC cis rs250677 1.000 rs28173 chr5:148423573 C/T cg18129178 chr5:148520854 ABLIM3 -0.67 -10.81 -0.51 1.49e-23 Breast cancer; LUSC cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg21535247 chr6:8435926 SLC35B3 0.6 9.27 0.45 2.37e-18 Motion sickness; LUSC cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg12573674 chr2:1569213 NA -0.55 -7.76 -0.39 1.08e-13 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.08 0.36 8.3e-12 Major depressive disorder; LUSC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.31e-10 Height; LUSC cis rs2070997 0.607 rs3808821 chr9:133712801 G/T cg11464064 chr9:133710261 ABL1 -0.46 -5.84 -0.3 1.21e-8 Response to amphetamines; LUSC cis rs3931020 0.688 rs405445 chr1:75221150 C/T cg26855724 chr1:75198818 TYW3;CRYZ -0.46 -5.92 -0.31 8.06e-9 Resistin levels; LUSC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.83 -0.81 7.74e-78 Height; LUSC cis rs2840044 1.000 rs1671656 chr17:33939661 C/T cg05299278 chr17:33885742 SLFN14 0.3 6.23 0.32 1.38e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs4954585 0.683 rs13024450 chr2:137014611 C/T cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.79e-13 Colorectal cancer; LUSC cis rs8032315 0.895 rs4932370 chr15:91404705 A/G cg04510874 chr15:91427884 FES -0.32 -6.65 -0.34 1.21e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13012494 chr21:47604986 C21orf56 -0.47 -7.01 -0.36 1.35e-11 Testicular germ cell tumor; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T ch.9.2051689R chr9:128344852 MAPKAP1 -0.46 -6.07 -0.32 3.42e-9 Hepatitis; LUSC cis rs951366 0.576 rs11240561 chr1:205712957 T/G cg11965913 chr1:205819406 PM20D1 -0.49 -6.73 -0.35 7.57e-11 Menarche (age at onset); LUSC cis rs17092148 0.887 rs6059916 chr20:33148861 T/G cg16810054 chr20:33298113 TP53INP2 -0.35 -5.66 -0.3 3.26e-8 Neuroticism; LUSC cis rs4964805 0.594 rs3812805 chr12:104170872 C/T cg02344784 chr12:104178138 NT5DC3 0.36 5.83 0.3 1.31e-8 Attention deficit hyperactivity disorder; LUSC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.21 -0.49 1.74e-21 Allergic disease (asthma, hay fever or eczema); LUSC trans rs1015291 0.748 rs941233 chr12:19993676 C/T cg01501474 chr7:55323552 NA 0.46 6.03 0.31 4.36e-9 Diastolic blood pressure; LUSC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg11764359 chr7:65958608 NA -0.67 -10.74 -0.51 2.67e-23 Aortic root size; LUSC cis rs7113850 0.541 rs80243979 chr11:24231811 A/C ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Bone fracture in osteoporosis; LUSC cis rs929596 0.563 rs1105879 chr2:234602202 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.22 -0.37 3.62e-12 Total bilirubin levels in HIV-1 infection; LUSC cis rs240768 0.826 rs240779 chr6:100963633 T/A cg12253828 chr6:101329408 ASCC3 0.78 5.69 0.3 2.72e-8 Economic and political preferences (immigration/crime); LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg18538332 chr22:24372958 LOC391322 -0.49 -8.87 -0.44 4.48e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs861020 0.630 rs686582 chr1:210008673 A/C cg05527609 chr1:210001259 C1orf107 0.67 9.75 0.47 6.24e-20 Orofacial clefts; LUSC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg16928487 chr17:17741425 SREBF1 0.47 9.32 0.45 1.66e-18 Total body bone mineral density; LUSC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.84 0.3 1.27e-8 Intelligence (multi-trait analysis); LUSC cis rs3733418 0.929 rs12512234 chr4:165908865 C/T cg08992305 chr4:165878219 TRIM61;C4orf39 -0.51 -5.92 -0.31 8.03e-9 Obesity-related traits; LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg13047869 chr3:10149882 C3orf24 0.6 8.52 0.42 5.73e-16 Alzheimer's disease; LUSC cis rs9733 0.744 rs11204737 chr1:150847647 C/T cg04414720 chr1:150670196 GOLPH3L -0.44 -6.91 -0.35 2.43e-11 Tonsillectomy; LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.48 7.17 0.37 4.92e-12 Prudent dietary pattern; LUSC cis rs868036 1.000 rs4776377 chr15:68103387 T/C cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs2235649 0.703 rs2076428 chr16:1817768 T/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 0.47 5.92 0.31 8.04e-9 Blood metabolite levels; LUSC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg01802117 chr1:53393560 SCP2 -0.36 -5.81 -0.3 1.47e-8 Monocyte count; LUSC cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg08045932 chr20:61659980 NA 0.43 6.34 0.33 7.56e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1950626 0.750 rs34144313 chr14:101431216 C/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.75 0.39 1.08e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg15997130 chr1:24165203 NA -0.46 -6.6 -0.34 1.57e-10 Immature fraction of reticulocytes; LUSC cis rs13256369 0.802 rs2280560 chr8:8560602 C/T cg00074818 chr8:8560427 CLDN23 0.59 9.59 0.46 2.12e-19 Obesity-related traits; LUSC cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg26587870 chr6:27730563 NA -0.61 -5.79 -0.3 1.62e-8 Breast cancer; LUSC trans rs890100 0.867 rs11900485 chr2:56740189 C/A cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.31 -6.07 -0.32 3.42e-9 Gut microbiome composition (summer); LUSC cis rs7605827 0.893 rs7589238 chr2:15606409 C/A cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10904908 0.862 rs359281 chr10:17320144 A/G cg01003015 chr10:17271136 VIM 0.43 6.32 0.33 8.43e-10 Total cholesterol levels;Cholesterol, total; LUSC cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg24642439 chr20:33292090 TP53INP2 0.75 12.41 0.56 2.45e-29 Coronary artery disease; LUSC trans rs61931739 0.500 rs7307583 chr12:34521711 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.19e-33 Morning vs. evening chronotype; LUSC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg21665744 chr7:39171113 POU6F2 0.46 7.44 0.38 8.61e-13 IgG glycosylation; LUSC trans rs1973993 0.708 rs6593605 chr1:96956775 A/G cg10631902 chr5:14652156 NA -0.46 -6.82 -0.35 4.18e-11 Weight; LUSC trans rs724744 0.772 rs1772082 chr6:22354566 T/C cg13807341 chr11:118445984 ARCN1 -0.36 -6.1 -0.32 2.86e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7917772 0.604 rs4917977 chr10:104363119 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 11.03 0.52 2.51e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs72949976 1.000 rs62186569 chr2:214034151 C/T cg08319019 chr2:214017104 IKZF2 -0.62 -9.61 -0.47 1.87e-19 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg03233332 chr7:66118400 NA -0.42 -6.09 -0.32 3.02e-9 Aortic root size; LUSC cis rs7937682 0.737 rs682239 chr11:111425105 A/G cg09085632 chr11:111637200 PPP2R1B 0.58 7.81 0.39 7.43e-14 Primary sclerosing cholangitis; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg08888203 chr3:10149979 C3orf24 -0.56 -8.11 -0.41 9.84e-15 Alzheimer's disease; LUSC trans rs72674100 1.000 rs17026382 chr4:97995366 A/G cg00855990 chr1:18959354 PAX7 -0.58 -6.2 -0.32 1.63e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2070488 0.775 rs7374458 chr3:38531211 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 12.43 0.56 2.14e-29 Electrocardiographic conduction measures; LUSC cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg12011299 chr4:100065546 ADH4 0.73 12.13 0.55 2.69e-28 Alcohol dependence; LUSC trans rs9329221 0.905 rs17709397 chr8:10249861 G/A cg15556689 chr8:8085844 FLJ10661 -0.62 -9.56 -0.46 2.71e-19 Neuroticism; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg09033563 chr22:24373618 LOC391322 0.48 6.71 0.34 8.15e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.09 -0.48 4.66e-21 Developmental language disorder (linguistic errors); LUSC trans rs7937682 0.575 rs7124696 chr11:111747297 A/G cg18187862 chr3:45730750 SACM1L -0.51 -6.18 -0.32 1.83e-9 Primary sclerosing cholangitis; LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg27535305 chr1:53392650 SCP2 -0.39 -7.32 -0.37 1.85e-12 Monocyte count; LUSC cis rs9326248 0.768 rs4936366 chr11:117026885 G/A cg11861562 chr11:117069780 TAGLN 0.35 5.65 0.3 3.4e-8 Blood protein levels; LUSC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg19812747 chr11:111475976 SIK2 -0.57 -8.23 -0.41 4.18e-15 Primary sclerosing cholangitis; LUSC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg17143192 chr8:8559678 CLDN23 0.66 9.15 0.45 5.77e-18 Obesity-related traits; LUSC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg20203395 chr5:56204925 C5orf35 -0.47 -6.85 -0.35 3.49e-11 Coronary artery disease; LUSC trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg27661571 chr11:113659931 NA 0.6 6.25 0.32 1.26e-9 Hip circumference adjusted for BMI; LUSC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.59 -0.38 3.15e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg13047869 chr3:10149882 C3orf24 0.56 7.88 0.4 4.76e-14 Alzheimer's disease; LUSC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg18876405 chr7:65276391 NA -0.56 -8.88 -0.44 4.07e-17 Aortic root size; LUSC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg15649852 chr7:65879115 NA -0.41 -5.81 -0.3 1.49e-8 Aortic root size; LUSC cis rs7267979 1.000 rs2258769 chr20:25276680 G/C cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6964587 0.743 rs33993294 chr7:91998655 A/C cg17063962 chr7:91808500 NA 0.53 7.81 0.39 7.36e-14 Breast cancer; LUSC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.6 0.46 2.01e-19 Mean platelet volume; LUSC cis rs9549367 0.789 rs34989271 chr13:113894766 G/A cg00898013 chr13:113819073 PROZ -0.57 -8.23 -0.41 4.12e-15 Platelet distribution width; LUSC cis rs9660992 0.674 rs17345837 chr1:205263122 C/T cg00857998 chr1:205179979 DSTYK 0.55 8.34 0.42 1.99e-15 Mean corpuscular volume;Mean platelet volume; LUSC trans rs12210905 1.000 rs1062834 chr6:27222539 A/G cg11837749 chr1:55047332 ACOT11 0.58 5.98 0.31 5.64e-9 Hip circumference adjusted for BMI; LUSC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg24110177 chr3:50126178 RBM5 0.65 11.48 0.53 6.07e-26 Body mass index; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg10150615 chr22:24372951 LOC391322 -0.41 -6.85 -0.35 3.52e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11098499 0.739 rs951570 chr4:120150467 T/C cg09307838 chr4:120376055 NA -0.59 -8.8 -0.43 7.49e-17 Corneal astigmatism; LUSC cis rs61931739 0.534 rs1352206 chr12:34036668 G/A cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.05e-15 Morning vs. evening chronotype; LUSC cis rs10088262 0.629 rs7015861 chr8:124795613 C/T cg20713898 chr8:124780851 FAM91A1 -0.54 -7.67 -0.39 1.87e-13 Pancreatic cancer; LUSC cis rs28655083 1.000 rs11863397 chr16:77060388 T/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.42 -6.26 -0.32 1.16e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.641 rs75796305 chr16:68208791 A/G cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs9314323 0.964 rs2304300 chr8:26249018 G/A cg11498726 chr8:26250323 BNIP3L -0.46 -6.8 -0.35 4.69e-11 Red cell distribution width; LUSC cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.73 11.34 0.53 1.95e-25 Colorectal cancer; LUSC cis rs62400317 0.859 rs28583363 chr6:45231336 T/A cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg25809561 chr17:30822961 MYO1D 0.55 9.72 0.47 7.91e-20 Schizophrenia; LUSC trans rs12571093 0.803 rs61854825 chr10:70031292 G/A cg04882175 chr6:131122610 NA -0.55 -6.27 -0.32 1.09e-9 Optic nerve measurement (disc area); LUSC cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg18904891 chr8:8559673 CLDN23 0.38 5.89 0.31 9.52e-9 Mood instability; LUSC cis rs1595825 0.891 rs77029420 chr2:198651492 G/A cg00982548 chr2:198649783 BOLL -0.56 -6.58 -0.34 1.78e-10 Ulcerative colitis; LUSC cis rs4356932 0.811 rs68156651 chr4:76972468 T/C cg00809888 chr4:76862425 NAAA 0.35 5.86 0.31 1.11e-8 Blood protein levels; LUSC cis rs10792830 0.707 rs613222 chr11:85769105 T/G cg07180834 chr11:85838833 NA -0.32 -6.04 -0.31 4.07e-9 Psychosis and Alzheimer's disease; LUSC cis rs10782582 0.586 rs1796813 chr1:76400403 G/A cg10523679 chr1:76189770 ACADM -0.43 -6.28 -0.33 1.04e-9 Daytime sleep phenotypes; LUSC cis rs6665290 0.935 rs17600669 chr1:227201871 A/G cg10327440 chr1:227177885 CDC42BPA -1.2 -35.46 -0.89 2.79e-115 Myeloid white cell count; LUSC cis rs10876993 0.928 rs1678532 chr12:58055197 T/G cg15848620 chr12:58087721 OS9 -0.53 -7.63 -0.39 2.45e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.48 7.04 0.36 1.1e-11 Schizophrenia; LUSC cis rs8072100 0.651 rs1912484 chr17:45443664 C/G cg08085267 chr17:45401833 C17orf57 -0.51 -7.18 -0.37 4.58e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.66 -0.3 3.31e-8 Life satisfaction; LUSC cis rs4363385 0.747 rs6704105 chr1:152964397 C/G cg00922841 chr1:152955080 SPRR1A -0.43 -7.76 -0.39 1.08e-13 Inflammatory skin disease; LUSC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.27e-8 Aortic root size; LUSC cis rs877282 0.945 rs11253388 chr10:787852 A/G cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs4776059 1.000 rs12902679 chr15:52881317 C/T cg22715398 chr15:52968154 KIAA1370 0.73 10.25 0.49 1.27e-21 Schizophrenia; LUSC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg18827107 chr12:86230957 RASSF9 -0.4 -5.67 -0.3 3.01e-8 Major depressive disorder; LUSC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg01503450 chr10:980765 NA -0.4 -5.81 -0.3 1.45e-8 Eosinophil percentage of granulocytes; LUSC cis rs17102423 0.685 rs7156617 chr14:65541381 G/A cg11161011 chr14:65562177 MAX -0.76 -11.16 -0.52 8.75e-25 Obesity-related traits; LUSC cis rs4343996 0.720 rs10250421 chr7:3458288 A/T cg21248987 chr7:3385318 SDK1 0.34 5.65 0.3 3.37e-8 Motion sickness; LUSC cis rs3018712 0.532 rs2510398 chr11:68421416 G/A cg22747802 chr11:68417633 NA -0.45 -6.26 -0.32 1.16e-9 Total body bone mineral density; LUSC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.51 -7.82 -0.39 7.19e-14 Personality dimensions; LUSC cis rs9937943 0.721 rs8059315 chr16:74506447 C/G cg01733217 chr16:74700730 RFWD3 0.65 7.67 0.39 1.86e-13 Neutrophil percentage of white cells; LUSC cis rs11645898 0.515 rs61747473 chr16:72258743 C/T cg14768367 chr16:72042858 DHODH -0.58 -5.92 -0.31 7.96e-9 Blood protein levels; LUSC cis rs7474896 0.616 rs2505239 chr10:38440765 A/G cg25427524 chr10:38739819 LOC399744 -0.52 -6.38 -0.33 5.9e-10 Obesity (extreme); LUSC cis rs9560113 0.960 rs1163862 chr13:112174319 C/T cg14154082 chr13:112174009 NA 0.37 8.07 0.4 1.27e-14 Menarche (age at onset); LUSC cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg11102782 chr19:18549136 ISYNA1 -0.35 -6.62 -0.34 1.44e-10 Breast cancer; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg22907277 chr7:1156413 C7orf50 0.48 7.26 0.37 2.77e-12 Longevity;Endometriosis; LUSC cis rs2236918 0.932 rs1635517 chr1:242012033 A/G cg17736920 chr1:242011382 EXO1 -0.47 -7.51 -0.38 5.58e-13 Menopause (age at onset); LUSC cis rs9311676 0.656 rs59643048 chr3:58390248 A/G cg13750441 chr3:58318267 PXK 0.35 6.75 0.35 6.64e-11 Systemic lupus erythematosus; LUSC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg06022373 chr22:39101656 GTPBP1 0.79 12.22 0.56 1.2e-28 Menopause (age at onset); LUSC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg23262073 chr20:60523788 NA -0.39 -6.09 -0.32 3.19e-9 Body mass index; LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs2777491 0.574 rs11635906 chr15:41779260 A/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -21.66 -0.76 1.33e-65 Ulcerative colitis; LUSC trans rs7681440 0.904 rs3806789 chr4:90759556 C/T cg02113368 chr10:135107346 TUBGCP2 -0.34 -5.95 -0.31 6.76e-9 Dementia with Lewy bodies; LUSC cis rs868036 0.609 rs2278076 chr15:68099600 C/T cg08079166 chr15:68083412 MAP2K5 0.49 8.49 0.42 6.75e-16 Restless legs syndrome; LUSC cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg03146154 chr1:46216737 IPP -0.55 -8.08 -0.4 1.22e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg05368731 chr17:41323189 NBR1 -0.83 -14.08 -0.61 1.14e-35 Menopause (age at onset); LUSC cis rs5769707 0.706 rs763128 chr22:50018045 G/A cg10356904 chr22:49881777 NA -0.28 -5.76 -0.3 1.87e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04193083 chr17:41323562 NBR1 -0.51 -6.08 -0.32 3.3e-9 Bipolar disorder and schizophrenia; LUSC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg16624210 chr5:671434 TPPP 0.5 6.31 0.33 8.97e-10 Obesity-related traits; LUSC cis rs7582720 0.943 rs72932575 chr2:203866857 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 8.37 0.42 1.63e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11644478 chr21:40555479 PSMG1 -0.75 -13.12 -0.58 5.27e-32 Cognitive function; LUSC cis rs955333 0.565 rs7770413 chr6:154904487 A/G cg20019720 chr6:154832845 CNKSR3 0.46 6.86 0.35 3.36e-11 Diabetic kidney disease; LUSC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg24399712 chr22:39784796 NA -0.62 -11.09 -0.52 1.53e-24 Intelligence (multi-trait analysis); LUSC cis rs6701037 1.000 rs7514749 chr1:175122123 A/G cg17845761 chr1:175162550 KIAA0040 -0.34 -6.51 -0.34 2.81e-10 Alcohol dependence; LUSC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.45 6.39 0.33 5.54e-10 Alzheimer's disease (late onset); LUSC cis rs7512552 0.839 rs1260367 chr1:150344514 C/T cg15654264 chr1:150340011 RPRD2 0.62 10.29 0.49 9.57e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg02782426 chr3:40428986 ENTPD3 0.4 7.66 0.39 1.97e-13 Renal cell carcinoma; LUSC cis rs16949788 1.000 rs7169463 chr15:66745929 G/C cg08120210 chr15:66682733 MAP2K1 -0.61 -6.17 -0.32 2.03e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6964587 0.967 rs7783414 chr7:91785957 C/T cg17063962 chr7:91808500 NA 0.59 9.55 0.46 2.8e-19 Breast cancer; LUSC cis rs12368653 0.789 rs17852479 chr12:58126234 C/A cg12615879 chr12:58013172 SLC26A10 0.39 9.25 0.45 2.81e-18 Multiple sclerosis; LUSC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg14664628 chr15:75095509 CSK -0.49 -7.01 -0.36 1.32e-11 Breast cancer; LUSC cis rs7312933 0.558 rs11181507 chr12:42844763 T/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.03 0.36 1.2e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs5769707 0.632 rs1476037 chr22:49991377 G/A cg20744362 chr22:50050164 C22orf34 0.36 6.74 0.35 6.84e-11 Monocyte count;Monocyte percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14341449 chr11:18034693 SERGEF -0.43 -6.39 -0.33 5.58e-10 Electrocardiographic conduction measures; LUSC cis rs7572733 0.576 rs6734781 chr2:198759973 G/A cg00792783 chr2:198669748 PLCL1 0.46 6.25 0.32 1.28e-9 Dermatomyositis; LUSC cis rs3859192 0.599 rs34342173 chr17:38161507 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.47 0.56 1.41e-29 White blood cell count; LUSC cis rs4499344 0.633 rs259260 chr19:33153261 G/A cg22980127 chr19:33182716 NUDT19 -0.44 -6.45 -0.33 3.88e-10 Mean platelet volume; LUSC cis rs9372253 0.678 rs6568644 chr6:110707820 C/T cg01119278 chr6:110721349 DDO -0.45 -8.09 -0.4 1.16e-14 Platelet distribution width; LUSC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg23711669 chr6:146136114 FBXO30 0.9 17.15 0.68 9.98e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs3857536 0.740 rs4710574 chr6:66890631 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC trans rs7819412 1.000 rs2409722 chr8:11039816 T/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.19 -0.32 1.72e-9 Triglycerides; LUSC trans rs617791 0.508 rs747526 chr11:65776071 C/A cg17712092 chr4:129076599 LARP1B -0.69 -9.81 -0.47 4.03e-20 Breast cancer; LUSC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg06873352 chr17:61820015 STRADA 0.57 8.78 0.43 8.9e-17 Height; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg00149659 chr3:10157352 C3orf10 0.9 12.53 0.57 8.81e-30 Alzheimer's disease; LUSC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg04155289 chr7:94953770 PON1 -0.35 -6.02 -0.31 4.7e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7539409 0.651 rs10747407 chr1:84314754 G/A cg10977910 chr1:84465055 TTLL7 0.74 7.85 0.39 5.82e-14 Alzheimer's disease; LUSC trans rs72674100 1.000 rs28656993 chr4:97965682 C/T cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs78707713 0.560 rs61848436 chr10:71247714 C/T cg12610070 chr10:71211762 TSPAN15 -0.48 -9.34 -0.46 1.42e-18 Venous thromboembolism; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.56 -8.87 -0.44 4.62e-17 Alzheimer's disease (late onset); LUSC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg00310523 chr12:86230176 RASSF9 -0.43 -8.06 -0.4 1.42e-14 Major depressive disorder; LUSC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg04455712 chr21:45112962 RRP1B 0.46 8.81 0.43 6.9e-17 Mean corpuscular volume; LUSC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg04155289 chr7:94953770 PON1 -0.34 -5.68 -0.3 2.96e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9329221 0.736 rs34381075 chr8:10243785 C/G cg27411982 chr8:10470053 RP1L1 0.44 6.39 0.33 5.72e-10 Neuroticism; LUSC cis rs548181 0.611 rs2849225 chr11:125415936 A/G cg03464685 chr11:125439445 EI24 1.36 14.72 0.63 3.83e-38 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9527 0.590 rs7920868 chr10:104795409 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.57 0.46 2.39e-19 Arsenic metabolism; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg11905131 chr22:24372483 LOC391322 -0.52 -8.89 -0.44 3.8e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg27129171 chr3:47204927 SETD2 0.56 8.01 0.4 1.88e-14 Birth weight; LUSC cis rs6918586 0.658 rs198837 chr6:26113398 A/T cg17691542 chr6:26056736 HIST1H1C -0.41 -6.06 -0.31 3.76e-9 Schizophrenia; LUSC cis rs7809950 0.723 rs2237662 chr7:106874065 C/G cg23024343 chr7:107201750 COG5 -0.66 -9.49 -0.46 4.46e-19 Coronary artery disease; LUSC cis rs7824557 0.545 rs2572380 chr8:11237477 A/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.79 -0.3 1.63e-8 Retinal vascular caliber; LUSC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9815354 1.000 rs56776628 chr3:41866856 A/G cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.6e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs11608355 0.545 rs12822891 chr12:109896002 A/G cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg04398451 chr17:18023971 MYO15A -0.48 -7.65 -0.39 2.12e-13 Total body bone mineral density; LUSC cis rs367943 0.666 rs10041899 chr5:112724742 A/T cg12552261 chr5:112820674 MCC 0.37 6.11 0.32 2.7e-9 Type 2 diabetes; LUSC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg02428538 chr16:24856791 SLC5A11 0.54 6.06 0.31 3.7e-9 Intelligence (multi-trait analysis); LUSC cis rs4566357 0.615 rs3769643 chr2:227917270 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -8.13 -0.41 8.48e-15 Coronary artery disease; LUSC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg11645453 chr3:52864694 ITIH4 0.31 7.32 0.37 1.84e-12 Bipolar disorder; LUSC cis rs7809950 1.000 rs10273733 chr7:107258121 A/G cg23024343 chr7:107201750 COG5 0.49 7.16 0.36 5.17e-12 Coronary artery disease; LUSC cis rs9341808 0.617 rs9294170 chr6:80814080 A/G cg08355045 chr6:80787529 NA 0.62 11.46 0.53 7.23e-26 Sitting height ratio; LUSC cis rs61990749 0.571 rs2364841 chr14:78284036 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.7 6.65 0.34 1.23e-10 Fibroblast growth factor basic levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14221825 chr19:46271408 SIX5 0.47 6.82 0.35 4.22e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs11039798 0.920 rs12279378 chr11:48571030 A/C cg15704280 chr7:45808275 SEPT13 0.69 6.51 0.34 2.81e-10 Axial length; LUSC trans rs6502050 0.805 rs11077970 chr17:80085916 C/T cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.34e-10 Life satisfaction; LUSC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.37 -6.41 -0.33 5.04e-10 High light scatter reticulocyte count; LUSC cis rs713477 0.505 rs4901561 chr14:55888578 T/C cg13175173 chr14:55914753 NA -0.31 -5.87 -0.31 1.07e-8 Pediatric bone mineral content (femoral neck); LUSC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg03289416 chr15:75166202 SCAMP2 0.45 7.06 0.36 9.73e-12 Breast cancer; LUSC cis rs2303282 0.716 rs6499834 chr16:56442734 C/T cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.88e-12 Breast cancer; LUSC trans rs12210905 1.000 rs3999221 chr6:26959322 C/G cg11837749 chr1:55047332 ACOT11 0.55 5.98 0.31 5.64e-9 Hip circumference adjusted for BMI; LUSC trans rs62169186 0.826 rs62169174 chr2:145046987 T/C cg02721902 chr17:46825371 NA -0.55 -5.99 -0.31 5.56e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6545883 0.929 rs778154 chr2:61646631 T/C cg15711740 chr2:61764176 XPO1 0.44 6.65 0.34 1.18e-10 Tuberculosis; LUSC cis rs7223966 1.000 rs2874121 chr17:61731024 C/T cg00945038 chr17:61921165 SMARCD2 0.38 5.69 0.3 2.74e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg11366901 chr6:160182831 ACAT2 0.93 12.69 0.57 2.24e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg10172584 chr19:19639581 YJEFN3 -0.46 -5.68 -0.3 3.01e-8 Bipolar disorder; LUSC cis rs10979 1.000 rs9386038 chr6:143896358 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.78 -0.39 8.84e-14 Myopia (pathological); LUSC cis rs7202877 0.656 rs8048677 chr16:75392028 C/G cg04384234 chr16:75411784 CFDP1 -0.64 -9.07 -0.44 1.08e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7819412 0.668 rs2409721 chr8:11038244 A/T cg21775007 chr8:11205619 TDH -0.5 -7.01 -0.36 1.36e-11 Triglycerides; LUSC cis rs259282 0.605 rs55687317 chr19:33109191 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.66 9.87 0.48 2.45e-20 Schizophrenia; LUSC cis rs1728785 0.901 rs7194664 chr16:68643313 T/C cg02972257 chr16:68554789 NA -0.51 -6.22 -0.32 1.51e-9 Ulcerative colitis; LUSC cis rs9611565 0.592 rs12484467 chr22:41957610 T/C cg06481639 chr22:41940642 POLR3H -0.52 -5.89 -0.31 9.37e-9 Vitiligo; LUSC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg04155289 chr7:94953770 PON1 -0.36 -6.12 -0.32 2.56e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg05585544 chr11:47624801 NA -0.42 -7.26 -0.37 2.71e-12 Subjective well-being; LUSC cis rs8072100 0.782 rs62074054 chr17:45771816 T/C cg19784903 chr17:45786737 TBKBP1 -0.42 -6.04 -0.31 4.05e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs11088226 0.750 rs2833885 chr21:33923161 A/G cg09050820 chr6:167586206 TCP10L2 0.64 9.17 0.45 4.94e-18 Gastritis; LUSC cis rs1847202 0.563 rs13095184 chr3:72951008 A/G cg25664220 chr3:72788482 NA -0.42 -7.62 -0.38 2.6e-13 Motion sickness; LUSC cis rs6121246 0.567 rs2889488 chr20:30185758 G/A cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.2e-10 Mean corpuscular hemoglobin; LUSC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg16339924 chr4:17578868 LAP3 0.57 8.79 0.43 8.02e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6964587 1.000 rs7811564 chr7:91663364 A/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.23e-8 Breast cancer; LUSC cis rs7829975 0.582 rs11783950 chr8:8597831 A/C cg08975724 chr8:8085496 FLJ10661 -0.47 -6.6 -0.34 1.57e-10 Mood instability; LUSC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg12463550 chr7:65579703 CRCP -0.49 -7.03 -0.36 1.19e-11 Aortic root size; LUSC trans rs6104690 1.000 rs6131143 chr20:10988150 A/G cg07172334 chr21:31655261 KRTAP24-1 -0.33 -5.94 -0.31 6.99e-9 Bladder cancer; LUSC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg09491104 chr22:46646882 C22orf40 -0.71 -7.14 -0.36 5.97e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs868036 0.609 rs16951304 chr15:68089618 T/C cg05925327 chr15:68127851 NA -0.48 -7.01 -0.36 1.35e-11 Restless legs syndrome; LUSC cis rs965469 1.000 rs2281494 chr20:3235494 A/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.84 -0.3 1.22e-8 IFN-related cytopenia; LUSC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg05738196 chr6:26577821 NA -0.61 -7.05 -0.36 1.06e-11 Intelligence (multi-trait analysis); LUSC cis rs6066835 1.000 rs4568007 chr20:47316575 C/G cg18078177 chr20:47281410 PREX1 0.72 6.13 0.32 2.51e-9 Multiple myeloma; LUSC cis rs12912251 1.000 rs35102843 chr15:38988107 C/A cg01338139 chr15:38987640 C15orf53 -0.5 -6.79 -0.35 5.12e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC trans rs6951245 1.000 rs11764748 chr7:1094508 T/C cg13565492 chr6:43139072 SRF -0.61 -6.49 -0.33 3.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14240646 chr10:27532245 ACBD5 -0.83 -14.33 -0.62 1.25e-36 Breast cancer; LUSC trans rs7615952 0.599 rs2270986 chr3:125701099 T/C cg07211511 chr3:129823064 LOC729375 -0.81 -10.63 -0.5 6.5e-23 Blood pressure (smoking interaction); LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg02018176 chr4:1364513 KIAA1530 -0.66 -11.82 -0.54 3.52e-27 Obesity-related traits; LUSC cis rs2562456 0.917 rs2562471 chr19:21715819 C/T cg00806126 chr19:22604979 ZNF98 0.37 5.71 0.3 2.43e-8 Pain; LUSC cis rs6835098 0.962 rs4419455 chr4:174083622 C/T cg27433088 chr4:174089019 GALNT7 -0.41 -5.83 -0.3 1.33e-8 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg12419862 chr22:24373484 LOC391322 -0.87 -14.22 -0.61 3.27e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3020736 0.500 rs6002623 chr22:42513761 G/A cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg13395646 chr4:1353034 KIAA1530 0.54 7.65 0.39 2.21e-13 Longevity; LUSC cis rs2070488 0.775 rs4407366 chr3:38521425 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.69 11.96 0.55 1.12e-27 Electrocardiographic conduction measures; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg13560548 chr3:10150139 C3orf24 0.51 7.35 0.37 1.56e-12 Alzheimer's disease; LUSC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg25072359 chr17:41440525 NA 0.66 9.52 0.46 3.7e-19 Menopause (age at onset); LUSC cis rs17102884 0.506 rs11845397 chr14:75404587 G/A cg06637938 chr14:75390232 RPS6KL1 -0.43 -6.42 -0.33 4.67e-10 Neuroticism; LUSC cis rs73206853 0.841 rs56117211 chr12:111123485 T/G cg12870014 chr12:110450643 ANKRD13A 0.67 6.42 0.33 4.58e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6543140 0.964 rs2141781 chr2:103082906 G/A cg09003973 chr2:102972529 NA 0.53 6.75 0.35 6.5500000000000006e-11 Blood protein levels; LUSC cis rs8072100 0.745 rs7214410 chr17:45422628 A/G cg08085267 chr17:45401833 C17orf57 -0.56 -8.88 -0.44 4.29e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7095944 0.584 rs10901814 chr10:126431281 G/C cg08799069 chr10:126477246 METTL10 -0.39 -5.96 -0.31 6.28e-9 Asthma; LUSC cis rs2486288 0.656 rs12904150 chr15:45547605 T/C cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.76 -0.51 2.15e-23 Glomerular filtration rate; LUSC cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg05072774 chr3:49840536 C3orf54 -0.42 -5.68 -0.3 2.94e-8 Resting heart rate; LUSC cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.58 -8.47 -0.42 7.76e-16 Colorectal cancer; LUSC cis rs9640161 0.830 rs11768108 chr7:150064150 C/T cg27494647 chr7:150038898 RARRES2 0.44 6.57 0.34 1.95e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs6543140 0.964 rs13383602 chr2:103085962 C/T cg09003973 chr2:102972529 NA 0.53 6.75 0.35 6.5500000000000006e-11 Blood protein levels; LUSC cis rs6599077 1.000 rs6808524 chr3:40097129 A/G cg13683864 chr3:40499215 RPL14 -0.59 -7.56 -0.38 3.95e-13 Sleep-related phenotypes; LUSC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.59 7.88 0.4 4.72e-14 Alzheimer's disease; LUSC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg07701084 chr6:150067640 NUP43 0.57 8.73 0.43 1.28e-16 Lung cancer; LUSC cis rs7586879 0.789 rs13398155 chr2:25128550 C/T cg01884057 chr2:25150051 NA 0.42 8.82 0.43 6.24e-17 Body mass index; LUSC cis rs1153858 1.000 rs2461701 chr15:45703391 G/A cg14582100 chr15:45693742 SPATA5L1 0.56 10.09 0.48 4.35e-21 Homoarginine levels; LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg13047869 chr3:10149882 C3orf24 0.56 7.72 0.39 1.37e-13 Alzheimer's disease; LUSC trans rs877282 1.000 rs877281 chr10:771557 T/G cg13042288 chr15:90349979 ANPEP -0.48 -6.75 -0.35 6.37e-11 Uric acid levels; LUSC cis rs6847149 1.000 rs7669266 chr4:110804131 C/T cg07850274 chr4:110748770 RRH 0.59 7.96 0.4 2.74e-14 Exercise treadmill test traits; LUSC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg18681998 chr4:17616180 MED28 0.85 15.66 0.65 7.79e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.4 -0.38 1.15e-12 Psoriasis; LUSC trans rs61931739 0.500 rs11053217 chr12:34470036 A/C cg13010199 chr12:38710504 ALG10B 0.59 9.46 0.46 5.59e-19 Morning vs. evening chronotype; LUSC cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg02527881 chr3:46936655 PTH1R 0.38 6.38 0.33 5.8e-10 Colorectal cancer; LUSC trans rs6445525 1.000 rs4688259 chr3:65995266 T/C cg12639933 chr12:57626296 SHMT2 0.34 6.18 0.32 1.82e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12594515 1.000 rs6493169 chr15:45986994 A/G cg01629716 chr15:45996671 NA -0.4 -6.18 -0.32 1.91e-9 Waist circumference;Weight; LUSC trans rs1005277 0.579 rs1740732 chr10:38491385 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.35 -0.46 1.25e-18 Extrinsic epigenetic age acceleration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15643885 chr8:17434749 PDGFRL 0.53 8.06 0.4 1.4e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12541635 0.677 rs55639043 chr8:107055993 C/T cg10147462 chr8:107024639 NA 0.66 13.82 0.6 1.17e-34 Age of smoking initiation; LUSC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.51 0.34 2.68e-10 Lung cancer; LUSC cis rs6542838 0.611 rs1976766 chr2:99522754 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.01 -0.31 4.78e-9 Fear of minor pain; LUSC cis rs6489882 0.703 rs10774673 chr12:113361158 C/T cg20102336 chr12:113376681 OAS3 -0.4 -5.71 -0.3 2.46e-8 Chronic lymphocytic leukemia; LUSC cis rs2742234 0.541 rs10793427 chr10:43747443 G/A cg15436174 chr10:43711423 RASGEF1A 0.43 6.85 0.35 3.63e-11 Hirschsprung disease; LUSC cis rs672059 0.934 rs641057 chr1:183156859 A/G ch.1.3577855R chr1:183094577 LAMC1 0.54 7.99 0.4 2.15e-14 Hypertriglyceridemia; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg23985595 chr17:80112537 CCDC57 0.31 6.0 0.31 5.22e-9 Life satisfaction; LUSC cis rs13315871 0.929 rs73835170 chr3:58318448 A/G cg12435725 chr3:58293450 RPP14 -0.71 -7.18 -0.37 4.5e-12 Cholesterol, total; LUSC cis rs11098499 0.739 rs10031033 chr4:120151452 C/T cg09307838 chr4:120376055 NA 0.54 8.33 0.41 2.09e-15 Corneal astigmatism; LUSC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg23188684 chr11:67383651 NA 0.42 7.79 0.39 8.52e-14 Mean corpuscular volume; LUSC cis rs11155671 0.530 rs7768626 chr6:150207962 G/T cg13206674 chr6:150067644 NUP43 0.43 6.56 0.34 2.01e-10 Testicular germ cell tumor; LUSC cis rs9300255 0.507 rs1727302 chr12:123632930 G/A cg13010344 chr12:123464640 ARL6IP4 -0.47 -6.99 -0.36 1.5e-11 Neutrophil percentage of white cells; LUSC cis rs67311347 0.577 rs2371129 chr3:40248393 C/T cg13683864 chr3:40499215 RPL14 0.84 13.81 0.6 1.21e-34 Renal cell carcinoma; LUSC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.05 -0.31 3.92e-9 Huntington's disease progression; LUSC cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg21535247 chr6:8435926 SLC35B3 0.56 8.56 0.42 4.06e-16 Motion sickness; LUSC cis rs4285028 0.747 rs7623901 chr3:121529011 A/G cg11130432 chr3:121712080 ILDR1 0.64 9.58 0.46 2.33e-19 Multiple sclerosis; LUSC cis rs9300255 0.739 rs4759371 chr12:123742563 T/C cg00376283 chr12:123451042 ABCB9 0.66 8.32 0.41 2.27e-15 Neutrophil percentage of white cells; LUSC cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7212590 0.618 rs7217337 chr17:58023417 C/T cg10252138 chr17:58120427 NA -0.82 -7.64 -0.39 2.33e-13 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs8072100 0.713 rs57427906 chr17:45494014 G/A cg08085267 chr17:45401833 C17orf57 -0.5 -7.24 -0.37 3.11e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6665290 0.904 rs10495273 chr1:227183359 T/G cg10327440 chr1:227177885 CDC42BPA -1.21 -40.08 -0.91 1.14e-129 Myeloid white cell count; LUSC cis rs4478037 1.000 rs4076086 chr3:33161898 C/T cg19404215 chr3:33155277 CRTAP 0.96 10.11 0.48 4.01e-21 Major depressive disorder; LUSC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg07741184 chr6:167504864 NA -0.35 -6.42 -0.33 4.78e-10 Crohn's disease; LUSC cis rs826838 1.000 rs826886 chr12:39095797 A/G cg13010199 chr12:38710504 ALG10B 0.61 10.34 0.49 6.57e-22 Heart rate; LUSC cis rs3806843 1.000 rs6870764 chr5:140171790 C/T cg19875535 chr5:140030758 IK 0.5 8.28 0.41 3.06e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg21028142 chr17:79581711 NPLOC4 0.34 8.17 0.41 6.66e-15 Eye color traits; LUSC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg25282410 chr6:160211355 TCP1;MRPL18 1.12 17.29 0.69 2.67e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs654351 0.543 rs622388 chr6:10387117 T/G cg17959970 chr6:10383164 NA -0.36 -6.72 -0.35 7.67e-11 Squamous cell lung carcinoma; LUSC trans rs6076960 0.684 rs3852949 chr20:6264758 T/A cg17788362 chr6:86352627 SYNCRIP 0.49 7.39 0.37 1.17e-12 Smooth-surface caries; LUSC cis rs9527 0.567 rs6584539 chr10:104879402 G/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs899997 0.862 rs4887074 chr15:78952110 G/C cg04896959 chr15:78267971 NA 0.44 8.64 0.43 2.44e-16 Coronary artery disease or large artery stroke; LUSC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg02428538 chr16:24856791 SLC5A11 -0.52 -6.05 -0.31 3.82e-9 Intelligence (multi-trait analysis); LUSC cis rs796825 0.530 rs13091848 chr3:119986024 T/G cg21790991 chr3:120137480 FSTL1 -0.34 -6.1 -0.32 2.93e-9 HIV-1 susceptibility; LUSC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18404041 chr3:52824283 ITIH1 -0.51 -9.86 -0.47 2.66e-20 Bipolar disorder; LUSC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg01579765 chr21:45077557 HSF2BP -0.54 -11.58 -0.54 2.64e-26 Mean corpuscular volume; LUSC cis rs11190604 1.000 rs11190595 chr10:102291761 T/C cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs45535039 1.000 rs7104210 chr11:119073886 T/G cg16724696 chr11:118992527 HINFP 0.45 5.68 0.3 2.94e-8 Plateletcrit; LUSC cis rs6987853 0.787 rs2923436 chr8:42425298 G/A cg09913449 chr8:42400586 C8orf40 0.5 8.45 0.42 9.37e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg00810483 chr4:3375144 RGS12 0.32 6.02 0.31 4.62e-9 Serum sulfate level; LUSC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg24562669 chr7:97807699 LMTK2 0.34 5.91 0.31 8.4e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg03168497 chr17:48586147 MYCBPAP -0.58 -8.67 -0.43 1.87e-16 Visceral fat; LUSC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.47 0.33 3.59e-10 Lung cancer; LUSC cis rs11098499 0.863 rs58452170 chr4:120459674 A/T cg24375607 chr4:120327624 NA 0.77 11.31 0.53 2.57e-25 Corneal astigmatism; LUSC trans rs9329221 0.686 rs13264580 chr8:10250699 C/T cg15556689 chr8:8085844 FLJ10661 0.65 9.08 0.44 9.67e-18 Neuroticism; LUSC cis rs12313068 0.709 rs11064912 chr12:110505699 A/T cg12870014 chr12:110450643 ANKRD13A -0.66 -9.96 -0.48 1.28e-20 Intelligence (multi-trait analysis); LUSC cis rs11167764 1.000 rs6580220 chr5:141480558 G/A cg23435118 chr5:141488016 NDFIP1 -0.56 -7.95 -0.4 2.93e-14 Crohn's disease; LUSC cis rs713587 0.521 rs6545766 chr2:25077856 C/T cg04586622 chr2:25135609 ADCY3 0.37 7.53 0.38 4.93e-13 Body mass index in non-asthmatics; LUSC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg05347473 chr6:146136440 FBXO30 0.41 7.05 0.36 1.06e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg00603274 chr11:61596626 FADS2 -0.57 -7.66 -0.39 2.02e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs13253111 0.624 rs13277389 chr8:28100234 G/T cg26534493 chr8:28060551 NA 0.38 6.92 0.35 2.28e-11 Childhood body mass index; LUSC trans rs6945197 1.000 rs2349748 chr7:136130536 C/T cg25184248 chr3:123813393 KALRN 0.77 5.97 0.31 5.92e-9 Late-onset Alzheimer's disease; LUSC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.67 0.39 1.85e-13 Eosinophil percentage of white cells; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg09906747 chr21:34914446 SON;GART 0.45 6.21 0.32 1.56e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4363385 0.818 rs382653 chr1:153006761 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs9549367 0.713 rs3024776 chr13:113827075 A/G cg00898013 chr13:113819073 PROZ 0.62 8.84 0.44 5.64e-17 Platelet distribution width; LUSC cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.06 0.4 1.35e-14 Axial length; LUSC cis rs1775715 0.737 rs12256714 chr10:32216262 A/G cg26784012 chr10:32216390 ARHGAP12 -0.41 -6.92 -0.35 2.28e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6740322 0.901 rs2163228 chr2:43549246 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.44 -5.8 -0.3 1.53e-8 Coronary artery disease; LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs12579753 0.917 rs7954438 chr12:82184419 T/C cg07923666 chr12:49932857 KCNH3 -0.49 -6.1 -0.32 3e-9 Resting heart rate; LUSC trans rs2204008 0.774 rs11520237 chr12:38266978 G/A cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.74e-9 Bladder cancer; LUSC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg18230493 chr5:56204884 C5orf35 -0.87 -13.0 -0.58 1.52e-31 Initial pursuit acceleration; LUSC cis rs2250402 0.510 rs8031319 chr15:40323692 A/G cg10636054 chr15:40330586 SRP14 0.88 8.33 0.41 2.17e-15 Corneal curvature; LUSC cis rs6964587 0.967 rs34574955 chr7:91847550 A/C cg22709100 chr7:91322751 NA 0.39 5.71 0.3 2.56e-8 Breast cancer; LUSC trans rs208520 0.955 rs9345808 chr6:67008262 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.74 9.24 0.45 2.9e-18 Exhaled nitric oxide output; LUSC cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg23583168 chr7:148888333 NA -0.88 -16.83 -0.68 1.92e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6005807 0.719 rs73430118 chr22:28913950 C/T cg12565055 chr22:29076175 TTC28 0.55 5.74 0.3 2.14e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2769264 0.546 rs12047617 chr1:151392597 G/A cg18801370 chr1:151430492 POGZ 0.68 8.29 0.41 2.88e-15 Blood trace element (Cu levels); LUSC trans rs9329221 0.662 rs13254942 chr8:10257678 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.81 -0.35 4.56e-11 Neuroticism; LUSC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs8099014 0.906 rs4940688 chr18:56089044 G/A cg12907477 chr18:56117327 MIR122 0.43 6.72 0.35 7.66e-11 Platelet count; LUSC cis rs4494114 0.967 rs9438978 chr1:39355058 G/T cg25970120 chr1:39325951 RRAGC -0.4 -6.33 -0.33 7.99e-10 Blood protein levels; LUSC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg07741184 chr6:167504864 NA 0.44 7.76 0.39 1.03e-13 Crohn's disease; LUSC trans rs9393777 0.844 rs28360634 chr6:27332891 T/C cg01620082 chr3:125678407 NA -0.78 -6.94 -0.36 1.98e-11 Intelligence (multi-trait analysis); LUSC cis rs2795502 0.564 rs72777186 chr10:43430464 C/T cg08461752 chr10:43522343 NA -0.55 -6.67 -0.34 1.06e-10 Blood protein levels; LUSC cis rs34779708 0.966 rs34605125 chr10:35411246 A/G cg03585969 chr10:35415529 CREM 0.6 8.8 0.43 7.66e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6960043 0.875 rs6976381 chr7:15048814 T/C cg19272540 chr7:15055459 NA -0.3 -7.23 -0.37 3.26e-12 Type 2 diabetes; LUSC cis rs12681287 0.547 rs66808088 chr8:87521212 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.27 -0.37 2.53e-12 Caudate activity during reward; LUSC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 18.1 0.7 1.66e-51 Chronic sinus infection; LUSC cis rs79349575 0.783 rs4793995 chr17:47019399 A/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs11098499 0.866 rs6857892 chr4:120282696 G/T cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs559928 0.597 rs947939 chr11:63885287 C/T cg05555928 chr11:63887634 MACROD1 -0.48 -6.19 -0.32 1.74e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs12999616 0.817 rs55933640 chr2:98328721 C/T cg26665480 chr2:98280029 ACTR1B 0.52 5.94 0.31 7.15e-9 Colorectal cancer; LUSC trans rs1005277 0.505 rs200939 chr10:38139483 T/C cg17830980 chr10:43048298 ZNF37B -0.43 -6.64 -0.34 1.28e-10 Extrinsic epigenetic age acceleration; LUSC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg13628971 chr7:2884303 GNA12 0.49 6.82 0.35 4.33e-11 Height; LUSC cis rs2439831 1.000 rs690002 chr15:43729349 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.97 10.95 0.51 4.92e-24 Lung cancer in ever smokers; LUSC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg11663144 chr21:46675770 NA -0.43 -7.67 -0.39 1.92e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg06808227 chr14:105710500 BRF1 -0.7 -11.24 -0.52 4.32e-25 Mean platelet volume;Platelet distribution width; LUSC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg18876405 chr7:65276391 NA 0.68 12.13 0.55 2.6e-28 Aortic root size; LUSC cis rs7829975 0.582 rs6982832 chr8:8792217 A/C cg06636001 chr8:8085503 FLJ10661 -0.53 -8.37 -0.42 1.64e-15 Mood instability; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -8.12 -0.41 9.16e-15 Lymphocyte counts; LUSC cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 -0.34 -5.71 -0.3 2.52e-8 Bone mineral density (spine);Bone mineral density; LUSC trans rs76248362 1.000 rs7998585 chr13:24435195 C/T cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs1728785 1.000 rs864742 chr16:68575309 T/C cg02508848 chr16:68573721 ZFP90 -0.42 -5.75 -0.3 2.07e-8 Ulcerative colitis; LUSC trans rs9929218 0.551 rs8051095 chr16:68722049 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.1 26.61 0.82 1.59e-84 Colorectal cancer; LUSC cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.95 0.36 1.9e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12220238 1.000 rs10824076 chr10:75886956 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.63 7.7 0.39 1.54e-13 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9894429 0.624 rs9910935 chr17:79613949 T/C cg18240062 chr17:79603768 NPLOC4 0.8 15.58 0.65 1.64e-41 Eye color traits; LUSC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg06221963 chr1:154839813 KCNN3 0.64 14.23 0.61 3.03e-36 Prostate cancer; LUSC trans rs11098499 0.954 rs2306455 chr4:120421969 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg25428297 chr7:1022841 CYP2W1 0.3 6.48 0.33 3.26e-10 Longevity;Endometriosis; LUSC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg05295671 chr13:79234353 RNF219 0.46 6.41 0.33 5.06e-10 Large artery stroke; LUSC cis rs1595825 0.945 rs59553483 chr2:198855201 T/C cg00982548 chr2:198649783 BOLL -0.54 -6.83 -0.35 4.14e-11 Ulcerative colitis; LUSC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg05776053 chr2:74358815 NA 0.45 6.44 0.33 4.18e-10 Gestational age at birth (maternal effect); LUSC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg25456477 chr12:86230367 RASSF9 0.33 5.78 0.3 1.68e-8 Major depressive disorder; LUSC cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg02423579 chr7:2872169 GNA12 -0.42 -6.39 -0.33 5.53e-10 Height; LUSC cis rs7577696 0.554 rs3769605 chr2:32322456 A/G cg02381751 chr2:32503542 YIPF4 -0.52 -7.05 -0.36 1.01e-11 Inflammatory biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26346718 chr17:79482045 NA -0.5 -6.09 -0.32 3.17e-9 Bipolar disorder and schizophrenia; LUSC cis rs3862030 0.694 rs12781742 chr10:104227469 G/A cg22532475 chr10:104410764 TRIM8 0.25 5.87 0.31 1.03e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2249625 0.584 rs2496506 chr6:72891324 A/C cg18830697 chr6:72922368 RIMS1 -0.37 -7.43 -0.38 9.01e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs921968 0.541 rs523937 chr2:219437596 G/C cg02176678 chr2:219576539 TTLL4 0.75 14.64 0.63 7.48e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.9 -11.75 -0.54 6.7399999999999993e-27 Chronic sinus infection; LUSC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.52 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg14668632 chr7:2872130 GNA12 -0.44 -6.26 -0.32 1.21e-9 Height; LUSC cis rs9395066 0.545 rs35813980 chr6:44956008 C/T cg25276700 chr6:44698697 NA 0.29 5.8 0.3 1.53e-8 Height; LUSC cis rs9902453 0.817 rs1842026 chr17:28188111 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.67 0.47 1.16e-19 Coffee consumption (cups per day); LUSC cis rs4474465 0.736 rs10899542 chr11:78246572 T/G cg27205649 chr11:78285834 NARS2 0.5 6.1 0.32 2.94e-9 Alzheimer's disease (survival time); LUSC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg19046167 chr17:80928561 B3GNTL1 -0.45 -6.56 -0.34 2.07e-10 Breast cancer; LUSC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.45 -8.18 -0.41 5.9e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs13089785 0.965 rs12493045 chr3:123620718 C/A cg02558132 chr3:123411198 MYLK 0.36 6.21 0.32 1.59e-9 Intelligence (multi-trait analysis); LUSC cis rs2692947 0.864 rs2579518 chr2:96675259 G/A cg22654517 chr2:96458247 NA 0.35 7.0 0.36 1.38e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg02772935 chr3:125709198 NA -0.49 -5.89 -0.31 9.62e-9 Blood pressure (smoking interaction); LUSC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg13393036 chr8:95962371 TP53INP1 -0.46 -9.57 -0.46 2.53e-19 Type 2 diabetes; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg13397359 chr6:42928475 GNMT -0.65 -11.15 -0.52 9.07e-25 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg23649088 chr2:200775458 C2orf69 0.49 6.77 0.35 5.85e-11 Schizophrenia; LUSC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg07936489 chr17:37558343 FBXL20 -0.72 -9.91 -0.48 1.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs561341 0.714 rs7218466 chr17:30263314 A/G cg00745463 chr17:30367425 LRRC37B -0.67 -7.89 -0.4 4.47e-14 Hip circumference adjusted for BMI; LUSC cis rs9467773 0.620 rs2130657 chr6:26650826 C/T cg11502198 chr6:26597334 ABT1 0.73 12.25 0.56 9.63e-29 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg05585544 chr11:47624801 NA 0.41 7.25 0.37 2.92e-12 Subjective well-being; LUSC cis rs7582180 0.629 rs4851298 chr2:100949827 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg19717773 chr7:2847554 GNA12 -0.39 -6.33 -0.33 7.72e-10 Height; LUSC cis rs62027291 0.605 rs62030413 chr15:76878201 A/G cg26408565 chr15:76604113 ETFA 0.75 6.95 0.36 1.98e-11 Plateletcrit; LUSC cis rs7089973 0.872 rs34064819 chr10:116621154 C/A cg23260525 chr10:116636907 FAM160B1 0.4 8.1 0.41 1.02e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs5769765 0.862 rs7410537 chr22:50317330 G/A cg26441486 chr22:50317300 CRELD2 0.49 7.18 0.37 4.63e-12 Schizophrenia; LUSC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg18827107 chr12:86230957 RASSF9 -0.43 -6.37 -0.33 6.35e-10 Major depressive disorder; LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg01879757 chr17:41196368 BRCA1 -0.47 -7.2 -0.37 3.93e-12 Menopause (age at onset); LUSC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg03433033 chr1:76189801 ACADM 0.79 12.54 0.57 8.31e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8028313 0.630 rs8035989 chr15:67965620 G/A cg08079166 chr15:68083412 MAP2K5 0.36 6.23 0.32 1.39e-9 Obesity; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg26335602 chr6:28129616 ZNF389 0.5 6.66 0.34 1.12e-10 Parkinson's disease; LUSC cis rs6500602 0.702 rs56895104 chr16:4548132 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 6.84 0.35 3.79e-11 Schizophrenia; LUSC cis rs9814567 1.000 rs9826496 chr3:134224437 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.97 -0.61 3.08e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7824557 0.628 rs3779891 chr8:11183505 G/A cg21293242 chr8:11204541 TDH 0.34 6.38 0.33 6.04e-10 Retinal vascular caliber; LUSC cis rs760805 0.965 rs4648883 chr1:25261203 T/C cg22509179 chr1:25234806 RUNX3 -0.59 -9.97 -0.48 1.19e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg17264618 chr3:40429014 ENTPD3 0.33 7.02 0.36 1.28e-11 Renal cell carcinoma; LUSC trans rs61931739 0.500 rs1601628 chr12:34047375 A/C cg26384229 chr12:38710491 ALG10B 0.7 10.84 0.51 1.21e-23 Morning vs. evening chronotype; LUSC cis rs9807841 0.670 rs2010492 chr19:10803395 A/G cg17710535 chr19:10819994 QTRT1 0.42 6.79 0.35 5.11e-11 Inflammatory skin disease; LUSC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg08888203 chr3:10149979 C3orf24 0.48 7.21 0.37 3.81e-12 Alzheimer's disease; LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg05368731 chr17:41323189 NBR1 0.93 16.01 0.66 3.23e-43 Menopause (age at onset); LUSC cis rs1448094 0.717 rs7298614 chr12:86296513 C/T cg25456477 chr12:86230367 RASSF9 0.38 6.66 0.34 1.11e-10 Major depressive disorder; LUSC cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs12594515 1.000 rs6493176 chr15:45990026 A/G cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs6942756 0.688 rs2718089 chr7:128927022 G/T cg02491457 chr7:128862824 NA 0.49 7.3 0.37 2.13e-12 White matter hyperintensity burden; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg07677032 chr17:61819896 STRADA 0.49 8.34 0.42 1.94e-15 Prudent dietary pattern; LUSC cis rs61931739 0.500 rs11524949 chr12:34435551 C/T cg06521331 chr12:34319734 NA -0.39 -6.03 -0.31 4.33e-9 Morning vs. evening chronotype; LUSC cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.64 0.47 1.45e-19 Arsenic metabolism; LUSC cis rs3806843 0.966 rs10053945 chr5:140160127 C/T cg26395211 chr5:140044315 WDR55 -0.39 -6.0 -0.31 5.16e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg01579765 chr21:45077557 HSF2BP -0.54 -11.34 -0.53 1.89e-25 Mean corpuscular volume; LUSC cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg11266682 chr4:10021025 SLC2A9 0.57 10.18 0.49 2.18e-21 Bone mineral density; LUSC cis rs11711311 0.955 rs9813630 chr3:113377361 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -6.2 -0.32 1.64e-9 IgG glycosylation; LUSC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs9318086 0.648 rs9510927 chr13:24467641 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.45 6.62 0.34 1.4e-10 Myopia (pathological); LUSC cis rs9560113 0.573 rs9560134 chr13:112244011 C/T cg10483660 chr13:112241077 NA 0.34 5.73 0.3 2.19e-8 Menarche (age at onset); LUSC cis rs4664308 1.000 rs925410 chr2:160912652 C/T cg03641300 chr2:160917029 PLA2R1 0.66 11.29 0.53 3.02e-25 Idiopathic membranous nephropathy; LUSC cis rs11608355 0.573 rs7970666 chr12:109793495 T/G cg19025524 chr12:109796872 NA -0.49 -9.24 -0.45 2.91e-18 Neuroticism; LUSC cis rs7250872 0.647 rs12976128 chr19:1817113 A/C cg10370574 chr19:1840461 REXO1 -0.56 -7.95 -0.4 2.98e-14 Bipolar disorder; LUSC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08704250 chr15:31115839 NA -0.47 -7.03 -0.36 1.14e-11 Huntington's disease progression; LUSC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.57 -0.34 1.92e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6087990 0.735 rs4911261 chr20:31391360 A/G cg13636640 chr20:31349939 DNMT3B 0.93 18.92 0.72 9.01e-55 Ulcerative colitis; LUSC cis rs7178572 0.633 rs11857860 chr15:77839761 T/C cg22256960 chr15:77711686 NA -0.47 -7.03 -0.36 1.19e-11 Type 2 diabetes; LUSC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.67 0.5 4.47e-23 Monocyte percentage of white cells; LUSC cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.82e-13 Motion sickness; LUSC cis rs3809863 0.602 rs2317677 chr17:45393407 G/A cg08085267 chr17:45401833 C17orf57 -0.64 -9.63 -0.47 1.5700000000000001e-19 Glaucoma (primary open-angle); LUSC cis rs11711311 0.955 rs3796254 chr3:113380332 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.67 0.34 1.06e-10 IgG glycosylation; LUSC cis rs13315871 1.000 rs13076951 chr3:58436703 C/T cg20936604 chr3:58311152 NA -0.72 -6.77 -0.35 5.83e-11 Cholesterol, total; LUSC trans rs11098499 0.863 rs1552092 chr4:120488496 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.61 0.34 1.48e-10 Corneal astigmatism; LUSC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.47 8.11 0.41 9.61e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618501 0.735 rs9876508 chr3:49780844 G/A cg24110177 chr3:50126178 RBM5 0.43 6.83 0.35 4.05e-11 Intelligence (multi-trait analysis); LUSC cis rs9583531 0.689 rs2165418 chr13:111379365 G/T cg24331049 chr13:111365604 ING1 -0.57 -7.73 -0.39 1.26e-13 Coronary artery disease; LUSC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg03806693 chr22:41940476 POLR3H 0.99 13.72 0.6 2.7200000000000002e-34 Crohn's disease;Inflammatory bowel disease; LUSC trans rs7829975 0.509 rs7838674 chr8:8797073 A/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.38 -0.33 5.91e-10 Mood instability; LUSC cis rs72627509 1.000 rs72627509 chr4:57839051 C/G cg26694713 chr4:57773883 REST 0.51 5.98 0.31 5.76e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg18350739 chr11:68623251 NA -0.38 -6.91 -0.35 2.52e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs694739 0.892 rs647152 chr11:64109118 T/G cg26898376 chr11:64110657 CCDC88B 0.37 7.09 0.36 7.97e-12 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg15445000 chr17:37608096 MED1 0.41 6.84 0.35 3.85e-11 Glomerular filtration rate (creatinine); LUSC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC trans rs12188164 0.610 rs6555242 chr5:416546 A/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 6.12 0.32 2.65e-9 Cystic fibrosis severity; LUSC cis rs4682868 0.581 rs6774801 chr3:42923776 A/C cg21365077 chr3:42922735 NA -0.41 -5.85 -0.3 1.18e-8 Monocyte percentage of white cells; LUSC cis rs4900538 0.819 rs72698595 chr14:102863099 G/A cg18135206 chr14:102964638 TECPR2 -1.01 -19.97 -0.74 6.28e-59 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2361718 0.527 rs11150847 chr17:78153130 G/A cg09238746 chr17:78121135 EIF4A3 -0.47 -6.7 -0.34 8.79e-11 Yeast infection; LUSC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg16339924 chr4:17578868 LAP3 0.59 9.2 0.45 3.85e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg24375607 chr4:120327624 NA 0.79 12.05 0.55 5.41e-28 Corneal astigmatism; LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.36 -0.46 1.24e-18 Gut microbiome composition (summer); LUSC cis rs662064 0.962 rs2506902 chr1:10563681 C/T cg20482658 chr1:10539492 PEX14 0.33 6.64 0.34 1.25e-10 Asthma; LUSC cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg08213375 chr14:104286397 PPP1R13B 0.52 9.99 0.48 1e-20 Schizophrenia; LUSC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.71 0.39 1.41e-13 Parkinson's disease; LUSC cis rs7215564 0.908 rs35071767 chr17:78652575 A/G cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg03676636 chr4:99064102 C4orf37 0.36 7.84 0.39 6.23e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.913 rs67947146 chr11:68314980 C/T cg20283391 chr11:68216788 NA -0.61 -8.46 -0.42 8.4e-16 Total body bone mineral density; LUSC trans rs3749237 0.929 rs62260715 chr3:49829326 G/A cg21659725 chr3:3221576 CRBN 0.62 8.53 0.42 5.06e-16 Resting heart rate; LUSC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg08280861 chr8:58055591 NA 0.48 6.05 0.31 3.82e-9 Developmental language disorder (linguistic errors); LUSC cis rs2857891 0.650 rs2857928 chr11:6989721 C/G cg14883916 chr11:6947541 ZNF215 -0.42 -5.65 -0.3 3.45e-8 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs561341 0.783 rs512698 chr17:30292507 G/T cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg23711669 chr6:146136114 FBXO30 0.72 12.82 0.57 7.47e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs2932538 0.885 rs3762335 chr1:113100548 C/T cg22162597 chr1:113214053 CAPZA1 0.69 9.93 0.48 1.6e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg24250549 chr1:154909240 PMVK 0.44 6.76 0.35 6.35e-11 Prostate cancer; LUSC trans rs60843830 0.661 rs6755432 chr2:106692 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.51 8.0 0.4 2.12e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg07157834 chr1:205819609 PM20D1 0.47 6.72 0.35 7.93e-11 Prostate-specific antigen levels; LUSC trans rs853679 0.517 rs3173443 chr6:28137027 T/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.21 -0.37 3.86e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg21880101 chr17:80066754 CCDC57 -0.31 -5.8 -0.3 1.54e-8 Life satisfaction; LUSC cis rs425277 1.000 rs262651 chr1:2091397 A/G cg03732007 chr1:2071316 PRKCZ 0.47 7.53 0.38 4.67e-13 Height; LUSC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg18351406 chr4:77819688 ANKRD56 0.57 8.3 0.41 2.58e-15 Emphysema distribution in smoking; LUSC cis rs741677 0.702 rs9893847 chr17:489043 C/G cg06217071 chr17:408420 NA -0.34 -6.03 -0.31 4.37e-9 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); LUSC cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.21 29.65 0.85 1.46e-95 Chronic sinus infection; LUSC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -6.5 -0.33 2.99e-10 Developmental language disorder (linguistic errors); LUSC cis rs6456156 0.586 rs12213801 chr6:167474084 T/A cg25258033 chr6:167368657 RNASET2 0.37 5.76 0.3 1.91e-8 Primary biliary cholangitis; LUSC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg22800045 chr5:56110881 MAP3K1 0.71 9.47 0.46 5.45e-19 Initial pursuit acceleration; LUSC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg20243544 chr17:37824526 PNMT 0.47 6.52 0.34 2.6200000000000003e-10 Asthma; LUSC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.2 0.37 4.12e-12 Mean platelet volume; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg12432903 chr7:1882776 MAD1L1 -0.36 -5.8 -0.3 1.51e-8 Bipolar disorder and schizophrenia; LUSC cis rs13089785 1.000 rs13089785 chr3:123653909 A/C cg01860459 chr3:123419554 MYLK 0.35 5.99 0.31 5.29e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg25036284 chr2:26402008 FAM59B 0.77 10.97 0.51 3.94e-24 Gut microbiome composition (summer); LUSC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.4 -0.38 1.09e-12 Menarche (age at onset); LUSC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg06636001 chr8:8085503 FLJ10661 -0.63 -9.35 -0.46 1.3e-18 Neuroticism; LUSC cis rs2477686 0.526 rs12042427 chr1:2398107 C/T cg07700843 chr1:2391317 NA -0.47 -7.11 -0.36 7.05e-12 Non-obstructive azoospermia; LUSC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.82 0.78 4.1e-70 Prudent dietary pattern; LUSC cis rs7091068 0.706 rs4919398 chr10:95429162 C/T cg20715218 chr10:95462985 C10orf4 0.61 6.41 0.33 5.01e-10 Urinary tract infection frequency; LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg15147215 chr3:52552868 STAB1 -0.34 -6.75 -0.35 6.49e-11 Bipolar disorder; LUSC cis rs910316 0.836 rs6574212 chr14:75671659 G/A cg08847533 chr14:75593920 NEK9 -0.76 -13.11 -0.58 5.7e-32 Height; LUSC cis rs4969178 1.000 rs7212201 chr17:76393896 C/A cg20026190 chr17:76395443 PGS1 0.45 8.06 0.4 1.35e-14 HDL cholesterol levels; LUSC cis rs9326248 0.559 rs10892052 chr11:116834313 G/A cg26566898 chr11:117069891 TAGLN 0.35 6.6 0.34 1.63e-10 Blood protein levels; LUSC cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.56 9.53 0.46 3.4e-19 IgG glycosylation; LUSC cis rs10504229 0.516 rs58244172 chr8:57987805 G/A cg21724239 chr8:58056113 NA 0.42 5.64 0.3 3.55e-8 Developmental language disorder (linguistic errors); LUSC cis rs25645 0.830 rs3935281 chr17:38188419 C/T cg17467752 chr17:38218738 THRA -0.56 -7.9 -0.4 4.13e-14 Myeloid white cell count; LUSC cis rs1577917 0.739 rs6922 chr6:86205323 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.49 0.42 6.73e-16 Response to antipsychotic treatment; LUSC cis rs12545109 0.800 rs2576592 chr8:57419357 A/C cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC trans rs800082 0.668 rs6805395 chr3:144292116 T/C cg24215973 chr2:240111563 HDAC4 -0.61 -9.81 -0.47 3.99e-20 Smoking behavior; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg21782813 chr7:2030301 MAD1L1 0.36 5.84 0.3 1.27e-8 Bipolar disorder and schizophrenia; LUSC cis rs2346177 0.513 rs1530625 chr2:46658067 C/T cg02822958 chr2:46747628 ATP6V1E2 0.42 7.32 0.37 1.83e-12 HDL cholesterol; LUSC cis rs8014204 0.836 rs11159099 chr14:75235397 A/G cg06637938 chr14:75390232 RPS6KL1 0.66 10.94 0.51 5.23e-24 Caffeine consumption; LUSC cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg06784218 chr1:46089804 CCDC17 0.53 10.47 0.5 2.31e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.35 -0.42 1.88e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg05528280 chr10:464225 DIP2C 0.39 6.0 0.31 5.14e-9 Psychosis in Alzheimer's disease; LUSC cis rs9467773 0.565 rs6925047 chr6:26521435 C/G cg09904177 chr6:26538194 HMGN4 0.57 8.91 0.44 3.43e-17 Intelligence (multi-trait analysis); LUSC cis rs72627509 0.904 rs12645070 chr4:57770106 G/A cg26694713 chr4:57773883 REST 0.52 6.38 0.33 6.01e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg05283184 chr6:79620031 NA -0.58 -12.2 -0.56 1.43e-28 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 9.03 0.44 1.36e-17 Menopause (age at onset); LUSC trans rs1814175 0.817 rs10839318 chr11:49657511 G/C cg03929089 chr4:120376271 NA -1.02 -19.42 -0.73 9.06e-57 Height; LUSC cis rs7605827 0.930 rs11687986 chr2:15591308 G/T cg19274914 chr2:15703543 NA 0.46 8.91 0.44 3.37e-17 Educational attainment (years of education); LUSC cis rs10782582 0.609 rs56159153 chr1:76353498 T/G cg03433033 chr1:76189801 ACADM -0.4 -6.01 -0.31 4.82e-9 Daytime sleep phenotypes; LUSC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg18876405 chr7:65276391 NA -0.55 -8.85 -0.44 5.17e-17 Aortic root size; LUSC cis rs2191566 1.000 rs2356549 chr19:44511202 A/T cg03039196 chr19:44506973 ZNF230 0.36 5.89 0.31 9.44e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs6563842 0.528 rs56340348 chr13:41296371 C/T cg21288729 chr13:41239152 FOXO1 0.53 7.97 0.4 2.47e-14 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg07414643 chr4:187882934 NA -0.54 -10.22 -0.49 1.58e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.72 0.6 2.69e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg09826364 chr7:158789723 NA 0.37 5.83 0.3 1.28e-8 Facial morphology (factor 20); LUSC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg05472934 chr7:22766657 IL6 0.53 8.37 0.42 1.61e-15 Cerebrospinal fluid clusterin levels in APOEe4- carriers; LUSC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg20744362 chr22:50050164 C22orf34 0.39 8.09 0.4 1.13e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9329221 0.905 rs6601451 chr8:10243681 C/G cg21775007 chr8:11205619 TDH -0.55 -8.18 -0.41 5.84e-15 Neuroticism; LUSC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg13319975 chr6:146136371 FBXO30 0.68 9.65 0.47 1.36e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs10464366 0.746 rs12670510 chr7:39142146 A/G cg18850127 chr7:39170497 POU6F2 0.62 9.39 0.46 9.69e-19 IgG glycosylation; LUSC cis rs4363385 0.510 rs10888528 chr1:153050516 A/G cg00922841 chr1:152955080 SPRR1A 0.38 6.41 0.33 5.08e-10 Inflammatory skin disease; LUSC cis rs240764 0.621 rs6925840 chr6:101209386 C/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.39 -0.33 5.5e-10 Neuroticism; LUSC cis rs72634258 0.786 rs7514098 chr1:8177632 G/A cg00042356 chr1:8021962 PARK7 0.57 6.89 0.35 2.81e-11 Inflammatory bowel disease; LUSC cis rs9640161 0.783 rs35435439 chr7:150063534 C/T cg27494647 chr7:150038898 RARRES2 0.44 6.55 0.34 2.15e-10 Blood protein levels;Circulating chemerin levels; LUSC trans rs11098499 0.954 rs3733519 chr4:120423448 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.2 0.41 5.35e-15 Corneal astigmatism; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg14004847 chr7:1930337 MAD1L1 -0.56 -8.83 -0.44 5.88e-17 Bipolar disorder and schizophrenia; LUSC cis rs9650657 0.504 rs6601566 chr8:11042974 G/T cg21775007 chr8:11205619 TDH -0.48 -6.84 -0.35 3.84e-11 Neuroticism; LUSC cis rs7696796 0.761 rs17236871 chr4:183162999 A/G cg04638710 chr4:183167912 NA 0.32 5.83 0.3 1.33e-8 Neuroticism; LUSC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg20203395 chr5:56204925 C5orf35 -0.53 -7.97 -0.4 2.6e-14 Coronary artery disease; LUSC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs2479724 0.935 rs62396748 chr6:41782007 A/G cg17623882 chr6:41773611 USP49 0.64 10.45 0.5 2.55e-22 Menarche (age at onset); LUSC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg21132104 chr15:45694354 SPATA5L1 0.59 8.17 0.41 6.56e-15 Homoarginine levels; LUSC cis rs7208859 0.623 rs55811708 chr17:29104731 G/T cg13385521 chr17:29058706 SUZ12P 0.68 6.74 0.35 7.03e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs28830936 0.934 rs28401754 chr15:42116903 T/C cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.91 -0.31 8.38e-9 Diastolic blood pressure; LUSC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg13535736 chr9:111863775 C9orf5 -0.36 -5.86 -0.31 1.1e-8 Menarche (age at onset); LUSC cis rs10186029 0.509 rs6726540 chr2:213943754 A/G cg08319019 chr2:214017104 IKZF2 -0.42 -6.07 -0.32 3.5e-9 Systemic sclerosis; LUSC cis rs7843479 0.965 rs13269198 chr8:21823025 G/A cg17168535 chr8:21777572 XPO7 0.68 10.43 0.5 3.22e-22 Mean corpuscular volume; LUSC cis rs7945718 0.810 rs10831910 chr11:12830974 A/G cg25843174 chr11:12811716 TEAD1 -0.31 -7.17 -0.37 4.89e-12 Educational attainment (years of education); LUSC trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg15556689 chr8:8085844 FLJ10661 0.53 7.66 0.39 2.01e-13 Neuroticism; LUSC cis rs10193935 0.901 rs10170082 chr2:42623452 T/C cg27598129 chr2:42591480 NA -0.61 -8.21 -0.41 4.96e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9814567 0.964 rs6776203 chr3:134234345 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.7 -0.6 3.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.49e-10 Extrinsic epigenetic age acceleration; LUSC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg18402987 chr7:1209562 NA 0.43 5.66 0.3 3.2e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs16910800 0.731 rs56067480 chr11:23190184 C/T cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC trans rs73228161 1.000 rs17022333 chr12:94662928 C/G cg27125177 chr10:85956635 PCDH21 0.5 6.16 0.32 2.12e-9 Major depressive disorder; LUSC trans rs2018683 0.745 rs917217 chr7:28975025 G/T cg19402173 chr7:128379420 CALU 0.49 7.68 0.39 1.75e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs6545883 0.965 rs6545872 chr2:61724568 G/A cg15711740 chr2:61764176 XPO1 -0.5 -7.85 -0.39 5.89e-14 Tuberculosis; LUSC cis rs67478160 0.643 rs6576005 chr14:104292369 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 8.51 0.42 5.83e-16 Schizophrenia; LUSC cis rs8014204 0.816 rs10083386 chr14:75347585 C/A cg06637938 chr14:75390232 RPS6KL1 -0.55 -8.78 -0.43 8.82e-17 Caffeine consumption; LUSC cis rs963731 0.649 rs3765058 chr2:39189636 A/G cg04010122 chr2:39346883 SOS1 0.77 5.71 0.3 2.51e-8 Corticobasal degeneration; LUSC cis rs7781370 1.000 rs6465508 chr7:96127355 A/G cg00604640 chr7:96133485 NA 0.33 5.7 0.3 2.65e-8 Bone mineral density (hip); LUSC cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg00071950 chr4:10020882 SLC2A9 -0.58 -9.55 -0.46 2.92e-19 Bone mineral density; LUSC cis rs1797081 0.967 rs780633 chr10:16863161 C/T cg23933602 chr10:16859644 RSU1 1.09 25.33 0.81 9.94e-80 Platelet distribution width; LUSC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg08847533 chr14:75593920 NEK9 -0.8 -13.67 -0.6 4.14e-34 Height; LUSC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg22920501 chr2:26401640 FAM59B -0.76 -10.62 -0.5 7.07e-23 Gut microbiome composition (summer); LUSC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg26384229 chr12:38710491 ALG10B 0.64 10.05 0.48 6.19e-21 Morning vs. evening chronotype; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg11494091 chr17:61959527 GH2 0.64 13.57 0.6 1e-33 Prudent dietary pattern; LUSC cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 5.71 0.3 2.47e-8 Calcium levels; LUSC cis rs7577696 0.924 rs7605242 chr2:32324135 G/A cg02381751 chr2:32503542 YIPF4 -0.4 -5.76 -0.3 1.87e-8 Inflammatory biomarkers; LUSC cis rs61990749 0.597 rs176946 chr14:78178439 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.62 6.66 0.34 1.11e-10 Fibroblast growth factor basic levels; LUSC cis rs1152591 0.562 rs872227 chr14:64656165 T/C cg21174375 chr14:64681225 SYNE2 0.34 6.25 0.32 1.25e-9 Atrial fibrillation; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs7582180 0.564 rs2309795 chr2:100954290 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.35 -0.42 1.81e-15 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.608 rs12734937 chr1:16047726 T/C cg17385448 chr1:15911702 AGMAT 0.36 5.86 0.31 1.1e-8 Systolic blood pressure; LUSC cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg09184832 chr6:79620586 NA -0.45 -7.3 -0.37 2.18e-12 Intelligence (multi-trait analysis); LUSC cis rs2050392 0.624 rs303436 chr10:30731893 G/T cg18806716 chr10:30721971 MAP3K8 -0.7 -11.53 -0.53 4.04e-26 Inflammatory bowel disease; LUSC trans rs11165623 0.792 rs6671371 chr1:96977039 A/G cg10631902 chr5:14652156 NA -0.44 -6.7 -0.34 8.83e-11 Hip circumference;Waist circumference; LUSC trans rs1945213 0.694 rs12422168 chr11:55866840 A/G cg03929089 chr4:120376271 NA 0.68 7.63 0.39 2.56e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03992926 chr1:186344761 TPR;C1orf27;MIR548F1 -0.54 -7.19 -0.37 4.3e-12 Bipolar disorder and schizophrenia; LUSC cis rs10489202 1.000 rs11587594 chr1:167989180 A/T cg24449463 chr1:168025552 DCAF6 -0.61 -7.78 -0.39 9.31e-14 Schizophrenia; LUSC cis rs6977660 0.714 rs6954046 chr7:19820388 G/A cg05791153 chr7:19748676 TWISTNB 0.64 6.81 0.35 4.49e-11 Thyroid stimulating hormone; LUSC cis rs6028335 0.674 rs16987712 chr20:37601243 A/G cg27552599 chr20:37590471 DHX35 0.45 5.7 0.3 2.59e-8 Alcohol and nicotine co-dependence; LUSC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg03060546 chr3:49711283 APEH -0.56 -8.4 -0.42 1.26e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9640161 0.830 rs35840727 chr7:150063204 A/G cg10018233 chr7:150070692 REPIN1 0.4 7.2 0.37 4.08e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs3540 0.512 rs11633872 chr15:91080512 G/A cg22089800 chr15:90895588 ZNF774 -0.64 -9.62 -0.47 1.67e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs11122272 0.735 rs2009873 chr1:231499236 C/T cg06096015 chr1:231504339 EGLN1 0.56 9.99 0.48 9.69e-21 Hemoglobin concentration; LUSC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg18512352 chr11:47633146 NA -0.46 -9.21 -0.45 3.73e-18 Subjective well-being; LUSC cis rs1728785 1.000 rs1099296 chr16:68588653 G/A cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.4e-10 Ulcerative colitis; LUSC cis rs6580649 1.000 rs7132668 chr12:48405860 C/T cg24011408 chr12:48396354 COL2A1 0.52 7.05 0.36 1.02e-11 Lung cancer; LUSC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.62e-9 Aortic root size; LUSC cis rs3740540 0.507 rs2362500 chr10:126290431 T/C cg04949429 chr10:126290192 LHPP 0.36 7.65 0.39 2.17e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg23625390 chr15:77176239 SCAPER 0.5 7.68 0.39 1.77e-13 Blood metabolite levels; LUSC cis rs554111 0.634 rs34740989 chr1:21316782 C/T cg01072550 chr1:21505969 NA 0.41 6.28 0.32 1.05e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs9788682 0.747 rs2915695 chr15:78739471 T/C cg06917634 chr15:78832804 PSMA4 0.49 5.99 0.31 5.35e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg03517284 chr6:25882590 NA -0.44 -7.59 -0.38 3.12e-13 Intelligence (multi-trait analysis); LUSC cis rs7605827 0.930 rs2111456 chr2:15560118 A/G cg19274914 chr2:15703543 NA 0.47 9.17 0.45 5.11e-18 Educational attainment (years of education); LUSC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9747201 0.963 rs4789729 chr17:80146089 G/A cg18209359 chr17:80159595 CCDC57 -0.41 -6.9 -0.35 2.61e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg06600287 chr1:53387719 ECHDC2 -0.28 -5.74 -0.3 2.11e-8 Monocyte count; LUSC cis rs2439831 0.681 rs524527 chr15:43599116 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -1.06 -15.0 -0.63 3.03e-39 Lung cancer in ever smokers; LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg04944784 chr2:26401820 FAM59B -0.77 -11.41 -0.53 1.12e-25 Gut microbiome composition (summer); LUSC trans rs877282 0.891 rs34652870 chr10:772218 T/C cg22713356 chr15:30763199 NA 1.11 15.31 0.64 1.94e-40 Uric acid levels; LUSC cis rs1371867 0.875 rs7830342 chr8:101327738 T/A cg06636551 chr8:101224915 SPAG1 -0.39 -7.27 -0.37 2.64e-12 Atrioventricular conduction; LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg25036284 chr2:26402008 FAM59B -0.73 -10.66 -0.5 4.85e-23 Gut microbiome composition (summer); LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg14004847 chr7:1930337 MAD1L1 -0.51 -7.51 -0.38 5.38e-13 Bipolar disorder and schizophrenia; LUSC cis rs73001065 0.901 rs10401969 chr19:19407718 A/G cg03709012 chr19:19516395 GATAD2A 0.79 6.48 0.33 3.33e-10 LDL cholesterol; LUSC cis rs17270561 0.608 rs9358875 chr6:25738008 G/A cg17691542 chr6:26056736 HIST1H1C 0.56 7.72 0.39 1.34e-13 Iron status biomarkers; LUSC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg04369109 chr6:150039330 LATS1 -0.56 -8.24 -0.41 3.94e-15 Lung cancer; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg07362569 chr17:61921086 SMARCD2 0.37 7.78 0.39 9.34e-14 Prudent dietary pattern; LUSC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg08847533 chr14:75593920 NEK9 0.5 7.25 0.37 2.87e-12 Caffeine consumption; LUSC cis rs10392 0.571 rs6015982 chr20:37534369 C/T cg27552599 chr20:37590471 DHX35 0.44 6.98 0.36 1.63e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs4285028 0.848 rs4118376 chr3:121636450 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.74 -0.47 7.02e-20 Multiple sclerosis; LUSC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg11812906 chr14:75593930 NEK9 -0.64 -10.93 -0.51 5.65e-24 Height; LUSC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg07061783 chr6:25882402 NA 0.43 6.06 0.31 3.6e-9 Blood metabolite levels; LUSC cis rs1065656 0.589 rs391543 chr16:1915583 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.43 6.23 0.32 1.37e-9 Insulin-like growth factors; LUSC cis rs2050392 0.965 rs2480279 chr10:30700032 C/T cg18806716 chr10:30721971 MAP3K8 -0.48 -7.94 -0.4 3.05e-14 Inflammatory bowel disease; LUSC cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg06022373 chr22:39101656 GTPBP1 -0.74 -11.34 -0.53 1.9e-25 Menopause (age at onset); LUSC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg04727924 chr7:799746 HEATR2 -0.55 -6.67 -0.34 1.07e-10 Cerebrospinal P-tau181p levels; LUSC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.82 12.15 0.55 2.23e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg17509989 chr5:176798049 RGS14 0.67 10.3 0.49 8.84e-22 Urinary electrolytes (magnesium/calcium ratio); LUSC cis rs13089785 0.965 rs12493045 chr3:123620718 C/A cg19611163 chr3:123411211 MYLK 0.34 5.81 0.3 1.45e-8 Intelligence (multi-trait analysis); LUSC cis rs7177699 0.557 rs12442476 chr15:79117856 G/A cg15571903 chr15:79123663 NA 0.32 5.9 0.31 9.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs765787 0.530 rs12910270 chr15:45512086 G/A cg25801113 chr15:45476975 SHF -0.34 -6.7 -0.34 8.69e-11 Uric acid levels; LUSC cis rs9303280 0.806 rs8069176 chr17:38057197 G/A cg20243544 chr17:37824526 PNMT 0.41 6.13 0.32 2.49e-9 Self-reported allergy; LUSC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.81 0.65 1.94e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11105298 0.891 rs10858902 chr12:89927789 A/G cg00757033 chr12:89920650 WDR51B 0.6 10.53 0.5 1.42e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19988671 chr7:155589783 NA 0.44 6.88 0.35 2.9e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1371867 0.846 rs1788203 chr8:101303721 T/C cg00191853 chr8:101177733 SPAG1 -0.41 -6.56 -0.34 2.08e-10 Atrioventricular conduction; LUSC trans rs4927850 0.666 rs4927853 chr3:195752053 G/C cg21051086 chr3:73046214 PPP4R2 -0.52 -7.79 -0.39 8.38e-14 Pancreatic cancer; LUSC cis rs1595825 0.891 rs60484833 chr2:198812181 C/T cg00982548 chr2:198649783 BOLL -0.56 -7.07 -0.36 9.23e-12 Ulcerative colitis; LUSC cis rs13266463 0.898 rs13267784 chr8:143394915 C/T cg16886403 chr8:143471632 TSNARE1 0.62 8.95 0.44 2.55e-17 Schizophrenia; LUSC cis rs11122272 0.735 rs2739506 chr1:231529183 T/G cg06096015 chr1:231504339 EGLN1 0.57 10.12 0.48 3.69e-21 Hemoglobin concentration; LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg11645453 chr3:52864694 ITIH4 -0.49 -11.02 -0.52 2.62e-24 Schizophrenia; LUSC cis rs73206853 0.841 rs56887341 chr12:110947185 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.5 0.38 5.91e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg02569458 chr12:86230093 RASSF9 0.54 9.21 0.45 3.78e-18 Major depressive disorder; LUSC trans rs71435601 0.628 rs478442 chr2:21399216 A/C cg20757404 chr19:378427 NA -0.38 -6.09 -0.32 3.09e-9 Cholesterol, total; LUSC cis rs9952991 0.941 rs2542151 chr18:12779947 G/T cg23544223 chr18:12777786 NA 0.6 6.07 0.32 3.55e-9 Inflammatory skin disease; LUSC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg13798780 chr7:105162888 PUS7 0.55 6.08 0.32 3.27e-9 Bipolar disorder (body mass index interaction); LUSC trans rs6502050 0.835 rs62078306 chr17:80085341 A/G cg07393940 chr7:158741817 NA -0.37 -6.7 -0.34 8.85e-11 Life satisfaction; LUSC cis rs1801251 0.778 rs2592115 chr2:233736349 C/T cg25237894 chr2:233734115 C2orf82 -0.32 -5.96 -0.31 6.26e-9 Coronary artery disease; LUSC cis rs4851254 0.961 rs11677607 chr2:100751150 C/T cg07810366 chr2:100720526 AFF3 -0.38 -5.91 -0.31 8.42e-9 Intelligence (multi-trait analysis); LUSC cis rs6835098 0.828 rs28612521 chr4:174085294 G/A cg08422745 chr4:174089978 GALNT7 -0.85 -13.98 -0.61 2.67e-35 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg19678392 chr7:94953810 PON1 -0.6 -12.13 -0.55 2.69e-28 Paraoxonase activity; LUSC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11890956 chr21:40555474 PSMG1 1.03 20.82 0.75 2.6e-62 Cognitive function; LUSC cis rs672059 0.934 rs6703054 chr1:183155778 A/C ch.1.3577855R chr1:183094577 LAMC1 0.58 8.49 0.42 6.74e-16 Hypertriglyceridemia; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs7824557 0.707 rs3808518 chr8:11143272 A/C cg27411982 chr8:10470053 RP1L1 -0.39 -6.22 -0.32 1.45e-9 Retinal vascular caliber; LUSC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg16797656 chr11:68205561 LRP5 -0.42 -7.81 -0.39 7.39e-14 Total body bone mineral density; LUSC cis rs7107174 1.000 rs2512547 chr11:77960888 T/C cg02023728 chr11:77925099 USP35 0.45 6.71 0.34 8.46e-11 Testicular germ cell tumor; LUSC cis rs9640161 0.659 rs7788316 chr7:150013995 A/T cg21361702 chr7:150065534 REPIN1 0.45 6.26 0.32 1.16e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6964587 0.967 rs7786031 chr7:91649001 T/G cg22117172 chr7:91764530 CYP51A1 0.31 5.7 0.3 2.7e-8 Breast cancer; LUSC cis rs870825 0.616 rs57271221 chr4:185627198 C/T cg04058563 chr4:185651563 MLF1IP 0.88 12.51 0.56 1.04e-29 Blood protein levels; LUSC cis rs4141404 0.851 rs5997893 chr22:31556103 A/G cg13145458 chr22:31556086 RNF185 0.45 5.91 0.31 8.37e-9 Paclitaxel-induced neuropathy; LUSC cis rs10769945 0.679 rs7105710 chr11:1918083 T/C cg26856596 chr11:1961893 NA 0.32 6.18 0.32 1.88e-9 DNA methylation (variation); LUSC cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.37 -0.46 1.09e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg08067268 chr2:26466485 HADHB;HADHA 0.58 8.69 0.43 1.67e-16 Gut microbiome composition (summer); LUSC cis rs3768617 0.510 rs10752903 chr1:183100863 A/G ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC cis rs10465746 0.967 rs942849 chr1:84427499 G/A cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.01e-9 Obesity-related traits; LUSC cis rs6701037 1.000 rs6681020 chr1:175125264 G/A cg17845761 chr1:175162550 KIAA0040 -0.31 -6.0 -0.31 5.07e-9 Alcohol dependence; LUSC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg10802521 chr3:52805072 NEK4 -0.53 -8.55 -0.42 4.44e-16 Bipolar disorder; LUSC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -8.46 -0.42 8.5e-16 Personality dimensions; LUSC cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg07148914 chr20:33460835 GGT7 0.45 6.68 0.34 9.92e-11 Height; LUSC trans rs853679 1.000 rs11965538 chr6:28239915 G/A cg01620082 chr3:125678407 NA -0.51 -6.04 -0.31 4.06e-9 Depression; LUSC cis rs897080 0.515 rs1067336 chr2:44625876 G/A cg00619915 chr2:44497795 NA -0.4 -5.66 -0.3 3.29e-8 Height; LUSC cis rs1348850 0.514 rs4893974 chr2:178497026 A/G cg22681709 chr2:178499509 PDE11A -0.51 -7.52 -0.38 5.05e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs2262909 0.889 rs61268244 chr19:22310130 C/T cg05197062 chr11:11642011 GALNTL4 0.55 7.77 0.39 1.01e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg02012338 chr4:187126139 CYP4V2 -0.63 -5.83 -0.3 1.32e-8 Blood protein levels; LUSC cis rs2760061 0.545 rs1636196 chr1:228204030 A/G cg18477163 chr1:228402036 OBSCN 0.57 9.57 0.46 2.54e-19 Diastolic blood pressure; LUSC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg24531977 chr5:56204891 C5orf35 -1.05 -15.45 -0.65 5.46e-41 Initial pursuit acceleration; LUSC cis rs62400317 0.762 rs12208332 chr6:44903221 C/T cg18551225 chr6:44695536 NA -0.48 -7.71 -0.39 1.51e-13 Total body bone mineral density; LUSC cis rs7824557 0.564 rs12550129 chr8:11233917 C/T cg21775007 chr8:11205619 TDH -0.67 -10.66 -0.5 5.14e-23 Retinal vascular caliber; LUSC trans rs11098499 0.908 rs12504149 chr4:120318577 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.22 0.32 1.49e-9 Corneal astigmatism; LUSC cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg17261708 chr5:176794207 RGS14 0.34 5.94 0.31 7.05e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg26384229 chr12:38710491 ALG10B 0.88 14.84 0.63 1.28e-38 Bladder cancer; LUSC cis rs1949733 1.000 rs6447875 chr4:8503206 T/C cg11789530 chr4:8429930 ACOX3 0.61 9.23 0.45 3.17e-18 Response to antineoplastic agents; LUSC cis rs72781680 1.000 rs61739076 chr2:24149439 G/A cg20701182 chr2:24300061 SF3B14 0.77 7.73 0.39 1.25e-13 Lymphocyte counts; LUSC cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg00071950 chr4:10020882 SLC2A9 0.67 11.22 0.52 5.3e-25 Bone mineral density; LUSC cis rs1865760 0.865 rs9393678 chr6:25945819 C/T cg16482183 chr6:26056742 HIST1H1C 0.47 6.96 0.36 1.85e-11 Height; LUSC trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs208520 0.690 rs207096 chr6:66797287 T/C cg07460842 chr6:66804631 NA -1.14 -18.17 -0.71 8.4e-52 Exhaled nitric oxide output; LUSC trans rs4942242 0.740 rs6561137 chr13:44231965 A/T cg19169023 chr15:41853346 TYRO3 -0.37 -6.22 -0.32 1.47e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg13560548 chr3:10150139 C3orf24 0.52 7.18 0.37 4.45e-12 Alzheimer's disease; LUSC cis rs6546550 0.901 rs7598283 chr2:70128717 A/G cg02498382 chr2:70120550 SNRNP27 -0.29 -7.29 -0.37 2.2e-12 Prevalent atrial fibrillation; LUSC cis rs7739264 0.564 rs760796 chr6:19790387 C/T cg02404759 chr6:19790362 NA -0.44 -6.9 -0.35 2.63e-11 Endometriosis; LUSC cis rs2295359 0.892 rs2064689 chr1:67653010 G/A cg17031739 chr1:67600172 NA 0.46 7.11 0.36 7e-12 Psoriasis; LUSC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg22903471 chr2:27725779 GCKR -0.4 -6.83 -0.35 3.97e-11 Total body bone mineral density; LUSC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg04944784 chr2:26401820 FAM59B 0.66 7.96 0.4 2.73e-14 Gut microbiome composition (summer); LUSC cis rs6964587 0.934 rs7811328 chr7:91720931 A/T cg01689657 chr7:91764605 CYP51A1 0.31 5.65 0.3 3.48e-8 Breast cancer; LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC trans rs1814175 0.817 rs7924619 chr11:49620632 G/A cg03929089 chr4:120376271 NA -1.01 -19.18 -0.72 8.42e-56 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16715692 chr19:1104863 GPX4 -0.41 -6.04 -0.31 4.14e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2637266 0.935 rs2579771 chr10:78407544 A/G cg18941641 chr10:78392320 NA 0.41 7.37 0.37 1.34e-12 Pulmonary function; LUSC cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg11244672 chr19:19639970 YJEFN3 -0.58 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04479987 chr5:180649488 TRIM41 0.39 6.03 0.31 4.24e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs924607 0.931 rs1709556 chr5:637058 A/G cg09021430 chr5:549028 NA -0.42 -7.49 -0.38 6.29e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs1403694 0.695 rs3821815 chr3:186434262 A/G cg12454167 chr3:186435060 KNG1 0.32 7.82 0.39 7.04e-14 Blood protein levels; LUSC cis rs9311676 0.656 rs10866016 chr3:58390844 C/T cg13750441 chr3:58318267 PXK 0.35 6.84 0.35 3.85e-11 Systemic lupus erythematosus; LUSC cis rs2227564 0.645 rs2633309 chr10:75654086 G/A cg23231163 chr10:75533350 FUT11 -0.43 -6.16 -0.32 2.13e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18404041 chr3:52824283 ITIH1 -0.51 -9.86 -0.47 2.61e-20 Bipolar disorder; LUSC cis rs77633900 0.614 rs2439984 chr15:76923917 T/C cg21673338 chr15:77095150 SCAPER -0.74 -7.31 -0.37 1.99e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg11871910 chr12:69753446 YEATS4 0.65 9.94 0.48 1.49e-20 Blood protein levels; LUSC trans rs1499614 0.831 rs3800822 chr7:66147149 A/G cg10756647 chr7:56101905 PSPH -0.85 -8.45 -0.42 8.99e-16 Gout; LUSC cis rs920590 0.684 rs59259846 chr8:19669468 C/G cg03894339 chr8:19674705 INTS10 0.58 7.9 0.4 4.05e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg02782426 chr3:40428986 ENTPD3 0.32 6.03 0.31 4.42e-9 Renal cell carcinoma; LUSC cis rs2235642 0.750 rs2859310 chr16:1656765 C/T cg26528668 chr16:1614120 IFT140 -0.41 -7.01 -0.36 1.29e-11 Coronary artery disease; LUSC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg13683864 chr3:40499215 RPL14 0.93 16.26 0.66 3.44e-44 Renal cell carcinoma; LUSC cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg23791538 chr6:167370224 RNASET2 -0.36 -5.72 -0.3 2.36e-8 Crohn's disease; LUSC cis rs12681287 0.640 rs6471314 chr8:87400459 G/A cg27223183 chr8:87520930 FAM82B 0.55 7.43 0.38 9.34e-13 Caudate activity during reward; LUSC cis rs1011108 1.000 rs1011108 chr2:26782621 A/G cg18742855 chr2:26800399 C2orf70 -0.37 -6.71 -0.34 8.38e-11 Periodontal microbiota; LUSC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg04871131 chr7:94954202 PON1 -0.38 -6.06 -0.31 3.74e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6964587 0.655 rs6465351 chr7:91773213 T/C cg17063962 chr7:91808500 NA 0.58 9.75 0.47 6.46e-20 Breast cancer; LUSC cis rs9747201 0.832 rs4072580 chr17:80160337 A/C cg17462356 chr17:80056334 FASN -0.45 -6.17 -0.32 1.97e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6977660 0.714 rs13225018 chr7:19816567 C/T cg05791153 chr7:19748676 TWISTNB 0.69 7.28 0.37 2.35e-12 Thyroid stimulating hormone; LUSC cis rs1670533 1.000 rs11247972 chr4:1060550 A/G cg27284194 chr4:1044797 NA 0.59 8.61 0.43 3.01e-16 Recombination rate (females); LUSC cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg22875332 chr1:76189707 ACADM -0.39 -5.85 -0.3 1.19e-8 Daytime sleep phenotypes; LUSC cis rs1595825 1.000 rs56765024 chr2:198876286 G/T cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs13427251 0.692 rs17765112 chr2:100149336 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.69 -0.34 9.49e-11 Chronic sinus infection; LUSC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg11062466 chr8:58055876 NA 0.7 7.99 0.4 2.19e-14 Developmental language disorder (linguistic errors); LUSC cis rs7208859 0.673 rs9915139 chr17:29158515 A/G cg13385521 chr17:29058706 SUZ12P 0.61 6.31 0.33 9.06e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7246657 0.943 rs4801759 chr19:37954985 G/A cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs9908158 1 rs9908158 chr17:33890083 T/C cg05299278 chr17:33885742 SLFN14 -0.32 -6.78 -0.35 5.32e-11 Platelet count;Platelet distribution width; LUSC cis rs644148 0.676 rs2571114 chr19:44997579 A/G cg15540054 chr19:45004280 ZNF180 -0.51 -7.25 -0.37 2.97e-12 Personality dimensions; LUSC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg22655196 chr4:3374909 RGS12 0.31 5.96 0.31 6.35e-9 Serum sulfate level; LUSC cis rs7113850 0.541 rs78652241 chr11:24234956 A/T ch.11.24196551F chr11:24239977 NA 0.99 9.07 0.44 1.01e-17 Bone fracture in osteoporosis; LUSC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.78 0.35 5.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11608355 0.515 rs7310945 chr12:109946012 G/A cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs453301 0.657 rs36056437 chr8:8792865 T/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.31 -0.37 1.95e-12 Joint mobility (Beighton score); LUSC cis rs1538970 0.962 rs2185549 chr1:45814103 C/T cg05343316 chr1:45956843 TESK2 -0.62 -8.41 -0.42 1.2e-15 Platelet count; LUSC cis rs9303401 0.573 rs34717648 chr17:56886624 T/A cg25039879 chr17:56429692 SUPT4H1 0.67 9.01 0.44 1.6e-17 Cognitive test performance; LUSC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg06219351 chr7:158114137 PTPRN2 0.51 9.16 0.45 5.28e-18 Calcium levels; LUSC cis rs709400 1.000 rs10135248 chr14:104122310 T/C cg24130564 chr14:104152367 KLC1 -0.52 -7.7 -0.39 1.53e-13 Body mass index; LUSC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.62 0.5 6.81e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs727563 0.565 rs132774 chr22:42031953 C/G cg03806693 chr22:41940476 POLR3H -0.82 -10.73 -0.51 2.93e-23 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg06134567 chr22:46658398 PKDREJ -0.54 -6.27 -0.32 1.14e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg01879757 chr17:41196368 BRCA1 -0.45 -6.99 -0.36 1.54e-11 Menopause (age at onset); LUSC cis rs6076065 0.925 rs6083106 chr20:23368809 A/C cg11657817 chr20:23433608 CST11 0.43 8.68 0.43 1.77e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs7223966 1.000 rs11657120 chr17:61857218 G/A cg00945038 chr17:61921165 SMARCD2 0.4 6.03 0.31 4.3e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs11608355 0.521 rs1119271 chr12:109819727 A/T cg19025524 chr12:109796872 NA -0.41 -7.71 -0.39 1.5e-13 Neuroticism; LUSC cis rs8170 0.603 rs8110408 chr19:17440542 C/G cg04749549 chr19:17459798 NA -0.34 -6.11 -0.32 2.75e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC cis rs1775715 0.870 rs1775731 chr10:32253512 A/G cg04359828 chr10:32216031 ARHGAP12 0.38 6.29 0.33 9.91e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1348850 0.554 rs11679519 chr2:178432110 C/T cg23306229 chr2:178417860 TTC30B 0.56 6.38 0.33 5.74e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg15369054 chr17:80825471 TBCD -0.36 -5.9 -0.31 8.93e-9 Breast cancer; LUSC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg25427524 chr10:38739819 LOC399744 -0.65 -11.68 -0.54 1.15e-26 Extrinsic epigenetic age acceleration; LUSC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.86 12.17 0.55 1.96e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg16624210 chr5:671434 TPPP 0.49 6.12 0.32 2.58e-9 Lung disease severity in cystic fibrosis; LUSC cis rs6961069 0.745 rs11770358 chr7:80271330 A/T cg04458919 chr7:80252533 CD36 0.35 6.15 0.32 2.22e-9 Platelet count; LUSC cis rs1348850 0.914 rs6761593 chr2:178451600 A/G cg22681709 chr2:178499509 PDE11A 0.47 8.42 0.42 1.16e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1113500 0.548 rs3853497 chr1:108657184 C/T cg11967332 chr1:108735228 SLC25A24 0.43 5.98 0.31 5.63e-9 Growth-regulated protein alpha levels; LUSC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.38 -6.23 -0.32 1.37e-9 Self-reported allergy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04999148 chr11:65188955 NEAT1 0.44 6.25 0.32 1.28e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9644630 0.897 rs6984644 chr8:19363425 C/T cg01280390 chr8:19363452 CSGALNACT1 0.35 6.64 0.34 1.28e-10 Oropharynx cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04060830 chr9:132816023 GPR107 -0.52 -6.89 -0.35 2.82e-11 Hepatitis; LUSC cis rs7215564 0.908 rs2873060 chr17:78663497 A/C cg09596252 chr17:78655493 RPTOR 0.53 5.85 0.31 1.15e-8 Myopia (pathological); LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg09021430 chr5:549028 NA -0.53 -7.49 -0.38 6.08e-13 Lung disease severity in cystic fibrosis; LUSC trans rs3808502 0.549 rs1382563 chr8:11426790 C/G cg08975724 chr8:8085496 FLJ10661 0.48 7.06 0.36 9.61e-12 Neuroticism; LUSC cis rs7949030 0.504 rs2516633 chr11:62371773 A/C cg22862634 chr11:62369728 EML3;MTA2 -0.49 -7.39 -0.37 1.19e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16684811 chr5:77944851 LHFPL2 -0.51 -7.09 -0.36 8.26e-12 Bipolar disorder and schizophrenia; LUSC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg18876405 chr7:65276391 NA -0.58 -9.36 -0.46 1.22e-18 Aortic root size; LUSC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg16989086 chr20:62203971 PRIC285 0.47 6.64 0.34 1.26e-10 Glioblastoma; LUSC cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg00071950 chr4:10020882 SLC2A9 0.57 9.46 0.46 5.48e-19 Bone mineral density; LUSC cis rs16867321 0.950 rs1919152 chr2:181507765 C/T cg23363182 chr2:181467187 NA -0.45 -5.87 -0.31 1.03e-8 Obesity; LUSC trans rs11098499 0.954 rs2389803 chr4:120393511 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.44 -5.96 -0.31 6.45e-9 Corneal astigmatism; LUSC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg15017067 chr4:17643749 FAM184B 0.36 5.9 0.31 8.95e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.95 0.31 6.78e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11098499 0.775 rs67281037 chr4:120281157 G/C cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.85 0.3 1.2e-8 Lung cancer; LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg07341129 chr10:126685689 CTBP2 0.41 6.31 0.33 8.98e-10 Cognitive function;Information processing speed; LUSC cis rs12594515 1.000 rs8025258 chr15:45987554 C/A cg01629716 chr15:45996671 NA 0.4 6.07 0.32 3.53e-9 Waist circumference;Weight; LUSC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg23711669 chr6:146136114 FBXO30 0.82 14.71 0.63 4.15e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg22166914 chr1:53195759 ZYG11B -0.41 -6.06 -0.31 3.72e-9 Monocyte count; LUSC cis rs8114671 0.836 rs6060165 chr20:33619480 A/C cg07148914 chr20:33460835 GGT7 -0.43 -6.4 -0.33 5.34e-10 Height; LUSC cis rs9467773 0.620 rs1490488 chr6:26614808 T/C cg09904177 chr6:26538194 HMGN4 0.66 11.93 0.55 1.38e-27 Intelligence (multi-trait analysis); LUSC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08704250 chr15:31115839 NA -0.48 -7.05 -0.36 1.03e-11 Huntington's disease progression; LUSC trans rs236907 0.859 rs34320898 chr1:171759139 G/C cg13482142 chr2:234261155 NA 0.51 6.13 0.32 2.46e-9 Mean platelet volume; LUSC cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg13010199 chr12:38710504 ALG10B 0.62 9.55 0.46 2.99e-19 Bladder cancer; LUSC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6696846 0.691 rs11240370 chr1:205118336 T/G cg21643547 chr1:205240462 TMCC2 -0.41 -7.61 -0.38 2.85e-13 Red blood cell count; LUSC cis rs9549367 0.713 rs576463 chr13:113846614 C/T cg00898013 chr13:113819073 PROZ 0.54 8.04 0.4 1.59e-14 Platelet distribution width; LUSC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 11.69 0.54 1.09e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9329221 0.527 rs10903328 chr8:10332167 G/C cg15556689 chr8:8085844 FLJ10661 0.51 7.18 0.37 4.55e-12 Neuroticism; LUSC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); LUSC cis rs6547741 1.000 rs1919126 chr2:27801418 C/A cg12559939 chr2:27858050 GPN1 0.41 6.44 0.33 4.23e-10 Oral cavity cancer; LUSC cis rs1113500 0.933 rs61797344 chr1:108622580 C/T cg11967332 chr1:108735228 SLC25A24 0.39 5.84 0.3 1.22e-8 Growth-regulated protein alpha levels; LUSC cis rs7296418 0.738 rs1568428 chr12:123738876 A/G cg13010344 chr12:123464640 ARL6IP4 0.44 7.15 0.36 5.6e-12 Platelet count; LUSC cis rs9467773 0.525 rs1535274 chr6:26520747 A/C cg09904177 chr6:26538194 HMGN4 0.57 8.91 0.44 3.43e-17 Intelligence (multi-trait analysis); LUSC trans rs10221833 0.602 rs355886 chr2:165634156 G/A cg26993132 chr16:89239499 CDH15 0.32 6.27 0.32 1.15e-9 Response to statin therapy; LUSC cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs4319547 0.656 rs10734918 chr12:122921512 A/C cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.58 -0.43 3.6e-16 Body mass index; LUSC cis rs10484885 0.793 rs9359862 chr6:90474508 A/G cg13799429 chr6:90582589 CASP8AP2 0.92 11.07 0.52 1.86e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7000551 0.751 rs2469770 chr8:22379856 G/A cg12081754 chr8:22256438 SLC39A14 0.46 6.79 0.35 5.12e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg06697600 chr4:7070879 GRPEL1 0.4 5.89 0.31 9.34e-9 Monocyte percentage of white cells; LUSC cis rs8064299 0.584 rs2384957 chr17:72784630 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.9 18.57 0.71 2.26e-53 Monocyte count; LUSC trans rs12310956 0.510 rs10844690 chr12:33854752 C/A cg26384229 chr12:38710491 ALG10B 0.56 8.65 0.43 2.19e-16 Morning vs. evening chronotype; LUSC cis rs7824557 0.527 rs2736296 chr8:11234844 G/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.93 -0.31 7.5e-9 Retinal vascular caliber; LUSC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg20821713 chr7:1055600 C7orf50 -0.5 -6.62 -0.34 1.42e-10 Bronchopulmonary dysplasia; LUSC cis rs72781680 0.898 rs72798049 chr2:23958002 C/G cg08917208 chr2:24149416 ATAD2B 0.88 9.72 0.47 7.6e-20 Lymphocyte counts; LUSC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg11494091 chr17:61959527 GH2 0.39 6.61 0.34 1.48e-10 Height; LUSC cis rs10761482 0.861 rs7096426 chr10:62106545 C/T cg18175470 chr10:62150864 ANK3 0.52 7.46 0.38 7.77e-13 Schizophrenia; LUSC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg26850624 chr5:429559 AHRR -0.4 -7.85 -0.39 5.68e-14 Cystic fibrosis severity; LUSC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg07636037 chr3:49044803 WDR6 1.05 19.36 0.73 1.59e-56 Parkinson's disease; LUSC cis rs6867032 0.527 rs1017924 chr5:1976187 C/T cg26168224 chr5:2018326 NA 0.53 7.81 0.39 7.23e-14 Gut microbiome composition (winter); LUSC cis rs12594515 1.000 rs11070467 chr15:45985001 C/T cg06207120 chr15:45996521 NA -0.4 -6.16 -0.32 2.04e-9 Waist circumference;Weight; LUSC cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg12011299 chr4:100065546 ADH4 -0.71 -11.17 -0.52 7.69e-25 Alcohol dependence; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.85 -0.51 1.12e-23 Alzheimer's disease; LUSC cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg23649088 chr2:200775458 C2orf69 -0.6 -8.62 -0.43 2.7e-16 Schizophrenia; LUSC cis rs13089785 0.725 rs2222822 chr3:123604788 T/A cg01860459 chr3:123419554 MYLK 0.39 6.47 0.33 3.49e-10 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.863 rs1383533 chr4:120434576 G/A cg25214090 chr10:38739885 LOC399744 0.5 7.45 0.38 8.19e-13 Corneal astigmatism; LUSC cis rs9800506 0.835 rs6923449 chr6:35527714 T/C cg03566752 chr6:35512600 NA 0.24 5.81 0.3 1.45e-8 Neutrophil percentage of granulocytes; LUSC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg12365402 chr11:9010492 NRIP3 -0.49 -9.42 -0.46 7.83e-19 Hemoglobin concentration; LUSC cis rs3771570 1.000 rs12619369 chr2:242282957 A/T cg21155796 chr2:242212141 HDLBP 0.58 6.7 0.34 8.91e-11 Prostate cancer; LUSC cis rs11155671 0.517 rs9397058 chr6:150207249 C/T cg09699651 chr6:150184138 LRP11 0.45 7.15 0.36 5.64e-12 Testicular germ cell tumor; LUSC trans rs9388451 0.839 rs11154331 chr6:126111429 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.58 -9.28 -0.45 2.17e-18 Brugada syndrome; LUSC cis rs6881634 0.508 rs10053035 chr5:77652346 C/T cg11547950 chr5:77652471 NA -0.34 -6.39 -0.33 5.51e-10 Hippocampal atrophy; LUSC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11644478 chr21:40555479 PSMG1 0.87 15.36 0.64 1.18e-40 Cognitive function; LUSC cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg09988129 chr7:74988866 PMS2L2;STAG3L1 -0.38 -5.73 -0.3 2.26e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2439831 0.850 rs2228368 chr15:44102010 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.71 6.64 0.34 1.3e-10 Lung cancer in ever smokers; LUSC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg24562669 chr7:97807699 LMTK2 0.34 6.01 0.31 4.91e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7254114 0.578 rs12980863 chr19:11309871 C/T cg02815516 chr19:11306319 KANK2 -0.41 -8.42 -0.42 1.09e-15 Immature fraction of reticulocytes; LUSC cis rs11025559 0.796 rs11603462 chr11:20412180 C/A cg19653624 chr11:20408972 PRMT3 -0.67 -8.55 -0.42 4.38e-16 Pursuit maintenance gain; LUSC cis rs524023 1.000 rs12786214 chr11:64364203 G/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.24 -0.49 1.38e-21 Urate levels in obese individuals; LUSC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg26380479 chr7:97908229 NA 0.26 5.89 0.31 9.58e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg27535305 chr1:53392650 SCP2 -0.44 -8.91 -0.44 3.44e-17 Monocyte count; LUSC cis rs7917772 0.582 rs7906115 chr10:104327164 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs75804782 0.691 rs55886641 chr2:239319185 T/C cg01134436 chr17:81009848 B3GNTL1 0.64 6.08 0.32 3.37e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg25456477 chr12:86230367 RASSF9 0.43 7.65 0.39 2.18e-13 Major depressive disorder; LUSC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg27529037 chr20:44575021 PCIF1 0.4 7.06 0.36 9.45e-12 Intelligence (multi-trait analysis); LUSC cis rs61931739 0.635 rs7979207 chr12:33910566 C/T cg06521331 chr12:34319734 NA 0.42 6.97 0.36 1.7e-11 Morning vs. evening chronotype; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.51 0.42 6.06e-16 Prudent dietary pattern; LUSC cis rs2288073 0.965 rs10185445 chr2:24410976 A/C cg06627628 chr2:24431161 ITSN2 0.7 9.46 0.46 5.61e-19 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs11122272 0.706 rs2749710 chr1:231535112 A/C cg06096015 chr1:231504339 EGLN1 -0.56 -9.93 -0.48 1.61e-20 Hemoglobin concentration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05904194 chr2:85132663 TMSB10 -0.41 -6.23 -0.32 1.4e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.63 0.85 1.69e-95 Chronic sinus infection; LUSC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg06713675 chr4:122721982 EXOSC9 -0.46 -8.14 -0.41 8e-15 Type 2 diabetes; LUSC trans rs9944715 1.000 rs718514 chr18:43856354 A/C cg01718231 chr17:29326311 RNF135 -0.52 -7.29 -0.37 2.32e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg02527881 chr3:46936655 PTH1R 0.4 7.0 0.36 1.41e-11 Colorectal cancer; LUSC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg08847533 chr14:75593920 NEK9 -0.82 -14.82 -0.63 1.58e-38 Height; LUSC cis rs2361718 0.967 rs12942941 chr17:78103013 C/T cg21238619 chr17:78079768 GAA -0.29 -5.95 -0.31 6.59e-9 Yeast infection; LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg03909863 chr11:638404 DRD4 -0.43 -6.14 -0.32 2.4e-9 Systemic lupus erythematosus; LUSC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg12560992 chr17:57184187 TRIM37 -0.84 -15.23 -0.64 3.72e-40 Intelligence (multi-trait analysis); LUSC cis rs977987 0.778 rs7206541 chr16:75436713 A/T cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.8e-17 Dupuytren's disease; LUSC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg22823121 chr1:150693482 HORMAD1 0.51 7.49 0.38 6.11e-13 Melanoma; LUSC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.87 -0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg23260525 chr10:116636907 FAM160B1 0.49 10.57 0.5 1.05e-22 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2115630 0.755 rs7169629 chr15:85191274 C/G cg11189052 chr15:85197271 WDR73 0.53 8.14 0.41 8.09e-15 P wave terminal force; LUSC cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg04369109 chr6:150039330 LATS1 -0.54 -7.82 -0.39 7.05e-14 Lung cancer; LUSC cis rs1372520 0.873 rs2736989 chr4:90776257 T/C cg01966878 chr4:90757139 SNCA -0.4 -5.72 -0.3 2.38e-8 Neuroticism; LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.71 11.36 0.53 1.73e-25 Prudent dietary pattern; LUSC cis rs7929679 0.551 rs10466455 chr11:34780936 C/T cg06937548 chr11:34938143 PDHX;APIP -0.41 -6.03 -0.31 4.31e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs6542838 0.641 rs11123756 chr2:99508012 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.45 5.94 0.31 7.2e-9 Fear of minor pain; LUSC trans rs931812 0.825 rs13271753 chr8:101895491 T/C cg20993868 chr7:22813445 NA 0.59 10.34 0.49 6.19e-22 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs6500602 0.893 rs6500598 chr16:4470964 G/T cg08645402 chr16:4508243 NA 0.51 8.12 0.41 9.29e-15 Schizophrenia; LUSC cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs9300255 0.602 rs11057192 chr12:123693420 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC trans rs1998174 0.509 rs10798695 chr1:171812059 A/G cg13482142 chr2:234261155 NA 0.42 6.02 0.31 4.51e-9 Platelet distribution width; LUSC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg00310523 chr12:86230176 RASSF9 0.42 7.56 0.38 4.01e-13 Major depressive disorder; LUSC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg18190219 chr22:46762943 CELSR1 -0.48 -5.95 -0.31 6.67e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg25767906 chr1:53392781 SCP2 -0.5 -9.21 -0.45 3.66e-18 Monocyte count; LUSC cis rs3820068 0.705 rs58424111 chr1:15868470 A/C cg17385448 chr1:15911702 AGMAT 0.38 5.91 0.31 8.64e-9 Systolic blood pressure; LUSC cis rs4704187 0.687 rs115403098 chr5:74397384 A/G cg03227963 chr5:74354835 NA 0.32 6.89 0.35 2.74e-11 Response to amphetamines; LUSC cis rs2073300 0.609 rs6132605 chr20:23354839 A/C cg12062639 chr20:23401060 NAPB 0.97 7.93 0.4 3.23e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg21361702 chr7:150065534 REPIN1 0.48 6.79 0.35 5.1e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg26384229 chr12:38710491 ALG10B 0.92 15.65 0.65 8.39e-42 Bladder cancer; LUSC cis rs9399135 0.933 rs7755680 chr6:135294259 A/G cg22676075 chr6:135203613 NA 0.47 7.38 0.37 1.25e-12 Red blood cell count; LUSC cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg18132916 chr6:79620363 NA -0.37 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg18512352 chr11:47633146 NA -0.48 -9.73 -0.47 7.1e-20 Subjective well-being; LUSC cis rs6964587 0.626 rs34404183 chr7:91551249 T/C cg17063962 chr7:91808500 NA -0.56 -9.23 -0.45 3.27e-18 Breast cancer; LUSC cis rs4474465 0.607 rs4945303 chr11:78283803 A/G cg27205649 chr11:78285834 NARS2 0.59 7.31 0.37 2e-12 Alzheimer's disease (survival time); LUSC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg08270630 chr22:50330655 NA -0.48 -6.92 -0.35 2.34e-11 Schizophrenia; LUSC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs1670533 1.000 rs2014318 chr4:1068778 C/T cg02018176 chr4:1364513 KIAA1530 -0.44 -6.18 -0.32 1.89e-9 Recombination rate (females); LUSC cis rs9287719 0.967 rs10206225 chr2:10758657 A/G cg00105475 chr2:10696890 NA 0.36 6.08 0.32 3.35e-9 Prostate cancer; LUSC cis rs2439831 0.850 rs68079546 chr15:44136957 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.91 0.35 2.39e-11 Lung cancer in ever smokers; LUSC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg25427524 chr10:38739819 LOC399744 0.58 10.6 0.5 8.09e-23 Extrinsic epigenetic age acceleration; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg08888203 chr3:10149979 C3orf24 0.66 9.07 0.44 1.06e-17 Alzheimer's disease; LUSC cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg00530320 chr1:46809349 NSUN4 0.56 8.56 0.42 4.26e-16 Menopause (age at onset); LUSC cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg12011299 chr4:100065546 ADH4 -0.7 -10.92 -0.51 5.98e-24 Alcohol dependence; LUSC trans rs2243480 1.000 rs316317 chr7:65613637 G/T cg10756647 chr7:56101905 PSPH 0.88 8.91 0.44 3.39e-17 Diabetic kidney disease; LUSC cis rs721399 0.539 rs10089958 chr8:18269343 A/G cg18736775 chr8:18248649 NAT2 -0.57 -6.72 -0.34 8.06e-11 Blood metabolite levels; LUSC cis rs5753618 0.583 rs5753639 chr22:31870400 A/G cg02404636 chr22:31891804 SFI1 -0.39 -5.83 -0.3 1.29e-8 Colorectal cancer; LUSC trans rs62238980 0.614 rs75142210 chr22:32398992 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg02551604 chr5:131831745 NA 0.45 6.96 0.36 1.85e-11 Asthma (sex interaction); LUSC cis rs12760731 0.623 rs2862378 chr1:178296566 A/G cg00404053 chr1:178313656 RASAL2 0.47 5.81 0.3 1.48e-8 Obesity-related traits; LUSC cis rs7789940 1.000 rs2072435 chr7:75959188 G/A cg10167463 chr7:75959203 YWHAG -0.66 -10.1 -0.48 4.04e-21 Multiple sclerosis; LUSC cis rs708547 0.957 rs2458552 chr4:57773442 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.54 6.57 0.34 1.88e-10 Response to bleomycin (chromatid breaks); LUSC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg17724175 chr1:150552817 MCL1 0.35 6.38 0.33 5.96e-10 Tonsillectomy; LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg04944784 chr2:26401820 FAM59B 0.74 10.59 0.5 8.59e-23 Gut microbiome composition (summer); LUSC trans rs853679 0.517 rs3823180 chr6:28061744 G/A cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.31e-9 Depression; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.63 -0.34 1.32e-10 Bipolar disorder and schizophrenia; LUSC cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg26384229 chr12:38710491 ALG10B 0.94 17.96 0.7 5.88e-51 Heart rate; LUSC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg19418458 chr7:158789849 NA 0.65 10.86 0.51 1.02e-23 Facial morphology (factor 20); LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13732083 chr21:47605072 C21orf56 0.42 6.27 0.32 1.14e-9 Testicular germ cell tumor; LUSC cis rs6456156 0.565 rs7750209 chr6:167482895 T/G cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg06637938 chr14:75390232 RPS6KL1 -0.53 -8.51 -0.42 5.85e-16 Coronary artery disease; LUSC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg03948781 chr1:205179583 DSTYK 0.3 5.68 0.3 2.98e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6005807 0.719 rs60693420 chr22:29045930 T/C cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs9560113 0.573 rs61955236 chr13:112242861 G/A cg10483660 chr13:112241077 NA 0.37 6.4 0.33 5.12e-10 Menarche (age at onset); LUSC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg03676636 chr4:99064102 C4orf37 0.32 6.9 0.35 2.61e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg10117171 chr1:25599238 RHD -0.38 -5.79 -0.3 1.63e-8 Erythrocyte sedimentation rate; LUSC cis rs7615952 0.932 rs7630077 chr3:125649676 T/C cg05084668 chr3:125655381 ALG1L -0.79 -11.62 -0.54 1.88e-26 Blood pressure (smoking interaction); LUSC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg06481639 chr22:41940642 POLR3H 0.5 5.69 0.3 2.8e-8 Vitiligo; LUSC cis rs1595825 0.891 rs16824631 chr2:198708695 T/G cg00982548 chr2:198649783 BOLL -0.59 -7.43 -0.38 9.41e-13 Ulcerative colitis; LUSC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg09034736 chr1:150693464 HORMAD1 0.42 5.8 0.3 1.55e-8 Melanoma; LUSC cis rs6987853 0.761 rs2974322 chr8:42424724 T/C cg09913449 chr8:42400586 C8orf40 0.52 9.1 0.45 8.55e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs11971779 0.616 rs6949963 chr7:139054325 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.59e-29 Prudent dietary pattern; LUSC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg17340268 chr14:105411764 AHNAK2 -0.38 -6.07 -0.32 3.41e-9 Rheumatoid arthritis; LUSC cis rs847577 0.715 rs12665986 chr7:97719676 A/G cg21770322 chr7:97807741 LMTK2 -0.45 -7.21 -0.37 3.67e-12 Breast cancer; LUSC cis rs12286929 0.702 rs11215419 chr11:115081810 A/T cg04055981 chr11:115044050 NA 0.4 7.04 0.36 1.11e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg18904891 chr8:8559673 CLDN23 0.53 7.22 0.37 3.57e-12 Obesity-related traits; LUSC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg21918786 chr6:109611834 NA -0.42 -7.29 -0.37 2.33e-12 Reticulocyte fraction of red cells; LUSC cis rs11690935 0.959 rs10204502 chr2:172588866 C/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.42 -0.62 5.29e-37 Schizophrenia; LUSC cis rs6840360 1.000 rs1864300 chr4:152663326 T/C cg22705602 chr4:152727874 NA -0.28 -6.02 -0.31 4.68e-9 Intelligence (multi-trait analysis); LUSC cis rs62408225 0.962 rs905671 chr6:90983850 A/T cg06866423 chr6:90926672 BACH2 0.41 5.91 0.31 8.67e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1048238 0.506 rs598371 chr1:16212739 G/A cg22431228 chr1:16359049 CLCNKA 0.42 8.44 0.42 9.8e-16 Systolic blood pressure; LUSC cis rs12291225 0.535 rs12806025 chr11:14413817 G/A cg05501817 chr11:14380813 RRAS2 -0.47 -7.41 -0.38 1.05e-12 Sense of smell; LUSC cis rs7824557 0.602 rs35807737 chr8:11204411 C/G cg21775007 chr8:11205619 TDH 0.82 13.79 0.6 1.53e-34 Retinal vascular caliber; LUSC trans rs208520 0.633 rs7738469 chr6:66807446 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -17.27 -0.69 3.44e-48 Exhaled nitric oxide output; LUSC cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.61 -0.6 7.34e-34 Chronic sinus infection; LUSC cis rs7809950 0.773 rs9791733 chr7:107041730 T/C cg23024343 chr7:107201750 COG5 -0.7 -10.08 -0.48 4.82e-21 Coronary artery disease; LUSC cis rs7202877 0.656 rs4887812 chr16:75310052 G/A cg03315344 chr16:75512273 CHST6 0.49 7.0 0.36 1.41e-11 Type 2 diabetes;Type 1 diabetes; LUSC cis rs644799 0.603 rs1255180 chr11:95472134 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.58 8.86 0.44 4.85e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg17892150 chr10:133769511 PPP2R2D -0.65 -8.73 -0.43 1.22e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs713587 0.806 rs6737082 chr2:25138040 A/C cg15423357 chr2:25149977 NA 0.46 9.45 0.46 5.97e-19 Body mass index in non-asthmatics; LUSC cis rs11711311 0.869 rs12493635 chr3:113373019 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.29 0.33 9.66e-10 IgG glycosylation; LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.69 -0.57 2.24e-30 Platelet count; LUSC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg07701084 chr6:150067640 NUP43 0.56 8.51 0.42 6.09e-16 Lung cancer; LUSC cis rs34638657 0.872 rs8051436 chr16:82171979 G/C cg09439754 chr16:82129088 HSD17B2 -0.37 -6.04 -0.31 4.17e-9 Lung adenocarcinoma; LUSC trans rs5756813 0.754 rs3788529 chr22:38158709 A/G cg19894588 chr14:64061835 NA -0.57 -7.44 -0.38 8.61e-13 Optic cup area;Vertical cup-disc ratio; LUSC cis rs1580019 0.922 rs1466147 chr7:32486262 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.83 12.19 0.55 1.6e-28 Cognitive ability; LUSC cis rs4363385 0.747 rs1129655 chr1:152958267 T/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.5 -0.38 5.99e-13 Inflammatory skin disease; LUSC cis rs7584330 0.736 rs6431541 chr2:238376190 A/T cg16989719 chr2:238392110 NA -0.37 -6.6 -0.34 1.6e-10 Prostate cancer; LUSC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10751667 0.666 rs7944815 chr11:959776 C/T ch.11.42038R chr11:967971 AP2A2 0.44 6.6 0.34 1.63e-10 Alzheimer's disease (late onset); LUSC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg24531977 chr5:56204891 C5orf35 -0.61 -8.84 -0.44 5.54e-17 Coronary artery disease; LUSC cis rs76793172 0.920 rs77588767 chr19:46326472 G/C cg27118825 chr19:46318748 RSPH6A;SYMPK 0.46 5.69 0.3 2.75e-8 Eosinophil counts; LUSC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg12463550 chr7:65579703 CRCP -0.55 -8.09 -0.4 1.11e-14 Aortic root size; LUSC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -12.3 -0.56 5.96e-29 Hemoglobin concentration; LUSC cis rs7953249 0.656 rs1732391 chr12:121392341 C/T cg02403541 chr12:121454288 C12orf43 -0.72 -11.05 -0.52 2.08e-24 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs11098499 0.863 rs13140409 chr4:120503460 A/G cg24375607 chr4:120327624 NA 0.76 11.45 0.53 7.76e-26 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17907730 chr7:35077704 DPY19L1 -0.42 -6.22 -0.32 1.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2637266 0.777 rs2637253 chr10:78311287 A/C cg18941641 chr10:78392320 NA -0.36 -6.29 -0.33 9.77e-10 Pulmonary function; LUSC cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.45 -0.42 8.92e-16 Schizophrenia; LUSC trans rs4332037 0.539 rs55993248 chr7:2071132 A/G cg25206134 chr2:45395956 NA 0.59 6.91 0.35 2.4e-11 Bipolar disorder; LUSC cis rs7582180 0.764 rs11683121 chr2:100920705 C/T cg08017756 chr2:100939284 LONRF2 -0.44 -8.33 -0.41 2.05e-15 Intelligence (multi-trait analysis); LUSC trans rs9747201 1.000 rs4347682 chr17:80175591 A/G cg07393940 chr7:158741817 NA 0.51 8.0 0.4 2.07e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg03948781 chr1:205179583 DSTYK 0.29 5.65 0.3 3.53e-8 Mean corpuscular volume;Mean platelet volume; LUSC trans rs4729127 1.000 rs9641132 chr7:94011381 G/T cg14660007 chr13:78271894 SLAIN1 0.51 6.61 0.34 1.5e-10 Intelligence; LUSC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.61 -0.38 2.79e-13 Aortic root size; LUSC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg23719950 chr11:63933701 MACROD1 -0.62 -8.08 -0.4 1.22e-14 Mean platelet volume; LUSC trans rs9951602 1.000 rs1903723 chr18:76646571 A/G cg02800362 chr5:177631904 HNRNPAB 0.98 11.15 0.52 9.51e-25 Obesity-related traits; LUSC cis rs2219968 0.962 rs2368508 chr8:78951278 T/C cg00738934 chr8:78996279 NA 0.38 6.73 0.35 7.25e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs3540 0.574 rs2601205 chr15:90961813 A/G cg03599575 chr15:90893182 GABARAPL3 0.33 5.81 0.3 1.47e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.56 0.38 3.82e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07862889 chr17:21156915 C17orf103 0.44 6.6 0.34 1.61e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs17540621 0.744 rs116777406 chr2:47196252 A/C cg23978866 chr2:47230407 TTC7A -0.92 -6.91 -0.35 2.44e-11 Response to statin therapy; LUSC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg18876405 chr7:65276391 NA -0.54 -8.54 -0.42 4.87e-16 Aortic root size; LUSC cis rs2522056 0.935 rs1981524 chr5:131756506 C/T cg24060327 chr5:131705240 SLC22A5 0.48 6.32 0.33 8.29e-10 Lymphocyte counts;Fibrinogen; LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg07395648 chr5:131743802 NA -0.38 -5.76 -0.3 1.88e-8 Breast cancer; LUSC cis rs1891275 0.515 rs7093728 chr10:93443617 C/T cg07889827 chr10:93443413 NA -0.38 -8.55 -0.42 4.34e-16 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg13798780 chr7:105162888 PUS7 0.53 5.93 0.31 7.72e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg05132306 chr1:1846340 CALML6 -0.34 -8.61 -0.43 2.93e-16 Body mass index; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10292851 chr8:101572103 ANKRD46 -0.47 -6.02 -0.31 4.55e-9 Hepatitis; LUSC cis rs4664304 1.000 rs3806603 chr2:160761808 T/C cg03641300 chr2:160917029 PLA2R1 -0.42 -6.79 -0.35 5.22e-11 Crohn's disease;Inflammatory bowel disease; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg25555424 chr11:2950735 PHLDA2 0.41 6.17 0.32 1.98e-9 Schizophrenia (age at onset); LUSC cis rs7582180 0.627 rs2099611 chr2:101021090 A/G cg12002119 chr2:101014098 CHST10 0.36 6.16 0.32 2.1e-9 Intelligence (multi-trait analysis); LUSC cis rs12210905 0.858 rs72838249 chr6:26998489 A/G cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.95 -0.31 6.94e-9 Hip circumference adjusted for BMI; LUSC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg16325326 chr1:53192061 ZYG11B 0.94 17.26 0.69 3.71e-48 Monocyte count; LUSC cis rs17102423 0.723 rs8181939 chr14:65555758 G/A cg11161011 chr14:65562177 MAX -0.81 -12.51 -0.56 1.01e-29 Obesity-related traits; LUSC cis rs6665290 0.904 rs7541033 chr1:227188371 C/A cg10327440 chr1:227177885 CDC42BPA -1.21 -39.71 -0.91 1.49e-128 Myeloid white cell count; LUSC trans rs35110281 0.667 rs2155722 chr21:45096206 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.61 -10.46 -0.5 2.54e-22 Mean corpuscular volume; LUSC cis rs6500395 1.000 rs11644518 chr16:48616789 A/G cg04672837 chr16:48644449 N4BP1 0.5 7.48 0.38 6.46e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg10909506 chr17:38081995 ORMDL3 0.35 6.16 0.32 2.11e-9 Self-reported allergy; LUSC cis rs34734847 0.842 rs7308648 chr12:121144144 C/G cg21892295 chr12:121157589 UNC119B -0.37 -6.51 -0.34 2.8e-10 Mean corpuscular volume; LUSC cis rs9905704 0.647 rs33922512 chr17:57114148 C/G cg05425664 chr17:57184151 TRIM37 0.49 7.32 0.37 1.84e-12 Testicular germ cell tumor; LUSC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg06074448 chr4:187884817 NA -0.41 -6.89 -0.35 2.85e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2806561 0.578 rs6702719 chr1:23302576 T/C cg12483005 chr1:23474871 LUZP1 0.42 6.17 0.32 1.99e-9 Height; LUSC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg22800045 chr5:56110881 MAP3K1 0.76 10.05 0.48 6.05e-21 Initial pursuit acceleration; LUSC cis rs9815354 0.767 rs73071238 chr3:41992243 A/G cg03022575 chr3:42003672 ULK4 0.85 8.86 0.44 4.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs17270561 0.609 rs1408271 chr6:25859621 T/A cg17691542 chr6:26056736 HIST1H1C 0.49 6.89 0.35 2.86e-11 Iron status biomarkers; LUSC cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.94 0.7 7.29e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.31 -5.8 -0.3 1.55e-8 Lymphocyte counts; LUSC cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg05234568 chr11:5960015 NA -0.54 -7.58 -0.38 3.37e-13 DNA methylation (variation); LUSC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg21471580 chr8:22132874 PIWIL2 0.35 6.06 0.31 3.75e-9 Hypertriglyceridemia; LUSC trans rs7829975 0.714 rs12544992 chr8:8661681 C/G cg21775007 chr8:11205619 TDH 0.45 6.46 0.33 3.63e-10 Mood instability; LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg00814883 chr7:100076585 TSC22D4 -0.66 -8.53 -0.42 5.25e-16 Platelet count; LUSC cis rs10751667 0.666 rs7396677 chr11:958878 C/T ch.11.42038R chr11:967971 AP2A2 0.44 6.65 0.34 1.22e-10 Alzheimer's disease (late onset); LUSC cis rs11098499 0.754 rs1546503 chr4:120241167 T/C cg24375607 chr4:120327624 NA 0.75 11.72 0.54 8.65e-27 Corneal astigmatism; LUSC cis rs7481584 0.624 rs440130 chr11:3051476 A/G cg08508325 chr11:3079039 CARS 0.38 8.51 0.42 6.01e-16 Calcium levels; LUSC trans rs3857536 0.740 rs7773577 chr6:66892124 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg00569385 chr1:151032336 MLLT11;CDC42SE1 0.55 6.61 0.34 1.48e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg26677194 chr12:130822605 PIWIL1 0.59 8.77 0.43 9.52e-17 Menopause (age at onset); LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg14159672 chr1:205819179 PM20D1 -0.49 -7.51 -0.38 5.32e-13 Menarche (age at onset); LUSC cis rs597583 0.951 rs599411 chr11:117422262 T/G cg27161313 chr11:117392002 DSCAML1 -0.39 -7.0 -0.36 1.39e-11 Putamen volume; LUSC cis rs80282103 0.764 rs10047383 chr10:1103095 A/G cg18964960 chr10:1102726 WDR37 0.73 6.71 0.34 8.45e-11 Glomerular filtration rate (creatinine); LUSC cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg06462663 chr19:18546047 ISYNA1 0.47 8.05 0.4 1.49e-14 Breast cancer; LUSC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg13939156 chr17:80058883 NA -0.33 -6.44 -0.33 4.14e-10 Life satisfaction; LUSC cis rs62064224 0.589 rs8069673 chr17:30661250 C/T cg18200150 chr17:30822561 MYO1D -0.29 -5.72 -0.3 2.31e-8 Schizophrenia; LUSC cis rs9828933 0.752 rs13434089 chr3:63948566 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.64 6.3 0.33 9.21e-10 Type 2 diabetes; LUSC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg05729581 chr11:3078854 CARS -0.54 -8.25 -0.41 3.8e-15 Longevity; LUSC cis rs12681288 0.676 rs6559208 chr8:1018833 A/G cg04851639 chr8:1020857 NA -0.38 -7.77 -0.39 1e-13 Schizophrenia; LUSC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg15839431 chr19:19639596 YJEFN3 -0.5 -6.81 -0.35 4.59e-11 Tonsillectomy; LUSC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg02269571 chr22:50332266 NA -0.57 -8.45 -0.42 9.4e-16 Schizophrenia; LUSC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.04 -0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC trans rs7824557 0.767 rs11775635 chr8:11164865 G/A cg06636001 chr8:8085503 FLJ10661 0.52 7.87 0.4 5.14e-14 Retinal vascular caliber; LUSC cis rs4954585 0.683 rs4452212 chr2:137015991 G/A cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.79e-13 Colorectal cancer; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg00149659 chr3:10157352 C3orf10 1.01 14.42 0.62 5.3e-37 Alzheimer's disease; LUSC cis rs6542838 0.582 rs6542845 chr2:99537600 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.06 -0.31 3.77e-9 Fear of minor pain; LUSC cis rs17030434 0.906 rs11099901 chr4:154671468 T/A cg14289246 chr4:154710475 SFRP2 -0.49 -6.47 -0.33 3.43e-10 Electrocardiographic conduction measures; LUSC cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg07636037 chr3:49044803 WDR6 -0.73 -8.81 -0.43 7.03e-17 Menarche (age at onset); LUSC cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg01483505 chr11:975446 AP2A2 0.4 5.74 0.3 2.17e-8 Alzheimer's disease (late onset); LUSC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.58 -0.34 1.78e-10 Lung cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19641644 chr7:44365627 CAMK2B 0.4 6.08 0.32 3.29e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1499972 0.941 rs62264766 chr3:117641227 A/G cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.93e-8 Schizophrenia; LUSC cis rs73206853 0.563 rs881961 chr12:111201646 C/T cg12870014 chr12:110450643 ANKRD13A 0.64 6.42 0.33 4.55e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7647973 0.769 rs6446204 chr3:49034879 T/C cg07636037 chr3:49044803 WDR6 0.91 11.6 0.54 2.31e-26 Menarche (age at onset); LUSC cis rs4242434 0.927 rs7843616 chr8:22466541 T/C cg03733263 chr8:22462867 KIAA1967 0.99 18.13 0.7 1.23e-51 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs11122272 0.735 rs2808586 chr1:231515559 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg26597838 chr10:835615 NA 0.8 11.39 0.53 1.29e-25 Eosinophil percentage of granulocytes; LUSC cis rs9303401 0.527 rs12946522 chr17:56768103 A/C cg25039879 chr17:56429692 SUPT4H1 0.58 7.54 0.38 4.53e-13 Cognitive test performance; LUSC trans rs7829975 0.714 rs12544992 chr8:8661681 C/G cg27411982 chr8:10470053 RP1L1 0.41 6.43 0.33 4.53e-10 Mood instability; LUSC cis rs9473147 0.516 rs7754282 chr6:47502024 C/G cg12968598 chr6:47444699 CD2AP -0.52 -7.86 -0.4 5.26e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg12935359 chr14:103987150 CKB 0.65 10.45 0.5 2.68e-22 Intelligence (multi-trait analysis); LUSC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg10053473 chr17:62856997 LRRC37A3 -0.67 -10.5 -0.5 1.8e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1865760 0.865 rs9467650 chr6:25958235 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.9 0.35 2.67e-11 Height; LUSC cis rs10979 1.000 rs6570566 chr6:143899534 G/A cg25407410 chr6:143891975 LOC285740 -0.68 -10.53 -0.5 1.42e-22 Hypospadias; LUSC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg24977027 chr2:88469347 THNSL2 0.56 5.93 0.31 7.76e-9 Plasma clusterin levels; LUSC cis rs7937682 0.924 rs10891286 chr11:111532691 C/G cg09085632 chr11:111637200 PPP2R1B -1.11 -18.45 -0.71 6.86e-53 Primary sclerosing cholangitis; LUSC cis rs9814567 1.000 rs3932818 chr3:134206069 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.59 -0.6 8.31e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg15383120 chr6:291909 DUSP22 -0.65 -10.98 -0.51 3.88e-24 Menopause (age at onset); LUSC cis rs394563 0.967 rs420099 chr6:149794290 A/C cg03678062 chr6:149772716 ZC3H12D -0.3 -6.15 -0.32 2.24e-9 Dupuytren's disease; LUSC trans rs6502050 0.799 rs28376857 chr17:80104351 G/A cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs295140 0.837 rs12474914 chr2:201130210 A/G cg04283868 chr2:201171347 SPATS2L 0.41 5.95 0.31 6.78e-9 QT interval; LUSC cis rs394563 0.591 rs237035 chr6:149710848 C/T cg11245181 chr6:149772854 ZC3H12D -0.3 -6.41 -0.33 5.09e-10 Dupuytren's disease; LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg11843238 chr5:131593191 PDLIM4 0.4 6.72 0.35 7.67e-11 Breast cancer; LUSC cis rs2346177 0.580 rs1530628 chr2:46670941 A/G cg02822958 chr2:46747628 ATP6V1E2 0.44 7.67 0.39 1.88e-13 HDL cholesterol; LUSC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg10896456 chr17:42255109 ASB16;C17orf65 0.49 8.11 0.41 1.01e-14 Total body bone mineral density; LUSC cis rs9875589 0.509 rs6442423 chr3:14016062 G/A cg19554555 chr3:13937349 NA -0.38 -5.75 -0.3 2e-8 Ovarian reserve; LUSC cis rs616402 0.527 rs10779737 chr1:10580275 C/G cg17425144 chr1:10567563 PEX14 0.65 13.45 0.59 2.93e-33 Breast size; LUSC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg21453287 chr8:37963019 ASH2L 0.47 6.74 0.35 7.08e-11 Risky sexual behaviors in alcohol dependence; LUSC cis rs6582630 0.519 rs11495373 chr12:38275470 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.65 0.5 5.27e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg13010199 chr12:38710504 ALG10B 0.7 11.5 0.53 5.12e-26 Heart rate; LUSC cis rs1577917 0.883 rs9450375 chr6:86756629 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 6.22 0.32 1.51e-9 Response to antipsychotic treatment; LUSC cis rs7267979 1.000 rs6050544 chr20:25320228 T/A cg08601574 chr20:25228251 PYGB -0.44 -6.74 -0.35 6.84e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.16 16.01 0.66 3.2e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg07685180 chr8:600429 NA 0.57 5.89 0.31 9.32e-9 IgG glycosylation; LUSC cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg07828340 chr4:882639 GAK 1.03 10.95 0.51 4.79e-24 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.545 rs7980848 chr12:39375166 G/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs80282103 0.618 rs7100114 chr10:1110231 A/G cg08668510 chr10:1095578 IDI1 0.74 6.11 0.32 2.77e-9 Glomerular filtration rate (creatinine); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13411583 chr12:122064640 ORAI1 -0.44 -6.84 -0.35 3.84e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6700896 0.500 rs11208687 chr1:66076358 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg22166914 chr1:53195759 ZYG11B -0.61 -10.23 -0.49 1.57e-21 Monocyte count; LUSC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg11663144 chr21:46675770 NA 0.44 7.9 0.4 4.2e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -12.36 -0.56 3.62e-29 Platelet count; LUSC cis rs2692947 0.666 rs10183151 chr2:96774786 T/G cg22654517 chr2:96458247 NA -0.32 -5.82 -0.3 1.39e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4820539 1.000 rs2267002 chr22:23456702 T/C cg14186256 chr22:23484241 RTDR1 0.95 17.72 0.7 5.54e-50 Bone mineral density; LUSC trans rs11098499 0.505 rs75122014 chr4:120362426 G/C cg25214090 chr10:38739885 LOC399744 0.56 8.21 0.41 4.83e-15 Corneal astigmatism; LUSC cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg25258033 chr6:167368657 RNASET2 0.39 6.3 0.33 9.49e-10 Crohn's disease; LUSC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg17971929 chr21:40555470 PSMG1 0.79 13.91 0.61 4.96e-35 Cognitive function; LUSC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg02269571 chr22:50332266 NA -0.59 -8.72 -0.43 1.37e-16 Schizophrenia; LUSC trans rs1994135 0.654 rs11052759 chr12:33724126 G/A cg13010199 chr12:38710504 ALG10B 0.55 7.56 0.38 3.86e-13 Resting heart rate; LUSC cis rs6961069 0.671 rs10268340 chr7:80224798 T/G cg04458919 chr7:80252533 CD36 -0.41 -7.25 -0.37 2.98e-12 Platelet count; LUSC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.5 -9.68 -0.47 1.05e-19 Monocyte percentage of white cells; LUSC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg08244238 chr11:790193 CEND1 0.33 5.67 0.3 3.03e-8 Breast cancer; LUSC cis rs7771547 0.519 rs6923337 chr6:36369260 C/T cg07856975 chr6:36356162 ETV7 0.45 6.63 0.34 1.35e-10 Platelet distribution width; LUSC cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg05283184 chr6:79620031 NA -0.57 -12.13 -0.55 2.55e-28 Intelligence (multi-trait analysis); LUSC cis rs7100689 0.577 rs4934038 chr10:82057334 C/A cg01528321 chr10:82214614 TSPAN14 0.9 13.42 0.59 3.9e-33 Post bronchodilator FEV1; LUSC cis rs7296418 0.699 rs11608297 chr12:123826642 T/C cg05973401 chr12:123451056 ABCB9 0.55 8.05 0.4 1.5e-14 Platelet count; LUSC cis rs11098499 0.789 rs10212719 chr4:120254437 T/C cg24375607 chr4:120327624 NA 0.77 12.56 0.57 6.5e-30 Corneal astigmatism; LUSC cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.14 0.55 2.36e-28 Colorectal cancer; LUSC cis rs7107174 1.000 rs10899489 chr11:78095373 G/T cg02023728 chr11:77925099 USP35 0.46 6.74 0.35 7.17e-11 Testicular germ cell tumor; LUSC trans rs4843747 0.518 rs4072777 chr16:88107030 G/A cg26811252 chr16:29126840 RRN3P2 0.58 9.21 0.45 3.72e-18 Menopause (age at onset); LUSC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg13393036 chr8:95962371 TP53INP1 -0.47 -9.69 -0.47 9.8e-20 Type 2 diabetes; LUSC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.19 -0.45 4.25e-18 Monocyte percentage of white cells; LUSC trans rs12439619 0.846 rs62012003 chr15:82475577 T/A cg04831495 chr15:85060580 GOLGA6L5 -0.47 -6.38 -0.33 5.95e-10 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.967 rs7313443 chr12:86332940 G/A cg02569458 chr12:86230093 RASSF9 0.42 6.86 0.35 3.31e-11 Major depressive disorder; LUSC cis rs11630290 1.000 rs72750986 chr15:63996338 C/A cg12036633 chr15:63758958 NA -0.73 -8.09 -0.4 1.12e-14 Iris characteristics; LUSC cis rs1371867 0.641 rs1788209 chr8:101337056 C/T cg00191853 chr8:101177733 SPAG1 -0.37 -6.2 -0.32 1.69e-9 Atrioventricular conduction; LUSC cis rs847577 0.550 rs12670686 chr7:97708397 A/G cg24562669 chr7:97807699 LMTK2 0.44 7.88 0.4 4.65e-14 Breast cancer; LUSC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg08847533 chr14:75593920 NEK9 -0.82 -14.83 -0.63 1.42e-38 Height; LUSC cis rs3733631 1.000 rs10010631 chr4:104644543 A/G cg24090629 chr4:104641072 TACR3 -0.48 -5.94 -0.31 7.32e-9 Menarche (age at onset); LUSC cis rs3812762 0.871 rs3862352 chr11:8818020 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.38 -6.36 -0.33 6.53e-10 Hypospadias; LUSC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs17632159 0.619 rs7379816 chr5:72428831 A/G cg01170694 chr5:72431891 NA -0.3 -6.16 -0.32 2.06e-9 Urate levels; LUSC trans rs2739330 0.828 rs5760107 chr22:24252597 T/C cg06437703 chr8:37914619 EIF4EBP1 -0.55 -8.5 -0.42 6.19e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2282032 1.000 rs115667214 chr14:90733890 A/G cg14092571 chr14:90743983 NA 0.56 7.04 0.36 1.11e-11 Longevity; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.82 0.78 4.1e-70 Prudent dietary pattern; LUSC cis rs7215564 0.908 rs4969411 chr17:78747982 T/C cg23238734 chr17:78661607 RPTOR -0.45 -5.71 -0.3 2.48e-8 Myopia (pathological); LUSC cis rs11122272 0.735 rs2790877 chr1:231535427 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.03 0.48 7.06e-21 Hemoglobin concentration; LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg07677032 chr17:61819896 STRADA 0.54 9.08 0.44 9.89e-18 Prudent dietary pattern; LUSC cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg23158103 chr7:148848205 ZNF398 -0.48 -7.73 -0.39 1.32e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9581857 0.685 rs9319369 chr13:28042323 A/T cg22138327 chr13:27999177 GTF3A 0.72 7.8 0.39 7.89e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs11971779 0.625 rs2355784 chr7:139072493 G/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs12594515 1.000 rs8029209 chr15:45993489 A/G cg19682013 chr15:45996608 NA 0.38 5.68 0.3 2.89e-8 Waist circumference;Weight; LUSC cis rs34779708 0.966 rs10827487 chr10:35406878 T/A cg03585969 chr10:35415529 CREM 0.62 9.13 0.45 6.91e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2408955 0.541 rs11168428 chr12:48547128 A/G cg24011408 chr12:48396354 COL2A1 -0.38 -5.66 -0.3 3.24e-8 Glycated hemoglobin levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16169373 chr8:67976534 CSPP1 -0.45 -6.79 -0.35 4.99e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4363385 0.818 rs10888524 chr1:153000125 A/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.11 -0.36 7.29e-12 Inflammatory skin disease; LUSC cis rs250677 1.000 rs250677 chr5:148433549 T/C cg18129178 chr5:148520854 ABLIM3 -0.68 -10.92 -0.51 6.06e-24 Breast cancer; LUSC cis rs4664304 0.595 rs2667004 chr2:160862094 G/A cg03641300 chr2:160917029 PLA2R1 -0.37 -6.03 -0.31 4.42e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg14440974 chr22:39074834 NA -0.37 -5.98 -0.31 5.75e-9 Menopause (age at onset); LUSC cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.53e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs17270561 0.887 rs717551 chr6:25855624 T/C cg17042849 chr6:26104293 HIST1H4C -0.5 -5.87 -0.31 1.06e-8 Iron status biomarkers; LUSC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg10802521 chr3:52805072 NEK4 -0.51 -8.52 -0.42 5.37e-16 Bipolar disorder; LUSC cis rs3736594 0.513 rs59876138 chr2:27792323 A/C cg27432699 chr2:27873401 GPN1 0.66 8.89 0.44 3.99e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg08917208 chr2:24149416 ATAD2B 1.01 10.6 0.5 8.3300000000000006e-23 Lymphocyte counts; LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.97 -21.38 -0.76 1.61e-64 Prudent dietary pattern; LUSC cis rs4845570 0.831 rs11588634 chr1:151780686 T/A cg07092448 chr1:151763213 TDRKH -1.18 -12.3 -0.56 6.06e-29 Coronary artery disease; LUSC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg12311346 chr5:56204834 C5orf35 -0.57 -8.78 -0.43 8.57e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs2742234 0.541 rs871763 chr10:43734188 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 7.05 0.36 1.03e-11 Hirschsprung disease; LUSC cis rs2651899 0.902 rs2742673 chr1:3080019 A/C cg22674798 chr1:3096360 PRDM16 -0.31 -7.03 -0.36 1.18e-11 Migraine; LUSC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.75 -9.51 -0.46 3.93e-19 Gut microbiome composition (summer); LUSC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.69 10.07 0.48 5.12e-21 IgG glycosylation; LUSC cis rs2708377 0.656 rs73066852 chr12:11276541 A/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.81 7.9 0.4 4.08e-14 Bitter taste perception; LUSC cis rs4466137 1.000 rs1154888 chr5:82977410 C/A cg16102102 chr5:83017553 HAPLN1 -0.91 -14.34 -0.62 1.12e-36 Prostate cancer; LUSC cis rs1775715 0.966 rs1755067 chr10:32296195 C/T cg04359828 chr10:32216031 ARHGAP12 -0.36 -6.09 -0.32 3.14e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7572644 0.679 rs4447576 chr2:28076248 T/C cg27432699 chr2:27873401 GPN1 0.51 6.96 0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg19230755 chr7:65878503 NA 0.43 6.1 0.32 3.01e-9 Aortic root size; LUSC trans rs853679 0.517 rs9368558 chr6:28133306 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20504077 chr8:27472321 CLU 0.8 6.31 0.33 9e-10 Cognitive performance; LUSC cis rs939658 0.683 rs1434459 chr15:79465210 T/C cg17916960 chr15:79447300 NA -0.43 -7.98 -0.4 2.39e-14 Refractive error; LUSC cis rs735396 1.000 rs2259852 chr12:121434833 G/A cg02403541 chr12:121454288 C12orf43 0.61 8.7 0.43 1.53e-16 N-glycan levels; LUSC trans rs8072100 0.967 rs4289035 chr17:45707211 C/T cg03886242 chr7:26192032 NFE2L3 -0.38 -6.28 -0.32 1.04e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs17095355 1.000 rs12570607 chr10:111696704 C/A cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.06 -0.36 9.89e-12 Biliary atresia; LUSC cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg12573674 chr2:1569213 NA 0.56 6.19 0.32 1.81e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.31 6.05 0.31 3.86e-9 Lymphocyte counts; LUSC cis rs716595 0.867 rs3793885 chr10:111988578 T/G cg13996003 chr10:112034540 MXI1 -0.7 -5.81 -0.3 1.42e-8 Normalized brain volume; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg13397359 chr6:42928475 GNMT 0.57 9.53 0.46 3.32e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1728785 1.000 rs698719 chr16:68560125 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.89 -0.31 9.61e-9 Ulcerative colitis; LUSC cis rs4689388 0.926 rs12508672 chr4:6287965 G/A cg25554036 chr4:6271136 WFS1 0.59 11.89 0.55 1.97e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7927592 0.913 rs7925275 chr11:68290433 T/C cg16797656 chr11:68205561 LRP5 0.38 6.22 0.32 1.48e-9 Total body bone mineral density; LUSC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg08859206 chr1:53392774 SCP2 -0.55 -9.55 -0.46 2.86e-19 Monocyte count; LUSC trans rs61931739 0.517 rs11052964 chr12:34010996 G/C cg13010199 chr12:38710504 ALG10B 0.56 8.32 0.41 2.26e-15 Morning vs. evening chronotype; LUSC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg14500267 chr11:67383377 NA 0.35 6.61 0.34 1.54e-10 Mean corpuscular volume; LUSC cis rs713477 1.000 rs2185036 chr14:55907710 A/G cg13175173 chr14:55914753 NA -0.32 -6.67 -0.34 1.07e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg13560548 chr3:10150139 C3orf24 0.53 7.37 0.37 1.39e-12 Alzheimer's disease; LUSC cis rs6740322 0.793 rs13414908 chr2:43546658 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.54 -7.51 -0.38 5.33e-13 Coronary artery disease; LUSC trans rs17780086 0.527 rs72827711 chr17:30537920 T/A cg20587970 chr11:113659929 NA -1.18 -11.79 -0.54 4.77e-27 Height; LUSC cis rs9473147 0.516 rs9395283 chr6:47551444 T/C cg12968598 chr6:47444699 CD2AP 0.52 8.04 0.4 1.6e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs8060686 0.641 rs12599880 chr16:68152035 A/G cg05110241 chr16:68378359 PRMT7 -0.58 -6.62 -0.34 1.41e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs13631 0.965 rs7853589 chr9:140003844 A/G cg03717367 chr9:139980219 LOC100289341;MAN1B1 -0.54 -9.73 -0.47 7.17e-20 Cerebrospinal fluid biomarker levels; LUSC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg02807482 chr3:125708958 NA -0.49 -6.65 -0.34 1.18e-10 Blood pressure (smoking interaction); LUSC cis rs11971779 0.553 rs10085770 chr7:139100349 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.25 -0.37 2.97e-12 Menopause (age at onset); LUSC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg13866156 chr1:1669148 SLC35E2 -0.51 -8.31 -0.41 2.4e-15 Body mass index; LUSC cis rs4969178 0.965 rs938350 chr17:76399552 C/T cg20026190 chr17:76395443 PGS1 0.42 7.64 0.39 2.35e-13 HDL cholesterol levels; LUSC cis rs2408955 0.504 rs11168441 chr12:48576054 G/A cg21466736 chr12:48725269 NA -0.31 -5.71 -0.3 2.52e-8 Glycated hemoglobin levels; LUSC cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg06784218 chr1:46089804 CCDC17 0.54 10.7 0.51 3.57e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7772486 0.902 rs2144476 chr6:146322484 G/A cg23711669 chr6:146136114 FBXO30 0.77 13.3 0.59 1.09e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs1991651 0.507 rs17778581 chr8:10743421 C/T cg15556689 chr8:8085844 FLJ10661 -0.54 -7.6 -0.38 2.96e-13 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; LUSC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg13319975 chr6:146136371 FBXO30 0.53 8.01 0.4 1.87e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2200578 0.786 rs62154639 chr2:99646954 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.56 6.53 0.34 2.42e-10 IgG glycosylation; LUSC cis rs9811920 0.695 rs1287284 chr3:99516962 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -7.29 -0.37 2.28e-12 Axial length; LUSC cis rs709400 0.633 rs7160208 chr14:103965528 G/A cg12935359 chr14:103987150 CKB -0.52 -8.0 -0.4 2.04e-14 Body mass index; LUSC cis rs4948275 0.550 rs10994742 chr10:63132240 A/T cg02461363 chr10:63212496 TMEM26 -0.37 -6.0 -0.31 5.27e-9 Night sleep phenotypes; LUSC cis rs1775715 0.870 rs1251407 chr10:32238325 A/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.64 0.34 1.26e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs59918340 0.764 rs4961338 chr8:142230192 C/T cg18755752 chr8:142205143 DENND3 0.38 5.67 0.3 3.11e-8 Immature fraction of reticulocytes; LUSC cis rs61931739 0.500 rs12146843 chr12:34451738 T/G cg06521331 chr12:34319734 NA -0.41 -6.74 -0.35 6.92e-11 Morning vs. evening chronotype; LUSC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg09877947 chr5:131593287 PDLIM4 0.47 7.72 0.39 1.39e-13 Breast cancer; LUSC cis rs1348850 0.539 rs1453371 chr2:178227862 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.43 5.86 0.31 1.09e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg13246856 chr1:44399776 ARTN 0.32 6.9 0.35 2.68e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs3755132 0.929 rs6431721 chr2:15791937 C/T cg12888861 chr2:15731646 DDX1 0.49 7.12 0.36 6.47e-12 Wilms tumor; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07853084 chr13:73632891 KLF5 -0.46 -5.97 -0.31 6.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs1962073 0.623 rs7459532 chr8:10261068 C/T cg21775007 chr8:11205619 TDH -0.49 -6.82 -0.35 4.16e-11 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); LUSC cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg23277830 chr1:3704460 LRRC47 0.35 6.55 0.34 2.14e-10 Red cell distribution width; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg13560548 chr3:10150139 C3orf24 0.49 6.85 0.35 3.53e-11 Alzheimer's disease; LUSC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.5 -0.34 2.94e-10 Alzheimer's disease (late onset); LUSC trans rs17685 0.753 rs1806885 chr7:75785612 T/G cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs870825 0.929 rs72689269 chr4:185592085 T/C cg04058563 chr4:185651563 MLF1IP 0.84 11.74 0.54 6.98e-27 Blood protein levels; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg03352830 chr11:487213 PTDSS2 0.69 8.64 0.43 2.43e-16 Body mass index; LUSC cis rs71403859 0.614 rs12149533 chr16:71801946 C/T cg08717414 chr16:71523259 ZNF19 -0.66 -6.96 -0.36 1.77e-11 Post bronchodilator FEV1; LUSC trans rs75804782 0.641 rs72983834 chr2:239319895 G/A cg01134436 chr17:81009848 B3GNTL1 0.64 6.08 0.32 3.37e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs950027 0.620 rs1426932 chr15:45687256 T/C cg14582100 chr15:45693742 SPATA5L1 0.45 8.5 0.42 6.48e-16 Response to fenofibrate (adiponectin levels); LUSC trans rs7980799 0.653 rs11052722 chr12:33626530 G/A cg26384229 chr12:38710491 ALG10B -0.54 -8.0 -0.4 2.11e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg05025164 chr4:1340916 KIAA1530 0.41 6.41 0.33 5.01e-10 Obesity-related traits; LUSC cis rs7428496 0.510 rs12638158 chr3:142306165 A/G cg16271453 chr3:142027066 XRN1 -0.48 -8.1 -0.41 1.07e-14 Mean corpuscular hemoglobin; LUSC cis rs4930103 0.711 rs217710 chr11:2007244 C/T cg06197492 chr11:2016605 H19 0.42 6.83 0.35 4.03e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs3105593 0.635 rs3131567 chr15:50757930 A/T cg08437265 chr15:50716283 USP8 0.38 5.73 0.3 2.3e-8 QT interval; LUSC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg05754148 chr16:3507555 NAT15 -0.55 -7.92 -0.4 3.63e-14 Tuberculosis; LUSC cis rs9311171 0.689 rs6790217 chr3:37949176 G/T cg12605080 chr3:37966887 CTDSPL -0.35 -6.81 -0.35 4.62e-11 Prostate cancer; LUSC cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.82 0.43 6.31e-17 Menopause (age at onset); LUSC trans rs6600671 1.000 rs10903161 chr1:121178741 A/T cg00646200 chr1:148855367 NA 0.47 7.54 0.38 4.61e-13 Hip geometry; LUSC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg05368731 chr17:41323189 NBR1 0.93 15.69 0.65 5.75e-42 Menopause (age at onset); LUSC cis rs7202877 0.610 rs3844219 chr16:75370230 G/T cg04384234 chr16:75411784 CFDP1 -0.64 -8.94 -0.44 2.73e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs4356932 1.000 rs13130018 chr4:76955519 G/A cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs7681440 0.647 rs1442133 chr4:90819195 C/T cg01966878 chr4:90757139 SNCA -0.35 -5.67 -0.3 3.04e-8 Dementia with Lewy bodies; LUSC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs853679 0.546 rs175597 chr6:27810626 T/C cg01620082 chr3:125678407 NA -0.75 -7.45 -0.38 8.11e-13 Depression; LUSC cis rs7903847 0.642 rs7918948 chr10:99124975 G/A cg20016023 chr10:99160130 RRP12 -0.28 -6.18 -0.32 1.85e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg11752832 chr7:134001865 SLC35B4 0.56 8.65 0.43 2.2e-16 Mean platelet volume; LUSC trans rs11250098 0.642 rs4841460 chr8:10789493 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.09 -0.36 7.93e-12 Morning vs. evening chronotype; LUSC cis rs701145 0.585 rs1727948 chr3:153876929 G/T cg17054900 chr3:154042577 DHX36 0.72 7.32 0.37 1.9e-12 Coronary artery disease; LUSC trans rs17685 0.725 rs7807647 chr7:75628669 G/A cg19862616 chr7:65841803 NCRNA00174 -1.12 -19.37 -0.73 1.41e-56 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs11122272 0.735 rs2246645 chr1:231497393 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.79 -0.47 4.53e-20 Hemoglobin concentration; LUSC trans rs11148252 0.595 rs9526974 chr13:53251040 C/G cg18335740 chr13:41363409 SLC25A15 0.76 13.66 0.6 4.82e-34 Lewy body disease; LUSC cis rs6489882 0.867 rs4766672 chr12:113365148 A/G cg20102336 chr12:113376681 OAS3 -0.42 -6.05 -0.31 3.78e-9 Chronic lymphocytic leukemia; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg08742575 chr21:47604166 C21orf56 0.43 6.4 0.33 5.33e-10 Testicular germ cell tumor; LUSC cis rs61931739 0.517 rs1843738 chr12:34056935 C/T cg06521331 chr12:34319734 NA -0.47 -7.63 -0.39 2.42e-13 Morning vs. evening chronotype; LUSC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg11301795 chr4:187892539 NA -0.81 -15.8 -0.65 2.26e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg18904891 chr8:8559673 CLDN23 -0.37 -5.9 -0.31 8.68e-9 Mood instability; LUSC trans rs1499614 1.000 rs2141924 chr7:66186246 C/T cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 7.85 0.39 5.61e-14 Prudent dietary pattern; LUSC cis rs11997175 0.580 rs34398087 chr8:33813800 A/G ch.8.33884649F chr8:33765107 NA -0.41 -6.14 -0.32 2.4e-9 Body mass index; LUSC cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg08975724 chr8:8085496 FLJ10661 0.43 5.85 0.3 1.16e-8 Neuroticism; LUSC cis rs17095355 1.000 rs752584 chr10:111682934 C/G cg00817464 chr10:111662876 XPNPEP1 -0.64 -7.24 -0.37 3.03e-12 Biliary atresia; LUSC cis rs11122272 0.735 rs2790892 chr1:231512771 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs2463822 0.920 rs28678254 chr11:62151875 G/C cg06239285 chr11:62104954 ASRGL1 -0.93 -10.31 -0.49 7.79e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs71403859 0.803 rs7203606 chr16:71590511 A/C cg08717414 chr16:71523259 ZNF19 -0.74 -8.19 -0.41 5.46e-15 Post bronchodilator FEV1; LUSC cis rs7789940 0.809 rs12533836 chr7:75935622 G/T cg10167463 chr7:75959203 YWHAG -0.61 -8.96 -0.44 2.4e-17 Multiple sclerosis; LUSC cis rs939658 0.626 rs11631406 chr15:79445789 C/T cg17916960 chr15:79447300 NA -0.46 -9.06 -0.44 1.11e-17 Refractive error; LUSC cis rs9790314 1.000 rs6794601 chr3:160946769 C/T cg03342759 chr3:160939853 NMD3 -0.51 -8.49 -0.42 6.66e-16 Morning vs. evening chronotype; LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 14.99 0.63 3.42e-39 Platelet count; LUSC trans rs9747201 0.862 rs11651738 chr17:80178691 A/T cg07393940 chr7:158741817 NA 0.53 8.22 0.41 4.42e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs2797160 1.000 rs1418948 chr6:126007018 C/T cg05039488 chr6:79577232 IRAK1BP1 0.46 6.74 0.35 6.9e-11 Endometrial cancer; LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg10802521 chr3:52805072 NEK4 -0.57 -8.94 -0.44 2.78e-17 Bipolar disorder; LUSC cis rs3820068 0.608 rs12091750 chr1:16042766 T/C cg13390004 chr1:15929781 NA 0.42 6.82 0.35 4.38e-11 Systolic blood pressure; LUSC cis rs2073300 1.000 rs6137957 chr20:23437384 G/A cg09953122 chr20:23471693 CST8 -0.9 -7.18 -0.37 4.55e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg02503808 chr4:7069936 GRPEL1 1.05 14.94 0.63 5.16e-39 Monocyte percentage of white cells; LUSC cis rs4631830 0.863 rs4554834 chr10:51530146 A/C cg20129853 chr10:51489980 NA -0.34 -6.86 -0.35 3.36e-11 Prostate-specific antigen levels; LUSC cis rs548181 0.545 rs1054997 chr11:125618813 G/A cg03464685 chr11:125439445 EI24 -0.93 -10.96 -0.51 4.55e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs61931739 0.500 rs12832312 chr12:34031199 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.31 0.53 2.59e-25 Morning vs. evening chronotype; LUSC cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg03453431 chr7:157225567 NA -0.58 -10.43 -0.5 3e-22 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs7582180 0.817 rs1437967 chr2:100929072 C/G cg08017756 chr2:100939284 LONRF2 -0.44 -8.36 -0.42 1.7e-15 Intelligence (multi-trait analysis); LUSC cis rs1865760 0.865 rs9467641 chr6:25947236 T/C cg16482183 chr6:26056742 HIST1H1C 0.47 6.92 0.35 2.38e-11 Height; LUSC cis rs9902453 0.817 rs2617880 chr17:28106118 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -9.32 -0.45 1.67e-18 Coffee consumption (cups per day); LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg16145915 chr7:1198662 ZFAND2A -0.64 -12.45 -0.56 1.76e-29 Longevity;Endometriosis; LUSC cis rs1005224 0.927 rs8007792 chr14:76175666 C/A cg04684003 chr14:76127793 TTLL5;C14orf1 -0.59 -8.1 -0.41 1.07e-14 Large artery stroke; LUSC cis rs1712517 0.744 rs11191641 chr10:105052940 C/T cg05636881 chr10:105038444 INA 0.39 6.32 0.33 8.31e-10 Migraine; LUSC cis rs9814567 0.752 rs6779326 chr3:134330027 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1007190 0.881 rs9900293 chr17:42936003 G/C cg15406952 chr17:42872593 NA 0.56 5.69 0.3 2.75e-8 DNA methylation (variation); LUSC cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg11584989 chr19:19387371 SF4 0.61 7.17 0.37 5e-12 Bipolar disorder; LUSC cis rs4654899 0.785 rs12070677 chr1:21337322 A/G cg01072550 chr1:21505969 NA -0.53 -8.16 -0.41 7.06e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.84 0.39 6.27e-14 Bipolar disorder; LUSC cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg22508957 chr16:3507546 NAT15 -0.39 -6.05 -0.31 3.95e-9 Body mass index (adult); LUSC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg13531842 chr10:38383804 ZNF37A -0.44 -6.84 -0.35 3.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14442939 chr10:27389572 ANKRD26 0.91 9.5 0.46 4.2e-19 Breast cancer; LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs4356932 1.000 rs4359937 chr4:76972155 G/A cg00809888 chr4:76862425 NAAA 0.36 5.98 0.31 5.81e-9 Blood protein levels; LUSC cis rs10911232 0.507 rs7547953 chr1:183031641 T/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.01 0.52 2.93e-24 Hypertriglyceridemia; LUSC cis rs8067287 0.762 rs11649835 chr17:16823541 C/G cg26910001 chr17:16838321 NA -0.48 -6.27 -0.32 1.11e-9 Diabetic kidney disease; LUSC cis rs7923609 0.841 rs2163188 chr10:65314711 G/C cg01631684 chr10:65280961 REEP3 0.41 6.05 0.31 3.84e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs4290604 0.596 rs7566199 chr2:238053391 A/G cg23555395 chr2:238036564 NA -0.52 -6.94 -0.35 2.07e-11 Asthma; LUSC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg25767906 chr1:53392781 SCP2 0.44 7.76 0.39 1.08e-13 Monocyte count; LUSC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg04727924 chr7:799746 HEATR2 -0.55 -6.7 -0.34 8.94e-11 Cerebrospinal P-tau181p levels; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.81 10.54 0.5 1.31e-22 Alzheimer's disease; LUSC cis rs1559088 0.948 rs12460195 chr19:33584479 G/A cg17764715 chr19:33622953 WDR88 0.6 8.29 0.41 2.72e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.36 0.37 1.42e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs7647973 0.626 rs62262722 chr3:49769419 G/C cg21659725 chr3:3221576 CRBN 0.69 8.05 0.4 1.42e-14 Menarche (age at onset); LUSC cis rs34421088 0.506 rs2409755 chr8:11169983 G/A cg21775007 chr8:11205619 TDH 0.47 6.93 0.35 2.22e-11 Neuroticism; LUSC cis rs7246657 0.943 rs1035479 chr19:37893300 G/T cg23950597 chr19:37808831 NA 0.63 7.73 0.39 1.27e-13 Coronary artery calcification; LUSC cis rs7592578 0.679 rs59929070 chr2:191327852 A/G cg10560079 chr2:191398806 TMEM194B -0.66 -8.08 -0.4 1.18e-14 Diastolic blood pressure; LUSC cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg24812749 chr6:127587940 RNF146 0.92 13.86 0.6 7.98e-35 Breast cancer; LUSC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg13607699 chr17:42295918 UBTF 0.52 8.23 0.41 4.32e-15 Total body bone mineral density; LUSC cis rs8017423 0.626 rs8003363 chr14:90826840 T/C cg04374321 chr14:90722782 PSMC1 -0.42 -6.23 -0.32 1.42e-9 Mortality in heart failure; LUSC cis rs6696846 0.777 rs6664397 chr1:205051871 C/T cg03948781 chr1:205179583 DSTYK 0.29 5.74 0.3 2.08e-8 Red blood cell count; LUSC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg06634786 chr22:41940651 POLR3H -0.55 -6.2 -0.32 1.66e-9 Vitiligo; LUSC cis rs2046867 0.818 rs11929144 chr3:72868234 T/C cg04365224 chr3:72788183 NA -0.45 -6.05 -0.31 3.93e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2324229 0.861 rs983087 chr6:83954264 T/C cg08257003 chr6:84140564 ME1 0.26 5.95 0.31 6.59e-9 Platelet-derived growth factor BB levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14031059 chr19:19626956 NDUFA13;TSSK6 -0.47 -6.26 -0.32 1.16e-9 Hepatitis; LUSC cis rs62400317 0.556 rs10948196 chr6:44959384 A/T cg20913747 chr6:44695427 NA -0.35 -5.72 -0.3 2.4e-8 Total body bone mineral density; LUSC cis rs2963155 0.518 rs862489 chr5:142634355 T/C cg17617527 chr5:142782415 NR3C1 0.7 8.24 0.41 3.96e-15 Breast cancer; LUSC cis rs11077998 0.967 rs4789782 chr17:80489323 G/T cg10255544 chr17:80519551 FOXK2 -0.39 -6.43 -0.33 4.54e-10 Reticulocyte fraction of red cells; LUSC cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg06784218 chr1:46089804 CCDC17 0.54 10.88 0.51 8.41e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg00945038 chr17:61921165 SMARCD2 0.54 9.39 0.46 9.68e-19 Prudent dietary pattern; LUSC cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg05283184 chr6:79620031 NA -0.45 -8.44 -0.42 9.95e-16 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg08888203 chr3:10149979 C3orf24 0.65 8.86 0.44 4.67e-17 Alzheimer's disease; LUSC trans rs61931739 0.534 rs4931772 chr12:34044590 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.77 0.51 2.06e-23 Morning vs. evening chronotype; LUSC cis rs6076065 0.748 rs1016628 chr20:23398738 C/G cg11657817 chr20:23433608 CST11 -0.51 -10.4 -0.49 3.83e-22 Facial morphology (factor 15, philtrum width); LUSC cis rs7000551 0.689 rs2449339 chr8:22387981 G/A cg12081754 chr8:22256438 SLC39A14 0.44 6.7 0.34 8.86e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg09796270 chr17:17721594 SREBF1 -0.42 -7.41 -0.38 1.01e-12 Total body bone mineral density; LUSC cis rs7178572 0.633 rs12901130 chr15:77848806 C/T cg22256960 chr15:77711686 NA -0.51 -7.41 -0.38 1.02e-12 Type 2 diabetes; LUSC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg04398451 chr17:18023971 MYO15A -0.48 -7.63 -0.39 2.43e-13 Total body bone mineral density; LUSC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg08847533 chr14:75593920 NEK9 0.81 14.12 0.61 8.1e-36 Height; LUSC cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.75 0.51 2.4e-23 Bladder cancer; LUSC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg02782426 chr3:40428986 ENTPD3 -0.39 -7.6 -0.38 3.05e-13 Renal cell carcinoma; LUSC trans rs61931739 0.534 rs10506120 chr12:34235603 G/A cg26384229 chr12:38710491 ALG10B 0.73 11.95 0.55 1.17e-27 Morning vs. evening chronotype; LUSC cis rs7512552 0.809 rs1694363 chr1:150368677 T/G cg15654264 chr1:150340011 RPRD2 0.67 10.69 0.51 3.79e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg00033643 chr7:134001901 SLC35B4 -0.4 -5.84 -0.3 1.26e-8 Mean platelet volume; LUSC cis rs2280018 0.526 rs1510148 chr16:15167379 T/A cg07549590 chr16:15018862 NA -0.57 -9.67 -0.47 1.13e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg09165964 chr15:75287851 SCAMP5 0.52 7.59 0.38 3.32e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs28647808 0.618 rs7025970 chr9:136267173 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs3540 0.597 rs7498113 chr15:91051192 C/G cg10434728 chr15:90938212 IQGAP1 -0.44 -8.87 -0.44 4.44e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs8072100 0.754 rs8081717 chr17:45653921 T/A cg04995722 chr7:26192034 NFE2L3 0.36 6.01 0.31 4.92e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11039100 0.920 rs12792905 chr11:5821544 G/C cg13902645 chr11:5959945 NA -0.53 -5.94 -0.31 7.09e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs2048656 0.535 rs2014514 chr8:9647196 A/T cg06636001 chr8:8085503 FLJ10661 0.51 7.59 0.38 3.1400000000000003e-13 Schizophrenia; LUSC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg06238570 chr21:40685208 BRWD1 0.46 7.08 0.36 8.78e-12 Cognitive function; LUSC cis rs765787 0.530 rs11854689 chr15:45516052 A/G cg25801113 chr15:45476975 SHF 0.34 7.0 0.36 1.37e-11 Uric acid levels; LUSC cis rs7917772 0.715 rs7077678 chr10:104438565 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.46 6.34 0.33 7.61e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs28655083 0.529 rs645878 chr16:77099974 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.38 6.15 0.32 2.24e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs8064299 0.597 rs4789097 chr17:72781208 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.93 -19.27 -0.73 3.69e-56 Monocyte count; LUSC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg06850241 chr22:41845214 NA -0.32 -5.81 -0.3 1.46e-8 Vitiligo; LUSC cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg13010199 chr12:38710504 ALG10B 0.63 9.67 0.47 1.14e-19 Bladder cancer; LUSC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs1577917 1.000 rs11759855 chr6:86610841 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs4969178 0.931 rs6501208 chr17:76395038 A/T cg20026190 chr17:76395443 PGS1 0.45 8.17 0.41 6.52e-15 HDL cholesterol levels; LUSC cis rs8044995 0.563 rs56331745 chr16:68368770 G/T cg09835421 chr16:68378352 PRMT7 -0.75 -8.42 -0.42 1.13e-15 Schizophrenia; LUSC cis rs7590720 1.000 rs4674048 chr2:216900023 G/A cg12620499 chr2:216877984 MREG 0.93 14.19 0.61 4.21e-36 Alcohol dependence; LUSC trans rs62238980 0.614 rs2006867 chr22:32384307 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs4466137 1.000 rs4466137 chr5:82985739 A/C cg16102102 chr5:83017553 HAPLN1 -0.89 -13.77 -0.6 1.79e-34 Prostate cancer; LUSC cis rs12900413 0.959 rs11632886 chr15:90322945 A/G cg24249390 chr15:90295951 MESP1 -0.43 -6.33 -0.33 7.69e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs2281845 0.826 rs4915215 chr1:201077212 C/T cg22815214 chr1:201083145 CACNA1S -0.49 -8.61 -0.43 3.03e-16 Permanent tooth development; LUSC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.89 0.35 2.81e-11 Tonsillectomy; LUSC cis rs2658782 0.789 rs3020057 chr11:93118515 C/T cg15737290 chr11:93063684 CCDC67 0.63 7.86 0.39 5.48e-14 Pulmonary function decline; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg07332563 chr6:291687 DUSP22 -0.51 -7.88 -0.4 4.82e-14 Menopause (age at onset); LUSC cis rs644799 0.710 rs11021311 chr11:95505227 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.05 0.61 1.44e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6940638 0.688 rs1028308 chr6:27129757 G/A cg09904177 chr6:26538194 HMGN4 -0.48 -6.91 -0.35 2.53e-11 Intelligence (multi-trait analysis); LUSC cis rs17270561 0.609 rs4711100 chr6:25741954 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs939658 0.805 rs11631590 chr15:79446199 C/T cg17916960 chr15:79447300 NA -0.54 -10.99 -0.52 3.33e-24 Refractive error; LUSC cis rs887829 0.694 rs6749496 chr2:234624286 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -8.12 -0.41 8.83e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs1044826 0.642 rs176983 chr3:139213755 G/A cg00490450 chr3:139108681 COPB2 0.46 6.99 0.36 1.51e-11 Obesity-related traits; LUSC cis rs6831352 0.729 rs4699718 chr4:100067791 G/A cg13256891 chr4:100009986 ADH5 -0.49 -6.37 -0.33 6.11e-10 Alcohol dependence; LUSC cis rs7043114 0.525 rs10761161 chr9:95262342 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.66 -0.34 1.12e-10 Height; LUSC cis rs2463822 0.844 rs7104149 chr11:62171627 A/G cg06239285 chr11:62104954 ASRGL1 -0.98 -10.33 -0.49 6.59e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04720380 chr1:93297552 RPL5 -0.45 -6.68 -0.34 9.84e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs8062405 0.824 rs62034319 chr16:28532188 T/G cg16576597 chr16:28551801 NUPR1 0.28 5.72 0.3 2.37e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11098499 0.909 rs71614422 chr4:120359340 G/A cg09307838 chr4:120376055 NA 0.78 11.21 0.52 5.56e-25 Corneal astigmatism; LUSC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg15556689 chr8:8085844 FLJ10661 0.58 8.76 0.43 9.73e-17 Mood instability; LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.88 0.48 2.37e-20 Bipolar disorder; LUSC cis rs6580649 0.941 rs3742074 chr12:48457385 C/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.07 -0.32 3.47e-9 Lung cancer; LUSC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg17385448 chr1:15911702 AGMAT 0.36 5.97 0.31 5.92e-9 Systolic blood pressure; LUSC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg15448220 chr1:150897856 SETDB1 0.41 6.06 0.31 3.75e-9 Melanoma; LUSC cis rs7223966 1.000 rs73337598 chr17:61732576 T/C cg05941027 chr17:61774174 LIMD2 0.22 5.87 0.31 1.04e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs17270561 0.609 rs2154218 chr6:25776290 T/C cg17691542 chr6:26056736 HIST1H1C 0.5 6.94 0.35 2.07e-11 Iron status biomarkers; LUSC trans rs61931739 0.500 rs6488215 chr12:34434803 A/T cg13010199 chr12:38710504 ALG10B 0.58 9.23 0.45 3.24e-18 Morning vs. evening chronotype; LUSC cis rs2204008 0.549 rs12312109 chr12:38228251 G/T cg26384229 chr12:38710491 ALG10B -0.6 -8.96 -0.44 2.41e-17 Bladder cancer; LUSC cis rs7267979 1.000 rs2387884 chr20:25379069 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1577917 1.000 rs12196037 chr6:86694631 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.96 -0.36 1.8e-11 Response to antipsychotic treatment; LUSC cis rs929354 0.707 rs1182445 chr7:157024428 C/G cg17757837 chr7:157058334 UBE3C -0.82 -13.31 -0.59 1.01e-32 Body mass index; LUSC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg23205692 chr1:25664452 TMEM50A 0.42 6.26 0.32 1.21e-9 Erythrocyte sedimentation rate; LUSC cis rs17102423 0.826 rs12887607 chr14:65596887 G/A cg11161011 chr14:65562177 MAX -0.73 -11.0 -0.52 3.18e-24 Obesity-related traits; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg02951883 chr7:2050386 MAD1L1 -0.38 -6.72 -0.35 7.97e-11 Bipolar disorder and schizophrenia; LUSC cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg08999081 chr20:33150536 PIGU 0.54 10.57 0.5 1.03e-22 Coronary artery disease; LUSC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg08847533 chr14:75593920 NEK9 0.84 15.4 0.64 8.01e-41 Height; LUSC cis rs983392 0.709 rs7928895 chr11:59975165 G/A cg02771260 chr11:59836817 MS4A3 -0.37 -6.01 -0.31 4.95e-9 Alzheimer's disease (late onset); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg21036854 chr14:77506705 NA -0.4 -6.07 -0.32 3.5e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs3770081 1.000 rs58898686 chr2:86216909 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.98 -6.43 -0.33 4.34e-10 Facial emotion recognition (sad faces); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02184338 chr7:101331866 NA -0.52 -6.5 -0.34 2.91e-10 Bipolar disorder and schizophrenia; LUSC cis rs17270561 0.525 rs12201678 chr6:25978993 C/T cg16482183 chr6:26056742 HIST1H1C 1.06 13.53 0.6 1.45e-33 Iron status biomarkers; LUSC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -7.45 -0.38 8.32e-13 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg03146154 chr1:46216737 IPP 0.57 8.51 0.42 6.03e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4588572 0.644 rs1428864 chr5:77780263 C/T cg11547950 chr5:77652471 NA -0.4 -5.81 -0.3 1.48e-8 Triglycerides; LUSC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.56 0.38 3.81e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7172677 1.000 rs2029520 chr15:75415768 A/G cg14664628 chr15:75095509 CSK -0.45 -5.82 -0.3 1.35e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg22676075 chr6:135203613 NA -0.64 -10.15 -0.49 2.93e-21 High light scatter reticulocyte percentage of red cells; LUSC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg06808227 chr14:105710500 BRF1 -0.7 -11.07 -0.52 1.8e-24 Mean platelet volume;Platelet distribution width; LUSC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg15147215 chr3:52552868 STAB1 -0.32 -6.36 -0.33 6.45e-10 Bipolar disorder; LUSC cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.82 0.3 1.34e-8 Rheumatoid arthritis; LUSC trans rs853679 0.546 rs200950 chr6:27835772 A/G cg01620082 chr3:125678407 NA -0.75 -7.26 -0.37 2.81e-12 Depression; LUSC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg24549020 chr5:56110836 MAP3K1 0.49 5.96 0.31 6.33e-9 Initial pursuit acceleration; LUSC trans rs7618501 0.633 rs9853222 chr3:50022926 T/C cg21659725 chr3:3221576 CRBN 0.63 10.36 0.49 5.2e-22 Intelligence (multi-trait analysis); LUSC trans rs62238980 0.614 rs743763 chr22:32458861 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg08949735 chr16:89699720 DPEP1 -0.23 -5.81 -0.3 1.46e-8 Vitiligo; LUSC cis rs977987 0.806 rs4888390 chr16:75400320 G/A cg04384234 chr16:75411784 CFDP1 -0.42 -6.94 -0.36 2e-11 Dupuytren's disease; LUSC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg03690763 chr11:133734501 NA 0.37 6.71 0.34 8.52e-11 Childhood ear infection; LUSC cis rs7119038 0.865 rs7117261 chr11:118741157 T/C cg19308663 chr11:118741387 NA -0.35 -5.93 -0.31 7.59e-9 Sjögren's syndrome; LUSC cis rs7216064 0.953 rs1966410 chr17:65837215 T/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.44 -0.46 6.6e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs4280164 0.551 rs8008406 chr14:24811159 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 0.53 6.87 0.35 3.25e-11 Parent of origin effect on language impairment (paternal); LUSC cis rs7267979 1.000 rs6050598 chr20:25397257 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.69 0.75 8.37e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg11645453 chr3:52864694 ITIH4 0.35 7.99 0.4 2.28e-14 Bipolar disorder; LUSC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.43 0.46 7.11e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg07701084 chr6:150067640 NUP43 0.56 8.39 0.42 1.36e-15 Lung cancer; LUSC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg17848003 chr1:3704513 LRRC47 0.34 6.5 0.34 2.9e-10 Red cell distribution width; LUSC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg20307385 chr11:47447363 PSMC3 -0.44 -5.8 -0.3 1.5e-8 Subjective well-being; LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC cis rs3820928 0.904 rs60906902 chr2:227760034 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.36e-13 Pulmonary function; LUSC cis rs1348850 0.645 rs4893963 chr2:178430747 A/G cg22681709 chr2:178499509 PDE11A 0.38 5.84 0.3 1.26e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs79387448 0.745 rs7582378 chr2:103162263 C/A cg09003973 chr2:102972529 NA 0.88 8.56 0.42 4.18e-16 Gut microbiota (bacterial taxa); LUSC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg26597838 chr10:835615 NA 0.84 11.81 0.54 3.83e-27 Eosinophil percentage of granulocytes; LUSC trans rs12692738 0.526 rs355850 chr2:165626043 C/T cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs67696533 0.600 rs879829 chr20:31114479 G/A cg13636640 chr20:31349939 DNMT3B 0.46 6.11 0.32 2.71e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -9.91 -0.48 1.76e-20 Glomerular filtration rate (creatinine); LUSC cis rs10979 1.000 rs9403505 chr6:143885841 A/G cg25407410 chr6:143891975 LOC285740 -0.73 -11.85 -0.54 2.87e-27 Hypospadias; LUSC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg07256732 chr16:621771 PIGQ -0.35 -6.18 -0.32 1.9e-9 Height; LUSC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg15181151 chr6:150070149 PCMT1 0.26 5.81 0.3 1.43e-8 Lung cancer; LUSC cis rs6445797 0.589 rs11715395 chr3:56681949 G/A cg13792233 chr3:56591045 CCDC66 0.41 5.68 0.3 2.89e-8 Gastritis; LUSC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg19257562 chr1:2043853 PRKCZ 0.31 6.19 0.32 1.77e-9 Height; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.73 -0.39 1.31e-13 Lymphocyte counts; LUSC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg14703610 chr5:56206110 C5orf35 0.4 5.73 0.3 2.23e-8 Coronary artery disease; LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg21724239 chr8:58056113 NA 0.83 10.01 0.48 8.33e-21 Developmental language disorder (linguistic errors); LUSC cis rs4803468 1.000 rs3810175 chr19:41904396 C/T cg05360949 chr19:41903737 BCKDHA;EXOSC5 -0.4 -5.67 -0.3 3.15e-8 Height; LUSC cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.33 -5.66 -0.3 3.21e-8 Intelligence (multi-trait analysis); LUSC cis rs7712401 0.562 rs2407403 chr5:122174031 C/T cg19077854 chr5:122220652 SNX24 0.41 9.33 0.45 1.47e-18 Mean platelet volume; LUSC cis rs3820928 1.000 rs7592387 chr2:227777095 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.8e-14 Pulmonary function; LUSC cis rs7584330 0.910 rs880932 chr2:238396963 A/G cg16989719 chr2:238392110 NA -0.42 -7.23 -0.37 3.41e-12 Prostate cancer; LUSC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg08847533 chr14:75593920 NEK9 0.82 15.25 0.64 3.1e-40 Height; LUSC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.32 0.33 8.29e-10 Height; LUSC cis rs1775715 0.737 rs2799000 chr10:32124894 C/T cg18675610 chr10:32216311 ARHGAP12 0.29 6.34 0.33 7.56e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7582180 0.585 rs6736311 chr2:100950599 C/G cg08017756 chr2:100939284 LONRF2 -0.44 -8.27 -0.41 3.33e-15 Intelligence (multi-trait analysis); LUSC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg20203395 chr5:56204925 C5orf35 0.52 7.24 0.37 3.2e-12 Coronary artery disease; LUSC cis rs6681460 1.000 rs964574 chr1:67062885 T/C cg02459107 chr1:67143332 SGIP1 0.47 8.83 0.44 5.8e-17 Presence of antiphospholipid antibodies; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02004021 chr12:95868393 METAP2 0.47 6.47 0.33 3.41e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg20933634 chr6:27740509 NA 0.41 5.88 0.31 9.8e-9 Parkinson's disease; LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.79 0.39 8.73e-14 Prudent dietary pattern; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg16132339 chr22:24313637 DDTL;DDT 0.39 6.25 0.32 1.22e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg20307385 chr11:47447363 PSMC3 -0.45 -5.78 -0.3 1.67e-8 Subjective well-being; LUSC cis rs12594515 0.874 rs8032878 chr15:45998015 A/G cg19682013 chr15:45996608 NA 0.39 5.84 0.3 1.24e-8 Waist circumference;Weight; LUSC cis rs250677 0.958 rs36070 chr5:148417240 T/C cg18129178 chr5:148520854 ABLIM3 -0.66 -10.32 -0.49 7.39e-22 Breast cancer; LUSC cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg18132916 chr6:79620363 NA -0.4 -6.14 -0.32 2.4e-9 Intelligence (multi-trait analysis); LUSC cis rs611744 0.658 rs2443774 chr8:109064957 T/C cg18478394 chr8:109455254 TTC35 0.41 6.01 0.31 4.98e-9 Dupuytren's disease; LUSC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg18402987 chr7:1209562 NA 0.65 7.38 0.37 1.23e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9325144 0.647 rs12831609 chr12:39051576 C/A cg13010199 chr12:38710504 ALG10B -0.51 -7.77 -0.39 9.69e-14 Morning vs. evening chronotype; LUSC cis rs35995292 0.534 rs28460817 chr7:38921917 T/C cg19327137 chr7:38886074 VPS41 0.55 10.38 0.49 4.61e-22 Subjective well-being (multi-trait analysis); LUSC cis rs7786808 0.608 rs9692003 chr7:158204696 G/A cg01191920 chr7:158217561 PTPRN2 0.42 8.35 0.42 1.81e-15 Obesity-related traits; LUSC cis rs2273669 0.667 rs75942063 chr6:109352545 G/A cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 9.1e-9 Prostate cancer; LUSC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg27165867 chr14:105738592 BRF1 -0.5 -7.46 -0.38 7.35e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg07677032 chr17:61819896 STRADA 0.53 8.94 0.44 2.77e-17 Prudent dietary pattern; LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.05 0.64 1.96e-39 Platelet count; LUSC trans rs7647973 0.626 rs7637711 chr3:49829653 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.58 6.9 0.35 2.67e-11 Menarche (age at onset); LUSC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg15744005 chr10:104629667 AS3MT -0.34 -6.89 -0.35 2.84e-11 Arsenic metabolism; LUSC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.88 -0.51 8.12e-24 Schizophrenia; LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg10621924 chr7:39171070 POU6F2 0.47 7.46 0.38 7.6e-13 IgG glycosylation; LUSC cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs6489882 0.703 rs10774672 chr12:113360737 G/T cg20102336 chr12:113376681 OAS3 -0.4 -5.67 -0.3 3.1e-8 Chronic lymphocytic leukemia; LUSC cis rs7953249 1.000 rs7953249 chr12:121403724 A/G cg02403541 chr12:121454288 C12orf43 0.62 9.53 0.46 3.44e-19 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs116988415 1.000 rs1012376 chr14:65294790 C/T cg00114569 chr14:65239327 SPTB 0.53 5.71 0.3 2.53e-8 Daytime sleep phenotypes; LUSC trans rs1448094 0.817 rs11117115 chr12:86331021 A/G cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.91 0.51 6.64e-24 Monocyte percentage of white cells; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.55 0.42 4.4e-16 Prudent dietary pattern; LUSC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg27286337 chr10:134555280 INPP5A 0.92 11.97 0.55 1.05e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.82 0.3 1.37e-8 Tonsillectomy; LUSC cis rs6489882 0.867 rs6489876 chr12:113368055 G/A cg20102336 chr12:113376681 OAS3 -0.4 -5.74 -0.3 2.17e-8 Chronic lymphocytic leukemia; LUSC cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.93 -0.51 5.64e-24 Alzheimer's disease (late onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01435196 chr19:46009946 VASP 0.47 7.21 0.37 3.67e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs554111 0.656 rs6685914 chr1:21362378 G/A cg01072550 chr1:21505969 NA 0.4 6.14 0.32 2.29e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs1577917 1.000 rs1337844 chr6:86677273 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -8.13 -0.41 8.66e-15 Response to antipsychotic treatment; LUSC cis rs6546550 0.901 rs11893500 chr2:70154187 T/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.31 -0.37 2.02e-12 Prevalent atrial fibrillation; LUSC cis rs4888262 0.507 rs9888976 chr16:74580924 C/T cg01733217 chr16:74700730 RFWD3 0.74 11.89 0.55 1.99e-27 Testicular germ cell tumor; LUSC cis rs10992471 0.627 rs4744138 chr9:95291909 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.44 -0.33 4.18e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs748404 0.697 rs492743 chr15:43560945 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.75 0.3 2.04e-8 Lung cancer; LUSC trans rs6968419 1.000 rs10245914 chr7:115817585 A/G cg05268155 chr13:24844880 SPATA13 0.35 6.01 0.31 4.81e-9 Intraocular pressure; LUSC cis rs1448094 0.872 rs7311150 chr12:86435989 A/T cg02569458 chr12:86230093 RASSF9 0.36 5.83 0.3 1.34e-8 Major depressive disorder; LUSC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg13770153 chr20:60521292 NA -0.48 -6.91 -0.35 2.47e-11 Body mass index; LUSC cis rs9361491 0.510 rs1507151 chr6:79483246 T/C cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.06 -0.31 3.62e-9 Intelligence (multi-trait analysis); LUSC cis rs3829109 0.564 rs11145910 chr9:139300494 A/G cg14019695 chr9:139328340 INPP5E 0.38 5.89 0.31 9.48e-9 Peak insulin response;Acute insulin response; LUSC cis rs12545109 0.800 rs990301 chr8:57406021 G/C cg09654669 chr8:57350985 NA -0.58 -7.79 -0.39 8.28e-14 Obesity-related traits; LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs9399135 0.967 rs9389258 chr6:135361140 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.05 0.44 1.18e-17 Red blood cell count; LUSC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg18230493 chr5:56204884 C5orf35 -0.91 -13.91 -0.61 4.93e-35 Initial pursuit acceleration; LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg02018176 chr4:1364513 KIAA1530 0.48 8.47 0.42 8.06e-16 Obesity-related traits; LUSC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg04800585 chr6:26043546 HIST1H2BB 0.41 5.8 0.3 1.54e-8 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.712 rs2054601 chr15:72184968 T/C cg16672083 chr15:72433130 SENP8 -0.5 -7.37 -0.37 1.33e-12 Red blood cell count; LUSC cis rs4285028 0.699 rs6771068 chr3:121478745 A/T cg01951420 chr3:121553821 IQCB1;EAF2 0.92 12.51 0.56 1.02e-29 Multiple sclerosis; LUSC cis rs7166081 0.688 rs4776361 chr15:67762056 G/A cg05925327 chr15:68127851 NA -0.38 -5.9 -0.31 8.84e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs699371 0.507 rs10149538 chr14:74925397 A/G cg16374328 chr14:74960395 NPC2;ISCA2 0.37 6.01 0.31 4.8e-9 Height; LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg06873352 chr17:61820015 STRADA 0.71 12.54 0.57 8.15e-30 Prudent dietary pattern; LUSC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg05347473 chr6:146136440 FBXO30 0.56 9.62 0.47 1.66e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg14019146 chr3:50243930 SLC38A3 0.36 8.29 0.41 2.81e-15 Body mass index; LUSC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -7.32 -0.37 1.91e-12 Developmental language disorder (linguistic errors); LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg26668828 chr6:292823 DUSP22 -0.73 -12.11 -0.55 3.02e-28 Menopause (age at onset); LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs7647973 0.593 rs28535523 chr3:49848414 C/T cg13072238 chr3:49761600 GMPPB 0.68 8.74 0.43 1.11e-16 Menarche (age at onset); LUSC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.09 -0.36 8.12e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg14895029 chr7:2775587 GNA12 0.42 6.59 0.34 1.68e-10 Height; LUSC cis rs1728785 1.000 rs1645928 chr16:68590610 G/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.67 -0.3 3.05e-8 Ulcerative colitis; LUSC cis rs2777491 1.000 rs2777491 chr15:41735710 T/G cg18705301 chr15:41695430 NDUFAF1 -0.71 -12.99 -0.58 1.63e-31 Ulcerative colitis; LUSC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg06640241 chr16:89574553 SPG7 0.7 11.09 0.52 1.49e-24 Multiple myeloma (IgH translocation); LUSC cis rs10751667 0.666 rs10902241 chr11:949129 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.46 0.33 3.71e-10 Alzheimer's disease (late onset); LUSC cis rs6700896 0.931 rs7546242 chr1:66093030 C/T cg04111102 chr1:66153794 NA 0.31 6.84 0.35 3.68e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10883723 1.000 rs10883723 chr10:104225832 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.8 11.76 0.54 5.94e-27 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1044826 1.000 rs2349059 chr3:139176932 C/T cg00490450 chr3:139108681 COPB2 0.5 6.61 0.34 1.5e-10 Obesity-related traits; LUSC cis rs8044995 0.563 rs1110572 chr16:68396119 A/G cg05110241 chr16:68378359 PRMT7 -0.77 -8.51 -0.42 5.76e-16 Schizophrenia; LUSC cis rs9309711 0.813 rs11690865 chr2:3471950 C/T cg10845886 chr2:3471009 TTC15 -0.6 -7.83 -0.39 6.63e-14 Neurofibrillary tangles; LUSC cis rs10089 1.000 rs13356473 chr5:127478250 T/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.88 12.56 0.57 6.54e-30 Ileal carcinoids; LUSC cis rs10832963 1.000 rs10832956 chr11:18645668 A/G cg09201001 chr11:18656081 SPTY2D1 0.91 14.82 0.63 1.53e-38 Breast cancer; LUSC cis rs9888739 0.920 rs12920597 chr16:31304382 C/T cg15817542 chr16:31343056 ITGAM -0.54 -6.08 -0.32 3.28e-9 Systemic lupus erythematosus; LUSC cis rs4595586 0.545 rs12815047 chr12:39380901 A/G cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg11247378 chr22:39784982 NA -0.67 -13.66 -0.6 4.72e-34 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg14552801 chr7:65878734 NA -0.43 -6.14 -0.32 2.38e-9 Aortic root size; LUSC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg03609598 chr5:56110824 MAP3K1 -0.42 -6.12 -0.32 2.62e-9 Initial pursuit acceleration; LUSC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.87 0.63 9.38e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9790314 0.967 rs463928 chr3:161087734 A/T cg03342759 chr3:160939853 NMD3 -0.47 -7.72 -0.39 1.4e-13 Morning vs. evening chronotype; LUSC cis rs7267979 1.000 rs6132835 chr20:25434667 A/G cg08601574 chr20:25228251 PYGB 0.42 6.37 0.33 6.26e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7267979 0.966 rs2482918 chr20:25412135 C/T cg03522245 chr20:25566470 NINL -0.35 -5.74 -0.3 2.18e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.81 0.43 6.77e-17 Axial length; LUSC trans rs4295623 0.585 rs34421088 chr8:11589042 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.27 -0.32 1.13e-9 Morning vs. evening chronotype; LUSC cis rs354225 0.544 rs10183867 chr2:54812722 C/G cg26097391 chr2:54893211 SPTBN1 0.43 6.47 0.33 3.5e-10 Schizophrenia; LUSC cis rs662064 0.962 rs6540933 chr1:10547263 C/T cg20482658 chr1:10539492 PEX14 -0.33 -6.65 -0.34 1.23e-10 Asthma; LUSC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC cis rs17253792 0.822 rs28481586 chr14:56053863 C/G cg01858014 chr14:56050164 KTN1 -0.86 -7.18 -0.37 4.47e-12 Putamen volume; LUSC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg17143192 chr8:8559678 CLDN23 0.59 8.49 0.42 6.84e-16 Obesity-related traits; LUSC cis rs4843185 0.733 rs1049868 chr16:85706633 A/G cg05245094 chr16:85669572 KIAA0182 0.39 5.79 0.3 1.63e-8 Platelet distribution width; LUSC cis rs12210905 0.925 rs11966939 chr6:27003749 T/C cg23155468 chr6:27110703 HIST1H2BK -0.69 -6.01 -0.31 4.99e-9 Hip circumference adjusted for BMI; LUSC cis rs9831754 0.906 rs4680929 chr3:78387591 T/A cg06138941 chr3:78371609 NA -0.7 -9.49 -0.46 4.42e-19 Calcium levels; LUSC cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg14689365 chr7:158441557 NCAPG2 0.5 7.15 0.36 5.43e-12 Height; LUSC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg07636037 chr3:49044803 WDR6 1.04 18.83 0.72 2.12e-54 Parkinson's disease; LUSC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg05890377 chr2:74357713 NA 0.7 12.27 0.56 8.09e-29 Gestational age at birth (maternal effect); LUSC cis rs765787 0.530 rs2554456 chr15:45521138 A/C cg25801113 chr15:45476975 SHF 0.35 7.09 0.36 8.23e-12 Uric acid levels; LUSC cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.39 -6.25 -0.32 1.23e-9 IgG glycosylation; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg14004847 chr7:1930337 MAD1L1 -0.66 -10.61 -0.5 7.67e-23 Bipolar disorder and schizophrenia; LUSC cis rs8077889 0.917 rs72836559 chr17:41913529 C/T cg26893861 chr17:41843967 DUSP3 0.94 14.48 0.62 3.22e-37 Triglycerides; LUSC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg07701084 chr6:150067640 NUP43 0.57 8.8 0.43 7.45e-17 Lung cancer; LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs9906944 0.707 rs4794020 chr17:47111399 C/T cg14634687 chr17:47094252 IGF2BP1 0.31 6.54 0.34 2.26e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg23188684 chr11:67383651 NA 0.33 5.8 0.3 1.56e-8 Mean corpuscular volume; LUSC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg15556689 chr8:8085844 FLJ10661 0.65 10.59 0.5 8.58e-23 Mood instability; LUSC cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg07274523 chr3:49395745 GPX1 0.67 10.28 0.49 9.91e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9287719 0.967 rs4470306 chr2:10743998 C/T cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs3774830 0.714 rs7657964 chr4:5466327 C/G cg26943120 chr4:5472116 STK32B -0.29 -5.76 -0.3 1.89e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs13217239 0.646 rs2142685 chr6:27054497 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -5.9 -0.31 8.86e-9 Schizophrenia; LUSC cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg14993813 chr1:46806288 NSUN4 -0.52 -7.23 -0.37 3.22e-12 Menopause (age at onset); LUSC cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.27 -0.37 2.57e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9341808 0.935 rs9343974 chr6:80924645 A/G cg08355045 chr6:80787529 NA 0.54 9.48 0.46 4.94e-19 Sitting height ratio; LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg22868518 chr11:507468 RNH1 -0.58 -5.76 -0.3 1.95e-8 Body mass index; LUSC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg23985595 chr17:80112537 CCDC57 0.31 5.88 0.31 9.71e-9 Life satisfaction; LUSC cis rs6121246 0.559 rs6119652 chr20:30259445 C/G cg13852791 chr20:30311386 BCL2L1 0.96 14.98 0.63 3.73e-39 Mean corpuscular hemoglobin; LUSC cis rs7659604 0.935 rs73844280 chr4:122664687 G/A cg19748678 chr4:122722346 EXOSC9 0.48 7.47 0.38 7.05e-13 Type 2 diabetes; LUSC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg22508957 chr16:3507546 NAT15 0.45 6.44 0.33 4.28e-10 Body mass index (adult); LUSC trans rs11148252 0.774 rs9536066 chr13:52983981 A/G cg18335740 chr13:41363409 SLC25A15 0.6 10.11 0.48 3.71e-21 Lewy body disease; LUSC cis rs12220238 0.915 rs75467340 chr10:75907318 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.9 0.35 2.58e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs5769707 0.967 rs9616713 chr22:50049109 G/A cg20744362 chr22:50050164 C22orf34 0.4 8.3 0.41 2.56e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12410462 0.581 rs113827839 chr1:227547180 C/T cg23173402 chr1:227635558 NA 0.55 6.39 0.33 5.42e-10 Major depressive disorder; LUSC cis rs17604090 0.701 rs60930239 chr7:29688544 A/G cg19413766 chr7:29689036 LOC646762 -0.54 -6.77 -0.35 5.88e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs11155671 0.530 rs2342770 chr6:150216685 C/T cg09699651 chr6:150184138 LRP11 0.44 6.98 0.36 1.61e-11 Testicular germ cell tumor; LUSC trans rs11006747 0.539 rs6481485 chr10:28123364 A/G cg26606327 chr7:98972104 ARPC1B 0.43 5.99 0.31 5.45e-9 Obesity-related traits; LUSC cis rs1577917 1.000 rs6940458 chr6:86644992 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.33 -0.33 8.06e-10 Response to antipsychotic treatment; LUSC cis rs7246967 0.611 rs3951785 chr19:22851928 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC trans rs62238980 0.614 rs117067740 chr22:32407944 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs2486288 0.656 rs1719232 chr15:45572072 A/G cg04036182 chr15:45458818 NA -0.36 -5.7 -0.3 2.69e-8 Glomerular filtration rate; LUSC cis rs3808502 0.527 rs2736374 chr8:11113828 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.87 -0.31 1.07e-8 Neuroticism; LUSC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg02931644 chr1:25747376 RHCE -0.34 -6.14 -0.32 2.38e-9 Erythrocyte sedimentation rate; LUSC cis rs17540621 1.000 rs114977142 chr2:47196104 C/T cg23978866 chr2:47230407 TTC7A -0.92 -6.91 -0.35 2.44e-11 Response to statin therapy; LUSC cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.82 -0.51 1.38e-23 Alzheimer's disease (late onset); LUSC cis rs67478160 0.634 rs2024669 chr14:104275602 G/C cg01849466 chr14:104193079 ZFYVE21 -0.56 -9.2 -0.45 4.02e-18 Schizophrenia; LUSC cis rs8060686 0.641 rs9932251 chr16:68131732 G/A cg05110241 chr16:68378359 PRMT7 -0.51 -6.12 -0.32 2.69e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.96 0.51 4.51e-24 Menopause (age at onset); LUSC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg27121462 chr16:89883253 FANCA 0.39 5.91 0.31 8.6e-9 Vitiligo; LUSC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg06238570 chr21:40685208 BRWD1 0.49 7.54 0.38 4.4e-13 Cognitive function; LUSC cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg18681998 chr4:17616180 MED28 0.84 15.35 0.64 1.29e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg20135002 chr11:47629003 NA -0.5 -7.94 -0.4 3.16e-14 Subjective well-being; LUSC trans rs1997103 1.000 rs2177805 chr7:55404381 T/A cg20935933 chr6:143382018 AIG1 0.5 7.27 0.37 2.61e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs28374715 0.528 rs7178360 chr15:41631175 T/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -22.54 -0.78 4.9e-69 Ulcerative colitis; LUSC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg01416388 chr22:39784598 NA -0.39 -5.78 -0.3 1.73e-8 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg11965913 chr1:205819406 PM20D1 -0.47 -6.7 -0.34 9.06e-11 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg04248312 chr19:17393744 ANKLE1 -1.0 -16.83 -0.68 1.77e-46 Systemic lupus erythematosus; LUSC cis rs17001868 0.568 rs9611315 chr22:40736900 A/T cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC trans rs1422110 0.572 rs6884343 chr5:85444051 G/T cg01787110 chr1:109008453 NBPF6 0.52 8.82 0.43 6.53e-17 Attention function in attention deficit hyperactive disorder; LUSC cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg12935359 chr14:103987150 CKB -0.51 -8.2 -0.41 5.2e-15 Body mass index; LUSC cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.09 20.67 0.75 1.06e-61 Cognitive ability; LUSC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg16325326 chr1:53192061 ZYG11B 1.03 21.43 0.76 1.1e-64 Monocyte count; LUSC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg05340658 chr4:99064831 C4orf37 0.61 10.59 0.5 8.51e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg12011299 chr4:100065546 ADH4 -0.69 -10.77 -0.51 2.13e-23 Alcohol dependence; LUSC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg18827107 chr12:86230957 RASSF9 0.43 6.67 0.34 1.07e-10 Major depressive disorder; LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.99 -0.31 5.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg26119090 chr2:26468346 HADHA;HADHB 1.08 16.51 0.67 3.51e-45 Gut microbiome composition (summer); LUSC cis rs853679 0.546 rs36116761 chr6:27818482 C/G cg26958806 chr6:27640298 NA 0.83 6.57 0.34 1.94e-10 Depression; LUSC cis rs11098499 0.708 rs11732686 chr4:120252330 C/A cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.12e-12 Motion sickness; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg13047869 chr3:10149882 C3orf24 0.63 9.1 0.45 8.57e-18 Alzheimer's disease; LUSC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg23711669 chr6:146136114 FBXO30 -0.9 -17.37 -0.69 1.38e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs10754283 0.870 rs2390764 chr1:90112827 T/G cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg02777633 chr3:64009154 PSMD6 0.38 6.1 0.32 2.96e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7216064 1.000 rs12451511 chr17:65874861 T/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs9462027 0.628 rs2764211 chr6:34704613 C/T cg07306190 chr6:34760872 UHRF1BP1 0.33 5.83 0.3 1.34e-8 Systemic lupus erythematosus; LUSC trans rs7746199 0.736 rs67652222 chr6:27586220 C/T cg01620082 chr3:125678407 NA -0.77 -7.12 -0.36 6.8e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9329289 0.851 rs61835719 chr10:2543390 A/G cg05625103 chr10:2543513 NA 0.37 5.73 0.3 2.21e-8 Age-related hearing impairment; LUSC cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg12310025 chr6:25882481 NA -0.53 -9.71 -0.47 8.67e-20 Blood metabolite levels; LUSC cis rs2455601 0.573 rs2653573 chr11:8989874 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.55 -0.34 2.12e-10 Schizophrenia; LUSC cis rs10203711 0.933 rs4994754 chr2:239567218 A/G cg14580085 chr2:239553406 NA 0.41 6.99 0.36 1.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg14159672 chr1:205819179 PM20D1 -0.45 -6.12 -0.32 2.63e-9 Parkinson's disease; LUSC cis rs6714710 0.603 rs35255677 chr2:98567820 G/A cg26665480 chr2:98280029 ACTR1B 0.6 8.76 0.43 9.72e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs76878669 0.561 rs12420203 chr11:66163794 T/C cg18002602 chr11:66138449 SLC29A2 0.45 7.98 0.4 2.43e-14 Educational attainment (years of education); LUSC cis rs637571 0.510 rs12575663 chr11:65574535 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -6.03 -0.31 4.43e-9 Eosinophil percentage of white cells; LUSC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg25566285 chr7:158114605 PTPRN2 0.35 6.53 0.34 2.52e-10 Calcium levels; LUSC cis rs2637266 0.935 rs2583057 chr10:78396019 C/T cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.95e-13 Pulmonary function; LUSC cis rs1577917 0.958 rs2121594 chr6:86576854 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.89 -0.35 2.77e-11 Response to antipsychotic treatment; LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg16606324 chr3:10149918 C3orf24 0.62 9.08 0.44 9.81e-18 Alzheimer's disease; LUSC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC cis rs11690935 0.921 rs3770445 chr2:172708919 T/C cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.6 -0.62 1.11e-37 Schizophrenia; LUSC cis rs367943 0.712 rs1607159 chr5:112681044 C/A cg12552261 chr5:112820674 MCC 0.37 6.12 0.32 2.62e-9 Type 2 diabetes; LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.58 10.2 0.49 1.95e-21 Bipolar disorder; LUSC cis rs2806561 0.704 rs636940 chr1:23522967 A/T cg12483005 chr1:23474871 LUZP1 0.45 6.92 0.35 2.28e-11 Height; LUSC cis rs7647973 0.961 rs4955443 chr3:49286618 T/G cg07636037 chr3:49044803 WDR6 0.71 9.31 0.45 1.79e-18 Menarche (age at onset); LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.79 0.6 1.47e-34 Alzheimer's disease; LUSC cis rs3008870 1.000 rs11208976 chr1:67434411 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg04414720 chr1:150670196 GOLPH3L -0.53 -8.39 -0.42 1.35e-15 Melanoma; LUSC cis rs1153858 0.668 rs63603561 chr15:45593323 T/A cg21132104 chr15:45694354 SPATA5L1 -0.52 -6.91 -0.35 2.54e-11 Homoarginine levels; LUSC cis rs67696533 0.600 rs733852 chr20:31111094 G/T cg13636640 chr20:31349939 DNMT3B 0.47 6.21 0.32 1.55e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9560113 0.550 rs1163633 chr13:112231561 G/T cg10483660 chr13:112241077 NA -0.4 -7.26 -0.37 2.81e-12 Menarche (age at onset); LUSC cis rs6076065 0.723 rs6137940 chr20:23397491 G/C cg11657817 chr20:23433608 CST11 0.44 8.22 0.41 4.64e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg13939156 chr17:80058883 NA -0.33 -6.54 -0.34 2.31e-10 Life satisfaction; LUSC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs6598955 0.671 rs11247909 chr1:26640135 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.17 -0.41 6.29e-15 Obesity-related traits; LUSC cis rs1577917 1.000 rs12212733 chr6:86726013 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.08 -0.36 8.81e-12 Response to antipsychotic treatment; LUSC trans rs1005277 0.565 rs2474565 chr10:38380828 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.45 -0.46 6.15e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.18 0.45 4.79e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg04450456 chr4:17643702 FAM184B 0.35 5.77 0.3 1.81e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg24531977 chr5:56204891 C5orf35 -0.89 -13.8 -0.6 1.31e-34 Initial pursuit acceleration; LUSC cis rs2404602 0.647 rs2404604 chr15:76991105 A/G cg23625390 chr15:77176239 SCAPER -0.66 -9.94 -0.48 1.47e-20 Blood metabolite levels; LUSC cis rs28830936 1.000 rs11637341 chr15:41955825 G/T cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.36 -0.33 6.8e-10 Diastolic blood pressure; LUSC cis rs983392 0.667 rs662196 chr11:59942757 C/T cg24026212 chr11:59952134 MS4A6A 0.34 6.03 0.31 4.27e-9 Alzheimer's disease (late onset); LUSC cis rs34421088 0.560 rs2248315 chr8:11397086 T/A cg21775007 chr8:11205619 TDH -0.53 -8.05 -0.4 1.52e-14 Neuroticism; LUSC cis rs7824557 0.602 rs11784544 chr8:11204503 G/C cg21293242 chr8:11204541 TDH 0.31 5.66 0.3 3.34e-8 Retinal vascular caliber; LUSC cis rs10761482 0.861 rs1814117 chr10:62099897 C/T cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs7258465 0.931 rs875396 chr19:18611147 A/G cg11102782 chr19:18549136 ISYNA1 -0.36 -6.79 -0.35 5.04e-11 Breast cancer; LUSC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg04025307 chr7:1156635 C7orf50 -0.4 -6.37 -0.33 6.26e-10 Longevity;Endometriosis; LUSC cis rs8133932 0.654 rs410902 chr21:47341794 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.85 -0.3 1.16e-8 Schizophrenia; LUSC cis rs7772486 0.875 rs932522 chr6:146374026 A/G cg13319975 chr6:146136371 FBXO30 0.47 6.75 0.35 6.41e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs701145 0.938 rs701135 chr3:154065455 C/G cg17054900 chr3:154042577 DHX36 0.79 8.25 0.41 3.74e-15 Coronary artery disease; LUSC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg06634786 chr22:41940651 POLR3H -0.56 -6.54 -0.34 2.29e-10 Vitiligo; LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.06 -0.36 9.55e-12 Bipolar disorder; LUSC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs6445797 0.632 rs4681951 chr3:56633402 A/G cg13792233 chr3:56591045 CCDC66 0.4 5.7 0.3 2.67e-8 Gastritis; LUSC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.77e-16 Aortic root size; LUSC cis rs7119 0.604 rs939488 chr15:77867780 T/C cg27398640 chr15:77910606 LINGO1 0.35 7.78 0.39 9.23e-14 Type 2 diabetes; LUSC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg11608241 chr8:8085544 FLJ10661 -0.45 -6.19 -0.32 1.81e-9 Schizophrenia; LUSC cis rs6977660 0.714 rs2390157 chr7:19786177 G/A cg05791153 chr7:19748676 TWISTNB 0.75 7.42 0.38 1.01e-12 Thyroid stimulating hormone; LUSC cis rs859767 0.812 rs842360 chr2:135347885 T/C cg12500956 chr2:135428796 TMEM163 0.25 5.75 0.3 2.02e-8 Neuroticism; LUSC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg24209194 chr3:40518798 ZNF619 0.56 6.75 0.35 6.72e-11 Renal cell carcinoma; LUSC trans rs7094131 0.542 rs7071306 chr10:22867339 A/G cg06317507 chr6:134159179 MGC34034 0.42 6.27 0.32 1.11e-9 Obesity-related traits; LUSC cis rs12135894 0.648 rs4648423 chr1:3765678 C/T cg13057898 chr1:3703894 LRRC47 -0.35 -6.51 -0.34 2.72e-10 Mean corpuscular volume; LUSC trans rs1728785 0.901 rs1170437 chr16:68607943 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.94 0.4 3.18e-14 Ulcerative colitis; LUSC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 6.61 0.34 1.56e-10 Personality dimensions; LUSC cis rs208520 0.909 rs62414636 chr6:67015723 T/G cg07460842 chr6:66804631 NA 0.88 8.93 0.44 2.87e-17 Exhaled nitric oxide output; LUSC cis rs478607 0.831 rs61884374 chr11:64388929 A/G cg19131476 chr11:64387923 NRXN2 0.34 5.92 0.31 7.81e-9 Urate levels; LUSC cis rs9902453 0.933 rs4470197 chr17:28464474 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.87 0.4 4.86e-14 Coffee consumption (cups per day); LUSC cis rs3820068 0.608 rs2057304 chr1:16017710 A/G cg13390004 chr1:15929781 NA 0.42 6.82 0.35 4.38e-11 Systolic blood pressure; LUSC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg04369109 chr6:150039330 LATS1 -0.52 -7.53 -0.38 4.91e-13 Lung cancer; LUSC cis rs10876993 0.890 rs774887 chr12:58034835 A/G cg15848620 chr12:58087721 OS9 -0.5 -7.04 -0.36 1.08e-11 Celiac disease or Rheumatoid arthritis; LUSC cis rs459571 0.959 rs2520100 chr9:136918137 A/T cg01294253 chr9:136912663 BRD3 0.34 5.92 0.31 8.12e-9 Platelet distribution width; LUSC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg00745463 chr17:30367425 LRRC37B -0.76 -8.58 -0.42 3.68e-16 Hip circumference adjusted for BMI; LUSC cis rs2439831 0.850 rs3736180 chr15:44106624 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.93 9.16 0.45 5.22e-18 Lung cancer in ever smokers; LUSC cis rs6546537 0.503 rs7576953 chr2:69911916 C/T cg10773587 chr2:69614142 GFPT1 0.41 6.17 0.32 1.96e-9 Serum thyroid-stimulating hormone levels; LUSC cis rs68170813 0.523 rs3757713 chr7:107042750 A/C cg02696742 chr7:106810147 HBP1 -0.65 -9.28 -0.45 2.28e-18 Coronary artery disease; LUSC cis rs7582180 0.614 rs1030901 chr2:101007314 G/A cg12002119 chr2:101014098 CHST10 0.38 6.38 0.33 6e-10 Intelligence (multi-trait analysis); LUSC cis rs4654899 0.965 rs7512116 chr1:21501095 C/A cg01072550 chr1:21505969 NA -0.55 -8.49 -0.42 7e-16 Superior frontal gyrus grey matter volume; LUSC cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.74 -0.3 2.1e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs5167 0.566 rs2075618 chr19:45495668 G/C cg25746394 chr19:45450501 APOC2 0.32 6.07 0.32 3.55e-9 Blood protein levels; LUSC cis rs8017423 1.000 rs8011810 chr14:90685669 A/G cg04374321 chr14:90722782 PSMC1 0.7 11.12 0.52 1.19e-24 Mortality in heart failure; LUSC trans rs7613875 0.620 rs7634441 chr3:50071677 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.81 -0.39 7.23e-14 Body mass index; LUSC cis rs4660306 1.000 rs10736426 chr1:45984353 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.41 6.51 0.34 2.76e-10 Homocysteine levels; LUSC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg18876405 chr7:65276391 NA 0.76 13.64 0.6 5.69e-34 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01813026 chr11:809279 RPLP2 -0.41 -6.1 -0.32 2.92e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg10523860 chr14:103875565 MARK3 -0.37 -5.92 -0.31 8.18e-9 Bone mineral density; LUSC cis rs7909074 1.000 rs4481983 chr10:45400428 G/T cg05187965 chr10:45406764 TMEM72 -0.37 -8.7 -0.43 1.55e-16 Mean corpuscular volume; LUSC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg06453172 chr10:134556979 INPP5A -0.49 -6.11 -0.32 2.78e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7312933 0.558 rs4768411 chr12:42855390 A/G cg01256987 chr12:42539512 GXYLT1 0.35 6.44 0.33 4.18e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs61931739 0.517 rs1197562 chr12:34122037 G/A cg13010199 chr12:38710504 ALG10B 0.52 7.86 0.4 5.4e-14 Morning vs. evening chronotype; LUSC cis rs189798 0.807 rs330909 chr8:8995387 A/G cg06636001 chr8:8085503 FLJ10661 0.5 6.79 0.35 5.13e-11 Myopia (pathological); LUSC cis rs6964587 1.000 rs4727267 chr7:91570290 G/C cg22117172 chr7:91764530 CYP51A1 -0.32 -5.82 -0.3 1.41e-8 Breast cancer; LUSC cis rs9796 0.870 rs3986311 chr15:41264339 C/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.92 -0.35 2.33e-11 Menopause (age at onset); LUSC cis rs8060686 0.545 rs117751972 chr16:68171968 C/T cg05110241 chr16:68378359 PRMT7 -0.64 -6.94 -0.36 1.99e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs701145 0.585 rs1713813 chr3:153873643 T/G cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.51 7.7 0.39 1.59e-13 Personality dimensions; LUSC cis rs9633740 1.000 rs6586028 chr10:82253984 C/T cg01528321 chr10:82214614 TSPAN14 1.08 12.1 0.55 3.35e-28 Post bronchodilator FEV1; LUSC cis rs12210905 0.925 rs4541737 chr6:27002821 C/T cg23155468 chr6:27110703 HIST1H2BK -0.69 -6.01 -0.31 4.99e-9 Hip circumference adjusted for BMI; LUSC cis rs853679 0.546 rs483143 chr6:27846744 G/C cg26587870 chr6:27730563 NA -0.62 -5.79 -0.3 1.61e-8 Depression; LUSC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg02423579 chr7:2872169 GNA12 -0.37 -5.64 -0.3 3.55e-8 Height; LUSC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg25025879 chr12:53359317 NA -0.44 -6.81 -0.35 4.62e-11 Prostate cancer; LUSC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg11752832 chr7:134001865 SLC35B4 0.56 8.8 0.43 7.57e-17 Mean platelet volume; LUSC cis rs3806843 1.000 rs3756339 chr5:140180537 A/G cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.37e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs925255 0.774 rs7562 chr2:28635740 T/C cg01273330 chr2:28605224 NA 0.4 6.32 0.33 8.25e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1322512 0.917 rs73009163 chr6:153002192 G/A cg27316956 chr6:152958899 SYNE1 0.37 6.23 0.32 1.4e-9 Tonometry; LUSC cis rs7809950 1.000 rs2520269 chr7:107191327 T/C cg23024343 chr7:107201750 COG5 -0.57 -9.01 -0.44 1.62e-17 Coronary artery disease; LUSC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.74 0.35 6.99e-11 Intelligence (multi-trait analysis); LUSC cis rs243505 0.595 rs10233740 chr7:148567263 C/T cg09806900 chr7:148480153 CUL1 0.43 5.67 0.3 3.08e-8 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9309473 0.528 rs11126395 chr2:73564964 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -6.96 -0.36 1.79e-11 Metabolite levels; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg18758796 chr5:131593413 PDLIM4 0.41 6.75 0.35 6.69e-11 Breast cancer; LUSC cis rs9400467 0.528 rs11153280 chr6:111589293 A/C cg22127309 chr6:111907043 TRAF3IP2 -0.35 -6.39 -0.33 5.72e-10 Blood metabolite levels;Amino acid levels; LUSC trans rs7951105 1.000 rs11035155 chr11:39248248 C/T cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg06713675 chr4:122721982 EXOSC9 -0.47 -8.23 -0.41 4.19e-15 Type 2 diabetes; LUSC cis rs62408225 0.925 rs6925032 chr6:91008027 C/A cg06866423 chr6:90926672 BACH2 0.43 6.17 0.32 1.98e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.86 -0.44 4.83e-17 Monocyte percentage of white cells; LUSC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg15557168 chr22:42548783 NA -0.47 -7.33 -0.37 1.76e-12 Schizophrenia; LUSC cis rs1478897 0.575 rs12679960 chr8:11430990 C/T cg21775007 chr8:11205619 TDH 0.43 5.94 0.31 7.31e-9 Systemic lupus erythematosus; LUSC cis rs11662586 0.517 rs11663082 chr18:77713494 C/T cg20368463 chr18:77673604 PQLC1 0.76 12.74 0.57 1.46e-30 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.79 0.35 5.21e-11 Tonsillectomy; LUSC cis rs9457247 0.602 rs9457262 chr6:167473685 A/G cg07741184 chr6:167504864 NA 0.49 8.55 0.42 4.6e-16 Crohn's disease; LUSC cis rs8092503 0.951 rs1833281 chr18:52498801 C/G cg12377874 chr18:52495404 RAB27B 0.34 5.94 0.31 7.14e-9 Childhood body mass index; LUSC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2806561 0.765 rs668234 chr1:23515467 G/A cg12483005 chr1:23474871 LUZP1 0.41 6.5 0.33 2.98e-10 Height; LUSC trans rs11722228 0.549 rs55848383 chr4:10081117 C/A cg26043149 chr18:55253948 FECH 0.96 14.36 0.62 9.24e-37 Gout;Urate levels;Serum uric acid levels; LUSC cis rs11971779 0.553 rs10269108 chr7:139106332 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6867032 0.917 rs10474733 chr5:2004160 A/G cg26168224 chr5:2018326 NA -0.76 -13.48 -0.59 2.21e-33 Gut microbiome composition (winter); LUSC cis rs11758351 1.000 rs112751982 chr6:26191958 C/T cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg03264133 chr6:25882463 NA 0.38 6.26 0.32 1.15e-9 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10959786 chr13:74708124 KLF12 0.41 5.98 0.31 5.75e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs2055729 0.677 rs59880252 chr8:9741032 C/T cg06636001 chr8:8085503 FLJ10661 0.49 6.04 0.31 4.17e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs7681440 0.904 rs1442153 chr4:90775719 T/G cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.96 -0.31 6.49e-9 Dementia with Lewy bodies; LUSC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg24642844 chr7:1081250 C7orf50 -0.7 -9.7 -0.47 9.03e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs3733585 0.683 rs6449140 chr4:9936437 G/C cg26043149 chr18:55253948 FECH -0.47 -7.23 -0.37 3.28e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.38 -0.37 1.23e-12 Psoriasis; LUSC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs931127 0.658 rs12787843 chr11:65477306 A/C cg05805236 chr11:65401703 PCNXL3 -0.45 -7.61 -0.38 2.89e-13 Systemic lupus erythematosus; LUSC cis rs354225 0.584 rs10206143 chr2:54817453 A/T cg26097391 chr2:54893211 SPTBN1 0.43 6.5 0.33 2.96e-10 Schizophrenia; LUSC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg06481639 chr22:41940642 POLR3H 0.5 5.77 0.3 1.81e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg04352962 chr1:209979756 IRF6 0.54 6.28 0.33 1.03e-9 Cleft lip with or without cleft palate; LUSC trans rs1941687 0.797 rs6507070 chr18:31393244 C/A cg27147174 chr7:100797783 AP1S1 -0.44 -6.45 -0.33 3.83e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs12188164 0.932 rs2230437 chr5:476353 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -8.15 -0.41 7.26e-15 Cystic fibrosis severity; LUSC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg22875332 chr1:76189707 ACADM 0.83 14.07 0.61 1.27e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.95 0.31 6.7e-9 Menopause (age at onset); LUSC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg19052272 chr2:3704530 ALLC -0.35 -6.97 -0.36 1.68e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg02423579 chr7:2872169 GNA12 -0.48 -6.73 -0.35 7.45e-11 Height; LUSC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs4499344 0.504 rs259248 chr19:33148041 T/C cg22980127 chr19:33182716 NUDT19 -0.43 -6.39 -0.33 5.7e-10 Mean platelet volume; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg26516362 chr5:178986906 RUFY1 0.55 10.09 0.48 4.57e-21 Lung cancer; LUSC cis rs3768617 0.510 rs10797851 chr1:183098001 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC trans rs7746199 0.736 rs13193480 chr6:27702561 A/G cg06606381 chr12:133084897 FBRSL1 -0.94 -8.79 -0.43 8.32e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg23283495 chr1:209979779 IRF6 0.67 7.56 0.38 4e-13 Coronary artery disease; LUSC cis rs9595066 0.941 rs9533777 chr13:44708720 C/T cg04068111 chr13:44716778 NA 0.53 7.42 0.38 9.89e-13 Schizophrenia; LUSC cis rs7106204 0.534 rs75335266 chr11:24256395 G/T ch.11.24196551F chr11:24239977 NA 0.75 6.39 0.33 5.58e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg04287289 chr16:89883240 FANCA 0.76 6.26 0.32 1.19e-9 Skin colour saturation; LUSC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg09491104 chr22:46646882 C22orf40 -0.63 -7.19 -0.37 4.35e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs753778 0.667 rs6578153 chr8:142209543 C/T cg18755752 chr8:142205143 DENND3 -0.71 -12.52 -0.57 9.79e-30 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg18352616 chr4:3374830 RGS12 0.32 6.31 0.33 8.72e-10 Serum sulfate level; LUSC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg00677455 chr12:58241039 CTDSP2 0.59 8.48 0.42 7.35e-16 Multiple sclerosis; LUSC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg18302933 chr2:88491318 NA -0.38 -7.47 -0.38 7.04e-13 Response to metformin (IC50); LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 13.96 0.61 3.25e-35 Platelet count; LUSC cis rs9420 0.961 rs79260745 chr11:57612960 T/C cg23127183 chr11:57508653 C11orf31 -0.56 -8.45 -0.42 9.27e-16 Schizophrenia; LUSC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.37 0.42 1.63e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs6500602 0.727 rs2058811 chr16:4575162 C/T cg08645402 chr16:4508243 NA 0.52 8.75 0.43 1.1e-16 Schizophrenia; LUSC cis rs12681288 0.640 rs6985741 chr8:962858 C/T cg15309053 chr8:964076 NA 0.36 6.82 0.35 4.35e-11 Schizophrenia; LUSC cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg24642439 chr20:33292090 TP53INP2 0.47 7.18 0.37 4.46e-12 Glomerular filtration rate (creatinine); LUSC cis rs72781680 0.898 rs72782117 chr2:24026921 G/A cg08917208 chr2:24149416 ATAD2B 0.96 9.92 0.48 1.69e-20 Lymphocyte counts; LUSC cis rs16854884 0.526 rs7643341 chr3:143726980 C/T cg06585982 chr3:143692056 C3orf58 0.41 6.54 0.34 2.31e-10 Economic and political preferences (feminism/equality); LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg07092213 chr7:1199455 ZFAND2A -0.4 -6.04 -0.31 4.13e-9 Longevity;Endometriosis; LUSC cis rs2607426 0.681 rs2607418 chr19:41257396 A/G cg05508168 chr19:41255947 C19orf54;SNRPA -0.88 -6.86 -0.35 3.38e-11 Blood protein levels; LUSC cis rs7267979 0.744 rs6050463 chr20:25208990 G/A cg08601574 chr20:25228251 PYGB 0.55 8.84 0.44 5.66e-17 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg06017677 chr12:123236875 DENR -0.6 -6.42 -0.33 4.79e-10 Schizophrenia; LUSC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg26587870 chr6:27730563 NA -0.46 -5.8 -0.3 1.54e-8 Breast cancer; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg02478158 chr15:67073907 SMAD6 -0.44 -6.8 -0.35 4.94e-11 N-glycan levels; LUSC trans rs7613875 0.620 rs13079006 chr3:49996924 G/T cg21659725 chr3:3221576 CRBN 0.54 8.76 0.43 9.82e-17 Body mass index; LUSC trans rs877282 0.947 rs12358875 chr10:757531 T/C cg13042288 chr15:90349979 ANPEP -0.47 -6.51 -0.34 2.71e-10 Uric acid levels; LUSC cis rs10504073 0.626 rs6472220 chr8:50008477 C/A cg00325661 chr8:49890786 NA 0.63 10.58 0.5 9.35e-23 Blood metabolite ratios; LUSC cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg23649088 chr2:200775458 C2orf69 -0.56 -6.69 -0.34 9.43e-11 Schizophrenia; LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg06671660 chr6:41068741 NFYA;LOC221442 -0.39 -5.67 -0.3 3.07e-8 Alzheimer's disease (late onset); LUSC trans rs4332037 1.000 rs10240470 chr7:1949971 G/T cg10840412 chr1:235813424 GNG4 -0.65 -8.72 -0.43 1.29e-16 Bipolar disorder; LUSC cis rs1577917 0.958 rs12215232 chr6:86785430 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.37 -0.42 1.59e-15 Response to antipsychotic treatment; LUSC cis rs12711979 0.765 rs13028529 chr2:3825467 C/T cg17052675 chr2:3827356 NA -0.57 -11.18 -0.52 7.02e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs8028313 0.630 rs12900208 chr15:67963058 C/G cg08079166 chr15:68083412 MAP2K5 0.37 6.18 0.32 1.82e-9 Obesity; LUSC trans rs7647973 0.626 rs9830730 chr3:49675875 G/C cg21659725 chr3:3221576 CRBN -0.68 -7.95 -0.4 2.97e-14 Menarche (age at onset); LUSC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg22823121 chr1:150693482 HORMAD1 0.51 7.39 0.38 1.15e-12 Melanoma; LUSC cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg24562669 chr7:97807699 LMTK2 -0.4 -7.1 -0.36 7.6e-12 Breast cancer; LUSC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg12292205 chr6:26970375 C6orf41 -0.7 -12.21 -0.56 1.3e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs7582180 0.676 rs11680660 chr2:100931738 G/C cg08017756 chr2:100939284 LONRF2 -0.44 -8.26 -0.41 3.39e-15 Intelligence (multi-trait analysis); LUSC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg06671706 chr8:8559999 CLDN23 0.48 6.58 0.34 1.86e-10 Obesity-related traits; LUSC cis rs10761482 0.906 rs10740023 chr10:62088266 T/C cg18175470 chr10:62150864 ANK3 -0.49 -6.72 -0.34 8.1e-11 Schizophrenia; LUSC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.62e-9 Aortic root size; LUSC cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.76e-11 Intelligence (multi-trait analysis); LUSC cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg08807101 chr21:30365312 RNF160 0.79 14.92 0.63 6.3e-39 Dental caries; LUSC cis rs8017423 0.900 rs11625870 chr14:90693396 C/T cg04374321 chr14:90722782 PSMC1 -0.69 -10.43 -0.5 3.01e-22 Mortality in heart failure; LUSC cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.99 0.31 5.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.16 0.32 2.1e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg04369109 chr6:150039330 LATS1 -0.52 -7.34 -0.37 1.65e-12 Lung cancer; LUSC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg09021430 chr5:549028 NA -0.57 -7.7 -0.39 1.61e-13 Obesity-related traits; LUSC cis rs910316 0.763 rs175047 chr14:75479039 C/G cg08847533 chr14:75593920 NEK9 -0.81 -13.91 -0.61 5.04e-35 Height; LUSC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg16680214 chr1:154839983 KCNN3 -0.51 -9.28 -0.45 2.25e-18 Prostate cancer; LUSC cis rs9341808 0.718 rs9359408 chr6:80820132 T/G cg08355045 chr6:80787529 NA 0.56 9.59 0.46 2.06e-19 Sitting height ratio; LUSC cis rs672059 1.000 rs660602 chr1:183162774 T/G ch.1.3577855R chr1:183094577 LAMC1 0.55 8.1 0.41 1.02e-14 Hypertriglyceridemia; LUSC cis rs2204008 0.580 rs1315373 chr12:38179114 T/G cg13010199 chr12:38710504 ALG10B -0.52 -7.91 -0.4 3.93e-14 Bladder cancer; LUSC cis rs7903847 0.667 rs10882931 chr10:99165794 C/A cg20016023 chr10:99160130 RRP12 -0.3 -7.44 -0.38 8.68e-13 Granulocyte percentage of myeloid white cells; LUSC trans rs11250098 0.541 rs6997839 chr8:10766028 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -6.91 -0.35 2.51e-11 Morning vs. evening chronotype; LUSC cis rs9788721 0.933 rs72738786 chr15:78828086 G/T cg18825076 chr15:78729989 IREB2 -0.52 -8.21 -0.41 4.99e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg26587870 chr6:27730563 NA -0.61 -5.67 -0.3 3.14e-8 Depression; LUSC cis rs2742234 0.541 rs10899779 chr10:43723976 C/T cg02780029 chr10:43622663 RET 0.35 5.76 0.3 1.94e-8 Hirschsprung disease; LUSC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.87 0.35 3.09e-11 Parkinson's disease; LUSC trans rs7156960 1.000 rs7156960 chr14:76703351 C/G cg22433775 chr8:67976671 CSPP1 0.38 6.02 0.31 4.57e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg06028605 chr16:24865363 SLC5A11 -0.68 -10.86 -0.51 9.61e-24 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.602 rs1790098 chr12:123655481 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.33 -0.33 7.98e-10 Neutrophil percentage of white cells; LUSC cis rs701145 0.878 rs355760 chr3:154009933 T/C cg17054900 chr3:154042577 DHX36 0.84 8.56 0.42 4.29e-16 Coronary artery disease; LUSC cis rs6690583 0.623 rs1371142 chr1:85455373 A/T cg11262906 chr1:85462892 MCOLN2 0.67 6.53 0.34 2.51e-10 Serum sulfate level; LUSC cis rs738322 0.870 rs2277844 chr22:38577515 G/A cg17652424 chr22:38574118 PLA2G6 0.28 5.97 0.31 5.93e-9 Cutaneous nevi; LUSC cis rs9322817 0.691 rs4591886 chr6:105249970 G/C cg02098413 chr6:105308735 HACE1 -0.28 -5.8 -0.3 1.55e-8 Thyroid stimulating hormone; LUSC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.13 -0.48 3.34e-21 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg24675056 chr1:15929824 NA 0.42 7.15 0.36 5.37e-12 Systolic blood pressure; LUSC cis rs7772486 0.727 rs10223508 chr6:146285205 C/T cg23711669 chr6:146136114 FBXO30 -0.89 -16.82 -0.68 2.1e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.71 0.34 8.14e-11 Lung cancer; LUSC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg24110177 chr3:50126178 RBM5 0.58 9.72 0.47 8.04e-20 Intelligence (multi-trait analysis); LUSC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg26677194 chr12:130822605 PIWIL1 -0.59 -8.79 -0.43 7.9e-17 Menopause (age at onset); LUSC cis rs4731207 0.967 rs2299902 chr7:124397814 G/T cg14311320 chr7:124405732 GPR37 0.31 6.01 0.31 4.96e-9 Cutaneous malignant melanoma; LUSC cis rs2274273 0.588 rs17128145 chr14:55536406 G/T cg04306507 chr14:55594613 LGALS3 -0.43 -8.79 -0.43 7.91e-17 Protein biomarker; LUSC trans rs877282 1.000 rs11253362 chr10:770979 G/T cg13042288 chr15:90349979 ANPEP -0.47 -6.84 -0.35 3.78e-11 Uric acid levels; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 6.46 0.33 3.73e-10 Electroencephalogram traits; LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.05 0.55 5e-28 Prudent dietary pattern; LUSC cis rs9888739 0.844 rs41476751 chr16:31335906 T/C cg15817542 chr16:31343056 ITGAM -0.44 -6.08 -0.32 3.27e-9 Systemic lupus erythematosus; LUSC cis rs926938 0.527 rs1391484 chr1:115522366 A/G cg01522456 chr1:115632236 TSPAN2 -0.41 -6.41 -0.33 5.05e-10 Autism; LUSC cis rs859767 0.741 rs2176341 chr2:135371421 A/G cg12500956 chr2:135428796 TMEM163 -0.28 -6.23 -0.32 1.42e-9 Neuroticism; LUSC cis rs3785574 0.536 rs2854190 chr17:61960219 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 8.4 0.42 1.31e-15 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02032696 chr14:67982198 TMEM229B -0.41 -6.01 -0.31 4.77e-9 Electrocardiographic conduction measures; LUSC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg11861562 chr11:117069780 TAGLN 0.45 7.57 0.38 3.7e-13 Blood protein levels; LUSC cis rs500891 0.645 rs13196054 chr6:84174943 C/T cg08257003 chr6:84140564 ME1 -0.31 -7.09 -0.36 8.24e-12 Platelet-derived growth factor BB levels; LUSC cis rs6546537 0.550 rs4852272 chr2:69776730 C/T cg10773587 chr2:69614142 GFPT1 -0.43 -6.83 -0.35 3.98e-11 Serum thyroid-stimulating hormone levels; LUSC cis rs2200578 1.000 rs2200578 chr2:99876244 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.53 6.19 0.32 1.72e-9 IgG glycosylation; LUSC cis rs17270561 0.636 rs6923839 chr6:25745853 G/A cg17691542 chr6:26056736 HIST1H1C 0.58 8.12 0.41 8.87e-15 Iron status biomarkers; LUSC trans rs11098499 0.863 rs7678400 chr4:120461957 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.67 0.34 1.03e-10 Corneal astigmatism; LUSC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg23205692 chr1:25664452 TMEM50A 0.46 7.06 0.36 9.74e-12 Erythrocyte sedimentation rate; LUSC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.82 0.51 1.4e-23 Menopause (age at onset); LUSC trans rs2018683 0.523 rs4513881 chr7:29025410 C/T cg19402173 chr7:128379420 CALU 0.47 7.04 0.36 1.08e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg18876405 chr7:65276391 NA 0.55 8.59 0.43 3.48e-16 Aortic root size; LUSC cis rs11190604 1.000 rs10883492 chr10:102206089 G/A cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg17644776 chr2:200775616 C2orf69 -0.54 -9.61 -0.47 1.83e-19 Osteoporosis; LUSC cis rs10761482 0.861 rs7097138 chr10:62106755 G/T cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC trans rs61931739 1.000 rs12311881 chr12:34036100 A/G cg26384229 chr12:38710491 ALG10B -0.51 -7.78 -0.39 8.95e-14 Morning vs. evening chronotype; LUSC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.68 9.61 0.47 1.77e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs35771425 0.536 rs6656860 chr1:211620805 A/G cg25617285 chr1:211431773 RCOR3 -0.36 -5.87 -0.31 1.06e-8 Educational attainment (years of education); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13535478 chr19:15490918 AKAP8;AKAP8L -0.4 -6.24 -0.32 1.32e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs208520 0.909 rs55813840 chr6:67012508 A/C cg07460842 chr6:66804631 NA 0.88 8.93 0.44 2.87e-17 Exhaled nitric oxide output; LUSC cis rs9807989 0.801 rs7558339 chr2:102970243 T/G cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs7927592 0.913 rs67605986 chr11:68300955 C/T cg20283391 chr11:68216788 NA -0.61 -8.56 -0.42 4.03e-16 Total body bone mineral density; LUSC cis rs9326248 0.861 rs11216172 chr11:116749878 G/A cg11861562 chr11:117069780 TAGLN 0.39 6.69 0.34 9.33e-11 Blood protein levels; LUSC cis rs11626933 1.000 rs6575122 chr14:90753556 A/G cg14092571 chr14:90743983 NA -0.89 -18.83 -0.72 2.03e-54 Gut microbiota (bacterial taxa); LUSC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg12963246 chr6:28129442 ZNF389 0.53 7.3 0.37 2.16e-12 Depression; LUSC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg21285383 chr16:89894308 SPIRE2 0.33 7.05 0.36 1.05e-11 Vitiligo; LUSC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg05872129 chr22:39784769 NA -0.61 -11.61 -0.54 2.16e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg21984481 chr17:79567631 NPLOC4 -0.57 -10.89 -0.51 7.97e-24 Eye color traits; LUSC cis rs5758511 0.680 rs5758652 chr22:42612408 T/C cg00645731 chr22:42541494 CYP2D7P1 0.57 10.0 0.48 8.88e-21 Birth weight; LUSC cis rs3008870 0.755 rs2755242 chr1:67479598 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.3 0.56 5.99e-29 Lymphocyte percentage of white cells; LUSC trans rs7618501 0.602 rs2526754 chr3:50125996 G/A cg21659725 chr3:3221576 CRBN -0.64 -10.55 -0.5 1.17e-22 Intelligence (multi-trait analysis); LUSC cis rs1775715 0.870 rs11008702 chr10:32244818 T/G cg26784012 chr10:32216390 ARHGAP12 0.36 5.83 0.3 1.28e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4268898 0.636 rs72787385 chr2:24585820 G/A cg06627628 chr2:24431161 ITSN2 -0.87 -12.7 -0.57 2.07e-30 Asthma; LUSC cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC trans rs208515 0.556 rs10455193 chr6:66691456 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.27 0.62 2.12e-36 Exhaled nitric oxide levels; LUSC cis rs8044868 0.530 rs2287998 chr16:72059269 C/T cg16579770 chr16:72058938 DHODH -0.36 -5.98 -0.31 5.75e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.65 0.86 4.24e-99 Chronic sinus infection; LUSC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg05738196 chr6:26577821 NA 0.53 8.33 0.41 2.14e-15 Schizophrenia; LUSC cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg08499158 chr17:42289980 UBTF -0.56 -9.1 -0.45 8.62e-18 Total body bone mineral density; LUSC cis rs4561483 0.583 rs11647580 chr16:11957609 G/C cg08843971 chr16:11963173 GSPT1 0.42 6.4 0.33 5.29e-10 Testicular germ cell tumor; LUSC cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg11058730 chr11:34937778 PDHX;APIP 0.71 11.55 0.53 3.34e-26 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 19.77 0.73 3.92e-58 Prudent dietary pattern; LUSC trans rs11039798 0.588 rs11039855 chr11:48610091 A/G cg15704280 chr7:45808275 SEPT13 0.65 7.19 0.37 4.24e-12 Axial length; LUSC cis rs17401966 0.838 rs8019 chr1:10366487 T/G cg19773385 chr1:10388646 KIF1B -0.5 -8.63 -0.43 2.52e-16 Hepatocellular carcinoma; LUSC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg20203395 chr5:56204925 C5orf35 0.58 8.6 0.43 3.13e-16 Initial pursuit acceleration; LUSC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg17294928 chr15:75287854 SCAMP5 -0.93 -13.47 -0.59 2.47e-33 Blood trace element (Zn levels); LUSC trans rs2204008 0.805 rs11169513 chr12:37988640 G/A cg06521331 chr12:34319734 NA -0.41 -6.2 -0.32 1.71e-9 Bladder cancer; LUSC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg22433210 chr17:43662623 NA 0.76 10.84 0.51 1.17e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs78456975 0.943 rs13421238 chr2:1576879 G/A cg01028140 chr2:1542097 TPO -0.49 -6.94 -0.36 2e-11 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs72792276 1.000 rs3805603 chr5:127451581 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.89 7.51 0.38 5.36e-13 Red cell distribution width; LUSC cis rs7208859 0.573 rs73267872 chr17:29067207 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11971779 0.941 rs7800795 chr7:139080348 A/G cg07862535 chr7:139043722 LUC7L2 0.73 8.23 0.41 4.24e-15 Diisocyanate-induced asthma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14826516 chr22:50639351 SELO -0.39 -6.06 -0.31 3.76e-9 Electrocardiographic conduction measures; LUSC cis rs61931739 0.500 rs7489270 chr12:34432062 C/T cg06521331 chr12:34319734 NA -0.4 -6.26 -0.32 1.2e-9 Morning vs. evening chronotype; LUSC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg13319975 chr6:146136371 FBXO30 0.68 10.55 0.5 1.19e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg18240062 chr17:79603768 NPLOC4 -0.58 -10.12 -0.48 3.59e-21 Eye color traits; LUSC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg02574844 chr11:5959923 NA -0.41 -5.94 -0.31 7.25e-9 DNA methylation (variation); LUSC cis rs11997175 0.646 rs4733180 chr8:33700520 C/T ch.8.33884649F chr8:33765107 NA 0.45 6.7 0.34 8.67e-11 Body mass index; LUSC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg18230493 chr5:56204884 C5orf35 0.73 12.05 0.55 5.09e-28 Initial pursuit acceleration; LUSC cis rs7215564 0.908 rs34785514 chr17:78661166 A/G cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs1865721 1.000 rs17284077 chr18:73204128 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -8.1 -0.41 1.08e-14 Intelligence; LUSC cis rs6964587 1.000 rs417 chr7:91581121 C/A cg17063962 chr7:91808500 NA -0.56 -9.0 -0.44 1.74e-17 Breast cancer; LUSC cis rs7577696 0.785 rs7592239 chr2:32370258 C/A cg02381751 chr2:32503542 YIPF4 -0.42 -5.72 -0.3 2.36e-8 Inflammatory biomarkers; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg19509891 chr9:130662046 ST6GALNAC6 -0.5 -6.77 -0.35 5.92e-11 Hepatitis; LUSC cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg22676075 chr6:135203613 NA 0.57 9.04 0.44 1.26e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs34734847 0.787 rs7976497 chr12:121135467 T/C cg21892295 chr12:121157589 UNC119B -0.36 -6.29 -0.33 1.01e-9 Mean corpuscular volume; LUSC cis rs17102423 0.731 rs942629 chr14:65539318 A/G cg11161011 chr14:65562177 MAX -0.64 -9.91 -0.48 1.84e-20 Obesity-related traits; LUSC cis rs1552244 0.507 rs6443274 chr3:9995288 A/T cg16606324 chr3:10149918 C3orf24 0.43 6.82 0.35 4.22e-11 Alzheimer's disease; LUSC cis rs7937682 1.000 rs4936661 chr11:111587495 G/A cg09085632 chr11:111637200 PPP2R1B 1.14 17.27 0.69 3.35e-48 Primary sclerosing cholangitis; LUSC cis rs9283706 0.852 rs73103937 chr5:66280577 T/C cg11590213 chr5:66331682 MAST4 0.4 5.7 0.3 2.68e-8 Coronary artery disease; LUSC cis rs6076065 0.748 rs2236023 chr20:23373043 A/C cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.853 rs7133716 chr12:34041847 G/C cg13010199 chr12:38710504 ALG10B -0.4 -6.01 -0.31 4.99e-9 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.5 0.42 6.19e-16 Prudent dietary pattern; LUSC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg22875332 chr1:76189707 ACADM 0.76 10.17 0.49 2.4e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8077889 0.645 rs1230396 chr17:41843029 A/C cg26893861 chr17:41843967 DUSP3 -1.13 -25.31 -0.81 1.16e-79 Triglycerides; LUSC cis rs16912285 0.535 rs7936178 chr11:24252515 G/T ch.11.24196551F chr11:24239977 NA 0.92 10.2 0.49 1.98e-21 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9790314 1.000 rs336569 chr3:161072346 T/G cg04691961 chr3:161091175 C3orf57 -0.35 -6.14 -0.32 2.31e-9 Morning vs. evening chronotype; LUSC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs636291 0.510 rs1307487 chr1:10506667 G/A cg17425144 chr1:10567563 PEX14 0.55 10.36 0.49 5.25e-22 Prostate cancer; LUSC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg04518342 chr5:131593106 PDLIM4 -0.34 -6.23 -0.32 1.37e-9 Blood metabolite levels; LUSC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg10523679 chr1:76189770 ACADM 0.83 11.31 0.53 2.44e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1322512 0.917 rs1527367 chr6:152942517 A/T cg27316956 chr6:152958899 SYNE1 -0.35 -5.77 -0.3 1.77e-8 Tonometry; LUSC cis rs9300255 0.739 rs1969354 chr12:123741776 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.24 -0.32 1.35e-9 Neutrophil percentage of white cells; LUSC cis rs1215050 0.740 rs783963 chr4:98989070 A/G cg17366294 chr4:99064904 C4orf37 0.35 5.79 0.3 1.67e-8 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs561341 1.000 rs72821952 chr17:30248133 T/A cg27661571 chr11:113659931 NA -0.72 -7.76 -0.39 1.04e-13 Hip circumference adjusted for BMI; LUSC cis rs500891 0.525 rs1145895 chr6:84042326 C/A cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.08e-14 Platelet-derived growth factor BB levels; LUSC cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg13010199 chr12:38710504 ALG10B 0.69 11.65 0.54 1.5e-26 Heart rate; LUSC cis rs9788721 0.835 rs17487223 chr15:78923987 A/G cg06917634 chr15:78832804 PSMA4 0.44 6.13 0.32 2.54e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs16867321 0.950 rs2887180 chr2:181449305 C/A cg23363182 chr2:181467187 NA -0.44 -5.95 -0.31 6.78e-9 Obesity; LUSC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.69 0.54 1.11e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg06238570 chr21:40685208 BRWD1 0.47 7.25 0.37 2.84e-12 Cognitive function; LUSC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.31 0.49 8.09e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.53 -7.53 -0.38 4.85e-13 Renal function-related traits (BUN); LUSC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg12756686 chr19:29218302 NA 0.58 6.81 0.35 4.47e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg21535247 chr6:8435926 SLC35B3 0.58 9.0 0.44 1.75e-17 Motion sickness; LUSC cis rs3741151 0.881 rs79623427 chr11:73094896 C/T cg17517138 chr11:73019481 ARHGEF17 1.07 8.84 0.44 5.58e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1957429 0.520 rs72625642 chr14:65338884 G/T cg23373153 chr14:65346875 NA -0.87 -7.56 -0.38 4.04e-13 Pediatric areal bone mineral density (radius); LUSC cis rs17826219 0.706 rs2322197 chr17:29105805 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.77 0.35 5.93e-11 Body mass index; LUSC cis rs72960926 0.744 rs55962148 chr6:74962021 G/T cg03266952 chr6:74778945 NA -0.85 -7.14 -0.36 5.86e-12 Metabolite levels (MHPG); LUSC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg23590916 chr17:43697445 MGC57346 -0.48 -6.5 -0.34 2.93e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6918586 0.636 rs198857 chr6:26102417 G/C cg17691542 chr6:26056736 HIST1H1C 0.4 5.92 0.31 8.02e-9 Schizophrenia; LUSC cis rs62408225 1.000 rs62408235 chr6:90978383 T/C cg06866423 chr6:90926672 BACH2 0.42 5.99 0.31 5.36e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7954584 0.635 rs7137218 chr12:122342877 G/T cg21171335 chr12:122356390 WDR66 0.58 8.8 0.43 7.35e-17 Mean corpuscular volume; LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg25767906 chr1:53392781 SCP2 -0.51 -9.21 -0.45 3.7e-18 Monocyte count; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04824390 chr6:13710980 RANBP9 0.4 6.01 0.31 4.79e-9 Triglycerides; LUSC trans rs11098499 0.913 rs13126596 chr4:120140729 A/G cg25214090 chr10:38739885 LOC399744 0.46 6.72 0.35 7.96e-11 Corneal astigmatism; LUSC cis rs10779751 0.734 rs2791649 chr1:11132561 A/G cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs314370 0.951 rs3757868 chr7:100482720 G/A cg08558340 chr7:100472263 SRRT 0.5 6.23 0.32 1.37e-9 Resting heart rate; LUSC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg03929089 chr4:120376271 NA -0.98 -16.38 -0.67 1.14e-44 Coronary artery disease; LUSC cis rs12579753 0.917 rs12822036 chr12:82183009 C/T cg07988820 chr12:82153109 PPFIA2 -0.4 -5.66 -0.3 3.26e-8 Resting heart rate; LUSC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -6.24 -0.32 1.31e-9 Self-reported allergy; LUSC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg13939156 chr17:80058883 NA -0.33 -6.46 -0.33 3.6e-10 Life satisfaction; LUSC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.61 -9.34 -0.46 1.4e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10416265 0.528 rs17884930 chr19:33595390 A/G cg17764715 chr19:33622953 WDR88 0.57 6.16 0.32 2.1e-9 Bone properties (heel); LUSC cis rs9527 0.590 rs10883818 chr10:104759586 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.63 0.47 1.54e-19 Arsenic metabolism; LUSC cis rs11098499 0.954 rs12508504 chr4:120410607 A/C cg24375607 chr4:120327624 NA 0.77 11.8 0.54 4.1e-27 Corneal astigmatism; LUSC cis rs8179 0.553 rs42038 chr7:92243719 A/G cg15732164 chr7:92237376 CDK6 0.41 6.33 0.33 7.97e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs950776 0.616 rs495090 chr15:78870003 A/G cg06917634 chr15:78832804 PSMA4 -0.68 -10.99 -0.52 3.42e-24 Sudden cardiac arrest; LUSC cis rs2286503 0.780 rs929464 chr7:22874770 T/C cg11367502 chr7:22862612 TOMM7 0.49 6.33 0.33 7.92e-10 Fibrinogen; LUSC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.04 -0.31 4.17e-9 Developmental language disorder (linguistic errors); LUSC trans rs804280 0.509 rs35626932 chr8:11786932 C/A cg08975724 chr8:8085496 FLJ10661 0.49 7.26 0.37 2.71e-12 Myopia (pathological); LUSC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg17328964 chr8:145687451 CYHR1 0.71 11.64 0.54 1.59e-26 Age at first birth; LUSC cis rs8141529 0.764 rs5752807 chr22:29223169 A/G cg15103426 chr22:29168792 CCDC117 0.6 8.35 0.42 1.89e-15 Lymphocyte counts; LUSC cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg08999081 chr20:33150536 PIGU 0.44 8.03 0.4 1.73e-14 Coronary artery disease; LUSC cis rs7216064 1.000 rs56393562 chr17:65933918 C/T cg12091567 chr17:66097778 LOC651250 -0.71 -9.12 -0.45 7.15e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs4843747 0.697 rs72818533 chr16:88073841 G/A cg26811252 chr16:29126840 RRN3P2 0.64 10.32 0.49 7.6e-22 Menopause (age at onset); LUSC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg06022373 chr22:39101656 GTPBP1 0.75 11.92 0.55 1.55e-27 Menopause (age at onset); LUSC cis rs6674970 1.000 rs7546304 chr1:151114484 C/G cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.45 -6.14 -0.32 2.39e-9 Childhood ear infection; LUSC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.86 0.31 1.13e-8 Tonsillectomy; LUSC cis rs60012524 1 rs60012524 chr2:99559117 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.88 -11.25 -0.52 4.16e-25 Chronic sinus infection; LUSC cis rs2832077 0.689 rs2832055 chr21:30132382 C/G cg08807101 chr21:30365312 RNF160 0.53 7.11 0.36 7.24e-12 Cognitive test performance; LUSC cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC cis rs73001065 0.901 rs73002956 chr19:19578743 A/G cg03709012 chr19:19516395 GATAD2A 0.95 7.2 0.37 4.02e-12 LDL cholesterol; LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.18 0.37 4.69e-12 Platelet count; LUSC cis rs9790314 0.967 rs339101 chr3:161064193 A/T cg03342759 chr3:160939853 NMD3 -0.48 -7.94 -0.4 3.05e-14 Morning vs. evening chronotype; LUSC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg18135555 chr8:22132992 PIWIL2 0.39 7.71 0.39 1.5e-13 Hypertriglyceridemia; LUSC cis rs2742234 0.541 rs1059484 chr10:43679800 T/G cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs7188861 0.768 rs1794025 chr16:11380945 C/T cg00044050 chr16:11439710 C16orf75 0.56 6.31 0.33 8.71e-10 HDL cholesterol; LUSC cis rs12048904 1.000 rs12048904 chr1:101331536 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.51 -8.09 -0.4 1.09e-14 Multiple sclerosis; LUSC cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg15423357 chr2:25149977 NA 0.46 9.1 0.45 8.34e-18 Body mass index; LUSC cis rs4423214 1.000 rs4944957 chr11:71168035 C/T cg05163923 chr11:71159392 DHCR7 -0.72 -10.52 -0.5 1.49e-22 Vitamin D levels; LUSC cis rs13031619 0.607 rs13001751 chr2:3695870 A/G cg10645314 chr2:3704589 ALLC -0.38 -6.66 -0.34 1.11e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg01879757 chr17:41196368 BRCA1 -0.48 -7.4 -0.38 1.12e-12 Menopause (age at onset); LUSC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg18876405 chr7:65276391 NA 0.6 9.72 0.47 7.63e-20 Aortic root size; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg14159672 chr1:205819179 PM20D1 0.54 8.81 0.43 6.8e-17 Menarche (age at onset); LUSC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.23 0.52 4.91e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs662064 0.962 rs1188525 chr1:10550877 A/G cg20482658 chr1:10539492 PEX14 -0.34 -6.9 -0.35 2.69e-11 Asthma; LUSC cis rs7147624 1.000 rs2411821 chr14:65896914 G/T cg03016385 chr14:66212404 NA -0.78 -9.08 -0.44 9.59e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7572733 0.534 rs696817 chr2:198722225 A/G cg00792783 chr2:198669748 PLCL1 0.43 5.86 0.31 1.12e-8 Dermatomyositis; LUSC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg09491104 chr22:46646882 C22orf40 -0.69 -8.91 -0.44 3.46e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.18 0.37 4.48e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7264396 0.690 rs2425164 chr20:34434916 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.63 -0.43 2.49e-16 Total cholesterol levels; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg27233612 chr3:25824257 NGLY1 0.44 6.29 0.33 9.88e-10 Cognitive function;Information processing speed; LUSC cis rs9467773 1.000 rs1535277 chr6:26567802 G/T cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs1348850 0.793 rs6736390 chr2:178480314 T/C cg22681709 chr2:178499509 PDE11A -0.56 -10.49 -0.5 2e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1215050 0.755 rs783958 chr4:98893836 A/T cg05340658 chr4:99064831 C4orf37 -0.43 -6.84 -0.35 3.9e-11 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13170934 chr1:156722147 HDGF -0.4 -5.94 -0.31 7.06e-9 Hepatitis; LUSC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg23093090 chr10:104574429 C10orf26 0.46 8.63 0.43 2.46e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7582720 0.943 rs72932583 chr2:203869847 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.76 8.22 0.41 4.56e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9300255 0.602 rs1106240 chr12:123626982 C/T cg00376283 chr12:123451042 ABCB9 0.66 7.48 0.38 6.76e-13 Neutrophil percentage of white cells; LUSC cis rs7131987 0.903 rs11050161 chr12:29420049 A/G cg09582351 chr12:29534625 ERGIC2 -0.32 -6.66 -0.34 1.12e-10 QT interval; LUSC cis rs6681460 0.649 rs1415984 chr1:67002117 A/G cg02459107 chr1:67143332 SGIP1 0.38 6.07 0.32 3.48e-9 Presence of antiphospholipid antibodies; LUSC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg04287289 chr16:89883240 FANCA 0.78 6.24 0.32 1.29e-9 Skin colour saturation; LUSC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg05084668 chr3:125655381 ALG1L -0.48 -6.79 -0.35 5.06e-11 Blood pressure (smoking interaction); LUSC cis rs921665 1.000 rs7581068 chr2:3178831 T/C cg02624386 chr2:3182749 NA 0.52 6.06 0.31 3.72e-9 World class endurance athleticism; LUSC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg08680598 chr22:49984980 NA -0.34 -6.36 -0.33 6.69e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7106204 0.609 rs12804374 chr11:24338016 A/G ch.11.24196551F chr11:24239977 NA 0.71 5.92 0.31 7.99e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.77 -12.46 -0.56 1.54e-29 Chronic sinus infection; LUSC cis rs67981189 0.634 rs221898 chr14:71605516 A/G cg15816911 chr14:71606274 NA 0.35 6.28 0.32 1.05e-9 Schizophrenia; LUSC cis rs738322 0.967 rs133017 chr22:38572637 A/C cg25457927 chr22:38595422 NA -0.42 -8.93 -0.44 2.9e-17 Cutaneous nevi; LUSC cis rs67366981 0.844 rs8004209 chr14:77716474 T/C cg22824376 chr14:77648248 TMEM63C 0.62 5.88 0.31 1e-8 Obsessive-compulsive symptoms; LUSC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg03433033 chr1:76189801 ACADM 0.75 10.56 0.5 1.12e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs701145 0.556 rs355779 chr3:153977253 T/C cg17054900 chr3:154042577 DHX36 0.44 5.77 0.3 1.78e-8 Coronary artery disease; LUSC cis rs4917300 0.586 rs1352949 chr8:143096253 G/C cg25363559 chr8:143086065 NA -0.31 -7.01 -0.36 1.35e-11 Amyotrophic lateral sclerosis; LUSC cis rs2797160 1.000 rs1777225 chr6:126018270 T/C cg05901451 chr6:126070800 HEY2 0.57 8.58 0.43 3.59e-16 Endometrial cancer; LUSC cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -8.35 -0.42 1.84e-15 Bone mineral density; LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg19318889 chr4:1322082 MAEA 0.48 7.69 0.39 1.68e-13 Obesity-related traits; LUSC trans rs7819412 0.521 rs11777887 chr8:11036799 C/G cg08975724 chr8:8085496 FLJ10661 0.44 6.33 0.33 8.12e-10 Triglycerides; LUSC cis rs73195822 0.614 rs73194061 chr12:111221941 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.14 0.36 5.98e-12 Itch intensity from mosquito bite; LUSC cis rs17102423 0.723 rs8181937 chr14:65555707 A/C cg11161011 chr14:65562177 MAX -0.81 -12.4 -0.56 2.58e-29 Obesity-related traits; LUSC cis rs9300255 0.602 rs1716177 chr12:123655457 C/T cg00376283 chr12:123451042 ABCB9 0.65 8.22 0.41 4.63e-15 Neutrophil percentage of white cells; LUSC cis rs7568458 0.905 rs6714709 chr2:85756375 C/G cg02493740 chr2:85810744 VAMP5 -0.32 -5.69 -0.3 2.77e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg11752832 chr7:134001865 SLC35B4 0.5 7.09 0.36 7.81e-12 Mean platelet volume; LUSC cis rs12210905 0.688 rs12215353 chr6:27407022 C/T cg08851530 chr6:28072375 NA 0.93 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI; LUSC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg25124228 chr12:125621409 AACS -0.48 -7.14 -0.36 6e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs738322 0.600 rs6001035 chr22:38562425 A/G cg17652424 chr22:38574118 PLA2G6 -0.28 -5.9 -0.31 8.76e-9 Cutaneous nevi; LUSC cis rs2075671 0.903 rs62482250 chr7:100266057 C/T cg16850897 chr7:100343110 ZAN -0.53 -7.23 -0.37 3.38e-12 Other erythrocyte phenotypes; LUSC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.29e-11 Glomerular filtration rate (creatinine); LUSC cis rs2439831 0.702 rs495175 chr15:43798684 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.71 0.43 1.41e-16 Lung cancer in ever smokers; LUSC cis rs4285028 0.851 rs1986368 chr3:121710969 A/T cg11130432 chr3:121712080 ILDR1 -0.66 -10.04 -0.48 6.43e-21 Multiple sclerosis; LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg10802521 chr3:52805072 NEK4 -0.55 -8.69 -0.43 1.6e-16 Bipolar disorder; LUSC cis rs950169 0.614 rs765524 chr15:84681782 G/T cg17173187 chr15:85201210 NMB 0.36 5.77 0.3 1.85e-8 Schizophrenia; LUSC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg03785755 chr6:26196794 NA 0.53 5.66 0.3 3.24e-8 Gout;Renal underexcretion gout; LUSC trans rs11992162 0.967 rs7461062 chr8:11831948 T/C cg06636001 chr8:8085503 FLJ10661 0.58 8.32 0.41 2.26e-15 Monocyte count; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg18538332 chr22:24372958 LOC391322 -0.51 -8.83 -0.44 5.83e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6546550 0.901 rs13028508 chr2:70118427 A/T cg02498382 chr2:70120550 SNRNP27 0.28 7.09 0.36 7.8e-12 Prevalent atrial fibrillation; LUSC cis rs709400 0.663 rs11623869 chr14:103883633 G/T cg10523860 chr14:103875565 MARK3 -0.4 -6.29 -0.33 9.91e-10 Body mass index; LUSC cis rs11098499 0.698 rs4422403 chr4:120258194 C/T cg24375607 chr4:120327624 NA 0.72 11.69 0.54 1.04e-26 Corneal astigmatism; LUSC cis rs1832871 0.711 rs9459954 chr6:158709345 G/T cg07165851 chr6:158734300 TULP4 0.5 7.67 0.39 1.9e-13 Height; LUSC cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg07148914 chr20:33460835 GGT7 0.53 8.17 0.41 6.57e-15 Height; LUSC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg12463550 chr7:65579703 CRCP -0.51 -7.47 -0.38 7.17e-13 Aortic root size; LUSC cis rs225245 0.817 rs225255 chr17:33955243 A/G cg05299278 chr17:33885742 SLFN14 -0.31 -6.82 -0.35 4.39e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg08470875 chr2:26401718 FAM59B -0.67 -9.13 -0.45 6.46e-18 Gut microbiome composition (summer); LUSC cis rs9914988 0.943 rs9303621 chr17:27161138 A/G cg14438399 chr17:27053147 TLCD1 0.53 5.86 0.31 1.13e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1866706 0.896 rs4757062 chr11:12876491 C/T cg25843174 chr11:12811716 TEAD1 -0.28 -5.72 -0.3 2.36e-8 Intelligence (multi-trait analysis); LUSC trans rs72674100 1.000 rs4624660 chr4:97962814 T/A cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg03929089 chr4:120376271 NA 0.68 7.58 0.38 3.49e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg11764359 chr7:65958608 NA 0.81 13.52 0.59 1.62e-33 Aortic root size; LUSC cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -7.66 -0.39 2.01e-13 Schizophrenia; LUSC cis rs1348850 0.567 rs3821006 chr2:178537694 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.43 5.85 0.3 1.19e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs34779708 0.966 rs2045915 chr10:35418616 G/C cg04310649 chr10:35416472 CREM -0.41 -6.45 -0.33 3.96e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18279467 chr3:5020901 BHLHE40 0.37 6.18 0.32 1.89e-9 Asthma; LUSC cis rs9309473 0.519 rs2421584 chr2:73898852 G/A cg20560298 chr2:73613845 ALMS1 0.47 7.01 0.36 1.3e-11 Metabolite levels; LUSC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg23649088 chr2:200775458 C2orf69 -0.78 -14.48 -0.62 3.38e-37 Osteoporosis; LUSC cis rs4629180 0.630 rs10188189 chr2:102127926 A/G cg04415270 chr2:102091202 RFX8 -0.44 -7.61 -0.38 2.83e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs16854884 0.770 rs13091882 chr3:143818661 C/T cg06585982 chr3:143692056 C3orf58 0.45 6.74 0.35 6.88e-11 Economic and political preferences (feminism/equality); LUSC cis rs500891 0.525 rs1170341 chr6:84033239 A/C cg08257003 chr6:84140564 ME1 0.34 7.81 0.39 7.41e-14 Platelet-derived growth factor BB levels; LUSC cis rs7264396 0.666 rs1536147 chr20:34173046 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.45 6.61 0.34 1.49e-10 Total cholesterol levels; LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg20887711 chr4:1340912 KIAA1530 -0.7 -11.0 -0.52 3.11e-24 Longevity; LUSC cis rs12545109 0.800 rs1437278 chr8:57357024 T/C cg09654669 chr8:57350985 NA -0.56 -7.48 -0.38 6.83e-13 Obesity-related traits; LUSC cis rs8141797 0.818 rs1985047 chr22:24580381 G/C cg00411358 chr22:24577142 SUSD2 -0.53 -5.92 -0.31 8.03e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg22615462 chr19:17416451 MRPL34 0.75 6.05 0.31 3.91e-9 Cognitive performance; LUSC cis rs9660992 0.736 rs55673946 chr1:205250475 T/C cg21545522 chr1:205238299 TMCC2 0.48 9.1 0.45 8.33e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs478304 0.934 rs603645 chr11:65533000 A/C cg05805236 chr11:65401703 PCNXL3 0.4 6.79 0.35 5.06e-11 Acne (severe); LUSC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.57 -0.34 1.89e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg05347473 chr6:146136440 FBXO30 0.66 11.55 0.53 3.35e-26 Lobe attachment (rater-scored or self-reported); LUSC trans rs9630182 0.540 rs10832029 chr11:13399080 C/T cg00234616 chr2:74740572 TLX2 0.3 5.96 0.31 6.48e-9 Bone mineral density; LUSC cis rs4704187 0.532 rs75392670 chr5:74394968 A/G cg03227963 chr5:74354835 NA 0.31 6.65 0.34 1.19e-10 Response to amphetamines; LUSC cis rs2832077 0.943 rs4816336 chr21:30193519 C/T cg24692254 chr21:30365293 RNF160 -0.58 -7.22 -0.37 3.57e-12 Cognitive test performance; LUSC cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg08999081 chr20:33150536 PIGU 0.45 8.09 0.4 1.11e-14 Coronary artery disease; LUSC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg11584989 chr19:19387371 SF4 0.57 6.97 0.36 1.66e-11 Bipolar disorder; LUSC trans rs4332037 0.506 rs62442924 chr7:1989976 C/T cg25206134 chr2:45395956 NA 0.56 6.58 0.34 1.8e-10 Bipolar disorder; LUSC trans rs9944715 0.651 rs7228024 chr18:43782791 A/C cg01718231 chr17:29326311 RNF135 -0.51 -7.28 -0.37 2.48e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg03790207 chr6:42947109 PEX6 -0.46 -7.06 -0.36 9.53e-12 Plasma homocysteine levels (post-methionine load test); LUSC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.45 -0.5 2.57e-22 Schizophrenia; LUSC cis rs17155006 0.746 rs985152 chr7:107750357 G/A cg05962710 chr7:107745446 LAMB4 -0.36 -6.36 -0.33 6.54e-10 Pneumococcal bacteremia; LUSC cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg23649088 chr2:200775458 C2orf69 -0.5 -6.86 -0.35 3.41e-11 Schizophrenia; LUSC trans rs1728785 0.818 rs11075684 chr16:68582365 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.61 0.38 2.92e-13 Ulcerative colitis; LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg03354898 chr7:1950403 MAD1L1 -0.33 -6.43 -0.33 4.53e-10 Bipolar disorder and schizophrenia; LUSC trans rs2975734 0.709 rs4841298 chr8:10111637 G/A cg15556689 chr8:8085844 FLJ10661 -0.52 -6.48 -0.33 3.2e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg25427524 chr10:38739819 LOC399744 -0.74 -14.08 -0.61 1.14e-35 Extrinsic epigenetic age acceleration; LUSC cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.4e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg09177884 chr7:1199841 ZFAND2A -0.63 -9.23 -0.45 3.29e-18 Longevity;Endometriosis; LUSC cis rs12618769 0.597 rs3769734 chr2:99096149 A/T cg10123293 chr2:99228465 UNC50 0.47 7.67 0.39 1.89e-13 Bipolar disorder; LUSC cis rs9303401 0.592 rs66583824 chr17:56639853 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg04317338 chr11:64019027 PLCB3 -0.63 -7.17 -0.37 4.93e-12 Mean platelet volume; LUSC trans rs9329221 0.870 rs11777976 chr8:10255402 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.07 -0.44 1.07e-17 Neuroticism; LUSC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg04539111 chr16:67997858 SLC12A4 -0.46 -6.22 -0.32 1.52e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7131987 0.801 rs962866 chr12:29434147 A/G cg09582351 chr12:29534625 ERGIC2 -0.3 -6.31 -0.33 9.06e-10 QT interval; LUSC trans rs61931739 0.517 rs11053063 chr12:34181011 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.46e-16 Morning vs. evening chronotype; LUSC cis rs3892630 0.878 rs2903759 chr19:33195947 A/G cg22980127 chr19:33182716 NUDT19 0.94 12.79 0.57 9.57e-31 Red blood cell traits; LUSC cis rs7264396 0.563 rs73902913 chr20:34432784 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -7.81 -0.39 7.26e-14 Total cholesterol levels; LUSC cis rs2979489 0.891 rs4537262 chr8:30306757 T/A cg26383811 chr8:30366931 RBPMS 0.48 7.6 0.38 3.05e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs782590 0.574 rs12991445 chr2:55675939 C/T cg18811423 chr2:55921094 PNPT1 0.61 8.74 0.43 1.15e-16 Metabolic syndrome; LUSC cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg05347473 chr6:146136440 FBXO30 0.46 7.97 0.4 2.55e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1150668 0.830 rs2531831 chr6:28388765 C/G cg21251018 chr6:28226885 NKAPL 0.31 5.88 0.31 9.71e-9 Pubertal anthropometrics; LUSC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg13206674 chr6:150067644 NUP43 0.62 10.05 0.48 6.38e-21 Lung cancer; LUSC cis rs754466 0.651 rs10824583 chr10:79619402 C/T cg17075019 chr10:79541650 NA 0.74 11.82 0.54 3.64e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2742417 0.624 rs2673029 chr3:45758867 A/G cg10512202 chr3:45649293 LIMD1 0.36 6.13 0.32 2.53e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg01753270 chr2:239240285 TRAF3IP1 -0.42 -5.65 -0.3 3.48e-8 Multiple system atrophy; LUSC cis rs2190422 0.677 rs2906639 chr7:103074580 T/C cg04218035 chr7:103086829 SLC26A5 0.32 6.21 0.32 1.55e-9 Morning vs. evening chronotype; LUSC trans rs561341 0.609 rs9906443 chr17:30185565 C/T cg20587970 chr11:113659929 NA 0.81 9.68 0.47 1.06e-19 Hip circumference adjusted for BMI; LUSC cis rs2073300 0.609 rs12625164 chr20:23354269 T/C cg12062639 chr20:23401060 NAPB 0.97 7.93 0.4 3.23e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs2997457 0.818 rs298446 chr1:26305933 A/T cg26343958 chr12:5539662 NA -0.48 -6.01 -0.31 4.83e-9 Facial morphology (factor 16); LUSC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg18876405 chr7:65276391 NA 0.56 8.92 0.44 3.23e-17 Aortic root size; LUSC trans rs7980799 0.649 rs2389215 chr12:33649457 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.95 -0.31 6.71e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs10779751 0.734 rs2748878 chr1:11129434 T/C cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.65 0.57 3.22e-30 Prudent dietary pattern; LUSC cis rs9311676 0.656 rs11915190 chr3:58409700 G/A cg13750441 chr3:58318267 PXK 0.34 6.71 0.34 8.2e-11 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs9291683 0.546 rs13139055 chr4:10038924 G/T cg26043149 chr18:55253948 FECH 0.49 7.27 0.37 2.55e-12 Bone mineral density; LUSC cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg13683864 chr3:40499215 RPL14 1.0 17.13 0.68 1.15e-47 Renal cell carcinoma; LUSC cis rs1348850 0.958 rs10497501 chr2:178462299 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.93 0.31 7.38e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2729354 0.903 rs1846568 chr11:57357714 A/C cg24343310 chr11:57249947 NA 0.36 6.53 0.34 2.47e-10 Blood protein levels; LUSC cis rs2806561 0.704 rs7532266 chr1:23551623 A/C cg12483005 chr1:23474871 LUZP1 -0.43 -6.32 -0.33 8.51e-10 Height; LUSC cis rs1843834 0.624 rs2396110 chr2:225560219 A/G cg22455342 chr2:225449267 CUL3 0.44 5.78 0.3 1.72e-8 IgE levels in asthmatics (D.p. specific); LUSC cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg17892150 chr10:133769511 PPP2R2D -0.65 -8.84 -0.44 5.57e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs1994135 0.654 rs11052759 chr12:33724126 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.99 0.48 1.01e-20 Resting heart rate; LUSC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg03354898 chr7:1950403 MAD1L1 -0.33 -6.4 -0.33 5.27e-10 Schizophrenia; LUSC cis rs7903847 0.642 rs9887991 chr10:99159634 T/C cg08345082 chr10:99160200 RRP12 -0.34 -6.97 -0.36 1.71e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs2975734 0.709 rs4841298 chr8:10111637 G/A cg27411982 chr8:10470053 RP1L1 -0.42 -5.65 -0.3 3.39e-8 Morning vs. evening chronotype;Chronotype; LUSC cis rs1322512 1.000 rs2250514 chr6:153010920 C/T cg27316956 chr6:152958899 SYNE1 0.35 6.04 0.31 4.22e-9 Tonometry; LUSC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg03433033 chr1:76189801 ACADM 0.82 12.93 0.58 2.84e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9399135 0.933 rs7755680 chr6:135294259 A/G cg24558204 chr6:135376177 HBS1L 0.58 8.87 0.44 4.49e-17 Red blood cell count; LUSC trans rs1994135 0.715 rs11052742 chr12:33692290 A/C cg26384229 chr12:38710491 ALG10B 0.61 8.46 0.42 8.24e-16 Resting heart rate; LUSC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg25282410 chr6:160211355 TCP1;MRPL18 1.07 15.66 0.65 7.58e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg13114125 chr14:105738426 BRF1 -0.91 -15.8 -0.65 2.25e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.45 -5.7 -0.3 2.66e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs1493916 0.837 rs2172626 chr18:31410478 C/T cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC trans rs8072100 0.875 rs12451409 chr17:45544856 A/G cg03886242 chr7:26192032 NFE2L3 -0.42 -6.66 -0.34 1.11e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8114671 0.839 rs6142290 chr20:33654672 A/C cg07148914 chr20:33460835 GGT7 -0.46 -6.74 -0.35 7.17e-11 Height; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg03354898 chr7:1950403 MAD1L1 -0.35 -6.93 -0.35 2.13e-11 Bipolar disorder and schizophrenia; LUSC cis rs4891159 0.513 rs35534021 chr18:74130523 G/A cg24786174 chr18:74118243 ZNF516 0.94 20.34 0.74 2.08e-60 Longevity; LUSC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg20503657 chr10:835505 NA 1.21 16.15 0.66 9.48e-44 Eosinophil percentage of granulocytes; LUSC cis rs7659604 0.521 rs13130789 chr4:122690166 G/A cg20573242 chr4:122745356 CCNA2 -0.42 -6.07 -0.32 3.44e-9 Type 2 diabetes; LUSC cis rs3809566 0.963 rs3809565 chr15:63333619 A/G cg00520135 chr15:63333846 TPM1 -0.34 -6.63 -0.34 1.36e-10 Platelet count; LUSC cis rs2282032 0.766 rs17799268 chr14:90788934 G/T cg14092571 chr14:90743983 NA 0.48 5.88 0.31 9.97e-9 Longevity; LUSC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg13798780 chr7:105162888 PUS7 0.56 6.12 0.32 2.55e-9 Bipolar disorder (body mass index interaction); LUSC cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg00852783 chr1:26633632 UBXN11 0.61 9.63 0.47 1.58e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg27535305 chr1:53392650 SCP2 0.39 7.27 0.37 2.52e-12 Monocyte count; LUSC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.59 -0.43 3.45e-16 Neuroticism; LUSC cis rs16949788 1.000 rs41315964 chr15:66779698 C/T cg08120210 chr15:66682733 MAP2K1 -0.6 -6.3 -0.33 9.41e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg13670615 chr19:49140625 SEC1;DBP 0.42 5.99 0.31 5.38e-9 Neuroticism; LUSC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg13866156 chr1:1669148 SLC35E2 -0.51 -8.19 -0.41 5.68e-15 Body mass index; LUSC cis rs765787 0.530 rs1706764 chr15:45524256 T/A cg25801113 chr15:45476975 SHF 0.35 7.37 0.37 1.39e-12 Uric acid levels; LUSC cis rs7267979 1.000 rs6083813 chr20:25337671 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.02 -0.74 4.03e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12602172 1 rs12602172 chr17:38163567 G/A cg17467752 chr17:38218738 THRA 0.77 12.45 0.56 1.7e-29 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs56283067 0.578 rs2894641 chr6:45393174 A/G cg18551225 chr6:44695536 NA -0.4 -5.82 -0.3 1.41e-8 Total body bone mineral density; LUSC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.36 0.53 1.66e-25 Menopause (age at onset); LUSC cis rs10740039 0.516 rs7072017 chr10:62344326 A/G cg18175470 chr10:62150864 ANK3 -0.45 -6.81 -0.35 4.6e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03074984 chr11:64126431 RPS6KA4 -0.46 -6.65 -0.34 1.22e-10 Hepatitis; LUSC trans rs7824557 0.628 rs7005469 chr8:11194457 G/A cg15556689 chr8:8085844 FLJ10661 0.47 6.96 0.36 1.84e-11 Retinal vascular caliber; LUSC cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.16e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg25019033 chr10:957182 NA -0.53 -6.1 -0.32 2.91e-9 Eosinophil percentage of granulocytes; LUSC cis rs12310956 0.510 rs10844693 chr12:33865197 A/G cg06521331 chr12:34319734 NA 0.36 5.91 0.31 8.25e-9 Morning vs. evening chronotype; LUSC cis rs6500395 1.000 rs9933314 chr16:48676608 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.86e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs7824557 0.701 rs2060465 chr8:11162609 T/C cg08975724 chr8:8085496 FLJ10661 0.45 6.67 0.34 1.09e-10 Retinal vascular caliber; LUSC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg04398451 chr17:18023971 MYO15A 0.44 6.91 0.35 2.5e-11 Total body bone mineral density; LUSC cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg06627628 chr2:24431161 ITSN2 -0.61 -7.4 -0.38 1.09e-12 Lymphocyte counts; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg15147215 chr3:52552868 STAB1 -0.32 -5.8 -0.3 1.55e-8 Bipolar disorder; LUSC cis rs6964587 1.000 rs6961928 chr7:91669808 C/T cg17063962 chr7:91808500 NA 0.55 8.73 0.43 1.2e-16 Breast cancer; LUSC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg06671706 chr8:8559999 CLDN23 0.49 6.47 0.33 3.55e-10 Obesity-related traits; LUSC cis rs7615316 1.000 rs7615316 chr3:142355926 G/A cg16271453 chr3:142027066 XRN1 -0.34 -5.74 -0.3 2.09e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs936229 0.749 rs6495126 chr15:75175026 C/T cg10253484 chr15:75165896 SCAMP2 0.6 8.34 0.42 1.91e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14476756 chr9:136243436 C9orf96;SURF4 0.41 6.14 0.32 2.32e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg15145296 chr3:125709740 NA 0.55 6.17 0.32 1.93e-9 Blood pressure (smoking interaction); LUSC cis rs472402 0.580 rs8192186 chr5:6652009 G/A cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.53 -7.68 -0.39 1.74e-13 Response to amphetamines; LUSC cis rs16854884 0.657 rs16854816 chr3:143734147 A/G cg06585982 chr3:143692056 C3orf58 0.5 8.13 0.41 8.55e-15 Economic and political preferences (feminism/equality); LUSC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg24110177 chr3:50126178 RBM5 -0.57 -9.36 -0.46 1.25e-18 Intelligence (multi-trait analysis); LUSC cis rs8038465 0.615 rs11072430 chr15:73981701 A/G cg15420318 chr15:73925796 NPTN -0.55 -9.22 -0.45 3.45e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3018712 0.532 rs10791988 chr11:68416051 A/T cg22747802 chr11:68417633 NA -0.41 -5.65 -0.3 3.5e-8 Total body bone mineral density; LUSC cis rs73198271 0.628 rs74433718 chr8:8591546 A/C cg01851573 chr8:8652454 MFHAS1 0.46 5.77 0.3 1.83e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs734999 0.549 rs867436 chr1:2523723 C/T cg18854424 chr1:2615690 NA 0.48 9.49 0.46 4.53e-19 Ulcerative colitis; LUSC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg26380479 chr7:97908229 NA -0.27 -6.02 -0.31 4.57e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9807989 0.839 rs10182710 chr2:102981306 A/G cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs8017423 0.967 rs11623275 chr14:90721335 C/T cg04374321 chr14:90722782 PSMC1 0.75 12.12 0.55 2.92e-28 Mortality in heart failure; LUSC cis rs909341 0.909 rs1151624 chr20:62369895 A/G cg09650180 chr20:62225654 GMEB2 0.44 5.67 0.3 3.13e-8 Atopic dermatitis; LUSC trans rs61931739 0.500 rs11053167 chr12:34387092 A/C cg26384229 chr12:38710491 ALG10B 0.9 15.63 0.65 1.05e-41 Morning vs. evening chronotype; LUSC trans rs2243480 1.000 rs402418 chr7:65509469 G/A cg10756647 chr7:56101905 PSPH 0.87 8.53 0.42 5.33e-16 Diabetic kidney disease; LUSC cis rs7799006 0.593 rs12531150 chr7:2289888 C/T cg12823233 chr7:2316876 SNX8 -0.47 -8.03 -0.4 1.72e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg06221963 chr1:154839813 KCNN3 0.45 9.09 0.45 9.29e-18 Schizophrenia; LUSC cis rs8072100 0.667 rs1912485 chr17:45515678 T/G cg08085267 chr17:45401833 C17orf57 -0.51 -7.3 -0.37 2.07e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg23791538 chr6:167370224 RNASET2 -0.41 -6.45 -0.33 3.87e-10 Crohn's disease; LUSC cis rs250677 0.524 rs417413 chr5:148452726 T/C cg12140854 chr5:148520817 ABLIM3 -0.34 -6.06 -0.31 3.68e-9 Breast cancer; LUSC trans rs66887589 0.616 rs10032299 chr4:120206419 C/T cg25214090 chr10:38739885 LOC399744 0.38 6.04 0.31 4.1e-9 Diastolic blood pressure; LUSC cis rs2439831 0.850 rs2957637 chr15:43951118 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.41 0.38 1.05e-12 Lung cancer in ever smokers; LUSC cis rs9650657 0.769 rs1968400 chr8:10615431 G/C cg27411982 chr8:10470053 RP1L1 -0.37 -6.05 -0.31 3.8e-9 Neuroticism; LUSC cis rs7833986 0.534 rs17759244 chr8:57033768 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.13 0.55 2.66e-28 Height; LUSC trans rs9929218 1.000 rs4783681 chr16:68806508 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -11.75 -0.54 6.51e-27 Colorectal cancer; LUSC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg17143192 chr8:8559678 CLDN23 0.63 8.9 0.44 3.56e-17 Obesity-related traits; LUSC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg18876405 chr7:65276391 NA -0.54 -8.5 -0.42 6.26e-16 Aortic root size; LUSC cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg21535247 chr6:8435926 SLC35B3 0.6 9.46 0.46 5.68e-19 Motion sickness; LUSC cis rs8141529 0.748 rs132529 chr22:29296652 A/G cg02153584 chr22:29168773 CCDC117 -0.56 -8.47 -0.42 7.91e-16 Lymphocyte counts; LUSC cis rs9815354 0.680 rs73073291 chr3:42028004 G/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs11098499 0.955 rs13113112 chr4:120156040 C/T cg09307838 chr4:120376055 NA 0.72 10.44 0.5 2.81e-22 Corneal astigmatism; LUSC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg00933542 chr6:150070202 PCMT1 -0.32 -6.85 -0.35 3.64e-11 Lung cancer; LUSC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg10756475 chr4:1757242 NA -0.36 -5.82 -0.3 1.41e-8 Bladder cancer;Urinary bladder cancer; LUSC cis rs3772130 0.962 rs4311252 chr3:121514161 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.07 0.48 5.45e-21 Cognitive performance; LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.62 0.34 1.47e-10 Menopause (age at onset); LUSC cis rs911119 0.908 rs8114619 chr20:23601813 G/T cg16589663 chr20:23618590 CST3 0.58 6.91 0.35 2.48e-11 Chronic kidney disease; LUSC cis rs4654899 0.865 rs6693020 chr1:21378057 A/G cg01072550 chr1:21505969 NA -0.54 -7.9 -0.4 4.21e-14 Superior frontal gyrus grey matter volume; LUSC cis rs2073300 1.000 rs2073300 chr20:23471681 T/G cg09953122 chr20:23471693 CST8 -0.87 -7.06 -0.36 9.78e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg00484396 chr16:3507460 NAT15 -0.84 -10.54 -0.5 1.26e-22 Tuberculosis; LUSC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg03929089 chr4:120376271 NA -0.94 -16.46 -0.67 5.66e-45 Height; LUSC cis rs427941 0.703 rs201458 chr7:101741439 T/C cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs9326248 0.569 rs10892082 chr11:117039325 A/C cg26566898 chr11:117069891 TAGLN 0.43 5.77 0.3 1.82e-8 Blood protein levels; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg11494091 chr17:61959527 GH2 0.65 13.75 0.6 2.1e-34 Prudent dietary pattern; LUSC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg25258033 chr6:167368657 RNASET2 -0.47 -7.95 -0.4 2.87e-14 Crohn's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19987288 chr12:56122958 CD63 -0.48 -6.43 -0.33 4.49e-10 Bipolar disorder and schizophrenia; LUSC cis rs3815700 1.000 rs8100168 chr19:33093084 G/A cg02997394 chr19:33096574 ANKRD27 0.71 7.18 0.37 4.43e-12 Eosinophilic esophagitis; LUSC cis rs9359856 0.510 rs17294495 chr6:90445753 T/G cg13799429 chr6:90582589 CASP8AP2 -0.92 -10.79 -0.51 1.8e-23 Bipolar disorder; LUSC trans rs9944715 0.954 rs62096525 chr18:43743820 G/A cg01718231 chr17:29326311 RNF135 0.48 6.79 0.35 5.09e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs8005677 1.000 rs8006409 chr14:23396511 A/G cg00579484 chr14:23475993 C14orf93 0.39 5.78 0.3 1.72e-8 Cognitive ability (multi-trait analysis); LUSC cis rs9325144 0.647 rs7316392 chr12:39064381 T/G cg13010199 chr12:38710504 ALG10B -0.51 -7.79 -0.39 8.66e-14 Morning vs. evening chronotype; LUSC trans rs11098499 0.657 rs9996569 chr4:120299004 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs10089 0.953 rs17164427 chr5:127361736 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.85 -11.77 -0.54 5.46e-27 Ileal carcinoids; LUSC cis rs17270561 0.609 rs1179086 chr6:25791745 A/T cg17691542 chr6:26056736 HIST1H1C 0.46 6.56 0.34 2.02e-10 Iron status biomarkers; LUSC cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg18681998 chr4:17616180 MED28 0.85 15.66 0.65 8.11e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg09033563 chr22:24373618 LOC391322 -0.66 -10.42 -0.5 3.36e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2404602 0.647 rs920712 chr15:77033934 G/A cg23625390 chr15:77176239 SCAPER -0.66 -10.08 -0.48 4.95e-21 Blood metabolite levels; LUSC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg14983838 chr19:29218262 NA 0.65 9.21 0.45 3.57e-18 Methadone dose in opioid dependence; LUSC cis rs10791097 0.506 rs10750446 chr11:130706918 T/C cg12179176 chr11:130786555 SNX19 -0.55 -8.13 -0.41 8.32e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs1580019 0.961 rs1610143 chr7:32498331 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.86 0.54 2.63e-27 Cognitive ability; LUSC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg11062466 chr8:58055876 NA 0.64 8.3 0.41 2.57e-15 Developmental language disorder (linguistic errors); LUSC cis rs2228479 0.541 rs62052173 chr16:89950739 T/C cg06558623 chr16:89946397 TCF25 0.95 10.21 0.49 1.82e-21 Skin colour saturation; LUSC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.64 -0.57 3.31e-30 Platelet count; LUSC cis rs929596 0.564 rs2741027 chr2:234518011 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.37 -0.33 6.31e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC cis rs1044826 1.000 rs34742758 chr3:139218378 C/G cg00490450 chr3:139108681 COPB2 0.51 6.8 0.35 4.8e-11 Obesity-related traits; LUSC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg03351412 chr1:154909251 PMVK 0.49 7.76 0.39 1.05e-13 Prostate cancer; LUSC cis rs10992471 0.603 rs7033979 chr9:95223980 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.75 -0.39 1.15e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs4729127 1.000 rs7799378 chr7:94007546 C/G cg20086523 chr13:52378287 DHRS12 -0.51 -6.02 -0.31 4.6e-9 Intelligence; LUSC cis rs6835098 0.924 rs7672108 chr4:174165126 A/G cg08422745 chr4:174089978 GALNT7 0.75 12.71 0.57 1.78e-30 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.77e-30 Motion sickness; LUSC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg10621924 chr7:39171070 POU6F2 0.45 7.17 0.37 4.91e-12 IgG glycosylation; LUSC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg12463550 chr7:65579703 CRCP 0.43 6.17 0.32 2.01e-9 Calcium levels; LUSC trans rs9467603 1.000 rs9467609 chr6:25809751 A/G cg06606381 chr12:133084897 FBRSL1 -0.61 -5.95 -0.31 6.75e-9 Intelligence (multi-trait analysis); LUSC cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg24812749 chr6:127587940 RNF146 0.71 10.21 0.49 1.76e-21 Breast cancer; LUSC cis rs9311676 0.609 rs11925862 chr3:58417927 A/C cg26110898 chr3:58419937 PDHB 0.4 6.4 0.33 5.22e-10 Systemic lupus erythematosus; LUSC cis rs11098499 0.954 rs34858317 chr4:120387110 A/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.59e-25 Corneal astigmatism; LUSC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg20573242 chr4:122745356 CCNA2 0.66 10.43 0.5 3.07e-22 Type 2 diabetes; LUSC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg05872129 chr22:39784769 NA -0.55 -8.9 -0.44 3.59e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11048434 0.736 rs11048338 chr12:9121362 C/G cg13575925 chr12:9217583 LOC144571 0.33 6.03 0.31 4.23e-9 Sjögren's syndrome; LUSC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2067615 0.524 rs4964186 chr12:107080235 C/T cg15890332 chr12:107067104 RFX4 0.36 6.24 0.32 1.35e-9 Heart rate; LUSC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg13560548 chr3:10150139 C3orf24 0.48 6.9 0.35 2.69e-11 Alzheimer's disease; LUSC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg22875332 chr1:76189707 ACADM 0.74 10.31 0.49 7.84e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs16917546 1.000 rs10995258 chr10:64408787 C/T cg03961010 chr10:64397487 ZNF365 -0.42 -6.7 -0.34 8.95e-11 Basal cell carcinoma; LUSC cis rs6426558 0.537 rs6692080 chr1:227390162 C/T cg10327440 chr1:227177885 CDC42BPA -0.53 -7.19 -0.37 4.2e-12 Neutrophil percentage of white cells; LUSC cis rs3829251 0.786 rs7103591 chr11:71237619 T/C cg05163923 chr11:71159392 DHCR7 -0.67 -7.05 -0.36 1.02e-11 Vitamin D levels; LUSC cis rs9486719 1.000 rs3906199 chr6:97049899 C/A cg06623918 chr6:96969491 KIAA0776 -0.84 -10.5 -0.5 1.72e-22 Migraine;Coronary artery disease; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg07791671 chr2:242255336 SEPT2;HDLBP 0.47 6.29 0.33 9.94e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg26850624 chr5:429559 AHRR -0.43 -8.43 -0.42 1.08e-15 Cystic fibrosis severity; LUSC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg05313129 chr8:58192883 C8orf71 -0.58 -6.29 -0.33 9.86e-10 Developmental language disorder (linguistic errors); LUSC cis rs7572733 0.534 rs700670 chr2:198687284 T/C cg00792783 chr2:198669748 PLCL1 0.43 5.69 0.3 2.79e-8 Dermatomyositis; LUSC cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14240646 chr10:27532245 ACBD5 0.71 8.19 0.41 5.71e-15 Breast cancer; LUSC cis rs9648716 0.515 rs38732 chr7:140705162 A/T cg23214464 chr7:140373596 ADCK2 0.72 6.24 0.32 1.34e-9 Type 2 diabetes; LUSC cis rs3741151 0.773 rs57354084 chr11:73139376 A/T cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs939658 0.805 rs6495374 chr15:79434031 C/T cg17916960 chr15:79447300 NA -0.52 -10.39 -0.49 4.32e-22 Refractive error; LUSC cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.11 0.32 2.83e-9 Rheumatoid arthritis; LUSC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg23711669 chr6:146136114 FBXO30 0.87 16.53 0.67 2.75e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg08999081 chr20:33150536 PIGU 0.37 6.82 0.35 4.34e-11 Height; LUSC trans rs6502050 0.835 rs34287733 chr17:80078236 C/T cg07393940 chr7:158741817 NA -0.37 -6.64 -0.34 1.24e-10 Life satisfaction; LUSC trans rs6952808 1.000 rs59248873 chr7:1888185 A/G cg24247370 chr13:99142703 STK24 -0.35 -6.38 -0.33 5.82e-10 Bipolar disorder and schizophrenia; LUSC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Vitiligo; LUSC cis rs7759001 0.857 rs10807022 chr6:27362598 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs2179367 0.600 rs9498352 chr6:149760244 A/G cg07828024 chr6:149772892 ZC3H12D -0.35 -5.87 -0.31 1.03e-8 Dupuytren's disease; LUSC cis rs500891 0.525 rs7758989 chr6:84061319 T/C cg08257003 chr6:84140564 ME1 0.34 8.34 0.42 1.98e-15 Platelet-derived growth factor BB levels; LUSC cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg13010199 chr12:38710504 ALG10B -0.61 -9.63 -0.47 1.53e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg02527881 chr3:46936655 PTH1R -0.4 -7.26 -0.37 2.73e-12 Colorectal cancer; LUSC cis rs2274273 0.686 rs66842809 chr14:55630571 T/C cg04306507 chr14:55594613 LGALS3 0.48 9.76 0.47 5.79e-20 Protein biomarker; LUSC cis rs11098499 0.818 rs7688802 chr4:120451668 G/A cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs2439831 0.681 rs7175434 chr15:43628542 A/C cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.15 0.64 7.69e-40 Lung cancer in ever smokers; LUSC cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg26384229 chr12:38710491 ALG10B 0.87 14.78 0.63 2.2e-38 Bladder cancer; LUSC cis rs11048434 0.736 rs2377674 chr12:9112761 A/G cg23795048 chr12:9217529 LOC144571 0.34 6.01 0.31 4.82e-9 Sjögren's syndrome; LUSC cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs73198271 1.000 rs11784958 chr8:8607781 C/A cg01851573 chr8:8652454 MFHAS1 0.58 8.04 0.4 1.55e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg22509189 chr2:225307070 NA 0.46 6.02 0.31 4.64e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs12286929 0.661 rs7947402 chr11:115088420 T/C cg04055981 chr11:115044050 NA 0.4 6.9 0.35 2.57e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4631830 0.832 rs1585378 chr10:51523213 A/T cg10326726 chr10:51549505 MSMB -0.35 -5.94 -0.31 7.02e-9 Prostate-specific antigen levels; LUSC cis rs3617 0.503 rs9866243 chr3:52915219 C/T cg11645453 chr3:52864694 ITIH4 -0.4 -9.24 -0.45 2.94e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg12219531 chr12:120966889 COQ5 0.61 8.09 0.4 1.1e-14 High light scatter reticulocyte count; LUSC cis rs8064299 0.597 rs2166703 chr17:72781812 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.93 19.06 0.72 2.39e-55 Monocyte count; LUSC cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.33 0.45 1.55e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg04539111 chr16:67997858 SLC12A4 -0.47 -6.42 -0.33 4.7e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs6951245 0.938 rs117729148 chr7:1108531 G/A cg13565492 chr6:43139072 SRF -0.63 -6.59 -0.34 1.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg09509183 chr1:209979624 IRF6 0.53 6.29 0.33 9.68e-10 Cleft lip with or without cleft palate; LUSC cis rs11214589 0.905 rs12804573 chr11:113241726 G/A cg14159747 chr11:113255604 NA 0.29 7.01 0.36 1.33e-11 Neuroticism; LUSC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg06873352 chr17:61820015 STRADA 0.7 12.77 0.57 1.14e-30 Prudent dietary pattern; LUSC cis rs6942756 0.955 rs55638303 chr7:128885770 C/T cg02491457 chr7:128862824 NA -0.52 -7.42 -0.38 9.94e-13 White matter hyperintensity burden; LUSC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg14552801 chr7:65878734 NA -0.43 -5.95 -0.31 6.61e-9 Aortic root size; LUSC cis rs612683 0.517 rs3767832 chr1:100943100 A/G cg09408571 chr1:101003634 GPR88 -0.33 -6.68 -0.34 9.99e-11 Breast cancer; LUSC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs12310956 0.532 rs1525903 chr12:33964163 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.93 0.51 5.75e-24 Morning vs. evening chronotype; LUSC cis rs4780355 0.918 rs243323 chr16:11361202 A/G cg00044050 chr16:11439710 C16orf75 0.56 8.39 0.42 1.35e-15 Crohn's disease and psoriasis; LUSC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg20243544 chr17:37824526 PNMT 0.48 6.21 0.32 1.59e-9 Glomerular filtration rate (creatinine); LUSC cis rs1348850 0.872 rs4893959 chr2:178400204 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.58 0.38 3.39e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7589342 0.536 rs10201738 chr2:106386294 C/T cg09152813 chr2:106391379 NCK2 -0.37 -6.07 -0.32 3.43e-9 Addiction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00671161 chr13:52586367 ALG11;ATP7B 0.52 7.22 0.37 3.56e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4595586 0.545 rs1562729 chr12:39406179 T/G cg13010199 chr12:38710504 ALG10B 0.41 5.9 0.31 8.95e-9 Morning vs. evening chronotype; LUSC cis rs9506514 0.722 rs10400670 chr13:21253489 G/A cg04906043 chr13:21280425 IL17D -0.3 -5.66 -0.3 3.31e-8 Coronary artery calcification; LUSC cis rs7113850 0.541 rs7944769 chr11:24224823 G/C ch.11.24196551F chr11:24239977 NA 0.99 9.0 0.44 1.76e-17 Bone fracture in osteoporosis; LUSC cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9349203 1 rs9349203 chr6:41893323 G/A cg17623882 chr6:41773611 USP49 -0.62 -10.19 -0.49 2.11e-21 Menarche (age at onset); LUSC cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg06028605 chr16:24865363 SLC5A11 0.48 8.33 0.41 2.16e-15 Intelligence (multi-trait analysis); LUSC cis rs6545883 0.826 rs777593 chr2:61419103 C/A cg15711740 chr2:61764176 XPO1 -0.43 -6.55 -0.34 2.22e-10 Tuberculosis; LUSC cis rs11209002 0.545 rs2093332 chr1:67531974 G/A cg02640540 chr1:67518911 SLC35D1 0.6 8.17 0.41 6.36e-15 Crohn's disease; LUSC cis rs1865760 0.963 rs9356991 chr6:25901758 C/A cg17691542 chr6:26056736 HIST1H1C 0.45 6.76 0.35 6.12e-11 Height; LUSC cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg18132916 chr6:79620363 NA -0.4 -6.14 -0.32 2.4e-9 Intelligence (multi-trait analysis); LUSC cis rs425277 0.917 rs12410859 chr1:2038732 C/T cg03732007 chr1:2071316 PRKCZ 0.45 7.21 0.37 3.81e-12 Height; LUSC cis rs765787 0.530 rs12439643 chr15:45529767 A/G cg24006582 chr15:45444508 DUOX1 0.65 9.5 0.46 4.16e-19 Uric acid levels; LUSC trans rs7726839 0.526 rs55647623 chr5:567747 T/C cg25482853 chr8:67687455 SGK3 1.02 16.28 0.67 2.82e-44 Obesity-related traits; LUSC cis rs9815354 0.812 rs73073323 chr3:41834051 C/T cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs11105298 0.891 rs10858869 chr12:89857611 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.22 -0.37 3.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC trans rs12210905 1.000 rs7759955 chr6:26709424 G/A cg11837749 chr1:55047332 ACOT11 0.56 5.99 0.31 5.28e-9 Hip circumference adjusted for BMI; LUSC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg16339924 chr4:17578868 LAP3 0.55 8.42 0.42 1.11e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.67 0.43 1.87e-16 Menarche (age at onset); LUSC trans rs61931739 0.534 rs11053000 chr12:34079022 C/T cg26384229 chr12:38710491 ALG10B 0.71 11.24 0.52 4.36e-25 Morning vs. evening chronotype; LUSC cis rs4285028 0.948 rs12630486 chr3:121685267 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.59 -0.46 2.19e-19 Multiple sclerosis; LUSC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg21017887 chr14:105400489 NA 0.68 13.32 0.59 8.93e-33 Rheumatoid arthritis; LUSC cis rs9309473 0.519 rs13017182 chr2:73891004 G/T cg20560298 chr2:73613845 ALMS1 0.44 6.92 0.35 2.33e-11 Metabolite levels; LUSC trans rs12431204 0.874 rs1538145 chr13:38445304 A/T cg25252598 chr12:6641602 NA 0.37 6.31 0.33 8.77e-10 Schizophrenia; LUSC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg06494592 chr3:125709126 NA -0.51 -5.91 -0.31 8.67e-9 Blood pressure (smoking interaction); LUSC cis rs1448094 0.842 rs7309725 chr12:86440612 T/C cg00310523 chr12:86230176 RASSF9 0.36 6.51 0.34 2.72e-10 Major depressive disorder; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg15117754 chr3:10150083 C3orf24 0.43 5.7 0.3 2.59e-8 Alzheimer's disease; LUSC cis rs10791097 0.694 rs6590520 chr11:130747386 C/G cg12179176 chr11:130786555 SNX19 0.85 15.03 0.64 2.24e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg13114125 chr14:105738426 BRF1 0.89 15.74 0.65 3.64e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.1e-12 Motion sickness; LUSC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg08085267 chr17:45401833 C17orf57 -0.53 -7.65 -0.39 2.13e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8044995 0.563 rs7500163 chr16:68364358 C/G cg05110241 chr16:68378359 PRMT7 -0.74 -8.43 -0.42 1.03e-15 Schizophrenia; LUSC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg05425664 chr17:57184151 TRIM37 0.54 7.98 0.4 2.31e-14 Intelligence (multi-trait analysis); LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg08859206 chr1:53392774 SCP2 0.5 8.66 0.43 2e-16 Monocyte count; LUSC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg01368799 chr11:117014884 PAFAH1B2 0.57 8.76 0.43 9.65e-17 Blood protein levels; LUSC cis rs9532580 0.710 rs9577090 chr13:41225228 G/T cg21288729 chr13:41239152 FOXO1 0.63 9.68 0.47 1.06e-19 Mean corpuscular hemoglobin; LUSC cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg13535736 chr9:111863775 C9orf5 -0.39 -6.39 -0.33 5.53e-10 Menarche (age at onset); LUSC cis rs7945705 0.837 rs10769966 chr11:8847041 C/A cg12365402 chr11:9010492 NRIP3 0.36 6.2 0.32 1.63e-9 Hemoglobin concentration; LUSC cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg20503657 chr10:835505 NA 0.62 7.9 0.4 4.14e-14 Eosinophil percentage of granulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09854653 chr6:163834903 QKI -0.4 -6.16 -0.32 2.04e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.7 -0.3 2.69e-8 Depression; LUSC cis rs2806561 0.514 rs11801120 chr1:23543307 C/T cg19743168 chr1:23544995 NA 0.56 10.84 0.51 1.16e-23 Height; LUSC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.18 -0.32 1.82e-9 Total body bone mineral density; LUSC trans rs7615952 0.641 rs7640158 chr3:125808011 G/A cg07211511 chr3:129823064 LOC729375 -0.75 -9.68 -0.47 1.1e-19 Blood pressure (smoking interaction); LUSC cis rs9314323 0.729 rs7823021 chr8:26224958 G/T cg13160058 chr8:26243215 BNIP3L -0.4 -7.16 -0.36 5.32e-12 Red cell distribution width; LUSC cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.66e-8 Morning vs. evening chronotype; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2467099 0.732 rs2168855 chr17:73943350 C/T cg19302996 chr17:73780495 UNK -0.5 -5.76 -0.3 1.96e-8 Systolic blood pressure; LUSC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg20503657 chr10:835505 NA 1.05 13.48 0.59 2.19e-33 Eosinophil percentage of granulocytes; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.77 0.39 9.93e-14 Lymphocyte counts; LUSC cis rs12711979 0.765 rs7559461 chr2:3818623 G/A cg17052675 chr2:3827356 NA -0.57 -11.28 -0.53 3.32e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg18758796 chr5:131593413 PDLIM4 -0.42 -6.51 -0.34 2.77e-10 Breast cancer; LUSC cis rs4363385 0.818 rs435633 chr1:153011811 A/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs10761482 0.861 rs10761486 chr10:62104303 C/T cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs6087990 0.701 rs1997797 chr20:31387954 C/G cg13636640 chr20:31349939 DNMT3B 0.91 18.56 0.71 2.37e-53 Ulcerative colitis; LUSC trans rs3774749 0.565 rs2624839 chr3:50202231 T/C cg21659725 chr3:3221576 CRBN 0.48 7.18 0.37 4.67e-12 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg08132940 chr7:1081526 C7orf50 -0.52 -6.27 -0.32 1.11e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7084921 0.521 rs12772820 chr10:101873824 A/G cg02250046 chr10:101825185 CPN1 -0.31 -5.78 -0.3 1.73e-8 Bone mineral density; LUSC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg17554472 chr22:41940697 POLR3H 0.48 5.95 0.31 6.68e-9 Vitiligo; LUSC cis rs1003719 0.762 rs1015551 chr21:38449510 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.42 0.53 9.82e-26 Eye color traits; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg27094323 chr7:1216898 NA -0.34 -5.71 -0.3 2.55e-8 Longevity;Endometriosis; LUSC cis rs7560272 0.538 rs17434634 chr2:73922926 T/A cg20560298 chr2:73613845 ALMS1 0.4 6.12 0.32 2.55e-9 Schizophrenia; LUSC cis rs950027 0.620 rs1145084 chr15:45675440 G/A cg21132104 chr15:45694354 SPATA5L1 0.4 5.92 0.31 8.03e-9 Response to fenofibrate (adiponectin levels); LUSC trans rs7937682 0.889 rs10749984 chr11:111492861 T/C cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs1997103 0.765 rs55686950 chr7:55396552 A/C cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6964587 0.626 rs10234074 chr7:91520119 C/T cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs7385804 0.761 rs1734908 chr7:100313768 G/T cg16850897 chr7:100343110 ZAN 0.36 5.75 0.3 1.99e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21923990 chr19:8408412 KANK3 0.41 5.99 0.31 5.39e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg19920283 chr7:105172520 RINT1 0.57 5.97 0.31 5.98e-9 Bipolar disorder (body mass index interaction); LUSC cis rs11098499 0.754 rs1980027 chr4:120251577 C/T cg09307838 chr4:120376055 NA 0.7 10.58 0.5 9.21e-23 Corneal astigmatism; LUSC cis rs73206853 0.563 rs1050587 chr12:111158161 T/C cg12870014 chr12:110450643 ANKRD13A 0.67 7.4 0.38 1.13e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs17253792 0.822 rs79873916 chr14:56172631 G/C cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg18306943 chr3:40428807 ENTPD3 0.38 5.72 0.3 2.34e-8 Renal cell carcinoma; LUSC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs8040855 0.599 rs4643289 chr15:85726714 C/T cg04831495 chr15:85060580 GOLGA6L5 0.41 6.85 0.35 3.67e-11 Bulimia nervosa; LUSC cis rs68170813 0.559 rs4730231 chr7:106942039 G/C cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.64 -0.3 3.56e-8 Coronary artery disease; LUSC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg26587870 chr6:27730563 NA -0.64 -6.07 -0.32 3.42e-9 Depression; LUSC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.15 15.28 0.64 2.48e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg25072359 chr17:41440525 NA 0.66 9.45 0.46 6.13e-19 Menopause (age at onset); LUSC cis rs561341 0.883 rs6505274 chr17:30344581 G/T cg00745463 chr17:30367425 LRRC37B -0.69 -8.78 -0.43 8.94e-17 Hip circumference adjusted for BMI; LUSC cis rs9467773 0.967 rs6941022 chr6:26553531 T/C cg09904177 chr6:26538194 HMGN4 0.75 14.04 0.61 1.66e-35 Intelligence (multi-trait analysis); LUSC trans rs2243480 1.000 rs6958420 chr7:65751171 A/G cg10756647 chr7:56101905 PSPH -0.87 -8.66 -0.43 2.02e-16 Diabetic kidney disease; LUSC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.63 0.65 9.98e-42 Platelet count; LUSC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.37 -0.46 1.12e-18 Mood instability; LUSC cis rs9549367 0.713 rs9549356 chr13:113851633 A/G cg18105134 chr13:113819100 PROZ -0.76 -10.64 -0.5 5.78e-23 Platelet distribution width; LUSC cis rs748404 0.697 rs493177 chr15:43543258 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.48 7.8 0.39 8.05e-14 Lung cancer; LUSC cis rs9300255 0.602 rs1716164 chr12:123663660 G/A cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.37 -0.33 6.33e-10 Neutrophil percentage of white cells; LUSC cis rs12367572 0.796 rs7979141 chr12:45282630 A/T cg04608330 chr12:45269318 NELL2 -0.58 -9.4 -0.46 9.25e-19 Gut microbiome composition (summer); LUSC trans rs61931739 0.500 rs12371415 chr12:34521362 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.4 0.64 8.6e-41 Morning vs. evening chronotype; LUSC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg19729930 chr2:74357872 NA 0.89 16.74 0.68 4.36e-46 Gestational age at birth (maternal effect); LUSC cis rs4853012 0.887 rs7570950 chr2:74338942 T/C cg05776053 chr2:74358815 NA 0.39 5.88 0.31 1.02e-8 Gestational age at birth (maternal effect); LUSC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg20276088 chr3:133502917 NA -0.43 -6.47 -0.33 3.51e-10 Iron status biomarkers; LUSC cis rs7759001 0.857 rs10946913 chr6:27369873 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC trans rs1814175 0.817 rs10128730 chr11:50023369 G/T cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg12311346 chr5:56204834 C5orf35 -0.97 -13.98 -0.61 2.89e-35 Initial pursuit acceleration; LUSC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7614311 0.636 rs66490742 chr3:63913653 G/A cg22134162 chr3:63841271 THOC7 -0.5 -6.02 -0.31 4.47e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs3806843 0.576 rs246059 chr5:140325010 G/T cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs72634258 0.796 rs4369247 chr1:8168993 C/T cg00042356 chr1:8021962 PARK7 -0.54 -6.66 -0.34 1.15e-10 Inflammatory bowel disease; LUSC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg21573476 chr21:45109991 RRP1B -0.4 -6.42 -0.33 4.74e-10 Mean corpuscular volume; LUSC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg03351412 chr1:154909251 PMVK 0.55 8.7 0.43 1.52e-16 Prostate cancer; LUSC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg01579765 chr21:45077557 HSF2BP -0.52 -10.87 -0.51 9.44e-24 Mean corpuscular volume; LUSC cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg23711669 chr6:146136114 FBXO30 0.87 16.0 0.66 3.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg05347473 chr6:146136440 FBXO30 0.53 9.17 0.45 4.95e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs6845621 0.745 rs6449426 chr4:18865678 A/C cg12196642 chr4:18937545 NA -0.32 -5.86 -0.31 1.1e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs12995491 0.933 rs34366691 chr2:88537451 G/A cg18302933 chr2:88491318 NA -0.34 -6.53 -0.34 2.39e-10 Response to metformin (IC50); LUSC cis rs7523050 0.730 rs41279678 chr1:109440215 G/A cg08274380 chr1:109419600 GPSM2 1.13 11.51 0.53 4.76e-26 Fat distribution (HIV); LUSC cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg13010199 chr12:38710504 ALG10B 0.67 10.38 0.49 4.53e-22 Drug-induced liver injury (flucloxacillin); LUSC trans rs6600671 1.000 rs1832558 chr1:121177380 A/G cg08727972 chr1:148025634 NBPF14 0.46 6.3 0.33 9.5e-10 Hip geometry; LUSC cis rs2227930 0.506 rs9836038 chr3:142130492 C/A cg16271453 chr3:142027066 XRN1 -0.55 -9.75 -0.47 6.18e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs4363385 0.747 rs2879488 chr1:152975241 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg23172400 chr8:95962367 TP53INP1 -0.4 -8.09 -0.4 1.14e-14 Type 2 diabetes; LUSC cis rs6484504 0.576 rs208083 chr11:31196880 C/T cg06552810 chr11:31128660 NA -0.41 -7.14 -0.36 5.8e-12 Red blood cell count; LUSC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs6430585 0.528 rs309151 chr2:136661150 C/T cg07169764 chr2:136633963 MCM6 1.15 17.85 0.7 1.57e-50 Corneal structure; LUSC cis rs17401966 0.964 rs2027331 chr1:10276718 C/T cg19773385 chr1:10388646 KIF1B -0.53 -8.23 -0.41 4.11e-15 Hepatocellular carcinoma; LUSC cis rs738322 0.511 rs5756947 chr22:38573230 G/A cg17652424 chr22:38574118 PLA2G6 -0.3 -5.93 -0.31 7.56e-9 Cutaneous nevi; LUSC cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg05347473 chr6:146136440 FBXO30 0.46 7.89 0.4 4.48e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs870825 0.929 rs870822 chr4:185588200 C/T cg04058563 chr4:185651563 MLF1IP 0.81 11.07 0.52 1.81e-24 Blood protein levels; LUSC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg03289416 chr15:75166202 SCAMP2 0.44 6.93 0.35 2.21e-11 Breast cancer; LUSC cis rs1775715 0.707 rs2799024 chr10:32166922 A/G cg18675610 chr10:32216311 ARHGAP12 0.31 6.67 0.34 1.06e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11711311 1.000 rs4362695 chr3:113534856 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.94 0.35 2.09e-11 IgG glycosylation; LUSC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg17948913 chr5:572064 NA 0.33 5.68 0.3 2.97e-8 Obesity-related traits; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg10351095 chr21:47802916 PCNT 0.43 6.12 0.32 2.64e-9 Testicular germ cell tumor; LUSC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg24675658 chr1:53192096 ZYG11B -0.6 -9.02 -0.44 1.52e-17 Monocyte count; LUSC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg06636001 chr8:8085503 FLJ10661 -0.63 -10.09 -0.48 4.53e-21 Joint mobility (Beighton score); LUSC cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs668210 0.739 rs543952 chr11:65744275 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.58 7.55 0.38 4.17e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs8077889 0.871 rs17675370 chr17:41900030 T/C cg26893861 chr17:41843967 DUSP3 0.96 14.79 0.63 1.94e-38 Triglycerides; LUSC cis rs7808935 0.914 rs10807843 chr7:27992390 T/C cg22168087 chr7:27702803 HIBADH 0.54 6.45 0.33 3.91e-10 Prostate cancer; LUSC cis rs4363385 0.818 rs546666 chr1:153015385 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -5.79 -0.3 1.62e-8 Inflammatory skin disease; LUSC cis rs1014246 1.000 rs2240705 chr10:118467334 C/T cg14919929 chr10:118506882 NA 0.38 5.88 0.31 9.98e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg26769984 chr7:1090371 C7orf50 -0.7 -10.34 -0.49 6.39e-22 Bronchopulmonary dysplasia; LUSC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg26924012 chr15:45694286 SPATA5L1 1.13 20.65 0.75 1.23e-61 Homoarginine levels; LUSC cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg26384229 chr12:38710491 ALG10B 0.89 14.82 0.63 1.52e-38 Bladder cancer; LUSC cis rs7904985 0.813 rs1077092 chr10:88101391 G/A cg07322936 chr10:88137208 NA -0.56 -7.29 -0.37 2.32e-12 Barrett's esophagus; LUSC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg00310523 chr12:86230176 RASSF9 0.45 8.31 0.41 2.43e-15 Major depressive disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19357178 chr21:45527350 PWP2 0.45 6.45 0.33 4.02e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6788232 0.822 rs9884065 chr3:138736641 T/C cg05026658 chr7:102918083 DPY19L2P2 -0.54 -5.97 -0.31 6.14e-9 Male-pattern baldness; LUSC cis rs7267979 1.000 rs397119 chr20:25440187 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.09 0.74 2.07e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg19046167 chr17:80928561 B3GNTL1 -0.38 -6.27 -0.32 1.12e-9 Breast cancer; LUSC cis rs6681460 1.000 rs2872078 chr1:67127367 C/A cg02459107 chr1:67143332 SGIP1 0.48 8.97 0.44 2.14e-17 Presence of antiphospholipid antibodies; LUSC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg05855489 chr10:104503620 C10orf26 0.63 8.2 0.41 5.12e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg24531977 chr5:56204891 C5orf35 -1.02 -15.17 -0.64 6.53e-40 Initial pursuit acceleration; LUSC cis rs11971779 0.618 rs10085814 chr7:139064089 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs11885103 0.746 rs2685242 chr2:595125 A/C cg21195176 chr2:593345 NA 0.3 5.74 0.3 2.1e-8 Heschl's gyrus morphology; LUSC cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.5 0.56 1.12e-29 Motion sickness; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.93 0.4 3.25e-14 Prudent dietary pattern; LUSC cis rs9611565 0.525 rs9611549 chr22:41705909 C/G cg03806693 chr22:41940476 POLR3H -0.63 -9.25 -0.45 2.67e-18 Vitiligo; LUSC cis rs4704187 0.687 rs1477934 chr5:74423243 A/T cg03227963 chr5:74354835 NA 0.32 6.77 0.35 5.68e-11 Response to amphetamines; LUSC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg21433313 chr16:3507492 NAT15 0.68 11.32 0.53 2.34e-25 Tuberculosis; LUSC cis rs68170813 0.559 rs1548524 chr7:106944563 G/T cg02696742 chr7:106810147 HBP1 0.62 9.5 0.46 4.31e-19 Coronary artery disease; LUSC cis rs7927771 0.524 rs4752865 chr11:47759841 G/A cg20307385 chr11:47447363 PSMC3 -0.44 -6.61 -0.34 1.51e-10 Subjective well-being; LUSC cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg18225595 chr11:63971243 STIP1 0.42 6.84 0.35 3.71e-11 Platelet count; LUSC cis rs4243830 0.850 rs7540913 chr1:6581877 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -9.59 -0.46 2.14e-19 Body mass index; LUSC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg22467129 chr15:76604101 ETFA -0.43 -6.85 -0.35 3.54e-11 Blood metabolite levels; LUSC cis rs11048434 0.761 rs10842660 chr12:9138897 G/A cg13575925 chr12:9217583 LOC144571 0.34 6.31 0.33 8.69e-10 Sjögren's syndrome; LUSC cis rs1801251 1.000 rs6437074 chr2:233712296 C/T cg08000102 chr2:233561755 GIGYF2 -0.64 -10.28 -0.49 1.04e-21 Coronary artery disease; LUSC cis rs9303401 0.592 rs12936771 chr17:56725052 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.61 0.6 7.09e-34 Cognitive test performance; LUSC cis rs2273669 0.588 rs12201102 chr6:109317388 A/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs6442522 1.000 rs6442522 chr3:15440556 C/T cg16303742 chr3:15540471 COLQ 0.28 5.67 0.3 3.07e-8 Uric acid levels; LUSC trans rs2018683 0.707 rs4722875 chr7:28969632 A/G cg19402173 chr7:128379420 CALU -0.46 -6.92 -0.35 2.35e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs4604732 0.631 rs74154675 chr1:247625836 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9815354 0.951 rs73830511 chr3:41864643 G/T cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.6e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs1160297 0.576 rs1376570 chr2:53087099 G/A cg07782112 chr2:53107842 NA 0.37 6.13 0.32 2.51e-9 Hemostatic factors and hematological phenotypes; LUSC trans rs7618501 0.633 rs2856234 chr3:50139142 A/G cg21659725 chr3:3221576 CRBN -0.62 -10.13 -0.48 3.24e-21 Intelligence (multi-trait analysis); LUSC cis rs7264396 0.676 rs6058380 chr20:34552900 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg14983838 chr19:29218262 NA 0.65 9.14 0.45 6.14e-18 Methadone dose in opioid dependence; LUSC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg27165867 chr14:105738592 BRF1 -0.5 -6.98 -0.36 1.6e-11 Mean platelet volume;Platelet distribution width; LUSC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg03233332 chr7:66118400 NA -0.4 -5.92 -0.31 8.15e-9 Aortic root size; LUSC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg07701084 chr6:150067640 NUP43 0.53 7.99 0.4 2.25e-14 Lung cancer; LUSC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg10253484 chr15:75165896 SCAMP2 -0.46 -6.5 -0.34 2.96e-10 Breast cancer; LUSC cis rs7524258 0.900 rs1476047 chr1:7312172 C/T cg07173049 chr1:7289937 CAMTA1 0.3 6.11 0.32 2.85e-9 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs56804039 1.000 rs67180327 chr8:8380754 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -6.27 -0.32 1.12e-9 Cervical cancer; LUSC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg25019033 chr10:957182 NA -0.51 -6.43 -0.33 4.5e-10 Eosinophil percentage of granulocytes; LUSC cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg24558204 chr6:135376177 HBS1L 0.68 10.82 0.51 1.32e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs10740039 0.842 rs10761537 chr10:62409021 C/G cg18175470 chr10:62150864 ANK3 -0.47 -6.96 -0.36 1.77e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11758351 1.000 rs80259160 chr6:26190199 C/T cg11342453 chr6:26196699 NA 0.54 5.71 0.3 2.52e-8 Gout;Renal underexcretion gout; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26832062 chr1:54303852 TMEM48 0.47 6.57 0.34 1.93e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6489882 0.867 rs4766673 chr12:113365161 C/T cg20102336 chr12:113376681 OAS3 0.4 5.84 0.3 1.22e-8 Chronic lymphocytic leukemia; LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg14004847 chr7:1930337 MAD1L1 -0.51 -7.84 -0.39 6.14e-14 Bipolar disorder and schizophrenia; LUSC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg11812906 chr14:75593930 NEK9 0.63 10.55 0.5 1.22e-22 Height; LUSC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7674212 0.541 rs2720471 chr4:104023840 A/G cg16532752 chr4:104119610 CENPE -0.51 -7.38 -0.37 1.23e-12 Type 2 diabetes; LUSC cis rs3820068 0.562 rs10927841 chr1:16045261 T/C cg13390004 chr1:15929781 NA 0.42 6.64 0.34 1.25e-10 Systolic blood pressure; LUSC cis rs6684514 1.000 rs10494304 chr1:156285764 C/G cg16558208 chr1:156270281 VHLL -0.35 -5.85 -0.31 1.14e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs2580764 0.541 rs2968786 chr2:55264859 C/G cg20993754 chr2:55226987 RTN4 -0.39 -6.47 -0.33 3.48e-10 Mean platelet volume; LUSC cis rs6076065 0.723 rs2253925 chr20:23388021 C/G cg11657817 chr20:23433608 CST11 0.42 7.98 0.4 2.32e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs4076764 0.522 rs4265409 chr1:163414559 C/T cg24596788 chr1:163392923 NA -0.37 -6.66 -0.34 1.16e-10 Motion sickness; LUSC cis rs9517320 0.534 rs61969451 chr13:99167654 A/T cg07423050 chr13:99094983 FARP1 -0.56 -10.55 -0.5 1.17e-22 Longevity; LUSC cis rs4803468 1.000 rs10409485 chr19:41920765 C/T cg09537434 chr19:41945824 ATP5SL 0.85 14.78 0.63 2.29e-38 Height; LUSC cis rs9303280 0.870 rs6503524 chr17:38069809 C/T cg10909506 chr17:38081995 ORMDL3 -0.35 -6.28 -0.33 1.04e-9 Self-reported allergy; LUSC cis rs5770917 1.000 rs762677 chr22:51017713 G/A cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.58 -5.65 -0.3 3.42e-8 Narcolepsy; LUSC cis rs17125944 0.505 rs77433996 chr14:53212263 G/A cg13660082 chr14:53194042 PSMC6 -0.75 -6.77 -0.35 5.9e-11 Alzheimer's disease (late onset); LUSC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg04155289 chr7:94953770 PON1 -0.33 -5.69 -0.3 2.78e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1801251 1.000 rs6724117 chr2:233593660 T/G cg08000102 chr2:233561755 GIGYF2 0.68 11.39 0.53 1.31e-25 Coronary artery disease; LUSC cis rs12541635 1.000 rs7817197 chr8:107089633 T/G cg10147462 chr8:107024639 NA -0.48 -8.76 -0.43 1.03e-16 Age of smoking initiation; LUSC cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.19 0.37 4.19e-12 Motion sickness; LUSC cis rs6489785 0.710 rs2393717 chr12:121220375 G/C cg02403541 chr12:121454288 C12orf43 0.39 5.75 0.3 1.99e-8 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg22963979 chr7:1858916 MAD1L1 -0.59 -8.9 -0.44 3.5e-17 Bipolar disorder and schizophrenia; LUSC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg11247378 chr22:39784982 NA -0.63 -11.43 -0.53 9.26e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 2.94e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7180079 0.502 rs6494466 chr15:64508763 A/G cg08069370 chr15:64387884 SNX1 0.44 6.52 0.34 2.6e-10 Monocyte count; LUSC cis rs240764 0.781 rs239227 chr6:101107089 C/G cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs1461503 0.932 rs7944492 chr11:122838745 G/T cg27398637 chr11:122830231 C11orf63 -0.42 -6.71 -0.34 8.41e-11 Menarche (age at onset); LUSC cis rs467650 0.509 rs2591443 chr5:97997489 C/T cg03885343 chr5:98108198 RGMB 0.32 5.79 0.3 1.64e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg14668632 chr7:2872130 GNA12 -0.45 -6.83 -0.35 4.03e-11 Height; LUSC cis rs2115630 1.000 rs58581703 chr15:85276935 C/T cg09876464 chr15:85330779 ZNF592 0.37 6.76 0.35 6.14e-11 P wave terminal force; LUSC cis rs11190604 1.000 rs11190607 chr10:102303614 C/T cg07080220 chr10:102295463 HIF1AN 0.7 9.3 0.45 1.88e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg15649852 chr7:65879115 NA -0.4 -5.7 -0.3 2.65e-8 Aortic root size; LUSC trans rs62103177 0.714 rs7227962 chr18:77603283 T/G cg14227996 chr4:17616232 MED28 0.53 5.97 0.31 6.16e-9 Opioid sensitivity; LUSC cis rs6942756 0.659 rs624118 chr7:129096653 C/T cg02491457 chr7:128862824 NA -0.41 -5.67 -0.3 3.05e-8 White matter hyperintensity burden; LUSC cis rs6565180 0.962 rs35480350 chr16:30366039 G/A cg17640201 chr16:30407289 ZNF48 -0.86 -14.11 -0.61 9.08e-36 Tonsillectomy; LUSC cis rs477692 0.699 rs471390 chr10:131382825 A/G cg26102564 chr10:131424627 MGMT -0.38 -5.92 -0.31 8.19e-9 Response to temozolomide; LUSC cis rs12986413 0.651 rs2238612 chr19:2149694 C/T cg09261902 chr19:2140048 AP3D1 -0.34 -6.04 -0.31 4.08e-9 Height; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg00431813 chr7:1051703 C7orf50 -0.38 -5.87 -0.31 1.08e-8 Longevity;Endometriosis; LUSC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC trans rs62238980 0.614 rs76010922 chr22:32471678 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs10736390 0.640 rs10888858 chr1:55108978 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.66 -12.29 -0.56 6.83e-29 Survival in pancreatic cancer; LUSC cis rs11123610 0.679 rs34705357 chr2:3716032 C/T cg19052272 chr2:3704530 ALLC -0.38 -6.72 -0.34 8.09e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12893668 0.637 rs12892038 chr14:104068629 G/A cg04998671 chr14:104000505 TRMT61A -0.42 -6.12 -0.32 2.63e-9 Reticulocyte count; LUSC cis rs9463078 0.547 rs4714819 chr6:44735285 G/C cg25276700 chr6:44698697 NA 0.3 6.18 0.32 1.88e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.6 0.34 1.66e-10 Lung cancer; LUSC cis rs111706465 1 rs111706465 chr2:239452382 A/C cg18131467 chr2:239335373 ASB1 -0.61 -5.66 -0.3 3.28e-8 Morning vs. evening chronotype; LUSC cis rs6696846 0.749 rs6692170 chr1:205074019 G/A cg21643547 chr1:205240462 TMCC2 -0.37 -7.0 -0.36 1.38e-11 Red blood cell count; LUSC cis rs7666738 0.546 rs28444809 chr4:98916934 C/T cg03676636 chr4:99064102 C4orf37 0.3 6.12 0.32 2.57e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg20573242 chr4:122745356 CCNA2 0.65 9.55 0.46 2.9e-19 Type 2 diabetes; LUSC cis rs72634258 0.786 rs7539807 chr1:8183789 C/T cg26816564 chr1:7831052 VAMP3 0.46 5.88 0.31 9.82e-9 Inflammatory bowel disease; LUSC cis rs868036 0.718 rs16951275 chr15:68077168 T/C cg24579218 chr15:68104479 NA -0.36 -6.45 -0.33 4.01e-10 Restless legs syndrome; LUSC cis rs35883536 0.669 rs1932352 chr1:101161251 G/A cg06223162 chr1:101003688 GPR88 -0.44 -7.68 -0.39 1.73e-13 Monocyte count; LUSC cis rs6460942 0.908 rs78780802 chr7:12233216 T/C cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs58749629 1.000 rs73128528 chr20:44582187 A/T cg10662479 chr20:44420225 WFDC3;DNTTIP1 -0.63 -5.96 -0.31 6.28e-9 Abdominal aortic aneurysm; LUSC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg15147215 chr3:52552868 STAB1 -0.29 -5.74 -0.3 2.08e-8 Electroencephalogram traits; LUSC cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg17971929 chr21:40555470 PSMG1 -0.51 -7.54 -0.38 4.47e-13 Menarche (age at onset); LUSC cis rs6121246 0.529 rs6060174 chr20:30183538 G/A cg13852791 chr20:30311386 BCL2L1 0.74 8.32 0.41 2.2e-15 Mean corpuscular hemoglobin; LUSC cis rs977987 0.933 rs4888431 chr16:75500699 G/T cg03315344 chr16:75512273 CHST6 0.55 10.7 0.51 3.58e-23 Dupuytren's disease; LUSC cis rs16867321 1.000 rs1358521 chr2:181444628 T/C cg23363182 chr2:181467187 NA -0.43 -5.91 -0.31 8.31e-9 Obesity; LUSC trans rs10838798 0.504 rs11039673 chr11:48335156 G/A cg21153622 chr11:89784906 NA -0.39 -5.98 -0.31 5.61e-9 Height; LUSC cis rs3845702 0.668 rs3856415 chr2:180807367 G/A cg01881094 chr2:180872142 CWC22 -1.07 -12.55 -0.57 7.17e-30 Schizophrenia; LUSC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg14584255 chr6:163149320 PACRG;PARK2 -0.39 -7.63 -0.39 2.46e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11971779 0.680 rs6946393 chr7:139106169 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7824557 0.564 rs7834572 chr8:11236685 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.19e-14 Retinal vascular caliber; LUSC cis rs8017423 0.935 rs8012303 chr14:90715829 G/A cg14092571 chr14:90743983 NA -0.36 -5.9 -0.31 8.93e-9 Mortality in heart failure; LUSC cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.27 0.56 7.85e-29 Motion sickness; LUSC trans rs2898290 0.622 rs1478890 chr8:11355602 C/G cg15556689 chr8:8085844 FLJ10661 -0.52 -8.07 -0.4 1.29e-14 Systolic blood pressure; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg24813613 chr7:1882135 MAD1L1 -0.36 -5.8 -0.3 1.56e-8 Bipolar disorder and schizophrenia; LUSC cis rs6964587 0.967 rs10246036 chr7:91558523 G/A cg22709100 chr7:91322751 NA -0.4 -5.76 -0.3 1.9e-8 Breast cancer; LUSC cis rs354225 0.512 rs9917248 chr2:54924463 C/T cg26097391 chr2:54893211 SPTBN1 0.44 5.89 0.31 9.53e-9 Schizophrenia; LUSC cis rs6712932 1.000 rs6746579 chr2:105843223 G/T cg26874229 chr2:105853672 NA -0.32 -5.7 -0.3 2.57e-8 Type 2 diabetes; LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.11 0.61 8.77e-36 Platelet count; LUSC cis rs7267979 0.528 rs2387976 chr20:25599560 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.64 -0.57 3.25e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Melanoma; LUSC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg06484146 chr7:12443880 VWDE 0.64 7.85 0.39 5.75e-14 Coronary artery disease; LUSC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs4589502 1.000 rs7170743 chr15:67126339 T/G cg09911534 chr15:67153556 NA -0.66 -6.66 -0.34 1.14e-10 Lung cancer (smoking interaction); LUSC cis rs6977660 0.652 rs10275246 chr7:19851059 G/A cg05791153 chr7:19748676 TWISTNB 0.59 5.79 0.3 1.6e-8 Thyroid stimulating hormone; LUSC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg04944784 chr2:26401820 FAM59B -0.7 -9.96 -0.48 1.27e-20 Gut microbiome composition (summer); LUSC cis rs1784581 0.721 rs9365356 chr6:162414789 A/G cg17173639 chr6:162384350 PARK2 0.66 11.84 0.54 3.02e-27 Itch intensity from mosquito bite; LUSC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg20283391 chr11:68216788 NA 0.55 8.39 0.42 1.39e-15 Total body bone mineral density; LUSC cis rs16917546 0.935 rs10822050 chr10:64438771 T/C cg03961010 chr10:64397487 ZNF365 -0.39 -6.12 -0.32 2.65e-9 Basal cell carcinoma; LUSC cis rs79839061 0.610 rs2306252 chr4:892116 T/C cg07828340 chr4:882639 GAK 0.84 9.57 0.46 2.52e-19 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.31 -0.41 2.42e-15 Gut microbiome composition (summer); LUSC trans rs7615952 0.558 rs17334039 chr3:125540308 A/G cg07211511 chr3:129823064 LOC729375 -0.99 -13.72 -0.6 2.82e-34 Blood pressure (smoking interaction); LUSC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg18451016 chr1:38461880 NA -0.58 -10.25 -0.49 1.32e-21 Coronary artery disease; LUSC cis rs3007168 1.000 rs3007075 chr14:51604860 A/G cg23942311 chr14:51606299 NA 0.36 6.07 0.32 3.5e-9 Cancer; LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg14668632 chr7:2872130 GNA12 -0.41 -6.05 -0.31 3.93e-9 Height; LUSC cis rs4704187 0.553 rs116188801 chr5:74398141 A/G cg03227963 chr5:74354835 NA 0.32 6.87 0.35 3.09e-11 Response to amphetamines; LUSC cis rs6456156 0.774 rs6456158 chr6:167528032 A/C cg07741184 chr6:167504864 NA 0.36 6.31 0.33 8.7e-10 Primary biliary cholangitis; LUSC cis rs8062405 0.964 rs11860513 chr16:28825420 C/T cg09754948 chr16:28834200 ATXN2L 0.44 6.47 0.33 3.56e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.91 0.4 3.88e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs977987 0.806 rs12444589 chr16:75454404 A/T cg04384234 chr16:75411784 CFDP1 0.43 7.01 0.36 1.35e-11 Dupuytren's disease; LUSC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg03351412 chr1:154909251 PMVK 0.55 8.85 0.44 5.3e-17 Prostate cancer; LUSC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg22903471 chr2:27725779 GCKR -0.41 -7.06 -0.36 9.43e-12 Total body bone mineral density; LUSC cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg03647239 chr10:116582469 FAM160B1 0.47 7.51 0.38 5.45e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg01884057 chr2:25150051 NA 0.48 11.39 0.53 1.29e-25 Body mass index; LUSC cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.15 -0.45 5.74e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs372883 0.935 rs1153294 chr21:30701096 A/G cg08807101 chr21:30365312 RNF160 -0.44 -6.35 -0.33 7.04e-10 Pancreatic cancer; LUSC cis rs3772130 0.962 rs9878086 chr3:121488353 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.17 0.49 2.48e-21 Cognitive performance; LUSC cis rs7681440 0.904 rs28750169 chr4:90774303 A/G cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.3 1.18e-8 Dementia with Lewy bodies; LUSC cis rs9640161 0.830 rs11972067 chr7:150071605 G/A cg27494647 chr7:150038898 RARRES2 0.36 5.8 0.3 1.52e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9527 1.000 rs4919690 chr10:104616500 C/T cg15744005 chr10:104629667 AS3MT 0.35 6.75 0.35 6.64e-11 Arsenic metabolism; LUSC cis rs2742417 1.000 rs2742435 chr3:45740863 C/T cg09608765 chr3:45636137 LIMD1 -0.35 -6.44 -0.33 4.11e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6546550 0.935 rs1531025 chr2:70055505 G/T cg02498382 chr2:70120550 SNRNP27 -0.26 -5.94 -0.31 7.16e-9 Prevalent atrial fibrillation; LUSC cis rs9549367 0.713 rs2476319 chr13:113836519 C/T cg18105134 chr13:113819100 PROZ 0.66 9.91 0.48 1.79e-20 Platelet distribution width; LUSC trans rs1459104 0.866 rs12787024 chr11:54883667 C/T cg15704280 chr7:45808275 SEPT13 0.71 6.34 0.33 7.62e-10 Body mass index; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg07920855 chr1:185286635 IVNS1ABP -0.5 -7.38 -0.37 1.3e-12 Cognitive function;Information processing speed; LUSC cis rs936229 0.749 rs6495126 chr15:75175026 C/T cg14664628 chr15:75095509 CSK 0.81 12.47 0.56 1.4e-29 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs6456156 0.586 rs12529876 chr6:167461501 G/A cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs262147 1.000 rs262147 chr7:158745142 A/G cg11984989 chr7:158649758 WDR60 0.64 5.89 0.31 9.3e-9 Hippocampal volume; LUSC cis rs12541635 0.677 rs1603357 chr8:107000565 G/C cg10147462 chr8:107024639 NA 0.67 14.03 0.61 1.7000000000000001e-35 Age of smoking initiation; LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs11809207 0.857 rs11247866 chr1:26517794 A/G cg00300879 chr1:26503847 CNKSR1 0.29 5.67 0.3 3.14e-8 Height; LUSC cis rs62027291 0.950 rs55747356 chr15:77284813 C/T cg26408565 chr15:76604113 ETFA 0.49 6.09 0.32 3.13e-9 Plateletcrit; LUSC cis rs6845621 0.870 rs6449437 chr4:18918825 C/G cg12196642 chr4:18937545 NA -0.34 -6.38 -0.33 5.8e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs977987 0.806 rs4638613 chr16:75425553 C/T cg03315344 chr16:75512273 CHST6 0.52 10.03 0.48 7.24e-21 Dupuytren's disease; LUSC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC cis rs7772486 0.902 rs2777480 chr6:146309983 T/A cg23711669 chr6:146136114 FBXO30 0.77 13.29 0.59 1.17e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg21573476 chr21:45109991 RRP1B -0.43 -6.81 -0.35 4.63e-11 Mean corpuscular volume; LUSC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg21770322 chr7:97807741 LMTK2 0.41 7.03 0.36 1.14e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg16414030 chr3:133502952 NA -0.52 -8.33 -0.41 2.1e-15 Iron status biomarkers; LUSC cis rs1805008 0.535 rs7196459 chr16:90141477 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.86 -6.59 -0.34 1.68e-10 Skin colour saturation; LUSC cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg16339924 chr4:17578868 LAP3 0.64 10.11 0.48 3.72e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.5 7.85 0.39 5.67e-14 Cognitive test performance; LUSC cis rs559928 0.606 rs55942618 chr11:63936005 C/T cg05555928 chr11:63887634 MACROD1 -0.49 -6.05 -0.31 3.95e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2732480 0.577 rs2634693 chr12:48706498 C/T cg21466736 chr12:48725269 NA -0.33 -5.74 -0.3 2.16e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs8072100 0.701 rs4794053 chr17:45769551 G/A cg04995722 chr7:26192034 NFE2L3 -0.42 -6.46 -0.33 3.79e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg12927641 chr6:109611667 NA -0.34 -5.8 -0.3 1.52e-8 Reticulocyte fraction of red cells; LUSC cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg21963583 chr11:68658836 MRPL21 0.57 8.8 0.43 7.33e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg11845111 chr2:191398756 TMEM194B -0.55 -9.49 -0.46 4.63e-19 Pulse pressure; LUSC cis rs6121246 0.647 rs6088855 chr20:30225792 C/T cg13852791 chr20:30311386 BCL2L1 0.87 10.61 0.5 7.15e-23 Mean corpuscular hemoglobin; LUSC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg18252515 chr7:66147081 NA -1.2 -13.78 -0.6 1.67e-34 Diabetic kidney disease; LUSC cis rs13256369 0.853 rs13256216 chr8:8577883 C/T cg06671706 chr8:8559999 CLDN23 0.49 6.33 0.33 8.06e-10 Obesity-related traits; LUSC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.8e-10 Schizophrenia; LUSC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg08280861 chr8:58055591 NA 0.52 5.73 0.3 2.21e-8 Developmental language disorder (linguistic errors); LUSC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg01448562 chr3:133502909 NA -0.74 -12.58 -0.57 5.54e-30 Iron status biomarkers; LUSC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs9296092 0.521 rs6929165 chr6:33515958 T/G cg13560919 chr6:33536144 NA -0.72 -13.4 -0.59 4.63e-33 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs10207060 0.500 rs10177457 chr2:240708067 G/A cg07506560 chr2:240697449 NA 0.44 6.86 0.35 3.26e-11 Obesity-related traits; LUSC cis rs2797685 1.000 rs2797685 chr1:7879063 C/T cg04725166 chr1:7887271 PER3 -0.46 -6.45 -0.33 3.86e-10 Crohn's disease; LUSC cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg13319975 chr6:146136371 FBXO30 -0.53 -7.96 -0.4 2.78e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs939658 1.000 rs8027411 chr15:79461029 G/T cg17916960 chr15:79447300 NA 0.5 9.95 0.48 1.33e-20 Refractive error; LUSC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg27572855 chr1:25598939 RHD -0.41 -7.1 -0.36 7.61e-12 Erythrocyte sedimentation rate; LUSC cis rs7582180 0.614 rs2241809 chr2:101014363 C/T cg12002119 chr2:101014098 CHST10 0.35 5.75 0.3 2.05e-8 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.752 rs7623567 chr3:134330976 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs79976124 0.876 rs17511913 chr6:66644361 C/T cg07460842 chr6:66804631 NA 0.7 8.78 0.43 8.43e-17 Type 2 diabetes; LUSC cis rs7474896 0.609 rs11011336 chr10:37985316 A/G cg25427524 chr10:38739819 LOC399744 -0.49 -6.54 -0.34 2.28e-10 Obesity (extreme); LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -11.87 -0.54 2.4200000000000002e-27 Platelet count; LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14240646 chr10:27532245 ACBD5 -0.74 -8.14 -0.41 8.13e-15 Breast cancer; LUSC cis rs10761482 0.500 rs1892547 chr10:62292958 G/A cg18175470 chr10:62150864 ANK3 -0.47 -6.84 -0.35 3.86e-11 Schizophrenia; LUSC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg12311346 chr5:56204834 C5orf35 0.64 9.28 0.45 2.23e-18 Coronary artery disease; LUSC cis rs9311676 0.656 rs11130635 chr3:58379143 A/G cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg19352682 chr22:24059718 LOC91316 -0.46 -6.12 -0.32 2.66e-9 Hepatitis; LUSC cis rs739496 0.947 rs10849949 chr12:111893537 C/T cg10833066 chr12:111807467 FAM109A -0.31 -5.7 -0.3 2.62e-8 Platelet count; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg17607973 chr7:100027408 MEPCE;ZCWPW1 0.43 7.0 0.36 1.45e-11 Triglycerides; LUSC cis rs3771570 1.000 rs17386695 chr2:242379751 A/G cg21155796 chr2:242212141 HDLBP -0.62 -6.74 -0.35 6.8e-11 Prostate cancer; LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg22920501 chr2:26401640 FAM59B 0.83 11.99 0.55 8.76e-28 Gut microbiome composition (summer); LUSC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg06008330 chr7:65541103 ASL -0.4 -6.3 -0.33 9.14e-10 Aortic root size; LUSC cis rs8040855 0.644 rs7495437 chr15:85726290 A/G cg04831495 chr15:85060580 GOLGA6L5 0.4 6.45 0.33 3.86e-10 Bulimia nervosa; LUSC cis rs6547741 0.967 rs4665996 chr2:27814343 T/C cg12559939 chr2:27858050 GPN1 0.41 6.45 0.33 3.94e-10 Oral cavity cancer; LUSC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg17294928 chr15:75287854 SCAMP5 -0.82 -10.91 -0.51 6.64e-24 Blood trace element (Zn levels); LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg11060661 chr22:24314208 DDT;DDTL 0.5 8.15 0.41 7.37e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg16230307 chr14:35515116 FAM177A1 0.49 6.18 0.32 1.84e-9 Psoriasis; LUSC trans rs60843830 0.928 rs62114494 chr2:211317 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 10.3 0.49 8.81e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg04369109 chr6:150039330 LATS1 -0.56 -8.25 -0.41 3.74e-15 Lung cancer; LUSC cis rs10791097 0.694 rs10791100 chr11:130738946 T/A cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9487051 0.737 rs1260593 chr6:109521400 C/T cg00509249 chr6:109615579 CCDC162 -0.33 -5.79 -0.3 1.66e-8 Reticulocyte fraction of red cells; LUSC cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg08754478 chr10:133766260 PPP2R2D -0.62 -8.05 -0.4 1.47e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs12579753 0.879 rs12829053 chr12:82161926 T/A cg07988820 chr12:82153109 PPFIA2 -0.45 -6.68 -0.34 9.94e-11 Resting heart rate; LUSC cis rs7592578 0.723 rs4371384 chr2:191430741 A/G cg11845111 chr2:191398756 TMEM194B 0.87 11.31 0.53 2.42e-25 Diastolic blood pressure; LUSC cis rs72781680 0.898 rs2879640 chr2:24043573 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg25767906 chr1:53392781 SCP2 -0.52 -9.58 -0.46 2.27e-19 Monocyte count; LUSC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg23630131 chr7:65973040 NA 0.2 5.71 0.3 2.54e-8 Aortic root size; LUSC cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.77 0.3 1.84e-8 Rheumatoid arthritis; LUSC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.96 -0.36 1.78e-11 Menopause (age at onset); LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg07167872 chr1:205819463 PM20D1 -0.84 -16.1 -0.66 1.39e-43 Menarche (age at onset); LUSC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg00074818 chr8:8560427 CLDN23 -0.46 -7.5 -0.38 5.65e-13 Obesity-related traits; LUSC trans rs11098499 0.954 rs9993199 chr4:120392873 A/G cg25214090 chr10:38739885 LOC399744 -0.56 -8.35 -0.42 1.85e-15 Corneal astigmatism; LUSC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg16447950 chr5:562315 NA -0.55 -6.71 -0.34 8.15e-11 Obesity-related traits; LUSC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg23625390 chr15:77176239 SCAPER 0.46 7.0 0.36 1.44e-11 Blood metabolite levels; LUSC cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg06028605 chr16:24865363 SLC5A11 0.48 8.42 0.42 1.13e-15 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg18904891 chr8:8559673 CLDN23 -0.38 -5.74 -0.3 2.17e-8 Mood instability; LUSC cis rs10463316 0.817 rs1810083 chr5:150776807 A/G cg03212797 chr5:150827313 SLC36A1 0.44 6.74 0.35 6.98e-11 Metabolite levels (Pyroglutamine); LUSC cis rs4631830 0.863 rs2926494 chr10:51517356 T/C cg20129853 chr10:51489980 NA -0.32 -6.35 -0.33 6.97e-10 Prostate-specific antigen levels; LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg05313129 chr8:58192883 C8orf71 -0.53 -5.96 -0.31 6.55e-9 Developmental language disorder (linguistic errors); LUSC trans rs9329221 0.521 rs4841294 chr8:10105068 G/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.39 -0.37 1.19e-12 Neuroticism; LUSC cis rs365132 0.875 rs2454952 chr5:176376493 C/T cg25401027 chr5:176370377 UIMC1 0.35 5.76 0.3 1.94e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg18404041 chr3:52824283 ITIH1 -0.61 -12.03 -0.55 6.09e-28 Bipolar disorder; LUSC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg08499158 chr17:42289980 UBTF 0.41 6.3 0.33 9.56e-10 Total body bone mineral density; LUSC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7524258 0.868 rs4243825 chr1:7308264 T/C cg07173049 chr1:7289937 CAMTA1 0.34 6.92 0.35 2.37e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7107174 1.000 rs7117238 chr11:78040259 G/A cg02023728 chr11:77925099 USP35 0.42 6.4 0.33 5.32e-10 Testicular germ cell tumor; LUSC cis rs7100689 0.646 rs10749579 chr10:82140959 C/T cg00277334 chr10:82204260 NA -0.5 -7.28 -0.37 2.44e-12 Post bronchodilator FEV1; LUSC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg23283495 chr1:209979779 IRF6 0.73 9.34 0.46 1.37e-18 Cleft lip with or without cleft palate; LUSC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg12257692 chr3:49977190 RBM6 -0.24 -6.42 -0.33 4.77e-10 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg13010199 chr12:38710504 ALG10B 0.66 10.0 0.48 9.42e-21 Bladder cancer; LUSC cis rs1413885 0.516 rs6659883 chr1:65838618 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.48 7.04 0.36 1.1e-11 Anticoagulant levels; LUSC cis rs765787 0.505 rs1648302 chr15:45494238 A/G cg24006582 chr15:45444508 DUOX1 -0.66 -9.64 -0.47 1.48e-19 Uric acid levels; LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg22638593 chr5:131593259 PDLIM4 -0.41 -5.87 -0.31 1.07e-8 Breast cancer; LUSC cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.42 -0.38 9.56e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7106204 0.748 rs7946633 chr11:24237411 C/T ch.11.24196551F chr11:24239977 NA 1.17 14.66 0.63 6.73e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg02574844 chr11:5959923 NA -0.39 -6.06 -0.31 3.64e-9 DNA methylation (variation); LUSC cis rs9660992 0.573 rs1172147 chr1:205225457 G/A cg03948781 chr1:205179583 DSTYK 0.3 5.72 0.3 2.31e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1577917 0.771 rs9450290 chr6:86233397 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 10.74 0.51 2.53e-23 Response to antipsychotic treatment; LUSC trans rs10411161 0.702 rs16983196 chr19:52384779 C/A cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.57 -8.43 -0.42 1.06e-15 Alzheimer's disease; LUSC cis rs727505 0.865 rs17325193 chr7:124648385 A/G cg23710748 chr7:124431027 NA -0.38 -6.58 -0.34 1.79e-10 Lewy body disease; LUSC cis rs73198271 0.960 rs11778970 chr8:8609334 G/C cg01851573 chr8:8652454 MFHAS1 0.6 8.37 0.42 1.6e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11098499 0.644 rs2389880 chr4:120559870 T/A cg09307838 chr4:120376055 NA 0.64 9.56 0.46 2.59e-19 Corneal astigmatism; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.23 -0.41 4.36e-15 Obesity-related traits; LUSC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg21951975 chr1:209979733 IRF6 0.54 7.04 0.36 1.12e-11 Cleft lip with or without cleft palate; LUSC cis rs5997397 0.967 rs5752791 chr22:29153547 A/G cg15103426 chr22:29168792 CCDC117 -0.41 -5.7 -0.3 2.65e-8 Red cell distribution width; LUSC cis rs7937682 1.000 rs9734135 chr11:111536190 G/A cg19812747 chr11:111475976 SIK2 -0.45 -6.23 -0.32 1.38e-9 Primary sclerosing cholangitis; LUSC cis rs9467711 0.659 rs35277236 chr6:26562269 G/T cg09904177 chr6:26538194 HMGN4 -0.77 -6.04 -0.31 4.1e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg16545954 chr1:2118288 C1orf86 0.39 7.43 0.38 9.22e-13 Height; LUSC cis rs8060686 0.641 rs12447931 chr16:68179195 C/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.28 -0.37 2.35e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs2832077 0.689 rs2832055 chr21:30132382 C/G cg24692254 chr21:30365293 RNF160 0.6 7.95 0.4 2.86e-14 Cognitive test performance; LUSC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg25373794 chr1:162760220 HSD17B7 -0.47 -6.73 -0.35 7.32e-11 Breast cancer; LUSC cis rs11630290 0.736 rs72752925 chr15:64146100 C/G cg12036633 chr15:63758958 NA -0.67 -6.94 -0.35 2.06e-11 Iris characteristics; LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg06873352 chr17:61820015 STRADA 0.71 12.72 0.57 1.68e-30 Prudent dietary pattern; LUSC cis rs10986311 0.814 rs7861040 chr9:127044135 G/C cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.38 -5.96 -0.31 6.51e-9 Vitiligo; LUSC cis rs7954584 0.567 rs11043246 chr12:122368944 G/A cg21171335 chr12:122356390 WDR66 0.63 9.42 0.46 7.83e-19 Mean corpuscular volume; LUSC cis rs1034435 0.547 rs743846 chr22:48900819 C/T cg05992904 chr22:48892994 FAM19A5 -0.39 -6.73 -0.35 7.45e-11 Late-onset Alzheimer's disease; LUSC cis rs59698941 0.891 rs59707248 chr5:132267535 C/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg07424592 chr7:64974309 NA -0.63 -5.68 -0.3 2.9e-8 Diabetic kidney disease; LUSC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg11189052 chr15:85197271 WDR73 -0.66 -10.36 -0.49 5.55e-22 P wave terminal force; LUSC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg24829409 chr8:58192753 C8orf71 -0.61 -7.4 -0.38 1.08e-12 Developmental language disorder (linguistic errors); LUSC cis rs12681288 0.676 rs2701913 chr8:999982 A/T cg04851639 chr8:1020857 NA -0.36 -7.51 -0.38 5.3e-13 Schizophrenia; LUSC cis rs17818399 0.749 rs4142759 chr2:46783890 A/G cg21681030 chr2:46777652 RHOQ 0.48 6.89 0.35 2.77e-11 Height; LUSC cis rs208520 0.690 rs1738970 chr6:66809491 T/G cg07460842 chr6:66804631 NA -1.14 -18.05 -0.7 2.59e-51 Exhaled nitric oxide output; LUSC trans rs208520 0.954 rs1468153 chr6:67009054 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 9.12 0.45 7.01e-18 Exhaled nitric oxide output; LUSC cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.32 0.37 1.91e-12 Motion sickness; LUSC cis rs4363385 0.818 rs419721 chr1:153006902 C/T cg00922841 chr1:152955080 SPRR1A -0.4 -7.07 -0.36 9.08e-12 Inflammatory skin disease; LUSC cis rs3772130 0.962 rs28660600 chr3:121482637 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.14 0.49 3.04e-21 Cognitive performance; LUSC cis rs763121 0.853 rs5750626 chr22:38977890 G/C cg14440974 chr22:39074834 NA -0.37 -6.15 -0.32 2.22e-9 Menopause (age at onset); LUSC cis rs10761482 0.859 rs972404 chr10:62095851 G/C cg18175470 chr10:62150864 ANK3 -0.47 -6.88 -0.35 3e-11 Schizophrenia; LUSC trans rs9329221 0.506 rs17689674 chr8:9981854 C/A cg06636001 chr8:8085503 FLJ10661 0.5 7.39 0.37 1.18e-12 Neuroticism; LUSC cis rs2404602 0.692 rs10444858 chr15:76962504 T/C cg22467129 chr15:76604101 ETFA -0.43 -6.8 -0.35 4.87e-11 Blood metabolite levels; LUSC cis rs9911578 0.967 rs2333410 chr17:57137129 G/A cg12560992 chr17:57184187 TRIM37 -0.86 -16.74 -0.68 4.12e-46 Intelligence (multi-trait analysis); LUSC cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg12310025 chr6:25882481 NA -0.5 -9.06 -0.44 1.09e-17 Blood metabolite levels; LUSC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.59 7.92 0.4 3.54e-14 Lung function (FEV1/FVC); LUSC cis rs11112613 0.713 rs11112586 chr12:105939816 C/T cg03607813 chr12:105948248 NA 0.7 9.7 0.47 8.94e-20 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs3733585 0.638 rs28715627 chr4:9958140 T/A cg26043149 chr18:55253948 FECH -0.46 -7.05 -0.36 1.01e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg07148914 chr20:33460835 GGT7 0.55 8.63 0.43 2.54e-16 Height; LUSC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg24642844 chr7:1081250 C7orf50 -0.46 -7.42 -0.38 9.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs923109 0.573 rs1060286 chr1:207250300 G/A cg24040043 chr1:207224982 YOD1 -0.38 -7.52 -0.38 5.22e-13 Left atrial antero-posterior diameter; LUSC cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg07636037 chr3:49044803 WDR6 0.43 6.23 0.32 1.43e-9 Resting heart rate; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg16325326 chr1:53192061 ZYG11B -0.7 -10.72 -0.51 3.06e-23 Monocyte count; LUSC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg02609749 chr16:89786786 C16orf7;ZNF276 0.48 7.82 0.39 6.91e-14 Vitiligo; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.59 9.98 0.48 1.09e-20 Lymphocyte counts; LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.15 -0.36 5.65e-12 Bipolar disorder; LUSC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.8 -0.35 4.73e-11 Lung cancer; LUSC cis rs7178572 0.688 rs12591335 chr15:77774894 A/G cg22256960 chr15:77711686 NA 0.56 8.08 0.4 1.2e-14 Type 2 diabetes; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.89 0.55 2.01e-27 Prudent dietary pattern; LUSC cis rs11971779 0.680 rs6954531 chr7:139054706 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC trans rs6601327 0.613 rs10094989 chr8:9612009 T/C cg15556689 chr8:8085844 FLJ10661 0.49 6.81 0.35 4.46e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs368755101 1 rs368755101 chr2:100762215 AG/A cg22139774 chr2:100720529 AFF3 -0.43 -7.33 -0.37 1.71e-12 Plateletcrit;Red blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08701551 chr17:66287507 ARSG;SLC16A6 0.39 6.54 0.34 2.31e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4474465 0.850 rs11237537 chr11:78248397 C/T cg27205649 chr11:78285834 NARS2 -0.51 -5.98 -0.31 5.76e-9 Alzheimer's disease (survival time); LUSC cis rs614226 1.000 rs616157 chr12:120925795 T/C cg27489772 chr12:121021490 NA -0.52 -6.69 -0.34 9.54e-11 Type 1 diabetes nephropathy; LUSC cis rs2286503 0.752 rs59538378 chr7:22877097 G/A cg11367502 chr7:22862612 TOMM7 0.46 6.0 0.31 5.02e-9 Fibrinogen; LUSC cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg12219531 chr12:120966889 COQ5 0.6 8.06 0.4 1.41e-14 High light scatter reticulocyte count; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.26 0.52 3.72e-25 Alzheimer's disease; LUSC cis rs6076065 0.676 rs6076059 chr20:23336261 C/T cg11657817 chr20:23433608 CST11 0.44 8.35 0.42 1.86e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs1568889 1.000 rs12803716 chr11:28055111 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC cis rs6693567 0.545 rs1566225 chr1:150415990 G/C cg15654264 chr1:150340011 RPRD2 0.44 7.11 0.36 7.28e-12 Migraine; LUSC cis rs2011503 0.882 rs72999030 chr19:19364240 A/T cg11584989 chr19:19387371 SF4 0.61 7.27 0.37 2.54e-12 Bipolar disorder; LUSC cis rs9457247 0.565 rs12193698 chr6:167512073 C/A cg06454157 chr6:167490870 NA -0.25 -5.68 -0.3 2.97e-8 Crohn's disease; LUSC trans rs979233 0.502 rs276237 chr5:42058597 A/G cg07010552 chr17:7358735 CHRNB1 -0.41 -6.03 -0.31 4.43e-9 Systemic lupus erythematosus; LUSC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg27532560 chr4:187881888 NA -0.37 -6.09 -0.32 3.16e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.9 0.35 2.56e-11 Rheumatoid arthritis; LUSC trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg03929089 chr4:120376271 NA 0.82 11.44 0.53 8.71e-26 Coronary artery disease; LUSC cis rs11673344 0.503 rs1667370 chr19:37490220 A/T cg27390819 chr19:37464633 NA -0.34 -5.68 -0.3 2.95e-8 Obesity-related traits; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg12432903 chr7:1882776 MAD1L1 -0.38 -6.01 -0.31 4.88e-9 Bipolar disorder and schizophrenia; LUSC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.07 0.32 3.47e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC trans rs13390641 0.614 rs72932426 chr2:104094304 T/A cg03260781 chr1:16346299 HSPB7 -0.46 -6.09 -0.32 3.14e-9 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg20887711 chr4:1340912 KIAA1530 0.49 7.72 0.39 1.38e-13 Longevity; LUSC cis rs11677370 0.603 rs11696104 chr2:3849512 C/G cg17052675 chr2:3827356 NA -0.63 -10.27 -0.49 1.12e-21 Type 2 diabetes; LUSC cis rs765787 0.530 rs1706832 chr15:45517173 C/T cg24006582 chr15:45444508 DUOX1 -0.61 -9.28 -0.45 2.14e-18 Uric acid levels; LUSC cis rs7119 0.717 rs12901338 chr15:77804900 T/A cg27398640 chr15:77910606 LINGO1 -0.29 -6.18 -0.32 1.89e-9 Type 2 diabetes; LUSC trans rs7556950 0.572 rs60921002 chr2:41929675 C/T cg13792581 chr20:43590115 TOMM34 0.75 6.36 0.33 6.74e-10 Major depression and alcohol dependence; LUSC cis rs17685 0.753 rs6951808 chr7:75772413 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4474465 0.915 rs4944204 chr11:78222013 G/T cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg26384229 chr12:38710491 ALG10B 0.85 13.4 0.59 4.79e-33 Bladder cancer; LUSC trans rs2262909 0.925 rs73019900 chr19:22286680 G/A cg17074339 chr11:11642133 GALNTL4 0.44 6.8 0.35 4.77e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs1493916 0.870 rs8083723 chr18:31384398 C/T cg15819921 chr19:927150 ARID3A -0.43 -6.46 -0.33 3.73e-10 Life satisfaction; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg00149659 chr3:10157352 C3orf10 0.96 13.92 0.61 4.8e-35 Alzheimer's disease; LUSC cis rs12549902 0.800 rs7825494 chr8:41507350 C/T cg21772509 chr8:41503840 NKX6-3 0.67 11.09 0.52 1.5e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs4595586 0.505 rs12823590 chr12:39399750 A/T cg13010199 chr12:38710504 ALG10B 0.4 5.67 0.3 3.14e-8 Morning vs. evening chronotype; LUSC cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg08754478 chr10:133766260 PPP2R2D 0.6 8.15 0.41 7.14e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs4786125 0.512 rs55818804 chr16:6930199 T/C cg03623568 chr16:6915990 A2BP1 -0.48 -7.8 -0.39 7.99e-14 Heart rate variability traits (SDNN); LUSC cis rs4888262 0.526 rs6564142 chr16:74590047 T/C cg01733217 chr16:74700730 RFWD3 0.75 12.29 0.56 6.92e-29 Testicular germ cell tumor; LUSC cis rs281408 0.559 rs281386 chr19:49217305 A/G cg13540341 chr19:49222985 MAMSTR 0.37 6.15 0.32 2.16e-9 Urinary metabolites (H-NMR features); LUSC cis rs7707921 1.000 rs4703879 chr5:81553815 C/T cg15871215 chr5:81402204 ATG10 -0.43 -6.19 -0.32 1.81e-9 Breast cancer; LUSC cis rs2953145 0.617 rs7557192 chr2:241541274 T/C cg07929629 chr2:241523174 NA 0.61 11.07 0.52 1.73e-24 Bipolar disorder; LUSC cis rs4285028 0.747 rs3772126 chr3:121354583 G/A cg11130432 chr3:121712080 ILDR1 -0.58 -8.39 -0.42 1.42e-15 Multiple sclerosis; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg07677032 chr17:61819896 STRADA 0.52 8.61 0.43 2.91e-16 Prudent dietary pattern; LUSC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg19622623 chr12:86230825 RASSF9 0.44 6.38 0.33 5.95e-10 Major depressive disorder; LUSC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg24110177 chr3:50126178 RBM5 -0.55 -8.92 -0.44 3.16e-17 Intelligence (multi-trait analysis); LUSC cis rs6430585 0.528 rs309119 chr2:136710372 T/C cg07169764 chr2:136633963 MCM6 1.02 15.35 0.64 1.35e-40 Corneal structure; LUSC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg18512352 chr11:47633146 NA -0.44 -9.33 -0.45 1.55e-18 Subjective well-being; LUSC cis rs877282 0.891 rs34383514 chr10:800181 T/C cg17470449 chr10:769945 NA 0.49 6.44 0.33 4.26e-10 Uric acid levels; LUSC trans rs35110281 0.720 rs162374 chr21:44927089 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.64 -11.16 -0.52 8.6e-25 Mean corpuscular volume; LUSC trans rs8072100 0.846 rs6503796 chr17:45765249 T/C cg03886242 chr7:26192032 NFE2L3 -0.41 -6.57 -0.34 1.99e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg02564969 chr6:151773285 C6orf211;RMND1 0.44 6.76 0.35 6.23e-11 Menarche (age at onset); LUSC cis rs9287719 0.837 rs4233882 chr2:10755564 A/G cg03983476 chr2:10830698 NOL10 -0.38 -5.77 -0.3 1.79e-8 Prostate cancer; LUSC trans rs747782 0.528 rs16905753 chr11:48285906 C/T cg03929089 chr4:120376271 NA 0.64 6.17 0.32 1.96e-9 Intraocular pressure; LUSC cis rs7084921 0.578 rs7474935 chr10:101875936 G/C cg02250046 chr10:101825185 CPN1 -0.35 -6.27 -0.32 1.09e-9 Bone mineral density; LUSC cis rs79911532 0.515 rs80171070 chr7:75636868 T/C cg03592824 chr7:75666768 STYXL1 0.72 7.12 0.36 6.54e-12 Mononucleosis; LUSC trans rs853679 0.546 rs200953 chr6:27837267 T/C cg06606381 chr12:133084897 FBRSL1 -0.75 -7.46 -0.38 7.39e-13 Depression; LUSC cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg08999081 chr20:33150536 PIGU 0.52 10.25 0.49 1.28e-21 Coronary artery disease; LUSC cis rs1371867 0.817 rs1660315 chr8:101332956 G/A cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs7605827 0.930 rs11687702 chr2:15682857 T/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.954 rs4309825 chr4:120314881 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.44 -6.34 -0.33 7.42e-10 Corneal astigmatism; LUSC cis rs34779708 0.966 rs2126984 chr10:35410291 A/G cg03585969 chr10:35415529 CREM 0.54 8.21 0.41 4.87e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg15445000 chr17:37608096 MED1 -0.41 -6.98 -0.36 1.59e-11 Glomerular filtration rate (creatinine); LUSC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg24324837 chr19:49891574 CCDC155 0.44 5.98 0.31 5.59e-9 Multiple sclerosis; LUSC cis rs10193935 0.901 rs222468 chr2:42642531 C/T cg27598129 chr2:42591480 NA -0.6 -8.22 -0.41 4.67e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11644478 chr21:40555479 PSMG1 0.63 10.2 0.49 1.94e-21 Cognitive function; LUSC cis rs907612 0.638 rs11041476 chr11:1875067 C/T cg26158194 chr11:1874320 LSP1 0.36 6.62 0.34 1.47e-10 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg13390004 chr1:15929781 NA 0.4 6.65 0.34 1.19e-10 Systolic blood pressure; LUSC cis rs6840360 0.571 rs72728182 chr4:152487027 T/C cg22705602 chr4:152727874 NA -0.33 -6.67 -0.34 1.08e-10 Intelligence (multi-trait analysis); LUSC cis rs796364 0.694 rs1653299 chr2:201075611 A/G cg17644776 chr2:200775616 C2orf69 0.39 6.16 0.32 2.1e-9 Schizophrenia; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.87 -0.35 3.17e-11 Monocyte percentage of white cells; LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg21226059 chr5:178986404 RUFY1 0.56 9.77 0.47 5.56e-20 Lung cancer; LUSC trans rs800082 0.690 rs800081 chr3:144339980 C/T cg24215973 chr2:240111563 HDAC4 0.62 9.87 0.48 2.54e-20 Smoking behavior; LUSC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg21724239 chr8:58056113 NA 0.63 7.4 0.38 1.08e-12 Developmental language disorder (linguistic errors); LUSC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg07777115 chr5:623756 CEP72 -0.46 -5.89 -0.31 9.3e-9 Obesity-related traits; LUSC cis rs10089 1.000 rs2898096 chr5:127433214 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.4 0.56 2.68e-29 Ileal carcinoids; LUSC cis rs300703 0.816 rs449725 chr2:202993 C/G cg21211680 chr2:198530 NA -0.67 -7.17 -0.37 4.82e-12 Blood protein levels; LUSC cis rs4700695 0.841 rs251294 chr5:65261848 A/G cg21114390 chr5:65439923 SFRS12 0.49 5.64 0.3 3.56e-8 Facial morphology (factor 19); LUSC cis rs1461503 0.932 rs10892934 chr11:122837950 C/T cg27398637 chr11:122830231 C11orf63 -0.42 -6.71 -0.34 8.41e-11 Menarche (age at onset); LUSC cis rs950169 0.580 rs11635597 chr15:85165699 C/T cg17173187 chr15:85201210 NMB 0.49 9.27 0.45 2.34e-18 Schizophrenia; LUSC trans rs62238980 0.614 rs117826138 chr22:32398149 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg06636001 chr8:8085503 FLJ10661 -0.59 -9.11 -0.45 8.04e-18 Systolic blood pressure; LUSC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg14416269 chr4:6271139 WFS1 0.5 10.62 0.5 6.83e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11077773 1.000 rs11077773 chr17:73060073 C/T cg27626185 chr17:73056755 KCTD2 0.85 9.48 0.46 5.07e-19 Information processing speed; LUSC cis rs9865818 0.702 rs2030519 chr3:188119901 G/A cg23651889 chr3:188115336 LPP -0.39 -6.06 -0.31 3.64e-9 Allergic sensitization; LUSC cis rs713477 0.692 rs56280202 chr14:55911201 C/T cg13175173 chr14:55914753 NA -0.3 -6.12 -0.32 2.66e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs3862030 0.694 rs1984795 chr10:104226830 C/T cg05855489 chr10:104503620 C10orf26 0.49 7.4 0.38 1.1e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7107174 1.000 rs7104222 chr11:78007169 G/A cg02023728 chr11:77925099 USP35 0.49 7.33 0.37 1.79e-12 Testicular germ cell tumor; LUSC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg03060546 chr3:49711283 APEH 0.72 12.18 0.55 1.79e-28 Resting heart rate; LUSC cis rs2806561 0.765 rs681395 chr1:23500314 G/A cg19743168 chr1:23544995 NA 0.43 8.21 0.41 4.9e-15 Height; LUSC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg05623727 chr3:50126028 RBM5 0.33 6.02 0.31 4.62e-9 Intelligence (multi-trait analysis); LUSC cis rs12950390 0.853 rs4793647 chr17:45854090 G/C cg03474202 chr17:45855739 NA -0.29 -6.62 -0.34 1.44e-10 IgG glycosylation; LUSC cis rs3617 0.573 rs4687682 chr3:52916939 T/C cg18404041 chr3:52824283 ITIH1 0.42 7.22 0.37 3.57e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08286799 chr16:89989483 TUBB3 0.44 6.37 0.33 6.44e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4604732 0.588 rs74154678 chr1:247626202 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs11098499 0.821 rs10032151 chr4:120391628 C/T cg24375607 chr4:120327624 NA 0.78 11.49 0.53 5.51e-26 Corneal astigmatism; LUSC cis rs6681460 0.546 rs4143025 chr1:67167548 A/G cg02459107 chr1:67143332 SGIP1 -0.33 -5.8 -0.3 1.5e-8 Presence of antiphospholipid antibodies; LUSC cis rs611744 0.608 rs612744 chr8:109245991 G/A cg18478394 chr8:109455254 TTC35 0.41 6.31 0.33 8.86e-10 Dupuytren's disease; LUSC cis rs9311676 0.656 rs66793022 chr3:58391565 C/T cg26110898 chr3:58419937 PDHB 0.4 6.44 0.33 4.09e-10 Systemic lupus erythematosus; LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 6.44 0.33 4.27e-10 Platelet count; LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg26314531 chr2:26401878 FAM59B 0.74 10.09 0.48 4.67e-21 Gut microbiome composition (summer); LUSC trans rs7746199 0.668 rs7749305 chr6:27446566 T/C cg01620082 chr3:125678407 NA -0.68 -6.72 -0.35 7.9e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs2639990 1.000 rs609303 chr18:72895242 C/T cg02750262 chr18:72916776 ZADH2 0.6 7.33 0.37 1.76e-12 Vascular endothelial growth factor levels; LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.3 0.41 2.67e-15 Prudent dietary pattern; LUSC cis rs35146811 0.555 rs2527896 chr7:99537653 A/G cg22906224 chr7:99728672 NA 0.43 5.8 0.3 1.56e-8 Coronary artery disease; LUSC cis rs1775715 0.835 rs1419169 chr10:32257204 C/G cg04359828 chr10:32216031 ARHGAP12 0.38 6.25 0.32 1.27e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg06238570 chr21:40685208 BRWD1 -0.64 -10.7 -0.51 3.63e-23 Cognitive function; LUSC cis rs611744 0.647 rs615126 chr8:109247619 C/T cg18478394 chr8:109455254 TTC35 0.41 6.28 0.32 1.05e-9 Dupuytren's disease; LUSC cis rs9341808 0.718 rs2322630 chr6:80841033 A/G cg08355045 chr6:80787529 NA 0.58 10.05 0.48 6.07e-21 Sitting height ratio; LUSC cis rs59072704 0.843 rs12031783 chr1:244498748 A/G cg16908123 chr1:244486252 NA 0.33 6.48 0.33 3.29e-10 Monocyte count; LUSC cis rs4930103 0.619 rs10769945 chr11:1985127 C/T cg23202291 chr11:1979235 NA 0.49 7.83 0.39 6.49e-14 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg13319975 chr6:146136371 FBXO30 0.46 6.93 0.35 2.19e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs59104589 0.569 rs4254498 chr2:242363611 G/C cg14842376 chr2:242211374 HDLBP 0.54 6.25 0.32 1.22e-9 Fibrinogen levels; LUSC cis rs2273669 0.667 rs12195372 chr6:109284223 A/G cg05315195 chr6:109294784 ARMC2 -0.58 -6.47 -0.33 3.44e-10 Prostate cancer; LUSC cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg25427524 chr10:38739819 LOC399744 -0.74 -13.92 -0.61 4.61e-35 Extrinsic epigenetic age acceleration; LUSC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.44 7.04 0.36 1.11e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1971762 0.563 rs11170645 chr12:54079080 G/T cg23533419 chr12:54090519 NA -0.37 -6.05 -0.31 3.94e-9 Height; LUSC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg00933542 chr6:150070202 PCMT1 0.31 6.48 0.33 3.27e-10 Lung cancer; LUSC cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg03264133 chr6:25882463 NA 0.39 6.73 0.35 7.47e-11 Blood metabolite levels; LUSC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.31 0.45 1.75e-18 Total body bone mineral density; LUSC cis rs13082711 0.689 rs34946790 chr3:27345170 G/A cg02860705 chr3:27208620 NA 0.78 12.55 0.57 7.54e-30 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs1670533 1.000 rs10084890 chr4:1053934 C/G cg02018176 chr4:1364513 KIAA1530 -0.4 -5.92 -0.31 7.94e-9 Recombination rate (females); LUSC cis rs28595532 0.623 rs10016452 chr4:119277490 A/G cg21605333 chr4:119757512 SEC24D 0.94 7.7 0.39 1.56e-13 Cannabis dependence symptom count; LUSC cis rs72634258 0.554 rs4908705 chr1:7926401 C/T cg26816564 chr1:7831052 VAMP3 0.69 9.59 0.46 2.08e-19 Inflammatory bowel disease; LUSC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs925255 0.591 rs7559046 chr2:28644670 G/C cg01273330 chr2:28605224 NA -0.4 -6.44 -0.33 4.23e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.99 0.31 5.57e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1729951 0.575 rs361239 chr3:136701295 G/T cg21827317 chr3:136751795 NA 0.38 6.95 0.36 1.87e-11 Neuroticism; LUSC cis rs7614311 0.731 rs73130544 chr3:63868596 G/A cg22134162 chr3:63841271 THOC7 -0.49 -6.07 -0.32 3.43e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs6743030 0.521 rs1254901 chr2:85811229 G/A cg17127132 chr2:85788382 GGCX -0.43 -5.88 -0.31 9.75e-9 Coronary artery disease; LUSC cis rs2346177 0.844 rs34712412 chr2:46652428 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.63 -0.39 2.5e-13 HDL cholesterol; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg20307385 chr11:47447363 PSMC3 -0.45 -5.95 -0.31 6.71e-9 Subjective well-being; LUSC trans rs637571 0.522 rs3016868 chr11:65764383 C/T cg17712092 chr4:129076599 LARP1B 0.72 10.84 0.51 1.12e-23 Eosinophil percentage of white cells; LUSC cis rs10872587 0.657 rs11155459 chr6:146578751 A/G cg23711669 chr6:146136114 FBXO30 -0.56 -7.55 -0.38 4.28e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs3858526 0.834 rs7116627 chr11:5985550 T/C cg05234568 chr11:5960015 NA -0.63 -8.97 -0.44 2.1e-17 DNA methylation (variation); LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg18538332 chr22:24372958 LOC391322 -0.47 -8.47 -0.42 8.05e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg18512352 chr11:47633146 NA 0.47 9.53 0.46 3.24e-19 Subjective well-being; LUSC cis rs1348850 0.750 rs13031008 chr2:178477114 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 5.84 0.3 1.25e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7719624 0.756 rs6880837 chr5:135396669 A/G cg12897067 chr5:135418308 NA 0.4 5.8 0.3 1.51e-8 Response to cytidine analogues (gemcitabine); LUSC cis rs11098499 0.820 rs12503082 chr4:120284317 A/G cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.81e-10 Bipolar disorder; LUSC cis rs9902453 1.000 rs7207021 chr17:28400516 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.98 -0.44 2.08e-17 Coffee consumption (cups per day); LUSC cis rs62400317 0.762 rs10456120 chr6:44900107 C/T cg20913747 chr6:44695427 NA -0.48 -7.47 -0.38 7.22e-13 Total body bone mineral density; LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg18404041 chr3:52824283 ITIH1 -0.62 -12.25 -0.56 9.44e-29 Bipolar disorder; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25365783 chr7:108166722 PNPLA8 0.37 6.34 0.33 7.59e-10 Triglycerides; LUSC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg11344533 chr11:111475393 SIK2 -0.5 -6.95 -0.36 1.88e-11 Primary sclerosing cholangitis; LUSC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg21951975 chr1:209979733 IRF6 0.56 8.5 0.42 6.6e-16 Cleft lip with or without cleft palate; LUSC cis rs59104589 0.617 rs3771566 chr2:242358299 G/T cg14842376 chr2:242211374 HDLBP 0.55 6.33 0.33 7.87e-10 Fibrinogen levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04849129 chr2:191513396 NAB1 -0.48 -6.25 -0.32 1.27e-9 Hepatitis; LUSC cis rs1595825 0.735 rs1866665 chr2:198925980 A/G cg00982548 chr2:198649783 BOLL -0.54 -6.56 -0.34 2.11e-10 Ulcerative colitis; LUSC cis rs11122272 0.764 rs4486439 chr1:231477470 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.62 -9.43 -0.46 7.39e-19 Hemoglobin concentration; LUSC cis rs10191773 0.535 rs11123133 chr2:112965023 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.76 8.37 0.42 1.62e-15 Yeast infection; LUSC trans rs11098499 0.863 rs3775848 chr4:120447724 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.55 0.34 2.17e-10 Corneal astigmatism; LUSC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg06238570 chr21:40685208 BRWD1 -0.59 -9.14 -0.45 6e-18 Menarche (age at onset); LUSC cis rs56399783 0.708 rs56208415 chr7:2813806 G/A cg19731401 chr7:2775893 GNA12 0.6 8.06 0.4 1.37e-14 Childhood ear infection; LUSC cis rs7216064 0.906 rs7223643 chr17:65830282 A/G cg12091567 chr17:66097778 LOC651250 -0.71 -8.53 -0.42 5.28e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg10518543 chr12:38710700 ALG10B -0.41 -5.67 -0.3 3.1e-8 Morning vs. evening chronotype; LUSC cis rs738322 0.935 rs4384 chr22:38572440 G/C cg17652424 chr22:38574118 PLA2G6 -0.27 -5.81 -0.3 1.48e-8 Cutaneous nevi; LUSC cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg07606381 chr6:8435919 SLC35B3 0.72 12.43 0.56 1.96e-29 Motion sickness; LUSC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg15790184 chr11:494944 RNH1 0.5 7.46 0.38 7.36e-13 Systemic lupus erythematosus; LUSC cis rs55665837 0.961 rs60622588 chr11:14456998 T/C cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 7.25e-13 Vitamin D levels; LUSC cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg16322792 chr1:120165303 ZNF697 0.74 15.5 0.65 3.38e-41 Systemic lupus erythematosus; LUSC cis rs983392 0.709 rs2162254 chr11:60039917 T/A cg02771260 chr11:59836817 MS4A3 0.37 6.11 0.32 2.75e-9 Alzheimer's disease (late onset); LUSC cis rs6598955 0.671 rs57386998 chr1:26569821 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs11098499 0.955 rs35916640 chr4:120155852 T/C cg09307838 chr4:120376055 NA 0.69 10.01 0.48 8.32e-21 Corneal astigmatism; LUSC cis rs7119 0.651 rs12915057 chr15:77847745 C/A cg27398640 chr15:77910606 LINGO1 -0.33 -7.04 -0.36 1.12e-11 Type 2 diabetes; LUSC cis rs983392 0.805 rs11230183 chr11:59965725 C/T cg02771260 chr11:59836817 MS4A3 -0.36 -5.77 -0.3 1.79e-8 Alzheimer's disease (late onset); LUSC cis rs7647973 0.710 rs11130207 chr3:49611666 T/G cg03060546 chr3:49711283 APEH 0.64 6.96 0.36 1.76e-11 Menarche (age at onset); LUSC cis rs11098499 0.542 rs7677836 chr4:120310638 T/A cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg08470875 chr2:26401718 FAM59B -0.68 -8.95 -0.44 2.53e-17 Gut microbiome composition (summer); LUSC cis rs10392 0.543 rs6028197 chr20:37534193 C/T cg27552599 chr20:37590471 DHX35 0.44 6.98 0.36 1.6e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs4494114 0.967 rs11211566 chr1:39354700 G/C cg25970120 chr1:39325951 RRAGC -0.4 -6.19 -0.32 1.8e-9 Blood protein levels; LUSC cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg16339924 chr4:17578868 LAP3 0.51 7.58 0.38 3.42e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg09044154 chr16:88155775 NA -0.55 -7.27 -0.37 2.52e-12 Menopause (age at onset); LUSC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.83 0.3 1.3e-8 Intelligence (multi-trait analysis); LUSC cis rs2573652 1.000 rs2581343 chr15:100514418 C/G cg09918751 chr15:100517450 ADAMTS17 -0.46 -8.59 -0.43 3.38e-16 Height; LUSC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg06027949 chr8:82754900 SNX16 -0.43 -5.81 -0.3 1.48e-8 Diastolic blood pressure; LUSC trans rs890100 0.673 rs4141567 chr2:56658057 A/G cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.75e-9 Gut microbiome composition (summer); LUSC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg03433033 chr1:76189801 ACADM 0.74 11.2 0.52 5.99e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4363385 0.643 rs12734348 chr1:152924650 A/G cg07796016 chr1:152779584 LCE1C -0.49 -7.27 -0.37 2.63e-12 Inflammatory skin disease; LUSC cis rs6062509 0.811 rs6062498 chr20:62339059 C/G cg21849932 chr20:62369462 LIME1 -0.42 -6.1 -0.32 2.94e-9 Prostate cancer; LUSC cis rs7011049 1.000 rs79169015 chr8:53843908 C/T cg26025543 chr8:53854495 NA 0.53 6.35 0.33 7.13e-10 Systolic blood pressure; LUSC trans rs7824557 0.527 rs10109537 chr8:11239640 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.85 -0.35 3.67e-11 Retinal vascular caliber; LUSC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg03538708 chr1:25844672 NA -0.37 -6.11 -0.32 2.71e-9 Erythrocyte sedimentation rate; LUSC cis rs4555082 0.915 rs28594491 chr14:105758018 G/A cg10792982 chr14:105748885 BRF1 0.47 8.39 0.42 1.36e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg07362569 chr17:61921086 SMARCD2 0.37 7.27 0.37 2.5e-12 Prudent dietary pattern; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg22166914 chr1:53195759 ZYG11B 0.49 7.84 0.39 6.05e-14 Monocyte count; LUSC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg14440974 chr22:39074834 NA -0.35 -5.86 -0.31 1.11e-8 Menopause (age at onset); LUSC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg04362960 chr10:104952993 NT5C2 0.58 9.07 0.44 1.03e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg12288994 chr5:1860383 NA 0.3 6.57 0.34 1.95e-10 Cardiovascular disease risk factors; LUSC cis rs8028313 0.731 rs4331293 chr15:67987801 A/G cg27219399 chr15:67835830 MAP2K5 0.38 6.07 0.32 3.48e-9 Obesity; LUSC cis rs6570726 0.559 rs11754523 chr6:145727951 A/G cg23711669 chr6:146136114 FBXO30 -0.49 -6.99 -0.36 1.49e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg06740227 chr12:86229804 RASSF9 0.38 6.06 0.31 3.64e-9 Major depressive disorder; LUSC cis rs4803468 1.000 rs3810174 chr19:41904165 C/T cg09537434 chr19:41945824 ATP5SL -0.89 -15.81 -0.65 2.07e-42 Height; LUSC cis rs1957429 0.520 rs72625645 chr14:65343431 G/C cg23373153 chr14:65346875 NA -0.88 -8.03 -0.4 1.74e-14 Pediatric areal bone mineral density (radius); LUSC cis rs12681287 0.605 rs2976181 chr8:87344470 C/T cg27223183 chr8:87520930 FAM82B -0.43 -5.92 -0.31 8.11e-9 Caudate activity during reward; LUSC cis rs6121246 0.609 rs6060948 chr20:30376393 C/G cg13852791 chr20:30311386 BCL2L1 0.93 14.18 0.61 4.78e-36 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg08677398 chr8:58056175 NA 0.54 6.37 0.33 6.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg00579200 chr11:133705235 NA -0.4 -6.05 -0.31 3.86e-9 Childhood ear infection; LUSC cis rs11098499 0.530 rs114866537 chr4:120258608 A/T cg24375607 chr4:120327624 NA 0.72 11.69 0.54 1.05e-26 Corneal astigmatism; LUSC cis rs72827839 0.516 rs111630961 chr17:45938097 T/G cg23391107 chr17:45924227 SP6 0.42 7.42 0.38 9.86e-13 Ease of getting up in the morning; LUSC cis rs9527 0.567 rs6584539 chr10:104879402 G/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg05025164 chr4:1340916 KIAA1530 0.42 6.34 0.33 7.29e-10 Obesity-related traits; LUSC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg17366294 chr4:99064904 C4orf37 0.61 10.91 0.51 6.76e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg15664640 chr17:80829946 TBCD 0.47 8.5 0.42 6.41e-16 Breast cancer; LUSC cis rs7568458 0.811 rs1446668 chr2:85764960 G/T cg02493740 chr2:85810744 VAMP5 -0.37 -6.59 -0.34 1.76e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1801251 1.000 rs2674839 chr2:233669040 G/C cg08000102 chr2:233561755 GIGYF2 0.71 11.84 0.54 3.11e-27 Coronary artery disease; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg07092213 chr7:1199455 ZFAND2A -0.54 -8.75 -0.43 1.1e-16 Longevity;Endometriosis; LUSC cis rs9815354 0.951 rs9831404 chr3:41871825 T/G cg03022575 chr3:42003672 ULK4 0.58 6.56 0.34 2e-10 Pulse pressure;Diastolic blood pressure; LUSC trans rs2832077 0.943 rs2832094 chr21:30165910 G/A cg14791747 chr16:20752902 THUMPD1 0.71 9.62 0.47 1.72e-19 Cognitive test performance; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.01 0.77 5.62e-67 Prudent dietary pattern; LUSC cis rs8028313 0.630 rs3784700 chr15:68017752 A/G cg24579218 chr15:68104479 NA -0.38 -6.43 -0.33 4.3e-10 Obesity; LUSC cis rs7122539 0.839 rs6591223 chr11:66609289 C/T cg24851651 chr11:66362959 CCS 0.47 7.53 0.38 4.93e-13 HIV-1 susceptibility; LUSC cis rs4319547 0.698 rs10744217 chr12:122942070 A/G cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.27 -0.41 3.32e-15 Body mass index; LUSC cis rs72960926 0.744 rs72950543 chr6:74907232 G/A cg03266952 chr6:74778945 NA -0.78 -6.27 -0.32 1.12e-9 Metabolite levels (MHPG); LUSC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg15704280 chr7:45808275 SEPT13 -1.08 -19.9 -0.74 1.14e-58 Coronary artery disease; LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18404041 chr3:52824283 ITIH1 -0.57 -11.1 -0.52 1.41e-24 Bipolar disorder; LUSC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg21724239 chr8:58056113 NA 0.74 7.98 0.4 2.4e-14 Developmental language disorder (linguistic errors); LUSC cis rs2635047 0.967 rs2576056 chr18:44675462 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 7.01 0.36 1.32e-11 Educational attainment; LUSC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg25036284 chr2:26402008 FAM59B -0.7 -9.88 -0.48 2.22e-20 Gut microbiome composition (summer); LUSC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg14552801 chr7:65878734 NA 0.37 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg18876405 chr7:65276391 NA 0.75 13.54 0.6 1.3e-33 Aortic root size; LUSC cis rs6901250 0.851 rs9374624 chr6:117145837 A/C cg12892004 chr6:117198278 RFX6 0.44 8.35 0.42 1.83e-15 C-reactive protein levels; LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs500891 0.533 rs9969045 chr6:84185399 T/G cg08257003 chr6:84140564 ME1 0.33 7.97 0.4 2.58e-14 Platelet-derived growth factor BB levels; LUSC cis rs8113142 0.550 rs66459748 chr19:29131294 T/G cg04546413 chr19:29218101 NA 0.4 5.79 0.3 1.62e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs7903847 0.620 rs10882904 chr10:99115683 A/G cg20016023 chr10:99160130 RRP12 -0.33 -7.96 -0.4 2.77e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg06637938 chr14:75390232 RPS6KL1 0.52 8.35 0.42 1.87e-15 Height; LUSC cis rs11971779 0.527 rs4379397 chr7:139043385 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs908922 0.676 rs539393 chr1:152518896 C/T cg20991723 chr1:152506922 NA 0.5 9.28 0.45 2.18e-18 Hair morphology; LUSC trans rs2236293 0.724 rs11791889 chr9:35860942 G/A cg11239633 chr3:37903682 CTDSPL -0.33 -5.99 -0.31 5.38e-9 Blood protein levels; LUSC cis rs12421382 0.811 rs11602639 chr11:109472829 C/T cg11473876 chr11:109292803 C11orf87 0.38 6.04 0.31 4e-9 Schizophrenia; LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg00431813 chr7:1051703 C7orf50 0.47 7.95 0.4 2.94e-14 Longevity;Endometriosis; LUSC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg13877915 chr19:58951672 ZNF132 0.5 7.97 0.4 2.57e-14 Uric acid clearance; LUSC cis rs9467773 0.620 rs2451744 chr6:26633463 G/T cg09904177 chr6:26538194 HMGN4 0.65 11.7 0.54 9.83e-27 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16275883 chr3:69129409 UBA3 0.48 6.46 0.33 3.66e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg03929089 chr4:120376271 NA 0.95 15.15 0.64 7.72e-40 Coronary artery disease; LUSC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg18876405 chr7:65276391 NA -0.58 -9.5 -0.46 4.35e-19 Aortic root size; LUSC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg21951975 chr1:209979733 IRF6 0.55 6.99 0.36 1.53e-11 Cleft lip with or without cleft palate; LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.76 0.47 5.92e-20 Bipolar disorder; LUSC cis rs7267979 1.000 rs6115153 chr20:25325567 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.56 -0.75 2.74e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg13560548 chr3:10150139 C3orf24 0.48 6.75 0.35 6.62e-11 Alzheimer's disease; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg22185043 chr18:12947723 SEH1L 0.62 6.03 0.31 4.33e-9 Myocardial infarction; LUSC cis rs5167 0.781 rs909134 chr19:45493061 T/C cg13119609 chr19:45449297 APOC2 0.33 5.74 0.3 2.09e-8 Blood protein levels; LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg07167872 chr1:205819463 PM20D1 0.47 6.93 0.35 2.19e-11 Menarche (age at onset); LUSC cis rs983392 0.709 rs11603507 chr11:59982470 T/A cg24026212 chr11:59952134 MS4A6A -0.35 -6.09 -0.32 3.18e-9 Alzheimer's disease (late onset); LUSC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg00814883 chr7:100076585 TSC22D4 -0.74 -10.01 -0.48 8.51e-21 Platelet count; LUSC cis rs9653442 1.000 rs6712515 chr2:100806514 T/C cg07810366 chr2:100720526 AFF3 -0.44 -7.72 -0.39 1.33e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg21984481 chr17:79567631 NPLOC4 -0.69 -14.08 -0.61 1.09e-35 Eye color traits; LUSC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg00310523 chr12:86230176 RASSF9 -0.42 -8.0 -0.4 2e-14 Major depressive disorder; LUSC cis rs9393777 0.920 rs13191227 chr6:27390115 G/C cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.04e-9 Intelligence (multi-trait analysis); LUSC trans rs62238980 0.522 rs2413065 chr22:32458608 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs9527 0.615 rs17725614 chr10:104685493 G/C cg08330031 chr10:104623503 C10orf32 0.32 5.69 0.3 2.76e-8 Arsenic metabolism; LUSC cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.85 0.3 1.17e-8 Personality dimensions; LUSC trans rs7395662 0.548 rs4882000 chr11:48546496 A/G cg03929089 chr4:120376271 NA -0.44 -6.11 -0.32 2.7e-9 HDL cholesterol; LUSC trans rs28588043 0.593 rs9427209 chr1:170942402 A/G cg07135042 chr19:56905152 ZNF582 -0.61 -6.09 -0.32 3.02e-9 Number of children (6+ vs. 0 or 1); LUSC cis rs6967385 0.560 rs4301352 chr7:12356481 T/G cg10578991 chr7:12443926 VWDE 0.4 5.94 0.31 7.15e-9 Response to taxane treatment (placlitaxel); LUSC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg03929089 chr4:120376271 NA 0.93 15.0 0.63 2.95e-39 Coronary artery disease; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg26354017 chr1:205819088 PM20D1 0.86 15.58 0.65 1.6e-41 Menarche (age at onset); LUSC cis rs4792901 0.694 rs9907819 chr17:41602865 T/C cg22562494 chr17:41607896 ETV4 -0.33 -6.05 -0.31 3.8e-9 Dupuytren's disease; LUSC cis rs208520 0.690 rs12189780 chr6:66759619 G/A cg07460842 chr6:66804631 NA 1.1 17.28 0.69 3.11e-48 Exhaled nitric oxide output; LUSC cis rs17253792 0.822 rs77599953 chr14:56058905 C/T cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs868036 0.718 rs28675295 chr15:68116400 C/A cg08079166 chr15:68083412 MAP2K5 0.41 7.34 0.37 1.68e-12 Restless legs syndrome; LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs250677 0.522 rs2895837 chr5:148357535 C/T cg18129178 chr5:148520854 ABLIM3 0.53 7.41 0.38 1.02e-12 Breast cancer; LUSC cis rs17255340 0.539 rs1013318 chr6:83979447 A/G cg08257003 chr6:84140564 ME1 -0.3 -7.12 -0.36 6.65e-12 Platelet-derived growth factor BB levels; LUSC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg21724239 chr8:58056113 NA 0.55 6.65 0.34 1.23e-10 Developmental language disorder (linguistic errors); LUSC trans rs11782517 0.883 rs12544801 chr8:10107382 C/G cg06636001 chr8:8085503 FLJ10661 0.48 6.24 0.32 1.3e-9 Nose size; LUSC cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.38 0.64 9.57e-41 Bladder cancer; LUSC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC trans rs11992162 0.597 rs6996342 chr8:11784541 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.06 -0.31 3.66e-9 Monocyte count; LUSC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg12310025 chr6:25882481 NA -0.47 -8.08 -0.4 1.16e-14 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17407411 chr12:1800083 ADIPOR2 0.69 5.99 0.31 5.5e-9 Cognitive performance; LUSC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg00152838 chr16:24741724 TNRC6A 0.45 5.65 0.3 3.45e-8 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg19812747 chr11:111475976 SIK2 -0.55 -7.98 -0.4 2.29e-14 Primary sclerosing cholangitis; LUSC cis rs72960926 0.744 rs7776273 chr6:74967693 T/C cg03266952 chr6:74778945 NA -0.78 -6.91 -0.35 2.47e-11 Metabolite levels (MHPG); LUSC cis rs11098499 0.954 rs6834796 chr4:120414693 A/C cg09307838 chr4:120376055 NA 0.79 11.74 0.54 7.16e-27 Corneal astigmatism; LUSC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg17333051 chr19:2783644 SGTA -0.49 -7.38 -0.37 1.24e-12 Total cholesterol levels; LUSC cis rs4803468 0.967 rs3213860 chr19:41920211 T/C cg09537434 chr19:41945824 ATP5SL -0.92 -15.96 -0.66 4.93e-43 Height; LUSC cis rs2074585 0.839 rs11638780 chr15:91041896 G/T cg22089800 chr15:90895588 ZNF774 -0.64 -9.65 -0.47 1.3e-19 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs381815 0.924 rs7926335 chr11:16917869 C/T cg05701403 chr11:16947551 PLEKHA7 0.39 5.92 0.31 7.97e-9 Diastolic blood pressure;Systolic blood pressure;Blood pressure; LUSC cis rs4478037 0.822 rs9827863 chr3:33118951 C/T cg19404215 chr3:33155277 CRTAP -0.96 -9.67 -0.47 1.18e-19 Major depressive disorder; LUSC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -10.29 -0.49 9.32e-22 Menarche (age at onset); LUSC cis rs11031096 0.617 rs12288918 chr11:4191466 G/T cg18678763 chr11:4115507 RRM1 -0.41 -5.76 -0.3 1.96e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg15556689 chr8:8085844 FLJ10661 -0.63 -9.54 -0.46 3.09e-19 Neuroticism; LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg14092988 chr3:52407081 DNAH1 -0.32 -6.27 -0.32 1.1e-9 Bipolar disorder; LUSC cis rs2742417 0.603 rs2742458 chr3:45767602 C/T cg10512202 chr3:45649293 LIMD1 0.36 5.93 0.31 7.48e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs509477 0.718 rs273344 chr18:32603927 C/T cg23791764 chr18:32556832 MAPRE2 0.4 5.79 0.3 1.65e-8 Cerebrospinal fluid AB1-42 levels; LUSC cis rs1595825 0.891 rs76450397 chr2:198786112 T/C cg00982548 chr2:198649783 BOLL -0.56 -7.04 -0.36 1.12e-11 Ulcerative colitis; LUSC cis rs10911232 0.507 rs12037623 chr1:183000148 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs2303759 0.670 rs45549132 chr19:49794028 G/T cg22590775 chr19:49891494 CCDC155 0.53 6.99 0.36 1.52e-11 Multiple sclerosis; LUSC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg00033643 chr7:134001901 SLC35B4 0.47 7.19 0.37 4.22e-12 Mean platelet volume; LUSC cis rs11997175 0.624 rs4733179 chr8:33692223 T/G ch.8.33884649F chr8:33765107 NA 0.44 6.57 0.34 1.93e-10 Body mass index; LUSC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg02931644 chr1:25747376 RHCE 0.36 6.45 0.33 3.85e-10 Erythrocyte sedimentation rate; LUSC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02443732 chr16:88804373 FAM38A 0.4 6.41 0.33 5.04e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9329221 0.905 rs4433149 chr8:10249268 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.26 -0.41 3.42e-15 Neuroticism; LUSC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs7408868 0.563 rs10404382 chr19:15301389 C/A cg14696996 chr19:15285081 NOTCH3 0.77 7.83 0.39 6.51e-14 Pulse pressure; LUSC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg03477792 chr4:77819574 ANKRD56 0.62 8.86 0.44 4.88e-17 Emphysema distribution in smoking; LUSC cis rs9487051 0.799 rs351725 chr6:109547939 G/A cg01475377 chr6:109611718 NA -0.35 -5.83 -0.3 1.28e-8 Reticulocyte fraction of red cells; LUSC cis rs425277 1.000 rs1401138 chr1:2063149 C/T cg24578937 chr1:2090814 PRKCZ 0.58 13.16 0.58 3.73e-32 Height; LUSC cis rs6998277 0.830 rs965661 chr8:103597586 C/T cg10187029 chr8:103597600 NA 0.77 11.83 0.54 3.41e-27 Migraine; LUSC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.03 0.66 2.64e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2730245 0.636 rs2657382 chr7:158650941 G/A cg14689365 chr7:158441557 NCAPG2 0.51 7.33 0.37 1.72e-12 Height; LUSC cis rs4343996 0.935 rs10276190 chr7:3348663 C/T cg21248987 chr7:3385318 SDK1 0.4 6.74 0.35 6.99e-11 Motion sickness; LUSC trans rs6502050 0.871 rs6502056 chr17:80070912 C/G cg07393940 chr7:158741817 NA -0.37 -6.59 -0.34 1.73e-10 Life satisfaction; LUSC cis rs10207628 0.698 rs10182292 chr2:127869462 G/A cg06223080 chr2:127868745 NA 0.38 6.56 0.34 2.06e-10 Psychosis and Alzheimer's disease; LUSC cis rs9650657 0.740 rs34653170 chr8:10676542 G/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.1 -0.32 2.85e-9 Neuroticism; LUSC cis rs17604090 0.823 rs28415620 chr7:29701104 T/C cg19413766 chr7:29689036 LOC646762 -0.64 -7.7 -0.39 1.5700000000000001e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs13385 0.769 rs13175751 chr5:139601097 C/G cg26211634 chr5:139558579 C5orf32 0.45 6.81 0.35 4.63e-11 Atrial fibrillation; LUSC trans rs75804782 0.641 rs3769125 chr2:239349562 A/G cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.11e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs10193935 0.901 rs222471 chr2:42638057 C/T cg27598129 chr2:42591480 NA 0.59 8.17 0.41 6.48e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg10523679 chr1:76189770 ACADM -0.53 -7.75 -0.39 1.11e-13 Daytime sleep phenotypes; LUSC cis rs3018712 0.532 rs7116363 chr11:68412798 G/A cg20283391 chr11:68216788 NA 0.56 5.71 0.3 2.48e-8 Total body bone mineral density; LUSC cis rs10911232 0.507 rs4072709 chr1:183028855 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 11.15 0.52 9.13e-25 Hypertriglyceridemia; LUSC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg26677194 chr12:130822605 PIWIL1 0.59 8.77 0.43 9.52e-17 Menopause (age at onset); LUSC cis rs10464366 0.746 rs12670510 chr7:39142146 A/G cg20302533 chr7:39170763 POU6F2 0.51 7.94 0.4 3.08e-14 IgG glycosylation; LUSC trans rs7824557 0.527 rs11785394 chr8:11238029 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.22 -0.41 4.5e-15 Retinal vascular caliber; LUSC cis rs9807989 0.839 rs4988956 chr2:102968007 G/A cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC cis rs2540226 0.844 rs12712656 chr2:39993952 C/G cg23576258 chr2:39999331 THUMPD2 0.34 5.84 0.3 1.22e-8 Personality dimensions; LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg18301423 chr5:131593218 PDLIM4 0.42 6.67 0.34 1.07e-10 Blood metabolite levels; LUSC cis rs897984 0.806 rs12924903 chr16:30928970 C/T cg02466173 chr16:30829666 NA -0.54 -10.66 -0.5 4.9e-23 Dementia with Lewy bodies; LUSC cis rs6496667 0.557 rs2526002 chr15:90965655 C/T cg10434728 chr15:90938212 IQGAP1 0.31 6.07 0.32 3.53e-9 Rheumatoid arthritis; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg08888203 chr3:10149979 C3orf24 -0.65 -8.66 -0.43 2.02e-16 Alzheimer's disease; LUSC cis rs17604090 0.529 rs10239226 chr7:29716312 C/G cg19413766 chr7:29689036 LOC646762 -0.55 -7.46 -0.38 7.46e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg18681998 chr4:17616180 MED28 0.81 14.1 0.61 9.26e-36 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.64 11.22 0.52 5.14e-25 Bone mineral density (spine);Bone mineral density; LUSC cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg03060546 chr3:49711283 APEH -0.62 -8.9 -0.44 3.53e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg21535247 chr6:8435926 SLC35B3 0.59 9.03 0.44 1.37e-17 Motion sickness; LUSC trans rs561341 1.000 rs576985 chr17:30323323 C/T cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg00750074 chr16:89608354 SPG7 -0.57 -10.21 -0.49 1.71e-21 Multiple myeloma (IgH translocation); LUSC cis rs611744 0.604 rs6469170 chr8:109305277 T/C cg18478394 chr8:109455254 TTC35 0.44 6.93 0.35 2.21e-11 Dupuytren's disease; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg03579872 chr1:53393473 SCP2 -0.39 -5.79 -0.3 1.63e-8 Monocyte count; LUSC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg21984481 chr17:79567631 NPLOC4 -0.58 -11.03 -0.52 2.43e-24 Eye color traits; LUSC cis rs1729951 0.546 rs835632 chr3:136676525 A/T cg12473912 chr3:136751656 NA 0.37 6.45 0.33 3.83e-10 Neuroticism; LUSC cis rs7215564 0.822 rs10871488 chr17:78739079 T/C cg23238734 chr17:78661607 RPTOR -0.45 -5.71 -0.3 2.48e-8 Myopia (pathological); LUSC cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg03676636 chr4:99064102 C4orf37 0.27 5.84 0.3 1.24e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs2014572 0.967 rs10427146 chr19:57755998 T/C cg24459738 chr19:57751996 ZNF805 -0.52 -7.69 -0.39 1.66e-13 Hyperactive-impulsive symptoms; LUSC cis rs2219968 1.000 rs11777219 chr8:78959566 A/T cg00738934 chr8:78996279 NA 0.34 6.19 0.32 1.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg10755058 chr3:40428713 ENTPD3 0.35 5.9 0.31 9.01e-9 Renal cell carcinoma; LUSC cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.73 0.43 1.24e-16 Schizophrenia; LUSC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg23283495 chr1:209979779 IRF6 0.71 9.01 0.44 1.67e-17 Cleft lip with or without cleft palate; LUSC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.71 -9.19 -0.45 4.14e-18 Gut microbiome composition (summer); LUSC cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg11584989 chr19:19387371 SF4 0.59 6.71 0.34 8.21e-11 Bipolar disorder; LUSC trans rs1814175 0.645 rs28839231 chr11:50044292 G/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs4474465 1.000 rs6592780 chr11:78199888 C/G cg27205649 chr11:78285834 NARS2 -0.51 -5.91 -0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs68170813 0.559 rs7803290 chr7:106907353 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs951366 0.531 rs12047038 chr1:205718468 A/G cg11965913 chr1:205819406 PM20D1 -0.48 -6.71 -0.34 8.28e-11 Menarche (age at onset); LUSC cis rs7824557 0.564 rs2736300 chr8:11235579 T/G cg21775007 chr8:11205619 TDH -0.65 -10.3 -0.49 9.02e-22 Retinal vascular caliber; LUSC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC trans rs9388451 0.903 rs9388446 chr6:126064920 T/A cg05039488 chr6:79577232 IRAK1BP1 -0.58 -9.34 -0.46 1.38e-18 Brugada syndrome; LUSC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg22590775 chr19:49891494 CCDC155 0.62 8.77 0.43 9.56e-17 Multiple sclerosis; LUSC cis rs7520050 0.778 rs3013597 chr1:46128356 C/A cg06784218 chr1:46089804 CCDC17 0.29 5.83 0.3 1.31e-8 Red blood cell count;Reticulocyte count; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg20854551 chr18:61603789 NA 0.39 6.26 0.32 1.19e-9 Mosquito bite size; LUSC trans rs11098499 0.863 rs59732491 chr4:120489588 G/C cg25214090 chr10:38739885 LOC399744 0.55 8.13 0.41 8.28e-15 Corneal astigmatism; LUSC cis rs12594515 0.967 rs67854274 chr15:45990518 A/G cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.900 rs13144986 chr4:17675019 C/A cg16339924 chr4:17578868 LAP3 -0.61 -8.97 -0.44 2.13e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg23711669 chr6:146136114 FBXO30 -0.83 -14.81 -0.63 1.67e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs2760061 0.626 rs596675 chr1:228117892 G/A cg02753203 chr1:228287806 NA -0.66 -11.34 -0.53 1.95e-25 Diastolic blood pressure; LUSC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg18225595 chr11:63971243 STIP1 0.62 10.41 0.5 3.59e-22 Platelet count; LUSC trans rs3733585 0.699 rs1122142 chr4:9947548 G/C cg26043149 chr18:55253948 FECH -0.45 -6.85 -0.35 3.67e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs977987 0.806 rs12599361 chr16:75434973 A/T cg03315344 chr16:75512273 CHST6 0.48 8.95 0.44 2.56e-17 Dupuytren's disease; LUSC cis rs909685 1.000 rs909685 chr22:39747671 T/A cg17798944 chr22:39715225 SNORD43;RPL3 0.5 7.05 0.36 1.02e-11 Rheumatoid arthritis; LUSC cis rs6690583 0.562 rs11588919 chr1:85442813 A/T cg22153463 chr1:85462885 MCOLN2 0.63 6.01 0.31 4.85e-9 Serum sulfate level; LUSC trans rs10435719 0.902 rs7459545 chr8:11804389 G/T cg15556689 chr8:8085844 FLJ10661 0.59 9.11 0.45 7.8e-18 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs694739 0.894 rs11601860 chr11:64110422 A/T cg26898376 chr11:64110657 CCDC88B 0.37 7.01 0.36 1.36e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.56 9.54 0.46 3.2e-19 IgG glycosylation; LUSC cis rs9788682 0.747 rs2036533 chr15:78781687 G/A cg24631222 chr15:78858424 CHRNA5 0.65 8.65 0.43 2.2e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs6502050 0.723 rs11650635 chr17:80083816 T/C cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs6424115 0.867 rs34902309 chr1:24192200 A/G cg10978503 chr1:24200527 CNR2 -0.54 -12.93 -0.58 2.76e-31 Immature fraction of reticulocytes; LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg16606324 chr3:10149918 C3orf24 0.6 8.69 0.43 1.63e-16 Alzheimer's disease; LUSC cis rs3815700 1.000 rs8101356 chr19:33093402 C/T cg02997394 chr19:33096574 ANKRD27 0.79 8.95 0.44 2.44e-17 Eosinophilic esophagitis; LUSC cis rs4631830 1.000 rs4631830 chr10:51543344 C/T cg16070123 chr10:51489643 NA -0.48 -7.3 -0.37 2.1e-12 Prostate-specific antigen levels; LUSC cis rs11955175 1.000 rs78855960 chr5:40657221 C/G cg04002187 chr5:40835754 RPL37 0.65 5.67 0.3 3.07e-8 Bipolar disorder and schizophrenia; LUSC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg12288994 chr5:1860383 NA 0.3 6.6 0.34 1.63e-10 Cardiovascular disease risk factors; LUSC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg17524265 chr8:144659883 NAPRT1 -0.78 -9.01 -0.44 1.64e-17 Attention deficit hyperactivity disorder; LUSC cis rs7524258 0.900 rs6670323 chr1:7301947 C/A cg07173049 chr1:7289937 CAMTA1 0.32 6.6 0.34 1.58e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs62400317 0.826 rs12194628 chr6:45329376 G/C cg20913747 chr6:44695427 NA -0.48 -7.85 -0.39 5.56e-14 Total body bone mineral density; LUSC cis rs734999 0.545 rs10797436 chr1:2538349 G/A cg18932078 chr1:2524107 MMEL1 0.32 7.02 0.36 1.23e-11 Ulcerative colitis; LUSC cis rs7106204 0.668 rs7119198 chr11:24218267 A/G ch.11.24196551F chr11:24239977 NA 1.13 14.35 0.62 9.89e-37 Response to Homoharringtonine (cytotoxicity); LUSC cis rs61931739 0.500 rs11053274 chr12:34547605 G/A cg06521331 chr12:34319734 NA -0.43 -6.7 -0.34 9.01e-11 Morning vs. evening chronotype; LUSC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg25554036 chr4:6271136 WFS1 0.61 12.65 0.57 3.12e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.66 11.48 0.53 6.12e-26 Menarche (age at onset); LUSC cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.56 0.38 3.81e-13 Cognitive ability; LUSC cis rs68170813 0.605 rs75659533 chr7:107134987 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.46 -5.96 -0.31 6.37e-9 Coronary artery disease; LUSC cis rs7267979 1.000 rs6083805 chr20:25317356 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.09 -0.74 2.1e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.87 -0.4 5.15e-14 Height; LUSC trans rs2562456 0.833 rs516519 chr19:21481532 C/G cg00806126 chr19:22604979 ZNF98 0.4 6.2 0.32 1.67e-9 Pain; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.96e-29 Prudent dietary pattern; LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC cis rs9287719 0.967 rs6748036 chr2:10717489 C/T cg00105475 chr2:10696890 NA 0.39 6.51 0.34 2.75e-10 Prostate cancer; LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.25 -0.52 4.08e-25 Alzheimer's disease; LUSC cis rs7589342 0.536 rs1367404 chr2:106386865 G/T cg09152813 chr2:106391379 NCK2 -0.37 -6.12 -0.32 2.69e-9 Addiction; LUSC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg08392591 chr16:89556376 ANKRD11 0.43 6.64 0.34 1.26e-10 Multiple myeloma (IgH translocation); LUSC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.59 -7.53 -0.38 4.68e-13 Body mass index (adult); LUSC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.0 -0.4 2.12e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7177699 0.526 rs7165042 chr15:79123338 C/G cg15571903 chr15:79123663 NA 0.34 6.34 0.33 7.41e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9677476 0.863 rs3731775 chr2:232063578 G/A cg07929768 chr2:232055508 NA 0.37 6.86 0.35 3.44e-11 Food antigen IgG levels; LUSC cis rs6987853 0.787 rs2923442 chr8:42435493 T/C cg09913449 chr8:42400586 C8orf40 0.53 9.23 0.45 3.26e-18 Mean corpuscular hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12509004 chr7:129691220 ZC3HC1 0.39 6.02 0.31 4.65e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg05347473 chr6:146136440 FBXO30 0.5 8.43 0.42 1.07e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs7937682 0.824 rs577044 chr11:111490420 G/T cg18187862 chr3:45730750 SACM1L 0.52 6.79 0.35 5.18e-11 Primary sclerosing cholangitis; LUSC cis rs2639990 0.744 rs640261 chr18:72905808 C/T cg03972071 chr18:72917163 ZADH2 0.51 5.91 0.31 8.52e-9 Vascular endothelial growth factor levels; LUSC cis rs472402 0.580 rs3733773 chr5:6652252 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.45 -6.54 -0.34 2.24e-10 Response to amphetamines; LUSC cis rs9427116 0.702 rs884618 chr1:154601157 A/G cg17218026 chr1:154582156 ADAR 0.56 9.84 0.47 3.08e-20 Blood protein levels; LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 12.17 0.55 1.93e-28 Platelet count; LUSC cis rs981844 0.816 rs62325145 chr4:154725687 G/C cg14289246 chr4:154710475 SFRP2 0.48 6.09 0.32 3.15e-9 Response to statins (LDL cholesterol change); LUSC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg11062466 chr8:58055876 NA 0.42 5.66 0.3 3.32e-8 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs9816226 1.000 rs61587156 chr3:185831583 T/G cg00760338 chr3:185826511 ETV5 -0.66 -8.18 -0.41 6.13e-15 Obesity;Body mass index; LUSC cis rs11098499 0.954 rs12507964 chr4:120413061 T/A cg09307838 chr4:120376055 NA 0.79 11.8 0.54 4.37e-27 Corneal astigmatism; LUSC cis rs3806843 0.576 rs246049 chr5:140327590 T/G cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6456156 0.586 rs12528323 chr6:167461645 A/G cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11644478 chr21:40555479 PSMG1 0.84 14.91 0.63 6.63e-39 Cognitive function; LUSC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg05729581 chr11:3078854 CARS -0.58 -8.77 -0.43 9.5e-17 Longevity; LUSC cis rs68170813 0.559 rs74925723 chr7:106954536 G/C cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC cis rs9527 0.590 rs7087459 chr10:104790999 T/C cg05855489 chr10:104503620 C10orf26 0.53 8.12 0.41 9.19e-15 Arsenic metabolism; LUSC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg04398451 chr17:18023971 MYO15A 0.57 9.5 0.46 4.25e-19 Total body bone mineral density; LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg02820958 chr19:7099040 NA -0.58 -6.2 -0.32 1.66e-9 Schizophrenia; LUSC cis rs981844 0.890 rs56184506 chr4:154685889 G/T cg14289246 chr4:154710475 SFRP2 0.55 7.13 0.36 6.34e-12 Response to statins (LDL cholesterol change); LUSC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg21644426 chr2:191273491 MFSD6 0.59 9.44 0.46 6.42e-19 Pulse pressure; LUSC cis rs6840360 0.901 rs4696293 chr4:152707380 C/T cg22705602 chr4:152727874 NA 0.27 5.73 0.3 2.28e-8 Intelligence (multi-trait analysis); LUSC cis rs2398893 0.774 rs10993047 chr9:96846500 C/T cg14459158 chr9:96720562 NA -0.32 -6.02 -0.31 4.68e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg24642844 chr7:1081250 C7orf50 -0.63 -9.18 -0.45 4.46e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs4720118 1.000 rs11972278 chr7:33431364 C/T cg23247845 chr10:3679085 NA -0.33 -5.95 -0.31 6.91e-9 Leprosy; LUSC trans rs7829975 0.567 rs6601273 chr8:8796519 T/G cg27411982 chr8:10470053 RP1L1 -0.39 -6.39 -0.33 5.66e-10 Mood instability; LUSC cis rs11112613 0.713 rs73184081 chr12:105951745 C/T cg03607813 chr12:105948248 NA 0.79 11.96 0.55 1.13e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs9747201 1.000 rs58119191 chr17:80155329 T/C cg07393940 chr7:158741817 NA 0.54 8.75 0.43 1.06e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7677751 0.806 rs17084051 chr4:55087581 C/A cg17187183 chr4:55093834 PDGFRA 0.38 5.83 0.3 1.3e-8 Corneal astigmatism; LUSC cis rs7681440 0.874 rs7687945 chr4:90764699 C/T cg01966878 chr4:90757139 SNCA -0.36 -6.22 -0.32 1.52e-9 Dementia with Lewy bodies; LUSC cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg08999081 chr20:33150536 PIGU 0.55 11.06 0.52 1.88e-24 Coronary artery disease; LUSC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg24977027 chr2:88469347 THNSL2 0.56 5.9 0.31 8.7e-9 Plasma clusterin levels; LUSC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg17264618 chr3:40429014 ENTPD3 -0.32 -7.07 -0.36 8.91e-12 Renal cell carcinoma; LUSC cis rs9815354 0.680 rs73073266 chr3:42021116 A/G cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs7215564 0.908 rs35725122 chr17:78663275 A/T cg23238734 chr17:78661607 RPTOR 0.47 6.1 0.32 2.98e-9 Myopia (pathological); LUSC cis rs75920871 0.528 rs1531707 chr11:116944712 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.48 -0.33 3.25e-10 Subjective well-being; LUSC cis rs7106204 0.748 rs28552633 chr11:24207518 A/C ch.11.24196551F chr11:24239977 NA 1.1 13.55 0.6 1.19e-33 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1215050 0.791 rs1506438 chr4:98789542 C/T cg05340658 chr4:99064831 C4orf37 0.43 6.89 0.35 2.75e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg14092988 chr3:52407081 DNAH1 0.31 6.12 0.32 2.62e-9 Bipolar disorder; LUSC cis rs8078723 1.000 rs8070454 chr17:38160754 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.89 -0.35 2.81e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg06640241 chr16:89574553 SPG7 0.68 10.74 0.51 2.57e-23 Multiple myeloma (IgH translocation); LUSC cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg01884057 chr2:25150051 NA 0.44 10.17 0.49 2.41e-21 Body mass index; LUSC cis rs1788820 0.957 rs1652375 chr18:21109269 T/C cg14672496 chr18:21087552 C18orf8 0.43 6.8 0.35 4.81e-11 Body mass index; LUSC cis rs2274273 0.638 rs17672364 chr14:55705904 G/T cg04306507 chr14:55594613 LGALS3 0.48 9.48 0.46 4.9e-19 Protein biomarker; LUSC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg18225595 chr11:63971243 STIP1 0.51 6.33 0.33 7.83e-10 Mean platelet volume; LUSC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03517284 chr6:25882590 NA -0.69 -11.24 -0.52 4.6e-25 Intelligence (multi-trait analysis); LUSC trans rs208520 0.690 rs3846808 chr6:66818604 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.63 -0.69 1.27e-49 Exhaled nitric oxide output; LUSC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.88 0.35 3.02e-11 Intelligence (multi-trait analysis); LUSC trans rs561341 1.000 rs2470267 chr17:30274132 G/A cg20587970 chr11:113659929 NA -1.12 -15.21 -0.64 4.59e-40 Hip circumference adjusted for BMI; LUSC cis rs10876993 0.928 rs10877008 chr12:58103592 A/G cg15848620 chr12:58087721 OS9 -0.56 -8.06 -0.4 1.34e-14 Celiac disease or Rheumatoid arthritis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02123667 chr8:127570702 FAM84B -0.39 -6.5 -0.34 2.99e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs804280 0.543 rs13261205 chr8:11791216 A/G cg08975724 chr8:8085496 FLJ10661 0.5 7.16 0.36 5.12e-12 Myopia (pathological); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10551016 chr22:41252963 ST13;XPNPEP3 -0.52 -6.59 -0.34 1.68e-10 Bipolar disorder and schizophrenia; LUSC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg08564027 chr20:61660810 NA 0.9 17.01 0.68 3.71e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs9467773 1.000 rs6456734 chr6:26566965 G/T cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC cis rs9811920 0.535 rs792833 chr3:99475268 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.3 5.92 0.31 7.82e-9 Axial length; LUSC cis rs8099014 0.861 rs4245270 chr18:56112854 A/G cg12907477 chr18:56117327 MIR122 0.43 6.59 0.34 1.74e-10 Platelet count; LUSC cis rs3849570 0.925 rs6798680 chr3:81905441 C/A cg07356753 chr3:81810745 GBE1 -0.68 -11.34 -0.53 2.02e-25 Waist circumference;Body mass index; LUSC cis rs10754283 0.967 rs2185195 chr1:90106697 T/C cg21401794 chr1:90099060 LRRC8C 0.65 9.74 0.47 6.91e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg15556689 chr8:8085844 FLJ10661 -0.56 -8.77 -0.43 9.01e-17 Neuroticism; LUSC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg14829155 chr15:31115871 NA -0.56 -7.81 -0.39 7.42e-14 Huntington's disease progression; LUSC cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg13010199 chr12:38710504 ALG10B 0.69 11.59 0.54 2.49e-26 Heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10433104 chr11:18417767 LDHA 0.54 7.73 0.39 1.29e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg15704280 chr7:45808275 SEPT13 -0.85 -14.27 -0.62 2.06e-36 Height; LUSC cis rs11078917 1 rs11078917 chr17:37746359 A/C cg07936489 chr17:37558343 FBXL20 -0.55 -7.34 -0.37 1.61e-12 Mean corpuscular volume; LUSC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg12365402 chr11:9010492 NRIP3 0.43 7.88 0.4 4.55e-14 Hemoglobin concentration; LUSC cis rs7312933 0.558 rs1796394 chr12:42826359 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.82 -0.35 4.27e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12122100 0.774 rs12124149 chr1:146523897 G/T cg03526459 chr1:146549940 NA -0.34 -5.77 -0.3 1.83e-8 HIV-1 control; LUSC cis rs2730245 0.618 rs859781 chr7:158661758 G/A cg11984989 chr7:158649758 WDR60 1.08 22.66 0.78 1.61e-69 Height; LUSC cis rs16854884 0.632 rs35362423 chr3:143687441 C/A cg06585982 chr3:143692056 C3orf58 0.45 6.83 0.35 4.09e-11 Economic and political preferences (feminism/equality); LUSC cis rs9467711 0.606 rs9366655 chr6:26377385 C/G cg09904177 chr6:26538194 HMGN4 -0.71 -6.76 -0.35 6.06e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg07167872 chr1:205819463 PM20D1 0.96 21.23 0.76 6.16e-64 Menarche (age at onset); LUSC cis rs921665 0.680 rs4854132 chr2:3199378 T/A cg16434511 chr2:3151078 NA -0.62 -6.6 -0.34 1.63e-10 World class endurance athleticism; LUSC cis rs5758511 0.508 rs28715885 chr22:42441091 T/G cg12850546 chr22:42539477 CYP2D7P1 -0.54 -6.34 -0.33 7.27e-10 Birth weight; LUSC cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.02e-21 Bladder cancer; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg02978959 chr19:57791520 ZNF460 0.4 6.01 0.31 4.75e-9 Eotaxin levels; LUSC cis rs6772849 0.930 rs1962040 chr3:128324161 G/A cg16766828 chr3:128327626 NA -0.31 -5.77 -0.3 1.8e-8 Monocyte percentage of white cells;Monocyte count; LUSC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg18512352 chr11:47633146 NA -0.48 -9.63 -0.47 1.55e-19 Subjective well-being; LUSC cis rs4319547 0.774 rs10773394 chr12:123124778 C/A cg23029597 chr12:123009494 RSRC2 -0.59 -8.5 -0.42 6.41e-16 Body mass index; LUSC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.76e-13 Schizophrenia; LUSC cis rs72634258 0.740 rs6665452 chr1:8172492 A/T cg00042356 chr1:8021962 PARK7 -0.54 -6.55 -0.34 2.13e-10 Inflammatory bowel disease; LUSC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs354225 0.544 rs10208225 chr2:54806049 G/A cg01766943 chr2:54829624 SPTBN1 0.48 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg18225595 chr11:63971243 STIP1 0.5 6.19 0.32 1.8e-9 Mean platelet volume; LUSC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg11764359 chr7:65958608 NA 0.69 10.69 0.5 3.99e-23 Aortic root size; LUSC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg08888203 chr3:10149979 C3orf24 0.48 7.21 0.37 3.81e-12 Alzheimer's disease; LUSC cis rs4654899 0.865 rs61779073 chr1:21398740 C/A cg01072550 chr1:21505969 NA -0.52 -7.71 -0.39 1.42e-13 Superior frontal gyrus grey matter volume; LUSC cis rs9329221 1.000 rs9329221 chr8:10240202 G/T cg27411982 chr8:10470053 RP1L1 0.45 7.26 0.37 2.7e-12 Neuroticism; LUSC cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg09307838 chr4:120376055 NA 0.78 11.07 0.52 1.86e-24 Corneal astigmatism; LUSC trans rs629535 0.773 rs630235 chr8:70033529 T/G cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs7829975 0.508 rs1594437 chr8:8825875 T/C cg08975724 chr8:8085496 FLJ10661 0.38 5.64 0.3 3.54e-8 Mood instability; LUSC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.63 9.62 0.47 1.65e-19 Height; LUSC cis rs7937682 0.632 rs11608193 chr11:111732215 T/C cg09085632 chr11:111637200 PPP2R1B 0.93 12.34 0.56 4.58e-29 Primary sclerosing cholangitis; LUSC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg11764359 chr7:65958608 NA -0.6 -8.92 -0.44 3.1e-17 Aortic root size; LUSC cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg23711669 chr6:146136114 FBXO30 -0.78 -14.2 -0.61 4.07e-36 Lobe attachment (rater-scored or self-reported); LUSC trans rs7824557 0.806 rs10503418 chr8:11118983 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.91 -0.44 3.34e-17 Retinal vascular caliber; LUSC cis rs709400 0.628 rs6575983 chr14:103869849 C/G cg12935359 chr14:103987150 CKB -0.47 -7.59 -0.38 3.33e-13 Body mass index; LUSC trans rs724744 0.712 rs1737223 chr6:22355948 C/T cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.51 0.38 5.61e-13 Prudent dietary pattern; LUSC cis rs17270561 0.609 rs9358873 chr6:25731783 C/T cg17691542 chr6:26056736 HIST1H1C 0.57 7.77 0.39 9.81e-14 Iron status biomarkers; LUSC cis rs67460515 0.892 rs11718905 chr3:161051793 G/A cg03342759 chr3:160939853 NMD3 -0.52 -7.45 -0.38 7.85e-13 Parkinson's disease; LUSC cis rs6542838 0.583 rs7565819 chr2:99519265 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.52 -6.92 -0.35 2.37e-11 Fear of minor pain; LUSC cis rs10489202 0.632 rs275143 chr1:168056724 A/G cg24449463 chr1:168025552 DCAF6 -0.76 -12.38 -0.56 3.09e-29 Schizophrenia; LUSC cis rs9346649 0.630 rs4235913 chr6:168491697 T/C cg02770688 chr6:168491649 NA 0.48 9.05 0.44 1.23e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs4901869 0.966 rs9972208 chr14:59336116 C/T cg02291164 chr14:59296302 NA 0.57 10.88 0.51 8.53e-24 Panic disorder; LUSC cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg04455712 chr21:45112962 RRP1B 0.47 9.03 0.44 1.42e-17 Mean corpuscular volume; LUSC cis rs4363385 0.719 rs6664411 chr1:152932857 T/C cg07796016 chr1:152779584 LCE1C -0.47 -6.7 -0.34 8.81e-11 Inflammatory skin disease; LUSC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.12 -0.41 8.84e-15 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -5.73 -0.3 2.26e-8 Height; LUSC cis rs568617 0.626 rs78028320 chr11:65582015 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.58 6.51 0.34 2.75e-10 Crohn's disease; LUSC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg15556689 chr8:8085844 FLJ10661 -0.67 -11.47 -0.53 6.58e-26 Mood instability; LUSC cis rs7605827 0.930 rs7568874 chr2:15546361 T/C cg19274914 chr2:15703543 NA 0.46 8.81 0.43 6.85e-17 Educational attainment (years of education); LUSC cis rs11039100 1.000 rs12362071 chr11:5828450 T/C cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1215050 0.791 rs13107606 chr4:98823187 C/A cg05340658 chr4:99064831 C4orf37 0.43 6.83 0.35 4.08e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2742234 0.541 rs10899779 chr10:43723976 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 7.01 0.36 1.3e-11 Hirschsprung disease; LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg08470875 chr2:26401718 FAM59B 0.71 9.7 0.47 9.2e-20 Gut microbiome composition (summer); LUSC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg24562669 chr7:97807699 LMTK2 0.33 5.81 0.3 1.42e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs826838 0.967 rs826855 chr12:39114888 T/C cg26384229 chr12:38710491 ALG10B -0.83 -15.53 -0.65 2.62e-41 Heart rate; LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg14092988 chr3:52407081 DNAH1 0.33 6.39 0.33 5.69e-10 Bipolar disorder; LUSC cis rs1150668 0.699 rs2394049 chr6:28239681 A/G cg21251018 chr6:28226885 NKAPL 0.33 6.46 0.33 3.62e-10 Pubertal anthropometrics; LUSC cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg13072238 chr3:49761600 GMPPB -0.66 -8.05 -0.4 1.51e-14 Menarche (age at onset); LUSC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1865721 0.656 rs727894 chr18:73137117 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -8.94 -0.44 2.65e-17 Intelligence; LUSC cis rs2425143 1.000 rs12480408 chr20:34234800 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.24 -0.32 1.33e-9 Blood protein levels; LUSC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg18190219 chr22:46762943 CELSR1 -0.71 -6.87 -0.35 3.12e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs7843479 1.000 rs10503715 chr8:21850687 G/A cg17168535 chr8:21777572 XPO7 0.64 9.54 0.46 3.04e-19 Mean corpuscular volume; LUSC cis rs9811920 0.732 rs7613864 chr3:99602470 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 7.44 0.38 8.62e-13 Axial length; LUSC cis rs3087591 0.614 rs3785955 chr17:29647802 C/T cg24425628 chr17:29625626 OMG;NF1 0.46 6.85 0.35 3.48e-11 Hip circumference; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.65 9.88 0.48 2.39e-20 Lymphocyte counts; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg22963979 chr7:1858916 MAD1L1 0.73 12.58 0.57 5.76e-30 Bipolar disorder and schizophrenia; LUSC cis rs7100689 0.646 rs7081889 chr10:82165427 C/A cg00277334 chr10:82204260 NA -0.49 -7.22 -0.37 3.48e-12 Post bronchodilator FEV1; LUSC trans rs11098499 0.954 rs17006190 chr4:120418838 C/G cg25214090 chr10:38739885 LOC399744 0.55 8.2 0.41 5.35e-15 Corneal astigmatism; LUSC cis rs7582180 0.629 rs4851295 chr2:100945605 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg25767906 chr1:53392781 SCP2 0.39 6.78 0.35 5.63e-11 Monocyte count; LUSC cis rs7246657 0.943 rs10426666 chr19:37828514 C/G cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg23758822 chr17:41437982 NA 1.04 19.58 0.73 2.23e-57 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24389389 chr4:141075404 MAML3 -0.45 -6.81 -0.35 4.41e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg03354898 chr7:1950403 MAD1L1 -0.38 -7.66 -0.39 2.02e-13 Bipolar disorder and schizophrenia; LUSC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg20406979 chr6:167373233 NA 0.26 6.15 0.32 2.25e-9 Crohn's disease; LUSC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg02569458 chr12:86230093 RASSF9 -0.48 -8.03 -0.4 1.63e-14 Major depressive disorder; LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.39 0.67 1.04e-44 Platelet count; LUSC cis rs9807989 0.839 rs10204137 chr2:102968212 A/G cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06452642 chr19:13875641 MRI1 -0.49 -6.0 -0.31 4.99e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg18876405 chr7:65276391 NA -0.54 -8.5 -0.42 6.21e-16 Aortic root size; LUSC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg17724175 chr1:150552817 MCL1 0.37 6.75 0.35 6.71e-11 Tonsillectomy; LUSC cis rs7824557 0.564 rs2736302 chr8:11236419 T/C cg27411982 chr8:10470053 RP1L1 -0.37 -5.9 -0.31 8.72e-9 Retinal vascular caliber; LUSC cis rs9653442 0.545 rs12987212 chr2:100761156 C/T cg07810366 chr2:100720526 AFF3 -0.45 -7.75 -0.39 1.13e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1577917 0.740 rs9353320 chr6:86244848 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 9.09 0.45 9.22e-18 Response to antipsychotic treatment; LUSC cis rs4293296 0.525 rs1955458 chr14:54827524 A/C cg02257953 chr14:54816093 NA 0.46 6.64 0.34 1.29e-10 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg00684032 chr4:1343700 KIAA1530 0.34 6.19 0.32 1.76e-9 Obesity-related traits; LUSC cis rs7904368 0.951 rs7905776 chr10:16853609 C/T cg14835575 chr10:16859367 RSU1 0.64 8.54 0.42 4.67e-16 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg08280861 chr8:58055591 NA 0.55 6.51 0.34 2.79e-10 Developmental language disorder (linguistic errors); LUSC cis rs2820315 0.867 rs2819346 chr1:201882087 A/C cg10061532 chr1:201886748 LMOD1 0.29 6.9 0.35 2.67e-11 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs17270561 0.779 rs78589800 chr6:25883500 C/G cg17691542 chr6:26056736 HIST1H1C 0.83 11.19 0.52 6.72e-25 Iron status biomarkers; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg19318889 chr4:1322082 MAEA 0.48 7.69 0.39 1.68e-13 Obesity-related traits; LUSC cis rs2797160 1.000 rs1739380 chr6:126012858 T/C cg05901451 chr6:126070800 HEY2 0.57 8.66 0.43 2.04e-16 Endometrial cancer; LUSC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7267979 1.000 rs2482928 chr20:25331530 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.18 -0.71 7.93e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7618501 1.000 rs2271960 chr3:49878078 A/G cg13072238 chr3:49761600 GMPPB 0.41 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); LUSC cis rs12711979 0.509 rs10187740 chr2:3823965 A/G cg17052675 chr2:3827356 NA 0.83 20.03 0.74 3.54e-59 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.85 0.39 5.56e-14 Colorectal cancer; LUSC cis rs7759001 0.857 rs4713094 chr6:27373078 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 2e-8 Glomerular filtration rate (creatinine); LUSC cis rs7582180 0.629 rs2164847 chr2:100958715 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.7 -0.43 1.49e-16 Intelligence (multi-trait analysis); LUSC cis rs6456156 0.565 rs6456153 chr6:167472167 T/C cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs6489785 0.710 rs3213566 chr12:121222578 T/C cg02419362 chr12:121203948 SPPL3 0.41 7.34 0.37 1.6e-12 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg06601766 chr17:61851465 DDX42;CCDC47 -0.42 -6.44 -0.33 4.13e-10 Prudent dietary pattern; LUSC cis rs9768139 0.708 rs10262596 chr7:158114495 G/A cg25566285 chr7:158114605 PTPRN2 0.35 6.53 0.34 2.52e-10 Calcium levels; LUSC cis rs2281845 0.507 rs1536127 chr1:201086894 C/A cg22815214 chr1:201083145 CACNA1S 0.46 6.54 0.34 2.33e-10 Permanent tooth development; LUSC cis rs4654899 0.643 rs1408409 chr1:21089781 T/C cg01072550 chr1:21505969 NA -0.47 -7.05 -0.36 1.03e-11 Superior frontal gyrus grey matter volume; LUSC trans rs11165623 0.543 rs60982887 chr1:96989155 T/G cg10631902 chr5:14652156 NA -0.43 -6.18 -0.32 1.88e-9 Hip circumference;Waist circumference; LUSC trans rs911555 0.755 rs12432803 chr14:103930032 C/T cg17675199 chr6:35436792 RPL10A -0.43 -6.42 -0.33 4.61e-10 Intelligence (multi-trait analysis); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg08525481 chr20:61436809 OGFR 0.39 5.95 0.31 6.87e-9 Schizophrenia; LUSC trans rs62238980 0.614 rs79061246 chr22:32468866 G/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs9311676 0.656 rs11130638 chr3:58405947 A/G cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.1e-10 Systemic lupus erythematosus; LUSC trans rs45509595 0.822 rs200484 chr6:27775674 A/G cg06606381 chr12:133084897 FBRSL1 -0.74 -7.4 -0.38 1.1e-12 Breast cancer; LUSC cis rs2282300 0.702 rs2211018 chr11:30330079 C/T cg25418670 chr11:30344373 C11orf46 0.64 9.23 0.45 3.29e-18 Morning vs. evening chronotype; LUSC cis rs12530845 1.000 rs12537555 chr7:135334061 G/A cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs9467773 1.000 rs6940188 chr6:26562029 G/C cg05738196 chr6:26577821 NA 0.83 16.17 0.66 7.47e-44 Intelligence (multi-trait analysis); LUSC cis rs3818285 0.556 rs944966 chr10:111658334 C/G cg00817464 chr10:111662876 XPNPEP1 -0.59 -8.5 -0.42 6.35e-16 Superior crus of antihelix expression; LUSC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg04155289 chr7:94953770 PON1 -0.35 -6.05 -0.31 3.82e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7804356 1.000 rs10486483 chr7:26892440 A/G cg03456212 chr7:26904342 SKAP2 0.53 6.32 0.33 8.36e-10 Type 1 diabetes; LUSC cis rs6840360 1.000 rs4696109 chr4:152668785 A/C cg22705602 chr4:152727874 NA -0.28 -6.07 -0.32 3.49e-9 Intelligence (multi-trait analysis); LUSC cis rs6484504 0.532 rs7121949 chr11:31288160 G/T cg06552810 chr11:31128660 NA -0.39 -6.86 -0.35 3.38e-11 Red blood cell count; LUSC cis rs2835872 0.965 rs2154553 chr21:39004501 G/A cg20424643 chr21:39039972 KCNJ6 -0.4 -6.09 -0.32 3.15e-9 Electroencephalographic traits in alcoholism; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs8113142 0.651 rs61150903 chr19:29093321 A/G cg04546413 chr19:29218101 NA 0.41 5.74 0.3 2.15e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs73206853 0.660 rs12313068 chr12:110597304 C/T cg12870014 chr12:110450643 ANKRD13A 0.51 6.92 0.35 2.38e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg08888203 chr3:10149979 C3orf24 0.59 8.1 0.41 1.08e-14 Alzheimer's disease; LUSC cis rs6700896 0.500 rs11208692 chr1:66107946 A/C cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.36 0.33 6.62e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4969178 0.965 rs4969179 chr17:76391454 A/C cg20026190 chr17:76395443 PGS1 0.44 7.81 0.39 7.25e-14 HDL cholesterol levels; LUSC cis rs7572644 0.581 rs35463245 chr2:28000724 C/G cg27432699 chr2:27873401 GPN1 0.55 7.05 0.36 1.01e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs12317459 0.591 rs11609468 chr12:83206927 T/C cg10237817 chr1:154519846 TDRD10 0.3 6.35 0.33 6.89e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 3.01e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg22920501 chr2:26401640 FAM59B -0.74 -10.35 -0.49 5.96e-22 Gut microbiome composition (summer); LUSC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg17279839 chr7:150038598 RARRES2 -0.43 -6.57 -0.34 1.92e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6163 0.540 rs11191385 chr10:104513049 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.48 -6.57 -0.34 1.94e-10 Waist circumference;Hip circumference; LUSC cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg25427524 chr10:38739819 LOC399744 0.62 11.01 0.52 2.9e-24 Extrinsic epigenetic age acceleration; LUSC cis rs11711311 1.000 rs34475696 chr3:113458293 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg18402987 chr7:1209562 NA 0.67 7.08 0.36 8.56e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC trans rs17641971 0.862 rs341817 chr8:50023600 A/C cg15678142 chr1:167411538 CD247 0.4 6.12 0.32 2.64e-9 Blood metabolite levels; LUSC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg17971929 chr21:40555470 PSMG1 0.75 11.77 0.54 5.39e-27 Cognitive function; LUSC cis rs6845621 0.901 rs10489055 chr4:18933156 A/G cg12196642 chr4:18937545 NA -0.37 -6.88 -0.35 2.92e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2463822 1.000 rs1881534 chr11:62085083 A/G cg06239285 chr11:62104954 ASRGL1 0.95 10.4 0.49 3.96e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg06618935 chr21:46677482 NA 0.37 7.63 0.39 2.51e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.67 -0.39 1.93e-13 Height; LUSC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.86 0.47 2.61e-20 Major depressive disorder; LUSC cis rs983392 0.776 rs2278867 chr11:59943109 A/T cg02771260 chr11:59836817 MS4A3 -0.37 -5.88 -0.31 1.01e-8 Alzheimer's disease (late onset); LUSC cis rs9611565 0.592 rs4822040 chr22:41963553 C/G cg06634786 chr22:41940651 POLR3H -0.5 -5.98 -0.31 5.72e-9 Vitiligo; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12216983 chr12:122751217 VPS33A -0.41 -5.96 -0.31 6.44e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7586879 0.675 rs7600421 chr2:25075876 T/G cg01884057 chr2:25150051 NA 0.35 7.01 0.36 1.36e-11 Body mass index; LUSC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg00599273 chr12:58146742 CDK4 0.31 5.92 0.31 8.04e-9 Multiple sclerosis; LUSC cis rs3857536 0.611 rs6927407 chr6:66870010 T/C cg07460842 chr6:66804631 NA -0.52 -7.4 -0.38 1.13e-12 Blood trace element (Cu levels); LUSC cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg04518342 chr5:131593106 PDLIM4 -0.36 -6.56 -0.34 2.01e-10 Blood metabolite levels; LUSC cis rs7246657 1.000 rs35398388 chr19:37740358 A/G cg23950597 chr19:37808831 NA -0.61 -6.99 -0.36 1.53e-11 Coronary artery calcification; LUSC cis rs7944584 0.879 rs11039182 chr11:47346723 T/C cg20307385 chr11:47447363 PSMC3 0.75 10.13 0.48 3.4e-21 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1483890 0.723 rs1843046 chr3:69410614 C/A cg22125112 chr3:69402811 FRMD4B 0.4 5.67 0.3 3.06e-8 Resting heart rate; LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg11645453 chr3:52864694 ITIH4 0.36 8.21 0.41 4.91e-15 Bipolar disorder; LUSC cis rs79149102 0.579 rs12593476 chr15:75282092 A/C cg17294928 chr15:75287854 SCAMP5 -0.68 -5.83 -0.3 1.34e-8 Lung cancer; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs67539049 1.000 rs67539049 chr8:11307311 G/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.4 -6.08 -0.32 3.33e-9 Itch intensity from mosquito bite; LUSC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.62 -8.05 -0.4 1.49e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg17845761 chr1:175162550 KIAA0040 0.31 5.93 0.31 7.53e-9 Alcohol dependence; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg06887542 chr12:48357506 TMEM106C -0.48 -6.04 -0.31 4.16e-9 Neuroticism; LUSC cis rs1559088 0.501 rs35492529 chr19:33597495 C/G cg17764715 chr19:33622953 WDR88 0.57 6.16 0.32 2.1e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs853679 0.517 rs9380047 chr6:28037893 G/T cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC trans rs62103177 0.810 rs3902996 chr18:77630571 A/G cg05926928 chr17:57297772 GDPD1 1.43 16.18 0.66 6.92e-44 Opioid sensitivity; LUSC cis rs4780401 0.609 rs35649585 chr16:11813899 G/A cg01061890 chr16:11836724 TXNDC11 -0.56 -8.58 -0.43 3.56e-16 Rheumatoid arthritis; LUSC cis rs7927771 0.524 rs10742820 chr11:47781057 C/T cg20307385 chr11:47447363 PSMC3 -0.44 -6.61 -0.34 1.51e-10 Subjective well-being; LUSC cis rs77741769 0.571 rs34009825 chr12:121326183 A/G cg02419362 chr12:121203948 SPPL3 0.45 8.24 0.41 3.89e-15 Mean corpuscular volume; LUSC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg19748678 chr4:122722346 EXOSC9 0.5 7.67 0.39 1.86e-13 Type 2 diabetes; LUSC cis rs10911251 0.508 rs10797854 chr1:183106739 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.53 0.5 1.4e-22 Colorectal cancer; LUSC cis rs7264396 0.677 rs6060553 chr20:34267386 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.36 -0.46 1.18e-18 Total cholesterol levels; LUSC cis rs950881 0.932 rs10189154 chr2:102937544 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.37 0.33 6.4e-10 Allergy; LUSC cis rs3744061 0.530 rs8182300 chr17:74650608 T/C cg27546012 chr17:74684504 MXRA7 -0.39 -6.74 -0.35 7.04e-11 Retinal arteriolar caliber; LUSC trans rs72674100 1.000 rs7681234 chr4:97964425 T/A cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg12463550 chr7:65579703 CRCP -0.47 -7.07 -0.36 9.33e-12 Aortic root size; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -9.16 -0.45 5.27e-18 Bipolar disorder and schizophrenia; LUSC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg17971929 chr21:40555470 PSMG1 0.8 13.37 0.59 6.01e-33 Cognitive function; LUSC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.33 -0.37 1.73e-12 Alzheimer's disease (late onset); LUSC cis rs72781680 0.898 rs56413706 chr2:24086961 G/A cg20701182 chr2:24300061 SF3B14 0.73 7.33 0.37 1.74e-12 Lymphocyte counts; LUSC cis rs9486715 0.867 rs9373907 chr6:96981189 G/A cg06623918 chr6:96969491 KIAA0776 0.92 16.83 0.68 1.89e-46 Headache; LUSC cis rs11122272 0.735 rs2749723 chr1:231493302 A/G cg06096015 chr1:231504339 EGLN1 0.56 9.84 0.47 3.07e-20 Hemoglobin concentration; LUSC cis rs11039100 1.000 rs12366070 chr11:5828394 C/T cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs868036 0.756 rs2241421 chr15:68082825 G/A cg08079166 chr15:68083412 MAP2K5 0.4 8.42 0.42 1.13e-15 Restless legs syndrome; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg07362569 chr17:61921086 SMARCD2 0.37 7.31 0.37 1.98e-12 Prudent dietary pattern; LUSC cis rs6733011 0.622 rs12712036 chr2:99462711 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.41 -5.66 -0.3 3.23e-8 Bipolar disorder; LUSC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg06640241 chr16:89574553 SPG7 0.98 20.4 0.74 1.16e-60 Multiple myeloma (IgH translocation); LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg13256891 chr4:100009986 ADH5 0.44 6.69 0.34 9.19e-11 Alcohol dependence; LUSC trans rs11992162 1.000 rs7460395 chr8:11835375 C/T cg15556689 chr8:8085844 FLJ10661 0.46 6.34 0.33 7.4e-10 Monocyte count; LUSC cis rs7615316 0.816 rs13065075 chr3:142265166 T/C cg16271453 chr3:142027066 XRN1 -0.38 -6.59 -0.34 1.7e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg13047869 chr3:10149882 C3orf24 0.44 6.71 0.34 8.55e-11 Alzheimer's disease; LUSC cis rs9462027 0.628 rs9357181 chr6:34673833 C/T cg07306190 chr6:34760872 UHRF1BP1 0.36 6.34 0.33 7.36e-10 Systemic lupus erythematosus; LUSC cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.17 -0.37 4.99e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.592 rs708140 chr12:33719563 G/A cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg12863693 chr15:85201151 NMB 0.39 8.16 0.41 6.9e-15 Schizophrenia; LUSC cis rs4285028 0.747 rs12634032 chr3:121524575 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.33 -0.56 4.69e-29 Multiple sclerosis; LUSC cis rs7582180 0.591 rs12991577 chr2:101010867 C/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.64 -0.43 2.34e-16 Intelligence (multi-trait analysis); LUSC cis rs7568458 0.684 rs7608074 chr2:85809703 T/G cg23752985 chr2:85803571 VAMP8 0.34 6.51 0.34 2.73e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs17253792 0.822 rs7150841 chr14:56088986 T/C cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs9457247 0.934 rs2345571 chr6:167403400 T/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg22535103 chr8:58192502 C8orf71 -0.74 -7.67 -0.39 1.95e-13 Developmental language disorder (linguistic errors); LUSC cis rs9467773 1.000 rs9467778 chr6:26534743 T/C cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.86e-18 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.66 0.47 1.25e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg11632617 chr15:75315747 PPCDC -0.54 -7.01 -0.36 1.29e-11 Blood trace element (Zn levels); LUSC cis rs983392 0.719 rs610932 chr11:59939307 T/G cg02771260 chr11:59836817 MS4A3 0.36 6.05 0.31 3.86e-9 Alzheimer's disease (late onset); LUSC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg27532560 chr4:187881888 NA -0.37 -6.08 -0.32 3.33e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2439831 0.850 rs28696802 chr15:44140395 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.91 0.35 2.39e-11 Lung cancer in ever smokers; LUSC cis rs501916 0.634 rs1561480 chr15:48070050 C/G cg16110827 chr15:48056943 SEMA6D -0.38 -5.91 -0.31 8.52e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC trans rs57221529 0.709 rs72703090 chr5:598314 C/T cg25482853 chr8:67687455 SGK3 1.12 15.85 0.66 1.36e-42 Lung disease severity in cystic fibrosis; LUSC cis rs238295 0.805 rs6053525 chr20:5577000 C/T cg15842884 chr20:5591925 RP5-1022P6.2 -0.44 -5.94 -0.31 7.34e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs10992471 0.528 rs3780347 chr9:95266812 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.2 -0.32 1.69e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4443100 0.670 rs3788338 chr22:23412058 G/A cg21100191 chr22:23484243 RTDR1 0.57 7.2 0.37 4.1e-12 Serum parathyroid hormone levels; LUSC cis rs13315871 0.929 rs9854438 chr3:58277327 G/A cg12435725 chr3:58293450 RPP14 -0.73 -7.51 -0.38 5.33e-13 Cholesterol, total; LUSC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg25427524 chr10:38739819 LOC399744 -0.68 -12.2 -0.56 1.43e-28 Extrinsic epigenetic age acceleration; LUSC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg19812747 chr11:111475976 SIK2 -0.54 -7.6 -0.38 2.97e-13 Primary sclerosing cholangitis; LUSC cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg18850127 chr7:39170497 POU6F2 0.64 9.64 0.47 1.41e-19 IgG glycosylation; LUSC cis rs3768617 0.510 rs10797849 chr1:183088988 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.0 0.52 3.3e-24 Fuchs's corneal dystrophy; LUSC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg18357526 chr6:26021779 HIST1H4A 0.38 6.07 0.32 3.39e-9 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg02569458 chr12:86230093 RASSF9 0.51 8.47 0.42 7.84e-16 Major depressive disorder; LUSC cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg08085267 chr17:45401833 C17orf57 -0.48 -7.6 -0.38 2.98e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7769051 0.708 rs9483514 chr6:133228716 G/A cg22852734 chr6:133119734 C6orf192 0.9 9.27 0.45 2.45e-18 Type 2 diabetes nephropathy; LUSC cis rs137603 0.644 rs94852 chr22:39712334 T/C cg17798944 chr22:39715225 SNORD43;RPL3 -0.5 -8.0 -0.4 2.02e-14 Primary biliary cholangitis; LUSC cis rs478304 0.654 rs1074156 chr11:65458169 G/T cg05805236 chr11:65401703 PCNXL3 -0.65 -10.68 -0.5 4.36e-23 Acne (severe); LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.77 -0.43 9.4e-17 Bipolar disorder; LUSC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg08975724 chr8:8085496 FLJ10661 0.55 8.43 0.42 1.03e-15 Systolic blood pressure; LUSC cis rs10504229 0.680 rs11777459 chr8:58044241 A/T cg21724239 chr8:58056113 NA 0.57 6.46 0.33 3.62e-10 Developmental language disorder (linguistic errors); LUSC cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg09184832 chr6:79620586 NA -0.44 -7.06 -0.36 9.88e-12 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.26 0.45 2.56e-18 Bipolar disorder; LUSC cis rs10979 1.000 rs9390104 chr6:143890978 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs7100689 0.646 rs1890889 chr10:82090827 G/T cg00277334 chr10:82204260 NA -0.57 -8.92 -0.44 3.14e-17 Post bronchodilator FEV1; LUSC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg16743903 chr16:89593216 SPG7 -0.37 -5.85 -0.31 1.15e-8 Multiple myeloma (IgH translocation); LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.82 -0.39 6.83e-14 Lymphocyte counts; LUSC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg02569458 chr12:86230093 RASSF9 0.48 7.63 0.39 2.49e-13 Major depressive disorder; LUSC cis rs11673344 0.504 rs1667378 chr19:37492073 C/A cg27390819 chr19:37464633 NA -0.35 -5.66 -0.3 3.3e-8 Obesity-related traits; LUSC cis rs6964587 0.839 rs62466159 chr7:91450507 A/G cg17063962 chr7:91808500 NA 0.56 8.54 0.42 4.84e-16 Breast cancer; LUSC cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg26528668 chr16:1614120 IFT140 0.43 7.06 0.36 9.54e-12 Coronary artery disease; LUSC cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.97 -0.36 1.73e-11 Blood metabolite levels; LUSC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.38 -0.33 5.76e-10 Neuroticism; LUSC cis rs9300255 0.544 rs1716157 chr12:123670473 T/C cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.48 -0.33 3.22e-10 Neutrophil percentage of white cells; LUSC cis rs1670533 1.000 rs6858612 chr4:1053353 C/T cg27284194 chr4:1044797 NA 0.59 9.01 0.44 1.64e-17 Recombination rate (females); LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg00149659 chr3:10157352 C3orf10 0.98 14.52 0.62 2.16e-37 Alzheimer's disease; LUSC trans rs17685 0.753 rs869804 chr7:75688954 A/G cg19862616 chr7:65841803 NCRNA00174 1.11 19.25 0.73 4.55e-56 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2439831 0.867 rs486301 chr15:43836949 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.75 7.56 0.38 3.86e-13 Lung cancer in ever smokers; LUSC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg21361702 chr7:150065534 REPIN1 0.51 6.53 0.34 2.5e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg06634786 chr22:41940651 POLR3H -0.55 -6.46 -0.33 3.75e-10 Vitiligo; LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg21782813 chr7:2030301 MAD1L1 0.41 6.79 0.35 5.2e-11 Bipolar disorder and schizophrenia; LUSC trans rs1005277 0.522 rs1208767 chr10:38042295 G/T cg17830980 chr10:43048298 ZNF37B -0.41 -6.38 -0.33 5.86e-10 Extrinsic epigenetic age acceleration; LUSC trans rs3733585 0.683 rs13112015 chr4:9933796 C/T cg26043149 chr18:55253948 FECH -0.45 -6.96 -0.36 1.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11229555 0.574 rs12272310 chr11:58186462 A/C cg15696309 chr11:58395628 NA -0.64 -7.78 -0.39 9.19e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs12421382 0.778 rs11213128 chr11:109489575 G/A cg27471124 chr11:109292789 C11orf87 0.43 7.42 0.38 9.62e-13 Schizophrenia; LUSC cis rs10779751 0.887 rs6686835 chr1:11305316 G/A cg08854313 chr1:11322531 MTOR 0.88 14.96 0.63 4.48e-39 Body mass index; LUSC cis rs8179 1.000 rs8179 chr7:92236164 T/C cg15732164 chr7:92237376 CDK6 0.54 7.25 0.37 2.97e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg22949040 chr2:204399512 RAPH1 0.5 6.65 0.34 1.19e-10 Neuroticism; LUSC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.81 -0.35 4.42e-11 Menopause (age at onset); LUSC cis rs1790761 0.967 rs869736 chr11:67205462 C/A cg24690094 chr11:67383802 NA -0.32 -5.84 -0.3 1.26e-8 Mean corpuscular volume; LUSC cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg15073853 chr19:18549131 ISYNA1 -0.32 -5.99 -0.31 5.32e-9 Breast cancer; LUSC cis rs763121 0.889 rs9607557 chr22:39040279 G/A cg06022373 chr22:39101656 GTPBP1 0.79 13.08 0.58 7.2e-32 Menopause (age at onset); LUSC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg04267008 chr7:1944627 MAD1L1 -0.54 -8.12 -0.41 9.4e-15 Bipolar disorder and schizophrenia; LUSC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg12560992 chr17:57184187 TRIM37 -0.89 -17.5 -0.69 3.97e-49 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18228282 chr17:46703908 HOXB9 -0.5 -5.97 -0.31 6.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg18252515 chr7:66147081 NA -1.19 -12.84 -0.57 5.85e-31 Diabetic kidney disease; LUSC cis rs17604090 0.878 rs10262227 chr7:29704073 G/A cg19413766 chr7:29689036 LOC646762 -0.64 -7.7 -0.39 1.56e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC trans rs7615952 0.609 rs13088451 chr3:125553499 G/C cg07211511 chr3:129823064 LOC729375 -1.04 -15.52 -0.65 2.79e-41 Blood pressure (smoking interaction); LUSC trans rs10511400 0.541 rs923727 chr3:119918124 G/A cg02809009 chr19:50354510 PTOV1 -0.68 -6.18 -0.32 1.82e-9 Economic and political preferences (feminism/equality); LUSC cis rs62400317 0.859 rs12201555 chr6:45294400 T/A cg18551225 chr6:44695536 NA -0.45 -7.46 -0.38 7.62e-13 Total body bone mineral density; LUSC cis rs7589342 0.628 rs11893695 chr2:106401300 C/G cg14210321 chr2:106509881 NCK2 0.46 5.83 0.3 1.3e-8 Addiction; LUSC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2204008 0.643 rs1315347 chr12:38162494 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.26 -0.49 1.18e-21 Bladder cancer; LUSC cis rs9644630 1.000 rs9644631 chr8:19370830 C/T cg01280390 chr8:19363452 CSGALNACT1 0.32 5.92 0.31 8.21e-9 Oropharynx cancer; LUSC cis rs62458065 0.513 rs9655340 chr7:32535920 A/G cg20159608 chr7:32802032 NA 0.71 9.34 0.46 1.36e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs1595825 0.627 rs76341431 chr2:198379118 G/A cg00982548 chr2:198649783 BOLL -0.52 -6.16 -0.32 2.13e-9 Ulcerative colitis; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg19723775 chr5:179050963 HNRNPH1 0.37 5.67 0.3 3.09e-8 Lung cancer; LUSC cis rs8072100 1.000 rs8065669 chr17:45724996 G/A cg25173405 chr17:45401733 C17orf57 -0.41 -6.52 -0.34 2.63e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs5758659 0.652 rs5758537 chr22:42397042 G/T cg04733989 chr22:42467013 NAGA 0.39 6.54 0.34 2.33e-10 Cognitive function; LUSC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.2 0.37 4.12e-12 Mean platelet volume; LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg00121533 chr1:75199117 CRYZ;TYW3 0.49 7.82 0.39 7e-14 Resistin levels; LUSC cis rs6918586 0.557 rs198827 chr6:26121002 C/T cg17691542 chr6:26056736 HIST1H1C 0.4 5.94 0.31 7.21e-9 Schizophrenia; LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18301423 chr5:131593218 PDLIM4 0.46 7.03 0.36 1.16e-11 Acylcarnitine levels; LUSC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg21770322 chr7:97807741 LMTK2 -0.55 -9.86 -0.47 2.79e-20 Breast cancer; LUSC cis rs2282300 0.702 rs4379811 chr11:30294760 C/T cg25418670 chr11:30344373 C11orf46 0.64 9.09 0.45 9.01e-18 Morning vs. evening chronotype; LUSC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg24642844 chr7:1081250 C7orf50 -0.69 -9.98 -0.48 1.06e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11785400 1.000 rs4266629 chr8:143736635 A/G cg24634471 chr8:143751801 JRK 0.59 8.98 0.44 1.97e-17 Schizophrenia; LUSC cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg23711669 chr6:146136114 FBXO30 -0.9 -17.81 -0.7 2.44e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs10465746 0.933 rs2224990 chr1:84436275 C/A cg10977910 chr1:84465055 TTLL7 0.41 6.05 0.31 3.81e-9 Obesity-related traits; LUSC cis rs2898681 0.581 rs730247 chr4:53680696 T/G cg00338735 chr4:53728038 RASL11B 0.43 5.81 0.3 1.46e-8 Optic nerve measurement (cup area); LUSC cis rs3540 0.574 rs8035980 chr15:90974390 C/G cg22089800 chr15:90895588 ZNF774 0.64 10.26 0.49 1.23e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs3125734 0.653 rs1007976 chr10:63970144 C/T cg19640130 chr10:64028056 RTKN2 0.39 7.01 0.36 1.34e-11 Rheumatoid arthritis; LUSC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg18479299 chr3:125709523 NA -0.48 -5.89 -0.31 9.37e-9 Blood pressure (smoking interaction); LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg04025307 chr7:1156635 C7orf50 0.41 6.31 0.33 8.73e-10 Longevity;Endometriosis; LUSC cis rs9329221 0.662 rs13254942 chr8:10257678 C/T cg21775007 chr8:11205619 TDH -0.44 -6.06 -0.31 3.58e-9 Neuroticism; LUSC cis rs12458462 0.812 rs34583578 chr18:77491070 C/T cg11879182 chr18:77439856 CTDP1 0.7 10.42 0.5 3.47e-22 Monocyte count; LUSC trans rs3942852 0.806 rs1503188 chr11:48117478 C/T cg03929089 chr4:120376271 NA -0.55 -6.77 -0.35 5.75e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs6456156 0.586 rs7746628 chr6:167483235 A/G cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg12219531 chr12:120966889 COQ5 0.59 7.71 0.39 1.41e-13 High light scatter reticulocyte count; LUSC cis rs13315871 0.929 rs11130628 chr3:58315835 T/C cg12435725 chr3:58293450 RPP14 -0.69 -7.02 -0.36 1.21e-11 Cholesterol, total; LUSC cis rs10208940 0.920 rs11893513 chr2:68760647 C/T cg12452813 chr2:68675892 NA 0.57 5.95 0.31 6.95e-9 Urate levels in lean individuals; LUSC cis rs7429990 0.965 rs1550914 chr3:47995168 A/C cg11946769 chr3:48343235 NME6 0.48 6.6 0.34 1.59e-10 Educational attainment (years of education); LUSC cis rs7107174 0.892 rs1567891 chr11:78101985 A/G cg02023728 chr11:77925099 USP35 0.46 6.7 0.34 8.82e-11 Testicular germ cell tumor; LUSC cis rs9646954 0.560 rs4149507 chr2:101032745 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.77 -0.43 9.38e-17 Intelligence (multi-trait analysis); LUSC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg00012203 chr2:219082015 ARPC2 -0.69 -11.35 -0.53 1.78e-25 Colorectal cancer; LUSC trans rs12579753 0.810 rs10862355 chr12:82162698 C/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.86 -0.35 3.39e-11 Resting heart rate; LUSC cis rs9796 0.621 rs1659228 chr15:41471978 A/G cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.53 -0.42 5.24e-16 Menopause (age at onset); LUSC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg05896524 chr21:47604654 C21orf56 0.47 6.92 0.35 2.31e-11 Testicular germ cell tumor; LUSC cis rs9487051 0.768 rs351742 chr6:109527325 C/T cg00509249 chr6:109615579 CCDC162 0.34 5.87 0.31 1.05e-8 Reticulocyte fraction of red cells; LUSC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg15485101 chr11:133734466 NA 0.42 7.65 0.39 2.13e-13 Childhood ear infection; LUSC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg20243544 chr17:37824526 PNMT 0.5 6.95 0.36 1.96e-11 Asthma; LUSC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg17971929 chr21:40555470 PSMG1 0.8 13.95 0.61 3.66e-35 Cognitive function; LUSC trans rs61931739 0.500 rs11053277 chr12:34553835 T/A cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs11676348 0.772 rs11676275 chr2:218944808 G/A cg00012203 chr2:219082015 ARPC2 -0.48 -7.37 -0.37 1.34e-12 Ulcerative colitis; LUSC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg22907277 chr7:1156413 C7orf50 0.57 6.31 0.33 9.01e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.26 -0.41 3.33e-15 Body mass index; LUSC cis rs7647973 1.000 rs1009051 chr3:49521549 G/A cg07636037 chr3:49044803 WDR6 0.7 9.29 0.45 2.11e-18 Menarche (age at onset); LUSC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg06634786 chr22:41940651 POLR3H -0.49 -5.75 -0.3 2e-8 Vitiligo; LUSC trans rs208520 0.661 rs207111 chr6:66792513 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC cis rs25645 0.502 rs7209742 chr17:38108708 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -9.19 -0.45 4.25e-18 Myeloid white cell count; LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.57 10.02 0.48 7.68e-21 Bipolar disorder; LUSC trans rs7980799 0.935 rs4931717 chr12:33521151 A/G cg26384229 chr12:38710491 ALG10B 0.43 6.12 0.32 2.65e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg25174290 chr11:3078921 CARS 0.59 9.17 0.45 4.93e-18 Longevity; LUSC cis rs11758351 1.000 rs16891378 chr6:26188864 A/G cg23601095 chr6:26197514 HIST1H3D 0.66 7.06 0.36 9.54e-12 Gout;Renal underexcretion gout; LUSC cis rs9814567 0.752 rs9848254 chr3:134330374 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22819488 chr3:28390286 AZI2 -0.51 -6.6 -0.34 1.63e-10 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg09699651 chr6:150184138 LRP11 0.37 5.76 0.3 1.92e-8 Lung cancer; LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg10295955 chr4:187884368 NA -0.98 -18.12 -0.7 1.34e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs16937 0.521 rs78176224 chr1:205178609 G/A cg00857998 chr1:205179979 DSTYK 0.47 6.66 0.34 1.1e-10 Schizophrenia; LUSC cis rs10072221 0.836 rs7731240 chr5:75707576 T/C cg03132911 chr5:75698732 IQGAP2 0.36 6.07 0.32 3.46e-9 Mean platelet volume; LUSC trans rs1422110 0.513 rs987280 chr5:85448604 C/T cg01787110 chr1:109008453 NBPF6 -0.43 -7.86 -0.4 5.47e-14 Attention function in attention deficit hyperactive disorder; LUSC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg07701084 chr6:150067640 NUP43 0.53 8.01 0.4 1.97e-14 Lung cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01727434 chr2:152118530 RBM43 0.46 6.54 0.34 2.29e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3862260 1.000 rs3862260 chr1:120160789 G/A cg16322792 chr1:120165303 ZNF697 0.5 9.59 0.46 2.2e-19 Systemic lupus erythematosus; LUSC cis rs16976116 0.901 rs28541469 chr15:55500788 G/A cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs865483 0.895 rs4795203 chr17:35828972 T/C cg06716730 chr17:35851459 DUSP14 0.28 6.18 0.32 1.91e-9 Monocyte count; LUSC trans rs634534 0.622 rs1308733 chr11:65720841 T/C cg17712092 chr4:129076599 LARP1B -0.76 -11.19 -0.52 6.99e-25 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.54 0.57 8.02e-30 Motion sickness; LUSC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.84 -0.39 6.1e-14 Blood metabolite levels; LUSC cis rs2652834 0.808 rs4775614 chr15:63351687 A/G cg05507819 chr15:63340323 TPM1 0.69 8.66 0.43 2.05e-16 HDL cholesterol; LUSC cis rs11098499 0.738 rs28687057 chr4:120280812 A/G cg24375607 chr4:120327624 NA 0.69 10.58 0.5 9.19e-23 Corneal astigmatism; LUSC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg07936489 chr17:37558343 FBXL20 -0.71 -10.02 -0.48 7.57e-21 Glomerular filtration rate (creatinine); LUSC cis rs1403694 0.515 rs1656925 chr3:186449123 T/C cg12454167 chr3:186435060 KNG1 0.28 7.6 0.38 2.98e-13 Blood protein levels; LUSC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg15448220 chr1:150897856 SETDB1 0.4 5.89 0.31 9.28e-9 Melanoma; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg20887711 chr4:1340912 KIAA1530 0.4 5.98 0.31 5.86e-9 Obesity-related traits; LUSC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg05872129 chr22:39784769 NA -0.58 -10.59 -0.5 8.65e-23 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02018176 chr4:1364513 KIAA1530 -0.68 -12.62 -0.57 3.9e-30 Longevity; LUSC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs3741151 1.000 rs76887714 chr11:73045500 C/T cg17517138 chr11:73019481 ARHGEF17 0.97 8.93 0.44 2.96e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs17092148 0.945 rs6060034 chr20:33351864 T/C cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg25732426 chr21:46294058 PTTG1IP -0.48 -6.48 -0.33 3.28e-10 Cognitive function;Information processing speed; LUSC cis rs2932538 0.922 rs6663922 chr1:113095948 T/C cg22162597 chr1:113214053 CAPZA1 0.55 7.89 0.4 4.48e-14 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs4808199 1.000 rs60321073 chr19:19499598 A/G cg03709012 chr19:19516395 GATAD2A 1.14 14.77 0.63 2.43e-38 Nonalcoholic fatty liver disease; LUSC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs920590 0.684 rs57837509 chr8:19670088 A/G cg03894339 chr8:19674705 INTS10 0.56 7.6 0.38 2.96e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs3741151 0.686 rs12285885 chr11:73294478 A/G cg17517138 chr11:73019481 ARHGEF17 0.86 8.29 0.41 2.84e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7827545 1.000 rs2119879 chr8:135549042 T/C cg17885191 chr8:135476712 NA 0.56 8.2 0.41 5.4e-15 Hypertension (SNP x SNP interaction); LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg10253484 chr15:75165896 SCAMP2 -0.41 -5.84 -0.3 1.27e-8 Breast cancer; LUSC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg16524733 chr11:117070046 TAGLN -0.44 -7.73 -0.39 1.3e-13 Blood protein levels; LUSC cis rs9611565 0.694 rs5758389 chr22:41941749 T/C cg03806693 chr22:41940476 POLR3H -0.86 -12.16 -0.55 2.1e-28 Vitiligo; LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg06873352 chr17:61820015 STRADA 0.69 12.57 0.57 6.08e-30 Prudent dietary pattern; LUSC cis rs6545883 0.540 rs11687956 chr2:61851342 T/C cg15711740 chr2:61764176 XPO1 0.36 5.69 0.3 2.74e-8 Tuberculosis; LUSC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg01416388 chr22:39784598 NA -0.44 -7.34 -0.37 1.65e-12 Intelligence (multi-trait analysis); LUSC cis rs11630290 0.589 rs1396711 chr15:64168368 G/A cg12036633 chr15:63758958 NA 0.48 6.03 0.31 4.41e-9 Iris characteristics; LUSC cis rs9788682 0.747 rs8042494 chr15:78908010 C/T cg06917634 chr15:78832804 PSMA4 -0.52 -6.71 -0.34 8.12e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7267979 0.668 rs4815398 chr20:25237338 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.63 -11.17 -0.52 8.01e-25 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2760061 0.583 rs1745413 chr1:228212456 A/G cg02753203 chr1:228287806 NA 1.0 19.97 0.74 6.03e-59 Diastolic blood pressure; LUSC cis rs9902453 0.868 rs12944395 chr17:28323499 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -10.29 -0.49 9.22e-22 Coffee consumption (cups per day); LUSC cis rs13385 0.769 rs6878006 chr5:139595751 T/C cg26211634 chr5:139558579 C5orf32 0.45 6.73 0.35 7.44e-11 Atrial fibrillation; LUSC cis rs1003719 0.788 rs2835586 chr21:38461326 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.29 0.53 3.03e-25 Eye color traits; LUSC cis rs11785400 0.793 rs4736366 chr8:143742413 C/T cg10596483 chr8:143751796 JRK 0.56 7.97 0.4 2.55e-14 Schizophrenia; LUSC cis rs12210905 0.925 rs11961181 chr6:26994163 C/G cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.95 -0.31 6.94e-9 Hip circumference adjusted for BMI; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09015484 chr9:96929106 NA 0.45 7.06 0.36 9.53e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2742417 0.967 rs6800556 chr3:45752229 G/T cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2985684 1.000 rs2985697 chr14:50092902 A/G cg04989706 chr14:50066350 PPIL5 -0.43 -5.68 -0.3 2.87e-8 Carotid intima media thickness; LUSC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg26380479 chr7:97908229 NA -0.28 -6.26 -0.32 1.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7937682 0.855 rs11213985 chr11:111581521 C/A cg19812747 chr11:111475976 SIK2 -0.48 -6.92 -0.35 2.33e-11 Primary sclerosing cholangitis; LUSC cis rs11098499 0.754 rs938056 chr4:120237453 C/T cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.27e-28 Corneal astigmatism; LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.25 0.32 1.25e-9 Platelet count; LUSC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg04369109 chr6:150039330 LATS1 -0.58 -8.45 -0.42 9.34e-16 Lung cancer; LUSC cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.75 0.3 1.98e-8 Personality dimensions; LUSC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg06238570 chr21:40685208 BRWD1 0.49 7.63 0.39 2.56e-13 Cognitive function; LUSC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg18512352 chr11:47633146 NA -0.46 -9.21 -0.45 3.73e-18 Subjective well-being; LUSC cis rs11098499 0.909 rs7681214 chr4:120385320 C/A cg09307838 chr4:120376055 NA 0.78 11.26 0.52 3.88e-25 Corneal astigmatism; LUSC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11890956 chr21:40555474 PSMG1 1.05 21.0 0.75 5.11e-63 Cognitive function; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg06675538 chr2:114033490 PAX8;LOC440839 -0.31 -5.65 -0.3 3.46e-8 Lymphocyte counts; LUSC cis rs11166629 1.000 rs966659 chr8:135639045 C/T cg21672855 chr8:135614777 ZFAT -0.37 -5.98 -0.31 5.65e-9 Smoking quantity; LUSC cis rs9287719 0.967 rs4669596 chr2:10720572 C/T cg03983476 chr2:10830698 NOL10 -0.37 -5.66 -0.3 3.31e-8 Prostate cancer; LUSC cis rs66887589 0.616 rs6822808 chr4:120217365 C/A cg24375607 chr4:120327624 NA 0.49 7.34 0.37 1.65e-12 Diastolic blood pressure; LUSC cis rs9300255 0.602 rs1727316 chr12:123618603 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.02 -0.31 4.56e-9 Neutrophil percentage of white cells; LUSC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg03605463 chr16:89740564 NA 0.6 9.48 0.46 4.9e-19 Vitiligo; LUSC cis rs7843479 1.000 rs2306641 chr8:21833965 A/G cg17168535 chr8:21777572 XPO7 -0.66 -10.23 -0.49 1.56e-21 Mean corpuscular volume; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg26396475 chr15:41186434 VPS18 -0.48 -6.13 -0.32 2.49e-9 Neuroticism; LUSC cis rs11190604 1.000 rs11190604 chr10:102302457 A/G cg16342193 chr10:102329863 NA -0.34 -6.03 -0.31 4.35e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg25036284 chr2:26402008 FAM59B -0.69 -9.6 -0.46 1.99e-19 Gut microbiome composition (summer); LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg00431813 chr7:1051703 C7orf50 -0.46 -7.55 -0.38 4.26e-13 Longevity;Endometriosis; LUSC trans rs10771431 0.967 rs7137443 chr12:9372029 C/T cg27600084 chr12:12264075 NA 0.45 6.64 0.34 1.26e-10 Breast size; LUSC cis rs8017423 0.967 rs8009493 chr14:90690083 G/C cg14092571 chr14:90743983 NA -0.36 -5.92 -0.31 8.1e-9 Mortality in heart failure; LUSC cis rs3617 0.539 rs9825369 chr3:52953311 T/C cg18099408 chr3:52552593 STAB1 0.35 5.9 0.31 8.87e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1551570 0.755 rs11667630 chr19:10229297 A/C cg16327482 chr19:10226339 EIF3G -0.39 -7.32 -0.37 1.82e-12 Narcolepsy; LUSC cis rs7072216 0.763 rs7909822 chr10:100172035 A/C cg26618903 chr10:100175079 PYROXD2 -0.45 -8.49 -0.42 7.03e-16 Metabolite levels; LUSC trans rs2587949 0.615 rs2587950 chr3:4225251 A/G cg15139668 chr4:4577005 NA -0.42 -6.18 -0.32 1.91e-9 Periodontitis (DPAL); LUSC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg11752832 chr7:134001865 SLC35B4 0.56 8.71 0.43 1.41e-16 Mean platelet volume; LUSC cis rs8060686 0.668 rs255056 chr16:68016185 G/C cg09835421 chr16:68378352 PRMT7 -0.54 -6.22 -0.32 1.5e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -7.46 -0.38 7.48e-13 Menarche (age at onset); LUSC cis rs3099143 1.000 rs3110378 chr15:77127983 G/A cg21673338 chr15:77095150 SCAPER -0.81 -7.62 -0.38 2.59e-13 Recalcitrant atopic dermatitis; LUSC trans rs12458462 0.859 rs34242155 chr18:77425192 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.49 -6.92 -0.35 2.29e-11 Monocyte count; LUSC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg04450456 chr4:17643702 FAM184B 0.43 7.21 0.37 3.8e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg04166393 chr7:2884313 GNA12 0.41 5.68 0.3 2.93e-8 Height; LUSC cis rs4242434 0.597 rs876714 chr8:22482799 A/G cg03733263 chr8:22462867 KIAA1967 0.76 12.36 0.56 3.61e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs9549367 0.662 rs3818334 chr13:113825174 C/G cg00898013 chr13:113819073 PROZ -0.64 -9.1 -0.45 8.6e-18 Platelet distribution width; LUSC cis rs4595586 0.545 rs11615638 chr12:39364766 A/C cg13010199 chr12:38710504 ALG10B 0.42 6.1 0.32 2.93e-9 Morning vs. evening chronotype; LUSC cis rs6964587 1.000 rs55745934 chr7:91670998 T/C cg17063962 chr7:91808500 NA 0.57 8.74 0.43 1.12e-16 Breast cancer; LUSC trans rs1864585 0.520 rs12155811 chr8:10673513 C/T cg26278703 chr11:58910052 FAM111A 0.54 6.01 0.31 4.92e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg01097406 chr16:89675127 NA -0.33 -6.45 -0.33 3.94e-10 Vitiligo; LUSC cis rs12928939 0.774 rs7205340 chr16:71645670 A/T cg03805757 chr16:71968109 PKD1L3 0.39 5.73 0.3 2.2e-8 Post bronchodilator FEV1; LUSC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg03233332 chr7:66118400 NA 0.41 6.05 0.31 3.95e-9 Aortic root size; LUSC cis rs12545109 0.643 rs1119707 chr8:57411548 T/C cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.11e-10 Obesity-related traits; LUSC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC trans rs4839604 0.568 rs62279673 chr3:142947027 A/C cg27067618 chr19:15751949 CYP4F3 0.36 6.0 0.31 5.19e-9 N-glycan levels; LUSC cis rs6121246 0.567 rs6087701 chr20:30217708 A/C cg18721089 chr20:30220636 NA -0.39 -6.12 -0.32 2.66e-9 Mean corpuscular hemoglobin; LUSC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg11657440 chr19:46296263 DMWD 0.87 16.47 0.67 4.98e-45 Coronary artery disease; LUSC cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg06784218 chr1:46089804 CCDC17 -0.47 -8.88 -0.44 4.2e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11098499 0.691 rs17009144 chr4:120270795 C/T cg24375607 chr4:120327624 NA -0.67 -10.87 -0.51 9.07e-24 Corneal astigmatism; LUSC cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg00049323 chr5:472564 LOC25845 0.49 7.77 0.39 1.01e-13 Cystic fibrosis severity; LUSC cis rs7267979 1.000 rs2258884 chr20:25279539 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2932538 0.922 rs6673930 chr1:113104887 A/G cg22162597 chr1:113214053 CAPZA1 0.7 10.0 0.48 9.16e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs2979489 0.945 rs11993146 chr8:30319537 G/A cg26383811 chr8:30366931 RBPMS -0.49 -7.8 -0.39 7.78e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg24642844 chr7:1081250 C7orf50 -0.46 -7.34 -0.37 1.64e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg19901468 chr14:105411992 AHNAK2 -0.71 -12.32 -0.56 5.23e-29 Rheumatoid arthritis; LUSC cis rs1577917 0.958 rs12208227 chr6:86670944 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.17 -0.41 6.28e-15 Response to antipsychotic treatment; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17832277 chr13:103249000 TPP2 0.47 6.68 0.34 9.77e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.54 7.94 0.4 3.03e-14 Gut microbiome composition (summer); LUSC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg13877915 chr19:58951672 ZNF132 0.5 7.97 0.4 2.57e-14 Uric acid clearance; LUSC cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg24558204 chr6:135376177 HBS1L 0.68 10.64 0.5 6.01e-23 High light scatter reticulocyte percentage of red cells; LUSC cis rs2227930 0.506 rs13087972 chr3:142047637 G/T cg16271453 chr3:142027066 XRN1 -0.55 -9.96 -0.48 1.27e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs2200578 1.000 rs7566277 chr2:99916242 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.31 0.33 9.03e-10 IgG glycosylation; LUSC cis rs12681287 0.517 rs68008113 chr8:87520894 C/A cg00550725 chr8:87521180 FAM82B 0.44 5.75 0.3 1.99e-8 Caudate activity during reward; LUSC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg03517284 chr6:25882590 NA 0.63 11.01 0.52 2.81e-24 Blood metabolite levels; LUSC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg03806693 chr22:41940476 POLR3H 1.0 13.8 0.6 1.32e-34 Vitiligo; LUSC cis rs4319547 0.656 rs7135419 chr12:122911861 T/A cg23029597 chr12:123009494 RSRC2 -0.73 -9.05 -0.44 1.21e-17 Body mass index; LUSC cis rs921968 0.541 rs6717433 chr2:219375711 G/C cg02176678 chr2:219576539 TTLL4 -0.74 -13.97 -0.61 3.16e-35 Mean corpuscular hemoglobin concentration; LUSC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.27 0.37 2.51e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs3087591 0.920 rs7225014 chr17:29572973 A/G cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.91 -0.4 3.72e-14 Hip circumference; LUSC cis rs11048434 0.736 rs12812913 chr12:9110836 C/G cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC cis rs765787 0.530 rs12904265 chr15:45526713 C/T cg24006582 chr15:45444508 DUOX1 0.67 9.61 0.47 1.77e-19 Uric acid levels; LUSC cis rs372883 0.580 rs2254038 chr21:30745722 C/T cg24692254 chr21:30365293 RNF160 0.68 10.46 0.5 2.49e-22 Pancreatic cancer; LUSC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg23281280 chr6:28129359 ZNF389 0.44 5.82 0.3 1.36e-8 Parkinson's disease; LUSC cis rs9814567 1.000 rs3846056 chr3:134227292 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.74 -0.6 2.34e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.51 -6.93 -0.35 2.14e-11 Tuberculosis; LUSC cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg13010199 chr12:38710504 ALG10B 0.65 10.04 0.48 6.91e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg06740227 chr12:86229804 RASSF9 0.39 6.23 0.32 1.44e-9 Major depressive disorder; LUSC cis rs6977660 0.714 rs6976972 chr7:19818315 C/A cg07541023 chr7:19748670 TWISTNB 0.6 6.51 0.34 2.7e-10 Thyroid stimulating hormone; LUSC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg06618935 chr21:46677482 NA -0.39 -8.03 -0.4 1.63e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg07677032 chr17:61819896 STRADA 0.55 9.09 0.45 9.21e-18 Prudent dietary pattern; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg06600287 chr1:53387719 ECHDC2 0.31 6.18 0.32 1.85e-9 Monocyte count; LUSC cis rs16912285 0.591 rs12794505 chr11:24364195 A/G ch.11.24196551F chr11:24239977 NA -0.8 -8.86 -0.44 4.72e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs950027 0.620 rs1145077 chr15:45683795 A/C cg21132104 chr15:45694354 SPATA5L1 -0.4 -6.0 -0.31 5.21e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.08 -16.89 -0.68 1.03e-46 Gut microbiome composition (summer); LUSC cis rs7189233 0.955 rs7189726 chr16:53497774 C/T cg09728985 chr16:53543985 NA -0.34 -6.13 -0.32 2.5e-9 Intelligence (multi-trait analysis); LUSC cis rs9929218 0.906 rs9932679 chr16:68751904 A/G cg02972257 chr16:68554789 NA 0.46 6.02 0.31 4.5e-9 Colorectal cancer; LUSC cis rs55794721 0.509 rs12027135 chr1:25775733 A/T cg02931644 chr1:25747376 RHCE 0.34 6.11 0.32 2.77e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs9814567 0.896 rs6763188 chr3:134349995 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.86 14.36 0.62 9.18e-37 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg21782813 chr7:2030301 MAD1L1 0.49 8.28 0.41 2.94e-15 Bipolar disorder and schizophrenia; LUSC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg19729930 chr2:74357872 NA 0.94 18.09 0.7 1.76e-51 Gestational age at birth (maternal effect); LUSC cis rs8028313 0.609 rs28735117 chr15:67933892 C/T cg27219399 chr15:67835830 MAP2K5 0.37 5.93 0.31 7.37e-9 Obesity; LUSC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC trans rs11098499 1.000 rs13435802 chr4:120177960 A/T cg19731845 chr4:166199412 KLHL2;GK3P -0.46 -6.4 -0.33 5.11e-10 Corneal astigmatism; LUSC cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.17e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg08470875 chr2:26401718 FAM59B -0.66 -8.86 -0.44 4.75e-17 Gut microbiome composition (summer); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg15604682 chr7:102105781 ALKBH4;LRWD1 -0.35 -5.98 -0.31 5.74e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4363385 0.510 rs6689066 chr1:153045154 T/C cg25856811 chr1:152973957 SPRR3 -0.37 -6.11 -0.32 2.78e-9 Inflammatory skin disease; LUSC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.76 -0.47 5.78e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg01256987 chr12:42539512 GXYLT1 -0.45 -8.57 -0.42 3.86e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg21535247 chr6:8435926 SLC35B3 0.59 9.06 0.44 1.09e-17 Motion sickness; LUSC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg05425664 chr17:57184151 TRIM37 -0.56 -8.29 -0.41 2.82e-15 Intelligence (multi-trait analysis); LUSC cis rs2795502 1.000 rs2796575 chr10:43374911 A/G cg27426351 chr10:43362370 NA 0.43 5.76 0.3 1.94e-8 Blood protein levels; LUSC cis rs7568458 0.846 rs2028900 chr2:85767735 A/G cg17127132 chr2:85788382 GGCX -0.47 -7.5 -0.38 5.68e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs926392 0.533 rs6129162 chr20:37683195 G/A cg16355469 chr20:37678765 NA 0.53 7.04 0.36 1.08e-11 Dialysis-related mortality; LUSC cis rs754466 0.874 rs55910200 chr10:79665173 T/C cg17075019 chr10:79541650 NA -0.64 -8.35 -0.42 1.84e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1008375 1.000 rs7671752 chr4:17661398 C/T cg15017067 chr4:17643749 FAM184B 0.35 5.7 0.3 2.58e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2742234 0.955 rs1272142 chr10:43695484 G/T cg02780029 chr10:43622663 RET -0.34 -6.44 -0.33 4.07e-10 Hirschsprung disease; LUSC cis rs62244186 0.541 rs3804583 chr3:44884647 G/T cg16615211 chr3:44902933 MIR564;TMEM42 0.37 6.52 0.34 2.57e-10 Depressive symptoms; LUSC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg03929089 chr4:120376271 NA -1.04 -20.24 -0.74 5.37e-60 Height; LUSC cis rs4243830 0.850 rs932112 chr1:6591937 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -10.62 -0.5 6.96e-23 Body mass index; LUSC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.78 0.6 1.66e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs35264875 0.808 rs921675 chr11:68869034 A/G cg02660097 chr11:68866761 NA -0.37 -5.94 -0.31 7.11e-9 Blond vs. brown hair color; LUSC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.41 0.53 1.14e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9677476 0.863 rs2006780 chr2:232066704 T/G cg07929768 chr2:232055508 NA 0.36 6.92 0.35 2.36e-11 Food antigen IgG levels; LUSC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.46 -0.38 7.54e-13 Height; LUSC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg08847533 chr14:75593920 NEK9 -0.79 -13.38 -0.59 5.35e-33 Height; LUSC cis rs9814567 1.000 rs7645295 chr3:134307734 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.54 -0.6 1.34e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg18512352 chr11:47633146 NA -0.46 -9.27 -0.45 2.36e-18 Subjective well-being; LUSC cis rs6430585 0.591 rs3098103 chr2:136656094 T/C cg07169764 chr2:136633963 MCM6 1.13 17.36 0.69 1.42e-48 Corneal structure; LUSC cis rs78456975 1.000 rs11883965 chr2:1560062 T/C cg12573674 chr2:1569213 NA -0.54 -5.98 -0.31 5.59e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs977987 0.778 rs35214308 chr16:75476088 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.16 -0.36 5.2e-12 Dupuytren's disease; LUSC cis rs67460515 0.859 rs7610800 chr3:161002582 C/T cg03342759 chr3:160939853 NMD3 -0.53 -7.88 -0.4 4.69e-14 Parkinson's disease; LUSC cis rs688020 1.000 rs673500 chr7:4229445 C/G cg02004499 chr7:4244250 SDK1 -0.48 -7.75 -0.39 1.12e-13 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg26752657 chr1:75199075 CRYZ;TYW3 0.4 6.14 0.32 2.41e-9 Resistin levels; LUSC cis rs7923609 0.776 rs10761785 chr10:65318766 G/T cg01631684 chr10:65280961 REEP3 -0.4 -5.88 -0.31 9.82e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9311676 0.656 rs11917567 chr3:58382254 C/T cg26110898 chr3:58419937 PDHB 0.4 6.45 0.33 4.01e-10 Systemic lupus erythematosus; LUSC cis rs7267979 0.966 rs2261720 chr20:25260641 T/G cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.18e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6942756 0.806 rs2718093 chr7:128939582 G/A cg02491457 chr7:128862824 NA -0.48 -7.33 -0.37 1.69e-12 White matter hyperintensity burden; LUSC cis rs11112613 0.713 rs871220 chr12:105938558 G/A cg03607813 chr12:105948248 NA 0.78 11.55 0.53 3.48e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7091068 0.671 rs517785 chr10:95403973 G/A cg20715218 chr10:95462985 C10orf4 -0.59 -6.78 -0.35 5.32e-11 Urinary tract infection frequency; LUSC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg11812906 chr14:75593930 NEK9 -0.65 -11.1 -0.52 1.41e-24 Height; LUSC cis rs7267979 1.000 rs2258617 chr20:25274318 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg05347473 chr6:146136440 FBXO30 0.54 9.24 0.45 3.03e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03130627 chr6:159240554 EZR -0.44 -6.65 -0.34 1.17e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7113850 0.541 rs78363992 chr11:24232126 C/T ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Bone fracture in osteoporosis; LUSC trans rs62103177 0.759 rs9956512 chr18:77607517 G/A cg14227996 chr4:17616232 MED28 0.79 8.14 0.41 7.78e-15 Opioid sensitivity; LUSC cis rs2274273 0.624 rs1972221 chr14:55785381 C/A cg04306507 chr14:55594613 LGALS3 0.48 9.7 0.47 9.23e-20 Protein biomarker; LUSC cis rs6582630 0.533 rs11504406 chr12:38334580 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.3 -0.33 9.46e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg13939156 chr17:80058883 NA -0.34 -6.64 -0.34 1.28e-10 Life satisfaction; LUSC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -7.07 -0.36 9.25e-12 Lung cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18147735 chr4:39460314 LIAS;RPL9 0.45 6.83 0.35 4.08e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg25208724 chr1:156163844 SLC25A44 1.09 26.46 0.82 5.76e-84 Testicular germ cell tumor; LUSC cis rs3020736 0.500 rs1801311 chr22:42486723 G/A cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs9910292 0.591 rs6505325 chr17:31354124 C/T cg03789507 chr8:136667083 NA 0.48 6.13 0.32 2.44e-9 Mosquito bite size; LUSC cis rs11098499 0.954 rs7687843 chr4:120421211 C/T cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.06 0.36 9.49e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs62103177 0.759 rs9956512 chr18:77607517 G/A cg05926928 chr17:57297772 GDPD1 1.49 19.18 0.72 8.55e-56 Opioid sensitivity; LUSC cis rs9815354 0.812 rs17284313 chr3:41986787 G/T cg03022575 chr3:42003672 ULK4 -0.83 -8.85 -0.44 5.12e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs7267979 1.000 rs11087521 chr20:25440648 G/A cg08601574 chr20:25228251 PYGB 0.42 6.29 0.33 9.95e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.43 5.7 0.3 2.68e-8 Cognitive ability; LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg03209541 chr12:89919758 WDR51B;GALNT4 0.4 5.97 0.31 6.09e-9 Bladder cancer; LUSC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg15448220 chr1:150897856 SETDB1 0.41 5.96 0.31 6.27e-9 Melanoma; LUSC cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg27446573 chr6:127587934 RNF146 0.92 15.35 0.64 1.35e-40 Breast cancer; LUSC cis rs4704187 0.617 rs7356697 chr5:74354542 A/G cg03227963 chr5:74354835 NA 0.32 6.94 0.36 2.03e-11 Response to amphetamines; LUSC cis rs9650315 0.810 rs34747243 chr8:57202187 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.31 0.37 1.93e-12 Height; LUSC cis rs950027 0.620 rs35861938 chr15:45637343 T/C cg04036182 chr15:45458818 NA 0.34 5.74 0.3 2.13e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg06212747 chr3:49208901 KLHDC8B 0.48 6.13 0.32 2.54e-9 Parkinson's disease; LUSC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg16386425 chr10:429943 DIP2C -0.37 -5.76 -0.3 1.87e-8 Psychosis in Alzheimer's disease; LUSC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg11344533 chr11:111475393 SIK2 -0.49 -6.79 -0.35 5.28e-11 Primary sclerosing cholangitis; LUSC cis rs6088813 0.961 rs745931 chr20:33956004 A/T cg14752227 chr20:34000481 UQCC -0.36 -5.66 -0.3 3.25e-8 Height; LUSC cis rs7605827 0.930 rs2380653 chr2:15635011 C/A cg19274914 chr2:15703543 NA 0.46 8.77 0.43 9.47e-17 Educational attainment (years of education); LUSC cis rs6087771 0.642 rs6060411 chr20:30222139 T/C cg18721089 chr20:30220636 NA -0.34 -5.82 -0.3 1.35e-8 Subcortical brain region volumes;Putamen volume; LUSC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg03929089 chr4:120376271 NA 0.94 15.1 0.64 1.29e-39 Coronary artery disease; LUSC cis rs2573652 0.698 rs12916269 chr15:100530216 A/T cg00587665 chr15:100533223 ADAMTS17 0.45 8.14 0.41 7.89e-15 Height; LUSC cis rs7809950 1.000 rs4727684 chr7:107226470 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.81 -0.43 7.11e-17 Coronary artery disease; LUSC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg27165867 chr14:105738592 BRF1 -0.51 -7.45 -0.38 8.03e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg02807482 chr3:125708958 NA -0.54 -6.74 -0.35 6.88e-11 Blood pressure (smoking interaction); LUSC trans rs11662586 0.517 rs11663082 chr18:77713494 C/T cg05926928 chr17:57297772 GDPD1 0.6 9.25 0.45 2.77e-18 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs2073300 1.000 rs6137975 chr20:23461778 A/G cg09953122 chr20:23471693 CST8 0.72 6.96 0.36 1.86e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10791097 0.592 rs4936122 chr11:130734264 A/C cg12179176 chr11:130786555 SNX19 0.81 13.98 0.61 2.69e-35 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4285028 0.747 rs4048703 chr3:121374361 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.92 -12.8 -0.57 8.41e-31 Multiple sclerosis; LUSC cis rs7119 0.717 rs12901471 chr15:77818992 A/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.48 -0.33 3.24e-10 Type 2 diabetes; LUSC cis rs738322 0.775 rs13056506 chr22:38580917 G/T cg25457927 chr22:38595422 NA 0.48 10.26 0.49 1.18e-21 Cutaneous nevi; LUSC cis rs9747201 1.000 rs56283054 chr17:80135326 C/T cg17462356 chr17:80056334 FASN 0.43 5.9 0.31 8.77e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12421382 0.659 rs60143378 chr11:109385513 T/C cg11473876 chr11:109292803 C11orf87 0.41 6.73 0.35 7.35e-11 Schizophrenia; LUSC trans rs2727020 0.595 rs11040416 chr11:49566429 C/T cg03929089 chr4:120376271 NA -0.99 -17.7 -0.7 6.18e-50 Coronary artery disease; LUSC cis rs9549260 0.755 rs3900833 chr13:41188292 A/G cg21288729 chr13:41239152 FOXO1 0.6 9.05 0.44 1.17e-17 Red blood cell count; LUSC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg18240062 chr17:79603768 NPLOC4 -0.59 -10.11 -0.48 3.92e-21 Eye color traits; LUSC cis rs9479482 1.000 rs9479405 chr6:150338065 G/A cg07578070 chr6:150326732 RAET1K 0.41 6.37 0.33 6.21e-10 Alopecia areata; LUSC cis rs2976388 1.000 rs2920297 chr8:143763083 A/G cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs662064 0.962 rs596537 chr1:10554709 G/T cg20482658 chr1:10539492 PEX14 -0.32 -6.66 -0.34 1.14e-10 Asthma; LUSC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.57 -7.99 -0.4 2.23e-14 Alzheimer's disease; LUSC cis rs41271951 0.512 rs114222784 chr1:151084781 C/T cg11822372 chr1:151115635 SEMA6C -0.76 -6.95 -0.36 1.98e-11 Blood protein levels; LUSC cis rs1577917 0.710 rs9342041 chr6:86280875 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 7.62 0.39 2.57e-13 Response to antipsychotic treatment; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.02 0.55 6.46e-28 Prudent dietary pattern; LUSC cis rs7107174 0.901 rs11237459 chr11:78056273 A/C cg02023728 chr11:77925099 USP35 0.43 6.59 0.34 1.68e-10 Testicular germ cell tumor; LUSC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.21 0.59 2.51e-32 Cognitive test performance; LUSC cis rs1461503 0.966 rs1461502 chr11:122844927 C/G cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs11642862 0.892 rs11646082 chr16:30911950 T/G cg02466173 chr16:30829666 NA -0.62 -5.92 -0.31 8.19e-9 Tonsillectomy; LUSC cis rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05901451 chr6:126070800 HEY2 -0.77 -13.6 -0.6 7.94e-34 Brugada syndrome; LUSC cis rs60154123 0.772 rs701942 chr1:210429392 C/G cg22029157 chr1:209979665 IRF6 0.58 5.93 0.31 7.41e-9 Coronary artery disease; LUSC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg22920501 chr2:26401640 FAM59B -0.75 -10.55 -0.5 1.18e-22 Gut microbiome composition (summer); LUSC cis rs4363385 0.588 rs6661059 chr1:153027257 A/T cg25856811 chr1:152973957 SPRR3 -0.36 -5.97 -0.31 5.93e-9 Inflammatory skin disease; LUSC cis rs7107174 0.901 rs901105 chr11:77924607 A/C cg02023728 chr11:77925099 USP35 0.52 6.99 0.36 1.54e-11 Testicular germ cell tumor; LUSC cis rs68170813 0.559 rs76534758 chr7:106963262 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.69 -0.47 9.77e-20 Coronary artery disease; LUSC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg16606324 chr3:10149918 C3orf24 0.44 7.01 0.36 1.36e-11 Alzheimer's disease; LUSC cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg17420585 chr12:42539391 GXYLT1 -0.39 -7.85 -0.39 5.79e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9329221 0.657 rs17694485 chr8:10114458 A/T cg27411982 chr8:10470053 RP1L1 0.42 6.14 0.32 2.28e-9 Neuroticism; LUSC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg09359103 chr1:154839909 KCNN3 -0.71 -16.34 -0.67 1.59e-44 Prostate cancer; LUSC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg09367891 chr1:107599246 PRMT6 -0.57 -8.86 -0.44 4.71e-17 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg19052272 chr2:3704530 ALLC -0.65 -11.19 -0.52 6.48e-25 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg09263875 chr16:632152 PIGQ 0.72 13.42 0.59 3.71e-33 Height; LUSC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg22875332 chr1:76189707 ACADM -0.68 -9.23 -0.45 3.21e-18 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs16937 0.618 rs6659069 chr1:205182031 A/G cg00857998 chr1:205179979 DSTYK 0.4 5.73 0.3 2.29e-8 Schizophrenia; LUSC trans rs73191547 0.501 rs6986885 chr8:9978471 G/A cg15556689 chr8:8085844 FLJ10661 0.5 7.26 0.37 2.7e-12 Schizophrenia; LUSC cis rs1348850 0.874 rs952746 chr2:178306584 A/G cg22681709 chr2:178499509 PDE11A -0.49 -8.86 -0.44 4.87e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs372883 0.532 rs425989 chr21:30715275 T/C cg08807101 chr21:30365312 RNF160 -0.5 -7.27 -0.37 2.62e-12 Pancreatic cancer; LUSC cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 5.94 0.31 7.31e-9 Schizophrenia; LUSC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg01579765 chr21:45077557 HSF2BP -0.47 -9.77 -0.47 5.43e-20 Mean corpuscular volume; LUSC cis rs7945718 0.875 rs6486057 chr11:12810338 T/A cg25843174 chr11:12811716 TEAD1 0.32 7.31 0.37 1.98e-12 Educational attainment (years of education); LUSC cis rs385076 0.502 rs13013695 chr2:32391231 G/A cg02381751 chr2:32503542 YIPF4 -0.54 -7.22 -0.37 3.64e-12 Interleukin-18 levels; LUSC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg14019146 chr3:50243930 SLC38A3 0.35 7.9 0.4 3.98e-14 Body mass index; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg11338389 chr11:63742044 COX8A 0.39 6.28 0.32 1.05e-9 Triglycerides; LUSC cis rs3815700 1.000 rs8108840 chr19:33094452 A/C cg02997394 chr19:33096574 ANKRD27 0.82 9.97 0.48 1.14e-20 Eosinophilic esophagitis; LUSC cis rs6429082 0.689 rs10802803 chr1:235709610 A/G cg26050004 chr1:235667680 B3GALNT2 -0.45 -5.99 -0.31 5.54e-9 Adiposity; LUSC cis rs7267979 0.899 rs2104734 chr20:25526668 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.82 0.7 2.19e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9359856 0.510 rs4053618 chr6:90459454 G/A cg13799429 chr6:90582589 CASP8AP2 0.91 10.68 0.5 4.36e-23 Bipolar disorder; LUSC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg02782426 chr3:40428986 ENTPD3 0.41 7.32 0.37 1.82e-12 Renal cell carcinoma; LUSC trans rs79057730 0.527 rs35316052 chr7:802954 C/T cg26647312 chr5:1645268 NA 0.61 5.97 0.31 6.06e-9 Initial pursuit acceleration; LUSC cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.05 0.58 9.94e-32 Platelet count; LUSC cis rs7954584 0.546 rs10840630 chr12:122352445 C/T cg13699009 chr12:122356056 WDR66 0.49 7.38 0.37 1.23e-12 Mean corpuscular volume; LUSC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg02423579 chr7:2872169 GNA12 -0.37 -5.73 -0.3 2.24e-8 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00723019 chr19:48867290 TMEM143;SYNGR4 -0.43 -6.49 -0.33 3.08e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7131987 0.934 rs7316004 chr12:29411698 C/T cg09582351 chr12:29534625 ERGIC2 -0.3 -6.25 -0.32 1.28e-9 QT interval; LUSC cis rs4889855 0.578 rs7216808 chr17:78484187 A/G cg16591659 chr17:78472290 NA -0.48 -7.83 -0.39 6.57e-14 Fractional excretion of uric acid; LUSC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg07741184 chr6:167504864 NA -0.36 -6.49 -0.33 3.11e-10 Crohn's disease; LUSC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg20203395 chr5:56204925 C5orf35 -0.78 -10.35 -0.49 5.89e-22 Initial pursuit acceleration; LUSC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg09904177 chr6:26538194 HMGN4 -0.5 -5.82 -0.3 1.38e-8 Intelligence (multi-trait analysis); LUSC cis rs9398803 0.865 rs9375446 chr6:126835015 G/A cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.97e-9 Male-pattern baldness; LUSC cis rs9322193 0.543 rs9371533 chr6:150210681 G/A cg04369109 chr6:150039330 LATS1 -0.42 -5.79 -0.3 1.66e-8 Lung cancer; LUSC cis rs2625529 0.652 rs2957724 chr15:72248474 A/C cg16672083 chr15:72433130 SENP8 0.48 8.09 0.4 1.08e-14 Red blood cell count; LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg08280861 chr8:58055591 NA 0.57 7.2 0.37 3.94e-12 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.75e-17 Prudent dietary pattern; LUSC cis rs3820068 0.603 rs17448778 chr1:15985306 A/G cg17385448 chr1:15911702 AGMAT 0.38 6.54 0.34 2.26e-10 Systolic blood pressure; LUSC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg17948913 chr5:572064 NA 0.37 5.8 0.3 1.51e-8 Lung disease severity in cystic fibrosis; LUSC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg12564285 chr5:131593104 PDLIM4 0.36 6.78 0.35 5.43e-11 Blood metabolite levels; LUSC trans rs208520 1.000 rs72882086 chr6:66976671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 11.97 0.55 1.05e-27 Exhaled nitric oxide output; LUSC cis rs9837602 1.000 rs9833888 chr3:99723580 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.88 -0.31 1.02e-8 Breast cancer; LUSC cis rs1832871 0.672 rs1342211 chr6:158759496 G/T cg07165851 chr6:158734300 TULP4 0.46 6.97 0.36 1.66e-11 Height; LUSC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg21782813 chr7:2030301 MAD1L1 0.4 6.39 0.33 5.59e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg24881330 chr22:46731750 TRMU 0.92 10.35 0.49 5.7e-22 LDL cholesterol;Cholesterol, total; LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.49 -6.34 -0.33 7.46e-10 Renal function-related traits (BUN); LUSC cis rs6424115 0.729 rs561733 chr1:24049595 T/G cg15997130 chr1:24165203 NA 0.37 5.7 0.3 2.58e-8 Immature fraction of reticulocytes; LUSC trans rs12677056 0.651 rs7011864 chr8:113286963 T/A cg12159992 chr12:102059490 MYBPC1 0.37 6.17 0.32 1.93e-9 Peripheral artery disease; LUSC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg18758796 chr5:131593413 PDLIM4 -0.34 -5.87 -0.31 1.06e-8 Blood metabolite levels; LUSC cis rs734999 0.545 rs7364820 chr1:2556709 G/A cg18932078 chr1:2524107 MMEL1 0.31 6.93 0.35 2.21e-11 Ulcerative colitis; LUSC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg08917208 chr2:24149416 ATAD2B -0.52 -5.89 -0.31 9.48e-9 Lymphocyte counts; LUSC cis rs1595825 0.735 rs16827267 chr2:198924967 G/A cg00982548 chr2:198649783 BOLL -0.55 -6.68 -0.34 1.03e-10 Ulcerative colitis; LUSC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs8017423 0.935 rs59444150 chr14:90767175 T/C cg04374321 chr14:90722782 PSMC1 0.68 10.58 0.5 9.21e-23 Mortality in heart failure; LUSC cis rs7312933 0.618 rs12366848 chr12:42682215 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.51 7.15 0.36 5.44e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05450995 chr12:122460105 BCL7A 0.47 6.39 0.33 5.65e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs765787 0.530 rs11855435 chr15:45522117 G/A cg24006582 chr15:45444508 DUOX1 -0.6 -8.82 -0.43 6.55e-17 Uric acid levels; LUSC cis rs12681288 0.723 rs12545453 chr8:970582 C/T cg15309053 chr8:964076 NA 0.36 7.22 0.37 3.64e-12 Schizophrenia; LUSC cis rs2404602 0.552 rs4886823 chr15:76965402 A/G cg23625390 chr15:77176239 SCAPER -0.62 -9.21 -0.45 3.72e-18 Blood metabolite levels; LUSC cis rs4631830 0.900 rs11006274 chr10:51540291 C/T cg16070123 chr10:51489643 NA 0.47 7.48 0.38 6.56e-13 Prostate-specific antigen levels; LUSC cis rs9359856 0.564 rs56084221 chr6:90365349 T/C cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.96 -0.44 2.37e-17 Bipolar disorder; LUSC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs12410462 0.681 rs75876430 chr1:227661157 A/G cg04117972 chr1:227635322 NA 0.79 7.9 0.4 3.94e-14 Major depressive disorder; LUSC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg04450456 chr4:17643702 FAM184B 0.43 7.21 0.37 3.8e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg21770322 chr7:97807741 LMTK2 0.4 7.07 0.36 9.2e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs8073060 0.859 rs17550268 chr17:33874678 T/C cg19694781 chr19:47549865 TMEM160 0.84 12.49 0.56 1.22e-29 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs6012953 0.845 rs718053 chr20:49196602 G/A cg13958625 chr20:49123093 NA -0.27 -6.09 -0.32 3.19e-9 Vitiligo; LUSC cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.44e-8 Intelligence (multi-trait analysis); LUSC trans rs208520 0.690 rs12213575 chr6:66735989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.09 16.92 0.68 7.94e-47 Exhaled nitric oxide output; LUSC cis rs1670533 0.929 rs6599280 chr4:1063818 A/G cg02018176 chr4:1364513 KIAA1530 0.45 6.22 0.32 1.5e-9 Recombination rate (females); LUSC cis rs8072100 0.745 rs7214410 chr17:45422628 A/G cg25173405 chr17:45401733 C17orf57 -0.4 -6.3 -0.33 9.36e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg07606381 chr6:8435919 SLC35B3 0.73 12.64 0.57 3.36e-30 Motion sickness; LUSC cis rs3087591 0.919 rs11080148 chr17:29609922 T/C cg24425628 chr17:29625626 OMG;NF1 -0.63 -9.03 -0.44 1.43e-17 Hip circumference; LUSC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg19592336 chr6:28129416 ZNF389 0.47 6.19 0.32 1.75e-9 Depression; LUSC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg27170947 chr2:26402098 FAM59B 0.64 9.15 0.45 5.72e-18 Gut microbiome composition (summer); LUSC cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg00852783 chr1:26633632 UBXN11 0.59 9.45 0.46 6.26e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -10.45 -0.5 2.7e-22 Menarche (age at onset); LUSC cis rs7824557 0.628 rs6601580 chr8:11193736 T/G cg21293242 chr8:11204541 TDH 0.32 5.97 0.31 6.04e-9 Retinal vascular caliber; LUSC cis rs1577917 1.000 rs6933377 chr6:86705255 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.55 8.55 0.42 4.55e-16 Response to antipsychotic treatment; LUSC cis rs2124969 0.506 rs10497209 chr2:160985586 A/C cg03641300 chr2:160917029 PLA2R1 -0.47 -5.66 -0.3 3.21e-8 Waist circumference adjusted for body mass index; LUSC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -9.0 -0.44 1.71e-17 Schizophrenia; LUSC cis rs735860 0.712 rs6909592 chr6:53163090 C/G cg10236188 chr6:53219634 NA 0.38 5.95 0.31 6.95e-9 Glaucoma; LUSC cis rs8077889 0.763 rs4792913 chr17:41854497 T/C cg26893861 chr17:41843967 DUSP3 1.09 23.27 0.79 7.1e-72 Triglycerides; LUSC cis rs2120019 1.000 rs60425110 chr15:75333000 T/A cg11632617 chr15:75315747 PPCDC -0.5 -6.45 -0.33 4.03e-10 Blood trace element (Zn levels); LUSC cis rs7605827 0.729 rs35131126 chr2:15537730 A/G cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg16230307 chr14:35515116 FAM177A1 0.81 10.38 0.49 4.58e-22 Psoriasis; LUSC cis rs4964805 0.581 rs7312825 chr12:104188388 G/C cg02344784 chr12:104178138 NT5DC3 0.46 8.86 0.44 4.8e-17 Attention deficit hyperactivity disorder; LUSC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg24675056 chr1:15929824 NA 0.47 8.07 0.4 1.32e-14 Systolic blood pressure; LUSC cis rs6840360 0.550 rs6535806 chr4:152483906 G/A cg22705602 chr4:152727874 NA -0.34 -6.86 -0.35 3.29e-11 Intelligence (multi-trait analysis); LUSC cis rs8016982 0.662 rs7148100 chr14:81678096 A/G cg01989461 chr14:81687754 GTF2A1 0.52 6.85 0.35 3.49e-11 Schizophrenia; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg07157834 chr1:205819609 PM20D1 0.74 12.51 0.56 1.02e-29 Menarche (age at onset); LUSC cis rs983392 0.792 rs1303621 chr11:59890674 A/G cg24026212 chr11:59952134 MS4A6A -0.31 -5.79 -0.3 1.61e-8 Alzheimer's disease (late onset); LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.25 0.45 2.66e-18 Prudent dietary pattern; LUSC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg21573476 chr21:45109991 RRP1B -0.42 -6.56 -0.34 2.09e-10 Mean corpuscular volume; LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg00814883 chr7:100076585 TSC22D4 -0.73 -9.8 -0.47 4.39e-20 Platelet count; LUSC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg14440974 chr22:39074834 NA -0.35 -5.86 -0.31 1.11e-8 Menopause (age at onset); LUSC trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg15934090 chr1:100435551 SLC35A3 0.48 8.3 0.41 2.61e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg26384229 chr12:38710491 ALG10B 0.93 17.54 0.69 2.66e-49 Heart rate; LUSC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg27541892 chr1:1571801 CDK11B -0.51 -8.19 -0.41 5.45e-15 Body mass index; LUSC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg12463550 chr7:65579703 CRCP 0.52 7.54 0.38 4.45e-13 Aortic root size; LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg02423579 chr7:2872169 GNA12 -0.44 -6.37 -0.33 6.2e-10 Height; LUSC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.64 -0.39 2.27e-13 Developmental language disorder (linguistic errors); LUSC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg09509183 chr1:209979624 IRF6 0.37 5.69 0.3 2.84e-8 Monobrow; LUSC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.6 -0.38 3.09e-13 Developmental language disorder (linguistic errors); LUSC cis rs4561483 0.583 rs11075032 chr16:12004450 C/T cg08843971 chr16:11963173 GSPT1 0.42 6.35 0.33 7e-10 Testicular germ cell tumor; LUSC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg00338735 chr4:53728038 RASL11B 0.48 5.67 0.3 3.03e-8 Optic nerve measurement (cup area); LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg27170947 chr2:26402098 FAM59B 0.72 10.77 0.51 2.12e-23 Gut microbiome composition (summer); LUSC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.54 -0.42 4.74e-16 Personality dimensions; LUSC trans rs61931739 0.513 rs1463634 chr12:33899621 A/G cg26384229 chr12:38710491 ALG10B 0.59 9.42 0.46 7.54e-19 Morning vs. evening chronotype; LUSC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg21770322 chr7:97807741 LMTK2 0.42 7.29 0.37 2.27e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2548003 0.565 rs2554894 chr5:28762951 A/G cg22863700 chr5:28928346 NA 0.45 6.38 0.33 6.04e-10 Hip geometry; LUSC cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg02527881 chr3:46936655 PTH1R 0.39 6.73 0.35 7.27e-11 Colorectal cancer; LUSC cis rs6500395 0.962 rs9937568 chr16:48612361 C/T cg04672837 chr16:48644449 N4BP1 -0.5 -7.4 -0.38 1.13e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg02574844 chr11:5959923 NA -0.43 -6.14 -0.32 2.37e-9 DNA methylation (variation); LUSC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg24675056 chr1:15929824 NA 0.46 7.91 0.4 3.85e-14 Systolic blood pressure; LUSC cis rs6570726 0.905 rs375692 chr6:145840368 A/G cg23711669 chr6:146136114 FBXO30 0.73 12.89 0.58 3.92e-31 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22433398 chr13:27825486 RPL21;RPL21P28 0.43 6.64 0.34 1.25e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09067793 chr2:73461223 CCT7;C2orf7 -0.48 -7.06 -0.36 9.53e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs478304 0.593 rs4645927 chr11:65482827 C/T cg05805236 chr11:65401703 PCNXL3 -0.64 -10.53 -0.5 1.41e-22 Acne (severe); LUSC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg01416388 chr22:39784598 NA -0.44 -7.32 -0.37 1.83e-12 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T ch.21.33444458F chr21:34522588 NA 0.38 6.5 0.34 2.96e-10 Triglycerides; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01355476 chr16:85722306 GINS2 0.75 5.95 0.31 6.89e-9 Cognitive performance; LUSC cis rs921968 0.612 rs832810 chr2:219322430 T/C cg02176678 chr2:219576539 TTLL4 0.59 10.58 0.5 9.38e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg16006841 chr5:176797999 RGS14 0.63 9.75 0.47 6.15e-20 Urinary electrolytes (magnesium/calcium ratio); LUSC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11890956 chr21:40555474 PSMG1 1.03 21.08 0.76 2.6e-63 Cognitive function; LUSC cis rs7824557 0.564 rs2736304 chr8:11236964 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.78 -0.3 1.74e-8 Retinal vascular caliber; LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg00106254 chr7:1943704 MAD1L1 -0.41 -5.89 -0.31 9.36e-9 Bipolar disorder and schizophrenia; LUSC cis rs2120019 0.567 rs72625793 chr15:75207083 A/G cg17294928 chr15:75287854 SCAMP5 -0.75 -8.75 -0.43 1.07e-16 Blood trace element (Zn levels); LUSC cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg24642439 chr20:33292090 TP53INP2 0.49 7.34 0.37 1.62e-12 Glomerular filtration rate (creatinine); LUSC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg20891283 chr12:69753455 YEATS4 0.82 15.09 0.64 1.34e-39 Blood protein levels; LUSC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg04539111 chr16:67997858 SLC12A4 -0.46 -6.27 -0.32 1.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs56399783 0.901 rs73051415 chr7:2850643 C/T cg14895029 chr7:2775587 GNA12 0.51 6.35 0.33 6.94e-10 Childhood ear infection; LUSC cis rs10203711 1.000 rs1810140 chr2:239568163 T/C cg14580085 chr2:239553406 NA 0.42 7.1 0.36 7.48e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.567 rs7742692 chr6:150213499 A/G cg13206674 chr6:150067644 NUP43 0.44 6.64 0.34 1.3100000000000001e-10 Lung cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07843956 chr16:692375 FAM195A 0.8 6.31 0.33 8.91e-10 Cognitive performance; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg06145435 chr7:1022769 CYP2W1 -0.29 -6.01 -0.31 4.97e-9 Longevity;Endometriosis; LUSC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg17470723 chr8:74884337 TCEB1 0.52 8.16 0.41 6.79e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4141404 0.851 rs5749222 chr22:31556759 C/G cg22777020 chr22:31556080 RNF185 -0.51 -6.81 -0.35 4.49e-11 Paclitaxel-induced neuropathy; LUSC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg13939156 chr17:80058883 NA -0.34 -6.75 -0.35 6.59e-11 Life satisfaction; LUSC cis rs12410462 0.581 rs12402691 chr1:227543693 G/A cg04117972 chr1:227635322 NA 0.61 6.74 0.35 7.09e-11 Major depressive disorder; LUSC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.65 9.88 0.48 2.25e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.33 0.37 1.7e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs17253792 0.915 rs76957332 chr14:56195370 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.79 -0.35 5.15e-11 Putamen volume; LUSC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg12311346 chr5:56204834 C5orf35 -0.62 -9.46 -0.46 5.79e-19 Breast cancer;Breast cancer (early onset); LUSC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg20476274 chr7:133979776 SLC35B4 0.82 14.95 0.63 4.92e-39 Mean platelet volume; LUSC cis rs56283067 0.887 rs12197593 chr6:44740895 C/T cg20913747 chr6:44695427 NA -0.48 -8.07 -0.4 1.32e-14 Total body bone mineral density; LUSC cis rs7223966 1.000 rs9903903 chr17:61762044 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.33 0.37 1.75e-12 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs2983496 1.000 rs2983534 chr6:166015625 G/A cg20192747 chr18:44774846 NA -0.49 -6.39 -0.33 5.64e-10 Cortisol levels (saliva); LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.47 0.42 7.99e-16 Prudent dietary pattern; LUSC trans rs6502050 0.698 rs6502076 chr17:80121978 A/G cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs939658 1.000 rs8033963 chr15:79455350 C/T cg17916960 chr15:79447300 NA 0.47 9.51 0.46 3.94e-19 Refractive error; LUSC cis rs10791097 0.694 rs4937583 chr11:130741606 A/G cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2070488 0.662 rs7372545 chr3:38507570 T/G cg24069376 chr3:38537580 EXOG 0.35 6.22 0.32 1.47e-9 Electrocardiographic conduction measures; LUSC cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC cis rs1568889 1.000 rs6484346 chr11:28040767 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.5 0.46 4.34e-19 Bipolar disorder; LUSC cis rs10761482 0.861 rs10761488 chr10:62105992 C/T cg18175470 chr10:62150864 ANK3 -0.47 -6.78 -0.35 5.36e-11 Schizophrenia; LUSC cis rs7512552 0.839 rs696616 chr1:150336173 G/A cg15654264 chr1:150340011 RPRD2 0.67 11.18 0.52 7.2e-25 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9937943 0.720 rs112685216 chr16:74609517 G/A cg01733217 chr16:74700730 RFWD3 0.61 6.62 0.34 1.39e-10 Neutrophil percentage of white cells; LUSC cis rs6740322 0.748 rs13402621 chr2:43458611 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -6.97 -0.36 1.67e-11 Coronary artery disease; LUSC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.37 0.33 6.32e-10 Renal cell carcinoma; LUSC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.81e-9 Vitiligo; LUSC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg00409905 chr10:38381863 ZNF37A -0.36 -6.27 -0.32 1.12e-9 Extrinsic epigenetic age acceleration; LUSC cis rs61990749 0.544 rs176979 chr14:78198072 A/C cg02301378 chr14:78227641 SNW1;C14orf178 0.59 6.52 0.34 2.63e-10 Fibroblast growth factor basic levels; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.62 10.3 0.49 8.92e-22 Lymphocyte counts; LUSC cis rs9650657 0.645 rs9969657 chr8:10515278 A/G cg21775007 chr8:11205619 TDH 0.4 5.91 0.31 8.48e-9 Neuroticism; LUSC trans rs8002861 0.870 rs2121030 chr13:44444574 C/T cg12856521 chr11:46389249 DGKZ -0.41 -6.4 -0.33 5.11e-10 Leprosy; LUSC cis rs8072100 0.544 rs9284377 chr17:45386412 C/T cg08085267 chr17:45401833 C17orf57 -0.49 -7.45 -0.38 8.02e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4660306 0.961 rs3748643 chr1:45965703 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.22 -0.37 3.6e-12 Homocysteine levels; LUSC cis rs35883536 0.609 rs1855631 chr1:101040010 C/T cg06223162 chr1:101003688 GPR88 -0.47 -8.89 -0.44 3.92e-17 Monocyte count; LUSC cis rs2235544 0.579 rs1537322 chr1:54482306 G/T cg25741118 chr1:54482237 LDLRAD1 -0.33 -7.61 -0.38 2.91e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs637571 0.726 rs526631 chr11:65681965 T/G cg04055107 chr11:65626734 MUS81;CFL1 -0.47 -6.29 -0.33 9.7e-10 Eosinophil percentage of white cells; LUSC cis rs10193935 0.901 rs72800020 chr2:42655615 A/G cg27598129 chr2:42591480 NA -0.67 -8.74 -0.43 1.12e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg15448220 chr1:150897856 SETDB1 0.42 5.99 0.31 5.28e-9 Melanoma; LUSC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg10253484 chr15:75165896 SCAMP2 -0.45 -6.43 -0.33 4.29e-10 Breast cancer; LUSC cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg05347473 chr6:146136440 FBXO30 -0.51 -8.74 -0.43 1.19e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg07395648 chr5:131743802 NA 0.47 7.49 0.38 6.24e-13 Breast cancer;Mosquito bite size; LUSC cis rs478304 0.718 rs1151490 chr11:65390485 A/C cg05805236 chr11:65401703 PCNXL3 0.49 7.96 0.4 2.65e-14 Acne (severe); LUSC cis rs7191700 0.511 rs243330 chr16:11350991 C/T cg00044050 chr16:11439710 C16orf75 0.67 11.51 0.53 4.67e-26 Multiple sclerosis; LUSC cis rs2806561 0.704 rs6426779 chr1:23310485 T/C cg19743168 chr1:23544995 NA -0.38 -7.74 -0.39 1.21e-13 Height; LUSC cis rs9837602 1.000 rs13323143 chr3:99811553 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.07 -0.32 3.4e-9 Breast cancer; LUSC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg02187348 chr16:89574699 SPG7 0.47 7.13 0.36 6.16e-12 Multiple myeloma (IgH translocation); LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg07777115 chr5:623756 CEP72 -0.45 -5.7 -0.3 2.62e-8 Lung disease severity in cystic fibrosis; LUSC cis rs62400317 0.793 rs12210230 chr6:45344854 T/A cg20913747 chr6:44695427 NA -0.48 -7.81 -0.39 7.39e-14 Total body bone mineral density; LUSC cis rs13315871 1.000 rs13315871 chr3:58381287 G/A cg12435725 chr3:58293450 RPP14 -0.73 -7.27 -0.37 2.64e-12 Cholesterol, total; LUSC cis rs9788682 0.747 rs2036533 chr15:78781687 G/A cg06917634 chr15:78832804 PSMA4 -0.48 -5.94 -0.31 7.15e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg13256891 chr4:100009986 ADH5 0.5 6.87 0.35 3.08e-11 Smoking initiation; LUSC cis rs6964587 0.933 rs6465350 chr7:91768615 G/A cg17063962 chr7:91808500 NA 0.62 9.91 0.48 1.81e-20 Breast cancer; LUSC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg18099408 chr3:52552593 STAB1 -0.35 -5.88 -0.31 9.83e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg22535103 chr8:58192502 C8orf71 -0.74 -9.26 -0.45 2.46e-18 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg07677032 chr17:61819896 STRADA 0.53 8.86 0.44 4.89e-17 Prudent dietary pattern; LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg13395646 chr4:1353034 KIAA1530 0.56 8.12 0.41 9.3e-15 Longevity; LUSC cis rs10782582 0.609 rs112205173 chr1:76310100 C/T cg03433033 chr1:76189801 ACADM -0.42 -6.19 -0.32 1.81e-9 Daytime sleep phenotypes; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.66 0.39 2.05e-13 Prudent dietary pattern; LUSC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Tonsillectomy; LUSC cis rs2070488 0.775 rs11926767 chr3:38527913 A/G cg24069376 chr3:38537580 EXOG -0.41 -8.11 -0.41 1e-14 Electrocardiographic conduction measures; LUSC cis rs1691799 0.899 rs1168318 chr12:66745269 A/G cg16791601 chr12:66731901 HELB 0.73 12.97 0.58 1.99e-31 White blood cell count (basophil); LUSC cis rs4843747 0.749 rs13333619 chr16:88072076 C/T cg09044154 chr16:88155775 NA -0.55 -7.27 -0.37 2.59e-12 Menopause (age at onset); LUSC cis rs1953600 0.805 rs2819947 chr10:81947757 T/C cg00277334 chr10:82204260 NA 0.45 7.12 0.36 6.72e-12 Sarcoidosis; LUSC cis rs7586879 0.559 rs13387729 chr2:25076126 A/G cg04586622 chr2:25135609 ADCY3 0.39 8.21 0.41 4.94e-15 Body mass index; LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.44 0.53 8.42e-26 Menopause (age at onset); LUSC cis rs11758351 1.000 rs11755210 chr6:26202768 C/T cg23601095 chr6:26197514 HIST1H3D 0.75 7.59 0.38 3.21e-13 Gout;Renal underexcretion gout; LUSC cis rs9341808 0.628 rs9294172 chr6:80918561 G/A cg08355045 chr6:80787529 NA 0.49 8.32 0.41 2.25e-15 Sitting height ratio; LUSC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg03233332 chr7:66118400 NA 0.42 6.09 0.32 3.02e-9 Aortic root size; LUSC cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg13531842 chr10:38383804 ZNF37A -0.44 -6.77 -0.35 5.69e-11 Extrinsic epigenetic age acceleration; LUSC cis rs763121 0.925 rs1043312 chr22:39131727 T/G cg06022373 chr22:39101656 GTPBP1 0.7 11.3 0.53 2.81e-25 Menopause (age at onset); LUSC cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg11530693 chr1:120165357 ZNF697 -0.63 -9.75 -0.47 6.12e-20 Systemic lupus erythematosus; LUSC cis rs7523050 0.643 rs17621922 chr1:109404454 C/T cg08274380 chr1:109419600 GPSM2 1.0 10.54 0.5 1.3e-22 Fat distribution (HIV); LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 4.92e-10 Systemic lupus erythematosus; LUSC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -7.35 -0.37 1.51e-12 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg13393036 chr8:95962371 TP53INP1 -0.47 -9.69 -0.47 9.74e-20 Type 2 diabetes; LUSC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 9.04 0.44 1.28e-17 Tonsillectomy; LUSC cis rs8017423 0.605 rs3742673 chr14:90735707 C/T cg04374321 chr14:90722782 PSMC1 0.46 6.57 0.34 1.97e-10 Mortality in heart failure; LUSC cis rs1595825 0.891 rs35817167 chr2:198718928 A/T cg10547527 chr2:198650123 BOLL -0.5 -5.91 -0.31 8.37e-9 Ulcerative colitis; LUSC cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg24692254 chr21:30365293 RNF160 -0.79 -14.42 -0.62 5.61e-37 Dental caries; LUSC cis rs9341808 0.667 rs2490244 chr6:80891112 A/T cg08355045 chr6:80787529 NA 0.47 8.02 0.4 1.86e-14 Sitting height ratio; LUSC cis rs2629540 0.847 rs10901811 chr10:126417914 G/A cg08799069 chr10:126477246 METTL10 0.64 9.04 0.44 1.32e-17 Cocaine dependence; LUSC cis rs1595825 1.000 rs73058820 chr2:198864358 A/G cg19156104 chr2:198669113 PLCL1 -0.46 -5.71 -0.3 2.44e-8 Ulcerative colitis; LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg24642844 chr7:1081250 C7orf50 -0.81 -10.9 -0.51 7.43e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg23093090 chr10:104574429 C10orf26 -0.44 -7.85 -0.39 5.76e-14 Arsenic metabolism; LUSC cis rs17433780 0.964 rs12121223 chr1:89481583 C/T cg09516651 chr1:89888402 LOC400759 0.54 8.98 0.44 1.96e-17 Carotid intima media thickness; LUSC trans rs1499614 1.000 rs60326618 chr7:66166358 G/A cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg08470875 chr2:26401718 FAM59B -0.72 -9.9 -0.48 1.91e-20 Gut microbiome composition (summer); LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg01516881 chr6:292596 DUSP22 -0.52 -7.68 -0.39 1.79e-13 Menopause (age at onset); LUSC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg16624210 chr5:671434 TPPP 0.5 6.54 0.34 2.35e-10 Obesity-related traits; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg09177884 chr7:1199841 ZFAND2A -0.47 -6.27 -0.32 1.1e-9 Longevity;Endometriosis; LUSC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.61e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg27165867 chr14:105738592 BRF1 -0.51 -7.44 -0.38 8.77e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs10203711 0.966 rs10184252 chr2:239598164 A/G cg14580085 chr2:239553406 NA 0.43 7.17 0.37 4.81e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs1459104 0.704 rs12806568 chr11:54892378 G/A cg03929089 chr4:120376271 NA 0.74 6.38 0.33 5.96e-10 Body mass index; LUSC trans rs60843830 1.000 rs59937473 chr2:271797 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.4 0.49 3.83e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs1941687 0.831 rs62091190 chr18:31387700 C/T cg27147174 chr7:100797783 AP1S1 -0.46 -6.88 -0.35 2.97e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs13315871 0.790 rs28502788 chr3:58296208 A/T cg12435725 chr3:58293450 RPP14 -0.69 -7.16 -0.36 5.24e-12 Cholesterol, total; LUSC cis rs782590 0.774 rs782630 chr2:55899425 T/C cg03859395 chr2:55845619 SMEK2 0.86 15.72 0.65 4.52e-42 Metabolic syndrome; LUSC cis rs4343996 0.676 rs4358698 chr7:3378616 A/T cg21248987 chr7:3385318 SDK1 -0.37 -6.22 -0.32 1.49e-9 Motion sickness; LUSC cis rs4720118 0.875 rs9784973 chr7:33389689 A/G cg22798885 chr7:33102694 NT5C3 0.45 6.2 0.32 1.64e-9 Leprosy; LUSC cis rs1957429 0.901 rs8008745 chr14:65351593 C/G cg23373153 chr14:65346875 NA 1.03 12.37 0.56 3.41e-29 Pediatric areal bone mineral density (radius); LUSC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg03233332 chr7:66118400 NA -0.4 -5.81 -0.3 1.47e-8 Aortic root size; LUSC cis rs739496 0.542 rs7399113 chr12:111792848 G/A cg10833066 chr12:111807467 FAM109A 0.61 11.97 0.55 1.05e-27 Platelet count; LUSC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg06238570 chr21:40685208 BRWD1 0.45 6.94 0.36 2.04e-11 Cognitive function; LUSC cis rs35146811 0.735 rs11764176 chr7:99786964 G/T cg13334819 chr7:99746414 C7orf59 -0.5 -6.73 -0.35 7.41e-11 Coronary artery disease; LUSC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.53 -10.09 -0.48 4.6e-21 Monocyte percentage of white cells; LUSC cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg00484396 chr16:3507460 NAT15 0.49 7.27 0.37 2.55e-12 Body mass index (adult); LUSC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.76 0.68 3.58e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9463078 0.753 rs10948186 chr6:44903248 C/T cg25276700 chr6:44698697 NA -0.3 -5.94 -0.31 7.12e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg17376030 chr22:41985996 PMM1 -0.46 -5.7 -0.3 2.67e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs17270561 0.666 rs12209856 chr6:25793673 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 6.7 0.34 8.86e-11 Iron status biomarkers; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg20135002 chr11:47629003 NA -0.51 -7.72 -0.39 1.37e-13 Subjective well-being; LUSC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg16743903 chr16:89593216 SPG7 -0.38 -5.98 -0.31 5.71e-9 Multiple myeloma (IgH translocation); LUSC cis rs1372520 0.748 rs1471484 chr4:90754313 C/T cg01966878 chr4:90757139 SNCA -0.43 -6.0 -0.31 5.14e-9 Neuroticism; LUSC cis rs614226 0.935 rs3887875 chr12:120895749 A/G cg01236616 chr12:121019343 POP5 -1.33 -21.45 -0.76 8.9e-65 Type 1 diabetes nephropathy; LUSC cis rs9329221 0.527 rs34259385 chr8:10325456 C/T cg21775007 chr8:11205619 TDH -0.43 -5.79 -0.3 1.65e-8 Neuroticism; LUSC cis rs7527798 0.592 rs11118345 chr1:207854827 A/T cg09232269 chr1:207846808 CR1L -0.3 -6.24 -0.32 1.3e-9 Erythrocyte sedimentation rate; LUSC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.84 -0.3 1.22e-8 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs7568458 0.905 rs10172544 chr2:85788270 C/A cg17127132 chr2:85788382 GGCX 0.46 7.55 0.38 4.3e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22228677 chr17:17495359 PEMT -0.43 -6.43 -0.33 4.52e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg16393715 chr7:1948819 MAD1L1 0.33 5.9 0.31 8.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs73206853 0.841 rs74728497 chr12:111020179 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 6.54 0.34 2.3e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs3820068 0.705 rs72643701 chr1:15866219 G/A cg17385448 chr1:15911702 AGMAT 0.38 5.73 0.3 2.22e-8 Systolic blood pressure; LUSC cis rs6494488 0.500 rs72744749 chr15:65062819 G/C cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs9361491 0.508 rs9343786 chr6:79414728 A/C cg23262351 chr6:79576851 IRAK1BP1 0.38 5.67 0.3 3.09e-8 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 7.16 0.36 5.32e-12 Platelet count; LUSC cis rs735860 0.712 rs9395855 chr6:53176765 G/T cg10236188 chr6:53219634 NA -0.4 -6.41 -0.33 4.94e-10 Glaucoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03635536 chr5:96271340 LNPEP -0.48 -6.18 -0.32 1.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.16 -0.49 2.59e-21 Menarche (age at onset); LUSC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 10.41 0.5 3.53e-22 Eosinophil percentage of white cells; LUSC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg11752832 chr7:134001865 SLC35B4 0.6 9.54 0.46 3.05e-19 Mean platelet volume; LUSC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg22920501 chr2:26401640 FAM59B -0.74 -10.47 -0.5 2.22e-22 Gut microbiome composition (summer); LUSC cis rs2580764 0.598 rs7340476 chr2:55227346 G/C cg09592903 chr2:55203963 RTN4 -0.49 -10.11 -0.48 4e-21 Mean platelet volume; LUSC cis rs7605827 0.930 rs4668900 chr2:15511740 T/C cg19274914 chr2:15703543 NA 0.46 8.95 0.44 2.45e-17 Educational attainment (years of education); LUSC cis rs1997103 0.954 rs9649854 chr7:55410213 G/A cg17469321 chr7:55412551 NA 0.64 10.38 0.49 4.6e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs76878669 0.561 rs7940980 chr11:66172910 C/T cg18002602 chr11:66138449 SLC29A2 -0.49 -8.53 -0.42 5e-16 Educational attainment (years of education); LUSC cis rs2625529 0.617 rs6494973 chr15:72145728 A/T cg16672083 chr15:72433130 SENP8 0.49 7.91 0.4 3.79e-14 Red blood cell count; LUSC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.34 -0.42 1.93e-15 Height; LUSC cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg16586182 chr3:47516702 SCAP -0.52 -8.13 -0.41 8.41e-15 Colorectal cancer; LUSC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg23791538 chr6:167370224 RNASET2 0.41 6.73 0.35 7.6e-11 Crohn's disease; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg17567317 chr22:38349719 POLR2F;C22orf23 0.48 6.42 0.33 4.81e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6840360 1.000 rs9998462 chr4:152646548 T/A cg22705602 chr4:152727874 NA -0.28 -6.09 -0.32 3.03e-9 Intelligence (multi-trait analysis); LUSC cis rs9467711 0.606 rs16891727 chr6:26488860 C/A cg12826209 chr6:26865740 GUSBL1 0.68 5.9 0.31 8.88e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg18252515 chr7:66147081 NA 1.24 14.24 0.61 2.72e-36 Diabetic kidney disease; LUSC cis rs9463078 0.605 rs9472411 chr6:44943183 T/C cg25276700 chr6:44698697 NA 0.29 6.01 0.31 4.8e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs644799 0.710 rs10831433 chr11:95519787 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.3 0.62 1.64e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs79976124 0.837 rs11751994 chr6:66644028 A/C cg07460842 chr6:66804631 NA 0.71 8.87 0.44 4.36e-17 Type 2 diabetes; LUSC cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg16339924 chr4:17578868 LAP3 0.59 9.12 0.45 7.3e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4974559 1.000 rs4974559 chr4:1380848 C/T cg02980000 chr4:1222292 CTBP1 -0.59 -7.42 -0.38 9.88e-13 Systolic blood pressure; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg02951883 chr7:2050386 MAD1L1 -0.46 -7.89 -0.4 4.32e-14 Bipolar disorder and schizophrenia; LUSC cis rs7568458 0.905 rs59877521 chr2:85759494 C/T cg17127132 chr2:85788382 GGCX 0.49 7.89 0.4 4.47e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg10909506 chr17:38081995 ORMDL3 0.34 6.15 0.32 2.26e-9 Self-reported allergy; LUSC cis rs9302690 0.557 rs223869 chr16:57494992 C/A cg16753122 chr16:57506917 DOK4 0.58 7.21 0.37 3.87e-12 Blood protein levels; LUSC cis rs2840044 1.000 rs225277 chr17:33973311 G/A cg05299278 chr17:33885742 SLFN14 0.29 5.92 0.31 7.9e-9 Response to radiotherapy in cancer (late toxicity); LUSC trans rs17158675 1.000 rs73380837 chr7:83783721 C/T cg08326515 chr4:111564605 NA 0.82 6.06 0.31 3.76e-9 Obesity-related traits; LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg23758822 chr17:41437982 NA 1.06 20.29 0.74 3.2e-60 Menopause (age at onset); LUSC cis rs243505 0.691 rs243483 chr7:148449163 A/G cg09806900 chr7:148480153 CUL1 -0.54 -7.21 -0.37 3.75e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg09796270 chr17:17721594 SREBF1 -0.43 -7.61 -0.38 2.91e-13 Total body bone mineral density; LUSC cis rs62027291 0.654 rs11634136 chr15:77063039 A/G cg26408565 chr15:76604113 ETFA 0.78 7.02 0.36 1.25e-11 Plateletcrit; LUSC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg11812906 chr14:75593930 NEK9 0.66 11.23 0.52 4.9e-25 Height; LUSC trans rs3942852 0.759 rs905475 chr11:48149755 C/T cg15704280 chr7:45808275 SEPT13 -0.6 -7.36 -0.37 1.42e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg12963246 chr6:28129442 ZNF389 -0.5 -6.91 -0.35 2.4e-11 Depression; LUSC cis rs7819412 1.000 rs2409722 chr8:11039816 T/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.73 -0.3 2.29e-8 Triglycerides; LUSC cis rs2762353 1.000 rs2762353 chr6:25794431 A/G cg12310025 chr6:25882481 NA -0.43 -7.4 -0.38 1.12e-12 Blood metabolite levels; LUSC cis rs13631 0.894 rs7856589 chr9:140003921 A/G cg03717367 chr9:139980219 LOC100289341;MAN1B1 -0.51 -8.92 -0.44 3.03e-17 Cerebrospinal fluid biomarker levels; LUSC cis rs870825 0.616 rs7667409 chr4:185650941 C/T cg04058563 chr4:185651563 MLF1IP -0.85 -13.08 -0.58 7.57e-32 Blood protein levels; LUSC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 6.83e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs1997103 0.954 rs2030807 chr7:55378485 A/G cg20935933 chr6:143382018 AIG1 0.52 7.33 0.37 1.8e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs16976116 0.851 rs11855907 chr15:55494634 A/C cg11288833 chr15:55489084 RSL24D1 0.49 5.8 0.3 1.53e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1997103 1.000 rs6973337 chr7:55411534 T/C cg17469321 chr7:55412551 NA 0.64 10.19 0.49 2.02e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2200578 1.000 rs116648076 chr2:99882347 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.53 6.22 0.32 1.53e-9 IgG glycosylation; LUSC cis rs12586317 0.620 rs12588810 chr14:35554484 C/T cg16230307 chr14:35515116 FAM177A1 0.81 10.13 0.48 3.28e-21 Psoriasis; LUSC cis rs10791097 0.582 rs2282578 chr11:130735691 A/T cg12179176 chr11:130786555 SNX19 0.82 14.03 0.61 1.8e-35 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg18252515 chr7:66147081 NA -1.26 -14.54 -0.62 1.94e-37 Gout; LUSC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.7 0.39 1.54e-13 Vitiligo; LUSC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg06808227 chr14:105710500 BRF1 -0.66 -10.28 -0.49 1.03e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg24110177 chr3:50126178 RBM5 -0.67 -11.48 -0.53 5.97e-26 Body mass index; LUSC cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg09307838 chr4:120376055 NA 0.78 11.32 0.53 2.25e-25 Corneal astigmatism; LUSC cis rs3862030 0.720 rs11593971 chr10:104234090 C/G cg22532475 chr10:104410764 TRIM8 0.25 5.82 0.3 1.38e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg03264133 chr6:25882463 NA -0.5 -9.11 -0.45 7.57e-18 Blood metabolite levels; LUSC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg18876405 chr7:65276391 NA 0.53 8.35 0.42 1.81e-15 Aortic root size; LUSC cis rs2011503 0.941 rs10403273 chr19:19372968 C/G cg11584989 chr19:19387371 SF4 0.6 7.33 0.37 1.78e-12 Bipolar disorder; LUSC cis rs9420 0.884 rs644883 chr11:57663522 C/G cg23127183 chr11:57508653 C11orf31 0.51 7.23 0.37 3.27e-12 Schizophrenia; LUSC cis rs11264799 0.520 rs2777965 chr1:157550417 A/C cg18268488 chr1:157545234 FCRL4 0.39 7.63 0.39 2.42e-13 IgA nephropathy; LUSC cis rs472402 0.580 rs3822430 chr5:6651970 A/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.45 -6.54 -0.34 2.24e-10 Response to amphetamines; LUSC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg16447950 chr5:562315 NA -0.56 -7.67 -0.39 1.86e-13 Ulcerative colitis; LUSC cis rs4595586 0.545 rs4768505 chr12:39380338 C/A cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs7809950 0.954 rs2520247 chr7:107143946 A/T cg23024343 chr7:107201750 COG5 -0.55 -8.81 -0.43 6.77e-17 Coronary artery disease; LUSC cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg24642439 chr20:33292090 TP53INP2 -0.5 -7.59 -0.38 3.27e-13 Glomerular filtration rate (creatinine); LUSC trans rs2228479 0.850 rs12598276 chr16:89829196 G/C cg24644049 chr4:85504048 CDS1 0.88 7.56 0.38 3.94e-13 Skin colour saturation; LUSC cis rs9467773 0.565 rs6925047 chr6:26521435 C/G cg05738196 chr6:26577821 NA 0.74 12.18 0.55 1.72e-28 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg14004847 chr7:1930337 MAD1L1 -0.55 -8.71 -0.43 1.47e-16 Bipolar disorder and schizophrenia; LUSC cis rs72615157 0.539 rs12673441 chr7:99670328 A/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.47 6.67 0.34 1.09e-10 Lung function (FEV1/FVC); LUSC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg03233332 chr7:66118400 NA -0.42 -6.09 -0.32 3.02e-9 Aortic root size; LUSC cis rs681343 1.000 rs516246 chr19:49206172 C/T cg21064579 chr19:49206444 FUT2 0.44 8.41 0.42 1.22e-15 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; LUSC cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg00376283 chr12:123451042 ABCB9 0.73 9.45 0.46 5.92e-19 Height;Educational attainment;Head circumference (infant); LUSC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -9.56 -0.46 2.63e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11264799 0.520 rs849814 chr1:157542216 G/A cg18268488 chr1:157545234 FCRL4 0.38 7.36 0.37 1.4e-12 IgA nephropathy; LUSC trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg17470723 chr8:74884337 TCEB1 0.53 8.28 0.41 3.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.52 6.98 0.36 1.63e-11 Gut microbiome composition (summer); LUSC cis rs9462027 0.628 rs1125341 chr6:34786305 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.74 -0.3 2.13e-8 Systemic lupus erythematosus; LUSC cis rs6690583 0.512 rs7547224 chr1:85456902 T/C cg11262906 chr1:85462892 MCOLN2 0.7 6.47 0.33 3.56e-10 Serum sulfate level; LUSC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg16414030 chr3:133502952 NA 0.41 6.4 0.33 5.14e-10 Iron status biomarkers; LUSC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 -0.49 -7.53 -0.38 4.74e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg15744005 chr10:104629667 AS3MT -0.27 -5.72 -0.3 2.34e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs5758659 0.652 rs133335 chr22:42416056 C/T cg04733989 chr22:42467013 NAGA -0.45 -7.2 -0.37 4.03e-12 Cognitive function; LUSC trans rs890100 0.673 rs35017848 chr2:56664100 A/T cg01657744 chr10:88471748 LDB3 0.43 5.96 0.31 6.28e-9 Gut microbiome composition (summer); LUSC cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg20503657 chr10:835505 NA 0.45 6.28 0.32 1.07e-9 Response to angiotensin II receptor blocker therapy; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg24868830 chr4:140374821 RAB33B 0.39 6.36 0.33 6.71e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg04267008 chr7:1944627 MAD1L1 -0.65 -10.0 -0.48 9.03e-21 Bipolar disorder and schizophrenia; LUSC cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -7.97 -0.4 2.53e-14 Mood instability; LUSC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg06454157 chr6:167490870 NA -0.25 -6.02 -0.31 4.6e-9 Crohn's disease; LUSC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.45 -7.12 -0.36 6.52e-12 Alzheimer's disease (late onset); LUSC trans rs3857536 0.813 rs7743965 chr6:66941346 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs7833986 0.501 rs17812659 chr8:56889862 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.67 10.23 0.49 1.54e-21 Height; LUSC cis rs9653442 0.675 rs961788 chr2:100641459 T/C cg22139774 chr2:100720529 AFF3 -0.46 -7.82 -0.39 7.1e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1003719 0.788 rs4411798 chr21:38453183 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.66 10.81 0.51 1.54e-23 Eye color traits; LUSC cis rs11958404 0.932 rs72816556 chr5:157424412 C/G cg05962755 chr5:157440814 NA 0.49 6.04 0.31 4.04e-9 IgG glycosylation; LUSC cis rs1797081 0.840 rs10904820 chr10:16848473 A/G cg23933602 chr10:16859644 RSU1 0.98 20.64 0.75 1.33e-61 Platelet distribution width; LUSC cis rs12155623 0.803 rs6987879 chr8:49808062 T/C cg22283653 chr8:49824208 NA -0.37 -7.16 -0.36 5.09e-12 Sudden cardiac arrest; LUSC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg23711669 chr6:146136114 FBXO30 0.73 11.36 0.53 1.63e-25 Lobe attachment (rater-scored or self-reported); LUSC trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg03929089 chr4:120376271 NA 0.59 6.53 0.34 2.38e-10 Axial length; LUSC cis rs72634258 0.945 rs36016881 chr1:8051241 A/G cg00042356 chr1:8021962 PARK7 0.77 9.81 0.47 3.97e-20 Inflammatory bowel disease; LUSC cis rs7267979 0.903 rs2474769 chr20:25248725 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.13 0.7 1.27e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.07 -0.36 9.22e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7639513 0.737 rs13070228 chr3:12706914 G/A cg23032965 chr3:12705835 RAF1 0.77 11.74 0.54 7.18e-27 Itch intensity from mosquito bite; LUSC trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg20587970 chr11:113659929 NA -1.27 -17.78 -0.7 3.03e-50 Hip circumference adjusted for BMI; LUSC cis rs68092024 0.731 rs793479 chr3:99488232 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 6.34 0.33 7.66e-10 Cleft lip with or without cleft palate; LUSC trans rs17685 0.712 rs869805 chr7:75688596 C/T cg19862616 chr7:65841803 NCRNA00174 1.12 19.83 0.74 2.22e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg17211192 chr8:82754475 SNX16 -0.64 -9.11 -0.45 7.56e-18 Diastolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24028381 chr8:145133668 EXOSC4 -0.54 -7.34 -0.37 1.65e-12 Bipolar disorder and schizophrenia; LUSC cis rs1371867 0.846 rs1660327 chr8:101292206 A/C cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.54e-15 Atrioventricular conduction; LUSC cis rs11098499 0.754 rs10212714 chr4:120254302 T/C cg09307838 chr4:120376055 NA 0.69 10.5 0.5 1.74e-22 Corneal astigmatism; LUSC cis rs7843479 0.965 rs733544 chr8:21835628 A/G cg17168535 chr8:21777572 XPO7 0.67 10.29 0.49 9.63e-22 Mean corpuscular volume; LUSC trans rs11098499 0.754 rs7672372 chr4:120248406 A/G cg25214090 chr10:38739885 LOC399744 0.43 6.56 0.34 2.08e-10 Corneal astigmatism; LUSC cis rs17490626 0.568 rs12413523 chr10:71211664 C/G cg14388049 chr10:71211838 TSPAN15 -0.32 -5.81 -0.3 1.47e-8 Thrombosis; LUSC cis rs7100689 0.646 rs7919380 chr10:82133380 C/T cg01528321 chr10:82214614 TSPAN14 0.86 13.08 0.58 7.25e-32 Post bronchodilator FEV1; LUSC cis rs568617 0.626 rs10896050 chr11:65577516 G/T cg19792802 chr11:65647270 CTSW 0.39 5.86 0.31 1.08e-8 Crohn's disease; LUSC cis rs12472274 0.646 rs2305171 chr2:239097140 G/A cg17459225 chr2:239074497 NA 0.58 7.89 0.4 4.27e-14 Phospholipid levels (plasma); LUSC cis rs2985684 0.779 rs12160 chr14:50091932 T/A cg04989706 chr14:50066350 PPIL5 -0.44 -5.77 -0.3 1.79e-8 Carotid intima media thickness; LUSC cis rs9287719 0.934 rs6721510 chr2:10751046 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs6977660 0.943 rs9638765 chr7:19840616 G/A cg05791153 chr7:19748676 TWISTNB 0.56 6.24 0.32 1.34e-9 Thyroid stimulating hormone; LUSC cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg02466173 chr16:30829666 NA -0.57 -10.48 -0.5 2.02e-22 Multiple myeloma; LUSC cis rs11158026 0.859 rs8019824 chr14:55365331 T/A cg04306507 chr14:55594613 LGALS3 0.31 5.84 0.3 1.24e-8 Parkinson's disease; LUSC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg14581129 chr12:53358946 NA -0.69 -9.31 -0.45 1.75e-18 Cancer (pleiotropy); LUSC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg17366294 chr4:99064904 C4orf37 0.5 8.65 0.43 2.22e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg26384229 chr12:38710491 ALG10B 0.87 14.76 0.63 2.57e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs2235649 0.663 rs6600167 chr16:1848912 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -5.96 -0.31 6.24e-9 Blood metabolite levels; LUSC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -6.47 -0.33 3.44e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg12463550 chr7:65579703 CRCP -0.49 -7.38 -0.37 1.29e-12 Aortic root size; LUSC cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 11.8 0.54 4.37e-27 Colorectal cancer; LUSC cis rs3755132 0.929 rs6431717 chr2:15740570 C/T cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.68e-12 Wilms tumor; LUSC cis rs7582180 0.629 rs11686649 chr2:100946701 T/C cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04607442 chr13:21872219 NA -0.49 -6.28 -0.32 1.05e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg22920501 chr2:26401640 FAM59B 0.83 11.99 0.55 8.76e-28 Gut microbiome composition (summer); LUSC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg11663144 chr21:46675770 NA -0.41 -7.03 -0.36 1.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7107174 0.892 rs2510033 chr11:77941771 T/G cg02023728 chr11:77925099 USP35 0.54 7.23 0.37 3.24e-12 Testicular germ cell tumor; LUSC cis rs4595586 0.679 rs35743713 chr12:39318539 C/G cg26384229 chr12:38710491 ALG10B 0.51 7.15 0.36 5.66e-12 Morning vs. evening chronotype; LUSC trans rs2797160 1.000 rs1832979 chr6:125997436 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.76 -0.35 6.17e-11 Endometrial cancer; LUSC trans rs6502050 0.835 rs8073645 chr17:80110957 C/T cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg19584341 chr11:506908 RNH1 0.47 6.45 0.33 4.03e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg26513180 chr16:89883248 FANCA 0.64 10.21 0.49 1.71e-21 Vitiligo; LUSC trans rs2797160 0.905 rs1418640 chr6:125999866 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.59 -0.34 1.71e-10 Endometrial cancer; LUSC cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg08754478 chr10:133766260 PPP2R2D -0.63 -8.22 -0.41 4.61e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg02569458 chr12:86230093 RASSF9 0.53 8.65 0.43 2.17e-16 Major depressive disorder; LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg04267008 chr7:1944627 MAD1L1 -0.54 -8.16 -0.41 6.68e-15 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.967 rs10047659 chr12:86338278 C/A cg00310523 chr12:86230176 RASSF9 0.4 7.31 0.37 1.94e-12 Major depressive disorder; LUSC cis rs12618769 0.652 rs13402379 chr2:99209314 G/A cg10123293 chr2:99228465 UNC50 0.42 6.57 0.34 1.95e-10 Bipolar disorder; LUSC cis rs9815354 0.812 rs57809229 chr3:41840162 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7072216 0.763 rs942804 chr10:100168499 C/A cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.25e-17 Metabolite levels; LUSC cis rs7843479 0.601 rs10109521 chr8:21829948 G/A cg17168535 chr8:21777572 XPO7 0.85 15.71 0.65 4.94e-42 Mean corpuscular volume; LUSC trans rs4650994 0.524 rs2811299 chr1:178586377 A/G cg05059571 chr16:84539110 KIAA1609 0.46 8.65 0.43 2.16e-16 HDL cholesterol levels;HDL cholesterol; LUSC cis rs12908161 0.920 rs12904605 chr15:85201419 T/C cg17507749 chr15:85114479 UBE2QP1 0.59 7.39 0.37 1.18e-12 Schizophrenia; LUSC cis rs240764 0.555 rs6919283 chr6:101235769 C/T cg09795085 chr6:101329169 ASCC3 0.44 6.27 0.32 1.13e-9 Neuroticism; LUSC cis rs10865541 0.902 rs13399186 chr2:3423201 G/T cg15807143 chr2:3452624 TTC15 0.32 5.69 0.3 2.72e-8 Obesity-related traits; LUSC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg11859384 chr17:80120422 CCDC57 0.36 5.69 0.3 2.71e-8 Life satisfaction; LUSC cis rs73198271 0.515 rs17629935 chr8:8619381 A/T cg01851573 chr8:8652454 MFHAS1 0.65 7.86 0.4 5.38e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2692947 0.673 rs584811 chr2:97069879 A/G cg23100626 chr2:96804247 ASTL -0.25 -6.08 -0.32 3.24e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11214589 0.651 rs11214594 chr11:113259332 G/A cg14159747 chr11:113255604 NA 0.29 7.69 0.39 1.69e-13 Neuroticism; LUSC trans rs7937682 0.602 rs11214036 chr11:111773169 C/T cg18187862 chr3:45730750 SACM1L 0.54 6.82 0.35 4.3e-11 Primary sclerosing cholangitis; LUSC cis rs11676855 1.000 rs729866 chr2:235899359 G/A cg14917874 chr2:235941519 SH3BP4 0.49 8.07 0.4 1.24e-14 Dialysis-related mortality; LUSC cis rs593982 0.925 rs3953806 chr11:65505153 C/T cg08755490 chr11:65554678 OVOL1 -1.46 -15.35 -0.64 1.35e-40 Atopic dermatitis; LUSC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg09877947 chr5:131593287 PDLIM4 0.4 6.26 0.32 1.2e-9 Breast cancer;Mosquito bite size; LUSC trans rs62458065 0.640 rs10271491 chr7:32530665 C/A cg00845942 chr12:64062724 DPY19L2 -0.59 -7.16 -0.36 5.04e-12 Metabolite levels (HVA/MHPG ratio); LUSC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16968115 chr1:27560829 WDTC1 0.43 6.43 0.33 4.43e-10 Triglycerides; LUSC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg24397884 chr7:158709396 WDR60 0.61 9.37 0.46 1.11e-18 Height; LUSC cis rs11051970 0.879 rs2728680 chr12:32583512 T/C cg24626660 chr12:32551988 NA 0.33 5.66 0.3 3.2e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3770081 1.000 rs57398459 chr2:86291326 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg16049864 chr8:95962084 TP53INP1 -0.43 -7.16 -0.36 5.32e-12 Type 2 diabetes; LUSC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg18404041 chr3:52824283 ITIH1 -0.52 -9.82 -0.47 3.77e-20 Bipolar disorder; LUSC cis rs7246967 0.611 rs12973264 chr19:22867749 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg13206674 chr6:150067644 NUP43 0.6 9.54 0.46 3.08e-19 Lung cancer; LUSC cis rs714027 0.605 rs41176 chr22:30432403 G/T cg11564601 chr22:30592435 NA -0.35 -6.01 -0.31 4.91e-9 Lymphocyte counts; LUSC cis rs57590327 0.555 rs6795133 chr3:81756267 A/G cg07356753 chr3:81810745 GBE1 -0.67 -10.51 -0.5 1.66e-22 Extraversion; LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg14092988 chr3:52407081 DNAH1 0.31 5.96 0.31 6.35e-9 Bipolar disorder; LUSC cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg08564027 chr20:61660810 NA 0.93 17.11 0.68 1.47e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs644799 0.511 rs11021302 chr11:95485768 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.69 10.21 0.49 1.81e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9517320 0.534 rs9554474 chr13:99140871 G/A cg07423050 chr13:99094983 FARP1 -0.56 -10.85 -0.51 1.04e-23 Longevity; LUSC cis rs10392 0.500 rs8118646 chr20:37600887 A/G cg27552599 chr20:37590471 DHX35 0.46 7.43 0.38 9.03e-13 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs546131 0.928 rs553789 chr11:34827579 G/A cg06937548 chr11:34938143 PDHX;APIP 0.49 6.86 0.35 3.36e-11 Lung disease severity in cystic fibrosis; LUSC cis rs11758351 0.660 rs77130538 chr6:26210723 T/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.47 0.38 7.17e-13 Gout;Renal underexcretion gout; LUSC cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg05855489 chr10:104503620 C10orf26 0.63 8.31 0.41 2.49e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg21427119 chr20:30132790 HM13 -0.37 -5.79 -0.3 1.62e-8 Mean corpuscular hemoglobin; LUSC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg02423579 chr7:2872169 GNA12 -0.38 -5.67 -0.3 3.12e-8 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03161075 chr14:51298083 NIN 0.45 6.25 0.32 1.22e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg13531842 chr10:38383804 ZNF37A -0.44 -6.77 -0.35 5.69e-11 Extrinsic epigenetic age acceleration; LUSC cis rs9527 0.590 rs4917992 chr10:104786313 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.11 0.45 7.51e-18 Arsenic metabolism; LUSC cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg08677398 chr8:58056175 NA 0.43 5.99 0.31 5.47e-9 Developmental language disorder (linguistic errors); LUSC cis rs6750047 0.932 rs11124631 chr2:38274908 A/G cg07380506 chr2:38303506 CYP1B1 -0.45 -6.47 -0.33 3.42e-10 Cutaneous malignant melanoma;Melanoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02038173 chr21:34852701 TMEM50B 0.5 7.35 0.37 1.49e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg09165964 chr15:75287851 SCAMP5 0.54 7.98 0.4 2.43e-14 Breast cancer; LUSC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg11843238 chr5:131593191 PDLIM4 0.38 5.67 0.3 3.02e-8 Breast cancer; LUSC trans rs62238980 0.614 rs76463308 chr22:32387270 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5.04e-9 Childhood ear infection; LUSC cis rs9653442 0.545 rs2009095 chr2:100765081 C/T cg07810366 chr2:100720526 AFF3 -0.43 -7.44 -0.38 8.49e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs17270561 0.609 rs1318016 chr6:25764704 A/T cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs8058578 1.000 rs7187359 chr16:30703155 G/A cg02466173 chr16:30829666 NA -0.59 -10.83 -0.51 1.28e-23 Multiple myeloma; LUSC cis rs9921192 1.000 rs2892165 chr16:4324293 A/T cg07945448 chr16:4304224 NA 0.43 6.2 0.32 1.66e-9 Prostate-specific antigen levels; LUSC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg07936489 chr17:37558343 FBXL20 0.72 9.97 0.48 1.12e-20 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg05347473 chr6:146136440 FBXO30 0.55 9.37 0.46 1.09e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs941408 0.515 rs759067 chr19:2775668 C/T cg17333051 chr19:2783644 SGTA 0.51 7.68 0.39 1.75e-13 Total cholesterol levels; LUSC cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC trans rs11098499 0.954 rs11098525 chr4:120390152 G/A cg25214090 chr10:38739885 LOC399744 0.57 8.41 0.42 1.17e-15 Corneal astigmatism; LUSC cis rs7582720 0.943 rs72928610 chr2:203838961 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1577917 0.740 rs9353327 chr6:86394066 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -7.76 -0.39 1.02e-13 Response to antipsychotic treatment; LUSC cis rs6582630 0.560 rs4882325 chr12:38510037 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.07e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs950169 0.922 rs12911223 chr15:84831671 G/A cg12863693 chr15:85201151 NMB -0.35 -7.24 -0.37 3.1e-12 Schizophrenia; LUSC cis rs11711311 1.000 rs2305545 chr3:113499733 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.6 0.34 1.6e-10 IgG glycosylation; LUSC cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC cis rs963731 0.649 rs6752850 chr2:39220655 C/T cg04010122 chr2:39346883 SOS1 -0.77 -5.68 -0.3 2.92e-8 Corticobasal degeneration; LUSC cis rs72781680 1.000 rs72796359 chr2:24160545 T/C cg20701182 chr2:24300061 SF3B14 0.77 7.73 0.39 1.25e-13 Lymphocyte counts; LUSC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.81 0.65 1.94e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg07606381 chr6:8435919 SLC35B3 0.73 12.64 0.57 3.36e-30 Motion sickness; LUSC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg02609749 chr16:89786786 C16orf7;ZNF276 0.47 7.81 0.39 7.35e-14 Vitiligo; LUSC cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg18105134 chr13:113819100 PROZ -0.67 -9.83 -0.47 3.47e-20 Platelet distribution width; LUSC trans rs208520 0.526 rs7771233 chr6:66819784 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.15 -22.94 -0.78 1.3e-70 Exhaled nitric oxide output; LUSC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg01097406 chr16:89675127 NA -0.34 -6.73 -0.35 7.18e-11 Vitiligo; LUSC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg24690094 chr11:67383802 NA 0.42 8.18 0.41 5.89e-15 Mean corpuscular volume; LUSC cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg06784218 chr1:46089804 CCDC17 0.55 10.98 0.52 3.61e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg06671706 chr8:8559999 CLDN23 0.51 6.96 0.36 1.78e-11 Obesity-related traits; LUSC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg15556689 chr8:8085844 FLJ10661 0.7 11.93 0.55 1.4e-27 Mood instability; LUSC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22590775 chr19:49891494 CCDC155 0.56 7.32 0.37 1.92e-12 Multiple sclerosis; LUSC cis rs5756931 0.503 rs2076112 chr22:38538822 A/G cg25457927 chr22:38595422 NA -0.35 -6.96 -0.36 1.84e-11 Triglycerides; LUSC cis rs2953174 0.786 rs2953177 chr2:241516616 A/G cg07929629 chr2:241523174 NA 0.53 7.99 0.4 2.21e-14 Bipolar disorder; LUSC cis rs3820928 1.000 rs12615988 chr2:227769000 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.86 -0.4 5.24e-14 Pulmonary function; LUSC cis rs4654899 1.000 rs72865329 chr1:21517567 G/A cg01072550 chr1:21505969 NA -0.56 -8.61 -0.43 2.83e-16 Superior frontal gyrus grey matter volume; LUSC cis rs1595825 0.891 rs58409972 chr2:198897061 A/T cg00982548 chr2:198649783 BOLL -0.56 -6.95 -0.36 1.93e-11 Ulcerative colitis; LUSC trans rs62055045 0.528 rs62056191 chr16:71533831 C/T cg21834679 chr15:96891026 NA -0.42 -6.58 -0.34 1.85e-10 Schizophrenia; LUSC cis rs4654899 0.865 rs12406144 chr1:21347228 A/C cg02927042 chr1:21476669 EIF4G3 -0.41 -6.42 -0.33 4.59e-10 Superior frontal gyrus grey matter volume; LUSC cis rs17270561 0.585 rs9393663 chr6:25741033 A/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.98 0.44 2.04e-17 Iron status biomarkers; LUSC cis rs10992471 0.756 rs11792342 chr9:95143668 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.2 -0.41 5.36e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1538970 0.924 rs11211117 chr1:45930246 C/T cg05343316 chr1:45956843 TESK2 0.68 9.4 0.46 9.28e-19 Platelet count; LUSC cis rs2730260 0.537 rs3793222 chr7:158863536 A/C cg02254261 chr7:158964346 NA 0.47 5.73 0.3 2.28e-8 Myopia (pathological); LUSC cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg22681709 chr2:178499509 PDE11A -0.51 -9.13 -0.45 6.86e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg04111992 chr7:158790115 NA -0.43 -6.78 -0.35 5.31e-11 Facial morphology (factor 20); LUSC cis rs28595532 0.702 rs116320061 chr4:119384600 C/T cg02775129 chr4:119771670 NA -0.79 -6.58 -0.34 1.81e-10 Cannabis dependence symptom count; LUSC cis rs11158026 0.567 rs61224609 chr14:55403208 A/G cg04306507 chr14:55594613 LGALS3 0.35 6.27 0.32 1.13e-9 Parkinson's disease; LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg10802521 chr3:52805072 NEK4 -0.56 -8.78 -0.43 8.37e-17 Bipolar disorder; LUSC cis rs2274273 0.967 rs2340931 chr14:55616937 T/G cg04306507 chr14:55594613 LGALS3 0.58 13.72 0.6 2.84e-34 Protein biomarker; LUSC cis rs1478897 0.575 rs12679960 chr8:11430990 C/T cg21175976 chr8:11421337 BLK 0.4 6.63 0.34 1.35e-10 Systemic lupus erythematosus; LUSC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg21724239 chr8:58056113 NA 0.8 8.6 0.43 3.04e-16 Developmental language disorder (linguistic errors); LUSC cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -8.27 -0.41 3.31e-15 Axial length; LUSC cis rs1858037 0.867 rs67817304 chr2:65574116 C/T cg08085232 chr2:65598271 SPRED2 -0.4 -5.92 -0.31 7.88e-9 Rheumatoid arthritis; LUSC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg06877462 chr1:205807181 PM20D1 0.5 8.99 0.44 1.94e-17 Menarche (age at onset); LUSC cis rs10489202 0.632 rs202268 chr1:167927339 T/C cg24449463 chr1:168025552 DCAF6 -0.73 -12.19 -0.55 1.6e-28 Schizophrenia; LUSC cis rs6087771 0.747 rs6058261 chr20:30235470 C/A cg13852791 chr20:30311386 BCL2L1 0.86 12.03 0.55 6.28e-28 Subcortical brain region volumes;Putamen volume; LUSC cis rs9326248 0.581 rs7120706 chr11:116830087 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.59 -9.12 -0.45 7.26e-18 Blood protein levels; LUSC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg06494592 chr3:125709126 NA -0.52 -5.91 -0.31 8.54e-9 Blood pressure (smoking interaction); LUSC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg09650180 chr20:62225654 GMEB2 -0.66 -9.69 -0.47 1.03e-19 Glioblastoma; LUSC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg13206674 chr6:150067644 NUP43 0.5 7.53 0.38 4.76e-13 Lung cancer; LUSC cis rs6977660 1.000 rs34367208 chr7:19818811 T/G cg05791153 chr7:19748676 TWISTNB 0.54 5.94 0.31 7.08e-9 Thyroid stimulating hormone; LUSC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg02896835 chr1:92012615 NA -0.64 -11.56 -0.53 3.22e-26 Breast cancer; LUSC cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg06627628 chr2:24431161 ITSN2 -0.59 -7.24 -0.37 3.06e-12 Lymphocyte counts; LUSC trans rs2262909 0.962 rs1526884 chr19:22303651 A/G cg17074339 chr11:11642133 GALNTL4 0.43 6.6 0.34 1.61e-10 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg12386194 chr3:101231763 SENP7 0.54 7.71 0.39 1.48e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs6502050 0.835 rs7406220 chr17:80077850 T/C cg07393940 chr7:158741817 NA -0.37 -6.56 -0.34 2.1e-10 Life satisfaction; LUSC cis rs459571 0.920 rs417142 chr9:136891370 G/T cg13789015 chr9:136890014 NCRNA00094 0.7 12.67 0.57 2.67e-30 Platelet distribution width; LUSC cis rs2948294 0.588 rs12544596 chr8:8116346 A/T cg08975724 chr8:8085496 FLJ10661 0.55 7.21 0.37 3.79e-12 Red cell distribution width; LUSC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg07716408 chr11:68623521 NA -0.32 -6.13 -0.32 2.48e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11039100 0.607 rs34841036 chr11:5782464 A/G cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg06238570 chr21:40685208 BRWD1 -0.62 -10.39 -0.49 4.41e-22 Cognitive function; LUSC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.44 5.86 0.31 1.09e-8 Tonsillectomy; LUSC cis rs7589728 1.000 rs6720809 chr2:88528943 T/C cg04511125 chr2:88470314 THNSL2 0.65 6.15 0.32 2.2e-9 Plasma clusterin levels; LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg11645453 chr3:52864694 ITIH4 0.35 8.38 0.42 1.53e-15 Bipolar disorder; LUSC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.4 5.7 0.3 2.61e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg06740227 chr12:86229804 RASSF9 0.42 6.61 0.34 1.53e-10 Major depressive disorder; LUSC cis rs4363385 0.588 rs6698361 chr1:153023184 T/G cg00922841 chr1:152955080 SPRR1A -0.36 -5.94 -0.31 7.13e-9 Inflammatory skin disease; LUSC cis rs983392 0.679 rs611418 chr11:60011013 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.16 0.32 2.12e-9 Alzheimer's disease (late onset); LUSC cis rs238295 0.805 rs6116855 chr20:5555317 A/G cg15842884 chr20:5591925 RP5-1022P6.2 -0.44 -5.95 -0.31 6.84e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs7084921 0.608 rs11596211 chr10:101840119 T/A cg11888571 chr10:102027403 CWF19L1 -0.43 -5.84 -0.3 1.23e-8 Bone mineral density; LUSC cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.51 -0.38 5.61e-13 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.38 0.37 1.23e-12 Bipolar disorder; LUSC cis rs7267979 0.903 rs6115109 chr20:25239667 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.38 0.67 1.16e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs34734847 1.000 rs2948149 chr12:121162854 T/G cg21892295 chr12:121157589 UNC119B -0.48 -8.59 -0.43 3.49e-16 Mean corpuscular volume; LUSC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg17628894 chr11:804452 LRDD 0.48 11.21 0.52 5.55e-25 Breast cancer; LUSC trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg15704280 chr7:45808275 SEPT13 0.73 8.22 0.41 4.64e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs4805834 0.719 rs12151363 chr19:33309030 A/T cg00891608 chr19:33463040 C19orf40;CCDC123 -0.56 -5.68 -0.3 2.87e-8 Creatinine levels; LUSC cis rs672059 1.000 rs575474 chr1:183158599 T/C ch.1.3577855R chr1:183094577 LAMC1 0.54 7.98 0.4 2.42e-14 Hypertriglyceridemia; LUSC cis rs7202877 0.611 rs4888395 chr16:75413715 T/G cg04384234 chr16:75411784 CFDP1 -0.66 -9.59 -0.46 2.2e-19 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg14004847 chr7:1930337 MAD1L1 -0.56 -8.75 -0.43 1.09e-16 Bipolar disorder and schizophrenia; LUSC trans rs1325195 0.920 rs2636276 chr1:179111060 A/G cg11624085 chr17:8464688 MYH10 -0.42 -6.78 -0.35 5.57e-11 IgE grass sensitization; LUSC cis rs7618501 1.000 rs34451146 chr3:49813013 C/T cg13072238 chr3:49761600 GMPPB 0.4 6.63 0.34 1.36e-10 Intelligence (multi-trait analysis); LUSC cis rs4629710 0.592 rs4424112 chr6:131563788 C/T cg12606694 chr6:131520996 AKAP7 0.63 9.57 0.46 2.46e-19 Multiple myeloma (IgH translocation); LUSC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg25456477 chr12:86230367 RASSF9 0.43 7.75 0.39 1.15e-13 Major depressive disorder; LUSC trans rs853679 0.517 rs9393888 chr6:28059217 G/C cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.31e-9 Depression; LUSC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg06238570 chr21:40685208 BRWD1 -0.61 -10.05 -0.48 6.19e-21 Cognitive function; LUSC cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg04756594 chr16:24857601 SLC5A11 -0.37 -6.14 -0.32 2.36e-9 Intelligence (multi-trait analysis); LUSC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg05373962 chr22:49881684 NA -0.45 -10.68 -0.5 4.3e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11098499 0.863 rs3775845 chr4:120432447 T/C cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.72e-25 Corneal astigmatism; LUSC cis rs34779708 0.966 rs11010129 chr10:35510822 T/C cg04310649 chr10:35416472 CREM -0.41 -6.31 -0.33 8.91e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1538970 0.962 rs9429076 chr1:45819489 A/G cg05343316 chr1:45956843 TESK2 0.44 5.65 0.3 3.44e-8 Platelet count; LUSC cis rs672059 1.000 rs563026 chr1:183161037 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.55 -8.21 -0.41 4.94e-15 Hypertriglyceridemia; LUSC cis rs11785400 0.793 rs1056012 chr8:143740167 A/G cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.02 0.4 1.81e-14 Parkinson's disease; LUSC cis rs11997175 0.546 rs4545051 chr8:33608863 T/C ch.8.33884649F chr8:33765107 NA 0.49 7.78 0.39 8.96e-14 Body mass index; LUSC trans rs17685 0.884 rs3823882 chr7:75631913 T/C cg19862616 chr7:65841803 NCRNA00174 -1.0 -15.22 -0.64 4.31e-40 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg03128945 chr5:622914 CEP72 -0.44 -6.51 -0.34 2.77e-10 Obesity-related traits; LUSC cis rs6964587 1.000 rs60147309 chr7:91736098 C/G cg22117172 chr7:91764530 CYP51A1 0.32 5.73 0.3 2.25e-8 Breast cancer; LUSC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg19717773 chr7:2847554 GNA12 -0.39 -6.14 -0.32 2.28e-9 Height; LUSC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg07936489 chr17:37558343 FBXL20 -0.71 -9.99 -0.48 9.76e-21 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11890956 chr21:40555474 PSMG1 -0.86 -14.99 -0.63 3.39e-39 Cognitive function; LUSC cis rs17401966 0.965 rs12751375 chr1:10291874 C/G cg19773385 chr1:10388646 KIF1B -0.54 -8.31 -0.41 2.44e-15 Hepatocellular carcinoma; LUSC cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg27129171 chr3:47204927 SETD2 -0.66 -10.55 -0.5 1.22e-22 Colorectal cancer; LUSC cis rs7180079 1.000 rs1388216 chr15:64500148 A/G cg08069370 chr15:64387884 SNX1 -0.54 -5.85 -0.3 1.17e-8 Monocyte count; LUSC cis rs752010 1.000 rs2077172 chr1:42093340 A/G cg06885757 chr1:42089581 HIVEP3 0.46 9.49 0.46 4.56e-19 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs1371867 0.846 rs1660312 chr8:101330634 C/G cg06002616 chr8:101225028 SPAG1 -0.48 -7.81 -0.39 7.6e-14 Atrioventricular conduction; LUSC cis rs765787 0.530 rs28815867 chr15:45526805 G/C cg25801113 chr15:45476975 SHF 0.33 6.9 0.35 2.62e-11 Uric acid levels; LUSC trans rs941408 0.515 rs1005556 chr19:2778543 G/T cg22153745 chr1:153894579 GATAD2B -0.5 -6.97 -0.36 1.73e-11 Total cholesterol levels; LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.96 0.61 3.35e-35 Platelet count; LUSC cis rs2729354 0.817 rs2250673 chr11:57268170 T/C cg24343310 chr11:57249947 NA 0.44 8.5 0.42 6.52e-16 Blood protein levels; LUSC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.63 -0.69 1.23e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs3093024 0.595 rs4412174 chr6:167476066 A/G cg25258033 chr6:167368657 RNASET2 0.45 6.87 0.35 3.17e-11 Rheumatoid arthritis; LUSC cis rs796364 0.616 rs769955 chr2:200692595 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.97 0.31 5.91e-9 Schizophrenia; LUSC cis rs7786808 0.530 rs7785656 chr7:158184164 C/G cg01191920 chr7:158217561 PTPRN2 -0.41 -7.96 -0.4 2.75e-14 Obesity-related traits; LUSC cis rs1577917 0.958 rs13213899 chr6:86473140 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.95 -0.44 2.42e-17 Response to antipsychotic treatment; LUSC cis rs4253772 0.575 rs9615364 chr22:46797503 G/A cg00784671 chr22:46762841 CELSR1 -0.5 -5.74 -0.3 2.15e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9303401 0.659 rs7216648 chr17:56790858 C/T cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs9837602 0.938 rs28503408 chr3:99794842 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.32 0.33 8.6e-10 Breast cancer; LUSC cis rs17270561 0.609 rs3778272 chr6:25767661 G/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.32 0.37 1.81e-12 Iron status biomarkers; LUSC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg09658497 chr7:2847517 GNA12 -0.32 -5.74 -0.3 2.13e-8 Height; LUSC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg20684491 chr1:25596433 NA 0.37 5.92 0.31 8.2e-9 Erythrocyte sedimentation rate; LUSC trans rs2514895 0.660 rs7109796 chr11:127111252 T/C cg22738642 chr12:43137977 NA 0.5 6.26 0.32 1.18e-9 IgG glycosylation; LUSC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg13206674 chr6:150067644 NUP43 0.59 9.45 0.46 5.92e-19 Lung cancer; LUSC cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg01528321 chr10:82214614 TSPAN14 0.62 9.08 0.45 9.41e-18 Post bronchodilator FEV1; LUSC trans rs7939886 0.920 rs1905069 chr11:55887135 T/C cg03929089 chr4:120376271 NA 0.75 6.11 0.32 2.77e-9 Myopia (pathological); LUSC trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.48 6.51 0.34 2.68e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs12618769 0.652 rs3203856 chr2:99226021 C/T cg10123293 chr2:99228465 UNC50 0.47 7.71 0.39 1.48e-13 Bipolar disorder; LUSC trans rs62103177 0.565 rs473119 chr18:77849459 T/G cg14227996 chr4:17616232 MED28 -0.55 -6.15 -0.32 2.26e-9 Opioid sensitivity; LUSC cis rs240764 0.817 rs12193960 chr6:101150326 C/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.15 -0.32 2.16e-9 Neuroticism; LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg08088566 chr11:430123 ANO9 0.67 7.42 0.38 1e-12 Body mass index; LUSC cis rs11105298 0.891 rs11105313 chr12:89923376 A/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.52 7.48 0.38 6.46e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs559928 0.606 rs76653616 chr11:63936139 T/G cg24687543 chr11:63912206 MACROD1 0.47 5.82 0.3 1.4e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC trans rs208520 0.789 rs9351549 chr6:66871851 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -16.16 -0.66 8.05e-44 Exhaled nitric oxide output; LUSC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11890956 chr21:40555474 PSMG1 0.97 16.93 0.68 7.27e-47 Cognitive function; LUSC cis rs4474465 0.736 rs11237541 chr11:78261703 T/C cg27205649 chr11:78285834 NARS2 0.53 6.45 0.33 4.02e-10 Alzheimer's disease (survival time); LUSC trans rs17266958 0.892 rs118057986 chr9:83278885 G/C cg01905489 chr1:26616534 UBXN11 -0.61 -6.27 -0.32 1.15e-9 Preschool internalizing problems; LUSC cis rs62400317 0.859 rs10456549 chr6:45225761 C/T cg18551225 chr6:44695536 NA -0.44 -7.35 -0.37 1.55e-12 Total body bone mineral density; LUSC cis rs868036 0.645 rs4776972 chr15:68083436 A/C cg24579218 chr15:68104479 NA -0.39 -6.28 -0.33 1.04e-9 Restless legs syndrome; LUSC cis rs10887741 0.690 rs12781358 chr10:89444367 C/T cg24243914 chr10:89418206 PAPSS2 0.31 6.09 0.32 3.09e-9 Exercise (leisure time); LUSC cis rs1670533 0.932 rs13108207 chr4:1054218 C/T cg27284194 chr4:1044797 NA 0.59 8.87 0.44 4.34e-17 Recombination rate (females); LUSC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg15445000 chr17:37608096 MED1 0.36 6.48 0.33 3.2e-10 Glomerular filtration rate (creatinine); LUSC cis rs1865760 0.566 rs2858993 chr6:26087856 T/A cg17691542 chr6:26056736 HIST1H1C 0.54 8.08 0.4 1.23e-14 Height; LUSC cis rs354225 0.544 rs12713267 chr2:54805607 T/C cg26097391 chr2:54893211 SPTBN1 0.46 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs950776 0.506 rs12915366 chr15:78831753 G/A cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs243505 0.767 rs243518 chr7:148425028 A/G cg09806900 chr7:148480153 CUL1 -0.52 -6.86 -0.35 3.42e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7584330 0.554 rs6705908 chr2:238433965 A/G cg16989719 chr2:238392110 NA -0.36 -5.68 -0.3 3e-8 Prostate cancer; LUSC cis rs6464929 0.955 rs7781312 chr7:148724236 A/T cg23583168 chr7:148888333 NA 0.46 5.77 0.3 1.83e-8 Pediatric bone mineral content (hip); LUSC cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8078723 1.000 rs8078723 chr17:38166879 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.82 -0.35 4.31e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg13560548 chr3:10150139 C3orf24 -0.53 -7.84 -0.39 6.21e-14 Alzheimer's disease; LUSC cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.43 -0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11890956 chr21:40555474 PSMG1 -0.91 -16.16 -0.66 8.34e-44 Cognitive function; LUSC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg20891558 chr2:74357851 NA 0.79 14.27 0.62 2.04e-36 Gestational age at birth (maternal effect); LUSC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg23422044 chr7:1970798 MAD1L1 -0.67 -7.59 -0.38 3.19e-13 Bipolar disorder; LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.98 -0.31 5.81e-9 Platelet count; LUSC trans rs2729385 1.000 rs2729385 chr11:57262993 C/T cg10193671 chr17:79846205 THOC4 -0.43 -5.95 -0.31 6.68e-9 Interleukin-18 levels; LUSC cis rs8060686 0.641 rs76053508 chr16:68243054 A/T cg04539111 chr16:67997858 SLC12A4 -0.43 -5.68 -0.3 2.96e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs6598955 0.694 rs4659416 chr1:26580937 T/G cg04990556 chr1:26633338 UBXN11 -0.8 -14.83 -0.63 1.4e-38 Obesity-related traits; LUSC cis rs3768617 0.528 rs4651144 chr1:183097421 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 10.95 0.51 4.95e-24 Fuchs's corneal dystrophy; LUSC cis rs2843152 0.524 rs1496555 chr1:2234251 A/G cg07425568 chr1:2236650 SKI 0.51 6.47 0.33 3.48e-10 Coronary artery disease; LUSC cis rs3740393 0.562 rs2297450 chr10:104503174 T/C cg05855489 chr10:104503620 C10orf26 0.56 5.74 0.3 2.07e-8 Microalbuminuria; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg01802117 chr1:53393560 SCP2 -0.38 -6.17 -0.32 1.93e-9 Monocyte count; LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.23 0.52 4.66e-25 Menopause (age at onset); LUSC cis rs2439831 1.000 rs690436 chr15:43761205 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs861020 0.883 rs680331 chr1:209959872 G/A cg09163369 chr1:210001066 C1orf107 0.51 5.88 0.31 9.74e-9 Orofacial clefts; LUSC cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.66 -0.3 3.24e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs79911532 0.551 rs41301427 chr7:75614557 G/A cg03592824 chr7:75666768 STYXL1 0.69 6.79 0.35 5.09e-11 Mononucleosis; LUSC trans rs57046232 0.552 rs6133306 chr20:6333294 T/G cg21095983 chr6:86352623 SYNCRIP 0.47 7.02 0.36 1.26e-11 Colorectal cancer; LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg22166914 chr1:53195759 ZYG11B 0.5 7.98 0.4 2.38e-14 Monocyte count; LUSC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg22437258 chr11:111473054 SIK2 0.53 7.53 0.38 4.93e-13 Primary sclerosing cholangitis; LUSC cis rs1878931 0.697 rs10048148 chr16:3417450 C/G cg00484396 chr16:3507460 NAT15 -0.36 -5.91 -0.31 8.22e-9 Body mass index (adult); LUSC cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg10811474 chr19:8428787 ANGPTL4 -0.39 -5.97 -0.31 6.03e-9 HDL cholesterol; LUSC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg15556689 chr8:8085844 FLJ10661 -0.67 -10.7 -0.51 3.53e-23 Mood instability; LUSC cis rs4622329 0.593 rs7960780 chr12:102309768 C/T cg23541617 chr12:102225335 GNPTAB 0.26 5.82 0.3 1.36e-8 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg05340658 chr4:99064831 C4orf37 0.68 11.61 0.54 2.11e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9443189 0.570 rs9341532 chr6:76403674 A/G cg01950844 chr6:76311363 SENP6 0.68 6.84 0.35 3.85e-11 Prostate cancer; LUSC trans rs61931739 0.782 rs3903201 chr12:34248275 G/A cg13010199 chr12:38710504 ALG10B 0.39 6.2 0.32 1.64e-9 Morning vs. evening chronotype; LUSC cis rs78456975 1.000 rs13397299 chr2:1564222 A/C cg12573674 chr2:1569213 NA -0.55 -6.16 -0.32 2.15e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.35 -7.43 -0.38 9.36e-13 Hemoglobin concentration; LUSC cis rs997295 0.618 rs3784698 chr15:68007582 G/C cg27219399 chr15:67835830 MAP2K5 -0.36 -5.78 -0.3 1.68e-8 Motion sickness; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg06145435 chr7:1022769 CYP2W1 0.31 6.34 0.33 7.57e-10 Longevity;Endometriosis; LUSC trans rs10435719 0.834 rs6985792 chr8:11795335 T/C cg15556689 chr8:8085844 FLJ10661 0.56 8.43 0.42 1.05e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.83 -0.47 3.27e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9399137 0.507 rs7754722 chr6:135260303 T/C cg24558204 chr6:135376177 HBS1L -0.64 -9.25 -0.45 2.7e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs17095355 0.605 rs2274978 chr10:111631665 C/G cg00817464 chr10:111662876 XPNPEP1 0.55 6.47 0.33 3.53e-10 Biliary atresia; LUSC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs10782582 0.593 rs12126155 chr1:76131555 C/G cg10523679 chr1:76189770 ACADM -0.49 -7.07 -0.36 9.34e-12 Daytime sleep phenotypes; LUSC cis rs6582630 0.560 rs12315134 chr12:38419857 T/A cg13010199 chr12:38710504 ALG10B -0.44 -6.55 -0.34 2.12e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2880765 0.835 rs7168860 chr15:86037030 G/A cg13263323 chr15:86062960 AKAP13 -0.35 -5.66 -0.3 3.34e-8 Coronary artery disease; LUSC cis rs3768617 0.528 rs10737242 chr1:183098249 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg12311346 chr5:56204834 C5orf35 0.61 9.29 0.45 2.09e-18 Coronary artery disease; LUSC cis rs9814567 1.000 rs1498718 chr3:134205920 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.59 -0.6 8.31e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4253772 0.530 rs9615349 chr22:46732418 T/G cg24881330 chr22:46731750 TRMU 0.78 6.56 0.34 2.07e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs7772486 0.846 rs1854901 chr6:146325685 T/C cg23711669 chr6:146136114 FBXO30 0.84 15.12 0.64 9.9e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg06481639 chr22:41940642 POLR3H 0.49 5.67 0.3 3.04e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9650315 0.610 rs11988740 chr8:57205976 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.24 0.37 3.02e-12 Height; LUSC cis rs62408225 1.000 rs11757155 chr6:90941240 C/T cg06866423 chr6:90926672 BACH2 0.4 5.78 0.3 1.74e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.01 0.4 1.97e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs3126085 0.935 rs7550106 chr1:152197202 C/T cg03465714 chr1:152285911 FLG 0.42 6.2 0.32 1.7e-9 Atopic dermatitis; LUSC cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg16482183 chr6:26056742 HIST1H1C 0.51 7.48 0.38 6.48e-13 Height; LUSC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg18230493 chr5:56204884 C5orf35 -0.92 -13.68 -0.6 3.94e-34 Initial pursuit acceleration; LUSC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg02428538 chr16:24856791 SLC5A11 -0.52 -5.82 -0.3 1.38e-8 Intelligence (multi-trait analysis); LUSC cis rs12908161 0.959 rs34784022 chr15:85231906 T/C cg11189052 chr15:85197271 WDR73 0.48 5.93 0.31 7.56e-9 Schizophrenia; LUSC cis rs6912958 0.558 rs9444530 chr6:88343318 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.41 5.91 0.31 8.56e-9 Monocyte percentage of white cells; LUSC cis rs3772130 0.962 rs11706783 chr3:121534322 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.22 0.49 1.66e-21 Cognitive performance; LUSC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs2760061 0.624 rs10442629 chr1:228191070 T/A cg18477163 chr1:228402036 OBSCN 0.51 8.59 0.43 3.44e-16 Diastolic blood pressure; LUSC trans rs11241130 0.669 rs255891 chr5:111003610 T/A cg24626752 chr13:88328274 SLITRK5 0.73 6.31 0.33 8.65e-10 Obesity-related traits; LUSC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg23978390 chr7:1156363 C7orf50 0.42 6.06 0.31 3.74e-9 Longevity;Endometriosis; LUSC cis rs11031096 0.502 rs4910598 chr11:4101368 C/T cg08557956 chr11:4115526 RRM1 -0.47 -5.96 -0.31 6.47e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4499344 0.730 rs369859 chr19:33104305 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC trans rs6084875 0.840 rs6052833 chr20:4731142 C/G cg26257163 chr5:25190441 NA -0.36 -6.13 -0.32 2.44e-9 Systemic lupus erythematosus; LUSC cis rs11122272 0.735 rs973254 chr1:231521149 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.3 -0.49 8.89e-22 Hemoglobin concentration; LUSC cis rs9948 0.655 rs78424221 chr2:97410399 A/G cg01990225 chr2:97406019 LMAN2L -1.08 -7.25 -0.37 3.01e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg23034840 chr1:205782522 SLC41A1 0.68 9.88 0.48 2.39e-20 Menarche (age at onset); LUSC cis rs2486288 0.656 rs12911861 chr15:45566718 T/C cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.58 -0.5 9.73e-23 Glomerular filtration rate; LUSC cis rs9303401 0.659 rs62083525 chr17:56658088 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC trans rs2797160 0.967 rs1739355 chr6:126018114 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.87 0.35 3.16e-11 Endometrial cancer; LUSC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.87e-12 Blood metabolite levels; LUSC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg08280861 chr8:58055591 NA 0.58 6.31 0.33 8.78e-10 Developmental language disorder (linguistic errors); LUSC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.36 0.62 9.07e-37 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2455799 0.533 rs2470550 chr3:15743721 C/T cg09340198 chr3:15902540 ANKRD28 -0.33 -5.98 -0.31 5.71e-9 Mean platelet volume; LUSC cis rs7927771 0.524 rs11039392 chr11:47798753 A/G cg20307385 chr11:47447363 PSMC3 0.44 6.47 0.33 3.54e-10 Subjective well-being; LUSC cis rs1577917 1.000 rs36096931 chr6:86693134 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.45 -0.42 9.25e-16 Response to antipsychotic treatment; LUSC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg06481639 chr22:41940642 POLR3H -0.53 -6.08 -0.32 3.19e-9 Vitiligo; LUSC cis rs7089973 0.604 rs7919649 chr10:116609576 T/C cg23260525 chr10:116636907 FAM160B1 0.44 9.33 0.45 1.49e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg09998033 chr7:158218633 PTPRN2 0.54 8.68 0.43 1.82e-16 Obesity-related traits; LUSC cis rs9303401 0.527 rs12939313 chr17:56755616 A/T cg25039879 chr17:56429692 SUPT4H1 0.65 8.19 0.41 5.71e-15 Cognitive test performance; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.32 0.77 3.6e-68 Prudent dietary pattern; LUSC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg05717871 chr11:638507 DRD4 -0.35 -5.96 -0.31 6.35e-9 Systemic lupus erythematosus; LUSC cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg15839431 chr19:19639596 YJEFN3 0.44 5.99 0.31 5.56e-9 Tonsillectomy; LUSC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg18876405 chr7:65276391 NA 0.68 12.14 0.55 2.35e-28 Aortic root size; LUSC cis rs9300255 0.569 rs1727320 chr12:123700476 T/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC trans rs6601327 0.641 rs7462070 chr8:9571364 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.41 -0.33 5.07e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs6087990 0.735 rs6058883 chr20:31365719 C/T cg13636640 chr20:31349939 DNMT3B -0.93 -19.79 -0.73 3.14e-58 Ulcerative colitis; LUSC cis rs6424115 0.830 rs2229585 chr1:24200921 T/C cg15997130 chr1:24165203 NA 0.52 8.58 0.43 3.6e-16 Immature fraction of reticulocytes; LUSC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg11247378 chr22:39784982 NA -0.63 -12.41 -0.56 2.37e-29 Intelligence (multi-trait analysis); LUSC trans rs1994135 0.654 rs1384591 chr12:33734170 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.32 0.41 2.28e-15 Resting heart rate; LUSC cis rs1577917 0.958 rs6900436 chr6:86506288 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.78 -0.43 8.55e-17 Response to antipsychotic treatment; LUSC cis rs6121246 0.909 rs6060793 chr20:30288830 T/G cg18721089 chr20:30220636 NA -0.34 -5.94 -0.31 7.26e-9 Mean corpuscular hemoglobin; LUSC cis rs28785552 0.589 rs7257371 chr19:53243910 A/G cg10871876 chr19:53194124 ZNF83 0.54 7.81 0.39 7.48e-14 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg02269571 chr22:50332266 NA -0.59 -8.94 -0.44 2.7e-17 Schizophrenia; LUSC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg10523679 chr1:76189770 ACADM -0.84 -12.32 -0.56 5.17e-29 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg06145435 chr7:1022769 CYP2W1 0.31 6.64 0.34 1.28e-10 Longevity;Endometriosis; LUSC cis rs2439831 0.681 rs28578454 chr15:43603032 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.03 13.51 0.59 1.78e-33 Lung cancer in ever smokers; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg07092213 chr7:1199455 ZFAND2A -0.57 -8.97 -0.44 2.21e-17 Longevity;Endometriosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23743186 chr22:39152048 UNC84B -0.4 -6.06 -0.31 3.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg18876405 chr7:65276391 NA 0.57 9.24 0.45 2.86e-18 Aortic root size; LUSC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg09085632 chr11:111637200 PPP2R1B -1.04 -16.58 -0.67 1.75e-45 Primary sclerosing cholangitis; LUSC cis rs11155671 0.530 rs4458704 chr6:150232879 A/C cg09699651 chr6:150184138 LRP11 0.45 6.94 0.36 2.05e-11 Testicular germ cell tumor; LUSC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg19678392 chr7:94953810 PON1 -0.36 -5.68 -0.3 2.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg11812906 chr14:75593930 NEK9 0.66 11.33 0.53 2.04e-25 Height; LUSC cis rs8032315 0.862 rs7166599 chr15:91403674 A/G cg04510874 chr15:91427884 FES 0.33 6.5 0.34 2.84e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs6598955 0.671 rs11247910 chr1:26645666 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.31 -0.41 2.44e-15 Obesity-related traits; LUSC cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.1 -0.41 1.03e-14 Neuroticism; LUSC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg05973401 chr12:123451056 ABCB9 0.52 7.01 0.36 1.32e-11 Neutrophil percentage of white cells; LUSC cis rs4409675 0.619 rs12070173 chr1:28231955 G/C cg23691781 chr1:28212827 C1orf38 0.31 7.48 0.38 6.53e-13 Corneal astigmatism; LUSC cis rs10791097 0.694 rs61910787 chr11:130744473 G/A cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.54e-10 Menopause (age at onset); LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg16405210 chr4:1374714 KIAA1530 -0.51 -7.64 -0.39 2.32e-13 Obesity-related traits; LUSC cis rs3126085 0.935 rs11204941 chr1:152203343 A/G cg03465714 chr1:152285911 FLG -0.4 -5.67 -0.3 3.07e-8 Atopic dermatitis; LUSC cis rs6547741 0.874 rs58737572 chr2:27852118 A/C cg27432699 chr2:27873401 GPN1 0.83 15.77 0.65 2.86e-42 Oral cavity cancer; LUSC trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg12564285 chr5:131593104 PDLIM4 -0.42 -7.64 -0.39 2.33e-13 Breast cancer; LUSC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.74 10.07 0.48 5.09e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4654899 0.931 rs6661116 chr1:21337155 C/G cg01072550 chr1:21505969 NA -0.55 -8.41 -0.42 1.23e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7605827 0.930 rs10179754 chr2:15541214 C/T cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg08470875 chr2:26401718 FAM59B -0.69 -9.43 -0.46 7.31e-19 Gut microbiome composition (summer); LUSC cis rs1507153 0.548 rs236853 chr6:79339466 T/C cg05283184 chr6:79620031 NA 0.39 7.08 0.36 8.51e-12 Sjögren's syndrome; LUSC cis rs4660306 0.677 rs781061 chr1:45932887 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.41 5.66 0.3 3.22e-8 Homocysteine levels; LUSC cis rs7520050 0.807 rs3013594 chr1:46138000 T/C cg06784218 chr1:46089804 CCDC17 0.29 5.81 0.3 1.43e-8 Red blood cell count;Reticulocyte count; LUSC cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs10761482 0.566 rs10159663 chr10:62208417 A/G cg18175470 chr10:62150864 ANK3 0.48 6.68 0.34 9.79e-11 Schizophrenia; LUSC trans rs2797160 1.000 rs1739367 chr6:126004720 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.16e-10 Endometrial cancer; LUSC cis rs9291683 0.527 rs3822241 chr4:10094931 G/A cg00071950 chr4:10020882 SLC2A9 -0.62 -10.31 -0.49 8.26e-22 Bone mineral density; LUSC cis rs11122272 0.735 rs2437147 chr1:231516756 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs1595825 0.891 rs73056811 chr2:198766642 T/C cg00982548 chr2:198649783 BOLL -0.56 -7.0 -0.36 1.41e-11 Ulcerative colitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08619651 chr7:127807832 NA -0.38 -5.95 -0.31 6.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2262909 0.962 rs2017521 chr19:22126138 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -6.19 -0.32 1.8e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6121246 0.559 rs6058462 chr20:30367674 C/T cg13852791 chr20:30311386 BCL2L1 0.93 14.15 0.61 6.1e-36 Mean corpuscular hemoglobin; LUSC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs3862030 0.839 rs12570859 chr10:104257226 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.62 -9.65 -0.47 1.37e-19 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17370395 chr8:135725535 ZFAT 0.45 5.96 0.31 6.29e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11672220 chr5:177302789 LOC728554 0.73 6.57 0.34 1.92e-10 Cognitive performance; LUSC cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg21665744 chr7:39171113 POU6F2 0.44 6.64 0.34 1.3e-10 IgG glycosylation; LUSC cis rs1007190 0.881 rs9915066 chr17:42962166 C/T cg15406952 chr17:42872593 NA 0.55 5.68 0.3 2.97e-8 DNA methylation (variation); LUSC cis rs7712401 0.601 rs154500 chr5:122211991 T/G cg19077854 chr5:122220652 SNX24 0.41 9.22 0.45 3.48e-18 Mean platelet volume; LUSC trans rs750134 0.901 rs17040894 chr12:109092717 C/T cg23338993 chr2:234600423 UGT1A10;UGT1A6;UGT1A9;UGT1A7;UGT1A8 0.48 6.13 0.32 2.51e-9 Low high density lipoprotein cholesterol levels; LUSC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg12463550 chr7:65579703 CRCP -0.55 -8.31 -0.41 2.49e-15 Aortic root size; LUSC trans rs7567288 0.636 rs12989658 chr2:134462988 C/T cg12381416 chr3:14359266 NA 0.56 6.26 0.32 1.17e-9 Height; LUSC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg04546413 chr19:29218101 NA 0.71 11.42 0.53 1.03e-25 Methadone dose in opioid dependence; LUSC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.68 6.93 0.35 2.14e-11 Initial pursuit acceleration; LUSC cis rs6500395 0.962 rs55782524 chr16:48557493 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.11 0.32 2.77e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg27535305 chr1:53392650 SCP2 0.37 6.77 0.35 5.83e-11 Monocyte count; LUSC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg05754148 chr16:3507555 NAT15 -0.53 -7.82 -0.39 6.81e-14 Tuberculosis; LUSC cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg15309053 chr8:964076 NA -0.38 -7.76 -0.39 1.01e-13 Schizophrenia; LUSC cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs7084921 0.608 rs12780514 chr10:101865884 T/C cg02250046 chr10:101825185 CPN1 -0.34 -6.28 -0.33 1.03e-9 Bone mineral density; LUSC cis rs6733011 0.500 rs2280142 chr2:99434872 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.26 -0.32 1.16e-9 Bipolar disorder; LUSC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg20476274 chr7:133979776 SLC35B4 0.8 13.85 0.6 8.46e-35 Mean platelet volume; LUSC cis rs5769707 0.605 rs9616702 chr22:50025938 A/G cg20744362 chr22:50050164 C22orf34 0.39 7.38 0.37 1.29e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6961069 0.585 rs6969989 chr7:80254410 A/G cg04458919 chr7:80252533 CD36 -0.38 -6.68 -0.34 9.79e-11 Platelet count; LUSC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg08439880 chr3:133502540 NA 0.31 5.71 0.3 2.44e-8 Iron status biomarkers; LUSC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg16339924 chr4:17578868 LAP3 0.58 9.05 0.44 1.18e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg08888203 chr3:10149979 C3orf24 0.63 9.06 0.44 1.09e-17 Alzheimer's disease; LUSC cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.52 -0.5 1.56e-22 Monocyte percentage of white cells; LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg03790207 chr6:42947109 PEX6 -0.43 -6.43 -0.33 4.4e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2304069 0.954 rs9324638 chr5:149400718 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.77 -9.13 -0.45 6.74e-18 HIV-1 control; LUSC cis rs11098499 0.863 rs7669520 chr4:120515278 T/C cg09307838 chr4:120376055 NA 0.73 10.54 0.5 1.3e-22 Corneal astigmatism; LUSC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg09365446 chr1:150670422 GOLPH3L -0.42 -6.33 -0.33 7.9e-10 Tonsillectomy; LUSC cis rs2625529 0.652 rs11634608 chr15:72255718 A/G cg16672083 chr15:72433130 SENP8 0.48 8.01 0.4 1.87e-14 Red blood cell count; LUSC cis rs2806561 0.704 rs674386 chr1:23521835 G/A cg12483005 chr1:23474871 LUZP1 0.45 6.92 0.35 2.28e-11 Height; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.79 0.39 8.3e-14 Lymphocyte counts; LUSC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg10802521 chr3:52805072 NEK4 -0.41 -6.43 -0.33 4.3e-10 Electroencephalogram traits; LUSC cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg08917208 chr2:24149416 ATAD2B 0.53 5.97 0.31 6e-9 Lymphocyte counts; LUSC cis rs7267979 1.000 rs6107045 chr20:25441936 G/A cg03522245 chr20:25566470 NINL 0.35 5.66 0.3 3.26e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6582630 0.502 rs1589390 chr12:38416139 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.32 -0.41 2.2e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs4285028 0.948 rs73855480 chr3:121676646 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.63 -0.47 1.55e-19 Multiple sclerosis; LUSC cis rs9311676 0.656 rs55913214 chr3:58388026 A/G cg26110898 chr3:58419937 PDHB 0.4 6.49 0.33 3.05e-10 Systemic lupus erythematosus; LUSC cis rs877282 0.891 rs11599917 chr10:762288 G/A cg17470449 chr10:769945 NA 0.5 7.12 0.36 6.5e-12 Uric acid levels; LUSC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg21361702 chr7:150065534 REPIN1 0.47 6.34 0.33 7.6e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7666738 0.515 rs13118898 chr4:98792893 T/A cg05340658 chr4:99064831 C4orf37 0.58 8.63 0.43 2.47e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs73198271 0.700 rs10103282 chr8:8650757 T/G cg15556689 chr8:8085844 FLJ10661 -0.43 -5.65 -0.3 3.38e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12618769 0.597 rs17504774 chr2:99135627 A/G cg10123293 chr2:99228465 UNC50 -0.46 -7.55 -0.38 4.08e-13 Bipolar disorder; LUSC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg17971929 chr21:40555470 PSMG1 0.79 13.68 0.6 3.87e-34 Cognitive function; LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.18 0.61 4.74e-36 Platelet count; LUSC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg20573242 chr4:122745356 CCNA2 0.64 9.03 0.44 1.36e-17 Type 2 diabetes; LUSC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.94 -0.4 3.13e-14 Mean platelet volume; LUSC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg05872129 chr22:39784769 NA -0.6 -10.76 -0.51 2.21e-23 Intelligence (multi-trait analysis); LUSC cis rs3806843 1.000 rs10477033 chr5:140169603 G/C cg19875535 chr5:140030758 IK 0.49 8.04 0.4 1.57e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs9318086 0.578 rs2077709 chr13:24476073 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.43 -6.46 -0.33 3.76e-10 Myopia (pathological); LUSC trans rs4729127 1.000 rs74856107 chr7:94017640 C/T cg20086523 chr13:52378287 DHRS12 0.62 6.65 0.34 1.23e-10 Intelligence; LUSC cis rs4919087 0.926 rs2861875 chr10:98990139 C/G cg25902810 chr10:99078978 FRAT1 -0.45 -6.67 -0.34 1.08e-10 Monocyte count; LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.46 0.53 7.26e-26 Menopause (age at onset); LUSC cis rs11166629 1.000 rs4909331 chr8:135644540 T/C cg27224718 chr8:135614730 ZFAT 0.64 10.62 0.5 7.01e-23 Smoking quantity; LUSC trans rs4332037 1.000 rs62442899 chr7:1948454 C/T cg11693508 chr17:37793320 STARD3 0.65 7.95 0.4 2.97e-14 Bipolar disorder; LUSC cis rs911119 0.913 rs13043266 chr20:23588127 C/T cg16589663 chr20:23618590 CST3 0.61 7.23 0.37 3.41e-12 Chronic kidney disease; LUSC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.01 0.44 1.56e-17 Height; LUSC cis rs1322512 0.874 rs2038618 chr6:152971286 C/G cg27316956 chr6:152958899 SYNE1 -0.37 -6.32 -0.33 8.18e-10 Tonometry; LUSC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg24399712 chr22:39784796 NA -0.64 -11.84 -0.54 2.99e-27 Intelligence (multi-trait analysis); LUSC cis rs7336332 0.598 rs74183666 chr13:28007765 A/T cg22138327 chr13:27999177 GTF3A 0.82 9.95 0.48 1.34e-20 Weight; LUSC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg15556689 chr8:8085844 FLJ10661 0.58 8.71 0.43 1.44e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs798554 0.671 rs1182195 chr7:2868730 A/G cg02423579 chr7:2872169 GNA12 -0.4 -6.0 -0.31 5.22e-9 Height; LUSC trans rs7939886 0.841 rs11231800 chr11:55770930 A/G cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs73129298 0.551 rs6095728 chr20:48599960 C/T cg25655593 chr20:48599521 SNAI1 0.6 6.48 0.33 3.34e-10 Inflammatory skin disease; LUSC cis rs7267979 0.718 rs2983489 chr20:25244120 C/A cg08601574 chr20:25228251 PYGB 0.38 5.81 0.3 1.47e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1559088 0.948 rs10406916 chr19:33590093 G/A cg03563238 chr19:33554763 RHPN2 -0.41 -6.56 -0.34 2.09e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7582180 0.629 rs12989897 chr2:100940998 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg22676075 chr6:135203613 NA 0.56 8.75 0.43 1.06e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg11058730 chr11:34937778 PDHX;APIP 0.69 11.23 0.52 4.65e-25 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7255 0.538 rs2289081 chr2:20881840 G/C cg09074113 chr2:20870087 GDF7 -0.31 -5.81 -0.3 1.45e-8 Barrett's esophagus or Esophageal adenocarcinoma;Esophageal adenocarcinoma; LUSC cis rs7681440 0.647 rs4522832 chr4:90819391 A/C cg01966878 chr4:90757139 SNCA -0.35 -5.68 -0.3 2.89e-8 Dementia with Lewy bodies; LUSC trans rs4940203 0.625 rs17682262 chr18:50227374 C/T cg14465628 chr9:98125437 NA 0.3 6.09 0.32 3.12e-9 Obesity-related traits; LUSC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg21285383 chr16:89894308 SPIRE2 0.33 7.09 0.36 8.26e-12 Vitiligo; LUSC cis rs55665837 1.000 rs11023216 chr11:14437153 G/A cg05501817 chr11:14380813 RRAS2 -0.41 -6.71 -0.34 8.1e-11 Vitamin D levels; LUSC cis rs2197308 0.765 rs2387436 chr12:37935337 C/T cg13010199 chr12:38710504 ALG10B -0.6 -9.31 -0.45 1.8e-18 Morning vs. evening chronotype; LUSC cis rs561341 0.609 rs7214626 chr17:30190989 G/A cg00745463 chr17:30367425 LRRC37B 0.63 7.58 0.38 3.37e-13 Hip circumference adjusted for BMI; LUSC cis rs11155671 0.530 rs7764376 chr6:150210344 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC cis rs9399135 0.904 rs4895438 chr6:135317665 G/T cg24558204 chr6:135376177 HBS1L 0.59 9.2 0.45 3.94e-18 Red blood cell count; LUSC cis rs208520 1.000 rs12193077 chr6:66989548 C/T cg07460842 chr6:66804631 NA 0.92 12.09 0.55 3.84e-28 Exhaled nitric oxide output; LUSC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg13939156 chr17:80058883 NA 0.33 6.46 0.33 3.79e-10 Life satisfaction; LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg15147215 chr3:52552868 STAB1 0.31 6.02 0.31 4.52e-9 Bipolar disorder; LUSC cis rs4499344 0.730 rs34270210 chr19:33103945 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg00484396 chr16:3507460 NAT15 0.49 7.28 0.37 2.34e-12 Body mass index (adult); LUSC cis rs17125944 0.686 rs77650471 chr14:53364307 C/T cg00686598 chr14:53173677 PSMC6 0.87 7.49 0.38 6.02e-13 Alzheimer's disease (late onset); LUSC cis rs701145 0.938 rs701133 chr3:154070312 A/G cg17054900 chr3:154042577 DHX36 0.79 8.03 0.4 1.73e-14 Coronary artery disease; LUSC cis rs7267979 0.727 rs4815431 chr20:25532405 T/C cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.06e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4474465 1.000 rs10899525 chr11:78201454 T/G cg27205649 chr11:78285834 NARS2 -0.51 -5.91 -0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs4776059 1.000 rs2288271 chr15:52886466 A/G cg25063058 chr15:52860530 ARPP19 0.47 6.35 0.33 7.21e-10 Schizophrenia; LUSC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg06740227 chr12:86229804 RASSF9 0.39 6.02 0.31 4.51e-9 Major depressive disorder; LUSC cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg19628046 chr18:33552617 C18orf21 0.52 6.26 0.32 1.15e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6429082 0.755 rs291371 chr1:235693105 C/G cg26050004 chr1:235667680 B3GALNT2 0.57 8.12 0.41 8.82e-15 Adiposity; LUSC cis rs7100689 0.622 rs10749595 chr10:82172975 C/T cg00277334 chr10:82204260 NA -0.52 -6.92 -0.35 2.27e-11 Post bronchodilator FEV1; LUSC cis rs4948102 0.595 rs10255049 chr7:56121304 G/A cg17215666 chr7:56131930 SUMF2 0.44 5.96 0.31 6.26e-9 Plasma homocysteine levels (post-methionine load test); LUSC cis rs9369695 0.883 rs9473128 chr6:47505010 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.64 0.3 3.58e-8 Reticulocyte count; LUSC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23248424 chr5:179741104 GFPT2 -0.54 -8.36 -0.42 1.69e-15 Height; LUSC cis rs17826219 0.500 rs61685770 chr17:29085713 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Body mass index; LUSC trans rs6582630 0.502 rs1607876 chr12:38355750 T/C cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.28e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs41271473 0.607 rs10916361 chr1:228859971 A/T cg16512390 chr1:228756714 NA 0.51 7.28 0.37 2.4e-12 Chronic lymphocytic leukemia; LUSC cis rs11039131 0.629 rs67871383 chr11:47335838 T/C cg20307385 chr11:47447363 PSMC3 -0.54 -6.87 -0.35 3.12e-11 Schizophrenia; LUSC cis rs6163 0.588 rs11191392 chr10:104526951 C/A cg05855489 chr10:104503620 C10orf26 0.93 18.91 0.72 1.02e-54 Waist circumference;Hip circumference; LUSC cis rs1801251 0.963 rs7562712 chr2:233606580 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.34 2.87e-10 Coronary artery disease; LUSC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 11.06 0.52 1.91e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9650315 0.866 rs34205064 chr8:57199171 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.13 0.36 6.25e-12 Height; LUSC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg19812747 chr11:111475976 SIK2 -0.57 -8.44 -0.42 9.47e-16 Primary sclerosing cholangitis; LUSC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg00031303 chr3:195681400 NA 0.7 10.09 0.48 4.37e-21 Pancreatic cancer; LUSC cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs7954584 0.567 rs11612028 chr12:122387872 C/G cg22618164 chr12:122356400 WDR66 0.62 9.35 0.46 1.27e-18 Mean corpuscular volume; LUSC cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg21385522 chr1:16154831 NA 0.52 7.75 0.39 1.15e-13 Systolic blood pressure; LUSC trans rs208520 0.690 rs12198297 chr6:66714665 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.83 0.68 1.9e-46 Exhaled nitric oxide output; LUSC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.51 6.47 0.33 3.48e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg27170947 chr2:26402098 FAM59B 0.6 8.1 0.41 1.03e-14 Gut microbiome composition (summer); LUSC cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg03146154 chr1:46216737 IPP -0.5 -7.23 -0.37 3.3e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10782582 0.593 rs11589276 chr1:76105545 G/A cg22875332 chr1:76189707 ACADM -0.43 -6.46 -0.33 3.8e-10 Daytime sleep phenotypes; LUSC cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg13010199 chr12:38710504 ALG10B 0.64 9.86 0.47 2.64e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs61931739 0.534 rs10844774 chr12:34166764 C/T cg06521331 chr12:34319734 NA -0.45 -7.37 -0.37 1.36e-12 Morning vs. evening chronotype; LUSC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg01416388 chr22:39784598 NA -0.49 -7.94 -0.4 3.14e-14 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.52 0.69 3.21e-49 Chronic sinus infection; LUSC cis rs2204008 0.659 rs4002655 chr12:38169881 T/G cg13010199 chr12:38710504 ALG10B 0.68 10.62 0.5 6.57e-23 Bladder cancer; LUSC trans rs4729127 0.908 rs55746023 chr7:94006138 G/A cg14660007 chr13:78271894 SLAIN1 0.51 6.54 0.34 2.35e-10 Intelligence; LUSC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg18876405 chr7:65276391 NA 0.55 8.59 0.43 3.48e-16 Aortic root size; LUSC cis rs3087591 0.960 rs2953012 chr17:29496486 A/G cg24425628 chr17:29625626 OMG;NF1 0.54 7.98 0.4 2.34e-14 Hip circumference; LUSC cis rs2273669 0.504 rs74991574 chr6:109482270 A/G cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC cis rs1775715 0.737 rs2151047 chr10:32102110 G/A cg04359828 chr10:32216031 ARHGAP12 0.41 6.95 0.36 1.95e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs62408225 0.722 rs10944481 chr6:90917314 A/G cg06866423 chr6:90926672 BACH2 -0.39 -6.22 -0.32 1.45e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs561341 0.830 rs7218801 chr17:30217778 A/G cg20587970 chr11:113659929 NA 1.1 13.16 0.58 3.68e-32 Hip circumference adjusted for BMI; LUSC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg07274523 chr3:49395745 GPX1 0.64 9.89 0.48 2.19e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg23978390 chr7:1156363 C7orf50 0.44 6.29 0.33 1.02e-9 Longevity;Endometriosis; LUSC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg22029157 chr1:209979665 IRF6 0.71 8.84 0.44 5.78e-17 Cleft lip with or without cleft palate; LUSC cis rs2742417 0.603 rs2742453 chr3:45765858 G/A cg10512202 chr3:45649293 LIMD1 0.36 5.89 0.31 9.25e-9 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs9329221 0.537 rs6995859 chr8:9975709 T/A cg21775007 chr8:11205619 TDH 0.43 6.04 0.31 4.1e-9 Neuroticism; LUSC cis rs9393777 0.778 rs35608615 chr6:27040402 G/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.5 -5.83 -0.3 1.34e-8 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg27494647 chr7:150038898 RARRES2 0.52 7.88 0.4 4.61e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs6987853 0.933 rs2923434 chr8:42422307 A/G cg09913449 chr8:42400586 C8orf40 0.48 8.14 0.41 7.92e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg11062466 chr8:58055876 NA 0.66 8.49 0.42 7.08e-16 Developmental language disorder (linguistic errors); LUSC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg06022373 chr22:39101656 GTPBP1 0.78 12.08 0.55 3.89e-28 Menopause (age at onset); LUSC cis rs13315871 1.000 rs11710058 chr3:58383048 G/A cg20936604 chr3:58311152 NA -0.65 -6.04 -0.31 4.06e-9 Cholesterol, total; LUSC cis rs7824557 0.701 rs4568582 chr8:11160495 A/T cg21293242 chr8:11204541 TDH 0.31 5.88 0.31 9.79e-9 Retinal vascular caliber; LUSC trans rs3806843 1.000 rs3756340 chr5:140180451 T/G cg25815440 chr2:42134162 NA -0.26 -6.02 -0.31 4.51e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs10207628 0.698 rs7566991 chr2:127880933 T/A cg06223080 chr2:127868745 NA 0.38 6.58 0.34 1.79e-10 Psychosis and Alzheimer's disease; LUSC cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg01420254 chr6:26195488 NA 0.62 7.06 0.36 9.63e-12 Gout;Renal underexcretion gout; LUSC cis rs12681288 0.550 rs4272405 chr8:959014 C/G cg04851639 chr8:1020857 NA -0.35 -7.0 -0.36 1.4e-11 Schizophrenia; LUSC cis rs12681287 0.608 rs13273338 chr8:87453361 T/G cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs6542838 0.611 rs7423519 chr2:99518319 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.51 -6.84 -0.35 3.83e-11 Fear of minor pain; LUSC cis rs898097 0.690 rs3785520 chr17:80895745 T/C cg15664640 chr17:80829946 TBCD 0.64 9.79 0.47 4.55e-20 Breast cancer; LUSC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg12310025 chr6:25882481 NA -0.6 -10.03 -0.48 7.27e-21 Intelligence (multi-trait analysis); LUSC cis rs909002 0.772 rs12740754 chr1:32083273 G/C cg01639898 chr1:32083012 HCRTR1 0.31 7.59 0.38 3.33e-13 Intelligence (multi-trait analysis); LUSC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg17340268 chr14:105411764 AHNAK2 -0.38 -6.29 -0.33 9.99e-10 Rheumatoid arthritis; LUSC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg25025879 chr12:53359317 NA -0.58 -9.04 -0.44 1.29e-17 Cancer (pleiotropy); LUSC cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg17892150 chr10:133769511 PPP2R2D -0.68 -9.47 -0.46 5.35e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs7567288 0.636 rs10496707 chr2:134458931 A/G cg12381416 chr3:14359266 NA 0.57 6.29 0.33 1.01e-9 Height; LUSC trans rs7824557 0.564 rs34964435 chr8:11230206 G/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.09 -0.4 1.15e-14 Retinal vascular caliber; LUSC trans rs8030485 0.571 rs10775219 chr15:79443894 G/A cg16586880 chr8:140854244 TRAPPC9 -0.37 -6.0 -0.31 5.24e-9 Left ventricle wall thickness; LUSC cis rs9814567 0.964 rs12492930 chr3:134222722 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.79 -0.6 1.45e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.45e-17 Motion sickness; LUSC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg08048268 chr3:133502702 NA -0.46 -8.83 -0.43 6.15e-17 Iron status biomarkers; LUSC cis rs1018836 0.923 rs7812970 chr8:91541229 G/A cg16814680 chr8:91681699 NA -0.74 -12.34 -0.56 4.47e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs314370 0.855 rs76181418 chr7:100494960 G/T cg08558340 chr7:100472263 SRRT 0.51 6.27 0.32 1.11e-9 Resting heart rate; LUSC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg03289416 chr15:75166202 SCAMP2 0.38 5.77 0.3 1.85e-8 Caffeine consumption; LUSC cis rs9549260 0.753 rs9532578 chr13:41236407 G/A cg21288729 chr13:41239152 FOXO1 0.56 6.2 0.32 1.69e-9 Red blood cell count; LUSC cis rs6722750 0.716 rs2422115 chr2:64414815 A/G cg22352474 chr2:64371530 PELI1 -0.5 -7.39 -0.37 1.17e-12 Neuroticism; LUSC cis rs8072100 0.713 rs8075058 chr17:45482857 A/G cg08085267 chr17:45401833 C17orf57 -0.5 -7.25 -0.37 2.97e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg15744005 chr10:104629667 AS3MT -0.33 -6.76 -0.35 6.2e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10504073 0.565 rs12056536 chr8:49890132 C/T cg00325661 chr8:49890786 NA -0.7 -11.21 -0.52 5.52e-25 Blood metabolite ratios; LUSC cis rs7523273 0.586 rs2724359 chr1:207935706 A/G cg22525895 chr1:207977042 MIR29B2 0.41 6.61 0.34 1.5e-10 Schizophrenia; LUSC cis rs4363385 0.747 rs1338180 chr1:152981404 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.71 -0.39 1.48e-13 Inflammatory skin disease; LUSC cis rs6426558 0.537 rs2102634 chr1:227324308 T/C cg10327440 chr1:227177885 CDC42BPA -0.55 -7.41 -0.38 1.02e-12 Neutrophil percentage of white cells; LUSC cis rs10875746 0.951 rs10875747 chr12:48525861 A/G cg13454099 chr12:49076203 C12orf41 -0.52 -6.16 -0.32 2.11e-9 Longevity (90 years and older); LUSC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg24531977 chr5:56204891 C5orf35 -0.93 -14.52 -0.62 2.24e-37 Initial pursuit acceleration; LUSC cis rs10493773 1.000 rs2274738 chr1:86119898 A/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.51 -0.46 3.82e-19 Urate levels in overweight individuals; LUSC cis rs9487051 0.834 rs436880 chr6:109553069 C/T cg01475377 chr6:109611718 NA -0.35 -5.76 -0.3 1.87e-8 Reticulocyte fraction of red cells; LUSC cis rs2692947 0.832 rs2579550 chr2:96741944 G/A cg22654517 chr2:96458247 NA 0.33 6.15 0.32 2.27e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg11764359 chr7:65958608 NA 0.56 7.11 0.36 6.93e-12 Aortic root size; LUSC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg20243544 chr17:37824526 PNMT 0.39 6.02 0.31 4.54e-9 Self-reported allergy; LUSC cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg00071950 chr4:10020882 SLC2A9 0.53 8.65 0.43 2.22e-16 Bone mineral density; LUSC cis rs11893307 0.507 rs1465305 chr2:191585392 C/G cg11845111 chr2:191398756 TMEM194B -0.42 -5.7 -0.3 2.6e-8 Mean platelet volume; LUSC cis rs11098499 0.542 rs7677836 chr4:120310638 T/A cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs2274273 0.805 rs11628437 chr14:55775468 G/A cg04306507 chr14:55594613 LGALS3 0.54 12.05 0.55 5.23e-28 Protein biomarker; LUSC cis rs2760061 0.583 rs708124 chr1:228220771 A/T cg02753203 chr1:228287806 NA 0.99 20.61 0.75 1.82e-61 Diastolic blood pressure; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.29 0.56 6.76e-29 Prudent dietary pattern; LUSC trans rs236907 0.859 rs6681322 chr1:171773871 A/G cg13482142 chr2:234261155 NA -0.5 -6.12 -0.32 2.56e-9 Mean platelet volume; LUSC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg14773178 chr5:1868261 NA 0.31 5.65 0.3 3.4e-8 Cardiovascular disease risk factors; LUSC cis rs9326248 0.530 rs562179 chr11:116805204 T/C cg26566898 chr11:117069891 TAGLN 0.44 6.01 0.31 4.9e-9 Blood protein levels; LUSC cis rs6430585 0.793 rs11684545 chr2:136539122 G/T cg07169764 chr2:136633963 MCM6 -0.59 -7.91 -0.4 3.86e-14 Corneal structure; LUSC trans rs853679 0.607 rs200489 chr6:27798257 T/C cg06606381 chr12:133084897 FBRSL1 -0.79 -7.75 -0.39 1.13e-13 Depression; LUSC cis rs7824557 0.628 rs11250129 chr8:11202154 G/A cg21293242 chr8:11204541 TDH 0.31 5.82 0.3 1.37e-8 Retinal vascular caliber; LUSC cis rs9399135 0.967 rs7766189 chr6:135353851 A/C cg24558204 chr6:135376177 HBS1L 0.59 9.24 0.45 2.88e-18 Red blood cell count; LUSC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg18252515 chr7:66147081 NA -1.23 -13.29 -0.59 1.17e-32 Diabetic kidney disease; LUSC trans rs7613875 0.580 rs6808044 chr3:50136165 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.52 -8.21 -0.41 4.98e-15 Body mass index; LUSC cis rs7909074 0.865 rs10900123 chr10:45376574 C/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.47 -0.42 7.95e-16 Mean corpuscular volume; LUSC cis rs4776059 0.550 rs55895733 chr15:52952159 T/G cg22715398 chr15:52968154 KIAA1370 0.68 7.61 0.38 2.82e-13 Schizophrenia; LUSC cis rs7246657 0.524 rs10411251 chr19:37428755 C/T cg23950597 chr19:37808831 NA -0.51 -5.7 -0.3 2.65e-8 Coronary artery calcification; LUSC cis rs10203711 1.000 rs11682137 chr2:239588939 G/A cg14580085 chr2:239553406 NA 0.42 7.02 0.36 1.21e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4332037 0.826 rs4721188 chr7:1953615 G/A cg02421172 chr7:1938701 MAD1L1 -0.44 -6.04 -0.31 4.22e-9 Bipolar disorder; LUSC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg03576123 chr11:487126 PTDSS2 -1.04 -10.97 -0.51 4.14e-24 Body mass index; LUSC cis rs9473147 0.516 rs7749271 chr6:47485002 T/C cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs8078723 0.668 rs4239225 chr17:38127112 G/A cg17467752 chr17:38218738 THRA 0.52 7.71 0.39 1.44e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs11992162 0.551 rs59191504 chr8:11785081 A/G cg14343924 chr8:8086146 FLJ10661 -0.46 -6.31 -0.33 8.7e-10 Monocyte count; LUSC cis rs6964587 0.839 rs62466809 chr7:91472801 A/G cg17063962 chr7:91808500 NA 0.56 8.57 0.42 3.87e-16 Breast cancer; LUSC cis rs981844 1.000 rs55702511 chr4:154665978 A/C cg14289246 chr4:154710475 SFRP2 0.47 5.74 0.3 2.15e-8 Response to statins (LDL cholesterol change); LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg06873352 chr17:61820015 STRADA 0.7 12.71 0.57 1.91e-30 Prudent dietary pattern; LUSC cis rs2898290 0.694 rs2248909 chr8:11392093 A/C cg27411982 chr8:10470053 RP1L1 -0.44 -7.07 -0.36 9.28e-12 Systolic blood pressure; LUSC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg26597838 chr10:835615 NA 0.76 9.03 0.44 1.37e-17 Eosinophil percentage of granulocytes; LUSC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg09703963 chr11:616879 IRF7;MUPCDH -0.47 -7.22 -0.37 3.59e-12 Systemic lupus erythematosus; LUSC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg16060761 chr17:80687452 NA 0.47 7.61 0.38 2.9e-13 Breast cancer; LUSC cis rs1113500 0.933 rs1419003 chr1:108616955 A/C cg06207961 chr1:108661230 NA 0.42 7.8 0.39 8.21e-14 Growth-regulated protein alpha levels; LUSC cis rs864537 0.646 rs1773542 chr1:167432949 T/C cg22356347 chr1:167427500 CD247 -0.34 -8.19 -0.41 5.49e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC trans rs11123259 0.794 rs35894488 chr2:115696981 C/A cg00844339 chr9:138873417 NA 0.3 6.01 0.31 4.79e-9 Gut microbiome composition (winter); LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC cis rs9902453 0.967 rs8082175 chr17:28430303 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.43 0.42 1.04e-15 Coffee consumption (cups per day); LUSC cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 18.1 0.7 1.66e-51 Chronic sinus infection; LUSC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.21 0.32 1.54e-9 Menopause (age at onset); LUSC cis rs56091001 0.528 rs9616387 chr22:50313219 G/A cg02269571 chr22:50332266 NA -0.84 -9.8 -0.47 4.29e-20 Acne (severe); LUSC cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.5 -0.46 4.36e-19 Schizophrenia; LUSC cis rs1712517 0.873 rs7913461 chr10:105001325 A/G cg05636881 chr10:105038444 INA 0.4 6.55 0.34 2.18e-10 Migraine; LUSC cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg00530320 chr1:46809349 NSUN4 0.56 8.7 0.43 1.57e-16 Menopause (age at onset); LUSC cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg24558204 chr6:135376177 HBS1L 0.67 10.32 0.49 7.41e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs12620999 0.941 rs2875690 chr2:237977737 G/A cg23555395 chr2:238036564 NA 0.45 7.62 0.38 2.59e-13 Systemic lupus erythematosus; LUSC cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg21573476 chr21:45109991 RRP1B -0.41 -6.77 -0.35 5.75e-11 Mean corpuscular volume; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg04267008 chr7:1944627 MAD1L1 -0.53 -8.12 -0.41 8.88e-15 Bipolar disorder and schizophrenia; LUSC trans rs10805346 0.558 rs12506562 chr4:10106954 G/T cg26043149 chr18:55253948 FECH 0.45 7.12 0.36 6.72e-12 Urate levels in overweight individuals;Urate levels in obese individuals; LUSC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.89 0.44 3.75e-17 Schizophrenia; LUSC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg04111992 chr7:158790115 NA 0.45 7.15 0.36 5.51e-12 Facial morphology (factor 20); LUSC cis rs9916302 0.752 rs676882 chr17:37433424 A/T cg07936489 chr17:37558343 FBXL20 0.78 9.51 0.46 3.94e-19 Glomerular filtration rate (creatinine); LUSC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg22437258 chr11:111473054 SIK2 0.54 7.65 0.39 2.16e-13 Primary sclerosing cholangitis; LUSC trans rs61931739 0.517 rs4104182 chr12:34081343 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.28 0.53 3.23e-25 Morning vs. evening chronotype; LUSC cis rs1215050 0.740 rs700740 chr4:98976003 A/C cg05340658 chr4:99064831 C4orf37 -0.47 -7.45 -0.38 8.22e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg25456477 chr12:86230367 RASSF9 0.33 5.8 0.3 1.55e-8 Major depressive disorder; LUSC cis rs7917772 0.582 rs4285804 chr10:104386309 T/A cg05855489 chr10:104503620 C10orf26 0.46 7.07 0.36 9.11e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11644478 chr21:40555479 PSMG1 -0.74 -13.13 -0.58 4.71e-32 Cognitive function; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.01 0.31 4.91e-9 Menopause (age at onset); LUSC cis rs983392 0.678 rs1562990 chr11:60023087 C/A cg24026212 chr11:59952134 MS4A6A 0.37 6.39 0.33 5.63e-10 Alzheimer's disease (late onset); LUSC cis rs1559088 0.895 rs7259582 chr19:33593979 A/G cg17764715 chr19:33622953 WDR88 0.6 8.29 0.41 2.72e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg08008072 chr16:1524255 CLCN7 -0.68 -14.84 -0.63 1.28e-38 Bone mineral density; LUSC cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg24450063 chr1:156163899 SLC25A44 1.07 17.26 0.69 3.57e-48 Testicular germ cell tumor; LUSC cis rs17661538 0.504 rs11591227 chr10:18436307 A/G cg03634479 chr10:18430412 CACNB2 0.69 6.61 0.34 1.53e-10 Response to antipsychotic treatment; LUSC cis rs500891 0.574 rs34783351 chr6:84139030 G/T cg08257003 chr6:84140564 ME1 0.37 9.1 0.45 8.48e-18 Platelet-derived growth factor BB levels; LUSC cis rs79349575 0.783 rs62075839 chr17:46996434 G/C cg22482690 chr17:47019901 SNF8 0.4 7.47 0.38 7.15e-13 Type 2 diabetes; LUSC cis rs7772486 0.875 rs2748502 chr6:146298239 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.64 0.43 2.35e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 1.000 rs74704838 chr2:24158270 C/A cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.71 10.64 0.5 5.59e-23 Monocyte percentage of white cells; LUSC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg00071950 chr4:10020882 SLC2A9 -0.52 -7.99 -0.4 2.25e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7520050 0.778 rs3014216 chr1:46035760 A/T cg24296786 chr1:45957014 TESK2 -0.4 -5.66 -0.3 3.25e-8 Red blood cell count;Reticulocyte count; LUSC cis rs72781680 0.898 rs116113042 chr2:23960194 G/T cg20701182 chr2:24300061 SF3B14 0.55 5.85 0.3 1.2e-8 Lymphocyte counts; LUSC cis rs508618 0.731 rs576462 chr1:231544607 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -6.8 -0.35 4.72e-11 Red blood cell count; LUSC cis rs7617773 0.780 rs34589064 chr3:48339549 G/A cg11946769 chr3:48343235 NME6 0.88 14.29 0.62 1.69e-36 Coronary artery disease; LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg18405360 chr17:1531863 SLC43A2 0.47 6.01 0.31 4.98e-9 Thyroid stimulating hormone; LUSC cis rs10911232 0.507 rs4442336 chr1:182982538 T/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Hypertriglyceridemia; LUSC cis rs1395 1.000 rs1275528 chr2:27430781 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.39 -6.47 -0.33 3.47e-10 Blood metabolite levels; LUSC cis rs2307022 0.566 rs2035869 chr16:68386754 A/G cg02226672 chr16:68398533 SMPD3 0.32 6.09 0.32 3.06e-9 Body mass index; LUSC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg05340658 chr4:99064831 C4orf37 -0.62 -10.62 -0.5 7.04e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 1.000 rs2011503 chr19:19443986 C/T cg11244672 chr19:19639970 YJEFN3 -0.55 -6.85 -0.35 3.47e-11 Bipolar disorder; LUSC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg18512352 chr11:47633146 NA -0.43 -9.06 -0.44 1.09e-17 Subjective well-being; LUSC trans rs8072100 0.581 rs4267364 chr17:45781264 A/G cg03886242 chr7:26192032 NFE2L3 -0.41 -6.47 -0.33 3.47e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs57046232 0.552 rs6054184 chr20:6354592 A/G cg21095983 chr6:86352623 SYNCRIP 0.49 7.25 0.37 2.95e-12 Colorectal cancer; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg26338869 chr17:61819248 STRADA 0.42 6.07 0.32 3.43e-9 Prudent dietary pattern; LUSC cis rs1983891 0.955 rs4714487 chr6:41547312 T/C cg15051332 chr6:41514432 FOXP4 0.41 5.97 0.31 5.95e-9 Prostate cancer; LUSC trans rs1493916 1.000 rs1493916 chr18:31392577 T/G cg13755796 chr4:20253514 NA -0.43 -6.67 -0.34 1.07e-10 Life satisfaction; LUSC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg12963246 chr6:28129442 ZNF389 0.39 6.22 0.32 1.5e-9 Parkinson's disease; LUSC cis rs9399135 0.967 rs952674 chr6:135349157 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.14 0.45 6.29e-18 Red blood cell count; LUSC cis rs7149337 1.000 rs4261445 chr14:51723540 G/A cg23942311 chr14:51606299 NA 0.48 10.75 0.51 2.41e-23 Cancer; LUSC cis rs983392 0.679 rs1026254 chr11:60030457 A/G cg24026212 chr11:59952134 MS4A6A 0.35 5.97 0.31 6.09e-9 Alzheimer's disease (late onset); LUSC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs7605827 0.930 rs3828465 chr2:15535497 A/T cg19274914 chr2:15703543 NA 0.46 9.16 0.45 5.5e-18 Educational attainment (years of education); LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.07 0.77 3.19e-67 Prudent dietary pattern; LUSC cis rs1865760 0.566 rs9358902 chr6:26058570 C/G cg17691542 chr6:26056736 HIST1H1C 0.54 8.11 0.41 9.42e-15 Height; LUSC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg25554036 chr4:6271136 WFS1 0.6 12.13 0.55 2.59e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs929596 0.564 rs2741030 chr2:234536152 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.31 -0.33 8.94e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg11247378 chr22:39784982 NA -0.64 -13.09 -0.58 6.72e-32 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg11766577 chr21:47581405 C21orf56 -0.56 -8.64 -0.43 2.29e-16 Testicular germ cell tumor; LUSC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.67 0.34 1.06e-10 Lung cancer; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.45 6.04 0.31 4.13e-9 Renal function-related traits (BUN); LUSC cis rs9394438 0.628 rs4714079 chr6:37544439 C/T cg00985040 chr6:37553208 NA -0.4 -8.95 -0.44 2.42e-17 IgG glycosylation; LUSC cis rs7582720 1.000 rs72936323 chr2:204050474 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.38 0.42 1.54e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs977987 0.806 rs12917651 chr16:75466696 G/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.4e-11 Dupuytren's disease; LUSC cis rs7123876 0.541 rs61895574 chr11:72347988 A/T cg03878208 chr11:72483293 STARD10 0.53 5.97 0.31 6.13e-9 Body mass index; LUSC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg15017067 chr4:17643749 FAM184B 0.36 6.03 0.31 4.27e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs870825 1.000 rs870821 chr4:185587377 T/C cg04058563 chr4:185651563 MLF1IP 0.82 11.2 0.52 6.13e-25 Blood protein levels; LUSC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.69 -0.39 1.63e-13 Aortic root size; LUSC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.69e-20 Gut microbiome composition (summer); LUSC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.77 7.65 0.39 2.1e-13 Initial pursuit acceleration; LUSC cis rs35883536 0.609 rs10783142 chr1:101043902 C/G cg06223162 chr1:101003688 GPR88 -0.48 -9.12 -0.45 7.32e-18 Monocyte count; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg27588902 chr6:42928151 GNMT -0.3 -6.55 -0.34 2.12e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7833790 0.777 rs7815272 chr8:82691809 T/G cg27398817 chr8:82754497 SNX16 -0.65 -8.11 -0.41 9.85e-15 Diastolic blood pressure; LUSC cis rs1506636 1.000 rs1911145 chr7:123363658 A/G cg03229431 chr7:123269106 ASB15 -0.65 -10.57 -0.5 9.99e-23 Plateletcrit;Platelet count; LUSC cis rs3106136 0.527 rs10030586 chr4:95150805 A/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.41 -0.42 1.25e-15 Capecitabine sensitivity; LUSC cis rs4654899 0.627 rs667071 chr1:21045726 T/C cg01072550 chr1:21505969 NA -0.41 -6.28 -0.32 1.06e-9 Superior frontal gyrus grey matter volume; LUSC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs8072100 0.905 rs11651766 chr17:45574931 G/T cg08085267 chr17:45401833 C17orf57 -0.54 -8.6 -0.43 3.07e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg27535305 chr1:53392650 SCP2 -0.49 -9.75 -0.47 6.23e-20 Monocyte count; LUSC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg03233332 chr7:66118400 NA -0.41 -6.01 -0.31 4.84e-9 Aortic root size; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg00149659 chr3:10157352 C3orf10 0.91 11.55 0.53 3.41e-26 Alzheimer's disease; LUSC cis rs10782582 0.593 rs6675076 chr1:76118503 A/C cg03433033 chr1:76189801 ACADM -0.47 -7.29 -0.37 2.28e-12 Daytime sleep phenotypes; LUSC cis rs3740713 0.669 rs2896526 chr11:18419806 A/G cg07915343 chr11:18477680 LDHAL6A -0.47 -5.88 -0.31 9.74e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1018836 0.608 rs6982329 chr8:91467488 A/G cg16814680 chr8:91681699 NA -0.54 -7.89 -0.4 4.47e-14 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs3105593 0.901 rs3098200 chr15:50821945 G/A cg08437265 chr15:50716283 USP8 0.42 6.26 0.32 1.16e-9 QT interval; LUSC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg18876405 chr7:65276391 NA -0.58 -9.59 -0.46 2.13e-19 Aortic root size; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg07700962 chr1:174968950 CACYBP 0.54 6.81 0.35 4.5e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.84 -14.24 -0.61 2.78e-36 Menarche (age at onset); LUSC cis rs9472414 0.771 rs4714825 chr6:44761546 C/T cg20913747 chr6:44695427 NA 0.41 5.92 0.31 7.92e-9 Height; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03134551 chr8:681291 ERICH1 0.37 6.11 0.32 2.74e-9 Asthma; LUSC cis rs61931739 0.853 rs11053002 chr12:34083499 T/C cg06521331 chr12:34319734 NA 0.38 6.51 0.34 2.69e-10 Morning vs. evening chronotype; LUSC cis rs9287719 0.967 rs7570118 chr2:10718007 G/T cg00105475 chr2:10696890 NA 0.38 6.25 0.32 1.27e-9 Prostate cancer; LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg08200582 chr11:442649 ANO9 -0.53 -5.74 -0.3 2.07e-8 Body mass index; LUSC cis rs7072216 0.763 rs12763044 chr10:100167451 C/G cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg05347473 chr6:146136440 FBXO30 -0.48 -7.99 -0.4 2.25e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9427116 1.000 rs9427117 chr1:154632231 C/G cg17218026 chr1:154582156 ADAR 0.38 6.43 0.33 4.42e-10 Blood protein levels; LUSC cis rs2963155 0.518 rs56150733 chr5:142765099 T/C cg17617527 chr5:142782415 NR3C1 0.72 8.29 0.41 2.88e-15 Breast cancer; LUSC cis rs2425143 1.000 rs17093026 chr20:34318911 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.6 6.15 0.32 2.26e-9 Blood protein levels; LUSC cis rs4959270 0.967 rs4959914 chr6:453825 C/A cg09757644 chr6:447497 NA 0.28 5.76 0.3 1.88e-8 Limited cutaneous systemic scleroderma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03437924 chr16:25123326 LCMT1 -0.47 -6.58 -0.34 1.85e-10 Bipolar disorder and schizophrenia; LUSC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg27432699 chr2:27873401 GPN1 -0.58 -8.66 -0.43 2e-16 Total body bone mineral density; LUSC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.12 -0.32 2.62e-9 Alzheimer's disease (late onset); LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg08470875 chr2:26401718 FAM59B 0.74 9.89 0.48 2.15e-20 Gut microbiome composition (summer); LUSC cis rs6840360 0.550 rs62327267 chr4:152518753 G/T cg22705602 chr4:152727874 NA -0.33 -6.7 -0.34 9.13e-11 Intelligence (multi-trait analysis); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg17720231 chr1:159915374 IGSF9 0.4 6.42 0.33 4.68e-10 Calcium levels; LUSC cis rs6977940 0.558 rs11768054 chr7:2888015 T/G cg19731401 chr7:2775893 GNA12 0.71 7.84 0.39 5.97e-14 White matter integrity; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg10729496 chr3:10149963 C3orf24 -0.53 -6.06 -0.31 3.64e-9 Alzheimer's disease; LUSC trans rs7618501 0.602 rs2240326 chr3:50128386 G/A cg21659725 chr3:3221576 CRBN -0.65 -10.56 -0.5 1.07e-22 Intelligence (multi-trait analysis); LUSC cis rs2281845 0.965 rs3738263 chr1:201083506 A/G cg17810781 chr1:201082982 CACNA1S 0.33 6.32 0.33 8.58e-10 Permanent tooth development; LUSC cis rs858239 0.601 rs11984129 chr7:23152677 A/G cg23682824 chr7:23144976 KLHL7 0.4 5.79 0.3 1.62e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.8 9.29 0.45 2.08e-18 Mean platelet volume; LUSC cis rs4132509 0.739 rs79367267 chr1:243689543 C/A cg21452805 chr1:244014465 NA 0.61 6.22 0.32 1.45e-9 RR interval (heart rate); LUSC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.48 0.46 4.77e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11748023 0.605 rs185123 chr5:139517197 T/C cg26211634 chr5:139558579 C5orf32 0.35 6.19 0.32 1.75e-9 Intelligence (multi-trait analysis); LUSC cis rs6138458 0.620 rs914314 chr20:24897355 C/T cg26195577 chr20:24973756 C20orf3 -1.1 -11.33 -0.53 2.2e-25 Blood protein levels; LUSC cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.18 -0.41 6.14e-15 Axial length; LUSC cis rs806215 1.000 rs712697 chr7:127247132 T/A cg25922125 chr7:127225783 GCC1 0.57 7.17 0.37 4.96e-12 Type 2 diabetes; LUSC cis rs6012953 1.000 rs3787334 chr20:49128020 T/C cg13958625 chr20:49123093 NA 0.31 6.58 0.34 1.87e-10 Vitiligo; LUSC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg06634786 chr22:41940651 POLR3H 0.49 5.87 0.31 1.04e-8 Vitiligo; LUSC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.48 8.16 0.41 6.96e-15 Total body bone mineral density; LUSC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 11.35 0.53 1.75e-25 Personality dimensions; LUSC cis rs11122272 0.735 rs2790892 chr1:231512771 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs10050311 0.800 rs17420966 chr4:87692129 T/G cg10685359 chr4:87814065 C4orf36 -0.46 -5.77 -0.3 1.79e-8 Insulin-related traits; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.93 0.4 3.25e-14 Prudent dietary pattern; LUSC cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg24130564 chr14:104152367 KLC1 -0.47 -6.82 -0.35 4.31e-11 Intelligence (multi-trait analysis); LUSC cis rs7178572 0.568 rs1125617 chr15:77532711 A/G cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC trans rs7829975 0.626 rs332040 chr8:8730488 G/A cg21775007 chr8:11205619 TDH 0.54 7.79 0.39 8.59e-14 Mood instability; LUSC trans rs911555 0.755 rs8014013 chr14:103937372 A/G cg17675199 chr6:35436792 RPL10A -0.45 -6.51 -0.34 2.77e-10 Intelligence (multi-trait analysis); LUSC cis rs10992471 0.528 rs7022562 chr9:95216340 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.27 -0.32 1.14e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9815354 0.680 rs73075204 chr3:42030392 G/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs950169 0.580 rs1061737 chr15:85183790 G/C cg12863693 chr15:85201151 NMB 0.37 7.72 0.39 1.34e-13 Schizophrenia; LUSC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg08048268 chr3:133502702 NA -0.47 -8.96 -0.44 2.29e-17 Iron status biomarkers; LUSC cis rs2901656 1.000 rs2901656 chr1:172434812 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.3 6.13 0.32 2.46e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg11344533 chr11:111475393 SIK2 -0.49 -6.83 -0.35 4.02e-11 Primary sclerosing cholangitis; LUSC cis rs2404602 0.647 rs3812908 chr15:77176158 C/T cg23625390 chr15:77176239 SCAPER 0.61 9.1 0.45 8.34e-18 Blood metabolite levels; LUSC cis rs977987 0.835 rs7200616 chr16:75366089 G/A cg03315344 chr16:75512273 CHST6 0.54 10.48 0.5 2.15e-22 Dupuytren's disease; LUSC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg10523679 chr1:76189770 ACADM 0.85 13.88 0.6 6.99e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3741151 0.686 rs60860405 chr11:73248673 A/C cg17517138 chr11:73019481 ARHGEF17 0.82 7.61 0.38 2.82e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9467773 0.967 rs6924865 chr6:26521353 A/G cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.64e-42 Intelligence (multi-trait analysis); LUSC cis rs79149102 0.579 rs74023935 chr15:75359184 T/C cg09165964 chr15:75287851 SCAMP5 -0.87 -7.77 -0.39 9.65e-14 Lung cancer; LUSC trans rs561341 0.709 rs11542477 chr17:30185892 A/G cg20587970 chr11:113659929 NA 1.23 13.46 0.59 2.82e-33 Hip circumference adjusted for BMI; LUSC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg20639618 chr4:183729073 NA 0.64 8.32 0.41 2.23e-15 Pediatric autoimmune diseases; LUSC cis rs2445762 0.659 rs72729227 chr15:51670611 T/A cg07517944 chr15:51633816 GLDN 0.37 6.45 0.33 4.01e-10 Hormone measurements; LUSC cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.24 0.49 1.36e-21 Bladder cancer; LUSC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg24399712 chr22:39784796 NA -0.64 -11.52 -0.53 4.49e-26 Intelligence (multi-trait analysis); LUSC cis rs911119 0.657 rs13039144 chr20:23633755 A/G cg16589663 chr20:23618590 CST3 0.55 6.06 0.31 3.75e-9 Chronic kidney disease; LUSC cis rs713587 0.563 rs7591460 chr2:25103967 A/C cg01884057 chr2:25150051 NA 0.45 10.25 0.49 1.3e-21 Body mass index in non-asthmatics; LUSC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg09359103 chr1:154839909 KCNN3 -0.72 -17.09 -0.68 1.64e-47 Prostate cancer; LUSC cis rs3931020 0.671 rs1327088 chr1:75255491 A/G cg00121533 chr1:75199117 CRYZ;TYW3 0.47 7.33 0.37 1.72e-12 Resistin levels; LUSC cis rs7177699 0.557 rs7178051 chr15:79118296 A/G cg00540400 chr15:79124168 NA 0.48 8.48 0.42 7.16e-16 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg09877947 chr5:131593287 PDLIM4 -0.4 -6.69 -0.34 9.14e-11 Blood metabolite levels; LUSC cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg21535247 chr6:8435926 SLC35B3 0.6 9.36 0.46 1.23e-18 Motion sickness; LUSC cis rs9653442 0.900 rs6754937 chr2:100827720 T/G cg07810366 chr2:100720526 AFF3 -0.47 -7.9 -0.4 4.04e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2625529 0.775 rs62023342 chr15:72161305 A/C cg16672083 chr15:72433130 SENP8 -0.5 -7.32 -0.37 1.88e-12 Red blood cell count; LUSC cis rs3740713 1.000 rs76599129 chr11:18471627 T/A cg23797887 chr11:18477753 LDHAL6A -0.56 -6.75 -0.35 6.38e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1335645 0.570 rs61804560 chr1:111644247 G/A cg00321911 chr1:111669324 DRAM2 -0.56 -6.0 -0.31 5.01e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2969070 1.000 rs2895171 chr7:2514209 G/A cg03277898 chr7:2518824 NA -0.26 -5.68 -0.3 2.99e-8 Diastolic blood pressure; LUSC cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg10018233 chr7:150070692 REPIN1 0.35 5.94 0.31 7.05e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs965469 1.000 rs6037535 chr20:3270621 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -5.65 -0.3 3.51e-8 IFN-related cytopenia; LUSC trans rs12510870 0.511 rs16849366 chr4:74293387 C/T cg01940055 chr4:146018582 ANAPC10;ABCE1 0.39 6.39 0.33 5.68e-10 Iris color (b* coordinate); LUSC cis rs3892630 1.000 rs3892630 chr19:33181484 A/G cg22980127 chr19:33182716 NUDT19 -0.92 -12.61 -0.57 4.27e-30 Red blood cell traits; LUSC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.12e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs12122100 0.651 rs12127461 chr1:146551888 C/G cg03526459 chr1:146549940 NA -0.4 -6.69 -0.34 9.53e-11 HIV-1 control; LUSC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg08048268 chr3:133502702 NA -0.39 -7.08 -0.36 8.63e-12 Iron status biomarkers; LUSC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg10523679 chr1:76189770 ACADM 0.88 12.55 0.57 7.36e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17155006 0.746 rs435522 chr7:107748701 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC trans rs1991651 0.578 rs11778453 chr8:10489836 C/G cg15556689 chr8:8085844 FLJ10661 -0.43 -6.14 -0.32 2.3e-9 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; LUSC cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg24692254 chr21:30365293 RNF160 0.92 19.4 0.73 1.15e-56 Dental caries; LUSC cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg13010199 chr12:38710504 ALG10B 0.65 10.25 0.49 1.32e-21 Bladder cancer; LUSC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg25019033 chr10:957182 NA -0.48 -5.75 -0.3 1.97e-8 Eosinophil percentage of granulocytes; LUSC cis rs73206853 0.764 rs12311093 chr12:110978032 A/G cg12870014 chr12:110450643 ANKRD13A -0.72 -9.54 -0.46 3.17e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2204008 0.654 rs1733410 chr12:38132172 G/A cg13010199 chr12:38710504 ALG10B -0.53 -7.94 -0.4 3.11e-14 Bladder cancer; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg20887711 chr4:1340912 KIAA1530 0.47 7.15 0.36 5.57e-12 Obesity-related traits; LUSC cis rs79149102 0.579 rs61166993 chr15:75306644 C/A cg17294928 chr15:75287854 SCAMP5 -0.69 -6.29 -0.33 9.97e-10 Lung cancer; LUSC cis rs4776059 0.798 rs1080731 chr15:52920658 C/T cg22715398 chr15:52968154 KIAA1370 -0.54 -7.21 -0.37 3.65e-12 Schizophrenia; LUSC cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.37 -0.42 1.63e-15 Schizophrenia; LUSC cis rs2439831 0.850 rs28696802 chr15:44140395 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.54 0.42 4.94e-16 Lung cancer in ever smokers; LUSC cis rs4356932 0.967 rs7436646 chr4:76955229 T/G cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs6939532 0.522 rs6933583 chr6:26355283 A/C cg09904177 chr6:26538194 HMGN4 -0.41 -5.79 -0.3 1.66e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg11645453 chr3:52864694 ITIH4 0.29 6.73 0.35 7.46e-11 Electroencephalogram traits; LUSC cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg00012203 chr2:219082015 ARPC2 0.76 13.51 0.59 1.81e-33 Colorectal cancer; LUSC cis rs10028773 0.506 rs12374346 chr4:120281705 G/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Educational attainment; LUSC cis rs10750766 1 rs10750766 chr11:65473798 C/A cg10518572 chr11:65560635 OVOL1 -0.25 -5.82 -0.3 1.4e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs977987 0.806 rs11641587 chr16:75464419 G/T cg03315344 chr16:75512273 CHST6 0.5 9.55 0.46 2.98e-19 Dupuytren's disease; LUSC cis rs11792861 0.926 rs72607172 chr9:111876523 A/G cg13535736 chr9:111863775 C9orf5 -0.42 -6.88 -0.35 2.95e-11 Menarche (age at onset); LUSC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg12257692 chr3:49977190 RBM6 -0.26 -7.22 -0.37 3.63e-12 Intelligence (multi-trait analysis); LUSC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg27572855 chr1:25598939 RHD 0.43 7.68 0.39 1.78e-13 Erythrocyte sedimentation rate; LUSC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg12386194 chr3:101231763 SENP7 0.54 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9300255 0.506 rs61388686 chr12:123810873 G/A cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.12 -0.41 9.24e-15 Neutrophil percentage of white cells; LUSC cis rs2729354 1.000 rs2649662 chr11:57352562 G/T cg24343310 chr11:57249947 NA -0.36 -6.51 -0.34 2.82e-10 Blood protein levels; LUSC cis rs4842666 0.915 rs111478946 chr12:90058842 G/A cg00757033 chr12:89920650 WDR51B 0.49 6.97 0.36 1.7e-11 Blood pressure; LUSC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg27535305 chr1:53392650 SCP2 -0.37 -6.73 -0.35 7.44e-11 Monocyte count; LUSC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg13175981 chr1:150552382 MCL1 -0.41 -5.7 -0.3 2.69e-8 Melanoma; LUSC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg13393036 chr8:95962371 TP53INP1 -0.45 -9.49 -0.46 4.41e-19 Type 2 diabetes; LUSC cis rs10911232 0.507 rs10797822 chr1:183017769 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.91 0.51 6.56e-24 Hypertriglyceridemia; LUSC trans rs7613875 0.663 rs6762477 chr3:50093209 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -8.0 -0.4 2.03e-14 Body mass index; LUSC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg23743428 chr13:21893420 NA -0.45 -8.97 -0.44 2.15e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs5758659 0.714 rs2413668 chr22:42505841 G/A cg00645731 chr22:42541494 CYP2D7P1 0.28 5.66 0.3 3.33e-8 Cognitive function; LUSC cis rs921968 0.541 rs7574429 chr2:219498759 T/G cg02176678 chr2:219576539 TTLL4 0.72 14.12 0.61 7.95e-36 Mean corpuscular hemoglobin concentration; LUSC trans rs7824557 0.527 rs11785394 chr8:11238029 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -7.75 -0.39 1.15e-13 Retinal vascular caliber; LUSC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg16405210 chr4:1374714 KIAA1530 -0.5 -6.92 -0.35 2.35e-11 Obesity-related traits; LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.39 0.59 4.96e-33 Platelet count; LUSC cis rs9788682 1.000 rs9788682 chr15:78802586 A/G cg06917634 chr15:78832804 PSMA4 0.55 6.44 0.33 4.05e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.59 0.6 8.31e-34 Platelet count; LUSC cis rs367615 0.506 rs1428932 chr5:108792479 A/G cg17395555 chr5:108820864 NA -0.54 -9.95 -0.48 1.32e-20 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg11266682 chr4:10021025 SLC2A9 0.51 9.26 0.45 2.5e-18 Bone mineral density; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg16145915 chr7:1198662 ZFAND2A -0.59 -10.96 -0.51 4.28e-24 Longevity;Endometriosis; LUSC cis rs9341835 0.510 rs2622284 chr6:64193572 T/C cg03326410 chr6:64151739 NA 0.36 5.77 0.3 1.83e-8 Schizophrenia; LUSC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg04944784 chr2:26401820 FAM59B -0.69 -9.7 -0.47 9.37e-20 Gut microbiome composition (summer); LUSC cis rs8022179 0.580 rs58153827 chr14:103844630 G/A cg12935359 chr14:103987150 CKB 0.66 8.66 0.43 1.98e-16 Monocyte count; LUSC cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.56 0.5 1.12e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg19318889 chr4:1322082 MAEA 0.46 7.45 0.38 8e-13 Obesity-related traits; LUSC cis rs8014204 0.762 rs10138360 chr14:75293386 A/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -8.09 -0.4 1.14e-14 Caffeine consumption; LUSC cis rs6690583 0.512 rs7547224 chr1:85456902 T/C cg22153463 chr1:85462885 MCOLN2 0.62 5.7 0.3 2.68e-8 Serum sulfate level; LUSC trans rs561341 0.941 rs2428336 chr17:30290577 T/C cg27661571 chr11:113659931 NA -0.59 -6.93 -0.35 2.15e-11 Hip circumference adjusted for BMI; LUSC cis rs11122272 0.735 rs2246645 chr1:231497393 T/G cg06096015 chr1:231504339 EGLN1 0.56 9.83 0.47 3.27e-20 Hemoglobin concentration; LUSC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg14895029 chr7:2775587 GNA12 -0.41 -6.13 -0.32 2.47e-9 Height; LUSC cis rs3749237 0.929 rs62260715 chr3:49829326 G/A cg03060546 chr3:49711283 APEH 0.61 8.41 0.42 1.22e-15 Resting heart rate; LUSC cis rs17621444 0.522 rs10788022 chr10:121812113 A/C cg02041677 chr10:121771263 NA -0.32 -6.02 -0.31 4.59e-9 IgG glycosylation; LUSC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg10523679 chr1:76189770 ACADM 0.9 13.0 0.58 1.5e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs860295 0.702 rs12041534 chr1:155407096 A/G cg02153340 chr1:155202674 NA 0.37 5.72 0.3 2.39e-8 Body mass index; LUSC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg20203395 chr5:56204925 C5orf35 0.51 7.43 0.38 9e-13 Type 2 diabetes; LUSC cis rs600231 0.542 rs10896008 chr11:65245904 C/G cg17120908 chr11:65337727 SSSCA1 -0.63 -9.04 -0.44 1.25e-17 Bone mineral density; LUSC cis rs9807989 0.839 rs4988955 chr2:102967928 A/G cg09003973 chr2:102972529 NA 0.44 6.14 0.32 2.39e-9 Asthma; LUSC cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.38 0.69 1.15e-48 Chronic sinus infection; LUSC cis rs7618501 1.000 rs2234391 chr3:49842625 A/G cg24110177 chr3:50126178 RBM5 -0.41 -6.68 -0.34 1.01e-10 Intelligence (multi-trait analysis); LUSC cis rs354225 0.544 rs13423873 chr2:54786677 A/G cg01766943 chr2:54829624 SPTBN1 0.49 7.54 0.38 4.57e-13 Schizophrenia; LUSC cis rs9479482 1.000 rs5017316 chr6:150333489 A/T cg07578070 chr6:150326732 RAET1K 0.4 6.29 0.33 9.97e-10 Alopecia areata; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19478983 chr7:120590592 ING3 0.4 6.96 0.36 1.83e-11 Triglycerides; LUSC cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.1e-40 Bladder cancer; LUSC cis rs9486719 0.948 rs2499813 chr6:96875338 T/C cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs4588572 0.643 rs7716529 chr5:77738637 A/T cg11547950 chr5:77652471 NA -0.54 -7.88 -0.4 4.8e-14 Triglycerides; LUSC cis rs7267979 1.000 rs4815404 chr20:25301845 T/G cg08601574 chr20:25228251 PYGB -0.44 -6.72 -0.35 7.65e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10791323 0.569 rs1119852 chr11:133743022 C/A cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.47 0.38 7.01e-13 Motion sickness; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg04267008 chr7:1944627 MAD1L1 -0.66 -10.22 -0.49 1.58e-21 Bipolar disorder and schizophrenia; LUSC cis rs13385 0.723 rs36078551 chr5:139532339 C/T cg26211634 chr5:139558579 C5orf32 0.41 5.97 0.31 6.08e-9 Atrial fibrillation; LUSC cis rs908922 0.627 rs11590073 chr1:152500810 C/T cg20991723 chr1:152506922 NA 0.53 9.87 0.48 2.41e-20 Hair morphology; LUSC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.93 -0.72 8.57e-55 Height; LUSC cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg00074818 chr8:8560427 CLDN23 0.59 9.8 0.47 4.21e-20 Obesity-related traits; LUSC cis rs7597155 0.935 rs7577493 chr2:69980174 T/G cg02498382 chr2:70120550 SNRNP27 -0.25 -5.87 -0.31 1.03e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6847149 0.929 rs11937583 chr4:110808173 A/G cg07850274 chr4:110748770 RRH 0.52 7.07 0.36 9.07e-12 Exercise treadmill test traits; LUSC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg22823121 chr1:150693482 HORMAD1 -0.45 -6.63 -0.34 1.35e-10 Tonsillectomy; LUSC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.94 -12.22 -0.56 1.24e-28 Platelet count; LUSC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg05623727 chr3:50126028 RBM5 -0.33 -6.22 -0.32 1.51e-9 Body mass index; LUSC cis rs911555 0.723 rs6575982 chr14:103862681 G/A cg24130564 chr14:104152367 KLC1 0.43 6.1 0.32 2.86e-9 Intelligence (multi-trait analysis); LUSC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg17252645 chr8:143867129 LY6D -0.34 -5.64 -0.3 3.54e-8 Urinary tract infection frequency; LUSC cis rs2273669 0.667 rs12196143 chr6:109302372 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg05665937 chr4:1216051 CTBP1 0.35 5.73 0.3 2.2e-8 Obesity-related traits; LUSC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg13175981 chr1:150552382 MCL1 0.47 6.78 0.35 5.34e-11 Tonsillectomy; LUSC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg07636037 chr3:49044803 WDR6 0.88 13.32 0.59 9.28e-33 Menarche (age at onset); LUSC cis rs748404 0.697 rs579651 chr15:43558376 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.33 0.41 2.18e-15 Lung cancer; LUSC cis rs11098499 0.955 rs7685268 chr4:120162188 G/A cg09307838 chr4:120376055 NA 0.71 10.32 0.49 7.35e-22 Corneal astigmatism; LUSC cis rs13272568 0.502 rs10957882 chr8:78995713 C/A cg00738934 chr8:78996279 NA 0.37 6.16 0.32 2.08e-9 Bone mineral density; LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg21782813 chr7:2030301 MAD1L1 0.43 7.04 0.36 1.07e-11 Bipolar disorder and schizophrenia; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg07806771 chr7:64541737 NA -0.43 -6.32 -0.33 8.47e-10 Calcium levels; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg14004847 chr7:1930337 MAD1L1 -0.53 -7.87 -0.4 4.95e-14 Bipolar disorder and schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25992645 chr11:65244888 NA -0.48 -6.12 -0.32 2.68e-9 Bipolar disorder and schizophrenia; LUSC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg04511125 chr2:88470314 THNSL2 0.96 9.39 0.46 9.75e-19 Plasma clusterin levels; LUSC cis rs68170813 0.652 rs6958969 chr7:107197755 A/T cg02696742 chr7:106810147 HBP1 -0.64 -8.57 -0.42 3.82e-16 Coronary artery disease; LUSC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg22535103 chr8:58192502 C8orf71 -0.7 -7.31 -0.37 1.97e-12 Developmental language disorder (linguistic errors); LUSC cis rs929354 0.742 rs886677 chr7:157003782 T/A cg05182265 chr7:156933206 UBE3C -0.6 -9.69 -0.47 9.72e-20 Body mass index; LUSC cis rs62400317 0.859 rs72869127 chr6:45071712 T/C cg20913747 chr6:44695427 NA -0.46 -7.43 -0.38 9.41e-13 Total body bone mineral density; LUSC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg02376097 chr19:46275166 DMPK 0.39 6.93 0.35 2.22e-11 Coronary artery disease; LUSC cis rs10197940 0.624 rs10497081 chr2:152353395 T/G cg06191203 chr2:152266755 RIF1 -0.54 -7.28 -0.37 2.41e-12 Lung cancer; LUSC cis rs17604090 0.938 rs28664977 chr7:29685369 C/T cg19413766 chr7:29689036 LOC646762 -0.58 -6.93 -0.35 2.12e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.65 0.47 1.38e-19 Personality dimensions; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02621907 chr5:93954419 ANKRD32;C5orf36 0.45 6.44 0.33 4.06e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg03433033 chr1:76189801 ACADM -0.65 -8.92 -0.44 3.2e-17 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9399135 0.967 rs7741626 chr6:135314182 C/T cg22676075 chr6:135203613 NA 0.48 7.48 0.38 6.5e-13 Red blood cell count; LUSC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs1832871 0.672 rs9456289 chr6:158740347 G/A cg07165851 chr6:158734300 TULP4 0.45 6.8 0.35 4.96e-11 Height; LUSC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg09877947 chr5:131593287 PDLIM4 -0.34 -5.72 -0.3 2.39e-8 Blood metabolite levels; LUSC cis rs6696846 0.630 rs6692706 chr1:205158561 G/T cg21643547 chr1:205240462 TMCC2 -0.43 -7.81 -0.39 7.28e-14 Red blood cell count; LUSC cis rs981844 1.000 rs62325093 chr4:154669733 G/A cg14289246 chr4:154710475 SFRP2 0.48 5.97 0.31 5.94e-9 Response to statins (LDL cholesterol change); LUSC cis rs6542838 0.611 rs6742047 chr2:99531460 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.64 -0.34 1.3e-10 Fear of minor pain; LUSC cis rs7215564 0.908 rs9972968 chr17:78652569 T/C cg23238734 chr17:78661607 RPTOR 0.51 6.55 0.34 2.2e-10 Myopia (pathological); LUSC cis rs7089973 0.525 rs11196945 chr10:116600424 G/A cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1865760 1.000 rs3830057 chr6:25918510 G/T cg16482183 chr6:26056742 HIST1H1C 0.44 6.49 0.33 3.11e-10 Height; LUSC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg15744005 chr10:104629667 AS3MT -0.28 -5.88 -0.31 9.93e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg07677032 chr17:61819896 STRADA 0.55 9.09 0.45 9.21e-18 Prudent dietary pattern; LUSC cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg04586622 chr2:25135609 ADCY3 0.43 9.23 0.45 3.12e-18 Body mass index; LUSC cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.53 -0.5 1.36e-22 Glomerular filtration rate (creatinine); LUSC trans rs10511400 0.618 rs4676809 chr3:119907244 C/T cg02809009 chr19:50354510 PTOV1 0.68 6.34 0.33 7.27e-10 Economic and political preferences (feminism/equality); LUSC cis rs11711311 1.000 rs12497716 chr3:113453258 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.53 7.31 0.37 1.99e-12 IgG glycosylation; LUSC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg23583168 chr7:148888333 NA -0.85 -14.77 -0.63 2.33e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs61931739 1.000 rs12305700 chr12:34036332 T/C cg13010199 chr12:38710504 ALG10B -0.4 -6.04 -0.31 4.04e-9 Morning vs. evening chronotype; LUSC cis rs75920871 0.588 rs7118591 chr11:116908457 A/C cg01368799 chr11:117014884 PAFAH1B2 0.51 6.49 0.33 3.17e-10 Subjective well-being; LUSC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.49 9.23 0.45 3.15e-18 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs243505 0.660 rs243487 chr7:148448211 G/A cg09806900 chr7:148480153 CUL1 -0.54 -7.05 -0.36 1.04e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.97 0.77 8.13e-67 Prudent dietary pattern; LUSC cis rs76878669 0.561 rs7107191 chr11:66140397 G/A cg18002602 chr11:66138449 SLC29A2 0.45 8.14 0.41 8.11e-15 Educational attainment (years of education); LUSC cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg13010199 chr12:38710504 ALG10B 0.65 9.82 0.47 3.81e-20 Bladder cancer; LUSC cis rs593982 0.843 rs552312 chr11:65477349 C/T cg08755490 chr11:65554678 OVOL1 1.53 13.65 0.6 5.31e-34 Atopic dermatitis; LUSC cis rs6700896 0.931 rs2154384 chr1:66108517 C/T cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs6582630 0.519 rs12372510 chr12:38293074 T/C cg06521331 chr12:34319734 NA -0.4 -6.11 -0.32 2.85e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20174699 chr12:50222232 LOC100286844;NCKAP5L -0.41 -6.29 -0.33 9.87e-10 Hepatitis; LUSC cis rs7909074 0.691 rs11239274 chr10:45393219 A/C cg05187965 chr10:45406764 TMEM72 0.31 6.77 0.35 5.72e-11 Mean corpuscular volume; LUSC cis rs6570726 0.967 rs439017 chr6:145806123 T/C cg23711669 chr6:146136114 FBXO30 0.71 12.46 0.56 1.54e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg15445000 chr17:37608096 MED1 0.4 6.81 0.35 4.65e-11 Glomerular filtration rate (creatinine); LUSC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg20307385 chr11:47447363 PSMC3 -0.47 -5.98 -0.31 5.64e-9 Subjective well-being; LUSC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg26441486 chr22:50317300 CRELD2 0.5 7.66 0.39 2.08e-13 Schizophrenia; LUSC cis rs6665290 0.901 rs2104860 chr1:227208637 G/C cg10327440 chr1:227177885 CDC42BPA -1.23 -39.64 -0.91 2.47e-128 Myeloid white cell count; LUSC cis rs6901250 0.632 rs688961 chr6:117089080 A/T cg12892004 chr6:117198278 RFX6 0.36 6.63 0.34 1.35e-10 C-reactive protein levels; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 6.62 0.34 1.45e-10 Platelet count; LUSC trans rs61931739 0.534 rs28548399 chr12:34188151 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.46e-16 Morning vs. evening chronotype; LUSC cis rs6138458 0.626 rs6132789 chr20:25012809 C/T cg26195577 chr20:24973756 C20orf3 -0.68 -10.48 -0.5 2.14e-22 Blood protein levels; LUSC cis rs5770917 1.000 rs17848459 chr22:51012311 G/T cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.62 -5.74 -0.3 2.07e-8 Narcolepsy; LUSC cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg08754478 chr10:133766260 PPP2R2D -0.63 -7.99 -0.4 2.27e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs7760949 0.963 rs1330118 chr6:13921016 C/T cg27413430 chr6:13925136 RNF182 -0.41 -5.79 -0.3 1.59e-8 Mean corpuscular hemoglobin concentration; LUSC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.76 0.39 1.01e-13 Major depressive disorder; LUSC cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.36 0.53 1.69e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs17253792 0.822 rs13379340 chr14:56050346 C/G cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC trans rs1973993 0.934 rs588660 chr1:96886604 G/A cg10631902 chr5:14652156 NA 0.56 9.46 0.46 5.6e-19 Weight; LUSC cis rs9341808 0.754 rs9341811 chr6:80982701 G/A cg08355045 chr6:80787529 NA 0.56 9.8 0.47 4.14e-20 Sitting height ratio; LUSC cis rs9902453 0.817 rs17226179 chr17:28168573 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.95 0.48 1.38e-20 Coffee consumption (cups per day); LUSC cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg07148914 chr20:33460835 GGT7 -0.54 -8.31 -0.41 2.39e-15 Height; LUSC cis rs7215564 0.730 rs2316066 chr17:78659785 A/G cg09596252 chr17:78655493 RPTOR 0.55 6.05 0.31 3.92e-9 Myopia (pathological); LUSC cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg14530993 chr4:882597 GAK -0.71 -7.49 -0.38 6.12e-13 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg12549451 chr6:135224345 NA -0.35 -5.8 -0.3 1.57e-8 Red blood cell count; LUSC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg16989086 chr20:62203971 PRIC285 0.44 6.14 0.32 2.3e-9 Glioblastoma; LUSC cis rs752010 0.695 rs10789408 chr1:42106579 T/C cg06885757 chr1:42089581 HIVEP3 0.44 8.59 0.43 3.36e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7119 0.717 rs11629835 chr15:77787469 G/T cg27398640 chr15:77910606 LINGO1 -0.29 -5.93 -0.31 7.41e-9 Type 2 diabetes; LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg05368731 chr17:41323189 NBR1 0.92 15.84 0.66 1.49e-42 Menopause (age at onset); LUSC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg12923728 chr3:195709715 SDHAP1 -0.79 -12.47 -0.56 1.41e-29 Pancreatic cancer; LUSC cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.94 -0.31 7.19e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs921968 0.565 rs7599568 chr2:219607819 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.17 -0.49 2.38e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg26384229 chr12:38710491 ALG10B -0.83 -15.22 -0.64 4.25e-40 Heart rate; LUSC cis rs9584850 0.834 rs7985565 chr13:99113471 C/G cg07423050 chr13:99094983 FARP1 0.37 6.04 0.31 4.17e-9 Neuroticism; LUSC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.81 -0.35 4.56e-11 Glomerular filtration rate (creatinine); LUSC cis rs12122100 0.689 rs12129419 chr1:146546703 A/G cg03526459 chr1:146549940 NA -0.41 -6.73 -0.35 7.59e-11 HIV-1 control; LUSC cis rs9393777 0.920 rs35869525 chr6:26946687 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.57 -5.66 -0.3 3.24e-8 Intelligence (multi-trait analysis); LUSC cis rs79349575 0.783 rs12453374 chr17:46994846 G/C cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg04850211 chr1:228464232 OBSCN 0.35 6.28 0.32 1.07e-9 Diastolic blood pressure; LUSC cis rs4939490 0.639 rs2905517 chr11:60768044 G/A cg16817237 chr11:60793675 NA -0.4 -7.75 -0.39 1.13e-13 Multiple sclerosis; LUSC trans rs7618501 0.633 rs4688757 chr3:50035323 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.15 0.45 5.56e-18 Intelligence (multi-trait analysis); LUSC cis rs9467711 0.659 rs35433030 chr6:26529890 G/A cg09904177 chr6:26538194 HMGN4 -0.79 -6.14 -0.32 2.29e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7589342 0.831 rs6714861 chr2:106518893 C/T cg14210321 chr2:106509881 NCK2 0.56 8.66 0.43 2.03e-16 Addiction; LUSC cis rs2073300 1.000 rs6114144 chr20:23462022 A/T cg09953122 chr20:23471693 CST8 -0.73 -7.41 -0.38 1.03e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7202877 0.656 rs6564245 chr16:75308899 A/G cg04384234 chr16:75411784 CFDP1 0.64 8.63 0.43 2.55e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.89 0.31 9.33e-9 Menopause (age at onset); LUSC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg07870213 chr5:140052090 DND1 -0.75 -11.13 -0.52 1.11e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs17401966 0.838 rs34636442 chr1:10427459 T/G cg19773385 chr1:10388646 KIF1B -0.5 -8.68 -0.43 1.82e-16 Hepatocellular carcinoma; LUSC cis rs79839061 0.610 rs62297062 chr4:869698 C/T cg23992470 chr4:843637 GAK 0.6 6.4 0.33 5.14e-10 Intelligence (multi-trait analysis); LUSC cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg01884057 chr2:25150051 NA 0.42 9.13 0.45 6.57e-18 Body mass index; LUSC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg16447950 chr5:562315 NA -0.58 -7.03 -0.36 1.15e-11 Lung disease severity in cystic fibrosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00366471 chr15:71184982 LRRC49;THAP10 0.46 6.66 0.34 1.14e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1568889 0.838 rs11030230 chr11:28174631 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.64 0.57 3.29e-30 Bipolar disorder; LUSC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg17366294 chr4:99064904 C4orf37 0.5 8.29 0.41 2.84e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.49 6.14 0.32 2.31e-9 Schizophrenia; LUSC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg25204440 chr1:209979598 IRF6 0.53 7.08 0.36 8.6e-12 Cleft lip with or without cleft palate; LUSC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg04352962 chr1:209979756 IRF6 0.56 6.1 0.32 2.89e-9 Cleft lip with or without cleft palate; LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs17095355 1.000 rs11194940 chr10:111742223 G/A cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.36 -0.37 1.43e-12 Biliary atresia; LUSC cis rs6701037 1.000 rs6659824 chr1:175125378 C/A cg00321850 chr1:175162397 KIAA0040 -0.4 -6.9 -0.35 2.55e-11 Alcohol dependence; LUSC cis rs1018836 0.700 rs12678527 chr8:91527411 T/C cg16814680 chr8:91681699 NA -0.73 -11.29 -0.53 2.89e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs600231 0.598 rs2508712 chr11:65232261 C/G cg17120908 chr11:65337727 SSSCA1 -0.54 -9.3 -0.45 1.9e-18 Bone mineral density; LUSC cis rs9811920 0.809 rs793464 chr3:99626028 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 7.54 0.38 4.55e-13 Axial length; LUSC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg17333051 chr19:2783644 SGTA 0.49 7.36 0.37 1.46e-12 Total cholesterol levels; LUSC cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -1.22 -29.5 -0.85 4.95e-95 Chronic sinus infection; LUSC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg03929089 chr4:120376271 NA 0.95 15.15 0.64 7.72e-40 Coronary artery disease; LUSC cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.99 0.36 1.46e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs1499614 1.000 rs2659903 chr7:66180931 G/A cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC trans rs11039798 0.688 rs8188953 chr11:48749201 A/T cg03929089 chr4:120376271 NA 0.74 6.91 0.35 2.4e-11 Axial length; LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg16405210 chr4:1374714 KIAA1530 -0.55 -8.29 -0.41 2.71e-15 Obesity-related traits; LUSC cis rs7582720 1.000 rs72926767 chr2:203796814 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.34 0.42 1.98e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg21535247 chr6:8435926 SLC35B3 0.58 9.0 0.44 1.77e-17 Motion sickness; LUSC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg10018233 chr7:150070692 REPIN1 0.36 6.19 0.32 1.77e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6426558 0.537 rs498020 chr1:227304180 G/A cg10327440 chr1:227177885 CDC42BPA 0.54 7.39 0.37 1.18e-12 Neutrophil percentage of white cells; LUSC cis rs13392177 0.672 rs1877715 chr2:219052546 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.44 6.67 0.34 1.05e-10 Pyoderma gangrenosum in inflammatory bowel disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13763308 chr10:75910788 AP3M1;ADK -0.5 -7.03 -0.36 1.16e-11 Electrocardiographic conduction measures; LUSC trans rs7849782 1.000 rs7849782 chr9:104427264 C/G cg22914338 chr19:14376960 NA -0.25 -6.11 -0.32 2.82e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg23758822 chr17:41437982 NA 1.04 19.29 0.73 2.97e-56 Menopause (age at onset); LUSC cis rs8062405 1.000 rs62037364 chr16:28868695 G/A cg05966235 chr16:28915196 ATP2A1 0.32 5.71 0.3 2.51e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg13010199 chr12:38710504 ALG10B -0.64 -11.11 -0.52 1.32e-24 Heart rate; LUSC cis rs7106204 0.764 rs79362440 chr11:24212972 G/A ch.11.24196551F chr11:24239977 NA 0.89 7.48 0.38 6.45e-13 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9443189 0.570 rs775075 chr6:76380035 A/C cg01950844 chr6:76311363 SENP6 -0.68 -6.84 -0.35 3.85e-11 Prostate cancer; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg22907277 chr7:1156413 C7orf50 0.47 7.22 0.37 3.47e-12 Longevity;Endometriosis; LUSC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg09998033 chr7:158218633 PTPRN2 -0.6 -9.67 -0.47 1.16e-19 Obesity-related traits; LUSC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg15147215 chr3:52552868 STAB1 -0.32 -6.39 -0.33 5.65e-10 Bipolar disorder; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg14159672 chr1:205819179 PM20D1 0.89 16.3 0.67 2.43e-44 Menarche (age at onset); LUSC cis rs2624839 0.679 rs2624835 chr3:50209049 G/A cg24110177 chr3:50126178 RBM5 -0.51 -7.83 -0.39 6.58e-14 Intelligence (multi-trait analysis); LUSC cis rs950169 0.922 rs11633534 chr15:85124642 C/T cg17173187 chr15:85201210 NMB 0.38 6.65 0.34 1.21e-10 Schizophrenia; LUSC cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg11057378 chr10:81107060 PPIF 0.38 6.43 0.33 4.48e-10 Height; LUSC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.61 -5.96 -0.31 6.44e-9 Cerebrospinal P-tau181p levels; LUSC cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.59 -0.46 2.18e-19 Chronic sinus infection; LUSC cis rs7527798 0.571 rs4844611 chr1:207827538 G/C cg09232269 chr1:207846808 CR1L -0.3 -6.36 -0.33 6.48e-10 Erythrocyte sedimentation rate; LUSC cis rs140244541 1 rs140244541 chr2:203808532 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.65 6.91 0.35 2.42e-11 LDL cholesterol; LUSC trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg03929089 chr4:120376271 NA 0.61 6.6 0.34 1.65e-10 Axial length; LUSC cis rs9389248 0.690 rs2064101 chr6:135250530 G/A cg22676075 chr6:135203613 NA -0.65 -10.24 -0.49 1.41e-21 High light scatter reticulocyte percentage of red cells; LUSC cis rs9549260 0.632 rs7323267 chr13:41204015 A/G cg21288729 chr13:41239152 FOXO1 0.58 6.66 0.34 1.15e-10 Red blood cell count; LUSC cis rs9928842 0.722 rs1035540 chr16:75278795 A/G cg09066997 chr16:75300724 BCAR1 0.51 6.54 0.34 2.31e-10 Alcoholic chronic pancreatitis; LUSC cis rs473651 0.904 rs508274 chr2:239337723 G/A cg21699342 chr2:239360505 ASB1 0.56 10.54 0.5 1.28e-22 Multiple system atrophy; LUSC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg08847533 chr14:75593920 NEK9 -0.82 -15.13 -0.64 9.25e-40 Height; LUSC cis rs868036 0.718 rs4776982 chr15:68114974 C/T cg05925327 chr15:68127851 NA 0.39 6.08 0.32 3.35e-9 Restless legs syndrome; LUSC trans rs2708977 0.665 rs772173 chr2:97000396 C/T cg10782065 chr14:60823282 NA 0.37 6.17 0.32 1.94e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg17971929 chr21:40555470 PSMG1 0.69 11.38 0.53 1.46e-25 Cognitive function; LUSC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg27539214 chr16:67997921 SLC12A4 -0.57 -7.57 -0.38 3.6e-13 HDL cholesterol;Metabolic syndrome; LUSC trans rs2018683 0.523 rs886834 chr7:29021336 G/A cg19402173 chr7:128379420 CALU -0.46 -6.86 -0.35 3.31e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.46 6.92 0.35 2.35e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg23758822 chr17:41437982 NA 1.03 19.13 0.72 1.36e-55 Menopause (age at onset); LUSC cis rs6541297 0.938 rs1555289 chr1:230292499 C/T cg20703242 chr1:230279135 GALNT2 -0.63 -8.76 -0.43 1.03e-16 Coronary artery disease; LUSC cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg09184832 chr6:79620586 NA -0.44 -7.24 -0.37 3.16e-12 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs1288775 chr15:45661678 T/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.62 0.75 1.62e-61 Homoarginine levels; LUSC trans rs57221529 0.766 rs17497684 chr5:558307 T/C cg25482853 chr8:67687455 SGK3 1.19 19.12 0.72 1.43e-55 Lung disease severity in cystic fibrosis; LUSC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg05855489 chr10:104503620 C10orf26 -0.69 -10.18 -0.49 2.31e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg15445000 chr17:37608096 MED1 0.4 6.89 0.35 2.83e-11 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg05313129 chr8:58192883 C8orf71 -0.49 -6.72 -0.35 7.96e-11 Developmental language disorder (linguistic errors); LUSC cis rs7178572 0.633 rs4886877 chr15:77838535 C/G cg22256960 chr15:77711686 NA -0.47 -7.04 -0.36 1.11e-11 Type 2 diabetes; LUSC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg19230755 chr7:65878503 NA -0.43 -6.02 -0.31 4.48e-9 Aortic root size; LUSC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg06363034 chr20:62225388 GMEB2 -0.46 -7.73 -0.39 1.32e-13 Glioblastoma; LUSC cis rs9325144 0.723 rs11169518 chr12:39177237 C/A cg13010199 chr12:38710504 ALG10B -0.49 -7.55 -0.38 4.18e-13 Morning vs. evening chronotype; LUSC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg20307385 chr11:47447363 PSMC3 -0.45 -5.97 -0.31 6.18e-9 Subjective well-being; LUSC cis rs6456156 0.586 rs2285148 chr6:167490999 G/T cg25258033 chr6:167368657 RNASET2 0.39 5.76 0.3 1.94e-8 Primary biliary cholangitis; LUSC trans rs2926702 0.810 rs2958370 chr8:71082718 A/G cg16517358 chr11:46164796 NA -0.4 -6.04 -0.31 4.09e-9 Non-small cell lung cancer; LUSC cis rs72781680 0.950 rs72796402 chr2:24180104 A/G cg20701182 chr2:24300061 SF3B14 0.78 7.8 0.39 7.8500000000000006e-14 Lymphocyte counts; LUSC cis rs7180079 0.620 rs500641 chr15:64851132 C/T cg08069370 chr15:64387884 SNX1 0.51 5.74 0.3 2.13e-8 Monocyte count; LUSC trans rs1005277 0.579 rs2474599 chr10:38438939 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.34 -0.46 1.42e-18 Extrinsic epigenetic age acceleration; LUSC trans rs61931739 0.853 rs7133716 chr12:34041847 G/C cg26384229 chr12:38710491 ALG10B -0.51 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs7927771 0.507 rs11039432 chr11:47873327 G/A cg20307385 chr11:47447363 PSMC3 0.46 6.76 0.35 6.07e-11 Subjective well-being; LUSC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg26659404 chr1:25747437 RHCE 0.28 5.82 0.3 1.37e-8 Erythrocyte sedimentation rate; LUSC cis rs3008870 0.958 rs12131222 chr1:67438535 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs2617583 0.509 rs2937650 chr5:1458018 C/T cg13982541 chr5:1466431 LPCAT1 -0.44 -6.46 -0.33 3.77e-10 Breast cancer; LUSC cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg23711669 chr6:146136114 FBXO30 0.8 14.41 0.62 6.03e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.56 7.42 0.38 9.68e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.61 -0.6 7.34e-34 Chronic sinus infection; LUSC cis rs10089 1.000 rs1864922 chr5:127420700 T/C cg19767477 chr5:127420684 SLC12A2 -0.42 -5.83 -0.3 1.33e-8 Ileal carcinoids; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg12564285 chr5:131593104 PDLIM4 0.45 8.72 0.43 1.31e-16 Blood metabolite levels; LUSC cis rs2637266 0.935 rs2583058 chr10:78396018 T/A cg18941641 chr10:78392320 NA 0.42 7.51 0.38 5.51e-13 Pulmonary function; LUSC cis rs753778 1.000 rs753778 chr8:142228909 G/A cg18755752 chr8:142205143 DENND3 -0.52 -6.93 -0.35 2.22e-11 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg06819704 chr5:159707559 CCNJL 0.54 6.22 0.32 1.45e-9 Schizophrenia; LUSC cis rs936229 0.861 rs7162232 chr15:75115895 G/A cg10253484 chr15:75165896 SCAMP2 -0.49 -6.48 -0.33 3.26e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9467773 0.596 rs3001369 chr6:26670969 C/T cg11502198 chr6:26597334 ABT1 0.69 11.4 0.53 1.22e-25 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg08999081 chr20:33150536 PIGU 0.52 10.43 0.5 3.07e-22 Glomerular filtration rate (creatinine); LUSC cis rs9928842 0.824 rs889515 chr16:75251299 T/C cg09066997 chr16:75300724 BCAR1 0.54 6.4 0.33 5.34e-10 Alcoholic chronic pancreatitis; LUSC cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg15423357 chr2:25149977 NA 0.45 9.03 0.44 1.37e-17 Body mass index; LUSC cis rs4704187 0.617 rs6898134 chr5:74456731 T/C cg03227963 chr5:74354835 NA 0.31 6.86 0.35 3.34e-11 Response to amphetamines; LUSC cis rs6840360 0.571 rs4696272 chr4:152528229 A/G cg22705602 chr4:152727874 NA -0.33 -6.71 -0.34 8.54e-11 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -7.71 -0.39 1.43e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2224391 1.000 rs9784870 chr6:5261359 A/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.51 -7.33 -0.37 1.7e-12 Height; LUSC cis rs6977660 0.714 rs13230381 chr7:19833896 T/C cg07541023 chr7:19748670 TWISTNB 0.59 6.16 0.32 2.05e-9 Thyroid stimulating hormone; LUSC cis rs7197653 0.667 rs7190070 chr16:68353983 C/T cg05110241 chr16:68378359 PRMT7 -0.83 -8.92 -0.44 3.09e-17 Magnesium levels; LUSC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg11752832 chr7:134001865 SLC35B4 0.51 7.75 0.39 1.09e-13 Mean platelet volume; LUSC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.71e-13 Electroencephalogram traits; LUSC cis rs79387448 0.701 rs3752659 chr2:103001598 A/G cg09003973 chr2:102972529 NA 0.98 10.07 0.48 5.28e-21 Gut microbiota (bacterial taxa); LUSC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg23711669 chr6:146136114 FBXO30 -0.76 -12.0 -0.55 8.12e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg07157834 chr1:205819609 PM20D1 -0.73 -13.65 -0.6 5.16e-34 Monocyte percentage of white cells; LUSC cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs7569084 1.000 rs7569084 chr2:65656969 C/T cg08085232 chr2:65598271 SPRED2 0.38 5.8 0.3 1.52e-8 Sum eosinophil basophil counts; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg16031515 chr1:205743344 RAB7L1 -0.28 -6.11 -0.32 2.76e-9 Menarche (age at onset); LUSC trans rs8072100 0.967 rs8078880 chr17:45676526 G/C cg03886242 chr7:26192032 NFE2L3 0.37 6.25 0.32 1.22e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6964587 0.869 rs2023784 chr7:91524677 A/G cg22709100 chr7:91322751 NA -0.4 -5.84 -0.3 1.21e-8 Breast cancer; LUSC cis rs61931739 0.500 rs11513287 chr12:34584351 G/A cg06521331 chr12:34319734 NA -0.41 -6.35 -0.33 6.93e-10 Morning vs. evening chronotype; LUSC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg21285383 chr16:89894308 SPIRE2 0.36 7.85 0.39 5.77e-14 Vitiligo; LUSC cis rs10911232 0.507 rs35782443 chr1:183051502 A/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Hypertriglyceridemia; LUSC cis rs136211 0.640 rs9306310 chr22:36758258 G/A cg10790723 chr22:36903033 FOXRED2 0.4 5.86 0.31 1.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg17971929 chr21:40555470 PSMG1 -0.63 -10.39 -0.49 4.14e-22 Cognitive function; LUSC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg03060546 chr3:49711283 APEH 0.67 7.7 0.39 1.51e-13 Menarche (age at onset); LUSC cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.88 0.35 2.95e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -8.08 -0.4 1.18e-14 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7980799 0.967 rs7971226 chr12:33586881 C/T cg26384229 chr12:38710491 ALG10B 0.45 6.6 0.34 1.65e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg11645453 chr3:52864694 ITIH4 0.59 14.12 0.61 8.31e-36 Schizophrenia; LUSC cis rs861020 0.710 rs7516902 chr1:210022179 A/G cg09163369 chr1:210001066 C1orf107 0.59 6.86 0.35 3.28e-11 Orofacial clefts; LUSC trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs7647973 0.696 rs7100 chr3:49053219 A/G cg07636037 chr3:49044803 WDR6 0.92 12.01 0.55 7.51e-28 Menarche (age at onset); LUSC cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg00684032 chr4:1343700 KIAA1530 0.47 8.42 0.42 1.16e-15 Obesity-related traits; LUSC cis rs701145 0.938 rs242117 chr3:154026467 T/C cg17054900 chr3:154042577 DHX36 0.84 8.6 0.43 3.25e-16 Coronary artery disease; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.48 6.48 0.33 3.21e-10 Renal function-related traits (BUN); LUSC trans rs1998174 0.527 rs6685974 chr1:171837604 C/G cg13482142 chr2:234261155 NA 0.42 6.13 0.32 2.44e-9 Platelet distribution width; LUSC cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -7.63 -0.39 2.54e-13 Schizophrenia; LUSC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -8.15 -0.41 7.24e-15 Breast cancer; LUSC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg20203395 chr5:56204925 C5orf35 -0.46 -6.87 -0.35 3.14e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg02569458 chr12:86230093 RASSF9 0.52 8.66 0.43 2.05e-16 Major depressive disorder; LUSC cis rs9815354 0.767 rs115702638 chr3:42058594 C/T cg03022575 chr3:42003672 ULK4 0.59 6.33 0.33 8.03e-10 Pulse pressure;Diastolic blood pressure; LUSC trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg21775007 chr8:11205619 TDH -0.44 -6.51 -0.34 2.8e-10 Neuroticism; LUSC cis rs3093024 0.595 rs4458654 chr6:167476068 A/C cg25258033 chr6:167368657 RNASET2 0.45 6.87 0.35 3.17e-11 Rheumatoid arthritis; LUSC cis rs12928939 0.815 rs11648483 chr16:71707398 T/C cg03805757 chr16:71968109 PKD1L3 -0.39 -5.7 -0.3 2.68e-8 Post bronchodilator FEV1; LUSC trans rs1728785 1.000 rs8058314 chr16:68584151 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs7582720 0.943 rs72932556 chr2:203845996 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6785206 0.667 rs6439139 chr3:128410285 T/C cg16766828 chr3:128327626 NA -0.69 -7.62 -0.38 2.58e-13 Lymphocyte percentage of white cells; LUSC cis rs2637266 0.935 rs1978927 chr10:78399786 A/T cg18941641 chr10:78392320 NA 0.42 7.75 0.39 1.1e-13 Pulmonary function; LUSC cis rs6460942 0.591 rs4721078 chr7:12334657 T/A cg06484146 chr7:12443880 VWDE -0.56 -5.89 -0.31 9.39e-9 Coronary artery disease; LUSC cis rs3740713 1.000 rs73440615 chr11:18467283 T/C cg23797887 chr11:18477753 LDHAL6A -0.57 -6.8 -0.35 4.8e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs4555082 0.874 rs11622166 chr14:105759763 C/A cg27165867 chr14:105738592 BRF1 -0.54 -7.62 -0.39 2.57e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs34779708 0.966 rs35814343 chr10:35427714 G/T cg03585969 chr10:35415529 CREM 0.6 8.76 0.43 9.64e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11039100 0.850 rs12363853 chr11:5830163 G/A cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9303401 0.659 rs35564417 chr17:56718286 G/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.67 0.43 1.92e-16 Cognitive test performance; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12767885 chr10:134350658 INPP5A 0.64 6.02 0.31 4.57e-9 Cognitive performance; LUSC cis rs10986311 0.775 rs10986324 chr9:127121825 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.82 0.35 4.41e-11 Vitiligo; LUSC cis rs897984 0.574 rs11647284 chr16:31077335 G/A cg02466173 chr16:30829666 NA -0.48 -8.94 -0.44 2.8e-17 Dementia with Lewy bodies; LUSC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg03709012 chr19:19516395 GATAD2A 0.74 11.49 0.53 5.77e-26 Tonsillectomy; LUSC cis rs6087990 0.806 rs4911257 chr20:31359574 T/C cg13636640 chr20:31349939 DNMT3B 0.87 17.44 0.69 7.17e-49 Ulcerative colitis; LUSC cis rs9650315 0.733 rs11988714 chr8:57205891 A/T cg23139584 chr8:56987506 RPS20;SNORD54 -0.52 -6.76 -0.35 6.01e-11 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21561596 chr19:36239797 LIN37 0.41 5.96 0.31 6.27e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13089785 1.000 rs2271969 chr3:123650432 A/G cg19611163 chr3:123411211 MYLK 0.34 5.89 0.31 9.17e-9 Intelligence (multi-trait analysis); LUSC trans rs79976124 0.879 rs12213669 chr6:66627704 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 8.49 0.42 7.03e-16 Type 2 diabetes; LUSC cis rs2439831 0.702 rs28699233 chr15:44122866 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.78 6.66 0.34 1.13e-10 Lung cancer in ever smokers; LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg06263672 chr7:65235340 NA 0.41 5.93 0.31 7.57e-9 Calcium levels; LUSC trans rs1908814 0.516 rs7825529 chr8:11794444 C/T cg14343924 chr8:8086146 FLJ10661 0.44 6.11 0.32 2.77e-9 Neuroticism; LUSC cis rs1538970 0.962 rs2153607 chr1:45813820 G/A cg05343316 chr1:45956843 TESK2 0.59 8.23 0.41 4.24e-15 Platelet count; LUSC trans rs236907 0.859 rs2223602 chr1:171781735 C/T cg13482142 chr2:234261155 NA 0.51 6.21 0.32 1.61e-9 Mean platelet volume; LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23521916 chr3:48754752 IP6K2 0.55 6.18 0.32 1.9e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4631830 0.720 rs12412140 chr10:51503977 T/C cg10326726 chr10:51549505 MSMB 0.35 6.09 0.32 3.14e-9 Prostate-specific antigen levels; LUSC trans rs3749237 0.964 rs62260719 chr3:49852419 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.49 6.65 0.34 1.22e-10 Resting heart rate; LUSC cis rs2760061 0.583 rs708118 chr1:228201801 A/G cg18477163 chr1:228402036 OBSCN -0.52 -9.15 -0.45 5.8e-18 Diastolic blood pressure; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21936775 chr1:153607143 C1orf77;S100A13 0.44 6.73 0.35 7.46e-11 Triglycerides; LUSC cis rs1440410 0.835 rs7684847 chr4:144054567 C/T cg01719995 chr4:144104893 USP38 0.33 5.82 0.3 1.36e-8 Ischemic stroke; LUSC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg05340658 chr4:99064831 C4orf37 0.68 11.58 0.54 2.7e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs11252926 0.545 rs10466270 chr10:556129 A/G cg03684893 chr10:554711 DIP2C -0.45 -8.36 -0.42 1.77e-15 Psychosis in Alzheimer's disease; LUSC cis rs1348850 0.567 rs1405714 chr2:178538584 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.44 -6.08 -0.32 3.38e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs6582630 0.519 rs8189599 chr12:38280748 A/G cg06521331 chr12:34319734 NA -0.41 -6.36 -0.33 6.81e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs13031619 0.607 rs13011199 chr2:3694994 A/G cg10645314 chr2:3704589 ALLC 0.33 5.74 0.3 2.11e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg18350739 chr11:68623251 NA -0.39 -6.78 -0.35 5.47e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.69 -0.43 1.66e-16 Body mass index; LUSC cis rs3833788 1 rs3833788 chr12:121151062 CTCTCTTG/C cg27246729 chr12:121163418 ACADS 0.47 7.53 0.38 4.89e-13 Mean corpuscular hemoglobin; LUSC cis rs208520 0.661 rs704519 chr6:66801136 T/C cg07460842 chr6:66804631 NA -1.14 -18.24 -0.71 4.67e-52 Exhaled nitric oxide output; LUSC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg19052272 chr2:3704530 ALLC -0.46 -7.56 -0.38 4.04e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs950169 0.580 rs11630887 chr15:85193015 A/T cg17507749 chr15:85114479 UBE2QP1 0.59 7.51 0.38 5.37e-13 Schizophrenia; LUSC cis rs314370 1.000 rs10278546 chr7:100516003 G/T cg10426581 chr7:100472382 SRRT -0.7 -9.64 -0.47 1.41e-19 Resting heart rate; LUSC cis rs11048434 0.736 rs11048345 chr12:9123056 T/G cg13575925 chr12:9217583 LOC144571 0.34 6.22 0.32 1.46e-9 Sjögren's syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21904595 chr2:61991516 NA 0.44 6.27 0.32 1.09e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg18758796 chr5:131593413 PDLIM4 0.43 7.31 0.37 2.05e-12 Blood metabolite levels; LUSC cis rs2455601 1.000 rs56336128 chr11:8908299 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.6 -0.34 1.58e-10 Schizophrenia; LUSC cis rs807669 0.807 rs807431 chr22:19242361 G/A cg02655711 chr22:19163373 SLC25A1 0.74 14.58 0.62 1.34e-37 Metabolite levels; LUSC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg25767906 chr1:53392781 SCP2 -0.36 -6.1 -0.32 2.89e-9 Monocyte count; LUSC cis rs2249625 0.508 rs60020363 chr6:72844706 C/T cg18830697 chr6:72922368 RIMS1 0.38 7.59 0.38 3.18e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs9929218 0.906 rs4783565 chr16:68750190 G/A cg02972257 chr16:68554789 NA 0.45 5.94 0.31 7.05e-9 Colorectal cancer; LUSC cis rs9311676 0.656 rs4339119 chr3:58389462 A/G cg26110898 chr3:58419937 PDHB 0.4 6.49 0.33 3.05e-10 Systemic lupus erythematosus; LUSC cis rs76878669 0.561 rs10896112 chr11:66116836 G/C cg18002602 chr11:66138449 SLC29A2 -0.48 -8.43 -0.42 1.07e-15 Educational attainment (years of education); LUSC cis rs9311676 0.632 rs11130642 chr3:58420042 C/T cg13750441 chr3:58318267 PXK 0.35 6.83 0.35 4.14e-11 Systemic lupus erythematosus; LUSC cis rs6500602 1.000 rs12447826 chr16:4464617 T/C cg08645402 chr16:4508243 NA 0.54 9.26 0.45 2.61e-18 Schizophrenia; LUSC cis rs7122539 0.734 rs4930391 chr11:66645254 A/G cg18002602 chr11:66138449 SLC29A2 0.33 5.88 0.31 9.72e-9 HIV-1 susceptibility; LUSC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg18240062 chr17:79603768 NPLOC4 0.58 10.02 0.48 7.82e-21 Eye color traits; LUSC cis rs10504073 0.527 rs118032023 chr8:49926296 A/T cg00325661 chr8:49890786 NA 0.69 11.06 0.52 1.87e-24 Blood metabolite ratios; LUSC cis rs2070488 0.775 rs4679066 chr3:38568527 A/G cg24069376 chr3:38537580 EXOG -0.38 -7.46 -0.38 7.49e-13 Electrocardiographic conduction measures; LUSC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg13206674 chr6:150067644 NUP43 0.54 8.33 0.41 2.15e-15 Lung cancer; LUSC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg13319975 chr6:146136371 FBXO30 -0.68 -10.61 -0.5 7.21e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg23630131 chr7:65973040 NA 0.2 5.71 0.3 2.54e-8 Aortic root size; LUSC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg08847533 chr14:75593920 NEK9 -0.82 -14.74 -0.63 3.15e-38 Height; LUSC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg17366294 chr4:99064904 C4orf37 -0.57 -10.1 -0.48 4.21e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg18904891 chr8:8559673 CLDN23 0.6 8.13 0.41 8.6e-15 Obesity-related traits; LUSC cis rs66569888 0.789 rs66826026 chr2:106732879 C/T cg15412446 chr2:106886593 NA -0.5 -6.22 -0.32 1.47e-9 Facial morphology (factor 23); LUSC cis rs3791556 1.000 rs3791556 chr2:240112972 G/A cg03281426 chr2:240109471 HDAC4 0.49 5.93 0.31 7.53e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs859767 0.501 rs1568121 chr2:135406606 G/A cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Neuroticism; LUSC cis rs1997103 0.906 rs2177806 chr7:55402609 A/T cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs2243480 1.000 rs34136756 chr7:65381256 A/G cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC trans rs6076960 0.684 rs6054059 chr20:6262472 G/T cg21095983 chr6:86352623 SYNCRIP 0.53 8.46 0.42 8.29e-16 Smooth-surface caries; LUSC cis rs10986311 0.775 rs6478658 chr9:127127810 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.44 -7.21 -0.37 3.7e-12 Vitiligo; LUSC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg11657440 chr19:46296263 DMWD 0.87 16.29 0.67 2.48e-44 Coronary artery disease; LUSC cis rs11190604 1.000 rs7079756 chr10:102302105 G/A cg23241863 chr10:102295624 HIF1AN 0.46 5.76 0.3 1.92e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.46 0.38 7.73e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7106204 0.514 rs1596280 chr11:24250853 T/C ch.11.24196551F chr11:24239977 NA 0.91 10.09 0.48 4.56e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4947962 0.617 rs729969 chr7:55128207 C/T cg23757825 chr7:55092271 EGFR -0.51 -6.35 -0.33 6.97e-10 Subjective response to lithium treatment; LUSC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg16339924 chr4:17578868 LAP3 0.64 10.13 0.48 3.35e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1577917 1.000 rs12190604 chr6:86716215 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.69 -0.43 1.66e-16 Response to antipsychotic treatment; LUSC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.24 0.52 4.48e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg10623288 chr13:32421051 EEF1DP3 0.48 6.23 0.32 1.4e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 11.75 0.54 6.26e-27 Alzheimer's disease; LUSC cis rs17401966 0.838 rs946503 chr1:10308631 C/G cg19773385 chr1:10388646 KIF1B 0.53 9.08 0.44 9.77e-18 Hepatocellular carcinoma; LUSC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs4285028 0.747 rs3772126 chr3:121354583 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.92 -12.78 -0.57 1.0500000000000001e-30 Multiple sclerosis; LUSC cis rs7264396 0.563 rs2066066 chr20:34329359 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.26 -0.41 3.35e-15 Total cholesterol levels; LUSC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21659725 chr3:3221576 CRBN 0.88 18.29 0.71 2.92e-52 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.7 0.3 2.64e-8 Menopause (age at onset); LUSC cis rs9611519 0.964 rs2179744 chr22:41621714 G/A cg13813247 chr22:41461852 NA -0.34 -6.35 -0.33 7.09e-10 Neuroticism; LUSC cis rs11098499 0.754 rs34425882 chr4:120253177 G/A cg24375607 chr4:120327624 NA 0.75 12.08 0.55 4.2e-28 Corneal astigmatism; LUSC trans rs2204008 0.522 rs117743143 chr12:38030824 C/T cg06521331 chr12:34319734 NA -0.4 -6.3 -0.33 9.17e-10 Bladder cancer; LUSC cis rs467650 0.509 rs2545678 chr5:98000368 T/A cg03885343 chr5:98108198 RGMB 0.31 5.84 0.3 1.27e-8 Venous thromboembolism (SNP x SNP interaction); LUSC trans rs4729127 1.000 rs17166206 chr7:94004197 C/T cg20086523 chr13:52378287 DHRS12 0.56 6.38 0.33 6.03e-10 Intelligence; LUSC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg03161606 chr19:29218774 NA 0.61 9.03 0.44 1.38e-17 Methadone dose in opioid dependence; LUSC cis rs4654899 0.833 rs3816454 chr1:21191416 T/G cg01072550 chr1:21505969 NA 0.45 6.61 0.34 1.57e-10 Superior frontal gyrus grey matter volume; LUSC cis rs6700896 0.966 rs1938485 chr1:66082084 A/G cg04111102 chr1:66153794 NA 0.31 6.92 0.35 2.3e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7582180 0.629 rs11688285 chr2:100948054 A/C cg12002119 chr2:101014098 CHST10 0.35 5.8 0.3 1.53e-8 Intelligence (multi-trait analysis); LUSC cis rs66887589 0.807 rs13134517 chr4:120405262 G/A cg09307838 chr4:120376055 NA 0.48 7.2 0.37 4.07e-12 Diastolic blood pressure; LUSC cis rs701145 0.556 rs355764 chr3:154013480 A/T cg17054900 chr3:154042577 DHX36 0.44 5.76 0.3 1.95e-8 Coronary artery disease; LUSC cis rs7804356 1.000 rs13438514 chr7:26860688 C/T cg03456212 chr7:26904342 SKAP2 -0.52 -6.1 -0.32 2.92e-9 Type 1 diabetes; LUSC cis rs1375194 0.509 rs62150473 chr2:33822320 G/A cg04131969 chr2:33951647 MYADML -0.63 -8.81 -0.43 6.8e-17 Response to antidepressants in depression; LUSC cis rs7296418 0.961 rs4148863 chr12:123569375 A/G cg05973401 chr12:123451056 ABCB9 0.62 9.24 0.45 2.85e-18 Platelet count; LUSC cis rs9902453 0.817 rs7217961 chr17:28403112 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.84 -0.51 1.16e-23 Coffee consumption (cups per day); LUSC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 10.7 0.51 3.46e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs394563 0.601 rs439495 chr6:149793224 A/G cg07828024 chr6:149772892 ZC3H12D 0.4 7.99 0.4 2.24e-14 Dupuytren's disease; LUSC cis rs11758351 1.000 rs79264785 chr6:26194121 C/T cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg11905131 chr22:24372483 LOC391322 -0.58 -9.66 -0.47 1.27e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19023700 chr7:131012349 MKLN1 0.41 6.35 0.33 6.88e-10 Triglycerides; LUSC cis rs11098499 0.954 rs10014845 chr4:120301077 T/G cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC trans rs2243480 0.901 rs778693 chr7:65872345 T/G cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC trans rs208520 1.000 rs12191598 chr6:66983962 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg22920501 chr2:26401640 FAM59B -0.76 -10.62 -0.5 7.07e-23 Gut microbiome composition (summer); LUSC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.06e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6669919 0.553 rs12568639 chr1:211675300 G/A cg10512769 chr1:211675356 NA -0.29 -6.88 -0.35 3e-11 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs6569990 chr6:135365818 C/T cg24558204 chr6:135376177 HBS1L 0.57 8.77 0.43 9.11e-17 Red blood cell count; LUSC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg08132940 chr7:1081526 C7orf50 -0.52 -6.25 -0.32 1.25e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35883536 0.647 rs2783702 chr1:101040836 G/A cg06223162 chr1:101003688 GPR88 0.49 9.44 0.46 6.6e-19 Monocyte count; LUSC cis rs9457247 0.534 rs1130033 chr6:167385623 C/T cg23791538 chr6:167370224 RNASET2 -0.5 -8.3 -0.41 2.54e-15 Crohn's disease; LUSC cis rs1801251 1.000 rs7578299 chr2:233573469 G/T cg08000102 chr2:233561755 GIGYF2 0.69 11.52 0.53 4.47e-26 Coronary artery disease; LUSC cis rs7119 0.717 rs62009070 chr15:77817884 G/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.48 -0.33 3.3e-10 Type 2 diabetes; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs9788721 0.836 rs2656052 chr15:78740932 A/C cg18825076 chr15:78729989 IREB2 -0.6 -9.81 -0.47 3.86e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6500602 0.682 rs3761679 chr16:4457907 C/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.45 5.73 0.3 2.23e-8 Schizophrenia; LUSC cis rs9462027 0.628 rs7771778 chr6:34660324 C/T cg07306190 chr6:34760872 UHRF1BP1 0.35 6.26 0.32 1.19e-9 Systemic lupus erythematosus; LUSC cis rs500891 0.525 rs750386 chr6:84030692 G/A cg08257003 chr6:84140564 ME1 0.31 6.88 0.35 2.88e-11 Platelet-derived growth factor BB levels; LUSC cis rs7149337 0.805 rs4350491 chr14:51675798 A/G cg23942311 chr14:51606299 NA 0.48 10.63 0.5 6.41e-23 Cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02841941 chr3:152552615 P2RY1 0.46 6.41 0.33 4.86e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1461503 0.966 rs1461501 chr11:122844416 A/G cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg02951883 chr7:2050386 MAD1L1 -0.52 -9.07 -0.44 1e-17 Bipolar disorder and schizophrenia; LUSC trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg15704280 chr7:45808275 SEPT13 -0.43 -5.98 -0.31 5.63e-9 HDL cholesterol; LUSC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg06618935 chr21:46677482 NA -0.39 -7.79 -0.39 8.32e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.72 -10.3 -0.49 8.47e-22 Cognitive test performance; LUSC cis rs4919694 0.901 rs12264456 chr10:104830634 C/T cg04362960 chr10:104952993 NT5C2 1.18 13.92 0.61 4.83e-35 Arsenic metabolism; LUSC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg01191920 chr7:158217561 PTPRN2 -0.59 -12.38 -0.56 3.2e-29 Obesity-related traits; LUSC cis rs7824557 0.628 rs2572387 chr8:11204165 C/T cg21775007 chr8:11205619 TDH 0.83 13.73 0.6 2.58e-34 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.69 0.39 1.63e-13 Prudent dietary pattern; LUSC cis rs9925964 0.967 rs1978487 chr16:31129942 C/T cg03418659 chr16:31128414 MYST1 -0.39 -6.17 -0.32 2e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC trans rs1325195 0.520 rs2783389 chr1:179228396 G/A cg11624085 chr17:8464688 MYH10 0.45 6.89 0.35 2.77e-11 IgE grass sensitization; LUSC cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.9 0.35 2.56e-11 Rheumatoid arthritis; LUSC cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg24692254 chr21:30365293 RNF160 -0.54 -7.87 -0.4 5.06e-14 Dental caries; LUSC cis rs2548003 0.518 rs1833823 chr5:28741723 A/G cg22863700 chr5:28928346 NA 0.47 6.49 0.33 3.1e-10 Hip geometry; LUSC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg06462663 chr19:18546047 ISYNA1 0.46 7.85 0.39 5.53e-14 Breast cancer; LUSC cis rs9611565 0.571 rs2050032 chr22:42152429 C/T cg17376030 chr22:41985996 PMM1 -0.43 -5.67 -0.3 3.01e-8 Vitiligo; LUSC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg10523679 chr1:76189770 ACADM 0.83 11.47 0.53 6.46e-26 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7131987 0.650 rs7954871 chr12:29459732 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.72 -0.34 7.98e-11 QT interval; LUSC trans rs17685 0.753 rs1637044 chr7:75703744 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.57e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6599077 1.000 rs9822101 chr3:40095554 C/A cg13683864 chr3:40499215 RPL14 -0.6 -7.66 -0.39 2.06e-13 Sleep-related phenotypes; LUSC trans rs12439619 0.530 rs7162177 chr15:82474069 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.49 -7.86 -0.4 5.19e-14 Intelligence (multi-trait analysis); LUSC cis rs8099014 1.000 rs1806761 chr18:56132499 A/C cg12907477 chr18:56117327 MIR122 0.42 6.38 0.33 5.83e-10 Platelet count; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.63 0.39 2.49e-13 Bipolar disorder; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07918776 chr15:49170303 SHC4;EID1 -0.39 -6.26 -0.32 1.21e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.02 15.01 0.63 2.83e-39 Age-related macular degeneration (geographic atrophy); LUSC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg11984989 chr7:158649758 WDR60 0.96 19.64 0.73 1.2e-57 Height; LUSC cis rs9815354 0.597 rs59432762 chr3:41812294 G/C cg03022575 chr3:42003672 ULK4 0.85 8.67 0.43 1.87e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs888194 0.544 rs2196612 chr12:109849535 A/G cg19025524 chr12:109796872 NA -0.34 -5.85 -0.3 1.2e-8 Neuroticism; LUSC cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg13010199 chr12:38710504 ALG10B 0.71 12.23 0.56 1.14e-28 Heart rate; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg10862848 chr6:42927986 GNMT -0.28 -6.9 -0.35 2.69e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg00631329 chr6:26305371 NA 0.34 5.92 0.31 7.93e-9 Intelligence (multi-trait analysis); LUSC cis rs6545883 0.929 rs7561229 chr2:61737990 A/T cg15711740 chr2:61764176 XPO1 -0.5 -7.94 -0.4 3.11e-14 Tuberculosis; LUSC cis rs9807841 0.592 rs10407349 chr19:10758453 G/A cg17710535 chr19:10819994 QTRT1 0.42 6.8 0.35 4.91e-11 Inflammatory skin disease; LUSC cis rs16854884 0.586 rs4613453 chr3:143735600 C/G cg06585982 chr3:143692056 C3orf58 0.51 8.17 0.41 6.38e-15 Economic and political preferences (feminism/equality); LUSC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg06481639 chr22:41940642 POLR3H 0.48 5.87 0.31 1.05e-8 Vitiligo; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24113505 chr7:92861286 CCDC132 0.37 6.18 0.32 1.83e-9 Triglycerides; LUSC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg05313129 chr8:58192883 C8orf71 -0.51 -6.64 -0.34 1.26e-10 Developmental language disorder (linguistic errors); LUSC cis rs6696846 0.791 rs10158848 chr1:205061192 C/T cg21545522 chr1:205238299 TMCC2 0.47 8.6 0.43 3.09e-16 Red blood cell count; LUSC cis rs13191362 0.507 rs13210000 chr6:163176944 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.34 6.14 0.32 2.31e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs61931739 0.534 rs10844816 chr12:34248533 C/A cg26384229 chr12:38710491 ALG10B 0.73 11.93 0.55 1.42e-27 Morning vs. evening chronotype; LUSC cis rs2230307 0.536 rs6677998 chr1:100461046 G/A cg24955406 chr1:100503596 HIAT1 0.56 6.04 0.31 4.01e-9 Carotid intima media thickness; LUSC cis rs2729354 0.729 rs2581923 chr11:57249991 C/T cg24343310 chr11:57249947 NA 0.44 8.5 0.42 6.55e-16 Blood protein levels; LUSC cis rs6469656 0.772 rs2118108 chr8:117654773 G/T cg24004040 chr8:117650383 NA -0.43 -6.33 -0.33 8.11e-10 Colorectal cancer; LUSC cis rs2274273 0.840 rs10467798 chr14:55724927 C/T cg04306507 chr14:55594613 LGALS3 0.56 13.15 0.58 3.92e-32 Protein biomarker; LUSC cis rs713477 0.967 rs10483642 chr14:55920460 A/G cg13175173 chr14:55914753 NA 0.29 6.11 0.32 2.7e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs1003719 0.680 rs3737540 chr21:38523266 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.3 -0.49 8.95e-22 Eye color traits; LUSC cis rs2108225 0.872 rs6980029 chr7:107446127 T/C cg18560240 chr7:107437656 SLC26A3 -0.44 -6.53 -0.34 2.42e-10 Ulcerative colitis; LUSC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.77 0.39 9.83e-14 Blood metabolite levels; LUSC cis rs6701037 1.000 rs12747817 chr1:175118895 C/T cg17845761 chr1:175162550 KIAA0040 -0.33 -6.31 -0.33 8.83e-10 Alcohol dependence; LUSC cis rs1670533 1.000 rs629260 chr4:1086764 A/G cg27284194 chr4:1044797 NA 0.6 9.01 0.44 1.61e-17 Recombination rate (females); LUSC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 7.89e-25 Mean corpuscular volume; LUSC cis rs62408225 1.000 rs62408222 chr6:90948476 A/G cg06866423 chr6:90926672 BACH2 0.4 5.75 0.3 2.01e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs870825 0.698 rs72703549 chr4:185623963 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs7833986 1.000 rs34404111 chr8:57099190 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.63 9.35 0.46 1.28e-18 Height; LUSC cis rs6736093 0.932 rs17174697 chr2:112662914 A/G cg12686935 chr2:112915763 FBLN7 -0.37 -5.83 -0.3 1.34e-8 Coronary artery disease; LUSC cis rs7215564 0.818 rs112155856 chr17:78594573 A/T cg23238734 chr17:78661607 RPTOR 0.49 6.34 0.33 7.35e-10 Myopia (pathological); LUSC cis rs950776 0.616 rs3743077 chr15:78894896 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.57 0.34 1.97e-10 Sudden cardiac arrest; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg12419862 chr22:24373484 LOC391322 -0.95 -17.32 -0.69 1.99e-48 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs4751006 0.649 rs76125285 chr10:128779647 C/T cg05702161 chr10:128779687 DOCK1 -0.79 -6.68 -0.34 9.75e-11 Colonoscopy-negative controls vs population controls; LUSC trans rs6502050 0.835 rs4789737 chr17:80123269 G/A cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg26912877 chr1:6305344 HES3 0.43 6.66 0.34 1.14e-10 N-glycan levels; LUSC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg08219700 chr8:58056026 NA -0.66 -7.87 -0.4 5.15e-14 Developmental language disorder (linguistic errors); LUSC cis rs7220711 0.967 rs4793022 chr17:41798855 C/G cg26893861 chr17:41843967 DUSP3 0.43 6.01 0.31 4.8e-9 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg17366294 chr4:99064904 C4orf37 0.58 10.38 0.49 4.47e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2708377 0.860 rs2600347 chr12:11267880 G/A cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg13206674 chr6:150067644 NUP43 0.62 10.17 0.49 2.43e-21 Lung cancer; LUSC cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.52 0.65 2.69e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg12219531 chr12:120966889 COQ5 0.59 7.83 0.39 6.5e-14 High light scatter reticulocyte count; LUSC cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.85 -0.35 3.49e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC cis rs12681288 0.676 rs1562921 chr8:1021986 G/T cg04851639 chr8:1020857 NA -0.38 -7.97 -0.4 2.57e-14 Schizophrenia; LUSC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg15848620 chr12:58087721 OS9 0.45 5.74 0.3 2.18e-8 Multiple sclerosis; LUSC cis rs25645 0.502 rs8065126 chr17:38099035 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.56 9.25 0.45 2.81e-18 Myeloid white cell count; LUSC cis rs2857891 0.817 rs2857902 chr11:6980256 C/G cg04053776 chr11:6947353 ZNF215 0.41 5.69 0.3 2.73e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs6163 0.588 rs10786706 chr10:104500659 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.54 -0.34 2.34e-10 Waist circumference;Hip circumference; LUSC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg06544989 chr22:39130855 UNC84B 0.33 5.67 0.3 3.02e-8 Menopause (age at onset); LUSC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg00745463 chr17:30367425 LRRC37B -0.79 -9.22 -0.45 3.42e-18 Hip circumference adjusted for BMI; LUSC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg05253716 chr12:129299332 SLC15A4;MGC16384 0.43 6.31 0.33 8.8e-10 Systemic lupus erythematosus; LUSC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg08439880 chr3:133502540 NA -0.34 -6.04 -0.31 4.09e-9 Iron status biomarkers; LUSC cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14442939 chr10:27389572 ANKRD26 0.84 9.84 0.47 3.2e-20 Breast cancer; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg18844144 chr14:23528430 ACIN1 -0.38 -6.25 -0.32 1.24e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs3803170 0.513 rs10774623 chr12:111833589 C/T cg10833066 chr12:111807467 FAM109A -0.39 -7.32 -0.37 1.9e-12 Mean corpuscular hemoglobin; LUSC cis rs7188861 0.681 rs34947566 chr16:11412926 C/A cg00044050 chr16:11439710 C16orf75 0.59 6.08 0.32 3.22e-9 HDL cholesterol; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.3 -5.69 -0.3 2.85e-8 Lymphocyte counts; LUSC trans rs12043259 0.730 rs12044625 chr1:204794737 T/G cg05134015 chr14:36973365 SFTA3 -0.5 -6.04 -0.31 4.05e-9 Addiction; LUSC cis rs41271473 1.000 rs11583565 chr1:228880135 C/T cg10167378 chr1:228756711 NA 0.54 6.59 0.34 1.72e-10 Chronic lymphocytic leukemia; LUSC cis rs9640161 0.830 rs17173702 chr7:150068605 G/A cg17279839 chr7:150038598 RARRES2 0.39 5.86 0.31 1.12e-8 Blood protein levels;Circulating chemerin levels; LUSC trans rs4729127 1.000 rs12665908 chr7:94010770 T/C cg20086523 chr13:52378287 DHRS12 0.54 6.31 0.33 9.11e-10 Intelligence; LUSC cis rs3784262 0.904 rs12901462 chr15:58316487 A/G cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.93 -0.31 7.5e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08038078 chr1:160002094 PIGM 0.44 6.36 0.33 6.62e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs804280 0.542 rs36100659 chr8:11791653 A/T cg06636001 chr8:8085503 FLJ10661 0.55 8.15 0.41 7.55e-15 Myopia (pathological); LUSC trans rs6502050 0.835 rs8067138 chr17:80111026 T/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg24562669 chr7:97807699 LMTK2 0.36 6.29 0.33 9.85e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg12292205 chr6:26970375 C6orf41 0.41 6.18 0.32 1.88e-9 Intelligence (multi-trait analysis); LUSC cis rs6484504 0.576 rs58702363 chr11:31246397 C/A cg26647111 chr11:31128758 NA -0.4 -5.75 -0.3 1.99e-8 Red blood cell count; LUSC trans rs75804782 0.641 rs72985397 chr2:239341354 A/G cg01134436 chr17:81009848 B3GNTL1 0.63 6.13 0.32 2.55e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.63 0.47 1.62e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6840360 0.837 rs13137669 chr4:152710943 A/G cg22705602 chr4:152727874 NA -0.27 -5.9 -0.31 8.98e-9 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg04414720 chr1:150670196 GOLPH3L 0.51 8.11 0.41 9.78e-15 Melanoma; LUSC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg00409905 chr10:38381863 ZNF37A -0.36 -6.21 -0.32 1.57e-9 Extrinsic epigenetic age acceleration; LUSC cis rs9398803 0.865 rs1538171 chr6:126752884 C/G cg19875578 chr6:126661172 C6orf173 0.41 5.96 0.31 6.26e-9 Male-pattern baldness; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg07092213 chr7:1199455 ZFAND2A -0.54 -8.93 -0.44 3.01e-17 Longevity;Endometriosis; LUSC trans rs984440 0.524 rs6577869 chr8:139083777 C/A cg03334052 chr1:168888044 NA 0.39 6.47 0.33 3.52e-10 Obesity-related traits; LUSC cis rs7598759 0.712 rs6727510 chr2:232332016 T/C cg19187155 chr2:232395269 NMUR1 0.49 7.2 0.37 3.96e-12 Noise-induced hearing loss; LUSC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg07701084 chr6:150067640 NUP43 0.56 8.39 0.42 1.36e-15 Lung cancer; LUSC cis rs1009647 0.529 rs56098354 chr14:55668170 G/T cg04306507 chr14:55594613 LGALS3 0.45 6.12 0.32 2.67e-9 Testicular germ cell tumor; LUSC cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg23649088 chr2:200775458 C2orf69 0.51 6.94 0.35 2.05e-11 Schizophrenia; LUSC cis rs11098499 0.691 rs2136911 chr4:120265859 G/A cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.4e-19 Corneal astigmatism; LUSC cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.66 0.57 2.91e-30 Menopause (age at onset); LUSC cis rs7712401 0.791 rs1870559 chr5:122116706 G/C cg19077854 chr5:122220652 SNX24 0.35 7.87 0.4 5.01e-14 Mean platelet volume; LUSC cis rs826838 0.510 rs17523988 chr12:39222785 A/C cg13010199 chr12:38710504 ALG10B 0.62 9.14 0.45 6.27e-18 Heart rate; LUSC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg10523679 chr1:76189770 ACADM -0.84 -12.91 -0.58 3.37e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg25643088 chr3:52874325 TMEM110 0.39 5.78 0.3 1.71e-8 Schizophrenia; LUSC cis rs9303401 0.527 rs7224468 chr17:56749943 C/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.11 0.41 9.88e-15 Cognitive test performance; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg10150615 chr22:24372951 LOC391322 -0.34 -5.88 -0.31 9.96e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3126085 0.935 rs1858480 chr1:152301735 A/G cg03465714 chr1:152285911 FLG 0.4 5.72 0.3 2.34e-8 Atopic dermatitis; LUSC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg12311346 chr5:56204834 C5orf35 -0.92 -13.6 -0.6 7.64e-34 Initial pursuit acceleration; LUSC cis rs2295359 1.000 rs963427 chr1:67609347 A/G cg17031739 chr1:67600172 NA 0.38 5.84 0.3 1.23e-8 Psoriasis; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6500395 1.000 rs1004909 chr16:48725580 C/G cg04672837 chr16:48644449 N4BP1 -0.46 -6.88 -0.35 3e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6062509 0.965 rs2315007 chr20:62343845 T/C cg21849932 chr20:62369462 LIME1 -0.41 -6.1 -0.32 2.94e-9 Prostate cancer; LUSC cis rs6882046 0.533 rs599402 chr5:88043656 G/C cg22951263 chr5:87985283 NA -0.47 -7.81 -0.39 7.54e-14 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg25456477 chr12:86230367 RASSF9 0.43 7.8 0.39 8.24e-14 Major depressive disorder; LUSC cis rs12579753 1.000 rs11115047 chr12:82232773 C/G cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs912057 0.833 rs1024245 chr6:6743319 A/G cg06612196 chr6:6737390 NA 0.55 10.47 0.5 2.33e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs4808199 0.947 rs4808960 chr19:19574277 G/C cg03709012 chr19:19516395 GATAD2A 1.1 14.57 0.62 1.44e-37 Nonalcoholic fatty liver disease; LUSC cis rs1595825 0.891 rs59617443 chr2:198653204 C/A cg00982548 chr2:198649783 BOLL -0.58 -7.21 -0.37 3.87e-12 Ulcerative colitis; LUSC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg07741184 chr6:167504864 NA 0.37 6.64 0.34 1.25e-10 Crohn's disease; LUSC cis rs1577917 0.682 rs1173417 chr6:86403941 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 9.46 0.46 5.69e-19 Response to antipsychotic treatment; LUSC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg16545954 chr1:2118288 C1orf86 0.31 5.9 0.31 8.83e-9 Height; LUSC cis rs6696846 0.777 rs9651228 chr1:205049383 A/G cg21643547 chr1:205240462 TMCC2 -0.38 -7.02 -0.36 1.24e-11 Red blood cell count; LUSC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg21724239 chr8:58056113 NA 0.57 6.53 0.34 2.39e-10 Developmental language disorder (linguistic errors); LUSC cis rs17125944 0.505 rs10483618 chr14:53203590 T/C cg00686598 chr14:53173677 PSMC6 1.13 10.29 0.49 9.55e-22 Alzheimer's disease (late onset); LUSC trans rs1814175 0.817 rs12290508 chr11:49621037 C/T cg15704280 chr7:45808275 SEPT13 -1.11 -23.51 -0.79 8.21e-73 Height; LUSC cis rs4889911 0.544 rs1285273 chr17:77830885 A/G cg00646381 chr17:77835854 NA 0.6 9.75 0.47 6.38e-20 Electroencephalogram traits; LUSC cis rs7539409 0.833 rs2057083 chr1:84269942 T/G cg10977910 chr1:84465055 TTLL7 0.64 6.08 0.32 3.33e-9 Alzheimer's disease; LUSC cis rs11167764 1.000 rs6887599 chr5:141484349 G/A cg23435118 chr5:141488016 NDFIP1 -0.56 -7.77 -0.39 9.49e-14 Crohn's disease; LUSC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg09034736 chr1:150693464 HORMAD1 0.44 5.93 0.31 7.74e-9 Urate levels; LUSC cis rs2486288 0.656 rs11639420 chr15:45559268 A/C cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.5 -0.5 1.72e-22 Glomerular filtration rate; LUSC cis rs9640161 0.783 rs35435439 chr7:150063534 C/T cg21361702 chr7:150065534 REPIN1 0.59 8.25 0.41 3.77e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg07701084 chr6:150067640 NUP43 0.54 8.08 0.4 1.17e-14 Lung cancer; LUSC cis rs478304 0.654 rs6591185 chr11:65455742 A/G cg27068330 chr11:65405492 SIPA1 -0.74 -10.3 -0.49 8.46e-22 Acne (severe); LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.58 7.38 0.37 1.24e-12 Renal function-related traits (BUN); LUSC trans rs208520 0.754 rs851594 chr6:66876695 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -16.25 -0.66 3.52e-44 Exhaled nitric oxide output; LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg16405210 chr4:1374714 KIAA1530 -0.85 -13.94 -0.61 3.89e-35 Longevity; LUSC cis rs6424115 0.867 rs34902309 chr1:24192200 A/G cg15997130 chr1:24165203 NA -0.51 -8.24 -0.41 4.03e-15 Immature fraction of reticulocytes; LUSC cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg00071950 chr4:10020882 SLC2A9 -0.52 -8.72 -0.43 1.34e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1908814 0.510 rs57655799 chr8:11782417 A/C cg00405596 chr8:11794950 NA 0.35 5.83 0.3 1.3e-8 Neuroticism; LUSC cis rs500891 0.533 rs6454328 chr6:84171230 A/G cg08257003 chr6:84140564 ME1 0.35 8.67 0.43 1.87e-16 Platelet-derived growth factor BB levels; LUSC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg00484396 chr16:3507460 NAT15 -0.45 -7.51 -0.38 5.39e-13 Body mass index (adult); LUSC cis rs12681287 0.640 rs7460342 chr8:87475137 C/T cg27223183 chr8:87520930 FAM82B -0.54 -7.44 -0.38 8.39e-13 Caudate activity during reward; LUSC cis rs7267979 1.000 rs448396 chr20:25440269 G/A cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.9 -0.31 8.91e-9 Intelligence (multi-trait analysis); LUSC trans rs7615952 0.641 rs4490307 chr3:125712676 T/G cg07211511 chr3:129823064 LOC729375 -0.83 -11.9 -0.55 1.86e-27 Blood pressure (smoking interaction); LUSC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg04414720 chr1:150670196 GOLPH3L 0.5 7.76 0.39 1.03e-13 Melanoma; LUSC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg03517284 chr6:25882590 NA -0.46 -7.86 -0.39 5.47e-14 Intelligence (multi-trait analysis); LUSC cis rs939574 1.000 rs7574937 chr2:220099331 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.07 8.71 0.43 1.42e-16 Platelet distribution width; LUSC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg23205692 chr1:25664452 TMEM50A 0.43 6.42 0.33 4.78e-10 Erythrocyte sedimentation rate; LUSC cis rs1577917 0.739 rs2758846 chr6:86349570 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.92 -0.44 3.02e-17 Response to antipsychotic treatment; LUSC cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg01765077 chr12:122356316 WDR66 0.54 7.69 0.39 1.66e-13 Mean corpuscular volume; LUSC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg17173187 chr15:85201210 NMB 0.37 6.52 0.34 2.64e-10 Schizophrenia; LUSC cis rs2228479 0.681 rs7196840 chr16:89959647 A/G cg26513180 chr16:89883248 FANCA 0.61 5.84 0.3 1.22e-8 Skin colour saturation; LUSC cis rs7954584 0.616 rs10743186 chr12:122356436 C/T cg01765077 chr12:122356316 WDR66 0.49 6.73 0.35 7.54e-11 Mean corpuscular volume; LUSC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC cis rs9300255 0.602 rs1716172 chr12:123712712 G/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.94 -0.31 7.31e-9 Neutrophil percentage of white cells; LUSC cis rs9814567 1.000 rs2056604 chr3:134312648 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg09033563 chr22:24373618 LOC391322 -0.48 -6.77 -0.35 5.86e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7980799 0.682 rs10844612 chr12:33603676 T/C cg13010199 chr12:38710504 ALG10B -0.44 -6.46 -0.33 3.74e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg02569458 chr12:86230093 RASSF9 -0.49 -8.25 -0.41 3.64e-15 Major depressive disorder; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg18301423 chr5:131593218 PDLIM4 0.48 7.44 0.38 8.77e-13 Acylcarnitine levels; LUSC cis rs12449964 0.524 rs4925094 chr17:17569012 C/T cg09796270 chr17:17721594 SREBF1 -0.41 -7.24 -0.37 3.15e-12 Coronary artery disease or ischemic stroke; LUSC cis rs11051970 0.879 rs2171373 chr12:32575777 C/T cg02745156 chr12:32552066 NA 0.43 7.33 0.37 1.73e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6469656 0.892 rs12547058 chr8:117663147 C/G cg24004040 chr8:117650383 NA -0.42 -6.26 -0.32 1.16e-9 Colorectal cancer; LUSC trans rs502716 1.000 rs518281 chr20:926325 T/C cg25252482 chr7:119893751 NA -0.33 -6.01 -0.31 4.96e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs7727544 0.716 rs7701414 chr5:131585958 A/G cg09877947 chr5:131593287 PDLIM4 0.41 6.83 0.35 4.08e-11 Blood metabolite levels; LUSC trans rs4625783 0.583 rs11077974 chr17:80095193 A/G cg07393940 chr7:158741817 NA 0.37 6.78 0.35 5.58e-11 Blood metabolite levels; LUSC cis rs1865721 1.000 rs8096298 chr18:73187608 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -7.93 -0.4 3.27e-14 Intelligence; LUSC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg20476274 chr7:133979776 SLC35B4 0.88 16.9 0.68 1.01e-46 Mean platelet volume; LUSC trans rs2243480 1.000 rs313809 chr7:65499983 G/A cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.58e-15 Diabetic kidney disease; LUSC cis rs3733585 0.648 rs67820465 chr4:9975873 A/G cg00071950 chr4:10020882 SLC2A9 -0.53 -8.78 -0.43 8.34e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg04518342 chr5:131593106 PDLIM4 0.42 7.47 0.38 7.23e-13 Breast cancer; LUSC cis rs709400 0.628 rs1951392 chr14:103853367 T/G cg10523860 chr14:103875565 MARK3 -0.38 -6.03 -0.31 4.39e-9 Body mass index; LUSC cis rs637571 0.528 rs566266 chr11:65573587 A/C cg26695010 chr11:65641043 EFEMP2 0.46 6.68 0.34 1.02e-10 Eosinophil percentage of white cells; LUSC cis rs5769707 0.642 rs135880 chr22:50018654 T/A cg20744362 chr22:50050164 C22orf34 0.38 7.32 0.37 1.87e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2625529 0.713 rs12903980 chr15:72165549 C/T cg16672083 chr15:72433130 SENP8 -0.5 -7.27 -0.37 2.57e-12 Red blood cell count; LUSC cis rs7799006 0.527 rs6967286 chr7:2212758 C/A cg04267008 chr7:1944627 MAD1L1 -0.42 -6.13 -0.32 2.55e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs208520 1.000 rs72880045 chr6:66965232 A/C cg07460842 chr6:66804631 NA 0.96 12.45 0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.02 0.52 2.69e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6942756 1.000 rs2141075 chr7:128877305 C/T cg02491457 chr7:128862824 NA 0.54 7.78 0.39 8.96e-14 White matter hyperintensity burden; LUSC trans rs2926702 0.810 rs11993276 chr8:71095359 A/G cg13462967 chr19:40396032 FCGBP -0.47 -6.03 -0.31 4.37e-9 Non-small cell lung cancer; LUSC trans rs2786098 0.656 rs12025476 chr1:197525439 A/C cg16005942 chr6:160526640 IGF2R 0.51 6.03 0.31 4.34e-9 Asthma; LUSC cis rs2204008 0.805 rs4882575 chr12:37940573 G/A cg13010199 chr12:38710504 ALG10B -0.63 -9.71 -0.47 8.5e-20 Bladder cancer; LUSC cis rs7712401 0.715 rs385996 chr5:122355228 T/G cg19077854 chr5:122220652 SNX24 -0.41 -8.71 -0.43 1.45e-16 Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01932091 chr1:29213675 EPB41 0.45 6.28 0.32 1.04e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg20476274 chr7:133979776 SLC35B4 0.85 16.26 0.66 3.22e-44 Mean platelet volume; LUSC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg16405210 chr4:1374714 KIAA1530 -0.5 -7.3 -0.37 2.13e-12 Obesity-related traits; LUSC cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg13010199 chr12:38710504 ALG10B -0.58 -9.17 -0.45 5.12e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs6545883 0.860 rs6545848 chr2:61461183 G/T cg15711740 chr2:61764176 XPO1 0.43 6.77 0.35 5.88e-11 Tuberculosis; LUSC cis rs13315871 1.000 rs9844128 chr3:58391127 C/T cg20936604 chr3:58311152 NA -0.67 -6.29 -0.33 9.73e-10 Cholesterol, total; LUSC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg16680214 chr1:154839983 KCNN3 -0.53 -10.07 -0.48 5.2e-21 Prostate cancer; LUSC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg03676636 chr4:99064102 C4orf37 0.33 7.16 0.36 5.04e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg02951883 chr7:2050386 MAD1L1 -0.44 -7.7 -0.39 1.52e-13 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.954 rs6849171 chr4:120409549 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.5 0.34 2.87e-10 Corneal astigmatism; LUSC cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg23583168 chr7:148888333 NA -0.85 -14.83 -0.63 1.36e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6084875 0.840 rs2065704 chr20:4719344 A/T cg07258627 chr20:4721683 PRNT -0.34 -6.06 -0.31 3.75e-9 Systemic lupus erythematosus; LUSC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg11494091 chr17:61959527 GH2 -0.38 -6.69 -0.34 9.69e-11 Height; LUSC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg14019146 chr3:50243930 SLC38A3 -0.36 -8.2 -0.41 5.14e-15 Body mass index; LUSC cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg22676075 chr6:135203613 NA 0.58 9.12 0.45 7.32e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg27535305 chr1:53392650 SCP2 0.32 5.85 0.3 1.19e-8 Monocyte count; LUSC cis rs10871290 0.650 rs12600126 chr16:74489732 A/T cg01733217 chr16:74700730 RFWD3 -0.64 -9.78 -0.47 5.03e-20 Breast cancer; LUSC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.93 0.31 7.75e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7587476 0.862 rs13001462 chr2:215678346 G/A cg04004882 chr2:215674386 BARD1 0.48 6.38 0.33 5.89e-10 Neuroblastoma; LUSC cis rs9486719 1.000 rs2472886 chr6:96864876 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs4363385 0.747 rs9919276 chr1:152968654 A/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.5 -0.38 5.93e-13 Inflammatory skin disease; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.6 -0.34 1.66e-10 Calcium levels; LUSC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg11764359 chr7:65958608 NA -0.63 -9.73 -0.47 7.23e-20 Aortic root size; LUSC cis rs782590 0.967 rs782592 chr2:55843875 T/A cg18811423 chr2:55921094 PNPT1 0.66 10.14 0.49 3.14e-21 Metabolic syndrome; LUSC trans rs9886428 1.000 rs1427024 chr8:14119015 G/A cg11959399 chr20:741723 C20orf54 -0.4 -6.28 -0.32 1.05e-9 IgG glycosylation; LUSC cis rs920590 0.527 rs79929516 chr8:19650050 G/C cg01411142 chr8:19674711 INTS10 0.5 5.66 0.3 3.31e-8 Acute lymphoblastic leukemia (childhood); LUSC trans rs1448094 0.817 rs10863108 chr12:86328249 C/T cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs9303401 0.734 rs8073316 chr17:57211381 A/T cg10487724 chr17:56770010 TEX14;RAD51C -0.51 -7.83 -0.39 6.75e-14 Cognitive test performance; LUSC cis rs244293 0.760 rs8069447 chr17:53008873 A/C cg19360675 chr17:53046073 COX11;STXBP4 -0.42 -6.31 -0.33 8.9e-10 Menarche (age at onset); LUSC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg13939156 chr17:80058883 NA 0.33 6.45 0.33 4.03e-10 Life satisfaction; LUSC cis rs11971779 0.680 rs6962186 chr7:139034806 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.25 0.32 1.25e-9 Diisocyanate-induced asthma; LUSC cis rs2070488 0.736 rs2070988 chr3:38437835 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 11.78 0.54 4.8400000000000004e-27 Electrocardiographic conduction measures; LUSC cis rs7312933 0.618 rs6582394 chr12:42686189 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.77 0.35 5.78e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs477692 0.583 rs2008387 chr10:131448764 C/T cg05714579 chr10:131428358 MGMT -0.81 -13.06 -0.58 9e-32 Response to temozolomide; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03008165 chr11:77024667 NA 0.54 6.76 0.35 6.08e-11 Bipolar disorder and schizophrenia; LUSC cis rs9549367 0.826 rs9549710 chr13:113898064 A/C cg00898013 chr13:113819073 PROZ -0.55 -7.87 -0.4 5.12e-14 Platelet distribution width; LUSC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg09998033 chr7:158218633 PTPRN2 -0.5 -8.12 -0.41 9.2e-15 Obesity-related traits; LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs2294693 0.853 rs9296350 chr6:40977623 G/A cg14769373 chr6:40998127 UNC5CL -0.45 -6.53 -0.34 2.51e-10 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7178572 1.000 rs2055901 chr15:77759295 G/A cg22256960 chr15:77711686 NA -0.54 -9.05 -0.44 1.22e-17 Type 2 diabetes; LUSC trans rs2950393 0.804 rs2958132 chr12:57144533 C/G cg14367344 chr1:146644336 PRKAB2 -0.42 -6.02 -0.31 4.61e-9 Platelet distribution width; LUSC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg06640241 chr16:89574553 SPG7 0.72 11.64 0.54 1.66e-26 Multiple myeloma (IgH translocation); LUSC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg18225595 chr11:63971243 STIP1 0.48 5.79 0.3 1.66e-8 Mean platelet volume; LUSC cis rs58235267 0.553 rs11890276 chr2:63366191 C/T cg17519650 chr2:63277830 OTX1 0.72 10.51 0.5 1.71e-22 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg12257692 chr3:49977190 RBM6 -0.25 -7.14 -0.36 5.84e-12 Body mass index; LUSC cis rs1577917 0.876 rs12190735 chr6:86686467 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.56 -0.34 2.09e-10 Response to antipsychotic treatment; LUSC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg06238570 chr21:40685208 BRWD1 -0.53 -8.16 -0.41 6.76e-15 Menarche (age at onset); LUSC cis rs12519773 1.000 rs6880789 chr5:92451777 A/G cg18783429 chr5:92414398 NA 0.29 6.38 0.33 6.07e-10 Migraine; LUSC cis rs965604 1.000 rs8043227 chr15:78768871 C/G cg18825076 chr15:78729989 IREB2 -0.44 -7.14 -0.36 5.9e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg17264618 chr3:40429014 ENTPD3 0.34 6.91 0.35 2.52e-11 Renal cell carcinoma; LUSC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg12751644 chr20:60527061 NA -0.33 -5.89 -0.31 9.2e-9 Body mass index; LUSC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg03690763 chr11:133734501 NA -0.32 -5.93 -0.31 7.64e-9 Childhood ear infection; LUSC cis rs7605827 0.930 rs7595512 chr2:15678368 C/T cg19274914 chr2:15703543 NA 0.47 9.03 0.44 1.43e-17 Educational attainment (years of education); LUSC cis rs117623576 0.618 rs211413 chr10:32396902 C/A cg03047570 chr10:32398778 NA 0.5 5.68 0.3 2.98e-8 Anti-saccade response; LUSC cis rs1775715 1.000 rs1775715 chr10:32309005 A/G cg18675610 chr10:32216311 ARHGAP12 -0.27 -5.71 -0.3 2.5e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg01256987 chr12:42539512 GXYLT1 -0.46 -8.81 -0.43 6.81e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7264396 1.000 rs224424 chr20:34147998 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -7.38 -0.37 1.28e-12 Total cholesterol levels; LUSC trans rs11039798 1.000 rs12225599 chr11:48755868 T/C cg15704280 chr7:45808275 SEPT13 0.81 7.73 0.39 1.27e-13 Axial length; LUSC cis rs6704644 0.719 rs3768801 chr2:234373702 G/A cg05711037 chr2:234359783 DGKD 0.66 6.42 0.33 4.75e-10 Bilirubin levels; LUSC cis rs9372498 0.572 rs56082110 chr6:118909480 A/G cg18833306 chr6:118973337 C6orf204 -0.46 -5.83 -0.3 1.34e-8 Diastolic blood pressure; LUSC cis rs10761482 0.861 rs1380458 chr10:62107690 A/T cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg04267008 chr7:1944627 MAD1L1 0.5 7.51 0.38 5.34e-13 Bipolar disorder and schizophrenia; LUSC cis rs4700695 0.719 rs27588 chr5:65459360 C/A cg21114390 chr5:65439923 SFRS12 -0.63 -8.98 -0.44 2.07e-17 Facial morphology (factor 19); LUSC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg00484396 chr16:3507460 NAT15 0.5 7.42 0.38 9.71e-13 Body mass index (adult); LUSC cis rs11098499 0.754 rs1849457 chr4:120254355 A/G cg24375607 chr4:120327624 NA 0.77 12.49 0.56 1.24e-29 Corneal astigmatism; LUSC cis rs920590 0.796 rs10788700 chr8:19635098 T/C cg03894339 chr8:19674705 INTS10 0.42 5.66 0.3 3.21e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg06022373 chr22:39101656 GTPBP1 0.88 14.45 0.62 4.3e-37 Menopause (age at onset); LUSC cis rs7772486 0.875 rs2748485 chr6:146332421 T/C cg05347473 chr6:146136440 FBXO30 0.52 8.89 0.44 3.99e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg11812906 chr14:75593930 NEK9 -0.64 -10.54 -0.5 1.25e-22 Height; LUSC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg14061069 chr19:46274453 DMPK 0.68 13.89 0.61 6.07e-35 Coronary artery disease; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg06877462 chr1:205807181 PM20D1 0.52 9.33 0.45 1.5e-18 Menarche (age at onset); LUSC cis rs12681288 0.550 rs7000482 chr8:958380 T/C cg15309053 chr8:964076 NA 0.4 8.23 0.41 4.34e-15 Schizophrenia; LUSC cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg20283391 chr11:68216788 NA -0.58 -8.24 -0.41 3.96e-15 Total body bone mineral density; LUSC trans rs62055045 0.528 rs7194638 chr16:71573818 A/G cg21834679 chr15:96891026 NA -0.37 -6.05 -0.31 3.97e-9 Schizophrenia; LUSC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg10802521 chr3:52805072 NEK4 -0.58 -9.44 -0.46 6.75e-19 Electroencephalogram traits; LUSC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.86 0.31 1.09e-8 Menopause (age at onset); LUSC cis rs6542838 0.702 rs4851177 chr2:99535188 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.17 -0.32 1.93e-9 Fear of minor pain; LUSC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg05805236 chr11:65401703 PCNXL3 -0.38 -5.83 -0.3 1.27e-8 Breast cancer; LUSC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg22535103 chr8:58192502 C8orf71 -0.63 -7.06 -0.36 9.52e-12 Developmental language disorder (linguistic errors); LUSC cis rs10761482 0.813 rs10509130 chr10:62121112 C/T cg18175470 chr10:62150864 ANK3 -0.53 -7.44 -0.38 8.57e-13 Schizophrenia; LUSC cis rs853679 0.607 rs13199772 chr6:27834085 A/G cg26958806 chr6:27640298 NA 0.83 6.57 0.34 1.94e-10 Depression; LUSC cis rs2933343 0.729 rs789231 chr3:128602847 A/G cg11901034 chr3:128598214 ACAD9 -0.4 -6.17 -0.32 1.95e-9 IgG glycosylation; LUSC cis rs12618769 0.597 rs3754893 chr2:99063149 T/A cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs12493885 0.725 rs4680113 chr3:153727337 C/T cg17054900 chr3:154042577 DHX36 -0.58 -6.17 -0.32 1.93e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs7613875 0.620 rs2526747 chr3:50082914 C/G cg21659725 chr3:3221576 CRBN 0.56 9.21 0.45 3.66e-18 Body mass index; LUSC cis rs9650657 0.547 rs11250099 chr8:10818657 C/T cg21775007 chr8:11205619 TDH 0.48 6.93 0.35 2.18e-11 Neuroticism; LUSC cis rs1775715 0.651 rs2808033 chr10:32194127 A/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.22 0.32 1.49e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2070488 0.775 rs2051213 chr3:38560254 C/T cg24069376 chr3:38537580 EXOG 0.4 7.85 0.39 5.55e-14 Electrocardiographic conduction measures; LUSC cis rs870825 0.860 rs2705886 chr4:185608591 T/C cg04058563 chr4:185651563 MLF1IP -0.75 -10.22 -0.49 1.67e-21 Blood protein levels; LUSC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg16545954 chr1:2118288 C1orf86 0.33 6.22 0.32 1.5e-9 Height; LUSC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg13206674 chr6:150067644 NUP43 0.52 7.93 0.4 3.42e-14 Lung cancer; LUSC cis rs9616064 0.531 rs17821649 chr22:47050387 G/A cg05621596 chr22:47072043 GRAMD4 -0.54 -8.62 -0.43 2.75e-16 Urate levels in obese individuals; LUSC cis rs6752107 0.967 rs10210302 chr2:234158839 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.71 11.92 0.55 1.57e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7561273 0.586 rs116650625 chr2:24353212 C/G cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs2050392 0.517 rs603072 chr10:30755778 C/T cg18806716 chr10:30721971 MAP3K8 0.62 9.9 0.48 2.02e-20 Inflammatory bowel disease; LUSC cis rs2398893 0.924 rs7047684 chr9:96792790 C/T cg14459158 chr9:96720562 NA 0.29 5.68 0.3 2.92e-8 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9650657 0.529 rs10108618 chr8:10953092 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.28 -0.32 1.06e-9 Neuroticism; LUSC cis rs7772486 0.806 rs4243478 chr6:146284560 A/G cg05347473 chr6:146136440 FBXO30 -0.49 -8.36 -0.42 1.7e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs11864453 0.826 rs2074626 chr16:72139184 C/A cg23815491 chr16:72088622 HP 0.35 6.14 0.32 2.34e-9 Fibrinogen levels; LUSC cis rs6469656 1.000 rs4289846 chr8:117651368 A/C cg24004040 chr8:117650383 NA -0.43 -6.22 -0.32 1.46e-9 Colorectal cancer; LUSC cis rs9534288 0.830 rs940 chr13:46627480 C/G cg15192986 chr13:46630673 CPB2 -0.79 -13.02 -0.58 1.22e-31 Blood protein levels; LUSC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg25072359 chr17:41440525 NA 0.59 8.52 0.42 5.62e-16 Menopause (age at onset); LUSC cis rs2439831 0.681 rs478104 chr15:43594900 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.09 15.58 0.65 1.59e-41 Lung cancer in ever smokers; LUSC cis rs427394 0.772 rs274689 chr5:6736215 G/C cg10857441 chr5:6722123 POLS -0.46 -8.94 -0.44 2.7e-17 Menopause (age at onset); LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg16405210 chr4:1374714 KIAA1530 -0.56 -8.61 -0.43 3.02e-16 Obesity-related traits; LUSC cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg09184832 chr6:79620586 NA -0.44 -7.18 -0.37 4.66e-12 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.18 0.77 1.27e-67 Prudent dietary pattern; LUSC cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.18 -0.37 4.56e-12 Bipolar disorder; LUSC cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.44 -6.73 -0.35 7.59e-11 Colorectal cancer; LUSC cis rs7582180 0.700 rs2309852 chr2:100982527 T/C cg12002119 chr2:101014098 CHST10 0.35 5.76 0.3 1.89e-8 Intelligence (multi-trait analysis); LUSC cis rs10992471 0.603 rs7872610 chr9:95299137 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -6.97 -0.36 1.7e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg18404041 chr3:52824283 ITIH1 -0.56 -9.51 -0.46 3.92e-19 Schizophrenia; LUSC cis rs2580764 0.598 rs6726158 chr2:55239202 G/T cg20993754 chr2:55226987 RTN4 0.36 6.06 0.31 3.59e-9 Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17308661 chr14:57857235 NAA30 0.44 6.4 0.33 5.23e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg18230493 chr5:56204884 C5orf35 -0.86 -12.98 -0.58 1.85e-31 Initial pursuit acceleration; LUSC cis rs4343996 0.558 rs1554498 chr7:3415568 A/G cg21248987 chr7:3385318 SDK1 0.36 6.12 0.32 2.59e-9 Motion sickness; LUSC cis rs7937682 0.575 rs7114617 chr11:111768173 A/T cg09085632 chr11:111637200 PPP2R1B 0.96 13.3 0.59 1.14e-32 Primary sclerosing cholangitis; LUSC cis rs62103177 0.535 rs4799109 chr18:77675188 A/T cg20368463 chr18:77673604 PQLC1 0.69 6.75 0.35 6.41e-11 Opioid sensitivity; LUSC cis rs9283706 0.595 rs1115252 chr5:66322741 A/G cg11590213 chr5:66331682 MAST4 0.45 6.96 0.36 1.81e-11 Coronary artery disease; LUSC cis rs6582630 0.512 rs11182667 chr12:38588392 C/A cg13010199 chr12:38710504 ALG10B -0.45 -6.75 -0.35 6.64e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs1355223 0.525 rs55796371 chr11:34872769 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.74 -0.35 7e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg04455712 chr21:45112962 RRP1B 0.44 8.19 0.41 5.68e-15 Mean corpuscular volume; LUSC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg11764359 chr7:65958608 NA -0.7 -10.83 -0.51 1.31e-23 Aortic root size; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.69 10.43 0.5 2.99e-22 Lymphocyte counts; LUSC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg12751644 chr20:60527061 NA -0.34 -6.16 -0.32 2.07e-9 Body mass index; LUSC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.72 -0.39 1.4e-13 Aortic root size; LUSC cis rs11048434 0.736 rs2377674 chr12:9112761 A/G cg04155231 chr12:9217510 LOC144571 0.3 5.7 0.3 2.67e-8 Sjögren's syndrome; LUSC cis rs1483890 1.000 rs1483890 chr3:69410725 A/G cg22125112 chr3:69402811 FRMD4B 0.38 5.65 0.3 3.46e-8 Resting heart rate; LUSC trans rs2243480 1.000 rs2961102 chr7:65424658 A/G cg10756647 chr7:56101905 PSPH 0.86 8.36 0.42 1.7e-15 Diabetic kidney disease; LUSC cis rs10193935 0.901 rs6724626 chr2:42689757 C/G cg27598129 chr2:42591480 NA 0.62 7.95 0.4 2.94e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10078 0.559 rs2037077 chr5:447226 A/G cg08916839 chr5:415575 AHRR 0.73 7.0 0.36 1.4e-11 Fat distribution (HIV); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg05310920 chr2:150186634 LYPD6 0.47 6.05 0.31 3.8e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10992471 0.756 rs2516568 chr9:95187380 A/T cg14631576 chr9:95140430 CENPP -0.31 -5.68 -0.3 2.97e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs8014204 0.747 rs2070598 chr14:75360906 C/T cg08847533 chr14:75593920 NEK9 -0.42 -6.09 -0.32 3.19e-9 Caffeine consumption; LUSC cis rs3008870 0.536 rs2208576 chr1:67513401 C/G cg02640540 chr1:67518911 SLC35D1 -0.53 -7.82 -0.39 6.85e-14 Lymphocyte percentage of white cells; LUSC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg03709012 chr19:19516395 GATAD2A 0.85 14.47 0.62 3.69e-37 Tonsillectomy; LUSC cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg00071950 chr4:10020882 SLC2A9 -0.58 -9.55 -0.46 2.92e-19 Bone mineral density; LUSC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg20243544 chr17:37824526 PNMT 0.39 5.96 0.31 6.59e-9 Self-reported allergy; LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg10117171 chr1:25599238 RHD -0.37 -5.7 -0.3 2.68e-8 Erythrocyte sedimentation rate; LUSC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg22431228 chr1:16359049 CLCNKA -0.51 -10.18 -0.49 2.27e-21 Dilated cardiomyopathy; LUSC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs9467773 0.967 rs9461267 chr6:26525455 T/G cg11502198 chr6:26597334 ABT1 0.59 9.3 0.45 1.85e-18 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg26441486 chr22:50317300 CRELD2 0.46 6.67 0.34 1.05e-10 Schizophrenia; LUSC cis rs9788682 0.748 rs637137 chr15:78873976 T/A cg24631222 chr15:78858424 CHRNA5 0.68 9.11 0.45 7.54e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1113500 0.524 rs11185270 chr1:108654362 G/A cg06207961 chr1:108661230 NA 0.34 5.82 0.3 1.4e-8 Growth-regulated protein alpha levels; LUSC cis rs4891159 0.790 rs72975929 chr18:74144630 G/C cg24786174 chr18:74118243 ZNF516 -0.85 -16.07 -0.66 1.93e-43 Longevity; LUSC trans rs7829975 0.846 rs11779061 chr8:8549432 G/A cg27411982 chr8:10470053 RP1L1 -0.41 -6.28 -0.32 1.07e-9 Mood instability; LUSC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg25208724 chr1:156163844 SLC25A44 1.11 27.31 0.83 4.24e-87 Testicular germ cell tumor; LUSC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21659725 chr3:3221576 CRBN -0.88 -17.9 -0.7 1.02e-50 Intelligence (multi-trait analysis); LUSC cis rs9467773 1.000 rs10946835 chr6:26533757 C/T cg05738196 chr6:26577821 NA 0.82 15.82 0.65 1.9e-42 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg04287289 chr16:89883240 FANCA 0.79 14.0 0.61 2.4e-35 Vitiligo; LUSC cis rs11758351 1.000 rs11755210 chr6:26202768 C/T cg01420254 chr6:26195488 NA 0.72 7.48 0.38 6.52e-13 Gout;Renal underexcretion gout; LUSC cis rs72634258 0.945 rs441597 chr1:8080895 A/G cg00042356 chr1:8021962 PARK7 0.64 8.47 0.42 7.79e-16 Inflammatory bowel disease; LUSC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg00933542 chr6:150070202 PCMT1 0.32 6.67 0.34 1.08e-10 Lung cancer; LUSC cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg16339924 chr4:17578868 LAP3 0.63 9.87 0.48 2.51e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4332037 0.539 rs11764590 chr7:2032803 C/T cg25206134 chr2:45395956 NA 0.61 6.98 0.36 1.55e-11 Bipolar disorder; LUSC cis rs72781680 1.000 rs72798408 chr2:24181845 G/C cg20701182 chr2:24300061 SF3B14 0.77 7.74 0.39 1.17e-13 Lymphocyte counts; LUSC cis rs6669072 0.739 rs712026 chr1:91251381 T/C cg08895590 chr1:91227319 NA 0.28 5.86 0.31 1.09e-8 Cognitive function; LUSC cis rs7618501 1.000 rs2271960 chr3:49878078 A/G cg24110177 chr3:50126178 RBM5 -0.43 -6.79 -0.35 5.18e-11 Intelligence (multi-trait analysis); LUSC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg17252645 chr8:143867129 LY6D -0.34 -5.7 -0.3 2.61e-8 Urinary tract infection frequency; LUSC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg01879757 chr17:41196368 BRCA1 -0.46 -7.1 -0.36 7.39e-12 Menopause (age at onset); LUSC cis rs2742417 1.000 rs2742438 chr3:45743390 G/T cg09608765 chr3:45636137 LIMD1 -0.38 -7.5 -0.38 5.91e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg00409905 chr10:38381863 ZNF37A 0.34 5.81 0.3 1.44e-8 Extrinsic epigenetic age acceleration; LUSC cis rs10791097 0.694 rs10894275 chr11:130756251 C/T cg12179176 chr11:130786555 SNX19 0.85 14.78 0.63 2.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7264396 0.832 rs224361 chr20:34061578 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -5.96 -0.31 6.35e-9 Total cholesterol levels; LUSC cis rs3740540 0.530 rs2362503 chr10:126290538 T/C cg04949429 chr10:126290192 LHPP 0.37 7.77 0.39 9.52e-14 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg16524733 chr11:117070046 TAGLN 0.42 7.5 0.38 5.92e-13 Blood protein levels; LUSC cis rs540254 0.551 rs12143580 chr1:160790918 G/C cg20255094 chr1:160771763 LY9 0.57 6.92 0.35 2.31e-11 Blood protein levels; LUSC cis rs4243830 0.850 rs10779790 chr1:6608435 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.84 -10.09 -0.48 4.69e-21 Body mass index; LUSC cis rs2439831 0.681 rs2278859 chr15:43632960 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.59 0.5 8.78e-23 Lung cancer in ever smokers; LUSC cis rs2204008 0.840 rs7957966 chr12:37953629 A/G cg26384229 chr12:38710491 ALG10B -0.81 -13.42 -0.59 4.02e-33 Bladder cancer; LUSC cis rs4906332 1.000 rs8012127 chr14:103942762 G/A cg04998671 chr14:104000505 TRMT61A -0.45 -7.15 -0.36 5.46e-12 Coronary artery disease; LUSC trans rs11992162 0.967 rs10112888 chr8:11830208 G/C cg08975724 chr8:8085496 FLJ10661 0.51 7.24 0.37 3.09e-12 Monocyte count; LUSC cis rs35771425 0.626 rs55761812 chr1:211653935 C/T cg10512769 chr1:211675356 NA -0.27 -5.93 -0.31 7.77e-9 Educational attainment (years of education); LUSC cis rs57221529 0.766 rs12519469 chr5:581772 A/G cg14541582 chr5:601475 NA -0.37 -5.87 -0.31 1.08e-8 Lung disease severity in cystic fibrosis; LUSC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg11211951 chr8:145729740 GPT -0.55 -10.71 -0.51 3.29e-23 Age at first birth; LUSC cis rs6430585 0.528 rs309133 chr2:136751842 A/C cg07169764 chr2:136633963 MCM6 1.02 15.22 0.64 4.28e-40 Corneal structure; LUSC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg04352962 chr1:209979756 IRF6 0.55 6.35 0.33 6.97e-10 Cleft lip with or without cleft palate; LUSC cis rs9788682 0.747 rs2568488 chr15:78736593 T/A cg18825076 chr15:78729989 IREB2 -0.47 -6.45 -0.33 3.93e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs11610422 1.000 rs12823902 chr12:31414290 A/G cg02734259 chr12:9559402 NA -0.59 -6.35 -0.33 7.09e-10 Coronary artery disease; LUSC cis rs9914988 1.000 rs9916866 chr17:27183155 C/G cg09479241 chr17:27052676 TLCD1 -0.4 -5.69 -0.3 2.85e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs7824557 0.564 rs2736304 chr8:11236964 C/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.5 -0.34 2.93e-10 Retinal vascular caliber; LUSC trans rs35110281 0.712 rs167930 chr21:44946625 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.94 0.48 1.4e-20 Mean corpuscular volume; LUSC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg10802521 chr3:52805072 NEK4 -0.54 -8.77 -0.43 9.05e-17 Bipolar disorder; LUSC cis rs6426558 0.537 rs2813950 chr1:227426072 A/G cg10327440 chr1:227177885 CDC42BPA -0.53 -7.32 -0.37 1.88e-12 Neutrophil percentage of white cells; LUSC cis rs478304 0.651 rs78412025 chr11:65495696 T/C cg10518572 chr11:65560635 OVOL1 -0.25 -5.75 -0.3 1.97e-8 Acne (severe); LUSC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg15147215 chr3:52552868 STAB1 -0.29 -5.83 -0.3 1.28e-8 Bipolar disorder; LUSC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg24531977 chr5:56204891 C5orf35 -1.05 -15.45 -0.65 5.46e-41 Initial pursuit acceleration; LUSC cis rs13242816 1.000 rs56250718 chr7:116103303 A/G cg16553024 chr7:116138462 CAV2 -0.53 -5.81 -0.3 1.46e-8 P wave duration; LUSC cis rs372883 0.967 rs2832292 chr21:30738760 C/A cg08807101 chr21:30365312 RNF160 0.43 6.24 0.32 1.35e-9 Pancreatic cancer; LUSC cis rs9527 0.590 rs10786741 chr10:104939182 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.51 0.46 3.99e-19 Arsenic metabolism; LUSC cis rs7759001 0.817 rs10080814 chr6:27362874 T/G cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs10197940 0.550 rs77233070 chr2:152416477 G/A cg19508488 chr2:152266495 RIF1 0.51 6.89 0.35 2.82e-11 Lung cancer; LUSC cis rs9399135 0.904 rs4895438 chr6:135317665 G/T cg22676075 chr6:135203613 NA 0.48 7.61 0.38 2.8e-13 Red blood cell count; LUSC cis rs483180 0.859 rs478093 chr1:120255126 C/T cg19096424 chr1:120255104 PHGDH -0.6 -8.54 -0.42 4.92e-16 Macular telangiectasia type 2; LUSC cis rs2898681 0.521 rs6833350 chr4:53740868 A/G cg00791764 chr4:53727839 RASL11B 0.48 6.39 0.33 5.59e-10 Optic nerve measurement (cup area); LUSC cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg21573476 chr21:45109991 RRP1B -0.41 -6.82 -0.35 4.2e-11 Mean corpuscular volume; LUSC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg21963583 chr11:68658836 MRPL21 0.55 7.95 0.4 2.98e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg23630131 chr7:65973040 NA 0.21 5.78 0.3 1.74e-8 Aortic root size; LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.48 6.92 0.35 2.26e-11 Renal function-related traits (BUN); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02706205 chr15:49447933 GALK2;COPS2 0.39 5.99 0.31 5.39e-9 Triglycerides; LUSC cis rs79057730 0.599 rs6951032 chr7:794092 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.79 7.73 0.39 1.29e-13 Initial pursuit acceleration; LUSC cis rs5758511 0.731 rs58302269 chr22:42351309 G/A cg12850546 chr22:42539477 CYP2D7P1 -0.49 -6.02 -0.31 4.5e-9 Birth weight; LUSC cis rs3862030 0.839 rs2281880 chr10:104269217 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -9.93 -0.48 1.52e-20 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg00431813 chr7:1051703 C7orf50 -0.42 -6.65 -0.34 1.23e-10 Longevity;Endometriosis; LUSC cis rs1577917 0.839 rs12664634 chr6:86579414 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg19046167 chr17:80928561 B3GNTL1 0.46 7.57 0.38 3.75e-13 Breast cancer; LUSC cis rs6840360 0.571 rs4696271 chr4:152509118 G/A cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.58e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12701220 0.690 rs10243973 chr7:1064983 T/C cg00990874 chr7:1149470 C7orf50 -0.44 -5.76 -0.3 1.86e-8 Bronchopulmonary dysplasia; LUSC cis rs66887589 0.616 rs7659403 chr4:120207254 T/A cg24375607 chr4:120327624 NA 0.5 7.73 0.39 1.31e-13 Diastolic blood pressure; LUSC cis rs7043114 0.525 rs7853859 chr9:95151377 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.69 -0.34 9.6e-11 Height; LUSC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg17971929 chr21:40555470 PSMG1 -0.74 -12.79 -0.57 9.25e-31 Cognitive function; LUSC cis rs11098499 0.954 rs1480931 chr4:120395809 G/T cg09307838 chr4:120376055 NA 0.76 11.22 0.52 5.12e-25 Corneal astigmatism; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg06877462 chr1:205807181 PM20D1 0.5 8.93 0.44 2.8e-17 Menarche (age at onset); LUSC cis rs4363385 0.719 rs6587714 chr1:152933023 T/C cg00922841 chr1:152955080 SPRR1A -0.43 -6.98 -0.36 1.56e-11 Inflammatory skin disease; LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg01616529 chr11:638424 DRD4 -0.35 -6.02 -0.31 4.64e-9 Systemic lupus erythematosus; LUSC cis rs1008375 1.000 rs3815414 chr4:17606659 A/G cg16339924 chr4:17578868 LAP3 -0.58 -9.01 -0.44 1.63e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg08219700 chr8:58056026 NA 0.66 8.16 0.41 6.98e-15 Developmental language disorder (linguistic errors); LUSC trans rs208520 0.874 rs208470 chr6:66916402 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -14.11 -0.61 8.76e-36 Exhaled nitric oxide output; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg27588902 chr6:42928151 GNMT -0.29 -6.54 -0.34 2.34e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs68170813 0.523 rs3757713 chr7:107042750 A/C cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.65 -0.3 3.4e-8 Coronary artery disease; LUSC cis rs2281845 0.929 rs2057579 chr1:201099275 T/C cg22815214 chr1:201083145 CACNA1S 0.58 9.9 0.48 1.94e-20 Permanent tooth development; LUSC cis rs9527 0.590 rs7901197 chr10:104840433 C/T cg23093090 chr10:104574429 C10orf26 -0.38 -6.93 -0.35 2.14e-11 Arsenic metabolism; LUSC trans rs10506458 1.000 rs12425655 chr12:63434463 C/T cg22491629 chr6:157744540 C6orf35 -0.79 -9.9 -0.48 1.98e-20 Hemostatic factors and hematological phenotypes; LUSC cis rs394563 0.601 rs431978 chr6:149793000 C/T cg11245181 chr6:149772854 ZC3H12D 0.3 5.86 0.31 1.11e-8 Dupuytren's disease; LUSC cis rs9640161 0.659 rs7781827 chr7:150008858 T/C cg27494647 chr7:150038898 RARRES2 0.46 7.09 0.36 8.27e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs56283067 0.578 rs12211510 chr6:45361189 A/G cg18551225 chr6:44695536 NA -0.42 -6.35 -0.33 6.91e-10 Total body bone mineral density; LUSC cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.6 0.65 1.31e-41 Bladder cancer; LUSC cis rs73206853 0.841 rs7297096 chr12:110798322 G/C cg12870014 chr12:110450643 ANKRD13A 0.68 6.43 0.33 4.37e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9473147 0.543 rs4711878 chr6:47456118 A/G cg12968598 chr6:47444699 CD2AP 0.53 7.99 0.4 2.22e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg06494592 chr3:125709126 NA -0.5 -6.14 -0.32 2.36e-9 Blood pressure (smoking interaction); LUSC cis rs1580019 0.961 rs958217 chr7:32493417 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.85 0.54 2.71e-27 Cognitive ability; LUSC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg06740227 chr12:86229804 RASSF9 0.44 7.05 0.36 1.03e-11 Major depressive disorder; LUSC cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg24112000 chr20:60950667 NA -0.34 -6.5 -0.34 2.91e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs35306767 0.623 rs34034003 chr10:1143435 G/A cg20503657 chr10:835505 NA 0.52 6.27 0.32 1.12e-9 Eosinophil percentage of granulocytes; LUSC cis rs934734 0.563 rs11673987 chr2:65597671 A/G cg08085232 chr2:65598271 SPRED2 -0.45 -6.9 -0.35 2.62e-11 Rheumatoid arthritis; LUSC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg07343612 chr16:622815 PIGQ -0.71 -11.97 -0.55 1.01e-27 Height; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg27284194 chr4:1044797 NA 0.38 6.51 0.34 2.73e-10 Obesity-related traits; LUSC cis rs12044355 0.827 rs11586191 chr1:231831781 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 5.84 0.3 1.26e-8 Alzheimer's disease; LUSC cis rs3774830 0.534 rs7687596 chr4:5472092 C/T cg26943120 chr4:5472116 STK32B -0.4 -8.64 -0.43 2.31e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4594175 1.000 rs4594175 chr14:51606541 C/A cg23942311 chr14:51606299 NA 0.31 5.9 0.31 8.82e-9 Cancer; LUSC cis rs6424115 0.830 rs3003335 chr1:24200052 A/G cg15997130 chr1:24165203 NA 0.52 8.54 0.42 4.67e-16 Immature fraction of reticulocytes; LUSC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11890956 chr21:40555474 PSMG1 1.04 20.84 0.75 2.29e-62 Cognitive function; LUSC cis rs75557865 1 rs75557865 chr3:121652141 G/A cg11130432 chr3:121712080 ILDR1 0.41 6.97 0.36 1.72e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7937682 0.961 rs7119563 chr11:111543916 T/A cg22437258 chr11:111473054 SIK2 -0.48 -6.21 -0.32 1.56e-9 Primary sclerosing cholangitis; LUSC cis rs6546550 0.835 rs13002091 chr2:70118388 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.46 -0.38 7.68e-13 Prevalent atrial fibrillation; LUSC trans rs72674100 1.000 rs7671134 chr4:97990088 A/G cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs71435601 0.515 rs486246 chr2:21406751 G/A cg20757404 chr19:378427 NA 0.37 5.98 0.31 5.75e-9 Cholesterol, total; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg07806771 chr7:64541737 NA -0.47 -6.69 -0.34 9.65e-11 Calcium levels; LUSC cis rs12980942 1.000 rs3826714 chr19:41825776 A/G cg25627403 chr19:41769009 HNRNPUL1 0.57 6.15 0.32 2.17e-9 Coronary artery disease; LUSC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg24642844 chr7:1081250 C7orf50 -0.68 -9.44 -0.46 6.82e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg02711726 chr17:80685570 FN3KRP -0.41 -6.26 -0.32 1.18e-9 Glycated hemoglobin levels; LUSC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg22862634 chr11:62369728 EML3;MTA2 0.59 9.25 0.45 2.83e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg11645453 chr3:52864694 ITIH4 0.35 8.2 0.41 5.41e-15 Bipolar disorder; LUSC cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg04455712 chr21:45112962 RRP1B -0.48 -8.98 -0.44 2.06e-17 Mean corpuscular volume; LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC cis rs12912251 1.000 rs12916379 chr15:38991520 A/G cg01338139 chr15:38987640 C15orf53 -0.49 -6.8 -0.35 4.75e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs2262909 1.000 rs2175366 chr19:22128279 C/T cg11619707 chr19:22235551 ZNF257 -0.39 -5.72 -0.3 2.32e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs11958404 0.929 rs79656592 chr5:157430291 G/A cg05962755 chr5:157440814 NA 0.55 6.27 0.32 1.11e-9 IgG glycosylation; LUSC cis rs10752881 1.000 rs10797808 chr1:182979623 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 3.05e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.1 0.36 7.55e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6938 0.534 rs59945415 chr15:75228427 C/A cg03289416 chr15:75166202 SCAMP2 0.43 6.61 0.34 1.56e-10 Breast cancer; LUSC cis rs367615 0.537 rs17161729 chr5:108660528 C/G cg17395555 chr5:108820864 NA -0.52 -9.28 -0.45 2.24e-18 Colorectal cancer (SNP x SNP interaction); LUSC cis rs6964587 1.000 rs7789492 chr7:91668854 C/T cg17063962 chr7:91808500 NA 0.57 9.09 0.45 8.73e-18 Breast cancer; LUSC cis rs9811920 0.732 rs7613864 chr3:99602470 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 6.57 0.34 1.89e-10 Axial length; LUSC cis rs62400317 0.826 rs12194682 chr6:45320520 T/A cg20913747 chr6:44695427 NA -0.47 -7.74 -0.39 1.18e-13 Total body bone mineral density; LUSC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg24690094 chr11:67383802 NA 0.43 8.31 0.41 2.36e-15 Mean corpuscular volume; LUSC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.37 0.49 5.04e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.47 -7.12 -0.36 6.79e-12 Colorectal cancer; LUSC cis rs7264396 0.561 rs6060750 chr20:34596371 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.54 -7.69 -0.39 1.7e-13 Total cholesterol levels; LUSC cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg08085267 chr17:45401833 C17orf57 -0.6 -9.97 -0.48 1.12e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg04234412 chr22:24373322 LOC391322 -0.86 -14.01 -0.61 2.2e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs73206853 0.764 rs55991901 chr12:110962702 C/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 7.83e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs259282 0.602 rs194589 chr19:33144621 T/C cg22980127 chr19:33182716 NUDT19 -0.42 -5.69 -0.3 2.77e-8 Schizophrenia; LUSC cis rs9811920 0.665 rs1872609 chr3:99906579 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -6.39 -0.33 5.63e-10 Axial length; LUSC cis rs1030268 0.546 rs12707100 chr7:133274376 T/C cg10665199 chr7:133106180 EXOC4 0.61 6.83 0.35 4.12e-11 Intelligence (multi-trait analysis); LUSC cis rs6580649 0.941 rs4760615 chr12:48428150 A/G cg24011408 chr12:48396354 COL2A1 0.51 6.83 0.35 4.11e-11 Lung cancer; LUSC cis rs897984 0.647 rs8060857 chr16:31002720 G/A cg02466173 chr16:30829666 NA 0.57 10.91 0.51 6.45e-24 Dementia with Lewy bodies; LUSC cis rs6060717 0.536 rs11696912 chr20:34497660 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.56 5.8 0.3 1.55e-8 Hip circumference adjusted for BMI; LUSC cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg26384229 chr12:38710491 ALG10B 0.96 18.57 0.71 2.27e-53 Heart rate; LUSC cis rs7561273 0.586 rs7589717 chr2:24357463 G/A cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs2050392 1.000 rs2253585 chr10:30696503 C/T cg18806716 chr10:30721971 MAP3K8 -0.46 -7.44 -0.38 8.6e-13 Inflammatory bowel disease; LUSC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg20203395 chr5:56204925 C5orf35 -0.81 -10.73 -0.51 2.93e-23 Initial pursuit acceleration; LUSC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg20243544 chr17:37824526 PNMT 0.52 7.41 0.38 1.06e-12 Asthma; LUSC cis rs9535307 0.769 rs9535306 chr13:50290817 A/G cg04663916 chr13:50265991 EBPL 0.49 6.31 0.33 8.8e-10 Obesity-related traits; LUSC cis rs7909074 0.899 rs2026428 chr10:45389452 T/C cg04218760 chr10:45406644 TMEM72 -0.3 -7.41 -0.38 1.03e-12 Mean corpuscular volume; LUSC cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg12011299 chr4:100065546 ADH4 -0.69 -10.82 -0.51 1.35e-23 Alcohol dependence; LUSC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg11812906 chr14:75593930 NEK9 0.63 10.04 0.48 6.8e-21 Height; LUSC cis rs2120019 0.935 rs34835684 chr15:75331805 T/G cg11632617 chr15:75315747 PPCDC -0.5 -6.45 -0.33 4.03e-10 Blood trace element (Zn levels); LUSC cis rs7677751 0.806 rs6836215 chr4:55102741 T/C cg17187183 chr4:55093834 PDGFRA 0.4 6.11 0.32 2.83e-9 Corneal astigmatism; LUSC cis rs77106637 0.932 rs2886599 chr11:72721271 C/A cg04827223 chr11:72435913 ARAP1 -0.67 -8.4 -0.42 1.28e-15 Type 2 diabetes; LUSC cis rs2295359 1.000 rs10889661 chr1:67625309 T/A cg12940439 chr1:67600707 NA 0.36 6.08 0.32 3.3e-9 Psoriasis; LUSC trans rs7829975 0.774 rs35431455 chr8:8673736 T/C cg21775007 chr8:11205619 TDH 0.46 6.56 0.34 2.06e-10 Mood instability; LUSC trans rs2262909 0.962 rs425781 chr19:22229306 A/G cg17074339 chr11:11642133 GALNTL4 -0.46 -7.07 -0.36 9.1e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg04871131 chr7:94954202 PON1 -0.38 -6.06 -0.31 3.74e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs877282 0.583 rs12358255 chr10:828626 C/T cg13775593 chr10:823151 NA 0.3 5.99 0.31 5.52e-9 Uric acid levels; LUSC trans rs7824557 0.872 rs2572431 chr8:11105077 C/T cg15556689 chr8:8085844 FLJ10661 -0.61 -9.56 -0.46 2.64e-19 Retinal vascular caliber; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03010907 chr6:131384623 EPB41L2 -0.49 -6.31 -0.33 9.11e-10 Bipolar disorder and schizophrenia; LUSC cis rs9325144 0.534 rs4882283 chr12:38710249 C/T cg13010199 chr12:38710504 ALG10B 0.5 7.81 0.39 7.56e-14 Morning vs. evening chronotype; LUSC cis rs459571 0.959 rs465535 chr9:136910905 C/T cg01294253 chr9:136912663 BRD3 0.36 6.35 0.33 6.86e-10 Platelet distribution width; LUSC cis rs983392 0.709 rs2015475 chr11:59998963 A/C cg24026212 chr11:59952134 MS4A6A -0.35 -6.1 -0.32 2.9e-9 Alzheimer's disease (late onset); LUSC cis rs6484504 0.625 rs796341 chr11:31414151 G/A cg06552810 chr11:31128660 NA 0.35 6.01 0.31 4.86e-9 Red blood cell count; LUSC trans rs4332037 0.901 rs7791299 chr7:1935598 T/C cg11693508 chr17:37793320 STARD3 0.59 7.66 0.39 2.04e-13 Bipolar disorder; LUSC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg06112835 chr11:68658793 MRPL21 0.52 7.78 0.39 8.9e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9815354 0.857 rs6798152 chr3:42023558 A/T cg03022575 chr3:42003672 ULK4 0.57 6.0 0.31 5.24e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs3764021 0.870 rs2401393 chr12:9879084 C/T cg20894963 chr12:9885564 CLECL1 0.34 7.0 0.36 1.44e-11 Type 1 diabetes; LUSC cis rs78545713 0.649 rs79308455 chr6:26224377 A/G cg23601095 chr6:26197514 HIST1H3D 0.66 5.79 0.3 1.64e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08109568 chr15:31115862 NA 0.67 9.83 0.47 3.49e-20 Huntington's disease progression; LUSC cis rs11249608 0.548 rs17078991 chr5:178459426 A/C cg21905437 chr5:178450457 ZNF879 0.43 5.71 0.3 2.54e-8 Pubertal anthropometrics; LUSC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg06238570 chr21:40685208 BRWD1 0.48 7.28 0.37 2.45e-12 Cognitive function; LUSC cis rs7605827 0.866 rs6717492 chr2:15538171 A/G cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg03526776 chr6:41159608 TREML2 0.34 6.53 0.34 2.51e-10 Alzheimer's disease (late onset); LUSC cis rs6693567 0.516 rs519126 chr1:150288859 T/G cg15654264 chr1:150340011 RPRD2 -0.44 -7.31 -0.37 1.98e-12 Migraine; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07805730 chr1:85156430 SSX2IP 0.45 6.09 0.32 3.16e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.56 0.34 2.09e-10 Menopause (age at onset); LUSC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg26597838 chr10:835615 NA 0.81 11.31 0.53 2.58e-25 Eosinophil percentage of granulocytes; LUSC trans rs6502050 0.805 rs9898507 chr17:80119628 C/T cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs240768 1.000 rs171257 chr6:101048197 T/A cg12253828 chr6:101329408 ASCC3 0.83 5.71 0.3 2.5e-8 Economic and political preferences (immigration/crime); LUSC cis rs7264396 0.635 rs6060709 chr20:34536022 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.0 -0.44 1.7e-17 Total cholesterol levels; LUSC cis rs1018836 0.923 rs12545279 chr8:91636373 C/G cg16814680 chr8:91681699 NA -0.75 -12.17 -0.55 1.84e-28 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9326248 0.520 rs7127881 chr11:116880798 G/A cg26566898 chr11:117069891 TAGLN 0.33 6.39 0.33 5.73e-10 Blood protein levels; LUSC cis rs11608355 0.545 rs36094325 chr12:109911542 A/T cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs6591182 0.504 rs7116712 chr11:65372518 A/G cg05805236 chr11:65401703 PCNXL3 -0.53 -8.93 -0.44 2.85e-17 Non-alcoholic fatty liver disease histology (lobular); LUSC cis rs950169 0.960 rs35159785 chr15:84804014 G/A cg12863693 chr15:85201151 NMB 0.36 7.01 0.36 1.34e-11 Schizophrenia; LUSC cis rs7809950 0.593 rs62482503 chr7:106987988 A/G cg23024343 chr7:107201750 COG5 -0.66 -9.92 -0.48 1.76e-20 Coronary artery disease; LUSC cis rs7712401 0.601 rs30035 chr5:122278545 A/G cg19077854 chr5:122220652 SNX24 0.41 9.16 0.45 5.23e-18 Mean platelet volume; LUSC trans rs35110281 0.715 rs8129601 chr21:45119104 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 9.15 0.45 5.56e-18 Mean corpuscular volume; LUSC cis rs5769707 0.967 rs8141807 chr22:50043738 C/G cg10356904 chr22:49881777 NA -0.32 -7.2 -0.37 4.03e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9905704 0.560 rs2632507 chr17:56530597 C/A cg19466818 chr17:56409534 MIR142 -0.36 -6.74 -0.35 7.06e-11 Testicular germ cell tumor; LUSC cis rs4988958 0.584 rs12712149 chr2:103045193 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.92e-12 Asthma (childhood onset); LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.71e-18 Breast cancer; LUSC cis rs2742234 0.504 rs7093409 chr10:43740067 A/G cg02780029 chr10:43622663 RET 0.32 5.85 0.3 1.19e-8 Hirschsprung disease; LUSC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.61e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9325144 0.647 rs12229104 chr12:39110811 T/A cg13010199 chr12:38710504 ALG10B -0.51 -7.88 -0.4 4.75e-14 Morning vs. evening chronotype; LUSC cis rs6977660 0.660 rs12531296 chr7:19816450 A/C cg05791153 chr7:19748676 TWISTNB 0.68 7.22 0.37 3.49e-12 Thyroid stimulating hormone; LUSC cis rs17253792 0.822 rs76267907 chr14:56066969 C/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg18681998 chr4:17616180 MED28 0.81 14.55 0.62 1.76e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9303280 0.806 rs8069176 chr17:38057197 G/A cg10909506 chr17:38081995 ORMDL3 0.34 6.07 0.32 3.53e-9 Self-reported allergy; LUSC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg05340658 chr4:99064831 C4orf37 0.62 9.77 0.47 5.28e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs847577 0.609 rs17435847 chr7:97792820 G/A cg21770322 chr7:97807741 LMTK2 0.56 10.24 0.49 1.34e-21 Breast cancer; LUSC cis rs9393777 0.920 rs13195040 chr6:27413924 C/T cg26958806 chr6:27640298 NA -0.74 -6.1 -0.32 2.94e-9 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg00750074 chr16:89608354 SPG7 -0.54 -9.79 -0.47 4.57e-20 Multiple myeloma (IgH translocation); LUSC cis rs2479724 0.776 rs2250428 chr6:41832772 T/A cg17623882 chr6:41773611 USP49 -0.59 -10.1 -0.48 4.22e-21 Menarche (age at onset); LUSC cis rs66887589 0.616 rs11731675 chr4:120212514 T/C cg09307838 chr4:120376055 NA 0.51 7.71 0.39 1.48e-13 Diastolic blood pressure; LUSC cis rs2219968 0.676 rs11781543 chr8:78836409 C/T cg00738934 chr8:78996279 NA -0.35 -6.0 -0.31 5.12e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs1997103 1.000 rs2177802 chr7:55410789 G/A cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg11584989 chr19:19387371 SF4 0.6 7.08 0.36 8.81e-12 Bipolar disorder; LUSC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg03732007 chr1:2071316 PRKCZ -0.53 -9.49 -0.46 4.59e-19 Height; LUSC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg15105969 chr2:36825350 FEZ2 -0.51 -7.47 -0.38 7.07e-13 Height; LUSC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.19 0.37 4.33e-12 Mean platelet volume; LUSC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg06544989 chr22:39130855 UNC84B 0.37 6.41 0.33 5.04e-10 Menopause (age at onset); LUSC trans rs12200782 1.000 rs12208390 chr6:26437106 C/T cg11837749 chr1:55047332 ACOT11 0.58 6.23 0.32 1.41e-9 Small cell lung carcinoma; LUSC cis rs7818345 1.000 rs13278459 chr8:19297583 A/G cg11303988 chr8:19266685 CSGALNACT1 0.37 7.12 0.36 6.78e-12 Language performance in older adults (adjusted for episodic memory); LUSC trans rs2018683 0.707 rs4719961 chr7:28969513 C/T cg19402173 chr7:128379420 CALU -0.46 -7.11 -0.36 6.93e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs116095464 0.614 rs10059220 chr5:242813 C/T cg22857025 chr5:266934 NA -1.16 -14.35 -0.62 1.06e-36 Breast cancer; LUSC cis rs11711311 0.668 rs11718061 chr3:113341826 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.43 5.83 0.3 1.27e-8 IgG glycosylation; LUSC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg22307029 chr19:49891270 CCDC155 0.63 8.09 0.4 1.13e-14 Multiple sclerosis; LUSC trans rs208520 1.000 rs208537 chr6:66963544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.34 -0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs11122272 0.735 rs2739507 chr1:231527329 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.77 -0.47 5.47e-20 Hemoglobin concentration; LUSC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.41 0.46 8.32e-19 Monocyte percentage of white cells; LUSC cis rs9527 0.615 rs4917991 chr10:104783833 T/C cg05855489 chr10:104503620 C10orf26 0.53 8.11 0.41 9.87e-15 Arsenic metabolism; LUSC cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg17420585 chr12:42539391 GXYLT1 -0.4 -7.97 -0.4 2.61e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9443645 0.527 rs1413969 chr6:79790982 A/G cg05283184 chr6:79620031 NA -0.47 -8.97 -0.44 2.13e-17 Intelligence (multi-trait analysis); LUSC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg24296786 chr1:45957014 TESK2 0.47 6.86 0.35 3.33e-11 High light scatter reticulocyte count; LUSC cis rs7771547 0.589 rs6941918 chr6:36514721 T/G cg07856975 chr6:36356162 ETV7 0.41 6.01 0.31 4.76e-9 Platelet distribution width; LUSC trans rs11098499 0.691 rs12502524 chr4:120271414 G/A cg25214090 chr10:38739885 LOC399744 0.39 5.96 0.31 6.43e-9 Corneal astigmatism; LUSC trans rs2262909 0.849 rs2666447 chr19:22132868 T/A cg05197062 chr11:11642011 GALNTL4 -0.5 -6.96 -0.36 1.78e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4820294 1.000 rs713835 chr22:38064650 C/T cg21798802 chr22:38057573 PDXP 0.48 10.64 0.5 6.02e-23 Fat distribution (HIV); LUSC cis rs9790314 0.740 rs4856767 chr3:161004379 C/T cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 3.88e-20 Morning vs. evening chronotype; LUSC cis rs2455601 0.638 rs2568092 chr11:8987438 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.4 6.29 0.33 9.73e-10 Schizophrenia; LUSC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg18681998 chr4:17616180 MED28 0.83 15.21 0.64 4.52e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9527 0.590 rs7917650 chr10:104937100 G/C cg04362960 chr10:104952993 NT5C2 0.61 9.4 0.46 8.7e-19 Arsenic metabolism; LUSC trans rs5756813 0.727 rs4239889 chr22:38140352 T/G cg19894588 chr14:64061835 NA -0.56 -7.34 -0.37 1.68e-12 Optic cup area;Vertical cup-disc ratio; LUSC cis rs10992471 0.528 rs10117627 chr9:95203953 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.25 -0.32 1.23e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6964587 0.626 rs10243083 chr7:91552530 G/A cg17063962 chr7:91808500 NA -0.56 -9.23 -0.45 3.27e-18 Breast cancer; LUSC trans rs11098499 0.663 rs9996501 chr4:120238918 C/A cg25214090 chr10:38739885 LOC399744 0.42 6.3 0.33 9.58e-10 Corneal astigmatism; LUSC cis rs9653442 1.000 rs1160542 chr2:100832155 A/G cg22139774 chr2:100720529 AFF3 0.44 7.77 0.39 9.6e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs911119 0.954 rs35966482 chr20:23620716 G/T cg16589663 chr20:23618590 CST3 0.59 6.95 0.36 1.9e-11 Chronic kidney disease; LUSC cis rs2758596 1.000 rs2758617 chr1:156160693 A/G cg25208724 chr1:156163844 SLC25A44 0.78 6.37 0.33 6.32e-10 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs2406342 0.528 rs75536638 chr18:74499060 G/T cg16472389 chr18:74514291 NA 0.63 9.64 0.47 1.49e-19 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); LUSC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11644478 chr21:40555479 PSMG1 0.96 19.16 0.72 1.04e-55 Cognitive function; LUSC cis rs2235544 0.565 rs635509 chr1:54469227 A/G cg25741118 chr1:54482237 LDLRAD1 0.28 5.98 0.31 5.61e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC trans rs9472138 0.756 rs2396084 chr6:43804825 A/G cg19073447 chr10:134024191 STK32C 0.38 6.0 0.31 5.21e-9 Type 2 diabetes;Thyroid hormone levels; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24001477 chr11:31531492 ELP4;IMMP1L 0.4 6.44 0.33 4.2e-10 Asthma; LUSC trans rs75804782 0.641 rs55740938 chr2:239332647 G/A cg01134436 chr17:81009848 B3GNTL1 0.67 6.04 0.31 4.2e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs2274273 0.840 rs72715769 chr14:55762429 C/G cg04306507 chr14:55594613 LGALS3 0.54 12.08 0.55 3.86e-28 Protein biomarker; LUSC cis rs3820928 0.839 rs13413292 chr2:227893747 G/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.57 -0.38 3.59e-13 Pulmonary function; LUSC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.12 0.52 1.21e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg23711669 chr6:146136114 FBXO30 -0.74 -13.05 -0.58 1.02e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.39e-13 Bipolar disorder; LUSC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.6e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs847577 0.540 rs3847055 chr7:97680645 A/G cg21770322 chr7:97807741 LMTK2 -0.39 -5.8 -0.3 1.53e-8 Breast cancer; LUSC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg22920501 chr2:26401640 FAM59B 0.76 10.9 0.51 7.4e-24 Gut microbiome composition (summer); LUSC cis rs10865397 0.506 rs6546810 chr2:73389716 A/G cg24220031 chr2:73402428 NA -0.26 -6.17 -0.32 1.96e-9 Intelligence (multi-trait analysis); LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.91 -13.58 -0.6 9.61e-34 Alzheimer's disease; LUSC cis rs10792830 1.000 rs10792830 chr11:85838808 G/A cg07180834 chr11:85838833 NA -0.3 -5.84 -0.3 1.25e-8 Psychosis and Alzheimer's disease; LUSC cis rs4664308 0.692 rs10497213 chr2:160963603 G/A cg03641300 chr2:160917029 PLA2R1 -0.62 -10.2 -0.49 1.94e-21 Idiopathic membranous nephropathy; LUSC cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg03264133 chr6:25882463 NA -0.5 -9.11 -0.45 7.57e-18 Blood metabolite levels; LUSC cis rs4363385 0.782 rs10788857 chr1:153024941 T/G cg00922841 chr1:152955080 SPRR1A -0.43 -7.41 -0.38 1.07e-12 Inflammatory skin disease; LUSC cis rs367615 0.660 rs4632850 chr5:108832883 C/G cg17395555 chr5:108820864 NA 0.64 11.5 0.53 5.31e-26 Colorectal cancer (SNP x SNP interaction); LUSC cis rs763121 0.962 rs138711 chr22:39139913 C/T cg06022373 chr22:39101656 GTPBP1 0.66 9.43 0.46 7.12e-19 Menopause (age at onset); LUSC cis rs9905704 0.918 rs302862 chr17:56697444 G/T cg12560992 chr17:57184187 TRIM37 0.55 7.74 0.39 1.19e-13 Testicular germ cell tumor; LUSC trans rs6598955 0.671 rs12068212 chr1:26612935 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.86 -0.44 4.74e-17 Obesity-related traits; LUSC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg12963246 chr6:28129442 ZNF389 0.38 5.66 0.3 3.28e-8 Cardiac Troponin-T levels; LUSC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 10.02 0.48 7.97e-21 Personality dimensions; LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.05 -0.31 3.89e-9 Platelet count; LUSC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg05025164 chr4:1340916 KIAA1530 0.54 8.45 0.42 9.43e-16 Longevity; LUSC cis rs9309711 0.922 rs11679058 chr2:3483813 C/G cg10845886 chr2:3471009 TTC15 -0.61 -7.75 -0.39 1.09e-13 Neurofibrillary tangles; LUSC cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.11 0.41 9.98e-15 Axial length; LUSC cis rs6087990 0.863 rs1569686 chr20:31367079 G/T cg13636640 chr20:31349939 DNMT3B 0.99 21.29 0.76 3.66e-64 Ulcerative colitis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05743054 chr3:158288903 MLF1 0.53 7.45 0.38 7.99e-13 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7781370 0.961 rs4383904 chr7:96121636 T/C cg00604640 chr7:96133485 NA -0.33 -5.82 -0.3 1.36e-8 Bone mineral density (hip); LUSC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg14664628 chr15:75095509 CSK -0.55 -8.59 -0.43 3.37e-16 Breast cancer; LUSC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg15445000 chr17:37608096 MED1 -0.39 -6.71 -0.34 8.49e-11 Glomerular filtration rate (creatinine); LUSC cis rs9814567 1.000 rs4334685 chr3:134304335 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.56 -0.34 2.04e-10 Neuroticism; LUSC trans rs67340775 0.541 rs200974 chr6:27855845 A/G cg05267876 chr1:229644265 NUP133 -0.56 -6.08 -0.32 3.25e-9 Lung cancer in ever smokers; LUSC trans rs72674100 1.000 rs72882340 chr4:97993584 A/C cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs748404 0.631 rs560191 chr15:43767774 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg18240062 chr17:79603768 NPLOC4 -0.68 -12.43 -0.56 2.05e-29 Eye color traits; LUSC cis rs6484504 0.576 rs208072 chr11:31141288 A/G cg06552810 chr11:31128660 NA 0.4 7.17 0.37 4.83e-12 Red blood cell count; LUSC cis rs9393692 0.645 rs766407 chr6:26319534 T/C cg00631329 chr6:26305371 NA -0.54 -10.61 -0.5 7.47e-23 Educational attainment; LUSC trans rs11696501 0.789 rs1487319 chr20:44295943 A/G cg03272292 chr12:48577362 C12orf68 0.49 5.95 0.31 6.79e-9 Brain structure; LUSC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 6.13 0.32 2.52e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg13531842 chr10:38383804 ZNF37A -0.46 -7.23 -0.37 3.4e-12 Extrinsic epigenetic age acceleration; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg13679077 chr7:22862647 TOMM7 0.38 6.01 0.31 4.92e-9 Schizophrenia; LUSC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg03732007 chr1:2071316 PRKCZ -0.55 -9.89 -0.48 2.07e-20 Height; LUSC cis rs11122272 0.735 rs910824 chr1:231498773 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.93 -0.48 1.59e-20 Hemoglobin concentration; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25814383 chr19:19336240 NCAN 0.74 6.85 0.35 3.65e-11 Cognitive performance; LUSC trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg08975724 chr8:8085496 FLJ10661 -0.49 -7.03 -0.36 1.17e-11 Monocyte count; LUSC trans rs61931739 0.534 rs10844728 chr12:34020109 G/C cg13010199 chr12:38710504 ALG10B 0.56 8.38 0.42 1.49e-15 Morning vs. evening chronotype; LUSC cis rs1729407 0.786 rs5100 chr11:116692694 G/A cg08985259 chr11:116699649 APOC3 -0.25 -5.78 -0.3 1.76e-8 Apolipoprotein A-IV levels; LUSC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg24250549 chr1:154909240 PMVK 0.65 10.87 0.51 9.05e-24 Prostate cancer; LUSC cis rs8062405 0.755 rs56209193 chr16:28585636 C/T cg07382826 chr16:28625726 SULT1A1 0.27 5.78 0.3 1.68e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs3126085 0.935 rs12726613 chr1:152185500 C/G cg26876637 chr1:152193138 HRNR -0.42 -5.92 -0.31 7.86e-9 Atopic dermatitis; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.71 10.92 0.51 6.12e-24 Lymphocyte counts; LUSC cis rs67072384 1.000 rs7124056 chr11:72444747 C/T cg04827223 chr11:72435913 ARAP1 0.73 7.12 0.36 6.54e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.64 0.63 8.06e-38 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs3771570 1.000 rs7557535 chr2:242206555 T/C cg21155796 chr2:242212141 HDLBP 0.68 7.52 0.38 5.12e-13 Prostate cancer; LUSC cis rs472402 0.623 rs8192131 chr5:6636465 C/T cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.51 -7.69 -0.39 1.66e-13 Response to amphetamines; LUSC cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg06550200 chr5:1325588 CLPTM1L -0.64 -11.0 -0.52 3.06e-24 Lung cancer; LUSC cis rs35123781 0.955 rs34530707 chr5:139059016 G/A cg10513866 chr5:139070639 NA 0.46 8.96 0.44 2.35e-17 Schizophrenia; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg21733973 chr7:65235735 NA 0.41 5.74 0.3 2.09e-8 Calcium levels; LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.08 16.73 0.68 4.74e-46 Gut microbiome composition (summer); LUSC trans rs3942852 0.545 rs7395231 chr11:48091689 T/C cg03929089 chr4:120376271 NA -0.58 -7.46 -0.38 7.43e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs2692947 0.702 rs6717101 chr2:96505552 C/T cg22654517 chr2:96458247 NA 0.38 7.5 0.38 5.99e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg17366294 chr4:99064904 C4orf37 0.59 10.46 0.5 2.54e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg14541582 chr5:601475 NA -0.37 -5.65 -0.3 3.43e-8 Lung disease severity in cystic fibrosis; LUSC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg04518342 chr5:131593106 PDLIM4 0.45 8.29 0.41 2.72e-15 Breast cancer; LUSC cis rs7000551 0.689 rs4872000 chr8:22337323 G/T cg12081754 chr8:22256438 SLC39A14 0.44 6.78 0.35 5.58e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs79387448 0.745 rs75644281 chr2:103151316 A/T cg09003973 chr2:102972529 NA 0.86 8.44 0.42 9.66e-16 Gut microbiota (bacterial taxa); LUSC cis rs17125944 0.505 rs77690283 chr14:53233320 C/G cg13660082 chr14:53194042 PSMC6 -0.78 -6.81 -0.35 4.55e-11 Alzheimer's disease (late onset); LUSC cis rs1008375 0.863 rs10003291 chr4:17600728 A/C cg16339924 chr4:17578868 LAP3 0.63 9.45 0.46 6.16e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6121246 0.567 rs2811 chr20:30194248 A/G cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg14895029 chr7:2775587 GNA12 -0.44 -6.89 -0.35 2.81e-11 Height; LUSC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC cis rs7202877 0.610 rs3851735 chr16:75372092 A/G cg04384234 chr16:75411784 CFDP1 -0.59 -7.85 -0.39 5.82e-14 Type 2 diabetes;Type 1 diabetes; LUSC trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg21153622 chr11:89784906 NA -0.39 -6.0 -0.31 5.01e-9 HDL cholesterol; LUSC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11644478 chr21:40555479 PSMG1 0.95 18.49 0.71 4.54e-53 Cognitive function; LUSC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg11062466 chr8:58055876 NA 0.51 6.5 0.33 2.98e-10 Developmental language disorder (linguistic errors); LUSC cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg02527881 chr3:46936655 PTH1R 0.38 6.53 0.34 2.42e-10 Colorectal cancer; LUSC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg22823121 chr1:150693482 HORMAD1 0.57 8.78 0.43 8.67e-17 Melanoma; LUSC cis rs2242116 0.932 rs4683301 chr3:46931478 A/T cg23352942 chr3:46931381 PTH1R 0.39 7.67 0.39 1.93e-13 Birth weight; LUSC cis rs9653442 0.564 rs10175599 chr2:100787635 C/T cg22139774 chr2:100720529 AFF3 -0.41 -7.04 -0.36 1.09e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg08200582 chr11:442649 ANO9 -0.57 -6.4 -0.33 5.31e-10 Body mass index; LUSC cis rs1215050 0.755 rs6851840 chr4:98776366 A/G cg05340658 chr4:99064831 C4orf37 0.45 7.08 0.36 8.69e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg01879757 chr17:41196368 BRCA1 -0.5 -7.94 -0.4 3.06e-14 Menopause (age at onset); LUSC cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg23277830 chr1:3704460 LRRC47 0.35 6.68 0.34 9.77e-11 Red cell distribution width; LUSC trans rs6952808 0.595 rs3800917 chr7:2167939 A/G cg04565464 chr8:145669602 NFKBIL2 -0.37 -5.98 -0.31 5.67e-9 Bipolar disorder and schizophrenia; LUSC cis rs12210905 0.925 rs115507154 chr6:26970811 C/A cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.51e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.83e-30 Motion sickness; LUSC cis rs9906944 0.707 rs4794019 chr17:47107290 G/T cg14634687 chr17:47094252 IGF2BP1 0.32 6.96 0.36 1.79e-11 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs826838 0.967 rs826858 chr12:39116731 A/G cg26384229 chr12:38710491 ALG10B -0.83 -15.53 -0.65 2.62e-41 Heart rate; LUSC cis rs12579753 0.871 rs10862363 chr12:82201254 T/A cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC trans rs2727020 0.595 rs10839286 chr11:49497063 C/A cg15704280 chr7:45808275 SEPT13 -1.1 -22.13 -0.77 1.93e-67 Coronary artery disease; LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.92e-21 Monocyte count; LUSC cis rs6142102 0.961 rs4911392 chr20:32570518 G/C cg08999081 chr20:33150536 PIGU 0.34 5.9 0.31 9.15e-9 Skin pigmentation; LUSC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.5 0.42 6.51e-16 Hip circumference adjusted for BMI; LUSC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.5 7.34 0.37 1.6e-12 Personality dimensions; LUSC cis rs17253792 0.822 rs17683614 chr14:56041058 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs2204008 0.654 rs1290325 chr12:38152910 C/T cg26384229 chr12:38710491 ALG10B -0.69 -10.82 -0.51 1.38e-23 Bladder cancer; LUSC cis rs447735 0.587 rs11640702 chr16:89729169 A/G cg03605463 chr16:89740564 NA -0.55 -8.7 -0.43 1.55e-16 Hemoglobin concentration; LUSC trans rs208520 0.690 rs1776365 chr6:66834474 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -17.14 -0.68 1.09e-47 Exhaled nitric oxide output; LUSC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg04315214 chr1:2043799 PRKCZ -0.37 -7.27 -0.37 2.61e-12 Height; LUSC cis rs9311676 0.656 rs11721168 chr3:58408679 G/A cg13750441 chr3:58318267 PXK 0.35 6.77 0.35 5.86e-11 Systemic lupus erythematosus; LUSC cis rs6750047 0.932 rs2116232 chr2:38268718 C/A cg07380506 chr2:38303506 CYP1B1 0.47 6.5 0.34 2.85e-10 Cutaneous malignant melanoma;Melanoma; LUSC cis rs2439831 0.867 rs2614811 chr15:43913487 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.83 8.6 0.43 3.14e-16 Lung cancer in ever smokers; LUSC cis rs554111 0.634 rs10799673 chr1:21274671 T/G cg01072550 chr1:21505969 NA 0.39 6.0 0.31 5.01e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs877282 0.891 rs11595385 chr10:800539 A/G cg17470449 chr10:769945 NA 0.49 6.44 0.33 4.26e-10 Uric acid levels; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.29 0.45 2.01e-18 Prudent dietary pattern; LUSC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg16524733 chr11:117070046 TAGLN 0.44 7.73 0.39 1.29e-13 Blood protein levels; LUSC cis rs9359856 0.564 rs36040566 chr6:90372574 A/C cg13799429 chr6:90582589 CASP8AP2 -0.89 -8.73 -0.43 1.25e-16 Bipolar disorder; LUSC cis rs68170813 0.599 rs77878465 chr7:106890996 G/A cg02696742 chr7:106810147 HBP1 -0.62 -9.43 -0.46 7.17e-19 Coronary artery disease; LUSC trans rs2739330 0.760 rs5751761 chr22:24243736 A/G cg06437703 chr8:37914619 EIF4EBP1 0.51 8.66 0.43 2.06e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12472274 0.646 rs11688732 chr2:239096622 G/T cg17459225 chr2:239074497 NA 0.58 7.94 0.4 3.18e-14 Phospholipid levels (plasma); LUSC cis rs7615316 0.934 rs6791816 chr3:142233990 T/C cg16271453 chr3:142027066 XRN1 -0.4 -6.88 -0.35 3.04e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg07828340 chr4:882639 GAK 1.0 11.54 0.53 3.69e-26 Intelligence (multi-trait analysis); LUSC cis rs73206853 0.841 rs73191816 chr12:110918564 G/A cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9549367 0.789 rs7338235 chr13:113888687 T/C cg18105134 chr13:113819100 PROZ -0.67 -9.47 -0.46 5.26e-19 Platelet distribution width; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18099408 chr3:52552593 STAB1 -0.41 -7.25 -0.37 2.99e-12 Electroencephalogram traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22346429 chr12:132504721 EP400 0.46 6.27 0.32 1.13e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg13206674 chr6:150067644 NUP43 0.62 10.12 0.48 3.53e-21 Lung cancer; LUSC cis rs262150 0.566 rs262159 chr7:158772172 C/T cg12590608 chr7:158785262 NA -0.35 -6.05 -0.31 3.84e-9 Facial morphology (factor 20); LUSC cis rs6087990 0.735 rs1040554 chr20:31380073 C/T cg13636640 chr20:31349939 DNMT3B 0.91 18.72 0.72 5.65e-54 Ulcerative colitis; LUSC cis rs9653442 1.000 rs11676922 chr2:100806940 T/A cg22139774 chr2:100720529 AFF3 -0.44 -8.01 -0.4 1.95e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg15790184 chr11:494944 RNH1 0.53 6.01 0.31 4.84e-9 Body mass index; LUSC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg18230493 chr5:56204884 C5orf35 -1.01 -15.27 -0.64 2.58e-40 Initial pursuit acceleration; LUSC cis rs17253792 0.822 rs78820104 chr14:56068854 C/T cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg04414720 chr1:150670196 GOLPH3L -0.43 -6.66 -0.34 1.1e-10 Tonsillectomy; LUSC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg16989086 chr20:62203971 PRIC285 0.46 6.41 0.33 5.09e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg13206674 chr6:150067644 NUP43 0.62 9.96 0.48 1.24e-20 Lung cancer; LUSC cis rs7177699 0.557 rs7176187 chr15:79121373 A/G cg15571903 chr15:79123663 NA 0.33 6.02 0.31 4.49e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11018904 0.906 rs10501713 chr11:89953013 G/A cg26834418 chr11:89957033 CHORDC1 -0.51 -6.28 -0.32 1.06e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6674176 0.932 rs7412307 chr1:44433864 C/G cg12908607 chr1:44402522 ARTN 0.48 6.92 0.35 2.36e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg07636037 chr3:49044803 WDR6 -0.66 -8.39 -0.42 1.36e-15 Menarche (age at onset); LUSC cis rs6570726 1.000 rs6570699 chr6:145920732 G/A cg23711669 chr6:146136114 FBXO30 0.74 12.45 0.56 1.76e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs7582180 0.700 rs4640404 chr2:100980523 C/T cg12002119 chr2:101014098 CHST10 -0.38 -6.31 -0.33 9.01e-10 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11644478 chr21:40555479 PSMG1 -0.78 -13.77 -0.6 1.8e-34 Cognitive function; LUSC cis rs11158026 0.757 rs9285583 chr14:55431435 T/C cg04306507 chr14:55594613 LGALS3 0.34 6.48 0.33 3.27e-10 Parkinson's disease; LUSC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg23172400 chr8:95962367 TP53INP1 -0.39 -7.96 -0.4 2.62e-14 Type 2 diabetes; LUSC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs12464559 0.522 rs7583148 chr2:152620986 C/T cg01189475 chr2:152685088 ARL5A 0.64 6.99 0.36 1.49e-11 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs7098414 0.511 rs7907575 chr10:82152675 T/G cg01528321 chr10:82214614 TSPAN14 0.61 9.07 0.44 1.06e-17 Post bronchodilator FEV1; LUSC cis rs7512552 0.839 rs1694362 chr1:150366963 T/A cg15654264 chr1:150340011 RPRD2 0.66 10.96 0.51 4.44e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9325144 0.554 rs7960616 chr12:39096664 T/A cg13010199 chr12:38710504 ALG10B -0.52 -7.93 -0.4 3.26e-14 Morning vs. evening chronotype; LUSC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg13902645 chr11:5959945 NA -0.53 -8.33 -0.41 2.08e-15 DNA methylation (variation); LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg22535103 chr8:58192502 C8orf71 -0.72 -7.55 -0.38 4.13e-13 Developmental language disorder (linguistic errors); LUSC cis rs4969178 0.930 rs11077363 chr17:76397309 C/T cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg21028142 chr17:79581711 NPLOC4 -0.32 -7.49 -0.38 6.23e-13 Eye color traits; LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg22963979 chr7:1858916 MAD1L1 -0.47 -6.87 -0.35 3.18e-11 Bipolar disorder and schizophrenia; LUSC cis rs8014204 0.762 rs10148293 chr14:75296831 C/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -8.11 -0.41 9.81e-15 Caffeine consumption; LUSC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -9.91 -0.48 1.88e-20 Personality dimensions; LUSC cis rs2479724 0.613 rs9367113 chr6:41809801 T/G cg17623882 chr6:41773611 USP49 -0.53 -7.35 -0.37 1.51e-12 Menarche (age at onset); LUSC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg05861140 chr6:150128134 PCMT1 -0.39 -5.89 -0.31 9.35e-9 Lung cancer; LUSC cis rs35486314 1 rs35486314 chr1:150901861 A/AT cg13175981 chr1:150552382 MCL1 0.46 6.43 0.33 4.43e-10 Monocyte chemoattractant protein-1 levels; LUSC cis rs13401104 0.740 rs12465430 chr2:237113578 C/T cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.35e-8 Educational attainment; LUSC cis rs782590 0.774 rs782629 chr2:55900283 C/T cg03859395 chr2:55845619 SMEK2 -0.84 -15.21 -0.64 4.68e-40 Metabolic syndrome; LUSC cis rs11690935 0.550 rs7584187 chr2:172866105 A/G cg13550731 chr2:172543902 DYNC1I2 -0.53 -8.18 -0.41 6.15e-15 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23260799 chr11:451101 PTDSS2 0.41 6.37 0.33 6.13e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7178572 1.000 rs7178572 chr15:77747190 A/G cg22256960 chr15:77711686 NA -0.53 -8.99 -0.44 1.84e-17 Type 2 diabetes; LUSC cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg24558204 chr6:135376177 HBS1L -0.58 -8.9 -0.44 3.69e-17 Red blood cell count; LUSC cis rs17433780 0.808 rs1074541 chr1:89509499 A/G cg09516651 chr1:89888402 LOC400759 0.61 11.67 0.54 1.25e-26 Carotid intima media thickness; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14210236 chr1:145208980 NOTCH2NL -0.44 -6.37 -0.33 6.43e-10 Electrocardiographic conduction measures; LUSC cis rs12220238 1.000 rs10824084 chr10:75911415 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.27 0.37 2.65e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2486288 0.656 rs8037583 chr15:45546378 A/G cg09092052 chr15:45571596 NA 0.42 5.77 0.3 1.85e-8 Glomerular filtration rate; LUSC cis rs72781680 0.898 rs72786286 chr2:24074659 T/A cg08917208 chr2:24149416 ATAD2B 0.86 9.63 0.47 1.53e-19 Lymphocyte counts; LUSC cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg08477640 chr19:41863820 B9D2 0.53 7.68 0.39 1.75e-13 Colorectal cancer; LUSC trans rs3749237 0.964 rs34522271 chr3:49808517 A/G cg21659725 chr3:3221576 CRBN 0.62 8.77 0.43 9.55e-17 Resting heart rate; LUSC cis rs2274273 0.661 rs2147964 chr14:55564395 T/G cg04306507 chr14:55594613 LGALS3 0.5 10.87 0.51 9.15e-24 Protein biomarker; LUSC cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg22431228 chr1:16359049 CLCNKA -0.56 -12.39 -0.56 2.84e-29 Systolic blood pressure; LUSC cis rs3772130 1.000 rs17691170 chr3:121357626 G/C cg01951420 chr3:121553821 IQCB1;EAF2 0.66 9.57 0.46 2.47e-19 Cognitive performance; LUSC cis rs394563 0.591 rs237019 chr6:149727064 G/A cg07828024 chr6:149772892 ZC3H12D -0.34 -7.51 -0.38 5.51e-13 Dupuytren's disease; LUSC cis rs9902453 0.904 rs7212292 chr17:28409264 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.64 -0.5 5.77e-23 Coffee consumption (cups per day); LUSC cis rs4595586 0.545 rs12831116 chr12:39401456 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.53 0.38 4.83e-13 Morning vs. evening chronotype; LUSC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg07741184 chr6:167504864 NA -0.35 -6.39 -0.33 5.46e-10 Crohn's disease; LUSC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -8.63 -0.43 2.58e-16 Hemoglobin concentration; LUSC cis rs17270561 0.609 rs2275905 chr6:25768106 G/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.32 0.37 1.81e-12 Iron status biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08679808 chr17:79886116 LOC92659;MAFG -0.49 -6.5 -0.34 2.91e-10 Bipolar disorder and schizophrenia; LUSC cis rs7267979 1.000 rs2482943 chr20:25380593 G/A cg08601574 chr20:25228251 PYGB -0.44 -6.76 -0.35 6.17e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg18351406 chr4:77819688 ANKRD56 0.55 8.19 0.41 5.55e-15 Emphysema distribution in smoking; LUSC cis rs2224391 0.628 rs9392666 chr6:5249888 C/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.49 -6.75 -0.35 6.5500000000000006e-11 Height; LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg21782813 chr7:2030301 MAD1L1 0.48 8.12 0.41 9.21e-15 Bipolar disorder and schizophrenia; LUSC cis rs61931739 0.635 rs10743836 chr12:33961680 C/T cg06521331 chr12:34319734 NA -0.41 -6.72 -0.35 7.9e-11 Morning vs. evening chronotype; LUSC cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg04450456 chr4:17643702 FAM184B -0.4 -6.43 -0.33 4.33e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.67 -0.3 3.01e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7666738 0.606 rs3846447 chr4:99099907 G/A cg05340658 chr4:99064831 C4orf37 0.58 9.44 0.46 6.74e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg14092988 chr3:52407081 DNAH1 0.31 5.96 0.31 6.37e-9 Bipolar disorder; LUSC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg23630131 chr7:65973040 NA 0.21 5.83 0.3 1.33e-8 Aortic root size; LUSC cis rs6696846 0.630 rs6692706 chr1:205158561 G/T cg03948781 chr1:205179583 DSTYK 0.32 6.21 0.32 1.61e-9 Red blood cell count; LUSC cis rs9394931 1.000 rs9394931 chr6:42873245 C/T cg27588902 chr6:42928151 GNMT 0.28 5.91 0.31 8.42e-9 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); LUSC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.73 0.35 7.44e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs1775715 0.737 rs2799012 chr10:32103077 C/T cg26784012 chr10:32216390 ARHGAP12 0.44 7.39 0.37 1.21e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg17143192 chr8:8559678 CLDN23 0.38 5.98 0.31 5.62e-9 Mood instability; LUSC cis rs6942756 0.955 rs68187585 chr7:129002211 T/C cg02491457 chr7:128862824 NA -0.53 -7.07 -0.36 8.91e-12 White matter hyperintensity burden; LUSC cis rs9790314 1.000 rs336567 chr3:161073046 A/G cg04691961 chr3:161091175 C3orf57 -0.35 -6.06 -0.31 3.63e-9 Morning vs. evening chronotype; LUSC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.46 0.46 5.81e-19 Personality dimensions; LUSC cis rs11871801 0.517 rs35635959 chr17:40772288 T/C cg16308533 chr17:40838983 CNTNAP1 0.39 5.8 0.3 1.55e-8 Crohn's disease; LUSC cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.07 0.48 5.08e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9303280 0.901 rs7359623 chr17:38049589 C/T cg10909506 chr17:38081995 ORMDL3 0.34 5.91 0.31 8.59e-9 Self-reported allergy; LUSC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg27494647 chr7:150038898 RARRES2 0.35 5.69 0.3 2.77e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg09877947 chr5:131593287 PDLIM4 -0.44 -6.62 -0.34 1.44e-10 Breast cancer; LUSC cis rs35146811 0.695 rs858509 chr7:99821470 A/G cg22906224 chr7:99728672 NA -0.5 -6.99 -0.36 1.49e-11 Coronary artery disease; LUSC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg06108461 chr20:60628389 TAF4 -1.01 -16.99 -0.68 4.2e-47 Body mass index; LUSC cis rs1595825 0.891 rs16867018 chr2:198521490 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.34e-10 Ulcerative colitis; LUSC cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs10256972 0.630 rs10282584 chr7:1081442 C/T cg18765753 chr7:1198926 ZFAND2A -0.33 -5.87 -0.31 1.06e-8 Longevity;Endometriosis; LUSC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg23422044 chr7:1970798 MAD1L1 -0.57 -6.36 -0.33 6.75e-10 Bipolar disorder; LUSC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg04414720 chr1:150670196 GOLPH3L -0.56 -9.09 -0.45 9.24e-18 Tonsillectomy; LUSC cis rs2274273 0.905 rs4652 chr14:55605036 A/C cg04306507 chr14:55594613 LGALS3 0.58 13.39 0.59 4.93e-33 Protein biomarker; LUSC cis rs782590 0.582 rs2627767 chr2:55926815 A/T cg03859395 chr2:55845619 SMEK2 0.74 12.1 0.55 3.49e-28 Metabolic syndrome; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg06600287 chr1:53387719 ECHDC2 -0.28 -5.72 -0.3 2.34e-8 Monocyte count; LUSC cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg20701182 chr2:24300061 SF3B14 0.88 11.42 0.53 1.05e-25 Lymphocyte counts; LUSC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg06008330 chr7:65541103 ASL -0.4 -6.37 -0.33 6.37e-10 Aortic root size; LUSC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg02423579 chr7:2872169 GNA12 -0.42 -6.32 -0.33 8.35e-10 Height; LUSC cis rs1568889 0.938 rs6484358 chr11:28260364 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 9.43 0.46 7.39e-19 Bipolar disorder; LUSC cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg07148914 chr20:33460835 GGT7 0.54 8.42 0.42 1.11e-15 Height; LUSC cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg23229984 chr5:148520753 ABLIM3 0.41 6.47 0.33 3.4e-10 Breast cancer; LUSC cis rs9341808 0.727 rs4706834 chr6:81012605 G/T cg08355045 chr6:80787529 NA 0.56 9.8 0.47 4.15e-20 Sitting height ratio; LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg08859206 chr1:53392774 SCP2 0.55 9.48 0.46 5.03e-19 Monocyte count; LUSC cis rs477692 0.905 rs570967 chr10:131421330 T/G cg05714579 chr10:131428358 MGMT 0.52 7.9 0.4 4e-14 Response to temozolomide; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg25767906 chr1:53392781 SCP2 -0.57 -11.35 -0.53 1.82e-25 Monocyte count; LUSC cis rs6688613 0.685 rs11579987 chr1:166889364 C/G cg07049167 chr1:166818506 POGK -0.42 -5.95 -0.31 6.72e-9 Refractive astigmatism; LUSC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg22307029 chr19:49891270 CCDC155 0.58 7.61 0.38 2.9e-13 Multiple sclerosis; LUSC cis rs1832871 0.672 rs9457343 chr6:158740567 A/G cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs12188164 0.965 rs11739543 chr5:443676 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs240764 0.604 rs9404016 chr6:101177728 G/A cg09795085 chr6:101329169 ASCC3 0.43 6.18 0.32 1.86e-9 Neuroticism; LUSC cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.46 -6.09 -0.32 3.12e-9 Renal function-related traits (BUN); LUSC cis rs9463078 0.838 rs2396373 chr6:44983134 G/A cg25276700 chr6:44698697 NA -0.29 -5.72 -0.3 2.31e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9300255 0.509 rs641760 chr12:123518866 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.4 -6.37 -0.33 6.33e-10 Neutrophil percentage of white cells; LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC trans rs853679 0.546 rs34295134 chr6:27828151 T/A cg01620082 chr3:125678407 NA -0.7 -6.96 -0.36 1.81e-11 Depression; LUSC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg08683831 chr4:1404607 NA 0.35 5.94 0.31 7.27e-9 Obesity-related traits; LUSC cis rs4356932 0.790 rs6848620 chr4:76973549 G/C cg00809888 chr4:76862425 NAAA 0.35 5.82 0.3 1.37e-8 Blood protein levels; LUSC cis rs61931739 0.534 rs10844840 chr12:34364517 C/T cg06521331 chr12:34319734 NA -0.42 -6.59 -0.34 1.76e-10 Morning vs. evening chronotype; LUSC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg20684491 chr1:25596433 NA -0.36 -5.69 -0.3 2.73e-8 Erythrocyte sedimentation rate; LUSC cis rs8179 1.000 rs4272 chr7:92236829 C/T cg15732164 chr7:92237376 CDK6 0.49 6.98 0.36 1.62e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg25817165 chr18:72167213 CNDP2 -0.75 -9.1 -0.45 8.37e-18 Refractive error; LUSC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg01097406 chr16:89675127 NA -0.35 -7.04 -0.36 1.07e-11 Vitiligo; LUSC cis rs72772090 0.539 rs3334 chr5:96115085 G/C cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -6.56 -0.34 2.04e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg00071950 chr4:10020882 SLC2A9 -0.54 -8.33 -0.41 2.14e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg07636037 chr3:49044803 WDR6 -0.68 -8.58 -0.43 3.52e-16 Menarche (age at onset); LUSC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.57 0.34 1.94e-10 Tonsillectomy; LUSC cis rs7582180 0.627 rs4407265 chr2:101005846 C/G cg08017756 chr2:100939284 LONRF2 -0.43 -7.99 -0.4 2.18e-14 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg02475777 chr4:1388615 CRIPAK 0.39 6.16 0.32 2.14e-9 Longevity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21489753 chr5:137667158 CDC25C 0.4 6.12 0.32 2.62e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1670533 1.000 rs2045068 chr4:1052212 G/A cg19318889 chr4:1322082 MAEA 0.43 5.7 0.3 2.66e-8 Recombination rate (females); LUSC cis rs9815354 0.537 rs73073272 chr3:42022446 G/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg06784218 chr1:46089804 CCDC17 0.54 10.59 0.5 8.43e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg18225595 chr11:63971243 STIP1 0.63 10.62 0.5 6.96e-23 Platelet count; LUSC cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg22681709 chr2:178499509 PDE11A -0.51 -9.18 -0.45 4.62e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg11608241 chr8:8085544 FLJ10661 0.41 6.19 0.32 1.76e-9 Mood instability; LUSC trans rs7819412 0.527 rs7821914 chr8:10805015 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.53 -0.38 4.72e-13 Triglycerides; LUSC cis rs4319547 0.737 rs10846920 chr12:122943231 C/T cg23029597 chr12:123009494 RSRC2 -0.68 -9.15 -0.45 5.6e-18 Body mass index; LUSC cis rs9952991 0.941 rs2847280 chr18:12779342 A/G cg23598886 chr18:12777645 NA 0.65 6.6 0.34 1.61e-10 Inflammatory skin disease; LUSC cis rs2073300 1.000 rs6137967 chr20:23447108 A/T cg09953122 chr20:23471693 CST8 0.69 5.85 0.3 1.17e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg16624210 chr5:671434 TPPP 0.49 6.12 0.32 2.58e-9 Lung disease severity in cystic fibrosis; LUSC cis rs1865760 1.000 rs7739966 chr6:25906040 T/C cg16482183 chr6:26056742 HIST1H1C 0.44 6.59 0.34 1.72e-10 Height; LUSC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg18512352 chr11:47633146 NA -0.46 -9.21 -0.45 3.73e-18 Subjective well-being; LUSC cis rs3813567 0.759 rs12148319 chr15:78956192 A/G cg24631222 chr15:78858424 CHRNA5 0.52 5.87 0.31 1.05e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg26850624 chr5:429559 AHRR 0.34 6.07 0.32 3.55e-9 Cystic fibrosis severity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22870899 chr14:65347138 NA 0.45 6.16 0.32 2.08e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs453301 0.631 rs17700611 chr8:8793654 A/G cg15556689 chr8:8085844 FLJ10661 -0.59 -9.27 -0.45 2.34e-18 Joint mobility (Beighton score); LUSC cis rs9653442 0.564 rs13013594 chr2:100784190 A/G cg22139774 chr2:100720529 AFF3 -0.41 -7.12 -0.36 6.51e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2820315 0.867 rs2820319 chr1:201878650 G/A cg10061532 chr1:201886748 LMOD1 0.27 6.19 0.32 1.73e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.49 -8.47 -0.42 8.14e-16 Lymphocyte counts; LUSC cis rs7100689 0.555 rs1934146 chr10:82062121 C/A cg00277334 chr10:82204260 NA -0.58 -8.65 -0.43 2.21e-16 Post bronchodilator FEV1; LUSC cis rs10911363 0.573 rs2702181 chr1:183516985 T/A cg09173681 chr1:183549694 NCF2 0.63 11.18 0.52 7.23e-25 Systemic lupus erythematosus; LUSC cis rs2227930 0.528 rs6786320 chr3:142111273 G/C cg16271453 chr3:142027066 XRN1 -0.55 -9.78 -0.47 5.09e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs10979 1.000 rs1054752 chr6:143890097 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg02569458 chr12:86230093 RASSF9 0.58 9.82 0.47 3.54e-20 Major depressive disorder; LUSC cis rs59104589 0.617 rs16842449 chr2:242354979 C/T cg14842376 chr2:242211374 HDLBP 0.57 6.6 0.34 1.61e-10 Fibrinogen levels; LUSC cis rs637571 0.510 rs10750772 chr11:65577427 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.39 -6.91 -0.35 2.42e-11 Eosinophil percentage of white cells; LUSC trans rs11723530 0.538 rs10025523 chr4:170813307 T/C cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.16 -0.32 2.13e-9 Myopia (pathological); LUSC cis rs5769765 0.704 rs138837 chr22:50180714 A/G cg26441486 chr22:50317300 CRELD2 0.42 6.58 0.34 1.8e-10 Schizophrenia; LUSC cis rs7177699 0.557 rs8027833 chr15:79112837 T/C cg15571903 chr15:79123663 NA 0.31 5.86 0.31 1.1e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg06008330 chr7:65541103 ASL 0.41 6.55 0.34 2.22e-10 Aortic root size; LUSC cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.16 0.49 2.68e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1499972 0.941 rs62263116 chr3:117622719 T/G cg07612923 chr3:117604196 NA 0.61 5.67 0.3 3.1e-8 Schizophrenia; LUSC cis rs6554196 0.525 rs2192158 chr4:55505360 C/T cg18836493 chr4:55524333 KIT 0.39 6.52 0.34 2.54e-10 Monocyte count; LUSC cis rs7903847 0.642 rs9887991 chr10:99159634 T/C cg20016023 chr10:99160130 RRP12 -0.31 -7.82 -0.39 6.85e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg17143192 chr8:8559678 CLDN23 0.56 7.83 0.39 6.51e-14 Obesity-related traits; LUSC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg04369109 chr6:150039330 LATS1 -0.59 -8.54 -0.42 4.86e-16 Lung cancer; LUSC trans rs62055045 0.528 rs9935288 chr16:71552741 T/C cg15281710 chr15:96890452 NA -0.42 -6.3 -0.33 9.27e-10 Schizophrenia; LUSC cis rs7208859 0.623 rs9895785 chr17:29107708 C/T cg13385521 chr17:29058706 SUZ12P -0.67 -6.26 -0.32 1.16e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9467711 0.591 rs16891235 chr6:26017542 T/C cg16898833 chr6:26189333 HIST1H4D 0.68 6.34 0.33 7.25e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs12368653 0.544 rs11172304 chr12:58097862 T/C cg12615879 chr12:58013172 SLC26A10 0.29 6.74 0.35 7.01e-11 Multiple sclerosis; LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg17541715 chr7:1216824 NA -0.39 -6.18 -0.32 1.92e-9 Longevity;Endometriosis; LUSC cis rs909002 0.830 rs7542583 chr1:32110813 A/G cg01639898 chr1:32083012 HCRTR1 0.32 7.79 0.39 8.8e-14 Intelligence (multi-trait analysis); LUSC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg22029157 chr1:209979665 IRF6 0.74 9.54 0.46 3.12e-19 Cleft lip with or without cleft palate; LUSC cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg10172584 chr19:19639581 YJEFN3 -0.5 -5.84 -0.3 1.23e-8 Bipolar disorder; LUSC cis rs7824557 0.564 rs2736290 chr8:11234298 C/T cg21775007 chr8:11205619 TDH -0.67 -10.67 -0.5 4.64e-23 Retinal vascular caliber; LUSC cis rs4843185 0.637 rs4143866 chr16:85716366 A/G cg00168118 chr16:85669675 KIAA0182 0.38 5.79 0.3 1.66e-8 Platelet distribution width; LUSC cis rs7107174 0.901 rs2510053 chr11:77959435 T/C cg02023728 chr11:77925099 USP35 0.45 6.87 0.35 3.09e-11 Testicular germ cell tumor; LUSC cis rs9467711 0.659 rs13220261 chr6:26499185 C/T cg09904177 chr6:26538194 HMGN4 -0.79 -6.17 -0.32 1.95e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs208520 0.526 rs7771233 chr6:66819784 A/G cg07460842 chr6:66804631 NA -1.18 -24.54 -0.8 9.75e-77 Exhaled nitric oxide output; LUSC cis rs9532580 0.778 rs34373380 chr13:41244217 T/A cg21288729 chr13:41239152 FOXO1 0.62 9.52 0.46 3.52e-19 Mean corpuscular hemoglobin; LUSC cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.69 0.43 1.62e-16 Motion sickness; LUSC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs7824557 0.564 rs2572400 chr8:11234367 T/G cg21775007 chr8:11205619 TDH -0.67 -10.64 -0.5 6.04e-23 Retinal vascular caliber; LUSC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.44 0.42 1.01e-15 Height; LUSC cis rs28647808 0.881 rs57394597 chr9:136261030 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs950169 0.810 rs2879976 chr15:85109578 G/A cg11189052 chr15:85197271 WDR73 0.46 5.72 0.3 2.35e-8 Schizophrenia; LUSC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18404041 chr3:52824283 ITIH1 -0.51 -9.73 -0.47 7.44e-20 Bipolar disorder; LUSC cis rs35123781 0.502 rs261532 chr5:138949362 A/C cg26929925 chr5:138714136 SLC23A1 0.47 7.38 0.37 1.27e-12 Schizophrenia; LUSC cis rs6580649 0.825 rs4760611 chr12:48421449 A/G cg24011408 chr12:48396354 COL2A1 0.45 6.05 0.31 3.86e-9 Lung cancer; LUSC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg13206674 chr6:150067644 NUP43 0.5 7.46 0.38 7.55e-13 Lung cancer; LUSC cis rs4622329 0.636 rs7975403 chr12:102288527 G/C cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC cis rs7165170 0.808 rs12915979 chr15:91199025 C/T cg05609160 chr15:91208370 NA -0.4 -5.89 -0.31 9.64e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11890956 chr21:40555474 PSMG1 0.99 18.67 0.71 8.81e-54 Cognitive function; LUSC cis rs11098499 0.644 rs7693919 chr4:120540571 G/A cg24375607 chr4:120327624 NA 0.71 11.31 0.53 2.45e-25 Corneal astigmatism; LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg08888203 chr3:10149979 C3orf24 0.66 8.79 0.43 8.06e-17 Alzheimer's disease; LUSC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg07716408 chr11:68623521 NA -0.31 -5.82 -0.3 1.38e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs1864729 0.748 rs2635138 chr8:98301418 A/G cg08679828 chr8:102218111 ZNF706 0.78 6.53 0.34 2.44e-10 Estradiol plasma levels (breast cancer); LUSC cis rs1577917 0.710 rs9342041 chr6:86280875 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 9.46 0.46 5.76e-19 Response to antipsychotic treatment; LUSC cis rs6977660 0.714 rs10155949 chr7:19834747 T/C cg05791153 chr7:19748676 TWISTNB 0.65 6.68 0.34 1e-10 Thyroid stimulating hormone; LUSC cis rs71403859 0.730 rs17347255 chr16:71587225 C/T cg08717414 chr16:71523259 ZNF19 -0.76 -8.38 -0.42 1.5e-15 Post bronchodilator FEV1; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg13395646 chr4:1353034 KIAA1530 -0.56 -8.58 -0.42 3.74e-16 Obesity-related traits; LUSC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.48 -7.29 -0.37 2.26e-12 Colorectal cancer; LUSC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg23158103 chr7:148848205 ZNF398 -0.41 -6.53 -0.34 2.45e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg03146154 chr1:46216737 IPP 0.55 8.21 0.41 5.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3808502 0.527 rs2736374 chr8:11113828 A/G cg21775007 chr8:11205619 TDH -0.41 -5.82 -0.3 1.39e-8 Neuroticism; LUSC cis rs77633900 0.772 rs78181637 chr15:76672569 A/C cg21673338 chr15:77095150 SCAPER -0.7 -6.1 -0.32 2.99e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs17253792 0.822 rs8013714 chr14:56172286 T/C cg01858014 chr14:56050164 KTN1 -0.71 -6.35 -0.33 6.97e-10 Putamen volume; LUSC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg12751644 chr20:60527061 NA -0.34 -6.0 -0.31 5.25e-9 Body mass index; LUSC cis rs9324022 0.929 rs9635184 chr14:101173056 C/T cg18089426 chr14:101175970 NA 0.48 5.76 0.3 1.93e-8 Plateletcrit; LUSC cis rs7223966 1.000 rs8068603 chr17:61755211 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.33 0.37 1.75e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs8072100 0.754 rs8081717 chr17:45653921 T/A cg25173405 chr17:45401733 C17orf57 0.38 6.05 0.31 3.96e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2055729 0.601 rs12546952 chr8:9744002 G/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.1 -0.32 2.99e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg05283184 chr6:79620031 NA -0.57 -11.79 -0.54 4.8e-27 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg15117754 chr3:10150083 C3orf24 0.44 5.79 0.3 1.59e-8 Alzheimer's disease; LUSC cis rs9733 0.621 rs932054 chr1:150539867 C/G cg04414720 chr1:150670196 GOLPH3L -0.46 -7.0 -0.36 1.44e-11 Tonsillectomy; LUSC cis rs12891047 1.000 rs2235962 chr14:68248281 A/G cg20999565 chr14:68265668 ZFYVE26 0.37 5.67 0.3 3.09e-8 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs11039798 0.844 rs11040177 chr11:48976211 G/C cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs9486715 0.867 rs4839828 chr6:96863326 G/A cg06623918 chr6:96969491 KIAA0776 0.93 17.77 0.7 3.49e-50 Headache; LUSC cis rs10203711 0.966 rs4998692 chr2:239564772 T/G cg14580085 chr2:239553406 NA 0.41 6.96 0.36 1.76e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg06092702 chr1:163392909 NA -0.43 -7.18 -0.37 4.62e-12 Motion sickness; LUSC cis rs4631830 0.720 rs2012677 chr10:51504797 T/A cg20129853 chr10:51489980 NA -0.36 -7.56 -0.38 3.84e-13 Prostate-specific antigen levels; LUSC cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg10518543 chr12:38710700 ALG10B 0.41 5.78 0.3 1.74e-8 Drug-induced liver injury (flucloxacillin); LUSC cis rs2120243 0.591 rs9871290 chr3:157099591 A/G cg01018701 chr3:157155998 VEPH1;PTX3 0.36 5.69 0.3 2.78e-8 Hepatocellular carcinoma in hepatitis B infection; LUSC cis rs2730245 0.636 rs2657382 chr7:158650941 G/A cg11984989 chr7:158649758 WDR60 1.04 20.72 0.75 6.58e-62 Height; LUSC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg20243544 chr17:37824526 PNMT 0.41 6.25 0.32 1.23e-9 Asthma; LUSC cis rs1023500 0.596 rs5751204 chr22:42433801 C/T cg15557168 chr22:42548783 NA -0.39 -5.85 -0.3 1.17e-8 Schizophrenia; LUSC cis rs6918586 0.658 rs198826 chr6:26121153 A/G cg17691542 chr6:26056736 HIST1H1C -0.4 -5.98 -0.31 5.58e-9 Schizophrenia; LUSC trans rs853679 0.599 rs149943 chr6:28002388 G/A cg01620082 chr3:125678407 NA -0.61 -6.92 -0.35 2.35e-11 Depression; LUSC cis rs11031096 0.628 rs10835735 chr11:4211865 G/C cg18678763 chr11:4115507 RRM1 -0.41 -5.72 -0.3 2.31e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs72674100 1.000 rs72880546 chr4:97973701 T/C cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7589342 0.899 rs11885225 chr2:106486548 T/C cg14210321 chr2:106509881 NCK2 -0.55 -8.36 -0.42 1.71e-15 Addiction; LUSC cis rs977987 0.836 rs4888376 chr16:75322573 T/C cg03315344 chr16:75512273 CHST6 0.47 8.59 0.43 3.39e-16 Dupuytren's disease; LUSC cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg05347473 chr6:146136440 FBXO30 -0.47 -7.87 -0.4 5.09e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs9650657 0.769 rs1968400 chr8:10615431 G/C cg15556689 chr8:8085844 FLJ10661 -0.4 -6.01 -0.31 4.77e-9 Neuroticism; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20141549 chr3:51534298 VPRBP 0.39 6.08 0.32 3.3e-9 Triglycerides; LUSC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg18190219 chr22:46762943 CELSR1 -0.54 -6.02 -0.31 4.61e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg20821713 chr7:1055600 C7orf50 -0.46 -7.52 -0.38 5.06e-13 Longevity;Endometriosis; LUSC trans rs4596713 0.508 rs35490502 chr9:71747895 T/A cg25283916 chr1:242222868 NA -0.32 -6.71 -0.34 8.55e-11 Headache; LUSC cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg23583168 chr7:148888333 NA -0.87 -16.33 -0.67 1.78e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg13047869 chr3:10149882 C3orf24 -0.52 -7.71 -0.39 1.47e-13 Alzheimer's disease; LUSC cis rs1153858 1.000 rs2467858 chr15:45711492 A/G cg14582100 chr15:45693742 SPATA5L1 0.56 10.09 0.48 4.35e-21 Homoarginine levels; LUSC cis rs2404602 0.647 rs12440965 chr15:76958591 G/A cg23625390 chr15:77176239 SCAPER -0.65 -9.78 -0.47 4.88e-20 Blood metabolite levels; LUSC cis rs250677 0.958 rs36078 chr5:148430567 G/A cg23229984 chr5:148520753 ABLIM3 0.38 5.73 0.3 2.22e-8 Breast cancer; LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs10088262 0.629 rs7827665 chr8:124804190 G/A cg20713898 chr8:124780851 FAM91A1 -0.54 -7.52 -0.38 5.13e-13 Pancreatic cancer; LUSC cis rs12310956 0.532 rs11052930 chr12:33964824 A/G cg06521331 chr12:34319734 NA -0.45 -7.2 -0.37 3.95e-12 Morning vs. evening chronotype; LUSC cis rs2073300 1.000 rs6114126 chr20:23452127 A/T cg09953122 chr20:23471693 CST8 -0.72 -6.61 -0.34 1.54e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6456156 0.586 rs7746628 chr6:167483235 A/G cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg04362960 chr10:104952993 NT5C2 0.68 9.95 0.48 1.35e-20 Arsenic metabolism; LUSC cis rs3812831 0.695 rs8000778 chr13:114944310 T/C cg15896084 chr13:114927664 NA 0.4 7.34 0.37 1.66e-12 Schizophrenia; LUSC cis rs1865721 0.656 rs724765 chr18:73139794 A/G cg26385618 chr18:73139727 C18orf62 -0.46 -8.52 -0.42 5.69e-16 Intelligence; LUSC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg11812906 chr14:75593930 NEK9 0.65 11.13 0.52 1.09e-24 Height; LUSC cis rs1559088 0.947 rs7256182 chr19:33558591 G/A cg17764715 chr19:33622953 WDR88 0.59 7.95 0.4 2.96e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs300703 0.816 rs434818 chr2:200477 G/A cg21211680 chr2:198530 NA 0.68 7.31 0.37 1.98e-12 Blood protein levels; LUSC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg15110403 chr19:17392923 ANKLE1 0.51 7.25 0.37 2.99e-12 Systemic lupus erythematosus; LUSC trans rs9393777 0.720 rs35212793 chr6:26998693 T/C cg06606381 chr12:133084897 FBRSL1 -0.61 -6.44 -0.33 4.28e-10 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg07092213 chr7:1199455 ZFAND2A -0.54 -8.46 -0.42 8.63e-16 Longevity;Endometriosis; LUSC cis rs9837602 1.000 rs9851645 chr3:99767409 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.01 -0.31 4.82e-9 Breast cancer; LUSC trans rs8030485 0.571 rs4778904 chr15:79418856 A/C cg16586880 chr8:140854244 TRAPPC9 -0.37 -6.15 -0.32 2.26e-9 Left ventricle wall thickness; LUSC cis rs611744 0.647 rs2848620 chr8:109249551 G/T cg21045802 chr8:109455806 TTC35 0.43 6.57 0.34 1.92e-10 Dupuytren's disease; LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg01368799 chr11:117014884 PAFAH1B2 0.47 6.12 0.32 2.58e-9 Blood protein levels; LUSC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.86 -13.91 -0.61 5.25e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7939886 0.920 rs11227158 chr11:55843795 A/G cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs6424115 0.830 rs2501423 chr1:24199026 A/C cg15997130 chr1:24165203 NA 0.53 8.73 0.43 1.25e-16 Immature fraction of reticulocytes; LUSC cis rs193541 0.501 rs3943379 chr5:122056137 A/G cg19077854 chr5:122220652 SNX24 0.33 6.58 0.34 1.77e-10 Glucose homeostasis traits; LUSC cis rs9322817 0.669 rs4079063 chr6:105266118 A/G cg02098413 chr6:105308735 HACE1 -0.27 -5.65 -0.3 3.5e-8 Thyroid stimulating hormone; LUSC cis rs11608355 1.000 rs9669684 chr12:109860644 C/T cg05360138 chr12:110035743 NA 0.47 6.35 0.33 6.87e-10 Neuroticism; LUSC trans rs9784649 0.891 rs57762467 chr5:25025700 C/T cg08600765 chr20:34638493 LOC647979 -0.6 -6.89 -0.35 2.84e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs17095355 1.000 rs2122517 chr10:111754787 C/T cg00817464 chr10:111662876 XPNPEP1 -0.63 -7.99 -0.4 2.23e-14 Biliary atresia; LUSC cis rs10498514 1.000 rs117727667 chr14:65028278 T/A cg25134081 chr14:64931936 AKAP5 0.95 6.82 0.35 4.4e-11 Cognitive performance; LUSC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg00745463 chr17:30367425 LRRC37B -0.79 -9.15 -0.45 5.71e-18 Hip circumference adjusted for BMI; LUSC cis rs35146811 0.586 rs34213597 chr7:99591021 C/T cg22906224 chr7:99728672 NA 0.44 5.73 0.3 2.22e-8 Coronary artery disease; LUSC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs10170846 0.530 rs56353541 chr2:223421187 G/C cg25565276 chr2:223520875 FARSB 0.68 9.69 0.47 9.64e-20 Schizophrenia (inflammation and infection response interaction); LUSC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg10018233 chr7:150070692 REPIN1 0.39 6.44 0.33 4.13e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg04944784 chr2:26401820 FAM59B 0.76 11.29 0.53 2.89e-25 Gut microbiome composition (summer); LUSC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg16624210 chr5:671434 TPPP 0.5 6.25 0.32 1.27e-9 Lung disease severity in cystic fibrosis; LUSC cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg18681998 chr4:17616180 MED28 0.86 16.05 0.66 2.21e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11098499 0.820 rs2389885 chr4:120533931 C/T cg09307838 chr4:120376055 NA 0.73 10.42 0.5 3.39e-22 Corneal astigmatism; LUSC trans rs6598955 0.671 rs11247880 chr1:26568926 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.62 -0.43 2.67e-16 Obesity-related traits; LUSC cis rs9325144 0.600 rs10748442 chr12:38732939 A/T cg26384229 chr12:38710491 ALG10B 0.6 9.47 0.46 5.28e-19 Morning vs. evening chronotype; LUSC cis rs7095944 0.614 rs10901818 chr10:126449428 G/A cg08799069 chr10:126477246 METTL10 -0.42 -6.56 -0.34 2.04e-10 Asthma; LUSC cis rs601339 1.000 rs601339 chr12:123174743 A/G cg11919336 chr12:123188078 GPR109A 0.44 6.58 0.34 1.78e-10 Adiponectin levels; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg18110333 chr6:292329 DUSP22 -0.72 -11.76 -0.54 5.81e-27 Menopause (age at onset); LUSC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg21770322 chr7:97807741 LMTK2 0.4 6.85 0.35 3.48e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1549118 0.595 rs7160485 chr14:78332734 C/G cg02301378 chr14:78227641 SNW1;C14orf178 -0.43 -5.74 -0.3 2.12e-8 Resting heart rate; LUSC trans rs459571 1.000 rs459571 chr9:136912626 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.43 -6.21 -0.32 1.61e-9 Platelet distribution width; LUSC cis rs1023500 0.596 rs133350 chr22:42429049 A/G cg15557168 chr22:42548783 NA -0.4 -6.13 -0.32 2.49e-9 Schizophrenia; LUSC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg24578937 chr1:2090814 PRKCZ 0.46 10.44 0.5 2.8e-22 Height; LUSC cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg26384229 chr12:38710491 ALG10B 0.87 15.08 0.64 1.52e-39 Bladder cancer; LUSC cis rs11676348 0.772 rs11687200 chr2:218944615 A/G cg06547715 chr2:218990976 CXCR2 0.3 5.69 0.3 2.75e-8 Ulcerative colitis; LUSC cis rs12497850 1.000 rs6788650 chr3:48749543 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.39 0.42 1.43e-15 Parkinson's disease; LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg23758822 chr17:41437982 NA 1.03 19.58 0.73 2.08e-57 Menopause (age at onset); LUSC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg27165867 chr14:105738592 BRF1 -0.51 -7.49 -0.38 6.18e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs4595586 0.545 rs12823487 chr12:39391286 A/G cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs2692947 0.794 rs2692893 chr2:96756547 C/T cg22654517 chr2:96458247 NA 0.33 6.13 0.32 2.54e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9303542 0.625 rs9904760 chr17:46575031 C/T cg09704116 chr17:46666958 LOC404266 -0.3 -5.84 -0.3 1.25e-8 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs9487051 0.735 rs455839 chr6:109524221 G/A cg00509249 chr6:109615579 CCDC162 -0.33 -5.76 -0.3 1.92e-8 Reticulocyte fraction of red cells; LUSC cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg21535247 chr6:8435926 SLC35B3 0.58 9.01 0.44 1.59e-17 Motion sickness; LUSC cis rs826838 0.933 rs980573 chr12:39127811 T/C cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07012702 chr16:25118409 NA -0.48 -6.34 -0.33 7.49e-10 Hepatitis; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg08888203 chr3:10149979 C3orf24 0.6 8.3 0.41 2.68e-15 Alzheimer's disease; LUSC cis rs936229 0.861 rs11634474 chr15:75116184 C/G cg14664628 chr15:75095509 CSK -0.99 -16.84 -0.68 1.61e-46 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7633857 0.512 rs13098529 chr3:160657053 A/G cg03342759 chr3:160939853 NMD3 -0.43 -6.35 -0.33 7.13e-10 Educational attainment (years of education); LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg16405210 chr4:1374714 KIAA1530 -0.84 -13.8 -0.6 1.35e-34 Longevity; LUSC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg05535760 chr7:792225 HEATR2 0.94 9.79 0.47 4.7e-20 Cerebrospinal P-tau181p levels; LUSC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg07212818 chr11:638076 DRD4 -0.33 -5.74 -0.3 2.13e-8 Systemic lupus erythematosus; LUSC cis rs77741769 0.571 rs12580949 chr12:121298164 A/G cg02419362 chr12:121203948 SPPL3 0.46 8.5 0.42 6.39e-16 Mean corpuscular volume; LUSC cis rs7474896 0.537 rs598857 chr10:38302926 A/G cg25427524 chr10:38739819 LOC399744 0.43 5.75 0.3 2e-8 Obesity (extreme); LUSC cis rs77106637 1.000 rs76793820 chr11:72619860 G/A cg03713592 chr11:72463424 ARAP1 0.84 9.87 0.48 2.41e-20 Type 2 diabetes; LUSC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg06640241 chr16:89574553 SPG7 0.65 9.72 0.47 7.97e-20 Multiple myeloma (IgH translocation); LUSC trans rs7538876 0.787 rs57142672 chr1:17744536 A/G cg13009662 chr5:127419527 SLC12A2;FLJ33630 0.41 5.99 0.31 5.49e-9 Basal cell carcinoma; LUSC trans rs11098499 0.754 rs2036856 chr4:120249288 G/A cg25214090 chr10:38739885 LOC399744 0.44 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs4595586 0.545 rs2197941 chr12:39402223 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.06 0.36 9.57e-12 Morning vs. evening chronotype; LUSC cis rs4845570 0.920 rs11810571 chr1:151762308 C/G cg07092448 chr1:151763213 TDRKH 1.26 16.59 0.67 1.69e-45 Coronary artery disease; LUSC cis rs9788682 0.747 rs2656074 chr15:78741384 T/C cg24631222 chr15:78858424 CHRNA5 -0.66 -8.64 -0.43 2.3e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg04450456 chr4:17643702 FAM184B 0.4 6.85 0.35 3.65e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12579753 1.000 rs66646148 chr12:82248520 T/G cg07988820 chr12:82153109 PPFIA2 -0.41 -5.74 -0.3 2.13e-8 Resting heart rate; LUSC cis rs4077515 0.901 rs11791262 chr9:139271919 C/T cg14169450 chr9:139327907 INPP5E 0.42 7.53 0.38 4.81e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg24642439 chr20:33292090 TP53INP2 0.53 8.1 0.41 1.02e-14 Coronary artery disease; LUSC cis rs6835098 0.961 rs17322893 chr4:174122556 A/G cg27433088 chr4:174089019 GALNT7 -0.39 -5.75 -0.3 2.04e-8 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs7264396 0.887 rs2236159 chr20:34102189 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.58 -0.34 1.82e-10 Total cholesterol levels; LUSC cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg00071950 chr4:10020882 SLC2A9 -0.49 -8.17 -0.41 6.57e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs61931739 0.500 rs7296061 chr12:34435009 A/G cg13010199 chr12:38710504 ALG10B -0.65 -10.3 -0.49 8.48e-22 Morning vs. evening chronotype; LUSC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg07636037 chr3:49044803 WDR6 0.89 13.9 0.61 5.5e-35 Menarche (age at onset); LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.58 0.38 3.4e-13 Bipolar disorder; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg00149659 chr3:10157352 C3orf10 0.96 14.74 0.63 3.24e-38 Alzheimer's disease; LUSC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11890956 chr21:40555474 PSMG1 -0.75 -11.67 -0.54 1.3e-26 Menarche (age at onset); LUSC cis rs7264396 0.790 rs6060518 chr20:34217309 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.72 -0.47 7.67e-20 Total cholesterol levels; LUSC cis rs11122272 0.766 rs2790872 chr1:231540543 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.87 -0.48 2.41e-20 Hemoglobin concentration; LUSC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.42 6.13 0.32 2.46e-9 Schizophrenia; LUSC cis rs10144321 0.729 rs724392 chr14:100832252 C/T cg14882082 chr14:100845427 WDR25 -0.42 -7.98 -0.4 2.37e-14 Menarche (age at onset); LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg10150615 chr22:24372951 LOC391322 -0.43 -7.13 -0.36 6.06e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9420 0.961 rs576859 chr11:57480623 A/C cg23127183 chr11:57508653 C11orf31 0.48 7.29 0.37 2.3e-12 Schizophrenia; LUSC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.71 -0.34 8.22e-11 Total body bone mineral density; LUSC cis rs4474465 0.850 rs10899536 chr11:78216992 C/A cg27205649 chr11:78285834 NARS2 0.52 6.0 0.31 5.01e-9 Alzheimer's disease (survival time); LUSC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg00152838 chr16:24741724 TNRC6A -0.48 -6.01 -0.31 4.82e-9 Intelligence (multi-trait analysis); LUSC cis rs977987 0.806 rs11640674 chr16:75394944 A/G cg03315344 chr16:75512273 CHST6 0.48 9.26 0.45 2.6e-18 Dupuytren's disease; LUSC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg08680598 chr22:49984980 NA -0.32 -5.91 -0.31 8.61e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs35883536 0.566 rs4908086 chr1:101088124 C/T cg06223162 chr1:101003688 GPR88 0.39 6.79 0.35 5.02e-11 Monocyte count; LUSC cis rs9902453 0.845 rs58575982 chr17:28221776 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 10.19 0.49 2.14e-21 Coffee consumption (cups per day); LUSC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg23172400 chr8:95962367 TP53INP1 -0.37 -7.46 -0.38 7.71e-13 Type 2 diabetes; LUSC cis rs2486288 0.656 rs8024620 chr15:45574329 C/T cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.99 -0.52 3.32e-24 Glomerular filtration rate; LUSC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9309473 0.950 rs13431529 chr2:73876041 G/C cg20560298 chr2:73613845 ALMS1 -0.43 -6.15 -0.32 2.22e-9 Metabolite levels; LUSC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg23625390 chr15:77176239 SCAPER -0.44 -6.84 -0.35 3.79e-11 Blood metabolite levels; LUSC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.59 -0.6 8.89e-34 Chronic sinus infection; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25581932 chr17:7892150 NA -0.49 -6.52 -0.34 2.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg23093090 chr10:104574429 C10orf26 -0.39 -7.35 -0.37 1.51e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs240768 1.000 rs240166 chr6:101037678 T/C cg12253828 chr6:101329408 ASCC3 0.83 5.7 0.3 2.7e-8 Economic and political preferences (immigration/crime); LUSC trans rs1171606 0.731 rs1171652 chr10:61449512 A/G cg14119616 chr11:17099403 RPS13 -0.4 -6.08 -0.32 3.24e-9 Acylcarnitine levels; LUSC cis rs7584330 0.554 rs6760913 chr2:238400702 C/T cg14458575 chr2:238380390 NA 0.68 8.28 0.41 2.94e-15 Prostate cancer; LUSC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg00933542 chr6:150070202 PCMT1 0.3 6.01 0.31 4.73e-9 Lung cancer; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg23978390 chr7:1156363 C7orf50 0.54 7.67 0.39 1.91e-13 Longevity;Endometriosis; LUSC cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg12011299 chr4:100065546 ADH4 -0.7 -10.79 -0.51 1.71e-23 Alcohol dependence; LUSC cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.78 0.6 1.67e-34 Chronic sinus infection; LUSC cis rs13082711 0.911 rs35532045 chr3:27515870 A/G cg02860705 chr3:27208620 NA 0.47 7.91 0.4 3.88e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs12545109 0.879 rs893234 chr8:57363885 G/A cg09654669 chr8:57350985 NA -0.56 -7.43 -0.38 8.93e-13 Obesity-related traits; LUSC cis rs11997175 0.624 rs17778980 chr8:33700926 T/C ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.2e-10 Body mass index; LUSC cis rs9948 0.655 rs6576981 chr2:97394406 G/C cg01990225 chr2:97406019 LMAN2L -1.09 -8.15 -0.41 7.59e-15 Erectile dysfunction and prostate cancer treatment; LUSC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg18230493 chr5:56204884 C5orf35 0.93 13.5 0.59 1.95e-33 Initial pursuit acceleration; LUSC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg04733989 chr22:42467013 NAGA 0.61 9.48 0.46 4.84e-19 Schizophrenia; LUSC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg02269571 chr22:50332266 NA -0.55 -8.47 -0.42 7.91e-16 Schizophrenia; LUSC cis rs6541297 1.000 rs4846836 chr1:230281316 G/A cg20703242 chr1:230279135 GALNT2 0.54 8.41 0.42 1.17e-15 Coronary artery disease; LUSC cis rs7267979 1.000 rs2482911 chr20:25395528 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.78 -0.7 2.97e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12477438 0.834 rs1563107 chr2:99701276 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.63 8.48 0.42 7.34e-16 Chronic sinus infection; LUSC cis rs7113850 0.541 rs56679749 chr11:24235649 G/A ch.11.24196551F chr11:24239977 NA 1.0 9.09 0.45 9.2e-18 Bone fracture in osteoporosis; LUSC cis rs4595586 0.545 rs17546375 chr12:39407248 C/A cg13010199 chr12:38710504 ALG10B 0.44 6.34 0.33 7.66e-10 Morning vs. evening chronotype; LUSC cis rs3106136 0.967 rs72665658 chr4:95144761 C/T cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.12 -0.32 2.68e-9 Capecitabine sensitivity; LUSC cis rs6582630 0.593 rs12816835 chr12:38533304 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.52 -0.34 2.66e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs10493773 0.630 rs3753790 chr1:86174772 T/C cg17807903 chr1:86174739 ZNHIT6 -0.54 -14.59 -0.62 1.18e-37 Urate levels in overweight individuals; LUSC cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg23788917 chr6:8435910 SLC35B3 0.48 7.23 0.37 3.21e-12 Motion sickness; LUSC trans rs208520 0.690 rs12213928 chr6:66762978 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.66 0.67 8.34e-46 Exhaled nitric oxide output; LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg25767906 chr1:53392781 SCP2 0.48 8.69 0.43 1.67e-16 Monocyte count; LUSC cis rs896854 0.573 rs11996455 chr8:95853708 G/A cg23172400 chr8:95962367 TP53INP1 -0.35 -7.0 -0.36 1.38e-11 Type 2 diabetes; LUSC cis rs7119 0.651 rs12909292 chr15:77837982 G/T cg27398640 chr15:77910606 LINGO1 -0.28 -5.66 -0.3 3.28e-8 Type 2 diabetes; LUSC cis rs9314323 0.767 rs10866848 chr8:26208209 G/C cg11498726 chr8:26250323 BNIP3L -0.43 -6.05 -0.31 3.96e-9 Red cell distribution width; LUSC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.67 0.39 1.91e-13 Crohn's disease; LUSC cis rs2301888 1.000 rs2240335 chr1:17674537 G/T cg01790353 chr1:17674483 PADI4 0.36 6.99 0.36 1.51e-11 Rheumatoid arthritis; LUSC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.03 0.36 1.18e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs16854884 0.710 rs1530479 chr3:143819653 C/T cg01302019 chr3:143689584 C3orf58 -0.35 -5.96 -0.31 6.5e-9 Economic and political preferences (feminism/equality); LUSC cis rs6138458 0.743 rs3746330 chr20:24999795 A/G cg26195577 chr20:24973756 C20orf3 0.76 11.68 0.54 1.16e-26 Blood protein levels; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg00684032 chr4:1343700 KIAA1530 0.37 6.5 0.34 2.89e-10 Obesity-related traits; LUSC cis rs708547 0.647 rs1718878 chr4:57876955 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.59 0.38 3.31e-13 Response to bleomycin (chromatid breaks); LUSC cis rs4363385 0.714 rs4845329 chr1:152974454 G/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg03388025 chr16:89894329 SPIRE2 0.35 7.28 0.37 2.47e-12 Vitiligo; LUSC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg07741184 chr6:167504864 NA -0.36 -6.59 -0.34 1.73e-10 Crohn's disease; LUSC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg16049864 chr8:95962084 TP53INP1 -0.56 -10.61 -0.5 7.67e-23 Type 2 diabetes; LUSC cis rs4727027 0.704 rs12704073 chr7:148905067 G/A cg23583168 chr7:148888333 NA -0.9 -17.6 -0.69 1.57e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg27094323 chr7:1216898 NA -0.45 -7.75 -0.39 1.11e-13 Longevity;Endometriosis; LUSC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.75 -0.8 1.56e-77 Height; LUSC cis rs3008870 0.755 rs2815380 chr1:67510857 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.64 -9.81 -0.47 3.99e-20 Lymphocyte percentage of white cells; LUSC cis rs9457247 0.756 rs1811123 chr6:167403443 T/C cg07741184 chr6:167504864 NA 0.36 6.43 0.33 4.32e-10 Crohn's disease; LUSC trans rs7824557 0.767 rs2060463 chr8:11161610 T/G cg06636001 chr8:8085503 FLJ10661 0.52 7.79 0.39 8.75e-14 Retinal vascular caliber; LUSC cis rs2834081 0.536 rs11702285 chr21:34474294 G/A cg10915739 chr21:34405733 NA 0.37 6.38 0.33 5.96e-10 Sum eosinophil basophil counts; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg13560548 chr3:10150139 C3orf24 0.54 7.52 0.38 5.24e-13 Alzheimer's disease; LUSC cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg00033643 chr7:134001901 SLC35B4 0.42 6.17 0.32 2e-9 Mean platelet volume; LUSC cis rs17102423 0.594 rs1270074 chr14:65564856 T/C cg11161011 chr14:65562177 MAX -0.72 -11.05 -0.52 2.16e-24 Obesity-related traits; LUSC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.01e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg14582100 chr15:45693742 SPATA5L1 0.59 10.79 0.51 1.81e-23 Homoarginine levels; LUSC cis rs9811920 0.809 rs923472 chr3:99758029 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -6.88 -0.35 2.95e-11 Axial length; LUSC cis rs7582180 0.629 rs74177696 chr2:100938481 C/G cg12002119 chr2:101014098 CHST10 0.35 5.75 0.3 1.98e-8 Intelligence (multi-trait analysis); LUSC cis rs3733418 0.929 rs4690797 chr4:165908505 G/C cg11630554 chr4:165878136 TRIM61;C4orf39 -0.51 -5.83 -0.3 1.34e-8 Obesity-related traits; LUSC cis rs2204008 0.840 rs7957966 chr12:37953629 A/G cg13010199 chr12:38710504 ALG10B -0.61 -9.46 -0.46 5.53e-19 Bladder cancer; LUSC cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg04450456 chr4:17643702 FAM184B 0.36 6.01 0.31 4.95e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg00071950 chr4:10020882 SLC2A9 -0.58 -10.01 -0.48 8.56e-21 Bone mineral density; LUSC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg10909506 chr17:38081995 ORMDL3 0.34 5.98 0.31 5.87e-9 Self-reported allergy; LUSC cis rs12474201 0.832 rs6738426 chr2:46986416 A/G cg06386533 chr2:46925753 SOCS5 0.65 9.58 0.46 2.24e-19 Height; LUSC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg22920501 chr2:26401640 FAM59B -0.75 -10.68 -0.5 4.33e-23 Gut microbiome composition (summer); LUSC trans rs6502050 0.799 rs7502533 chr17:80109778 A/G cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg23791538 chr6:167370224 RNASET2 0.41 6.6 0.34 1.64e-10 Crohn's disease; LUSC trans rs8002861 0.935 rs9533678 chr13:44463409 C/T cg12856521 chr11:46389249 DGKZ 0.4 6.24 0.32 1.35e-9 Leprosy; LUSC cis rs12286929 0.639 rs10891802 chr11:115043888 C/A cg04055981 chr11:115044050 NA 0.43 7.84 0.39 6.21e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7481584 0.603 rs399467 chr11:3072348 G/A cg05729581 chr11:3078854 CARS 0.4 5.79 0.3 1.65e-8 Calcium levels; LUSC trans rs8072100 1.000 rs4794016 chr17:45725931 T/A cg04995722 chr7:26192034 NFE2L3 0.37 6.09 0.32 3.03e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs71636778 0.543 rs11810321 chr1:27220521 T/G cg12203394 chr1:27248618 NUDC 0.54 5.68 0.3 2.98e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs3617 0.539 rs9825369 chr3:52953311 T/C cg11645453 chr3:52864694 ITIH4 -0.35 -8.01 -0.4 1.88e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7291412 0.540 rs9627391 chr22:46447097 C/T cg09693106 chr22:46449821 C22orf26;LOC150381 0.4 6.96 0.36 1.8e-11 Dupuytren's disease;Subjective well-being; LUSC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg05585544 chr11:47624801 NA -0.42 -7.34 -0.37 1.67e-12 Subjective well-being; LUSC cis rs6138458 0.626 rs6050261 chr20:25014206 C/T cg26195577 chr20:24973756 C20orf3 0.69 10.48 0.5 2.06e-22 Blood protein levels; LUSC trans rs11098499 0.954 rs17006190 chr4:120418838 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 3.83e-10 Corneal astigmatism; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg09177884 chr7:1199841 ZFAND2A -0.59 -8.19 -0.41 5.54e-15 Longevity;Endometriosis; LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg08677398 chr8:58056175 NA 0.45 6.41 0.33 4.84e-10 Developmental language disorder (linguistic errors); LUSC trans rs236907 0.859 rs10913683 chr1:171758699 T/C cg13482142 chr2:234261155 NA 0.48 6.05 0.31 3.8e-9 Mean platelet volume; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg01802117 chr1:53393560 SCP2 -0.37 -6.01 -0.31 4.95e-9 Monocyte count; LUSC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg11764359 chr7:65958608 NA -0.7 -10.85 -0.51 1.07e-23 Aortic root size; LUSC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg22535103 chr8:58192502 C8orf71 -0.84 -9.29 -0.45 2.11e-18 Developmental language disorder (linguistic errors); LUSC cis rs61931739 0.635 rs1852224 chr12:33963080 A/C cg06521331 chr12:34319734 NA -0.41 -6.73 -0.35 7.34e-11 Morning vs. evening chronotype; LUSC cis rs17155006 0.746 rs435125 chr7:107748934 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg13393036 chr8:95962371 TP53INP1 -0.51 -11.17 -0.52 8.18e-25 Type 2 diabetes; LUSC cis rs796364 0.806 rs79725795 chr2:201083534 C/T cg23649088 chr2:200775458 C2orf69 -0.54 -6.32 -0.33 8.48e-10 Schizophrenia; LUSC cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.86 0.31 1.11e-8 Hip circumference adjusted for BMI; LUSC trans rs9393777 0.920 rs66462181 chr6:27091661 T/C cg06606381 chr12:133084897 FBRSL1 -0.97 -8.2 -0.41 5.16e-15 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.28 0.56 7.3e-29 Motion sickness; LUSC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg07741184 chr6:167504864 NA -0.36 -6.62 -0.34 1.47e-10 Crohn's disease; LUSC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg17376030 chr22:41985996 PMM1 -0.46 -5.87 -0.31 1.03e-8 Vitiligo; LUSC cis rs651907 0.535 rs9830943 chr3:101428899 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.69 10.58 0.5 9.54e-23 Colorectal cancer; LUSC cis rs3770081 1.000 rs12612513 chr2:86301225 G/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.08 -6.95 -0.36 1.88e-11 Facial emotion recognition (sad faces); LUSC cis rs9928842 0.882 rs8048956 chr16:75254966 C/G cg09066997 chr16:75300724 BCAR1 -0.48 -6.09 -0.32 3.07e-9 Alcoholic chronic pancreatitis; LUSC cis rs950776 0.642 rs12905641 chr15:78964362 A/G cg06917634 chr15:78832804 PSMA4 -0.48 -6.95 -0.36 1.94e-11 Sudden cardiac arrest; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg23034840 chr1:205782522 SLC41A1 0.59 8.38 0.42 1.52e-15 Menarche (age at onset); LUSC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg06637938 chr14:75390232 RPS6KL1 0.53 8.46 0.42 8.74e-16 Height; LUSC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg00933542 chr6:150070202 PCMT1 0.32 6.47 0.33 3.51e-10 Lung cancer; LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1729951 0.546 rs361246 chr3:136695667 G/A cg21827317 chr3:136751795 NA 0.38 6.9 0.35 2.63e-11 Neuroticism; LUSC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg00484396 chr16:3507460 NAT15 0.51 7.16 0.36 5.32e-12 Body mass index (adult); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21957174 chr11:64511624 RASGRP2 0.41 6.35 0.33 7.06e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2274273 0.588 rs9919923 chr14:55813899 A/G cg04306507 chr14:55594613 LGALS3 0.48 9.46 0.46 5.53e-19 Protein biomarker; LUSC cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC trans rs72674100 1.000 rs28655295 chr4:97990984 T/G cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs11190604 0.767 rs10883485 chr10:102174805 G/C cg07080220 chr10:102295463 HIF1AN 0.6 7.64 0.39 2.38e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6977660 0.941 rs6953957 chr7:19820560 A/G cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC trans rs3942852 0.910 rs10742829 chr11:48115837 C/T cg03929089 chr4:120376271 NA 0.54 6.23 0.32 1.37e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs6547741 0.844 rs7382 chr2:27873415 G/A cg27432699 chr2:27873401 GPN1 -0.9 -18.17 -0.7 9.02e-52 Oral cavity cancer; LUSC trans rs7726839 0.561 rs4957050 chr5:579066 A/C cg11887960 chr12:57824829 NA 0.51 6.69 0.34 9.16e-11 Obesity-related traits; LUSC cis rs7615316 0.934 rs9869842 chr3:142272314 C/T cg16271453 chr3:142027066 XRN1 -0.35 -6.23 -0.32 1.41e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13353245 chr8:146127515 ZNF250 -0.42 -6.31 -0.33 8.64e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg08677398 chr8:58056175 NA 0.41 5.74 0.3 2.16e-8 Developmental language disorder (linguistic errors); LUSC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg05425664 chr17:57184151 TRIM37 0.51 7.62 0.38 2.63e-13 Intelligence (multi-trait analysis); LUSC cis rs11955175 1.000 rs11951044 chr5:40671189 G/A cg05478818 chr5:40835740 RPL37 0.72 5.95 0.31 6.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10465746 0.967 rs7531537 chr1:84414924 C/T cg10977910 chr1:84465055 TTLL7 0.43 6.38 0.33 5.92e-10 Obesity-related traits; LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg18681998 chr4:17616180 MED28 0.85 15.94 0.66 6.13e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2708977 0.901 rs3731938 chr2:97166204 A/G cg01950434 chr2:97203154 ARID5A -0.54 -8.01 -0.4 1.97e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs6163 0.508 rs12776506 chr10:104532828 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -6.11 -0.32 2.7e-9 Waist circumference;Hip circumference; LUSC trans rs9929218 1.000 rs12443730 chr16:68804342 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.54 -0.53 3.64e-26 Colorectal cancer; LUSC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg20891283 chr12:69753455 YEATS4 0.91 17.45 0.69 6.11e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs73416724 0.925 rs2651201 chr6:43293366 G/A cg26312998 chr6:43337775 ZNF318 -0.54 -6.27 -0.32 1.11e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs17095355 1.000 rs12570612 chr10:111717685 C/T cg00817464 chr10:111662876 XPNPEP1 0.49 6.52 0.34 2.59e-10 Biliary atresia; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.97 -0.31 6.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8038465 0.967 rs3935942 chr15:73971361 C/A cg15420318 chr15:73925796 NPTN 0.42 6.83 0.35 4.07e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10779751 0.922 rs2746638 chr1:11278125 T/C cg08854313 chr1:11322531 MTOR 0.86 14.48 0.62 3.19e-37 Body mass index; LUSC cis rs9300255 0.722 rs67624109 chr12:123824635 C/T cg00376283 chr12:123451042 ABCB9 -0.64 -7.35 -0.37 1.5e-12 Neutrophil percentage of white cells; LUSC cis rs2204008 0.542 rs34770471 chr12:38009613 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.91 0.51 6.74e-24 Bladder cancer; LUSC cis rs8062405 1.000 rs12444171 chr16:28845251 G/A cg09754948 chr16:28834200 ATXN2L 0.41 6.12 0.32 2.63e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs4332037 0.950 rs56403963 chr7:1946130 C/G cg10840412 chr1:235813424 GNG4 0.68 9.13 0.45 6.54e-18 Bipolar disorder; LUSC cis rs10788264 0.504 rs4751885 chr10:124020305 G/T cg09507567 chr10:124027408 NA 0.56 9.88 0.48 2.26e-20 Total body bone mineral density; LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.59 -0.43 3.41e-16 Bipolar disorder; LUSC cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg04990556 chr1:26633338 UBXN11 -0.46 -6.26 -0.32 1.18e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs2274273 0.905 rs8007944 chr14:55576816 A/C cg04306507 chr14:55594613 LGALS3 0.55 12.56 0.57 6.75e-30 Protein biomarker; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09475815 chr1:246670754 SMYD3 -0.43 -6.34 -0.33 7.27e-10 Electrocardiographic conduction measures; LUSC cis rs559928 0.597 rs2096706 chr11:63924446 T/G cg24687543 chr11:63912206 MACROD1 0.48 5.84 0.3 1.26e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs3820928 0.874 rs4675133 chr2:227843010 A/G cg11843606 chr2:227700838 RHBDD1 0.5 7.24 0.37 3.04e-12 Pulmonary function; LUSC cis rs11122272 0.735 rs2749709 chr1:231530476 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.15 -0.49 2.75e-21 Hemoglobin concentration; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.07 0.55 4.22e-28 Prudent dietary pattern; LUSC cis rs6142102 0.961 rs2284386 chr20:32644396 G/A cg08999081 chr20:33150536 PIGU 0.36 6.22 0.32 1.49e-9 Skin pigmentation; LUSC cis rs9399401 0.710 rs7765770 chr6:142687305 C/T cg03128060 chr6:142623767 GPR126 0.62 10.11 0.48 3.99e-21 Chronic obstructive pulmonary disease; LUSC cis rs2282526 0.615 rs162377 chr21:44926001 A/G cg01579765 chr21:45077557 HSF2BP -0.46 -8.7 -0.43 1.57e-16 Mean corpuscular hemoglobin; LUSC cis rs9326248 0.559 rs482371 chr11:116752163 T/C cg11861562 chr11:117069780 TAGLN 0.34 6.58 0.34 1.84e-10 Blood protein levels; LUSC cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9790314 0.875 rs459515 chr3:161092351 T/C cg03342759 chr3:160939853 NMD3 -0.51 -8.47 -0.42 7.93e-16 Morning vs. evening chronotype; LUSC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg26879891 chr1:152191343 HRNR -0.38 -6.78 -0.35 5.36e-11 Inflammatory skin disease; LUSC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.19 0.59 2.8099999999999997e-32 Hip circumference adjusted for BMI; LUSC cis rs61990749 0.597 rs176971 chr14:78191599 T/G cg02301378 chr14:78227641 SNW1;C14orf178 0.61 6.46 0.33 3.59e-10 Fibroblast growth factor basic levels; LUSC cis rs7681440 0.647 rs4522832 chr4:90819391 A/C cg15133208 chr4:90757351 SNCA -0.35 -5.98 -0.31 5.81e-9 Dementia with Lewy bodies; LUSC cis rs11190604 1.000 rs2295776 chr10:102295629 G/T cg07080220 chr10:102295463 HIF1AN 0.69 9.38 0.46 1.06e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg17279839 chr7:150038598 RARRES2 0.49 7.49 0.38 6.24e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg21724239 chr8:58056113 NA 0.79 9.39 0.46 9.94e-19 Developmental language disorder (linguistic errors); LUSC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.74 0.39 1.19e-13 Intelligence (multi-trait analysis); LUSC cis rs3806843 1.000 rs9686540 chr5:140174622 G/A cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.43e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs1538970 0.962 rs9429160 chr1:45827968 G/T cg06784218 chr1:46089804 CCDC17 0.32 5.87 0.31 1.03e-8 Platelet count; LUSC cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg15485101 chr11:133734466 NA 0.38 7.4 0.38 1.11e-12 Childhood ear infection; LUSC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg02569458 chr12:86230093 RASSF9 0.48 7.72 0.39 1.41e-13 Major depressive disorder; LUSC cis rs734999 0.545 rs12749591 chr1:2563250 G/T cg18932078 chr1:2524107 MMEL1 -0.27 -6.05 -0.31 3.81e-9 Ulcerative colitis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg09085823 chr20:30795283 POFUT1;PLAGL2 -0.46 -6.04 -0.31 4.05e-9 Hepatitis; LUSC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg10523679 chr1:76189770 ACADM -0.84 -11.33 -0.53 2.04e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs17539620 0.624 rs111484697 chr6:154838903 A/G cg20019720 chr6:154832845 CNKSR3 0.63 8.53 0.42 5.29e-16 Lipoprotein (a) levels; LUSC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg02117656 chr17:79614917 TSPAN10 0.32 5.86 0.31 1.11e-8 Eye color traits; LUSC cis rs1215050 0.740 rs185468 chr4:98756242 C/T cg05340658 chr4:99064831 C4orf37 0.44 6.91 0.35 2.46e-11 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs9951602 0.512 rs1599635 chr18:76643819 G/A cg02800362 chr5:177631904 HNRNPAB 0.83 12.4 0.56 2.55e-29 Obesity-related traits; LUSC cis rs11785400 0.762 rs1137522 chr8:143739020 A/C cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg19628046 chr18:33552617 C18orf21 0.51 6.17 0.32 1.96e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs68170813 0.559 rs4730229 chr7:106925353 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.79 -0.47 4.7e-20 Coronary artery disease; LUSC cis rs6480314 0.831 rs7080267 chr10:69980750 T/C cg06988349 chr10:69991859 ATOH7 0.36 5.91 0.31 8.42e-9 Optic nerve measurement (disc area); LUSC cis rs17685 0.702 rs6960598 chr7:75772991 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.54 -8.23 -0.41 4.13e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg26513180 chr16:89883248 FANCA 0.78 6.39 0.33 5.68e-10 Skin colour saturation; LUSC cis rs826838 0.935 rs7301104 chr12:39182821 C/T cg13010199 chr12:38710504 ALG10B 0.7 11.97 0.55 1.04e-27 Heart rate; LUSC cis rs6964587 1.000 rs6465347 chr7:91693837 A/G cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC trans rs1945213 0.694 rs1384099 chr11:55866040 A/C cg03929089 chr4:120376271 NA 0.68 7.63 0.39 2.56e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg26116260 chr4:7069785 GRPEL1 1.17 17.89 0.7 1.16e-50 Monocyte percentage of white cells; LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.41 0.38 1.04e-12 Alzheimer's disease; LUSC cis rs11190604 1.000 rs10883496 chr10:102221931 T/C cg07080220 chr10:102295463 HIF1AN 0.65 8.72 0.43 1.34e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.71 0.3 2.54e-8 Menopause (age at onset); LUSC cis rs4129767 0.647 rs1976703 chr17:76401328 C/T cg20026190 chr17:76395443 PGS1 0.34 5.85 0.31 1.15e-8 HDL cholesterol; LUSC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg25036284 chr2:26402008 FAM59B -0.68 -9.47 -0.46 5.29e-19 Gut microbiome composition (summer); LUSC trans rs61931739 0.500 rs11053223 chr12:34481947 T/A cg13010199 chr12:38710504 ALG10B 0.68 10.74 0.51 2.68e-23 Morning vs. evening chronotype; LUSC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.41 -6.43 -0.33 4.36e-10 Mean platelet volume; LUSC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg19318889 chr4:1322082 MAEA 0.53 8.71 0.43 1.46e-16 Obesity-related traits; LUSC cis rs2637266 0.935 rs7918777 chr10:78394375 A/G cg18941641 chr10:78392320 NA 0.42 7.62 0.38 2.59e-13 Pulmonary function; LUSC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.47 0.42 7.78e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs61931739 0.534 rs11053047 chr12:34161084 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.91 0.55 1.64e-27 Morning vs. evening chronotype; LUSC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.88 15.29 0.64 2.21e-40 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1691799 0.899 rs4762091 chr12:66747863 A/G cg16791601 chr12:66731901 HELB -0.71 -12.52 -0.57 9.7e-30 White blood cell count (basophil); LUSC cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 11.88 0.55 2.17e-27 Colorectal cancer; LUSC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.26 -0.37 2.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC trans rs877282 0.520 rs12360072 chr10:813082 C/T cg22713356 chr15:30763199 NA 0.48 7.16 0.36 5.32e-12 Uric acid levels; LUSC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg05973401 chr12:123451056 ABCB9 -0.5 -6.81 -0.35 4.57e-11 Neutrophil percentage of white cells; LUSC cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg03146154 chr1:46216737 IPP 0.57 8.31 0.41 2.38e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs929354 0.772 rs3802123 chr7:156970641 G/A cg17757837 chr7:157058334 UBE3C 0.86 13.85 0.6 9e-35 Body mass index; LUSC cis rs7799006 0.657 rs10447540 chr7:2301484 A/G cg02951883 chr7:2050386 MAD1L1 -0.37 -6.08 -0.32 3.37e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8060686 0.545 rs12444188 chr16:68282077 G/A cg09835421 chr16:68378352 PRMT7 -0.67 -7.02 -0.36 1.28e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2806561 0.765 rs1738469 chr1:23511407 G/C cg12483005 chr1:23474871 LUZP1 0.43 6.78 0.35 5.31e-11 Height; LUSC trans rs3808502 0.527 rs2736389 chr8:11161310 C/A cg06636001 chr8:8085503 FLJ10661 0.47 6.81 0.35 4.63e-11 Neuroticism; LUSC cis rs10193935 0.901 rs3755304 chr2:42589921 A/G cg27598129 chr2:42591480 NA 0.6 8.36 0.42 1.67e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs1371867 0.846 rs2439458 chr8:101297984 T/C cg06002616 chr8:101225028 SPAG1 -0.41 -6.93 -0.35 2.21e-11 Atrioventricular conduction; LUSC cis rs4478858 0.735 rs6687819 chr1:31801112 G/A cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs6076065 0.723 rs1936013 chr20:23363989 A/G cg11657817 chr20:23433608 CST11 0.42 7.9 0.4 4.11e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs7944584 1.000 rs7944584 chr11:47336320 A/T cg20307385 chr11:47447363 PSMC3 0.71 9.98 0.48 1.06e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg12963246 chr6:28129442 ZNF389 0.41 5.69 0.3 2.84e-8 Parkinson's disease; LUSC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg19774624 chr17:42201019 HDAC5 -0.81 -13.61 -0.6 7.03e-34 Total body bone mineral density; LUSC cis rs1348850 0.567 rs880898 chr2:178532470 C/T cg22681709 chr2:178499509 PDE11A -0.55 -10.98 -0.52 3.63e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6062509 0.895 rs6062497 chr20:62336258 C/T cg21849932 chr20:62369462 LIME1 -0.42 -6.03 -0.31 4.4e-9 Prostate cancer; LUSC trans rs28647808 0.881 rs41297211 chr9:136260721 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC trans rs208520 1.000 rs72882100 chr6:66981495 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg11494091 chr17:61959527 GH2 0.7 14.86 0.63 1.09e-38 Prudent dietary pattern; LUSC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg20887711 chr4:1340912 KIAA1530 0.48 7.56 0.38 4.03e-13 Obesity-related traits; LUSC cis rs3126085 0.935 rs11204934 chr1:152176848 C/A cg03465714 chr1:152285911 FLG 0.41 5.66 0.3 3.22e-8 Atopic dermatitis; LUSC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg14019146 chr3:50243930 SLC38A3 -0.32 -7.1 -0.36 7.5e-12 Intelligence (multi-trait analysis); LUSC cis rs1801251 1.000 rs1801251 chr2:233633460 G/A cg25237894 chr2:233734115 C2orf82 0.35 6.59 0.34 1.69e-10 Coronary artery disease; LUSC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg18904891 chr8:8559673 CLDN23 0.4 5.8 0.3 1.55e-8 Neuroticism; LUSC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg06656553 chr16:89960601 TCF25 -0.63 -5.7 -0.3 2.68e-8 Skin colour saturation; LUSC cis rs4474465 0.688 rs7929656 chr11:78276416 T/C cg27205649 chr11:78285834 NARS2 0.55 6.75 0.35 6.54e-11 Alzheimer's disease (survival time); LUSC cis rs28785552 0.796 rs8112908 chr19:53248041 C/T cg22067481 chr19:53234126 ZNF611 -0.43 -5.82 -0.3 1.39e-8 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.23e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2562456 0.755 rs2562421 chr19:21631304 T/G cg00806126 chr19:22604979 ZNF98 0.37 5.85 0.3 1.19e-8 Pain; LUSC cis rs6690583 0.623 rs2083284 chr1:85440023 C/T cg22153463 chr1:85462885 MCOLN2 0.62 5.78 0.3 1.7e-8 Serum sulfate level; LUSC cis rs950027 0.572 rs12910764 chr15:45609360 T/C cg09092052 chr15:45571596 NA 0.47 6.62 0.34 1.4e-10 Response to fenofibrate (adiponectin levels); LUSC cis rs28735056 0.967 rs498541 chr18:77589655 G/A cg20368463 chr18:77673604 PQLC1 -0.54 -7.75 -0.39 1.15e-13 Schizophrenia; LUSC cis rs6546550 0.933 rs6546554 chr2:70135706 G/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs2295359 1.000 rs4655524 chr1:67629469 G/A cg03340356 chr1:67600835 NA 0.4 6.46 0.33 3.74e-10 Psoriasis; LUSC cis rs4730250 0.707 rs3729877 chr7:106787065 T/G cg02696742 chr7:106810147 HBP1 0.64 9.04 0.44 1.32e-17 Osteoarthritis; LUSC cis rs920590 0.758 rs17091534 chr8:19670651 C/T cg03894339 chr8:19674705 INTS10 0.53 7.28 0.37 2.4e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg06873352 chr17:61820015 STRADA 0.72 12.18 0.55 1.76e-28 Prudent dietary pattern; LUSC cis rs72772090 0.539 rs11750671 chr5:96188482 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.88 -0.35 2.88e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg17385448 chr1:15911702 AGMAT 0.37 6.23 0.32 1.41e-9 Systolic blood pressure; LUSC cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg05347473 chr6:146136440 FBXO30 0.54 9.12 0.45 7.22e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.623 rs7205935 chr16:68152157 A/G cg26727032 chr16:67993705 SLC12A4 -0.39 -6.01 -0.31 4.8e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.659 rs61291849 chr17:56909867 T/C cg25039879 chr17:56429692 SUPT4H1 0.67 8.95 0.44 2.48e-17 Cognitive test performance; LUSC cis rs9318086 0.648 rs78881146 chr13:24468704 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.45 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg02428538 chr16:24856791 SLC5A11 -0.56 -6.27 -0.32 1.12e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs3806843 0.551 rs246018 chr5:140335043 T/C cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs4660306 1.000 rs7536557 chr1:45992114 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.67 -0.34 1.03e-10 Homocysteine levels; LUSC cis rs9462027 0.628 rs7776219 chr6:34784667 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.74 -0.3 2.13e-8 Systemic lupus erythematosus; LUSC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.07 0.44 1.03e-17 Tonsillectomy; LUSC cis rs9807989 0.811 rs67088699 chr2:102968751 C/T cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC cis rs66731853 0.769 rs477679 chr1:20894618 A/G cg04087271 chr1:20915334 CDA 0.54 8.96 0.44 2.27e-17 Mean corpuscular volume; LUSC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg25767906 chr1:53392781 SCP2 0.39 6.68 0.34 9.86e-11 Monocyte count; LUSC cis rs4594175 0.677 rs7149846 chr14:51739654 A/C cg23942311 chr14:51606299 NA 0.31 6.08 0.32 3.28e-9 Cancer; LUSC trans rs853679 0.556 rs34706883 chr6:27805255 A/C cg01620082 chr3:125678407 NA -0.82 -7.24 -0.37 3.06e-12 Depression; LUSC trans rs6598955 0.671 rs7550997 chr1:26596080 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.71 -0.43 1.45e-16 Obesity-related traits; LUSC cis rs9650657 0.504 rs7813802 chr8:11033976 C/T cg21775007 chr8:11205619 TDH 0.54 7.6 0.38 3.06e-13 Neuroticism; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg18765753 chr7:1198926 ZFAND2A -0.54 -9.69 -0.47 9.97e-20 Longevity;Endometriosis; LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg18099408 chr3:52552593 STAB1 -0.42 -7.14 -0.36 6e-12 Bipolar disorder; LUSC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs713477 0.967 rs8020152 chr14:55907025 T/A cg13175173 chr14:55914753 NA -0.32 -6.67 -0.34 1.07e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs6542838 0.641 rs11123756 chr2:99508012 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.47 6.1 0.32 2.99e-9 Fear of minor pain; LUSC cis rs601339 1.000 rs507525 chr12:123181581 T/C cg11919336 chr12:123188078 GPR109A 0.41 6.03 0.31 4.25e-9 Adiponectin levels; LUSC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg02269571 chr22:50332266 NA -0.57 -8.54 -0.42 4.87e-16 Schizophrenia; LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg26314531 chr2:26401878 FAM59B 0.74 8.8 0.43 7.3e-17 Gut microbiome composition (summer); LUSC cis rs7582180 0.739 rs11687352 chr2:100919888 A/C cg08017756 chr2:100939284 LONRF2 -0.44 -8.33 -0.41 2.09e-15 Intelligence (multi-trait analysis); LUSC trans rs7829975 0.714 rs60315134 chr8:8670599 A/G cg27411982 chr8:10470053 RP1L1 0.42 6.59 0.34 1.71e-10 Mood instability; LUSC cis rs9560113 0.960 rs950891 chr13:112173992 G/A cg14154082 chr13:112174009 NA -0.36 -7.77 -0.39 9.73e-14 Menarche (age at onset); LUSC cis rs10746514 1.000 rs10746514 chr1:232246027 G/A cg09506761 chr1:232265262 NA 0.47 7.64 0.39 2.37e-13 Response to statin therapy; LUSC cis rs2230307 0.536 rs561119 chr1:100603891 G/A cg24955406 chr1:100503596 HIAT1 -0.64 -6.9 -0.35 2.63e-11 Carotid intima media thickness; LUSC cis rs11098499 0.909 rs28581362 chr4:120283548 T/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC trans rs1997103 1.000 rs4947504 chr7:55409428 T/C cg20935933 chr6:143382018 AIG1 0.5 7.36 0.37 1.45e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg08847533 chr14:75593920 NEK9 -0.85 -15.37 -0.64 1.08e-40 Height; LUSC cis rs6546886 0.957 rs12713806 chr2:74258136 T/G cg14702570 chr2:74259524 NA -0.31 -5.96 -0.31 6.42e-9 Dialysis-related mortality; LUSC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg00339695 chr16:24857497 SLC5A11 0.38 6.64 0.34 1.27e-10 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg02711726 chr17:80685570 FN3KRP -0.42 -6.56 -0.34 2.1e-10 Glycated hemoglobin levels; LUSC trans rs208515 0.525 rs1351866 chr6:66696969 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 14.41 0.62 5.8e-37 Exhaled nitric oxide levels; LUSC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg05754148 chr16:3507555 NAT15 0.58 8.55 0.42 4.5e-16 Tuberculosis; LUSC cis rs10876993 0.890 rs774888 chr12:58036506 A/G cg18357645 chr12:58087776 OS9 0.49 7.3 0.37 2.17e-12 Celiac disease or Rheumatoid arthritis; LUSC cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg12011299 chr4:100065546 ADH4 0.64 10.09 0.48 4.42e-21 Alcohol dependence; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00177390 chr1:185126125 C1orf25;C1orf26 -0.43 -6.3 -0.33 9.25e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9815354 0.857 rs73073252 chr3:42016891 C/T cg03022575 chr3:42003672 ULK4 0.56 5.92 0.31 7.96e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs12618769 0.597 rs7585939 chr2:99219206 T/A cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs73206853 0.764 rs17682012 chr12:111094454 A/G cg12870014 chr12:110450643 ANKRD13A -0.73 -7.27 -0.37 2.52e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1559088 0.901 rs12610053 chr19:33582606 A/G cg27124370 chr19:33622961 WDR88 0.57 7.42 0.38 1.01e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC trans rs1908814 0.516 rs7812563 chr8:11794488 T/G cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.7e-9 Neuroticism; LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg00149659 chr3:10157352 C3orf10 -0.93 -13.58 -0.6 9.68e-34 Alzheimer's disease; LUSC cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg07741184 chr6:167504864 NA 0.33 5.96 0.31 6.54e-9 Crohn's disease; LUSC cis rs17270561 0.666 rs1141034 chr6:25780332 C/T cg16482183 chr6:26056742 HIST1H1C 0.58 8.0 0.4 2.04e-14 Iron status biomarkers; LUSC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg00599273 chr12:58146742 CDK4 0.31 5.96 0.31 6.5e-9 Multiple sclerosis; LUSC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg01879757 chr17:41196368 BRCA1 -0.5 -8.0 -0.4 2.03e-14 Menopause (age at onset); LUSC cis rs9361491 0.508 rs9352611 chr6:79396968 T/C cg05283184 chr6:79620031 NA -0.39 -6.93 -0.35 2.16e-11 Intelligence (multi-trait analysis); LUSC cis rs2835872 0.584 rs1709816 chr21:39077259 A/C cg20424643 chr21:39039972 KCNJ6 -0.42 -6.57 -0.34 1.97e-10 Electroencephalographic traits in alcoholism; LUSC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg05855489 chr10:104503620 C10orf26 0.57 9.18 0.45 4.79e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6121246 0.697 rs6088864 chr20:30228157 G/A cg18721089 chr20:30220636 NA -0.41 -6.78 -0.35 5.38e-11 Mean corpuscular hemoglobin; LUSC cis rs62400317 0.859 rs11964844 chr6:45258823 T/A cg20913747 chr6:44695427 NA -0.45 -7.42 -0.38 9.65e-13 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23889236 chr11:706100 EPS8L2 -0.39 -6.02 -0.31 4.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11971779 0.680 rs6467837 chr7:139023575 A/G cg07862535 chr7:139043722 LUC7L2 0.53 6.6 0.34 1.66e-10 Diisocyanate-induced asthma; LUSC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.42 5.87 0.31 1.05e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs7712401 0.715 rs13164161 chr5:122346897 G/A cg19077854 chr5:122220652 SNX24 -0.41 -8.85 -0.44 5.29e-17 Mean platelet volume; LUSC cis rs5758511 0.680 rs5758684 chr22:42649509 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.82 -0.3 1.39e-8 Birth weight; LUSC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg02038168 chr22:39784481 NA -0.48 -8.01 -0.4 1.92e-14 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg21573476 chr21:45109991 RRP1B -0.38 -6.19 -0.32 1.72e-9 Mean corpuscular volume; LUSC trans rs6030 1.000 rs10800454 chr1:169509163 A/G cg16792071 chr10:134842795 NA 0.28 6.18 0.32 1.83e-9 Uric acid levels; LUSC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg23711669 chr6:146136114 FBXO30 0.9 17.11 0.68 1.48e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs394563 0.591 rs6570963 chr6:149691355 T/G cg03678062 chr6:149772716 ZC3H12D 0.31 6.33 0.33 8.1e-10 Dupuytren's disease; LUSC cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.45 0.53 7.91e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs634534 0.561 rs14157 chr11:65769780 T/G cg17712092 chr4:129076599 LARP1B 0.69 10.37 0.49 5.1e-22 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs7607369 0.648 rs7599984 chr2:219656713 T/G cg02176678 chr2:219576539 TTLL4 -0.66 -12.89 -0.58 4.08e-31 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs12980942 0.872 rs10421990 chr19:41797099 C/T cg25627403 chr19:41769009 HNRNPUL1 0.58 6.31 0.33 8.86e-10 Coronary artery disease; LUSC cis rs2273669 0.588 rs79465564 chr6:109350290 C/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 9.1e-9 Prostate cancer; LUSC cis rs477692 0.673 rs556253 chr10:131355781 G/A cg26102564 chr10:131424627 MGMT 0.39 6.04 0.31 4.07e-9 Response to temozolomide; LUSC cis rs2290416 0.892 rs34178175 chr8:144664687 G/A cg26536354 chr8:144654954 C8orf73 0.58 6.79 0.35 5.15e-11 Attention deficit hyperactivity disorder; LUSC cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2652834 0.851 rs16946416 chr15:63356721 A/T cg05507819 chr15:63340323 TPM1 -0.69 -8.66 -0.43 2.05e-16 HDL cholesterol; LUSC trans rs12682352 0.602 rs1473029 chr8:8668917 A/C cg21775007 chr8:11205619 TDH 0.44 6.08 0.32 3.37e-9 Neuroticism; LUSC cis rs9905704 0.624 rs34718875 chr17:57072461 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -7.44 -0.38 8.48e-13 Testicular germ cell tumor; LUSC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg13175981 chr1:150552382 MCL1 0.52 7.37 0.37 1.37e-12 Tonsillectomy; LUSC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg16586182 chr3:47516702 SCAP -0.52 -8.03 -0.4 1.65e-14 Colorectal cancer; LUSC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg00343986 chr7:65444356 GUSB -0.41 -6.07 -0.32 3.52e-9 Aortic root size; LUSC cis rs17621444 0.522 rs10886580 chr10:121803633 A/G cg02041677 chr10:121771263 NA 0.32 6.14 0.32 2.4e-9 IgG glycosylation; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg11905131 chr22:24372483 LOC391322 -0.54 -8.9 -0.44 3.64e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg05738196 chr6:26577821 NA -0.59 -6.93 -0.35 2.12e-11 Intelligence (multi-trait analysis); LUSC trans rs11764590 0.543 rs55893771 chr7:2096255 C/T cg25206134 chr2:45395956 NA 0.59 6.38 0.33 5.8e-10 Neuroticism; LUSC cis rs7766436 0.885 rs765782 chr6:22592216 A/G cg13666174 chr6:22585274 NA -0.43 -6.31 -0.33 8.81e-10 Coronary artery disease; LUSC trans rs61931739 0.500 rs6488218 chr12:34452587 T/C cg13010199 chr12:38710504 ALG10B 0.59 9.34 0.46 1.38e-18 Morning vs. evening chronotype; LUSC cis rs12681287 0.547 rs9942823 chr8:87509177 A/G cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs7712401 0.601 rs246303 chr5:122251717 C/G cg19077854 chr5:122220652 SNX24 0.41 8.97 0.44 2.22e-17 Mean platelet volume; LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -10.95 -0.51 4.68e-24 Bipolar disorder and schizophrenia; LUSC cis rs965469 1.000 rs6037560 chr20:3323055 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -5.7 -0.3 2.57e-8 IFN-related cytopenia; LUSC cis rs7829975 0.509 rs2945269 chr8:8115578 G/C cg14343924 chr8:8086146 FLJ10661 0.42 5.75 0.3 1.97e-8 Mood instability; LUSC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg24829409 chr8:58192753 C8orf71 0.55 5.84 0.3 1.26e-8 Developmental language disorder (linguistic errors); LUSC cis rs77633900 0.614 rs2469241 chr15:76873908 A/G cg21673338 chr15:77095150 SCAPER -0.65 -6.68 -0.34 1.02e-10 Non-glioblastoma glioma;Glioma; LUSC cis rs791888 0.929 rs2755431 chr10:89415104 C/T cg13926569 chr10:89418898 PAPSS2 -0.34 -6.52 -0.34 2.57e-10 Magnesium levels; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg22963979 chr7:1858916 MAD1L1 -0.7 -11.81 -0.54 4.04e-27 Bipolar disorder and schizophrenia; LUSC cis rs7264396 0.616 rs6142476 chr20:34581216 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.1 -0.36 7.45e-12 Total cholesterol levels; LUSC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.87e-11 Cystic fibrosis severity; LUSC cis rs10779751 1.000 rs4845987 chr1:11306279 G/C cg08854313 chr1:11322531 MTOR 0.92 16.17 0.66 7.91e-44 Body mass index; LUSC cis rs6424115 0.830 rs6680132 chr1:24198804 T/C cg15997130 chr1:24165203 NA 0.52 8.62 0.43 2.63e-16 Immature fraction of reticulocytes; LUSC cis rs4242434 0.927 rs2291234 chr8:22464390 T/C cg03733263 chr8:22462867 KIAA1967 0.99 18.35 0.71 1.7e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs17661538 0.504 rs34537345 chr10:18458587 A/G cg03634479 chr10:18430412 CACNB2 0.63 5.92 0.31 8.07e-9 Response to antipsychotic treatment; LUSC cis rs1692580 0.870 rs263532 chr1:2164116 T/C cg04315214 chr1:2043799 PRKCZ -0.3 -5.75 -0.3 1.98e-8 Coronary artery disease; LUSC cis rs7312933 0.558 rs4768411 chr12:42855390 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.46 -6.59 -0.34 1.66e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg23505145 chr19:12996616 KLF1 0.64 10.74 0.51 2.69e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs7937682 1.000 rs11213973 chr11:111538903 A/T cg09085632 chr11:111637200 PPP2R1B -1.1 -17.42 -0.69 8.65e-49 Primary sclerosing cholangitis; LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08432527 chr16:48278242 LONP2 0.76 6.09 0.32 3.17e-9 Cognitive performance; LUSC cis rs9462027 0.606 rs205258 chr6:34564243 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.17 -0.32 1.94e-9 Systemic lupus erythematosus; LUSC cis rs8179 1.000 rs42033 chr7:92237533 A/T cg15732164 chr7:92237376 CDK6 -0.54 -7.2 -0.37 4.02e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg02569458 chr12:86230093 RASSF9 -0.47 -7.95 -0.4 2.95e-14 Major depressive disorder; LUSC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg25838465 chr1:92012736 NA -0.77 -16.45 -0.67 5.71e-45 Breast cancer; LUSC trans rs61931739 0.500 rs11053236 chr12:34507962 C/G cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.25e-22 Morning vs. evening chronotype; LUSC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg08392591 chr16:89556376 ANKRD11 -0.4 -6.02 -0.31 4.68e-9 Multiple myeloma (IgH translocation); LUSC cis rs6736093 0.763 rs4848973 chr2:112790562 G/A cg12686935 chr2:112915763 FBLN7 -0.39 -6.22 -0.32 1.45e-9 Coronary artery disease; LUSC cis rs4494114 0.967 rs3814342 chr1:39325983 A/G cg25970120 chr1:39325951 RRAGC -0.42 -6.46 -0.33 3.77e-10 Blood protein levels; LUSC cis rs929354 0.742 rs10251112 chr7:156963524 A/G cg05182265 chr7:156933206 UBE3C -0.6 -9.73 -0.47 7.32e-20 Body mass index; LUSC cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg04850211 chr1:228464232 OBSCN 0.31 5.68 0.3 2.95e-8 Diastolic blood pressure; LUSC cis rs4243830 0.850 rs13513 chr1:6585804 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.66 -0.47 1.24e-19 Body mass index; LUSC cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg24642439 chr20:33292090 TP53INP2 0.55 8.59 0.43 3.3e-16 Coronary artery disease; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg10150615 chr22:24372951 LOC391322 -0.42 -6.82 -0.35 4.24e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14442939 chr10:27389572 ANKRD26 0.84 9.84 0.47 3.2e-20 Breast cancer; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg25729922 chr1:20834612 MUL1 0.67 5.96 0.31 6.32e-9 Body mass index; LUSC cis rs4839421 0.646 rs4839026 chr1:111018505 A/G cg06880108 chr1:111021908 CYMP 0.35 5.74 0.3 2.16e-8 Response to bupropion in depression; LUSC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg09455208 chr3:40491958 NA 0.57 10.09 0.48 4.35e-21 Renal cell carcinoma; LUSC cis rs1371867 0.875 rs1788174 chr8:101330957 C/G cg06636551 chr8:101224915 SPAG1 0.42 7.53 0.38 4.78e-13 Atrioventricular conduction; LUSC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.95 -0.48 1.35e-20 Glomerular filtration rate (creatinine); LUSC cis rs9399401 0.601 rs262120 chr6:142842360 C/A cg03128060 chr6:142623767 GPR126 0.5 8.29 0.41 2.82e-15 Chronic obstructive pulmonary disease; LUSC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg14893161 chr1:205819251 PM20D1 0.45 6.41 0.33 4.84e-10 Parkinson's disease; LUSC trans rs7824557 0.734 rs2293856 chr8:11177447 C/T cg06636001 chr8:8085503 FLJ10661 0.56 8.44 0.42 9.62e-16 Retinal vascular caliber; LUSC trans rs8072100 0.817 rs7213086 chr17:45752310 C/G cg04995722 chr7:26192034 NFE2L3 -0.39 -6.28 -0.32 1.06e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg09904177 chr6:26538194 HMGN4 0.43 6.29 0.33 1.02e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7674212 0.556 rs223401 chr4:103738972 T/C cg16532752 chr4:104119610 CENPE -0.42 -5.96 -0.31 6.27e-9 Type 2 diabetes; LUSC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.78 8.11 0.41 9.99e-15 Initial pursuit acceleration; LUSC cis rs6665290 0.669 rs6426558 chr1:227175367 G/T cg10327440 chr1:227177885 CDC42BPA -1.11 -28.41 -0.84 3.92e-91 Myeloid white cell count; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg00945038 chr17:61921165 SMARCD2 0.53 9.39 0.46 9.85e-19 Prudent dietary pattern; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.73 -0.47 7.5e-20 Bipolar disorder; LUSC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.83 -0.81 7.74e-78 Height; LUSC cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg01065977 chr19:18549689 ISYNA1 -0.23 -6.06 -0.31 3.73e-9 Breast cancer; LUSC cis rs454953 0.533 rs211436 chr6:133612992 A/G cg07327468 chr6:133561765 EYA4 -0.41 -5.98 -0.31 5.79e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs1003719 0.788 rs4817849 chr21:38469796 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg23758822 chr17:41437982 NA -0.98 -18.94 -0.72 7.15e-55 Menopause (age at onset); LUSC cis rs478304 0.651 rs11227299 chr11:65549570 C/G cg05805236 chr11:65401703 PCNXL3 -0.55 -8.9 -0.44 3.6e-17 Acne (severe); LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19717773 chr7:2847554 GNA12 -0.38 -6.2 -0.32 1.67e-9 Height; LUSC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg16049864 chr8:95962084 TP53INP1 0.41 6.75 0.35 6.4e-11 Type 2 diabetes; LUSC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg16386425 chr10:429943 DIP2C -0.45 -7.19 -0.37 4.24e-12 Psychosis in Alzheimer's disease; LUSC cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.99 0.36 1.52e-11 Rheumatoid arthritis; LUSC trans rs7824557 0.767 rs11775635 chr8:11164865 G/A cg15556689 chr8:8085844 FLJ10661 0.56 8.64 0.43 2.4e-16 Retinal vascular caliber; LUSC cis rs1983170 0.799 rs2063055 chr1:92020835 G/T cg25838465 chr1:92012736 NA 0.43 5.92 0.31 7.8e-9 Eosinophil percentage of white cells; LUSC cis rs2413583 0.591 rs115371106 chr22:39726809 G/A cg17798944 chr22:39715225 SNORD43;RPL3 0.64 5.77 0.3 1.79e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs752010 0.523 rs10890160 chr1:42120011 A/G cg06885757 chr1:42089581 HIVEP3 0.46 9.89 0.48 2.12e-20 Lupus nephritis in systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14943953 chr10:64564468 ADO -0.44 -6.6 -0.34 1.6e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg20887711 chr4:1340912 KIAA1530 0.48 7.51 0.38 5.43e-13 Longevity; LUSC cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg18200150 chr17:30822561 MYO1D -0.36 -6.85 -0.35 3.53e-11 Schizophrenia; LUSC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg06221963 chr1:154839813 KCNN3 -0.61 -13.72 -0.6 2.81e-34 Prostate cancer; LUSC cis rs7605827 0.930 rs1852751 chr2:15557320 C/T cg19274914 chr2:15703543 NA 0.46 8.88 0.44 4.23e-17 Educational attainment (years of education); LUSC cis rs12519773 0.549 rs11738974 chr5:92537336 G/A cg18783429 chr5:92414398 NA 0.33 6.91 0.35 2.53e-11 Migraine; LUSC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg21665744 chr7:39171113 POU6F2 0.47 7.56 0.38 4e-13 IgG glycosylation; LUSC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg07701084 chr6:150067640 NUP43 0.51 7.64 0.39 2.37e-13 Lung cancer; LUSC cis rs2274273 0.600 rs10134317 chr14:55793448 C/T cg04306507 chr14:55594613 LGALS3 0.47 9.23 0.45 3.27e-18 Protein biomarker; LUSC cis rs7043114 0.525 rs10761153 chr9:95130769 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.58 -0.34 1.85e-10 Height; LUSC trans rs61931739 0.635 rs1525895 chr12:33966496 A/G cg26384229 chr12:38710491 ALG10B 0.49 7.48 0.38 6.72e-13 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg15145296 chr3:125709740 NA -0.58 -6.44 -0.33 4.06e-10 Blood pressure (smoking interaction); LUSC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 8.73 0.43 1.22e-16 Height; LUSC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg16339924 chr4:17578868 LAP3 0.54 8.12 0.41 9.14e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs478304 0.934 rs603645 chr11:65533000 A/C cg08755490 chr11:65554678 OVOL1 0.41 5.87 0.31 1.05e-8 Acne (severe); LUSC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1499972 0.941 rs62264774 chr3:117647906 C/G cg07612923 chr3:117604196 NA 0.65 5.87 0.31 1.03e-8 Schizophrenia; LUSC cis rs921968 0.565 rs3755045 chr2:219609162 T/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.17 -0.49 2.38e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs4363385 0.747 rs4314835 chr1:152984901 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.88 -0.31 9.76e-9 Inflammatory skin disease; LUSC cis rs7666738 0.519 rs11732209 chr4:98801643 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.0 0.44 1.76e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs2018683 1.000 rs2018683 chr7:29014195 G/T cg19402173 chr7:128379420 CALU -0.56 -9.69 -0.47 9.76e-20 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg22496339 chr2:162101262 NA 0.52 7.52 0.38 5.26e-13 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2749705 chr1:231526696 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.7 -0.47 9.19e-20 Hemoglobin concentration; LUSC cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg08999081 chr20:33150536 PIGU 0.43 7.86 0.4 5.2e-14 Coronary artery disease; LUSC trans rs61931739 0.500 rs7965421 chr12:34523624 G/T cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg00933542 chr6:150070202 PCMT1 0.33 6.78 0.35 5.49e-11 Lung cancer; LUSC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg10523679 chr1:76189770 ACADM 0.88 15.5 0.65 3.43e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.12 0.48 3.65e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs10751667 0.961 rs6597953 chr11:991099 G/A cg06064525 chr11:970664 AP2A2 -0.36 -7.06 -0.36 9.65e-12 Alzheimer's disease (late onset); LUSC cis rs6977660 0.941 rs10273208 chr7:19816371 T/C cg07541023 chr7:19748670 TWISTNB 0.56 6.38 0.33 5.97e-10 Thyroid stimulating hormone; LUSC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg05347473 chr6:146136440 FBXO30 0.58 10.1 0.48 4.16e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs10464366 0.746 rs4723822 chr7:39141613 C/T cg20302533 chr7:39170763 POU6F2 0.51 7.94 0.4 3.08e-14 IgG glycosylation; LUSC cis rs12519773 1.000 rs7711868 chr5:92461247 T/A cg18783429 chr5:92414398 NA 0.29 6.48 0.33 3.2e-10 Migraine; LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg21724239 chr8:58056113 NA 0.78 9.42 0.46 7.46e-19 Developmental language disorder (linguistic errors); LUSC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg09238746 chr17:78121135 EIF4A3 -0.6 -8.96 -0.44 2.34e-17 Yeast infection; LUSC cis rs722599 0.748 rs2537824 chr14:75367349 T/C cg06637938 chr14:75390232 RPS6KL1 -0.41 -5.98 -0.31 5.63e-9 IgG glycosylation; LUSC cis rs7851660 0.967 rs7860598 chr9:100600702 G/A cg13688889 chr9:100608707 NA -0.61 -10.38 -0.49 4.54e-22 Strep throat; LUSC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -6.05 -0.31 3.88e-9 Life satisfaction; LUSC cis rs7223966 1.000 rs8080211 chr17:61729882 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.67 0.34 1.04e-10 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs9291683 0.588 rs13113730 chr4:10017628 C/T cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Bone mineral density; LUSC cis rs9469578 1.000 rs9469582 chr6:33715939 A/G cg18708504 chr6:33715942 IP6K3 0.7 8.84 0.44 5.53e-17 Phosphorus levels; LUSC cis rs6500395 1.000 rs11641458 chr16:48670845 C/T cg04672837 chr16:48644449 N4BP1 0.46 6.91 0.35 2.41e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11098499 1.000 rs10029750 chr4:120172543 A/G cg24375607 chr4:120327624 NA 0.74 11.31 0.53 2.41e-25 Corneal astigmatism; LUSC cis rs1577917 0.958 rs34765423 chr6:86484448 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.87 -0.44 4.36e-17 Response to antipsychotic treatment; LUSC cis rs453301 0.682 rs2929308 chr8:9084121 T/A cg06636001 chr8:8085503 FLJ10661 -0.56 -8.38 -0.42 1.52e-15 Joint mobility (Beighton score); LUSC cis rs921968 0.541 rs4674308 chr2:219310483 A/C cg02176678 chr2:219576539 TTLL4 0.71 13.42 0.59 3.9e-33 Mean corpuscular hemoglobin concentration; LUSC cis rs6712932 1.000 rs6734358 chr2:105843732 A/C cg26874229 chr2:105853672 NA -0.32 -5.68 -0.3 2.87e-8 Type 2 diabetes; LUSC trans rs12495832 0.822 rs4405877 chr3:147829462 A/C cg05062820 chr16:1098546 NA -0.41 -6.18 -0.32 1.86e-9 Chin dimples; LUSC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg02269571 chr22:50332266 NA -0.55 -8.22 -0.41 4.65e-15 Schizophrenia; LUSC cis rs981844 0.775 rs17371274 chr4:154738713 A/G cg14289246 chr4:154710475 SFRP2 0.46 6.22 0.32 1.5e-9 Response to statins (LDL cholesterol change); LUSC cis rs7089973 0.604 rs7903663 chr10:116609904 G/A cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.46e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg11494091 chr17:61959527 GH2 -0.71 -16.54 -0.67 2.7e-45 Prudent dietary pattern; LUSC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.75 -0.35 6.54e-11 Blood protein levels; LUSC cis rs11098499 0.604 rs10022185 chr4:120571765 C/G cg24375607 chr4:120327624 NA 0.71 10.36 0.49 5.29e-22 Corneal astigmatism; LUSC cis rs250677 0.522 rs7702695 chr5:148402550 T/A cg18129178 chr5:148520854 ABLIM3 -0.56 -8.14 -0.41 7.77e-15 Breast cancer; LUSC cis rs36096196 0.891 rs12081179 chr1:2251119 A/G cg06784691 chr1:2245988 NA -0.33 -6.04 -0.31 4.04e-9 Coronary artery disease; LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 13.1 0.58 6.35e-32 Platelet count; LUSC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg22467129 chr15:76604101 ETFA -0.46 -7.41 -0.38 1.01e-12 Blood metabolite levels; LUSC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg11752832 chr7:134001865 SLC35B4 0.56 8.8 0.43 7.24e-17 Mean platelet volume; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg10729496 chr3:10149963 C3orf24 0.57 7.54 0.38 4.62e-13 Alzheimer's disease; LUSC cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg24642439 chr20:33292090 TP53INP2 -0.52 -7.92 -0.4 3.6e-14 Glomerular filtration rate (creatinine); LUSC cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg07424592 chr7:64974309 NA 0.69 6.19 0.32 1.81e-9 Diabetic kidney disease; LUSC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg03676636 chr4:99064102 C4orf37 0.36 7.95 0.4 2.98e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg01341218 chr17:43662625 NA 1.0 14.83 0.63 1.43e-38 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg06640241 chr16:89574553 SPG7 0.7 11.41 0.53 1.11e-25 Multiple myeloma (IgH translocation); LUSC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg18306943 chr3:40428807 ENTPD3 0.39 5.99 0.31 5.41e-9 Renal cell carcinoma; LUSC cis rs427394 0.802 rs274698 chr5:6730957 T/G cg10857441 chr5:6722123 POLS -0.47 -9.23 -0.45 3.28e-18 Menopause (age at onset); LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg13453750 chr1:205783389 SLC41A1 -0.34 -6.67 -0.34 1.04e-10 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03562264 chr6:36646551 CDKN1A 0.43 6.58 0.34 1.77e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg25174290 chr11:3078921 CARS 0.61 9.79 0.47 4.75e-20 Longevity; LUSC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg23625390 chr15:77176239 SCAPER 0.46 7.11 0.36 6.91e-12 Blood metabolite levels; LUSC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.79e-8 Depression; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg01238044 chr22:24384105 GSTT1 0.52 7.7 0.39 1.5700000000000001e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7829975 0.714 rs6994038 chr8:8660538 C/A cg21775007 chr8:11205619 TDH 0.44 6.11 0.32 2.72e-9 Mood instability; LUSC cis rs11828289 0.660 rs76458473 chr11:23237355 T/G cg20040320 chr11:23191996 NA -0.63 -6.19 -0.32 1.79e-9 Cancer; LUSC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg17385448 chr1:15911702 AGMAT 0.35 5.97 0.31 6.18e-9 Systolic blood pressure; LUSC cis rs7833986 1.000 rs34480844 chr8:57092973 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.58 8.87 0.44 4.64e-17 Height; LUSC cis rs9479482 1.000 rs5006620 chr6:150336665 C/T cg07578070 chr6:150326732 RAET1K 0.39 5.96 0.31 6.59e-9 Alopecia areata; LUSC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.67 0.39 1.92e-13 Bipolar disorder; LUSC cis rs367615 0.537 rs10463600 chr5:108663636 G/A cg17395555 chr5:108820864 NA 0.55 9.62 0.47 1.72e-19 Colorectal cancer (SNP x SNP interaction); LUSC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg15664640 chr17:80829946 TBCD 0.66 11.64 0.54 1.63e-26 Breast cancer; LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg22166914 chr1:53195759 ZYG11B 0.49 7.61 0.38 2.77e-13 Monocyte count; LUSC cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg25208724 chr1:156163844 SLC25A44 1.09 26.49 0.82 4.57e-84 Testicular germ cell tumor; LUSC cis rs7123876 0.587 rs11600831 chr11:72360220 C/T cg04827223 chr11:72435913 ARAP1 -0.59 -6.69 -0.34 9.45e-11 Body mass index; LUSC cis rs8099014 0.954 rs28393850 chr18:56129141 T/C cg12907477 chr18:56117327 MIR122 0.43 6.69 0.34 9.48e-11 Platelet count; LUSC cis rs10746514 0.804 rs1854822 chr1:232262270 G/C cg09506761 chr1:232265262 NA -0.56 -9.58 -0.46 2.36e-19 Response to statin therapy; LUSC trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg08975724 chr8:8085496 FLJ10661 0.5 7.51 0.38 5.42e-13 Neuroticism; LUSC cis rs11122272 0.735 rs2808601 chr1:231536571 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.02 0.48 7.84e-21 Hemoglobin concentration; LUSC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.05 -0.36 1.02e-11 Colorectal cancer; LUSC cis rs17270561 0.609 rs4712957 chr6:25719814 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 7.84 0.39 6.1e-14 Iron status biomarkers; LUSC cis rs2635047 0.967 rs2247784 chr18:44746997 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 6.88 0.35 3.02e-11 Educational attainment; LUSC cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg08999081 chr20:33150536 PIGU 0.44 8.08 0.4 1.19e-14 Coronary artery disease; LUSC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg03806693 chr22:41940476 POLR3H -1.04 -14.71 -0.63 4.3e-38 Vitiligo; LUSC cis rs4919694 1.000 rs4917986 chr10:104630181 T/C cg04362960 chr10:104952993 NT5C2 1.14 12.68 0.57 2.42e-30 Arsenic metabolism; LUSC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.86 0.31 1.13e-8 Tonsillectomy; LUSC cis rs8062405 1.000 rs7498555 chr16:28893571 T/C cg05966235 chr16:28915196 ATP2A1 0.34 5.87 0.31 1.07e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs763121 1.000 rs138464 chr22:38906432 C/T cg06022373 chr22:39101656 GTPBP1 -0.76 -12.24 -0.56 1.08e-28 Menopause (age at onset); LUSC cis rs1775715 0.737 rs12256714 chr10:32216262 A/G cg04359828 chr10:32216031 ARHGAP12 -0.38 -6.55 -0.34 2.19e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6964587 1.000 rs35317449 chr7:91637010 G/A cg22117172 chr7:91764530 CYP51A1 0.31 5.7 0.3 2.7e-8 Breast cancer; LUSC cis rs6429082 0.967 rs704710 chr1:235621026 A/G cg26050004 chr1:235667680 B3GALNT2 0.43 6.1 0.32 2.92e-9 Adiposity; LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg14092988 chr3:52407081 DNAH1 0.32 6.24 0.32 1.3e-9 Bipolar disorder; LUSC cis rs7193541 0.510 rs79473128 chr16:74589192 G/A cg01733217 chr16:74700730 RFWD3 0.73 11.18 0.52 7.36e-25 Multiple myeloma; LUSC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg18512352 chr11:47633146 NA 0.46 9.23 0.45 3.18e-18 Subjective well-being; LUSC cis rs13315871 0.929 rs79813245 chr3:58318475 G/A cg20936604 chr3:58311152 NA -0.76 -6.95 -0.36 1.9e-11 Cholesterol, total; LUSC trans rs7824557 0.767 rs6991606 chr8:11176159 G/A cg08975724 chr8:8085496 FLJ10661 0.46 6.85 0.35 3.61e-11 Retinal vascular caliber; LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7647973 0.593 rs9870755 chr3:49809841 A/G cg03060546 chr3:49711283 APEH 0.57 7.02 0.36 1.22e-11 Menarche (age at onset); LUSC trans rs62103177 0.608 rs4442895 chr18:77826399 C/G cg14227996 chr4:17616232 MED28 -0.51 -6.17 -0.32 1.99e-9 Opioid sensitivity; LUSC cis rs12042938 0.507 rs1655301 chr1:231731730 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.71 -11.61 -0.54 2.08e-26 Neuranatomic and neurocognitive phenotypes; LUSC cis rs4561483 0.549 rs33657 chr16:11969724 G/C cg08843971 chr16:11963173 GSPT1 -0.45 -6.9 -0.35 2.68e-11 Testicular germ cell tumor; LUSC cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg11584989 chr19:19387371 SF4 -0.62 -7.26 -0.37 2.72e-12 Bipolar disorder; LUSC cis rs6714710 0.603 rs58546246 chr2:98521823 C/A cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.18e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg01475377 chr6:109611718 NA -0.37 -6.55 -0.34 2.13e-10 Reticulocyte fraction of red cells; LUSC cis rs10100465 0.805 rs10955823 chr8:118676625 A/G cg09430518 chr8:118662568 NA -0.3 -5.76 -0.3 1.95e-8 Leprosy; LUSC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg08754478 chr10:133766260 PPP2R2D -0.62 -8.04 -0.4 1.62e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs1982963 1.000 rs1982963 chr14:52509101 C/T cg10843707 chr14:52510701 NID2 -0.41 -7.26 -0.37 2.79e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6460942 0.818 rs116613169 chr7:12234669 T/C cg06484146 chr7:12443880 VWDE -0.58 -5.65 -0.3 3.39e-8 Coronary artery disease; LUSC cis rs11190604 1.000 rs7088827 chr10:102303865 C/G cg23241863 chr10:102295624 HIF1AN 0.48 5.72 0.3 2.38e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs68170813 0.605 rs10464620 chr7:107135653 A/G cg24556660 chr7:106842632 COG5;HBP1 0.44 5.88 0.31 9.9e-9 Coronary artery disease; LUSC trans rs2262909 0.962 rs436662 chr19:22232107 C/T cg17074339 chr11:11642133 GALNTL4 -0.46 -7.07 -0.36 9.1e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg04511125 chr2:88470314 THNSL2 0.67 6.33 0.33 7.76e-10 Plasma clusterin levels; LUSC cis rs9325144 0.647 rs35138700 chr12:38804474 C/T cg26384229 chr12:38710491 ALG10B -0.6 -9.25 -0.45 2.76e-18 Morning vs. evening chronotype; LUSC cis rs1160297 0.576 rs1451460 chr2:53088148 C/T cg07782112 chr2:53107842 NA 0.4 6.45 0.33 3.84e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg06008330 chr7:65541103 ASL -0.4 -6.22 -0.32 1.52e-9 Aortic root size; LUSC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg20503657 chr10:835505 NA 0.98 13.57 0.6 1.07e-33 Eosinophil percentage of granulocytes; LUSC cis rs6582630 0.516 rs8186746 chr12:38347638 G/T cg13010199 chr12:38710504 ALG10B -0.43 -6.44 -0.33 4.25e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs4654899 0.758 rs10218584 chr1:21474480 C/G cg01072550 chr1:21505969 NA 0.48 7.42 0.38 9.68e-13 Superior frontal gyrus grey matter volume; LUSC cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg03146154 chr1:46216737 IPP 0.55 8.31 0.41 2.44e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7927771 0.800 rs11039200 chr11:47379646 A/C cg05585544 chr11:47624801 NA -0.42 -7.03 -0.36 1.14e-11 Subjective well-being; LUSC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg09267113 chr7:98030324 BAIAP2L1 0.39 6.0 0.31 5.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11166629 1.000 rs11166629 chr8:135636964 C/T cg21672855 chr8:135614777 ZFAT 0.35 5.71 0.3 2.47e-8 Smoking quantity; LUSC cis rs7940866 0.903 rs7940465 chr11:130861339 C/T cg12179176 chr11:130786555 SNX19 0.61 9.47 0.46 5.37e-19 Schizophrenia; LUSC cis rs924607 1.000 rs4045344 chr5:595870 G/T cg09021430 chr5:549028 NA 0.44 7.8 0.39 8.2e-14 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs34779708 0.931 rs4934710 chr10:35350416 T/C cg04310649 chr10:35416472 CREM -0.4 -6.13 -0.32 2.5e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1008375 1.000 rs10939743 chr4:17662731 G/A cg15017067 chr4:17643749 FAM184B 0.35 5.7 0.3 2.69e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4843747 0.749 rs13333619 chr16:88072076 C/T cg26811252 chr16:29126840 RRN3P2 0.65 10.55 0.5 1.15e-22 Menopause (age at onset); LUSC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg18240062 chr17:79603768 NPLOC4 0.58 10.12 0.48 3.7e-21 Eye color traits; LUSC cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.909 rs9994810 chr4:120381590 A/G cg24375607 chr4:120327624 NA 0.77 11.46 0.53 7.47e-26 Corneal astigmatism; LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg26335602 chr6:28129616 ZNF389 0.46 6.17 0.32 1.97e-9 Parkinson's disease; LUSC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg21433313 chr16:3507492 NAT15 0.67 11.16 0.52 8.44e-25 Tuberculosis; LUSC trans rs1495965 0.524 rs7546245 chr1:67750474 C/T cg16262963 chr14:104851903 NA 0.24 6.03 0.31 4.3e-9 Behcet's disease; LUSC cis rs12908161 1.000 rs17601029 chr15:85347709 A/G cg12863693 chr15:85201151 NMB 0.39 8.09 0.4 1.14e-14 Schizophrenia; LUSC cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg15790184 chr11:494944 RNH1 0.42 6.4 0.33 5.37e-10 Systemic lupus erythematosus; LUSC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg12257692 chr3:49977190 RBM6 0.24 6.61 0.34 1.53e-10 Intelligence (multi-trait analysis); LUSC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg05855489 chr10:104503620 C10orf26 0.67 9.76 0.47 5.8e-20 Allergic disease (asthma, hay fever or eczema); LUSC trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs3733418 0.929 rs4691138 chr4:165908641 A/G cg08992305 chr4:165878219 TRIM61;C4orf39 -0.51 -5.92 -0.31 8.03e-9 Obesity-related traits; LUSC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.71 0.34 8.5e-11 Intelligence (multi-trait analysis); LUSC cis rs9818758 0.556 rs9880309 chr3:49304329 G/C cg00383909 chr3:49044727 WDR6 1.16 10.36 0.49 5.26e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg18350739 chr11:68623251 NA -0.38 -6.86 -0.35 3.35e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs524023 0.914 rs11606370 chr11:64378452 C/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.46 -0.5 2.47e-22 Urate levels in obese individuals; LUSC cis rs4964805 0.594 rs9132 chr12:104166243 C/T cg02344784 chr12:104178138 NT5DC3 0.38 6.05 0.31 3.94e-9 Attention deficit hyperactivity disorder; LUSC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg02569458 chr12:86230093 RASSF9 0.52 8.57 0.42 3.81e-16 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02591199 chr4:113066609 C4orf32 -0.39 -6.24 -0.32 1.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs61931739 0.500 rs3922568 chr12:34560107 A/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.47e-11 Morning vs. evening chronotype; LUSC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg03264133 chr6:25882463 NA -0.64 -10.78 -0.51 1.84e-23 Blood metabolite levels; LUSC trans rs7671266 0.611 rs10939833 chr4:10309537 A/G cg26043149 chr18:55253948 FECH -0.5 -6.14 -0.32 2.37e-9 Cardiovascular disease risk factors; LUSC cis rs2439831 0.681 rs478104 chr15:43594900 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.94 11.4 0.53 1.22e-25 Lung cancer in ever smokers; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg06789412 chr3:101405552 RPL24 0.33 6.35 0.33 6.99e-10 Tuberculosis; LUSC cis rs11112613 0.775 rs10507194 chr12:105959488 G/A cg03607813 chr12:105948248 NA 0.81 11.21 0.52 5.76e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs8177253 0.696 rs4459901 chr3:133465699 T/C cg11941060 chr3:133502564 NA -0.45 -6.5 -0.33 3e-10 Iron status biomarkers; LUSC trans rs7605827 0.675 rs2111449 chr2:15616215 C/T cg21544402 chr1:151129160 TNFAIP8L2 -0.41 -6.07 -0.32 3.52e-9 Educational attainment (years of education); LUSC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg19046167 chr17:80928561 B3GNTL1 -0.52 -6.44 -0.33 4.07e-10 Bone mineral accretion in asthma (oral corticosteroid dose interaction); LUSC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg11344533 chr11:111475393 SIK2 -0.49 -6.89 -0.35 2.86e-11 Primary sclerosing cholangitis; LUSC cis rs2280018 0.538 rs7404526 chr16:15129162 A/G cg27102117 chr16:15229624 NA 0.58 9.69 0.47 9.63e-20 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg23719950 chr11:63933701 MACROD1 -0.61 -7.99 -0.4 2.22e-14 Mean platelet volume; LUSC cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.13 -0.36 6.2e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg04539111 chr16:67997858 SLC12A4 -0.46 -6.29 -0.33 9.81e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs800082 0.675 rs2117004 chr3:144180576 G/A cg24215973 chr2:240111563 HDAC4 0.45 6.74 0.35 6.79e-11 Smoking behavior; LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg11494091 chr17:61959527 GH2 0.7 15.04 0.64 2.08e-39 Prudent dietary pattern; LUSC cis rs6456156 0.586 rs12213683 chr6:167460718 G/A cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs10504073 0.626 rs9298106 chr8:50007508 T/G cg00325661 chr8:49890786 NA 0.61 10.22 0.49 1.61e-21 Blood metabolite ratios; LUSC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -6.08 -0.32 3.35e-9 Subjective well-being; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11342277 chr1:116915598 ATP1A1 -0.49 -6.54 -0.34 2.26e-10 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.954 rs11098526 chr4:120390359 C/T cg25214090 chr10:38739885 LOC399744 0.57 8.39 0.42 1.44e-15 Corneal astigmatism; LUSC cis rs1003719 0.788 rs4817844 chr21:38447064 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.68 -11.19 -0.52 6.55e-25 Eye color traits; LUSC cis rs2011503 0.739 rs4808973 chr19:19725456 A/G cg11244672 chr19:19639970 YJEFN3 0.48 6.15 0.32 2.16e-9 Bipolar disorder; LUSC cis rs9462027 0.628 rs2744949 chr6:34633862 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.24e-9 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg03676636 chr4:99064102 C4orf37 0.33 6.79 0.35 5.21e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.6e-11 Schizophrenia; LUSC cis rs17270561 0.609 rs9379788 chr6:25742759 A/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.65 0.39 2.21e-13 Iron status biomarkers; LUSC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs7560272 0.538 rs12233115 chr2:73931891 G/A cg20560298 chr2:73613845 ALMS1 0.38 5.74 0.3 2.14e-8 Schizophrenia; LUSC cis rs977987 0.806 rs8057203 chr16:75404974 T/C cg03315344 chr16:75512273 CHST6 0.48 9.25 0.45 2.73e-18 Dupuytren's disease; LUSC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.659 rs62083362 chr17:56846464 A/G cg25039879 chr17:56429692 SUPT4H1 0.67 9.01 0.44 1.65e-17 Cognitive test performance; LUSC cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg03146154 chr1:46216737 IPP -0.51 -7.44 -0.38 8.45e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg02034447 chr16:89574710 SPG7 0.44 6.49 0.33 3.09e-10 Multiple myeloma (IgH translocation); LUSC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg19592336 chr6:28129416 ZNF389 0.46 5.92 0.31 8.12e-9 Depression; LUSC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg21435336 chr19:17392852 ANKLE1 -0.43 -5.87 -0.31 1.07e-8 Systemic lupus erythematosus; LUSC cis rs7224314 1.000 rs11079691 chr17:65362552 T/A cg01507342 chr17:65387096 PITPNC1 -0.4 -6.85 -0.35 3.55e-11 Diisocyanate-induced asthma; LUSC trans rs62103177 0.608 rs4442895 chr18:77826399 C/G cg05926928 chr17:57297772 GDPD1 -0.71 -8.41 -0.42 1.17e-15 Opioid sensitivity; LUSC trans rs62055045 0.528 rs9935288 chr16:71552741 T/C cg09088153 chr15:96890598 NA -0.42 -6.09 -0.32 3.13e-9 Schizophrenia; LUSC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg23093090 chr10:104574429 C10orf26 -0.38 -7.06 -0.36 9.93e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11971779 0.584 rs17613864 chr7:139095587 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg06547715 chr2:218990976 CXCR2 0.33 6.35 0.33 7e-10 Ulcerative colitis; LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg20607798 chr8:58055168 NA 0.54 6.22 0.32 1.5e-9 Developmental language disorder (linguistic errors); LUSC cis rs11997175 0.545 rs59563980 chr8:33665377 C/T ch.8.33884649F chr8:33765107 NA 0.51 7.44 0.38 8.81e-13 Body mass index; LUSC cis rs34172651 0.917 rs11640931 chr16:24797919 A/G cg06028605 chr16:24865363 SLC5A11 0.46 8.1 0.41 1.03e-14 Intelligence (multi-trait analysis); LUSC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg13393036 chr8:95962371 TP53INP1 0.31 6.09 0.32 3.06e-9 Type 2 diabetes; LUSC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.66 0.34 1.16e-10 Lung cancer; LUSC cis rs1595825 0.945 rs16826320 chr2:198845623 T/C cg10547527 chr2:198650123 BOLL -0.5 -5.85 -0.3 1.16e-8 Ulcerative colitis; LUSC cis rs7618501 1.000 rs6446295 chr3:49809063 G/T cg24110177 chr3:50126178 RBM5 -0.43 -6.84 -0.35 3.77e-11 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs12219158 chr10:102302923 T/C cg07080220 chr10:102295463 HIF1AN 0.7 9.3 0.45 1.88e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg06001716 chr17:41278141 BRCA1;NBR2 -0.41 -6.42 -0.33 4.57e-10 Menopause (age at onset); LUSC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg12963246 chr6:28129442 ZNF389 0.54 7.45 0.38 8.25e-13 Depression; LUSC cis rs2985684 0.894 rs2354439 chr14:50019417 G/C cg04989706 chr14:50066350 PPIL5 -0.47 -6.34 -0.33 7.28e-10 Carotid intima media thickness; LUSC cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg22117172 chr7:91764530 CYP51A1 0.32 5.79 0.3 1.58e-8 Breast cancer; LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg14092988 chr3:52407081 DNAH1 0.33 6.32 0.33 8.52e-10 Bipolar disorder; LUSC cis rs4834770 1.000 rs10034579 chr4:120244029 A/C cg24375607 chr4:120327624 NA 0.41 5.84 0.3 1.21e-8 Blood protein levels; LUSC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg24920358 chr1:40204285 PPIE 0.6 10.8 0.51 1.64e-23 Blood protein levels; LUSC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg20203395 chr5:56204925 C5orf35 -0.74 -10.28 -0.49 9.79e-22 Initial pursuit acceleration; LUSC cis rs6696846 0.765 rs61822619 chr1:205090885 C/G cg00857998 chr1:205179979 DSTYK 0.65 10.16 0.49 2.63e-21 Red blood cell count; LUSC cis rs11112613 0.775 rs7959699 chr12:105959848 C/A cg03607813 chr12:105948248 NA 0.83 11.96 0.55 1.1e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs72960926 0.744 rs6926606 chr6:75034904 T/C cg03266952 chr6:74778945 NA -0.6 -6.01 -0.31 4.84e-9 Metabolite levels (MHPG); LUSC cis rs9457247 0.967 rs428805 chr6:167403132 C/A cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs11958404 0.860 rs56090852 chr5:157431120 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs344364 0.629 rs9806826 chr16:1894912 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.43 -6.58 -0.34 1.87e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg16132339 chr22:24313637 DDTL;DDT 0.41 6.39 0.33 5.59e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1595825 0.891 rs73056840 chr2:198783466 C/A cg00982548 chr2:198649783 BOLL -0.56 -7.04 -0.36 1.12e-11 Ulcerative colitis; LUSC cis rs4423214 0.840 rs2017686 chr11:71187061 C/G cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.85 -13.69 -0.6 3.66e-34 Menarche (age at onset); LUSC trans rs7581030 0.517 rs7590738 chr2:71525698 G/A cg06465196 chr4:154387603 KIAA0922 0.43 6.1 0.32 2.92e-9 Testicular germ cell tumor; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg11494091 chr17:61959527 GH2 0.65 13.88 0.6 6.8000000000000005e-35 Prudent dietary pattern; LUSC cis rs11997175 0.520 rs4733449 chr8:33628652 G/T ch.8.33884649F chr8:33765107 NA 0.51 8.19 0.41 5.69e-15 Body mass index; LUSC cis rs10504073 0.647 rs341807 chr8:50032676 C/T cg00325661 chr8:49890786 NA 0.6 9.75 0.47 6.18e-20 Blood metabolite ratios; LUSC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -10.14 -0.49 3.08e-21 Glomerular filtration rate (creatinine); LUSC cis rs752010 0.841 rs6661784 chr1:42080312 A/T cg06885757 chr1:42089581 HIVEP3 0.43 8.7 0.43 1.53e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs6062509 0.630 rs6011058 chr20:62356627 C/T cg01176363 chr20:62369445 LIME1 -0.46 -6.83 -0.35 4.11e-11 Prostate cancer; LUSC cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg17366294 chr4:99064904 C4orf37 0.5 8.7 0.43 1.54e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg19592336 chr6:28129416 ZNF389 0.52 6.96 0.36 1.86e-11 Parkinson's disease; LUSC trans rs7937682 1.000 rs11608149 chr11:111535102 G/A cg18187862 chr3:45730750 SACM1L -0.51 -6.26 -0.32 1.21e-9 Primary sclerosing cholangitis; LUSC cis rs11105298 0.891 rs4842653 chr12:89834113 C/T cg00757033 chr12:89920650 WDR51B 0.59 10.15 0.49 2.74e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.74 10.65 0.5 5.23e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10883723 0.810 rs12162 chr10:104240498 A/G cg22532475 chr10:104410764 TRIM8 -0.35 -6.42 -0.33 4.7e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7267979 0.934 rs4815423 chr20:25387521 A/G cg03522245 chr20:25566470 NINL -0.35 -5.72 -0.3 2.34e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06170053 chr6:21596959 SOX4 0.8 6.25 0.32 1.23e-9 Cognitive performance; LUSC cis rs1572438 0.811 rs9379179 chr6:879853 A/C cg13447295 chr6:887704 NA 0.46 7.18 0.37 4.47e-12 Aging; LUSC cis rs4595586 0.545 rs6580893 chr12:39371885 G/T cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.52e-15 Obesity-related traits; LUSC cis rs12973672 0.812 rs35250673 chr19:35762548 G/A cg12095397 chr19:35769544 USF2 0.44 6.67 0.34 1.09e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7582180 0.676 rs4264577 chr2:100930662 T/C cg12002119 chr2:101014098 CHST10 0.36 5.93 0.31 7.6e-9 Intelligence (multi-trait analysis); LUSC cis rs11997175 0.646 rs6468195 chr8:33724817 A/G ch.8.33884649F chr8:33765107 NA 0.47 6.99 0.36 1.48e-11 Body mass index; LUSC cis rs8048589 0.515 rs4780412 chr16:12232409 A/G cg02910054 chr16:12241554 SNX29 0.48 6.63 0.34 1.37e-10 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs7188861 0.813 rs7189989 chr16:11442710 G/A cg00044050 chr16:11439710 C16orf75 -0.55 -6.22 -0.32 1.45e-9 HDL cholesterol; LUSC trans rs35110281 0.626 rs162367 chr21:44934857 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.57 0.42 3.98e-16 Mean corpuscular volume; LUSC cis rs61931739 0.534 rs11052983 chr12:34045787 C/A cg06521331 chr12:34319734 NA -0.51 -8.37 -0.42 1.55e-15 Morning vs. evening chronotype; LUSC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg00074818 chr8:8560427 CLDN23 0.57 9.71 0.47 8.22e-20 Obesity-related traits; LUSC trans rs561341 0.556 rs542244 chr17:30307242 T/C cg27661571 chr11:113659931 NA -0.66 -7.58 -0.38 3.54e-13 Hip circumference adjusted for BMI; LUSC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg21028142 chr17:79581711 NPLOC4 0.34 8.31 0.41 2.36e-15 Eye color traits; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg13860548 chr1:15853252 DNAJC16 0.47 6.05 0.31 3.8e-9 Response to Homoharringtonine (cytotoxicity); LUSC trans rs979233 0.502 rs3851450 chr5:42126067 C/T cg07010552 chr17:7358735 CHRNB1 -0.42 -6.08 -0.32 3.36e-9 Systemic lupus erythematosus; LUSC cis rs7829975 0.742 rs7832968 chr8:8652889 G/A cg14343924 chr8:8086146 FLJ10661 0.42 5.69 0.3 2.72e-8 Mood instability; LUSC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg04267008 chr7:1944627 MAD1L1 0.45 6.65 0.34 1.2e-10 Bipolar disorder and schizophrenia; LUSC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 12.92 0.58 3.03e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg26384229 chr12:38710491 ALG10B 0.87 14.03 0.61 1.77e-35 Bladder cancer; LUSC cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg24812749 chr6:127587940 RNF146 0.83 12.28 0.56 7.58e-29 Breast cancer; LUSC cis rs1048238 0.506 rs848195 chr1:16286522 A/G cg22431228 chr1:16359049 CLCNKA 0.4 8.31 0.41 2.49e-15 Systolic blood pressure; LUSC cis rs35146811 0.731 rs2257213 chr7:99810113 T/C cg13334819 chr7:99746414 C7orf59 0.49 6.44 0.33 4.16e-10 Coronary artery disease; LUSC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg06544989 chr22:39130855 UNC84B 0.37 6.28 0.32 1.08e-9 Menopause (age at onset); LUSC trans rs911555 0.539 rs4374097 chr14:104072766 A/C cg03785828 chr5:81573306 RPS23 -0.37 -5.98 -0.31 5.74e-9 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.659 rs35103007 chr17:56900738 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.57 0.6 1.03e-33 Cognitive test performance; LUSC trans rs61931739 0.500 rs7306334 chr12:34482900 A/G cg13010199 chr12:38710504 ALG10B -0.66 -10.42 -0.5 3.2800000000000002e-22 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.863 rs6853998 chr4:120475860 C/A cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC trans rs7819412 0.936 rs7814499 chr8:11040647 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.13 -0.41 8.5e-15 Triglycerides; LUSC cis rs2506889 0.553 rs7548453 chr1:10589836 A/G cg17425144 chr1:10567563 PEX14 0.63 13.24 0.59 1.92e-32 Breast cancer; LUSC cis rs6964587 1.000 rs7781066 chr7:91691946 G/T cg17063962 chr7:91808500 NA 0.58 9.24 0.45 2.94e-18 Breast cancer; LUSC cis rs67478160 0.619 rs12437066 chr14:104236844 A/C cg01849466 chr14:104193079 ZFYVE21 -0.61 -10.38 -0.49 4.57e-22 Schizophrenia; LUSC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg09904177 chr6:26538194 HMGN4 -0.53 -6.21 -0.32 1.57e-9 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03868159 chr6:42532252 UBR2 0.42 6.26 0.32 1.16e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg13685833 chr1:53393034 SCP2 0.41 6.17 0.32 1.97e-9 Monocyte count; LUSC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Vitiligo; LUSC cis rs9747201 0.962 rs35051180 chr17:80135046 G/A cg18209359 chr17:80159595 CCDC57 0.39 6.66 0.34 1.15e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs793571 0.500 rs2555356 chr15:59016431 T/G cg05156742 chr15:59063176 FAM63B 0.51 7.53 0.38 4.72e-13 Schizophrenia; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.66 0.76 1.38e-65 Prudent dietary pattern; LUSC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg01017244 chr2:74357527 NA 0.69 13.11 0.58 6.01e-32 Gestational age at birth (maternal effect); LUSC cis rs34779708 0.766 rs35308730 chr10:35549796 C/T cg03585969 chr10:35415529 CREM 0.52 7.09 0.36 8.09e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg23711669 chr6:146136114 FBXO30 0.88 16.41 0.67 8.41e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs17270561 0.609 rs9358879 chr6:25742918 C/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.73 0.39 1.29e-13 Iron status biomarkers; LUSC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg06238570 chr21:40685208 BRWD1 0.46 7.08 0.36 8.78e-12 Cognitive function; LUSC trans rs11992162 0.551 rs35010200 chr8:11785655 G/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.72 -0.35 7.85e-11 Monocyte count; LUSC cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC cis rs7917772 0.546 rs10883743 chr10:104338389 T/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1981331 1.000 rs1981331 chr21:47995443 A/C cg23283320 chr21:48055893 PRMT2 1.12 8.14 0.41 7.72e-15 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC trans rs1814175 0.817 rs28525029 chr11:50045815 A/G cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs6700896 0.932 rs6678033 chr1:66077624 G/A cg04111102 chr1:66153794 NA 0.31 6.94 0.35 2.07e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs2204008 0.805 rs2874289 chr12:38258420 G/A cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC cis rs79349575 0.756 rs2643361 chr17:46977462 T/G cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg06784218 chr1:46089804 CCDC17 0.34 5.67 0.3 3.15e-8 Platelet count; LUSC cis rs950169 0.580 rs36126054 chr15:85177723 T/G cg12863693 chr15:85201151 NMB 0.37 7.72 0.39 1.34e-13 Schizophrenia; LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg24060327 chr5:131705240 SLC22A5 -0.43 -6.86 -0.35 3.43e-11 Blood metabolite levels; LUSC cis rs7267979 0.932 rs424487 chr20:25468131 C/G cg08601574 chr20:25228251 PYGB 0.41 6.12 0.32 2.63e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.51 0.46 3.9e-19 Bipolar disorder; LUSC cis rs7674212 0.556 rs34475639 chr4:103954851 C/T cg16532752 chr4:104119610 CENPE -0.45 -6.08 -0.32 3.35e-9 Type 2 diabetes; LUSC cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC trans rs61931739 0.517 rs12367881 chr12:34175508 T/C cg26384229 chr12:38710491 ALG10B 0.74 11.93 0.55 1.42e-27 Morning vs. evening chronotype; LUSC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.21e-12 Schizophrenia; LUSC cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg15839431 chr19:19639596 YJEFN3 -0.59 -6.34 -0.33 7.38e-10 Bipolar disorder; LUSC cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg23788917 chr6:8435910 SLC35B3 0.51 7.58 0.38 3.38e-13 Motion sickness; LUSC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11031096 0.678 rs11031220 chr11:4197638 G/A cg18678763 chr11:4115507 RRM1 -0.4 -5.69 -0.3 2.75e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg09455208 chr3:40491958 NA 0.59 10.09 0.48 4.42e-21 Renal cell carcinoma; LUSC cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.61 9.08 0.44 9.68e-18 Menarche (age at onset); LUSC trans rs7939886 0.920 rs10792448 chr11:55804542 C/G cg15704280 chr7:45808275 SEPT13 0.8 6.88 0.35 3.04e-11 Myopia (pathological); LUSC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg15557168 chr22:42548783 NA -0.47 -7.54 -0.38 4.43e-13 Schizophrenia; LUSC cis rs10028773 0.700 rs7690338 chr4:120256468 C/G cg24375607 chr4:120327624 NA 0.77 12.51 0.56 1.08e-29 Educational attainment; LUSC cis rs243505 0.528 rs1558419 chr7:148480233 C/T cg09806900 chr7:148480153 CUL1 0.61 9.31 0.45 1.76e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg27432699 chr2:27873401 GPN1 -0.56 -8.24 -0.41 4.06e-15 Total body bone mineral density; LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs2073300 0.609 rs1076776 chr20:23427399 C/T cg09953122 chr20:23471693 CST8 0.63 5.76 0.3 1.91e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg10172584 chr19:19639581 YJEFN3 -0.47 -5.89 -0.31 9.64e-9 Bipolar disorder; LUSC cis rs1775715 0.870 rs1755072 chr10:32266642 A/G cg04359828 chr10:32216031 ARHGAP12 -0.39 -6.49 -0.33 3.14e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg23283495 chr1:209979779 IRF6 0.64 9.29 0.45 2.04e-18 Cleft lip with or without cleft palate; LUSC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg24578937 chr1:2090814 PRKCZ -0.44 -9.71 -0.47 8.31e-20 Height; LUSC trans rs3942852 0.955 rs1532754 chr11:48115279 A/T cg03929089 chr4:120376271 NA -0.55 -6.3 -0.33 9.37e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs2439831 0.867 rs7170489 chr15:43636651 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs951366 0.538 rs56276813 chr1:205730573 G/T cg14893161 chr1:205819251 PM20D1 -0.47 -6.36 -0.33 6.61e-10 Menarche (age at onset); LUSC cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg24130564 chr14:104152367 KLC1 -0.48 -7.01 -0.36 1.29e-11 Intelligence (multi-trait analysis); LUSC cis rs6542838 0.641 rs13005124 chr2:99527680 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.49 -6.72 -0.35 7.64e-11 Fear of minor pain; LUSC cis rs12738007 0.717 rs4654328 chr1:29230345 C/T cg01925633 chr1:29338769 EPB41 0.38 5.66 0.3 3.25e-8 Schizophrenia; LUSC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.52e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg10253484 chr15:75165896 SCAMP2 -0.42 -5.98 -0.31 5.8e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.4 5.71 0.3 2.45e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg08132940 chr7:1081526 C7orf50 -0.46 -5.93 -0.31 7.64e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4704187 0.663 rs6897274 chr5:74426103 T/A cg03227963 chr5:74354835 NA 0.32 6.77 0.35 5.68e-11 Response to amphetamines; LUSC cis rs950027 0.620 rs1145080 chr15:45681338 C/T cg26924012 chr15:45694286 SPATA5L1 0.78 12.41 0.56 2.5e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs6692729 0.966 rs6697001 chr1:227014835 C/T cg10327440 chr1:227177885 CDC42BPA 0.48 6.96 0.36 1.81e-11 Electrodermal activity; LUSC cis rs2439831 0.867 rs28729853 chr15:43673680 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.91 9.69 0.47 9.79e-20 Lung cancer in ever smokers; LUSC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg11062466 chr8:58055876 NA 0.5 6.57 0.34 1.89e-10 Developmental language disorder (linguistic errors); LUSC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg17178900 chr1:205818956 PM20D1 0.44 5.94 0.31 7.3e-9 Parkinson's disease; LUSC trans rs804280 0.543 rs13261205 chr8:11791216 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.15 0.41 7.55e-15 Myopia (pathological); LUSC cis rs62458065 0.513 rs7805536 chr7:32573570 T/C cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.94 -0.31 7.2e-9 Metabolite levels (HVA/MHPG ratio); LUSC trans rs3857536 0.776 rs1002764 chr6:66945760 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg14019146 chr3:50243930 SLC38A3 0.32 7.11 0.36 7e-12 Intelligence (multi-trait analysis); LUSC cis rs11031096 0.655 rs10835734 chr11:4211832 A/C cg18678763 chr11:4115507 RRM1 -0.41 -5.72 -0.3 2.32e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1003719 0.788 rs59637309 chr21:38475398 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.77 -13.83 -0.6 1.02e-34 Total body bone mineral density; LUSC cis rs7100689 0.646 rs10466235 chr10:82149655 C/T cg00277334 chr10:82204260 NA 0.43 6.11 0.32 2.82e-9 Post bronchodilator FEV1; LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg12119029 chr16:89752879 CDK10 0.29 5.67 0.3 3.11e-8 Vitiligo; LUSC trans rs7618501 0.602 rs2071206 chr3:50160109 G/A cg21659725 chr3:3221576 CRBN -0.62 -10.29 -0.49 9.7e-22 Intelligence (multi-trait analysis); LUSC cis rs3767633 0.528 rs4417044 chr1:161888955 T/C cg27519958 chr1:161735129 ATF6 -0.43 -7.09 -0.36 8.08e-12 IgG glycosylation; LUSC cis rs7180079 0.925 rs56101352 chr15:64534299 C/T cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.57 0.38 3.73e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs11608355 0.618 rs2075435 chr12:109796832 C/T cg19025524 chr12:109796872 NA -0.5 -9.16 -0.45 5.34e-18 Neuroticism; LUSC cis rs11711311 1.000 rs7645473 chr3:113516187 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.75 -0.3 1.97e-8 IgG glycosylation; LUSC cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.46 0.38 7.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9796 0.621 rs58109657 chr15:41471750 A/G cg18705301 chr15:41695430 NDUFAF1 0.48 8.54 0.42 4.83e-16 Menopause (age at onset); LUSC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg14552801 chr7:65878734 NA 0.37 5.65 0.3 3.47e-8 Aortic root size; LUSC cis rs6681460 0.549 rs6680968 chr1:67034661 C/T cg02459107 chr1:67143332 SGIP1 0.32 5.67 0.3 3.05e-8 Presence of antiphospholipid antibodies; LUSC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg21963583 chr11:68658836 MRPL21 0.54 8.18 0.41 5.88e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12291225 0.679 rs4756786 chr11:14285900 C/A cg19336497 chr11:14380999 RRAS2 -0.57 -11.79 -0.54 4.75e-27 Sense of smell; LUSC cis rs11785693 0.862 rs11784262 chr8:4996942 G/A cg26367366 chr8:4980734 NA 0.71 8.39 0.42 1.35e-15 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2898290 0.622 rs978803 chr8:11343475 C/T cg21775007 chr8:11205619 TDH 0.51 7.91 0.4 3.78e-14 Systolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14544983 chr19:47248940 FKRP;STRN4 -0.41 -6.2 -0.32 1.71e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12545109 0.800 rs1996105 chr8:57413123 A/G cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.11e-10 Obesity-related traits; LUSC cis rs80130819 0.688 rs10783233 chr12:48590899 C/G cg24011408 chr12:48396354 COL2A1 0.44 5.67 0.3 3.1e-8 Prostate cancer; LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg16405210 chr4:1374714 KIAA1530 -0.52 -7.98 -0.4 2.43e-14 Obesity-related traits; LUSC cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg22496339 chr2:162101262 NA -0.57 -7.41 -0.38 1.03e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); LUSC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg19346786 chr7:2764209 NA -0.44 -7.54 -0.38 4.55e-13 Height; LUSC cis rs10911251 0.527 rs1537520 chr1:183084229 C/T ch.1.3577855R chr1:183094577 LAMC1 0.73 10.91 0.51 6.83e-24 Colorectal cancer; LUSC cis rs72781680 0.716 rs72788284 chr2:24097539 A/G cg08917208 chr2:24149416 ATAD2B 0.59 6.81 0.35 4.57e-11 Lymphocyte counts; LUSC cis rs8072100 0.512 rs9674670 chr17:45386157 G/A cg08085267 chr17:45401833 C17orf57 -0.64 -10.75 -0.51 2.41e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2921036 0.545 rs4840975 chr8:8363258 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.19 -0.32 1.78e-9 Neuroticism; LUSC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg18404041 chr3:52824283 ITIH1 -0.58 -9.62 -0.47 1.75e-19 Schizophrenia; LUSC cis rs6940638 0.688 rs1028308 chr6:27129757 G/A cg12826209 chr6:26865740 GUSBL1 0.53 7.57 0.38 3.73e-13 Intelligence (multi-trait analysis); LUSC cis rs921968 0.643 rs524012 chr2:219433273 T/G cg02176678 chr2:219576539 TTLL4 0.64 11.85 0.54 2.83e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs400736 0.562 rs10864331 chr1:8172178 A/G cg25007680 chr1:8021821 PARK7 -0.4 -6.06 -0.31 3.78e-9 Response to antidepressants and depression; LUSC cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs3114020 0.739 rs2622627 chr4:89065353 C/A cg19815589 chr11:70709062 SHANK2 -0.34 -6.12 -0.32 2.56e-9 Gout; LUSC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg12963246 chr6:28129442 ZNF389 0.52 7.33 0.37 1.8e-12 Parkinson's disease; LUSC cis rs4474465 0.790 rs4945290 chr11:78252249 C/T cg27205649 chr11:78285834 NARS2 0.52 6.28 0.33 1.02e-9 Alzheimer's disease (survival time); LUSC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg20891558 chr2:74357851 NA -0.77 -13.63 -0.6 6.11e-34 Gestational age at birth (maternal effect); LUSC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.29e-12 Developmental language disorder (linguistic errors); LUSC cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg11266682 chr4:10021025 SLC2A9 0.51 9.32 0.45 1.61e-18 Bone mineral density; LUSC cis rs79839061 0.520 rs11730111 chr4:942833 C/T cg23992470 chr4:843637 GAK 0.55 5.84 0.3 1.25e-8 Intelligence (multi-trait analysis); LUSC cis rs17685 0.753 rs11972240 chr7:75694079 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.67 -0.39 1.96e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7561273 0.609 rs2160943 chr2:24288775 G/A cg20701182 chr2:24300061 SF3B14 0.45 5.77 0.3 1.76e-8 Quantitative traits; LUSC cis rs7615316 1.000 rs9866958 chr3:142338441 T/C cg16271453 chr3:142027066 XRN1 -0.35 -5.87 -0.31 1.02e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs73416724 0.925 rs112053368 chr6:43382960 C/A cg26312998 chr6:43337775 ZNF318 0.53 6.15 0.32 2.23e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs17854409 1.000 rs6010770 chr20:61494225 G/T cg05147244 chr20:61493195 TCFL5 0.93 7.49 0.38 6.04e-13 Obesity-related traits; LUSC cis rs1215050 0.740 rs783963 chr4:98989070 A/G cg05340658 chr4:99064831 C4orf37 0.47 7.55 0.38 4.08e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs10761482 0.861 rs4456215 chr10:62103249 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs8060686 0.545 rs9922165 chr16:68181177 C/A cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg01802117 chr1:53393560 SCP2 -0.4 -6.63 -0.34 1.32e-10 Monocyte count; LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.85 -0.58 5.44e-31 Alzheimer's disease; LUSC cis rs4242434 0.927 rs34027561 chr8:22465385 T/C cg03733263 chr8:22462867 KIAA1967 0.99 18.01 0.7 3.63e-51 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg24503407 chr1:205819492 PM20D1 0.89 16.53 0.67 2.94e-45 Menarche (age at onset); LUSC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg18230493 chr5:56204884 C5orf35 -0.97 -14.41 -0.62 6.28e-37 Initial pursuit acceleration; LUSC trans rs2055729 0.645 rs62489486 chr8:9741925 G/A cg15556689 chr8:8085844 FLJ10661 0.51 6.14 0.32 2.35e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs11250098 0.547 rs2409764 chr8:11281273 C/T cg15556689 chr8:8085844 FLJ10661 0.55 8.04 0.4 1.56e-14 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg13560548 chr3:10150139 C3orf24 0.47 6.65 0.34 1.18e-10 Alzheimer's disease; LUSC cis rs9479482 1.000 rs9478354 chr6:150334366 G/A cg03788504 chr6:150331562 NA -0.27 -6.03 -0.31 4.29e-9 Alopecia areata; LUSC cis rs7119038 0.818 rs6421571 chr11:118743772 T/C cg19308663 chr11:118741387 NA -0.33 -5.78 -0.3 1.75e-8 Sjögren's syndrome; LUSC cis rs36093844 0.800 rs17744711 chr11:85600724 T/C cg25872744 chr11:85566296 CCDC83 -0.44 -5.65 -0.3 3.43e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs1371867 0.817 rs1788208 chr8:101312515 T/C cg00191853 chr8:101177733 SPAG1 -0.41 -6.59 -0.34 1.68e-10 Atrioventricular conduction; LUSC cis rs7084921 0.579 rs11596253 chr10:101849411 C/A cg11888571 chr10:102027403 CWF19L1 -0.47 -6.36 -0.33 6.53e-10 Bone mineral density; LUSC cis rs3784262 0.967 rs12910752 chr15:58314679 G/A cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.67 -0.3 3.02e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs4727027 0.782 rs10245343 chr7:148796333 T/C cg23158103 chr7:148848205 ZNF398 -0.41 -6.01 -0.31 4.95e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.66 -0.39 1.97e-13 Lymphocyte counts; LUSC cis rs1865760 0.566 rs9379825 chr6:26083871 C/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs11098499 0.754 rs9999724 chr4:120239944 C/T cg09307838 chr4:120376055 NA 0.69 10.48 0.5 2.11e-22 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01198024 chr21:33672713 MRAP -0.41 -6.9 -0.35 2.7e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs908922 0.676 rs498184 chr1:152501423 G/C cg20991723 chr1:152506922 NA 0.49 9.08 0.44 9.93e-18 Hair morphology; LUSC cis rs12410462 0.681 rs115956039 chr1:227661978 G/A cg04117972 chr1:227635322 NA 0.77 7.74 0.39 1.17e-13 Major depressive disorder; LUSC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg12463550 chr7:65579703 CRCP 0.5 7.02 0.36 1.22e-11 Aortic root size; LUSC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg13206674 chr6:150067644 NUP43 0.56 8.86 0.44 4.74e-17 Lung cancer; LUSC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg03433033 chr1:76189801 ACADM -0.74 -10.11 -0.48 3.83e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg12667521 chr19:29218732 NA 0.56 7.24 0.37 3.12e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg18876405 chr7:65276391 NA -0.68 -12.23 -0.56 1.11e-28 Aortic root size; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06888554 chr19:42580220 ZNF574 0.7 6.06 0.31 3.71e-9 Cognitive performance; LUSC cis rs6845621 0.870 rs13114606 chr4:18930791 A/C cg12196642 chr4:18937545 NA -0.36 -6.69 -0.34 9.3e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs941408 0.515 rs7253128 chr19:2776982 C/T cg22153745 chr1:153894579 GATAD2B -0.49 -6.85 -0.35 3.54e-11 Total cholesterol levels; LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg21782813 chr7:2030301 MAD1L1 0.48 8.04 0.4 1.59e-14 Bipolar disorder and schizophrenia; LUSC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg11764359 chr7:65958608 NA -0.78 -13.04 -0.58 1.05e-31 Aortic root size; LUSC cis rs4803468 1.000 rs10422956 chr19:41901261 C/T cg09537434 chr19:41945824 ATP5SL -0.89 -15.79 -0.65 2.36e-42 Height; LUSC cis rs7980687 0.574 rs10744149 chr12:123708490 T/A cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Height;Educational attainment;Head circumference (infant); LUSC cis rs9420 0.961 rs708228 chr11:57585662 C/T cg23127183 chr11:57508653 C11orf31 -0.57 -8.69 -0.43 1.7e-16 Schizophrenia; LUSC cis rs17685 0.753 rs1859791 chr7:75786043 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg00129232 chr17:37814104 STARD3 -0.5 -7.49 -0.38 6.21e-13 Asthma; LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg06636001 chr8:8085503 FLJ10661 -0.4 -6.09 -0.32 3.17e-9 Neuroticism; LUSC trans rs7939886 0.920 rs17150102 chr11:55904382 A/C cg03929089 chr4:120376271 NA 0.77 6.09 0.32 3.03e-9 Myopia (pathological); LUSC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg01097406 chr16:89675127 NA -0.36 -7.11 -0.36 7.29e-12 Vitiligo; LUSC trans rs2898290 0.694 rs2248909 chr8:11392093 A/C cg11608241 chr8:8085544 FLJ10661 -0.42 -6.14 -0.32 2.35e-9 Systolic blood pressure; LUSC trans rs35110281 0.782 rs2051407 chr21:45079245 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.09 0.52 1.58e-24 Mean corpuscular volume; LUSC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg18876405 chr7:65276391 NA -0.55 -8.65 -0.43 2.17e-16 Aortic root size; LUSC cis rs7647973 1.000 rs73088137 chr3:49448423 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.49 -7.31 -0.37 1.96e-12 Menarche (age at onset); LUSC trans rs61931739 0.534 rs4931775 chr12:34050729 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.36 0.53 1.66e-25 Morning vs. evening chronotype; LUSC cis rs7508 0.511 rs208026 chr8:17878155 A/G cg01800426 chr8:17659068 MTUS1 -0.52 -6.26 -0.32 1.17e-9 Atrial fibrillation; LUSC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg22920501 chr2:26401640 FAM59B 0.7 9.1 0.45 8.43e-18 Gut microbiome composition (summer); LUSC cis rs7169223 0.653 rs1994017 chr15:79080306 T/C cg21242079 chr15:79101063 ADAMTS7 0.38 5.76 0.3 1.91e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg17971929 chr21:40555470 PSMG1 0.8 14.27 0.62 2.18e-36 Cognitive function; LUSC trans rs10506458 0.915 rs2013042 chr12:63394211 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.64 -0.65 9.62e-42 Hemostatic factors and hematological phenotypes; LUSC cis rs4595586 0.525 rs7313120 chr12:39388027 A/G cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.13 0.32 2.46e-9 Menopause (age at onset); LUSC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.6 -8.61 -0.43 2.99e-16 Mean platelet volume; LUSC cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg00745463 chr17:30367425 LRRC37B 0.79 8.4 0.42 1.28e-15 Hip circumference adjusted for BMI; LUSC cis rs6489882 0.836 rs2384071 chr12:113367343 A/G cg20102336 chr12:113376681 OAS3 -0.42 -5.96 -0.31 6.39e-9 Chronic lymphocytic leukemia; LUSC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg22681709 chr2:178499509 PDE11A -0.51 -9.13 -0.45 6.86e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4363385 0.588 rs11586559 chr1:153025714 G/A cg00922841 chr1:152955080 SPRR1A -0.38 -6.28 -0.32 1.06e-9 Inflammatory skin disease; LUSC cis rs6424115 0.867 rs10917431 chr1:24174093 T/G cg10978503 chr1:24200527 CNR2 -0.53 -12.52 -0.57 9.21e-30 Immature fraction of reticulocytes; LUSC cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg00071950 chr4:10020882 SLC2A9 0.49 7.89 0.4 4.26e-14 Bone mineral density; LUSC cis rs7267979 0.789 rs6083820 chr20:25354178 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.76 -15.5 -0.65 3.44e-41 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg21211367 chr2:162094118 NA 0.44 7.04 0.36 1.12e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs4588572 0.643 rs6861678 chr5:77764613 G/C cg11547950 chr5:77652471 NA -0.56 -7.9 -0.4 4.03e-14 Triglycerides; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17404403 chr4:110737017 GAR1 -0.53 -6.87 -0.35 3.13e-11 Bipolar disorder and schizophrenia; LUSC cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.85 -0.51 1.03e-23 Alzheimer's disease (late onset); LUSC cis rs1823874 0.720 rs1993296 chr15:100363588 T/A cg16400843 chr15:100339927 C15orf51 0.36 6.99 0.36 1.53e-11 IgG glycosylation; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02310562 chr12:117348663 FBXW8 0.38 6.12 0.32 2.66e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg14703610 chr5:56206110 C5orf35 -0.41 -6.13 -0.32 2.51e-9 Coronary artery disease; LUSC cis rs394563 0.601 rs432582 chr6:149794143 C/T cg11245181 chr6:149772854 ZC3H12D -0.35 -7.08 -0.36 8.58e-12 Dupuytren's disease; LUSC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.54 0.34 2.26e-10 Lung cancer; LUSC cis rs8017423 1.000 rs59052550 chr14:90665098 C/T cg04374321 chr14:90722782 PSMC1 0.67 10.43 0.5 3.08e-22 Mortality in heart failure; LUSC cis rs2204008 0.630 rs12306932 chr12:38242029 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.46 -0.42 8.45e-16 Bladder cancer; LUSC trans rs2243480 1.000 rs12698509 chr7:65418876 C/T cg10756647 chr7:56101905 PSPH 0.84 8.5 0.42 6.25e-16 Diabetic kidney disease; LUSC cis rs1949733 0.598 rs869602 chr4:8535371 G/T cg13073564 chr4:8508604 NA 0.34 6.29 0.33 1e-9 Response to antineoplastic agents; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg03579872 chr1:53393473 SCP2 0.39 5.67 0.3 3.16e-8 Monocyte count; LUSC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg19257562 chr1:2043853 PRKCZ 0.33 6.7 0.34 8.87e-11 Height; LUSC cis rs3018712 0.590 rs4930236 chr11:68414000 C/A cg22747802 chr11:68417633 NA -0.4 -5.64 -0.3 3.57e-8 Total body bone mineral density; LUSC cis rs12188164 0.932 rs2230437 chr5:476353 C/T cg00049323 chr5:472564 LOC25845 -0.43 -6.78 -0.35 5.41e-11 Cystic fibrosis severity; LUSC cis rs716595 1.000 rs72830450 chr10:111989086 G/T cg13996003 chr10:112034540 MXI1 -0.7 -5.81 -0.3 1.42e-8 Normalized brain volume; LUSC cis rs1957429 0.614 rs78603758 chr14:65396648 C/G cg23373153 chr14:65346875 NA -0.98 -7.73 -0.39 1.3e-13 Pediatric areal bone mineral density (radius); LUSC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC trans rs984440 0.535 rs1325057 chr8:139076027 G/A cg03334052 chr1:168888044 NA 0.41 6.48 0.33 3.22e-10 Obesity-related traits; LUSC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg24733560 chr20:60626293 TAF4 0.41 6.69 0.34 9.26e-11 Body mass index; LUSC cis rs11676348 0.772 rs10932745 chr2:218942976 T/C cg00012203 chr2:219082015 ARPC2 -0.47 -7.08 -0.36 8.41e-12 Ulcerative colitis; LUSC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg22105103 chr4:187893119 NA 0.71 13.43 0.59 3.66e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.909 rs6060923 chr20:30336655 A/C cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg22903471 chr2:27725779 GCKR -0.39 -6.58 -0.34 1.86e-10 Total body bone mineral density; LUSC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg05084668 chr3:125655381 ALG1L -0.53 -8.03 -0.4 1.71e-14 Blood pressure (smoking interaction); LUSC cis rs34779708 0.931 rs12268745 chr10:35305989 C/G cg04310649 chr10:35416472 CREM -0.4 -6.1 -0.32 2.95e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11055034 0.560 rs2024385 chr12:12888438 A/T cg04607235 chr12:12878440 APOLD1 0.61 10.11 0.48 4e-21 Birth weight; LUSC cis rs9747201 0.962 rs62079995 chr17:80076624 C/T cg17462356 chr17:80056334 FASN 0.46 5.95 0.31 6.81e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6539288 0.500 rs11113116 chr12:107195929 C/A cg15890332 chr12:107067104 RFX4 0.36 6.57 0.34 1.89e-10 Total body bone mineral density; LUSC cis rs7512552 0.966 rs2274127 chr1:150252984 T/G cg15654264 chr1:150340011 RPRD2 -0.62 -9.95 -0.48 1.36e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs11971779 0.680 rs1862879 chr7:139019951 A/G cg07862535 chr7:139043722 LUC7L2 0.55 6.83 0.35 4.09e-11 Diisocyanate-induced asthma; LUSC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg04450456 chr4:17643702 FAM184B 0.42 7.09 0.36 8.02e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2439831 1.000 rs690263 chr15:43704465 C/G cg02155558 chr15:43621948 ADAL;LCMT2 1.01 11.53 0.53 3.97e-26 Lung cancer in ever smokers; LUSC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg24154853 chr7:158122151 PTPRN2 0.44 8.28 0.41 2.91e-15 Calcium levels; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg07362569 chr17:61921086 SMARCD2 0.38 7.98 0.4 2.33e-14 Prudent dietary pattern; LUSC cis rs977987 0.778 rs11858992 chr16:75411445 A/C cg04384234 chr16:75411784 CFDP1 -0.44 -7.28 -0.37 2.4e-12 Dupuytren's disease; LUSC cis rs9648716 0.515 rs246739 chr7:140687173 A/T cg23214464 chr7:140373596 ADCK2 0.7 5.92 0.31 7.78e-9 Type 2 diabetes; LUSC cis rs17125944 0.572 rs79312783 chr14:53250296 A/T cg13660082 chr14:53194042 PSMC6 -0.78 -6.43 -0.33 4.36e-10 Alzheimer's disease (late onset); LUSC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC cis rs1783925 1.000 rs2845845 chr11:125303663 A/G cg03464685 chr11:125439445 EI24 -0.48 -6.49 -0.33 3.09e-10 Formal thought disorder in schizophrenia; LUSC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg20090143 chr19:45452003 APOC2 0.47 9.37 0.46 1.11e-18 Blood protein levels; LUSC cis rs568617 0.953 rs1151519 chr11:65645831 G/C cg04055107 chr11:65626734 MUS81;CFL1 -0.51 -6.14 -0.32 2.39e-9 Crohn's disease; LUSC cis rs10078 0.528 rs2434697 chr5:466811 T/C cg08916839 chr5:415575 AHRR 0.76 7.1 0.36 7.48e-12 Fat distribution (HIV); LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg22907277 chr7:1156413 C7orf50 0.71 7.44 0.38 8.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2688608 0.934 rs2675679 chr10:75658581 C/T cg23231163 chr10:75533350 FUT11 -0.39 -6.5 -0.34 2.91e-10 Inflammatory bowel disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00576402 chr7:77167212 PTPN12 -0.41 -6.2 -0.32 1.69e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6964587 1.000 rs2282972 chr7:91666369 C/T cg17063962 chr7:91808500 NA 0.6 9.34 0.45 1.43e-18 Breast cancer; LUSC trans rs11098499 0.754 rs1980027 chr4:120251577 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.42 0.33 4.62e-10 Corneal astigmatism; LUSC cis rs9393777 0.720 rs35212793 chr6:26998693 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -5.82 -0.3 1.35e-8 Intelligence (multi-trait analysis); LUSC trans rs853679 0.567 rs6905380 chr6:28374902 A/G cg06606381 chr12:133084897 FBRSL1 -0.41 -5.98 -0.31 5.67e-9 Depression; LUSC cis rs208520 0.955 rs28684412 chr6:66979430 A/C cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg08859206 chr1:53392774 SCP2 -0.55 -9.79 -0.47 4.76e-20 Monocyte count; LUSC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.67 8.69 0.43 1.71e-16 Schizophrenia; LUSC cis rs9902453 0.935 rs9898424 chr17:28392946 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.72 -0.43 1.29e-16 Coffee consumption (cups per day); LUSC cis rs6430585 0.941 rs60963894 chr2:136539670 T/G cg07169764 chr2:136633963 MCM6 0.87 11.91 0.55 1.67e-27 Corneal structure; LUSC cis rs2404602 0.692 rs67570291 chr15:77020502 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.81e-12 Blood metabolite levels; LUSC cis rs11098499 0.863 rs7657849 chr4:120455494 T/C cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg03929089 chr4:120376271 NA -1.03 -19.86 -0.74 1.61e-58 Height; LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg15790184 chr11:494944 RNH1 0.59 6.22 0.32 1.49e-9 Body mass index; LUSC cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg24558204 chr6:135376177 HBS1L 0.67 10.12 0.48 3.55e-21 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg13047869 chr3:10149882 C3orf24 0.63 8.72 0.43 1.31e-16 Alzheimer's disease; LUSC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg19622623 chr12:86230825 RASSF9 0.4 5.8 0.3 1.56e-8 Major depressive disorder; LUSC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg26380479 chr7:97908229 NA 0.29 6.68 0.34 1.03e-10 Prostate cancer (SNP x SNP interaction); LUSC trans rs7829975 0.514 rs2979151 chr8:8258019 A/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.42 -0.33 4.57e-10 Mood instability; LUSC cis rs154659 0.887 rs154660 chr16:89667637 C/G cg01710450 chr16:89662404 CPNE7 -0.41 -6.2 -0.32 1.67e-9 Tanning; LUSC cis rs1691799 0.863 rs1168291 chr12:66732488 T/C cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.33e-31 White blood cell count (basophil); LUSC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg27427491 chr17:78079615 GAA 0.45 7.76 0.39 1.06e-13 Yeast infection; LUSC cis rs4595586 0.505 rs11615603 chr12:39409450 C/G cg13010199 chr12:38710504 ALG10B 0.42 6.16 0.32 2.05e-9 Morning vs. evening chronotype; LUSC cis rs7577696 0.597 rs13006495 chr2:32355490 C/T cg02381751 chr2:32503542 YIPF4 -0.53 -7.07 -0.36 8.97e-12 Inflammatory biomarkers; LUSC trans rs561341 0.883 rs4795661 chr17:30201774 T/A cg27661571 chr11:113659931 NA 0.59 6.42 0.33 4.67e-10 Hip circumference adjusted for BMI; LUSC trans rs2679649 1.000 rs2679688 chr6:122362802 A/G cg00167820 chr8:131663355 NA 0.53 6.2 0.32 1.68e-9 Subcutaneous adipose tissue; LUSC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.4 -6.28 -0.32 1.08e-9 Total body bone mineral density; LUSC trans rs9329221 0.662 rs34155841 chr8:10247529 T/G cg06636001 chr8:8085503 FLJ10661 0.55 7.5 0.38 5.78e-13 Neuroticism; LUSC trans rs7618501 0.633 rs35065728 chr3:50009176 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.53 8.4 0.42 1.3e-15 Intelligence (multi-trait analysis); LUSC cis rs6815814 0.950 rs5743580 chr4:38804405 C/T cg02016764 chr4:38805732 TLR1 -0.53 -5.74 -0.3 2.16e-8 Breast cancer; LUSC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg13047869 chr3:10149882 C3orf24 0.56 7.73 0.39 1.24e-13 Alzheimer's disease; LUSC cis rs4740619 0.905 rs4146291 chr9:15783266 C/T cg14451791 chr9:16040625 NA -0.3 -5.65 -0.3 3.48e-8 Body mass index; LUSC cis rs10779751 0.726 rs1205593 chr1:11252716 T/C cg08854313 chr1:11322531 MTOR 0.84 12.82 0.57 6.91e-31 Body mass index; LUSC cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg03676636 chr4:99064102 C4orf37 0.36 7.86 0.4 5.37e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11758351 0.778 rs41266801 chr6:26197493 C/A cg23601095 chr6:26197514 HIST1H3D 0.73 7.49 0.38 6.15e-13 Gout;Renal underexcretion gout; LUSC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg21017887 chr14:105400489 NA 0.69 13.26 0.59 1.5e-32 Rheumatoid arthritis; LUSC cis rs4631830 0.863 rs10826125 chr10:51530505 G/A cg16070123 chr10:51489643 NA -0.5 -7.96 -0.4 2.78e-14 Prostate-specific antigen levels; LUSC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg05347473 chr6:146136440 FBXO30 0.65 11.21 0.52 5.68e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4400599 0.618 rs9804045 chr1:154191691 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 0.37 6.18 0.32 1.86e-9 Platelet distribution width; LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg16405210 chr4:1374714 KIAA1530 0.71 10.97 0.51 4.05e-24 Obesity-related traits; LUSC cis rs394563 0.663 rs415434 chr6:149772645 A/G cg11245181 chr6:149772854 ZC3H12D -0.31 -6.7 -0.34 9.06e-11 Dupuytren's disease; LUSC cis rs4555082 0.915 rs28594491 chr14:105758018 G/A cg13114125 chr14:105738426 BRF1 -0.87 -14.49 -0.62 3.07e-37 Mean platelet volume;Platelet distribution width; LUSC cis rs3862030 0.694 rs2025712 chr10:104230064 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.97 -0.44 2.18e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs117623576 0.941 rs7070675 chr10:32407269 G/T cg03047570 chr10:32398778 NA -0.63 -6.05 -0.31 3.83e-9 Anti-saccade response; LUSC cis rs11031096 0.655 rs56172516 chr11:4182004 G/T cg18678763 chr11:4115507 RRM1 -0.4 -5.67 -0.3 3.07e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9814567 1.000 rs7637227 chr3:134244155 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg17252645 chr8:143867129 LY6D 0.37 6.61 0.34 1.54e-10 Urinary tract infection frequency; LUSC cis rs7119 0.651 rs12905044 chr15:77846215 G/A cg27398640 chr15:77910606 LINGO1 -0.32 -6.92 -0.35 2.32e-11 Type 2 diabetes; LUSC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg26314531 chr2:26401878 FAM59B 0.71 9.78 0.47 4.98e-20 Gut microbiome composition (summer); LUSC cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.05e-43 Bladder cancer; LUSC cis rs12618769 0.597 rs72821924 chr2:99114924 C/T cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg12923728 chr3:195709715 SDHAP1 -0.79 -12.47 -0.56 1.41e-29 Pancreatic cancer; LUSC cis rs1790761 0.692 rs638140 chr11:67333858 G/C cg00290607 chr11:67383545 NA 0.36 6.7 0.34 9.12e-11 Mean corpuscular volume; LUSC cis rs7267979 0.866 rs2424698 chr20:25256106 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.8 16.84 0.68 1.75e-46 Liver enzyme levels (alkaline phosphatase); LUSC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg11871910 chr12:69753446 YEATS4 0.61 9.08 0.44 9.9e-18 Response to diuretic therapy; LUSC cis rs11688816 0.569 rs7591708 chr2:63022050 T/C cg17519650 chr2:63277830 OTX1 -0.6 -8.02 -0.4 1.82e-14 Body mass index; LUSC cis rs36093844 0.904 rs1445502 chr11:85589298 T/A cg25872744 chr11:85566296 CCDC83 -0.42 -6.84 -0.35 3.7e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6681460 0.634 rs12143964 chr1:67010266 T/G cg02459107 chr1:67143332 SGIP1 0.38 6.35 0.33 7.19e-10 Presence of antiphospholipid antibodies; LUSC trans rs656319 0.605 rs17747335 chr8:10003186 A/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.15 -0.36 5.58e-12 Myopia (pathological); LUSC cis rs614226 1.000 rs1167726 chr12:120967364 A/C cg21053147 chr12:120880522 NA 0.49 5.99 0.31 5.52e-9 Type 1 diabetes nephropathy; LUSC cis rs9486719 1.000 rs2142653 chr6:96871520 C/A cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC trans rs7824557 0.602 rs11784544 chr8:11204503 G/C cg06636001 chr8:8085503 FLJ10661 0.45 6.42 0.33 4.57e-10 Retinal vascular caliber; LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg07138452 chr17:17141020 FLCN 0.37 6.1 0.32 2.89e-9 Bladder cancer; LUSC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg05025164 chr4:1340916 KIAA1530 0.54 8.61 0.43 3.03e-16 Longevity; LUSC cis rs9393777 0.623 rs9358947 chr6:26479000 G/A cg12292205 chr6:26970375 C6orf41 -0.63 -7.57 -0.38 3.72e-13 Intelligence (multi-trait analysis); LUSC cis rs6084875 0.840 rs2249483 chr20:4719176 C/T cg07258627 chr20:4721683 PRNT -0.34 -6.06 -0.31 3.75e-9 Systemic lupus erythematosus; LUSC cis rs9467773 0.583 rs1021373 chr6:26632457 G/A cg11502198 chr6:26597334 ABT1 0.71 12.06 0.55 4.63e-28 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg00033643 chr7:134001901 SLC35B4 0.46 7.09 0.36 7.8e-12 Mean platelet volume; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg03461704 chr1:205818484 PM20D1 0.36 5.78 0.3 1.69e-8 Menarche (age at onset); LUSC cis rs317689 0.718 rs645026 chr12:69757931 G/A cg14784868 chr12:69753453 YEATS4 0.58 7.37 0.37 1.33e-12 Response to diuretic therapy; LUSC cis rs2820315 0.867 rs2644121 chr1:201881284 A/G cg10061532 chr1:201886748 LMOD1 0.28 6.42 0.33 4.65e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg17971929 chr21:40555470 PSMG1 0.77 12.79 0.57 8.89e-31 Cognitive function; LUSC cis rs7769051 0.522 rs57176306 chr6:133142168 C/T cg07930552 chr6:133119739 C6orf192 0.97 9.55 0.46 2.92e-19 Type 2 diabetes nephropathy; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.38 -0.42 1.45e-15 Lymphocyte counts; LUSC trans rs4295623 0.553 rs11250163 chr8:11596437 G/T cg15556689 chr8:8085844 FLJ10661 0.47 7.03 0.36 1.19e-11 Morning vs. evening chronotype; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg15112475 chr7:1198522 ZFAND2A -0.34 -7.27 -0.37 2.63e-12 Longevity;Endometriosis; LUSC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg05872129 chr22:39784769 NA -0.62 -11.84 -0.54 3e-27 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.02 -0.4 1.85e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg22963979 chr7:1858916 MAD1L1 -0.6 -9.47 -0.46 5.33e-19 Bipolar disorder and schizophrenia; LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg13560548 chr3:10150139 C3orf24 0.5 7.09 0.36 8.1e-12 Alzheimer's disease; LUSC cis rs8017423 0.967 rs7147952 chr14:90720831 G/A cg14092571 chr14:90743983 NA -0.35 -5.81 -0.3 1.47e-8 Mortality in heart failure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23868899 chr8:124553478 FBXO32 -0.42 -6.26 -0.32 1.15e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10193935 1.000 rs12612527 chr2:42392099 T/C cg27598129 chr2:42591480 NA -0.65 -8.29 -0.41 2.73e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.821 rs72796378 chr2:24167385 G/A cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs7267979 1.000 rs2482937 chr20:25340786 A/G cg03522245 chr20:25566470 NINL -0.36 -5.75 -0.3 2.02e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.16 -0.32 2.13e-9 Life satisfaction; LUSC trans rs1814175 0.817 rs2866545 chr11:49630824 A/C cg15704280 chr7:45808275 SEPT13 -1.1 -23.72 -0.79 1.27e-73 Height; LUSC cis rs9815354 0.812 rs11129932 chr3:41838767 C/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs3737883 1.000 rs3737883 chr1:203034906 C/T cg00805880 chr1:203045044 PPFIA4 0.29 5.93 0.31 7.36e-9 Early onset atrial fibrillation; LUSC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg07424592 chr7:64974309 NA 0.69 6.08 0.32 3.31e-9 Diabetic kidney disease; LUSC cis rs2089162 1 rs2089162 chr15:78739763 A/G cg18825076 chr15:78729989 IREB2 -0.62 -10.03 -0.48 7.25e-21 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs12220238 1.000 rs7909915 chr10:75960942 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.12e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg15309053 chr8:964076 NA -0.4 -8.17 -0.41 6.57e-15 Schizophrenia; LUSC cis rs6977660 0.619 rs4721823 chr7:19785888 G/C cg07541023 chr7:19748670 TWISTNB 0.57 5.92 0.31 7.83e-9 Thyroid stimulating hormone; LUSC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg23590916 chr17:43697445 MGC57346 -0.46 -6.14 -0.32 2.33e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8180040 0.726 rs4682837 chr3:46999707 C/T cg27129171 chr3:47204927 SETD2 0.74 12.88 0.58 4.16e-31 Colorectal cancer; LUSC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg11663144 chr21:46675770 NA -0.4 -6.55 -0.34 2.12e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1376359 0.537 rs2244031 chr1:103257185 C/G cg17154563 chr19:40477487 PSMC4 0.48 6.05 0.31 3.79e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg05585544 chr11:47624801 NA 0.41 7.39 0.37 1.22e-12 Subjective well-being; LUSC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg15445000 chr17:37608096 MED1 0.37 6.46 0.33 3.76e-10 Glomerular filtration rate (creatinine); LUSC cis rs7568458 0.704 rs10176176 chr2:85762048 A/T cg23752985 chr2:85803571 VAMP8 0.28 5.78 0.3 1.68e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.79 0.39 8.3e-14 Lymphocyte counts; LUSC cis rs11098499 0.954 rs12502423 chr4:120424172 A/C cg24375607 chr4:120327624 NA 0.8 12.39 0.56 2.79e-29 Corneal astigmatism; LUSC cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg23711669 chr6:146136114 FBXO30 0.74 13.07 0.58 7.88e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.6 8.66 0.43 2.06e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9837602 1.000 rs793499 chr3:99565576 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -5.74 -0.3 2.15e-8 Breast cancer; LUSC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg24881330 chr22:46731750 TRMU 0.84 7.39 0.37 1.22e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs1003719 0.715 rs2835659 chr21:38567902 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.2 -0.49 1.9e-21 Eye color traits; LUSC cis rs8027181 1.000 rs4777542 chr15:73082366 C/T cg25632853 chr15:73088954 NA -0.34 -6.61 -0.34 1.56e-10 Triglyceride levels; LUSC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg12963246 chr6:28129442 ZNF389 0.52 7.16 0.36 5.3e-12 Depression; LUSC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg00343986 chr7:65444356 GUSB -0.44 -6.74 -0.35 6.83e-11 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08189659 chr19:17622568 PGLS -0.41 -6.1 -0.32 2.9e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg25767906 chr1:53392781 SCP2 0.49 8.71 0.43 1.4e-16 Monocyte count; LUSC cis rs12208915 0.945 rs12190108 chr6:79562655 T/C cg05283184 chr6:79620031 NA 0.46 5.97 0.31 5.97e-9 Left atrial antero-posterior diameter; LUSC cis rs11828289 0.660 rs79067807 chr11:23228262 T/C cg20040320 chr11:23191996 NA -0.61 -6.2 -0.32 1.69e-9 Cancer; LUSC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg04369109 chr6:150039330 LATS1 -0.55 -8.18 -0.41 5.94e-15 Lung cancer; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -11.86 -0.54 2.57e-27 Alzheimer's disease; LUSC cis rs6495122 0.501 rs8039755 chr15:75337426 T/C cg09165964 chr15:75287851 SCAMP5 -0.48 -6.94 -0.36 2e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg21724239 chr8:58056113 NA 0.88 9.73 0.47 7.33e-20 Developmental language disorder (linguistic errors); LUSC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg21984481 chr17:79567631 NPLOC4 0.68 14.41 0.62 5.81e-37 Eye color traits; LUSC trans rs208515 0.556 rs1872309 chr6:66660432 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 11.04 0.52 2.31e-24 Exhaled nitric oxide levels; LUSC cis rs559928 0.593 rs112275221 chr11:63936994 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.25 0.37 2.93e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7815909 0.610 rs11987972 chr8:57205975 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.24 0.37 3.02e-12 Height; LUSC cis rs7584330 0.784 rs6724766 chr2:238413600 A/G cg14458575 chr2:238380390 NA 0.63 10.49 0.5 1.91e-22 Prostate cancer; LUSC trans rs7824557 0.628 rs11777746 chr8:11204755 T/C cg06636001 chr8:8085503 FLJ10661 0.46 6.66 0.34 1.14e-10 Retinal vascular caliber; LUSC cis rs208515 0.556 rs12214562 chr6:66681011 T/A cg07460842 chr6:66804631 NA 1.05 14.32 0.62 1.33e-36 Exhaled nitric oxide levels; LUSC trans rs1814175 0.645 rs28478790 chr11:50054322 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs6496667 0.509 rs2657948 chr15:90948617 G/A cg10434728 chr15:90938212 IQGAP1 0.34 6.55 0.34 2.19e-10 Rheumatoid arthritis; LUSC cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg00071950 chr4:10020882 SLC2A9 0.54 9.09 0.45 8.92e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg18099408 chr3:52552593 STAB1 -0.34 -5.85 -0.3 1.19e-8 Bipolar disorder; LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.46 -0.42 8.46e-16 Bipolar disorder; LUSC cis rs9311676 0.632 rs11924677 chr3:58420542 T/C cg26110898 chr3:58419937 PDHB 0.4 6.4 0.33 5.22e-10 Systemic lupus erythematosus; LUSC cis rs10887741 0.624 rs6586092 chr10:89428994 A/T cg13926569 chr10:89418898 PAPSS2 0.33 7.21 0.37 3.88e-12 Exercise (leisure time); LUSC trans rs7647973 0.587 rs10452032 chr3:49680973 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.87 -0.35 3.11e-11 Menarche (age at onset); LUSC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg15445000 chr17:37608096 MED1 -0.4 -6.79 -0.35 5.14e-11 Glomerular filtration rate (creatinine); LUSC cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.15e-8 Breast cancer; LUSC cis rs1215050 0.740 rs10025482 chr4:99053277 T/C cg05340658 chr4:99064831 C4orf37 0.46 7.29 0.37 2.23e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg02423579 chr7:2872169 GNA12 -0.5 -7.14 -0.36 5.96e-12 Height; LUSC cis rs7833986 0.501 rs72653978 chr8:57018393 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.16 0.55 1.98e-28 Height; LUSC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg10560079 chr2:191398806 TMEM194B 0.44 7.38 0.37 1.24e-12 Pulse pressure; LUSC cis rs654950 0.840 rs2810551 chr1:41995402 G/A cg06885757 chr1:42089581 HIVEP3 -0.34 -6.55 -0.34 2.24e-10 Airway imaging phenotypes; LUSC cis rs2242116 0.592 rs6442039 chr3:46960797 C/G cg27129171 chr3:47204927 SETD2 0.55 6.77 0.35 5.9e-11 Birth weight; LUSC cis rs9527 0.545 rs11191602 chr10:104954219 C/T cg23093090 chr10:104574429 C10orf26 -0.34 -6.26 -0.32 1.19e-9 Arsenic metabolism; LUSC cis rs7818345 0.967 rs4391454 chr8:19275653 T/C cg11303988 chr8:19266685 CSGALNACT1 0.36 6.94 0.35 2.08e-11 Language performance in older adults (adjusted for episodic memory); LUSC trans rs77372450 0.551 rs11134891 chr5:157103373 G/A cg10450108 chr5:140208893 PCDHA6;PCDHA2;PCDHA1;PCDHA5;PCDHA3;PCDHA4 -0.53 -5.97 -0.31 6.01e-9 Bipolar disorder (body mass index interaction); LUSC cis rs76935404 1.000 rs76935404 chr19:41419294 C/T cg04176888 chr19:41596066 CYP2A13 0.39 6.15 0.32 2.17e-9 nicotine metabolite ratio in current smokers; LUSC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg19230755 chr7:65878503 NA 0.42 5.83 0.3 1.29e-8 Aortic root size; LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg02353165 chr6:42928485 GNMT 0.67 11.53 0.53 4.18e-26 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11583043 1.000 rs12750667 chr1:101498682 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.41 5.71 0.3 2.47e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg05025164 chr4:1340916 KIAA1530 0.44 6.87 0.35 3.13e-11 Obesity-related traits; LUSC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg14019146 chr3:50243930 SLC38A3 0.32 7.11 0.36 7.17e-12 Intelligence (multi-trait analysis); LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg04703951 chr17:43578652 NA 0.43 6.81 0.35 4.68e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg08219700 chr8:58056026 NA 0.47 5.94 0.31 7.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.95 -0.31 6.92e-9 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg02951883 chr7:2050386 MAD1L1 -0.56 -10.4 -0.49 3.82e-22 Bipolar disorder and schizophrenia; LUSC cis rs739401 0.611 rs450817 chr11:3056712 A/G cg08508325 chr11:3079039 CARS -0.53 -13.35 -0.59 7.16e-33 Longevity; LUSC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg12311346 chr5:56204834 C5orf35 -0.6 -9.27 -0.45 2.4e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs9517313 0.770 rs9517301 chr13:99095088 A/G cg20487152 chr13:99095054 FARP1 -0.48 -9.29 -0.45 2.02e-18 Neuroticism; LUSC trans rs7819412 1.000 rs7819412 chr8:11045161 A/G cg15556689 chr8:8085844 FLJ10661 0.55 8.26 0.41 3.4e-15 Triglycerides; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05061208 chr7:2281363 NUDT1;FTSJ2 -0.47 -6.11 -0.32 2.76e-9 Hepatitis; LUSC cis rs734999 0.588 rs2843403 chr1:2529097 T/C cg18932078 chr1:2524107 MMEL1 -0.29 -6.44 -0.33 4.14e-10 Ulcerative colitis; LUSC cis rs9916302 0.752 rs8071300 chr17:37508524 G/C cg07936489 chr17:37558343 FBXL20 0.8 9.85 0.47 2.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.64 0.5 5.85e-23 Bladder cancer; LUSC cis rs77633900 0.772 rs494268 chr15:76815713 T/C cg21673338 chr15:77095150 SCAPER -0.67 -5.71 -0.3 2.53e-8 Non-glioblastoma glioma;Glioma; LUSC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg13206674 chr6:150067644 NUP43 0.59 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs11098499 0.697 rs6832410 chr4:120296800 A/G cg09307838 chr4:120376055 NA 0.78 11.3 0.53 2.71e-25 Corneal astigmatism; LUSC cis rs1595825 0.945 rs73056890 chr2:198831260 A/G cg00982548 chr2:198649783 BOLL -0.58 -7.29 -0.37 2.32e-12 Ulcerative colitis; LUSC cis rs11190604 1.000 rs4919470 chr10:102298920 C/T cg16342193 chr10:102329863 NA -0.39 -6.81 -0.35 4.54e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2235649 0.789 rs9929803 chr16:1852748 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.13 -0.32 2.55e-9 Blood metabolite levels; LUSC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg09085632 chr11:111637200 PPP2R1B -1.05 -17.16 -0.68 8.97e-48 Primary sclerosing cholangitis; LUSC cis rs11711311 1.000 rs2603793 chr3:113496418 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.81 -0.3 1.48e-8 IgG glycosylation; LUSC trans rs561341 0.883 rs4450460 chr17:30201309 C/T cg20587970 chr11:113659929 NA 1.14 13.53 0.6 1.47e-33 Hip circumference adjusted for BMI; LUSC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg26897989 chr16:1907736 C16orf73 0.42 6.7 0.34 8.94e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs1568889 0.838 rs4572130 chr11:28371794 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.76 0.57 1.21e-30 Bipolar disorder; LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg13707768 chr11:65081977 CDC42EP2 -0.41 -6.38 -0.33 6.02e-10 QT interval (ambient particulate matter interaction); LUSC cis rs11867934 0.861 rs7217091 chr17:17060805 A/G cg26176665 chr17:16994978 MPRIP 0.42 6.06 0.31 3.74e-9 Diabetic retinopathy; LUSC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg20821713 chr7:1055600 C7orf50 -0.5 -6.29 -0.33 1.01e-9 Bronchopulmonary dysplasia; LUSC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.07 0.52 1.76e-24 Alzheimer's disease; LUSC cis rs1801251 1.000 rs10933412 chr2:233707226 G/C cg25237894 chr2:233734115 C2orf82 -0.37 -6.92 -0.35 2.34e-11 Coronary artery disease; LUSC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg02175503 chr12:58329896 NA 0.4 5.69 0.3 2.71e-8 Multiple sclerosis; LUSC cis rs7582720 1.000 rs72936353 chr2:204070956 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.38 0.42 1.54e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.5 7.61 0.38 2.87e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1451375 0.617 rs10277662 chr7:50594836 C/T cg18232548 chr7:50535776 DDC 0.55 7.44 0.38 8.74e-13 Malaria; LUSC cis rs7828089 0.935 rs2293144 chr8:22262418 A/G cg12081754 chr8:22256438 SLC39A14 0.54 8.47 0.42 8.05e-16 Verbal declarative memory; LUSC cis rs847649 0.699 rs7794668 chr7:102510416 C/T cg18108683 chr7:102477205 FBXL13 0.34 5.74 0.3 2.15e-8 Morning vs. evening chronotype; LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -6.07 -0.32 3.42e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7178572 0.962 rs1022172 chr15:77793359 A/G cg22256960 chr15:77711686 NA -0.55 -9.25 -0.45 2.69e-18 Type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg24352938 chr1:200008808 NR5A2 0.72 6.31 0.33 8.78e-10 Cognitive performance; LUSC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2237234 0.542 rs7755997 chr6:26483048 G/A cg12292205 chr6:26970375 C6orf41 0.43 6.86 0.35 3.29e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs8180040 0.593 rs10433549 chr3:47031433 C/T cg16586182 chr3:47516702 SCAP 0.52 7.99 0.4 2.23e-14 Colorectal cancer; LUSC cis rs6060717 0.536 rs6060683 chr20:34507921 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.74 -0.3 2.13e-8 Hip circumference adjusted for BMI; LUSC cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg04450456 chr4:17643702 FAM184B 0.34 5.68 0.3 2.89e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6977660 0.714 rs7357319 chr7:19817525 A/G cg07541023 chr7:19748670 TWISTNB 0.61 6.57 0.34 1.91e-10 Thyroid stimulating hormone; LUSC cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.33 -6.12 -0.32 2.61e-9 IgG glycosylation; LUSC cis rs7223966 0.921 rs2006123 chr17:61958669 G/T cg11494091 chr17:61959527 GH2 0.38 6.24 0.32 1.31e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7072216 0.763 rs6584202 chr10:100170383 G/A cg19567339 chr10:100142640 NA 0.38 5.66 0.3 3.2e-8 Metabolite levels; LUSC cis rs7503807 0.935 rs7215534 chr17:78612119 C/T cg09596252 chr17:78655493 RPTOR 0.45 7.75 0.39 1.15e-13 Obesity; LUSC cis rs9399135 0.967 rs4896125 chr6:135342569 C/T cg22676075 chr6:135203613 NA 0.47 7.4 0.38 1.12e-12 Red blood cell count; LUSC trans rs11681884 0.681 rs11883847 chr2:113792171 A/G cg19632953 chr13:113635898 MCF2L -0.69 -6.47 -0.33 3.52e-10 Stroke; LUSC cis rs477692 0.699 rs557311 chr10:131389484 A/G cg05714579 chr10:131428358 MGMT 0.45 6.3 0.33 9.35e-10 Response to temozolomide; LUSC cis rs61931739 0.500 rs34287388 chr12:34444626 C/A cg06521331 chr12:34319734 NA -0.4 -6.3 -0.33 9.13e-10 Morning vs. evening chronotype; LUSC cis rs7712401 0.601 rs34126945 chr5:122329729 A/G cg19077854 chr5:122220652 SNX24 -0.41 -8.93 -0.44 2.82e-17 Mean platelet volume; LUSC cis rs9517320 1.000 rs7994160 chr13:99132749 C/A cg07423050 chr13:99094983 FARP1 0.34 6.43 0.33 4.48e-10 Longevity; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg11062466 chr8:58055876 NA 0.65 8.39 0.42 1.41e-15 Developmental language disorder (linguistic errors); LUSC cis rs644799 0.511 rs10831420 chr11:95478209 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.53 7.17 0.37 4.89e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs113352275 1 rs113352275 chr15:78840567 C/T cg06917634 chr15:78832804 PSMA4 -0.57 -6.79 -0.35 5.2e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2108225 0.837 rs6958729 chr7:107451211 A/G cg18560240 chr7:107437656 SLC26A3 0.44 6.78 0.35 5.49e-11 Ulcerative colitis; LUSC cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg08085267 chr17:45401833 C17orf57 0.45 6.62 0.34 1.44e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs4942242 1.000 rs9562501 chr13:44205683 C/T cg19169023 chr15:41853346 TYRO3 -0.45 -7.71 -0.39 1.48e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg05623727 chr3:50126028 RBM5 0.33 6.04 0.31 4e-9 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.909 rs7681214 chr4:120385320 C/A cg24375607 chr4:120327624 NA 0.79 11.67 0.54 1.27e-26 Corneal astigmatism; LUSC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.13 0.45 6.62e-18 Height; LUSC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg02034447 chr16:89574710 SPG7 0.43 6.44 0.33 4.25e-10 Multiple myeloma (IgH translocation); LUSC cis rs1577917 0.566 rs2842611 chr6:86302034 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.48 -7.46 -0.38 7.67e-13 Response to antipsychotic treatment; LUSC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg08109568 chr15:31115862 NA -0.75 -10.86 -0.51 1.02e-23 Huntington's disease progression; LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg20607798 chr8:58055168 NA 0.49 5.9 0.31 8.7e-9 Developmental language disorder (linguistic errors); LUSC cis rs3020736 0.500 rs5996109 chr22:42493098 A/G cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg26202797 chr2:240005956 HDAC4 -0.4 -6.0 -0.31 5.22e-9 Thyroid stimulating hormone; LUSC cis rs2721195 1.000 rs1871541 chr8:145681713 G/T cg17328964 chr8:145687451 CYHR1 0.67 11.49 0.53 5.85e-26 Age at first birth; LUSC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg00149659 chr3:10157352 C3orf10 0.61 8.75 0.43 1.07e-16 Alzheimer's disease; LUSC cis rs2625529 0.938 rs8747 chr15:72115541 C/A cg16672083 chr15:72433130 SENP8 -0.49 -6.91 -0.35 2.39e-11 Red blood cell count; LUSC cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC cis rs2197308 0.765 rs117216293 chr12:37882982 T/C cg26384229 chr12:38710491 ALG10B -0.82 -13.77 -0.6 1.83e-34 Morning vs. evening chronotype; LUSC cis rs3806843 0.520 rs246051 chr5:140326464 G/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs80282103 0.764 rs7093915 chr10:1107341 A/G cg08668510 chr10:1095578 IDI1 -0.7 -6.39 -0.33 5.68e-10 Glomerular filtration rate (creatinine); LUSC cis rs308403 0.568 rs309344 chr4:123644812 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.82 10.85 0.51 1.06e-23 Blood protein levels; LUSC cis rs9790314 1.000 rs336589 chr3:161080358 C/T cg04691961 chr3:161091175 C3orf57 -0.36 -6.22 -0.32 1.51e-9 Morning vs. evening chronotype; LUSC cis rs2050392 0.517 rs602097 chr10:30747546 C/T cg25182066 chr10:30743637 MAP3K8 -0.47 -6.65 -0.34 1.22e-10 Inflammatory bowel disease; LUSC cis rs9790314 0.695 rs7637086 chr3:160836822 T/C cg03342759 chr3:160939853 NMD3 -0.41 -6.76 -0.35 6.14e-11 Morning vs. evening chronotype; LUSC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg03213289 chr20:61660250 NA 0.67 13.61 0.6 7.23e-34 Prostate cancer (SNP x SNP interaction); LUSC cis rs3806843 0.766 rs6848 chr5:140086062 A/T cg19875535 chr5:140030758 IK -0.5 -8.41 -0.42 1.23e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs763121 0.925 rs4821797 chr22:39016182 T/C cg06544989 chr22:39130855 UNC84B 0.37 6.74 0.35 6.93e-11 Menopause (age at onset); LUSC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg07395648 chr5:131743802 NA 0.44 7.04 0.36 1.07e-11 Breast cancer;Mosquito bite size; LUSC cis rs56399783 0.901 rs73049341 chr7:2812255 G/C cg19731401 chr7:2775893 GNA12 0.6 8.06 0.4 1.37e-14 Childhood ear infection; LUSC cis rs34779708 0.931 rs68039650 chr10:35385499 C/A cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9527 0.590 rs11191578 chr10:104902337 A/T cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs12908161 0.960 rs11633450 chr15:85307287 C/T cg12863693 chr15:85201151 NMB 0.38 7.66 0.39 2.08e-13 Schizophrenia; LUSC cis rs1507153 0.551 rs236859 chr6:79333116 G/A cg05283184 chr6:79620031 NA 0.38 6.97 0.36 1.7e-11 Sjögren's syndrome; LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 6.86 0.35 3.28e-11 Bipolar disorder; LUSC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.7 -10.72 -0.51 2.99e-23 Platelet count; LUSC cis rs11608355 0.545 rs918107 chr12:109904198 C/T cg05360138 chr12:110035743 NA -0.86 -11.03 -0.52 2.5e-24 Neuroticism; LUSC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg06637938 chr14:75390232 RPS6KL1 -0.45 -6.49 -0.33 3.05e-10 Height; LUSC cis rs1729951 0.575 rs35289288 chr3:136680568 C/T cg21827317 chr3:136751795 NA 0.39 6.91 0.35 2.41e-11 Neuroticism; LUSC trans rs6499188 0.571 rs1645975 chr16:68564448 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.79e-21 Obesity-related traits; LUSC cis rs6940638 0.688 rs9461335 chr6:27138529 C/A cg12826209 chr6:26865740 GUSBL1 0.52 7.52 0.38 5.08e-13 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg21862992 chr11:68658383 NA 0.5 7.9 0.4 3.94e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs208520 0.837 rs208488 chr6:66926902 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -13.91 -0.61 5.22e-35 Exhaled nitric oxide output; LUSC trans rs7937682 0.921 rs1944119 chr11:111436387 A/G cg18187862 chr3:45730750 SACM1L -0.52 -6.37 -0.33 6.34e-10 Primary sclerosing cholangitis; LUSC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11890956 chr21:40555474 PSMG1 1.0 18.51 0.71 3.77e-53 Cognitive function; LUSC cis rs7264396 0.887 rs11698935 chr20:34075015 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.57 -0.34 1.89e-10 Total cholesterol levels; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg06145435 chr7:1022769 CYP2W1 0.27 5.68 0.3 3.01e-8 Longevity;Endometriosis; LUSC cis rs7267979 1.000 rs6050609 chr20:25411751 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs4596713 0.538 rs7048094 chr9:71745660 G/C cg25283916 chr1:242222868 NA -0.29 -6.04 -0.31 4.19e-9 Headache; LUSC cis rs7582720 1.000 rs114393235 chr2:203795987 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg23131131 chr22:24373011 LOC391322 -0.43 -6.12 -0.32 2.56e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1018836 0.608 rs2142146 chr8:91464808 T/C cg16814680 chr8:91681699 NA -0.54 -7.95 -0.4 2.97e-14 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26094983 chr17:65242096 HELZ -0.41 -6.18 -0.32 1.84e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs72960926 0.744 rs11757177 chr6:74871785 C/A cg03266952 chr6:74778945 NA -0.79 -6.39 -0.33 5.64e-10 Metabolite levels (MHPG); LUSC cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg13010199 chr12:38710504 ALG10B 0.69 11.42 0.53 1.02e-25 Heart rate; LUSC cis rs9527 0.590 rs2148198 chr10:104915310 A/G cg08330031 chr10:104623503 C10orf32 -0.33 -5.88 -0.31 9.79e-9 Arsenic metabolism; LUSC cis rs3820928 0.904 rs1835159 chr2:227764057 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.8 -0.39 8.21e-14 Pulmonary function; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg18538332 chr22:24372958 LOC391322 0.46 8.24 0.41 3.84e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs911555 0.755 rs12432803 chr14:103930032 C/T cg12935359 chr14:103987150 CKB 0.66 10.71 0.51 3.27e-23 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.596 rs2494693 chr6:26619226 T/C cg11502198 chr6:26597334 ABT1 0.7 11.83 0.54 3.39e-27 Intelligence (multi-trait analysis); LUSC cis rs2180341 0.538 rs11556354 chr6:127664661 G/A cg27446573 chr6:127587934 RNF146 0.48 7.5 0.38 5.76e-13 Breast cancer; LUSC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg04450456 chr4:17643702 FAM184B 0.37 6.34 0.33 7.37e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6964587 0.967 rs28594877 chr7:91644070 C/T cg17063962 chr7:91808500 NA 0.57 9.07 0.44 1.02e-17 Breast cancer; LUSC cis rs6942756 0.806 rs1880854 chr7:128949748 G/T cg02491457 chr7:128862824 NA 0.51 7.69 0.39 1.63e-13 White matter hyperintensity burden; LUSC cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg22676075 chr6:135203613 NA -0.56 -9.08 -0.45 9.35e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs1832871 0.672 rs12529235 chr6:158766950 A/G cg07165851 chr6:158734300 TULP4 0.46 6.95 0.36 1.94e-11 Height; LUSC cis rs4853525 0.859 rs1882397 chr2:191720132 A/C cg11845111 chr2:191398756 TMEM194B -0.42 -6.18 -0.32 1.91e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs6752107 1.000 rs2289472 chr2:234182240 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.78 0.54 4.92e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg24675056 chr1:15929824 NA 0.45 7.85 0.39 5.81e-14 Systolic blood pressure; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15891644 chr15:40751006 BAHD1 -0.42 -6.23 -0.32 1.42e-9 Asthma; LUSC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg20891283 chr12:69753455 YEATS4 0.66 10.48 0.5 2.16e-22 Blood protein levels; LUSC cis rs7927771 0.507 rs10838754 chr11:47758532 A/C cg20307385 chr11:47447363 PSMC3 0.44 6.35 0.33 7.06e-10 Subjective well-being; LUSC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg04315214 chr1:2043799 PRKCZ -0.4 -8.01 -0.4 1.89e-14 Height; LUSC cis rs7799006 0.757 rs2398668 chr7:2298227 A/G cg12823233 chr7:2316876 SNX8 0.43 7.48 0.38 6.8e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs1300170 0.685 rs1733504 chr3:71372797 C/T cg06537372 chr1:244923979 NA 0.52 6.74 0.35 7.05e-11 Myringotomy; LUSC cis rs6500395 0.926 rs9929569 chr16:48677584 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.4 0.33 5.11e-10 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs208520 0.909 rs55813840 chr6:67012508 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 8.76 0.43 9.74e-17 Exhaled nitric oxide output; LUSC cis rs2115630 0.936 rs8033459 chr15:85253258 C/T cg09876464 chr15:85330779 ZNF592 0.35 6.42 0.33 4.81e-10 P wave terminal force; LUSC trans rs9929218 1.000 rs9282650 chr16:68809640 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.72 -0.54 8.62e-27 Colorectal cancer; LUSC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg20476274 chr7:133979776 SLC35B4 0.83 15.07 0.64 1.56e-39 Mean platelet volume; LUSC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg05110241 chr16:68378359 PRMT7 -0.57 -6.61 -0.34 1.52e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1975974 1.000 rs4889732 chr17:21721443 T/C cg18423549 chr17:21743878 NA -0.5 -7.62 -0.38 2.6e-13 Psoriasis; LUSC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg09365446 chr1:150670422 GOLPH3L -0.43 -6.42 -0.33 4.69e-10 Tonsillectomy; LUSC cis rs12101261 0.560 rs1035144 chr14:81445121 C/T cg06600135 chr14:81408086 NA 0.47 7.23 0.37 3.22e-12 Graves' disease; LUSC cis rs9527 0.590 rs7910900 chr10:104829898 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.71 -0.34 8.2e-11 Arsenic metabolism; LUSC cis rs911119 1.000 rs34897231 chr20:23620268 A/G cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC cis rs7267979 0.873 rs6115093 chr20:25210730 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.77 15.37 0.64 1.03e-40 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6840360 0.615 rs4696266 chr4:152463421 A/G cg22705602 chr4:152727874 NA -0.32 -6.49 -0.33 3.05e-10 Intelligence (multi-trait analysis); LUSC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg20302533 chr7:39170763 POU6F2 0.55 9.24 0.45 2.87e-18 IgG glycosylation; LUSC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg16797656 chr11:68205561 LRP5 0.39 7.12 0.36 6.6e-12 Total body bone mineral density; LUSC cis rs6815814 0.950 rs56289835 chr4:38811845 G/C cg02016764 chr4:38805732 TLR1 -0.54 -5.74 -0.3 2.17e-8 Breast cancer; LUSC cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs983392 0.679 rs1026252 chr11:60030559 C/T cg24026212 chr11:59952134 MS4A6A 0.36 6.15 0.32 2.27e-9 Alzheimer's disease (late onset); LUSC cis rs6121246 0.909 rs6119720 chr20:30347568 T/G cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC cis rs950027 0.620 rs1145077 chr15:45683795 A/C cg14582100 chr15:45693742 SPATA5L1 -0.43 -8.15 -0.41 7.45e-15 Response to fenofibrate (adiponectin levels); LUSC trans rs561341 0.883 rs2074102 chr17:30228884 G/A cg20587970 chr11:113659929 NA -1.1 -13.4 -0.59 4.63e-33 Hip circumference adjusted for BMI; LUSC cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg26384229 chr12:38710491 ALG10B -0.83 -15.55 -0.65 2.11e-41 Heart rate; LUSC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg01947301 chr1:205718900 NUCKS1 -0.46 -6.53 -0.34 2.46e-10 Cognitive function;Information processing speed; LUSC cis rs9815354 0.812 rs17280952 chr3:41810834 T/C cg03022575 chr3:42003672 ULK4 0.85 8.65 0.43 2.23e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg20684491 chr1:25596433 NA 0.38 5.88 0.31 9.87e-9 Erythrocyte sedimentation rate; LUSC cis rs11018904 0.861 rs12786959 chr11:89943676 A/T cg26834418 chr11:89957033 CHORDC1 -0.52 -6.21 -0.32 1.61e-9 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs6076339 chr20:25348712 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -19.59 -0.73 1.96e-57 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg09699651 chr6:150184138 LRP11 0.37 5.65 0.3 3.47e-8 Lung cancer; LUSC cis rs11785400 0.793 rs3735993 chr8:143741170 G/A cg24634471 chr8:143751801 JRK 0.51 7.18 0.37 4.47e-12 Schizophrenia; LUSC trans rs11039798 0.764 rs12418936 chr11:48986418 T/C cg03929089 chr4:120376271 NA 0.73 6.23 0.32 1.39e-9 Axial length; LUSC cis rs709400 0.663 rs1028613 chr14:103888324 G/A cg10523860 chr14:103875565 MARK3 -0.39 -6.03 -0.31 4.31e-9 Body mass index; LUSC cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg15073853 chr19:18549131 ISYNA1 -0.33 -6.06 -0.31 3.76e-9 Breast cancer; LUSC cis rs62400317 0.826 rs11970412 chr6:45037516 C/T cg18551225 chr6:44695536 NA -0.42 -6.89 -0.35 2.72e-11 Total body bone mineral density; LUSC cis rs7914558 0.902 rs3736922 chr10:104850632 A/G cg05855489 chr10:104503620 C10orf26 -0.53 -8.18 -0.41 6.09e-15 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg03579872 chr1:53393473 SCP2 -0.39 -5.74 -0.3 2.09e-8 Monocyte count; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg11829371 chr17:981724 ABR -0.37 -6.13 -0.32 2.51e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1322512 0.876 rs1727051 chr6:152944891 A/C cg27316956 chr6:152958899 SYNE1 -0.34 -5.74 -0.3 2.17e-8 Tonometry; LUSC cis rs3806843 1.000 rs10477034 chr5:140169730 A/G cg26395211 chr5:140044315 WDR55 -0.37 -5.7 -0.3 2.62e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9309473 0.847 rs4547554 chr2:73867862 G/C cg20560298 chr2:73613845 ALMS1 -0.42 -5.97 -0.31 6.21e-9 Metabolite levels; LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.94 -0.58 2.6e-31 Platelet count; LUSC cis rs8141529 0.764 rs5762824 chr22:29222930 C/T cg15103426 chr22:29168792 CCDC117 0.6 8.35 0.42 1.89e-15 Lymphocyte counts; LUSC cis rs9811920 0.965 rs6767441 chr3:99863183 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 6.77 0.35 5.79e-11 Axial length; LUSC cis rs11649653 0.502 rs4889490 chr16:30823047 A/C cg02466173 chr16:30829666 NA -0.47 -9.2 -0.45 4.1e-18 Triglycerides; LUSC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg21782813 chr7:2030301 MAD1L1 0.45 7.49 0.38 6.06e-13 Schizophrenia; LUSC cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg14530993 chr4:882597 GAK -0.65 -7.16 -0.36 5.04e-12 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg04455712 chr21:45112962 RRP1B 0.43 8.14 0.41 7.98e-15 Mean corpuscular volume; LUSC cis rs7712401 0.715 rs407392 chr5:122360994 C/T cg19077854 chr5:122220652 SNX24 -0.42 -9.04 -0.44 1.35e-17 Mean platelet volume; LUSC cis rs2777491 0.957 rs7181911 chr15:41674060 T/C cg18705301 chr15:41695430 NDUFAF1 -0.76 -14.69 -0.63 5.06e-38 Ulcerative colitis; LUSC cis rs6964587 1.000 rs12536529 chr7:91684086 C/T cg01689657 chr7:91764605 CYP51A1 -0.32 -5.69 -0.3 2.77e-8 Breast cancer; LUSC cis rs9420 0.922 rs35808061 chr11:57547000 T/C cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.22e-10 Schizophrenia; LUSC trans rs9393777 0.841 rs13191474 chr6:27413345 C/T cg01620082 chr3:125678407 NA -0.81 -7.34 -0.37 1.6e-12 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs1475911 1.000 rs17114359 chr21:43510437 A/C cg03240473 chr21:43526662 UMODL1;C21orf128 -0.4 -6.14 -0.32 2.34e-9 IgG glycosylation; LUSC cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg18404041 chr3:52824283 ITIH1 -0.57 -9.57 -0.46 2.56e-19 Schizophrenia; LUSC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg05535760 chr7:792225 HEATR2 -0.77 -8.28 -0.41 2.95e-15 Cerebrospinal P-tau181p levels; LUSC cis rs12368653 0.584 rs7295422 chr12:58099736 G/A cg12615879 chr12:58013172 SLC26A10 0.36 8.16 0.41 7.09e-15 Multiple sclerosis; LUSC cis rs1506636 1.000 rs689341 chr7:123403974 C/A cg03229431 chr7:123269106 ASB15 0.65 10.7 0.51 3.69e-23 Plateletcrit;Platelet count; LUSC trans rs3857536 0.813 rs7766786 chr6:66932889 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.37 0.37 1.38e-12 Bipolar disorder; LUSC cis rs7572733 0.534 rs4550664 chr2:198691405 C/T cg00792783 chr2:198669748 PLCL1 0.44 5.83 0.3 1.28e-8 Dermatomyositis; LUSC trans rs208520 0.754 rs7753158 chr6:66875633 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -15.1 -0.64 1.28e-39 Exhaled nitric oxide output; LUSC trans rs12310956 0.532 rs11052952 chr12:33988048 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.42 0.42 1.12e-15 Morning vs. evening chronotype; LUSC cis rs3741151 1.000 rs79038783 chr11:73038746 C/G cg17517138 chr11:73019481 ARHGEF17 1.14 9.69 0.47 9.65e-20 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg14416269 chr4:6271139 WFS1 0.54 11.41 0.53 1.08e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg13319975 chr6:146136371 FBXO30 0.48 7.25 0.37 2.96e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.0 0.4 2.1e-14 Bipolar disorder; LUSC trans rs61931739 0.534 rs10844767 chr12:34152368 C/G cg26384229 chr12:38710491 ALG10B 0.73 11.91 0.55 1.75e-27 Morning vs. evening chronotype; LUSC cis rs6598955 0.724 rs884533 chr1:26585657 G/T cg00852783 chr1:26633632 UBXN11 0.49 8.71 0.43 1.45e-16 Obesity-related traits; LUSC cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg22676075 chr6:135203613 NA 0.56 8.89 0.44 3.95e-17 Red blood cell count; LUSC cis rs4803468 1.000 rs4803469 chr19:41922775 A/C cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.41 5.66 0.3 3.22e-8 Height; LUSC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.01 0.48 8.39e-21 Electroencephalogram traits; LUSC trans rs12210905 0.925 rs12212317 chr6:26986553 G/A cg11837749 chr1:55047332 ACOT11 0.55 5.96 0.31 6.41e-9 Hip circumference adjusted for BMI; LUSC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg11247378 chr22:39784982 NA -0.65 -12.86 -0.58 4.87e-31 Intelligence (multi-trait analysis); LUSC cis rs12545109 0.837 rs1437277 chr8:57356734 T/C cg09654669 chr8:57350985 NA -0.56 -7.48 -0.38 6.83e-13 Obesity-related traits; LUSC cis rs713587 0.571 rs546217 chr2:25311537 A/C cg01884057 chr2:25150051 NA -0.27 -5.84 -0.3 1.25e-8 Body mass index in non-asthmatics; LUSC cis rs644799 0.544 rs499637 chr11:95569183 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.27 0.45 2.37e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs13006833 0.739 rs291470 chr2:191189558 T/A cg21644426 chr2:191273491 MFSD6 0.44 6.36 0.33 6.81e-10 Urinary metabolites; LUSC cis rs2637266 0.783 rs846633 chr10:78535744 A/C cg18941641 chr10:78392320 NA -0.39 -7.0 -0.36 1.37e-11 Pulmonary function; LUSC cis rs61931739 0.517 rs2636074 chr12:34064056 C/T cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.09e-15 Morning vs. evening chronotype; LUSC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg04511125 chr2:88470314 THNSL2 0.96 9.39 0.46 9.75e-19 Plasma clusterin levels; LUSC cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.0 14.25 0.61 2.51e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg00166722 chr3:10149974 C3orf24 0.6 7.97 0.4 2.62e-14 Alzheimer's disease; LUSC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg11764359 chr7:65958608 NA 0.63 9.45 0.46 6.08e-19 Calcium levels; LUSC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.74e-12 Resting heart rate; LUSC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC trans rs7746199 0.736 rs72845070 chr6:27668300 A/C cg06606381 chr12:133084897 FBRSL1 -1.0 -8.78 -0.43 8.49e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg08847533 chr14:75593920 NEK9 -0.79 -14.28 -0.62 1.99e-36 Height; LUSC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg22782873 chr19:19639568 YJEFN3 -0.49 -6.12 -0.32 2.56e-9 Bipolar disorder; LUSC cis rs1728785 0.818 rs1814299 chr16:68581332 G/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC trans rs8072100 0.701 rs8075566 chr17:45771037 G/A cg03886242 chr7:26192032 NFE2L3 -0.4 -6.21 -0.32 1.58e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs73198271 0.740 rs28402110 chr8:8647249 C/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.2 -0.32 1.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7582180 0.903 rs2309818 chr2:100898634 G/T cg08017756 chr2:100939284 LONRF2 -0.37 -6.23 -0.32 1.41e-9 Intelligence (multi-trait analysis); LUSC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.5 -7.06 -0.36 9.62e-12 Tuberculosis; LUSC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg13206674 chr6:150067644 NUP43 0.6 9.55 0.46 2.91e-19 Lung cancer; LUSC cis rs2625529 0.652 rs2034879 chr15:72429989 A/G cg16672083 chr15:72433130 SENP8 -0.5 -8.15 -0.41 7.52e-15 Red blood cell count; LUSC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg05535760 chr7:792225 HEATR2 0.82 9.72 0.47 7.74e-20 Cerebrospinal P-tau181p levels; LUSC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg02569458 chr12:86230093 RASSF9 0.52 8.4 0.42 1.31e-15 Major depressive disorder; LUSC cis rs6732160 0.691 rs1960233 chr2:73421378 A/G cg24220031 chr2:73402428 NA -0.23 -5.76 -0.3 1.9e-8 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.720 rs6704498 chr1:152964740 C/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.64 -0.39 2.34e-13 Inflammatory skin disease; LUSC cis rs9549260 0.755 rs7993233 chr13:41219434 T/A cg21288729 chr13:41239152 FOXO1 0.65 10.06 0.48 5.76e-21 Red blood cell count; LUSC cis rs7659604 0.521 rs4833234 chr4:122694799 T/C cg06713675 chr4:122721982 EXOSC9 0.38 6.02 0.31 4.56e-9 Type 2 diabetes; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg08721076 chr2:172967670 DLX2 0.43 6.35 0.33 7.08e-10 Asthma; LUSC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg06481639 chr22:41940642 POLR3H 0.48 5.8 0.3 1.57e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7267979 0.903 rs1118963 chr20:25247449 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.78 16.08 0.66 1.78e-43 Liver enzyme levels (alkaline phosphatase); LUSC cis rs796364 0.901 rs13030683 chr2:201061535 C/T cg23649088 chr2:200775458 C2orf69 0.51 6.94 0.35 2.05e-11 Schizophrenia; LUSC trans rs2370759 0.891 rs11592754 chr10:32619572 A/C cg07829597 chr10:77161705 C10orf41;ZNF503 0.67 6.38 0.33 6.05e-10 Sexual dysfunction (female); LUSC cis rs4363385 0.747 rs4845332 chr1:152982632 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.33e-13 Inflammatory skin disease; LUSC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg22433210 chr17:43662623 NA -0.73 -10.61 -0.5 7.63e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg10360139 chr7:1886902 MAD1L1 -0.46 -7.07 -0.36 9.23e-12 Bipolar disorder and schizophrenia; LUSC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.93 -0.35 2.23e-11 Lung cancer; LUSC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg00908189 chr16:619842 PIGQ 0.67 10.37 0.49 4.85e-22 Height; LUSC cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg24642439 chr20:33292090 TP53INP2 0.48 7.23 0.37 3.41e-12 Glomerular filtration rate (creatinine); LUSC cis rs2227564 0.620 rs12783161 chr10:75572201 G/C cg23231163 chr10:75533350 FUT11 -0.45 -6.59 -0.34 1.69e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9287719 0.967 rs6751398 chr2:10738972 T/C cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs9650657 0.506 rs7823296 chr8:10778546 A/G cg21775007 chr8:11205619 TDH -0.46 -6.3 -0.33 9.18e-10 Neuroticism; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.95 -12.54 -0.57 7.84e-30 Platelet count; LUSC cis rs9486719 0.895 rs11152960 chr6:96900398 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs1348850 0.597 rs13014512 chr2:178470851 T/A cg27490568 chr2:178487706 NA 0.42 5.87 0.31 1.07e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.45 7.13 0.36 6.09e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11864453 0.786 rs1050362 chr16:72130815 C/A cg16558253 chr16:72132732 DHX38 -0.41 -6.32 -0.33 8.5e-10 Fibrinogen levels; LUSC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.9 -0.35 2.69e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg11764359 chr7:65958608 NA -0.69 -10.59 -0.5 8.56e-23 Aortic root size; LUSC cis rs7617773 0.780 rs4479622 chr3:48338173 C/T cg20734569 chr3:48348370 SPINK8 -0.46 -7.81 -0.39 7.43e-14 Coronary artery disease; LUSC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg08677398 chr8:58056175 NA 0.58 5.8 0.3 1.52e-8 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg04944784 chr2:26401820 FAM59B -0.7 -9.8 -0.47 4.26e-20 Gut microbiome composition (summer); LUSC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg10802521 chr3:52805072 NEK4 -0.57 -9.23 -0.45 3.23e-18 Bipolar disorder; LUSC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.69e-14 Systolic blood pressure; LUSC cis rs8062405 1.000 rs7498555 chr16:28893571 T/C cg09754948 chr16:28834200 ATXN2L 0.43 6.07 0.32 3.5e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7512552 0.839 rs12042229 chr1:150447398 A/G cg15654264 chr1:150340011 RPRD2 0.65 10.8 0.51 1.56e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg01802117 chr1:53393560 SCP2 -0.37 -6.13 -0.32 2.52e-9 Monocyte count; LUSC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg16624210 chr5:671434 TPPP 0.44 5.7 0.3 2.64e-8 Lung disease severity in cystic fibrosis; LUSC cis rs4629180 0.917 rs7560926 chr2:102125098 C/A cg04415270 chr2:102091202 RFX8 0.56 8.93 0.44 2.81e-17 Chronic rhinosinusitis with nasal polyps; LUSC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg00944433 chr1:107599041 PRMT6 0.38 6.96 0.36 1.79e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs644799 0.710 rs473852 chr11:95568757 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.82 13.57 0.6 1.05e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs240764 0.645 rs239208 chr6:101139285 G/A cg09795085 chr6:101329169 ASCC3 0.41 5.93 0.31 7.56e-9 Neuroticism; LUSC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.6 0.38 3.04e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg23791538 chr6:167370224 RNASET2 -0.37 -5.85 -0.3 1.17e-8 Crohn's disease; LUSC cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg23029597 chr12:123009494 RSRC2 -0.7 -9.79 -0.47 4.7e-20 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13093793 chr14:35099518 SNX6 0.41 6.21 0.32 1.59e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3760982 1.000 rs12460161 chr19:44293986 C/A cg11993925 chr19:44307056 LYPD5 0.28 6.04 0.31 4.16e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs7123876 0.587 rs184654 chr11:72364405 C/G cg04827223 chr11:72435913 ARAP1 -0.49 -6.08 -0.32 3.23e-9 Body mass index; LUSC cis rs2652834 0.851 rs4551986 chr15:63424400 T/G cg05507819 chr15:63340323 TPM1 0.47 6.03 0.31 4.35e-9 HDL cholesterol; LUSC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg27170947 chr2:26402098 FAM59B 0.59 8.15 0.41 7.43e-15 Gut microbiome composition (summer); LUSC cis rs13385 0.769 rs6872766 chr5:139595614 A/C cg26211634 chr5:139558579 C5orf32 0.45 6.73 0.35 7.44e-11 Atrial fibrillation; LUSC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg12463550 chr7:65579703 CRCP 0.45 6.58 0.34 1.79e-10 Aortic root size; LUSC cis rs4654899 0.802 rs115818417 chr1:21200411 C/T cg02927042 chr1:21476669 EIF4G3 -0.38 -5.91 -0.31 8.49e-9 Superior frontal gyrus grey matter volume; LUSC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg19748678 chr4:122722346 EXOSC9 0.74 11.18 0.52 7.35e-25 Type 2 diabetes; LUSC cis rs4730250 0.595 rs7789500 chr7:106915723 A/C cg02696742 chr7:106810147 HBP1 -0.54 -7.33 -0.37 1.8e-12 Osteoarthritis; LUSC trans rs2229238 0.911 rs77184252 chr1:154492533 A/G cg25273160 chr11:56955011 LRRC55 0.31 5.96 0.31 6.37e-9 Coronary heart disease; LUSC cis rs2011503 0.782 rs35545554 chr19:19715613 A/G cg11244672 chr19:19639970 YJEFN3 0.47 6.08 0.32 3.23e-9 Bipolar disorder; LUSC cis rs3007168 1.000 rs2999363 chr14:51605141 A/G cg23942311 chr14:51606299 NA 0.37 6.02 0.31 4.5e-9 Cancer; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg01802117 chr1:53393560 SCP2 -0.38 -6.0 -0.31 5.06e-9 Monocyte count; LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.33 0.37 1.8e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.84 -0.3 1.27e-8 Alzheimer's disease (late onset); LUSC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21659725 chr3:3221576 CRBN 0.89 18.14 0.7 1.17e-51 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg18512352 chr11:47633146 NA -0.47 -9.32 -0.45 1.62e-18 Subjective well-being; LUSC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg06481639 chr22:41940642 POLR3H -0.51 -5.76 -0.3 1.86e-8 Vitiligo; LUSC cis rs7166081 0.738 rs28399271 chr15:67710011 G/A cg05925327 chr15:68127851 NA -0.39 -6.01 -0.31 4.97e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs12541335 0.603 rs9792127 chr8:22180334 G/A cg27266060 chr8:22091797 NA 0.42 7.7 0.39 1.61e-13 Hypertriglyceridemia; LUSC cis rs977987 0.843 rs10871312 chr16:75486202 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.96 -0.36 1.79e-11 Dupuytren's disease; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg00166722 chr3:10149974 C3orf24 0.61 8.38 0.42 1.46e-15 Alzheimer's disease; LUSC cis rs4654899 0.733 rs10916907 chr1:21261088 A/C cg01072550 chr1:21505969 NA -0.53 -7.99 -0.4 2.25e-14 Superior frontal gyrus grey matter volume; LUSC cis rs2346177 0.554 rs34854267 chr2:46708542 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.6 -9.47 -0.46 5.4e-19 HDL cholesterol; LUSC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg05717871 chr11:638507 DRD4 -0.34 -5.9 -0.31 8.74e-9 Systemic lupus erythematosus; LUSC cis rs1348850 0.914 rs4341974 chr2:178324879 A/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.12 0.36 6.81e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg14004847 chr7:1930337 MAD1L1 -0.53 -8.07 -0.4 1.31e-14 Bipolar disorder and schizophrenia; LUSC cis rs9549367 0.789 rs34448227 chr13:113884754 A/C cg00898013 chr13:113819073 PROZ -0.57 -8.22 -0.41 4.55e-15 Platelet distribution width; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg22530072 chr19:1546320 NA 0.44 6.18 0.32 1.91e-9 Eotaxin levels; LUSC cis rs4363385 0.530 rs11205181 chr1:153045728 C/T cg25856811 chr1:152973957 SPRR3 -0.39 -6.5 -0.34 2.96e-10 Inflammatory skin disease; LUSC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg03354898 chr7:1950403 MAD1L1 0.33 6.33 0.33 7.74e-10 Schizophrenia; LUSC cis rs4319547 0.741 rs4758644 chr12:122943915 A/C cg23029597 chr12:123009494 RSRC2 -0.62 -8.2 -0.41 5.16e-15 Body mass index; LUSC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg14416269 chr4:6271139 WFS1 -0.52 -11.07 -0.52 1.75e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11155671 0.530 rs4869763 chr6:150211684 T/C cg09699651 chr6:150184138 LRP11 0.45 7.19 0.37 4.17e-12 Testicular germ cell tumor; LUSC cis rs6545883 0.929 rs6707830 chr2:61749472 G/A cg15711740 chr2:61764176 XPO1 -0.48 -7.59 -0.38 3.23e-13 Tuberculosis; LUSC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg08470875 chr2:26401718 FAM59B 0.72 9.46 0.46 5.58e-19 Gut microbiome composition (summer); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00628130 chr8:95908808 CCNE2 -0.35 -6.03 -0.31 4.41e-9 Electrocardiographic conduction measures; LUSC cis rs478304 0.654 rs7115734 chr11:65458964 G/A cg05805236 chr11:65401703 PCNXL3 -0.65 -10.64 -0.5 5.92e-23 Acne (severe); LUSC cis rs11098499 0.604 rs2389887 chr4:120570644 T/C cg24375607 chr4:120327624 NA 0.71 10.36 0.49 5.29e-22 Corneal astigmatism; LUSC cis rs7267979 1.000 rs7268053 chr20:25328286 A/T cg08601574 chr20:25228251 PYGB -0.42 -6.35 -0.33 7.19e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1355223 0.573 rs1361646 chr11:34746360 G/A cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.86 -0.31 1.14e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg11494091 chr17:61959527 GH2 0.63 13.38 0.59 5.41e-33 Prudent dietary pattern; LUSC cis rs6542838 0.673 rs13005148 chr2:99467538 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.21 -0.32 1.53e-9 Fear of minor pain; LUSC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs34779708 0.931 rs17582416 chr10:35287650 A/C cg03585969 chr10:35415529 CREM 0.54 7.89 0.4 4.28e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg01851573 chr8:8652454 MFHAS1 -0.35 -6.11 -0.32 2.85e-9 Mood instability; LUSC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg25767906 chr1:53392781 SCP2 -0.51 -9.28 -0.45 2.23e-18 Monocyte count; LUSC cis rs826838 1.000 rs860400 chr12:39081279 A/G cg13010199 chr12:38710504 ALG10B -0.63 -10.54 -0.5 1.26e-22 Heart rate; LUSC cis rs1957429 0.808 rs1951492 chr14:65346895 G/A cg23373153 chr14:65346875 NA 1.11 13.01 0.58 1.35e-31 Pediatric areal bone mineral density (radius); LUSC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg09323728 chr8:95962352 TP53INP1 -0.41 -8.71 -0.43 1.43e-16 Type 2 diabetes; LUSC cis rs727505 1.000 rs6943653 chr7:124512249 G/A cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg12311346 chr5:56204834 C5orf35 -0.93 -12.73 -0.57 1.55e-30 Initial pursuit acceleration; LUSC cis rs765787 0.530 rs4774542 chr15:45526026 A/C cg25801113 chr15:45476975 SHF -0.33 -6.7 -0.34 8.9e-11 Uric acid levels; LUSC cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg22676075 chr6:135203613 NA 0.58 9.18 0.45 4.49e-18 Red blood cell count; LUSC cis rs1267303 0.642 rs1267301 chr1:46992853 C/G cg25110126 chr1:46999211 NA -0.76 -10.42 -0.5 3.48e-22 Monobrow; LUSC cis rs4917300 0.967 rs2201177 chr8:143119176 T/C cg25363559 chr8:143086065 NA -0.28 -5.98 -0.31 5.64e-9 Amyotrophic lateral sclerosis; LUSC cis rs11098499 0.863 rs1480940 chr4:120457682 T/C cg09307838 chr4:120376055 NA 0.73 10.34 0.49 6.36e-22 Corneal astigmatism; LUSC cis rs9394152 0.810 rs9380364 chr6:33471721 T/C cg13560919 chr6:33536144 NA 0.6 10.63 0.5 6.18e-23 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs10504073 0.647 rs9643394 chr8:50014427 A/G cg00325661 chr8:49890786 NA 0.62 10.4 0.49 3.99e-22 Blood metabolite ratios; LUSC cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg07828340 chr4:882639 GAK 1.11 10.81 0.51 1.44e-23 Intelligence (multi-trait analysis); LUSC cis rs6960043 0.875 rs10249299 chr7:15054391 C/T cg19272540 chr7:15055459 NA 0.35 8.89 0.44 3.97e-17 Type 2 diabetes; LUSC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg02034447 chr16:89574710 SPG7 0.4 5.96 0.31 6.4e-9 Multiple myeloma (IgH translocation); LUSC cis rs9372253 0.967 rs9400379 chr6:110713783 A/G cg01119278 chr6:110721349 DDO -0.49 -8.79 -0.43 8.09e-17 Platelet distribution width; LUSC cis rs11871801 0.517 rs645692 chr17:40701073 C/T cg16308533 chr17:40838983 CNTNAP1 0.41 5.97 0.31 6.11e-9 Crohn's disease; LUSC cis rs983392 0.679 rs1530914 chr11:60028940 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.11 0.32 2.83e-9 Alzheimer's disease (late onset); LUSC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg12310025 chr6:25882481 NA 0.4 6.65 0.34 1.22e-10 Intelligence (multi-trait analysis); LUSC cis rs28595532 0.623 rs34958556 chr4:119222074 C/T cg21605333 chr4:119757512 SEC24D 0.8 6.67 0.34 1.04e-10 Cannabis dependence symptom count; LUSC cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg00012203 chr2:219082015 ARPC2 0.87 16.03 0.66 2.64e-43 Colorectal cancer; LUSC cis rs1107366 0.722 rs9862438 chr3:125910381 C/T cg01346077 chr3:125931526 NA 0.36 6.95 0.36 1.98e-11 Metabolite levels; LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg22920501 chr2:26401640 FAM59B 0.83 12.02 0.55 6.49e-28 Gut microbiome composition (summer); LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg13395646 chr4:1353034 KIAA1530 0.59 9.02 0.44 1.51e-17 Obesity-related traits; LUSC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.29e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7617480 0.648 rs6801211 chr3:48774420 C/G cg07636037 chr3:49044803 WDR6 0.93 13.08 0.58 7.68e-32 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11644478 chr21:40555479 PSMG1 0.9 16.3 0.67 2.25e-44 Cognitive function; LUSC cis rs2294693 0.945 rs9381023 chr6:40983281 C/T cg14769373 chr6:40998127 UNC5CL 0.54 7.71 0.39 1.44e-13 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg13319975 chr6:146136371 FBXO30 -0.47 -6.84 -0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23600533 chr11:64885249 ZNHIT2 0.7 6.0 0.31 5.04e-9 Cognitive performance; LUSC cis rs7582720 1.000 rs72936847 chr2:203774748 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.38 0.42 1.49e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10416265 0.503 rs1981818 chr19:33615122 C/T cg17764715 chr19:33622953 WDR88 -0.53 -7.8 -0.39 7.84e-14 Bone properties (heel); LUSC trans rs11098499 0.863 rs12508173 chr4:120318526 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.22 0.32 1.49e-9 Corneal astigmatism; LUSC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg14895029 chr7:2775587 GNA12 -0.41 -6.07 -0.32 3.46e-9 Height; LUSC cis rs6500395 0.788 rs12446280 chr16:48651171 G/T cg04672837 chr16:48644449 N4BP1 0.47 6.73 0.35 7.28e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1538970 1.000 rs1538970 chr1:45847562 G/A cg05343316 chr1:45956843 TESK2 0.59 8.0 0.4 2e-14 Platelet count; LUSC cis rs10754283 0.967 rs7546410 chr1:90109815 C/T cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9311676 0.632 rs6445978 chr3:58379586 T/A cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC cis rs12701220 0.689 rs6973645 chr7:1112246 C/T cg26769984 chr7:1090371 C7orf50 0.57 7.16 0.36 5.3e-12 Bronchopulmonary dysplasia; LUSC cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg04450456 chr4:17643702 FAM184B 0.38 6.28 0.33 1.03e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.84 0.51 1.21e-23 Heart rate; LUSC cis rs8072100 0.713 rs3871595 chr17:45511388 C/T cg08085267 chr17:45401833 C17orf57 -0.51 -7.3 -0.37 2.07e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg02487422 chr3:49467188 NICN1 -0.44 -7.16 -0.36 5.15e-12 Resting heart rate; LUSC cis rs7769051 0.522 rs6934155 chr6:133124021 C/T cg07930552 chr6:133119739 C6orf192 0.94 8.39 0.42 1.41e-15 Type 2 diabetes nephropathy; LUSC cis rs10484885 0.757 rs72912535 chr6:90159762 A/G cg13799429 chr6:90582589 CASP8AP2 -0.61 -5.67 -0.3 3.04e-8 QRS interval (sulfonylurea treatment interaction); LUSC trans rs2786098 0.616 rs10922251 chr1:197521810 C/G cg16005942 chr6:160526640 IGF2R 0.53 6.28 0.32 1.04e-9 Asthma; LUSC cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg03146154 chr1:46216737 IPP 0.54 7.73 0.39 1.27e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2282032 1.000 rs75816060 chr14:90759470 C/T cg11965331 chr8:7651924 NA 0.42 5.96 0.31 6.31e-9 Longevity; LUSC cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg07606381 chr6:8435919 SLC35B3 0.73 12.19 0.56 1.52e-28 Motion sickness; LUSC cis rs4240897 0.935 rs4846082 chr1:12042443 C/T cg13216073 chr1:12042593 MFN2 0.38 6.66 0.34 1.11e-10 Tuberculosis; LUSC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg13798780 chr7:105162888 PUS7 0.56 6.08 0.32 3.26e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6089584 0.893 rs2281735 chr20:60582540 T/A cg13770153 chr20:60521292 NA -0.63 -8.76 -0.43 9.88e-17 Body mass index; LUSC cis rs4776059 0.550 rs17651941 chr15:52948626 C/G cg22715398 chr15:52968154 KIAA1370 0.7 7.81 0.39 7.24e-14 Schizophrenia; LUSC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg12756686 chr19:29218302 NA 0.47 5.79 0.3 1.61e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg01475377 chr6:109611718 NA -0.4 -7.15 -0.36 5.47e-12 Reticulocyte fraction of red cells; LUSC cis rs6460942 0.915 rs7803051 chr7:12306904 A/T cg06484146 chr7:12443880 VWDE -0.49 -5.9 -0.31 8.72e-9 Coronary artery disease; LUSC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg23711669 chr6:146136114 FBXO30 -0.82 -14.69 -0.63 5.14e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg25767906 chr1:53392781 SCP2 0.48 8.69 0.43 1.67e-16 Monocyte count; LUSC cis rs6456156 0.565 rs6456153 chr6:167472167 T/C cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg23158103 chr7:148848205 ZNF398 -0.5 -8.39 -0.42 1.34e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg00933542 chr6:150070202 PCMT1 0.27 5.65 0.3 3.43e-8 Lung cancer; LUSC cis rs4776059 0.761 rs12594964 chr15:52900208 G/A cg24008177 chr15:52972085 KIAA1370 -0.34 -5.93 -0.31 7.39e-9 Schizophrenia; LUSC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg20476274 chr7:133979776 SLC35B4 0.87 17.01 0.68 3.4e-47 Mean platelet volume; LUSC cis rs2438150 1 rs2438150 chr5:122199196 C/T cg19077854 chr5:122220652 SNX24 0.36 8.34 0.42 2e-15 Plateletcrit; LUSC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.54 -0.38 4.54e-13 Height; LUSC cis rs1348850 0.526 rs6723063 chr2:178491398 C/T cg22681709 chr2:178499509 PDE11A -0.49 -6.33 -0.33 7.88e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11603020 0.950 rs28362947 chr11:57369008 C/G cg23127183 chr11:57508653 C11orf31 -0.46 -6.36 -0.33 6.65e-10 Blood protein levels; LUSC cis rs11098499 0.826 rs4472123 chr4:120236630 T/A cg09307838 chr4:120376055 NA 0.7 10.37 0.49 4.84e-22 Corneal astigmatism; LUSC cis rs7424096 0.582 rs12105781 chr2:37221567 T/C cg14987922 chr2:37194071 STRN 0.6 8.09 0.4 1.11e-14 High light scatter reticulocyte percentage of red cells; LUSC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.89 0.61 5.99e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7804356 1.000 rs6956088 chr7:26835727 T/A cg03456212 chr7:26904342 SKAP2 -0.55 -6.47 -0.33 3.53e-10 Type 1 diabetes; LUSC cis rs600231 0.542 rs11227196 chr11:65234922 G/A cg17120908 chr11:65337727 SSSCA1 -0.62 -9.01 -0.44 1.61e-17 Bone mineral density; LUSC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg14983838 chr19:29218262 NA 0.49 5.97 0.31 5.93e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg13012494 chr21:47604986 C21orf56 0.39 5.75 0.3 2.01e-8 Testicular germ cell tumor; LUSC cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg21427119 chr20:30132790 HM13 0.37 5.65 0.3 3.5e-8 Mean corpuscular hemoglobin; LUSC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg06008330 chr7:65541103 ASL -0.4 -6.28 -0.32 1.05e-9 Aortic root size; LUSC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.13e-16 Schizophrenia; LUSC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg12365402 chr11:9010492 NRIP3 0.45 8.32 0.41 2.21e-15 Hemoglobin concentration; LUSC cis rs12548874 0.607 rs12543492 chr8:95891843 C/A cg16049864 chr8:95962084 TP53INP1 -0.55 -10.06 -0.48 5.75e-21 Hemoglobin concentration; LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.39 6.2 0.32 1.7e-9 Menopause (age at onset); LUSC cis rs4588572 0.688 rs2362829 chr5:77724036 T/A cg11547950 chr5:77652471 NA -0.47 -7.15 -0.36 5.67e-12 Triglycerides; LUSC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg20573242 chr4:122745356 CCNA2 0.45 6.89 0.35 2.87e-11 Type 2 diabetes; LUSC cis rs422249 0.512 rs174576 chr11:61603510 C/A cg19610905 chr11:61596333 FADS2 -0.51 -7.99 -0.4 2.29e-14 Trans fatty acid levels; LUSC cis rs1048238 0.506 rs698889 chr1:16267040 A/C cg22431228 chr1:16359049 CLCNKA 0.41 8.37 0.42 1.55e-15 Systolic blood pressure; LUSC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.37e-9 Life satisfaction; LUSC cis rs2835872 0.965 rs717859 chr21:39012802 A/G cg20424643 chr21:39039972 KCNJ6 -0.37 -5.73 -0.3 2.19e-8 Electroencephalographic traits in alcoholism; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg19013620 chr14:90756653 C14orf102 -0.38 -6.01 -0.31 4.88e-9 N-glycan levels; LUSC cis rs1670533 1.000 rs6850784 chr4:1059809 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.03 0.31 4.23e-9 Recombination rate (females); LUSC trans rs2797160 1.000 rs1630556 chr6:126013155 A/G cg05039488 chr6:79577232 IRAK1BP1 0.44 6.58 0.34 1.85e-10 Endometrial cancer; LUSC cis rs3806843 0.966 rs1030163 chr5:140185132 G/A cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 3.09e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7582180 0.629 rs6731549 chr2:100939937 T/G cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.89e-8 Intelligence (multi-trait analysis); LUSC cis rs67366981 1.000 rs56357623 chr14:77697393 C/A cg22824376 chr14:77648248 TMEM63C 0.83 7.63 0.39 2.5e-13 Obsessive-compulsive symptoms; LUSC cis rs12575480 0.779 rs11602585 chr11:2101345 C/T cg15541987 chr11:2077307 NA -0.46 -6.6 -0.34 1.63e-10 Pursuit maintenance gain; LUSC cis rs1371867 0.846 rs1788194 chr8:101277916 T/C cg00191853 chr8:101177733 SPAG1 -0.37 -5.95 -0.31 6.76e-9 Atrioventricular conduction; LUSC cis rs17539620 0.624 rs7770107 chr6:154836862 A/G cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC trans rs76248362 0.737 rs6490836 chr13:24434585 A/G cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs2730245 0.527 rs2788470 chr7:158649801 G/T cg11984989 chr7:158649758 WDR60 1.13 13.36 0.59 6.28e-33 Height; LUSC cis rs10782582 0.609 rs5745410 chr1:76314356 C/A cg10523679 chr1:76189770 ACADM -0.49 -7.06 -0.36 9.81e-12 Daytime sleep phenotypes; LUSC cis rs6424115 0.867 rs4649119 chr1:24171543 C/G cg15997130 chr1:24165203 NA -0.52 -8.37 -0.42 1.57e-15 Immature fraction of reticulocytes; LUSC cis rs9747201 1.000 rs9747201 chr17:80177852 A/C cg18209359 chr17:80159595 CCDC57 -0.35 -5.74 -0.3 2.17e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg03433033 chr1:76189801 ACADM 0.83 13.25 0.59 1.78e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9467773 0.525 rs1535274 chr6:26520747 A/C cg05738196 chr6:26577821 NA 0.74 12.18 0.55 1.72e-28 Intelligence (multi-trait analysis); LUSC cis rs13253111 0.967 rs7821358 chr8:28060690 A/G cg26534493 chr8:28060551 NA 0.46 8.74 0.43 1.12e-16 Childhood body mass index; LUSC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg04248312 chr19:17393744 ANKLE1 -0.93 -15.12 -0.64 1.05e-39 Systemic lupus erythematosus; LUSC cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg22529645 chr1:3704559 LRRC47 0.37 6.22 0.32 1.46e-9 Red cell distribution width; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.51e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7180079 1.000 rs12903745 chr15:64632840 G/A cg02848875 chr15:64387786 SNX1 0.4 5.76 0.3 1.92e-8 Monocyte count; LUSC cis rs11583043 0.708 rs1060481 chr1:101546699 A/G cg11406453 chr1:101602562 NA -0.41 -6.84 -0.35 3.76e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6964587 1.000 rs28927678 chr7:91715662 C/T cg17063962 chr7:91808500 NA 0.57 8.69 0.43 1.66e-16 Breast cancer; LUSC trans rs561341 1.000 rs537166 chr17:30326827 C/T cg20587970 chr11:113659929 NA -1.16 -16.05 -0.66 2.24e-43 Hip circumference adjusted for BMI; LUSC trans rs877282 0.685 rs56234340 chr10:781339 A/G cg22713356 chr15:30763199 NA 0.93 12.91 0.58 3.25e-31 Uric acid levels; LUSC trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs16937 0.640 rs6664706 chr1:205182563 T/C cg21643547 chr1:205240462 TMCC2 -0.36 -6.42 -0.33 4.72e-10 Schizophrenia; LUSC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg17971929 chr21:40555470 PSMG1 0.79 13.73 0.6 2.61e-34 Cognitive function; LUSC cis rs2806561 0.929 rs2903545 chr1:23541108 C/T cg19743168 chr1:23544995 NA -0.46 -10.03 -0.48 7.03e-21 Height; LUSC cis rs9905704 0.918 rs694720 chr17:56708019 T/C cg12560992 chr17:57184187 TRIM37 0.54 7.72 0.39 1.36e-13 Testicular germ cell tumor; LUSC cis rs7113850 0.541 rs11826483 chr11:24237730 C/T ch.11.24196551F chr11:24239977 NA 1.0 9.1 0.45 8.45e-18 Bone fracture in osteoporosis; LUSC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.75 -0.35 6.64e-11 Blood protein levels; LUSC cis rs2486288 0.656 rs7171312 chr15:45570225 C/G cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.84 -0.51 1.2e-23 Glomerular filtration rate; LUSC cis rs2832077 0.943 rs11702320 chr21:30195251 A/T cg08807101 chr21:30365312 RNF160 -0.53 -6.68 -0.34 9.85e-11 Cognitive test performance; LUSC cis rs752010 0.574 rs6671999 chr1:42120416 G/A cg06885757 chr1:42089581 HIVEP3 0.44 9.33 0.45 1.49e-18 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7264396 0.733 rs6060515 chr20:34211779 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.79 -0.47 4.54e-20 Total cholesterol levels; LUSC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg22791324 chr7:157949174 PTPRN2 0.29 5.84 0.3 1.21e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg16325326 chr1:53192061 ZYG11B 0.97 19.12 0.72 1.4e-55 Monocyte count; LUSC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg20302533 chr7:39170763 POU6F2 0.57 9.32 0.45 1.63e-18 IgG glycosylation; LUSC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg17340268 chr14:105411764 AHNAK2 -0.37 -5.93 -0.31 7.4e-9 Rheumatoid arthritis; LUSC trans rs3960554 0.529 rs7800970 chr7:75880198 C/T cg19862616 chr7:65841803 NCRNA00174 -0.61 -7.63 -0.39 2.47e-13 Eotaxin levels; LUSC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg07777115 chr5:623756 CEP72 -0.46 -5.93 -0.31 7.72e-9 Obesity-related traits; LUSC cis rs3092073 0.624 rs3848719 chr20:44596545 G/A cg27529037 chr20:44575021 PCIF1 0.43 7.56 0.38 3.81e-13 Intelligence (multi-trait analysis); LUSC cis rs9790314 0.846 rs7636941 chr3:160993928 A/G cg03342759 chr3:160939853 NMD3 -0.57 -9.78 -0.47 4.88e-20 Morning vs. evening chronotype; LUSC cis rs7575217 0.588 rs11675224 chr2:101670955 C/T cg23907051 chr2:101730305 TBC1D8 0.27 6.62 0.34 1.44e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs11098499 0.779 rs72918579 chr4:120333222 G/C cg24375607 chr4:120327624 NA 0.76 11.1 0.52 1.42e-24 Corneal astigmatism; LUSC cis rs9435341 0.762 rs2878349 chr1:107549245 G/A cg15468180 chr1:107600409 PRMT6 0.38 5.83 0.3 1.32e-8 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs4964805 0.802 rs11111778 chr12:104185431 G/A cg02344784 chr12:104178138 NT5DC3 0.41 6.47 0.33 3.45e-10 Attention deficit hyperactivity disorder; LUSC trans rs6502050 0.835 rs35192339 chr17:80119106 G/A cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs6906287 0.625 rs9320648 chr6:118690014 A/C cg21191810 chr6:118973309 C6orf204 0.38 6.88 0.35 3.01e-11 Electrocardiographic conduction measures; LUSC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg09323728 chr8:95962352 TP53INP1 0.38 7.7 0.39 1.58e-13 Type 2 diabetes; LUSC cis rs12210905 0.800 rs12201890 chr6:26662626 A/C cg11502198 chr6:26597334 ABT1 -0.74 -5.77 -0.3 1.8e-8 Hip circumference adjusted for BMI; LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg05896524 chr21:47604654 C21orf56 0.5 7.69 0.39 1.64e-13 Testicular germ cell tumor; LUSC cis rs7659604 0.728 rs6852923 chr4:122688324 G/A cg19748678 chr4:122722346 EXOSC9 0.65 9.81 0.47 3.98e-20 Type 2 diabetes; LUSC cis rs6754311 0.550 rs10173394 chr2:136522675 C/T cg07169764 chr2:136633963 MCM6 -0.59 -7.76 -0.39 1.02e-13 Mosquito bite size; LUSC cis rs13082711 0.911 rs11719386 chr3:27505636 G/C cg02860705 chr3:27208620 NA 0.49 8.2 0.41 5.36e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6546886 0.912 rs13006407 chr2:74280275 G/A cg14702570 chr2:74259524 NA -0.31 -5.74 -0.3 2.07e-8 Dialysis-related mortality; LUSC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs4253772 0.938 rs77378083 chr22:46639386 G/A cg18190219 chr22:46762943 CELSR1 -0.52 -6.01 -0.31 4.77e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs600231 0.542 rs11227198 chr11:65237974 G/A cg17120908 chr11:65337727 SSSCA1 -0.62 -8.95 -0.44 2.47e-17 Bone mineral density; LUSC cis rs12210905 0.748 rs6901225 chr6:26670491 A/G cg11502198 chr6:26597334 ABT1 -0.71 -6.38 -0.33 6.05e-10 Hip circumference adjusted for BMI; LUSC cis rs12220238 1.000 rs6480723 chr10:75966366 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.22 0.37 3.42e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg03146154 chr1:46216737 IPP 0.5 7.49 0.38 6.02e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs73200209 0.744 rs7314858 chr12:116565050 T/C cg01776926 chr12:116560359 MED13L -0.5 -6.06 -0.31 3.58e-9 Total body bone mineral density; LUSC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg16797656 chr11:68205561 LRP5 0.4 7.26 0.37 2.67e-12 Total body bone mineral density; LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.64 -11.27 -0.52 3.43e-25 Menopause (age at onset); LUSC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg11102782 chr19:18549136 ISYNA1 -0.35 -6.5 -0.34 2.93e-10 Breast cancer; LUSC cis rs10208940 0.920 rs13400463 chr2:68723912 G/A cg12452813 chr2:68675892 NA 0.58 5.95 0.31 6.61e-9 Urate levels in lean individuals; LUSC cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.59 -0.34 1.69e-10 Response to bleomycin (chromatid breaks); LUSC cis rs9527 0.590 rs11191544 chr10:104827198 C/G cg23093090 chr10:104574429 C10orf26 -0.37 -6.67 -0.34 1.04e-10 Arsenic metabolism; LUSC cis rs6142102 0.961 rs1055857 chr20:32613873 A/G cg08999081 chr20:33150536 PIGU 0.35 5.99 0.31 5.29e-9 Skin pigmentation; LUSC cis rs7605827 0.930 rs4133515 chr2:15696655 A/G cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.32e-17 Educational attainment (years of education); LUSC cis rs73206853 0.841 rs28480627 chr12:110834659 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.51e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs7246967 0.611 rs3931771 chr19:22896820 A/G cg23217946 chr19:22817039 ZNF492 0.41 5.68 0.3 2.93e-8 Bronchopulmonary dysplasia; LUSC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.48 0.46 5e-19 Mean platelet volume; LUSC cis rs11155671 0.530 rs6935829 chr6:150217811 C/T cg09699651 chr6:150184138 LRP11 0.47 7.47 0.38 7.12e-13 Testicular germ cell tumor; LUSC trans rs11039798 0.688 rs12277029 chr11:48852833 G/T cg15704280 chr7:45808275 SEPT13 0.78 7.46 0.38 7.71e-13 Axial length; LUSC cis rs12618769 0.656 rs56091613 chr2:99103761 A/G cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs7089973 0.604 rs2420066 chr10:116583897 A/G cg03647239 chr10:116582469 FAM160B1 0.45 7.21 0.37 3.81e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs274567 0.599 rs11242110 chr5:131743777 A/C cg24060327 chr5:131705240 SLC22A5 0.42 6.57 0.34 1.95e-10 Blood metabolite levels; LUSC cis rs7249142 0.512 rs12981160 chr19:19298099 T/A cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.54 9.05 0.44 1.2e-17 IgG glycosylation; LUSC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg08470875 chr2:26401718 FAM59B -0.68 -9.08 -0.45 9.33e-18 Gut microbiome composition (summer); LUSC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.89 14.48 0.62 3.16e-37 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs8042849 1 rs8042849 chr15:78817929 C/T cg18825076 chr15:78729989 IREB2 0.49 7.86 0.4 5.37e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Parental lifespan;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg06238570 chr21:40685208 BRWD1 0.61 10.13 0.48 3.34e-21 Cognitive function; LUSC cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.78 -10.05 -0.48 6.14e-21 Gut microbiome composition (summer); LUSC cis rs7267979 0.966 rs6083817 chr20:25343998 G/C cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10256972 0.630 rs10282584 chr7:1081442 C/T cg08132940 chr7:1081526 C7orf50 0.35 6.34 0.33 7.56e-10 Longevity;Endometriosis; LUSC cis rs2625529 0.824 rs11072346 chr15:72400434 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.64 -0.39 2.26e-13 Red blood cell count; LUSC cis rs2078087 0.522 rs649954 chr1:183216448 G/A cg13843938 chr1:183241246 NMNAT2 0.41 6.77 0.35 5.85e-11 Obesity-related traits; LUSC cis rs981844 1.000 rs62325083 chr4:154661775 T/C cg14289246 chr4:154710475 SFRP2 0.5 6.44 0.33 4.05e-10 Response to statins (LDL cholesterol change); LUSC cis rs6546550 0.935 rs13392884 chr2:70036711 A/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.15 -0.36 5.44e-12 Prevalent atrial fibrillation; LUSC cis rs9430161 0.611 rs12081181 chr1:11034165 T/G cg02454025 chr1:11042201 C1orf127 1.04 19.33 0.73 2.07e-56 Ewing sarcoma; LUSC cis rs11190604 1.000 rs1054399 chr10:102312565 C/T cg07080220 chr10:102295463 HIF1AN 0.68 9.06 0.44 1.15e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11644478 chr21:40555479 PSMG1 -0.57 -8.25 -0.41 3.74e-15 Menarche (age at onset); LUSC cis rs9875589 1.000 rs9875589 chr3:13961157 A/C cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.33 -5.74 -0.3 2.11e-8 Ovarian reserve; LUSC cis rs10791323 0.569 rs10791335 chr11:133739571 A/T cg15485101 chr11:133734466 NA 0.36 6.74 0.35 7.07e-11 Childhood ear infection; LUSC cis rs4969178 0.641 rs4969141 chr17:76391653 C/T cg05887092 chr17:76393375 PGS1 0.65 12.8 0.57 8.8e-31 HDL cholesterol levels; LUSC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg21251018 chr6:28226885 NKAPL 0.31 5.9 0.31 9.02e-9 Pubertal anthropometrics; LUSC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.81 12.23 0.56 1.16e-28 Cognitive test performance; LUSC cis rs7144547 0.803 rs8008602 chr14:81890171 T/A cg23690444 chr14:81902736 NA 0.42 5.88 0.31 9.87e-9 Prudent dietary pattern; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01626569 chr16:20911881 LYRM1;DCUN1D3 -0.51 -6.78 -0.35 5.55e-11 Bipolar disorder and schizophrenia; LUSC cis rs155346 1.000 rs6891658 chr5:139403517 A/G cg01090482 chr5:139365336 NRG2 -0.37 -5.88 -0.31 1.01e-8 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC trans rs2727020 0.553 rs3907576 chr11:49536639 A/C cg03929089 chr4:120376271 NA -0.95 -16.06 -0.66 2.15e-43 Coronary artery disease; LUSC trans rs6600671 1.000 rs12145080 chr1:121185531 C/T cg00646200 chr1:148855367 NA -0.48 -7.71 -0.39 1.45e-13 Hip geometry; LUSC cis rs1865760 0.568 rs2032450 chr6:25993114 C/G cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.08e-11 Height; LUSC cis rs6967385 0.538 rs10275154 chr7:12355002 T/C cg10578991 chr7:12443926 VWDE 0.39 5.85 0.3 1.18e-8 Response to taxane treatment (placlitaxel); LUSC trans rs61931739 0.534 rs12372721 chr12:34175301 C/T cg26384229 chr12:38710491 ALG10B 0.74 11.95 0.55 1.17e-27 Morning vs. evening chronotype; LUSC cis rs4919694 1.000 rs12252500 chr10:104794984 G/C cg04362960 chr10:104952993 NT5C2 1.17 13.66 0.6 4.72e-34 Arsenic metabolism; LUSC cis rs1801251 0.964 rs7589201 chr2:233724536 A/G cg08000102 chr2:233561755 GIGYF2 -0.69 -11.41 -0.53 1.08e-25 Coronary artery disease; LUSC cis rs9902453 0.817 rs9909128 chr17:28161482 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.36 0.53 1.62e-25 Coffee consumption (cups per day); LUSC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -6.9 -0.35 2.59e-11 Alzheimer's disease (late onset); LUSC cis rs6942756 1.000 rs11979476 chr7:128993756 G/T cg02491457 chr7:128862824 NA 0.54 7.19 0.37 4.4e-12 White matter hyperintensity burden; LUSC cis rs5758659 0.652 rs133313 chr22:42401749 G/T cg04733989 chr22:42467013 NAGA 0.39 6.55 0.34 2.2e-10 Cognitive function; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11311579 chr10:102106754 SCD -0.41 -6.13 -0.32 2.42e-9 Electrocardiographic conduction measures; LUSC cis rs17125944 0.615 rs12589020 chr14:53312002 C/T cg00686598 chr14:53173677 PSMC6 0.83 7.21 0.37 3.65e-12 Alzheimer's disease (late onset); LUSC trans rs2797160 1.000 rs2211419 chr6:125995533 C/T cg05039488 chr6:79577232 IRAK1BP1 0.45 6.63 0.34 1.36e-10 Endometrial cancer; LUSC cis rs1506636 0.886 rs6945841 chr7:123266094 G/A cg03229431 chr7:123269106 ASB15 -0.69 -11.48 -0.53 6.28e-26 Plateletcrit;Platelet count; LUSC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg00046913 chr16:1877150 HAGH;FAHD1 0.55 6.0 0.31 5.16e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs539096 0.540 rs37452 chr1:44297573 A/C cg13246856 chr1:44399776 ARTN 0.26 5.79 0.3 1.63e-8 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs78941440 chr8:58052095 A/G cg22535103 chr8:58192502 C8orf71 -0.56 -6.74 -0.35 7.17e-11 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.1 -0.41 1.05e-14 Lung cancer; LUSC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg08859206 chr1:53392774 SCP2 -0.4 -6.47 -0.33 3.41e-10 Monocyte count; LUSC cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg05985134 chr18:33552581 C18orf21 0.5 7.07 0.36 9.21e-12 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs3733585 0.781 rs57250714 chr4:9984529 C/T cg26043149 chr18:55253948 FECH 0.47 7.32 0.37 1.84e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg18230493 chr5:56204884 C5orf35 -0.76 -12.81 -0.57 7.56e-31 Initial pursuit acceleration; LUSC trans rs11098499 0.865 rs2389809 chr4:120377399 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.06 0.4 1.41e-14 Corneal astigmatism; LUSC cis rs7772486 0.875 rs2328712 chr6:146344563 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.08 -0.36 8.5e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4356932 1.000 rs7655350 chr4:76977073 A/C cg00809888 chr4:76862425 NAAA 0.34 5.7 0.3 2.6e-8 Blood protein levels; LUSC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg23711669 chr6:146136114 FBXO30 0.7 10.69 0.5 3.89e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg10360139 chr7:1886902 MAD1L1 -0.42 -6.34 -0.33 7.66e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.57 8.11 0.41 9.56e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg03233332 chr7:66118400 NA -0.41 -5.96 -0.31 6.35e-9 Aortic root size; LUSC cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg18252515 chr7:66147081 NA -0.58 -7.89 -0.4 4.31e-14 Corneal structure; LUSC cis rs12042938 0.935 rs823159 chr1:231777168 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 6.21 0.32 1.6e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs936229 0.813 rs3784790 chr15:75081745 G/C cg10253484 chr15:75165896 SCAMP2 -0.51 -6.77 -0.35 5.7e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7927592 0.913 rs10896347 chr11:68353127 G/A cg20283391 chr11:68216788 NA -0.61 -8.42 -0.42 1.15e-15 Total body bone mineral density; LUSC cis rs59698941 0.943 rs59484796 chr5:132293543 C/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs1577917 1.000 rs2816815 chr6:86691656 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.34 -0.42 2.01e-15 Response to antipsychotic treatment; LUSC cis rs7089973 0.646 rs35453961 chr10:116638166 T/C cg03647239 chr10:116582469 FAM160B1 0.43 6.56 0.34 2.09e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -7.34 -0.37 1.6e-12 Menarche (age at onset); LUSC cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg23173402 chr1:227635558 NA 0.59 7.08 0.36 8.53e-12 Major depressive disorder; LUSC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg12639453 chr1:2035780 PRKCZ 0.3 6.31 0.33 8.91e-10 Height; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg20295408 chr7:1910781 MAD1L1 -0.45 -6.47 -0.33 3.58e-10 Bipolar disorder and schizophrenia; LUSC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg16145915 chr7:1198662 ZFAND2A -0.42 -5.96 -0.31 6.54e-9 Bronchopulmonary dysplasia; LUSC cis rs2237234 0.580 rs7763910 chr6:26472655 C/T cg12292205 chr6:26970375 C6orf41 -0.42 -6.78 -0.35 5.5e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7267979 0.816 rs404775 chr20:25481117 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.25 0.66 3.75e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12545109 0.800 rs2576591 chr8:57423606 A/G cg09654669 chr8:57350985 NA -0.47 -6.42 -0.33 4.71e-10 Obesity-related traits; LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg16325326 chr1:53192061 ZYG11B 0.87 16.07 0.66 1.89e-43 Monocyte count; LUSC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg00784671 chr22:46762841 CELSR1 -0.61 -6.64 -0.34 1.27e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs12891047 0.934 rs10483805 chr14:68255651 T/C cg20999565 chr14:68265668 ZFYVE26 -0.37 -5.82 -0.3 1.41e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9486715 0.867 rs211159 chr6:97023026 G/A cg06623918 chr6:96969491 KIAA0776 -0.92 -17.08 -0.68 1.83e-47 Headache; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg14004847 chr7:1930337 MAD1L1 0.5 7.68 0.39 1.73e-13 Bipolar disorder and schizophrenia; LUSC cis rs7246967 0.673 rs12978964 chr19:22819244 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs75920871 0.528 rs7950093 chr11:116963519 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.47 -5.98 -0.31 5.87e-9 Subjective well-being; LUSC cis rs2412459 0.536 rs7173301 chr15:40269843 C/T cg25407064 chr15:40226267 EIF2AK4 0.52 6.14 0.32 2.29e-9 Response to haloperidol in psychosis; LUSC cis rs250677 0.687 rs250663 chr5:148453117 T/C cg18129178 chr5:148520854 ABLIM3 -0.7 -10.7 -0.51 3.48e-23 Breast cancer; LUSC cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg14993813 chr1:46806288 NSUN4 -0.53 -7.35 -0.37 1.55e-12 Menopause (age at onset); LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg25036284 chr2:26402008 FAM59B -0.7 -9.62 -0.47 1.69e-19 Gut microbiome composition (summer); LUSC cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.73e-15 Homoarginine levels; LUSC cis rs8072100 0.967 rs11871606 chr17:45732774 G/T cg08085267 chr17:45401833 C17orf57 0.54 8.8 0.43 7.28e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9486719 1.000 rs4839837 chr6:96908706 G/A cg06623918 chr6:96969491 KIAA0776 0.75 9.82 0.47 3.7799999999999997e-20 Migraine;Coronary artery disease; LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC cis rs7597155 0.905 rs6710136 chr2:69986256 T/C cg02498382 chr2:70120550 SNRNP27 -0.24 -5.75 -0.3 1.99e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9393777 0.623 rs9348719 chr6:26470032 T/C cg05738196 chr6:26577821 NA -0.52 -5.64 -0.3 3.56e-8 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.931 rs12776390 chr10:35391535 T/G cg03585969 chr10:35415529 CREM 0.62 9.12 0.45 6.97e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.56 8.89 0.44 3.85e-17 Multiple sclerosis; LUSC cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg16230307 chr14:35515116 FAM177A1 0.74 8.83 0.43 6.15e-17 Psoriasis; LUSC trans rs4460079 0.531 rs7658266 chr4:114863706 C/T cg23278040 chr19:266712 NA 0.46 6.1 0.32 3.01e-9 Blood pressure measurement (high sodium and potassium intervention); LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.47 -0.38 6.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg21535247 chr6:8435926 SLC35B3 0.59 8.99 0.44 1.91e-17 Motion sickness; LUSC cis rs3770081 1.000 rs2289237 chr2:86266274 C/G cg23655155 chr2:86332777 POLR1A;PTCD3 1.03 6.96 0.36 1.81e-11 Facial emotion recognition (sad faces); LUSC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg17971929 chr21:40555470 PSMG1 0.76 12.5 0.56 1.15e-29 Cognitive function; LUSC cis rs4792901 0.759 rs1382685 chr17:41563151 G/A cg22562494 chr17:41607896 ETV4 -0.34 -6.53 -0.34 2.45e-10 Dupuytren's disease; LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg23159081 chr2:198364596 HSPD1;HSPE1 0.42 6.29 0.33 1.01e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs72781680 1.000 rs55773155 chr2:24255081 A/G cg08917208 chr2:24149416 ATAD2B 0.98 9.81 0.47 4.02e-20 Lymphocyte counts; LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.69 -10.09 -0.48 4.37e-21 Systemic lupus erythematosus; LUSC cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg17420585 chr12:42539391 GXYLT1 -0.36 -7.04 -0.36 1.11e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs34421088 0.506 rs4841519 chr8:11146228 A/T cg21775007 chr8:11205619 TDH 0.46 7.13 0.36 6.09e-12 Neuroticism; LUSC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg24977027 chr2:88469347 THNSL2 0.56 5.86 0.31 1.11e-8 Plasma clusterin levels; LUSC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg09796270 chr17:17721594 SREBF1 0.4 7.07 0.36 9.07e-12 Total body bone mineral density; LUSC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg20476274 chr7:133979776 SLC35B4 0.83 15.14 0.64 8.94e-40 Mean platelet volume; LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg08859206 chr1:53392774 SCP2 0.56 9.77 0.47 5.43e-20 Monocyte count; LUSC cis rs11190604 1.000 rs6584379 chr10:102224490 G/A cg07080220 chr10:102295463 HIF1AN 0.65 8.72 0.43 1.34e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2692947 0.599 rs7561198 chr2:96774981 C/G cg23100626 chr2:96804247 ASTL -0.31 -7.32 -0.37 1.83e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg25019033 chr10:957182 NA 0.52 5.86 0.31 1.11e-8 Eosinophil percentage of granulocytes; LUSC cis rs4820539 0.966 rs5759600 chr22:23483769 C/A cg14186256 chr22:23484241 RTDR1 0.93 17.13 0.68 1.22e-47 Bone mineral density; LUSC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg13939156 chr17:80058883 NA 0.34 6.77 0.35 5.94e-11 Life satisfaction; LUSC cis rs7113850 0.541 rs79932281 chr11:24231839 T/G ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Bone fracture in osteoporosis; LUSC cis rs4072705 0.614 rs1570581 chr9:127234059 A/G cg13476313 chr9:127244764 NR5A1 0.34 6.54 0.34 2.34e-10 Menarche (age at onset); LUSC cis rs7666738 0.515 rs28615369 chr4:98896858 C/T cg05340658 chr4:99064831 C4orf37 0.59 9.04 0.44 1.31e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs10740039 0.883 rs7089720 chr10:62393821 G/T cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9472414 0.771 rs2139863 chr6:44796139 A/G cg20913747 chr6:44695427 NA 0.4 5.69 0.3 2.83e-8 Height; LUSC cis rs11583043 0.708 rs915405 chr1:101574145 T/C cg11406453 chr1:101602562 NA -0.4 -6.9 -0.35 2.6e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs3020736 0.500 rs4147641 chr22:42482502 C/G cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC trans rs7937682 0.889 rs493810 chr11:111491888 G/T cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs7833986 0.501 rs2976044 chr8:56986737 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.71 12.39 0.56 2.78e-29 Height; LUSC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg16743903 chr16:89593216 SPG7 -0.4 -6.18 -0.32 1.84e-9 Multiple myeloma (IgH translocation); LUSC trans rs6952808 0.964 rs10950400 chr7:1882470 C/T cg24247370 chr13:99142703 STK24 -0.34 -6.15 -0.32 2.21e-9 Bipolar disorder and schizophrenia; LUSC cis rs10752881 1.000 rs6424880 chr1:182986679 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.77 7.65 0.39 2.1e-13 Initial pursuit acceleration; LUSC cis rs12989701 1.000 rs12989701 chr2:127887985 C/A cg08168897 chr2:127865431 BIN1 0.71 8.27 0.41 3.25e-15 Alzheimer's disease (late onset); LUSC cis rs2425143 1.000 rs1970357 chr20:34339200 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.59 6.29 0.33 1.02e-9 Blood protein levels; LUSC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg03929089 chr4:120376271 NA -1.03 -20.21 -0.74 7.12e-60 Height; LUSC cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.99 0.36 1.46e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs10506458 0.688 rs60936040 chr12:63416461 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.05 -14.65 -0.63 7.2700000000000005e-38 Hemostatic factors and hematological phenotypes; LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs12208915 0.559 rs4706738 chr6:79514153 A/G cg18132916 chr6:79620363 NA 0.39 5.64 0.3 3.57e-8 Left atrial antero-posterior diameter; LUSC cis rs6121246 0.559 rs6058465 chr20:30397691 G/A cg13852791 chr20:30311386 BCL2L1 0.92 14.19 0.61 4.35e-36 Mean corpuscular hemoglobin; LUSC cis rs7577696 0.597 rs6756085 chr2:32336522 A/G cg02381751 chr2:32503542 YIPF4 -0.51 -6.88 -0.35 2.93e-11 Inflammatory biomarkers; LUSC cis rs9905704 0.645 rs17175543 chr17:56803598 G/T cg12560992 chr17:57184187 TRIM37 0.5 5.84 0.3 1.22e-8 Testicular germ cell tumor; LUSC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg18876405 chr7:65276391 NA 0.6 9.67 0.47 1.14e-19 Aortic root size; LUSC cis rs9660992 0.762 rs1172129 chr1:205244972 T/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.46 -0.46 5.79e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6688613 0.685 rs61815130 chr1:166910465 T/C cg07049167 chr1:166818506 POGK 0.45 6.5 0.34 2.95e-10 Refractive astigmatism; LUSC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg06637938 chr14:75390232 RPS6KL1 0.54 8.65 0.43 2.16e-16 Height; LUSC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.26 -0.41 3.38e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2404602 0.552 rs11072613 chr15:76961526 A/C cg23625390 chr15:77176239 SCAPER -0.56 -7.96 -0.4 2.63e-14 Blood metabolite levels; LUSC cis rs11098499 0.954 rs35091806 chr4:120325529 G/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs1395 0.778 rs11693660 chr2:27468856 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.25 0.37 2.94e-12 Blood metabolite levels; LUSC cis rs9393777 0.623 rs7756567 chr6:26481642 T/G cg12826209 chr6:26865740 GUSBL1 0.68 7.67 0.39 1.85e-13 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg00750074 chr16:89608354 SPG7 -0.54 -9.82 -0.47 3.67e-20 Multiple myeloma (IgH translocation); LUSC cis rs4566357 0.595 rs10201538 chr2:227914449 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -8.2 -0.41 5.4e-15 Coronary artery disease; LUSC cis rs6906287 0.647 rs973944 chr6:118850956 T/G cg21191810 chr6:118973309 C6orf204 0.32 5.83 0.3 1.27e-8 Electrocardiographic conduction measures; LUSC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg04800585 chr6:26043546 HIST1H2BB 0.43 6.4 0.33 5.28e-10 Intelligence (multi-trait analysis); LUSC cis rs9398803 0.830 rs1159619 chr6:126801144 C/A cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.9e-9 Male-pattern baldness; LUSC cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.99 0.55 8.55e-28 Chronic sinus infection; LUSC trans rs1133146 1.000 rs1133146 chr19:53666660 A/G cg23709988 chr14:23772096 PPP1R3E -0.4 -6.31 -0.33 8.62e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg24399712 chr22:39784796 NA -0.61 -10.86 -0.51 1.01e-23 Intelligence (multi-trait analysis); LUSC cis rs9287719 0.967 rs4284804 chr2:10722124 C/T cg03983476 chr2:10830698 NOL10 -0.37 -5.66 -0.3 3.31e-8 Prostate cancer; LUSC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg17385448 chr1:15911702 AGMAT 0.35 5.97 0.31 6.18e-9 Systolic blood pressure; LUSC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.56 0.46 2.7e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs116988415 0.584 rs2269306 chr14:65245417 A/G cg25083366 chr14:65239357 SPTB -0.57 -6.04 -0.31 4e-9 Daytime sleep phenotypes; LUSC cis rs7681440 0.904 rs7672979 chr4:90767873 A/G cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24997989 chr18:21977798 OSBPL1A -0.41 -6.37 -0.33 6.29e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs11992162 0.560 rs13256329 chr8:11782214 G/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.37 -0.33 6.25e-10 Monocyte count; LUSC cis rs73206853 0.702 rs7960516 chr12:110529238 T/A cg12870014 chr12:110450643 ANKRD13A 0.48 6.3 0.33 9.17e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg22875332 chr1:76189707 ACADM 0.8 12.63 0.57 3.72e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs34172651 0.797 rs12920941 chr16:24830866 T/A cg00339695 chr16:24857497 SLC5A11 0.35 6.09 0.32 3.03e-9 Intelligence (multi-trait analysis); LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg07507251 chr3:52567010 NT5DC2 0.29 5.68 0.3 2.96e-8 Bipolar disorder; LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg08219700 chr8:58056026 NA 0.64 8.51 0.42 5.97e-16 Developmental language disorder (linguistic errors); LUSC cis rs3771570 1.000 rs62193171 chr2:242276523 C/A cg21155796 chr2:242212141 HDLBP 0.63 6.86 0.35 3.32e-11 Prostate cancer; LUSC cis rs2979489 0.699 rs17554116 chr8:30419334 C/T cg26383811 chr8:30366931 RBPMS -0.44 -6.65 -0.34 1.17e-10 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs858239 0.601 rs1034963 chr7:23148473 T/C cg23682824 chr7:23144976 KLHL7 0.39 5.81 0.3 1.48e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs11166629 0.637 rs721000 chr8:135574196 T/C cg27224718 chr8:135614730 ZFAT 0.57 8.1 0.41 1.05e-14 Smoking quantity; LUSC cis rs4285028 0.580 rs12496036 chr3:121640362 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.48 -6.68 -0.34 9.9e-11 Multiple sclerosis; LUSC cis rs6138458 0.585 rs1007881 chr20:25014385 A/G cg26195577 chr20:24973756 C20orf3 0.71 10.78 0.51 1.83e-23 Blood protein levels; LUSC cis rs11190604 1.000 rs11190597 chr10:102293676 A/T cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9399401 0.845 rs263187 chr6:142860789 G/A cg03128060 chr6:142623767 GPR126 0.32 5.96 0.31 6.54e-9 Chronic obstructive pulmonary disease; LUSC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs9393777 0.778 rs66841633 chr6:27382386 G/T cg09904177 chr6:26538194 HMGN4 -0.75 -5.79 -0.3 1.61e-8 Intelligence (multi-trait analysis); LUSC cis rs231513 0.954 rs231512 chr17:41965831 G/A cg26893861 chr17:41843967 DUSP3 -0.55 -6.12 -0.32 2.65e-9 Cognitive function; LUSC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7582720 1.000 rs7605484 chr2:203724495 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.06 0.4 1.37e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs7615952 0.611 rs2971298 chr3:125602713 G/A cg05084668 chr3:125655381 ALG1L -0.84 -11.99 -0.55 8.7300000000000009e-28 Blood pressure (smoking interaction); LUSC cis rs12928939 0.815 rs1345868 chr16:71669624 G/T cg08717414 chr16:71523259 ZNF19 -0.42 -5.99 -0.31 5.3e-9 Post bronchodilator FEV1; LUSC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg25643088 chr3:52874325 TMEM110 0.39 5.82 0.3 1.4e-8 Schizophrenia; LUSC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg05368731 chr17:41323189 NBR1 0.84 13.95 0.61 3.6e-35 Menopause (age at onset); LUSC cis rs965469 0.947 rs7274193 chr20:3329750 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.3 3.48e-8 IFN-related cytopenia; LUSC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg11812906 chr14:75593930 NEK9 -0.65 -11.1 -0.52 1.41e-24 Height; LUSC trans rs6828577 0.626 rs17642633 chr4:119412100 A/G cg26518628 chr1:97050305 NA -0.53 -7.41 -0.38 1.03e-12 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC cis rs9311676 0.656 rs34579268 chr3:58410554 C/T cg26110898 chr3:58419937 PDHB 0.4 6.55 0.34 2.17e-10 Systemic lupus erythematosus; LUSC cis rs8060686 0.641 rs79719939 chr16:68240216 A/G cg04539111 chr16:67997858 SLC12A4 -0.43 -5.68 -0.3 2.96e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs8060686 0.641 rs2107369 chr16:68116018 A/C cg27539214 chr16:67997921 SLC12A4 -0.54 -7.46 -0.38 7.75e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs11583043 1.000 rs7535068 chr1:101490329 T/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.88 0.31 9.87e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC trans rs61931739 0.817 rs7963318 chr12:34244929 C/G cg26384229 chr12:38710491 ALG10B -0.53 -8.5 -0.42 6.58e-16 Morning vs. evening chronotype; LUSC cis rs2797685 1.000 rs707472 chr1:7906008 A/C cg04725166 chr1:7887271 PER3 0.45 6.13 0.32 2.47e-9 Crohn's disease; LUSC cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 8.71 0.43 1.42e-16 Menarche (age at onset); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25436822 chr8:124054773 DERL1 -0.41 -5.96 -0.31 6.55e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7568458 0.846 rs10179195 chr2:85762761 A/G cg02493740 chr2:85810744 VAMP5 -0.36 -6.44 -0.33 4.13e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.54 -7.79 -0.39 8.82e-14 Gut microbiome composition (summer); LUSC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg14416269 chr4:6271139 WFS1 0.52 10.98 0.52 3.62e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg11764359 chr7:65958608 NA 0.51 6.55 0.34 2.19e-10 Aortic root size; LUSC cis rs7119 0.717 rs12910513 chr15:77817258 C/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs2806561 0.765 rs682766 chr1:23516397 C/G cg12483005 chr1:23474871 LUZP1 0.41 6.5 0.34 2.89e-10 Height; LUSC cis rs9325144 0.560 rs11182952 chr12:38636278 C/A cg26384229 chr12:38710491 ALG10B -0.66 -10.16 -0.49 2.56e-21 Morning vs. evening chronotype; LUSC cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg09035930 chr12:129282057 SLC15A4 -0.7 -15.0 -0.63 3.08e-39 Systemic lupus erythematosus; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg13560548 chr3:10150139 C3orf24 -0.52 -7.73 -0.39 1.27e-13 Alzheimer's disease; LUSC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg04398451 chr17:18023971 MYO15A -0.44 -6.93 -0.35 2.19e-11 Total body bone mineral density; LUSC cis rs12464559 0.579 rs6433590 chr2:152588120 A/C cg01189475 chr2:152685088 ARL5A 0.63 5.65 0.3 3.52e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs847577 0.609 rs7791463 chr7:97819047 G/A cg21770322 chr7:97807741 LMTK2 0.56 10.08 0.48 4.99e-21 Breast cancer; LUSC trans rs1814175 0.717 rs11040450 chr11:49650638 G/A cg15704280 chr7:45808275 SEPT13 -1.09 -21.84 -0.77 2.65e-66 Height; LUSC cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -6.88 -0.35 3.02e-11 Axial length; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg06877462 chr1:205807181 PM20D1 0.5 9.03 0.44 1.43e-17 Menarche (age at onset); LUSC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg11843238 chr5:131593191 PDLIM4 0.37 6.46 0.33 3.77e-10 Breast cancer; LUSC cis rs9902453 0.845 rs58606097 chr17:28020379 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.44 0.46 6.85e-19 Coffee consumption (cups per day); LUSC cis rs12712073 0.845 rs6729966 chr2:100781566 A/G cg07810366 chr2:100720526 AFF3 -0.42 -7.17 -0.37 5e-12 Intelligence (multi-trait analysis); LUSC cis rs924607 1.000 rs12523022 chr5:598643 C/T cg09021430 chr5:549028 NA 0.42 7.55 0.38 4.28e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg27535305 chr1:53392650 SCP2 -0.4 -7.49 -0.38 6.15e-13 Monocyte count; LUSC cis rs2078087 0.831 rs10911294 chr1:183238100 C/T cg13843938 chr1:183241246 NMNAT2 0.44 5.89 0.31 9.45e-9 Obesity-related traits; LUSC trans rs1998174 0.509 rs7514627 chr1:171812466 A/G cg13482142 chr2:234261155 NA 0.42 6.02 0.31 4.51e-9 Platelet distribution width; LUSC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.87 0.4 4.97e-14 Bipolar disorder; LUSC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg05425664 chr17:57184151 TRIM37 0.54 7.98 0.4 2.31e-14 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.931 rs58159560 chr10:35351249 C/T cg04310649 chr10:35416472 CREM -0.43 -6.55 -0.34 2.18e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg14019146 chr3:50243930 SLC38A3 0.36 8.42 0.42 1.12e-15 Body mass index; LUSC trans rs12579753 0.789 rs1343933 chr12:82123301 A/C cg07923666 chr12:49932857 KCNH3 -0.53 -6.6 -0.34 1.66e-10 Resting heart rate; LUSC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.41 -0.42 1.23e-15 Height; LUSC cis rs36093844 0.898 rs11234462 chr11:85596924 C/T cg25872744 chr11:85566296 CCDC83 -0.45 -6.81 -0.35 4.61e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs7833790 0.777 rs6473301 chr8:82691340 A/G cg02079420 chr8:82753780 SNX16 0.4 5.97 0.31 6.09e-9 Diastolic blood pressure; LUSC cis rs7560272 0.723 rs1083923 chr2:73703374 A/G cg20560298 chr2:73613845 ALMS1 0.46 7.19 0.37 4.24e-12 Schizophrenia; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.58 0.38 3.4e-13 Bipolar disorder; LUSC cis rs2274273 1.000 rs2147972 chr14:55598030 T/C cg04306507 chr14:55594613 LGALS3 0.54 11.49 0.53 5.85e-26 Protein biomarker; LUSC cis rs1865760 0.865 rs9467652 chr6:25959127 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 6.87 0.35 3.17e-11 Height; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg07167872 chr1:205819463 PM20D1 0.87 16.92 0.68 7.97e-47 Menarche (age at onset); LUSC cis rs2708377 0.658 rs2708347 chr12:11281492 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg18252515 chr7:66147081 NA -1.22 -13.8 -0.6 1.31e-34 Diabetic kidney disease; LUSC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs554111 0.613 rs6699704 chr1:21241432 G/C cg01072550 chr1:21505969 NA 0.41 6.21 0.32 1.56e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs8032315 1.000 rs8032315 chr15:91418297 A/T cg05469396 chr15:91419421 FURIN -0.42 -6.76 -0.35 6.09e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs911555 0.755 rs55742283 chr14:103942965 A/G cg24130564 chr14:104152367 KLC1 0.47 6.74 0.35 6.91e-11 Intelligence (multi-trait analysis); LUSC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg07636037 chr3:49044803 WDR6 0.44 6.51 0.34 2.69e-10 Resting heart rate; LUSC trans rs13314892 1.000 rs13314892 chr3:69795052 A/G cg24703757 chr4:183838736 DCTD 0.51 6.91 0.35 2.49e-11 QRS complex (12-leadsum); LUSC cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg11266682 chr4:10021025 SLC2A9 0.55 10.06 0.48 5.64e-21 Bone mineral density; LUSC cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg05234568 chr11:5960015 NA -0.64 -9.41 -0.46 8.5e-19 DNA methylation (variation); LUSC cis rs561341 0.609 rs7214626 chr17:30190989 G/A cg13647721 chr17:30228624 UTP6 -0.69 -7.5 -0.38 5.71e-13 Hip circumference adjusted for BMI; LUSC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg02487422 chr3:49467188 NICN1 0.44 7.13 0.36 6.21e-12 Resting heart rate; LUSC cis rs7000551 0.560 rs4872483 chr8:22255684 C/T cg12081754 chr8:22256438 SLC39A14 0.87 13.85 0.6 8.99e-35 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg11584989 chr19:19387371 SF4 -0.58 -6.85 -0.35 3.46e-11 Bipolar disorder; LUSC trans rs9467711 0.659 rs35555795 chr6:26509382 C/T cg06606381 chr12:133084897 FBRSL1 -0.75 -6.58 -0.34 1.87e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs225245 0.765 rs226428 chr17:34049950 C/T cg19694781 chr19:47549865 TMEM160 0.38 6.01 0.31 4.74e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9788682 0.706 rs2656055 chr15:78720194 C/A cg24631222 chr15:78858424 CHRNA5 -0.66 -8.51 -0.42 6.06e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs73206853 0.609 rs55833146 chr12:110872335 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 7.16 0.36 5.29e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg19748678 chr4:122722346 EXOSC9 0.73 10.83 0.51 1.3e-23 Type 2 diabetes; LUSC cis rs354225 0.544 rs4455200 chr2:54801591 T/A cg01766943 chr2:54829624 SPTBN1 0.47 7.57 0.38 3.72e-13 Schizophrenia; LUSC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg02038168 chr22:39784481 NA -0.45 -6.69 -0.34 9.39e-11 Post bronchodilator FEV1; LUSC trans rs683250 1.000 rs683125 chr11:83276245 A/G cg26617787 chr11:123396133 GRAMD1B -0.32 -6.09 -0.32 3.14e-9 Subcortical brain region volumes; LUSC cis rs8078723 0.668 rs56030650 chr17:38131187 C/A cg17467752 chr17:38218738 THRA 0.53 7.9 0.4 3.96e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs877282 0.945 rs34367686 chr10:791868 G/C cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg07636037 chr3:49044803 WDR6 1.03 18.0 0.7 3.96e-51 Parkinson's disease; LUSC cis rs72960926 0.744 rs56365866 chr6:74910810 T/C cg03266952 chr6:74778945 NA -0.78 -6.22 -0.32 1.5e-9 Metabolite levels (MHPG); LUSC cis rs2463822 0.687 rs118012228 chr11:62155914 G/A cg06239285 chr11:62104954 ASRGL1 -0.97 -10.27 -0.49 1.14e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs55665837 0.539 rs10500804 chr11:14910273 A/C cg05501817 chr11:14380813 RRAS2 -0.4 -5.86 -0.31 1.13e-8 Vitamin D levels; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 19.6 0.73 1.74e-57 Prudent dietary pattern; LUSC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg09165964 chr15:75287851 SCAMP5 0.45 6.45 0.33 3.92e-10 Caffeine consumption; LUSC cis rs9513627 0.512 rs9517759 chr13:100180108 T/G cg15490075 chr13:100150979 NA 0.66 7.99 0.4 2.18e-14 Obesity-related traits; LUSC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg24768116 chr2:27665128 KRTCAP3 -0.31 -6.09 -0.32 3.15e-9 Total body bone mineral density; LUSC cis rs12579753 0.917 rs7132465 chr12:82205840 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs13082711 0.595 rs6778612 chr3:27370789 T/C cg02860705 chr3:27208620 NA -0.68 -11.49 -0.53 5.63e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs61931739 0.649 rs860088 chr12:33721807 T/C cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.06 0.44 1.1e-17 Height; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg22907277 chr7:1156413 C7orf50 0.57 8.76 0.43 1e-16 Longevity;Endometriosis; LUSC cis rs8017423 0.967 rs2151748 chr14:90694897 G/C cg14092571 chr14:90743983 NA -0.38 -6.24 -0.32 1.31e-9 Mortality in heart failure; LUSC cis rs67072384 0.901 rs58076660 chr11:72441495 G/A cg04827223 chr11:72435913 ARAP1 -0.79 -7.42 -0.38 9.6e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs611744 0.506 rs4735054 chr8:109261780 A/C cg18478394 chr8:109455254 TTC35 -0.45 -7.02 -0.36 1.28e-11 Dupuytren's disease; LUSC cis rs7084921 0.578 rs11592631 chr10:101878219 G/A cg02250046 chr10:101825185 CPN1 -0.34 -5.99 -0.31 5.55e-9 Bone mineral density; LUSC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.44 0.33 4.12e-10 Menopause (age at onset); LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.57 0.78 3.62e-69 Prudent dietary pattern; LUSC cis rs8062405 0.755 rs62034350 chr16:28562256 A/G cg07382826 chr16:28625726 SULT1A1 0.28 5.92 0.31 8.01e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg08999081 chr20:33150536 PIGU 0.53 10.46 0.5 2.53e-22 Coronary artery disease; LUSC cis rs2219968 0.701 rs7015968 chr8:78995994 A/G cg00738934 chr8:78996279 NA 0.42 7.65 0.39 2.24e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs6845621 0.901 rs6449433 chr4:18906202 C/T cg12196642 chr4:18937545 NA 0.34 6.45 0.33 3.88e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2115536 0.606 rs8024713 chr15:80206958 C/G cg02196730 chr15:80188777 MTHFS 0.4 6.29 0.33 9.83e-10 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11039100 0.607 rs968992 chr11:5783889 G/A cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg10556349 chr10:835070 NA 0.59 6.55 0.34 2.24e-10 Eosinophil percentage of granulocytes; LUSC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg11764359 chr7:65958608 NA -0.7 -10.81 -0.51 1.53e-23 Aortic root size; LUSC cis rs12681287 0.640 rs7833049 chr8:87445898 T/C cg27223183 chr8:87520930 FAM82B 0.54 7.47 0.38 6.9e-13 Caudate activity during reward; LUSC cis rs9788682 0.792 rs35031105 chr15:78772806 C/T cg24631222 chr15:78858424 CHRNA5 0.64 8.45 0.42 9e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2067615 0.507 rs11113083 chr12:107073316 C/A cg15890332 chr12:107067104 RFX4 0.36 6.33 0.33 7.72e-10 Heart rate; LUSC cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg21643547 chr1:205240462 TMCC2 -0.53 -10.21 -0.49 1.82e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg00033643 chr7:134001901 SLC35B4 0.43 6.68 0.34 9.73e-11 Mean platelet volume; LUSC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg04317338 chr11:64019027 PLCB3 0.66 7.54 0.38 4.47e-13 Mean platelet volume; LUSC cis rs7264396 0.508 rs6060739 chr20:34567592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -7.0 -0.36 1.37e-11 Total cholesterol levels; LUSC trans rs11764590 0.950 rs55683212 chr7:2078855 G/C cg11693508 chr17:37793320 STARD3 0.52 6.14 0.32 2.28e-9 Neuroticism; LUSC trans rs11039798 0.557 rs4436575 chr11:48398894 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -7.1 -0.36 7.73e-12 Axial length; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg08736216 chr1:53307985 ZYG11A -0.27 -5.7 -0.3 2.68e-8 Monocyte count; LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.3 0.37 2.12e-12 Platelet count; LUSC cis rs2832077 0.506 rs2832085 chr21:30155258 G/T cg24692254 chr21:30365293 RNF160 -0.53 -7.08 -0.36 8.56e-12 Cognitive test performance; LUSC cis rs2439831 1.000 rs550239 chr15:43720197 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.88 0.44 4.07e-17 Lung cancer in ever smokers; LUSC cis rs612683 0.658 rs12407689 chr1:100999585 C/G cg09408571 chr1:101003634 GPR88 0.32 5.94 0.31 6.99e-9 Breast cancer; LUSC cis rs1577917 1.000 rs117907570 chr6:86601283 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.16 -0.32 2.06e-9 Response to antipsychotic treatment; LUSC trans rs2262909 0.962 rs12609368 chr19:22263996 T/C cg05197062 chr11:11642011 GALNTL4 0.57 7.91 0.4 3.71e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs17102423 0.964 rs11627859 chr14:65602384 G/A cg11161011 chr14:65562177 MAX -0.64 -9.91 -0.48 1.85e-20 Obesity-related traits; LUSC cis rs11229555 0.645 rs34350060 chr11:58184902 T/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs11577318 0.853 rs1071849 chr1:26646726 A/G cg04990556 chr1:26633338 UBXN11 -0.48 -6.18 -0.32 1.87e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6543140 0.964 rs13393175 chr2:103078849 T/G cg09003973 chr2:102972529 NA 0.54 6.87 0.35 3.16e-11 Blood protein levels; LUSC cis rs9473147 0.516 rs9381564 chr6:47443806 A/G cg12968598 chr6:47444699 CD2AP 0.54 8.14 0.41 7.83e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg17143192 chr8:8559678 CLDN23 0.63 8.9 0.44 3.56e-17 Obesity-related traits; LUSC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg27165867 chr14:105738592 BRF1 -0.51 -7.21 -0.37 3.83e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs6121246 0.529 rs6058196 chr20:30194714 A/T cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg24675658 chr1:53192096 ZYG11B 0.73 12.29 0.56 6.6e-29 Monocyte count; LUSC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg06850241 chr22:41845214 NA 0.3 5.75 0.3 2.05e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs10992471 0.676 rs13286566 chr9:95473178 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.54 -0.34 2.38e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs16854884 0.657 rs35788195 chr3:143739311 C/T cg06585982 chr3:143692056 C3orf58 0.46 7.01 0.36 1.33e-11 Economic and political preferences (feminism/equality); LUSC cis rs61931739 0.635 rs10772123 chr12:33975557 C/T cg06521331 chr12:34319734 NA -0.41 -6.94 -0.36 2.04e-11 Morning vs. evening chronotype; LUSC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg05738196 chr6:26577821 NA -0.55 -8.64 -0.43 2.32e-16 Schizophrenia; LUSC cis rs3020736 0.500 rs6002618 chr22:42507859 G/C cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs3741151 0.773 rs73542960 chr11:73115946 T/C cg17517138 chr11:73019481 ARHGEF17 0.98 8.39 0.42 1.34e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs897984 0.609 rs732173 chr16:31050023 C/A cg02466173 chr16:30829666 NA -0.54 -10.37 -0.49 5.05e-22 Dementia with Lewy bodies; LUSC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg18876405 chr7:65276391 NA -0.7 -12.56 -0.57 6.54e-30 Aortic root size; LUSC cis rs8060686 0.623 rs6499162 chr16:68239460 T/C cg05110241 chr16:68378359 PRMT7 -0.47 -6.04 -0.31 4.18e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1941023 0.584 rs2197236 chr11:60168859 T/C cg08716584 chr11:60157161 MS4A7 -0.62 -11.34 -0.53 1.9e-25 Congenital heart disease (maternal effect); LUSC cis rs11792861 0.781 rs2297581 chr9:111755008 C/T cg05043794 chr9:111880884 C9orf5 -0.37 -7.62 -0.38 2.65e-13 Menarche (age at onset); LUSC trans rs28647808 0.881 rs7040821 chr9:136263584 C/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs11608355 0.545 rs6606721 chr12:109891999 G/A cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs9807989 0.524 rs6543126 chr2:103027104 G/A cg03938978 chr2:103052716 IL18RAP 0.38 7.16 0.36 5.06e-12 Asthma; LUSC cis rs13089785 1.000 rs2271969 chr3:123650432 A/G cg02558132 chr3:123411198 MYLK 0.36 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); LUSC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg12436631 chr1:155007014 DCST1;DCST2 0.45 10.11 0.48 3.93e-21 Schizophrenia; LUSC cis rs9300255 0.739 rs1879380 chr12:123739111 G/A cg00376283 chr12:123451042 ABCB9 -0.68 -7.57 -0.38 3.59e-13 Neutrophil percentage of white cells; LUSC cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.09e-11 Height; LUSC cis rs17818399 0.547 rs7607308 chr2:46759104 T/C cg21681030 chr2:46777652 RHOQ 0.43 6.0 0.31 5e-9 Height; LUSC cis rs6754311 0.773 rs309176 chr2:136622216 T/C cg25344623 chr2:136566232 LCT 0.37 5.69 0.3 2.82e-8 Mosquito bite size; LUSC cis rs3772130 0.624 rs56382357 chr3:121452339 T/C cg20356878 chr3:121714668 ILDR1 0.51 8.26 0.41 3.43e-15 Cognitive performance; LUSC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg00074818 chr8:8560427 CLDN23 0.57 9.87 0.48 2.47e-20 Obesity-related traits; LUSC cis rs11626933 0.959 rs8005973 chr14:90774951 C/T cg14092571 chr14:90743983 NA -0.89 -18.8 -0.72 2.6e-54 Gut microbiota (bacterial taxa); LUSC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg24881330 chr22:46731750 TRMU 0.84 7.39 0.37 1.22e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs4776059 1.000 rs11857150 chr15:52922216 G/A cg25063058 chr15:52860530 ARPP19 0.42 5.93 0.31 7.42e-9 Schizophrenia; LUSC cis rs11711311 1.000 rs28394480 chr3:113485143 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.41 -5.65 -0.3 3.48e-8 IgG glycosylation; LUSC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg00750074 chr16:89608354 SPG7 -0.46 -7.98 -0.4 2.37e-14 Multiple myeloma (IgH translocation); LUSC cis rs4363385 0.818 rs3806222 chr1:153002606 C/T cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg05283184 chr6:79620031 NA -0.57 -11.83 -0.54 3.38e-27 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg15649852 chr7:65879115 NA -0.41 -5.78 -0.3 1.74e-8 Aortic root size; LUSC cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.32 0.56 5.39e-29 Chronic sinus infection; LUSC trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg15556689 chr8:8085844 FLJ10661 0.63 9.49 0.46 4.63e-19 Neuroticism; LUSC cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.95 -0.31 6.78e-9 Alcohol dependence; LUSC cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.56 0.5 1.1e-22 Drug-induced liver injury (flucloxacillin); LUSC trans rs4332037 0.901 rs7791299 chr7:1935598 T/C cg25206134 chr2:45395956 NA 0.56 6.82 0.35 4.15e-11 Bipolar disorder; LUSC trans rs9886428 1.000 rs11203588 chr8:14116631 T/A cg11959399 chr20:741723 C20orf54 -0.4 -6.42 -0.33 4.67e-10 IgG glycosylation; LUSC cis rs941764 1.000 rs941764 chr14:91841069 C/T cg10511902 chr14:91842949 CCDC88C -0.37 -6.21 -0.32 1.6e-9 Breast cancer; LUSC cis rs4363385 0.747 rs1611753 chr1:152956381 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.63 -0.39 2.41e-13 Inflammatory skin disease; LUSC cis rs7605827 0.930 rs1015835 chr2:15625768 T/C cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg21984481 chr17:79567631 NPLOC4 0.68 14.27 0.62 2.03e-36 Eye color traits; LUSC cis rs524023 0.957 rs561193 chr11:64353029 A/G cg19131476 chr11:64387923 NRXN2 0.37 10.0 0.48 8.79e-21 Urate levels in obese individuals; LUSC cis rs10979 0.679 rs9403510 chr6:143892174 C/T cg25407410 chr6:143891975 LOC285740 -0.65 -9.2 -0.45 3.88e-18 Hypospadias; LUSC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg17724175 chr1:150552817 MCL1 0.37 6.67 0.34 1.05e-10 Tonsillectomy; LUSC cis rs2540226 0.515 rs2540248 chr2:39909117 G/T cg23576258 chr2:39999331 THUMPD2 0.34 5.65 0.3 3.36e-8 Personality dimensions; LUSC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11644478 chr21:40555479 PSMG1 0.64 10.51 0.5 1.61e-22 Cognitive function; LUSC cis rs10857712 0.950 rs7906765 chr10:135225460 G/T cg01444801 chr10:135216882 MTG1 -0.49 -6.35 -0.33 7e-10 Systemic lupus erythematosus; LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg27284194 chr4:1044797 NA 0.37 5.75 0.3 2.06e-8 Longevity; LUSC cis rs7523273 0.526 rs2745975 chr1:208013620 C/T cg22525895 chr1:207977042 MIR29B2 -0.4 -6.7 -0.34 9.08e-11 Schizophrenia; LUSC trans rs4332037 0.539 rs56180486 chr7:2050747 C/T cg11693508 chr17:37793320 STARD3 0.56 6.7 0.34 8.87e-11 Bipolar disorder; LUSC cis rs4285028 0.747 rs9820511 chr3:121361345 G/A cg11130432 chr3:121712080 ILDR1 -0.58 -8.44 -0.42 9.92e-16 Multiple sclerosis; LUSC cis rs7267979 0.873 rs6083853 chr20:25404541 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.52 -0.69 3.23e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1448094 0.967 rs7974794 chr12:86323280 A/G cg18827107 chr12:86230957 RASSF9 -0.4 -5.95 -0.31 6.77e-9 Major depressive disorder; LUSC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg09021430 chr5:549028 NA -0.57 -7.7 -0.39 1.61e-13 Obesity-related traits; LUSC cis rs988712 0.705 rs35051342 chr11:27634373 G/C cg10635145 chr11:27742435 BDNF -0.5 -6.58 -0.34 1.86e-10 Obesity; LUSC cis rs892961 0.932 rs12453822 chr17:75416792 G/A cg05865280 chr17:75406074 SEPT9 0.45 9.37 0.46 1.15e-18 Airflow obstruction; LUSC cis rs2835872 0.733 rs1787393 chr21:39035934 G/A cg20424643 chr21:39039972 KCNJ6 -0.44 -7.43 -0.38 8.98e-13 Electroencephalographic traits in alcoholism; LUSC cis rs7799006 0.929 rs7781856 chr7:2257199 C/T cg12823233 chr7:2316876 SNX8 -0.36 -6.06 -0.31 3.6e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs983392 0.709 rs11601689 chr11:59996266 G/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.89 -0.31 9.34e-9 Alzheimer's disease (late onset); LUSC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg13939156 chr17:80058883 NA -0.33 -6.64 -0.34 1.24e-10 Life satisfaction; LUSC trans rs11098499 0.863 rs36040693 chr4:120477616 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.79 0.6 1.44e-34 Platelet count; LUSC cis rs6430549 0.518 rs41521049 chr2:135693069 G/A cg15893373 chr2:135677154 CCNT2 -0.47 -6.43 -0.33 4.45e-10 Hematocrit; LUSC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg08439880 chr3:133502540 NA 0.36 6.34 0.33 7.33e-10 Iron status biomarkers; LUSC cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -14.28 -0.62 1.95e-36 Chronic sinus infection; LUSC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.52 0.38 4.98e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2273669 0.667 rs112319185 chr6:109305318 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC trans rs953492 0.644 rs10926976 chr1:243402721 G/A cg25284624 chr1:224180302 NA -0.44 -6.73 -0.35 7.56e-11 Diastolic blood pressure; LUSC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.73 -12.95 -0.58 2.37e-31 Personality dimensions; LUSC cis rs208520 0.690 rs12209753 chr6:66703951 A/G cg07460842 chr6:66804631 NA 1.08 16.95 0.68 6.24e-47 Exhaled nitric oxide output; LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg19266014 chr7:2183958 MAD1L1 -0.34 -5.66 -0.3 3.27e-8 Bipolar disorder and schizophrenia; LUSC cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg12698349 chr2:225449008 CUL3 0.68 8.85 0.44 5.27e-17 IgE levels in asthmatics (D.p. specific); LUSC cis rs1728785 0.892 rs4783648 chr16:68558334 C/T cg02508848 chr16:68573721 ZFP90 0.46 5.79 0.3 1.65e-8 Ulcerative colitis; LUSC cis rs5758659 1.000 rs134882 chr22:42670965 A/G cg05082376 chr22:42548792 NA -0.37 -6.27 -0.32 1.11e-9 Cognitive function; LUSC cis rs3770081 1.000 rs2012798 chr2:86182756 T/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.03 -6.59 -0.34 1.67e-10 Facial emotion recognition (sad faces); LUSC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg22800045 chr5:56110881 MAP3K1 -0.74 -9.68 -0.47 1.11e-19 Initial pursuit acceleration; LUSC cis rs7103648 0.630 rs7934481 chr11:47883337 C/T cg20307385 chr11:47447363 PSMC3 0.8 12.26 0.56 8.59e-29 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs6076065 0.723 rs2236022 chr20:23373534 G/A cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg27170947 chr2:26402098 FAM59B -0.69 -10.55 -0.5 1.2e-22 Gut microbiome composition (summer); LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg08888203 chr3:10149979 C3orf24 0.59 8.23 0.41 4.19e-15 Alzheimer's disease; LUSC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg03929089 chr4:120376271 NA -0.52 -7.25 -0.37 2.92e-12 Coronary artery disease; LUSC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg18512352 chr11:47633146 NA 0.48 10.02 0.48 7.95e-21 Subjective well-being; LUSC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg25427524 chr10:38739819 LOC399744 -0.72 -13.51 -0.59 1.8e-33 Extrinsic epigenetic age acceleration; LUSC cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Bone mineral density; LUSC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg07636037 chr3:49044803 WDR6 1.05 18.89 0.72 1.18e-54 Parkinson's disease; LUSC cis rs968451 0.865 rs2007418 chr22:39712394 T/C cg17798944 chr22:39715225 SNORD43;RPL3 0.69 9.14 0.45 6.21e-18 Primary biliary cholangitis; LUSC cis rs7590368 0.961 rs2357815 chr2:10959769 C/T cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02708722 chr12:124118329 EIF2B1;GTF2H3 -0.4 -6.0 -0.31 5.23e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2229238 0.911 rs12405637 chr1:154501285 C/T cg25273160 chr11:56955011 LRRC55 0.32 6.11 0.32 2.82e-9 Coronary heart disease; LUSC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.78 -9.85 -0.47 2.91e-20 Gut microbiome composition (summer); LUSC cis rs11958404 0.932 rs6884954 chr5:157436772 C/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs6489882 0.902 rs3759376 chr12:113373563 A/G cg20102336 chr12:113376681 OAS3 -0.42 -6.03 -0.31 4.29e-9 Chronic lymphocytic leukemia; LUSC trans rs561341 1.000 rs542132 chr17:30307193 A/T cg27661571 chr11:113659931 NA -0.66 -7.8 -0.39 7.72e-14 Hip circumference adjusted for BMI; LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.54 6.72 0.35 7.95e-11 Renal function-related traits (BUN); LUSC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg21724239 chr8:58056113 NA 0.79 9.74 0.47 6.95e-20 Developmental language disorder (linguistic errors); LUSC cis rs11971779 0.680 rs4732369 chr7:139069173 C/A cg23387468 chr7:139079360 LUC7L2 0.42 6.31 0.33 9.09e-10 Diisocyanate-induced asthma; LUSC cis rs9300255 0.544 rs1727309 chr12:123658258 A/G cg00376283 chr12:123451042 ABCB9 0.75 8.33 0.41 2.04e-15 Neutrophil percentage of white cells; LUSC trans rs710987 0.967 rs710991 chr5:3518510 G/T cg27629735 chr1:3556483 WDR8 -0.35 -6.01 -0.31 4.9e-9 Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis; LUSC cis rs243505 0.691 rs243486 chr7:148448221 A/C cg09806900 chr7:148480153 CUL1 -0.54 -7.1 -0.36 7.78e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3768617 1.000 rs2027077 chr1:183073453 G/C ch.1.3577855R chr1:183094577 LAMC1 0.6 8.49 0.42 6.65e-16 Fuchs's corneal dystrophy; LUSC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.43 0.5 2.99e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg22455342 chr2:225449267 CUL3 -0.72 -9.65 -0.47 1.31e-19 IgE levels in asthmatics (D.p. specific); LUSC cis rs6920965 0.507 rs9385388 chr6:126215296 C/T cg10911889 chr6:126070802 HEY2 0.39 5.78 0.3 1.73e-8 High light scatter reticulocyte count; LUSC cis rs2762353 0.935 rs3799340 chr6:25762646 C/T cg03517284 chr6:25882590 NA 0.45 7.83 0.39 6.42e-14 Blood metabolite levels; LUSC trans rs72674100 1.000 rs28496290 chr4:97969761 G/T cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7605827 0.897 rs13004112 chr2:15604048 C/T cg19274914 chr2:15703543 NA 0.46 8.74 0.43 1.16e-16 Educational attainment (years of education); LUSC cis rs4919687 0.550 rs10437480 chr10:104453024 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -5.94 -0.31 7.19e-9 Colorectal cancer; LUSC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg04546413 chr19:29218101 NA 0.57 7.82 0.39 6.88e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7829975 0.846 rs11779061 chr8:8549432 G/A cg14343924 chr8:8086146 FLJ10661 -0.41 -5.65 -0.3 3.51e-8 Mood instability; LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg16405210 chr4:1374714 KIAA1530 -0.54 -8.23 -0.41 4.36e-15 Obesity-related traits; LUSC cis rs939658 0.805 rs35230534 chr15:79441093 T/C cg17916960 chr15:79447300 NA -0.53 -10.55 -0.5 1.24e-22 Refractive error; LUSC cis rs6977940 0.512 rs11765726 chr7:2850878 A/G cg19731401 chr7:2775893 GNA12 0.69 9.8 0.47 4.31e-20 White matter integrity; LUSC cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg05283184 chr6:79620031 NA -0.57 -11.95 -0.55 1.16e-27 Intelligence (multi-trait analysis); LUSC cis rs6087990 0.584 rs6058897 chr20:31398105 G/T cg13636640 chr20:31349939 DNMT3B -0.85 -16.5 -0.67 3.91e-45 Ulcerative colitis; LUSC cis rs7727544 0.508 rs10900804 chr5:131401845 C/T cg14196790 chr5:131705035 SLC22A5 0.48 7.81 0.39 7.39e-14 Blood metabolite levels; LUSC cis rs3820928 0.605 rs6748311 chr2:227792530 T/A cg11843606 chr2:227700838 RHBDD1 -0.65 -10.17 -0.49 2.38e-21 Pulmonary function; LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs72781680 0.948 rs72790326 chr2:24126153 C/T cg20701182 chr2:24300061 SF3B14 0.57 6.17 0.32 1.99e-9 Lymphocyte counts; LUSC cis rs17641971 0.599 rs818555 chr8:49999211 A/G cg00325661 chr8:49890786 NA -0.56 -9.37 -0.46 1.1e-18 Blood metabolite levels; LUSC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg14500267 chr11:67383377 NA -0.3 -5.68 -0.3 2.96e-8 Mean corpuscular volume; LUSC cis rs3784262 1.000 rs12910113 chr15:58248373 A/C cg12031962 chr15:58353849 ALDH1A2 -0.33 -6.09 -0.32 3.1e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg06484146 chr7:12443880 VWDE -0.69 -7.35 -0.37 1.53e-12 Coronary artery disease; LUSC trans rs3733585 0.673 rs10000983 chr4:9951606 T/C cg26043149 chr18:55253948 FECH -0.43 -6.6 -0.34 1.64e-10 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg03576123 chr11:487126 PTDSS2 -0.45 -5.81 -0.3 1.45e-8 Systemic lupus erythematosus; LUSC cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg01579765 chr21:45077557 HSF2BP -0.48 -9.94 -0.48 1.48e-20 Mean corpuscular volume; LUSC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg11366901 chr6:160182831 ACAT2 0.94 13.2 0.59 2.58e-32 Age-related macular degeneration (geographic atrophy); LUSC trans rs1864585 0.520 rs17776404 chr8:10672829 A/G cg26278703 chr11:58910052 FAM111A 0.56 6.29 0.33 9.69e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs4792901 0.802 rs72833136 chr17:41599690 G/A cg22562494 chr17:41607896 ETV4 -0.32 -5.95 -0.31 6.89e-9 Dupuytren's disease; LUSC cis rs7786877 0.626 rs11767547 chr7:100221635 C/T cg16850897 chr7:100343110 ZAN -0.47 -5.77 -0.3 1.79e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg20406979 chr6:167373233 NA -0.26 -6.22 -0.32 1.45e-9 Crohn's disease; LUSC cis rs10791097 0.694 rs7942621 chr11:130751308 C/G cg12179176 chr11:130786555 SNX19 0.86 15.14 0.64 8.3e-40 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06692871 chr8:101964133 YWHAZ -0.41 -6.27 -0.32 1.09e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9487051 0.768 rs463503 chr6:109525757 T/C cg01475377 chr6:109611718 NA -0.34 -5.8 -0.3 1.5e-8 Reticulocyte fraction of red cells; LUSC cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg13256891 chr4:100009986 ADH5 0.51 6.96 0.36 1.79e-11 Smoking initiation; LUSC cis rs7267979 0.833 rs6138556 chr20:25243310 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.3 0.67 2.26e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1568889 1.000 rs7949704 chr11:28373543 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 8.94 0.44 2.73e-17 Bipolar disorder; LUSC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg04369109 chr6:150039330 LATS1 0.53 7.79 0.39 8.34e-14 Lung cancer; LUSC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg02079420 chr8:82753780 SNX16 -0.43 -7.26 -0.37 2.67e-12 Diastolic blood pressure; LUSC cis rs9837602 1.000 rs6790877 chr3:99779658 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.17 0.32 2e-9 Breast cancer; LUSC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.63 -9.61 -0.47 1.89e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7833986 0.501 rs72653921 chr8:56897157 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.69 11.02 0.52 2.62e-24 Height; LUSC cis rs1538970 0.816 rs34673142 chr1:45985561 G/A cg05343316 chr1:45956843 TESK2 0.72 9.67 0.47 1.18e-19 Platelet count; LUSC cis rs2067615 0.599 rs3759310 chr12:107166122 C/G cg19260189 chr12:106995001 RFX4 0.22 5.65 0.3 3.43e-8 Heart rate; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg12564285 chr5:131593104 PDLIM4 0.44 7.88 0.4 4.67e-14 Breast cancer; LUSC cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg15423357 chr2:25149977 NA 0.45 9.12 0.45 7.07e-18 Body mass index in non-asthmatics; LUSC cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.53 -0.42 5.32e-16 Body mass index; LUSC trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg20587970 chr11:113659929 NA -1.31 -18.22 -0.71 5.26e-52 Hip circumference adjusted for BMI; LUSC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg23630131 chr7:65973040 NA -0.21 -5.82 -0.3 1.38e-8 Aortic root size; LUSC cis rs804280 0.525 rs1004712 chr8:11622293 C/T cg26752888 chr8:11627280 NEIL2 -0.43 -5.9 -0.31 8.7e-9 Myopia (pathological); LUSC cis rs11098499 0.774 rs73842616 chr4:120290683 G/A cg09307838 chr4:120376055 NA 0.69 10.35 0.49 5.71e-22 Corneal astigmatism; LUSC cis rs12410462 0.681 rs58496521 chr1:227582375 T/C cg23173402 chr1:227635558 NA 0.56 6.39 0.33 5.47e-10 Major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01399255 chr7:100271274 GNB2 -0.48 -6.03 -0.31 4.27e-9 Bipolar disorder and schizophrenia; LUSC cis rs12594515 1.000 rs8039622 chr15:45986431 A/G cg01629716 chr15:45996671 NA 0.4 6.01 0.31 4.9e-9 Waist circumference;Weight; LUSC cis rs7481584 0.624 rs421196 chr11:3048582 T/G cg25174290 chr11:3078921 CARS -0.41 -6.15 -0.32 2.22e-9 Calcium levels; LUSC cis rs7903847 0.642 rs9888117 chr10:99159963 C/G cg20016023 chr10:99160130 RRP12 -0.29 -7.34 -0.37 1.6e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg12292205 chr6:26970375 C6orf41 0.5 8.2 0.41 5.09e-15 Schizophrenia; LUSC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.67 0.47 1.2e-19 Height; LUSC cis rs9399135 0.967 rs4895439 chr6:135318854 A/T cg22676075 chr6:135203613 NA 0.48 7.48 0.38 6.5e-13 Red blood cell count; LUSC cis rs1371867 0.875 rs1788168 chr8:101324960 G/T cg06636551 chr8:101224915 SPAG1 -0.4 -7.47 -0.38 7.09e-13 Atrioventricular conduction; LUSC cis rs2720460 0.502 rs223374 chr4:103758301 T/C cg16532752 chr4:104119610 CENPE -0.42 -5.81 -0.3 1.46e-8 Testicular germ cell tumor; LUSC cis rs921968 0.509 rs556468 chr2:219355794 G/A cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs4595586 0.525 rs11613788 chr12:39390710 T/C cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg16928487 chr17:17741425 SREBF1 -0.42 -8.26 -0.41 3.35e-15 Total body bone mineral density; LUSC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg06740227 chr12:86229804 RASSF9 0.44 7.07 0.36 9.33e-12 Major depressive disorder; LUSC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.97 -0.36 1.74e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs8060686 0.641 rs8058690 chr16:68136622 T/G cg04539111 chr16:67997858 SLC12A4 -0.42 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs6977660 0.943 rs10254261 chr7:19846001 A/G cg07541023 chr7:19748670 TWISTNB -0.51 -5.91 -0.31 8.58e-9 Thyroid stimulating hormone; LUSC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg00810483 chr4:3375144 RGS12 0.31 5.94 0.31 7.34e-9 Serum sulfate level; LUSC cis rs7605827 0.897 rs6729018 chr2:15540676 A/G cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs11098499 0.775 rs10029303 chr4:120286755 T/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs7705502 0.962 rs55946741 chr5:173345023 A/G cg18693985 chr5:173351052 CPEB4 -0.36 -5.7 -0.3 2.66e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg07507251 chr3:52567010 NT5DC2 0.43 9.21 0.45 3.62e-18 Electroencephalogram traits; LUSC cis rs6541297 1.000 rs6665367 chr1:230279169 G/A cg05784532 chr1:230284198 GALNT2 0.49 7.39 0.38 1.16e-12 Coronary artery disease; LUSC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg15556689 chr8:8085844 FLJ10661 0.68 11.4 0.53 1.22e-25 Mood instability; LUSC cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg23583168 chr7:148888333 NA -0.92 -17.33 -0.69 1.88e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6752107 0.935 rs11690131 chr2:234148383 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 10.76 0.51 2.28e-23 Crohn's disease;Inflammatory bowel disease; LUSC cis rs477692 0.655 rs7906680 chr10:131442671 C/G cg05714579 chr10:131428358 MGMT -0.65 -10.51 -0.5 1.68e-22 Response to temozolomide; LUSC trans rs3774749 0.565 rs2518795 chr3:50208819 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.43 6.48 0.33 3.25e-10 Intelligence (multi-trait analysis); LUSC cis rs11250098 0.574 rs4240672 chr8:10767917 G/A cg21775007 chr8:11205619 TDH -0.49 -6.67 -0.34 1.06e-10 Morning vs. evening chronotype; LUSC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg17385448 chr1:15911702 AGMAT 0.35 5.94 0.31 7.3e-9 Systolic blood pressure; LUSC cis rs679087 1.000 rs672107 chr12:29917266 T/A cg14258853 chr12:29935411 TMTC1 -0.98 -16.21 -0.66 5.08e-44 Schizophrenia; LUSC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg07061783 chr6:25882402 NA -0.38 -6.1 -0.32 2.94e-9 Blood metabolite levels; LUSC cis rs2249625 0.526 rs17725666 chr6:72889711 G/A cg18830697 chr6:72922368 RIMS1 0.37 7.33 0.37 1.79e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg25204440 chr1:209979598 IRF6 0.68 11.75 0.54 6.28e-27 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg04586622 chr2:25135609 ADCY3 -0.42 -9.12 -0.45 7.16e-18 Body mass index; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.11 0.64 1.15e-39 Platelet count; LUSC cis rs77972916 0.505 rs6753197 chr2:43527962 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.47 -5.74 -0.3 2.12e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg06873352 chr17:61820015 STRADA 0.7 12.62 0.57 4.03e-30 Prudent dietary pattern; LUSC cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.51 -7.13 -0.36 6.11e-12 Tuberculosis; LUSC cis rs9389248 0.500 rs116273677 chr6:135339135 A/C cg24558204 chr6:135376177 HBS1L 0.59 9.09 0.45 8.72e-18 High light scatter reticulocyte percentage of red cells; LUSC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg13206674 chr6:150067644 NUP43 0.55 7.93 0.4 3.25e-14 Lung cancer; LUSC cis rs17270561 0.609 rs2154218 chr6:25776290 T/C cg16482183 chr6:26056742 HIST1H1C 0.56 7.79 0.39 8.37e-14 Iron status biomarkers; LUSC cis rs6693567 0.565 rs578353 chr1:150287884 C/G cg15654264 chr1:150340011 RPRD2 0.44 7.34 0.37 1.66e-12 Migraine; LUSC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs4588572 0.643 rs1019739 chr5:77770241 G/C cg11547950 chr5:77652471 NA -0.55 -7.69 -0.39 1.62e-13 Triglycerides; LUSC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg20503657 chr10:835505 NA -1.22 -16.54 -0.67 2.67e-45 Eosinophil percentage of granulocytes; LUSC cis rs7843479 0.562 rs2127206 chr8:21786989 C/T cg17168535 chr8:21777572 XPO7 0.82 14.81 0.63 1.64e-38 Mean corpuscular volume; LUSC cis rs11608355 0.545 rs2302706 chr12:109894028 A/G cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.7 0.34 8.82e-11 Recombination measurement; LUSC cis rs67072384 1.000 rs7120605 chr11:72444615 A/G cg04827223 chr11:72435913 ARAP1 -0.82 -7.76 -0.39 1.04e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg26597838 chr10:835615 NA 1.23 16.47 0.67 4.98e-45 Eosinophil percentage of granulocytes; LUSC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg05776053 chr2:74358815 NA 0.45 7.22 0.37 3.62e-12 Gestational age at birth (maternal effect); LUSC cis rs2708977 0.965 rs12717781 chr2:97249142 G/A cg01950434 chr2:97203154 ARID5A 0.57 8.7 0.43 1.57e-16 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg20503657 chr10:835505 NA 0.78 9.56 0.46 2.76e-19 Eosinophil percentage of granulocytes; LUSC cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg12219531 chr12:120966889 COQ5 0.6 8.02 0.4 1.85e-14 High light scatter reticulocyte count; LUSC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg17971929 chr21:40555470 PSMG1 0.79 13.75 0.6 2.1e-34 Cognitive function; LUSC cis rs7172677 0.691 rs12901092 chr15:75374145 C/A cg14664628 chr15:75095509 CSK 0.43 6.06 0.31 3.62e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg12311346 chr5:56204834 C5orf35 0.95 13.78 0.6 1.67e-34 Initial pursuit acceleration; LUSC cis rs4959270 0.967 rs4246068 chr6:457987 G/A cg09757644 chr6:447497 NA 0.29 5.9 0.31 8.86e-9 Limited cutaneous systemic scleroderma; LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg24503407 chr1:205819492 PM20D1 0.56 9.32 0.45 1.63e-18 Menarche (age at onset); LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg00166722 chr3:10149974 C3orf24 0.59 8.16 0.41 6.95e-15 Alzheimer's disease; LUSC trans rs7947523 0.813 rs4999940 chr11:80942337 C/T cg22345647 chr11:68609526 CPT1A -0.38 -5.98 -0.31 5.66e-9 Emphysema imaging phenotypes; LUSC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg19077165 chr18:44547161 KATNAL2 -0.4 -5.94 -0.31 7.06e-9 Personality dimensions; LUSC trans rs9951602 0.512 rs7241419 chr18:76640778 C/G cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg11366901 chr6:160182831 ACAT2 0.93 13.07 0.58 8.42e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg15423357 chr2:25149977 NA 0.44 8.98 0.44 1.96e-17 Body mass index; LUSC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg03929089 chr4:120376271 NA -1.04 -20.32 -0.74 2.6e-60 Height; LUSC cis rs17604090 1.000 rs17661896 chr7:29692708 G/A cg19413766 chr7:29689036 LOC646762 -0.62 -7.46 -0.38 7.31e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs4555082 1.000 rs4277291 chr14:105759009 A/G cg06808227 chr14:105710500 BRF1 -0.63 -9.69 -0.47 9.62e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -8.49 -0.42 7.07e-16 Lymphocyte counts; LUSC cis rs826838 0.935 rs4583043 chr12:38645147 T/G cg26384229 chr12:38710491 ALG10B 0.96 17.13 0.68 1.23e-47 Heart rate; LUSC trans rs1949829 0.826 rs57295596 chr7:51543037 G/T cg20941110 chr15:83953819 BNC1 0.56 6.06 0.31 3.58e-9 Wegener's granulomatosis; LUSC cis rs3862030 0.720 rs11191295 chr10:104231054 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.97 -0.44 2.18e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs4650994 0.525 rs2761463 chr1:178557137 T/C cg05059571 chr16:84539110 KIAA1609 0.48 9.16 0.45 5.47e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg11062466 chr8:58055876 NA 0.64 8.49 0.42 7.06e-16 Developmental language disorder (linguistic errors); LUSC trans rs45509595 0.749 rs401763 chr6:27782528 T/C cg01620082 chr3:125678407 NA -0.69 -7.05 -0.36 1.06e-11 Breast cancer; LUSC cis rs13385 0.769 rs7726349 chr5:139537771 C/T cg26211634 chr5:139558579 C5orf32 0.41 5.98 0.31 5.76e-9 Atrial fibrillation; LUSC cis rs7945705 0.846 rs4929912 chr11:8816695 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.53 -10.49 -0.5 1.88e-22 Hemoglobin concentration; LUSC cis rs6087990 0.836 rs2424909 chr20:31361861 T/C cg13636640 chr20:31349939 DNMT3B 0.99 21.69 0.76 9.62e-66 Ulcerative colitis; LUSC cis rs7819412 0.540 rs11777355 chr8:11044689 A/G cg21775007 chr8:11205619 TDH -0.47 -6.47 -0.33 3.45e-10 Triglycerides; LUSC cis rs1003719 0.715 rs2835640 chr21:38537380 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.56e-22 Eye color traits; LUSC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg18477163 chr1:228402036 OBSCN 0.62 12.2 0.56 1.49e-28 Diastolic blood pressure; LUSC cis rs7296418 0.922 rs1790134 chr12:123697898 T/C cg05973401 chr12:123451056 ABCB9 0.59 8.6 0.43 3.17e-16 Platelet count; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.67 0.34 1.09e-10 Obesity-related traits; LUSC trans rs853679 1.000 rs6901575 chr6:28250984 G/A cg01620082 chr3:125678407 NA -0.53 -6.35 -0.33 7.07e-10 Depression; LUSC cis rs9837602 1.000 rs7620228 chr3:99790332 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -5.99 -0.31 5.48e-9 Breast cancer; LUSC cis rs12410462 0.681 rs4486420 chr1:227572321 T/A cg04117972 chr1:227635322 NA 0.61 6.54 0.34 2.3e-10 Major depressive disorder; LUSC cis rs34421088 0.560 rs1478898 chr8:11395079 G/A cg21775007 chr8:11205619 TDH -0.53 -7.86 -0.39 5.44e-14 Neuroticism; LUSC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg06484146 chr7:12443880 VWDE -0.74 -7.32 -0.37 1.86e-12 Coronary artery disease; LUSC cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg06462663 chr19:18546047 ISYNA1 0.49 8.25 0.41 3.58e-15 Breast cancer; LUSC cis rs936229 0.749 rs8042694 chr15:75225415 G/A cg14664628 chr15:75095509 CSK -0.79 -11.67 -0.54 1.3e-26 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs8060686 0.545 rs3815173 chr16:68160289 T/G cg05110241 chr16:68378359 PRMT7 -0.64 -6.74 -0.35 6.99e-11 HDL cholesterol;Metabolic syndrome; LUSC trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.62 -0.38 2.63e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs7124681 0.584 rs11039448 chr11:47918416 G/T cg20307385 chr11:47447363 PSMC3 -0.52 -7.71 -0.39 1.41e-13 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs2777491 0.574 rs316611 chr15:41751678 A/G cg18705301 chr15:41695430 NDUFAF1 1.04 21.8 0.77 3.7e-66 Ulcerative colitis; LUSC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg07343612 chr16:622815 PIGQ -0.72 -12.2 -0.56 1.47e-28 Height; LUSC cis rs6961069 0.749 rs1537477 chr7:80251202 A/C cg04458919 chr7:80252533 CD36 0.36 6.47 0.33 3.43e-10 Platelet count; LUSC cis rs7909074 1.000 rs4948927 chr10:45397071 G/A cg04218760 chr10:45406644 TMEM72 -0.3 -7.24 -0.37 3.14e-12 Mean corpuscular volume; LUSC cis rs9303280 0.934 rs56380902 chr17:38066372 T/C cg19468946 chr17:37922297 IKZF3 -0.36 -5.65 -0.3 3.38e-8 Self-reported allergy; LUSC cis rs2204008 0.623 rs4882302 chr12:38415608 T/A cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.78e-15 Bladder cancer; LUSC trans rs1005277 0.579 rs2505241 chr10:38442421 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.59 -0.46 2.1e-19 Extrinsic epigenetic age acceleration; LUSC cis rs939574 1.000 rs2071385 chr2:220118782 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.09 8.89 0.44 3.98e-17 Platelet distribution width; LUSC cis rs9311676 0.656 rs7647184 chr3:58370046 C/T cg13750441 chr3:58318267 PXK 0.35 6.7 0.34 8.72e-11 Systemic lupus erythematosus; LUSC trans rs1493916 1.000 rs12457802 chr18:31389865 A/G cg13755796 chr4:20253514 NA 0.41 6.22 0.32 1.47e-9 Life satisfaction; LUSC cis rs1843834 0.858 rs2047136 chr2:225511361 A/T cg22455342 chr2:225449267 CUL3 0.44 6.05 0.31 3.88e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs2969070 0.965 rs9691234 chr7:2508415 A/G cg03277898 chr7:2518824 NA -0.27 -5.74 -0.3 2.18e-8 Diastolic blood pressure; LUSC cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.77 0.35 5.64e-11 Rheumatoid arthritis; LUSC cis rs2439831 0.850 rs11856795 chr15:44160582 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.74 6.54 0.34 2.33e-10 Lung cancer in ever smokers; LUSC trans rs12043259 1.000 rs12043259 chr1:204828041 C/G cg23865240 chr7:27134109 HOXA1 0.53 6.04 0.31 4.09e-9 Addiction; LUSC cis rs7647973 1.000 rs11130190 chr3:49402137 T/C cg07636037 chr3:49044803 WDR6 0.69 9.2 0.45 4.05e-18 Menarche (age at onset); LUSC cis rs7267979 0.816 rs443009 chr20:25499817 A/G cg03522245 chr20:25566470 NINL -0.36 -5.88 -0.31 1.01e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg22920501 chr2:26401640 FAM59B -0.75 -10.68 -0.5 4.33e-23 Gut microbiome composition (summer); LUSC cis rs6495367 1.000 rs1007365 chr15:79379492 T/G cg17916960 chr15:79447300 NA 0.37 6.96 0.36 1.79e-11 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6503863 1 rs6503863 chr17:56517034 G/A cg12560992 chr17:57184187 TRIM37 0.52 7.91 0.4 3.86e-14 Intelligence (multi-trait analysis); LUSC cis rs208520 0.955 rs12204033 chr6:67001525 T/C cg07460842 chr6:66804631 NA 0.83 10.18 0.49 2.15e-21 Exhaled nitric oxide output; LUSC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg03806693 chr22:41940476 POLR3H 0.99 14.14 0.61 6.88e-36 Vitiligo; LUSC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg18827107 chr12:86230957 RASSF9 -0.44 -6.61 -0.34 1.55e-10 Major depressive disorder; LUSC trans rs11098499 1.000 rs13435802 chr4:120177960 A/T cg25214090 chr10:38739885 LOC399744 -0.43 -6.43 -0.33 4.31e-10 Corneal astigmatism; LUSC cis rs2290159 0.898 rs2290160 chr3:12633083 A/G cg23032965 chr3:12705835 RAF1 0.56 7.2 0.37 3.96e-12 Cholesterol, total; LUSC cis rs12410462 0.579 rs116423559 chr1:227575014 A/G cg10327440 chr1:227177885 CDC42BPA -0.63 -5.86 -0.31 1.08e-8 Major depressive disorder; LUSC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs8114671 0.869 rs1544047 chr20:33670753 T/C cg07148914 chr20:33460835 GGT7 -0.46 -6.74 -0.35 7.17e-11 Height; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg09177884 chr7:1199841 ZFAND2A -0.41 -5.65 -0.3 3.46e-8 Longevity;Endometriosis; LUSC trans rs7937682 0.921 rs688354 chr11:111438762 A/G cg18187862 chr3:45730750 SACM1L 0.58 7.3 0.37 2.12e-12 Primary sclerosing cholangitis; LUSC cis rs3858526 0.834 rs10769395 chr11:5979620 G/A cg05234568 chr11:5960015 NA -0.63 -8.96 -0.44 2.27e-17 DNA methylation (variation); LUSC cis rs9420 0.816 rs674094 chr11:57665336 A/C cg23127183 chr11:57508653 C11orf31 0.5 6.73 0.35 7.41e-11 Schizophrenia; LUSC cis rs6669008 1.000 rs6669008 chr1:114166561 A/G cg26035817 chr1:114414802 PTPN22 0.44 6.94 0.35 2.08e-11 Bacteremia; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg23034840 chr1:205782522 SLC41A1 -0.75 -12.84 -0.57 6.23e-31 Monocyte percentage of white cells; LUSC cis rs6060960 0.502 rs6057968 chr20:30082779 A/T cg21427119 chr20:30132790 HM13 -0.42 -6.13 -0.32 2.5e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1322512 0.917 rs1830642 chr6:152963826 A/G cg27316956 chr6:152958899 SYNE1 -0.37 -6.32 -0.33 8.6e-10 Tonometry; LUSC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg05973401 chr12:123451056 ABCB9 0.55 6.82 0.35 4.37e-11 Neutrophil percentage of white cells; LUSC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg14895029 chr7:2775587 GNA12 -0.39 -6.02 -0.31 4.64e-9 Height; LUSC trans rs61931739 0.500 rs7133447 chr12:34041901 A/G cg13010199 chr12:38710504 ALG10B 0.52 7.89 0.4 4.44e-14 Morning vs. evening chronotype; LUSC cis rs9300255 0.537 rs1618679 chr12:123650714 A/G cg00376283 chr12:123451042 ABCB9 0.67 8.42 0.42 1.1e-15 Neutrophil percentage of white cells; LUSC cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg12140854 chr5:148520817 ABLIM3 -0.39 -5.89 -0.31 9.55e-9 Breast cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08803129 chr18:33708920 SLC39A6;ELP2 -0.51 -6.64 -0.34 1.3e-10 Hepatitis; LUSC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg13798780 chr7:105162888 PUS7 0.6 6.46 0.33 3.61e-10 Bipolar disorder (body mass index interaction); LUSC cis rs7223966 1.000 rs11079509 chr17:61762148 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.83 0.35 4.07e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg14541582 chr5:601475 NA -0.37 -5.65 -0.3 3.43e-8 Lung disease severity in cystic fibrosis; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg13453750 chr1:205783389 SLC41A1 -0.3 -5.86 -0.31 1.11e-8 Menarche (age at onset); LUSC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.38 7.03 0.36 1.2e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg04944784 chr2:26401820 FAM59B -0.72 -9.88 -0.48 2.35e-20 Gut microbiome composition (summer); LUSC cis rs3770081 1.000 rs6750765 chr2:86300308 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.9 -6.46 -0.33 3.63e-10 Facial emotion recognition (sad faces); LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg18099408 chr3:52552593 STAB1 -0.38 -6.17 -0.32 1.92e-9 Bipolar disorder; LUSC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg19346786 chr7:2764209 NA -0.45 -7.83 -0.39 6.53e-14 Height; LUSC cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg24642439 chr20:33292090 TP53INP2 0.5 7.5 0.38 5.67e-13 Glomerular filtration rate (creatinine); LUSC cis rs354225 0.554 rs10166844 chr2:54798272 T/C cg26097391 chr2:54893211 SPTBN1 0.47 7.06 0.36 9.87e-12 Schizophrenia; LUSC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg01879757 chr17:41196368 BRCA1 -0.49 -7.8 -0.39 8.11e-14 Menopause (age at onset); LUSC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg11812906 chr14:75593930 NEK9 -0.63 -10.52 -0.5 1.56e-22 Height; LUSC cis rs3768617 0.528 rs3736888 chr1:183084607 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05225062 chr19:13227642 TRMT1;NACC1 -0.41 -6.05 -0.31 3.99e-9 Electrocardiographic conduction measures; LUSC cis rs7122539 0.506 rs11227625 chr11:66684151 T/G cg24851651 chr11:66362959 CCS 0.45 7.73 0.39 1.24e-13 HIV-1 susceptibility; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg09704166 chr2:114031854 PAX8;LOC440839 -0.57 -9.6 -0.47 1.97e-19 Lymphocyte counts; LUSC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg00074818 chr8:8560427 CLDN23 0.57 9.71 0.47 8.22e-20 Obesity-related traits; LUSC cis rs7075426 0.669 rs10887608 chr10:88191938 A/G cg07322936 chr10:88137208 NA -0.44 -6.2 -0.32 1.69e-9 Migraine without aura; LUSC cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg11266682 chr4:10021025 SLC2A9 0.56 10.39 0.49 4.42e-22 Bone mineral density; LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.15 -0.58 4.15e-32 Platelet count; LUSC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg09034736 chr1:150693464 HORMAD1 0.52 7.61 0.38 2.77e-13 Tonsillectomy; LUSC cis rs243505 0.660 rs10274535 chr7:148543525 A/G cg09806900 chr7:148480153 CUL1 0.48 6.4 0.33 5.15e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs593982 0.843 rs565267 chr11:65473597 T/C cg08755490 chr11:65554678 OVOL1 1.52 12.84 0.57 6.01e-31 Atopic dermatitis; LUSC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 7.8 0.39 8.15e-14 Breast cancer; LUSC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg22105103 chr4:187893119 NA 0.71 13.88 0.6 6.72e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs9815354 1.000 rs9815354 chr3:41912651 G/A cg03022575 chr3:42003672 ULK4 0.58 6.24 0.32 1.33e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg22166914 chr1:53195759 ZYG11B -0.55 -8.77 -0.43 9.2e-17 Monocyte count; LUSC cis rs8177179 0.565 rs4355280 chr3:133468425 A/G cg01448562 chr3:133502909 NA -0.51 -8.0 -0.4 2.09e-14 Iron status biomarkers (transferrin levels); LUSC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.96e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC cis rs12286929 0.515 rs6589486 chr11:115084297 T/C cg04055981 chr11:115044050 NA 0.36 6.4 0.33 5.12e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs117623576 0.941 rs211424 chr10:32398895 A/G cg03047570 chr10:32398778 NA 0.68 7.53 0.38 4.72e-13 Anti-saccade response; LUSC cis rs68170813 0.617 rs76923959 chr7:107182915 T/C cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.67 0.39 1.88e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12410462 0.681 rs113316536 chr1:227547033 T/G cg04117972 chr1:227635322 NA 0.6 6.68 0.34 1e-10 Major depressive disorder; LUSC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg03161606 chr19:29218774 NA 0.6 8.89 0.44 4.03e-17 Methadone dose in opioid dependence; LUSC cis rs3809566 0.526 rs35829897 chr15:63334688 G/C cg00520135 chr15:63333846 TPM1 0.35 5.89 0.31 9.56e-9 Platelet count; LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg18876405 chr7:65276391 NA 0.53 8.5 0.42 6.2e-16 Calcium levels; LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg13560548 chr3:10150139 C3orf24 0.5 6.66 0.34 1.1e-10 Alzheimer's disease; LUSC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.79 -10.17 -0.49 2.34e-21 Ankle injury; LUSC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg13722127 chr7:150037890 RARRES2 0.38 5.68 0.3 3e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs7647973 0.559 rs9586 chr3:49213637 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.41 5.85 0.3 1.15e-8 Menarche (age at onset); LUSC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs35079168 0.809 rs11103483 chr9:137287874 G/A cg13941235 chr9:137270186 RXRA -0.32 -5.7 -0.3 2.66e-8 Intelligence; LUSC cis rs765787 0.530 rs4775844 chr15:45542048 T/C cg25801113 chr15:45476975 SHF 0.34 7.04 0.36 1.13e-11 Uric acid levels; LUSC trans rs11700980 0.551 rs2832027 chr21:30114365 C/T cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg23711669 chr6:146136114 FBXO30 0.82 14.02 0.61 2e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg05535760 chr7:792225 HEATR2 0.8 9.37 0.46 1.14e-18 Cerebrospinal P-tau181p levels; LUSC trans rs629535 0.954 rs559245 chr8:70009238 T/A cg21567404 chr3:27674614 NA -0.86 -13.02 -0.58 1.24e-31 Dupuytren's disease; LUSC cis rs72781680 1.000 rs12616985 chr2:24165511 A/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg09537434 chr19:41945824 ATP5SL -0.59 -7.82 -0.39 7.13e-14 Colorectal cancer; LUSC cis rs12681288 0.676 rs935820 chr8:1022168 A/G cg15309053 chr8:964076 NA 0.3 6.19 0.32 1.75e-9 Schizophrenia; LUSC cis rs4474465 0.646 rs10751297 chr11:78278567 C/T cg27205649 chr11:78285834 NARS2 0.54 6.7 0.34 8.92e-11 Alzheimer's disease (survival time); LUSC cis rs965469 0.947 rs1854834 chr20:3376619 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -5.8 -0.3 1.53e-8 IFN-related cytopenia; LUSC cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.39e-12 Motion sickness; LUSC cis rs7929679 0.551 rs11032840 chr11:34779464 G/T cg06937548 chr11:34938143 PDHX;APIP 0.4 5.83 0.3 1.32e-8 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 6.2 0.32 1.63e-9 Calcium levels; LUSC cis rs9517320 1.000 rs9584857 chr13:99128572 T/C cg07423050 chr13:99094983 FARP1 0.34 6.32 0.33 8.56e-10 Longevity; LUSC cis rs1981331 0.867 rs76188425 chr21:48002207 C/T cg17243659 chr21:48055224 PRMT2 0.86 6.24 0.32 1.31e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs9473147 0.516 rs9296561 chr6:47488938 G/A cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs8072100 0.817 rs11869940 chr17:45578435 T/A cg08085267 chr17:45401833 C17orf57 0.53 8.54 0.42 4.97e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6500602 0.727 rs2160567 chr16:4535557 C/T cg08645402 chr16:4508243 NA 0.48 8.09 0.4 1.11e-14 Schizophrenia; LUSC cis rs66731853 0.557 rs576968 chr1:20901246 A/G cg04087271 chr1:20915334 CDA -0.5 -8.86 -0.44 4.77e-17 Mean corpuscular volume; LUSC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.9 -0.35 2.62e-11 Total body bone mineral density; LUSC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg13798780 chr7:105162888 PUS7 0.58 6.26 0.32 1.21e-9 Bipolar disorder (body mass index interaction); LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg07092213 chr7:1199455 ZFAND2A -0.42 -6.7 -0.34 8.91e-11 Longevity;Endometriosis; LUSC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg04025307 chr7:1156635 C7orf50 0.47 6.25 0.32 1.26e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg22823121 chr1:150693482 HORMAD1 0.57 8.85 0.44 5.08e-17 Tonsillectomy; LUSC cis rs9527 0.590 rs3781282 chr10:104852419 C/T cg04362960 chr10:104952993 NT5C2 -0.59 -9.38 -0.46 1.05e-18 Arsenic metabolism; LUSC cis rs6582630 0.576 rs2387836 chr12:38560070 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.59 0.34 1.7e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs62432291 0.614 rs452112 chr6:159658028 A/G cg14500486 chr6:159655392 FNDC1 -0.52 -5.7 -0.3 2.67e-8 Joint mobility (Beighton score); LUSC trans rs208520 0.674 rs207103 chr6:66795568 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC trans rs61931739 0.500 rs7307583 chr12:34521711 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.09 0.45 9.21e-18 Morning vs. evening chronotype; LUSC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg23743428 chr13:21893420 NA -0.44 -8.83 -0.44 5.93e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs11997175 1.000 rs6468201 chr8:33746854 G/C ch.8.33884649F chr8:33765107 NA 0.52 8.24 0.41 3.91e-15 Body mass index; LUSC cis rs7216064 1.000 rs6504543 chr17:65837659 T/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.59 -0.46 2.17e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17650050 chr22:19419470 HIRA;MRPL40 0.74 6.02 0.31 4.6e-9 Cognitive performance; LUSC trans rs61931739 0.534 rs4086956 chr12:34105047 A/T cg13010199 chr12:38710504 ALG10B 0.54 8.05 0.4 1.48e-14 Morning vs. evening chronotype; LUSC trans rs877282 0.945 rs11253391 chr10:788752 G/A cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg11057378 chr10:81107060 PPIF 0.35 5.96 0.31 6.33e-9 Height; LUSC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg16339924 chr4:17578868 LAP3 0.55 8.38 0.42 1.46e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs11098499 0.863 rs6858777 chr4:120475966 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC trans rs911555 0.692 rs7140647 chr14:103893465 A/G cg17675199 chr6:35436792 RPL10A -0.42 -6.22 -0.32 1.5e-9 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg08847533 chr14:75593920 NEK9 0.84 15.33 0.64 1.54e-40 Height; LUSC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs9467711 0.591 rs35335639 chr6:26038681 C/G cg16898833 chr6:26189333 HIST1H4D 0.62 5.84 0.3 1.24e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs11971779 0.616 rs1862878 chr7:139019914 C/G cg07862535 chr7:139043722 LUC7L2 0.55 6.81 0.35 4.45e-11 Diisocyanate-induced asthma; LUSC cis rs6918586 0.615 rs198841 chr6:26111671 G/T cg17691542 chr6:26056736 HIST1H1C 0.4 5.87 0.31 1.03e-8 Schizophrenia; LUSC cis rs4363385 0.818 rs10888526 chr1:153000311 G/T cg00922841 chr1:152955080 SPRR1A -0.45 -7.91 -0.4 3.94e-14 Inflammatory skin disease; LUSC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg09359103 chr1:154839909 KCNN3 -0.71 -16.49 -0.67 4.11e-45 Prostate cancer; LUSC trans rs16848425 1.000 rs28631242 chr4:73526282 T/A cg15289899 chr11:2397255 CD81 0.68 5.96 0.31 6.35e-9 Height; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18765753 chr7:1198926 ZFAND2A -0.63 -12.91 -0.58 3.21e-31 Longevity;Endometriosis; LUSC cis rs11190604 1.000 rs11190569 chr10:102227409 C/T cg16342193 chr10:102329863 NA -0.33 -6.13 -0.32 2.54e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg24324837 chr19:49891574 CCDC155 0.5 6.41 0.33 5.07e-10 Multiple sclerosis; LUSC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg27286337 chr10:134555280 INPP5A 0.93 12.01 0.55 6.99e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10089 1.000 rs4836361 chr5:127459991 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.72 0.54 8.34e-27 Ileal carcinoids; LUSC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg15605315 chr1:45957053 TESK2 -0.43 -6.81 -0.35 4.6e-11 High light scatter reticulocyte count; LUSC cis rs3771570 1.000 rs62193256 chr2:242362168 C/T cg21155796 chr2:242212141 HDLBP 0.62 6.69 0.34 9.6e-11 Prostate cancer; LUSC cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg08999081 chr20:33150536 PIGU 0.55 10.8 0.51 1.66e-23 Coronary artery disease; LUSC cis rs9788682 0.633 rs2656070 chr15:78730252 A/G cg06917634 chr15:78832804 PSMA4 0.47 5.78 0.3 1.68e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1801251 1.000 rs895430 chr2:233725483 C/A cg25237894 chr2:233734115 C2orf82 -0.37 -6.92 -0.35 2.37e-11 Coronary artery disease; LUSC cis rs1950500 0.585 rs8003339 chr14:24817817 T/C cg16194253 chr14:24768981 DHRS1;C14orf21 0.56 8.9 0.44 3.58e-17 Height; LUSC cis rs524023 0.957 rs552307 chr11:64357539 G/A cg07220939 chr11:64358617 SLC22A12 0.23 6.0 0.31 5.01e-9 Urate levels in obese individuals; LUSC cis rs7833986 0.501 rs2953898 chr8:56980803 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.46 0.56 1.61e-29 Height; LUSC cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.86 0.47 2.66e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg11941060 chr3:133502564 NA -0.6 -9.47 -0.46 5.33e-19 Iron status biomarkers; LUSC cis rs3093024 0.595 rs4412174 chr6:167476066 A/G cg07741184 chr6:167504864 NA 0.49 8.55 0.42 4.42e-16 Rheumatoid arthritis; LUSC cis rs6456156 0.586 rs6909180 chr6:167460537 A/G cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs752010 0.645 rs1109254 chr1:42091770 T/C cg06885757 chr1:42089581 HIVEP3 0.62 12.79 0.57 9.53e-31 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.39 6.16 0.32 2.09e-9 Total body bone mineral density; LUSC cis rs3820928 0.874 rs10199655 chr2:227892428 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.55 -0.38 4.32e-13 Pulmonary function; LUSC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg02551604 chr5:131831745 NA -0.4 -6.27 -0.32 1.1e-9 Asthma (sex interaction); LUSC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg06145435 chr7:1022769 CYP2W1 0.35 5.77 0.3 1.82e-8 Bronchopulmonary dysplasia; LUSC cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 1.01 18.79 0.72 2.92e-54 Chronic sinus infection; LUSC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg11608241 chr8:8085544 FLJ10661 -0.4 -5.81 -0.3 1.44e-8 Mood instability; LUSC cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg06064525 chr11:970664 AP2A2 -0.49 -10.74 -0.51 2.59e-23 Alzheimer's disease (late onset); LUSC cis rs950169 0.922 rs12911223 chr15:84831671 G/A cg17507749 chr15:85114479 UBE2QP1 -0.67 -8.67 -0.43 1.96e-16 Schizophrenia; LUSC cis rs546131 0.890 rs496558 chr11:34826425 C/T cg06937548 chr11:34938143 PDHX;APIP 0.48 6.68 0.34 9.84e-11 Lung disease severity in cystic fibrosis; LUSC cis rs12618769 0.625 rs72819982 chr2:99043337 A/G cg10123293 chr2:99228465 UNC50 0.46 7.64 0.39 2.27e-13 Bipolar disorder; LUSC cis rs16937 0.711 rs11240382 chr1:205168569 A/G cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg03678062 chr6:149772716 ZC3H12D -0.31 -6.49 -0.33 3.02e-10 Dupuytren's disease; LUSC cis rs4595586 0.525 rs4450203 chr12:39381493 T/G cg13010199 chr12:38710504 ALG10B 0.4 5.88 0.31 1.01e-8 Morning vs. evening chronotype; LUSC cis rs11098499 0.697 rs6832410 chr4:120296800 A/G cg24375607 chr4:120327624 NA 0.78 11.52 0.53 4.39e-26 Corneal astigmatism; LUSC trans rs1325195 0.537 rs2793808 chr1:179170249 T/C cg11624085 chr17:8464688 MYH10 0.43 6.38 0.33 5.94e-10 IgE grass sensitization; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16530077 chr14:50319734 SDCCAG1 0.46 6.51 0.34 2.84e-10 Triglycerides; LUSC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg10487724 chr17:56770010 TEX14;RAD51C -0.46 -7.13 -0.36 6.11e-12 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg21724239 chr8:58056113 NA 0.57 6.55 0.34 2.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg24642439 chr20:33292090 TP53INP2 -0.54 -8.33 -0.41 2.07e-15 Coronary artery disease; LUSC trans rs2204008 0.558 rs66545149 chr12:38204694 A/G cg06521331 chr12:34319734 NA -0.41 -6.13 -0.32 2.49e-9 Bladder cancer; LUSC cis rs12545109 0.800 rs2221919 chr8:57412541 A/C cg09654669 chr8:57350985 NA -0.58 -7.84 -0.39 5.98e-14 Obesity-related traits; LUSC cis rs7103648 0.567 rs12287076 chr11:47606865 G/C cg20307385 chr11:47447363 PSMC3 -0.81 -12.45 -0.56 1.71e-29 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs7605827 0.930 rs13004154 chr2:15664325 A/G cg19274914 chr2:15703543 NA 0.47 8.76 0.43 9.81e-17 Educational attainment (years of education); LUSC cis rs847577 0.587 rs34307903 chr7:97728449 C/A cg21770322 chr7:97807741 LMTK2 0.55 9.73 0.47 7.22e-20 Breast cancer; LUSC cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg26647111 chr11:31128758 NA -0.41 -5.98 -0.31 5.75e-9 Red blood cell count; LUSC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg10862848 chr6:42927986 GNMT 0.24 5.69 0.3 2.75e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.44 6.16 0.32 2.08e-9 Renal function-related traits (BUN); LUSC trans rs7824557 0.603 rs2250028 chr8:11213589 T/G cg08975724 chr8:8085496 FLJ10661 0.52 7.36 0.37 1.48e-12 Retinal vascular caliber; LUSC cis rs13088318 0.521 rs7374860 chr3:101223721 A/G cg12386194 chr3:101231763 SENP7 0.38 5.77 0.3 1.82e-8 Allergic disease (asthma, hay fever or eczema); LUSC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg11247378 chr22:39784982 NA -0.64 -11.76 -0.54 5.75e-27 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg25703541 chr22:24373054 LOC391322 -0.86 -13.14 -0.58 4.56e-32 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg15212455 chr7:39170539 POU6F2 0.68 11.64 0.54 1.63e-26 IgG glycosylation; LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg22907277 chr7:1156413 C7orf50 0.38 5.91 0.31 8.67e-9 Longevity;Endometriosis; LUSC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg20243544 chr17:37824526 PNMT 0.39 6.02 0.31 4.54e-9 Self-reported allergy; LUSC cis rs9393777 0.778 rs13212921 chr6:27205422 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -5.81 -0.3 1.49e-8 Intelligence (multi-trait analysis); LUSC cis rs35096708 1.000 rs35096708 chr16:89887249 G/A cg04287289 chr16:89883240 FANCA -0.5 -5.89 -0.31 9.66e-9 Skin aging (microtopography measurement); LUSC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg05340658 chr4:99064831 C4orf37 0.64 10.17 0.49 2.45e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9640161 0.830 rs17173702 chr7:150068605 G/A cg27494647 chr7:150038898 RARRES2 0.42 6.27 0.32 1.13e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs17270561 0.636 rs1185977 chr6:25829054 A/G cg17691542 chr6:26056736 HIST1H1C 0.49 6.95 0.36 1.97e-11 Iron status biomarkers; LUSC cis rs6088580 0.524 rs7274854 chr20:33228672 A/C cg08999081 chr20:33150536 PIGU 0.41 7.81 0.39 7.29e-14 Glomerular filtration rate (creatinine); LUSC cis rs2303282 0.716 rs2587871 chr16:56412526 C/T cg00500540 chr16:56394104 NA 0.45 7.88 0.4 4.68e-14 Breast cancer; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg09033563 chr22:24373618 LOC391322 -0.47 -6.59 -0.34 1.75e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9916302 0.706 rs4795358 chr17:37573065 A/C cg07936489 chr17:37558343 FBXL20 -0.8 -9.73 -0.47 7.14e-20 Glomerular filtration rate (creatinine); LUSC cis rs11190604 1.000 rs10883500 chr10:102238324 T/G cg16342193 chr10:102329863 NA -0.35 -6.32 -0.33 8.52e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7769051 1.000 rs6910639 chr6:133120553 A/G cg22852734 chr6:133119734 C6orf192 1.22 14.16 0.61 5.52e-36 Type 2 diabetes nephropathy; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.34 -0.42 1.94e-15 Lymphocyte counts; LUSC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg20406979 chr6:167373233 NA 0.25 5.96 0.31 6.39e-9 Crohn's disease; LUSC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg12863693 chr15:85201151 NMB 0.34 6.82 0.35 4.26e-11 Schizophrenia; LUSC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg26441486 chr22:50317300 CRELD2 0.48 7.1 0.36 7.5e-12 Schizophrenia; LUSC cis rs1023500 0.573 rs2413666 chr22:42459622 C/T cg04733989 chr22:42467013 NAGA 0.63 9.82 0.47 3.7799999999999997e-20 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21953508 chr4:38690502 KLF3 0.41 6.08 0.32 3.25e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs393155 0.517 rs330050 chr8:9087679 G/C cg27411982 chr8:10470053 RP1L1 -0.39 -6.09 -0.32 3.1e-9 Neuroticism; LUSC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg24209194 chr3:40518798 ZNF619 0.47 6.51 0.34 2.72e-10 Renal cell carcinoma; LUSC trans rs9693857 0.553 rs10100760 chr8:9370559 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.42 -0.33 4.71e-10 Systolic blood pressure; LUSC cis rs2290405 0.527 rs935965 chr4:928684 T/C cg04824913 chr4:887549 GAK 0.72 9.66 0.47 1.25e-19 Systemic sclerosis; LUSC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg17739936 chr11:789930 CEND1 0.38 6.45 0.33 3.86e-10 Breast cancer; LUSC cis rs617219 0.819 rs4704552 chr5:78580368 C/T cg24856658 chr5:78533917 JMY 0.31 6.14 0.32 2.36e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9393692 0.645 rs6939048 chr6:26327953 G/A cg13736514 chr6:26305472 NA -0.55 -10.81 -0.51 1.5e-23 Educational attainment; LUSC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.54 -0.38 4.33e-13 Blood metabolite levels; LUSC trans rs12579753 0.917 rs12316644 chr12:82205497 C/T cg07923666 chr12:49932857 KCNH3 0.48 6.09 0.32 3.03e-9 Resting heart rate; LUSC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg12501923 chr17:73937416 FBF1 0.46 8.17 0.41 6.58e-15 Triglycerides; LUSC cis rs6942756 0.747 rs692432 chr7:129113287 G/A cg02491457 chr7:128862824 NA -0.4 -5.65 -0.3 3.4e-8 White matter hyperintensity burden; LUSC cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg16339924 chr4:17578868 LAP3 0.56 8.5 0.42 6.45e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.34 0.56 4.55e-29 Prudent dietary pattern; LUSC cis rs10072221 0.966 rs11743541 chr5:75738858 A/G cg03132911 chr5:75698732 IQGAP2 -0.35 -5.71 -0.3 2.55e-8 Mean platelet volume; LUSC cis rs10189230 0.967 rs13012429 chr2:222350788 C/T cg14652038 chr2:222343519 EPHA4 0.33 5.93 0.31 7.56e-9 Urate levels in lean individuals; LUSC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg23649088 chr2:200775458 C2orf69 -0.58 -7.13 -0.36 6.36e-12 Schizophrenia; LUSC trans rs8073060 0.544 rs8072676 chr17:33999517 C/T cg19694781 chr19:47549865 TMEM160 -1.15 -18.16 -0.7 9.3e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1018836 0.818 rs715057 chr8:91624340 T/C cg16814680 chr8:91681699 NA -0.78 -13.29 -0.59 1.15e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4343996 0.692 rs1546742 chr7:3456210 C/A cg21248987 chr7:3385318 SDK1 0.35 5.75 0.3 2.03e-8 Motion sickness; LUSC cis rs4631830 0.869 rs7896437 chr10:51529593 A/C cg20129853 chr10:51489980 NA -0.33 -6.61 -0.34 1.55e-10 Prostate-specific antigen levels; LUSC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg27432699 chr2:27873401 GPN1 0.62 9.39 0.46 9.98e-19 Total body bone mineral density; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg24476096 chr1:43855459 MED8;C1orf84 0.37 5.97 0.31 5.98e-9 Metabolite levels (Pyroglutamine); LUSC cis rs7202877 0.610 rs3784936 chr16:75337583 C/G cg04384234 chr16:75411784 CFDP1 -0.6 -7.64 -0.39 2.37e-13 Type 2 diabetes;Type 1 diabetes; LUSC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg19230755 chr7:65878503 NA -0.42 -5.93 -0.31 7.69e-9 Aortic root size; LUSC cis rs4803468 1.000 rs2288871 chr19:41917868 C/T cg09537434 chr19:41945824 ATP5SL -0.91 -16.24 -0.66 4.18e-44 Height; LUSC cis rs4917300 0.626 rs1388796 chr8:143096437 A/G cg25363559 chr8:143086065 NA -0.31 -7.01 -0.36 1.35e-11 Amyotrophic lateral sclerosis; LUSC cis rs6752107 0.500 rs11893210 chr2:234204672 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.54 8.12 0.41 9.29e-15 Crohn's disease;Inflammatory bowel disease; LUSC cis rs742614 0.576 rs2747537 chr20:32405217 A/G cg06304546 chr20:32448765 NA -0.38 -5.8 -0.3 1.51e-8 Stearic acid (18:0) levels; LUSC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg11764359 chr7:65958608 NA -0.7 -10.62 -0.5 7.05e-23 Aortic root size; LUSC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.39 0.33 5.7e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 1.000 rs2500405 chr20:25360826 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9325144 0.602 rs11169100 chr12:39077861 G/T cg13010199 chr12:38710504 ALG10B -0.49 -7.43 -0.38 9.21e-13 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg18099408 chr3:52552593 STAB1 -0.41 -6.96 -0.36 1.84e-11 Bipolar disorder; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg24503407 chr1:205819492 PM20D1 0.9 16.95 0.68 6.11e-47 Menarche (age at onset); LUSC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.47 0.42 7.84e-16 Tonsillectomy; LUSC cis rs7903847 0.620 rs61863815 chr10:99124389 A/G cg20016023 chr10:99160130 RRP12 -0.34 -8.18 -0.41 5.86e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs2279817 0.675 rs1416853 chr1:18024880 G/C cg21791023 chr1:18019539 ARHGEF10L 0.5 7.27 0.37 2.55e-12 Neuroticism; LUSC cis rs6754311 0.593 rs656326 chr2:136428460 A/C cg07169764 chr2:136633963 MCM6 0.54 7.2 0.37 3.91e-12 Mosquito bite size; LUSC cis rs6429082 0.818 rs291344 chr1:235663860 C/G cg26050004 chr1:235667680 B3GALNT2 -0.58 -7.84 -0.39 6.09e-14 Adiposity; LUSC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.17 -0.32 2.01e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2288073 0.965 rs36101491 chr2:24387532 C/T cg06627628 chr2:24431161 ITSN2 -0.78 -10.77 -0.51 2.03e-23 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg05347473 chr6:146136440 FBXO30 0.41 6.84 0.35 3.78e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9807989 0.839 rs1362348 chr2:102984624 C/G cg09003973 chr2:102972529 NA 0.42 5.7 0.3 2.65e-8 Asthma; LUSC cis rs6500395 1.000 rs9922734 chr16:48603192 A/G cg04672837 chr16:48644449 N4BP1 -0.43 -6.38 -0.33 5.94e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9815354 1.000 rs9873207 chr3:41884750 C/T cg03022575 chr3:42003672 ULK4 0.64 7.02 0.36 1.21e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC cis rs9467773 0.649 rs2145318 chr6:26496603 T/A cg11502198 chr6:26597334 ABT1 0.57 8.43 0.42 1.07e-15 Intelligence (multi-trait analysis); LUSC cis rs10463316 0.817 rs6897109 chr5:150777738 T/C cg03212797 chr5:150827313 SLC36A1 -0.47 -7.2 -0.37 3.95e-12 Metabolite levels (Pyroglutamine); LUSC trans rs9467711 0.606 rs9348726 chr6:26605206 G/A cg06606381 chr12:133084897 FBRSL1 -0.68 -6.74 -0.35 7.03e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg23711669 chr6:146136114 FBXO30 0.92 18.09 0.7 1.86e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs7809950 0.598 rs2283038 chr7:106835410 C/T cg23024343 chr7:107201750 COG5 -0.62 -8.95 -0.44 2.5e-17 Coronary artery disease; LUSC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg05585544 chr11:47624801 NA -0.33 -5.99 -0.31 5.29e-9 Subjective well-being; LUSC cis rs4919694 1.000 rs78214351 chr10:104822688 A/G cg04362960 chr10:104952993 NT5C2 1.17 13.82 0.6 1.12e-34 Arsenic metabolism; LUSC cis rs34779708 0.897 rs4934527 chr10:35281118 T/A cg04310649 chr10:35416472 CREM -0.41 -6.22 -0.32 1.5e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7523050 0.730 rs7519107 chr1:109399367 A/C cg08274380 chr1:109419600 GPSM2 1.1 10.62 0.5 6.89e-23 Fat distribution (HIV); LUSC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs12478296 0.786 rs13409307 chr2:242995499 G/C cg06360820 chr2:242988706 NA -0.85 -10.14 -0.49 3.06e-21 Obesity-related traits; LUSC cis rs1355223 0.583 rs2941043 chr11:34870994 A/G cg24088639 chr11:34937564 PDHX;APIP 0.46 6.75 0.35 6.47e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs2468186 0.903 rs2468184 chr8:120197863 A/G cg15910414 chr5:137879246 ETF1 -0.42 -5.96 -0.31 6.28e-9 Osteoprotegerin levels; LUSC cis rs9929218 0.529 rs8060790 chr16:68729112 A/G cg01251360 chr16:68772225 CDH1 -0.27 -6.24 -0.32 1.34e-9 Colorectal cancer; LUSC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC cis rs4253772 0.744 rs1134224 chr22:46633371 A/T cg09491104 chr22:46646882 C22orf40 -0.61 -8.62 -0.43 2.7e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg00599273 chr12:58146742 CDK4 0.3 5.71 0.3 2.48e-8 Multiple sclerosis; LUSC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg18876405 chr7:65276391 NA 0.64 11.09 0.52 1.51e-24 Aortic root size; LUSC cis rs12681287 0.547 rs60982560 chr8:87515046 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.35 -0.37 1.52e-12 Caudate activity during reward; LUSC cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg18252515 chr7:66147081 NA -1.24 -13.99 -0.61 2.59e-35 Diabetic kidney disease; LUSC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC cis rs7582180 0.676 rs11680660 chr2:100931738 G/C cg12002119 chr2:101014098 CHST10 0.36 5.94 0.31 7.24e-9 Intelligence (multi-trait analysis); LUSC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs77106637 0.860 rs11603334 chr11:72432985 G/A cg03878208 chr11:72483293 STARD10 0.5 5.76 0.3 1.94e-8 Type 2 diabetes; LUSC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.35 -5.81 -0.3 1.49e-8 Total body bone mineral density; LUSC trans rs7746199 0.736 rs13195636 chr6:27509493 A/C cg06606381 chr12:133084897 FBRSL1 -0.97 -9.13 -0.45 6.87e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4363385 0.818 rs6661791 chr1:152994113 G/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.5 -0.38 5.84e-13 Inflammatory skin disease; LUSC cis rs10876993 0.622 rs7978394 chr12:58091695 C/A cg15848620 chr12:58087721 OS9 -0.57 -8.16 -0.41 6.96e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs611744 0.529 rs13282825 chr8:109263237 T/C cg21045802 chr8:109455806 TTC35 0.43 6.63 0.34 1.38e-10 Dupuytren's disease; LUSC cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg00277334 chr10:82204260 NA -0.94 -19.32 -0.73 2.36e-56 Post bronchodilator FEV1; LUSC trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg06636001 chr8:8085503 FLJ10661 0.52 7.28 0.37 2.45e-12 Neuroticism; LUSC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.62 0.47 1.66e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs61931739 0.500 rs10844844 chr12:34380350 G/T cg06521331 chr12:34319734 NA -0.41 -6.52 -0.34 2.61e-10 Morning vs. evening chronotype; LUSC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.69 10.13 0.48 3.34e-21 IgG glycosylation; LUSC trans rs11098499 0.820 rs11737395 chr4:120520704 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.98 0.36 1.64e-11 Corneal astigmatism; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg16145915 chr7:1198662 ZFAND2A -0.52 -9.47 -0.46 5.1e-19 Longevity;Endometriosis; LUSC cis rs13217239 0.608 rs6930508 chr6:27053142 T/C cg12292205 chr6:26970375 C6orf41 -0.5 -8.19 -0.41 5.49e-15 Schizophrenia; LUSC cis rs9788721 1.000 rs8031948 chr15:78816057 G/T cg18825076 chr15:78729989 IREB2 -0.5 -7.86 -0.4 5.24e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs7264396 1.000 rs224429 chr20:34152018 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -7.51 -0.38 5.32e-13 Total cholesterol levels; LUSC trans rs7824557 0.564 rs1435275 chr8:11235735 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.54 -0.34 2.27e-10 Retinal vascular caliber; LUSC trans rs10435719 0.867 rs62493601 chr8:11788307 C/T cg08975724 chr8:8085496 FLJ10661 0.49 7.05 0.36 1.05e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs79349575 0.715 rs4793997 chr17:47019672 C/A cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs17255340 0.539 rs1170514 chr6:84009042 T/C cg08257003 chr6:84140564 ME1 0.32 7.8 0.39 7.87e-14 Platelet-derived growth factor BB levels; LUSC cis rs8014204 0.804 rs2241274 chr14:75251331 G/A cg06637938 chr14:75390232 RPS6KL1 0.65 10.91 0.51 6.45e-24 Caffeine consumption; LUSC cis rs12824058 0.831 rs11608406 chr12:130805866 G/C cg26677194 chr12:130822605 PIWIL1 0.56 8.41 0.42 1.21e-15 Menopause (age at onset); LUSC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg04398451 chr17:18023971 MYO15A -0.44 -6.92 -0.35 2.29e-11 Total body bone mineral density; LUSC cis rs7809950 0.862 rs58391518 chr7:107030787 T/C cg23024343 chr7:107201750 COG5 -0.54 -8.39 -0.42 1.38e-15 Coronary artery disease; LUSC cis rs950027 0.620 rs2467862 chr15:45643843 T/G cg14582100 chr15:45693742 SPATA5L1 0.46 8.66 0.43 2.11e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs9486719 1.000 rs2499807 chr6:96864053 T/G cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs7809950 0.906 rs2253269 chr7:107201114 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.76 -0.43 9.82e-17 Coronary artery disease; LUSC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs6940638 0.688 rs9295730 chr6:27128806 T/C cg05738196 chr6:26577821 NA -0.49 -6.94 -0.36 2.01e-11 Intelligence (multi-trait analysis); LUSC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.93 14.88 0.63 9.31e-39 Multiple sclerosis; LUSC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg12463550 chr7:65579703 CRCP 0.42 5.96 0.31 6.27e-9 Aortic root size; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg02951883 chr7:2050386 MAD1L1 -0.45 -7.89 -0.4 4.47e-14 Bipolar disorder and schizophrenia; LUSC cis rs1568889 1.000 rs35697240 chr11:28287342 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 8.64 0.43 2.34e-16 Bipolar disorder; LUSC cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.12 0.32 2.58e-9 Rheumatoid arthritis; LUSC cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg25173405 chr17:45401733 C17orf57 -0.41 -6.58 -0.34 1.82e-10 Multiple sclerosis;Ankylosing spondylitis; LUSC cis rs709400 0.627 rs62007686 chr14:103899344 A/G cg12935359 chr14:103987150 CKB -0.57 -8.56 -0.42 4.26e-16 Body mass index; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.53 -8.11 -0.41 9.51e-15 Lymphocyte counts; LUSC trans rs2204008 0.837 rs2127955 chr12:37969194 A/G cg06521331 chr12:34319734 NA -0.39 -6.26 -0.32 1.18e-9 Bladder cancer; LUSC trans rs2834485 1.000 rs5010906 chr21:35818590 G/C cg07474852 chr4:123073612 NA 0.45 6.63 0.34 1.38e-10 Cancer; LUSC cis rs644799 0.511 rs12791736 chr11:95475399 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.53 7.27 0.37 2.61e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg03209412 chr4:183728196 NA 0.47 7.81 0.39 7.26e-14 Pediatric autoimmune diseases; LUSC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg02428538 chr16:24856791 SLC5A11 -0.55 -6.31 -0.33 8.98e-10 Intelligence (multi-trait analysis); LUSC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.8e-13 Schizophrenia; LUSC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg19774624 chr17:42201019 HDAC5 0.71 10.39 0.49 4.28e-22 Total body bone mineral density; LUSC trans rs7681440 0.904 rs28415623 chr4:90767110 C/T cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs9467773 0.620 rs2494700 chr6:26631306 C/T cg05738196 chr6:26577821 NA 0.78 14.95 0.63 4.82e-39 Intelligence (multi-trait analysis); LUSC cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg21466736 chr12:48725269 NA -0.33 -5.75 -0.3 2.06e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs11792861 0.890 rs3750465 chr9:111900677 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -7.78 -0.39 9.39e-14 Menarche (age at onset); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg21522636 chr3:50374980 RASSF1 0.44 6.23 0.32 1.39e-9 Calcium levels; LUSC cis rs6445967 0.530 rs62258104 chr3:58379984 G/C cg23715586 chr3:58305044 RPP14 0.46 7.78 0.39 9.39e-14 Platelet count; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg00431813 chr7:1051703 C7orf50 -0.48 -8.19 -0.41 5.51e-15 Longevity;Endometriosis; LUSC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg11247378 chr22:39784982 NA 0.66 13.49 0.59 2.09e-33 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg26597838 chr10:835615 NA 0.83 11.57 0.54 2.8e-26 Eosinophil percentage of granulocytes; LUSC cis rs6692209 1 rs6692209 chr1:152506444 C/T cg20991723 chr1:152506922 NA 0.53 9.87 0.48 2.55e-20 Plantar warts; LUSC cis rs713587 0.563 rs1529897 chr2:25086827 T/G cg04586622 chr2:25135609 ADCY3 0.39 8.09 0.4 1.11e-14 Body mass index in non-asthmatics; LUSC cis rs7904985 1.000 rs12777097 chr10:88115638 G/A cg07322936 chr10:88137208 NA -0.58 -7.41 -0.38 1.02e-12 Barrett's esophagus; LUSC cis rs9300255 0.568 rs1727300 chr12:123664205 C/T cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.37 -0.33 6.33e-10 Neutrophil percentage of white cells; LUSC cis rs2404602 0.692 rs7174673 chr15:77071998 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.94e-12 Blood metabolite levels; LUSC trans rs208520 0.690 rs4710564 chr6:66823478 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 14.92 0.63 6.44e-39 Exhaled nitric oxide output; LUSC cis rs7903847 0.642 rs4635018 chr10:99137839 C/G cg08345082 chr10:99160200 RRP12 0.37 7.09 0.36 7.82e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs4076764 0.515 rs4657268 chr1:163376507 A/T cg06092702 chr1:163392909 NA -0.35 -5.94 -0.31 7e-9 Motion sickness; LUSC cis rs2806561 0.894 rs629107 chr1:23537971 C/T cg19743168 chr1:23544995 NA 0.47 10.3 0.49 8.8e-22 Height; LUSC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg13393036 chr8:95962371 TP53INP1 -0.41 -8.51 -0.42 6.15e-16 Type 2 diabetes; LUSC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg09835421 chr16:68378352 PRMT7 -0.54 -6.12 -0.32 2.56e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs7580658 0.724 rs7568261 chr2:128117324 C/T cg09760422 chr2:128146352 NA -0.27 -5.86 -0.31 1.08e-8 Protein C levels; LUSC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11890956 chr21:40555474 PSMG1 1.03 21.0 0.75 5.38e-63 Cognitive function; LUSC cis rs9747201 0.962 rs6502062 chr17:80086177 T/G cg18209359 chr17:80159595 CCDC57 0.38 6.36 0.33 6.61e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6840360 0.554 rs61308159 chr4:152728941 G/A cg22705602 chr4:152727874 NA 0.36 7.69 0.39 1.63e-13 Intelligence (multi-trait analysis); LUSC cis rs240764 0.669 rs846800 chr6:101270498 C/G cg09795085 chr6:101329169 ASCC3 0.43 6.32 0.33 8.46e-10 Neuroticism; LUSC cis rs868036 0.681 rs28376010 chr15:68063739 G/T cg05925327 chr15:68127851 NA -0.43 -6.71 -0.34 8.36e-11 Restless legs syndrome; LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg18404041 chr3:52824283 ITIH1 -0.64 -12.53 -0.57 8.86e-30 Bipolar disorder; LUSC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg08499158 chr17:42289980 UBTF -0.38 -6.12 -0.32 2.69e-9 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14950855 chr12:49740781 DNAJC22 -0.42 -6.2 -0.32 1.69e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17125944 0.686 rs73304351 chr14:53375140 G/A cg00686598 chr14:53173677 PSMC6 0.82 7.14 0.36 6.05e-12 Alzheimer's disease (late onset); LUSC cis rs12101261 0.580 rs8003515 chr14:81446242 G/C cg06600135 chr14:81408086 NA 0.46 7.11 0.36 6.96e-12 Graves' disease; LUSC cis rs7408868 1.000 rs10418305 chr19:15278808 C/G cg14696996 chr19:15285081 NOTCH3 0.97 9.33 0.45 1.56e-18 Pulse pressure; LUSC cis rs62400317 0.859 rs10948220 chr6:45236654 A/G cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg21951975 chr1:209979733 IRF6 -0.58 -7.07 -0.36 9.28e-12 Cleft lip with or without cleft palate; LUSC cis rs9479482 0.686 rs2010259 chr6:150385475 C/T cg25797454 chr6:150327115 RAET1K 0.33 7.19 0.37 4.22e-12 Alopecia areata; LUSC cis rs6740322 0.895 rs6744746 chr2:43555805 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.53 7.62 0.38 2.67e-13 Coronary artery disease; LUSC cis rs600231 0.665 rs2105608 chr11:65228618 T/A cg17120908 chr11:65337727 SSSCA1 -0.54 -9.25 -0.45 2.82e-18 Bone mineral density; LUSC cis rs6700896 0.500 rs66728245 chr1:66127710 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg20608306 chr11:116969690 SIK3 0.36 6.78 0.35 5.58e-11 Blood protein levels; LUSC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg03060546 chr3:49711283 APEH 0.71 12.08 0.55 4.16e-28 Resting heart rate; LUSC cis rs17270561 0.609 rs9358872 chr6:25727517 G/A cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC cis rs3784262 1.000 rs4646593 chr15:58302467 A/G cg12031962 chr15:58353849 ALDH1A2 -0.33 -6.04 -0.31 4.18e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7113850 0.541 rs2896686 chr11:24213156 G/A ch.11.24196551F chr11:24239977 NA 0.92 7.82 0.39 6.77e-14 Bone fracture in osteoporosis; LUSC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg09796270 chr17:17721594 SREBF1 0.33 5.66 0.3 3.25e-8 Total body bone mineral density; LUSC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.65 -0.47 1.32e-19 Bipolar disorder; LUSC cis rs12367572 1.000 rs12822444 chr12:45276677 G/A cg04608330 chr12:45269318 NELL2 -0.58 -9.24 -0.45 2.85e-18 Gut microbiome composition (summer); LUSC cis rs12986413 1.000 rs4807208 chr19:2170205 A/C cg09261902 chr19:2140048 AP3D1 0.31 5.99 0.31 5.38e-9 Height; LUSC trans rs6502050 0.749 rs7209948 chr17:80086804 T/G cg07393940 chr7:158741817 NA -0.37 -6.68 -0.34 1.02e-10 Life satisfaction; LUSC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg04455712 chr21:45112962 RRP1B 0.43 8.14 0.41 8.09e-15 Mean corpuscular volume; LUSC cis rs7539542 0.600 rs9943282 chr1:202895140 C/T cg19681188 chr1:202830198 LOC148709 0.4 5.91 0.31 8.37e-9 Mean platelet volume; LUSC cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg23625390 chr15:77176239 SCAPER 0.51 7.85 0.39 5.7e-14 Blood metabolite levels; LUSC trans rs8073060 0.586 rs17638867 chr17:34052513 C/T cg19694781 chr19:47549865 TMEM160 1.13 18.01 0.7 3.64e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs61931739 0.570 rs7315655 chr12:33912869 G/A cg13010199 chr12:38710504 ALG10B 0.41 6.12 0.32 2.65e-9 Morning vs. evening chronotype; LUSC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg11752832 chr7:134001865 SLC35B4 0.56 8.68 0.43 1.72e-16 Mean platelet volume; LUSC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs17685 0.753 rs2302435 chr7:75676987 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.73 0.39 1.27e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2625529 0.818 rs16956241 chr15:72111688 G/T cg16672083 chr15:72433130 SENP8 -0.52 -7.36 -0.37 1.48e-12 Red blood cell count; LUSC cis rs9814567 1.000 rs6439484 chr3:134249899 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg21344124 chr8:22857393 RHOBTB2 0.39 5.99 0.31 5.38e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg03929089 chr4:120376271 NA -0.98 -16.19 -0.66 6.36e-44 Coronary artery disease; LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.15e-9 Prudent dietary pattern; LUSC cis rs28374715 0.578 rs7165914 chr15:41632451 C/T cg18705301 chr15:41695430 NDUFAF1 -1.07 -22.54 -0.78 4.9e-69 Ulcerative colitis; LUSC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg07741184 chr6:167504864 NA 0.36 6.65 0.34 1.22e-10 Crohn's disease; LUSC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg15445000 chr17:37608096 MED1 -0.38 -6.46 -0.33 3.79e-10 Glomerular filtration rate (creatinine); LUSC cis rs75804782 0.521 rs72993074 chr2:239413582 T/G cg18131467 chr2:239335373 ASB1 -0.68 -6.29 -0.33 9.76e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7586879 0.789 rs13428763 chr2:25132855 T/G cg01884057 chr2:25150051 NA 0.42 8.58 0.43 3.58e-16 Body mass index; LUSC cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg01028140 chr2:1542097 TPO -0.37 -6.08 -0.32 3.19e-9 IgG glycosylation; LUSC cis rs9815354 0.812 rs17217746 chr3:41926021 A/G cg03022575 chr3:42003672 ULK4 0.83 8.88 0.44 4.32e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg26597838 chr10:835615 NA 0.98 13.46 0.59 2.8e-33 Eosinophil percentage of granulocytes; LUSC cis rs13401104 0.796 rs60159414 chr2:237119178 T/C cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs17818399 0.962 rs2122715 chr2:46845849 A/G cg02822958 chr2:46747628 ATP6V1E2 0.42 6.59 0.34 1.69e-10 Height; LUSC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg04455712 chr21:45112962 RRP1B 0.47 8.96 0.44 2.42e-17 Mean corpuscular volume; LUSC cis rs9300255 0.508 rs1716176 chr12:123655467 T/G cg05973401 chr12:123451056 ABCB9 0.52 6.45 0.33 4.04e-10 Neutrophil percentage of white cells; LUSC cis rs28655083 0.529 rs662101 chr16:77105405 G/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.43 -7.02 -0.36 1.25e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.86 0.51 9.54e-24 Monocyte percentage of white cells; LUSC cis rs7267979 0.565 rs3752273 chr20:25594783 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.99 -0.58 1.65e-31 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10035607 chr16:30366449 CD2BP2 0.41 6.86 0.35 3.39e-11 Triglycerides; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25367318 chr6:138725211 HEBP2 0.43 6.23 0.32 1.4e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7267979 1.000 rs2387884 chr20:25379069 C/T cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2742234 0.590 rs1254960 chr10:43699657 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 6.99 0.36 1.53e-11 Hirschsprung disease; LUSC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg07936489 chr17:37558343 FBXL20 -0.71 -10.02 -0.48 7.57e-21 Glomerular filtration rate (creatinine); LUSC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg04455712 chr21:45112962 RRP1B 0.5 9.47 0.46 5.26e-19 Mean corpuscular volume; LUSC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg17143192 chr8:8559678 CLDN23 0.59 8.48 0.42 7.54e-16 Obesity-related traits; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg14004847 chr7:1930337 MAD1L1 -0.54 -8.26 -0.41 3.41e-15 Bipolar disorder and schizophrenia; LUSC cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg09796270 chr17:17721594 SREBF1 0.43 7.6 0.38 2.97e-13 Total body bone mineral density; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02351056 chr10:126480372 METTL10 -0.45 -6.76 -0.35 6.27e-11 Electrocardiographic conduction measures; LUSC cis rs548987 0.529 rs651578 chr6:25873883 T/C cg03517284 chr6:25882590 NA -0.39 -5.84 -0.3 1.21e-8 Homocysteine levels; LUSC cis rs7216064 0.953 rs11871285 chr17:65840809 G/T cg12091567 chr17:66097778 LOC651250 -0.75 -9.35 -0.46 1.27e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6961069 0.806 rs4728183 chr7:80256003 A/G cg04458919 chr7:80252533 CD36 0.37 6.67 0.34 1.08e-10 Platelet count; LUSC trans rs17685 0.712 rs6953342 chr7:75776753 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 18.97 0.72 5.86e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1865760 0.865 rs9393678 chr6:25945819 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.11e-11 Height; LUSC cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg21545522 chr1:205238299 TMCC2 0.52 9.92 0.48 1.63e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg12463550 chr7:65579703 CRCP 0.57 8.52 0.42 5.51e-16 Aortic root size; LUSC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg06850241 chr22:41845214 NA -0.31 -5.7 -0.3 2.7e-8 Vitiligo; LUSC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg03676636 chr4:99064102 C4orf37 0.36 7.82 0.39 6.87e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7833986 1.000 rs13273123 chr8:57100791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 -0.58 -8.67 -0.43 1.87e-16 Height; LUSC cis rs72781680 1.000 rs17762102 chr2:24085606 A/G cg08917208 chr2:24149416 ATAD2B 0.87 10.02 0.48 7.9e-21 Lymphocyte counts; LUSC cis rs7129556 0.520 rs7943742 chr11:77268856 C/T cg12586386 chr11:77299805 AQP11 0.23 5.71 0.3 2.49e-8 Weight loss (gastric bypass surgery); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04215179 chr7:23719682 C7orf46 -0.45 -5.99 -0.31 5.3300000000000004e-09 Bipolar disorder and schizophrenia; LUSC cis rs12579753 1.000 rs7306395 chr12:82175867 A/G cg21231944 chr12:82153410 PPFIA2 -0.41 -6.2 -0.32 1.68e-9 Resting heart rate; LUSC cis rs9325144 0.647 rs12229104 chr12:39110811 T/A cg26384229 chr12:38710491 ALG10B -0.62 -9.67 -0.47 1.16e-19 Morning vs. evening chronotype; LUSC cis rs1577917 0.655 rs9359658 chr6:86305769 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 9.54 0.46 3.12e-19 Response to antipsychotic treatment; LUSC cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7769051 1.000 rs73554431 chr6:133129922 T/G cg07930552 chr6:133119739 C6orf192 0.77 9.86 0.47 2.67e-20 Type 2 diabetes nephropathy; LUSC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg16624210 chr5:671434 TPPP 0.5 6.52 0.34 2.56e-10 Obesity-related traits; LUSC cis rs6541297 0.555 rs910502 chr1:230294185 A/T cg20703242 chr1:230279135 GALNT2 0.51 5.66 0.3 3.34e-8 Coronary artery disease; LUSC cis rs977987 0.806 rs4993970 chr16:75411619 G/A cg04384234 chr16:75411784 CFDP1 -0.44 -7.28 -0.37 2.4e-12 Dupuytren's disease; LUSC cis rs1878931 0.507 rs67218524 chr16:3403057 G/T cg00484396 chr16:3507460 NAT15 0.46 6.58 0.34 1.86e-10 Body mass index (adult); LUSC cis rs4930103 0.935 rs2075744 chr11:2018449 A/G cg23202291 chr11:1979235 NA 0.4 6.14 0.32 2.31e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg06552810 chr11:31128660 NA -0.41 -7.14 -0.36 5.86e-12 Red blood cell count; LUSC cis rs6582630 0.622 rs11182005 chr12:38441292 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.06e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs593982 0.920 rs618456 chr11:65475620 C/T cg08755490 chr11:65554678 OVOL1 1.53 13.68 0.6 3.88e-34 Atopic dermatitis; LUSC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg17252645 chr8:143867129 LY6D 0.38 6.67 0.34 1.06e-10 Urinary tract infection frequency; LUSC cis rs1448094 0.967 rs7301496 chr12:86321212 A/C cg02569458 chr12:86230093 RASSF9 0.42 6.71 0.34 8.27e-11 Major depressive disorder; LUSC cis rs7705502 1.000 rs17694791 chr5:173326891 C/T cg18693985 chr5:173351052 CPEB4 -0.37 -5.85 -0.3 1.19e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg02353165 chr6:42928485 GNMT 0.66 11.26 0.52 3.78e-25 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2816062 0.786 rs742486 chr1:18900829 G/A cg18795169 chr1:18902165 NA -1.0 -23.38 -0.79 2.57e-72 Urate levels in lean individuals; LUSC cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.16 0.49 2.64e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs12210905 0.925 rs17345718 chr6:26964258 A/G cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs11098499 0.779 rs10016060 chr4:120298412 A/G cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs6692729 0.965 rs1289395 chr1:227042462 T/C cg10327440 chr1:227177885 CDC42BPA 0.48 6.77 0.35 5.84e-11 Electrodermal activity; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg02675527 chr2:114030824 PAX8;LOC440839 0.37 5.75 0.3 1.99e-8 Lymphocyte counts; LUSC cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg05165339 chr4:1420672 NA -0.3 -6.74 -0.35 7.03e-11 Longevity; LUSC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg15704280 chr7:45808275 SEPT13 -1.08 -19.9 -0.74 1.14e-58 Coronary artery disease; LUSC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg00599273 chr12:58146742 CDK4 0.31 5.81 0.3 1.48e-8 Multiple sclerosis; LUSC cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 27.97 0.84 1.54e-89 Chronic sinus infection; LUSC cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg05347473 chr6:146136440 FBXO30 0.38 6.37 0.33 6.3e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs10761482 0.861 rs10821728 chr10:62099135 T/A cg18175470 chr10:62150864 ANK3 -0.5 -7.11 -0.36 7.07e-12 Schizophrenia; LUSC cis rs11958404 0.932 rs56204919 chr5:157431084 C/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 9.91e-22 Colonoscopy-negative controls vs population controls; LUSC trans rs9951602 0.920 rs28639710 chr18:76679847 G/A cg02800362 chr5:177631904 HNRNPAB 0.79 8.72 0.43 1.37e-16 Obesity-related traits; LUSC cis rs7954584 0.546 rs10840630 chr12:122352445 C/T cg22618164 chr12:122356400 WDR66 0.62 9.01 0.44 1.63e-17 Mean corpuscular volume; LUSC trans rs9291683 1.000 rs9291683 chr4:10324160 C/T cg26043149 chr18:55253948 FECH 0.48 7.38 0.37 1.3e-12 Bone mineral density; LUSC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg00800038 chr16:89945340 TCF25 -0.75 -6.58 -0.34 1.83e-10 Skin colour saturation; LUSC cis rs9467773 1.000 rs9467797 chr6:26568473 A/T cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg07701084 chr6:150067640 NUP43 0.58 9.09 0.45 9.32e-18 Lung cancer; LUSC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg05347473 chr6:146136440 FBXO30 -0.47 -7.77 -0.39 9.65e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs11758351 0.929 rs6906367 chr6:26187125 C/T cg23601095 chr6:26197514 HIST1H3D 0.51 6.02 0.31 4.55e-9 Gout;Renal underexcretion gout; LUSC cis rs1107366 0.722 rs1992855 chr3:125909669 C/T cg01346077 chr3:125931526 NA -0.33 -6.37 -0.33 6.17e-10 Metabolite levels; LUSC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC trans rs9929218 0.954 rs12596834 chr16:68823199 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.09 -0.52 1.52e-24 Colorectal cancer; LUSC trans rs1973993 0.544 rs2800427 chr1:97002766 A/C cg10631902 chr5:14652156 NA 0.47 7.53 0.38 4.85e-13 Weight; LUSC cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -7.9 -0.4 4.1e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9303280 0.901 rs7216389 chr17:38069949 C/T cg26162295 chr17:38119207 GSDMA -0.24 -5.68 -0.3 2.95e-8 Self-reported allergy; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg18595293 chr21:44527201 U2AF1 0.5 6.1 0.32 2.86e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg24642439 chr20:33292090 TP53INP2 -0.48 -7.11 -0.36 7.2e-12 Glomerular filtration rate (creatinine); LUSC cis rs6426558 0.537 rs4500279 chr1:227484482 G/A cg10327440 chr1:227177885 CDC42BPA 0.55 7.59 0.38 3.1400000000000003e-13 Neutrophil percentage of white cells; LUSC cis rs11148252 0.740 rs3803264 chr13:52971893 A/G cg00495681 chr13:53174319 NA -0.54 -8.67 -0.43 1.89e-16 Lewy body disease; LUSC cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.16 0.36 5.14e-12 Hip circumference adjusted for BMI; LUSC trans rs6582630 0.519 rs7294300 chr12:38277359 C/A cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg18230493 chr5:56204884 C5orf35 -0.58 -9.07 -0.44 1.06e-17 Breast cancer;Breast cancer (early onset); LUSC trans rs10817971 0.503 rs10817967 chr9:119712401 C/T cg20710266 chr15:96877855 NR2F2 0.35 5.99 0.31 5.32e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4595586 0.545 rs2388177 chr12:39364403 T/C cg13010199 chr12:38710504 ALG10B 0.42 6.12 0.32 2.66e-9 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14969806 chr1:5919854 NA 0.44 6.88 0.35 2.93e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7939886 0.920 rs74707325 chr11:56005562 T/A cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg09033563 chr22:24373618 LOC391322 -0.48 -6.47 -0.33 3.45e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9300255 0.722 rs11830103 chr12:123823546 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 5.9 0.31 8.85e-9 Neutrophil percentage of white cells; LUSC cis rs6906287 0.647 rs2356183 chr6:118770264 A/G cg21191810 chr6:118973309 C6orf204 0.33 6.0 0.31 5.17e-9 Electrocardiographic conduction measures; LUSC cis rs2273669 0.667 rs12214567 chr6:109317330 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg13647721 chr17:30228624 UTP6 0.64 6.9 0.35 2.68e-11 Hip circumference adjusted for BMI; LUSC cis rs12144044 0.701 rs2999159 chr1:113230758 A/G cg22162597 chr1:113214053 CAPZA1 -0.67 -7.77 -0.39 9.86e-14 Glomerular filtration rate (creatinine); LUSC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.82 12.01 0.55 7.35e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs17685 0.712 rs6954569 chr7:75738885 T/A cg19862616 chr7:65841803 NCRNA00174 1.11 19.03 0.72 3.14e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg11941060 chr3:133502564 NA -0.43 -6.19 -0.32 1.75e-9 Iron status biomarkers; LUSC cis rs116988415 0.584 rs17767466 chr14:65252095 G/T cg25083366 chr14:65239357 SPTB 0.66 6.82 0.35 4.17e-11 Daytime sleep phenotypes; LUSC cis rs3806843 1.000 rs2240694 chr5:140183058 G/A cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.37e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6121246 0.529 rs6060134 chr20:30176794 A/G cg21427119 chr20:30132790 HM13 -0.43 -6.15 -0.32 2.26e-9 Mean corpuscular hemoglobin; LUSC cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.56 -0.6 1.12e-33 Chronic sinus infection; LUSC cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.61 -0.57 4.37e-30 Chronic sinus infection; LUSC cis rs9354352 0.935 rs9354354 chr6:66699333 A/G cg07460842 chr6:66804631 NA -0.67 -9.75 -0.47 6.1e-20 Initial pursuit acceleration in psychotic disorders; LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg01802117 chr1:53393560 SCP2 -0.37 -6.02 -0.31 4.52e-9 Monocyte count; LUSC cis rs4460629 0.521 rs7367897 chr1:155083289 A/T cg23973274 chr1:155060172 NA -0.31 -6.24 -0.32 1.36e-9 Serum magnesium levels; LUSC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg08975724 chr8:8085496 FLJ10661 0.41 6.11 0.32 2.8e-9 Joint mobility (Beighton score); LUSC cis rs734999 0.588 rs6689711 chr1:2531467 T/C cg18932078 chr1:2524107 MMEL1 -0.33 -7.21 -0.37 3.83e-12 Ulcerative colitis; LUSC trans rs561341 0.739 rs1978116 chr17:30220978 A/C cg20587970 chr11:113659929 NA -0.75 -9.69 -0.47 9.73e-20 Hip circumference adjusted for BMI; LUSC cis rs10089 0.953 rs10463839 chr5:127519675 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.83 10.3 0.49 8.56e-22 Ileal carcinoids; LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg14004847 chr7:1930337 MAD1L1 -0.47 -6.95 -0.36 1.93e-11 Bipolar disorder and schizophrenia; LUSC trans rs225245 0.755 rs8078905 chr17:34009029 T/C cg19694781 chr19:47549865 TMEM160 -0.4 -6.41 -0.33 5e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs8072100 0.934 rs6504872 chr17:45438952 C/T cg03886242 chr7:26192032 NFE2L3 -0.36 -5.98 -0.31 5.69e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 8.0 0.4 2.01e-14 Bipolar disorder; LUSC cis rs2742234 0.541 rs1254959 chr10:43700979 C/G cg15436174 chr10:43711423 RASGEF1A 0.43 6.99 0.36 1.53e-11 Hirschsprung disease; LUSC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.23e-10 Developmental language disorder (linguistic errors); LUSC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg12463550 chr7:65579703 CRCP 0.43 6.39 0.33 5.64e-10 Aortic root size; LUSC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg19230755 chr7:65878503 NA 0.41 5.8 0.3 1.58e-8 Aortic root size; LUSC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg10117171 chr1:25599238 RHD -0.41 -6.27 -0.32 1.14e-9 Erythrocyte sedimentation rate; LUSC cis rs9810089 1.000 rs1279831 chr3:135933264 A/G cg12473912 chr3:136751656 NA 0.33 5.65 0.3 3.45e-8 Gestational age at birth (child effect); LUSC cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg15839431 chr19:19639596 YJEFN3 0.6 6.75 0.35 6.71e-11 Bipolar disorder; LUSC cis rs8062405 0.755 rs4149398 chr16:28608938 C/G cg16576597 chr16:28551801 NUPR1 0.32 6.53 0.34 2.49e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7106204 0.609 rs12788438 chr11:24284068 G/T ch.11.24196551F chr11:24239977 NA 0.72 6.04 0.31 4.08e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg24110177 chr3:50126178 RBM5 0.66 11.39 0.53 1.28e-25 Body mass index; LUSC cis rs752010 0.714 rs7552928 chr1:42086664 C/T cg06885757 chr1:42089581 HIVEP3 0.48 10.12 0.48 3.59e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg06634786 chr22:41940651 POLR3H 0.47 5.69 0.3 2.71e-8 Vitiligo; LUSC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.51e-10 Total body bone mineral density; LUSC trans rs62344088 1.000 rs10037843 chr5:120078 G/C cg11454300 chr2:2256402 MYT1L 0.75 6.03 0.31 4.27e-9 Asthma (childhood onset); LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg24675658 chr1:53192096 ZYG11B -0.57 -8.78 -0.43 8.66e-17 Monocyte count; LUSC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg06238570 chr21:40685208 BRWD1 0.5 7.62 0.38 2.65e-13 Cognitive function; LUSC cis rs4704187 0.687 rs4703657 chr5:74461850 T/G cg03227963 chr5:74354835 NA 0.32 6.93 0.35 2.21e-11 Response to amphetamines; LUSC trans rs79976124 0.797 rs77895756 chr6:66626782 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 8.49 0.42 7.03e-16 Type 2 diabetes; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg14893161 chr1:205819251 PM20D1 1.01 22.07 0.77 3.27e-67 Menarche (age at onset); LUSC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg03233332 chr7:66118400 NA 0.42 6.09 0.32 3.02e-9 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13826709 chr21:46708041 POFUT2;LOC642852 -0.45 -6.74 -0.35 6.82e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2018683 0.700 rs13227954 chr7:29017188 A/C cg19402173 chr7:128379420 CALU 0.48 7.68 0.39 1.78e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs17270561 0.609 rs9356984 chr6:25725481 C/T cg17691542 chr6:26056736 HIST1H1C -0.55 -7.72 -0.39 1.4e-13 Iron status biomarkers; LUSC cis rs3740713 1.000 rs73440636 chr11:18473556 C/T cg07915343 chr11:18477680 LDHAL6A -0.56 -7.08 -0.36 8.47e-12 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1577917 1.000 rs13196930 chr6:86652245 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs8060686 0.641 rs12447640 chr16:68150527 A/G cg05110241 chr16:68378359 PRMT7 -0.58 -6.62 -0.34 1.41e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg01097406 chr16:89675127 NA -0.32 -5.96 -0.31 6.24e-9 Vitiligo; LUSC cis rs7647973 0.626 rs62260723 chr3:49872124 T/C cg13072238 chr3:49761600 GMPPB 0.68 8.82 0.43 6.64e-17 Menarche (age at onset); LUSC cis rs7607369 0.536 rs12623740 chr2:219665715 T/A cg02176678 chr2:219576539 TTLL4 -0.51 -8.91 -0.44 3.38e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs4589502 0.925 rs57729347 chr15:67136438 G/A cg09911534 chr15:67153556 NA -0.5 -6.37 -0.33 6.3e-10 Lung cancer (smoking interaction); LUSC cis rs523522 0.962 rs509445 chr12:121017243 A/C cg12219531 chr12:120966889 COQ5 0.64 8.85 0.44 5.22e-17 High light scatter reticulocyte count; LUSC cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg07061783 chr6:25882402 NA -0.37 -5.78 -0.3 1.69e-8 Blood metabolite levels; LUSC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg11247378 chr22:39784982 NA -0.52 -7.61 -0.38 2.78e-13 IgG glycosylation; LUSC cis rs7666738 0.571 rs7683769 chr4:99091742 T/C cg17366294 chr4:99064904 C4orf37 0.51 8.78 0.43 8.8e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11644478 chr21:40555479 PSMG1 -0.59 -9.3 -0.45 1.91e-18 Menarche (age at onset); LUSC cis rs72781680 0.948 rs72796319 chr2:24133027 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.34 0.67 1.6e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12681287 0.640 rs13269259 chr8:87470453 G/A cg27223183 chr8:87520930 FAM82B -0.54 -7.45 -0.38 7.92e-13 Caudate activity during reward; LUSC cis rs3099143 1.000 rs2011635 chr15:77134891 T/A cg21673338 chr15:77095150 SCAPER -0.78 -7.26 -0.37 2.77e-12 Recalcitrant atopic dermatitis; LUSC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg07636037 chr3:49044803 WDR6 1.05 18.84 0.72 1.88e-54 Parkinson's disease; LUSC cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg24558204 chr6:135376177 HBS1L 0.57 8.56 0.42 4.24e-16 Red blood cell count; LUSC trans rs17112190 1.000 rs112476011 chr10:98558276 C/A cg05472874 chr22:44258179 SULT4A1 0.71 6.29 0.33 9.79e-10 Multiple myeloma (IgH translocation); LUSC cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.1 -0.32 2.98e-9 Intelligence (multi-trait analysis); LUSC cis rs7809950 1.000 rs2712200 chr7:107142435 G/T cg23024343 chr7:107201750 COG5 -0.55 -8.73 -0.43 1.27e-16 Coronary artery disease; LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.13 0.36 6.07e-12 Bipolar disorder; LUSC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg05802129 chr4:122689817 NA -0.52 -8.67 -0.43 1.96e-16 Type 2 diabetes; LUSC cis rs9807841 0.568 rs3859514 chr19:10748820 T/C cg09936142 chr19:10668400 KRI1 -0.4 -6.34 -0.33 7.33e-10 Inflammatory skin disease; LUSC cis rs4319547 0.656 rs7294559 chr12:122837564 C/A cg23029597 chr12:123009494 RSRC2 -0.74 -9.33 -0.45 1.52e-18 Body mass index; LUSC cis rs977987 0.835 rs8046109 chr16:75360096 A/G cg04384234 chr16:75411784 CFDP1 -0.39 -6.42 -0.33 4.57e-10 Dupuytren's disease; LUSC cis rs9811920 0.809 rs793443 chr3:99573547 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -5.92 -0.31 7.83e-9 Axial length; LUSC cis rs8062405 0.755 rs7186573 chr16:28587389 T/C cg07382826 chr16:28625726 SULT1A1 0.27 5.8 0.3 1.56e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs17014483 0.749 rs3017900 chr4:89639466 T/C cg01026744 chr4:89619053 NAP1L5;HERC3 0.69 6.08 0.32 3.28e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4474465 0.646 rs6592794 chr11:78275743 A/G cg27205649 chr11:78285834 NARS2 0.53 6.56 0.34 2.1e-10 Alzheimer's disease (survival time); LUSC cis rs2579500 0.660 rs6711452 chr2:97139307 G/A cg23100626 chr2:96804247 ASTL 0.25 5.72 0.3 2.35e-8 Eosinophil counts;Eosinophil percentage of white cells; LUSC trans rs9467711 0.790 rs35162296 chr6:26318262 C/T cg01620082 chr3:125678407 NA -0.6 -6.11 -0.32 2.74e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs1814175 0.935 rs7925863 chr11:49615802 C/A cg15704280 chr7:45808275 SEPT13 -1.09 -21.42 -0.76 1.17e-64 Height; LUSC cis rs17401966 0.838 rs1013953 chr1:10319459 T/A cg19773385 chr1:10388646 KIF1B -0.51 -8.81 -0.43 6.93e-17 Hepatocellular carcinoma; LUSC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.32 -6.21 -0.32 1.54e-9 Colonoscopy-negative controls vs population controls; LUSC trans rs9929218 0.679 rs9924886 chr16:68743939 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.96 -0.55 1.07e-27 Colorectal cancer; LUSC cis rs9297145 0.678 rs62473051 chr7:98781955 C/T cg05967295 chr7:98741636 SMURF1 0.92 12.77 0.57 1.11e-30 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs10838798 0.504 rs7121133 chr11:48156131 G/A cg18512352 chr11:47633146 NA -0.28 -5.73 -0.3 2.28e-8 Height; LUSC trans rs7937682 0.883 rs568038 chr11:111432161 A/C cg18187862 chr3:45730750 SACM1L -0.59 -7.4 -0.38 1.09e-12 Primary sclerosing cholangitis; LUSC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg21724239 chr8:58056113 NA 0.59 6.17 0.32 1.97e-9 Developmental language disorder (linguistic errors); LUSC cis rs11864453 0.826 rs12448315 chr16:72147242 G/T cg01557791 chr16:72042693 DHODH -0.51 -7.43 -0.38 8.96e-13 Fibrinogen levels; LUSC cis rs17155006 0.664 rs405869 chr7:107742609 T/C cg05962710 chr7:107745446 LAMB4 -0.35 -6.17 -0.32 1.97e-9 Pneumococcal bacteremia; LUSC cis rs10875746 0.951 rs7485355 chr12:48548342 G/A cg13454099 chr12:49076203 C12orf41 -0.52 -6.03 -0.31 4.46e-9 Longevity (90 years and older); LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.88 0.66 1.09e-42 Platelet count; LUSC cis rs1729951 0.575 rs1654926 chr3:136709924 G/A cg21827317 chr3:136751795 NA 0.38 6.95 0.36 1.88e-11 Neuroticism; LUSC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg06221963 chr1:154839813 KCNN3 -0.62 -13.89 -0.61 6.1e-35 Prostate cancer; LUSC cis rs6964587 1.000 rs1859114 chr7:91682848 T/C cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg10150615 chr22:24372951 LOC391322 -0.43 -7.14 -0.36 5.99e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg09267113 chr7:98030324 BAIAP2L1 0.4 6.1 0.32 2.92e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1348850 0.526 rs2178017 chr2:178374788 G/T cg22681709 chr2:178499509 PDE11A -0.45 -6.65 -0.34 1.19e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs2335704 1.000 rs2335704 chr2:205864832 G/T cg17022038 chr19:18260479 MAST3 -0.52 -5.98 -0.31 5.87e-9 Tuberculosis; LUSC cis rs9653442 0.628 rs12474386 chr2:100857017 G/A cg07810366 chr2:100720526 AFF3 -0.36 -5.93 -0.31 7.56e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs11758351 1.000 rs76329209 chr6:26196430 A/G cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.12 0.36 6.6e-12 Platelet count; LUSC cis rs6565180 0.632 rs8050812 chr16:30385837 C/T cg17640201 chr16:30407289 ZNF48 -0.82 -12.64 -0.57 3.28e-30 Tonsillectomy; LUSC cis rs611744 0.647 rs702808 chr8:109252554 T/C cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 7.89e-10 Dupuytren's disease; LUSC cis rs12681287 0.752 rs4641037 chr8:87268379 A/G cg27223183 chr8:87520930 FAM82B -0.43 -5.66 -0.3 3.34e-8 Caudate activity during reward; LUSC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg06363034 chr20:62225388 GMEB2 -0.46 -7.62 -0.38 2.6e-13 Glioblastoma; LUSC trans rs3749237 1.000 rs11130216 chr3:49736172 C/A cg21659725 chr3:3221576 CRBN 0.64 9.2 0.45 3.96e-18 Resting heart rate; LUSC cis rs66569888 0.507 rs11673736 chr2:106886935 T/C cg15412446 chr2:106886593 NA -0.48 -6.95 -0.36 1.94e-11 Facial morphology (factor 23); LUSC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg14552801 chr7:65878734 NA -0.46 -6.54 -0.34 2.31e-10 Aortic root size; LUSC cis rs4820539 0.902 rs737846 chr22:23460669 A/G cg14186256 chr22:23484241 RTDR1 0.97 18.01 0.7 3.81e-51 Bone mineral density; LUSC trans rs7819412 0.505 rs17726209 chr8:11022185 C/T cg15556689 chr8:8085844 FLJ10661 0.5 7.01 0.36 1.32e-11 Triglycerides; LUSC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.05 0.55 5.3e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10050311 0.586 rs2054592 chr4:87673445 G/A cg10685359 chr4:87814065 C4orf36 -0.43 -5.66 -0.3 3.19e-8 Insulin-related traits; LUSC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg00810483 chr4:3375144 RGS12 0.3 5.7 0.3 2.7e-8 Serum sulfate level; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg04775059 chr7:64541387 NA -0.54 -8.08 -0.4 1.18e-14 Calcium levels; LUSC cis rs72781680 0.559 rs72796103 chr2:23900382 G/A cg08917208 chr2:24149416 ATAD2B 0.97 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.19 0.45 4.16e-18 Prudent dietary pattern; LUSC cis rs754466 0.874 rs10430531 chr10:79660125 T/C cg17075019 chr10:79541650 NA -0.64 -8.3 -0.41 2.54e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg14552801 chr7:65878734 NA -0.45 -6.48 -0.33 3.36e-10 Aortic root size; LUSC cis rs7582180 0.700 rs4851303 chr2:100962064 T/C cg12002119 chr2:101014098 CHST10 0.35 5.85 0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC cis rs9747201 0.894 rs4503854 chr17:80178696 A/T cg18209359 chr17:80159595 CCDC57 -0.36 -5.82 -0.3 1.39e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3768617 0.565 rs2027080 chr1:183074415 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.87 0.51 9.12e-24 Fuchs's corneal dystrophy; LUSC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.81e-12 Parkinson's disease; LUSC cis rs9326248 0.581 rs11216242 chr11:116901549 G/A cg26566898 chr11:117069891 TAGLN 0.34 6.46 0.33 3.77e-10 Blood protein levels; LUSC cis rs5758659 0.652 rs1063392 chr22:42454950 C/T cg04733989 chr22:42467013 NAGA -0.41 -6.97 -0.36 1.67e-11 Cognitive function; LUSC cis rs1448094 0.617 rs1393612 chr12:86474576 T/C cg00310523 chr12:86230176 RASSF9 -0.33 -5.97 -0.31 5.98e-9 Major depressive disorder; LUSC cis rs11608355 0.538 rs12228876 chr12:109796799 C/A cg19025524 chr12:109796872 NA -0.41 -7.6 -0.38 2.99e-13 Neuroticism; LUSC cis rs11229555 0.645 rs7945992 chr11:58187755 T/A cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg05425664 chr17:57184151 TRIM37 0.59 9.14 0.45 6.22e-18 Intelligence (multi-trait analysis); LUSC trans rs62103177 0.564 rs1715230 chr18:77848002 C/T cg05926928 chr17:57297772 GDPD1 0.9 10.48 0.5 2.15e-22 Opioid sensitivity; LUSC cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.47e-8 Breast cancer; LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.65 11.65 0.54 1.5e-26 Menopause (age at onset); LUSC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg08680598 chr22:49984980 NA -0.34 -6.4 -0.33 5.37e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7481584 0.624 rs397919 chr11:3063094 A/C cg08508325 chr11:3079039 CARS 0.39 8.77 0.43 8.95e-17 Calcium levels; LUSC cis rs4363385 0.679 rs6686285 chr1:152984561 T/G cg00922841 chr1:152955080 SPRR1A -0.42 -7.22 -0.37 3.51e-12 Inflammatory skin disease; LUSC cis rs1751492 0.518 rs11208685 chr1:66070031 A/T cg14976592 chr1:65886160 LEPROT;LEPR 0.56 6.51 0.34 2.68e-10 Soluble leptin receptor levels; LUSC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg14983838 chr19:29218262 NA 0.65 9.18 0.45 4.46e-18 Methadone dose in opioid dependence; LUSC cis rs6938 0.563 rs12917376 chr15:75116167 C/T cg17294928 chr15:75287854 SCAMP5 0.44 6.45 0.33 3.83e-10 Breast cancer; LUSC cis rs6964587 1.000 rs6951972 chr7:91689446 T/G cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -8.22 -0.41 4.45e-15 Lymphocyte counts; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.88 0.54 2.22e-27 Prudent dietary pattern; LUSC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs17270561 0.609 rs1937127 chr6:25769872 G/T cg16482183 chr6:26056742 HIST1H1C -0.55 -7.51 -0.38 5.3e-13 Iron status biomarkers; LUSC cis rs2762353 0.562 rs1165206 chr6:25867566 G/A cg03517284 chr6:25882590 NA -0.38 -6.5 -0.34 2.9e-10 Blood metabolite levels; LUSC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg13647721 chr17:30228624 UTP6 0.59 5.89 0.31 9.59e-9 Hip circumference adjusted for BMI; LUSC cis rs60154123 0.881 rs1774107 chr1:210453923 C/T cg22029157 chr1:209979665 IRF6 0.49 5.79 0.3 1.6e-8 Coronary artery disease; LUSC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg03433033 chr1:76189801 ACADM 0.79 13.27 0.59 1.47e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg19346786 chr7:2764209 NA -0.43 -7.31 -0.37 2.05e-12 Height; LUSC cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg07148914 chr20:33460835 GGT7 0.55 8.35 0.42 1.79e-15 Height; LUSC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg05754148 chr16:3507555 NAT15 0.56 8.57 0.42 3.88e-16 Tuberculosis; LUSC cis rs926392 1.000 rs926391 chr20:37690485 A/G cg27552599 chr20:37590471 DHX35 0.35 6.21 0.32 1.54e-9 Dialysis-related mortality; LUSC cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg21545522 chr1:205238299 TMCC2 0.52 9.99 0.48 9.6e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs61990749 0.597 rs1048147 chr14:78139988 C/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.6 -6.43 -0.33 4.5e-10 Fibroblast growth factor basic levels; LUSC cis rs9914988 0.673 rs12325788 chr17:27080049 G/A cg19789473 chr17:27170043 C17orf63 -0.29 -5.65 -0.3 3.41e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.48 7.27 0.37 2.5e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9303401 0.659 rs8074016 chr17:56840587 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.82 13.29 0.59 1.2e-32 Cognitive test performance; LUSC trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg20587970 chr11:113659929 NA -1.17 -16.31 -0.67 2.14e-44 Hip circumference adjusted for BMI; LUSC cis rs2806974 0.665 rs7984963 chr13:53812390 C/T cg14823544 chr13:53775958 NA -0.36 -6.08 -0.32 3.35e-9 Trans fatty acid levels; LUSC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.54 0.46 3.12e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs3857536 0.741 rs2097679 chr6:66937994 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs3008870 1.000 rs2815370 chr1:67503727 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.01 -15.74 -0.65 3.8e-42 Lymphocyte percentage of white cells; LUSC cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.48 -0.42 7.16e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg16339924 chr4:17578868 LAP3 -0.56 -8.28 -0.41 2.95e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9902453 0.933 rs9908901 chr17:28469713 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.87 0.4 4.86e-14 Coffee consumption (cups per day); LUSC cis rs2455601 0.638 rs2742484 chr11:8988083 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -6.35 -0.33 7.11e-10 Schizophrenia; LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg08859206 chr1:53392774 SCP2 0.5 8.58 0.43 3.56e-16 Monocyte count; LUSC cis rs56399783 0.901 rs73051444 chr7:2866529 G/A cg14895029 chr7:2775587 GNA12 0.46 5.82 0.3 1.38e-8 Childhood ear infection; LUSC trans rs10802346 0.545 rs6662672 chr1:246387611 A/C cg13514129 chr1:39547527 MACF1 0.73 12.07 0.55 4.23e-28 Fractional exhaled nitric oxide (childhood); LUSC cis rs35883536 0.631 rs2783704 chr1:101040652 T/A cg09408571 chr1:101003634 GPR88 0.29 5.84 0.3 1.25e-8 Monocyte count; LUSC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg24549020 chr5:56110836 MAP3K1 0.49 5.92 0.31 7.79e-9 Initial pursuit acceleration; LUSC cis rs427394 0.664 rs274701 chr5:6728707 C/A cg25011763 chr5:6727354 POLS -0.36 -6.18 -0.32 1.83e-9 Menopause (age at onset); LUSC cis rs9300255 0.679 rs4759409 chr12:123719585 G/C cg00376283 chr12:123451042 ABCB9 0.65 8.31 0.41 2.45e-15 Neutrophil percentage of white cells; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg07507251 chr3:52567010 NT5DC2 -0.34 -6.88 -0.35 2.99e-11 Bipolar disorder; LUSC cis rs559928 0.606 rs56311067 chr11:63931607 C/T cg05555928 chr11:63887634 MACROD1 -0.49 -6.05 -0.31 3.95e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4595586 0.545 rs1607041 chr12:39368206 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.42 0.38 1.01e-12 Morning vs. evening chronotype; LUSC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg26119090 chr2:26468346 HADHA;HADHB 0.77 9.25 0.45 2.66e-18 Gut microbiome composition (summer); LUSC trans rs1486139 0.967 rs1903672 chr7:46282452 C/T cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs12458462 0.892 rs2007483 chr18:77476131 A/T cg11879182 chr18:77439856 CTDP1 0.7 11.35 0.53 1.75e-25 Monocyte count; LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg12016809 chr21:47604291 C21orf56 0.46 6.95 0.36 1.87e-11 Testicular germ cell tumor; LUSC cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg01483505 chr11:975446 AP2A2 0.41 5.9 0.31 9.14e-9 Alzheimer's disease (late onset); LUSC trans rs9929218 0.731 rs72785179 chr16:68767912 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -12.63 -0.57 3.82e-30 Colorectal cancer; LUSC cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.43 0.46 7.29e-19 Arsenic metabolism; LUSC cis rs11039100 0.573 rs11038950 chr11:5780334 C/T cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg03929089 chr4:120376271 NA -0.98 -16.38 -0.67 1.14e-44 Coronary artery disease; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg23262073 chr20:60523788 NA 0.48 6.79 0.35 5.27e-11 Body mass index; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg14196790 chr5:131705035 SLC22A5 0.41 7.0 0.36 1.45e-11 Blood metabolite levels; LUSC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg04369109 chr6:150039330 LATS1 -0.52 -7.54 -0.38 4.62e-13 Lung cancer; LUSC cis rs1559088 0.847 rs8100392 chr19:33605933 T/C cg03563238 chr19:33554763 RHPN2 -0.4 -6.26 -0.32 1.16e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9393692 0.537 rs2393594 chr6:26316289 G/A cg13736514 chr6:26305472 NA -0.44 -6.34 -0.33 7.63e-10 Educational attainment; LUSC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC cis rs1728785 0.818 rs12926059 chr16:68569459 T/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC trans rs656319 0.638 rs670044 chr8:9892529 G/T cg15556689 chr8:8085844 FLJ10661 0.46 6.92 0.35 2.35e-11 Myopia (pathological); LUSC cis rs11250097 0.535 rs11250086 chr8:10769783 A/G cg21775007 chr8:11205619 TDH -0.5 -6.79 -0.35 5.17e-11 Neuroticism; LUSC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg26513180 chr16:89883248 FANCA 0.72 11.21 0.52 5.76e-25 Vitiligo; LUSC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11890956 chr21:40555474 PSMG1 0.74 12.18 0.55 1.74e-28 Cognitive function; LUSC cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg16850897 chr7:100343110 ZAN 0.37 5.89 0.31 9.66e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs7923609 0.967 rs7920058 chr10:65293924 T/G cg01631684 chr10:65280961 REEP3 -0.42 -6.46 -0.33 3.74e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs34779708 0.931 rs7079205 chr10:35324619 C/T cg03585969 chr10:35415529 CREM 0.65 9.28 0.45 2.24e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1799949 0.794 rs116409325 chr17:41445460 C/A cg01879757 chr17:41196368 BRCA1 -0.47 -7.31 -0.37 2.04e-12 Menopause (age at onset); LUSC cis rs78456975 1.000 rs10177095 chr2:1570976 C/A cg12573674 chr2:1569213 NA -0.55 -6.13 -0.32 2.44e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg12639453 chr1:2035780 PRKCZ -0.3 -6.54 -0.34 2.36e-10 Height; LUSC trans rs3806843 1.000 rs12055222 chr5:140165568 T/C cg25815440 chr2:42134162 NA -0.25 -5.96 -0.31 6.49e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.802 rs7487591 chr12:86434112 T/C cg02569458 chr12:86230093 RASSF9 0.38 6.07 0.32 3.39e-9 Major depressive disorder; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg12129209 chr14:102276033 PPP2R5C 0.36 6.13 0.32 2.53e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg08645402 chr16:4508243 NA 0.47 7.22 0.37 3.59e-12 Schizophrenia; LUSC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6429082 0.755 rs291372 chr1:235694106 G/C cg26050004 chr1:235667680 B3GALNT2 0.59 8.44 0.42 9.99e-16 Adiposity; LUSC cis rs75804782 0.641 rs72987304 chr2:239345532 C/T cg18131467 chr2:239335373 ASB1 -0.77 -6.63 -0.34 1.3100000000000001e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg22535103 chr8:58192502 C8orf71 -0.58 -7.01 -0.36 1.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg18765753 chr7:1198926 ZFAND2A -0.41 -7.06 -0.36 9.57e-12 Longevity;Endometriosis; LUSC cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg13010199 chr12:38710504 ALG10B 0.65 10.17 0.49 2.37e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg13395646 chr4:1353034 KIAA1530 0.49 6.91 0.35 2.47e-11 Obesity-related traits; LUSC cis rs7927771 0.524 rs7939420 chr11:47723938 A/G cg20307385 chr11:47447363 PSMC3 -0.42 -6.22 -0.32 1.53e-9 Subjective well-being; LUSC cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg03146154 chr1:46216737 IPP -0.57 -8.23 -0.41 4.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2730245 0.527 rs842702 chr7:158696814 C/T cg11984989 chr7:158649758 WDR60 1.13 13.48 0.59 2.25e-33 Height; LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.06 -0.58 8.6e-32 Alzheimer's disease; LUSC cis rs6696846 0.765 rs11240360 chr1:205083865 T/C cg00857998 chr1:205179979 DSTYK 0.65 10.17 0.49 2.45e-21 Red blood cell count; LUSC cis rs12579753 0.879 rs7958657 chr12:82135067 G/A cg07988820 chr12:82153109 PPFIA2 -0.45 -6.42 -0.33 4.69e-10 Resting heart rate; LUSC cis rs912057 0.601 rs1294411 chr6:6739034 T/C cg06612196 chr6:6737390 NA 0.64 13.55 0.6 1.19e-33 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs7168353 0.948 rs10520720 chr15:93634724 A/G cg02918577 chr15:93633145 RGMA -0.48 -7.63 -0.39 2.54e-13 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg00310523 chr12:86230176 RASSF9 0.44 7.86 0.4 5.31e-14 Major depressive disorder; LUSC cis rs2050392 0.799 rs303429 chr10:30708441 C/T cg18806716 chr10:30721971 MAP3K8 -0.48 -7.92 -0.4 3.49e-14 Inflammatory bowel disease; LUSC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg19318889 chr4:1322082 MAEA 0.45 7.41 0.38 1.05e-12 Obesity-related traits; LUSC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg23711669 chr6:146136114 FBXO30 0.9 17.34 0.69 1.79e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg27398817 chr8:82754497 SNX16 -0.51 -6.79 -0.35 5.01e-11 Diastolic blood pressure; LUSC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg23711669 chr6:146136114 FBXO30 -0.68 -11.46 -0.53 7.01e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg11645453 chr3:52864694 ITIH4 0.29 6.6 0.34 1.62e-10 Electroencephalogram traits; LUSC cis rs722599 0.683 rs2302834 chr14:75279395 T/A cg06637938 chr14:75390232 RPS6KL1 0.39 5.68 0.3 2.93e-8 IgG glycosylation; LUSC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg26162295 chr17:38119207 GSDMA 0.24 5.76 0.3 1.91e-8 Self-reported allergy; LUSC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg26335602 chr6:28129616 ZNF389 0.42 5.71 0.3 2.52e-8 Depression; LUSC cis rs9296092 0.560 rs9469505 chr6:33527348 A/G cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs765787 0.530 rs12440238 chr15:45512905 T/C cg24006582 chr15:45444508 DUOX1 0.67 9.67 0.47 1.16e-19 Uric acid levels; LUSC trans rs1998174 0.509 rs12405583 chr1:171812292 A/G cg13482142 chr2:234261155 NA 0.42 6.02 0.31 4.51e-9 Platelet distribution width; LUSC cis rs7903847 0.620 rs9787454 chr10:99155561 A/T cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.83 0.35 4.13e-11 Hip circumference adjusted for BMI; LUSC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs6580649 0.882 rs2286022 chr12:48436647 G/A cg24011408 chr12:48396354 COL2A1 -0.51 -6.75 -0.35 6.42e-11 Lung cancer; LUSC cis rs9929218 0.551 rs8051095 chr16:68722049 G/A cg01251360 chr16:68772225 CDH1 -0.27 -6.38 -0.33 5.89e-10 Colorectal cancer; LUSC cis rs9309473 0.898 rs10201159 chr2:73858965 T/C cg20560298 chr2:73613845 ALMS1 -0.42 -5.94 -0.31 7e-9 Metabolite levels; LUSC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg06656553 chr16:89960601 TCF25 -0.65 -5.7 -0.3 2.65e-8 Skin colour saturation; LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg14820908 chr5:178986412 RUFY1 0.55 9.78 0.47 4.94e-20 Lung cancer; LUSC cis rs7296418 0.922 rs1790134 chr12:123697898 T/C cg00376283 chr12:123451042 ABCB9 0.76 11.54 0.53 3.65e-26 Platelet count; LUSC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg26958806 chr6:27640298 NA 0.62 5.65 0.3 3.47e-8 Depression; LUSC cis rs1185460 1.000 rs1784305 chr11:118942048 G/A cg01677386 chr11:118938358 VPS11 -0.44 -6.08 -0.32 3.33e-9 Coronary artery disease; LUSC cis rs10089 0.953 rs10223203 chr5:127527646 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.87 -11.93 -0.55 1.43e-27 Ileal carcinoids; LUSC cis rs6665290 0.904 rs3795449 chr1:227181838 T/G cg10327440 chr1:227177885 CDC42BPA -1.21 -39.79 -0.91 8.51e-129 Myeloid white cell count; LUSC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg00409905 chr10:38381863 ZNF37A -0.39 -6.73 -0.35 7.48e-11 Extrinsic epigenetic age acceleration; LUSC cis rs983392 0.642 rs636147 chr11:59957092 C/T cg24026212 chr11:59952134 MS4A6A 0.34 6.15 0.32 2.22e-9 Alzheimer's disease (late onset); LUSC cis rs950027 0.620 rs872192 chr15:45614502 A/G cg14582100 chr15:45693742 SPATA5L1 0.48 8.91 0.44 3.37e-17 Response to fenofibrate (adiponectin levels); LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg02423579 chr7:2872169 GNA12 -0.46 -6.5 -0.33 2.96e-10 Height; LUSC trans rs11165623 0.564 rs12752866 chr1:97000181 T/C cg10631902 chr5:14652156 NA -0.41 -6.06 -0.31 3.69e-9 Hip circumference;Waist circumference; LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg02475777 chr4:1388615 CRIPAK -0.41 -6.08 -0.32 3.37e-9 Obesity-related traits; LUSC cis rs4308124 0.708 rs7585313 chr2:111975203 A/G cg04571233 chr2:111982156 NA -0.53 -6.9 -0.35 2.6e-11 Vitiligo; LUSC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg15557168 chr22:42548783 NA -0.46 -7.15 -0.36 5.58e-12 Schizophrenia; LUSC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg15445000 chr17:37608096 MED1 -0.41 -6.95 -0.36 1.95e-11 Glomerular filtration rate (creatinine); LUSC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg22618164 chr12:122356400 WDR66 0.61 9.2 0.45 4.07e-18 Mean corpuscular volume; LUSC cis rs1865721 1.000 rs17283454 chr18:73186619 G/A cg26385618 chr18:73139727 C18orf62 -0.48 -8.02 -0.4 1.86e-14 Intelligence; LUSC cis rs1005224 0.853 rs2360035 chr14:76297093 A/T cg04684003 chr14:76127793 TTLL5;C14orf1 0.63 8.8 0.43 7.64e-17 Large artery stroke; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06224551 chr11:124670268 C11orf61 -0.53 -6.4 -0.33 5.2400000000000005e-10 Bipolar disorder and schizophrenia; LUSC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg10755058 chr3:40428713 ENTPD3 0.35 5.85 0.3 1.17e-8 Renal cell carcinoma; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg23034840 chr1:205782522 SLC41A1 0.78 13.13 0.58 4.86e-32 Monocyte percentage of white cells; LUSC cis rs2760061 0.599 rs849903 chr1:228137659 T/C cg18477163 chr1:228402036 OBSCN -0.55 -9.75 -0.47 6.18e-20 Diastolic blood pressure; LUSC cis rs7805747 0.961 rs55779150 chr7:151406449 A/T cg17611936 chr7:151411526 PRKAG2 0.43 5.9 0.31 9.13e-9 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); LUSC cis rs7172677 0.501 rs56266638 chr15:75393205 T/A cg14664628 chr15:75095509 CSK 0.43 6.07 0.32 3.43e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs243505 0.559 rs7802887 chr7:148494758 C/T cg09806900 chr7:148480153 CUL1 0.64 9.5 0.46 4.32e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7829975 0.591 rs12677543 chr8:8644274 G/C cg14343924 chr8:8086146 FLJ10661 0.43 6.04 0.31 4.07e-9 Mood instability; LUSC cis rs7666738 0.546 rs28444809 chr4:98916934 C/T cg05340658 chr4:99064831 C4orf37 0.58 8.82 0.43 6.37e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs3857536 0.707 rs9345793 chr6:66929807 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.12 -0.32 2.7e-9 Blood trace element (Cu levels); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26039424 chr1:46154040 TMEM69 0.44 6.21 0.32 1.59e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4595586 0.525 rs12809307 chr12:39365927 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.17 0.37 4.71e-12 Morning vs. evening chronotype; LUSC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.58 0.34 1.86e-10 Lung cancer; LUSC cis rs738322 0.646 rs132972 chr22:38562056 T/C cg25457927 chr22:38595422 NA -0.34 -6.92 -0.35 2.38e-11 Cutaneous nevi; LUSC cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg23029597 chr12:123009494 RSRC2 -0.6 -8.51 -0.42 5.83e-16 Body mass index; LUSC cis rs11155671 0.530 rs9397420 chr6:150206781 C/T cg13206674 chr6:150067644 NUP43 -0.42 -6.39 -0.33 5.62e-10 Testicular germ cell tumor; LUSC cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -7.46 -0.38 7.48e-13 Menarche (age at onset); LUSC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.22e-12 Extrinsic epigenetic age acceleration; LUSC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg13072238 chr3:49761600 GMPPB -0.71 -8.92 -0.44 3.03e-17 Menarche (age at onset); LUSC cis rs7119 0.634 rs11635634 chr15:77863412 T/C cg27398640 chr15:77910606 LINGO1 0.35 7.7 0.39 1.55e-13 Type 2 diabetes; LUSC trans rs1733410 0.504 rs11181874 chr12:37912890 C/A cg06521331 chr12:34319734 NA 0.4 6.32 0.33 8.45e-10 Morning vs. evening chronotype; LUSC cis rs4851254 0.660 rs13430705 chr2:100690616 G/A cg07810366 chr2:100720526 AFF3 -0.45 -6.06 -0.31 3.7e-9 Intelligence (multi-trait analysis); LUSC cis rs7246657 0.943 rs2112923 chr19:37940327 C/T cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6005807 0.668 rs60065194 chr22:28993756 A/G cg12565055 chr22:29076175 TTC28 0.56 5.97 0.31 6.06e-9 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2425143 0.822 rs6060677 chr20:34499368 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.58 5.9 0.31 8.9e-9 Blood protein levels; LUSC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -6.85 -0.35 3.53e-11 Cystic fibrosis severity; LUSC cis rs3824867 0.920 rs7126210 chr11:47460306 A/G cg20307385 chr11:47447363 PSMC3 0.65 9.66 0.47 1.27e-19 Mean corpuscular hemoglobin; LUSC cis rs6500395 0.890 rs9936445 chr16:48617754 T/G cg04672837 chr16:48644449 N4BP1 0.49 7.09 0.36 7.99e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1577917 0.682 rs1173419 chr6:86402163 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -9.52 -0.46 3.58e-19 Response to antipsychotic treatment; LUSC cis rs4566357 1.000 rs2177597 chr2:227922546 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.76 -0.3 1.87e-8 Coronary artery disease; LUSC cis rs3931020 0.688 rs1051122 chr1:75190452 C/T cg21535942 chr1:75199100 CRYZ;TYW3 0.46 5.81 0.3 1.48e-8 Resistin levels; LUSC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg14541582 chr5:601475 NA -0.37 -5.71 -0.3 2.48e-8 Lung disease severity in cystic fibrosis; LUSC cis rs7927771 0.839 rs59360790 chr11:47669175 T/C cg18512352 chr11:47633146 NA -0.44 -9.55 -0.46 2.81e-19 Subjective well-being; LUSC trans rs853679 0.607 rs66868086 chr6:27865902 A/T cg09904177 chr6:26538194 HMGN4 -0.82 -5.95 -0.31 6.72e-9 Depression; LUSC cis rs7789940 0.904 rs6953281 chr7:75946943 C/T cg15798862 chr7:76129360 DTX2 -0.47 -7.67 -0.39 1.92e-13 Multiple sclerosis; LUSC cis rs314370 0.570 rs314314 chr7:100423841 C/T cg10426581 chr7:100472382 SRRT 0.52 8.14 0.41 8.04e-15 Resting heart rate; LUSC cis rs868036 0.718 rs16951275 chr15:68077168 T/C cg08079166 chr15:68083412 MAP2K5 0.41 7.5 0.38 5.85e-13 Restless legs syndrome; LUSC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg10523679 chr1:76189770 ACADM 0.86 11.24 0.52 4.32e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -8.05 -0.4 1.5e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg24642439 chr20:33292090 TP53INP2 0.69 10.48 0.5 2.15e-22 Coronary artery disease; LUSC cis rs6076065 0.748 rs6137933 chr20:23383103 A/T cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs7296418 0.663 rs11057284 chr12:123830692 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.39 -0.33 5.72e-10 Platelet count; LUSC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg17724175 chr1:150552817 MCL1 0.37 6.63 0.34 1.37e-10 Tonsillectomy; LUSC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg04727924 chr7:799746 HEATR2 -0.56 -6.65 -0.34 1.23e-10 Cerebrospinal P-tau181p levels; LUSC cis rs9549260 0.753 rs9549243 chr13:41217205 G/A cg21288729 chr13:41239152 FOXO1 0.57 6.32 0.33 8.37e-10 Red blood cell count; LUSC cis rs7605827 0.930 rs6761904 chr2:15599658 A/G cg19274914 chr2:15703543 NA 0.46 8.8 0.43 7.47e-17 Educational attainment (years of education); LUSC cis rs757278 0.552 rs6943317 chr7:117313645 C/T cg10524701 chr7:117356490 CTTNBP2 0.4 5.75 0.3 1.99e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs10986311 0.814 rs12379417 chr9:127029736 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.36 5.68 0.3 2.91e-8 Vitiligo; LUSC trans rs970548 0.688 rs10900228 chr10:46082128 A/G cg14222797 chr10:16859974 RSU1 -0.57 -6.04 -0.31 4.07e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg09323728 chr8:95962352 TP53INP1 -0.3 -5.69 -0.3 2.78e-8 Type 2 diabetes; LUSC cis rs7799006 0.929 rs35791351 chr7:2269248 C/T cg02951883 chr7:2050386 MAD1L1 -0.36 -6.26 -0.32 1.17e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8072100 0.840 rs9900360 chr17:45491979 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.84 -0.3 1.22e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg13531842 chr10:38383804 ZNF37A -0.45 -7.08 -0.36 8.53e-12 Extrinsic epigenetic age acceleration; LUSC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg18876405 chr7:65276391 NA -0.55 -8.62 -0.43 2.67e-16 Aortic root size; LUSC cis rs4594175 0.926 rs10873044 chr14:51615856 T/C cg23942311 chr14:51606299 NA 0.31 6.07 0.32 3.39e-9 Cancer; LUSC cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg18252515 chr7:66147081 NA -1.21 -13.88 -0.6 6.79e-35 Diabetic kidney disease; LUSC cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg24296786 chr1:45957014 TESK2 0.5 6.9 0.35 2.61e-11 Red blood cell count;Reticulocyte count; LUSC cis rs807669 0.903 rs1018764 chr22:19172006 T/C cg02655711 chr22:19163373 SLC25A1 0.9 17.93 0.7 7.5400000000000006e-51 Metabolite levels; LUSC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs4243830 0.522 rs11122086 chr1:6601246 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.84 -10.24 -0.49 1.35e-21 Body mass index; LUSC cis rs9916302 0.660 rs4795379 chr17:37674683 T/G cg07936489 chr17:37558343 FBXL20 -0.82 -9.82 -0.47 3.65e-20 Glomerular filtration rate (creatinine); LUSC cis rs6489882 0.836 rs7967461 chr12:113369759 G/C cg20102336 chr12:113376681 OAS3 -0.42 -6.13 -0.32 2.44e-9 Chronic lymphocytic leukemia; LUSC cis rs17539620 0.624 rs871069 chr6:154837578 A/C cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC trans rs1005277 0.522 rs289649 chr10:37975384 T/C cg17830980 chr10:43048298 ZNF37B -0.4 -6.39 -0.33 5.47e-10 Extrinsic epigenetic age acceleration; LUSC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg16545954 chr1:2118288 C1orf86 -0.41 -7.83 -0.39 6.64e-14 Height; LUSC cis rs1348850 0.567 rs3770005 chr2:178528874 A/G cg22681709 chr2:178499509 PDE11A -0.58 -11.82 -0.54 3.66e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg16624210 chr5:671434 TPPP 0.48 6.35 0.33 7.13e-10 Obesity-related traits; LUSC trans rs9329221 0.509 rs3088186 chr8:10226355 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.81 0.35 4.68e-11 Neuroticism; LUSC cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg17063962 chr7:91808500 NA 0.58 9.34 0.46 1.35e-18 Breast cancer; LUSC cis rs10992471 0.528 rs1535754 chr9:95201917 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.42 -0.33 4.58e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7903847 0.620 rs11189168 chr10:99125769 T/C cg08345082 chr10:99160200 RRP12 -0.37 -7.31 -0.37 1.97e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs1348850 0.632 rs10167783 chr2:178519041 G/A cg22681709 chr2:178499509 PDE11A -0.59 -11.89 -0.55 2.07e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs11098499 0.865 rs9996417 chr4:120295862 T/C cg25214090 chr10:38739885 LOC399744 0.56 8.09 0.4 1.08e-14 Corneal astigmatism; LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg25036284 chr2:26402008 FAM59B 0.68 9.07 0.44 1.01e-17 Gut microbiome composition (summer); LUSC trans rs1973993 0.691 rs1980684 chr1:96890636 A/G cg10631902 chr5:14652156 NA 0.6 10.73 0.51 2.8e-23 Weight; LUSC cis rs2762353 0.935 rs1165153 chr6:25817789 A/G cg03264133 chr6:25882463 NA -0.44 -7.73 -0.39 1.28e-13 Blood metabolite levels; LUSC cis rs5758511 0.508 rs58099562 chr22:42453772 T/C cg00645731 chr22:42541494 CYP2D7P1 0.51 8.04 0.4 1.53e-14 Birth weight; LUSC cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg09975044 chr14:104007538 NA -0.36 -5.68 -0.3 2.92e-8 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.626 rs62260723 chr3:49872124 T/C cg03060546 chr3:49711283 APEH -0.61 -7.18 -0.37 4.46e-12 Menarche (age at onset); LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg13560548 chr3:10150139 C3orf24 0.53 7.43 0.38 9.1e-13 Alzheimer's disease; LUSC cis rs1403694 0.515 rs1648700 chr3:186449916 C/T cg12454167 chr3:186435060 KNG1 -0.28 -7.47 -0.38 6.92e-13 Blood protein levels; LUSC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg22875332 chr1:76189707 ACADM -0.87 -14.34 -0.62 1.11e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7903847 0.642 rs7092350 chr10:99140218 A/T cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.51e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs9467711 0.606 rs9393713 chr6:26373678 C/T cg09904177 chr6:26538194 HMGN4 -0.68 -6.55 -0.34 2.18e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4906332 0.834 rs12882130 chr14:103878774 C/G cg04998671 chr14:104000505 TRMT61A -0.41 -6.29 -0.33 9.69e-10 Coronary artery disease; LUSC cis rs10193935 0.792 rs222472 chr2:42662911 C/T cg27598129 chr2:42591480 NA -0.58 -7.98 -0.4 2.4e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs727505 0.826 rs11532793 chr7:124747952 A/G cg23710748 chr7:124431027 NA -0.4 -7.01 -0.36 1.34e-11 Lewy body disease; LUSC cis rs17030434 0.953 rs10010787 chr4:154692059 G/A cg14289246 chr4:154710475 SFRP2 -0.48 -6.39 -0.33 5.42e-10 Electrocardiographic conduction measures; LUSC trans rs853679 1.000 rs11965538 chr6:28239915 G/A cg06606381 chr12:133084897 FBRSL1 -0.56 -6.55 -0.34 2.16e-10 Depression; LUSC cis rs9399401 0.925 rs2294764 chr6:142737504 G/A cg03128060 chr6:142623767 GPR126 0.33 6.15 0.32 2.22e-9 Chronic obstructive pulmonary disease; LUSC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6906287 0.631 rs9320665 chr6:118986309 G/A cg21191810 chr6:118973309 C6orf204 0.32 6.05 0.31 3.83e-9 Electrocardiographic conduction measures; LUSC cis rs10886558 0.662 rs10886556 chr10:121757792 A/T cg02041677 chr10:121771263 NA -0.34 -5.8 -0.3 1.56e-8 Shingles; LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg01516881 chr6:292596 DUSP22 0.51 7.74 0.39 1.21e-13 Menopause (age at onset); LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03951724 chr22:30723125 TBC1D10A -0.48 -6.52 -0.34 2.57e-10 Bipolar disorder and schizophrenia; LUSC trans rs1005277 0.579 rs176886 chr10:38403974 C/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.65 -0.47 1.39e-19 Extrinsic epigenetic age acceleration; LUSC cis rs72634258 0.554 rs4908699 chr1:7905274 G/A cg26816564 chr1:7831052 VAMP3 0.94 13.17 0.58 3.49e-32 Inflammatory bowel disease; LUSC cis rs9394152 0.845 rs7743060 chr6:33470519 C/T cg13560919 chr6:33536144 NA 0.61 10.72 0.51 3.04e-23 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs12989701 0.877 rs34745987 chr2:127875384 C/T cg08168897 chr2:127865431 BIN1 0.73 9.38 0.46 1e-18 Alzheimer's disease (late onset); LUSC cis rs6142102 0.961 rs6120487 chr20:32622608 A/G cg08999081 chr20:33150536 PIGU 0.34 5.86 0.31 1.08e-8 Skin pigmentation; LUSC cis rs11971779 0.616 rs6467836 chr7:139023517 C/G cg07862535 chr7:139043722 LUC7L2 0.54 6.7 0.34 9.08e-11 Diisocyanate-induced asthma; LUSC cis rs7107174 1.000 rs10899495 chr11:78123293 C/T cg02023728 chr11:77925099 USP35 0.44 6.41 0.33 5.01e-10 Testicular germ cell tumor; LUSC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg25554036 chr4:6271136 WFS1 0.55 11.42 0.53 9.75e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4356932 0.790 rs6532130 chr4:76969190 A/G cg00809888 chr4:76862425 NAAA 0.34 5.68 0.3 2.94e-8 Blood protein levels; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.1e-30 Aortic root size; LUSC cis rs4666002 0.636 rs13023194 chr2:27967260 G/C cg27432699 chr2:27873401 GPN1 0.49 5.72 0.3 2.37e-8 Phospholipid levels (plasma); LUSC cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg26384229 chr12:38710491 ALG10B 0.79 12.94 0.58 2.49e-31 Bladder cancer; LUSC cis rs7173743 0.756 rs4551997 chr15:79130433 G/A cg00540400 chr15:79124168 NA 0.36 6.2 0.32 1.7e-9 Coronary artery disease; LUSC cis rs6977660 0.714 rs12386623 chr7:19791875 A/G cg07541023 chr7:19748670 TWISTNB -0.66 -7.09 -0.36 7.8e-12 Thyroid stimulating hormone; LUSC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg13939156 chr17:80058883 NA 0.33 6.42 0.33 4.73e-10 Life satisfaction; LUSC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC trans rs8072100 0.701 rs2013383 chr17:45791123 T/G cg03886242 chr7:26192032 NFE2L3 -0.42 -6.48 -0.33 3.25e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3806843 0.931 rs13168670 chr5:140146899 T/C cg19875535 chr5:140030758 IK 0.49 7.91 0.4 3.76e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs4132509 0.793 rs74379351 chr1:243779604 T/C cg21452805 chr1:244014465 NA 0.64 6.15 0.32 2.19e-9 RR interval (heart rate); LUSC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs10465746 0.775 rs4907186 chr1:84340753 G/T cg10977910 chr1:84465055 TTLL7 0.53 7.57 0.38 3.76e-13 Obesity-related traits; LUSC cis rs738321 0.790 rs4820317 chr22:38543287 T/C cg25457927 chr22:38595422 NA -0.36 -7.01 -0.36 1.37e-11 Breast cancer; LUSC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg08048268 chr3:133502702 NA -0.47 -9.09 -0.45 8.77e-18 Iron status biomarkers; LUSC cis rs17253792 0.822 rs117050012 chr14:56038729 G/T cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg25456477 chr12:86230367 RASSF9 0.44 7.87 0.4 4.98e-14 Major depressive disorder; LUSC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg12463550 chr7:65579703 CRCP -0.44 -6.56 -0.34 2.01e-10 Aortic root size; LUSC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg26039829 chr8:22132926 PIWIL2 0.44 8.13 0.41 8.7e-15 Hypertriglyceridemia; LUSC cis rs11122272 0.735 rs2486740 chr1:231517552 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs735539 1.000 rs6490606 chr13:21285096 C/G cg04906043 chr13:21280425 IL17D 0.45 8.68 0.43 1.74e-16 Dental caries; LUSC cis rs7523050 0.643 rs36047249 chr1:109401499 T/C cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs8032315 0.965 rs1894400 chr15:91428955 C/T cg04510874 chr15:91427884 FES 0.31 6.13 0.32 2.49e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg07716408 chr11:68623521 NA 0.31 6.05 0.31 3.95e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs78663649 0.614 rs76626935 chr19:16581375 T/C cg10248733 chr19:16607483 C19orf44;CALR3 -0.94 -6.45 -0.33 3.95e-10 White blood cell count; LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg05368731 chr17:41323189 NBR1 0.93 16.21 0.66 5.46e-44 Menopause (age at onset); LUSC cis rs1595825 1.000 rs74935794 chr2:198871195 T/G cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg13560548 chr3:10150139 C3orf24 0.49 6.93 0.35 2.13e-11 Alzheimer's disease; LUSC cis rs7131987 0.650 rs7301398 chr12:29455390 G/T cg09582351 chr12:29534625 ERGIC2 -0.32 -6.51 -0.34 2.71e-10 QT interval; LUSC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg00784671 chr22:46762841 CELSR1 -0.48 -6.53 -0.34 2.42e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs11098499 0.954 rs11722872 chr4:120233030 G/C cg09307838 chr4:120376055 NA 0.79 11.16 0.52 8.65e-25 Corneal astigmatism; LUSC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.44e-8 Extrinsic epigenetic age acceleration; LUSC cis rs11148252 0.553 rs7999849 chr13:53249414 A/G cg02158880 chr13:53174818 NA 0.56 9.83 0.47 3.44e-20 Lewy body disease; LUSC cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.57 -0.42 3.88e-16 Body mass index; LUSC cis rs12474201 0.928 rs1109380 chr2:46924490 G/T cg06386533 chr2:46925753 SOCS5 0.8 12.37 0.56 3.42e-29 Height; LUSC trans rs7824557 0.767 rs10104728 chr8:11171300 A/G cg06636001 chr8:8085503 FLJ10661 0.54 8.3 0.41 2.67e-15 Retinal vascular caliber; LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg00149659 chr3:10157352 C3orf10 0.93 11.87 0.54 2.29e-27 Alzheimer's disease; LUSC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg18252515 chr7:66147081 NA -1.2 -13.79 -0.6 1.55e-34 Diabetic kidney disease; LUSC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg03709012 chr19:19516395 GATAD2A 0.78 12.01 0.55 7.22e-28 Tonsillectomy; LUSC cis rs1475911 1.000 rs17114359 chr21:43510437 A/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.66 9.51 0.46 3.86e-19 IgG glycosylation; LUSC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg03161606 chr19:29218774 NA 0.6 8.81 0.43 7.07e-17 Methadone dose in opioid dependence; LUSC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg09796270 chr17:17721594 SREBF1 -0.41 -7.03 -0.36 1.16e-11 Total body bone mineral density; LUSC cis rs4144743 1.000 rs3809862 chr17:45330428 C/T cg18085866 chr17:45331354 ITGB3 -0.74 -7.72 -0.39 1.38e-13 Body mass index; LUSC cis rs9399135 0.967 rs9389258 chr6:135361140 T/C cg22676075 chr6:135203613 NA 0.47 7.33 0.37 1.72e-12 Red blood cell count; LUSC cis rs791888 0.723 rs1980648 chr10:89422369 T/C cg13926569 chr10:89418898 PAPSS2 0.36 7.1 0.36 7.63e-12 Magnesium levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26016210 chr1:156426331 NA 0.46 6.47 0.33 3.57e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4692589 0.540 rs1904823 chr4:170956772 C/T cg19918862 chr4:170955249 NA 0.35 6.3 0.33 9.43e-10 Anxiety disorder; LUSC cis rs73206853 0.563 rs16940992 chr12:111207515 C/T cg12870014 chr12:110450643 ANKRD13A -0.59 -7.78 -0.39 9.38e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs262150 0.659 rs2730275 chr7:158793397 A/G cg19418458 chr7:158789849 NA -0.64 -10.5 -0.5 1.83e-22 Facial morphology (factor 20); LUSC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg03678062 chr6:149772716 ZC3H12D 0.3 6.13 0.32 2.45e-9 Dupuytren's disease; LUSC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1891275 0.508 rs7099557 chr10:93445364 C/G cg07889827 chr10:93443413 NA -0.38 -8.48 -0.42 7.42e-16 Intelligence (multi-trait analysis); LUSC cis rs12530134 0.523 rs7762088 chr6:170794570 T/C cg16453901 chr6:170730693 NA -0.95 -6.14 -0.32 2.35e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3736594 0.513 rs6704596 chr2:27796927 A/G cg27432699 chr2:27873401 GPN1 0.66 8.89 0.44 3.99e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs79057730 0.684 rs6955004 chr7:790792 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.73 7.43 0.38 9.31e-13 Initial pursuit acceleration; LUSC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg00071950 chr4:10020882 SLC2A9 0.51 8.44 0.42 9.98e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6489882 0.867 rs4767036 chr12:113369177 T/G cg20102336 chr12:113376681 OAS3 -0.42 -6.13 -0.32 2.44e-9 Chronic lymphocytic leukemia; LUSC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg00074818 chr8:8560427 CLDN23 0.6 9.86 0.47 2.72e-20 Obesity-related traits; LUSC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg01448562 chr3:133502909 NA -0.74 -12.56 -0.57 6.48e-30 Iron status biomarkers; LUSC trans rs4689592 0.503 rs11937667 chr4:7057037 C/G cg07817883 chr1:32538562 TMEM39B 0.61 6.31 0.33 8.99e-10 Monocyte percentage of white cells; LUSC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.8 0.35 4.84e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs56307353 0.753 rs62129495 chr19:1962789 T/C cg11709110 chr19:1989583 BTBD2 -0.33 -5.68 -0.3 2.98e-8 Coronary artery disease; LUSC cis rs644799 0.525 rs3016206 chr11:95536724 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.87 13.48 0.59 2.22e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2692947 0.770 rs6719831 chr2:96502590 A/C cg23100626 chr2:96804247 ASTL 0.26 6.47 0.33 3.52e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9517320 1.000 rs9645890 chr13:99126637 C/T cg20487152 chr13:99095054 FARP1 0.34 6.38 0.33 5.98e-10 Longevity; LUSC cis rs400736 0.930 rs442862 chr1:8079494 T/C cg25007680 chr1:8021821 PARK7 0.57 9.11 0.45 7.79e-18 Response to antidepressants and depression; LUSC cis rs7180079 1.000 rs8029682 chr15:64628534 C/T cg02848875 chr15:64387786 SNX1 0.41 5.84 0.3 1.27e-8 Monocyte count; LUSC trans rs7824557 0.583 rs2736306 chr8:11239762 A/T cg15556689 chr8:8085844 FLJ10661 0.46 6.77 0.35 5.67e-11 Retinal vascular caliber; LUSC trans rs1015291 0.708 rs2638435 chr12:19999520 C/T cg01501474 chr7:55323552 NA -0.44 -5.94 -0.31 7e-9 Diastolic blood pressure; LUSC cis rs11229555 0.834 rs7925560 chr11:58263036 G/A cg15696309 chr11:58395628 NA -0.71 -9.05 -0.44 1.17e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2292884 0.505 rs78063959 chr2:238428961 G/A cg16989719 chr2:238392110 NA -0.44 -6.14 -0.32 2.33e-9 Prostate cancer; LUSC cis rs6500395 1.000 rs904819 chr16:48622583 C/A cg04672837 chr16:48644449 N4BP1 0.5 7.42 0.38 9.53e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg05025164 chr4:1340916 KIAA1530 0.44 6.87 0.35 3.13e-11 Obesity-related traits; LUSC trans rs12200782 1.000 rs6456742 chr6:26617075 T/C cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg11764359 chr7:65958608 NA 0.51 6.6 0.34 1.58e-10 Aortic root size; LUSC cis rs1949733 0.598 rs869602 chr4:8535371 G/T cg11789530 chr4:8429930 ACOX3 -0.44 -6.55 -0.34 2.12e-10 Response to antineoplastic agents; LUSC cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.49 -0.73 4.84e-57 Height; LUSC cis rs4722404 0.592 rs13221367 chr7:3119823 C/T cg19214707 chr7:3157722 NA -0.4 -6.78 -0.35 5.33e-11 Atopic dermatitis; LUSC cis rs6845621 0.899 rs6812302 chr4:18893038 G/A cg12196642 chr4:18937545 NA -0.31 -5.85 -0.3 1.19e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.15 -0.36 5.57e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7582720 1.000 rs72936862 chr2:203786812 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg08045932 chr20:61659980 NA 0.57 9.88 0.48 2.38e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs7106204 0.609 rs11825384 chr11:24285137 G/T ch.11.24196551F chr11:24239977 NA 0.72 6.07 0.31 3.57e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg02782426 chr3:40428986 ENTPD3 0.43 7.98 0.4 2.31e-14 Renal cell carcinoma; LUSC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.49 0.33 3.05e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -8.49 -0.42 7.07e-16 Lymphocyte counts; LUSC trans rs7824557 0.628 rs11994376 chr8:11202960 G/A cg15556689 chr8:8085844 FLJ10661 0.49 7.22 0.37 3.64e-12 Retinal vascular caliber; LUSC cis rs7552167 0.925 rs11249021 chr1:24512881 G/T cg01960748 chr1:24522592 NA -0.69 -10.8 -0.51 1.56e-23 Psoriasis vulgaris; LUSC cis rs1322512 0.834 rs2623984 chr6:152948615 A/C cg27316956 chr6:152958899 SYNE1 -0.36 -5.97 -0.31 5.91e-9 Tonometry; LUSC trans rs3857536 0.740 rs9354391 chr6:66890183 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.44 6.2 0.32 1.71e-9 Blood trace element (Cu levels); LUSC cis rs459571 0.959 rs455381 chr9:136905577 C/A cg01294253 chr9:136912663 BRD3 0.33 5.66 0.3 3.3e-8 Platelet distribution width; LUSC cis rs1801251 0.778 rs2675967 chr2:233736133 C/G cg08000102 chr2:233561755 GIGYF2 -0.47 -7.06 -0.36 9.41e-12 Coronary artery disease; LUSC cis rs701145 0.585 rs1713853 chr3:153795595 A/G cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs950027 0.620 rs2461700 chr15:45640627 T/C cg04036182 chr15:45458818 NA 0.34 5.7 0.3 2.6e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg12219531 chr12:120966889 COQ5 0.6 8.27 0.41 3.31e-15 High light scatter reticulocyte count; LUSC cis rs11971779 0.648 rs6946113 chr7:139106126 A/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6570726 0.516 rs9322025 chr6:145729196 C/T cg23711669 chr6:146136114 FBXO30 0.45 7.01 0.36 1.29e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.529 rs56153385 chr20:30187609 C/T cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.2e-10 Mean corpuscular hemoglobin; LUSC cis rs2562456 0.876 rs7252585 chr19:21657943 C/T cg00806126 chr19:22604979 ZNF98 0.41 6.57 0.34 1.96e-10 Pain; LUSC cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg08873628 chr1:175162347 KIAA0040 0.39 5.66 0.3 3.23e-8 Alcohol dependence; LUSC cis rs7246967 0.673 rs6511383 chr19:22956900 C/T cg23217946 chr19:22817039 ZNF492 0.43 5.85 0.3 1.16e-8 Bronchopulmonary dysplasia; LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg27170947 chr2:26402098 FAM59B -0.72 -10.98 -0.51 3.76e-24 Gut microbiome composition (summer); LUSC trans rs9951602 0.850 rs56367211 chr18:76677563 G/T cg02800362 chr5:177631904 HNRNPAB -0.59 -6.77 -0.35 5.76e-11 Obesity-related traits; LUSC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg21665744 chr7:39171113 POU6F2 0.48 7.68 0.39 1.73e-13 IgG glycosylation; LUSC cis rs34421088 0.560 rs2248315 chr8:11397086 T/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.88 -0.31 9.81e-9 Neuroticism; LUSC cis rs7605827 0.930 rs3815597 chr2:15625404 T/C cg19274914 chr2:15703543 NA 0.47 8.99 0.44 1.94e-17 Educational attainment (years of education); LUSC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 7.5 0.38 5.87e-13 Schizophrenia; LUSC trans rs6502050 0.667 rs9892469 chr17:80093657 T/C cg07393940 chr7:158741817 NA 0.38 6.88 0.35 2.93e-11 Life satisfaction; LUSC cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg27087555 chr16:88793112 FAM38A -1.42 -17.26 -0.69 3.56e-48 Plateletcrit; LUSC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg02269571 chr22:50332266 NA 0.59 8.71 0.43 1.44e-16 Schizophrenia; LUSC trans rs11700980 1.000 rs59580249 chr21:30129226 A/C cg05609335 chr17:75789393 NA 0.4 6.13 0.32 2.44e-9 QRS complex (12-leadsum); LUSC cis rs10751667 0.666 rs10902247 chr11:953686 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.07e-10 Alzheimer's disease (late onset); LUSC cis rs6430585 0.583 rs3769008 chr2:136586183 C/T cg07169764 chr2:136633963 MCM6 1.15 17.44 0.69 6.87e-49 Corneal structure; LUSC cis rs4700695 0.719 rs27084 chr5:65435286 G/A cg21114390 chr5:65439923 SFRS12 -0.62 -8.74 -0.43 1.12e-16 Facial morphology (factor 19); LUSC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg20203395 chr5:56204925 C5orf35 -0.74 -10.1 -0.48 4.21e-21 Initial pursuit acceleration; LUSC cis rs7589728 0.748 rs3791357 chr2:88478664 C/T cg04511125 chr2:88470314 THNSL2 0.74 6.87 0.35 3.06e-11 Plasma clusterin levels; LUSC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7119 0.717 rs12909645 chr15:77816819 A/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs1034435 0.755 rs5768681 chr22:48894501 C/T cg05992904 chr22:48892994 FAM19A5 -0.4 -8.03 -0.4 1.63e-14 Late-onset Alzheimer's disease; LUSC cis rs6543140 0.964 rs6761350 chr2:103030776 A/G cg09003973 chr2:102972529 NA 0.57 7.44 0.38 8.7e-13 Blood protein levels; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC cis rs11785400 0.928 rs2280878 chr8:143722366 G/A cg10596483 chr8:143751796 JRK 0.61 9.26 0.45 2.64e-18 Schizophrenia; LUSC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC trans rs3733585 0.654 rs4447863 chr4:9938969 T/C cg26043149 chr18:55253948 FECH -0.46 -7.03 -0.36 1.14e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6964587 0.967 rs17164315 chr7:91659150 C/G cg22117172 chr7:91764530 CYP51A1 0.31 5.7 0.3 2.7e-8 Breast cancer; LUSC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg15468180 chr1:107600409 PRMT6 0.37 5.7 0.3 2.67e-8 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg06484146 chr7:12443880 VWDE -0.63 -7.41 -0.38 1.07e-12 Coronary artery disease; LUSC cis rs7296418 0.663 rs4553407 chr12:123750748 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.47 -0.33 3.53e-10 Platelet count; LUSC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.86 11.48 0.53 6.11e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg24675658 chr1:53192096 ZYG11B -0.57 -8.84 -0.44 5.44e-17 Monocyte count; LUSC trans rs453301 0.506 rs686189 chr8:8623637 A/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.02 -0.31 4.54e-9 Joint mobility (Beighton score); LUSC cis rs12956009 0.583 rs12965907 chr18:44888455 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.14 0.32 2.36e-9 Educational attainment (years of education); LUSC cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg27129171 chr3:47204927 SETD2 -0.7 -11.62 -0.54 1.93e-26 Colorectal cancer; LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg22963979 chr7:1858916 MAD1L1 -0.55 -8.23 -0.41 4.16e-15 Bipolar disorder and schizophrenia; LUSC cis rs4566357 0.930 rs12621916 chr2:227923564 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs9487051 0.768 rs398944 chr6:109523444 T/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.79 -0.3 1.66e-8 Reticulocyte fraction of red cells; LUSC cis rs13315871 0.929 rs7628038 chr3:58313813 T/C cg12435725 chr3:58293450 RPP14 -0.71 -7.27 -0.37 2.62e-12 Cholesterol, total; LUSC cis rs950169 0.922 rs4842940 chr15:84831225 C/T cg17507749 chr15:85114479 UBE2QP1 -0.67 -8.67 -0.43 1.96e-16 Schizophrenia; LUSC cis rs12824058 0.831 rs7979497 chr12:130804706 C/T cg26677194 chr12:130822605 PIWIL1 0.56 8.39 0.42 1.4e-15 Menopause (age at onset); LUSC cis rs7705502 1.000 rs72812805 chr5:173344153 T/C cg18693985 chr5:173351052 CPEB4 -0.36 -5.7 -0.3 2.66e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs4786125 0.636 rs8062299 chr16:6902722 T/C cg03623568 chr16:6915990 A2BP1 -0.46 -7.62 -0.38 2.71e-13 Heart rate variability traits (SDNN); LUSC cis rs1775715 1.000 rs1775715 chr10:32309005 A/G cg04359828 chr10:32216031 ARHGAP12 -0.35 -5.84 -0.3 1.21e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg04166393 chr7:2884313 GNA12 -0.44 -5.99 -0.31 5.35e-9 Height; LUSC cis rs1577917 1.000 rs791856 chr6:86681841 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.43 6.24 0.32 1.31e-9 Response to antipsychotic treatment; LUSC cis rs79149102 0.579 rs7166105 chr15:75343942 A/G cg09165964 chr15:75287851 SCAMP5 0.85 8.21 0.41 4.84e-15 Lung cancer; LUSC cis rs4903214 0.895 rs1860716 chr14:74713273 T/A cg08255017 chr14:74727001 VSX2 -0.5 -6.82 -0.35 4.33e-11 Inflammatory bowel disease; LUSC cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg10207240 chr12:122356781 WDR66 -0.41 -5.98 -0.31 5.69e-9 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.4 -6.32 -0.33 8.6e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs713477 0.967 rs10483642 chr14:55920460 A/G cg04306507 chr14:55594613 LGALS3 0.3 6.03 0.31 4.46e-9 Pediatric bone mineral content (femoral neck); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg18539474 chr1:113933413 MAGI3 -0.44 -6.48 -0.33 3.28e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg26001750 chr1:26324559 PAFAH2 0.42 6.03 0.31 4.4e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg25554036 chr4:6271136 WFS1 -0.59 -11.93 -0.55 1.37e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.18 0.52 7.01e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9788682 0.642 rs2568483 chr15:78752343 A/G cg24631222 chr15:78858424 CHRNA5 0.62 8.36 0.42 1.68e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs5769765 0.908 rs56351880 chr22:50316597 A/G cg26441486 chr22:50317300 CRELD2 0.5 7.34 0.37 1.69e-12 Schizophrenia; LUSC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg02187348 chr16:89574699 SPG7 0.49 7.55 0.38 4.1e-13 Multiple myeloma (IgH translocation); LUSC cis rs1403694 0.695 rs5029970 chr3:186434491 T/C cg12454167 chr3:186435060 KNG1 0.34 8.44 0.42 9.55e-16 Blood protein levels; LUSC cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg20701182 chr2:24300061 SF3B14 0.88 11.42 0.53 1.05e-25 Lymphocyte counts; LUSC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg00784671 chr22:46762841 CELSR1 -0.48 -6.62 -0.34 1.41e-10 LDL cholesterol;Cholesterol, total; LUSC trans rs7843479 1.000 rs11775444 chr8:21813018 A/G cg10573190 chr2:85843190 USP39 -0.43 -6.11 -0.32 2.83e-9 Mean corpuscular volume; LUSC trans rs4332037 0.707 rs62435132 chr7:1891315 C/T cg10840412 chr1:235813424 GNG4 0.45 5.95 0.31 6.8e-9 Bipolar disorder; LUSC cis rs2073300 1.000 rs6137982 chr20:23468892 T/A cg09953122 chr20:23471693 CST8 -0.87 -6.99 -0.36 1.54e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg02475777 chr4:1388615 CRIPAK -0.47 -7.1 -0.36 7.71e-12 Obesity-related traits; LUSC cis rs9733 0.635 rs486836 chr1:150875967 A/T cg13175981 chr1:150552382 MCL1 0.44 6.21 0.32 1.55e-9 Tonsillectomy; LUSC cis rs208520 0.690 rs10455194 chr6:66743356 A/G cg07460842 chr6:66804631 NA 1.1 17.23 0.69 4.59e-48 Exhaled nitric oxide output; LUSC cis rs6565180 0.926 rs8046445 chr16:30386262 A/G cg17640201 chr16:30407289 ZNF48 -0.89 -16.8 -0.68 2.42e-46 Tonsillectomy; LUSC cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg16743903 chr16:89593216 SPG7 0.38 5.88 0.31 9.86e-9 Multiple myeloma (IgH translocation); LUSC cis rs9467711 0.606 rs34550936 chr6:26361985 A/G cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg10820045 chr2:198174542 NA -0.32 -5.85 -0.3 1.17e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg18758796 chr5:131593413 PDLIM4 -0.41 -6.47 -0.33 3.56e-10 Breast cancer; LUSC cis rs2348418 0.864 rs2137072 chr12:28716805 G/A cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs6754311 0.773 rs4988226 chr2:136610598 A/G cg07169764 chr2:136633963 MCM6 -0.6 -8.05 -0.4 1.47e-14 Mosquito bite size; LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg12564285 chr5:131593104 PDLIM4 0.56 10.76 0.51 2.22e-23 Acylcarnitine levels; LUSC cis rs977987 0.806 rs4888391 chr16:75400746 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.94 -0.36 2e-11 Dupuytren's disease; LUSC cis rs9473147 0.516 rs7749167 chr6:47493940 G/A cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs6456156 0.565 rs12529238 chr6:167465576 G/A cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC cis rs5758511 0.541 rs6002494 chr22:42199860 C/G cg00645731 chr22:42541494 CYP2D7P1 -0.39 -7.47 -0.38 7.22e-13 Birth weight; LUSC cis rs1801251 0.963 rs35362030 chr2:233612845 A/G cg08000102 chr2:233561755 GIGYF2 0.68 11.29 0.53 2.97e-25 Coronary artery disease; LUSC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg00343986 chr7:65444356 GUSB -0.4 -6.19 -0.32 1.79e-9 Cotinine glucuronidation; LUSC cis rs614226 0.935 rs588132 chr12:121024066 A/G cg01236616 chr12:121019343 POP5 1.31 21.4 0.76 1.34e-64 Type 1 diabetes nephropathy; LUSC trans rs149866169 1 rs149866169 chr6:27441723 T/A cg01620082 chr3:125678407 NA -0.69 -6.76 -0.35 6.15e-11 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; LUSC cis rs9788682 0.747 rs2656072 chr15:78744292 A/G cg24631222 chr15:78858424 CHRNA5 -0.64 -8.55 -0.42 4.48e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg04455712 chr21:45112962 RRP1B 0.46 8.54 0.42 4.85e-16 Mean corpuscular volume; LUSC cis rs2067615 0.579 rs10507214 chr12:107194461 G/A cg15890332 chr12:107067104 RFX4 0.34 6.18 0.32 1.91e-9 Heart rate; LUSC trans rs1459104 0.570 rs56152290 chr11:54858073 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.08 0.32 3.28e-9 Body mass index; LUSC cis rs9650315 0.733 rs13270845 chr8:57204188 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg06238570 chr21:40685208 BRWD1 -0.59 -9.16 -0.45 5.51e-18 Menarche (age at onset); LUSC cis rs10504229 0.679 rs16921677 chr8:58052431 T/C cg22535103 chr8:58192502 C8orf71 -0.57 -6.69 -0.34 9.59e-11 Developmental language disorder (linguistic errors); LUSC cis rs2281558 0.754 rs73597824 chr20:25591477 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.59 8.8 0.43 7.29e-17 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg25643088 chr3:52874325 TMEM110 0.4 6.06 0.31 3.7e-9 Schizophrenia; LUSC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg12463550 chr7:65579703 CRCP -0.52 -7.63 -0.39 2.42e-13 Aortic root size; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg22278056 chr19:44439434 NA 0.46 5.96 0.31 6.55e-9 Neuroticism; LUSC cis rs60843830 0.928 rs62114494 chr2:211317 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.62 9.88 0.48 2.28e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9303401 0.614 rs62084384 chr17:57126842 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.78 0.57 9.81e-31 Cognitive test performance; LUSC cis rs1971762 0.583 rs10876485 chr12:54087648 C/T cg23533419 chr12:54090519 NA 0.37 6.21 0.32 1.56e-9 Height; LUSC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg13114125 chr14:105738426 BRF1 -0.93 -16.05 -0.66 2.36e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs9467773 0.587 rs3208733 chr6:26414425 C/T cg05738196 chr6:26577821 NA -0.5 -7.4 -0.38 1.11e-12 Intelligence (multi-trait analysis); LUSC cis rs9929218 0.507 rs62057805 chr16:68742390 G/C cg01251360 chr16:68772225 CDH1 -0.25 -5.84 -0.3 1.24e-8 Colorectal cancer; LUSC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.65 -0.34 1.21e-10 Total body bone mineral density; LUSC cis rs2806561 0.577 rs488438 chr1:23498999 T/A cg12483005 chr1:23474871 LUZP1 0.4 5.98 0.31 5.77e-9 Height; LUSC cis rs1577917 0.958 rs72907388 chr6:86440207 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.5 -7.23 -0.37 3.32e-12 Response to antipsychotic treatment; LUSC cis rs7824557 0.527 rs2409756 chr8:11242025 A/C cg21775007 chr8:11205619 TDH -0.73 -11.15 -0.52 9.56e-25 Retinal vascular caliber; LUSC trans rs34421088 0.576 rs2736369 chr8:11101398 G/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.67 -0.34 1.04e-10 Neuroticism; LUSC cis rs12980942 0.591 rs4591267 chr19:41765407 A/C cg25627403 chr19:41769009 HNRNPUL1 0.69 7.27 0.37 2.61e-12 Coronary artery disease; LUSC cis rs765787 0.530 rs2413786 chr15:45525394 C/A cg25801113 chr15:45476975 SHF 0.34 7.08 0.36 8.49e-12 Uric acid levels; LUSC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg22800045 chr5:56110881 MAP3K1 0.8 10.45 0.5 2.68e-22 Initial pursuit acceleration; LUSC cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg16339924 chr4:17578868 LAP3 -0.52 -7.67 -0.39 1.94e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11098499 0.954 rs10005644 chr4:120298477 T/C cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs7712401 0.562 rs364723 chr5:122326464 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs6738485 0.507 rs66569888 chr2:106886967 G/A cg15412446 chr2:106886593 NA -0.52 -6.03 -0.31 4.26e-9 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; LUSC trans rs11700980 0.551 rs2832032 chr21:30114790 G/A cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC trans rs4596713 0.568 rs6560584 chr9:71747172 A/G cg25283916 chr1:242222868 NA -0.3 -6.14 -0.32 2.36e-9 Headache; LUSC cis rs6700896 0.500 rs4655564 chr1:66083537 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs2274273 0.870 rs10149420 chr14:55854257 T/C cg04306507 chr14:55594613 LGALS3 0.55 12.81 0.57 7.95e-31 Protein biomarker; LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg07507251 chr3:52567010 NT5DC2 0.34 6.68 0.34 1e-10 Bipolar disorder; LUSC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg24110177 chr3:50126178 RBM5 0.55 9.12 0.45 7.31e-18 Intelligence (multi-trait analysis); LUSC cis rs3764021 0.837 rs7306557 chr12:9877356 G/A cg20894963 chr12:9885564 CLECL1 0.35 7.1 0.36 7.47e-12 Type 1 diabetes; LUSC cis rs782590 0.935 rs2586954 chr2:55892261 A/C cg18811423 chr2:55921094 PNPT1 0.88 15.31 0.64 1.87e-40 Metabolic syndrome; LUSC cis rs2486288 0.656 rs12910009 chr15:45572408 A/G cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.9 -0.51 7.23e-24 Glomerular filtration rate; LUSC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.26 -0.32 1.16e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6489785 0.547 rs625228 chr12:121278266 G/A cg02419362 chr12:121203948 SPPL3 -0.39 -6.96 -0.36 1.85e-11 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs4363385 0.719 rs12748969 chr1:152932654 T/C cg07796016 chr1:152779584 LCE1C -0.46 -6.5 -0.34 2.85e-10 Inflammatory skin disease; LUSC cis rs7119 0.604 rs2682924 chr15:77863720 C/T cg27398640 chr15:77910606 LINGO1 -0.35 -7.75 -0.39 1.1e-13 Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18001866 chr11:33061388 TCP11L1 -0.41 -6.16 -0.32 2.09e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs56399783 0.901 rs73051469 chr7:2877811 A/G cg19731401 chr7:2775893 GNA12 0.7 9.38 0.46 1.03e-18 Childhood ear infection; LUSC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11644478 chr21:40555479 PSMG1 -0.82 -14.66 -0.63 6.74e-38 Cognitive function; LUSC cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg18681998 chr4:17616180 MED28 0.78 13.81 0.6 1.26e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs929596 0.556 rs10202865 chr2:234587707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.82 -0.39 6.82e-14 Total bilirubin levels in HIV-1 infection; LUSC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11890956 chr21:40555474 PSMG1 -0.9 -16.46 -0.67 5.61e-45 Cognitive function; LUSC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg24060327 chr5:131705240 SLC22A5 0.66 10.98 0.51 3.75e-24 Breast cancer; LUSC trans rs208520 0.661 rs704519 chr6:66801136 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.59 -0.69 1.73e-49 Exhaled nitric oxide output; LUSC cis rs3803170 0.513 rs7299142 chr12:111829513 G/A cg10833066 chr12:111807467 FAM109A 0.39 7.24 0.37 3.19e-12 Mean corpuscular hemoglobin; LUSC cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs710865 1.000 rs710866 chr1:19568722 G/C cg13387374 chr1:19411106 UBR4 0.43 6.24 0.32 1.34e-9 Brain structure; LUSC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg14004847 chr7:1930337 MAD1L1 -0.53 -7.85 -0.39 5.86e-14 Bipolar disorder and schizophrenia; LUSC cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg03146154 chr1:46216737 IPP -0.52 -7.45 -0.38 8.15e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7267979 1.000 rs2258879 chr20:25279213 T/C cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg21970626 chr13:21893289 NA -0.52 -9.55 -0.46 2.91e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs2730245 0.527 rs2657362 chr7:158685095 A/G cg11984989 chr7:158649758 WDR60 1.12 13.43 0.59 3.46e-33 Height; LUSC cis rs3820928 0.874 rs55748731 chr2:227818629 C/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.65 -0.39 2.11e-13 Pulmonary function; LUSC trans rs11992162 0.967 rs10112888 chr8:11830208 G/C cg15556689 chr8:8085844 FLJ10661 0.56 8.25 0.41 3.59e-15 Monocyte count; LUSC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg18230493 chr5:56204884 C5orf35 -0.92 -13.64 -0.6 5.77e-34 Initial pursuit acceleration; LUSC cis rs568617 1.000 rs694994 chr11:65653309 A/G cg19792802 chr11:65647270 CTSW 0.41 6.21 0.32 1.57e-9 Crohn's disease; LUSC cis rs9650657 0.737 rs2116095 chr8:10635297 T/C cg27411982 chr8:10470053 RP1L1 -0.42 -6.64 -0.34 1.29e-10 Neuroticism; LUSC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg27494647 chr7:150038898 RARRES2 0.46 6.91 0.35 2.52e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs11018904 0.861 rs4589254 chr11:89963355 A/C cg26834418 chr11:89957033 CHORDC1 0.47 6.04 0.31 4.16e-9 Intelligence (multi-trait analysis); LUSC cis rs16895831 0.519 rs61298049 chr6:42540394 T/G cg10605015 chr6:42532144 UBR2 -0.49 -5.94 -0.31 7.02e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs1506636 0.962 rs1472808 chr7:123354536 A/G cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.6 -0.43 3.2e-16 Personality dimensions; LUSC trans rs2727020 0.553 rs10839295 chr11:49527345 A/C cg15704280 chr7:45808275 SEPT13 -1.06 -20.13 -0.74 1.46e-59 Coronary artery disease; LUSC cis rs17270561 0.609 rs1165155 chr6:25795577 A/T cg16482183 chr6:26056742 HIST1H1C 0.53 7.53 0.38 4.66e-13 Iron status biomarkers; LUSC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg03388025 chr16:89894329 SPIRE2 0.31 6.47 0.33 3.52e-10 Vitiligo; LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.82 0.78 4.03e-70 Prudent dietary pattern; LUSC cis rs7119 0.635 rs907374 chr15:77884026 C/T cg27398640 chr15:77910606 LINGO1 0.36 8.41 0.42 1.2e-15 Type 2 diabetes; LUSC cis rs2274273 0.840 rs3742569 chr14:55818706 T/C cg04306507 chr14:55594613 LGALS3 0.53 11.56 0.53 3.15e-26 Protein biomarker; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22456132 chr7:66309881 LOC729156 -0.4 -5.99 -0.31 5.53e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9815354 0.767 rs111708447 chr3:41809583 G/A cg03022575 chr3:42003672 ULK4 0.83 8.34 0.41 2.04e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs10832963 0.686 rs11024743 chr11:18653712 A/G cg09201001 chr11:18656081 SPTY2D1 0.91 14.87 0.63 1e-38 Breast cancer; LUSC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg02807482 chr3:125708958 NA -0.53 -6.62 -0.34 1.46e-10 Blood pressure (smoking interaction); LUSC cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg06550200 chr5:1325588 CLPTM1L -0.67 -11.68 -0.54 1.17e-26 Lung cancer; LUSC cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg02153584 chr22:29168773 CCDC117 0.59 8.84 0.44 5.54e-17 Lymphocyte counts; LUSC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg06494592 chr3:125709126 NA -0.53 -6.03 -0.31 4.35e-9 Blood pressure (smoking interaction); LUSC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg10018233 chr7:150070692 REPIN1 0.33 6.02 0.31 4.53e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg00074818 chr8:8560427 CLDN23 0.57 9.88 0.48 2.27e-20 Obesity-related traits; LUSC cis rs6429082 0.818 rs291391 chr1:235649955 A/G cg26050004 chr1:235667680 B3GALNT2 0.61 8.33 0.41 2.06e-15 Adiposity; LUSC cis rs7617480 0.648 rs9864243 chr3:48982732 G/A cg21141812 chr3:48556323 PFKFB4 0.35 6.24 0.32 1.32e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg00999904 chr2:3704751 ALLC 0.46 7.09 0.36 8.04e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 12.62 0.57 3.95e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs320035 0.605 rs319957 chr1:49112458 G/A cg02479497 chr16:85548895 NA 0.28 6.05 0.31 3.94e-9 Liver injury in anti-tuberculosis drug treatment; LUSC cis rs6066835 1.000 rs6066835 chr20:47355009 A/G cg15609812 chr20:47281632 PREX1 0.56 5.73 0.3 2.27e-8 Multiple myeloma; LUSC cis rs713477 1.000 rs10782426 chr14:55890702 G/A cg04306507 chr14:55594613 LGALS3 -0.32 -6.33 -0.33 7.83e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs7605827 0.930 rs10201925 chr2:15528742 G/A cg19274914 chr2:15703543 NA 0.45 8.76 0.43 1.02e-16 Educational attainment (years of education); LUSC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg27297192 chr10:134578999 INPP5A -0.37 -5.96 -0.31 6.48e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs34638657 0.872 rs7192444 chr16:82180338 C/G cg09439754 chr16:82129088 HSD17B2 0.37 5.91 0.31 8.22e-9 Lung adenocarcinoma; LUSC cis rs11155671 0.530 rs4869764 chr6:150211828 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg11266682 chr4:10021025 SLC2A9 0.57 10.75 0.51 2.46e-23 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8133932 0.654 rs369245 chr21:47337821 G/A cg14185626 chr21:47401492 COL6A1 -0.44 -5.68 -0.3 2.93e-8 Schizophrenia; LUSC cis rs11098499 0.954 rs10008459 chr4:120394231 T/C cg09307838 chr4:120376055 NA 0.79 11.5 0.53 5.34e-26 Corneal astigmatism; LUSC cis rs8141529 0.732 rs11556025 chr22:29168755 T/C cg15103426 chr22:29168792 CCDC117 0.57 7.52 0.38 5.05e-13 Lymphocyte counts; LUSC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12756686 chr19:29218302 NA 0.68 9.59 0.46 2.11e-19 Methadone dose in opioid dependence; LUSC cis rs859767 0.501 rs1123184 chr2:135431057 C/G cg12500956 chr2:135428796 TMEM163 -0.29 -6.89 -0.35 2.74e-11 Neuroticism; LUSC cis rs9987353 0.519 rs13276350 chr8:9063157 T/C cg15556689 chr8:8085844 FLJ10661 -0.43 -6.01 -0.31 4.75e-9 Recombination measurement; LUSC cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg23711669 chr6:146136114 FBXO30 0.74 13.2 0.59 2.66e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg00310523 chr12:86230176 RASSF9 -0.5 -9.56 -0.46 2.69e-19 Major depressive disorder; LUSC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg05623727 chr3:50126028 RBM5 0.33 6.08 0.32 3.22e-9 Body mass index; LUSC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg20243544 chr17:37824526 PNMT -0.46 -5.75 -0.3 2.06e-8 Glomerular filtration rate (creatinine); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18644618 chr3:101280570 RG9MTD1 -0.48 -6.11 -0.32 2.75e-9 Bipolar disorder and schizophrenia; LUSC cis rs9527 0.590 rs6584537 chr10:104778267 C/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.15e-10 Arsenic metabolism; LUSC cis rs9486715 0.867 rs3860243 chr6:96905303 T/G cg06623918 chr6:96969491 KIAA0776 0.93 17.54 0.69 2.88e-49 Headache; LUSC cis rs7572644 0.581 rs10205313 chr2:28176527 A/C cg27432699 chr2:27873401 GPN1 -0.52 -6.51 -0.34 2.83e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg20821713 chr7:1055600 C7orf50 -0.52 -6.78 -0.35 5.42e-11 Bronchopulmonary dysplasia; LUSC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg15147215 chr3:52552868 STAB1 -0.31 -6.2 -0.32 1.65e-9 Bipolar disorder; LUSC trans rs804280 0.509 rs10109241 chr8:11784985 A/T cg06636001 chr8:8085503 FLJ10661 0.54 7.96 0.4 2.77e-14 Myopia (pathological); LUSC cis rs10225163 0.590 rs10266923 chr7:27918229 C/T cg22168087 chr7:27702803 HIBADH -0.47 -7.17 -0.37 4.83e-12 Gout; LUSC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg13393036 chr8:95962371 TP53INP1 0.44 8.42 0.42 1.13e-15 Type 2 diabetes; LUSC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg08109568 chr15:31115862 NA -0.72 -10.65 -0.5 5.34e-23 Huntington's disease progression; LUSC cis rs701145 0.938 rs789380 chr3:154081424 G/A cg17054900 chr3:154042577 DHX36 0.8 8.0 0.4 2.13e-14 Coronary artery disease; LUSC cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg05868516 chr6:26286170 HIST1H4H -0.37 -6.24 -0.32 1.32e-9 Educational attainment; LUSC cis rs10203711 0.966 rs9287635 chr2:239582267 C/T cg14580085 chr2:239553406 NA 0.42 7.11 0.36 7.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2932538 0.961 rs3795820 chr1:113163042 C/A cg22162597 chr1:113214053 CAPZA1 -0.69 -9.82 -0.47 3.65e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg05872129 chr22:39784769 NA -0.59 -10.03 -0.48 7.18e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2281845 0.859 rs58364051 chr1:201077667 A/G cg22815214 chr1:201083145 CACNA1S 0.53 9.22 0.45 3.55e-18 Permanent tooth development; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg13453750 chr1:205783389 SLC41A1 -0.33 -6.45 -0.33 3.96e-10 Menarche (age at onset); LUSC trans rs961253 0.556 rs1571217 chr20:6316526 A/C cg21095983 chr6:86352623 SYNCRIP -0.44 -6.66 -0.34 1.12e-10 Colorectal cancer; LUSC cis rs7568458 0.846 rs6705971 chr2:85761417 G/T cg17127132 chr2:85788382 GGCX -0.44 -7.12 -0.36 6.55e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg13057898 chr1:3703894 LRRC47 0.48 8.4 0.42 1.34e-15 Red cell distribution width; LUSC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs3125734 0.633 rs10740068 chr10:63982254 A/C cg09941381 chr10:64027924 RTKN2 -0.39 -7.38 -0.37 1.25e-12 Rheumatoid arthritis; LUSC cis rs11958404 0.932 rs72816550 chr5:157418457 A/T cg05962755 chr5:157440814 NA 0.5 6.14 0.32 2.34e-9 IgG glycosylation; LUSC cis rs751728 1.000 rs4713684 chr6:33766488 T/C cg25922239 chr6:33757077 LEMD2 0.54 7.98 0.4 2.44e-14 Crohn's disease; LUSC cis rs10789491 1.000 rs618505 chr1:47144532 T/C cg15501359 chr1:47185051 KIAA0494 0.8 11.29 0.53 2.98e-25 Response to hepatitis C treatment; LUSC cis rs3755132 0.929 rs57670756 chr2:15753821 G/A cg12888861 chr2:15731646 DDX1 0.52 7.48 0.38 6.45e-13 Wilms tumor; LUSC cis rs668210 0.793 rs619701 chr11:65772080 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.59 -7.52 -0.38 4.99e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg00166722 chr3:10149974 C3orf24 0.62 8.79 0.43 8.13e-17 Alzheimer's disease; LUSC cis rs1570989 0.571 rs6916066 chr6:12016009 G/C cg17804551 chr6:12015979 HIVEP1 0.39 6.88 0.35 2.89e-11 Alcohol and nicotine co-dependence; LUSC cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.72 0.43 1.3e-16 Motion sickness; LUSC cis rs6494488 0.500 rs72744766 chr15:65079091 T/C cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs56346965 0.967 rs11900804 chr2:191533767 T/C cg11845111 chr2:191398756 TMEM194B -0.43 -6.3 -0.33 9.4e-10 Bone mineral density (Ward's triangle area); LUSC trans rs7615952 0.599 rs12496921 chr3:125701948 C/G cg07211511 chr3:129823064 LOC729375 -0.81 -10.63 -0.5 6.5e-23 Blood pressure (smoking interaction); LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg05025164 chr4:1340916 KIAA1530 0.39 5.74 0.3 2.18e-8 Obesity-related traits; LUSC cis rs722599 0.599 rs8003660 chr14:75227098 T/C cg08847533 chr14:75593920 NEK9 0.42 5.88 0.31 9.78e-9 IgG glycosylation; LUSC cis rs12545109 0.917 rs10098993 chr8:57323116 T/C cg09654669 chr8:57350985 NA -0.59 -7.9 -0.4 4.15e-14 Obesity-related traits; LUSC cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 28.99 0.85 3.21e-93 Chronic sinus infection; LUSC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.72 0.3 2.4e-8 Life satisfaction; LUSC cis rs17401966 0.894 rs12722830 chr1:10395134 A/G cg19773385 chr1:10388646 KIF1B -0.57 -9.79 -0.47 4.78e-20 Hepatocellular carcinoma; LUSC cis rs11779988 0.545 rs427168 chr8:17784829 G/A cg01800426 chr8:17659068 MTUS1 -0.5 -6.13 -0.32 2.54e-9 Breast cancer; LUSC cis rs11122272 0.735 rs2491407 chr1:231518928 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg03732007 chr1:2071316 PRKCZ -0.51 -9.13 -0.45 6.94e-18 Height; LUSC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg22535103 chr8:58192502 C8orf71 -0.73 -9.16 -0.45 5.46e-18 Developmental language disorder (linguistic errors); LUSC cis rs67517081 1 rs67517081 chr16:30987380 GT/G cg02466173 chr16:30829666 NA 0.55 10.76 0.51 2.3e-23 Mean corpuscular hemoglobin; LUSC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.52 10.25 0.49 1.3e-21 Monocyte percentage of white cells; LUSC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.72 -0.43 1.31e-16 Lung cancer; LUSC cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs9486719 0.857 rs13208321 chr6:96860354 C/T cg06623918 chr6:96969491 KIAA0776 -0.7 -10.15 -0.49 2.89e-21 Migraine;Coronary artery disease; LUSC cis rs2404618 0.587 rs6994849 chr8:1492839 G/T cg02903104 chr8:1507517 DLGAP2 -0.36 -6.7 -0.34 9.04e-11 Lung cancer; LUSC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg19622623 chr12:86230825 RASSF9 -0.45 -6.48 -0.33 3.26e-10 Major depressive disorder; LUSC cis rs2730245 0.592 rs2657385 chr7:158649373 A/G cg14689365 chr7:158441557 NCAPG2 0.54 7.87 0.4 5.12e-14 Height; LUSC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg09455208 chr3:40491958 NA 0.52 9.37 0.46 1.13e-18 Renal cell carcinoma; LUSC cis rs2302729 0.790 rs10505724 chr12:2782070 C/T cg19945202 chr12:2788847 CACNA1C -0.46 -6.3 -0.33 9.57e-10 Sleep quality; LUSC cis rs72634258 0.842 rs7545677 chr1:8165619 C/T cg00042356 chr1:8021962 PARK7 0.56 7.17 0.37 4.79e-12 Inflammatory bowel disease; LUSC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg10295955 chr4:187884368 NA 1.08 23.54 0.79 6.31e-73 Lobe attachment (rater-scored or self-reported); LUSC cis rs3790645 0.645 rs17162190 chr1:26872832 G/A cg17456097 chr1:26900765 RPS6KA1 0.5 6.55 0.34 2.12e-10 Glucose homeostasis traits; LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg10802521 chr3:52805072 NEK4 -0.58 -9.22 -0.45 3.34e-18 Bipolar disorder; LUSC cis rs17608059 0.679 rs9898056 chr17:13951966 C/G cg11395062 chr17:14139857 CDRT15 0.4 5.99 0.31 5.29e-9 Temperament; LUSC cis rs9902453 1.000 rs6505152 chr17:28331466 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.29 -0.41 2.71e-15 Coffee consumption (cups per day); LUSC cis rs7818345 0.967 rs11784873 chr8:19281113 A/G cg11303988 chr8:19266685 CSGALNACT1 0.38 7.32 0.37 1.87e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs4766566 0.609 rs933305 chr12:111738287 G/A cg10833066 chr12:111807467 FAM109A 0.51 8.9 0.44 3.57e-17 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg13535736 chr9:111863775 C9orf5 -0.42 -6.69 -0.34 9.51e-11 Menarche (age at onset); LUSC cis rs61935443 0.832 rs10859778 chr12:95268010 C/G cg21533806 chr12:95267307 NA 0.52 6.68 0.34 9.95e-11 Schizophrenia; LUSC cis rs4246215 1 rs4246215 chr11:61564299 G/T cg19610905 chr11:61596333 FADS2 -0.47 -6.82 -0.35 4.25e-11 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid);Platelet count;Inflammatory bowel disease;Trans fatty acid levels;Crohn's disease;Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid);Red blood cell fatty acid levels;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid); LUSC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11644478 chr21:40555479 PSMG1 -0.77 -13.54 -0.6 1.31e-33 Cognitive function; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26871885 chr11:207525 RIC8A;BET1L -0.53 -7.24 -0.37 3.06e-12 Bipolar disorder and schizophrenia; LUSC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg19592336 chr6:28129416 ZNF389 0.48 6.27 0.32 1.11e-9 Depression; LUSC cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg03146154 chr1:46216737 IPP 0.52 7.79 0.39 8.3e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg19539972 chr4:7069911 GRPEL1 0.7 8.83 0.43 6.23e-17 Monocyte percentage of white cells; LUSC cis rs7819412 0.505 rs17726209 chr8:11022185 C/T cg21775007 chr8:11205619 TDH 0.49 6.76 0.35 6.35e-11 Triglycerides; LUSC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg12311346 chr5:56204834 C5orf35 -0.61 -9.35 -0.46 1.32e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs317689 0.718 rs315130 chr12:69761444 T/C cg14784868 chr12:69753453 YEATS4 0.62 8.15 0.41 7.43e-15 Response to diuretic therapy; LUSC trans rs621942 0.635 rs12786057 chr11:85858417 C/T cg24608144 chr20:62398219 ZBTB46 0.4 6.06 0.31 3.75e-9 Tourette syndrome; LUSC cis rs8051431 0.876 rs4788589 chr16:72019948 A/T cg27261665 chr16:71265020 HYDIN 0.35 5.69 0.3 2.72e-8 LDL cholesterol levels; LUSC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg04315214 chr1:2043799 PRKCZ 0.47 9.53 0.46 3.39e-19 Height; LUSC cis rs6834538 0.597 rs6822451 chr4:113463265 G/A cg05166686 chr4:113558556 LARP7;C4orf21 0.36 5.82 0.3 1.37e-8 Free thyroxine concentration; LUSC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg06627628 chr2:24431161 ITSN2 -0.6 -7.21 -0.37 3.78e-12 Lymphocyte counts; LUSC cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg26384229 chr12:38710491 ALG10B 0.84 13.92 0.61 4.87e-35 Bladder cancer; LUSC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg00509249 chr6:109615579 CCDC162 -0.34 -6.09 -0.32 3.07e-9 Reticulocyte fraction of red cells; LUSC cis rs11122272 0.735 rs2011357 chr1:231480208 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -9.83 -0.47 3.33e-20 Hemoglobin concentration; LUSC cis rs11955175 1.000 rs79132719 chr5:40668525 T/C cg05478818 chr5:40835740 RPL37 0.7 5.7 0.3 2.65e-8 Bipolar disorder and schizophrenia; LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.51 0.65 3.1e-41 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21423973 chr7:72298667 TYW1B;SBDSP 0.42 6.06 0.31 3.67e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7568458 0.870 rs1009 chr2:85808737 A/G cg02493740 chr2:85810744 VAMP5 -0.33 -5.86 -0.31 1.12e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg18099408 chr3:52552593 STAB1 -0.42 -7.14 -0.36 6e-12 Bipolar disorder; LUSC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg05347473 chr6:146136440 FBXO30 0.59 9.69 0.47 9.73e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.545 rs74629553 chr16:68176415 C/A cg05110241 chr16:68378359 PRMT7 -0.64 -6.94 -0.36 1.99e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg27068330 chr11:65405492 SIPA1 -0.44 -5.8 -0.3 1.52e-8 Breast cancer; LUSC cis rs7771547 0.519 rs12206445 chr6:36379628 G/A cg07856975 chr6:36356162 ETV7 0.42 6.19 0.32 1.79e-9 Platelet distribution width; LUSC cis rs9815354 0.812 rs73073352 chr3:41842184 T/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg01802117 chr1:53393560 SCP2 -0.37 -5.95 -0.31 6.66e-9 Monocyte count; LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC trans rs2204008 0.774 rs11495520 chr12:38060605 T/G cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.25e-9 Bladder cancer; LUSC cis rs28595532 0.920 rs17325192 chr4:119780345 A/G cg21605333 chr4:119757512 SEC24D -1.04 -10.29 -0.49 9.12e-22 Cannabis dependence symptom count; LUSC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg07234876 chr8:600039 NA 0.86 8.85 0.44 5.13e-17 IgG glycosylation; LUSC cis rs7524258 0.867 rs35399313 chr1:7277293 T/C cg07173049 chr1:7289937 CAMTA1 0.33 6.82 0.35 4.41e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC trans rs1814175 0.781 rs1851872 chr11:50009770 A/G cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg02569458 chr12:86230093 RASSF9 0.48 7.63 0.39 2.55e-13 Major depressive disorder; LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg03538708 chr1:25844672 NA -0.35 -5.82 -0.3 1.38e-8 Erythrocyte sedimentation rate; LUSC cis rs17253792 0.822 rs79921041 chr14:56090779 T/C cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg24881330 chr22:46731750 TRMU 0.83 7.46 0.38 7.31e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs4595586 0.545 rs7967295 chr12:39376866 G/A cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs78545713 0.541 rs111465843 chr6:26222823 G/A cg23601095 chr6:26197514 HIST1H3D 0.67 5.68 0.3 2.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg07828340 chr4:882639 GAK 1.07 11.42 0.53 1.01e-25 Intelligence (multi-trait analysis); LUSC cis rs2011503 1.000 rs1036215 chr19:19657198 C/T cg11244672 chr19:19639970 YJEFN3 -0.63 -7.46 -0.38 7.66e-13 Bipolar disorder; LUSC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs79349575 0.783 rs9912829 chr17:46982749 G/C cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg15369054 chr17:80825471 TBCD -0.36 -5.91 -0.31 8.3e-9 Breast cancer; LUSC cis rs748404 0.723 rs11853991 chr15:43557549 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.96 0.4 2.72e-14 Lung cancer; LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg15790184 chr11:494944 RNH1 0.54 6.04 0.31 4.08e-9 Body mass index; LUSC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11890956 chr21:40555474 PSMG1 -0.85 -14.8 -0.63 1.9e-38 Cognitive function; LUSC cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 7.02 0.36 1.22e-11 Rheumatoid arthritis; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg03246824 chr11:118966313 H2AFX 0.46 5.96 0.31 6.42e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06634786 chr22:41940651 POLR3H -0.6 -7.1 -0.36 7.43e-12 Vitiligo; LUSC cis rs782590 0.902 rs782595 chr2:55845596 C/G cg03859395 chr2:55845619 SMEK2 0.88 16.62 0.67 1.23e-45 Metabolic syndrome; LUSC cis rs7428 0.924 rs12714140 chr2:85557591 A/T cg24342717 chr2:85555507 TGOLN2 -0.6 -8.66 -0.43 2.05e-16 Ear protrusion; LUSC trans rs198712 0.505 rs198312 chr7:24191306 A/C cg06529468 chr19:10676722 KRI1 0.38 6.11 0.32 2.83e-9 Aggressive periodontitis (sex interaction); LUSC cis rs57590327 0.508 rs9820349 chr3:81958587 A/G cg07356753 chr3:81810745 GBE1 -0.57 -8.04 -0.4 1.59e-14 Extraversion; LUSC cis rs1371867 0.875 rs1788187 chr8:101336099 A/G cg06636551 chr8:101224915 SPAG1 -0.38 -7.13 -0.36 6.31e-12 Atrioventricular conduction; LUSC cis rs79387448 0.745 rs1403549 chr2:103110745 G/C cg09003973 chr2:102972529 NA 0.87 8.56 0.42 4.21e-16 Gut microbiota (bacterial taxa); LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg27170947 chr2:26402098 FAM59B 0.72 11.04 0.52 2.26e-24 Gut microbiome composition (summer); LUSC cis rs62400317 0.859 rs12199256 chr6:45303493 T/G cg20913747 chr6:44695427 NA -0.47 -7.72 -0.39 1.35e-13 Total body bone mineral density; LUSC cis rs1559088 1.000 rs28840147 chr19:33561976 A/G cg17764715 chr19:33622953 WDR88 0.59 7.95 0.4 2.96e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20152424 chr11:576455 PHRF1;LOC143666 0.43 6.43 0.33 4.32e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72781680 0.821 rs72781644 chr2:24209348 T/C cg08917208 chr2:24149416 ATAD2B 0.6 6.9 0.35 2.66e-11 Lymphocyte counts; LUSC cis rs193541 0.626 rs4426910 chr5:122088838 A/T cg19077854 chr5:122220652 SNX24 0.28 6.26 0.32 1.18e-9 Glucose homeostasis traits; LUSC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg18404041 chr3:52824283 ITIH1 -0.52 -9.82 -0.47 3.77e-20 Bipolar disorder; LUSC cis rs1691799 0.899 rs1168328 chr12:66729250 T/C cg16791601 chr12:66731901 HELB -0.71 -12.44 -0.56 1.88e-29 White blood cell count (basophil); LUSC cis rs4654899 0.865 rs7541923 chr1:21403582 G/C cg01072550 chr1:21505969 NA -0.49 -7.15 -0.36 5.6e-12 Superior frontal gyrus grey matter volume; LUSC cis rs2580764 0.541 rs2968786 chr2:55264859 C/G cg09592903 chr2:55203963 RTN4 0.49 9.83 0.47 3.51e-20 Mean platelet volume; LUSC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg12311346 chr5:56204834 C5orf35 -0.92 -13.6 -0.6 7.64e-34 Initial pursuit acceleration; LUSC cis rs10791097 0.720 rs7119425 chr11:130733185 C/T cg12179176 chr11:130786555 SNX19 0.72 11.36 0.53 1.64e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg03885332 chr11:832357 CD151 -0.34 -5.84 -0.3 1.26e-8 Mean platelet volume; LUSC cis rs10979 1.000 rs9386033 chr6:143888520 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs4889855 0.614 rs9898443 chr17:78469357 C/T cg16591659 chr17:78472290 NA 0.48 8.15 0.41 7.21e-15 Fractional excretion of uric acid; LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg13047869 chr3:10149882 C3orf24 0.63 9.07 0.44 1.01e-17 Alzheimer's disease; LUSC cis rs9399135 0.967 rs12527683 chr6:135324534 C/T cg22676075 chr6:135203613 NA 0.49 7.62 0.39 2.56e-13 Red blood cell count; LUSC cis rs9486719 1.000 rs9400016 chr6:96940883 G/T cg06623918 chr6:96969491 KIAA0776 -0.82 -10.07 -0.48 5.09e-21 Migraine;Coronary artery disease; LUSC cis rs4648739 0.613 rs13303201 chr1:1903712 G/T cg14196676 chr1:1911069 KIAA1751 -0.6 -9.66 -0.47 1.27e-19 Severe influenza A (H1N1) infection; LUSC cis rs11252926 0.523 rs816596 chr10:548004 C/T cg03684893 chr10:554711 DIP2C -0.4 -7.21 -0.37 3.82e-12 Psychosis in Alzheimer's disease; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg04267008 chr7:1944627 MAD1L1 -0.5 -7.36 -0.37 1.42e-12 Bipolar disorder and schizophrenia; LUSC cis rs7119 0.651 rs12902449 chr15:77850926 A/G cg27398640 chr15:77910606 LINGO1 -0.33 -6.82 -0.35 4.32e-11 Type 2 diabetes; LUSC cis rs3849570 0.695 rs6792696 chr3:81874009 G/A cg07356753 chr3:81810745 GBE1 -0.59 -8.78 -0.43 8.46e-17 Waist circumference;Body mass index; LUSC cis rs9300255 0.602 rs10846486 chr12:123709927 G/A cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg18357645 chr12:58087776 OS9 0.44 6.11 0.32 2.74e-9 Multiple sclerosis; LUSC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg10523679 chr1:76189770 ACADM 0.85 11.3 0.53 2.74e-25 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs11098499 0.955 rs35916640 chr4:120155852 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC trans rs877282 0.898 rs11253347 chr10:765769 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.41 -0.33 4.97e-10 Uric acid levels; LUSC cis rs2346177 0.875 rs2166745 chr2:46646879 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.56 -8.77 -0.43 9.27e-17 HDL cholesterol; LUSC cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.7 -0.3 2.59e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg00149659 chr3:10157352 C3orf10 0.88 12.31 0.56 5.95e-29 Alzheimer's disease; LUSC cis rs9902453 0.765 rs8079209 chr17:28186773 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.15 0.52 9.34e-25 Coffee consumption (cups per day); LUSC cis rs8077577 0.895 rs62072464 chr17:18108314 T/C cg16794390 chr17:18148240 FLII 0.41 5.73 0.3 2.28e-8 Obesity-related traits; LUSC cis rs3806843 1.000 rs1548699 chr5:140164918 T/C cg26395211 chr5:140044315 WDR55 -0.39 -6.0 -0.31 5.16e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs11098499 0.954 rs12502423 chr4:120424172 A/C cg09307838 chr4:120376055 NA 0.78 11.68 0.54 1.15e-26 Corneal astigmatism; LUSC cis rs7759001 0.857 rs12195788 chr6:27356406 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs9902453 0.845 rs3102558 chr17:28023142 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.44 0.46 6.85e-19 Coffee consumption (cups per day); LUSC cis rs7106204 0.748 rs7101572 chr11:24213982 A/G ch.11.24196551F chr11:24239977 NA 1.12 12.64 0.57 3.29e-30 Response to Homoharringtonine (cytotoxicity); LUSC cis rs8062405 0.755 rs4788073 chr16:28594549 A/G cg07382826 chr16:28625726 SULT1A1 0.27 5.82 0.3 1.39e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs73198271 0.773 rs66618176 chr8:8646974 G/C cg15556689 chr8:8085844 FLJ10661 -0.47 -6.17 -0.32 2.02e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9747201 0.962 rs34016823 chr17:80095428 G/T cg18209359 chr17:80159595 CCDC57 0.39 6.5 0.34 2.94e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg13535736 chr9:111863775 C9orf5 -0.43 -7.1 -0.36 7.64e-12 Menarche (age at onset); LUSC cis rs1371867 0.846 rs1660347 chr8:101314980 G/A cg06636551 chr8:101224915 SPAG1 -0.45 -8.29 -0.41 2.89e-15 Atrioventricular conduction; LUSC cis rs2717559 0.568 rs35093407 chr8:143885501 G/A cg17252645 chr8:143867129 LY6D -0.32 -5.67 -0.3 3.11e-8 Urinary tract infection frequency; LUSC cis rs2479724 0.591 rs2243605 chr6:41828070 T/A cg17623882 chr6:41773611 USP49 -0.52 -6.79 -0.35 5.25e-11 Menarche (age at onset); LUSC cis rs870825 0.655 rs7675046 chr4:185652201 G/A cg04058563 chr4:185651563 MLF1IP -0.79 -11.92 -0.55 1.5e-27 Blood protein levels; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg19747945 chr6:42946146 PEX6 -0.34 -5.73 -0.3 2.27e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg03433033 chr1:76189801 ACADM 0.84 15.34 0.64 1.48e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs1878931 0.580 rs8062722 chr16:3409161 G/A cg22508957 chr16:3507546 NAT15 -0.35 -5.69 -0.3 2.82e-8 Body mass index (adult); LUSC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg17279839 chr7:150038598 RARRES2 0.43 6.58 0.34 1.81e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7005380 0.531 rs9649948 chr8:120913535 A/G cg21744203 chr8:120868354 DSCC1 -0.48 -5.79 -0.3 1.63e-8 Interstitial lung disease; LUSC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.46 6.95 0.36 1.94e-11 Platelet count; LUSC cis rs3093024 1.000 rs3093023 chr6:167534290 A/G cg07741184 chr6:167504864 NA -0.49 -8.7 -0.43 1.53e-16 Rheumatoid arthritis; LUSC cis rs965469 1.000 rs6037553 chr20:3313884 A/G cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.3 3.37e-8 IFN-related cytopenia; LUSC cis rs7806994 1 rs7806994 chr7:56139505 A/T cg21096502 chr7:56174374 CHCHD2 -0.58 -6.3 -0.33 9.24e-10 PR interval in Tripanosoma cruzi seropositivity; LUSC cis rs11122272 0.735 rs2250704 chr1:231486647 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.93 -0.48 1.53e-20 Hemoglobin concentration; LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 14.39 0.62 7.35e-37 Platelet count; LUSC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg20302533 chr7:39170763 POU6F2 0.57 9.48 0.46 4.86e-19 IgG glycosylation; LUSC trans rs11098499 0.954 rs9685777 chr4:120365965 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.27 0.32 1.14e-9 Corneal astigmatism; LUSC trans rs7939886 0.844 rs17150088 chr11:55894862 T/G cg15704280 chr7:45808275 SEPT13 0.81 6.78 0.35 5.49e-11 Myopia (pathological); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19783675 chr5:132362235 ZCCHC10 -0.5 -5.97 -0.31 6.1e-9 Bipolar disorder and schizophrenia; LUSC cis rs28830936 1.000 rs17677991 chr15:42032383 C/G cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.03 -0.31 4.33e-9 Diastolic blood pressure; LUSC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs877282 0.891 rs12357999 chr10:796468 A/C cg13042288 chr15:90349979 ANPEP -0.48 -6.99 -0.36 1.47e-11 Uric acid levels; LUSC cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg26395211 chr5:140044315 WDR55 -0.47 -7.39 -0.37 1.21e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg13047869 chr3:10149882 C3orf24 0.65 9.51 0.46 3.98e-19 Alzheimer's disease; LUSC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22590775 chr19:49891494 CCDC155 0.61 8.79 0.43 8.23e-17 Multiple sclerosis; LUSC cis rs6692729 1.000 rs6692729 chr1:227018919 C/T cg10327440 chr1:227177885 CDC42BPA 0.48 6.96 0.36 1.85e-11 Electrodermal activity; LUSC cis rs965469 1.000 rs6051736 chr20:3296898 T/C cg25506879 chr20:3388711 C20orf194 -0.52 -5.66 -0.3 3.18e-8 IFN-related cytopenia; LUSC cis rs637571 0.528 rs11602769 chr11:65594139 T/C cg17985854 chr11:65770987 BANF1;EIF1AD -0.42 -7.51 -0.38 5.46e-13 Eosinophil percentage of white cells; LUSC cis rs17597773 0.527 rs1537806 chr1:221084222 G/A cg16008148 chr1:221062819 NA 0.41 7.77 0.39 1e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11924390 0.800 rs5030059 chr3:186452455 C/G cg12454167 chr3:186435060 KNG1 0.29 7.45 0.38 7.85e-13 Adiponectin levels; LUSC cis rs7098414 0.531 rs3844126 chr10:82019997 T/G cg01528321 chr10:82214614 TSPAN14 0.61 9.41 0.46 8.6e-19 Post bronchodilator FEV1; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08638395 chr1:180601032 XPR1 0.51 7.25 0.37 2.85e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs137603 0.502 rs137627 chr22:39716341 G/A cg17798944 chr22:39715225 SNORD43;RPL3 -0.52 -8.28 -0.41 2.92e-15 Primary biliary cholangitis; LUSC cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg08564027 chr20:61660810 NA 0.92 17.17 0.68 8.42e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg20849893 chr7:64541193 NA 0.44 6.39 0.33 5.51e-10 Calcium levels; LUSC trans rs3733585 0.699 rs4588456 chr4:9963895 A/T cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 7.86 0.4 5.32e-14 Bipolar disorder; LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 10.3 0.49 8.64e-22 Alzheimer's disease; LUSC cis rs506338 0.517 rs490192 chr11:64471369 C/T cg19395706 chr11:64412079 NRXN2 0.29 5.93 0.31 7.43e-9 Body mass index;Urate levels; LUSC cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg16346588 chr10:242978 ZMYND11 -0.42 -6.03 -0.31 4.28e-9 Psychosis in Alzheimer's disease; LUSC cis rs4900538 0.821 rs7012 chr14:102814945 C/T cg18135206 chr14:102964638 TECPR2 -0.96 -18.12 -0.7 1.37e-51 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs394563 0.625 rs394526 chr6:149796975 T/G cg07828024 chr6:149772892 ZC3H12D -0.34 -6.99 -0.36 1.54e-11 Dupuytren's disease; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.01 0.31 4.83e-9 Lymphocyte counts; LUSC cis rs6690583 0.524 rs12045710 chr1:85451765 T/C cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.02e-10 Serum sulfate level; LUSC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg21984481 chr17:79567631 NPLOC4 0.68 14.27 0.62 2.03e-36 Eye color traits; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg10729496 chr3:10149963 C3orf24 0.52 6.93 0.35 2.21e-11 Alzheimer's disease; LUSC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.45 -0.38 7.92e-13 Aortic root size; LUSC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg14773178 chr5:1868261 NA 0.32 5.92 0.31 8.16e-9 Cardiovascular disease risk factors; LUSC cis rs9733 0.687 rs11204735 chr1:150841667 T/C cg13175981 chr1:150552382 MCL1 0.45 6.23 0.32 1.4e-9 Tonsillectomy; LUSC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg21285383 chr16:89894308 SPIRE2 0.33 7.03 0.36 1.19e-11 Vitiligo; LUSC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg24209194 chr3:40518798 ZNF619 0.48 6.41 0.33 4.93e-10 Renal cell carcinoma; LUSC cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg26395211 chr5:140044315 WDR55 0.46 7.33 0.37 1.72e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg05347473 chr6:146136440 FBXO30 0.51 8.61 0.43 2.96e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11890956 chr21:40555474 PSMG1 0.87 15.06 0.64 1.73e-39 Cognitive function; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16488304 chr1:151119217 SEMA6C 0.46 6.39 0.33 5.61e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg16414030 chr3:133502952 NA -0.51 -8.05 -0.4 1.45e-14 Iron status biomarkers; LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.95 0.7 6.41e-51 Chronic sinus infection; LUSC cis rs8077577 1.000 rs2015336 chr17:18073610 A/G cg16794390 chr17:18148240 FLII 0.43 6.12 0.32 2.63e-9 Obesity-related traits; LUSC trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg20587970 chr11:113659929 NA -1.36 -19.2 -0.72 6.89e-56 Hip circumference adjusted for BMI; LUSC cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg05347473 chr6:146136440 FBXO30 0.48 8.11 0.41 9.98e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs453301 0.624 rs7014430 chr8:8827737 T/G cg15556689 chr8:8085844 FLJ10661 0.57 8.98 0.44 2.08e-17 Joint mobility (Beighton score); LUSC cis rs3008870 0.920 rs1925413 chr1:67417101 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.12 0.64 1.04e-39 Lymphocyte percentage of white cells; LUSC cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg23711669 chr6:146136114 FBXO30 0.82 14.37 0.62 8.27e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg15423357 chr2:25149977 NA 0.45 9.03 0.44 1.37e-17 Body mass index; LUSC cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg13256891 chr4:100009986 ADH5 0.43 5.99 0.31 5.48e-9 Alcohol dependence; LUSC cis rs12579753 1.000 rs11613196 chr12:82173251 A/T cg21231944 chr12:82153410 PPFIA2 0.39 5.97 0.31 6.07e-9 Resting heart rate; LUSC cis rs11190604 1.000 rs3793771 chr10:102222957 C/G cg16342193 chr10:102329863 NA -0.36 -6.5 -0.34 2.87e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg01368799 chr11:117014884 PAFAH1B2 0.51 6.68 0.34 9.92e-11 Blood protein levels; LUSC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.56 0.5 1.07e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC cis rs12908161 1.000 rs35524990 chr15:85258203 T/C cg11189052 chr15:85197271 WDR73 0.49 5.98 0.31 5.78e-9 Schizophrenia; LUSC trans rs6854783 0.715 rs6812389 chr4:145626096 C/G cg07161172 chr15:71184870 LRRC49;THAP10 0.4 6.17 0.32 2.02e-9 Height; LUSC cis rs3771570 0.901 rs4675963 chr2:242324763 G/A cg21155796 chr2:242212141 HDLBP 0.51 6.25 0.32 1.28e-9 Prostate cancer; LUSC cis rs34375054 0.624 rs7295689 chr12:125680922 T/G cg25124228 chr12:125621409 AACS -0.4 -5.67 -0.3 3.09e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10489202 1.000 rs7520232 chr1:168011995 T/C cg24449463 chr1:168025552 DCAF6 -0.58 -7.32 -0.37 1.88e-12 Schizophrenia; LUSC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg17971929 chr21:40555470 PSMG1 -0.64 -10.52 -0.5 1.52e-22 Cognitive function; LUSC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs113835537 0.808 rs10896128 chr11:66324529 G/A cg24851651 chr11:66362959 CCS 0.47 5.82 0.3 1.37e-8 Airway imaging phenotypes; LUSC cis rs941873 0.805 rs876678 chr10:81111036 G/T cg11057378 chr10:81107060 PPIF 0.36 6.05 0.31 3.97e-9 Height; LUSC cis rs9302635 0.550 rs35959677 chr16:72200801 G/T cg01557791 chr16:72042693 DHODH -0.5 -6.44 -0.33 4.22e-10 Blood protein levels; LUSC cis rs12493885 0.585 rs787811 chr3:153622907 G/T cg17054900 chr3:154042577 DHX36 -0.59 -6.08 -0.32 3.33e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1506636 1.000 rs10225428 chr7:123357646 A/G cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -8.13 -0.41 8.56e-15 Lymphocyte counts; LUSC cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.75 0.51 2.45e-23 Bone mineral density; LUSC cis rs6574644 0.959 rs28622938 chr14:81772635 G/T cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs7589342 0.507 rs6543338 chr2:106403911 C/G cg14210321 chr2:106509881 NCK2 -0.41 -5.87 -0.31 1.06e-8 Addiction; LUSC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg21951975 chr1:209979733 IRF6 0.58 8.64 0.43 2.31e-16 Cleft lip with or without cleft palate; LUSC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg15445000 chr17:37608096 MED1 -0.4 -6.81 -0.35 4.56e-11 Glomerular filtration rate (creatinine); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22998610 chr11:62538411 TAF6L -0.39 -6.0 -0.31 5.17e-9 Hepatitis; LUSC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg09455208 chr3:40491958 NA 0.6 10.16 0.49 2.59e-21 Renal cell carcinoma; LUSC cis rs7572644 0.723 rs13023003 chr2:28032137 G/C cg27432699 chr2:27873401 GPN1 0.57 7.39 0.37 1.17e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2273669 0.510 rs78596296 chr6:109374465 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -5.83 -0.3 1.28e-8 Prostate cancer; LUSC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg04450456 chr4:17643702 FAM184B 0.39 6.57 0.34 1.9e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8114671 0.967 rs4911476 chr20:33780768 A/C cg24642439 chr20:33292090 TP53INP2 -0.4 -5.9 -0.31 9.15e-9 Height; LUSC cis rs9921338 0.961 rs72773825 chr16:11412448 A/G cg00044050 chr16:11439710 C16orf75 -0.5 -6.83 -0.35 3.91e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC trans rs6598955 0.572 rs12089219 chr1:26638751 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.0 -0.4 2.09e-14 Obesity-related traits; LUSC cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg08754478 chr10:133766260 PPP2R2D -0.63 -7.99 -0.4 2.27e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs7818345 1.000 rs6981898 chr8:19305705 A/G cg11303988 chr8:19266685 CSGALNACT1 0.34 6.47 0.33 3.39e-10 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1790761 0.806 rs1638557 chr11:67215988 C/G cg24690094 chr11:67383802 NA -0.31 -5.67 -0.3 3.12e-8 Mean corpuscular volume; LUSC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg12641515 chr19:46296257 DMWD 0.5 7.43 0.38 8.93e-13 Coronary artery disease; LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg02951883 chr7:2050386 MAD1L1 -0.58 -10.63 -0.5 6.39e-23 Bipolar disorder and schizophrenia; LUSC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg06212747 chr3:49208901 KLHDC8B 0.66 9.37 0.46 1.11e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs3754214 0.836 rs12023277 chr1:150466737 A/G cg15654264 chr1:150340011 RPRD2 0.45 7.24 0.37 3.13e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs3812049 0.737 rs1112956 chr5:127433798 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.63 -8.6 -0.43 3.06e-16 Lymphocyte counts;Red cell distribution width; LUSC cis rs6840360 0.638 rs2406974 chr4:152601841 G/A cg22705602 chr4:152727874 NA -0.33 -6.86 -0.35 3.4e-11 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.524 rs61895760 chr11:47794538 G/C cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs1153858 1.000 rs2453541 chr15:45645378 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.05 0.4 1.49e-14 Homoarginine levels; LUSC cis rs2486288 0.656 rs8039138 chr15:45551592 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.89 -0.4 4.34e-14 Glomerular filtration rate; LUSC cis rs7833986 0.501 rs2719261 chr8:56941982 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.72 11.91 0.55 1.64e-27 Height; LUSC cis rs10761482 0.500 rs10994411 chr10:62304808 C/A cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.55e-12 Schizophrenia; LUSC cis rs4654899 0.802 rs10493004 chr1:21442736 T/C cg02927042 chr1:21476669 EIF4G3 -0.37 -5.88 -0.31 9.98e-9 Superior frontal gyrus grey matter volume; LUSC cis rs394563 0.602 rs409099 chr6:149766863 T/G cg16235748 chr6:149772707 ZC3H12D -0.29 -5.95 -0.31 6.74e-9 Dupuytren's disease; LUSC cis rs28595532 0.702 rs56217716 chr4:119338490 T/G cg02775129 chr4:119771670 NA -0.76 -6.33 -0.33 7.79e-10 Cannabis dependence symptom count; LUSC cis rs2742234 0.910 rs2503866 chr10:43646261 T/A cg15436174 chr10:43711423 RASGEF1A -0.37 -6.76 -0.35 6.22e-11 Hirschsprung disease; LUSC trans rs9951602 0.512 rs6506872 chr18:76649695 T/C cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.39 0.42 1.37e-15 Prudent dietary pattern; LUSC cis rs2710642 0.962 rs7557501 chr2:63086639 C/T cg17519650 chr2:63277830 OTX1 0.48 6.8 0.35 4.96e-11 LDL cholesterol levels;LDL cholesterol; LUSC cis rs9815354 0.812 rs73081321 chr3:41890231 G/A cg03022575 chr3:42003672 ULK4 0.84 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1003719 0.591 rs1053966 chr21:38568009 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.52 -7.65 -0.39 2.18e-13 Eye color traits; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg07395648 chr5:131743802 NA 0.39 5.74 0.3 2.09e-8 Blood metabolite levels; LUSC cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg15839431 chr19:19639596 YJEFN3 0.57 6.26 0.32 1.18e-9 Bipolar disorder; LUSC cis rs4588572 0.643 rs10474555 chr5:77799193 A/G cg11547950 chr5:77652471 NA 0.57 8.63 0.43 2.62e-16 Triglycerides; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08385486 chr2:74874383 C2orf65 -0.7 -6.5 -0.34 2.94e-10 Cognitive performance; LUSC cis rs4631830 0.896 rs7088225 chr10:51522120 T/C cg16070123 chr10:51489643 NA 0.49 7.93 0.4 3.29e-14 Prostate-specific antigen levels; LUSC cis rs2798269 1.000 rs2761912 chr13:22134037 C/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.13 -0.32 2.42e-9 PR segment; LUSC cis rs11112613 0.609 rs6539218 chr12:105934875 C/T cg03607813 chr12:105948248 NA 0.64 8.19 0.41 5.68e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7106204 0.748 rs7947388 chr11:24224903 A/G ch.11.24196551F chr11:24239977 NA 1.13 14.81 0.63 1.67e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1568889 1.000 rs66702115 chr11:28181703 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 9.39 0.46 9.37e-19 Bipolar disorder; LUSC cis rs2050392 0.792 rs684395 chr10:30719112 C/G cg18806716 chr10:30721971 MAP3K8 -0.49 -7.99 -0.4 2.28e-14 Inflammatory bowel disease; LUSC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg20607287 chr7:12443886 VWDE -0.6 -6.2 -0.32 1.65e-9 Coronary artery disease; LUSC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg22655196 chr4:3374909 RGS12 0.31 5.97 0.31 5.9e-9 Serum sulfate level; LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.42 6.8 0.35 4.77e-11 Cognitive function; LUSC trans rs3785574 0.962 rs62077512 chr17:61851435 C/T cg09060275 chr22:27053596 MIAT -0.4 -6.03 -0.31 4.45e-9 Height; LUSC cis rs8141797 1.000 rs8138799 chr22:24556902 G/A cg00411358 chr22:24577142 SUSD2 -0.58 -6.05 -0.31 3.84e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs5753618 0.519 rs5997939 chr22:31677130 C/G cg22777020 chr22:31556080 RNF185 -0.47 -5.94 -0.31 7.04e-9 Colorectal cancer; LUSC cis rs67981189 0.593 rs2877708 chr14:71484126 C/G cg15816911 chr14:71606274 NA 0.32 5.73 0.3 2.26e-8 Schizophrenia; LUSC cis rs698813 0.763 rs1067335 chr2:44625958 T/C cg00619915 chr2:44497795 NA -0.42 -6.04 -0.31 4.06e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs6500395 0.962 rs989070 chr16:48602243 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.29 0.33 1e-9 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs34844492 0.744 rs17072704 chr3:65271885 C/T cg25341313 chr1:235069288 NA 0.59 6.01 0.31 4.92e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs13040088 1.000 rs2273412 chr20:61553802 G/A cg23096297 chr20:61557774 DIDO1 0.84 10.46 0.5 2.36e-22 Menopause (age at onset); LUSC cis rs7572644 0.679 rs9679543 chr2:28050951 C/T cg27432699 chr2:27873401 GPN1 0.52 7.14 0.36 5.69e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9311676 0.656 rs55913214 chr3:58388026 A/G cg13750441 chr3:58318267 PXK 0.35 6.72 0.35 7.86e-11 Systemic lupus erythematosus; LUSC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg06697600 chr4:7070879 GRPEL1 0.41 6.14 0.32 2.34e-9 Monocyte percentage of white cells; LUSC cis rs10782582 0.593 rs11802717 chr1:76124648 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.16 -0.36 5.33e-12 Daytime sleep phenotypes; LUSC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg05025164 chr4:1340916 KIAA1530 0.42 6.28 0.32 1.07e-9 Obesity-related traits; LUSC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg10295955 chr4:187884368 NA -1.07 -24.0 -0.8 1.07e-74 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg05347473 chr6:146136440 FBXO30 0.66 11.35 0.53 1.75e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg19622623 chr12:86230825 RASSF9 -0.45 -6.52 -0.34 2.59e-10 Major depressive disorder; LUSC cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg11644478 chr21:40555479 PSMG1 -0.57 -8.72 -0.43 1.31e-16 Menarche (age at onset); LUSC cis rs6429082 0.818 rs291386 chr1:235647050 C/T cg26050004 chr1:235667680 B3GALNT2 0.62 8.55 0.42 4.53e-16 Adiposity; LUSC cis rs346785 0.610 rs347674 chr17:74278548 C/G cg09812376 chr17:74270190 QRICH2 -0.38 -7.11 -0.36 7.27e-12 White matter hyperintensities in ischemic stroke; LUSC cis rs7772486 0.790 rs2254288 chr6:146204470 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.31 -0.37 1.95e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7647973 1.000 rs6446275 chr3:49466871 A/G cg07636037 chr3:49044803 WDR6 -0.69 -9.0 -0.44 1.76e-17 Menarche (age at onset); LUSC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.24e-21 Bipolar disorder; LUSC cis rs4423214 0.802 rs4402322 chr11:71184015 C/G cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg26513180 chr16:89883248 FANCA 0.79 6.38 0.33 5.97e-10 Skin colour saturation; LUSC cis rs4295623 0.559 rs2409836 chr8:11689228 T/G cg00262122 chr8:11665843 FDFT1 0.51 7.72 0.39 1.35e-13 Morning vs. evening chronotype; LUSC cis rs721399 0.553 rs59416053 chr8:18240800 G/C cg18736775 chr8:18248649 NAT2 -0.58 -6.88 -0.35 2.98e-11 Blood metabolite levels; LUSC cis rs2456568 0.548 rs7117597 chr11:93655091 A/G cg26875233 chr11:93583750 C11orf90 -0.3 -5.89 -0.31 9.44e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs11587682 0.578 rs12121421 chr1:150404666 A/G cg11822372 chr1:151115635 SEMA6C -0.47 -6.11 -0.32 2.73e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.44 6.17 0.32 2.03e-9 Osteoporosis; LUSC cis rs7568458 0.684 rs60012532 chr2:85752474 A/C cg23752985 chr2:85803571 VAMP8 0.3 5.79 0.3 1.62e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.95 0.4 2.83e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs931812 0.757 rs4734014 chr8:101908844 A/G cg20993868 chr7:22813445 NA 0.53 9.99 0.48 9.99e-21 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.89 -0.44 3.84e-17 Bipolar disorder; LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg26314531 chr2:26401878 FAM59B -0.69 -9.67 -0.47 1.13e-19 Gut microbiome composition (summer); LUSC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg14019146 chr3:50243930 SLC38A3 -0.32 -7.12 -0.36 6.49e-12 Intelligence (multi-trait analysis); LUSC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg00339695 chr16:24857497 SLC5A11 0.62 9.47 0.46 5.47e-19 Intelligence (multi-trait analysis); LUSC cis rs611744 0.647 rs2859813 chr8:109263497 G/A cg21045802 chr8:109455806 TTC35 0.43 6.63 0.34 1.38e-10 Dupuytren's disease; LUSC cis rs1358748 0.555 rs2815388 chr1:67538853 C/T cg02640540 chr1:67518911 SLC35D1 0.66 6.69 0.34 9.24e-11 Tuberculosis; LUSC cis rs73416724 1.000 rs1214762 chr6:43355151 C/T cg26312998 chr6:43337775 ZNF318 -0.52 -6.35 -0.33 6.93e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg13393036 chr8:95962371 TP53INP1 -0.46 -9.57 -0.46 2.49e-19 Type 2 diabetes; LUSC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg23205692 chr1:25664452 TMEM50A 0.44 6.65 0.34 1.19e-10 Erythrocyte sedimentation rate; LUSC cis rs9300255 0.569 rs1727320 chr12:123700476 T/A cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs7119 0.717 rs62009071 chr15:77817886 C/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.48 -0.33 3.3e-10 Type 2 diabetes; LUSC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg05623727 chr3:50126028 RBM5 -0.35 -6.66 -0.34 1.11e-10 Body mass index; LUSC cis rs1535500 1.000 rs3734618 chr6:39284184 A/G cg06347083 chr6:39282316 KCNK17 -0.27 -5.98 -0.31 5.68e-9 Type 2 diabetes; LUSC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg25036284 chr2:26402008 FAM59B -0.68 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC cis rs3859192 0.599 rs34933056 chr17:38162983 G/A cg17467752 chr17:38218738 THRA -0.49 -6.87 -0.35 3.12e-11 White blood cell count; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg12143784 chr7:64541923 NA -0.44 -6.89 -0.35 2.81e-11 Calcium levels; LUSC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg22875332 chr1:76189707 ACADM -0.79 -12.39 -0.56 2.84e-29 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2274459 0.841 rs12661400 chr6:33696477 C/T cg06253072 chr6:33679850 C6orf125 0.5 6.0 0.31 5.28e-9 Obesity (extreme); LUSC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg11861562 chr11:117069780 TAGLN 0.45 8.16 0.41 6.97e-15 Blood protein levels; LUSC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg07716408 chr11:68623521 NA -0.34 -6.76 -0.35 6.28e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg01475377 chr6:109611718 NA 0.46 8.4 0.42 1.28e-15 Reticulocyte fraction of red cells; LUSC cis rs7122539 0.646 rs682842 chr11:66568943 A/G cg18002602 chr11:66138449 SLC29A2 0.33 5.99 0.31 5.37e-9 HIV-1 susceptibility; LUSC cis rs6537837 0.762 rs6691984 chr1:110144024 G/T cg05049280 chr1:110155535 GNAT2 0.43 6.21 0.32 1.53e-9 Major depressive disorder; LUSC cis rs9902453 0.904 rs12939344 chr17:28328819 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.38 -0.49 4.5e-22 Coffee consumption (cups per day); LUSC cis rs62380364 0.557 rs663046 chr5:88036486 C/T cg22951263 chr5:87985283 NA -0.45 -7.25 -0.37 2.85e-12 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.863 rs13140409 chr4:120503460 A/G cg09307838 chr4:120376055 NA 0.74 10.7 0.51 3.6e-23 Corneal astigmatism; LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg00166722 chr3:10149974 C3orf24 0.57 7.65 0.39 2.14e-13 Alzheimer's disease; LUSC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.48 -0.33 3.25e-10 Menopause (age at onset); LUSC cis rs7178375 0.607 rs7171212 chr15:31207711 C/T cg03767031 chr15:31195708 MTMR15 0.79 6.41 0.33 4.95e-10 Hypertriglyceridemia; LUSC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg11062466 chr8:58055876 NA 0.67 7.65 0.39 2.2e-13 Developmental language disorder (linguistic errors); LUSC cis rs7615316 0.779 rs6769786 chr3:142097777 A/G cg16271453 chr3:142027066 XRN1 -0.41 -7.18 -0.37 4.48e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg08472276 chr7:1133186 C7orf50;GPER -0.35 -5.84 -0.3 1.21e-8 Longevity;Endometriosis; LUSC cis rs3125734 0.633 rs6479792 chr10:63983264 T/G cg09941381 chr10:64027924 RTKN2 -0.37 -6.94 -0.36 2.03e-11 Rheumatoid arthritis; LUSC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg26597838 chr10:835615 NA 0.85 11.75 0.54 6.37e-27 Eosinophil percentage of granulocytes; LUSC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg08493051 chr2:3487164 NA -0.56 -8.81 -0.43 6.76e-17 Neurofibrillary tangles; LUSC cis rs9469578 1.000 rs73743336 chr6:33715391 G/A cg18708504 chr6:33715942 IP6K3 0.72 8.8 0.43 7.52e-17 Phosphorus levels; LUSC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.27 -0.45 2.34e-18 Gut microbiome composition (summer); LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg22638593 chr5:131593259 PDLIM4 0.44 6.48 0.33 3.29e-10 Acylcarnitine levels; LUSC cis rs6582630 0.593 rs7134006 chr12:38596245 A/C cg26384229 chr12:38710491 ALG10B 0.86 14.35 0.62 1.04e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs9549367 0.601 rs558869 chr13:113849932 G/T cg18105134 chr13:113819100 PROZ 0.65 9.62 0.47 1.67e-19 Platelet distribution width; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg11905131 chr22:24372483 LOC391322 -0.51 -8.78 -0.43 8.92e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9314323 0.557 rs3779916 chr8:26250906 C/A cg13160058 chr8:26243215 BNIP3L -0.33 -6.05 -0.31 3.8e-9 Red cell distribution width; LUSC cis rs12190007 0.517 rs3006210 chr6:169828915 C/T cg15038512 chr6:170123185 PHF10 -0.39 -6.31 -0.33 9.05e-10 Obesity-related traits; LUSC cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg16230307 chr14:35515116 FAM177A1 0.79 10.05 0.48 6.13e-21 Psoriasis; LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg05368731 chr17:41323189 NBR1 0.92 15.84 0.66 1.49e-42 Menopause (age at onset); LUSC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg08048268 chr3:133502702 NA -0.41 -8.06 -0.4 1.42e-14 Iron status biomarkers; LUSC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg14004847 chr7:1930337 MAD1L1 -0.51 -7.96 -0.4 2.7e-14 Bipolar disorder and schizophrenia; LUSC cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg24642439 chr20:33292090 TP53INP2 0.52 7.91 0.4 3.72e-14 Coronary artery disease; LUSC cis rs736408 0.500 rs2878762 chr3:52919002 T/C cg11645453 chr3:52864694 ITIH4 0.48 10.32 0.49 7.62e-22 Bipolar disorder; LUSC cis rs1595825 0.735 rs2164327 chr2:198726773 C/T cg00982548 chr2:198649783 BOLL -0.58 -7.24 -0.37 3.14e-12 Ulcerative colitis; LUSC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg11764359 chr7:65958608 NA 0.62 9.11 0.45 7.59e-18 Aortic root size; LUSC cis rs34779708 0.931 rs1926556 chr10:35344907 T/C cg04310649 chr10:35416472 CREM -0.4 -6.13 -0.32 2.5e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11098499 0.738 rs34566984 chr4:120361270 G/A cg09307838 chr4:120376055 NA 0.77 11.16 0.52 8.86e-25 Corneal astigmatism; LUSC cis rs1403694 0.695 rs3806689 chr3:186435077 A/G cg12454167 chr3:186435060 KNG1 0.34 8.47 0.42 8.11e-16 Blood protein levels; LUSC cis rs1577917 0.958 rs34230196 chr6:86526022 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg22307029 chr19:49891270 CCDC155 0.62 7.87 0.4 5.04e-14 Multiple sclerosis; LUSC cis rs11997175 0.935 rs6990082 chr8:33708034 C/A ch.8.33884649F chr8:33765107 NA 0.42 6.49 0.33 3.18e-10 Body mass index; LUSC trans rs7637701 0.713 rs9818780 chr3:156492758 T/C cg11006288 chr14:69012387 RAD51L1 0.39 6.23 0.32 1.41e-9 Breast cancer; LUSC cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg00631329 chr6:26305371 NA -0.45 -8.9 -0.44 3.69e-17 Educational attainment; LUSC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg15448220 chr1:150897856 SETDB1 0.38 5.66 0.3 3.19e-8 Tonsillectomy; LUSC cis rs1009647 0.677 rs11851870 chr14:55815982 A/C cg04306507 chr14:55594613 LGALS3 0.46 6.37 0.33 6.15e-10 Testicular germ cell tumor; LUSC cis rs10892173 0.545 rs115865940 chr11:117666711 C/T cg21640587 chr11:117668038 DSCAML1 0.7 10.53 0.5 1.42e-22 Myopia; LUSC cis rs12291225 0.883 rs1864658 chr11:14256444 C/T cg19336497 chr11:14380999 RRAS2 0.44 8.17 0.41 6.23e-15 Sense of smell; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01056350 chr1:210502156 HHAT -0.41 -6.06 -0.31 3.77e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg00684032 chr4:1343700 KIAA1530 0.43 7.73 0.39 1.25e-13 Obesity-related traits; LUSC cis rs4253772 0.530 rs9615989 chr22:46803774 A/T cg24881330 chr22:46731750 TRMU 0.78 5.75 0.3 2.02e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg07716408 chr11:68623521 NA -0.31 -6.24 -0.32 1.33e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg19920283 chr7:105172520 RINT1 0.58 6.11 0.32 2.71e-9 Bipolar disorder (body mass index interaction); LUSC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg03804128 chr16:635623 NA 0.3 5.86 0.31 1.13e-8 Height; LUSC cis rs6066835 1.000 rs6066835 chr20:47355009 A/G cg18078177 chr20:47281410 PREX1 0.71 6.7 0.34 8.84e-11 Multiple myeloma; LUSC cis rs7192380 0.965 rs7187634 chr16:69663371 T/C cg26679644 chr16:69762563 NA 0.35 6.15 0.32 2.17e-9 Sjögren's syndrome; LUSC cis rs1790761 0.554 rs12787511 chr11:67401635 G/C cg24690094 chr11:67383802 NA -0.45 -8.09 -0.4 1.11e-14 Mean corpuscular volume; LUSC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -8.53 -0.42 5.29e-16 Personality dimensions; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.54 0.76 3.92e-65 Prudent dietary pattern; LUSC cis rs12318506 0.793 rs71460129 chr12:75699427 C/T cg04728562 chr12:75699417 CAPS2 -0.82 -6.03 -0.31 4.29e-9 Coronary artery calcification; LUSC cis rs1595825 0.735 rs113834557 chr2:198611624 A/G cg19156104 chr2:198669113 PLCL1 -0.47 -5.66 -0.3 3.26e-8 Ulcerative colitis; LUSC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg06740227 chr12:86229804 RASSF9 0.44 7.15 0.36 5.5e-12 Major depressive disorder; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg11494091 chr17:61959527 GH2 0.65 13.92 0.61 4.91e-35 Prudent dietary pattern; LUSC cis rs2996428 0.667 rs113120570 chr1:3770450 G/C cg13057898 chr1:3703894 LRRC47 0.49 8.66 0.43 2.02e-16 Red cell distribution width; LUSC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg15557168 chr22:42548783 NA 0.46 7.39 0.37 1.18e-12 Schizophrenia; LUSC cis rs2439831 1.000 rs689754 chr15:43775895 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.43 0.42 1.04e-15 Lung cancer in ever smokers; LUSC cis rs34524635 1 rs34524635 chr10:65261176 CT/C cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.07e-10 Vascular endothelial growth factor levels; LUSC cis rs9527 0.567 rs11191573 chr10:104896816 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg26513180 chr16:89883248 FANCA 0.92 17.98 0.7 5.01e-51 Vitiligo; LUSC cis rs672059 0.806 rs3754524 chr1:183153267 C/T ch.1.3577855R chr1:183094577 LAMC1 0.52 7.76 0.39 1.03e-13 Hypertriglyceridemia; LUSC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg17340268 chr14:105411764 AHNAK2 -0.38 -6.06 -0.31 3.75e-9 Rheumatoid arthritis; LUSC cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg23711669 chr6:146136114 FBXO30 0.73 12.77 0.57 1.14e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs7953249 0.807 rs2393791 chr12:121423956 A/G cg02403541 chr12:121454288 C12orf43 0.6 8.8 0.43 7.22e-17 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC trans rs12310956 0.532 rs10844715 chr12:33968444 A/G cg26384229 chr12:38710491 ALG10B 0.67 10.48 0.5 2.08e-22 Morning vs. evening chronotype; LUSC trans rs8072100 0.701 rs6503807 chr17:45772932 T/C cg03886242 chr7:26192032 NFE2L3 -0.4 -6.08 -0.32 3.29e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.23 -0.37 3.33e-12 Menarche (age at onset); LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg27588902 chr6:42928151 GNMT -0.29 -6.46 -0.33 3.78e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs10979 1.000 rs9399448 chr6:143896315 G/T cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs11864453 0.826 rs2074626 chr16:72139184 C/A cg01557791 chr16:72042693 DHODH -0.51 -7.36 -0.37 1.48e-12 Fibrinogen levels; LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg14092988 chr3:52407081 DNAH1 -0.31 -6.06 -0.31 3.61e-9 Bipolar disorder; LUSC cis rs9469578 1.000 rs73743328 chr6:33713550 G/A cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17106222 chr13:33590343 KL 0.44 6.45 0.33 3.97e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs34375054 0.624 rs12826658 chr12:125680237 A/G cg25124228 chr12:125621409 AACS -0.4 -5.7 -0.3 2.65e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6977660 0.714 rs9969381 chr7:19827454 C/T cg05791153 chr7:19748676 TWISTNB 0.65 6.55 0.34 2.17e-10 Thyroid stimulating hormone; LUSC trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg03929089 chr4:120376271 NA -0.6 -7.21 -0.37 3.79e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs1577917 0.917 rs1579886 chr6:86557191 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs6960043 0.875 rs17168594 chr7:15048776 T/C cg19272540 chr7:15055459 NA -0.31 -7.31 -0.37 1.93e-12 Type 2 diabetes; LUSC cis rs12464483 0.524 rs1901906 chr2:30884576 A/G cg07150166 chr2:30669952 LCLAT1 -0.53 -6.26 -0.32 1.16e-9 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs9788682 0.747 rs2656072 chr15:78744292 A/G cg06917634 chr15:78832804 PSMA4 0.48 6.02 0.31 4.61e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11155671 0.530 rs9397398 chr6:150193603 G/A cg13206674 chr6:150067644 NUP43 0.44 6.7 0.34 8.89e-11 Testicular germ cell tumor; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg14092988 chr3:52407081 DNAH1 0.32 6.15 0.32 2.19e-9 Bipolar disorder; LUSC trans rs2243480 1.000 rs160634 chr7:65528664 C/T cg10756647 chr7:56101905 PSPH -0.78 -7.82 -0.39 6.82e-14 Diabetic kidney disease; LUSC cis rs7772486 0.875 rs2328712 chr6:146344563 T/C cg23711669 chr6:146136114 FBXO30 0.84 15.05 0.64 1.97e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg14092988 chr3:52407081 DNAH1 0.31 5.94 0.31 7.06e-9 Bipolar disorder; LUSC cis rs11785693 0.862 rs11780705 chr8:4988221 G/A cg26367366 chr8:4980734 NA 0.83 9.78 0.47 4.92e-20 Neuroticism (multi-trait analysis);Neuroticism; LUSC trans rs208520 0.526 rs9294682 chr6:66795159 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.23 -25.77 -0.82 2.2e-81 Exhaled nitric oxide output; LUSC trans rs911555 0.755 rs4906329 chr14:103942669 A/G cg17675199 chr6:35436792 RPL10A -0.43 -6.25 -0.32 1.29e-9 Intelligence (multi-trait analysis); LUSC cis rs7202877 0.706 rs37602 chr16:75505046 C/T cg04384234 chr16:75411784 CFDP1 0.63 8.99 0.44 1.87e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7945705 0.791 rs4579928 chr11:8815704 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.48 9.49 0.46 4.6e-19 Hemoglobin concentration; LUSC cis rs7582720 0.943 rs72934734 chr2:203739970 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg00012203 chr2:219082015 ARPC2 -0.57 -9.06 -0.44 1.11e-17 Ulcerative colitis; LUSC cis rs9467773 0.844 rs2393669 chr6:26503873 C/T cg09904177 chr6:26538194 HMGN4 0.73 13.27 0.59 1.45e-32 Intelligence (multi-trait analysis); LUSC trans rs941408 0.515 rs1640262 chr19:2779134 C/T cg19676328 chr12:49525230 TUBA1B 0.51 7.34 0.37 1.6e-12 Total cholesterol levels; LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg16479474 chr6:28041457 NA 0.34 5.89 0.31 9.45e-9 Parkinson's disease; LUSC cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg09904177 chr6:26538194 HMGN4 0.69 11.95 0.55 1.22e-27 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2832191 0.716 rs9983051 chr21:30371890 C/T cg14791747 chr16:20752902 THUMPD1 -0.42 -6.41 -0.33 4.97e-10 Dental caries; LUSC cis rs11250097 0.507 rs2409779 chr8:11311340 A/T cg21775007 chr8:11205619 TDH -0.57 -7.64 -0.39 2.33e-13 Neuroticism; LUSC cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg03060546 chr3:49711283 APEH 0.56 7.77 0.39 1.01e-13 Resting heart rate; LUSC cis rs2286885 1.000 rs10760439 chr9:129250830 A/C cg15282417 chr9:129245246 FAM125B 0.4 6.61 0.34 1.54e-10 Intraocular pressure; LUSC cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg23262351 chr6:79576851 IRAK1BP1 -0.37 -5.7 -0.3 2.63e-8 Intelligence (multi-trait analysis); LUSC cis rs6460942 0.630 rs17670901 chr7:12386622 G/A cg06484146 chr7:12443880 VWDE -0.58 -6.14 -0.32 2.38e-9 Coronary artery disease; LUSC cis rs950027 0.572 rs12910764 chr15:45609360 T/C cg14582100 chr15:45693742 SPATA5L1 -0.45 -8.37 -0.42 1.55e-15 Response to fenofibrate (adiponectin levels); LUSC cis rs3770081 1.000 rs12614260 chr2:86303079 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.08 -6.95 -0.36 1.88e-11 Facial emotion recognition (sad faces); LUSC cis rs3741151 0.773 rs73542990 chr11:73134398 C/T cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9911578 0.842 rs12450766 chr17:56832965 G/C cg05425664 chr17:57184151 TRIM37 0.57 8.04 0.4 1.57e-14 Intelligence (multi-trait analysis); LUSC cis rs17095355 1.000 rs11194924 chr10:111695773 G/C cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.96 -0.36 1.81e-11 Biliary atresia; LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg27535305 chr1:53392650 SCP2 -0.37 -6.83 -0.35 3.99e-11 Monocyte count; LUSC cis rs5769707 0.681 rs4622843 chr22:50036916 T/G cg07959070 chr22:50026188 C22orf34 -0.33 -6.23 -0.32 1.4e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.52 -0.59 1.59e-33 Chronic sinus infection; LUSC cis rs9399135 0.838 rs4896126 chr6:135342786 C/A cg22676075 chr6:135203613 NA 0.47 7.37 0.37 1.32e-12 Red blood cell count; LUSC cis rs3820928 0.874 rs11685983 chr2:227799853 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.65 -0.39 2.11e-13 Pulmonary function; LUSC cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg11266682 chr4:10021025 SLC2A9 -0.53 -9.82 -0.47 3.71e-20 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs714027 1.000 rs757024 chr22:30471679 G/C cg11564601 chr22:30592435 NA -0.37 -6.89 -0.35 2.76e-11 Lymphocyte counts; LUSC cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.29e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs6982636 1.000 rs2954019 chr8:126477759 G/A cg13325919 chr3:181432053 SOX2;SOX2OT -0.35 -6.68 -0.34 1e-10 Lipid metabolism phenotypes; LUSC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg22433210 chr17:43662623 NA -0.72 -10.45 -0.5 2.62e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2832077 0.943 rs11702320 chr21:30195251 A/T cg24692254 chr21:30365293 RNF160 -0.58 -7.22 -0.37 3.57e-12 Cognitive test performance; LUSC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg14895029 chr7:2775587 GNA12 -0.37 -6.06 -0.31 3.77e-9 Height; LUSC cis rs4363385 0.617 rs5010885 chr1:152973141 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.88 -0.4 4.72e-14 Inflammatory skin disease; LUSC cis rs354225 0.544 rs1137645 chr2:54807592 C/G cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs3820928 0.874 rs10439363 chr2:227815065 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.91 -0.4 3.79e-14 Pulmonary function; LUSC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg04414720 chr1:150670196 GOLPH3L 0.53 8.47 0.42 8.01e-16 Melanoma; LUSC cis rs1153858 1.000 rs2668747 chr15:45617216 T/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.06 0.48 5.61e-21 Homoarginine levels; LUSC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.63 0.6 6.32e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg08499158 chr17:42289980 UBTF 0.51 8.55 0.42 4.61e-16 Total body bone mineral density; LUSC cis rs12893668 0.703 rs4906338 chr14:104050357 A/G cg08213375 chr14:104286397 PPP1R13B 0.34 5.68 0.3 2.87e-8 Reticulocyte count; LUSC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.86 0.4 5.38e-14 Bipolar disorder; LUSC cis rs11997175 0.583 rs66622174 chr8:33812542 T/G ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.17e-10 Body mass index; LUSC cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg18132916 chr6:79620363 NA -0.37 -5.73 -0.3 2.28e-8 Intelligence (multi-trait analysis); LUSC cis rs17604090 0.775 rs76480599 chr7:29689180 A/G cg19413766 chr7:29689036 LOC646762 -0.54 -6.71 -0.34 8.45e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg04369109 chr6:150039330 LATS1 -0.59 -8.63 -0.43 2.52e-16 Lung cancer; LUSC cis rs2573652 1.000 rs2573625 chr15:100513158 A/G cg09918751 chr15:100517450 ADAMTS17 0.37 6.79 0.35 5.16e-11 Height; LUSC cis rs72781680 1.000 rs115861480 chr2:24129464 T/A cg20701182 chr2:24300061 SF3B14 0.75 7.63 0.39 2.55e-13 Lymphocyte counts; LUSC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg12257692 chr3:49977190 RBM6 -0.26 -7.41 -0.38 1.02e-12 Body mass index; LUSC cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg12310025 chr6:25882481 NA -0.35 -5.78 -0.3 1.74e-8 Height; LUSC cis rs4499344 0.531 rs259247 chr19:33147657 T/C cg22980127 chr19:33182716 NUDT19 -0.43 -6.24 -0.32 1.34e-9 Mean platelet volume; LUSC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg09365446 chr1:150670422 GOLPH3L 0.52 7.47 0.38 6.89e-13 Melanoma; LUSC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg09324608 chr17:30823087 MYO1D 0.34 5.77 0.3 1.83e-8 Schizophrenia; LUSC trans rs7618501 0.633 rs12496973 chr3:50002245 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.07 0.44 1.02e-17 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg05368731 chr17:41323189 NBR1 0.84 14.22 0.61 3.22e-36 Menopause (age at onset); LUSC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg20307385 chr11:47447363 PSMC3 0.44 5.8 0.3 1.58e-8 Subjective well-being; LUSC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 13.62 0.6 6.8e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs748404 0.631 rs7166812 chr15:43644760 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.32 0.33 8.32e-10 Lung cancer; LUSC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg17179660 chr6:151773299 C6orf211;RMND1 -0.46 -6.73 -0.35 7.2e-11 Menarche (age at onset); LUSC cis rs4654899 0.865 rs72988025 chr1:21351441 A/G cg01072550 chr1:21505969 NA -0.51 -7.52 -0.38 5.13e-13 Superior frontal gyrus grey matter volume; LUSC trans rs6952808 0.692 rs56727870 chr7:2029940 T/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.41 0.33 4.9e-10 Bipolar disorder and schizophrenia; LUSC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg19774624 chr17:42201019 HDAC5 -0.8 -13.17 -0.58 3.49e-32 Total body bone mineral density; LUSC cis rs6580649 1.000 rs7305954 chr12:48403530 C/T cg24011408 chr12:48396354 COL2A1 0.54 7.57 0.38 3.76e-13 Lung cancer; LUSC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg14829155 chr15:31115871 NA -0.69 -10.23 -0.49 1.56e-21 Huntington's disease progression; LUSC cis rs7312933 0.533 rs17551006 chr12:42848738 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.96 0.36 1.77e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg02549819 chr16:58548995 SETD6 0.96 9.16 0.45 5.54e-18 Schizophrenia; LUSC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.25 0.37 3e-12 Platelet count; LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs12681288 0.676 rs6983981 chr8:1016011 A/C cg04851639 chr8:1020857 NA -0.39 -7.98 -0.4 2.3e-14 Schizophrenia; LUSC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg12963246 chr6:28129442 ZNF389 0.52 7.5 0.38 5.81e-13 Parkinson's disease; LUSC trans rs9650657 0.665 rs7002117 chr8:10616169 A/G cg15556689 chr8:8085844 FLJ10661 0.43 6.29 0.33 9.75e-10 Neuroticism; LUSC cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.77e-30 Motion sickness; LUSC cis rs7777754 1.000 rs7777754 chr7:50666033 A/C cg18232548 chr7:50535776 DDC -0.47 -6.35 -0.33 6.93e-10 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg00750074 chr16:89608354 SPG7 -0.44 -7.56 -0.38 3.99e-13 Multiple myeloma (IgH translocation); LUSC cis rs7719624 0.870 rs58759191 chr5:135395827 C/G cg12897067 chr5:135418308 NA 0.4 5.77 0.3 1.79e-8 Response to cytidine analogues (gemcitabine); LUSC cis rs1577917 0.655 rs1059307 chr6:86387888 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 7.03 0.36 1.17e-11 Response to antipsychotic treatment; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -10.28 -0.49 9.82e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs354225 0.626 rs7608414 chr2:54844995 G/A cg01766943 chr2:54829624 SPTBN1 0.47 7.55 0.38 4.28e-13 Schizophrenia; LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg27535305 chr1:53392650 SCP2 -0.35 -6.59 -0.34 1.68e-10 Monocyte count; LUSC cis rs1559088 0.847 rs8110181 chr19:33605939 G/A cg27124370 chr19:33622961 WDR88 0.57 7.37 0.37 1.37e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs73200209 0.662 rs17426872 chr12:116636915 T/C cg01776926 chr12:116560359 MED13L -0.48 -5.98 -0.31 5.75e-9 Total body bone mineral density; LUSC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs7291412 0.929 rs7289457 chr22:46456603 C/T cg24349631 chr22:46449752 C22orf26;LOC150381 0.38 6.25 0.32 1.23e-9 Dupuytren's disease;Subjective well-being; LUSC cis rs2073300 0.609 rs77673953 chr20:23398794 G/C cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9527 0.590 rs12775302 chr10:104911356 A/G cg05855489 chr10:104503620 C10orf26 0.52 7.98 0.4 2.38e-14 Arsenic metabolism; LUSC cis rs9486715 0.838 rs7770889 chr6:96858453 C/T cg06623918 chr6:96969491 KIAA0776 -0.9 -16.82 -0.68 2.1e-46 Headache; LUSC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg14784868 chr12:69753453 YEATS4 0.81 13.83 0.6 1.03e-34 Blood protein levels; LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.68 0.3 2.88e-8 Menopause (age at onset); LUSC cis rs11583043 1.000 rs34915449 chr1:101476786 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 6.01 0.31 4.96e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg05347473 chr6:146136440 FBXO30 0.47 7.68 0.39 1.75e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg19468946 chr17:37922297 IKZF3 -0.43 -6.85 -0.35 3.54e-11 Self-reported allergy; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.48 6.49 0.33 3.16e-10 Renal function-related traits (BUN); LUSC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs9905704 0.624 rs34718875 chr17:57072461 G/A cg12560992 chr17:57184187 TRIM37 0.64 10.49 0.5 1.97e-22 Testicular germ cell tumor; LUSC trans rs9860340 0.730 rs57368400 chr3:87639755 G/A cg03644585 chr7:884825 UNC84A 0.42 6.03 0.31 4.35e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.8 0.47 4.11e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2607426 0.681 rs2254338 chr19:41255603 G/A cg05508168 chr19:41255947 C19orf54;SNRPA 0.84 5.85 0.3 1.18e-8 Blood protein levels; LUSC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.98 0.36 1.57e-11 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.931 rs11010130 chr10:35513307 T/C cg04310649 chr10:35416472 CREM -0.41 -6.34 -0.33 7.54e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.4e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs897984 0.806 rs10782002 chr16:30946506 A/G cg02466173 chr16:30829666 NA 0.56 10.92 0.51 6.12e-24 Dementia with Lewy bodies; LUSC cis rs2938670 1 rs2938670 chr15:78740688 T/G cg18825076 chr15:78729989 IREB2 -0.6 -9.81 -0.47 3.86e-20 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1 in COPD;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6840360 0.550 rs6836343 chr4:152497564 A/G cg22705602 chr4:152727874 NA -0.34 -6.82 -0.35 4.21e-11 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.78 -12.61 -0.57 4.54e-30 Chronic sinus infection; LUSC cis rs1957429 0.901 rs1467569 chr14:65347986 T/C cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg08470875 chr2:26401718 FAM59B -0.68 -9.08 -0.45 9.33e-18 Gut microbiome composition (summer); LUSC cis rs6754459 1.000 rs6754459 chr2:3707423 C/T cg25251562 chr2:3704773 ALLC -0.43 -7.26 -0.37 2.74e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.15 -0.36 5.54e-12 Colorectal cancer; LUSC cis rs950169 0.922 rs12915832 chr15:85111457 C/T cg17173187 chr15:85201210 NMB 0.35 6.37 0.33 6.25e-10 Schizophrenia; LUSC cis rs7953508 0.659 rs1316739 chr12:93968256 G/A cg18151635 chr12:93972918 NA -0.63 -9.63 -0.47 1.5700000000000001e-19 Pubertal anthropometrics; LUSC cis rs7917772 0.510 rs2001389 chr10:104375258 G/A cg22532475 chr10:104410764 TRIM8 -0.25 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs45509595 0.841 rs9368531 chr6:27781872 G/C cg01620082 chr3:125678407 NA -0.69 -7.05 -0.36 1.06e-11 Breast cancer; LUSC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs10465746 0.725 rs4907185 chr1:84336047 T/C cg10977910 chr1:84465055 TTLL7 0.53 7.57 0.38 3.76e-13 Obesity-related traits; LUSC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2820315 0.867 rs2820317 chr1:201878537 G/C cg10061532 chr1:201886748 LMOD1 0.28 6.44 0.33 4.04e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13732083 chr21:47605072 C21orf56 -0.43 -6.48 -0.33 3.39e-10 Testicular germ cell tumor; LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg00080972 chr5:178986291 RUFY1 -0.64 -12.35 -0.56 3.95e-29 Lung cancer; LUSC cis rs9611565 0.500 rs2011053 chr22:42121278 G/A cg17376030 chr22:41985996 PMM1 -0.42 -5.7 -0.3 2.6e-8 Vitiligo; LUSC cis rs9300255 0.739 rs10846491 chr12:123753492 C/G cg00376283 chr12:123451042 ABCB9 0.68 8.46 0.42 8.47e-16 Neutrophil percentage of white cells; LUSC cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.82 -0.35 4.33e-11 Monocyte percentage of white cells; LUSC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg19539972 chr4:7069911 GRPEL1 0.6 7.0 0.36 1.44e-11 Monocyte percentage of white cells; LUSC cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9815354 1.000 rs6768542 chr3:41865474 G/A cg03022575 chr3:42003672 ULK4 0.59 6.55 0.34 2.2e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs11690935 0.959 rs4668412 chr2:172619770 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.52 -0.62 2.36e-37 Schizophrenia; LUSC cis rs6840360 0.571 rs11726892 chr4:152555106 A/G cg22705602 chr4:152727874 NA -0.31 -6.17 -0.32 1.98e-9 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.45 7.38 0.37 1.23e-12 Vitiligo; LUSC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg21918786 chr6:109611834 NA 0.42 7.31 0.37 1.97e-12 Reticulocyte fraction of red cells; LUSC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg13393036 chr8:95962371 TP53INP1 -0.46 -9.64 -0.47 1.5e-19 Type 2 diabetes; LUSC cis rs909002 0.830 rs10914460 chr1:32113216 T/C cg01639898 chr1:32083012 HCRTR1 0.32 7.83 0.39 6.71e-14 Intelligence (multi-trait analysis); LUSC trans rs35110281 1.000 rs35110281 chr21:45068947 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 12.06 0.55 4.65e-28 Mean corpuscular volume; LUSC cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg23158103 chr7:148848205 ZNF398 -0.5 -8.06 -0.4 1.38e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs9650657 0.615 rs11986935 chr8:10691549 T/A cg27411982 chr8:10470053 RP1L1 -0.38 -6.18 -0.32 1.85e-9 Neuroticism; LUSC cis rs7674212 0.507 rs223317 chr4:103802824 T/C cg16532752 chr4:104119610 CENPE -0.41 -5.67 -0.3 3.14e-8 Type 2 diabetes; LUSC cis rs12760731 0.565 rs12732507 chr1:178098296 A/G cg00404053 chr1:178313656 RASAL2 0.68 6.9 0.35 2.55e-11 Obesity-related traits; LUSC cis rs6906287 0.647 rs10456917 chr6:118779419 A/C cg21191810 chr6:118973309 C6orf204 0.33 6.0 0.31 5.17e-9 Electrocardiographic conduction measures; LUSC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg06640241 chr16:89574553 SPG7 0.92 17.08 0.68 1.88e-47 Multiple myeloma (IgH translocation); LUSC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg00990874 chr7:1149470 C7orf50 -0.61 -8.15 -0.41 7.3e-15 Bronchopulmonary dysplasia; LUSC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -6.1 -0.32 2.9e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9302635 0.513 rs7198572 chr16:72183220 G/A cg01557791 chr16:72042693 DHODH -0.51 -6.59 -0.34 1.74e-10 Blood protein levels; LUSC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.18 -0.41 6.04e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4356932 1.000 rs4456983 chr4:76958688 A/G cg00809888 chr4:76862425 NAAA 0.34 5.75 0.3 1.98e-8 Blood protein levels; LUSC cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg00049323 chr5:472564 LOC25845 0.5 7.94 0.4 3.13e-14 Cystic fibrosis severity; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.0 -23.08 -0.78 3.95e-71 Prudent dietary pattern; LUSC cis rs57590327 0.503 rs898763 chr3:81513408 T/C cg07356753 chr3:81810745 GBE1 0.46 6.1 0.32 3.01e-9 Extraversion; LUSC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 16.98 0.68 4.78e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12711979 0.509 rs10200764 chr2:3827772 C/G cg17052675 chr2:3827356 NA -0.84 -20.23 -0.74 5.51e-60 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs1534166 0.647 rs13321680 chr3:133507119 G/T cg01448562 chr3:133502909 NA 0.59 9.15 0.45 5.78e-18 Alcohol consumption (transferrin glycosylation); LUSC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg02711726 chr17:80685570 FN3KRP -0.42 -6.43 -0.33 4.31e-10 Glycated hemoglobin levels; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg27535305 chr1:53392650 SCP2 -0.49 -9.66 -0.47 1.22e-19 Monocyte count; LUSC cis rs3136441 1.000 rs2306028 chr11:46900659 G/T cg01183595 chr11:46746236 F2 0.38 5.67 0.3 3.12e-8 HDL cholesterol; LUSC cis rs6430585 0.528 rs309172 chr2:136674028 A/G cg07169764 chr2:136633963 MCM6 1.12 18.11 0.7 1.48e-51 Corneal structure; LUSC cis rs4654899 0.865 rs1472831 chr1:21435940 C/T cg01072550 chr1:21505969 NA -0.5 -7.4 -0.38 1.13e-12 Superior frontal gyrus grey matter volume; LUSC cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg11645453 chr3:52864694 ITIH4 0.3 7.06 0.36 9.72e-12 Electroencephalogram traits; LUSC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg26818010 chr10:134567672 INPP5A -0.82 -10.72 -0.51 2.99e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2688608 0.647 rs2633319 chr10:75691247 A/T cg17411546 chr10:75410026 SYNPO2L -0.39 -5.7 -0.3 2.7e-8 Inflammatory bowel disease; LUSC trans rs4689592 0.554 rs3951346 chr4:7073321 C/T cg07817883 chr1:32538562 TMEM39B -0.58 -7.23 -0.37 3.26e-12 Monocyte percentage of white cells; LUSC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 13.88 0.6 6.44e-35 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg22532475 chr10:104410764 TRIM8 0.35 7.95 0.4 2.82e-14 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg11766577 chr21:47581405 C21orf56 0.41 5.84 0.3 1.25e-8 Testicular germ cell tumor; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11468462 chr12:57610686 NXPH4 -0.53 -6.28 -0.32 1.04e-9 Bipolar disorder and schizophrenia; LUSC cis rs425277 0.958 rs626479 chr1:2110260 A/G cg24578937 chr1:2090814 PRKCZ -0.59 -13.83 -0.6 1.04e-34 Height; LUSC cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg27129171 chr3:47204927 SETD2 0.69 11.58 0.54 2.66e-26 Colorectal cancer; LUSC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.15 0.32 2.17e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12586317 0.620 rs79832710 chr14:35547434 G/T cg05294307 chr14:35346193 BAZ1A -0.58 -6.75 -0.35 6.68e-11 Psoriasis; LUSC cis rs3736594 0.513 rs62138966 chr2:27819172 G/A cg27432699 chr2:27873401 GPN1 0.65 8.63 0.43 2.6e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg21132104 chr15:45694354 SPATA5L1 -0.57 -8.22 -0.41 4.67e-15 Homoarginine levels; LUSC cis rs1008375 0.800 rs35463363 chr4:17613423 G/T cg16339924 chr4:17578868 LAP3 0.61 9.08 0.44 9.76e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7760535 0.757 rs10456875 chr6:111749725 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.73 -0.35 7.4e-11 Metabolic traits; LUSC cis rs4746818 0.892 rs2394505 chr10:70871598 A/G cg11621586 chr10:70884670 VPS26A -0.97 -11.31 -0.53 2.54e-25 Left atrial antero-posterior diameter; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22517552 chr7:30518520 NOD1 -0.51 -6.06 -0.31 3.62e-9 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg13010199 chr12:38710504 ALG10B 0.66 9.93 0.48 1.57e-20 Bladder cancer; LUSC cis rs11711311 1.000 rs2305545 chr3:113499733 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.81 -0.3 1.48e-8 IgG glycosylation; LUSC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg00310523 chr12:86230176 RASSF9 0.43 7.95 0.4 2.96e-14 Major depressive disorder; LUSC cis rs4594175 0.926 rs9323207 chr14:51621908 A/G cg23942311 chr14:51606299 NA -0.32 -6.02 -0.31 4.71e-9 Cancer; LUSC cis rs4888262 0.545 rs4588013 chr16:74703388 C/T cg05580060 chr16:74700937 RFWD3 0.41 5.68 0.3 2.88e-8 Testicular germ cell tumor; LUSC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg05234568 chr11:5960015 NA -0.62 -8.81 -0.43 7.2e-17 DNA methylation (variation); LUSC cis rs7605827 0.897 rs10166702 chr2:15528454 T/C cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.59e-17 Educational attainment (years of education); LUSC cis rs9611519 0.964 rs2179744 chr22:41621714 G/A cg03806693 chr22:41940476 POLR3H -0.46 -6.39 -0.33 5.62e-10 Neuroticism; LUSC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg22920501 chr2:26401640 FAM59B -0.73 -10.59 -0.5 8.37e-23 Gut microbiome composition (summer); LUSC cis rs7561273 0.609 rs10197527 chr2:24352398 A/C cg20701182 chr2:24300061 SF3B14 0.46 5.98 0.31 5.75e-9 Quantitative traits; LUSC cis rs17685 0.725 rs1044483 chr7:75659815 T/C cg16489192 chr7:75678113 MDH2;STYXL1 0.52 7.93 0.4 3.28e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10751667 0.666 rs7103585 chr11:971166 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.19e-10 Alzheimer's disease (late onset); LUSC cis rs965469 1.000 rs6051827 chr20:3372007 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -5.76 -0.3 1.9e-8 IFN-related cytopenia; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3803170 0.513 rs10774622 chr12:111833348 C/T cg10833066 chr12:111807467 FAM109A 0.38 7.19 0.37 4.31e-12 Mean corpuscular hemoglobin; LUSC cis rs7772486 0.875 rs2492855 chr6:146296926 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.79 0.43 7.96e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.78 0.43 8.69e-17 Axial length; LUSC cis rs72781680 1.000 rs72796326 chr2:24137047 G/A cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.4 -0.42 1.28e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs911119 0.866 rs6048920 chr20:23576844 A/G cg16589663 chr20:23618590 CST3 0.57 6.79 0.35 5.14e-11 Chronic kidney disease; LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg22963979 chr7:1858916 MAD1L1 -0.65 -10.71 -0.51 3.4e-23 Bipolar disorder and schizophrenia; LUSC cis rs7851660 0.809 rs12004762 chr9:100652755 A/G cg13688889 chr9:100608707 NA -0.53 -8.06 -0.4 1.36e-14 Strep throat; LUSC cis rs7223966 1.000 rs9909992 chr17:61731931 G/A cg05941027 chr17:61774174 LIMD2 0.21 5.68 0.3 2.95e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs8017423 0.935 rs10147186 chr14:90779879 G/C cg14092571 chr14:90743983 NA -0.36 -5.94 -0.31 7.24e-9 Mortality in heart failure; LUSC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg14552801 chr7:65878734 NA 0.37 5.86 0.31 1.12e-8 Aortic root size; LUSC cis rs7829975 0.626 rs332040 chr8:8730488 G/A cg11608241 chr8:8085544 FLJ10661 0.4 5.72 0.3 2.35e-8 Mood instability; LUSC cis rs9811920 0.809 rs793476 chr3:99541747 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -7.25 -0.37 2.94e-12 Axial length; LUSC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg00944433 chr1:107599041 PRMT6 0.38 7.0 0.36 1.4e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg06740227 chr12:86229804 RASSF9 0.46 7.49 0.38 6.14e-13 Major depressive disorder; LUSC cis rs30380 0.632 rs149189 chr5:96137804 A/G cg16492584 chr5:96139282 ERAP1 -0.57 -7.71 -0.39 1.5e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg10909506 chr17:38081995 ORMDL3 0.35 6.22 0.32 1.45e-9 Self-reported allergy; LUSC cis rs9457247 0.602 rs13204839 chr6:167471119 G/A cg07741184 chr6:167504864 NA 0.49 8.55 0.42 4.6e-16 Crohn's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19518383 chr11:64577818 MEN1 0.43 6.45 0.33 3.87e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs55871839 0.684 rs4738729 chr8:59808617 T/C cg07426533 chr8:59803705 TOX -0.37 -6.01 -0.31 4.76e-9 Pneumonia; LUSC cis rs9646944 0.501 rs11687768 chr2:103025738 A/G cg20060108 chr2:102954350 IL1RL1 0.5 6.99 0.36 1.54e-11 Blood protein levels; LUSC trans rs61931739 0.534 rs2625897 chr12:34064295 G/A cg13010199 chr12:38710504 ALG10B 0.54 8.3 0.41 2.53e-15 Morning vs. evening chronotype; LUSC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg07716408 chr11:68623521 NA -0.33 -6.32 -0.33 8.44e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1107366 1.000 rs9873704 chr3:125901902 G/C cg01346077 chr3:125931526 NA 0.36 6.98 0.36 1.63e-11 Metabolite levels; LUSC cis rs1348850 0.915 rs10930798 chr2:178446141 G/A cg22681709 chr2:178499509 PDE11A -0.47 -8.53 -0.42 5.28e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9611519 0.929 rs9611465 chr22:41426139 G/A cg03806693 chr22:41940476 POLR3H -0.51 -6.96 -0.36 1.86e-11 Neuroticism; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg18876405 chr7:65276391 NA 0.53 8.33 0.41 2.15e-15 Calcium levels; LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.92 0.61 4.72e-35 Alzheimer's disease; LUSC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg18876405 chr7:65276391 NA 0.58 9.57 0.46 2.55e-19 Aortic root size; LUSC cis rs9815354 0.812 rs17283677 chr3:41926148 C/T cg03022575 chr3:42003672 ULK4 -0.76 -8.16 -0.41 7.1e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs12971120 0.891 rs12605820 chr18:72167802 G/A cg26446133 chr18:72167187 CNDP2 -0.81 -9.95 -0.48 1.35e-20 Refractive error; LUSC cis rs28551159 1 rs28551159 chr6:26376368 A/G cg09904177 chr6:26538194 HMGN4 -0.74 -6.97 -0.36 1.7e-11 Urinary tract infection frequency; LUSC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs7107174 1.000 rs2512537 chr11:77971947 T/C cg02023728 chr11:77925099 USP35 0.52 7.2 0.37 4.11e-12 Testicular germ cell tumor; LUSC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg03354898 chr7:1950403 MAD1L1 -0.38 -7.18 -0.37 4.42e-12 Schizophrenia; LUSC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg05425664 chr17:57184151 TRIM37 -0.55 -8.11 -0.41 9.42e-15 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.692 rs6122349 chr20:61664096 T/C cg23505145 chr19:12996616 KLF1 0.52 7.28 0.37 2.41e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs477692 0.905 rs514963 chr10:131419707 C/T cg05714579 chr10:131428358 MGMT 0.51 7.8 0.39 8.26e-14 Response to temozolomide; LUSC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg06640241 chr16:89574553 SPG7 0.41 6.02 0.31 4.58e-9 Hemoglobin concentration; LUSC cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg19628046 chr18:33552617 C18orf21 0.48 5.8 0.3 1.56e-8 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs950169 0.881 rs34591918 chr15:84950833 C/T cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg08677398 chr8:58056175 NA 0.52 6.34 0.33 7.28e-10 Developmental language disorder (linguistic errors); LUSC cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.74 -0.51 2.58e-23 Alzheimer's disease (late onset); LUSC trans rs79976124 0.837 rs75346757 chr6:66648386 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 9.0 0.44 1.77e-17 Type 2 diabetes; LUSC cis rs5769707 0.605 rs6009791 chr22:50025265 T/C cg20744362 chr22:50050164 C22orf34 0.39 7.35 0.37 1.54e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg11645453 chr3:52864694 ITIH4 0.33 7.81 0.39 7.22e-14 Bipolar disorder; LUSC cis rs6693567 0.565 rs698917 chr1:150319884 G/A cg15654264 chr1:150340011 RPRD2 0.46 7.36 0.37 1.46e-12 Migraine; LUSC cis rs28647808 0.881 rs7852803 chr9:136245903 A/G cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.98 -0.31 5.67e-9 Blood protein levels; LUSC cis rs1559088 0.948 rs12610266 chr19:33581237 C/G cg17764715 chr19:33622953 WDR88 -0.61 -8.43 -0.42 1.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg19318889 chr4:1322082 MAEA 0.51 8.79 0.43 8.32e-17 Obesity-related traits; LUSC cis rs1979679 0.573 rs6487693 chr12:28727091 T/G cg13890972 chr12:28721907 NA -0.4 -5.86 -0.31 1.09e-8 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs7267979 0.714 rs1555329 chr20:25231858 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.66 12.14 0.55 2.38e-28 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1670533 1.000 rs11735663 chr4:1051845 C/T cg27284194 chr4:1044797 NA 0.57 8.45 0.42 8.91e-16 Recombination rate (females); LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg11965913 chr1:205819406 PM20D1 0.94 19.33 0.73 2.12e-56 Menarche (age at onset); LUSC cis rs34779708 0.966 rs12769484 chr10:35465746 G/A cg03585969 chr10:35415529 CREM 0.63 9.24 0.45 2.97e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs847577 0.609 rs6977321 chr7:97774859 A/G cg21770322 chr7:97807741 LMTK2 0.56 10.12 0.48 3.51e-21 Breast cancer; LUSC cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -6.98 -0.36 1.64e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7843479 0.965 rs4636204 chr8:21823206 T/G cg17168535 chr8:21777572 XPO7 0.66 10.09 0.48 4.62e-21 Mean corpuscular volume; LUSC cis rs5769765 0.908 rs4058453 chr22:50250297 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.62 6.57 0.34 1.96e-10 Schizophrenia; LUSC cis rs9902453 0.935 rs7220151 chr17:28334710 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.79 -0.43 8.23e-17 Coffee consumption (cups per day); LUSC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg22143856 chr6:28129313 ZNF389 0.41 5.97 0.31 6.03e-9 Parkinson's disease; LUSC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC cis rs11122272 0.701 rs2883799 chr1:231531166 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.25 -0.49 1.28e-21 Hemoglobin concentration; LUSC cis rs981844 0.816 rs62325148 chr4:154727993 A/G cg14289246 chr4:154710475 SFRP2 0.48 6.3 0.33 9.33e-10 Response to statins (LDL cholesterol change); LUSC cis rs2233152 0.572 rs10411008 chr19:41297241 T/C cg21869046 chr19:41225005 ITPKC 0.44 6.53 0.34 2.4e-10 Kawasaki disease; LUSC trans rs72674100 0.867 rs28673828 chr4:97991632 T/C cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg22782873 chr19:19639568 YJEFN3 -0.53 -6.17 -0.32 1.99e-9 Bipolar disorder; LUSC cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -11.11 -0.52 1.25e-24 Chronic sinus infection; LUSC cis rs7241530 0.662 rs56261404 chr18:75905961 G/A cg14642773 chr18:75888474 NA 0.39 5.99 0.31 5.45e-9 Educational attainment (years of education); LUSC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs1348850 0.574 rs12988366 chr2:178417945 A/C cg27490568 chr2:178487706 NA -0.42 -5.92 -0.31 7.98e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7215564 0.908 rs7501659 chr17:78662061 C/T cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs17270561 0.609 rs7746609 chr6:25727996 C/T cg17691542 chr6:26056736 HIST1H1C -0.51 -7.27 -0.37 2.59e-12 Iron status biomarkers; LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 13.2 0.59 2.71e-32 Alzheimer's disease; LUSC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg16049864 chr8:95962084 TP53INP1 -0.49 -7.86 -0.4 5.36e-14 Type 2 diabetes; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 2.93e-34 Prudent dietary pattern; LUSC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs7582720 1.000 rs72934510 chr2:203925360 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg23262073 chr20:60523788 NA 0.61 8.61 0.43 2.99e-16 Obesity-related traits; LUSC cis rs858239 0.601 rs6461693 chr7:23160133 A/G cg23682824 chr7:23144976 KLHL7 -0.41 -5.98 -0.31 5.87e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg08219700 chr8:58056026 NA 0.72 8.29 0.41 2.9e-15 Developmental language disorder (linguistic errors); LUSC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs7666738 0.546 rs10018080 chr4:98758436 C/A cg05340658 chr4:99064831 C4orf37 0.6 8.9 0.44 3.64e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.72 -0.72 5.79e-54 Height; LUSC cis rs9359856 0.510 rs2748298 chr6:90436877 A/C cg13799429 chr6:90582589 CASP8AP2 -0.93 -11.18 -0.52 7.07e-25 Bipolar disorder; LUSC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg23758822 chr17:41437982 NA 1.04 19.29 0.73 2.97e-56 Menopause (age at onset); LUSC cis rs2298450 0.593 rs2835326 chr21:37615731 C/G cg02919814 chr21:37666008 DOPEY2 -0.41 -6.13 -0.32 2.42e-9 Schizophrenia; LUSC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg15664640 chr17:80829946 TBCD 0.62 9.93 0.48 1.51e-20 Breast cancer; LUSC cis rs6686643 0.762 rs9333432 chr1:165611159 A/G cg16553119 chr1:165599451 MGST3 -0.46 -6.48 -0.33 3.32e-10 Total ventricular volume; LUSC cis rs4720118 0.875 rs3779239 chr7:33430271 G/A cg22798885 chr7:33102694 NT5C3 -0.47 -6.56 -0.34 2.07e-10 Leprosy; LUSC cis rs62400317 0.859 rs10456548 chr6:45219699 T/C cg20913747 chr6:44695427 NA -0.48 -7.62 -0.38 2.66e-13 Total body bone mineral density; LUSC cis rs716595 1.000 rs17127170 chr10:111992222 T/C cg13996003 chr10:112034540 MXI1 -0.7 -5.79 -0.3 1.63e-8 Normalized brain volume; LUSC cis rs6942756 1.000 rs1473236 chr7:128880831 G/T cg02491457 chr7:128862824 NA -0.53 -7.6 -0.38 3.09e-13 White matter hyperintensity burden; LUSC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.87 -0.35 3.2e-11 Lung cancer; LUSC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg01448562 chr3:133502909 NA -0.67 -10.98 -0.51 3.83e-24 Iron status biomarkers; LUSC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 5.65 0.3 3.46e-8 Electroencephalogram traits; LUSC cis rs35306767 0.633 rs17221491 chr10:1065191 A/G cg26597838 chr10:835615 NA 0.71 8.68 0.43 1.72e-16 Eosinophil percentage of granulocytes; LUSC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC trans rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05039488 chr6:79577232 IRAK1BP1 0.65 10.34 0.49 6.1e-22 Endometrial cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19857457 chr18:47018947 RPL17;SNORD58A;SNORD58B 0.44 7.78 0.39 9.12e-14 Triglycerides; LUSC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg05340658 chr4:99064831 C4orf37 0.65 10.99 0.52 3.31e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.873 rs6037062 chr20:25202892 G/A cg08601574 chr20:25228251 PYGB 0.47 7.38 0.37 1.27e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg01483505 chr11:975446 AP2A2 0.41 5.79 0.3 1.67e-8 Alzheimer's disease (late onset); LUSC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs6894249 0.874 rs11745587 chr5:131796922 A/G cg21138405 chr5:131827807 IRF1 -0.33 -6.0 -0.31 5.11e-9 Asthma; LUSC cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg06784218 chr1:46089804 CCDC17 -0.56 -11.73 -0.54 7.97e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.62e-12 Motion sickness; LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.49 6.06 0.31 3.77e-9 Renal function-related traits (BUN); LUSC cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.4 -0.42 1.3e-15 Schizophrenia; LUSC trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs427941 0.632 rs201509 chr7:101765002 C/T cg06246474 chr7:101738831 CUX1 0.39 6.4 0.33 5.38e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.64 0.67 1.09e-45 Gut microbiome composition (summer); LUSC cis rs2979489 0.945 rs11992441 chr8:30313649 A/G cg26383811 chr8:30366931 RBPMS 0.5 8.08 0.4 1.2e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs10875746 0.903 rs12306451 chr12:48483241 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg21361702 chr7:150065534 REPIN1 0.5 6.81 0.35 4.65e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg03605463 chr16:89740564 NA -0.57 -8.94 -0.44 2.77e-17 Vitiligo; LUSC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg24829409 chr8:58192753 C8orf71 -0.56 -6.02 -0.31 4.5e-9 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg04025307 chr7:1156635 C7orf50 0.46 7.05 0.36 1.05e-11 Longevity;Endometriosis; LUSC cis rs2742417 0.603 rs6807438 chr3:45778623 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.39 -0.37 1.22e-12 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs4295623 0.553 rs34962960 chr8:11594597 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -8.43 -0.42 1.02e-15 Morning vs. evening chronotype; LUSC cis rs11190604 1.000 rs2295773 chr10:102265815 A/G cg16342193 chr10:102329863 NA -0.35 -6.2 -0.32 1.65e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12971120 0.838 rs3794950 chr18:72182965 G/A cg26446133 chr18:72167187 CNDP2 -0.78 -8.8 -0.43 7.49e-17 Refractive error; LUSC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg04369109 chr6:150039330 LATS1 -0.56 -8.21 -0.41 4.77e-15 Lung cancer; LUSC cis rs10465746 0.809 rs2389617 chr1:84437652 A/T cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.02e-9 Obesity-related traits; LUSC cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.38 -6.24 -0.32 1.31e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7772486 0.875 rs2207785 chr6:146332784 T/G cg23711669 chr6:146136114 FBXO30 0.84 15.31 0.64 1.92e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs7000551 0.715 rs1530874 chr8:22347777 G/C cg12081754 chr8:22256438 SLC39A14 0.45 6.95 0.36 1.89e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg23630131 chr7:65973040 NA 0.2 5.66 0.3 3.25e-8 Aortic root size; LUSC cis rs7084921 0.608 rs12779818 chr10:101866118 G/A cg02250046 chr10:101825185 CPN1 -0.34 -6.28 -0.33 1.03e-9 Bone mineral density; LUSC cis rs1790761 0.967 rs1638556 chr11:67213518 A/G cg24690094 chr11:67383802 NA -0.31 -5.71 -0.3 2.46e-8 Mean corpuscular volume; LUSC cis rs11690935 0.959 rs10803863 chr2:172535337 T/C cg13550731 chr2:172543902 DYNC1I2 0.89 14.74 0.63 3.23e-38 Schizophrenia; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg19318889 chr4:1322082 MAEA 0.43 6.99 0.36 1.47e-11 Obesity-related traits; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg00129232 chr17:37814104 STARD3 -0.47 -7.0 -0.36 1.39e-11 Asthma; LUSC cis rs6940638 0.688 rs9295730 chr6:27128806 T/C cg12292205 chr6:26970375 C6orf41 -0.4 -5.9 -0.31 8.77e-9 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12368055 chr3:15469185 METTL6;EAF1 -0.41 -6.17 -0.32 1.96e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.47 7.42 0.38 9.95e-13 Menarche (age at onset); LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg02951883 chr7:2050386 MAD1L1 -0.39 -6.76 -0.35 6.26e-11 Bipolar disorder and schizophrenia; LUSC cis rs35146811 0.735 rs858512 chr7:99824453 A/G cg13334819 chr7:99746414 C7orf59 0.49 6.5 0.34 2.96e-10 Coronary artery disease; LUSC cis rs9398803 0.965 rs6919397 chr6:126659043 A/C cg19875578 chr6:126661172 C6orf173 0.37 5.66 0.3 3.22e-8 Male-pattern baldness; LUSC cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg07828340 chr4:882639 GAK 1.09 10.99 0.52 3.44e-24 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg18765753 chr7:1198926 ZFAND2A -0.48 -8.37 -0.42 1.59e-15 Longevity;Endometriosis; LUSC cis rs1348850 0.958 rs10930800 chr2:178459669 T/C cg22681709 chr2:178499509 PDE11A -0.48 -8.48 -0.42 7.37e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg10802521 chr3:52805072 NEK4 -0.53 -8.62 -0.43 2.69e-16 Bipolar disorder; LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs11250098 0.548 rs7837038 chr8:10783074 G/A cg27411982 chr8:10470053 RP1L1 -0.45 -6.74 -0.35 6.91e-11 Morning vs. evening chronotype; LUSC cis rs6005807 0.719 rs9625522 chr22:29045212 C/A cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2970818 0.764 rs11063161 chr12:4569117 C/T cg11146114 chr12:4671731 NA -0.62 -5.87 -0.31 1.03e-8 Phosphorus levels; LUSC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg02269571 chr22:50332266 NA 0.5 7.45 0.38 8.12e-13 Schizophrenia; LUSC cis rs11640533 1.000 rs11640533 chr16:53412862 A/G cg10144400 chr16:53407678 NA -0.41 -6.19 -0.32 1.77e-9 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.77 -0.35 5.69e-11 Bipolar disorder and schizophrenia; LUSC cis rs7903847 0.642 rs7092499 chr10:99140313 A/G cg20016023 chr10:99160130 RRP12 -0.3 -7.47 -0.38 7.17e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs2115536 0.692 rs8036559 chr15:80170563 C/T cg00225070 chr15:80189496 MTHFS 0.42 6.15 0.32 2.27e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.48e-24 Aortic root size; LUSC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.03 0.31 4.42e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg23719950 chr11:63933701 MACROD1 -0.62 -8.12 -0.41 9.04e-15 Mean platelet volume; LUSC cis rs977987 0.843 rs12927562 chr16:75482860 G/A cg03315344 chr16:75512273 CHST6 0.49 9.36 0.46 1.17e-18 Dupuytren's disease; LUSC cis rs9300255 0.568 rs1621194 chr12:123651018 T/C cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.15 -0.32 2.26e-9 Neutrophil percentage of white cells; LUSC cis rs17270561 0.553 rs9379784 chr6:25725506 A/G cg16482183 chr6:26056742 HIST1H1C 0.66 9.13 0.45 6.79e-18 Iron status biomarkers; LUSC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg18230493 chr5:56204884 C5orf35 0.58 9.14 0.45 6.19e-18 Coronary artery disease; LUSC cis rs8099014 0.861 rs4940706 chr18:56121803 C/T cg12907477 chr18:56117327 MIR122 -0.5 -7.11 -0.36 7.15e-12 Platelet count; LUSC cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg00898013 chr13:113819073 PROZ -0.52 -7.74 -0.39 1.19e-13 Platelet distribution width; LUSC cis rs10484885 0.793 rs1465954 chr6:90475013 G/A cg13799429 chr6:90582589 CASP8AP2 0.92 11.07 0.52 1.86e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs2286885 1.000 rs741025 chr9:129251792 C/T cg15282417 chr9:129245246 FAM125B 0.39 6.72 0.35 7.65e-11 Intraocular pressure; LUSC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg09165964 chr15:75287851 SCAMP5 0.46 6.83 0.35 4.14e-11 Breast cancer; LUSC cis rs6163 0.588 rs3818708 chr10:104503584 C/T cg05855489 chr10:104503620 C10orf26 0.92 18.54 0.71 3.01e-53 Waist circumference;Hip circumference; LUSC cis rs72634258 0.519 rs744001 chr1:7934557 G/A cg00042356 chr1:8021962 PARK7 0.63 7.17 0.37 4.86e-12 Inflammatory bowel disease; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg10982358 chr1:51435615 CDKN2C 0.44 6.53 0.34 2.49e-10 Schizophrenia; LUSC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg21782813 chr7:2030301 MAD1L1 0.52 9.13 0.45 6.63e-18 Bipolar disorder and schizophrenia; LUSC cis rs55728055 0.661 rs62239172 chr22:32047941 G/A cg01338084 chr22:32026380 PISD 0.94 6.72 0.35 7.7e-11 Age-related hearing impairment; LUSC cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg14689365 chr7:158441557 NCAPG2 -0.46 -6.19 -0.32 1.76e-9 Height; LUSC cis rs9807989 0.839 rs10206753 chr2:102968362 T/C cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg09365446 chr1:150670422 GOLPH3L -0.43 -6.45 -0.33 3.93e-10 Tonsillectomy; LUSC cis rs7818345 0.967 rs4546679 chr8:19283335 C/A cg11303988 chr8:19266685 CSGALNACT1 0.39 7.48 0.38 6.81e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6456156 0.586 rs4710176 chr6:167491639 T/C cg07741184 chr6:167504864 NA 0.45 7.62 0.38 2.64e-13 Primary biliary cholangitis; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg05896524 chr21:47604654 C21orf56 -0.49 -7.54 -0.38 4.44e-13 Testicular germ cell tumor; LUSC trans rs6982636 1.000 rs2980868 chr8:126488235 C/T cg13325919 chr3:181432053 SOX2;SOX2OT -0.33 -6.32 -0.33 8.36e-10 Lipid metabolism phenotypes; LUSC cis rs752010 0.714 rs6658500 chr1:42088344 A/G cg06885757 chr1:42089581 HIVEP3 -0.46 -9.52 -0.46 3.6e-19 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg07636037 chr3:49044803 WDR6 1.02 17.93 0.7 8.01e-51 Parkinson's disease; LUSC cis rs6840360 0.615 rs6836249 chr4:152465829 T/G cg22705602 chr4:152727874 NA -0.32 -6.49 -0.33 3.05e-10 Intelligence (multi-trait analysis); LUSC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -12.68 -0.57 2.3e-30 Hemoglobin concentration; LUSC cis rs1775715 0.737 rs2799017 chr10:32203460 A/G cg03015672 chr10:32216066 ARHGAP12 0.34 6.22 0.32 1.49e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs929354 0.772 rs1182362 chr7:157019535 A/G cg17757837 chr7:157058334 UBE3C -0.82 -13.31 -0.59 1.01e-32 Body mass index; LUSC cis rs929354 0.772 rs3802117 chr7:156987000 C/T cg17757837 chr7:157058334 UBE3C 0.83 13.33 0.59 8.46e-33 Body mass index; LUSC cis rs41271473 1.000 rs55956922 chr1:228872549 T/A cg10167378 chr1:228756711 NA 0.54 6.58 0.34 1.87e-10 Chronic lymphocytic leukemia; LUSC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg11244672 chr19:19639970 YJEFN3 -0.48 -6.39 -0.33 5.44e-10 Tonsillectomy; LUSC cis rs7809950 0.817 rs11535285 chr7:107143866 A/G cg23024343 chr7:107201750 COG5 -0.69 -10.12 -0.48 3.48e-21 Coronary artery disease; LUSC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg11742103 chr11:62369870 EML3;MTA2 0.55 9.02 0.44 1.54e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7572644 0.766 rs12165240 chr2:28172125 A/T cg27432699 chr2:27873401 GPN1 -0.52 -6.52 -0.34 2.64e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6977660 0.943 rs12668201 chr7:19831610 A/C cg07541023 chr7:19748670 TWISTNB -0.56 -6.52 -0.34 2.54e-10 Thyroid stimulating hormone; LUSC cis rs7584330 0.666 rs72620817 chr2:238353661 C/T cg16989719 chr2:238392110 NA -0.42 -6.73 -0.35 7.45e-11 Prostate cancer; LUSC cis rs12421382 0.614 rs12575538 chr11:109390966 C/A cg16359550 chr11:109292809 C11orf87 0.32 5.78 0.3 1.74e-8 Schizophrenia; LUSC trans rs1814175 0.817 rs1615305 chr11:49895222 T/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.92 -0.81 3.6e-78 Height; LUSC cis rs2228479 0.681 rs7199685 chr16:89959805 G/C cg26513180 chr16:89883248 FANCA 0.66 6.64 0.34 1.24e-10 Skin colour saturation; LUSC cis rs7267979 0.966 rs6050611 chr20:25414419 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.81 0.7 2.41e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg09796270 chr17:17721594 SREBF1 0.42 7.36 0.37 1.44e-12 Total body bone mineral density; LUSC cis rs778371 0.723 rs10210953 chr2:233698830 G/A cg08000102 chr2:233561755 GIGYF2 -0.8 -13.87 -0.6 7.07e-35 Schizophrenia; LUSC cis rs9325144 0.513 rs7977596 chr12:38649067 C/A cg13010199 chr12:38710504 ALG10B -0.51 -7.68 -0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.74 12.42 0.56 2.25e-29 Personality dimensions; LUSC cis rs472402 0.560 rs2303705 chr5:6622017 A/C cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.51 -7.54 -0.38 4.39e-13 Response to amphetamines; LUSC cis rs12190007 0.547 rs3006184 chr6:169805128 C/T cg15038512 chr6:170123185 PHF10 -0.38 -6.14 -0.32 2.34e-9 Obesity-related traits; LUSC cis rs10992471 0.756 rs7043152 chr9:95138499 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.2 -0.41 5.21e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9952991 0.941 rs34920518 chr18:12783086 A/G cg23544223 chr18:12777786 NA -0.56 -5.8 -0.3 1.51e-8 Inflammatory skin disease; LUSC cis rs4805272 0.539 rs7256211 chr19:29333063 C/G cg03161606 chr19:29218774 NA 0.49 6.06 0.31 3.67e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg13206674 chr6:150067644 NUP43 0.63 10.08 0.48 4.97e-21 Lung cancer; LUSC cis rs9473147 0.543 rs9473119 chr6:47450618 G/A cg20196966 chr6:47445060 CD2AP 0.42 5.92 0.31 7.99e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs922692 0.715 rs11072803 chr15:79077878 G/A cg00540400 chr15:79124168 NA -0.41 -7.06 -0.36 9.95e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs12421382 0.659 rs35527696 chr11:109379944 T/A cg27471124 chr11:109292789 C11orf87 0.41 7.09 0.36 8.05e-12 Schizophrenia; LUSC cis rs2446066 0.659 rs34109204 chr12:53872283 C/A cg20730629 chr12:53886622 MAP3K12 -0.47 -5.98 -0.31 5.66e-9 Red blood cell count; LUSC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg26513180 chr16:89883248 FANCA 0.91 17.66 0.69 9.25e-50 Vitiligo; LUSC trans rs12145833 0.596 rs12043646 chr1:243281992 G/A cg01826367 chr1:224180288 NA 0.67 6.26 0.32 1.21e-9 Obesity (early onset extreme); LUSC cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg21573476 chr21:45109991 RRP1B -0.41 -6.65 -0.34 1.21e-10 Mean corpuscular volume; LUSC cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg13010199 chr12:38710504 ALG10B 0.64 9.78 0.47 4.83e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs8060686 0.623 rs6499157 chr16:68105474 A/C cg26727032 chr16:67993705 SLC12A4 -0.43 -6.84 -0.35 3.69e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs1784581 0.588 rs6415086 chr6:162418147 C/T cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.09e-20 Itch intensity from mosquito bite; LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg18404041 chr3:52824283 ITIH1 -0.56 -10.64 -0.5 6.05e-23 Bipolar disorder; LUSC cis rs7106204 0.668 rs7951530 chr11:24246904 T/C ch.11.24196551F chr11:24239977 NA 1.14 14.03 0.61 1.83e-35 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7100689 0.577 rs10788545 chr10:82034675 A/G cg00277334 chr10:82204260 NA -0.45 -6.28 -0.32 1.07e-9 Post bronchodilator FEV1; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg07677032 chr17:61819896 STRADA 0.54 8.94 0.44 2.71e-17 Prudent dietary pattern; LUSC cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC cis rs62400317 0.859 rs4498350 chr6:45268438 C/T cg18551225 chr6:44695536 NA -0.43 -7.12 -0.36 6.86e-12 Total body bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18404039 chr20:3184938 DDRGK1 0.46 7.05 0.36 1.01e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9581857 0.615 rs79553479 chr13:28007862 G/A cg22138327 chr13:27999177 GTF3A 0.89 9.45 0.46 6.21e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs6987853 0.787 rs2974351 chr8:42407047 A/T cg09913449 chr8:42400586 C8orf40 0.53 9.22 0.45 3.48e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs4780401 0.539 rs62040604 chr16:11803641 G/A cg01061890 chr16:11836724 TXNDC11 -0.57 -8.54 -0.42 4.96e-16 Rheumatoid arthritis; LUSC cis rs9297145 0.585 rs10953281 chr7:98772131 C/T cg05967295 chr7:98741636 SMURF1 -0.66 -10.71 -0.51 3.21e-23 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg16447950 chr5:562315 NA 0.53 6.6 0.34 1.58e-10 Obesity-related traits; LUSC cis rs8114671 0.647 rs1415771 chr20:33734493 G/A cg24642439 chr20:33292090 TP53INP2 0.4 5.74 0.3 2.08e-8 Height; LUSC trans rs637571 0.522 rs566590 chr11:65754062 C/T cg17712092 chr4:129076599 LARP1B 0.73 11.15 0.52 9.17e-25 Eosinophil percentage of white cells; LUSC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg23625390 chr15:77176239 SCAPER 0.46 7.0 0.36 1.44e-11 Blood metabolite levels; LUSC cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.6 8.84 0.44 5.69e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2455601 0.573 rs2653573 chr11:8989874 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.35 -5.97 -0.31 6.03e-9 Schizophrenia; LUSC cis rs735860 0.687 rs2294852 chr6:53157214 C/G cg10236188 chr6:53219634 NA -0.38 -6.04 -0.31 4.05e-9 Glaucoma; LUSC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg19346786 chr7:2764209 NA -0.43 -7.14 -0.36 5.9e-12 Height; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.79e-30 Prudent dietary pattern; LUSC trans rs62238980 0.614 rs75584049 chr22:32468790 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs12956009 0.518 rs1560902 chr18:44898765 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.44 0.33 4.13e-10 Educational attainment (years of education); LUSC cis rs9462027 0.628 rs2744957 chr6:34618516 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.91 -0.31 8.54e-9 Systemic lupus erythematosus; LUSC cis rs968451 0.906 rs12628367 chr22:39717104 A/C cg17798944 chr22:39715225 SNORD43;RPL3 0.67 8.51 0.42 6.07e-16 Primary biliary cholangitis; LUSC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg11645453 chr3:52864694 ITIH4 0.37 8.58 0.43 3.5e-16 Bipolar disorder; LUSC cis rs6845621 0.901 rs10030946 chr4:18927120 T/C cg12196642 chr4:18937545 NA -0.35 -6.46 -0.33 3.74e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs11148252 0.740 rs9536052 chr13:52960709 C/G cg18335740 chr13:41363409 SLC25A15 -0.56 -8.45 -0.42 9.1e-16 Lewy body disease; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg27280034 chr8:59465622 SDCBP -0.51 -6.56 -0.34 2.04e-10 Neuroticism; LUSC cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg08085267 chr17:45401833 C17orf57 -0.51 -7.29 -0.37 2.22e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs12310956 0.532 rs11052954 chr12:33993512 C/G cg26384229 chr12:38710491 ALG10B 0.7 10.84 0.51 1.12e-23 Morning vs. evening chronotype; LUSC cis rs2073300 0.609 rs6137920 chr20:23363436 C/T cg12062639 chr20:23401060 NAPB 0.92 8.03 0.4 1.65e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7589342 0.831 rs6714861 chr2:106518893 C/T cg16077055 chr2:106428750 NCK2 -0.32 -6.14 -0.32 2.3e-9 Addiction; LUSC cis rs6546550 0.935 rs3771541 chr2:70031797 C/G cg02498382 chr2:70120550 SNRNP27 -0.29 -6.9 -0.35 2.68e-11 Prevalent atrial fibrillation; LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.94e-10 Menopause (age at onset); LUSC cis rs983392 0.805 rs7926344 chr11:59962166 G/A cg20284999 chr11:59952153 MS4A6A -0.39 -6.44 -0.33 4.21e-10 Alzheimer's disease (late onset); LUSC cis rs7264396 0.836 rs41293080 chr20:34187697 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -7.73 -0.39 1.26e-13 Total cholesterol levels; LUSC cis rs11711311 1.000 rs62268168 chr3:113489447 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.71 0.34 8.46e-11 IgG glycosylation; LUSC cis rs240764 0.817 rs239229 chr6:101105975 T/C cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC trans rs1998174 0.509 rs2235696 chr1:171811469 A/T cg13482142 chr2:234261155 NA 0.42 6.02 0.31 4.51e-9 Platelet distribution width; LUSC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC trans rs7937682 1.000 rs505372 chr11:111507189 A/C cg18187862 chr3:45730750 SACM1L 0.57 7.08 0.36 8.31e-12 Primary sclerosing cholangitis; LUSC cis rs9815354 0.680 rs73073296 chr3:42028074 G/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg24675658 chr1:53192096 ZYG11B -0.58 -9.11 -0.45 7.64e-18 Monocyte count; LUSC cis rs7264396 0.635 rs6058378 chr20:34546658 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.83 -0.44 6.04e-17 Total cholesterol levels; LUSC cis rs12579753 0.917 rs12311988 chr12:82177209 C/A cg07988820 chr12:82153109 PPFIA2 -0.41 -5.9 -0.31 9.13e-9 Resting heart rate; LUSC cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.66 0.5 4.93e-23 Bone mineral density; LUSC cis rs7647973 1.000 rs974495 chr3:49400482 T/C cg07636037 chr3:49044803 WDR6 0.71 9.64 0.47 1.48e-19 Menarche (age at onset); LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T cg06583108 chr12:85430029 TSPAN19;LRRIQ1 -0.4 -6.07 -0.32 3.5e-9 Leprosy; LUSC cis rs8044868 0.530 rs2550870 chr16:72070129 C/T cg16579770 chr16:72058938 DHODH 0.35 5.86 0.31 1.08e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26623224 chr19:49661080 TRPM4 -0.49 -5.97 -0.31 5.94e-9 Bipolar disorder and schizophrenia; LUSC cis rs7267979 0.932 rs417130 chr20:25458320 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.21 0.74 6.52e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4974559 0.948 rs3856982 chr4:1328863 C/T cg02980000 chr4:1222292 CTBP1 -0.65 -7.49 -0.38 6.32e-13 Systolic blood pressure; LUSC cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.21 0.37 3.73e-12 Mean platelet volume; LUSC cis rs7945718 1.000 rs7945718 chr11:12748819 A/G cg25843174 chr11:12811716 TEAD1 0.32 7.04 0.36 1.09e-11 Educational attainment (years of education); LUSC cis rs4629180 0.593 rs6707517 chr2:102089878 C/T cg01388757 chr2:102091195 RFX8 -0.44 -7.09 -0.36 7.79e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs72781680 0.800 rs6718635 chr2:24066183 A/C cg20701182 chr2:24300061 SF3B14 0.73 7.42 0.38 9.58e-13 Lymphocyte counts; LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs68170813 0.559 rs1018947 chr7:106851939 A/T cg02696742 chr7:106810147 HBP1 -0.63 -9.56 -0.46 2.67e-19 Coronary artery disease; LUSC cis rs7819412 0.775 rs4841489 chr8:10936811 A/G cg21775007 chr8:11205619 TDH -0.52 -7.56 -0.38 3.9e-13 Triglycerides; LUSC trans rs7819412 0.522 rs10088853 chr8:10987967 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.05 -0.31 3.9e-9 Triglycerides; LUSC cis rs3925075 1.000 rs9674009 chr16:31347541 C/A cg02846316 chr16:31340340 ITGAM 0.36 6.66 0.34 1.11e-10 IgA nephropathy; LUSC cis rs524023 0.914 rs11607663 chr11:64368670 G/C cg19131476 chr11:64387923 NRXN2 -0.39 -10.47 -0.5 2.21e-22 Urate levels in obese individuals; LUSC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg18904891 chr8:8559673 CLDN23 0.42 6.56 0.34 2.05e-10 Mood instability; LUSC cis rs11690935 0.843 rs9784123 chr2:172785005 T/A cg13550731 chr2:172543902 DYNC1I2 -0.8 -12.19 -0.55 1.61e-28 Schizophrenia; LUSC cis rs2721195 0.967 rs11777703 chr8:145703508 G/A cg26752003 chr8:145688521 CYHR1 0.69 11.86 0.54 2.51e-27 Age at first birth; LUSC cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg04586622 chr2:25135609 ADCY3 0.42 8.99 0.44 1.88e-17 Body mass index; LUSC cis rs7909074 1.000 rs1408814 chr10:45399088 A/G cg04218760 chr10:45406644 TMEM72 -0.29 -7.14 -0.36 5.82e-12 Mean corpuscular volume; LUSC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg08219700 chr8:58056026 NA 0.64 7.4 0.38 1.14e-12 Developmental language disorder (linguistic errors); LUSC cis rs10791323 0.633 rs2171006 chr11:133728323 T/C cg15485101 chr11:133734466 NA 0.39 7.36 0.37 1.46e-12 Childhood ear infection; LUSC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.1 14.83 0.63 1.35e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg17691542 chr6:26056736 HIST1H1C 0.52 7.77 0.39 9.47e-14 Height; LUSC cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg02527881 chr3:46936655 PTH1R -0.4 -7.23 -0.37 3.4e-12 Colorectal cancer; LUSC cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg03676636 chr4:99064102 C4orf37 0.36 8.01 0.4 1.97e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1943345 0.642 rs642669 chr11:82892454 A/T cg07047830 chr11:82868014 PCF11 0.65 9.61 0.47 1.78e-19 Obesity-related traits; LUSC cis rs1150668 0.699 rs12214383 chr6:28223731 T/C cg21251018 chr6:28226885 NKAPL -0.34 -6.57 -0.34 1.94e-10 Pubertal anthropometrics; LUSC cis rs7524258 1.000 rs7524258 chr1:7292229 T/C cg07173049 chr1:7289937 CAMTA1 0.34 7.07 0.36 8.94e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs12493885 0.769 rs61791504 chr3:153745537 C/G cg17054900 chr3:154042577 DHX36 -0.63 -6.79 -0.35 5.28e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1499972 0.941 rs62263119 chr3:117630175 T/G cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.95e-8 Schizophrenia; LUSC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.08 -0.4 1.19e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs61931739 0.534 rs12371021 chr12:34062252 T/C cg06521331 chr12:34319734 NA -0.48 -7.7 -0.39 1.56e-13 Morning vs. evening chronotype; LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs10791097 0.667 rs1893019 chr11:130756664 C/G cg12179176 chr11:130786555 SNX19 0.85 14.71 0.63 4.19e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9611519 0.929 rs12484477 chr22:41429084 G/A cg03806693 chr22:41940476 POLR3H -0.51 -6.96 -0.36 1.86e-11 Neuroticism; LUSC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg00316803 chr15:76480434 C15orf27 -0.4 -7.02 -0.36 1.26e-11 Blood metabolite levels; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.72 -0.57 1.64e-30 Alzheimer's disease; LUSC cis rs3820928 0.874 rs12614648 chr2:227785535 G/A cg11843606 chr2:227700838 RHBDD1 -0.55 -8.01 -0.4 1.99e-14 Pulmonary function; LUSC cis rs7771547 0.573 rs546272 chr6:36398562 G/A cg07856975 chr6:36356162 ETV7 0.35 6.26 0.32 1.21e-9 Platelet distribution width; LUSC cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg17507749 chr15:85114479 UBE2QP1 0.56 7.19 0.37 4.23e-12 Schizophrenia; LUSC cis rs7903847 0.642 rs7078004 chr10:99140511 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.33 -0.37 1.78e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg06618935 chr21:46677482 NA 0.39 8.1 0.41 1.02e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg22800045 chr5:56110881 MAP3K1 0.8 10.65 0.5 5.23e-23 Initial pursuit acceleration; LUSC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg27266027 chr21:40555129 PSMG1 0.4 5.88 0.31 1e-8 Cognitive function; LUSC cis rs7188861 0.768 rs1646026 chr16:11382695 C/T cg00044050 chr16:11439710 C16orf75 0.56 6.31 0.33 8.71e-10 HDL cholesterol; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg24101359 chr6:42928495 GNMT 0.38 6.43 0.33 4.49e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs861020 0.630 rs655713 chr1:210006438 C/T cg05527609 chr1:210001259 C1orf107 0.67 9.63 0.47 1.5700000000000001e-19 Orofacial clefts; LUSC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.75 -10.46 -0.5 2.53e-22 Age-related macular degeneration (geographic atrophy); LUSC cis rs6696846 0.765 rs72757524 chr1:205086473 C/T cg21643547 chr1:205240462 TMCC2 -0.41 -7.54 -0.38 4.37e-13 Red blood cell count; LUSC cis rs6681460 0.901 rs1373911 chr1:67041065 T/C cg02459107 chr1:67143332 SGIP1 0.44 7.8 0.39 7.81e-14 Presence of antiphospholipid antibodies; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg09877947 chr5:131593287 PDLIM4 0.58 9.82 0.47 3.56e-20 Acylcarnitine levels; LUSC cis rs3092073 0.624 rs3848719 chr20:44596545 G/A cg17986701 chr20:44574422 PCIF1 0.41 7.18 0.37 4.44e-12 Intelligence (multi-trait analysis); LUSC trans rs6600671 1.000 rs4844607 chr1:121184059 C/T cg09829573 chr1:144692074 NBPF9 0.33 6.32 0.33 8.2e-10 Hip geometry; LUSC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg05754148 chr16:3507555 NAT15 0.83 8.66 0.43 1.98e-16 Tuberculosis; LUSC cis rs8062405 0.755 rs4788078 chr16:28559981 G/A cg07382826 chr16:28625726 SULT1A1 0.28 5.86 0.31 1.14e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg00071950 chr4:10020882 SLC2A9 0.6 9.88 0.48 2.28e-20 Bone mineral density; LUSC cis rs7264396 0.832 rs224378 chr20:34088764 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.23 -0.32 1.44e-9 Total cholesterol levels; LUSC cis rs11169225 0.906 rs3782319 chr12:50345079 G/A cg23855989 chr12:50355821 AQP5 0.72 11.72 0.54 8.32e-27 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7267979 0.966 rs3002698 chr20:25303379 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.01 -0.7 3.71e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg16329197 chr12:53359506 NA -0.67 -9.42 -0.46 7.57e-19 Cancer (pleiotropy); LUSC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg03036452 chr22:46663545 TTC38 0.52 5.7 0.3 2.69e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs7577696 0.962 rs2235134 chr2:32332543 G/A cg02381751 chr2:32503542 YIPF4 -0.4 -5.68 -0.3 2.93e-8 Inflammatory biomarkers; LUSC cis rs3813567 0.759 rs12148319 chr15:78956192 A/G cg04896959 chr15:78267971 NA -0.42 -6.66 -0.34 1.12e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7665147 1 rs7665147 chr4:57767327 T/A cg26694713 chr4:57773883 REST 0.52 6.37 0.33 6.11e-10 Platelet count; LUSC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.72 -0.43 1.28e-16 Electroencephalogram traits; LUSC cis rs6964587 1.000 rs58965837 chr7:91585258 T/A cg22709100 chr7:91322751 NA 0.39 5.78 0.3 1.68e-8 Breast cancer; LUSC cis rs8031584 0.918 rs35396566 chr15:31263057 T/C cg08109568 chr15:31115862 NA -0.67 -9.13 -0.45 6.55e-18 Huntington's disease progression; LUSC cis rs3820928 0.709 rs2894627 chr2:227910171 A/G cg11843606 chr2:227700838 RHBDD1 -0.51 -6.92 -0.35 2.39e-11 Pulmonary function; LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.75 -0.35 6.5e-11 Menopause (age at onset); LUSC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg09034736 chr1:150693464 HORMAD1 0.49 7.13 0.36 6.06e-12 Tonsillectomy; LUSC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg11062466 chr8:58055876 NA 0.52 7.02 0.36 1.27e-11 Developmental language disorder (linguistic errors); LUSC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg23978390 chr7:1156363 C7orf50 0.48 5.75 0.3 2.04e-8 Bronchopulmonary dysplasia; LUSC cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg13535736 chr9:111863775 C9orf5 -0.4 -6.6 -0.34 1.59e-10 Menarche (age at onset); LUSC cis rs2439831 0.867 rs2245715 chr15:43818052 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.86 9.49 0.46 4.43e-19 Lung cancer in ever smokers; LUSC cis rs2281558 1.000 rs2281558 chr20:25240189 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.55 8.16 0.41 7.03e-15 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg17948913 chr5:572064 NA 0.36 6.08 0.32 3.32e-9 Obesity-related traits; LUSC cis rs4474465 1.000 rs7927722 chr11:78210893 T/C cg27205649 chr11:78285834 NARS2 0.54 6.13 0.32 2.46e-9 Alzheimer's disease (survival time); LUSC cis rs11997175 0.624 rs4621768 chr8:33677452 T/C ch.8.33884649F chr8:33765107 NA 0.47 7.1 0.36 7.41e-12 Body mass index; LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg05896524 chr21:47604654 C21orf56 0.54 8.18 0.41 6.04e-15 Testicular germ cell tumor; LUSC cis rs6728861 1 rs6728861 chr2:203873743 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.76 8.22 0.41 4.56e-15 Coronary artery disease; LUSC cis rs4746818 1.000 rs9299502 chr10:70876934 C/T cg11621586 chr10:70884670 VPS26A 1.17 14.83 0.63 1.45e-38 Left atrial antero-posterior diameter; LUSC cis rs7937682 0.855 rs10891285 chr11:111527775 T/C cg22437258 chr11:111473054 SIK2 0.51 6.93 0.35 2.15e-11 Primary sclerosing cholangitis; LUSC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg09509183 chr1:209979624 IRF6 0.52 6.21 0.32 1.61e-9 Cleft lip with or without cleft palate; LUSC cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg16586182 chr3:47516702 SCAP 0.54 8.58 0.43 3.6e-16 Colorectal cancer; LUSC cis rs11098499 1.000 rs11098499 chr4:120187611 C/T cg09307838 chr4:120376055 NA 0.71 10.27 0.49 1.07e-21 Corneal astigmatism; LUSC cis rs859767 0.540 rs6739706 chr2:135407409 A/C cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Neuroticism; LUSC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg00745463 chr17:30367425 LRRC37B -0.85 -10.0 -0.48 8.86e-21 Hip circumference adjusted for BMI; LUSC cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg25208724 chr1:156163844 SLC25A44 1.04 17.84 0.7 1.71e-50 Testicular germ cell tumor; LUSC cis rs7043114 0.525 rs7864630 chr9:95267560 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.7 -0.34 9.03e-11 Height; LUSC cis rs9341808 0.667 rs1575541 chr6:80917485 T/A cg08355045 chr6:80787529 NA 0.46 7.95 0.4 2.94e-14 Sitting height ratio; LUSC cis rs3850699 0.683 rs67481356 chr10:104317811 C/A cg04362960 chr10:104952993 NT5C2 0.52 6.95 0.36 1.88e-11 Prostate cancer; LUSC cis rs4631830 0.720 rs7090326 chr10:51503375 A/T cg10326726 chr10:51549505 MSMB -0.36 -6.3 -0.33 9.62e-10 Prostate-specific antigen levels; LUSC cis rs9287719 0.967 rs6719701 chr2:10748283 G/A cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs427394 1.000 rs182135 chr5:6747453 G/A cg10857441 chr5:6722123 POLS -0.41 -7.72 -0.39 1.38e-13 Menopause (age at onset); LUSC cis rs10771431 0.597 rs7976807 chr12:9352459 G/A cg08997352 chr12:9597637 DDX12 -0.71 -11.07 -0.52 1.83e-24 Breast size; LUSC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg18305652 chr10:134549665 INPP5A 0.45 6.85 0.35 3.46e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.2 -0.32 1.66e-9 Life satisfaction; LUSC cis rs7918232 0.627 rs10829165 chr10:27319465 A/G cg14240646 chr10:27532245 ACBD5 -0.5 -6.98 -0.36 1.56e-11 Breast cancer; LUSC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.56 0.38 3.98e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs4718428 0.672 rs36038499 chr7:66289615 A/G cg18876405 chr7:65276391 NA 0.48 6.42 0.33 4.57e-10 Corneal structure; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg08859206 chr1:53392774 SCP2 -0.57 -10.68 -0.5 4.36e-23 Monocyte count; LUSC cis rs4919694 0.536 rs12414777 chr10:104697781 C/T cg05855489 chr10:104503620 C10orf26 0.55 6.42 0.33 4.69e-10 Arsenic metabolism; LUSC cis rs709400 0.663 rs62007681 chr14:103884651 G/A cg10523860 chr14:103875565 MARK3 -0.39 -6.11 -0.32 2.79e-9 Body mass index; LUSC cis rs6546537 0.869 rs13035491 chr2:69827456 G/A cg10773587 chr2:69614142 GFPT1 -0.54 -8.29 -0.41 2.87e-15 Serum thyroid-stimulating hormone levels; LUSC trans rs1005277 0.522 rs200943 chr10:38148730 A/G cg17830980 chr10:43048298 ZNF37B -0.42 -6.51 -0.34 2.72e-10 Extrinsic epigenetic age acceleration; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg06145435 chr7:1022769 CYP2W1 0.3 6.43 0.33 4.37e-10 Longevity;Endometriosis; LUSC cis rs6693567 0.565 rs3125808 chr1:150314272 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.02 0.36 1.22e-11 Migraine; LUSC cis rs3736594 0.546 rs7571558 chr2:27839832 C/G cg27432699 chr2:27873401 GPN1 0.62 8.48 0.42 7.18e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg21573476 chr21:45109991 RRP1B -0.41 -6.7 -0.34 8.95e-11 Mean corpuscular volume; LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.31 -0.41 2.42e-15 Gut microbiome composition (summer); LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.89 -0.4 4.46e-14 Gut microbiome composition (summer); LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg11060661 chr22:24314208 DDT;DDTL 0.4 6.73 0.35 7.57e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg04155289 chr7:94953770 PON1 -0.35 -5.87 -0.31 1.03e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7241530 0.662 rs1566903 chr18:75901684 T/C cg14642773 chr18:75888474 NA 0.41 6.29 0.33 1.02e-9 Educational attainment (years of education); LUSC cis rs9486719 0.843 rs2472876 chr6:96845723 A/G cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs4969178 0.600 rs4969184 chr17:76393413 G/A cg05887092 chr17:76393375 PGS1 0.66 12.99 0.58 1.59e-31 HDL cholesterol levels; LUSC cis rs9467773 1.000 rs9467774 chr6:26505036 C/A cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.97e-18 Intelligence (multi-trait analysis); LUSC cis rs8072100 0.811 rs9889709 chr17:45445229 C/T cg25173405 chr17:45401733 C17orf57 -0.39 -5.92 -0.31 7.86e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg12386194 chr3:101231763 SENP7 0.45 6.35 0.33 7.23e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg03146154 chr1:46216737 IPP 0.51 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3733418 0.929 rs72697952 chr4:165900928 A/G cg25904183 chr4:165877875 C4orf39;TRIM61 -0.44 -5.65 -0.3 3.4e-8 Obesity-related traits; LUSC trans rs6502050 0.835 rs7503111 chr17:80101587 A/T cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs61931739 0.613 rs1525898 chr12:33904445 G/T cg06521331 chr12:34319734 NA -0.4 -6.46 -0.33 3.72e-10 Morning vs. evening chronotype; LUSC cis rs11625487 0.609 rs78371022 chr14:77971029 G/A cg16049707 chr14:77965284 ISM2 -0.64 -6.58 -0.34 1.85e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs983392 0.678 rs4938933 chr11:60034429 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.17 0.32 1.96e-9 Alzheimer's disease (late onset); LUSC cis rs636291 0.517 rs670666 chr1:10549380 C/T cg17425144 chr1:10567563 PEX14 -0.62 -12.74 -0.57 1.48e-30 Prostate cancer; LUSC trans rs8072100 1.000 rs8065437 chr17:45721653 C/T cg04995722 chr7:26192034 NFE2L3 -0.37 -6.06 -0.31 3.67e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.62 9.46 0.46 5.51e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.1 0.66 1.44e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg06657462 chr10:94608040 EXOC6 0.4 6.01 0.31 4.73e-9 Schizophrenia; LUSC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg05082376 chr22:42548792 NA -0.4 -6.03 -0.31 4.41e-9 Schizophrenia; LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg18404041 chr3:52824283 ITIH1 -0.63 -12.44 -0.56 1.91e-29 Bipolar disorder; LUSC cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg21535247 chr6:8435926 SLC35B3 0.58 9.01 0.44 1.65e-17 Motion sickness; LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg10729496 chr3:10149963 C3orf24 0.57 7.48 0.38 6.62e-13 Alzheimer's disease; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg00149659 chr3:10157352 C3orf10 1.01 14.57 0.62 1.42e-37 Alzheimer's disease; LUSC cis rs9296092 0.522 rs62405955 chr6:33527176 T/C cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs1371867 0.875 rs962452 chr8:101331369 G/A cg00191853 chr8:101177733 SPAG1 -0.39 -6.47 -0.33 3.49e-10 Atrioventricular conduction; LUSC cis rs9309473 0.519 rs2421667 chr2:73832459 T/C cg20560298 chr2:73613845 ALMS1 0.51 7.82 0.39 7e-14 Metabolite levels; LUSC cis rs12410462 1.000 rs12410243 chr1:227669474 A/G cg23173402 chr1:227635558 NA 0.57 7.22 0.37 3.53e-12 Major depressive disorder; LUSC cis rs7903847 0.642 rs1537645 chr10:99149914 T/C cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.66e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg04248312 chr19:17393744 ANKLE1 1.0 17.23 0.69 4.97e-48 Systemic lupus erythematosus; LUSC cis rs7539409 0.651 rs910182 chr1:84297117 A/G cg10977910 chr1:84465055 TTLL7 0.68 7.19 0.37 4.25e-12 Alzheimer's disease; LUSC cis rs1044826 0.957 rs4683799 chr3:139210258 G/C cg00490450 chr3:139108681 COPB2 0.51 7.12 0.36 6.45e-12 Obesity-related traits; LUSC cis rs1728785 1.000 rs11075680 chr16:68565700 G/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.23 0.52 4.78e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1595825 0.678 rs57265854 chr2:198917263 C/A cg00982548 chr2:198649783 BOLL -0.56 -6.87 -0.35 3.09e-11 Ulcerative colitis; LUSC cis rs9303401 0.659 rs17222691 chr17:56771096 C/T cg25039879 chr17:56429692 SUPT4H1 0.7 9.21 0.45 3.73e-18 Cognitive test performance; LUSC cis rs17270561 0.609 rs4712961 chr6:25727334 C/T cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC cis rs8060686 0.545 rs9931987 chr16:68256639 G/A cg27539214 chr16:67997921 SLC12A4 -0.52 -6.77 -0.35 5.69e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.46 -0.5 2.48e-22 Alzheimer's disease; LUSC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg04553112 chr3:125709451 NA -0.48 -5.76 -0.3 1.92e-8 Blood pressure (smoking interaction); LUSC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg01879757 chr17:41196368 BRCA1 -0.46 -7.1 -0.36 7.39e-12 Menopause (age at onset); LUSC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg25319279 chr11:5960081 NA -0.37 -5.83 -0.3 1.3e-8 DNA methylation (variation); LUSC cis rs1023500 0.596 rs5758562 chr22:42448238 C/G cg04733989 chr22:42467013 NAGA 0.63 9.9 0.48 1.95e-20 Schizophrenia; LUSC cis rs981844 0.714 rs2405204 chr4:154705248 A/G cg14289246 chr4:154710475 SFRP2 -0.5 -7.04 -0.36 1.12e-11 Response to statins (LDL cholesterol change); LUSC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg09034736 chr1:150693464 HORMAD1 0.41 5.72 0.3 2.38e-8 Melanoma; LUSC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.86e-12 Blood metabolite levels; LUSC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg14895029 chr7:2775587 GNA12 -0.4 -6.14 -0.32 2.36e-9 Height; LUSC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg16989086 chr20:62203971 PRIC285 0.45 6.34 0.33 7.32e-10 Glioblastoma; LUSC trans rs6600671 0.902 rs2222371 chr1:121289118 T/C cg00646200 chr1:148855367 NA -0.51 -7.88 -0.4 4.75e-14 Hip geometry; LUSC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg18350739 chr11:68623251 NA -0.38 -6.61 -0.34 1.56e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7666738 0.519 rs11732209 chr4:98801643 A/G cg17366294 chr4:99064904 C4orf37 0.56 8.94 0.44 2.61e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7074356 0.915 rs17617970 chr10:82206892 A/G cg00277334 chr10:82204260 NA -0.66 -6.19 -0.32 1.8e-9 Borderline personality disorder; LUSC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11644478 chr21:40555479 PSMG1 -0.78 -13.85 -0.6 8.68e-35 Cognitive function; LUSC cis rs11018904 0.768 rs56160356 chr11:89987280 G/C cg26138821 chr11:89956704 CHORDC1 -0.59 -6.72 -0.35 7.83e-11 Intelligence (multi-trait analysis); LUSC cis rs6690583 0.524 rs12029690 chr1:85452867 C/G cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.02e-10 Serum sulfate level; LUSC cis rs1729951 0.575 rs10935213 chr3:136693459 A/G cg12473912 chr3:136751656 NA 0.39 6.82 0.35 4.29e-11 Neuroticism; LUSC cis rs7843479 0.526 rs34802507 chr8:21773853 C/T cg17168535 chr8:21777572 XPO7 0.72 12.24 0.56 1.06e-28 Mean corpuscular volume; LUSC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg06808227 chr14:105710500 BRF1 -0.66 -10.31 -0.49 8.06e-22 Platelet count; LUSC cis rs9467773 0.584 rs1021372 chr6:26632444 T/C cg05738196 chr6:26577821 NA 0.78 14.95 0.63 4.82e-39 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.521 rs4451268 chr8:11034859 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.8 -0.35 4.79e-11 Triglycerides; LUSC cis rs4660306 0.961 rs4660867 chr1:45986484 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.53 -0.34 2.48e-10 Homocysteine levels; LUSC trans rs4674124 1.000 rs35304811 chr2:217759271 C/G cg18563886 chr10:135203102 PAOX -0.47 -6.53 -0.34 2.5e-10 Breast cancer; LUSC cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg03146154 chr1:46216737 IPP -0.5 -7.26 -0.37 2.69e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.79 0.7 2.73e-50 Chronic sinus infection; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg04814837 chr3:133380720 TOPBP1 0.66 6.04 0.31 4.22e-9 Body mass index; LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg02773041 chr1:40204384 PPIE 0.54 8.26 0.41 3.35e-15 Blood protein levels; LUSC cis rs16854884 1.000 rs17668478 chr3:143794370 G/A cg06585982 chr3:143692056 C3orf58 0.45 6.1 0.32 2.86e-9 Economic and political preferences (feminism/equality); LUSC cis rs41271473 1.000 rs11580020 chr1:228880466 A/G cg16512390 chr1:228756714 NA -0.5 -6.1 -0.32 2.93e-9 Chronic lymphocytic leukemia; LUSC cis rs6845621 0.901 rs1377151 chr4:18922884 A/C cg12196642 chr4:18937545 NA -0.38 -7.23 -0.37 3.39e-12 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg10523679 chr1:76189770 ACADM 0.91 15.83 0.65 1.68e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.6 0.65 1.31e-41 Bladder cancer; LUSC cis rs12579753 1.000 rs12830268 chr12:82233627 A/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg18538332 chr22:24372958 LOC391322 -0.46 -8.24 -0.41 3.91e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs72781680 0.651 rs13019016 chr2:23894773 C/G cg08917208 chr2:24149416 ATAD2B 0.86 9.19 0.45 4.2e-18 Lymphocyte counts; LUSC cis rs7927771 0.524 rs7107792 chr11:47669249 A/C cg20307385 chr11:47447363 PSMC3 0.45 6.59 0.34 1.7e-10 Subjective well-being; LUSC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg25258033 chr6:167368657 RNASET2 -0.5 -8.24 -0.41 3.98e-15 Crohn's disease; LUSC cis rs2067615 0.560 rs1882542 chr12:107070049 A/C cg15890332 chr12:107067104 RFX4 0.33 5.92 0.31 7.86e-9 Heart rate; LUSC cis rs240764 0.658 rs4840147 chr6:101182323 T/C cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.54e-10 Neuroticism; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 21.31 0.76 3.25e-64 Prudent dietary pattern; LUSC cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg12011299 chr4:100065546 ADH4 -0.7 -10.69 -0.51 3.76e-23 Alcohol dependence; LUSC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.92 -0.31 7.93e-9 Neutrophil percentage of white cells; LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg10802521 chr3:52805072 NEK4 -0.47 -6.84 -0.35 3.7e-11 Bipolar disorder; LUSC cis rs61931739 0.517 rs4931771 chr12:34044557 G/A cg06521331 chr12:34319734 NA -0.48 -7.71 -0.39 1.43e-13 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.72 -0.35 7.68e-11 Developmental language disorder (linguistic errors); LUSC cis rs6598955 0.724 rs7526545 chr1:26569990 C/A cg04990556 chr1:26633338 UBXN11 -0.8 -14.93 -0.63 5.85e-39 Obesity-related traits; LUSC cis rs1728785 0.892 rs1103955 chr16:68588488 T/G cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.4e-10 Ulcerative colitis; LUSC cis rs459571 0.959 rs408307 chr9:136892523 A/G cg13789015 chr9:136890014 NCRNA00094 -0.69 -12.52 -0.57 9.13e-30 Platelet distribution width; LUSC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg20744362 chr22:50050164 C22orf34 0.39 8.01 0.4 1.96e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg08270630 chr22:50330655 NA 0.41 6.06 0.31 3.64e-9 Schizophrenia; LUSC cis rs6669919 0.553 rs12733443 chr1:211667751 C/T cg10512769 chr1:211675356 NA -0.29 -6.94 -0.36 1.99e-11 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15947940 chr1:39957129 BMP8A 0.68 6.06 0.31 3.67e-9 Cognitive performance; LUSC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg04369109 chr6:150039330 LATS1 -0.55 -8.22 -0.41 4.54e-15 Lung cancer; LUSC cis rs7799006 0.606 rs4721527 chr7:2306655 G/A cg02951883 chr7:2050386 MAD1L1 -0.35 -5.64 -0.3 3.54e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6754311 0.773 rs680428 chr2:136630757 A/G cg07169764 chr2:136633963 MCM6 -0.57 -7.67 -0.39 1.95e-13 Mosquito bite size; LUSC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg20307385 chr11:47447363 PSMC3 0.44 5.68 0.3 2.95e-8 Subjective well-being; LUSC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg06022373 chr22:39101656 GTPBP1 0.84 14.01 0.61 2.17e-35 Menopause (age at onset); LUSC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg06022373 chr22:39101656 GTPBP1 0.77 11.96 0.55 1.1e-27 Menopause (age at onset); LUSC cis rs8040855 0.559 rs6496801 chr15:85728399 G/A cg04831495 chr15:85060580 GOLGA6L5 0.49 7.86 0.39 5.5e-14 Bulimia nervosa; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08979737 chr8:97505843 SDC2 -0.48 -6.47 -0.33 3.49e-10 Bipolar disorder and schizophrenia; LUSC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg06850241 chr22:41845214 NA 0.34 6.22 0.32 1.49e-9 Vitiligo; LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg25072359 chr17:41440525 NA 0.64 8.98 0.44 1.97e-17 Menopause (age at onset); LUSC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs11098499 0.954 rs12508504 chr4:120410607 A/C cg09307838 chr4:120376055 NA 0.78 11.76 0.54 5.79e-27 Corneal astigmatism; LUSC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.93 0.35 2.23e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs7771547 0.573 rs546353 chr6:36398597 C/A cg07856975 chr6:36356162 ETV7 0.34 6.17 0.32 1.93e-9 Platelet distribution width; LUSC cis rs1395 0.744 rs11126935 chr2:27476740 G/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.57 0.38 3.75e-13 Blood metabolite levels; LUSC cis rs8051149 0.688 rs16943320 chr16:87870379 A/G cg01412419 chr16:87856264 NA 0.47 7.43 0.38 9.11e-13 Blood metabolite levels; LUSC cis rs4713675 0.584 rs6917140 chr6:33678394 C/G cg14003231 chr6:33640908 ITPR3 0.29 5.69 0.3 2.82e-8 Plateletcrit; LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -6.47 -0.33 3.47e-10 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.65 -0.54 1.53e-26 Schizophrenia; LUSC cis rs41271473 0.526 rs1925720 chr1:228728377 G/C cg10167378 chr1:228756711 NA 0.76 9.78 0.47 5.16e-20 Chronic lymphocytic leukemia; LUSC cis rs921968 0.541 rs642520 chr2:219423605 A/G cg02176678 chr2:219576539 TTLL4 -0.74 -14.69 -0.63 5.13e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs1505368 0.837 rs10167244 chr2:213281310 A/G cg16329650 chr2:213403929 ERBB4 0.57 9.7 0.47 9.17e-20 Symmetrical dimethylarginine levels; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg08859206 chr1:53392774 SCP2 0.5 8.58 0.43 3.56e-16 Monocyte count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18815006 chr10:71906516 TYSND1 0.77 6.03 0.31 4.25e-9 Cognitive performance; LUSC cis rs1577917 0.917 rs4707226 chr6:86527828 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs877282 0.945 rs11253390 chr10:788678 A/G cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs9463078 0.528 rs12196818 chr6:44911414 G/A cg25276700 chr6:44698697 NA 0.28 5.8 0.3 1.55e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg09034736 chr1:150693464 HORMAD1 0.42 5.82 0.3 1.42e-8 Melanoma; LUSC cis rs2762353 0.845 rs35720558 chr6:25784800 A/C cg12310025 chr6:25882481 NA 0.43 7.36 0.37 1.49e-12 Blood metabolite levels; LUSC cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg05025164 chr4:1340916 KIAA1530 0.41 6.35 0.33 6.97e-10 Obesity-related traits; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg08888203 chr3:10149979 C3orf24 0.65 8.96 0.44 2.4e-17 Alzheimer's disease; LUSC cis rs1355223 0.867 rs3818514 chr11:34680053 G/A cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.86 -0.31 1.13e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg22442454 chr1:209979470 IRF6 0.43 5.88 0.31 9.86e-9 Cleft lip with or without cleft palate; LUSC trans rs72674100 1.000 rs17026369 chr4:97989437 C/G cg09670535 chr1:18959427 PAX7 -0.62 -6.34 -0.33 7.58e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg08392591 chr16:89556376 ANKRD11 0.52 8.19 0.41 5.69e-15 Multiple myeloma (IgH translocation); LUSC cis rs936229 0.705 rs936227 chr15:75131959 A/G cg14664628 chr15:75095509 CSK -0.74 -12.13 -0.55 2.7e-28 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.87 -0.4 5.04e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs600231 0.665 rs2846861 chr11:65222305 A/G cg21890820 chr11:65308645 LTBP3 0.51 7.65 0.39 2.21e-13 Bone mineral density; LUSC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9300255 0.679 rs4759409 chr12:123719585 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.05 -0.31 3.97e-9 Neutrophil percentage of white cells; LUSC cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg03264133 chr6:25882463 NA -0.5 -9.15 -0.45 5.96e-18 Blood metabolite levels; LUSC cis rs6489882 0.867 rs4766663 chr12:113362974 C/T cg20102336 chr12:113376681 OAS3 0.43 6.05 0.31 3.79e-9 Chronic lymphocytic leukemia; LUSC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg25174290 chr11:3078921 CARS 0.6 9.47 0.46 5.17e-19 Longevity; LUSC cis rs559928 0.606 rs11600628 chr11:63976027 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.47 0.38 7.1e-13 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4423214 1.000 rs28364617 chr11:71159764 T/G cg05163923 chr11:71159392 DHCR7 0.75 11.16 0.52 8.43e-25 Vitamin D levels; LUSC cis rs2204008 0.540 rs3908193 chr12:38410907 G/T cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.06e-10 Bladder cancer; LUSC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.82 -0.39 7.18e-14 Crohn's disease; LUSC cis rs9304742 0.962 rs12459008 chr19:53454789 A/T cg09915433 chr19:53449742 NA 0.61 9.77 0.47 5.55e-20 Psoriasis; LUSC cis rs5769765 0.913 rs28670284 chr22:50221973 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.81 -10.13 -0.48 3.2e-21 Schizophrenia; LUSC cis rs12421382 0.659 rs1837396 chr11:109389257 G/A cg27471124 chr11:109292789 C11orf87 0.38 6.94 0.35 2.08e-11 Schizophrenia; LUSC cis rs9309473 0.519 rs13022145 chr2:73863473 G/A cg20560298 chr2:73613845 ALMS1 0.43 6.51 0.34 2.7e-10 Metabolite levels; LUSC cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg18132916 chr6:79620363 NA -0.37 -5.73 -0.3 2.28e-8 Intelligence (multi-trait analysis); LUSC cis rs79149102 0.579 rs7172065 chr15:75321910 C/T cg09165964 chr15:75287851 SCAMP5 -0.93 -7.92 -0.4 3.52e-14 Lung cancer; LUSC cis rs977987 0.832 rs37597 chr16:75500275 T/G cg04384234 chr16:75411784 CFDP1 0.5 8.1 0.41 1.02e-14 Dupuytren's disease; LUSC cis rs2040771 0.745 rs2283646 chr22:19273902 A/G cg02655711 chr22:19163373 SLC25A1 -0.43 -7.69 -0.39 1.61e-13 Metabolite levels (small molecules and protein measures); LUSC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg15468180 chr1:107600409 PRMT6 0.42 6.66 0.34 1.1e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg18230493 chr5:56204884 C5orf35 -0.58 -9.05 -0.44 1.21e-17 Coronary artery disease; LUSC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg08219700 chr8:58056026 NA 0.56 6.75 0.35 6.65e-11 Developmental language disorder (linguistic errors); LUSC cis rs2427308 0.607 rs1741635 chr20:60938197 C/G cg24112000 chr20:60950667 NA 0.36 5.75 0.3 2.05e-8 Colorectal cancer; LUSC cis rs2274273 0.774 rs17128440 chr14:55861912 C/T cg04306507 chr14:55594613 LGALS3 0.56 12.61 0.57 4.38e-30 Protein biomarker; LUSC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg13206674 chr6:150067644 NUP43 0.57 8.94 0.44 2.75e-17 Lung cancer; LUSC cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg23992470 chr4:843637 GAK 0.53 5.66 0.3 3.33e-8 Intelligence (multi-trait analysis); LUSC cis rs17102423 1.000 rs4902365 chr14:65602064 T/C cg11161011 chr14:65562177 MAX -0.63 -9.73 -0.47 7.53e-20 Obesity-related traits; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg10802521 chr3:52805072 NEK4 -0.43 -6.56 -0.34 2.04e-10 Electroencephalogram traits; LUSC cis rs75229567 0.717 rs17107156 chr12:70234066 A/G cg10114359 chr12:70132523 RAB3IP -1.03 -9.55 -0.46 2.89e-19 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg11244672 chr19:19639970 YJEFN3 -0.56 -7.19 -0.37 4.18e-12 Bipolar disorder; LUSC cis rs3784262 1.000 rs12915901 chr15:58279432 G/A cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.68 -0.3 2.94e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs4356932 1.000 rs4309862 chr4:76945981 A/G cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg13683864 chr3:40499215 RPL14 -0.97 -16.18 -0.66 7.23e-44 Renal cell carcinoma; LUSC cis rs7945705 0.875 rs10769947 chr11:8758114 A/G cg12365402 chr11:9010492 NRIP3 0.4 7.02 0.36 1.28e-11 Hemoglobin concentration; LUSC cis rs3008870 0.727 rs11208971 chr1:67383901 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.5 0.56 1.09e-29 Lymphocyte percentage of white cells; LUSC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg03233332 chr7:66118400 NA 0.43 6.16 0.32 2.06e-9 Aortic root size; LUSC cis rs6964587 0.967 rs7781221 chr7:91664645 A/G cg17063962 chr7:91808500 NA 0.6 9.41 0.46 8.58e-19 Breast cancer; LUSC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg11764359 chr7:65958608 NA -0.68 -10.76 -0.51 2.17e-23 Aortic root size; LUSC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg00933542 chr6:150070202 PCMT1 0.28 5.87 0.31 1.08e-8 Lung cancer; LUSC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg06494592 chr3:125709126 NA -0.52 -5.93 -0.31 7.44e-9 Blood pressure (smoking interaction); LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg12016809 chr21:47604291 C21orf56 -0.45 -6.71 -0.34 8.23e-11 Testicular germ cell tumor; LUSC cis rs7177699 0.534 rs7403708 chr15:79123885 T/C cg00540400 chr15:79124168 NA -0.47 -8.15 -0.41 7.33e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7589342 0.831 rs34554853 chr2:106448931 G/A cg16077055 chr2:106428750 NCK2 0.37 7.05 0.36 1.01e-11 Addiction; LUSC cis rs10197940 0.578 rs1061305 chr2:152346979 T/C cg19508488 chr2:152266495 RIF1 0.4 5.87 0.31 1.02e-8 Lung cancer; LUSC cis rs614226 0.744 rs787832 chr12:120986801 A/G cg27489772 chr12:121021490 NA 0.59 7.72 0.39 1.4e-13 Type 1 diabetes nephropathy; LUSC cis rs77741769 0.700 rs61946385 chr12:121362330 G/A cg02403541 chr12:121454288 C12orf43 0.49 7.33 0.37 1.71e-12 Mean corpuscular volume; LUSC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg11861562 chr11:117069780 TAGLN 0.35 6.87 0.35 3.18e-11 Blood protein levels; LUSC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.71 11.14 0.52 9.82e-25 Monocyte percentage of white cells; LUSC cis rs11122272 0.735 rs2024878 chr1:231528415 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.64 10.05 0.48 6.01e-21 Hemoglobin concentration; LUSC cis rs11166629 0.637 rs4909475 chr8:135557622 A/G cg27224718 chr8:135614730 ZFAT 0.52 7.46 0.38 7.47e-13 Smoking quantity; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg21280719 chr6:42927975 GNMT -0.31 -7.86 -0.4 5.18e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg09835421 chr16:68378352 PRMT7 -0.54 -6.09 -0.32 3.03e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs66887589 0.967 rs56173225 chr4:120509972 G/A cg24375607 chr4:120327624 NA -0.47 -7.23 -0.37 3.29e-12 Diastolic blood pressure; LUSC cis rs1670533 1.000 rs6821725 chr4:1060360 C/G cg27284194 chr4:1044797 NA 0.59 8.61 0.43 3.01e-16 Recombination rate (females); LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg24060327 chr5:131705240 SLC22A5 -0.41 -6.49 -0.33 3.04e-10 Blood metabolite levels; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg24153548 chr3:100119764 LNP1;TOMM70A 0.39 5.97 0.31 6.03e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs722599 0.683 rs17102847 chr14:75324780 A/G cg06637938 chr14:75390232 RPS6KL1 -0.4 -5.8 -0.3 1.58e-8 IgG glycosylation; LUSC cis rs2692947 0.644 rs3821051 chr2:96912787 A/G cg23100626 chr2:96804247 ASTL -0.27 -6.69 -0.34 9.6e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs3820928 0.874 rs10195072 chr2:227794452 G/A cg11843606 chr2:227700838 RHBDD1 -0.51 -7.57 -0.38 3.71e-13 Pulmonary function; LUSC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg24838063 chr12:130822603 PIWIL1 0.71 11.02 0.52 2.72e-24 Menopause (age at onset); LUSC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg05802129 chr4:122689817 NA -0.52 -8.78 -0.43 8.4e-17 Type 2 diabetes; LUSC cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg22875332 chr1:76189707 ACADM -0.42 -6.15 -0.32 2.24e-9 Daytime sleep phenotypes; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg16325326 chr1:53192061 ZYG11B 0.73 12.8 0.57 8.52e-31 Monocyte count; LUSC cis rs10761482 1.000 rs1340652 chr10:62078203 C/T cg18175470 chr10:62150864 ANK3 0.46 6.51 0.34 2.74e-10 Schizophrenia; LUSC cis rs754466 0.958 rs11002341 chr10:79701363 A/C cg17075019 chr10:79541650 NA -0.61 -7.96 -0.4 2.75e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1941687 0.527 rs6507059 chr18:31303643 A/G cg27147174 chr7:100797783 AP1S1 -0.46 -7.08 -0.36 8.37e-12 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg04450456 chr4:17643702 FAM184B 0.39 6.54 0.34 2.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4595586 0.545 rs6580889 chr12:39369742 T/C cg26384229 chr12:38710491 ALG10B 0.49 6.91 0.35 2.53e-11 Morning vs. evening chronotype; LUSC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg09085632 chr11:111637200 PPP2R1B -1.04 -17.01 -0.68 3.62e-47 Primary sclerosing cholangitis; LUSC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg14019146 chr3:50243930 SLC38A3 0.32 7.03 0.36 1.19e-11 Intelligence (multi-trait analysis); LUSC cis rs2295359 0.892 rs11209005 chr1:67618678 A/G cg17031739 chr1:67600172 NA 0.45 7.1 0.36 7.53e-12 Psoriasis; LUSC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg06219351 chr7:158114137 PTPRN2 -0.61 -11.27 -0.52 3.4e-25 Calcium levels; LUSC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg06634786 chr22:41940651 POLR3H 0.51 5.87 0.31 1.04e-8 Cannabis dependence symptom count; LUSC cis rs2274273 0.837 rs10141483 chr14:55786871 T/C cg04306507 chr14:55594613 LGALS3 0.56 12.99 0.58 1.58e-31 Protein biomarker; LUSC cis rs9467711 0.659 rs72845428 chr6:26550144 C/T cg09904177 chr6:26538194 HMGN4 -0.77 -6.04 -0.31 4.1e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs314370 0.570 rs314313 chr7:100423365 C/T cg10426581 chr7:100472382 SRRT -0.5 -7.95 -0.4 2.88e-14 Resting heart rate; LUSC cis rs6964587 1.000 rs2299240 chr7:91654618 A/G cg17063962 chr7:91808500 NA 0.57 9.07 0.44 1.02e-17 Breast cancer; LUSC cis rs9911578 0.967 rs2333410 chr17:57137129 G/A cg05425664 chr17:57184151 TRIM37 0.56 8.71 0.43 1.42e-16 Intelligence (multi-trait analysis); LUSC cis rs4144743 1.000 rs7224990 chr17:45326878 C/T cg18085866 chr17:45331354 ITGB3 -0.75 -7.79 -0.39 8.26e-14 Body mass index; LUSC cis rs9807989 0.839 rs3771166 chr2:102986222 G/A cg03938978 chr2:103052716 IL18RAP 0.31 5.68 0.3 2.87e-8 Asthma; LUSC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg11843238 chr5:131593191 PDLIM4 0.37 6.31 0.33 8.89e-10 Breast cancer; LUSC trans rs9944715 0.906 rs4453596 chr18:43749826 T/C cg01718231 chr17:29326311 RNF135 0.48 6.76 0.35 6.1e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg08999081 chr20:33150536 PIGU 0.37 6.81 0.35 4.61e-11 Height; LUSC cis rs796364 0.539 rs6738494 chr2:200697058 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.55 6.38 0.33 5.95e-10 Schizophrenia; LUSC trans rs2243480 1.000 rs35825738 chr7:65318027 A/G cg10756647 chr7:56101905 PSPH 0.87 8.43 0.42 1.06e-15 Diabetic kidney disease; LUSC cis rs78572108 0.858 rs4952581 chr2:42268444 T/C cg00607755 chr2:42274082 PKDCC 0.35 5.98 0.31 5.72e-9 Total body bone mineral density; LUSC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg18240062 chr17:79603768 NPLOC4 0.79 15.38 0.64 9.93e-41 Eye color traits; LUSC trans rs11696501 0.739 rs6073822 chr20:44251880 A/G cg03272292 chr12:48577362 C12orf68 0.49 5.99 0.31 5.29e-9 Brain structure; LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg21782813 chr7:2030301 MAD1L1 0.57 10.0 0.48 9.04e-21 Bipolar disorder and schizophrenia; LUSC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg16339924 chr4:17578868 LAP3 0.5 7.63 0.39 2.45e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7618501 1.000 rs7649348 chr3:49772375 G/A cg24110177 chr3:50126178 RBM5 0.42 6.73 0.35 7.18e-11 Intelligence (multi-trait analysis); LUSC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.48 6.12 0.32 2.56e-9 Multiple sclerosis; LUSC trans rs3960554 1.000 rs3960554 chr7:75845597 G/T cg19862616 chr7:65841803 NCRNA00174 0.84 9.06 0.44 1.14e-17 Eotaxin levels; LUSC cis rs2219968 1.000 rs6982916 chr8:78972362 A/G cg00738934 chr8:78996279 NA -0.33 -5.83 -0.3 1.31e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs2742540 0.524 rs2653562 chr11:8918160 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.38 -6.66 -0.34 1.11e-10 Hematocrit; LUSC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.53 0.38 4.68e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs12310956 0.515 rs1405031 chr12:33958931 A/C cg13010199 chr12:38710504 ALG10B 0.49 7.38 0.37 1.28e-12 Morning vs. evening chronotype; LUSC cis rs12541635 0.966 rs4734895 chr8:107002604 A/G cg10147462 chr8:107024639 NA 0.55 9.76 0.47 5.68e-20 Age of smoking initiation; LUSC cis rs2120019 0.608 rs8042558 chr15:75320433 G/T cg09165964 chr15:75287851 SCAMP5 -1.07 -17.68 -0.7 7.92e-50 Blood trace element (Zn levels); LUSC cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg15485101 chr11:133734466 NA -0.42 -7.77 -0.39 9.49e-14 Childhood ear infection; LUSC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg11965913 chr1:205819406 PM20D1 0.49 6.75 0.35 6.52e-11 Parkinson's disease; LUSC cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg22467129 chr15:76604101 ETFA -0.43 -6.8 -0.35 4.84e-11 Blood metabolite levels; LUSC cis rs3008870 0.959 rs2985816 chr1:67387750 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.08 0.64 1.48e-39 Lymphocyte percentage of white cells; LUSC trans rs1728785 1.000 rs7195979 chr16:68586801 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.46 0.42 8.65e-16 Ulcerative colitis; LUSC cis rs7575217 1.000 rs7575217 chr2:101776932 A/G cg23907051 chr2:101730305 TBC1D8 -0.27 -6.94 -0.36 2.04e-11 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg06740227 chr12:86229804 RASSF9 -0.4 -6.57 -0.34 1.88e-10 Major depressive disorder; LUSC cis rs10992471 0.651 rs2296669 chr9:95373790 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.42 7.07 0.36 9.08e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9300255 0.602 rs1790131 chr12:123701010 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg11235426 chr6:292522 DUSP22 -0.45 -6.77 -0.35 5.86e-11 Menopause (age at onset); LUSC cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg06494592 chr3:125709126 NA -0.51 -6.36 -0.33 6.53e-10 Blood pressure (smoking interaction); LUSC cis rs10207060 0.771 rs4852124 chr2:240680022 C/T cg20333904 chr2:240724165 NA -0.41 -7.27 -0.37 2.58e-12 Obesity-related traits; LUSC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg24846343 chr22:24311635 DDTL 0.76 17.17 0.68 8.03e-48 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg08392591 chr16:89556376 ANKRD11 0.52 8.06 0.4 1.35e-14 Multiple myeloma (IgH translocation); LUSC cis rs780094 0.585 rs7586601 chr2:27584666 A/G cg22903471 chr2:27725779 GCKR -0.42 -7.2 -0.37 3.91e-12 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs6500602 0.964 rs2304633 chr16:4496973 T/A cg08645402 chr16:4508243 NA 0.53 8.74 0.43 1.16e-16 Schizophrenia; LUSC cis rs6582630 0.538 rs7971292 chr12:38498151 A/G cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.06e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2439831 0.702 rs3784275 chr15:44091386 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.92 8.48 0.42 7.5e-16 Lung cancer in ever smokers; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg16606324 chr3:10149918 C3orf24 0.6 8.0 0.4 2.03e-14 Alzheimer's disease; LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg13012494 chr21:47604986 C21orf56 -0.51 -7.81 -0.39 7.43e-14 Testicular germ cell tumor; LUSC cis rs79349575 0.715 rs62075844 chr17:47002389 G/A cg22482690 chr17:47019901 SNF8 0.39 7.38 0.37 1.3e-12 Type 2 diabetes; LUSC cis rs12313068 0.600 rs7136207 chr12:110491487 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 9.83 0.47 3.52e-20 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.62e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg18876405 chr7:65276391 NA -0.56 -8.96 -0.44 2.27e-17 Aortic root size; LUSC cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg03146154 chr1:46216737 IPP 0.51 7.55 0.38 4.21e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18047607 chr2:15701435 NBAS -0.44 -6.64 -0.34 1.3e-10 Hepatitis; LUSC cis rs965469 1.000 rs6037583 chr20:3360632 G/A cg25506879 chr20:3388711 C20orf194 -0.52 -5.68 -0.3 2.97e-8 IFN-related cytopenia; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg13560548 chr3:10150139 C3orf24 0.48 6.6 0.34 1.6e-10 Alzheimer's disease; LUSC cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg10968187 chr4:17616003 MED28 -0.4 -5.77 -0.3 1.86e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs585510 1 rs585510 chr12:121000133 A/G cg12219531 chr12:120966889 COQ5 0.64 8.67 0.43 1.86e-16 Reticulocyte fraction of red cells; LUSC cis rs7845219 0.539 rs10441538 chr8:95868608 G/A cg16049864 chr8:95962084 TP53INP1 -0.51 -8.96 -0.44 2.35e-17 Type 2 diabetes; LUSC cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg12386194 chr3:101231763 SENP7 0.63 8.57 0.42 3.76e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg18230493 chr5:56204884 C5orf35 -0.77 -12.11 -0.55 3.02e-28 Coronary artery disease; LUSC trans rs1493916 0.967 rs9953768 chr18:31399468 A/G cg27147174 chr7:100797783 AP1S1 -0.64 -10.28 -0.49 1.02e-21 Life satisfaction; LUSC cis rs2377585 0.524 rs35146959 chr12:8847546 C/T cg03761649 chr12:8850719 RIMKLB 0.48 6.42 0.33 4.77e-10 Reticulocyte fraction of red cells; LUSC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.69 -10.67 -0.5 4.58e-23 Platelet count; LUSC cis rs4654899 0.865 rs12131353 chr1:21321163 C/G cg01072550 chr1:21505969 NA -0.5 -7.4 -0.38 1.14e-12 Superior frontal gyrus grey matter volume; LUSC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg19592336 chr6:28129416 ZNF389 0.45 5.81 0.3 1.46e-8 Depression; LUSC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg14829155 chr15:31115871 NA -0.56 -7.84 -0.39 6.22e-14 Huntington's disease progression; LUSC cis rs11997175 0.574 rs12541661 chr8:33649856 T/G ch.8.33884649F chr8:33765107 NA 0.51 8.34 0.42 1.94e-15 Body mass index; LUSC cis rs9790314 0.905 rs1154701 chr3:161008025 T/A cg03342759 chr3:160939853 NMD3 -0.52 -8.77 -0.43 9.03e-17 Morning vs. evening chronotype; LUSC cis rs1113500 0.614 rs1343192 chr1:108613888 C/T cg06207961 chr1:108661230 NA 0.35 5.67 0.3 3.09e-8 Growth-regulated protein alpha levels; LUSC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg14582100 chr15:45693742 SPATA5L1 0.58 10.74 0.51 2.64e-23 Homoarginine levels; LUSC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg09267113 chr7:98030324 BAIAP2L1 0.39 5.68 0.3 3.01e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7481584 0.624 rs12417389 chr11:3035304 G/C cg25174290 chr11:3078921 CARS -0.4 -5.99 -0.31 5.57e-9 Calcium levels; LUSC cis rs34779708 0.966 rs34630580 chr10:35449228 A/G cg03585969 chr10:35415529 CREM 0.62 9.05 0.44 1.16e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs17607347 0.542 rs17677890 chr16:72557243 T/A cg12945194 chr11:64703312 GPHA2 0.38 6.06 0.31 3.74e-9 Intelligence (multi-trait analysis); LUSC cis rs7223966 1.000 rs16947005 chr17:61702989 C/T cg00945038 chr17:61921165 SMARCD2 -0.38 -5.72 -0.3 2.35e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9581857 0.547 rs9581881 chr13:28106637 A/G cg22138327 chr13:27999177 GTF3A 0.64 7.15 0.36 5.37e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs10435719 0.834 rs11250176 chr8:11792816 A/G cg21775007 chr8:11205619 TDH 0.47 6.67 0.34 1.09e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14993530 chr1:245027115 HNRNPU -0.41 -6.12 -0.32 2.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3771570 0.892 rs55751610 chr2:242346057 C/T cg21155796 chr2:242212141 HDLBP 0.61 6.76 0.35 6.18e-11 Prostate cancer; LUSC cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.82 0.68 1.93e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.85 0.66 1.36e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9888739 0.841 rs11864503 chr16:31331137 T/C cg15817542 chr16:31343056 ITGAM -0.51 -6.18 -0.32 1.82e-9 Systemic lupus erythematosus; LUSC cis rs381815 0.821 rs416258 chr11:16911636 G/C cg05701403 chr11:16947551 PLEKHA7 0.36 5.65 0.3 3.42e-8 Diastolic blood pressure;Systolic blood pressure;Blood pressure; LUSC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.37 -6.4 -0.33 5.39e-10 High light scatter reticulocyte count; LUSC cis rs6430585 0.528 rs3112496 chr2:136711064 C/T cg07169764 chr2:136633963 MCM6 1.01 15.33 0.64 1.5e-40 Corneal structure; LUSC cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg02175503 chr12:58329896 NA 0.61 9.99 0.48 9.8e-21 Intelligence (multi-trait analysis); LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg22638593 chr5:131593259 PDLIM4 0.42 6.18 0.32 1.89e-9 Acylcarnitine levels; LUSC cis rs709400 0.663 rs11623869 chr14:103883633 G/T cg24130564 chr14:104152367 KLC1 -0.44 -6.22 -0.32 1.49e-9 Body mass index; LUSC cis rs7100689 0.646 rs7089003 chr10:82124155 T/C cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs477692 0.870 rs512655 chr10:131424547 T/A cg05714579 chr10:131428358 MGMT 0.52 7.98 0.4 2.44e-14 Response to temozolomide; LUSC cis rs1045714 0.895 rs4721866 chr7:2643341 G/A cg24848437 chr7:2645542 IQCE 0.62 6.93 0.35 2.13e-11 Urate levels in lean individuals; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07138452 chr17:17141020 FLCN 0.45 7.21 0.37 3.82e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs11165623 0.564 rs6669908 chr1:96998261 G/A cg10631902 chr5:14652156 NA -0.41 -6.06 -0.31 3.69e-9 Hip circumference;Waist circumference; LUSC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg03929089 chr4:120376271 NA -1.03 -20.12 -0.74 1.48e-59 Height; LUSC cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg18252515 chr7:66147081 NA 0.53 7.17 0.37 4.9e-12 Corneal structure; LUSC cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg06784218 chr1:46089804 CCDC17 0.48 9.63 0.47 1.62e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg08677398 chr8:58056175 NA 0.52 6.98 0.36 1.59e-11 Developmental language disorder (linguistic errors); LUSC cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.95 0.36 1.96e-11 Rheumatoid arthritis; LUSC cis rs1153858 1.000 rs1618874 chr15:45622786 A/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.18 0.49 2.21e-21 Homoarginine levels; LUSC cis rs73206853 0.764 rs61117387 chr12:110867725 C/A cg12870014 chr12:110450643 ANKRD13A 0.67 7.16 0.36 5.29e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.27 0.59 1.5e-32 Total body bone mineral density; LUSC trans rs7726839 0.507 rs111707179 chr5:593308 T/A cg25482853 chr8:67687455 SGK3 1.15 16.64 0.67 1.03e-45 Obesity-related traits; LUSC cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.54 -0.34 2.34e-10 Schizophrenia; LUSC trans rs4693167 0.927 rs6837088 chr4:88400924 A/C cg20462512 chr12:5543155 NTF3 0.33 6.22 0.32 1.46e-9 Blood protein levels; LUSC cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.51 -0.46 4.02e-19 Chronic sinus infection; LUSC cis rs2303759 0.670 rs45549132 chr19:49794028 G/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.31 0.33 9.02e-10 Multiple sclerosis; LUSC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg12560992 chr17:57184187 TRIM37 -0.9 -17.69 -0.7 6.85e-50 Intelligence (multi-trait analysis); LUSC cis rs12973672 0.812 rs28365133 chr19:35761519 A/G cg12095397 chr19:35769544 USF2 0.44 6.67 0.34 1.09e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1668873 0.562 rs10157145 chr1:205261963 T/C cg21643547 chr1:205240462 TMCC2 0.31 5.89 0.31 9.34e-9 Mean platelet volume; LUSC cis rs11190604 0.767 rs79106148 chr10:102184732 G/A cg07080220 chr10:102295463 HIF1AN 0.59 7.86 0.4 5.23e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs61931739 0.500 rs11053222 chr12:34481100 C/A cg06521331 chr12:34319734 NA -0.41 -6.43 -0.33 4.4e-10 Morning vs. evening chronotype; LUSC cis rs10752881 1.000 rs6658501 chr1:182991417 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.67 -10.35 -0.49 5.75e-22 Colorectal cancer; LUSC cis rs7255045 0.788 rs8111370 chr19:12948864 G/T cg21491176 chr19:12958399 MAST1 -0.33 -5.8 -0.3 1.55e-8 Mean corpuscular volume; LUSC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg02569458 chr12:86230093 RASSF9 0.58 9.78 0.47 4.91e-20 Major depressive disorder; LUSC cis rs12493885 0.725 rs11718646 chr3:153741996 C/T cg17054900 chr3:154042577 DHX36 -0.7 -7.37 -0.37 1.33e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs10256972 0.681 rs12702016 chr7:1129392 C/T cg13565492 chr6:43139072 SRF -0.41 -6.04 -0.31 4.04e-9 Longevity;Endometriosis; LUSC trans rs62056376 0.646 rs2857657 chr17:32583132 G/C cg19986872 chr5:131347773 ACSL6 -0.38 -5.98 -0.31 5.72e-9 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg16339924 chr4:17578868 LAP3 0.53 8.07 0.4 1.31e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg05868516 chr6:26286170 HIST1H4H 0.36 6.0 0.31 5.18e-9 Educational attainment; LUSC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.64 -0.34 1.26e-10 Alzheimer's disease (late onset); LUSC cis rs1790761 0.692 rs10444362 chr11:67333090 G/A cg00864171 chr11:67383662 NA 0.34 5.91 0.31 8.43e-9 Mean corpuscular volume; LUSC cis rs73206853 0.563 rs9706438 chr12:111195158 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 6.91 0.35 2.49e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg09034736 chr1:150693464 HORMAD1 0.45 6.13 0.32 2.53e-9 Melanoma; LUSC cis rs7589342 0.628 rs12996286 chr2:106399667 A/G cg14210321 chr2:106509881 NCK2 -0.45 -5.66 -0.3 3.24e-8 Addiction; LUSC cis rs11906854 0.501 rs7265718 chr20:34635441 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.1 -0.32 2.87e-9 Migraine - clinic-based; LUSC cis rs7267979 1.000 rs6083804 chr20:25317060 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.57 -0.75 2.54e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg25554036 chr4:6271136 WFS1 0.61 12.27 0.56 7.88e-29 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg27068330 chr11:65405492 SIPA1 0.56 6.53 0.34 2.51e-10 Blood pressure (age interaction); LUSC cis rs2544523 0.511 rs10929387 chr2:15912926 A/G cg26669897 chr2:15909070 NA 0.3 6.21 0.32 1.58e-9 Asthma or chronic obstructive pulmonary disease; LUSC cis rs17604090 0.818 rs73090342 chr7:29687540 T/C cg19413766 chr7:29689036 LOC646762 -0.63 -7.43 -0.38 8.91e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs10892173 0.566 rs12364667 chr11:117675286 A/C cg04064380 chr11:117688259 NA -0.44 -5.69 -0.3 2.82e-8 Myopia; LUSC cis rs7267979 1.000 rs2500404 chr20:25359758 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.57 -0.69 2.11e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.38 7.47 0.38 7.28e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6952808 0.600 rs2895202 chr7:2131829 T/C cg04565464 chr8:145669602 NFKBIL2 0.38 6.15 0.32 2.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg10253484 chr15:75165896 SCAMP2 -0.46 -6.55 -0.34 2.11e-10 Breast cancer; LUSC cis rs10072221 0.836 rs7707426 chr5:75707371 C/G cg03132911 chr5:75698732 IQGAP2 0.36 6.07 0.32 3.44e-9 Mean platelet volume; LUSC cis rs73001065 0.901 rs73004926 chr19:19671266 C/T cg03709012 chr19:19516395 GATAD2A 0.88 6.92 0.35 2.27e-11 LDL cholesterol; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.17e-9 Prudent dietary pattern; LUSC cis rs11122272 0.525 rs2739517 chr1:231537914 C/A cg06096015 chr1:231504339 EGLN1 0.54 9.51 0.46 3.95e-19 Hemoglobin concentration; LUSC trans rs11949289 1.000 rs12188000 chr5:28349377 A/G cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.56e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11122272 0.735 rs2491403 chr1:231511185 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg18681998 chr4:17616180 MED28 0.86 15.49 0.65 3.49e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg10053473 chr17:62856997 LRRC37A3 0.65 10.33 0.49 6.89e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg24692254 chr21:30365293 RNF160 -0.82 -15.1 -0.64 1.19e-39 Dental caries; LUSC cis rs4664304 0.903 rs72957576 chr2:160754132 A/C cg23995753 chr2:160760732 LY75 -0.31 -5.75 -0.3 2.05e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs17826219 0.706 rs57698184 chr17:29064918 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.04e-11 Body mass index; LUSC cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg03676636 chr4:99064102 C4orf37 0.36 8.04 0.4 1.59e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg07157834 chr1:205819609 PM20D1 0.89 16.49 0.67 4.19e-45 Menarche (age at onset); LUSC trans rs11949289 0.935 rs1035886 chr5:28336609 T/C cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.44e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg13683864 chr3:40499215 RPL14 -0.97 -17.11 -0.68 1.49e-47 Renal cell carcinoma; LUSC cis rs3857536 0.740 rs6455080 chr6:66887413 T/A cg07460842 chr6:66804631 NA -0.46 -6.47 -0.33 3.5e-10 Blood trace element (Cu levels); LUSC cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11671005 0.616 rs12980907 chr19:58956326 C/T cg13877915 chr19:58951672 ZNF132 0.45 5.78 0.3 1.71e-8 Mean platelet volume; LUSC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs6942756 0.806 rs10257620 chr7:128901429 C/A cg02491457 chr7:128862824 NA 0.51 7.74 0.39 1.18e-13 White matter hyperintensity burden; LUSC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg11764359 chr7:65958608 NA -0.7 -10.8 -0.51 1.57e-23 Aortic root size; LUSC cis rs713587 0.571 rs2918630 chr2:25314186 A/G cg01884057 chr2:25150051 NA -0.27 -5.78 -0.3 1.74e-8 Body mass index in non-asthmatics; LUSC cis rs35995292 0.500 rs2392606 chr7:38926955 C/A cg19327137 chr7:38886074 VPS41 0.55 10.25 0.49 1.33e-21 Subjective well-being (multi-trait analysis); LUSC cis rs7937682 0.632 rs57414412 chr11:111769431 G/A cg09085632 chr11:111637200 PPP2R1B 0.93 12.47 0.56 1.45e-29 Primary sclerosing cholangitis; LUSC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg23262073 chr20:60523788 NA -0.43 -6.16 -0.32 2.09e-9 Body mass index; LUSC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg12863693 chr15:85201151 NMB 0.36 7.38 0.37 1.25e-12 Schizophrenia; LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.86 0.31 1.11e-8 Menopause (age at onset); LUSC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg11494091 chr17:61959527 GH2 0.39 6.77 0.35 5.68e-11 Height; LUSC cis rs868036 0.718 rs4776984 chr15:68118194 A/C cg05925327 chr15:68127851 NA -0.37 -5.9 -0.31 8.83e-9 Restless legs syndrome; LUSC cis rs3755132 0.929 rs3770463 chr2:15749658 T/C cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.61e-12 Wilms tumor; LUSC cis rs9865818 0.791 rs56046601 chr3:188108642 G/C cg23651889 chr3:188115336 LPP 0.39 5.91 0.31 8.33e-9 Allergic sensitization; LUSC cis rs17401966 0.931 rs34225619 chr1:10371987 C/T cg19773385 chr1:10388646 KIF1B -0.55 -8.49 -0.42 6.95e-16 Hepatocellular carcinoma; LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.96 0.51 4.51e-24 Menopause (age at onset); LUSC cis rs7560272 0.695 rs780394 chr2:73700930 A/G cg20560298 chr2:73613845 ALMS1 0.46 7.19 0.37 4.24e-12 Schizophrenia; LUSC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.36 0.33 6.81e-10 Hip circumference adjusted for BMI; LUSC cis rs2742417 1.000 rs2742373 chr3:45784046 C/G cg09608765 chr3:45636137 LIMD1 -0.36 -7.17 -0.37 4.98e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11098499 0.863 rs11933966 chr4:120476715 G/A cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg21644426 chr2:191273491 MFSD6 -0.6 -9.54 -0.46 3.16e-19 Pulse pressure; LUSC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg17376030 chr22:41985996 PMM1 -0.47 -6.03 -0.31 4.35e-9 Vitiligo; LUSC trans rs8072100 0.790 rs6505048 chr17:45674998 G/A cg04995722 chr7:26192034 NFE2L3 0.42 6.59 0.34 1.67e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9837602 1.000 rs10212525 chr3:99713377 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.17 0.32 1.96e-9 Breast cancer; LUSC cis rs1371867 0.846 rs1788182 chr8:101334620 C/T cg06636551 chr8:101224915 SPAG1 -0.38 -7.13 -0.36 6.31e-12 Atrioventricular conduction; LUSC cis rs868036 1.000 rs7168156 chr15:68102933 T/C cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg00701064 chr4:6280414 WFS1 0.61 15.96 0.66 4.98e-43 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.53 10.02 0.48 8.1e-21 Bipolar disorder; LUSC cis rs9311676 0.656 rs11918201 chr3:58387777 C/T cg13750441 chr3:58318267 PXK 0.35 6.72 0.35 7.86e-11 Systemic lupus erythematosus; LUSC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg16680214 chr1:154839983 KCNN3 -0.52 -9.76 -0.47 5.77e-20 Prostate cancer; LUSC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg06481639 chr22:41940642 POLR3H -0.52 -5.9 -0.31 8.99e-9 Vitiligo; LUSC cis rs7582720 1.000 rs72934765 chr2:203758551 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.67 0.43 1.95e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9649465 0.561 rs2429621 chr7:123430316 A/G cg03229431 chr7:123269106 ASB15 0.48 7.68 0.39 1.76e-13 Migraine; LUSC cis rs12973672 0.812 rs35497966 chr19:35764965 A/C cg12095397 chr19:35769544 USF2 0.45 6.83 0.35 3.93e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg05623727 chr3:50126028 RBM5 -0.31 -5.83 -0.3 1.31e-8 Intelligence (multi-trait analysis); LUSC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg24838063 chr12:130822603 PIWIL1 0.69 10.71 0.51 3.44e-23 Menopause (age at onset); LUSC cis rs9796 0.621 rs7170049 chr15:41484287 C/A cg18705301 chr15:41695430 NDUFAF1 -0.52 -9.07 -0.44 1.05e-17 Menopause (age at onset); LUSC cis rs68170813 0.617 rs7797791 chr7:107197222 T/C cg02696742 chr7:106810147 HBP1 -0.64 -8.34 -0.42 1.92e-15 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11328403 chr17:16120890 PIGL -0.48 -6.15 -0.32 2.27e-9 Bipolar disorder and schizophrenia; LUSC trans rs724744 0.680 rs1318601 chr6:22357345 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.06 -0.31 3.61e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg07701084 chr6:150067640 NUP43 0.57 8.74 0.43 1.18e-16 Lung cancer; LUSC cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg05347473 chr6:146136440 FBXO30 0.53 8.91 0.44 3.27e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg12463550 chr7:65579703 CRCP 0.52 7.61 0.38 2.87e-13 Aortic root size; LUSC cis rs10791323 0.569 rs1944734 chr11:133720077 G/A cg00579200 chr11:133705235 NA -0.43 -6.4 -0.33 5.35e-10 Childhood ear infection; LUSC cis rs9677476 1.000 rs7584535 chr2:232106857 C/T cg07929768 chr2:232055508 NA 0.31 5.9 0.31 8.8e-9 Food antigen IgG levels; LUSC cis rs2290159 0.948 rs73130305 chr3:12621075 C/T cg23032965 chr3:12705835 RAF1 0.57 7.08 0.36 8.42e-12 Cholesterol, total; LUSC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg13939156 chr17:80058883 NA -0.33 -6.42 -0.33 4.68e-10 Blood metabolite levels; LUSC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg13393036 chr8:95962371 TP53INP1 0.32 6.38 0.33 5.94e-10 Type 2 diabetes; LUSC trans rs853679 0.607 rs13199906 chr6:27834139 C/G cg06606381 chr12:133084897 FBRSL1 -1.02 -9.08 -0.44 9.93e-18 Depression; LUSC cis rs9807989 0.501 rs11903946 chr2:103005330 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.29e-12 Asthma; LUSC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg09359103 chr1:154839909 KCNN3 -0.71 -16.54 -0.67 2.59e-45 Prostate cancer; LUSC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg09359103 chr1:154839909 KCNN3 -0.69 -15.95 -0.66 5.7e-43 Prostate cancer; LUSC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.6 0.46 2.01e-19 Mean platelet volume; LUSC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg03806693 chr22:41940476 POLR3H 0.99 13.72 0.6 2.7200000000000002e-34 Cannabis dependence symptom count; LUSC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg02038168 chr22:39784481 NA -0.48 -7.72 -0.39 1.35e-13 Intelligence (multi-trait analysis); LUSC cis rs12421382 0.614 rs12799395 chr11:109390862 G/T cg11473876 chr11:109292803 C11orf87 0.34 5.74 0.3 2.15e-8 Schizophrenia; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg23978390 chr7:1156363 C7orf50 0.52 7.41 0.38 1.01e-12 Longevity;Endometriosis; LUSC cis rs478304 0.651 rs12225620 chr11:65505448 T/C cg10518572 chr11:65560635 OVOL1 -0.26 -6.01 -0.31 4.88e-9 Acne (severe); LUSC cis rs12956009 0.518 rs71352652 chr18:44869536 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.41 0.33 5.01e-10 Educational attainment (years of education); LUSC cis rs61612642 0.537 rs73434275 chr6:42156239 G/A cg01092361 chr6:42185687 MRPS10 0.79 8.17 0.41 6.55e-15 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs968451 0.789 rs1569501 chr22:39683534 A/T cg17798944 chr22:39715225 SNORD43;RPL3 0.7 10.16 0.49 2.58e-21 Primary biliary cholangitis; LUSC cis rs1448094 1.000 rs7305284 chr12:86343786 C/T cg00310523 chr12:86230176 RASSF9 0.38 6.99 0.36 1.49e-11 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11141497 chr11:6633666 TAF10 -0.43 -6.33 -0.33 8.01e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17095355 1.000 rs17126886 chr10:111695257 G/C cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.96 -0.36 1.81e-11 Biliary atresia; LUSC cis rs9463078 0.764 rs3846896 chr6:44834094 G/A cg25276700 chr6:44698697 NA -0.28 -5.67 -0.3 3.09e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.31 0.33 8.63e-10 Personality dimensions; LUSC trans rs4714291 0.963 rs1923466 chr6:39965946 A/C cg02267698 chr19:7991119 CTXN1 0.49 6.84 0.35 3.9e-11 Strep throat; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07545948 chr6:12012569 HIVEP1 0.4 6.36 0.33 6.76e-10 Asthma; LUSC cis rs3772130 0.962 rs35679661 chr3:121484763 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.68 9.77 0.47 5.21e-20 Cognitive performance; LUSC cis rs35146811 0.735 rs11764176 chr7:99786964 G/T cg22906224 chr7:99728672 NA 0.47 6.54 0.34 2.36e-10 Coronary artery disease; LUSC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC cis rs12190007 0.512 rs2984464 chr6:169837242 T/C cg15038512 chr6:170123185 PHF10 -0.38 -6.24 -0.32 1.33e-9 Obesity-related traits; LUSC cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -9.85 -0.47 2.9e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg00074818 chr8:8560427 CLDN23 0.57 9.76 0.47 5.63e-20 Obesity-related traits; LUSC trans rs9747201 0.894 rs4503854 chr17:80178696 A/T cg07393940 chr7:158741817 NA 0.53 8.22 0.41 4.42e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2050392 0.792 rs303434 chr10:30714440 G/A cg18806716 chr10:30721971 MAP3K8 -0.47 -7.7 -0.39 1.54e-13 Inflammatory bowel disease; LUSC cis rs11971779 0.648 rs7799165 chr7:139084957 G/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg00631329 chr6:26305371 NA -0.34 -5.98 -0.31 5.89e-9 Intelligence (multi-trait analysis); LUSC cis rs208520 0.690 rs1100981 chr6:66852052 T/C cg07460842 chr6:66804631 NA -1.13 -17.76 -0.7 3.58e-50 Exhaled nitric oxide output; LUSC trans rs7829975 0.688 rs13270194 chr8:8378102 T/C cg21775007 chr8:11205619 TDH 0.44 6.57 0.34 1.95e-10 Mood instability; LUSC cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs754133 0.964 rs4759318 chr12:54420098 C/T cg10005224 chr12:54424964 HOXC4;HOXC5 0.42 8.39 0.42 1.4e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg03146154 chr1:46216737 IPP 0.51 7.48 0.38 6.55e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11252926 0.625 rs7903876 chr10:482678 T/C cg05528280 chr10:464225 DIP2C -0.4 -6.17 -0.32 1.99e-9 Psychosis in Alzheimer's disease; LUSC trans rs57046232 0.552 rs6085497 chr20:6315937 A/G cg21095983 chr6:86352623 SYNCRIP 0.52 7.78 0.39 9.2e-14 Colorectal cancer; LUSC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12368653 0.607 rs7966795 chr12:58031413 C/A cg12615879 chr12:58013172 SLC26A10 0.41 9.61 0.47 1.82e-19 Multiple sclerosis; LUSC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg24562669 chr7:97807699 LMTK2 0.33 5.81 0.3 1.42e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs6138458 1.000 rs227624 chr20:24911562 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.1 0.7 1.58e-51 Blood protein levels; LUSC cis rs7188861 0.592 rs1794022 chr16:11376446 A/G cg00044050 chr16:11439710 C16orf75 0.47 5.71 0.3 2.46e-8 HDL cholesterol; LUSC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg16339924 chr4:17578868 LAP3 -0.59 -8.71 -0.43 1.44e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg03929089 chr4:120376271 NA -0.79 -12.83 -0.57 6.65e-31 Height; LUSC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.71 -0.39 1.45e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs4073582 0.595 rs9326370 chr11:65992008 A/G cg14036092 chr11:66035641 RAB1B 0.41 5.94 0.31 7.3e-9 Gout; LUSC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg20295408 chr7:1910781 MAD1L1 -0.45 -6.43 -0.33 4.31e-10 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg13319975 chr6:146136371 FBXO30 -0.72 -11.46 -0.53 7.1e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs701145 0.585 rs1612933 chr3:153786119 G/A cg17054900 chr3:154042577 DHX36 -0.55 -5.92 -0.31 8.07e-9 Coronary artery disease; LUSC cis rs2303282 0.664 rs2587867 chr16:56404011 C/T cg00500540 chr16:56394104 NA -0.4 -6.86 -0.35 3.34e-11 Breast cancer; LUSC cis rs6964587 1.000 rs36120033 chr7:91679298 G/A cg17063962 chr7:91808500 NA 0.58 9.24 0.45 2.94e-18 Breast cancer; LUSC cis rs7940866 0.803 rs1865296 chr11:130882944 C/T cg12179176 chr11:130786555 SNX19 -0.64 -9.89 -0.48 2.07e-20 Schizophrenia; LUSC trans rs11098499 0.954 rs35091806 chr4:120325529 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg02269571 chr22:50332266 NA 0.59 8.76 0.43 9.92e-17 Schizophrenia; LUSC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -6.76 -0.35 6.15e-11 Developmental language disorder (linguistic errors); LUSC cis rs35883536 0.647 rs17402630 chr1:101046587 C/T cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC cis rs7927592 0.513 rs556442 chr11:68192690 G/A cg01657329 chr11:68192670 LRP5 0.51 7.98 0.4 2.34e-14 Total body bone mineral density; LUSC cis rs7072216 0.763 rs6584202 chr10:100170383 G/A cg26618903 chr10:100175079 PYROXD2 -0.45 -8.57 -0.42 3.77e-16 Metabolite levels; LUSC cis rs17621444 0.522 rs4536126 chr10:121809519 T/C cg02041677 chr10:121771263 NA -0.34 -6.31 -0.33 8.87e-10 IgG glycosylation; LUSC cis rs7508679 1.000 rs7508679 chr19:7222832 A/G cg09779027 chr19:7224513 INSR 0.43 9.45 0.46 6.06e-19 Hypothyroidism; LUSC cis rs467650 0.549 rs720859 chr5:97995417 A/G cg03885343 chr5:98108198 RGMB 0.32 5.77 0.3 1.83e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC trans rs7824557 0.606 rs2736273 chr8:11199938 C/A cg15556689 chr8:8085844 FLJ10661 0.54 8.0 0.4 2.11e-14 Retinal vascular caliber; LUSC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg12927641 chr6:109611667 NA -0.37 -6.35 -0.33 6.85e-10 Reticulocyte fraction of red cells; LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11644478 chr21:40555479 PSMG1 0.95 19.19 0.72 7.57e-56 Cognitive function; LUSC cis rs6076065 0.723 rs6076073 chr20:23414489 G/A cg11657817 chr20:23433608 CST11 0.41 7.29 0.37 2.24e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs8018808 0.935 rs11627385 chr14:77936343 T/C cg20045696 chr14:77926864 AHSA1 0.34 5.8 0.3 1.56e-8 Myeloid white cell count; LUSC cis rs1670533 0.932 rs13140571 chr4:1054358 T/C cg27284194 chr4:1044797 NA 0.6 8.96 0.44 2.34e-17 Recombination rate (females); LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.18 0.64 6.19e-40 Platelet count; LUSC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg11584989 chr19:19387371 SF4 0.51 6.49 0.33 3.1e-10 Bipolar disorder; LUSC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17246714 chr3:55519186 WNT5A 0.42 6.24 0.32 1.3e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20110633 chr19:44302906 LYPD5 -0.5 -6.81 -0.35 4.43e-11 Bipolar disorder and schizophrenia; LUSC cis rs9549260 0.755 rs7988604 chr13:41215802 G/T cg21288729 chr13:41239152 FOXO1 0.64 9.9 0.48 2.01e-20 Red blood cell count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17510133 chr11:17298268 NUCB2 -0.43 -6.32 -0.33 8.38e-10 Electrocardiographic conduction measures; LUSC cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg17063962 chr7:91808500 NA -0.61 -9.58 -0.46 2.24e-19 Breast cancer; LUSC cis rs7149337 0.836 rs34953083 chr14:51672432 A/G cg23942311 chr14:51606299 NA 0.48 10.42 0.5 3.29e-22 Cancer; LUSC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg24881330 chr22:46731750 TRMU 0.91 7.03 0.36 1.15e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs113835537 0.529 rs3816492 chr11:66297363 C/T cg24851651 chr11:66362959 CCS 0.53 7.56 0.38 3.95e-13 Airway imaging phenotypes; LUSC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg15316289 chr22:50310904 ALG12;CRELD2 0.39 5.74 0.3 2.13e-8 Schizophrenia; LUSC trans rs208520 0.690 rs3843513 chr6:66836797 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -16.94 -0.68 6.71e-47 Exhaled nitric oxide output; LUSC cis rs17253792 0.822 rs12323476 chr14:56172722 C/T cg01858014 chr14:56050164 KTN1 0.68 6.27 0.32 1.13e-9 Putamen volume; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs28785552 0.769 rs28796114 chr19:53234319 T/C cg22067481 chr19:53234126 ZNF611 -0.47 -6.37 -0.33 6.13e-10 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs2273669 0.667 rs12205053 chr6:109338110 T/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 8.89e-9 Prostate cancer; LUSC cis rs11585357 0.895 rs72633803 chr1:17616758 G/A cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg13662262 chr21:30364895 RNF160 -0.35 -6.2 -0.32 1.64e-9 Breast cancer; LUSC cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg24562669 chr7:97807699 LMTK2 0.49 8.83 0.44 5.97e-17 Breast cancer; LUSC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg03676636 chr4:99064102 C4orf37 0.36 8.12 0.41 9.4e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs939658 0.776 rs4778925 chr15:79443791 C/T cg17916960 chr15:79447300 NA -0.54 -10.78 -0.51 1.93e-23 Refractive error; LUSC cis rs6580649 0.941 rs4760614 chr12:48427884 A/G cg24011408 chr12:48396354 COL2A1 -0.46 -6.22 -0.32 1.53e-9 Lung cancer; LUSC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg26335602 chr6:28129616 ZNF389 0.46 6.3 0.33 9.49e-10 Parkinson's disease; LUSC cis rs7633770 0.664 rs7373994 chr3:46701114 C/G cg11219411 chr3:46661640 NA -0.35 -6.92 -0.35 2.39e-11 Coronary artery disease; LUSC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.01 -0.36 1.35e-11 Major depressive disorder; LUSC cis rs1348850 0.958 rs12471741 chr2:178448196 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 6.58 0.34 1.87e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13315871 0.929 rs11717783 chr3:58267642 A/T cg20936604 chr3:58311152 NA -0.75 -6.97 -0.36 1.7e-11 Cholesterol, total; LUSC cis rs4363385 0.588 rs7540609 chr1:153024589 C/A cg00922841 chr1:152955080 SPRR1A -0.36 -5.97 -0.31 6.18e-9 Inflammatory skin disease; LUSC cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg11584989 chr19:19387371 SF4 0.58 7.02 0.36 1.22e-11 Bipolar disorder; LUSC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.78 -12.97 -0.58 1.91e-31 Platelet count; LUSC cis rs9815354 0.812 rs7629767 chr3:42043509 T/G cg03022575 chr3:42003672 ULK4 0.6 6.43 0.33 4.44e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg00149659 chr3:10157352 C3orf10 0.98 14.25 0.61 2.48e-36 Alzheimer's disease; LUSC trans rs6076960 0.684 rs6054058 chr20:6262187 T/C cg21095983 chr6:86352623 SYNCRIP 0.53 8.31 0.41 2.42e-15 Smooth-surface caries; LUSC cis rs9611565 0.568 rs5758441 chr22:42132888 C/A cg03806693 chr22:41940476 POLR3H 0.85 12.22 0.56 1.25e-28 Vitiligo; LUSC cis rs9325144 0.560 rs12424821 chr12:38649951 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.28 -0.49 1.02e-21 Morning vs. evening chronotype; LUSC cis rs936229 0.798 rs1869959 chr15:75147332 A/C cg14664628 chr15:75095509 CSK -0.89 -13.67 -0.6 4.14e-34 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9287719 0.967 rs728282 chr2:10750303 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg15556689 chr8:8085844 FLJ10661 0.71 12.21 0.56 1.36e-28 Mood instability; LUSC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs6696846 0.703 rs112653854 chr1:205079251 G/T cg00857998 chr1:205179979 DSTYK 0.64 10.03 0.48 7.3e-21 Red blood cell count; LUSC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg24399712 chr22:39784796 NA -0.61 -10.22 -0.49 1.59e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9788682 0.747 rs938682 chr15:78896547 A/G cg24631222 chr15:78858424 CHRNA5 0.68 9.53 0.46 3.45e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg14993813 chr1:46806288 NSUN4 -0.52 -7.29 -0.37 2.2e-12 Menopause (age at onset); LUSC trans rs57046232 0.511 rs6054143 chr20:6334697 C/T cg17788362 chr6:86352627 SYNCRIP 0.42 5.96 0.31 6.34e-9 Colorectal cancer; LUSC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg07936489 chr17:37558343 FBXL20 -0.7 -9.55 -0.46 2.85e-19 Glomerular filtration rate (creatinine); LUSC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs12908161 0.959 rs3748376 chr15:85328352 C/T cg17507749 chr15:85114479 UBE2QP1 0.52 6.41 0.33 5.1e-10 Schizophrenia; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg11843238 chr5:131593191 PDLIM4 0.33 6.0 0.31 5.02e-9 Blood metabolite levels; LUSC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg03609598 chr5:56110824 MAP3K1 -0.43 -6.3 -0.33 9.31e-10 Initial pursuit acceleration; LUSC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.64 0.47 1.49e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11792861 0.781 rs2297581 chr9:111755008 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.18 0.41 5.87e-15 Menarche (age at onset); LUSC cis rs7255 0.545 rs9306895 chr2:20878153 T/C cg05481257 chr2:20870211 GDF7 -0.33 -5.77 -0.3 1.85e-8 Barrett's esophagus or Esophageal adenocarcinoma;Esophageal adenocarcinoma; LUSC cis rs17661538 0.504 rs71491145 chr10:18460336 G/A cg03634479 chr10:18430412 CACNB2 0.65 5.95 0.31 6.89e-9 Response to antipsychotic treatment; LUSC cis rs3106136 0.527 rs2632410 chr4:95149507 A/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.41 -0.42 1.2e-15 Capecitabine sensitivity; LUSC cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg07148914 chr20:33460835 GGT7 0.54 8.4 0.42 1.33e-15 Height; LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.26e-25 Gut microbiome composition (summer); LUSC trans rs1941687 0.527 rs1493914 chr18:31362327 C/T cg27147174 chr7:100797783 AP1S1 -0.63 -10.12 -0.48 3.7e-21 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1997103 0.954 rs56030000 chr7:55405750 A/G cg17469321 chr7:55412551 NA 0.66 10.62 0.5 6.87e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05115182 chr10:99496889 ZFYVE27 -0.51 -6.23 -0.32 1.38e-9 Bipolar disorder and schizophrenia; LUSC cis rs1670533 1.000 rs13119276 chr4:1051574 T/C cg16405210 chr4:1374714 KIAA1530 -0.46 -5.71 -0.3 2.44e-8 Recombination rate (females); LUSC cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.35e-22 Alzheimer's disease (late onset); LUSC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs34779708 0.931 rs2384289 chr10:35343525 G/A cg03585969 chr10:35415529 CREM 0.6 8.74 0.43 1.15e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9788682 0.624 rs518425 chr15:78883813 A/G cg24631222 chr15:78858424 CHRNA5 0.62 9.39 0.46 9.38e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs910316 0.726 rs12882664 chr14:75446778 C/T cg08847533 chr14:75593920 NEK9 0.83 14.19 0.61 4.34e-36 Height; LUSC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg17279839 chr7:150038598 RARRES2 0.43 6.58 0.34 1.81e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg06641503 chr3:48959341 ARIH2 -0.39 -5.97 -0.31 6.03e-9 Parkinson's disease; LUSC cis rs68170813 0.559 rs12537785 chr7:107050221 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.14 -0.45 6.29e-18 Coronary artery disease; LUSC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg08270630 chr22:50330655 NA -0.46 -6.92 -0.35 2.31e-11 Schizophrenia; LUSC cis rs10755723 1 rs10755723 chr6:42593718 T/A cg10605015 chr6:42532144 UBR2 0.48 5.65 0.3 3.41e-8 Lung cancer in never smokers; LUSC cis rs7177699 0.557 rs12898292 chr15:79112603 A/G cg00540400 chr15:79124168 NA 0.45 7.57 0.38 3.63e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg24209194 chr3:40518798 ZNF619 -0.52 -7.4 -0.38 1.08e-12 Renal cell carcinoma; LUSC cis rs7833986 0.501 rs2719259 chr8:56941630 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.72 11.87 0.54 2.28e-27 Height; LUSC cis rs11155671 0.530 rs4458704 chr6:150232879 A/C cg07701084 chr6:150067640 NUP43 0.45 6.6 0.34 1.62e-10 Testicular germ cell tumor; LUSC cis rs2708377 0.929 rs4763634 chr12:11307615 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs10927875 0.596 rs1806990 chr1:16129377 G/A cg21385522 chr1:16154831 NA -0.98 -18.46 -0.71 6.21e-53 Dilated cardiomyopathy; LUSC cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg17420585 chr12:42539391 GXYLT1 -0.38 -7.58 -0.38 3.46e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg26769984 chr7:1090371 C7orf50 0.56 8.79 0.43 7.82e-17 Bronchopulmonary dysplasia; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg00166722 chr3:10149974 C3orf24 0.54 7.5 0.38 5.85e-13 Alzheimer's disease; LUSC cis rs72634258 0.503 rs697674 chr1:7837878 C/G cg26816564 chr1:7831052 VAMP3 0.97 13.99 0.61 2.47e-35 Inflammatory bowel disease; LUSC cis rs7119 0.717 rs12902912 chr15:77809170 A/G cg27398640 chr15:77910606 LINGO1 -0.3 -6.39 -0.33 5.43e-10 Type 2 diabetes; LUSC cis rs2486288 0.656 rs11632752 chr15:45551140 A/G cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.8 -0.51 1.62e-23 Glomerular filtration rate; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg13453750 chr1:205783389 SLC41A1 -0.32 -6.26 -0.32 1.18e-9 Menarche (age at onset); LUSC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg14416269 chr4:6271139 WFS1 0.53 11.32 0.53 2.23e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs9329221 0.905 rs17765901 chr8:10249480 G/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.33 -0.41 2.09e-15 Neuroticism; LUSC cis rs3126085 0.877 rs57597406 chr1:152246619 C/G cg26876637 chr1:152193138 HRNR 0.45 6.04 0.31 4.13e-9 Atopic dermatitis; LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg23788917 chr6:8435910 SLC35B3 -0.5 -7.42 -0.38 9.8e-13 Motion sickness; LUSC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2204008 0.837 rs11168387 chr12:37962818 G/A cg26384229 chr12:38710491 ALG10B -0.81 -13.41 -0.59 4.05e-33 Bladder cancer; LUSC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg00074818 chr8:8560427 CLDN23 0.43 7.07 0.36 9.09e-12 Obesity-related traits; LUSC cis rs3008870 1.000 rs3008888 chr1:67368965 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.35 0.64 1.31e-40 Lymphocyte percentage of white cells; LUSC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg03233332 chr7:66118400 NA 0.42 6.06 0.31 3.61e-9 Aortic root size; LUSC cis rs41271951 0.558 rs79671334 chr1:151115887 C/G cg11822372 chr1:151115635 SEMA6C -0.86 -6.67 -0.34 1.07e-10 Blood protein levels; LUSC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.6 -0.38 3.06e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6496044 0.568 rs6496049 chr15:86069205 C/G cg13263323 chr15:86062960 AKAP13 -0.37 -6.04 -0.31 4.14e-9 Interstitial lung disease; LUSC cis rs1670533 1.000 rs10084888 chr4:1053814 G/T cg02018176 chr4:1364513 KIAA1530 0.43 6.15 0.32 2.24e-9 Recombination rate (females); LUSC cis rs950169 0.580 rs11633762 chr15:85187152 T/C cg12863693 chr15:85201151 NMB 0.38 7.97 0.4 2.47e-14 Schizophrenia; LUSC cis rs9457247 1.000 rs393727 chr6:167398632 T/A cg07741184 chr6:167504864 NA 0.36 6.53 0.34 2.52e-10 Crohn's disease; LUSC cis rs7647973 0.769 rs6446204 chr3:49034879 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.24 0.45 2.88e-18 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18950002 chr17:79673969 MRPL12 0.45 6.4 0.33 5.26e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs8002861 0.664 rs1808097 chr13:44424766 A/G cg12856521 chr11:46389249 DGKZ 0.43 6.44 0.33 4.28e-10 Leprosy; LUSC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg23630131 chr7:65973040 NA 0.21 5.81 0.3 1.45e-8 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26586300 chr17:80416415 NARF -0.4 -6.04 -0.31 4.12e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg18190219 chr22:46762943 CELSR1 -0.62 -6.21 -0.32 1.62e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs61931739 0.534 rs11053131 chr12:34282109 A/G cg26384229 chr12:38710491 ALG10B 0.62 10.08 0.48 4.78e-21 Morning vs. evening chronotype; LUSC cis rs1878931 0.567 rs7196196 chr16:3411855 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 17.03 0.68 2.95e-47 Body mass index (adult); LUSC cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg06092702 chr1:163392909 NA -0.44 -7.41 -0.38 1.02e-12 Motion sickness; LUSC cis rs7258465 1.000 rs271624 chr19:18627953 A/G cg25828334 chr19:18545568 ISYNA1 -0.35 -6.0 -0.31 5.13e-9 Breast cancer; LUSC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg01097406 chr16:89675127 NA -0.36 -7.11 -0.36 7.15e-12 Vitiligo; LUSC cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.99 0.36 1.46e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs6502050 0.805 rs7503095 chr17:80107354 G/A cg07393940 chr7:158741817 NA 0.36 6.52 0.34 2.61e-10 Life satisfaction; LUSC cis rs6430585 0.527 rs2278731 chr2:136396300 T/C cg07169764 chr2:136633963 MCM6 1.06 13.9 0.61 5.76e-35 Corneal structure; LUSC cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg01657329 chr11:68192670 LRP5 -0.44 -6.62 -0.34 1.46e-10 Total body bone mineral density; LUSC cis rs8017423 0.967 rs55667096 chr14:90714798 C/T cg04374321 chr14:90722782 PSMC1 0.77 12.46 0.56 1.64e-29 Mortality in heart failure; LUSC cis rs859767 0.741 rs35599954 chr2:135392481 T/C cg12500956 chr2:135428796 TMEM163 -0.27 -6.11 -0.32 2.8e-9 Neuroticism; LUSC cis rs11971779 0.680 rs10273527 chr7:139036598 A/C cg07862535 chr7:139043722 LUC7L2 -0.56 -7.25 -0.37 2.97e-12 Diisocyanate-induced asthma; LUSC cis rs9788682 1.000 rs7181245 chr15:78814389 C/T cg06917634 chr15:78832804 PSMA4 -0.58 -7.24 -0.37 3.03e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg04586622 chr2:25135609 ADCY3 0.43 9.06 0.44 1.11e-17 Body mass index; LUSC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg00944433 chr1:107599041 PRMT6 0.36 6.66 0.34 1.14e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg01849466 chr14:104193079 ZFYVE21 -0.63 -10.2 -0.49 1.86e-21 Schizophrenia; LUSC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg16506815 chr2:162101123 NA 0.42 6.33 0.33 7.81e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg25767906 chr1:53392781 SCP2 0.48 8.71 0.43 1.47e-16 Monocyte count; LUSC cis rs524023 1.000 rs537246 chr11:64360630 G/A cg19131476 chr11:64387923 NRXN2 0.37 10.03 0.48 7.09e-21 Urate levels in obese individuals; LUSC cis rs4930103 0.534 rs2063550 chr11:1979223 G/C cg06197492 chr11:2016605 H19 0.41 6.78 0.35 5.53e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC cis rs9549260 0.683 rs4941988 chr13:41196006 T/G cg21288729 chr13:41239152 FOXO1 0.6 9.19 0.45 4.44e-18 Red blood cell count; LUSC cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg23260525 chr10:116636907 FAM160B1 0.45 9.83 0.47 3.37e-20 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC cis rs7772486 0.875 rs9390371 chr6:146363180 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.58 0.42 3.62e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7208859 0.623 rs9891166 chr17:29111902 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg19539972 chr4:7069911 GRPEL1 0.4 6.07 0.32 3.52e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg26314531 chr2:26401878 FAM59B -0.69 -9.27 -0.45 2.34e-18 Gut microbiome composition (summer); LUSC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7107174 1.000 rs2510036 chr11:77966788 G/T cg02023728 chr11:77925099 USP35 0.5 7.1 0.36 7.74e-12 Testicular germ cell tumor; LUSC cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 8.36 0.42 1.71e-15 Colorectal cancer; LUSC cis rs2137920 0.836 rs2254617 chr10:50236892 T/G cg27141751 chr10:50231850 C10orf72 0.38 5.73 0.3 2.28e-8 Migraine with aura; LUSC cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg16230307 chr14:35515116 FAM177A1 0.78 10.03 0.48 7.34e-21 Psoriasis; LUSC cis rs2249625 0.584 rs2463744 chr6:72875936 C/T cg18830697 chr6:72922368 RIMS1 -0.36 -7.26 -0.37 2.69e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs7809950 1.000 rs2712201 chr7:107145564 T/C cg23024343 chr7:107201750 COG5 -0.55 -8.69 -0.43 1.62e-16 Coronary artery disease; LUSC cis rs2075371 0.501 rs1643043 chr7:134013902 C/T cg20476274 chr7:133979776 SLC35B4 0.7 11.45 0.53 8.11e-26 Mean platelet volume; LUSC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg00784671 chr22:46762841 CELSR1 -0.54 -6.94 -0.35 2.07e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg08754478 chr10:133766260 PPP2R2D -0.63 -7.99 -0.4 2.27e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs611744 0.608 rs1448152 chr8:109278249 C/T cg21045802 chr8:109455806 TTC35 0.42 6.58 0.34 1.79e-10 Dupuytren's disease; LUSC cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg04034577 chr2:241836375 C2orf54 -0.49 -8.92 -0.44 3.06e-17 Urinary metabolites; LUSC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg09467607 chr2:36825704 FEZ2 0.55 11.62 0.54 1.98e-26 Height; LUSC cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg11161846 chr1:160990452 F11R -0.35 -6.38 -0.33 5.79e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg23711669 chr6:146136114 FBXO30 0.72 10.99 0.52 3.5e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs11250098 0.547 rs2409764 chr8:11281273 C/T cg21775007 chr8:11205619 TDH 0.47 6.63 0.34 1.38e-10 Morning vs. evening chronotype; LUSC cis rs3820928 0.874 rs13430941 chr2:227904447 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.81 -0.39 7.71e-14 Pulmonary function; LUSC cis rs1881396 0.588 rs1881394 chr2:27949052 G/A cg27432699 chr2:27873401 GPN1 0.6 7.29 0.37 2.23e-12 Nonalcoholic fatty liver disease; LUSC cis rs7267979 0.932 rs13040655 chr20:25582197 C/T cg03522245 chr20:25566470 NINL 0.36 5.8 0.3 1.5e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.83 0.3 1.27e-8 Red cell distribution width;Reticulocyte count; LUSC cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg16434002 chr17:42200994 HDAC5 0.44 5.86 0.31 1.12e-8 Total body bone mineral density; LUSC cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.71 -9.46 -0.46 5.81e-19 Chronic sinus infection; LUSC cis rs7577851 0.762 rs2312205 chr2:69704941 A/G cg10773587 chr2:69614142 GFPT1 0.5 6.1 0.32 2.98e-9 Parkinson's disease (age of onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27507545 chr10:103880405 LDB1 0.43 6.34 0.33 7.39e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs672059 1.000 rs659307 chr1:183163078 G/A ch.1.3577855R chr1:183094577 LAMC1 0.55 8.11 0.41 9.74e-15 Hypertriglyceridemia; LUSC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg06671706 chr8:8559999 CLDN23 0.47 6.4 0.33 5.13e-10 Obesity-related traits; LUSC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg06022373 chr22:39101656 GTPBP1 0.83 13.91 0.61 5.22e-35 Menopause (age at onset); LUSC cis rs1997103 0.822 rs10273426 chr7:55417857 G/A cg17469321 chr7:55412551 NA 0.68 10.14 0.49 3.03e-21 QRS interval (sulfonylurea treatment interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17932484 chr13:24463526 MIPEP;PCOTH -0.45 -6.62 -0.34 1.4e-10 Electrocardiographic conduction measures; LUSC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg09877947 chr5:131593287 PDLIM4 0.56 9.17 0.45 4.89e-18 Acylcarnitine levels; LUSC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg08847533 chr14:75593920 NEK9 0.85 15.9 0.66 8.51e-43 Height; LUSC cis rs778371 0.647 rs974321 chr2:233638351 G/A cg08000102 chr2:233561755 GIGYF2 0.78 12.28 0.56 7.42e-29 Schizophrenia; LUSC cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.77 -0.35 5.75e-11 Monocyte percentage of white cells; LUSC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg12463550 chr7:65579703 CRCP -0.56 -8.45 -0.42 8.83e-16 Aortic root size; LUSC cis rs8081395 0.801 rs2665404 chr17:57875396 A/G cg18434674 chr17:58106139 NA 0.27 6.13 0.32 2.54e-9 White blood cell count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18045461 chr22:29601862 EMID1 -0.42 -6.01 -0.31 4.88e-9 Bipolar disorder and schizophrenia; LUSC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg11663144 chr21:46675770 NA -0.44 -7.64 -0.39 2.28e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3806843 0.576 rs246072 chr5:140320426 C/T cg19875535 chr5:140030758 IK 0.37 5.77 0.3 1.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9905704 0.918 rs304293 chr17:56823298 T/G cg12560992 chr17:57184187 TRIM37 0.55 7.84 0.39 6.19e-14 Testicular germ cell tumor; LUSC cis rs1908814 0.516 rs35391955 chr8:11796728 A/C cg21775007 chr8:11205619 TDH 0.46 6.46 0.33 3.75e-10 Neuroticism; LUSC cis rs2274273 0.624 rs7154796 chr14:55771458 T/C cg04306507 chr14:55594613 LGALS3 0.49 10.03 0.48 7.04e-21 Protein biomarker; LUSC cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.13 -0.45 6.67e-18 Body mass index; LUSC cis rs3764563 1.000 rs2283603 chr19:15731128 T/C cg20725493 chr19:15740067 CYP4F8 -0.6 -6.59 -0.34 1.67e-10 Inflammatory biomarkers; LUSC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg15445000 chr17:37608096 MED1 -0.41 -6.87 -0.35 3.18e-11 Glomerular filtration rate (creatinine); LUSC cis rs1577917 0.739 rs2758846 chr6:86349570 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.03 -0.52 2.41e-24 Response to antipsychotic treatment; LUSC cis rs7215564 0.908 rs7501659 chr17:78662061 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs62103177 0.608 rs8088089 chr18:77832154 A/G cg20368463 chr18:77673604 PQLC1 -0.6 -6.4 -0.33 5.33e-10 Opioid sensitivity; LUSC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.78 0.3 1.7e-8 Menopause (age at onset); LUSC trans rs11039798 1.000 rs6485848 chr11:48541517 G/T cg15704280 chr7:45808275 SEPT13 0.69 6.56 0.34 2.06e-10 Axial length; LUSC cis rs1775715 0.835 rs113450267 chr10:32223728 G/A cg04359828 chr10:32216031 ARHGAP12 0.38 6.43 0.33 4.43e-10 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs2235573 0.527 rs139884 chr22:38369976 A/G cg19894588 chr14:64061835 NA 0.54 7.7 0.39 1.5700000000000001e-13 Glioblastoma;Glioma; LUSC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1712517 0.525 rs11191667 chr10:105128898 G/A cg04362960 chr10:104952993 NT5C2 -0.5 -6.65 -0.34 1.21e-10 Migraine; LUSC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg06671706 chr8:8559999 CLDN23 0.51 6.96 0.36 1.8e-11 Obesity-related traits; LUSC cis rs4903214 0.848 rs62006811 chr14:74717699 C/A cg08255017 chr14:74727001 VSX2 -0.49 -6.76 -0.35 6.13e-11 Inflammatory bowel disease; LUSC cis rs9287719 0.935 rs728283 chr2:10750090 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg11663144 chr21:46675770 NA -0.37 -5.96 -0.31 6.35e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg08499158 chr17:42289980 UBTF 0.5 8.66 0.43 2.06e-16 Total body bone mineral density; LUSC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg03433033 chr1:76189801 ACADM 0.72 9.56 0.46 2.58e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7727544 0.582 rs10075459 chr5:131541363 C/G cg14196790 chr5:131705035 SLC22A5 0.45 7.38 0.37 1.28e-12 Blood metabolite levels; LUSC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03352830 chr11:487213 PTDSS2 0.7 8.49 0.42 6.86e-16 Body mass index; LUSC cis rs8009147 1 rs8009147 chr14:104264662 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.45 -0.42 8.92e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg22903471 chr2:27725779 GCKR -0.41 -6.95 -0.36 1.96e-11 Total body bone mineral density; LUSC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 8.86 0.44 4.9e-17 Alzheimer's disease; LUSC cis rs1035144 0.510 rs12432357 chr14:81299468 A/G cg06600135 chr14:81408086 NA -0.56 -8.28 -0.41 2.96e-15 Male sexual orientation; LUSC cis rs10266483 0.774 rs10949901 chr7:63812774 G/A cg24201672 chr7:64023550 ZNF680 0.45 5.86 0.31 1.11e-8 Response to statin therapy; LUSC cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg17063962 chr7:91808500 NA 0.59 9.36 0.46 1.22e-18 Breast cancer; LUSC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg19468946 chr17:37922297 IKZF3 -0.43 -6.83 -0.35 3.97e-11 Self-reported allergy; LUSC cis rs6543140 0.964 rs11886793 chr2:103072220 T/G cg09003973 chr2:102972529 NA 0.54 7.02 0.36 1.25e-11 Blood protein levels; LUSC cis rs9788682 0.747 rs2568497 chr15:78721397 G/T cg06917634 chr15:78832804 PSMA4 0.48 5.85 0.3 1.18e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg05025164 chr4:1340916 KIAA1530 0.45 6.87 0.35 3.19e-11 Obesity-related traits; LUSC cis rs68170813 0.652 rs6957186 chr7:107200592 T/C cg02696742 chr7:106810147 HBP1 -0.64 -8.6 -0.43 3.11e-16 Coronary artery disease; LUSC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg22800045 chr5:56110881 MAP3K1 0.47 6.29 0.33 9.99e-10 Coronary artery disease; LUSC cis rs394563 0.559 rs7753269 chr6:149671360 G/A cg11245181 chr6:149772854 ZC3H12D 0.29 6.24 0.32 1.36e-9 Dupuytren's disease; LUSC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.88 0.4 4.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2692947 0.770 rs4527246 chr2:96560303 T/C cg23100626 chr2:96804247 ASTL 0.26 6.23 0.32 1.42e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs55728055 0.661 rs73162112 chr22:32045449 G/A cg01338084 chr22:32026380 PISD 0.94 6.72 0.35 7.7e-11 Age-related hearing impairment; LUSC cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg18252515 chr7:66147081 NA -1.19 -12.7 -0.57 1.98e-30 Diabetic kidney disease; LUSC cis rs9400467 0.528 rs9689727 chr6:111796563 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.35 -6.57 -0.34 1.98e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs7605827 0.930 rs1997305 chr2:15512383 T/C cg19274914 chr2:15703543 NA 0.46 8.89 0.44 3.98e-17 Educational attainment (years of education); LUSC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs4478858 0.735 rs11583123 chr1:31751772 T/C cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg22681709 chr2:178499509 PDE11A 0.43 6.3 0.33 9.19e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7267979 0.934 rs2257464 chr20:25265872 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.4 0.74 1.26e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg27165867 chr14:105738592 BRF1 -0.5 -7.29 -0.37 2.19e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs9467773 0.565 rs6925047 chr6:26521435 C/G cg11502198 chr6:26597334 ABT1 0.75 11.72 0.54 8.53e-27 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg12963246 chr6:28129442 ZNF389 0.52 7.17 0.37 4.94e-12 Depression; LUSC cis rs6964587 0.967 rs10231496 chr7:91741132 T/C cg01689657 chr7:91764605 CYP51A1 0.31 5.71 0.3 2.51e-8 Breast cancer; LUSC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg08045932 chr20:61659980 NA 0.59 10.39 0.49 4.41e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11890956 chr21:40555474 PSMG1 -0.71 -11.1 -0.52 1.44e-24 Menarche (age at onset); LUSC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.21 0.59 2.34e-32 Total body bone mineral density; LUSC cis rs6933660 0.512 rs13198669 chr6:151799924 A/G cg03627880 chr6:151815985 C6orf97 0.55 6.0 0.31 5.24e-9 Menarche (age at onset); LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg03934478 chr11:495069 RNH1 0.85 10.24 0.49 1.37e-21 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24095222 chr5:161178787 NA -0.4 -6.53 -0.34 2.47e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9467773 1.000 rs9467783 chr6:26542894 C/T cg09904177 chr6:26538194 HMGN4 0.74 13.74 0.6 2.27e-34 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs2495751 chr10:102327260 A/G cg07080220 chr10:102295463 HIF1AN 0.69 8.87 0.44 4.46e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg06552810 chr11:31128660 NA -0.4 -7.12 -0.36 6.5e-12 Red blood cell count; LUSC cis rs10752881 0.967 rs4652758 chr1:182975100 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.39e-23 Colorectal cancer; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg23978390 chr7:1156363 C7orf50 0.45 6.44 0.33 4.21e-10 Longevity;Endometriosis; LUSC cis rs8114671 0.562 rs2223881 chr20:33506463 A/C cg07148914 chr20:33460835 GGT7 0.56 8.53 0.42 5.25e-16 Height; LUSC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg22166914 chr1:53195759 ZYG11B 0.67 11.34 0.53 1.93e-25 Monocyte count; LUSC cis rs10493773 1.000 rs10493774 chr1:86137963 A/G cg17807903 chr1:86174739 ZNHIT6 -0.42 -9.32 -0.45 1.62e-18 Urate levels in overweight individuals; LUSC cis rs7674212 0.539 rs6821617 chr4:104128410 G/A cg16532752 chr4:104119610 CENPE -0.46 -6.66 -0.34 1.14e-10 Type 2 diabetes; LUSC trans rs61931739 0.534 rs2389276 chr12:34097891 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.74 0.51 2.52e-23 Morning vs. evening chronotype; LUSC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg18654377 chr3:49208889 KLHDC8B -0.54 -7.22 -0.37 3.62e-12 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs701145 0.529 rs355746 chr3:153961627 C/G cg17054900 chr3:154042577 DHX36 0.46 6.06 0.31 3.63e-9 Coronary artery disease; LUSC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg16606324 chr3:10149918 C3orf24 0.58 8.43 0.42 1.07e-15 Alzheimer's disease; LUSC cis rs983392 0.805 rs10897011 chr11:59961427 G/A cg20284999 chr11:59952153 MS4A6A -0.39 -6.49 -0.33 3.14e-10 Alzheimer's disease (late onset); LUSC cis rs68170813 0.559 rs76020313 chr7:106877468 A/G cg02696742 chr7:106810147 HBP1 -0.64 -9.58 -0.46 2.35e-19 Coronary artery disease; LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg11062466 chr8:58055876 NA 0.66 9.08 0.44 9.89e-18 Developmental language disorder (linguistic errors); LUSC cis rs765787 0.530 rs3759892 chr15:45542709 A/G cg25801113 chr15:45476975 SHF -0.36 -7.04 -0.36 1.11e-11 Uric acid levels; LUSC trans rs3733585 0.598 rs28677023 chr4:9958326 C/A cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs559928 0.606 rs11231726 chr11:63987339 C/T cg24687543 chr11:63912206 MACROD1 0.45 5.76 0.3 1.9e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs8017423 0.904 rs11622257 chr14:90715014 C/T cg04374321 chr14:90722782 PSMC1 -0.7 -10.71 -0.51 3.25e-23 Mortality in heart failure; LUSC cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg02527881 chr3:46936655 PTH1R -0.39 -6.79 -0.35 5.04e-11 Colorectal cancer; LUSC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg04972856 chr6:88032051 C6orf162;GJB7 0.46 8.96 0.44 2.31e-17 Monocyte percentage of white cells; LUSC cis rs7647973 0.626 rs4855882 chr3:49715354 G/T cg13072238 chr3:49761600 GMPPB -0.73 -8.94 -0.44 2.68e-17 Menarche (age at onset); LUSC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.13 -0.48 3.34e-21 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.53e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs10751667 0.666 rs10902242 chr11:949700 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.46 0.33 3.71e-10 Alzheimer's disease (late onset); LUSC cis rs3008870 0.920 rs3008865 chr1:67402838 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.13 0.64 9.65e-40 Lymphocyte percentage of white cells; LUSC cis rs2439831 0.850 rs7181039 chr15:44179112 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.68 0.34 9.98e-11 Lung cancer in ever smokers; LUSC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg05855489 chr10:104503620 C10orf26 0.6 9.61 0.47 1.88e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.93 8.97 0.44 2.23e-17 Lung cancer in ever smokers; LUSC cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg23711669 chr6:146136114 FBXO30 -0.89 -16.79 -0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.933 rs10779218 chr12:86320053 A/G cg18827107 chr12:86230957 RASSF9 -0.41 -5.99 -0.31 5.42e-9 Major depressive disorder; LUSC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg23791538 chr6:167370224 RNASET2 0.42 6.79 0.35 5.12e-11 Crohn's disease; LUSC cis rs4132509 0.793 rs10803152 chr1:243846167 C/A cg21452805 chr1:244014465 NA 0.65 6.93 0.35 2.15e-11 RR interval (heart rate); LUSC cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg00990874 chr7:1149470 C7orf50 -0.46 -6.08 -0.32 3.31e-9 Bronchopulmonary dysplasia; LUSC cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg04518342 chr5:131593106 PDLIM4 0.36 6.64 0.34 1.29e-10 Blood metabolite levels; LUSC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg16339924 chr4:17578868 LAP3 0.55 8.27 0.41 3.16e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg24642844 chr7:1081250 C7orf50 -0.74 -6.88 -0.35 3e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg22963979 chr7:1858916 MAD1L1 -0.59 -9.12 -0.45 6.98e-18 Bipolar disorder and schizophrenia; LUSC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.05 0.31 3.97e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs765787 0.530 rs4238376 chr15:45541887 T/C cg25801113 chr15:45476975 SHF 0.34 7.04 0.36 1.13e-11 Uric acid levels; LUSC cis rs2011503 0.941 rs10422893 chr19:19372185 G/C cg11584989 chr19:19387371 SF4 0.6 7.33 0.37 1.78e-12 Bipolar disorder; LUSC cis rs3770081 1.000 rs12617717 chr2:86342303 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -1.07 -7.21 -0.37 3.85e-12 Facial emotion recognition (sad faces); LUSC cis rs3820928 0.874 rs10183633 chr2:227887828 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.69 -0.39 1.66e-13 Pulmonary function; LUSC cis rs7605827 0.930 rs4668927 chr2:15706683 C/T cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.64e-17 Educational attainment (years of education); LUSC cis rs16912285 0.585 rs7950920 chr11:24356464 G/A ch.11.24196551F chr11:24239977 NA 0.85 8.17 0.41 6.45e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7815909 0.605 rs77831403 chr8:57202791 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.6 6.86 0.35 3.39e-11 Height; LUSC cis rs4604732 0.536 rs12037221 chr1:247631212 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.87 0.35 3.13e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg23093090 chr10:104574429 C10orf26 -0.38 -7.1 -0.36 7.78e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20385508 chr2:128180829 PROC -0.42 -6.48 -0.33 3.22e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6138458 0.828 rs6138466 chr20:24997137 A/G cg06937882 chr20:24974362 C20orf3 -0.33 -5.97 -0.31 5.91e-9 Blood protein levels; LUSC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg00310523 chr12:86230176 RASSF9 -0.43 -8.1 -0.41 1.07e-14 Major depressive disorder; LUSC cis rs67311347 0.713 rs114569261 chr3:40314580 G/A cg09455208 chr3:40491958 NA 0.5 9.12 0.45 7e-18 Renal cell carcinoma; LUSC cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg21643547 chr1:205240462 TMCC2 -0.53 -10.22 -0.49 1.63e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9303401 0.659 rs34382037 chr17:56643550 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg07936489 chr17:37558343 FBXL20 -0.7 -9.71 -0.47 8.41e-20 Glomerular filtration rate (creatinine); LUSC cis rs2637266 0.935 rs1866891 chr10:78396941 C/A cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.95e-13 Pulmonary function; LUSC cis rs80130819 0.688 rs2634672 chr12:48649640 G/A cg24011408 chr12:48396354 COL2A1 0.46 5.84 0.3 1.22e-8 Prostate cancer; LUSC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg20203395 chr5:56204925 C5orf35 -0.57 -8.02 -0.4 1.75e-14 Coronary artery disease; LUSC cis rs7605827 0.704 rs2160695 chr2:15673478 T/A cg19274914 chr2:15703543 NA 0.45 8.67 0.43 1.97e-16 Educational attainment (years of education); LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg13560548 chr3:10150139 C3orf24 0.48 6.6 0.34 1.6e-10 Alzheimer's disease; LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg25767906 chr1:53392781 SCP2 0.47 8.41 0.42 1.22e-15 Monocyte count; LUSC cis rs2040771 0.740 rs9605960 chr22:19214636 G/C cg02655711 chr22:19163373 SLC25A1 0.47 8.4 0.42 1.28e-15 Metabolite levels (small molecules and protein measures); LUSC cis rs9549367 0.789 rs2287251 chr13:113889499 A/G cg18105134 chr13:113819100 PROZ -0.67 -9.47 -0.46 5.48e-19 Platelet distribution width; LUSC cis rs4851254 0.961 rs13011181 chr2:100732446 T/C cg07810366 chr2:100720526 AFF3 -0.38 -5.99 -0.31 5.34e-9 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15560632 chr7:100183617 LRCH4;FBXO24 -0.4 -5.95 -0.31 6.86e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg05234568 chr11:5960015 NA -0.54 -8.24 -0.41 4.05e-15 DNA methylation (variation); LUSC trans rs453301 0.571 rs330054 chr8:9088291 G/A cg15556689 chr8:8085844 FLJ10661 -0.56 -8.47 -0.42 7.93e-16 Joint mobility (Beighton score); LUSC cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg15103426 chr22:29168792 CCDC117 0.46 5.97 0.31 6.04e-9 Lymphocyte counts; LUSC trans rs11098499 0.731 rs9995026 chr4:120490499 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.73 0.35 7.39e-11 Corneal astigmatism; LUSC cis rs16854884 0.657 rs35309714 chr3:143735011 T/A cg06585982 chr3:143692056 C3orf58 0.5 8.13 0.41 8.55e-15 Economic and political preferences (feminism/equality); LUSC cis rs868036 0.645 rs4492996 chr15:68113240 A/G cg08079166 chr15:68083412 MAP2K5 0.4 7.11 0.36 7.05e-12 Restless legs syndrome; LUSC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg18512352 chr11:47633146 NA -0.46 -9.25 -0.45 2.73e-18 Subjective well-being; LUSC cis rs6556937 0.562 rs31248 chr5:96014683 A/G cg07690455 chr5:95997198 CAST 0.49 6.76 0.35 6.3e-11 Blood protein levels; LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg13685833 chr1:53393034 SCP2 0.38 5.74 0.3 2.17e-8 Monocyte count; LUSC cis rs4319547 0.661 rs10846830 chr12:122897220 C/G cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.33 -0.41 2.13e-15 Body mass index; LUSC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg13393036 chr8:95962371 TP53INP1 -0.46 -9.98 -0.48 1.03e-20 Type 2 diabetes; LUSC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg20295408 chr7:1910781 MAD1L1 -0.4 -5.79 -0.3 1.61e-8 Bipolar disorder and schizophrenia; LUSC cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.72 -0.3 2.35e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg02825527 chr7:2087843 MAD1L1 -0.5 -5.73 -0.3 2.29e-8 Bipolar disorder; LUSC cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg14664628 chr15:75095509 CSK 0.43 6.18 0.32 1.91e-9 Systemic lupus erythematosus; LUSC cis rs9527 0.590 rs12414232 chr10:104914491 A/T cg05855489 chr10:104503620 C10orf26 0.52 7.98 0.4 2.38e-14 Arsenic metabolism; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27006547 chr11:62606509 WDR74 0.53 8.05 0.4 1.42e-14 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4660306 1.000 rs2356559 chr1:45981512 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.37 -5.8 -0.3 1.56e-8 Homocysteine levels; LUSC cis rs9462027 0.628 rs7756405 chr6:34722659 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.93 -0.31 7.62e-9 Systemic lupus erythematosus; LUSC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.98 0.4 2.38e-14 Parkinson's disease; LUSC cis rs8077889 0.956 rs4793025 chr17:41841621 T/C cg26893861 chr17:41843967 DUSP3 1.01 14.98 0.63 3.74e-39 Triglycerides; LUSC cis rs911186 0.730 rs2393911 chr6:27057079 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.37 -5.91 -0.31 8.62e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs9329221 0.638 rs12543645 chr8:10246325 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.26 -0.37 2.68e-12 Neuroticism; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg25683204 chr20:34129839 ERGIC3 -0.45 -6.25 -0.32 1.26e-9 Hepatitis; LUSC cis rs10752881 0.935 rs10797834 chr1:183048749 T/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.95 0.51 4.59e-24 Colorectal cancer; LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg13395646 chr4:1353034 KIAA1530 0.58 8.78 0.43 8.89e-17 Obesity-related traits; LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg00166722 chr3:10149974 C3orf24 0.58 7.81 0.39 7.42e-14 Alzheimer's disease; LUSC cis rs1008375 0.618 rs13129002 chr4:17567513 A/G cg18681998 chr4:17616180 MED28 0.75 11.18 0.52 7.08e-25 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg14664628 chr15:75095509 CSK -0.81 -12.51 -0.56 1.03e-29 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7647973 0.667 rs6446286 chr3:49681704 A/G cg13072238 chr3:49761600 GMPPB -0.71 -8.92 -0.44 3.03e-17 Menarche (age at onset); LUSC cis rs2073300 1.000 rs79169006 chr20:23443535 A/T cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11252926 0.831 rs816570 chr10:680475 C/T cg18196295 chr10:418757 DIP2C -0.41 -6.18 -0.32 1.89e-9 Psychosis in Alzheimer's disease; LUSC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.59 0.57 5.03e-30 Menopause (age at onset); LUSC cis rs7178572 0.524 rs1473922 chr15:77656798 G/T cg22256960 chr15:77711686 NA -0.51 -8.09 -0.4 1.11e-14 Type 2 diabetes; LUSC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg11764359 chr7:65958608 NA 0.7 10.74 0.51 2.63e-23 Aortic root size; LUSC cis rs9287719 0.639 rs2357650 chr2:10696877 C/T cg00105475 chr2:10696890 NA 0.43 7.16 0.36 5.22e-12 Prostate cancer; LUSC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 7.33 0.37 1.78e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12310956 0.510 rs10129020 chr12:33858936 T/G cg13010199 chr12:38710504 ALG10B 0.43 6.43 0.33 4.51e-10 Morning vs. evening chronotype; LUSC cis rs4474465 1.000 rs11237510 chr11:78173584 G/A cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00140813 chr16:28857836 TUFM -0.48 -6.08 -0.32 3.37e-9 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.17 0.52 7.95e-25 Menopause (age at onset); LUSC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg20135002 chr11:47629003 NA -0.51 -8.0 -0.4 2.13e-14 Subjective well-being; LUSC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.5 -6.47 -0.33 3.5e-10 Multiple sclerosis; LUSC trans rs11764590 0.715 rs11760737 chr7:2104055 T/C cg25206134 chr2:45395956 NA 0.56 6.12 0.32 2.6e-9 Neuroticism; LUSC trans rs7939886 0.920 rs17145425 chr11:55950030 A/G cg15704280 chr7:45808275 SEPT13 0.9 6.94 0.36 2.07e-11 Myopia (pathological); LUSC trans rs7647973 0.560 rs77473999 chr3:49777660 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.59 6.84 0.35 3.81e-11 Menarche (age at onset); LUSC cis rs9354352 0.967 rs6455062 chr6:66694131 T/A cg07460842 chr6:66804631 NA 0.68 9.91 0.48 1.78e-20 Initial pursuit acceleration in psychotic disorders; LUSC cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg05347473 chr6:146136440 FBXO30 -0.49 -8.24 -0.41 3.87e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04100724 chr12:92539208 BTG1 0.44 6.8 0.35 4.79e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7709377 0.595 rs1644268 chr5:115640808 G/T cg23108291 chr5:115420582 COMMD10 -0.4 -5.66 -0.3 3.26e-8 Metabolite levels (X-11787); LUSC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg16434002 chr17:42200994 HDAC5 -0.43 -5.99 -0.31 5.34e-9 Total body bone mineral density; LUSC cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg22834771 chr12:69754056 YEATS4 -0.44 -6.63 -0.34 1.39e-10 Blood protein levels; LUSC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.96e-13 Obesity-related traits; LUSC cis rs7659604 0.540 rs9998385 chr4:122676673 C/T cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs5758511 0.689 rs17478227 chr22:42654327 C/G cg00645731 chr22:42541494 CYP2D7P1 -0.5 -7.7 -0.39 1.6e-13 Birth weight; LUSC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg00745463 chr17:30367425 LRRC37B -0.74 -9.03 -0.44 1.42e-17 Hip circumference adjusted for BMI; LUSC cis rs10791323 0.569 rs10736608 chr11:133740048 C/T cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.84e-12 Childhood ear infection; LUSC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 3.01e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg23719950 chr11:63933701 MACROD1 -0.58 -7.42 -0.38 9.69e-13 Mean platelet volume; LUSC cis rs7267979 0.966 rs2482918 chr20:25412135 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.83 -0.7 1.98e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs977987 0.843 rs11149824 chr16:75431830 C/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.77 -0.35 5.88e-11 Dupuytren's disease; LUSC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs2439831 0.850 rs2228368 chr15:44102010 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.21 0.45 3.79e-18 Lung cancer in ever smokers; LUSC cis rs1784581 0.722 rs1789993 chr6:162398976 T/C cg17173639 chr6:162384350 PARK2 -0.66 -11.54 -0.53 3.67e-26 Itch intensity from mosquito bite; LUSC trans rs2243480 1.000 rs35046236 chr7:65408613 T/C cg10756647 chr7:56101905 PSPH 0.86 8.4 0.42 1.27e-15 Diabetic kidney disease; LUSC cis rs7715806 0.500 rs17649266 chr5:75001252 C/T cg19683494 chr5:74908142 NA -0.54 -7.55 -0.38 4.21e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg06145435 chr7:1022769 CYP2W1 0.3 6.32 0.33 8.27e-10 Longevity;Endometriosis; LUSC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.61 9.25 0.45 2.72e-18 Height; LUSC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 8.26 0.41 3.51e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7267979 1.000 rs2856 chr20:25433536 T/C cg08601574 chr20:25228251 PYGB 0.43 6.64 0.34 1.28e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2629540 0.924 rs1545910 chr10:126428145 G/C cg08799069 chr10:126477246 METTL10 -0.7 -10.22 -0.49 1.66e-21 Cocaine dependence; LUSC cis rs7584330 0.554 rs9646713 chr2:238443542 T/C cg14458575 chr2:238380390 NA 0.43 5.71 0.3 2.47e-8 Prostate cancer; LUSC cis rs929354 0.772 rs1182438 chr7:157027438 G/A cg17757837 chr7:157058334 UBE3C -0.82 -13.32 -0.59 9.02e-33 Body mass index; LUSC cis rs2692947 0.673 rs2229169 chr2:96780716 T/G cg22654517 chr2:96458247 NA -0.31 -5.87 -0.31 1.05e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7539409 0.764 rs4001465 chr1:84285304 T/C cg10977910 chr1:84465055 TTLL7 0.64 5.89 0.31 9.36e-9 Alzheimer's disease; LUSC cis rs76793172 1.000 rs7249022 chr19:46354558 G/A cg00442267 chr19:46317840 RSPH6A -0.5 -5.69 -0.3 2.77e-8 Eosinophil counts; LUSC cis rs34779708 0.966 rs7077242 chr10:35481965 A/C cg04310649 chr10:35416472 CREM 0.44 6.89 0.35 2.73e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03934478 chr11:495069 RNH1 -0.83 -9.95 -0.48 1.36e-20 Body mass index; LUSC cis rs11048434 0.736 rs12424026 chr12:9110993 T/C cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg03433033 chr1:76189801 ACADM 0.8 13.3 0.59 1.14e-32 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01708711 chr7:75959031 YWHAG 0.45 6.69 0.34 9.5e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7520050 0.778 rs3014238 chr1:46090214 A/G cg06784218 chr1:46089804 CCDC17 -0.32 -6.31 -0.33 8.9e-10 Red blood cell count;Reticulocyte count; LUSC cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg08807101 chr21:30365312 RNF160 0.81 15.55 0.65 2.11e-41 Dental caries; LUSC cis rs4959270 0.836 rs10900950 chr6:462968 C/T cg09757644 chr6:447497 NA 0.29 5.79 0.3 1.61e-8 Limited cutaneous systemic scleroderma; LUSC cis rs752010 0.714 rs2182606 chr1:42082375 T/C cg06885757 chr1:42089581 HIVEP3 0.48 10.28 0.49 1.02e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg24977027 chr2:88469347 THNSL2 0.56 5.84 0.3 1.21e-8 Plasma clusterin levels; LUSC cis rs1322512 0.917 rs1727049 chr6:152942962 A/G cg27316956 chr6:152958899 SYNE1 -0.35 -5.77 -0.3 1.77e-8 Tonometry; LUSC trans rs208515 0.525 rs10944871 chr6:66690306 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.38 0.62 7.6e-37 Exhaled nitric oxide levels; LUSC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.78 -12.48 -0.56 1.39e-29 Hip circumference adjusted for BMI; LUSC trans rs6788232 0.908 rs9866149 chr3:138731753 G/A cg05026658 chr7:102918083 DPY19L2P2 -0.55 -6.14 -0.32 2.32e-9 Male-pattern baldness; LUSC cis rs9811920 0.715 rs6810262 chr3:99906342 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.32 6.11 0.32 2.76e-9 Axial length; LUSC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg07701084 chr6:150067640 NUP43 0.58 8.92 0.44 3.05e-17 Lung cancer; LUSC cis rs4474465 1.000 rs7934678 chr11:78192968 G/A cg27205649 chr11:78285834 NARS2 -0.52 -6.02 -0.31 4.59e-9 Alzheimer's disease (survival time); LUSC cis rs79839061 0.610 rs78590562 chr4:869715 C/T cg14530993 chr4:882597 GAK 0.72 7.42 0.38 1e-12 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg09034736 chr1:150693464 HORMAD1 0.41 5.65 0.3 3.51e-8 Melanoma; LUSC cis rs524023 0.881 rs544838 chr11:64429059 T/C cg07220939 chr11:64358617 SLC22A12 -0.22 -5.7 -0.3 2.69e-8 Urate levels in obese individuals; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02123667 chr8:127570702 FAM84B -0.48 -6.38 -0.33 6.04e-10 Bipolar disorder and schizophrenia; LUSC trans rs7647973 0.626 rs2329021 chr3:49679072 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.87 -0.35 3.11e-11 Menarche (age at onset); LUSC cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.51 0.69 3.59e-49 Chronic sinus infection; LUSC cis rs2274273 1.000 rs72718804 chr14:55630610 G/A cg04306507 chr14:55594613 LGALS3 0.55 12.02 0.55 6.51e-28 Protein biomarker; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.54 8.92 0.44 3.03e-17 Prudent dietary pattern; LUSC cis rs875971 0.830 rs12673450 chr7:66009220 G/A cg12463550 chr7:65579703 CRCP 0.54 7.68 0.39 1.75e-13 Aortic root size; LUSC cis rs4285028 0.948 rs12488851 chr3:121687192 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.68 -0.47 1.07e-19 Multiple sclerosis; LUSC cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg00071950 chr4:10020882 SLC2A9 0.64 10.77 0.51 2e-23 Bone mineral density; LUSC cis rs7580658 0.864 rs10928761 chr2:128003247 C/T cg09760422 chr2:128146352 NA -0.28 -6.11 -0.32 2.79e-9 Protein C levels; LUSC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg00343986 chr7:65444356 GUSB -0.39 -5.98 -0.31 5.79e-9 Aortic root size; LUSC trans rs800082 0.646 rs2717394 chr3:144280612 A/T cg24215973 chr2:240111563 HDAC4 0.6 9.56 0.46 2.65e-19 Smoking behavior; LUSC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg21028142 chr17:79581711 NPLOC4 0.34 8.17 0.41 6.45e-15 Eye color traits; LUSC cis rs477692 0.875 rs7091540 chr10:131420276 C/T cg05714579 chr10:131428358 MGMT -0.52 -7.9 -0.4 4e-14 Response to temozolomide; LUSC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg07636037 chr3:49044803 WDR6 0.56 5.73 0.3 2.24e-8 Menarche (age at onset); LUSC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg12257692 chr3:49977190 RBM6 0.23 6.3 0.33 9.34e-10 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg17366294 chr4:99064904 C4orf37 0.5 8.54 0.42 4.84e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs4974559 0.594 rs59544360 chr4:1313575 G/T cg02980000 chr4:1222292 CTBP1 0.83 8.93 0.44 2.99e-17 Systolic blood pressure; LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg05165339 chr4:1420672 NA -0.29 -6.56 -0.34 2.07e-10 Longevity; LUSC cis rs13223928 0.565 rs10951053 chr7:3155579 C/T cg19214707 chr7:3157722 NA -0.49 -9.52 -0.46 3.6e-19 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs7771547 0.519 rs4713973 chr6:36382044 A/G cg07856975 chr6:36356162 ETV7 0.42 6.22 0.32 1.51e-9 Platelet distribution width; LUSC cis rs554111 0.656 rs4654900 chr1:21422021 G/C cg01072550 chr1:21505969 NA 0.39 6.01 0.31 4.82e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs16917546 0.933 rs10995238 chr10:64387108 A/G cg03961010 chr10:64397487 ZNF365 0.43 6.79 0.35 4.99e-11 Basal cell carcinoma; LUSC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg27432699 chr2:27873401 GPN1 -0.59 -8.94 -0.44 2.7e-17 Total body bone mineral density; LUSC cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.56 7.68 0.39 1.78e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg22160112 chr17:46696077 NA 0.45 6.19 0.32 1.8e-9 Mosquito bite size; LUSC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg05347473 chr6:146136440 FBXO30 0.55 9.73 0.47 7.59e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg00343986 chr7:65444356 GUSB 0.47 7.09 0.36 7.84e-12 Aortic root size; LUSC cis rs2051773 0.567 rs11024113 chr11:17042444 G/A cg15084286 chr11:17036142 PLEKHA7 0.44 5.64 0.3 3.57e-8 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; LUSC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg12311346 chr5:56204834 C5orf35 -0.81 -13.01 -0.58 1.39e-31 Coronary artery disease; LUSC cis rs2688608 0.836 rs2675668 chr10:75636148 G/A cg17411546 chr10:75410026 SYNPO2L -0.41 -5.84 -0.3 1.23e-8 Inflammatory bowel disease; LUSC cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg19378624 chr17:45501242 LOC100272146;C17orf57 0.39 6.66 0.34 1.09e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs113835537 0.597 rs2305534 chr11:66313203 T/C cg24851651 chr11:66362959 CCS 0.53 7.86 0.4 5.33e-14 Airway imaging phenotypes; LUSC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg12564285 chr5:131593104 PDLIM4 -0.34 -6.15 -0.32 2.2e-9 Blood metabolite levels; LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg01802117 chr1:53393560 SCP2 -0.39 -6.36 -0.33 6.81e-10 Monocyte count; LUSC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg04733989 chr22:42467013 NAGA 0.55 8.55 0.42 4.57e-16 Schizophrenia; LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg22907277 chr7:1156413 C7orf50 0.68 7.3 0.37 2.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.14 0.32 2.33e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.03e-34 Prostate cancer; LUSC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg12927641 chr6:109611667 NA -0.42 -7.5 -0.38 5.9e-13 Reticulocyte fraction of red cells; LUSC cis rs5756931 0.503 rs5750542 chr22:38534507 T/C cg25457927 chr22:38595422 NA -0.35 -7.01 -0.36 1.29e-11 Triglycerides; LUSC cis rs10465746 0.846 rs9700285 chr1:84336685 G/A cg10977910 chr1:84465055 TTLL7 0.44 6.21 0.32 1.54e-9 Obesity-related traits; LUSC cis rs4851254 0.550 rs13402289 chr2:100659389 C/T cg22139774 chr2:100720529 AFF3 -0.44 -5.75 -0.3 2.06e-8 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.752 rs13075253 chr3:134329600 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.78 12.62 0.57 3.86e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9814567 1.000 rs9864346 chr3:134312352 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg00745463 chr17:30367425 LRRC37B -0.83 -9.23 -0.45 3.07e-18 Hip circumference adjusted for BMI; LUSC cis rs9534288 0.664 rs1926447 chr13:46629944 C/T cg15192986 chr13:46630673 CPB2 0.66 10.37 0.49 5.03e-22 Blood protein levels; LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg22166914 chr1:53195759 ZYG11B -0.62 -10.34 -0.49 6.45e-22 Monocyte count; LUSC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg04800585 chr6:26043546 HIST1H2BB 0.39 5.92 0.31 8.07e-9 Intelligence (multi-trait analysis); LUSC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg26897989 chr16:1907736 C16orf73 0.46 7.36 0.37 1.45e-12 Glomerular filtration rate in chronic kidney disease; LUSC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg26695010 chr11:65641043 EFEMP2 -0.47 -7.14 -0.36 5.95e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs72960926 0.744 rs72950570 chr6:74913740 T/C cg03266952 chr6:74778945 NA -0.78 -6.22 -0.32 1.5e-9 Metabolite levels (MHPG); LUSC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg13531842 chr10:38383804 ZNF37A -0.47 -7.35 -0.37 1.49e-12 Extrinsic epigenetic age acceleration; LUSC cis rs7607369 0.559 rs4674339 chr2:219659787 C/G cg02176678 chr2:219576539 TTLL4 -0.53 -9.51 -0.46 4.03e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs240764 0.658 rs9485410 chr6:101261007 A/G cg09795085 chr6:101329169 ASCC3 0.46 6.66 0.34 1.13e-10 Neuroticism; LUSC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg18252515 chr7:66147081 NA -1.22 -13.44 -0.59 3.3e-33 Diabetic kidney disease; LUSC cis rs2816062 0.775 rs2745315 chr1:18897118 G/A cg18795169 chr1:18902165 NA -1.02 -24.9 -0.81 4.01e-78 Urate levels in lean individuals; LUSC cis rs13315871 0.929 rs13080508 chr3:58300116 G/A cg12435725 chr3:58293450 RPP14 -0.68 -7.18 -0.37 4.62e-12 Cholesterol, total; LUSC cis rs17125944 0.686 rs7158645 chr14:53332152 C/T cg00686598 chr14:53173677 PSMC6 -0.64 -5.98 -0.31 5.6e-9 Alzheimer's disease (late onset); LUSC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg17507749 chr15:85114479 UBE2QP1 0.69 8.78 0.43 8.54e-17 Schizophrenia; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.29e-12 Platelet count; LUSC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg03804128 chr16:635623 NA 0.31 5.99 0.31 5.53e-9 Height; LUSC cis rs17253792 0.822 rs78395034 chr14:56069783 G/A cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs644799 0.526 rs530914 chr11:95632156 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.57 8.49 0.42 6.87e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg02353165 chr6:42928485 GNMT 0.67 11.84 0.54 3.15e-27 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.89 -12.67 -0.57 2.7e-30 Platelet count; LUSC cis rs7200543 1.000 rs6498541 chr16:15140657 A/G cg03427771 chr16:15082598 PDXDC1 -0.4 -5.78 -0.3 1.69e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.1 -0.36 7.7e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg03241323 chr2:187454863 ITGAV 0.39 6.14 0.32 2.28e-9 Mosquito bite size; LUSC cis rs612683 0.599 rs2809823 chr1:101003762 C/A cg09408571 chr1:101003634 GPR88 0.37 7.51 0.38 5.55e-13 Breast cancer; LUSC trans rs61931739 0.534 rs11053016 chr12:34104372 C/T cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg09184832 chr6:79620586 NA -0.41 -6.34 -0.33 7.41e-10 Intelligence (multi-trait analysis); LUSC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 9.76 0.47 5.99e-20 Eosinophil percentage of white cells; LUSC cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg02527881 chr3:46936655 PTH1R -0.38 -6.62 -0.34 1.47e-10 Colorectal cancer; LUSC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.87 -0.31 1.04e-8 Lung cancer; LUSC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg18352616 chr4:3374830 RGS12 0.33 6.61 0.34 1.51e-10 Serum sulfate level; LUSC trans rs12200782 0.932 rs12189841 chr6:26544798 A/T cg18180407 chr1:55047736 ACOT11 0.48 5.97 0.31 6.12e-9 Small cell lung carcinoma; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg07904447 chr11:94823506 ENDOD1 -0.5 -6.22 -0.32 1.48e-9 Neuroticism; LUSC cis rs10740039 0.516 rs7088259 chr10:62318852 T/C cg18175470 chr10:62150864 ANK3 -0.45 -6.89 -0.35 2.87e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg26897989 chr16:1907736 C16orf73 -0.42 -6.63 -0.34 1.37e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs611744 0.647 rs864166 chr8:109249300 C/G cg21045802 chr8:109455806 TTC35 0.43 6.57 0.34 1.92e-10 Dupuytren's disease; LUSC cis rs6546550 0.901 rs10167142 chr2:70062360 T/C cg02498382 chr2:70120550 SNRNP27 -0.29 -7.17 -0.37 4.87e-12 Prevalent atrial fibrillation; LUSC cis rs2486288 0.656 rs1706770 chr15:45575062 T/C cg26924012 chr15:45694286 SPATA5L1 -0.76 -11.11 -0.52 1.32e-24 Glomerular filtration rate; LUSC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg08847533 chr14:75593920 NEK9 0.85 15.82 0.65 1.82e-42 Height; LUSC trans rs62103177 1.000 rs62103177 chr18:77624479 G/A cg05926928 chr17:57297772 GDPD1 1.39 16.09 0.66 1.62e-43 Opioid sensitivity; LUSC cis rs4888262 0.526 rs13330282 chr16:74572373 C/T cg01733217 chr16:74700730 RFWD3 0.75 12.49 0.56 1.25e-29 Testicular germ cell tumor; LUSC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.58 9.09 0.45 8.89e-18 Total body bone mineral density; LUSC cis rs34779708 0.966 rs17591781 chr10:35498538 G/A cg04310649 chr10:35416472 CREM -0.41 -6.32 -0.33 8.17e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs911555 0.755 rs8016676 chr14:103904842 C/A cg24130564 chr14:104152367 KLC1 0.45 6.54 0.34 2.3e-10 Intelligence (multi-trait analysis); LUSC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg16414030 chr3:133502952 NA -0.54 -8.74 -0.43 1.14e-16 Iron status biomarkers; LUSC cis rs7267979 0.932 rs1541061 chr20:25521057 G/A cg03522245 chr20:25566470 NINL 0.37 5.96 0.31 6.4e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7903847 0.642 rs10882926 chr10:99160690 C/T cg08345082 chr10:99160200 RRP12 0.31 6.37 0.33 6.44e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.43 -0.42 1.03e-15 Total body bone mineral density; LUSC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 10.01 0.48 8.74e-21 Eosinophil percentage of white cells; LUSC cis rs3931020 0.657 rs277368 chr1:75230606 C/T cg10128416 chr1:75198403 TYW3;CRYZ -0.64 -8.41 -0.42 1.17e-15 Resistin levels; LUSC cis rs6736093 0.796 rs13006228 chr2:112806738 G/A cg12686935 chr2:112915763 FBLN7 -0.4 -6.35 -0.33 7.04e-10 Coronary artery disease; LUSC cis rs6599077 0.950 rs4676562 chr3:40105039 A/G cg13683864 chr3:40499215 RPL14 -0.61 -7.6 -0.38 3.09e-13 Sleep-related phenotypes; LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg24060327 chr5:131705240 SLC22A5 0.67 11.03 0.52 2.42e-24 Breast cancer; LUSC trans rs61931739 0.534 rs11052960 chr12:33997754 A/T cg13010199 chr12:38710504 ALG10B 0.56 8.27 0.41 3.18e-15 Morning vs. evening chronotype; LUSC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg10169327 chr19:45448959 APOC2 0.31 6.66 0.34 1.15e-10 Blood protein levels; LUSC cis rs253664 0.846 rs166195 chr3:138093164 T/C cg25188949 chr3:137893707 DBR1 -0.49 -5.72 -0.3 2.37e-8 Body mass index; LUSC trans rs11088226 0.581 rs2833856 chr21:33877691 A/G cg09050820 chr6:167586206 TCP10L2 -0.49 -7.69 -0.39 1.69e-13 Gastritis; LUSC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.47 0.33 3.59e-10 Lung cancer; LUSC cis rs921665 0.831 rs2242084 chr2:3196040 A/G cg02624386 chr2:3182749 NA 0.59 6.61 0.34 1.56e-10 World class endurance athleticism; LUSC trans rs8073060 0.586 rs225288 chr17:33929291 G/A cg19694781 chr19:47549865 TMEM160 -1.15 -18.23 -0.71 5.05e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg26335602 chr6:28129616 ZNF389 0.49 6.56 0.34 2e-10 Parkinson's disease; LUSC cis rs9902453 0.845 rs2617875 chr17:28090024 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.07 0.44 1.02e-17 Coffee consumption (cups per day); LUSC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg22920501 chr2:26401640 FAM59B 0.72 9.97 0.48 1.17e-20 Gut microbiome composition (summer); LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg21138405 chr5:131827807 IRF1 0.56 10.96 0.51 4.23e-24 Asthma (sex interaction); LUSC cis rs478304 0.651 rs11227279 chr11:65495211 G/A cg05805236 chr11:65401703 PCNXL3 -0.57 -9.23 -0.45 3.31e-18 Acne (severe); LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg02475777 chr4:1388615 CRIPAK -0.61 -9.05 -0.44 1.22e-17 Longevity; LUSC cis rs7707921 0.881 rs73134739 chr5:81370760 T/C cg15871215 chr5:81402204 ATG10 -0.44 -6.44 -0.33 4.13e-10 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19977408 chr4:129209103 PGRMC2 0.45 6.95 0.36 1.91e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7833986 0.501 rs2719258 chr8:56941389 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.72 11.87 0.54 2.28e-27 Height; LUSC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.25 0.37 3e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1506636 1.000 rs641491 chr7:123399726 C/A cg03229431 chr7:123269106 ASB15 0.65 10.7 0.51 3.66e-23 Plateletcrit;Platelet count; LUSC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg07701084 chr6:150067640 NUP43 0.57 8.6 0.43 3.13e-16 Lung cancer; LUSC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg05347473 chr6:146136440 FBXO30 0.66 11.35 0.53 1.86e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg15147215 chr3:52552868 STAB1 -0.32 -6.4 -0.33 5.28e-10 Electroencephalogram traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25804072 chr2:10829725 NOL10 0.51 6.9 0.35 2.65e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg12639453 chr1:2035780 PRKCZ -0.31 -6.56 -0.34 2e-10 Height; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -6.49 -0.33 3.04e-10 Developmental language disorder (linguistic errors); LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg23102388 chr7:1867652 MAD1L1 -0.3 -5.68 -0.3 2.97e-8 Bipolar disorder and schizophrenia; LUSC trans rs11039798 0.764 rs10838882 chr11:48393035 T/A cg15704280 chr7:45808275 SEPT13 0.68 6.43 0.33 4.36e-10 Axial length; LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg04141948 chr7:1023156 CYP2W1 0.27 5.85 0.3 1.18e-8 Longevity;Endometriosis; LUSC cis rs10740039 0.732 rs10159808 chr10:62362190 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.73 -0.35 7.28e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7582180 0.676 rs6542940 chr2:100982144 A/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.56 -0.42 4.11e-16 Intelligence (multi-trait analysis); LUSC cis rs7582720 1.000 rs72932791 chr2:203700870 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11644478 chr21:40555479 PSMG1 -0.65 -10.18 -0.49 2.18e-21 Menarche (age at onset); LUSC trans rs7937682 0.881 rs4936678 chr11:111625085 C/T cg18187862 chr3:45730750 SACM1L -0.63 -7.56 -0.38 3.92e-13 Primary sclerosing cholangitis; LUSC cis rs9399401 0.961 rs9403383 chr6:142694049 G/A cg03128060 chr6:142623767 GPR126 0.34 6.16 0.32 2.1e-9 Chronic obstructive pulmonary disease; LUSC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg13206674 chr6:150067644 NUP43 0.6 9.5 0.46 4.09e-19 Lung cancer; LUSC cis rs8018808 0.935 rs760257 chr14:77935145 G/A cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg15839431 chr19:19639596 YJEFN3 -0.59 -6.06 -0.31 3.71e-9 Bipolar disorder; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg04234412 chr22:24373322 LOC391322 -0.85 -13.74 -0.6 2.21e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs965469 0.762 rs6515783 chr20:3245006 T/C cg25506879 chr20:3388711 C20orf194 -0.49 -5.67 -0.3 3.17e-8 IFN-related cytopenia; LUSC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg23711669 chr6:146136114 FBXO30 0.72 12.67 0.57 2.53e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs9814567 1.000 rs4368544 chr3:134300014 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3742264 0.656 rs9534263 chr13:46541450 C/T cg15192986 chr13:46630673 CPB2 -0.38 -5.82 -0.3 1.4e-8 Blood protein levels; LUSC cis rs7843479 1.000 rs1032094 chr8:21820479 A/T cg17168535 chr8:21777572 XPO7 0.68 10.52 0.5 1.46e-22 Mean corpuscular volume; LUSC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg08280861 chr8:58055591 NA -0.53 -5.89 -0.31 9.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs59698941 0.943 rs66685494 chr5:132291056 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs9300255 0.602 rs1716165 chr12:123648881 C/T cg00376283 chr12:123451042 ABCB9 0.67 8.42 0.42 1.1e-15 Neutrophil percentage of white cells; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.57 0.78 3.62e-69 Prudent dietary pattern; LUSC cis rs5758659 0.622 rs5758527 chr22:42375761 T/G cg04733989 chr22:42467013 NAGA 0.38 6.37 0.33 6.36e-10 Cognitive function; LUSC cis rs11623869 0.772 rs12587310 chr14:103907286 G/A cg24130564 chr14:104152367 KLC1 0.41 5.64 0.3 3.54e-8 Bone mineral density; LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg20295408 chr7:1910781 MAD1L1 -0.49 -6.92 -0.35 2.34e-11 Bipolar disorder and schizophrenia; LUSC cis rs6951245 0.882 rs10252404 chr7:1209607 C/A cg18402987 chr7:1209562 NA 0.74 7.99 0.4 2.18e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7824557 0.767 rs3808509 chr8:11163256 G/T cg06636001 chr8:8085503 FLJ10661 0.52 7.82 0.39 7.09e-14 Retinal vascular caliber; LUSC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg21028142 chr17:79581711 NPLOC4 0.34 7.98 0.4 2.39e-14 Eye color traits; LUSC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg09165964 chr15:75287851 SCAMP5 0.45 6.83 0.35 3.93e-11 Breast cancer; LUSC cis rs7582720 0.887 rs72934591 chr2:204019762 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 8.78 0.43 8.34e-17 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg10556349 chr10:835070 NA 0.57 6.44 0.33 4.19e-10 Eosinophil percentage of granulocytes; LUSC cis rs9378357 0.850 rs9391986 chr6:3290583 A/G cg08754725 chr6:3293098 SLC22A23 0.82 8.11 0.41 9.59e-15 Obesity-related traits; LUSC cis rs3858526 0.834 rs10838986 chr11:5977065 A/G cg25319279 chr11:5960081 NA -0.45 -6.32 -0.33 8.2e-10 DNA methylation (variation); LUSC cis rs7666738 0.546 rs17546687 chr4:98769266 T/A cg17366294 chr4:99064904 C4orf37 0.56 8.91 0.44 3.4e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg16132339 chr22:24313637 DDTL;DDT -0.41 -6.49 -0.33 3.18e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg18681998 chr4:17616180 MED28 0.87 16.17 0.66 7.54e-44 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11098499 0.954 rs10008392 chr4:120318839 G/A cg24375607 chr4:120327624 NA 0.78 11.34 0.53 2e-25 Corneal astigmatism; LUSC cis rs7617773 0.780 rs11706277 chr3:48360433 A/G cg20734569 chr3:48348370 SPINK8 -0.49 -7.82 -0.39 7.13e-14 Coronary artery disease; LUSC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg27432699 chr2:27873401 GPN1 -0.56 -8.37 -0.42 1.62e-15 Total body bone mineral density; LUSC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC trans rs45509595 0.841 rs200485 chr6:27775697 G/C cg01620082 chr3:125678407 NA -0.67 -6.9 -0.35 2.63e-11 Breast cancer; LUSC cis rs7267979 0.899 rs2104734 chr20:25526668 A/G cg03522245 chr20:25566470 NINL 0.37 5.96 0.31 6.4e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7953249 0.656 rs2243616 chr12:121406370 G/T cg02403541 chr12:121454288 C12orf43 -0.73 -11.4 -0.53 1.15e-25 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs11190604 1.000 rs2489046 chr10:102346282 A/C cg16342193 chr10:102329863 NA -0.35 -6.62 -0.34 1.4e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg03161606 chr19:29218774 NA 0.6 8.89 0.44 4.03e-17 Methadone dose in opioid dependence; LUSC cis rs9660992 0.649 rs12128254 chr1:205268097 C/T cg00857998 chr1:205179979 DSTYK 0.6 9.07 0.44 1.06e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs950169 0.922 rs62021167 chr15:85118051 T/A cg12863693 chr15:85201151 NMB 0.35 7.18 0.37 4.63e-12 Schizophrenia; LUSC cis rs9549367 0.756 rs3861723 chr13:113910926 A/G cg18105134 chr13:113819100 PROZ -0.63 -9.49 -0.46 4.38e-19 Platelet distribution width; LUSC cis rs2230307 0.536 rs834278 chr1:100510882 T/C cg24955406 chr1:100503596 HIAT1 0.57 6.15 0.32 2.23e-9 Carotid intima media thickness; LUSC cis rs9323205 1.000 rs7149022 chr14:51613980 A/C cg23942311 chr14:51606299 NA -0.49 -10.25 -0.49 1.24e-21 Cancer; LUSC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg19539972 chr4:7069911 GRPEL1 -0.72 -7.46 -0.38 7.61e-13 Monocyte percentage of white cells; LUSC cis rs7258465 0.563 rs10854166 chr19:18652844 A/G cg11102782 chr19:18549136 ISYNA1 0.31 5.78 0.3 1.71e-8 Breast cancer; LUSC cis rs1044826 1.000 rs3772877 chr3:139187626 C/G cg00490450 chr3:139108681 COPB2 0.52 6.68 0.34 1.03e-10 Obesity-related traits; LUSC cis rs6504340 0.739 rs1062037 chr17:46638154 T/C cg09704116 chr17:46666958 LOC404266 -0.36 -5.74 -0.3 2.15e-8 Primary tooth development (number of teeth); LUSC trans rs1728785 1.000 rs1170433 chr16:68606081 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs2692947 0.644 rs1030864 chr2:96822373 A/G cg23100626 chr2:96804247 ASTL 0.3 7.07 0.36 9.11e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.86e-12 Blood metabolite levels; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg16606324 chr3:10149918 C3orf24 0.6 8.13 0.41 8.64e-15 Alzheimer's disease; LUSC cis rs10193935 1.000 rs10185742 chr2:42429666 A/G cg27598129 chr2:42591480 NA -0.64 -8.64 -0.43 2.28e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.49 -0.38 6.15e-13 Aortic root size; LUSC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg21951975 chr1:209979733 IRF6 0.49 8.35 0.42 1.84e-15 Monobrow; LUSC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg06671706 chr8:8559999 CLDN23 0.48 6.6 0.34 1.66e-10 Obesity-related traits; LUSC cis rs9611519 0.780 rs3171692 chr22:41642212 C/T cg03806693 chr22:41940476 POLR3H -0.56 -8.13 -0.41 8.4e-15 Neuroticism; LUSC cis rs908922 0.742 rs499913 chr1:152476743 T/A cg20991723 chr1:152506922 NA 0.52 8.79 0.43 8.08e-17 Hair morphology; LUSC trans rs2762353 0.595 rs9467591 chr6:25742699 C/T cg18239417 chr7:154684963 DPP6 0.29 5.96 0.31 6.5e-9 Blood metabolite levels; LUSC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.67 -0.34 1.04e-10 Total body bone mineral density; LUSC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg05535760 chr7:792225 HEATR2 -0.78 -7.77 -0.39 1e-13 Cerebrospinal P-tau181p levels; LUSC cis rs9611565 0.649 rs5751144 chr22:42128097 A/G cg03806693 chr22:41940476 POLR3H -0.83 -12.3 -0.56 5.96e-29 Vitiligo; LUSC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs983392 0.836 rs7935829 chr11:59942815 A/G cg20284999 chr11:59952153 MS4A6A -0.38 -6.3 -0.33 9.48e-10 Alzheimer's disease (late onset); LUSC cis rs6087990 0.735 rs2424913 chr20:31374259 C/T cg13636640 chr20:31349939 DNMT3B 0.85 16.33 0.67 1.75e-44 Ulcerative colitis; LUSC cis rs295140 0.605 rs159320 chr2:201187775 A/G cg04283868 chr2:201171347 SPATS2L -0.42 -6.16 -0.32 2.03e-9 QT interval; LUSC cis rs8044995 0.563 rs8058517 chr16:68379860 A/G cg05110241 chr16:68378359 PRMT7 0.75 8.55 0.42 4.42e-16 Schizophrenia; LUSC cis rs6690583 0.697 rs2012369 chr1:85520845 T/C cg22153463 chr1:85462885 MCOLN2 -0.62 -8.01 -0.4 1.89e-14 Serum sulfate level; LUSC cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.39 0.33 5.53e-10 Rheumatoid arthritis; LUSC trans rs1005277 0.579 rs1780130 chr10:38485378 T/A cg17830980 chr10:43048298 ZNF37B -0.58 -9.33 -0.45 1.56e-18 Extrinsic epigenetic age acceleration; LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg21782813 chr7:2030301 MAD1L1 0.38 6.27 0.32 1.14e-9 Bipolar disorder and schizophrenia; LUSC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg06221963 chr1:154839813 KCNN3 -0.6 -13.52 -0.59 1.57e-33 Prostate cancer; LUSC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg08470875 chr2:26401718 FAM59B 0.69 8.96 0.44 2.27e-17 Gut microbiome composition (summer); LUSC cis rs6940638 0.615 rs9393801 chr6:27242681 A/G cg12292205 chr6:26970375 C6orf41 -0.41 -6.19 -0.32 1.78e-9 Intelligence (multi-trait analysis); LUSC trans rs4332037 0.539 rs55773130 chr7:2070554 T/C cg11693508 chr17:37793320 STARD3 0.51 6.12 0.32 2.69e-9 Bipolar disorder; LUSC cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg22782873 chr19:19639568 YJEFN3 -0.48 -5.75 -0.3 2.02e-8 Bipolar disorder; LUSC cis rs7923452 0.507 rs103441 chr10:30778184 C/T cg25182066 chr10:30743637 MAP3K8 -0.41 -5.82 -0.3 1.38e-8 Itch intensity from mosquito bite; LUSC cis rs6964587 1.000 rs3753109 chr7:91630001 G/C cg22709100 chr7:91322751 NA 0.39 5.84 0.3 1.23e-8 Breast cancer; LUSC cis rs10876993 0.928 rs1689586 chr12:58079586 A/T cg15848620 chr12:58087721 OS9 -0.57 -8.18 -0.41 5.81e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs9486719 1.000 rs13207333 chr6:96882254 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg17294928 chr15:75287854 SCAMP5 0.85 11.03 0.52 2.49e-24 Blood trace element (Zn levels); LUSC cis rs9513627 0.512 rs9517759 chr13:100180108 T/G cg25919922 chr13:100150906 NA 0.76 9.27 0.45 2.44e-18 Obesity-related traits; LUSC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg17971929 chr21:40555470 PSMG1 -0.51 -7.63 -0.39 2.48e-13 Menarche (age at onset); LUSC cis rs908922 0.584 rs71626721 chr1:152532745 A/G cg20991723 chr1:152506922 NA 0.47 8.71 0.43 1.42e-16 Hair morphology; LUSC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.11 -0.41 9.99e-15 Lung cancer; LUSC cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg16928487 chr17:17741425 SREBF1 -0.35 -6.84 -0.35 3.81e-11 Total body bone mineral density; LUSC cis rs2439831 0.867 rs496584 chr15:43831923 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.69 6.86 0.35 3.43e-11 Lung cancer in ever smokers; LUSC cis rs6580649 0.771 rs1635535 chr12:48386241 A/G cg24011408 chr12:48396354 COL2A1 0.49 6.07 0.32 3.52e-9 Lung cancer; LUSC cis rs9303401 0.659 rs62083362 chr17:56846464 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.71 0.6 3.09e-34 Cognitive test performance; LUSC cis rs4969178 0.965 rs16971105 chr17:76393975 G/T cg20026190 chr17:76395443 PGS1 0.45 8.08 0.4 1.22e-14 HDL cholesterol levels; LUSC trans rs9291683 0.620 rs4444830 chr4:10124819 A/G cg26043149 chr18:55253948 FECH -0.52 -7.7 -0.39 1.51e-13 Bone mineral density; LUSC cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg19875535 chr5:140030758 IK -0.54 -8.71 -0.43 1.43e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs7572644 0.766 rs13025314 chr2:28080214 G/A cg27432699 chr2:27873401 GPN1 0.51 6.47 0.33 3.46e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7683537 0.692 rs12509936 chr4:185662203 G/A cg04058563 chr4:185651563 MLF1IP 0.8 10.99 0.52 3.55e-24 Systemic lupus erythematosus; LUSC cis rs367943 0.672 rs1517207 chr5:112717245 G/A cg12552261 chr5:112820674 MCC 0.37 6.11 0.32 2.71e-9 Type 2 diabetes; LUSC cis rs10504073 0.609 rs17644494 chr8:50019679 T/C cg00325661 chr8:49890786 NA 0.62 10.33 0.49 6.65e-22 Blood metabolite ratios; LUSC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs354225 0.544 rs12713269 chr2:54809154 C/G cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs2013441 0.835 rs2526491 chr17:20097462 A/G cg04132472 chr17:19861366 AKAP10 -0.35 -5.65 -0.3 3.49e-8 Obesity-related traits; LUSC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg05802129 chr4:122689817 NA -0.36 -6.46 -0.33 3.63e-10 Type 2 diabetes; LUSC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.66 10.48 0.5 2.16e-22 Cognitive test performance; LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg09877947 chr5:131593287 PDLIM4 0.43 6.64 0.34 1.29e-10 Breast cancer; LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg10360139 chr7:1886902 MAD1L1 -0.45 -6.9 -0.35 2.7e-11 Bipolar disorder and schizophrenia; LUSC trans rs7615952 0.641 rs7618515 chr3:125790578 C/T cg07211511 chr3:129823064 LOC729375 -0.75 -9.74 -0.47 6.87e-20 Blood pressure (smoking interaction); LUSC cis rs11690935 1.000 rs3795999 chr2:172544483 A/G cg13550731 chr2:172543902 DYNC1I2 0.89 14.91 0.63 6.85e-39 Schizophrenia; LUSC cis rs5758511 0.508 rs2413667 chr22:42472237 A/C cg00645731 chr22:42541494 CYP2D7P1 0.52 8.01 0.4 1.94e-14 Birth weight; LUSC cis rs7833986 0.501 rs2667999 chr8:56950474 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.72 12.0 0.55 8.08e-28 Height; LUSC cis rs9902453 0.584 rs3809790 chr17:27955540 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.52 -7.68 -0.39 1.79e-13 Coffee consumption (cups per day); LUSC cis rs861020 0.630 rs585627 chr1:210004199 C/G cg05527609 chr1:210001259 C1orf107 0.7 10.07 0.48 5.22e-21 Orofacial clefts; LUSC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg03036452 chr22:46663545 TTC38 0.58 5.83 0.3 1.32e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs477692 1.000 rs522891 chr10:131430916 T/C cg26102564 chr10:131424627 MGMT -0.4 -6.19 -0.32 1.8e-9 Response to temozolomide; LUSC cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg18806716 chr10:30721971 MAP3K8 0.6 9.54 0.46 3.15e-19 Inflammatory bowel disease; LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.33e-19 Menopause (age at onset); LUSC cis rs9790314 0.846 rs9815222 chr3:160994897 C/T cg03342759 chr3:160939853 NMD3 -0.57 -9.78 -0.47 4.88e-20 Morning vs. evening chronotype; LUSC cis rs2204008 0.592 rs2320501 chr12:38145285 T/G cg26384229 chr12:38710491 ALG10B 0.86 14.29 0.62 1.8e-36 Bladder cancer; LUSC cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.71 10.56 0.5 1.09e-22 Chronic sinus infection; LUSC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg04455712 chr21:45112962 RRP1B 0.45 8.33 0.41 2.18e-15 Mean corpuscular volume; LUSC trans rs61931739 0.564 rs7304271 chr12:33757011 G/T cg26384229 chr12:38710491 ALG10B 0.43 6.24 0.32 1.3e-9 Morning vs. evening chronotype; LUSC cis rs936229 0.690 rs2445618 chr15:75035256 T/C cg14664628 chr15:75095509 CSK -0.85 -13.71 -0.6 2.94e-34 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs477692 1.000 rs477692 chr10:131426022 T/C cg26102564 chr10:131424627 MGMT 0.42 6.54 0.34 2.25e-10 Response to temozolomide; LUSC cis rs10927875 0.662 rs848309 chr1:16308447 T/C cg21385522 chr1:16154831 NA 0.58 9.0 0.44 1.78e-17 Dilated cardiomyopathy; LUSC cis rs2303282 0.716 rs4784667 chr16:56462000 G/A cg00500540 chr16:56394104 NA -0.43 -7.33 -0.37 1.75e-12 Breast cancer; LUSC cis rs11628318 0.614 rs10140498 chr14:103154191 A/G cg12046867 chr14:103022105 NA 0.42 5.81 0.3 1.48e-8 Platelet count; LUSC cis rs1670533 1.000 rs7679432 chr4:1050521 G/A cg02018176 chr4:1364513 KIAA1530 0.46 6.44 0.33 4.26e-10 Recombination rate (females); LUSC cis rs748404 0.697 rs473016 chr15:43558823 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.33 0.41 2.18e-15 Lung cancer; LUSC cis rs6580649 0.941 rs10492080 chr12:48501411 A/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.1 -0.32 2.9e-9 Lung cancer; LUSC cis rs8060686 0.920 rs73594556 chr16:67925435 G/A cg27539214 chr16:67997921 SLC12A4 -0.45 -5.9 -0.31 8.9e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs11039798 0.841 rs11500573 chr11:48713900 T/G cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC trans rs35110281 0.511 rs2298562 chr21:45085236 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.62 10.29 0.49 9.55e-22 Mean corpuscular volume; LUSC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg10523679 chr1:76189770 ACADM -0.84 -11.24 -0.52 4.63e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9549367 0.713 rs3024764 chr13:113824314 A/G cg18105134 chr13:113819100 PROZ -0.71 -10.47 -0.5 2.2e-22 Platelet distribution width; LUSC cis rs2439831 0.867 rs2245176 chr15:43750762 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC trans rs1941687 0.769 rs1493911 chr18:31356019 A/G cg27147174 chr7:100797783 AP1S1 -0.47 -6.97 -0.36 1.66e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs317689 0.959 rs317688 chr12:69726850 T/C cg11871910 chr12:69753446 YEATS4 0.55 7.14 0.36 5.86e-12 Response to diuretic therapy; LUSC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg26513180 chr16:89883248 FANCA -0.65 -10.46 -0.5 2.54e-22 Vitiligo; LUSC cis rs17270561 0.609 rs1165208 chr6:25803904 G/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.39 0.37 1.21e-12 Iron status biomarkers; LUSC cis rs6665290 0.669 rs3795446 chr1:227180981 C/T cg10327440 chr1:227177885 CDC42BPA 1.11 29.37 0.85 1.44e-94 Myeloid white cell count; LUSC cis rs34638657 0.872 rs2967352 chr16:82196676 T/C cg09439754 chr16:82129088 HSD17B2 -0.4 -6.1 -0.32 3.01e-9 Lung adenocarcinoma; LUSC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg05861140 chr6:150128134 PCMT1 -0.39 -5.89 -0.31 9.45e-9 Lung cancer; LUSC cis rs17539620 0.624 rs62432740 chr6:154836054 C/T cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC cis rs3768617 0.510 rs3818417 chr1:183079376 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.84 0.51 1.15e-23 Fuchs's corneal dystrophy; LUSC trans rs208520 0.661 rs4710566 chr6:66848538 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.91 -0.68 8.65e-47 Exhaled nitric oxide output; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg21304062 chr17:78075816 GAA 0.4 6.35 0.33 7.13e-10 Mosquito bite size; LUSC cis rs117623576 0.941 rs11008775 chr10:32410307 T/C cg03047570 chr10:32398778 NA -0.61 -6.61 -0.34 1.49e-10 Anti-saccade response; LUSC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg17948913 chr5:572064 NA 0.36 6.08 0.32 3.32e-9 Obesity-related traits; LUSC cis rs2710642 0.925 rs72807578 chr2:63008044 G/A cg17519650 chr2:63277830 OTX1 -0.51 -7.2 -0.37 3.97e-12 LDL cholesterol levels;LDL cholesterol; LUSC cis rs710216 0.843 rs10890232 chr1:43416514 C/T cg03128534 chr1:43423976 SLC2A1 0.51 6.6 0.34 1.61e-10 Red cell distribution width; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg09315468 chr8:38089562 DDHD2 -0.44 -6.59 -0.34 1.73e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs17102423 0.559 rs4899160 chr14:65481212 C/T cg11161011 chr14:65562177 MAX -0.69 -9.37 -0.46 1.1e-18 Obesity-related traits; LUSC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg06238570 chr21:40685208 BRWD1 0.49 7.51 0.38 5.59e-13 Cognitive function; LUSC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg03929089 chr4:120376271 NA -0.77 -12.25 -0.56 9.36e-29 Height; LUSC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.2e-12 Schizophrenia; LUSC cis rs2882667 0.690 rs160404 chr5:138084269 A/G cg04439458 chr5:138467593 SIL1 -0.33 -6.16 -0.32 2.14e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg03433033 chr1:76189801 ACADM 0.83 14.6 0.62 1.09e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg19592336 chr6:28129416 ZNF389 0.45 5.96 0.31 6.36e-9 Depression; LUSC trans rs7746199 0.736 rs17693963 chr6:27710165 A/C cg06606381 chr12:133084897 FBRSL1 -0.85 -8.07 -0.4 1.28e-14 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs7819412 0.875 rs6981523 chr8:11061792 C/T cg06636001 chr8:8085503 FLJ10661 -0.59 -8.8 -0.43 7.66e-17 Triglycerides; LUSC trans rs12579753 1.000 rs11519754 chr12:82209181 A/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.11 -0.32 2.81e-9 Resting heart rate; LUSC cis rs11792861 0.530 rs1772047 chr9:111679012 A/G cg05043794 chr9:111880884 C9orf5 0.31 6.84 0.35 3.78e-11 Menarche (age at onset); LUSC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg22655196 chr4:3374909 RGS12 0.3 5.91 0.31 8.28e-9 Serum sulfate level; LUSC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.64 0.63 8.06e-38 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6733011 0.628 rs4851163 chr2:99466664 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.68 -0.3 2.92e-8 Bipolar disorder; LUSC trans rs7507204 0.906 rs11671513 chr19:3429937 C/T cg08382705 chr11:45687319 CHST1 -0.54 -7.57 -0.38 3.71e-13 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09134682 chr17:17140493 FLCN 0.52 7.31 0.37 1.98e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7605827 0.930 rs6745731 chr2:15537915 C/T cg19274914 chr2:15703543 NA 0.46 8.98 0.44 2e-17 Educational attainment (years of education); LUSC cis rs11190604 0.945 rs7091356 chr10:102292268 G/C cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg16680214 chr1:154839983 KCNN3 -0.55 -10.58 -0.5 9.78e-23 Prostate cancer; LUSC cis rs9322817 0.691 rs9499954 chr6:105205826 C/T cg02098413 chr6:105308735 HACE1 -0.29 -5.91 -0.31 8.65e-9 Thyroid stimulating hormone; LUSC trans rs877282 0.755 rs2790388 chr10:786084 T/C cg13042288 chr15:90349979 ANPEP -0.41 -6.23 -0.32 1.43e-9 Uric acid levels; LUSC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg19077165 chr18:44547161 KATNAL2 -0.39 -5.77 -0.3 1.79e-8 Personality dimensions; LUSC cis rs4730250 0.708 rs4730242 chr7:107057373 G/C cg02696742 chr7:106810147 HBP1 -0.65 -9.32 -0.45 1.62e-18 Osteoarthritis; LUSC cis rs7264396 0.623 rs761827 chr20:34207897 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -7.15 -0.36 5.4e-12 Total cholesterol levels; LUSC cis rs9549367 0.789 rs2287248 chr13:113889226 T/C cg18105134 chr13:113819100 PROZ -0.67 -9.47 -0.46 5.48e-19 Platelet distribution width; LUSC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg04553112 chr3:125709451 NA -0.51 -5.78 -0.3 1.76e-8 Blood pressure (smoking interaction); LUSC cis rs12712135 0.706 rs6543114 chr2:102925994 A/C cg20060108 chr2:102954350 IL1RL1 0.38 5.76 0.3 1.95e-8 Blood protein levels; LUSC cis rs2522056 0.808 rs7704457 chr5:131744790 C/T cg24060327 chr5:131705240 SLC22A5 -0.46 -6.37 -0.33 6.36e-10 Lymphocyte counts;Fibrinogen; LUSC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg18827107 chr12:86230957 RASSF9 -0.44 -6.61 -0.34 1.48e-10 Major depressive disorder; LUSC cis rs27434 0.583 rs151911 chr5:96157084 A/G cg16492584 chr5:96139282 ERAP1 -0.56 -7.57 -0.38 3.61e-13 Ankylosing spondylitis; LUSC cis rs4595586 0.505 rs11611321 chr12:39390803 C/T cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg21132104 chr15:45694354 SPATA5L1 0.57 8.13 0.41 8.21e-15 Homoarginine levels; LUSC cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.32 -0.41 2.25e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg17143192 chr8:8559678 CLDN23 -0.61 -8.98 -0.44 1.99e-17 Obesity-related traits; LUSC trans rs12196849 0.668 rs1078326 chr6:98785243 C/T cg04408923 chr7:5464875 NA -0.36 -6.01 -0.31 4.73e-9 Intelligence (multi-trait analysis); LUSC cis rs977987 0.806 rs12444589 chr16:75454404 A/T cg03315344 chr16:75512273 CHST6 -0.49 -9.2 -0.45 4.13e-18 Dupuytren's disease; LUSC cis rs17401966 0.931 rs17410217 chr1:10371854 A/G cg19773385 chr1:10388646 KIF1B -0.59 -9.76 -0.47 5.95e-20 Hepatocellular carcinoma; LUSC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg00033643 chr7:134001901 SLC35B4 0.44 6.83 0.35 4.02e-11 Mean platelet volume; LUSC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg12365402 chr11:9010492 NRIP3 0.48 8.99 0.44 1.91e-17 Hemoglobin concentration; LUSC cis rs847577 0.609 rs11765552 chr7:97822115 T/A cg21770322 chr7:97807741 LMTK2 0.56 10.08 0.48 4.99e-21 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06577708 chr3:64008893 PSMD6 0.44 6.59 0.34 1.75e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg24642439 chr20:33292090 TP53INP2 0.56 8.3 0.41 2.62e-15 Height; LUSC cis rs12421382 0.543 rs10890996 chr11:109328421 A/G cg27471124 chr11:109292789 C11orf87 -0.55 -9.81 -0.47 4.02e-20 Schizophrenia; LUSC cis rs36051895 0.588 rs12340895 chr9:5076691 C/G cg02405213 chr9:5042618 JAK2 0.66 9.7 0.47 9.03e-20 Pediatric autoimmune diseases; LUSC trans rs8073060 0.592 rs225306 chr17:33920036 A/C cg19694781 chr19:47549865 TMEM160 0.74 11.82 0.54 3.67e-27 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs12579753 1.000 rs34894912 chr12:82228721 A/G cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs10743315 0.557 rs16915323 chr12:19437529 A/G cg02471346 chr12:19282374 PLEKHA5 0.79 6.08 0.32 3.29e-9 Gut microbiota (bacterial taxa); LUSC cis rs35000415 0.938 rs34381587 chr7:128666825 A/G cg19972273 chr7:128594194 NA 0.68 6.9 0.35 2.56e-11 Systemic lupus erythematosus; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg12419862 chr22:24373484 LOC391322 -0.84 -13.65 -0.6 5.34e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg24675056 chr1:15929824 NA 0.48 8.33 0.41 2.17e-15 Systolic blood pressure; LUSC cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg08085267 chr17:45401833 C17orf57 0.54 8.69 0.43 1.65e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1371867 0.846 rs1788182 chr8:101334620 C/T cg00191853 chr8:101177733 SPAG1 -0.39 -6.47 -0.33 3.49e-10 Atrioventricular conduction; LUSC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.7 0.34 8.67e-11 Menarche (age at onset); LUSC cis rs453301 0.653 rs7005133 chr8:8901222 T/G cg15556689 chr8:8085844 FLJ10661 0.68 10.81 0.51 1.44e-23 Joint mobility (Beighton score); LUSC cis rs12421382 0.881 rs1808843 chr11:109389471 A/G cg27471124 chr11:109292789 C11orf87 0.49 8.99 0.44 1.84e-17 Schizophrenia; LUSC cis rs7980687 0.596 rs1727319 chr12:123701353 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.43 -0.33 4.31e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs868036 0.681 rs28626095 chr15:68066729 T/C cg05925327 chr15:68127851 NA -0.39 -6.36 -0.33 6.68e-10 Restless legs syndrome; LUSC cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs11690935 0.959 rs6724337 chr2:172735329 C/T cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.68 -0.63 5.34e-38 Schizophrenia; LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 7.85e-17 Bipolar disorder; LUSC cis rs2486288 0.656 rs11629858 chr15:45547114 T/C cg26924012 chr15:45694286 SPATA5L1 -0.7 -9.99 -0.48 9.74e-21 Glomerular filtration rate; LUSC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg26314531 chr2:26401878 FAM59B -0.68 -9.13 -0.45 6.62e-18 Gut microbiome composition (summer); LUSC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg21984481 chr17:79567631 NPLOC4 -0.72 -15.22 -0.64 4.16e-40 Eye color traits; LUSC cis rs3092073 0.603 rs4810477 chr20:44544654 C/T cg27529037 chr20:44575021 PCIF1 0.37 6.43 0.33 4.44e-10 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.966 rs11010102 chr10:35411066 T/A cg04310649 chr10:35416472 CREM -0.43 -6.86 -0.35 3.34e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg02951883 chr7:2050386 MAD1L1 -0.57 -10.3 -0.49 8.78e-22 Bipolar disorder and schizophrenia; LUSC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg13683864 chr3:40499215 RPL14 -0.95 -16.24 -0.66 3.94e-44 Renal cell carcinoma; LUSC cis rs55675132 0.667 rs2798471 chr1:115634898 T/C cg01522456 chr1:115632236 TSPAN2 0.47 6.52 0.34 2.53e-10 Schizophrenia; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg10802521 chr3:52805072 NEK4 -0.46 -7.09 -0.36 7.94e-12 Electroencephalogram traits; LUSC cis rs2486288 0.656 rs6493143 chr15:45570781 G/T cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.42e-10 Glomerular filtration rate; LUSC cis rs77106637 1.000 rs3862791 chr11:72501002 C/T cg04827223 chr11:72435913 ARAP1 -0.73 -9.23 -0.45 3.17e-18 Type 2 diabetes; LUSC cis rs2274273 0.662 rs4525413 chr14:55661138 A/T cg04306507 chr14:55594613 LGALS3 0.47 9.48 0.46 5e-19 Protein biomarker; LUSC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.04e-11 Glomerular filtration rate (creatinine); LUSC cis rs17155006 0.664 rs401487 chr7:107743409 A/G cg05962710 chr7:107745446 LAMB4 -0.33 -5.82 -0.3 1.4e-8 Pneumococcal bacteremia; LUSC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs708547 0.647 rs2293175 chr4:57861358 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.8 -0.3 1.52e-8 Response to bleomycin (chromatid breaks); LUSC cis rs7202877 0.656 rs977986 chr16:75506696 T/G cg03315344 chr16:75512273 CHST6 0.42 5.99 0.31 5.55e-9 Type 2 diabetes;Type 1 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25183470 chr7:39605805 C7orf36 -0.4 -6.08 -0.32 3.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1577917 0.771 rs2758847 chr6:86349103 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.01 -0.52 2.95e-24 Response to antipsychotic treatment; LUSC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.8 10.37 0.49 4.87e-22 Schizophrenia; LUSC cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg02527881 chr3:46936655 PTH1R -0.39 -6.87 -0.35 3.2e-11 Colorectal cancer; LUSC cis rs6545883 0.929 rs1838978 chr2:61540923 T/C cg15711740 chr2:61764176 XPO1 0.48 7.51 0.38 5.4e-13 Tuberculosis; LUSC cis rs2464469 0.654 rs2067062 chr15:58341954 T/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.97 -0.31 6.04e-9 Barrett's esophagus or Esophageal adenocarcinoma; LUSC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg00376283 chr12:123451042 ABCB9 0.81 12.38 0.56 3.16e-29 Platelet count; LUSC cis rs6964587 0.967 rs12538325 chr7:91757479 A/G cg22709100 chr7:91322751 NA 0.41 5.88 0.31 1.01e-8 Breast cancer; LUSC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.47 -7.58 -0.38 3.33e-13 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg00945038 chr17:61921165 SMARCD2 0.53 9.43 0.46 7.01e-19 Prudent dietary pattern; LUSC cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg26384229 chr12:38710491 ALG10B 0.96 17.69 0.7 7.15e-50 Heart rate; LUSC cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg15073853 chr19:18549131 ISYNA1 -0.32 -5.8 -0.3 1.52e-8 Breast cancer; LUSC cis rs12681287 0.640 rs4490816 chr8:87384938 T/C cg00550725 chr8:87521180 FAM82B -0.43 -5.71 -0.3 2.51e-8 Caudate activity during reward; LUSC cis rs1505368 0.534 rs10185241 chr2:213244124 C/T cg16329650 chr2:213403929 ERBB4 0.45 7.21 0.37 3.83e-12 Symmetrical dimethylarginine levels; LUSC cis rs73200209 0.744 rs11615689 chr12:116699675 T/C cg01776926 chr12:116560359 MED13L -0.48 -5.8 -0.3 1.53e-8 Total body bone mineral density; LUSC cis rs6681460 1.000 rs9662962 chr1:67121364 C/T cg02459107 chr1:67143332 SGIP1 0.47 8.94 0.44 2.71e-17 Presence of antiphospholipid antibodies; LUSC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg15704280 chr7:45808275 SEPT13 1.03 17.61 0.69 1.42e-49 Coronary artery disease; LUSC trans rs6601327 0.641 rs9644704 chr8:9560169 A/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.52 -0.34 2.6e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs72772090 0.539 rs11746534 chr5:96124807 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.96 -0.36 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg22029157 chr1:209979665 IRF6 0.77 10.03 0.48 7.39e-21 Cleft lip with or without cleft palate; LUSC cis rs870825 0.860 rs2696044 chr4:185595988 C/G cg04058563 chr4:185651563 MLF1IP 0.79 11.48 0.53 5.96e-26 Blood protein levels; LUSC cis rs6722750 0.840 rs6712700 chr2:64374041 A/G cg22352474 chr2:64371530 PELI1 0.68 10.91 0.51 6.4e-24 Neuroticism; LUSC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg14440974 chr22:39074834 NA -0.34 -5.69 -0.3 2.76e-8 Menopause (age at onset); LUSC cis rs7903847 0.642 rs10882908 chr10:99134970 T/C cg06359132 chr10:99160096 RRP12 -0.24 -5.65 -0.3 3.39e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg22875332 chr1:76189707 ACADM -0.74 -10.34 -0.49 6.33e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10791097 1.000 rs10791097 chr11:130718630 G/T cg12179176 chr11:130786555 SNX19 -0.76 -12.73 -0.57 1.5e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs1443512 0.773 rs2366149 chr12:54347698 T/G cg17410650 chr12:54324560 NA -0.47 -7.36 -0.37 1.41e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg20503657 chr10:835505 NA -0.96 -13.38 -0.59 5.37e-33 Eosinophil percentage of granulocytes; LUSC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg16383222 chr8:145688536 CYHR1 0.34 5.83 0.3 1.31e-8 Age at first birth; LUSC cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg12310025 chr6:25882481 NA -0.5 -9.09 -0.45 8.78e-18 Blood metabolite levels; LUSC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.79 0.47 4.77e-20 Personality dimensions; LUSC cis rs6964587 0.839 rs62466809 chr7:91472801 A/G cg22709100 chr7:91322751 NA 0.46 6.84 0.35 3.89e-11 Breast cancer; LUSC cis rs9517320 0.534 rs912330 chr13:99131294 C/T cg07423050 chr13:99094983 FARP1 -0.52 -9.5 -0.46 4.31e-19 Longevity; LUSC cis rs644799 0.710 rs473852 chr11:95568757 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.82 12.56 0.57 7.01e-30 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg14019146 chr3:50243930 SLC38A3 -0.36 -8.07 -0.4 1.31e-14 Body mass index; LUSC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.52 -0.53 4.54e-26 Schizophrenia; LUSC cis rs7572644 0.713 rs35841453 chr2:28072702 T/C cg27432699 chr2:27873401 GPN1 0.52 6.62 0.34 1.45e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2370759 1.000 rs11008865 chr10:32574842 C/T cg01819863 chr10:32635814 EPC1 1.08 13.45 0.59 2.87e-33 Sexual dysfunction (female); LUSC cis rs11229555 0.574 rs11603800 chr11:58202085 A/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.46 8.88 0.44 4.09e-17 Monocyte percentage of white cells; LUSC cis rs601339 1.000 rs2454722 chr12:123171218 A/G cg11919336 chr12:123188078 GPR109A 0.4 5.94 0.31 7.13e-9 Adiponectin levels; LUSC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg12639453 chr1:2035780 PRKCZ -0.31 -6.6 -0.34 1.58e-10 Height; LUSC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 13.63 0.6 6.23e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1595825 0.891 rs73054817 chr2:198623751 A/G cg00982548 chr2:198649783 BOLL -0.58 -7.21 -0.37 3.87e-12 Ulcerative colitis; LUSC cis rs8031584 0.918 rs35396566 chr15:31263057 T/C cg08704250 chr15:31115839 NA -0.56 -8.1 -0.41 1.03e-14 Huntington's disease progression; LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.56 0.57 6.99e-30 Prudent dietary pattern; LUSC cis rs4704187 0.687 rs6453111 chr5:74379926 C/T cg03227963 chr5:74354835 NA 0.31 6.73 0.35 7.4e-11 Response to amphetamines; LUSC cis rs2315504 1.000 rs2524306 chr17:39035811 G/A cg17985300 chr17:38952333 KRT28 -0.35 -7.12 -0.36 6.56e-12 Height; LUSC cis rs10464366 0.510 rs62442212 chr7:39146896 A/C cg10621924 chr7:39171070 POU6F2 0.46 7.32 0.37 1.9e-12 IgG glycosylation; LUSC cis rs9309473 0.848 rs17009159 chr2:73797762 A/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.53 -0.34 2.47e-10 Metabolite levels; LUSC cis rs10740039 0.516 rs1938546 chr10:62315986 G/A cg18175470 chr10:62150864 ANK3 -0.47 -6.94 -0.36 2.01e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg03609598 chr5:56110824 MAP3K1 -0.41 -6.05 -0.31 3.78e-9 Initial pursuit acceleration; LUSC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg20203395 chr5:56204925 C5orf35 -0.46 -6.79 -0.35 5e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs7824557 0.524 rs7835318 chr8:10953874 G/A cg27411982 chr8:10470053 RP1L1 -0.39 -6.42 -0.33 4.69e-10 Retinal vascular caliber; LUSC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7923609 0.838 rs7909960 chr10:65239177 T/A cg01631684 chr10:65280961 REEP3 -0.41 -6.26 -0.32 1.19e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9291683 0.588 rs13121211 chr4:9999539 A/G cg11266682 chr4:10021025 SLC2A9 0.56 10.08 0.48 4.91e-21 Bone mineral density; LUSC cis rs7107174 0.901 rs10899473 chr11:78042983 A/C cg02023728 chr11:77925099 USP35 0.46 7.01 0.36 1.34e-11 Testicular germ cell tumor; LUSC cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg23711669 chr6:146136114 FBXO30 0.83 14.64 0.63 7.86e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.45 -0.42 9.1e-16 Axial length; LUSC cis rs4594175 0.962 rs8008182 chr14:51608357 C/T cg23942311 chr14:51606299 NA 0.3 5.73 0.3 2.23e-8 Cancer; LUSC cis rs7927771 0.524 rs10742824 chr11:47864842 C/T cg20307385 chr11:47447363 PSMC3 0.46 6.77 0.35 5.93e-11 Subjective well-being; LUSC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.11 0.36 6.98e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs73206853 0.563 rs57488849 chr12:111181785 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.13 0.36 6.19e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs78366141 0.649 rs112818517 chr4:89653103 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.95 7.1 0.36 7.53e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.89 -0.31 9.18e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg00339695 chr16:24857497 SLC5A11 0.6 8.87 0.44 4.51e-17 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg07212818 chr11:638076 DRD4 -0.38 -6.51 -0.34 2.79e-10 Systemic lupus erythematosus; LUSC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg11632617 chr15:75315747 PPCDC -0.52 -6.78 -0.35 5.39e-11 Blood trace element (Zn levels); LUSC cis rs559928 0.606 rs11605856 chr11:63925528 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 7.11 0.36 7.16e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs1178968 0.688 rs6951676 chr7:72753243 C/T cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.84e-13 Triglyceride levels; LUSC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.74 -12.92 -0.58 3.05e-31 Total body bone mineral density; LUSC cis rs1371867 0.846 rs1616833 chr8:101271821 C/T cg00191853 chr8:101177733 SPAG1 0.34 5.78 0.3 1.74e-8 Atrioventricular conduction; LUSC cis rs6714788 0.565 rs7558817 chr2:100654482 C/A cg22139774 chr2:100720529 AFF3 -0.38 -6.04 -0.31 4.2e-9 Intelligence (multi-trait analysis); LUSC cis rs10782582 0.593 rs12131493 chr1:76139172 G/A cg03433033 chr1:76189801 ACADM -0.45 -6.74 -0.35 7.09e-11 Daytime sleep phenotypes; LUSC cis rs3845702 0.736 rs56401468 chr2:180857757 C/T cg01881094 chr2:180872142 CWC22 1.05 12.34 0.56 4.29e-29 Schizophrenia; LUSC cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.99 0.31 5.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs41271473 0.898 rs55730631 chr1:228865663 C/A cg16512390 chr1:228756714 NA 0.53 6.22 0.32 1.5e-9 Chronic lymphocytic leukemia; LUSC cis rs9788682 0.642 rs2568483 chr15:78752343 A/G cg06917634 chr15:78832804 PSMA4 -0.47 -5.95 -0.31 6.63e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg23887609 chr12:130822674 PIWIL1 0.49 7.34 0.37 1.64e-12 Menopause (age at onset); LUSC cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.67 0.43 1.96e-16 Motion sickness; LUSC cis rs367615 0.679 rs10070786 chr5:108815081 T/G cg17395555 chr5:108820864 NA 0.62 11.23 0.52 4.82e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs2731664 0.792 rs2544809 chr5:176885499 T/C cg23176889 chr5:176863531 GRK6 -0.65 -13.03 -0.58 1.17e-31 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.817 rs11040474 chr11:49708441 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.19 -0.8 2.08e-75 Height; LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg12963246 chr6:28129442 ZNF389 0.58 8.07 0.4 1.24e-14 Parkinson's disease; LUSC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.35 6.85 0.35 3.5e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg09367891 chr1:107599246 PRMT6 -0.54 -8.57 -0.42 3.84e-16 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7075426 0.669 rs11202042 chr10:88237104 T/C cg07322936 chr10:88137208 NA 0.46 6.57 0.34 1.9e-10 Migraine without aura; LUSC cis rs912057 0.833 rs1294421 chr6:6743149 A/C cg06612196 chr6:6737390 NA 0.55 10.66 0.5 4.93e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC trans rs1814175 0.765 rs1721990 chr11:49912154 G/C cg03929089 chr4:120376271 NA -1.04 -20.04 -0.74 3.08e-59 Height; LUSC cis rs1371867 0.846 rs1660353 chr8:101250907 C/T cg06002616 chr8:101225028 SPAG1 0.39 6.62 0.34 1.41e-10 Atrioventricular conduction; LUSC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.81e-12 Depression; LUSC cis rs7264396 0.563 rs6060580 chr20:34310512 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.61 -0.43 2.97e-16 Total cholesterol levels; LUSC cis rs10992471 0.756 rs10123342 chr9:95087824 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.49 -8.25 -0.41 3.72e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.89 0.66 9.59e-43 Bladder cancer; LUSC cis rs73206853 0.841 rs56251637 chr12:110833869 T/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1775715 0.769 rs2799030 chr10:32172935 G/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.84 0.39 6.07e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7777754 0.512 rs3757472 chr7:50537983 A/C cg18232548 chr7:50535776 DDC -0.7 -11.0 -0.52 3.07e-24 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC trans rs9987353 0.830 rs4841114 chr8:9129698 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -5.99 -0.31 5.44e-9 Recombination measurement; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02801482 chr2:159824941 TANC1 -0.5 -5.98 -0.31 5.72e-9 Bipolar disorder and schizophrenia; LUSC trans rs8073060 0.586 rs6505487 chr17:33996850 A/G cg19694781 chr19:47549865 TMEM160 -1.1 -17.39 -0.69 1.1e-48 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs9399135 1.000 rs4896130 chr6:135355118 C/T cg22676075 chr6:135203613 NA 0.48 7.41 0.38 1.02e-12 Red blood cell count; LUSC cis rs12908161 1.000 rs35726233 chr15:85337800 C/T cg12863693 chr15:85201151 NMB 0.39 8.1 0.41 1.07e-14 Schizophrenia; LUSC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg19257562 chr1:2043853 PRKCZ 0.31 6.15 0.32 2.19e-9 Height; LUSC cis rs2777491 0.957 rs316614 chr15:41746625 A/G cg18705301 chr15:41695430 NDUFAF1 -0.71 -12.85 -0.58 5.32e-31 Ulcerative colitis; LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg22907277 chr7:1156413 C7orf50 0.45 6.82 0.35 4.19e-11 Longevity;Endometriosis; LUSC cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.38 0.49 4.76e-22 Schizophrenia; LUSC cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg03146154 chr1:46216737 IPP 0.51 7.74 0.39 1.21e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8017423 0.874 rs4900029 chr14:90686257 T/A cg04374321 chr14:90722782 PSMC1 0.72 11.32 0.53 2.26e-25 Mortality in heart failure; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg22907277 chr7:1156413 C7orf50 -0.58 -9.15 -0.45 5.77e-18 Longevity;Endometriosis; LUSC cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg03264133 chr6:25882463 NA -0.34 -5.68 -0.3 2.9e-8 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01430372 chr17:38976870 TMEM99;KRT10 0.41 6.1 0.32 3.01e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13315871 0.929 rs1554124 chr3:58268968 C/G cg12435725 chr3:58293450 RPP14 -0.71 -7.53 -0.38 4.8e-13 Cholesterol, total; LUSC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg00101154 chr16:420108 MRPL28 -0.38 -5.76 -0.3 1.91e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs10782582 0.609 rs79835994 chr1:76287508 G/T cg03433033 chr1:76189801 ACADM -0.43 -6.21 -0.32 1.59e-9 Daytime sleep phenotypes; LUSC cis rs7727544 0.716 rs7701414 chr5:131585958 A/G cg24060327 chr5:131705240 SLC22A5 -0.4 -6.62 -0.34 1.45e-10 Blood metabolite levels; LUSC cis rs950776 0.518 rs3813571 chr15:78832792 G/T cg22563815 chr15:78856949 CHRNA5 0.26 6.34 0.33 7.29e-10 Sudden cardiac arrest; LUSC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg05861140 chr6:150128134 PCMT1 -0.38 -6.04 -0.31 4.07e-9 Lung cancer; LUSC cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg19717773 chr7:2847554 GNA12 -0.39 -6.07 -0.32 3.47e-9 Height; LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.79 -0.57 9.28e-31 Platelet count; LUSC cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg18721089 chr20:30220636 NA -0.35 -6.01 -0.31 4.78e-9 Mean corpuscular hemoglobin; LUSC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg22875332 chr1:76189707 ACADM -0.77 -10.41 -0.5 3.55e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg01416388 chr22:39784598 NA 0.45 7.55 0.38 4.23e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9790314 1.000 rs7647327 chr3:161016421 T/C cg04691961 chr3:161091175 C3orf57 -0.34 -5.9 -0.31 9.03e-9 Morning vs. evening chronotype; LUSC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg22467129 chr15:76604101 ETFA -0.44 -7.0 -0.36 1.43e-11 Blood metabolite levels; LUSC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg22800045 chr5:56110881 MAP3K1 0.75 9.64 0.47 1.46e-19 Initial pursuit acceleration; LUSC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg25427524 chr10:38739819 LOC399744 -0.58 -10.36 -0.49 5.28e-22 Extrinsic epigenetic age acceleration; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22442454 chr1:209979470 IRF6 0.7 13.06 0.58 9.15e-32 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs9329221 0.506 rs6993610 chr8:10330994 C/G cg27411982 chr8:10470053 RP1L1 -0.48 -7.24 -0.37 3.06e-12 Neuroticism; LUSC cis rs12545109 0.842 rs2582379 chr8:57395243 C/T cg09654669 chr8:57350985 NA 0.46 5.8 0.3 1.56e-8 Obesity-related traits; LUSC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg03388025 chr16:89894329 SPIRE2 -0.31 -5.88 -0.31 1.01e-8 Vitiligo; LUSC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg24675658 chr1:53192096 ZYG11B -0.65 -10.35 -0.49 5.78e-22 Monocyte count; LUSC cis rs17401966 1.000 rs2229687 chr1:10473196 C/T cg19773385 chr1:10388646 KIF1B -0.57 -9.61 -0.47 1.81e-19 Hepatocellular carcinoma; LUSC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg23643435 chr2:38893251 GALM -0.66 -6.96 -0.36 1.76e-11 5-HTT brain serotonin transporter levels; LUSC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg21535247 chr6:8435926 SLC35B3 0.58 8.91 0.44 3.31e-17 Motion sickness; LUSC cis rs477692 0.905 rs508360 chr10:131424969 A/G cg11019008 chr10:131425282 MGMT 0.41 6.29 0.33 9.83e-10 Response to temozolomide; LUSC cis rs3755132 0.929 rs6746074 chr2:15743816 G/A cg12888861 chr2:15731646 DDX1 0.5 7.3 0.37 2.16e-12 Wilms tumor; LUSC trans rs9393777 0.841 rs34332556 chr6:27357414 C/G cg06606381 chr12:133084897 FBRSL1 -0.99 -8.82 -0.43 6.37e-17 Intelligence (multi-trait analysis); LUSC trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg03929089 chr4:120376271 NA -0.58 -7.09 -0.36 7.87e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs2439831 0.717 rs10518820 chr15:43888976 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.59 0.43 3.37e-16 Lung cancer in ever smokers; LUSC cis rs11971779 0.590 rs4732374 chr7:139091453 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7582720 1.000 rs72934514 chr2:203933339 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 8.72 0.43 1.37e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg10523679 chr1:76189770 ACADM 0.9 16.45 0.67 5.98e-45 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8017423 0.933 rs7150378 chr14:90724566 G/A cg04374321 chr14:90722782 PSMC1 0.76 12.18 0.55 1.7e-28 Mortality in heart failure; LUSC cis rs3820928 0.874 rs1320407 chr2:227867385 G/T cg11843606 chr2:227700838 RHBDD1 -0.49 -7.13 -0.36 6.22e-12 Pulmonary function; LUSC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg12463550 chr7:65579703 CRCP -0.55 -8.19 -0.41 5.77e-15 Aortic root size; LUSC cis rs8060686 0.565 rs55857142 chr16:68236741 A/T cg04539111 chr16:67997858 SLC12A4 -0.48 -6.18 -0.32 1.91e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs796825 0.530 rs56103727 chr3:119986843 G/A cg21790991 chr3:120137480 FSTL1 -0.34 -6.1 -0.32 2.93e-9 HIV-1 susceptibility; LUSC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.58 -11.4 -0.53 1.24e-25 Monocyte percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02222290 chr10:72575603 SGPL1 -0.43 -6.15 -0.32 2.16e-9 Electrocardiographic conduction measures; LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg16434002 chr17:42200994 HDAC5 0.46 6.74 0.35 7.02e-11 Total body bone mineral density; LUSC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg04287289 chr16:89883240 FANCA -0.73 -6.12 -0.32 2.65e-9 Skin colour saturation; LUSC cis rs1448094 1.000 rs10083080 chr12:86348579 G/C cg00310523 chr12:86230176 RASSF9 0.36 6.56 0.34 2.1e-10 Major depressive disorder; LUSC cis rs6938 0.563 rs12917376 chr15:75116167 C/T cg14664628 chr15:75095509 CSK -0.64 -10.01 -0.48 8.52e-21 Breast cancer; LUSC cis rs1113500 0.933 rs4593854 chr1:108638519 A/G cg11967332 chr1:108735228 SLC25A24 0.4 6.11 0.32 2.77e-9 Growth-regulated protein alpha levels; LUSC cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg01943577 chr7:158741284 NA -0.4 -5.72 -0.3 2.37e-8 Height; LUSC cis rs4400599 0.594 rs7526644 chr1:154208753 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.35 -5.7 -0.3 2.61e-8 Platelet distribution width; LUSC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg06481639 chr22:41940642 POLR3H -0.54 -5.97 -0.31 6.16e-9 Vitiligo; LUSC cis rs765787 0.530 rs1706830 chr15:45516229 G/A cg25801113 chr15:45476975 SHF 0.34 7.0 0.36 1.37e-11 Uric acid levels; LUSC cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs701145 0.730 rs2666192 chr3:154004009 T/C cg17054900 chr3:154042577 DHX36 0.84 8.49 0.42 6.84e-16 Coronary artery disease; LUSC cis rs738321 0.756 rs4821740 chr22:38514423 C/G cg25457927 chr22:38595422 NA -0.32 -6.01 -0.31 4.8e-9 Breast cancer; LUSC cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.92 0.4 3.59e-14 Colorectal cancer; LUSC cis rs427941 0.632 rs201498 chr7:101756262 G/A cg06246474 chr7:101738831 CUX1 0.39 6.32 0.33 8.36e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7582180 0.614 rs4850931 chr2:101005145 C/T cg08017756 chr2:100939284 LONRF2 -0.43 -8.14 -0.41 8.07e-15 Intelligence (multi-trait analysis); LUSC cis rs62458065 1.000 rs10231294 chr7:32465357 C/T cg20159608 chr7:32802032 NA -0.57 -7.01 -0.36 1.34e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg04455712 chr21:45112962 RRP1B 0.46 8.38 0.42 1.51e-15 Mean corpuscular volume; LUSC trans rs10506458 0.915 rs998506 chr12:63400017 C/T cg22491629 chr6:157744540 C6orf35 -0.89 -10.89 -0.51 7.48e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs9921338 0.961 rs7199821 chr16:11425011 T/G cg00044050 chr16:11439710 C16orf75 -0.5 -6.64 -0.34 1.3e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg05472934 chr7:22766657 IL6 0.4 6.16 0.32 2.08e-9 Lung cancer; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg19747945 chr6:42946146 PEX6 -0.34 -5.67 -0.3 3.11e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg14789911 chr21:47582049 C21orf56 -0.37 -5.65 -0.3 3.42e-8 Testicular germ cell tumor; LUSC cis rs1577917 0.839 rs9450333 chr6:86519755 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -6.31 -0.33 8.61e-10 Response to antipsychotic treatment; LUSC trans rs3733585 0.699 rs7437120 chr4:9967683 T/A cg26043149 chr18:55253948 FECH -0.46 -7.09 -0.36 7.93e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg06873352 chr17:61820015 STRADA 0.7 12.65 0.57 3.11e-30 Prudent dietary pattern; LUSC cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg15423357 chr2:25149977 NA 0.45 9.09 0.45 8.9e-18 Body mass index; LUSC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg18230493 chr5:56204884 C5orf35 -0.57 -8.95 -0.44 2.48e-17 Coronary artery disease; LUSC cis rs7584330 0.666 rs7600317 chr2:238353513 C/T cg16989719 chr2:238392110 NA -0.41 -6.77 -0.35 5.98e-11 Prostate cancer; LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg08859206 chr1:53392774 SCP2 0.51 8.74 0.43 1.14e-16 Monocyte count; LUSC cis rs6582630 0.576 rs4403871 chr12:38292193 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.91 -0.35 2.44e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs3820068 0.603 rs7516453 chr1:15972558 C/G cg17385448 chr1:15911702 AGMAT 0.37 6.06 0.31 3.7e-9 Systolic blood pressure; LUSC cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 6.61 0.34 1.54e-10 Rheumatoid arthritis; LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg04944784 chr2:26401820 FAM59B -0.74 -10.91 -0.51 6.48e-24 Gut microbiome composition (summer); LUSC cis rs4363385 0.818 rs1334848 chr1:153004721 A/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.42e-12 Inflammatory skin disease; LUSC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.82 -0.39 6.91e-14 Personality dimensions; LUSC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.83 -0.3 1.31e-8 Reticulocyte fraction of red cells; LUSC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.09 14.43 0.62 5.1e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg22535103 chr8:58192502 C8orf71 0.66 7.28 0.37 2.48e-12 Developmental language disorder (linguistic errors); LUSC cis rs35150201 0.517 rs10260691 chr7:135328110 C/T cg23117316 chr7:135346802 PL-5283 0.34 6.94 0.35 2.05e-11 Plateletcrit;Mean corpuscular hemoglobin;Mean platelet volume; LUSC cis rs782590 0.869 rs782599 chr2:55847423 C/T cg03859395 chr2:55845619 SMEK2 0.81 14.82 0.63 1.47e-38 Metabolic syndrome; LUSC cis rs870825 0.860 rs55974219 chr4:185600733 G/A cg04058563 chr4:185651563 MLF1IP 0.83 11.65 0.54 1.45e-26 Blood protein levels; LUSC cis rs6693567 0.565 rs497128 chr1:150269952 A/G cg15654264 chr1:150340011 RPRD2 -0.45 -7.4 -0.38 1.09e-12 Migraine; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg08472276 chr7:1133186 C7orf50;GPER -0.4 -6.48 -0.33 3.31e-10 Longevity;Endometriosis; LUSC trans rs35110281 0.666 rs2838348 chr21:45107285 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.61 -10.38 -0.49 4.44e-22 Mean corpuscular volume; LUSC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.61 -8.44 -0.42 1.01e-15 Mean platelet volume; LUSC cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9300255 0.739 rs1969354 chr12:123741776 T/C cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.36 -0.33 6.57e-10 Neutrophil percentage of white cells; LUSC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg11764359 chr7:65958608 NA 0.51 6.6 0.34 1.58e-10 Aortic root size; LUSC cis rs9463078 0.625 rs679713 chr6:44899632 T/C cg25276700 chr6:44698697 NA -0.27 -5.71 -0.3 2.52e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg13047869 chr3:10149882 C3orf24 0.65 9.51 0.46 3.98e-19 Alzheimer's disease; LUSC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.12 0.36 6.71e-12 Blood metabolite levels; LUSC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg19748678 chr4:122722346 EXOSC9 0.74 10.58 0.5 9.68e-23 Type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06943149 chr12:77157476 ZDHHC17 0.45 6.75 0.35 6.65e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs981844 0.890 rs55917677 chr4:154701051 C/T cg14289246 chr4:154710475 SFRP2 0.53 6.67 0.34 1.06e-10 Response to statins (LDL cholesterol change); LUSC cis rs2652834 0.808 rs966331 chr15:63411927 T/C cg05507819 chr15:63340323 TPM1 0.44 5.69 0.3 2.79e-8 HDL cholesterol; LUSC trans rs10802346 0.545 rs1770003 chr1:246408356 A/G cg13514129 chr1:39547527 MACF1 0.71 11.58 0.54 2.64e-26 Fractional exhaled nitric oxide (childhood); LUSC cis rs9790314 1.000 rs9846756 chr3:160983809 A/C cg04691961 chr3:161091175 C3orf57 -0.34 -5.8 -0.3 1.5e-8 Morning vs. evening chronotype; LUSC cis rs9837602 1.000 rs6799379 chr3:99762840 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.13 -0.32 2.52e-9 Breast cancer; LUSC cis rs12291225 0.679 rs11369 chr11:14288096 A/G cg05501817 chr11:14380813 RRAS2 -0.57 -9.06 -0.44 1.08e-17 Sense of smell; LUSC cis rs244731 0.959 rs6872021 chr5:176610012 G/A cg16006841 chr5:176797999 RGS14 -0.66 -9.56 -0.46 2.58e-19 Urate levels in lean individuals; LUSC cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.92 13.52 0.59 1.54e-33 Chronic sinus infection; LUSC cis rs11098499 0.779 rs72918579 chr4:120333222 G/C cg09307838 chr4:120376055 NA 0.78 11.23 0.52 4.93e-25 Corneal astigmatism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00722097 chr6:111195976 AMD1 -0.57 -7.01 -0.36 1.35e-11 Bipolar disorder and schizophrenia; LUSC cis rs9807989 0.507 rs1420094 chr2:103015687 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.19e-12 Asthma; LUSC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg05585544 chr11:47624801 NA -0.42 -7.25 -0.37 3.01e-12 Subjective well-being; LUSC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg12463550 chr7:65579703 CRCP 0.52 7.54 0.38 4.45e-13 Aortic root size; LUSC cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg04518342 chr5:131593106 PDLIM4 -0.36 -5.97 -0.31 6.14e-9 Blood metabolite levels; LUSC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg18827107 chr12:86230957 RASSF9 0.45 6.86 0.35 3.4e-11 Major depressive disorder; LUSC cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg09626299 chr10:82213104 TSPAN14 -0.21 -6.01 -0.31 4.85e-9 Post bronchodilator FEV1; LUSC cis rs9311676 0.656 rs55692656 chr3:58383174 A/T cg13750441 chr3:58318267 PXK 0.34 6.63 0.34 1.37e-10 Systemic lupus erythematosus; LUSC trans rs11098499 0.566 rs17051356 chr4:120585308 C/T cg25214090 chr10:38739885 LOC399744 0.5 7.07 0.36 9.33e-12 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11047049 chr3:195163937 ACAP2 -0.45 -6.77 -0.35 5.63e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10782582 0.593 rs115291524 chr1:76141811 A/G cg03433033 chr1:76189801 ACADM -0.43 -6.4 -0.33 5.14e-10 Daytime sleep phenotypes; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 3.1e-34 Prudent dietary pattern; LUSC cis rs9815354 0.812 rs116393551 chr3:41865476 G/A cg03022575 chr3:42003672 ULK4 0.85 8.9 0.44 3.75e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs8017423 1.000 rs10129210 chr14:90668379 G/T cg14092571 chr14:90743983 NA -0.36 -5.85 -0.31 1.14e-8 Mortality in heart failure; LUSC cis rs11098499 0.913 rs13126596 chr4:120140729 A/G cg09307838 chr4:120376055 NA 0.68 9.75 0.47 6.31e-20 Corneal astigmatism; LUSC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg26818010 chr10:134567672 INPP5A -0.85 -10.78 -0.51 1.87e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2295359 0.892 rs10789224 chr1:67605134 C/T cg12940439 chr1:67600707 NA -0.39 -6.49 -0.33 3.02e-10 Psoriasis; LUSC cis rs1572072 0.545 rs1572069 chr13:24124492 A/C cg24350296 chr13:24144486 TNFRSF19 -0.31 -5.68 -0.3 2.93e-8 Nasopharyngeal carcinoma; LUSC cis rs1348850 0.831 rs1345139 chr2:178449791 G/T cg22681709 chr2:178499509 PDE11A -0.47 -8.55 -0.42 4.45e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs8072100 0.905 rs9901869 chr17:45575206 G/A cg08085267 chr17:45401833 C17orf57 -0.54 -8.6 -0.43 3.07e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg00339695 chr16:24857497 SLC5A11 0.59 8.98 0.44 2.04e-17 Intelligence (multi-trait analysis); LUSC cis rs2425143 0.730 rs6060624 chr20:34413663 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -5.84 -0.3 1.27e-8 Blood protein levels; LUSC trans rs208520 0.690 rs4386800 chr6:66755242 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.86 0.68 1.45e-46 Exhaled nitric oxide output; LUSC cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg22117172 chr7:91764530 CYP51A1 0.32 5.71 0.3 2.49e-8 Breast cancer; LUSC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg19717773 chr7:2847554 GNA12 -0.41 -6.45 -0.33 3.94e-10 Height; LUSC cis rs1577917 0.959 rs16876540 chr6:86612519 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.73 -0.35 7.42e-11 Response to antipsychotic treatment; LUSC cis rs752010 0.746 rs10749837 chr1:42089471 T/C cg06885757 chr1:42089581 HIVEP3 0.52 11.17 0.52 8.18e-25 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7572644 0.640 rs4665392 chr2:28029649 A/G cg27432699 chr2:27873401 GPN1 0.55 7.3 0.37 2.19e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs12824058 0.737 rs2398508 chr12:130816460 G/A cg26677194 chr12:130822605 PIWIL1 0.59 8.31 0.41 2.52e-15 Menopause (age at onset); LUSC cis rs9300255 0.544 rs1716175 chr12:123658388 A/T cg00376283 chr12:123451042 ABCB9 0.67 8.45 0.42 9.23e-16 Neutrophil percentage of white cells; LUSC cis rs7605827 0.823 rs6431692 chr2:15478364 A/G cg19274914 chr2:15703543 NA 0.42 8.11 0.41 9.59e-15 Educational attainment (years of education); LUSC cis rs12220238 0.908 rs11000893 chr10:75905996 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.94 0.36 2.02e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs56161922 0.915 rs12563415 chr1:207856666 G/T cg11752769 chr1:207818423 CR1L -0.71 -6.0 -0.31 5.07e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs9814567 0.929 rs2241556 chr3:134183312 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.77 11.85 0.54 2.69e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs6696846 0.765 rs11576867 chr1:205064676 C/T cg00857998 chr1:205179979 DSTYK 0.62 9.8 0.47 4.27e-20 Red blood cell count; LUSC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 1.000 rs6037099 chr20:25356876 T/G cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg14584255 chr6:163149320 PACRG;PARK2 -0.39 -7.53 -0.38 4.66e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs35860234 0.806 rs6561054 chr13:43059882 C/T cg17512187 chr2:85082845 C2orf89 -0.26 -6.1 -0.32 2.89e-9 Vitiligo; LUSC cis rs12541635 0.934 rs1353450 chr8:107035120 A/G cg10147462 chr8:107024639 NA -0.54 -9.93 -0.48 1.53e-20 Age of smoking initiation; LUSC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg11764359 chr7:65958608 NA 0.52 6.71 0.34 8.57e-11 Aortic root size; LUSC cis rs6598955 0.671 rs7550997 chr1:26596080 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.71 -0.3 2.47e-8 Obesity-related traits; LUSC cis rs2625529 0.824 rs12899485 chr15:72143215 A/G cg16672083 chr15:72433130 SENP8 0.48 7.17 0.37 4.95e-12 Red blood cell count; LUSC cis rs8060686 0.545 rs75229939 chr16:68164949 G/A cg05110241 chr16:68378359 PRMT7 -0.64 -6.74 -0.35 6.99e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.08 0.36 8.38e-12 Platelet count; LUSC cis rs427394 0.743 rs274716 chr5:6722289 T/C cg10857441 chr5:6722123 POLS -0.48 -8.99 -0.44 1.85e-17 Menopause (age at onset); LUSC trans rs75804782 0.641 rs11904390 chr2:239344663 T/A cg01134436 chr17:81009848 B3GNTL1 0.63 6.13 0.32 2.54e-9 Morning vs. evening chronotype;Chronotype; LUSC trans rs9886428 1.000 rs7839860 chr8:14113760 C/T cg11959399 chr20:741723 C20orf54 0.39 6.35 0.33 7.19e-10 IgG glycosylation; LUSC cis rs11098499 0.866 rs11098506 chr4:120284971 A/G cg09307838 chr4:120376055 NA 0.68 10.0 0.48 8.88e-21 Corneal astigmatism; LUSC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg00343986 chr7:65444356 GUSB 0.43 6.55 0.34 2.22e-10 Aortic root size; LUSC cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg08798685 chr6:27730294 NA -0.64 -6.01 -0.31 4.93e-9 Breast cancer; LUSC cis rs6693567 0.565 rs1776273 chr1:150270209 C/T cg15654264 chr1:150340011 RPRD2 0.41 6.7 0.34 8.85e-11 Migraine; LUSC cis rs10464366 0.746 rs4723821 chr7:39141532 A/G cg18850127 chr7:39170497 POU6F2 0.62 9.32 0.45 1.58e-18 IgG glycosylation; LUSC cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.27 0.49 1.1e-21 Bladder cancer; LUSC cis rs7712401 0.601 rs246269 chr5:122256741 T/C cg19077854 chr5:122220652 SNX24 0.42 9.55 0.46 2.79e-19 Mean platelet volume; LUSC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg12257692 chr3:49977190 RBM6 0.24 6.8 0.35 4.88e-11 Body mass index; LUSC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg00810483 chr4:3375144 RGS12 0.3 5.73 0.3 2.22e-8 Serum sulfate level; LUSC cis rs354225 0.544 rs3287 chr2:54807657 T/C cg01766943 chr2:54829624 SPTBN1 0.48 7.76 0.39 1.05e-13 Schizophrenia; LUSC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg04944784 chr2:26401820 FAM59B -0.71 -10.06 -0.48 5.61e-21 Gut microbiome composition (summer); LUSC cis rs8141529 0.588 rs10222249 chr22:29257147 A/G cg02153584 chr22:29168773 CCDC117 0.54 7.24 0.37 3.02e-12 Lymphocyte counts; LUSC cis rs10979 1.000 rs9403504 chr6:143885430 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.02 -0.55 6.53e-28 Hypospadias; LUSC cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.6 -0.57 4.58e-30 Chronic sinus infection; LUSC cis rs2637266 0.967 rs12246430 chr10:78352879 C/T cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.53e-12 Pulmonary function; LUSC cis rs941408 0.515 rs4624312 chr19:2774460 T/C cg17333051 chr19:2783644 SGTA 0.49 7.42 0.38 9.84e-13 Total cholesterol levels; LUSC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg09034736 chr1:150693464 HORMAD1 -0.46 -6.58 -0.34 1.86e-10 Melanoma; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg03379200 chr15:91537914 PRC1 0.44 6.18 0.32 1.92e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs8017423 0.967 rs2277514 chr14:90723059 T/C cg14092571 chr14:90743983 NA -0.36 -5.86 -0.31 1.11e-8 Mortality in heart failure; LUSC cis rs7103648 0.712 rs10838703 chr11:47422861 C/G cg20307385 chr11:47447363 PSMC3 0.86 13.09 0.58 6.74e-32 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg06363034 chr20:62225388 GMEB2 -0.46 -7.68 -0.39 1.79e-13 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs6539267 0.741 rs35816179 chr12:106693710 T/C cg02476566 chr12:106696527 TCP11L2 0.53 6.63 0.34 1.38e-10 Tourette syndrome; LUSC trans rs66573146 1.000 rs6838250 chr4:6973184 C/G cg07817883 chr1:32538562 TMEM39B 1.47 12.2 0.56 1.43e-28 Granulocyte percentage of myeloid white cells; LUSC cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg08999081 chr20:33150536 PIGU 0.52 10.36 0.49 5.48e-22 Glomerular filtration rate (creatinine); LUSC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg21138405 chr5:131827807 IRF1 0.56 10.98 0.52 3.71e-24 Asthma (sex interaction); LUSC cis rs75804782 0.521 rs60779166 chr2:239433943 G/A cg18131467 chr2:239335373 ASB1 -0.7 -6.01 -0.31 4.98e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg11247378 chr22:39784982 NA -0.64 -11.42 -0.53 1.03e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs966423 0.527 rs6723847 chr2:218256489 C/T cg15335768 chr2:218268053 DIRC3 -0.3 -6.26 -0.32 1.16e-9 Thyroid cancer; LUSC cis rs11250464 1.000 rs11250464 chr10:1406364 A/G cg26394196 chr10:1453818 ADARB2 -0.38 -6.52 -0.34 2.67e-10 Radiation response; LUSC cis rs7927592 0.956 rs7102273 chr11:68385579 T/C cg20283391 chr11:68216788 NA -0.57 -8.11 -0.41 9.78e-15 Total body bone mineral density; LUSC cis rs9361491 0.508 rs9359338 chr6:79396751 T/C cg05283184 chr6:79620031 NA -0.4 -7.05 -0.36 1.05e-11 Intelligence (multi-trait analysis); LUSC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC trans rs877282 0.891 rs11253355 chr10:768367 C/G cg22713356 chr15:30763199 NA 1.09 15.45 0.65 5.42e-41 Uric acid levels; LUSC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.7 0.34 9.07e-11 Intelligence (multi-trait analysis); LUSC cis rs929843 1 rs929843 chr16:70045748 A/C cg09409435 chr16:70099608 PDXDC2 0.84 11.75 0.54 6.22e-27 Menarche (age at onset); LUSC cis rs9303401 0.659 rs17822735 chr17:56620167 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.34 0.59 8.12e-33 Cognitive test performance; LUSC cis rs478304 0.654 rs12289836 chr11:65436888 C/T cg10518572 chr11:65560635 OVOL1 0.26 5.83 0.3 1.28e-8 Acne (severe); LUSC cis rs9549367 0.773 rs9549717 chr13:113908826 A/G cg18105134 chr13:113819100 PROZ -0.65 -9.59 -0.46 2.1e-19 Platelet distribution width; LUSC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg06634786 chr22:41940651 POLR3H 0.5 6.01 0.31 4.81e-9 Vitiligo; LUSC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.46 -8.44 -0.42 9.51e-16 Total body bone mineral density; LUSC cis rs4356932 1.000 rs6852075 chr4:76952280 T/G cg00809888 chr4:76862425 NAAA 0.35 5.77 0.3 1.78e-8 Blood protein levels; LUSC cis rs7677751 0.806 rs1800812 chr4:55094629 G/T cg17187183 chr4:55093834 PDGFRA 0.39 5.89 0.31 9.61e-9 Corneal astigmatism; LUSC cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC trans rs11039798 1.000 rs10769370 chr11:48515430 A/G cg03929089 chr4:120376271 NA 0.67 6.32 0.33 8.22e-10 Axial length; LUSC cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.45 0.33 3.85e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg23933602 chr10:16859644 RSU1 0.62 7.71 0.39 1.45e-13 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs9902453 0.899 rs1979572 chr17:28511978 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 8.21 0.41 4.76e-15 Coffee consumption (cups per day); LUSC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.32 6.36 0.33 6.54e-10 Schizophrenia; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18758796 chr5:131593413 PDLIM4 -0.49 -7.89 -0.4 4.44e-14 Acylcarnitine levels; LUSC cis rs79149102 0.737 rs74450883 chr15:75193432 A/G cg09165964 chr15:75287851 SCAMP5 -0.91 -6.84 -0.35 3.82e-11 Lung cancer; LUSC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.1 0.41 1.01e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs6430585 0.528 rs309122 chr2:136761853 A/G cg07169764 chr2:136633963 MCM6 1.05 16.81 0.68 2.14e-46 Corneal structure; LUSC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg03684893 chr10:554711 DIP2C -0.37 -6.68 -0.34 9.82e-11 Psychosis in Alzheimer's disease; LUSC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg09365446 chr1:150670422 GOLPH3L 0.53 8.09 0.4 1.15e-14 Tonsillectomy; LUSC trans rs9393777 0.920 rs72839445 chr6:27249686 G/A cg01620082 chr3:125678407 NA -0.76 -6.88 -0.35 3.05e-11 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.16 0.55 2.03e-28 Motion sickness; LUSC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.42 0.33 4.71e-10 Menopause (age at onset); LUSC cis rs1443512 0.773 rs2366146 chr12:54331002 G/A cg25024717 chr12:54324583 NA -0.39 -6.81 -0.35 4.42e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg26597838 chr10:835615 NA 1.24 16.83 0.68 1.79e-46 Eosinophil percentage of granulocytes; LUSC cis rs981844 0.712 rs2405208 chr4:154755774 T/C cg14289246 chr4:154710475 SFRP2 -0.46 -6.41 -0.33 4.85e-10 Response to statins (LDL cholesterol change); LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg05368731 chr17:41323189 NBR1 0.93 16.05 0.66 2.27e-43 Menopause (age at onset); LUSC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.38 0.33 5.94e-10 Personality dimensions; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg01802117 chr1:53393560 SCP2 -0.37 -6.17 -0.32 1.97e-9 Monocyte count; LUSC cis rs11051970 0.918 rs12229856 chr12:32531220 C/T cg02745156 chr12:32552066 NA 0.43 6.99 0.36 1.46e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12980942 0.591 rs2304231 chr19:41762670 T/C cg25627403 chr19:41769009 HNRNPUL1 0.69 7.28 0.37 2.47e-12 Coronary artery disease; LUSC cis rs7131987 0.903 rs67517901 chr12:29421346 A/G cg09582351 chr12:29534625 ERGIC2 -0.33 -6.71 -0.34 8.15e-11 QT interval; LUSC cis rs4494114 0.967 rs1925677 chr1:39346905 T/G cg25970120 chr1:39325951 RRAGC -0.39 -6.08 -0.32 3.27e-9 Blood protein levels; LUSC cis rs7828089 0.934 rs12544427 chr8:22263115 C/T cg12081754 chr8:22256438 SLC39A14 -0.54 -8.54 -0.42 4.75e-16 Verbal declarative memory; LUSC cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.08 0.52 1.59e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12891047 1.000 rs11158693 chr14:68241261 A/G cg20999565 chr14:68265668 ZFYVE26 0.38 5.82 0.3 1.38e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg00376283 chr12:123451042 ABCB9 -0.65 -9.5 -0.46 4.28e-19 Height;Educational attainment;Head circumference (infant); LUSC cis rs7527798 0.592 rs2025372 chr1:207829653 T/G cg09232269 chr1:207846808 CR1L -0.3 -6.4 -0.33 5.18e-10 Erythrocyte sedimentation rate; LUSC cis rs71335811 1 rs71335811 chr19:49130070 TC/T cg06677660 chr19:49140777 SEC1;DBP -0.44 -5.66 -0.3 3.31e-8 Myeloid white cell count; LUSC cis rs10484885 0.757 rs12201016 chr6:90149275 C/T cg13799429 chr6:90582589 CASP8AP2 0.6 5.87 0.31 1.03e-8 QRS interval (sulfonylurea treatment interaction); LUSC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg01125463 chr6:42946178 PEX6 -0.36 -5.97 -0.31 6.19e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7824557 0.564 rs7834572 chr8:11236685 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.79 -0.3 1.63e-8 Retinal vascular caliber; LUSC cis rs11711311 0.955 rs12630833 chr3:113390883 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.32 0.33 8.24e-10 IgG glycosylation; LUSC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs7568458 0.709 rs762684 chr2:85782023 G/A cg02493740 chr2:85810744 VAMP5 -0.54 -9.48 -0.46 4.82e-19 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.38 6.61 0.34 1.54e-10 Total body bone mineral density; LUSC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg27121462 chr16:89883253 FANCA 0.42 6.45 0.33 3.83e-10 Vitiligo; LUSC cis rs4478858 0.775 rs6701861 chr1:31708125 A/C cg00250761 chr1:31883323 NA -0.36 -9.53 -0.46 3.29e-19 Alcohol dependence; LUSC cis rs1003719 0.680 rs2835629 chr21:38521660 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.54 -0.5 1.26e-22 Eye color traits; LUSC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg00990874 chr7:1149470 C7orf50 -0.6 -7.8 -0.39 8.03e-14 Bronchopulmonary dysplasia; LUSC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg07936489 chr17:37558343 FBXL20 0.71 9.91 0.48 1.88e-20 Glomerular filtration rate (creatinine); LUSC cis rs9467773 1.000 rs1884946 chr6:26545308 C/G cg05738196 chr6:26577821 NA 0.81 15.74 0.65 3.89e-42 Intelligence (multi-trait analysis); LUSC cis rs2479724 0.868 rs2249703 chr6:41814760 A/G cg17623882 chr6:41773611 USP49 -0.63 -10.69 -0.5 3.9e-23 Menarche (age at onset); LUSC trans rs7726839 0.574 rs72705014 chr5:619815 C/G cg25482853 chr8:67687455 SGK3 1.11 15.36 0.64 1.21e-40 Obesity-related traits; LUSC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg05890377 chr2:74357713 NA 0.72 13.81 0.6 1.25e-34 Gestational age at birth (maternal effect); LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg01879757 chr17:41196368 BRCA1 -0.45 -6.9 -0.35 2.62e-11 Menopause (age at onset); LUSC cis rs4919694 0.901 rs10509763 chr10:104776391 G/A cg04362960 chr10:104952993 NT5C2 1.17 13.65 0.6 5.27e-34 Arsenic metabolism; LUSC cis rs56104184 0.830 rs17206679 chr19:49342237 C/G cg15549821 chr19:49342101 PLEKHA4 -0.88 -11.25 -0.52 4.06e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs11583043 1.000 rs6675353 chr1:101459625 A/T cg11406453 chr1:101602562 NA -0.32 -5.66 -0.3 3.3e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg14092988 chr3:52407081 DNAH1 0.31 6.05 0.31 3.96e-9 Bipolar disorder; LUSC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg05855489 chr10:104503620 C10orf26 0.57 9.18 0.45 4.51e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12519773 0.517 rs17360811 chr5:92492349 G/A cg18783429 chr5:92414398 NA 0.32 6.76 0.35 6.04e-11 Migraine; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16204370 chr22:41682343 RANGAP1 0.53 7.41 0.38 1.01e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8014204 0.901 rs2080087 chr14:75365062 C/T cg08847533 chr14:75593920 NEK9 0.4 5.75 0.3 2.04e-8 Caffeine consumption; LUSC cis rs116988415 0.584 rs77490765 chr14:65278537 T/G cg25083366 chr14:65239357 SPTB 0.68 6.82 0.35 4.31e-11 Daytime sleep phenotypes; LUSC trans rs6601327 0.606 rs13268319 chr8:9579249 C/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.57 -0.34 1.97e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg12257692 chr3:49977190 RBM6 0.25 7.03 0.36 1.2e-11 Intelligence (multi-trait analysis); LUSC cis rs9902453 0.740 rs2254414 chr17:28061130 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.16 -0.52 8.95e-25 Coffee consumption (cups per day); LUSC cis rs7177699 0.557 rs34372090 chr15:79110735 C/T cg15571903 chr15:79123663 NA -0.33 -5.99 -0.31 5.49e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg08975724 chr8:8085496 FLJ10661 0.46 6.71 0.34 8.55e-11 Retinal vascular caliber; LUSC trans rs7615952 0.599 rs60847438 chr3:125746005 T/C cg07211511 chr3:129823064 LOC729375 -0.77 -9.74 -0.47 6.53e-20 Blood pressure (smoking interaction); LUSC cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg26384229 chr12:38710491 ALG10B 0.88 14.69 0.63 5.1e-38 Bladder cancer; LUSC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg26597838 chr10:835615 NA 0.79 9.73 0.47 7.58e-20 Eosinophil percentage of granulocytes; LUSC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.58 8.48 0.42 7.28e-16 Total body bone mineral density; LUSC cis rs1775715 0.675 rs2808085 chr10:32148599 C/T cg26784012 chr10:32216390 ARHGAP12 0.45 7.7 0.39 1.54e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs698833 0.506 rs4952705 chr2:44499867 T/C cg00619915 chr2:44497795 NA -0.53 -7.2 -0.37 4.13e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs11155671 0.530 rs7774787 chr6:150209432 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.69 -0.3 2.72e-8 Testicular germ cell tumor; LUSC cis rs4499344 0.577 rs259289 chr19:33164927 G/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.73 0.54 7.5e-27 Mean platelet volume; LUSC cis rs2204008 0.714 rs11520135 chr12:38114863 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.8 0.51 1.57e-23 Bladder cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27297724 chr4:48781911 FRYL 0.49 6.78 0.35 5.56e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg13170934 chr1:156722147 HDGF 0.49 6.05 0.31 3.82e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9914988 0.943 rs67327562 chr17:27108828 G/A cg09479241 chr17:27052676 TLCD1 0.44 5.94 0.31 7.01e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs59104589 0.550 rs73002181 chr2:242342379 C/G cg14842376 chr2:242211374 HDLBP 0.6 6.28 0.33 1.04e-9 Fibrinogen levels; LUSC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg02782426 chr3:40428986 ENTPD3 0.39 7.46 0.38 7.6e-13 Renal cell carcinoma; LUSC trans rs2243480 1.000 rs59794892 chr7:65415873 G/A cg10756647 chr7:56101905 PSPH 0.87 8.46 0.42 8.32e-16 Diabetic kidney disease; LUSC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg15448220 chr1:150897856 SETDB1 0.41 6.06 0.31 3.69e-9 Melanoma; LUSC cis rs1008375 0.618 rs13129002 chr4:17567513 A/G cg16339924 chr4:17578868 LAP3 0.57 7.73 0.39 1.28e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg07606381 chr6:8435919 SLC35B3 0.71 12.29 0.56 6.91e-29 Motion sickness; LUSC cis rs7100689 0.646 rs1340374 chr10:82129114 C/T cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.62 -9.4 -0.46 8.77e-19 Personality dimensions; LUSC cis rs9388451 0.839 rs3799711 chr6:126075313 C/T cg10911889 chr6:126070802 HEY2 -0.42 -6.47 -0.33 3.45e-10 Brugada syndrome; LUSC cis rs9323205 1.000 rs12589519 chr14:51596684 C/G cg23942311 chr14:51606299 NA -0.48 -9.67 -0.47 1.16e-19 Cancer; LUSC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg22437258 chr11:111473054 SIK2 0.53 7.45 0.38 7.84e-13 Primary sclerosing cholangitis; LUSC cis rs10484885 0.878 rs55750696 chr6:90552336 G/A cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.04 -0.4 1.6e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg02788857 chr8:22132959 PIWIL2 0.39 7.65 0.39 2.11e-13 Hypertriglyceridemia; LUSC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg22535103 chr8:58192502 C8orf71 -0.58 -6.86 -0.35 3.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg04450456 chr4:17643702 FAM184B 0.43 7.21 0.37 3.8e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9650315 0.866 rs13281759 chr8:57193582 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.12 0.36 6.75e-12 Height; LUSC cis rs7000551 0.715 rs7828610 chr8:22307326 C/T cg12081754 chr8:22256438 SLC39A14 0.48 7.58 0.38 3.44e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.57 -7.01 -0.36 1.33e-11 Lung function (FEV1/FVC); LUSC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.96 16.98 0.68 4.78e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg23985595 chr17:80112537 CCDC57 0.31 5.84 0.3 1.23e-8 Life satisfaction; LUSC cis rs6977660 0.714 rs10231980 chr7:19789383 C/G cg05791153 chr7:19748676 TWISTNB 0.76 8.48 0.42 7.52e-16 Thyroid stimulating hormone; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04654365 chr17:19281636 MAPK7 0.75 6.42 0.33 4.62e-10 Cognitive performance; LUSC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg20503657 chr10:835505 NA 1.22 16.34 0.67 1.68e-44 Eosinophil percentage of granulocytes; LUSC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg25809561 chr17:30822961 MYO1D 0.53 8.88 0.44 4.14e-17 Schizophrenia; LUSC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg17143192 chr8:8559678 CLDN23 0.66 9.61 0.47 1.84e-19 Obesity-related traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03603505 chr12:122839920 CLIP1 0.52 6.92 0.35 2.26e-11 Bipolar disorder and schizophrenia; LUSC cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -8.49 -0.42 6.65e-16 Bone mineral density; LUSC cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg26384229 chr12:38710491 ALG10B 0.94 17.87 0.7 1.34e-50 Heart rate; LUSC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg16989086 chr20:62203971 PRIC285 0.46 6.47 0.33 3.56e-10 Glioblastoma; LUSC cis rs5009270 0.553 rs62476688 chr7:112232716 C/T cg23628563 chr7:112262597 NA 0.43 5.92 0.31 8.16e-9 Osteoarthritis (hip); LUSC trans rs9784649 1.000 rs55924805 chr5:24999756 C/T cg08600765 chr20:34638493 LOC647979 -0.54 -6.42 -0.33 4.74e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2439831 0.850 rs28858500 chr15:44156942 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.84 0.35 3.78e-11 Lung cancer in ever smokers; LUSC trans rs11098499 0.955 rs56386062 chr4:120155135 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg11366901 chr6:160182831 ACAT2 0.89 11.5 0.53 5.3e-26 Age-related macular degeneration (geographic atrophy); LUSC cis rs870825 0.616 rs6844146 chr4:185636396 G/A cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC trans rs10028773 0.700 rs7671797 chr4:120248157 A/G cg25214090 chr10:38739885 LOC399744 0.43 6.49 0.33 3.12e-10 Educational attainment; LUSC cis rs9905704 0.918 rs12947196 chr17:56902444 G/A cg12560992 chr17:57184187 TRIM37 0.57 8.05 0.4 1.47e-14 Testicular germ cell tumor; LUSC cis rs8017423 0.935 rs11624246 chr14:90734826 A/G cg14092571 chr14:90743983 NA 0.36 5.78 0.3 1.69e-8 Mortality in heart failure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24806732 chr17:7608859 EFNB3 0.4 6.05 0.31 3.83e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.76 -0.3 1.92e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2236918 0.710 rs1626057 chr1:242038136 G/C cg17736920 chr1:242011382 EXO1 0.41 6.34 0.33 7.52e-10 Menopause (age at onset); LUSC cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg04756594 chr16:24857601 SLC5A11 0.35 5.83 0.3 1.31e-8 Intelligence (multi-trait analysis); LUSC cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg26384229 chr12:38710491 ALG10B 0.93 17.21 0.69 5.86e-48 Heart rate; LUSC cis rs3126085 0.935 rs1466757 chr1:152212469 G/A cg03465714 chr1:152285911 FLG -0.4 -5.67 -0.3 3.07e-8 Atopic dermatitis; LUSC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6722750 1.000 rs4671552 chr2:64393955 A/G cg22352474 chr2:64371530 PELI1 0.57 8.63 0.43 2.62e-16 Neuroticism; LUSC cis rs4242434 0.889 rs4592028 chr8:22449484 T/C cg03733263 chr8:22462867 KIAA1967 1.0 17.88 0.7 1.2e-50 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg22676075 chr6:135203613 NA 0.55 8.72 0.43 1.37e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs11039798 0.588 rs10838979 chr11:48626810 T/G cg15704280 chr7:45808275 SEPT13 0.65 7.19 0.37 4.24e-12 Axial length; LUSC trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs13064411 0.660 rs3829889 chr3:113015464 G/A cg18753928 chr3:113234510 CCDC52 -0.43 -6.24 -0.32 1.36e-9 Response to simvastatin treatment (PCSK9 protein level change); LUSC trans rs6600671 1.000 rs11249351 chr1:121171942 G/A cg08727972 chr1:148025634 NBPF14 0.45 6.25 0.32 1.24e-9 Hip geometry; LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg25036284 chr2:26402008 FAM59B 0.68 9.15 0.45 5.62e-18 Gut microbiome composition (summer); LUSC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg23711669 chr6:146136114 FBXO30 -0.78 -12.9 -0.58 3.58e-31 Lobe attachment (rater-scored or self-reported); LUSC trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg27661571 chr11:113659931 NA -0.64 -6.68 -0.34 9.75e-11 Hip circumference adjusted for BMI; LUSC cis rs8078723 0.546 rs8067817 chr17:38163936 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.59 -10.47 -0.5 2.34e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2979489 0.891 rs2915591 chr8:30395948 C/G cg26383811 chr8:30366931 RBPMS -0.52 -8.16 -0.41 6.8e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs1577917 0.839 rs6454492 chr6:86483214 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -6.47 -0.33 3.53e-10 Response to antipsychotic treatment; LUSC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs611744 0.647 rs676654 chr8:109242303 A/G cg21045802 chr8:109455806 TTC35 0.43 6.37 0.33 6.29e-10 Dupuytren's disease; LUSC cis rs1832871 0.711 rs6920506 chr6:158695017 T/A cg07165851 chr6:158734300 TULP4 0.5 7.8 0.39 7.87e-14 Height; LUSC cis rs2282802 0.677 rs9686454 chr5:139627813 T/C cg26211634 chr5:139558579 C5orf32 0.43 8.11 0.41 9.51e-15 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.44 6.62 0.34 1.45e-10 Menarche (age at onset); LUSC cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg01579765 chr21:45077557 HSF2BP -0.47 -9.64 -0.47 1.5e-19 Mean corpuscular volume; LUSC trans rs9951602 0.512 rs12458828 chr18:76648522 C/T cg02800362 chr5:177631904 HNRNPAB -0.89 -13.16 -0.58 3.82e-32 Obesity-related traits; LUSC cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg05283184 chr6:79620031 NA -0.57 -11.83 -0.54 3.38e-27 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20972416 chr2:220025218 NHEJ1 0.48 6.65 0.34 1.2e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18861140 chr18:3449789 TGIF1 -0.49 -6.52 -0.34 2.6e-10 Bipolar disorder and schizophrenia; LUSC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg18512352 chr11:47633146 NA -0.48 -9.6 -0.47 1.94e-19 Subjective well-being; LUSC cis rs2273669 0.667 rs2145765 chr6:109296362 C/G cg05315195 chr6:109294784 ARMC2 -0.58 -6.45 -0.33 4.03e-10 Prostate cancer; LUSC cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg08213375 chr14:104286397 PPP1R13B 0.53 10.51 0.5 1.69e-22 Schizophrenia; LUSC cis rs10208940 0.920 rs7571506 chr2:68836317 C/A cg12452813 chr2:68675892 NA 0.55 5.67 0.3 3.06e-8 Urate levels in lean individuals; LUSC cis rs7246657 0.943 rs28373708 chr19:37976659 C/T cg23950597 chr19:37808831 NA -0.65 -7.67 -0.39 1.89e-13 Coronary artery calcification; LUSC cis rs4654899 0.758 rs12137408 chr1:21282945 A/G cg01072550 chr1:21505969 NA -0.53 -8.03 -0.4 1.67e-14 Superior frontal gyrus grey matter volume; LUSC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg24675658 chr1:53192096 ZYG11B -0.56 -8.81 -0.43 6.7e-17 Monocyte count; LUSC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg20607798 chr8:58055168 NA 0.6 8.05 0.4 1.45e-14 Developmental language disorder (linguistic errors); LUSC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg11752832 chr7:134001865 SLC35B4 0.6 9.54 0.46 3.17e-19 Mean platelet volume; LUSC cis rs7124681 0.584 rs12226590 chr11:47571808 T/C cg20307385 chr11:47447363 PSMC3 0.42 5.98 0.31 5.88e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs11971779 0.680 rs10229249 chr7:139052510 A/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg04013166 chr16:89971882 TCF25 0.54 5.92 0.31 7.93e-9 Skin colour saturation; LUSC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg08499158 chr17:42289980 UBTF 0.4 6.12 0.32 2.6e-9 Total body bone mineral density; LUSC cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.03 0.48 7.45e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs12940923 0.935 rs11079342 chr17:56367633 G/C cg19466818 chr17:56409534 MIR142 -0.39 -6.87 -0.35 3.19e-11 Circulating myeloperoxidase levels (plasma); LUSC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC trans rs1864729 1.000 rs2567773 chr8:98279182 G/A cg08679828 chr8:102218111 ZNF706 -0.81 -7.38 -0.37 1.28e-12 Estradiol plasma levels (breast cancer); LUSC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg00745463 chr17:30367425 LRRC37B 0.78 8.66 0.43 2.06e-16 Hip circumference adjusted for BMI; LUSC cis rs4566357 1.000 rs6705989 chr2:227923320 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.17 0.37 4.94e-12 Cognitive ability; LUSC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg06792262 chr3:44622596 ZNF167 0.35 5.96 0.31 6.42e-9 Depressive symptoms; LUSC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg02376097 chr19:46275166 DMPK 0.39 6.94 0.35 2.06e-11 Coronary artery disease; LUSC cis rs8078723 1.000 rs709592 chr17:38175553 C/T cg17467752 chr17:38218738 THRA 0.77 12.42 0.56 2.3e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg23791538 chr6:167370224 RNASET2 -0.37 -5.74 -0.3 2.1e-8 Crohn's disease; LUSC cis rs2677744 0.626 rs868547 chr15:91498760 G/A cg23684204 chr15:91497937 RCCD1 0.55 7.74 0.39 1.18e-13 Attention deficit hyperactivity disorder; LUSC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -14.21 -0.61 3.52e-36 Hemoglobin concentration; LUSC cis rs7512552 0.839 rs2867894 chr1:150452912 T/A cg15654264 chr1:150340011 RPRD2 0.59 9.69 0.47 1.03e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.7 10.48 0.5 2.07e-22 IgG glycosylation; LUSC cis rs7923609 0.811 rs3847326 chr10:65331859 A/G cg01631684 chr10:65280961 REEP3 0.4 5.92 0.31 7.83e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg11247378 chr22:39784982 NA 0.65 12.88 0.58 4.13e-31 Intelligence (multi-trait analysis); LUSC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.37 6.03 0.31 4.32e-9 Self-reported allergy; LUSC cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.93e-16 Menopause (age at onset); LUSC cis rs1538970 0.962 rs2487442 chr1:45857176 C/G cg05343316 chr1:45956843 TESK2 -0.58 -8.27 -0.41 3.15e-15 Platelet count; LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg11766577 chr21:47581405 C21orf56 -0.55 -8.48 -0.42 7.46e-16 Testicular germ cell tumor; LUSC cis rs11785400 0.642 rs4256574 chr8:143725705 C/T cg10596483 chr8:143751796 JRK 0.52 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.3 0.53 2.82e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg24829409 chr8:58192753 C8orf71 -0.6 -7.41 -0.38 1.03e-12 Developmental language disorder (linguistic errors); LUSC cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg12573674 chr2:1569213 NA -0.63 -8.74 -0.43 1.15e-16 IgG glycosylation; LUSC cis rs7953508 0.711 rs11107116 chr12:93978504 G/T cg18151635 chr12:93972918 NA -0.58 -8.03 -0.4 1.63e-14 Pubertal anthropometrics; LUSC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg07716408 chr11:68623521 NA -0.31 -5.94 -0.31 7.27e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg22903657 chr4:1355424 KIAA1530 -0.37 -6.14 -0.32 2.4e-9 Longevity; LUSC cis rs8005677 0.962 rs10130756 chr14:23396600 C/G cg00579484 chr14:23475993 C14orf93 0.39 5.85 0.3 1.2e-8 Cognitive ability (multi-trait analysis); LUSC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs7786877 0.626 rs11983745 chr7:100223678 T/C cg20848291 chr7:100343083 ZAN -0.58 -7.02 -0.36 1.21e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs929354 0.772 rs6969244 chr7:157004012 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.25 0.59 1.76e-32 Body mass index; LUSC cis rs5762813 0.524 rs5762835 chr22:29230754 A/G cg02153584 chr22:29168773 CCDC117 0.54 6.36 0.33 6.54e-10 Hematocrit;Hemoglobin concentration; LUSC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 11.98 0.55 9e-28 Hip circumference adjusted for BMI; LUSC cis rs1801251 1.000 rs895430 chr2:233725483 C/A cg08000102 chr2:233561755 GIGYF2 -0.69 -11.49 -0.53 5.48e-26 Coronary artery disease; LUSC cis rs7617773 0.780 rs4479622 chr3:48338173 C/T cg11946769 chr3:48343235 NME6 0.88 14.29 0.62 1.69e-36 Coronary artery disease; LUSC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg12463550 chr7:65579703 CRCP 0.52 7.61 0.38 2.85e-13 Aortic root size; LUSC cis rs1348850 0.645 rs10181259 chr2:178428256 C/A cg22681709 chr2:178499509 PDE11A -0.37 -5.66 -0.3 3.34e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs8114671 0.967 rs1415774 chr20:33765616 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -5.75 -0.3 2.06e-8 Height; LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -6.3 -0.33 9.26e-10 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg04369109 chr6:150039330 LATS1 -0.58 -8.56 -0.42 4.25e-16 Lung cancer; LUSC cis rs16949788 1.000 rs9806474 chr15:66646513 C/T cg08120210 chr15:66682733 MAP2K1 -0.58 -5.88 -0.31 9.73e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs300703 0.935 rs12714403 chr2:273070 A/G cg21211680 chr2:198530 NA 0.68 7.21 0.37 3.7e-12 Blood protein levels; LUSC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg02788857 chr8:22132959 PIWIL2 0.39 7.55 0.38 4.3e-13 Hypertriglyceridemia; LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg00166722 chr3:10149974 C3orf24 0.59 7.73 0.39 1.25e-13 Alzheimer's disease; LUSC cis rs11650494 0.908 rs77488129 chr17:47448970 G/A cg08112188 chr17:47440006 ZNF652 1.4 11.42 0.53 1.02e-25 Prostate cancer; LUSC trans rs6952808 0.789 rs35729895 chr7:1885069 C/T cg24247370 chr13:99142703 STK24 -0.35 -6.2 -0.32 1.63e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 1.000 rs57378064 chr8:58169844 C/G cg24829409 chr8:58192753 C8orf71 -0.57 -7.23 -0.37 3.27e-12 Developmental language disorder (linguistic errors); LUSC cis rs17253792 0.731 rs74823888 chr14:56049800 T/C cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg13298116 chr11:62369859 EML3;MTA2 0.59 9.58 0.46 2.25e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs796364 0.806 rs10445791 chr2:201078307 C/T cg23649088 chr2:200775458 C2orf69 -0.54 -6.37 -0.33 6.23e-10 Schizophrenia; LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg27170947 chr2:26402098 FAM59B -0.7 -10.69 -0.5 3.92e-23 Gut microbiome composition (summer); LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg09033563 chr22:24373618 LOC391322 -0.6 -9.42 -0.46 7.85e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4845570 1.000 rs4845570 chr1:151759104 C/T cg07092448 chr1:151763213 TDRKH 1.23 14.14 0.61 6.53e-36 Coronary artery disease; LUSC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg06558623 chr16:89946397 TCF25 1.08 9.74 0.47 6.73e-20 Skin colour saturation; LUSC cis rs6696846 0.765 rs3738155 chr1:205074424 C/T cg21643547 chr1:205240462 TMCC2 -0.42 -7.65 -0.39 2.15e-13 Red blood cell count; LUSC cis rs11098499 0.908 rs11729050 chr4:120300066 T/C cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg01475377 chr6:109611718 NA -0.45 -8.27 -0.41 3.13e-15 Reticulocyte fraction of red cells; LUSC cis rs708547 0.581 rs6554400 chr4:57805306 A/C cg25525207 chr4:57843836 C4orf14;POLR2B 0.42 6.24 0.32 1.31e-9 Response to bleomycin (chromatid breaks); LUSC cis rs2617583 0.509 rs4738 chr5:1461568 C/T cg13982541 chr5:1466431 LPCAT1 0.41 5.76 0.3 1.93e-8 Breast cancer; LUSC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg12516959 chr21:47718080 NA -0.38 -6.15 -0.32 2.25e-9 Testicular germ cell tumor; LUSC cis rs12476592 0.636 rs196123 chr2:63841712 T/C cg10828910 chr2:63850056 LOC388955 0.54 6.29 0.33 9.71e-10 Childhood ear infection; LUSC trans rs877282 0.898 rs11253348 chr10:765852 C/T cg22713356 chr15:30763199 NA 1.07 14.15 0.61 6.32e-36 Uric acid levels; LUSC cis rs921968 0.565 rs6436082 chr2:219639430 A/G cg02176678 chr2:219576539 TTLL4 -0.55 -9.78 -0.47 4.92e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs12824058 1.000 rs12824058 chr12:130804334 A/G cg23887609 chr12:130822674 PIWIL1 0.53 8.11 0.41 9.87e-15 Menopause (age at onset); LUSC cis rs3008870 1.000 rs2985794 chr1:67425311 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.34 0.64 1.46e-40 Lymphocyte percentage of white cells; LUSC trans rs7091957 1.000 rs7091957 chr10:134439478 C/T cg13309027 chr11:47870224 NUP160 -0.44 -6.77 -0.35 5.72e-11 Gait speed in old age; LUSC cis rs7640424 0.502 rs326359 chr3:107820619 G/A cg09227934 chr3:107805635 CD47 0.54 9.9 0.48 1.98e-20 Body mass index; LUSC cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg09184832 chr6:79620586 NA -0.43 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); LUSC cis rs12220238 1.000 rs7905536 chr10:75997209 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.58 6.65 0.34 1.22e-10 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2274459 0.841 rs13214874 chr6:33686368 G/A cg06253072 chr6:33679850 C6orf125 0.5 5.89 0.31 9.29e-9 Obesity (extreme); LUSC cis rs3741151 1.000 rs57893472 chr11:73042826 C/T cg17517138 chr11:73019481 ARHGEF17 1.0 9.24 0.45 2.95e-18 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg01028140 chr2:1542097 TPO -0.49 -6.9 -0.35 2.56e-11 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs2637266 1.000 rs7914880 chr10:78363693 A/G cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.61e-12 Pulmonary function; LUSC trans rs62238980 0.614 rs76363976 chr22:32383968 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs614226 0.935 rs2235222 chr12:120892193 G/C cg21053147 chr12:120880522 NA 0.5 5.97 0.31 5.92e-9 Type 1 diabetes nephropathy; LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg04944784 chr2:26401820 FAM59B -0.61 -7.86 -0.4 5.38e-14 Gut microbiome composition (summer); LUSC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg03806693 chr22:41940476 POLR3H -0.92 -13.2 -0.59 2.68e-32 Vitiligo; LUSC cis rs6582630 0.547 rs1589388 chr12:38416025 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.07e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg12560992 chr17:57184187 TRIM37 0.9 17.69 0.7 6.85e-50 Intelligence (multi-trait analysis); LUSC cis rs2637266 1.000 rs2579750 chr10:78340260 C/G cg18941641 chr10:78392320 NA -0.38 -7.02 -0.36 1.25e-11 Pulmonary function; LUSC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg07424592 chr7:64974309 NA 0.68 6.14 0.32 2.29e-9 Diabetic kidney disease; LUSC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg10523679 chr1:76189770 ACADM -0.79 -11.02 -0.52 2.62e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs56146971 0.763 rs34854034 chr14:91870677 A/G cg10511902 chr14:91842949 CCDC88C 0.43 5.69 0.3 2.8e-8 Alzheimer disease and age of onset; LUSC cis rs6669919 0.553 rs7546343 chr1:211671801 C/T cg10512769 chr1:211675356 NA -0.3 -7.03 -0.36 1.14e-11 Intelligence (multi-trait analysis); LUSC cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.42 -7.79 -0.39 8.41e-14 Monocyte percentage of white cells; LUSC trans rs6832769 0.621 rs10033028 chr4:56519876 C/G cg25365783 chr7:108166722 PNPLA8 -0.36 -6.4 -0.33 5.12e-10 Personality dimensions; LUSC cis rs1371867 0.817 rs1788185 chr8:101335529 T/C cg00191853 chr8:101177733 SPAG1 -0.41 -6.64 -0.34 1.24e-10 Atrioventricular conduction; LUSC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg02079420 chr8:82753780 SNX16 0.39 6.03 0.31 4.24e-9 Diastolic blood pressure; LUSC cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg05855489 chr10:104503620 C10orf26 0.52 8.03 0.4 1.63e-14 Arsenic metabolism; LUSC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.65 -0.39 2.24e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg13683864 chr3:40499215 RPL14 -1.11 -21.36 -0.76 2.03e-64 Renal cell carcinoma; LUSC cis rs6987853 0.688 rs2923433 chr8:42418723 T/C cg09913449 chr8:42400586 C8orf40 0.5 8.46 0.42 8.67e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs6700896 0.931 rs1805096 chr1:66102257 C/T cg04111102 chr1:66153794 NA 0.31 6.85 0.35 3.57e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10170846 0.893 rs10932967 chr2:223544111 C/T cg25565276 chr2:223520875 FARSB 0.6 8.91 0.44 3.28e-17 Schizophrenia (inflammation and infection response interaction); LUSC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg20607287 chr7:12443886 VWDE -0.65 -6.32 -0.33 8.15e-10 Coronary artery disease; LUSC cis rs1801251 0.963 rs13021246 chr2:233623111 T/C cg25237894 chr2:233734115 C2orf82 0.36 6.74 0.35 7.17e-11 Coronary artery disease; LUSC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg10621924 chr7:39171070 POU6F2 0.43 6.56 0.34 2.01e-10 IgG glycosylation; LUSC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg06238570 chr21:40685208 BRWD1 0.49 7.48 0.38 6.56e-13 Cognitive function; LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg03354898 chr7:1950403 MAD1L1 -0.34 -6.52 -0.34 2.53e-10 Bipolar disorder and schizophrenia; LUSC trans rs2386661 0.547 rs11259582 chr10:5646767 C/T cg11398623 chr21:37499189 NA 0.27 6.17 0.32 2.01e-9 Breast cancer; LUSC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg11871910 chr12:69753446 YEATS4 0.63 9.14 0.45 6.19e-18 Cerebrospinal fluid biomarker levels; LUSC cis rs3857536 0.740 rs4710572 chr6:66890361 C/A cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs7927771 0.725 rs11570094 chr11:47359706 A/C cg20307385 chr11:47447363 PSMC3 0.52 6.44 0.33 4.26e-10 Subjective well-being; LUSC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg16049864 chr8:95962084 TP53INP1 0.6 11.14 0.52 1.03e-24 Type 2 diabetes; LUSC cis rs10197940 0.532 rs13425170 chr2:152387112 A/C cg19508488 chr2:152266495 RIF1 0.55 7.33 0.37 1.74e-12 Lung cancer; LUSC cis rs4727027 0.933 rs6955564 chr7:148866173 A/G cg23583168 chr7:148888333 NA -0.82 -14.25 -0.61 2.46e-36 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2273669 0.667 rs78714994 chr6:109350351 G/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg16520312 chr17:43971471 MAPT;LOC100128977 -0.37 -6.25 -0.32 1.23e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9560113 0.881 rs9560111 chr13:112181289 C/T cg14154082 chr13:112174009 NA 0.38 7.88 0.4 4.53e-14 Menarche (age at onset); LUSC cis rs7772486 0.776 rs2265467 chr6:146218339 T/A cg05347473 chr6:146136440 FBXO30 0.48 8.2 0.41 5.16e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg08999081 chr20:33150536 PIGU -0.38 -6.86 -0.35 3.34e-11 Height; LUSC cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg04455712 chr21:45112962 RRP1B -0.48 -9.09 -0.45 8.99e-18 Mean corpuscular volume; LUSC cis rs9394152 0.845 rs4713632 chr6:33472990 G/T cg13560919 chr6:33536144 NA 0.6 10.63 0.5 6.18e-23 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.95 0.31 6.59e-9 Intelligence (multi-trait analysis); LUSC cis rs9815354 0.670 rs73073238 chr3:42014325 G/C cg03022575 chr3:42003672 ULK4 0.82 8.44 0.42 1.01e-15 Pulse pressure;Diastolic blood pressure; LUSC trans rs7495211 0.529 rs8040797 chr15:98624483 G/C cg08901157 chr15:56033728 PRTG 0.36 6.34 0.33 7.34e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs854765 0.624 rs4925116 chr17:17731200 A/G cg16928487 chr17:17741425 SREBF1 0.47 9.21 0.45 3.57e-18 Total body bone mineral density; LUSC cis rs5769707 0.935 rs739239 chr22:50050468 G/A cg20744362 chr22:50050164 C22orf34 0.4 8.29 0.41 2.75e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4474465 1.000 rs7131199 chr11:78192148 T/G cg27205649 chr11:78285834 NARS2 -0.55 -6.3 -0.33 9.57e-10 Alzheimer's disease (survival time); LUSC trans rs11098499 1.000 rs11098499 chr4:120187611 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.44 6.02 0.31 4.65e-9 Corneal astigmatism; LUSC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg05776053 chr2:74358815 NA 0.45 7.12 0.36 6.54e-12 Gestational age at birth (maternal effect); LUSC cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg22681709 chr2:178499509 PDE11A -0.57 -11.33 -0.53 2.19e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.81 -11.86 -0.54 2.67e-27 Multiple sclerosis; LUSC cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg08999081 chr20:33150536 PIGU 0.51 10.3 0.49 8.71e-22 Glomerular filtration rate (creatinine); LUSC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg11812906 chr14:75593930 NEK9 0.67 11.64 0.54 1.58e-26 Height; LUSC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg14784868 chr12:69753453 YEATS4 0.82 14.29 0.62 1.77e-36 Blood protein levels; LUSC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg05973401 chr12:123451056 ABCB9 0.54 6.68 0.34 1.01e-10 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs752010 0.905 rs2038977 chr1:42094659 A/G cg06885757 chr1:42089581 HIVEP3 0.48 9.83 0.47 3.32e-20 Lupus nephritis in systemic lupus erythematosus; LUSC trans rs12310956 0.532 rs7306007 chr12:33975209 C/G cg26384229 chr12:38710491 ALG10B 0.7 10.82 0.51 1.41e-23 Morning vs. evening chronotype; LUSC cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg03146154 chr1:46216737 IPP -0.58 -8.42 -0.42 1.11e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2018683 0.677 rs12531456 chr7:28970611 A/C cg19402173 chr7:128379420 CALU -0.47 -7.08 -0.36 8.76e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs6503525 0.628 rs62068171 chr17:38103242 G/A cg24910161 chr17:38119198 GSDMA -0.29 -6.46 -0.33 3.76e-10 Asthma; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg25767906 chr1:53392781 SCP2 0.48 8.63 0.43 2.55e-16 Monocyte count; LUSC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg22166914 chr1:53195759 ZYG11B -0.69 -12.08 -0.55 4.17e-28 Monocyte count; LUSC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg22862634 chr11:62369728 EML3;MTA2 0.49 7.09 0.36 8.23e-12 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg08219700 chr8:58056026 NA 0.46 6.03 0.31 4.26e-9 Developmental language disorder (linguistic errors); LUSC cis rs2486288 0.656 rs11637364 chr15:45579238 C/T cg09092052 chr15:45571596 NA 0.45 6.18 0.32 1.85e-9 Glomerular filtration rate; LUSC cis rs7727544 0.716 rs7701414 chr5:131585958 A/G cg04518342 chr5:131593106 PDLIM4 0.36 6.71 0.34 8.3e-11 Blood metabolite levels; LUSC cis rs10504073 0.647 rs4873312 chr8:49991145 A/G cg00325661 chr8:49890786 NA 0.62 9.95 0.48 1.3e-20 Blood metabolite ratios; LUSC trans rs11098499 0.865 rs9994730 chr4:120381564 A/C cg25214090 chr10:38739885 LOC399744 0.56 8.16 0.41 7.08e-15 Corneal astigmatism; LUSC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.61 9.48 0.46 4.79e-19 Total body bone mineral density; LUSC cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg00677455 chr12:58241039 CTDSP2 0.7 10.53 0.5 1.45e-22 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.84 -0.54 3.05e-27 Chronic sinus infection; LUSC cis rs7582720 0.943 rs72936866 chr2:203787120 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6577655 0.517 rs6996991 chr8:135589255 G/A cg17885191 chr8:135476712 NA 0.61 7.97 0.4 2.61e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg06740227 chr12:86229804 RASSF9 0.45 7.23 0.37 3.37e-12 Major depressive disorder; LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC trans rs7829975 0.626 rs907183 chr8:8729761 C/G cg27411982 chr8:10470053 RP1L1 -0.47 -7.2 -0.37 4.06e-12 Mood instability; LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg27535305 chr1:53392650 SCP2 0.36 6.78 0.35 5.47e-11 Monocyte count; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg05665937 chr4:1216051 CTBP1 -0.37 -5.79 -0.3 1.65e-8 Obesity-related traits; LUSC cis rs7587476 0.784 rs62202001 chr2:215690359 C/G cg04004882 chr2:215674386 BARD1 0.48 6.37 0.33 6.34e-10 Neuroblastoma; LUSC cis rs4285028 0.948 rs13067270 chr3:121673901 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.67 -0.47 1.19e-19 Multiple sclerosis; LUSC cis rs34779708 0.931 rs4351760 chr10:35280254 A/G cg03585969 chr10:35415529 CREM 0.65 9.25 0.45 2.78e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9814567 0.806 rs4955534 chr3:134319723 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.39 -0.56 2.93e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3008870 1.000 rs1925412 chr1:67405057 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.18 0.64 6e-40 Lymphocyte percentage of white cells; LUSC cis rs9296092 0.560 rs9469502 chr6:33526648 G/A cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg17724175 chr1:150552817 MCL1 0.37 6.64 0.34 1.25e-10 Tonsillectomy; LUSC cis rs4969178 0.965 rs3744217 chr17:76400258 G/A cg20026190 chr17:76395443 PGS1 0.45 8.06 0.4 1.4e-14 HDL cholesterol levels; LUSC trans rs61931739 0.649 rs1068864 chr12:33733119 A/C cg26384229 chr12:38710491 ALG10B 0.43 6.18 0.32 1.9e-9 Morning vs. evening chronotype; LUSC cis rs4409675 0.576 rs7520860 chr1:28232952 C/A cg23691781 chr1:28212827 C1orf38 0.32 7.65 0.39 2.21e-13 Corneal astigmatism; LUSC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg26335602 chr6:28129616 ZNF389 0.46 6.3 0.33 9.49e-10 Parkinson's disease; LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 14.31 0.62 1.51e-36 Platelet count; LUSC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21310689 chr19:55865288 COX6B2 0.71 6.09 0.32 3.19e-9 Cognitive performance; LUSC cis rs2479724 0.636 rs1192238 chr6:41803836 C/T cg17623882 chr6:41773611 USP49 0.53 7.29 0.37 2.26e-12 Menarche (age at onset); LUSC cis rs9457247 0.638 rs239933 chr6:167413230 A/G cg25258033 chr6:167368657 RNASET2 0.36 5.73 0.3 2.27e-8 Crohn's disease; LUSC cis rs2404602 0.692 rs12910734 chr15:77149931 A/G cg26408565 chr15:76604113 ETFA -0.48 -7.58 -0.38 3.4e-13 Blood metabolite levels; LUSC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg24250549 chr1:154909240 PMVK 0.59 9.69 0.47 9.63e-20 Prostate cancer; LUSC cis rs6693567 0.565 rs543179 chr1:150274610 G/A cg15654264 chr1:150340011 RPRD2 -0.45 -7.41 -0.38 1.06e-12 Migraine; LUSC cis rs250677 0.917 rs36066 chr5:148419771 A/G cg05026186 chr5:148520876 ABLIM3 -0.39 -5.93 -0.31 7.76e-9 Breast cancer; LUSC cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg23029597 chr12:123009494 RSRC2 -0.72 -9.33 -0.45 1.51e-18 Body mass index; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs3126085 0.597 rs12047544 chr1:152169922 C/T cg26876637 chr1:152193138 HRNR 0.47 6.6 0.34 1.66e-10 Atopic dermatitis; LUSC cis rs887829 0.570 rs6736508 chr2:234595747 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.41 -0.33 5.08e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19487718 chr4:185747708 ACSL1 0.42 6.02 0.31 4.54e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg16405210 chr4:1374714 KIAA1530 -0.49 -7.04 -0.36 1.11e-11 Obesity-related traits; LUSC trans rs9929218 0.551 rs6499193 chr16:68727069 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 23.49 0.79 1.05e-72 Colorectal cancer; LUSC cis rs3782089 1.000 rs11602375 chr11:65296540 C/T cg21890820 chr11:65308645 LTBP3 1.41 9.74 0.47 7e-20 Height; LUSC cis rs6681460 0.565 rs2147776 chr1:67107403 T/C cg02459107 chr1:67143332 SGIP1 0.43 7.98 0.4 2.29e-14 Presence of antiphospholipid antibodies; LUSC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg00933542 chr6:150070202 PCMT1 0.33 6.91 0.35 2.42e-11 Lung cancer; LUSC cis rs12450688 1 rs12450688 chr17:38144229 G/A cg17467752 chr17:38218738 THRA -0.71 -11.3 -0.53 2.64e-25 Sum eosinophil basophil counts; LUSC cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg00071950 chr4:10020882 SLC2A9 0.58 9.57 0.46 2.5e-19 Bone mineral density; LUSC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg08999081 chr20:33150536 PIGU 0.43 7.83 0.39 6.51e-14 Coronary artery disease; LUSC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg13206674 chr6:150067644 NUP43 -0.61 -8.99 -0.44 1.82e-17 Lung cancer; LUSC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg20887711 chr4:1340912 KIAA1530 0.43 6.56 0.34 2.05e-10 Obesity-related traits; LUSC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg07701084 chr6:150067640 NUP43 0.48 7.21 0.37 3.75e-12 Testicular germ cell tumor; LUSC cis rs28655083 0.957 rs7185514 chr16:77070129 T/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.41 -6.46 -0.33 3.79e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs16937 0.711 rs10751429 chr1:205107478 C/T cg00857998 chr1:205179979 DSTYK 0.47 6.59 0.34 1.71e-10 Schizophrenia; LUSC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg17718321 chr1:152188247 HRNR -0.38 -6.8 -0.35 4.71e-11 Inflammatory skin disease; LUSC cis rs9399401 0.884 rs263179 chr6:142863888 T/C cg03128060 chr6:142623767 GPR126 0.33 6.07 0.32 3.42e-9 Chronic obstructive pulmonary disease; LUSC cis rs10504073 0.605 rs62507176 chr8:49930321 G/A cg00325661 chr8:49890786 NA 0.7 11.06 0.52 1.95e-24 Blood metabolite ratios; LUSC cis rs4319547 0.774 rs7959238 chr12:123131498 A/T cg23029597 chr12:123009494 RSRC2 -0.61 -8.67 -0.43 1.9e-16 Body mass index; LUSC cis rs7267979 0.934 rs2261753 chr20:25262291 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.74 0.75 5.32e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3820068 0.608 rs12740492 chr1:16048951 A/T cg17385448 chr1:15911702 AGMAT 0.34 5.68 0.3 2.91e-8 Systolic blood pressure; LUSC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg18876405 chr7:65276391 NA -0.59 -9.57 -0.46 2.43e-19 Aortic root size; LUSC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg22508957 chr16:3507546 NAT15 0.84 10.68 0.5 4.13e-23 Tuberculosis; LUSC cis rs11105298 0.891 rs10858900 chr12:89925081 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.06e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs10504229 0.679 rs16921676 chr8:58052386 G/T cg08219700 chr8:58056026 NA 0.51 6.49 0.33 3.08e-10 Developmental language disorder (linguistic errors); LUSC cis rs9646944 0.578 rs13418548 chr2:102917239 C/T cg20060108 chr2:102954350 IL1RL1 0.46 5.88 0.31 9.99e-9 Blood protein levels; LUSC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.11 0.41 9.55e-15 Homoarginine levels; LUSC cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13347679 chr3:9774065 BRPF1 -0.41 -5.97 -0.31 5.9e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg16797656 chr11:68205561 LRP5 0.44 8.12 0.41 9.31e-15 Total body bone mineral density; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg25551287 chr1:205649424 SLC45A3 0.44 6.04 0.31 4.2e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg02475777 chr4:1388615 CRIPAK -0.42 -6.17 -0.32 1.96e-9 Obesity-related traits; LUSC cis rs73198271 0.740 rs1039910 chr8:8648066 T/C cg15556689 chr8:8085844 FLJ10661 -0.47 -6.28 -0.32 1.06e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9549367 0.713 rs2480949 chr13:113853149 T/C cg18105134 chr13:113819100 PROZ 0.65 9.62 0.47 1.67e-19 Platelet distribution width; LUSC trans rs11992162 0.591 rs4240678 chr8:11802426 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.63 -0.34 1.39e-10 Monocyte count; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg06238570 chr21:40685208 BRWD1 0.37 5.64 0.3 3.57e-8 Cognitive function; LUSC cis rs614226 1.000 rs616157 chr12:120925795 T/C cg21053147 chr12:120880522 NA 0.52 6.39 0.33 5.53e-10 Type 1 diabetes nephropathy; LUSC cis rs1775715 0.966 rs1755066 chr10:32309160 C/G cg18675610 chr10:32216311 ARHGAP12 -0.27 -5.71 -0.3 2.5e-8 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs6502050 0.835 rs6502077 chr17:80122966 G/C cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC trans rs11098499 0.865 rs1112817 chr4:120297800 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg02423579 chr7:2872169 GNA12 -0.39 -6.16 -0.32 2.06e-9 Height; LUSC cis rs9612 0.950 rs346546 chr19:44256910 T/C cg08581076 chr19:44259116 C19orf61 0.53 6.71 0.34 8.22e-11 Exhaled nitric oxide output; LUSC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg24250549 chr1:154909240 PMVK 0.49 7.47 0.38 6.99e-13 Prostate cancer; LUSC cis rs3820068 0.705 rs11589076 chr1:15827027 C/T cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.3 1.45e-8 Systolic blood pressure; LUSC cis rs11690935 0.921 rs7594711 chr2:172895637 T/G cg13550731 chr2:172543902 DYNC1I2 -0.81 -13.2 -0.59 2.61e-32 Schizophrenia; LUSC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg05347473 chr6:146136440 FBXO30 0.52 8.87 0.44 4.4e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs7577851 0.715 rs7605572 chr2:69646504 G/A cg10773587 chr2:69614142 GFPT1 0.58 7.06 0.36 9.94e-12 Parkinson's disease (age of onset); LUSC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg24578937 chr1:2090814 PRKCZ -0.43 -9.54 -0.46 3.18e-19 Height; LUSC cis rs258324 0.720 rs154663 chr16:89726035 T/C cg26513180 chr16:89883248 FANCA -0.75 -6.64 -0.34 1.28e-10 Height; LUSC trans rs587847 0.507 rs12593565 chr15:37807627 G/A cg18296784 chr11:116147929 NA -0.35 -6.37 -0.33 6.39e-10 Intraocular pressure; LUSC cis rs1448094 0.967 rs1374995 chr12:86341764 A/G cg02569458 chr12:86230093 RASSF9 0.42 6.83 0.35 4.04e-11 Major depressive disorder; LUSC cis rs10744422 0.858 rs2292136 chr12:123339344 A/G cg25930673 chr12:123319894 HIP1R -0.72 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.64 -0.34 1.28e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg06145435 chr7:1022769 CYP2W1 -0.32 -5.64 -0.3 3.56e-8 Bronchopulmonary dysplasia; LUSC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg11764359 chr7:65958608 NA 0.81 13.41 0.59 4.23e-33 Aortic root size; LUSC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.54 0.38 4.58e-13 Parkinson's disease; LUSC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs4363385 0.510 rs6661063 chr1:153036048 C/A cg00922841 chr1:152955080 SPRR1A -0.36 -6.25 -0.32 1.22e-9 Inflammatory skin disease; LUSC cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg03647239 chr10:116582469 FAM160B1 0.45 7.36 0.37 1.46e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7712401 0.601 rs246274 chr5:122280803 A/C cg19077854 chr5:122220652 SNX24 0.41 9.17 0.45 4.86e-18 Mean platelet volume; LUSC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.09 -0.36 8.12e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.7 0.34 8.68e-11 Menopause (age at onset); LUSC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg23711669 chr6:146136114 FBXO30 0.81 14.78 0.63 2.11e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9807841 0.670 rs10405617 chr19:10752968 C/T cg17710535 chr19:10819994 QTRT1 -0.41 -6.6 -0.34 1.63e-10 Inflammatory skin disease; LUSC cis rs1670533 1.000 rs2290410 chr4:1052078 A/T cg27284194 chr4:1044797 NA 0.56 8.07 0.4 1.3e-14 Recombination rate (females); LUSC trans rs7819412 0.775 rs34094119 chr8:10935898 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.34 -0.37 1.63e-12 Triglycerides; LUSC cis rs4319547 0.695 rs113841747 chr12:122886088 G/T cg05707623 chr12:122985044 ZCCHC8 0.67 8.19 0.41 5.44e-15 Body mass index; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg24449302 chr15:66679100 MAP2K1 -0.42 -5.95 -0.31 6.73e-9 Height; LUSC cis rs5753618 0.509 rs1034589 chr22:31579233 C/T cg22777020 chr22:31556080 RNF185 -0.47 -6.04 -0.31 4.07e-9 Colorectal cancer; LUSC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg08392591 chr16:89556376 ANKRD11 0.5 7.59 0.38 3.27e-13 Multiple myeloma (IgH translocation); LUSC cis rs427941 0.632 rs201508 chr7:101764199 T/G cg06246474 chr7:101738831 CUX1 0.39 6.32 0.33 8.21e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg05294307 chr14:35346193 BAZ1A -0.61 -7.44 -0.38 8.85e-13 Psoriasis; LUSC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg22800045 chr5:56110881 MAP3K1 0.79 10.33 0.49 6.92e-22 Initial pursuit acceleration; LUSC cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg16586182 chr3:47516702 SCAP 0.52 7.93 0.4 3.31e-14 Colorectal cancer; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg09302904 chr17:62340561 TEX2 0.5 6.03 0.31 4.37e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg07701084 chr6:150067640 NUP43 0.58 8.69 0.43 1.68e-16 Lung cancer; LUSC cis rs2898290 0.617 rs13278965 chr8:11466745 A/T cg21775007 chr8:11205619 TDH 0.42 6.13 0.32 2.45e-9 Systolic blood pressure; LUSC cis rs1215050 0.846 rs1839903 chr4:98791414 C/T cg05340658 chr4:99064831 C4orf37 0.41 6.24 0.32 1.31e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9399135 0.967 rs13191501 chr6:135366880 T/C cg24558204 chr6:135376177 HBS1L 0.57 8.77 0.43 9.11e-17 Red blood cell count; LUSC cis rs7592578 0.766 rs62182885 chr2:191437024 A/G cg10560079 chr2:191398806 TMEM194B -0.71 -8.42 -0.42 1.11e-15 Diastolic blood pressure; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.2 0.45 4.07e-18 Prudent dietary pattern; LUSC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg13206674 chr6:150067644 NUP43 -0.59 -9.37 -0.46 1.1e-18 Lung cancer; LUSC trans rs208520 0.690 rs207091 chr6:66799847 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.61 -0.69 1.49e-49 Exhaled nitric oxide output; LUSC cis rs240764 0.604 rs1336242 chr6:101199634 C/T cg09795085 chr6:101329169 ASCC3 0.43 6.2 0.32 1.71e-9 Neuroticism; LUSC cis rs7903847 0.642 rs11189172 chr10:99135215 T/C cg08345082 chr10:99160200 RRP12 -0.41 -7.98 -0.4 2.34e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 11.82 0.54 3.71e-27 Chronic sinus infection; LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.55 0.6 1.23e-33 Platelet count; LUSC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12050794 0.671 rs7179427 chr15:72516821 G/A cg16672083 chr15:72433130 SENP8 0.47 7.75 0.39 1.09e-13 Metabolite levels (HVA/MHPG ratio); LUSC cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg00012203 chr2:219082015 ARPC2 -0.76 -13.58 -0.6 9.19e-34 Colorectal cancer; LUSC cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16557308 chr1:52082719 OSBPL9 -0.5 -6.36 -0.33 6.48e-10 Bipolar disorder and schizophrenia; LUSC cis rs727505 1.000 rs28523990 chr7:124436139 C/T cg23710748 chr7:124431027 NA -0.44 -8.03 -0.4 1.65e-14 Lewy body disease; LUSC cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg24812749 chr6:127587940 RNF146 0.91 13.51 0.59 1.7e-33 Breast cancer; LUSC cis rs7799006 0.527 rs6967286 chr7:2212758 C/A cg12823233 chr7:2316876 SNX8 -0.34 -5.79 -0.3 1.65e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11630290 0.592 rs1017531 chr15:64158650 G/A cg12036633 chr15:63758958 NA 0.53 6.73 0.35 7.35e-11 Iris characteristics; LUSC cis rs10089 1.000 rs10478798 chr5:127442394 C/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.86 -0.31 1.12e-8 Ileal carcinoids; LUSC cis rs709400 0.628 rs12889639 chr14:103860206 G/A cg12935359 chr14:103987150 CKB 0.5 7.82 0.39 6.84e-14 Body mass index; LUSC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg17971929 chr21:40555470 PSMG1 -0.49 -7.09 -0.36 7.88e-12 Menarche (age at onset); LUSC cis rs3007168 0.794 rs11850707 chr14:51627074 A/G cg23942311 chr14:51606299 NA 0.36 6.85 0.35 3.64e-11 Cancer; LUSC trans rs12902680 0.641 rs12440603 chr15:46585722 C/T cg04321580 chr8:143696133 ARC -0.4 -6.04 -0.31 4.18e-9 Neuroticism; LUSC cis rs10072221 0.738 rs10065322 chr5:75709413 G/A cg03132911 chr5:75698732 IQGAP2 0.36 6.06 0.31 3.74e-9 Mean platelet volume; LUSC cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg11266682 chr4:10021025 SLC2A9 0.58 10.35 0.49 5.78e-22 Bone mineral density; LUSC cis rs9303542 0.625 rs7225995 chr17:46596268 G/C cg09704116 chr17:46666958 LOC404266 -0.38 -6.87 -0.35 3.12e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg11062466 chr8:58055876 NA 0.68 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs13394619 0.936 rs9789414 chr2:11724684 A/G cg07314298 chr2:11723111 GREB1 -0.59 -10.54 -0.5 1.28e-22 Endometriosis; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg09272869 chr15:68569991 FEM1B 0.41 6.33 0.33 8.04e-10 Schizophrenia; LUSC cis rs4803468 1.000 rs4674 chr19:41930396 A/G cg09537434 chr19:41945824 ATP5SL -0.92 -16.08 -0.66 1.79e-43 Height; LUSC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg13012494 chr21:47604986 C21orf56 0.42 6.3 0.33 9.61e-10 Testicular germ cell tumor; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 11.11 0.52 1.29e-24 Alzheimer's disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08436942 chr4:4249992 TMEM128 -0.41 -6.05 -0.31 3.94e-9 Hepatitis; LUSC cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg25801113 chr15:45476975 SHF 0.35 7.22 0.37 3.5e-12 Uric acid levels; LUSC cis rs2798269 0.668 rs1199938 chr13:22068225 A/G cg18095732 chr13:22033692 ZDHHC20 -0.38 -5.99 -0.31 5.55e-9 PR segment; LUSC trans rs7681440 0.904 rs2870029 chr4:90772057 G/T cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.97 -0.31 6.23e-9 Dementia with Lewy bodies; LUSC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1577917 0.798 rs7772384 chr6:86639680 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg08999081 chr20:33150536 PIGU 0.54 10.96 0.51 4.22e-24 Coronary artery disease; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg05863683 chr7:1912471 MAD1L1 0.31 5.97 0.31 6.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs12900413 0.687 rs34284515 chr15:90308061 T/G cg24249390 chr15:90295951 MESP1 -0.37 -5.87 -0.31 1.03e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg23788917 chr6:8435910 SLC35B3 0.5 7.32 0.37 1.91e-12 Motion sickness; LUSC cis rs6424115 0.830 rs2502994 chr1:24199363 T/C cg10978503 chr1:24200527 CNR2 0.54 13.21 0.59 2.32e-32 Immature fraction of reticulocytes; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.21 0.56 1.29e-28 Prudent dietary pattern; LUSC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.34 -0.41 2.04e-15 Height; LUSC cis rs5771242 0.518 rs5771258 chr22:50675648 C/A cg16473166 chr22:50639996 SELO 0.72 9.64 0.47 1.44e-19 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); LUSC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg23711669 chr6:146136114 FBXO30 0.87 16.53 0.67 2.75e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs1692580 0.870 rs263533 chr1:2163568 C/T cg04315214 chr1:2043799 PRKCZ -0.31 -5.94 -0.31 7.32e-9 Coronary artery disease; LUSC cis rs10979 0.651 rs9321921 chr6:143895053 C/T cg25407410 chr6:143891975 LOC285740 -0.68 -9.47 -0.46 5.22e-19 Hypospadias; LUSC cis rs6494488 0.500 rs72744741 chr15:65050514 T/C cg08069370 chr15:64387884 SNX1 -0.65 -5.91 -0.31 8.23e-9 Coronary artery disease; LUSC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg04414720 chr1:150670196 GOLPH3L 0.51 8.26 0.41 3.47e-15 Tonsillectomy; LUSC cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 12.99 0.58 1.65e-31 Chronic sinus infection; LUSC cis rs12900413 0.603 rs12911871 chr15:90301429 T/C cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs7824557 0.564 rs34964435 chr8:11230206 G/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.85 -0.31 1.14e-8 Retinal vascular caliber; LUSC cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs7568458 0.846 rs6547621 chr2:85774676 G/A cg17127132 chr2:85788382 GGCX 0.45 7.08 0.36 8.6e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7927771 0.524 rs10838769 chr11:47825333 A/G cg20307385 chr11:47447363 PSMC3 -0.45 -6.69 -0.34 9.64e-11 Subjective well-being; LUSC cis rs6495367 1.000 rs28412916 chr15:79378167 A/C cg17916960 chr15:79447300 NA 0.37 6.86 0.35 3.28e-11 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs734999 0.545 rs10910106 chr1:2538886 G/T cg18932078 chr1:2524107 MMEL1 0.32 7.08 0.36 8.45e-12 Ulcerative colitis; LUSC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.49 6.13 0.32 2.44e-9 Schizophrenia; LUSC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg06112835 chr11:68658793 MRPL21 0.52 7.8 0.39 7.84e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg18904891 chr8:8559673 CLDN23 0.6 8.33 0.41 2.08e-15 Obesity-related traits; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg14004847 chr7:1930337 MAD1L1 -0.57 -8.65 -0.43 2.26e-16 Bipolar disorder and schizophrenia; LUSC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg18252515 chr7:66147081 NA -1.23 -13.41 -0.59 4.23e-33 Diabetic kidney disease; LUSC cis rs2692947 0.696 rs1724121 chr2:96808549 T/C cg23100626 chr2:96804247 ASTL 0.27 6.59 0.34 1.72e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg04362960 chr10:104952993 NT5C2 -0.6 -9.33 -0.45 1.52e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6445967 0.689 rs11714574 chr3:58380465 A/T cg23715586 chr3:58305044 RPP14 0.44 8.56 0.42 4.11e-16 Platelet count; LUSC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg05340658 chr4:99064831 C4orf37 0.65 11.1 0.52 1.44e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.692 rs4442773 chr15:77031633 T/C cg26408565 chr15:76604113 ETFA -0.5 -7.93 -0.4 3.26e-14 Blood metabolite levels; LUSC cis rs1451375 0.642 rs6963996 chr7:50559300 T/C cg18232548 chr7:50535776 DDC -0.52 -7.25 -0.37 2.91e-12 Malaria; LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.05 -0.31 3.92e-9 Platelet count; LUSC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22590775 chr19:49891494 CCDC155 0.6 8.8 0.43 7.62e-17 Multiple sclerosis; LUSC cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg06784218 chr1:46089804 CCDC17 0.54 10.91 0.51 6.6e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6542838 0.780 rs981601 chr2:99463882 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.45 -6.38 -0.33 5.77e-10 Fear of minor pain; LUSC cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg27446573 chr6:127587934 RNF146 -0.81 -11.99 -0.55 8.92e-28 Breast cancer; LUSC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg22903471 chr2:27725779 GCKR -0.41 -6.96 -0.36 1.83e-11 Total body bone mineral density; LUSC cis rs1577917 0.696 rs2842603 chr6:86336337 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -9.4 -0.46 8.77e-19 Response to antipsychotic treatment; LUSC cis rs7809950 0.954 rs2189839 chr7:107230026 A/G cg23024343 chr7:107201750 COG5 0.55 8.62 0.43 2.68e-16 Coronary artery disease; LUSC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg27432699 chr2:27873401 GPN1 -0.57 -8.48 -0.42 7.29e-16 Total body bone mineral density; LUSC cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg09184832 chr6:79620586 NA -0.45 -7.34 -0.37 1.67e-12 Intelligence (multi-trait analysis); LUSC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.66 0.3 3.21e-8 Cerebrospinal P-tau181p levels; LUSC trans rs877282 0.945 rs10904550 chr10:774177 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.82 -0.35 4.26e-11 Uric acid levels; LUSC cis rs7615316 0.779 rs9821271 chr3:142034522 A/C cg16271453 chr3:142027066 XRN1 -0.41 -7.13 -0.36 6.32e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3806843 0.576 rs246009 chr5:140338069 A/G cg19875535 chr5:140030758 IK -0.37 -5.71 -0.3 2.5e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg23758822 chr17:41437982 NA 1.05 20.45 0.75 7.54e-61 Menopause (age at onset); LUSC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg17911788 chr17:44343683 NA 0.3 5.82 0.3 1.36e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1395 0.767 rs1821986 chr2:27405835 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.4 -6.68 -0.34 9.89e-11 Blood metabolite levels; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.49 6.09 0.32 3.14e-9 Renal function-related traits (BUN); LUSC cis rs17540621 1.000 rs17540621 chr2:47229839 G/C cg23978866 chr2:47230407 TTC7A -0.97 -6.63 -0.34 1.38e-10 Response to statin therapy; LUSC cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg08999081 chr20:33150536 PIGU 0.53 10.3 0.49 8.6e-22 Coronary artery disease; LUSC cis rs7267979 1.000 rs2258066 chr20:25271326 C/T cg08601574 chr20:25228251 PYGB 0.43 6.53 0.34 2.4e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9322817 0.691 rs4299867 chr6:105325383 G/C cg02098413 chr6:105308735 HACE1 0.27 5.8 0.3 1.52e-8 Thyroid stimulating hormone; LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg05896524 chr21:47604654 C21orf56 -0.57 -8.9 -0.44 3.65e-17 Testicular germ cell tumor; LUSC cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg20503657 chr10:835505 NA 0.9 12.36 0.56 3.66e-29 Eosinophil percentage of granulocytes; LUSC cis rs870825 0.929 rs72689256 chr4:185590174 C/T cg04058563 chr4:185651563 MLF1IP 0.84 11.5 0.53 5.34e-26 Blood protein levels; LUSC cis rs7954584 0.611 rs3887885 chr12:122336486 C/T cg22618164 chr12:122356400 WDR66 0.58 8.79 0.43 7.78e-17 Mean corpuscular volume; LUSC cis rs9322193 0.887 rs4870139 chr6:149896318 T/C cg07701084 chr6:150067640 NUP43 0.52 7.65 0.39 2.12e-13 Lung cancer; LUSC cis rs2625529 0.652 rs2957735 chr15:72265173 T/C cg16672083 chr15:72433130 SENP8 0.48 7.95 0.4 2.86e-14 Red blood cell count; LUSC cis rs9814567 1.000 rs6765505 chr3:134208132 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.85 -14.39 -0.62 7.09e-37 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7103648 0.897 rs2278890 chr11:47399602 G/A cg20307385 chr11:47447363 PSMC3 0.91 15.83 0.65 1.66e-42 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs1775715 0.678 rs2778649 chr10:32146803 C/G cg04359828 chr10:32216031 ARHGAP12 0.42 7.3 0.37 2.15e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11687659 0.515 rs6725611 chr2:191579025 G/A cg11845111 chr2:191398756 TMEM194B -0.44 -5.93 -0.31 7.41e-9 Immature fraction of reticulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24848557 chr11:94227106 MRE11A;ANKRD49 -0.41 -6.04 -0.31 4.22e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9914988 0.943 rs4795459 chr17:27113726 G/C cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4343996 0.521 rs10246895 chr7:3427874 A/G cg21248987 chr7:3385318 SDK1 0.38 6.4 0.33 5.23e-10 Motion sickness; LUSC cis rs4343996 1.000 rs12537549 chr7:3361023 T/G cg21248987 chr7:3385318 SDK1 -0.39 -6.62 -0.34 1.39e-10 Motion sickness; LUSC cis rs10203711 0.932 rs4502365 chr2:239597792 G/A cg14580085 chr2:239553406 NA 0.42 7.15 0.36 5.56e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs1005277 0.579 rs1621040 chr10:38497232 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.51 -0.46 3.89e-19 Extrinsic epigenetic age acceleration; LUSC cis rs2295359 0.892 rs12029362 chr1:67624231 G/A cg03340356 chr1:67600835 NA 0.43 6.65 0.34 1.2e-10 Psoriasis; LUSC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg14895029 chr7:2775587 GNA12 -0.37 -5.76 -0.3 1.91e-8 Height; LUSC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg24250549 chr1:154909240 PMVK 0.64 10.73 0.51 2.82e-23 Prostate cancer; LUSC cis rs28655083 0.509 rs285020 chr16:77099517 C/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.39 6.25 0.32 1.28e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg04871131 chr7:94954202 PON1 -0.4 -6.16 -0.32 2.08e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6546886 0.917 rs11884748 chr2:74248451 A/C cg14702570 chr2:74259524 NA -0.3 -5.65 -0.3 3.37e-8 Dialysis-related mortality; LUSC cis rs7605827 0.930 rs6723785 chr2:15688314 T/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs3768617 0.510 rs3768620 chr1:183092237 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.94 0.51 4.97e-24 Fuchs's corneal dystrophy; LUSC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg11608241 chr8:8085544 FLJ10661 0.39 5.65 0.3 3.53e-8 Joint mobility (Beighton score); LUSC cis rs1865721 0.682 rs35282535 chr18:73141206 G/A cg26385618 chr18:73139727 C18orf62 -0.48 -8.98 -0.44 2.07e-17 Intelligence; LUSC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg09034736 chr1:150693464 HORMAD1 0.44 6.16 0.32 2.05e-9 Melanoma; LUSC cis rs2760061 0.583 rs708123 chr1:228220495 A/G cg02753203 chr1:228287806 NA 1.01 20.87 0.75 1.73e-62 Diastolic blood pressure; LUSC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg00074818 chr8:8560427 CLDN23 0.57 9.8 0.47 4.22e-20 Obesity-related traits; LUSC cis rs2348418 0.715 rs7971717 chr12:28723020 T/C cg13890972 chr12:28721907 NA -0.39 -6.89 -0.35 2.81e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs2404602 0.740 rs34924128 chr15:76965169 T/G cg22467129 chr15:76604101 ETFA -0.43 -6.85 -0.35 3.54e-11 Blood metabolite levels; LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.87 0.31 1.04e-8 Menopause (age at onset); LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2404602 0.684 rs4886819 chr15:76901698 C/T cg23625390 chr15:77176239 SCAPER -0.66 -10.08 -0.48 4.87e-21 Blood metabolite levels; LUSC cis rs9467711 0.591 rs67296946 chr6:26048559 T/G cg16898833 chr6:26189333 HIST1H4D 0.64 6.12 0.32 2.66e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg12011299 chr4:100065546 ADH4 -0.69 -10.72 -0.51 3.17e-23 Alcohol dependence; LUSC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg23283495 chr1:209979779 IRF6 0.65 9.55 0.46 2.85e-19 Cleft lip with or without cleft palate; LUSC cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg26384229 chr12:38710491 ALG10B 0.86 14.72 0.63 3.93e-38 Bladder cancer; LUSC cis rs826838 0.510 rs10506129 chr12:39224242 A/T cg26384229 chr12:38710491 ALG10B 0.78 11.81 0.54 3.85e-27 Heart rate; LUSC trans rs459571 0.920 rs433402 chr9:136898627 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -12.03 -0.55 6.18e-28 Platelet distribution width; LUSC cis rs9916302 0.706 rs11655972 chr17:37407072 C/T cg07936489 chr17:37558343 FBXL20 -0.82 -10.62 -0.5 6.94e-23 Glomerular filtration rate (creatinine); LUSC cis rs708547 1.000 rs2412770 chr4:57794660 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.56 6.81 0.35 4.47e-11 Response to bleomycin (chromatid breaks); LUSC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.64 0.47 1.43e-19 Hip circumference adjusted for BMI; LUSC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg05373962 chr22:49881684 NA -0.43 -10.42 -0.5 3.23e-22 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7267979 1.000 rs6138572 chr20:25435934 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.91 0.7 9.06e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg07703079 chr11:430292 ANO9 0.6 6.54 0.34 2.28e-10 Body mass index; LUSC cis rs34734847 0.898 rs696339 chr12:121169436 A/T cg21892295 chr12:121157589 UNC119B -0.34 -5.99 -0.31 5.41e-9 Mean corpuscular volume; LUSC trans rs1941687 0.563 rs9947894 chr18:31328720 G/T cg27147174 chr7:100797783 AP1S1 0.55 8.57 0.42 3.84e-16 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg04025307 chr7:1156635 C7orf50 0.45 7.07 0.36 9.06e-12 Longevity;Endometriosis; LUSC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg12463550 chr7:65579703 CRCP 0.52 7.54 0.38 4.45e-13 Aortic root size; LUSC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg12963246 chr6:28129442 ZNF389 0.4 5.99 0.31 5.44e-9 Cardiac Troponin-T levels; LUSC cis rs6693567 0.565 rs1313569 chr1:150344171 G/A cg15654264 chr1:150340011 RPRD2 0.46 7.35 0.37 1.5e-12 Migraine; LUSC cis rs9303542 0.625 rs8066613 chr17:46583520 T/A cg09704116 chr17:46666958 LOC404266 -0.36 -6.54 -0.34 2.26e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg12615879 chr12:58013172 SLC26A10 -0.29 -6.1 -0.32 2.92e-9 Multiple sclerosis; LUSC cis rs9660992 0.674 rs17345816 chr1:205262868 A/T cg00857998 chr1:205179979 DSTYK -0.6 -9.12 -0.45 7.46e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10465746 0.746 rs6663949 chr1:84452853 T/C cg10977910 chr1:84465055 TTLL7 0.44 6.43 0.33 4.32e-10 Obesity-related traits; LUSC cis rs7091068 0.616 rs1890657 chr10:95506087 G/A cg20715218 chr10:95462985 C10orf4 0.61 6.58 0.34 1.85e-10 Urinary tract infection frequency; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg06748584 chr17:79520919 C17orf70 -0.45 -6.25 -0.32 1.24e-9 Hepatitis; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg18008202 chr2:131100479 IMP4;CCDC115 0.48 6.0 0.31 5.16e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1775715 0.737 rs2151047 chr10:32102110 G/A cg03015672 chr10:32216066 ARHGAP12 0.35 6.15 0.32 2.23e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7512552 0.803 rs9435997 chr1:150289496 G/A cg15654264 chr1:150340011 RPRD2 -0.66 -11.25 -0.52 4.09e-25 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.72 -0.3 2.37e-8 Depression; LUSC cis rs7615952 0.733 rs13314847 chr3:125644788 C/T cg05084668 chr3:125655381 ALG1L -0.79 -11.95 -0.55 1.26e-27 Blood pressure (smoking interaction); LUSC trans rs10435719 0.647 rs10092605 chr8:11787395 T/G cg06636001 chr8:8085503 FLJ10661 0.54 8.21 0.41 4.82e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg11764359 chr7:65958608 NA -0.51 -6.57 -0.34 1.94e-10 Aortic root size; LUSC cis rs9303401 0.615 rs35288118 chr17:56600748 A/C cg25039879 chr17:56429692 SUPT4H1 0.69 9.08 0.45 9.49e-18 Cognitive test performance; LUSC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg22963979 chr7:1858916 MAD1L1 -0.53 -8.24 -0.41 3.94e-15 Schizophrenia; LUSC trans rs60843830 1.000 rs55936726 chr2:258210 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.35 0.49 5.71e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7589342 0.929 rs6725519 chr2:106445209 A/G cg16077055 chr2:106428750 NCK2 -0.35 -6.7 -0.34 9.06e-11 Addiction; LUSC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15132342 chr17:72978526 NA 0.71 5.95 0.31 6.67e-9 Cognitive performance; LUSC cis rs11650494 0.710 rs11654557 chr17:47390136 A/G cg08112188 chr17:47440006 ZNF652 1.22 10.72 0.51 2.99e-23 Prostate cancer; LUSC cis rs847577 0.630 rs6969384 chr7:97732842 C/T cg24562669 chr7:97807699 LMTK2 0.47 8.29 0.41 2.73e-15 Breast cancer; LUSC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg24531977 chr5:56204891 C5orf35 -1.02 -15.49 -0.65 3.7e-41 Initial pursuit acceleration; LUSC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg19901468 chr14:105411992 AHNAK2 -0.71 -12.34 -0.56 4.44e-29 Rheumatoid arthritis; LUSC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.67 9.45 0.46 5.99e-19 Multiple sclerosis; LUSC cis rs12493885 0.725 rs73158447 chr3:153729792 A/G cg17054900 chr3:154042577 DHX36 -0.68 -7.03 -0.36 1.2e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg22166914 chr1:53195759 ZYG11B 0.56 9.12 0.45 6.96e-18 Monocyte count; LUSC cis rs506338 0.517 rs471618 chr11:64465403 T/C cg19131476 chr11:64387923 NRXN2 0.35 7.64 0.39 2.39e-13 Body mass index;Urate levels; LUSC trans rs1994135 0.692 rs7958788 chr12:33692179 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.58 0.34 1.82e-10 Resting heart rate; LUSC cis rs6138458 1.000 rs227629 chr20:24913551 G/T cg06937882 chr20:24974362 C20orf3 -0.43 -7.41 -0.38 1.04e-12 Blood protein levels; LUSC cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -7.66 -0.39 2.01e-13 Schizophrenia; LUSC trans rs7824557 0.564 rs34964435 chr8:11230206 G/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.61 -0.34 1.48e-10 Retinal vascular caliber; LUSC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg20295408 chr7:1910781 MAD1L1 -0.42 -5.78 -0.3 1.69e-8 Bipolar disorder and schizophrenia; LUSC cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg24692254 chr21:30365293 RNF160 -0.79 -14.42 -0.62 5.61e-37 Dental caries; LUSC cis rs9905704 0.918 rs385793 chr17:56730593 G/A cg12560992 chr17:57184187 TRIM37 0.54 7.72 0.39 1.36e-13 Testicular germ cell tumor; LUSC cis rs11785400 0.793 rs12546978 chr8:143750205 T/A cg24634471 chr8:143751801 JRK -0.49 -7.01 -0.36 1.32e-11 Schizophrenia; LUSC cis rs10788264 0.504 rs4751883 chr10:124018027 A/C cg09507567 chr10:124027408 NA 0.53 9.3 0.45 1.91e-18 Total body bone mineral density; LUSC cis rs9326248 0.581 rs7106437 chr11:116992076 T/C cg01368799 chr11:117014884 PAFAH1B2 0.6 9.34 0.46 1.39e-18 Blood protein levels; LUSC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.24 0.32 1.32e-9 Personality dimensions; LUSC trans rs11039798 0.614 rs116427493 chr11:48776141 C/T cg15704280 chr7:45808275 SEPT13 0.81 7.73 0.39 1.27e-13 Axial length; LUSC cis rs72781680 0.898 rs6712524 chr2:24083925 T/C cg20701182 chr2:24300061 SF3B14 0.55 5.99 0.31 5.31e-9 Lymphocyte counts; LUSC cis rs7937682 0.564 rs11600652 chr11:111754368 A/T cg09085632 chr11:111637200 PPP2R1B 0.96 13.34 0.59 8.01e-33 Primary sclerosing cholangitis; LUSC cis rs7267979 0.966 rs6083817 chr20:25343998 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10464366 0.510 rs62442212 chr7:39146896 A/C cg20302533 chr7:39170763 POU6F2 0.49 8.19 0.41 5.77e-15 IgG glycosylation; LUSC cis rs72792276 1.000 rs72792276 chr5:127364126 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.9 7.8 0.39 7.94e-14 Red cell distribution width; LUSC cis rs6547741 0.935 rs4666004 chr2:27855052 T/A cg12559939 chr2:27858050 GPN1 0.39 6.01 0.31 4.83e-9 Oral cavity cancer; LUSC cis rs926392 0.799 rs742274 chr20:37680944 T/C cg27552599 chr20:37590471 DHX35 0.35 6.14 0.32 2.33e-9 Dialysis-related mortality; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25010622 chr20:32700257 EIF2S2 -0.5 -6.03 -0.31 4.39e-9 Bipolar disorder and schizophrenia; LUSC cis rs1775715 0.737 rs2778661 chr10:32159191 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.76 0.35 6.02e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.45 0.59 2.9e-33 Monocyte percentage of white cells; LUSC cis rs11711311 0.747 rs2895415 chr3:113345565 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.65 -0.3 3.39e-8 IgG glycosylation; LUSC cis rs7189233 0.955 rs72801817 chr16:53474568 C/T cg09728985 chr16:53543985 NA -0.33 -6.05 -0.31 3.84e-9 Intelligence (multi-trait analysis); LUSC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg09796270 chr17:17721594 SREBF1 0.4 7.07 0.36 9.07e-12 Total body bone mineral density; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.15 0.52 9.05e-25 Colorectal cancer; LUSC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21659725 chr3:3221576 CRBN -0.88 -18.04 -0.7 2.96e-51 Intelligence (multi-trait analysis); LUSC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.37 5.68 0.3 2.9e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg26314531 chr2:26401878 FAM59B 0.7 9.08 0.44 9.65e-18 Gut microbiome composition (summer); LUSC cis rs477692 0.673 rs579952 chr10:131356084 A/T cg26102564 chr10:131424627 MGMT -0.38 -5.82 -0.3 1.36e-8 Response to temozolomide; LUSC cis rs10791323 0.660 rs10791330 chr11:133727535 C/T cg15485101 chr11:133734466 NA 0.39 7.36 0.37 1.46e-12 Childhood ear infection; LUSC cis rs1729951 0.545 rs1097288 chr3:136693721 C/T cg12473912 chr3:136751656 NA 0.39 6.89 0.35 2.86e-11 Neuroticism; LUSC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11644478 chr21:40555479 PSMG1 -0.63 -10.21 -0.49 1.75e-21 Cognitive function; LUSC cis rs3784262 0.528 rs6493979 chr15:58338052 C/T cg12031962 chr15:58353849 ALDH1A2 -0.32 -6.01 -0.31 4.84e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg22681709 chr2:178499509 PDE11A -0.51 -9.19 -0.45 4.43e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg22800045 chr5:56110881 MAP3K1 -0.49 -6.38 -0.33 5.82e-10 Coronary artery disease; LUSC cis rs2742417 1.000 rs2742447 chr3:45763977 C/T cg04837898 chr3:45731254 SACM1L -0.34 -5.69 -0.3 2.85e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1784581 0.651 rs1784588 chr6:162390027 T/A cg17173639 chr6:162384350 PARK2 -0.68 -12.36 -0.56 3.68e-29 Itch intensity from mosquito bite; LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg15790184 chr11:494944 RNH1 0.51 5.9 0.31 9.04e-9 Body mass index; LUSC cis rs11758351 1.000 rs2143346 chr6:26198449 C/G cg01420254 chr6:26195488 NA -0.69 -7.28 -0.37 2.38e-12 Gout;Renal underexcretion gout; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg03354898 chr7:1950403 MAD1L1 -0.36 -7.06 -0.36 9.84e-12 Bipolar disorder and schizophrenia; LUSC trans rs45509595 0.659 rs390764 chr6:27782535 C/T cg01620082 chr3:125678407 NA -0.69 -7.05 -0.36 1.06e-11 Breast cancer; LUSC trans rs12310956 0.510 rs7301767 chr12:33886529 A/T cg26384229 chr12:38710491 ALG10B 0.56 8.72 0.43 1.29e-16 Morning vs. evening chronotype; LUSC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg11764359 chr7:65958608 NA 0.79 12.88 0.58 4.22e-31 Aortic root size; LUSC cis rs9399135 0.967 rs2150681 chr6:135375232 A/G cg24558204 chr6:135376177 HBS1L -0.6 -9.36 -0.46 1.22e-18 Red blood cell count; LUSC cis rs10876993 0.890 rs7963927 chr12:58046272 T/G cg18357645 chr12:58087776 OS9 0.5 7.51 0.38 5.45e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs62400317 0.762 rs857601 chr6:44805214 G/T cg20913747 chr6:44695427 NA 0.44 6.95 0.36 1.94e-11 Total body bone mineral density; LUSC cis rs1034435 0.755 rs5768679 chr22:48892847 T/G cg05992904 chr22:48892994 FAM19A5 -0.41 -8.16 -0.41 6.85e-15 Late-onset Alzheimer's disease; LUSC cis rs6547741 0.816 rs10201652 chr2:27874332 A/C cg12559939 chr2:27858050 GPN1 -0.39 -6.03 -0.31 4.25e-9 Oral cavity cancer; LUSC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg20790798 chr5:1857306 NA -0.45 -7.71 -0.39 1.43e-13 Cardiovascular disease risk factors; LUSC cis rs500891 0.525 rs13209274 chr6:84052966 C/T cg08257003 chr6:84140564 ME1 0.32 7.08 0.36 8.45e-12 Platelet-derived growth factor BB levels; LUSC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg25767906 chr1:53392781 SCP2 0.55 9.64 0.47 1.47e-19 Monocyte count; LUSC cis rs72781680 0.716 rs2675363 chr2:24080003 G/C cg08917208 chr2:24149416 ATAD2B 0.6 6.91 0.35 2.51e-11 Lymphocyte counts; LUSC cis rs6977660 1.000 rs6977660 chr7:19805480 C/T cg05791153 chr7:19748676 TWISTNB 0.55 6.24 0.32 1.31e-9 Thyroid stimulating hormone; LUSC cis rs2639990 0.744 rs640261 chr18:72905808 C/T cg11568697 chr18:72916393 ZADH2 0.61 6.63 0.34 1.39e-10 Vascular endothelial growth factor levels; LUSC cis rs11112613 0.648 rs11112635 chr12:106047112 A/G cg03607813 chr12:105948248 NA 0.42 5.77 0.3 1.78e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg16447950 chr5:562315 NA -0.6 -7.43 -0.38 9.17e-13 Obesity-related traits; LUSC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg27432699 chr2:27873401 GPN1 -0.56 -8.34 -0.42 1.94e-15 Total body bone mineral density; LUSC cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg04450456 chr4:17643702 FAM184B 0.37 6.25 0.32 1.26e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg09267113 chr7:98030324 BAIAP2L1 0.38 5.83 0.3 1.29e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg27494647 chr7:150038898 RARRES2 0.58 8.59 0.43 3.48e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs11577318 0.853 rs17645 chr1:26646730 A/G cg00852783 chr1:26633632 UBXN11 0.6 8.87 0.44 4.35e-17 Granulocyte percentage of myeloid white cells; LUSC cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.5 -7.59 -0.38 3.2e-13 Menarche (age at onset); LUSC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg10018233 chr7:150070692 REPIN1 0.39 6.76 0.35 6.1e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs10189230 0.967 rs12613015 chr2:222356119 G/A cg14652038 chr2:222343519 EPHA4 0.32 5.68 0.3 2.9e-8 Urate levels in lean individuals; LUSC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg20742385 chr13:113633654 MCF2L -0.31 -5.94 -0.31 7.21e-9 Systolic blood pressure; LUSC trans rs4911259 0.552 rs13042651 chr20:31467423 C/T cg09781936 chr22:19749961 TBX1 -0.34 -5.96 -0.31 6.46e-9 Inflammatory bowel disease; LUSC cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.812 rs17284472 chr3:41996304 A/G cg03022575 chr3:42003672 ULK4 -0.85 -8.81 -0.43 6.91e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs2303282 0.716 rs2617848 chr16:56399835 T/C cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg11645453 chr3:52864694 ITIH4 -0.36 -8.46 -0.42 8.66e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg17971929 chr21:40555470 PSMG1 0.57 7.12 0.36 6.84e-12 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13792025 chr7:66205470 RABGEF1 -0.4 -6.12 -0.32 2.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7560272 0.723 rs6744697 chr2:73765438 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -7.61 -0.38 2.86e-13 Schizophrenia; LUSC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg13683864 chr3:40499215 RPL14 -0.99 -16.92 -0.68 7.92e-47 Renal cell carcinoma; LUSC cis rs10489202 0.608 rs35059151 chr1:168079393 C/A cg24449463 chr1:168025552 DCAF6 -0.63 -9.51 -0.46 3.96e-19 Schizophrenia; LUSC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg18131467 chr2:239335373 ASB1 1.0 22.51 0.78 6.37e-69 Multiple system atrophy; LUSC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg21724239 chr8:58056113 NA 0.8 8.55 0.42 4.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs765787 0.505 rs4439707 chr15:45524216 G/A cg25801113 chr15:45476975 SHF -0.36 -7.18 -0.37 4.57e-12 Uric acid levels; LUSC trans rs804280 0.542 rs36100659 chr8:11791653 A/T cg15556689 chr8:8085844 FLJ10661 0.58 8.8 0.43 7.22e-17 Myopia (pathological); LUSC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg04287289 chr16:89883240 FANCA 0.76 6.26 0.32 1.19e-9 Skin colour saturation; LUSC cis rs2274273 0.710 rs67395212 chr14:55591939 T/A cg04306507 chr14:55594613 LGALS3 0.48 9.43 0.46 6.89e-19 Protein biomarker; LUSC cis rs4285028 0.898 rs73855476 chr3:121633412 A/G cg11130432 chr3:121712080 ILDR1 -0.64 -9.81 -0.47 3.84e-20 Multiple sclerosis; LUSC cis rs7215564 0.908 rs74000899 chr17:78653542 T/C cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.09e-11 Blood metabolite levels; LUSC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.38 -0.33 5.93e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9811920 0.931 rs7629487 chr3:99860401 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.35 6.55 0.34 2.18e-10 Axial length; LUSC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg05855489 chr10:104503620 C10orf26 -0.7 -10.18 -0.49 2.28e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9715521 0.677 rs11944208 chr4:59860652 G/A cg11281224 chr4:60001000 NA -0.51 -7.12 -0.36 6.72e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06022373 chr22:39101656 GTPBP1 -0.76 -12.0 -0.55 8.09e-28 Menopause (age at onset); LUSC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg20203395 chr5:56204925 C5orf35 -0.59 -8.41 -0.42 1.17e-15 Coronary artery disease; LUSC cis rs13064411 0.627 rs9872168 chr3:113233132 A/C cg18753928 chr3:113234510 CCDC52 -0.54 -8.2 -0.41 5.19e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs8028313 0.630 rs16951105 chr15:67965694 A/G cg24579218 chr15:68104479 NA -0.39 -6.52 -0.34 2.61e-10 Obesity; LUSC cis rs11098499 0.909 rs28884220 chr4:120307211 A/G cg24375607 chr4:120327624 NA 0.77 11.4 0.53 1.16e-25 Corneal astigmatism; LUSC cis rs4595586 0.545 rs1356265 chr12:39403696 A/G cg26384229 chr12:38710491 ALG10B 0.46 6.74 0.35 6.95e-11 Morning vs. evening chronotype; LUSC cis rs3812111 0.510 rs17077755 chr6:116592033 C/T cg18828861 chr6:116576566 TSPYL4 0.39 6.8 0.35 4.8e-11 Age-related macular degeneration; LUSC cis rs8072100 0.738 rs3736438 chr17:45486651 T/G cg08085267 chr17:45401833 C17orf57 -0.5 -7.25 -0.37 2.97e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs829883 0.867 rs1641640 chr12:98896017 A/G cg25150519 chr12:98850993 NA 0.63 9.43 0.46 7.25e-19 Colorectal adenoma (advanced); LUSC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg05425664 chr17:57184151 TRIM37 -0.58 -8.95 -0.44 2.51e-17 Intelligence (multi-trait analysis); LUSC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg04756594 chr16:24857601 SLC5A11 0.47 6.49 0.33 3.14e-10 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg13319975 chr6:146136371 FBXO30 -0.7 -10.81 -0.51 1.44e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg03233332 chr7:66118400 NA -0.4 -5.77 -0.3 1.83e-8 Aortic root size; LUSC cis rs2806561 0.765 rs2776815 chr1:23510584 C/T cg12483005 chr1:23474871 LUZP1 -0.44 -7.04 -0.36 1.09e-11 Height; LUSC cis rs9398803 0.763 rs576049 chr6:126730543 T/G cg19875578 chr6:126661172 C6orf173 0.43 6.27 0.32 1.11e-9 Male-pattern baldness; LUSC cis rs4812048 0.602 rs59637156 chr20:57619618 T/C cg14073986 chr20:57617431 SLMO2 0.88 9.56 0.46 2.65e-19 Mean platelet volume; LUSC cis rs950881 0.601 rs11465705 chr2:103058810 T/G cg20060108 chr2:102954350 IL1RL1 0.49 6.64 0.34 1.28e-10 Allergy; LUSC cis rs2974760 0.606 rs2858918 chr16:201183 T/C cg08400316 chr16:204221 HBZ 0.83 12.97 0.58 1.97e-31 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg08704250 chr15:31115839 NA 0.59 9.27 0.45 2.37e-18 Huntington's disease progression; LUSC cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg11266682 chr4:10021025 SLC2A9 0.57 10.5 0.5 1.84e-22 Bone mineral density; LUSC cis rs11122272 0.735 rs2066140 chr1:231504311 C/G cg06096015 chr1:231504339 EGLN1 0.56 10.06 0.48 5.82e-21 Hemoglobin concentration; LUSC cis rs713587 0.713 rs1982200 chr2:25205427 C/T cg15423357 chr2:25149977 NA -0.37 -7.35 -0.37 1.55e-12 Body mass index in non-asthmatics; LUSC cis rs796364 0.951 rs7586284 chr2:201068002 G/A cg23649088 chr2:200775458 C2orf69 0.49 6.77 0.35 5.85e-11 Schizophrenia; LUSC trans rs13011075 0.878 rs1542135 chr2:68620848 C/T cg14221825 chr19:46271408 SIX5 0.43 6.21 0.32 1.57e-9 Mean corpuscular volume; LUSC cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg04450456 chr4:17643702 FAM184B 0.36 5.89 0.31 9.29e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs57221529 0.713 rs56328416 chr5:591138 G/A cg11887960 chr12:57824829 NA 0.55 6.62 0.34 1.48e-10 Lung disease severity in cystic fibrosis; LUSC trans rs208520 1.000 rs72880045 chr6:66965232 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.34 0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs7264396 0.622 rs3787165 chr20:34228946 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.93 -0.48 1.58e-20 Total cholesterol levels; LUSC cis rs3796619 1.000 rs1453605 chr4:1075771 C/T cg27284194 chr4:1044797 NA 0.52 8.59 0.43 3.38e-16 Recombination rate (males); LUSC cis rs12545109 0.800 rs1837617 chr8:57417592 C/T cg09654669 chr8:57350985 NA -0.49 -6.5 -0.33 2.96e-10 Obesity-related traits; LUSC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg20135002 chr11:47629003 NA 0.49 7.8 0.39 8.06e-14 Subjective well-being; LUSC cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg17063962 chr7:91808500 NA 0.59 9.36 0.46 1.22e-18 Breast cancer; LUSC trans rs11098499 0.954 rs10518328 chr4:120401779 G/A cg25214090 chr10:38739885 LOC399744 0.54 8.05 0.4 1.44e-14 Corneal astigmatism; LUSC trans rs11165623 0.792 rs9437609 chr1:96977961 A/C cg10631902 chr5:14652156 NA -0.46 -7.26 -0.37 2.74e-12 Hip circumference;Waist circumference; LUSC cis rs4853525 0.859 rs6434424 chr2:191722126 A/C cg11845111 chr2:191398756 TMEM194B -0.4 -5.95 -0.31 6.95e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs2742417 0.967 rs2742426 chr3:45735901 A/G cg09608765 chr3:45636137 LIMD1 -0.36 -7.05 -0.36 1.04e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg24692254 chr21:30365293 RNF160 -0.85 -15.75 -0.65 3.56e-42 Dental caries; LUSC cis rs9840812 0.680 rs17252498 chr3:136014198 A/C cg15507776 chr3:136538369 TMEM22 -0.45 -5.69 -0.3 2.77e-8 Fibrinogen levels; LUSC cis rs9361491 0.657 rs7766318 chr6:79451515 A/C cg05283184 chr6:79620031 NA -0.32 -5.91 -0.31 8.65e-9 Intelligence (multi-trait analysis); LUSC cis rs1322512 0.677 rs1744392 chr6:152936093 G/T cg27316956 chr6:152958899 SYNE1 -0.35 -5.92 -0.31 7.84e-9 Tonometry; LUSC trans rs979233 0.502 rs276253 chr5:42062844 T/G cg07010552 chr17:7358735 CHRNB1 -0.42 -6.02 -0.31 4.47e-9 Systemic lupus erythematosus; LUSC cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg04455712 chr21:45112962 RRP1B 0.44 8.19 0.41 5.71e-15 Mean corpuscular volume; LUSC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg17376030 chr22:41985996 PMM1 0.51 6.35 0.33 7.03e-10 Vitiligo; LUSC cis rs1580019 0.961 rs4320456 chr7:32496003 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.81 0.54 3.97e-27 Cognitive ability; LUSC trans rs2492906 0.556 rs2815499 chr10:28087006 C/T cg06704170 chr2:85843078 USP39 -0.44 -6.04 -0.31 4.02e-9 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.4 7.94 0.4 3.05e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg13939156 chr17:80058883 NA -0.32 -6.38 -0.33 5.99e-10 Life satisfaction; LUSC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg01416388 chr22:39784598 NA -0.43 -7.17 -0.37 4.92e-12 Intelligence (multi-trait analysis); LUSC cis rs9790314 0.936 rs336572 chr3:161068014 G/A cg03342759 chr3:160939853 NMD3 -0.51 -8.38 -0.42 1.5e-15 Morning vs. evening chronotype; LUSC cis rs2180341 0.594 rs7738385 chr6:127777516 T/C cg24812749 chr6:127587940 RNF146 0.54 7.45 0.38 8.1e-13 Breast cancer; LUSC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg18252515 chr7:66147081 NA -1.21 -13.94 -0.61 4.07e-35 Diabetic kidney disease; LUSC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg04287289 chr16:89883240 FANCA 0.8 14.0 0.61 2.4e-35 Vitiligo; LUSC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.52 -0.38 5.1e-13 Intelligence (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg11238505 chr8:145691776 CYHR1;KIFC2 -0.39 -6.16 -0.32 2.15e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9303401 0.659 rs17222691 chr17:56771096 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.57 0.57 6.26e-30 Cognitive test performance; LUSC cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg23422044 chr7:1970798 MAD1L1 0.62 6.93 0.35 2.17e-11 Bipolar disorder; LUSC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg19346786 chr7:2764209 NA -0.48 -7.88 -0.4 4.61e-14 Height; LUSC cis rs1982963 0.627 rs8020559 chr14:52490690 T/G cg10843707 chr14:52510701 NID2 0.46 6.24 0.32 1.29e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2235642 0.685 rs2667681 chr16:1653206 C/T cg26528668 chr16:1614120 IFT140 0.44 7.19 0.37 4.24e-12 Coronary artery disease; LUSC cis rs6087990 0.669 rs2424929 chr20:31389518 A/G cg13636640 chr20:31349939 DNMT3B 0.92 18.94 0.72 7.43e-55 Ulcerative colitis; LUSC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg25566285 chr7:158114605 PTPRN2 -0.33 -6.23 -0.32 1.43e-9 Calcium levels; LUSC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg11764359 chr7:65958608 NA -0.78 -12.7 -0.57 2.07e-30 Aortic root size; LUSC cis rs77741769 0.571 rs3809313 chr12:121329967 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.71 0.43 1.42e-16 Mean corpuscular volume; LUSC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs4343996 0.837 rs7802250 chr7:3475820 G/C cg21248987 chr7:3385318 SDK1 0.36 5.91 0.31 8.33e-9 Motion sickness; LUSC cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg16339924 chr4:17578868 LAP3 0.56 8.4 0.42 1.32e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs734999 0.588 rs10910099 chr1:2533552 G/T cg18932078 chr1:2524107 MMEL1 -0.32 -7.2 -0.37 4.05e-12 Ulcerative colitis; LUSC trans rs7618501 0.633 rs7621026 chr3:49975334 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.26 0.45 2.61e-18 Intelligence (multi-trait analysis); LUSC cis rs9768139 0.634 rs11762383 chr7:158113889 C/T cg06219351 chr7:158114137 PTPRN2 -0.54 -9.82 -0.47 3.58e-20 Calcium levels; LUSC cis rs4820539 0.934 rs3788348 chr22:23467946 G/C cg14186256 chr22:23484241 RTDR1 0.96 18.11 0.7 1.53e-51 Bone mineral density; LUSC cis rs11645898 0.687 rs11075919 chr16:72106906 T/C cg14768367 chr16:72042858 DHODH -0.51 -5.99 -0.31 5.42e-9 Blood protein levels; LUSC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.44 -0.33 4.2e-10 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg16850897 chr7:100343110 ZAN -0.6 -8.39 -0.42 1.38e-15 Other erythrocyte phenotypes; LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg13560548 chr3:10150139 C3orf24 -0.48 -6.83 -0.35 4.03e-11 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10509185 chr10:134504666 INPP5A 0.52 7.03 0.36 1.19e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72960926 0.744 rs11756283 chr6:74901380 T/C cg03266952 chr6:74778945 NA -0.76 -6.05 -0.31 3.85e-9 Metabolite levels (MHPG); LUSC cis rs877282 0.786 rs11253392 chr10:788768 G/A cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC trans rs1005277 0.522 rs289643 chr10:37941494 T/G cg17830980 chr10:43048298 ZNF37B -0.43 -6.84 -0.35 3.77e-11 Extrinsic epigenetic age acceleration; LUSC cis rs9486719 0.947 rs12210834 chr6:96890407 A/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg08999081 chr20:33150536 PIGU -0.42 -7.88 -0.4 4.68e-14 Coronary artery disease; LUSC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12667521 chr19:29218732 NA 0.63 9.05 0.44 1.18e-17 Methadone dose in opioid dependence; LUSC cis rs2324229 0.828 rs1180202 chr6:83957723 A/C cg08257003 chr6:84140564 ME1 0.29 6.84 0.35 3.69e-11 Platelet-derived growth factor BB levels; LUSC cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg15839431 chr19:19639596 YJEFN3 -0.63 -7.15 -0.36 5.48e-12 Bipolar disorder; LUSC cis rs35883536 0.528 rs1542837 chr1:101029768 T/C cg09408571 chr1:101003634 GPR88 0.31 6.12 0.32 2.63e-9 Monocyte count; LUSC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Vitiligo; LUSC cis rs2963155 0.518 rs72801029 chr5:142625806 T/C cg17617527 chr5:142782415 NR3C1 0.8 8.79 0.43 8.12e-17 Breast cancer; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg16325326 chr1:53192061 ZYG11B 0.83 15.05 0.64 1.91e-39 Monocyte count; LUSC cis rs2050392 0.517 rs7096279 chr10:30759608 C/T cg18806716 chr10:30721971 MAP3K8 -0.61 -9.8 -0.47 4.27e-20 Inflammatory bowel disease; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg14004847 chr7:1930337 MAD1L1 -0.51 -7.76 -0.39 1.02e-13 Bipolar disorder and schizophrenia; LUSC cis rs7923609 0.811 rs12245367 chr10:65321464 C/T cg01631684 chr10:65280961 REEP3 0.4 5.84 0.3 1.22e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs629535 0.590 rs55988608 chr8:70133619 A/G cg21567404 chr3:27674614 NA -0.94 -13.6 -0.6 7.7e-34 Dupuytren's disease; LUSC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg24296786 chr1:45957014 TESK2 0.49 7.29 0.37 2.28e-12 High light scatter reticulocyte count; LUSC cis rs2262909 0.849 rs10420483 chr19:22190378 A/G cg11619707 chr19:22235551 ZNF257 -0.38 -5.65 -0.3 3.41e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs8072100 0.817 rs6505049 chr17:45675781 G/A cg03886242 chr7:26192032 NFE2L3 0.39 6.28 0.32 1.06e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1847202 0.859 rs13068268 chr3:72938132 G/A cg25664220 chr3:72788482 NA -0.39 -7.05 -0.36 1.06e-11 Motion sickness; LUSC cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg00484396 chr16:3507460 NAT15 -0.41 -6.78 -0.35 5.3e-11 Body mass index (adult); LUSC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg05147244 chr20:61493195 TCFL5 -0.69 -6.09 -0.32 3.09e-9 Obesity-related traits; LUSC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg14552801 chr7:65878734 NA 0.38 5.91 0.31 8.41e-9 Aortic root size; LUSC trans rs853679 0.599 rs188015 chr6:27877446 T/A cg01620082 chr3:125678407 NA -0.68 -7.04 -0.36 1.1e-11 Depression; LUSC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg18876405 chr7:65276391 NA -0.69 -12.38 -0.56 3.03e-29 Aortic root size; LUSC cis rs1483890 0.962 rs1483891 chr3:69410416 G/C cg22125112 chr3:69402811 FRMD4B 0.39 5.8 0.3 1.5e-8 Resting heart rate; LUSC cis rs2658782 1.000 rs2658779 chr11:93163137 G/T cg15737290 chr11:93063684 CCDC67 -0.65 -8.23 -0.41 4.17e-15 Pulmonary function decline; LUSC cis rs7605827 0.930 rs12995845 chr2:15520539 C/T cg19274914 chr2:15703543 NA 0.45 8.75 0.43 1.07e-16 Educational attainment (years of education); LUSC cis rs11971779 0.616 rs10278377 chr7:139103071 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg12463550 chr7:65579703 CRCP 0.52 7.63 0.39 2.55e-13 Aortic root size; LUSC cis rs7267979 1.000 rs1888999 chr20:25291848 C/T cg08601574 chr20:25228251 PYGB 0.41 6.4 0.33 5.31e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs3733585 0.673 rs6849729 chr4:9958732 T/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs35995292 0.500 rs6945239 chr7:38932208 C/T cg19327137 chr7:38886074 VPS41 0.55 10.26 0.49 1.15e-21 Subjective well-being (multi-trait analysis); LUSC cis rs6982240 0.569 rs6992286 chr8:142279412 G/A cg00131261 chr8:142287264 NA -0.39 -6.74 -0.35 7.11e-11 Tonsillectomy; LUSC cis rs425277 1.000 rs436045 chr1:2071556 A/G cg24578937 chr1:2090814 PRKCZ -0.6 -13.79 -0.6 1.44e-34 Height; LUSC cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg26384229 chr12:38710491 ALG10B 0.92 17.04 0.68 2.81e-47 Heart rate; LUSC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg02079420 chr8:82753780 SNX16 0.37 5.67 0.3 3.03e-8 Diastolic blood pressure; LUSC cis rs2742417 0.904 rs2251021 chr3:45796657 A/G cg09608765 chr3:45636137 LIMD1 0.32 6.06 0.31 3.69e-9 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs1994135 0.549 rs2218650 chr12:33734783 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.24 0.41 4.04e-15 Resting heart rate; LUSC cis rs7481584 0.924 rs4758502 chr11:2998461 C/T cg08508325 chr11:3079039 CARS 0.31 5.96 0.31 6.4e-9 Calcium levels; LUSC cis rs1957429 0.901 rs3813423 chr14:65347475 C/A cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg01256987 chr12:42539512 GXYLT1 -0.45 -8.45 -0.42 9.23e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7575217 0.588 rs7572457 chr2:101675808 A/G cg23907051 chr2:101730305 TBC1D8 0.26 6.61 0.34 1.53e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg18230493 chr5:56204884 C5orf35 -0.53 -8.5 -0.42 6.39e-16 Coronary artery disease; LUSC trans rs72674100 1.000 rs2865759 chr4:97992416 C/T cg00855990 chr1:18959354 PAX7 -0.6 -6.57 -0.34 1.94e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg25036284 chr2:26402008 FAM59B -0.68 -9.38 -0.46 1.06e-18 Gut microbiome composition (summer); LUSC cis rs1451375 0.669 rs59086818 chr7:50653830 G/A cg18232548 chr7:50535776 DDC 0.51 7.61 0.38 2.85e-13 Malaria; LUSC cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.35 0.33 7.03e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9300255 0.602 rs1716160 chr12:123700225 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg05802129 chr4:122689817 NA -0.52 -8.8 -0.43 7.4e-17 Type 2 diabetes; LUSC cis rs1506636 1.000 rs646753 chr7:123401237 G/T cg03229431 chr7:123269106 ASB15 0.65 10.7 0.51 3.66e-23 Plateletcrit;Platelet count; LUSC cis rs4664308 0.618 rs3749117 chr2:160885442 T/C cg03641300 chr2:160917029 PLA2R1 -0.47 -7.7 -0.39 1.51e-13 Idiopathic membranous nephropathy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08849938 chr19:57791810 ZNF460 -0.4 -6.04 -0.31 4.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg21724239 chr8:58056113 NA 0.54 6.6 0.34 1.63e-10 Developmental language disorder (linguistic errors); LUSC cis rs9814567 1.000 rs11919350 chr3:134235970 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.59 0.6 8.62e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2486288 0.656 rs12908818 chr15:45571668 A/G cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.9 -0.51 7.23e-24 Glomerular filtration rate; LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg14893161 chr1:205819251 PM20D1 0.59 10.03 0.48 7.08e-21 Menarche (age at onset); LUSC cis rs7923609 0.967 rs4454603 chr10:65012750 C/T cg01631684 chr10:65280961 REEP3 -0.42 -6.55 -0.34 2.14e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg12698349 chr2:225449008 CUL3 0.72 9.27 0.45 2.28e-18 IgE levels in asthmatics (D.p. specific); LUSC cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg24558204 chr6:135376177 HBS1L 0.68 10.47 0.5 2.3e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg18099408 chr3:52552593 STAB1 -0.4 -6.92 -0.35 2.26e-11 Bipolar disorder; LUSC cis rs9583531 0.657 rs9521915 chr13:111384528 C/T cg24331049 chr13:111365604 ING1 0.58 7.4 0.38 1.12e-12 Coronary artery disease; LUSC cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg22508957 chr16:3507546 NAT15 -0.4 -6.28 -0.32 1.06e-9 Body mass index (adult); LUSC cis rs765787 0.530 rs4775844 chr15:45542048 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.04e-16 Uric acid levels; LUSC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg19346786 chr7:2764209 NA -0.39 -6.9 -0.35 2.63e-11 Height; LUSC cis rs10465746 0.935 rs2389647 chr1:84403041 C/T cg10977910 chr1:84465055 TTLL7 0.41 5.94 0.31 7.32e-9 Obesity-related traits; LUSC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.23e-8 Aortic root size; LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg24675658 chr1:53192096 ZYG11B -0.7 -11.79 -0.54 4.57e-27 Monocyte count; LUSC cis rs2303282 0.700 rs35626903 chr16:56431613 A/G cg00500540 chr16:56394104 NA -0.39 -6.7 -0.34 8.91e-11 Breast cancer; LUSC cis rs4888262 0.526 rs4887777 chr16:74637821 A/G cg05580060 chr16:74700937 RFWD3 0.41 5.71 0.3 2.51e-8 Testicular germ cell tumor; LUSC cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg12310025 chr6:25882481 NA 0.6 10.04 0.48 6.62e-21 Blood metabolite levels; LUSC cis rs897080 0.552 rs1067377 chr2:44648239 T/G cg00619915 chr2:44497795 NA -0.42 -6.03 -0.31 4.46e-9 Height; LUSC cis rs360798 0.532 rs13013218 chr2:63011671 C/T cg17519650 chr2:63277830 OTX1 -0.51 -7.3 -0.37 2.15e-12 Coronary artery disease; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.7 0.3 2.64e-8 Menopause (age at onset); LUSC cis rs79911532 0.515 rs79131789 chr7:75756463 C/A cg03592824 chr7:75666768 STYXL1 0.67 6.37 0.33 6.32e-10 Mononucleosis; LUSC cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg22782873 chr19:19639568 YJEFN3 -0.53 -6.45 -0.33 3.94e-10 Bipolar disorder; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg19019804 chr17:72919384 OTOP2;USH1G -0.48 -6.3 -0.33 9.16e-10 Cognitive function;Information processing speed; LUSC trans rs8072100 0.875 rs7208530 chr17:45544107 C/T cg04995722 chr7:26192034 NFE2L3 -0.43 -6.59 -0.34 1.68e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs79839061 0.610 rs62297087 chr4:913289 T/A cg07828340 chr4:882639 GAK 0.95 10.1 0.48 4.07e-21 Intelligence (multi-trait analysis); LUSC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg11247378 chr22:39784982 NA 0.63 11.75 0.54 6.53e-27 Intelligence (multi-trait analysis); LUSC cis rs9790314 0.791 rs6809256 chr3:161026513 G/A cg03342759 chr3:160939853 NMD3 -0.56 -9.65 -0.47 1.39e-19 Morning vs. evening chronotype; LUSC cis rs113835537 0.529 rs57634456 chr11:66250838 A/C cg24851651 chr11:66362959 CCS 0.54 8.1 0.41 1.06e-14 Airway imaging phenotypes; LUSC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg03929089 chr4:120376271 NA -0.94 -16.2 -0.66 5.86e-44 Height; LUSC cis rs11971779 0.680 rs10265718 chr7:139100068 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg00509249 chr6:109615579 CCDC162 0.32 5.73 0.3 2.28e-8 Reticulocyte fraction of red cells; LUSC cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg24692254 chr21:30365293 RNF160 -0.93 -18.73 -0.72 5.09e-54 Dental caries; LUSC cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 9.05 0.44 1.21e-17 Mean platelet volume; LUSC cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg09877947 chr5:131593287 PDLIM4 0.44 7.3 0.37 2.12e-12 Blood metabolite levels; LUSC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg13683864 chr3:40499215 RPL14 1.07 21.28 0.76 4.17e-64 Renal cell carcinoma; LUSC cis rs6685188 0.925 rs12752037 chr1:205661614 A/C cg07167872 chr1:205819463 PM20D1 -0.46 -6.92 -0.35 2.37e-11 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs6088590 1.000 rs11698996 chr20:33449739 C/G cg08999081 chr20:33150536 PIGU 0.42 7.24 0.37 3.07e-12 Coronary artery disease; LUSC trans rs11935423 0.778 rs11933937 chr4:100489238 A/G cg02164153 chr5:172068145 NEURL1B -0.47 -6.01 -0.31 4.77e-9 Gut microbiome composition (summer); LUSC trans rs1814175 0.817 rs7483795 chr11:49704930 G/A cg03929089 chr4:120376271 NA -1.03 -19.85 -0.74 1.79e-58 Height; LUSC cis rs654950 0.806 rs1815257 chr1:42041479 A/C cg06885757 chr1:42089581 HIVEP3 -0.43 -8.67 -0.43 1.85e-16 Airway imaging phenotypes; LUSC cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg20503657 chr10:835505 NA -0.47 -6.49 -0.33 3.01e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg25566285 chr7:158114605 PTPRN2 -0.32 -6.1 -0.32 2.92e-9 Calcium levels; LUSC cis rs6500395 0.928 rs723807 chr16:48691443 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3925075 0.833 rs11641202 chr16:31330161 A/G cg02846316 chr16:31340340 ITGAM 0.33 5.95 0.31 6.84e-9 IgA nephropathy; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg26338869 chr17:61819248 STRADA 0.41 5.9 0.31 8.69e-9 Prudent dietary pattern; LUSC cis rs4820539 1.000 rs885965 chr22:23461425 A/G cg21100191 chr22:23484243 RTDR1 0.87 14.61 0.62 1.03e-37 Bone mineral density; LUSC cis rs4595586 0.545 rs2388177 chr12:39364403 T/C cg26384229 chr12:38710491 ALG10B 0.5 7.2 0.37 3.91e-12 Morning vs. evening chronotype; LUSC cis rs2637266 0.935 rs2579751 chr10:78339890 G/A cg18941641 chr10:78392320 NA 0.36 6.51 0.34 2.69e-10 Pulmonary function; LUSC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg06108461 chr20:60628389 TAF4 -0.97 -16.61 -0.67 1.39e-45 Body mass index; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg24503407 chr1:205819492 PM20D1 0.91 17.03 0.68 2.96e-47 Menarche (age at onset); LUSC cis rs7954584 0.567 rs11043233 chr12:122330733 C/T cg22618164 chr12:122356400 WDR66 0.62 9.43 0.46 6.98e-19 Mean corpuscular volume; LUSC cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.85 -0.35 3.57e-11 Monocyte percentage of white cells; LUSC cis rs2074585 0.839 rs11638780 chr15:91041896 G/T cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.69 -0.3 2.8e-8 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs4474465 0.920 rs4474466 chr11:78204406 C/T cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs713477 1.000 rs12893964 chr14:55912268 T/C cg13175173 chr14:55914753 NA -0.3 -6.35 -0.33 6.91e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -11.72 -0.54 8.03e-27 Systemic lupus erythematosus; LUSC cis rs17092148 1.000 rs11699062 chr20:33400379 A/T cg16810054 chr20:33298113 TP53INP2 0.45 6.77 0.35 5.85e-11 Neuroticism; LUSC trans rs1941687 0.524 rs6507062 chr18:31374197 G/C cg13755796 chr4:20253514 NA -0.42 -6.51 -0.34 2.77e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1865760 0.566 rs3752420 chr6:26027135 G/A cg17691542 chr6:26056736 HIST1H1C 0.51 7.63 0.39 2.51e-13 Height; LUSC cis rs4925386 0.808 rs1760073 chr20:60926106 A/G cg24112000 chr20:60950667 NA 0.36 6.82 0.35 4.3e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs12760731 0.720 rs16852717 chr1:178309723 T/C cg00404053 chr1:178313656 RASAL2 0.56 6.1 0.32 2.98e-9 Obesity-related traits; LUSC cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs738322 0.511 rs2267370 chr22:38576826 G/A cg25457927 chr22:38595422 NA -0.38 -7.23 -0.37 3.36e-12 Cutaneous nevi; LUSC cis rs1559088 0.847 rs6510348 chr19:33601946 G/A cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.03e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs96067 0.711 rs272811 chr1:36634414 G/A cg24686825 chr1:36642396 MAP7D1 -0.72 -11.26 -0.52 3.66e-25 Corneal structure; LUSC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg02269571 chr22:50332266 NA -0.59 -8.72 -0.43 1.31e-16 Schizophrenia; LUSC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg23625390 chr15:77176239 SCAPER 0.46 6.85 0.35 3.54e-11 Blood metabolite levels; LUSC cis rs1865760 0.663 rs9467656 chr6:25993559 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 6.82 0.35 4.36e-11 Height; LUSC cis rs7465272 1.000 rs7465272 chr8:143691838 A/T cg01509843 chr8:143695822 ARC 0.39 5.91 0.31 8.32e-9 Bipolar disorder and schizophrenia; LUSC cis rs7937682 0.564 rs9633937 chr11:111372799 C/T cg09085632 chr11:111637200 PPP2R1B 0.47 6.11 0.32 2.75e-9 Primary sclerosing cholangitis; LUSC cis rs9527 0.615 rs10883804 chr10:104706520 G/A cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.46 1.42e-18 Arsenic metabolism; LUSC cis rs9302635 0.513 rs35460163 chr16:72177060 C/T cg01557791 chr16:72042693 DHODH -0.51 -6.62 -0.34 1.47e-10 Blood protein levels; LUSC cis rs2976388 1.000 rs2976392 chr8:143762932 G/A cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs10791097 0.765 rs10894269 chr11:130722789 C/T cg12179176 chr11:130786555 SNX19 0.77 12.07 0.55 4.21e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg07701084 chr6:150067640 NUP43 0.57 8.82 0.43 6.57e-17 Lung cancer; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg00431813 chr7:1051703 C7orf50 -0.49 -8.17 -0.41 6.57e-15 Longevity;Endometriosis; LUSC cis rs1005224 0.926 rs12892551 chr14:76159902 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.64 -8.69 -0.43 1.66e-16 Large artery stroke; LUSC cis rs9814567 1.000 rs7356093 chr3:134238753 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.71 -0.6 2.98e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg10018233 chr7:150070692 REPIN1 0.4 7.22 0.37 3.51e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs1385374 0.858 rs12321643 chr12:129302867 A/T cg09035930 chr12:129282057 SLC15A4 -0.61 -6.56 -0.34 2.11e-10 Systemic lupus erythematosus; LUSC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg07701084 chr6:150067640 NUP43 0.57 8.87 0.44 4.47e-17 Lung cancer; LUSC cis rs7666738 0.546 rs13105521 chr4:98734419 C/T cg05340658 chr4:99064831 C4orf37 0.6 8.9 0.44 3.74e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04865715 chr14:92573100 ATXN3 0.45 6.16 0.32 2.04e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4595586 0.545 rs12833238 chr12:39373898 T/C cg26384229 chr12:38710491 ALG10B 0.49 6.99 0.36 1.51e-11 Morning vs. evening chronotype; LUSC cis rs9633740 0.545 rs2343306 chr10:82230146 A/G cg01528321 chr10:82214614 TSPAN14 -1.22 -16.16 -0.66 8.1e-44 Post bronchodilator FEV1; LUSC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs920590 0.684 rs57462676 chr8:19670848 G/C cg03894339 chr8:19674705 INTS10 0.58 7.79 0.39 8.28e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg22590775 chr19:49891494 CCDC155 -0.56 -7.36 -0.37 1.46e-12 Multiple sclerosis; LUSC cis rs8060686 0.641 rs12447640 chr16:68150527 A/G cg27539214 chr16:67997921 SLC12A4 -0.57 -7.4 -0.38 1.12e-12 HDL cholesterol;Metabolic syndrome; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04050850 chr2:219536800 STK36;RNF25 -0.49 -6.43 -0.33 4.49e-10 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.31e-41 Bladder cancer; LUSC cis rs1801251 1.000 rs283477 chr2:233649427 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.13 0.32 2.43e-9 Coronary artery disease; LUSC cis rs1577917 1.000 rs12204365 chr6:86700532 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.31e-11 Response to antipsychotic treatment; LUSC cis rs977987 0.806 rs8050059 chr16:75388731 C/T cg03315344 chr16:75512273 CHST6 0.51 9.54 0.46 3.04e-19 Dupuytren's disease; LUSC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg09796270 chr17:17721594 SREBF1 -0.42 -7.32 -0.37 1.85e-12 Total body bone mineral density; LUSC cis rs54211 1.000 rs54211 chr22:39687484 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.57 5.73 0.3 2.2e-8 Sudden cardiac arrest; LUSC cis rs3768617 0.811 rs10911200 chr1:182998377 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.78 0.43 8.63e-17 Fuchs's corneal dystrophy; LUSC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg09323728 chr8:95962352 TP53INP1 -0.39 -7.73 -0.39 1.24e-13 Type 2 diabetes; LUSC cis rs9831754 0.704 rs1512491 chr3:78470954 T/C cg06138941 chr3:78371609 NA 0.48 6.43 0.33 4.37e-10 Calcium levels; LUSC cis rs56161922 1.000 rs11118363 chr1:207859251 G/A cg11752769 chr1:207818423 CR1L 0.7 5.91 0.31 8.43e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs951366 0.576 rs12046305 chr1:205714478 G/A cg07157834 chr1:205819609 PM20D1 -0.44 -5.87 -0.31 1.03e-8 Menarche (age at onset); LUSC cis rs6696846 0.791 rs7520752 chr1:205054114 C/T cg21643547 chr1:205240462 TMCC2 0.4 7.35 0.37 1.57e-12 Red blood cell count; LUSC cis rs7833986 0.501 rs72653959 chr8:56996516 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.25 0.56 9.52e-29 Height; LUSC cis rs12893668 0.703 rs2274267 chr14:104029449 G/A cg08213375 chr14:104286397 PPP1R13B 0.35 5.9 0.31 8.79e-9 Reticulocyte count; LUSC cis rs4730250 0.554 rs17428504 chr7:106914944 T/C cg02696742 chr7:106810147 HBP1 -0.54 -7.09 -0.36 8.03e-12 Osteoarthritis; LUSC cis rs17401966 0.838 rs1538557 chr1:10297230 T/C cg19773385 chr1:10388646 KIF1B -0.52 -8.79 -0.43 7.75e-17 Hepatocellular carcinoma; LUSC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg02221750 chr19:17393354 ANKLE1 -0.91 -13.6 -0.6 8.08e-34 Systemic lupus erythematosus; LUSC trans rs9860340 0.730 rs4643731 chr3:87651251 T/C cg03644585 chr7:884825 UNC84A 0.43 6.07 0.32 3.52e-9 Electroencephalographic traits in alcoholism; LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.77 0.3 1.77e-8 Menopause (age at onset); LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.8 0.39 7.91e-14 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg17366294 chr4:99064904 C4orf37 0.61 10.74 0.51 2.7e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7072216 0.922 rs7097824 chr10:100151799 A/T cg26618903 chr10:100175079 PYROXD2 -0.29 -5.64 -0.3 3.57e-8 Metabolite levels; LUSC cis rs6840360 0.967 rs10776524 chr4:152602585 G/A cg22705602 chr4:152727874 NA -0.27 -5.71 -0.3 2.48e-8 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.07 0.52 1.76e-24 Alzheimer's disease; LUSC cis rs55675132 0.833 rs76537915 chr1:115636496 C/T cg01522456 chr1:115632236 TSPAN2 -0.45 -5.88 -0.31 1.02e-8 Schizophrenia; LUSC cis rs4654899 1.000 rs885363 chr1:21325360 C/A cg01072550 chr1:21505969 NA -0.55 -8.46 -0.42 8.55e-16 Superior frontal gyrus grey matter volume; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg16362232 chr11:430036 ANO9 -0.62 -8.13 -0.41 8.63e-15 Body mass index; LUSC cis rs12220238 1.000 rs11000925 chr10:75972601 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.22 0.37 3.42e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22307029 chr19:49891270 CCDC155 0.63 9.08 0.44 9.83e-18 Multiple sclerosis; LUSC cis rs950776 0.642 rs34694149 chr15:78965917 C/T cg06917634 chr15:78832804 PSMA4 0.49 6.81 0.35 4.58e-11 Sudden cardiac arrest; LUSC cis rs75920871 0.528 rs7124872 chr11:116927951 C/T cg01368799 chr11:117014884 PAFAH1B2 0.51 6.38 0.33 5.87e-10 Subjective well-being; LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg16393715 chr7:1948819 MAD1L1 0.35 6.06 0.31 3.59e-9 Bipolar disorder and schizophrenia; LUSC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg13319975 chr6:146136371 FBXO30 -0.53 -7.93 -0.4 3.44e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs926392 1.000 rs2867898 chr20:37690952 G/A cg27552599 chr20:37590471 DHX35 0.33 5.75 0.3 2.06e-8 Dialysis-related mortality; LUSC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.36 -5.96 -0.31 6.34e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs72781680 0.898 rs12619592 chr2:23971415 C/A cg08917208 chr2:24149416 ATAD2B 0.88 9.72 0.47 7.6e-20 Lymphocyte counts; LUSC cis rs36093844 0.848 rs1564550 chr11:85535361 A/T cg25872744 chr11:85566296 CCDC83 -0.44 -6.47 -0.33 3.4e-10 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs72674100 1.000 rs72874648 chr4:97964979 A/G cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg11812906 chr14:75593930 NEK9 0.65 10.58 0.5 9.14e-23 Height; LUSC cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.24 0.37 3.03e-12 Cognitive ability; LUSC cis rs72634258 0.786 rs7537362 chr1:8177564 C/T cg00042356 chr1:8021962 PARK7 0.58 7.12 0.36 6.71e-12 Inflammatory bowel disease; LUSC cis rs11048434 0.736 rs4309200 chr12:9121856 A/C cg23795048 chr12:9217529 LOC144571 0.34 5.87 0.31 1.08e-8 Sjögren's syndrome; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg23758822 chr17:41437982 NA 1.03 18.74 0.72 4.56e-54 Menopause (age at onset); LUSC cis rs55728055 0.661 rs55894054 chr22:31976299 T/C cg01338084 chr22:32026380 PISD 0.93 6.78 0.35 5.4e-11 Age-related hearing impairment; LUSC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs10746514 0.931 rs11582890 chr1:232251218 C/T cg09506761 chr1:232265262 NA 0.51 8.28 0.41 2.96e-15 Response to statin therapy; LUSC cis rs9527 0.590 rs34104646 chr10:104896078 T/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs13089785 0.965 rs12488058 chr3:123599681 C/T cg01860459 chr3:123419554 MYLK 0.34 5.66 0.3 3.27e-8 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg00750074 chr16:89608354 SPG7 -0.54 -9.83 -0.47 3.38e-20 Multiple myeloma (IgH translocation); LUSC cis rs939658 0.805 rs11635757 chr15:79432737 T/C cg17916960 chr15:79447300 NA -0.53 -10.55 -0.5 1.24e-22 Refractive error; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02374680 chr20:36322378 CTNNBL1 0.75 6.44 0.33 4.23e-10 Cognitive performance; LUSC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg08219700 chr8:58056026 NA 0.63 7.54 0.38 4.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs2258135 chr20:25272323 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.44 0.75 8.43e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs61931739 0.534 rs10844767 chr12:34152368 C/G cg06521331 chr12:34319734 NA -0.45 -7.39 -0.37 1.18e-12 Morning vs. evening chronotype; LUSC cis rs12545109 0.837 rs4738500 chr8:57356193 G/A cg09654669 chr8:57350985 NA -0.56 -7.48 -0.38 6.83e-13 Obesity-related traits; LUSC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg07936489 chr17:37558343 FBXL20 -0.44 -5.75 -0.3 1.98e-8 Glomerular filtration rate (creatinine); LUSC cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg16386425 chr10:429943 DIP2C -0.41 -6.53 -0.34 2.48e-10 Psychosis in Alzheimer's disease; LUSC cis rs8062405 0.755 rs12445823 chr16:28588049 A/C cg16576597 chr16:28551801 NUPR1 0.34 6.88 0.35 2.97e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs61990749 0.597 rs176944 chr14:78176211 G/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.44 -0.33 4.24e-10 Fibroblast growth factor basic levels; LUSC cis rs2742417 0.967 rs9825559 chr3:45740278 T/C cg09608765 chr3:45636137 LIMD1 -0.38 -7.58 -0.38 3.39e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg00149659 chr3:10157352 C3orf10 0.98 14.43 0.62 5.21e-37 Alzheimer's disease; LUSC cis rs372883 0.613 rs1153290 chr21:30687404 G/T cg08807101 chr21:30365312 RNF160 -0.66 -10.17 -0.49 2.33e-21 Pancreatic cancer; LUSC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg16339924 chr4:17578868 LAP3 0.6 9.43 0.46 7.3e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.23 0.37 3.3e-12 Platelet count; LUSC cis rs4919694 1.000 rs7099987 chr10:104807926 C/T cg04362960 chr10:104952993 NT5C2 1.17 13.83 0.6 1.04e-34 Arsenic metabolism; LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.57 -8.66 -0.43 2.07e-16 Alzheimer's disease (late onset); LUSC cis rs9325144 0.532 rs1352121 chr12:39130696 A/G cg26384229 chr12:38710491 ALG10B -0.59 -9.13 -0.45 6.6e-18 Morning vs. evening chronotype; LUSC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg04756594 chr16:24857601 SLC5A11 0.48 6.71 0.34 8.26e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs394563 0.601 rs431978 chr6:149793000 C/T cg07828024 chr6:149772892 ZC3H12D 0.35 6.9 0.35 2.68e-11 Dupuytren's disease; LUSC cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg09626299 chr10:82213104 TSPAN14 -0.2 -6.17 -0.32 2.03e-9 Post bronchodilator FEV1; LUSC cis rs4654899 0.772 rs10916892 chr1:21201325 A/G cg01072550 chr1:21505969 NA -0.5 -7.32 -0.37 1.88e-12 Superior frontal gyrus grey matter volume; LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg19318889 chr4:1322082 MAEA -0.55 -9.15 -0.45 5.8e-18 Obesity-related traits; LUSC cis rs2658782 0.724 rs2605627 chr11:93259515 A/G cg15737290 chr11:93063684 CCDC67 0.6 7.31 0.37 1.97e-12 Pulmonary function decline; LUSC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs73206853 0.764 rs73206878 chr12:110835015 A/C cg12870014 chr12:110450643 ANKRD13A 0.68 6.43 0.33 4.37e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1790761 0.692 rs10444362 chr11:67333090 G/A cg23188684 chr11:67383651 NA 0.34 6.01 0.31 4.94e-9 Mean corpuscular volume; LUSC cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7939886 0.920 rs59168428 chr11:55956018 G/A cg03929089 chr4:120376271 NA 0.82 6.22 0.32 1.53e-9 Myopia (pathological); LUSC trans rs12210905 0.920 rs858995 chr6:27181701 T/C cg01357846 chr2:79252794 REG3G -0.35 -5.97 -0.31 6.19e-9 Hip circumference adjusted for BMI; LUSC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.76 0.3 1.9e-8 Life satisfaction; LUSC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.68 0.34 9.88e-11 Systemic lupus erythematosus; LUSC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.13 0.41 8.43e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs11650494 1.000 rs11650494 chr17:47345186 G/A cg08112188 chr17:47440006 ZNF652 1.16 9.88 0.48 2.35e-20 Prostate cancer; LUSC cis rs7833787 1.000 rs7007413 chr8:18705432 A/G cg17701159 chr8:18705777 PSD3 0.38 6.38 0.33 5.95e-10 Obesity-related traits; LUSC trans rs61931739 0.534 rs2667447 chr12:34133468 C/A cg13010199 chr12:38710504 ALG10B 0.52 7.89 0.4 4.32e-14 Morning vs. evening chronotype; LUSC cis rs7605827 0.576 rs35785577 chr2:15659611 A/G cg19274914 chr2:15703543 NA 0.48 9.37 0.46 1.1e-18 Educational attainment (years of education); LUSC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg03030879 chr14:75389066 RPS6KL1 -0.39 -7.49 -0.38 6.2800000000000005e-13 Caffeine consumption; LUSC cis rs7829975 0.514 rs2976926 chr8:8261624 T/C cg15556689 chr8:8085844 FLJ10661 0.66 11.14 0.52 1.02e-24 Mood instability; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg07362569 chr17:61921086 SMARCD2 0.36 7.02 0.36 1.21e-11 Prudent dietary pattern; LUSC cis rs921968 0.565 rs608047 chr2:219615910 A/C cg02176678 chr2:219576539 TTLL4 0.56 9.99 0.48 1e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs4654899 0.865 rs6671056 chr1:21488610 G/A cg01072550 chr1:21505969 NA -0.49 -7.36 -0.37 1.47e-12 Superior frontal gyrus grey matter volume; LUSC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg16743903 chr16:89593216 SPG7 -0.37 -5.74 -0.3 2.15e-8 Multiple myeloma (IgH translocation); LUSC cis rs11677370 0.603 rs10174064 chr2:3849806 C/T cg17052675 chr2:3827356 NA -0.64 -10.2 -0.49 1.87e-21 Type 2 diabetes; LUSC trans rs9951602 0.512 rs73494176 chr18:76644895 T/C cg02800362 chr5:177631904 HNRNPAB 0.84 12.6 0.57 4.68e-30 Obesity-related traits; LUSC cis rs12594515 1.000 rs8043291 chr15:45996247 T/A cg01629716 chr15:45996671 NA 0.39 5.87 0.31 1.08e-8 Waist circumference;Weight; LUSC cis rs7954584 0.626 rs10840637 chr12:122427310 A/G cg21171335 chr12:122356390 WDR66 0.6 8.84 0.44 5.75e-17 Mean corpuscular volume; LUSC cis rs10754283 0.840 rs6428560 chr1:90102462 A/T cg21401794 chr1:90099060 LRRC8C 0.64 9.64 0.47 1.49e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg09323728 chr8:95962352 TP53INP1 -0.34 -6.2 -0.32 1.66e-9 Type 2 diabetes; LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg02951883 chr7:2050386 MAD1L1 -0.52 -9.35 -0.46 1.34e-18 Bipolar disorder and schizophrenia; LUSC cis rs367943 1.000 rs348930 chr5:112814763 T/C cg12552261 chr5:112820674 MCC -0.44 -7.06 -0.36 9.68e-12 Type 2 diabetes; LUSC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg13114125 chr14:105738426 BRF1 -0.95 -16.27 -0.66 3.09e-44 Mean platelet volume;Platelet distribution width; LUSC cis rs7582720 1.000 rs72936348 chr2:204064839 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.29 0.41 2.71e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9807989 0.811 rs7608638 chr2:102970289 A/G cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs9457247 0.756 rs1811123 chr6:167403443 T/C cg20406979 chr6:167373233 NA 0.25 5.76 0.3 1.92e-8 Crohn's disease; LUSC cis rs3741151 0.764 rs73548680 chr11:73271335 T/C cg17517138 chr11:73019481 ARHGEF17 0.98 8.16 0.41 6.87e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs11168351 0.927 rs7971880 chr12:48391055 C/T cg24011408 chr12:48396354 COL2A1 0.4 5.8 0.3 1.56e-8 Bipolar disorder and schizophrenia; LUSC cis rs10740039 0.883 rs10740037 chr10:62397505 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs394563 0.517 rs385303 chr6:149779064 C/T cg11245181 chr6:149772854 ZC3H12D -0.41 -8.13 -0.41 8.34e-15 Dupuytren's disease; LUSC cis rs4629180 0.586 rs7583526 chr2:102124665 G/A cg01388757 chr2:102091195 RFX8 -0.35 -6.08 -0.32 3.33e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7189233 0.531 rs56126229 chr16:53510687 G/A cg09728985 chr16:53543985 NA -0.31 -5.82 -0.3 1.38e-8 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg03354898 chr7:1950403 MAD1L1 -0.34 -6.52 -0.34 2.56e-10 Bipolar disorder and schizophrenia; LUSC cis rs11785400 1.000 rs11776301 chr8:143737142 A/G cg24634471 chr8:143751801 JRK 0.59 8.89 0.44 3.97e-17 Schizophrenia; LUSC trans rs9944715 0.954 rs13381529 chr18:43747827 A/T cg01718231 chr17:29326311 RNF135 0.51 7.19 0.37 4.3e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs861020 1.000 rs632746 chr1:209982515 C/T cg05527609 chr1:210001259 C1orf107 0.94 12.18 0.55 1.67e-28 Orofacial clefts; LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg09254001 chr12:99038219 IKBIP;APAF1 0.42 6.04 0.31 4.1e-9 Triglycerides; LUSC cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg23711669 chr6:146136114 FBXO30 -0.9 -17.65 -0.69 9.73e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs17266958 1.000 rs1332042 chr9:83312270 T/A cg01905489 chr1:26616534 UBXN11 -0.56 -6.09 -0.32 3.1e-9 Preschool internalizing problems; LUSC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg11344533 chr11:111475393 SIK2 -0.49 -6.89 -0.35 2.86e-11 Primary sclerosing cholangitis; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24532665 chr1:26146191 FAM54B 0.46 6.44 0.33 4.06e-10 Asthma; LUSC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg05585544 chr11:47624801 NA 0.41 7.19 0.37 4.39e-12 Subjective well-being; LUSC cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.58 0.57 5.44e-30 Motion sickness; LUSC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg12560992 chr17:57184187 TRIM37 0.82 15.12 0.64 1e-39 Intelligence (multi-trait analysis); LUSC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg07716408 chr11:68623521 NA -0.34 -6.8 -0.35 4.9e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7818345 1.000 rs11780343 chr8:19290963 C/T cg11303988 chr8:19266685 CSGALNACT1 0.36 7.03 0.36 1.2e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg16362232 chr11:430036 ANO9 0.71 8.65 0.43 2.24e-16 Body mass index; LUSC cis rs34779708 0.931 rs11010083 chr10:35351531 C/G cg04310649 chr10:35416472 CREM -0.42 -6.47 -0.33 3.56e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg05064044 chr6:292385 DUSP22 0.75 12.5 0.56 1.14e-29 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02362450 chr8:99129674 POP1;HRSP12 0.45 6.0 0.31 5.19e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.04 0.4 1.6e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg05585544 chr11:47624801 NA 0.41 7.21 0.37 3.88e-12 Subjective well-being; LUSC cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg05347473 chr6:146136440 FBXO30 0.45 7.69 0.39 1.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7561273 0.609 rs1056122 chr2:24342505 C/T cg20701182 chr2:24300061 SF3B14 -0.45 -5.82 -0.3 1.38e-8 Quantitative traits; LUSC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg22823121 chr1:150693482 HORMAD1 -0.46 -6.85 -0.35 3.47e-11 Tonsillectomy; LUSC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg11584989 chr19:19387371 SF4 0.51 6.78 0.35 5.58e-11 Bipolar disorder; LUSC cis rs9341808 0.754 rs3812126 chr6:80952701 A/G cg08355045 chr6:80787529 NA -0.55 -9.65 -0.47 1.33e-19 Sitting height ratio; LUSC cis rs9462027 0.606 rs7341253 chr6:34726838 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.91 -0.31 8.62e-9 Systemic lupus erythematosus; LUSC cis rs12681287 0.547 rs7465511 chr8:87521481 C/T cg00550725 chr8:87521180 FAM82B 0.44 5.73 0.3 2.2e-8 Caudate activity during reward; LUSC cis rs9660992 0.539 rs113699533 chr1:205122895 G/A cg21643547 chr1:205240462 TMCC2 -0.42 -7.67 -0.39 1.93e-13 Mean corpuscular volume;Mean platelet volume; LUSC trans rs6011368 0.840 rs2427638 chr20:62900717 C/T cg13869341 chr1:15865 WASH5P 0.43 6.87 0.35 3.17e-11 Clozapine-induced cytotoxicity; LUSC cis rs4713675 0.584 rs4713667 chr6:33680016 G/C cg14003231 chr6:33640908 ITPR3 0.3 5.77 0.3 1.84e-8 Plateletcrit; LUSC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg23711669 chr6:146136114 FBXO30 0.78 12.97 0.58 2.01e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg13628971 chr7:2884303 GNA12 0.46 6.79 0.35 5.03e-11 Height; LUSC cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.07 0.48 5.42e-21 Bladder cancer; LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T ch.3.541014R chr3:25654052 TOP2B -0.38 -6.0 -0.31 5.04e-9 Leprosy; LUSC cis rs8180040 0.522 rs749512 chr3:47035900 C/T cg16586182 chr3:47516702 SCAP 0.5 7.13 0.36 6.36e-12 Colorectal cancer; LUSC cis rs10779751 1.000 rs2076655 chr1:11289161 A/G cg08854313 chr1:11322531 MTOR -0.92 -15.7 -0.65 5.42e-42 Body mass index; LUSC cis rs9309473 0.528 rs11898362 chr2:73565293 G/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.96 -0.36 1.79e-11 Metabolite levels; LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.16 0.32 2.08e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9323205 0.677 rs12589680 chr14:51723138 T/C cg23942311 chr14:51606299 NA -0.39 -7.25 -0.37 2.92e-12 Cancer; LUSC cis rs477692 1.000 rs565974 chr10:131423274 C/T cg05714579 chr10:131428358 MGMT 0.5 7.43 0.38 9.36e-13 Response to temozolomide; LUSC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs593982 0.920 rs645621 chr11:65490756 T/C cg08755490 chr11:65554678 OVOL1 1.48 12.95 0.58 2.37e-31 Atopic dermatitis; LUSC cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg15556689 chr8:8085844 FLJ10661 0.69 10.92 0.51 6.09e-24 Neuroticism; LUSC cis rs9311676 0.632 rs11923181 chr3:58380569 A/C cg13750441 chr3:58318267 PXK 0.36 7.03 0.36 1.18e-11 Systemic lupus erythematosus; LUSC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg11663144 chr21:46675770 NA -0.35 -5.65 -0.3 3.44e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7618501 0.633 rs2526751 chr3:50064867 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -9.5 -0.46 4.34e-19 Intelligence (multi-trait analysis); LUSC cis rs9840812 0.610 rs34967300 chr3:136268818 A/G cg15507776 chr3:136538369 TMEM22 -0.45 -5.93 -0.31 7.39e-9 Fibrinogen levels; LUSC trans rs7178375 1.000 rs28693590 chr15:31195021 A/G cg04373760 chr16:53404718 NA 0.67 8.9 0.44 3.68e-17 Hypertriglyceridemia; LUSC cis rs6681460 1.000 rs6680944 chr1:67122565 A/T cg02459107 chr1:67143332 SGIP1 0.48 9.02 0.44 1.47e-17 Presence of antiphospholipid antibodies; LUSC cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg09184832 chr6:79620586 NA -0.42 -6.79 -0.35 5.28e-11 Intelligence (multi-trait analysis); LUSC cis rs887829 0.570 rs7563561 chr2:234598991 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -6.17 -0.32 1.92e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs56176327 0.583 rs7613603 chr3:49812866 C/T cg13072238 chr3:49761600 GMPPB 0.65 8.33 0.41 2.14e-15 Intelligence (multi-trait analysis); LUSC cis rs10498514 0.793 rs116373409 chr14:65039437 T/C cg25134081 chr14:64931936 AKAP5 0.95 6.53 0.34 2.45e-10 Cognitive performance; LUSC cis rs2559856 0.967 rs2695297 chr12:102082218 T/C cg12924262 chr12:102091054 CHPT1 0.42 5.84 0.3 1.24e-8 Blood protein levels; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg12432903 chr7:1882776 MAD1L1 -0.49 -8.13 -0.41 8.74e-15 Bipolar disorder and schizophrenia; LUSC cis rs11039100 0.681 rs11039170 chr11:5845187 T/G cg13902645 chr11:5959945 NA -0.54 -5.99 -0.31 5.41e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg10729496 chr3:10149963 C3orf24 0.53 6.38 0.33 5.92e-10 Alzheimer's disease; LUSC cis rs9329221 0.935 rs6601450 chr8:10243101 G/T cg21775007 chr8:11205619 TDH 0.5 7.21 0.37 3.75e-12 Neuroticism; LUSC cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg04518342 chr5:131593106 PDLIM4 0.46 8.56 0.42 4.27e-16 Breast cancer; LUSC cis rs796364 0.662 rs11688415 chr2:201143409 C/T cg23649088 chr2:200775458 C2orf69 0.56 6.49 0.33 3.17e-10 Schizophrenia; LUSC cis rs7824557 0.734 rs2293856 chr8:11177447 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.24 0.32 1.32e-9 Retinal vascular caliber; LUSC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg04733989 chr22:42467013 NAGA -0.41 -6.77 -0.35 5.96e-11 Cognitive function; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04875476 chr1:156720919 HDGF -0.43 -6.21 -0.32 1.59e-9 Electrocardiographic conduction measures; LUSC cis rs73206853 0.841 rs73206854 chr12:110731375 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.53 0.38 4.86e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg20283391 chr11:68216788 NA -0.54 -8.04 -0.4 1.58e-14 Total body bone mineral density; LUSC cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.67 0.39 1.9e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2302729 0.860 rs7138079 chr12:2781304 G/A cg19945202 chr12:2788847 CACNA1C -0.39 -5.87 -0.31 1.07e-8 Sleep quality; LUSC cis rs877282 0.853 rs4579862 chr10:753298 A/C cg17470449 chr10:769945 NA 0.49 6.69 0.34 9.39e-11 Uric acid levels; LUSC cis rs72781680 0.898 rs72788302 chr2:24107246 C/T cg20701182 chr2:24300061 SF3B14 0.73 7.33 0.37 1.76e-12 Lymphocyte counts; LUSC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg11764359 chr7:65958608 NA -0.78 -12.69 -0.57 2.23e-30 Aortic root size; LUSC cis rs61931739 0.534 rs11052991 chr12:34059018 G/T cg06521331 chr12:34319734 NA 0.48 7.94 0.4 3.09e-14 Morning vs. evening chronotype; LUSC cis rs2200578 0.626 rs72959128 chr2:99769602 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.44 0.33 4.24e-10 IgG glycosylation; LUSC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg24011408 chr12:48396354 COL2A1 -0.44 -6.53 -0.34 2.47e-10 Glycated hemoglobin levels; LUSC cis rs1775715 0.870 rs1755080 chr10:32255195 G/A cg26784012 chr10:32216390 ARHGAP12 0.4 6.45 0.33 3.85e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs3806843 0.966 rs1030163 chr5:140185132 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1348850 0.668 rs13034886 chr2:178493301 G/T cg22681709 chr2:178499509 PDE11A -0.46 -7.44 -0.38 8.46e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg03146154 chr1:46216737 IPP 0.55 8.33 0.41 2.13e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4851254 0.660 rs34714421 chr2:100692175 T/C cg07810366 chr2:100720526 AFF3 -0.45 -6.06 -0.31 3.7e-9 Intelligence (multi-trait analysis); LUSC cis rs9469578 1.000 rs16869466 chr6:33715265 A/G cg18708504 chr6:33715942 IP6K3 0.72 8.8 0.43 7.52e-17 Phosphorus levels; LUSC cis rs6062509 0.965 rs4809330 chr20:62349586 A/G cg21849932 chr20:62369462 LIME1 -0.4 -5.92 -0.31 8e-9 Prostate cancer; LUSC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg02018176 chr4:1364513 KIAA1530 0.49 8.27 0.41 3.33e-15 Obesity-related traits; LUSC trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs35272691 1 rs35272691 chr17:38157841 T/C cg17467752 chr17:38218738 THRA -0.51 -7.15 -0.36 5.59e-12 White blood cell count (neutrophil); LUSC cis rs7851660 0.809 rs12006522 chr9:100652711 G/C cg13688889 chr9:100608707 NA -0.53 -8.06 -0.4 1.36e-14 Strep throat; LUSC cis rs2439831 0.702 rs9989313 chr15:44152817 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.89 8.77 0.43 9.6e-17 Lung cancer in ever smokers; LUSC cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.57 7.21 0.37 3.83e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 7.98 0.4 2.34e-14 Axial length; LUSC cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg10523679 chr1:76189770 ACADM -0.51 -7.56 -0.38 3.9e-13 Daytime sleep phenotypes; LUSC trans rs1994135 0.692 rs1579909 chr12:33694780 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.41 0.42 1.2e-15 Resting heart rate; LUSC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg19257562 chr1:2043853 PRKCZ 0.29 5.77 0.3 1.85e-8 Height; LUSC cis rs6964587 0.597 rs975707 chr7:91874527 C/G cg17063962 chr7:91808500 NA 0.56 9.05 0.44 1.24e-17 Breast cancer; LUSC cis rs2050392 0.767 rs10763786 chr10:30693567 G/C cg18806716 chr10:30721971 MAP3K8 0.7 11.23 0.52 5.01e-25 Inflammatory bowel disease; LUSC cis rs9472414 0.680 rs9463040 chr6:44752286 C/T cg20913747 chr6:44695427 NA 0.41 6.03 0.31 4.28e-9 Height; LUSC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg18876405 chr7:65276391 NA -0.66 -11.66 -0.54 1.34e-26 Aortic root size; LUSC cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg03146154 chr1:46216737 IPP -0.51 -7.43 -0.38 9.2e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs36093844 0.752 rs56396016 chr11:85596390 C/A cg25872744 chr11:85566296 CCDC83 -0.45 -5.86 -0.31 1.14e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.66e-8 Morning vs. evening chronotype; LUSC cis rs9687065 1.000 rs7704297 chr5:148390295 A/G cg23229984 chr5:148520753 ABLIM3 -0.39 -6.15 -0.32 2.26e-9 Diastolic blood pressure; LUSC trans rs2834485 1.000 rs2834484 chr21:35816941 G/T cg07474852 chr4:123073612 NA -0.44 -6.5 -0.34 2.89e-10 Cancer; LUSC trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg03929089 chr4:120376271 NA -0.6 -7.24 -0.37 3.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs9768139 0.903 rs10262701 chr7:158114591 G/A cg24154853 chr7:158122151 PTPRN2 -0.42 -8.18 -0.41 6.1e-15 Calcium levels; LUSC cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg05347473 chr6:146136440 FBXO30 0.55 9.47 0.46 5.41e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs1595825 0.786 rs116046984 chr2:198884413 G/A cg00982548 chr2:198649783 BOLL -0.54 -6.88 -0.35 2.9e-11 Ulcerative colitis; LUSC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg01657329 chr11:68192670 LRP5 -0.45 -7.1 -0.36 7.74e-12 Total body bone mineral density; LUSC cis rs12824058 0.844 rs10744458 chr12:130805820 C/T cg27633287 chr12:130766243 NA -0.33 -6.25 -0.32 1.27e-9 Menopause (age at onset); LUSC cis rs7824557 0.603 rs7016671 chr8:11182455 A/G cg21775007 chr8:11205619 TDH 0.77 12.86 0.58 5.27e-31 Retinal vascular caliber; LUSC trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg03929089 chr4:120376271 NA -0.76 -10.3 -0.49 8.69e-22 Coronary artery disease; LUSC cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg21535247 chr6:8435926 SLC35B3 -0.58 -8.97 -0.44 2.17e-17 Motion sickness; LUSC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.87 0.35 3.2e-11 Intelligence (multi-trait analysis); LUSC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 0.39 6.0 0.31 5.15e-9 Total body bone mineral density; LUSC cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.89 -0.31 9.18e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg04450456 chr4:17643702 FAM184B 0.38 6.37 0.33 6.19e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg14552801 chr7:65878734 NA 0.38 5.9 0.31 8.97e-9 Aortic root size; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg06877462 chr1:205807181 PM20D1 0.38 7.05 0.36 1.03e-11 Menarche (age at onset); LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg04267008 chr7:1944627 MAD1L1 -0.54 -8.0 -0.4 2e-14 Bipolar disorder and schizophrenia; LUSC cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.22 0.45 3.52e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.71 -0.34 8.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.583 rs4448232 chr8:11231354 G/T cg27411982 chr8:10470053 RP1L1 0.37 5.71 0.3 2.54e-8 Retinal vascular caliber; LUSC cis rs5167 0.566 rs7253458 chr19:45482570 C/T cg13119609 chr19:45449297 APOC2 0.34 5.67 0.3 3.01e-8 Blood protein levels; LUSC cis rs7177699 0.550 rs7182716 chr15:79123753 T/C cg15571903 chr15:79123663 NA 0.34 6.32 0.33 8.21e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg23711669 chr6:146136114 FBXO30 0.93 18.43 0.71 7.84e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg16520312 chr17:43971471 MAPT;LOC100128977 0.36 6.2 0.32 1.69e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg01973587 chr1:228161476 NA 0.42 7.77 0.39 9.84e-14 Diastolic blood pressure; LUSC trans rs2204008 0.683 rs7305703 chr12:38138381 T/C cg06521331 chr12:34319734 NA -0.4 -6.29 -0.33 1.01e-9 Bladder cancer; LUSC cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs28830936 1.000 rs112896623 chr15:42001845 C/T cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.0 -0.31 5.06e-9 Diastolic blood pressure; LUSC trans rs6852435 1.000 rs62335849 chr4:175304179 A/G cg23753247 chr11:8615842 STK33 -0.53 -5.97 -0.31 5.91e-9 Response to acetaminophen (hepatotoxicity); LUSC cis rs10986311 0.862 rs2416924 chr9:127108146 A/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.38 5.87 0.31 1.06e-8 Vitiligo; LUSC trans rs800082 0.501 rs10935507 chr3:144214631 A/T cg24215973 chr2:240111563 HDAC4 0.49 7.36 0.37 1.48e-12 Smoking behavior; LUSC cis rs1538970 0.924 rs1006216 chr1:45909994 A/G cg05343316 chr1:45956843 TESK2 0.66 9.01 0.44 1.62e-17 Platelet count; LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg13114125 chr14:105738426 BRF1 -0.95 -16.27 -0.66 3.09e-44 Mean platelet volume;Platelet distribution width; LUSC cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg24642439 chr20:33292090 TP53INP2 0.43 6.16 0.32 2.07e-9 Height; LUSC cis rs11031096 0.727 rs7932702 chr11:4124372 C/T cg18678763 chr11:4115507 RRM1 -0.48 -6.91 -0.35 2.39e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.54 0.42 4.93e-16 Prudent dietary pattern; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18099408 chr3:52552593 STAB1 -0.39 -6.95 -0.36 1.9e-11 Electroencephalogram traits; LUSC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg11062466 chr8:58055876 NA 0.42 5.66 0.3 3.32e-8 Developmental language disorder (linguistic errors); LUSC cis rs9549260 1.000 rs9549260 chr13:41254104 G/T cg21288729 chr13:41239152 FOXO1 0.46 6.09 0.32 3.07e-9 Red blood cell count; LUSC cis rs6500395 0.962 rs9972682 chr16:48686644 T/G cg04672837 chr16:48644449 N4BP1 0.44 6.29 0.33 1.01e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg13560548 chr3:10150139 C3orf24 0.51 7.32 0.37 1.92e-12 Alzheimer's disease; LUSC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11644478 chr21:40555479 PSMG1 -0.77 -13.55 -0.6 1.24e-33 Cognitive function; LUSC trans rs2319125 0.866 rs229859 chr17:64121580 A/T cg06156093 chr1:184633273 NA 0.37 6.27 0.32 1.13e-9 &beta2-Glycoprotein I (β2-GPI) plasma levels; LUSC cis rs1348850 0.793 rs6736390 chr2:178480314 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.17 0.32 1.97e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7615316 0.934 rs13098343 chr3:142228486 T/C cg16271453 chr3:142027066 XRN1 -0.4 -6.87 -0.35 3.22e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs11923600 0.793 rs62285822 chr3:175890900 T/C cg02188190 chr13:112894616 NA 0.44 6.21 0.32 1.58e-9 Height; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.36 -0.37 1.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg26441486 chr22:50317300 CRELD2 0.52 7.95 0.4 2.85e-14 Schizophrenia; LUSC cis rs34891900 0.507 rs2587084 chr22:18140644 T/G cg08824373 chr22:18117835 NA -0.41 -6.35 -0.33 7.07e-10 Sum neutrophil eosinophil counts; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg21782813 chr7:2030301 MAD1L1 0.49 8.37 0.42 1.59e-15 Bipolar disorder and schizophrenia; LUSC cis rs983392 0.667 rs631853 chr11:59944898 T/G cg02771260 chr11:59836817 MS4A3 0.36 6.21 0.32 1.54e-9 Alzheimer's disease (late onset); LUSC trans rs1973993 0.672 rs17367240 chr1:96960057 G/A cg10631902 chr5:14652156 NA -0.46 -6.8 -0.35 4.72e-11 Weight; LUSC cis rs2439831 0.681 rs526450 chr15:43599325 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.85 10.52 0.5 1.49e-22 Lung cancer in ever smokers; LUSC cis rs9650315 0.866 rs13254111 chr8:57181776 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.34 0.33 7.34e-10 Height; LUSC cis rs2074585 0.806 rs2657949 chr15:90950790 G/A cg04176472 chr15:90893244 GABARAPL3 0.35 5.99 0.31 5.41e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9287719 0.967 rs715246 chr2:10736355 G/A cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg04369109 chr6:150039330 LATS1 -0.56 -8.4 -0.42 1.3e-15 Lung cancer; LUSC cis rs3126085 0.935 rs877776 chr1:152178018 C/G cg26876637 chr1:152193138 HRNR 0.38 5.66 0.3 3.22e-8 Atopic dermatitis; LUSC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg05234568 chr11:5960015 NA -0.55 -7.95 -0.4 2.92e-14 DNA methylation (variation); LUSC cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg24642439 chr20:33292090 TP53INP2 0.51 7.65 0.39 2.14e-13 Height; LUSC cis rs8180040 0.966 rs3816779 chr3:47543389 C/T cg16586182 chr3:47516702 SCAP -0.48 -7.58 -0.38 3.45e-13 Colorectal cancer; LUSC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg18131467 chr2:239335373 ASB1 0.96 21.24 0.76 5.97e-64 Multiple system atrophy; LUSC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg22834771 chr12:69754056 YEATS4 -0.49 -7.37 -0.37 1.31e-12 Blood protein levels; LUSC cis rs2439831 1.000 rs2467736 chr15:43784917 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs2361710 0.668 rs4889830 chr17:78114528 G/A cg06718696 chr17:78121285 EIF4A3 0.43 6.24 0.32 1.33e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC trans rs853679 0.546 rs34371502 chr6:28081758 T/C cg06606381 chr12:133084897 FBRSL1 -1.05 -9.08 -0.44 9.63e-18 Depression; LUSC cis rs77106637 0.860 rs75896506 chr11:72429579 G/A cg03713592 chr11:72463424 ARAP1 1.03 11.06 0.52 1.92e-24 Type 2 diabetes; LUSC cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg04450456 chr4:17643702 FAM184B 0.39 6.54 0.34 2.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.75 0.35 6.73e-11 Cystic fibrosis severity; LUSC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.54 0.46 3.19e-19 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.517 rs1486882 chr12:34025896 A/G cg13010199 chr12:38710504 ALG10B 0.55 8.37 0.42 1.63e-15 Morning vs. evening chronotype; LUSC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg04398451 chr17:18023971 MYO15A -0.48 -7.65 -0.39 2.12e-13 Total body bone mineral density; LUSC cis rs60695258 0.529 rs340630 chr4:87958395 G/A cg10685359 chr4:87814065 C4orf36 0.34 6.06 0.31 3.59e-9 Hematocrit; LUSC cis rs1949733 0.816 rs2631746 chr4:8490934 C/T cg11789530 chr4:8429930 ACOX3 -0.54 -8.52 -0.42 5.39e-16 Response to antineoplastic agents; LUSC cis rs55986470 0.763 rs11888775 chr2:239424876 C/T cg18131467 chr2:239335373 ASB1 0.52 5.99 0.31 5.31e-9 Chronotype; LUSC cis rs6977660 0.714 rs7357319 chr7:19817525 A/G cg05791153 chr7:19748676 TWISTNB 0.67 7.1 0.36 7.78e-12 Thyroid stimulating hormone; LUSC cis rs1953600 1.000 rs2789679 chr10:81907884 A/T cg00277334 chr10:82204260 NA -0.51 -7.86 -0.4 5.27e-14 Sarcoidosis; LUSC cis rs1858037 0.867 rs67453645 chr2:65586042 C/T cg08085232 chr2:65598271 SPRED2 -0.4 -5.95 -0.31 6.88e-9 Rheumatoid arthritis; LUSC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.63 9.54 0.46 3.12e-19 Height; LUSC cis rs3106136 0.900 rs13142645 chr4:95208714 A/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.09 -0.32 3.14e-9 Capecitabine sensitivity; LUSC cis rs34779708 0.966 rs4934735 chr10:35496730 C/T cg04310649 chr10:35416472 CREM 0.4 6.25 0.32 1.26e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg06873352 chr17:61820015 STRADA 0.72 12.98 0.58 1.79e-31 Prudent dietary pattern; LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg23093090 chr10:104574429 C10orf26 -0.43 -7.47 -0.38 7.05e-13 Arsenic metabolism; LUSC cis rs3820928 0.874 rs10177995 chr2:227781600 T/C cg11843606 chr2:227700838 RHBDD1 -0.55 -8.01 -0.4 1.99e-14 Pulmonary function; LUSC cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg21535247 chr6:8435926 SLC35B3 0.58 9.13 0.45 6.72e-18 Motion sickness; LUSC trans rs57221529 0.713 rs56328416 chr5:591138 G/A cg25482853 chr8:67687455 SGK3 1.18 16.55 0.67 2.28e-45 Lung disease severity in cystic fibrosis; LUSC cis rs2667011 0.512 rs77743444 chr2:160804410 G/C cg06573604 chr2:160760825 LY75 0.45 6.28 0.32 1.07e-9 Bilirubin levels; LUSC cis rs7216064 0.953 rs11868959 chr17:65840810 T/C cg12091567 chr17:66097778 LOC651250 -0.75 -9.35 -0.46 1.27e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs61931739 0.649 rs815049 chr12:33726757 G/C cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg00049323 chr5:472564 LOC25845 -0.43 -6.48 -0.33 3.34e-10 Cystic fibrosis severity; LUSC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg13319975 chr6:146136371 FBXO30 0.51 7.75 0.39 1.15e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs79976124 0.842 rs74881738 chr6:66621825 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 8.13 0.41 8.64e-15 Type 2 diabetes; LUSC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.08 -0.32 3.37e-9 Developmental language disorder (linguistic errors); LUSC cis rs11158026 0.501 rs67620272 chr14:55351579 G/C cg04306507 chr14:55594613 LGALS3 0.4 6.41 0.33 4.88e-10 Parkinson's disease; LUSC trans rs8072100 0.870 rs10432035 chr17:45624913 G/C cg04995722 chr7:26192034 NFE2L3 0.37 6.12 0.32 2.6e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1577917 1.000 rs12203924 chr6:86776412 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.46 -0.42 8.72e-16 Response to antipsychotic treatment; LUSC cis rs1577917 0.958 rs12193904 chr6:86452703 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.07 -0.36 9.36e-12 Response to antipsychotic treatment; LUSC cis rs7172677 0.501 rs8040061 chr15:75393720 C/A cg14664628 chr15:75095509 CSK 0.43 6.07 0.32 3.43e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9788682 0.747 rs28480606 chr15:78762313 A/G cg18825076 chr15:78729989 IREB2 0.44 6.13 0.32 2.46e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9640161 0.711 rs3735170 chr7:150034184 T/C cg27494647 chr7:150038898 RARRES2 0.57 8.51 0.42 5.88e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs7089973 0.604 rs58587374 chr10:116597572 A/G cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.23e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7267979 0.873 rs7453 chr20:25207074 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.78 16.24 0.66 3.92e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3784262 0.528 rs1994926 chr15:58334587 C/T cg12031962 chr15:58353849 ALDH1A2 -0.3 -5.77 -0.3 1.78e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs2762353 0.935 rs1165213 chr6:25799676 A/G cg12310025 chr6:25882481 NA 0.39 6.86 0.35 3.43e-11 Blood metabolite levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23145915 chr12:58146234 CDK4 -0.46 -6.01 -0.31 4.8e-9 Bipolar disorder and schizophrenia; LUSC cis rs72792276 1.000 rs72794386 chr5:127479278 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.91 8.4 0.42 1.31e-15 Red cell distribution width; LUSC cis rs10823500 0.604 rs10740329 chr10:71941253 A/T cg26699283 chr10:71892715 AIFM2 0.38 6.04 0.31 4.17e-9 Blood protein levels; LUSC cis rs929354 0.742 rs3808316 chr7:156944787 C/G cg17757837 chr7:157058334 UBE3C 0.83 13.17 0.58 3.51e-32 Body mass index; LUSC cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.49 0.38 6.07e-13 Motion sickness; LUSC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg03526776 chr6:41159608 TREML2 -0.32 -6.23 -0.32 1.4e-9 Alzheimer's disease (late onset); LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg10360139 chr7:1886902 MAD1L1 -0.44 -6.69 -0.34 9.17e-11 Bipolar disorder and schizophrenia; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg13012494 chr21:47604986 C21orf56 -0.51 -7.81 -0.39 7.43e-14 Testicular germ cell tumor; LUSC cis rs11055008 0.620 rs10845608 chr12:12836088 C/T cg09462578 chr12:12878428 APOLD1 0.43 6.31 0.33 8.73e-10 Pulse pressure; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs7937682 0.921 rs11213940 chr11:111433927 C/A cg19812747 chr11:111475976 SIK2 0.52 7.18 0.37 4.63e-12 Primary sclerosing cholangitis; LUSC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.14 0.36 5.83e-12 Major depressive disorder; LUSC cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg00631329 chr6:26305371 NA -0.45 -8.84 -0.44 5.59e-17 Educational attainment; LUSC cis rs1419980 1.000 rs1419980 chr12:7774892 A/G cg10578777 chr12:7781093 NA -0.7 -6.77 -0.35 5.76e-11 HDL cholesterol levels; LUSC cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg22852734 chr6:133119734 C6orf192 0.98 8.74 0.43 1.19e-16 Type 2 diabetes nephropathy; LUSC cis rs1728785 0.591 rs10775305 chr16:68656460 A/G cg02972257 chr16:68554789 NA -0.5 -6.27 -0.32 1.12e-9 Ulcerative colitis; LUSC cis rs727505 0.954 rs1014163 chr7:124443604 G/A cg23710748 chr7:124431027 NA -0.43 -7.83 -0.39 6.49e-14 Lewy body disease; LUSC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg09365446 chr1:150670422 GOLPH3L 0.51 7.93 0.4 3.36e-14 Tonsillectomy; LUSC cis rs500891 0.574 rs7757427 chr6:84131300 T/A cg08257003 chr6:84140564 ME1 0.37 9.02 0.44 1.53e-17 Platelet-derived growth factor BB levels; LUSC cis rs208520 0.526 rs7775830 chr6:66755249 A/G cg07460842 chr6:66804631 NA 1.22 25.21 0.81 2.81e-79 Exhaled nitric oxide output; LUSC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg08439880 chr3:133502540 NA -0.38 -6.81 -0.35 4.66e-11 Iron status biomarkers; LUSC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs6424115 0.708 rs12755062 chr1:24185025 T/A cg10978503 chr1:24200527 CNR2 -0.46 -9.5 -0.46 4.32e-19 Immature fraction of reticulocytes; LUSC cis rs17021463 0.966 rs7657789 chr4:95178589 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.52 -0.42 5.42e-16 Testicular germ cell tumor; LUSC trans rs931812 0.895 rs4734013 chr8:101908687 A/C cg20993868 chr7:22813445 NA 0.65 11.78 0.54 5.1e-27 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs9811920 0.535 rs793483 chr3:99489825 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.3 -5.76 -0.3 1.87e-8 Axial length; LUSC cis rs929596 0.639 rs2070959 chr2:234602191 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -7.76 -0.39 1.06e-13 Total bilirubin levels in HIV-1 infection; LUSC cis rs950169 0.840 rs4842854 chr15:84942339 T/G cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs1499972 0.941 rs62264783 chr3:117658033 G/A cg07612923 chr3:117604196 NA 0.63 5.72 0.3 2.32e-8 Schizophrenia; LUSC cis rs472402 0.560 rs10037161 chr5:6624294 C/A cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.53 -7.7 -0.39 1.55e-13 Response to amphetamines; LUSC cis rs6582630 0.599 rs4882313 chr12:38454011 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.67 -0.34 1.04e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs7100689 0.646 rs1572819 chr10:82112488 A/G cg07663200 chr17:42030104 NA -0.39 -6.46 -0.33 3.6e-10 Post bronchodilator FEV1; LUSC cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.03 -0.36 1.17e-11 Colorectal cancer; LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg18404041 chr3:52824283 ITIH1 -0.55 -10.68 -0.5 4.39e-23 Bipolar disorder; LUSC cis rs35883536 0.514 rs4908062 chr1:101013211 T/C cg09408571 chr1:101003634 GPR88 0.35 6.93 0.35 2.23e-11 Monocyte count; LUSC cis rs1023500 0.529 rs133375 chr22:42466509 C/G cg15557168 chr22:42548783 NA -0.45 -6.87 -0.35 3.11e-11 Schizophrenia; LUSC cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg18132916 chr6:79620363 NA -0.38 -5.85 -0.3 1.17e-8 Intelligence (multi-trait analysis); LUSC cis rs2742234 0.590 rs1254965 chr10:43689853 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 7.03 0.36 1.17e-11 Hirschsprung disease; LUSC cis rs12621445 1 rs12621445 chr2:24154964 C/T cg08917208 chr2:24149416 ATAD2B 1.01 10.61 0.5 7.29e-23 Immature fraction of reticulocytes; LUSC cis rs7851660 0.874 rs1955143 chr9:100634579 A/T cg13688889 chr9:100608707 NA -0.57 -9.02 -0.44 1.53e-17 Strep throat; LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.78 0.47 5.09e-20 Bipolar disorder; LUSC cis rs2282300 0.739 rs7952339 chr11:30327344 C/T cg25418670 chr11:30344373 C11orf46 0.6 8.67 0.43 1.86e-16 Morning vs. evening chronotype; LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg02951883 chr7:2050386 MAD1L1 -0.52 -9.17 -0.45 4.89e-18 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs9311676 0.632 rs7643057 chr3:58374015 C/T cg13750441 chr3:58318267 PXK 0.36 6.93 0.35 2.12e-11 Systemic lupus erythematosus; LUSC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg14004847 chr7:1930337 MAD1L1 -0.52 -7.69 -0.39 1.68e-13 Bipolar disorder and schizophrenia; LUSC cis rs16949788 1.000 rs11071885 chr15:66625161 A/G cg08120210 chr15:66682733 MAP2K1 -0.58 -5.88 -0.31 1.01e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4771122 0.697 rs1475220 chr13:28037448 G/C cg22138327 chr13:27999177 GTF3A -0.66 -8.63 -0.43 2.62e-16 Body mass index; LUSC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg06453172 chr10:134556979 INPP5A -0.49 -6.25 -0.32 1.24e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.89 13.21 0.59 2.43e-32 Alzheimer's disease; LUSC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg25174290 chr11:3078921 CARS 0.61 9.17 0.45 4.94e-18 Longevity; LUSC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.44 0.42 1.01e-15 Height; LUSC cis rs13217239 0.646 rs2142685 chr6:27054497 C/T cg09904177 chr6:26538194 HMGN4 -0.51 -8.08 -0.4 1.17e-14 Schizophrenia; LUSC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg21951975 chr1:209979733 IRF6 0.59 7.0 0.36 1.38e-11 Cleft lip with or without cleft palate; LUSC cis rs250677 0.522 rs4705302 chr5:148354962 G/C cg18129178 chr5:148520854 ABLIM3 0.55 7.87 0.4 5.07e-14 Breast cancer; LUSC cis rs1008375 0.966 rs6449325 chr4:17699509 C/T cg04450456 chr4:17643702 FAM184B -0.37 -6.1 -0.32 3.02e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg18190219 chr22:46762943 CELSR1 -0.63 -6.76 -0.35 6.31e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg17971929 chr21:40555470 PSMG1 -0.68 -11.36 -0.53 1.6e-25 Cognitive function; LUSC cis rs4285028 0.699 rs1920297 chr3:121598000 T/C cg11130432 chr3:121712080 ILDR1 -0.62 -9.4 -0.46 9.2e-19 Multiple sclerosis; LUSC cis rs4604732 0.603 rs10802513 chr1:247633919 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.34 5.65 0.3 3.49e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs981844 0.740 rs7653960 chr4:154697430 T/G cg10279832 chr4:154682576 RNF175 0.36 5.65 0.3 3.43e-8 Response to statins (LDL cholesterol change); LUSC cis rs12410462 0.581 rs6675521 chr1:227544702 C/T cg04117972 chr1:227635322 NA 0.6 6.68 0.34 1e-10 Major depressive disorder; LUSC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg03060546 chr3:49711283 APEH 0.67 7.7 0.39 1.51e-13 Menarche (age at onset); LUSC cis rs6121246 0.559 rs6060915 chr20:30330306 A/G cg13852791 chr20:30311386 BCL2L1 0.87 13.36 0.59 6.74e-33 Mean corpuscular hemoglobin; LUSC cis rs7681440 0.647 rs1442136 chr4:90819026 C/T cg01966878 chr4:90757139 SNCA 0.36 5.87 0.31 1.06e-8 Dementia with Lewy bodies; LUSC cis rs7107174 1.000 rs10899483 chr11:78061057 G/C cg27205649 chr11:78285834 NARS2 -0.5 -5.65 -0.3 3.35e-8 Testicular germ cell tumor; LUSC cis rs12931792 0.782 rs6565176 chr16:30174926 T/C cg17640201 chr16:30407289 ZNF48 0.62 10.17 0.49 2.46e-21 Tonsillectomy; LUSC cis rs6964587 1.000 rs57816416 chr7:91736078 A/C cg22117172 chr7:91764530 CYP51A1 0.33 5.84 0.3 1.24e-8 Breast cancer; LUSC cis rs9905704 0.918 rs72828707 chr17:56883236 A/G cg12560992 chr17:57184187 TRIM37 0.56 8.02 0.4 1.81e-14 Testicular germ cell tumor; LUSC cis rs3213545 0.700 rs10849829 chr12:121470256 A/G cg02403541 chr12:121454288 C12orf43 -0.56 -8.56 -0.42 4.17e-16 Subjective well-being;Cardiovascular disease risk factors; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg10360139 chr7:1886902 MAD1L1 -0.4 -6.0 -0.31 5.01e-9 Bipolar disorder and schizophrenia; LUSC cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -11.25 -0.52 4.03e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1403694 0.695 rs3774292 chr3:186433574 A/T cg12454167 chr3:186435060 KNG1 0.34 8.38 0.42 1.49e-15 Blood protein levels; LUSC cis rs2040771 0.804 rs2073754 chr22:19221406 G/T cg02655711 chr22:19163373 SLC25A1 -0.47 -8.64 -0.43 2.42e-16 Metabolite levels (small molecules and protein measures); LUSC cis rs9549367 0.789 rs9549695 chr13:113874814 A/G cg18105134 chr13:113819100 PROZ 0.64 9.15 0.45 5.95e-18 Platelet distribution width; LUSC cis rs897984 0.721 rs28360557 chr16:30983260 A/C cg02466173 chr16:30829666 NA 0.55 11.21 0.52 5.56e-25 Dementia with Lewy bodies; LUSC cis rs7474896 0.559 rs2738185 chr10:38247736 G/A cg25427524 chr10:38739819 LOC399744 0.43 5.75 0.3 2.01e-8 Obesity (extreme); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07105333 chr17:27277048 PHF12 -0.45 -5.98 -0.31 5.73e-9 Hepatitis; LUSC cis rs9837602 1.000 rs10049383 chr3:99748548 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.21 -0.32 1.54e-9 Breast cancer; LUSC cis rs3820928 0.933 rs1429267 chr2:227767593 G/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.73 -0.39 1.3e-13 Pulmonary function; LUSC cis rs2997447 0.706 rs61776573 chr1:26429356 A/C cg19633962 chr1:26362018 EXTL1 -0.48 -5.64 -0.3 3.56e-8 QRS complex (12-leadsum); LUSC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg09367891 chr1:107599246 PRMT6 0.52 8.15 0.41 7.44e-15 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.56 0.5 1.11e-22 Homoarginine levels; LUSC trans rs9951602 0.512 rs4799248 chr18:76653459 G/A cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg18512352 chr11:47633146 NA -0.46 -9.21 -0.45 3.67e-18 Subjective well-being; LUSC cis rs790123 0.604 rs16834903 chr3:122379614 G/A cg00926285 chr3:122398533 PARP14 -0.41 -6.09 -0.32 3.05e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg09085632 chr11:111637200 PPP2R1B -1.05 -16.88 -0.68 1.16e-46 Primary sclerosing cholangitis; LUSC cis rs12286929 0.644 rs12099024 chr11:115082142 A/G cg04055981 chr11:115044050 NA 0.36 6.36 0.33 6.53e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7582720 1.000 rs72934704 chr2:203706433 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.75 8.16 0.41 7.08e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.69 0.34 9.34e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg00071950 chr4:10020882 SLC2A9 0.66 11.08 0.52 1.67e-24 Bone mineral density; LUSC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 9.96 0.48 1.22e-20 Personality dimensions; LUSC trans rs2204008 0.687 rs11181339 chr12:38322271 G/T cg06521331 chr12:34319734 NA -0.39 -6.23 -0.32 1.44e-9 Bladder cancer; LUSC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg17848003 chr1:3704513 LRRC47 0.34 6.15 0.32 2.18e-9 Red cell distribution width; LUSC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg24675056 chr1:15929824 NA 0.43 7.39 0.37 1.22e-12 Systolic blood pressure; LUSC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg14196790 chr5:131705035 SLC22A5 -0.43 -6.86 -0.35 3.31e-11 Breast cancer;Mosquito bite size; LUSC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg04317338 chr11:64019027 PLCB3 0.56 5.91 0.31 8.27e-9 Mean platelet volume; LUSC cis rs2652834 0.851 rs9302231 chr15:63427394 G/A cg05507819 chr15:63340323 TPM1 0.45 5.76 0.3 1.87e-8 HDL cholesterol; LUSC cis rs9914988 0.832 rs11650788 chr17:27174523 T/A cg19789473 chr17:27170043 C17orf63 -0.31 -5.85 -0.31 1.15e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs730566 0.640 rs6442112 chr3:48316034 A/G cg07636037 chr3:49044803 WDR6 0.46 5.9 0.31 8.79e-9 Prion diseases; LUSC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg24531977 chr5:56204891 C5orf35 1.0 15.06 0.64 1.73e-39 Initial pursuit acceleration; LUSC cis rs240764 0.658 rs10457849 chr6:101245591 A/G cg09795085 chr6:101329169 ASCC3 0.44 6.46 0.33 3.7e-10 Neuroticism; LUSC cis rs7385804 0.761 rs1617640 chr7:100317298 C/A cg20848291 chr7:100343083 ZAN 0.4 6.37 0.33 6.35e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs12928939 0.815 rs7185575 chr16:71672569 A/G cg08717414 chr16:71523259 ZNF19 -0.42 -5.88 -0.31 9.86e-9 Post bronchodilator FEV1; LUSC cis rs2324229 0.828 rs1180240 chr6:83937762 C/G cg08257003 chr6:84140564 ME1 0.28 6.32 0.33 8.31e-10 Platelet-derived growth factor BB levels; LUSC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg13206674 chr6:150067644 NUP43 0.64 10.48 0.5 2.17e-22 Lung cancer; LUSC trans rs7726839 0.574 rs11134149 chr5:637277 A/G cg11887960 chr12:57824829 NA 0.47 6.14 0.32 2.35e-9 Obesity-related traits; LUSC cis rs6460942 0.915 rs7803056 chr7:12306913 A/C cg06484146 chr7:12443880 VWDE -0.49 -5.9 -0.31 8.72e-9 Coronary artery disease; LUSC cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg06462663 chr19:18546047 ISYNA1 0.47 8.11 0.41 9.74e-15 Breast cancer; LUSC cis rs1448094 0.717 rs7305873 chr12:86290831 G/C cg00310523 chr12:86230176 RASSF9 0.47 8.47 0.42 7.74e-16 Major depressive disorder; LUSC trans rs8073060 0.586 rs9649 chr17:34050934 C/T cg19694781 chr19:47549865 TMEM160 1.14 18.04 0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1949733 1.000 rs2140337 chr4:8502112 A/G cg11789530 chr4:8429930 ACOX3 0.62 9.33 0.45 1.47e-18 Response to antineoplastic agents; LUSC cis rs6736093 1.000 rs1967530 chr2:112659512 A/T cg12686935 chr2:112915763 FBLN7 -0.39 -5.99 -0.31 5.37e-9 Coronary artery disease; LUSC cis rs7674212 0.510 rs55715738 chr4:104130189 A/G cg16532752 chr4:104119610 CENPE -0.44 -6.54 -0.34 2.31e-10 Type 2 diabetes; LUSC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg27121462 chr16:89883253 FANCA 0.54 8.74 0.43 1.19e-16 Vitiligo; LUSC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg24110177 chr3:50126178 RBM5 0.61 10.23 0.49 1.54e-21 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07761912 chr1:179846929 TOR1AIP2 -0.39 -6.79 -0.35 5.04e-11 Electrocardiographic conduction measures; LUSC cis rs6087771 0.662 rs6058298 chr20:30247916 C/T cg21427119 chr20:30132790 HM13 -0.39 -6.43 -0.33 4.4e-10 Subcortical brain region volumes;Putamen volume; LUSC cis rs1018836 0.886 rs10283086 chr8:91616651 G/A cg16814680 chr8:91681699 NA -0.79 -13.33 -0.59 8.65e-33 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -7.44 -0.38 8.71e-13 Chronic sinus infection; LUSC cis rs62400317 0.826 rs4544895 chr6:45271917 A/T cg20913747 chr6:44695427 NA -0.46 -7.49 -0.38 6.15e-13 Total body bone mineral density; LUSC cis rs6500395 0.926 rs11645193 chr16:48594229 C/T cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.94e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg26304593 chr6:42947056 PEX6 -0.54 -8.49 -0.42 6.8e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7212590 0.748 rs8073489 chr17:57861794 A/C cg10252138 chr17:58120427 NA -0.73 -6.91 -0.35 2.44e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg09699651 chr6:150184138 LRP11 0.38 5.87 0.31 1.08e-8 Lung cancer; LUSC cis rs34638657 0.673 rs67661146 chr16:82199669 G/A cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.55e-10 Lung adenocarcinoma; LUSC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg12463550 chr7:65579703 CRCP -0.52 -7.45 -0.38 8.06e-13 Aortic root size; LUSC cis rs728616 0.558 rs2880599 chr10:82164435 A/G cg05935833 chr10:81318306 SFTPA2 -0.44 -5.78 -0.3 1.71e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9875589 1.000 rs9875589 chr3:13961157 A/C cg19554555 chr3:13937349 NA 0.45 6.99 0.36 1.52e-11 Ovarian reserve; LUSC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg09491104 chr22:46646882 C22orf40 -0.67 -7.08 -0.36 8.7e-12 LDL cholesterol;Cholesterol, total; LUSC trans rs3733585 0.638 rs17185835 chr4:9958180 T/G cg26043149 chr18:55253948 FECH -0.46 -7.05 -0.36 1.01e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg20891283 chr12:69753455 YEATS4 0.82 14.89 0.63 8e-39 Blood protein levels; LUSC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg11752832 chr7:134001865 SLC35B4 0.56 8.68 0.43 1.73e-16 Mean platelet volume; LUSC cis rs7917772 0.582 rs10786695 chr10:104368756 A/C cg05855489 chr10:104503620 C10orf26 -0.48 -7.35 -0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7267979 1.000 rs6115146 chr20:25304507 G/A cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.71e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.62 -5.98 -0.31 5.62e-9 Cerebrospinal P-tau181p levels; LUSC cis rs3862435 0.666 rs2905963 chr15:90964891 C/T cg22089800 chr15:90895588 ZNF774 0.6 6.52 0.34 2.66e-10 Response to exercise (triglyceride level interaction); LUSC cis rs11039100 0.607 rs10838607 chr11:5778538 T/C cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs895636 1.000 rs895636 chr2:45188353 A/G cg14014731 chr9:19378679 RPS6 -0.51 -6.43 -0.33 4.3e-10 Metabolite levels;Fasting plasma glucose; LUSC cis rs1113500 0.897 rs4628530 chr1:108638708 T/G cg11967332 chr1:108735228 SLC25A24 0.39 5.92 0.31 7.96e-9 Growth-regulated protein alpha levels; LUSC cis rs28655083 1.000 rs7197078 chr16:77072735 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.38 -5.65 -0.3 3.47e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs1577917 0.538 rs6454483 chr6:86418283 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.5 7.69 0.39 1.69e-13 Response to antipsychotic treatment; LUSC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg16405210 chr4:1374714 KIAA1530 -0.49 -7.2 -0.37 3.9e-12 Obesity-related traits; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg08100565 chr3:140660748 SLC25A36 0.39 6.29 0.33 9.83e-10 Metabolite levels (Pyroglutamine); LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg06877462 chr1:205807181 PM20D1 0.54 10.18 0.49 2.2e-21 Menarche (age at onset); LUSC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg04398451 chr17:18023971 MYO15A 0.67 11.78 0.54 5.06e-27 Total body bone mineral density; LUSC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg12379764 chr21:47803548 PCNT -0.67 -9.32 -0.45 1.63e-18 Testicular germ cell tumor; LUSC cis rs73195822 0.614 rs7975139 chr12:111221131 T/C cg12870014 chr12:110450643 ANKRD13A 0.67 6.89 0.35 2.75e-11 Itch intensity from mosquito bite; LUSC cis rs10744422 1.000 rs4759387 chr12:123377569 C/T cg25930673 chr12:123319894 HIP1R -0.62 -6.1 -0.32 2.92e-9 Schizophrenia; LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.85e-12 Developmental language disorder (linguistic errors); LUSC cis rs2692947 0.550 rs4613327 chr2:96583823 G/A cg22654517 chr2:96458247 NA 0.37 6.74 0.35 6.77e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs9860340 0.730 rs1509782 chr3:87641526 C/T cg03644585 chr7:884825 UNC84A 0.42 6.03 0.31 4.35e-9 Electroencephalographic traits in alcoholism; LUSC cis rs739401 0.611 rs572373 chr11:3055361 T/C cg05729581 chr11:3078854 CARS -0.53 -7.97 -0.4 2.55e-14 Longevity; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg09523086 chr21:33984856 C21orf59 -0.5 -6.59 -0.34 1.74e-10 Hepatitis; LUSC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg24531977 chr5:56204891 C5orf35 -1.02 -15.45 -0.65 5.12e-41 Initial pursuit acceleration; LUSC cis rs7618501 1.000 rs2271961 chr3:49878113 C/T cg13072238 chr3:49761600 GMPPB -0.37 -6.14 -0.32 2.3e-9 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.11 -0.58 5.82e-32 Platelet count; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg18681998 chr4:17616180 MED28 0.85 15.88 0.66 1.07e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9467711 0.606 rs68112369 chr6:26365759 T/C cg09904177 chr6:26538194 HMGN4 -0.73 -6.85 -0.35 3.67e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg19046167 chr17:80928561 B3GNTL1 0.49 7.1 0.36 7.62e-12 Glycated hemoglobin levels; LUSC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg09365446 chr1:150670422 GOLPH3L 0.52 7.98 0.4 2.3e-14 Tonsillectomy; LUSC cis rs10089 1.000 rs4835944 chr5:127490870 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.77 -10.36 -0.49 5.21e-22 Ileal carcinoids; LUSC cis rs394563 0.591 rs237018 chr6:149743930 A/G cg07828024 chr6:149772892 ZC3H12D -0.33 -7.31 -0.37 2.05e-12 Dupuytren's disease; LUSC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg22823121 chr1:150693482 HORMAD1 0.51 7.56 0.38 4.03e-13 Melanoma; LUSC cis rs6545977 0.531 rs2539981 chr2:63104904 T/C cg17519650 chr2:63277830 OTX1 0.74 10.94 0.51 5.14e-24 Prostate cancer; LUSC cis rs6570726 1.000 rs373778 chr6:145873252 C/T cg05347473 chr6:146136440 FBXO30 0.41 7.0 0.36 1.4e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs7911712 0.515 rs1771996 chr10:45258544 T/C cg04948906 chr11:124413229 OR8B12 0.46 6.04 0.31 4.18e-9 Emphysema-related traits; LUSC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg12257692 chr3:49977190 RBM6 -0.26 -7.24 -0.37 3.2e-12 Body mass index; LUSC trans rs8072100 0.905 rs9901869 chr17:45575206 G/A cg04995722 chr7:26192034 NFE2L3 -0.39 -6.38 -0.33 6.03e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6502050 0.734 rs7217625 chr17:80157766 T/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.81e-10 Life satisfaction; LUSC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.93 14.88 0.63 9.31e-39 Multiple sclerosis; LUSC cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg24642439 chr20:33292090 TP53INP2 0.51 7.64 0.39 2.32e-13 Height; LUSC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.13e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs5760092 0.755 rs915589 chr22:24261004 C/T cg06437703 chr8:37914619 EIF4EBP1 0.54 6.97 0.36 1.69e-11 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs6733011 0.500 rs2280142 chr2:99434872 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.78 -0.3 1.67e-8 Bipolar disorder; LUSC cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.63 0.86 5.12e-99 Chronic sinus infection; LUSC cis rs12042938 1.000 rs823158 chr1:231782650 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 5.99 0.31 5.36e-9 Neuranatomic and neurocognitive phenotypes; LUSC trans rs7824557 0.628 rs11777746 chr8:11204755 T/C cg08975724 chr8:8085496 FLJ10661 0.43 6.12 0.32 2.56e-9 Retinal vascular caliber; LUSC cis rs2286885 1.000 rs10819169 chr9:129249625 C/T cg15282417 chr9:129245246 FAM125B 0.38 6.33 0.33 7.96e-10 Intraocular pressure; LUSC trans rs7824557 0.564 rs2572392 chr8:11235605 T/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.01e-14 Retinal vascular caliber; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06588483 chr12:42877540 PRICKLE1 0.77 5.98 0.31 5.67e-9 Cognitive performance; LUSC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg06873352 chr17:61820015 STRADA 0.56 8.57 0.42 3.99e-16 Height; LUSC trans rs7980799 0.716 rs1351683 chr12:33598563 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.49 -0.33 3.1e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg23887609 chr12:130822674 PIWIL1 0.46 6.64 0.34 1.3100000000000001e-10 Menopause (age at onset); LUSC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg18876405 chr7:65276391 NA 0.75 13.71 0.6 3.03e-34 Calcium levels; LUSC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg14440974 chr22:39074834 NA -0.35 -5.87 -0.31 1.02e-8 Menopause (age at onset); LUSC cis rs72634258 0.554 rs68024107 chr1:7914066 G/C cg26816564 chr1:7831052 VAMP3 0.7 9.63 0.47 1.54e-19 Inflammatory bowel disease; LUSC cis rs7103648 1.000 rs2293579 chr11:47440758 G/A cg20307385 chr11:47447363 PSMC3 1.0 19.73 0.73 5.26e-58 Diastolic blood pressure;Systolic blood pressure; LUSC trans rs7824557 0.564 rs2736302 chr8:11236419 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.66e-10 Retinal vascular caliber; LUSC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg09267113 chr7:98030324 BAIAP2L1 0.4 5.96 0.31 6.35e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg13072238 chr3:49761600 GMPPB -0.36 -5.88 -0.31 9.99e-9 Body mass index; LUSC trans rs7615952 0.546 rs112919177 chr3:125346070 G/A cg07211511 chr3:129823064 LOC729375 -0.53 -6.08 -0.32 3.25e-9 Blood pressure (smoking interaction); LUSC cis rs4363385 0.510 rs6689510 chr1:153048039 G/A cg25856811 chr1:152973957 SPRR3 -0.38 -6.23 -0.32 1.43e-9 Inflammatory skin disease; LUSC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.5 0.33 2.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2933343 0.700 rs789239 chr3:128633808 T/C cg11901034 chr3:128598214 ACAD9 -0.42 -6.69 -0.34 9.27e-11 IgG glycosylation; LUSC cis rs78456975 0.941 rs13423300 chr2:1553809 C/A cg01028140 chr2:1542097 TPO -0.62 -7.98 -0.4 2.43e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs10504229 0.679 rs2218271 chr8:58052446 T/A cg21724239 chr8:58056113 NA 0.55 6.55 0.34 2.17e-10 Developmental language disorder (linguistic errors); LUSC cis rs7954584 0.813 rs12827200 chr12:122451278 G/A cg10207240 chr12:122356781 WDR66 0.4 5.75 0.3 1.98e-8 Mean corpuscular volume; LUSC cis rs9325144 0.600 rs10785621 chr12:38744912 C/T cg26384229 chr12:38710491 ALG10B 0.6 9.51 0.46 3.96e-19 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg26924012 chr15:45694286 SPATA5L1 1.14 20.41 0.75 1.08e-60 Homoarginine levels; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg09877947 chr5:131593287 PDLIM4 0.45 7.04 0.36 1.07e-11 Acylcarnitine levels; LUSC cis rs7147624 0.608 rs4902413 chr14:66187091 T/C cg03016385 chr14:66212404 NA -0.79 -8.56 -0.42 4.19e-16 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4714291 0.855 rs1743971 chr6:40095927 A/C cg02267698 chr19:7991119 CTXN1 0.53 7.4 0.38 1.11e-12 Strep throat; LUSC cis rs11039100 1.000 rs61875914 chr11:5828299 T/G cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7771547 0.607 rs9348997 chr6:36430560 A/G cg07856975 chr6:36356162 ETV7 -0.37 -6.53 -0.34 2.5e-10 Platelet distribution width; LUSC cis rs250677 0.522 rs6580590 chr5:148360374 C/T cg18129178 chr5:148520854 ABLIM3 0.52 7.36 0.37 1.41e-12 Breast cancer; LUSC cis rs4919694 0.901 rs12251035 chr10:104671459 A/C cg04362960 chr10:104952993 NT5C2 1.15 13.39 0.59 5.24e-33 Arsenic metabolism; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25875824 chr1:29063431 YTHDF2 -0.4 -6.0 -0.31 5.01e-9 Electrocardiographic conduction measures; LUSC cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg01849466 chr14:104193079 ZFYVE21 -0.55 -8.73 -0.43 1.28e-16 Schizophrenia; LUSC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg00166722 chr3:10149974 C3orf24 0.4 5.91 0.31 8.24e-9 Alzheimer's disease; LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.66 0.6 4.84e-34 Platelet count; LUSC cis rs68092024 0.704 rs704575 chr3:99486075 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 6.34 0.33 7.66e-10 Cleft lip with or without cleft palate; LUSC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg18404041 chr3:52824283 ITIH1 -0.51 -9.76 -0.47 5.98e-20 Bipolar disorder; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.67 0.39 1.94e-13 Prudent dietary pattern; LUSC cis rs10761482 0.861 rs7085259 chr10:62107418 T/G cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC cis rs1801251 1.000 rs283475 chr2:233654381 A/C cg25237894 chr2:233734115 C2orf82 -0.34 -5.99 -0.31 5.31e-9 Coronary artery disease; LUSC cis rs950776 0.518 rs12907169 chr15:78825498 G/C cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs17661538 0.504 rs35667846 chr10:18464913 G/A cg03634479 chr10:18430412 CACNB2 0.63 5.86 0.31 1.11e-8 Response to antipsychotic treatment; LUSC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19717773 chr7:2847554 GNA12 -0.36 -5.91 -0.31 8.38e-9 Height; LUSC cis rs11098499 0.615 rs28551750 chr4:120264901 C/T cg24375607 chr4:120327624 NA 0.7 11.14 0.52 1.03e-24 Corneal astigmatism; LUSC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.52 7.4 0.38 1.13e-12 Tuberculosis; LUSC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg23985595 chr17:80112537 CCDC57 0.31 5.93 0.31 7.45e-9 Life satisfaction; LUSC cis rs2404602 0.647 rs7181506 chr15:76935677 G/T cg23625390 chr15:77176239 SCAPER 0.64 9.52 0.46 3.66e-19 Blood metabolite levels; LUSC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg16060761 chr17:80687452 NA 0.42 6.5 0.34 2.87e-10 Breast cancer; LUSC trans rs11039798 0.660 rs28435129 chr11:48629795 A/T cg15704280 chr7:45808275 SEPT13 0.66 7.32 0.37 1.82e-12 Axial length; LUSC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -6.03 -0.31 4.35e-9 Intelligence (multi-trait analysis); LUSC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.4 6.04 0.31 4.15e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs9325144 0.681 rs7957376 chr12:39096518 C/T cg26384229 chr12:38710491 ALG10B 0.51 6.56 0.34 2.04e-10 Morning vs. evening chronotype; LUSC cis rs62400317 0.723 rs755 chr6:44795790 C/T cg18551225 chr6:44695536 NA -0.47 -7.5 -0.38 5.8e-13 Total body bone mineral density; LUSC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg25622487 chr11:95524042 FAM76B;CEP57 0.82 12.18 0.55 1.71e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs62238980 0.614 rs77511414 chr22:32406941 A/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs17270561 0.639 rs9356989 chr6:25781950 A/G cg17691542 chr6:26056736 HIST1H1C 0.52 7.23 0.37 3.22e-12 Iron status biomarkers; LUSC cis rs2732480 0.500 rs7297824 chr12:48598650 T/C cg04545296 chr12:48745243 ZNF641 0.33 6.21 0.32 1.57e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs4081724 0.638 rs17602094 chr19:33848683 A/T cg15602950 chr3:45731220 SACM1L -0.52 -6.1 -0.32 3e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg01657329 chr11:68192670 LRP5 -0.44 -7.1 -0.36 7.71e-12 Total body bone mineral density; LUSC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg23583168 chr7:148888333 NA -0.87 -16.03 -0.66 2.6900000000000002e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7771547 0.519 rs28371845 chr6:36377709 C/T cg07856975 chr6:36356162 ETV7 0.44 6.38 0.33 5.9e-10 Platelet distribution width; LUSC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.01 0.4 1.9e-14 Parkinson's disease; LUSC cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -12.67 -0.57 2.7e-30 Type 2 diabetes; LUSC cis rs11122272 0.735 rs2355872 chr1:231478489 A/T cg06096015 chr1:231504339 EGLN1 0.53 9.06 0.44 1.1e-17 Hemoglobin concentration; LUSC cis rs7512552 0.839 rs2873669 chr1:150426224 C/T cg15654264 chr1:150340011 RPRD2 -0.64 -10.73 -0.51 2.85e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg06808227 chr14:105710500 BRF1 -0.69 -10.89 -0.51 7.74e-24 Mean platelet volume;Platelet distribution width; LUSC trans rs7374394 1.000 rs2301052 chr3:184953662 C/T cg02182827 chr1:51808561 TTC39A 0.36 6.0 0.31 5.26e-9 Cognitive performance; LUSC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg16743903 chr16:89593216 SPG7 -0.37 -5.88 -0.31 9.84e-9 Multiple myeloma (IgH translocation); LUSC cis rs4780401 0.609 rs4781143 chr16:11809721 T/G cg01061890 chr16:11836724 TXNDC11 -0.56 -8.63 -0.43 2.54e-16 Rheumatoid arthritis; LUSC cis rs34311866 0.808 rs11248059 chr4:960331 C/G cg07828340 chr4:882639 GAK 0.97 9.61 0.47 1.8e-19 Parkinson's disease; LUSC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.99 0.4 2.22e-14 Bipolar disorder; LUSC cis rs2658782 0.789 rs2658773 chr11:93126914 A/G cg15737290 chr11:93063684 CCDC67 0.64 7.92 0.4 3.59e-14 Pulmonary function decline; LUSC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.16e-9 Diabetic kidney disease; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg26354017 chr1:205819088 PM20D1 0.84 15.09 0.64 1.35e-39 Menarche (age at onset); LUSC cis rs7208859 0.623 rs9890855 chr17:29111707 G/C cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg03264133 chr6:25882463 NA -0.86 -16.38 -0.67 1.17e-44 Urate levels; LUSC cis rs117623576 0.941 rs211422 chr10:32398589 A/G cg03047570 chr10:32398778 NA 0.73 7.86 0.4 5.39e-14 Anti-saccade response; LUSC trans rs656319 0.629 rs10111315 chr8:9865588 G/A cg15556689 chr8:8085844 FLJ10661 -0.44 -6.5 -0.34 2.85e-10 Myopia (pathological); LUSC cis rs13082711 0.911 rs35904501 chr3:27443317 T/C cg02860705 chr3:27208620 NA 0.48 7.91 0.4 3.7e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs2562456 0.833 rs55790393 chr19:21506184 A/T cg00806126 chr19:22604979 ZNF98 -0.42 -5.99 -0.31 5.56e-9 Pain; LUSC cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg07148914 chr20:33460835 GGT7 0.54 8.4 0.42 1.33e-15 Height; LUSC cis rs73206853 0.764 rs55859138 chr12:110775610 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs12776158 0.901 rs35355528 chr10:71216268 A/G cg12610070 chr10:71211762 TSPAN15 -0.46 -6.05 -0.31 3.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.58 0.38 3.37e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg03188948 chr7:1209495 NA 0.67 7.1 0.36 7.38e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg22963979 chr7:1858916 MAD1L1 -0.59 -8.98 -0.44 1.96e-17 Bipolar disorder and schizophrenia; LUSC cis rs7582180 0.568 rs10186134 chr2:100939501 T/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.57 -0.42 4e-16 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs2625529 0.652 rs2929518 chr15:72332748 A/C cg16672083 chr15:72433130 SENP8 0.49 8.12 0.41 9.35e-15 Red blood cell count; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.46 0.78 9.92e-69 Prudent dietary pattern; LUSC cis rs36093844 0.752 rs74404559 chr11:85565669 G/A cg25872744 chr11:85566296 CCDC83 -0.45 -5.78 -0.3 1.68e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs10992471 0.603 rs7865019 chr9:95325631 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.81 -0.35 4.47e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9467773 0.967 rs6932865 chr6:26540166 C/A cg09904177 chr6:26538194 HMGN4 0.75 14.27 0.62 2.07e-36 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg11366901 chr6:160182831 ACAT2 0.94 12.53 0.57 8.85e-30 Age-related macular degeneration (geographic atrophy); LUSC trans rs4332037 0.851 rs73050128 chr7:1961882 C/A cg25206134 chr2:45395956 NA 0.59 6.79 0.35 5.26e-11 Bipolar disorder; LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg12564285 chr5:131593104 PDLIM4 0.49 8.68 0.43 1.72e-16 Acylcarnitine levels; LUSC trans rs3808502 0.527 rs4410870 chr8:11156120 C/G cg15556689 chr8:8085844 FLJ10661 -0.43 -6.36 -0.33 6.69e-10 Neuroticism; LUSC cis rs11785400 0.731 rs9720504 chr8:143725502 T/C cg10596483 chr8:143751796 JRK 0.52 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg03354898 chr7:1950403 MAD1L1 -0.36 -7.13 -0.36 6.41e-12 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 12.4 0.56 2.72e-29 Prudent dietary pattern; LUSC trans rs11098499 0.954 rs3733523 chr4:120423719 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs9517320 0.534 rs3858776 chr13:99161457 C/T cg07423050 chr13:99094983 FARP1 -0.45 -8.57 -0.42 3.77e-16 Longevity; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg18758796 chr5:131593413 PDLIM4 0.4 7.07 0.36 9.38e-12 Blood metabolite levels; LUSC cis rs9650315 0.929 rs11988517 chr8:57181143 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.8 0.35 4.85e-11 Height; LUSC trans rs62238980 0.614 rs17744899 chr22:32406766 G/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs4595586 0.545 rs6580888 chr12:39369704 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.96 0.31 6.32e-9 Morning vs. evening chronotype; LUSC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg05623727 chr3:50126028 RBM5 -0.34 -6.36 -0.33 6.59e-10 Intelligence (multi-trait analysis); LUSC cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg13535736 chr9:111863775 C9orf5 -0.42 -6.9 -0.35 2.56e-11 Menarche (age at onset); LUSC cis rs113835537 0.529 rs3819247 chr11:66293779 T/C cg24851651 chr11:66362959 CCS 0.55 8.06 0.4 1.33e-14 Airway imaging phenotypes; LUSC cis rs1008375 1.000 rs9291659 chr4:17662360 A/C cg04450456 chr4:17643702 FAM184B 0.4 6.74 0.35 6.94e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21582582 chr3:182698605 DCUN1D1 0.46 8.19 0.41 5.64e-15 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg22920501 chr2:26401640 FAM59B -0.77 -11.45 -0.53 8.11e-26 Gut microbiome composition (summer); LUSC cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg22681709 chr2:178499509 PDE11A -0.51 -8.94 -0.44 2.61e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg04518342 chr5:131593106 PDLIM4 -0.45 -7.53 -0.38 4.66e-13 Blood metabolite levels; LUSC cis rs9837602 1.000 rs7627991 chr3:99808338 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.71 -0.3 2.49e-8 Breast cancer; LUSC cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg14844989 chr11:31128820 NA -0.37 -5.76 -0.3 1.95e-8 Red blood cell count; LUSC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg11764359 chr7:65958608 NA -0.68 -10.47 -0.5 2.3e-22 Aortic root size; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg11494091 chr17:61959527 GH2 0.7 14.63 0.62 8.79e-38 Prudent dietary pattern; LUSC cis rs907683 0.584 rs12920 chr2:220285666 C/G cg15015639 chr2:220282977 DES 0.3 6.96 0.36 1.86e-11 Resting heart rate; LUSC cis rs7106204 0.514 rs12805363 chr11:24258357 T/G ch.11.24196551F chr11:24239977 NA 0.73 6.22 0.32 1.49e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg04414720 chr1:150670196 GOLPH3L 0.53 8.11 0.41 1e-14 Melanoma; LUSC trans rs9291683 0.588 rs11732054 chr4:9999877 C/T cg26043149 chr18:55253948 FECH 0.48 6.99 0.36 1.48e-11 Bone mineral density; LUSC cis rs9527 0.590 rs1807298 chr10:104870218 G/A cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs11785400 1.000 rs3735994 chr8:143742683 C/T cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs1372520 0.873 rs2583990 chr4:90771499 A/G cg14346243 chr4:90757452 SNCA -0.41 -5.97 -0.31 5.97e-9 Neuroticism; LUSC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7954584 0.813 rs11043288 chr12:122451187 C/T cg22618164 chr12:122356400 WDR66 -0.51 -7.49 -0.38 6.2e-13 Mean corpuscular volume; LUSC cis rs17075286 1 rs17075286 chr3:43230723 C/G cg05881034 chr3:42623675 SEC22C -0.49 -6.39 -0.33 5.48e-10 Bipolar disorder and schizophrenia; LUSC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.08 0.4 1.19e-14 Parkinson's disease; LUSC cis rs9937943 0.564 rs74820302 chr16:74698252 A/T cg01733217 chr16:74700730 RFWD3 0.66 7.81 0.39 7.44e-14 Neutrophil percentage of white cells; LUSC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg09491104 chr22:46646882 C22orf40 -0.7 -6.2 -0.32 1.67e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg16447950 chr5:562315 NA -0.59 -7.06 -0.36 9.96e-12 Lung disease severity in cystic fibrosis; LUSC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg15494558 chr6:150152522 LRP11 0.33 5.72 0.3 2.4e-8 Lung cancer; LUSC cis rs6740322 0.748 rs6727631 chr2:43470408 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -6.48 -0.33 3.23e-10 Coronary artery disease; LUSC cis rs6430585 0.583 rs7561565 chr2:136640787 A/C cg07169764 chr2:136633963 MCM6 1.12 16.95 0.68 6.26e-47 Corneal structure; LUSC trans rs6601327 0.641 rs10102170 chr8:9611470 C/T cg15556689 chr8:8085844 FLJ10661 0.48 6.67 0.34 1.05e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg04414720 chr1:150670196 GOLPH3L 0.54 8.46 0.42 8.59e-16 Melanoma; LUSC cis rs9549367 0.712 rs2316443 chr13:113864837 G/A cg00898013 chr13:113819073 PROZ -0.58 -8.8 -0.43 7.44e-17 Platelet distribution width; LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg08470875 chr2:26401718 FAM59B -0.69 -9.35 -0.46 1.28e-18 Gut microbiome composition (summer); LUSC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg17376030 chr22:41985996 PMM1 -0.48 -5.9 -0.31 8.9e-9 Vitiligo; LUSC cis rs10140922 0.966 rs4982259 chr14:35821950 T/C cg07166546 chr14:35805898 NA -0.24 -5.89 -0.31 9.53e-9 Hip circumference adjusted for BMI; LUSC cis rs2762353 0.935 rs1165213 chr6:25799676 A/G cg03264133 chr6:25882463 NA 0.39 6.91 0.35 2.47e-11 Blood metabolite levels; LUSC cis rs394563 0.601 rs382720 chr6:149795261 C/T cg07828024 chr6:149772892 ZC3H12D 0.38 7.86 0.39 5.49e-14 Dupuytren's disease; LUSC trans rs6951245 1.000 rs76388414 chr7:1100694 G/A cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11098499 0.908 rs7695996 chr4:120322033 C/T cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs2760061 0.626 rs2527615 chr1:228119283 A/G cg01973587 chr1:228161476 NA 0.44 7.98 0.4 2.35e-14 Diastolic blood pressure; LUSC cis rs2219968 0.770 rs12545292 chr8:78886841 A/T cg00738934 chr8:78996279 NA -0.39 -6.95 -0.36 1.93e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9868809 0.656 rs13324119 chr3:48710606 G/C cg00383909 chr3:49044727 WDR6 1.08 9.51 0.46 3.95e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13763729 chr18:5294883 ZFP161 -0.47 -6.2 -0.32 1.67e-9 Bipolar disorder and schizophrenia; LUSC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg23281280 chr6:28129359 ZNF389 -0.44 -5.77 -0.3 1.8e-8 Depression; LUSC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg11645453 chr3:52864694 ITIH4 0.33 7.57 0.38 3.67e-13 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg20608306 chr11:116969690 SIK3 -0.33 -6.14 -0.32 2.35e-9 Blood protein levels; LUSC cis rs6495122 0.501 rs6495144 chr15:75343438 T/C cg14664628 chr15:75095509 CSK 0.42 6.02 0.31 4.6e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg16606324 chr3:10149918 C3orf24 0.58 8.23 0.41 4.27e-15 Alzheimer's disease; LUSC cis rs9309473 1.000 rs7564890 chr2:73641853 T/C cg20560298 chr2:73613845 ALMS1 -0.43 -6.18 -0.32 1.88e-9 Metabolite levels; LUSC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg07936489 chr17:37558343 FBXL20 0.86 11.31 0.53 2.52e-25 Glomerular filtration rate (creatinine); LUSC trans rs3889199 0.740 rs7412276 chr1:59667721 A/C cg24327262 chr19:46929907 NA -0.39 -6.09 -0.32 3.09e-9 Pulse pressure; LUSC cis rs2370759 1.000 rs16933177 chr10:32565705 G/A cg01819863 chr10:32635814 EPC1 1.07 13.4 0.59 4.64e-33 Sexual dysfunction (female); LUSC cis rs2721195 0.549 rs2620666 chr8:145703413 T/C cg15320075 chr8:145703422 NA 0.66 11.33 0.53 2.16e-25 Age at first birth; LUSC cis rs4805272 0.539 rs7256211 chr19:29333063 C/G cg12756686 chr19:29218302 NA 0.53 6.19 0.32 1.74e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9309473 1.000 rs9309473 chr2:73743982 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.56 -0.34 2.06e-10 Metabolite levels; LUSC cis rs5769765 0.908 rs138864 chr22:50204712 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.73 -9.56 -0.46 2.6e-19 Schizophrenia; LUSC cis rs7215564 0.818 rs78905718 chr17:78604278 G/A cg23238734 chr17:78661607 RPTOR 0.44 5.79 0.3 1.65e-8 Myopia (pathological); LUSC trans rs11681884 0.892 rs72950867 chr2:113858671 A/G cg09636715 chr7:27217057 HOXA10 0.73 6.04 0.31 4.16e-9 Stroke; LUSC cis rs3741151 0.686 rs7123985 chr11:73260463 A/C cg17517138 chr11:73019481 ARHGEF17 0.82 7.67 0.39 1.9e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg03233332 chr7:66118400 NA 0.41 5.94 0.31 7.17e-9 Aortic root size; LUSC cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg22532475 chr10:104410764 TRIM8 -0.35 -7.71 -0.39 1.43e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg03929089 chr4:120376271 NA -0.45 -6.12 -0.32 2.58e-9 HDL cholesterol; LUSC cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg13010199 chr12:38710504 ALG10B 0.69 11.45 0.53 7.93e-26 Heart rate; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg07362569 chr17:61921086 SMARCD2 0.38 7.7 0.39 1.61e-13 Prudent dietary pattern; LUSC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg03060546 chr3:49711283 APEH 0.72 12.22 0.56 1.2e-28 Resting heart rate; LUSC cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg22455342 chr2:225449267 CUL3 0.83 11.31 0.53 2.5e-25 IgE levels in asthmatics (D.p. specific); LUSC cis rs2073300 0.609 rs6137945 chr20:23406136 C/T cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4704187 0.617 rs1477936 chr5:74448502 T/A cg03227963 chr5:74354835 NA 0.32 6.91 0.35 2.44e-11 Response to amphetamines; LUSC trans rs4295623 0.559 rs4841600 chr8:11688148 T/C cg06636001 chr8:8085503 FLJ10661 0.51 7.31 0.37 1.98e-12 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.87 0.4 5.07e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg22875332 chr1:76189707 ACADM 0.64 9.1 0.45 8.36e-18 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6964587 0.869 rs2013334 chr7:91549657 G/A cg22709100 chr7:91322751 NA -0.39 -5.83 -0.3 1.33e-8 Breast cancer; LUSC cis rs11676348 0.811 rs13027120 chr2:219020914 C/T cg00012203 chr2:219082015 ARPC2 0.59 9.89 0.48 2.19e-20 Ulcerative colitis; LUSC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg05585544 chr11:47624801 NA -0.4 -6.91 -0.35 2.44e-11 Subjective well-being; LUSC cis rs9747201 1.000 rs3922470 chr17:80110159 C/T cg18209359 chr17:80159595 CCDC57 0.38 6.45 0.33 4e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs79911532 0.515 rs117690214 chr7:75718237 C/T cg03592824 chr7:75666768 STYXL1 0.67 6.41 0.33 4.98e-10 Mononucleosis; LUSC trans rs11764590 0.950 rs11514731 chr7:2051503 C/G cg25206134 chr2:45395956 NA 0.63 7.25 0.37 2.9e-12 Neuroticism; LUSC trans rs225245 0.782 rs321617 chr17:33915246 A/G cg19694781 chr19:47549865 TMEM160 -0.42 -6.65 -0.34 1.18e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg18904891 chr8:8559673 CLDN23 0.4 6.08 0.32 3.35e-9 Mood instability; LUSC trans rs2392780 0.667 rs432470 chr8:128339044 C/T cg10195415 chr17:73887371 TRIM65 0.42 6.65 0.34 1.19e-10 Breast cancer (early onset); LUSC cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.85 10.76 0.51 2.21e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1577917 1.000 rs12190598 chr6:86686074 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.41 -5.86 -0.31 1.1e-8 Response to antipsychotic treatment; LUSC cis rs367943 0.712 rs7734304 chr5:112730165 G/A cg12552261 chr5:112820674 MCC 0.37 6.11 0.32 2.72e-9 Type 2 diabetes; LUSC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg21132104 chr15:45694354 SPATA5L1 0.56 7.82 0.39 7.06e-14 Homoarginine levels; LUSC trans rs7819412 0.775 rs4841489 chr8:10936811 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.83 -0.35 4.03e-11 Triglycerides; LUSC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg15556689 chr8:8085844 FLJ10661 0.58 8.56 0.42 4.29e-16 Neuroticism; LUSC cis rs12368653 0.525 rs1564374 chr12:58010163 C/T cg12615879 chr12:58013172 SLC26A10 0.42 10.38 0.49 4.68e-22 Multiple sclerosis; LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg22166914 chr1:53195759 ZYG11B 0.61 10.32 0.49 7.26e-22 Monocyte count; LUSC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg08270630 chr22:50330655 NA -0.44 -6.62 -0.34 1.43e-10 Schizophrenia; LUSC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg11644478 chr21:40555479 PSMG1 0.71 9.18 0.45 4.71e-18 Cognitive function; LUSC trans rs6951245 0.580 rs77101766 chr7:1122438 A/G cg13565492 chr6:43139072 SRF -0.73 -10.59 -0.5 8.78e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18404041 chr3:52824283 ITIH1 -0.5 -9.57 -0.46 2.44e-19 Electroencephalogram traits; LUSC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg10792982 chr14:105748885 BRF1 -0.47 -8.71 -0.43 1.44e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg23601095 chr6:26197514 HIST1H3D 0.69 7.36 0.37 1.45e-12 Gout;Renal underexcretion gout; LUSC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.4 -5.99 -0.31 5.42e-9 Menarche (age at onset); LUSC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23221052 chr5:179740743 GFPT2 -0.62 -9.78 -0.47 4.96e-20 Height; LUSC cis rs10392 0.543 rs2867240 chr20:37538354 C/T cg27552599 chr20:37590471 DHX35 0.42 6.67 0.34 1.09e-10 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18864164 chr10:115934049 MIR2110;C10orf118 0.45 6.38 0.33 6.04e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg22875332 chr1:76189707 ACADM -0.73 -10.1 -0.48 4.22e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12618769 0.570 rs17032866 chr2:99132415 A/G cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg00684032 chr4:1343700 KIAA1530 0.37 6.5 0.34 2.89e-10 Obesity-related traits; LUSC cis rs1982963 0.627 rs3783632 chr14:52498111 C/A cg10843707 chr14:52510701 NID2 0.47 6.3 0.33 9.23e-10 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs208520 0.955 rs17644076 chr6:67004973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.81 -10.31 -0.49 8.18e-22 Exhaled nitric oxide output; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03586379 chr3:140660603 SLC25A36 -0.48 -6.08 -0.32 3.24e-9 Bipolar disorder and schizophrenia; LUSC cis rs9325144 0.600 rs34138871 chr12:38735261 A/G cg26384229 chr12:38710491 ALG10B 0.6 9.48 0.46 4.93e-19 Morning vs. evening chronotype; LUSC cis rs76878669 0.606 rs2282531 chr11:66099494 C/T cg18002602 chr11:66138449 SLC29A2 -0.47 -8.47 -0.42 8.19e-16 Educational attainment (years of education); LUSC cis rs7843479 0.582 rs7009693 chr8:21775314 C/T cg17168535 chr8:21777572 XPO7 0.77 13.88 0.6 6.9e-35 Mean corpuscular volume; LUSC cis rs6430585 0.528 rs3099429 chr2:136655582 T/A cg07169764 chr2:136633963 MCM6 1.08 16.53 0.67 2.91e-45 Corneal structure; LUSC trans rs11039798 0.582 rs1483119 chr11:48382334 A/G cg03929089 chr4:120376271 NA -0.59 -6.29 -0.33 9.96e-10 Axial length; LUSC cis rs929354 0.742 rs6956046 chr7:156962874 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.56 -0.46 2.61e-19 Body mass index; LUSC cis rs7223966 0.960 rs113155878 chr17:61706560 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.7 0.34 8.72e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs73200209 0.626 rs56159711 chr12:116578050 T/C cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs9467711 0.720 rs7749823 chr6:26158079 A/C cg16898833 chr6:26189333 HIST1H4D 0.71 7.15 0.36 5.5e-12 Autism spectrum disorder or schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg07898084 chr13:53029385 CKAP2 0.45 6.32 0.33 8.15e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7561273 0.586 rs9309225 chr2:24292863 T/C cg20701182 chr2:24300061 SF3B14 0.45 5.77 0.3 1.76e-8 Quantitative traits; LUSC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs983392 0.679 rs636341 chr11:60019161 A/C cg02771260 chr11:59836817 MS4A3 0.37 6.1 0.32 3.02e-9 Alzheimer's disease (late onset); LUSC cis rs4851313 0.527 rs10183150 chr2:100939117 A/G cg08017756 chr2:100939284 LONRF2 -0.43 -8.03 -0.4 1.69e-14 Intelligence (multi-trait analysis); LUSC cis rs9393692 0.645 rs11756673 chr6:26323505 A/G cg00631329 chr6:26305371 NA -0.54 -10.61 -0.5 7.47e-23 Educational attainment; LUSC cis rs9039 1.000 rs56193985 chr16:9207199 C/A cg08831531 chr16:9218945 NA -0.67 -10.39 -0.49 4.22e-22 Menopause (age at onset); LUSC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg21960279 chr19:17905606 B3GNT3 0.38 6.0 0.31 5.2e-9 Tumor biomarkers; LUSC cis rs2019216 0.542 rs1850564 chr17:21911794 T/C cg22648282 chr17:21454238 C17orf51 -0.52 -7.8 -0.39 7.82e-14 Pelvic organ prolapse; LUSC cis rs6598955 0.724 rs7547520 chr1:26592310 C/T cg04990556 chr1:26633338 UBXN11 -0.8 -14.87 -0.63 9.73e-39 Obesity-related traits; LUSC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs3809566 0.963 rs3809565 chr15:63333619 A/G cg05507819 chr15:63340323 TPM1 0.62 8.39 0.42 1.42e-15 Platelet count; LUSC trans rs62238980 0.614 rs117185558 chr22:32403523 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs79976124 0.879 rs77185357 chr6:66629070 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.67 8.31 0.41 2.48e-15 Type 2 diabetes; LUSC cis rs7726839 0.540 rs72703080 chr5:595238 A/G cg09021430 chr5:549028 NA -0.56 -7.36 -0.37 1.41e-12 Obesity-related traits; LUSC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg10253484 chr15:75165896 SCAMP2 -0.47 -6.61 -0.34 1.52e-10 Breast cancer; LUSC trans rs800082 0.507 rs2222701 chr3:144258813 C/T cg24215973 chr2:240111563 HDAC4 0.48 7.48 0.38 6.75e-13 Smoking behavior; LUSC cis rs611744 0.647 rs1609472 chr8:109269232 T/G cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.17e-10 Dupuytren's disease; LUSC cis rs9325144 0.647 rs7957185 chr12:38909710 G/A cg13010199 chr12:38710504 ALG10B -0.48 -7.23 -0.37 3.28e-12 Morning vs. evening chronotype; LUSC cis rs6964587 0.839 rs17731846 chr7:91440342 A/G cg22709100 chr7:91322751 NA 0.44 6.44 0.33 4.07e-10 Breast cancer; LUSC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg04518342 chr5:131593106 PDLIM4 0.37 6.87 0.35 3.15e-11 Blood metabolite levels; LUSC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg16240275 chr20:61666158 NCRNA00029 0.42 9.39 0.46 9.76e-19 Prostate cancer (SNP x SNP interaction); LUSC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.75 10.92 0.51 6.24e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg12863693 chr15:85201151 NMB 0.34 6.13 0.32 2.45e-9 Schizophrenia; LUSC cis rs9314323 0.698 rs1064807 chr8:26236978 C/T cg13160058 chr8:26243215 BNIP3L -0.42 -7.63 -0.39 2.56e-13 Red cell distribution width; LUSC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg12386194 chr3:101231763 SENP7 0.64 8.64 0.43 2.35e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9811920 0.809 rs4928150 chr3:99685991 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.91 0.35 2.41e-11 Axial length; LUSC cis rs13064411 0.696 rs6438159 chr3:113217341 T/C cg18753928 chr3:113234510 CCDC52 -0.51 -7.96 -0.4 2.8e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg24562669 chr7:97807699 LMTK2 -0.35 -6.2 -0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg02175503 chr12:58329896 NA 0.48 6.92 0.35 2.33e-11 Intelligence (multi-trait analysis); LUSC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.48 0.5 2.03e-22 Hip circumference adjusted for BMI; LUSC cis rs12681287 0.577 rs10481197 chr8:87546551 A/T cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs4704187 0.663 rs28448485 chr5:74425775 G/A cg03227963 chr5:74354835 NA 0.32 6.86 0.35 3.34e-11 Response to amphetamines; LUSC cis rs6998277 1.000 rs6998277 chr8:103639941 T/C cg10187029 chr8:103597600 NA 0.67 8.42 0.42 1.09e-15 Migraine; LUSC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg05738196 chr6:26577821 NA 0.53 8.32 0.41 2.23e-15 Schizophrenia; LUSC trans rs4332037 0.539 rs55773130 chr7:2070554 T/C cg10840412 chr1:235813424 GNG4 0.54 7.09 0.36 8.24e-12 Bipolar disorder; LUSC trans rs1941687 0.526 rs9959347 chr18:31316169 C/T cg27147174 chr7:100797783 AP1S1 -0.52 -8.19 -0.41 5.46e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg10862848 chr6:42927986 GNMT -0.27 -6.28 -0.33 1.04e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9287719 0.967 rs6712406 chr2:10754420 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg08677398 chr8:58056175 NA 0.51 6.68 0.34 9.95e-11 Developmental language disorder (linguistic errors); LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg07507251 chr3:52567010 NT5DC2 0.36 7.18 0.37 4.69e-12 Electroencephalogram traits; LUSC cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg11502198 chr6:26597334 ABT1 -0.56 -8.98 -0.44 1.95e-17 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg02569458 chr12:86230093 RASSF9 0.58 9.78 0.47 4.91e-20 Major depressive disorder; LUSC cis rs2580764 0.566 rs2920878 chr2:55296415 C/T cg20993754 chr2:55226987 RTN4 -0.36 -5.99 -0.31 5.34e-9 Mean platelet volume; LUSC trans rs10411161 0.702 rs10403189 chr19:52400673 A/G cg22319618 chr22:45562946 NUP50 0.5 6.02 0.31 4.63e-9 Breast cancer; LUSC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg06212747 chr3:49208901 KLHDC8B 0.54 7.13 0.36 6.21e-12 Parkinson's disease; LUSC trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg15704280 chr7:45808275 SEPT13 -0.88 -11.66 -0.54 1.34e-26 Coronary artery disease; LUSC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.75 0.54 6.37e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7267979 1.000 rs6107047 chr20:25442097 G/A cg08601574 chr20:25228251 PYGB 0.43 6.57 0.34 1.94e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg09455208 chr3:40491958 NA 0.59 11.13 0.52 1.13e-24 Renal cell carcinoma; LUSC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg11764359 chr7:65958608 NA -0.68 -11.03 -0.52 2.52e-24 Cotinine glucuronidation; LUSC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 6.11 0.32 2.75e-9 Tonsillectomy; LUSC cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg14664628 chr15:75095509 CSK -0.82 -12.54 -0.57 7.94e-30 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs6912958 0.630 rs9450726 chr6:88236728 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.71 -0.34 8.45e-11 Monocyte percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04499797 chr7:7222060 C1GALT1 -0.42 -6.75 -0.35 6.74e-11 Electrocardiographic conduction measures; LUSC cis rs875971 0.830 rs12673450 chr7:66009220 G/A cg18876405 chr7:65276391 NA 0.55 8.45 0.42 8.98e-16 Aortic root size; LUSC cis rs10740039 0.883 rs7920170 chr10:62407524 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.86 -0.35 3.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs17133449 0.718 rs7905751 chr10:4752837 A/T cg17844448 chr7:27782764 TAX1BP1 -0.38 -6.15 -0.32 2.2e-9 Major depressive disorder; LUSC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.79 0.43 8.24e-17 Height; LUSC trans rs11098499 0.697 rs28458294 chr4:120238924 T/C cg25214090 chr10:38739885 LOC399744 0.42 6.3 0.33 9.58e-10 Corneal astigmatism; LUSC cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.0 -0.48 8.83e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9581857 0.685 rs17808758 chr13:28036412 C/T cg22138327 chr13:27999177 GTF3A 0.74 7.71 0.39 1.46e-13 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC trans rs1908814 0.510 rs7819276 chr8:11755804 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -5.95 -0.31 6.72e-9 Neuroticism; LUSC cis rs9486719 0.843 rs2499787 chr6:96841762 G/C cg06623918 chr6:96969491 KIAA0776 0.76 8.63 0.43 2.51e-16 Migraine;Coronary artery disease; LUSC cis rs225245 0.782 rs225272 chr17:33969911 T/C cg05299278 chr17:33885742 SLFN14 0.31 6.77 0.35 5.81e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7098414 0.511 rs10466236 chr10:82149717 C/T cg01528321 chr10:82214614 TSPAN14 -0.59 -8.83 -0.44 5.82e-17 Post bronchodilator FEV1; LUSC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg02569458 chr12:86230093 RASSF9 -0.48 -7.59 -0.38 3.19e-13 Major depressive disorder; LUSC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg03452623 chr4:187889614 NA -0.86 -17.47 -0.69 5.36e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs8072100 0.744 rs34537623 chr17:45530203 A/G cg25173405 chr17:45401733 C17orf57 -0.37 -5.73 -0.3 2.22e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.47 -0.33 3.41e-10 High light scatter reticulocyte count; LUSC cis rs6459788 0.693 rs35146559 chr7:157238557 G/A cg06271696 chr7:157225062 NA -0.43 -8.34 -0.42 1.99e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg22496339 chr2:162101262 NA -0.52 -7.54 -0.38 4.4e-13 Intelligence (multi-trait analysis); LUSC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg22166914 chr1:53195759 ZYG11B -0.7 -12.07 -0.55 4.3e-28 Monocyte count; LUSC cis rs2425143 1.000 rs56904633 chr20:34400757 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.71 -0.3 2.56e-8 Blood protein levels; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs11785693 0.909 rs62489558 chr8:4968620 G/A cg26367366 chr8:4980734 NA 0.83 8.58 0.43 3.53e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.67 0.65 7.14e-42 Platelet count; LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.84 0.3 1.22e-8 Menopause (age at onset); LUSC cis rs9399401 0.845 rs263184 chr6:142862022 A/G cg03128060 chr6:142623767 GPR126 -0.3 -5.65 -0.3 3.42e-8 Chronic obstructive pulmonary disease; LUSC trans rs877282 1.000 rs12219807 chr10:772870 A/C cg13042288 chr15:90349979 ANPEP -0.48 -6.77 -0.35 5.86e-11 Uric acid levels; LUSC cis rs9814567 1.000 rs12637751 chr3:134266124 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6580649 0.941 rs1968071 chr12:48489357 A/G cg24011408 chr12:48396354 COL2A1 -0.44 -6.07 -0.32 3.41e-9 Lung cancer; LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg20119798 chr7:94954144 PON1 -0.45 -9.28 -0.45 2.24e-18 Paraoxonase activity; LUSC trans rs62458065 0.850 rs7804998 chr7:32461197 T/C cg00845942 chr12:64062724 DPY19L2 -0.53 -6.25 -0.32 1.28e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg18681998 chr4:17616180 MED28 0.69 11.12 0.52 1.23e-24 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.88 -0.35 2.96e-11 Lung cancer; LUSC trans rs9951602 0.512 rs56009939 chr18:76644497 T/G cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs12541635 0.902 rs59123253 chr8:107006365 C/T cg10147462 chr8:107024639 NA 0.55 9.97 0.48 1.16e-20 Age of smoking initiation; LUSC cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs1568889 1.000 rs9783281 chr11:28033786 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.59 0.46 2.08e-19 Bipolar disorder; LUSC cis rs117623576 0.941 rs67225815 chr10:32408946 C/T cg03047570 chr10:32398778 NA -0.64 -7.15 -0.36 5.37e-12 Anti-saccade response; LUSC cis rs6754311 0.593 rs313528 chr2:136445869 G/A cg07169764 chr2:136633963 MCM6 0.55 7.29 0.37 2.32e-12 Mosquito bite size; LUSC cis rs12989701 0.877 rs34854727 chr2:127855392 C/T cg08168897 chr2:127865431 BIN1 0.64 7.98 0.4 2.38e-14 Alzheimer's disease (late onset); LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 16.16 0.66 8.26e-44 Platelet count; LUSC cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg08999081 chr20:33150536 PIGU -0.51 -10.37 -0.49 5.03e-22 Glomerular filtration rate (creatinine); LUSC cis rs6940638 0.688 rs9348750 chr6:27057945 T/G cg09904177 chr6:26538194 HMGN4 -0.45 -6.63 -0.34 1.38e-10 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg05855489 chr10:104503620 C10orf26 0.57 7.43 0.38 9.15e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6982240 0.514 rs2060357 chr8:142259829 G/A cg27411547 chr8:142287226 NA -0.47 -7.97 -0.4 2.51e-14 Tonsillectomy; LUSC cis rs6977940 0.558 rs11770455 chr7:2888014 G/A cg19731401 chr7:2775893 GNA12 0.71 7.84 0.39 5.97e-14 White matter integrity; LUSC cis rs593982 0.920 rs1151500 chr11:65481166 T/C cg08755490 chr11:65554678 OVOL1 1.48 13.19 0.59 2.78e-32 Atopic dermatitis; LUSC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7829975 0.846 rs1879957 chr8:8544808 T/C cg15556689 chr8:8085844 FLJ10661 -0.62 -10.05 -0.48 6.23e-21 Mood instability; LUSC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg05347473 chr6:146136440 FBXO30 0.52 8.92 0.44 3.16e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs2455601 0.786 rs2568070 chr11:8976893 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.46 -8.06 -0.4 1.38e-14 Schizophrenia; LUSC trans rs3808502 0.549 rs1382563 chr8:11426790 C/G cg15556689 chr8:8085844 FLJ10661 0.61 9.44 0.46 6.47e-19 Neuroticism; LUSC cis rs559928 0.548 rs11231713 chr11:63931849 C/T cg05555928 chr11:63887634 MACROD1 -0.49 -6.05 -0.31 3.95e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.96 0.4 2.7e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4363385 0.510 rs11812015 chr1:153045584 G/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.23 -0.32 1.43e-9 Inflammatory skin disease; LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs4319547 0.737 rs4758646 chr12:122946507 G/A cg05707623 chr12:122985044 ZCCHC8 -0.56 -7.15 -0.36 5.65e-12 Body mass index; LUSC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg21984481 chr17:79567631 NPLOC4 -0.57 -10.79 -0.51 1.76e-23 Eye color traits; LUSC cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg24596788 chr1:163392923 NA 0.41 6.94 0.36 2.03e-11 Motion sickness; LUSC cis rs8103278 0.662 rs16980051 chr19:46345886 T/C cg20908204 chr19:46285434 DMPK -0.3 -5.68 -0.3 2.95e-8 Coronary artery disease; LUSC cis rs13385 0.769 rs13188675 chr5:139606718 G/A cg26211634 chr5:139558579 C5orf32 0.45 6.75 0.35 6.51e-11 Atrial fibrillation; LUSC cis rs950169 0.541 rs10795 chr15:85177297 G/A cg17507749 chr15:85114479 UBE2QP1 0.57 7.32 0.37 1.88e-12 Schizophrenia; LUSC cis rs11792861 0.926 rs1051474 chr9:111881856 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -7.88 -0.4 4.54e-14 Menarche (age at onset); LUSC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.89 -0.31 9.56e-9 Tonsillectomy; LUSC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg18479299 chr3:125709523 NA -0.5 -5.79 -0.3 1.66e-8 Blood pressure (smoking interaction); LUSC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -24.24 -0.8 1.33e-75 Height; LUSC cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg17261708 chr5:176794207 RGS14 0.34 6.0 0.31 4.99e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs7605827 0.897 rs2178238 chr2:15533520 C/T cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs1267303 0.675 rs1745370 chr1:46982863 C/G cg25110126 chr1:46999211 NA -0.57 -7.4 -0.38 1.11e-12 Monobrow; LUSC trans rs7937682 0.924 rs499750 chr11:111513645 T/G cg18187862 chr3:45730750 SACM1L 0.55 6.99 0.36 1.51e-11 Primary sclerosing cholangitis; LUSC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg04362960 chr10:104952993 NT5C2 0.59 9.39 0.46 9.6e-19 Reticulocyte count; LUSC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg11752832 chr7:134001865 SLC35B4 0.56 8.8 0.43 7.57e-17 Mean platelet volume; LUSC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg20203395 chr5:56204925 C5orf35 -0.46 -6.91 -0.35 2.42e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs6547741 0.844 rs55826602 chr2:27863452 A/G cg12559939 chr2:27858050 GPN1 -0.41 -6.32 -0.33 8.49e-10 Oral cavity cancer; LUSC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg06481639 chr22:41940642 POLR3H -0.56 -6.23 -0.32 1.4e-9 Vitiligo; LUSC cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg01557791 chr16:72042693 DHODH 0.55 8.23 0.41 4.15e-15 Fibrinogen levels; LUSC cis rs189798 0.807 rs12785 chr8:8994936 A/T cg06636001 chr8:8085503 FLJ10661 0.51 6.8 0.35 4.82e-11 Myopia (pathological); LUSC cis rs61931739 0.500 rs6488221 chr12:34525671 A/G cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs9815354 0.812 rs74947509 chr3:42006323 T/C cg03022575 chr3:42003672 ULK4 0.79 8.31 0.41 2.48e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs10050311 0.746 rs72665791 chr4:87678787 C/T cg10685359 chr4:87814065 C4orf36 -0.43 -5.66 -0.3 3.19e-8 Insulin-related traits; LUSC trans rs61931739 0.853 rs11053002 chr12:34083499 T/C cg24313572 chr1:56050060 NA 0.29 5.97 0.31 5.9e-9 Morning vs. evening chronotype; LUSC cis rs3858526 0.834 rs7113548 chr11:5989293 G/A cg13902645 chr11:5959945 NA -0.6 -8.26 -0.41 3.39e-15 DNA methylation (variation); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06074314 chr2:70475575 TIA1 0.47 7.02 0.36 1.28e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.87 0.35 3.08e-11 Multiple sclerosis; LUSC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs72781680 1.000 rs72796337 chr2:24142957 G/A cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs250677 0.559 rs17109198 chr5:148369712 C/T cg18129178 chr5:148520854 ABLIM3 -0.5 -7.25 -0.37 3e-12 Breast cancer; LUSC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.07 -0.32 3.51e-9 Alzheimer's disease (late onset); LUSC cis rs9790314 1.000 rs1382426 chr3:161045933 G/A cg04691961 chr3:161091175 C3orf57 -0.34 -5.89 -0.31 9.47e-9 Morning vs. evening chronotype; LUSC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg11608241 chr8:8085544 FLJ10661 0.4 5.87 0.31 1.04e-8 Mood instability; LUSC trans rs853679 0.882 rs2743555 chr6:28241081 G/A cg01620082 chr3:125678407 NA -0.51 -6.04 -0.31 4.06e-9 Depression; LUSC cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg08754478 chr10:133766260 PPP2R2D -0.63 -8.13 -0.41 8.49e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2273669 0.667 rs12215344 chr6:109329641 A/C cg05315195 chr6:109294784 ARMC2 -0.53 -5.9 -0.31 8.99e-9 Prostate cancer; LUSC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg23205692 chr1:25664452 TMEM50A 0.43 6.54 0.34 2.25e-10 Plateletcrit;Mean corpuscular volume; LUSC trans rs1973993 0.689 rs17131755 chr1:96886167 G/A cg10631902 chr5:14652156 NA -0.54 -8.07 -0.4 1.29e-14 Weight; LUSC cis rs9815354 0.723 rs79741604 chr3:41947321 C/T cg03022575 chr3:42003672 ULK4 0.81 8.49 0.42 6.81e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg06618935 chr21:46677482 NA -0.36 -6.89 -0.35 2.77e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.57 -9.21 -0.45 3.59e-18 Personality dimensions; LUSC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg05084668 chr3:125655381 ALG1L -0.5 -6.93 -0.35 2.15e-11 Blood pressure (smoking interaction); LUSC cis rs6545883 0.929 rs3732171 chr2:61749690 C/T cg15711740 chr2:61764176 XPO1 -0.52 -8.24 -0.41 3.95e-15 Tuberculosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17818798 chr19:14228473 PRKACA -0.51 -6.84 -0.35 3.83e-11 Bipolar disorder and schizophrenia; LUSC cis rs6681460 0.674 rs7543607 chr1:67012592 G/T cg02459107 chr1:67143332 SGIP1 0.37 6.15 0.32 2.24e-9 Presence of antiphospholipid antibodies; LUSC cis rs9902453 0.765 rs2729440 chr17:28106874 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.68 -0.54 1.16e-26 Coffee consumption (cups per day); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12044295 chr8:56686133 TMEM68;TGS1 0.73 6.1 0.32 2.91e-9 Cognitive performance; LUSC cis rs7923609 1.000 rs1935 chr10:64927823 C/G cg01631684 chr10:65280961 REEP3 -0.41 -6.47 -0.33 3.49e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7617480 0.648 rs4974083 chr3:49000626 A/G cg07636037 chr3:49044803 WDR6 0.9 11.64 0.54 1.69e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs8060686 0.641 rs8064114 chr16:68240185 G/A cg27539214 chr16:67997921 SLC12A4 -0.51 -6.76 -0.35 6.3e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg26380479 chr7:97908229 NA -0.29 -6.39 -0.33 5.55e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs4450131 0.522 rs11245328 chr10:126358413 G/A cg20435097 chr10:126320824 FAM53B 0.24 6.05 0.31 3.87e-9 White blood cell count (basophil); LUSC cis rs2354432 0.607 rs10900350 chr1:146828017 T/G cg25205988 chr1:146714368 CHD1L 0.93 8.78 0.43 8.83e-17 Mitochondrial DNA levels; LUSC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg07424592 chr7:64974309 NA 0.6 5.82 0.3 1.41e-8 Diabetic kidney disease; LUSC cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg09184832 chr6:79620586 NA -0.44 -7.2 -0.37 4.13e-12 Intelligence (multi-trait analysis); LUSC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg15691649 chr6:25882328 NA -0.41 -5.95 -0.31 6.66e-9 Intelligence (multi-trait analysis); LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg11965913 chr1:205819406 PM20D1 0.81 15.39 0.64 9.35e-41 Menarche (age at onset); LUSC cis rs722599 0.748 rs741096 chr14:75351487 A/G cg08847533 chr14:75593920 NEK9 -0.48 -6.88 -0.35 3e-11 IgG glycosylation; LUSC trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21659725 chr3:3221576 CRBN -0.58 -8.2 -0.41 5.33e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs12980942 0.935 rs1865052 chr19:41824467 G/A cg25627403 chr19:41769009 HNRNPUL1 0.57 6.15 0.32 2.17e-9 Coronary artery disease; LUSC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg11861562 chr11:117069780 TAGLN 0.41 7.39 0.37 1.23e-12 Blood protein levels; LUSC cis rs6964587 1.000 rs58965837 chr7:91585258 T/A cg01689657 chr7:91764605 CYP51A1 0.32 5.95 0.31 6.89e-9 Breast cancer; LUSC cis rs9815354 0.680 rs73073274 chr3:42022810 T/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs8038465 0.592 rs58443257 chr15:73930707 A/T cg15420318 chr15:73925796 NPTN 0.57 9.74 0.47 6.56e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Melanoma; LUSC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.99 -0.44 1.85e-17 Electroencephalogram traits; LUSC cis rs7954584 0.635 rs11043242 chr12:122356293 G/C cg22618164 chr12:122356400 WDR66 0.6 8.76 0.43 9.78e-17 Mean corpuscular volume; LUSC cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg10523679 chr1:76189770 ACADM -0.53 -7.87 -0.4 5.03e-14 Daytime sleep phenotypes; LUSC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.39 5.99 0.31 5.3e-9 Platelet count; LUSC cis rs4595586 0.545 rs12815047 chr12:39380901 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs8060686 0.565 rs4359427 chr16:68202747 C/T cg27539214 chr16:67997921 SLC12A4 -0.5 -6.62 -0.34 1.4e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs72781680 1.000 rs72781680 chr2:24238928 C/T cg20701182 chr2:24300061 SF3B14 0.75 7.54 0.38 4.62e-13 Lymphocyte counts; LUSC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.5 0.53 5.42e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs7615952 0.546 rs11717632 chr3:125321130 G/C cg07211511 chr3:129823064 LOC729375 -0.55 -6.07 -0.32 3.38e-9 Blood pressure (smoking interaction); LUSC cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg05973401 chr12:123451056 ABCB9 0.54 6.73 0.35 7.52e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg12311346 chr5:56204834 C5orf35 -0.62 -9.52 -0.46 3.7e-19 Coronary artery disease; LUSC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg10018233 chr7:150070692 REPIN1 0.34 6.01 0.31 4.93e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg05294307 chr14:35346193 BAZ1A -0.61 -7.4 -0.38 1.15e-12 Psoriasis; LUSC cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg06627557 chr7:32535165 LSM5;AVL9 1.08 21.02 0.75 4.3e-63 Cognitive ability; LUSC cis rs12971120 0.838 rs747176 chr18:72154931 G/A cg25817165 chr18:72167213 CNDP2 -0.72 -9.74 -0.47 6.57e-20 Refractive error; LUSC cis rs12956009 0.583 rs11663646 chr18:44862895 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -6.14 -0.32 2.29e-9 Educational attainment (years of education); LUSC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg08270630 chr22:50330655 NA -0.41 -5.92 -0.31 7.82e-9 Schizophrenia; LUSC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg07701084 chr6:150067640 NUP43 0.58 8.86 0.44 4.78e-17 Lung cancer; LUSC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg06022373 chr22:39101656 GTPBP1 0.85 14.43 0.62 4.86e-37 Menopause (age at onset); LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg05368731 chr17:41323189 NBR1 0.92 15.84 0.66 1.49e-42 Menopause (age at onset); LUSC cis rs72781680 0.898 rs72796396 chr2:24178154 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.2 0.32 1.71e-9 Lymphocyte counts; LUSC cis rs6424115 1.000 rs12116511 chr1:24162662 A/G cg10978503 chr1:24200527 CNR2 -0.49 -11.45 -0.53 7.89e-26 Immature fraction of reticulocytes; LUSC cis rs7830933 0.955 rs1550280 chr8:23601830 C/T cg04349084 chr8:23602677 NA 0.38 6.06 0.31 3.72e-9 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; LUSC trans rs11098499 0.697 rs11941899 chr4:120382758 C/A cg25214090 chr10:38739885 LOC399744 0.57 8.42 0.42 1.14e-15 Corneal astigmatism; LUSC cis rs738322 0.555 rs731821 chr22:38559448 C/A cg25457927 chr22:38595422 NA -0.4 -7.91 -0.4 3.84e-14 Cutaneous nevi; LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg13628971 chr7:2884303 GNA12 0.49 7.21 0.37 3.68e-12 Height; LUSC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg22963979 chr7:1858916 MAD1L1 -0.55 -8.23 -0.41 4.37e-15 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.806 rs12449170 chr16:75463012 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.46e-10 Body mass index; LUSC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg13628971 chr7:2884303 GNA12 0.45 6.51 0.34 2.78e-10 Height; LUSC cis rs3020736 0.500 rs28791586 chr22:42500483 A/G cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs7084921 0.608 rs11592689 chr10:101865516 A/T cg11888571 chr10:102027403 CWF19L1 -0.45 -6.23 -0.32 1.4e-9 Bone mineral density; LUSC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg09998033 chr7:158218633 PTPRN2 -0.52 -8.34 -0.42 1.98e-15 Obesity-related traits; LUSC cis rs922692 0.710 rs1994016 chr15:79080234 C/T cg00540400 chr15:79124168 NA -0.35 -6.09 -0.32 3.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg13902645 chr11:5959945 NA 0.66 10.1 0.48 4.18e-21 DNA methylation (variation); LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg12016809 chr21:47604291 C21orf56 0.41 6.24 0.32 1.36e-9 Testicular germ cell tumor; LUSC cis rs72781680 0.821 rs111571980 chr2:24201695 C/G cg08917208 chr2:24149416 ATAD2B 0.6 6.9 0.35 2.66e-11 Lymphocyte counts; LUSC cis rs34375054 0.738 rs3751181 chr12:125626535 A/G cg09839279 chr12:125627357 AACS -0.35 -6.64 -0.34 1.26e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6722750 0.933 rs12999721 chr2:64407710 C/T cg22352474 chr2:64371530 PELI1 0.51 7.63 0.39 2.54e-13 Neuroticism; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.84 -0.44 5.44e-17 Monocyte count; LUSC cis rs738322 0.511 rs5756947 chr22:38573230 G/A cg25457927 chr22:38595422 NA -0.37 -6.93 -0.35 2.13e-11 Cutaneous nevi; LUSC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg03433033 chr1:76189801 ACADM 0.83 14.99 0.63 3.28e-39 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs1908814 0.516 rs4841641 chr8:11798227 G/A cg08975724 chr8:8085496 FLJ10661 0.45 6.53 0.34 2.41e-10 Neuroticism; LUSC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg09035930 chr12:129282057 SLC15A4 0.73 15.97 0.66 4.51e-43 Systemic lupus erythematosus; LUSC cis rs34421088 0.560 rs2245357 chr8:11399484 A/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.91 -0.31 8.25e-9 Neuroticism; LUSC cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg12011299 chr4:100065546 ADH4 0.74 12.2 0.56 1.45e-28 Alcohol dependence; LUSC cis rs3770081 1.000 rs3770081 chr2:86280925 G/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.07 -6.9 -0.35 2.62e-11 Facial emotion recognition (sad faces); LUSC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg22862634 chr11:62369728 EML3;MTA2 0.59 9.3 0.45 1.83e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22688104 chr4:47916759 NFXL1 -0.44 -6.53 -0.34 2.5e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg15744005 chr10:104629667 AS3MT -0.28 -5.93 -0.31 7.59e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs2729385 1.000 rs2729385 chr11:57262993 C/T cg02565297 chr12:133144810 FBRSL1 -0.42 -6.05 -0.31 3.9e-9 Interleukin-18 levels; LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg24675658 chr1:53192096 ZYG11B -0.7 -11.53 -0.53 3.91e-26 Monocyte count; LUSC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.84 -0.39 6.1e-14 Blood metabolite levels; LUSC cis rs4363385 0.530 rs6663448 chr1:152894627 C/T cg00922841 chr1:152955080 SPRR1A -0.36 -5.99 -0.31 5.47e-9 Inflammatory skin disease; LUSC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg12639453 chr1:2035780 PRKCZ -0.3 -6.3 -0.33 9.13e-10 Height; LUSC cis rs9875589 0.509 rs7614591 chr3:14061118 A/T cg19554555 chr3:13937349 NA -0.38 -5.71 -0.3 2.44e-8 Ovarian reserve; LUSC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg18904891 chr8:8559673 CLDN23 0.38 5.73 0.3 2.27e-8 Joint mobility (Beighton score); LUSC cis rs7264396 0.561 rs6060753 chr20:34598430 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.61 -0.34 1.53e-10 Total cholesterol levels; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg27535305 chr1:53392650 SCP2 -0.49 -9.55 -0.46 2.99e-19 Monocyte count; LUSC cis rs478304 0.651 rs4930313 chr11:65500428 C/T cg05805236 chr11:65401703 PCNXL3 -0.57 -9.25 -0.45 2.79e-18 Acne (severe); LUSC cis rs2859741 0.528 rs2359647 chr1:37483054 A/T cg09363841 chr1:37513479 NA -0.39 -7.47 -0.38 6.88e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg00509249 chr6:109615579 CCDC162 0.32 5.87 0.31 1.05e-8 Reticulocyte fraction of red cells; LUSC cis rs4566357 0.615 rs12621808 chr2:227909522 A/C cg11843606 chr2:227700838 RHBDD1 -0.55 -8.39 -0.42 1.42e-15 Coronary artery disease; LUSC cis rs2439831 0.867 rs2447208 chr15:43933895 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.36 0.37 1.41e-12 Lung cancer in ever smokers; LUSC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg11062466 chr8:58055876 NA 0.51 6.9 0.35 2.67e-11 Developmental language disorder (linguistic errors); LUSC cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg14582100 chr15:45693742 SPATA5L1 0.59 10.64 0.5 5.61e-23 Homoarginine levels; LUSC cis rs11122272 0.735 rs2790876 chr1:231536033 C/T cg06096015 chr1:231504339 EGLN1 0.57 10.04 0.48 6.89e-21 Hemoglobin concentration; LUSC cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg04455712 chr21:45112962 RRP1B -0.44 -8.04 -0.4 1.61e-14 Mean corpuscular volume; LUSC cis rs7119038 0.818 rs4936444 chr11:118743338 A/G cg19308663 chr11:118741387 NA -0.33 -5.8 -0.3 1.57e-8 Sjögren's syndrome; LUSC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg15556689 chr8:8085844 FLJ10661 0.69 11.24 0.52 4.36e-25 Mood instability; LUSC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg15691649 chr6:25882328 NA -0.37 -6.14 -0.32 2.31e-9 Blood metabolite levels; LUSC cis rs2370759 0.945 rs10508773 chr10:32575444 C/T cg01819863 chr10:32635814 EPC1 1.08 13.44 0.59 3.21e-33 Sexual dysfunction (female); LUSC cis rs7246657 0.882 rs10422667 chr19:37937876 T/C cg23950597 chr19:37808831 NA -0.64 -7.64 -0.39 2.31e-13 Coronary artery calcification; LUSC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg03233332 chr7:66118400 NA -0.42 -6.09 -0.32 3.05e-9 Aortic root size; LUSC cis rs2932538 0.961 rs2932529 chr1:113193364 G/A cg22162597 chr1:113214053 CAPZA1 -0.7 -9.88 -0.48 2.33e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg05082376 chr22:42548792 NA -0.45 -7.19 -0.37 4.24e-12 Schizophrenia; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg11239145 chr4:26320844 RBPJ 0.52 6.61 0.34 1.5e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs791888 0.698 rs7893652 chr10:89431060 A/G cg13926569 chr10:89418898 PAPSS2 -0.36 -7.26 -0.37 2.74e-12 Magnesium levels; LUSC cis rs2050392 0.517 rs603072 chr10:30755778 C/T cg25182066 chr10:30743637 MAP3K8 0.45 6.63 0.34 1.33e-10 Inflammatory bowel disease; LUSC cis rs2795502 1.000 rs2744090 chr10:43339614 G/C cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC cis rs7192380 0.965 rs9938213 chr16:69640590 T/C cg26679644 chr16:69762563 NA 0.35 6.2 0.32 1.7e-9 Sjögren's syndrome; LUSC cis rs11714574 0.557 rs6787467 chr3:58377888 G/A cg23715586 chr3:58305044 RPP14 0.35 6.31 0.33 9.08e-10 Response to abacavir-containing treatment in HIV-1 infection (virologic failure); LUSC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg08048268 chr3:133502702 NA 0.29 5.66 0.3 3.35e-8 Iron status biomarkers; LUSC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg12257692 chr3:49977190 RBM6 -0.26 -7.25 -0.37 2.87e-12 Intelligence (multi-trait analysis); LUSC trans rs11148252 0.574 rs9536247 chr13:53279542 T/C cg18335740 chr13:41363409 SLC25A15 0.79 14.99 0.63 3.41e-39 Lewy body disease; LUSC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg19920283 chr7:105172520 RINT1 0.58 6.28 0.32 1.08e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg20283391 chr11:68216788 NA -0.58 -8.24 -0.41 4.1e-15 Total body bone mineral density; LUSC cis rs7131987 0.903 rs7302129 chr12:29415280 A/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.89 -0.35 2.85e-11 QT interval; LUSC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.83 0.43 6.17e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs7267979 0.773 rs6132821 chr20:25226192 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.68 12.94 0.58 2.53e-31 Liver enzyme levels (alkaline phosphatase); LUSC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg02038168 chr22:39784481 NA -0.41 -6.11 -0.32 2.83e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs12464559 0.649 rs7557801 chr2:152586658 G/A cg01189475 chr2:152685088 ARL5A 0.63 5.65 0.3 3.52e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs7584330 0.504 rs11883500 chr2:238434434 C/T cg14458575 chr2:238380390 NA 0.44 5.67 0.3 3.16e-8 Prostate cancer; LUSC cis rs2204008 0.837 rs12370891 chr12:37984531 A/G cg13010199 chr12:38710504 ALG10B 0.7 10.92 0.51 5.92e-24 Bladder cancer; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg14893161 chr1:205819251 PM20D1 0.81 16.1 0.66 1.5e-43 Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04522604 chr5:111093927 C5orf13 0.53 7.69 0.39 1.7e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8005677 0.962 rs8003934 chr14:23401142 A/G cg00579484 chr14:23475993 C14orf93 0.39 5.74 0.3 2.12e-8 Cognitive ability (multi-trait analysis); LUSC cis rs600231 0.623 rs587080 chr11:65253800 A/C cg21890820 chr11:65308645 LTBP3 0.5 7.36 0.37 1.47e-12 Bone mineral density; LUSC cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg21535247 chr6:8435926 SLC35B3 0.6 9.26 0.45 2.49e-18 Motion sickness; LUSC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg22823121 chr1:150693482 HORMAD1 -0.5 -7.04 -0.36 1.1e-11 Blood protein levels; LUSC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs2276314 0.947 rs16967319 chr18:33573525 A/G cg19628046 chr18:33552617 C18orf21 0.49 5.91 0.31 8.33e-9 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs2262909 0.962 rs390730 chr19:22233509 C/A cg17074339 chr11:11642133 GALNTL4 -0.46 -7.07 -0.36 9.1e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg03929089 chr4:120376271 NA -0.83 -11.43 -0.53 9e-26 Height; LUSC cis rs6495122 0.501 rs6495151 chr15:75385990 A/G cg09165964 chr15:75287851 SCAMP5 -0.47 -6.85 -0.35 3.54e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg06022373 chr22:39101656 GTPBP1 -0.76 -11.35 -0.53 1.84e-25 Menopause (age at onset); LUSC cis rs17401966 1.000 rs1339458 chr1:10328338 C/T cg19773385 chr1:10388646 KIF1B -0.54 -8.39 -0.42 1.42e-15 Hepatocellular carcinoma; LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg07157834 chr1:205819609 PM20D1 0.44 6.18 0.32 1.89e-9 Menarche (age at onset); LUSC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg06713675 chr4:122721982 EXOSC9 -0.66 -11.43 -0.53 9.68e-26 Type 2 diabetes; LUSC cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.17e-22 Bladder cancer; LUSC cis rs950776 0.616 rs647041 chr15:78880481 T/C cg06917634 chr15:78832804 PSMA4 -0.75 -13.04 -0.58 1.03e-31 Sudden cardiac arrest; LUSC cis rs10752881 0.809 rs3738829 chr1:183113862 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC cis rs2346177 0.846 rs62138876 chr2:46650672 C/A cg26688816 chr2:46740690 ATP6V1E2 -0.54 -8.47 -0.42 7.93e-16 HDL cholesterol; LUSC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg23758822 chr17:41437982 NA 1.02 20.24 0.74 5.16e-60 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14140629 chr6:127587906 RNF146 -0.45 -6.66 -0.34 1.13e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs317865 0.737 rs73234642 chr4:16186730 G/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.62 6.0 0.31 5.04e-9 Kidney disease (early stage) in type 1 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17602823 chr1:28586543 SESN2 -0.49 -6.52 -0.34 2.56e-10 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg05347473 chr6:146136440 FBXO30 -0.57 -9.83 -0.47 3.34e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg23188684 chr11:67383651 NA 0.35 6.27 0.32 1.1e-9 Mean corpuscular volume; LUSC cis rs9929218 0.953 rs2902323 chr16:68736292 C/T cg02972257 chr16:68554789 NA 0.45 5.79 0.3 1.6e-8 Colorectal cancer; LUSC cis rs9462027 0.539 rs9469883 chr6:34758627 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.02 -0.31 4.55e-9 Systemic lupus erythematosus; LUSC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg03806693 chr22:41940476 POLR3H 0.99 13.72 0.6 2.7200000000000002e-34 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg12432903 chr7:1882776 MAD1L1 -0.51 -8.58 -0.42 3.72e-16 Bipolar disorder and schizophrenia; LUSC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg27432699 chr2:27873401 GPN1 -0.55 -8.24 -0.41 3.98e-15 Total body bone mineral density; LUSC cis rs7264396 0.563 rs17093093 chr20:34380925 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -7.4 -0.38 1.08e-12 Total cholesterol levels; LUSC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg19592336 chr6:28129416 ZNF389 0.45 5.85 0.3 1.16e-8 Depression; LUSC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg22467129 chr15:76604101 ETFA -0.44 -6.97 -0.36 1.67e-11 Blood metabolite levels; LUSC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -8.07 -0.4 1.29e-14 Mean platelet volume; LUSC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg00509249 chr6:109615579 CCDC162 -0.35 -6.29 -0.33 1.01e-9 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; LUSC cis rs7249142 0.549 rs62135499 chr19:19294237 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.36 -5.78 -0.3 1.68e-8 IgG glycosylation; LUSC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg09796270 chr17:17721594 SREBF1 0.4 6.93 0.35 2.23e-11 Total body bone mineral density; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.28 -0.56 7.46e-29 Alzheimer's disease; LUSC cis rs3733418 0.929 rs17623445 chr4:165894658 C/T cg08992305 chr4:165878219 TRIM61;C4orf39 -0.47 -5.75 -0.3 2.02e-8 Obesity-related traits; LUSC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs13394619 0.775 rs10165819 chr2:11722102 A/T cg07314298 chr2:11723111 GREB1 -0.54 -9.4 -0.46 8.73e-19 Endometriosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15487600 chr1:155113158 DPM3 -0.47 -6.2 -0.32 1.71e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.32 0.56 5.14e-29 Prudent dietary pattern; LUSC cis rs1790761 0.505 rs7927657 chr11:67346988 T/C cg24690094 chr11:67383802 NA -0.3 -5.71 -0.3 2.46e-8 Mean corpuscular volume; LUSC cis rs71403859 0.667 rs12149264 chr16:71720921 T/G cg08717414 chr16:71523259 ZNF19 -0.64 -7.31 -0.37 2.02e-12 Post bronchodilator FEV1; LUSC trans rs11935423 0.778 rs1800804 chr4:100495817 T/C cg02164153 chr5:172068145 NEURL1B -0.47 -6.1 -0.32 3e-9 Gut microbiome composition (summer); LUSC trans rs12439619 0.693 rs7165536 chr15:82566084 T/A cg04831495 chr15:85060580 GOLGA6L5 -0.45 -6.12 -0.32 2.56e-9 Intelligence (multi-trait analysis); LUSC trans rs3733585 0.578 rs6837224 chr4:9955255 G/T cg26043149 chr18:55253948 FECH -0.45 -6.99 -0.36 1.49e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs5769707 0.681 rs2071902 chr22:50034538 G/C cg10356904 chr22:49881777 NA -0.29 -5.8 -0.3 1.55e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg11062466 chr8:58055876 NA 0.77 8.65 0.43 2.16e-16 Developmental language disorder (linguistic errors); LUSC cis rs72717009 0.825 rs12722986 chr1:161465420 A/G cg23840854 chr1:161414152 NA -0.89 -11.0 -0.52 3.1e-24 Rheumatoid arthritis; LUSC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22590775 chr19:49891494 CCDC155 0.56 7.32 0.37 1.92e-12 Multiple sclerosis; LUSC trans rs79976124 0.877 rs79507557 chr6:66640908 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.86 0.44 4.84e-17 Type 2 diabetes; LUSC trans rs9650657 0.504 rs6601566 chr8:11042974 G/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.75 -0.35 6.4e-11 Neuroticism; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.68 0.65 6.64e-42 Platelet count; LUSC cis rs4285028 0.747 rs12634032 chr3:121524575 G/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.29 -0.45 2e-18 Multiple sclerosis; LUSC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.41 -0.33 5.08e-10 Extrinsic epigenetic age acceleration; LUSC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg14004847 chr7:1930337 MAD1L1 -0.54 -8.15 -0.41 7.17e-15 Bipolar disorder and schizophrenia; LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.79 -0.57 9.23e-31 Platelet count; LUSC cis rs6496044 0.568 rs12898783 chr15:86066100 G/C cg13263323 chr15:86062960 AKAP13 -0.38 -6.27 -0.32 1.12e-9 Interstitial lung disease; LUSC cis rs11122272 0.735 rs2491416 chr1:231547335 T/C cg06096015 chr1:231504339 EGLN1 -0.53 -9.26 -0.45 2.5e-18 Hemoglobin concentration; LUSC cis rs6964587 1.000 rs13239875 chr7:91716104 G/A cg01689657 chr7:91764605 CYP51A1 0.31 5.65 0.3 3.48e-8 Breast cancer; LUSC cis rs6940638 0.688 rs6921388 chr6:27080205 A/G cg05738196 chr6:26577821 NA -0.48 -6.87 -0.35 3.21e-11 Intelligence (multi-trait analysis); LUSC cis rs7809950 1.000 rs2520268 chr7:107191161 T/A cg23024343 chr7:107201750 COG5 -0.58 -9.07 -0.44 1.01e-17 Coronary artery disease; LUSC cis rs748404 0.660 rs2444251 chr15:43788595 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs75229567 0.618 rs11495622 chr12:70161286 G/A cg10114359 chr12:70132523 RAB3IP 1.34 12.39 0.56 3.01e-29 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs4242434 0.889 rs11783129 chr8:22453426 G/A cg03733263 chr8:22462867 KIAA1967 0.98 17.34 0.69 1.72e-48 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg00166722 chr3:10149974 C3orf24 0.6 8.36 0.42 1.72e-15 Alzheimer's disease; LUSC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg15839431 chr19:19639596 YJEFN3 -0.43 -5.95 -0.31 6.64e-9 Tonsillectomy; LUSC cis rs16866061 1.000 rs72972378 chr2:225372562 A/G cg12698349 chr2:225449008 CUL3 0.86 13.86 0.6 8.21e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs9929218 1.000 rs9928847 chr16:68797893 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.53 -0.53 4.11e-26 Colorectal cancer; LUSC cis rs6723108 0.616 rs6752634 chr2:135407355 G/A cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Type 2 diabetes; LUSC cis rs9527 0.662 rs743575 chr10:104594906 T/G cg05855489 chr10:104503620 C10orf26 0.63 9.17 0.45 4.86e-18 Arsenic metabolism; LUSC cis rs921665 0.831 rs7578217 chr2:3175376 A/G cg02624386 chr2:3182749 NA -0.58 -6.76 -0.35 6.19e-11 World class endurance athleticism; LUSC cis rs7085104 0.700 rs3740397 chr10:104592675 G/C cg05855489 chr10:104503620 C10orf26 0.65 9.75 0.47 6.17e-20 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 6.8 0.35 4.94e-11 Rheumatoid arthritis; LUSC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg23711669 chr6:146136114 FBXO30 0.87 16.1 0.66 1.46e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg18512352 chr11:47633146 NA 0.46 9.23 0.45 3.18e-18 Subjective well-being; LUSC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg08219700 chr8:58056026 NA 0.51 5.9 0.31 8.96e-9 Developmental language disorder (linguistic errors); LUSC cis rs1595825 0.891 rs16866980 chr2:198513009 A/C cg00982548 chr2:198649783 BOLL -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis; LUSC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg00999904 chr2:3704751 ALLC -0.47 -7.34 -0.37 1.67e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs3858526 0.834 rs7939099 chr11:5995792 G/A cg02574844 chr11:5959923 NA -0.42 -5.89 -0.31 9.19e-9 DNA methylation (variation); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24796471 chr19:6737389 GPR108 0.47 6.26 0.32 1.19e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72781680 1.000 rs72796358 chr2:24160132 T/A cg20701182 chr2:24300061 SF3B14 0.57 5.87 0.31 1.04e-8 Lymphocyte counts; LUSC cis rs12760731 0.517 rs34437852 chr1:178228721 T/C cg00404053 chr1:178313656 RASAL2 0.69 6.96 0.36 1.78e-11 Obesity-related traits; LUSC trans rs12887734 0.569 rs66953418 chr14:104271470 G/A cg16487237 chr3:137487248 NA 0.36 6.02 0.31 4.69e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg21433313 chr16:3507492 NAT15 0.45 5.94 0.31 7.02e-9 Body mass index (adult); LUSC cis rs10191773 0.535 rs12477879 chr2:112969865 C/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.72 7.98 0.4 2.36e-14 Yeast infection; LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.92 -0.31 7.84e-9 Platelet count; LUSC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg09267113 chr7:98030324 BAIAP2L1 0.41 6.14 0.32 2.35e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.7 -0.34 9.12e-11 Alzheimer's disease (late onset); LUSC trans rs208520 1.000 rs208520 chr6:66952828 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.26 -0.56 8.59e-29 Exhaled nitric oxide output; LUSC cis rs2742417 1.000 rs2245705 chr3:45749722 A/G cg09608765 chr3:45636137 LIMD1 -0.35 -7.09 -0.36 7.95e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9549367 0.789 rs3764124 chr13:113897320 C/T cg18105134 chr13:113819100 PROZ -0.69 -10.47 -0.5 2.25e-22 Platelet distribution width; LUSC cis rs8099014 1.000 rs9946396 chr18:56107163 G/A cg12907477 chr18:56117327 MIR122 0.39 6.18 0.32 1.84e-9 Platelet count; LUSC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg09877947 chr5:131593287 PDLIM4 -0.36 -5.78 -0.3 1.71e-8 Breast cancer;Mosquito bite size; LUSC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg24531977 chr5:56204891 C5orf35 0.84 13.55 0.6 1.27e-33 Initial pursuit acceleration; LUSC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg20203395 chr5:56204925 C5orf35 0.46 6.82 0.35 4.38e-11 Coronary artery disease; LUSC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg07636037 chr3:49044803 WDR6 0.46 6.64 0.34 1.28e-10 Resting heart rate; LUSC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg23262073 chr20:60523788 NA -0.43 -6.16 -0.32 2.08e-9 Body mass index; LUSC trans rs9291683 0.538 rs11727199 chr4:10036190 C/T cg26043149 chr18:55253948 FECH 0.49 7.3 0.37 2.09e-12 Bone mineral density; LUSC cis rs10504073 0.584 rs62507210 chr8:49946601 C/T cg00325661 chr8:49890786 NA 0.69 11.09 0.52 1.52e-24 Blood metabolite ratios; LUSC cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg17063962 chr7:91808500 NA 0.59 9.17 0.45 4.98e-18 Breast cancer; LUSC cis rs7516138 1.000 rs4240896 chr1:9713500 A/G cg26573321 chr1:9711663 PIK3CD -0.63 -11.02 -0.52 2.66e-24 Monocyte count; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg05374718 chr1:112282133 C1orf183 0.44 6.31 0.33 8.91e-10 Mosquito bite size; LUSC cis rs7666738 0.546 rs9993299 chr4:98815976 G/A cg17366294 chr4:99064904 C4orf37 0.57 8.73 0.43 1.22e-16 Colonoscopy-negative controls vs population controls; LUSC trans rs72792513 1.000 rs56113869 chr2:22909457 G/A cg05844895 chr16:88969569 CBFA2T3 0.53 6.19 0.32 1.77e-9 Hepatitis B; LUSC cis rs2180341 0.597 rs11154397 chr6:127646649 G/C cg24812749 chr6:127587940 RNF146 0.64 9.56 0.46 2.76e-19 Breast cancer; LUSC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg00149659 chr3:10157352 C3orf10 0.64 9.07 0.44 1.04e-17 Alzheimer's disease; LUSC cis rs4820294 1.000 rs62236665 chr22:38059847 C/A cg21798802 chr22:38057573 PDXP 0.48 10.53 0.5 1.4e-22 Fat distribution (HIV); LUSC trans rs10506458 0.915 rs60094497 chr12:63394838 T/G cg22491629 chr6:157744540 C6orf35 -0.9 -10.83 -0.51 1.29e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg25173405 chr17:45401733 C17orf57 -0.39 -6.19 -0.32 1.74e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs7937682 0.883 rs1612013 chr11:111456293 A/G cg18187862 chr3:45730750 SACM1L 0.53 6.9 0.35 2.6e-11 Primary sclerosing cholangitis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg24268822 chr3:49059985 NDUFAF3 0.46 6.16 0.32 2.04e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs2204008 0.805 rs10881112 chr12:37956611 G/A cg06521331 chr12:34319734 NA 0.39 6.12 0.32 2.67e-9 Bladder cancer; LUSC cis rs1256061 0.603 rs1256041 chr14:64738029 A/G cg23250157 chr14:64679961 SYNE2 0.32 5.7 0.3 2.68e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs2147959 0.882 rs4653552 chr1:228628138 A/G cg18477163 chr1:228402036 OBSCN -0.42 -5.86 -0.31 1.08e-8 Adult asthma; LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.12 0.36 6.47e-12 Bipolar disorder; LUSC cis rs6545883 0.929 rs2593625 chr2:61668769 C/T cg15711740 chr2:61764176 XPO1 -0.46 -7.12 -0.36 6.47e-12 Tuberculosis; LUSC cis rs1371867 0.839 rs1788186 chr8:101335686 T/C cg06636551 chr8:101224915 SPAG1 -0.38 -7.13 -0.36 6.31e-12 Atrioventricular conduction; LUSC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.64 0.47 1.49e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12620999 0.941 rs4663701 chr2:238036884 C/T cg23555395 chr2:238036564 NA -0.51 -8.73 -0.43 1.28e-16 Systemic lupus erythematosus; LUSC cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg22681709 chr2:178499509 PDE11A -0.48 -7.38 -0.37 1.26e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs61931739 0.534 rs10844791 chr12:34211659 C/T cg06521331 chr12:34319734 NA -0.46 -7.59 -0.38 3.27e-13 Morning vs. evening chronotype; LUSC trans rs800082 0.934 rs6788831 chr3:144290498 G/T cg24215973 chr2:240111563 HDAC4 -0.48 -7.36 -0.37 1.43e-12 Smoking behavior; LUSC cis rs73200209 0.744 rs61937387 chr12:116707971 A/T cg01776926 chr12:116560359 MED13L -0.49 -5.83 -0.3 1.29e-8 Total body bone mineral density; LUSC cis rs3764021 0.870 rs7956831 chr12:9889157 A/G cg20894963 chr12:9885564 CLECL1 -0.33 -6.82 -0.35 4.39e-11 Type 1 diabetes; LUSC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg00864171 chr11:67383662 NA 0.42 7.8 0.39 7.89e-14 Mean corpuscular volume; LUSC trans rs11148252 0.574 rs2038826 chr13:53280013 G/A cg18335740 chr13:41363409 SLC25A15 0.77 13.82 0.6 1.12e-34 Lewy body disease; LUSC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg00745463 chr17:30367425 LRRC37B -0.66 -8.06 -0.4 1.41e-14 Hip circumference adjusted for BMI; LUSC cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg21427119 chr20:30132790 HM13 -0.42 -6.23 -0.32 1.38e-9 Mean corpuscular hemoglobin; LUSC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg15485101 chr11:133734466 NA 0.43 7.65 0.39 2.17e-13 Childhood ear infection; LUSC cis rs9677476 0.909 rs6437010 chr2:232113263 G/C cg07929768 chr2:232055508 NA 0.31 5.89 0.31 9.42e-9 Food antigen IgG levels; LUSC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.37 0.37 1.34e-12 Cognitive function; LUSC cis rs709400 0.663 rs1028613 chr14:103888324 G/A cg24130564 chr14:104152367 KLC1 -0.44 -6.14 -0.32 2.32e-9 Body mass index; LUSC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg12463550 chr7:65579703 CRCP 0.56 8.54 0.42 4.88e-16 Aortic root size; LUSC cis rs8017423 0.647 rs12590712 chr14:90822481 T/C cg04374321 chr14:90722782 PSMC1 -0.42 -6.39 -0.33 5.65e-10 Mortality in heart failure; LUSC cis rs7715806 0.500 rs2307115 chr5:74990348 T/C cg19683494 chr5:74908142 NA 0.59 8.03 0.4 1.68e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg06112835 chr11:68658793 MRPL21 -0.47 -7.31 -0.37 1.95e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4953076 0.573 rs13008237 chr2:44404902 A/G cg04920474 chr2:44395004 PPM1B 0.7 8.86 0.44 4.73e-17 Height; LUSC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg22963979 chr7:1858916 MAD1L1 0.56 8.84 0.44 5.71e-17 Bipolar disorder and schizophrenia; LUSC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg14983838 chr19:29218262 NA 0.65 9.07 0.44 1.06e-17 Methadone dose in opioid dependence; LUSC cis rs4766566 0.694 rs3843673 chr12:111746499 A/G cg10833066 chr12:111807467 FAM109A 0.54 10.07 0.48 5.41e-21 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC cis rs713587 0.713 rs12466350 chr2:25239969 A/G cg01884057 chr2:25150051 NA 0.38 8.5 0.42 6.49e-16 Body mass index in non-asthmatics; LUSC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 8.0 0.4 2.01e-14 Bipolar disorder; LUSC cis rs8064299 0.536 rs2290038 chr17:72786611 G/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.92 -17.51 -0.69 3.52e-49 Monocyte count; LUSC cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.34 -5.67 -0.3 3.11e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs73129298 0.551 rs4647959 chr20:48600557 T/C cg25655593 chr20:48599521 SNAI1 0.6 6.43 0.33 4.49e-10 Inflammatory skin disease; LUSC cis rs12368653 0.651 rs2277326 chr12:58202419 A/C cg12615879 chr12:58013172 SLC26A10 -0.37 -8.32 -0.41 2.35e-15 Multiple sclerosis; LUSC cis rs6835098 0.961 rs2877748 chr4:174102397 G/A cg08422745 chr4:174089978 GALNT7 -0.82 -13.33 -0.59 8.19e-33 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs11098499 0.954 rs6822679 chr4:120402702 A/C cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.57e-25 Corneal astigmatism; LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg02951883 chr7:2050386 MAD1L1 -0.64 -12.48 -0.56 1.34e-29 Bipolar disorder and schizophrenia; LUSC cis rs7917772 0.512 rs11594073 chr10:104308193 T/C cg22532475 chr10:104410764 TRIM8 0.26 6.12 0.32 2.6e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg24531977 chr5:56204891 C5orf35 -1.04 -16.0 -0.66 3.43e-43 Initial pursuit acceleration; LUSC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg13206674 chr6:150067644 NUP43 0.62 9.96 0.48 1.26e-20 Lung cancer; LUSC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg10621924 chr7:39171070 POU6F2 0.49 7.81 0.39 7.63e-14 IgG glycosylation; LUSC cis rs7608623 0.644 rs2339940 chr2:24251787 G/T cg08917208 chr2:24149416 ATAD2B -0.44 -5.93 -0.31 7.71e-9 Obesity-related traits; LUSC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22307029 chr19:49891270 CCDC155 0.68 9.57 0.46 2.55e-19 Multiple sclerosis; LUSC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.92 -0.35 2.25e-11 Lung cancer; LUSC cis rs5758659 0.652 rs133300 chr22:42389839 A/G cg04733989 chr22:42467013 NAGA 0.39 6.55 0.34 2.18e-10 Cognitive function; LUSC cis rs10887741 0.690 rs7908056 chr10:89444650 G/A cg13926569 chr10:89418898 PAPSS2 0.33 6.84 0.35 3.81e-11 Exercise (leisure time); LUSC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg10018233 chr7:150070692 REPIN1 0.38 6.67 0.34 1.06e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs9879311 0.643 rs1473183 chr3:10411827 C/T cg08489410 chr3:10329245 GHRL;GHRLOS 0.43 6.79 0.35 5.29e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs62103177 0.810 rs62103178 chr18:77624555 C/G cg05926928 chr17:57297772 GDPD1 1.44 16.72 0.68 5.09e-46 Opioid sensitivity; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg23123362 chr5:157158174 THG1L 0.76 6.37 0.33 6.28e-10 Body mass index; LUSC cis rs1124376 0.882 rs6791385 chr3:20136439 A/C cg05072819 chr3:20081367 KAT2B 0.67 8.19 0.41 5.56e-15 Bipolar disorder and schizophrenia; LUSC cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs7119 0.717 rs12910512 chr15:77817253 C/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.66 -0.34 1.13e-10 Type 2 diabetes; LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.7 -0.57 2.08e-30 Alzheimer's disease; LUSC cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg26446133 chr18:72167187 CNDP2 -0.85 -13.41 -0.59 4.32e-33 Refractive error; LUSC cis rs1461503 0.966 rs11218907 chr11:122841562 A/G cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC cis rs7107356 1 rs7107356 chr11:47676170 A/G cg20135002 chr11:47629003 NA 0.34 5.79 0.3 1.65e-8 Neuroticism;Neuroticism (multi-trait analysis); LUSC cis rs7772486 0.875 rs9390371 chr6:146363180 A/G cg23711669 chr6:146136114 FBXO30 0.85 15.26 0.64 2.8e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.836 rs6142284 chr20:33641367 G/A cg07148914 chr20:33460835 GGT7 -0.45 -6.66 -0.34 1.1e-10 Height; LUSC cis rs7428496 0.528 rs13092593 chr3:142213824 G/A cg16271453 chr3:142027066 XRN1 -0.51 -8.95 -0.44 2.6e-17 Mean corpuscular hemoglobin; LUSC cis rs73206853 0.764 rs73206857 chr12:110767721 T/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs11153147 0.655 rs117298489 chr6:109432996 T/G cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Mean corpuscular volume; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26526036 chr4:183838753 DCTD 0.4 6.74 0.35 6.94e-11 Asthma; LUSC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg19230755 chr7:65878503 NA 0.41 5.84 0.3 1.24e-8 Aortic root size; LUSC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg22800045 chr5:56110881 MAP3K1 0.43 5.99 0.31 5.46e-9 Coronary artery disease; LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg16325326 chr1:53192061 ZYG11B 0.88 16.0 0.66 3.49e-43 Monocyte count; LUSC cis rs4363385 0.747 rs2339491 chr1:152985322 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.86 -0.39 5.44e-14 Inflammatory skin disease; LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs2730245 0.527 rs2788470 chr7:158649801 G/T cg24397884 chr7:158709396 WDR60 0.76 8.35 0.42 1.88e-15 Height; LUSC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg05855489 chr10:104503620 C10orf26 0.52 7.83 0.39 6.44e-14 Arsenic metabolism; LUSC trans rs6762477 0.748 rs11711407 chr3:50225029 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -7.25 -0.37 2.89e-12 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01674679 chr13:27998804 GTF3A -0.47 -6.96 -0.36 1.84e-11 Electrocardiographic conduction measures; LUSC cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg00509249 chr6:109615579 CCDC162 -0.34 -6.14 -0.32 2.4e-9 Reticulocyte fraction of red cells; LUSC cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg05535760 chr7:792225 HEATR2 0.76 9.1 0.45 8.65e-18 Cerebrospinal P-tau181p levels; LUSC cis rs4629180 0.920 rs4851458 chr2:102108794 T/C cg01388757 chr2:102091195 RFX8 -0.46 -7.42 -0.38 1.01e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg03188948 chr7:1209495 NA 0.64 6.88 0.35 2.88e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2486288 0.656 rs11632920 chr15:45551264 C/T cg14582100 chr15:45693742 SPATA5L1 -0.41 -7.55 -0.38 4.27e-13 Glomerular filtration rate; LUSC cis rs868036 0.681 rs4776976 chr15:68103291 C/T cg05925327 chr15:68127851 NA -0.41 -6.46 -0.33 3.79e-10 Restless legs syndrome; LUSC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg22800045 chr5:56110881 MAP3K1 0.79 10.35 0.49 6.04e-22 Initial pursuit acceleration; LUSC cis rs4595586 0.655 rs11831502 chr12:39310127 A/T cg26384229 chr12:38710491 ALG10B 0.45 6.16 0.32 2.09e-9 Morning vs. evening chronotype; LUSC cis rs4356932 1.000 rs4859414 chr4:76949997 G/A cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg17264618 chr3:40429014 ENTPD3 0.3 6.53 0.34 2.51e-10 Renal cell carcinoma; LUSC cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg21466736 chr12:48725269 NA -0.32 -5.71 -0.3 2.56e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7605827 0.930 rs12989038 chr2:15549862 A/T cg19274914 chr2:15703543 NA 0.45 8.62 0.43 2.78e-16 Educational attainment (years of education); LUSC cis rs6688613 0.694 rs12062326 chr1:166820186 G/A cg07049167 chr1:166818506 POGK 0.54 8.05 0.4 1.42e-14 Refractive astigmatism; LUSC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11890956 chr21:40555474 PSMG1 1.03 20.82 0.75 2.6e-62 Cognitive function; LUSC cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg18964960 chr10:1102726 WDR37 -0.46 -6.16 -0.32 2.09e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs1107366 1.000 rs9873704 chr3:125901902 G/C cg08481491 chr3:125900108 ALDH1L1 -0.32 -6.52 -0.34 2.67e-10 Metabolite levels; LUSC cis rs9633740 0.578 rs11185951 chr10:82301536 G/C cg01528321 chr10:82214614 TSPAN14 -0.82 -7.27 -0.37 2.55e-12 Post bronchodilator FEV1; LUSC cis rs9300255 0.739 rs1980252 chr12:123745178 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.18 -0.32 1.82e-9 Neutrophil percentage of white cells; LUSC cis rs7075426 0.789 rs7083506 chr10:88199668 A/G cg07322936 chr10:88137208 NA 0.48 6.9 0.35 2.61e-11 Migraine without aura; LUSC trans rs11250098 0.548 rs7837038 chr8:10783074 G/A cg15556689 chr8:8085844 FLJ10661 -0.54 -7.81 -0.39 7.37e-14 Morning vs. evening chronotype; LUSC cis rs7929679 0.521 rs11499809 chr11:34790743 C/T cg06937548 chr11:34938143 PDHX;APIP 0.4 5.91 0.31 8.29e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg26116260 chr4:7069785 GRPEL1 1.14 16.7 0.67 5.82e-46 Monocyte percentage of white cells; LUSC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg18876405 chr7:65276391 NA -0.58 -9.38 -0.46 1.08e-18 Aortic root size; LUSC cis rs11122272 0.735 rs2808595 chr1:231526238 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.01 0.48 8.18e-21 Hemoglobin concentration; LUSC cis rs765787 0.530 rs1706834 chr15:45517854 G/A cg25801113 chr15:45476975 SHF 0.35 7.12 0.36 6.47e-12 Uric acid levels; LUSC cis rs2414856 0.510 rs12102207 chr15:64607472 A/G cg08069370 chr15:64387884 SNX1 -0.73 -6.43 -0.33 4.3e-10 Pulse pressure;Systolic blood pressure; LUSC trans rs2392780 0.536 rs444318 chr8:128333513 A/G cg10897648 chr18:56338258 MALT1 -0.41 -6.3 -0.33 9.46e-10 Breast cancer (early onset); LUSC trans rs11098499 1.000 rs6849889 chr4:120186348 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.44 6.05 0.31 3.86e-9 Corneal astigmatism; LUSC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg18876405 chr7:65276391 NA -0.56 -8.93 -0.44 2.9e-17 Aortic root size; LUSC cis rs7615316 0.934 rs9855140 chr3:142190101 T/C cg16271453 chr3:142027066 XRN1 -0.4 -6.87 -0.35 3.22e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6964587 1.000 rs10245095 chr7:91710845 A/G cg17063962 chr7:91808500 NA 0.56 8.91 0.44 3.45e-17 Breast cancer; LUSC cis rs1863824 0.625 rs10887598 chr10:88166160 T/A cg07322936 chr10:88137208 NA -0.66 -9.68 -0.47 1.1e-19 Schizophrenia; LUSC trans rs12439619 0.846 rs28697264 chr15:82557900 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.48 -6.48 -0.33 3.35e-10 Intelligence (multi-trait analysis); LUSC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg03517284 chr6:25882590 NA -0.48 -8.09 -0.4 1.15e-14 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02259698 chr2:10953349 PDIA6 -0.51 -6.06 -0.31 3.69e-9 Bipolar disorder and schizophrenia; LUSC cis rs9398803 0.678 rs9388500 chr6:126876580 C/G cg19875578 chr6:126661172 C6orf173 0.4 5.91 0.31 8.55e-9 Male-pattern baldness; LUSC cis rs9443645 0.527 rs36128361 chr6:79684340 C/G cg05283184 chr6:79620031 NA -0.45 -8.66 -0.43 1.98e-16 Intelligence (multi-trait analysis); LUSC cis rs9788682 1.000 rs57064725 chr15:78833036 C/A cg18825076 chr15:78729989 IREB2 0.45 6.24 0.32 1.36e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7937682 0.632 rs4936834 chr11:111764017 T/A cg09085632 chr11:111637200 PPP2R1B 0.93 12.47 0.56 1.45e-29 Primary sclerosing cholangitis; LUSC trans rs853679 0.546 rs493161 chr6:27850714 A/T cg01620082 chr3:125678407 NA -0.74 -7.08 -0.36 8.67e-12 Depression; LUSC cis rs2573652 0.755 rs6598286 chr15:100515985 G/T cg00587665 chr15:100533223 ADAMTS17 -0.38 -6.13 -0.32 2.44e-9 Height; LUSC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg06740227 chr12:86229804 RASSF9 -0.38 -6.11 -0.32 2.79e-9 Major depressive disorder; LUSC cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg26898376 chr11:64110657 CCDC88B 0.33 6.17 0.32 1.92e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs644799 0.511 rs11021301 chr11:95485145 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.55 7.34 0.37 1.64e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg06145435 chr7:1022769 CYP2W1 0.31 6.4 0.33 5.39e-10 Longevity;Endometriosis; LUSC cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13064411 0.696 rs9869318 chr3:113146271 T/C cg18753928 chr3:113234510 CCDC52 -0.5 -7.5 -0.38 5.89e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs467650 0.549 rs162676 chr5:97991503 C/T cg03885343 chr5:98108198 RGMB 0.3 5.78 0.3 1.75e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg10729496 chr3:10149963 C3orf24 -0.6 -8.44 -0.42 9.55e-16 Alzheimer's disease; LUSC cis rs11098499 0.691 rs9996494 chr4:120238880 C/A cg09307838 chr4:120376055 NA 0.7 10.41 0.5 3.52e-22 Corneal astigmatism; LUSC cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg24642439 chr20:33292090 TP53INP2 0.53 8.35 0.42 1.84e-15 Coronary artery disease; LUSC cis rs611744 0.523 rs13253581 chr8:109343105 A/G cg18478394 chr8:109455254 TTC35 0.45 6.91 0.35 2.51e-11 Dupuytren's disease; LUSC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.57e-8 Menopause (age at onset); LUSC trans rs2797160 1.000 rs6927161 chr6:126015954 T/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.88 0.35 3.01e-11 Endometrial cancer; LUSC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg09165964 chr15:75287851 SCAMP5 -1.01 -15.08 -0.64 1.44e-39 Blood trace element (Zn levels); LUSC cis rs3540 0.533 rs11633692 chr15:91056043 G/A cg10434728 chr15:90938212 IQGAP1 -0.45 -9.05 -0.44 1.22e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs362272 0.545 rs2748447 chr4:3337831 G/A cg18352616 chr4:3374830 RGS12 0.31 6.0 0.31 5.26e-9 Serum sulfate level; LUSC cis rs7903847 0.620 rs10882907 chr10:99125788 C/G cg20016023 chr10:99160130 RRP12 0.29 7.1 0.36 7.74e-12 Granulocyte percentage of myeloid white cells; LUSC trans rs7618501 0.633 rs9814664 chr3:50078541 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.42 -0.46 7.55e-19 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg11060661 chr22:24314208 DDT;DDTL -0.47 -7.64 -0.39 2.32e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg21535247 chr6:8435926 SLC35B3 0.59 9.19 0.45 4.15e-18 Motion sickness; LUSC cis rs4727027 0.704 rs12537763 chr7:148903984 G/A cg23583168 chr7:148888333 NA -0.88 -17.41 -0.69 9.46e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg09904177 chr6:26538194 HMGN4 -0.73 -14.17 -0.61 5.11e-36 Intelligence (multi-trait analysis); LUSC cis rs9469578 0.892 rs6929527 chr6:33707976 G/T cg18708504 chr6:33715942 IP6K3 0.72 8.99 0.44 1.93e-17 Phosphorus levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25333056 chr10:135107159 TUBGCP2 -0.34 -6.09 -0.32 3.14e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg26061582 chr7:22766209 IL6 0.52 7.64 0.39 2.32e-13 Cerebrospinal fluid clusterin levels in APOEe4- carriers; LUSC trans rs12439619 0.693 rs8034801 chr15:82476337 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.44 -6.25 -0.32 1.27e-9 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg07507251 chr3:52567010 NT5DC2 0.34 6.59 0.34 1.68e-10 Bipolar disorder; LUSC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg06112835 chr11:68658793 MRPL21 0.48 7.44 0.38 8.49e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7215564 0.908 rs4889783 chr17:78667160 C/T cg09596252 chr17:78655493 RPTOR 0.52 5.67 0.3 3.1e-8 Myopia (pathological); LUSC cis rs7267979 0.509 rs6115218 chr20:25566485 A/G cg14121845 chr20:25566513 NINL 0.44 7.21 0.37 3.76e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg10356904 chr22:49881777 NA -0.3 -6.72 -0.35 7.74e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2115536 0.730 rs12898642 chr15:80182050 T/C cg02196730 chr15:80188777 MTHFS 0.4 6.02 0.31 4.5e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11890956 chr21:40555474 PSMG1 1.04 21.37 0.76 1.82e-64 Cognitive function; LUSC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.33 0.37 1.79e-12 Cognitive function; LUSC cis rs11785400 0.928 rs10100287 chr8:143734836 C/T cg24634471 chr8:143751801 JRK 0.59 8.99 0.44 1.82e-17 Schizophrenia; LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg00431813 chr7:1051703 C7orf50 -0.38 -5.99 -0.31 5.42e-9 Longevity;Endometriosis; LUSC cis rs559928 0.569 rs7103915 chr11:63944370 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.64 -6.22 -0.32 1.5e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg14004847 chr7:1930337 MAD1L1 -0.55 -8.38 -0.42 1.45e-15 Bipolar disorder and schizophrenia; LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.53 0.34 2.5e-10 Menopause (age at onset); LUSC cis rs2880765 0.566 rs55899824 chr15:86004091 C/T cg10818794 chr15:86012489 AKAP13 -0.42 -6.72 -0.35 7.82e-11 Coronary artery disease; LUSC cis rs11630290 0.592 rs12324668 chr15:64161786 A/T cg12036633 chr15:63758958 NA 0.56 7.17 0.37 4.94e-12 Iris characteristics; LUSC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg24531977 chr5:56204891 C5orf35 -0.98 -14.66 -0.63 6.33e-38 Initial pursuit acceleration; LUSC cis rs9837602 0.938 rs9873709 chr3:99711687 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.15 0.32 2.17e-9 Breast cancer; LUSC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg19418458 chr7:158789849 NA 0.49 8.16 0.41 6.96e-15 Facial morphology (factor 20); LUSC cis rs6733011 0.578 rs1581250 chr2:99500750 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.87 -0.35 3.1e-11 Bipolar disorder; LUSC cis rs9648716 0.515 rs17695935 chr7:140507937 A/T cg23214464 chr7:140373596 ADCK2 0.69 5.98 0.31 5.66e-9 Type 2 diabetes; LUSC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.6 -0.38 3.1e-13 Aortic root size; LUSC cis rs6681460 0.899 rs499263 chr1:67179937 T/C cg02459107 chr1:67143332 SGIP1 0.47 8.71 0.43 1.38e-16 Presence of antiphospholipid antibodies; LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg00166722 chr3:10149974 C3orf24 0.55 7.46 0.38 7.77e-13 Alzheimer's disease; LUSC trans rs9503598 0.636 rs6596977 chr6:3466254 G/A cg05722439 chr19:14072965 RFX1 -0.31 -6.04 -0.31 4.06e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs6546537 0.824 rs55864699 chr2:69803650 C/T cg10773587 chr2:69614142 GFPT1 -0.56 -8.73 -0.43 1.25e-16 Serum thyroid-stimulating hormone levels; LUSC cis rs1113500 0.702 rs11185262 chr1:108639742 C/T cg06207961 chr1:108661230 NA 0.42 7.68 0.39 1.82e-13 Growth-regulated protein alpha levels; LUSC cis rs6547741 0.935 rs12615690 chr2:27851120 T/C cg12559939 chr2:27858050 GPN1 0.4 6.21 0.32 1.57e-9 Oral cavity cancer; LUSC trans rs72674100 1.000 rs9995442 chr4:97963208 A/G cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs61931739 0.892 rs61931711 chr12:34045374 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs1847202 0.826 rs13063441 chr3:72952400 A/G cg25664220 chr3:72788482 NA -0.45 -7.98 -0.4 2.45e-14 Motion sickness; LUSC cis rs500891 0.553 rs6454329 chr6:84171532 A/T cg08257003 chr6:84140564 ME1 0.35 8.71 0.43 1.43e-16 Platelet-derived growth factor BB levels; LUSC cis rs1559088 0.649 rs4528686 chr19:33556074 A/G cg27124370 chr19:33622961 WDR88 0.53 6.69 0.34 9.21e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg01503450 chr10:980765 NA -0.37 -5.74 -0.3 2.13e-8 Eosinophil percentage of granulocytes; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03352830 chr11:487213 PTDSS2 0.73 8.44 0.42 9.94e-16 Body mass index; LUSC cis rs7804356 1.000 rs1327988 chr7:26828965 C/G cg03456212 chr7:26904342 SKAP2 0.54 6.27 0.32 1.13e-9 Type 1 diabetes; LUSC trans rs3960554 0.610 rs10265696 chr7:75766712 G/A cg19862616 chr7:65841803 NCRNA00174 0.88 9.81 0.47 3.89e-20 Eotaxin levels; LUSC cis rs11030122 0.702 rs4910868 chr11:3980224 A/C cg18678763 chr11:4115507 RRM1 -0.47 -6.0 -0.31 5.25e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg03517284 chr6:25882590 NA -0.53 -8.81 -0.43 6.74e-17 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.28e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg05234568 chr11:5960015 NA -0.57 -8.35 -0.42 1.81e-15 DNA methylation (variation); LUSC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg06481639 chr22:41940642 POLR3H -0.53 -6.02 -0.31 4.55e-9 Vitiligo; LUSC cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7809950 1.000 rs2520260 chr7:107172794 A/G cg23024343 chr7:107201750 COG5 -0.56 -8.81 -0.43 7.12e-17 Coronary artery disease; LUSC trans rs6601327 1.000 rs6601327 chr8:9395532 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.79 -0.35 5.08e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs16854884 1.000 rs13068298 chr3:143772247 T/C cg06585982 chr3:143692056 C3orf58 0.48 6.93 0.35 2.23e-11 Economic and political preferences (feminism/equality); LUSC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg18479299 chr3:125709523 NA -0.5 -5.79 -0.3 1.66e-8 Blood pressure (smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03565782 chr1:181057814 IER5 -0.41 -6.13 -0.32 2.55e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9297145 0.678 rs62473007 chr7:98749598 G/C cg05967295 chr7:98741636 SMURF1 0.94 13.86 0.6 7.82e-35 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs3862030 0.720 rs12569526 chr10:104237007 A/G cg05855489 chr10:104503620 C10orf26 0.5 7.68 0.39 1.8e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2404602 0.692 rs35170561 chr15:77130695 C/T cg22467129 chr15:76604101 ETFA -0.44 -6.97 -0.36 1.71e-11 Blood metabolite levels; LUSC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg16049864 chr8:95962084 TP53INP1 -0.65 -12.06 -0.55 4.59e-28 Type 2 diabetes; LUSC cis rs977987 0.843 rs35737321 chr16:75439185 A/T cg03315344 chr16:75512273 CHST6 0.53 10.16 0.49 2.69e-21 Dupuytren's disease; LUSC cis rs7705502 1.000 rs56184817 chr5:173367586 T/C cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.3e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 12.39 0.56 2.97e-29 Personality dimensions; LUSC cis rs12195417 0.563 rs499872 chr6:84217403 C/T cg08257003 chr6:84140564 ME1 -0.28 -6.66 -0.34 1.15e-10 Schizophrenia; LUSC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs12940923 1.000 rs11868285 chr17:56371181 C/T cg19466818 chr17:56409534 MIR142 -0.38 -6.76 -0.35 6.25e-11 Circulating myeloperoxidase levels (plasma); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21678189 chr6:10838625 NA -0.52 -6.36 -0.33 6.66e-10 Bipolar disorder and schizophrenia; LUSC cis rs9902453 0.704 rs2617874 chr17:28085172 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.19 0.45 4.35e-18 Coffee consumption (cups per day); LUSC cis rs1863824 0.625 rs2018507 chr10:88163251 A/G cg07322936 chr10:88137208 NA 0.68 10.15 0.49 2.91e-21 Schizophrenia; LUSC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg23630131 chr7:65973040 NA -0.21 -5.8 -0.3 1.56e-8 Aortic root size; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.97 -0.4 2.62e-14 Lymphocyte counts; LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg07507251 chr3:52567010 NT5DC2 0.36 6.56 0.34 2.07e-10 Bipolar disorder; LUSC trans rs9329221 0.967 rs7005363 chr8:10283748 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.66 -0.39 2.09e-13 Neuroticism; LUSC cis rs7589342 0.899 rs11885225 chr2:106486548 T/C cg16077055 chr2:106428750 NCK2 0.32 5.94 0.31 7.26e-9 Addiction; LUSC cis rs2932538 0.961 rs4839257 chr1:113219388 A/T cg22162597 chr1:113214053 CAPZA1 -0.55 -7.97 -0.4 2.49e-14 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs2688608 0.967 rs9971040 chr10:75661162 G/C cg17411546 chr10:75410026 SYNPO2L -0.42 -6.16 -0.32 2.05e-9 Inflammatory bowel disease; LUSC cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -8.3 -0.41 2.64e-15 Schizophrenia; LUSC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg11247378 chr22:39784982 NA -0.6 -10.35 -0.49 5.76e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs1577917 0.958 rs1545376 chr6:86504582 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 6.74 0.35 6.82e-11 Response to antipsychotic treatment; LUSC cis rs17253792 0.818 rs78393484 chr14:56065802 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs11051970 0.636 rs2733704 chr12:32567858 C/T cg02745156 chr12:32552066 NA 0.38 7.01 0.36 1.34e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg00814883 chr7:100076585 TSC22D4 -0.66 -8.64 -0.43 2.36e-16 Platelet count; LUSC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.5 -0.38 5.85e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11105298 0.891 rs4842662 chr12:89933446 T/C cg00757033 chr12:89920650 WDR51B 0.61 10.77 0.51 2.12e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs4332037 0.851 rs34040190 chr7:1920356 G/A cg10840412 chr1:235813424 GNG4 0.71 8.74 0.43 1.12e-16 Bipolar disorder; LUSC cis rs36093844 0.706 rs116940726 chr11:85584052 A/C cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg13010199 chr12:38710504 ALG10B -0.58 -9.11 -0.45 8.04e-18 Bladder cancer; LUSC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg23711669 chr6:146136114 FBXO30 0.87 15.63 0.65 1.03e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs7582180 0.652 rs11694700 chr2:100936637 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.78 0.3 1.76e-8 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg02269571 chr22:50332266 NA -0.59 -8.58 -0.43 3.52e-16 Schizophrenia; LUSC cis rs11250098 0.547 rs2409764 chr8:11281273 C/T cg27411982 chr8:10470053 RP1L1 0.42 6.47 0.33 3.48e-10 Morning vs. evening chronotype; LUSC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg07777115 chr5:623756 CEP72 -0.45 -5.7 -0.3 2.62e-8 Obesity-related traits; LUSC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg21972741 chr5:435613 AHRR 0.37 6.99 0.36 1.47e-11 Cystic fibrosis severity; LUSC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC trans rs11098499 0.954 rs6834796 chr4:120414693 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.61 0.34 1.52e-10 Corneal astigmatism; LUSC cis rs6541297 0.941 rs2180078 chr1:230280513 T/C cg20703242 chr1:230279135 GALNT2 0.57 8.7 0.43 1.55e-16 Coronary artery disease; LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg19318889 chr4:1322082 MAEA 0.44 6.78 0.35 5.38e-11 Obesity-related traits; LUSC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg11764359 chr7:65958608 NA 0.54 7.0 0.36 1.39e-11 Aortic root size; LUSC cis rs2439831 1.000 rs690316 chr15:43737880 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.98 11.27 0.52 3.59e-25 Lung cancer in ever smokers; LUSC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg26597838 chr10:835615 NA 0.97 13.28 0.59 1.3e-32 Eosinophil percentage of granulocytes; LUSC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.35 -0.33 7.17e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9341835 0.772 rs9344090 chr6:64135830 G/A cg00787780 chr6:64151745 NA -0.34 -5.78 -0.3 1.72e-8 Schizophrenia; LUSC cis rs7766436 0.848 rs2294828 chr6:22598018 G/A cg13666174 chr6:22585274 NA -0.42 -5.72 -0.3 2.38e-8 Coronary artery disease; LUSC cis rs7267979 0.933 rs2424708 chr20:25281398 C/T cg08601574 chr20:25228251 PYGB 0.42 6.47 0.33 3.46e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs259282 0.605 rs28615461 chr19:33110149 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.64 9.5 0.46 4.33e-19 Schizophrenia; LUSC cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg22963979 chr7:1858916 MAD1L1 -0.62 -9.8 -0.47 4.16e-20 Bipolar disorder and schizophrenia; LUSC cis rs4400599 0.838 rs2494667 chr1:154109153 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 0.36 5.84 0.3 1.24e-8 Platelet distribution width; LUSC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.95 0.48 1.38e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9527 0.590 rs10883820 chr10:104764661 A/C cg04362960 chr10:104952993 NT5C2 -0.62 -9.85 -0.47 3e-20 Arsenic metabolism; LUSC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11890956 chr21:40555474 PSMG1 0.98 16.61 0.67 1.37e-45 Cognitive function; LUSC cis rs7223966 1.000 rs9891018 chr17:61827856 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 7.06 0.36 9.81e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9309473 0.539 rs6732440 chr2:73827099 T/G cg20560298 chr2:73613845 ALMS1 0.51 7.8 0.39 7.8500000000000006e-14 Metabolite levels; LUSC cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 8.32 0.41 2.25e-15 Colorectal cancer; LUSC cis rs73200209 0.744 rs17498452 chr12:116538854 C/T cg01776926 chr12:116560359 MED13L 0.48 5.81 0.3 1.42e-8 Total body bone mineral density; LUSC cis rs778371 0.676 rs17164 chr2:233593499 C/T cg08000102 chr2:233561755 GIGYF2 0.79 12.81 0.57 8.05e-31 Schizophrenia; LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8e-17 Bipolar disorder; LUSC cis rs7824557 0.564 rs2736300 chr8:11235579 T/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.01 -0.31 4.97e-9 Retinal vascular caliber; LUSC cis rs7599312 0.534 rs10182996 chr2:213404834 T/C cg20637307 chr2:213403960 ERBB4 0.44 7.51 0.38 5.38e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg07424592 chr7:64974309 NA 0.69 6.2 0.32 1.68e-9 Diabetic kidney disease; LUSC trans rs10877945 0.702 rs12820630 chr12:63400179 A/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -0.39 -6.69 -0.34 9.41e-11 Obesity-related traits; LUSC cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg21535247 chr6:8435926 SLC35B3 0.6 9.27 0.45 2.37e-18 Motion sickness; LUSC trans rs12210905 0.925 rs6920115 chr6:26988417 T/C cg11837749 chr1:55047332 ACOT11 0.55 5.96 0.31 6.41e-9 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg07701084 chr6:150067640 NUP43 0.57 8.79 0.43 7.84e-17 Lung cancer; LUSC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg00343986 chr7:65444356 GUSB 0.47 7.02 0.36 1.26e-11 Aortic root size; LUSC cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.94 -0.31 7.19e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg14830952 chr8:86089500 E2F5 0.39 5.94 0.31 6.97e-9 Calcium levels; LUSC trans rs2228479 0.764 rs7184960 chr16:89961661 C/T cg24644049 chr4:85504048 CDS1 0.73 7.36 0.37 1.41e-12 Skin colour saturation; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09372928 chr1:6845395 CAMTA1 -0.49 -6.61 -0.34 1.56e-10 Bipolar disorder and schizophrenia; LUSC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg07741184 chr6:167504864 NA -0.39 -7.09 -0.36 7.98e-12 Lung cancer; LUSC trans rs800082 0.516 rs1178892 chr3:144238173 A/G cg24215973 chr2:240111563 HDAC4 0.45 6.98 0.36 1.6e-11 Smoking behavior; LUSC cis rs3812831 0.635 rs6560937 chr13:114945991 C/G cg15896084 chr13:114927664 NA 0.39 7.21 0.37 3.66e-12 Schizophrenia; LUSC cis rs9303401 0.614 rs28687626 chr17:57191904 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.84 11.93 0.55 1.48e-27 Cognitive test performance; LUSC cis rs11583043 0.668 rs6681915 chr1:101558521 G/A cg11406453 chr1:101602562 NA -0.41 -6.86 -0.35 3.39e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9369695 0.842 rs2396825 chr6:47568696 A/G cg02130027 chr6:47444894 CD2AP 0.35 5.76 0.3 1.92e-8 Reticulocyte count; LUSC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs6740322 0.857 rs11690012 chr2:43542480 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.46 -6.48 -0.33 3.24e-10 Coronary artery disease; LUSC cis rs4692589 0.743 rs3806825 chr4:170948619 T/C cg19918862 chr4:170955249 NA 0.33 6.45 0.33 3.94e-10 Anxiety disorder; LUSC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg06697600 chr4:7070879 GRPEL1 0.45 6.42 0.33 4.8e-10 Monocyte percentage of white cells; LUSC cis rs5769765 0.773 rs138834 chr22:50180497 A/C cg02269571 chr22:50332266 NA -0.5 -7.36 -0.37 1.4e-12 Schizophrenia; LUSC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg08280861 chr8:58055591 NA 0.52 5.73 0.3 2.21e-8 Developmental language disorder (linguistic errors); LUSC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg22800045 chr5:56110881 MAP3K1 -0.6 -8.49 -0.42 6.89e-16 Initial pursuit acceleration; LUSC cis rs1371867 0.846 rs1660330 chr8:101305015 T/A cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.93e-13 Atrioventricular conduction; LUSC cis rs7072216 0.843 rs4400721 chr10:100147097 C/T cg26618903 chr10:100175079 PYROXD2 -0.34 -6.45 -0.33 3.92e-10 Metabolite levels; LUSC cis rs17881320 0.510 rs6503699 chr17:40554261 C/G cg05878104 chr17:40932452 WNK4 0.7 7.94 0.4 3.02e-14 Atopic dermatitis; LUSC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg10621924 chr7:39171070 POU6F2 0.49 7.69 0.39 1.62e-13 IgG glycosylation; LUSC cis rs7772486 0.902 rs1331643 chr6:146398873 T/A cg23711669 chr6:146136114 FBXO30 0.77 13.57 0.6 1.08e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg03240473 chr21:43526662 UMODL1;C21orf128 -0.45 -7.29 -0.37 2.25e-12 IgG glycosylation; LUSC cis rs7267979 1.000 rs2500446 chr20:25339664 C/T cg08601574 chr20:25228251 PYGB -0.44 -6.8 -0.35 4.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.33 0.45 1.52e-18 Prudent dietary pattern; LUSC cis rs10791323 0.601 rs7946883 chr11:133733864 T/C cg15485101 chr11:133734466 NA 0.41 7.72 0.39 1.32e-13 Childhood ear infection; LUSC cis rs1577917 0.560 rs9450288 chr6:86221586 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.4 6.18 0.32 1.88e-9 Response to antipsychotic treatment; LUSC cis rs829883 0.902 rs829884 chr12:98879500 C/G cg25150519 chr12:98850993 NA 0.64 10.02 0.48 7.74e-21 Colorectal adenoma (advanced); LUSC cis rs3809863 0.602 rs11650072 chr17:45393665 A/G cg08085267 chr17:45401833 C17orf57 -0.67 -10.32 -0.49 7.15e-22 Glaucoma (primary open-angle); LUSC cis rs6733011 0.508 rs925887 chr2:99514671 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.49 6.87 0.35 3.16e-11 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05492810 chr11:78129288 GAB2 0.42 6.35 0.33 7.21e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs734999 0.611 rs10797431 chr1:2501222 G/T cg18932078 chr1:2524107 MMEL1 0.29 6.44 0.33 4.05e-10 Ulcerative colitis; LUSC cis rs1467026 0.719 rs17037220 chr3:12818103 A/G cg05775895 chr3:12838266 CAND2 0.51 8.64 0.43 2.33e-16 P wave duration; LUSC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg04369109 chr6:150039330 LATS1 -0.55 -8.18 -0.41 5.94e-15 Lung cancer; LUSC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg05393297 chr12:53359155 NA -0.6 -9.64 -0.47 1.44e-19 Prostate cancer; LUSC trans rs7824557 0.564 rs13274106 chr8:11233958 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.69 -0.39 1.67e-13 Retinal vascular caliber; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17602776 chr5:178977377 RUFY1 0.44 6.02 0.31 4.67e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1376359 0.576 rs2783561 chr1:103257429 C/A cg17154563 chr19:40477487 PSMC4 0.48 6.06 0.31 3.61e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05256447 chr13:22245171 FGF9 -0.42 -6.02 -0.31 4.57e-9 Electrocardiographic conduction measures; LUSC cis rs3768617 0.510 rs6424889 chr1:183091796 G/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.94 0.51 4.97e-24 Fuchs's corneal dystrophy; LUSC cis rs367943 0.666 rs10074214 chr5:112702214 A/G cg12552261 chr5:112820674 MCC 0.35 5.69 0.3 2.75e-8 Type 2 diabetes; LUSC cis rs8099014 1.000 rs7241204 chr18:56130246 G/A cg12907477 chr18:56117327 MIR122 0.44 7.04 0.36 1.11e-11 Platelet count; LUSC cis rs4589502 0.841 rs55855162 chr15:67140523 C/A cg09911534 chr15:67153556 NA -0.64 -7.22 -0.37 3.52e-12 Lung cancer (smoking interaction); LUSC cis rs174601 0.861 rs174580 chr11:61606642 A/G cg19610905 chr11:61596333 FADS2 -0.49 -7.55 -0.38 4.31e-13 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC cis rs7191439 0.789 rs4598894 chr16:88776141 G/A cg27087555 chr16:88793112 FAM38A -1.5 -12.57 -0.57 6.05e-30 Plateletcrit; LUSC cis rs17102423 0.531 rs2763888 chr14:65571493 T/C cg11161011 chr14:65562177 MAX -0.72 -10.92 -0.51 6.28e-24 Obesity-related traits; LUSC cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg08085267 chr17:45401833 C17orf57 0.6 9.93 0.48 1.62e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg04234412 chr22:24373322 LOC391322 -0.85 -15.04 -0.64 2.21e-39 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7937682 0.889 rs2850247 chr11:111637202 C/A cg22437258 chr11:111473054 SIK2 -0.51 -6.96 -0.36 1.86e-11 Primary sclerosing cholangitis; LUSC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg04369109 chr6:150039330 LATS1 -0.54 -7.99 -0.4 2.21e-14 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04632724 chr15:102192393 TM2D3 -0.45 -6.26 -0.32 1.16e-9 Bipolar disorder and schizophrenia; LUSC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg12564285 chr5:131593104 PDLIM4 0.44 8.14 0.41 8.12e-15 Breast cancer; LUSC cis rs4363385 0.693 rs4845497 chr1:152904162 T/C cg07796016 chr1:152779584 LCE1C -0.46 -6.57 -0.34 1.98e-10 Inflammatory skin disease; LUSC cis rs734999 0.566 rs6424092 chr1:2532899 C/A cg18932078 chr1:2524107 MMEL1 -0.33 -7.17 -0.37 4.74e-12 Ulcerative colitis; LUSC cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -10.27 -0.49 1.11e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg17507749 chr15:85114479 UBE2QP1 0.7 8.87 0.44 4.59e-17 Schizophrenia; LUSC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg19230755 chr7:65878503 NA -0.42 -6.02 -0.31 4.6e-9 Aortic root size; LUSC trans rs1997103 1.000 rs10224446 chr7:55413147 C/G cg20935933 chr6:143382018 AIG1 0.51 7.38 0.37 1.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6847149 0.929 rs4698798 chr4:110792629 C/T cg07850274 chr4:110748770 RRH -0.57 -8.66 -0.43 2.1e-16 Exercise treadmill test traits; LUSC trans rs9929218 1.000 rs2113200 chr16:68814948 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.7 -10.32 -0.49 7.63e-22 Colorectal cancer; LUSC cis rs12210905 0.764 rs72835248 chr6:26931817 G/A cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.84 -0.3 1.26e-8 Hip circumference adjusted for BMI; LUSC cis rs11112613 0.762 rs66754070 chr12:105949779 G/A cg03607813 chr12:105948248 NA 0.82 12.43 0.56 2.01e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.89 0.55 2.01e-27 Prudent dietary pattern; LUSC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg05347473 chr6:146136440 FBXO30 -0.66 -11.3 -0.53 2.81e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs9300255 0.602 rs1727316 chr12:123618603 C/T cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.05 -0.31 3.79e-9 Neutrophil percentage of white cells; LUSC cis rs9837602 0.882 rs6807176 chr3:99760864 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.36 0.33 6.81e-10 Breast cancer; LUSC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.54 -0.34 2.29e-10 Lung cancer; LUSC cis rs10493773 0.609 rs11161664 chr1:86185379 C/T cg17807903 chr1:86174739 ZNHIT6 -0.55 -15.08 -0.64 1.42e-39 Urate levels in overweight individuals; LUSC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg15110403 chr19:17392923 ANKLE1 -0.52 -7.17 -0.37 4.89e-12 Systemic lupus erythematosus; LUSC cis rs974417 0.529 rs13196850 chr6:97318086 T/C cg10979063 chr6:97285822 GPR63 0.45 7.47 0.38 7.26e-13 Body mass index; LUSC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11644478 chr21:40555479 PSMG1 0.95 19.43 0.73 8.13e-57 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08530030 chr7:44530236 NUDCD3 -0.42 -6.12 -0.32 2.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10782582 0.593 rs12142247 chr1:76235746 C/T cg03433033 chr1:76189801 ACADM -0.45 -6.85 -0.35 3.57e-11 Daytime sleep phenotypes; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg21782813 chr7:2030301 MAD1L1 0.35 5.8 0.3 1.55e-8 Bipolar disorder and schizophrenia; LUSC cis rs6570726 0.818 rs398812 chr6:145817271 T/C cg05347473 chr6:146136440 FBXO30 0.44 7.53 0.38 4.7e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs17227506 0.606 rs6985004 chr8:13440282 G/C cg03566418 chr8:13424080 C8orf48 0.41 6.25 0.32 1.26e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs1949733 0.701 rs2631735 chr4:8476118 A/G cg11789530 chr4:8429930 ACOX3 0.56 8.46 0.42 8.25e-16 Response to antineoplastic agents; LUSC cis rs16910800 0.689 rs7101825 chr11:23164951 C/G cg20040320 chr11:23191996 NA 0.53 6.96 0.36 1.79e-11 Cancer; LUSC cis rs5769765 0.526 rs5770722 chr22:50253220 G/C cg22709217 chr22:50311962 ALG12;CRELD2 0.63 6.79 0.35 5e-11 Schizophrenia; LUSC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg13628971 chr7:2884303 GNA12 0.46 6.53 0.34 2.47e-10 Height; LUSC cis rs4851254 0.660 rs58683655 chr2:100686519 G/C cg22139774 chr2:100720529 AFF3 -0.43 -5.75 -0.3 1.99e-8 Intelligence (multi-trait analysis); LUSC cis rs2979489 0.891 rs4449748 chr8:30304402 A/G cg26383811 chr8:30366931 RBPMS 0.48 7.35 0.37 1.55e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs7590368 0.673 rs56264212 chr2:10931435 A/C cg15705551 chr2:10952987 PDIA6 0.52 5.86 0.31 1.13e-8 Educational attainment (years of education); LUSC cis rs9372253 1.000 rs7740028 chr6:110719180 A/G cg00083206 chr6:110721305 DDO -0.46 -8.29 -0.41 2.81e-15 Platelet distribution width; LUSC cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg00071950 chr4:10020882 SLC2A9 0.65 10.91 0.51 6.69e-24 Bone mineral density; LUSC cis rs2274273 0.934 rs10140869 chr14:55795283 G/A cg04306507 chr14:55594613 LGALS3 0.53 11.68 0.54 1.2e-26 Protein biomarker; LUSC cis rs9303401 0.659 rs12952325 chr17:56899371 G/A cg25039879 chr17:56429692 SUPT4H1 0.67 9.05 0.44 1.19e-17 Cognitive test performance; LUSC cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg25258033 chr6:167368657 RNASET2 0.39 6.37 0.33 6.15e-10 Crohn's disease; LUSC cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg08999081 chr20:33150536 PIGU 0.45 8.12 0.41 9.36e-15 Coronary artery disease; LUSC cis rs875971 0.830 rs12673450 chr7:66009220 G/A cg18252515 chr7:66147081 NA -0.45 -6.54 -0.34 2.34e-10 Aortic root size; LUSC trans rs4942242 0.640 rs17460861 chr13:44230078 C/G cg19169023 chr15:41853346 TYRO3 0.6 8.94 0.44 2.68e-17 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11229555 1.000 rs11229545 chr11:58386650 A/G cg15696309 chr11:58395628 NA -0.69 -9.27 -0.45 2.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs3960554 0.808 rs867973 chr7:75686007 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 9.49 0.46 4.38e-19 Eotaxin levels; LUSC cis rs59698941 0.527 rs7719428 chr5:132180919 C/G cg14825688 chr5:132208181 LEAP2 0.42 6.16 0.32 2.05e-9 Apolipoprotein A-IV levels; LUSC cis rs9399135 1.000 rs4896130 chr6:135355118 C/T cg24558204 chr6:135376177 HBS1L 0.59 8.98 0.44 2.02e-17 Red blood cell count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21736309 chr19:19774664 ATP13A1 -0.41 -5.99 -0.31 5.55e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7584330 0.737 rs7568588 chr2:238364342 G/T cg16989719 chr2:238392110 NA -0.41 -7.25 -0.37 3e-12 Prostate cancer; LUSC cis rs3862435 0.706 rs12595061 chr15:90974057 A/T cg22089800 chr15:90895588 ZNF774 0.58 6.33 0.33 8.01e-10 Response to exercise (triglyceride level interaction); LUSC cis rs3768617 0.706 rs11588675 chr1:182988052 C/T ch.1.3577855R chr1:183094577 LAMC1 0.58 8.31 0.41 2.37e-15 Fuchs's corneal dystrophy; LUSC cis rs36405 0.500 rs11621704 chr14:72355193 G/A cg23396177 chr14:72358413 NA -0.38 -7.04 -0.36 1.11e-11 Yang-deficiency constitution; LUSC cis rs7100689 0.646 rs1340374 chr10:82129114 C/T cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs9303401 0.659 rs11495824 chr17:56918882 C/A cg25039879 chr17:56429692 SUPT4H1 0.67 8.95 0.44 2.48e-17 Cognitive test performance; LUSC cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.62 0.43 2.64e-16 Menarche (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07750655 chr16:5121855 ALG1 -0.4 -6.02 -0.31 4.6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg04545296 chr12:48745243 ZNF641 0.37 6.68 0.34 1.01e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7020830 0.931 rs13295115 chr9:37157964 T/G cg14294708 chr9:37120828 ZCCHC7 1.13 25.27 0.81 1.56e-79 Schizophrenia; LUSC cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg27446573 chr6:127587934 RNF146 0.91 15.04 0.64 2.1e-39 Breast cancer; LUSC cis rs9400467 0.528 rs10872066 chr6:111593611 C/G cg22127309 chr6:111907043 TRAF3IP2 -0.35 -6.44 -0.33 4.07e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg00509249 chr6:109615579 CCDC162 -0.33 -5.9 -0.31 9.08e-9 Reticulocyte fraction of red cells; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04626574 chr22:26879726 HPS4;SRRD 0.47 6.21 0.32 1.58e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs1997103 1.000 rs6953509 chr7:55412179 G/A cg20935933 chr6:143382018 AIG1 0.51 7.43 0.38 8.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7824557 0.507 rs7010590 chr8:11062882 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.2 0.32 1.69e-9 Retinal vascular caliber; LUSC cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg16797656 chr11:68205561 LRP5 0.36 5.94 0.31 7.09e-9 Total body bone mineral density; LUSC cis rs36093844 0.799 rs7124956 chr11:85588819 A/G cg25872744 chr11:85566296 CCDC83 -0.42 -6.89 -0.35 2.76e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs2710642 0.540 rs12993804 chr2:63494689 T/A cg17519650 chr2:63277830 OTX1 -0.45 -6.13 -0.32 2.44e-9 LDL cholesterol levels;LDL cholesterol; LUSC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg20476274 chr7:133979776 SLC35B4 0.85 16.22 0.66 4.85e-44 Mean platelet volume; LUSC trans rs1941687 0.702 rs10460050 chr18:31413671 G/T cg27147174 chr7:100797783 AP1S1 -0.45 -6.76 -0.35 6.26e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg19539972 chr4:7069911 GRPEL1 0.67 8.68 0.43 1.76e-16 Monocyte percentage of white cells; LUSC cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg04450456 chr4:17643702 FAM184B -0.39 -6.38 -0.33 5.8e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3862030 0.720 rs11593971 chr10:104234090 C/G cg05855489 chr10:104503620 C10orf26 0.5 7.68 0.39 1.81e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg00409905 chr10:38381863 ZNF37A 0.37 6.24 0.32 1.33e-9 Extrinsic epigenetic age acceleration; LUSC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg09323728 chr8:95962352 TP53INP1 0.36 6.71 0.34 8.32e-11 Type 2 diabetes; LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs96067 0.805 rs7522400 chr1:36613380 A/G cg24686825 chr1:36642396 MAP7D1 -0.65 -9.08 -0.44 1e-17 Corneal structure; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg00929878 chr9:95087334 NOL8;CENPP 0.34 6.02 0.31 4.68e-9 Tuberculosis; LUSC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg14343924 chr8:8086146 FLJ10661 0.44 5.9 0.31 9.11e-9 Neuroticism; LUSC cis rs7586879 0.719 rs7565468 chr2:25130092 C/T cg01884057 chr2:25150051 NA 0.42 8.75 0.43 1.1e-16 Body mass index; LUSC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg20476274 chr7:133979776 SLC35B4 0.82 14.99 0.63 3.23e-39 Mean platelet volume; LUSC cis rs12410462 0.681 rs78978081 chr1:227571619 G/A cg10327440 chr1:227177885 CDC42BPA -0.62 -5.79 -0.3 1.59e-8 Major depressive disorder; LUSC cis rs6733011 0.500 rs885115 chr2:99446445 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.65 -0.34 1.18e-10 Bipolar disorder; LUSC cis rs7759001 0.857 rs4713088 chr6:27350626 C/T cg18711553 chr6:27366782 ZNF391 0.41 5.98 0.31 5.84e-9 Glomerular filtration rate (creatinine); LUSC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg18404041 chr3:52824283 ITIH1 -0.58 -9.62 -0.47 1.75e-19 Schizophrenia; LUSC cis rs9467711 0.606 rs2235251 chr6:26431982 C/T cg09904177 chr6:26538194 HMGN4 -0.74 -6.83 -0.35 4.11e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg13451222 chr11:65405525 SIPA1 0.43 5.66 0.3 3.31e-8 Blood pressure (age interaction); LUSC cis rs73200209 0.744 rs56187732 chr12:116688042 C/T cg01776926 chr12:116560359 MED13L -0.5 -6.07 -0.32 3.46e-9 Total body bone mineral density; LUSC cis rs7914558 0.621 rs10786722 chr10:104660068 C/T cg05855489 chr10:104503620 C10orf26 0.42 5.76 0.3 1.92e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg13319975 chr6:146136371 FBXO30 -0.38 -5.78 -0.3 1.71e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs73416724 1.000 rs79329802 chr6:43387332 G/A cg26312998 chr6:43337775 ZNF318 0.53 6.15 0.32 2.23e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7474896 0.515 rs2738208 chr10:38306128 A/G cg25427524 chr10:38739819 LOC399744 0.43 5.75 0.3 2e-8 Obesity (extreme); LUSC cis rs12594515 0.967 rs11070465 chr15:45984899 A/G cg19682013 chr15:45996608 NA 0.39 5.95 0.31 6.77e-9 Waist circumference;Weight; LUSC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.77e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg08917208 chr2:24149416 ATAD2B 0.56 6.35 0.33 7.14e-10 Lymphocyte counts; LUSC cis rs16976116 0.901 rs28499113 chr15:55503621 T/C cg11288833 chr15:55489084 RSL24D1 0.5 5.93 0.31 7.52e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15122365 chr12:51664392 SMAGP 0.81 6.47 0.33 3.55e-10 Cognitive performance; LUSC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg14196790 chr5:131705035 SLC22A5 0.51 8.82 0.43 6.65e-17 Blood metabolite levels; LUSC cis rs4969178 0.930 rs12452576 chr17:76386037 A/C cg05887092 chr17:76393375 PGS1 0.52 9.11 0.45 7.88e-18 HDL cholesterol levels; LUSC cis rs11190604 1.000 rs2495743 chr10:102329739 G/C cg07080220 chr10:102295463 HIF1AN 0.67 8.7 0.43 1.49e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg27432699 chr2:27873401 GPN1 -0.62 -9.74 -0.47 7e-20 Total body bone mineral density; LUSC cis rs7267979 1.000 rs2482919 chr20:25299756 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.52 -0.34 2.67e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg08499158 chr17:42289980 UBTF -0.46 -7.65 -0.39 2.13e-13 Total body bone mineral density; LUSC trans rs2243480 0.831 rs57294491 chr7:65684901 T/A cg10756647 chr7:56101905 PSPH -0.87 -8.67 -0.43 1.88e-16 Diabetic kidney disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01147013 chr3:45017855 ZDHHC3;EXOSC7 -0.42 -5.99 -0.31 5.52e-9 Electrocardiographic conduction measures; LUSC trans rs11722228 0.549 rs56146302 chr4:10081052 C/T cg26043149 chr18:55253948 FECH 0.96 14.36 0.62 9.24e-37 Gout;Urate levels;Serum uric acid levels; LUSC trans rs7739264 0.602 rs6925511 chr6:19773553 C/T cg13431028 chr2:169073609 STK39 -0.35 -5.99 -0.31 5.47e-9 Endometriosis; LUSC cis rs7568458 0.837 rs3731827 chr2:85806068 T/C cg17127132 chr2:85788382 GGCX 0.49 7.92 0.4 3.6e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg02772935 chr3:125709198 NA -0.48 -5.84 -0.3 1.23e-8 Blood pressure (smoking interaction); LUSC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.51 0.5 1.68e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.567 rs11191573 chr10:104896816 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs3760982 0.585 rs11673534 chr19:44298884 G/A cg11993925 chr19:44307056 LYPD5 0.36 7.86 0.4 5.35e-14 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs3768617 0.528 rs10737241 chr1:183098208 C/T ch.1.3577855R chr1:183094577 LAMC1 0.73 11.11 0.52 1.34e-24 Fuchs's corneal dystrophy; LUSC cis rs2732480 0.500 rs7315820 chr12:48598938 C/T cg04545296 chr12:48745243 ZNF641 0.33 6.06 0.31 3.63e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg23791538 chr6:167370224 RNASET2 -0.37 -5.86 -0.31 1.12e-8 Crohn's disease; LUSC cis rs7264396 0.635 rs6060696 chr20:34522060 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.02 -0.44 1.54e-17 Total cholesterol levels; LUSC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg03806693 chr22:41940476 POLR3H 0.88 12.77 0.57 1.06e-30 Vitiligo; LUSC cis rs7666738 0.546 rs34621463 chr4:98793357 G/C cg17366294 chr4:99064904 C4orf37 0.55 8.77 0.43 9.47e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg21573476 chr21:45109991 RRP1B -0.38 -6.32 -0.33 8.23e-10 Mean corpuscular volume; LUSC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.59e-29 Prudent dietary pattern; LUSC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg00071950 chr4:10020882 SLC2A9 0.58 9.96 0.48 1.27e-20 Bone mineral density; LUSC cis rs7903847 0.642 rs10786341 chr10:99158607 G/A cg08345082 chr10:99160200 RRP12 -0.35 -7.17 -0.37 4.75e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs8028313 0.630 rs8035989 chr15:67965620 G/A cg27219399 chr15:67835830 MAP2K5 0.35 5.7 0.3 2.63e-8 Obesity; LUSC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg16479474 chr6:28041457 NA -0.33 -5.91 -0.31 8.31e-9 Depression; LUSC trans rs9747201 1.000 rs36048409 chr17:80096961 T/A cg07393940 chr7:158741817 NA -0.51 -8.09 -0.4 1.12e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg16606324 chr3:10149918 C3orf24 0.6 8.55 0.42 4.59e-16 Alzheimer's disease; LUSC trans rs9329221 1.000 rs9329221 chr8:10240202 G/T cg08975724 chr8:8085496 FLJ10661 0.41 6.0 0.31 5.2e-9 Neuroticism; LUSC cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg11057378 chr10:81107060 PPIF -0.38 -6.53 -0.34 2.51e-10 Height; LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.55 0.6 1.23e-33 Platelet count; LUSC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg09323728 chr8:95962352 TP53INP1 0.38 7.83 0.39 6.56e-14 Type 2 diabetes; LUSC trans rs2797160 0.935 rs926855 chr6:126021782 A/G cg05039488 chr6:79577232 IRAK1BP1 0.45 6.88 0.35 2.92e-11 Endometrial cancer; LUSC cis rs7674212 0.531 rs6816370 chr4:103939433 C/T cg16532752 chr4:104119610 CENPE -0.43 -6.02 -0.31 4.5e-9 Type 2 diabetes; LUSC cis rs4841097 0.876 rs6601288 chr8:8943430 A/T cg15556689 chr8:8085844 FLJ10661 0.41 6.03 0.31 4.23e-9 Platelet distribution width; LUSC cis rs1577917 0.958 rs28442244 chr6:86701236 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.44 6.35 0.33 7.16e-10 Response to antipsychotic treatment; LUSC cis rs6087990 0.735 rs1003522 chr20:31368560 T/C cg13636640 chr20:31349939 DNMT3B 0.91 18.52 0.71 3.6e-53 Ulcerative colitis; LUSC cis rs7615316 1.000 rs1983434 chr3:142347757 A/G cg16271453 chr3:142027066 XRN1 -0.34 -5.82 -0.3 1.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2289583 0.503 rs12050494 chr15:75260896 G/A cg14664628 chr15:75095509 CSK 0.46 6.19 0.32 1.75e-9 Systemic lupus erythematosus; LUSC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg00677455 chr12:58241039 CTDSP2 0.61 8.47 0.42 7.68e-16 Multiple sclerosis; LUSC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg04025307 chr7:1156635 C7orf50 0.43 5.98 0.31 5.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1506636 1.000 rs2402669 chr7:123297460 C/G cg03229431 chr7:123269106 ASB15 -0.65 -10.61 -0.5 7.56e-23 Plateletcrit;Platelet count; LUSC cis rs4363385 0.747 rs2339494 chr1:152975143 G/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.67 -0.39 1.85e-13 Inflammatory skin disease; LUSC cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg11266682 chr4:10021025 SLC2A9 -0.51 -9.37 -0.46 1.15e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg27494647 chr7:150038898 RARRES2 0.52 7.97 0.4 2.5e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7584330 0.554 rs112402109 chr2:238429058 A/G cg16989719 chr2:238392110 NA -0.44 -6.14 -0.32 2.33e-9 Prostate cancer; LUSC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg25072359 chr17:41440525 NA 0.65 9.46 0.46 5.86e-19 Menopause (age at onset); LUSC cis rs9612 0.718 rs346535 chr19:44251425 C/T cg08581076 chr19:44259116 C19orf61 0.49 6.29 0.33 9.86e-10 Exhaled nitric oxide output; LUSC cis rs12586317 0.620 rs8020370 chr14:35581432 G/A cg16230307 chr14:35515116 FAM177A1 0.77 10.03 0.48 7.02e-21 Psoriasis; LUSC cis rs1267303 0.675 rs1267308 chr1:46987718 A/G cg25110126 chr1:46999211 NA -0.6 -7.94 -0.4 3.1e-14 Monobrow; LUSC cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.65 8.48 0.42 7.52e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4499344 0.696 rs10402929 chr19:33100245 C/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg05425664 chr17:57184151 TRIM37 -0.57 -8.42 -0.42 1.13e-15 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg13685833 chr1:53393034 SCP2 -0.38 -5.74 -0.3 2.08e-8 Monocyte count; LUSC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.66 0.34 1.12e-10 Systemic lupus erythematosus; LUSC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg22800045 chr5:56110881 MAP3K1 0.77 9.85 0.47 2.96e-20 Initial pursuit acceleration; LUSC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.91 0.31 8.46e-9 Menopause (age at onset); LUSC trans rs1005277 0.505 rs200931 chr10:38128434 A/C cg17830980 chr10:43048298 ZNF37B -0.43 -6.61 -0.34 1.49e-10 Extrinsic epigenetic age acceleration; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.71 11.94 0.55 1.36e-27 Prudent dietary pattern; LUSC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg24060327 chr5:131705240 SLC22A5 -0.42 -6.65 -0.34 1.18e-10 Blood metabolite levels; LUSC cis rs8028313 0.731 rs11857017 chr15:67972908 A/G cg08079166 chr15:68083412 MAP2K5 0.36 6.23 0.32 1.39e-9 Obesity; LUSC trans rs6089829 0.962 rs2314130 chr20:61665129 G/T cg17470723 chr8:74884337 TCEB1 0.52 8.21 0.41 4.83e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.46 -6.37 -0.33 6.15e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12681287 0.752 rs9297861 chr8:87254730 G/C cg27223183 chr8:87520930 FAM82B -0.45 -5.72 -0.3 2.33e-8 Caudate activity during reward; LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.79 0.65 2.34e-42 Platelet count; LUSC cis rs17621444 0.522 rs10886570 chr10:121786379 G/T cg02041677 chr10:121771263 NA -0.35 -6.39 -0.33 5.62e-10 IgG glycosylation; LUSC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg18479299 chr3:125709523 NA -0.5 -5.7 -0.3 2.68e-8 Blood pressure (smoking interaction); LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg10862848 chr6:42927986 GNMT -0.28 -6.57 -0.34 1.91e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg14121845 chr20:25566513 NINL 0.31 5.66 0.3 3.21e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg09491104 chr22:46646882 C22orf40 0.7 9.07 0.44 1.03e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.31 0.41 2.42e-15 Melanoma; LUSC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg12639453 chr1:2035780 PRKCZ -0.3 -6.41 -0.33 4.91e-10 Height; LUSC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg20821713 chr7:1055600 C7orf50 0.5 6.63 0.34 1.38e-10 Bronchopulmonary dysplasia; LUSC cis rs829883 0.714 rs249847 chr12:98867716 C/T cg25150519 chr12:98850993 NA 0.8 14.01 0.61 2.21e-35 Colorectal adenoma (advanced); LUSC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg21963583 chr11:68658836 MRPL21 0.56 8.57 0.42 3.8e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg02782426 chr3:40428986 ENTPD3 0.33 6.22 0.32 1.47e-9 Renal cell carcinoma; LUSC trans rs1864729 1.000 rs1835743 chr8:98282643 T/C cg08679828 chr8:102218111 ZNF706 -0.87 -7.9 -0.4 3.95e-14 Estradiol plasma levels (breast cancer); LUSC cis rs7098414 0.511 rs10466236 chr10:82149717 C/T cg00277334 chr10:82204260 NA 0.54 8.85 0.44 5.02e-17 Post bronchodilator FEV1; LUSC cis rs6469656 1.000 rs13277714 chr8:117791528 A/G cg24004040 chr8:117650383 NA 0.41 5.79 0.3 1.63e-8 Colorectal cancer; LUSC cis rs13253111 0.967 rs11136036 chr8:28061310 C/T cg26534493 chr8:28060551 NA 0.46 8.64 0.43 2.36e-16 Childhood body mass index; LUSC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg21573476 chr21:45109991 RRP1B -0.4 -6.47 -0.33 3.41e-10 Mean corpuscular volume; LUSC cis rs7937682 0.889 rs7926485 chr11:111536670 G/A cg22437258 chr11:111473054 SIK2 0.5 6.82 0.35 4.3e-11 Primary sclerosing cholangitis; LUSC cis rs983392 0.667 rs632185 chr11:59951433 A/G cg24026212 chr11:59952134 MS4A6A 0.34 6.15 0.32 2.22e-9 Alzheimer's disease (late onset); LUSC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg19257562 chr1:2043853 PRKCZ 0.33 6.65 0.34 1.21e-10 Height; LUSC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg17279839 chr7:150038598 RARRES2 0.48 7.6 0.38 3.05e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs983392 0.709 rs11601689 chr11:59996266 G/C cg24026212 chr11:59952134 MS4A6A -0.35 -6.05 -0.31 3.78e-9 Alzheimer's disease (late onset); LUSC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg11494091 chr17:61959527 GH2 0.38 6.71 0.34 8.54e-11 Height; LUSC cis rs7659604 1.000 rs73844281 chr4:122664688 A/G cg05802129 chr4:122689817 NA -0.37 -6.69 -0.34 9.68e-11 Type 2 diabetes; LUSC cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg01028140 chr2:1542097 TPO -0.6 -7.98 -0.4 2.45e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg24692254 chr21:30365293 RNF160 0.92 18.14 0.7 1.15e-51 Dental caries; LUSC cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.41 6.37 0.33 6.29e-10 Rheumatoid arthritis; LUSC cis rs3849570 0.643 rs11705789 chr3:81969196 G/T cg07356753 chr3:81810745 GBE1 -0.54 -8.0 -0.4 2.1e-14 Waist circumference;Body mass index; LUSC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg07828024 chr6:149772892 ZC3H12D 0.35 7.6 0.38 2.97e-13 Dupuytren's disease; LUSC cis rs17270561 0.609 rs9393662 chr6:25739670 T/C cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC cis rs735539 1.000 rs2290143 chr13:21280363 A/G cg04906043 chr13:21280425 IL17D 0.45 8.6 0.43 3.04e-16 Dental caries; LUSC cis rs13385 0.769 rs9042 chr5:139625347 A/C cg26211634 chr5:139558579 C5orf32 0.45 6.59 0.34 1.75e-10 Atrial fibrillation; LUSC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.18 0.52 7.13e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6696846 0.715 rs12139373 chr1:205054879 A/C cg21545522 chr1:205238299 TMCC2 0.46 8.58 0.42 3.7e-16 Red blood cell count; LUSC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.3 0.41 2.56e-15 Axial length; LUSC cis rs1865760 1.000 rs9358893 chr6:25921761 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.82 0.35 4.38e-11 Height; LUSC cis rs1784581 0.569 rs9364629 chr6:162416831 T/G cg17173639 chr6:162384350 PARK2 0.57 9.94 0.48 1.44e-20 Itch intensity from mosquito bite; LUSC trans rs804280 0.560 rs10503426 chr8:11589383 A/C cg06636001 chr8:8085503 FLJ10661 0.54 7.79 0.39 8.64e-14 Myopia (pathological); LUSC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg13647721 chr17:30228624 UTP6 0.58 5.66 0.3 3.23e-8 Hip circumference adjusted for BMI; LUSC cis rs3755132 0.929 rs3213793 chr2:15744123 T/G cg12888861 chr2:15731646 DDX1 0.5 7.3 0.37 2.16e-12 Wilms tumor; LUSC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1864400 0.645 rs2249005 chr10:43627280 A/G cg02780029 chr10:43622663 RET -0.34 -5.7 -0.3 2.68e-8 Hirschsprung disease; LUSC cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg06636551 chr8:101224915 SPAG1 0.54 10.65 0.5 5.55e-23 Atrioventricular conduction; LUSC cis rs10191773 0.589 rs72833410 chr2:113054119 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.64 -7.91 -0.4 3.91e-14 Yeast infection; LUSC trans rs11148252 0.624 rs6561682 chr13:53266297 A/G cg18335740 chr13:41363409 SLC25A15 -0.51 -7.32 -0.37 1.89e-12 Lewy body disease; LUSC trans rs17685 0.712 rs1637049 chr7:75729975 C/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.69 0.73 7.88e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.46 8.02 0.4 1.8e-14 Axial length; LUSC cis rs3733418 0.799 rs13151735 chr4:165932516 G/C cg11630554 chr4:165878136 TRIM61;C4orf39 -0.48 -5.65 -0.3 3.46e-8 Obesity-related traits; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.68 10.44 0.5 2.84e-22 Lymphocyte counts; LUSC cis rs9814567 1.000 rs1880377 chr3:134270468 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg05868516 chr6:26286170 HIST1H4H 0.36 5.99 0.31 5.35e-9 Educational attainment; LUSC cis rs73206853 0.841 rs56130410 chr12:110824112 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 6.43 0.33 4.37e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg05347473 chr6:146136440 FBXO30 0.48 7.9 0.4 4.04e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.29 0.37 2.2e-12 Motion sickness; LUSC cis rs7095944 0.614 rs1055256 chr10:126446592 A/G cg08799069 chr10:126477246 METTL10 -0.42 -6.52 -0.34 2.53e-10 Asthma; LUSC cis rs4363385 0.720 rs883810 chr1:152941345 T/C cg07796016 chr1:152779584 LCE1C -0.4 -5.69 -0.3 2.78e-8 Inflammatory skin disease; LUSC cis rs3540 0.597 rs4932346 chr15:91048991 T/C cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.75 -0.3 1.97e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs1997103 0.911 rs6949931 chr7:55391081 T/C cg17469321 chr7:55412551 NA 0.68 10.76 0.51 2.16e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg18132916 chr6:79620363 NA -0.38 -5.69 -0.3 2.82e-8 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg27539214 chr16:67997921 SLC12A4 0.58 7.02 0.36 1.24e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs1467026 0.719 rs17037220 chr3:12818103 A/G cg24848339 chr3:12840334 CAND2 0.36 7.92 0.4 3.52e-14 P wave duration; LUSC cis rs7914558 0.966 rs12571568 chr10:104891396 C/G cg04362960 chr10:104952993 NT5C2 0.6 9.53 0.46 3.28e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs9329221 0.905 rs28507213 chr8:10250849 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.86 -0.4 5.24e-14 Neuroticism; LUSC cis rs1371867 0.875 rs1788169 chr8:101326314 C/T cg06636551 chr8:101224915 SPAG1 -0.45 -8.17 -0.41 6.22e-15 Atrioventricular conduction; LUSC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.54 7.5 0.38 5.77e-13 Multiple sclerosis; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg07677032 chr17:61819896 STRADA 0.52 8.61 0.43 2.91e-16 Prudent dietary pattern; LUSC cis rs4820539 1.000 rs5751589 chr22:23475762 A/G cg21100191 chr22:23484243 RTDR1 -0.93 -16.16 -0.66 8.65e-44 Bone mineral density; LUSC cis rs9790314 1.000 rs7653361 chr3:160992291 C/T cg04691961 chr3:161091175 C3orf57 -0.34 -5.81 -0.3 1.49e-8 Morning vs. evening chronotype; LUSC cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg03477792 chr4:77819574 ANKRD56 0.62 8.76 0.43 9.75e-17 Emphysema distribution in smoking; LUSC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg14552801 chr7:65878734 NA 0.36 5.66 0.3 3.23e-8 Aortic root size; LUSC cis rs7681440 0.904 rs28750169 chr4:90774303 A/G cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.26e-8 Dementia with Lewy bodies; LUSC cis rs7296418 0.699 rs11057219 chr12:123750073 T/C cg00376283 chr12:123451042 ABCB9 0.72 11.05 0.52 2.03e-24 Platelet count; LUSC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11644478 chr21:40555479 PSMG1 0.94 18.71 0.72 5.98e-54 Cognitive function; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.49 -6.51 -0.34 2.69e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2481665 0.680 rs2481671 chr1:62611666 A/C cg18591186 chr1:62594603 INADL -0.45 -7.23 -0.37 3.27e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7674212 0.540 rs2711897 chr4:104023567 C/T cg16532752 chr4:104119610 CENPE -0.49 -6.92 -0.35 2.35e-11 Type 2 diabetes; LUSC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 7.24 0.37 3.18e-12 Hip circumference adjusted for BMI; LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg13047869 chr3:10149882 C3orf24 0.63 8.73 0.43 1.21e-16 Alzheimer's disease; LUSC cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC trans rs1422110 0.616 rs6452689 chr5:85445059 A/T cg01787110 chr1:109008453 NBPF6 0.53 9.08 0.44 9.9e-18 Attention function in attention deficit hyperactive disorder; LUSC cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg04990556 chr1:26633338 UBXN11 -0.8 -14.87 -0.63 9.73e-39 Obesity-related traits; LUSC cis rs11098499 0.604 rs17051352 chr4:120581427 G/A cg09307838 chr4:120376055 NA 0.7 9.64 0.47 1.49e-19 Corneal astigmatism; LUSC cis rs2200578 1.000 rs12053519 chr2:99875018 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 0.61 7.16 0.36 5.11e-12 IgG glycosylation; LUSC trans rs17536732 0.688 rs1440602 chr4:162816315 C/G cg25554740 chr10:135047333 NA -0.41 -6.04 -0.31 4.08e-9 Risky sexual behaviors (alcohol dependence interaction); LUSC cis rs2540226 0.569 rs6722306 chr2:40052970 A/G cg23576258 chr2:39999331 THUMPD2 0.35 5.68 0.3 2.89e-8 Personality dimensions; LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04260516 chr14:24630327 IRF9 0.45 6.37 0.33 6.42e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9926296 0.632 rs4785716 chr16:89801127 T/C cg01097406 chr16:89675127 NA -0.34 -6.65 -0.34 1.2e-10 Vitiligo; LUSC cis rs4466137 0.553 rs16898 chr5:82986149 T/C cg16102102 chr5:83017553 HAPLN1 -0.69 -11.33 -0.53 2.06e-25 Prostate cancer; LUSC cis rs11608355 0.960 rs3742021 chr12:109883117 T/C cg19025524 chr12:109796872 NA -0.36 -5.71 -0.3 2.53e-8 Neuroticism; LUSC cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.53 0.38 4.76e-13 Colorectal cancer; LUSC cis rs9326248 0.861 rs4938353 chr11:117046197 G/A cg16524733 chr11:117070046 TAGLN 0.36 5.87 0.31 1.04e-8 Blood protein levels; LUSC cis rs5770917 1.000 rs2073604 chr22:51008925 G/A cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.64 -5.85 -0.3 1.18e-8 Narcolepsy; LUSC cis rs2180341 0.538 rs11556354 chr6:127664661 G/A cg24812749 chr6:127587940 RNF146 0.51 7.56 0.38 3.92e-13 Breast cancer; LUSC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg17985854 chr11:65770987 BANF1;EIF1AD -0.35 -5.92 -0.31 7.96e-9 Breast cancer; LUSC cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg20701182 chr2:24300061 SF3B14 0.88 11.49 0.53 5.5e-26 Lymphocyte counts; LUSC cis rs11098499 0.955 rs1511019 chr4:120166007 T/G cg24375607 chr4:120327624 NA 0.75 11.04 0.52 2.24e-24 Corneal astigmatism; LUSC cis rs11018904 0.636 rs61903695 chr11:89922417 A/G cg26138821 chr11:89956704 CHORDC1 -0.58 -7.47 -0.38 7.11e-13 Intelligence (multi-trait analysis); LUSC cis rs17255340 0.581 rs1144187 chr6:83986196 T/C cg08257003 chr6:84140564 ME1 0.31 7.54 0.38 4.4e-13 Platelet-derived growth factor BB levels; LUSC trans rs6089829 0.962 rs6089824 chr20:61659207 A/G cg23505145 chr19:12996616 KLF1 0.64 10.29 0.49 9.57e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.86 0.75 1.91e-62 Cognitive ability; LUSC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg11663144 chr21:46675770 NA -0.36 -5.76 -0.3 1.89e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs17641971 1.000 rs73579339 chr8:49888184 G/A cg15678142 chr1:167411538 CD247 0.42 5.97 0.31 6.09e-9 Blood metabolite levels; LUSC cis rs3916 0.794 rs10431384 chr12:121127347 C/T cg21892295 chr12:121157589 UNC119B 0.36 5.97 0.31 6.23e-9 Urinary metabolites (H-NMR features); LUSC cis rs1348850 0.526 rs2218575 chr2:178368997 C/A cg22681709 chr2:178499509 PDE11A -0.47 -6.88 -0.35 2.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg13560548 chr3:10150139 C3orf24 0.49 6.86 0.35 3.38e-11 Alzheimer's disease; LUSC cis rs3812762 0.917 rs905289 chr11:8753552 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.38 6.43 0.33 4.44e-10 Hypospadias; LUSC cis rs8040855 0.599 rs6496795 chr15:85725853 G/T cg04831495 chr15:85060580 GOLGA6L5 0.41 6.87 0.35 3.1e-11 Bulimia nervosa; LUSC cis rs7100689 0.577 rs1143694 chr10:82040052 C/T cg01528321 chr10:82214614 TSPAN14 -0.92 -14.49 -0.62 2.87e-37 Post bronchodilator FEV1; LUSC cis rs7937682 0.924 rs10891288 chr11:111552053 G/T cg09085632 chr11:111637200 PPP2R1B 1.06 16.42 0.67 7.52e-45 Primary sclerosing cholangitis; LUSC cis rs4948275 0.550 rs10994742 chr10:63132240 A/T cg03237606 chr10:63212265 TMEM26 -0.39 -5.94 -0.31 7.2e-9 Night sleep phenotypes; LUSC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.66 15.01 0.63 2.89e-39 Hemoglobin concentration; LUSC cis rs1570884 0.536 rs1359541 chr13:50158939 A/G cg08779649 chr13:50194554 NA 0.37 6.22 0.32 1.49e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs7267979 1.000 rs6050630 chr20:25430745 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg06671706 chr8:8559999 CLDN23 0.48 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs2361718 0.527 rs7211994 chr17:78152514 A/G cg06718696 chr17:78121285 EIF4A3 -0.45 -6.5 -0.34 2.87e-10 Yeast infection; LUSC cis rs13315871 1.000 rs11713214 chr3:58445991 C/T cg20936604 chr3:58311152 NA -0.72 -6.77 -0.35 5.83e-11 Cholesterol, total; LUSC cis rs2290159 0.800 rs9849807 chr3:12675026 A/G cg23032965 chr3:12705835 RAF1 0.74 9.13 0.45 6.87e-18 Cholesterol, total; LUSC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg14019146 chr3:50243930 SLC38A3 0.32 7.11 0.36 7.17e-12 Intelligence (multi-trait analysis); LUSC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg23283495 chr1:209979779 IRF6 0.67 8.71 0.43 1.48e-16 Cleft lip with or without cleft palate; LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.88 0.63 8.88e-39 Platelet count; LUSC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg23630131 chr7:65973040 NA -0.22 -6.03 -0.31 4.35e-9 Aortic root size; LUSC cis rs738322 0.555 rs5756932 chr22:38546118 C/T cg25457927 chr22:38595422 NA -0.41 -8.25 -0.41 3.7e-15 Cutaneous nevi; LUSC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg07700843 chr1:2391317 NA -0.46 -7.02 -0.36 1.28e-11 Non-obstructive azoospermia; LUSC cis rs2295359 0.892 rs72676069 chr1:67658954 T/C cg17031739 chr1:67600172 NA 0.45 6.91 0.35 2.43e-11 Psoriasis; LUSC cis rs9434723 0.844 rs2239561 chr1:9304205 C/T cg04199779 chr1:9294473 H6PD -0.5 -5.86 -0.31 1.08e-8 Height; LUSC cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.93 17.13 0.68 1.22e-47 Body mass index (adult); LUSC cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg16230307 chr14:35515116 FAM177A1 0.74 8.78 0.43 8.74e-17 Psoriasis; LUSC cis rs6754311 0.513 rs1438304 chr2:136503157 A/G cg07169764 chr2:136633963 MCM6 -0.6 -7.95 -0.4 2.88e-14 Mosquito bite size; LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17818399 0.735 rs11894342 chr2:46836439 A/T cg02822958 chr2:46747628 ATP6V1E2 0.34 5.78 0.3 1.71e-8 Height; LUSC cis rs6754311 0.517 rs1469995 chr2:136542559 G/A cg07169764 chr2:136633963 MCM6 0.87 11.94 0.55 1.28e-27 Mosquito bite size; LUSC cis rs6835098 0.923 rs7671278 chr4:174095769 A/G cg08422745 chr4:174089978 GALNT7 -0.82 -13.45 -0.59 2.9e-33 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg23172400 chr8:95962367 TP53INP1 -0.37 -7.6 -0.38 2.93e-13 Type 2 diabetes; LUSC cis rs7666738 0.716 rs6814353 chr4:99074202 A/G cg03676636 chr4:99064102 C4orf37 0.32 6.89 0.35 2.77e-11 Colonoscopy-negative controls vs population controls; LUSC trans rs7824557 0.564 rs11782430 chr8:11226071 A/G cg15556689 chr8:8085844 FLJ10661 -0.59 -8.81 -0.43 6.71e-17 Retinal vascular caliber; LUSC cis rs240764 0.658 rs35168784 chr6:101183499 C/T cg09795085 chr6:101329169 ASCC3 -0.45 -6.65 -0.34 1.21e-10 Neuroticism; LUSC cis rs17401966 0.624 rs6696978 chr1:10209557 C/T cg19773385 chr1:10388646 KIF1B 0.42 6.21 0.32 1.54e-9 Hepatocellular carcinoma; LUSC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg19812747 chr11:111475976 SIK2 -0.55 -8.18 -0.41 5.92e-15 Primary sclerosing cholangitis; LUSC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 7.37 0.37 1.38e-12 Cerebrospinal P-tau181p levels; LUSC cis rs1113500 0.897 rs55980437 chr1:108639498 G/A cg11967332 chr1:108735228 SLC25A24 0.39 5.94 0.31 7.31e-9 Growth-regulated protein alpha levels; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg13126279 chr21:47581558 C21orf56 0.47 7.05 0.36 1e-11 Testicular germ cell tumor; LUSC cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.82 0.43 6.31e-17 Menopause (age at onset); LUSC cis rs9649213 0.614 rs62479858 chr7:97924226 C/T cg08684580 chr7:98029266 BAIAP2L1 0.39 5.98 0.31 5.66e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs478304 0.651 rs11604462 chr11:65551648 G/A cg10518572 chr11:65560635 OVOL1 -0.27 -6.0 -0.31 5.24e-9 Acne (severe); LUSC cis rs4594175 0.926 rs10145287 chr14:51626808 G/T cg23942311 chr14:51606299 NA 0.31 5.78 0.3 1.73e-8 Cancer; LUSC trans rs72674100 1.000 rs72874654 chr4:97966415 A/G cg16405019 chr1:18959625 PAX7 -0.64 -6.78 -0.35 5.33e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9300255 0.602 rs6488864 chr12:123618362 G/C cg00376283 chr12:123451042 ABCB9 0.69 7.76 0.39 1.07e-13 Neutrophil percentage of white cells; LUSC cis rs6942756 0.806 rs7794622 chr7:128996268 T/C cg02491457 chr7:128862824 NA -0.5 -7.29 -0.37 2.2e-12 White matter hyperintensity burden; LUSC cis rs76878669 0.538 rs1546358 chr11:66175261 G/C cg24851651 chr11:66362959 CCS -0.39 -6.14 -0.32 2.37e-9 Educational attainment (years of education); LUSC cis rs28374715 0.681 rs7165396 chr15:41586947 T/C cg18705301 chr15:41695430 NDUFAF1 -1.02 -21.22 -0.76 7.29e-64 Ulcerative colitis; LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1728785 1.000 rs1645976 chr16:68563509 T/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC trans rs10435719 0.899 rs9329251 chr8:11793606 G/A cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.2e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs74181299 1.000 rs74181299 chr2:65283972 T/C cg05010058 chr2:65284262 CEP68 0.31 6.11 0.32 2.73e-9 Pulse pressure; LUSC cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC trans rs4332037 0.539 rs1533827 chr7:2074290 A/G cg11693508 chr17:37793320 STARD3 -0.52 -6.31 -0.33 9.01e-10 Bipolar disorder; LUSC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg06008330 chr7:65541103 ASL -0.4 -6.24 -0.32 1.36e-9 Aortic root size; LUSC cis rs9287719 0.967 rs10203785 chr2:10752508 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.88e-9 Prostate cancer; LUSC cis rs2742234 0.666 rs715106 chr10:43616751 C/A cg15436174 chr10:43711423 RASGEF1A -0.45 -7.33 -0.37 1.71e-12 Hirschsprung disease; LUSC cis rs926938 0.584 rs2798663 chr1:115363582 G/A cg12756093 chr1:115239321 AMPD1 0.53 7.92 0.4 3.61e-14 Autism; LUSC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.99 0.4 2.22e-14 Bipolar disorder; LUSC cis rs354225 0.626 rs7591204 chr2:54829458 C/G cg01766943 chr2:54829624 SPTBN1 -0.49 -7.63 -0.39 2.4e-13 Schizophrenia; LUSC cis rs7264396 0.790 rs6060539 chr20:34239382 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.82 -0.47 3.7e-20 Total cholesterol levels; LUSC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4906332 1.000 rs8012623 chr14:103937086 G/A cg04998671 chr14:104000505 TRMT61A -0.45 -7.15 -0.36 5.46e-12 Coronary artery disease; LUSC cis rs11098499 0.863 rs2306457 chr4:120472839 T/A cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs4595586 0.545 rs1156707 chr12:39372451 G/T cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.08e-9 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.0 0.52 3.28e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs9650315 0.641 rs67781593 chr8:57187632 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.45 0.38 7.92e-13 Height; LUSC trans rs12210905 0.688 rs12194842 chr6:27367978 A/C cg14616345 chr9:133901267 LAMC3 -0.65 -5.95 -0.31 6.6e-9 Hip circumference adjusted for BMI; LUSC cis rs4930103 1.000 rs4930103 chr11:2024544 G/A cg23202291 chr11:1979235 NA 0.39 6.07 0.32 3.52e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg17211192 chr8:82754475 SNX16 -0.82 -11.22 -0.52 5.21e-25 Diastolic blood pressure; LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.92e-21 Monocyte count; LUSC cis rs28830936 1.000 rs9672298 chr15:41912368 A/C cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.32 -0.33 8.25e-10 Diastolic blood pressure; LUSC cis rs9648716 0.515 rs57725920 chr7:140428350 A/T cg23214464 chr7:140373596 ADCK2 0.72 5.87 0.31 1.02e-8 Type 2 diabetes; LUSC cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg13010199 chr12:38710504 ALG10B 0.7 10.75 0.51 2.33e-23 Bladder cancer; LUSC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg13683864 chr3:40499215 RPL14 -1.13 -21.22 -0.76 6.9e-64 Renal cell carcinoma; LUSC cis rs968451 1.000 rs57078777 chr22:39697458 A/T cg17798944 chr22:39715225 SNORD43;RPL3 0.68 9.0 0.44 1.8e-17 Primary biliary cholangitis; LUSC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.48 -0.38 6.47e-13 Height; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg05552183 chr6:42928497 GNMT -0.53 -8.86 -0.44 4.95e-17 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg14004847 chr7:1930337 MAD1L1 -0.48 -7.14 -0.36 6.03e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs17807624 0.780 rs13277929 chr8:11453030 G/A cg21175976 chr8:11421337 BLK 0.37 6.11 0.32 2.8e-9 Systemic lupus erythematosus; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg25971741 chr6:15343116 JARID2 -0.39 -6.28 -0.32 1.03e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.65 11.3 0.53 2.64e-25 Menopause (age at onset); LUSC cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.65 0.3 3.39e-8 Schizophrenia; LUSC cis rs9905704 0.647 rs12943705 chr17:57097047 T/C cg05425664 chr17:57184151 TRIM37 0.49 7.41 0.38 1.06e-12 Testicular germ cell tumor; LUSC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg11764359 chr7:65958608 NA -0.69 -10.89 -0.51 7.82e-24 Aortic root size; LUSC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg24450063 chr1:156163899 SLC25A44 1.2 31.07 0.86 1.56e-100 Testicular germ cell tumor; LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.12 -0.48 3.44e-21 Obesity-related traits; LUSC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.24 0.45 2.91e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg24110177 chr3:50126178 RBM5 -0.55 -9.17 -0.45 4.97e-18 Intelligence (multi-trait analysis); LUSC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg11812906 chr14:75593930 NEK9 -0.62 -10.7 -0.51 3.72e-23 Height; LUSC cis rs908922 0.885 rs2181173 chr1:152474866 A/T cg20991723 chr1:152506922 NA -0.51 -9.3 -0.45 1.87e-18 Hair morphology; LUSC trans rs11039798 1.000 rs115429994 chr11:48761183 C/G cg15704280 chr7:45808275 SEPT13 0.81 7.73 0.39 1.27e-13 Axial length; LUSC cis rs977987 0.872 rs3743609 chr16:75467021 G/C cg03315344 chr16:75512273 CHST6 0.54 10.28 0.49 9.87e-22 Dupuytren's disease; LUSC cis rs11098499 0.645 rs78422072 chr4:120281042 C/T cg09307838 chr4:120376055 NA 0.69 10.03 0.48 7.01e-21 Corneal astigmatism; LUSC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg16479474 chr6:28041457 NA 0.32 5.7 0.3 2.6e-8 Depression; LUSC cis rs11158026 0.603 rs12147796 chr14:55408696 C/T cg04306507 chr14:55594613 LGALS3 0.37 6.52 0.34 2.67e-10 Parkinson's disease; LUSC cis rs7618501 1.000 rs7618501 chr3:49772647 A/G cg24110177 chr3:50126178 RBM5 0.42 6.73 0.35 7.18e-11 Intelligence (multi-trait analysis); LUSC cis rs7131987 0.903 rs6487796 chr12:29422764 A/G cg09582351 chr12:29534625 ERGIC2 -0.32 -6.69 -0.34 9.62e-11 QT interval; LUSC cis rs2279817 0.820 rs11203440 chr1:18026352 A/G cg21791023 chr1:18019539 ARHGEF10L 0.43 5.91 0.31 8.27e-9 Neuroticism; LUSC cis rs17828380 0.920 rs7177131 chr15:63443189 C/T cg05507819 chr15:63340323 TPM1 -0.78 -5.91 -0.31 8.37e-9 Social communication problems; LUSC cis rs11711311 0.955 rs67550112 chr3:113401988 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.83 0.3 1.32e-8 IgG glycosylation; LUSC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs67072384 0.892 rs67034709 chr11:72451004 T/C cg04827223 chr11:72435913 ARAP1 -0.81 -7.3 -0.37 2.13e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs28647808 0.881 rs4246171 chr9:136264731 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.92 -0.35 2.29e-11 Lung cancer; LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.48 -0.33 3.3e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg02153584 chr22:29168773 CCDC117 -0.57 -8.48 -0.42 7.17e-16 Lymphocyte counts; LUSC trans rs17685 0.712 rs10952842 chr7:75780413 G/A cg19862616 chr7:65841803 NCRNA00174 1.12 18.97 0.72 5.86e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6831352 0.765 rs35361391 chr4:100069281 A/T cg13256891 chr4:100009986 ADH5 -0.5 -6.47 -0.33 3.53e-10 Alcohol dependence; LUSC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.9e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg11062466 chr8:58055876 NA 0.44 5.79 0.3 1.61e-8 Developmental language disorder (linguistic errors); LUSC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg06108461 chr20:60628389 TAF4 -1.0 -16.59 -0.67 1.63e-45 Body mass index; LUSC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs853679 0.546 rs200953 chr6:27837267 T/C cg01620082 chr3:125678407 NA -0.69 -7.03 -0.36 1.19e-11 Depression; LUSC cis rs1670533 0.932 rs13106586 chr4:1054182 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.08 0.32 3.24e-9 Recombination rate (females); LUSC cis rs9309473 1.000 rs7586463 chr2:73798476 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.53 -0.34 2.47e-10 Metabolite levels; LUSC cis rs1355223 0.583 rs1549789 chr11:34867947 G/A cg11058730 chr11:34937778 PDHX;APIP 0.67 10.84 0.51 1.18e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.2 0.52 5.97e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10992471 0.603 rs7868013 chr9:95240173 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.68 -0.39 1.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1413885 0.548 rs6588136 chr1:65837119 C/G cg14976592 chr1:65886160 LEPROT;LEPR 0.49 7.18 0.37 4.41e-12 Anticoagulant levels; LUSC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg04287289 chr16:89883240 FANCA 0.6 8.77 0.43 8.99e-17 Vitiligo; LUSC trans rs9354352 0.935 rs9354354 chr6:66699333 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.63 -9.13 -0.45 6.91e-18 Initial pursuit acceleration in psychotic disorders; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04571327 chr6:97345972 NDUFAF4 0.41 6.25 0.32 1.26e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9612 1.000 rs61002661 chr19:44269032 T/A cg08581076 chr19:44259116 C19orf61 0.48 5.9 0.31 9.06e-9 Exhaled nitric oxide output; LUSC cis rs8099014 0.906 rs4940696 chr18:56106596 C/T cg12907477 chr18:56117327 MIR122 -0.42 -6.45 -0.33 3.86e-10 Platelet count; LUSC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg22834771 chr12:69754056 YEATS4 -0.54 -8.08 -0.4 1.23e-14 Cerebrospinal fluid biomarker levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25022925 chr5:126112600 LMNB1 0.41 6.04 0.31 4.09e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg06112835 chr11:68658793 MRPL21 0.52 8.1 0.41 1.06e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9625935 0.957 rs36607 chr22:30341260 G/T cg11564601 chr22:30592435 NA 0.38 5.68 0.3 2.96e-8 Tonsillectomy; LUSC cis rs8072100 0.967 rs4239163 chr17:45755954 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.35 -5.83 -0.3 1.29e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg21433313 chr16:3507492 NAT15 0.67 11.18 0.52 7.24e-25 Tuberculosis; LUSC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg09034736 chr1:150693464 HORMAD1 0.42 5.91 0.31 8.51e-9 Melanoma; LUSC cis rs4601821 0.635 rs11214579 chr11:113208186 A/C cg14159747 chr11:113255604 NA -0.24 -5.78 -0.3 1.69e-8 Alcoholic chronic pancreatitis; LUSC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg14416269 chr4:6271139 WFS1 0.47 10.14 0.49 2.94e-21 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6570726 0.905 rs375692 chr6:145840368 A/G cg05347473 chr6:146136440 FBXO30 0.4 6.78 0.35 5.5e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs734999 0.505 rs10797439 chr1:2540364 G/A cg18854424 chr1:2615690 NA 0.52 10.79 0.51 1.71e-23 Ulcerative colitis; LUSC trans rs1325195 0.920 rs2130576 chr1:179181102 T/C cg11624085 chr17:8464688 MYH10 0.41 6.58 0.34 1.87e-10 IgE grass sensitization; LUSC trans rs78547376 0.516 rs10445896 chr2:58390547 C/T cg10600964 chr10:114492301 VTI1A 0.56 6.11 0.32 2.83e-9 Neuroticism; LUSC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg18681998 chr4:17616180 MED28 0.85 15.42 0.64 7.01e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21440829 chr7:100808893 VGF 0.49 6.83 0.35 3.92e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4714291 0.832 rs3008839 chr6:40052660 G/A cg02267698 chr19:7991119 CTXN1 -0.53 -7.84 -0.39 6.31e-14 Strep throat; LUSC cis rs27434 0.583 rs149431 chr5:96157541 T/C cg16492584 chr5:96139282 ERAP1 -0.56 -7.53 -0.38 4.91e-13 Ankylosing spondylitis; LUSC cis rs477692 1.000 rs531572 chr10:131427569 A/G cg05714579 chr10:131428358 MGMT -0.51 -7.73 -0.39 1.32e-13 Response to temozolomide; LUSC cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg11584989 chr19:19387371 SF4 0.57 6.97 0.36 1.66e-11 Bipolar disorder; LUSC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg22823121 chr1:150693482 HORMAD1 0.49 7.03 0.36 1.18e-11 Melanoma; LUSC cis rs9300255 0.537 rs2682429 chr12:123642955 C/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.12 -0.32 2.63e-9 Neutrophil percentage of white cells; LUSC cis rs1577917 0.958 rs12197463 chr6:86445242 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.84 -0.44 5.48e-17 Response to antipsychotic treatment; LUSC cis rs4595586 0.545 rs12809206 chr12:39388748 A/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg08754478 chr10:133766260 PPP2R2D -0.63 -8.11 -0.41 9.61e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs12410462 0.581 rs112572966 chr1:227553905 C/T cg04117972 chr1:227635322 NA 0.58 6.46 0.33 3.76e-10 Major depressive disorder; LUSC cis rs243505 0.762 rs3779036 chr7:148488507 C/T cg09806900 chr7:148480153 CUL1 0.58 8.51 0.42 5.84e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1044826 0.642 rs295479 chr3:139223865 C/T cg15131784 chr3:139108705 COPB2 0.39 6.34 0.33 7.33e-10 Obesity-related traits; LUSC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg03709012 chr19:19516395 GATAD2A 0.84 13.9 0.61 5.86e-35 Tonsillectomy; LUSC cis rs62400317 0.859 rs10948221 chr6:45236707 T/G cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg16545954 chr1:2118288 C1orf86 -0.35 -6.76 -0.35 6.22e-11 Height; LUSC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg05110241 chr16:68378359 PRMT7 -0.55 -6.52 -0.34 2.6e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 4.99e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12464559 0.649 rs11896217 chr2:152591189 G/A cg01189475 chr2:152685088 ARL5A 0.62 5.67 0.3 3.06e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs77686669 1 rs77686669 chr7:99744572 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.43 -5.72 -0.3 2.42e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg16989719 chr2:238392110 NA 0.4 6.78 0.35 5.59e-11 Prostate cancer; LUSC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2742234 0.590 rs2435377 chr10:43683600 A/G cg15436174 chr10:43711423 RASGEF1A 0.43 7.16 0.36 5.27e-12 Hirschsprung disease; LUSC cis rs73198271 1.000 rs11775476 chr8:8607869 T/C cg01851573 chr8:8652454 MFHAS1 0.59 8.13 0.41 8.61e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg05347473 chr6:146136440 FBXO30 -0.61 -10.81 -0.51 1.45e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7824557 0.628 rs6988922 chr8:11194911 A/G cg21293242 chr8:11204541 TDH 0.32 5.98 0.31 5.69e-9 Retinal vascular caliber; LUSC cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.75 -0.51 2.45e-23 Chronic sinus infection; LUSC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs17095355 1.000 rs17126883 chr10:111694696 A/G cg00817464 chr10:111662876 XPNPEP1 -0.63 -7.39 -0.37 1.2e-12 Biliary atresia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08047886 chr11:57425128 CLP1 -0.41 -7.09 -0.36 8.28e-12 Electrocardiographic conduction measures; LUSC cis rs8044995 0.563 rs8059585 chr16:68376811 G/A cg05110241 chr16:68378359 PRMT7 -0.76 -8.7 -0.43 1.59e-16 Schizophrenia; LUSC cis rs977987 0.806 rs4888404 chr16:75428097 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.41e-11 Dupuytren's disease; LUSC cis rs354225 0.615 rs12713274 chr2:54848728 C/T cg26097391 chr2:54893211 SPTBN1 -0.43 -6.8 -0.35 4.82e-11 Schizophrenia; LUSC cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg14844989 chr11:31128820 NA -0.39 -6.02 -0.31 4.6e-9 Red blood cell count; LUSC trans rs8072100 0.790 rs7222225 chr17:45693497 A/G cg03886242 chr7:26192032 NFE2L3 0.41 6.5 0.34 2.94e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg11764359 chr7:65958608 NA 0.52 6.58 0.34 1.84e-10 Aortic root size; LUSC trans rs561341 0.883 rs7406056 chr17:30220224 C/T cg20587970 chr11:113659929 NA -1.06 -13.08 -0.58 7.3e-32 Hip circumference adjusted for BMI; LUSC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 8.12e-16 Aortic root size; LUSC cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg06191203 chr2:152266755 RIF1 -0.61 -8.29 -0.41 2.89e-15 Lung cancer; LUSC cis rs4343996 0.521 rs10499327 chr7:3407856 A/T cg21248987 chr7:3385318 SDK1 0.37 6.33 0.33 7.85e-10 Motion sickness; LUSC cis rs4319547 0.506 rs2062488 chr12:122804256 C/T cg05707623 chr12:122985044 ZCCHC8 0.5 6.3 0.33 9.47e-10 Body mass index; LUSC cis rs7296418 0.961 rs10848428 chr12:123572495 C/T cg05973401 chr12:123451056 ABCB9 0.63 9.19 0.45 4.35e-18 Platelet count; LUSC cis rs6429082 0.683 rs868815 chr1:235584543 C/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -7.57 -0.38 3.76e-13 Adiposity; LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs1670533 1.000 rs1010342 chr4:1068819 C/T cg02018176 chr4:1364513 KIAA1530 0.44 6.25 0.32 1.27e-9 Recombination rate (females); LUSC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg23711669 chr6:146136114 FBXO30 -0.85 -15.75 -0.65 3.47e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg09021430 chr5:549028 NA -0.54 -7.06 -0.36 9.57e-12 Lung disease severity in cystic fibrosis; LUSC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 16.98 0.68 4.78e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1034435 0.755 rs6007871 chr22:48894392 C/G cg05992904 chr22:48892994 FAM19A5 -0.39 -7.85 -0.39 5.79e-14 Late-onset Alzheimer's disease; LUSC cis rs10789491 1.000 rs2083485 chr1:47170091 G/C cg15501359 chr1:47185051 KIAA0494 0.82 11.6 0.54 2.34e-26 Response to hepatitis C treatment; LUSC trans rs12495832 0.778 rs1456669 chr3:147935635 A/C cg05062820 chr16:1098546 NA -0.41 -6.01 -0.31 4.91e-9 Chin dimples; LUSC cis rs12681287 0.640 rs10095498 chr8:87425651 C/T cg27223183 chr8:87520930 FAM82B 0.55 7.5 0.38 5.74e-13 Caudate activity during reward; LUSC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg23719950 chr11:63933701 MACROD1 -0.62 -8.12 -0.41 9.04e-15 Mean platelet volume; LUSC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg21918786 chr6:109611834 NA -0.41 -7.2 -0.37 3.92e-12 Reticulocyte fraction of red cells; LUSC cis rs7789940 0.904 rs6948661 chr7:75961647 T/C cg15798862 chr7:76129360 DTX2 -0.51 -8.54 -0.42 4.77e-16 Multiple sclerosis; LUSC cis rs6700896 0.931 rs4420065 chr1:66161461 T/C cg04111102 chr1:66153794 NA -0.34 -7.39 -0.37 1.19e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6690583 0.623 rs74761855 chr1:85432947 A/C cg22153463 chr1:85462885 MCOLN2 0.64 6.17 0.32 2.01e-9 Serum sulfate level; LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg15448220 chr1:150897856 SETDB1 0.42 6.16 0.32 2.12e-9 Melanoma; LUSC cis rs8017423 0.904 rs11622257 chr14:90715014 C/T cg14092571 chr14:90743983 NA 0.37 5.95 0.31 6.92e-9 Mortality in heart failure; LUSC cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg09165964 chr15:75287851 SCAMP5 -1.15 -19.33 -0.73 2.1e-56 Blood trace element (Zn levels); LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg05717871 chr11:638507 DRD4 -0.33 -5.84 -0.3 1.26e-8 Systemic lupus erythematosus; LUSC trans rs11992162 0.507 rs60902764 chr8:11784991 A/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.14 -0.32 2.31e-9 Monocyte count; LUSC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs6681460 0.649 rs967325 chr1:67003722 C/T cg02459107 chr1:67143332 SGIP1 0.37 6.04 0.31 4.22e-9 Presence of antiphospholipid antibodies; LUSC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg22782873 chr19:19639568 YJEFN3 -0.52 -6.06 -0.31 3.71e-9 Bipolar disorder; LUSC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg06494592 chr3:125709126 NA -0.52 -5.95 -0.31 6.8e-9 Blood pressure (smoking interaction); LUSC cis rs4654899 0.802 rs3767247 chr1:21227338 T/C cg01072550 chr1:21505969 NA -0.51 -7.55 -0.38 4.17e-13 Superior frontal gyrus grey matter volume; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg01238044 chr22:24384105 GSTT1 -0.52 -7.58 -0.38 3.51e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg11764359 chr7:65958608 NA -0.69 -10.61 -0.5 7.19e-23 Aortic root size; LUSC cis rs10791097 0.668 rs10791102 chr11:130744977 G/A cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9467773 1.000 rs2255070 chr6:26501777 C/G cg05738196 chr6:26577821 NA 0.8 15.1 0.64 1.22e-39 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.633 rs7770835 chr6:86608907 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.14 -0.32 2.32e-9 Response to antipsychotic treatment; LUSC trans rs9650657 0.537 rs4841457 chr8:10773511 T/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.52 -0.38 5.17e-13 Neuroticism; LUSC cis rs1371867 0.875 rs28595052 chr8:101327553 G/A cg06636551 chr8:101224915 SPAG1 -0.45 -8.12 -0.41 9.03e-15 Atrioventricular conduction; LUSC cis rs67460515 0.926 rs11715591 chr3:161043137 C/T cg03342759 chr3:160939853 NMD3 -0.51 -7.26 -0.37 2.74e-12 Parkinson's disease; LUSC cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg13736514 chr6:26305472 NA -0.45 -8.94 -0.44 2.72e-17 Educational attainment; LUSC cis rs208520 0.690 rs1233103 chr6:66855943 T/G cg07460842 chr6:66804631 NA -1.13 -17.75 -0.7 4.18e-50 Exhaled nitric oxide output; LUSC cis rs6681460 0.966 rs10749763 chr1:67062126 G/A cg02459107 chr1:67143332 SGIP1 0.46 8.64 0.43 2.4e-16 Presence of antiphospholipid antibodies; LUSC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.22e-8 Total body bone mineral density; LUSC cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -9.85 -0.47 2.9e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7927592 0.546 rs497261 chr11:68192244 T/C cg20283391 chr11:68216788 NA -0.53 -7.27 -0.37 2.53e-12 Total body bone mineral density; LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.75 0.35 6.62e-11 Platelet count; LUSC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg21963583 chr11:68658836 MRPL21 0.56 8.28 0.41 3.09e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9287719 0.967 rs12622765 chr2:10728331 T/C cg00105475 chr2:10696890 NA 0.37 6.09 0.32 3.03e-9 Prostate cancer; LUSC cis rs5009270 0.512 rs1024412 chr7:112247758 A/G cg27282281 chr7:112262583 NA 0.45 6.03 0.31 4.32e-9 Osteoarthritis (hip); LUSC trans rs2797160 1.000 rs6569435 chr6:125998186 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.11e-10 Endometrial cancer; LUSC cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg16482183 chr6:26056742 HIST1H1C -0.52 -7.27 -0.37 2.57e-12 Iron status biomarkers; LUSC cis rs17401966 0.558 rs12128374 chr1:10426417 G/A cg17425144 chr1:10567563 PEX14 -0.34 -6.08 -0.32 3.32e-9 Hepatocellular carcinoma; LUSC cis rs9325144 0.600 rs1817648 chr12:38733424 C/T cg26384229 chr12:38710491 ALG10B -0.6 -9.34 -0.46 1.42e-18 Morning vs. evening chronotype; LUSC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg08270630 chr22:50330655 NA -0.43 -6.43 -0.33 4.39e-10 Schizophrenia; LUSC cis rs11190604 1.000 rs7100386 chr10:102301417 C/T cg07080220 chr10:102295463 HIF1AN 0.69 9.22 0.45 3.53e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg00166722 chr3:10149974 C3orf24 0.39 5.81 0.3 1.43e-8 Alzheimer's disease; LUSC trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg15704280 chr7:45808275 SEPT13 -0.88 -12.2 -0.56 1.52e-28 Coronary artery disease; LUSC cis rs3125734 0.633 rs7088891 chr10:64034019 G/T cg19640130 chr10:64028056 RTKN2 -0.41 -7.06 -0.36 9.51e-12 Rheumatoid arthritis; LUSC trans rs488628 1.000 rs513011 chr3:118130697 C/G cg06621744 chr14:37052470 NKX2-8 -0.29 -6.47 -0.33 3.56e-10 White matter integrity (bipolar disorder risk interaction); LUSC cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg09626299 chr10:82213104 TSPAN14 -0.21 -5.97 -0.31 6.12e-9 Post bronchodilator FEV1; LUSC cis rs6087990 0.806 rs1474738 chr20:31380309 G/A cg13636640 chr20:31349939 DNMT3B 0.9 18.13 0.7 1.27e-51 Ulcerative colitis; LUSC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg13114125 chr14:105738426 BRF1 -0.95 -15.95 -0.66 5.69e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg01579765 chr21:45077557 HSF2BP 0.55 11.55 0.53 3.57e-26 Mean corpuscular volume; LUSC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg15744005 chr10:104629667 AS3MT -0.28 -5.89 -0.31 9.58e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1413885 0.549 rs4593866 chr1:65850968 G/C cg14976592 chr1:65886160 LEPROT;LEPR 0.49 7.21 0.37 3.66e-12 Anticoagulant levels; LUSC cis rs2273669 0.667 rs2003315 chr6:109367169 C/T cg05315195 chr6:109294784 ARMC2 -0.53 -5.79 -0.3 1.6e-8 Prostate cancer; LUSC cis rs10072221 0.836 rs11738470 chr5:75693904 A/G cg03132911 chr5:75698732 IQGAP2 -0.37 -6.33 -0.33 7.82e-10 Mean platelet volume; LUSC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg03806693 chr22:41940476 POLR3H 1.03 14.29 0.62 1.71e-36 Vitiligo; LUSC cis rs7582180 0.614 rs1530030 chr2:101009600 G/A cg12002119 chr2:101014098 CHST10 0.36 5.92 0.31 8.07e-9 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.869 rs2777473 chr6:146301494 G/A cg23711669 chr6:146136114 FBXO30 0.77 13.37 0.59 5.92e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs2425143 1.000 rs78421482 chr20:34376486 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -5.7 -0.3 2.64e-8 Blood protein levels; LUSC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.94 -0.4 3.13e-14 Mean platelet volume; LUSC cis rs66887589 0.616 rs13113885 chr4:120221176 G/C cg09307838 chr4:120376055 NA 0.53 7.85 0.39 5.52e-14 Diastolic blood pressure; LUSC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.3 0.41 2.56e-15 Axial length; LUSC cis rs500891 0.645 rs1180192 chr6:83964709 C/T cg08257003 chr6:84140564 ME1 0.29 6.53 0.34 2.38e-10 Platelet-derived growth factor BB levels; LUSC trans rs6461503 0.644 rs916789 chr7:20572530 A/C cg06798092 chr14:50328478 NA 0.38 5.97 0.31 6.14e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs72781680 0.898 rs12623333 chr2:24111823 T/G cg08917208 chr2:24149416 ATAD2B 0.87 9.73 0.47 7.07e-20 Lymphocyte counts; LUSC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.5 -0.33 2.99e-10 Lung cancer; LUSC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg17971929 chr21:40555470 PSMG1 -0.7 -11.58 -0.54 2.74e-26 Cognitive function; LUSC cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg02527881 chr3:46936655 PTH1R -0.66 -12.16 -0.55 2.02e-28 Birth weight; LUSC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg19622623 chr12:86230825 RASSF9 0.39 5.72 0.3 2.4e-8 Major depressive disorder; LUSC cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg03709012 chr19:19516395 GATAD2A -0.82 -12.97 -0.58 1.9e-31 Tonsillectomy; LUSC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg10523679 chr1:76189770 ACADM 0.89 15.49 0.65 3.73e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11645898 0.872 rs4788459 chr16:72153125 C/G cg14768367 chr16:72042858 DHODH -0.63 -7.24 -0.37 3.03e-12 Blood protein levels; LUSC cis rs7582180 0.676 rs4264577 chr2:100930662 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.36 -0.42 1.72e-15 Intelligence (multi-trait analysis); LUSC cis rs4919087 0.926 rs953097 chr10:98981914 T/C cg25902810 chr10:99078978 FRAT1 0.5 7.1 0.36 7.66e-12 Monocyte count; LUSC cis rs1506636 0.962 rs1019220 chr7:123365122 G/A cg03229431 chr7:123269106 ASB15 -0.65 -10.57 -0.5 9.99e-23 Plateletcrit;Platelet count; LUSC cis rs1451375 0.698 rs68143668 chr7:50638110 C/T cg18232548 chr7:50535776 DDC 0.51 7.59 0.38 3.31e-13 Malaria; LUSC trans rs7786808 0.525 rs10253961 chr7:158194858 G/A cg02030672 chr11:45687055 CHST1 -0.43 -6.72 -0.35 7.63e-11 Obesity-related traits; LUSC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg14391382 chr7:866102 UNC84A 0.42 6.35 0.33 6.88e-10 Subjective well-being; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.95 -0.36 1.88e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3772130 0.775 rs6769102 chr3:121560722 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.68 9.91 0.48 1.88e-20 Cognitive performance; LUSC trans rs35110281 0.659 rs11909064 chr21:45092095 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.62 10.45 0.5 2.57e-22 Mean corpuscular volume; LUSC cis rs478304 0.654 rs11227260 chr11:65461158 G/T cg27068330 chr11:65405492 SIPA1 -0.77 -10.79 -0.51 1.67e-23 Acne (severe); LUSC trans rs7937682 0.924 rs875257 chr11:111530453 A/G cg18187862 chr3:45730750 SACM1L 0.55 7.09 0.36 8.01e-12 Primary sclerosing cholangitis; LUSC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg08132940 chr7:1081526 C7orf50 -0.48 -6.21 -0.32 1.59e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg18758796 chr5:131593413 PDLIM4 -0.39 -6.18 -0.32 1.89e-9 Breast cancer; LUSC trans rs4332037 0.901 rs7791899 chr7:1935988 T/C cg11693508 chr17:37793320 STARD3 0.65 7.91 0.4 3.9e-14 Bipolar disorder; LUSC cis rs9486715 0.867 rs9373829 chr6:96897201 A/C cg06623918 chr6:96969491 KIAA0776 -0.94 -17.56 -0.69 2.39e-49 Headache; LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg11645453 chr3:52864694 ITIH4 0.36 8.63 0.43 2.5e-16 Bipolar disorder; LUSC cis rs4319547 0.774 rs10773394 chr12:123124778 C/A cg05707623 chr12:122985044 ZCCHC8 -0.52 -7.35 -0.37 1.53e-12 Body mass index; LUSC cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 3.09e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg15704280 chr7:45808275 SEPT13 0.93 13.53 0.6 1.44e-33 Height; LUSC cis rs6500395 0.963 rs2041921 chr16:48714002 T/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.73 -0.35 7.3e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4363385 0.510 rs11576797 chr1:153049417 T/C cg00922841 chr1:152955080 SPRR1A -0.38 -6.31 -0.33 8.73e-10 Inflammatory skin disease; LUSC cis rs12579753 0.956 rs7309624 chr12:82204266 C/A cg21231944 chr12:82153410 PPFIA2 -0.38 -5.85 -0.3 1.15e-8 Resting heart rate; LUSC cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs611744 0.647 rs2594357 chr8:109255989 A/G cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 8.12e-10 Dupuytren's disease; LUSC cis rs1801251 1.000 rs11679079 chr2:233612656 C/T cg08000102 chr2:233561755 GIGYF2 0.68 11.26 0.52 3.82e-25 Coronary artery disease; LUSC cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg24642439 chr20:33292090 TP53INP2 0.53 8.16 0.41 6.81e-15 Glomerular filtration rate (creatinine); LUSC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg21433313 chr16:3507492 NAT15 -0.81 -8.94 -0.44 2.63e-17 Tuberculosis; LUSC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11890956 chr21:40555474 PSMG1 1.02 19.93 0.74 8.56e-59 Cognitive function; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg23974812 chr11:134123664 THYN1;ACAD8 -0.36 -6.13 -0.32 2.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.52 -7.24 -0.37 3.18e-12 Renal function-related traits (BUN); LUSC cis rs7647973 0.961 rs6778080 chr3:49317338 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.41 -6.14 -0.32 2.4e-9 Menarche (age at onset); LUSC cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7959452 0.640 rs11177599 chr12:69721970 G/A cg20891283 chr12:69753455 YEATS4 0.66 10.49 0.5 1.89e-22 Blood protein levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11204671 chr14:24583351 DCAF11 -0.48 -6.39 -0.33 5.63e-10 Bipolar disorder and schizophrenia; LUSC trans rs61931739 0.963 rs1817759 chr12:34101521 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.79 -0.39 8.36e-14 Morning vs. evening chronotype; LUSC cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg13902645 chr11:5959945 NA -0.63 -9.03 -0.44 1.43e-17 DNA methylation (variation); LUSC cis rs10791323 0.602 rs7946895 chr11:133733893 T/C cg00579200 chr11:133705235 NA -0.41 -6.26 -0.32 1.16e-9 Childhood ear infection; LUSC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg13206674 chr6:150067644 NUP43 0.58 9.08 0.45 9.37e-18 Lung cancer; LUSC trans rs6089829 0.962 rs2277768 chr20:61666823 T/C cg15934090 chr1:100435551 SLC35A3 0.49 8.49 0.42 7.11e-16 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -10.61 -0.5 7.3e-23 Chronic sinus infection; LUSC cis rs4409675 0.576 rs2815707 chr1:28238880 T/C cg23691781 chr1:28212827 C1orf38 0.32 7.87 0.4 5.06e-14 Corneal astigmatism; LUSC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg18350739 chr11:68623251 NA -0.39 -7.2 -0.37 4.06e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs478304 0.593 rs9666878 chr11:65475816 A/C cg27068330 chr11:65405492 SIPA1 0.73 10.18 0.49 2.16e-21 Acne (severe); LUSC trans rs208520 0.909 rs9354410 chr6:67018584 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 8.52 0.42 5.37e-16 Exhaled nitric oxide output; LUSC cis rs7180079 0.544 rs674745 chr15:64847554 A/G cg08069370 chr15:64387884 SNX1 0.52 5.82 0.3 1.4e-8 Monocyte count; LUSC trans rs62458065 0.513 rs702831 chr7:32579715 C/T cg00845942 chr12:64062724 DPY19L2 -0.62 -7.92 -0.4 3.6e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg14893161 chr1:205819251 PM20D1 -0.43 -6.01 -0.31 4.93e-9 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs41271473 0.500 rs10916366 chr1:228894575 T/C cg00850481 chr1:228891306 NA -0.37 -5.79 -0.3 1.64e-8 Chronic lymphocytic leukemia; LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg23590916 chr17:43697445 MGC57346 0.5 6.81 0.35 4.51e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs12950390 0.853 rs17700008 chr17:45863591 A/C cg06532163 chr17:45867833 NA -0.33 -6.49 -0.33 3.19e-10 IgG glycosylation; LUSC cis rs72960926 0.744 rs1931273 chr6:74950660 A/T cg03266952 chr6:74778945 NA -0.81 -6.08 -0.32 3.25e-9 Metabolite levels (MHPG); LUSC cis rs2730245 0.527 rs2527202 chr7:158738849 T/C cg11984989 chr7:158649758 WDR60 -1.05 -11.65 -0.54 1.52e-26 Height; LUSC trans rs1729836 0.959 rs2698256 chr7:52763843 C/T cg11852671 chr15:96960214 NA -0.36 -5.96 -0.31 6.49e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs6066835 1.000 rs6066831 chr20:47354131 C/A cg18078177 chr20:47281410 PREX1 0.71 6.21 0.32 1.61e-9 Multiple myeloma; LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg16606324 chr3:10149918 C3orf24 0.59 8.6 0.43 3.15e-16 Alzheimer's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08830818 chr3:122514143 HSPBAP1;DIRC2 -0.4 -6.22 -0.32 1.49e-9 Bipolar disorder and schizophrenia; LUSC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg14541582 chr5:601475 NA -0.37 -5.71 -0.3 2.48e-8 Lung disease severity in cystic fibrosis; LUSC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg19920283 chr7:105172520 RINT1 0.59 6.07 0.32 3.45e-9 Bipolar disorder (body mass index interaction); LUSC cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg12386194 chr3:101231763 SENP7 -0.5 -7.1 -0.36 7.36e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6681460 0.966 rs10889643 chr1:67143368 G/C cg02459107 chr1:67143332 SGIP1 0.48 8.8 0.43 7.38e-17 Presence of antiphospholipid antibodies; LUSC cis rs243505 0.898 rs243535 chr7:148410123 A/C cg09806900 chr7:148480153 CUL1 -0.47 -6.66 -0.34 1.12e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8114671 0.562 rs6120746 chr20:33448496 A/G cg24642439 chr20:33292090 TP53INP2 0.43 6.12 0.32 2.59e-9 Height; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg06600287 chr1:53387719 ECHDC2 -0.28 -5.74 -0.3 2.11e-8 Monocyte count; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg06815965 chr1:205818668 PM20D1 0.39 5.9 0.31 8.76e-9 Menarche (age at onset); LUSC cis rs4629180 1.000 rs13031791 chr2:102108790 T/C cg01388757 chr2:102091195 RFX8 0.48 7.64 0.39 2.37e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs2273669 0.667 rs77002235 chr6:109321497 G/A cg05315195 chr6:109294784 ARMC2 -0.56 -6.21 -0.32 1.54e-9 Prostate cancer; LUSC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg26408565 chr15:76604113 ETFA -0.51 -8.15 -0.41 7.45e-15 Blood metabolite levels; LUSC cis rs7267979 0.932 rs6132848 chr20:25561645 C/T cg08601574 chr20:25228251 PYGB 0.39 5.96 0.31 6.48e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg05234568 chr11:5960015 NA -0.59 -8.46 -0.42 8.25e-16 DNA methylation (variation); LUSC cis rs7124681 0.584 rs10769285 chr11:47709212 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.87e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC trans rs7937682 0.575 rs34888817 chr11:111756455 C/T cg18187862 chr3:45730750 SACM1L -0.52 -6.3 -0.33 9.22e-10 Primary sclerosing cholangitis; LUSC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.85 0.35 3.67e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6502050 0.835 rs10163482 chr17:80110394 C/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.69e-10 Life satisfaction; LUSC cis rs7267979 1.000 rs2500436 chr20:25406366 G/C cg08601574 chr20:25228251 PYGB -0.45 -6.89 -0.35 2.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg16322792 chr1:120165303 ZNF697 0.74 15.5 0.65 3.38e-41 Systemic lupus erythematosus; LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg13047869 chr3:10149882 C3orf24 0.61 8.74 0.43 1.18e-16 Alzheimer's disease; LUSC cis rs8114671 0.967 rs2093058 chr20:33791281 C/T cg07148914 chr20:33460835 GGT7 -0.44 -6.54 -0.34 2.25e-10 Height; LUSC trans rs61931739 0.500 rs7488438 chr12:34531359 G/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs7582180 0.638 rs6734316 chr2:100976210 A/G cg12002119 chr2:101014098 CHST10 0.35 5.81 0.3 1.49e-8 Intelligence (multi-trait analysis); LUSC cis rs3772130 0.962 rs9839617 chr3:121516577 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.21 0.49 1.78e-21 Cognitive performance; LUSC cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg24558204 chr6:135376177 HBS1L -0.68 -11.06 -0.52 1.95e-24 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs11122272 0.766 rs2790871 chr1:231543555 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.69 -10.9 -0.51 6.89e-24 Hemoglobin concentration; LUSC cis rs62400317 0.793 rs6924185 chr6:45017228 C/A cg20913747 chr6:44695427 NA -0.46 -7.46 -0.38 7.68e-13 Total body bone mineral density; LUSC cis rs4478858 0.624 rs10914333 chr1:31701491 A/G cg00250761 chr1:31883323 NA -0.31 -7.74 -0.39 1.2e-13 Alcohol dependence; LUSC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg22823121 chr1:150693482 HORMAD1 0.47 6.65 0.34 1.17e-10 Melanoma; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg03934478 chr11:495069 RNH1 0.9 10.16 0.49 2.55e-21 Body mass index; LUSC cis rs934734 0.563 rs1858037 chr2:65598300 T/A cg08085232 chr2:65598271 SPRED2 -0.44 -6.9 -0.35 2.56e-11 Rheumatoid arthritis; LUSC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg08048268 chr3:133502702 NA 0.46 8.81 0.43 7.09e-17 Iron status biomarkers; LUSC cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg04545296 chr12:48745243 ZNF641 0.36 6.66 0.34 1.15e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs6484504 0.625 rs4922859 chr11:31382517 A/G cg06552810 chr11:31128660 NA 0.38 6.62 0.34 1.45e-10 Red blood cell count; LUSC cis rs1348850 0.632 rs1358328 chr2:178517532 G/A cg22681709 chr2:178499509 PDE11A -0.59 -11.79 -0.54 4.57e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs780094 0.500 rs4665987 chr2:27755825 G/A cg27432699 chr2:27873401 GPN1 0.4 5.67 0.3 3.16e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs6060717 0.536 rs11697851 chr20:34524494 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -5.8 -0.3 1.53e-8 Hip circumference adjusted for BMI; LUSC cis rs3768617 0.510 rs2093984 chr1:183094314 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.07 0.52 1.78e-24 Fuchs's corneal dystrophy; LUSC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg17971929 chr21:40555470 PSMG1 -0.48 -6.93 -0.35 2.18e-11 Menarche (age at onset); LUSC cis rs478304 0.934 rs506853 chr11:65521247 C/T cg08755490 chr11:65554678 OVOL1 0.41 5.87 0.31 1.05e-8 Acne (severe); LUSC cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs10498514 0.793 rs74673631 chr14:65047841 A/T cg25134081 chr14:64931936 AKAP5 0.97 6.73 0.35 7.22e-11 Cognitive performance; LUSC cis rs1801251 0.778 rs2250665 chr2:233752639 A/T cg08000102 chr2:233561755 GIGYF2 -0.5 -7.73 -0.39 1.3e-13 Coronary artery disease; LUSC cis rs814295 1.000 rs814295 chr2:27743215 A/G cg27432699 chr2:27873401 GPN1 0.49 5.89 0.31 9.46e-9 Triglyceride levels; LUSC cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg26384229 chr12:38710491 ALG10B -0.91 -17.16 -0.68 9.16e-48 Heart rate; LUSC cis rs523522 0.962 rs687873 chr12:121019634 G/A cg12219531 chr12:120966889 COQ5 0.66 9.11 0.45 7.8e-18 High light scatter reticulocyte count; LUSC cis rs11051970 0.636 rs2651368 chr12:32561506 T/C cg24626660 chr12:32551988 NA 0.31 5.66 0.3 3.25e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg26513180 chr16:89883248 FANCA 0.91 17.79 0.7 2.82e-50 Vitiligo; LUSC cis rs2236918 1.000 rs1776137 chr1:242027045 A/G cg17736920 chr1:242011382 EXO1 0.44 6.93 0.35 2.12e-11 Menopause (age at onset); LUSC cis rs2354432 0.556 rs12568866 chr1:146718430 A/C cg25205988 chr1:146714368 CHD1L -1.0 -9.49 -0.46 4.59e-19 Mitochondrial DNA levels; LUSC cis rs6840360 0.550 rs11723438 chr4:152531801 C/T cg22705602 chr4:152727874 NA 0.33 6.78 0.35 5.4e-11 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.52e-8 Extrinsic epigenetic age acceleration; LUSC trans rs57046232 0.552 rs6085506 chr20:6326507 T/C cg21095983 chr6:86352623 SYNCRIP 0.5 7.35 0.37 1.49e-12 Colorectal cancer; LUSC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg11663144 chr21:46675770 NA -0.41 -7.19 -0.37 4.15e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2486288 0.656 rs8039354 chr15:45551756 A/G cg26924012 chr15:45694286 SPATA5L1 0.73 11.14 0.52 1.01e-24 Glomerular filtration rate; LUSC cis rs10876993 0.928 rs10877008 chr12:58103592 A/G cg18357645 chr12:58087776 OS9 0.57 8.58 0.42 3.74e-16 Celiac disease or Rheumatoid arthritis; LUSC trans rs11039798 0.588 rs6485891 chr11:48612024 T/A cg15704280 chr7:45808275 SEPT13 0.66 7.2 0.37 4.14e-12 Axial length; LUSC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6840360 1.000 rs749982 chr4:152601353 A/G cg22705602 chr4:152727874 NA -0.27 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.624 rs9457260 chr6:167466665 C/T cg07741184 chr6:167504864 NA 0.49 8.61 0.43 3.03e-16 Crohn's disease; LUSC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 10.09 0.48 4.6e-21 Bipolar disorder; LUSC cis rs8078723 0.933 rs4794822 chr17:38156712 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.82 -0.35 4.38e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs7495211 0.529 rs12592382 chr15:98624268 A/C cg08901157 chr15:56033728 PRTG -0.34 -6.08 -0.32 3.23e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg08859206 chr1:53392774 SCP2 -0.58 -10.87 -0.51 9.47e-24 Monocyte count; LUSC cis rs4654899 0.865 rs9426730 chr1:21452255 A/T cg01072550 chr1:21505969 NA -0.53 -8.2 -0.41 5.28e-15 Superior frontal gyrus grey matter volume; LUSC cis rs1865760 0.533 rs1408270 chr6:25873184 A/G cg16482183 chr6:26056742 HIST1H1C 0.59 7.99 0.4 2.15e-14 Height; LUSC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg02187348 chr16:89574699 SPG7 0.58 9.31 0.45 1.79e-18 Multiple myeloma (IgH translocation); LUSC cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg17420585 chr12:42539391 GXYLT1 -0.56 -12.58 -0.57 5.7e-30 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2652834 1.000 rs2652816 chr15:63403368 C/T cg05507819 chr15:63340323 TPM1 0.66 8.03 0.4 1.73e-14 HDL cholesterol; LUSC cis rs6847149 0.929 rs11736783 chr4:110808321 A/G cg07850274 chr4:110748770 RRH -0.49 -7.07 -0.36 8.84e-12 Exercise treadmill test traits; LUSC cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg05347473 chr6:146136440 FBXO30 0.51 8.55 0.42 4.64e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs8017423 0.967 rs8022531 chr14:90729931 T/C cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs67366981 0.720 rs4396457 chr14:77685379 G/A cg22824376 chr14:77648248 TMEM63C 0.88 8.51 0.42 5.88e-16 Obsessive-compulsive symptoms; LUSC cis rs9611565 0.607 rs132792 chr22:42062822 C/T cg17376030 chr22:41985996 PMM1 -0.42 -5.66 -0.3 3.25e-8 Vitiligo; LUSC cis rs2692947 0.696 rs2576437 chr2:96800417 T/C cg23100626 chr2:96804247 ASTL 0.26 6.44 0.33 4.09e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7568458 0.777 rs12473819 chr2:85773061 A/G cg02493740 chr2:85810744 VAMP5 -0.38 -6.73 -0.35 7.18e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg23649088 chr2:200775458 C2orf69 0.54 7.35 0.37 1.58e-12 Schizophrenia; LUSC cis rs9831754 0.906 rs7621811 chr3:78388816 G/A cg06138941 chr3:78371609 NA -0.66 -8.99 -0.44 1.89e-17 Calcium levels; LUSC cis rs7804356 0.906 rs12540388 chr7:26905731 A/T cg03456212 chr7:26904342 SKAP2 -0.58 -6.65 -0.34 1.22e-10 Type 1 diabetes; LUSC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg04414720 chr1:150670196 GOLPH3L 0.56 8.59 0.43 3.49e-16 Urate levels; LUSC cis rs4144743 1.000 rs10438781 chr17:45323819 A/G cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs7760535 0.763 rs10457241 chr6:111849034 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.38 -7.18 -0.37 4.41e-12 Metabolic traits; LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs9487051 0.768 rs463916 chr6:109520538 A/G cg00509249 chr6:109615579 CCDC162 -0.34 -5.87 -0.31 1.06e-8 Reticulocyte fraction of red cells; LUSC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.29 0.33 9.74e-10 Mean platelet volume; LUSC cis rs7727544 0.625 rs3091338 chr5:131402738 C/T cg14196790 chr5:131705035 SLC22A5 0.44 6.57 0.34 1.96e-10 Blood metabolite levels; LUSC cis rs877282 0.733 rs11253342 chr10:765072 A/G cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC cis rs9467773 1.000 rs6932156 chr6:26571506 T/G cg11502198 chr6:26597334 ABT1 0.64 10.06 0.48 5.52e-21 Intelligence (multi-trait analysis); LUSC cis rs6732160 0.691 rs10197935 chr2:73412362 A/T cg24220031 chr2:73402428 NA -0.23 -5.71 -0.3 2.45e-8 Intelligence (multi-trait analysis); LUSC cis rs12950390 0.853 rs55745341 chr17:45855778 G/C cg06532163 chr17:45867833 NA 0.34 6.3 0.33 9.46e-10 IgG glycosylation; LUSC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC cis rs13253111 0.687 rs7840565 chr8:28060783 C/T cg26534493 chr8:28060551 NA 0.36 6.57 0.34 1.89e-10 Childhood body mass index; LUSC cis rs865483 0.895 rs2522972 chr17:35839021 C/T cg06716730 chr17:35851459 DUSP14 0.26 5.83 0.3 1.3e-8 Monocyte count; LUSC cis rs3020736 0.500 rs5996110 chr22:42493767 A/G cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg14416269 chr4:6271139 WFS1 0.5 10.1 0.48 4.12e-21 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg01028140 chr2:1542097 TPO -0.6 -7.98 -0.4 2.45e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.12 0.66 1.24e-43 Platelet count; LUSC cis rs983392 0.679 rs654415 chr11:60013674 G/A cg02771260 chr11:59836817 MS4A3 0.37 6.15 0.32 2.16e-9 Alzheimer's disease (late onset); LUSC cis rs3770081 1.000 rs76081054 chr2:86285037 T/G cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.99 -0.36 1.51e-11 Facial emotion recognition (sad faces); LUSC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg15445000 chr17:37608096 MED1 0.4 6.81 0.35 4.65e-11 Glomerular filtration rate (creatinine); LUSC cis rs7681440 0.904 rs7671549 chr4:90771147 T/A cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.3 1.17e-8 Dementia with Lewy bodies; LUSC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg08132940 chr7:1081526 C7orf50 -0.48 -6.2 -0.32 1.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg11062466 chr8:58055876 NA 0.55 7.36 0.37 1.41e-12 Developmental language disorder (linguistic errors); LUSC cis rs11166629 0.502 rs2439813 chr8:135669158 C/T cg27224718 chr8:135614730 ZFAT 0.49 7.55 0.38 4.13e-13 Smoking quantity; LUSC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg06609049 chr19:2785107 THOP1 1.12 22.16 0.77 1.43e-67 Total cholesterol levels; LUSC cis rs9388451 0.903 rs9388446 chr6:126064920 T/A cg10911889 chr6:126070802 HEY2 0.4 6.19 0.32 1.72e-9 Brugada syndrome; LUSC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.16 -0.36 5.18e-12 Bipolar disorder; LUSC cis rs2404602 0.655 rs4886507 chr15:77209694 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.5 -0.38 5.78e-13 Blood metabolite levels; LUSC cis rs1371867 0.875 rs1788174 chr8:101330957 C/G cg00191853 chr8:101177733 SPAG1 0.36 5.77 0.3 1.84e-8 Atrioventricular conduction; LUSC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg00310523 chr12:86230176 RASSF9 0.5 9.52 0.46 3.51e-19 Major depressive disorder; LUSC cis rs11098499 0.909 rs1546504 chr4:120241179 C/T cg09307838 chr4:120376055 NA 0.81 11.76 0.54 5.77e-27 Corneal astigmatism; LUSC cis rs453301 0.653 rs1562211 chr8:8902424 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.58 -0.46 2.28e-19 Joint mobility (Beighton score); LUSC cis rs9652601 0.959 rs7200940 chr16:11164567 G/C cg04616529 chr16:11181986 CLEC16A -0.34 -5.92 -0.31 8.13e-9 Systemic lupus erythematosus; LUSC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06544989 chr22:39130855 UNC84B -0.34 -5.99 -0.31 5.54e-9 Menopause (age at onset); LUSC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.53e-8 Menopause (age at onset); LUSC trans rs62238980 0.614 rs117256264 chr22:32381750 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs367615 0.704 rs6889301 chr5:108835181 C/T cg17395555 chr5:108820864 NA 0.63 11.42 0.53 9.71e-26 Colorectal cancer (SNP x SNP interaction); LUSC cis rs7605827 0.930 rs13035937 chr2:15698050 C/T cg19274914 chr2:15703543 NA -0.47 -9.02 -0.44 1.46e-17 Educational attainment (years of education); LUSC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.68 0.3 2.87e-8 Self-reported allergy; LUSC cis rs11997175 0.603 rs4291230 chr8:33674570 A/C ch.8.33884649F chr8:33765107 NA -0.45 -6.58 -0.34 1.87e-10 Body mass index; LUSC cis rs11122272 0.735 rs910822 chr1:231498721 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.01 -0.48 8.34e-21 Hemoglobin concentration; LUSC trans rs17685 0.767 rs10954732 chr7:75611149 G/A cg19862616 chr7:65841803 NCRNA00174 -0.95 -15.4 -0.64 8.61e-41 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs600231 0.508 rs11227201 chr11:65242548 G/A cg17120908 chr11:65337727 SSSCA1 -0.61 -8.8 -0.43 7.42e-17 Bone mineral density; LUSC cis rs4954585 0.659 rs13018756 chr2:137008235 C/T cg05194412 chr2:137003533 NA 0.41 7.51 0.38 5.32e-13 Colorectal cancer; LUSC cis rs6469656 1.000 rs4601347 chr8:117687218 C/A cg24004040 chr8:117650383 NA -0.43 -6.23 -0.32 1.41e-9 Colorectal cancer; LUSC trans rs9329221 0.736 rs34381075 chr8:10243785 C/G cg08975724 chr8:8085496 FLJ10661 0.45 6.09 0.32 3.06e-9 Neuroticism; LUSC cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14442939 chr10:27389572 ANKRD26 -0.88 -9.91 -0.48 1.79e-20 Breast cancer; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -8.61 -0.43 2.94e-16 Developmental language disorder (linguistic errors); LUSC trans rs8060686 0.516 rs7193701 chr16:68185160 A/G cg13503067 chr12:58176460 TSFM 0.42 6.05 0.31 3.83e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1018836 0.786 rs4734237 chr8:91533361 A/C cg16814680 chr8:91681699 NA 0.6 9.21 0.45 3.64e-18 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg07606381 chr6:8435919 SLC35B3 0.73 12.5 0.56 1.14e-29 Motion sickness; LUSC cis rs4980532 1 rs4980532 chr11:63680719 C/T cg04850017 chr11:63683019 RCOR2 0.49 10.83 0.51 1.22e-23 Pulse pressure; LUSC cis rs10197940 0.624 rs3771901 chr2:152432481 G/A cg06191203 chr2:152266755 RIF1 -0.54 -7.28 -0.37 2.37e-12 Lung cancer; LUSC cis rs2667011 0.512 rs62176719 chr2:160817963 C/T cg06573604 chr2:160760825 LY75 0.46 6.34 0.33 7.48e-10 Bilirubin levels; LUSC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg22166914 chr1:53195759 ZYG11B -0.56 -8.76 -0.43 9.77e-17 Monocyte count; LUSC cis rs4363385 0.934 rs4240865 chr1:152954839 G/T cg07796016 chr1:152779584 LCE1C 0.41 5.8 0.3 1.58e-8 Inflammatory skin disease; LUSC cis rs9814567 1.000 rs9828815 chr3:134265749 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7647973 0.566 rs57630346 chr3:49086215 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.66 9.51 0.46 3.77e-19 Menarche (age at onset); LUSC cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg02175503 chr12:58329896 NA 0.49 7.11 0.36 7.27e-12 Intelligence (multi-trait analysis); LUSC cis rs12541635 0.934 rs2029882 chr8:107022894 G/A cg10147462 chr8:107024639 NA 0.55 9.87 0.48 2.51e-20 Age of smoking initiation; LUSC cis rs4356932 0.691 rs2242471 chr4:76878716 G/C cg00809888 chr4:76862425 NAAA -0.36 -5.72 -0.3 2.31e-8 Blood protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23657003 chr1:1014978 NA 0.42 6.28 0.32 1.05e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs7000551 0.556 rs6998780 chr8:22254639 C/T cg12081754 chr8:22256438 SLC39A14 0.98 15.51 0.65 3e-41 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9486719 1.000 rs9373978 chr6:97056255 T/C cg06623918 chr6:96969491 KIAA0776 -0.83 -10.11 -0.48 3.96e-21 Migraine;Coronary artery disease; LUSC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg10560079 chr2:191398806 TMEM194B -0.45 -7.41 -0.38 1.04e-12 Pulse pressure; LUSC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg04455712 chr21:45112962 RRP1B -0.47 -8.94 -0.44 2.7e-17 Mean corpuscular volume; LUSC cis rs9372253 0.843 rs9386895 chr6:110719632 T/A cg01119278 chr6:110721349 DDO -0.49 -8.85 -0.44 5.04e-17 Platelet distribution width; LUSC cis rs10911363 0.592 rs2702180 chr1:183517971 T/C cg09173681 chr1:183549694 NCF2 0.66 12.0 0.55 7.9e-28 Systemic lupus erythematosus; LUSC trans rs62458065 0.713 rs62463967 chr7:32498329 G/A cg00845942 chr12:64062724 DPY19L2 -0.55 -6.58 -0.34 1.8e-10 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg24812749 chr6:127587940 RNF146 0.7 9.89 0.48 2.07e-20 Breast cancer; LUSC trans rs7613875 0.620 rs11721204 chr3:49982765 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.53 8.27 0.41 3.11e-15 Body mass index; LUSC cis rs1878931 0.559 rs1968055 chr16:3392053 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.62 9.97 0.48 1.15e-20 Body mass index (adult); LUSC trans rs1949829 0.826 rs4947596 chr7:51537143 T/C cg20941110 chr15:83953819 BNC1 0.55 6.01 0.31 4.98e-9 Wegener's granulomatosis; LUSC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg00579200 chr11:133705235 NA -0.39 -5.66 -0.3 3.22e-8 Childhood ear infection; LUSC cis rs6494488 0.500 rs72742923 chr15:64855696 C/T cg08069370 chr15:64387884 SNX1 -0.64 -5.73 -0.3 2.24e-8 Coronary artery disease; LUSC cis rs2404602 0.735 rs2454450 chr15:76831236 G/A cg23625390 chr15:77176239 SCAPER -0.62 -9.61 -0.47 1.83e-19 Blood metabolite levels; LUSC cis rs1950626 0.743 rs12887333 chr14:101462612 C/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.36 5.87 0.31 1.06e-8 Pelvic organ prolapse (moderate/severe); LUSC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg22655196 chr4:3374909 RGS12 0.3 5.71 0.3 2.53e-8 Serum sulfate level; LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg24060327 chr5:131705240 SLC22A5 -0.67 -11.47 -0.53 6.61e-26 Breast cancer; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg06145435 chr7:1022769 CYP2W1 0.33 7.35 0.37 1.55e-12 Longevity;Endometriosis; LUSC cis rs10779751 1.000 rs6679878 chr1:11306882 A/G cg08854313 chr1:11322531 MTOR 0.87 15.01 0.63 2.81e-39 Body mass index; LUSC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg00383909 chr3:49044727 WDR6 0.42 5.64 0.3 3.58e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg19230755 chr7:65878503 NA -0.43 -6.01 -0.31 4.8e-9 Aortic root size; LUSC cis rs7954584 0.505 rs11043278 chr12:122412145 C/T cg21016266 chr12:122356598 WDR66 0.6 8.77 0.43 9.2e-17 Mean corpuscular volume; LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs4664304 0.966 rs925407 chr2:160767502 A/C cg03641300 chr2:160917029 PLA2R1 -0.4 -6.69 -0.34 9.18e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg04287289 chr16:89883240 FANCA 0.8 14.0 0.61 2.4e-35 Vitiligo; LUSC cis rs11214589 0.747 rs11493880 chr11:113225144 C/T cg14159747 chr11:113255604 NA 0.24 5.9 0.31 8.99e-9 Neuroticism; LUSC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg07701084 chr6:150067640 NUP43 0.56 8.65 0.43 2.26e-16 Lung cancer; LUSC cis rs6933660 0.744 rs35143743 chr6:151768532 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.43 5.71 0.3 2.56e-8 Menarche (age at onset); LUSC cis rs9914988 0.943 rs9908881 chr17:27100924 T/A cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2073300 0.609 rs6137913 chr20:23357725 C/T cg12062639 chr20:23401060 NAPB 0.85 7.36 0.37 1.4e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.52 0.59 1.66e-33 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6952808 0.608 rs6461049 chr7:2017445 C/T cg04565464 chr8:145669602 NFKBIL2 -0.4 -6.68 -0.34 9.82e-11 Bipolar disorder and schizophrenia; LUSC cis rs10752881 0.933 rs2027086 chr1:183057933 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.98 0.52 3.62e-24 Colorectal cancer; LUSC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg12963246 chr6:28129442 ZNF389 -0.41 -5.73 -0.3 2.29e-8 Parkinson's disease; LUSC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg12667521 chr19:29218732 NA 0.61 7.51 0.38 5.53e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7918232 0.627 rs6482588 chr10:27308307 G/C cg14240646 chr10:27532245 ACBD5 -0.46 -5.66 -0.3 3.21e-8 Breast cancer; LUSC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg12927641 chr6:109611667 NA -0.43 -7.58 -0.38 3.46e-13 Reticulocyte fraction of red cells; LUSC trans rs9291683 0.588 rs6857693 chr4:10018435 G/A cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Bone mineral density; LUSC cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg12011299 chr4:100065546 ADH4 0.71 10.75 0.51 2.33e-23 Alcohol dependence; LUSC cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg24642439 chr20:33292090 TP53INP2 0.62 9.68 0.47 1.04e-19 Coronary artery disease; LUSC trans rs72674100 1.000 rs17026369 chr4:97989437 C/G cg16405019 chr1:18959625 PAX7 -0.61 -6.44 -0.33 4.04e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs861020 1.000 rs12134698 chr1:209987801 C/A cg05527609 chr1:210001259 C1orf107 -0.93 -12.05 -0.55 5.19e-28 Orofacial clefts; LUSC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg19318889 chr4:1322082 MAEA -0.48 -7.92 -0.4 3.67e-14 Obesity-related traits; LUSC cis rs56399783 0.901 rs17132594 chr7:2775102 G/A cg19731401 chr7:2775893 GNA12 0.7 8.45 0.42 9.01e-16 Childhood ear infection; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.68 0.43 1.76e-16 Prudent dietary pattern; LUSC cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg15395560 chr15:45543142 SLC28A2 0.33 5.71 0.3 2.54e-8 Uric acid levels; LUSC cis rs9905704 0.918 rs302857 chr17:56692387 C/G cg12560992 chr17:57184187 TRIM37 0.55 7.87 0.4 5.02e-14 Testicular germ cell tumor; LUSC cis rs9527 0.590 rs7910900 chr10:104829898 C/T cg04362960 chr10:104952993 NT5C2 0.63 9.67 0.47 1.13e-19 Arsenic metabolism; LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg16145915 chr7:1198662 ZFAND2A -0.51 -9.93 -0.48 1.57e-20 Longevity;Endometriosis; LUSC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg21724239 chr8:58056113 NA -0.79 -9.27 -0.45 2.32e-18 Developmental language disorder (linguistic errors); LUSC cis rs10088262 0.629 rs7833650 chr8:124822969 C/T cg20713898 chr8:124780851 FAM91A1 -0.55 -7.53 -0.38 4.81e-13 Pancreatic cancer; LUSC cis rs2130392 0.924 rs873687 chr4:185638853 G/A cg21366198 chr4:185655624 MLF1IP 0.41 5.83 0.3 1.29e-8 Kawasaki disease; LUSC cis rs10992471 0.603 rs1535755 chr9:95202031 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -7.89 -0.4 4.36e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs12421382 0.614 rs11213102 chr11:109385853 G/A cg11473876 chr11:109292803 C11orf87 0.35 5.9 0.31 8.93e-9 Schizophrenia; LUSC trans rs2727020 0.595 rs10839281 chr11:49483373 A/C cg15704280 chr7:45808275 SEPT13 -1.1 -22.16 -0.77 1.46e-67 Coronary artery disease; LUSC cis rs7945705 0.869 rs4909952 chr11:8963946 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.39 8.38 0.42 1.52e-15 Hemoglobin concentration; LUSC cis rs9527 0.590 rs1926029 chr10:104855670 C/T cg05855489 chr10:104503620 C10orf26 0.5 7.65 0.39 2.19e-13 Arsenic metabolism; LUSC cis rs4631830 0.720 rs2125771 chr10:51506957 C/T cg20129853 chr10:51489980 NA -0.36 -7.58 -0.38 3.5e-13 Prostate-specific antigen levels; LUSC cis rs453301 0.624 rs2915251 chr8:8867411 G/C cg08975724 chr8:8085496 FLJ10661 0.49 7.05 0.36 1.02e-11 Joint mobility (Beighton score); LUSC cis rs10504073 0.584 rs55795863 chr8:49898055 A/G cg00325661 chr8:49890786 NA 0.71 11.05 0.52 2.08e-24 Blood metabolite ratios; LUSC cis rs7659604 0.540 rs7699289 chr4:122671553 G/A cg19748678 chr4:122722346 EXOSC9 -0.43 -6.37 -0.33 6.4e-10 Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19709743 chr11:118230230 UBE4A -0.41 -6.62 -0.34 1.44e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs675209 0.637 rs1285879 chr6:7137363 T/C cg23726566 chr6:7051754 NA -0.36 -5.67 -0.3 3.07e-8 Urate levels; LUSC trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.55 -7.75 -0.39 1.1e-13 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg22638593 chr5:131593259 PDLIM4 0.42 6.32 0.33 8.15e-10 Blood metabolite levels; LUSC trans rs9329221 0.662 rs11249996 chr8:10245463 G/T cg15556689 chr8:8085844 FLJ10661 -0.66 -9.67 -0.47 1.13e-19 Neuroticism; LUSC cis rs7267979 0.739 rs6138555 chr20:25242910 G/A cg08601574 chr20:25228251 PYGB 0.55 8.83 0.43 6.14e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11677370 0.561 rs10084170 chr2:3820204 G/C cg17052675 chr2:3827356 NA -0.65 -10.43 -0.5 3.22e-22 Type 2 diabetes; LUSC cis rs2742417 0.624 rs2673068 chr3:45768981 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.26 -0.37 2.69e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg11584989 chr19:19387371 SF4 0.52 6.31 0.33 8.76e-10 Bipolar disorder; LUSC trans rs12200782 1.000 rs12213722 chr6:26473083 A/G cg18180407 chr1:55047736 ACOT11 0.49 6.02 0.31 4.48e-9 Small cell lung carcinoma; LUSC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg02034447 chr16:89574710 SPG7 0.44 6.54 0.34 2.37e-10 Multiple myeloma (IgH translocation); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15820809 chr22:43507369 BIK 0.72 5.97 0.31 6.14e-9 Cognitive performance; LUSC cis rs970548 0.688 rs1059696 chr10:45934437 G/A cg15590007 chr10:45870220 ALOX5 0.51 5.78 0.3 1.7e-8 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg17385448 chr1:15911702 AGMAT 0.36 6.0 0.31 5.18e-9 Systolic blood pressure; LUSC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs6500602 0.767 rs8060219 chr16:4480158 T/A cg08645402 chr16:4508243 NA 0.54 8.97 0.44 2.17e-17 Schizophrenia; LUSC cis rs6500602 0.927 rs7200817 chr16:4480598 G/C cg08645402 chr16:4508243 NA 0.54 9.21 0.45 3.67e-18 Schizophrenia; LUSC cis rs2456568 0.548 rs10501809 chr11:93666263 C/G cg26875233 chr11:93583750 C11orf90 -0.3 -5.75 -0.3 2.05e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC trans rs1814175 0.616 rs28417656 chr11:50040152 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs7945705 0.875 rs10769947 chr11:8758114 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.52 9.97 0.48 1.19e-20 Hemoglobin concentration; LUSC cis rs3818285 0.515 rs12258440 chr10:111676799 C/T cg00817464 chr10:111662876 XPNPEP1 -0.64 -9.44 -0.46 6.49e-19 Superior crus of antihelix expression; LUSC trans rs2018683 0.624 rs1006521 chr7:28996220 G/A cg19402173 chr7:128379420 CALU -0.52 -7.75 -0.39 1.08e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs8179 0.514 rs11773884 chr7:92285123 A/G cg15732164 chr7:92237376 CDK6 -0.43 -6.45 -0.33 3.92e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.67 -11.53 -0.53 3.96e-26 IgG glycosylation; LUSC cis rs7474896 0.583 rs10827817 chr10:37997974 A/G cg25427524 chr10:38739819 LOC399744 -0.51 -7.21 -0.37 3.79e-12 Obesity (extreme); LUSC trans rs7824557 0.527 rs4631425 chr8:11239054 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.64 -0.39 2.39e-13 Retinal vascular caliber; LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg05368731 chr17:41323189 NBR1 0.93 16.11 0.66 1.32e-43 Menopause (age at onset); LUSC cis rs4555082 1.000 rs4334224 chr14:105759198 C/T cg13114125 chr14:105738426 BRF1 -0.86 -14.21 -0.61 3.63e-36 Mean platelet volume;Platelet distribution width; LUSC cis rs7954584 0.583 rs6486782 chr12:122359172 T/C cg10207240 chr12:122356781 WDR66 0.44 6.19 0.32 1.72e-9 Mean corpuscular volume; LUSC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg25554036 chr4:6271136 WFS1 0.51 9.15 0.45 5.87e-18 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6088590 0.550 rs12624640 chr20:32952125 G/A cg24642439 chr20:33292090 TP53INP2 0.57 8.15 0.41 7.49e-15 Coronary artery disease; LUSC cis rs4285028 0.948 rs35415993 chr3:121669236 C/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.54 -0.46 3.19e-19 Multiple sclerosis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20297566 chr3:99979976 TBC1D23 -0.43 -6.14 -0.32 2.31e-9 Hepatitis; LUSC trans rs10435719 0.867 rs62493601 chr8:11788307 C/T cg14343924 chr8:8086146 FLJ10661 0.44 6.12 0.32 2.63e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4144743 0.528 rs16941802 chr17:45355353 C/G cg18085866 chr17:45331354 ITGB3 0.7 6.06 0.31 3.65e-9 Body mass index; LUSC cis rs12760731 0.777 rs6701080 chr1:178382261 A/C cg00404053 chr1:178313656 RASAL2 0.64 6.52 0.34 2.59e-10 Obesity-related traits; LUSC cis rs7561273 0.609 rs2339945 chr2:24348096 G/A cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC trans rs9329221 0.935 rs3750310 chr8:10283426 G/A cg15556689 chr8:8085844 FLJ10661 -0.6 -8.94 -0.44 2.76e-17 Neuroticism; LUSC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg21573476 chr21:45109991 RRP1B -0.37 -6.0 -0.31 5.14e-9 Mean corpuscular volume; LUSC cis rs7903847 0.642 rs2297667 chr10:99145492 A/T cg08345082 chr10:99160200 RRP12 -0.36 -7.3 -0.37 2.08e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7843479 0.828 rs4357289 chr8:21777476 G/A cg17168535 chr8:21777572 XPO7 0.69 10.67 0.5 4.55e-23 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs11122272 0.735 rs2256908 chr1:231506557 G/A cg06096015 chr1:231504339 EGLN1 0.57 10.07 0.48 5.37e-21 Hemoglobin concentration; LUSC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs5769707 0.967 rs4524218 chr22:50018639 G/A cg20744362 chr22:50050164 C22orf34 0.4 8.33 0.41 2.15e-15 Monocyte count;Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01511126 chr1:40506125 CAP1 0.48 7.27 0.37 2.56e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4689388 0.856 rs1046314 chr4:6303955 A/G cg17567195 chr5:167378696 ODZ2 0.37 6.03 0.31 4.4e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs9359856 0.564 rs72913975 chr6:90387116 C/T cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.89 -0.44 3.8e-17 Bipolar disorder; LUSC cis rs9790314 0.690 rs7651087 chr3:160821929 T/C cg03342759 chr3:160939853 NMD3 -0.42 -6.78 -0.35 5.43e-11 Morning vs. evening chronotype; LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg08859206 chr1:53392774 SCP2 -0.66 -12.58 -0.57 5.43e-30 Monocyte count; LUSC cis rs9875589 0.509 rs7651599 chr3:14010974 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.36 6.26 0.32 1.19e-9 Ovarian reserve; LUSC trans rs853679 0.517 rs9380049 chr6:28048535 A/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs7914558 0.966 rs746293 chr10:104897254 G/T cg23093090 chr10:104574429 C10orf26 -0.38 -7.09 -0.36 8.04e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg04352962 chr1:209979756 IRF6 -0.52 -6.03 -0.31 4.24e-9 Cleft lip with or without cleft palate; LUSC trans rs2235573 0.551 rs139892 chr22:38388203 C/T cg19894588 chr14:64061835 NA 0.49 7.05 0.36 1.05e-11 Glioblastoma;Glioma; LUSC cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs4363385 0.791 rs372490 chr1:153008971 A/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg00852783 chr1:26633632 UBXN11 0.61 9.66 0.47 1.28e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs1559088 0.895 rs1974784 chr19:33551563 T/G cg03563238 chr19:33554763 RHPN2 -0.4 -6.45 -0.33 3.95e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9457247 0.905 rs444210 chr6:167390242 A/G cg23791538 chr6:167370224 RNASET2 -0.41 -6.76 -0.35 6.24e-11 Crohn's disease; LUSC cis rs2692947 0.759 rs2692937 chr2:96751871 G/A cg23100626 chr2:96804247 ASTL 0.31 7.52 0.38 5.05e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg25173405 chr17:45401733 C17orf57 0.36 5.73 0.3 2.26e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs78707713 0.560 rs61848397 chr10:71225584 C/A cg14388049 chr10:71211838 TSPAN15 -0.33 -5.84 -0.3 1.22e-8 Venous thromboembolism; LUSC cis rs2387326 0.717 rs12252256 chr10:129944616 C/T cg16087940 chr10:129947807 NA -0.41 -6.22 -0.32 1.51e-9 Select biomarker traits; LUSC cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22857025 chr5:266934 NA -1.18 -14.3 -0.62 1.62e-36 Breast cancer; LUSC cis rs9297145 0.761 rs62473015 chr7:98763301 G/A cg05967295 chr7:98741636 SMURF1 0.95 13.67 0.6 4.25e-34 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs66887589 0.616 rs6822808 chr4:120217365 C/A cg09307838 chr4:120376055 NA 0.53 7.97 0.4 2.62e-14 Diastolic blood pressure; LUSC cis rs7528419 1.000 rs629301 chr1:109818306 G/T cg00908766 chr1:109817496 CELSR2 0.71 11.64 0.54 1.58e-26 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; LUSC trans rs800082 1.000 rs11718059 chr3:144305997 G/A cg24215973 chr2:240111563 HDAC4 -0.46 -6.93 -0.35 2.24e-11 Smoking behavior; LUSC cis rs11690935 0.921 rs908670 chr2:172690180 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.43 -0.62 5.22e-37 Schizophrenia; LUSC cis rs7399018 0.739 rs7399073 chr12:51614050 C/A cg25754956 chr12:51612065 POU6F1 1.02 16.72 0.67 5.25e-46 Cisplatin-induced ototoxicity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17680823 chr2:240016541 HDAC4 0.45 6.6 0.34 1.66e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg25643088 chr3:52874325 TMEM110 -0.39 -5.84 -0.3 1.25e-8 Schizophrenia; LUSC cis rs11048434 0.736 rs2377673 chr12:9112551 A/G cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC cis rs10392 0.543 rs59777567 chr20:37557548 A/G cg27552599 chr20:37590471 DHX35 0.43 6.86 0.35 3.3e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg14440974 chr22:39074834 NA -0.38 -6.26 -0.32 1.15e-9 Menopause (age at onset); LUSC cis rs2404602 0.684 rs8037847 chr15:76856551 C/T cg23625390 chr15:77176239 SCAPER -0.67 -10.28 -0.49 9.91e-22 Blood metabolite levels; LUSC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg08859206 chr1:53392774 SCP2 -0.47 -7.8 -0.39 8e-14 Monocyte count; LUSC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 14.03 0.61 1.79e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6690583 0.623 rs61768852 chr1:85454613 T/C cg22153463 chr1:85462885 MCOLN2 0.62 6.0 0.31 5.12e-9 Serum sulfate level; LUSC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg11871910 chr12:69753446 YEATS4 0.94 17.4 0.69 1.05e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg21951975 chr1:209979733 IRF6 0.4 6.63 0.34 1.32e-10 Monobrow; LUSC cis rs4285028 0.747 rs7610298 chr3:121419100 T/A cg11130432 chr3:121712080 ILDR1 -0.53 -7.84 -0.39 6.07e-14 Multiple sclerosis; LUSC cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg23711669 chr6:146136114 FBXO30 0.82 14.87 0.63 9.54e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg12311346 chr5:56204834 C5orf35 -0.89 -12.81 -0.57 7.52e-31 Initial pursuit acceleration; LUSC cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs10504073 0.584 rs56134839 chr8:49918899 C/T cg00325661 chr8:49890786 NA 0.7 11.08 0.52 1.6e-24 Blood metabolite ratios; LUSC cis rs9309473 0.519 rs1815027 chr2:73831840 T/C cg20560298 chr2:73613845 ALMS1 0.48 7.38 0.37 1.31e-12 Metabolite levels; LUSC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg05855489 chr10:104503620 C10orf26 -0.76 -13.08 -0.58 7.59e-32 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs3799378 0.579 rs9348715 chr6:26375642 C/G cg09904177 chr6:26538194 HMGN4 -0.45 -6.4 -0.33 5.33e-10 Intelligence (multi-trait analysis); LUSC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg12564285 chr5:131593104 PDLIM4 -0.47 -7.65 -0.39 2.21e-13 Breast cancer; LUSC trans rs2243480 1.000 rs781142 chr7:65438778 C/T cg10756647 chr7:56101905 PSPH 0.85 8.34 0.42 2.04e-15 Diabetic kidney disease; LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.64 -9.86 -0.47 2.78e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9303542 0.559 rs1042822 chr17:46620095 G/T cg09704116 chr17:46666958 LOC404266 -0.38 -6.54 -0.34 2.34e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg02269571 chr22:50332266 NA -0.55 -8.22 -0.41 4.59e-15 Schizophrenia; LUSC cis rs10876993 0.890 rs1689584 chr12:58081478 G/A cg18357645 chr12:58087776 OS9 0.58 8.82 0.43 6.45e-17 Celiac disease or Rheumatoid arthritis; LUSC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg16423285 chr20:60520624 NA -0.63 -8.03 -0.4 1.69e-14 Body mass index; LUSC cis rs8060686 0.516 rs2290700 chr16:68288983 T/G cg05110241 chr16:68378359 PRMT7 -0.53 -6.59 -0.34 1.75e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg05081339 chr9:140082886 ANAPC2;SSNA1 0.39 6.15 0.32 2.19e-9 Schizophrenia; LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg02086790 chr16:375327 AXIN1 -0.38 -5.88 -0.31 1.01e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg03233332 chr7:66118400 NA 0.38 5.81 0.3 1.43e-8 Aortic root size; LUSC cis rs7980687 0.550 rs1727324 chr12:123698603 A/T cg13010344 chr12:123464640 ARL6IP4 -0.48 -5.9 -0.31 8.74e-9 Height;Educational attainment;Head circumference (infant); LUSC cis rs782590 0.721 rs782641 chr2:55929294 C/T cg03859395 chr2:55845619 SMEK2 0.82 14.08 0.61 1.15e-35 Metabolic syndrome; LUSC cis rs16867321 0.950 rs1919148 chr2:181501758 G/A cg23363182 chr2:181467187 NA -0.45 -5.92 -0.31 7.98e-9 Obesity; LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg27170947 chr2:26402098 FAM59B -0.69 -10.55 -0.5 1.2e-22 Gut microbiome composition (summer); LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg26659404 chr1:25747437 RHCE -0.28 -5.73 -0.3 2.19e-8 Erythrocyte sedimentation rate; LUSC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg13206674 chr6:150067644 NUP43 0.62 10.17 0.49 2.43e-21 Lung cancer; LUSC cis rs7592578 0.771 rs75579212 chr2:191376575 C/T cg11845111 chr2:191398756 TMEM194B -0.87 -11.13 -0.52 1.11e-24 Diastolic blood pressure; LUSC cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.46 -8.69 -0.43 1.64e-16 Monocyte percentage of white cells; LUSC cis rs9309473 0.555 rs2901437 chr2:73597024 T/G cg20560298 chr2:73613845 ALMS1 -0.53 -7.81 -0.39 7.72e-14 Metabolite levels; LUSC cis rs17780086 0.527 rs72827712 chr17:30538600 A/G cg00745463 chr17:30367425 LRRC37B -0.83 -7.9 -0.4 4e-14 Height; LUSC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.88 -0.35 3.04e-11 Mean platelet volume; LUSC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg02773041 chr1:40204384 PPIE 0.51 7.47 0.38 7.16e-13 Blood protein levels; LUSC cis rs2708377 0.872 rs2708323 chr12:11198433 A/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC trans rs2926702 0.810 rs16936761 chr8:71051850 C/A cg16517358 chr11:46164796 NA 0.39 6.18 0.32 1.9e-9 Non-small cell lung cancer; LUSC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg07741184 chr6:167504864 NA -0.35 -6.28 -0.33 1.04e-9 Crohn's disease; LUSC cis rs983392 0.836 rs17602572 chr11:59948374 C/G cg24026212 chr11:59952134 MS4A6A -0.38 -6.63 -0.34 1.39e-10 Alzheimer's disease (late onset); LUSC cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg14196790 chr5:131705035 SLC22A5 0.48 8.13 0.41 8.53e-15 Blood metabolite levels; LUSC cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.44 0.5 2.97e-22 Bladder cancer; LUSC cis rs977987 0.645 rs34904236 chr16:75498253 G/T cg04384234 chr16:75411784 CFDP1 -0.48 -7.9 -0.4 4.01e-14 Dupuytren's disease; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg06784260 chr12:69634187 CPSF6 0.42 6.27 0.32 1.1e-9 Metabolite levels (Pyroglutamine); LUSC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg26408565 chr15:76604113 ETFA -0.51 -8.13 -0.41 8.37e-15 Blood metabolite levels; LUSC cis rs62408225 1.000 rs1604831 chr6:90967197 G/A cg06866423 chr6:90926672 BACH2 0.4 5.82 0.3 1.37e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1322512 0.958 rs74608294 chr6:152944818 T/C cg27316956 chr6:152958899 SYNE1 -0.33 -5.66 -0.3 3.25e-8 Tonometry; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg00166722 chr3:10149974 C3orf24 0.56 7.54 0.38 4.61e-13 Alzheimer's disease; LUSC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11890956 chr21:40555474 PSMG1 1.04 21.0 0.75 5.16e-63 Cognitive function; LUSC cis rs12681288 0.523 rs11137122 chr8:954702 A/G cg04851639 chr8:1020857 NA -0.35 -7.15 -0.36 5.6e-12 Schizophrenia; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.04 -0.4 1.57e-14 Lymphocyte counts; LUSC cis rs9814567 1.000 rs9834755 chr3:134206845 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.85 -14.32 -0.62 1.3e-36 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7824557 0.620 rs6996368 chr8:11182704 G/A cg21293242 chr8:11204541 TDH 0.31 5.92 0.31 7.88e-9 Retinal vascular caliber; LUSC cis rs7107174 0.901 rs1055248 chr11:77925573 T/C cg02023728 chr11:77925099 USP35 0.53 7.59 0.38 3.24e-13 Testicular germ cell tumor; LUSC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg15369054 chr17:80825471 TBCD 0.71 11.94 0.55 1.34e-27 Breast cancer; LUSC cis rs7666738 0.609 rs28833816 chr4:98868866 T/C cg05340658 chr4:99064831 C4orf37 0.59 8.73 0.43 1.28e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs12900413 0.959 rs12908026 chr15:90318884 C/T cg24249390 chr15:90295951 MESP1 -0.46 -6.75 -0.35 6.64e-11 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs6987853 0.712 rs2974343 chr8:42400679 G/A cg09913449 chr8:42400586 C8orf40 0.54 9.31 0.45 1.7e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs5167 0.781 rs11672748 chr19:45490192 A/G cg20090143 chr19:45452003 APOC2 0.35 5.9 0.31 9.14e-9 Blood protein levels; LUSC cis rs3850699 0.683 rs67481356 chr10:104317811 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.77 -0.3 1.82e-8 Prostate cancer; LUSC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs1371867 0.810 rs1618528 chr8:101259134 T/C cg06636551 chr8:101224915 SPAG1 0.43 7.89 0.4 4.24e-14 Atrioventricular conduction; LUSC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.21 0.45 3.72e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs9467773 1.000 rs9467787 chr6:26556769 G/T cg09904177 chr6:26538194 HMGN4 0.76 14.16 0.61 5.54e-36 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg24531977 chr5:56204891 C5orf35 -0.99 -15.1 -0.64 1.26e-39 Initial pursuit acceleration; LUSC cis rs992157 0.735 rs2271541 chr2:219082119 G/T cg00012203 chr2:219082015 ARPC2 0.89 17.23 0.69 4.95e-48 Colorectal cancer; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg15790184 chr11:494944 RNH1 0.54 6.08 0.32 3.37e-9 Body mass index; LUSC cis rs2011503 1.000 rs1036215 chr19:19657198 C/T cg11584989 chr19:19387371 SF4 0.56 6.32 0.33 8.54e-10 Bipolar disorder; LUSC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.42 0.33 4.63e-10 Cerebrospinal P-tau181p levels; LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg24060327 chr5:131705240 SLC22A5 -0.53 -8.78 -0.43 8.48e-17 Acylcarnitine levels; LUSC cis rs11209002 0.614 rs10732837 chr1:67573120 A/G cg02640540 chr1:67518911 SLC35D1 0.61 8.53 0.42 5.03e-16 Crohn's disease; LUSC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs2816062 0.786 rs2816055 chr1:18898248 A/G cg18795169 chr1:18902165 NA -1.01 -24.65 -0.8 3.53e-77 Urate levels in lean individuals; LUSC cis rs7512552 0.839 rs3896342 chr1:150411312 T/C cg15654264 chr1:150340011 RPRD2 0.66 10.9 0.51 7.07e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.73 -0.35 7.2e-11 Monocyte percentage of white cells; LUSC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg06219351 chr7:158114137 PTPRN2 -0.54 -8.36 -0.42 1.71e-15 Response to amphetamines; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21577651 chr17:6939140 SLC16A13 0.47 6.44 0.33 4.19e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12122100 0.651 rs12737860 chr1:146546343 G/T cg03526459 chr1:146549940 NA -0.4 -6.49 -0.33 3.18e-10 HIV-1 control; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg06513149 chr13:33002431 N4BP2L1 -0.42 -6.07 -0.32 3.54e-9 Hepatitis; LUSC cis rs9399137 0.507 rs7771310 chr6:135272535 G/A cg22676075 chr6:135203613 NA 0.62 9.68 0.47 1.04e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs611744 0.647 rs585077 chr8:109245497 C/T cg18478394 chr8:109455254 TTC35 0.41 6.32 0.33 8.55e-10 Dupuytren's disease; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg08736216 chr1:53307985 ZYG11A -0.29 -6.0 -0.31 5.15e-9 Monocyte count; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg08859206 chr1:53392774 SCP2 -0.59 -11.0 -0.52 3.07e-24 Monocyte count; LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.08 0.4 1.17e-14 Prudent dietary pattern; LUSC cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14442939 chr10:27389572 ANKRD26 0.9 9.49 0.46 4.38e-19 Breast cancer; LUSC cis rs701145 0.586 rs355785 chr3:153990251 T/G cg17054900 chr3:154042577 DHX36 0.82 8.52 0.42 5.56e-16 Coronary artery disease; LUSC cis rs10754283 0.967 rs10922679 chr1:90100925 T/C cg21401794 chr1:90099060 LRRC8C 0.65 9.9 0.48 1.98e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg26513180 chr16:89883248 FANCA 0.9 17.26 0.69 3.48e-48 Vitiligo; LUSC cis rs2273669 0.667 rs4527738 chr6:109309150 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs2073300 0.609 rs6137929 chr20:23376357 G/A cg12062639 chr20:23401060 NAPB 0.93 8.06 0.4 1.33e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg19077165 chr18:44547161 KATNAL2 -0.37 -5.72 -0.3 2.33e-8 Personality dimensions; LUSC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.89 0.31 9.24e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg03289416 chr15:75166202 SCAMP2 0.45 6.76 0.35 6.11e-11 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08063194 chr16:20817608 ERI2;LOC81691 -0.4 -6.01 -0.31 4.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.39 0.67 1.04e-44 Platelet count; LUSC cis rs10751667 0.666 rs10902248 chr11:957742 A/G ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.13e-10 Alzheimer's disease (late onset); LUSC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg06238570 chr21:40685208 BRWD1 0.47 7.3 0.37 2.12e-12 Cognitive function; LUSC cis rs4631830 0.900 rs10763576 chr10:51538813 A/T cg16070123 chr10:51489643 NA -0.47 -7.39 -0.37 1.23e-12 Prostate-specific antigen levels; LUSC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg06636001 chr8:8085503 FLJ10661 0.86 14.65 0.63 7.19e-38 Neuroticism; LUSC cis rs9325144 0.723 rs11169519 chr12:39177441 G/A cg13010199 chr12:38710504 ALG10B -0.49 -7.56 -0.38 3.84e-13 Morning vs. evening chronotype; LUSC cis rs4268898 0.735 rs12469585 chr2:24489054 A/T cg06627628 chr2:24431161 ITSN2 0.59 8.47 0.42 7.65e-16 Asthma; LUSC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg09034736 chr1:150693464 HORMAD1 0.46 6.76 0.35 6.02e-11 Tonsillectomy; LUSC cis rs6442522 0.867 rs12637268 chr3:15500248 T/C cg16303742 chr3:15540471 COLQ 0.3 5.94 0.31 7.09e-9 Uric acid levels; LUSC cis rs262150 0.579 rs4481540 chr7:158785846 A/G cg19418458 chr7:158789849 NA 0.52 6.9 0.35 2.61e-11 Facial morphology (factor 20); LUSC cis rs12579753 1.000 rs10862371 chr12:82249298 C/T cg07988820 chr12:82153109 PPFIA2 -0.41 -5.7 -0.3 2.68e-8 Resting heart rate; LUSC cis rs8114671 0.967 rs2069952 chr20:33763951 C/T cg07148914 chr20:33460835 GGT7 0.47 6.93 0.35 2.22e-11 Height; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.26 0.52 3.81e-25 Prudent dietary pattern; LUSC cis rs9467711 0.659 rs13195509 chr6:26463660 C/T cg09904177 chr6:26538194 HMGN4 -0.78 -6.38 -0.33 5.92e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs17270561 0.609 rs1165156 chr6:25792978 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 6.56 0.34 2.02e-10 Iron status biomarkers; LUSC cis rs9658691 0.607 rs12416581 chr10:90780440 C/T cg03111039 chr10:90751583 FAS;ACTA2 -0.55 -5.92 -0.31 8.12e-9 Mosquito bite size; LUSC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg05340658 chr4:99064831 C4orf37 0.65 11.03 0.52 2.39e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs11676348 0.811 rs4674255 chr2:218987325 C/T cg00012203 chr2:219082015 ARPC2 -0.56 -8.99 -0.44 1.83e-17 Ulcerative colitis; LUSC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.43 0.38 9.18e-13 Menarche (age at onset); LUSC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg02534363 chr3:47050950 NBEAL2 0.36 5.84 0.3 1.26e-8 Colorectal cancer; LUSC cis rs739401 0.572 rs389128 chr11:3083873 G/T cg08508325 chr11:3079039 CARS -0.52 -12.66 -0.57 2.91e-30 Longevity; LUSC cis rs28647808 0.881 rs57394597 chr9:136261030 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs6667605 0.527 rs12046118 chr1:2540343 A/C cg18854424 chr1:2615690 NA 0.52 10.79 0.51 1.71e-23 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg19418458 chr7:158789849 NA -0.65 -10.41 -0.49 3.69e-22 Facial morphology (factor 20); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14671666 chr5:41904456 C5orf51 -0.39 -6.3 -0.33 9.18e-10 Electrocardiographic conduction measures; LUSC cis rs77216612 0.835 rs56692845 chr12:12887811 C/T cg09462578 chr12:12878428 APOLD1 -0.99 -16.97 -0.68 5.06e-47 Lymphocyte counts; LUSC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg23303369 chr20:44641161 MMP9 0.35 6.07 0.32 3.47e-9 Intelligence (multi-trait analysis); LUSC trans rs13011075 0.919 rs56188212 chr2:68611631 T/C cg14221825 chr19:46271408 SIX5 0.42 6.06 0.31 3.74e-9 Mean corpuscular volume; LUSC cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg19628046 chr18:33552617 C18orf21 0.51 6.1 0.32 2.94e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg09085632 chr11:111637200 PPP2R1B -1.09 -17.41 -0.69 9.58e-49 Primary sclerosing cholangitis; LUSC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.76 0.39 1.03e-13 Electroencephalogram traits; LUSC cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.94 0.4 3.18e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7043114 0.544 rs7852510 chr9:95316359 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.49 -0.33 3.02e-10 Height; LUSC cis rs9467773 0.596 rs2451750 chr6:26646579 A/T cg05738196 chr6:26577821 NA 0.78 14.89 0.63 7.91e-39 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.28 0.32 1.07e-9 Platelet count; LUSC cis rs3862435 0.572 rs2601165 chr15:90908934 C/G cg22089800 chr15:90895588 ZNF774 -0.57 -6.32 -0.33 8.61e-10 Response to exercise (triglyceride level interaction); LUSC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs780096 0.526 rs11682621 chr2:27749669 G/A cg22903471 chr2:27725779 GCKR -0.38 -6.34 -0.33 7.45e-10 Total body bone mineral density; LUSC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg03605463 chr16:89740564 NA 0.6 9.43 0.46 6.96e-19 Vitiligo; LUSC cis rs9650315 0.530 rs61334940 chr8:57072570 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.56 8.57 0.42 3.89e-16 Height; LUSC cis rs1775715 0.737 rs2778650 chr10:32106851 A/G cg03015672 chr10:32216066 ARHGAP12 0.33 5.84 0.3 1.22e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2070433 0.706 rs55696586 chr21:47733918 T/C cg12379764 chr21:47803548 PCNT 0.73 8.47 0.42 7.72e-16 Lymphocyte counts; LUSC cis rs2274273 0.588 rs7154831 chr14:55823965 A/C cg04306507 chr14:55594613 LGALS3 0.48 9.81 0.47 3.89e-20 Protein biomarker; LUSC trans rs61931739 0.649 rs815037 chr12:33725193 C/T cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg14664628 chr15:75095509 CSK -0.48 -6.93 -0.35 2.22e-11 Breast cancer; LUSC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg25233709 chr10:116636983 FAM160B1 0.44 7.89 0.4 4.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs7617480 0.616 rs9873227 chr3:48773108 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.65 9.66 0.47 1.25e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg06238570 chr21:40685208 BRWD1 -0.53 -8.19 -0.41 5.67e-15 Menarche (age at onset); LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.71 0.54 9.03e-27 Prudent dietary pattern; LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg09877947 chr5:131593287 PDLIM4 -0.46 -6.88 -0.35 3.01e-11 Blood metabolite levels; LUSC cis rs4938330 0.629 rs12269901 chr11:116973929 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.47 -6.15 -0.32 2.2e-9 Blood protein levels; LUSC cis rs4629710 0.592 rs67399092 chr6:131582936 G/A cg12606694 chr6:131520996 AKAP7 0.63 9.57 0.46 2.49e-19 Multiple myeloma (IgH translocation); LUSC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.5 -0.33 2.98e-10 Breast cancer; LUSC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg04155289 chr7:94953770 PON1 -0.36 -5.91 -0.31 8.42e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs73206853 0.686 rs73194018 chr12:111127697 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 6.73 0.35 7.61e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg23978390 chr7:1156363 C7orf50 0.48 5.65 0.3 3.49e-8 Bronchopulmonary dysplasia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg07118243 chr12:94853994 CCDC41;LOC144486 0.42 6.26 0.32 1.16e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 7.89 0.4 4.31e-14 Chronic sinus infection; LUSC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg21285383 chr16:89894308 SPIRE2 0.33 7.0 0.36 1.44e-11 Vitiligo; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg13560548 chr3:10150139 C3orf24 0.54 7.2 0.37 4.05e-12 Alzheimer's disease; LUSC trans rs4942242 0.663 rs1472330 chr13:44209628 A/G cg19169023 chr15:41853346 TYRO3 0.58 8.96 0.44 2.39e-17 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10551759 chr7:121036528 FAM3C -0.4 -6.04 -0.31 4.2e-9 Electrocardiographic conduction measures; LUSC cis rs1018836 0.847 rs4735226 chr8:91569238 T/A cg16814680 chr8:91681699 NA -0.76 -12.82 -0.57 7.37e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9814567 1.000 rs6782563 chr3:134295959 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 13.55 0.6 1.2e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1801251 1.000 rs4973054 chr2:233710713 G/C cg25237894 chr2:233734115 C2orf82 -0.37 -6.92 -0.35 2.31e-11 Coronary artery disease; LUSC trans rs10256972 0.630 rs13235747 chr7:1129123 T/C cg13565492 chr6:43139072 SRF -0.41 -6.07 -0.32 3.43e-9 Longevity;Endometriosis; LUSC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg20203395 chr5:56204925 C5orf35 -0.74 -9.97 -0.48 1.14e-20 Initial pursuit acceleration; LUSC cis rs2285947 0.967 rs2285948 chr7:21584229 T/C cg04471919 chr7:21584483 DNAH11 0.34 7.73 0.39 1.29e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg17211192 chr8:82754475 SNX16 -0.59 -8.48 -0.42 7.62e-16 Diastolic blood pressure; LUSC cis rs11785400 0.793 rs4301430 chr8:143737416 A/G cg24634471 chr8:143751801 JRK 0.52 7.23 0.37 3.26e-12 Schizophrenia; LUSC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.81 -0.3 1.49e-8 Total body bone mineral density; LUSC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg06713675 chr4:122721982 EXOSC9 -0.7 -11.97 -0.55 1.02e-27 Type 2 diabetes; LUSC cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.1 0.48 4.15e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg04025307 chr7:1156635 C7orf50 0.55 8.48 0.42 7.47e-16 Longevity;Endometriosis; LUSC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg21724239 chr8:58056113 NA 0.56 6.92 0.35 2.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs6565180 0.926 rs4788409 chr16:30393771 G/A cg17640201 chr16:30407289 ZNF48 0.9 15.41 0.64 7.41e-41 Tonsillectomy; LUSC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs806215 1.000 rs712698 chr7:127249098 C/T cg25922125 chr7:127225783 GCC1 0.57 7.17 0.37 4.96e-12 Type 2 diabetes; LUSC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg24675056 chr1:15929824 NA 0.46 8.02 0.4 1.83e-14 Systolic blood pressure; LUSC trans rs2204008 0.776 rs8186824 chr12:38316537 A/C cg06521331 chr12:34319734 NA -0.41 -6.35 -0.33 7.12e-10 Bladder cancer; LUSC cis rs7191700 0.509 rs416603 chr16:11364079 A/T cg00044050 chr16:11439710 C16orf75 -0.6 -10.18 -0.49 2.29e-21 Multiple sclerosis; LUSC trans rs7746199 0.736 rs67652222 chr6:27586220 C/T cg06606381 chr12:133084897 FBRSL1 -0.97 -8.98 -0.44 1.96e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs12540874 0.698 rs10899736 chr7:50546925 C/T cg18232548 chr7:50535776 DDC -0.64 -9.7 -0.47 9.04e-20 Systemic sclerosis; LUSC cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg02527881 chr3:46936655 PTH1R 0.39 6.95 0.36 1.9e-11 Colorectal cancer; LUSC cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg22676075 chr6:135203613 NA 0.59 9.42 0.46 7.88e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg10909506 chr17:38081995 ORMDL3 0.34 5.89 0.31 9.49e-9 Self-reported allergy; LUSC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.18 -0.32 1.84e-9 Alzheimer's disease (late onset); LUSC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg12365402 chr11:9010492 NRIP3 -0.47 -8.82 -0.43 6.25e-17 Hemoglobin concentration; LUSC cis rs6598955 0.724 rs869683 chr1:26570993 T/A cg04990556 chr1:26633338 UBXN11 -0.8 -14.89 -0.63 8.42e-39 Obesity-related traits; LUSC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg02782426 chr3:40428986 ENTPD3 0.34 6.72 0.35 7.92e-11 Renal cell carcinoma; LUSC cis rs8114671 0.836 rs2425012 chr20:33581955 G/A cg24642439 chr20:33292090 TP53INP2 -0.43 -6.14 -0.32 2.39e-9 Height; LUSC cis rs2652834 0.851 rs7170462 chr15:63345622 A/G cg05507819 chr15:63340323 TPM1 0.67 8.52 0.42 5.72e-16 HDL cholesterol; LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg13397359 chr6:42928475 GNMT 0.58 9.56 0.46 2.58e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.59 0.34 1.74e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.83 -0.54 3.32e-27 Chronic sinus infection; LUSC cis rs1801251 0.896 rs921054 chr2:233694673 G/A cg08000102 chr2:233561755 GIGYF2 -0.67 -10.88 -0.51 8.32e-24 Coronary artery disease; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg23034840 chr1:205782522 SLC41A1 0.53 7.37 0.37 1.39e-12 Menarche (age at onset); LUSC cis rs10504229 0.516 rs7821160 chr8:57986281 C/T cg22535103 chr8:58192502 C8orf71 0.46 6.32 0.33 8.16e-10 Developmental language disorder (linguistic errors); LUSC cis rs1215050 0.740 rs1084784 chr4:98961711 T/G cg05340658 chr4:99064831 C4orf37 -0.47 -7.45 -0.38 7.97e-13 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs11098499 0.955 rs1511015 chr4:120170473 A/C cg25214090 chr10:38739885 LOC399744 0.47 6.86 0.35 3.32e-11 Corneal astigmatism; LUSC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.13 -0.48 3.2e-21 Menarche (age at onset); LUSC cis rs7617480 0.648 rs4858830 chr3:48734002 T/C cg21141812 chr3:48556323 PFKFB4 0.34 6.12 0.32 2.66e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs61931739 0.500 rs6488222 chr12:34526289 G/A cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs6582630 0.593 rs11182590 chr12:38574274 A/T cg13010199 chr12:38710504 ALG10B 0.53 8.08 0.4 1.16e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs478304 0.580 rs11606947 chr11:65508237 A/C cg05805236 chr11:65401703 PCNXL3 -0.57 -9.37 -0.46 1.11e-18 Acne (severe); LUSC cis rs6686643 0.762 rs9333433 chr1:165611455 G/C cg16553119 chr1:165599451 MGST3 -0.46 -6.49 -0.33 3.07e-10 Total ventricular volume; LUSC cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.51 -7.67 -0.39 1.9e-13 Menarche (age at onset); LUSC cis rs7769051 1.000 rs6934161 chr6:133124077 C/T cg07930552 chr6:133119739 C6orf192 -0.8 -10.5 -0.5 1.78e-22 Type 2 diabetes nephropathy; LUSC cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.44 0.33 4.17e-10 Rheumatoid arthritis; LUSC trans rs7395662 0.591 rs10838968 chr11:48595046 A/G cg21153622 chr11:89784906 NA -0.4 -6.25 -0.32 1.22e-9 HDL cholesterol; LUSC cis rs10751667 0.643 rs10751669 chr11:942344 C/G ch.11.42038R chr11:967971 AP2A2 -0.41 -6.08 -0.32 3.28e-9 Alzheimer's disease (late onset); LUSC cis rs4285028 0.747 rs7647351 chr3:121422109 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.97 -0.58 1.9e-31 Multiple sclerosis; LUSC trans rs61931739 0.500 rs11053140 chr12:34316122 T/C cg26384229 chr12:38710491 ALG10B 0.73 11.89 0.55 2.05e-27 Morning vs. evening chronotype; LUSC cis rs11997175 0.624 rs17700425 chr8:33691467 T/G ch.8.33884649F chr8:33765107 NA 0.47 6.98 0.36 1.6e-11 Body mass index; LUSC cis rs240764 0.567 rs12528607 chr6:101260131 A/G cg09795085 chr6:101329169 ASCC3 0.44 6.23 0.32 1.41e-9 Neuroticism; LUSC cis rs75804782 0.641 rs77448526 chr2:239353487 A/C cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs4930561 0.714 rs7950452 chr11:67962407 C/A cg16338278 chr11:67432957 ALDH3B2 0.4 6.73 0.35 7.35e-11 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs1801251 0.896 rs2197563 chr2:233687080 G/A cg25237894 chr2:233734115 C2orf82 -0.33 -6.04 -0.31 4.03e-9 Coronary artery disease; LUSC cis rs13217239 0.646 rs2142685 chr6:27054497 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.31 -6.07 -0.31 3.57e-9 Schizophrenia; LUSC cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg25345767 chr1:226070210 TMEM63A 0.4 6.08 0.32 3.23e-9 Schizophrenia (age at onset); LUSC cis rs9463078 0.764 rs10948190 chr6:44942300 C/T cg25276700 chr6:44698697 NA -0.29 -5.98 -0.31 5.83e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs921665 0.831 rs6836 chr2:3192798 A/G cg16434511 chr2:3151078 NA -0.55 -5.99 -0.31 5.45e-9 World class endurance athleticism; LUSC cis rs56346965 0.967 rs2159819 chr2:191532737 C/G cg11845111 chr2:191398756 TMEM194B -0.43 -6.37 -0.33 6.23e-10 Bone mineral density (Ward's triangle area); LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg05368731 chr17:41323189 NBR1 0.93 15.66 0.65 7.69e-42 Menopause (age at onset); LUSC cis rs9818941 0.824 rs2686541 chr3:157788184 G/C cg08654915 chr3:157813417 NA -0.31 -7.33 -0.37 1.79e-12 Height; LUSC cis rs34779708 0.931 rs59418206 chr10:35331624 G/A cg04310649 chr10:35416472 CREM -0.43 -6.49 -0.33 3.03e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs629535 0.862 rs655028 chr8:70049047 T/C cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg25019033 chr10:957182 NA -0.52 -6.59 -0.34 1.67e-10 Eosinophil percentage of granulocytes; LUSC cis rs977987 0.750 rs4888406 chr16:75432334 G/T cg04384234 chr16:75411784 CFDP1 -0.44 -7.2 -0.37 4.08e-12 Dupuytren's disease; LUSC cis rs412000 0.507 rs2680688 chr17:56450524 T/C cg25039879 chr17:56429692 SUPT4H1 -0.4 -6.1 -0.32 2.88e-9 Primary tooth development (time to first tooth eruption); LUSC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg03709012 chr19:19516395 GATAD2A 0.83 13.76 0.6 1.91e-34 Tonsillectomy; LUSC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC trans rs6601327 0.540 rs12542912 chr8:9585196 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.47 -0.33 3.46e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9506514 0.722 rs11147813 chr13:21258558 T/C cg04906043 chr13:21280425 IL17D -0.31 -5.8 -0.3 1.52e-8 Coronary artery calcification; LUSC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg04450456 chr4:17643702 FAM184B 0.38 6.4 0.33 5.26e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg21665744 chr7:39171113 POU6F2 0.42 6.63 0.34 1.37e-10 IgG glycosylation; LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 14.09 0.61 1.09e-35 Platelet count; LUSC cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.34 5.7 0.3 2.63e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg08798685 chr6:27730294 NA -0.69 -6.14 -0.32 2.4e-9 Depression; LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg04025307 chr7:1156635 C7orf50 0.55 8.73 0.43 1.24e-16 Longevity;Endometriosis; LUSC trans rs2243480 1.000 rs73142166 chr7:65375832 A/G cg10756647 chr7:56101905 PSPH 0.88 8.43 0.42 1.02e-15 Diabetic kidney disease; LUSC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs9875589 0.509 rs6768383 chr3:14076952 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.25 0.37 2.83e-12 Ovarian reserve; LUSC cis rs2580764 0.566 rs2920900 chr2:55280083 T/C cg20993754 chr2:55226987 RTN4 -0.36 -5.91 -0.31 8.45e-9 Mean platelet volume; LUSC cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg12011299 chr4:100065546 ADH4 -0.7 -10.7 -0.51 3.54e-23 Alcohol dependence; LUSC cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.25 0.59 1.67e-32 Chronic sinus infection; LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg00814883 chr7:100076585 TSC22D4 -0.67 -8.7 -0.43 1.58e-16 Platelet count; LUSC trans rs1325195 0.920 rs4651013 chr1:179072966 C/T cg11624085 chr17:8464688 MYH10 -0.42 -6.93 -0.35 2.2e-11 IgE grass sensitization; LUSC cis rs859767 0.741 rs7571113 chr2:135427392 A/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.04 -0.31 4.1e-9 Neuroticism; LUSC cis rs6835098 0.961 rs11737748 chr4:174130503 T/C cg27433088 chr4:174089019 GALNT7 -0.39 -5.72 -0.3 2.37e-8 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs6998277 0.830 rs17186961 chr8:103630028 G/A cg10187029 chr8:103597600 NA 0.76 10.59 0.5 9.03e-23 Migraine; LUSC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg01579765 chr21:45077557 HSF2BP -0.53 -11.3 -0.53 2.78e-25 Mean corpuscular volume; LUSC cis rs17818399 0.890 rs34544165 chr2:46836906 A/G cg02822958 chr2:46747628 ATP6V1E2 0.42 6.7 0.34 8.87e-11 Height; LUSC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.02 15.68 0.65 6.58e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg12165864 chr7:66369176 NA -0.53 -7.15 -0.36 5.51e-12 Corneal structure; LUSC cis rs7177699 0.557 rs62011002 chr15:79120578 C/T cg15571903 chr15:79123663 NA 0.32 5.91 0.31 8.39e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg00431813 chr7:1051703 C7orf50 -0.48 -7.82 -0.39 6.98e-14 Longevity;Endometriosis; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg13464717 chr19:2269532 OAZ1 0.64 6.14 0.32 2.3e-9 Body mass index; LUSC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg04944784 chr2:26401820 FAM59B 0.72 9.98 0.48 1.1e-20 Gut microbiome composition (summer); LUSC cis rs8072100 0.539 rs36043200 chr17:45629406 G/A cg08085267 chr17:45401833 C17orf57 0.61 10.05 0.48 6e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6599222 0.500 rs4130467 chr3:38611704 C/T cg26255052 chr1:23038321 EPHB2 -0.4 -6.22 -0.32 1.47e-9 PR interval; LUSC cis rs7681440 0.874 rs1372524 chr4:90776045 A/G cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.31 1.15e-8 Dementia with Lewy bodies; LUSC cis rs6754311 0.731 rs7569057 chr2:136583958 A/C cg07169764 chr2:136633963 MCM6 0.61 7.94 0.4 3.08e-14 Mosquito bite size; LUSC cis rs250677 0.917 rs36066 chr5:148419771 A/G cg18129178 chr5:148520854 ABLIM3 -0.77 -11.97 -0.55 1e-27 Breast cancer; LUSC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4786125 0.542 rs2345826 chr16:6916235 G/T cg03623568 chr16:6915990 A2BP1 -0.43 -7.39 -0.37 1.22e-12 Heart rate variability traits (SDNN); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13653482 chr9:103361209 NA -0.41 -5.95 -0.31 6.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg07701084 chr6:150067640 NUP43 0.57 8.83 0.44 5.96e-17 Lung cancer; LUSC cis rs6121246 0.909 rs6119651 chr20:30259246 G/T cg13852791 chr20:30311386 BCL2L1 0.83 11.23 0.52 4.97e-25 Mean corpuscular hemoglobin; LUSC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg21132104 chr15:45694354 SPATA5L1 -0.54 -7.76 -0.39 1.04e-13 Homoarginine levels; LUSC cis rs7927592 0.871 rs12360903 chr11:68236314 C/A cg20283391 chr11:68216788 NA -0.61 -8.51 -0.42 5.91e-16 Total body bone mineral density; LUSC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.39 -5.72 -0.3 2.4e-8 Schizophrenia; LUSC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg20295408 chr7:1910781 MAD1L1 -0.46 -6.53 -0.34 2.45e-10 Schizophrenia; LUSC cis rs3768617 1.000 rs12026314 chr1:183104527 A/G ch.1.3577855R chr1:183094577 LAMC1 0.62 9.26 0.45 2.63e-18 Fuchs's corneal dystrophy; LUSC cis rs7903847 0.642 rs61863819 chr10:99142400 T/C cg08345082 chr10:99160200 RRP12 -0.38 -7.45 -0.38 7.85e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs61931739 0.746 rs1687003 chr12:34170099 T/A cg06521331 chr12:34319734 NA -0.35 -6.01 -0.31 4.82e-9 Morning vs. evening chronotype; LUSC trans rs6502050 0.871 rs9916649 chr17:80075739 G/A cg07393940 chr7:158741817 NA -0.37 -6.54 -0.34 2.29e-10 Life satisfaction; LUSC cis rs921665 0.831 rs4402798 chr2:3190969 G/A cg16434511 chr2:3151078 NA -0.61 -6.84 -0.35 3.73e-11 World class endurance athleticism; LUSC cis rs748404 0.631 rs12905772 chr15:43648444 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.29 0.33 1.01e-9 Lung cancer; LUSC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.7 -10.46 -0.5 2.45e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.46 -6.89 -0.35 2.77e-11 Alzheimer's disease (late onset); LUSC cis rs11190604 1.000 rs2495734 chr10:102338686 G/A cg16342193 chr10:102329863 NA -0.38 -6.94 -0.35 2.06e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs27434 0.583 rs151954 chr5:96157689 A/G cg16492584 chr5:96139282 ERAP1 -0.56 -7.53 -0.38 4.91e-13 Ankylosing spondylitis; LUSC cis rs4474465 0.541 rs10736814 chr11:78286462 C/G cg27205649 chr11:78285834 NARS2 0.58 7.01 0.36 1.33e-11 Alzheimer's disease (survival time); LUSC cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg21573476 chr21:45109991 RRP1B -0.4 -6.28 -0.33 1.05e-9 Mean corpuscular volume; LUSC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg06238570 chr21:40685208 BRWD1 0.48 7.54 0.38 4.41e-13 Cognitive function; LUSC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg00825309 chr19:58991885 ZNF446 -0.5 -7.16 -0.36 5.09e-12 Uric acid clearance; LUSC cis rs116988415 0.539 rs11623956 chr14:65270391 G/A cg25083366 chr14:65239357 SPTB 0.66 6.99 0.36 1.46e-11 Daytime sleep phenotypes; LUSC cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg15556689 chr8:8085844 FLJ10661 -0.57 -8.41 -0.42 1.25e-15 Neuroticism; LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg00071950 chr4:10020882 SLC2A9 -0.49 -8.13 -0.41 8.42e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1790761 0.667 rs591434 chr11:67337814 C/T cg24690094 chr11:67383802 NA 0.44 8.5 0.42 6.36e-16 Mean corpuscular volume; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.48e-17 Prudent dietary pattern; LUSC cis rs9512730 0.527 rs11619784 chr13:27999643 A/G cg04070771 chr13:27998621 GTF3A 0.49 6.43 0.33 4.46e-10 Schizophrenia; LUSC cis rs7617773 0.780 rs13090538 chr3:48370769 A/C cg11946769 chr3:48343235 NME6 0.84 13.47 0.59 2.56e-33 Coronary artery disease; LUSC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19782173 chr5:76383047 LOC728723;ZBED3 -0.41 -6.03 -0.31 4.4e-9 Electrocardiographic conduction measures; LUSC trans rs7829975 0.714 rs59046059 chr8:8670736 C/A cg27411982 chr8:10470053 RP1L1 0.44 6.98 0.36 1.59e-11 Mood instability; LUSC cis rs4474465 1.000 rs952605 chr11:78200427 A/T cg27205649 chr11:78285834 NARS2 -0.51 -5.91 -0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs225245 0.791 rs2285742 chr17:34018682 C/T cg05299278 chr17:33885742 SLFN14 0.29 6.31 0.33 8.76e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg15423357 chr2:25149977 NA 0.45 9.09 0.45 8.9e-18 Body mass index; LUSC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.56e-24 Aortic root size; LUSC cis rs9788682 0.948 rs905739 chr15:78845110 A/G cg06917634 chr15:78832804 PSMA4 -0.58 -6.98 -0.36 1.64e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.68 -12.04 -0.55 5.88e-28 Personality dimensions; LUSC cis rs2467099 1.000 rs2467099 chr17:73949045 C/T cg19302996 chr17:73780495 UNK -0.51 -5.93 -0.31 7.62e-9 Systolic blood pressure; LUSC cis rs10876993 0.821 rs1629032 chr12:58038686 C/T cg15848620 chr12:58087721 OS9 -0.53 -7.55 -0.38 4.14e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg12432903 chr7:1882776 MAD1L1 -0.5 -8.5 -0.42 6.44e-16 Bipolar disorder and schizophrenia; LUSC cis rs6964587 1.000 rs35653487 chr7:91745441 C/G cg22117172 chr7:91764530 CYP51A1 0.33 5.83 0.3 1.34e-8 Breast cancer; LUSC cis rs7223966 1.000 rs7223412 chr17:61808172 T/C cg00945038 chr17:61921165 SMARCD2 0.4 6.09 0.32 3.17e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs694739 0.892 rs647152 chr11:64109118 T/G cg23796481 chr11:64053134 BAD;GPR137 0.6 9.73 0.47 7.5e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg15369054 chr17:80825471 TBCD 0.36 6.01 0.31 4.92e-9 Breast cancer; LUSC cis rs10992471 0.603 rs10114932 chr9:95307901 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.88 -0.35 2.92e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs838147 0.537 rs503279 chr19:49209010 C/T cg21064579 chr19:49206444 FUT2 -0.42 -7.99 -0.4 2.23e-14 Dietary macronutrient intake; LUSC cis rs1867631 0.585 rs11208940 chr1:67127242 A/G cg02459107 chr1:67143332 SGIP1 -0.33 -5.74 -0.3 2.1e-8 Menopause (age at onset); LUSC cis rs4148883 0.504 rs4585310 chr4:100120233 T/C cg12011299 chr4:100065546 ADH4 -0.41 -6.65 -0.34 1.19e-10 Alcohol dependence; LUSC cis rs6960043 0.738 rs2358159 chr7:15054908 T/C cg19272540 chr7:15055459 NA 0.35 9.03 0.44 1.39e-17 Type 2 diabetes; LUSC cis rs377070 0.816 rs309400 chr4:123616189 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.4 5.67 0.3 3.06e-8 Mosquito bite size; LUSC cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg01579765 chr21:45077557 HSF2BP -0.52 -10.84 -0.51 1.13e-23 Mean corpuscular volume; LUSC cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg05283184 chr6:79620031 NA -0.55 -10.99 -0.52 3.35e-24 Intelligence (multi-trait analysis); LUSC cis rs10761482 0.683 rs4488150 chr10:62104918 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg11644478 chr21:40555479 PSMG1 0.93 17.84 0.7 1.72e-50 Cognitive function; LUSC trans rs1728785 1.000 rs1170443 chr16:68573295 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.51 0.38 5.28e-13 Ulcerative colitis; LUSC cis rs734999 0.566 rs6664969 chr1:2534978 G/A cg18854424 chr1:2615690 NA 0.51 10.16 0.49 2.58e-21 Ulcerative colitis; LUSC cis rs708547 0.647 rs12621 chr4:57897570 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.52 7.56 0.38 3.92e-13 Response to bleomycin (chromatid breaks); LUSC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.13e-16 Schizophrenia; LUSC cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.75 7.49 0.38 6.31e-13 Initial pursuit acceleration; LUSC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.26 0.64 2.87e-40 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs17685 0.712 rs6464994 chr7:75784668 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.54 -8.23 -0.41 4.13e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs73198271 0.773 rs66618176 chr8:8646974 G/C cg01851573 chr8:8652454 MFHAS1 0.54 8.73 0.43 1.23e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -8.16 -0.41 6.89e-15 Schizophrenia; LUSC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg17211192 chr8:82754475 SNX16 -0.81 -11.02 -0.52 2.72e-24 Diastolic blood pressure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04203429 chr16:29822912 PRRT2 0.45 6.67 0.34 1.08e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7618501 0.633 rs2624843 chr3:49997963 G/A cg21659725 chr3:3221576 CRBN 0.62 10.31 0.49 8.16e-22 Intelligence (multi-trait analysis); LUSC cis rs12367572 0.623 rs10880718 chr12:45362806 G/C cg04608330 chr12:45269318 NELL2 -0.4 -6.14 -0.32 2.41e-9 Gut microbiome composition (summer); LUSC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.99 0.31 5.3e-9 Lung cancer; LUSC cis rs3812762 0.879 rs3763920 chr11:8808587 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -6.89 -0.35 2.86e-11 Hypospadias; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg03934478 chr11:495069 RNH1 0.84 10.03 0.48 7.31e-21 Body mass index; LUSC cis rs4631830 0.832 rs2843554 chr10:51523861 G/T cg20129853 chr10:51489980 NA -0.33 -6.77 -0.35 5.84e-11 Prostate-specific antigen levels; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg02475777 chr4:1388615 CRIPAK 0.44 6.82 0.35 4.34e-11 Obesity-related traits; LUSC cis rs713477 0.935 rs7147968 chr14:55909040 G/A cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -6.14 -0.32 2.31e-9 Life satisfaction; LUSC cis rs473651 0.901 rs563282 chr2:239329736 T/C cg21699342 chr2:239360505 ASB1 0.51 8.9 0.44 3.6e-17 Multiple system atrophy; LUSC cis rs9810089 0.967 rs10935177 chr3:135851077 G/T cg12473912 chr3:136751656 NA -0.32 -5.65 -0.3 3.48e-8 Gestational age at birth (child effect); LUSC cis rs7760949 0.963 rs9396248 chr6:13906360 A/G cg27413430 chr6:13925136 RNF182 0.52 7.85 0.39 5.84e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs6987853 0.966 rs2974359 chr8:42434194 T/C cg09913449 chr8:42400586 C8orf40 0.49 8.29 0.41 2.9e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg03885332 chr11:832357 CD151 -0.35 -5.93 -0.31 7.55e-9 Mean platelet volume; LUSC cis rs757081 0.667 rs12577388 chr11:17101155 C/T cg15432903 chr11:17409602 KCNJ11 -0.39 -6.04 -0.31 4e-9 Systolic blood pressure; LUSC cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg13535736 chr9:111863775 C9orf5 0.37 6.25 0.32 1.26e-9 Menarche (age at onset); LUSC cis rs17030434 0.906 rs12641631 chr4:154665279 A/G cg14289246 chr4:154710475 SFRP2 -0.61 -8.17 -0.41 6.3e-15 Electrocardiographic conduction measures; LUSC cis rs7937682 0.889 rs7948236 chr11:111499933 C/A cg09085632 chr11:111637200 PPP2R1B -1.09 -17.31 -0.69 2.28e-48 Primary sclerosing cholangitis; LUSC cis rs9515201 0.740 rs9555695 chr13:111033125 C/T cg05272587 chr13:111038400 COL4A2 -0.38 -6.11 -0.32 2.7e-9 White matter hyperintensity burden; LUSC cis rs9929218 0.529 rs2296404 chr16:68729525 C/T cg01251360 chr16:68772225 CDH1 -0.27 -6.23 -0.32 1.43e-9 Colorectal cancer; LUSC cis rs3125734 0.572 rs3864794 chr10:64041956 A/C cg19640130 chr10:64028056 RTKN2 -0.4 -6.93 -0.35 2.24e-11 Rheumatoid arthritis; LUSC cis rs1595825 0.891 rs73058867 chr2:198891568 A/G cg00982548 chr2:198649783 BOLL -0.54 -6.93 -0.35 2.2e-11 Ulcerative colitis; LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg04017836 chr7:65315216 NA 0.39 5.98 0.31 5.59e-9 Coronary artery disease; LUSC cis rs3812762 0.957 rs7120004 chr11:8769097 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.38 6.56 0.34 2.06e-10 Hypospadias; LUSC cis rs4285028 0.747 rs7648340 chr3:121426188 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.97 -0.58 1.9e-31 Multiple sclerosis; LUSC cis rs16854884 0.632 rs4446205 chr3:143682607 A/G cg06585982 chr3:143692056 C3orf58 0.45 6.7 0.34 8.62e-11 Economic and political preferences (feminism/equality); LUSC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg08975724 chr8:8085496 FLJ10661 0.53 8.24 0.41 3.97e-15 Mood instability; LUSC cis rs11583043 0.831 rs6667818 chr1:101412313 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.89 0.35 2.76e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs2319125 0.866 rs229859 chr17:64121580 A/T cg18807011 chr1:184633572 NA 0.33 6.13 0.32 2.53e-9 &beta2-Glycoprotein I (β2-GPI) plasma levels; LUSC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg13319975 chr6:146136371 FBXO30 0.71 11.11 0.52 1.24e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg06552810 chr11:31128660 NA -0.4 -7.13 -0.36 6.38e-12 Red blood cell count; LUSC cis rs7647973 1.000 rs11720542 chr3:49357427 A/G cg07636037 chr3:49044803 WDR6 0.66 8.82 0.43 6.69e-17 Menarche (age at onset); LUSC trans rs11098499 0.775 rs10021601 chr4:120282563 G/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg08859206 chr1:53392774 SCP2 -0.54 -9.26 -0.45 2.46e-18 Monocyte count; LUSC cis rs6076065 0.723 rs6083104 chr20:23366038 C/T cg11657817 chr20:23433608 CST11 0.42 8.03 0.4 1.64e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg06784218 chr1:46089804 CCDC17 0.57 11.63 0.54 1.79e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs68170813 0.559 rs17349904 chr7:106897237 A/C cg02696742 chr7:106810147 HBP1 -0.62 -9.36 -0.46 1.25e-18 Coronary artery disease; LUSC cis rs35146811 0.735 rs1727130 chr7:99811464 C/G cg19116668 chr7:99932089 PMS2L1 0.35 6.12 0.32 2.68e-9 Coronary artery disease; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.39 -0.42 1.36e-15 Lymphocyte counts; LUSC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg22875332 chr1:76189707 ACADM 0.85 13.88 0.6 6.66e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12122100 0.651 rs12126527 chr1:146551259 C/G cg03526459 chr1:146549940 NA -0.41 -6.62 -0.34 1.47e-10 HIV-1 control; LUSC trans rs11098499 0.863 rs3822190 chr4:120428098 G/A cg25214090 chr10:38739885 LOC399744 0.52 7.59 0.38 3.33e-13 Corneal astigmatism; LUSC trans rs2039659 0.752 rs1764954 chr13:86253251 G/A cg22803222 chr6:76636725 IMPG1 0.37 5.99 0.31 5.56e-9 Blood osmolality (transformed sodium); LUSC cis rs10197940 0.624 rs13393122 chr2:152413315 A/G cg19508488 chr2:152266495 RIF1 0.54 7.74 0.39 1.17e-13 Lung cancer; LUSC cis rs7408868 0.706 rs7257550 chr19:15292088 C/G cg14696996 chr19:15285081 NOTCH3 0.77 7.82 0.39 7.05e-14 Pulse pressure; LUSC cis rs926938 0.527 rs360580 chr1:115462334 A/G cg12756093 chr1:115239321 AMPD1 0.46 7.0 0.36 1.43e-11 Autism; LUSC cis rs9814567 1.000 rs4955555 chr3:134286427 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.05 -0.61 1.51e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14830952 chr8:86089500 E2F5 0.45 6.7 0.34 8.72e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs870825 0.929 rs10003354 chr4:185589782 G/A cg04058563 chr4:185651563 MLF1IP 0.82 10.86 0.51 1.02e-23 Blood protein levels; LUSC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg11861562 chr11:117069780 TAGLN 0.43 8.06 0.4 1.37e-14 Blood protein levels; LUSC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg26587870 chr6:27730563 NA -0.64 -5.87 -0.31 1.05e-8 Depression; LUSC cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg06462663 chr19:18546047 ISYNA1 0.49 8.24 0.41 3.89e-15 Breast cancer; LUSC cis rs17102423 0.654 rs8015921 chr14:65523015 G/A cg11161011 chr14:65562177 MAX -0.58 -8.87 -0.44 4.37e-17 Obesity-related traits; LUSC cis rs6977660 1.000 rs714239 chr7:19803944 C/T cg07541023 chr7:19748670 TWISTNB 0.53 6.14 0.32 2.37e-9 Thyroid stimulating hormone; LUSC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11644478 chr21:40555479 PSMG1 0.95 19.4 0.73 1.07e-56 Cognitive function; LUSC cis rs7312933 0.558 rs1796381 chr12:42842475 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.65 0.34 1.2e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7712401 0.715 rs424247 chr5:122347993 G/A cg19077854 chr5:122220652 SNX24 -0.41 -8.85 -0.44 5.29e-17 Mean platelet volume; LUSC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs3924048 0.559 rs4075303 chr1:12626593 C/G cg00291366 chr1:12616550 NA 0.32 7.39 0.38 1.16e-12 Optic cup area; LUSC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs734999 0.588 rs867435 chr1:2523706 C/T cg18932078 chr1:2524107 MMEL1 0.34 7.34 0.37 1.63e-12 Ulcerative colitis; LUSC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg04398451 chr17:18023971 MYO15A 0.47 7.31 0.37 2e-12 Total body bone mineral density; LUSC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 12.15 0.55 2.25e-28 Chronic sinus infection; LUSC cis rs983392 0.709 rs2162254 chr11:60039917 T/A cg24026212 chr11:59952134 MS4A6A 0.37 6.38 0.33 5.77e-10 Alzheimer's disease (late onset); LUSC cis rs16976116 0.901 rs28589384 chr15:55494366 A/G cg11288833 chr15:55489084 RSL24D1 0.49 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4343996 0.521 rs10237577 chr7:3424305 C/A cg21248987 chr7:3385318 SDK1 0.37 6.3 0.33 9.65e-10 Motion sickness; LUSC cis rs4595586 0.679 rs1878228 chr12:39355595 T/C cg26384229 chr12:38710491 ALG10B 0.43 5.97 0.31 6.11e-9 Morning vs. evening chronotype; LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.46 -0.33 3.66e-10 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg12463550 chr7:65579703 CRCP 0.41 5.85 0.31 1.15e-8 Aortic root size; LUSC cis rs116139393 0.505 rs3801033 chr7:6734103 A/G cg09896999 chr7:6746977 ZNF12 0.53 8.76 0.43 9.83e-17 Alzheimer's disease (APOE e4 interaction); LUSC cis rs7267979 0.966 rs2145126 chr20:25263648 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.49 0.75 5.16e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2486288 0.656 rs11632920 chr15:45551264 C/T cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.82 -0.51 1.35e-23 Glomerular filtration rate; LUSC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg04518342 chr5:131593106 PDLIM4 0.32 5.72 0.3 2.33e-8 Breast cancer;Mosquito bite size; LUSC cis rs5769707 0.967 rs9616713 chr22:50049109 G/A cg08680598 chr22:49984980 NA -0.35 -6.43 -0.33 4.37e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1572438 0.811 rs6916781 chr6:880493 G/A cg13447295 chr6:887704 NA 0.41 6.45 0.33 3.98e-10 Aging; LUSC cis rs259282 0.538 rs6510272 chr19:33117842 C/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.73 10.46 0.5 2.52e-22 Schizophrenia; LUSC trans rs72674100 1.000 rs7694339 chr4:97968342 C/T cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg01283332 chr5:1856932 NA -0.33 -6.29 -0.33 1e-9 Cardiovascular disease risk factors; LUSC cis rs9300255 0.602 rs1790095 chr12:123681222 G/A cg13010344 chr12:123464640 ARL6IP4 -0.47 -6.38 -0.33 6.03e-10 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4417855 0.665 rs955305 chr3:187409112 A/C cg19198148 chr3:187451818 BCL6 0.55 9.71 0.47 8.32e-20 Granulocyte percentage of myeloid white cells; LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg09301410 chr7:157951964 PTPRN2 0.47 8.59 0.43 3.26e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12618769 0.597 rs3769716 chr2:99133305 G/A cg10123293 chr2:99228465 UNC50 0.46 7.67 0.39 1.95e-13 Bipolar disorder; LUSC trans rs7944735 0.507 rs7934659 chr11:48066374 C/T cg03929089 chr4:120376271 NA 0.59 7.0 0.36 1.42e-11 Intraocular pressure; LUSC cis rs4819052 0.788 rs2236449 chr21:46702506 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.59 8.96 0.44 2.29e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12618769 0.652 rs72823788 chr2:99213080 C/T cg10123293 chr2:99228465 UNC50 0.47 7.7 0.39 1.59e-13 Bipolar disorder; LUSC cis rs9902453 0.817 rs1038089 chr17:28178724 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.69 0.47 9.71e-20 Coffee consumption (cups per day); LUSC cis rs2019216 0.564 rs1518053 chr17:21924272 G/T cg22648282 chr17:21454238 C17orf51 -0.49 -7.28 -0.37 2.48e-12 Pelvic organ prolapse; LUSC cis rs10979 0.597 rs9403514 chr6:143907790 T/C cg25407410 chr6:143891975 LOC285740 -0.65 -8.19 -0.41 5.6e-15 Hypospadias; LUSC cis rs2795502 0.564 rs11239840 chr10:43439353 C/T cg08461752 chr10:43522343 NA -0.55 -6.45 -0.33 3.85e-10 Blood protein levels; LUSC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.65e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg19230755 chr7:65878503 NA -0.42 -5.97 -0.31 5.91e-9 Aortic root size; LUSC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg05729581 chr11:3078854 CARS -0.54 -8.12 -0.41 8.88e-15 Longevity; LUSC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg22535103 chr8:58192502 C8orf71 -0.6 -6.81 -0.35 4.55e-11 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs9358887 chr6:25759406 G/T cg17691542 chr6:26056736 HIST1H1C 0.53 7.32 0.37 1.83e-12 Iron status biomarkers; LUSC cis rs7582180 0.627 rs6749018 chr2:101001859 G/T cg12002119 chr2:101014098 CHST10 0.37 6.29 0.33 1.02e-9 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.512 rs9383905 chr6:151804296 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.56 5.78 0.3 1.73e-8 Menarche (age at onset); LUSC cis rs240764 0.658 rs10872634 chr6:101199579 C/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.09 -0.32 3.04e-9 Neuroticism; LUSC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg02117656 chr17:79614917 TSPAN10 0.32 5.86 0.31 1.12e-8 Eye color traits; LUSC cis rs7666738 0.546 rs13141117 chr4:98892798 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.35 0.46 1.3e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs7188861 0.681 rs12922090 chr16:11415117 C/T cg00044050 chr16:11439710 C16orf75 0.62 6.41 0.33 4.9e-10 HDL cholesterol; LUSC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg02773041 chr1:40204384 PPIE -0.53 -8.13 -0.41 8.59e-15 Blood protein levels; LUSC cis rs6430585 0.583 rs4988201 chr2:136618507 A/G cg07169764 chr2:136633963 MCM6 1.23 19.55 0.73 2.84e-57 Corneal structure; LUSC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg23711669 chr6:146136114 FBXO30 0.77 12.61 0.57 4.46e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg24531977 chr5:56204891 C5orf35 -0.98 -14.68 -0.63 5.64e-38 Initial pursuit acceleration; LUSC cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg00898013 chr13:113819073 PROZ -0.56 -8.08 -0.4 1.21e-14 Platelet distribution width; LUSC cis rs10493773 0.775 rs11161649 chr1:86165446 A/C cg17807903 chr1:86174739 ZNHIT6 -0.49 -11.79 -0.54 4.81e-27 Urate levels in overweight individuals; LUSC cis rs6736093 0.966 rs13033393 chr2:112697632 C/G cg12686935 chr2:112915763 FBLN7 -0.37 -5.9 -0.31 8.73e-9 Coronary artery disease; LUSC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg18876405 chr7:65276391 NA -0.55 -8.66 -0.43 2.09e-16 Aortic root size; LUSC cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg23711669 chr6:146136114 FBXO30 0.87 16.13 0.66 1.08e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs3087591 0.683 rs2040792 chr17:29628549 G/T cg24425628 chr17:29625626 OMG;NF1 0.46 6.9 0.35 2.69e-11 Hip circumference; LUSC trans rs7826238 0.564 rs2921053 chr8:8319963 G/C cg21775007 chr8:11205619 TDH 0.44 6.35 0.33 6.92e-10 Systolic blood pressure; LUSC cis rs8077889 0.672 rs1234612 chr17:41840802 A/G cg26893861 chr17:41843967 DUSP3 1.1 24.61 0.8 5.03e-77 Triglycerides; LUSC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg06134567 chr22:46658398 PKDREJ -0.53 -5.93 -0.31 7.54e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.1 0.36 7.56e-12 Colorectal cancer; LUSC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg09267113 chr7:98030324 BAIAP2L1 0.39 5.86 0.31 1.14e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9467773 0.572 rs2076029 chr6:26390830 T/C cg05738196 chr6:26577821 NA -0.45 -6.41 -0.33 4.95e-10 Intelligence (multi-trait analysis); LUSC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg05855489 chr10:104503620 C10orf26 0.59 9.47 0.46 5.44e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9329221 0.617 rs483916 chr8:9793601 A/C cg27411982 chr8:10470053 RP1L1 -0.44 -7.15 -0.36 5.4e-12 Neuroticism; LUSC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 12.09 0.55 3.69e-28 Personality dimensions; LUSC cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg11057378 chr10:81107060 PPIF 0.37 6.26 0.32 1.2e-9 Height; LUSC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg16520312 chr17:43971471 MAPT;LOC100128977 -0.37 -6.4 -0.33 5.39e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7107174 1.000 rs72931690 chr11:78073192 G/A cg02023728 chr11:77925099 USP35 0.49 7.02 0.36 1.24e-11 Testicular germ cell tumor; LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg20295408 chr7:1910781 MAD1L1 -0.41 -5.88 -0.31 1.01e-8 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg17366294 chr4:99064904 C4orf37 0.61 10.91 0.51 6.76e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.967 rs11117116 chr12:86331087 A/T cg00310523 chr12:86230176 RASSF9 0.4 7.18 0.37 4.67e-12 Major depressive disorder; LUSC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg08219700 chr8:58056026 NA 0.66 8.19 0.41 5.63e-15 Developmental language disorder (linguistic errors); LUSC cis rs4474465 0.850 rs10899539 chr11:78243743 T/C cg27205649 chr11:78285834 NARS2 0.48 5.84 0.3 1.24e-8 Alzheimer's disease (survival time); LUSC cis rs2898681 0.519 rs7670068 chr4:53733984 T/G cg00791764 chr4:53727839 RASL11B 0.56 7.74 0.39 1.22e-13 Optic nerve measurement (cup area); LUSC cis rs9811920 0.893 rs6798114 chr3:99892825 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.35 6.49 0.33 3.16e-10 Axial length; LUSC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg26335602 chr6:28129616 ZNF389 -0.4 -5.7 -0.3 2.64e-8 Depression; LUSC cis rs1775715 0.707 rs2778669 chr10:32161541 C/T cg04359828 chr10:32216031 ARHGAP12 0.4 6.87 0.35 3.07e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12900413 0.603 rs2118848 chr15:90302503 T/C cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg03146154 chr1:46216737 IPP 0.52 7.66 0.39 2.02e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9837602 1.000 rs4571265 chr3:99705111 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -6.17 -0.32 1.96e-9 Breast cancer; LUSC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg04287289 chr16:89883240 FANCA 0.79 14.13 0.61 7.02e-36 Vitiligo; LUSC trans rs1005277 0.579 rs2504143 chr10:38383706 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.57 -0.46 2.51e-19 Extrinsic epigenetic age acceleration; LUSC cis rs59698941 0.943 rs12513758 chr5:132239939 C/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.31 -0.33 8.76e-10 Apolipoprotein A-IV levels; LUSC cis rs11155671 0.530 rs9322228 chr6:150209309 C/G cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.67e-10 Testicular germ cell tumor; LUSC cis rs2236918 1.000 rs1776133 chr1:242025098 C/T cg17736920 chr1:242011382 EXO1 0.45 7.09 0.36 8.27e-12 Menopause (age at onset); LUSC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.37 5.69 0.3 2.82e-8 Platelet count; LUSC cis rs9467773 0.649 rs2145318 chr6:26496603 T/A cg12292205 chr6:26970375 C6orf41 0.38 5.91 0.31 8.31e-9 Intelligence (multi-trait analysis); LUSC cis rs4604732 0.631 rs11490201 chr1:247626262 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs4144743 1.000 rs11871447 chr17:45331618 C/G cg18085866 chr17:45331354 ITGB3 -0.75 -7.81 -0.39 7.38e-14 Body mass index; LUSC cis rs72960926 0.744 rs72957999 chr6:74973822 T/C cg03266952 chr6:74778945 NA -0.87 -7.19 -0.37 4.34e-12 Metabolite levels (MHPG); LUSC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg17724175 chr1:150552817 MCL1 0.37 6.75 0.35 6.68e-11 Tonsillectomy; LUSC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg13866156 chr1:1669148 SLC35E2 0.49 7.85 0.39 5.78e-14 Body mass index; LUSC cis rs7100689 0.646 rs1934696 chr10:82124966 T/C cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs1387259 0.931 rs1107654 chr12:48681097 T/G cg04545296 chr12:48745243 ZNF641 0.33 6.14 0.32 2.4e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg00745463 chr17:30367425 LRRC37B -0.75 -8.66 -0.43 1.98e-16 Hip circumference adjusted for BMI; LUSC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg26754761 chr2:177040938 NA -0.39 -7.66 -0.39 2.09e-13 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg18876405 chr7:65276391 NA -0.68 -12.26 -0.56 9.02e-29 Cotinine glucuronidation; LUSC cis rs9517320 0.534 rs9554478 chr13:99187792 G/A cg07423050 chr13:99094983 FARP1 -0.55 -10.01 -0.48 8.48e-21 Longevity; LUSC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg06636001 chr8:8085503 FLJ10661 0.55 8.38 0.42 1.48e-15 Neuroticism; LUSC cis rs9467773 0.967 rs1535276 chr6:26520941 T/C cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.11e-18 Intelligence (multi-trait analysis); LUSC cis rs911555 0.662 rs4906322 chr14:103879032 A/G cg12935359 chr14:103987150 CKB 0.66 10.66 0.5 4.99e-23 Intelligence (multi-trait analysis); LUSC cis rs8058578 1.000 rs7187359 chr16:30703155 G/A cg05768032 chr16:30646687 NA 0.4 5.96 0.31 6.32e-9 Multiple myeloma; LUSC cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg24558204 chr6:135376177 HBS1L -0.69 -10.92 -0.51 6.29e-24 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg05084668 chr3:125655381 ALG1L -0.5 -6.98 -0.36 1.58e-11 Blood pressure (smoking interaction); LUSC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg00339695 chr16:24857497 SLC5A11 -0.59 -9.3 -0.45 1.9e-18 Intelligence (multi-trait analysis); LUSC trans rs12478296 0.591 rs6746311 chr2:243001279 A/G cg01596870 chr19:55963115 NA -0.53 -7.32 -0.37 1.9e-12 Obesity-related traits; LUSC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg08975724 chr8:8085496 FLJ10661 -0.48 -7.16 -0.36 5.13e-12 Neuroticism; LUSC cis rs7527798 0.592 rs11118281 chr1:207832102 C/T cg09232269 chr1:207846808 CR1L -0.29 -6.15 -0.32 2.17e-9 Erythrocyte sedimentation rate; LUSC cis rs2404602 0.735 rs2461871 chr15:76822418 C/G cg23625390 chr15:77176239 SCAPER -0.56 -8.47 -0.42 7.81e-16 Blood metabolite levels; LUSC cis rs6964587 1.000 rs10270598 chr7:91700827 T/C cg22709100 chr7:91322751 NA 0.39 5.75 0.3 1.98e-8 Breast cancer; LUSC cis rs67478160 0.634 rs2368559 chr14:104230535 C/T cg08213375 chr14:104286397 PPP1R13B 0.47 9.18 0.45 4.76e-18 Schizophrenia; LUSC cis rs870825 1.000 rs870823 chr4:185588195 G/A cg04058563 chr4:185651563 MLF1IP 0.86 11.24 0.52 4.6e-25 Blood protein levels; LUSC cis rs912057 0.585 rs1745341 chr6:6744990 T/C cg06612196 chr6:6737390 NA 0.56 11.11 0.52 1.31e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs6688613 0.694 rs11576455 chr1:166811970 G/A cg07049167 chr1:166818506 POGK 0.52 7.67 0.39 1.93e-13 Refractive astigmatism; LUSC cis rs2970818 0.831 rs11063193 chr12:4591100 T/C cg11146114 chr12:4671731 NA -0.63 -6.29 -0.33 1e-9 Phosphorus levels; LUSC cis rs3099143 1.000 rs3102710 chr15:77061148 T/C cg21673338 chr15:77095150 SCAPER -0.84 -8.22 -0.41 4.7e-15 Recalcitrant atopic dermatitis; LUSC cis rs9419702 0.538 rs4074772 chr10:133540006 A/T cg04492858 chr10:133558786 NA 0.38 6.05 0.31 3.82e-9 Survival in rectal cancer; LUSC cis rs7927592 0.513 rs556442 chr11:68192690 G/A cg16797656 chr11:68205561 LRP5 -0.42 -7.4 -0.38 1.09e-12 Total body bone mineral density; LUSC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg13535736 chr9:111863775 C9orf5 -0.4 -6.69 -0.34 9.51e-11 Menarche (age at onset); LUSC cis rs7903847 0.620 rs11189165 chr10:99123457 A/G cg20016023 chr10:99160130 RRP12 -0.34 -8.18 -0.41 5.86e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs17270561 0.666 rs9356987 chr6:25739187 C/A cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00298675 chr2:73612788 ALMS1 -0.39 -5.99 -0.31 5.46e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg17178900 chr1:205818956 PM20D1 0.84 14.54 0.62 1.97e-37 Menarche (age at onset); LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg11645453 chr3:52864694 ITIH4 0.31 7.24 0.37 3.16e-12 Electroencephalogram traits; LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg08736216 chr1:53307985 ZYG11A 0.29 6.03 0.31 4.36e-9 Monocyte count; LUSC cis rs3755132 0.929 rs4668458 chr2:15789441 G/A cg12888861 chr2:15731646 DDX1 0.51 7.66 0.39 1.99e-13 Wilms tumor; LUSC trans rs6076960 0.684 rs6054049 chr20:6254909 A/G cg17788362 chr6:86352627 SYNCRIP -0.48 -7.24 -0.37 3.02e-12 Smooth-surface caries; LUSC cis rs826838 0.510 rs10876149 chr12:39228083 C/G cg13010199 chr12:38710504 ALG10B -0.59 -8.66 -0.43 2.05e-16 Heart rate; LUSC cis rs742132 0.527 rs12526321 chr6:25494503 A/G cg12310025 chr6:25882481 NA 0.45 6.16 0.32 2.05e-9 Uric acid levels; LUSC cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs9369695 0.881 rs9349409 chr6:47463126 G/T cg12968598 chr6:47444699 CD2AP 0.53 8.0 0.4 2.1e-14 Reticulocyte count; LUSC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg20891558 chr2:74357851 NA 0.8 14.66 0.63 6.31e-38 Gestational age at birth (maternal effect); LUSC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.35 0.46 1.28e-18 Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05270290 chr15:29562120 NDNL2;FAM189A1 0.47 6.28 0.32 1.08e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.72 0.7 5.41e-50 Chronic sinus infection; LUSC cis rs7223966 1.000 rs7216798 chr17:61740963 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.33 0.37 1.75e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg00814883 chr7:100076585 TSC22D4 -0.66 -8.6 -0.43 3.07e-16 Platelet count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13150040 chr1:204381152 PPP1R15B 0.71 6.14 0.32 2.32e-9 Cognitive performance; LUSC cis rs3540 0.597 rs1978150 chr15:91037041 A/G cg10434728 chr15:90938212 IQGAP1 -0.38 -7.37 -0.37 1.34e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg06112835 chr11:68658793 MRPL21 0.49 7.42 0.38 9.55e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4692589 0.581 rs6821231 chr4:170959988 C/T cg19918862 chr4:170955249 NA 0.36 6.75 0.35 6.47e-11 Anxiety disorder; LUSC cis rs11122272 0.705 rs2572260 chr1:231486189 T/C cg06096015 chr1:231504339 EGLN1 0.55 9.66 0.47 1.23e-19 Hemoglobin concentration; LUSC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg12365402 chr11:9010492 NRIP3 -0.36 -6.05 -0.31 3.95e-9 Hematocrit; LUSC cis rs3931020 0.688 rs455032 chr1:75196488 C/T cg10128416 chr1:75198403 TYW3;CRYZ -0.63 -8.55 -0.42 4.6e-16 Resistin levels; LUSC trans rs11992162 0.613 rs6998690 chr8:11798796 A/T cg06636001 chr8:8085503 FLJ10661 0.45 6.33 0.33 7.77e-10 Monocyte count; LUSC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg21016266 chr12:122356598 WDR66 0.63 9.43 0.46 7.11e-19 Mean corpuscular volume; LUSC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg24733560 chr20:60626293 TAF4 0.36 5.93 0.31 7.49e-9 Body mass index; LUSC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg25282410 chr6:160211355 TCP1;MRPL18 1.12 17.29 0.69 2.67e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg09267113 chr7:98030324 BAIAP2L1 0.38 5.78 0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19895882 chr13:42534974 KIAA0564 -0.43 -6.48 -0.33 3.21e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7264396 0.616 rs6060744 chr20:34581555 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.97 -0.36 1.69e-11 Total cholesterol levels; LUSC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg04871131 chr7:94954202 PON1 -0.38 -6.06 -0.31 3.62e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg12419862 chr22:24373484 LOC391322 -0.58 -7.24 -0.37 3.06e-12 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs4722404 0.800 rs7809262 chr7:3141137 A/G cg19214707 chr7:3157722 NA -0.32 -5.89 -0.31 9.37e-9 Atopic dermatitis; LUSC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg03395651 chr16:88107091 BANP -0.36 -5.68 -0.3 2.97e-8 Menopause (age at onset); LUSC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg08999081 chr20:33150536 PIGU -0.4 -7.49 -0.38 6.16e-13 Glomerular filtration rate (creatinine); LUSC cis rs9650315 0.866 rs34108747 chr8:57197355 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.13 0.36 6.25e-12 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25595571 chr14:104029029 BAG5;C14orf153 -0.56 -7.45 -0.38 8.05e-13 Bipolar disorder and schizophrenia; LUSC cis rs28647808 0.881 rs7040821 chr9:136263584 C/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs3087591 1.000 rs7406983 chr17:29703374 G/A cg24425628 chr17:29625626 OMG;NF1 -0.56 -7.95 -0.4 2.85e-14 Hip circumference; LUSC cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg06784218 chr1:46089804 CCDC17 -0.57 -11.33 -0.53 2.14e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.86 -0.35 3.25e-11 Tonsillectomy; LUSC cis rs1467026 0.691 rs9985266 chr3:12803162 C/T cg05775895 chr3:12838266 CAND2 -0.41 -5.94 -0.31 7.04e-9 P wave duration; LUSC cis rs67460515 0.563 rs11922957 chr3:160828865 A/C cg03342759 chr3:160939853 NMD3 -0.44 -6.11 -0.32 2.7e-9 Parkinson's disease; LUSC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg21770322 chr7:97807741 LMTK2 0.4 7.01 0.36 1.31e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9325144 0.647 rs7316392 chr12:39064381 T/G cg26384229 chr12:38710491 ALG10B -0.62 -9.54 -0.46 3.1400000000000002e-19 Morning vs. evening chronotype; LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg24642844 chr7:1081250 C7orf50 -0.8 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg09658497 chr7:2847517 GNA12 -0.33 -5.74 -0.3 2.18e-8 Height; LUSC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC trans rs6496932 0.913 rs7403354 chr15:85820855 C/T cg26334166 chr20:61950840 COL20A1 0.31 6.11 0.32 2.85e-9 Central corneal thickness;Corneal structure; LUSC cis rs4786125 0.581 rs7193000 chr16:6918270 G/C cg03623568 chr16:6915990 A2BP1 -0.43 -7.5 -0.38 5.74e-13 Heart rate variability traits (SDNN); LUSC cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg09184832 chr6:79620586 NA -0.42 -6.8 -0.35 4.71e-11 Intelligence (multi-trait analysis); LUSC cis rs2386661 0.603 rs11259704 chr10:5646999 C/T cg12223502 chr10:5658492 NA -0.37 -6.03 -0.31 4.34e-9 Breast cancer; LUSC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs67460515 0.531 rs13315565 chr3:160754626 G/C cg03342759 chr3:160939853 NMD3 -0.42 -5.81 -0.3 1.42e-8 Parkinson's disease; LUSC cis rs6138458 1.000 rs227658 chr20:24932028 A/G cg06937882 chr20:24974362 C20orf3 -0.44 -7.57 -0.38 3.67e-13 Blood protein levels; LUSC cis rs9486719 1.000 rs12191653 chr6:96903898 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.81 -0.47 4e-20 Migraine;Coronary artery disease; LUSC cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg15556689 chr8:8085844 FLJ10661 0.63 10.19 0.49 2.03e-21 Mood instability; LUSC cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg16339924 chr4:17578868 LAP3 0.66 10.37 0.49 4.83e-22 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2239815 0.576 rs10427628 chr22:29239766 T/C cg02153584 chr22:29168773 CCDC117 0.58 7.19 0.37 4.3e-12 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs10887741 0.546 rs7903516 chr10:89441102 T/C cg13926569 chr10:89418898 PAPSS2 0.32 6.94 0.36 2.05e-11 Exercise (leisure time); LUSC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg22029157 chr1:209979665 IRF6 0.75 11.18 0.52 7.25e-25 Cleft lip with or without cleft palate; LUSC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg17366294 chr4:99064904 C4orf37 0.58 10.25 0.49 1.25e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 1.000 rs2257988 chr20:25270003 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.46 0.75 6.72e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10186029 0.582 rs12052695 chr2:214003559 G/T cg08319019 chr2:214017104 IKZF2 0.49 7.55 0.38 4.22e-13 Systemic sclerosis; LUSC cis rs10504073 0.584 rs56068225 chr8:49923988 A/G cg00325661 chr8:49890786 NA 0.7 11.11 0.52 1.28e-24 Blood metabolite ratios; LUSC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg03233332 chr7:66118400 NA -0.41 -5.96 -0.31 6.35e-9 Aortic root size; LUSC trans rs61931739 0.591 rs4931764 chr12:33979423 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.61 0.38 2.78e-13 Morning vs. evening chronotype; LUSC trans rs2797160 1.000 rs1954361 chr6:126001423 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.16e-10 Endometrial cancer; LUSC cis rs4363385 0.747 rs11205149 chr1:152958840 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.64 -0.39 2.39e-13 Inflammatory skin disease; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg07157834 chr1:205819609 PM20D1 -0.52 -7.98 -0.4 2.37e-14 Menarche (age at onset); LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs8014204 0.604 rs12147862 chr14:75384471 C/T cg03030879 chr14:75389066 RPS6KL1 0.39 7.46 0.38 7.64e-13 Caffeine consumption; LUSC cis rs7904368 0.754 rs12253908 chr10:16853358 T/C cg14835575 chr10:16859367 RSU1 0.75 9.41 0.46 8.36e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs4343996 0.566 rs55940354 chr7:3431534 C/T cg21248987 chr7:3385318 SDK1 0.36 5.94 0.31 7.33e-9 Motion sickness; LUSC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg07959070 chr22:50026188 C22orf34 -0.36 -7.39 -0.37 1.22e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs500891 0.574 rs13193879 chr6:84123006 T/C cg08257003 chr6:84140564 ME1 0.36 8.81 0.43 7e-17 Platelet-derived growth factor BB levels; LUSC cis rs244293 1.000 rs244295 chr17:53242899 T/A cg19360675 chr17:53046073 COX11;STXBP4 -0.4 -5.78 -0.3 1.68e-8 Menarche (age at onset); LUSC cis rs12908161 1.000 rs12899981 chr15:85302373 G/A cg12863693 chr15:85201151 NMB 0.41 8.48 0.42 7.34e-16 Schizophrenia; LUSC cis rs894734 0.535 rs10783613 chr12:54321966 G/T cg17410650 chr12:54324560 NA -0.56 -10.22 -0.49 1.64e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07763516 chr16:71496321 ZNF23 0.43 6.62 0.34 1.43e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7267979 1.000 rs11087521 chr20:25440648 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.91 0.7 9.06e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.49 -0.33 3.07e-10 Joint mobility (Beighton score); LUSC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs10506458 1.000 rs73127086 chr12:63415626 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -16.23 -0.66 4.58e-44 Hemostatic factors and hematological phenotypes; LUSC cis rs2200578 0.841 rs116668293 chr2:99596991 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.55 6.61 0.34 1.48e-10 IgG glycosylation; LUSC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg09165964 chr15:75287851 SCAMP5 -1.06 -15.86 -0.66 1.22e-42 Blood trace element (Zn levels); LUSC cis rs250677 0.958 rs36078 chr5:148430567 G/A cg18129178 chr5:148520854 ABLIM3 -0.73 -10.91 -0.51 6.51e-24 Breast cancer; LUSC cis rs11098499 0.739 rs6534130 chr4:120131339 A/T cg09307838 chr4:120376055 NA -0.6 -8.77 -0.43 8.98e-17 Corneal astigmatism; LUSC cis rs10905065 0.965 rs10737019 chr10:5783733 G/A cg11519256 chr10:5708881 ASB13 0.4 5.82 0.3 1.35e-8 Menopause (age at onset); LUSC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg14552801 chr7:65878734 NA 0.37 5.74 0.3 2.14e-8 Aortic root size; LUSC cis rs727505 0.866 rs66650870 chr7:124713194 T/C cg23710748 chr7:124431027 NA -0.4 -7.04 -0.36 1.11e-11 Lewy body disease; LUSC cis rs113835537 0.529 rs75003264 chr11:66256099 G/A cg24851651 chr11:66362959 CCS 0.53 7.72 0.39 1.37e-13 Airway imaging phenotypes; LUSC cis rs17125944 0.505 rs74620173 chr14:53194068 G/T cg13660082 chr14:53194042 PSMC6 -0.79 -6.97 -0.36 1.69e-11 Alzheimer's disease (late onset); LUSC cis rs7945705 0.806 rs12224436 chr11:8815825 C/A cg12365402 chr11:9010492 NRIP3 0.48 8.48 0.42 7.46e-16 Hemoglobin concentration; LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg24642844 chr7:1081250 C7orf50 -0.81 -10.9 -0.51 7.43e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg23711669 chr6:146136114 FBXO30 0.84 15.6 0.65 1.39e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs1325195 0.920 rs4651012 chr1:179071865 G/A cg11624085 chr17:8464688 MYH10 -0.42 -6.84 -0.35 3.7e-11 IgE grass sensitization; LUSC cis rs57590327 0.508 rs4622918 chr3:81965382 A/G cg07356753 chr3:81810745 GBE1 -0.58 -8.28 -0.41 3.07e-15 Extraversion; LUSC cis rs1107366 0.593 rs12635766 chr3:125930021 T/C cg01346077 chr3:125931526 NA 0.51 9.83 0.47 3.31e-20 Metabolite levels; LUSC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg12436631 chr1:155007014 DCST1;DCST2 0.45 10.17 0.49 2.37e-21 Schizophrenia; LUSC cis rs2227631 1.000 rs2227631 chr7:100769538 A/G cg08053846 chr7:100769605 SERPINE1 -0.37 -7.77 -0.39 9.82e-14 Plasminogen activator inhibitor type 1 levels (PAI-1); LUSC cis rs9479482 0.935 rs9479507 chr6:150366514 T/G cg00432049 chr6:150390894 ULBP3 -0.29 -6.17 -0.32 1.95e-9 Alopecia areata; LUSC cis rs2797160 1.000 rs1418642 chr6:125999768 G/A cg05901451 chr6:126070800 HEY2 -0.58 -8.67 -0.43 1.88e-16 Endometrial cancer; LUSC cis rs11608355 0.810 rs2217971 chr12:109857666 G/C cg05360138 chr12:110035743 NA 0.6 8.06 0.4 1.34e-14 Neuroticism; LUSC cis rs7772486 0.846 rs2492856 chr6:146323928 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.15 -0.36 5.64e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs600231 0.706 rs10896016 chr11:65335705 C/T cg21890820 chr11:65308645 LTBP3 -0.57 -8.37 -0.42 1.65e-15 Bone mineral density; LUSC cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.41 -0.33 4.9e-10 Monocyte percentage of white cells; LUSC cis rs7590368 0.640 rs56260452 chr2:10954843 C/G cg15705551 chr2:10952987 PDIA6 0.52 5.71 0.3 2.5e-8 Educational attainment (years of education); LUSC cis rs56283067 0.847 rs62435998 chr6:44695206 C/T cg18551225 chr6:44695536 NA -0.48 -8.07 -0.4 1.25e-14 Total body bone mineral density; LUSC cis rs3784262 0.654 rs4646568 chr15:58344290 A/G cg12031962 chr15:58353849 ALDH1A2 0.41 7.67 0.39 1.85e-13 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs10751667 0.961 rs7480178 chr11:927108 T/C ch.11.42038R chr11:967971 AP2A2 0.53 7.83 0.39 6.49e-14 Alzheimer's disease (late onset); LUSC trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg15704280 chr7:45808275 SEPT13 -0.88 -11.66 -0.54 1.34e-26 Coronary artery disease; LUSC cis rs6982240 0.514 rs892362 chr8:142269214 A/G cg27411547 chr8:142287226 NA 0.47 7.93 0.4 3.38e-14 Tonsillectomy; LUSC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg24110177 chr3:50126178 RBM5 0.57 9.36 0.46 1.18e-18 Intelligence (multi-trait analysis); LUSC cis rs6964587 0.900 rs4279 chr7:91764128 C/A cg17063962 chr7:91808500 NA 0.62 9.81 0.47 3.87e-20 Breast cancer; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg15147215 chr3:52552868 STAB1 -0.32 -6.25 -0.32 1.24e-9 Electroencephalogram traits; LUSC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg06740227 chr12:86229804 RASSF9 0.44 7.07 0.36 9.33e-12 Major depressive disorder; LUSC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg01193554 chr1:41846683 NA -0.28 -5.9 -0.31 9.13e-9 Intelligence (multi-trait analysis); LUSC cis rs17490626 0.533 rs12771890 chr10:71189483 T/A cg12610070 chr10:71211762 TSPAN15 -0.5 -9.63 -0.47 1.54e-19 Thrombosis; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg16606324 chr3:10149918 C3orf24 0.62 9.15 0.45 5.73e-18 Alzheimer's disease; LUSC cis rs1113500 0.966 rs11185249 chr1:108611646 C/A cg06207961 chr1:108661230 NA 0.4 7.27 0.37 2.5e-12 Growth-regulated protein alpha levels; LUSC trans rs6502050 0.835 rs66932937 chr17:80116803 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs9788682 0.747 rs2938674 chr15:78757913 C/A cg18825076 chr15:78729989 IREB2 0.44 6.07 0.31 3.56e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1784581 0.631 rs3016544 chr6:162393065 T/C cg17173639 chr6:162384350 PARK2 -0.68 -12.1 -0.55 3.28e-28 Itch intensity from mosquito bite; LUSC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg21238619 chr17:78079768 GAA -0.3 -6.05 -0.31 3.96e-9 Yeast infection; LUSC cis rs7098414 0.530 rs4146515 chr10:82116602 G/A cg00277334 chr10:82204260 NA -0.55 -8.74 -0.43 1.19e-16 Post bronchodilator FEV1; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg05552183 chr6:42928497 GNMT 0.52 8.67 0.43 1.9e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg12516959 chr21:47718080 NA -0.39 -6.3 -0.33 9.61e-10 Testicular germ cell tumor; LUSC cis rs968451 1.000 rs12628705 chr22:39693518 C/G cg17798944 chr22:39715225 SNORD43;RPL3 0.69 9.02 0.44 1.47e-17 Primary biliary cholangitis; LUSC cis rs9650315 0.929 rs7841006 chr8:57172068 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.5 6.58 0.34 1.84e-10 Height; LUSC cis rs35110281 0.626 rs10854486 chr21:45118280 G/T cg01579765 chr21:45077557 HSF2BP -0.55 -11.61 -0.54 2.01e-26 Mean corpuscular volume; LUSC cis rs13006833 0.739 rs291428 chr2:191197226 G/T cg21644426 chr2:191273491 MFSD6 0.45 6.38 0.33 6.07e-10 Urinary metabolites; LUSC cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg22681709 chr2:178499509 PDE11A -0.34 -6.11 -0.32 2.81e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs908922 0.676 rs10888494 chr1:152514709 T/C cg20991723 chr1:152506922 NA 0.51 9.63 0.47 1.55e-19 Hair morphology; LUSC cis rs4332037 0.950 rs11767515 chr7:1941051 C/T cg23422044 chr7:1970798 MAD1L1 -0.65 -7.32 -0.37 1.84e-12 Bipolar disorder; LUSC cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg21466736 chr12:48725269 NA -0.33 -5.8 -0.3 1.53e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg14416269 chr4:6271139 WFS1 0.51 10.73 0.51 2.89e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -14.2 -0.61 4e-36 Chronic sinus infection; LUSC cis rs2303282 0.716 rs7187883 chr16:56445999 C/A cg00500540 chr16:56394104 NA -0.43 -7.35 -0.37 1.57e-12 Breast cancer; LUSC cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg01884057 chr2:25150051 NA 0.49 11.37 0.53 1.49e-25 Body mass index; LUSC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC cis rs763121 0.925 rs4821797 chr22:39016182 T/C cg06022373 chr22:39101656 GTPBP1 0.78 13.17 0.58 3.47e-32 Menopause (age at onset); LUSC trans rs7647973 0.667 rs9869256 chr3:49624095 T/G cg21659725 chr3:3221576 CRBN -0.72 -7.62 -0.38 2.66e-13 Menarche (age at onset); LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.45 6.18 0.32 1.83e-9 Renal function-related traits (BUN); LUSC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg20976159 chr1:228193529 WNT3A 0.28 5.79 0.3 1.64e-8 Diastolic blood pressure; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg20504077 chr8:27472321 CLU -0.43 -6.42 -0.33 4.68e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1267303 0.675 rs1267309 chr1:46987342 G/A cg25110126 chr1:46999211 NA -0.56 -7.54 -0.38 4.58e-13 Monobrow; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg16031515 chr1:205743344 RAB7L1 -0.27 -5.74 -0.3 2.13e-8 Menarche (age at onset); LUSC cis rs12579753 0.917 rs11115032 chr12:82205073 T/C cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg22823121 chr1:150693482 HORMAD1 0.5 7.57 0.38 3.78e-13 Tonsillectomy; LUSC cis rs72634258 0.945 rs2050198 chr1:8111839 T/G cg00042356 chr1:8021962 PARK7 0.78 9.27 0.45 2.37e-18 Inflammatory bowel disease; LUSC cis rs62103177 0.525 rs10438902 chr18:77745640 A/G cg02751453 chr18:77725136 HSBP1L1 0.46 6.3 0.33 9.58e-10 Opioid sensitivity; LUSC cis rs12464559 0.522 rs1916301 chr2:152640498 G/A cg01189475 chr2:152685088 ARL5A 0.61 6.61 0.34 1.5e-10 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs7575217 0.682 rs4851401 chr2:101700518 T/C cg23907051 chr2:101730305 TBC1D8 0.29 7.72 0.39 1.34e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg25319279 chr11:5960081 NA -0.38 -5.79 -0.3 1.65e-8 DNA methylation (variation); LUSC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg25208724 chr1:156163844 SLC25A44 1.1 26.78 0.83 3.78e-85 Testicular germ cell tumor; LUSC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg13683864 chr3:40499215 RPL14 -1.14 -20.56 -0.75 2.88e-61 Renal cell carcinoma; LUSC cis rs12893668 0.703 rs34896432 chr14:104027995 C/T cg04998671 chr14:104000505 TRMT61A -0.47 -6.72 -0.35 7.76e-11 Reticulocyte count; LUSC cis rs7824557 0.713 rs6601575 chr8:11097804 A/C cg21775007 chr8:11205619 TDH 0.46 7.02 0.36 1.21e-11 Retinal vascular caliber; LUSC cis rs977987 0.866 rs12932606 chr16:75493944 C/T cg03315344 chr16:75512273 CHST6 0.53 9.98 0.48 1.07e-20 Dupuytren's disease; LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03352830 chr11:487213 PTDSS2 0.7 8.47 0.42 8.12e-16 Body mass index; LUSC cis rs11585357 1.000 rs11203346 chr1:17600822 A/G cg08277548 chr1:17600880 PADI3 -0.66 -7.02 -0.36 1.26e-11 Hair shape; LUSC cis rs6594499 0.872 rs10045255 chr5:110438357 C/T cg04022379 chr5:110408740 TSLP -0.42 -6.56 -0.34 2.04e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2742417 1.000 rs2742421 chr3:45732515 G/T cg09608765 chr3:45636137 LIMD1 0.36 6.87 0.35 3.06e-11 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21659725 chr3:3221576 CRBN -0.59 -8.31 -0.41 2.47e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg24642439 chr20:33292090 TP53INP2 0.52 7.86 0.39 5.51e-14 Coronary artery disease; LUSC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg12463550 chr7:65579703 CRCP -0.47 -7.1 -0.36 7.36e-12 Aortic root size; LUSC trans rs17266958 1.000 rs1591017 chr9:83300287 G/A cg01905489 chr1:26616534 UBXN11 -0.58 -6.38 -0.33 6.04e-10 Preschool internalizing problems; LUSC trans rs9291683 0.588 rs12647117 chr4:10022059 T/C cg26043149 chr18:55253948 FECH 0.51 7.47 0.38 7.28e-13 Bone mineral density; LUSC cis rs7312933 0.558 rs11181502 chr12:42823833 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.87 0.35 3.15e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6845621 0.727 rs28799570 chr4:18912156 T/C cg12196642 chr4:18937545 NA -0.34 -6.34 -0.33 7.28e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs11155671 0.530 rs2342767 chr6:150209717 C/G cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.67e-10 Testicular germ cell tumor; LUSC cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.34 -0.42 1.98e-15 Schizophrenia; LUSC cis rs1062746 0.520 rs17698303 chr16:87329543 C/G cg02258303 chr16:87377426 FBXO31 -0.51 -7.75 -0.39 1.15e-13 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg08975724 chr8:8085496 FLJ10661 0.52 7.41 0.38 1.08e-12 Mood instability; LUSC cis rs7826238 0.502 rs10503377 chr8:8378422 C/T cg06636001 chr8:8085503 FLJ10661 0.43 5.65 0.3 3.48e-8 Systolic blood pressure; LUSC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg13319975 chr6:146136371 FBXO30 0.52 7.73 0.39 1.32e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg00339695 chr16:24857497 SLC5A11 -0.62 -9.66 -0.47 1.27e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6500395 0.775 rs7191225 chr16:48662675 C/G cg04672837 chr16:48644449 N4BP1 0.51 7.86 0.39 5.43e-14 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs13082711 0.834 rs2172297 chr3:27428423 C/T cg02860705 chr3:27208620 NA 0.45 7.5 0.38 5.65e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs34734847 0.842 rs7308648 chr12:121144144 C/G cg27246729 chr12:121163418 ACADS 0.42 6.69 0.34 9.4e-11 Mean corpuscular volume; LUSC trans rs4957048 0.577 rs56294732 chr5:568144 T/C cg11887960 chr12:57824829 NA 0.47 6.47 0.33 3.41e-10 Ulcerative colitis; LUSC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg06634786 chr22:41940651 POLR3H -0.46 -5.83 -0.3 1.34e-8 Vitiligo; LUSC cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.56 9.45 0.46 6.08e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6977660 0.619 rs10271639 chr7:19779604 G/A cg07541023 chr7:19748670 TWISTNB 0.6 6.57 0.34 1.95e-10 Thyroid stimulating hormone; LUSC cis rs2274273 0.624 rs8015211 chr14:55841447 A/G cg04306507 chr14:55594613 LGALS3 0.46 9.01 0.44 1.68e-17 Protein biomarker; LUSC cis rs11098499 1.000 rs7659194 chr4:120207147 T/G cg09307838 chr4:120376055 NA 0.7 10.25 0.49 1.24e-21 Corneal astigmatism; LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.59 -0.5 8.72e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs62400317 0.826 rs62400335 chr6:45347782 G/A cg20913747 chr6:44695427 NA -0.48 -7.81 -0.39 7.39e-14 Total body bone mineral density; LUSC cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg16386425 chr10:429943 DIP2C 0.46 7.31 0.37 1.94e-12 Psychosis in Alzheimer's disease; LUSC cis rs2235649 0.663 rs113908028 chr16:1848915 G/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -5.92 -0.31 7.81e-9 Blood metabolite levels; LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg03354898 chr7:1950403 MAD1L1 -0.34 -6.58 -0.34 1.86e-10 Bipolar disorder and schizophrenia; LUSC cis rs5758511 0.773 rs8140869 chr22:42344297 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.4 -6.66 -0.34 1.12e-10 Birth weight; LUSC cis rs11098499 1.000 rs58601355 chr4:120186367 T/C cg09307838 chr4:120376055 NA 0.71 10.08 0.48 4.93e-21 Corneal astigmatism; LUSC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg18479299 chr3:125709523 NA -0.48 -5.85 -0.3 1.18e-8 Blood pressure (smoking interaction); LUSC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.26 -0.37 2.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1335645 0.502 rs618089 chr1:111625277 T/C cg00321911 chr1:111669324 DRAM2 0.51 5.83 0.3 1.32e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504073 0.647 rs10957357 chr8:49988587 C/A cg00325661 chr8:49890786 NA 0.62 10.08 0.48 5.07e-21 Blood metabolite ratios; LUSC cis rs9650657 0.771 rs4840516 chr8:10667335 C/G cg27411982 chr8:10470053 RP1L1 0.36 5.86 0.31 1.09e-8 Neuroticism; LUSC cis rs6736093 0.966 rs11674891 chr2:112713116 A/G cg12686935 chr2:112915763 FBLN7 -0.36 -5.81 -0.3 1.45e-8 Coronary artery disease; LUSC trans rs17685 0.753 rs1859791 chr7:75786043 T/C cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.84 0.3 1.21e-8 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.765 rs2309454 chr2:99595418 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.51e-15 Chronic sinus infection; LUSC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg08975724 chr8:8085496 FLJ10661 0.52 7.75 0.39 1.11e-13 Mood instability; LUSC cis rs1267303 0.642 rs11588450 chr1:47000996 C/T cg25110126 chr1:46999211 NA -0.71 -10.64 -0.5 5.7e-23 Monobrow; LUSC cis rs1124376 1.000 rs73038113 chr3:20139025 T/A cg05072819 chr3:20081367 KAT2B 0.66 7.38 0.37 1.25e-12 Bipolar disorder and schizophrenia; LUSC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg04267008 chr7:1944627 MAD1L1 -0.51 -7.44 -0.38 8.38e-13 Schizophrenia; LUSC cis rs710865 0.519 rs10753518 chr1:19483593 T/C cg13387374 chr1:19411106 UBR4 0.52 8.15 0.41 7.55e-15 Brain structure; LUSC cis rs34779708 0.966 rs12765038 chr10:35416513 G/C cg04310649 chr10:35416472 CREM -0.44 -6.89 -0.35 2.74e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9297145 0.761 rs28545226 chr7:98732472 A/T cg05967295 chr7:98741636 SMURF1 0.97 14.54 0.62 1.84e-37 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs3617 0.573 rs56383738 chr3:52908398 T/C cg18099408 chr3:52552593 STAB1 0.35 5.75 0.3 2.05e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg24250549 chr1:154909240 PMVK 0.5 7.77 0.39 9.54e-14 Prostate cancer; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03352830 chr11:487213 PTDSS2 0.7 8.41 0.42 1.24e-15 Body mass index; LUSC cis rs9420 0.961 rs11604325 chr11:57497011 C/A cg23127183 chr11:57508653 C11orf31 -0.58 -8.91 -0.44 3.41e-17 Schizophrenia; LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg08219700 chr8:58056026 NA 0.64 8.25 0.41 3.79e-15 Developmental language disorder (linguistic errors); LUSC cis rs6964587 0.935 rs28412174 chr7:91577245 T/G cg22709100 chr7:91322751 NA -0.39 -5.78 -0.3 1.76e-8 Breast cancer; LUSC cis rs2074585 0.517 rs11635361 chr15:91081791 G/T cg22089800 chr15:90895588 ZNF774 -0.56 -7.97 -0.4 2.49e-14 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs3818285 0.959 rs35420248 chr10:111643074 C/T cg00817464 chr10:111662876 XPNPEP1 -0.65 -8.3 -0.41 2.56e-15 Superior crus of antihelix expression; LUSC cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg07606381 chr6:8435919 SLC35B3 0.72 12.16 0.55 2.03e-28 Motion sickness; LUSC trans rs61931739 0.517 rs56308002 chr12:34016021 C/G cg13010199 chr12:38710504 ALG10B 0.55 8.34 0.42 1.98e-15 Morning vs. evening chronotype; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg21235925 chr17:80678270 FN3KRP -0.35 -6.21 -0.32 1.55e-9 N-glycan levels; LUSC cis rs1403694 0.695 rs1836860 chr3:186436604 C/T cg12454167 chr3:186435060 KNG1 -0.31 -7.85 -0.39 5.79e-14 Blood protein levels; LUSC cis rs7582720 1.000 rs72928613 chr2:203839628 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.85e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs981844 0.922 rs75543972 chr4:154664792 G/C cg10279832 chr4:154682576 RNF175 -0.4 -5.85 -0.3 1.19e-8 Response to statins (LDL cholesterol change); LUSC trans rs11039798 0.841 rs11039783 chr11:48526828 G/C cg15704280 chr7:45808275 SEPT13 0.71 6.68 0.34 9.87e-11 Axial length; LUSC cis rs3770081 1.000 rs11899576 chr2:86256193 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -0.81 -5.86 -0.31 1.1e-8 Facial emotion recognition (sad faces); LUSC cis rs372883 0.935 rs379592 chr21:30706470 A/G cg08807101 chr21:30365312 RNF160 -0.41 -5.87 -0.31 1.07e-8 Pancreatic cancer; LUSC cis rs12824058 0.831 rs11608406 chr12:130805866 G/C cg23887609 chr12:130822674 PIWIL1 0.48 7.11 0.36 7.08e-12 Menopause (age at onset); LUSC cis rs5758511 0.680 rs5758698 chr22:42684818 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.49 -5.82 -0.3 1.39e-8 Birth weight; LUSC cis rs7089973 0.604 rs8181444 chr10:116588981 C/T cg03647239 chr10:116582469 FAM160B1 0.45 7.27 0.37 2.55e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg04871131 chr7:94954202 PON1 -0.38 -6.09 -0.32 3.12e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs4499344 0.633 rs259271 chr19:33157100 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.42 0.53 1.02e-25 Mean platelet volume; LUSC trans rs3942852 0.568 rs7479361 chr11:48109793 C/T cg03929089 chr4:120376271 NA -0.58 -7.59 -0.38 3.19e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs3892630 0.588 rs7245709 chr19:33242755 C/T cg22980127 chr19:33182716 NUDT19 0.9 12.86 0.58 5.17e-31 Red blood cell traits; LUSC cis rs12908161 0.959 rs34028043 chr15:85231585 G/A cg11189052 chr15:85197271 WDR73 0.48 5.93 0.31 7.56e-9 Schizophrenia; LUSC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg23281280 chr6:28129359 ZNF389 0.45 5.88 0.31 1.02e-8 Depression; LUSC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg13770153 chr20:60521292 NA -0.75 -10.4 -0.49 3.92e-22 Body mass index; LUSC trans rs6582630 0.519 rs4436613 chr12:38293653 T/C cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs2762353 0.904 rs13197601 chr6:25785935 G/A cg03264133 chr6:25882463 NA 0.42 7.23 0.37 3.36e-12 Blood metabolite levels; LUSC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg27121462 chr16:89883253 FANCA 0.55 8.86 0.44 4.78e-17 Vitiligo; LUSC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg10253484 chr15:75165896 SCAMP2 -0.45 -6.52 -0.34 2.67e-10 Breast cancer; LUSC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg02822958 chr2:46747628 ATP6V1E2 0.39 5.73 0.3 2.24e-8 Height; LUSC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg25019033 chr10:957182 NA -0.52 -6.56 -0.34 1.99e-10 Eosinophil percentage of granulocytes; LUSC cis rs9303401 0.659 rs34426768 chr17:56683385 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.17 0.58 3.41e-32 Cognitive test performance; LUSC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs3733418 0.929 rs12510464 chr4:165919040 A/G cg11630554 chr4:165878136 TRIM61;C4orf39 -0.52 -5.93 -0.31 7.69e-9 Obesity-related traits; LUSC cis rs17255340 0.520 rs3798885 chr6:84131874 T/C cg08257003 chr6:84140564 ME1 0.37 8.91 0.44 3.25e-17 Platelet-derived growth factor BB levels; LUSC cis rs56283067 0.847 rs10948156 chr6:44689459 G/A cg20913747 chr6:44695427 NA -0.48 -7.78 -0.39 9.29e-14 Total body bone mineral density; LUSC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.02 0.4 1.76e-14 Parkinson's disease; LUSC cis rs9303280 0.870 rs1011082 chr17:38068514 T/C cg10909506 chr17:38081995 ORMDL3 -0.35 -6.38 -0.33 5.86e-10 Self-reported allergy; LUSC cis rs7771547 0.508 rs1570368 chr6:36437136 C/G cg07856975 chr6:36356162 ETV7 0.4 6.66 0.34 1.15e-10 Platelet distribution width; LUSC trans rs7657257 1.000 rs4321629 chr4:15732380 C/T cg17675199 chr6:35436792 RPL10A -0.83 -6.11 -0.32 2.84e-9 Blood protein levels; LUSC cis rs8060686 0.641 rs113790673 chr16:68244347 C/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.68 -0.3 2.95e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg07701084 chr6:150067640 NUP43 0.53 7.85 0.39 5.88e-14 Lung cancer; LUSC cis rs12310956 0.532 rs11494810 chr12:33952881 C/A cg06521331 chr12:34319734 NA -0.47 -7.56 -0.38 3.82e-13 Morning vs. evening chronotype; LUSC trans rs9934935 1.000 rs9934935 chr16:82704528 G/A cg06378491 chr11:64564012 MAP4K2 -0.38 -5.97 -0.31 6.06e-9 Trans fatty acid levels; LUSC cis rs4930103 0.935 rs2071094 chr11:2021164 G/T cg23202291 chr11:1979235 NA 0.39 6.01 0.31 4.74e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs9925964 0.933 rs2303222 chr16:31085470 A/G cg02466173 chr16:30829666 NA 0.34 6.12 0.32 2.69e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2262909 0.962 rs12609368 chr19:22263996 T/C cg17074339 chr11:11642133 GALNTL4 0.47 7.2 0.37 3.93e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg05347473 chr6:146136440 FBXO30 0.51 8.78 0.43 8.73e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.41 0.42 1.23e-15 Height; LUSC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.22e-30 Aortic root size; LUSC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.47 -7.04 -0.36 1.12e-11 Alzheimer's disease (late onset); LUSC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg15782153 chr7:917662 C7orf20 -0.43 -6.65 -0.34 1.23e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs9399135 0.967 rs6909975 chr6:135315570 C/T cg24558204 chr6:135376177 HBS1L 0.58 8.83 0.44 5.98e-17 Red blood cell count; LUSC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg15744005 chr10:104629667 AS3MT -0.34 -7.07 -0.36 9.36e-12 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4853525 0.923 rs1882398 chr2:191724460 A/G cg11845111 chr2:191398756 TMEM194B -0.4 -5.87 -0.31 1.07e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg09877947 chr5:131593287 PDLIM4 0.39 6.61 0.34 1.52e-10 Blood metabolite levels; LUSC cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.82e-13 Motion sickness; LUSC trans rs2665103 0.715 rs11639440 chr15:82571046 G/A cg18393722 chr15:85113863 UBE2QP1 -0.46 -7.01 -0.36 1.28e-11 Intelligence (multi-trait analysis); LUSC cis rs644799 0.710 rs519511 chr11:95538270 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.86 0.6 8.34e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg00343986 chr7:65444356 GUSB 0.48 7.12 0.36 6.59e-12 Calcium levels; LUSC trans rs877282 0.583 rs11253424 chr10:813426 C/T cg13042288 chr15:90349979 ANPEP -0.38 -6.25 -0.32 1.25e-9 Uric acid levels; LUSC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg18904891 chr8:8559673 CLDN23 0.61 8.47 0.42 7.74e-16 Obesity-related traits; LUSC cis rs7267979 1.000 rs2500418 chr20:25382268 C/T cg03522245 chr20:25566470 NINL -0.35 -5.73 -0.3 2.21e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs243505 1.000 rs243511 chr7:148430148 A/C cg09806900 chr7:148480153 CUL1 -0.49 -6.92 -0.35 2.27e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12200560 0.505 rs211177 chr6:97074088 C/T cg06623918 chr6:96969491 KIAA0776 0.51 7.33 0.37 1.78e-12 Coronary heart disease; LUSC cis rs877426 0.645 rs2297103 chr13:114775816 G/T cg02745494 chr13:114771098 RASA3 0.38 5.82 0.3 1.41e-8 Facial morphology (factor 14, intercanthal width); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19596991 chr10:126432951 FAM53B 0.47 6.64 0.34 1.29e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11608355 0.557 rs759971 chr12:109826046 A/T cg19025524 chr12:109796872 NA -0.41 -7.6 -0.38 3.09e-13 Neuroticism; LUSC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.55 8.36 0.42 1.66e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs6561151 0.957 rs3764147 chr13:44457925 C/T cg12856521 chr11:46389249 DGKZ -0.57 -7.52 -0.38 4.99e-13 Crohn's disease; LUSC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg17264618 chr3:40429014 ENTPD3 0.33 6.93 0.35 2.23e-11 Renal cell carcinoma; LUSC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg07148914 chr20:33460835 GGT7 0.54 8.36 0.42 1.72e-15 Height; LUSC cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg26897989 chr16:1907736 C16orf73 -0.41 -6.58 -0.34 1.79e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg18876405 chr7:65276391 NA 0.55 8.81 0.43 6.74e-17 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11691170 chr11:130318691 ADAMTS15 -0.5 -6.69 -0.34 9.46e-11 Bipolar disorder and schizophrenia; LUSC cis rs60843830 0.661 rs11674477 chr2:105822 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.45 6.7 0.34 8.9e-11 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg13010199 chr12:38710504 ALG10B 0.49 7.62 0.38 2.72e-13 Morning vs. evening chronotype; LUSC cis rs10911232 0.507 rs10797832 chr1:183044034 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 10.96 0.51 4.32e-24 Hypertriglyceridemia; LUSC cis rs2095921 1 rs2095921 chr1:11033322 C/G cg02454025 chr1:11042201 C1orf127 1.03 18.67 0.71 8.68e-54 Male-pattern baldness; LUSC cis rs11792861 0.890 rs57387569 chr9:111920392 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.51 -0.34 2.82e-10 Menarche (age at onset); LUSC trans rs10506458 0.915 rs56321182 chr12:63392023 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -15.5 -0.65 3.23e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs79911532 0.515 rs80351761 chr7:75698945 G/A cg03592824 chr7:75666768 STYXL1 0.67 6.42 0.33 4.79e-10 Mononucleosis; LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg14004847 chr7:1930337 MAD1L1 -0.5 -7.66 -0.39 2.09e-13 Bipolar disorder and schizophrenia; LUSC cis rs1348850 0.602 rs1453373 chr2:178221668 G/A cg22681709 chr2:178499509 PDE11A -0.36 -6.68 -0.34 9.9e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg08280861 chr8:58055591 NA 0.54 5.89 0.31 9.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs2046867 0.818 rs17010215 chr3:72886965 A/G cg25664220 chr3:72788482 NA -0.66 -10.72 -0.51 3.15e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7267979 1.000 rs2482937 chr20:25340786 A/G cg08601574 chr20:25228251 PYGB -0.44 -6.78 -0.35 5.4e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4654899 0.965 rs4654907 chr1:21521094 C/T cg01072550 chr1:21505969 NA -0.57 -8.64 -0.43 2.34e-16 Superior frontal gyrus grey matter volume; LUSC cis rs4319547 0.695 rs10773103 chr12:122856532 A/G cg05707623 chr12:122985044 ZCCHC8 0.66 8.18 0.41 5.92e-15 Body mass index; LUSC trans rs11098499 0.954 rs13113483 chr4:120309039 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg16434002 chr17:42200994 HDAC5 0.44 5.84 0.3 1.21e-8 Total body bone mineral density; LUSC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9560113 0.960 rs4773378 chr13:112174154 G/A cg14154082 chr13:112174009 NA 0.38 7.95 0.4 2.97e-14 Menarche (age at onset); LUSC trans rs11039798 0.588 rs7483361 chr11:48593786 G/A cg15704280 chr7:45808275 SEPT13 0.64 7.26 0.37 2.71e-12 Axial length; LUSC cis rs11051970 0.838 rs2651369 chr12:32552769 C/G cg02745156 chr12:32552066 NA 0.41 7.08 0.36 8.33e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg13939156 chr17:80058883 NA 0.36 7.21 0.37 3.84e-12 Life satisfaction; LUSC cis rs1395 0.778 rs60631624 chr2:27497815 T/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 5.97 0.31 6.09e-9 Blood metabolite levels; LUSC cis rs2274273 0.901 rs112870553 chr14:55790062 T/G cg04306507 chr14:55594613 LGALS3 0.56 12.99 0.58 1.58e-31 Protein biomarker; LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg05368731 chr17:41323189 NBR1 0.94 16.46 0.67 5.38e-45 Menopause (age at onset); LUSC cis rs1561296 0.529 rs10497860 chr2:201272705 A/G cg23649088 chr2:200775458 C2orf69 0.39 6.05 0.31 3.95e-9 Schizophrenia; LUSC cis rs924607 1.000 rs1697978 chr5:642829 A/G cg09021430 chr5:549028 NA -0.41 -7.34 -0.37 1.61e-12 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg27446573 chr6:127587934 RNF146 0.92 15.23 0.64 3.94e-40 Breast cancer; LUSC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg21361702 chr7:150065534 REPIN1 0.59 8.61 0.43 3.02e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs9314323 0.767 rs7012604 chr8:26204089 G/A cg13160058 chr8:26243215 BNIP3L -0.39 -6.69 -0.34 9.59e-11 Red cell distribution width; LUSC cis rs2625529 0.652 rs2929532 chr15:72345110 C/T cg16672083 chr15:72433130 SENP8 0.49 8.19 0.41 5.72e-15 Red blood cell count; LUSC cis rs72960926 0.744 rs72964239 chr6:74874498 C/A cg03266952 chr6:74778945 NA -0.8 -6.4 -0.33 5.18e-10 Metabolite levels (MHPG); LUSC cis rs10782582 0.609 rs1770882 chr1:76411549 G/A cg03433033 chr1:76189801 ACADM -0.41 -6.1 -0.32 3.02e-9 Daytime sleep phenotypes; LUSC cis rs1559088 0.600 rs10421769 chr19:33605312 T/C cg17764715 chr19:33622953 WDR88 0.59 8.87 0.44 4.66e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs35094601 0.731 rs4954929 chr2:139212829 T/C cg10095539 chr2:139258744 SPOPL 0.25 5.86 0.31 1.13e-8 Schizophrenia; LUSC cis rs7481584 0.564 rs7948848 chr11:2981896 G/A cg08508325 chr11:3079039 CARS 0.33 6.57 0.34 1.95e-10 Calcium levels; LUSC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg22655196 chr4:3374909 RGS12 0.31 5.97 0.31 6.14e-9 Serum sulfate level; LUSC cis rs4722585 0.533 rs2237335 chr7:26200213 A/G cg07876897 chr7:26191696 NFE2L3 0.46 6.87 0.35 3.15e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg07636037 chr3:49044803 WDR6 0.46 6.51 0.34 2.81e-10 Resting heart rate; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg04234412 chr22:24373322 LOC391322 -0.83 -13.55 -0.6 1.25e-33 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1018836 0.892 rs2187981 chr8:91549629 T/C cg16814680 chr8:91681699 NA -0.7 -11.5 -0.53 5.21e-26 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7180079 1.000 rs7165405 chr15:64662900 C/T cg08069370 chr15:64387884 SNX1 -0.56 -6.06 -0.31 3.68e-9 Monocyte count; LUSC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC trans rs11039798 0.841 rs7950737 chr11:48590678 T/G cg15704280 chr7:45808275 SEPT13 0.69 6.45 0.33 3.92e-10 Axial length; LUSC cis rs929354 0.806 rs28446734 chr7:156996775 T/C cg05182265 chr7:156933206 UBE3C -0.58 -9.33 -0.45 1.55e-18 Body mass index; LUSC cis rs9326248 0.559 rs4938334 chr11:116931042 G/C cg11861562 chr11:117069780 TAGLN 0.33 6.38 0.33 5.8e-10 Blood protein levels; LUSC cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg11752832 chr7:134001865 SLC35B4 0.5 7.23 0.37 3.39e-12 Mean platelet volume; LUSC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg13393036 chr8:95962371 TP53INP1 -0.47 -9.69 -0.47 9.74e-20 Type 2 diabetes; LUSC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg08470875 chr2:26401718 FAM59B -0.68 -9.08 -0.45 9.33e-18 Gut microbiome composition (summer); LUSC cis rs79247733 1.000 rs79247733 chr22:30757436 G/A cg03868770 chr22:30783737 RNF215 -0.52 -5.93 -0.31 7.6e-9 Tonsillectomy; LUSC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.73 0.39 1.24e-13 Alzheimer's disease; LUSC cis rs9905704 0.918 rs35934668 chr17:56894638 A/G cg12560992 chr17:57184187 TRIM37 0.55 7.84 0.39 6.19e-14 Testicular germ cell tumor; LUSC cis rs10779751 0.734 rs6701726 chr1:11126941 C/T cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg16423285 chr20:60520624 NA -0.47 -5.92 -0.31 8.15e-9 Body mass index; LUSC cis rs6582630 0.573 rs12319414 chr12:38267440 T/C cg13010199 chr12:38710504 ALG10B -0.47 -6.98 -0.36 1.63e-11 Drug-induced liver injury (flucloxacillin); LUSC trans rs1325195 0.506 rs2636266 chr1:179199652 A/G cg11624085 chr17:8464688 MYH10 0.43 6.38 0.33 5.94e-10 IgE grass sensitization; LUSC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg07212818 chr11:638076 DRD4 -0.46 -7.61 -0.38 2.74e-13 Systemic lupus erythematosus; LUSC cis rs796364 0.806 rs79897806 chr2:201073968 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.97 -0.4 2.56e-14 Schizophrenia; LUSC cis rs295140 0.803 rs4233994 chr2:201129211 G/C cg04283868 chr2:201171347 SPATS2L 0.41 5.95 0.31 6.78e-9 QT interval; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21829265 chr6:56911139 KIAA1586 0.39 6.27 0.32 1.11e-9 Triglycerides; LUSC trans rs10506458 0.915 rs12423078 chr12:63397529 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.02 -0.63 2.6e-39 Hemostatic factors and hematological phenotypes; LUSC cis rs55871839 0.708 rs10093993 chr8:59811454 T/C cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.94 0.51 5.25e-24 Menopause (age at onset); LUSC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9815354 0.767 rs60764195 chr3:41812522 G/C cg03022575 chr3:42003672 ULK4 0.85 8.67 0.43 1.87e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg23625390 chr15:77176239 SCAPER 0.45 6.95 0.36 1.89e-11 Blood metabolite levels; LUSC cis rs7255 0.545 rs9306894 chr2:20878105 A/G cg05481257 chr2:20870211 GDF7 -0.34 -5.99 -0.31 5.4e-9 Barrett's esophagus or Esophageal adenocarcinoma;Esophageal adenocarcinoma; LUSC trans rs853679 0.546 rs36116761 chr6:27818482 C/G cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.13e-9 Depression; LUSC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg24531977 chr5:56204891 C5orf35 -1.02 -15.52 -0.65 2.71e-41 Initial pursuit acceleration; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg18538332 chr22:24372958 LOC391322 -0.47 -8.25 -0.41 3.64e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg26924012 chr15:45694286 SPATA5L1 1.13 20.84 0.75 2.15e-62 Homoarginine levels; LUSC trans rs4332037 0.950 rs10267593 chr7:1937261 G/A cg10840412 chr1:235813424 GNG4 0.6 8.42 0.42 1.15e-15 Bipolar disorder; LUSC cis rs9467773 1.000 rs6926629 chr6:26499903 T/C cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.09e-18 Intelligence (multi-trait analysis); LUSC cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg05868516 chr6:26286170 HIST1H4H 0.36 5.89 0.31 9.34e-9 Educational attainment; LUSC trans rs1994135 0.630 rs11052757 chr12:33719879 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.12 0.48 3.66e-21 Resting heart rate; LUSC trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg03929089 chr4:120376271 NA -0.74 -10.02 -0.48 7.92e-21 Coronary artery disease; LUSC cis rs34779708 0.897 rs4934529 chr10:35302376 T/A cg03585969 chr10:35415529 CREM 0.64 9.18 0.45 4.74e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7180079 1.000 rs4777181 chr15:64670566 T/C cg08069370 chr15:64387884 SNX1 0.58 6.18 0.32 1.84e-9 Monocyte count; LUSC cis rs1008375 1.000 rs9291659 chr4:17662360 A/C cg18681998 chr4:17616180 MED28 0.86 15.66 0.65 7.88e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9790314 0.521 rs1450523 chr3:161077270 G/A cg03342759 chr3:160939853 NMD3 -0.4 -5.91 -0.31 8.38e-9 Morning vs. evening chronotype; LUSC cis rs4654899 0.802 rs10916903 chr1:21247944 T/C cg01072550 chr1:21505969 NA -0.52 -7.54 -0.38 4.52e-13 Superior frontal gyrus grey matter volume; LUSC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.46 0.38 7.44e-13 Cognitive function; LUSC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg11301795 chr4:187892539 NA -0.81 -16.0 -0.66 3.69e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs62400317 0.859 rs55964727 chr6:45259079 A/C cg20913747 chr6:44695427 NA -0.45 -7.42 -0.38 9.97e-13 Total body bone mineral density; LUSC trans rs61931739 0.517 rs12816252 chr12:34067693 G/A cg26384229 chr12:38710491 ALG10B 0.73 11.48 0.53 5.99e-26 Morning vs. evening chronotype; LUSC cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg18252515 chr7:66147081 NA -1.2 -13.16 -0.58 3.72e-32 Diabetic kidney disease; LUSC cis rs4629710 0.592 rs9492865 chr6:131534403 T/A cg12606694 chr6:131520996 AKAP7 0.6 8.99 0.44 1.94e-17 Multiple myeloma (IgH translocation); LUSC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg12432903 chr7:1882776 MAD1L1 0.53 6.63 0.34 1.33e-10 Bipolar disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02396668 chr19:50528878 VRK3;ZNF473 0.45 6.74 0.35 7e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg11887960 chr12:57824829 NA 0.57 7.03 0.36 1.18e-11 Lung disease severity in cystic fibrosis; LUSC cis rs2235649 0.828 rs9925354 chr16:1849866 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.44 -6.04 -0.31 4.12e-9 Blood metabolite levels; LUSC cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg09479241 chr17:27052676 TLCD1 0.43 5.96 0.31 6.29e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs5839475 1 rs5839475 chr2:234188015 A/AG cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.58 8.12 0.41 9.05e-15 Strep throat; LUSC trans rs10492201 0.529 rs11176998 chr12:68387554 T/G cg21566642 chr2:233284661 NA -0.39 -6.03 -0.31 4.28e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs9325144 0.624 rs7979541 chr12:39129679 T/C cg26384229 chr12:38710491 ALG10B -0.59 -9.13 -0.45 6.6e-18 Morning vs. evening chronotype; LUSC cis rs9660992 0.674 rs72745221 chr1:205262337 G/A cg00857998 chr1:205179979 DSTYK 0.62 9.52 0.46 3.48e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1595825 0.891 rs76637837 chr2:198529496 G/A cg19156104 chr2:198669113 PLCL1 -0.45 -5.69 -0.3 2.74e-8 Ulcerative colitis; LUSC cis rs67072384 0.892 rs72966136 chr11:72456710 G/C cg04827223 chr11:72435913 ARAP1 -0.82 -6.71 -0.34 8.49e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs2652834 0.851 rs10851723 chr15:63416335 G/T cg05507819 chr15:63340323 TPM1 0.45 5.8 0.3 1.58e-8 HDL cholesterol; LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.01 0.31 4.87e-9 Menopause (age at onset); LUSC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg08999081 chr20:33150536 PIGU 0.53 10.54 0.5 1.32e-22 Glomerular filtration rate (creatinine); LUSC cis rs2204008 0.575 rs10444564 chr12:38043782 T/C cg13010199 chr12:38710504 ALG10B 0.71 10.9 0.51 7.24e-24 Bladder cancer; LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg25067162 chr17:41277974 BRCA1;NBR2 -0.37 -6.08 -0.32 3.26e-9 Menopause (age at onset); LUSC cis rs765787 0.530 rs12915027 chr15:45512626 G/A cg25801113 chr15:45476975 SHF -0.32 -6.43 -0.33 4.34e-10 Uric acid levels; LUSC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg08499158 chr17:42289980 UBTF 0.42 6.34 0.33 7.29e-10 Total body bone mineral density; LUSC cis rs72781680 0.848 rs56371415 chr2:23932603 C/G cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.48e-12 Lymphocyte counts; LUSC cis rs7264396 0.790 rs6060530 chr20:34227663 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.97 -0.48 1.13e-20 Total cholesterol levels; LUSC cis rs17095355 0.605 rs7075964 chr10:111631265 G/T cg00817464 chr10:111662876 XPNPEP1 -0.55 -6.5 -0.34 2.92e-10 Biliary atresia; LUSC cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.46e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs3960554 0.808 rs2302434 chr7:75630183 C/T cg19862616 chr7:65841803 NCRNA00174 0.87 10.19 0.49 2.01e-21 Eotaxin levels; LUSC cis rs10744422 1.000 rs4759355 chr12:123316566 A/G cg25930673 chr12:123319894 HIP1R -0.63 -6.17 -0.32 2.01e-9 Schizophrenia; LUSC cis rs9527 0.590 rs2182348 chr10:104872684 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg05253716 chr12:129299332 SLC15A4;MGC16384 0.42 6.33 0.33 7.87e-10 Systemic lupus erythematosus; LUSC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg21724239 chr8:58056113 NA 0.94 15.2 0.64 4.91e-40 Developmental language disorder (linguistic errors); LUSC cis rs62400317 0.859 rs4479922 chr6:45248371 T/C cg18551225 chr6:44695536 NA -0.44 -7.21 -0.37 3.75e-12 Total body bone mineral density; LUSC cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg08085267 chr17:45401833 C17orf57 -0.47 -6.66 -0.34 1.11e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12940923 1.000 rs12949848 chr17:56362067 A/G cg19466818 chr17:56409534 MIR142 -0.39 -6.86 -0.35 3.35e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs1775715 0.870 rs1775731 chr10:32253512 A/G cg26784012 chr10:32216390 ARHGAP12 0.41 6.56 0.34 2.02e-10 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs12310956 0.515 rs1830086 chr12:33958874 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.41 0.42 1.19e-15 Morning vs. evening chronotype; LUSC trans rs7746199 0.736 rs34965299 chr6:27521856 A/G cg06606381 chr12:133084897 FBRSL1 -0.92 -8.91 -0.44 3.3e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1691799 0.867 rs1168339 chr12:66759236 T/G cg16791601 chr12:66731901 HELB -0.71 -12.37 -0.56 3.47e-29 White blood cell count (basophil); LUSC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg23630131 chr7:65973040 NA 0.22 6.2 0.32 1.7e-9 Aortic root size; LUSC cis rs7843479 0.601 rs1031882 chr8:21788934 T/G cg17168535 chr8:21777572 XPO7 0.85 15.76 0.65 3.13e-42 Mean corpuscular volume; LUSC trans rs62458065 0.713 rs62463968 chr7:32501242 G/A cg00845942 chr12:64062724 DPY19L2 -0.56 -6.75 -0.35 6.42e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 6.47 0.33 3.5e-10 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27199889 chr11:58910235 FAM111A -0.42 -6.03 -0.31 4.25e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC cis rs6964587 0.904 rs2023785 chr7:91547369 C/A cg17063962 chr7:91808500 NA -0.53 -8.1 -0.41 1.01e-14 Breast cancer; LUSC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg09555818 chr19:45449301 APOC2 0.44 8.18 0.41 5.99e-15 Blood protein levels; LUSC cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg08807101 chr21:30365312 RNF160 -0.53 -7.91 -0.4 3.87e-14 Dental caries; LUSC cis rs7744392 0.557 rs12211943 chr6:35306857 G/A cg06087101 chr6:35551932 FKBP5 0.47 5.77 0.3 1.82e-8 Cataracts in type 2 diabetes; LUSC cis rs34779708 0.733 rs4391768 chr10:35547595 A/G cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2439831 0.717 rs9806227 chr15:43680115 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.04 12.58 0.57 5.75e-30 Lung cancer in ever smokers; LUSC cis rs243505 1.000 rs243502 chr7:148437205 C/T cg09806900 chr7:148480153 CUL1 -0.5 -7.01 -0.36 1.35e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs41271473 1.000 rs41270187 chr1:228878871 T/C cg10167378 chr1:228756711 NA 0.51 6.32 0.33 8.24e-10 Chronic lymphocytic leukemia; LUSC cis rs10771431 0.597 rs3759275 chr12:9353828 A/T cg08997352 chr12:9597637 DDX12 -0.71 -11.07 -0.52 1.83e-24 Breast size; LUSC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg15147215 chr3:52552868 STAB1 -0.29 -5.83 -0.3 1.28e-8 Bipolar disorder; LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg04267008 chr7:1944627 MAD1L1 -0.5 -7.36 -0.37 1.42e-12 Bipolar disorder and schizophrenia; LUSC cis rs7267979 0.714 rs3787082 chr20:25235736 A/T cg08601574 chr20:25228251 PYGB 0.48 7.45 0.38 8.3e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg05340658 chr4:99064831 C4orf37 0.63 9.85 0.47 2.88e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs2243480 1.000 rs906134 chr7:65444288 G/C cg10756647 chr7:56101905 PSPH 0.86 8.36 0.42 1.7e-15 Diabetic kidney disease; LUSC cis rs748404 0.578 rs510108 chr15:43605439 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.61 9.42 0.46 7.41e-19 Lung cancer; LUSC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg22782873 chr19:19639568 YJEFN3 -0.47 -6.12 -0.32 2.65e-9 Bipolar disorder; LUSC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.35 -0.42 1.88e-15 Coronary artery disease; LUSC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg08677398 chr8:58056175 NA 0.52 6.95 0.36 1.88e-11 Developmental language disorder (linguistic errors); LUSC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.88 0.31 1.02e-8 Schizophrenia; LUSC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg21770322 chr7:97807741 LMTK2 0.4 7.03 0.36 1.19e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs11785400 0.762 rs4401833 chr8:143739731 A/T cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg20503657 chr10:835505 NA 0.89 12.37 0.56 3.37e-29 Eosinophil percentage of granulocytes; LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 6.92 0.35 2.33e-11 Platelet count; LUSC cis rs11229555 0.645 rs12269928 chr11:58184358 T/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs16854884 1.000 rs2370171 chr3:143765177 C/T cg06585982 chr3:143692056 C3orf58 0.49 7.0 0.36 1.44e-11 Economic and political preferences (feminism/equality); LUSC cis rs1878931 0.543 rs1129568 chr16:3483475 G/A cg22508957 chr16:3507546 NAT15 -0.42 -6.33 -0.33 7.95e-10 Body mass index (adult); LUSC cis rs9462027 0.583 rs2814947 chr6:34653268 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.16 -0.32 2.13e-9 Systemic lupus erythematosus; LUSC cis rs1461503 0.932 rs10892944 chr11:122843895 T/C cg27398637 chr11:122830231 C11orf63 -0.42 -6.73 -0.35 7.37e-11 Menarche (age at onset); LUSC cis rs7091068 0.706 rs1147645 chr10:95401241 C/G cg20715218 chr10:95462985 C10orf4 -0.63 -6.31 -0.33 8.9e-10 Urinary tract infection frequency; LUSC cis rs7712401 0.601 rs30039 chr5:122277179 A/C cg19077854 chr5:122220652 SNX24 -0.42 -8.64 -0.43 2.35e-16 Mean platelet volume; LUSC cis rs17253792 0.915 rs75296402 chr14:56182491 C/T cg01858014 chr14:56050164 KTN1 -0.86 -6.91 -0.35 2.43e-11 Putamen volume; LUSC cis rs11098499 0.954 rs11098526 chr4:120390359 C/T cg09307838 chr4:120376055 NA 0.78 11.21 0.52 5.78e-25 Corneal astigmatism; LUSC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg03929089 chr4:120376271 NA -0.94 -14.97 -0.63 4.03e-39 Coronary artery disease; LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -11.83 -0.54 3.43e-27 Platelet count; LUSC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg06505273 chr16:24850292 NA -0.41 -5.74 -0.3 2.16e-8 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.08 -0.32 3.35e-9 Major depressive disorder; LUSC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg12463550 chr7:65579703 CRCP -0.51 -7.49 -0.38 6.15e-13 Aortic root size; LUSC cis rs9840812 0.773 rs61789601 chr3:135954979 C/T cg15507776 chr3:136538369 TMEM22 -0.44 -5.77 -0.3 1.77e-8 Fibrinogen levels; LUSC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg02034447 chr16:89574710 SPG7 0.42 6.14 0.32 2.33e-9 Multiple myeloma (IgH translocation); LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18758796 chr5:131593413 PDLIM4 0.53 9.16 0.45 5.21e-18 Acylcarnitine levels; LUSC trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg15704280 chr7:45808275 SEPT13 0.86 11.39 0.53 1.35e-25 Coronary artery disease; LUSC cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg02423579 chr7:2872169 GNA12 -0.37 -5.71 -0.3 2.52e-8 Height; LUSC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg02807482 chr3:125708958 NA -0.49 -6.1 -0.32 3.01e-9 Blood pressure (smoking interaction); LUSC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6087990 0.735 rs6057647 chr20:31381690 A/T cg13636640 chr20:31349939 DNMT3B 0.91 18.47 0.71 5.77e-53 Ulcerative colitis; LUSC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg00339695 chr16:24857497 SLC5A11 0.61 9.21 0.45 3.58e-18 Intelligence (multi-trait analysis); LUSC cis rs7020830 1.000 rs7020830 chr9:37085184 A/T cg14294708 chr9:37120828 ZCCHC7 1.08 23.42 0.79 1.91e-72 Schizophrenia; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg24739457 chr1:205821442 NA 0.35 6.02 0.31 4.66e-9 Menarche (age at onset); LUSC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg09365446 chr1:150670422 GOLPH3L 0.5 7.4 0.38 1.08e-12 Melanoma; LUSC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.88 -0.4 4.81e-14 Blood metabolite levels; LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 12.88 0.58 4.13e-31 Platelet count; LUSC cis rs977987 0.735 rs11149831 chr16:75451461 G/A cg03315344 chr16:75512273 CHST6 0.54 9.78 0.47 5.17e-20 Dupuytren's disease; LUSC cis rs3768617 0.811 rs4396114 chr1:183007441 C/T ch.1.3577855R chr1:183094577 LAMC1 0.6 8.54 0.42 4.75e-16 Fuchs's corneal dystrophy; LUSC cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg14500267 chr11:67383377 NA -0.32 -5.81 -0.3 1.44e-8 Mean corpuscular volume; LUSC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs5758511 0.680 rs5758662 chr22:42628088 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.47 -5.83 -0.3 1.31e-8 Birth weight; LUSC cis rs9649213 0.574 rs17436977 chr7:97883459 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.41 -7.26 -0.37 2.79e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.96 0.51 4.51e-24 Menopause (age at onset); LUSC cis rs4478858 0.735 rs4494186 chr1:31857847 G/A cg00250761 chr1:31883323 NA 0.33 7.78 0.39 9.16e-14 Alcohol dependence; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10729317 chr20:2821390 FAM113A;VPS16 -0.47 -6.39 -0.33 5.49e-10 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg23835219 chr4:1244017 CTBP1;C4orf42 0.31 5.85 0.3 1.16e-8 Obesity-related traits; LUSC cis rs7954584 0.583 rs10770186 chr12:122361412 A/G cg13699009 chr12:122356056 WDR66 0.45 6.79 0.35 5e-11 Mean corpuscular volume; LUSC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg06481639 chr22:41940642 POLR3H 0.51 5.85 0.3 1.19e-8 Vitiligo; LUSC cis rs11190604 0.767 rs3829162 chr10:102172752 T/G cg07080220 chr10:102295463 HIF1AN 0.6 7.75 0.39 1.1e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg01973587 chr1:228161476 NA -0.4 -7.24 -0.37 3.09e-12 Diastolic blood pressure; LUSC trans rs853679 0.546 rs200990 chr6:27815823 T/G cg01620082 chr3:125678407 NA -0.7 -7.18 -0.37 4.47e-12 Depression; LUSC cis rs11122272 0.735 rs2572263 chr1:231509408 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs11792861 0.781 rs72607158 chr9:111763010 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.22 0.41 4.67e-15 Menarche (age at onset); LUSC cis rs418053 0.648 rs204228 chr6:13680776 A/G cg02206980 chr6:13574034 SIRT5 -0.29 -5.69 -0.3 2.75e-8 Breast cancer; LUSC cis rs10779751 0.734 rs910660 chr1:11130643 C/T cg08854313 chr1:11322531 MTOR -0.82 -12.72 -0.57 1.73e-30 Body mass index; LUSC cis rs7851660 0.844 rs10123699 chr9:100637859 A/G cg13688889 chr9:100608707 NA -0.55 -8.52 -0.42 5.57e-16 Strep throat; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg16132339 chr22:24313637 DDTL;DDT -0.4 -6.17 -0.32 1.94e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg03676636 chr4:99064102 C4orf37 0.38 7.92 0.4 3.55e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs7618501 0.633 rs2252833 chr3:50004209 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.82 0.43 6.29e-17 Intelligence (multi-trait analysis); LUSC cis rs2295359 0.892 rs10889657 chr1:67615487 A/G cg03340356 chr1:67600835 NA 0.46 7.38 0.37 1.27e-12 Psoriasis; LUSC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg22834771 chr12:69754056 YEATS4 0.43 6.66 0.34 1.1e-10 Blood protein levels; LUSC cis rs4660306 0.614 rs781057 chr1:45936017 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.42 5.8 0.3 1.55e-8 Homocysteine levels; LUSC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg12639453 chr1:2035780 PRKCZ -0.33 -7.16 -0.36 5.3e-12 Height; LUSC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg22029157 chr1:209979665 IRF6 0.8 10.25 0.49 1.27e-21 Cleft lip with or without cleft palate; LUSC cis rs9287719 0.934 rs6432110 chr2:10738018 T/A cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs4665809 0.590 rs11126339 chr2:26253223 T/C cg26314531 chr2:26401878 FAM59B -0.55 -7.23 -0.37 3.3e-12 Gut microbiome composition (summer); LUSC cis rs12930096 1.000 rs12929430 chr16:11679467 C/T cg07439791 chr16:11680400 LITAF 0.53 5.78 0.3 1.71e-8 QT interval; LUSC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs10504073 0.584 rs10504070 chr8:49978554 A/G cg00325661 chr8:49890786 NA -0.68 -11.09 -0.52 1.5e-24 Blood metabolite ratios; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg12564285 chr5:131593104 PDLIM4 -0.47 -8.21 -0.41 4.79e-15 Breast cancer; LUSC trans rs2679649 1.000 rs2684272 chr6:122351593 G/A cg00167820 chr8:131663355 NA 0.54 6.35 0.33 6.96e-10 Subcutaneous adipose tissue; LUSC cis rs11229555 0.645 rs12290089 chr11:58176849 A/G cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs3960554 0.808 rs13438599 chr7:75768022 G/A cg19862616 chr7:65841803 NCRNA00174 0.89 9.85 0.47 2.86e-20 Eotaxin levels; LUSC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg07395648 chr5:131743802 NA -0.44 -6.87 -0.35 3.12e-11 Breast cancer;Mosquito bite size; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg20814355 chr7:44646092 OGDH 0.5 6.34 0.33 7.26e-10 Response to Homoharringtonine (cytotoxicity); LUSC trans rs4332037 0.522 rs4721098 chr7:1881527 G/C cg25206134 chr2:45395956 NA -0.53 -6.32 -0.33 8.23e-10 Bipolar disorder; LUSC cis rs9309473 0.607 rs7567343 chr2:73596605 C/A cg20560298 chr2:73613845 ALMS1 -0.57 -8.42 -0.42 1.15e-15 Metabolite levels; LUSC cis rs926938 0.765 rs1884296 chr1:115235716 A/C cg12756093 chr1:115239321 AMPD1 -0.53 -8.1 -0.41 1.02e-14 Autism; LUSC cis rs4660306 0.961 rs4660860 chr1:45946233 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -7.09 -0.36 7.98e-12 Homocysteine levels; LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg14004847 chr7:1930337 MAD1L1 -0.52 -7.89 -0.4 4.32e-14 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg07936489 chr17:37558343 FBXL20 0.72 9.94 0.48 1.45e-20 Glomerular filtration rate (creatinine); LUSC cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg16482183 chr6:26056742 HIST1H1C 0.54 8.09 0.4 1.12e-14 Height; LUSC cis rs2463822 0.920 rs72923207 chr11:62117959 A/G cg06239285 chr11:62104954 ASRGL1 -0.97 -10.27 -0.49 1.1e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -8.12 -0.41 8.81e-15 Bone mineral density; LUSC cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg08085267 chr17:45401833 C17orf57 0.54 8.86 0.44 4.76e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2279817 0.954 rs12143113 chr1:18018857 T/C cg21791023 chr1:18019539 ARHGEF10L 0.53 6.93 0.35 2.24e-11 Neuroticism; LUSC trans rs1391576 1 rs1391576 chr11:51394932 C/T cg15704280 chr7:45808275 SEPT13 0.72 6.37 0.33 6.35e-10 Body mass index; LUSC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22590775 chr19:49891494 CCDC155 0.61 8.69 0.43 1.6e-16 Multiple sclerosis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02473350 chr3:160939232 NMD3 0.75 5.97 0.31 6.07e-9 Cognitive performance; LUSC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg18252515 chr7:66147081 NA -1.25 -13.99 -0.61 2.56e-35 Diabetic kidney disease; LUSC cis rs9837602 1.000 rs793496 chr3:99507254 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -6.02 -0.31 4.66e-9 Breast cancer; LUSC trans rs1697137 0.622 rs2545395 chr5:66380379 T/C cg12187567 chr8:95907389 CCNE2 0.48 6.02 0.31 4.59e-9 Carotid atherosclerosis in HIV infection; LUSC cis rs9916302 0.861 rs11078913 chr17:37671714 G/T cg15445000 chr17:37608096 MED1 0.4 6.85 0.35 3.65e-11 Glomerular filtration rate (creatinine); LUSC cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg13010199 chr12:38710504 ALG10B 0.49 7.5 0.38 6e-13 Morning vs. evening chronotype; LUSC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg17971929 chr21:40555470 PSMG1 -0.51 -7.65 -0.39 2.24e-13 Menarche (age at onset); LUSC cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg02527881 chr3:46936655 PTH1R -0.39 -6.94 -0.36 2.05e-11 Colorectal cancer; LUSC cis rs11792861 0.541 rs838824 chr9:111670707 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.45 -6.98 -0.36 1.55e-11 Menarche (age at onset); LUSC cis rs17818399 0.926 rs35350086 chr2:46834036 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.47 -6.23 -0.32 1.37e-9 Height; LUSC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.88e-19 Developmental language disorder (linguistic errors); LUSC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.4 8.41 0.42 1.19e-15 Autism spectrum disorder or schizophrenia; LUSC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs4704187 0.687 rs10214239 chr5:74357475 G/A cg03227963 chr5:74354835 NA 0.33 7.03 0.36 1.17e-11 Response to amphetamines; LUSC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs80282103 0.764 rs10047383 chr10:1103095 A/G cg23359895 chr10:1095482 IDI1 0.64 5.76 0.3 1.88e-8 Glomerular filtration rate (creatinine); LUSC cis rs847577 0.630 rs6969384 chr7:97732842 C/T cg21770322 chr7:97807741 LMTK2 0.55 9.86 0.47 2.74e-20 Breast cancer; LUSC cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg08999081 chr20:33150536 PIGU 0.54 10.96 0.51 4.22e-24 Coronary artery disease; LUSC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg06453172 chr10:134556979 INPP5A -0.51 -6.39 -0.33 5.41e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs637571 0.510 rs10750772 chr11:65577427 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -6.03 -0.31 4.43e-9 Eosinophil percentage of white cells; LUSC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg04369109 chr6:150039330 LATS1 -0.56 -8.29 -0.41 2.81e-15 Lung cancer; LUSC cis rs7615952 0.611 rs7632305 chr3:125634767 C/T cg05084668 chr3:125655381 ALG1L -0.92 -13.12 -0.58 5.09e-32 Blood pressure (smoking interaction); LUSC cis rs9399135 0.967 rs9376082 chr6:135346389 T/A cg22676075 chr6:135203613 NA 0.48 7.5 0.38 5.74e-13 Red blood cell count; LUSC cis rs2041895 0.509 rs12368448 chr12:107316796 A/C cg13944111 chr12:107296891 NA -0.38 -6.71 -0.34 8.42e-11 Glaucoma (low intraocular pressure); LUSC trans rs1994135 0.715 rs10844624 chr12:33691010 A/G cg13010199 chr12:38710504 ALG10B 0.54 7.84 0.39 6.24e-14 Resting heart rate; LUSC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -7.32 -0.37 1.86e-12 Developmental language disorder (linguistic errors); LUSC cis rs10193935 0.792 rs10204778 chr2:42498121 G/T cg27598129 chr2:42591480 NA -0.6 -8.1 -0.41 1.03e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs926392 0.572 rs6129157 chr20:37672247 G/T cg16355469 chr20:37678765 NA 0.52 6.95 0.36 1.9e-11 Dialysis-related mortality; LUSC cis rs6964587 0.900 rs62467794 chr7:91850578 C/T cg17063962 chr7:91808500 NA 0.57 8.43 0.42 1.06e-15 Breast cancer; LUSC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg04414720 chr1:150670196 GOLPH3L 0.51 7.88 0.4 4.63e-14 Melanoma; LUSC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg17366294 chr4:99064904 C4orf37 0.57 10.0 0.48 9.03e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs877282 0.838 rs11253408 chr10:796374 T/C cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs2046867 0.862 rs2322612 chr3:72830058 A/G cg25664220 chr3:72788482 NA -0.69 -11.99 -0.55 8.28e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2839186 0.934 rs17182538 chr21:47705673 C/A cg11766577 chr21:47581405 C21orf56 -0.41 -5.97 -0.31 6.03e-9 Testicular germ cell tumor; LUSC cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg04545296 chr12:48745243 ZNF641 0.37 6.72 0.35 7.87e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs11577318 0.579 rs11583205 chr1:26684141 C/A cg00852783 chr1:26633632 UBXN11 -0.51 -7.1 -0.36 7.4e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.55 0.46 2.95e-19 Prudent dietary pattern; LUSC trans rs11098499 0.618 rs6858383 chr4:120296772 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.21e-9 Corneal astigmatism; LUSC cis rs1712517 0.740 rs11191643 chr10:105057561 C/G cg05636881 chr10:105038444 INA 0.39 6.33 0.33 7.69e-10 Migraine; LUSC cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg26597838 chr10:835615 NA 0.89 12.27 0.56 8.26e-29 Eosinophil percentage of granulocytes; LUSC cis rs2836633 0.895 rs991816 chr21:40042150 C/A cg12884169 chr21:40033163 ERG 0.61 12.41 0.56 2.5e-29 Coronary artery disease; LUSC cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg25251562 chr2:3704773 ALLC 0.54 8.17 0.41 6.53e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -11.87 -0.54 2.4200000000000002e-27 Platelet count; LUSC cis rs2439831 0.867 rs2584702 chr15:43684914 C/A cg02155558 chr15:43621948 ADAL;LCMT2 1.04 12.58 0.57 5.75e-30 Lung cancer in ever smokers; LUSC cis rs7949030 0.964 rs2957122 chr11:62392100 G/C cg13298116 chr11:62369859 EML3;MTA2 -0.52 -8.68 -0.43 1.75e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7772486 0.875 rs10872582 chr6:146373061 G/A cg23711669 chr6:146136114 FBXO30 0.85 15.28 0.64 2.33e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs4713675 0.505 rs2395450 chr6:33654588 C/T cg14003231 chr6:33640908 ITPR3 0.32 6.11 0.32 2.85e-9 Plateletcrit; LUSC cis rs12220238 1.000 rs10824129 chr10:76008855 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.18e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg08859206 chr1:53392774 SCP2 -0.57 -9.95 -0.48 1.33e-20 Monocyte count; LUSC trans rs488628 0.848 rs1083825 chr3:118136831 A/T cg06621744 chr14:37052470 NKX2-8 -0.25 -5.96 -0.31 6.42e-9 White matter integrity (bipolar disorder risk interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08115069 chr19:55866329 COX6B2;FAM71E2 -0.49 -6.21 -0.32 1.59e-9 Bipolar disorder and schizophrenia; LUSC trans rs12579753 0.879 rs35087297 chr12:82133398 C/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.57 -0.34 1.88e-10 Resting heart rate; LUSC cis rs243505 0.898 rs243543 chr7:148402984 C/G cg09806900 chr7:148480153 CUL1 -0.47 -6.76 -0.35 6.01e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs227833 1.000 rs227830 chr6:44680555 G/C cg20913747 chr6:44695427 NA 0.38 5.77 0.3 1.82e-8 Monobrow; LUSC trans rs11148252 0.514 rs9526843 chr13:52730056 C/T cg18335740 chr13:41363409 SLC25A15 0.47 6.83 0.35 4.12e-11 Lewy body disease; LUSC cis rs4961252 0.505 rs6990155 chr8:142098977 C/T cg09914555 chr8:142094789 NA 0.49 7.47 0.38 6.88e-13 Isovolumetric relaxation time;Response to interferon beta therapy; LUSC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg16414030 chr3:133502952 NA -0.39 -5.71 -0.3 2.47e-8 Iron status biomarkers; LUSC cis rs240764 0.658 rs1336251 chr6:101247698 C/T cg09795085 chr6:101329169 ASCC3 -0.46 -6.65 -0.34 1.18e-10 Neuroticism; LUSC cis rs1372520 0.745 rs2736994 chr4:90784528 A/G cg15133208 chr4:90757351 SNCA -0.52 -7.75 -0.39 1.15e-13 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16676300 chr1:155658576 YY1AP1;DAP3 0.45 6.06 0.31 3.62e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1065656 0.563 rs391546 chr16:1915581 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.41 5.76 0.3 1.9e-8 Insulin-like growth factors; LUSC cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg13319975 chr6:146136371 FBXO30 0.49 7.32 0.37 1.88e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC trans rs9871760 0.956 rs2002913 chr3:126994823 A/G cg17872838 chr13:52607339 UTP14C 0.35 6.23 0.32 1.44e-9 Whole-brain volume; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25791773 chr11:129910324 NA -0.4 -6.13 -0.32 2.43e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs12286929 0.600 rs4445669 chr11:115045237 C/T cg04055981 chr11:115044050 NA -0.45 -8.27 -0.41 3.18e-15 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg17509989 chr5:176798049 RGS14 0.69 11.24 0.52 4.33e-25 Hemoglobin concentration;Hematocrit; LUSC cis rs2742417 0.603 rs1468542 chr3:45779136 A/T cg10512202 chr3:45649293 LIMD1 -0.36 -6.37 -0.33 6.35e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg13010199 chr12:38710504 ALG10B 0.64 10.02 0.48 7.68e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs73001065 0.591 rs57009615 chr19:19613622 A/G cg03709012 chr19:19516395 GATAD2A 1.04 10.4 0.49 3.93e-22 LDL cholesterol; LUSC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.08 -0.36 8.5e-12 Major depressive disorder; LUSC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg18827107 chr12:86230957 RASSF9 0.47 6.97 0.36 1.69e-11 Major depressive disorder; LUSC trans rs3733585 0.579 rs4235353 chr4:10122934 C/T cg26043149 chr18:55253948 FECH -0.52 -7.6 -0.38 3e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg21573476 chr21:45109991 RRP1B -0.38 -6.15 -0.32 2.25e-9 Mean corpuscular volume; LUSC cis rs7568458 1.000 rs7568458 chr2:85788175 T/A cg02493740 chr2:85810744 VAMP5 -0.36 -6.47 -0.33 3.41e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11711311 1.000 rs921741 chr3:113444051 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.82 0.35 4.2e-11 IgG glycosylation; LUSC cis rs12681287 0.547 rs13249177 chr8:87513034 A/G cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs1065852 0.861 rs5758627 chr22:42572547 C/T cg00645731 chr22:42541494 CYP2D7P1 0.57 9.73 0.47 7.06e-20 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs7202877 0.706 rs8046184 chr16:75411725 T/C cg04384234 chr16:75411784 CFDP1 -0.65 -9.05 -0.44 1.18e-17 Type 2 diabetes;Type 1 diabetes; LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg05064044 chr6:292385 DUSP22 -0.48 -6.7 -0.34 8.66e-11 Menopause (age at onset); LUSC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.22 -0.32 1.49e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7681440 0.560 rs67876224 chr4:90808918 T/C cg06632027 chr4:90757378 SNCA -0.37 -5.73 -0.3 2.26e-8 Dementia with Lewy bodies; LUSC cis rs9467773 0.620 rs2101582 chr6:26622734 C/T cg05738196 chr6:26577821 NA 0.77 14.74 0.63 3.02e-38 Intelligence (multi-trait analysis); LUSC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg21951975 chr1:209979733 IRF6 0.57 8.52 0.42 5.6e-16 Cleft lip with or without cleft palate; LUSC cis rs2486288 0.656 rs11639349 chr15:45568260 C/T cg04036182 chr15:45458818 NA -0.36 -5.78 -0.3 1.69e-8 Glomerular filtration rate; LUSC cis rs12711979 0.765 rs13030772 chr2:3821280 T/C cg17052675 chr2:3827356 NA -0.58 -11.38 -0.53 1.42e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs807669 0.903 rs1780642 chr22:19170604 T/C cg02655711 chr22:19163373 SLC25A1 0.9 17.93 0.7 7.5400000000000006e-51 Metabolite levels; LUSC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 9.41 0.46 8.26e-19 Hip circumference adjusted for BMI; LUSC cis rs6582630 0.599 rs12824838 chr12:38373584 G/T cg26384229 chr12:38710491 ALG10B -0.55 -8.34 -0.42 1.93e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs9650315 0.733 rs55853952 chr8:57204930 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs9467773 1.000 rs9467774 chr6:26505036 C/A cg05738196 chr6:26577821 NA 0.81 15.2 0.64 4.95e-40 Intelligence (multi-trait analysis); LUSC cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg10978503 chr1:24200527 CNR2 0.48 11.15 0.52 9.46e-25 Immature fraction of reticulocytes; LUSC cis rs9463078 0.764 rs3799968 chr6:44805377 C/T cg25276700 chr6:44698697 NA -0.3 -6.03 -0.31 4.36e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9796 0.621 rs537244 chr15:41469313 G/T cg18705301 chr15:41695430 NDUFAF1 0.48 8.53 0.42 5.24e-16 Menopause (age at onset); LUSC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg09359103 chr1:154839909 KCNN3 -0.74 -18.16 -0.7 9.16e-52 Prostate cancer; LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.28 6.17 0.32 1.94e-9 Electroencephalogram traits; LUSC cis rs2637266 1.000 rs2579749 chr10:78332105 T/C cg18941641 chr10:78392320 NA 0.37 6.58 0.34 1.83e-10 Pulmonary function; LUSC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.86 -0.35 3.32e-11 Total body bone mineral density; LUSC cis rs2853333 0.934 rs2519961 chr19:35751679 G/A cg12287945 chr19:35758300 LSR -0.37 -5.76 -0.3 1.96e-8 Red blood cell count; LUSC trans rs877282 0.853 rs7092805 chr10:756246 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.51 -0.34 2.72e-10 Uric acid levels; LUSC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg24110177 chr3:50126178 RBM5 -0.55 -9.05 -0.44 1.22e-17 Intelligence (multi-trait analysis); LUSC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg27398817 chr8:82754497 SNX16 -0.66 -8.42 -0.42 1.13e-15 Diastolic blood pressure; LUSC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg06618935 chr21:46677482 NA -0.39 -7.81 -0.39 7.65e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11758351 0.660 rs75156165 chr6:26235699 C/A cg01420254 chr6:26195488 NA 0.65 7.24 0.37 3.03e-12 Gout;Renal underexcretion gout; LUSC cis rs6541297 0.699 rs966333 chr1:230305477 T/C cg05784532 chr1:230284198 GALNT2 0.59 6.78 0.35 5.46e-11 Coronary artery disease; LUSC cis rs16870629 1.000 rs16870629 chr5:1015063 C/T cg00278107 chr5:1061253 SLC12A7 -0.64 -9.66 -0.47 1.29e-19 QT interval; LUSC cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg12935359 chr14:103987150 CKB -0.62 -9.96 -0.48 1.28e-20 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.534 rs1843733 chr12:34047626 T/C cg26384229 chr12:38710491 ALG10B 0.68 10.67 0.5 4.61e-23 Morning vs. evening chronotype; LUSC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg06634786 chr22:41940651 POLR3H -0.53 -6.12 -0.32 2.61e-9 Vitiligo; LUSC cis rs7923609 0.811 rs7919685 chr10:65315800 G/T cg01631684 chr10:65280961 REEP3 0.41 6.05 0.31 3.84e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg02773041 chr1:40204384 PPIE 0.54 8.26 0.41 3.35e-15 Blood protein levels; LUSC cis rs9486719 1.000 rs12208449 chr6:96903253 A/G cg06623918 chr6:96969491 KIAA0776 0.78 9.71 0.47 8.32e-20 Migraine;Coronary artery disease; LUSC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg14552801 chr7:65878734 NA 0.38 5.85 0.3 1.18e-8 Aortic root size; LUSC cis rs4595586 0.545 rs6580893 chr12:39371885 G/T cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.13e-8 Breast cancer; LUSC cis rs7904368 0.806 rs7900527 chr10:16857992 C/G cg14835575 chr10:16859367 RSU1 0.78 10.21 0.49 1.8e-21 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs9487051 0.799 rs830553 chr6:109550017 T/G cg01475377 chr6:109611718 NA -0.36 -5.93 -0.31 7.69e-9 Reticulocyte fraction of red cells; LUSC cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg23649088 chr2:200775458 C2orf69 -0.55 -6.98 -0.36 1.64e-11 Schizophrenia; LUSC trans rs9329221 0.698 rs35388602 chr8:10259188 T/C cg06636001 chr8:8085503 FLJ10661 0.49 6.73 0.35 7.2e-11 Neuroticism; LUSC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg27124370 chr19:33622961 WDR88 0.51 7.38 0.37 1.24e-12 Colorectal cancer; LUSC trans rs853679 1.000 rs853694 chr6:28279100 A/T cg06606381 chr12:133084897 FBRSL1 -0.56 -6.45 -0.33 3.88e-10 Depression; LUSC cis rs4906332 0.966 rs17679729 chr14:103924312 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.78e-12 Coronary artery disease; LUSC cis rs10203711 1.000 rs907107 chr2:239565780 T/C cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1670533 1.000 rs7660779 chr4:1075940 A/G cg02018176 chr4:1364513 KIAA1530 0.46 6.49 0.33 3.07e-10 Recombination rate (females); LUSC trans rs853679 0.546 rs34194357 chr6:27818535 A/G cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.13e-9 Depression; LUSC cis rs28595532 0.748 rs72670248 chr4:119335536 A/C cg21605333 chr4:119757512 SEC24D 1.02 8.3 0.41 2.57e-15 Cannabis dependence symptom count; LUSC cis rs752010 0.905 rs4525030 chr1:42091307 G/C cg06885757 chr1:42089581 HIVEP3 0.45 8.98 0.44 2.09e-17 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs11048434 0.661 rs34791180 chr12:9110919 T/C cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC cis rs7903847 0.620 rs11189165 chr10:99123457 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.22 -0.37 3.46e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg00814883 chr7:100076585 TSC22D4 -0.73 -9.72 -0.47 7.83e-20 Platelet count; LUSC cis rs68170813 0.559 rs6971774 chr7:106834139 A/G cg02696742 chr7:106810147 HBP1 -0.63 -9.88 -0.48 2.3e-20 Coronary artery disease; LUSC trans rs6502050 0.769 rs4789741 chr17:80119184 A/C cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.19e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg12432903 chr7:1882776 MAD1L1 0.53 6.79 0.35 5.03e-11 Bipolar disorder; LUSC cis rs9905704 0.756 rs302860 chr17:56695008 C/A cg12560992 chr17:57184187 TRIM37 0.58 8.38 0.42 1.49e-15 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg13206674 chr6:150067644 NUP43 0.6 9.5 0.46 4.2e-19 Lung cancer; LUSC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg08888203 chr3:10149979 C3orf24 0.45 6.83 0.35 4.08e-11 Alzheimer's disease; LUSC cis rs9457247 0.967 rs428805 chr6:167403132 C/A cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.8 -0.39 7.73e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg23283495 chr1:209979779 IRF6 0.67 7.92 0.4 3.5e-14 Coronary artery disease; LUSC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.34 -0.33 7.59e-10 Extrinsic epigenetic age acceleration; LUSC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7572644 0.665 rs4665393 chr2:28040276 G/A cg27432699 chr2:27873401 GPN1 0.57 7.28 0.37 2.47e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11630290 0.592 rs1039818 chr15:64155296 A/G cg12036633 chr15:63758958 NA 0.52 6.63 0.34 1.37e-10 Iris characteristics; LUSC cis rs7582720 0.832 rs116426890 chr2:204196618 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.73 6.88 0.35 2.92e-11 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7191439 0.858 rs8044367 chr16:88783374 A/G cg02389323 chr16:88786976 FAM38A 1.15 11.14 0.52 1.01e-24 Plateletcrit; LUSC trans rs11098499 0.954 rs6822679 chr4:120402702 A/C cg25214090 chr10:38739885 LOC399744 0.54 8.05 0.4 1.44e-14 Corneal astigmatism; LUSC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg22484793 chr3:52261325 TLR9 0.29 6.42 0.33 4.55e-10 Electroencephalogram traits; LUSC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg19318889 chr4:1322082 MAEA 0.55 9.04 0.44 1.26e-17 Longevity; LUSC cis rs3733631 1.000 rs1482582 chr4:104651553 A/C cg24090629 chr4:104641072 TACR3 -0.46 -5.76 -0.3 1.89e-8 Menarche (age at onset); LUSC cis rs12286929 0.637 rs34138164 chr11:115050127 A/G cg04055981 chr11:115044050 NA 0.43 7.85 0.39 5.79e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg08280861 chr8:58055591 NA 0.59 6.9 0.35 2.64e-11 Developmental language disorder (linguistic errors); LUSC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg00599273 chr12:58146742 CDK4 0.31 5.96 0.31 6.44e-9 Multiple sclerosis; LUSC cis rs10089 0.953 rs4835940 chr5:127406596 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 12.31 0.56 5.69e-29 Ileal carcinoids; LUSC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg24675658 chr1:53192096 ZYG11B 0.75 12.9 0.58 3.69e-31 Monocyte count; LUSC cis rs11864453 0.647 rs8043606 chr16:72135319 T/C cg16558253 chr16:72132732 DHX38 -0.38 -6.07 -0.32 3.45e-9 Fibrinogen levels; LUSC cis rs1775715 0.737 rs2778661 chr10:32159191 C/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.07 0.31 3.57e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9393777 0.623 rs9358946 chr6:26478927 G/A cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC cis rs3807375 1.000 rs3807375 chr7:150667210 C/T cg10636020 chr7:150656979 KCNH2 -0.3 -6.15 -0.32 2.17e-9 Electrocardiographic traits;QT interval; LUSC cis rs76419734 0.510 rs2544402 chr4:106687733 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.57 -6.64 -0.34 1.3e-10 Post bronchodilator FEV1; LUSC cis rs11585357 0.947 rs11584287 chr1:17607501 G/C cg08277548 chr1:17600880 PADI3 -0.69 -6.94 -0.36 1.99e-11 Hair shape; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05228964 chr6:170597377 DLL1 -0.48 -8.2 -0.41 5.13e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2235649 0.833 rs9925460 chr16:1849943 C/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -5.88 -0.31 9.73e-9 Blood metabolite levels; LUSC cis rs394563 0.591 rs237012 chr6:149729198 T/C cg11245181 chr6:149772854 ZC3H12D -0.29 -6.33 -0.33 7.91e-10 Dupuytren's disease; LUSC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg12463550 chr7:65579703 CRCP 0.65 5.92 0.31 7.98e-9 Diabetic kidney disease; LUSC cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg04034577 chr2:241836375 C2orf54 -0.47 -8.63 -0.43 2.47e-16 Urinary metabolites; LUSC trans rs637571 0.522 rs538954 chr11:65756808 A/G cg17712092 chr4:129076599 LARP1B 0.72 10.87 0.51 9.12e-24 Eosinophil percentage of white cells; LUSC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg18352616 chr4:3374830 RGS12 0.34 6.92 0.35 2.34e-11 Serum sulfate level; LUSC cis rs870825 0.616 rs6552808 chr4:185642865 G/T cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg07507251 chr3:52567010 NT5DC2 0.32 6.25 0.32 1.24e-9 Bipolar disorder; LUSC cis rs7927592 0.913 rs10896346 chr11:68352671 C/T cg20283391 chr11:68216788 NA -0.61 -8.42 -0.42 1.15e-15 Total body bone mineral density; LUSC cis rs71444571 1 rs71444571 chr12:123771015 G/A cg13010344 chr12:123464640 ARL6IP4 0.55 6.69 0.34 9.37e-11 Lymphocyte percentage of white cells; LUSC trans rs61931739 0.500 rs7310576 chr12:34474735 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.4 0.59 4.63e-33 Morning vs. evening chronotype; LUSC trans rs11700980 1.000 rs73898415 chr21:30125827 G/A cg05609335 chr17:75789393 NA 0.41 6.21 0.32 1.59e-9 QRS complex (12-leadsum); LUSC cis rs11676348 0.772 rs12694427 chr2:218945045 C/T cg00012203 chr2:219082015 ARPC2 -0.46 -7.02 -0.36 1.23e-11 Ulcerative colitis; LUSC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg25204440 chr1:209979598 IRF6 0.5 5.72 0.3 2.36e-8 Cleft lip with or without cleft palate; LUSC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg02788857 chr8:22132959 PIWIL2 0.39 7.42 0.38 9.77e-13 Hypertriglyceridemia; LUSC cis rs4988958 0.527 rs3771155 chr2:103037826 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.35e-12 Asthma (childhood onset); LUSC cis rs4776059 1.000 rs12914502 chr15:52911335 A/G cg22715398 chr15:52968154 KIAA1370 -0.67 -9.95 -0.48 1.38e-20 Schizophrenia; LUSC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.58 0.54 2.74e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.72 0.39 1.39e-13 Lung function (FEV1/FVC); LUSC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg19912559 chr1:40204330 PPIE 0.53 8.14 0.41 8.17e-15 Blood protein levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14597223 chr7:56119231 PSPH;CCT6A -0.41 -5.99 -0.31 5.52e-9 Hepatitis; LUSC cis rs9527 0.662 rs4919687 chr10:104595248 G/A cg23093090 chr10:104574429 C10orf26 -0.4 -6.8 -0.35 4.88e-11 Arsenic metabolism; LUSC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg19046167 chr17:80928561 B3GNTL1 0.5 7.08 0.36 8.79e-12 Glycated hemoglobin levels; LUSC cis rs9323205 0.773 rs11625621 chr14:51713659 G/C cg23942311 chr14:51606299 NA -0.41 -7.84 -0.39 6.13e-14 Cancer; LUSC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg25036284 chr2:26402008 FAM59B -0.68 -9.66 -0.47 1.21e-19 Gut microbiome composition (summer); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg17218495 chr19:11071743 SMARCA4 0.48 7.57 0.38 3.65e-13 Triglycerides; LUSC trans rs7937682 0.889 rs7948236 chr11:111499933 C/A cg18187862 chr3:45730750 SACM1L 0.56 7.07 0.36 9.38e-12 Primary sclerosing cholangitis; LUSC cis rs9486715 0.867 rs4839842 chr6:96955387 A/T cg06623918 chr6:96969491 KIAA0776 0.94 17.57 0.69 2.21e-49 Headache; LUSC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg08508325 chr11:3079039 CARS -0.51 -12.19 -0.55 1.65e-28 Longevity; LUSC cis rs17824933 0.943 rs2074230 chr11:60783804 C/T cg16817237 chr11:60793675 NA 0.4 6.44 0.33 4.04e-10 Multiple sclerosis; LUSC cis rs16866061 1.000 rs72974203 chr2:225408430 G/A cg12698349 chr2:225449008 CUL3 0.87 14.27 0.62 2.14e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs61931739 0.500 rs7963282 chr12:34535255 A/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC trans rs6502050 0.835 rs12051747 chr17:80114814 T/C cg07393940 chr7:158741817 NA 0.36 6.47 0.33 3.47e-10 Life satisfaction; LUSC cis rs55794721 0.509 rs6699896 chr1:25762902 A/T cg20684491 chr1:25596433 NA 0.38 6.03 0.31 4.28e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs9911578 0.967 rs6503890 chr17:57064167 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.92 0.35 2.36e-11 Intelligence (multi-trait analysis); LUSC cis rs782590 0.643 rs13032503 chr2:55739093 C/T cg18811423 chr2:55921094 PNPT1 -0.65 -9.19 -0.45 4.3e-18 Metabolic syndrome; LUSC cis rs9527 0.615 rs36045108 chr10:104697929 G/A cg23093090 chr10:104574429 C10orf26 -0.37 -6.79 -0.35 5.23e-11 Arsenic metabolism; LUSC cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg18964960 chr10:1102726 WDR37 -0.45 -6.13 -0.32 2.54e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs8060686 0.668 rs8046355 chr16:68205214 T/A cg09835421 chr16:68378352 PRMT7 -0.45 -5.71 -0.3 2.45e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg08807101 chr21:30365312 RNF160 0.7 11.11 0.52 1.25e-24 Selective IgA deficiency; LUSC cis rs7112043 0.868 rs10768093 chr11:34777559 T/C cg06937548 chr11:34938143 PDHX;APIP 0.4 5.75 0.3 2.03e-8 Lung disease severity in cystic fibrosis; LUSC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg20849893 chr7:64541193 NA -0.65 -5.7 -0.3 2.68e-8 Diabetic kidney disease; LUSC cis rs7726839 0.540 rs7434 chr5:660804 A/G cg16447950 chr5:562315 NA 0.55 7.02 0.36 1.22e-11 Obesity-related traits; LUSC cis rs3796619 1.000 rs11939380 chr4:1086871 C/T cg27284194 chr4:1044797 NA -0.49 -8.16 -0.41 6.69e-15 Recombination rate (males); LUSC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg03806693 chr22:41940476 POLR3H 0.88 12.29 0.56 7.03e-29 Vitiligo; LUSC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg20891283 chr12:69753455 YEATS4 0.81 14.38 0.62 8.18e-37 Blood protein levels; LUSC cis rs2742417 1.000 rs17328701 chr3:45734258 A/G cg09608765 chr3:45636137 LIMD1 -0.37 -7.23 -0.37 3.35e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg06238570 chr21:40685208 BRWD1 -0.63 -10.57 -0.5 1.01e-22 Cognitive function; LUSC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4718428 0.705 rs10267335 chr7:66403220 G/T cg12165864 chr7:66369176 NA -0.53 -7.07 -0.36 8.93e-12 Corneal structure; LUSC trans rs11098499 0.954 rs10031483 chr4:120422636 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg05855489 chr10:104503620 C10orf26 0.53 8.09 0.4 1.11e-14 Arsenic metabolism; LUSC cis rs12594515 0.967 rs11857628 chr15:45998206 C/T cg19682013 chr15:45996608 NA 0.38 5.74 0.3 2.12e-8 Waist circumference;Weight; LUSC trans rs11039798 1.000 rs11039978 chr11:48760237 A/G cg03929089 chr4:120376271 NA 0.74 6.91 0.35 2.4e-11 Axial length; LUSC cis rs1577917 0.958 rs13207173 chr6:86457522 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.77 -0.35 5.87e-11 Response to antipsychotic treatment; LUSC cis rs2219968 0.962 rs62508224 chr8:78941659 C/T cg00738934 chr8:78996279 NA 0.39 6.97 0.36 1.66e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg22823121 chr1:150693482 HORMAD1 0.55 7.96 0.4 2.65e-14 Melanoma; LUSC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg11812906 chr14:75593930 NEK9 0.67 11.39 0.53 1.31e-25 Height; LUSC trans rs67133203 0.799 rs12828536 chr12:51426035 C/T cg17484237 chr5:156536107 HAVCR2 0.44 5.97 0.31 6.2e-9 Urinary tract infection frequency; LUSC trans rs9951602 0.512 rs8089247 chr18:76651467 C/A cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.29e-32 Obesity-related traits; LUSC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg23281280 chr6:28129359 ZNF389 0.44 5.73 0.3 2.27e-8 Depression; LUSC cis rs17433780 0.897 rs12142922 chr1:89489915 A/G cg09516651 chr1:89888402 LOC400759 0.58 9.97 0.48 1.15e-20 Carotid intima media thickness; LUSC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg09165964 chr15:75287851 SCAMP5 -1.06 -16.3 -0.67 2.29e-44 Blood trace element (Zn levels); LUSC cis rs12594515 1.000 rs8027000 chr15:45987795 T/C cg19682013 chr15:45996608 NA 0.39 6.04 0.31 4.13e-9 Waist circumference;Weight; LUSC cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg19628046 chr18:33552617 C18orf21 0.52 6.14 0.32 2.28e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs56399783 0.901 rs79932907 chr7:2827901 C/G cg19731401 chr7:2775893 GNA12 0.68 9.34 0.46 1.39e-18 Childhood ear infection; LUSC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg22800045 chr5:56110881 MAP3K1 -0.4 -5.66 -0.3 3.21e-8 Coronary artery disease; LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.45 0.38 8.3e-13 Bipolar disorder; LUSC cis rs2273669 0.588 rs6568555 chr6:109331777 A/G cg05315195 chr6:109294784 ARMC2 -0.53 -5.89 -0.31 9.28e-9 Prostate cancer; LUSC cis rs56399783 0.901 rs17241904 chr7:2875574 C/T cg19731401 chr7:2775893 GNA12 0.69 9.31 0.45 1.8e-18 Childhood ear infection; LUSC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg21285383 chr16:89894308 SPIRE2 0.33 6.82 0.35 4.21e-11 Vitiligo; LUSC cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg07606381 chr6:8435919 SLC35B3 -0.72 -11.75 -0.54 6.6e-27 Motion sickness; LUSC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg03188948 chr7:1209495 NA 0.45 6.05 0.31 3.91e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg10295955 chr4:187884368 NA -1.04 -23.21 -0.79 1.25e-71 Lobe attachment (rater-scored or self-reported); LUSC cis rs1595825 0.891 rs78198610 chr2:198522769 T/C cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.34e-10 Ulcerative colitis; LUSC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2e-10 Reticulocyte fraction of red cells; LUSC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg03732007 chr1:2071316 PRKCZ 0.59 10.77 0.51 2.04e-23 Height; LUSC cis rs2637266 0.935 rs2583048 chr10:78404507 C/G cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.93e-13 Pulmonary function; LUSC cis rs738322 0.532 rs9622746 chr22:38564041 C/G cg25457927 chr22:38595422 NA -0.35 -6.67 -0.34 1.09e-10 Cutaneous nevi; LUSC cis rs1003719 0.715 rs9981715 chr21:38499610 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs11583043 1.000 rs6682873 chr1:101470906 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 6.07 0.32 3.52e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7589342 0.839 rs1465639 chr2:106439181 T/C cg16077055 chr2:106428750 NCK2 0.37 7.0 0.36 1.43e-11 Addiction; LUSC cis rs7202877 0.610 rs11646418 chr16:75367585 G/C cg03315344 chr16:75512273 CHST6 0.43 6.01 0.31 4.83e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs12594515 1.000 rs11070467 chr15:45985001 C/T cg01629716 chr15:45996671 NA -0.41 -6.1 -0.32 2.85e-9 Waist circumference;Weight; LUSC cis rs28735056 0.875 rs62103176 chr18:77623611 G/C cg20368463 chr18:77673604 PQLC1 0.48 6.74 0.35 7.01e-11 Schizophrenia; LUSC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg17385448 chr1:15911702 AGMAT 0.37 6.14 0.32 2.41e-9 Systolic blood pressure; LUSC cis rs11122272 0.735 rs2474625 chr1:231519331 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7208859 0.623 rs9915546 chr17:29132144 G/T cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs17767294 0.541 rs733743 chr6:28327371 C/G cg08851530 chr6:28072375 NA -0.93 -7.02 -0.36 1.23e-11 Parkinson's disease; LUSC cis rs2348418 0.715 rs11049720 chr12:28720410 A/G cg13890972 chr12:28721907 NA -0.39 -6.87 -0.35 3.24e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg13010199 chr12:38710504 ALG10B 0.7 10.77 0.51 1.97e-23 Bladder cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20481816 chr11:47448111 PSMC3 -0.47 -7.2 -0.37 4.06e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg05855489 chr10:104503620 C10orf26 0.58 9.34 0.46 1.41e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg22963979 chr7:1858916 MAD1L1 0.5 7.55 0.38 4.2e-13 Bipolar disorder and schizophrenia; LUSC cis rs7168353 1.000 rs7168353 chr15:93638401 C/G cg24217984 chr15:93633278 RGMA 0.35 5.94 0.31 6.97e-9 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs6687430 0.526 rs12127400 chr1:10613660 C/T cg17425144 chr1:10567563 PEX14 0.61 11.97 0.55 9.92e-28 Hand grip strength; LUSC cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg23158103 chr7:148848205 ZNF398 -0.47 -7.71 -0.39 1.5e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg14552801 chr7:65878734 NA -0.37 -5.87 -0.31 1.08e-8 Aortic root size; LUSC cis rs9638182 0.666 rs14415 chr7:72984780 T/C cg07452164 chr7:72993570 TBL2 0.46 6.5 0.34 2.95e-10 Triglycerides; LUSC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg07952391 chr2:88470173 THNSL2 0.76 6.71 0.34 8.5e-11 Plasma clusterin levels; LUSC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg20821713 chr7:1055600 C7orf50 -0.45 -6.22 -0.32 1.47e-9 Bronchopulmonary dysplasia; LUSC cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg09526685 chr4:187126073 CYP4V2 0.66 6.53 0.34 2.44e-10 Blood protein levels; LUSC cis rs7122539 0.506 rs10791896 chr11:66689240 G/T cg24851651 chr11:66362959 CCS 0.45 7.76 0.39 1.03e-13 HIV-1 susceptibility; LUSC cis rs367943 0.712 rs7731465 chr5:112687385 A/G cg12552261 chr5:112820674 MCC -0.38 -6.29 -0.33 9.9e-10 Type 2 diabetes; LUSC cis rs3741151 1.000 rs76610873 chr11:73084387 C/T cg17517138 chr11:73019481 ARHGEF17 1.0 8.46 0.42 8.69e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs804292 1.000 rs804292 chr8:11643915 C/T cg26752888 chr8:11627280 NEIL2 -1.0 -16.37 -0.67 1.21e-44 Alcohol dependence;Nicotine use; LUSC cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.75 0.51 2.47e-23 Hip circumference adjusted for BMI; LUSC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg13902645 chr11:5959945 NA -0.57 -7.89 -0.4 4.46e-14 DNA methylation (variation); LUSC cis rs13266463 0.830 rs6983790 chr8:143406575 A/G cg16886403 chr8:143471632 TSNARE1 0.62 8.94 0.44 2.76e-17 Schizophrenia; LUSC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg20933634 chr6:27740509 NA 0.4 5.87 0.31 1.06e-8 Parkinson's disease; LUSC cis rs6459804 0.844 rs76501205 chr7:157508941 A/T cg05731713 chr7:157510257 PTPRN2 0.49 9.42 0.46 7.82e-19 Bipolar disorder and schizophrenia; LUSC cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs11190604 1.000 rs10883504 chr10:102280687 G/A cg23241863 chr10:102295624 HIF1AN 0.48 5.73 0.3 2.29e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.36 0.42 1.69e-15 Tonsillectomy; LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg01879757 chr17:41196368 BRCA1 -0.47 -7.21 -0.37 3.83e-12 Menopause (age at onset); LUSC cis rs1982963 0.585 rs61971558 chr14:52496024 G/A cg10843707 chr14:52510701 NID2 0.46 6.29 0.33 1.01e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs477895 1.000 rs2286614 chr11:64068310 C/T cg23719950 chr11:63933701 MACROD1 -0.62 -7.41 -0.38 1.05e-12 Mean platelet volume; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.32 0.56 5.39e-29 Prudent dietary pattern; LUSC cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg27490568 chr2:178487706 NA 0.39 5.74 0.3 2.14e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18738857 chr19:3606974 TBXA2R 0.4 6.55 0.34 2.2e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg06600287 chr1:53387719 ECHDC2 -0.3 -5.9 -0.31 9.03e-9 Monocyte count; LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg13047869 chr3:10149882 C3orf24 0.58 8.28 0.41 3.07e-15 Alzheimer's disease; LUSC cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg01884057 chr2:25150051 NA -0.38 -8.63 -0.43 2.58e-16 Body mass index; LUSC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.76 -14.02 -0.61 1.9e-35 Age at first birth; LUSC cis rs6977660 0.714 rs10231980 chr7:19789383 C/G cg07541023 chr7:19748670 TWISTNB 0.7 7.92 0.4 3.55e-14 Thyroid stimulating hormone; LUSC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -11.86 -0.54 2.59e-27 Extrinsic epigenetic age acceleration; LUSC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.73 -13.32 -0.59 9.22e-33 Intelligence (multi-trait analysis); LUSC cis rs568617 1.000 rs687672 chr11:65649984 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.5 -5.99 -0.31 5.45e-9 Crohn's disease; LUSC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.59 0.34 1.74e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg25767906 chr1:53392781 SCP2 -0.5 -9.21 -0.45 3.66e-18 Monocyte count; LUSC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg04398451 chr17:18023971 MYO15A 0.47 7.48 0.38 6.71e-13 Total body bone mineral density; LUSC cis rs6840360 0.593 rs10222925 chr4:152690215 A/G cg22705602 chr4:152727874 NA -0.39 -8.52 -0.42 5.42e-16 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg08975724 chr8:8085496 FLJ10661 -0.5 -7.59 -0.38 3.29e-13 Mood instability; LUSC trans rs1814175 0.817 rs4405313 chr11:50013636 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs1559088 1.000 rs8106453 chr19:33557412 C/T cg17764715 chr19:33622953 WDR88 0.59 7.9 0.4 4.06e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1847202 0.517 rs13062803 chr3:72951840 T/A cg25664220 chr3:72788482 NA -0.43 -7.76 -0.39 1.07e-13 Motion sickness; LUSC cis rs3845702 0.736 rs6433821 chr2:180837806 T/A cg01881094 chr2:180872142 CWC22 -1.06 -12.75 -0.57 1.28e-30 Schizophrenia; LUSC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg11608241 chr8:8085544 FLJ10661 0.44 6.68 0.34 1.01e-10 Systolic blood pressure; LUSC cis rs9646944 0.501 rs12712144 chr2:102995600 C/G cg20060108 chr2:102954350 IL1RL1 0.47 6.32 0.33 8.2e-10 Blood protein levels; LUSC cis rs936229 0.813 rs2301249 chr15:75092384 T/C cg14664628 chr15:75095509 CSK -1.01 -17.86 -0.7 1.48e-50 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -6.05 -0.31 3.94e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.52 -6.87 -0.35 3.16e-11 Renal function-related traits (BUN); LUSC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg06637938 chr14:75390232 RPS6KL1 0.49 7.57 0.38 3.61e-13 Height; LUSC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg18904891 chr8:8559673 CLDN23 0.38 5.77 0.3 1.8e-8 Mood instability; LUSC cis rs5769707 0.656 rs135875 chr22:50012419 T/G cg05373962 chr22:49881684 NA -0.41 -8.5 -0.42 6.28e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.56 7.86 0.39 5.49e-14 Gut microbiome composition (summer); LUSC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg17971929 chr21:40555470 PSMG1 -0.62 -10.27 -0.49 1.06e-21 Cognitive function; LUSC cis rs228769 0.673 rs375677 chr17:42108974 A/C cg19774624 chr17:42201019 HDAC5 0.62 7.76 0.39 1.02e-13 Bone mineral density (hip);Bone mineral density (spine); LUSC trans rs61931739 0.534 rs11053005 chr12:34091626 A/C cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.37 0.42 1.61e-15 High light scatter reticulocyte count; LUSC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg02753203 chr1:228287806 NA 0.69 12.31 0.56 5.48e-29 Diastolic blood pressure; LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.95 0.31 6.72e-9 Menopause (age at onset); LUSC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.14e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs12210905 0.925 rs11961179 chr6:26994157 C/G cg11837749 chr1:55047332 ACOT11 0.57 6.13 0.32 2.51e-9 Hip circumference adjusted for BMI; LUSC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg04352962 chr1:209979756 IRF6 0.54 5.76 0.3 1.88e-8 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01614598 chr2:38152364 FAM82A1 0.42 6.12 0.32 2.6e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.59 8.62 0.43 2.68e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2286885 0.965 rs10987301 chr9:129250688 T/C cg15282417 chr9:129245246 FAM125B -0.37 -6.15 -0.32 2.25e-9 Intraocular pressure; LUSC cis rs1371867 0.775 rs6511 chr8:101252680 T/C cg06002616 chr8:101225028 SPAG1 0.42 6.99 0.36 1.48e-11 Atrioventricular conduction; LUSC cis rs9467773 0.620 rs2494692 chr6:26615223 G/A cg09904177 chr6:26538194 HMGN4 0.66 11.93 0.55 1.38e-27 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg05425664 chr17:57184151 TRIM37 0.52 7.68 0.39 1.75e-13 Intelligence (multi-trait analysis); LUSC cis rs9560113 0.508 rs2774425 chr13:112235077 A/G cg10483660 chr13:112241077 NA -0.38 -7.05 -0.36 1.04e-11 Menarche (age at onset); LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg22535103 chr8:58192502 C8orf71 -0.78 -7.97 -0.4 2.62e-14 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg02018176 chr4:1364513 KIAA1530 0.54 9.18 0.45 4.49e-18 Obesity-related traits; LUSC cis rs709400 0.663 rs3783402 chr14:103967929 C/G cg10523860 chr14:103875565 MARK3 -0.36 -5.73 -0.3 2.2e-8 Body mass index; LUSC trans rs1728785 0.901 rs3087783 chr16:68599668 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.38 0.42 1.46e-15 Ulcerative colitis; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.56 0.65 1.98e-41 Platelet count; LUSC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg06363034 chr20:62225388 GMEB2 -0.45 -7.71 -0.39 1.47e-13 Glioblastoma; LUSC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg23093090 chr10:104574429 C10orf26 -0.39 -7.44 -0.38 8.66e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19048535 chr5:89770306 MBLAC2;POLR3G -0.42 -6.2 -0.32 1.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11098499 0.954 rs6846442 chr4:120326323 G/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg11766577 chr21:47581405 C21orf56 0.41 5.9 0.31 8.81e-9 Testicular germ cell tumor; LUSC cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 6.72 0.35 7.7e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs7829975 0.711 rs4481596 chr8:8704330 G/C cg21775007 chr8:11205619 TDH 0.52 7.66 0.39 2e-13 Mood instability; LUSC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg13683864 chr3:40499215 RPL14 0.9 15.13 0.64 9.27e-40 Renal cell carcinoma; LUSC cis rs9309711 0.922 rs13385119 chr2:3484521 G/A cg10845886 chr2:3471009 TTC15 -0.61 -7.83 -0.39 6.35e-14 Neurofibrillary tangles; LUSC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.01 0.31 4.93e-9 Personality dimensions; LUSC cis rs10193935 0.901 rs12620021 chr2:42477034 T/C cg27598129 chr2:42591480 NA -0.62 -8.34 -0.42 1.98e-15 Colonoscopy-negative controls vs population controls; LUSC trans rs208520 1.000 rs12191403 chr6:66978137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.56 -8.52 -0.42 5.47e-16 Total body bone mineral density; LUSC cis rs1941023 0.584 rs4938941 chr11:60173360 C/T cg08716584 chr11:60157161 MS4A7 0.62 11.57 0.53 2.84e-26 Congenital heart disease (maternal effect); LUSC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC trans rs2204008 0.837 rs12146734 chr12:38237079 A/G cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.38e-9 Bladder cancer; LUSC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg03388025 chr16:89894329 SPIRE2 0.34 7.05 0.36 1.03e-11 Vitiligo; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14907986 chr6:24645932 KIAA0319 0.38 5.97 0.31 6.21e-9 Triglycerides; LUSC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg21665744 chr7:39171113 POU6F2 0.45 7.33 0.37 1.79e-12 IgG glycosylation; LUSC cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg06740227 chr12:86229804 RASSF9 0.45 7.15 0.36 5.35e-12 Major depressive disorder; LUSC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg22823121 chr1:150693482 HORMAD1 0.6 9.37 0.46 1.11e-18 Tonsillectomy; LUSC cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg05985134 chr18:33552581 C18orf21 0.51 6.87 0.35 3.19e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7647973 1.000 rs6785045 chr3:49435243 G/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.46 -6.99 -0.36 1.53e-11 Menarche (age at onset); LUSC cis rs6500395 1.000 rs924476 chr16:48556847 C/T cg04672837 chr16:48644449 N4BP1 0.46 6.73 0.35 7.23e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs611744 0.658 rs2443775 chr8:109062481 A/G cg18478394 chr8:109455254 TTC35 -0.43 -6.26 -0.32 1.2e-9 Dupuytren's disease; LUSC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg04166393 chr7:2884313 GNA12 -0.46 -6.36 -0.33 6.71e-10 Height; LUSC cis rs11992162 0.636 rs13265816 chr8:11797485 G/A cg21775007 chr8:11205619 TDH 0.44 5.95 0.31 6.71e-9 Monocyte count; LUSC cis rs708547 1.000 rs2412770 chr4:57794660 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -5.88 -0.31 9.93e-9 Response to bleomycin (chromatid breaks); LUSC cis rs2219968 0.926 rs13258410 chr8:78924203 T/C cg00738934 chr8:78996279 NA 0.39 6.98 0.36 1.58e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2985334 0.558 rs204063 chr1:29196466 T/G cg05928980 chr1:29567425 PTPRU 0.3 5.67 0.3 3.16e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6840360 0.571 rs1822347 chr4:152525319 A/G cg22705602 chr4:152727874 NA -0.33 -6.71 -0.34 8.54e-11 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.966 rs7270835 chr20:25435067 C/T cg03522245 chr20:25566470 NINL 0.35 5.66 0.3 3.26e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs240764 0.621 rs4840154 chr6:101225723 A/C cg09795085 chr6:101329169 ASCC3 -0.45 -6.34 -0.33 7.38e-10 Neuroticism; LUSC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26898955 chr1:84945537 RPF1 -0.43 -6.0 -0.31 5.27e-9 Hepatitis; LUSC cis rs1697139 0.583 rs6895853 chr5:66541427 T/C cg11553311 chr5:66541588 NA 0.34 6.33 0.33 7.87e-10 Breast cancer; LUSC trans rs6089829 0.925 rs6122087 chr20:61664553 T/C cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs10506458 0.688 rs73127095 chr12:63418283 T/G cg22491629 chr6:157744540 C6orf35 -0.61 -7.52 -0.38 5.14e-13 Hemostatic factors and hematological phenotypes; LUSC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg16049864 chr8:95962084 TP53INP1 -0.56 -10.24 -0.49 1.39e-21 Type 2 diabetes; LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.98 0.66 4.1e-43 Platelet count; LUSC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.76 11.39 0.53 1.28e-25 Cognitive test performance; LUSC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.05e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg16629158 chr2:122042988 TFCP2L1 0.37 5.97 0.31 5.99e-9 Mosquito bite size; LUSC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs6977660 0.714 rs12333747 chr7:19814394 G/A cg07541023 chr7:19748670 TWISTNB 0.66 7.21 0.37 3.71e-12 Thyroid stimulating hormone; LUSC cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg05985134 chr18:33552581 C18orf21 0.53 7.18 0.37 4.43e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg10862848 chr6:42927986 GNMT -0.28 -6.67 -0.34 1.08e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs983392 0.680 rs7929589 chr11:59975078 C/T cg24026212 chr11:59952134 MS4A6A -0.36 -6.23 -0.32 1.4e-9 Alzheimer's disease (late onset); LUSC cis rs6690583 0.623 rs6672362 chr1:85454881 C/G cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.02e-10 Serum sulfate level; LUSC trans rs28735056 0.967 rs11662248 chr18:77619009 C/T cg03973167 chr4:185394988 IRF2 0.44 6.14 0.32 2.28e-9 Schizophrenia; LUSC trans rs877282 0.945 rs10904556 chr10:789429 A/G cg13042288 chr15:90349979 ANPEP -0.46 -6.6 -0.34 1.63e-10 Uric acid levels; LUSC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg11764359 chr7:65958608 NA -0.8 -13.21 -0.59 2.42e-32 Aortic root size; LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 16.09 0.66 1.53e-43 Platelet count; LUSC trans rs17685 0.816 rs11763076 chr7:75765963 C/T cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg13683864 chr3:40499215 RPL14 -1.11 -21.4 -0.76 1.4e-64 Renal cell carcinoma; LUSC cis rs17604090 0.557 rs10279965 chr7:29717082 C/G cg19413766 chr7:29689036 LOC646762 -0.55 -7.46 -0.38 7.46e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07208908 chr17:79818639 P4HB -0.46 -6.04 -0.31 4.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg07362569 chr17:61921086 SMARCD2 0.38 7.68 0.39 1.82e-13 Prudent dietary pattern; LUSC cis rs10744422 0.925 rs3825143 chr12:123352179 C/T cg25930673 chr12:123319894 HIP1R -0.6 -6.1 -0.32 2.93e-9 Schizophrenia; LUSC cis rs6977660 1.000 rs6943114 chr7:19818354 G/T cg07541023 chr7:19748670 TWISTNB 0.5 5.74 0.3 2.18e-8 Thyroid stimulating hormone; LUSC cis rs1957429 0.520 rs72625646 chr14:65343809 C/A cg23373153 chr14:65346875 NA -0.9 -7.84 -0.39 5.92e-14 Pediatric areal bone mineral density (radius); LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg19747945 chr6:42946146 PEX6 -0.35 -5.88 -0.31 9.99e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9341808 0.754 rs6907729 chr6:81004922 A/T cg08355045 chr6:80787529 NA -0.55 -9.75 -0.47 6.35e-20 Sitting height ratio; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.0 21.98 0.77 7.08e-67 Prudent dietary pattern; LUSC cis rs250677 0.522 rs10477400 chr5:148359598 T/C cg18129178 chr5:148520854 ABLIM3 0.52 7.36 0.37 1.48e-12 Breast cancer; LUSC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg03351412 chr1:154909251 PMVK 0.47 7.21 0.37 3.74e-12 Prostate cancer; LUSC cis rs193541 0.632 rs62377425 chr5:122332625 C/G cg19077854 chr5:122220652 SNX24 -0.39 -8.07 -0.4 1.3e-14 Glucose homeostasis traits; LUSC cis rs12681288 0.550 rs58295701 chr8:962136 T/C cg15309053 chr8:964076 NA 0.4 7.97 0.4 2.55e-14 Schizophrenia; LUSC cis rs9788682 0.747 rs11637630 chr15:78899719 G/A cg24631222 chr15:78858424 CHRNA5 -0.7 -9.51 -0.46 3.96e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg19318889 chr4:1322082 MAEA -0.54 -8.76 -0.43 1.02e-16 Obesity-related traits; LUSC cis rs644799 0.542 rs10831416 chr11:95467220 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.64 9.71 0.47 8.77e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs897080 0.515 rs698795 chr2:44689326 C/A cg00619915 chr2:44497795 NA -0.44 -6.05 -0.31 3.98e-9 Height; LUSC cis rs6430585 0.527 rs76622824 chr2:136411879 A/G cg07169764 chr2:136633963 MCM6 1.04 13.97 0.61 3.08e-35 Corneal structure; LUSC cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.61 -0.57 4.37e-30 Chronic sinus infection; LUSC cis rs760805 1.000 rs11249204 chr1:25261740 C/T cg22509179 chr1:25234806 RUNX3 0.6 10.06 0.48 5.85e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg03433033 chr1:76189801 ACADM 0.75 10.76 0.51 2.17e-23 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs877282 0.947 rs7923867 chr10:768094 G/A cg13042288 chr15:90349979 ANPEP -0.49 -7.08 -0.36 8.35e-12 Uric acid levels; LUSC cis rs4660531 1.000 rs4660531 chr1:41839822 G/T cg08462924 chr1:41848221 NA 0.45 6.76 0.35 6.19e-11 Bipolar disorder; LUSC cis rs9399401 0.626 rs9373347 chr6:142779885 C/T cg03128060 chr6:142623767 GPR126 0.51 8.74 0.43 1.12e-16 Chronic obstructive pulmonary disease; LUSC cis rs912057 0.797 rs1294430 chr6:6744698 A/G cg06612196 chr6:6737390 NA 0.55 10.47 0.5 2.33e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs7927592 0.546 rs554734 chr11:68192518 T/G cg16797656 chr11:68205561 LRP5 0.45 7.76 0.39 1.02e-13 Total body bone mineral density; LUSC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg25566285 chr7:158114605 PTPRN2 0.31 5.69 0.3 2.84e-8 Calcium levels; LUSC cis rs6938 0.618 rs62029167 chr15:75228350 G/A cg14664628 chr15:75095509 CSK -0.52 -7.8 -0.39 7.81e-14 Breast cancer; LUSC cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.53 -7.91 -0.4 3.94e-14 Colorectal cancer; LUSC cis rs11247915 0.501 rs34209692 chr1:26608782 C/T cg15628303 chr1:26608928 UBXN11 0.49 8.0 0.4 2.01e-14 Obesity-related traits; LUSC cis rs3796619 0.961 rs11732520 chr4:1074009 C/T cg27284194 chr4:1044797 NA 0.48 7.84 0.39 6.24e-14 Recombination rate (males); LUSC cis rs7119 0.717 rs11636412 chr15:77767291 C/T cg27398640 chr15:77910606 LINGO1 -0.29 -5.85 -0.3 1.17e-8 Type 2 diabetes; LUSC cis rs3820928 1.000 rs2396433 chr2:227772502 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.85 -0.39 5.89e-14 Pulmonary function; LUSC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.89 -0.31 9.56e-9 Tonsillectomy; LUSC cis rs2274273 0.516 rs10136972 chr14:55370285 A/G cg04306507 chr14:55594613 LGALS3 0.32 6.0 0.31 5.19e-9 Protein biomarker; LUSC cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC trans rs6582630 0.519 rs12819814 chr12:38332568 G/C cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.08e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20564458 chr20:33999865 UQCC -0.45 -6.68 -0.34 9.94e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs12153263 0.504 rs4866177 chr5:20274081 A/G cg07262001 chr22:42734088 NA 0.32 5.95 0.31 6.64e-9 Obstetric antiphospholipid syndrome; LUSC cis rs57590327 0.503 rs12497231 chr3:81519291 A/G cg07356753 chr3:81810745 GBE1 0.45 6.02 0.31 4.68e-9 Extraversion; LUSC cis rs2130392 1.000 rs11132254 chr4:185611592 G/T cg21366198 chr4:185655624 MLF1IP -0.42 -5.87 -0.31 1.05e-8 Kawasaki disease; LUSC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 5.74 0.3 2.13e-8 Aortic root size; LUSC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs28735056 0.596 rs3744879 chr18:77679006 G/C cg05926928 chr17:57297772 GDPD1 -0.46 -6.43 -0.33 4.49e-10 Schizophrenia; LUSC cis rs208520 0.545 rs6899712 chr6:66749670 T/C cg07460842 chr6:66804631 NA 1.15 21.64 0.76 1.53e-65 Exhaled nitric oxide output; LUSC cis rs76878669 0.515 rs947978 chr11:66108660 C/T cg24851651 chr11:66362959 CCS -0.37 -5.92 -0.31 8.01e-9 Educational attainment (years of education); LUSC cis rs642803 1.000 rs642803 chr11:65560620 C/T cg27068330 chr11:65405492 SIPA1 0.54 7.6 0.38 2.95e-13 Urate levels; LUSC cis rs908922 0.924 rs6669608 chr1:152475233 A/G cg20991723 chr1:152506922 NA 0.5 8.1 0.41 1.07e-14 Hair morphology; LUSC cis rs12586317 0.883 rs4982254 chr14:35755737 C/T cg16230307 chr14:35515116 FAM177A1 0.6 7.37 0.37 1.37e-12 Psoriasis; LUSC cis rs7572733 0.534 rs700687 chr2:198721560 A/T cg00792783 chr2:198669748 PLCL1 0.43 5.86 0.31 1.12e-8 Dermatomyositis; LUSC cis rs6484504 0.817 rs67707190 chr11:31210500 A/G cg14844989 chr11:31128820 NA -0.47 -6.74 -0.35 7.15e-11 Red blood cell count; LUSC cis rs9527 0.545 rs10883847 chr10:104958284 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.81 0.47 3.95e-20 Arsenic metabolism; LUSC cis rs34638657 0.518 rs7196560 chr16:82168162 A/T cg09439754 chr16:82129088 HSD17B2 -0.32 -5.88 -0.31 9.86e-9 Lung adenocarcinoma; LUSC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg26566898 chr11:117069891 TAGLN 0.31 5.85 0.3 1.16e-8 Blood protein levels; LUSC cis rs250677 0.687 rs2915809 chr5:148452111 A/T cg18129178 chr5:148520854 ABLIM3 -0.7 -10.7 -0.51 3.48e-23 Breast cancer; LUSC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg00409905 chr10:38381863 ZNF37A -0.38 -6.38 -0.33 5.89e-10 Extrinsic epigenetic age acceleration; LUSC cis rs981844 0.775 rs62323976 chr4:154739032 A/G cg14289246 chr4:154710475 SFRP2 0.46 6.25 0.32 1.23e-9 Response to statins (LDL cholesterol change); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14913181 chr1:6845123 CAMTA1 0.44 6.57 0.34 1.88e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg18132916 chr6:79620363 NA -0.38 -5.69 -0.3 2.82e-8 Intelligence (multi-trait analysis); LUSC cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg04586622 chr2:25135609 ADCY3 0.42 8.99 0.44 1.88e-17 Body mass index; LUSC cis rs4842666 0.915 rs11105376 chr12:90088768 G/A cg00757033 chr12:89920650 WDR51B 0.46 6.44 0.33 4.26e-10 Blood pressure; LUSC cis rs977987 0.806 rs35787595 chr16:75466847 G/C cg03315344 chr16:75512273 CHST6 0.5 9.52 0.46 3.5e-19 Dupuytren's disease; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg14893161 chr1:205819251 PM20D1 0.94 18.91 0.72 1.02e-54 Menarche (age at onset); LUSC cis rs7107174 1.000 rs2510045 chr11:77920563 G/T cg02023728 chr11:77925099 USP35 0.52 7.1 0.36 7.33e-12 Testicular germ cell tumor; LUSC cis rs7618501 1.000 rs3749240 chr3:49750188 T/A cg12257692 chr3:49977190 RBM6 -0.21 -5.83 -0.3 1.31e-8 Intelligence (multi-trait analysis); LUSC cis rs10416265 0.528 rs28654374 chr19:33613610 G/A cg17764715 chr19:33622953 WDR88 0.6 6.37 0.33 6.44e-10 Bone properties (heel); LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg13560548 chr3:10150139 C3orf24 0.53 7.55 0.38 4.1e-13 Alzheimer's disease; LUSC cis rs7267979 0.528 rs2387976 chr20:25599560 C/T cg03522245 chr20:25566470 NINL -0.4 -6.12 -0.32 2.59e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.73 0.63 3.45e-38 Platelet count; LUSC cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg13319975 chr6:146136371 FBXO30 0.5 7.44 0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg06238570 chr21:40685208 BRWD1 -0.58 -8.82 -0.43 6.44e-17 Menarche (age at onset); LUSC cis rs12210905 0.925 rs72838262 chr6:27008517 G/C cg23155468 chr6:27110703 HIST1H2BK -0.69 -5.96 -0.31 6.58e-9 Hip circumference adjusted for BMI; LUSC cis rs12579753 1.000 rs11115015 chr12:82174543 T/C cg07988820 chr12:82153109 PPFIA2 -0.44 -6.2 -0.32 1.7e-9 Resting heart rate; LUSC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg25358565 chr5:93447407 FAM172A -0.89 -11.39 -0.53 1.27e-25 Diabetic retinopathy; LUSC cis rs11122272 0.766 rs2808614 chr1:231550168 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.7 11.03 0.52 2.5e-24 Hemoglobin concentration; LUSC cis rs6076065 0.748 rs2180139 chr20:23405281 G/A cg11657817 chr20:23433608 CST11 0.52 10.38 0.49 4.59e-22 Facial morphology (factor 15, philtrum width); LUSC cis rs72781680 0.678 rs2551341 chr2:24014778 G/T cg08917208 chr2:24149416 ATAD2B 0.6 6.91 0.35 2.44e-11 Lymphocyte counts; LUSC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.84 13.04 0.58 1.09e-31 Cognitive test performance; LUSC cis rs881375 0.967 rs2109895 chr9:123677827 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.96 0.31 6.33e-9 Rheumatoid arthritis; LUSC cis rs9399135 0.967 rs9389256 chr6:135331254 A/C cg24558204 chr6:135376177 HBS1L 0.59 9.2 0.45 3.94e-18 Red blood cell count; LUSC cis rs1385374 0.858 rs10847692 chr12:129289679 A/T cg09035930 chr12:129282057 SLC15A4 -0.64 -6.78 -0.35 5.5e-11 Systemic lupus erythematosus; LUSC cis rs2019216 0.524 rs1518049 chr17:21922055 C/T cg22648282 chr17:21454238 C17orf51 -0.49 -7.28 -0.37 2.48e-12 Pelvic organ prolapse; LUSC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg17749961 chr2:30669863 LCLAT1 0.69 7.93 0.4 3.4e-14 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg09877947 chr5:131593287 PDLIM4 0.48 7.93 0.4 3.33e-14 Breast cancer; LUSC cis rs62400317 0.556 rs10948196 chr6:44959384 A/T cg18551225 chr6:44695536 NA -0.35 -6.01 -0.31 4.81e-9 Total body bone mineral density; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.55 -8.0 -0.4 2.05e-14 Alzheimer's disease (late onset); LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03352830 chr11:487213 PTDSS2 0.76 9.12 0.45 7.41e-18 Body mass index; LUSC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg05802129 chr4:122689817 NA 0.36 6.52 0.34 2.6e-10 Type 2 diabetes; LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg04287289 chr16:89883240 FANCA -0.77 -13.46 -0.59 2.72e-33 Vitiligo; LUSC cis rs2749592 0.531 rs1208559 chr10:38221370 T/C cg00409905 chr10:38381863 ZNF37A 0.35 5.81 0.3 1.42e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03576123 chr11:487126 PTDSS2 0.94 10.37 0.49 4.88e-22 Body mass index; LUSC cis rs3815700 1.000 rs7248273 chr19:33096816 C/T cg02997394 chr19:33096574 ANKRD27 0.81 8.46 0.42 8.62e-16 Eosinophilic esophagitis; LUSC cis rs9457247 1.000 rs239935 chr6:167411788 G/A cg07741184 chr6:167504864 NA 0.41 7.26 0.37 2.72e-12 Crohn's disease; LUSC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg14343924 chr8:8086146 FLJ10661 0.4 5.7 0.3 2.69e-8 Mood instability; LUSC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg11247378 chr22:39784982 NA 0.62 10.92 0.51 6.12e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs3020736 0.500 rs4147638 chr22:42487900 G/A cg15557168 chr22:42548783 NA 0.48 7.39 0.38 1.16e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.22 0.32 1.47e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg08999081 chr20:33150536 PIGU -0.51 -10.3 -0.49 9.03e-22 Glomerular filtration rate (creatinine); LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg14159672 chr1:205819179 PM20D1 0.82 14.69 0.63 4.76e-38 Menarche (age at onset); LUSC cis rs1003719 0.725 rs2187101 chr21:38452379 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.71 11.67 0.54 1.31e-26 Eye color traits; LUSC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.93 14.88 0.63 9.31e-39 Multiple sclerosis; LUSC cis rs4853012 0.887 rs7570950 chr2:74338942 T/C cg20891558 chr2:74357851 NA 0.75 12.5 0.56 1.15e-29 Gestational age at birth (maternal effect); LUSC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg05234568 chr11:5960015 NA -0.6 -8.57 -0.42 3.84e-16 DNA methylation (variation); LUSC trans rs57221529 0.766 rs12518859 chr5:587432 C/T cg25482853 chr8:67687455 SGK3 1.18 16.97 0.68 5.1e-47 Lung disease severity in cystic fibrosis; LUSC cis rs79976124 0.879 rs10944856 chr6:66636960 G/C cg07460842 chr6:66804631 NA 0.71 8.87 0.44 4.61e-17 Type 2 diabetes; LUSC cis rs709400 0.663 rs62007719 chr14:103943130 G/T cg12935359 chr14:103987150 CKB -0.54 -8.41 -0.42 1.18e-15 Body mass index; LUSC cis rs17270561 0.609 rs12203927 chr6:25732690 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs72781680 0.898 rs72786276 chr2:24062566 G/A cg08917208 chr2:24149416 ATAD2B 0.96 10.07 0.48 5.08e-21 Lymphocyte counts; LUSC trans rs11165623 0.792 rs1125358 chr1:96971800 T/C cg10631902 chr5:14652156 NA -0.48 -7.37 -0.37 1.37e-12 Hip circumference;Waist circumference; LUSC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.15 0.55 2.19e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg00684032 chr4:1343700 KIAA1530 0.38 6.6 0.34 1.63e-10 Obesity-related traits; LUSC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg22857025 chr5:266934 NA 1.05 14.65 0.63 7.17e-38 Breast cancer; LUSC cis rs2410601 0.520 rs1426916 chr8:18882501 C/G cg19414122 chr8:18896631 NA 0.29 5.81 0.3 1.48e-8 Urinary albumin excretion rate in type 1 diabetes; LUSC cis rs9807989 0.801 rs10176664 chr2:102976172 G/A cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs7267979 1.000 rs4813566 chr20:25386465 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12760731 0.623 rs721289 chr1:178395682 A/G cg00404053 chr1:178313656 RASAL2 0.47 5.67 0.3 3.15e-8 Obesity-related traits; LUSC cis rs9549367 0.636 rs486407 chr13:113833499 G/A cg18105134 chr13:113819100 PROZ 0.66 9.91 0.48 1.79e-20 Platelet distribution width; LUSC cis rs950776 0.684 rs61012457 chr15:78865694 C/G cg06917634 chr15:78832804 PSMA4 0.72 11.47 0.53 6.95e-26 Sudden cardiac arrest; LUSC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg25767906 chr1:53392781 SCP2 -0.34 -5.96 -0.31 6.46e-9 Monocyte count; LUSC trans rs72674100 1.000 rs112113294 chr4:97967853 G/T cg09670535 chr1:18959427 PAX7 -0.64 -6.12 -0.32 2.68e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg03517284 chr6:25882590 NA -0.45 -7.46 -0.38 7.37e-13 Intelligence (multi-trait analysis); LUSC cis rs4911259 0.552 rs13042651 chr20:31467423 C/T cg13636640 chr20:31349939 DNMT3B -0.81 -15.75 -0.65 3.4e-42 Inflammatory bowel disease; LUSC cis rs7937682 0.632 rs11214009 chr11:111683142 T/C cg09085632 chr11:111637200 PPP2R1B 0.93 12.48 0.56 1.29e-29 Primary sclerosing cholangitis; LUSC cis rs77633900 0.772 rs157788 chr15:76806011 T/C cg21673338 chr15:77095150 SCAPER -0.71 -6.12 -0.32 2.65e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs735396 1.000 rs1169306 chr12:121438311 C/T cg02403541 chr12:121454288 C12orf43 0.59 8.24 0.41 3.99e-15 N-glycan levels; LUSC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg09849774 chr21:43526787 UMODL1;C21orf128 -0.42 -6.14 -0.32 2.4e-9 IgG glycosylation; LUSC cis rs2932538 0.614 rs6537741 chr1:113085175 A/C cg22162597 chr1:113214053 CAPZA1 -0.63 -7.79 -0.39 8.4e-14 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs9660992 0.508 rs113817010 chr1:205104581 C/A cg03948781 chr1:205179583 DSTYK 0.32 6.18 0.32 1.84e-9 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10752881 0.875 rs10752894 chr1:183050610 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Colorectal cancer; LUSC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg06219351 chr7:158114137 PTPRN2 -0.52 -9.51 -0.46 3.88e-19 Calcium levels; LUSC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg14019146 chr3:50243930 SLC38A3 -0.32 -7.13 -0.36 6.11e-12 Intelligence (multi-trait analysis); LUSC trans rs8073060 0.586 rs72829922 chr17:34044809 G/A cg19694781 chr19:47549865 TMEM160 1.14 18.04 0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs12249377 0.519 rs35987367 chr10:92591992 C/T cg14313238 chr10:92632228 RPP30 0.42 5.79 0.3 1.62e-8 White matter microstructure (global fractional anisotropy); LUSC cis rs778371 0.874 rs1083522 chr2:233745521 C/T cg08000102 chr2:233561755 GIGYF2 -0.74 -11.17 -0.52 8.13e-25 Schizophrenia; LUSC cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg23711669 chr6:146136114 FBXO30 0.87 16.35 0.67 1.49e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg05985134 chr18:33552581 C18orf21 0.51 6.92 0.35 2.35e-11 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs75804782 0.641 rs55844289 chr2:239323207 C/T cg01134436 chr17:81009848 B3GNTL1 0.65 6.42 0.33 4.55e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg10802521 chr3:52805072 NEK4 -0.53 -8.57 -0.42 3.89e-16 Bipolar disorder; LUSC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg25036284 chr2:26402008 FAM59B -0.7 -9.88 -0.48 2.22e-20 Gut microbiome composition (summer); LUSC cis rs16958440 0.867 rs16948928 chr18:44675821 C/T cg17192377 chr18:44677553 HDHD2 0.69 6.88 0.35 2.99e-11 Sitting height ratio; LUSC cis rs2816062 0.760 rs2745319 chr1:18895078 G/A cg18795169 chr1:18902165 NA -1.01 -24.29 -0.8 8.47e-76 Urate levels in lean individuals; LUSC cis rs9463078 0.817 rs2145826 chr6:44763781 G/A cg25276700 chr6:44698697 NA 0.3 5.84 0.3 1.26e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.63 -10.34 -0.49 6.53e-22 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.68 0.5 4.32e-23 Menopause (age at onset); LUSC cis rs7000551 0.700 rs7431 chr8:22398462 G/A cg12081754 chr8:22256438 SLC39A14 0.42 6.19 0.32 1.79e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7208859 0.623 rs56163556 chr17:29101868 G/C cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg18240062 chr17:79603768 NPLOC4 0.71 12.97 0.58 1.96e-31 Eye color traits; LUSC cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg11244672 chr19:19639970 YJEFN3 0.59 7.32 0.37 1.89e-12 Bipolar disorder; LUSC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg04317338 chr11:64019027 PLCB3 0.68 7.75 0.39 1.12e-13 Mean platelet volume; LUSC cis rs1003719 0.680 rs7275984 chr21:38505696 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs7917772 0.582 rs10786698 chr10:104378750 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.69 11.24 0.52 4.61e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3741151 0.773 rs7945825 chr11:73287140 G/C cg17517138 chr11:73019481 ARHGEF17 0.94 8.09 0.4 1.15e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.62 9.69 0.47 9.85e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21659725 chr3:3221576 CRBN -0.58 -8.34 -0.42 1.92e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6546550 0.935 rs1056482 chr2:70108256 A/T cg02498382 chr2:70120550 SNRNP27 -0.28 -6.97 -0.36 1.74e-11 Prevalent atrial fibrillation; LUSC cis rs2414856 0.510 rs72756996 chr15:64607787 A/G cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg05985134 chr18:33552581 C18orf21 0.51 7.05 0.36 1.01e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08301597 chr12:95397587 NDUFA12 -0.43 -6.11 -0.32 2.83e-9 Electrocardiographic conduction measures; LUSC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg08564027 chr20:61660810 NA 0.9 17.32 0.69 2.14e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs17253792 0.822 rs76205307 chr14:56166038 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.16e-12 Putamen volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27346088 chr10:61469843 SLC16A9 -0.56 -6.95 -0.36 1.91e-11 Bipolar disorder and schizophrenia; LUSC cis rs354225 0.544 rs12713264 chr2:54805218 A/C cg01766943 chr2:54829624 SPTBN1 -0.46 -7.46 -0.38 7.53e-13 Schizophrenia; LUSC cis rs3772130 0.962 rs13065245 chr3:121566729 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 9.71 0.47 8.54e-20 Cognitive performance; LUSC cis rs6964587 0.773 rs62467797 chr7:91889722 G/A cg17063962 chr7:91808500 NA 0.52 7.33 0.37 1.79e-12 Breast cancer; LUSC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs701145 0.537 rs1713847 chr3:153791107 C/A cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg09365446 chr1:150670422 GOLPH3L 0.52 7.99 0.4 2.17e-14 Blood protein levels; LUSC cis rs10849689 1 rs10849689 chr12:110493222 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 9.67 0.47 1.14e-19 Schizophrenia; LUSC cis rs11997175 0.646 rs61693382 chr8:33697255 A/C ch.8.33884649F chr8:33765107 NA 0.45 6.73 0.35 7.29e-11 Body mass index; LUSC cis rs1670533 1.000 rs10003009 chr4:1050849 G/A cg16405210 chr4:1374714 KIAA1530 -0.47 -5.8 -0.3 1.57e-8 Recombination rate (females); LUSC cis rs899997 0.862 rs4887074 chr15:78952110 G/C cg24631222 chr15:78858424 CHRNA5 -0.43 -5.76 -0.3 1.86e-8 Coronary artery disease or large artery stroke; LUSC trans rs9392918 0.967 rs7769495 chr6:7712702 C/G cg12631351 chr5:80256738 RASGRF2 -0.35 -6.0 -0.31 5.02e-9 Height; LUSC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg16346588 chr10:242978 ZMYND11 -0.41 -6.02 -0.31 4.5e-9 Psychosis in Alzheimer's disease; LUSC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg18876405 chr7:65276391 NA -0.55 -8.61 -0.43 2.92e-16 Aortic root size; LUSC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs459571 0.959 rs460888 chr9:136913123 C/G cg01294253 chr9:136912663 BRD3 0.35 6.02 0.31 4.59e-9 Platelet distribution width; LUSC cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2274273 0.662 rs2147970 chr14:55660217 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.67 0.47 1.2e-19 Protein biomarker; LUSC trans rs34421088 0.532 rs2736258 chr8:11170449 C/T cg06636001 chr8:8085503 FLJ10661 0.49 6.95 0.36 1.93e-11 Neuroticism; LUSC trans rs7951105 0.737 rs61886667 chr11:39255607 A/T cg24085930 chr3:21832523 NA 0.55 6.53 0.34 2.44e-10 Free thyroxine concentration; LUSC cis rs17401966 0.928 rs11121531 chr1:10277357 G/A cg19773385 chr1:10388646 KIF1B -0.54 -8.31 -0.41 2.52e-15 Hepatocellular carcinoma; LUSC trans rs7647973 0.677 rs11130211 chr3:49645209 C/T cg21659725 chr3:3221576 CRBN -0.72 -8.2 -0.41 5.17e-15 Menarche (age at onset); LUSC cis rs2806561 0.754 rs10917337 chr1:23300723 G/A cg19743168 chr1:23544995 NA -0.38 -7.87 -0.4 5.11e-14 Height; LUSC cis rs2070488 0.775 rs1132064 chr3:38566519 T/C cg24069376 chr3:38537580 EXOG -0.38 -7.38 -0.37 1.24e-12 Electrocardiographic conduction measures; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07423155 chr1:110527259 AHCYL1 -0.4 -6.06 -0.31 3.61e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs34779708 0.931 rs59418206 chr10:35331624 G/A cg03585969 chr10:35415529 CREM 0.65 9.36 0.46 1.19e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6977660 0.619 rs10950752 chr7:19781531 A/G cg05791153 chr7:19748676 TWISTNB 0.67 7.02 0.36 1.22e-11 Thyroid stimulating hormone; LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg12379764 chr21:47803548 PCNT -0.48 -6.98 -0.36 1.61e-11 Testicular germ cell tumor; LUSC cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs614226 1.000 rs12310837 chr12:120880572 C/T cg01236616 chr12:121019343 POP5 1.19 17.5 0.69 4.19e-49 Type 1 diabetes nephropathy; LUSC cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9902453 0.765 rs2628167 chr17:28064498 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.33 -0.53 2.08e-25 Coffee consumption (cups per day); LUSC cis rs9467773 1.000 rs9467782 chr6:26542773 G/A cg05738196 chr6:26577821 NA 0.81 15.89 0.66 9.79e-43 Intelligence (multi-trait analysis); LUSC cis rs7828089 0.504 rs4872505 chr8:22337996 A/T cg12081754 chr8:22256438 SLC39A14 0.46 6.89 0.35 2.77e-11 Verbal declarative memory; LUSC trans rs877282 1.000 rs2004479 chr10:770854 G/A cg22713356 chr15:30763199 NA 1.07 15.27 0.64 2.57e-40 Uric acid levels; LUSC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg22029157 chr1:209979665 IRF6 0.73 10.82 0.51 1.34e-23 Cleft lip with or without cleft palate; LUSC cis rs7071206 0.853 rs66786803 chr10:79429941 A/G cg07817648 chr10:79422355 NA -0.45 -6.29 -0.33 1.01e-9 Bone mineral density; LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.19e-26 Prudent dietary pattern; LUSC cis rs8114671 0.967 rs6088747 chr20:33754604 G/T cg24642439 chr20:33292090 TP53INP2 0.41 6.02 0.31 4.66e-9 Height; LUSC cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.47 7.11 0.36 7.25e-12 Colorectal cancer; LUSC cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg18132916 chr6:79620363 NA -0.39 -5.99 -0.31 5.41e-9 Intelligence (multi-trait analysis); LUSC cis rs477692 0.597 rs574831 chr10:131379190 C/T cg11019008 chr10:131425282 MGMT -0.4 -5.99 -0.31 5.3e-9 Response to temozolomide; LUSC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg17279839 chr7:150038598 RARRES2 0.54 8.05 0.4 1.47e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg06873352 chr17:61820015 STRADA 0.7 12.66 0.57 2.96e-30 Prudent dietary pattern; LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg27170947 chr2:26402098 FAM59B -0.56 -7.5 -0.38 5.75e-13 Gut microbiome composition (summer); LUSC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg23630131 chr7:65973040 NA -0.21 -6.0 -0.31 5.16e-9 Aortic root size; LUSC trans rs4295623 0.559 rs4841600 chr8:11688148 T/C cg15556689 chr8:8085844 FLJ10661 0.57 8.3 0.41 2.69e-15 Morning vs. evening chronotype; LUSC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg06022373 chr22:39101656 GTPBP1 -0.74 -11.45 -0.53 7.72e-26 Menopause (age at onset); LUSC trans rs11039798 1.000 rs7924372 chr11:48556319 T/A cg15704280 chr7:45808275 SEPT13 0.75 6.44 0.33 4.2e-10 Axial length; LUSC cis rs10733682 0.659 rs867560 chr9:129465233 C/G cg00232160 chr9:129468157 NA -0.38 -6.87 -0.35 3.11e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11625487 0.957 rs7156032 chr14:77951364 G/A cg16900964 chr18:77280354 NFATC1 -0.37 -5.95 -0.31 6.93e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs7267979 0.903 rs6115101 chr20:25229564 C/A cg08601574 chr20:25228251 PYGB 0.47 7.3 0.37 2.14e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4950928 0.823 rs2486065 chr1:203167871 A/G cg17014757 chr1:203156097 CHI3L1 -0.43 -7.8 -0.39 8.05e-14 YKL-40 levels; LUSC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03264133 chr6:25882463 NA -0.71 -11.9 -0.55 1.87e-27 Intelligence (multi-trait analysis); LUSC cis rs2050392 0.928 rs2250077 chr10:30702929 A/G cg18806716 chr10:30721971 MAP3K8 -0.49 -8.04 -0.4 1.61e-14 Inflammatory bowel disease; LUSC trans rs11039798 0.610 rs11530356 chr11:48836290 C/A cg03929089 chr4:120376271 NA 0.72 6.79 0.35 5.2e-11 Axial length; LUSC cis rs7804356 1.000 rs10244986 chr7:26849558 C/A cg03456212 chr7:26904342 SKAP2 -0.54 -6.31 -0.33 8.74e-10 Type 1 diabetes; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg06877462 chr1:205807181 PM20D1 0.49 8.8 0.43 7.55e-17 Menarche (age at onset); LUSC cis rs12579753 0.871 rs10862364 chr12:82201280 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs56235845 0.694 rs11738681 chr5:176761535 A/G cg17509989 chr5:176798049 RGS14 0.67 10.72 0.51 2.95e-23 Hemoglobin concentration;Hematocrit; LUSC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg12292205 chr6:26970375 C6orf41 0.68 11.53 0.53 4.12e-26 Autism spectrum disorder or schizophrenia; LUSC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7618501 1.000 rs7618519 chr3:49772708 A/T cg13072238 chr3:49761600 GMPPB -0.39 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg01652190 chr22:50026171 C22orf34 -0.3 -6.37 -0.33 6.2e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg07274523 chr3:49395745 GPX1 -0.65 -10.02 -0.48 7.72e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -7.91 -0.4 3.74e-14 Glomerular filtration rate (creatinine); LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 13.12 0.58 5.26e-32 Alzheimer's disease; LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC cis rs377070 0.934 rs309418 chr4:123623441 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.46 6.81 0.35 4.56e-11 Mosquito bite size; LUSC trans rs10435719 0.834 rs6985792 chr8:11795335 T/C cg06636001 chr8:8085503 FLJ10661 0.54 8.13 0.41 8.4e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7523050 0.643 rs12729998 chr1:109405505 T/C cg08274380 chr1:109419600 GPSM2 1.09 10.73 0.51 2.88e-23 Fat distribution (HIV); LUSC cis rs420259 0.681 rs26760 chr16:23680286 C/T cg01460202 chr16:23706506 ERN2 -0.3 -5.84 -0.3 1.21e-8 Bipolar disorder; LUSC cis rs1005224 0.929 rs11625260 chr14:76162293 G/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.4 -5.86 -0.31 1.12e-8 Large artery stroke; LUSC cis rs1801251 0.896 rs6719061 chr2:233695885 C/T cg08000102 chr2:233561755 GIGYF2 -0.66 -10.89 -0.51 7.54e-24 Coronary artery disease; LUSC cis rs7851660 0.809 rs7044799 chr9:100665393 A/T cg13688889 chr9:100608707 NA -0.54 -8.43 -0.42 1.05e-15 Strep throat; LUSC cis rs6940638 1.000 rs12215773 chr6:27039233 T/C cg05738196 chr6:26577821 NA -0.5 -5.74 -0.3 2.18e-8 Intelligence (multi-trait analysis); LUSC cis rs9399401 0.601 rs9321870 chr6:142800758 A/T cg03128060 chr6:142623767 GPR126 0.39 6.6 0.34 1.63e-10 Chronic obstructive pulmonary disease; LUSC cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg24642439 chr20:33292090 TP53INP2 0.71 11.51 0.53 4.99e-26 Coronary artery disease; LUSC cis rs9311676 0.656 rs6773193 chr3:58385960 C/T cg26110898 chr3:58419937 PDHB 0.4 6.49 0.33 3.05e-10 Systemic lupus erythematosus; LUSC cis rs6424115 1.000 rs34477640 chr1:24154067 T/C cg15997130 chr1:24165203 NA -0.53 -8.82 -0.43 6.68e-17 Immature fraction of reticulocytes; LUSC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg06008330 chr7:65541103 ASL -0.4 -6.38 -0.33 5.99e-10 Aortic root size; LUSC cis rs500891 0.645 rs2186162 chr6:84163113 A/T cg08257003 chr6:84140564 ME1 0.37 8.97 0.44 2.23e-17 Platelet-derived growth factor BB levels; LUSC cis rs10876993 0.928 rs1628552 chr12:58082142 C/T cg18357645 chr12:58087776 OS9 0.56 8.52 0.42 5.37e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.27e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg15744005 chr10:104629667 AS3MT -0.29 -6.13 -0.32 2.45e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3106136 0.967 rs17310266 chr4:95177051 T/C cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.21 -0.32 1.61e-9 Capecitabine sensitivity; LUSC trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg15704280 chr7:45808275 SEPT13 0.94 13.51 0.59 1.74e-33 Coronary artery disease; LUSC cis rs1538970 0.924 rs11211111 chr1:45908782 C/T cg05343316 chr1:45956843 TESK2 0.66 9.01 0.44 1.62e-17 Platelet count; LUSC cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg00857998 chr1:205179979 DSTYK 0.59 8.89 0.44 3.85e-17 Mean corpuscular volume;Mean platelet volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg08733960 chr6:52529248 LOC730101 0.42 6.23 0.32 1.43e-9 Triglycerides; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13645767 chr9:97766849 C9orf3 0.43 6.21 0.32 1.6e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12759997 chr1:54518742 TMEM59;C1orf83 -0.54 -6.95 -0.36 1.9e-11 Bipolar disorder and schizophrenia; LUSC cis rs6500395 0.926 rs11076571 chr16:48598064 A/G cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.94e-9 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs72674100 1.000 rs10005324 chr4:97989202 G/C cg09670535 chr1:18959427 PAX7 -0.62 -6.34 -0.33 7.58e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg08677398 chr8:58056175 NA 0.52 6.36 0.33 6.6e-10 Developmental language disorder (linguistic errors); LUSC cis rs12421382 0.636 rs1439519 chr11:109378438 A/G cg16359550 chr11:109292809 C11orf87 0.36 6.07 0.32 3.55e-9 Schizophrenia; LUSC cis rs4363385 0.818 rs382653 chr1:153006761 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs2227930 0.506 rs2306699 chr3:142122451 T/A cg16271453 chr3:142027066 XRN1 -0.55 -9.71 -0.47 8.4e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs5758511 0.513 rs7292782 chr22:42200324 A/C cg00645731 chr22:42541494 CYP2D7P1 -0.4 -7.58 -0.38 3.38e-13 Birth weight; LUSC cis rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05901451 chr6:126070800 HEY2 0.77 12.43 0.56 2.06e-29 Endometrial cancer; LUSC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg20684491 chr1:25596433 NA 0.36 5.65 0.3 3.43e-8 Erythrocyte sedimentation rate; LUSC cis rs6987853 0.787 rs10958722 chr8:42425487 T/C cg09913449 chr8:42400586 C8orf40 0.5 8.45 0.42 9.37e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.67 0.65 7.43e-42 Bladder cancer; LUSC cis rs2933343 0.729 rs6767104 chr3:128648117 G/T cg11901034 chr3:128598214 ACAD9 0.39 6.1 0.32 2.91e-9 IgG glycosylation; LUSC cis rs11098499 0.779 rs10011097 chr4:120310359 T/G cg24375607 chr4:120327624 NA 0.77 11.39 0.53 1.32e-25 Corneal astigmatism; LUSC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs7681440 0.904 rs2870029 chr4:90772057 G/T cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.3 1.2e-8 Dementia with Lewy bodies; LUSC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs4930103 0.591 rs11042048 chr11:1986240 C/G cg23202291 chr11:1979235 NA 0.49 7.64 0.39 2.33e-13 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7772486 0.875 rs2073287 chr6:146350264 T/C cg23711669 chr6:146136114 FBXO30 0.85 15.09 0.64 1.32e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs894734 0.567 rs7138907 chr12:54324576 C/T cg17410650 chr12:54324560 NA -0.58 -10.51 -0.5 1.66e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC trans rs10511400 0.867 rs6777971 chr3:119936272 T/C cg02809009 chr19:50354510 PTOV1 -0.69 -5.99 -0.31 5.46e-9 Economic and political preferences (feminism/equality); LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg04944784 chr2:26401820 FAM59B -0.74 -10.91 -0.51 6.48e-24 Gut microbiome composition (summer); LUSC cis rs9815354 0.812 rs58360908 chr3:41839837 A/G cg03022575 chr3:42003672 ULK4 0.85 8.58 0.42 3.72e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg07424592 chr7:64974309 NA 0.67 5.89 0.31 9.55e-9 Diabetic kidney disease; LUSC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg21361702 chr7:150065534 REPIN1 0.57 8.02 0.4 1.85e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs1832871 0.683 rs6908487 chr6:158713047 G/T cg07165851 chr6:158734300 TULP4 0.5 7.66 0.39 2.05e-13 Height; LUSC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11644478 chr21:40555479 PSMG1 -0.76 -13.53 -0.59 1.52e-33 Cognitive function; LUSC cis rs11105298 0.891 rs10858890 chr12:89907166 A/G cg00757033 chr12:89920650 WDR51B 0.59 10.36 0.49 5.37e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs61931739 0.500 rs7311284 chr12:34478477 C/G cg13010199 chr12:38710504 ALG10B 0.68 10.74 0.51 2.68e-23 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs8036030 0.604 rs11852686 chr15:74715205 A/G cg10253484 chr15:75165896 SCAMP2 -0.5 -7.56 -0.38 3.97e-13 Airflow obstruction; LUSC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4474465 0.915 rs12794810 chr11:78212743 T/C cg27205649 chr11:78285834 NARS2 0.5 5.79 0.3 1.64e-8 Alzheimer's disease (survival time); LUSC trans rs7980799 0.682 rs61927702 chr12:33631695 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.61 -0.43 3.01e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs6494488 0.500 rs72744729 chr15:65038484 G/A cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs11971779 0.680 rs4732369 chr7:139069173 C/A cg07862535 chr7:139043722 LUC7L2 0.57 7.09 0.36 7.93e-12 Diisocyanate-induced asthma; LUSC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12579753 1.000 rs2400979 chr12:82197353 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.12 -0.32 2.69e-9 Resting heart rate; LUSC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.82 -0.3 1.36e-8 Tonsillectomy; LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg05025164 chr4:1340916 KIAA1530 -0.62 -9.52 -0.46 3.74e-19 Longevity; LUSC cis rs6841333 0.539 rs4859592 chr4:76948664 A/G cg00809888 chr4:76862425 NAAA 0.35 5.78 0.3 1.67e-8 Monokine induced by gamma interferon levels; LUSC cis rs12681287 0.511 rs4129535 chr8:87524094 G/T cg27223183 chr8:87520930 FAM82B -0.54 -7.15 -0.36 5.67e-12 Caudate activity during reward; LUSC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg08677398 chr8:58056175 NA 0.41 5.73 0.3 2.19e-8 Developmental language disorder (linguistic errors); LUSC cis rs4722166 0.564 rs1800797 chr7:22766221 A/G cg26061582 chr7:22766209 IL6 0.48 6.64 0.34 1.28e-10 Lung cancer; LUSC trans rs7937682 0.889 rs558736 chr11:111500760 C/G cg18187862 chr3:45730750 SACM1L 0.56 7.1 0.36 7.61e-12 Primary sclerosing cholangitis; LUSC cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg13010199 chr12:38710504 ALG10B 0.69 11.39 0.53 1.28e-25 Heart rate; LUSC cis rs1577917 0.958 rs1591438 chr6:86525214 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.75 -0.35 6.41e-11 Response to antipsychotic treatment; LUSC cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg23711669 chr6:146136114 FBXO30 0.93 18.36 0.71 1.46e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs4319547 0.615 rs2341439 chr12:122848096 C/G cg05707623 chr12:122985044 ZCCHC8 -0.62 -7.87 -0.4 5.09e-14 Body mass index; LUSC trans rs208520 0.754 rs851592 chr6:66875175 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -16.25 -0.66 3.52e-44 Exhaled nitric oxide output; LUSC trans rs9650657 0.504 rs6601566 chr8:11042974 G/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.08 -0.36 8.44e-12 Neuroticism; LUSC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.27 -0.32 1.09e-9 Total body bone mineral density; LUSC cis rs4595586 0.525 rs7972595 chr12:39338000 G/A cg09788416 chr12:39539408 NA 0.38 5.67 0.3 3.04e-8 Morning vs. evening chronotype; LUSC trans rs6502050 0.799 rs7212023 chr17:80170354 G/A cg07393940 chr7:158741817 NA 0.36 6.45 0.33 3.84e-10 Life satisfaction; LUSC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg17971929 chr21:40555470 PSMG1 0.78 13.41 0.59 4.32e-33 Cognitive function; LUSC cis rs7577851 0.904 rs12475178 chr2:69730942 C/T cg10773587 chr2:69614142 GFPT1 0.51 5.96 0.31 6.36e-9 Parkinson's disease (age of onset); LUSC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.69 -10.85 -0.51 1.06e-23 Monocyte percentage of white cells; LUSC cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg13010199 chr12:38710504 ALG10B -0.49 -7.51 -0.38 5.49e-13 Morning vs. evening chronotype; LUSC cis rs7681440 0.715 rs17016305 chr4:90791381 A/G cg15133208 chr4:90757351 SNCA -0.36 -6.05 -0.31 3.9e-9 Dementia with Lewy bodies; LUSC cis rs8017423 0.967 rs61996919 chr14:90701803 A/C cg14092571 chr14:90743983 NA -0.35 -5.65 -0.3 3.35e-8 Mortality in heart failure; LUSC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg26441486 chr22:50317300 CRELD2 0.46 7.07 0.36 9.35e-12 Schizophrenia; LUSC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg00310523 chr12:86230176 RASSF9 -0.42 -7.7 -0.39 1.52e-13 Major depressive disorder; LUSC cis rs400736 0.860 rs371452 chr1:8084051 C/T cg25007680 chr1:8021821 PARK7 0.57 9.07 0.44 1.01e-17 Response to antidepressants and depression; LUSC cis rs1790761 0.667 rs658768 chr11:67337808 G/A cg00864171 chr11:67383662 NA 0.35 6.14 0.32 2.31e-9 Mean corpuscular volume; LUSC cis rs56399783 0.901 rs17132744 chr7:2874982 T/C cg19731401 chr7:2775893 GNA12 0.68 9.29 0.45 2.05e-18 Childhood ear infection; LUSC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.76 0.68 3.58e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg22800045 chr5:56110881 MAP3K1 0.77 10.03 0.48 7.09e-21 Initial pursuit acceleration; LUSC cis rs9395066 0.545 rs10948192 chr6:44947321 G/A cg25276700 chr6:44698697 NA 0.28 5.78 0.3 1.75e-8 Height; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.66 10.24 0.49 1.37e-21 Lymphocyte counts; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg03188948 chr7:1209495 NA 0.42 6.19 0.32 1.75e-9 Longevity;Endometriosis; LUSC cis rs2439831 0.867 rs2260160 chr15:43895643 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.75 7.52 0.38 5.1e-13 Lung cancer in ever smokers; LUSC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg12463550 chr7:65579703 CRCP 0.55 8.21 0.41 4.85e-15 Aortic root size; LUSC cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.65 -0.3 3.51e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs193541 0.530 rs1466371 chr5:122083788 T/C cg19077854 chr5:122220652 SNX24 0.36 7.15 0.36 5.53e-12 Glucose homeostasis traits; LUSC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs57221529 0.766 rs72703075 chr5:592819 C/T cg16624210 chr5:671434 TPPP 0.53 6.44 0.33 4.28e-10 Lung disease severity in cystic fibrosis; LUSC cis rs9902453 1.000 rs4074170 chr17:28381141 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.41 -0.42 1.18e-15 Coffee consumption (cups per day); LUSC trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg15704280 chr7:45808275 SEPT13 0.73 8.39 0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs11992162 0.967 rs7836456 chr8:11829175 T/G cg21775007 chr8:11205619 TDH 0.52 7.4 0.38 1.13e-12 Monocyte count; LUSC cis rs137699 0.695 rs137653 chr22:39732171 A/G cg11247378 chr22:39784982 NA 0.35 6.11 0.32 2.85e-9 IgG glycosylation; LUSC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg17366294 chr4:99064904 C4orf37 0.54 9.52 0.46 3.65e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs13315871 1.000 rs71311873 chr3:58447106 C/A cg12435725 chr3:58293450 RPP14 -0.7 -6.93 -0.35 2.21e-11 Cholesterol, total; LUSC cis rs1670533 1.000 rs2045068 chr4:1052212 G/A cg02018176 chr4:1364513 KIAA1530 0.46 6.42 0.33 4.76e-10 Recombination rate (females); LUSC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg24675056 chr1:15929824 NA 0.45 7.65 0.39 2.12e-13 Systolic blood pressure; LUSC cis rs6430585 0.528 rs114760827 chr2:136661110 G/A cg07169764 chr2:136633963 MCM6 1.16 17.8 0.7 2.5e-50 Corneal structure; LUSC cis rs317689 0.658 rs479971 chr12:69672471 A/G cg11871910 chr12:69753446 YEATS4 0.45 5.93 0.31 7.38e-9 Response to diuretic therapy; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12753518 chr1:28414763 EYA3 0.38 6.01 0.31 4.76e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg00750074 chr16:89608354 SPG7 0.45 6.8 0.35 4.96e-11 Multiple myeloma (IgH translocation); LUSC cis rs9325144 0.560 rs10785573 chr12:38654166 G/A cg26384229 chr12:38710491 ALG10B -0.66 -10.27 -0.49 1.11e-21 Morning vs. evening chronotype; LUSC cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs9527 0.590 rs7073323 chr10:104797423 A/C cg05855489 chr10:104503620 C10orf26 0.51 7.45 0.38 8.31e-13 Arsenic metabolism; LUSC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg18904891 chr8:8559673 CLDN23 0.4 6.2 0.32 1.66e-9 Mood instability; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg07092213 chr7:1199455 ZFAND2A -0.68 -11.25 -0.52 3.98e-25 Longevity;Endometriosis; LUSC trans rs941408 0.515 rs878893 chr19:2781325 A/G cg19676328 chr12:49525230 TUBA1B -0.53 -7.53 -0.38 4.8e-13 Total cholesterol levels; LUSC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.53 -0.38 4.87e-13 Personality dimensions; LUSC cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg14395844 chr9:139980277 LOC100289341;MAN1B1 0.48 7.25 0.37 2.98e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs9902453 0.765 rs2617883 chr17:28120488 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.67 -0.54 1.26e-26 Coffee consumption (cups per day); LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg25288140 chr17:41278341 BRCA1;NBR2 -0.39 -5.96 -0.31 6.32e-9 Menopause (age at onset); LUSC cis rs17539620 0.519 rs871071 chr6:154837667 T/C cg20019720 chr6:154832845 CNKSR3 0.62 9.57 0.46 2.54e-19 Lipoprotein (a) levels; LUSC cis rs3820068 0.580 rs12746773 chr1:16001588 C/T cg24675056 chr1:15929824 NA 0.43 7.12 0.36 6.69e-12 Systolic blood pressure; LUSC cis rs3617 0.539 rs9825369 chr3:52953311 T/C cg18404041 chr3:52824283 ITIH1 0.44 7.85 0.39 5.66e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg16584290 chr5:462447 EXOC3 -0.34 -5.8 -0.3 1.52e-8 Cystic fibrosis severity; LUSC cis rs10089 0.904 rs2228112 chr5:127469859 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.06 0.55 4.66e-28 Ileal carcinoids; LUSC cis rs9467773 0.620 rs2494700 chr6:26631306 C/T cg11502198 chr6:26597334 ABT1 0.71 12.06 0.55 4.63e-28 Intelligence (multi-trait analysis); LUSC cis rs9549260 0.755 rs7335520 chr13:41196407 C/T cg21288729 chr13:41239152 FOXO1 0.6 9.14 0.45 6.27e-18 Red blood cell count; LUSC cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14442939 chr10:27389572 ANKRD26 0.89 9.43 0.46 6.88e-19 Breast cancer; LUSC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.58 -9.42 -0.46 7.8e-19 Personality dimensions; LUSC cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg26384229 chr12:38710491 ALG10B 0.92 17.77 0.7 3.32e-50 Heart rate; LUSC cis rs7605827 0.930 rs10200346 chr2:15635728 A/C cg19274914 chr2:15703543 NA 0.47 9.12 0.45 7.34e-18 Educational attainment (years of education); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24950336 chr3:113464879 ATP6V1A;NAA50 0.41 6.18 0.32 1.91e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg17173187 chr15:85201210 NMB 0.35 6.38 0.33 5.78e-10 Schizophrenia; LUSC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg06740227 chr12:86229804 RASSF9 0.43 6.76 0.35 6.18e-11 Major depressive disorder; LUSC cis rs968451 1.000 rs11703434 chr22:39698915 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.68 9.0 0.44 1.8e-17 Primary biliary cholangitis; LUSC cis rs6489882 0.867 rs1859332 chr12:113371114 T/C cg20102336 chr12:113376681 OAS3 -0.42 -6.17 -0.32 1.98e-9 Chronic lymphocytic leukemia; LUSC cis rs1034435 0.755 rs713923 chr22:48891519 C/T cg05992904 chr22:48892994 FAM19A5 0.39 7.47 0.38 7.06e-13 Late-onset Alzheimer's disease; LUSC cis rs3812831 0.630 rs9562129 chr13:114917152 A/G cg15896084 chr13:114927664 NA 0.4 7.26 0.37 2.74e-12 Schizophrenia; LUSC cis rs4073582 0.516 rs1151539 chr11:66031660 C/T cg16950941 chr11:66035639 RAB1B 0.54 8.01 0.4 1.97e-14 Gout; LUSC cis rs2845885 0.793 rs35927325 chr11:63882495 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.81 7.47 0.38 7.11e-13 Body mass index; LUSC cis rs1577917 0.771 rs2484355 chr6:86394403 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.53 -8.53 -0.42 5.12e-16 Response to antipsychotic treatment; LUSC cis rs11051970 0.879 rs10844201 chr12:32575029 A/G cg24626660 chr12:32551988 NA 0.33 5.69 0.3 2.82e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9914988 0.778 rs4794837 chr17:27110024 T/C cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4363385 0.667 rs454245 chr1:153031979 A/C cg00922841 chr1:152955080 SPRR1A 0.42 7.27 0.37 2.54e-12 Inflammatory skin disease; LUSC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg00509249 chr6:109615579 CCDC162 -0.34 -6.05 -0.31 3.83e-9 Reticulocyte fraction of red cells; LUSC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg10792982 chr14:105748885 BRF1 0.51 8.92 0.44 3.14e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13012494 chr21:47604986 C21orf56 0.47 7.13 0.36 6.42e-12 Testicular germ cell tumor; LUSC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg23791538 chr6:167370224 RNASET2 -0.37 -5.71 -0.3 2.52e-8 Crohn's disease; LUSC cis rs10191773 0.535 rs56187472 chr2:113111668 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.8 8.39 0.42 1.43e-15 Yeast infection; LUSC cis rs11971779 0.680 rs2355786 chr7:139065622 A/C cg07862535 chr7:139043722 LUC7L2 -0.56 -7.01 -0.36 1.3e-11 Diisocyanate-induced asthma; LUSC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg18252515 chr7:66147081 NA -1.25 -13.99 -0.61 2.56e-35 Diabetic kidney disease; LUSC cis rs2302729 0.578 rs2302728 chr12:2774668 A/C cg19945202 chr12:2788847 CACNA1C 0.35 6.22 0.32 1.48e-9 Sleep quality; LUSC cis rs10761482 0.859 rs4948408 chr10:62110213 T/A cg18175470 chr10:62150864 ANK3 -0.5 -7.05 -0.36 1.05e-11 Schizophrenia; LUSC cis rs6696846 0.740 rs12125465 chr1:205074854 C/A cg00857998 chr1:205179979 DSTYK 0.64 10.11 0.48 3.78e-21 Red blood cell count; LUSC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6599077 0.724 rs11129862 chr3:40113047 A/C cg13683864 chr3:40499215 RPL14 0.56 7.67 0.39 1.96e-13 Sleep-related phenotypes; LUSC cis rs977987 0.806 rs12051136 chr16:75435731 G/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.6 -0.34 1.6e-10 Dupuytren's disease; LUSC cis rs2760061 0.583 rs1774757 chr1:228211135 C/G cg18477163 chr1:228402036 OBSCN 0.57 9.54 0.46 3.15e-19 Diastolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00560671 chr13:21635735 LATS2 -0.41 -6.01 -0.31 4.98e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3125734 0.660 rs4979780 chr10:63992740 A/C cg09941381 chr10:64027924 RTKN2 -0.38 -7.05 -0.36 1.02e-11 Rheumatoid arthritis; LUSC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg14552801 chr7:65878734 NA 0.37 5.67 0.3 3.15e-8 Aortic root size; LUSC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11890956 chr21:40555474 PSMG1 1.01 18.98 0.72 5.41e-55 Cognitive function; LUSC cis rs870825 0.616 rs4437299 chr4:185643223 T/A cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs4974559 0.947 rs28540746 chr4:1352954 G/A cg02980000 chr4:1222292 CTBP1 0.74 7.37 0.37 1.33e-12 Systolic blood pressure; LUSC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg11608241 chr8:8085544 FLJ10661 0.4 5.84 0.3 1.21e-8 Mood instability; LUSC cis rs6500395 1.000 rs1039340 chr16:48574637 A/C cg04672837 chr16:48644449 N4BP1 0.46 6.82 0.35 4.17e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18758796 chr5:131593413 PDLIM4 0.52 8.87 0.44 4.49e-17 Acylcarnitine levels; LUSC cis rs9650657 0.801 rs718741 chr8:10614384 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.09 -0.32 3.13e-9 Neuroticism; LUSC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg12756686 chr19:29218302 NA 0.47 5.79 0.3 1.64e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs1577917 0.917 rs12202170 chr6:86590386 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.88 -0.44 4.24e-17 Response to antipsychotic treatment; LUSC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.72 -0.3 2.31e-8 Depression; LUSC cis rs1670533 1.000 rs28562028 chr4:1055115 G/A cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs868036 1.000 rs6494694 chr15:68057142 A/C cg05925327 chr15:68127851 NA 0.33 5.85 0.3 1.19e-8 Restless legs syndrome; LUSC cis rs9308433 0.505 rs867446 chr1:214502322 G/T cg06198575 chr1:214491504 SMYD2 0.47 7.22 0.37 3.61e-12 IgG glycosylation; LUSC cis rs7914558 1.000 rs1926030 chr10:104855656 T/C cg05855489 chr10:104503620 C10orf26 0.58 9.29 0.45 2.03e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6580649 0.941 rs4760618 chr12:48434767 G/A cg24011408 chr12:48396354 COL2A1 -0.51 -6.81 -0.35 4.45e-11 Lung cancer; LUSC cis rs208520 0.754 rs851592 chr6:66875175 G/T cg07460842 chr6:66804631 NA -1.11 -16.94 -0.68 6.59e-47 Exhaled nitric oxide output; LUSC cis rs5758659 0.652 rs133321 chr22:42405322 A/G cg15557168 chr22:42548783 NA -0.33 -5.67 -0.3 3.03e-8 Cognitive function; LUSC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -10.1 -0.48 4.1e-21 Autism spectrum disorder or schizophrenia; LUSC cis rs2797685 0.755 rs41402249 chr1:7822723 C/G cg04725166 chr1:7887271 PER3 0.45 5.8 0.3 1.51e-8 Crohn's disease; LUSC cis rs13401104 0.796 rs72620809 chr2:237116050 T/C cg19324714 chr2:237145437 ASB18 0.43 5.65 0.3 3.43e-8 Educational attainment; LUSC cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg23788917 chr6:8435910 SLC35B3 0.51 7.58 0.38 3.38e-13 Motion sickness; LUSC cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg04851639 chr8:1020857 NA 0.38 8.09 0.4 1.15e-14 Schizophrenia; LUSC cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg05707623 chr12:122985044 ZCCHC8 -0.57 -7.98 -0.4 2.44e-14 Body mass index; LUSC cis rs7712401 0.580 rs30041 chr5:122275353 G/C cg19077854 chr5:122220652 SNX24 0.42 9.32 0.45 1.68e-18 Mean platelet volume; LUSC cis rs4663866 1.000 rs4663300 chr2:239181491 T/C cg16914508 chr2:239161102 PER2 0.69 7.39 0.37 1.17e-12 Irritable bowel syndrome; LUSC trans rs459571 1.000 rs456207 chr9:136911140 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -12.35 -0.56 4.11e-29 Platelet distribution width; LUSC trans rs12579753 0.879 rs11115007 chr12:82164673 A/T cg07923666 chr12:49932857 KCNH3 -0.49 -6.27 -0.32 1.14e-9 Resting heart rate; LUSC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg06219351 chr7:158114137 PTPRN2 -0.51 -9.32 -0.45 1.64e-18 Calcium levels; LUSC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg23758822 chr17:41437982 NA 1.03 20.14 0.74 1.26e-59 Menopause (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00243897 chr12:122326549 PSMD9 -0.49 -6.13 -0.32 2.49e-9 Bipolar disorder and schizophrenia; LUSC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg22532475 chr10:104410764 TRIM8 -0.3 -5.92 -0.31 7.9e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg17971929 chr21:40555470 PSMG1 0.77 12.99 0.58 1.7e-31 Cognitive function; LUSC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg08859206 chr1:53392774 SCP2 -0.51 -8.53 -0.42 5.16e-16 Monocyte count; LUSC cis rs4629710 0.592 rs9492868 chr6:131542238 A/C cg12606694 chr6:131520996 AKAP7 0.61 9.38 0.46 1.06e-18 Multiple myeloma (IgH translocation); LUSC cis rs2692947 0.770 rs2315417 chr2:96500289 T/C cg23100626 chr2:96804247 ASTL 0.26 6.46 0.33 3.8e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs7259376 0.936 rs8110854 chr19:22549453 C/T cg08058610 chr19:52674483 ZNF836 0.38 5.95 0.31 6.93e-9 Menopause (age at onset); LUSC cis rs740160 0.558 rs17161662 chr7:98907396 C/T cg24650262 chr7:98904301 NA 0.6 6.62 0.34 1.47e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs360798 0.532 rs360800 chr2:62954326 C/T cg17519650 chr2:63277830 OTX1 -0.51 -7.13 -0.36 6.21e-12 Coronary artery disease; LUSC cis rs7107174 0.892 rs11237463 chr11:78060464 A/G cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg06671706 chr8:8559999 CLDN23 0.45 6.08 0.32 3.32e-9 Obesity-related traits; LUSC cis rs9467773 0.873 rs9295698 chr6:26566099 T/A cg09904177 chr6:26538194 HMGN4 0.76 14.13 0.61 7.08e-36 Intelligence (multi-trait analysis); LUSC cis rs11587682 0.760 rs12141218 chr1:150448707 T/C cg11822372 chr1:151115635 SEMA6C -0.43 -5.74 -0.3 2.18e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg17724175 chr1:150552817 MCL1 0.37 6.67 0.34 1.05e-10 Tonsillectomy; LUSC cis rs12210905 0.925 rs12200985 chr6:27004892 G/T cg23155468 chr6:27110703 HIST1H2BK -0.69 -6.01 -0.31 4.74e-9 Hip circumference adjusted for BMI; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg06877462 chr1:205807181 PM20D1 -0.33 -6.04 -0.31 4.22e-9 Monocyte percentage of white cells; LUSC cis rs225245 0.782 rs178649 chr17:33908197 C/G cg05299278 chr17:33885742 SLFN14 0.31 6.82 0.35 4.37e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9905704 0.633 rs2632511 chr17:56490989 G/A cg19466818 chr17:56409534 MIR142 -0.32 -6.06 -0.31 3.73e-9 Testicular germ cell tumor; LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg25894440 chr7:65020034 NA 0.39 6.1 0.32 2.99e-9 Calcium levels; LUSC cis rs9640161 0.830 rs35635199 chr7:150063342 C/T cg17279839 chr7:150038598 RARRES2 0.4 6.08 0.32 3.26e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs7674212 0.570 rs2069274 chr4:104020781 C/G cg16532752 chr4:104119610 CENPE -0.51 -7.56 -0.38 3.94e-13 Type 2 diabetes; LUSC cis rs6964587 0.692 rs6970629 chr7:91846599 T/C cg17063962 chr7:91808500 NA 0.61 10.19 0.49 2e-21 Breast cancer; LUSC cis rs9303542 0.559 rs12939811 chr17:46607958 A/T cg09704116 chr17:46666958 LOC404266 -0.38 -6.74 -0.35 6.89e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.35 -7.59 -0.38 3.17e-13 Cystic fibrosis severity; LUSC cis rs7267979 0.586 rs6050445 chr20:25195394 C/T cg08601574 chr20:25228251 PYGB 0.44 6.68 0.34 9.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg04850211 chr1:228464232 OBSCN 0.32 5.71 0.3 2.54e-8 Diastolic blood pressure; LUSC cis rs3859192 0.577 rs25645 chr17:38173143 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.54 0.57 8.07e-30 White blood cell count; LUSC cis rs9811920 0.965 rs9289981 chr3:99868104 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.34 -5.78 -0.3 1.67e-8 Axial length; LUSC cis rs2073300 1.000 rs6048825 chr20:23457671 T/C cg09953122 chr20:23471693 CST8 -0.69 -6.86 -0.35 3.28e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg25173405 chr17:45401733 C17orf57 0.42 6.85 0.35 3.49e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs1864729 1.000 rs2583506 chr8:98281847 G/A cg08679828 chr8:102218111 ZNF706 -0.84 -7.77 -0.39 1e-13 Estradiol plasma levels (breast cancer); LUSC cis rs11252926 0.797 rs61837235 chr10:489363 G/A cg18196295 chr10:418757 DIP2C -0.48 -7.12 -0.36 6.5e-12 Psychosis in Alzheimer's disease; LUSC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg01416388 chr22:39784598 NA -0.41 -6.35 -0.33 7.17e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9393777 0.588 rs4518487 chr6:26467531 A/G cg12826209 chr6:26865740 GUSBL1 0.67 7.76 0.39 1.05e-13 Intelligence (multi-trait analysis); LUSC trans rs561341 0.714 rs7218466 chr17:30263314 A/G cg20587970 chr11:113659929 NA -0.98 -12.21 -0.56 1.38e-28 Hip circumference adjusted for BMI; LUSC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg21963583 chr11:68658836 MRPL21 0.56 8.08 0.4 1.19e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg18305652 chr10:134549665 INPP5A 0.44 6.64 0.34 1.3e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg12463550 chr7:65579703 CRCP 0.54 8.11 0.41 9.64e-15 Aortic root size; LUSC cis rs7712401 0.692 rs6881135 chr5:122080371 A/T cg19077854 chr5:122220652 SNX24 -0.33 -7.24 -0.37 3.02e-12 Mean platelet volume; LUSC cis rs56283067 0.547 rs12192267 chr6:45393787 C/T cg20913747 chr6:44695427 NA -0.42 -6.07 -0.32 3.56e-9 Total body bone mineral density; LUSC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg03806693 chr22:41940476 POLR3H -0.96 -13.04 -0.58 1.08e-31 Vitiligo; LUSC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg18252515 chr7:66147081 NA -1.18 -13.6 -0.6 8.06e-34 Diabetic kidney disease; LUSC cis rs75920871 0.528 rs11216245 chr11:116913202 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.48 -6.05 -0.31 3.92e-9 Subjective well-being; LUSC cis rs67460515 0.892 rs13073147 chr3:161045237 T/C cg03342759 chr3:160939853 NMD3 -0.52 -7.42 -0.38 9.59e-13 Parkinson's disease; LUSC cis rs1577917 0.874 rs1838954 chr6:86565478 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.68 -0.43 1.76e-16 Response to antipsychotic treatment; LUSC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.49 -6.59 -0.34 1.73e-10 Tonsillectomy; LUSC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg05585544 chr11:47624801 NA -0.42 -7.46 -0.38 7.56e-13 Subjective well-being; LUSC cis rs4851254 0.517 rs13020141 chr2:100653842 G/A cg07810366 chr2:100720526 AFF3 -0.47 -6.04 -0.31 4e-9 Intelligence (multi-trait analysis); LUSC cis rs1335645 0.570 rs12403848 chr1:111627231 C/T cg00321911 chr1:111669324 DRAM2 -0.57 -6.15 -0.32 2.24e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.76 0.35 6.03e-11 Obesity-related traits; LUSC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg14584255 chr6:163149320 PACRG;PARK2 -0.4 -7.86 -0.4 5.25e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg15649852 chr7:65879115 NA 0.43 5.93 0.31 7.74e-9 Aortic root size; LUSC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg11366901 chr6:160182831 ACAT2 0.93 13.24 0.59 1.93e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs9517320 0.934 rs9517319 chr13:99125956 T/G cg07423050 chr13:99094983 FARP1 0.33 6.33 0.33 7.74e-10 Longevity; LUSC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg06212747 chr3:49208901 KLHDC8B 0.54 7.13 0.36 6.21e-12 Parkinson's disease; LUSC trans rs7615952 0.641 rs12491577 chr3:125731131 C/T cg07211511 chr3:129823064 LOC729375 -0.8 -10.6 -0.5 7.71e-23 Blood pressure (smoking interaction); LUSC cis rs2219968 1.000 rs13263569 chr8:78954480 A/G cg00738934 chr8:78996279 NA 0.34 6.17 0.32 1.94e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg00343986 chr7:65444356 GUSB -0.38 -5.73 -0.3 2.29e-8 Aortic root size; LUSC cis rs7799006 0.862 rs3757439 chr7:2272122 C/T cg08027265 chr7:2291960 NA -0.42 -7.37 -0.37 1.34e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg19318889 chr4:1322082 MAEA 0.45 7.28 0.37 2.42e-12 Obesity-related traits; LUSC cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg01884057 chr2:25150051 NA 0.44 10.17 0.49 2.41e-21 Body mass index; LUSC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg08499158 chr17:42289980 UBTF -0.53 -8.79 -0.43 8.24e-17 Total body bone mineral density; LUSC cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg13535736 chr9:111863775 C9orf5 -0.4 -6.6 -0.34 1.6e-10 Menarche (age at onset); LUSC cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg15691649 chr6:25882328 NA -0.38 -6.22 -0.32 1.49e-9 Blood metabolite levels; LUSC cis rs7786808 0.608 rs9692003 chr7:158204696 G/A cg09998033 chr7:158218633 PTPRN2 0.41 6.42 0.33 4.63e-10 Obesity-related traits; LUSC cis rs9911578 0.835 rs58647683 chr17:56483194 T/C cg12560992 chr17:57184187 TRIM37 -0.72 -12.68 -0.57 2.45e-30 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07818646 chr13:51483769 RNASEH2B 0.45 6.37 0.33 6.24e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs950169 0.580 rs11636189 chr15:85193554 G/A cg17173187 chr15:85201210 NMB 0.49 9.49 0.46 4.65e-19 Schizophrenia; LUSC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg19318889 chr4:1322082 MAEA 0.45 7.28 0.37 2.42e-12 Obesity-related traits; LUSC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg02018176 chr4:1364513 KIAA1530 0.55 7.05 0.36 1.02e-11 Recombination rate (females); LUSC cis rs3845702 1.000 rs9989852 chr2:180839707 G/A cg01881094 chr2:180872142 CWC22 -0.82 -10.71 -0.51 3.19e-23 Schizophrenia; LUSC cis rs17407555 0.697 rs56079809 chr4:10102736 C/A cg11266682 chr4:10021025 SLC2A9 -0.46 -5.99 -0.31 5.29e-9 Schizophrenia (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05021923 chr6:18387560 RNF144B 0.69 6.14 0.32 2.28e-9 Cognitive performance; LUSC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -7.85 -0.39 5.67e-14 Hemoglobin concentration; LUSC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg06238570 chr21:40685208 BRWD1 -0.65 -10.84 -0.51 1.12e-23 Cognitive function; LUSC cis rs16910800 1.000 rs12420544 chr11:23200505 A/C cg20040320 chr11:23191996 NA -0.43 -6.34 -0.33 7.37e-10 Cancer; LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg22535103 chr8:58192502 C8orf71 -0.57 -7.03 -0.36 1.16e-11 Developmental language disorder (linguistic errors); LUSC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg22105103 chr4:187893119 NA 0.69 12.71 0.57 1.82e-30 Lobe attachment (rater-scored or self-reported); LUSC trans rs57221529 0.713 rs72703072 chr5:590626 A/G cg25482853 chr8:67687455 SGK3 1.18 16.74 0.68 4.07e-46 Lung disease severity in cystic fibrosis; LUSC cis rs9325144 0.624 rs12231544 chr12:38901956 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.41 -0.38 1.06e-12 Morning vs. evening chronotype; LUSC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg15605315 chr1:45957053 TESK2 0.46 7.33 0.37 1.78e-12 High light scatter reticulocyte count; LUSC cis rs2235544 0.542 rs11206272 chr1:54470035 G/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs4144743 1.000 rs7223003 chr17:45324293 G/A cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs238295 0.766 rs6139762 chr20:5546694 C/T cg15842884 chr20:5591925 RP5-1022P6.2 0.44 5.91 0.31 8.43e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg00310523 chr12:86230176 RASSF9 0.45 8.02 0.4 1.82e-14 Major depressive disorder; LUSC cis rs6546886 0.912 rs7589915 chr2:74282130 G/C cg14702570 chr2:74259524 NA -0.3 -5.67 -0.3 3.08e-8 Dialysis-related mortality; LUSC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg26695010 chr11:65641043 EFEMP2 0.41 5.74 0.3 2.14e-8 Breast cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02923393 chr16:1543003 TELO2 0.44 6.39 0.33 5.73e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg03146154 chr1:46216737 IPP -0.51 -7.46 -0.38 7.41e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg15110403 chr19:17392923 ANKLE1 -0.54 -7.58 -0.38 3.54e-13 Systemic lupus erythematosus; LUSC trans rs6601327 0.641 rs11785923 chr8:9587674 G/C cg15556689 chr8:8085844 FLJ10661 -0.45 -6.4 -0.33 5.21e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg26659404 chr1:25747437 RHCE -0.27 -5.69 -0.3 2.74e-8 Erythrocyte sedimentation rate; LUSC cis rs951366 0.538 rs3761919 chr1:205694720 G/A cg07157834 chr1:205819609 PM20D1 -0.44 -5.85 -0.3 1.2e-8 Menarche (age at onset); LUSC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.62 7.85 0.39 5.67e-14 Lung function (FEV1/FVC); LUSC cis rs7264396 0.570 rs1970576 chr20:34336720 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.22 -0.45 3.35e-18 Total cholesterol levels; LUSC cis rs4704187 0.687 rs9293650 chr5:74497084 C/T cg03227963 chr5:74354835 NA 0.31 6.79 0.35 5.25e-11 Response to amphetamines; LUSC cis rs909002 0.925 rs4949455 chr1:32114793 C/T cg01639898 chr1:32083012 HCRTR1 0.24 5.68 0.3 2.86e-8 Intelligence (multi-trait analysis); LUSC cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg23583168 chr7:148888333 NA -0.9 -16.74 -0.68 4.08e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00850453 chr7:12726919 ARL4A -0.54 -6.71 -0.34 8.5e-11 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg25456477 chr12:86230367 RASSF9 0.35 6.16 0.32 2.14e-9 Major depressive disorder; LUSC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg03676636 chr4:99064102 C4orf37 0.37 8.14 0.41 7.81e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs4919087 0.892 rs10882881 chr10:99010067 T/A cg25902810 chr10:99078978 FRAT1 0.44 6.48 0.33 3.27e-10 Monocyte count; LUSC trans rs11700980 0.551 rs2832010 chr21:30110378 T/C cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC trans rs4689592 0.523 rs3857179 chr4:7070496 T/A cg07817883 chr1:32538562 TMEM39B -0.58 -6.75 -0.35 6.74e-11 Monocyte percentage of white cells; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg00945038 chr17:61921165 SMARCD2 0.53 9.27 0.45 2.34e-18 Prudent dietary pattern; LUSC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg25838465 chr1:92012736 NA -0.74 -15.09 -0.64 1.31e-39 Breast cancer; LUSC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg18758796 chr5:131593413 PDLIM4 0.4 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs6725517 0.737 rs7576788 chr2:25083310 A/G cg04586622 chr2:25135609 ADCY3 0.3 6.24 0.32 1.36e-9 Breast cancer; LUSC cis rs11030122 0.702 rs12286710 chr11:3967171 T/G cg18678763 chr11:4115507 RRM1 -0.47 -6.13 -0.32 2.47e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg26958806 chr6:27640298 NA 0.61 5.73 0.3 2.3e-8 Breast cancer; LUSC cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg05294307 chr14:35346193 BAZ1A -0.49 -6.21 -0.32 1.61e-9 Psoriasis; LUSC cis rs734999 0.545 rs12752515 chr1:2564465 T/C cg18932078 chr1:2524107 MMEL1 -0.31 -6.89 -0.35 2.79e-11 Ulcerative colitis; LUSC cis rs10208940 0.920 rs11894861 chr2:68706723 C/G cg12452813 chr2:68675892 NA 0.55 5.79 0.3 1.66e-8 Urate levels in lean individuals; LUSC cis rs80130819 0.748 rs2258342 chr12:48690363 T/C cg24011408 chr12:48396354 COL2A1 0.46 5.88 0.31 9.77e-9 Prostate cancer; LUSC trans rs3857536 0.740 rs7766407 chr6:66885658 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.22 -0.32 1.47e-9 Blood trace element (Cu levels); LUSC cis rs6459804 1.000 rs6459804 chr7:157510195 C/T cg05731713 chr7:157510257 PTPRN2 0.47 9.11 0.45 8.03e-18 Bipolar disorder and schizophrenia; LUSC cis rs34375054 0.672 rs10400509 chr12:125592173 T/C cg25124228 chr12:125621409 AACS -0.48 -7.62 -0.38 2.62e-13 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7937682 1.000 rs11608149 chr11:111535102 G/A cg19812747 chr11:111475976 SIK2 0.5 6.89 0.35 2.87e-11 Primary sclerosing cholangitis; LUSC cis rs11122272 0.668 rs1538664 chr1:231555295 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.28 -0.49 9.99e-22 Hemoglobin concentration; LUSC trans rs4689592 0.523 rs6446565 chr4:7074027 A/G cg07817883 chr1:32538562 TMEM39B -0.55 -6.44 -0.33 4.21e-10 Monocyte percentage of white cells; LUSC cis rs734999 0.545 rs6698817 chr1:2564183 T/C cg18854424 chr1:2615690 NA -0.49 -9.94 -0.48 1.48e-20 Ulcerative colitis; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg18402987 chr7:1209562 NA 0.71 7.53 0.38 4.64e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7312933 0.533 rs17551006 chr12:42848738 G/C cg01256987 chr12:42539512 GXYLT1 -0.38 -6.92 -0.35 2.26e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg22834771 chr12:69754056 YEATS4 -0.55 -8.13 -0.41 8.34e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs5747327 0.835 rs181396 chr22:18224155 A/G cg13083436 chr11:24518414 LUZP2 -0.33 -6.63 -0.34 1.37e-10 Myeloid white cell count;Granulocyte count; LUSC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg08975724 chr8:8085496 FLJ10661 0.49 7.57 0.38 3.56e-13 Mood instability; LUSC cis rs2969070 0.831 rs886627 chr7:2498054 C/T cg03277898 chr7:2518824 NA -0.29 -6.11 -0.32 2.85e-9 Diastolic blood pressure; LUSC cis rs6495122 0.501 rs6495151 chr15:75385990 A/G cg10253484 chr15:75165896 SCAMP2 0.42 5.96 0.31 6.25e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs1018836 0.669 rs6471243 chr8:91656967 C/T cg16814680 chr8:91681699 NA 1.03 22.6 0.78 2.7e-69 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.39e-13 Bipolar disorder; LUSC cis rs7959452 0.640 rs4761233 chr12:69722880 T/C cg14784868 chr12:69753453 YEATS4 0.63 9.39 0.46 9.5e-19 Blood protein levels; LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.46 -9.9 -0.48 1.96e-20 Autism spectrum disorder or schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg22372815 chr12:71833833 LGR5 0.68 6.6 0.34 1.62e-10 Cognitive performance; LUSC cis rs3818285 1.000 rs3818285 chr10:111635212 T/C cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.46 -0.38 7.45e-13 Superior crus of antihelix expression; LUSC cis rs72781680 0.898 rs72782113 chr2:24024952 G/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg06618935 chr21:46677482 NA -0.36 -7.23 -0.37 3.33e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10875746 0.903 rs61918774 chr12:48448134 C/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs11051970 0.704 rs2733694 chr12:32555230 A/G cg02745156 chr12:32552066 NA 0.37 6.81 0.35 4.48e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7043114 0.525 rs6479417 chr9:95064562 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.46 -0.33 3.63e-10 Height; LUSC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg06544989 chr22:39130855 UNC84B 0.37 6.41 0.33 5.04e-10 Menopause (age at onset); LUSC cis rs4654899 0.865 rs4654891 chr1:21286391 T/C cg01072550 chr1:21505969 NA -0.49 -7.28 -0.37 2.44e-12 Superior frontal gyrus grey matter volume; LUSC trans rs853679 0.607 rs67340775 chr6:28304384 A/C cg01620082 chr3:125678407 NA -0.85 -7.4 -0.38 1.09e-12 Depression; LUSC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg12257692 chr3:49977190 RBM6 0.25 6.92 0.35 2.29e-11 Intelligence (multi-trait analysis); LUSC cis rs80130819 0.515 rs917055 chr12:48385576 A/G cg24011408 chr12:48396354 COL2A1 0.54 6.76 0.35 6.01e-11 Prostate cancer; LUSC cis rs59698941 0.943 rs4705873 chr5:132267167 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17891123 chr15:90931113 IQGAP1 -0.48 -6.34 -0.33 7.5e-10 Hepatitis; LUSC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.29e-11 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg24846343 chr22:24311635 DDTL -0.62 -13.16 -0.58 3.77e-32 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7589342 0.517 rs6736701 chr2:106390440 G/T cg14210321 chr2:106509881 NCK2 -0.41 -5.83 -0.3 1.29e-8 Addiction; LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg27535305 chr1:53392650 SCP2 0.37 6.8 0.35 4.85e-11 Monocyte count; LUSC cis rs56804039 0.895 rs11776995 chr8:8385547 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -6.5 -0.34 2.89e-10 Cervical cancer; LUSC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg27532560 chr4:187881888 NA -0.39 -6.39 -0.33 5.65e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611519 0.929 rs9611466 chr22:41426299 A/T cg13813247 chr22:41461852 NA -0.37 -6.68 -0.34 9.83e-11 Neuroticism; LUSC cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.54 0.5 1.28e-22 Schizophrenia; LUSC cis rs7107174 1.000 rs11237480 chr11:78110385 C/A cg02023728 chr11:77925099 USP35 0.45 6.75 0.35 6.37e-11 Testicular germ cell tumor; LUSC cis rs35146811 0.625 rs2906645 chr7:99817859 A/G cg13334819 chr7:99746414 C7orf59 0.49 6.5 0.34 2.96e-10 Coronary artery disease; LUSC cis rs2219968 0.828 rs12545997 chr8:78910679 C/A cg00738934 chr8:78996279 NA -0.4 -7.2 -0.37 3.91e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg02931644 chr1:25747376 RHCE 0.33 5.99 0.31 5.39e-9 Erythrocyte sedimentation rate; LUSC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg00255919 chr5:131827918 IRF1 0.44 8.6 0.43 3.04e-16 Asthma (sex interaction); LUSC cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.03 -0.44 1.43e-17 Monocyte percentage of white cells; LUSC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg24060327 chr5:131705240 SLC22A5 -0.39 -6.31 -0.33 8.73e-10 Blood metabolite levels; LUSC cis rs6940638 0.688 rs2022272 chr6:27103580 A/G cg12826209 chr6:26865740 GUSBL1 0.54 7.78 0.39 9e-14 Intelligence (multi-trait analysis); LUSC cis rs826838 0.651 rs1843896 chr12:38612913 G/C cg13010199 chr12:38710504 ALG10B 0.59 8.84 0.44 5.46e-17 Heart rate; LUSC trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg15704280 chr7:45808275 SEPT13 0.77 8.48 0.42 7.41e-16 Axial length; LUSC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg03806693 chr22:41940476 POLR3H 0.97 14.06 0.61 1.34e-35 Vitiligo; LUSC cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg23711669 chr6:146136114 FBXO30 -0.79 -13.85 -0.6 8.76e-35 Lobe attachment (rater-scored or self-reported); LUSC trans rs34421088 0.532 rs2409754 chr8:11155613 A/G cg15556689 chr8:8085844 FLJ10661 0.41 6.08 0.32 3.24e-9 Neuroticism; LUSC cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg26587870 chr6:27730563 NA -0.61 -5.79 -0.3 1.62e-8 Breast cancer; LUSC trans rs208520 0.690 rs1304672 chr6:66847973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.88 0.58 4.26e-31 Exhaled nitric oxide output; LUSC trans rs877282 0.853 rs11253332 chr10:755262 G/C cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg24642439 chr20:33292090 TP53INP2 0.47 7.08 0.36 8.53e-12 Glomerular filtration rate (creatinine); LUSC cis rs72634258 0.842 rs7545677 chr1:8165619 C/T cg26816564 chr1:7831052 VAMP3 0.43 5.88 0.31 9.7e-9 Inflammatory bowel disease; LUSC cis rs12980942 1.000 rs7245398 chr19:41810644 A/G cg25627403 chr19:41769009 HNRNPUL1 0.57 6.18 0.32 1.91e-9 Coronary artery disease; LUSC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg06212747 chr3:49208901 KLHDC8B -0.47 -5.99 -0.31 5.36e-9 Parkinson's disease; LUSC cis rs524023 0.957 rs893006 chr11:64365796 C/A cg19131476 chr11:64387923 NRXN2 -0.39 -10.58 -0.5 9.15e-23 Urate levels in obese individuals; LUSC cis rs2404602 0.735 rs1607017 chr15:76726465 G/T cg23625390 chr15:77176239 SCAPER -0.62 -9.58 -0.46 2.34e-19 Blood metabolite levels; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9905704 0.918 rs11657676 chr17:56842043 A/G cg12560992 chr17:57184187 TRIM37 0.55 7.84 0.39 6.19e-14 Testicular germ cell tumor; LUSC cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg23933602 chr10:16859644 RSU1 0.58 6.85 0.35 3.46e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs9644630 0.930 rs6586839 chr8:19365543 A/T cg01280390 chr8:19363452 CSGALNACT1 -0.36 -6.76 -0.35 6.18e-11 Oropharynx cancer; LUSC cis rs422249 0.504 rs174538 chr11:61560081 G/A cg19610905 chr11:61596333 FADS2 -0.54 -8.02 -0.4 1.82e-14 Trans fatty acid levels; LUSC cis rs13315871 1.000 rs36037390 chr3:58321954 C/T cg20936604 chr3:58311152 NA -0.76 -7.26 -0.37 2.66e-12 Cholesterol, total; LUSC cis rs796364 0.760 rs74993507 chr2:201068684 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -7.96 -0.4 2.71e-14 Schizophrenia; LUSC cis rs11758351 0.518 rs78871852 chr6:26221566 A/T cg01420254 chr6:26195488 NA 0.65 7.28 0.37 2.44e-12 Gout;Renal underexcretion gout; LUSC cis rs17270561 0.636 rs6456694 chr6:25712894 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 7.84 0.39 6.23e-14 Iron status biomarkers; LUSC cis rs4363385 0.747 rs3737867 chr1:152976474 A/C cg00922841 chr1:152955080 SPRR1A -0.35 -5.89 -0.31 9.18e-9 Inflammatory skin disease; LUSC trans rs7829975 0.606 rs7819827 chr8:8797055 G/C cg21775007 chr8:11205619 TDH -0.41 -6.22 -0.32 1.49e-9 Mood instability; LUSC cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg15468180 chr1:107600409 PRMT6 0.38 6.14 0.32 2.34e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg15147215 chr3:52552868 STAB1 -0.31 -6.21 -0.32 1.6e-9 Electroencephalogram traits; LUSC trans rs7824557 0.579 rs10098322 chr8:11196295 C/G cg15556689 chr8:8085844 FLJ10661 0.44 6.85 0.35 3.61e-11 Retinal vascular caliber; LUSC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg15848620 chr12:58087721 OS9 0.45 5.73 0.3 2.23e-8 Multiple sclerosis; LUSC cis rs11214589 0.806 rs4551806 chr11:113250540 T/A cg14159747 chr11:113255604 NA 0.3 7.56 0.38 3.93e-13 Neuroticism; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg07092213 chr7:1199455 ZFAND2A -0.54 -8.33 -0.41 2.15e-15 Longevity;Endometriosis; LUSC cis rs7607369 0.574 rs12990478 chr2:219667463 T/A cg02176678 chr2:219576539 TTLL4 -0.52 -9.12 -0.45 7.46e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg18876405 chr7:65276391 NA 0.68 12.02 0.55 6.86e-28 Aortic root size; LUSC cis rs9399135 0.967 rs2327578 chr6:135329969 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Red blood cell count; LUSC trans rs62238980 0.614 rs78078590 chr22:32370487 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17739459 chr12:53835901 PRR13 0.44 6.17 0.32 1.93e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.82e-13 Motion sickness; LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg01879757 chr17:41196368 BRCA1 -0.47 -7.21 -0.37 3.83e-12 Menopause (age at onset); LUSC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg18876405 chr7:65276391 NA 0.75 13.73 0.6 2.53e-34 Aortic root size; LUSC cis rs2050392 0.590 rs303433 chr10:30714963 A/T cg18806716 chr10:30721971 MAP3K8 -0.69 -10.73 -0.51 2.89e-23 Inflammatory bowel disease; LUSC trans rs34421088 0.560 rs2248316 chr8:11397073 A/C cg15556689 chr8:8085844 FLJ10661 -0.6 -9.41 -0.46 8.23e-19 Neuroticism; LUSC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.53 -9.5 -0.46 4.14e-19 Menopause (age at onset); LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg00149659 chr3:10157352 C3orf10 0.88 12.38 0.56 3.02e-29 Alzheimer's disease; LUSC trans rs79976124 0.837 rs10944858 chr6:66646039 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.81 0.43 7.1e-17 Type 2 diabetes; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg03929089 chr4:120376271 NA -0.93 -16.14 -0.66 9.76e-44 Height; LUSC cis rs11018904 0.906 rs17227345 chr11:89954685 A/T cg26138821 chr11:89956704 CHORDC1 0.57 6.87 0.35 3.22e-11 Intelligence (multi-trait analysis); LUSC cis rs6845621 0.901 rs11723047 chr4:18923910 C/T cg12196642 chr4:18937545 NA -0.36 -6.66 -0.34 1.12e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg07606381 chr6:8435919 SLC35B3 0.75 12.72 0.57 1.74e-30 Motion sickness; LUSC cis rs11785400 0.793 rs2280879 chr8:143722228 T/C cg10596483 chr8:143751796 JRK 0.52 7.54 0.38 4.41e-13 Schizophrenia; LUSC trans rs8072100 0.905 rs8077106 chr17:45653291 T/G cg03886242 chr7:26192032 NFE2L3 0.38 6.32 0.33 8.36e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg05064044 chr6:292385 DUSP22 -0.53 -7.79 -0.39 8.49e-14 Menopause (age at onset); LUSC cis rs16854884 0.586 rs11914731 chr3:143725594 A/G cg01302019 chr3:143689584 C3orf58 -0.34 -5.65 -0.3 3.46e-8 Economic and political preferences (feminism/equality); LUSC cis rs10782582 0.593 rs12131493 chr1:76139172 G/A cg10523679 chr1:76189770 ACADM -0.5 -7.29 -0.37 2.31e-12 Daytime sleep phenotypes; LUSC cis rs500891 1.000 rs13201274 chr6:84176481 G/A cg08257003 chr6:84140564 ME1 0.34 7.12 0.36 6.55e-12 Platelet-derived growth factor BB levels; LUSC cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg13256891 chr4:100009986 ADH5 -0.47 -6.63 -0.34 1.38e-10 Smoking initiation; LUSC trans rs6480314 0.542 rs4592311 chr10:70028249 C/T cg04882175 chr6:131122610 NA -0.54 -6.32 -0.33 8.24e-10 Optic nerve measurement (disc area); LUSC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg05347473 chr6:146136440 FBXO30 -0.64 -11.01 -0.52 2.85e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg21724239 chr8:58056113 NA 0.57 6.58 0.34 1.87e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg08219700 chr8:58056026 NA 0.5 6.2 0.32 1.67e-9 Developmental language disorder (linguistic errors); LUSC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg01448562 chr3:133502909 NA -0.54 -7.94 -0.4 3.16e-14 Iron status biomarkers; LUSC trans rs6951245 1.000 rs78185558 chr7:1090183 G/C cg13565492 chr6:43139072 SRF -0.57 -6.11 -0.32 2.78e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs61931739 0.500 rs7311284 chr12:34478477 C/G cg06521331 chr12:34319734 NA -0.41 -6.43 -0.33 4.4e-10 Morning vs. evening chronotype; LUSC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg21138405 chr5:131827807 IRF1 0.35 6.22 0.32 1.45e-9 Breast cancer;Mosquito bite size; LUSC cis rs477692 0.569 rs10764886 chr10:131310680 C/T cg05714579 chr10:131428358 MGMT 0.42 5.96 0.31 6.43e-9 Response to temozolomide; LUSC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.73 0.35 7.39e-11 Intelligence (multi-trait analysis); LUSC cis rs12476592 0.714 rs262491 chr2:63841113 A/G cg10828910 chr2:63850056 LOC388955 0.51 5.95 0.31 6.95e-9 Childhood ear infection; LUSC trans rs10822407 0.710 rs10996078 chr10:66640749 C/T cg26654559 chr16:86492912 NA 0.34 6.06 0.31 3.63e-9 Diastolic blood pressure; LUSC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg06453172 chr10:134556979 INPP5A -0.51 -6.22 -0.32 1.5e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01763057 chr2:239112731 ILKAP -0.39 -6.05 -0.31 3.92e-9 Hepatitis; LUSC cis rs861020 0.959 rs658860 chr1:209990549 C/T cg05527609 chr1:210001259 C1orf107 0.93 11.98 0.55 9.53e-28 Orofacial clefts; LUSC cis rs2282300 0.739 rs35883696 chr11:30246407 A/C cg06241208 chr11:30344200 C11orf46 -0.44 -5.65 -0.3 3.52e-8 Morning vs. evening chronotype; LUSC cis rs10782582 0.609 rs5745347 chr1:76274520 C/T cg03433033 chr1:76189801 ACADM 0.42 6.28 0.33 1.05e-9 Daytime sleep phenotypes; LUSC cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg11102782 chr19:18549136 ISYNA1 -0.34 -6.52 -0.34 2.61e-10 Breast cancer; LUSC cis rs9902453 0.904 rs11654983 chr17:28370042 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.53 -0.5 1.46e-22 Coffee consumption (cups per day); LUSC cis rs7107174 1.000 rs1485483 chr11:77930138 T/C cg02023728 chr11:77925099 USP35 0.52 7.07 0.36 8.94e-12 Testicular germ cell tumor; LUSC cis rs7508679 1.000 rs10410204 chr19:7224350 C/T cg09779027 chr19:7224513 INSR 0.43 9.13 0.45 6.5e-18 Hypothyroidism; LUSC cis rs9300255 0.602 rs1716164 chr12:123663660 G/A cg00376283 chr12:123451042 ABCB9 0.65 8.16 0.41 7.13e-15 Neutrophil percentage of white cells; LUSC cis rs17095355 1.000 rs1376111 chr10:111707255 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.62 -0.38 2.6e-13 Biliary atresia; LUSC cis rs2204008 0.694 rs10880262 chr12:38328696 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.14 0.41 7.97e-15 Bladder cancer; LUSC cis rs10186029 0.509 rs2371793 chr2:213945082 G/C cg08319019 chr2:214017104 IKZF2 -0.44 -6.46 -0.33 3.67e-10 Systemic sclerosis; LUSC cis rs10392 0.543 rs4810245 chr20:37549309 G/A cg27552599 chr20:37590471 DHX35 0.43 6.84 0.35 3.77e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs1005277 0.602 rs1780141 chr10:38504299 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.5 -0.46 4.09e-19 Extrinsic epigenetic age acceleration; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.51 0.53 4.85e-26 Menopause (age at onset); LUSC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.16 15.5 0.65 3.26e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6545883 0.894 rs778157 chr2:61554289 C/G cg15711740 chr2:61764176 XPO1 -0.41 -6.43 -0.33 4.41e-10 Tuberculosis; LUSC cis rs7909074 1.000 rs10751360 chr10:45396971 G/A cg04218760 chr10:45406644 TMEM72 -0.3 -7.24 -0.37 3.16e-12 Mean corpuscular volume; LUSC cis rs6977660 1.000 rs13237667 chr7:19820288 G/C cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs7584330 0.780 rs12474519 chr2:238377012 G/A cg16989719 chr2:238392110 NA -0.37 -6.31 -0.33 8.83e-10 Prostate cancer; LUSC cis rs1797081 0.967 rs811912 chr10:16859618 G/C cg23933602 chr10:16859644 RSU1 1.09 25.68 0.81 4.5e-81 Platelet distribution width; LUSC cis rs1227969 0.706 rs1665581 chr10:71262048 G/T cg12610070 chr10:71211762 TSPAN15 -0.3 -6.74 -0.35 6.86e-11 Response to taxane treatment (placlitaxel); LUSC cis rs354225 0.584 rs6706263 chr2:54815240 C/T cg01766943 chr2:54829624 SPTBN1 0.5 8.16 0.41 7.07e-15 Schizophrenia; LUSC cis rs4891159 0.548 rs660342 chr18:74130896 C/G cg24786174 chr18:74118243 ZNF516 0.96 21.5 0.76 5.45e-65 Longevity; LUSC cis rs1949733 0.877 rs940133 chr4:8473614 T/C cg11789530 chr4:8429930 ACOX3 0.62 9.4 0.46 8.9e-19 Response to antineoplastic agents; LUSC cis rs68170813 0.641 rs1978085 chr7:107095216 T/C cg02696742 chr7:106810147 HBP1 -0.67 -9.69 -0.47 9.63e-20 Coronary artery disease; LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg14004847 chr7:1930337 MAD1L1 -0.51 -7.66 -0.39 2.06e-13 Bipolar disorder and schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22776125 chr6:167041314 RPS6KA2 0.45 6.64 0.34 1.24e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4253772 0.530 rs28362161 chr22:46807439 C/T cg18190219 chr22:46762943 CELSR1 -0.6 -5.81 -0.3 1.46e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg22532475 chr10:104410764 TRIM8 -0.35 -7.71 -0.39 1.43e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs607541 0.850 rs2218309 chr15:45938661 A/G cg26924012 chr15:45694286 SPATA5L1 0.84 6.81 0.35 4.59e-11 Obesity-related traits; LUSC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg18876405 chr7:65276391 NA 0.56 8.88 0.44 4.18e-17 Aortic root size; LUSC cis rs911555 0.755 rs975892 chr14:103883349 A/T cg12935359 chr14:103987150 CKB -0.64 -10.56 -0.5 1.14e-22 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg09267113 chr7:98030324 BAIAP2L1 0.38 5.83 0.3 1.29e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs4700695 0.719 rs27082 chr5:65436152 A/C cg21114390 chr5:65439923 SFRS12 -0.61 -8.81 -0.43 7.04e-17 Facial morphology (factor 19); LUSC trans rs3942852 0.806 rs1503188 chr11:48117478 C/T cg15704280 chr7:45808275 SEPT13 -0.57 -7.1 -0.36 7.41e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg22166914 chr1:53195759 ZYG11B 0.57 9.31 0.45 1.81e-18 Monocyte count; LUSC cis rs17401966 0.838 rs61775885 chr1:10281445 T/C cg19773385 chr1:10388646 KIF1B -0.51 -8.52 -0.42 5.74e-16 Hepatocellular carcinoma; LUSC cis rs12421382 0.659 rs2165137 chr11:109381995 G/T cg27471124 chr11:109292789 C11orf87 0.41 7.22 0.37 3.44e-12 Schizophrenia; LUSC cis rs2797160 1.000 rs1739348 chr6:126014573 T/C cg05901451 chr6:126070800 HEY2 0.57 8.65 0.43 2.22e-16 Endometrial cancer; LUSC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.52 -0.34 2.6200000000000003e-10 Lung cancer; LUSC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg13395646 chr4:1353034 KIAA1530 -0.79 -13.0 -0.58 1.57e-31 Obesity-related traits; LUSC trans rs11098499 0.954 rs12506546 chr4:120301618 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.03 0.31 4.33e-9 Corneal astigmatism; LUSC cis rs1577917 0.958 rs12207374 chr6:86656645 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.46 -0.42 8.33e-16 Response to antipsychotic treatment; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07605469 chr12:113573757 RASAL1 -0.51 -6.91 -0.35 2.44e-11 Hepatitis; LUSC trans rs34421088 0.560 rs2618434 chr8:11398865 A/G cg06636001 chr8:8085503 FLJ10661 -0.6 -9.32 -0.45 1.64e-18 Neuroticism; LUSC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 6.12 0.32 2.58e-9 Schizophrenia; LUSC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg06481639 chr22:41940642 POLR3H 0.5 5.77 0.3 1.81e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9487051 1.000 rs13191948 chr6:109634599 C/T cg21918786 chr6:109611834 NA -0.41 -7.06 -0.36 9.88e-12 Reticulocyte fraction of red cells; LUSC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg18876405 chr7:65276391 NA -0.58 -9.38 -0.46 1.08e-18 Aortic root size; LUSC cis rs7666738 0.546 rs10025064 chr4:98914060 A/G cg05340658 chr4:99064831 C4orf37 0.57 8.81 0.43 7.13e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7123876 0.504 rs1157343 chr11:72429141 A/G cg04827223 chr11:72435913 ARAP1 0.67 11.17 0.52 8.2e-25 Body mass index; LUSC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg05738196 chr6:26577821 NA 0.49 7.19 0.37 4.34e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg23711669 chr6:146136114 FBXO30 0.9 16.97 0.68 5.1e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg15556689 chr8:8085844 FLJ10661 -0.56 -8.88 -0.44 4.16e-17 Neuroticism; LUSC cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg12011299 chr4:100065546 ADH4 0.61 9.71 0.47 8.65e-20 Alcohol dependence; LUSC cis rs1451375 0.617 rs10267323 chr7:50591424 A/G cg18232548 chr7:50535776 DDC 0.54 7.58 0.38 3.41e-13 Malaria; LUSC cis rs13006833 0.703 rs291427 chr2:191194059 C/T cg21644426 chr2:191273491 MFSD6 0.42 6.11 0.32 2.76e-9 Urinary metabolites; LUSC cis rs17818399 0.547 rs4952831 chr2:46761181 G/A cg02822958 chr2:46747628 ATP6V1E2 0.44 6.46 0.33 3.74e-10 Height; LUSC cis rs1577917 0.958 rs12215265 chr6:86443969 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.69e-11 Response to antipsychotic treatment; LUSC cis rs748404 0.697 rs491804 chr15:43560825 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.33 0.41 2.18e-15 Lung cancer; LUSC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg01849466 chr14:104193079 ZFYVE21 -0.55 -7.88 -0.4 4.53e-14 Reticulocyte count; LUSC cis rs9393777 0.720 rs35769282 chr6:26999908 G/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -5.82 -0.3 1.35e-8 Intelligence (multi-trait analysis); LUSC cis rs11208691 0.513 rs11208698 chr1:66131238 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 Lymphocyte percentage of white cells; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg22764044 chr5:178986830 RUFY1 0.62 11.37 0.53 1.48e-25 Lung cancer; LUSC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg09699651 chr6:150184138 LRP11 0.37 5.75 0.3 2.02e-8 Lung cancer; LUSC cis rs9807989 0.507 rs6543133 chr2:103040177 A/T cg03938978 chr2:103052716 IL18RAP 0.37 7.04 0.36 1.12e-11 Asthma; LUSC cis rs78579285 0.584 rs9930994 chr16:88800693 C/T cg01900006 chr16:88814613 FAM38A 0.61 6.83 0.35 4.14e-11 Joint mobility (Beighton score); LUSC cis rs9486719 1.000 rs2472889 chr6:96866803 T/G cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg16928487 chr17:17741425 SREBF1 0.45 8.88 0.44 4.18e-17 Total body bone mineral density; LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 22.69 0.78 1.3e-69 Prudent dietary pattern; LUSC trans rs7980799 0.682 rs1601007 chr12:33609675 C/G cg13010199 chr12:38710504 ALG10B 0.42 6.17 0.32 1.99e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs4363385 0.747 rs4845506 chr1:152968407 G/A cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 3.97e-14 Inflammatory skin disease; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg25428297 chr7:1022841 CYP2W1 0.28 5.77 0.3 1.85e-8 Longevity;Endometriosis; LUSC cis rs427941 0.632 rs201469 chr7:101743932 C/G cg06246474 chr7:101738831 CUX1 0.39 6.42 0.33 4.68e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg15605315 chr1:45957053 TESK2 0.46 7.54 0.38 4.34e-13 High light scatter reticulocyte count; LUSC cis rs6845621 0.774 rs1452556 chr4:18936647 A/G cg12196642 chr4:18937545 NA -0.36 -6.76 -0.35 6.14e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg20476274 chr7:133979776 SLC35B4 0.81 14.71 0.63 4.3e-38 Mean platelet volume; LUSC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg11062466 chr8:58055876 NA 0.67 7.63 0.39 2.4e-13 Developmental language disorder (linguistic errors); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg06949789 chr3:23958708 NKIRAS1;RPL15 -0.48 -6.32 -0.33 8.2e-10 Hepatitis; LUSC trans rs7170930 0.618 rs1513932 chr15:66537899 G/A cg06396762 chr16:3202609 NA -0.72 -5.97 -0.31 5.91e-9 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12346351 chr4:152330392 FAM160A1 0.42 6.01 0.31 4.96e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg02527881 chr3:46936655 PTH1R -0.39 -6.87 -0.35 3.2e-11 Colorectal cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22728534 chr2:87034800 CD8A -0.39 -5.95 -0.31 6.67e-9 Electrocardiographic conduction measures; LUSC cis rs4295623 0.559 rs2409836 chr8:11689228 T/G cg21775007 chr8:11205619 TDH 0.44 6.12 0.32 2.64e-9 Morning vs. evening chronotype; LUSC cis rs7572644 0.712 rs1911128 chr2:28279649 T/G cg27432699 chr2:27873401 GPN1 -0.54 -6.86 -0.35 3.44e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11048434 0.736 rs12833375 chr12:9112018 A/T cg23795048 chr12:9217529 LOC144571 0.34 6.01 0.31 4.82e-9 Sjögren's syndrome; LUSC trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg13615516 chr5:77269221 NA 0.39 6.62 0.34 1.39e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg15147215 chr3:52552868 STAB1 -0.3 -5.87 -0.31 1.03e-8 Electroencephalogram traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16676734 chr14:93582668 ITPK1 0.43 6.26 0.32 1.18e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22590775 chr19:49891494 CCDC155 0.56 7.32 0.37 1.92e-12 Multiple sclerosis; LUSC cis rs243505 1.000 rs243515 chr7:148426672 A/C cg09806900 chr7:148480153 CUL1 -0.47 -6.61 -0.34 1.51e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg24110177 chr3:50126178 RBM5 0.57 9.21 0.45 3.63e-18 Intelligence (multi-trait analysis); LUSC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg24296786 chr1:45957014 TESK2 0.48 7.36 0.37 1.45e-12 High light scatter reticulocyte count; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg24235997 chr7:105264584 ATXN7L1 -0.4 -6.57 -0.34 1.91e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs950169 0.724 rs11632668 chr15:84948687 T/C cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs62103177 0.525 rs8086024 chr18:77746623 A/G cg20368463 chr18:77673604 PQLC1 -0.64 -7.03 -0.36 1.13e-11 Opioid sensitivity; LUSC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg12463550 chr7:65579703 CRCP -0.5 -7.24 -0.37 3.2e-12 Aortic root size; LUSC cis rs9905704 0.647 rs2108435 chr17:57102133 T/C cg12560992 chr17:57184187 TRIM37 -0.64 -10.71 -0.51 3.44e-23 Testicular germ cell tumor; LUSC cis rs860295 0.627 rs11264410 chr1:155745349 G/A cg08949192 chr1:155289623 RUSC1;FDPS -0.34 -5.74 -0.3 2.07e-8 Body mass index; LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.79 -0.3 1.64e-8 Platelet count; LUSC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg22029157 chr1:209979665 IRF6 0.78 10.26 0.49 1.17e-21 Cleft lip with or without cleft palate; LUSC cis rs9943753 0.525 rs6606708 chr12:109833146 T/C cg19025524 chr12:109796872 NA -0.38 -6.98 -0.36 1.59e-11 HDL cholesterol; LUSC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg03433033 chr1:76189801 ACADM 0.76 12.55 0.57 7.15e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs56283067 0.886 rs2023311 chr6:44678306 A/T cg18551225 chr6:44695536 NA -0.45 -7.83 -0.39 6.63e-14 Total body bone mineral density; LUSC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.29 -0.41 2.82e-15 Mean platelet volume; LUSC trans rs561341 0.830 rs2301765 chr17:30202056 T/A cg20587970 chr11:113659929 NA 1.14 13.52 0.59 1.65e-33 Hip circumference adjusted for BMI; LUSC cis rs9486719 1.000 rs2472890 chr6:96867646 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs3008870 0.755 rs3736905 chr1:67392614 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.48 0.56 1.38e-29 Lymphocyte percentage of white cells; LUSC cis rs6831352 0.879 rs4699716 chr4:100066125 G/A cg12011299 chr4:100065546 ADH4 -0.72 -10.43 -0.5 3.12e-22 Alcohol dependence; LUSC cis rs765787 0.530 rs2554455 chr15:45521304 T/C cg25801113 chr15:45476975 SHF 0.35 7.15 0.36 5.6e-12 Uric acid levels; LUSC trans rs1376359 0.537 rs526349 chr1:103274737 A/G cg17154563 chr19:40477487 PSMC4 0.47 5.97 0.31 5.95e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.67 0.39 1.87e-13 Bipolar disorder; LUSC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.6 0.46 2.01e-19 Attention deficit hyperactivity disorder; LUSC cis rs7107174 1.000 rs731600 chr11:77963133 A/G cg02023728 chr11:77925099 USP35 0.46 7.0 0.36 1.43e-11 Testicular germ cell tumor; LUSC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.57 0.38 3.58e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg18512352 chr11:47633146 NA -0.47 -9.63 -0.47 1.58e-19 Subjective well-being; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg03461704 chr1:205818484 PM20D1 0.36 5.82 0.3 1.39e-8 Menarche (age at onset); LUSC cis rs62344088 1.000 rs6880143 chr5:137516 C/T cg22857025 chr5:266934 NA -1.03 -7.61 -0.38 2.76e-13 Asthma (childhood onset); LUSC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg20203395 chr5:56204925 C5orf35 -0.8 -10.74 -0.51 2.61e-23 Initial pursuit acceleration; LUSC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg00343986 chr7:65444356 GUSB 0.48 7.28 0.37 2.42e-12 Aortic root size; LUSC cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg26384229 chr12:38710491 ALG10B 0.86 14.7 0.63 4.43e-38 Bladder cancer; LUSC cis rs8013055 0.846 rs10151805 chr14:105974781 T/C cg19700328 chr14:106028568 NA -0.41 -6.94 -0.36 1.99e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs11098499 0.954 rs34858317 chr4:120387110 A/C cg24375607 chr4:120327624 NA 0.78 11.55 0.53 3.41e-26 Corneal astigmatism; LUSC cis rs6545883 0.895 rs2421192 chr2:61643631 T/C cg15711740 chr2:61764176 XPO1 0.44 6.66 0.34 1.13e-10 Tuberculosis; LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.71 0.54 9.35e-27 Alzheimer's disease; LUSC cis rs4776059 0.798 rs4776063 chr15:52904046 C/A cg24008177 chr15:52972085 KIAA1370 0.32 5.82 0.3 1.39e-8 Schizophrenia; LUSC cis rs4664304 0.772 rs6737904 chr2:160872526 G/C cg03641300 chr2:160917029 PLA2R1 -0.37 -5.99 -0.31 5.48e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7254114 0.686 rs3745681 chr19:11303943 A/G cg02815516 chr19:11306319 KANK2 -0.43 -9.13 -0.45 6.64e-18 Immature fraction of reticulocytes; LUSC cis rs11608355 0.538 rs7305165 chr12:109804222 G/A cg19025524 chr12:109796872 NA -0.42 -7.65 -0.39 2.11e-13 Neuroticism; LUSC cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg00631329 chr6:26305371 NA -0.45 -8.86 -0.44 4.68e-17 Educational attainment; LUSC cis rs977987 0.933 rs4888431 chr16:75500699 G/T cg04384234 chr16:75411784 CFDP1 -0.49 -8.11 -0.41 9.52e-15 Dupuytren's disease; LUSC cis rs12313068 0.709 rs73404675 chr12:110504102 G/A cg12870014 chr12:110450643 ANKRD13A 0.66 9.66 0.47 1.25e-19 Intelligence (multi-trait analysis); LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg14752429 chr2:26569594 GPR113;SELI 0.41 5.99 0.31 5.34e-9 Eotaxin levels; LUSC cis rs4746822 0.906 rs10762264 chr10:70976833 G/A cg14418922 chr10:70824840 NA -0.38 -6.29 -0.33 1.01e-9 Glycemic traits (pregnancy); LUSC trans rs3733585 0.699 rs6856127 chr4:9965443 T/C cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.13e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8099014 0.911 rs8098308 chr18:56130661 A/G cg12907477 chr18:56117327 MIR122 0.44 7.04 0.36 1.09e-11 Platelet count; LUSC cis rs1775715 0.644 rs2799022 chr10:32137198 C/T cg03015672 chr10:32216066 ARHGAP12 0.35 6.27 0.32 1.13e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs897080 0.515 rs1067368 chr2:44654889 C/T cg00619915 chr2:44497795 NA -0.43 -6.37 -0.33 6.39e-10 Height; LUSC cis rs9304742 0.540 rs10416138 chr19:53465152 C/T cg09915433 chr19:53449742 NA -0.44 -6.86 -0.35 3.41e-11 Psoriasis; LUSC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg24675056 chr1:15929824 NA 0.49 8.52 0.42 5.69e-16 Systolic blood pressure; LUSC cis rs870825 0.872 rs12506750 chr4:185571123 C/T cg04058563 chr4:185651563 MLF1IP 0.89 11.13 0.52 1.11e-24 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25572309 chr10:134145729 LRRC27 -0.4 -6.11 -0.32 2.81e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg06873352 chr17:61820015 STRADA 0.7 12.58 0.57 5.53e-30 Prudent dietary pattern; LUSC cis rs240764 0.658 rs7768210 chr6:101261494 C/T cg09795085 chr6:101329169 ASCC3 0.46 6.6 0.34 1.61e-10 Neuroticism; LUSC cis rs3782089 1.000 rs11602375 chr11:65296540 C/T cg11802864 chr11:65308245 LTBP3 0.84 5.81 0.3 1.45e-8 Height; LUSC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg21724239 chr8:58056113 NA 0.77 7.97 0.4 2.61e-14 Developmental language disorder (linguistic errors); LUSC cis rs908922 0.676 rs6587686 chr1:152528948 C/T cg20991723 chr1:152506922 NA 0.49 9.23 0.45 3.09e-18 Hair morphology; LUSC cis rs2073300 1.000 rs6114098 chr20:23444276 G/A cg09953122 chr20:23471693 CST8 -0.77 -6.62 -0.34 1.46e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4363385 0.626 rs10888531 chr1:153063406 T/C cg00922841 chr1:152955080 SPRR1A -0.35 -6.04 -0.31 4.02e-9 Inflammatory skin disease; LUSC trans rs61931739 0.890 rs1197560 chr12:34121447 G/C cg26384229 chr12:38710491 ALG10B 0.56 9.0 0.44 1.77e-17 Morning vs. evening chronotype; LUSC cis rs5769707 0.521 rs5770633 chr22:50062427 G/A cg10356904 chr22:49881777 NA -0.29 -5.78 -0.3 1.75e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4462272 0.503 rs11596076 chr10:101845434 A/G cg02250046 chr10:101825185 CPN1 -0.31 -5.74 -0.3 2.09e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23956071 chr17:4710044 PLD2 -0.47 -6.13 -0.32 2.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.2 0.49 1.94e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg26677194 chr12:130822605 PIWIL1 -0.59 -8.76 -0.43 9.77e-17 Menopause (age at onset); LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg03354898 chr7:1950403 MAD1L1 -0.43 -8.63 -0.43 2.55e-16 Bipolar disorder and schizophrenia; LUSC cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg11266682 chr4:10021025 SLC2A9 0.58 10.45 0.5 2.65e-22 Bone mineral density; LUSC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs10761482 0.769 rs10761483 chr10:62098398 T/A cg18175470 chr10:62150864 ANK3 -0.51 -7.32 -0.37 1.89e-12 Schizophrenia; LUSC cis rs7267979 1.000 rs13038834 chr20:25441433 C/T cg08601574 chr20:25228251 PYGB 0.41 6.29 0.33 1e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6500602 0.647 rs4785967 chr16:4523208 G/A cg08645402 chr16:4508243 NA 0.51 8.74 0.43 1.15e-16 Schizophrenia; LUSC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg21251018 chr6:28226885 NKAPL 0.32 6.12 0.32 2.65e-9 Cardiac Troponin-T levels; LUSC cis rs354225 0.544 rs10182538 chr2:54808251 T/A cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs7100689 0.646 rs4468295 chr10:82119276 C/G cg01528321 chr10:82214614 TSPAN14 0.87 13.17 0.58 3.37e-32 Post bronchodilator FEV1; LUSC cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 32.85 0.87 1.22e-106 Chronic sinus infection; LUSC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg03806693 chr22:41940476 POLR3H -0.96 -13.04 -0.58 1.08e-31 Vitiligo; LUSC cis rs9921338 0.886 rs3931015 chr16:11415639 G/A cg00044050 chr16:11439710 C16orf75 0.48 6.47 0.33 3.47e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1801251 1.000 rs6746294 chr2:233583050 C/G cg08000102 chr2:233561755 GIGYF2 -0.64 -10.28 -0.49 1.03e-21 Coronary artery disease; LUSC cis rs2050392 0.517 rs619864 chr10:30750950 A/G cg25182066 chr10:30743637 MAP3K8 0.45 6.85 0.35 3.47e-11 Inflammatory bowel disease; LUSC cis rs58235267 0.553 rs1025132 chr2:63360639 G/A cg17519650 chr2:63277830 OTX1 0.67 9.67 0.47 1.13e-19 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg08355456 chr11:67383691 NA 0.32 5.8 0.3 1.54e-8 Mean corpuscular volume; LUSC cis rs710216 0.917 rs2297977 chr1:43415288 G/T cg22176566 chr1:43424700 SLC2A1 0.43 5.69 0.3 2.8e-8 Red cell distribution width; LUSC cis rs9790314 0.846 rs899275 chr3:161042104 T/C cg03342759 chr3:160939853 NMD3 -0.57 -9.61 -0.47 1.88e-19 Morning vs. evening chronotype; LUSC cis rs1538970 0.884 rs781226 chr1:45872662 T/C cg05343316 chr1:45956843 TESK2 -0.58 -8.04 -0.4 1.54e-14 Platelet count; LUSC cis rs644799 0.710 rs10831429 chr11:95508524 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.12 0.58 5.41e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1348850 0.958 rs1405713 chr2:178461560 G/C cg22681709 chr2:178499509 PDE11A -0.47 -8.55 -0.42 4.39e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9399401 0.677 rs11155241 chr6:142664439 T/A cg03128060 chr6:142623767 GPR126 0.57 9.3 0.45 1.86e-18 Chronic obstructive pulmonary disease; LUSC cis rs11585357 0.947 rs6666990 chr1:17611520 G/A cg08277548 chr1:17600880 PADI3 0.63 6.8 0.35 4.74e-11 Hair shape; LUSC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs11030122 0.702 rs12223176 chr11:3982537 T/G cg08557956 chr11:4115526 RRM1 -0.46 -5.72 -0.3 2.39e-8 Mean platelet volume;Platelet distribution width; LUSC trans rs2204008 0.805 rs11179579 chr12:38213957 A/C cg06521331 chr12:34319734 NA -0.39 -6.12 -0.32 2.68e-9 Bladder cancer; LUSC cis rs6580649 0.771 rs1034762 chr12:48389643 G/T cg24011408 chr12:48396354 COL2A1 -0.5 -6.62 -0.34 1.4e-10 Lung cancer; LUSC cis rs7267979 0.565 rs3752273 chr20:25594783 A/T cg03522245 chr20:25566470 NINL -0.39 -6.1 -0.32 2.93e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7605827 0.930 rs2052435 chr2:15687306 A/T cg19274914 chr2:15703543 NA 0.45 8.43 0.42 1.02e-15 Educational attainment (years of education); LUSC cis rs9929218 0.817 rs3114402 chr16:68719607 C/T cg02972257 chr16:68554789 NA 0.43 5.71 0.3 2.48e-8 Colorectal cancer; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24006384 chr1:8021553 PARK7 0.39 6.11 0.32 2.85e-9 Asthma; LUSC cis rs7528419 0.895 rs1277930 chr1:109822143 G/A cg00908766 chr1:109817496 CELSR2 0.74 11.34 0.53 1.92e-25 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; LUSC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg17179660 chr6:151773299 C6orf211;RMND1 -0.48 -6.98 -0.36 1.63e-11 Menarche (age at onset); LUSC cis rs11190604 1.000 rs3750626 chr10:102266316 C/T cg23241863 chr10:102295624 HIF1AN 0.5 6.15 0.32 2.17e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg19077165 chr18:44547161 KATNAL2 0.39 5.96 0.31 6.51e-9 Personality dimensions; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25669900 chr5:133861733 PHF15 -0.45 -6.66 -0.34 1.16e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg26335602 chr6:28129616 ZNF389 0.46 6.06 0.31 3.64e-9 Depression; LUSC cis rs7605827 0.930 rs2241236 chr2:15655480 A/G cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs1882538 0.538 rs7783217 chr7:133104117 C/G cg10665199 chr7:133106180 EXOC4 -0.59 -8.31 -0.41 2.37e-15 Intelligence (multi-trait analysis); LUSC cis rs2667011 0.818 rs2715918 chr2:160833188 A/G cg06573604 chr2:160760825 LY75 -0.47 -6.04 -0.31 4.16e-9 Bilirubin levels; LUSC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.14 0.32 2.31e-9 Schizophrenia; LUSC cis rs11023332 0.832 rs10832289 chr11:14669496 A/T cg05501817 chr11:14380813 RRAS2 0.39 6.13 0.32 2.48e-9 Adiponectin levels;Vitamin D levels; LUSC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg13206674 chr6:150067644 NUP43 0.59 9.36 0.46 1.24e-18 Lung cancer; LUSC trans rs2898290 0.622 rs978803 chr8:11343475 C/T cg08975724 chr8:8085496 FLJ10661 0.44 6.75 0.35 6.44e-11 Systolic blood pressure; LUSC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg04362960 chr10:104952993 NT5C2 -0.6 -9.32 -0.45 1.65e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg15691649 chr6:25882328 NA -0.39 -6.36 -0.33 6.75e-10 Blood metabolite levels; LUSC cis rs2075165 0.901 rs7542045 chr1:156246473 G/C cg20302342 chr1:156215951 PAQR6 0.32 6.09 0.32 3.11e-9 Tonsillectomy; LUSC cis rs7586879 1.000 rs7586879 chr2:25116977 C/T cg15423357 chr2:25149977 NA 0.35 6.42 0.33 4.79e-10 Body mass index; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg17968037 chr7:100024898 ZCWPW1 -0.42 -6.01 -0.31 4.82e-9 Platelet count; LUSC trans rs7824557 0.591 rs2736283 chr8:11225910 A/G cg08975724 chr8:8085496 FLJ10661 -0.41 -5.97 -0.31 6.06e-9 Retinal vascular caliber; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13875899 chr6:5004148 RPP40 -0.45 -6.03 -0.31 4.38e-9 Hepatitis; LUSC cis rs11690935 0.550 rs62183801 chr2:172867475 G/A cg13550731 chr2:172543902 DYNC1I2 0.53 7.96 0.4 2.7e-14 Schizophrenia; LUSC cis rs7043114 0.525 rs7023004 chr9:95098712 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.95 -0.36 1.91e-11 Height; LUSC cis rs2245008 0.671 rs907036 chr16:83989850 A/T cg07978099 chr16:83986941 OSGIN1 0.56 9.13 0.45 6.69e-18 Pursuit maintenance gain; LUSC cis rs79839061 0.610 rs62297087 chr4:913289 T/A cg14530993 chr4:882597 GAK 0.66 6.9 0.35 2.68e-11 Intelligence (multi-trait analysis); LUSC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg18252515 chr7:66147081 NA -1.23 -13.28 -0.59 1.37e-32 Diabetic kidney disease; LUSC cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg13319975 chr6:146136371 FBXO30 0.47 7.09 0.36 8.06e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7250872 0.647 rs12976128 chr19:1817113 A/C cg02747822 chr19:1826707 REXO1 0.37 5.71 0.3 2.46e-8 Bipolar disorder; LUSC cis rs7177699 0.526 rs7182529 chr15:79123631 T/C cg15571903 chr15:79123663 NA 0.34 6.34 0.33 7.41e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.64 0.34 1.26e-10 Menopause (age at onset); LUSC cis rs4919694 1.000 rs79254677 chr10:104691567 A/G cg04362960 chr10:104952993 NT5C2 1.14 13.5 0.59 1.89e-33 Arsenic metabolism; LUSC cis rs7940866 0.809 rs11222410 chr11:130833994 A/G cg12179176 chr11:130786555 SNX19 0.63 9.68 0.47 1.05e-19 Schizophrenia; LUSC cis rs981844 0.778 rs55895613 chr4:154638121 G/T cg14289246 chr4:154710475 SFRP2 0.47 5.83 0.3 1.32e-8 Response to statins (LDL cholesterol change); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03768916 chr10:49813307 ARHGAP22 0.41 6.55 0.34 2.19e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs96067 0.772 rs6700737 chr1:36598214 A/G cg24686825 chr1:36642396 MAP7D1 -0.7 -9.32 -0.45 1.63e-18 Corneal structure; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.71 12.0 0.55 7.98e-28 Prudent dietary pattern; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13855674 chr2:32853033 TTC27 -0.46 -6.02 -0.31 4.53e-9 Hepatitis; LUSC cis rs1023500 0.573 rs133382 chr22:42471774 C/T cg15557168 chr22:42548783 NA -0.46 -7.01 -0.36 1.35e-11 Schizophrenia; LUSC cis rs6733011 0.506 rs11123755 chr2:99507948 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.4 -5.72 -0.3 2.32e-8 Bipolar disorder; LUSC cis rs400736 0.671 rs863171 chr1:7992615 A/G cg25007680 chr1:8021821 PARK7 0.49 7.32 0.37 1.89e-12 Response to antidepressants and depression; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg08677398 chr8:58056175 NA -0.56 -6.92 -0.35 2.32e-11 Developmental language disorder (linguistic errors); LUSC trans rs7980799 0.649 rs10772088 chr12:33663849 A/T cg13010199 chr12:38710504 ALG10B -0.43 -6.16 -0.32 2.04e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg24675056 chr1:15929824 NA 0.45 7.76 0.39 1.03e-13 Systolic blood pressure; LUSC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg11752832 chr7:134001865 SLC35B4 0.56 8.67 0.43 1.92e-16 Mean platelet volume; LUSC cis rs10193935 0.901 rs7601905 chr2:42494144 A/G cg27598129 chr2:42591480 NA -0.54 -7.45 -0.38 8.22e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg03929089 chr4:120376271 NA -0.88 -13.01 -0.58 1.4e-31 Coronary artery disease; LUSC cis rs9311676 0.632 rs62259772 chr3:58417416 C/T cg26110898 chr3:58419937 PDHB 0.4 6.4 0.33 5.22e-10 Systemic lupus erythematosus; LUSC cis rs7089973 0.584 rs6585300 chr10:116639889 A/C cg23260525 chr10:116636907 FAM160B1 0.48 10.32 0.49 7.38e-22 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg06238570 chr21:40685208 BRWD1 0.58 9.74 0.47 7.02e-20 Cognitive function; LUSC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg09455208 chr3:40491958 NA 0.58 9.98 0.48 1.06e-20 Renal cell carcinoma; LUSC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg02038168 chr22:39784481 NA -0.48 -7.78 -0.39 9.41e-14 Intelligence (multi-trait analysis); LUSC cis rs12200782 0.530 rs9379892 chr6:26582414 G/A cg11502198 chr6:26597334 ABT1 0.93 11.29 0.53 2.9e-25 Small cell lung carcinoma; LUSC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg11062466 chr8:58055876 NA 0.47 6.37 0.33 6.36e-10 Developmental language disorder (linguistic errors); LUSC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg18230493 chr5:56204884 C5orf35 -0.76 -12.46 -0.56 1.53e-29 Initial pursuit acceleration; LUSC cis rs77741769 0.569 rs10774572 chr12:121309561 A/G cg02419362 chr12:121203948 SPPL3 0.46 8.51 0.42 5.87e-16 Mean corpuscular volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04716446 chr5:79703937 ZFYVE16 0.47 6.69 0.34 9.46e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13082711 0.522 rs653886 chr3:27343549 C/T cg02860705 chr3:27208620 NA 0.47 8.47 0.42 8.01e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.53 0.62 2.14e-37 Platelet count; LUSC cis rs7927592 0.830 rs11228240 chr11:68218290 C/T cg20283391 chr11:68216788 NA -0.62 -8.56 -0.42 4.04e-16 Total body bone mineral density; LUSC cis rs7589342 0.801 rs13031068 chr2:106455021 A/G cg14210321 chr2:106509881 NCK2 -0.54 -8.07 -0.4 1.25e-14 Addiction; LUSC cis rs9611519 0.929 rs13055800 chr22:41440424 G/A cg03806693 chr22:41940476 POLR3H -0.54 -7.3 -0.37 2.11e-12 Neuroticism; LUSC cis rs7666738 0.546 rs11097591 chr4:98910173 G/A cg17366294 chr4:99064904 C4orf37 0.55 8.84 0.44 5.57e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg14440974 chr22:39074834 NA -0.39 -6.46 -0.33 3.67e-10 Menopause (age at onset); LUSC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg23711669 chr6:146136114 FBXO30 0.87 15.63 0.65 1.03e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs7267979 0.966 rs416745 chr20:25438868 T/C cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1577917 0.655 rs9444352 chr6:86257535 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.37 5.91 0.31 8.34e-9 Response to antipsychotic treatment; LUSC cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.59 0.34 1.72e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg24562669 chr7:97807699 LMTK2 0.34 6.02 0.31 4.55e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1728785 0.818 rs1069289 chr16:68585317 C/A cg02972257 chr16:68554789 NA -0.49 -6.35 -0.33 7.09e-10 Ulcerative colitis; LUSC cis rs727505 0.564 rs68107250 chr7:124870200 G/A cg23710748 chr7:124431027 NA -0.4 -6.79 -0.35 5.07e-11 Lewy body disease; LUSC cis rs6942756 1.000 rs9640854 chr7:128884057 A/T cg02491457 chr7:128862824 NA -0.52 -7.42 -0.38 9.94e-13 White matter hyperintensity burden; LUSC cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg15691649 chr6:25882328 NA -0.39 -6.32 -0.33 8.37e-10 Blood metabolite levels; LUSC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.49e-11 Schizophrenia; LUSC trans rs57046232 0.552 rs6085506 chr20:6326507 T/C cg17788362 chr6:86352627 SYNCRIP 0.45 6.23 0.32 1.38e-9 Colorectal cancer; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg27094323 chr7:1216898 NA -0.46 -7.9 -0.4 4.06e-14 Longevity;Endometriosis; LUSC cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg10978503 chr1:24200527 CNR2 -0.44 -9.94 -0.48 1.49e-20 Immature fraction of reticulocytes; LUSC cis rs7826238 0.524 rs2921055 chr8:8319342 C/A cg11608241 chr8:8085544 FLJ10661 0.42 6.18 0.32 1.82e-9 Systolic blood pressure; LUSC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg22907277 chr7:1156413 C7orf50 0.52 5.9 0.31 9.13e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7264396 0.635 rs6058351 chr20:34486093 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.71 -0.43 1.42e-16 Total cholesterol levels; LUSC cis rs9467711 0.606 rs9379859 chr6:26369549 C/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs4663866 0.901 rs35390666 chr2:239193578 C/T cg16914508 chr2:239161102 PER2 0.7 7.47 0.38 7.07e-13 Irritable bowel syndrome; LUSC cis rs1577917 0.771 rs12205013 chr6:86333029 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.76 -0.43 9.71e-17 Response to antipsychotic treatment; LUSC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg18512352 chr11:47633146 NA -0.48 -9.8 -0.47 4.44e-20 Subjective well-being; LUSC cis rs6500395 0.962 rs1564980 chr16:48651377 A/T cg04672837 chr16:48644449 N4BP1 0.49 7.19 0.37 4.22e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg02951883 chr7:2050386 MAD1L1 -0.47 -7.94 -0.4 3.02e-14 Bipolar disorder and schizophrenia; LUSC cis rs988712 0.705 rs11030099 chr11:27677583 C/A cg10635145 chr11:27742435 BDNF -0.46 -5.88 -0.31 9.87e-9 Obesity; LUSC cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.51e-15 Axial length; LUSC cis rs6964587 1.000 rs10234434 chr7:91673308 A/T cg22709100 chr7:91322751 NA 0.41 5.92 0.31 8.03e-9 Breast cancer; LUSC cis rs11240408 1 rs11240408 chr1:205264536 A/T cg21545522 chr1:205238299 TMCC2 -0.46 -8.67 -0.43 1.88e-16 Platelet count; LUSC cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg13319975 chr6:146136371 FBXO30 0.38 5.7 0.3 2.66e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.679 rs16921687 chr8:58053514 T/C cg08219700 chr8:58056026 NA 0.46 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); LUSC cis rs709400 0.628 rs1951392 chr14:103853367 T/G cg24130564 chr14:104152367 KLC1 -0.43 -6.0 -0.31 5.17e-9 Body mass index; LUSC cis rs9419702 0.538 rs9322837 chr10:133539229 G/A cg23460707 chr10:133558971 NA 0.36 6.17 0.32 2e-9 Survival in rectal cancer; LUSC cis rs472402 0.580 rs3733773 chr5:6652252 G/A cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.54 -7.77 -0.39 1.01e-13 Response to amphetamines; LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.42 0.38 9.97e-13 Bipolar disorder; LUSC cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg00033643 chr7:134001901 SLC35B4 0.45 6.84 0.35 3.84e-11 Mean platelet volume; LUSC cis rs9326248 0.581 rs4938331 chr11:116930682 C/A cg20608306 chr11:116969690 SIK3 0.37 6.8 0.35 4.86e-11 Blood protein levels; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg02353165 chr6:42928485 GNMT 0.68 11.84 0.54 3.07e-27 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs13040088 1.000 rs12480117 chr20:61558274 G/A cg23096297 chr20:61557774 DIDO1 0.85 11.33 0.53 2.19e-25 Menopause (age at onset); LUSC cis rs259282 0.605 rs34727912 chr19:33110058 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.63 9.38 0.46 1.05e-18 Schizophrenia; LUSC cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg05347473 chr6:146136440 FBXO30 0.54 9.16 0.45 5.52e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07770353 chr16:69782764 NOB1 -0.72 -6.2 -0.32 1.66e-9 Cognitive performance; LUSC cis rs888194 0.544 rs7316486 chr12:109849540 A/G cg19025524 chr12:109796872 NA -0.34 -5.71 -0.3 2.49e-8 Neuroticism; LUSC cis rs6547741 1.000 rs4665381 chr2:27757150 A/C cg27432699 chr2:27873401 GPN1 0.78 14.73 0.63 3.51e-38 Oral cavity cancer; LUSC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.11e-11 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg12463550 chr7:65579703 CRCP -0.48 -7.11 -0.36 7.13e-12 Aortic root size; LUSC cis rs13089785 1.000 rs17310322 chr3:123670721 T/C cg02558132 chr3:123411198 MYLK 0.34 5.8 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.76 -13.31 -0.59 1.01e-32 Total body bone mineral density; LUSC cis rs11031096 0.655 rs11031252 chr11:4211165 A/G cg18678763 chr11:4115507 RRM1 -0.44 -6.01 -0.31 4.94e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs477692 1.000 rs577227 chr10:131404528 C/T cg05714579 chr10:131428358 MGMT 0.51 7.43 0.38 9.46e-13 Response to temozolomide; LUSC cis rs2414856 0.510 rs72758937 chr15:64667930 T/C cg08069370 chr15:64387884 SNX1 -0.78 -6.58 -0.34 1.84e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs34779708 0.931 rs4934535 chr10:35432721 G/T cg03585969 chr10:35415529 CREM 0.6 8.79 0.43 8.31e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs807669 0.524 rs11089258 chr22:19162276 C/T cg02655711 chr22:19163373 SLC25A1 0.56 10.31 0.49 8.27e-22 Metabolite levels; LUSC cis rs698813 0.789 rs2592195 chr2:44607707 A/G cg00619915 chr2:44497795 NA -0.39 -5.66 -0.3 3.22e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.9 -0.44 3.51e-17 Intelligence (multi-trait analysis); LUSC cis rs2898681 0.618 rs79471207 chr4:53738524 C/T cg21521518 chr4:53727714 RASL11B 0.44 5.7 0.3 2.63e-8 Optic nerve measurement (cup area); LUSC cis rs68170813 0.559 rs79026644 chr7:107031803 A/G cg02696742 chr7:106810147 HBP1 -0.63 -9.11 -0.45 7.97e-18 Coronary artery disease; LUSC cis rs7572644 0.680 rs12623170 chr2:28020157 C/T cg27432699 chr2:27873401 GPN1 0.55 7.22 0.37 3.49e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6987853 0.787 rs1343874 chr8:42424746 C/T cg09913449 chr8:42400586 C8orf40 0.49 8.34 0.42 1.91e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs3824867 0.879 rs10742806 chr11:47456226 T/A cg20307385 chr11:47447363 PSMC3 0.66 9.74 0.47 6.62e-20 Mean corpuscular hemoglobin; LUSC cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.76 -0.51 2.19e-23 Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12040534 chr17:17942854 ATPAF2;C17orf39 0.44 6.11 0.32 2.77e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1044826 0.642 rs167187 chr3:139237008 C/T cg00490450 chr3:139108681 COPB2 -0.47 -7.19 -0.37 4.28e-12 Obesity-related traits; LUSC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg10909506 chr17:38081995 ORMDL3 0.33 5.85 0.3 1.17e-8 Self-reported allergy; LUSC cis rs9486719 1.000 rs13210597 chr6:96969694 C/A cg06623918 chr6:96969491 KIAA0776 -0.81 -10.04 -0.48 6.67e-21 Migraine;Coronary artery disease; LUSC cis rs4443100 0.631 rs13054904 chr22:23410918 A/T cg14186256 chr22:23484241 RTDR1 -0.55 -7.12 -0.36 6.53e-12 Serum parathyroid hormone levels; LUSC cis rs7705502 0.962 rs17696407 chr5:173387335 C/A cg18693985 chr5:173351052 CPEB4 -0.4 -6.26 -0.32 1.2e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1535500 1.000 rs1535500 chr6:39284050 G/T cg06347083 chr6:39282316 KCNK17 -0.28 -6.1 -0.32 2.99e-9 Type 2 diabetes; LUSC cis rs17685 0.725 rs6467993 chr7:75719350 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.04 -0.4 1.62e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg06544989 chr22:39130855 UNC84B 0.33 5.65 0.3 3.51e-8 Menopause (age at onset); LUSC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg09517075 chr8:22133004 PIWIL2 0.43 8.57 0.42 4e-16 Hypertriglyceridemia; LUSC cis rs10489525 0.502 rs12026930 chr1:115597836 G/A cg01522456 chr1:115632236 TSPAN2 0.47 6.88 0.35 2.92e-11 Autism; LUSC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg01097406 chr16:89675127 NA -0.35 -7.1 -0.36 7.44e-12 Vitiligo; LUSC cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.03 0.58 1.16e-31 Chronic sinus infection; LUSC trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs2730245 0.527 rs842707 chr7:158656012 C/T cg24397884 chr7:158709396 WDR60 0.77 8.55 0.42 4.52e-16 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13898548 chr5:176924827 PDLIM7 -0.35 -5.95 -0.31 6.83e-9 Electrocardiographic conduction measures; LUSC cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg08999081 chr20:33150536 PIGU 0.37 6.82 0.35 4.3e-11 Height; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg00149659 chr3:10157352 C3orf10 0.89 12.11 0.55 3.04e-28 Alzheimer's disease; LUSC cis rs11168618 0.810 rs6580671 chr12:48841057 G/A cg24011408 chr12:48396354 COL2A1 0.38 6.07 0.32 3.48e-9 Adiponectin levels; LUSC cis rs7615952 0.546 rs11711150 chr3:125315663 C/T cg05084668 chr3:125655381 ALG1L -0.47 -5.92 -0.31 8.2e-9 Blood pressure (smoking interaction); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg02361781 chr15:52043731 TMOD2;LYSMD2 0.46 6.05 0.31 3.92e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg00504896 chr12:9437009 LOC642846 -0.47 -7.73 -0.39 1.25e-13 Breast size; LUSC cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.44 -0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.54 0.38 4.59e-13 Bipolar disorder; LUSC cis rs10876993 0.928 rs1689596 chr12:58053029 T/C cg15848620 chr12:58087721 OS9 -0.55 -7.84 -0.39 6.28e-14 Celiac disease or Rheumatoid arthritis; LUSC trans rs28647808 0.881 rs28494844 chr9:136266188 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg27266060 chr8:22091797 NA 0.36 6.72 0.35 7.74e-11 Hypertriglyceridemia; LUSC cis rs7107174 1.000 rs10899476 chr11:78051794 A/G cg02023728 chr11:77925099 USP35 0.45 6.62 0.34 1.42e-10 Testicular germ cell tumor; LUSC cis rs12368653 0.840 rs10877020 chr12:58188014 G/A cg12615879 chr12:58013172 SLC26A10 0.27 6.43 0.33 4.48e-10 Multiple sclerosis; LUSC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg03690763 chr11:133734501 NA -0.33 -5.66 -0.3 3.21e-8 Childhood ear infection; LUSC trans rs11098499 0.863 rs1552095 chr4:120460306 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.42 0.33 4.61e-10 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13633754 chr9:95858523 C9orf89 -0.38 -6.01 -0.31 4.76e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10486158 0.843 rs1294621 chr7:7392688 C/T cg01895333 chr3:109035405 DPPA2 -0.37 -6.09 -0.32 3.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs7089973 0.604 rs2420069 chr10:116605103 A/G cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11671664 0.732 rs67775326 chr19:46160969 A/G cg13320842 chr19:46175254 GIPR 0.5 6.58 0.34 1.77e-10 Type 2 diabetes;Body mass index;Body mass index (SNP x SNP interaction); LUSC cis rs7131987 0.650 rs12366527 chr12:29474256 C/G cg09582351 chr12:29534625 ERGIC2 -0.33 -6.77 -0.35 5.69e-11 QT interval; LUSC cis rs4555082 1.000 rs4555082 chr14:105758964 C/T cg06808227 chr14:105710500 BRF1 -0.63 -9.69 -0.47 9.62e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg12292205 chr6:26970375 C6orf41 0.68 11.53 0.53 4.12e-26 Autism spectrum disorder or schizophrenia; LUSC cis rs981844 0.813 rs72731678 chr4:154671476 T/C cg14289246 chr4:154710475 SFRP2 0.51 6.57 0.34 1.98e-10 Response to statins (LDL cholesterol change); LUSC cis rs11711311 1.000 rs7633832 chr3:113472292 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.77 -0.3 1.78e-8 IgG glycosylation; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg07092213 chr7:1199455 ZFAND2A -0.41 -6.3 -0.33 9.2e-10 Longevity;Endometriosis; LUSC cis rs1535500 0.967 rs11756091 chr6:39282806 G/T cg06347083 chr6:39282316 KCNK17 -0.29 -6.27 -0.32 1.14e-9 Type 2 diabetes; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg26618056 chr16:25043323 NA 0.38 6.52 0.34 2.54e-10 Mosquito bite size; LUSC cis rs231513 0.911 rs124720 chr17:41960141 A/G cg26893861 chr17:41843967 DUSP3 -0.53 -5.84 -0.3 1.26e-8 Cognitive function; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.39 0.53 1.28e-25 Prudent dietary pattern; LUSC cis rs11971779 0.680 rs6467840 chr7:139065401 A/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs5758511 0.773 rs9623482 chr22:42360574 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.5 -6.12 -0.32 2.6e-9 Birth weight; LUSC cis rs9653442 0.545 rs4851257 chr2:100775297 C/T cg07810366 chr2:100720526 AFF3 -0.44 -7.51 -0.38 5.58e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs10832963 1.000 rs11024739 chr11:18645843 A/C cg20219074 chr11:18656078 SPTY2D1 -0.71 -10.48 -0.5 2.05e-22 Breast cancer; LUSC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg26162295 chr17:38119207 GSDMA 0.24 5.9 0.31 9.1e-9 Self-reported allergy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12876261 chr7:56119223 PSPH;CCT6A -0.54 -7.06 -0.36 9.97e-12 Bipolar disorder and schizophrenia; LUSC cis rs8027181 0.804 rs7178130 chr15:72978202 A/G cg25632853 chr15:73088954 NA -0.32 -6.45 -0.33 3.93e-10 Triglyceride levels; LUSC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6430585 0.527 rs62168833 chr2:136449254 G/A cg07169764 chr2:136633963 MCM6 1.05 14.07 0.61 1.21e-35 Corneal structure; LUSC trans rs61931739 0.782 rs1197569 chr12:34186733 A/T cg26384229 chr12:38710491 ALG10B 0.56 9.07 0.44 1.07e-17 Morning vs. evening chronotype; LUSC cis rs72634258 0.945 rs67717282 chr1:8041290 C/T cg00042356 chr1:8021962 PARK7 0.75 9.38 0.46 1.05e-18 Inflammatory bowel disease; LUSC cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg23649088 chr2:200775458 C2orf69 -0.57 -7.01 -0.36 1.33e-11 Schizophrenia; LUSC cis rs2996428 0.629 rs12135894 chr1:3728061 C/T cg23277830 chr1:3704460 LRRC47 0.35 6.66 0.34 1.11e-10 Red cell distribution width; LUSC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg06481639 chr22:41940642 POLR3H -0.51 -5.76 -0.3 1.86e-8 Vitiligo; LUSC cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.07e-12 Motion sickness; LUSC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs7189233 0.531 rs4281707 chr16:53501946 G/A cg09728985 chr16:53543985 NA -0.32 -5.96 -0.31 6.3e-9 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.08 -0.4 1.19e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC cis rs1215050 0.791 rs6532702 chr4:98766641 C/T cg05340658 chr4:99064831 C4orf37 0.43 6.6 0.34 1.64e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg10621924 chr7:39171070 POU6F2 0.48 7.36 0.37 1.49e-12 IgG glycosylation; LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg12564285 chr5:131593104 PDLIM4 -0.47 -8.04 -0.4 1.6e-14 Breast cancer; LUSC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg08999081 chr20:33150536 PIGU 0.51 10.22 0.49 1.58e-21 Glomerular filtration rate (creatinine); LUSC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11644478 chr21:40555479 PSMG1 -0.8 -14.41 -0.62 5.8e-37 Cognitive function; LUSC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg04369109 chr6:150039330 LATS1 -0.56 -8.21 -0.41 4.77e-15 Lung cancer; LUSC cis rs73206853 0.620 rs28720928 chr12:111126609 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.68 0.39 1.82e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9815354 0.812 rs73069213 chr3:41940590 G/A cg03022575 chr3:42003672 ULK4 0.82 8.61 0.43 3.02e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9393777 0.528 rs9467989 chr6:27064275 C/T cg12292205 chr6:26970375 C6orf41 -0.64 -9.14 -0.45 6.03e-18 Intelligence (multi-trait analysis); LUSC cis rs716595 0.581 rs12415370 chr10:112015221 C/T cg13996003 chr10:112034540 MXI1 -0.61 -7.22 -0.37 3.62e-12 Normalized brain volume; LUSC cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg24562669 chr7:97807699 LMTK2 0.47 8.39 0.42 1.38e-15 Breast cancer; LUSC cis rs16854884 0.632 rs4563409 chr3:143682122 T/G cg06585982 chr3:143692056 C3orf58 0.45 6.7 0.34 8.62e-11 Economic and political preferences (feminism/equality); LUSC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg23583168 chr7:148888333 NA 0.86 15.81 0.65 2e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg00908189 chr16:619842 PIGQ 0.67 10.41 0.5 3.54e-22 Height; LUSC cis rs9467773 1.000 rs12526680 chr6:26550954 A/G cg09904177 chr6:26538194 HMGN4 0.73 13.41 0.59 4.05e-33 Intelligence (multi-trait analysis); LUSC cis rs9309473 1.000 rs56672945 chr2:73622663 C/T cg20560298 chr2:73613845 ALMS1 -0.49 -6.83 -0.35 3.95e-11 Metabolite levels; LUSC cis rs11031096 0.502 rs720571 chr11:4001328 G/T cg18678763 chr11:4115507 RRM1 -0.45 -5.98 -0.31 5.65e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs11165623 0.792 rs9437607 chr1:96977788 G/A cg10631902 chr5:14652156 NA -0.45 -6.95 -0.36 1.96e-11 Hip circumference;Waist circumference; LUSC cis rs1506636 1.000 rs652497 chr7:123423671 G/T cg03229431 chr7:123269106 ASB15 0.65 10.68 0.5 4.29e-23 Plateletcrit;Platelet count; LUSC cis rs62244186 0.566 rs2135531 chr3:44881158 C/G cg21672276 chr3:44754072 ZNF502 -0.38 -5.77 -0.3 1.85e-8 Depressive symptoms; LUSC cis rs9467773 0.595 rs9366657 chr6:26434914 C/G cg09904177 chr6:26538194 HMGN4 0.59 9.12 0.45 7.16e-18 Intelligence (multi-trait analysis); LUSC cis rs72720396 0.789 rs10922910 chr1:91199862 G/T cg13456504 chr1:91191583 NA 0.57 8.23 0.41 4.23e-15 Morning vs. evening chronotype;Chronotype; LUSC cis rs7561273 0.586 rs11896092 chr2:24317827 G/A cg20701182 chr2:24300061 SF3B14 0.51 6.55 0.34 2.19e-10 Quantitative traits; LUSC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg02487422 chr3:49467188 NICN1 0.44 7.03 0.36 1.17e-11 Resting heart rate; LUSC cis rs540254 0.647 rs12405457 chr1:160759052 A/G cg20255094 chr1:160771763 LY9 0.55 6.54 0.34 2.25e-10 Blood protein levels; LUSC cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg18196295 chr10:418757 DIP2C 0.5 8.34 0.42 1.91e-15 Psychosis in Alzheimer's disease; LUSC cis rs7927771 0.524 rs11039419 chr11:47851354 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.52 0.34 2.68e-10 Subjective well-being; LUSC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg24399712 chr22:39784796 NA -0.62 -11.36 -0.53 1.66e-25 Intelligence (multi-trait analysis); LUSC cis rs12950390 0.853 rs8078052 chr17:45859434 A/G cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.45e-10 IgG glycosylation; LUSC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg17724175 chr1:150552817 MCL1 -0.44 -8.0 -0.4 2.13e-14 Urate levels; LUSC cis rs427394 0.796 rs274683 chr5:6747950 T/A cg10857441 chr5:6722123 POLS -0.36 -6.58 -0.34 1.81e-10 Menopause (age at onset); LUSC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.43 -0.42 1.08e-15 Height; LUSC cis rs2130392 1.000 rs873686 chr4:185638876 A/G cg21366198 chr4:185655624 MLF1IP 0.42 6.0 0.31 5.19e-9 Kawasaki disease; LUSC cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg13010199 chr12:38710504 ALG10B -0.68 -11.45 -0.53 8.21e-26 Heart rate; LUSC trans rs853679 0.545 rs35949109 chr6:28025926 T/C cg01620082 chr3:125678407 NA -0.69 -7.46 -0.38 7.76e-13 Depression; LUSC cis rs4704187 0.640 rs1600073 chr5:74436737 C/T cg03227963 chr5:74354835 NA 0.3 6.34 0.33 7.48e-10 Response to amphetamines; LUSC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.14 0.41 7.67e-15 Homoarginine levels; LUSC trans rs1973993 0.745 rs6686016 chr1:96948002 G/A cg10631902 chr5:14652156 NA -0.49 -7.37 -0.37 1.34e-12 Weight; LUSC cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg05985134 chr18:33552581 C18orf21 0.51 7.01 0.36 1.33e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.32e-23 Alcohol dependence; LUSC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg24549020 chr5:56110836 MAP3K1 0.49 5.67 0.3 3.12e-8 Initial pursuit acceleration; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.51 0.34 2.77e-10 Menopause (age at onset); LUSC cis rs2580764 0.678 rs2255112 chr2:55200800 T/G cg09592903 chr2:55203963 RTN4 0.48 9.97 0.48 1.17e-20 Mean platelet volume; LUSC cis rs2295359 0.892 rs4655687 chr1:67649946 C/T cg12940439 chr1:67600707 NA 0.37 6.01 0.31 4.96e-9 Psoriasis; LUSC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg16329197 chr12:53359506 NA -0.51 -7.23 -0.37 3.32e-12 Prostate cancer; LUSC cis rs4947962 0.585 rs57682440 chr7:55156075 G/A cg23757825 chr7:55092271 EGFR -0.46 -5.67 -0.3 3.08e-8 Subjective response to lithium treatment; LUSC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg03213289 chr20:61660250 NA 0.67 13.96 0.61 3.26e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs503341 0.756 rs612010 chr11:63591005 G/A cg04362095 chr11:63592001 C11orf84 -0.58 -8.9 -0.44 3.59e-17 Pulse pressure; LUSC cis rs9527 0.590 rs7912517 chr10:104905529 G/A cg05855489 chr10:104503620 C10orf26 0.52 8.02 0.4 1.81e-14 Arsenic metabolism; LUSC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs929596 0.574 rs75444879 chr2:234587848 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.47 -0.38 7.23e-13 Total bilirubin levels in HIV-1 infection; LUSC cis rs2115630 0.791 rs2008262 chr15:85305270 C/T cg09876464 chr15:85330779 ZNF592 0.37 6.73 0.35 7.22e-11 P wave terminal force; LUSC cis rs6693567 0.565 rs1260404 chr1:150304150 T/A cg15654264 chr1:150340011 RPRD2 0.44 7.02 0.36 1.22e-11 Migraine; LUSC cis rs2732480 0.500 rs7966829 chr12:48615603 G/T cg04545296 chr12:48745243 ZNF641 0.33 6.27 0.32 1.11e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7428496 0.528 rs6440085 chr3:142232743 A/T cg16271453 chr3:142027066 XRN1 -0.51 -8.95 -0.44 2.6e-17 Mean corpuscular hemoglobin; LUSC cis rs2075371 0.611 rs35428392 chr7:134019645 G/A cg11752832 chr7:134001865 SLC35B4 0.5 7.14 0.36 5.75e-12 Mean platelet volume; LUSC trans rs6982636 0.934 rs2954022 chr8:126482621 C/A cg13325919 chr3:181432053 SOX2;SOX2OT -0.33 -6.39 -0.33 5.59e-10 Lipid metabolism phenotypes; LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs6430585 0.528 rs75524146 chr2:136725459 C/T cg07169764 chr2:136633963 MCM6 1.13 17.44 0.69 6.81e-49 Corneal structure; LUSC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.55 -0.42 4.48e-16 Personality dimensions; LUSC cis rs13315871 0.929 rs17059171 chr3:58302586 A/G cg12435725 chr3:58293450 RPP14 -0.68 -7.11 -0.36 6.88e-12 Cholesterol, total; LUSC trans rs2243480 1.000 rs2177703 chr7:65391717 C/A cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC trans rs11992162 0.591 rs34123222 chr8:11795349 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.41 -0.33 4.9e-10 Monocyte count; LUSC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg20203395 chr5:56204925 C5orf35 -0.62 -7.99 -0.4 2.23e-14 Initial pursuit acceleration; LUSC cis rs1577917 0.958 rs12209668 chr6:86566517 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg11189052 chr15:85197271 WDR73 0.49 6.3 0.33 9.15e-10 Schizophrenia; LUSC cis rs11608355 0.545 rs11615949 chr12:109894347 G/A cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg22823121 chr1:150693482 HORMAD1 -0.54 -7.82 -0.39 7.11e-14 Blood protein levels; LUSC trans rs35110281 0.667 rs9941787 chr21:45116042 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.63 0.5 6.54e-23 Mean corpuscular volume; LUSC cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg11266682 chr4:10021025 SLC2A9 0.55 10.06 0.48 5.64e-21 Bone mineral density; LUSC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg00784671 chr22:46762841 CELSR1 -0.63 -7.02 -0.36 1.27e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs4660306 0.961 rs4660871 chr1:45995232 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -7.01 -0.36 1.29e-11 Homocysteine levels; LUSC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.11 -0.32 2.82e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg00339695 chr16:24857497 SLC5A11 0.6 8.76 0.43 9.9900000000000006e-17 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05397629 chr11:3848986 RHOG 0.46 6.0 0.31 5.1e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg27170947 chr2:26402098 FAM59B 0.61 8.46 0.42 8.73e-16 Gut microbiome composition (summer); LUSC cis rs1348850 0.757 rs4893954 chr2:178340520 T/G cg22681709 chr2:178499509 PDE11A -0.52 -9.52 -0.46 3.72e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs921968 0.510 rs620887 chr2:219465594 C/A cg02176678 chr2:219576539 TTLL4 0.75 14.43 0.62 5.06e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs9814567 0.896 rs4245907 chr3:134347876 C/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -5.77 -0.3 1.84e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 14.39 0.62 7.47e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11169552 0.510 rs10783376 chr12:50981249 C/G cg12884762 chr12:50931848 DIP2B -0.31 -5.65 -0.3 3.5e-8 Colorectal cancer; LUSC cis rs11587400 0.656 rs6689415 chr1:115107469 G/T cg12756093 chr1:115239321 AMPD1 0.4 5.89 0.31 9.27e-9 Autism; LUSC cis rs710216 0.957 rs12041787 chr1:43432275 G/C cg03128534 chr1:43423976 SLC2A1 0.47 5.86 0.31 1.09e-8 Red cell distribution width; LUSC cis rs11690935 0.851 rs6433319 chr2:172830953 C/T cg13550731 chr2:172543902 DYNC1I2 -0.73 -11.52 -0.53 4.47e-26 Schizophrenia; LUSC cis rs977987 0.778 rs7206541 chr16:75436713 A/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.79e-10 Dupuytren's disease; LUSC cis rs4629180 0.586 rs10206804 chr2:102132431 C/T cg04415270 chr2:102091202 RFX8 0.44 7.68 0.39 1.82e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg22307029 chr19:49891270 CCDC155 0.68 9.33 0.45 1.49e-18 Multiple sclerosis; LUSC cis rs10089 1.000 rs883074 chr5:127445823 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.81 -11.36 -0.53 1.66e-25 Ileal carcinoids; LUSC cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg25427524 chr10:38739819 LOC399744 0.44 7.48 0.38 6.6e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs73001065 0.901 rs73004959 chr19:19711139 C/T cg03709012 chr19:19516395 GATAD2A 0.91 7.2 0.37 4.06e-12 LDL cholesterol; LUSC cis rs6500395 1.000 rs9939103 chr16:48592376 G/C cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6582630 0.638 rs12231073 chr12:38526901 T/G cg13010199 chr12:38710504 ALG10B -0.44 -6.7 -0.34 8.94e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs9329221 0.710 rs11779205 chr8:10260100 C/T cg21775007 chr8:11205619 TDH 0.44 5.8 0.3 1.55e-8 Neuroticism; LUSC trans rs1493916 0.655 rs4534926 chr18:31349072 G/C cg13755796 chr4:20253514 NA -0.43 -6.66 -0.34 1.12e-10 Life satisfaction; LUSC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg11657440 chr19:46296263 DMWD 0.87 16.62 0.67 1.22e-45 Coronary artery disease; LUSC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg04369109 chr6:150039330 LATS1 0.59 8.76 0.43 9.94e-17 Lung cancer; LUSC cis rs9311676 0.656 rs4681679 chr3:58332068 A/G cg13750441 chr3:58318267 PXK -0.31 -5.88 -0.31 1.01e-8 Systemic lupus erythematosus; LUSC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg17211192 chr8:82754475 SNX16 0.74 9.96 0.48 1.22e-20 Diastolic blood pressure; LUSC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg20684491 chr1:25596433 NA -0.36 -5.69 -0.3 2.73e-8 Erythrocyte sedimentation rate; LUSC cis rs1395 1.000 rs2014252 chr2:27462405 T/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.37 5.98 0.31 5.78e-9 Blood metabolite levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02257048 chr17:78880031 RPTOR 0.47 6.68 0.34 9.77e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7561273 0.609 rs2080727 chr2:24350907 A/G cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs67072384 0.892 rs72964172 chr11:72436436 G/A cg04827223 chr11:72435913 ARAP1 -0.87 -7.72 -0.39 1.34e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg21918786 chr6:109611834 NA 0.39 6.66 0.34 1.12e-10 Reticulocyte fraction of red cells; LUSC cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg24692254 chr21:30365293 RNF160 -0.74 -11.36 -0.53 1.62e-25 Pancreatic cancer; LUSC cis rs3018712 0.590 rs4930236 chr11:68414000 C/A cg20283391 chr11:68216788 NA 0.57 5.72 0.3 2.42e-8 Total body bone mineral density; LUSC cis rs3812831 0.695 rs8000778 chr13:114944310 T/C cg08824895 chr13:115047677 UPF3A 0.56 8.69 0.43 1.63e-16 Schizophrenia; LUSC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg02487422 chr3:49467188 NICN1 0.46 7.2 0.37 4.02e-12 Resting heart rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23369371 chr2:220118598 TUBA4A;TUBA4B -0.41 -5.98 -0.31 5.61e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9388451 0.587 rs1739385 chr6:126099939 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.73 -12.68 -0.57 2.33e-30 Brugada syndrome; LUSC cis rs4664308 1.000 rs16844715 chr2:160915106 A/G cg03641300 chr2:160917029 PLA2R1 0.67 11.0 0.52 3.21e-24 Idiopathic membranous nephropathy; LUSC cis rs2625529 0.824 rs12592364 chr15:72284647 C/A cg16672083 chr15:72433130 SENP8 -0.51 -7.44 -0.38 8.7e-13 Red blood cell count; LUSC cis rs950169 0.579 rs881983 chr15:84647308 C/T cg12863693 chr15:85201151 NMB 0.34 6.31 0.33 8.89e-10 Schizophrenia; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg22903657 chr4:1355424 KIAA1530 -0.36 -6.08 -0.32 3.26e-9 Obesity-related traits; LUSC cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg23788917 chr6:8435910 SLC35B3 -0.48 -7.18 -0.37 4.68e-12 Motion sickness; LUSC cis rs889512 0.642 rs28439846 chr16:75280378 G/A cg04987608 chr16:75300043 BCAR1 -0.5 -5.74 -0.3 2.18e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17490626 0.568 rs12413529 chr10:71211644 G/T cg14388049 chr10:71211838 TSPAN15 -0.32 -5.81 -0.3 1.47e-8 Thrombosis; LUSC trans rs12439619 0.846 rs62012059 chr15:82544010 A/C cg04831495 chr15:85060580 GOLGA6L5 -0.47 -6.27 -0.32 1.13e-9 Intelligence (multi-trait analysis); LUSC cis rs2455601 0.608 rs11042104 chr11:8890924 C/G cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.08 0.36 8.82e-12 Schizophrenia; LUSC trans rs7746199 0.736 rs13212318 chr6:27688841 A/C cg01620082 chr3:125678407 NA -0.78 -7.29 -0.37 2.28e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs1908814 0.516 rs10113062 chr8:11793249 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.2e-15 Neuroticism; LUSC cis rs9747201 1.000 rs8082212 chr17:80175100 G/C cg18209359 chr17:80159595 CCDC57 -0.36 -5.83 -0.3 1.31e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7666738 0.515 rs11733968 chr4:98906448 A/C cg05340658 chr4:99064831 C4orf37 -0.59 -9.39 -0.46 9.69e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs356992 0.830 rs356991 chr2:60744872 T/G cg08426369 chr2:60753602 BCL11A 0.44 5.96 0.31 6.36e-9 Educational attainment (years of education); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02091366 chr17:16342131 NCRNA00188;SNORD49B;SNORD49A 0.4 6.23 0.32 1.44e-9 Triglycerides; LUSC cis rs3741404 0.609 rs687581 chr11:63871533 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.42 -6.82 -0.35 4.22e-11 Platelet count; LUSC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.4 0.33 5.28e-10 Hip circumference adjusted for BMI; LUSC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg24110177 chr3:50126178 RBM5 0.64 11.28 0.53 3.1e-25 Body mass index; LUSC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg00815214 chr21:47717953 NA -0.38 -6.16 -0.32 2.09e-9 Testicular germ cell tumor; LUSC cis rs7843479 0.601 rs12056476 chr8:21854188 T/A cg17168535 chr8:21777572 XPO7 0.81 14.64 0.63 7.42e-38 Mean corpuscular volume; LUSC cis rs9527 0.662 rs10786714 chr10:104598606 G/C cg15744005 chr10:104629667 AS3MT -0.3 -5.73 -0.3 2.29e-8 Arsenic metabolism; LUSC cis rs9462027 0.628 rs6899938 chr6:34749113 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC cis rs56399783 0.901 rs56356906 chr7:2774383 G/A cg14895029 chr7:2775587 GNA12 0.53 5.77 0.3 1.81e-8 Childhood ear infection; LUSC cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -11.76 -0.54 5.79e-27 Systemic lupus erythematosus; LUSC cis rs113835537 0.529 rs17496250 chr11:66270774 C/G cg24851651 chr11:66362959 CCS 0.53 7.73 0.39 1.31e-13 Airway imaging phenotypes; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.69 0.34 9.34e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg03929089 chr4:120376271 NA -0.83 -12.09 -0.55 3.76e-28 Coronary artery disease; LUSC cis rs17162190 0.698 rs4659443 chr1:26823631 C/T cg17456097 chr1:26900765 RPS6KA1 0.4 5.88 0.31 1.02e-8 Mean corpuscular volume; LUSC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.54 6.96 0.36 1.78e-11 Age-related macular degeneration (geographic atrophy); LUSC trans rs11098499 0.908 rs1002152 chr4:120273387 C/A cg25214090 chr10:38739885 LOC399744 0.53 7.78 0.39 9.04e-14 Corneal astigmatism; LUSC cis rs614226 0.935 rs2235222 chr12:120892193 G/C cg01236616 chr12:121019343 POP5 -1.34 -21.81 -0.77 3.35e-66 Type 1 diabetes nephropathy; LUSC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg25319279 chr11:5960081 NA -0.39 -5.87 -0.31 1.05e-8 DNA methylation (variation); LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg15242686 chr22:24348715 GSTTP1 0.41 6.13 0.32 2.42e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6570726 0.967 rs9497316 chr6:145792387 G/T cg23711669 chr6:146136114 FBXO30 -0.67 -11.61 -0.54 2.09e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 8.16e-15 Axial length; LUSC cis rs11190604 1.000 rs11816840 chr10:102309220 G/C cg16342193 chr10:102329863 NA -0.35 -6.27 -0.32 1.12e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg24675658 chr1:53192096 ZYG11B 0.72 11.91 0.55 1.75e-27 Monocyte count; LUSC cis rs9467773 0.620 rs2494694 chr6:26619328 A/T cg11502198 chr6:26597334 ABT1 0.7 11.83 0.54 3.39e-27 Intelligence (multi-trait analysis); LUSC trans rs62056376 0.646 rs1024610 chr17:32580231 A/T cg19986872 chr5:131347773 ACSL6 0.38 6.29 0.33 9.68e-10 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs9811920 0.555 rs68092024 chr3:99691522 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 6.96 0.36 1.8e-11 Axial length; LUSC cis rs983392 0.679 rs72920867 chr11:60005424 T/C cg20284999 chr11:59952153 MS4A6A -0.36 -6.01 -0.31 4.74e-9 Alzheimer's disease (late onset); LUSC cis rs6964587 0.934 rs1544377 chr7:91687351 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs11650494 0.808 rs61286260 chr17:47433222 T/C cg08112188 chr17:47440006 ZNF652 1.13 10.12 0.48 3.46e-21 Prostate cancer; LUSC trans rs2562456 0.558 rs62108173 chr19:21427188 C/T cg00806126 chr19:22604979 ZNF98 -0.42 -6.04 -0.31 4.05e-9 Pain; LUSC cis rs9395066 0.545 rs10948193 chr6:44949176 G/A cg25276700 chr6:44698697 NA 0.28 5.78 0.3 1.75e-8 Height; LUSC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg23093090 chr10:104574429 C10orf26 -0.39 -7.5 -0.38 5.84e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12421382 0.593 rs2118973 chr11:109389231 G/A cg27471124 chr11:109292789 C11orf87 0.38 6.94 0.35 2.08e-11 Schizophrenia; LUSC cis rs11587400 0.514 rs222499 chr1:115146488 C/A cg12756093 chr1:115239321 AMPD1 -0.43 -6.42 -0.33 4.67e-10 Autism; LUSC cis rs10504073 0.584 rs1511365 chr8:49975321 A/T cg00325661 chr8:49890786 NA 0.68 10.81 0.51 1.5e-23 Blood metabolite ratios; LUSC cis rs1559088 0.803 rs10411529 chr19:33616256 A/C cg17764715 chr19:33622953 WDR88 0.55 7.57 0.38 3.75e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg01171360 chr6:293285 DUSP22 -0.48 -7.01 -0.36 1.29e-11 Menopause (age at onset); LUSC cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg07606381 chr6:8435919 SLC35B3 0.75 12.72 0.57 1.74e-30 Motion sickness; LUSC cis rs7131987 0.903 rs1035604 chr12:29393102 G/A cg09582351 chr12:29534625 ERGIC2 -0.32 -6.54 -0.34 2.36e-10 QT interval; LUSC cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg04586622 chr2:25135609 ADCY3 0.4 8.37 0.42 1.58e-15 Body mass index; LUSC cis rs4631830 0.600 rs11004324 chr10:51496623 G/T cg16070123 chr10:51489643 NA -0.53 -7.89 -0.4 4.33e-14 Prostate-specific antigen levels; LUSC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg26566898 chr11:117069891 TAGLN 0.33 6.28 0.32 1.08e-9 Blood protein levels; LUSC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg24675056 chr1:15929824 NA 0.44 7.36 0.37 1.46e-12 Systolic blood pressure; LUSC cis rs13385 0.769 rs7727069 chr5:139573265 A/G cg26211634 chr5:139558579 C5orf32 0.44 6.31 0.33 8.82e-10 Atrial fibrillation; LUSC cis rs7113850 0.541 rs7102578 chr11:24244671 G/T ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6.23e-18 Bone fracture in osteoporosis; LUSC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg20818283 chr2:191399100 TMEM194B 0.45 6.98 0.36 1.59e-11 Pulse pressure; LUSC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.55 0.34 2.16e-10 Schizophrenia; LUSC cis rs2204008 0.744 rs11168870 chr12:37973333 A/G cg13010199 chr12:38710504 ALG10B 0.7 10.92 0.51 5.92e-24 Bladder cancer; LUSC cis rs4808199 0.947 rs10404728 chr19:19595014 C/T cg03709012 chr19:19516395 GATAD2A 1.09 14.67 0.63 6.13e-38 Nonalcoholic fatty liver disease; LUSC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg12615879 chr12:58013172 SLC26A10 0.28 5.76 0.3 1.92e-8 Multiple sclerosis; LUSC cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.37 0.33 6.28e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs908922 0.676 rs1538083 chr1:152517116 A/G cg20991723 chr1:152506922 NA 0.5 9.52 0.46 3.74e-19 Hair morphology; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg22907277 chr7:1156413 C7orf50 0.49 7.43 0.38 9.12e-13 Longevity;Endometriosis; LUSC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg08470875 chr2:26401718 FAM59B -0.66 -8.86 -0.44 4.75e-17 Gut microbiome composition (summer); LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg06675538 chr2:114033490 PAX8;LOC440839 -0.32 -5.7 -0.3 2.68e-8 Lymphocyte counts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04829863 chr8:116680636 TRPS1 0.47 6.17 0.32 1.92e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg20203395 chr5:56204925 C5orf35 -0.46 -6.74 -0.35 6.98e-11 Coronary artery disease; LUSC cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg19628046 chr18:33552617 C18orf21 0.51 6.17 0.32 1.96e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg00343986 chr7:65444356 GUSB -0.38 -5.71 -0.3 2.46e-8 Aortic root size; LUSC cis rs1983891 1.000 rs9381082 chr6:41542214 T/C cg15051332 chr6:41514432 FOXP4 0.41 5.91 0.31 8.43e-9 Prostate cancer; LUSC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -12.11 -0.55 3.2e-28 Extrinsic epigenetic age acceleration; LUSC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg13114125 chr14:105738426 BRF1 -0.9 -15.6 -0.65 1.38e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg22800045 chr5:56110881 MAP3K1 0.75 9.61 0.47 1.89e-19 Initial pursuit acceleration; LUSC cis rs6012953 0.730 rs6020562 chr20:49119606 G/C cg13958625 chr20:49123093 NA 0.28 6.01 0.31 4.81e-9 Vitiligo; LUSC cis rs7917772 0.582 rs10748826 chr10:104354804 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.94 0.51 5.25e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg25427524 chr10:38739819 LOC399744 -0.61 -11.02 -0.52 2.61e-24 Extrinsic epigenetic age acceleration; LUSC cis rs11098499 0.588 rs6534149 chr4:120559292 T/G cg24375607 chr4:120327624 NA -0.62 -9.83 -0.47 3.3e-20 Corneal astigmatism; LUSC trans rs11992162 0.591 rs34123222 chr8:11795349 C/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.32 -0.33 8.32e-10 Monocyte count; LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg04944784 chr2:26401820 FAM59B 0.78 11.14 0.52 1.04e-24 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02522952 chr6:119671260 MAN1A1 -0.47 -6.1 -0.32 2.94e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.7 11.51 0.53 4.92e-26 Prudent dietary pattern; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27194164 chr19:17666205 GLT25D1 -0.49 -6.21 -0.32 1.56e-9 Bipolar disorder and schizophrenia; LUSC trans rs4729127 1.000 rs17166212 chr7:94008385 A/G cg14660007 chr13:78271894 SLAIN1 0.5 6.45 0.33 3.88e-10 Intelligence; LUSC cis rs6460942 0.908 rs77034890 chr7:12244506 A/T cg06484146 chr7:12443880 VWDE -0.59 -5.88 -0.31 9.76e-9 Coronary artery disease; LUSC cis rs796364 0.755 rs203762 chr2:200905136 C/A cg23649088 chr2:200775458 C2orf69 -0.57 -7.01 -0.36 1.33e-11 Schizophrenia; LUSC cis rs72717009 0.825 rs7529425 chr1:161479599 G/A cg23840854 chr1:161414152 NA -0.91 -11.11 -0.52 1.34e-24 Rheumatoid arthritis; LUSC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg03351412 chr1:154909251 PMVK 0.56 8.87 0.44 4.52e-17 Prostate cancer; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg27094323 chr7:1216898 NA -0.43 -7.22 -0.37 3.62e-12 Longevity;Endometriosis; LUSC cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg21665744 chr7:39171113 POU6F2 0.44 6.54 0.34 2.24e-10 IgG glycosylation; LUSC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg02807482 chr3:125708958 NA -0.5 -6.12 -0.32 2.67e-9 Blood pressure (smoking interaction); LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.42 0.38 9.97e-13 Bipolar disorder; LUSC cis rs10781543 0.776 rs11145760 chr9:139382594 G/A cg14169450 chr9:139327907 INPP5E 0.46 8.22 0.41 4.61e-15 Monocyte percentage of white cells; LUSC cis rs6537837 0.887 rs17024195 chr1:110143755 G/T cg05049280 chr1:110155535 GNAT2 0.45 6.73 0.35 7.22e-11 Major depressive disorder; LUSC trans rs9929218 1.000 rs2113201 chr16:68815000 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.53 -0.53 3.92e-26 Colorectal cancer; LUSC cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs1322512 1.000 rs2758782 chr6:153010341 C/T cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg00106254 chr7:1943704 MAD1L1 -0.41 -5.98 -0.31 5.6e-9 Bipolar disorder and schizophrenia; LUSC cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg11189052 chr15:85197271 WDR73 -0.42 -5.99 -0.31 5.43e-9 P wave terminal force; LUSC cis rs1832871 0.521 rs878585 chr6:158815897 C/T cg07165851 chr6:158734300 TULP4 0.4 6.39 0.33 5.42e-10 Height; LUSC cis rs713477 1.000 rs12893964 chr14:55912268 T/C cg04306507 chr14:55594613 LGALS3 -0.29 -5.68 -0.3 2.99e-8 Pediatric bone mineral content (femoral neck); LUSC cis rs2073300 0.609 rs6137948 chr20:23416845 G/A cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.47 0.38 6.86e-13 Menarche (age at onset); LUSC cis rs983392 0.709 rs1426250 chr11:60001325 A/G cg24026212 chr11:59952134 MS4A6A -0.35 -6.11 -0.32 2.73e-9 Alzheimer's disease (late onset); LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg05368731 chr17:41323189 NBR1 0.93 15.66 0.65 7.69e-42 Menopause (age at onset); LUSC cis rs28829049 0.570 rs12060125 chr1:19391108 A/G cg13387374 chr1:19411106 UBR4 -0.43 -6.26 -0.32 1.16e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg01411255 chr17:61851458 DDX42;CCDC47 -1.01 -21.47 -0.76 7.5e-65 Height; LUSC cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg12935359 chr14:103987150 CKB -0.61 -9.89 -0.48 2.12e-20 Intelligence (multi-trait analysis); LUSC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.46 7.89 0.4 4.26e-14 Breast cancer; LUSC cis rs1801251 1.000 rs7558609 chr2:233700379 C/T cg25237894 chr2:233734115 C2orf82 0.37 6.95 0.36 1.93e-11 Coronary artery disease; LUSC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg04369109 chr6:150039330 LATS1 -0.59 -8.76 -0.43 1.02e-16 Lung cancer; LUSC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.17e-10 Aortic root size; LUSC cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs7572644 0.640 rs11127125 chr2:28023120 T/C cg27432699 chr2:27873401 GPN1 0.56 7.36 0.37 1.46e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg08499158 chr17:42289980 UBTF -0.49 -8.28 -0.41 3.05e-15 Total body bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18159740 chr13:30881703 KATNAL1 0.43 6.29 0.33 1.02e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1801251 0.929 rs10933409 chr2:233629386 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.59 0.34 1.69e-10 Coronary artery disease; LUSC cis rs5758659 0.652 rs133326 chr22:42406885 G/A cg15557168 chr22:42548783 NA -0.33 -5.67 -0.3 3.11e-8 Cognitive function; LUSC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg02269571 chr22:50332266 NA -0.58 -8.67 -0.43 1.97e-16 Schizophrenia; LUSC cis rs13385 0.769 rs2053058 chr5:139563483 T/C cg26211634 chr5:139558579 C5orf32 0.45 6.54 0.34 2.25e-10 Atrial fibrillation; LUSC cis rs7267979 1.000 rs10966 chr20:25282944 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.14 0.74 1.3e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7267979 1.000 rs6050566 chr20:25351071 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.1 -0.74 1.91e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg04315214 chr1:2043799 PRKCZ -0.37 -7.1 -0.36 7.39e-12 Height; LUSC cis rs2290416 0.892 rs3793372 chr8:144664233 A/C cg26536354 chr8:144654954 C8orf73 0.61 6.85 0.35 3.61e-11 Attention deficit hyperactivity disorder; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg01238044 chr22:24384105 GSTT1 0.52 7.59 0.38 3.23e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs603424 0.551 rs610745 chr10:102089436 G/A cg10365880 chr10:102089681 PKD2L1 0.59 6.76 0.35 6.1e-11 Phospholipid levels (plasma);Palmitic acid (16:0) levels;Palmitoleic acid (16:1n-7) levels;Mean platelet volume;Serum metabolite levels;Blood metabolite levels;Vaccenic acid (18:1n-7) levels;Metabolic traits;Coronary artery disease;Blood metabolite ratios;Glycerophospholipid levels; LUSC cis rs3755132 0.929 rs976015 chr2:15772546 C/G cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg21782813 chr7:2030301 MAD1L1 0.44 7.25 0.37 3.01e-12 Bipolar disorder and schizophrenia; LUSC cis rs6867032 0.527 rs13190594 chr5:2012474 T/C cg26168224 chr5:2018326 NA 0.6 10.28 0.49 1.04e-21 Gut microbiome composition (winter); LUSC trans rs1908814 0.516 rs10113062 chr8:11793249 A/G cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.77e-9 Neuroticism; LUSC cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg05283184 chr6:79620031 NA -0.58 -12.41 -0.56 2.39e-29 Intelligence (multi-trait analysis); LUSC cis rs78456975 0.943 rs7602369 chr2:1574754 T/C cg01028140 chr2:1542097 TPO -0.49 -6.94 -0.36 2e-11 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7296418 0.663 rs11057276 chr12:123820397 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.33 6.32 0.33 8.58e-10 Platelet count; LUSC cis rs12908161 1.000 rs62021219 chr15:85256159 C/T cg17507749 chr15:85114479 UBE2QP1 0.56 6.91 0.35 2.45e-11 Schizophrenia; LUSC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg15556689 chr8:8085844 FLJ10661 0.56 9.02 0.44 1.46e-17 Joint mobility (Beighton score); LUSC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg19052272 chr2:3704530 ALLC -0.46 -7.58 -0.38 3.35e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg24838063 chr12:130822603 PIWIL1 0.71 11.02 0.52 2.72e-24 Menopause (age at onset); LUSC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg16447950 chr5:562315 NA -0.54 -6.59 -0.34 1.77e-10 Obesity-related traits; LUSC cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg05043794 chr9:111880884 C9orf5 -0.34 -7.15 -0.36 5.42e-12 Menarche (age at onset); LUSC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg01475377 chr6:109611718 NA -0.46 -8.37 -0.42 1.59e-15 Reticulocyte fraction of red cells; LUSC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg04362960 chr10:104952993 NT5C2 0.47 5.88 0.31 9.95e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs35767 0.841 rs860598 chr12:102898446 C/T cg12923613 chr4:83812206 SEC31A 0.49 5.98 0.31 5.86e-9 Homeostasis model assessment of insulin resistance;Fasting blood insulin; LUSC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 6.95 0.36 1.95e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6456156 0.586 rs1358882 chr6:167467101 G/A cg06454157 chr6:167490870 NA -0.28 -6.77 -0.35 5.86e-11 Primary biliary cholangitis; LUSC cis rs1729951 0.575 rs1654904 chr3:136681149 T/C cg12473912 chr3:136751656 NA 0.39 6.74 0.35 6.96e-11 Neuroticism; LUSC cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg17063962 chr7:91808500 NA 0.6 9.39 0.46 9.48e-19 Breast cancer; LUSC cis rs765787 0.530 rs11639403 chr15:45538350 A/G cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00316777 chr8:86376489 CA2 -0.41 -6.29 -0.33 1.02e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7119 0.636 rs11635606 chr15:77819591 A/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.39 -0.33 5.48e-10 Type 2 diabetes; LUSC cis rs9399401 0.710 rs10484733 chr6:142710988 C/G cg04461802 chr6:142623433 GPR126 0.47 5.87 0.31 1.06e-8 Chronic obstructive pulmonary disease; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg00945038 chr17:61921165 SMARCD2 0.51 8.47 0.42 7.97e-16 Prudent dietary pattern; LUSC cis rs1160297 0.585 rs12713227 chr2:53090018 A/G cg07782112 chr2:53107842 NA 0.37 6.24 0.32 1.3e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs7508679 1.000 rs10410204 chr19:7224350 C/T cg00428638 chr19:7224713 INSR 0.37 7.8 0.39 8.1e-14 Hypothyroidism; LUSC trans rs10771431 0.935 rs1117735 chr12:9372728 G/A cg27600084 chr12:12264075 NA 0.45 6.64 0.34 1.26e-10 Breast size; LUSC cis rs6964587 1.000 rs56072181 chr7:91690457 A/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs9314323 0.767 rs10866848 chr8:26208209 G/C cg13160058 chr8:26243215 BNIP3L -0.41 -7.12 -0.36 6.83e-12 Red cell distribution width; LUSC cis rs1728785 1.000 rs1645938 chr16:68595197 G/A cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.45e-10 Ulcerative colitis; LUSC cis rs4689388 0.890 rs4481292 chr4:6298375 C/T cg14416269 chr4:6271139 WFS1 0.52 10.7 0.51 3.6e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs941408 0.515 rs1640262 chr19:2779134 C/T cg22153745 chr1:153894579 GATAD2B 0.5 6.92 0.35 2.27e-11 Total cholesterol levels; LUSC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs12286929 0.646 rs12805914 chr11:115019739 T/A cg04055981 chr11:115044050 NA 0.35 5.96 0.31 6.34e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.14 0.41 7.67e-15 Homoarginine levels; LUSC cis rs4803468 1.000 rs10853751 chr19:41903220 G/A cg09537434 chr19:41945824 ATP5SL -0.89 -15.75 -0.65 3.35e-42 Height; LUSC cis rs9472414 0.510 rs609699 chr6:44705266 G/A cg20913747 chr6:44695427 NA 0.38 5.77 0.3 1.81e-8 Height; LUSC trans rs11098499 1.000 rs58601355 chr4:120186367 T/C cg25214090 chr10:38739885 LOC399744 0.49 7.2 0.37 3.9e-12 Corneal astigmatism; LUSC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11890956 chr21:40555474 PSMG1 1.03 21.0 0.75 5.38e-63 Cognitive function; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg20060089 chr17:41561319 DHX8 0.36 6.17 0.32 2.02e-9 Tuberculosis; LUSC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg04155289 chr7:94953770 PON1 -0.34 -5.72 -0.3 2.42e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs61931739 0.534 rs11052983 chr12:34045787 C/A cg26384229 chr12:38710491 ALG10B 0.7 10.84 0.51 1.21e-23 Morning vs. evening chronotype; LUSC cis rs11048434 0.736 rs1476911 chr12:9090859 C/T cg13575925 chr12:9217583 LOC144571 0.33 5.99 0.31 5.42e-9 Sjögren's syndrome; LUSC cis rs17125944 0.615 rs7151474 chr14:53313680 C/T cg00686598 chr14:53173677 PSMC6 -0.62 -5.82 -0.3 1.36e-8 Alzheimer's disease (late onset); LUSC cis rs7712401 0.601 rs193539 chr5:122257617 C/G cg19077854 chr5:122220652 SNX24 0.41 9.19 0.45 4.27e-18 Mean platelet volume; LUSC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 8.11 0.41 9.9e-15 Bipolar disorder; LUSC cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg18681998 chr4:17616180 MED28 -0.71 -11.81 -0.54 3.83e-27 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11931598 0.702 rs10937780 chr4:7048842 A/G cg26116260 chr4:7069785 GRPEL1 -0.44 -6.75 -0.35 6.59e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs1577917 0.958 rs2084294 chr6:86565943 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.66 -0.34 1.1e-10 Response to antipsychotic treatment; LUSC cis rs2985684 1.000 rs3007030 chr14:50086563 C/T cg04989706 chr14:50066350 PPIL5 -0.45 -5.77 -0.3 1.85e-8 Carotid intima media thickness; LUSC cis rs7707921 0.801 rs862243 chr5:81586829 C/G cg15871215 chr5:81402204 ATG10 0.45 7.07 0.36 8.95e-12 Breast cancer; LUSC cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg06627628 chr2:24431161 ITSN2 -0.6 -7.34 -0.37 1.66e-12 Lymphocyte counts; LUSC cis rs909341 0.818 rs2259858 chr20:62346459 A/T cg09650180 chr20:62225654 GMEB2 -0.45 -5.84 -0.3 1.27e-8 Atopic dermatitis; LUSC cis rs2274273 0.682 rs1201378 chr14:55493408 A/G cg04306507 chr14:55594613 LGALS3 -0.5 -10.93 -0.51 5.72e-24 Protein biomarker; LUSC cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg23711669 chr6:146136114 FBXO30 0.77 13.91 0.61 5.36e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg12463550 chr7:65579703 CRCP -0.42 -6.05 -0.31 3.89e-9 Aortic root size; LUSC cis rs9646944 0.540 rs12712148 chr2:103025547 G/A cg20060108 chr2:102954350 IL1RL1 0.48 6.6 0.34 1.65e-10 Blood protein levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04802657 chr16:28565199 CCDC101 0.74 6.2 0.32 1.67e-9 Cognitive performance; LUSC cis rs1371867 0.875 rs1788168 chr8:101324960 G/T cg00191853 chr8:101177733 SPAG1 -0.38 -6.34 -0.33 7.3e-10 Atrioventricular conduction; LUSC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg27398817 chr8:82754497 SNX16 0.64 8.13 0.41 8.71e-15 Diastolic blood pressure; LUSC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06544989 chr22:39130855 UNC84B 0.33 5.74 0.3 2.12e-8 Menopause (age at onset); LUSC cis rs72781680 0.898 rs17509001 chr2:24021231 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs8060686 0.516 rs7184821 chr16:68270229 T/C cg05110241 chr16:68378359 PRMT7 -0.49 -6.1 -0.32 2.92e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6815814 0.950 rs67206233 chr4:38807853 T/C cg02016764 chr4:38805732 TLR1 -0.54 -5.92 -0.31 7.93e-9 Breast cancer; LUSC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg03709012 chr19:19516395 GATAD2A 0.85 14.43 0.62 4.84e-37 Tonsillectomy; LUSC cis rs7512552 0.839 rs834232 chr1:150354682 T/C cg15654264 chr1:150340011 RPRD2 0.62 10.29 0.49 9.57e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9311676 0.656 rs62258081 chr3:58367705 A/C cg13750441 chr3:58318267 PXK 0.35 6.84 0.35 3.72e-11 Systemic lupus erythematosus; LUSC cis rs3020736 0.500 rs7364293 chr22:42506370 C/T cg05082376 chr22:42548792 NA 0.43 6.59 0.34 1.73e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.05 -0.36 1.01e-11 Blood metabolite levels; LUSC cis rs17030434 0.654 rs10021447 chr4:154646459 A/C cg14289246 chr4:154710475 SFRP2 -0.46 -6.05 -0.31 3.98e-9 Electrocardiographic conduction measures; LUSC cis rs9549367 0.713 rs3024769 chr13:113825601 A/C cg18105134 chr13:113819100 PROZ 0.67 9.83 0.47 3.31e-20 Platelet distribution width; LUSC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg15445000 chr17:37608096 MED1 -0.41 -6.98 -0.36 1.59e-11 Glomerular filtration rate (creatinine); LUSC cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg13010199 chr12:38710504 ALG10B -0.58 -9.15 -0.45 5.64e-18 Bladder cancer; LUSC cis rs1413885 0.525 rs1334878 chr1:65846124 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.99 0.36 1.49e-11 Anticoagulant levels; LUSC trans rs61931739 0.890 rs1705750 chr12:34142648 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.7 0.34 8.99e-11 Morning vs. evening chronotype; LUSC cis rs868036 0.522 rs3784711 chr15:68072527 C/T cg08079166 chr15:68083412 MAP2K5 -0.38 -8.24 -0.41 3.96e-15 Restless legs syndrome; LUSC cis rs7119 0.717 rs12902896 chr15:77809150 G/T cg27398640 chr15:77910606 LINGO1 0.3 6.47 0.33 3.51e-10 Type 2 diabetes; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg17946375 chr10:126150274 LHPP -0.43 -6.57 -0.34 1.88e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.51 0.34 2.8e-10 Schizophrenia; LUSC cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.88e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg27170947 chr2:26402098 FAM59B -0.67 -10.14 -0.49 2.95e-21 Gut microbiome composition (summer); LUSC cis rs6578985 1.000 rs868330 chr11:2136605 A/G cg25742037 chr11:2171694 INS-IGF2;IGF2 0.32 5.91 0.31 8.31e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs308403 0.600 rs309361 chr4:123657978 A/T cg10495464 chr4:123653540 BBS12;LOC729338 0.83 11.53 0.53 3.9e-26 Blood protein levels; LUSC cis rs6574644 1.000 rs4903979 chr14:81778158 T/C cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs67460515 0.563 rs4494975 chr3:160866768 C/T cg03342759 chr3:160939853 NMD3 -0.48 -6.55 -0.34 2.24e-10 Parkinson's disease; LUSC cis rs4423214 0.879 rs1790353 chr11:71136730 C/T cg05163923 chr11:71159392 DHCR7 -0.66 -8.52 -0.42 5.58e-16 Vitamin D levels; LUSC cis rs742132 0.527 rs17252870 chr6:25494666 A/C cg03264133 chr6:25882463 NA -0.45 -6.26 -0.32 1.2e-9 Uric acid levels; LUSC cis rs7267979 1.000 rs6115153 chr20:25325567 T/C cg08601574 chr20:25228251 PYGB -0.42 -6.35 -0.33 7.19e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1595825 0.838 rs73058854 chr2:198885060 G/A cg00982548 chr2:198649783 BOLL -0.56 -7.06 -0.36 9.65e-12 Ulcerative colitis; LUSC cis rs3106136 0.967 rs12643901 chr4:95145132 C/T cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.12 -0.32 2.68e-9 Capecitabine sensitivity; LUSC cis rs739401 0.572 rs404629 chr11:3077025 A/G cg05729581 chr11:3078854 CARS -0.58 -8.91 -0.44 3.36e-17 Longevity; LUSC cis rs2629751 0.512 rs2722169 chr12:104415450 C/T cg14987745 chr12:104360022 TDG -0.7 -8.67 -0.43 1.92e-16 Hepatitis C induced liver fibrosis; LUSC cis rs1044826 0.642 rs6799312 chr3:139211932 C/T cg15131784 chr3:139108705 COPB2 0.4 6.38 0.33 6.03e-10 Obesity-related traits; LUSC cis rs6700896 0.522 rs59258332 chr1:66143591 C/G cg14976592 chr1:65886160 LEPROT;LEPR 0.51 6.03 0.31 4.25e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.56e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs427394 0.802 rs274694 chr5:6734079 A/G cg10857441 chr5:6722123 POLS -0.47 -9.02 -0.44 1.56e-17 Menopause (age at onset); LUSC cis rs13088645 0.532 rs9857134 chr3:134161607 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.46 6.02 0.31 4.72e-9 Coronary artery disease; LUSC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg00343127 chr12:129299088 SLC15A4;MGC16384 0.35 5.67 0.3 3.11e-8 Systemic lupus erythematosus; LUSC cis rs6700896 0.931 rs1892534 chr1:66105944 C/T cg04111102 chr1:66153794 NA 0.31 6.82 0.35 4.16e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg19875535 chr5:140030758 IK -0.54 -8.88 -0.44 4.18e-17 Depressive symptoms (multi-trait analysis); LUSC trans rs7937682 0.889 rs567859 chr11:111486738 A/G cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg15744005 chr10:104629667 AS3MT -0.29 -6.24 -0.32 1.36e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2486288 0.656 rs11632778 chr15:45551056 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.02e-14 Glomerular filtration rate; LUSC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg22535103 chr8:58192502 C8orf71 -0.58 -7.01 -0.36 1.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg23283495 chr1:209979779 IRF6 0.44 7.21 0.37 3.74e-12 Monobrow; LUSC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg24060327 chr5:131705240 SLC22A5 -0.52 -8.78 -0.43 8.45e-17 Breast cancer; LUSC cis rs10911232 0.507 rs10911199 chr1:182998036 T/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs113835537 0.529 rs2305532 chr11:66298594 C/T cg24851651 chr11:66362959 CCS 0.54 7.86 0.4 5.2e-14 Airway imaging phenotypes; LUSC cis rs4888262 0.545 rs7193959 chr16:74664969 T/A cg01733217 chr16:74700730 RFWD3 0.78 12.74 0.57 1.44e-30 Testicular germ cell tumor; LUSC cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.72e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -7.42 -0.38 9.48e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.2 0.32 1.69e-9 Multiple sclerosis; LUSC cis rs55665837 1.000 rs7945167 chr11:14451820 T/G cg05501817 chr11:14380813 RRAS2 -0.41 -6.53 -0.34 2.5e-10 Vitamin D levels; LUSC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg15448220 chr1:150897856 SETDB1 0.42 6.25 0.32 1.24e-9 Melanoma; LUSC cis rs870825 0.616 rs12502860 chr4:185636105 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC cis rs6693567 0.826 rs1260387 chr1:150371448 T/C cg15654264 chr1:150340011 RPRD2 0.43 6.03 0.31 4.45e-9 Migraine; LUSC cis rs35883536 0.626 rs80052576 chr1:101039229 A/G cg09408571 chr1:101003634 GPR88 -0.29 -5.73 -0.3 2.24e-8 Monocyte count; LUSC cis rs225245 0.765 rs226428 chr17:34049950 C/T cg05299278 chr17:33885742 SLFN14 -0.29 -6.41 -0.33 4.96e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs6964587 1.000 rs13231820 chr7:91663529 A/G cg17063962 chr7:91808500 NA 0.56 8.67 0.43 1.93e-16 Breast cancer; LUSC trans rs979233 0.502 rs276246 chr5:42062189 T/C cg07010552 chr17:7358735 CHRNB1 -0.41 -6.02 -0.31 4.72e-9 Systemic lupus erythematosus; LUSC trans rs61931739 0.500 rs11053260 chr12:34530215 T/G cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11644478 chr21:40555479 PSMG1 -0.67 -10.59 -0.5 8.39e-23 Menarche (age at onset); LUSC trans rs8002861 0.935 rs9567299 chr13:44456969 G/A cg12856521 chr11:46389249 DGKZ 0.4 6.27 0.32 1.09e-9 Leprosy; LUSC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg14004847 chr7:1930337 MAD1L1 -0.53 -7.85 -0.39 5.65e-14 Bipolar disorder and schizophrenia; LUSC cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Bone mineral density; LUSC cis rs9790314 0.521 rs1450523 chr3:161077270 G/A cg04691961 chr3:161091175 C3orf57 -0.36 -5.65 -0.3 3.51e-8 Morning vs. evening chronotype; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg05222119 chr17:80211999 CSNK1D -0.45 -6.67 -0.34 1.04e-10 N-glycan levels; LUSC cis rs1348850 0.598 rs12616259 chr2:178503803 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.09 0.32 3.11e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs5758511 0.680 rs739147 chr22:42671066 T/G cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.87 -0.31 1.07e-8 Birth weight; LUSC cis rs4919087 1.000 rs11189127 chr10:99079023 G/A cg25902810 chr10:99078978 FRAT1 0.5 7.47 0.38 6.94e-13 Monocyte count; LUSC trans rs10435719 0.647 rs10092605 chr8:11787395 T/G cg27411982 chr8:10470053 RP1L1 0.39 6.06 0.31 3.57e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs11098499 0.954 rs10008459 chr4:120394231 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.28 0.32 1.08e-9 Corneal astigmatism; LUSC cis rs7098414 0.511 rs10749592 chr10:82150891 C/T cg01528321 chr10:82214614 TSPAN14 0.59 8.84 0.44 5.79e-17 Post bronchodilator FEV1; LUSC cis rs2294693 0.680 rs4714423 chr6:41012483 C/A cg14769373 chr6:40998127 UNC5CL -0.44 -6.21 -0.32 1.59e-9 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg23711669 chr6:146136114 FBXO30 0.91 17.89 0.7 1.12e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs7577696 0.512 rs9789593 chr2:32381110 T/G cg02381751 chr2:32503542 YIPF4 -0.53 -6.93 -0.35 2.2e-11 Inflammatory biomarkers; LUSC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg11845111 chr2:191398756 TMEM194B 0.55 9.44 0.46 6.49e-19 Pulse pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06557630 chr16:49889701 NA -0.44 -5.97 -0.31 6.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs1775715 1.000 rs1251363 chr10:32328526 G/C cg18675610 chr10:32216311 ARHGAP12 -0.3 -6.17 -0.32 2.03e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6964587 0.967 rs55801687 chr7:91762629 C/A cg22117172 chr7:91764530 CYP51A1 0.33 5.84 0.3 1.23e-8 Breast cancer; LUSC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg22549504 chr19:17448937 GTPBP3 0.53 6.64 0.34 1.29e-10 Systemic lupus erythematosus; LUSC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.59 -0.54 2.42e-26 Schizophrenia; LUSC trans rs6981523 0.553 rs2409730 chr8:11060638 C/A cg15556689 chr8:8085844 FLJ10661 -0.54 -7.46 -0.38 7.64e-13 Neuroticism; LUSC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg22535103 chr8:58192502 C8orf71 -0.58 -7.03 -0.36 1.2e-11 Developmental language disorder (linguistic errors); LUSC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg13683864 chr3:40499215 RPL14 -0.94 -16.01 -0.66 3.38e-43 Renal cell carcinoma; LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg26513180 chr16:89883248 FANCA -0.88 -16.52 -0.67 3.12e-45 Vitiligo; LUSC trans rs9929218 0.954 rs9929479 chr16:68821271 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.34 -0.53 1.92e-25 Colorectal cancer; LUSC trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC trans rs2727020 0.658 rs10839269 chr11:49385596 A/G cg15704280 chr7:45808275 SEPT13 -1.09 -20.76 -0.75 4.76e-62 Coronary artery disease; LUSC cis rs9393777 0.623 rs2093169 chr6:26495099 C/T cg12292205 chr6:26970375 C6orf41 -0.62 -7.38 -0.37 1.3e-12 Intelligence (multi-trait analysis); LUSC cis rs11864453 0.612 rs11862813 chr16:72132356 C/T cg01557791 chr16:72042693 DHODH -0.43 -6.53 -0.34 2.42e-10 Fibrinogen levels; LUSC cis rs77216612 1.000 rs77216612 chr12:12877983 A/G cg04607235 chr12:12878440 APOLD1 -0.95 -15.59 -0.65 1.52e-41 Lymphocyte counts; LUSC cis rs6977660 0.619 rs10223937 chr7:19787697 C/T cg07541023 chr7:19748670 TWISTNB 0.62 6.84 0.35 3.71e-11 Thyroid stimulating hormone; LUSC cis rs9329221 0.651 rs2975648 chr8:10135976 C/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.79 -0.3 1.6e-8 Neuroticism; LUSC cis rs644148 0.836 rs2686777 chr19:45000386 T/C cg15540054 chr19:45004280 ZNF180 -0.62 -9.16 -0.45 5.44e-18 Personality dimensions; LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -10.26 -0.49 1.18e-21 Platelet count; LUSC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg14895029 chr7:2775587 GNA12 -0.43 -6.8 -0.35 4.74e-11 Height; LUSC trans rs2243480 0.803 rs34804747 chr7:65412942 G/C cg10756647 chr7:56101905 PSPH 0.86 8.4 0.42 1.27e-15 Diabetic kidney disease; LUSC trans rs11098499 0.954 rs6846442 chr4:120326323 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs11864453 0.647 rs3764314 chr16:72127078 T/C cg01557791 chr16:72042693 DHODH -0.46 -6.84 -0.35 3.81e-11 Fibrinogen levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01861349 chr15:75198956 C15orf17 -0.51 -6.47 -0.33 3.45e-10 Bipolar disorder and schizophrenia; LUSC cis rs12410462 0.581 rs7543931 chr1:227550976 A/T cg04117972 chr1:227635322 NA 0.63 6.9 0.35 2.59e-11 Major depressive disorder; LUSC cis rs12681288 0.823 rs2701908 chr8:1003250 T/C cg04851639 chr8:1020857 NA -0.39 -8.25 -0.41 3.8e-15 Schizophrenia; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg18538332 chr22:24372958 LOC391322 0.31 5.67 0.3 3.09e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7746199 0.668 rs34864796 chr6:27459923 G/A cg01620082 chr3:125678407 NA -0.68 -6.72 -0.35 7.9e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9326248 0.581 rs10892061 chr11:116886114 C/T cg11861562 chr11:117069780 TAGLN 0.32 6.21 0.32 1.61e-9 Blood protein levels; LUSC cis rs11105298 0.891 rs12228177 chr12:89862030 G/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.22 -0.37 3.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg05132306 chr1:1846340 CALML6 0.31 7.89 0.4 4.33e-14 Body mass index; LUSC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg09035930 chr12:129282057 SLC15A4 0.66 13.28 0.59 1.37e-32 Systemic lupus erythematosus; LUSC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg18477163 chr1:228402036 OBSCN -0.56 -10.2 -0.49 1.97e-21 Diastolic blood pressure; LUSC cis rs4423214 0.570 rs7118246 chr11:71231124 G/C cg05163923 chr11:71159392 DHCR7 0.6 7.73 0.39 1.31e-13 Vitamin D levels; LUSC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg03676636 chr4:99064102 C4orf37 0.32 7.05 0.36 1.06e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs7043114 0.563 rs10820986 chr9:95312961 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.35 -6.2 -0.32 1.65e-9 Height; LUSC cis rs13315871 1.000 rs13066269 chr3:58449244 T/C cg12435725 chr3:58293450 RPP14 -0.7 -6.93 -0.35 2.21e-11 Cholesterol, total; LUSC cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs1348850 0.526 rs7607073 chr2:178375065 C/A cg22681709 chr2:178499509 PDE11A -0.45 -6.65 -0.34 1.19e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4242434 0.927 rs10095121 chr8:22538426 A/G cg03733263 chr8:22462867 KIAA1967 0.86 14.08 0.61 1.14e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs4319547 0.737 rs11058226 chr12:122938958 A/G cg05707623 chr12:122985044 ZCCHC8 -0.59 -6.93 -0.35 2.23e-11 Body mass index; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg10774155 chr7:65338427 VKORC1L1 -0.39 -5.65 -0.3 3.52e-8 Calcium levels; LUSC cis rs3845702 0.877 rs12693216 chr2:180839793 T/A cg01881094 chr2:180872142 CWC22 -0.82 -10.71 -0.51 3.19e-23 Schizophrenia; LUSC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg18350739 chr11:68623251 NA -0.37 -6.48 -0.33 3.28e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7520050 0.778 rs2991985 chr1:46080530 T/C cg15605315 chr1:45957053 TESK2 0.38 5.74 0.3 2.13e-8 Red blood cell count;Reticulocyte count; LUSC cis rs9911578 0.967 rs7214892 chr17:57065401 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.46 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg20203395 chr5:56204925 C5orf35 -0.74 -10.2 -0.49 1.89e-21 Initial pursuit acceleration; LUSC cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg26384229 chr12:38710491 ALG10B 0.86 14.28 0.62 2e-36 Bladder cancer; LUSC trans rs9329221 0.537 rs12678797 chr8:9978919 A/G cg21775007 chr8:11205619 TDH -0.44 -6.41 -0.33 4.95e-10 Neuroticism; LUSC cis rs12681288 0.862 rs7814231 chr8:1021103 A/G cg04851639 chr8:1020857 NA -0.39 -8.12 -0.41 9.16e-15 Schizophrenia; LUSC trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs977987 0.843 rs11860231 chr16:75385159 A/G cg04384234 chr16:75411784 CFDP1 -0.39 -6.19 -0.32 1.79e-9 Dupuytren's disease; LUSC cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg26384229 chr12:38710491 ALG10B 0.88 15.21 0.64 4.78e-40 Bladder cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18674212 chr6:149867144 PPIL4 -0.41 -6.06 -0.31 3.64e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10089 1.000 rs3792866 chr5:127479900 A/G cg19767477 chr5:127420684 SLC12A2 -0.42 -5.73 -0.3 2.21e-8 Ileal carcinoids; LUSC cis rs117623576 0.941 rs7098334 chr10:32418501 G/T cg03047570 chr10:32398778 NA -0.6 -6.55 -0.34 2.22e-10 Anti-saccade response; LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg11235426 chr6:292522 DUSP22 -0.42 -6.03 -0.31 4.37e-9 Menopause (age at onset); LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg04944784 chr2:26401820 FAM59B 0.78 11.21 0.52 5.54e-25 Gut microbiome composition (summer); LUSC cis rs4629180 0.675 rs6742474 chr2:102091075 G/A cg01388757 chr2:102091195 RFX8 -0.36 -6.32 -0.33 8.42e-10 Chronic rhinosinusitis with nasal polyps; LUSC trans rs6982636 0.967 rs2980875 chr8:126481747 A/G cg13325919 chr3:181432053 SOX2;SOX2OT -0.31 -6.05 -0.31 3.82e-9 Lipid metabolism phenotypes; LUSC cis rs2692947 0.711 rs56791141 chr2:96587496 C/T cg23100626 chr2:96804247 ASTL 0.26 6.37 0.33 6.33e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6087771 0.642 rs6060403 chr20:30221104 C/A cg21427119 chr20:30132790 HM13 -0.38 -6.01 -0.31 4.83e-9 Subcortical brain region volumes;Putamen volume; LUSC cis rs4842666 0.915 rs11105352 chr12:90026462 G/A cg00757033 chr12:89920650 WDR51B 0.48 6.39 0.33 5.49e-10 Blood pressure; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02693249 chr1:205600567 ELK4 -0.38 -6.17 -0.32 1.94e-9 Electrocardiographic conduction measures; LUSC cis rs8017423 0.967 rs4904663 chr14:90729565 G/T cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs12618769 0.597 rs72821943 chr2:99141640 T/C cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs10489202 1.000 rs1846416 chr1:167905411 G/A cg24449463 chr1:168025552 DCAF6 -0.58 -7.16 -0.36 5.1e-12 Schizophrenia; LUSC cis rs7215564 0.908 rs35844609 chr17:78664850 T/C cg23238734 chr17:78661607 RPTOR 0.49 6.32 0.33 8.32e-10 Myopia (pathological); LUSC cis rs769267 0.629 rs7245672 chr19:19699963 T/C cg03709012 chr19:19516395 GATAD2A -0.51 -7.21 -0.37 3.67e-12 Tonsillectomy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24350392 chr17:37026147 LASP1 -0.4 -6.03 -0.31 4.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6845621 0.700 rs6449431 chr4:18894940 C/T cg12196642 chr4:18937545 NA -0.32 -5.8 -0.3 1.52e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg04267008 chr7:1944627 MAD1L1 -0.49 -7.16 -0.36 5.04e-12 Schizophrenia; LUSC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg13877915 chr19:58951672 ZNF132 0.51 7.96 0.4 2.67e-14 Uric acid clearance; LUSC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.8 0.3 1.51e-8 Intelligence (multi-trait analysis); LUSC cis rs354225 0.584 rs10188545 chr2:54831875 A/G cg26097391 chr2:54893211 SPTBN1 0.45 6.57 0.34 1.89e-10 Schizophrenia; LUSC cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 9.92 0.48 1.75e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7587476 0.531 rs35933323 chr2:215674090 T/G cg04004882 chr2:215674386 BARD1 -0.53 -7.37 -0.37 1.34e-12 Neuroblastoma; LUSC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.63 -9.91 -0.48 1.84e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg25072359 chr17:41440525 NA 0.62 9.19 0.45 4.36e-18 Menopause (age at onset); LUSC cis rs17253792 0.822 rs77761669 chr14:56034216 G/A cg01858014 chr14:56050164 KTN1 -0.75 -6.41 -0.33 4.87e-10 Putamen volume; LUSC cis rs3772130 0.583 rs7618041 chr3:121566481 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.83 13.54 0.6 1.29e-33 Cognitive performance; LUSC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg06453172 chr10:134556979 INPP5A -0.49 -6.18 -0.32 1.91e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.58 -0.43 3.52e-16 Schizophrenia; LUSC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7202877 0.656 rs4888370 chr16:75308230 T/C cg03315344 chr16:75512273 CHST6 0.44 6.32 0.33 8.38e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs1983170 0.808 rs10782962 chr1:92016210 C/A cg25838465 chr1:92012736 NA 0.43 6.05 0.31 3.82e-9 Eosinophil percentage of white cells; LUSC cis rs854765 0.583 rs9890341 chr17:17823175 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.27 0.59 1.5e-32 Total body bone mineral density; LUSC cis rs7100689 0.577 rs9420359 chr10:82054873 C/T cg01528321 chr10:82214614 TSPAN14 0.93 14.14 0.61 6.72e-36 Post bronchodilator FEV1; LUSC cis rs2742234 0.614 rs3026750 chr10:43607756 G/A cg02780029 chr10:43622663 RET -0.33 -6.14 -0.32 2.37e-9 Hirschsprung disease; LUSC cis rs7937682 0.924 rs875257 chr11:111530453 A/G cg19812747 chr11:111475976 SIK2 -0.48 -6.84 -0.35 3.87e-11 Primary sclerosing cholangitis; LUSC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg26754761 chr2:177040938 NA -0.39 -7.66 -0.39 2.09e-13 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs7215564 0.908 rs35128297 chr17:78652909 A/C cg09596252 chr17:78655493 RPTOR 0.55 5.92 0.31 7.92e-9 Myopia (pathological); LUSC cis rs11098499 0.697 rs4373140 chr4:120307698 A/G cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs9527 0.615 rs2152915 chr10:104691732 A/T cg08330031 chr10:104623503 C10orf32 0.31 5.64 0.3 3.54e-8 Arsenic metabolism; LUSC cis rs12541635 0.966 rs1603363 chr8:107031319 A/G cg10147462 chr8:107024639 NA 0.55 10.04 0.48 6.9e-21 Age of smoking initiation; LUSC cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 7.44 0.38 8.69e-13 Hip circumference adjusted for BMI; LUSC cis rs7100689 0.784 rs2153455 chr10:82139732 T/C cg01528321 chr10:82214614 TSPAN14 1.03 16.05 0.66 2.21e-43 Post bronchodilator FEV1; LUSC cis rs11122272 0.735 rs2491410 chr1:231532287 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.67 -10.65 -0.5 5.34e-23 Hemoglobin concentration; LUSC cis rs7582720 1.000 rs72936830 chr2:203769803 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.66 0.43 2.06e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7241530 0.662 rs6506751 chr18:75904506 T/C cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs4660306 1.000 rs6667191 chr1:45982844 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.43 -6.76 -0.35 6.17e-11 Homocysteine levels; LUSC cis rs1178968 1.000 rs799304 chr7:72803321 C/T cg25889504 chr7:72793014 NA 0.63 7.83 0.39 6.56e-14 Triglyceride levels; LUSC cis rs11229555 0.645 rs12272911 chr11:58183839 G/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg02782426 chr3:40428986 ENTPD3 -0.36 -7.17 -0.37 4.88e-12 Renal cell carcinoma; LUSC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg16928487 chr17:17741425 SREBF1 -0.43 -8.43 -0.42 1.03e-15 Total body bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02705895 chr4:6642252 MRFAP1 0.68 5.96 0.31 6.3e-9 Cognitive performance; LUSC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -6.9 -0.35 2.59e-11 Alzheimer's disease (late onset); LUSC cis rs7100689 0.646 rs10400045 chr10:82077032 A/G cg01528321 chr10:82214614 TSPAN14 0.82 12.36 0.56 3.74e-29 Post bronchodilator FEV1; LUSC cis rs11190604 1.000 rs3750627 chr10:102275642 G/T cg16342193 chr10:102329863 NA -0.37 -6.74 -0.35 7.17e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4561483 0.771 rs7202234 chr16:11942322 A/G cg08843971 chr16:11963173 GSPT1 0.44 6.55 0.34 2.12e-10 Testicular germ cell tumor; LUSC trans rs61931739 0.782 rs1197569 chr12:34186733 A/T cg13010199 chr12:38710504 ALG10B 0.42 6.67 0.34 1.08e-10 Morning vs. evening chronotype; LUSC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg21724239 chr8:58056113 NA 0.57 5.78 0.3 1.71e-8 Developmental language disorder (linguistic errors); LUSC cis rs7582180 0.903 rs13008568 chr2:100896242 A/G cg08017756 chr2:100939284 LONRF2 -0.36 -6.01 -0.31 4.77e-9 Intelligence (multi-trait analysis); LUSC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg20243544 chr17:37824526 PNMT 0.5 7.11 0.36 6.96e-12 Asthma; LUSC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg03060546 chr3:49711283 APEH -0.6 -7.21 -0.37 3.74e-12 Menarche (age at onset); LUSC cis rs478304 0.934 rs1193692 chr11:65504069 A/C cg05805236 chr11:65401703 PCNXL3 0.4 6.76 0.35 6.32e-11 Acne (severe); LUSC cis rs9303401 0.659 rs12150536 chr17:56640834 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.63 0.6 6.06e-34 Cognitive test performance; LUSC cis rs1003719 1.000 rs1003719 chr21:38491095 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.66 10.4 0.49 4.09e-22 Eye color traits; LUSC cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg21545522 chr1:205238299 TMCC2 0.47 8.79 0.43 8.29e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.0 -0.58 1.54e-31 Platelet count; LUSC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg02018176 chr4:1364513 KIAA1530 0.5 8.57 0.42 3.88e-16 Longevity; LUSC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg08847533 chr14:75593920 NEK9 -0.79 -13.4 -0.59 4.55e-33 Height; LUSC cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg23158103 chr7:148848205 ZNF398 -0.46 -7.4 -0.38 1.11e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7202877 0.611 rs56092808 chr16:75312716 A/T cg03315344 chr16:75512273 CHST6 0.45 6.37 0.33 6.29e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6546537 0.562 rs7565783 chr2:69750113 C/T cg10773587 chr2:69614142 GFPT1 -0.58 -9.65 -0.47 1.36e-19 Serum thyroid-stimulating hormone levels; LUSC cis rs9527 0.590 rs11191540 chr10:104822809 G/C cg05855489 chr10:104503620 C10orf26 0.53 8.01 0.4 1.98e-14 Arsenic metabolism; LUSC trans rs417096 1.000 rs417096 chr6:39727833 G/A cg17457912 chr17:1617102 C17orf91 -0.31 -6.05 -0.31 3.89e-9 Hypospadias; LUSC cis rs9388451 0.839 rs9401845 chr6:126104118 A/G cg10911889 chr6:126070802 HEY2 0.42 6.39 0.33 5.59e-10 Brugada syndrome; LUSC cis rs3106136 0.967 rs2306803 chr4:95161996 C/T cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.06 -0.31 3.75e-9 Capecitabine sensitivity; LUSC cis rs7147624 0.766 rs11158597 chr14:65913536 T/G cg03016385 chr14:66212404 NA -0.83 -9.44 -0.46 6.63e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1865721 0.958 rs72977878 chr18:73193037 T/G cg26385618 chr18:73139727 C18orf62 -0.48 -8.1 -0.41 1.04e-14 Intelligence; LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg22903657 chr4:1355424 KIAA1530 -0.35 -5.77 -0.3 1.78e-8 Obesity-related traits; LUSC cis rs9467773 0.595 rs2451736 chr6:26620544 G/A cg09904177 chr6:26538194 HMGN4 0.65 11.67 0.54 1.3e-26 Intelligence (multi-trait analysis); LUSC trans rs1493916 0.870 rs1389531 chr18:31386616 C/T cg27147174 chr7:100797783 AP1S1 -0.64 -10.48 -0.5 2.08e-22 Life satisfaction; LUSC cis rs2273669 0.667 rs12202145 chr6:109357829 A/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs7267979 1.000 rs453329 chr20:25440593 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.09 0.74 1.98e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs919433 0.679 rs6757632 chr2:198530266 C/T cg00792783 chr2:198669748 PLCL1 0.42 5.66 0.3 3.23e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs9611519 0.894 rs9623320 chr22:41478482 G/A cg13813247 chr22:41461852 NA -0.36 -6.43 -0.33 4.54e-10 Neuroticism; LUSC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg27170947 chr2:26402098 FAM59B -0.72 -10.53 -0.5 1.43e-22 Gut microbiome composition (summer); LUSC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg05347473 chr6:146136440 FBXO30 0.58 10.1 0.48 4.16e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.863 rs3733525 chr4:120447048 A/G cg09307838 chr4:120376055 NA 0.73 10.22 0.49 1.58e-21 Corneal astigmatism; LUSC trans rs9650657 0.538 rs11250093 chr8:10798828 C/T cg06636001 chr8:8085503 FLJ10661 0.54 7.56 0.38 3.81e-13 Neuroticism; LUSC cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.05 -0.44 1.17e-17 Schizophrenia; LUSC cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.52e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11644478 chr21:40555479 PSMG1 0.95 18.49 0.71 4.54e-53 Cognitive function; LUSC cis rs35883536 0.647 rs10875317 chr1:101045438 G/T cg06223162 chr1:101003688 GPR88 -0.48 -9.09 -0.45 8.68e-18 Monocyte count; LUSC cis rs4919694 0.536 rs12414777 chr10:104697781 C/T cg04362960 chr10:104952993 NT5C2 0.88 11.23 0.52 4.85e-25 Arsenic metabolism; LUSC cis rs2797160 1.000 rs983543 chr6:126005767 G/A cg05901451 chr6:126070800 HEY2 -0.58 -8.59 -0.43 3.43e-16 Endometrial cancer; LUSC cis rs4076764 0.846 rs12036398 chr1:163422204 C/T cg24596788 chr1:163392923 NA 0.37 6.24 0.32 1.36e-9 Motion sickness; LUSC cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg03146154 chr1:46216737 IPP 0.55 8.24 0.41 3.92e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2935183 1 rs2935183 chr17:45607572 T/G cg08085267 chr17:45401833 C17orf57 0.59 9.62 0.47 1.69e-19 Multiple sclerosis or amyotrophic lateral sclerosis; LUSC trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -7.06 -0.36 9.85e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs11098499 0.542 rs10440343 chr4:120309787 G/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg19748678 chr4:122722346 EXOSC9 0.74 11.19 0.52 6.82e-25 Type 2 diabetes; LUSC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg13206674 chr6:150067644 NUP43 0.61 9.92 0.48 1.65e-20 Lung cancer; LUSC trans rs10506458 1.000 rs73127086 chr12:63415626 G/A cg22491629 chr6:157744540 C6orf35 -0.85 -10.38 -0.49 4.48e-22 Hemostatic factors and hematological phenotypes; LUSC cis rs12200782 0.505 rs7765920 chr6:26514771 C/T cg05738196 chr6:26577821 NA 0.51 5.97 0.31 6.01e-9 Small cell lung carcinoma; LUSC cis rs66887589 0.777 rs1814815 chr4:120258091 C/T cg13609457 chr4:120235615 NA 0.37 5.84 0.3 1.24e-8 Diastolic blood pressure; LUSC cis rs3960554 0.709 rs73138006 chr7:75769990 T/C cg17325771 chr7:75508891 RHBDD2 -0.41 -5.73 -0.3 2.25e-8 Eotaxin levels; LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg19318889 chr4:1322082 MAEA 0.53 8.69 0.43 1.67e-16 Obesity-related traits; LUSC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg27165867 chr14:105738592 BRF1 -0.52 -7.45 -0.38 7.91e-13 Mean platelet volume;Platelet distribution width; LUSC trans rs7313075 0.714 rs76127916 chr12:102740904 T/C cg12813724 chr1:26690537 ZNF683 0.69 5.96 0.31 6.47e-9 Height; LUSC cis rs9300255 0.722 rs12298826 chr12:123829028 A/G cg13010344 chr12:123464640 ARL6IP4 0.49 6.44 0.33 4.06e-10 Neutrophil percentage of white cells; LUSC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg19812747 chr11:111475976 SIK2 -0.55 -8.15 -0.41 7.59e-15 Primary sclerosing cholangitis; LUSC cis rs782590 0.774 rs2627773 chr2:55900459 A/G cg18811423 chr2:55921094 PNPT1 0.88 15.78 0.65 2.66e-42 Metabolic syndrome; LUSC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg10802521 chr3:52805072 NEK4 -0.56 -9.29 -0.45 1.99e-18 Bipolar disorder; LUSC cis rs11098499 0.615 rs59867181 chr4:120556467 C/T cg09307838 chr4:120376055 NA -0.58 -8.86 -0.44 4.9e-17 Corneal astigmatism; LUSC cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg01884057 chr2:25150051 NA 0.44 10.37 0.49 5.07e-22 Body mass index; LUSC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg24399712 chr22:39784796 NA -0.62 -11.46 -0.53 7.19e-26 Intelligence (multi-trait analysis); LUSC cis rs7712401 0.601 rs442911 chr5:122325551 T/C cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs7772486 0.654 rs4896829 chr6:145953675 T/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.78 -0.35 5.52e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17042849 chr6:26104293 HIST1H4C -0.41 -6.28 -0.32 1.07e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2842992 0.747 rs4709379 chr6:160227530 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.15 16.42 0.67 7.64e-45 Age-related macular degeneration (geographic atrophy); LUSC cis rs7589342 0.839 rs1465639 chr2:106439181 T/C cg14210321 chr2:106509881 NCK2 -0.53 -7.98 -0.4 2.44e-14 Addiction; LUSC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.36 0.42 1.67e-15 Hemoglobin concentration; LUSC cis rs7959452 0.718 rs10878963 chr12:69717166 T/G cg14784868 chr12:69753453 YEATS4 0.5 7.74 0.39 1.17e-13 Blood protein levels; LUSC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg26441486 chr22:50317300 CRELD2 0.51 7.78 0.39 9.05e-14 Schizophrenia; LUSC cis rs4555082 0.957 rs2816609 chr14:105720803 A/C cg10792982 chr14:105748885 BRF1 0.46 7.83 0.39 6.35e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg03806693 chr22:41940476 POLR3H 0.9 12.43 0.56 2.06e-29 Vitiligo; LUSC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg27532560 chr4:187881888 NA -0.43 -6.97 -0.36 1.75e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.67 -11.43 -0.53 9.13e-26 Menarche (age at onset); LUSC cis rs10078 0.571 rs890973 chr5:471494 T/C cg08916839 chr5:415575 AHRR 0.76 7.1 0.36 7.48e-12 Fat distribution (HIV); LUSC cis rs11690935 1.000 rs6721680 chr2:172543913 G/T cg13550731 chr2:172543902 DYNC1I2 0.89 14.76 0.63 2.73e-38 Schizophrenia; LUSC cis rs554111 0.656 rs964466 chr1:21375163 T/G cg01072550 chr1:21505969 NA 0.39 5.94 0.31 7.13e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs4954585 0.683 rs13004902 chr2:137027680 A/G cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.65e-13 Colorectal cancer; LUSC cis rs12618769 0.597 rs12622341 chr2:99074680 A/T cg10123293 chr2:99228465 UNC50 0.45 7.45 0.38 8.3e-13 Bipolar disorder; LUSC cis rs983392 0.709 rs7932740 chr11:59976111 G/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.92 -0.31 8.06e-9 Alzheimer's disease (late onset); LUSC trans rs1908814 0.516 rs60176945 chr8:11796674 T/C cg15556689 chr8:8085844 FLJ10661 0.58 8.63 0.43 2.48e-16 Neuroticism; LUSC cis rs73001065 0.711 rs58489806 chr19:19456917 C/T cg03709012 chr19:19516395 GATAD2A 0.85 6.79 0.35 5.19e-11 LDL cholesterol; LUSC cis rs61935443 0.778 rs78522691 chr12:95267340 G/T cg21533806 chr12:95267307 NA 0.52 6.6 0.34 1.59e-10 Schizophrenia; LUSC cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg00383909 chr3:49044727 WDR6 1.43 10.52 0.5 1.52e-22 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs8032315 0.965 rs1894400 chr15:91428955 C/T cg05469396 chr15:91419421 FURIN -0.42 -6.66 -0.34 1.15e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs763121 1.000 rs763121 chr22:38879940 C/T cg06022373 chr22:39101656 GTPBP1 -0.63 -9.93 -0.48 1.57e-20 Menopause (age at onset); LUSC cis rs11625487 0.645 rs8006951 chr14:77965304 G/A cg20045696 chr14:77926864 AHSA1 0.44 6.06 0.31 3.73e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC trans rs9388451 0.868 rs10457467 chr6:126045148 T/A cg05039488 chr6:79577232 IRAK1BP1 -0.58 -9.17 -0.45 5.07e-18 Brugada syndrome; LUSC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.86 0.35 3.37e-11 Tonsillectomy; LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.72e-10 Bipolar disorder; LUSC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC trans rs1741464 0.555 rs229581 chr14:65271650 A/G cg22491548 chr7:128000861 PRRT4 -0.28 -6.01 -0.31 4.92e-9 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs13006833 0.694 rs291444 chr2:191176223 T/C cg21644426 chr2:191273491 MFSD6 0.43 6.16 0.32 2.13e-9 Urinary metabolites; LUSC cis rs360798 0.512 rs1906198 chr2:62946658 C/T cg17519650 chr2:63277830 OTX1 0.53 7.45 0.38 7.87e-13 Coronary artery disease; LUSC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg09640425 chr7:158790006 NA -0.52 -8.38 -0.42 1.45e-15 Facial morphology (factor 20); LUSC cis rs7107174 1.000 rs2512533 chr11:77968674 A/C cg02023728 chr11:77925099 USP35 0.52 7.2 0.37 4.11e-12 Testicular germ cell tumor; LUSC cis rs28374715 0.532 rs3204853 chr15:41689166 C/A cg18705301 chr15:41695430 NDUFAF1 -1.04 -22.52 -0.78 5.53e-69 Ulcerative colitis; LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg16647868 chr5:131706066 SLC22A5 -0.38 -5.71 -0.3 2.53e-8 Breast cancer; LUSC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg21951975 chr1:209979733 IRF6 0.57 6.87 0.35 3.14e-11 Coronary artery disease; LUSC cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg06547715 chr2:218990976 CXCR2 0.33 6.47 0.33 3.57e-10 Ulcerative colitis; LUSC cis rs7481584 0.624 rs413368 chr11:3047646 C/G cg08508325 chr11:3079039 CARS 0.36 8.18 0.41 5.9e-15 Calcium levels; LUSC cis rs10193935 0.786 rs10178087 chr2:42409631 C/A cg27598129 chr2:42591480 NA -0.59 -7.88 -0.4 4.72e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg12615879 chr12:58013172 SLC26A10 -0.29 -5.94 -0.31 7.18e-9 Multiple sclerosis; LUSC cis rs2932538 0.922 rs2273369 chr1:113072477 A/G cg22162597 chr1:113214053 CAPZA1 0.73 10.43 0.5 3.18e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs2688608 0.901 rs2459446 chr10:75601596 C/T cg17411546 chr10:75410026 SYNPO2L 0.4 5.67 0.3 3.1e-8 Inflammatory bowel disease; LUSC trans rs1005277 0.638 rs1005278 chr10:38218748 G/A cg17830980 chr10:43048298 ZNF37B 0.46 6.56 0.34 2.03e-10 Extrinsic epigenetic age acceleration; LUSC cis rs4664304 0.652 rs2221808 chr2:160870944 T/C cg23995753 chr2:160760732 LY75 -0.3 -5.67 -0.3 3.16e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg26597838 chr10:835615 NA 1.23 16.43 0.67 6.93e-45 Eosinophil percentage of granulocytes; LUSC cis rs9788682 0.948 rs59683676 chr15:78833453 T/C cg06917634 chr15:78832804 PSMA4 -0.59 -7.25 -0.37 2.85e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg16325326 chr1:53192061 ZYG11B 0.88 15.1 0.64 1.28e-39 Monocyte count; LUSC cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg10621924 chr7:39171070 POU6F2 0.45 6.61 0.34 1.48e-10 IgG glycosylation; LUSC cis rs3126085 0.867 rs12748016 chr1:152197235 T/C cg26876637 chr1:152193138 HRNR -0.45 -6.29 -0.33 9.91e-10 Atopic dermatitis; LUSC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg01097406 chr16:89675127 NA 0.37 7.18 0.37 4.42e-12 Vitiligo; LUSC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg06221963 chr1:154839813 KCNN3 -0.59 -13.47 -0.59 2.55e-33 Prostate cancer; LUSC cis rs9296092 0.538 rs56205713 chr6:33517510 A/G cg13560919 chr6:33536144 NA -0.82 -15.73 -0.65 4.02e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg13319975 chr6:146136371 FBXO30 -0.54 -8.13 -0.41 8.34e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.626 rs6667103 chr1:153064438 A/G cg07796016 chr1:152779584 LCE1C -0.41 -6.28 -0.32 1.06e-9 Inflammatory skin disease; LUSC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg15664640 chr17:80829946 TBCD 0.51 8.92 0.44 3.1e-17 Breast cancer; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg07242783 chr1:28052377 FAM76A -0.48 -6.75 -0.35 6.42e-11 Cognitive function;Information processing speed; LUSC cis rs1030877 0.960 rs3792050 chr2:105902255 T/C cg02079111 chr2:105885981 TGFBRAP1 -0.74 -13.39 -0.59 5.13e-33 Obesity-related traits; LUSC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg03804128 chr16:635623 NA 0.32 6.26 0.32 1.19e-9 Height; LUSC cis rs10845606 1.000 rs11055013 chr12:12829037 T/C cg09462578 chr12:12878428 APOLD1 -0.54 -6.54 -0.34 2.27e-10 Systemic lupus erythematosus; LUSC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg00990874 chr7:1149470 C7orf50 -0.58 -7.73 -0.39 1.3e-13 Bronchopulmonary dysplasia; LUSC cis rs6087990 0.842 rs6119279 chr20:31330612 A/G cg13636640 chr20:31349939 DNMT3B 0.98 21.42 0.76 1.15e-64 Ulcerative colitis; LUSC cis rs6012953 1.000 rs6020586 chr20:49155663 T/C cg13958625 chr20:49123093 NA 0.3 6.69 0.34 9.65e-11 Vitiligo; LUSC cis rs791888 0.667 rs2762520 chr10:89414845 A/G cg13926569 chr10:89418898 PAPSS2 -0.29 -5.67 -0.3 3.14e-8 Magnesium levels; LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg22963979 chr7:1858916 MAD1L1 -0.69 -11.68 -0.54 1.14e-26 Bipolar disorder and schizophrenia; LUSC cis rs10875595 0.836 rs7703869 chr5:140666494 C/T cg24830062 chr5:140700576 TAF7 -0.52 -6.29 -0.33 1e-9 Pulmonary function decline; LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2885056 0.783 rs12459941 chr19:10666112 A/G cg04833646 chr19:10679720 CDKN2D -1.17 -17.35 -0.69 1.52e-48 Red cell distribution width; LUSC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg02915803 chr1:1606292 LOC728661;CDK11B 0.38 5.96 0.31 6.24e-9 Body mass index; LUSC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg13395646 chr4:1353034 KIAA1530 -0.6 -9.38 -0.46 1.05e-18 Longevity; LUSC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg11062466 chr8:58055876 NA 0.49 6.45 0.33 3.88e-10 Developmental language disorder (linguistic errors); LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.96 -0.4 2.78e-14 Lymphocyte counts; LUSC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.09 0.32 3.1e-9 Personality dimensions; LUSC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg20933634 chr6:27740509 NA 0.43 6.06 0.31 3.76e-9 Parkinson's disease; LUSC trans rs72674100 1.000 rs4632666 chr4:97990707 A/T cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs3857536 0.813 rs9354403 chr6:66943426 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg15704280 chr7:45808275 SEPT13 -0.46 -6.34 -0.33 7.57e-10 HDL cholesterol; LUSC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg02018176 chr4:1364513 KIAA1530 -0.57 -9.88 -0.48 2.25e-20 Obesity-related traits; LUSC cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg14844989 chr11:31128820 NA -0.37 -5.74 -0.3 2.1e-8 Bone mineral density (spine); LUSC cis rs2839186 0.967 rs17176131 chr21:47705237 T/C cg05896524 chr21:47604654 C21orf56 0.4 5.92 0.31 7.87e-9 Testicular germ cell tumor; LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T cg26110710 chr13:88323607 SLITRK5 -0.39 -6.23 -0.32 1.41e-9 Leprosy; LUSC cis rs6547741 1.000 rs1528402 chr2:27857517 G/A cg27432699 chr2:27873401 GPN1 0.78 14.13 0.61 7.32e-36 Oral cavity cancer; LUSC cis rs1018836 0.828 rs10091275 chr8:91559751 A/G cg16814680 chr8:91681699 NA -0.69 -11.18 -0.52 7.14e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.576 rs7660951 chr4:98651581 T/A cg05340658 chr4:99064831 C4orf37 0.57 8.61 0.43 2.84e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs12995491 1.000 rs12995491 chr2:88527414 C/T cg18302933 chr2:88491318 NA 0.35 6.89 0.35 2.86e-11 Response to metformin (IC50); LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg00106254 chr7:1943704 MAD1L1 -0.39 -5.68 -0.3 2.95e-8 Bipolar disorder and schizophrenia; LUSC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 6.02 0.31 4.59e-9 Tonsillectomy; LUSC cis rs7607369 0.536 rs4674345 chr2:219671598 A/G cg02176678 chr2:219576539 TTLL4 -0.5 -8.8 -0.43 7.58e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg00750074 chr16:89608354 SPG7 -0.58 -10.2 -0.49 1.94e-21 Multiple myeloma (IgH translocation); LUSC cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.73e-15 Homoarginine levels; LUSC cis rs56399783 0.614 rs73047368 chr7:2766396 G/T cg14895029 chr7:2775587 GNA12 0.54 5.85 0.3 1.2e-8 Childhood ear infection; LUSC cis rs7106204 0.514 rs34587986 chr11:24253053 T/C ch.11.24196551F chr11:24239977 NA 0.92 10.2 0.49 1.98e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg06873352 chr17:61820015 STRADA 0.72 12.86 0.58 4.98e-31 Prudent dietary pattern; LUSC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -8.53 -0.42 5.23e-16 Hemoglobin concentration; LUSC cis rs17401966 1.000 rs17401924 chr1:10384439 A/G cg19773385 chr1:10388646 KIF1B -0.54 -8.38 -0.42 1.5e-15 Hepatocellular carcinoma; LUSC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg04155289 chr7:94953770 PON1 -0.34 -5.75 -0.3 2.02e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7572644 0.664 rs12620151 chr2:28102704 T/A cg27432699 chr2:27873401 GPN1 0.53 6.5 0.33 3.01e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg02018176 chr4:1364513 KIAA1530 0.51 8.74 0.43 1.14e-16 Obesity-related traits; LUSC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg19346786 chr7:2764209 NA -0.38 -6.58 -0.34 1.82e-10 Height; LUSC cis rs34779708 0.931 rs7079498 chr10:35375344 C/T cg04310649 chr10:35416472 CREM -0.44 -6.85 -0.35 3.54e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs35883536 0.605 rs2133118 chr1:101034337 C/T cg09408571 chr1:101003634 GPR88 -0.29 -5.74 -0.3 2.13e-8 Monocyte count; LUSC cis rs1790761 0.667 rs591434 chr11:67337814 C/T cg23188684 chr11:67383651 NA 0.35 6.19 0.32 1.76e-9 Mean corpuscular volume; LUSC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.86 -0.31 1.13e-8 Alzheimer's disease (late onset); LUSC cis rs7666738 0.546 rs10440329 chr4:98903735 C/T cg03676636 chr4:99064102 C4orf37 0.31 6.22 0.32 1.47e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4363385 0.818 rs3806222 chr1:153002606 C/T cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs2806561 0.765 rs1738470 chr1:23511911 G/A cg19743168 chr1:23544995 NA 0.39 7.68 0.39 1.83e-13 Height; LUSC cis rs9611565 0.802 rs132916 chr22:41806768 C/G cg03806693 chr22:41940476 POLR3H 0.81 11.21 0.52 5.69e-25 Vitiligo; LUSC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.16 0.41 7.01e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.57 0.38 3.61e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10178409 1 rs10178409 chr2:73855507 G/T cg20560298 chr2:73613845 ALMS1 -0.42 -5.93 -0.31 7.39e-9 Urinary metabolites; LUSC cis rs7100689 0.646 rs7089003 chr10:82124155 T/C cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs9560113 0.806 rs9560112 chr13:112183320 A/G cg14154082 chr13:112174009 NA 0.39 7.89 0.4 4.29e-14 Menarche (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12041467 chr19:45873960 ERCC2 -0.44 -6.4 -0.33 5.15e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7678296 0.649 rs77896458 chr4:37237843 A/G cg06805348 chr4:37245195 KIAA1239 0.57 5.88 0.31 9.88e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04371633 chr14:65381025 CHURC1 0.43 6.54 0.34 2.33e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg04511125 chr2:88470314 THNSL2 0.96 9.4 0.46 8.95e-19 Plasma clusterin levels; LUSC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg20608306 chr11:116969690 SIK3 -0.38 -6.34 -0.33 7.55e-10 Blood protein levels; LUSC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg20302533 chr7:39170763 POU6F2 0.51 8.15 0.41 7.56e-15 IgG glycosylation; LUSC cis rs4595586 0.545 rs1375796 chr12:39410592 G/T cg26384229 chr12:38710491 ALG10B 0.54 7.65 0.39 2.2e-13 Morning vs. evening chronotype; LUSC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg16586182 chr3:47516702 SCAP -0.5 -7.83 -0.39 6.35e-14 Colorectal cancer; LUSC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg22535103 chr8:58192502 C8orf71 -0.82 -10.09 -0.48 4.5e-21 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 6.83e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs11690935 0.959 rs6745143 chr2:172650382 G/A cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.68 -0.63 5.51e-38 Schizophrenia; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.41 -6.74 -0.35 6.9e-11 Longevity;Endometriosis; LUSC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs8114671 0.836 rs4911461 chr20:33629993 A/C cg07148914 chr20:33460835 GGT7 -0.45 -6.67 -0.34 1.07e-10 Height; LUSC cis rs791888 0.858 rs2180968 chr10:89418730 A/C cg13926569 chr10:89418898 PAPSS2 0.35 6.87 0.35 3.08e-11 Magnesium levels; LUSC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.67 -10.62 -0.5 6.81e-23 Menarche (age at onset); LUSC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg11871910 chr12:69753446 YEATS4 0.86 14.9 0.63 7.81e-39 Blood protein levels; LUSC cis rs754466 0.580 rs10824571 chr10:79531931 G/A cg17075019 chr10:79541650 NA -0.77 -12.25 -0.56 9.55e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12956009 0.583 rs4452038 chr18:44856529 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.1 0.32 2.87e-9 Educational attainment (years of education); LUSC trans rs853679 0.825 rs8180562 chr6:28141460 G/A cg06606381 chr12:133084897 FBRSL1 -0.66 -7.14 -0.36 5.96e-12 Depression; LUSC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg12615879 chr12:58013172 SLC26A10 -0.27 -5.74 -0.3 2.11e-8 Multiple sclerosis; LUSC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg17971929 chr21:40555470 PSMG1 0.79 13.82 0.6 1.1e-34 Cognitive function; LUSC cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.62 0.43 2.78e-16 Menopause (age at onset); LUSC cis rs9811920 0.809 rs7649349 chr3:99725629 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.69 -0.34 9.47e-11 Axial length; LUSC cis rs208520 0.909 rs9354411 chr6:67019930 A/G cg07460842 chr6:66804631 NA 0.89 9.06 0.44 1.1e-17 Exhaled nitric oxide output; LUSC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg19592336 chr6:28129416 ZNF389 0.47 6.16 0.32 2.05e-9 Depression; LUSC cis rs9814567 1.000 rs2373865 chr3:134291556 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs72781680 0.611 rs74661620 chr2:24365260 C/A cg06627628 chr2:24431161 ITSN2 -0.67 -7.97 -0.4 2.53e-14 Lymphocyte counts; LUSC trans rs11098499 0.863 rs28718422 chr4:120466304 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.83 0.35 3.91e-11 Corneal astigmatism; LUSC cis rs4132509 0.744 rs10927068 chr1:243923452 C/T cg21452805 chr1:244014465 NA 0.63 6.94 0.35 2.07e-11 RR interval (heart rate); LUSC cis rs4906332 0.966 rs2065016 chr14:103879656 T/A cg04998671 chr14:104000505 TRMT61A -0.46 -7.2 -0.37 4.12e-12 Coronary artery disease; LUSC cis rs698813 0.555 rs7605771 chr2:44479778 G/A cg00619915 chr2:44497795 NA -0.53 -7.52 -0.38 4.96e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs6580649 0.941 rs72644843 chr12:48465061 A/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05986781 chr7:127291658 SND1 0.45 6.2 0.32 1.67e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg07424592 chr7:64974309 NA 0.68 5.99 0.31 5.51e-9 Diabetic kidney disease; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.05 0.64 1.96e-39 Platelet count; LUSC cis rs2286503 0.839 rs4722189 chr7:22860474 G/A cg11367502 chr7:22862612 TOMM7 0.44 6.01 0.31 4.92e-9 Fibrinogen; LUSC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg15369054 chr17:80825471 TBCD -0.63 -9.74 -0.47 6.68e-20 Breast cancer; LUSC cis rs2658782 0.724 rs2605629 chr11:93264037 C/G cg15737290 chr11:93063684 CCDC67 -0.65 -8.14 -0.41 7.77e-15 Pulmonary function decline; LUSC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg05347473 chr6:146136440 FBXO30 0.63 10.51 0.5 1.6e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs6499755 1.000 rs6499755 chr16:55341135 T/C cg02859129 chr16:55357253 IRX6 0.36 6.1 0.32 2.86e-9 Hypospadias; LUSC cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.53 0.46 3.45e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7829975 0.684 rs474892 chr8:8596731 G/T cg18904891 chr8:8559673 CLDN23 -0.38 -5.66 -0.3 3.33e-8 Mood instability; LUSC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg26039829 chr8:22132926 PIWIL2 0.45 8.29 0.41 2.81e-15 Hypertriglyceridemia; LUSC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg01579765 chr21:45077557 HSF2BP -0.57 -12.3 -0.56 6.36e-29 Mean corpuscular volume; LUSC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.27 0.32 1.15e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3942852 0.955 rs6485809 chr11:48112468 C/T cg20307385 chr11:47447363 PSMC3 0.51 5.98 0.31 5.72e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs10186029 0.509 rs13417355 chr2:213943030 C/T cg08319019 chr2:214017104 IKZF2 -0.41 -6.0 -0.31 5.17e-9 Systemic sclerosis; LUSC cis rs2898290 0.622 rs978802 chr8:11343278 A/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.86 -0.35 3.36e-11 Systolic blood pressure; LUSC cis rs751728 0.965 rs2013381 chr6:33763837 C/T cg25922239 chr6:33757077 LEMD2 0.55 8.26 0.41 3.56e-15 Crohn's disease; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.37 0.46 1.15e-18 Bipolar disorder; LUSC trans rs6502050 0.835 rs3935128 chr17:80113414 T/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg13628971 chr7:2884303 GNA12 0.5 6.93 0.35 2.21e-11 Height; LUSC trans rs11098499 0.909 rs11723757 chr4:120299669 C/T cg25214090 chr10:38739885 LOC399744 0.55 7.93 0.4 3.28e-14 Corneal astigmatism; LUSC cis rs6570726 0.967 rs413880 chr6:145804822 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.3 0.33 9.47e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18404041 chr3:52824283 ITIH1 -0.53 -10.22 -0.49 1.66e-21 Electroencephalogram traits; LUSC cis rs6714710 0.603 rs35505530 chr2:98506910 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.18e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.64 14.3 0.62 1.54e-36 Hemoglobin concentration; LUSC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg22903471 chr2:27725779 GCKR -0.41 -6.96 -0.36 1.78e-11 Total body bone mineral density; LUSC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg04546413 chr19:29218101 NA 0.71 11.0 0.52 3.19e-24 Methadone dose in opioid dependence; LUSC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg02187348 chr16:89574699 SPG7 0.61 10.03 0.48 7.29e-21 Multiple myeloma (IgH translocation); LUSC cis rs11587400 0.572 rs2268699 chr1:115227896 G/T cg12756093 chr1:115239321 AMPD1 0.45 6.95 0.36 1.98e-11 Autism; LUSC trans rs3857536 0.704 rs4710570 chr6:66890244 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC cis rs7572733 0.534 rs6760891 chr2:198768166 T/G cg00792783 chr2:198669748 PLCL1 0.46 6.2 0.32 1.68e-9 Dermatomyositis; LUSC cis rs6542838 0.641 rs4851176 chr2:99534859 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.99 -0.31 5.55e-9 Fear of minor pain; LUSC cis rs9888739 0.800 rs11859300 chr16:31355895 G/T cg15817542 chr16:31343056 ITGAM -0.53 -7.27 -0.37 2.63e-12 Systemic lupus erythematosus; LUSC cis rs6920965 0.561 rs9401851 chr6:126181956 T/C cg05901451 chr6:126070800 HEY2 -0.49 -7.31 -0.37 1.93e-12 High light scatter reticulocyte count; LUSC cis rs10771431 0.817 rs17202253 chr12:9361850 A/G cg00504896 chr12:9437009 LOC642846 -0.39 -5.8 -0.3 1.58e-8 Breast size; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg22875332 chr1:76189707 ACADM -0.41 -6.2 -0.32 1.65e-9 Daytime sleep phenotypes; LUSC cis rs1790761 0.933 rs1790752 chr11:67202044 G/A cg24690094 chr11:67383802 NA -0.33 -6.08 -0.32 3.35e-9 Mean corpuscular volume; LUSC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg13531842 chr10:38383804 ZNF37A -0.46 -7.23 -0.37 3.4e-12 Extrinsic epigenetic age acceleration; LUSC cis rs7584330 0.868 rs7569197 chr2:238383073 A/G cg14458575 chr2:238380390 NA 0.68 11.41 0.53 1.06e-25 Prostate cancer; LUSC cis rs2286885 1.000 rs741022 chr9:129252113 C/G cg15282417 chr9:129245246 FAM125B 0.39 6.71 0.34 8.41e-11 Intraocular pressure; LUSC cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.39 0.56 2.99e-29 Motion sickness; LUSC cis rs72781680 0.898 rs56216411 chr2:23934533 G/A cg08917208 chr2:24149416 ATAD2B 1.0 10.16 0.49 2.55e-21 Lymphocyte counts; LUSC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.11 -0.32 2.77e-9 Major depressive disorder; LUSC cis rs6076065 0.723 rs2424541 chr20:23386776 T/C cg11657817 chr20:23433608 CST11 0.42 8.01 0.4 1.94e-14 Facial morphology (factor 15, philtrum width); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24506149 chr1:39339048 MYCBP -0.41 -6.14 -0.32 2.32e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg00677455 chr12:58241039 CTDSP2 0.7 10.75 0.51 2.41e-23 Intelligence (multi-trait analysis); LUSC cis rs12928939 0.517 rs12934512 chr16:71965230 C/G cg03805757 chr16:71968109 PKD1L3 -0.64 -9.8 -0.47 4.31e-20 Post bronchodilator FEV1; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg01238044 chr22:24384105 GSTT1 -0.72 -11.53 -0.53 4.15e-26 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg25342872 chr17:79175132 AZI1 -0.47 -8.09 -0.4 1.15e-14 Frontotemporal dementia; LUSC cis rs13385 0.769 rs10060203 chr5:139599319 T/G cg26211634 chr5:139558579 C5orf32 0.45 6.81 0.35 4.63e-11 Atrial fibrillation; LUSC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg17971929 chr21:40555470 PSMG1 0.79 13.73 0.6 2.61e-34 Cognitive function; LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg19318889 chr4:1322082 MAEA 0.44 7.27 0.37 2.49e-12 Obesity-related traits; LUSC cis rs12477438 0.834 rs1563107 chr2:99701276 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.92 13.7 0.6 3.27e-34 Chronic sinus infection; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21755257 chr18:23806431 TAF4B 0.81 7.56 0.38 3.89e-13 Cognitive performance; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05968270 chr1:65533502 NA 0.44 6.63 0.34 1.35e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1577917 0.682 rs1173417 chr6:86403941 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 7.66 0.39 1.98e-13 Response to antipsychotic treatment; LUSC cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg02527881 chr3:46936655 PTH1R 0.42 7.5 0.38 5.92e-13 Colorectal cancer; LUSC cis rs9921338 0.961 rs4315353 chr16:11414160 T/C cg00044050 chr16:11439710 C16orf75 0.48 6.53 0.34 2.5e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs17604090 0.793 rs10226095 chr7:29690059 A/G cg19413766 chr7:29689036 LOC646762 0.57 7.45 0.38 8e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7614311 0.681 rs6796317 chr3:63927739 A/G cg22134162 chr3:63841271 THOC7 -0.46 -5.84 -0.3 1.25e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.56 0.57 6.67e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg23066280 chr7:158032496 PTPRN2 0.39 6.7 0.34 8.75e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs963731 0.571 rs4670270 chr2:39230351 G/A cg04010122 chr2:39346883 SOS1 -0.79 -5.73 -0.3 2.2e-8 Corticobasal degeneration; LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs72781680 0.950 rs56128748 chr2:24126809 T/G cg20701182 chr2:24300061 SF3B14 0.57 6.17 0.32 1.99e-9 Lymphocyte counts; LUSC trans rs4332037 0.552 rs11773627 chr7:2002733 A/G cg10840412 chr1:235813424 GNG4 0.51 7.05 0.36 1.01e-11 Bipolar disorder; LUSC cis rs6952809 0.504 rs1978169 chr7:2434522 G/A cg23289794 chr7:2394357 EIF3B -0.7 -9.52 -0.46 3.74e-19 Multiple sclerosis; LUSC trans rs1997103 0.911 rs17777 chr7:55380765 T/C cg20935933 chr6:143382018 AIG1 0.49 6.88 0.35 3.04e-11 QRS interval (sulfonylurea treatment interaction); LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg24503407 chr1:205819492 PM20D1 0.84 14.7 0.63 4.36e-38 Menarche (age at onset); LUSC cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg01256987 chr12:42539512 GXYLT1 -0.46 -8.72 -0.43 1.35e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2197308 0.549 rs10785517 chr12:38577992 G/T cg26384229 chr12:38710491 ALG10B 0.57 8.41 0.42 1.22e-15 Morning vs. evening chronotype; LUSC cis rs57590327 0.508 rs7621968 chr3:81951460 A/G cg07356753 chr3:81810745 GBE1 -0.54 -7.63 -0.39 2.52e-13 Extraversion; LUSC cis rs11167764 1.000 rs10057309 chr5:141479870 T/C cg08523384 chr5:141488047 NDFIP1 -0.51 -7.41 -0.38 1.04e-12 Crohn's disease; LUSC cis rs12579753 0.879 rs35087297 chr12:82133398 C/T cg07988820 chr12:82153109 PPFIA2 -0.45 -6.44 -0.33 4.21e-10 Resting heart rate; LUSC trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.3 0.37 2.06e-12 Motion sickness; LUSC trans rs1325195 0.920 rs2816199 chr1:179158932 G/A cg11624085 chr17:8464688 MYH10 0.4 6.53 0.34 2.44e-10 IgE grass sensitization; LUSC cis rs1729951 0.575 rs835641 chr3:136703474 G/T cg21827317 chr3:136751795 NA 0.39 7.12 0.36 6.45e-12 Neuroticism; LUSC cis rs8017423 0.872 rs7492857 chr14:90684867 T/G cg04374321 chr14:90722782 PSMC1 -0.67 -10.06 -0.48 5.63e-21 Mortality in heart failure; LUSC cis rs10203711 0.933 rs10180937 chr2:239597184 A/G cg14580085 chr2:239553406 NA 0.43 7.17 0.37 4.81e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg13736514 chr6:26305472 NA -0.46 -9.26 -0.45 2.64e-18 Educational attainment; LUSC cis rs240764 0.717 rs1039031 chr6:101161812 A/G cg09795085 chr6:101329169 ASCC3 0.4 5.68 0.3 2.91e-8 Neuroticism; LUSC cis rs7917772 0.582 rs10786691 chr10:104364652 G/A cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.26e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.2 -0.32 1.67e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg08280861 chr8:58055591 NA 0.53 5.73 0.3 2.22e-8 Developmental language disorder (linguistic errors); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26943658 chr12:105501532 KIAA1033 -0.45 -6.41 -0.33 4.93e-10 Electrocardiographic conduction measures; LUSC cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg16606324 chr3:10149918 C3orf24 0.44 7.01 0.36 1.36e-11 Alzheimer's disease; LUSC cis rs11105298 0.891 rs10777185 chr12:89921275 C/T cg00757033 chr12:89920650 WDR51B 0.59 10.45 0.5 2.65e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6700896 0.500 rs1892535 chr1:66097181 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.52 6.07 0.32 3.56e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs701145 0.585 rs1713843 chr3:153786394 C/G cg17054900 chr3:154042577 DHX36 -0.55 -5.92 -0.31 8.07e-9 Coronary artery disease; LUSC cis rs11039100 1.000 rs12792952 chr11:5826813 C/G cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.05 0.55 5.3e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1953600 0.668 rs3122586 chr10:81950326 C/T cg00277334 chr10:82204260 NA 0.5 7.95 0.4 2.97e-14 Sarcoidosis; LUSC trans rs11764590 0.715 rs11766468 chr7:2082604 G/A cg25206134 chr2:45395956 NA 0.59 6.06 0.31 3.59e-9 Neuroticism; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg05552183 chr6:42928497 GNMT 0.51 8.5 0.42 6.22e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg24675658 chr1:53192096 ZYG11B -0.7 -11.68 -0.54 1.2e-26 Monocyte count; LUSC cis rs1801251 0.896 rs4973561 chr2:233687337 C/G cg08000102 chr2:233561755 GIGYF2 -0.64 -10.48 -0.5 2.17e-22 Coronary artery disease; LUSC cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg14584255 chr6:163149320 PACRG;PARK2 -0.35 -6.65 -0.34 1.22e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10876993 0.928 rs7136269 chr12:58075937 G/A cg15848620 chr12:58087721 OS9 -0.57 -8.12 -0.41 8.89e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs12421382 0.614 rs12575538 chr11:109390966 C/A cg11473876 chr11:109292803 C11orf87 0.34 5.74 0.3 2.15e-8 Schizophrenia; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg10389385 chr7:77427730 TMEM60;PHTF2 0.39 6.0 0.31 5.14e-9 Schizophrenia; LUSC cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg18105134 chr13:113819100 PROZ -0.64 -9.64 -0.47 1.41e-19 Platelet distribution width; LUSC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.56 -8.8 -0.43 7.66e-17 Total body bone mineral density; LUSC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg12463550 chr7:65579703 CRCP 0.48 7.2 0.37 4.03e-12 Aortic root size; LUSC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg06636001 chr8:8085503 FLJ10661 -0.54 -7.97 -0.4 2.6e-14 Joint mobility (Beighton score); LUSC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg18252515 chr7:66147081 NA -1.22 -13.35 -0.59 7.04e-33 Diabetic kidney disease; LUSC cis rs1691799 0.867 rs1027400 chr12:66760922 A/T cg16791601 chr12:66731901 HELB -0.68 -12.0 -0.55 7.95e-28 White blood cell count (basophil); LUSC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg26677194 chr12:130822605 PIWIL1 -0.54 -8.39 -0.42 1.37e-15 Menopause (age at onset); LUSC trans rs6030 0.957 rs916438 chr1:169499659 A/T cg16792071 chr10:134842795 NA -0.27 -5.97 -0.31 6.07e-9 Uric acid levels; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg09041756 chr7:5570314 ACTB 0.64 6.04 0.31 4.14e-9 Myocardial infarction; LUSC cis rs877282 0.891 rs10904557 chr10:797490 C/T cg17470449 chr10:769945 NA -0.47 -6.62 -0.34 1.45e-10 Uric acid levels; LUSC cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg00071950 chr4:10020882 SLC2A9 0.58 9.96 0.48 1.27e-20 Bone mineral density; LUSC cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg26384229 chr12:38710491 ALG10B 0.86 14.36 0.62 9.24e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg04234412 chr22:24373322 LOC391322 0.94 17.97 0.7 5.42e-51 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3540 0.554 rs34650360 chr15:91059017 T/C cg10434728 chr15:90938212 IQGAP1 -0.45 -9.02 -0.44 1.46e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg03929089 chr4:120376271 NA 0.68 7.58 0.38 3.49e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs921968 0.541 rs664514 chr2:219329819 A/G cg02176678 chr2:219576539 TTLL4 0.74 14.33 0.62 1.24e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg25072359 chr17:41440525 NA 0.66 9.45 0.46 6.13e-19 Menopause (age at onset); LUSC cis rs1577917 0.958 rs12195776 chr6:86488599 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.8 -0.35 4.83e-11 Response to antipsychotic treatment; LUSC cis rs1595825 0.891 rs73054827 chr2:198649905 G/A cg10547527 chr2:198650123 BOLL -0.51 -5.98 -0.31 5.64e-9 Ulcerative colitis; LUSC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg01017244 chr2:74357527 NA 0.69 13.25 0.59 1.7e-32 Gestational age at birth (maternal effect); LUSC cis rs9318086 0.648 rs4067969 chr13:24469120 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.43 6.43 0.33 4.3e-10 Myopia (pathological); LUSC cis rs11785400 1.000 rs3824208 chr8:143743653 C/G cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg22029157 chr1:209979665 IRF6 0.77 8.9 0.44 3.52e-17 Cleft lip with or without cleft palate; LUSC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg06238570 chr21:40685208 BRWD1 -0.6 -9.91 -0.48 1.81e-20 Cognitive function; LUSC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg13770153 chr20:60521292 NA -0.64 -8.89 -0.44 3.86e-17 Body mass index; LUSC cis rs12997796 0.556 rs34353387 chr2:86974834 A/C cg25203885 chr2:87302643 LOC285074 -0.8 -8.16 -0.41 6.99e-15 Schizophrenia; LUSC cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg05347473 chr6:146136440 FBXO30 0.51 8.45 0.42 9.4e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs11997175 0.670 rs34985841 chr8:33661889 C/A ch.8.33884649F chr8:33765107 NA 0.5 7.92 0.4 3.56e-14 Body mass index; LUSC cis rs7107174 0.688 rs2063724 chr11:78133077 T/C cg27205649 chr11:78285834 NARS2 -0.49 -5.7 -0.3 2.61e-8 Testicular germ cell tumor; LUSC cis rs12295403 0.691 rs9705036 chr11:18686916 A/G cg09887367 chr11:18690185 NA 0.32 6.63 0.34 1.35e-10 Ovarian reserve; LUSC cis rs35264875 0.846 rs72930625 chr11:68867120 T/A cg02660097 chr11:68866761 NA 0.42 5.78 0.3 1.68e-8 Blond vs. brown hair color; LUSC trans rs2587949 0.615 rs1485249 chr3:4238075 G/A cg15139668 chr4:4577005 NA -0.4 -5.98 -0.31 5.86e-9 Periodontitis (DPAL); LUSC cis rs7739264 0.602 rs2223362 chr6:19778171 C/A cg02404759 chr6:19790362 NA -0.43 -6.6 -0.34 1.59e-10 Endometriosis; LUSC cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg07424592 chr7:64974309 NA -0.4 -5.74 -0.3 2.16e-8 Calcium levels; LUSC cis rs10416265 0.528 rs3786932 chr19:33620488 T/A cg17764715 chr19:33622953 WDR88 0.59 6.62 0.34 1.46e-10 Bone properties (heel); LUSC cis rs950776 0.518 rs62008194 chr15:78813805 G/T cg06917634 chr15:78832804 PSMA4 0.83 15.05 0.64 1.89e-39 Sudden cardiac arrest; LUSC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.0 0.36 1.45e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1568889 1.000 rs61889054 chr11:28333000 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.56 7.46 0.38 7.65e-13 Bipolar disorder; LUSC cis rs6076065 0.723 rs6083087 chr20:23341529 C/T cg11657817 chr20:23433608 CST11 0.43 8.15 0.41 7.44e-15 Facial morphology (factor 15, philtrum width); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg22438376 chr5:141348885 RNF14 0.39 5.94 0.31 6.98e-9 Triglycerides; LUSC cis rs11864453 0.647 rs2550035 chr16:72113416 C/G cg16558253 chr16:72132732 DHX38 -0.36 -5.78 -0.3 1.75e-8 Fibrinogen levels; LUSC cis rs4129585 0.665 rs10098073 chr8:143309504 A/C cg16886403 chr8:143471632 TSNARE1 0.46 6.64 0.34 1.29e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs738321 0.690 rs11570750 chr22:38513138 G/A cg25457927 chr22:38595422 NA -0.32 -6.11 -0.32 2.8e-9 Breast cancer; LUSC cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.94 0.36 2.02e-11 Schizophrenia; LUSC trans rs2243480 1.000 rs160633 chr7:65528228 T/C cg10756647 chr7:56101905 PSPH 0.86 8.63 0.43 2.62e-16 Diabetic kidney disease; LUSC cis rs9633740 1.000 rs1902660 chr10:82263683 G/C cg01528321 chr10:82214614 TSPAN14 1.07 12.16 0.55 1.97e-28 Post bronchodilator FEV1; LUSC cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs4073416 0.504 rs6573612 chr14:65912829 G/A cg03016385 chr14:66212404 NA -0.38 -5.68 -0.3 3e-8 N-glycan levels; LUSC cis rs12681287 0.511 rs9297923 chr8:87548989 T/C cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg12463550 chr7:65579703 CRCP 0.5 7.18 0.37 4.47e-12 Aortic root size; LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs7814319 0.933 rs7002575 chr8:97242124 G/A cg20787634 chr8:97240163 UQCRB -0.34 -5.92 -0.31 7.94e-9 Lung function (FVC); LUSC cis rs2228479 0.541 rs9806913 chr16:89953773 A/G cg00800038 chr16:89945340 TCF25 -0.63 -6.68 -0.34 1.02e-10 Skin colour saturation; LUSC cis rs12989701 0.778 rs7584040 chr2:127863224 C/T cg08168897 chr2:127865431 BIN1 0.53 7.32 0.37 1.82e-12 Alzheimer's disease (late onset); LUSC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg05844789 chr1:228464394 OBSCN 0.35 6.77 0.35 5.78e-11 Diastolic blood pressure; LUSC cis rs9644630 0.897 rs28671342 chr8:19352420 C/T cg01280390 chr8:19363452 CSGALNACT1 -0.39 -7.25 -0.37 2.85e-12 Oropharynx cancer; LUSC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg12463550 chr7:65579703 CRCP 0.63 5.7 0.3 2.63e-8 Gout; LUSC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg03452623 chr4:187889614 NA -0.85 -17.32 -0.69 2.01e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg18876405 chr7:65276391 NA 0.76 13.74 0.6 2.4e-34 Aortic root size; LUSC cis rs9479482 0.967 rs9479478 chr6:150354608 T/G cg00432049 chr6:150390894 ULBP3 -0.27 -5.93 -0.31 7.75e-9 Alopecia areata; LUSC cis rs2274273 0.870 rs1109170 chr14:55785788 A/C cg04306507 chr14:55594613 LGALS3 0.56 12.99 0.58 1.58e-31 Protein biomarker; LUSC cis rs1949733 0.656 rs2631762 chr4:8423122 A/T cg11789530 chr4:8429930 ACOX3 0.59 9.11 0.45 7.8e-18 Response to antineoplastic agents; LUSC cis rs367943 0.712 rs13188946 chr5:112722855 C/T cg12552261 chr5:112820674 MCC 0.37 6.11 0.32 2.78e-9 Type 2 diabetes; LUSC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg08125733 chr17:73851984 WBP2 0.49 6.9 0.35 2.64e-11 White matter hyperintensity burden; LUSC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.94 0.31 7.01e-9 Intelligence (multi-trait analysis); LUSC cis rs9747201 1.000 rs62078307 chr17:80090053 G/T cg18209359 chr17:80159595 CCDC57 0.4 6.61 0.34 1.52e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs709400 0.859 rs7693 chr14:104023704 C/T cg24130564 chr14:104152367 KLC1 -0.51 -7.24 -0.37 3.07e-12 Body mass index; LUSC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.69 0.54 1.09e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9818941 0.740 rs11713363 chr3:157828322 A/G cg08654915 chr3:157813417 NA 0.29 7.09 0.36 8.22e-12 Height; LUSC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg25067162 chr17:41277974 BRCA1;NBR2 -0.36 -5.95 -0.31 6.72e-9 Menopause (age at onset); LUSC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg09509183 chr1:209979624 IRF6 0.52 6.21 0.32 1.61e-9 Cleft lip with or without cleft palate; LUSC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs10089 1.000 rs6887847 chr5:127473807 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.89 12.55 0.57 7.43e-30 Ileal carcinoids; LUSC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg06640241 chr16:89574553 SPG7 0.87 15.32 0.64 1.63e-40 Multiple myeloma (IgH translocation); LUSC cis rs7772486 0.777 rs1546966 chr6:146386018 G/T cg05347473 chr6:146136440 FBXO30 0.39 6.19 0.32 1.75e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs644799 0.710 rs564480 chr11:95561741 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.84 13.13 0.58 4.92e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3126085 0.935 rs4845741 chr1:152183474 A/G cg26876637 chr1:152193138 HRNR 0.43 6.18 0.32 1.91e-9 Atopic dermatitis; LUSC cis rs11785693 0.862 rs11778306 chr8:4988269 A/C cg26367366 chr8:4980734 NA 0.73 8.62 0.43 2.72e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg25258033 chr6:167368657 RNASET2 -0.46 -7.52 -0.38 5.24e-13 Crohn's disease; LUSC cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.91 -0.31 8.46e-9 Intelligence (multi-trait analysis); LUSC cis rs9921338 0.961 rs8043692 chr16:11426957 C/T cg00044050 chr16:11439710 C16orf75 -0.49 -6.56 -0.34 2.03e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs926938 0.552 rs360613 chr1:115394864 C/G cg12756093 chr1:115239321 AMPD1 0.47 7.23 0.37 3.33e-12 Autism; LUSC cis rs7107174 1.000 rs2511156 chr11:77971167 G/C cg02023728 chr11:77925099 USP35 0.51 7.12 0.36 6.52e-12 Testicular germ cell tumor; LUSC cis rs524023 0.914 rs11231845 chr11:64407419 G/A cg07220939 chr11:64358617 SLC22A12 -0.22 -5.73 -0.3 2.27e-8 Urate levels in obese individuals; LUSC cis rs2439831 0.850 rs16963953 chr15:44081719 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.89 8.94 0.44 2.72e-17 Lung cancer in ever smokers; LUSC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.73 13.3 0.59 1.1e-32 Intelligence (multi-trait analysis); LUSC cis rs314370 0.951 rs6706 chr7:100471044 C/T cg18683606 chr7:100471612 SRRT 0.45 5.96 0.31 6.4e-9 Resting heart rate; LUSC cis rs7615316 0.763 rs10935465 chr3:142271797 A/C cg16271453 chr3:142027066 XRN1 -0.37 -6.3 -0.33 9.46e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg23093090 chr10:104574429 C10orf26 -0.39 -7.34 -0.37 1.62e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09358240 chr1:185126285 C1orf25;C1orf26 -0.38 -5.95 -0.31 6.83e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03678139 chr1:41832388 NA 0.41 5.99 0.31 5.42e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs9860340 0.652 rs57087351 chr3:87637535 G/A cg03644585 chr7:884825 UNC84A 0.42 6.03 0.31 4.35e-9 Electroencephalographic traits in alcoholism; LUSC cis rs9549367 0.713 rs3024776 chr13:113827075 A/G cg18105134 chr13:113819100 PROZ 0.75 10.77 0.51 2.12e-23 Platelet distribution width; LUSC trans rs208520 1.000 rs12199876 chr6:66989469 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.88 0.55 2.21e-27 Exhaled nitric oxide output; LUSC cis rs7359276 1 rs7359276 chr15:78892661 C/T cg06917634 chr15:78832804 PSMA4 0.49 6.35 0.33 7.15e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg06808227 chr14:105710500 BRF1 -0.69 -10.72 -0.51 2.94e-23 Mean platelet volume;Platelet distribution width; LUSC cis rs72960926 0.744 rs72950524 chr6:74900108 G/A cg03266952 chr6:74778945 NA -0.76 -6.05 -0.31 3.85e-9 Metabolite levels (MHPG); LUSC trans rs66573146 0.634 rs56097119 chr4:7018692 C/G cg07817883 chr1:32538562 TMEM39B 1.09 10.08 0.48 4.88e-21 Granulocyte percentage of myeloid white cells; LUSC cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg26061582 chr7:22766209 IL6 -0.47 -5.98 -0.31 5.58e-9 Lung cancer; LUSC cis rs2625529 0.878 rs71395051 chr15:72239789 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.51 -0.38 5.28e-13 Red blood cell count; LUSC cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg26384229 chr12:38710491 ALG10B 0.96 18.39 0.71 1.14e-52 Heart rate; LUSC cis rs6977660 0.941 rs5017197 chr7:19819967 T/A cg05791153 chr7:19748676 TWISTNB 0.53 5.86 0.31 1.08e-8 Thyroid stimulating hormone; LUSC cis rs58785573 0.504 rs13151185 chr4:38609196 G/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.55 7.84 0.39 6.17e-14 Lymphocyte percentage of white cells; LUSC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg17971929 chr21:40555470 PSMG1 -0.49 -7.24 -0.37 3.07e-12 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26417871 chr18:18691918 ROCK1 -0.4 -6.04 -0.31 4.03e-9 Electrocardiographic conduction measures; LUSC cis rs10779751 1.000 rs1135172 chr1:11301714 C/T cg08854313 chr1:11322531 MTOR -0.85 -14.02 -0.61 2e-35 Body mass index; LUSC cis rs35123781 0.696 rs356433 chr5:139071193 C/T cg10513866 chr5:139070639 NA 0.53 9.41 0.46 8.2e-19 Schizophrenia; LUSC trans rs17685 0.753 rs6951808 chr7:75772413 A/G cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7605827 0.930 rs10176967 chr2:15686086 G/T cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg22655196 chr4:3374909 RGS12 0.33 6.36 0.33 6.75e-10 Serum sulfate level; LUSC cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.96 -0.31 6.3e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs4319547 0.915 rs7316734 chr12:123117425 A/G cg05707623 chr12:122985044 ZCCHC8 -0.63 -8.34 -0.42 2.01e-15 Body mass index; LUSC trans rs61931739 0.517 rs7139189 chr12:34319757 T/C cg13010199 chr12:38710504 ALG10B 0.47 7.33 0.37 1.75e-12 Morning vs. evening chronotype; LUSC cis rs2479724 0.905 rs2251274 chr6:41839438 T/G cg17623882 chr6:41773611 USP49 -0.65 -11.06 -0.52 1.94e-24 Menarche (age at onset); LUSC cis rs1775715 0.737 rs2778672 chr10:32122419 T/C cg26784012 chr10:32216390 ARHGAP12 0.44 7.29 0.37 2.23e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1062746 0.545 rs3815947 chr16:87359648 C/T cg02258303 chr16:87377426 FBXO31 -0.49 -7.62 -0.38 2.58e-13 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg07424592 chr7:64974309 NA 0.42 5.92 0.31 7.97e-9 Calcium levels; LUSC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg15445000 chr17:37608096 MED1 -0.39 -6.77 -0.35 5.69e-11 Glomerular filtration rate (creatinine); LUSC cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg06064525 chr11:970664 AP2A2 -0.49 -10.74 -0.51 2.66e-23 Alzheimer's disease (late onset); LUSC cis rs66887589 0.837 rs6534135 chr4:120406302 A/G cg09307838 chr4:120376055 NA 0.48 7.2 0.37 4.07e-12 Diastolic blood pressure; LUSC cis rs2797160 0.905 rs1418640 chr6:125999866 G/A cg05901451 chr6:126070800 HEY2 -0.58 -8.7 -0.43 1.5e-16 Endometrial cancer; LUSC cis rs56091001 0.528 rs9616387 chr22:50313219 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -8.01 -0.4 1.88e-14 Acne (severe); LUSC cis rs8027181 0.839 rs10459647 chr15:73035241 T/C cg25632853 chr15:73088954 NA 0.31 6.4 0.33 5.34e-10 Triglyceride levels; LUSC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg04234412 chr22:24373322 LOC391322 -0.86 -14.01 -0.61 2.2e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2281845 0.507 rs10800760 chr1:201100439 G/A cg06714761 chr1:201096289 NA 0.43 7.73 0.39 1.25e-13 Permanent tooth development; LUSC cis rs6599077 1.000 rs6766178 chr3:40098109 T/C cg13683864 chr3:40499215 RPL14 -0.59 -7.38 -0.37 1.29e-12 Sleep-related phenotypes; LUSC trans rs853679 1.000 rs9986596 chr6:28219661 G/A cg06606381 chr12:133084897 FBRSL1 -0.58 -6.68 -0.34 9.77e-11 Depression; LUSC trans rs7843479 1.000 rs17615788 chr8:21814739 C/T cg10573190 chr2:85843190 USP39 -0.42 -6.05 -0.31 3.78e-9 Mean corpuscular volume; LUSC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg25358565 chr5:93447407 FAM172A -1.06 -12.04 -0.55 5.75e-28 Diabetic retinopathy; LUSC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg12463550 chr7:65579703 CRCP 0.53 7.66 0.39 2.06e-13 Aortic root size; LUSC trans rs11098499 0.954 rs59394118 chr4:120295551 A/G cg25214090 chr10:38739885 LOC399744 0.56 8.09 0.4 1.08e-14 Corneal astigmatism; LUSC cis rs9467773 1.000 rs12526680 chr6:26550954 A/G cg11502198 chr6:26597334 ABT1 0.6 9.33 0.45 1.56e-18 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg11766577 chr21:47581405 C21orf56 -0.54 -8.46 -0.42 8.25e-16 Testicular germ cell tumor; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg22166914 chr1:53195759 ZYG11B 0.5 7.93 0.4 3.23e-14 Monocyte count; LUSC cis rs7149337 0.869 rs10137445 chr14:51694416 G/A cg23942311 chr14:51606299 NA 0.48 10.76 0.51 2.17e-23 Cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17841838 chr19:3626645 C19orf29 -0.52 -6.83 -0.35 3.98e-11 Bipolar disorder and schizophrenia; LUSC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg16928487 chr17:17741425 SREBF1 0.44 8.61 0.43 2.91e-16 Total body bone mineral density; LUSC cis rs11690935 0.959 rs76324055 chr2:172620150 T/A cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.26 -0.62 2.3e-36 Schizophrenia; LUSC trans rs6951245 0.554 rs4724294 chr7:1139695 G/A cg13565492 chr6:43139072 SRF -0.73 -10.85 -0.51 1.03e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg04025307 chr7:1156635 C7orf50 0.37 5.69 0.3 2.73e-8 Longevity;Endometriosis; LUSC cis rs9403521 1.000 rs117303301 chr6:143999003 C/T cg18240653 chr6:144019428 PHACTR2 -0.51 -6.16 -0.32 2.13e-9 Obesity-related traits; LUSC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg16606324 chr3:10149918 C3orf24 0.65 9.65 0.47 1.38e-19 Alzheimer's disease; LUSC cis rs8017423 0.904 rs2149647 chr14:90769539 C/T cg14092571 chr14:90743983 NA 0.35 5.65 0.3 3.36e-8 Mortality in heart failure; LUSC cis rs7618501 1.000 rs9859153 chr3:49807085 G/T cg24110177 chr3:50126178 RBM5 -0.41 -6.58 -0.34 1.79e-10 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg16145915 chr7:1198662 ZFAND2A -0.72 -14.91 -0.63 6.88e-39 Longevity;Endometriosis; LUSC cis rs11676348 0.935 rs2230054 chr2:219000310 C/T cg00012203 chr2:219082015 ARPC2 -0.55 -8.63 -0.43 2.49e-16 Ulcerative colitis; LUSC cis rs881375 0.967 rs758959 chr9:123676699 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.96 0.31 6.32e-9 Rheumatoid arthritis; LUSC cis rs16910800 1.000 rs2449442 chr11:23197362 C/T cg20040320 chr11:23191996 NA 0.44 6.58 0.34 1.81e-10 Cancer; LUSC cis rs1983891 1.000 rs9296365 chr6:41535379 A/G cg20194872 chr6:41519635 FOXP4 0.37 6.61 0.34 1.48e-10 Prostate cancer; LUSC cis rs7100689 0.784 rs10736341 chr10:82061206 C/G cg01528321 chr10:82214614 TSPAN14 0.98 14.61 0.62 1.03e-37 Post bronchodilator FEV1; LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg18758796 chr5:131593413 PDLIM4 0.42 6.76 0.35 6.09e-11 Breast cancer; LUSC cis rs600231 0.708 rs1784100 chr11:65249227 T/C cg21890820 chr11:65308645 LTBP3 0.49 7.22 0.37 3.51e-12 Bone mineral density; LUSC cis rs17030434 0.911 rs115948674 chr4:154742052 G/T cg14289246 chr4:154710475 SFRP2 -0.55 -7.32 -0.37 1.85e-12 Electrocardiographic conduction measures; LUSC cis rs1908814 0.516 rs13281077 chr8:11794814 C/T cg21775007 chr8:11205619 TDH 0.47 6.66 0.34 1.11e-10 Neuroticism; LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.59 -0.34 1.68e-10 Menopause (age at onset); LUSC cis rs2624839 0.704 rs12632110 chr3:50224225 A/G cg24110177 chr3:50126178 RBM5 0.43 6.7 0.34 8.65e-11 Intelligence (multi-trait analysis); LUSC cis rs4664308 0.505 rs1037694 chr2:161028992 A/G cg03641300 chr2:160917029 PLA2R1 -0.46 -7.45 -0.38 7.91e-13 Idiopathic membranous nephropathy; LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs4704187 0.687 rs4447960 chr5:74361857 C/A cg03227963 chr5:74354835 NA 0.33 7.02 0.36 1.23e-11 Response to amphetamines; LUSC cis rs12681287 0.604 rs41469550 chr8:87406544 G/T cg27223183 chr8:87520930 FAM82B 0.55 7.49 0.38 6.24e-13 Caudate activity during reward; LUSC cis rs500891 1.000 rs1171134 chr6:84204477 G/A cg08257003 chr6:84140564 ME1 -0.32 -6.55 -0.34 2.22e-10 Platelet-derived growth factor BB levels; LUSC cis rs479844 0.617 rs12146493 chr11:65547333 G/A cg27068330 chr11:65405492 SIPA1 0.48 6.53 0.34 2.45e-10 Allergic disease (asthma, hay fever or eczema);Atopic march;Atopic dermatitis; LUSC cis rs7267979 0.899 rs2179459 chr20:25456141 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 17.09 0.68 1.66e-47 Liver enzyme levels (alkaline phosphatase); LUSC cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg10556349 chr10:835070 NA 0.58 6.58 0.34 1.82e-10 Eosinophil percentage of granulocytes; LUSC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg12463550 chr7:65579703 CRCP 0.53 7.71 0.39 1.48e-13 Aortic root size; LUSC trans rs1493916 1.000 rs1493916 chr18:31392577 T/G cg27147174 chr7:100797783 AP1S1 -0.65 -10.41 -0.49 3.75e-22 Life satisfaction; LUSC cis rs10871290 0.801 rs3851726 chr16:74471644 G/C cg01733217 chr16:74700730 RFWD3 -0.54 -7.75 -0.39 1.12e-13 Breast cancer; LUSC cis rs35146811 0.844 rs4729576 chr7:99692594 G/A cg22906224 chr7:99728672 NA 0.56 8.05 0.4 1.52e-14 Coronary artery disease; LUSC cis rs9650315 0.789 rs57887485 chr8:57201243 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.31 0.37 1.93e-12 Height; LUSC trans rs9886428 0.967 rs10087038 chr8:14115672 A/G cg19037007 chr20:741798 C20orf54 -0.39 -6.04 -0.31 4.02e-9 IgG glycosylation; LUSC trans rs62238980 0.614 rs79221399 chr22:32368918 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.01 -0.31 4.85e-9 Childhood ear infection; LUSC cis rs9943753 0.525 rs7957928 chr12:109835975 C/G cg19025524 chr12:109796872 NA -0.38 -6.81 -0.35 4.43e-11 HDL cholesterol; LUSC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg20243544 chr17:37824526 PNMT -0.46 -5.71 -0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs7100689 0.784 rs3120977 chr10:82075324 C/G cg01528321 chr10:82214614 TSPAN14 0.97 14.68 0.63 5.28e-38 Post bronchodilator FEV1; LUSC cis rs208520 0.633 rs7738469 chr6:66807446 T/C cg07460842 chr6:66804631 NA -1.11 -17.48 -0.69 4.68e-49 Exhaled nitric oxide output; LUSC cis rs3741151 0.686 rs7938391 chr11:73221957 A/G cg17517138 chr11:73019481 ARHGEF17 0.77 7.25 0.37 2.98e-12 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4253772 0.938 rs41378347 chr22:46636976 G/A cg24881330 chr22:46731750 TRMU 0.62 5.84 0.3 1.26e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs7586879 0.789 rs13035239 chr2:25134000 T/A cg01884057 chr2:25150051 NA 0.42 8.53 0.42 5.01e-16 Body mass index; LUSC cis rs9467773 1.000 rs9461259 chr6:26504835 C/A cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.97e-18 Intelligence (multi-trait analysis); LUSC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.85 -0.31 1.15e-8 Alzheimer's disease (late onset); LUSC cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg14530993 chr4:882597 GAK 0.64 6.73 0.35 7.19e-11 Intelligence (multi-trait analysis); LUSC cis rs7582720 1.000 rs72932789 chr2:203699379 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs12200560 0.505 rs211172 chr6:97070691 C/A cg06623918 chr6:96969491 KIAA0776 0.49 7.07 0.36 8.98e-12 Coronary heart disease; LUSC cis rs6076065 0.683 rs1419010 chr20:23365254 G/C cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg04553112 chr3:125709451 NA -0.51 -5.83 -0.3 1.31e-8 Blood pressure (smoking interaction); LUSC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg27532560 chr4:187881888 NA -0.37 -6.09 -0.32 3.16e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.02 0.44 1.46e-17 Motion sickness; LUSC cis rs3020736 0.500 rs7292241 chr22:42492063 G/A cg04733989 chr22:42467013 NAGA -0.63 -9.79 -0.47 4.63e-20 Autism spectrum disorder or schizophrenia; LUSC trans rs1499614 1.000 rs2707832 chr7:66136549 C/T cg10756647 chr7:56101905 PSPH 0.84 8.53 0.42 5.19e-16 Gout; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg24575065 chr7:72972219 BCL7B 0.35 6.22 0.32 1.5e-9 Metabolite levels (Pyroglutamine); LUSC cis rs7481584 0.624 rs440130 chr11:3051476 A/G cg05729581 chr11:3078854 CARS 0.39 5.7 0.3 2.57e-8 Calcium levels; LUSC cis rs2115630 1.000 rs55646601 chr15:85323568 G/T cg11189052 chr15:85197271 WDR73 -0.46 -6.66 -0.34 1.16e-10 P wave terminal force; LUSC cis rs7267979 0.934 rs2261753 chr20:25262291 G/A cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.18e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9660992 0.649 rs12128229 chr1:205268014 C/A cg21545522 chr1:205238299 TMCC2 0.49 9.0 0.44 1.68e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg14784868 chr12:69753453 YEATS4 0.82 13.98 0.61 2.89e-35 Blood protein levels; LUSC cis rs6840360 0.571 rs4696270 chr4:152498289 G/A cg22705602 chr4:152727874 NA -0.34 -6.82 -0.35 4.21e-11 Intelligence (multi-trait analysis); LUSC cis rs8092503 0.859 rs35509548 chr18:52472408 A/G cg12377874 chr18:52495404 RAB27B 0.33 5.97 0.31 6.2e-9 Childhood body mass index; LUSC cis rs911119 0.955 rs61035931 chr20:23595714 A/G cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg20503657 chr10:835505 NA 0.86 12.13 0.55 2.58e-28 Eosinophil percentage of granulocytes; LUSC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg04414720 chr1:150670196 GOLPH3L 0.51 7.93 0.4 3.39e-14 Melanoma; LUSC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg12403142 chr1:92012408 NA -0.39 -6.27 -0.32 1.12e-9 Breast cancer; LUSC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg23172400 chr8:95962367 TP53INP1 -0.35 -6.49 -0.33 3.08e-10 Type 2 diabetes; LUSC cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg09184832 chr6:79620586 NA -0.42 -6.87 -0.35 3.21e-11 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg06740227 chr12:86229804 RASSF9 -0.43 -6.99 -0.36 1.47e-11 Major depressive disorder; LUSC cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg21361702 chr7:150065534 REPIN1 -0.59 -8.43 -0.42 1.06e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg10811474 chr19:8428787 ANGPTL4 -0.39 -5.97 -0.31 6.07e-9 HDL cholesterol; LUSC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg07716408 chr11:68623521 NA -0.33 -6.41 -0.33 4.99e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1865760 0.964 rs1324084 chr6:25915134 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.78 0.35 5.41e-11 Height; LUSC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg10018233 chr7:150070692 REPIN1 0.39 6.81 0.35 4.52e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg11752832 chr7:134001865 SLC35B4 0.51 7.75 0.39 1.09e-13 Mean platelet volume; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03934478 chr11:495069 RNH1 0.86 9.38 0.46 1.06e-18 Body mass index; LUSC cis rs9457247 1.000 rs393558 chr6:167397750 A/C cg25258033 chr6:167368657 RNASET2 0.47 7.84 0.39 6.15e-14 Crohn's disease; LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg26335602 chr6:28129616 ZNF389 0.49 6.56 0.34 2e-10 Parkinson's disease; LUSC cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg05347473 chr6:146136440 FBXO30 0.42 7.22 0.37 3.47e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg23630131 chr7:65973040 NA -0.21 -5.83 -0.3 1.33e-8 Aortic root size; LUSC cis rs4363385 0.818 rs377768 chr1:153016594 T/C cg25856811 chr1:152973957 SPRR3 -0.34 -5.79 -0.3 1.62e-8 Inflammatory skin disease; LUSC cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg08213375 chr14:104286397 PPP1R13B 0.47 8.5 0.42 6.58e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs10871290 0.507 rs3851731 chr16:74485788 C/T cg01733217 chr16:74700730 RFWD3 0.57 8.15 0.41 7.27e-15 Breast cancer; LUSC cis rs9443645 0.810 rs7753531 chr6:79789996 A/C cg05283184 chr6:79620031 NA -0.55 -11.41 -0.53 1.05e-25 Intelligence (multi-trait analysis); LUSC cis rs12776158 0.901 rs60110374 chr10:71217090 C/T cg12610070 chr10:71211762 TSPAN15 -0.46 -5.91 -0.31 8.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs3768617 0.510 rs2296300 chr1:183099701 G/A ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC trans rs11933661 0.528 rs1022008 chr4:130966269 C/G cg14421548 chr9:77111779 RORB 0.4 5.98 0.31 5.87e-9 Alcohol dependence; LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg22638593 chr5:131593259 PDLIM4 0.43 6.57 0.34 1.94e-10 Blood metabolite levels; LUSC cis rs6076065 0.962 rs1003417 chr20:23348007 T/A cg11657817 chr20:23433608 CST11 0.43 8.45 0.42 9.37e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs11098499 0.954 rs12506546 chr4:120301618 T/C cg09307838 chr4:120376055 NA 0.79 11.4 0.53 1.23e-25 Corneal astigmatism; LUSC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg26441486 chr22:50317300 CRELD2 0.46 6.73 0.35 7.54e-11 Schizophrenia; LUSC cis rs926938 0.527 rs360679 chr1:115494121 G/T cg01522456 chr1:115632236 TSPAN2 -0.41 -6.42 -0.33 4.76e-10 Autism; LUSC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg23985595 chr17:80112537 CCDC57 0.33 6.28 0.33 1.05e-9 Life satisfaction; LUSC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg22800045 chr5:56110881 MAP3K1 0.76 9.84 0.47 3.24e-20 Initial pursuit acceleration; LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg09177884 chr7:1199841 ZFAND2A -0.48 -6.35 -0.33 6.9e-10 Longevity;Endometriosis; LUSC cis rs1185460 0.967 rs2509121 chr11:118928253 C/T cg23280166 chr11:118938394 VPS11 0.46 6.98 0.36 1.62e-11 Coronary artery disease; LUSC trans rs4927850 1.000 rs7625570 chr3:195747398 A/G cg21051086 chr3:73046214 PPP4R2 -0.53 -8.02 -0.4 1.85e-14 Pancreatic cancer; LUSC cis rs11971779 0.680 rs111461944 chr7:139077903 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg08088566 chr11:430123 ANO9 0.61 6.85 0.35 3.64e-11 Body mass index; LUSC cis rs6424115 0.931 rs2982390 chr1:24147830 G/C cg10978503 chr1:24200527 CNR2 0.5 11.61 0.54 2.06e-26 Immature fraction of reticulocytes; LUSC cis rs2625529 0.824 rs2415121 chr15:72134018 C/T cg16672083 chr15:72433130 SENP8 -0.47 -7.8 -0.39 7.83e-14 Red blood cell count; LUSC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.5 -0.38 5.7e-13 Alzheimer's disease (late onset); LUSC cis rs3857536 0.813 rs6903411 chr6:66938288 T/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.82 0.39 7.05e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11608355 0.521 rs11066503 chr12:109842434 A/G cg19025524 chr12:109796872 NA -0.4 -7.37 -0.37 1.39e-12 Neuroticism; LUSC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg17366294 chr4:99064904 C4orf37 0.58 10.43 0.5 3.19e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg15369054 chr17:80825471 TBCD 0.54 6.91 0.35 2.42e-11 Bone mineral accretion in asthma (oral corticosteroid dose interaction); LUSC trans rs9393777 0.920 rs13191227 chr6:27390115 G/C cg06606381 chr12:133084897 FBRSL1 -1.02 -9.03 -0.44 1.37e-17 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05819172 chr1:33815750 PHC2 -0.4 -5.96 -0.31 6.41e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1712517 0.525 rs11191642 chr10:105055912 A/G cg04362960 chr10:104952993 NT5C2 -0.5 -6.75 -0.35 6.74e-11 Migraine; LUSC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg12463550 chr7:65579703 CRCP 0.42 5.94 0.31 7.2e-9 Aortic root size; LUSC cis rs4144743 1.000 rs2037150 chr17:45328718 G/A cg18085866 chr17:45331354 ITGB3 -0.75 -7.79 -0.39 8.26e-14 Body mass index; LUSC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg06221963 chr1:154839813 KCNN3 -0.6 -13.38 -0.59 5.65e-33 Prostate cancer; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg17937102 chr1:165667565 ALDH9A1 -0.37 -6.43 -0.33 4.49e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1784581 0.775 rs7755404 chr6:162427731 T/C cg17173639 chr6:162384350 PARK2 0.66 11.74 0.54 7.27e-27 Itch intensity from mosquito bite; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg04267008 chr7:1944627 MAD1L1 -0.54 -8.2 -0.41 5.35e-15 Bipolar disorder and schizophrenia; LUSC cis rs17001868 0.614 rs5995849 chr22:40777072 C/G cg07138101 chr22:40742427 ADSL -0.56 -7.09 -0.36 8.27e-12 Mammographic density (dense area); LUSC cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg09184832 chr6:79620586 NA -0.44 -7.18 -0.37 4.66e-12 Intelligence (multi-trait analysis); LUSC trans rs10096351 0.528 rs74588857 chr8:128336741 C/T cg10195415 chr17:73887371 TRIM65 0.4 6.37 0.33 6.34e-10 Breast cancer; LUSC cis rs11190604 0.945 rs2495735 chr10:102338609 G/A cg16342193 chr10:102329863 NA -0.36 -6.95 -0.36 1.87e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4888262 0.526 rs7191754 chr16:74610850 G/T cg01733217 chr16:74700730 RFWD3 0.75 12.17 0.55 1.88e-28 Testicular germ cell tumor; LUSC cis rs713587 0.563 rs10865315 chr2:25100738 C/A cg01884057 chr2:25150051 NA 0.44 10.11 0.48 3.94e-21 Body mass index in non-asthmatics; LUSC trans rs62103177 0.733 rs62103193 chr18:77629217 C/T cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg20295408 chr7:1910781 MAD1L1 -0.49 -7.05 -0.36 1.04e-11 Bipolar disorder and schizophrenia; LUSC cis rs17095355 1.000 rs9988702 chr10:111703389 G/A cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.7 -0.39 1.58e-13 Biliary atresia; LUSC cis rs2535633 0.631 rs11915851 chr3:53096047 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.39 0.37 1.21e-12 Body mass index; LUSC cis rs11148252 0.740 rs9536046 chr13:52955899 T/G cg00495681 chr13:53174319 NA 0.55 8.56 0.42 4.1e-16 Lewy body disease; LUSC cis rs2445762 0.659 rs55810637 chr15:51664903 G/A cg07517944 chr15:51633816 GLDN 0.37 6.25 0.32 1.27e-9 Hormone measurements; LUSC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg16060761 chr17:80687452 NA 0.39 5.83 0.3 1.33e-8 Breast cancer; LUSC trans rs11098499 0.863 rs11098532 chr4:120490726 C/A cg25214090 chr10:38739885 LOC399744 0.53 7.97 0.4 2.55e-14 Corneal astigmatism; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg12633890 chr1:116382096 NHLH2 0.35 5.99 0.31 5.49e-9 Schizophrenia; LUSC cis rs9359856 0.564 rs56224741 chr6:90475231 C/T cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.45 -0.42 9.19e-16 Bipolar disorder; LUSC cis rs854765 0.583 rs28428991 chr17:17827649 C/T cg09796270 chr17:17721594 SREBF1 0.43 7.6 0.38 2.97e-13 Total body bone mineral density; LUSC cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg03517284 chr6:25882590 NA -0.52 -9.74 -0.47 6.97e-20 Blood metabolite levels; LUSC cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg07817648 chr10:79422355 NA -0.55 -7.5 -0.38 5.96e-13 Bone mineral density; LUSC trans rs2197308 0.643 rs1842597 chr12:37862142 C/G cg06521331 chr12:34319734 NA 0.41 6.54 0.34 2.35e-10 Morning vs. evening chronotype; LUSC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg02117656 chr17:79614917 TSPAN10 -0.3 -5.67 -0.3 3.16e-8 Eye color traits; LUSC cis rs7647973 1.000 rs10155014 chr3:49432321 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.97 0.36 1.73e-11 Menarche (age at onset); LUSC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg23172400 chr8:95962367 TP53INP1 0.35 6.7 0.34 8.71e-11 Type 2 diabetes; LUSC cis rs6942756 0.806 rs2694572 chr7:128911721 A/G cg02491457 chr7:128862824 NA 0.48 7.27 0.37 2.64e-12 White matter hyperintensity burden; LUSC cis rs2180341 0.618 rs11154396 chr6:127638911 C/T cg24812749 chr6:127587940 RNF146 0.65 9.78 0.47 4.88e-20 Breast cancer; LUSC cis rs9399401 0.589 rs2294775 chr6:142766347 C/G cg04461802 chr6:142623433 GPR126 0.41 5.95 0.31 6.61e-9 Chronic obstructive pulmonary disease; LUSC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg01657329 chr11:68192670 LRP5 0.41 6.39 0.33 5.65e-10 Total body bone mineral density; LUSC cis rs8077889 0.645 rs1230393 chr17:41842592 A/G cg26893861 chr17:41843967 DUSP3 -1.13 -25.31 -0.81 1.16e-79 Triglycerides; LUSC cis rs240764 0.578 rs6927598 chr6:101232729 T/C cg09795085 chr6:101329169 ASCC3 0.44 6.27 0.32 1.13e-9 Neuroticism; LUSC cis rs9300255 0.537 rs1716182 chr12:123686127 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.15 -0.32 2.19e-9 Neutrophil percentage of white cells; LUSC cis rs865483 0.826 rs853198 chr17:35849342 A/C cg06716730 chr17:35851459 DUSP14 0.28 6.14 0.32 2.3e-9 Monocyte count; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg13397359 chr6:42928475 GNMT 0.65 10.85 0.51 1.04e-23 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs62432291 0.681 rs7757530 chr6:159647929 G/A cg14500486 chr6:159655392 FNDC1 0.52 5.84 0.3 1.22e-8 Joint mobility (Beighton score); LUSC trans rs7613875 0.620 rs17657688 chr3:50033228 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -7.58 -0.38 3.48e-13 Body mass index; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg21770322 chr7:97807741 LMTK2 0.43 7.38 0.37 1.26e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg18765753 chr7:1198926 ZFAND2A -0.41 -7.08 -0.36 8.6e-12 Longevity;Endometriosis; LUSC cis rs6669072 1.000 rs3856225 chr1:91242473 G/A cg08895590 chr1:91227319 NA -0.38 -8.61 -0.43 3.03e-16 Cognitive function; LUSC cis rs6494488 0.500 rs7165925 chr15:64985604 A/G cg08069370 chr15:64387884 SNX1 0.58 5.67 0.3 3.07e-8 Coronary artery disease; LUSC cis rs7267979 0.932 rs4280527 chr20:25544014 A/G cg03522245 chr20:25566470 NINL 0.37 6.0 0.31 5.2e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9653442 0.564 rs7593261 chr2:100789907 A/G cg07810366 chr2:100720526 AFF3 -0.41 -6.76 -0.35 6.22e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.25 -0.37 2.86e-12 Menarche (age at onset); LUSC trans rs4561177 0.548 rs61901857 chr11:109944838 G/T cg00999152 chr2:72369887 CYP26B1 -0.34 -5.98 -0.31 5.59e-9 Psoriasis vulgaris; LUSC cis rs3806843 0.766 rs6848 chr5:140086062 A/T cg26395211 chr5:140044315 WDR55 0.41 6.43 0.33 4.47e-10 Depressive symptoms (multi-trait analysis); LUSC cis rs11608355 0.515 rs7971160 chr12:109946751 T/A cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs11955175 0.850 rs111959286 chr5:40704141 A/T cg05478818 chr5:40835740 RPL37 0.74 5.89 0.31 9.43e-9 Bipolar disorder and schizophrenia; LUSC trans rs4698048 0.506 rs2080072 chr4:10235622 G/C cg26043149 chr18:55253948 FECH -0.53 -8.46 -0.42 8.44e-16 Skin aging (microtopography measurement); LUSC cis rs9323205 0.953 rs61144314 chr14:51620556 G/A cg23942311 chr14:51606299 NA -0.5 -10.26 -0.49 1.15e-21 Cancer; LUSC trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -13.76 -0.6 1.86e-34 Height; LUSC cis rs2455601 1.000 rs12418190 chr11:8899818 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.46 -0.33 3.77e-10 Schizophrenia; LUSC trans rs2953145 0.545 rs2975751 chr2:241521135 G/A cg12966876 chr2:111873850 ACOXL 0.33 6.4 0.33 5.25e-10 Bipolar disorder; LUSC cis rs12220238 1.000 rs12357530 chr10:75928654 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.88 0.35 2.97e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs11039100 0.607 rs34451835 chr11:5782456 C/G cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs2288327 0.545 rs2562834 chr2:179580583 T/C cg14011486 chr1:26737247 LIN28 0.5 6.17 0.32 1.96e-9 Atrial fibrillation; LUSC cis rs7267979 1.000 rs398036 chr20:25439850 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.11 0.74 1.73e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2295359 1.000 rs4655683 chr1:67611613 C/T cg17031739 chr1:67600172 NA 0.37 6.03 0.31 4.29e-9 Psoriasis; LUSC cis rs9818941 0.826 rs2670286 chr3:157638213 C/G cg08654915 chr3:157813417 NA 0.26 6.01 0.31 4.9e-9 Height; LUSC trans rs61931739 0.500 rs7313094 chr12:34457508 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.87e-34 Morning vs. evening chronotype; LUSC cis rs2348418 0.864 rs7977817 chr12:28715482 G/T cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs921968 0.591 rs3731877 chr2:219602499 G/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.09 -0.48 4.66e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs1535500 0.935 rs11753141 chr6:39283083 G/A cg06347083 chr6:39282316 KCNK17 -0.27 -5.97 -0.31 6.23e-9 Type 2 diabetes; LUSC cis rs6499755 0.965 rs9932163 chr16:55350683 C/A cg02859129 chr16:55357253 IRX6 0.35 5.85 0.3 1.18e-8 Hypospadias; LUSC cis rs12195417 0.719 rs1170330 chr6:83996875 T/A cg08257003 chr6:84140564 ME1 0.32 7.75 0.39 1.08e-13 Schizophrenia; LUSC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg23711669 chr6:146136114 FBXO30 -0.91 -18.2 -0.71 6.59e-52 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.863 rs3822195 chr4:120471660 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs8077889 0.672 rs15359 chr17:41843979 C/G cg26893861 chr17:41843967 DUSP3 -1.13 -26.27 -0.82 2.8e-83 Triglycerides; LUSC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg09359103 chr1:154839909 KCNN3 -0.7 -16.24 -0.66 4.09e-44 Prostate cancer; LUSC cis rs9467773 0.587 rs12214031 chr6:26376628 T/C cg09904177 chr6:26538194 HMGN4 -0.53 -8.23 -0.41 4.3e-15 Intelligence (multi-trait analysis); LUSC trans rs804280 0.542 rs34117651 chr8:11791617 G/C cg08975724 chr8:8085496 FLJ10661 0.48 6.94 0.36 2.09e-11 Myopia (pathological); LUSC trans rs11098499 0.909 rs1546502 chr4:120235898 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.23 0.32 1.38e-9 Corneal astigmatism; LUSC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg08219700 chr8:58056026 NA 0.69 8.22 0.41 4.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg05347473 chr6:146136440 FBXO30 0.6 10.6 0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs9463078 0.753 rs1980265 chr6:44928868 C/A cg25276700 chr6:44698697 NA -0.29 -5.9 -0.31 9.09e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg00431813 chr7:1051703 C7orf50 -0.47 -7.9 -0.4 4.06e-14 Longevity;Endometriosis; LUSC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg13206674 chr6:150067644 NUP43 0.43 6.48 0.33 3.36e-10 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.52 0.38 4.98e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs12579753 0.917 rs10778833 chr12:82197983 G/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs760794 0.764 rs7764632 chr6:19795585 C/G cg02404759 chr6:19790362 NA -0.41 -6.24 -0.32 1.36e-9 Endometriosis; LUSC cis rs7208859 0.524 rs77498725 chr17:29063986 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.86 -0.35 3.3e-11 Menopause (age at onset); LUSC trans rs7916697 0.520 rs12246624 chr10:70036562 C/T cg04882175 chr6:131122610 NA -0.56 -7.53 -0.38 4.79e-13 Optic disc area; LUSC cis rs4654899 0.929 rs7552999 chr1:21314454 T/C cg01072550 chr1:21505969 NA -0.56 -8.5 -0.42 6.28e-16 Superior frontal gyrus grey matter volume; LUSC cis rs4654899 0.802 rs17410008 chr1:21220701 G/C cg01072550 chr1:21505969 NA -0.51 -7.58 -0.38 3.37e-13 Superior frontal gyrus grey matter volume; LUSC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg20135002 chr11:47629003 NA -0.51 -7.91 -0.4 3.88e-14 Subjective well-being; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg20849893 chr7:64541193 NA 0.47 6.71 0.34 8.54e-11 Calcium levels; LUSC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1712517 0.771 rs7921655 chr10:105113701 C/T cg05636881 chr10:105038444 INA 0.41 6.75 0.35 6.73e-11 Migraine; LUSC cis rs955333 1.000 rs62434207 chr6:154950419 A/G cg20019720 chr6:154832845 CNKSR3 0.45 5.75 0.3 2.01e-8 Diabetic kidney disease; LUSC cis rs11971779 0.523 rs10279160 chr7:139090761 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg25427524 chr10:38739819 LOC399744 -0.71 -13.26 -0.59 1.53e-32 Extrinsic epigenetic age acceleration; LUSC cis rs10208940 0.920 rs12713643 chr2:68724129 C/G cg12452813 chr2:68675892 NA 0.58 5.95 0.31 6.61e-9 Urate levels in lean individuals; LUSC trans rs61931739 0.500 rs34997501 chr12:34549828 C/G cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.01e-11 Tonsillectomy; LUSC cis rs10464366 0.746 rs4723822 chr7:39141613 C/T cg10621924 chr7:39171070 POU6F2 0.42 6.26 0.32 1.21e-9 IgG glycosylation; LUSC trans rs629535 0.814 rs56326813 chr8:70107736 T/A cg21567404 chr3:27674614 NA -0.98 -15.88 -0.66 1.02e-42 Dupuytren's disease; LUSC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.27 0.45 2.39e-18 Monocyte percentage of white cells; LUSC cis rs116095464 1.000 rs3777237 chr5:307641 C/T cg22857025 chr5:266934 NA -1.14 -8.39 -0.42 1.39e-15 Breast cancer; LUSC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg18512352 chr11:47633146 NA 0.48 9.94 0.48 1.45e-20 Subjective well-being; LUSC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg03188948 chr7:1209495 NA 0.47 6.04 0.31 4.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg00579200 chr11:133705235 NA -0.41 -5.86 -0.31 1.1e-8 Childhood ear infection; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09239099 chr12:1100377 ERC1 -0.41 -6.35 -0.33 6.92e-10 Electrocardiographic conduction measures; LUSC cis rs10779751 1.000 rs11121698 chr1:11267283 C/T cg08854313 chr1:11322531 MTOR 0.91 16.32 0.67 1.93e-44 Body mass index; LUSC cis rs7216064 0.953 rs4790905 chr17:65863350 C/A cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg12463550 chr7:65579703 CRCP -0.49 -7.02 -0.36 1.24e-11 Aortic root size; LUSC cis rs9807841 0.670 rs10948 chr19:10754905 G/T cg17710535 chr19:10819994 QTRT1 0.43 6.93 0.35 2.14e-11 Inflammatory skin disease; LUSC cis rs6835098 0.924 rs12639929 chr4:174156538 C/T cg08422745 chr4:174089978 GALNT7 -0.79 -12.51 -0.56 1.08e-29 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs1670533 1.000 rs13107058 chr4:1054379 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.07 0.32 3.49e-9 Recombination rate (females); LUSC cis rs10416265 0.503 rs1981818 chr19:33615122 C/T cg03563238 chr19:33554763 RHPN2 0.34 5.84 0.3 1.24e-8 Bone properties (heel); LUSC cis rs3806843 0.966 rs3806844 chr5:140206263 A/T cg19875535 chr5:140030758 IK 0.49 7.92 0.4 3.52e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg22535103 chr8:58192502 C8orf71 -0.77 -8.59 -0.43 3.38e-16 Developmental language disorder (linguistic errors); LUSC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg09796270 chr17:17721594 SREBF1 -0.42 -7.39 -0.38 1.16e-12 Total body bone mineral density; LUSC cis rs6762 0.748 rs3059 chr11:840319 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.3 -0.41 2.65e-15 Mean platelet volume; LUSC trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.51 -7.09 -0.36 8.23e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01401337 chr9:96339159 PHF2 -0.4 -6.01 -0.31 4.74e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4917300 0.626 rs902821 chr8:143100074 G/A cg25363559 chr8:143086065 NA -0.32 -7.17 -0.37 4.72e-12 Amyotrophic lateral sclerosis; LUSC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg22782873 chr19:19639568 YJEFN3 -0.53 -6.45 -0.33 3.82e-10 Bipolar disorder; LUSC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.9 0.35 2.69e-11 Intelligence (multi-trait analysis); LUSC cis rs9399401 0.667 rs7757571 chr6:142702589 A/C cg04461802 chr6:142623433 GPR126 0.47 5.87 0.31 1.06e-8 Chronic obstructive pulmonary disease; LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.54 -0.42 4.79e-16 Gut microbiome composition (summer); LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg23034840 chr1:205782522 SLC41A1 0.62 8.8 0.43 7.43e-17 Menarche (age at onset); LUSC cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.56 0.38 3.9e-13 Colorectal cancer; LUSC trans rs61931739 0.534 rs7313137 chr12:34010231 T/G cg13010199 chr12:38710504 ALG10B 0.55 8.27 0.41 3.16e-15 Morning vs. evening chronotype; LUSC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg18240062 chr17:79603768 NPLOC4 0.69 12.96 0.58 2.22e-31 Eye color traits; LUSC trans rs11696501 0.688 rs2281211 chr20:44312858 C/T cg03272292 chr12:48577362 C12orf68 0.5 6.03 0.31 4.22e-9 Brain structure; LUSC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg24110177 chr3:50126178 RBM5 0.58 9.76 0.47 5.63e-20 Intelligence (multi-trait analysis); LUSC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg06558623 chr16:89946397 TCF25 1.01 10.69 0.51 3.78e-23 Skin colour saturation; LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg13126279 chr21:47581558 C21orf56 -0.47 -6.94 -0.36 1.99e-11 Testicular germ cell tumor; LUSC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.19 -0.32 1.79e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.05e-12 Mean platelet volume; LUSC cis rs11971779 0.680 rs6946393 chr7:139106169 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1348850 0.651 rs1901824 chr2:178225466 T/C cg22681709 chr2:178499509 PDE11A -0.34 -6.39 -0.33 5.45e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg13206674 chr6:150067644 NUP43 0.58 9.11 0.45 7.88e-18 Lung cancer; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg06600287 chr1:53387719 ECHDC2 0.31 6.22 0.32 1.46e-9 Monocyte count; LUSC cis rs2109514 0.902 rs6980387 chr7:116126882 A/G cg12739419 chr7:116140593 CAV2 -0.27 -5.77 -0.3 1.78e-8 Prevalent atrial fibrillation; LUSC cis rs17818399 0.547 rs4952833 chr2:46762034 T/C cg02822958 chr2:46747628 ATP6V1E2 0.44 6.46 0.33 3.74e-10 Height; LUSC cis rs2235649 0.753 rs7200472 chr16:1849669 T/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.1 -0.32 2.92e-9 Blood metabolite levels; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg00166722 chr3:10149974 C3orf24 0.55 7.58 0.38 3.39e-13 Alzheimer's disease; LUSC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.38 -5.79 -0.3 1.65e-8 Alzheimer's disease (late onset); LUSC cis rs7264396 0.635 rs6058363 chr20:34505054 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -8.28 -0.41 3.07e-15 Total cholesterol levels; LUSC cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg21535247 chr6:8435926 SLC35B3 0.56 8.56 0.42 4.21e-16 Motion sickness; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00841452 chr19:10535506 PDE4A 0.4 6.0 0.31 5.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg02527881 chr3:46936655 PTH1R 0.42 7.24 0.37 3.02e-12 Colorectal cancer; LUSC cis rs73195822 0.506 rs61440260 chr12:111142855 G/T cg12870014 chr12:110450643 ANKRD13A 0.67 7.4 0.38 1.13e-12 Itch intensity from mosquito bite; LUSC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg07424592 chr7:64974309 NA 0.65 5.74 0.3 2.15e-8 Diabetic kidney disease; LUSC trans rs9929218 1.000 rs12599517 chr16:68814590 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.44 -0.53 8.45e-26 Colorectal cancer; LUSC cis rs11039100 0.850 rs11039117 chr11:5832464 G/A cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2247341 1.000 rs8051 chr4:1694809 C/T cg07465881 chr4:1713556 SLBP 0.4 6.18 0.32 1.85e-9 Hip circumference adjusted for BMI;Height; LUSC cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.68 0.3 2.91e-8 Rheumatoid arthritis; LUSC trans rs12210905 0.925 rs11961181 chr6:26994163 C/G cg11837749 chr1:55047332 ACOT11 0.57 6.13 0.32 2.51e-9 Hip circumference adjusted for BMI; LUSC cis rs9790314 0.967 rs9821201 chr3:160996155 G/C cg04691961 chr3:161091175 C3orf57 -0.34 -5.78 -0.3 1.73e-8 Morning vs. evening chronotype; LUSC cis rs9527 0.590 rs12415388 chr10:104796345 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.6 0.47 1.95e-19 Arsenic metabolism; LUSC cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg14844989 chr11:31128820 NA -0.39 -6.02 -0.31 4.62e-9 Red blood cell count; LUSC cis rs4727027 0.870 rs11524138 chr7:148799125 G/A cg23158103 chr7:148848205 ZNF398 -0.47 -7.59 -0.38 3.21e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10781543 0.839 rs10870071 chr9:139382184 T/C cg14019695 chr9:139328340 INPP5E 0.51 9.75 0.47 6.07e-20 Monocyte percentage of white cells; LUSC cis rs7512552 0.809 rs696618 chr1:150376139 T/G cg15654264 chr1:150340011 RPRD2 0.63 10.38 0.49 4.66e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs354225 0.584 rs6749802 chr2:54824146 A/G cg01766943 chr2:54829624 SPTBN1 0.48 7.78 0.39 9.33e-14 Schizophrenia; LUSC cis rs3087591 0.919 rs2953004 chr17:29502723 C/T cg24425628 chr17:29625626 OMG;NF1 0.62 8.91 0.44 3.45e-17 Hip circumference; LUSC cis rs27434 0.529 rs34757 chr5:96152588 T/C cg16492584 chr5:96139282 ERAP1 -0.56 -7.71 -0.39 1.49e-13 Ankylosing spondylitis; LUSC cis rs2404602 0.692 rs34287706 chr15:76942402 A/C cg23625390 chr15:77176239 SCAPER 0.46 7.02 0.36 1.22e-11 Blood metabolite levels; LUSC cis rs3770081 1.000 rs111295372 chr2:86283357 T/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.99 -0.36 1.51e-11 Facial emotion recognition (sad faces); LUSC trans rs1864585 0.520 rs73208756 chr8:10657535 C/T cg26278703 chr11:58910052 FAM111A 0.53 5.98 0.31 5.84e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg21535247 chr6:8435926 SLC35B3 0.58 9.05 0.44 1.22e-17 Motion sickness; LUSC cis rs9467773 0.620 rs2504592 chr6:26640951 C/G cg09904177 chr6:26538194 HMGN4 0.66 11.72 0.54 8.26e-27 Intelligence (multi-trait analysis); LUSC trans rs6582630 0.513 rs11181246 chr12:38302670 C/T cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs2406342 0.920 rs4890784 chr18:74484655 C/T cg16472389 chr18:74514291 NA 0.37 5.78 0.3 1.75e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg05666077 chr12:56652063 ANKRD52 0.35 5.97 0.31 6.23e-9 Educational attainment (years of education); LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg21672276 chr3:44754072 ZNF502 -0.41 -6.68 -0.34 1.03e-10 Depressive symptoms; LUSC cis rs2625529 0.627 rs1037680 chr15:72514319 T/C cg16672083 chr15:72433130 SENP8 -0.49 -7.25 -0.37 2.97e-12 Red blood cell count; LUSC cis rs8099014 0.834 rs4940699 chr18:56109007 A/C cg12907477 chr18:56117327 MIR122 0.44 7.02 0.36 1.28e-11 Platelet count; LUSC cis rs5769707 0.681 rs1107514 chr22:50042383 T/C cg05373962 chr22:49881684 NA -0.4 -8.29 -0.41 2.85e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2299587 0.560 rs3913555 chr8:17781810 A/C cg01800426 chr8:17659068 MTUS1 -0.49 -6.45 -0.33 3.86e-10 Economic and political preferences; LUSC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.95 0.31 6.91e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7582720 1.000 rs72932574 chr2:203866336 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 8.37 0.42 1.63e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6541297 1.000 rs6665260 chr1:230279067 G/T cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.22e-15 Coronary artery disease; LUSC cis rs10782582 0.593 rs12132750 chr1:76136222 A/G cg10523679 chr1:76189770 ACADM -0.49 -7.25 -0.37 2.96e-12 Daytime sleep phenotypes; LUSC cis rs2731664 0.792 rs465670 chr5:176877624 C/T cg23176889 chr5:176863531 GRK6 -0.68 -14.07 -0.61 1.21e-35 Intelligence (multi-trait analysis); LUSC cis rs4285028 0.948 rs1920290 chr3:121672305 A/G cg11130432 chr3:121712080 ILDR1 -0.63 -9.49 -0.46 4.55e-19 Multiple sclerosis; LUSC cis rs929596 0.755 rs3771341 chr2:234673239 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.69 -11.59 -0.54 2.41e-26 Total bilirubin levels in HIV-1 infection; LUSC cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.68 0.47 1.06e-19 Bipolar disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11539424 chr4:141348862 CLGN -0.41 -5.96 -0.31 6.26e-9 Electrocardiographic conduction measures; LUSC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg19729930 chr2:74357872 NA 0.86 14.94 0.63 5.33e-39 Gestational age at birth (maternal effect); LUSC cis rs9479482 0.935 rs563278 chr6:150364427 G/C cg00432049 chr6:150390894 ULBP3 -0.28 -6.0 -0.31 5.05e-9 Alopecia areata; LUSC cis rs11997175 0.902 rs7462610 chr8:33693318 A/T ch.8.33884649F chr8:33765107 NA 0.42 6.53 0.34 2.51e-10 Body mass index; LUSC cis rs9311676 0.594 rs55954186 chr3:58436476 G/A cg13750441 chr3:58318267 PXK 0.36 6.93 0.35 2.21e-11 Systemic lupus erythematosus; LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC trans rs2797160 1.000 rs4897152 chr6:126002400 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.74 -0.35 6.9e-11 Endometrial cancer; LUSC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg03433033 chr1:76189801 ACADM 0.81 12.65 0.57 3.11e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs80282103 0.867 rs11819178 chr10:1098417 A/G cg23359895 chr10:1095482 IDI1 0.68 6.26 0.32 1.16e-9 Glomerular filtration rate (creatinine); LUSC cis rs11792861 0.926 rs7046725 chr9:111882729 T/G cg13535736 chr9:111863775 C9orf5 -0.39 -6.58 -0.34 1.87e-10 Menarche (age at onset); LUSC cis rs5758659 0.652 rs133327 chr22:42407689 T/C cg15557168 chr22:42548783 NA -0.33 -5.72 -0.3 2.43e-8 Cognitive function; LUSC cis rs9788721 0.902 rs17486195 chr15:78865197 A/G cg06917634 chr15:78832804 PSMA4 -0.44 -5.97 -0.31 5.94e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg06022373 chr22:39101656 GTPBP1 0.89 14.71 0.63 4.17e-38 Menopause (age at onset); LUSC cis rs7786808 0.615 rs1563066 chr7:158194935 A/C cg01191920 chr7:158217561 PTPRN2 -0.52 -10.81 -0.51 1.5e-23 Obesity-related traits; LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg06600287 chr1:53387719 ECHDC2 -0.3 -6.37 -0.33 6.19e-10 Monocyte count; LUSC cis rs10752881 1.000 rs6697739 chr1:182983333 A/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.53 0.5 1.37e-22 Colorectal cancer; LUSC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg06238570 chr21:40685208 BRWD1 -0.62 -10.51 -0.5 1.66e-22 Cognitive function; LUSC cis rs17253792 0.822 rs75560658 chr14:56079896 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs2282300 0.956 rs654710 chr11:30394303 A/G cg25418670 chr11:30344373 C11orf46 0.49 6.81 0.35 4.67e-11 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07866464 chr2:106810675 UXS1 -0.44 -6.74 -0.35 6.97e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7582180 0.629 rs4850926 chr2:100954117 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.65 -0.43 2.25e-16 Intelligence (multi-trait analysis); LUSC cis rs61931739 1.000 rs12305700 chr12:34036332 T/C cg06521331 chr12:34319734 NA 0.4 6.62 0.34 1.44e-10 Morning vs. evening chronotype; LUSC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg13683864 chr3:40499215 RPL14 -1.15 -21.55 -0.76 3.67e-65 Renal cell carcinoma; LUSC cis rs7246967 0.673 rs8104564 chr19:22867207 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.77 0.43 9.36e-17 Alzheimer's disease; LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg25072359 chr17:41440525 NA 0.64 9.02 0.44 1.51e-17 Menopause (age at onset); LUSC cis rs950881 0.932 rs10173081 chr2:102957348 C/T cg20060108 chr2:102954350 IL1RL1 0.46 6.01 0.31 4.77e-9 Allergy; LUSC cis rs727505 0.564 rs57841320 chr7:124847732 T/A cg23710748 chr7:124431027 NA -0.4 -6.85 -0.35 3.6e-11 Lewy body disease; LUSC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.69e-14 Systolic blood pressure; LUSC cis rs477692 1.000 rs577227 chr10:131404528 C/T cg26102564 chr10:131424627 MGMT 0.44 6.81 0.35 4.51e-11 Response to temozolomide; LUSC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg18230493 chr5:56204884 C5orf35 -0.88 -13.39 -0.59 4.99e-33 Initial pursuit acceleration; LUSC cis rs67311347 0.544 rs6769627 chr3:40327845 G/A cg12215294 chr3:40350768 EIF1B -0.34 -5.75 -0.3 2.04e-8 Renal cell carcinoma; LUSC cis rs1957429 0.520 rs72625648 chr14:65344602 A/G cg23373153 chr14:65346875 NA -0.89 -8.08 -0.4 1.24e-14 Pediatric areal bone mineral density (radius); LUSC trans rs6502050 0.835 rs7213172 chr17:80085703 G/T cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs66887589 0.592 rs28580295 chr4:120278873 C/T cg24375607 chr4:120327624 NA 0.53 8.07 0.4 1.31e-14 Diastolic blood pressure; LUSC cis rs4363385 0.776 rs1890284 chr1:152942190 G/A cg00922841 chr1:152955080 SPRR1A -0.45 -7.27 -0.37 2.62e-12 Inflammatory skin disease; LUSC cis rs1712517 0.566 rs1163073 chr10:105022934 C/T cg04362960 chr10:104952993 NT5C2 0.48 6.32 0.33 8.47e-10 Migraine; LUSC trans rs8073060 0.586 rs226089 chr17:34016935 C/T cg19694781 chr19:47549865 TMEM160 -1.13 -17.91 -0.7 9.52e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1595825 1.000 rs1304164 chr2:198877234 C/A cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs427941 0.655 rs201468 chr7:101742673 C/T cg06246474 chr7:101738831 CUX1 0.38 6.23 0.32 1.4e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs73129298 0.551 rs6020175 chr20:48602116 T/C cg25655593 chr20:48599521 SNAI1 0.59 6.36 0.33 6.69e-10 Inflammatory skin disease; LUSC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg18876405 chr7:65276391 NA -0.56 -8.91 -0.44 3.45e-17 Aortic root size; LUSC cis rs7945705 0.791 rs12421789 chr11:8813956 G/A cg12365402 chr11:9010492 NRIP3 -0.45 -8.17 -0.41 6.4e-15 Hemoglobin concentration; LUSC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs412000 0.507 rs2680688 chr17:56450524 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -6.49 -0.33 3.1e-10 Primary tooth development (time to first tooth eruption); LUSC cis rs10761482 0.861 rs10821733 chr10:62103405 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs1559088 0.847 rs7254758 chr19:33608047 T/A cg17764715 chr19:33622953 WDR88 0.6 8.23 0.41 4.37e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg24250549 chr1:154909240 PMVK -0.66 -11.12 -0.52 1.16e-24 Prostate cancer; LUSC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg24675658 chr1:53192096 ZYG11B 0.77 13.17 0.58 3.54e-32 Monocyte count; LUSC cis rs9653442 0.564 rs6707067 chr2:100767232 G/A cg07810366 chr2:100720526 AFF3 -0.43 -7.31 -0.37 2.03e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs11118883 0.567 rs11579212 chr1:222072819 A/C cg10861897 chr8:49835988 NA 0.24 6.05 0.31 3.98e-9 Colorectal cancer; LUSC cis rs6700896 0.500 rs12040007 chr1:66080160 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg13047869 chr3:10149882 C3orf24 0.56 7.88 0.4 4.57e-14 Alzheimer's disease; LUSC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg11663144 chr21:46675770 NA -0.41 -7.22 -0.37 3.46e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg13175981 chr1:150552382 MCL1 0.47 6.7 0.34 8.66e-11 Tonsillectomy; LUSC cis rs61869271 0.799 rs35501899 chr10:116739109 T/G cg23260525 chr10:116636907 FAM160B1 0.29 5.71 0.3 2.43e-8 Tonsillectomy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24068859 chr3:194392930 LSG1 -0.43 -6.44 -0.33 4.17e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg03709012 chr19:19516395 GATAD2A 0.74 11.27 0.52 3.6e-25 Tonsillectomy; LUSC cis rs7677751 0.806 rs67432867 chr4:55104454 A/T cg17187183 chr4:55093834 PDGFRA 0.4 6.11 0.32 2.83e-9 Corneal astigmatism; LUSC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg06238570 chr21:40685208 BRWD1 0.49 7.45 0.38 8.26e-13 Cognitive function; LUSC cis rs7674212 0.581 rs13150953 chr4:103942498 A/G cg16532752 chr4:104119610 CENPE -0.43 -5.87 -0.31 1.04e-8 Type 2 diabetes; LUSC cis rs977987 0.843 rs6564260 chr16:75447426 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.62 -0.34 1.4e-10 Dupuytren's disease; LUSC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg06481639 chr22:41940642 POLR3H -0.5 -5.78 -0.3 1.68e-8 Vitiligo; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01338834 chr21:40720919 HMGN1 0.47 7.4 0.38 1.11e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg14895029 chr7:2775587 GNA12 -0.39 -6.03 -0.31 4.45e-9 Height; LUSC cis rs6504663 0.558 rs11871603 chr17:48559037 T/G cg22571038 chr17:48585470 MYCBPAP 0.49 6.26 0.32 1.19e-9 Visceral fat; LUSC trans rs9860340 0.730 rs73137449 chr3:87641049 C/G cg03644585 chr7:884825 UNC84A 0.42 6.06 0.31 3.62e-9 Electroencephalographic traits in alcoholism; LUSC cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg06271696 chr7:157225062 NA -0.42 -8.21 -0.41 4.79e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg20476274 chr7:133979776 SLC35B4 0.78 12.95 0.58 2.41e-31 Mean platelet volume; LUSC cis rs394563 0.517 rs385303 chr6:149779064 C/T cg03678062 chr6:149772716 ZC3H12D -0.35 -6.44 -0.33 4.15e-10 Dupuytren's disease; LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.5 -6.45 -0.33 3.86e-10 Renal function-related traits (BUN); LUSC cis rs9807989 0.507 rs6734762 chr2:103062926 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.14 0.36 6.05e-12 Asthma; LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.08 0.52 1.69e-24 Prudent dietary pattern; LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg22920501 chr2:26401640 FAM59B -0.82 -12.46 -0.56 1.59e-29 Gut microbiome composition (summer); LUSC cis rs4363385 0.530 rs61815714 chr1:152921380 C/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.21 -0.32 1.58e-9 Inflammatory skin disease; LUSC cis rs1322512 0.713 rs2758794 chr6:152930965 T/C cg27316956 chr6:152958899 SYNE1 -0.35 -5.85 -0.31 1.15e-8 Tonometry; LUSC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs1559088 0.576 rs11084707 chr19:33612873 C/T cg17764715 chr19:33622953 WDR88 0.58 8.4 0.42 1.3e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg10802521 chr3:52805072 NEK4 -0.44 -6.84 -0.35 3.83e-11 Electroencephalogram traits; LUSC cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg05347473 chr6:146136440 FBXO30 0.53 9.01 0.44 1.67e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg17330251 chr7:94953956 PON1 -0.38 -5.88 -0.31 9.77e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7833986 0.534 rs2667980 chr8:56896541 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.69 11.11 0.52 1.24e-24 Height; LUSC trans rs61931739 0.517 rs12816252 chr12:34067693 G/A cg13010199 chr12:38710504 ALG10B 0.57 8.61 0.43 2.89e-16 Morning vs. evening chronotype; LUSC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg06238570 chr21:40685208 BRWD1 -0.56 -9.03 -0.44 1.37e-17 Menarche (age at onset); LUSC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg03289416 chr15:75166202 SCAMP2 0.45 6.75 0.35 6.49e-11 Breast cancer; LUSC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg22823121 chr1:150693482 HORMAD1 0.5 7.7 0.39 1.52e-13 Melanoma; LUSC cis rs76878669 0.561 rs4930177 chr11:66120784 T/C cg18002602 chr11:66138449 SLC29A2 0.45 8.12 0.41 8.95e-15 Educational attainment (years of education); LUSC cis rs2797160 0.935 rs1739379 chr6:126012593 T/C cg05901451 chr6:126070800 HEY2 0.57 8.66 0.43 2.04e-16 Endometrial cancer; LUSC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg10664184 chr19:17420304 DDA1 0.47 6.13 0.32 2.46e-9 Systemic lupus erythematosus; LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.31 0.53 2.45e-25 Menopause (age at onset); LUSC cis rs9403521 1.000 rs7766510 chr6:144002291 C/G cg18240653 chr6:144019428 PHACTR2 -0.48 -5.93 -0.31 7.7e-9 Obesity-related traits; LUSC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg19230755 chr7:65878503 NA -0.4 -5.73 -0.3 2.18e-8 Aortic root size; LUSC cis rs3857536 0.740 rs7763555 chr6:66889930 C/T cg07460842 chr6:66804631 NA -0.47 -6.54 -0.34 2.29e-10 Blood trace element (Cu levels); LUSC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg16624210 chr5:671434 TPPP 0.49 6.12 0.32 2.58e-9 Lung disease severity in cystic fibrosis; LUSC cis rs11190604 1.000 rs11190589 chr10:102275471 A/G cg07080220 chr10:102295463 HIF1AN 0.68 9.4 0.46 9.2e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1801251 0.778 rs2675967 chr2:233736133 C/G cg25237894 chr2:233734115 C2orf82 -0.33 -6.05 -0.31 3.97e-9 Coronary artery disease; LUSC cis rs1577917 0.771 rs6454486 chr6:86433587 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.49 7.71 0.39 1.46e-13 Response to antipsychotic treatment; LUSC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg15744005 chr10:104629667 AS3MT -0.28 -5.93 -0.31 7.59e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg11845111 chr2:191398756 TMEM194B 0.54 9.3 0.45 1.83e-18 Pulse pressure; LUSC cis rs12365397 0.526 rs11607331 chr11:43157244 T/C cg03447554 chr11:43094025 NA 0.35 5.89 0.31 9.33e-9 Migraine; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15941057 chr17:27169869 C17orf63 -0.42 -6.33 -0.33 8.1e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg01238044 chr22:24384105 GSTT1 -0.5 -7.24 -0.37 3.03e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg09085632 chr11:111637200 PPP2R1B -1.06 -17.57 -0.69 2.14e-49 Primary sclerosing cholangitis; LUSC cis rs62400317 0.762 rs10484625 chr6:44823449 G/A cg18551225 chr6:44695536 NA -0.46 -7.41 -0.38 1.02e-12 Total body bone mineral density; LUSC cis rs7100689 0.646 rs10788562 chr10:82072310 C/T cg01528321 chr10:82214614 TSPAN14 -0.83 -12.83 -0.57 6.65e-31 Post bronchodilator FEV1; LUSC cis rs9815354 0.812 rs73081392 chr3:41923009 G/A cg03022575 chr3:42003672 ULK4 0.83 8.57 0.42 3.85e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9329221 0.507 rs12678938 chr8:10016969 C/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.51 -0.34 2.8e-10 Neuroticism; LUSC cis rs16912285 0.688 rs7124856 chr11:24324926 C/T ch.11.24196551F chr11:24239977 NA 0.9 9.61 0.47 1.81e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9393777 0.623 rs9348719 chr6:26470032 T/C cg12292205 chr6:26970375 C6orf41 -0.63 -7.51 -0.38 5.42e-13 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19429466 chr4:87515395 PTPN13 -0.38 -6.14 -0.32 2.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs61931739 0.500 rs7311302 chr12:34557211 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg05347473 chr6:146136440 FBXO30 0.56 9.49 0.46 4.47e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg03709012 chr19:19516395 GATAD2A 0.83 14.07 0.61 1.24e-35 Tonsillectomy; LUSC cis rs28829049 0.597 rs34219832 chr1:19502432 C/T cg13387374 chr1:19411106 UBR4 0.44 6.23 0.32 1.39e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg05234568 chr11:5960015 NA -0.65 -9.51 -0.46 3.76e-19 DNA methylation (variation); LUSC cis rs9790314 0.690 rs1599390 chr3:160833246 A/G cg03342759 chr3:160939853 NMD3 -0.41 -6.76 -0.35 6.14e-11 Morning vs. evening chronotype; LUSC cis rs35146811 0.700 rs866500 chr7:99840461 A/G cg13334819 chr7:99746414 C7orf59 0.49 6.09 0.32 3.07e-9 Coronary artery disease; LUSC cis rs11992162 0.613 rs6998690 chr8:11798796 A/T cg21775007 chr8:11205619 TDH 0.44 5.96 0.31 6.52e-9 Monocyte count; LUSC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg08470875 chr2:26401718 FAM59B 0.69 8.8 0.43 7.27e-17 Gut microbiome composition (summer); LUSC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.09 14.43 0.62 5.1e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg06784218 chr1:46089804 CCDC17 -0.47 -8.97 -0.44 2.13e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs478304 0.651 rs11604462 chr11:65551648 G/A cg17480646 chr11:65405466 SIPA1 -0.45 -5.83 -0.3 1.31e-8 Acne (severe); LUSC cis rs7903847 0.642 rs7088410 chr10:99135539 G/T cg20016023 chr10:99160130 RRP12 -0.34 -8.38 -0.42 1.45e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg12927641 chr6:109611667 NA -0.37 -6.38 -0.33 5.82e-10 Reticulocyte fraction of red cells; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg05064044 chr6:292385 DUSP22 -0.72 -11.82 -0.54 3.69e-27 Menopause (age at onset); LUSC cis rs7640424 0.628 rs7628325 chr3:107816314 G/A cg09227934 chr3:107805635 CD47 -0.55 -7.91 -0.4 3.84e-14 Body mass index; LUSC cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Alcohol dependence; LUSC cis rs965513 1.000 rs10739496 chr9:100552559 C/T cg13688889 chr9:100608707 NA -0.51 -7.75 -0.39 1.13e-13 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.48 0.46 5e-19 Mean platelet volume; LUSC trans rs7944735 0.517 rs7952205 chr11:48199227 A/G cg03929089 chr4:120376271 NA 0.68 6.39 0.33 5.54e-10 Intraocular pressure; LUSC cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg16339924 chr4:17578868 LAP3 0.59 9.17 0.45 4.96e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03821727 chr12:1026369 RAD52 -0.4 -5.97 -0.31 5.93e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg22166914 chr1:53195759 ZYG11B -0.54 -8.68 -0.43 1.73e-16 Monocyte count; LUSC cis rs11025559 0.812 rs16906280 chr11:20472242 T/C cg19653624 chr11:20408972 PRMT3 -0.69 -8.84 -0.44 5.41e-17 Pursuit maintenance gain; LUSC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg02423579 chr7:2872169 GNA12 -0.43 -6.25 -0.32 1.28e-9 Height; LUSC cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.14e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6977660 1.000 rs12531373 chr7:19816825 A/C cg07541023 chr7:19748670 TWISTNB 0.52 6.01 0.31 4.83e-9 Thyroid stimulating hormone; LUSC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg00825309 chr19:58991885 ZNF446 -0.5 -7.23 -0.37 3.35e-12 Uric acid clearance; LUSC cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg15556689 chr8:8085844 FLJ10661 -0.6 -9.3 -0.45 1.93e-18 Systolic blood pressure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18247339 chr14:35183597 CFL2 0.4 6.33 0.33 8e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1814175 0.645 rs28634872 chr11:50042175 T/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs2370759 0.891 rs76164690 chr10:32590362 T/G cg01819863 chr10:32635814 EPC1 1.06 10.97 0.51 4.02e-24 Sexual dysfunction (female); LUSC trans rs7786877 0.626 rs11983745 chr7:100223678 T/C cg06565620 chr18:47792949 CCDC11 0.53 5.97 0.31 6.1e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.15 -0.45 5.74e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs67072384 1.000 rs11235579 chr11:72453095 A/G cg04827223 chr11:72435913 ARAP1 -0.8 -7.39 -0.37 1.18e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs1997103 1.000 rs1997102 chr7:55399322 A/C cg20935933 chr6:143382018 AIG1 -0.51 -7.31 -0.37 1.98e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26159030 chr19:36214806 MLL4 0.42 6.43 0.33 4.35e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg12463550 chr7:65579703 CRCP 0.45 6.76 0.35 6.19e-11 Aortic root size; LUSC cis rs12367572 0.663 rs1118481 chr12:45354469 C/G cg04608330 chr12:45269318 NELL2 -0.38 -5.75 -0.3 2.06e-8 Gut microbiome composition (summer); LUSC cis rs2486288 0.586 rs12909625 chr15:45572053 C/A cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.77 -0.39 9.67e-14 Glomerular filtration rate; LUSC cis rs62400317 0.762 rs62436375 chr6:44875818 T/C cg18551225 chr6:44695536 NA -0.46 -7.44 -0.38 8.7e-13 Total body bone mineral density; LUSC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg24881330 chr22:46731750 TRMU 0.89 8.95 0.44 2.52e-17 LDL cholesterol;Cholesterol, total; LUSC trans rs877282 0.945 rs11253391 chr10:788752 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs6906287 0.647 rs7772214 chr6:118793703 A/T cg21191810 chr6:118973309 C6orf204 0.32 5.84 0.3 1.21e-8 Electrocardiographic conduction measures; LUSC cis rs7084921 0.578 rs11190393 chr10:101869988 C/T cg02250046 chr10:101825185 CPN1 -0.33 -6.02 -0.31 4.5e-9 Bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10839663 chr1:113261613 NA -0.42 -6.35 -0.33 7.08e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9747201 0.926 rs34153075 chr17:80135728 C/A cg17462356 chr17:80056334 FASN 0.43 5.87 0.31 1.03e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs7824557 0.527 rs2409756 chr8:11242025 A/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.16 -0.32 2.09e-9 Retinal vascular caliber; LUSC cis rs9814567 0.896 rs7642266 chr3:134346025 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.97 -0.61 2.98e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4474465 0.850 rs10793326 chr11:78255422 A/C cg27205649 chr11:78285834 NARS2 0.55 6.45 0.33 3.87e-10 Alzheimer's disease (survival time); LUSC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg04733989 chr22:42467013 NAGA 0.55 8.67 0.43 1.95e-16 Schizophrenia; LUSC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg18876405 chr7:65276391 NA 0.55 8.59 0.43 3.48e-16 Aortic root size; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg16371341 chr5:56469761 GPBP1 0.75 6.23 0.32 1.43e-9 Body mass index; LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.07 0.52 1.76e-24 Alzheimer's disease; LUSC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg04287289 chr16:89883240 FANCA 0.82 14.05 0.61 1.48e-35 Vitiligo; LUSC cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.51 -0.42 5.93e-16 Chronic sinus infection; LUSC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg02018176 chr4:1364513 KIAA1530 0.45 7.38 0.37 1.25e-12 Obesity-related traits; LUSC cis rs12760731 0.565 rs12036491 chr1:178163651 C/A cg00404053 chr1:178313656 RASAL2 0.66 6.82 0.35 4.26e-11 Obesity-related traits; LUSC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg04317338 chr11:64019027 PLCB3 0.63 6.98 0.36 1.57e-11 Mean platelet volume; LUSC cis rs10789491 1.000 rs1371834 chr1:47176894 G/A cg15501359 chr1:47185051 KIAA0494 0.81 11.42 0.53 1.05e-25 Response to hepatitis C treatment; LUSC cis rs2120019 1.000 rs35736167 chr15:75332002 T/G cg09165964 chr15:75287851 SCAMP5 -1.15 -18.88 -0.72 1.33e-54 Blood trace element (Zn levels); LUSC cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.74 0.3 2.18e-8 Rheumatoid arthritis; LUSC cis rs4595586 0.545 rs2388175 chr12:39389217 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.32e-9 Morning vs. evening chronotype; LUSC trans rs2832191 0.740 rs2012645 chr21:30445961 G/A cg14791747 chr16:20752902 THUMPD1 -0.4 -6.14 -0.32 2.33e-9 Dental caries; LUSC cis rs2625529 0.668 rs34189331 chr15:72404573 A/T cg16672083 chr15:72433130 SENP8 -0.51 -7.89 -0.4 4.44e-14 Red blood cell count; LUSC cis rs7503807 1.000 rs4889775 chr17:78592287 A/G cg09596252 chr17:78655493 RPTOR 0.42 7.39 0.37 1.19e-12 Obesity; LUSC trans rs11681884 0.892 rs17042888 chr2:113862173 C/T cg02642549 chr5:77805886 LHFPL2 -0.58 -5.99 -0.31 5.52e-9 Stroke; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05896465 chr22:45560692 NUP50 0.47 6.77 0.35 5.92e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg24578937 chr1:2090814 PRKCZ 0.47 10.53 0.5 1.43e-22 Height; LUSC trans rs2797160 1.000 rs1739348 chr6:126014573 T/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.88 0.35 2.9e-11 Endometrial cancer; LUSC cis rs6500395 0.962 rs1477135 chr16:48726823 C/T cg04672837 chr16:48644449 N4BP1 0.46 6.67 0.34 1.06e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs950027 0.549 rs11070452 chr15:45594836 C/A cg26924012 chr15:45694286 SPATA5L1 -0.76 -11.13 -0.52 1.1e-24 Response to fenofibrate (adiponectin levels); LUSC cis rs12618769 0.625 rs3769709 chr2:99187433 A/T cg10123293 chr2:99228465 UNC50 0.46 7.43 0.38 9.29e-13 Bipolar disorder; LUSC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.44e-10 Menopause (age at onset); LUSC trans rs1814175 0.715 rs7479622 chr11:49673340 T/G cg03929089 chr4:120376271 NA -0.99 -18.0 -0.7 4.19e-51 Height; LUSC trans rs7647973 0.592 rs6774202 chr3:49687779 T/G cg21659725 chr3:3221576 CRBN -0.69 -8.04 -0.4 1.58e-14 Menarche (age at onset); LUSC cis rs11690935 0.632 rs6723259 chr2:172622527 A/C cg13550731 chr2:172543902 DYNC1I2 0.58 9.13 0.45 6.47e-18 Schizophrenia; LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg08948841 chr4:1244042 CTBP1;C4orf42 0.31 6.0 0.31 5.02e-9 Obesity-related traits; LUSC cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg07148914 chr20:33460835 GGT7 0.57 8.66 0.43 1.99e-16 Height; LUSC cis rs13256369 0.755 rs11776987 chr8:8559401 C/G cg00074818 chr8:8560427 CLDN23 0.58 9.42 0.46 7.61e-19 Obesity-related traits; LUSC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.63e-9 Aortic root size; LUSC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg27129171 chr3:47204927 SETD2 0.74 13.09 0.58 6.95e-32 Colorectal cancer; LUSC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg19454999 chr17:41278357 BRCA1;NBR2 -0.52 -9.21 -0.45 3.68e-18 Menopause (age at onset); LUSC cis rs908922 0.676 rs1970283 chr1:152495619 G/C cg20991723 chr1:152506922 NA 0.49 9.13 0.45 6.46e-18 Hair morphology; LUSC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.83 12.39 0.56 2.88e-29 Cognitive test performance; LUSC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg22535103 chr8:58192502 C8orf71 -0.74 -9.37 -0.46 1.15e-18 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg17724175 chr1:150552817 MCL1 -0.35 -6.3 -0.33 9.36e-10 Tonsillectomy; LUSC cis rs654351 0.541 rs533746 chr6:10388968 C/T cg17959970 chr6:10383164 NA 0.36 6.68 0.34 1.01e-10 Squamous cell lung carcinoma; LUSC cis rs3020736 0.500 rs9620026 chr22:42498578 C/T cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs62103177 0.608 rs59300126 chr18:77694439 C/A cg14227996 chr4:17616232 MED28 0.67 7.1 0.36 7.65e-12 Opioid sensitivity; LUSC cis rs344364 0.552 rs388928 chr16:1909657 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.41 5.94 0.31 7.34e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9549367 0.713 rs9549682 chr13:113830181 C/T cg18105134 chr13:113819100 PROZ -0.77 -10.74 -0.51 2.62e-23 Platelet distribution width; LUSC cis rs28735056 0.935 rs537962 chr18:77592660 C/G cg20368463 chr18:77673604 PQLC1 0.54 7.82 0.39 7.17e-14 Schizophrenia; LUSC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg04414720 chr1:150670196 GOLPH3L -0.4 -6.18 -0.32 1.88e-9 Tonsillectomy; LUSC cis rs5770917 1.000 rs2073605 chr22:51008850 A/G cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.64 -5.82 -0.3 1.36e-8 Narcolepsy; LUSC cis rs62432291 0.681 rs404435 chr6:159654487 G/T cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC cis rs9527 0.590 rs7092029 chr10:104823909 A/T cg05855489 chr10:104503620 C10orf26 0.53 8.01 0.4 1.98e-14 Arsenic metabolism; LUSC cis rs17030434 1.000 rs12646124 chr4:154718084 G/T cg14289246 chr4:154710475 SFRP2 -0.53 -6.92 -0.35 2.32e-11 Electrocardiographic conduction measures; LUSC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.86 -0.44 4.75e-17 Gut microbiome composition (summer); LUSC cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg23711669 chr6:146136114 FBXO30 -0.82 -14.68 -0.63 5.24e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs4243830 0.850 rs12744992 chr1:6601290 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -10.4 -0.49 3.84e-22 Body mass index; LUSC cis rs68170813 0.605 rs4730227 chr7:106904031 G/C cg02696742 chr7:106810147 HBP1 -0.65 -9.96 -0.48 1.2e-20 Coronary artery disease; LUSC cis rs1958560 0.867 rs2185454 chr14:65870594 G/T cg03016385 chr14:66212404 NA -0.39 -6.03 -0.31 4.32e-9 Menarche (age at onset); LUSC cis rs600231 0.706 rs3782091 chr11:65336483 G/T cg17120908 chr11:65337727 SSSCA1 0.58 9.57 0.46 2.44e-19 Bone mineral density; LUSC cis rs3806843 0.576 rs246063 chr5:140324492 T/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs12134245 0.874 rs17501937 chr1:92021705 C/T cg25838465 chr1:92012736 NA 0.56 10.21 0.49 1.77e-21 Breast cancer; LUSC cis rs34375054 0.641 rs34624329 chr12:125608028 T/G cg06287003 chr12:125626642 AACS -0.38 -6.67 -0.34 1.04e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg01283332 chr5:1856932 NA -0.34 -6.49 -0.33 3.03e-10 Cardiovascular disease risk factors; LUSC cis rs4930103 0.591 rs11042048 chr11:1986240 C/G cg26856596 chr11:1961893 NA 0.34 6.3 0.33 9.45e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs997295 0.618 rs3784698 chr15:68007582 G/C cg08079166 chr15:68083412 MAP2K5 -0.36 -6.34 -0.33 7.28e-10 Motion sickness; LUSC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg25258033 chr6:167368657 RNASET2 -0.46 -7.82 -0.39 7.17e-14 Crohn's disease; LUSC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg13206674 chr6:150067644 NUP43 0.59 9.25 0.45 2.68e-18 Lung cancer; LUSC cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg13010199 chr12:38710504 ALG10B -0.48 -7.41 -0.38 1.01e-12 Morning vs. evening chronotype; LUSC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg05585544 chr11:47624801 NA -0.42 -7.35 -0.37 1.55e-12 Subjective well-being; LUSC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg11764359 chr7:65958608 NA 0.68 10.56 0.5 1.14e-22 Aortic root size; LUSC cis rs3087591 0.708 rs2107359 chr17:29697223 A/T cg24425628 chr17:29625626 OMG;NF1 0.49 7.28 0.37 2.48e-12 Hip circumference; LUSC cis rs6685188 0.925 rs12752037 chr1:205661614 A/C cg14893161 chr1:205819251 PM20D1 -0.43 -6.42 -0.33 4.73e-10 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg01238044 chr22:24384105 GSTT1 -0.53 -7.64 -0.39 2.25e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11122272 0.735 rs2808583 chr1:231512587 G/C cg06096015 chr1:231504339 EGLN1 0.56 9.95 0.48 1.38e-20 Hemoglobin concentration; LUSC cis rs4845459 0.967 rs4112788 chr1:152551276 A/G cg08895932 chr1:152778580 LCE1C -0.35 -5.73 -0.3 2.22e-8 Psoriasis; LUSC cis rs10782582 0.532 rs78106188 chr1:76137836 A/G cg10523679 chr1:76189770 ACADM -0.5 -7.3 -0.37 2.06e-12 Daytime sleep phenotypes; LUSC cis rs372883 0.967 rs2832290 chr21:30728863 C/T cg24692254 chr21:30365293 RNF160 -0.44 -6.16 -0.32 2.14e-9 Pancreatic cancer; LUSC cis rs7607369 0.714 rs4674338 chr2:219647487 A/G cg02176678 chr2:219576539 TTLL4 0.66 13.07 0.58 8.21e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg21856205 chr7:94953877 PON1 -0.36 -5.77 -0.3 1.77e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10791097 0.694 rs7106995 chr11:130758152 G/T cg12179176 chr11:130786555 SNX19 0.87 14.66 0.63 6.69e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs8180040 0.966 rs13072802 chr3:47346415 G/C cg27129171 chr3:47204927 SETD2 0.72 12.42 0.56 2.16e-29 Colorectal cancer; LUSC cis rs4654899 0.680 rs4654881 chr1:21209769 T/C cg01072550 chr1:21505969 NA 0.53 7.88 0.4 4.63e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg04450456 chr4:17643702 FAM184B -0.4 -6.77 -0.35 5.91e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2019216 0.521 rs6565386 chr17:21901755 A/G cg22648282 chr17:21454238 C17orf51 0.45 6.74 0.35 6.87e-11 Pelvic organ prolapse; LUSC cis rs12594515 1.000 rs8032835 chr15:45997897 C/G cg01629716 chr15:45996671 NA 0.4 5.96 0.31 6.25e-9 Waist circumference;Weight; LUSC cis rs1866706 0.896 rs4757955 chr11:12876492 C/A cg25843174 chr11:12811716 TEAD1 -0.28 -5.72 -0.3 2.36e-8 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg05347473 chr6:146136440 FBXO30 -0.5 -8.41 -0.42 1.2e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.09 0.32 3.09e-9 Personality dimensions; LUSC cis rs7267979 1.000 rs2482931 chr20:25334445 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.61 -0.69 1.43e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg00509249 chr6:109615579 CCDC162 -0.34 -6.13 -0.32 2.46e-9 Reticulocyte fraction of red cells; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09104050 chr16:68563912 NA -0.46 -6.16 -0.32 2.1e-9 Bipolar disorder and schizophrenia; LUSC cis rs739401 0.611 rs402276 chr11:3051404 C/G cg08508325 chr11:3079039 CARS -0.52 -12.94 -0.58 2.49e-31 Longevity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27287882 chr3:48282590 ZNF589 0.45 6.39 0.33 5.51e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg02773041 chr1:40204384 PPIE 0.54 8.26 0.41 3.35e-15 Blood protein levels; LUSC cis rs2227564 1 rs2227564 chr10:75673101 C/T cg23231163 chr10:75533350 FUT11 0.42 5.75 0.3 1.97e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs6961069 0.585 rs10265457 chr7:80257373 G/A cg04458919 chr7:80252533 CD36 -0.41 -7.28 -0.37 2.49e-12 Platelet count; LUSC cis rs6570726 0.967 rs9403707 chr6:145800010 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.34 0.56 4.27e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg00409905 chr10:38381863 ZNF37A -0.38 -6.42 -0.33 4.55e-10 Extrinsic epigenetic age acceleration; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg08859206 chr1:53392774 SCP2 -0.64 -12.22 -0.56 1.26e-28 Monocyte count; LUSC cis rs2762353 0.935 rs1183200 chr6:25818646 G/C cg15691649 chr6:25882328 NA -0.37 -5.85 -0.3 1.19e-8 Blood metabolite levels; LUSC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg21573476 chr21:45109991 RRP1B 0.38 5.99 0.31 5.58e-9 Mean corpuscular volume; LUSC trans rs72674100 1.000 rs28368345 chr4:97991439 T/C cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg07362569 chr17:61921086 SMARCD2 0.37 7.62 0.38 2.61e-13 Prudent dietary pattern; LUSC cis rs12042938 0.579 rs980394 chr1:231779507 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.42 -6.24 -0.32 1.35e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs208520 0.874 rs208512 chr6:66943869 C/G cg07460842 chr6:66804631 NA -1.01 -14.3 -0.62 1.55e-36 Exhaled nitric oxide output; LUSC cis rs7246967 0.611 rs66620859 chr19:22837230 G/T cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs12594515 1.000 rs7162201 chr15:45992658 A/C cg19682013 chr15:45996608 NA 0.39 5.86 0.31 1.14e-8 Waist circumference;Weight; LUSC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Melanoma; LUSC cis rs9534288 0.797 rs992631 chr13:46591989 A/G cg15192986 chr13:46630673 CPB2 0.65 10.76 0.51 2.29e-23 Blood protein levels; LUSC cis rs637571 0.522 rs649000 chr11:65742933 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.66 0.47 1.29e-19 Eosinophil percentage of white cells; LUSC cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg23796481 chr11:64053134 BAD;GPR137 0.6 9.89 0.48 2.14e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs10802346 0.545 rs10924568 chr1:246385482 C/A cg13514129 chr1:39547527 MACF1 0.71 11.82 0.54 3.64e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs9616064 0.889 rs5767287 chr22:46996179 G/A cg05621596 chr22:47072043 GRAMD4 -0.43 -6.43 -0.33 4.51e-10 Urate levels in obese individuals; LUSC cis rs8060686 0.641 rs1125333 chr16:68227566 C/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.36 -0.33 6.66e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6582630 0.503 rs4882293 chr12:38388200 G/C cg26384229 chr12:38710491 ALG10B -0.55 -8.3 -0.41 2.53e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs11748023 0.605 rs155948 chr5:139519181 A/G cg26211634 chr5:139558579 C5orf32 -0.35 -6.38 -0.33 5.93e-10 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Melanoma; LUSC cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.51 -7.36 -0.37 1.46e-12 Axial length; LUSC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg03929089 chr4:120376271 NA -0.94 -16.27 -0.66 3.03e-44 Height; LUSC cis rs13031619 0.517 rs10864995 chr2:3683557 C/T cg00999904 chr2:3704751 ALLC -0.43 -5.97 -0.31 6.15e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9815354 0.638 rs111465678 chr3:41864405 C/A cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.6e-10 Pulse pressure;Diastolic blood pressure; LUSC trans rs61931739 0.534 rs1490109 chr12:34064077 T/C cg13010199 chr12:38710504 ALG10B 0.55 8.2 0.41 5.23e-15 Morning vs. evening chronotype; LUSC cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 13.14 0.58 4.43e-32 Alzheimer's disease; LUSC cis rs7615316 0.872 rs7635146 chr3:142350079 A/G cg16271453 chr3:142027066 XRN1 -0.34 -5.82 -0.3 1.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg06764241 chr13:99092976 FARP1 0.52 7.16 0.36 5.05e-12 Cognitive function;Information processing speed; LUSC cis rs8060686 0.641 rs57408712 chr16:68242573 G/C cg09835421 chr16:68378352 PRMT7 -0.52 -5.79 -0.3 1.59e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs12893668 0.608 rs12889721 chr14:104034863 C/T cg01849466 chr14:104193079 ZFYVE21 -0.47 -6.52 -0.34 2.64e-10 Reticulocyte count; LUSC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg16339924 chr4:17578868 LAP3 0.57 8.79 0.43 8.02e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs796364 0.512 rs1653290 chr2:201078165 A/T cg23649088 chr2:200775458 C2orf69 0.61 7.84 0.39 6.01e-14 Schizophrenia; LUSC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg02782426 chr3:40428986 ENTPD3 0.31 6.02 0.31 4.57e-9 Renal cell carcinoma; LUSC cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg09184832 chr6:79620586 NA -0.42 -6.8 -0.35 4.71e-11 Intelligence (multi-trait analysis); LUSC trans rs11992162 0.560 rs13256329 chr8:11782214 G/A cg14343924 chr8:8086146 FLJ10661 -0.45 -6.23 -0.32 1.43e-9 Monocyte count; LUSC cis rs2439831 1.000 rs2439831 chr15:43784475 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.52 0.42 5.65e-16 Lung cancer in ever smokers; LUSC cis rs7169223 0.653 rs3743057 chr15:79089007 T/C cg21242079 chr15:79101063 ADAMTS7 0.42 6.32 0.33 8.44e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2455601 1.000 rs72632952 chr11:8917976 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -7.85 -0.39 5.64e-14 Schizophrenia; LUSC cis rs1440410 0.798 rs10002867 chr4:144169650 G/T cg01719995 chr4:144104893 USP38 0.33 5.79 0.3 1.6e-8 Ischemic stroke; LUSC cis rs9399135 0.660 rs9376072 chr6:135280519 G/C cg22676075 chr6:135203613 NA 0.55 8.73 0.43 1.25e-16 Red blood cell count; LUSC cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs9287719 0.935 rs7600495 chr2:10739800 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC trans rs9329221 0.537 rs2062332 chr8:9980024 G/A cg15556689 chr8:8085844 FLJ10661 0.54 8.06 0.4 1.37e-14 Neuroticism; LUSC cis rs11098499 0.604 rs2389886 chr4:120570422 C/T cg09307838 chr4:120376055 NA 0.68 9.54 0.46 3.11e-19 Corneal astigmatism; LUSC cis rs9868809 0.649 rs3733086 chr3:48699519 C/T cg00383909 chr3:49044727 WDR6 1.14 9.53 0.46 3.4e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs68170813 0.641 rs34084719 chr7:107095227 A/G cg02696742 chr7:106810147 HBP1 -0.62 -8.76 -0.43 9.65e-17 Coronary artery disease; LUSC cis rs9325144 0.505 rs1906262 chr12:38653605 A/G cg26384229 chr12:38710491 ALG10B 0.8 13.26 0.59 1.6e-32 Morning vs. evening chronotype; LUSC cis rs8032315 0.965 rs12906125 chr15:91427612 G/A cg04510874 chr15:91427884 FES 0.3 5.93 0.31 7.51e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9549260 0.755 rs4943800 chr13:41216831 A/G cg21288729 chr13:41239152 FOXO1 0.66 10.17 0.49 2.4e-21 Red blood cell count; LUSC cis rs1215050 0.846 rs783923 chr4:98968686 C/T cg05340658 chr4:99064831 C4orf37 -0.43 -6.57 -0.34 1.88e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7254114 0.578 rs3745682 chr19:11313256 C/T cg02815516 chr19:11306319 KANK2 -0.41 -8.41 -0.42 1.21e-15 Immature fraction of reticulocytes; LUSC cis rs6684514 1.000 rs10908500 chr1:156280671 A/T cg16558208 chr1:156270281 VHLL 0.36 5.75 0.3 2e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs1372520 0.684 rs2583963 chr4:90727088 C/T cg01966878 chr4:90757139 SNCA -0.43 -6.22 -0.32 1.49e-9 Neuroticism; LUSC cis rs13315871 0.615 rs6794695 chr3:58423498 A/C cg12435725 chr3:58293450 RPP14 -0.4 -5.65 -0.3 3.52e-8 Cholesterol, total; LUSC cis rs2282032 0.527 rs8020828 chr14:90768183 C/T cg04374321 chr14:90722782 PSMC1 0.44 6.06 0.31 3.63e-9 Longevity; LUSC cis rs12760731 0.720 rs10913557 chr1:178442190 C/T cg00404053 chr1:178313656 RASAL2 0.6 6.3 0.33 9.21e-10 Obesity-related traits; LUSC cis rs2806561 0.808 rs2294518 chr1:23372771 T/C cg19743168 chr1:23544995 NA -0.44 -9.02 -0.44 1.5e-17 Height; LUSC cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.35e-22 Alzheimer's disease (late onset); LUSC cis rs62400317 1.000 rs62400317 chr6:45284923 C/T cg18551225 chr6:44695536 NA -0.42 -6.97 -0.36 1.69e-11 Total body bone mineral density; LUSC cis rs12940923 0.872 rs11650865 chr17:56364741 G/T cg19466818 chr17:56409534 MIR142 -0.39 -6.86 -0.35 3.35e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg19346786 chr7:2764209 NA -0.42 -7.07 -0.36 9.39e-12 Height; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg20592144 chr17:80049216 FASN -0.39 -5.97 -0.31 6e-9 N-glycan levels; LUSC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg21238619 chr17:78079768 GAA -0.45 -8.16 -0.41 6.77e-15 Yeast infection; LUSC cis rs10028773 0.700 rs7690338 chr4:120256468 C/G cg09307838 chr4:120376055 NA 0.69 10.47 0.5 2.2e-22 Educational attainment; LUSC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18404041 chr3:52824283 ITIH1 -0.54 -10.45 -0.5 2.56e-22 Electroencephalogram traits; LUSC cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC trans rs1997103 0.954 rs2177807 chr7:55391002 G/T cg20935933 chr6:143382018 AIG1 -0.45 -6.78 -0.35 5.56e-11 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg25110423 chr6:41068646 NFYA;LOC221442 0.45 7.4 0.38 1.12e-12 Alzheimer's disease (late onset); LUSC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg06112835 chr11:68658793 MRPL21 0.48 7.02 0.36 1.21e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs629535 0.547 rs62513420 chr8:70122597 G/A cg21567404 chr3:27674614 NA -0.9 -12.79 -0.57 8.93e-31 Dupuytren's disease; LUSC cis rs1577917 0.740 rs9450302 chr6:86289673 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 9.33 0.45 1.57e-18 Response to antipsychotic treatment; LUSC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06634786 chr22:41940651 POLR3H -0.53 -6.23 -0.32 1.37e-9 Vitiligo; LUSC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg20684491 chr1:25596433 NA -0.36 -5.72 -0.3 2.42e-8 Erythrocyte sedimentation rate; LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg14092988 chr3:52407081 DNAH1 0.31 5.97 0.31 6.11e-9 Bipolar disorder; LUSC cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.64 0.57 3.36e-30 Motion sickness; LUSC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17994379 chr17:43025264 KIF18B 0.55 7.83 0.39 6.69e-14 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg27279351 chr12:120934652 DYNLL1 0.58 7.72 0.39 1.39e-13 High light scatter reticulocyte count; LUSC cis rs8017423 0.967 rs11844225 chr14:90726676 G/A cg14092571 chr14:90743983 NA -0.36 -5.82 -0.3 1.37e-8 Mortality in heart failure; LUSC cis rs10089 1.000 rs4836370 chr5:127499224 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.89 12.78 0.57 1.02e-30 Ileal carcinoids; LUSC cis rs8180040 0.966 rs11711824 chr3:47468261 C/T cg16586182 chr3:47516702 SCAP -0.51 -8.03 -0.4 1.74e-14 Colorectal cancer; LUSC cis rs9467773 0.838 rs3734540 chr6:26463321 A/C cg11502198 chr6:26597334 ABT1 0.52 7.67 0.39 1.91e-13 Intelligence (multi-trait analysis); LUSC cis rs4903214 0.848 rs11627178 chr14:74718280 G/C cg08255017 chr14:74727001 VSX2 -0.49 -6.72 -0.35 7.93e-11 Inflammatory bowel disease; LUSC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg02569458 chr12:86230093 RASSF9 -0.49 -8.08 -0.4 1.23e-14 Major depressive disorder; LUSC cis rs7131987 0.650 rs10843377 chr12:29437053 C/G cg09582351 chr12:29534625 ERGIC2 0.34 6.93 0.35 2.15e-11 QT interval; LUSC trans rs1486139 0.967 rs4724464 chr7:46296433 A/G cg17534202 chr9:96721102 NA -0.36 -6.51 -0.34 2.82e-10 Select biomarker traits; LUSC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg13628971 chr7:2884303 GNA12 0.49 6.83 0.35 4e-11 Height; LUSC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg04944784 chr2:26401820 FAM59B -0.67 -9.71 -0.47 8.72e-20 Gut microbiome composition (summer); LUSC cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg06784218 chr1:46089804 CCDC17 0.48 9.53 0.46 3.45e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1178968 0.901 rs4717753 chr7:72754354 C/T cg25889504 chr7:72793014 NA 0.53 7.25 0.37 2.95e-12 Triglyceride levels; LUSC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg03909863 chr11:638404 DRD4 -0.39 -5.74 -0.3 2.17e-8 Systemic lupus erythematosus; LUSC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg02931644 chr1:25747376 RHCE -0.32 -5.76 -0.3 1.89e-8 Erythrocyte sedimentation rate; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg11845071 chr6:35695859 FKBP5;LOC285847 0.4 6.11 0.32 2.79e-9 N-glycan levels; LUSC cis rs4595586 0.545 rs3914595 chr12:39388530 G/T cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs3859192 0.561 rs12451547 chr17:38181168 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.69 0.57 2.12e-30 White blood cell count; LUSC cis rs9326248 0.581 rs7106437 chr11:116992076 T/C cg16524733 chr11:117070046 TAGLN 0.31 5.92 0.31 8.15e-9 Blood protein levels; LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03352830 chr11:487213 PTDSS2 0.73 8.7 0.43 1.54e-16 Body mass index; LUSC cis rs3106136 0.967 rs35670996 chr4:95199479 C/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.18 -0.32 1.91e-9 Capecitabine sensitivity; LUSC trans rs2243480 1.000 rs316327 chr7:65609201 G/T cg10756647 chr7:56101905 PSPH -0.82 -8.56 -0.42 4.12e-16 Diabetic kidney disease; LUSC cis rs1577917 0.727 rs2758840 chr6:86304625 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.88 -0.51 8.15e-24 Response to antipsychotic treatment; LUSC cis rs72781680 0.851 rs72796397 chr2:24178211 T/A cg08917208 chr2:24149416 ATAD2B 0.91 10.18 0.49 2.2e-21 Lymphocyte counts; LUSC cis rs11155671 0.530 rs7757984 chr6:150208651 A/G cg13206674 chr6:150067644 NUP43 0.43 6.4 0.33 5.31e-10 Testicular germ cell tumor; LUSC cis rs17125944 0.505 rs17125746 chr14:53236079 C/T cg13660082 chr14:53194042 PSMC6 -0.8 -6.65 -0.34 1.17e-10 Alzheimer's disease (late onset); LUSC cis rs7524258 0.900 rs6577425 chr1:7306338 G/T cg07173049 chr1:7289937 CAMTA1 0.32 6.56 0.34 2.01e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs4629180 0.675 rs6742474 chr2:102091075 G/A cg04415270 chr2:102091202 RFX8 -0.46 -8.08 -0.4 1.18e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs9902453 0.769 rs7210288 chr17:28243473 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.33 0.45 1.56e-18 Coffee consumption (cups per day); LUSC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg00814883 chr7:100076585 TSC22D4 -0.68 -9.45 -0.46 6.18e-19 Platelet count; LUSC cis rs4845459 1.000 rs4845459 chr1:152603842 C/A cg08895932 chr1:152778580 LCE1C -0.36 -5.8 -0.3 1.56e-8 Psoriasis; LUSC cis rs12908161 1.000 rs11637142 chr15:85295927 A/G cg17173187 chr15:85201210 NMB 0.5 9.39 0.46 9.83e-19 Schizophrenia; LUSC cis rs17433780 0.857 rs12144445 chr1:89465238 C/T cg09516651 chr1:89888402 LOC400759 0.49 8.12 0.41 8.9e-15 Carotid intima media thickness; LUSC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7954584 0.523 rs11043280 chr12:122426643 T/C cg21171335 chr12:122356390 WDR66 0.61 9.13 0.45 6.84e-18 Mean corpuscular volume; LUSC cis rs9929218 0.520 rs1078621 chr16:68778996 C/T cg01251360 chr16:68772225 CDH1 -0.26 -6.28 -0.32 1.06e-9 Colorectal cancer; LUSC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg10295955 chr4:187884368 NA -1.08 -25.56 -0.81 1.33e-80 Lobe attachment (rater-scored or self-reported); LUSC trans rs2243480 1.000 rs958550 chr7:65635679 C/T cg10756647 chr7:56101905 PSPH -0.88 -8.46 -0.42 8.54e-16 Diabetic kidney disease; LUSC cis rs60154123 0.614 rs662424 chr1:210458472 T/C cg22029157 chr1:209979665 IRF6 0.51 6.02 0.31 4.63e-9 Coronary artery disease; LUSC cis rs4803468 1.000 rs10413735 chr19:41921071 C/T cg09537434 chr19:41945824 ATP5SL -0.91 -15.71 -0.65 4.87e-42 Height; LUSC cis rs757081 0.667 rs615424 chr11:17210481 G/A cg15432903 chr11:17409602 KCNJ11 -0.38 -5.94 -0.31 7.29e-9 Systolic blood pressure; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13377803 chr19:5978247 RANBP3 0.7 6.29 0.33 9.94e-10 Cognitive performance; LUSC trans rs11148252 0.532 rs9536262 chr13:53303074 A/C cg18335740 chr13:41363409 SLC25A15 -0.73 -13.2 -0.59 2.6e-32 Lewy body disease; LUSC cis rs17030434 0.953 rs74845915 chr4:154696778 G/T cg14289246 chr4:154710475 SFRP2 -0.51 -6.65 -0.34 1.19e-10 Electrocardiographic conduction measures; LUSC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg14895029 chr7:2775587 GNA12 -0.37 -5.81 -0.3 1.43e-8 Height; LUSC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg11812906 chr14:75593930 NEK9 -0.63 -10.39 -0.49 4.36e-22 Height; LUSC cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs760805 1.000 rs4648884 chr1:25261386 C/T cg22509179 chr1:25234806 RUNX3 0.6 10.24 0.49 1.41e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg11279151 chr3:101281821 RG9MTD1 -0.41 -6.11 -0.32 2.8e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg16339924 chr4:17578868 LAP3 0.52 7.93 0.4 3.3e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs2562456 0.833 rs7260065 chr19:21516977 A/G cg00806126 chr19:22604979 ZNF98 -0.42 -6.03 -0.31 4.3e-9 Pain; LUSC cis rs13385 0.769 rs7705932 chr5:139533115 G/A cg26211634 chr5:139558579 C5orf32 0.42 5.96 0.31 6.48e-9 Atrial fibrillation; LUSC cis rs8072100 0.967 rs11079784 chr17:45702280 A/G cg08085267 chr17:45401833 C17orf57 0.53 8.53 0.42 5.04e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC trans rs62103177 0.714 rs28691615 chr18:77612254 C/T cg05926928 chr17:57297772 GDPD1 1.09 13.61 0.6 7.39e-34 Opioid sensitivity; LUSC cis rs13315871 0.929 rs9871725 chr3:58292525 T/G cg12435725 chr3:58293450 RPP14 -0.76 -7.66 -0.39 2.07e-13 Cholesterol, total; LUSC cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg26384229 chr12:38710491 ALG10B 0.89 15.03 0.64 2.37e-39 Bladder cancer; LUSC cis rs1949733 0.523 rs62287455 chr4:8544994 A/T cg13073564 chr4:8508604 NA 0.35 6.45 0.33 3.9e-10 Response to antineoplastic agents; LUSC cis rs4319547 0.620 rs12372756 chr12:122815130 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.29 -0.45 1.98e-18 Body mass index; LUSC cis rs9399401 0.961 rs9389985 chr6:142653898 A/G cg03128060 chr6:142623767 GPR126 0.31 5.68 0.3 3e-8 Chronic obstructive pulmonary disease; LUSC cis rs838147 0.537 rs632111 chr19:49208978 A/G cg21064579 chr19:49206444 FUT2 0.44 8.56 0.42 4.29e-16 Dietary macronutrient intake; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg06675538 chr2:114033490 PAX8;LOC440839 -0.32 -5.85 -0.31 1.14e-8 Lymphocyte counts; LUSC trans rs2278907 0.898 rs4531478 chr11:68482489 A/G cg10806483 chr12:102459329 NA -0.33 -6.22 -0.32 1.5e-9 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17156855 chr1:168195023 SFT2D2 -0.4 -6.0 -0.31 5.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7267979 0.866 rs2424698 chr20:25256106 C/T cg08601574 chr20:25228251 PYGB 0.46 7.07 0.36 8.84e-12 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9944715 0.906 rs7505861 chr18:43745406 A/G cg01718231 chr17:29326311 RNF135 0.47 6.63 0.34 1.37e-10 Red cell distribution width;Mean corpuscular volume; LUSC cis rs10743315 0.557 rs16915108 chr12:19290406 T/C cg02471346 chr12:19282374 PLEKHA5 0.96 6.92 0.35 2.29e-11 Gut microbiota (bacterial taxa); LUSC cis rs2227564 0.678 rs2242257 chr10:75597605 A/G cg23231163 chr10:75533350 FUT11 0.42 5.79 0.3 1.66e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9311676 0.656 rs6445973 chr3:58336595 G/T cg13750441 chr3:58318267 PXK -0.31 -5.67 -0.3 3.1e-8 Systemic lupus erythematosus; LUSC cis rs9837602 1.000 rs28714363 chr3:99752068 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.09 -0.32 3.14e-9 Breast cancer; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg14331148 chr19:47551893 TMEM160 0.37 5.94 0.31 6.98e-9 Calcium levels; LUSC cis rs6088580 0.505 rs6058106 chr20:33278255 T/C cg08999081 chr20:33150536 PIGU -0.4 -7.35 -0.37 1.54e-12 Glomerular filtration rate (creatinine); LUSC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg06145435 chr7:1022769 CYP2W1 0.34 5.75 0.3 1.98e-8 Bronchopulmonary dysplasia; LUSC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg16339924 chr4:17578868 LAP3 0.55 8.42 0.42 1.12e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs722599 0.683 rs10144845 chr14:75237770 C/T cg08847533 chr14:75593920 NEK9 0.44 6.3 0.33 9.25e-10 IgG glycosylation; LUSC cis rs6987853 0.933 rs2923401 chr8:42442208 T/C cg09913449 chr8:42400586 C8orf40 0.47 7.67 0.39 1.86e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs7267979 0.816 rs3746337 chr20:25208272 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.63 11.59 0.54 2.47e-26 Liver enzyme levels (alkaline phosphatase); LUSC cis rs500891 0.574 rs4706994 chr6:84126824 G/A cg08257003 chr6:84140564 ME1 0.37 8.9 0.44 3.73e-17 Platelet-derived growth factor BB levels; LUSC cis rs34779708 0.897 rs4934716 chr10:35369299 A/G cg04310649 chr10:35416472 CREM -0.41 -6.47 -0.33 3.5e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8028313 0.630 rs28418298 chr15:67935745 C/T cg05925327 chr15:68127851 NA -0.43 -6.82 -0.35 4.18e-11 Obesity; LUSC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg00784671 chr22:46762841 CELSR1 -0.54 -6.94 -0.35 2.07e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs9814567 1.000 rs6801596 chr3:134252114 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.25 -0.59 1.75e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1949733 1.000 rs2631758 chr4:8495304 G/A cg13073564 chr4:8508604 NA 0.46 8.74 0.43 1.17e-16 Response to antineoplastic agents; LUSC cis rs7633770 0.710 rs34820891 chr3:46698059 A/G cg11219411 chr3:46661640 NA -0.34 -6.48 -0.33 3.39e-10 Coronary artery disease; LUSC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg04317338 chr11:64019027 PLCB3 0.68 7.75 0.39 1.12e-13 Mean platelet volume; LUSC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg11812906 chr14:75593930 NEK9 -0.63 -10.35 -0.49 5.99e-22 Height; LUSC cis rs7605827 0.930 rs10929376 chr2:15692856 A/T cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs460214 0.539 rs55819392 chr21:40038207 G/A cg05519781 chr21:40033154 ERG -0.43 -5.7 -0.3 2.58e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs240764 0.817 rs239221 chr6:101113085 G/A cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs7666738 0.570 rs10032272 chr4:99095601 T/C cg03676636 chr4:99064102 C4orf37 0.27 5.8 0.3 1.58e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg04025307 chr7:1156635 C7orf50 0.4 6.53 0.34 2.49e-10 Longevity;Endometriosis; LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.12 0.66 1.24e-43 Platelet count; LUSC cis rs7202877 0.610 rs7202284 chr16:75374346 A/T cg03315344 chr16:75512273 CHST6 0.41 5.84 0.3 1.22e-8 Type 2 diabetes;Type 1 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04135372 chr2:99061383 INPP4A -0.55 -6.69 -0.34 9.37e-11 Bipolar disorder and schizophrenia; LUSC cis rs12438659 1 rs12438659 chr15:78824924 G/A cg06917634 chr15:78832804 PSMA4 -0.58 -7.05 -0.36 1.04e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9527 0.590 rs11191553 chr10:104851396 G/T cg05855489 chr10:104503620 C10orf26 0.52 7.96 0.4 2.72e-14 Arsenic metabolism; LUSC cis rs9790314 0.690 rs9860738 chr3:160843290 G/A cg03342759 chr3:160939853 NMD3 -0.42 -6.83 -0.35 3.91e-11 Morning vs. evening chronotype; LUSC cis rs8141529 0.732 rs2239815 chr22:29192670 C/T cg15103426 chr22:29168792 CCDC117 -0.54 -7.25 -0.37 3e-12 Lymphocyte counts; LUSC cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg05985134 chr18:33552581 C18orf21 0.5 6.77 0.35 5.96e-11 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs2243480 1.000 rs57057549 chr7:65405738 A/G cg10756647 chr7:56101905 PSPH 0.87 8.46 0.42 8.27e-16 Diabetic kidney disease; LUSC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg05025164 chr4:1340916 KIAA1530 0.49 7.78 0.39 9.33e-14 Obesity-related traits; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg16325326 chr1:53192061 ZYG11B 0.81 14.3 0.62 1.62e-36 Monocyte count; LUSC cis rs3772130 0.962 rs1920320 chr3:121547527 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.19 0.49 1.99e-21 Cognitive performance; LUSC cis rs7577696 0.568 rs115985725 chr2:32335807 G/A cg02381751 chr2:32503542 YIPF4 -0.4 -5.67 -0.3 3.06e-8 Inflammatory biomarkers; LUSC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.15 0.45 5.97e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs9815354 0.767 rs73081335 chr3:41895177 A/G cg03022575 chr3:42003672 ULK4 0.84 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9814567 1.000 rs62271513 chr3:134298412 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.85 13.93 0.61 4.46e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg04944784 chr2:26401820 FAM59B -0.69 -9.7 -0.47 9.44e-20 Gut microbiome composition (summer); LUSC cis rs4631830 0.863 rs10826127 chr10:51530757 G/A cg16070123 chr10:51489643 NA -0.53 -8.4 -0.42 1.31e-15 Prostate-specific antigen levels; LUSC cis rs637571 0.584 rs594689 chr11:65635559 G/A cg26695010 chr11:65641043 EFEMP2 0.6 8.98 0.44 1.96e-17 Eosinophil percentage of white cells; LUSC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg08499158 chr17:42289980 UBTF -0.55 -8.46 -0.42 8.37e-16 Total body bone mineral density; LUSC cis rs9929218 0.551 rs2281850 chr16:68718750 C/T cg01251360 chr16:68772225 CDH1 0.27 6.72 0.35 7.71e-11 Colorectal cancer; LUSC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg13902645 chr11:5959945 NA -0.53 -7.45 -0.38 8.17e-13 DNA methylation (variation); LUSC cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg26597838 chr10:835615 NA 0.63 8.05 0.4 1.45e-14 Eosinophil percentage of granulocytes; LUSC cis rs6005807 0.719 rs12169460 chr22:29042079 A/G cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg12826209 chr6:26865740 GUSBL1 -0.55 -7.92 -0.4 3.48e-14 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg24209194 chr3:40518798 ZNF619 -0.45 -5.82 -0.3 1.36e-8 Renal cell carcinoma; LUSC cis rs7592578 0.723 rs4371384 chr2:191430741 A/G cg10560079 chr2:191398806 TMEM194B 0.74 9.19 0.45 4.15e-18 Diastolic blood pressure; LUSC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg12927641 chr6:109611667 NA 0.35 5.89 0.31 9.29e-9 Reticulocyte fraction of red cells; LUSC trans rs1997103 1.000 rs6973450 chr7:55396537 A/G cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg24558204 chr6:135376177 HBS1L -0.6 -8.74 -0.43 1.14e-16 High light scatter reticulocyte percentage of red cells; LUSC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg06212747 chr3:49208901 KLHDC8B 0.45 6.17 0.32 1.94e-9 Parkinson's disease; LUSC cis rs611744 0.608 rs612744 chr8:109245991 G/A cg21045802 chr8:109455806 TTC35 0.43 6.56 0.34 2e-10 Dupuytren's disease; LUSC cis rs877282 0.945 rs10904554 chr10:786768 T/C cg17470449 chr10:769945 NA 0.49 6.71 0.34 8.1e-11 Uric acid levels; LUSC cis rs765787 0.530 rs4775822 chr15:45527127 A/G cg24006582 chr15:45444508 DUOX1 -0.61 -9.03 -0.44 1.43e-17 Uric acid levels; LUSC cis rs12042938 0.600 rs4658880 chr1:231764621 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 5.95 0.31 6.63e-9 Neuranatomic and neurocognitive phenotypes; LUSC trans rs10506458 0.834 rs73125186 chr12:63373400 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.13 -14.31 -0.62 1.52e-36 Hemostatic factors and hematological phenotypes; LUSC cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.7 8.29 0.41 2.81e-15 Lung function (FEV1/FVC); LUSC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg09323728 chr8:95962352 TP53INP1 -0.39 -7.79 -0.39 8.44e-14 Type 2 diabetes; LUSC cis rs4631830 0.540 rs2843562 chr10:51496796 A/G cg16070123 chr10:51489643 NA 0.59 10.29 0.49 9.5e-22 Prostate-specific antigen levels; LUSC cis rs13191362 0.507 rs7772787 chr6:163190981 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.41 8.17 0.41 6.58e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2108225 0.900 rs2051956 chr7:107441358 G/C cg18560240 chr7:107437656 SLC26A3 -0.38 -5.73 -0.3 2.27e-8 Ulcerative colitis; LUSC trans rs6104690 0.967 rs6074225 chr20:10982994 A/G cg07172334 chr21:31655261 KRTAP24-1 -0.34 -6.11 -0.32 2.85e-9 Bladder cancer; LUSC cis rs7937682 0.924 rs10891286 chr11:111532691 C/G cg22437258 chr11:111473054 SIK2 0.5 6.82 0.35 4.3e-11 Primary sclerosing cholangitis; LUSC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg12365402 chr11:9010492 NRIP3 0.45 8.26 0.41 3.33e-15 Hemoglobin concentration; LUSC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.54 -0.34 2.34e-10 Schizophrenia; LUSC cis rs231513 1.000 rs231518 chr17:41961451 C/T cg26893861 chr17:41843967 DUSP3 0.59 6.67 0.34 1.05e-10 Cognitive function; LUSC cis rs67478160 0.634 rs2144079 chr14:104258884 C/T cg08213375 chr14:104286397 PPP1R13B 0.45 8.76 0.43 9.72e-17 Schizophrenia; LUSC cis rs782590 0.967 rs6545506 chr2:55798108 A/G cg18811423 chr2:55921094 PNPT1 -0.82 -14.41 -0.62 6.05e-37 Metabolic syndrome; LUSC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC cis rs9891119 0.631 rs963987 chr17:40561679 A/G cg16308533 chr17:40838983 CNTNAP1 -0.38 -5.7 -0.3 2.67e-8 Multiple sclerosis;Crohn's disease; LUSC cis rs7264396 0.635 rs6060660 chr20:34476649 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.41 -0.42 1.18e-15 Total cholesterol levels; LUSC cis rs7223966 1.000 rs3817181 chr17:61776538 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.56 0.34 2.08e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs67539049 1.000 rs73546312 chr8:11302709 G/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.4 -6.2 -0.32 1.63e-9 Itch intensity from mosquito bite; LUSC cis rs1559088 0.847 rs2287679 chr19:33600764 T/C cg03563238 chr19:33554763 RHPN2 -0.4 -6.43 -0.33 4.3e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs769267 0.566 rs9304962 chr19:19679992 G/C cg03709012 chr19:19516395 GATAD2A -0.51 -7.32 -0.37 1.84e-12 Tonsillectomy; LUSC cis rs9513627 0.833 rs73556146 chr13:100116920 A/G cg25919922 chr13:100150906 NA -0.74 -6.22 -0.32 1.52e-9 Obesity-related traits; LUSC cis rs1153858 1.000 rs1153849 chr15:45695695 G/A cg21132104 chr15:45694354 SPATA5L1 0.56 7.84 0.39 6.29e-14 Homoarginine levels; LUSC cis rs55665837 1.000 rs10832269 chr11:14465069 C/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.54 -0.38 4.47e-13 Vitamin D levels; LUSC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg03609598 chr5:56110824 MAP3K1 -0.43 -6.11 -0.32 2.83e-9 Type 2 diabetes; LUSC cis rs4595586 0.545 rs3858553 chr12:39381291 A/C cg26384229 chr12:38710491 ALG10B 0.52 7.36 0.37 1.42e-12 Morning vs. evening chronotype; LUSC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg16989086 chr20:62203971 PRIC285 0.45 6.34 0.33 7.32e-10 Glioblastoma; LUSC cis rs72781680 0.898 rs116113042 chr2:23960194 G/T cg08917208 chr2:24149416 ATAD2B 0.88 9.72 0.47 7.6e-20 Lymphocyte counts; LUSC cis rs2562456 0.834 rs2173727 chr19:21673957 C/T cg00806126 chr19:22604979 ZNF98 0.38 5.9 0.31 9.06e-9 Pain; LUSC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs17854409 0.764 rs8116995 chr20:61475824 A/G cg05147244 chr20:61493195 TCFL5 0.8 6.51 0.34 2.75e-10 Obesity-related traits; LUSC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg08847533 chr14:75593920 NEK9 -0.85 -15.79 -0.65 2.44e-42 Height; LUSC cis rs1577917 0.740 rs7752502 chr6:86410651 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.98 0.44 2.09e-17 Response to antipsychotic treatment; LUSC cis rs644799 0.562 rs654345 chr11:95581865 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.09 0.45 9.27e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6693567 0.565 rs12731296 chr1:150411787 A/G cg15654264 chr1:150340011 RPRD2 0.44 7.11 0.36 7.28e-12 Migraine; LUSC cis rs2404602 0.647 rs11072620 chr15:77048770 T/A cg23625390 chr15:77176239 SCAPER -0.66 -10.06 -0.48 5.61e-21 Blood metabolite levels; LUSC cis rs2348418 0.864 rs2203088 chr12:28709700 G/A cg13890972 chr12:28721907 NA -0.35 -6.18 -0.32 1.88e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.16 -0.32 2.1e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.88e-19 Developmental language disorder (linguistic errors); LUSC cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg05283184 chr6:79620031 NA -0.54 -10.73 -0.51 2.83e-23 Intelligence (multi-trait analysis); LUSC cis rs6084875 0.840 rs743252 chr20:4720667 C/T cg26097573 chr20:4721490 PRNT -0.31 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg11984989 chr7:158649758 WDR60 1.08 22.23 0.77 7.93e-68 Height; LUSC cis rs2835872 0.930 rs2835880 chr21:39032477 A/G cg20424643 chr21:39039972 KCNJ6 0.49 7.39 0.37 1.19e-12 Electroencephalographic traits in alcoholism; LUSC cis rs61931739 0.500 rs11053268 chr12:34545121 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.86 0.58 5.05e-31 Platelet count; LUSC cis rs68170813 0.527 rs75382408 chr7:107010406 C/T cg02696742 chr7:106810147 HBP1 -0.6 -9.1 -0.45 8.27e-18 Coronary artery disease; LUSC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg05234568 chr11:5960015 NA -0.54 -8.63 -0.43 2.63e-16 DNA methylation (variation); LUSC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg21433313 chr16:3507492 NAT15 -0.39 -6.15 -0.32 2.22e-9 Body mass index (adult); LUSC cis rs1348850 0.668 rs6734426 chr2:178493770 C/T cg22681709 chr2:178499509 PDE11A -0.51 -8.47 -0.42 8.04e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3768617 0.510 rs2296288 chr1:183072590 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.75 0.51 2.31e-23 Fuchs's corneal dystrophy; LUSC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg22875332 chr1:76189707 ACADM -0.72 -9.93 -0.48 1.57e-20 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7481584 0.669 rs12793371 chr11:3034709 A/G cg25174290 chr11:3078921 CARS -0.41 -6.14 -0.32 2.29e-9 Calcium levels; LUSC cis rs997295 0.554 rs4261477 chr15:68073968 G/T cg08079166 chr15:68083412 MAP2K5 0.37 7.81 0.39 7.47e-14 Motion sickness; LUSC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg10523679 chr1:76189770 ACADM 0.89 14.21 0.61 3.54e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10876993 0.672 rs2640611 chr12:58037757 T/A cg15848620 chr12:58087721 OS9 -0.53 -7.55 -0.38 4.14e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.566 rs2842611 chr6:86302034 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -5.8 -0.3 1.5e-8 Response to antipsychotic treatment; LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 13.32 0.59 8.96e-33 Platelet count; LUSC trans rs1027479 0.842 rs3019341 chr8:109721351 T/C cg14904725 chr13:113777045 F10 -0.25 -6.11 -0.32 2.78e-9 Facial morphology (factor 6, height of vermillion lower lip); LUSC cis rs5770917 1.000 rs3180872 chr22:51017394 G/C cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.58 -5.73 -0.3 2.21e-8 Narcolepsy; LUSC cis rs7465272 1.000 rs7835613 chr8:143682428 C/T cg01509843 chr8:143695822 ARC 0.41 6.36 0.33 6.59e-10 Bipolar disorder and schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01741397 chr15:89786926 FANCI 0.48 6.82 0.35 4.34e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.79e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs3812762 0.871 rs3844100 chr11:8817808 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.37 6.06 0.31 3.71e-9 Hypospadias; LUSC cis rs10779751 0.690 rs28729193 chr1:11180151 T/C cg08854313 chr1:11322531 MTOR -0.82 -12.92 -0.58 3.14e-31 Body mass index; LUSC trans rs7824557 0.767 rs6985460 chr8:11171087 A/C cg15556689 chr8:8085844 FLJ10661 0.56 8.44 0.42 1.01e-15 Retinal vascular caliber; LUSC cis rs6582630 0.599 rs1589392 chr12:38418535 G/C cg26384229 chr12:38710491 ALG10B -0.55 -8.22 -0.41 4.49e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg04155289 chr7:94953770 PON1 -0.34 -5.69 -0.3 2.72e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9486719 1.000 rs72931061 chr6:96880285 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg07701084 chr6:150067640 NUP43 0.56 8.64 0.43 2.28e-16 Lung cancer; LUSC cis rs73058052 1.000 rs73057994 chr19:50091273 C/A cg09250473 chr19:50168907 IRF3;BCL2L12 0.53 6.11 0.32 2.81e-9 Fibrinogen levels; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg01012244 chr7:127344973 SND1 0.38 6.24 0.32 1.35e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7647973 1.000 rs2177268 chr3:49439725 A/T cg07636037 chr3:49044803 WDR6 -0.69 -9.12 -0.45 6.98e-18 Menarche (age at onset); LUSC cis rs3857536 0.740 rs9354390 chr6:66890162 C/T cg07460842 chr6:66804631 NA 0.45 6.36 0.33 6.71e-10 Blood trace element (Cu levels); LUSC cis rs3770081 1.000 rs73943920 chr2:86186195 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.0 -6.34 -0.33 7.31e-10 Facial emotion recognition (sad faces); LUSC cis rs9346649 0.967 rs6907103 chr6:168490016 C/T cg02770688 chr6:168491649 NA -0.4 -7.61 -0.38 2.78e-13 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs72717009 0.825 rs9427397 chr1:161476204 C/T cg23840854 chr1:161414152 NA -0.92 -11.22 -0.52 5.42e-25 Rheumatoid arthritis; LUSC cis rs8141529 0.584 rs58004020 chr22:29257050 A/T cg15103426 chr22:29168792 CCDC117 0.58 7.68 0.39 1.77e-13 Lymphocyte counts; LUSC cis rs6998277 1.000 rs35155104 chr8:103646559 G/T cg10187029 chr8:103597600 NA 0.65 8.46 0.42 8.6e-16 Migraine; LUSC cis rs9287719 0.967 rs6759740 chr2:10747271 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs12928939 0.517 rs12445641 chr16:71967783 C/T cg03805757 chr16:71968109 PKD1L3 -0.64 -9.8 -0.47 4.31e-20 Post bronchodilator FEV1; LUSC cis rs1150668 0.796 rs2531825 chr6:28349264 C/T cg21251018 chr6:28226885 NKAPL 0.31 5.79 0.3 1.59e-8 Pubertal anthropometrics; LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg11940773 chr11:63606512 MARK2 0.43 6.59 0.34 1.69e-10 Bladder cancer; LUSC cis rs9487051 0.766 rs351748 chr6:109532296 C/T cg01475377 chr6:109611718 NA 0.37 6.34 0.33 7.25e-10 Reticulocyte fraction of red cells; LUSC cis rs7824557 0.767 rs2060463 chr8:11161610 T/G cg21293242 chr8:11204541 TDH 0.32 5.95 0.31 6.93e-9 Retinal vascular caliber; LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg18099408 chr3:52552593 STAB1 -0.39 -6.68 -0.34 1.03e-10 Bipolar disorder; LUSC cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg09184832 chr6:79620586 NA -0.44 -7.0 -0.36 1.41e-11 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08976749 chr12:49716792 TROAP 0.74 5.98 0.31 5.85e-9 Cognitive performance; LUSC cis rs3008870 0.701 rs2815367 chr1:67500762 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.54 0.57 8.04e-30 Lymphocyte percentage of white cells; LUSC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg19257562 chr1:2043853 PRKCZ 0.33 6.72 0.35 7.85e-11 Height; LUSC cis rs1823874 0.720 rs2003037 chr15:100361962 G/T cg16400843 chr15:100339927 C15orf51 0.36 7.21 0.37 3.77e-12 IgG glycosylation; LUSC cis rs711244 0.756 rs2372786 chr2:37159799 A/G cg14987922 chr2:37194071 STRN 0.43 6.19 0.32 1.8e-9 Mean platelet volume; LUSC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.6 8.43 0.42 1.05e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.24e-12 Platelet count; LUSC cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg24558204 chr6:135376177 HBS1L 0.68 10.64 0.5 6.01e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg22467129 chr15:76604101 ETFA -0.49 -7.76 -0.39 1.03e-13 Blood metabolite levels; LUSC cis rs2295359 0.892 rs6688383 chr1:67655954 C/T cg17031739 chr1:67600172 NA -0.44 -6.57 -0.34 1.98e-10 Psoriasis; LUSC cis rs11098499 0.909 rs78332141 chr4:120375782 C/T cg24375607 chr4:120327624 NA 0.77 10.99 0.52 3.44e-24 Corneal astigmatism; LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC cis rs10791097 0.694 rs4459316 chr11:130756176 T/C cg12179176 chr11:130786555 SNX19 0.85 14.75 0.63 2.97e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1153858 1.000 rs1145085 chr15:45657804 A/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.28 0.49 1.04e-21 Homoarginine levels; LUSC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg16325326 chr1:53192061 ZYG11B 0.91 16.87 0.68 1.3e-46 Monocyte count; LUSC cis rs12421382 0.659 rs1371330 chr11:109382692 G/T cg16359550 chr11:109292809 C11orf87 0.37 6.31 0.33 8.71e-10 Schizophrenia; LUSC cis rs4356932 1.000 rs4859587 chr4:76943296 A/C cg00809888 chr4:76862425 NAAA 0.35 5.78 0.3 1.72e-8 Blood protein levels; LUSC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg22823121 chr1:150693482 HORMAD1 0.53 8.05 0.4 1.49e-14 Melanoma; LUSC cis rs7647973 1.000 rs62259933 chr3:49469703 G/A cg07636037 chr3:49044803 WDR6 -0.69 -8.98 -0.44 2.07e-17 Menarche (age at onset); LUSC cis rs5758511 0.773 rs12167978 chr22:42346475 G/A cg00645731 chr22:42541494 CYP2D7P1 0.45 7.39 0.37 1.17e-12 Birth weight; LUSC cis rs73200209 0.744 rs17426970 chr12:116665099 T/C cg01776926 chr12:116560359 MED13L -0.49 -6.05 -0.31 3.97e-9 Total body bone mineral density; LUSC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs12541335 0.603 rs9792127 chr8:22180334 G/A cg02463440 chr8:22132932 PIWIL2 0.42 7.61 0.38 2.85e-13 Hypertriglyceridemia; LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg18099408 chr3:52552593 STAB1 -0.41 -7.13 -0.36 6.38e-12 Bipolar disorder; LUSC cis rs7188861 0.724 rs443299 chr16:11372656 G/A cg00044050 chr16:11439710 C16orf75 0.53 6.01 0.31 4.85e-9 HDL cholesterol; LUSC cis rs11209185 0.503 rs4655573 chr1:68438778 C/T cg22082780 chr1:68452167 NA -0.43 -7.12 -0.36 6.55e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs6782228 0.606 rs2712404 chr3:128332679 C/T cg16766828 chr3:128327626 NA 0.32 5.77 0.3 1.83e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs10193935 0.901 rs1439231 chr2:42542884 G/A cg27598129 chr2:42591480 NA -0.59 -8.43 -0.42 1.07e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs751728 0.664 rs4711347 chr6:33735292 G/A cg25922239 chr6:33757077 LEMD2 0.41 5.98 0.31 5.67e-9 Crohn's disease; LUSC cis rs5769765 0.862 rs9616774 chr22:50290599 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.05 0.36 1.02e-11 Schizophrenia; LUSC trans rs7556950 0.572 rs79273885 chr2:41931372 C/T cg13792581 chr20:43590115 TOMM34 0.74 6.27 0.32 1.12e-9 Major depression and alcohol dependence; LUSC cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.13 0.48 3.32e-21 Bladder cancer; LUSC trans rs853679 0.607 rs13199649 chr6:27868792 C/T cg06606381 chr12:133084897 FBRSL1 -1.03 -8.88 -0.44 4.15e-17 Depression; LUSC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg21782813 chr7:2030301 MAD1L1 0.5 8.44 0.42 9.76e-16 Bipolar disorder and schizophrenia; LUSC cis rs2742417 1.000 rs1877934 chr3:45753295 G/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg14664628 chr15:75095509 CSK -0.57 -8.58 -0.42 3.72e-16 Breast cancer; LUSC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg14582100 chr15:45693742 SPATA5L1 0.58 10.64 0.5 5.72e-23 Homoarginine levels; LUSC cis rs4285028 0.603 rs79312528 chr3:121608997 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.81 -10.63 -0.5 6.17e-23 Multiple sclerosis; LUSC cis rs9616064 0.531 rs17821649 chr22:47050387 G/A cg25730555 chr22:47059586 GRAMD4 0.45 7.07 0.36 9.04e-12 Urate levels in obese individuals; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg10862848 chr6:42927986 GNMT -0.28 -6.57 -0.34 1.91e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs67072384 0.901 rs11235580 chr11:72455645 G/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg22166914 chr1:53195759 ZYG11B -0.61 -10.3 -0.49 8.6e-22 Monocyte count; LUSC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg24209194 chr3:40518798 ZNF619 0.43 5.78 0.3 1.69e-8 Renal cell carcinoma; LUSC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg22875332 chr1:76189707 ACADM -0.82 -13.97 -0.61 2.9e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4629180 0.540 rs6747670 chr2:102130368 T/C cg01388757 chr2:102091195 RFX8 -0.36 -6.25 -0.32 1.25e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.78 -0.39 9.4e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs55665837 0.922 rs12287212 chr11:14449861 C/A cg05501817 chr11:14380813 RRAS2 -0.4 -6.48 -0.33 3.23e-10 Vitamin D levels; LUSC trans rs7937682 0.924 rs12791699 chr11:111505880 T/C cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs10782582 0.609 rs2881785 chr1:76318096 T/C cg10523679 chr1:76189770 ACADM -0.49 -7.14 -0.36 5.93e-12 Daytime sleep phenotypes; LUSC cis rs4730250 0.655 rs4727671 chr7:106876045 A/G cg02696742 chr7:106810147 HBP1 -0.63 -9.48 -0.46 5.01e-19 Osteoarthritis; LUSC cis rs7582720 1.000 rs72934706 chr2:203707752 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.75 8.14 0.41 8e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.11 0.32 2.79e-9 Schizophrenia; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -5.79 -0.3 1.64e-8 Developmental language disorder (linguistic errors); LUSC cis rs7833986 0.501 rs72653981 chr8:57027814 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.12 0.55 2.99e-28 Height; LUSC cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs2658782 0.756 rs3019223 chr11:93084182 G/A cg15737290 chr11:93063684 CCDC67 0.68 8.4 0.42 1.29e-15 Pulmonary function decline; LUSC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg13798780 chr7:105162888 PUS7 0.56 6.07 0.32 3.43e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2637266 0.935 rs2252661 chr10:78404793 A/G cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg09177884 chr7:1199841 ZFAND2A 0.45 6.19 0.32 1.73e-9 Longevity;Endometriosis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11516594 chr18:3013156 LPIN2 -0.43 -6.4 -0.33 5.41e-10 Electrocardiographic conduction measures; LUSC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg15649852 chr7:65879115 NA 0.41 5.76 0.3 1.93e-8 Aortic root size; LUSC cis rs4494114 1.000 rs7539067 chr1:39359694 A/G cg25970120 chr1:39325951 RRAGC -0.37 -5.98 -0.31 5.59e-9 Blood protein levels; LUSC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg22875332 chr1:76189707 ACADM -0.86 -14.1 -0.61 9.4e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg14552801 chr7:65878734 NA -0.44 -6.18 -0.32 1.85e-9 Aortic root size; LUSC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg18402987 chr7:1209562 NA 0.43 5.77 0.3 1.83e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs61931739 0.612 rs1906136 chr12:33905293 C/T cg06521331 chr12:34319734 NA -0.39 -6.44 -0.33 4.16e-10 Morning vs. evening chronotype; LUSC cis rs983392 0.805 rs7116190 chr11:59964992 G/A cg20284999 chr11:59952153 MS4A6A -0.39 -6.4 -0.33 5.12e-10 Alzheimer's disease (late onset); LUSC cis rs6964587 0.967 rs58673519 chr7:91823887 T/G cg17063962 chr7:91808500 NA 0.58 8.92 0.44 3.2e-17 Breast cancer; LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg20607798 chr8:58055168 NA 0.54 6.22 0.32 1.5e-9 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs7312938 chr12:34378708 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.4 0.49 3.9e-22 Morning vs. evening chronotype; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14576616 chr7:91763911 CYP51A1 0.48 6.3 0.33 9.45e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg02423579 chr7:2872169 GNA12 -0.47 -6.73 -0.35 7.52e-11 Height; LUSC cis rs8114671 0.836 rs2425012 chr20:33581955 G/A cg07148914 chr20:33460835 GGT7 -0.45 -6.58 -0.34 1.86e-10 Height; LUSC cis rs9309473 0.583 rs11126397 chr2:73588733 C/T cg20560298 chr2:73613845 ALMS1 -0.54 -7.96 -0.4 2.79e-14 Metabolite levels; LUSC cis rs1113500 0.965 rs10881495 chr1:108610986 C/A cg06207961 chr1:108661230 NA 0.4 7.29 0.37 2.3e-12 Growth-regulated protein alpha levels; LUSC cis rs10876993 0.928 rs2640637 chr12:58077586 G/A cg18357645 chr12:58087776 OS9 0.58 8.67 0.43 1.94e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs6964587 0.869 rs13237856 chr7:91551788 G/A cg17063962 chr7:91808500 NA -0.53 -8.18 -0.41 6.03e-15 Breast cancer; LUSC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.35 -0.8 4.97e-76 Height; LUSC trans rs4148689 0.951 rs4148706 chr7:117190996 T/G cg10450175 chr16:88689712 ZC3H18 0.46 5.99 0.31 5.37e-9 Gout; LUSC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.3 0.45 1.84e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17826219 0.500 rs57005940 chr17:29066329 C/G cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Body mass index; LUSC cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.25 0.49 1.34e-21 Bladder cancer; LUSC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg24881330 chr22:46731750 TRMU 0.84 6.69 0.34 9.33e-11 LDL cholesterol;Cholesterol, total; LUSC trans rs6582630 0.519 rs11181526 chr12:38360230 A/G cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.28e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs7824557 0.545 rs2572380 chr8:11237477 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.19e-14 Retinal vascular caliber; LUSC cis rs1595825 0.891 rs74965164 chr2:198499162 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg22709100 chr7:91322751 NA 0.43 6.33 0.33 8.02e-10 Breast cancer; LUSC cis rs7618501 1.000 rs3749241 chr3:49744392 A/G cg24110177 chr3:50126178 RBM5 0.42 6.66 0.34 1.1e-10 Intelligence (multi-trait analysis); LUSC cis rs78572108 0.858 rs4952397 chr2:42266513 T/A cg00607755 chr2:42274082 PKDCC 0.36 6.47 0.33 3.56e-10 Total body bone mineral density; LUSC cis rs13082711 0.911 rs17682751 chr3:27497027 C/T cg02860705 chr3:27208620 NA -0.48 -8.38 -0.42 1.52e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs1325195 0.879 rs2816187 chr1:179101606 C/G cg11624085 chr17:8464688 MYH10 0.44 7.34 0.37 1.65e-12 IgE grass sensitization; LUSC cis rs9393777 0.528 rs9467989 chr6:27064275 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.37 -6.01 -0.31 4.88e-9 Intelligence (multi-trait analysis); LUSC cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg00701064 chr4:6280414 WFS1 0.62 16.31 0.67 2.18e-44 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24425829 chr1:59250882 JUN -0.46 -5.99 -0.31 5.31e-9 Bipolar disorder and schizophrenia; LUSC cis rs6684514 1.000 rs12041164 chr1:156279811 G/A cg16558208 chr1:156270281 VHLL 0.35 5.67 0.3 3.1e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs826838 1.000 rs826891 chr12:39100824 A/G cg13010199 chr12:38710504 ALG10B -0.64 -10.89 -0.51 7.99e-24 Heart rate; LUSC cis rs7617773 0.780 rs11714176 chr3:48360862 C/T cg11946769 chr3:48343235 NME6 0.88 14.18 0.61 4.69e-36 Coronary artery disease; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.6 -0.38 2.98e-13 Lymphocyte counts; LUSC cis rs11971779 0.616 rs7784192 chr7:139039649 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9905704 0.831 rs12949598 chr17:56707245 C/T cg12560992 chr17:57184187 TRIM37 0.55 7.85 0.39 5.74e-14 Testicular germ cell tumor; LUSC cis rs6138458 1.000 rs6106984 chr20:24977006 T/C cg26195577 chr20:24973756 C20orf3 1.11 18.48 0.71 5e-53 Blood protein levels; LUSC trans rs7769051 0.808 rs1467404 chr6:133090141 A/G cg27275811 chr11:74457193 NA 0.6 6.06 0.31 3.73e-9 Type 2 diabetes nephropathy; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03705947 chr1:68152081 GADD45A 0.41 6.19 0.32 1.79e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs853679 0.546 rs200977 chr6:27854301 T/C cg08798685 chr6:27730294 NA -0.7 -6.08 -0.32 3.22e-9 Depression; LUSC cis rs67478160 0.634 rs941473 chr14:104201869 C/G cg01849466 chr14:104193079 ZFYVE21 -0.62 -10.36 -0.49 5.42e-22 Schizophrenia; LUSC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg09877947 chr5:131593287 PDLIM4 -0.44 -6.63 -0.34 1.37e-10 Breast cancer; LUSC cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg13010199 chr12:38710504 ALG10B 0.7 11.76 0.54 5.86e-27 Heart rate; LUSC cis rs17270561 0.887 rs12201170 chr6:25866247 A/G cg17042849 chr6:26104293 HIST1H4C -0.49 -5.77 -0.3 1.83e-8 Iron status biomarkers; LUSC cis rs28829049 0.597 rs1009806 chr1:19500551 T/C cg13387374 chr1:19411106 UBR4 0.44 6.23 0.32 1.39e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs9462027 0.628 rs2296360 chr6:34803558 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.03 -0.31 4.26e-9 Systemic lupus erythematosus; LUSC cis rs9650657 0.812 rs11250074 chr8:10632259 A/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.56 -0.34 1.99e-10 Neuroticism; LUSC cis rs7095944 0.614 rs61872084 chr10:126439062 C/T cg08799069 chr10:126477246 METTL10 -0.41 -6.34 -0.33 7.51e-10 Asthma; LUSC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg23093090 chr10:104574429 C10orf26 -0.43 -7.65 -0.39 2.21e-13 Arsenic metabolism; LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs2625529 0.641 rs11852789 chr15:72265494 G/C cg16672083 chr15:72433130 SENP8 -0.51 -7.39 -0.37 1.19e-12 Red blood cell count; LUSC cis rs611744 0.647 rs2594358 chr8:109256018 A/G cg21045802 chr8:109455806 TTC35 0.44 6.73 0.35 7.27e-11 Dupuytren's disease; LUSC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9300255 0.602 rs10744147 chr12:123643729 A/G cg13010344 chr12:123464640 ARL6IP4 -0.47 -5.91 -0.31 8.29e-9 Neutrophil percentage of white cells; LUSC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg11764359 chr7:65958608 NA -0.5 -6.37 -0.33 6.12e-10 Aortic root size; LUSC trans rs9650657 0.504 rs10109167 chr8:11033525 C/T cg15556689 chr8:8085844 FLJ10661 -0.57 -8.56 -0.42 4.06e-16 Neuroticism; LUSC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs61931739 0.817 rs1705771 chr12:34174950 C/G cg06521331 chr12:34319734 NA -0.34 -5.9 -0.31 8.73e-9 Morning vs. evening chronotype; LUSC cis rs981844 0.712 rs1037646 chr4:154738015 C/T cg14289246 chr4:154710475 SFRP2 -0.44 -6.13 -0.32 2.46e-9 Response to statins (LDL cholesterol change); LUSC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.66 0.47 1.26e-19 Height; LUSC cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg05340658 chr4:99064831 C4orf37 0.57 9.54 0.46 3.03e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs12681288 0.576 rs6990403 chr8:963471 C/A cg04851639 chr8:1020857 NA -0.39 -7.72 -0.39 1.4e-13 Schizophrenia; LUSC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg12365402 chr11:9010492 NRIP3 -0.51 -9.78 -0.47 4.9e-20 Hemoglobin concentration; LUSC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg25456477 chr12:86230367 RASSF9 0.33 5.82 0.3 1.39e-8 Major depressive disorder; LUSC cis rs950169 0.580 rs62021208 chr15:85196244 G/A cg17507749 chr15:85114479 UBE2QP1 0.59 7.51 0.38 5.32e-13 Schizophrenia; LUSC cis rs9467773 1.000 rs2393670 chr6:26535541 A/G cg09904177 chr6:26538194 HMGN4 0.76 14.42 0.62 5.75e-37 Intelligence (multi-trait analysis); LUSC cis rs7246657 0.882 rs4803539 chr19:37897522 A/C cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg11244672 chr19:19639970 YJEFN3 0.6 7.33 0.37 1.72e-12 Bipolar disorder; LUSC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg06453172 chr10:134556979 INPP5A -0.5 -6.35 -0.33 6.9e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg18854424 chr1:2615690 NA -0.47 -9.29 -0.45 2.02e-18 Ulcerative colitis; LUSC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg11742103 chr11:62369870 EML3;MTA2 0.48 7.35 0.37 1.52e-12 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs2230307 0.536 rs629340 chr1:100538621 A/T cg24955406 chr1:100503596 HIAT1 0.59 6.44 0.33 4.23e-10 Carotid intima media thickness; LUSC cis rs7582180 1.000 rs4851285 chr2:100907598 A/G cg08017756 chr2:100939284 LONRF2 -0.36 -6.07 -0.32 3.49e-9 Intelligence (multi-trait analysis); LUSC cis rs12973672 1.000 rs10414846 chr19:35772471 A/G cg12095397 chr19:35769544 USF2 -0.46 -7.06 -0.36 9.77e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs28588043 0.652 rs11486179 chr1:170957028 C/A cg07135042 chr19:56905152 ZNF582 -0.6 -6.33 -0.33 8.08e-10 Number of children (6+ vs. 0 or 1); LUSC cis rs12579753 0.956 rs7959951 chr12:82231132 T/C cg21231944 chr12:82153410 PPFIA2 -0.38 -5.76 -0.3 1.94e-8 Resting heart rate; LUSC cis rs7212590 0.748 rs7220187 chr17:57897609 C/T cg10252138 chr17:58120427 NA -0.74 -7.0 -0.36 1.39e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.05 -0.36 1.02e-11 Colorectal cancer; LUSC cis rs17685 0.753 rs10952840 chr7:75772878 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs8060686 0.641 rs76419201 chr16:68153553 G/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.4 -0.38 1.12e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs1595825 0.891 rs16825917 chr2:198805185 C/T cg00982548 chr2:198649783 BOLL -0.58 -7.22 -0.37 3.57e-12 Ulcerative colitis; LUSC cis rs2777491 0.915 rs28526381 chr15:41621842 A/C cg18705301 chr15:41695430 NDUFAF1 -0.73 -13.36 -0.59 6.47e-33 Ulcerative colitis; LUSC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.55 -0.34 2.24e-10 Lung cancer; LUSC cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg08999081 chr20:33150536 PIGU 0.51 10.3 0.49 8.95e-22 Glomerular filtration rate (creatinine); LUSC cis rs3540 0.574 rs2526000 chr15:90962626 C/T cg10434728 chr15:90938212 IQGAP1 0.4 8.36 0.42 1.7e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg26335602 chr6:28129616 ZNF389 -0.44 -5.97 -0.31 5.97e-9 Parkinson's disease; LUSC cis rs7712401 0.601 rs246275 chr5:122231413 C/T cg19077854 chr5:122220652 SNX24 0.4 8.65 0.43 2.2e-16 Mean platelet volume; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.56 0.42 4.18e-16 Prudent dietary pattern; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.91 0.4 3.77e-14 Prudent dietary pattern; LUSC trans rs1728785 0.901 rs2862781 chr16:68639234 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.72 0.39 1.39e-13 Ulcerative colitis; LUSC cis rs7246967 0.673 rs4933036 chr19:22963069 C/A cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg14664628 chr15:75095509 CSK -0.56 -8.75 -0.43 1.04e-16 Breast cancer; LUSC cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg01256987 chr12:42539512 GXYLT1 -0.45 -8.45 -0.42 8.92e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7200543 1.000 rs16966952 chr16:15135943 C/T cg03427771 chr16:15082598 PDXDC1 -0.4 -5.68 -0.3 2.9e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs11690935 0.959 rs10194102 chr2:172626143 G/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.37 -0.62 8.79e-37 Schizophrenia; LUSC cis rs977987 0.902 rs34539062 chr16:75493279 C/A cg04384234 chr16:75411784 CFDP1 -0.48 -7.87 -0.4 5.05e-14 Dupuytren's disease; LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.55 8.51 0.42 5.91e-16 Lymphocyte counts; LUSC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg26587870 chr6:27730563 NA -0.56 -5.69 -0.3 2.84e-8 Breast cancer; LUSC cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC cis rs11122272 0.668 rs1122131 chr1:231476501 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.57 -0.42 3.81e-16 Hemoglobin concentration; LUSC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg09699651 chr6:150184138 LRP11 0.45 7.16 0.36 5.11e-12 Testicular germ cell tumor; LUSC cis rs9300255 0.602 rs1790131 chr12:123701010 G/T cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg20607798 chr8:58055168 NA 0.54 7.16 0.36 5.1e-12 Developmental language disorder (linguistic errors); LUSC cis rs11650494 0.908 rs77338752 chr17:47372328 A/C cg08112188 chr17:47440006 ZNF652 1.21 10.4 0.49 4.01e-22 Prostate cancer; LUSC cis rs17095355 1.000 rs55781439 chr10:111670220 C/T cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.2 -0.37 3.93e-12 Biliary atresia; LUSC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs9487051 0.768 rs445796 chr6:109520145 T/C cg00509249 chr6:109615579 CCDC162 -0.34 -5.88 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.71 12.06 0.55 4.64e-28 Prudent dietary pattern; LUSC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg18876405 chr7:65276391 NA 0.54 8.22 0.41 4.42e-15 Aortic root size; LUSC trans rs7829975 0.624 rs7823056 chr8:8382705 A/G cg21775007 chr8:11205619 TDH 0.45 6.73 0.35 7.52e-11 Mood instability; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg21724239 chr8:58056113 NA 0.78 8.56 0.42 4.04e-16 Developmental language disorder (linguistic errors); LUSC cis rs7903847 0.667 rs11189181 chr10:99144154 A/G cg08345082 chr10:99160200 RRP12 -0.38 -7.45 -0.38 7.85e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs4268898 0.931 rs55642516 chr2:24502305 A/G cg06627628 chr2:24431161 ITSN2 -0.61 -9.12 -0.45 7.02e-18 Asthma; LUSC cis rs7917772 0.560 rs10786697 chr10:104378563 G/T cg05855489 chr10:104503620 C10orf26 -0.49 -7.4 -0.38 1.11e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7100689 0.599 rs946892 chr10:82127551 C/T cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs9311676 0.656 rs12495490 chr3:58373251 A/G cg26110898 chr3:58419937 PDHB 0.41 6.69 0.34 9.67e-11 Systemic lupus erythematosus; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg07677032 chr17:61819896 STRADA 0.56 9.26 0.45 2.62e-18 Prudent dietary pattern; LUSC cis rs34891900 0.507 rs9605364 chr22:18127437 G/A cg08824373 chr22:18117835 NA -0.44 -6.71 -0.34 8.56e-11 Sum neutrophil eosinophil counts; LUSC cis rs4363385 0.818 rs10888526 chr1:153000311 G/T cg25856811 chr1:152973957 SPRR3 -0.36 -6.02 -0.31 4.57e-9 Inflammatory skin disease; LUSC cis rs3540 0.576 rs10152871 chr15:91047469 G/A cg10434728 chr15:90938212 IQGAP1 -0.45 -8.94 -0.44 2.63e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg26441486 chr22:50317300 CRELD2 -0.55 -8.28 -0.41 2.94e-15 Schizophrenia; LUSC cis rs2073300 0.609 rs6137936 chr20:23385232 C/T cg12062639 chr20:23401060 NAPB 0.94 8.24 0.41 3.94e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg00166722 chr3:10149974 C3orf24 0.54 7.0 0.36 1.43e-11 Alzheimer's disease; LUSC cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg08601574 chr20:25228251 PYGB 0.44 6.75 0.35 6.5e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs68170813 0.559 rs11769861 chr7:106979559 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.66 -0.3 3.35e-8 Coronary artery disease; LUSC cis rs12594515 1.000 rs6493167 chr15:45986809 G/A cg19682013 chr15:45996608 NA 0.4 6.05 0.31 3.83e-9 Waist circumference;Weight; LUSC cis rs11098499 0.730 rs12505735 chr4:120532956 G/T cg24375607 chr4:120327624 NA 0.7 10.58 0.5 9.42e-23 Corneal astigmatism; LUSC cis rs10504073 0.669 rs62507253 chr8:50028836 C/T cg00325661 chr8:49890786 NA 0.61 9.5 0.46 4.27e-19 Blood metabolite ratios; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01357671 chr17:3626806 ITGAE;GSG2 0.47 6.82 0.35 4.3e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.69 -11.54 -0.53 3.77e-26 Systemic lupus erythematosus; LUSC cis rs7119038 0.774 rs874621 chr11:118655645 G/A cg19308663 chr11:118741387 NA 0.39 6.64 0.34 1.25e-10 Sjögren's syndrome; LUSC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.94 0.4 3.04e-14 Parkinson's disease; LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs7917772 0.582 rs4919661 chr10:104358403 T/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.26e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg17911788 chr17:44343683 NA -0.31 -5.99 -0.31 5.3300000000000004e-09 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6733011 0.508 rs4850889 chr2:99521385 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.93 -0.35 2.15e-11 Bipolar disorder; LUSC cis rs11971779 0.648 rs10230407 chr7:139103893 A/G cg07862535 chr7:139043722 LUC7L2 0.55 6.76 0.35 6.16e-11 Diisocyanate-induced asthma; LUSC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg26897989 chr16:1907736 C16orf73 -0.43 -6.28 -0.32 1.08e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7917772 0.582 rs4919661 chr10:104358403 T/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.42 -0.38 9.5e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7011192 0.793 rs11774104 chr8:10526434 C/G cg17329886 chr8:10513629 RP1L1 -0.72 -7.78 -0.39 8.94e-14 Suicide; LUSC cis rs3796619 1.000 rs3796619 chr4:1095281 A/G cg27284194 chr4:1044797 NA 0.5 8.02 0.4 1.75e-14 Recombination rate (males); LUSC cis rs7089973 0.604 rs7914792 chr10:116591391 T/C cg03647239 chr10:116582469 FAM160B1 0.45 7.27 0.37 2.55e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6087990 0.814 rs2424895 chr20:31335978 C/T cg13636640 chr20:31349939 DNMT3B -0.93 -19.76 -0.73 4.02e-58 Ulcerative colitis; LUSC cis rs4601821 0.789 rs7123797 chr11:113262571 A/G cg14159747 chr11:113255604 NA 0.25 6.06 0.31 3.75e-9 Alcoholic chronic pancreatitis; LUSC cis rs17818399 0.926 rs1824050 chr2:46839477 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.44 -5.85 -0.31 1.15e-8 Height; LUSC cis rs2295359 0.892 rs72676069 chr1:67658954 T/C cg03340356 chr1:67600835 NA 0.44 6.82 0.35 4.25e-11 Psoriasis; LUSC cis rs11098499 0.754 rs714899 chr4:120243035 G/A cg09307838 chr4:120376055 NA 0.69 10.42 0.5 3.26e-22 Corneal astigmatism; LUSC cis rs983392 0.679 rs1026255 chr11:60029949 A/G cg02771260 chr11:59836817 MS4A3 -0.37 -6.13 -0.32 2.52e-9 Alzheimer's disease (late onset); LUSC cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg17691542 chr6:26056736 HIST1H1C -0.73 -9.49 -0.46 4.39e-19 Iron status biomarkers; LUSC cis rs4363385 0.720 rs1611764 chr1:152957887 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.69 -0.39 1.68e-13 Inflammatory skin disease; LUSC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg26944245 chr16:421049 TMEM8A;MRPL28 0.41 6.18 0.32 1.87e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg06552810 chr11:31128660 NA -0.41 -7.25 -0.37 2.89e-12 Red blood cell count; LUSC cis rs400736 0.562 rs12711516 chr1:8181227 G/C cg25007680 chr1:8021821 PARK7 -0.42 -6.05 -0.31 3.87e-9 Response to antidepressants and depression; LUSC cis rs7216064 1.000 rs56404791 chr17:65893019 T/G cg12091567 chr17:66097778 LOC651250 -0.72 -9.62 -0.47 1.68e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg07424592 chr7:64974309 NA 0.66 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC trans rs7613875 0.580 rs12634780 chr3:50043341 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.46 -7.32 -0.37 1.91e-12 Body mass index; LUSC cis rs977987 0.931 rs1424013 chr16:75495986 T/C cg04384234 chr16:75411784 CFDP1 -0.48 -7.83 -0.39 6.46e-14 Dupuytren's disease; LUSC cis rs11190604 1.000 rs10883497 chr10:102228519 A/G cg16342193 chr10:102329863 NA -0.34 -6.22 -0.32 1.47e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4974559 0.847 rs28477912 chr4:1331350 C/T cg02980000 chr4:1222292 CTBP1 0.76 7.35 0.37 1.49e-12 Systolic blood pressure; LUSC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg06637938 chr14:75390232 RPS6KL1 0.52 8.29 0.41 2.85e-15 Height; LUSC cis rs3812111 0.510 rs1569824 chr6:116590802 T/A cg18828861 chr6:116576566 TSPYL4 0.38 6.71 0.34 8.55e-11 Age-related macular degeneration; LUSC cis rs10979 1.000 rs1416205 chr6:143889397 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs9467773 1.000 rs4713006 chr6:26519872 A/G cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.64e-42 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg24829409 chr8:58192753 C8orf71 -0.64 -7.83 -0.39 6.64e-14 Developmental language disorder (linguistic errors); LUSC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg03060546 chr3:49711283 APEH 0.72 11.83 0.54 3.25e-27 Resting heart rate; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05554353 chr6:126277910 HINT3 -0.49 -5.97 -0.31 6.16e-9 Bipolar disorder and schizophrenia; LUSC cis rs3617 0.539 rs9985365 chr3:52953844 A/G cg11645453 chr3:52864694 ITIH4 -0.36 -8.1 -0.41 1.03e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg06713675 chr4:122721982 EXOSC9 -0.55 -9.44 -0.46 6.48e-19 Type 2 diabetes; LUSC cis rs6754311 0.731 rs748841 chr2:136558157 C/T cg07169764 chr2:136633963 MCM6 -0.6 -7.86 -0.4 5.34e-14 Mosquito bite size; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17185823 chr8:11324806 FAM167A -0.44 -6.09 -0.32 3.13e-9 Hepatitis; LUSC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg23172400 chr8:95962367 TP53INP1 -0.3 -5.77 -0.3 1.82e-8 Type 2 diabetes; LUSC trans rs61931739 0.500 rs7955247 chr12:34126580 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.56 0.42 4.15e-16 Morning vs. evening chronotype; LUSC trans rs9944715 1.000 rs7239351 chr18:43851338 A/T cg01718231 chr17:29326311 RNF135 -0.49 -7.02 -0.36 1.24e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg01483505 chr11:975446 AP2A2 0.42 5.9 0.31 9.15e-9 Alzheimer's disease (late onset); LUSC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.84 0.54 3e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs10838798 0.517 rs1967210 chr11:48096692 G/T cg15704280 chr7:45808275 SEPT13 -0.65 -6.78 -0.35 5.58e-11 Height; LUSC cis rs10464366 0.510 rs62442212 chr7:39146896 A/C cg18850127 chr7:39170497 POU6F2 0.59 9.48 0.46 4.96e-19 IgG glycosylation; LUSC cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg05347473 chr6:146136440 FBXO30 0.5 8.43 0.42 1.07e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs877282 0.898 rs35743076 chr10:758991 C/T cg17470449 chr10:769945 NA 0.52 7.47 0.38 6.99e-13 Uric acid levels; LUSC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg17366294 chr4:99064904 C4orf37 0.55 9.61 0.47 1.79e-19 Colonoscopy-negative controls vs population controls; LUSC trans rs10511400 0.541 rs12152218 chr3:119878877 A/G cg02809009 chr19:50354510 PTOV1 -0.67 -6.11 -0.32 2.71e-9 Economic and political preferences (feminism/equality); LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.36 5.65 0.3 3.49e-8 Lymphocyte counts; LUSC cis rs11583043 0.958 rs12746722 chr1:101464789 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.89 0.31 9.64e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs965469 1.000 rs6051732 chr20:3294182 G/A cg25506879 chr20:3388711 C20orf194 -0.52 -5.67 -0.3 3.14e-8 IFN-related cytopenia; LUSC trans rs11098499 0.954 rs7681544 chr4:120411255 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.58 0.34 1.81e-10 Corneal astigmatism; LUSC cis rs4969178 0.895 rs2292640 chr17:76396610 G/A cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs16937 0.574 rs10900455 chr1:205123534 T/C cg00857998 chr1:205179979 DSTYK 0.47 6.79 0.35 5.19e-11 Schizophrenia; LUSC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.65 13.51 0.59 1.7e-33 Monocyte percentage of white cells; LUSC cis rs11039100 0.850 rs34930440 chr11:5834157 A/T cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11155671 0.530 rs9968871 chr6:150209196 G/A cg09699651 chr6:150184138 LRP11 0.45 6.99 0.36 1.46e-11 Testicular germ cell tumor; LUSC cis rs752010 0.806 rs1109255 chr1:42091708 C/T cg06885757 chr1:42089581 HIVEP3 0.49 10.16 0.49 2.51e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7904985 1.000 rs7904985 chr10:88116479 A/G cg07322936 chr10:88137208 NA 0.56 7.06 0.36 9.87e-12 Barrett's esophagus; LUSC cis rs7582180 0.627 rs6542947 chr2:100999647 C/G cg08017756 chr2:100939284 LONRF2 0.33 5.86 0.31 1.1e-8 Intelligence (multi-trait analysis); LUSC cis rs61931739 0.534 rs11053010 chr12:34093228 G/A cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.31 -0.33 9.06e-10 Life satisfaction; LUSC cis rs4642101 0.561 rs9831765 chr3:12805934 A/T cg05775895 chr3:12838266 CAND2 0.48 7.5 0.38 5.95e-13 QRS complex (12-leadsum); LUSC trans rs6982636 1.000 rs2980882 chr8:126480700 A/G cg13325919 chr3:181432053 SOX2;SOX2OT -0.34 -6.54 -0.34 2.34e-10 Lipid metabolism phenotypes; LUSC cis rs2797160 0.547 rs10872298 chr6:125956348 A/C cg05901451 chr6:126070800 HEY2 -0.42 -5.91 -0.31 8.39e-9 Endometrial cancer; LUSC cis rs11971779 0.616 rs10278377 chr7:139103071 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg01802117 chr1:53393560 SCP2 -0.41 -6.83 -0.35 4.01e-11 Monocyte count; LUSC trans rs2898290 0.622 rs13272061 chr8:11352261 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.28 -0.41 3.1e-15 Systolic blood pressure; LUSC trans rs7824557 0.564 rs2572389 chr8:11236392 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.66e-10 Retinal vascular caliber; LUSC cis rs3091242 0.933 rs1534954 chr1:25761924 A/T cg27572855 chr1:25598939 RHD 0.43 7.61 0.38 2.8e-13 Erythrocyte sedimentation rate; LUSC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg00012203 chr2:219082015 ARPC2 0.7 11.64 0.54 1.61e-26 Colorectal cancer; LUSC cis rs9906944 0.545 rs1994969 chr17:47080431 G/T cg10950924 chr17:47092072 IGF2BP1 -0.37 -5.75 -0.3 1.98e-8 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg03517284 chr6:25882590 NA -0.52 -9.75 -0.47 6.07e-20 Blood metabolite levels; LUSC cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg05347473 chr6:146136440 FBXO30 0.46 7.97 0.4 2.55e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs853679 0.517 rs9393901 chr6:28136797 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg02551604 chr5:131831745 NA -0.42 -6.8 -0.35 4.69e-11 Asthma (sex interaction); LUSC cis rs4400599 0.805 rs12063830 chr1:154150911 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.4 -6.48 -0.33 3.31e-10 Platelet distribution width; LUSC cis rs9788682 0.694 rs10851906 chr15:78774676 A/G cg18825076 chr15:78729989 IREB2 0.46 6.45 0.33 4.04e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.38 -0.37 1.25e-12 Glomerular filtration rate (creatinine); LUSC trans rs17685 0.753 rs11982200 chr7:75714883 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.75 0.73 4.46e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg03806693 chr22:41940476 POLR3H -0.86 -12.64 -0.57 3.35e-30 Vitiligo; LUSC cis rs7584330 0.910 rs6757376 chr2:238400036 G/C cg16989719 chr2:238392110 NA -0.38 -6.48 -0.33 3.25e-10 Prostate cancer; LUSC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg27572855 chr1:25598939 RHD 0.41 7.35 0.37 1.58e-12 Erythrocyte sedimentation rate; LUSC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.8 0.39 8.08e-14 Major depressive disorder; LUSC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg11764359 chr7:65958608 NA -0.81 -13.56 -0.6 1.15e-33 Aortic root size; LUSC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg20744362 chr22:50050164 C22orf34 0.4 8.33 0.41 2.15e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9296092 0.538 rs62405948 chr6:33522753 A/C cg13560919 chr6:33536144 NA -0.82 -15.86 -0.66 1.26e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15157791 chr20:2854198 PTPRA 0.69 5.97 0.31 6.11e-9 Cognitive performance; LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg23758822 chr17:41437982 NA 1.06 20.2 0.74 7.16e-60 Menopause (age at onset); LUSC cis rs7923609 1.000 rs4400684 chr10:65012687 A/G cg01631684 chr10:65280961 REEP3 -0.42 -6.55 -0.34 2.14e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg18604133 chr13:27746144 USP12 -0.4 -6.75 -0.35 6.71e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs8028313 0.630 rs12900208 chr15:67963058 C/G cg24579218 chr15:68104479 NA -0.37 -6.13 -0.32 2.48e-9 Obesity; LUSC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg02034447 chr16:89574710 SPG7 0.44 6.48 0.33 3.2e-10 Multiple myeloma (IgH translocation); LUSC cis rs1538970 0.816 rs61788356 chr1:46006675 C/T cg05343316 chr1:45956843 TESK2 0.72 9.69 0.47 1.01e-19 Platelet count; LUSC cis rs11190604 1.000 rs2495753 chr10:102325640 C/T cg07080220 chr10:102295463 HIF1AN 0.7 8.39 0.42 1.39e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg09455208 chr3:40491958 NA -0.57 -10.52 -0.5 1.56e-22 Renal cell carcinoma; LUSC cis rs4619890 0.528 rs17770213 chr4:7896866 C/T cg24250820 chr4:7887609 AFAP1 -0.37 -6.35 -0.33 6.89e-10 Glaucoma (primary open-angle); LUSC trans rs208520 0.690 rs10455594 chr6:66737894 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.82 0.68 2.11e-46 Exhaled nitric oxide output; LUSC trans rs61931739 1.000 rs61931739 chr12:34089973 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.07 -0.32 3.52e-9 Morning vs. evening chronotype; LUSC trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.51 -7.09 -0.36 8.23e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9326248 0.954 rs8521 chr11:117067699 C/T cg11861562 chr11:117069780 TAGLN 0.44 7.81 0.39 7.71e-14 Blood protein levels; LUSC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg15445000 chr17:37608096 MED1 0.39 6.71 0.34 8.49e-11 Glomerular filtration rate (creatinine); LUSC cis rs3859192 0.539 rs2302774 chr17:38183090 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.59 0.57 5.27e-30 White blood cell count; LUSC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg26769984 chr7:1090371 C7orf50 0.69 9.75 0.47 6.11e-20 Bronchopulmonary dysplasia; LUSC cis rs8078723 0.901 rs709591 chr17:38175561 T/A cg17467752 chr17:38218738 THRA 0.77 12.42 0.56 2.3e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs8044868 0.586 rs6499557 chr16:72082654 A/G cg16579770 chr16:72058938 DHODH 0.34 5.76 0.3 1.95e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs3741404 0.609 rs687581 chr11:63871533 G/T cg18225595 chr11:63971243 STIP1 -0.41 -6.57 -0.34 1.97e-10 Platelet count; LUSC cis rs9611565 0.918 rs4820438 chr22:41767135 C/T cg03806693 chr22:41940476 POLR3H -0.84 -12.38 -0.56 3.13e-29 Vitiligo; LUSC cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.87 0.31 1.04e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs983392 0.651 rs718376 chr11:60002935 C/T cg02771260 chr11:59836817 MS4A3 -0.35 -5.68 -0.3 2.86e-8 Alzheimer's disease (late onset); LUSC cis rs1371867 0.817 rs1660315 chr8:101332956 G/A cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs9733 0.744 rs12758227 chr1:150844583 C/A cg04414720 chr1:150670196 GOLPH3L -0.45 -6.97 -0.36 1.75e-11 Tonsillectomy; LUSC trans rs6076960 0.652 rs3852945 chr20:6254118 T/C cg17788362 chr6:86352627 SYNCRIP 0.46 7.02 0.36 1.22e-11 Smooth-surface caries; LUSC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg17143192 chr8:8559678 CLDN23 0.36 5.8 0.3 1.56e-8 Mood instability; LUSC cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg13319975 chr6:146136371 FBXO30 0.49 7.47 0.38 6.96e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg13395646 chr4:1353034 KIAA1530 -0.58 -8.28 -0.41 2.95e-15 Longevity; LUSC cis rs12824058 0.707 rs2398509 chr12:130816464 T/C cg26677194 chr12:130822605 PIWIL1 0.59 8.31 0.41 2.52e-15 Menopause (age at onset); LUSC cis rs4363385 0.620 rs4388644 chr1:152983674 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.69 -0.39 1.71e-13 Inflammatory skin disease; LUSC cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg13010199 chr12:38710504 ALG10B 0.66 9.93 0.48 1.57e-20 Bladder cancer; LUSC cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.65 0.86 4.24e-99 Chronic sinus infection; LUSC cis rs2204008 0.630 rs1283300 chr12:38150227 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.2 -0.49 1.88e-21 Bladder cancer; LUSC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg24733560 chr20:60626293 TAF4 -0.39 -6.24 -0.32 1.36e-9 Body mass index; LUSC trans rs12188164 0.965 rs72717430 chr5:444502 T/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg13175981 chr1:150552382 MCL1 0.43 5.98 0.31 5.82e-9 Tonsillectomy; LUSC cis rs7193541 0.684 rs8062783 chr16:74691264 C/T cg01733217 chr16:74700730 RFWD3 -0.97 -21.94 -0.77 1.1e-66 Multiple myeloma; LUSC cis rs1018836 0.668 rs9297857 chr8:91480964 A/C cg16814680 chr8:91681699 NA -0.65 -9.61 -0.47 1.79e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs611744 0.647 rs864166 chr8:109249300 C/G cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 7.89e-10 Dupuytren's disease; LUSC cis rs11031096 0.714 rs3794049 chr11:4145658 A/G cg18678763 chr11:4115507 RRM1 0.38 5.77 0.3 1.79e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4820539 0.966 rs5996470 chr22:23483255 G/A cg21100191 chr22:23484243 RTDR1 0.93 16.53 0.67 2.82e-45 Bone mineral density; LUSC cis rs7020830 0.931 rs13288178 chr9:37107799 A/G cg14294708 chr9:37120828 ZCCHC7 1.1 23.27 0.79 7.21e-72 Schizophrenia; LUSC cis rs10186029 0.623 rs10497996 chr2:213997865 T/C cg08319019 chr2:214017104 IKZF2 0.52 7.9 0.4 4.21e-14 Systemic sclerosis; LUSC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs977987 0.836 rs35209155 chr16:75470496 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.11 -0.36 7.07e-12 Dupuytren's disease; LUSC cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.49 0.38 6.3e-13 Rheumatoid arthritis; LUSC cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg18477163 chr1:228402036 OBSCN -0.57 -10.45 -0.5 2.61e-22 Diastolic blood pressure; LUSC cis rs1107366 1.000 rs1107366 chr3:125904165 A/G cg01346077 chr3:125931526 NA 0.35 6.7 0.34 8.75e-11 Metabolite levels; LUSC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg17971929 chr21:40555470 PSMG1 -0.51 -7.63 -0.39 2.48e-13 Menarche (age at onset); LUSC trans rs877282 1.000 rs877281 chr10:771557 T/G cg22713356 chr15:30763199 NA 1.1 15.11 0.64 1.09e-39 Uric acid levels; LUSC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.57 0.34 1.88e-10 Intelligence (multi-trait analysis); LUSC cis rs8017423 0.935 rs3742667 chr14:90767856 T/C cg04374321 chr14:90722782 PSMC1 -0.68 -10.24 -0.49 1.39e-21 Mortality in heart failure; LUSC cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg03517284 chr6:25882590 NA -0.52 -9.66 -0.47 1.25e-19 Blood metabolite levels; LUSC cis rs9300255 0.739 rs4759417 chr12:123746510 C/T cg00376283 chr12:123451042 ABCB9 0.66 8.34 0.42 2e-15 Neutrophil percentage of white cells; LUSC cis rs2439831 0.850 rs544122 chr15:43775732 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.98 11.02 0.52 2.65e-24 Lung cancer in ever smokers; LUSC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg06544989 chr22:39130855 UNC84B 0.34 5.91 0.31 8.33e-9 Menopause (age at onset); LUSC cis rs9796 0.870 rs2412572 chr15:41264426 G/C cg18705301 chr15:41695430 NDUFAF1 0.44 7.74 0.39 1.2e-13 Menopause (age at onset); LUSC trans rs62344088 1.000 rs13436694 chr5:122882 A/T cg11454300 chr2:2256402 MYT1L 0.75 6.03 0.31 4.27e-9 Asthma (childhood onset); LUSC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg22875332 chr1:76189707 ACADM 0.85 14.08 0.61 1.16e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs939658 0.728 rs12904323 chr15:79412583 A/C cg17916960 chr15:79447300 NA -0.49 -9.13 -0.45 6.73e-18 Refractive error; LUSC cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs17401966 0.838 rs12127604 chr1:10352800 T/G cg19773385 chr1:10388646 KIF1B -0.5 -8.66 -0.43 2.11e-16 Hepatocellular carcinoma; LUSC trans rs3942852 0.868 rs7118226 chr11:48106267 T/G cg15704280 chr7:45808275 SEPT13 -0.55 -6.28 -0.32 1.03e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs9326248 0.581 rs6589590 chr11:116936081 A/C cg20608306 chr11:116969690 SIK3 0.37 6.8 0.35 4.86e-11 Blood protein levels; LUSC cis rs11190604 1.000 rs1054399 chr10:102312565 C/T cg16342193 chr10:102329863 NA -0.34 -6.03 -0.31 4.38e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg05776053 chr2:74358815 NA 0.45 7.22 0.37 3.62e-12 Gestational age at birth (maternal effect); LUSC cis rs30380 0.506 rs469735 chr5:96130014 T/C cg16492584 chr5:96139282 ERAP1 -0.53 -7.18 -0.37 4.44e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg22166914 chr1:53195759 ZYG11B 0.71 12.07 0.55 4.43e-28 Monocyte count; LUSC cis rs28795989 0.795 rs4696778 chr4:7919308 C/G cg00251875 chr4:7801337 AFAP1 -0.43 -6.42 -0.33 4.6e-10 Intraocular pressure; LUSC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg19046167 chr17:80928561 B3GNTL1 0.45 6.81 0.35 4.52e-11 Breast cancer; LUSC cis rs7119038 0.865 rs4938573 chr11:118741842 C/T cg19308663 chr11:118741387 NA -0.34 -5.75 -0.3 2.02e-8 Sjögren's syndrome; LUSC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg06212747 chr3:49208901 KLHDC8B 0.45 5.84 0.3 1.25e-8 Parkinson's disease; LUSC cis rs10170846 0.800 rs10180462 chr2:223526385 C/T cg25565276 chr2:223520875 FARSB 0.64 9.7 0.47 9.46e-20 Schizophrenia (inflammation and infection response interaction); LUSC cis rs2742234 0.541 rs61268333 chr10:43721370 G/A cg15436174 chr10:43711423 RASGEF1A 0.44 7.06 0.36 9.75e-12 Hirschsprung disease; LUSC cis rs7264396 0.561 rs6060741 chr20:34571484 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.73 0.35 7.44e-11 Total cholesterol levels; LUSC trans rs10506458 0.915 rs60094497 chr12:63394838 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -15.44 -0.65 5.73e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg05890377 chr2:74357713 NA 0.72 13.82 0.6 1.11e-34 Gestational age at birth (maternal effect); LUSC cis rs9303401 0.659 rs34351230 chr17:56782555 C/A cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs9811920 0.809 rs13059754 chr3:99678490 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.57 -0.34 1.9e-10 Axial length; LUSC cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg24250549 chr1:154909240 PMVK 0.64 10.43 0.5 3.19e-22 Prostate cancer; LUSC cis rs9303280 0.901 rs8067378 chr17:38051348 A/G cg20243544 chr17:37824526 PNMT 0.4 6.01 0.31 4.94e-9 Self-reported allergy; LUSC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg11062466 chr8:58055876 NA 0.43 5.79 0.3 1.63e-8 Developmental language disorder (linguistic errors); LUSC cis rs2742540 0.503 rs7106539 chr11:8897533 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.36 -6.36 -0.33 6.78e-10 Hematocrit; LUSC cis rs12682352 0.602 rs28399241 chr8:8663215 C/T cg15556689 chr8:8085844 FLJ10661 0.57 8.2 0.41 5.1e-15 Neuroticism; LUSC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg26958806 chr6:27640298 NA 0.68 5.75 0.3 2.02e-8 Depression; LUSC cis rs9467773 1.000 rs6456733 chr6:26566804 C/T cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs6835098 0.961 rs28709762 chr4:174099149 T/C cg08422745 chr4:174089978 GALNT7 -0.82 -13.33 -0.59 8.19e-33 Dementia and core Alzheimer's disease neuropathologic changes; LUSC trans rs74417235 0.610 rs13178134 chr5:154063032 A/T cg13111374 chr4:17812581 NCAPG;DCAF16 -0.57 -5.96 -0.31 6.3e-9 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; LUSC cis rs754466 0.510 rs55893027 chr10:79588209 C/T cg17075019 chr10:79541650 NA -0.65 -10.15 -0.49 2.87e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC cis rs9308433 0.733 rs11120300 chr1:214509499 A/T cg06198575 chr1:214491504 SMYD2 -0.4 -6.44 -0.33 4.15e-10 IgG glycosylation; LUSC cis rs10484885 0.878 rs72921959 chr6:90591326 C/G cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.37 -0.42 1.58e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10883723 0.962 rs1056741 chr10:104236640 A/C cg22532475 chr10:104410764 TRIM8 -0.35 -7.6 -0.38 2.92e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg14416269 chr4:6271139 WFS1 -0.47 -9.13 -0.45 6.7e-18 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs62283056 0.512 rs752854 chr4:6281961 C/T cg25554036 chr4:6271136 WFS1 0.51 9.11 0.45 7.51e-18 Cisplatin-induced ototoxicity; LUSC trans rs72674100 0.737 rs28461925 chr4:97991609 G/T cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs7769051 1.000 rs9493445 chr6:133125409 C/T cg27275811 chr11:74457193 NA -0.64 -6.22 -0.32 1.51e-9 Type 2 diabetes nephropathy; LUSC cis rs4713675 0.584 rs6916949 chr6:33678290 C/G cg14003231 chr6:33640908 ITPR3 0.29 5.69 0.3 2.82e-8 Plateletcrit; LUSC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11644478 chr21:40555479 PSMG1 0.94 18.4 0.71 1.07e-52 Cognitive function; LUSC cis rs7829975 0.846 rs11779061 chr8:8549432 G/A cg18904891 chr8:8559673 CLDN23 -0.38 -5.71 -0.3 2.5e-8 Mood instability; LUSC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.16 15.87 0.66 1.16e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs35079168 0.923 rs10858276 chr9:137287913 C/T cg13941235 chr9:137270186 RXRA -0.33 -5.75 -0.3 2.03e-8 Intelligence; LUSC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg19230755 chr7:65878503 NA 0.43 6.1 0.32 2.96e-9 Aortic root size; LUSC cis rs1348850 0.526 rs4893829 chr2:178399810 A/G cg22681709 chr2:178499509 PDE11A 0.43 6.27 0.32 1.13e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg10523860 chr14:103875565 MARK3 -0.37 -5.9 -0.31 9.07e-9 Body mass index; LUSC cis rs16976116 0.855 rs7172289 chr15:55501705 A/G cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2046867 0.862 rs6805234 chr3:72829869 A/G cg25664220 chr3:72788482 NA -0.67 -12.43 -0.56 2.05e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg22782873 chr19:19639568 YJEFN3 -0.48 -6.11 -0.32 2.7e-9 Bipolar disorder; LUSC cis rs9837602 1.000 rs2291495 chr3:99782227 T/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.16 0.32 2.03e-9 Breast cancer; LUSC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg12463550 chr7:65579703 CRCP -0.43 -6.36 -0.33 6.61e-10 Aortic root size; LUSC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg18196295 chr10:418757 DIP2C -0.48 -7.95 -0.4 2.81e-14 Psychosis in Alzheimer's disease; LUSC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.82 12.4 0.56 2.57e-29 Cognitive test performance; LUSC cis rs2832077 0.506 rs10222093 chr21:30163518 T/C cg24692254 chr21:30365293 RNF160 -0.54 -7.19 -0.37 4.39e-12 Cognitive test performance; LUSC cis rs4631830 0.695 rs11004584 chr10:51500088 G/T cg20129853 chr10:51489980 NA -0.37 -7.65 -0.39 2.13e-13 Prostate-specific antigen levels; LUSC cis rs7980687 0.657 rs10744151 chr12:123723735 G/C cg05973401 chr12:123451056 ABCB9 0.52 7.09 0.36 7.87e-12 Height;Educational attainment;Head circumference (infant); LUSC cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg23711669 chr6:146136114 FBXO30 -0.83 -14.9 -0.63 7.35e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs9837602 1.000 rs9851645 chr3:99767409 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.17 0.32 1.98e-9 Breast cancer; LUSC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg00316803 chr15:76480434 C15orf27 -0.4 -6.93 -0.35 2.11e-11 Blood metabolite levels; LUSC trans rs853679 0.546 rs71537572 chr6:27970715 T/C cg06606381 chr12:133084897 FBRSL1 -0.95 -8.71 -0.43 1.43e-16 Depression; LUSC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg06287003 chr12:125626642 AACS 0.37 5.92 0.31 7.89e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.72 -0.35 7.72e-11 Crohn's disease; LUSC cis rs4499344 0.657 rs259238 chr19:33140381 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.78 11.49 0.53 5.77e-26 Mean platelet volume; LUSC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg00745463 chr17:30367425 LRRC37B -0.7 -8.63 -0.43 2.59e-16 Hip circumference adjusted for BMI; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06211272 chr1:59012675 OMA1 -0.45 -6.62 -0.34 1.41e-10 Electrocardiographic conduction measures; LUSC trans rs9291683 0.692 rs1558489 chr4:10325489 T/A cg26043149 chr18:55253948 FECH -0.54 -8.25 -0.41 3.75e-15 Bone mineral density; LUSC cis rs11098499 0.954 rs6848389 chr4:120402622 A/G cg09307838 chr4:120376055 NA 0.76 11.44 0.53 8.56e-26 Corneal astigmatism; LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg11494091 chr17:61959527 GH2 0.64 13.34 0.59 7.84e-33 Prudent dietary pattern; LUSC cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.59 0.43 3.46e-16 Menopause (age at onset); LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg26354017 chr1:205819088 PM20D1 0.47 6.82 0.35 4.41e-11 Prostate-specific antigen levels; LUSC cis rs1448094 1.000 rs7305284 chr12:86343786 C/T cg18827107 chr12:86230957 RASSF9 -0.41 -6.29 -0.33 1e-9 Major depressive disorder; LUSC cis rs2639990 0.744 rs640261 chr18:72905808 C/T cg18449964 chr18:72917101 ZADH2 0.48 5.72 0.3 2.31e-8 Vascular endothelial growth factor levels; LUSC cis rs11098499 0.865 rs10213221 chr4:120255926 G/A cg24375607 chr4:120327624 NA 0.77 12.5 0.56 1.08e-29 Corneal astigmatism; LUSC cis rs9487051 0.839 rs13196590 chr6:109561918 T/C cg01475377 chr6:109611718 NA -0.36 -5.83 -0.3 1.28e-8 Reticulocyte fraction of red cells; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg10360139 chr7:1886902 MAD1L1 -0.45 -6.95 -0.36 1.89e-11 Bipolar disorder and schizophrenia; LUSC cis rs57244997 0.932 rs73026582 chr6:162406460 C/T cg17173639 chr6:162384350 PARK2 -0.59 -6.02 -0.31 4.68e-9 Mosquito bite size; LUSC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.55 7.16 0.36 5.03e-12 Multiple sclerosis; LUSC cis rs459571 0.959 rs2520100 chr9:136918137 A/T cg13789015 chr9:136890014 NCRNA00094 0.7 13.04 0.58 1.07e-31 Platelet distribution width; LUSC trans rs61931739 0.500 rs11053201 chr12:34453903 T/A cg13010199 chr12:38710504 ALG10B 0.68 10.81 0.51 1.49e-23 Morning vs. evening chronotype; LUSC cis rs17401966 0.931 rs3748579 chr1:10420937 C/T cg19773385 chr1:10388646 KIF1B -0.57 -9.86 -0.47 2.77e-20 Hepatocellular carcinoma; LUSC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 7.93 0.4 3.33e-14 Personality dimensions; LUSC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.54 0.46 3.08e-19 Mean platelet volume; LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1997103 1.000 rs6973450 chr7:55396537 A/G cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9814567 0.752 rs7649910 chr3:134241310 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.71 -0.6 2.98e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs250677 0.687 rs250679 chr5:148434952 A/T cg23229984 chr5:148520753 ABLIM3 -0.36 -6.21 -0.32 1.54e-9 Breast cancer; LUSC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg18876405 chr7:65276391 NA 0.51 7.93 0.4 3.3e-14 Aortic root size; LUSC cis rs6599077 0.950 rs4676560 chr3:40097649 G/C cg13683864 chr3:40499215 RPL14 -0.6 -7.36 -0.37 1.4e-12 Sleep-related phenotypes; LUSC cis rs9326248 0.581 rs7106437 chr11:116992076 T/C cg26566898 chr11:117069891 TAGLN 0.38 7.43 0.38 8.95e-13 Blood protein levels; LUSC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg14004847 chr7:1930337 MAD1L1 -0.57 -8.49 -0.42 6.73e-16 Schizophrenia; LUSC cis rs10752881 0.935 rs10911197 chr1:182995399 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.05 0.52 2.14e-24 Colorectal cancer; LUSC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg24250549 chr1:154909240 PMVK 0.66 11.05 0.52 2.07e-24 Prostate cancer; LUSC cis rs7336332 0.598 rs74563672 chr13:28010660 A/G cg22138327 chr13:27999177 GTF3A 0.8 10.02 0.48 7.6e-21 Weight; LUSC cis rs2742417 0.967 rs1969625 chr3:45734975 A/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.38 -0.37 1.24e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg22875332 chr1:76189707 ACADM 0.84 15.56 0.65 1.93e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.62e-10 Developmental language disorder (linguistic errors); LUSC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg12403142 chr1:92012408 NA -0.38 -6.03 -0.31 4.31e-9 Breast cancer; LUSC cis rs709400 0.628 rs2010281 chr14:103862322 G/A cg10523860 chr14:103875565 MARK3 -0.4 -6.44 -0.33 4.18e-10 Body mass index; LUSC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg09044154 chr16:88155775 NA -0.56 -7.56 -0.38 3.96e-13 Menopause (age at onset); LUSC cis rs1865760 0.686 rs12210098 chr6:25963966 C/T cg17691542 chr6:26056736 HIST1H1C 0.59 8.36 0.42 1.77e-15 Height; LUSC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.6 0.46 2.01e-19 Mean platelet volume; LUSC trans rs2797501 0.615 rs2797491 chr10:5788608 C/G cg27513495 chr1:11714724 FBXO2;FBXO44 0.53 6.0 0.31 5.04e-9 Osteosarcoma; LUSC cis rs1728785 0.901 rs1183956 chr16:68606726 G/A cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC trans rs2392780 0.536 rs34628978 chr8:128336744 G/A cg10897648 chr18:56338258 MALT1 -0.42 -6.24 -0.32 1.33e-9 Breast cancer (early onset); LUSC cis rs7267979 1.000 rs6132835 chr20:25434667 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.65 0.75 1.23e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg14019146 chr3:50243930 SLC38A3 0.37 8.43 0.42 1.04e-15 Body mass index; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg17178900 chr1:205818956 PM20D1 0.74 13.07 0.58 8.16e-32 Monocyte percentage of white cells; LUSC cis rs7818345 0.935 rs4633071 chr8:19275852 G/A cg11303988 chr8:19266685 CSGALNACT1 0.36 6.92 0.35 2.31e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg00310523 chr12:86230176 RASSF9 0.45 7.99 0.4 2.18e-14 Major depressive disorder; LUSC cis rs2594989 0.836 rs347607 chr3:11268021 A/C cg00170343 chr3:11313890 ATG7 -0.52 -5.97 -0.31 6.05e-9 Circulating chemerin levels; LUSC cis rs12421382 0.659 rs1837396 chr11:109389257 G/A cg11473876 chr11:109292803 C11orf87 0.35 5.97 0.31 5.95e-9 Schizophrenia; LUSC cis rs17270561 0.609 rs1937132 chr6:25757017 A/G cg16482183 chr6:26056742 HIST1H1C 0.65 9.0 0.44 1.7e-17 Iron status biomarkers; LUSC cis rs3813567 0.759 rs12595350 chr15:78953464 G/A cg24631222 chr15:78858424 CHRNA5 0.58 6.4 0.33 5.37e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2573652 0.722 rs12904962 chr15:100544113 A/G cg00587665 chr15:100533223 ADAMTS17 0.38 6.92 0.35 2.3e-11 Height; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.24 0.37 3.19e-12 Alzheimer's disease; LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg19346786 chr7:2764209 NA 0.49 8.55 0.42 4.62e-16 Height; LUSC cis rs12291225 0.679 rs11023172 chr11:14295367 C/G cg19336497 chr11:14380999 RRAS2 -0.57 -11.78 -0.54 5.12e-27 Sense of smell; LUSC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg24881330 chr22:46731750 TRMU 0.85 8.39 0.42 1.38e-15 LDL cholesterol;Cholesterol, total; LUSC trans rs1493916 0.905 rs9956315 chr18:31405546 G/C cg13755796 chr4:20253514 NA -0.42 -6.57 -0.34 1.95e-10 Life satisfaction; LUSC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.51 0.62 2.44e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7267979 0.816 rs3746337 chr20:25208272 C/T cg08601574 chr20:25228251 PYGB 0.55 8.78 0.43 8.87e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs656319 0.580 rs17690549 chr8:9998538 C/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.36 -0.33 6.74e-10 Myopia (pathological); LUSC cis rs9467773 0.596 rs2451751 chr6:26646714 T/C cg05738196 chr6:26577821 NA 0.78 14.89 0.63 7.91e-39 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.958 rs12191340 chr6:86521400 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.63 -0.34 1.37e-10 Response to antipsychotic treatment; LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.67e-9 Monocyte count; LUSC cis rs7647973 1.000 rs9862534 chr3:49598064 A/G cg07636037 chr3:49044803 WDR6 0.68 9.14 0.45 6.02e-18 Menarche (age at onset); LUSC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg23758822 chr17:41437982 NA 0.91 16.26 0.66 3.41e-44 Menopause (age at onset); LUSC cis rs3733631 1.000 rs10014175 chr4:104659515 T/A cg24090629 chr4:104641072 TACR3 -0.49 -5.99 -0.31 5.58e-9 Menarche (age at onset); LUSC cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg26536354 chr8:144654954 C8orf73 -0.46 -6.49 -0.33 3.16e-10 Attention deficit hyperactivity disorder; LUSC cis rs17401966 1.000 rs12117765 chr1:10268170 A/G cg19773385 chr1:10388646 KIF1B -0.52 -8.26 -0.41 3.34e-15 Hepatocellular carcinoma; LUSC cis rs6963495 0.745 rs73192150 chr7:105211610 A/C cg13798780 chr7:105162888 PUS7 0.56 5.83 0.3 1.28e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2762353 0.902 rs1165199 chr6:25809087 C/T cg03517284 chr6:25882590 NA -0.43 -7.77 -0.39 9.83e-14 Blood metabolite levels; LUSC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs7772486 0.875 rs2814871 chr6:146312274 G/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.85 -0.35 3.6e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9291683 0.588 rs11732054 chr4:9999877 C/T cg00071950 chr4:10020882 SLC2A9 0.66 11.18 0.52 7.3e-25 Bone mineral density; LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg24531977 chr5:56204891 C5orf35 -0.64 -9.53 -0.46 3.3e-19 Coronary artery disease; LUSC cis rs4494114 0.967 rs9438977 chr1:39354958 A/G cg25970120 chr1:39325951 RRAGC -0.39 -6.07 -0.32 3.44e-9 Blood protein levels; LUSC cis rs11608355 0.545 rs2302709 chr12:109893697 A/G cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs6460942 0.591 rs80311633 chr7:12339690 G/C cg06484146 chr7:12443880 VWDE -0.58 -6.15 -0.32 2.25e-9 Coronary artery disease; LUSC cis rs4595586 0.525 rs3914597 chr12:39388693 G/A cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs2274273 0.901 rs7147136 chr14:55826688 G/C cg04306507 chr14:55594613 LGALS3 0.54 11.97 0.55 1.05e-27 Protein biomarker; LUSC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg23982607 chr1:1823379 GNB1 -0.5 -8.98 -0.44 1.99e-17 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17212720 chr6:160148002 WTAP -0.45 -6.87 -0.35 3.1e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10761482 0.500 rs7072229 chr10:62284220 C/G cg18175470 chr10:62150864 ANK3 -0.51 -7.45 -0.38 8.19e-13 Schizophrenia; LUSC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg09796270 chr17:17721594 SREBF1 -0.41 -7.14 -0.36 5.86e-12 Total body bone mineral density; LUSC trans rs28647808 0.881 rs4246171 chr9:136264731 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs477692 0.875 rs7091540 chr10:131420276 C/T cg26102564 chr10:131424627 MGMT -0.36 -5.69 -0.3 2.74e-8 Response to temozolomide; LUSC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.33 0.62 1.18e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11997175 0.625 rs11777333 chr8:33596470 C/A ch.8.33884649F chr8:33765107 NA 0.42 6.66 0.34 1.15e-10 Body mass index; LUSC cis rs2625529 0.689 rs12898868 chr15:72112918 A/G cg16672083 chr15:72433130 SENP8 0.46 7.54 0.38 4.53e-13 Red blood cell count; LUSC cis rs427941 0.703 rs201454 chr7:101740056 A/G cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg24399712 chr22:39784796 NA -0.58 -9.32 -0.45 1.61e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg25036284 chr2:26402008 FAM59B 0.78 11.3 0.53 2.64e-25 Gut microbiome composition (summer); LUSC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11098499 0.863 rs6858592 chr4:120458692 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.68 0.34 9.93e-11 Corneal astigmatism; LUSC cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.79 0.3 1.64e-8 Rheumatoid arthritis; LUSC cis rs2290416 0.892 rs3829012 chr8:144664656 C/T cg14809332 chr8:144654887 C8orf73 0.52 6.47 0.33 3.57e-10 Attention deficit hyperactivity disorder; LUSC cis rs8077889 0.957 rs17742929 chr17:41891437 C/T cg26893861 chr17:41843967 DUSP3 0.92 13.2 0.59 2.63e-32 Triglycerides; LUSC cis rs259282 0.583 rs3760938 chr19:33106907 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.65 9.7 0.47 9.23e-20 Schizophrenia; LUSC cis rs10979 1.000 rs7774497 chr6:143889033 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs6700896 0.500 rs11208688 chr1:66081355 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs9929218 0.906 rs10852450 chr16:68749529 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -12.35 -0.56 4.23e-29 Colorectal cancer; LUSC trans rs2840044 1.000 rs11080357 chr17:33898933 G/A cg19694781 chr19:47549865 TMEM160 0.59 9.52 0.46 3.59e-19 Response to radiotherapy in cancer (late toxicity); LUSC trans rs12210905 1.000 rs76889265 chr6:27008835 T/C cg11837749 chr1:55047332 ACOT11 0.58 6.07 0.32 3.47e-9 Hip circumference adjusted for BMI; LUSC cis rs8141529 0.778 rs5762795 chr22:29182500 C/A cg02153584 chr22:29168773 CCDC117 0.66 10.29 0.49 9.61e-22 Lymphocyte counts; LUSC cis rs10266483 0.515 rs6948710 chr7:63866003 G/A cg24201672 chr7:64023550 ZNF680 0.5 6.14 0.32 2.39e-9 Response to statin therapy; LUSC cis rs7215564 0.818 rs1032130 chr17:78610636 A/G cg09596252 chr17:78655493 RPTOR -0.56 -6.27 -0.32 1.1e-9 Myopia (pathological); LUSC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg06481639 chr22:41940642 POLR3H -0.54 -6.42 -0.33 4.64e-10 Vitiligo; LUSC cis rs8038465 1.000 rs8041523 chr15:73982556 C/T cg15420318 chr15:73925796 NPTN 0.39 6.14 0.32 2.34e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10465746 0.967 rs11163861 chr1:84354282 T/C cg10977910 chr1:84465055 TTLL7 0.44 6.35 0.33 6.92e-10 Obesity-related traits; LUSC cis rs372883 0.624 rs1153286 chr21:30684383 A/G cg24692254 chr21:30365293 RNF160 -0.68 -10.51 -0.5 1.58e-22 Pancreatic cancer; LUSC cis rs10489202 0.633 rs4657734 chr1:168086743 C/T cg24449463 chr1:168025552 DCAF6 -0.65 -9.97 -0.48 1.12e-20 Schizophrenia; LUSC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg03929089 chr4:120376271 NA 0.6 6.53 0.34 2.43e-10 Axial length; LUSC cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg19875535 chr5:140030758 IK 0.47 7.54 0.38 4.59e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs9311676 0.656 rs7647078 chr3:58369912 C/T cg13750441 chr3:58318267 PXK 0.35 6.7 0.34 8.72e-11 Systemic lupus erythematosus; LUSC trans rs9908158 1 rs9908158 chr17:33890083 T/C cg19694781 chr19:47549865 TMEM160 0.58 9.28 0.45 2.14e-18 Platelet count;Platelet distribution width; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.29 -0.49 9.15e-22 Bipolar disorder; LUSC cis rs7129556 0.520 rs12290511 chr11:77266663 T/G cg12586386 chr11:77299805 AQP11 0.23 5.79 0.3 1.66e-8 Weight loss (gastric bypass surgery); LUSC cis rs2249625 0.545 rs2496505 chr6:72891063 C/G cg18830697 chr6:72922368 RIMS1 -0.36 -7.37 -0.37 1.34e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg07212818 chr11:638076 DRD4 -0.42 -7.15 -0.36 5.65e-12 Systemic lupus erythematosus; LUSC cis rs12579753 0.917 rs7954438 chr12:82184419 T/C cg21231944 chr12:82153410 PPFIA2 -0.37 -5.68 -0.3 2.88e-8 Resting heart rate; LUSC cis rs1801251 0.778 rs709933 chr2:233733144 G/A cg08000102 chr2:233561755 GIGYF2 -0.51 -7.96 -0.4 2.79e-14 Coronary artery disease; LUSC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC cis rs7809950 1.000 rs10251808 chr7:107120453 G/A cg23024343 chr7:107201750 COG5 -0.55 -8.83 -0.43 6.08e-17 Coronary artery disease; LUSC cis rs34779708 0.931 rs7908573 chr10:35309513 T/C cg03585969 chr10:35415529 CREM 0.6 8.67 0.43 1.86e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg22834771 chr12:69754056 YEATS4 -0.5 -7.45 -0.38 8.09e-13 Blood protein levels; LUSC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg15448220 chr1:150897856 SETDB1 0.41 5.92 0.31 8.13e-9 Melanoma; LUSC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg19468946 chr17:37922297 IKZF3 -0.42 -6.57 -0.34 1.88e-10 Self-reported allergy; LUSC cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg12165864 chr7:66369176 NA -0.53 -7.07 -0.36 8.93e-12 Corneal structure; LUSC cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg06552810 chr11:31128660 NA -0.42 -7.41 -0.38 1.05e-12 Red blood cell count; LUSC cis rs6987853 0.901 rs2974344 chr8:42400732 T/G cg09913449 chr8:42400586 C8orf40 0.49 8.24 0.41 4.06e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.54 8.24 0.41 3.85e-15 Lymphocyte counts; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg08888203 chr3:10149979 C3orf24 0.6 8.27 0.41 3.2e-15 Alzheimer's disease; LUSC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg03264133 chr6:25882463 NA -0.47 -7.94 -0.4 3.02e-14 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg20887711 chr4:1340912 KIAA1530 0.39 5.77 0.3 1.78e-8 Obesity-related traits; LUSC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.44 -0.33 4.08e-10 Alzheimer's disease (late onset); LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg04141948 chr7:1023156 CYP2W1 0.28 5.91 0.31 8.49e-9 Longevity;Endometriosis; LUSC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg05347473 chr6:146136440 FBXO30 0.44 7.48 0.38 6.41e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1368882 0.814 rs1702020 chr1:55105728 C/T cg01517571 chr1:55089959 ACOT11;FAM151A 0.51 8.12 0.41 9.23e-15 Non-substance related behavioral disinhibition; LUSC cis rs7927592 0.913 rs6591340 chr11:68297636 A/G cg20283391 chr11:68216788 NA -0.61 -8.55 -0.42 4.43e-16 Total body bone mineral density; LUSC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg07389463 chr12:132296394 NA 0.39 7.24 0.37 3.13e-12 Migraine; LUSC cis rs3733418 0.929 rs4690797 chr4:165908505 G/C cg08992305 chr4:165878219 TRIM61;C4orf39 -0.51 -5.92 -0.31 8.03e-9 Obesity-related traits; LUSC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg22467129 chr15:76604101 ETFA -0.45 -7.15 -0.36 5.63e-12 Blood metabolite levels; LUSC cis rs2050392 0.517 rs589980 chr10:30756385 T/A cg25182066 chr10:30743637 MAP3K8 -0.46 -6.86 -0.35 3.44e-11 Inflammatory bowel disease; LUSC cis rs12594515 0.967 rs11070465 chr15:45984899 A/G cg06207120 chr15:45996521 NA 0.4 6.14 0.32 2.33e-9 Waist circumference;Weight; LUSC cis rs11190604 1.000 rs2495760 chr10:102318771 T/C cg07080220 chr10:102295463 HIF1AN 0.69 8.35 0.42 1.82e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs78545713 0.649 rs11757549 chr6:26231608 G/A cg23601095 chr6:26197514 HIST1H3D 0.64 5.76 0.3 1.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs8072100 0.720 rs4794057 chr17:45786452 C/T cg08085267 chr17:45401833 C17orf57 -0.5 -7.83 -0.39 6.37e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs4665809 0.941 rs2289021 chr2:26362515 A/C cg19249749 chr1:223853145 CAPN8 0.49 6.47 0.33 3.49e-10 Gut microbiome composition (summer); LUSC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.69 -0.39 1.67e-13 Blood metabolite levels; LUSC trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg15556689 chr8:8085844 FLJ10661 -0.5 -7.75 -0.39 1.13e-13 Neuroticism; LUSC cis rs12190007 0.573 rs13202383 chr6:169826544 A/G cg15038512 chr6:170123185 PHF10 -0.39 -6.32 -0.33 8.58e-10 Obesity-related traits; LUSC cis rs73198271 0.740 rs10113326 chr8:8647630 A/T cg15556689 chr8:8085844 FLJ10661 -0.47 -6.2 -0.32 1.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg09877947 chr5:131593287 PDLIM4 0.45 7.06 0.36 9.41e-12 Breast cancer; LUSC trans rs459571 0.920 rs455073 chr9:136909141 G/C cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.43 -6.13 -0.32 2.47e-9 Platelet distribution width; LUSC cis rs3925075 1.000 rs9673405 chr16:31347599 A/C cg02846316 chr16:31340340 ITGAM 0.36 6.66 0.34 1.11e-10 IgA nephropathy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11808854 chr20:60697627 LSM14B -0.45 -6.29 -0.33 1e-9 Bipolar disorder and schizophrenia; LUSC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg03526776 chr6:41159608 TREML2 -0.48 -9.28 -0.45 2.27e-18 Alzheimer's disease (late onset); LUSC cis rs6961069 0.527 rs997906 chr7:80279835 A/T cg04458919 chr7:80252533 CD36 -0.39 -6.63 -0.34 1.36e-10 Platelet count; LUSC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18404041 chr3:52824283 ITIH1 -0.54 -10.45 -0.5 2.62e-22 Bipolar disorder; LUSC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg26597838 chr10:835615 NA 1.21 16.6 0.67 1.46e-45 Eosinophil percentage of granulocytes; LUSC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg06718696 chr17:78121285 EIF4A3 0.44 6.23 0.32 1.37e-9 Yeast infection; LUSC cis rs6977660 0.714 rs10249635 chr7:19787090 A/G cg05791153 chr7:19748676 TWISTNB 0.76 7.46 0.38 7.38e-13 Thyroid stimulating hormone; LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.818 rs407448 chr1:153007504 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.91 -0.4 3.76e-14 Inflammatory skin disease; LUSC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.65 0.57 3.13e-30 Cognitive test performance; LUSC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC cis rs6582630 0.679 rs7301806 chr12:38596667 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.84 0.44 5.5e-17 Drug-induced liver injury (flucloxacillin); LUSC cis rs10979 1.000 rs9403506 chr6:143887805 C/G cg25407410 chr6:143891975 LOC285740 -0.73 -11.85 -0.54 2.71e-27 Hypospadias; LUSC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg27432699 chr2:27873401 GPN1 -0.57 -8.4 -0.42 1.27e-15 Total body bone mineral density; LUSC trans rs6982636 0.744 rs2954021 chr8:126482077 A/G cg13325919 chr3:181432053 SOX2;SOX2OT -0.33 -6.35 -0.33 6.9e-10 Lipid metabolism phenotypes; LUSC cis rs9309473 0.528 rs11126396 chr2:73565143 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.87 -0.35 3.12e-11 Metabolite levels; LUSC cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.42 -0.38 9.65e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs7149337 0.837 rs4296182 chr14:51662167 A/C cg23942311 chr14:51606299 NA 0.45 9.72 0.47 7.72e-20 Cancer; LUSC cis rs1577917 0.958 rs13213899 chr6:86473140 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.12 -0.36 6.84e-12 Response to antipsychotic treatment; LUSC trans rs62238980 0.614 rs115866486 chr22:32510228 A/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -6.12 -0.32 2.69e-9 Childhood ear infection; LUSC cis rs1113500 1.000 rs1113500 chr1:108595442 G/T cg11967332 chr1:108735228 SLC25A24 -0.38 -5.65 -0.3 3.42e-8 Growth-regulated protein alpha levels; LUSC cis rs2652834 0.808 rs2652789 chr15:63415223 A/C cg05507819 chr15:63340323 TPM1 0.45 5.82 0.3 1.37e-8 HDL cholesterol; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg24419099 chr11:47270565 NR1H3;ACP2 0.43 6.49 0.33 3.17e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg04267008 chr7:1944627 MAD1L1 -0.67 -10.33 -0.49 6.83e-22 Bipolar disorder and schizophrenia; LUSC cis rs354225 0.544 rs10208219 chr2:54806047 G/A cg01766943 chr2:54829624 SPTBN1 0.48 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg16228356 chr17:43848958 NA -0.27 -6.1 -0.32 2.89e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9650657 0.707 rs7814757 chr8:10675188 T/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.24 -0.32 1.3e-9 Neuroticism; LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg21724239 chr8:58056113 NA 0.78 9.78 0.47 5.05e-20 Developmental language disorder (linguistic errors); LUSC trans rs2587949 0.593 rs2600135 chr3:4209896 C/T cg15139668 chr4:4577005 NA -0.41 -6.03 -0.31 4.44e-9 Periodontitis (DPAL); LUSC cis rs10744422 1.000 rs2292135 chr12:123334075 G/A cg25930673 chr12:123319894 HIP1R -0.72 -7.2 -0.37 4.13e-12 Schizophrenia; LUSC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg10411590 chr13:21900810 NA 0.29 5.75 0.3 2e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20143895 chr1:247095226 AHCTF1 0.48 6.55 0.34 2.16e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg06221963 chr1:154839813 KCNN3 -0.59 -12.97 -0.58 2.03e-31 Prostate cancer; LUSC cis rs1371867 0.846 rs1616833 chr8:101271821 C/T cg06002616 chr8:101225028 SPAG1 0.39 6.57 0.34 1.97e-10 Atrioventricular conduction; LUSC cis rs4074961 0.669 rs6687545 chr1:38071195 C/T cg02930200 chr1:38022384 DNALI1 0.28 5.78 0.3 1.68e-8 Axial length; LUSC cis rs7904368 0.951 rs7074647 chr10:16855455 T/C cg23933602 chr10:16859644 RSU1 0.62 8.08 0.4 1.2e-14 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs4776059 1.000 rs4776065 chr15:52929716 A/G cg22715398 chr15:52968154 KIAA1370 0.64 9.39 0.46 9.85e-19 Schizophrenia; LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg13047869 chr3:10149882 C3orf24 0.64 9.14 0.45 6.38e-18 Alzheimer's disease; LUSC cis rs7789940 0.817 rs6946310 chr7:75936099 T/C cg10167463 chr7:75959203 YWHAG -0.51 -7.21 -0.37 3.83e-12 Multiple sclerosis; LUSC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg10018233 chr7:150070692 REPIN1 0.38 6.19 0.32 1.73e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg00149659 chr3:10157352 C3orf10 1.0 14.64 0.63 7.9e-38 Alzheimer's disease; LUSC cis rs709400 0.663 rs11623869 chr14:103883633 G/T cg12935359 chr14:103987150 CKB -0.56 -8.57 -0.42 3.85e-16 Body mass index; LUSC cis rs4499344 0.535 rs7260509 chr19:33121595 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.71 11.15 0.52 9.6e-25 Mean platelet volume; LUSC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg19592336 chr6:28129416 ZNF389 0.48 6.27 0.32 1.11e-9 Depression; LUSC cis rs7267979 0.932 rs417110 chr20:25458297 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.83 0.75 2.5e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg00509249 chr6:109615579 CCDC162 -0.34 -6.03 -0.31 4.24e-9 Reticulocyte fraction of red cells; LUSC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 8.96 0.44 2.3e-17 Schizophrenia; LUSC cis rs892085 0.681 rs3826803 chr19:10883126 C/G cg17710535 chr19:10819994 QTRT1 -0.35 -5.74 -0.3 2.09e-8 Psoriasis vulgaris;Psoriasis; LUSC cis rs10266483 1.000 rs10266483 chr7:63733331 A/G cg24201672 chr7:64023550 ZNF680 -0.43 -5.97 -0.31 6.02e-9 Response to statin therapy; LUSC cis rs11098499 0.865 rs2389809 chr4:120377399 T/C cg24375607 chr4:120327624 NA 0.78 11.63 0.54 1.83e-26 Corneal astigmatism; LUSC cis rs9325144 0.600 rs6582630 chr12:38743508 A/G cg26384229 chr12:38710491 ALG10B -0.6 -9.48 -0.46 4.83e-19 Morning vs. evening chronotype; LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs12682352 0.535 rs12677550 chr8:8644322 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.53 -0.34 2.47e-10 Neuroticism; LUSC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg02034447 chr16:89574710 SPG7 0.4 6.01 0.31 4.82e-9 Multiple myeloma (IgH translocation); LUSC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg14552801 chr7:65878734 NA -0.38 -5.95 -0.31 6.75e-9 Aortic root size; LUSC trans rs12902680 0.706 rs28575923 chr15:46525609 G/A cg04321580 chr8:143696133 ARC -0.42 -6.0 -0.31 5e-9 Neuroticism; LUSC cis rs62229266 0.804 rs998383 chr21:37445739 C/G cg12218747 chr21:37451666 NA -0.39 -5.73 -0.3 2.29e-8 Mitral valve prolapse; LUSC cis rs2200578 0.836 rs72957179 chr2:99693578 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.55 6.63 0.34 1.36e-10 IgG glycosylation; LUSC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg14061069 chr19:46274453 DMPK 0.67 13.89 0.61 6.14e-35 Coronary artery disease; LUSC trans rs60843830 1.000 rs17714252 chr2:285471 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 10.81 0.51 1.43e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6840360 0.593 rs28602726 chr4:152499788 T/C cg22705602 chr4:152727874 NA -0.34 -6.82 -0.35 4.21e-11 Intelligence (multi-trait analysis); LUSC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.6 -8.7 -0.43 1.58e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs71435601 0.527 rs544039 chr2:21398985 C/A cg20757404 chr19:378427 NA 0.37 6.01 0.31 4.87e-9 Cholesterol, total; LUSC cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.36 -6.27 -0.32 1.11e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10028773 0.666 rs12498657 chr4:120262866 G/C cg24375607 chr4:120327624 NA 0.7 11.14 0.52 1.03e-24 Educational attainment; LUSC cis rs7605827 0.930 rs11692377 chr2:15659848 C/T cg19274914 chr2:15703543 NA 0.47 9.19 0.45 4.24e-18 Educational attainment (years of education); LUSC cis rs3806843 0.966 rs7710380 chr5:140156264 T/C cg26395211 chr5:140044315 WDR55 -0.37 -5.74 -0.3 2.17e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6669008 1.000 rs6669008 chr1:114166561 A/G cg13572289 chr1:114447746 DCLRE1B;AP4B1 -0.36 -5.77 -0.3 1.78e-8 Bacteremia; LUSC cis rs2688608 1.000 rs2688608 chr10:75658349 G/T cg17411546 chr10:75410026 SYNPO2L -0.43 -6.43 -0.33 4.5e-10 Inflammatory bowel disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14550653 chr6:52149695 MCM3 -0.44 -6.45 -0.33 3.88e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8056893 0.879 rs3961282 chr16:68365157 A/G cg02226672 chr16:68398533 SMPD3 0.33 5.91 0.31 8.67e-9 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs4132509 0.696 rs12023642 chr1:243767826 T/G cg21452805 chr1:244014465 NA 0.64 6.31 0.33 8.91e-10 RR interval (heart rate); LUSC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg16049864 chr8:95962084 TP53INP1 0.63 10.96 0.51 4.35e-24 Type 2 diabetes; LUSC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg17507749 chr15:85114479 UBE2QP1 0.68 8.55 0.42 4.36e-16 Schizophrenia; LUSC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.41 6.37 0.33 6.33e-10 Platelet count; LUSC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg10792982 chr14:105748885 BRF1 0.48 8.68 0.43 1.75e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs11098499 0.575 rs907205 chr4:120238664 G/C cg09307838 chr4:120376055 NA 0.69 10.51 0.5 1.65e-22 Corneal astigmatism; LUSC cis rs9650315 0.810 rs67283156 chr8:57202814 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.76e-12 Height; LUSC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg09323728 chr8:95962352 TP53INP1 0.33 6.07 0.32 3.42e-9 Type 2 diabetes; LUSC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.77 -0.43 8.98e-17 Gut microbiome composition (summer); LUSC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg09267113 chr7:98030324 BAIAP2L1 0.39 6.0 0.31 5.11e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs7181230 0.885 rs17723133 chr15:40365418 A/G cg22705835 chr10:65332833 REEP3 0.39 6.34 0.33 7.67e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.76 -0.3 1.87e-8 Depression; LUSC cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.43 -0.46 6.97e-19 Chronic sinus infection; LUSC cis rs3768617 0.510 rs6691755 chr1:183099821 G/A ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg10523679 chr1:76189770 ACADM -0.51 -7.47 -0.38 6.99e-13 Daytime sleep phenotypes; LUSC cis rs4285028 0.948 rs34478505 chr3:121694071 C/T cg11130432 chr3:121712080 ILDR1 -0.64 -9.8 -0.47 4.37e-20 Multiple sclerosis; LUSC cis rs9811920 0.809 rs4928153 chr3:99808445 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.35 -6.52 -0.34 2.55e-10 Axial length; LUSC cis rs7843479 0.562 rs6988010 chr8:21859084 G/A cg17168535 chr8:21777572 XPO7 0.8 14.16 0.61 5.36e-36 Mean corpuscular volume; LUSC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg22875332 chr1:76189707 ACADM 0.86 14.01 0.61 2.16e-35 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs877282 0.583 rs10904564 chr10:819459 C/G cg13042288 chr15:90349979 ANPEP -0.42 -6.34 -0.33 7.44e-10 Uric acid levels; LUSC trans rs9929218 0.507 rs62057805 chr16:68742390 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.05 22.61 0.78 2.48e-69 Colorectal cancer; LUSC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg27170947 chr2:26402098 FAM59B -0.64 -9.3 -0.45 1.82e-18 Gut microbiome composition (summer); LUSC cis rs4664308 0.710 rs13001911 chr2:161020703 G/C cg03641300 chr2:160917029 PLA2R1 -0.61 -10.34 -0.49 6.11e-22 Idiopathic membranous nephropathy; LUSC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2282300 0.956 rs594937 chr11:30390132 A/G cg25418670 chr11:30344373 C11orf46 0.51 7.16 0.36 5.23e-12 Morning vs. evening chronotype; LUSC trans rs6952808 0.760 rs11764960 chr7:1950532 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.06 0.31 3.71e-9 Bipolar disorder and schizophrenia; LUSC cis rs870825 0.616 rs28500698 chr4:185627746 A/C cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs9326248 0.954 rs8521 chr11:117067699 C/T cg01368799 chr11:117014884 PAFAH1B2 0.5 6.58 0.34 1.82e-10 Blood protein levels; LUSC cis rs9304742 0.646 rs10408610 chr19:53463913 G/A cg09915433 chr19:53449742 NA -0.57 -9.27 -0.45 2.38e-18 Psoriasis; LUSC trans rs208520 0.690 rs10944872 chr6:66708239 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 16.23 0.66 4.45e-44 Exhaled nitric oxide output; LUSC cis rs12421382 0.558 rs12422001 chr11:109391880 A/G cg11473876 chr11:109292803 C11orf87 0.41 6.57 0.34 1.94e-10 Schizophrenia; LUSC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg26441486 chr22:50317300 CRELD2 -0.55 -8.28 -0.41 2.94e-15 Schizophrenia; LUSC cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg06454157 chr6:167490870 NA -0.24 -6.04 -0.31 4.19e-9 Crohn's disease; LUSC cis rs80130819 0.636 rs2634690 chr12:48712638 C/T cg24011408 chr12:48396354 COL2A1 0.46 5.95 0.31 6.73e-9 Prostate cancer; LUSC cis rs28655083 0.828 rs11640648 chr16:77122494 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.52 7.91 0.4 3.69e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2617583 0.967 rs2550948 chr5:1450444 C/T cg07148919 chr5:1466943 LPCAT1 0.38 5.83 0.3 1.3e-8 Breast cancer; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg08224763 chr17:6917993 C17orf49 0.49 6.38 0.33 5.8e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6500602 0.826 rs7205189 chr16:4460114 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 6.79 0.35 5.1e-11 Schizophrenia; LUSC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg07936489 chr17:37558343 FBXL20 0.72 10.04 0.48 6.43e-21 Glomerular filtration rate (creatinine); LUSC cis rs7215564 0.908 rs35374347 chr17:78642244 C/T cg23238734 chr17:78661607 RPTOR 0.5 6.2 0.32 1.69e-9 Myopia (pathological); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18045831 chr1:19577885 MRTO4;KIAA0090 0.35 6.32 0.33 8.39e-10 Triglycerides; LUSC cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.42 -0.38 9.65e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs59698941 0.943 rs66483023 chr5:132257748 A/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs2227930 0.506 rs9867210 chr3:142132749 T/C cg16271453 chr3:142027066 XRN1 -0.54 -9.64 -0.47 1.51e-19 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs12681287 0.547 rs71502658 chr8:87478785 T/A cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC trans rs3960554 0.740 rs10216079 chr7:75690988 A/C cg19862616 chr7:65841803 NCRNA00174 0.85 9.54 0.46 3.1400000000000002e-19 Eotaxin levels; LUSC cis rs66569888 0.789 rs17213510 chr2:106742778 T/C cg15412446 chr2:106886593 NA -0.49 -5.86 -0.31 1.09e-8 Facial morphology (factor 23); LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg10802521 chr3:52805072 NEK4 -0.54 -8.54 -0.42 4.78e-16 Bipolar disorder; LUSC cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.16 -0.36 5.12e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4242434 0.854 rs11782130 chr8:22452357 G/T cg03733263 chr8:22462867 KIAA1967 0.99 17.54 0.69 2.73e-49 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs1371867 0.846 rs1692006 chr8:101252462 C/T cg00191853 chr8:101177733 SPAG1 0.36 5.9 0.31 8.98e-9 Atrioventricular conduction; LUSC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg17376030 chr22:41985996 PMM1 -0.48 -5.9 -0.31 8.71e-9 Vitiligo; LUSC cis rs727505 0.821 rs73225498 chr7:124704197 C/T cg23710748 chr7:124431027 NA -0.4 -6.98 -0.36 1.63e-11 Lewy body disease; LUSC cis rs8058578 0.943 rs3747486 chr16:30786927 C/T cg02466173 chr16:30829666 NA -0.6 -11.2 -0.52 6.15e-25 Multiple myeloma; LUSC cis rs227833 1.000 rs227835 chr6:44682316 A/G cg20913747 chr6:44695427 NA 0.38 5.76 0.3 1.87e-8 Monobrow; LUSC cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs2769264 0.505 rs4246526 chr1:151403916 G/T cg18801370 chr1:151430492 POGZ 0.69 8.44 0.42 9.58e-16 Blood trace element (Cu levels); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27634258 chr15:51058042 SPPL2A -0.47 -6.48 -0.33 3.39e-10 Bipolar disorder and schizophrenia; LUSC cis rs6599077 1.000 rs2371140 chr3:40098381 A/G cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs34779708 0.897 rs7900480 chr10:35338699 A/G cg03585969 chr10:35415529 CREM -0.57 -8.34 -0.42 1.97e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2011503 0.509 rs884480 chr19:19773923 G/A cg11584989 chr19:19387371 SF4 0.51 5.82 0.3 1.41e-8 Bipolar disorder; LUSC trans rs2048656 0.605 rs13249234 chr8:9650401 T/C cg06636001 chr8:8085503 FLJ10661 0.46 6.43 0.33 4.4e-10 Schizophrenia; LUSC cis rs977987 0.843 rs59155720 chr16:75483806 A/G cg03315344 chr16:75512273 CHST6 0.49 9.56 0.46 2.74e-19 Dupuytren's disease; LUSC cis rs10876993 0.928 rs1689586 chr12:58079586 A/T cg18357645 chr12:58087776 OS9 0.58 8.8 0.43 7.25e-17 Celiac disease or Rheumatoid arthritis; LUSC cis rs10203711 0.966 rs4998693 chr2:239564753 G/T cg14580085 chr2:239553406 NA 0.41 6.96 0.36 1.76e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg18479299 chr3:125709523 NA -0.52 -5.94 -0.31 7.16e-9 Blood pressure (smoking interaction); LUSC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.5 -0.38 5.77e-13 Aortic root size; LUSC cis rs2798269 1.000 rs2476638 chr13:22133729 T/C cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.13 -0.32 2.42e-9 PR segment; LUSC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg03806693 chr22:41940476 POLR3H 0.97 14.15 0.61 6.21e-36 Vitiligo; LUSC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg13628971 chr7:2884303 GNA12 0.42 6.27 0.32 1.11e-9 Height; LUSC cis rs4908769 0.553 rs301792 chr1:8468278 A/G cg00546117 chr1:8445545 RERE -0.28 -5.65 -0.3 3.37e-8 Allergy; LUSC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg19774624 chr17:42201019 HDAC5 0.7 10.29 0.49 9.36e-22 Total body bone mineral density; LUSC cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg21573476 chr21:45109991 RRP1B 0.4 6.69 0.34 9.26e-11 Mean corpuscular volume; LUSC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9549367 0.789 rs9577220 chr13:113908294 T/A cg00898013 chr13:113819073 PROZ -0.53 -7.85 -0.39 5.78e-14 Platelet distribution width; LUSC trans rs2243480 0.708 rs781141 chr7:65438553 A/G cg10756647 chr7:56101905 PSPH 0.85 8.34 0.42 2.04e-15 Diabetic kidney disease; LUSC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs12291225 0.679 rs11023172 chr11:14295367 C/G cg05501817 chr11:14380813 RRAS2 -0.57 -8.9 -0.44 3.72e-17 Sense of smell; LUSC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.57 0.38 3.58e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs9847710 0.933 rs1529544 chr3:53039455 A/G cg18404041 chr3:52824283 ITIH1 -0.37 -6.67 -0.34 1.05e-10 Ulcerative colitis; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.31 0.64 1.89e-40 Platelet count; LUSC cis rs7923609 0.967 rs7082470 chr10:65277026 G/A cg01631684 chr10:65280961 REEP3 -0.41 -6.39 -0.33 5.65e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs17401966 0.838 rs12132134 chr1:10378428 A/G cg19773385 chr1:10388646 KIF1B -0.49 -8.37 -0.42 1.57e-15 Hepatocellular carcinoma; LUSC cis rs1322512 0.917 rs2623944 chr6:152959314 C/T cg27316956 chr6:152958899 SYNE1 -0.37 -6.2 -0.32 1.62e-9 Tonometry; LUSC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg18225595 chr11:63971243 STIP1 0.52 6.54 0.34 2.38e-10 Mean platelet volume; LUSC cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.91 -0.35 2.44e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs73001065 0.591 rs11668386 chr19:19531910 A/G cg03709012 chr19:19516395 GATAD2A 1.0 9.39 0.46 9.68e-19 LDL cholesterol; LUSC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg12257692 chr3:49977190 RBM6 0.24 6.66 0.34 1.16e-10 Body mass index; LUSC cis rs2120019 1.000 rs35736167 chr15:75332002 T/G cg17294928 chr15:75287854 SCAMP5 -0.92 -13.07 -0.58 8.12e-32 Blood trace element (Zn levels); LUSC cis rs11190604 0.943 rs2495744 chr10:102329409 C/T cg07080220 chr10:102295463 HIF1AN 0.69 9.54 0.46 3.03e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9649213 0.614 rs10953254 chr7:97914305 A/G cg08684580 chr7:98029266 BAIAP2L1 0.38 5.73 0.3 2.19e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg06191203 chr2:152266755 RIF1 -0.55 -7.27 -0.37 2.64e-12 Lung cancer; LUSC cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg23649088 chr2:200775458 C2orf69 -0.5 -6.86 -0.35 3.41e-11 Schizophrenia; LUSC cis rs865483 0.860 rs862490 chr17:35850275 T/C cg06716730 chr17:35851459 DUSP14 0.29 6.61 0.34 1.51e-10 Monocyte count; LUSC cis rs7241530 0.662 rs924890 chr18:75900657 C/T cg14642773 chr18:75888474 NA 0.4 6.11 0.32 2.71e-9 Educational attainment (years of education); LUSC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg26769984 chr7:1090371 C7orf50 0.57 7.86 0.4 5.34e-14 Bronchopulmonary dysplasia; LUSC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg22903657 chr4:1355424 KIAA1530 -0.37 -6.01 -0.31 4.82e-9 Longevity; LUSC trans rs11992162 0.573 rs13264994 chr8:11782759 G/A cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.46e-10 Monocyte count; LUSC cis rs1728785 0.901 rs11865339 chr16:68565296 C/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg11764359 chr7:65958608 NA 0.8 13.45 0.59 3.01e-33 Aortic root size; LUSC cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg01028140 chr2:1542097 TPO 0.59 8.03 0.4 1.74e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7216064 1.000 rs2046323 chr17:65849927 T/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.32 -0.45 1.62e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs8072100 0.967 rs62076549 chr17:45579555 T/G cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.78 0.3 1.68e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6696846 0.765 rs61822567 chr1:205078725 T/C cg21545522 chr1:205238299 TMCC2 0.46 8.6 0.43 3.05e-16 Red blood cell count; LUSC cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg00012203 chr2:219082015 ARPC2 -0.77 -13.72 -0.6 2.88e-34 Colorectal cancer; LUSC cis rs4711350 0.765 rs943473 chr6:33743651 G/C cg18005901 chr6:33739558 LEMD2 -0.39 -5.8 -0.3 1.53e-8 Schizophrenia; LUSC cis rs1507153 0.523 rs236884 chr6:79319525 C/G cg05283184 chr6:79620031 NA 0.38 6.95 0.36 1.94e-11 Sjögren's syndrome; LUSC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg21433313 chr16:3507492 NAT15 0.81 8.76 0.43 1e-16 Tuberculosis; LUSC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg24399712 chr22:39784796 NA -0.63 -10.44 -0.5 2.8e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg11494091 chr17:61959527 GH2 0.69 14.72 0.63 3.91e-38 Prudent dietary pattern; LUSC cis rs8141797 0.901 rs2330722 chr22:24491488 C/G cg00411358 chr22:24577142 SUSD2 0.61 6.09 0.32 3.14e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC trans rs11700980 0.551 rs2832035 chr21:30115032 C/T cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs2798269 0.902 rs1359190 chr13:22096611 T/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.79 -0.3 1.61e-8 PR segment; LUSC cis rs727505 1.000 rs720614 chr7:124452790 T/C cg23710748 chr7:124431027 NA -0.43 -7.79 -0.39 8.52e-14 Lewy body disease; LUSC trans rs35110281 0.591 rs86138 chr21:44932398 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.05 0.48 6.24e-21 Mean corpuscular volume; LUSC trans rs35110281 0.744 rs162395 chr21:44945759 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.56 0.46 2.66e-19 Mean corpuscular volume; LUSC trans rs7939886 0.920 rs10431119 chr11:55977069 C/T cg15704280 chr7:45808275 SEPT13 0.91 6.86 0.35 3.36e-11 Myopia (pathological); LUSC cis rs709400 0.663 rs11628213 chr14:103952453 A/C cg24130564 chr14:104152367 KLC1 -0.41 -5.75 -0.3 1.98e-8 Body mass index; LUSC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg02269571 chr22:50332266 NA 0.59 8.72 0.43 1.33e-16 Schizophrenia; LUSC cis rs2115536 0.692 rs8036559 chr15:80170563 C/T cg02196730 chr15:80188777 MTHFS 0.39 5.92 0.31 7.97e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7312933 0.567 rs11181399 chr12:42666412 G/A cg01256987 chr12:42539512 GXYLT1 -0.42 -7.89 -0.4 4.42e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg00083206 chr6:110721305 DDO -0.46 -8.45 -0.42 8.94e-16 Platelet distribution width; LUSC cis rs6582630 0.539 rs4882324 chr12:38499180 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.81 -0.35 4.45e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs17095355 1.000 rs59804002 chr10:111692043 G/T cg00817464 chr10:111662876 XPNPEP1 -0.63 -7.35 -0.37 1.54e-12 Biliary atresia; LUSC cis rs11190604 1.000 rs2495759 chr10:102320363 C/T cg07080220 chr10:102295463 HIF1AN 0.67 7.88 0.4 4.58e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3820068 0.705 rs4645992 chr1:15849742 G/T cg17385448 chr1:15911702 AGMAT 0.39 6.03 0.31 4.23e-9 Systolic blood pressure; LUSC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg10909506 chr17:38081995 ORMDL3 0.34 6.02 0.31 4.69e-9 Self-reported allergy; LUSC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg13902645 chr11:5959945 NA -0.61 -8.34 -0.42 1.92e-15 DNA methylation (variation); LUSC cis rs644799 0.687 rs11021318 chr11:95522996 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.84 0.6 9.47e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg22532475 chr10:104410764 TRIM8 0.33 6.65 0.34 1.22e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.28e-9 Menopause (age at onset); LUSC cis rs240764 0.782 rs151637 chr6:101104191 C/T cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs11166629 0.502 rs6577717 chr8:135653832 G/T cg27224718 chr8:135614730 ZFAT 0.51 7.88 0.4 4.65e-14 Smoking quantity; LUSC cis rs1728785 1.000 rs7196104 chr16:68579746 C/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC trans rs1728785 0.901 rs698715 chr16:68560896 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.63 0.39 2.44e-13 Ulcerative colitis; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg27588902 chr6:42928151 GNMT -0.3 -6.6 -0.34 1.65e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2235642 0.525 rs2667688 chr16:1561446 A/G cg26528668 chr16:1614120 IFT140 0.4 5.81 0.3 1.42e-8 Coronary artery disease; LUSC cis rs34421088 0.560 rs2245357 chr8:11399484 A/T cg21775007 chr8:11205619 TDH -0.53 -8.02 -0.4 1.83e-14 Neuroticism; LUSC cis rs9300255 0.544 rs2049114 chr12:123657338 T/C cg00376283 chr12:123451042 ABCB9 0.67 8.43 0.42 1.07e-15 Neutrophil percentage of white cells; LUSC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg23625390 chr15:77176239 SCAPER 0.46 6.97 0.36 1.66e-11 Blood metabolite levels; LUSC cis rs10465746 0.780 rs1952065 chr1:84464205 T/C cg10977910 chr1:84465055 TTLL7 0.43 6.08 0.32 3.28e-9 Obesity-related traits; LUSC cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.67 0.6 4.14e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3820928 0.874 rs2396452 chr2:227838040 T/G cg11843606 chr2:227700838 RHBDD1 -0.55 -7.94 -0.4 3.16e-14 Pulmonary function; LUSC cis rs11608355 0.515 rs34038572 chr12:109901657 A/G cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs72960926 0.744 rs55795936 chr6:75006841 A/G cg03266952 chr6:74778945 NA -0.75 -6.61 -0.34 1.49e-10 Metabolite levels (MHPG); LUSC cis rs62432291 0.681 rs433786 chr6:159665946 T/A cg14500486 chr6:159655392 FNDC1 -0.56 -5.99 -0.31 5.36e-9 Joint mobility (Beighton score); LUSC cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg26384229 chr12:38710491 ALG10B 0.88 14.95 0.63 4.68e-39 Bladder cancer; LUSC cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg04362960 chr10:104952993 NT5C2 0.57 8.31 0.41 2.36e-15 Arsenic metabolism; LUSC cis rs7568458 0.837 rs3770098 chr2:85805367 C/A cg17127132 chr2:85788382 GGCX 0.49 7.92 0.4 3.6e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7814319 0.966 rs10955069 chr8:97253788 C/T cg20787634 chr8:97240163 UQCRB -0.35 -6.12 -0.32 2.68e-9 Lung function (FVC); LUSC cis rs7107174 1.000 rs2373115 chr11:78091150 G/T cg02023728 chr11:77925099 USP35 0.41 6.24 0.32 1.34e-9 Testicular germ cell tumor; LUSC cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg15345415 chr5:151150903 G3BP1 0.34 5.99 0.31 5.53e-9 Educational attainment (years of education); LUSC cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.35 0.37 1.53e-12 Motion sickness; LUSC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg10523679 chr1:76189770 ACADM 0.89 14.21 0.61 3.55e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9326248 1.000 rs7946257 chr11:117053165 A/G cg10130564 chr11:117069849 TAGLN 0.38 6.49 0.33 3.07e-10 Blood protein levels; LUSC cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg05347473 chr6:146136440 FBXO30 0.59 10.57 0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs440932 1.000 rs365309 chr8:9026940 C/T cg06636001 chr8:8085503 FLJ10661 -0.42 -5.94 -0.31 7.17e-9 High light scatter reticulocyte percentage of red cells; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg03387311 chr17:17106229 PLD6 -0.37 -6.07 -0.32 3.49e-9 N-glycan levels; LUSC cis rs1372520 0.627 rs2737025 chr4:90719192 A/G cg01966878 chr4:90757139 SNCA -0.43 -6.22 -0.32 1.49e-9 Neuroticism; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg14159672 chr1:205819179 PM20D1 0.85 15.36 0.64 1.22e-40 Menarche (age at onset); LUSC cis rs10435719 0.638 rs67146188 chr8:11782433 A/G cg21775007 chr8:11205619 TDH -0.41 -5.79 -0.3 1.62e-8 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4704187 0.687 rs1903839 chr5:74421397 A/G cg03227963 chr5:74354835 NA 0.32 6.89 0.35 2.72e-11 Response to amphetamines; LUSC cis rs1524927 0.966 rs7789402 chr7:96353085 A/G cg03808172 chr7:96339361 SHFM1 0.42 6.52 0.34 2.53e-10 Total body bone mineral density; LUSC cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg05347473 chr6:146136440 FBXO30 0.41 6.91 0.35 2.54e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg09877947 chr5:131593287 PDLIM4 -0.42 -6.15 -0.32 2.17e-9 Blood metabolite levels; LUSC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg22535103 chr8:58192502 C8orf71 -0.57 -6.72 -0.34 8.09e-11 Developmental language disorder (linguistic errors); LUSC cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg08917208 chr2:24149416 ATAD2B 0.56 6.36 0.33 6.82e-10 Lymphocyte counts; LUSC cis rs447735 0.507 rs11645271 chr16:89729125 G/T cg03605463 chr16:89740564 NA -0.53 -8.37 -0.42 1.59e-15 Hemoglobin concentration; LUSC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg04450456 chr4:17643702 FAM184B 0.41 6.93 0.35 2.2e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9677476 0.731 rs28690417 chr2:232064182 G/A cg07929768 chr2:232055508 NA 0.4 6.87 0.35 3.15e-11 Food antigen IgG levels; LUSC trans rs10506458 1.000 rs1495013 chr12:63428188 C/T cg22491629 chr6:157744540 C6orf35 -0.91 -10.85 -0.51 1.08e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs10905065 1.000 rs10737013 chr10:5746772 C/G cg11519256 chr10:5708881 ASB13 0.39 5.84 0.3 1.25e-8 Menopause (age at onset); LUSC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg08470875 chr2:26401718 FAM59B -0.63 -8.71 -0.43 1.45e-16 Gut microbiome composition (summer); LUSC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg05855489 chr10:104503620 C10orf26 -0.66 -10.09 -0.48 4.54e-21 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4363385 0.693 rs56347903 chr1:152932175 T/G cg07796016 chr1:152779584 LCE1C -0.45 -6.49 -0.33 3.04e-10 Inflammatory skin disease; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg11494091 chr17:61959527 GH2 0.66 13.94 0.61 3.9e-35 Prudent dietary pattern; LUSC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg06671706 chr8:8559999 CLDN23 0.49 6.43 0.33 4.36e-10 Obesity-related traits; LUSC cis rs61931739 0.817 rs2203086 chr12:34232590 T/C cg06521331 chr12:34319734 NA -0.37 -6.46 -0.33 3.79e-10 Morning vs. evening chronotype; LUSC cis rs9807989 0.839 rs4988958 chr2:102968285 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs9653442 0.622 rs11685341 chr2:100636757 A/G cg22139774 chr2:100720529 AFF3 0.41 6.98 0.36 1.57e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg23711669 chr6:146136114 FBXO30 -0.78 -12.9 -0.58 3.58e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC cis rs9487051 0.768 rs427960 chr6:109524939 C/T cg00509249 chr6:109615579 CCDC162 -0.36 -6.05 -0.31 3.91e-9 Reticulocyte fraction of red cells; LUSC cis rs76878669 0.561 rs3177514 chr11:66130358 T/G cg18002602 chr11:66138449 SLC29A2 0.45 8.04 0.4 1.55e-14 Educational attainment (years of education); LUSC cis rs354225 0.544 rs10169975 chr2:54808159 C/T cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs11051970 0.614 rs2728684 chr12:32575665 C/A cg02745156 chr12:32552066 NA 0.37 5.92 0.31 8.03e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11031096 0.502 rs7935824 chr11:4046900 C/G cg18678763 chr11:4115507 RRM1 -0.49 -6.45 -0.33 3.94e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs4478858 0.684 rs12135540 chr1:31764693 G/A cg00250761 chr1:31883323 NA -0.35 -8.37 -0.42 1.61e-15 Alcohol dependence; LUSC cis rs7264396 0.563 rs6060567 chr20:34288250 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.64 -0.43 2.38e-16 Total cholesterol levels; LUSC cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg01884057 chr2:25150051 NA 0.46 10.6 0.5 8.23e-23 Body mass index in non-asthmatics; LUSC cis rs921968 0.643 rs524902 chr2:219433357 A/C cg02176678 chr2:219576539 TTLL4 0.61 10.93 0.51 5.45e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs524023 1.000 rs3825018 chr11:64358809 G/A cg07220939 chr11:64358617 SLC22A12 -0.22 -5.67 -0.3 3.12e-8 Urate levels in obese individuals; LUSC trans rs9650657 0.571 rs11783247 chr8:10788875 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.85 -0.39 5.78e-14 Neuroticism; LUSC cis rs9300255 0.516 rs6488868 chr12:123799974 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg23758822 chr17:41437982 NA 1.03 17.11 0.68 1.46e-47 Menopause (age at onset); LUSC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg04398451 chr17:18023971 MYO15A 0.57 9.53 0.46 3.41e-19 Total body bone mineral density; LUSC trans rs12579753 0.917 rs71466033 chr12:82242187 C/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg04998671 chr14:104000505 TRMT61A -0.42 -6.17 -0.32 2.01e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg22868518 chr11:507468 RNH1 -0.59 -5.81 -0.3 1.47e-8 Body mass index; LUSC cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg01849466 chr14:104193079 ZFYVE21 -0.55 -9.02 -0.44 1.54e-17 Schizophrenia; LUSC cis rs2404602 0.692 rs35498563 chr15:76958868 C/T cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.25e-12 Blood metabolite levels; LUSC cis rs7945718 0.839 rs10831911 chr11:12834858 C/T cg25843174 chr11:12811716 TEAD1 0.3 6.86 0.35 3.26e-11 Educational attainment (years of education); LUSC cis rs2439831 0.850 rs16965120 chr15:44100342 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.83 8.3 0.41 2.55e-15 Lung cancer in ever smokers; LUSC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 12.99 0.58 1.61e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10782582 0.593 rs11801414 chr1:76124517 G/A cg10523679 chr1:76189770 ACADM -0.49 -7.16 -0.36 5.33e-12 Daytime sleep phenotypes; LUSC cis rs500891 0.553 rs12209499 chr6:84147303 A/G cg08257003 chr6:84140564 ME1 0.37 9.29 0.45 2.06e-18 Platelet-derived growth factor BB levels; LUSC cis rs12579753 0.871 rs10862364 chr12:82201280 C/T cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs12950390 0.893 rs72831644 chr17:45824391 T/C cg03474202 chr17:45855739 NA -0.28 -6.32 -0.33 8.55e-10 IgG glycosylation; LUSC cis rs12519773 0.526 rs6897863 chr5:92512481 A/C cg18783429 chr5:92414398 NA 0.33 7.02 0.36 1.21e-11 Migraine; LUSC cis rs9549367 0.774 rs9549696 chr13:113875062 C/T cg00898013 chr13:113819073 PROZ -0.59 -8.68 -0.43 1.72e-16 Platelet distribution width; LUSC cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg05347473 chr6:146136440 FBXO30 0.39 6.61 0.34 1.53e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg11244672 chr19:19639970 YJEFN3 -0.61 -7.59 -0.38 3.3e-13 Bipolar disorder; LUSC cis rs6087990 0.871 rs2424905 chr20:31352927 T/C cg13636640 chr20:31349939 DNMT3B 1.01 22.53 0.78 5.45e-69 Ulcerative colitis; LUSC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.3 0.49 8.56e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs10876993 0.928 rs1678532 chr12:58055197 T/G cg18357645 chr12:58087776 OS9 0.52 7.72 0.39 1.32e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs1215050 0.740 rs783938 chr4:99010336 A/T cg05340658 chr4:99064831 C4orf37 -0.44 -6.98 -0.36 1.65e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2798269 0.867 rs1539562 chr13:22117071 A/G cg18095732 chr13:22033692 ZDHHC20 -0.41 -6.34 -0.33 7.44e-10 PR segment; LUSC cis rs67981189 0.593 rs8007425 chr14:71508200 A/G cg15816911 chr14:71606274 NA 0.33 5.86 0.31 1.09e-8 Schizophrenia; LUSC cis rs9653442 0.500 rs72819191 chr2:100826572 A/G cg07810366 chr2:100720526 AFF3 0.5 7.92 0.4 3.57e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg25894440 chr7:65020034 NA 0.37 5.86 0.31 1.1e-8 Calcium levels; LUSC cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg04450456 chr4:17643702 FAM184B 0.39 6.53 0.34 2.44e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs367943 0.712 rs26967 chr5:112741467 C/G cg12552261 chr5:112820674 MCC 0.36 5.95 0.31 6.72e-9 Type 2 diabetes; LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg05165339 chr4:1420672 NA -0.28 -6.3 -0.33 9.57e-10 Longevity; LUSC cis rs7917772 0.582 rs10786685 chr10:104323103 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 10.41 0.5 3.54e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg06740227 chr12:86229804 RASSF9 0.37 5.84 0.3 1.27e-8 Major depressive disorder; LUSC trans rs61931739 0.534 rs7965503 chr12:34199349 A/G cg13010199 chr12:38710504 ALG10B 0.55 8.5 0.42 6.53e-16 Morning vs. evening chronotype; LUSC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs12692738 0.526 rs355854 chr2:165628693 T/C cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs34421088 0.560 rs1478898 chr8:11395079 G/A cg08975724 chr8:8085496 FLJ10661 -0.51 -7.61 -0.38 2.78e-13 Neuroticism; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg11193173 chr8:99837846 STK3 0.45 6.09 0.32 3.12e-9 Mosquito bite size; LUSC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs17125944 0.505 rs118053951 chr14:53259829 G/A cg00686598 chr14:53173677 PSMC6 1.26 11.09 0.52 1.56e-24 Alzheimer's disease (late onset); LUSC cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.69 0.83 1.71e-88 Chronic sinus infection; LUSC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg16423285 chr20:60520624 NA -0.47 -5.9 -0.31 8.91e-9 Body mass index; LUSC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg22903657 chr4:1355424 KIAA1530 -0.49 -8.09 -0.4 1.11e-14 Obesity-related traits; LUSC cis rs7824557 0.628 rs58283816 chr8:11192551 G/C cg21293242 chr8:11204541 TDH 0.32 5.91 0.31 8.27e-9 Retinal vascular caliber; LUSC cis rs9549367 0.826 rs35306827 chr13:113869045 G/A cg18105134 chr13:113819100 PROZ -0.74 -10.63 -0.5 6.44e-23 Platelet distribution width; LUSC cis rs3930017 1.000 rs3930016 chr7:76720449 A/G cg15770687 chr7:76625569 PMS2L11 0.42 5.92 0.31 7.83e-9 Body mass index; LUSC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg12257692 chr3:49977190 RBM6 -0.26 -7.13 -0.36 6.45e-12 Intelligence (multi-trait analysis); LUSC cis rs9388451 0.505 rs9372828 chr6:126175185 A/T cg05901451 chr6:126070800 HEY2 -0.65 -10.2 -0.49 1.88e-21 Brugada syndrome; LUSC cis rs713477 1.000 rs28604440 chr14:55911324 C/T cg13175173 chr14:55914753 NA -0.3 -6.31 -0.33 8.72e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs459571 0.959 rs408307 chr9:136892523 A/G cg01294253 chr9:136912663 BRD3 -0.36 -6.16 -0.32 2.15e-9 Platelet distribution width; LUSC cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg04586622 chr2:25135609 ADCY3 0.43 9.16 0.45 5.26e-18 Body mass index; LUSC cis rs28830936 1.000 rs11632424 chr15:42095351 G/A cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.77 -0.3 1.78e-8 Diastolic blood pressure; LUSC cis rs6961069 0.645 rs1524596 chr7:80229313 G/C cg04458919 chr7:80252533 CD36 -0.41 -7.2 -0.37 4.05e-12 Platelet count; LUSC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.74 -0.3 2.14e-8 Depression; LUSC cis rs9434723 1.000 rs9434723 chr1:9292282 C/T cg04199779 chr1:9294473 H6PD 0.56 6.48 0.33 3.3e-10 Height; LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg18765753 chr7:1198926 ZFAND2A -0.4 -7.41 -0.38 1.04e-12 Longevity;Endometriosis; LUSC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.66e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg22535103 chr8:58192502 C8orf71 -0.65 -7.32 -0.37 1.89e-12 Developmental language disorder (linguistic errors); LUSC cis rs950169 0.840 rs4842853 chr15:84942304 G/T cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs1448094 0.836 rs6539935 chr12:86376809 T/C cg02569458 chr12:86230093 RASSF9 0.4 6.42 0.33 4.6e-10 Major depressive disorder; LUSC cis rs10992471 0.729 rs7042335 chr9:95122547 C/T cg14631576 chr9:95140430 CENPP -0.35 -6.15 -0.32 2.24e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs11098499 0.863 rs1552095 chr4:120460306 A/G cg24375607 chr4:120327624 NA 0.78 11.04 0.52 2.38e-24 Corneal astigmatism; LUSC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs3087591 1.000 rs984125 chr17:29547254 A/G cg24425628 chr17:29625626 OMG;NF1 0.6 8.94 0.44 2.78e-17 Hip circumference; LUSC cis rs2346177 0.542 rs718849 chr2:46698116 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.59 -9.27 -0.45 2.29e-18 HDL cholesterol; LUSC cis rs244293 1.000 rs244292 chr17:53230734 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.83 -0.3 1.34e-8 Menarche (age at onset); LUSC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs950776 0.593 rs555018 chr15:78879242 G/A cg06917634 chr15:78832804 PSMA4 -0.73 -12.48 -0.56 1.31e-29 Sudden cardiac arrest; LUSC cis rs71386921 1 rs71386921 chr10:27478698 AAT/A cg14240646 chr10:27532245 ACBD5 -0.68 -8.2 -0.41 5.35e-15 Breast cancer; LUSC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.57 0.46 2.47e-19 Mean platelet volume; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg03188948 chr7:1209495 NA 0.66 7.29 0.37 2.2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.93 0.35 2.24e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg21251018 chr6:28226885 NKAPL -0.31 -5.88 -0.31 9.99e-9 Cardiac Troponin-T levels; LUSC cis rs12893668 0.703 rs4906335 chr14:104021141 C/A cg01849466 chr14:104193079 ZFYVE21 -0.42 -5.79 -0.3 1.65e-8 Reticulocyte count; LUSC trans rs629535 0.814 rs72654071 chr8:70079484 A/G cg21567404 chr3:27674614 NA -0.97 -15.59 -0.65 1.43e-41 Dupuytren's disease; LUSC cis rs3755132 0.929 rs68147799 chr2:15754346 T/G cg12888861 chr2:15731646 DDX1 0.52 7.48 0.38 6.45e-13 Wilms tumor; LUSC cis rs8060686 0.641 rs113502835 chr16:68238965 A/T cg04539111 chr16:67997858 SLC12A4 -0.43 -5.68 -0.3 2.96e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs7980799 0.905 rs4244866 chr12:33511983 G/C cg26384229 chr12:38710491 ALG10B -0.42 -6.04 -0.31 4.17e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.55 7.56 0.38 3.96e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg11871910 chr12:69753446 YEATS4 0.64 9.73 0.47 7.23e-20 Blood protein levels; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg01879757 chr17:41196368 BRCA1 -0.47 -7.18 -0.37 4.53e-12 Menopause (age at onset); LUSC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg17366294 chr4:99064904 C4orf37 0.59 10.54 0.5 1.24e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2073300 1.000 rs6048803 chr20:23438889 A/G cg09953122 chr20:23471693 CST8 -0.73 -6.43 -0.33 4.33e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs3755132 0.929 rs4668945 chr2:15764078 G/C cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs10992471 0.630 rs10992322 chr9:95159196 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.89 -0.35 2.77e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg15605315 chr1:45957053 TESK2 0.39 5.67 0.3 3.12e-8 Red blood cell count;Reticulocyte count; LUSC cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs17540621 0.793 rs114980657 chr2:47214280 G/A cg23978866 chr2:47230407 TTC7A -0.97 -6.65 -0.34 1.2e-10 Response to statin therapy; LUSC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg18402987 chr7:1209562 NA 0.44 5.92 0.31 8.13e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12101261 0.580 rs3783950 chr14:81448282 C/G cg06600135 chr14:81408086 NA -0.45 -7.06 -0.36 9.84e-12 Graves' disease; LUSC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg16060761 chr17:80687452 NA -0.53 -8.09 -0.4 1.13e-14 Glycated hemoglobin levels; LUSC cis rs7131987 0.834 rs12228468 chr12:29453610 A/C cg09582351 chr12:29534625 ERGIC2 0.34 7.05 0.36 1.05e-11 QT interval; LUSC cis rs7512552 0.839 rs12045304 chr1:150399818 G/A cg15654264 chr1:150340011 RPRD2 0.62 10.24 0.49 1.44e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs12900413 0.603 rs2882678 chr15:90299542 A/G cg24249390 chr15:90295951 MESP1 -0.37 -5.9 -0.31 8.76e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.03 0.58 1.16e-31 Chronic sinus infection; LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg18099408 chr3:52552593 STAB1 -0.4 -6.84 -0.35 3.86e-11 Bipolar disorder; LUSC trans rs3858145 0.588 rs76854765 chr10:70037456 C/T cg04882175 chr6:131122610 NA -0.65 -8.7 -0.43 1.51e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg11812906 chr14:75593930 NEK9 -0.65 -10.61 -0.5 7.65e-23 Height; LUSC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg20302533 chr7:39170763 POU6F2 0.57 9.49 0.46 4.54e-19 IgG glycosylation; LUSC cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.54 0.69 2.89e-49 Chronic sinus infection; LUSC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg09835421 chr16:68378352 PRMT7 -0.56 -6.31 -0.33 8.67e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9300255 0.722 rs34997336 chr12:123829116 G/A cg00376283 chr12:123451042 ABCB9 -0.65 -7.67 -0.39 1.91e-13 Neutrophil percentage of white cells; LUSC cis rs7267979 1.000 rs2259926 chr20:25281733 T/C cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs73206853 0.841 rs61663407 chr12:111055128 A/G cg12870014 chr12:110450643 ANKRD13A 0.69 6.51 0.34 2.76e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg20744362 chr22:50050164 C22orf34 0.4 8.14 0.41 7.66e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.57 -8.37 -0.42 1.57e-15 Gut microbiome composition (summer); LUSC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs7582180 0.739 rs11687352 chr2:100919888 A/C cg12002119 chr2:101014098 CHST10 0.34 5.74 0.3 2.09e-8 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.744 rs35588238 chr7:1012006 G/A cg04102894 chr7:1000210 NA -0.27 -6.37 -0.33 6.27e-10 Bronchopulmonary dysplasia; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg05863683 chr7:1912471 MAD1L1 0.31 6.03 0.31 4.24e-9 Bipolar disorder and schizophrenia; LUSC cis rs12908161 1.000 rs62019469 chr15:85321220 T/C cg17173187 chr15:85201210 NMB 0.47 8.9 0.44 3.57e-17 Schizophrenia; LUSC cis rs34172651 0.917 rs11074651 chr16:24778409 A/G cg00339695 chr16:24857497 SLC5A11 0.36 6.57 0.34 1.9e-10 Intelligence (multi-trait analysis); LUSC cis rs7481584 0.624 rs511990 chr11:3052936 A/G cg08508325 chr11:3079039 CARS 0.37 8.32 0.41 2.24e-15 Calcium levels; LUSC cis rs62408225 0.722 rs17712288 chr6:90909157 G/A cg06866423 chr6:90926672 BACH2 0.41 6.44 0.33 4.09e-10 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1577917 1.000 rs10455158 chr6:86672825 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.44 -0.42 9.55e-16 Response to antipsychotic treatment; LUSC cis rs10883723 0.962 rs1056738 chr10:104236481 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 12.06 0.55 4.66e-28 Allergic disease (asthma, hay fever or eczema); LUSC trans rs10946292 0.706 rs6938545 chr6:170435570 T/C cg17832364 chr10:94847294 NA 0.38 6.26 0.32 1.17e-9 Obesity-related traits; LUSC trans rs11004008 1.000 rs7082950 chr10:55790727 C/T cg07892413 chr2:129076032 HS6ST1 -0.34 -5.96 -0.31 6.51e-9 Schizophrenia; LUSC cis rs1775715 0.707 rs2065443 chr10:32164236 C/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.66 0.34 1.14e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs950776 0.684 rs11637635 chr15:78877150 A/G cg06917634 chr15:78832804 PSMA4 -0.69 -11.21 -0.52 5.76e-25 Sudden cardiac arrest; LUSC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg03678062 chr6:149772716 ZC3H12D -0.32 -6.71 -0.34 8.19e-11 Dupuytren's disease; LUSC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg24531977 chr5:56204891 C5orf35 -0.54 -7.92 -0.4 3.5e-14 Breast cancer;Breast cancer (early onset); LUSC cis rs12950390 0.853 rs4794107 chr17:45843159 T/G cg03474202 chr17:45855739 NA -0.28 -6.43 -0.33 4.3e-10 IgG glycosylation; LUSC cis rs6582630 0.638 rs7963994 chr12:38555535 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.36 -0.42 1.77e-15 Drug-induced liver injury (flucloxacillin); LUSC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.29 -0.41 2.78e-15 Intelligence (multi-trait analysis); LUSC trans rs10506458 1.000 rs12425932 chr12:63410497 C/A cg22491629 chr6:157744540 C6orf35 -0.85 -10.38 -0.49 4.48e-22 Hemostatic factors and hematological phenotypes; LUSC trans rs2197308 0.765 rs117216293 chr12:37882982 T/C cg06521331 chr12:34319734 NA 0.4 6.24 0.32 1.36e-9 Morning vs. evening chronotype; LUSC cis rs17021463 0.966 rs10856908 chr4:95222755 G/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.42 -0.42 1.15e-15 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.86 -0.35 3.41e-11 Lung cancer; LUSC cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg21535247 chr6:8435926 SLC35B3 0.56 8.81 0.43 7.17e-17 Motion sickness; LUSC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg20821713 chr7:1055600 C7orf50 -0.49 -6.56 -0.34 2.01e-10 Bronchopulmonary dysplasia; LUSC cis rs10465746 0.780 rs11163862 chr1:84355418 A/T cg10977910 chr1:84465055 TTLL7 -0.48 -6.88 -0.35 2.9100000000000002e-11 Obesity-related traits; LUSC cis rs4072705 0.646 rs915032 chr9:127245682 G/C cg13476313 chr9:127244764 NR5A1 0.33 6.36 0.33 6.81e-10 Menarche (age at onset); LUSC cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.93 0.4 3.39e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21582582 chr3:182698605 DCUN1D1 -0.46 -8.13 -0.41 8.35e-15 Intelligence (multi-trait analysis); LUSC trans rs3733585 0.578 rs4466042 chr4:9955367 T/C cg26043149 chr18:55253948 FECH -0.45 -6.92 -0.35 2.27e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs79149102 0.579 rs28394281 chr15:75326754 C/G cg17294928 chr15:75287854 SCAMP5 -0.71 -6.45 -0.33 3.89e-10 Lung cancer; LUSC trans rs561341 0.505 rs28708703 chr17:30386845 C/G cg20587970 chr11:113659929 NA -1.19 -16.26 -0.66 3.23e-44 Hip circumference adjusted for BMI; LUSC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg00012203 chr2:219082015 ARPC2 0.68 11.08 0.52 1.64e-24 Colorectal cancer; LUSC cis rs7586879 0.639 rs7567997 chr2:25096952 A/G cg01884057 chr2:25150051 NA 0.42 9.71 0.47 8.31e-20 Body mass index; LUSC cis rs6558174 0.863 rs17746902 chr8:22491980 A/C cg03733263 chr8:22462867 KIAA1967 -0.46 -6.44 -0.33 4.08e-10 Breast cancer; LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.89 0.35 2.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7572644 0.656 rs4666018 chr2:28042059 C/T cg27432699 chr2:27873401 GPN1 0.58 7.36 0.37 1.47e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1865760 0.928 rs9295673 chr6:25912094 T/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.99 0.36 1.49e-11 Height; LUSC cis rs3916 0.955 rs35771722 chr12:121154000 A/G cg27246729 chr12:121163418 ACADS 0.5 7.25 0.37 2.99e-12 Urinary metabolites (H-NMR features); LUSC cis rs2040771 0.770 rs9605962 chr22:19233615 C/T cg02655711 chr22:19163373 SLC25A1 0.47 8.41 0.42 1.23e-15 Metabolite levels (small molecules and protein measures); LUSC cis rs6964587 0.610 rs10953056 chr7:91466700 C/T cg17063962 chr7:91808500 NA 0.54 8.7 0.43 1.49e-16 Breast cancer; LUSC cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg23711669 chr6:146136114 FBXO30 0.92 17.68 0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs6681460 0.546 rs1359462 chr1:67169201 C/A cg02459107 chr1:67143332 SGIP1 0.34 5.98 0.31 5.75e-9 Presence of antiphospholipid antibodies; LUSC cis rs681343 1.000 rs679574 chr19:49206108 C/G cg21064579 chr19:49206444 FUT2 0.44 8.44 0.42 9.61e-16 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; LUSC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.86 -10.96 -0.51 4.35e-24 Gut microbiome composition (summer); LUSC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg26441486 chr22:50317300 CRELD2 0.5 7.66 0.39 2.08e-13 Schizophrenia; LUSC cis rs3020736 0.500 rs8143153 chr22:42515637 G/C cg04733989 chr22:42467013 NAGA -0.62 -9.72 -0.47 7.81e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.38 0.62 8.18e-37 Platelet count; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg27275115 chr18:10526342 NAPG 0.46 6.74 0.35 7.09e-11 Risky sexual behaviors in alcohol dependence; LUSC cis rs7173743 0.935 rs12232282 chr15:79136525 T/C cg00540400 chr15:79124168 NA -0.33 -5.74 -0.3 2.12e-8 Coronary artery disease; LUSC cis rs35063026 1.000 rs35063026 chr16:89736157 C/T cg07984980 chr16:89898383 SPIRE2 0.92 7.63 0.39 2.46e-13 Facial pigmentation;Squamous cell carcinoma; LUSC cis rs9303280 0.587 rs35123741 chr17:38092930 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.36 -5.91 -0.31 8.22e-9 Self-reported allergy; LUSC cis rs1881396 0.783 rs10181342 chr2:27757343 A/G cg27432699 chr2:27873401 GPN1 0.67 9.19 0.45 4.39e-18 Nonalcoholic fatty liver disease; LUSC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg26380479 chr7:97908229 NA -0.27 -6.14 -0.32 2.28e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs800082 0.516 rs1178895 chr3:144240563 G/T cg24215973 chr2:240111563 HDAC4 0.44 6.81 0.35 4.59e-11 Smoking behavior; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.91 -0.51 6.79e-24 Alzheimer's disease; LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.44 0.62 4.62e-37 Platelet count; LUSC cis rs12912251 0.947 rs7165988 chr15:38988815 C/G cg01338139 chr15:38987640 C15orf53 -0.5 -6.83 -0.35 3.95e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs12928939 0.769 rs1056303 chr16:71670066 C/T cg08717414 chr16:71523259 ZNF19 -0.41 -5.8 -0.3 1.52e-8 Post bronchodilator FEV1; LUSC cis rs354225 0.539 rs10175967 chr2:54931457 T/C cg26097391 chr2:54893211 SPTBN1 0.46 6.1 0.32 2.95e-9 Schizophrenia; LUSC cis rs7178572 1.000 rs1565756 chr15:77741640 G/A cg22256960 chr15:77711686 NA -0.54 -9.13 -0.45 6.77e-18 Type 2 diabetes; LUSC cis rs4969178 0.965 rs56658017 chr17:76396164 G/A cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg24531977 chr5:56204891 C5orf35 -0.89 -13.72 -0.6 2.83e-34 Initial pursuit acceleration; LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg08859206 chr1:53392774 SCP2 -0.52 -8.87 -0.44 4.52e-17 Monocyte count; LUSC cis rs7267979 0.899 rs6115213 chr20:25550372 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 17.46 0.69 5.73e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4474465 0.790 rs10899541 chr11:78245573 A/G cg27205649 chr11:78285834 NARS2 -0.48 -5.77 -0.3 1.82e-8 Alzheimer's disease (survival time); LUSC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg05425664 chr17:57184151 TRIM37 -0.56 -8.28 -0.41 2.93e-15 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.42 -0.46 7.58e-19 Gut microbiome composition (summer); LUSC cis rs62103177 0.525 rs4799116 chr18:77736735 A/G cg20368463 chr18:77673604 PQLC1 -0.63 -6.89 -0.35 2.76e-11 Opioid sensitivity; LUSC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg18352616 chr4:3374830 RGS12 0.31 6.26 0.32 1.16e-9 Serum sulfate level; LUSC cis rs1949733 0.523 rs16842557 chr4:8543985 C/T cg11789530 chr4:8429930 ACOX3 -0.41 -5.95 -0.31 6.71e-9 Response to antineoplastic agents; LUSC cis rs240764 0.680 rs12209777 chr6:101156639 G/A cg09795085 chr6:101329169 ASCC3 -0.41 -5.88 -0.31 1e-8 Neuroticism; LUSC cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg10820045 chr2:198174542 NA -0.33 -6.06 -0.31 3.73e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs7208859 0.623 rs7219712 chr17:29080570 G/T cg13385521 chr17:29058706 SUZ12P 0.7 6.91 0.35 2.44e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.47 -7.27 -0.37 2.53e-12 Insulin-like growth factors; LUSC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg03806693 chr22:41940476 POLR3H 0.99 14.24 0.61 2.63e-36 Vitiligo; LUSC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.6 0.46 2.01e-19 Mean platelet volume; LUSC cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg12219531 chr12:120966889 COQ5 -0.58 -7.85 -0.39 5.86e-14 High light scatter reticulocyte count; LUSC cis rs7000551 0.751 rs2449340 chr8:22389900 T/G cg12081754 chr8:22256438 SLC39A14 0.47 7.04 0.36 1.11e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg01689657 chr7:91764605 CYP51A1 0.32 5.76 0.3 1.89e-8 Breast cancer; LUSC trans rs7819412 0.521 rs9329238 chr8:11033737 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -7.32 -0.37 1.9e-12 Triglycerides; LUSC cis rs68170813 0.559 rs4730223 chr7:106814234 A/T cg02696742 chr7:106810147 HBP1 0.65 9.89 0.48 2.08e-20 Coronary artery disease; LUSC cis rs2820315 0.867 rs2819348 chr1:201884952 T/C cg10061532 chr1:201886748 LMOD1 0.29 6.78 0.35 5.37e-11 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs4780401 0.609 rs8063099 chr16:11806714 T/G cg01061890 chr16:11836724 TXNDC11 -0.56 -8.63 -0.43 2.52e-16 Rheumatoid arthritis; LUSC cis rs977987 0.806 rs11642572 chr16:75452782 C/T cg03315344 chr16:75512273 CHST6 0.49 9.1 0.45 8.63e-18 Dupuytren's disease; LUSC cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg21770322 chr7:97807741 LMTK2 -0.48 -8.43 -0.42 1.03e-15 Breast cancer; LUSC cis rs2070433 0.500 rs9306156 chr21:47960493 T/C cg12379764 chr21:47803548 PCNT 0.72 10.93 0.51 5.73e-24 Lymphocyte counts; LUSC trans rs61931739 0.591 rs4931764 chr12:33979423 A/G cg13010199 chr12:38710504 ALG10B 0.39 5.98 0.31 5.79e-9 Morning vs. evening chronotype; LUSC trans rs7615952 0.551 rs12695470 chr3:125635718 C/A cg07211511 chr3:129823064 LOC729375 -1.24 -18.99 -0.72 4.75e-55 Blood pressure (smoking interaction); LUSC cis rs78707713 0.535 rs3812705 chr10:71211146 A/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.46 -0.46 5.56e-19 Venous thromboembolism; LUSC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg01802117 chr1:53393560 SCP2 0.38 6.32 0.33 8.48e-10 Monocyte count; LUSC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.46e-12 Motion sickness; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg05552183 chr6:42928497 GNMT 0.49 8.17 0.41 6.42e-15 Plasma homocysteine levels (post-methionine load test); LUSC cis rs6960043 1.000 rs6980437 chr7:15054916 T/G cg19272540 chr7:15055459 NA -0.33 -8.04 -0.4 1.63e-14 Type 2 diabetes; LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.51 0.65 3.1e-41 Platelet count; LUSC cis rs7264396 0.790 rs2295355 chr20:34252654 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.82 -0.47 3.7e-20 Total cholesterol levels; LUSC cis rs6964587 1.000 rs12531366 chr7:91683849 C/G cg22117172 chr7:91764530 CYP51A1 0.32 5.8 0.3 1.51e-8 Breast cancer; LUSC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 1.000 rs689826 chr15:43749916 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.95 11.05 0.52 2.15e-24 Lung cancer in ever smokers; LUSC trans rs13424581 1.000 rs7589474 chr2:225727431 C/T cg12623045 chr10:135067449 NA -0.47 -6.08 -0.32 3.25e-9 Platelet distribution width; LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg18404041 chr3:52824283 ITIH1 -0.56 -10.64 -0.5 5.73e-23 Bipolar disorder; LUSC cis rs7267979 1.000 rs1888998 chr20:25291826 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.51 -0.34 2.68e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs7824557 0.564 rs12550129 chr8:11233917 C/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.73 -0.3 2.25e-8 Retinal vascular caliber; LUSC cis rs2835872 0.965 rs73222314 chr21:39014802 A/G cg20424643 chr21:39039972 KCNJ6 0.43 6.52 0.34 2.67e-10 Electroencephalographic traits in alcoholism; LUSC cis rs4285028 0.948 rs34696871 chr3:121671880 T/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.81 -0.47 4e-20 Multiple sclerosis; LUSC cis rs7100689 0.622 rs10887798 chr10:82131613 G/A cg00277334 chr10:82204260 NA -0.52 -7.69 -0.39 1.65e-13 Post bronchodilator FEV1; LUSC cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC trans rs7939886 0.764 rs11227350 chr11:55912289 T/C cg03929089 chr4:120376271 NA 0.77 6.09 0.32 3.03e-9 Myopia (pathological); LUSC cis rs677665 0.537 rs72641831 chr1:9335173 G/T cg25755851 chr1:9335794 NA 0.8 12.78 0.57 1.02e-30 Eosinophil percentage of white cells; LUSC cis rs4474465 0.850 rs7112872 chr11:78227396 C/A cg27205649 chr11:78285834 NARS2 0.5 5.75 0.3 2.03e-8 Alzheimer's disease (survival time); LUSC trans rs2197308 0.667 rs61920838 chr12:37856814 T/C cg06521331 chr12:34319734 NA 0.41 6.5 0.34 2.93e-10 Morning vs. evening chronotype; LUSC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg21385522 chr1:16154831 NA 0.7 10.51 0.5 1.6400000000000001e-22 Dilated cardiomyopathy; LUSC cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.35 2.06e-11 Monocyte percentage of white cells; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg00417297 chr3:40518742 ZNF619 0.41 6.32 0.33 8.19e-10 Schizophrenia; LUSC cis rs7572733 0.514 rs700686 chr2:198721054 G/A cg00792783 chr2:198669748 PLCL1 0.43 5.86 0.31 1.12e-8 Dermatomyositis; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg07167872 chr1:205819463 PM20D1 0.88 17.16 0.68 9.06e-48 Menarche (age at onset); LUSC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 10.06 0.48 5.6e-21 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg16850897 chr7:100343110 ZAN -0.61 -8.09 -0.4 1.12e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11214589 0.905 rs10891539 chr11:113236492 G/C cg14159747 chr11:113255604 NA 0.28 7.1 0.36 7.74e-12 Neuroticism; LUSC cis rs72781680 0.898 rs72781639 chr2:24204148 C/G cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg15065069 chr1:154974120 ZBTB7B -0.46 -7.0 -0.36 1.39e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg03709012 chr19:19516395 GATAD2A 0.74 11.3 0.53 2.7e-25 Tonsillectomy; LUSC cis rs9650315 0.866 rs13275320 chr8:57193032 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.39 0.33 5.64e-10 Height; LUSC cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg03146154 chr1:46216737 IPP -0.55 -8.08 -0.4 1.22e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs897984 0.609 rs732172 chr16:31050033 C/T cg02466173 chr16:30829666 NA -0.54 -10.37 -0.49 5.05e-22 Dementia with Lewy bodies; LUSC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg15448220 chr1:150897856 SETDB1 0.42 6.02 0.31 4.48e-9 Melanoma; LUSC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.29 0.33 1.02e-9 Menopause (age at onset); LUSC cis rs922692 1.000 rs12901913 chr15:78981348 C/T cg00540400 chr15:79124168 NA -0.34 -5.67 -0.3 3.13e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7208859 0.623 rs8067035 chr17:29102188 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.73 0.35 7.58e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7659604 0.728 rs6852923 chr4:122688324 G/A cg20573242 chr4:122745356 CCNA2 0.52 7.62 0.38 2.67e-13 Type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01538984 chr7:140396422 LOC100134713;NDUFB2 0.46 6.55 0.34 2.14e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg18301423 chr5:131593218 PDLIM4 0.38 6.19 0.32 1.74e-9 Blood metabolite levels; LUSC cis rs4930103 0.904 rs59121562 chr11:2025034 A/T cg23202291 chr11:1979235 NA 0.38 5.92 0.31 8.08e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg23172400 chr8:95962367 TP53INP1 -0.34 -6.39 -0.33 5.44e-10 Type 2 diabetes; LUSC cis rs6138458 0.626 rs6138473 chr20:25012155 A/G cg26195577 chr20:24973756 C20orf3 -0.77 -11.84 -0.54 3.05e-27 Blood protein levels; LUSC cis rs9815354 0.767 rs17280980 chr3:41810949 A/T cg03022575 chr3:42003672 ULK4 0.85 8.65 0.43 2.23e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4380275 0.782 rs4335978 chr2:750078 A/G cg21665850 chr2:731073 NA 0.34 5.66 0.3 3.3e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs6867032 0.527 rs4246752 chr5:1975575 T/A cg26168224 chr5:2018326 NA -0.54 -7.53 -0.38 4.79e-13 Gut microbiome composition (winter); LUSC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg15445000 chr17:37608096 MED1 0.39 6.71 0.34 8.49e-11 Glomerular filtration rate (creatinine); LUSC cis rs17253792 0.822 rs78826571 chr14:56048906 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs1577917 0.958 rs12196377 chr6:86566775 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.77 -0.43 9.17e-17 Response to antipsychotic treatment; LUSC cis rs12137294 0.866 rs896320 chr1:205205347 T/C cg21643547 chr1:205240462 TMCC2 -0.36 -6.46 -0.33 3.74e-10 Red cell distribution width; LUSC cis rs3820068 0.705 rs4646109 chr1:15817319 T/C cg17385448 chr1:15911702 AGMAT 0.38 5.83 0.3 1.29e-8 Systolic blood pressure; LUSC cis rs897984 0.520 rs4889614 chr16:30862135 G/A cg02466173 chr16:30829666 NA 0.55 9.26 0.45 2.55e-18 Dementia with Lewy bodies; LUSC cis rs6688613 0.685 rs10918599 chr1:166918786 T/C cg07049167 chr1:166818506 POGK 0.41 5.85 0.3 1.18e-8 Refractive astigmatism; LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg08677398 chr8:58056175 NA 0.53 7.1 0.36 7.61e-12 Developmental language disorder (linguistic errors); LUSC cis rs1028488 0.535 rs9460109 chr6:170618195 C/T cg20370364 chr6:170703943 FAM120B -0.51 -7.88 -0.4 4.54e-14 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.96 0.36 1.81e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg01528321 chr10:82214614 TSPAN14 0.62 8.94 0.44 2.67e-17 Post bronchodilator FEV1; LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg01125463 chr6:42946178 PEX6 -0.36 -5.96 -0.31 6.4e-9 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg19717773 chr7:2847554 GNA12 -0.41 -6.45 -0.33 3.87e-10 Height; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.47 6.16 0.32 2.12e-9 Renal function-related traits (BUN); LUSC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg08677398 chr8:58056175 NA 0.52 6.33 0.33 7.78e-10 Developmental language disorder (linguistic errors); LUSC cis rs2109514 0.967 rs4730743 chr7:116145957 A/T cg12739419 chr7:116140593 CAV2 -0.28 -6.3 -0.33 9.46e-10 Prevalent atrial fibrillation; LUSC cis rs17094222 0.504 rs4917904 chr10:102447292 G/A cg04918978 chr10:102441148 NA -0.39 -5.65 -0.3 3.53e-8 Body mass index;BMI (adjusted for smoking behaviour);Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg24110177 chr3:50126178 RBM5 0.65 11.68 0.54 1.14e-26 Body mass index; LUSC cis rs1185460 0.565 rs1182922 chr11:118932859 G/A cg01677386 chr11:118938358 VPS11 0.41 5.74 0.3 2.15e-8 Coronary artery disease; LUSC cis rs9326248 0.581 rs6589590 chr11:116936081 A/C cg01368799 chr11:117014884 PAFAH1B2 0.61 9.31 0.45 1.77e-18 Blood protein levels; LUSC cis rs354225 0.544 rs3796019 chr2:54807279 G/A cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg12386194 chr3:101231763 SENP7 -0.52 -7.3 -0.37 2.08e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg11663144 chr21:46675770 NA -0.38 -6.62 -0.34 1.43e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6960043 0.620 rs11760782 chr7:15064788 A/T cg19272540 chr7:15055459 NA 0.34 7.9 0.4 4.17e-14 Type 2 diabetes; LUSC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg06484146 chr7:12443880 VWDE -0.69 -7.35 -0.37 1.53e-12 Coronary artery disease; LUSC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg14895029 chr7:2775587 GNA12 -0.4 -6.07 -0.32 3.38e-9 Height; LUSC trans rs11949289 0.935 rs61390992 chr5:28336243 T/C cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.44e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6496044 1.000 rs6496044 chr15:86067306 G/A cg13263323 chr15:86062960 AKAP13 -0.37 -5.88 -0.31 9.99e-9 Interstitial lung disease; LUSC cis rs7598759 0.679 rs6437018 chr2:232327691 A/C cg19187155 chr2:232395269 NMUR1 0.49 7.16 0.36 5.16e-12 Noise-induced hearing loss; LUSC cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg00012203 chr2:219082015 ARPC2 0.81 14.41 0.62 6.1e-37 Colorectal cancer; LUSC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.48 7.83 0.39 6.52e-14 Vitiligo; LUSC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg11645453 chr3:52864694 ITIH4 0.34 8.09 0.4 1.13e-14 Bipolar disorder; LUSC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg16797656 chr11:68205561 LRP5 -0.4 -7.26 -0.37 2.7e-12 Total body bone mineral density; LUSC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg19318889 chr4:1322082 MAEA 0.45 7.28 0.37 2.42e-12 Obesity-related traits; LUSC cis rs8060686 0.545 rs11043 chr16:68262958 G/A cg05110241 chr16:68378359 PRMT7 -0.6 -6.75 -0.35 6.37e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs7586879 0.964 rs11688665 chr2:25121168 G/T cg04586622 chr2:25135609 ADCY3 0.32 6.17 0.32 1.94e-9 Body mass index; LUSC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg09034736 chr1:150693464 HORMAD1 0.49 7.15 0.36 5.43e-12 Tonsillectomy; LUSC cis rs9467773 0.595 rs3799379 chr6:26404694 C/T cg05738196 chr6:26577821 NA -0.49 -7.01 -0.36 1.34e-11 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.68 10.76 0.51 2.15e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11098499 0.820 rs13122709 chr4:120555356 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.37 0.33 6.34e-10 Corneal astigmatism; LUSC cis rs77216612 0.877 rs7956514 chr12:12879254 T/G cg04607235 chr12:12878440 APOLD1 -0.95 -15.54 -0.65 2.25e-41 Lymphocyte counts; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg27094323 chr7:1216898 NA -0.44 -7.57 -0.38 3.79e-13 Longevity;Endometriosis; LUSC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg23625390 chr15:77176239 SCAPER 0.46 7.02 0.36 1.23e-11 Blood metabolite levels; LUSC cis rs7659604 1.000 rs73844281 chr4:122664688 A/G cg06713675 chr4:122721982 EXOSC9 -0.45 -8.02 -0.4 1.86e-14 Type 2 diabetes; LUSC cis rs28785552 0.800 rs10853854 chr19:53232128 A/G cg22067481 chr19:53234126 ZNF611 0.51 7.16 0.36 5.18e-12 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg05347473 chr6:146136440 FBXO30 0.53 9.07 0.44 1.08e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs1178968 0.901 rs1178970 chr7:72750345 G/A cg25889504 chr7:72793014 NA 0.59 7.91 0.4 3.86e-14 Triglyceride levels; LUSC cis rs870825 0.860 rs62339895 chr4:185598681 A/G cg04058563 chr4:185651563 MLF1IP -0.82 -12.3 -0.56 6.24e-29 Blood protein levels; LUSC cis rs17401966 0.798 rs12408435 chr1:10323342 T/A cg19773385 chr1:10388646 KIF1B -0.55 -8.72 -0.43 1.36e-16 Hepatocellular carcinoma; LUSC cis rs983392 0.868 rs7926954 chr11:59932579 G/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.8 -0.3 1.55e-8 Alzheimer's disease (late onset); LUSC cis rs9354352 1.000 rs9354352 chr6:66696272 T/C cg07460842 chr6:66804631 NA 0.68 9.95 0.48 1.33e-20 Initial pursuit acceleration in psychotic disorders; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg05896524 chr21:47604654 C21orf56 0.51 7.79 0.39 8.28e-14 Testicular germ cell tumor; LUSC cis rs3820928 0.839 rs58580037 chr2:227876274 G/T cg11843606 chr2:227700838 RHBDD1 -0.55 -7.93 -0.4 3.36e-14 Pulmonary function; LUSC cis rs981844 0.712 rs11099915 chr4:154743624 A/G cg14289246 chr4:154710475 SFRP2 -0.44 -6.11 -0.32 2.82e-9 Response to statins (LDL cholesterol change); LUSC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg12432903 chr7:1882776 MAD1L1 0.51 6.25 0.32 1.23e-9 Bipolar disorder; LUSC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg18876405 chr7:65276391 NA -0.58 -9.46 -0.46 5.77e-19 Aortic root size; LUSC cis rs5758511 0.514 rs5758586 chr22:42517471 A/T cg00645731 chr22:42541494 CYP2D7P1 0.6 10.05 0.48 6.31e-21 Birth weight; LUSC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg12463550 chr7:65579703 CRCP 0.44 6.5 0.33 3.01e-10 Aortic root size; LUSC cis rs6500602 0.610 rs1659499 chr16:4595269 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.47 -6.32 -0.33 8.59e-10 Schizophrenia; LUSC cis rs240110 0.539 rs6919745 chr6:101338978 T/C cg09795085 chr6:101329169 ASCC3 0.48 7.12 0.36 6.82e-12 Neuroticism; LUSC cis rs344364 0.511 rs2917515 chr16:1945271 G/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.62 -6.43 -0.33 4.33e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg06022373 chr22:39101656 GTPBP1 0.84 13.32 0.59 8.97e-33 Menopause (age at onset); LUSC cis rs6700896 0.931 rs12034502 chr1:66099831 C/T cg04111102 chr1:66153794 NA 0.32 7.08 0.36 8.57e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg18402987 chr7:1209562 NA 0.62 7.25 0.37 2.94e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg05234568 chr11:5960015 NA 0.58 9.91 0.48 1.8899999999999998e-20 DNA methylation (variation); LUSC cis rs9287719 0.870 rs10167676 chr2:10753140 G/A cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg23158103 chr7:148848205 ZNF398 -0.46 -6.8 -0.35 4.82e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2760061 0.846 rs3094912 chr1:228209815 T/A cg04850211 chr1:228464232 OBSCN -0.32 -5.81 -0.3 1.43e-8 Diastolic blood pressure; LUSC cis rs9420 0.961 rs2847308 chr11:57498232 C/T cg02958346 chr11:57425731 CLP1 0.42 6.12 0.32 2.64e-9 Schizophrenia; LUSC cis rs2760061 0.583 rs3094911 chr1:228210179 A/G cg02753203 chr1:228287806 NA 0.97 19.37 0.73 1.45e-56 Diastolic blood pressure; LUSC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.45 7.08 0.36 8.72e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9325144 0.647 rs34963631 chr12:38912260 T/A cg26384229 chr12:38710491 ALG10B -0.6 -9.19 -0.45 4.36e-18 Morning vs. evening chronotype; LUSC cis rs977987 0.806 rs1544810 chr16:75411163 A/T cg04384234 chr16:75411784 CFDP1 -0.42 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs7917772 0.582 rs10883736 chr10:104320029 G/T cg22532475 chr10:104410764 TRIM8 -0.26 -6.12 -0.32 2.61e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg01657329 chr11:68192670 LRP5 -0.42 -6.3 -0.33 9.42e-10 Total body bone mineral density; LUSC cis rs1670533 1.000 rs6852850 chr4:1052857 C/G cg02018176 chr4:1364513 KIAA1530 0.44 6.17 0.32 1.95e-9 Recombination rate (females); LUSC cis rs9807841 0.617 rs892087 chr19:10794793 C/T cg17710535 chr19:10819994 QTRT1 0.42 6.91 0.35 2.51e-11 Inflammatory skin disease; LUSC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 10.13 0.48 3.21e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg03526776 chr6:41159608 TREML2 0.33 6.19 0.32 1.74e-9 Alzheimer's disease (late onset); LUSC trans rs61931739 0.517 rs1197562 chr12:34122037 G/A cg26384229 chr12:38710491 ALG10B 0.68 10.61 0.5 7.34e-23 Morning vs. evening chronotype; LUSC cis rs2835872 0.828 rs702858 chr21:38995169 A/G cg20424643 chr21:39039972 KCNJ6 -0.38 -5.94 -0.31 7.07e-9 Electroencephalographic traits in alcoholism; LUSC cis rs12618769 0.625 rs3769717 chr2:99124817 G/A cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg24642844 chr7:1081250 C7orf50 -0.71 -10.09 -0.48 4.57e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg08888203 chr3:10149979 C3orf24 -0.59 -8.33 -0.41 2.15e-15 Alzheimer's disease; LUSC cis rs12681287 0.547 rs11992656 chr8:87534869 T/A cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs2274459 0.841 rs10456075 chr6:33681603 G/A cg06253072 chr6:33679850 C6orf125 0.48 5.82 0.3 1.39e-8 Obesity (extreme); LUSC cis rs11155671 0.530 rs4869764 chr6:150211828 T/C cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.67e-10 Testicular germ cell tumor; LUSC cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.16 0.68 8.7e-48 Chronic sinus infection; LUSC cis rs7917772 0.582 rs11191352 chr10:104372244 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.08 0.52 1.68e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 13.9 0.61 5.42e-35 Platelet count; LUSC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.13 0.36 6.18e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs11792861 0.890 rs57387569 chr9:111920392 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -7.32 -0.37 1.87e-12 Menarche (age at onset); LUSC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg14019146 chr3:50243930 SLC38A3 -0.33 -7.37 -0.37 1.31e-12 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22278056 chr19:44439434 NA 0.45 6.59 0.34 1.72e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg16132339 chr22:24313637 DDTL;DDT 0.41 6.43 0.33 4.37e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs629535 0.814 rs571682 chr8:70062793 A/G cg21567404 chr3:27674614 NA 0.96 15.28 0.64 2.49e-40 Dupuytren's disease; LUSC cis rs12594515 1.000 rs8027000 chr15:45987795 T/C cg06207120 chr15:45996521 NA 0.4 6.22 0.32 1.5e-9 Waist circumference;Weight; LUSC cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg24642439 chr20:33292090 TP53INP2 0.48 7.36 0.37 1.49e-12 Glomerular filtration rate (creatinine); LUSC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg17294928 chr15:75287854 SCAMP5 -0.76 -10.12 -0.48 3.67e-21 Blood trace element (Zn levels); LUSC cis rs35883536 0.647 rs2647325 chr1:101040195 T/C cg06223162 chr1:101003688 GPR88 0.49 9.35 0.46 1.26e-18 Monocyte count; LUSC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.76 -0.43 1.02e-16 Gut microbiome composition (summer); LUSC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg20821713 chr7:1055600 C7orf50 -0.48 -6.53 -0.34 2.46e-10 Bronchopulmonary dysplasia; LUSC cis rs35146811 0.625 rs858514 chr7:99825748 A/G cg22906224 chr7:99728672 NA -0.5 -6.95 -0.36 1.91e-11 Coronary artery disease; LUSC trans rs61931739 0.500 rs34703942 chr12:34583776 T/C cg26384229 chr12:38710491 ALG10B -0.79 -13.28 -0.59 1.33e-32 Morning vs. evening chronotype; LUSC cis rs4805272 0.512 rs4805279 chr19:29336966 A/G cg03161606 chr19:29218774 NA 0.49 5.94 0.31 7.3e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.54 -6.85 -0.35 3.59e-11 Chronic sinus infection; LUSC cis rs9650315 0.929 rs6987156 chr8:57169465 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs9303401 0.614 rs62084384 chr17:57126842 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.02 0.58 1.31e-31 Cognitive test performance; LUSC cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg26384229 chr12:38710491 ALG10B -0.84 -15.73 -0.65 4.07e-42 Heart rate; LUSC cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg22709100 chr7:91322751 NA 0.41 5.91 0.31 8.64e-9 Breast cancer; LUSC cis rs3540 0.553 rs8042861 chr15:90977333 G/T cg10434728 chr15:90938212 IQGAP1 0.37 7.89 0.4 4.44e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs9837602 1.000 rs6802422 chr3:99778655 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 5.67 0.3 3.17e-8 Breast cancer; LUSC cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg26384229 chr12:38710491 ALG10B 0.88 15.23 0.64 3.86e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs637571 0.544 rs56239996 chr11:65730003 A/T cg17712092 chr4:129076599 LARP1B 0.81 12.19 0.55 1.59e-28 Eosinophil percentage of white cells; LUSC cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.82 11.57 0.53 3.03e-26 Chronic sinus infection; LUSC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.8 0.35 4.92e-11 Intelligence (multi-trait analysis); LUSC cis rs2235649 0.552 rs7203361 chr16:1963085 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.45 -5.75 -0.3 2e-8 Blood metabolite levels; LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg22166914 chr1:53195759 ZYG11B 0.56 9.13 0.45 6.88e-18 Monocyte count; LUSC cis rs4604732 0.578 rs79203328 chr1:247626581 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.07 0.32 3.56e-9 Lymphocyte counts; LUSC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg23711669 chr6:146136114 FBXO30 -0.9 -17.01 -0.68 3.67e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs28647808 0.881 rs7029386 chr9:136263736 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs11676348 0.901 rs7562334 chr2:219003360 G/A cg00012203 chr2:219082015 ARPC2 -0.54 -8.51 -0.42 5.99e-16 Ulcerative colitis; LUSC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg21248554 chr2:27665150 KRTCAP3 -0.32 -6.26 -0.32 1.16e-9 Total body bone mineral density; LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.26e-25 Gut microbiome composition (summer); LUSC cis rs5758659 0.652 rs133340 chr22:42417687 A/T cg04733989 chr22:42467013 NAGA -0.38 -6.41 -0.33 5.02e-10 Cognitive function; LUSC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.13 0.55 2.54e-28 Cognitive test performance; LUSC cis rs7647973 0.925 rs7429661 chr3:49228800 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 6.78 0.35 5.49e-11 Menarche (age at onset); LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg14789911 chr21:47582049 C21orf56 -0.37 -5.65 -0.3 3.38e-8 Testicular germ cell tumor; LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg01802117 chr1:53393560 SCP2 -0.39 -6.52 -0.34 2.55e-10 Monocyte count; LUSC cis rs1506636 0.886 rs4731112 chr7:123269118 C/G cg03229431 chr7:123269106 ASB15 -0.7 -11.73 -0.54 7.66e-27 Plateletcrit;Platelet count; LUSC cis rs2289583 0.642 rs8034281 chr15:75384227 A/G cg14664628 chr15:75095509 CSK -0.45 -6.49 -0.33 3.02e-10 Systemic lupus erythematosus; LUSC cis rs3768617 0.510 rs3768622 chr1:183090011 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.0 0.52 3.3e-24 Fuchs's corneal dystrophy; LUSC trans rs9650657 0.571 rs11783247 chr8:10788875 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.17 -0.41 6.28e-15 Neuroticism; LUSC trans rs7615952 0.932 rs9841157 chr3:125635655 C/A cg07211511 chr3:129823064 LOC729375 -1.24 -18.99 -0.72 4.75e-55 Blood pressure (smoking interaction); LUSC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg18479299 chr3:125709523 NA -0.51 -5.87 -0.31 1.05e-8 Blood pressure (smoking interaction); LUSC cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.56e-13 Motion sickness; LUSC cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg17892150 chr10:133769511 PPP2R2D -0.67 -9.27 -0.45 2.34e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs3768617 0.811 rs61808068 chr1:182979377 T/A ch.1.3577855R chr1:183094577 LAMC1 0.59 8.42 0.42 1.12e-15 Fuchs's corneal dystrophy; LUSC cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg26597838 chr10:835615 NA 0.64 8.08 0.4 1.21e-14 Eosinophil percentage of granulocytes; LUSC cis rs10170846 0.893 rs12614976 chr2:223542896 A/T cg25565276 chr2:223520875 FARSB 0.62 9.38 0.46 1.02e-18 Schizophrenia (inflammation and infection response interaction); LUSC cis rs75804782 0.521 rs72982598 chr2:239455052 G/A cg18131467 chr2:239335373 ASB1 -0.63 -6.01 -0.31 4.74e-9 Morning vs. evening chronotype;Chronotype; LUSC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -8.15 -0.41 7.42e-15 Blood pressure (smoking interaction); LUSC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg20203395 chr5:56204925 C5orf35 -0.44 -6.45 -0.33 4e-10 Coronary artery disease; LUSC cis rs9326248 0.559 rs1269329 chr11:116755041 T/C cg20608306 chr11:116969690 SIK3 0.37 6.92 0.35 2.32e-11 Blood protein levels; LUSC cis rs57994353 0.566 rs10870160 chr9:139312996 C/T cg14019695 chr9:139328340 INPP5E 0.36 5.67 0.3 3.1e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; LUSC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.534 rs11052991 chr12:34059018 G/T cg13010199 chr12:38710504 ALG10B -0.49 -7.5 -0.38 5.88e-13 Morning vs. evening chronotype; LUSC cis rs12458462 0.892 rs2242175 chr18:77464406 G/A cg20476159 chr18:77451067 CTDP1 -0.32 -5.74 -0.3 2.15e-8 Monocyte count; LUSC trans rs8072100 0.967 rs4794001 chr17:45720849 T/C cg04995722 chr7:26192034 NFE2L3 -0.38 -6.35 -0.33 7.18e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12618769 1.000 rs72825719 chr2:99247465 C/T cg10123293 chr2:99228465 UNC50 0.43 5.89 0.31 9.65e-9 Bipolar disorder; LUSC cis rs847577 0.609 rs6465657 chr7:97816327 C/T cg24562669 chr7:97807699 LMTK2 0.48 8.56 0.42 4.18e-16 Breast cancer; LUSC cis rs3020736 0.500 rs2839708 chr22:42500745 A/G cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC trans rs1493916 0.837 rs9945976 chr18:31409314 C/T cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs644799 0.562 rs1254989 chr11:95508121 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.68 10.33 0.49 7.13e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.5 -6.84 -0.35 3.88e-11 Mean platelet volume; LUSC cis rs6977660 1.000 rs12673970 chr7:19813018 T/C cg05791153 chr7:19748676 TWISTNB 0.55 6.14 0.32 2.31e-9 Thyroid stimulating hormone; LUSC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11644478 chr21:40555479 PSMG1 -0.67 -10.61 -0.5 7.68e-23 Menarche (age at onset); LUSC cis rs4951018 0.821 rs7529037 chr1:205637501 C/G cg26354017 chr1:205819088 PM20D1 -0.39 -5.68 -0.3 2.98e-8 Prostate-specific antigen levels; LUSC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.53 -0.34 2.45e-10 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.62e-9 Monocyte count; LUSC cis rs3862435 0.518 rs2601170 chr15:90914209 C/T cg22089800 chr15:90895588 ZNF774 0.59 6.3 0.33 9.65e-10 Response to exercise (triglyceride level interaction); LUSC cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg02574844 chr11:5959923 NA -0.47 -6.75 -0.35 6.74e-11 DNA methylation (variation); LUSC trans rs561341 1.000 rs521919 chr17:30298039 G/T cg20587970 chr11:113659929 NA -1.15 -15.81 -0.65 1.98e-42 Hip circumference adjusted for BMI; LUSC cis rs6669072 0.528 rs3856226 chr1:91245109 C/T cg08895590 chr1:91227319 NA 0.29 6.14 0.32 2.28e-9 Cognitive function; LUSC cis rs7659604 0.540 rs11734075 chr4:122695685 C/T cg06713675 chr4:122721982 EXOSC9 0.38 6.11 0.32 2.78e-9 Type 2 diabetes; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg14893161 chr1:205819251 PM20D1 0.99 22.3 0.77 4.09e-68 Menarche (age at onset); LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13126279 chr21:47581558 C21orf56 -0.55 -8.49 -0.42 6.82e-16 Testicular germ cell tumor; LUSC cis rs317689 0.658 rs479971 chr12:69672471 A/G cg20891283 chr12:69753455 YEATS4 0.44 5.78 0.3 1.67e-8 Response to diuretic therapy; LUSC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg17971929 chr21:40555470 PSMG1 0.77 13.25 0.59 1.65e-32 Cognitive function; LUSC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg09365446 chr1:150670422 GOLPH3L 0.46 6.74 0.35 7.09e-11 Melanoma; LUSC cis rs9527 0.568 rs12772775 chr10:104702999 C/A cg05855489 chr10:104503620 C10orf26 0.52 7.96 0.4 2.64e-14 Arsenic metabolism; LUSC cis rs35995292 0.534 rs13228087 chr7:38909204 A/C cg19327137 chr7:38886074 VPS41 0.53 10.02 0.48 7.82e-21 Subjective well-being (multi-trait analysis); LUSC cis rs7605827 0.893 rs1024871 chr2:15626162 C/T cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs427394 0.632 rs2279656 chr5:6737576 G/A cg10857441 chr5:6722123 POLS -0.44 -8.05 -0.4 1.45e-14 Menopause (age at onset); LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg19318889 chr4:1322082 MAEA -0.54 -8.89 -0.44 3.92e-17 Obesity-related traits; LUSC cis rs17818399 0.547 rs62134736 chr2:46766446 G/A cg21681030 chr2:46777652 RHOQ 0.49 6.77 0.35 5.74e-11 Height; LUSC cis rs4911259 0.552 rs11697394 chr20:31460076 G/A cg13636640 chr20:31349939 DNMT3B -0.81 -15.5 -0.65 3.37e-41 Inflammatory bowel disease; LUSC cis rs9467773 1.000 rs6924838 chr6:26571756 C/T cg11502198 chr6:26597334 ABT1 0.64 10.06 0.48 5.52e-21 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2639990 1.000 rs609303 chr18:72895242 C/T cg03972071 chr18:72917163 ZADH2 0.46 5.79 0.3 1.63e-8 Vascular endothelial growth factor levels; LUSC cis rs9815354 0.812 rs17214945 chr3:41808660 A/C cg03022575 chr3:42003672 ULK4 0.8 8.84 0.44 5.75e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs1941023 0.606 rs3825020 chr11:60184191 G/A cg08716584 chr11:60157161 MS4A7 -0.56 -10.26 -0.49 1.16e-21 Congenital heart disease (maternal effect); LUSC cis rs41271951 0.512 rs12058128 chr1:151106113 C/T cg11822372 chr1:151115635 SEMA6C -0.74 -6.74 -0.35 7.15e-11 Blood protein levels; LUSC cis rs73198271 0.960 rs73198290 chr8:8616009 A/T cg01851573 chr8:8652454 MFHAS1 0.58 8.5 0.42 6.24e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6977660 0.619 rs10231972 chr7:19789354 C/G cg07541023 chr7:19748670 TWISTNB 0.59 6.77 0.35 5.76e-11 Thyroid stimulating hormone; LUSC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg06238570 chr21:40685208 BRWD1 -0.52 -8.04 -0.4 1.63e-14 Menarche (age at onset); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg04000159 chr8:54755598 ATP6V1H -0.49 -5.99 -0.31 5.39e-9 Height; LUSC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg03563238 chr19:33554763 RHPN2 -0.37 -6.19 -0.32 1.74e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3790645 1.000 rs657227 chr1:26892104 T/A cg17456097 chr1:26900765 RPS6KA1 0.42 6.07 0.32 3.44e-9 Glucose homeostasis traits; LUSC cis rs9660992 0.710 rs1668864 chr1:205248799 T/C cg21545522 chr1:205238299 TMCC2 0.5 9.36 0.46 1.21e-18 Mean corpuscular volume;Mean platelet volume; LUSC trans rs4596713 0.538 rs4421408 chr9:71760884 G/T cg25283916 chr1:242222868 NA -0.33 -6.76 -0.35 6.34e-11 Headache; LUSC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg18230493 chr5:56204884 C5orf35 -0.64 -9.91 -0.48 1.88e-20 Coronary artery disease; LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.58 -0.38 3.5e-13 Blood metabolite levels; LUSC trans rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05039488 chr6:79577232 IRAK1BP1 0.47 7.04 0.36 1.1e-11 Endometrial cancer; LUSC trans rs34421088 0.576 rs2572437 chr8:11098441 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.09 -0.36 8.16e-12 Neuroticism; LUSC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.42 -0.46 7.9e-19 Chronic sinus infection; LUSC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg15672331 chr15:85923765 AKAP13 -0.47 -6.12 -0.32 2.68e-9 Height; LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg05025164 chr4:1340916 KIAA1530 0.48 7.4 0.38 1.11e-12 Obesity-related traits; LUSC cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.67 10.18 0.49 2.21e-21 Total body bone mineral density; LUSC cis rs7712401 0.692 rs9327273 chr5:122073550 T/G cg19077854 chr5:122220652 SNX24 0.33 7.12 0.36 6.74e-12 Mean platelet volume; LUSC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg13628971 chr7:2884303 GNA12 0.47 6.56 0.34 2.08e-10 Height; LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg20887711 chr4:1340912 KIAA1530 0.45 6.74 0.35 7.15e-11 Obesity-related traits; LUSC cis rs9811920 0.809 rs6440967 chr3:99722396 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.34 -5.65 -0.3 3.39e-8 Axial length; LUSC cis rs72781680 1.000 rs12616250 chr2:24211550 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg09436375 chr6:42928200 GNMT -0.3 -6.89 -0.35 2.75e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6596100 0.500 rs12514041 chr5:132164313 C/T cg02081065 chr5:132209139 LEAP2 -0.64 -6.25 -0.32 1.26e-9 Breast cancer; LUSC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg18225595 chr11:63971243 STIP1 -0.53 -8.82 -0.43 6.51e-17 Platelet count; LUSC cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg07148914 chr20:33460835 GGT7 -0.53 -8.1 -0.41 1.05e-14 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg11764359 chr7:65958608 NA -0.58 -8.99 -0.44 1.87e-17 Aortic root size; LUSC cis rs7465272 0.500 rs7463655 chr8:143731034 G/C cg10596483 chr8:143751796 JRK 0.53 7.59 0.38 3.17e-13 Bipolar disorder and schizophrenia; LUSC cis rs10992471 0.603 rs968040 chr9:95279985 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.9 -0.35 2.68e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.98 -0.55 9.08e-28 Alzheimer's disease; LUSC cis rs12950390 0.853 rs12450733 chr17:45855404 A/G cg06532163 chr17:45867833 NA 0.34 6.34 0.33 7.6e-10 IgG glycosylation; LUSC cis rs1215050 0.791 rs2123099 chr4:98803456 A/G cg05340658 chr4:99064831 C4orf37 0.44 7.0 0.36 1.41e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg18758796 chr5:131593413 PDLIM4 -0.43 -6.8 -0.35 4.9e-11 Blood metabolite levels; LUSC cis rs1712517 0.773 rs1063461 chr10:105049105 C/G cg05636881 chr10:105038444 INA 0.39 6.44 0.33 4.15e-10 Migraine; LUSC cis rs17401966 1.000 rs3748578 chr1:10420918 A/G cg19773385 chr1:10388646 KIF1B 0.51 8.28 0.41 2.94e-15 Hepatocellular carcinoma; LUSC trans rs1997103 0.906 rs6593232 chr7:55402916 C/T cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6578985 1.000 rs868331 chr11:2136794 A/G cg25742037 chr11:2171694 INS-IGF2;IGF2 0.32 5.91 0.31 8.31e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg08975724 chr8:8085496 FLJ10661 0.51 7.41 0.38 1.02e-12 Mood instability; LUSC cis rs6933660 0.610 rs71549125 chr6:151770796 A/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.59 -8.33 -0.41 2.09e-15 Menarche (age at onset); LUSC cis rs13401104 0.796 rs10929165 chr2:237111187 C/G cg19324714 chr2:237145437 ASB18 0.43 5.79 0.3 1.6e-8 Educational attainment; LUSC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg06634786 chr22:41940651 POLR3H 0.53 6.18 0.32 1.82e-9 Vitiligo; LUSC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs28595532 0.748 rs72670248 chr4:119335536 A/C cg02775129 chr4:119771670 NA -0.76 -6.32 -0.33 8.37e-10 Cannabis dependence symptom count; LUSC cis rs1775715 0.707 rs2799019 chr10:32142850 C/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.75 0.35 6.46e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9378688 1.000 rs12661136 chr6:2227239 C/A cg12303981 chr6:2244766 GMDS -0.54 -6.34 -0.33 7.49e-10 Caudate nucleus volume; LUSC cis rs17661538 0.504 rs17662228 chr10:18440398 A/G cg03634479 chr10:18430412 CACNB2 0.66 6.43 0.33 4.49e-10 Response to antipsychotic treatment; LUSC cis rs17604090 0.628 rs875263 chr7:29711066 T/C cg19413766 chr7:29689036 LOC646762 -0.54 -7.33 -0.37 1.75e-12 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7223966 1.000 rs7222060 chr17:61868279 C/T cg00945038 chr17:61921165 SMARCD2 0.39 5.99 0.31 5.57e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg17294928 chr15:75287854 SCAMP5 -0.83 -11.27 -0.52 3.6e-25 Blood trace element (Zn levels); LUSC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg24675056 chr1:15929824 NA 0.49 8.46 0.42 8.28e-16 Systolic blood pressure; LUSC cis rs8062405 0.698 rs7188071 chr16:28917644 T/C cg05966235 chr16:28915196 ATP2A1 -0.33 -5.72 -0.3 2.39e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9549260 0.564 rs9577107 chr13:41271676 A/T cg21288729 chr13:41239152 FOXO1 0.54 8.31 0.41 2.35e-15 Red blood cell count; LUSC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg14895029 chr7:2775587 GNA12 -0.41 -6.12 -0.32 2.58e-9 Height; LUSC cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.42 -0.42 1.13e-15 Lymphocyte counts; LUSC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.38 0.46 1.07e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7845219 0.544 rs34293080 chr8:95908078 G/T cg16049864 chr8:95962084 TP53INP1 -0.42 -6.91 -0.35 2.51e-11 Type 2 diabetes; LUSC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg08027265 chr7:2291960 NA -0.37 -6.01 -0.31 4.99e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9300255 0.679 rs4759420 chr12:123794871 G/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -6.42 -0.33 4.76e-10 Neutrophil percentage of white cells; LUSC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg24110177 chr3:50126178 RBM5 0.56 9.26 0.45 2.62e-18 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg22535103 chr8:58192502 C8orf71 -0.78 -8.33 -0.41 2.18e-15 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg13939156 chr17:80058883 NA 0.33 6.37 0.33 6.12e-10 Life satisfaction; LUSC cis rs10875746 0.904 rs10875750 chr12:48545630 C/T cg13454099 chr12:49076203 C12orf41 -0.52 -6.15 -0.32 2.17e-9 Longevity (90 years and older); LUSC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.48 -0.46 4.74e-19 Chronic sinus infection; LUSC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.12 0.45 7.37e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2832077 0.943 rs2272701 chr21:30190907 C/T cg08807101 chr21:30365312 RNF160 -0.53 -6.68 -0.34 9.85e-11 Cognitive test performance; LUSC cis rs6494488 0.500 rs111793398 chr15:65079354 C/T cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs983392 0.679 rs6591559 chr11:60025565 C/T cg02771260 chr11:59836817 MS4A3 -0.4 -6.53 -0.34 2.51e-10 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg03676636 chr4:99064102 C4orf37 0.36 7.83 0.39 6.75e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs561341 0.700 rs6505266 chr17:30225813 G/A cg00745463 chr17:30367425 LRRC37B -0.45 -6.23 -0.32 1.38e-9 Hip circumference adjusted for BMI; LUSC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg13319975 chr6:146136371 FBXO30 -0.71 -11.44 -0.53 8.48e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs2985684 0.789 rs7161649 chr14:50064028 A/G cg04989706 chr14:50066350 PPIL5 -0.48 -6.32 -0.33 8.2e-10 Carotid intima media thickness; LUSC cis rs870825 0.616 rs7692104 chr4:185650895 T/G cg04058563 chr4:185651563 MLF1IP 0.83 12.71 0.57 1.82e-30 Blood protein levels; LUSC cis rs208520 0.909 rs9453672 chr6:66991431 A/G cg07460842 chr6:66804631 NA 0.92 12.01 0.55 7.39e-28 Exhaled nitric oxide output; LUSC cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs950169 0.580 rs11636189 chr15:85193554 G/A cg12863693 chr15:85201151 NMB 0.4 8.49 0.42 7e-16 Schizophrenia; LUSC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg18190219 chr22:46762943 CELSR1 -0.51 -5.79 -0.3 1.64e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs35146811 0.735 rs11767968 chr7:99790971 G/A cg22906224 chr7:99728672 NA 0.47 6.54 0.34 2.36e-10 Coronary artery disease; LUSC cis rs1847202 0.859 rs4274693 chr3:72949375 A/G cg25664220 chr3:72788482 NA -0.42 -7.75 -0.39 1.13e-13 Motion sickness; LUSC cis rs7615952 0.551 rs12695470 chr3:125635718 C/A cg05084668 chr3:125655381 ALG1L -0.8 -11.75 -0.54 6.33e-27 Blood pressure (smoking interaction); LUSC cis rs9486719 1.000 rs12208011 chr6:96991105 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.74 -0.47 6.99e-20 Migraine;Coronary artery disease; LUSC trans rs72674100 1.000 rs72880559 chr4:97975513 A/G cg09670535 chr1:18959427 PAX7 -0.64 -6.61 -0.34 1.53e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg06718696 chr17:78121285 EIF4A3 0.45 6.42 0.33 4.72e-10 Yeast infection; LUSC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg22907277 chr7:1156413 C7orf50 0.72 10.41 0.5 3.54e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9653442 0.564 rs7590378 chr2:100789877 A/G cg07810366 chr2:100720526 AFF3 -0.43 -7.28 -0.37 2.43e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4595586 0.545 rs12827197 chr12:39404362 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.21 0.37 3.78e-12 Morning vs. evening chronotype; LUSC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg26566898 chr11:117069891 TAGLN -0.47 -8.28 -0.41 3.06e-15 Blood protein levels; LUSC cis rs7043114 0.525 rs10992374 chr9:95336327 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.44 -0.33 4.1e-10 Height; LUSC cis rs4595586 0.545 rs17546137 chr12:39401124 G/A cg13010199 chr12:38710504 ALG10B 0.44 6.23 0.32 1.4e-9 Morning vs. evening chronotype; LUSC cis rs7647973 0.560 rs77473999 chr3:49777660 T/C cg03060546 chr3:49711283 APEH -0.61 -7.08 -0.36 8.68e-12 Menarche (age at onset); LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg26314531 chr2:26401878 FAM59B 0.66 8.76 0.43 9.76e-17 Gut microbiome composition (summer); LUSC cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg16339924 chr4:17578868 LAP3 -0.58 -8.39 -0.42 1.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6752107 0.967 rs36001488 chr2:234185267 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.69 11.57 0.53 3e-26 Crohn's disease;Inflammatory bowel disease; LUSC trans rs2243480 1.000 rs68189316 chr7:65409169 C/G cg10756647 chr7:56101905 PSPH 0.86 8.4 0.42 1.27e-15 Diabetic kidney disease; LUSC cis rs12519773 0.526 rs4469186 chr5:92520266 T/C cg18783429 chr5:92414398 NA 0.34 7.16 0.36 5.13e-12 Migraine; LUSC cis rs4363385 0.647 rs1995308 chr1:153014082 A/T cg25856811 chr1:152973957 SPRR3 -0.4 -6.53 -0.34 2.42e-10 Inflammatory skin disease; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg00684032 chr4:1343700 KIAA1530 0.38 6.58 0.34 1.8e-10 Obesity-related traits; LUSC cis rs9646954 0.542 rs4149513 chr2:101022726 C/T cg12002119 chr2:101014098 CHST10 0.35 5.82 0.3 1.38e-8 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.863 rs3775849 chr4:120450908 G/C cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC trans rs12210905 1.000 rs12192446 chr6:26995638 C/A cg11837749 chr1:55047332 ACOT11 0.57 6.01 0.31 4.99e-9 Hip circumference adjusted for BMI; LUSC cis rs72781680 1.000 rs115861480 chr2:24129464 T/A cg08917208 chr2:24149416 ATAD2B 0.98 10.41 0.49 3.64e-22 Lymphocyte counts; LUSC trans rs11098499 0.739 rs4833612 chr4:120147596 A/C cg25214090 chr10:38739885 LOC399744 -0.41 -6.22 -0.32 1.52e-9 Corneal astigmatism; LUSC cis rs9815354 1.000 rs3934103 chr3:41977214 C/T cg03022575 chr3:42003672 ULK4 -0.59 -6.52 -0.34 2.53e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs7945705 0.875 rs10769955 chr11:8784647 G/C cg12365402 chr11:9010492 NRIP3 0.46 8.12 0.41 8.85e-15 Hemoglobin concentration; LUSC cis rs477692 1.000 rs548390 chr10:131417427 G/A cg26102564 chr10:131424627 MGMT 0.38 6.0 0.31 5.07e-9 Response to temozolomide; LUSC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg03388025 chr16:89894329 SPIRE2 0.32 6.56 0.34 2.01e-10 Vitiligo; LUSC cis rs4888262 0.526 rs4887777 chr16:74637821 A/G cg01733217 chr16:74700730 RFWD3 0.8 13.34 0.59 7.52e-33 Testicular germ cell tumor; LUSC cis rs6429082 0.818 rs453315 chr1:235680585 C/T cg26050004 chr1:235667680 B3GALNT2 0.63 8.4 0.42 1.34e-15 Adiposity; LUSC cis rs6690583 0.562 rs76839162 chr1:85530021 A/G cg22153463 chr1:85462885 MCOLN2 0.61 5.67 0.3 3.05e-8 Serum sulfate level; LUSC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.31 0.33 8.94e-10 Menopause (age at onset); LUSC trans rs7849782 0.967 rs1535632 chr9:104433973 A/T cg22914338 chr19:14376960 NA 0.25 6.14 0.32 2.35e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 9.57 0.46 2.54e-19 Mean platelet volume; LUSC cis rs8017423 0.935 rs3737035 chr14:90745422 T/C cg14092571 chr14:90743983 NA 0.35 5.71 0.3 2.5e-8 Mortality in heart failure; LUSC cis rs4900538 0.927 rs1190547 chr14:102905087 G/C cg18135206 chr14:102964638 TECPR2 -1.03 -21.67 -0.76 1.21e-65 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11677416 0.677 rs2856840 chr2:113538604 T/A cg27083787 chr2:113543245 IL1A 0.45 7.11 0.36 6.89e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs79349575 0.685 rs1124829 chr17:46967797 C/A cg22482690 chr17:47019901 SNF8 0.4 7.47 0.38 6.92e-13 Type 2 diabetes; LUSC cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs35306767 0.714 rs7075188 chr10:1088746 G/T cg26597838 chr10:835615 NA -0.53 -7.05 -0.36 1.03e-11 Eosinophil percentage of granulocytes; LUSC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg04733989 chr22:42467013 NAGA -0.42 -6.88 -0.35 2.94e-11 Cognitive function; LUSC cis rs308403 0.509 rs10016979 chr4:123673192 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.94 16.4 0.67 8.96e-45 Blood protein levels; LUSC cis rs9359856 0.564 rs72915944 chr6:90447226 C/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.55 -0.42 4.52e-16 Bipolar disorder; LUSC trans rs2235573 0.527 rs139862 chr22:38351986 T/C cg19894588 chr14:64061835 NA 0.54 7.7 0.39 1.56e-13 Glioblastoma;Glioma; LUSC cis rs9372253 0.564 rs2057151 chr6:110716608 G/C cg19196401 chr6:110721138 DDO -0.36 -5.75 -0.3 2.06e-8 Platelet distribution width; LUSC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs10089 0.953 rs4836359 chr5:127385518 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 12.09 0.55 3.72e-28 Ileal carcinoids; LUSC cis rs11758351 1.000 rs16891405 chr6:26204506 A/G cg23601095 chr6:26197514 HIST1H3D 0.73 7.79 0.39 8.56e-14 Gout;Renal underexcretion gout; LUSC cis rs9341808 0.527 rs2505946 chr6:80810683 A/G cg08355045 chr6:80787529 NA 0.63 11.89 0.55 1.93e-27 Sitting height ratio; LUSC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg20503657 chr10:835505 NA 0.99 13.72 0.6 2.8e-34 Eosinophil percentage of granulocytes; LUSC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg11645453 chr3:52864694 ITIH4 -0.42 -10.37 -0.49 5.15e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg03333052 chr10:5683763 ASB13 -0.38 -6.33 -0.33 7.84e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7267979 1.000 rs6037121 chr20:25428311 G/A cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -6.91 -0.35 2.4e-11 Psoriasis; LUSC cis rs7100689 0.646 rs10887808 chr10:82137367 G/A cg01528321 chr10:82214614 TSPAN14 0.87 13.18 0.58 3.14e-32 Post bronchodilator FEV1; LUSC cis rs4654899 0.865 rs72988025 chr1:21351441 A/G cg02927042 chr1:21476669 EIF4G3 -0.36 -5.65 -0.3 3.38e-8 Superior frontal gyrus grey matter volume; LUSC cis rs9612 0.718 rs346536 chr19:44251470 A/T cg08581076 chr19:44259116 C19orf61 0.49 6.29 0.33 9.86e-10 Exhaled nitric oxide output; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10814338 chr17:41132463 AARSD1;RUNDC1 -0.5 -6.57 -0.34 1.96e-10 Hepatitis; LUSC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg02269571 chr22:50332266 NA 0.59 8.74 0.43 1.17e-16 Schizophrenia; LUSC cis rs1451375 1.000 rs2329342 chr7:50624971 A/G cg18232548 chr7:50535776 DDC -0.52 -7.99 -0.4 2.23e-14 Malaria; LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.58 0.38 3.4e-13 Bipolar disorder; LUSC cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg05855489 chr10:104503620 C10orf26 0.53 7.78 0.39 9.07e-14 Arsenic metabolism; LUSC cis rs4243830 0.522 rs11122086 chr1:6601246 T/G cg05709478 chr1:6581295 PLEKHG5 -0.53 -6.38 -0.33 5.96e-10 Body mass index; LUSC cis rs12681287 0.640 rs7846090 chr8:87467724 A/T cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg08754478 chr10:133766260 PPP2R2D -0.6 -7.45 -0.38 7.81e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs1127311 1.000 rs1127313 chr1:154556425 A/G cg17218026 chr1:154582156 ADAR -0.56 -9.8 -0.47 4.35e-20 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22601191 chr20:60968625 CABLES2 -0.41 -6.62 -0.34 1.42e-10 Colorectal cancer; LUSC cis rs17685 0.753 rs8200 chr7:75696606 C/G cg16489192 chr7:75678113 MDH2;STYXL1 0.5 7.74 0.39 1.19e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4132509 0.947 rs320339 chr1:243870910 G/T cg21452805 chr1:244014465 NA 0.5 5.69 0.3 2.79e-8 RR interval (heart rate); LUSC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.29 0.33 1.02e-9 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20824237 chr3:99979579 TBC1D23 0.44 6.11 0.32 2.79e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs295140 0.546 rs842830 chr2:201131124 C/T cg23649088 chr2:200775458 C2orf69 -0.41 -6.2 -0.32 1.7e-9 QT interval; LUSC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg18758796 chr5:131593413 PDLIM4 -0.39 -6.18 -0.32 1.85e-9 Breast cancer; LUSC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg23711669 chr6:146136114 FBXO30 -0.93 -17.79 -0.7 2.95e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.909 rs6060679 chr20:30270772 C/G cg13852791 chr20:30311386 BCL2L1 -0.88 -11.85 -0.54 2.85e-27 Mean corpuscular hemoglobin; LUSC cis rs34891900 0.507 rs2535707 chr22:18181869 C/T cg19898043 chr22:18121309 BCL2L13 -0.39 -6.03 -0.31 4.41e-9 Sum neutrophil eosinophil counts; LUSC cis rs7712401 0.601 rs35858098 chr5:122334365 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.27 -0.45 2.29e-18 Mean platelet volume; LUSC cis rs9403521 0.898 rs3924969 chr6:143979399 C/G cg18240653 chr6:144019428 PHACTR2 -0.51 -6.13 -0.32 2.51e-9 Obesity-related traits; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg02050903 chr11:44117243 EXT2 0.35 6.07 0.32 3.4e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg08859206 chr1:53392774 SCP2 0.5 8.51 0.42 6.03e-16 Monocyte count; LUSC cis rs478304 0.934 rs610037 chr11:65546857 A/C cg27068330 chr11:65405492 SIPA1 0.64 9.76 0.47 5.64e-20 Acne (severe); LUSC cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg23796481 chr11:64053134 BAD;GPR137 0.51 7.98 0.4 2.37e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs865483 0.929 rs853225 chr17:35791505 A/C cg06716730 chr17:35851459 DUSP14 0.26 5.84 0.3 1.21e-8 Monocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10577284 chr10:81838377 LOC219347;C10orf57 -0.43 -6.53 -0.34 2.45e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7215564 0.908 rs35103651 chr17:78666732 T/C cg23238734 chr17:78661607 RPTOR 0.48 6.28 0.32 1.05e-9 Myopia (pathological); LUSC cis rs3859192 0.599 rs2227319 chr17:38170845 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.6 0.57 4.95e-30 White blood cell count; LUSC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg12292205 chr6:26970375 C6orf41 0.49 7.7 0.39 1.54e-13 Schizophrenia; LUSC cis rs8060686 0.516 rs2290699 chr16:68289059 C/T cg09835421 chr16:68378352 PRMT7 -0.52 -6.34 -0.33 7.38e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -6.94 -0.35 2.06e-11 Schizophrenia; LUSC cis rs6696846 0.715 rs12139373 chr1:205054879 A/C cg03948781 chr1:205179583 DSTYK 0.33 6.34 0.33 7.42e-10 Red blood cell count; LUSC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg21972741 chr5:435613 AHRR 0.33 5.87 0.31 1.02e-8 Cystic fibrosis severity; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.18 -0.32 1.91e-9 Platelet count; LUSC cis rs2224391 0.628 rs2753232 chr6:5250765 G/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.39 -0.33 5.72e-10 Height; LUSC cis rs7719624 0.756 rs13168506 chr5:135396452 A/G cg12897067 chr5:135418308 NA 0.4 5.82 0.3 1.36e-8 Response to cytidine analogues (gemcitabine); LUSC cis rs4595586 0.563 rs2388178 chr12:39364366 T/G cg13010199 chr12:38710504 ALG10B 0.42 6.12 0.32 2.66e-9 Morning vs. evening chronotype; LUSC cis rs12474201 0.928 rs34186074 chr2:46965010 T/C cg06386533 chr2:46925753 SOCS5 0.75 11.16 0.52 8.46e-25 Height; LUSC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg09517075 chr8:22133004 PIWIL2 0.41 8.07 0.4 1.28e-14 Hypertriglyceridemia; LUSC cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.32 0.53 2.37e-25 Colorectal cancer; LUSC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg06618935 chr21:46677482 NA -0.41 -8.29 -0.41 2.8e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg23172400 chr8:95962367 TP53INP1 -0.39 -8.19 -0.41 5.68e-15 Type 2 diabetes; LUSC cis rs7903847 0.642 rs1537645 chr10:99149914 T/C cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.26e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg18350739 chr11:68623251 NA -0.37 -6.71 -0.34 8.55e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg11764359 chr7:65958608 NA -0.54 -7.11 -0.36 7.23e-12 Aortic root size; LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg03354898 chr7:1950403 MAD1L1 -0.46 -9.57 -0.46 2.45e-19 Bipolar disorder and schizophrenia; LUSC cis rs4919694 0.572 rs12243903 chr10:104906992 T/C cg05855489 chr10:104503620 C10orf26 0.54 6.39 0.33 5.67e-10 Arsenic metabolism; LUSC cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg11247378 chr22:39784982 NA -0.66 -13.12 -0.58 5.14e-32 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.41 -7.8 -0.39 7.89e-14 Platelet count; LUSC cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 27.87 0.84 3.57e-89 Chronic sinus infection; LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg25767906 chr1:53392781 SCP2 0.49 8.87 0.44 4.4e-17 Monocyte count; LUSC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9527 0.662 rs4919686 chr10:104592249 A/C cg04362960 chr10:104952993 NT5C2 0.66 9.2 0.45 4.07e-18 Arsenic metabolism; LUSC cis rs7173743 0.935 rs11857877 chr15:79140838 G/C cg00540400 chr15:79124168 NA -0.34 -5.77 -0.3 1.84e-8 Coronary artery disease; LUSC cis rs1443512 0.755 rs1373160 chr12:54340383 A/G cg25024717 chr12:54324583 NA -0.4 -6.32 -0.33 8.56e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.58 -0.38 3.51e-13 Personality dimensions; LUSC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg01802117 chr1:53393560 SCP2 -0.37 -5.93 -0.31 7.62e-9 Monocyte count; LUSC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg18357526 chr6:26021779 HIST1H4A -0.41 -6.2 -0.32 1.63e-9 Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs2282971 chr7:91584356 A/G cg17063962 chr7:91808500 NA 0.55 8.76 0.43 1e-16 Breast cancer; LUSC trans rs72674100 0.737 rs72874649 chr4:97965312 T/C cg09670535 chr1:18959427 PAX7 -0.64 -6.61 -0.34 1.53e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg11764359 chr7:65958608 NA 0.69 10.56 0.5 1.14e-22 Aortic root size; LUSC cis rs17270561 0.723 rs12192635 chr6:25880907 A/T cg17691542 chr6:26056736 HIST1H1C 0.81 10.97 0.51 3.9e-24 Iron status biomarkers; LUSC cis rs7568458 0.783 rs2166529 chr2:85742175 A/C cg23752985 chr2:85803571 VAMP8 -0.3 -6.33 -0.33 7.83e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9311676 0.656 rs56097407 chr3:58378079 G/A cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 -0.48 -8.0 -0.4 2.09e-14 Vitiligo; LUSC trans rs35110281 0.591 rs162366 chr21:44935383 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.58 -10.23 -0.49 1.49e-21 Mean corpuscular volume; LUSC cis rs7191700 0.583 rs243314 chr16:11385104 G/C cg00044050 chr16:11439710 C16orf75 0.76 14.67 0.63 6.08e-38 Multiple sclerosis; LUSC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg23283495 chr1:209979779 IRF6 0.64 9.36 0.46 1.21e-18 Cleft lip with or without cleft palate; LUSC cis rs6545883 0.929 rs778155 chr2:61647901 A/G cg15711740 chr2:61764176 XPO1 0.45 6.74 0.35 6.91e-11 Tuberculosis; LUSC cis rs7666738 0.606 rs10006414 chr4:99101401 T/C cg05340658 chr4:99064831 C4orf37 0.59 9.59 0.46 2.05e-19 Colonoscopy-negative controls vs population controls; LUSC trans rs4942242 0.663 rs7332737 chr13:44215043 C/T cg19169023 chr15:41853346 TYRO3 -0.56 -8.45 -0.42 9.13e-16 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs75920871 0.528 rs11216240 chr11:116899248 A/T cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.42 -0.33 4.68e-10 Subjective well-being; LUSC cis rs4766646 0.542 rs4766489 chr12:110306345 G/A cg10794374 chr12:110278745 NA -0.28 -5.81 -0.3 1.44e-8 Metabolite levels (MHPG); LUSC cis rs8092503 1.000 rs12959833 chr18:52492579 A/G cg12377874 chr18:52495404 RAB27B -0.34 -6.18 -0.32 1.91e-9 Childhood body mass index; LUSC cis rs2425143 1.000 rs8124505 chr20:34307247 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.05 -0.31 3.95e-9 Blood protein levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg22225258 chr1:1447235 ATAD3A 0.37 5.98 0.31 5.76e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4764124 0.646 rs11610238 chr12:14975721 C/T cg19759883 chr12:14956454 WBP11;C12orf60 0.38 5.87 0.31 1.06e-8 Pubertal anthropometrics; LUSC cis rs10191773 0.589 rs6761440 chr2:112959193 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.6 -6.83 -0.35 3.93e-11 Yeast infection; LUSC cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg22709100 chr7:91322751 NA 0.39 5.71 0.3 2.49e-8 Breast cancer; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg19346786 chr7:2764209 NA -0.49 -8.16 -0.41 7.09e-15 Height; LUSC cis rs3820928 0.874 rs1917125 chr2:227798981 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.38e-13 Pulmonary function; LUSC cis rs6076065 0.755 rs6076071 chr20:23406380 A/C cg11657817 chr20:23433608 CST11 0.4 7.13 0.36 6.42e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs4954585 0.593 rs12691881 chr2:137029668 A/G cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.68e-13 Colorectal cancer; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 8.03e-17 Prudent dietary pattern; LUSC cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg06552810 chr11:31128660 NA 0.42 7.24 0.37 3.07e-12 Red blood cell count; LUSC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg06634786 chr22:41940651 POLR3H -0.55 -6.46 -0.33 3.75e-10 Vitiligo; LUSC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg13798780 chr7:105162888 PUS7 0.56 6.04 0.31 4.04e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9467773 1.000 rs6940053 chr6:26562122 C/T cg11502198 chr6:26597334 ABT1 0.63 9.95 0.48 1.31e-20 Intelligence (multi-trait analysis); LUSC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg24250549 chr1:154909240 PMVK 0.57 9.16 0.45 5.55e-18 Prostate cancer; LUSC cis rs73206853 0.563 rs1107652 chr12:111176213 A/G cg12870014 chr12:110450643 ANKRD13A 0.65 7.4 0.38 1.08e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.68 -0.43 1.83e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7786877 0.582 rs2075674 chr7:100225031 G/A cg20848291 chr7:100343083 ZAN -0.6 -7.22 -0.37 3.47e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg22166914 chr1:53195759 ZYG11B 0.69 12.45 0.56 1.67e-29 Monocyte count; LUSC cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg26384229 chr12:38710491 ALG10B -0.88 -15.11 -0.64 1.1e-39 Bladder cancer; LUSC trans rs10802346 0.545 rs4478780 chr1:246372241 T/C cg13514129 chr1:39547527 MACF1 0.71 11.79 0.54 4.48e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg11335335 chr11:637885 DRD4 -0.31 -5.95 -0.31 6.74e-9 Systemic lupus erythematosus; LUSC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg08677398 chr8:58056175 NA 0.41 5.71 0.3 2.51e-8 Developmental language disorder (linguistic errors); LUSC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg10792982 chr14:105748885 BRF1 0.48 8.66 0.43 2.11e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs4363385 0.818 rs558363 chr1:153010431 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC trans rs7618501 0.633 rs11925192 chr3:50038664 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.55 8.87 0.44 4.4e-17 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg02782426 chr3:40428986 ENTPD3 -0.37 -7.15 -0.36 5.66e-12 Renal cell carcinoma; LUSC cis rs56307353 0.753 rs34318825 chr19:1961342 T/C cg11709110 chr19:1989583 BTBD2 -0.33 -5.66 -0.3 3.24e-8 Coronary artery disease; LUSC cis rs6964587 0.692 rs4729025 chr7:91847504 C/T cg17063962 chr7:91808500 NA 0.61 10.19 0.49 2e-21 Breast cancer; LUSC cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg11266682 chr4:10021025 SLC2A9 0.47 8.46 0.42 8.29e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs34293785 1.000 rs34293785 chr1:66137192 T/C cg04111102 chr1:66153794 NA 0.34 7.38 0.37 1.29e-12 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Sum basophil neutrophil counts;Neutrophil count;White blood cell count; LUSC cis rs7833790 0.777 rs10958042 chr8:82678393 G/T cg02079420 chr8:82753780 SNX16 0.39 5.92 0.31 8.18e-9 Diastolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06349981 chr2:10443745 HPCAL1 -0.47 -6.21 -0.32 1.62e-9 Bipolar disorder and schizophrenia; LUSC cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg09467607 chr2:36825704 FEZ2 0.54 11.56 0.53 3.14e-26 Height; LUSC cis rs55665837 0.539 rs12794714 chr11:14913575 G/A cg19336497 chr11:14380999 RRAS2 -0.33 -5.96 -0.31 6.43e-9 Vitamin D levels; LUSC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg23711669 chr6:146136114 FBXO30 0.92 17.48 0.69 4.97e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs2406342 0.511 rs10469087 chr18:74575538 A/C cg16472389 chr18:74514291 NA 0.43 6.59 0.34 1.75e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); LUSC cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg16850897 chr7:100343110 ZAN 0.36 5.75 0.3 1.99e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs9653442 0.527 rs2118280 chr2:100746395 G/A cg07810366 chr2:100720526 AFF3 -0.42 -7.12 -0.36 6.61e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg11102782 chr19:18549136 ISYNA1 -0.35 -6.54 -0.34 2.34e-10 Breast cancer; LUSC cis rs2455601 0.882 rs11042106 chr11:8896083 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.5 7.37 0.37 1.39e-12 Schizophrenia; LUSC trans rs3960554 0.808 rs111764601 chr7:75706141 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 9.54 0.46 3.1400000000000002e-19 Eotaxin levels; LUSC cis rs10761482 0.500 rs10740030 chr10:62291812 C/G cg18175470 chr10:62150864 ANK3 -0.51 -7.7 -0.39 1.58e-13 Schizophrenia; LUSC cis rs977987 0.806 rs11862095 chr16:75385418 T/A cg03315344 chr16:75512273 CHST6 0.54 10.31 0.49 8.01e-22 Dupuytren's disease; LUSC cis rs1322512 0.917 rs2623941 chr6:152950973 A/C cg27316956 chr6:152958899 SYNE1 -0.35 -5.88 -0.31 1e-8 Tonometry; LUSC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg15445000 chr17:37608096 MED1 -0.39 -6.72 -0.35 7.97e-11 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.94 0.4 3.06e-14 Bipolar disorder; LUSC cis rs72781680 0.898 rs2879640 chr2:24043573 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg08847533 chr14:75593920 NEK9 -0.8 -13.68 -0.6 3.91e-34 Height; LUSC cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg12011299 chr4:100065546 ADH4 0.71 10.85 0.51 1.08e-23 Smoking initiation; LUSC cis rs9300255 0.596 rs4460848 chr12:123677810 A/G cg05973401 chr12:123451056 ABCB9 0.52 7.0 0.36 1.44e-11 Neutrophil percentage of white cells; LUSC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg23649088 chr2:200775458 C2orf69 0.54 7.34 0.37 1.61e-12 Schizophrenia; LUSC cis rs950776 0.714 rs472054 chr15:78887994 A/G cg06917634 chr15:78832804 PSMA4 -0.69 -11.2 -0.52 6.3e-25 Sudden cardiac arrest; LUSC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg15448220 chr1:150897856 SETDB1 0.39 5.87 0.31 1.04e-8 Tonsillectomy; LUSC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg20790798 chr5:1857306 NA -0.49 -8.54 -0.42 4.92e-16 Cardiovascular disease risk factors; LUSC cis rs9807989 0.507 rs2058659 chr2:103054556 A/G cg03938978 chr2:103052716 IL18RAP -0.37 -7.12 -0.36 6.52e-12 Asthma; LUSC cis rs9549260 0.755 rs7324319 chr13:41233505 G/C cg21288729 chr13:41239152 FOXO1 0.65 9.98 0.48 1.06e-20 Red blood cell count; LUSC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg11764359 chr7:65958608 NA -0.71 -11.04 -0.52 2.31e-24 Aortic root size; LUSC cis rs7927592 0.546 rs554734 chr11:68192518 T/G cg01657329 chr11:68192670 LRP5 -0.48 -7.2 -0.37 4.07e-12 Total body bone mineral density; LUSC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg20503657 chr10:835505 NA 1.0 14.14 0.61 6.49e-36 Eosinophil percentage of granulocytes; LUSC cis rs193541 0.530 rs2125857 chr5:122083156 G/A cg19077854 chr5:122220652 SNX24 0.36 7.15 0.36 5.53e-12 Glucose homeostasis traits; LUSC cis rs523522 0.962 rs670568 chr12:121021206 C/T cg12219531 chr12:120966889 COQ5 0.66 9.11 0.45 7.8e-18 High light scatter reticulocyte count; LUSC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.38 7.15 0.36 5.66e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg12463550 chr7:65579703 CRCP 0.64 5.83 0.3 1.3e-8 Diabetic kidney disease; LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg05896524 chr21:47604654 C21orf56 -0.48 -7.53 -0.38 4.88e-13 Testicular germ cell tumor; LUSC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg00129232 chr17:37814104 STARD3 -0.4 -5.72 -0.3 2.33e-8 Asthma; LUSC cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs2857891 0.817 rs2857899 chr11:6981668 A/C cg14883916 chr11:6947541 ZNF215 0.45 5.83 0.3 1.29e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg12516959 chr21:47718080 NA -0.47 -7.48 -0.38 6.84e-13 Testicular germ cell tumor; LUSC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg06637938 chr14:75390232 RPS6KL1 0.44 6.55 0.34 2.23e-10 Height; LUSC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg13390004 chr1:15929781 NA 0.42 7.04 0.36 1.07e-11 Systolic blood pressure; LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg04944784 chr2:26401820 FAM59B -0.74 -11.06 -0.52 1.87e-24 Gut microbiome composition (summer); LUSC cis rs9534288 0.740 rs7989892 chr13:46630641 C/T cg15192986 chr13:46630673 CPB2 -0.8 -12.6 -0.57 4.66e-30 Blood protein levels; LUSC cis rs17253792 0.822 rs28754619 chr14:56088394 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs829883 0.664 rs249833 chr12:98832189 T/C cg25150519 chr12:98850993 NA 0.8 13.45 0.59 3.01e-33 Colorectal adenoma (advanced); LUSC cis rs2439831 0.681 rs825739 chr15:43592428 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.37 0.53 1.5e-25 Lung cancer in ever smokers; LUSC cis rs68170813 0.559 rs78267892 chr7:106823734 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.8 -0.47 4.39e-20 Coronary artery disease; LUSC cis rs17621444 0.522 rs4237515 chr10:121811588 T/A cg02041677 chr10:121771263 NA -0.33 -6.31 -0.33 9.11e-10 IgG glycosylation; LUSC cis rs11098499 0.954 rs7436506 chr4:120393769 T/C cg09307838 chr4:120376055 NA 0.79 11.5 0.53 5.34e-26 Corneal astigmatism; LUSC cis rs2637266 0.967 rs12246605 chr10:78352994 G/A cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs3960554 0.599 rs56090527 chr7:75762125 A/C cg17325771 chr7:75508891 RHBDD2 -0.41 -5.8 -0.3 1.57e-8 Eotaxin levels; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg05552183 chr6:42928497 GNMT 0.46 7.5 0.38 5.63e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12908161 1.000 rs11638290 chr15:85227636 C/T cg12863693 chr15:85201151 NMB 0.42 8.65 0.43 2.14e-16 Schizophrenia; LUSC cis rs34779708 0.931 rs1926554 chr10:35344969 C/T cg04310649 chr10:35416472 CREM -0.4 -6.13 -0.32 2.5e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9379945 1 rs9379945 chr6:26907831 T/C cg09904177 chr6:26538194 HMGN4 -0.64 -6.41 -0.33 4.96e-10 Intelligence (multi-trait analysis); LUSC cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.84 12.69 0.57 2.13e-30 Cognitive ability; LUSC cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25765569 chr12:117175636 C12orf49;RNFT2 -0.5 -6.46 -0.33 3.69e-10 Bipolar disorder and schizophrenia; LUSC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg01448562 chr3:133502909 NA -0.51 -7.61 -0.38 2.88e-13 Iron status biomarkers; LUSC cis rs2463822 0.858 rs2463836 chr11:62126494 A/G cg06239285 chr11:62104954 ASRGL1 0.98 10.97 0.51 4.05e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4481887 0.617 rs7511986 chr1:248527810 G/A cg26353448 chr1:248524236 OR2T4 -0.31 -6.06 -0.31 3.63e-9 Common traits (Other); LUSC cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg15103426 chr22:29168792 CCDC117 0.46 5.91 0.31 8.34e-9 Lymphocyte counts; LUSC cis rs3744061 0.557 rs2098092 chr17:74646757 T/C cg27546012 chr17:74684504 MXRA7 -0.37 -6.37 -0.33 6.19e-10 Retinal arteriolar caliber; LUSC cis rs16867321 0.588 rs2368175 chr2:181493763 G/C cg23363182 chr2:181467187 NA -0.58 -9.13 -0.45 6.87e-18 Obesity; LUSC cis rs73206853 0.841 rs55951950 chr12:110800254 A/T cg12870014 chr12:110450643 ANKRD13A 0.68 6.43 0.33 4.37e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7582180 0.652 rs11675901 chr2:100951189 G/A cg08017756 chr2:100939284 LONRF2 -0.47 -8.8 -0.43 7.7e-17 Intelligence (multi-trait analysis); LUSC trans rs10256972 0.539 rs2949174 chr7:1213923 T/C cg22582392 chr4:160024851 NA -0.45 -5.97 -0.31 6.14e-9 Longevity;Endometriosis; LUSC cis rs2637266 0.967 rs10400134 chr10:78365158 G/C cg18941641 chr10:78392320 NA 0.41 7.59 0.38 3.18e-13 Pulmonary function; LUSC cis rs11098499 0.629 rs28369518 chr4:120271630 T/C cg09307838 chr4:120376055 NA 0.63 9.59 0.46 2.07e-19 Corneal astigmatism; LUSC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.21 0.41 4.9e-15 Prudent dietary pattern; LUSC cis rs2204008 0.537 rs28680519 chr12:38502946 C/T cg26384229 chr12:38710491 ALG10B 0.88 14.59 0.62 1.18e-37 Bladder cancer; LUSC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs66887589 0.592 rs11731571 chr4:120221185 G/A cg13609457 chr4:120235615 NA 0.39 5.98 0.31 5.71e-9 Diastolic blood pressure; LUSC cis rs4891159 0.570 rs690132 chr18:74117261 T/C cg24786174 chr18:74118243 ZNF516 0.97 21.55 0.76 3.54e-65 Longevity; LUSC cis rs1358748 0.522 rs1321155 chr1:67589479 G/C cg02640540 chr1:67518911 SLC35D1 0.67 6.55 0.34 2.15e-10 Tuberculosis; LUSC cis rs9309473 1.000 rs10207220 chr2:73785046 G/C cg20560298 chr2:73613845 ALMS1 -0.45 -6.5 -0.33 2.97e-10 Metabolite levels; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg18538332 chr22:24372958 LOC391322 -0.42 -7.67 -0.39 1.89e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg14829155 chr15:31115871 NA 0.7 10.47 0.5 2.21e-22 Huntington's disease progression; LUSC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg03538708 chr1:25844672 NA -0.39 -6.48 -0.33 3.22e-10 Plateletcrit;Mean corpuscular volume; LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg20821713 chr7:1055600 C7orf50 0.47 7.66 0.39 2.01e-13 Longevity;Endometriosis; LUSC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11644478 chr21:40555479 PSMG1 0.89 16.17 0.66 7.73e-44 Cognitive function; LUSC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs2742234 1.000 rs2742234 chr10:43612609 A/G cg15436174 chr10:43711423 RASGEF1A 0.33 6.05 0.31 3.78e-9 Hirschsprung disease; LUSC cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg04450456 chr4:17643702 FAM184B -0.38 -6.28 -0.33 1.04e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06634786 chr22:41940651 POLR3H 0.49 6.04 0.31 4.01e-9 Vitiligo; LUSC cis rs13092825 1.000 rs7613948 chr3:113279698 T/G cg18753928 chr3:113234510 CCDC52 -0.38 -5.65 -0.3 3.5e-8 Dental caries; LUSC cis rs10979 1.000 rs1416208 chr6:143889241 T/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg11262906 chr1:85462892 MCOLN2 -0.68 -9.06 -0.44 1.09e-17 Serum sulfate level; LUSC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg03060546 chr3:49711283 APEH 0.47 6.29 0.33 1.02e-9 Menarche (age at onset); LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.88 0.63 8.88e-39 Platelet count; LUSC cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg13531842 chr10:38383804 ZNF37A -0.44 -6.77 -0.35 5.91e-11 Extrinsic epigenetic age acceleration; LUSC cis rs2286503 0.839 rs2270103 chr7:22862722 C/T cg11367502 chr7:22862612 TOMM7 0.46 6.22 0.32 1.51e-9 Fibrinogen; LUSC trans rs61931739 0.517 rs7958755 chr12:34294699 T/C cg13010199 chr12:38710504 ALG10B 0.53 8.24 0.41 4.01e-15 Morning vs. evening chronotype; LUSC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg17724175 chr1:150552817 MCL1 0.32 5.74 0.3 2.08e-8 Tonsillectomy; LUSC cis rs2274273 0.624 rs11848456 chr14:55755392 A/G cg04306507 chr14:55594613 LGALS3 0.48 9.85 0.47 2.9e-20 Protein biomarker; LUSC cis rs981844 0.816 rs62325151 chr4:154730595 A/G cg14289246 chr4:154710475 SFRP2 0.48 6.35 0.33 7.08e-10 Response to statins (LDL cholesterol change); LUSC cis rs11997175 0.550 rs10105616 chr8:33786830 G/A ch.8.33884649F chr8:33765107 NA 0.45 7.05 0.36 1.03e-11 Body mass index; LUSC cis rs9650315 0.852 rs7833122 chr8:57178720 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC cis rs1005277 0.691 rs2474558 chr10:38486141 A/C cg25427524 chr10:38739819 LOC399744 0.66 10.76 0.51 2.23e-23 Extrinsic epigenetic age acceleration; LUSC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg18350739 chr11:68623251 NA -0.37 -6.48 -0.33 3.28e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9790314 1.000 rs9872514 chr3:161042833 T/C cg03342759 chr3:160939853 NMD3 -0.5 -8.51 -0.42 5.77e-16 Morning vs. evening chronotype; LUSC trans rs7937682 0.924 rs10891284 chr11:111527737 T/C cg18187862 chr3:45730750 SACM1L 0.55 7.09 0.36 8.01e-12 Primary sclerosing cholangitis; LUSC cis rs208520 0.690 rs1885100 chr6:66871047 C/G cg07460842 chr6:66804631 NA -1.13 -17.85 -0.7 1.6e-50 Exhaled nitric oxide output; LUSC cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg00677455 chr12:58241039 CTDSP2 0.54 7.86 0.4 5.27e-14 Intelligence (multi-trait analysis); LUSC cis rs11264799 0.581 rs849815 chr1:157542162 A/G cg18268488 chr1:157545234 FCRL4 0.37 6.91 0.35 2.46e-11 IgA nephropathy; LUSC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg12463550 chr7:65579703 CRCP -0.55 -8.03 -0.4 1.68e-14 Aortic root size; LUSC cis rs56283067 0.847 rs62435999 chr6:44695273 T/G cg18551225 chr6:44695536 NA -0.48 -8.11 -0.41 9.47e-15 Total body bone mineral density; LUSC cis rs941408 1.000 rs1736179 chr19:2795516 T/A cg06609049 chr19:2785107 THOP1 0.72 11.74 0.54 6.87e-27 Total cholesterol levels; LUSC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg23982607 chr1:1823379 GNB1 -0.73 -15.07 -0.64 1.66e-39 Body mass index; LUSC trans rs3960554 0.808 rs4728587 chr7:75803132 C/T cg19862616 chr7:65841803 NCRNA00174 0.9 10.09 0.48 4.56e-21 Eotaxin levels; LUSC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg18357526 chr6:26021779 HIST1H4A 0.41 6.38 0.33 5.91e-10 Intelligence (multi-trait analysis); LUSC cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs6500395 0.775 rs1968902 chr16:48663974 A/G cg04672837 chr16:48644449 N4BP1 0.47 7.03 0.36 1.18e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg24562669 chr7:97807699 LMTK2 0.37 6.42 0.33 4.68e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1670533 1.000 rs633556 chr4:1092405 A/G cg27284194 chr4:1044797 NA 0.58 8.54 0.42 4.73e-16 Recombination rate (females); LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg05165339 chr4:1420672 NA 0.28 6.19 0.32 1.72e-9 Obesity-related traits; LUSC cis rs61931739 0.500 rs10844789 chr12:34202279 C/G cg06521331 chr12:34319734 NA -0.46 -7.55 -0.38 4.16e-13 Morning vs. evening chronotype; LUSC cis rs2932538 0.885 rs6693880 chr1:113110261 A/G cg22162597 chr1:113214053 CAPZA1 0.7 10.0 0.48 9.16e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs62400317 0.762 rs10484626 chr6:44882271 A/G cg18551225 chr6:44695536 NA -0.47 -7.71 -0.39 1.46e-13 Total body bone mineral density; LUSC cis rs7503807 0.837 rs9915667 chr17:78754340 A/G cg09596252 chr17:78655493 RPTOR -0.43 -7.41 -0.38 1.07e-12 Obesity; LUSC cis rs2933343 0.649 rs1683786 chr3:128626952 T/C cg11901034 chr3:128598214 ACAD9 -0.42 -6.61 -0.34 1.5e-10 IgG glycosylation; LUSC cis rs34779708 0.931 rs11010067 chr10:35295431 C/G cg03585969 chr10:35415529 CREM -0.6 -8.82 -0.43 6.44e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.6 0.34 1.66e-10 Lung cancer; LUSC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg24879335 chr3:133465180 TF 0.44 7.51 0.38 5.5e-13 Iron status biomarkers (transferrin levels); LUSC cis rs5753037 0.809 rs713657 chr22:30211876 A/G cg11564601 chr22:30592435 NA 0.32 5.72 0.3 2.39e-8 Type 1 diabetes; LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg08859206 chr1:53392774 SCP2 0.77 14.99 0.63 3.42e-39 Monocyte count; LUSC cis rs9951602 0.703 rs2959407 chr18:76682915 A/G cg00806245 chr18:76673096 NA -0.42 -6.09 -0.32 3.15e-9 Obesity-related traits; LUSC cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg22782873 chr19:19639568 YJEFN3 0.5 6.03 0.31 4.38e-9 Bipolar disorder; LUSC cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -8.17 -0.41 6.4e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3760982 0.585 rs1386502 chr19:44293356 T/C cg11993925 chr19:44307056 LYPD5 0.35 7.61 0.38 2.79e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs7659604 0.521 rs13130789 chr4:122690166 G/A cg19748678 chr4:122722346 EXOSC9 -0.48 -6.92 -0.35 2.35e-11 Type 2 diabetes; LUSC trans rs7726839 0.540 rs12520279 chr5:657291 T/C cg11887960 chr12:57824829 NA 0.52 6.49 0.33 3.12e-10 Obesity-related traits; LUSC cis rs2456568 0.570 rs1827932 chr11:93663319 A/T cg26875233 chr11:93583750 C11orf90 -0.31 -6.04 -0.31 4.07e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07274998 chr10:126107781 OAT -0.4 -6.1 -0.32 2.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs12200782 0.932 rs72844476 chr6:26574150 C/T cg11502198 chr6:26597334 ABT1 -0.74 -5.69 -0.3 2.8e-8 Small cell lung carcinoma; LUSC cis rs2980439 0.607 rs2980419 chr8:8114141 A/T cg15556689 chr8:8085844 FLJ10661 0.81 13.28 0.59 1.29e-32 Neuroticism; LUSC trans rs9329221 0.537 rs2062331 chr8:9979992 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.53 -0.34 2.44e-10 Neuroticism; LUSC cis rs9393777 0.623 rs7773938 chr6:26474044 C/T cg12826209 chr6:26865740 GUSBL1 0.67 7.65 0.39 2.16e-13 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.590 rs11123828 chr2:100960918 T/G cg12002119 chr2:101014098 CHST10 0.34 5.68 0.3 2.92e-8 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg05347473 chr6:146136440 FBXO30 0.45 7.69 0.39 1.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1372520 0.684 rs2583979 chr4:90750588 A/T cg01966878 chr4:90757139 SNCA -0.42 -5.96 -0.31 6.24e-9 Neuroticism; LUSC cis rs3820928 0.874 rs7421491 chr2:227839278 C/A cg11843606 chr2:227700838 RHBDD1 -0.55 -7.91 -0.4 3.86e-14 Pulmonary function; LUSC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg00484396 chr16:3507460 NAT15 0.88 11.7 0.54 9.96e-27 Tuberculosis; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg25703541 chr22:24373054 LOC391322 -1.0 -18.24 -0.71 4.62e-52 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs61990749 0.544 rs2544567 chr14:78181739 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.59 6.45 0.33 3.85e-10 Fibroblast growth factor basic levels; LUSC trans rs710987 0.740 rs698144 chr5:3528233 A/G cg27629735 chr1:3556483 WDR8 -0.36 -6.07 -0.32 3.45e-9 Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis; LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg01879757 chr17:41196368 BRCA1 -0.39 -5.9 -0.31 8.83e-9 Menopause (age at onset); LUSC cis rs11190604 1.000 rs10883507 chr10:102291275 C/T cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.26e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4363385 0.818 rs679378 chr1:153011716 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.25 -0.37 2.85e-12 Inflammatory skin disease; LUSC cis rs1256061 0.603 rs1256044 chr14:64734027 G/A cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.18e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs7944735 0.517 rs74763661 chr11:48233772 T/C cg03929089 chr4:120376271 NA 0.65 6.08 0.32 3.36e-9 Intraocular pressure; LUSC cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.46 0.69 5.95e-49 Chronic sinus infection; LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg26314531 chr2:26401878 FAM59B 0.73 10.01 0.48 8.34e-21 Gut microbiome composition (summer); LUSC cis rs701145 0.556 rs355764 chr3:154013480 A/T cg10247383 chr3:153839028 SGEF -0.47 -5.82 -0.3 1.38e-8 Coronary artery disease; LUSC cis rs12208915 0.731 rs9361473 chr6:79657042 C/T cg05283184 chr6:79620031 NA 0.48 7.25 0.37 2.86e-12 Left atrial antero-posterior diameter; LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg00634984 chr7:65235879 NA 0.43 6.16 0.32 2.11e-9 Calcium levels; LUSC cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg01028140 chr2:1542097 TPO -0.6 -8.02 -0.4 1.86e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.22 0.32 1.45e-9 Schizophrenia; LUSC cis rs1595825 0.891 rs2164070 chr2:198881730 G/C cg10547527 chr2:198650123 BOLL -0.53 -6.36 -0.33 6.65e-10 Ulcerative colitis; LUSC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.8 -0.35 4.8e-11 Alzheimer's disease (late onset); LUSC cis rs977987 0.800 rs11645329 chr16:75336679 C/G cg04384234 chr16:75411784 CFDP1 -0.36 -5.68 -0.3 2.97e-8 Dupuytren's disease; LUSC trans rs853679 0.546 rs36116761 chr6:27818482 C/G cg06606381 chr12:133084897 FBRSL1 -1.02 -9.08 -0.44 9.93e-18 Depression; LUSC trans rs6951245 0.832 rs10266519 chr7:1142977 C/T cg13565492 chr6:43139072 SRF -0.61 -6.83 -0.35 3.92e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg26874164 chr19:58962979 ZNF324B 0.7 10.93 0.51 5.71e-24 Mean platelet volume; LUSC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs4566357 0.615 rs10184991 chr2:227916533 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -8.13 -0.41 8.2e-15 Coronary artery disease; LUSC cis rs10203711 1.000 rs907111 chr2:239566426 T/C cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg02428538 chr16:24856791 SLC5A11 -0.52 -6.09 -0.32 3.18e-9 Intelligence (multi-trait analysis); LUSC cis rs244731 0.959 rs918459 chr5:176669030 C/T cg17509989 chr5:176798049 RGS14 -0.66 -9.51 -0.46 3.85e-19 Urate levels in lean individuals; LUSC cis rs10911251 0.528 rs2093982 chr1:183094191 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Colorectal cancer; LUSC cis rs1775715 0.678 rs7096139 chr10:32217404 A/C cg26784012 chr10:32216390 ARHGAP12 0.41 6.88 0.35 2.99e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1355223 0.545 rs7111695 chr11:34874906 T/G cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.69 -0.34 9.51e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg11812906 chr14:75593930 NEK9 -0.67 -11.56 -0.53 3.21e-26 Height; LUSC cis rs4919087 1.000 rs4919091 chr10:99088682 A/T cg25902810 chr10:99078978 FRAT1 -0.46 -6.72 -0.35 7.88e-11 Monocyte count; LUSC cis rs921968 0.613 rs2303565 chr2:219545309 T/C cg02176678 chr2:219576539 TTLL4 -0.59 -10.42 -0.5 3.24e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs7127129 0.503 rs1131715 chr11:70053487 C/T cg06159181 chr11:70072977 NA -0.27 -6.74 -0.35 7.13e-11 Aortic root size; LUSC cis rs6772849 0.896 rs61112519 chr3:128338176 T/A cg16766828 chr3:128327626 NA -0.31 -5.68 -0.3 2.9e-8 Monocyte percentage of white cells;Monocyte count; LUSC cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg23625390 chr15:77176239 SCAPER 0.54 8.36 0.42 1.77e-15 Blood metabolite levels; LUSC cis rs1691799 0.899 rs1168295 chr12:66734151 G/C cg16791601 chr12:66731901 HELB -0.71 -12.65 -0.57 3.03e-30 White blood cell count (basophil); LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.03 -0.31 4.23e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.18 0.32 1.91e-9 Bipolar disorder; LUSC cis rs62400317 0.859 rs72858517 chr6:45223467 A/C cg20913747 chr6:44695427 NA -0.47 -7.72 -0.39 1.41e-13 Total body bone mineral density; LUSC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg20243544 chr17:37824526 PNMT 0.49 7.01 0.36 1.36e-11 Asthma; LUSC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg03676636 chr4:99064102 C4orf37 0.37 8.14 0.41 7.81e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs11785400 0.731 rs4736363 chr8:143742112 C/A cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg09074113 chr2:20870087 GDF7 -0.37 -7.58 -0.38 3.38e-13 Abdominal aortic aneurysm; LUSC trans rs61931739 0.517 rs9668303 chr12:34366701 C/T cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.94e-21 Morning vs. evening chronotype; LUSC cis rs7568458 0.905 rs17026396 chr2:85759127 C/T cg23752985 chr2:85803571 VAMP8 -0.33 -7.11 -0.36 6.93e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg24675658 chr1:53192096 ZYG11B -0.64 -10.06 -0.48 5.86e-21 Monocyte count; LUSC cis rs9457247 0.544 rs6920858 chr6:167464630 G/A cg07741184 chr6:167504864 NA 0.49 8.62 0.43 2.75e-16 Crohn's disease; LUSC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg12560992 chr17:57184187 TRIM37 0.8 14.01 0.61 2.12e-35 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Parkinson's disease; LUSC cis rs7903847 0.667 rs7096801 chr10:99140969 T/C cg08345082 chr10:99160200 RRP12 -0.36 -7.28 -0.37 2.45e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg04865166 chr7:105162814 PUS7 0.51 5.71 0.3 2.49e-8 Bipolar disorder (body mass index interaction); LUSC cis rs3862030 0.839 rs7078679 chr10:104284017 C/G cg05855489 chr10:104503620 C10orf26 0.5 7.5 0.38 5.98e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2289328 0.823 rs71472433 chr15:40649609 A/C cg13931752 chr15:40660718 DISP2 0.48 6.49 0.33 3.04e-10 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs11608355 0.846 rs4766598 chr12:109853306 A/G cg19025524 chr12:109796872 NA -0.4 -5.89 -0.31 9.48e-9 Neuroticism; LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg05368731 chr17:41323189 NBR1 0.94 16.43 0.67 6.94e-45 Menopause (age at onset); LUSC trans rs853679 0.546 rs200995 chr6:27813694 C/T cg06606381 chr12:133084897 FBRSL1 0.8 7.91 0.4 3.74e-14 Depression; LUSC trans rs9380880 0.826 rs9380882 chr6:39547428 A/T cg09045552 chr2:169506620 LASS6 0.73 6.56 0.34 2.11e-10 Immune response to smallpox vaccine (IL-6); LUSC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg03929089 chr4:120376271 NA -1.03 -20.12 -0.74 1.48e-59 Height; LUSC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg26979012 chr14:53174064 PSMC6 0.36 6.15 0.32 2.21e-9 Tuberculosis; LUSC cis rs997295 0.675 rs12902804 chr15:67988658 G/A cg08079166 chr15:68083412 MAP2K5 -0.33 -6.49 -0.33 3.14e-10 Motion sickness; LUSC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg06022373 chr22:39101656 GTPBP1 0.89 14.68 0.63 5.52e-38 Menopause (age at onset); LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg16393715 chr7:1948819 MAD1L1 0.39 6.72 0.34 8.09e-11 Bipolar disorder and schizophrenia; LUSC cis rs12908161 1.000 rs12905057 chr15:85210765 A/G cg12863693 chr15:85201151 NMB 0.4 8.22 0.41 4.47e-15 Schizophrenia; LUSC cis rs4631830 0.720 rs11004422 chr10:51498336 A/G cg10326726 chr10:51549505 MSMB 0.34 5.88 0.31 9.99e-9 Prostate-specific antigen levels; LUSC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg14552801 chr7:65878734 NA -0.43 -6.14 -0.32 2.38e-9 Aortic root size; LUSC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs9948 0.655 rs62156221 chr2:97410850 A/G cg01990225 chr2:97406019 LMAN2L -1.04 -7.26 -0.37 2.8e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs12579753 1.000 rs7963577 chr12:82174115 T/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.97 -0.31 6.07e-9 Resting heart rate; LUSC cis rs7647973 0.626 rs11130217 chr3:49737323 A/G cg03060546 chr3:49711283 APEH 0.63 7.35 0.37 1.52e-12 Menarche (age at onset); LUSC trans rs2243480 1.000 rs316330 chr7:65605372 C/A cg10756647 chr7:56101905 PSPH 0.9 9.03 0.44 1.4e-17 Diabetic kidney disease; LUSC cis rs8081692 1 rs8081692 chr17:38154595 A/G cg17467752 chr17:38218738 THRA 0.78 12.54 0.57 7.66e-30 Neutrophil count; LUSC cis rs13401104 0.796 rs1466204 chr2:237121154 C/A cg19324714 chr2:237145437 ASB18 0.44 5.66 0.3 3.34e-8 Educational attainment; LUSC cis rs397969 0.596 rs35925051 chr17:19877369 G/A cg13482628 chr17:19912719 NA 0.46 5.71 0.3 2.46e-8 Platelet count; LUSC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg16928487 chr17:17741425 SREBF1 0.46 9.03 0.44 1.4e-17 Total body bone mineral density; LUSC cis rs757081 0.613 rs11024151 chr11:17105730 T/G cg15432903 chr11:17409602 KCNJ11 -0.36 -5.73 -0.3 2.2e-8 Systolic blood pressure; LUSC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg04455712 chr21:45112962 RRP1B 0.46 8.69 0.43 1.67e-16 Mean corpuscular volume; LUSC cis rs10170846 0.800 rs10194743 chr2:223518151 A/G cg25565276 chr2:223520875 FARSB 0.67 10.19 0.49 2.13e-21 Schizophrenia (inflammation and infection response interaction); LUSC cis rs7582180 0.629 rs12989897 chr2:100940998 A/G cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs2500424 chr20:25391969 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.5 -0.34 2.93e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10207060 0.500 rs62183161 chr2:240699856 C/T cg07506560 chr2:240697449 NA 0.46 6.81 0.35 4.45e-11 Obesity-related traits; LUSC cis rs9837602 1.000 rs4279135 chr3:99733096 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.18 0.32 1.82e-9 Breast cancer; LUSC cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg15744005 chr10:104629667 AS3MT 0.29 5.99 0.31 5.29e-9 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.72 -0.39 1.39e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs3741151 0.773 rs79994237 chr11:73147974 T/C cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg21724239 chr8:58056113 NA 0.78 9.78 0.47 5.05e-20 Developmental language disorder (linguistic errors); LUSC cis rs34779708 0.931 rs17591135 chr10:35465190 T/A cg03585969 chr10:35415529 CREM 0.62 9.18 0.45 4.58e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg09184832 chr6:79620586 NA -0.38 -5.83 -0.3 1.3e-8 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.4 6.08 0.32 3.24e-9 Intelligence (multi-trait analysis); LUSC cis rs7945718 0.967 rs10831906 chr11:12783042 C/T cg25843174 chr11:12811716 TEAD1 0.32 7.33 0.37 1.76e-12 Educational attainment (years of education); LUSC cis rs9911578 0.730 rs55759249 chr17:57027135 A/G cg05425664 chr17:57184151 TRIM37 0.62 8.49 0.42 7.11e-16 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg20295408 chr7:1910781 MAD1L1 0.44 6.1 0.32 2.98e-9 Bipolar disorder and schizophrenia; LUSC trans rs2221154 0.648 rs12632615 chr3:28941450 T/C cg16413675 chr16:2520055 NTN3 0.29 6.14 0.32 2.35e-9 Alzheimer's disease; LUSC cis rs500891 0.525 rs1170485 chr6:84038677 G/T cg08257003 chr6:84140564 ME1 0.35 8.36 0.42 1.77e-15 Platelet-derived growth factor BB levels; LUSC cis rs11711311 1.000 rs9848993 chr3:113497914 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.84 0.35 3.9e-11 IgG glycosylation; LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2073300 0.609 rs6137950 chr20:23418722 T/A cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg13390004 chr1:15929781 NA 0.42 7.04 0.36 1.07e-11 Systolic blood pressure; LUSC cis rs11583043 1.000 rs3861734 chr1:101489461 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.91 0.31 8.45e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg03576123 chr11:487126 PTDSS2 -0.96 -10.61 -0.5 7.48e-23 Body mass index; LUSC cis rs17102423 0.594 rs8010213 chr14:65552182 C/T cg11161011 chr14:65562177 MAX -0.72 -11.07 -0.52 1.85e-24 Obesity-related traits; LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg17968037 chr7:100024898 ZCWPW1 -0.42 -6.1 -0.32 2.9e-9 Platelet count; LUSC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg19468946 chr17:37922297 IKZF3 -0.44 -6.93 -0.35 2.22e-11 Self-reported allergy; LUSC cis rs7759001 0.857 rs2143061 chr6:27353705 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.78 0.3 1.73e-8 Glomerular filtration rate (creatinine); LUSC cis rs2070488 0.861 rs2067082 chr3:38438182 C/G cg24069376 chr3:38537580 EXOG 0.49 9.95 0.48 1.39e-20 Electrocardiographic conduction measures; LUSC cis rs6084875 0.840 rs6084850 chr20:4725662 G/A cg07258627 chr20:4721683 PRNT -0.34 -6.16 -0.32 2.05e-9 Systemic lupus erythematosus; LUSC cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg01579765 chr21:45077557 HSF2BP -0.45 -9.4 -0.46 9.19e-19 Mean corpuscular volume; LUSC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg17211192 chr8:82754475 SNX16 -0.59 -8.25 -0.41 3.76e-15 Diastolic blood pressure; LUSC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg13770153 chr20:60521292 NA -0.59 -7.95 -0.4 2.98e-14 Body mass index; LUSC cis rs41271951 0.512 rs11204765 chr1:151016757 G/A cg11822372 chr1:151115635 SEMA6C -0.78 -7.16 -0.36 5.14e-12 Blood protein levels; LUSC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg11812906 chr14:75593930 NEK9 -0.68 -11.61 -0.54 2.04e-26 Height; LUSC cis rs1215050 0.527 rs1214998 chr4:99042878 T/G cg05340658 chr4:99064831 C4orf37 0.45 7.16 0.36 5.31e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7804356 1.000 rs3801836 chr7:26851400 C/T cg03456212 chr7:26904342 SKAP2 -0.54 -6.35 -0.33 7.23e-10 Type 1 diabetes; LUSC cis rs13064411 0.696 rs1486894 chr3:113211513 G/A cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 11.75 0.54 6.26e-27 Alzheimer's disease; LUSC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg00359181 chr2:38893519 GALM -0.53 -6.11 -0.32 2.84e-9 5-HTT brain serotonin transporter levels; LUSC cis rs7089973 0.872 rs3180654 chr10:116615045 T/C cg23260525 chr10:116636907 FAM160B1 0.4 8.26 0.41 3.52e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04691540 chr1:179198414 ABL2 0.43 6.19 0.32 1.76e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3812762 0.868 rs7934519 chr11:8791981 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.34 5.81 0.3 1.45e-8 Hypospadias; LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9359856 0.564 rs17584290 chr6:90467114 T/G cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.2 -0.41 5.08e-15 Bipolar disorder; LUSC cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.34 0.46 1.39e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9815354 0.855 rs73071261 chr3:42003369 C/A cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.04 -0.31 4.14e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7786877 0.521 rs2293767 chr7:100361675 A/G cg16850897 chr7:100343110 ZAN 0.39 6.14 0.32 2.39e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs12410462 0.681 rs74582965 chr1:227610126 C/T cg23173402 chr1:227635558 NA 0.69 7.51 0.38 5.36e-13 Major depressive disorder; LUSC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg04518342 chr5:131593106 PDLIM4 -0.42 -7.77 -0.39 9.64e-14 Breast cancer; LUSC cis rs611744 0.647 rs587340 chr8:109246032 C/A cg18478394 chr8:109455254 TTC35 0.41 6.26 0.32 1.2e-9 Dupuytren's disease; LUSC cis rs2153904 0.609 rs4951254 chr1:205642390 T/C cg23034840 chr1:205782522 SLC41A1 0.56 6.37 0.33 6.33e-10 Prostate-specific antigen levels; LUSC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.8 -0.43 7.62e-17 Axial length; LUSC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg02073558 chr3:44770973 ZNF501 0.57 9.29 0.45 1.97e-18 Depressive symptoms; LUSC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 6.01 0.31 4.85e-9 Tonsillectomy; LUSC cis rs10782582 0.609 rs79835994 chr1:76287508 G/T cg10523679 chr1:76189770 ACADM -0.48 -6.79 -0.35 5.03e-11 Daytime sleep phenotypes; LUSC cis rs7089973 0.604 rs8181444 chr10:116588981 C/T cg25233709 chr10:116636983 FAM160B1 0.37 6.59 0.34 1.69e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -7.44 -0.38 8.62e-13 Chronic sinus infection; LUSC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg13072238 chr3:49761600 GMPPB -0.69 -8.14 -0.41 8.15e-15 Menarche (age at onset); LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg24675658 chr1:53192096 ZYG11B 0.67 11.18 0.52 7.13e-25 Monocyte count; LUSC cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19893071 chr8:145667764 NFKBIL2 -0.74 -6.02 -0.31 4.64e-9 Cognitive performance; LUSC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.68 5.66 0.3 3.25e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs440932 0.757 rs330943 chr8:9021026 G/A cg15556689 chr8:8085844 FLJ10661 0.43 6.09 0.32 3.04e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs7809950 0.678 rs17154040 chr7:107005246 C/T cg23024343 chr7:107201750 COG5 0.66 10.25 0.49 1.26e-21 Coronary artery disease; LUSC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.4 -0.33 5.15e-10 Total body bone mineral density; LUSC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg15445000 chr17:37608096 MED1 0.39 6.68 0.34 1.02e-10 Glomerular filtration rate (creatinine); LUSC cis rs8017423 0.647 rs12589952 chr14:90821364 T/C cg04374321 chr14:90722782 PSMC1 -0.44 -6.61 -0.34 1.54e-10 Mortality in heart failure; LUSC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 2.93e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg07404784 chr11:43665970 NA 0.45 6.65 0.34 1.17e-10 Calcium levels; LUSC cis rs7223966 1.000 rs7214312 chr17:61870863 A/G cg00945038 chr17:61921165 SMARCD2 0.39 5.99 0.31 5.57e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9303401 0.659 rs8074016 chr17:56840587 A/G cg25039879 chr17:56429692 SUPT4H1 0.66 9.12 0.45 7.09e-18 Cognitive test performance; LUSC cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg06877462 chr1:205807181 PM20D1 0.54 10.29 0.49 9.34e-22 Menarche (age at onset); LUSC trans rs4809760 0.901 rs9789783 chr20:48490801 C/A cg15578140 chr7:147718109 MIR548F3;CNTNAP2 -0.25 -6.01 -0.31 4.9e-9 Gut microbiota (beta diversity); LUSC cis rs3736594 0.513 rs3811644 chr2:27802805 A/G cg27432699 chr2:27873401 GPN1 0.67 8.95 0.44 2.57e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg08313168 chr12:7315531 NA 0.46 6.02 0.31 4.48e-9 Lung disease severity in cystic fibrosis; LUSC trans rs61931739 0.890 rs814663 chr12:34106338 C/T cg26384229 chr12:38710491 ALG10B 0.56 8.9 0.44 3.72e-17 Morning vs. evening chronotype; LUSC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg00999904 chr2:3704751 ALLC -0.62 -9.89 -0.48 2.13e-20 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9467773 1.000 rs9467796 chr6:26568411 A/G cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg14019146 chr3:50243930 SLC38A3 0.31 6.85 0.35 3.58e-11 Intelligence (multi-trait analysis); LUSC cis rs7568458 0.709 rs2592551 chr2:85780131 G/A cg02493740 chr2:85810744 VAMP5 -0.54 -9.48 -0.46 4.82e-19 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs208520 0.779 rs208451 chr6:66906155 G/A cg07460842 chr6:66804631 NA -0.96 -12.87 -0.58 4.54e-31 Exhaled nitric oxide output; LUSC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg09365446 chr1:150670422 GOLPH3L 0.55 8.46 0.42 8.5e-16 Tonsillectomy; LUSC cis rs7809950 0.954 rs2712229 chr7:107295326 T/A cg23024343 chr7:107201750 COG5 0.47 7.09 0.36 8.23e-12 Coronary artery disease; LUSC cis rs2050392 0.517 rs602097 chr10:30747546 C/T cg18806716 chr10:30721971 MAP3K8 -0.65 -9.98 -0.48 1.04e-20 Inflammatory bowel disease; LUSC cis rs12618769 0.652 rs1516085 chr2:99232312 G/A cg10123293 chr2:99228465 UNC50 0.43 6.93 0.35 2.19e-11 Bipolar disorder; LUSC cis rs6541297 1.000 rs4846838 chr1:230281618 G/A cg05784532 chr1:230284198 GALNT2 0.65 9.02 0.44 1.46e-17 Coronary artery disease; LUSC cis rs3859192 0.557 rs12602514 chr17:38159745 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.7 12.33 0.56 4.87e-29 White blood cell count; LUSC cis rs1355223 0.583 rs1553757 chr11:34867089 G/A cg24088639 chr11:34937564 PDHX;APIP -0.47 -6.98 -0.36 1.56e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg04455712 chr21:45112962 RRP1B 0.46 8.8 0.43 7.57e-17 Mean corpuscular volume; LUSC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg03582285 chr17:40700314 NA -0.37 -6.32 -0.33 8.58e-10 Colorectal or endometrial cancer; LUSC cis rs1559088 1.000 rs7256328 chr19:33558705 G/C cg27124370 chr19:33622961 WDR88 0.52 6.65 0.34 1.22e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg17143192 chr8:8559678 CLDN23 -0.36 -5.7 -0.3 2.7e-8 Joint mobility (Beighton score); LUSC cis rs76878669 0.561 rs7105015 chr11:66159390 A/G cg24851651 chr11:66362959 CCS -0.38 -5.94 -0.31 6.99e-9 Educational attainment (years of education); LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.57 0.42 3.84e-16 Prudent dietary pattern; LUSC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg14983838 chr19:29218262 NA 0.58 6.8 0.35 4.82e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg26695010 chr11:65641043 EFEMP2 0.42 6.0 0.31 5.07e-9 Breast cancer; LUSC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs8072100 0.967 rs4338849 chr17:45512483 A/G cg25173405 chr17:45401733 C17orf57 -0.4 -6.42 -0.33 4.61e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs208520 1.000 rs208535 chr6:66962286 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.34 -0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs40363 1.000 rs28401 chr16:3515354 C/G cg22508957 chr16:3507546 NAT15 0.84 10.75 0.51 2.4e-23 Tuberculosis; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg24578937 chr1:2090814 PRKCZ -0.46 -9.77 -0.47 5.34e-20 Height; LUSC cis rs8099014 0.861 rs6566974 chr18:56131156 A/G cg12907477 chr18:56117327 MIR122 0.46 7.02 0.36 1.28e-11 Platelet count; LUSC cis rs4766566 0.694 rs3847952 chr12:111746678 T/G cg10833066 chr12:111807467 FAM109A 0.54 10.02 0.48 7.67e-21 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC trans rs991639 0.860 rs1949341 chr3:86204 G/T cg20516845 chr21:43823604 UBASH3A 0.38 6.34 0.33 7.3e-10 Problematic alcohol use in trauma-exposed individuals; LUSC cis rs11098499 0.913 rs10006304 chr4:120124305 A/G cg09307838 chr4:120376055 NA 0.69 9.7 0.47 8.87e-20 Corneal astigmatism; LUSC cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg25258033 chr6:167368657 RNASET2 0.39 6.3 0.33 9.49e-10 Crohn's disease; LUSC cis rs57244997 1.000 rs73026573 chr6:162405119 C/T cg17173639 chr6:162384350 PARK2 -0.64 -6.42 -0.33 4.61e-10 Mosquito bite size; LUSC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg06481639 chr22:41940642 POLR3H -0.51 -5.84 -0.3 1.26e-8 Vitiligo; LUSC cis rs7615316 1.000 rs9882763 chr3:142341308 T/G cg16271453 chr3:142027066 XRN1 -0.36 -6.14 -0.32 2.39e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg22875332 chr1:76189707 ACADM 0.85 14.21 0.61 3.59e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg19717773 chr7:2847554 GNA12 0.33 5.88 0.31 1.02e-8 Height; LUSC trans rs11098499 0.866 rs10518329 chr4:120401835 A/G cg25214090 chr10:38739885 LOC399744 0.47 7.55 0.38 4.11e-13 Corneal astigmatism; LUSC cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg00814883 chr7:100076585 TSC22D4 -0.67 -8.81 -0.43 6.75e-17 Platelet count; LUSC trans rs9393777 0.920 rs41269265 chr6:27425349 T/C cg06606381 chr12:133084897 FBRSL1 -1.03 -9.56 -0.46 2.63e-19 Intelligence (multi-trait analysis); LUSC cis rs61990749 0.597 rs2267759 chr14:78147615 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.41 -0.33 4.99e-10 Fibroblast growth factor basic levels; LUSC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg14829155 chr15:31115871 NA 0.72 10.69 0.51 3.75e-23 Huntington's disease progression; LUSC trans rs7746199 0.736 rs34105070 chr6:27560805 C/T cg01620082 chr3:125678407 NA -0.77 -7.12 -0.36 6.8e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg12432903 chr7:1882776 MAD1L1 -0.37 -6.09 -0.32 3.04e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg00320862 chr3:170588302 RPL22L1 0.4 5.99 0.31 5.45e-9 Schizophrenia (age at onset); LUSC cis rs4400599 0.569 rs10797058 chr1:154200704 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.02 -0.31 4.47e-9 Platelet distribution width; LUSC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg18876405 chr7:65276391 NA -0.7 -12.63 -0.57 3.63e-30 Aortic root size; LUSC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg26597838 chr10:835615 NA 1.01 14.09 0.61 1.02e-35 Eosinophil percentage of granulocytes; LUSC cis rs4242434 0.757 rs7005025 chr8:22519815 G/T cg03733263 chr8:22462867 KIAA1967 0.82 13.56 0.6 1.13e-33 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs1577917 0.958 rs12216074 chr6:86520002 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.88 -0.44 4.32e-17 Response to antipsychotic treatment; LUSC trans rs1459104 0.789 rs28896554 chr11:54812637 C/T cg03929089 chr4:120376271 NA 0.72 6.26 0.32 1.17e-9 Body mass index; LUSC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.3 -0.41 2.62e-15 Lung cancer; LUSC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 14.51 0.62 2.45e-37 Platelet count; LUSC cis rs4631830 0.900 rs10763546 chr10:51536399 C/G cg10326726 chr10:51549505 MSMB -0.38 -6.55 -0.34 2.21e-10 Prostate-specific antigen levels; LUSC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg11764359 chr7:65958608 NA -0.69 -11.1 -0.52 1.4e-24 Aortic root size; LUSC cis rs7640424 0.929 rs327139 chr3:107822481 G/C cg09227934 chr3:107805635 CD47 0.45 7.47 0.38 7.11e-13 Body mass index; LUSC trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2288327 0.643 rs16866334 chr2:179336672 A/G cg11548914 chr2:179343871 FKBP7;PLEKHA3;MIR548N 0.53 6.54 0.34 2.35e-10 Atrial fibrillation; LUSC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9479482 1.000 rs5006620 chr6:150336665 C/T cg25797454 chr6:150327115 RAET1K 0.37 8.49 0.42 7.01e-16 Alopecia areata; LUSC cis rs11112613 0.713 rs58066965 chr12:105952505 C/G cg03607813 chr12:105948248 NA 0.78 11.63 0.54 1.74e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs12618769 0.597 rs2278213 chr2:99136059 A/G cg10123293 chr2:99228465 UNC50 0.44 7.33 0.37 1.77e-12 Bipolar disorder; LUSC cis rs73198271 0.531 rs11985640 chr8:8652504 C/T cg01851573 chr8:8652454 MFHAS1 0.58 7.72 0.39 1.34e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs240993 0.627 rs174389 chr6:111916393 A/C cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.03 -0.31 4.36e-9 Inflammatory skin disease;Psoriasis; LUSC cis rs8017423 0.935 rs2236403 chr14:90736325 C/T cg04374321 chr14:90722782 PSMC1 -0.68 -10.37 -0.49 4.94e-22 Mortality in heart failure; LUSC cis rs6121246 0.559 rs6119728 chr20:30413121 G/A cg13852791 chr20:30311386 BCL2L1 0.9 13.34 0.59 7.48e-33 Mean corpuscular hemoglobin; LUSC trans rs561341 0.883 rs886224 chr17:30229902 T/C cg27661571 chr11:113659931 NA -0.58 -6.45 -0.33 3.92e-10 Hip circumference adjusted for BMI; LUSC cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs1355223 0.583 rs2915179 chr11:34871943 C/T cg11058730 chr11:34937778 PDHX;APIP 0.67 10.68 0.5 4.37e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs3806843 0.735 rs3776129 chr5:140072292 G/A cg19875535 chr5:140030758 IK -0.53 -8.76 -0.43 1.02e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs1160297 0.609 rs1839770 chr2:53104091 G/A cg07782112 chr2:53107842 NA 0.38 6.37 0.33 6.12e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs7605827 0.930 rs4668912 chr2:15610882 C/T cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg10018233 chr7:150070692 REPIN1 0.39 6.74 0.35 6.82e-11 Blood protein levels;Circulating chemerin levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15956273 chr12:65153476 GNS 0.41 6.36 0.33 6.65e-10 Triglycerides; LUSC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg22455342 chr2:225449267 CUL3 0.82 11.2 0.52 6.42e-25 IgE levels in asthmatics (D.p. specific); LUSC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg09034736 chr1:150693464 HORMAD1 0.48 7.0 0.36 1.45e-11 Tonsillectomy; LUSC cis rs6495367 0.872 rs7183818 chr15:79372413 A/G cg17916960 chr15:79447300 NA 0.34 6.05 0.31 3.8e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs7408868 0.611 rs11669982 chr19:15292366 C/T cg14696996 chr19:15285081 NOTCH3 0.63 6.71 0.34 8.55e-11 Pulse pressure; LUSC cis rs11676348 0.808 rs1008563 chr2:219026888 G/A cg00012203 chr2:219082015 ARPC2 -0.57 -8.91 -0.44 3.4e-17 Ulcerative colitis; LUSC cis rs12711979 0.513 rs11676551 chr2:3836782 A/G cg17052675 chr2:3827356 NA -0.35 -5.71 -0.3 2.5e-8 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2070433 1.000 rs11701310 chr21:47962836 G/C cg12379764 chr21:47803548 PCNT 0.81 10.5 0.5 1.71e-22 Lymphocyte counts; LUSC cis rs11098499 0.697 rs10016448 chr4:120298845 A/G cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg24642844 chr7:1081250 C7orf50 -0.45 -7.22 -0.37 3.46e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg26769984 chr7:1090371 C7orf50 0.69 9.75 0.47 6.11e-20 Bronchopulmonary dysplasia; LUSC cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg13256891 chr4:100009986 ADH5 0.41 5.67 0.3 3.14e-8 Alcohol dependence; LUSC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.28e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg05340658 chr4:99064831 C4orf37 0.67 11.5 0.53 5.33e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg03676636 chr4:99064102 C4orf37 0.36 8.01 0.4 1.97e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6987853 0.636 rs6988165 chr8:42351176 C/G cg09913449 chr8:42400586 C8orf40 -0.45 -7.48 -0.38 6.6e-13 Mean corpuscular hemoglobin concentration; LUSC trans rs11098499 0.954 rs12502423 chr4:120424172 A/C cg25214090 chr10:38739885 LOC399744 0.53 7.93 0.4 3.22e-14 Corneal astigmatism; LUSC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg20203395 chr5:56204925 C5orf35 0.53 7.61 0.38 2.75e-13 Coronary artery disease; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg21782813 chr7:2030301 MAD1L1 0.38 6.17 0.32 1.95e-9 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg08859206 chr1:53392774 SCP2 -0.54 -9.57 -0.46 2.45e-19 Monocyte count; LUSC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg21984481 chr17:79567631 NPLOC4 0.52 9.73 0.47 7.15e-20 Eye color traits; LUSC cis rs12291225 0.679 rs34238445 chr11:14315915 C/T cg19336497 chr11:14380999 RRAS2 -0.56 -11.44 -0.53 8.47e-26 Sense of smell; LUSC cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.11 -0.41 9.77e-15 Chronic sinus infection; LUSC cis rs9814567 1.000 rs9813774 chr3:134227100 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.74 -0.6 2.34e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1348850 0.958 rs4528793 chr2:178464271 C/T cg22681709 chr2:178499509 PDE11A -0.48 -8.71 -0.43 1.42e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg16928487 chr17:17741425 SREBF1 -0.42 -8.21 -0.41 4.86e-15 Total body bone mineral density; LUSC cis rs897984 0.762 rs11150601 chr16:30977799 G/A cg02466173 chr16:30829666 NA 0.56 11.22 0.52 5.11e-25 Dementia with Lewy bodies; LUSC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg09997546 chr11:8931473 C11orf17;ST5 -0.36 -7.66 -0.39 2e-13 Hemoglobin concentration; LUSC cis rs877282 1.000 rs34257857 chr10:772993 C/A cg17470449 chr10:769945 NA 0.5 7.0 0.36 1.41e-11 Uric acid levels; LUSC cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg13010199 chr12:38710504 ALG10B -0.67 -11.15 -0.52 9.33e-25 Heart rate; LUSC cis rs6690583 0.623 rs74689037 chr1:85439268 C/T cg11262906 chr1:85462892 MCOLN2 0.7 6.66 0.34 1.16e-10 Serum sulfate level; LUSC trans rs11700980 0.551 rs4999007 chr21:30109259 C/T cg14791747 chr16:20752902 THUMPD1 0.55 5.98 0.31 5.75e-9 QRS complex (12-leadsum); LUSC trans rs11992162 0.551 rs13268217 chr8:11782609 T/A cg14343924 chr8:8086146 FLJ10661 -0.45 -6.23 -0.32 1.43e-9 Monocyte count; LUSC cis rs72781680 1.000 rs55982282 chr2:24188128 G/A cg20701182 chr2:24300061 SF3B14 0.74 7.48 0.38 6.68e-13 Lymphocyte counts; LUSC cis rs317689 0.690 rs7969559 chr12:69655167 A/G cg20891283 chr12:69753455 YEATS4 0.43 6.03 0.31 4.26e-9 Response to diuretic therapy; LUSC trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg21153622 chr11:89784906 NA -0.39 -6.16 -0.32 2.13e-9 HDL cholesterol; LUSC cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg02175503 chr12:58329896 NA 0.61 9.99 0.48 9.8e-21 Intelligence (multi-trait analysis); LUSC cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg15309053 chr8:964076 NA 0.42 8.94 0.44 2.79e-17 Schizophrenia; LUSC cis rs765787 0.530 rs11855435 chr15:45522117 G/A cg25801113 chr15:45476975 SHF 0.34 7.07 0.36 9.18e-12 Uric acid levels; LUSC cis rs926938 0.557 rs6667218 chr1:115238982 G/A cg12756093 chr1:115239321 AMPD1 -0.55 -7.76 -0.39 1.07e-13 Autism; LUSC trans rs7647973 0.626 rs6809879 chr3:49834571 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.6 7.05 0.36 1.03e-11 Menarche (age at onset); LUSC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs8114671 0.836 rs6141526 chr20:33615255 G/T cg07148914 chr20:33460835 GGT7 -0.48 -7.18 -0.37 4.41e-12 Height; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg14159672 chr1:205819179 PM20D1 0.89 16.29 0.67 2.55e-44 Menarche (age at onset); LUSC cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg00530320 chr1:46809349 NSUN4 0.57 8.9 0.44 3.72e-17 Menopause (age at onset); LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.66 0.6 4.84e-34 Platelet count; LUSC cis rs2404602 0.655 rs8028294 chr15:77084877 T/C cg22467129 chr15:76604101 ETFA -0.44 -6.89 -0.35 2.79e-11 Blood metabolite levels; LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg24675658 chr1:53192096 ZYG11B -0.59 -9.23 -0.45 3.2e-18 Monocyte count; LUSC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.39 0.59 5.09e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4971059 0.654 rs4971073 chr1:155113104 G/T cg22049894 chr1:155113146 DPM3 0.38 5.97 0.31 5.92e-9 Breast cancer; LUSC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg25019033 chr10:957182 NA 0.52 6.98 0.36 1.56e-11 Eosinophil percentage of granulocytes; LUSC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg08949735 chr16:89699720 DPEP1 -0.24 -5.88 -0.31 9.96e-9 Vitiligo; LUSC cis rs11583043 1.000 rs11584222 chr1:101480110 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.81 0.3 1.49e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg26395211 chr5:140044315 WDR55 0.45 7.01 0.36 1.33e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs7267979 1.000 rs2258719 chr20:25275843 C/T cg08601574 chr20:25228251 PYGB 0.42 6.31 0.33 8.95e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1044826 0.642 rs6439860 chr3:139175797 A/G cg15131784 chr3:139108705 COPB2 0.38 6.11 0.32 2.76e-9 Obesity-related traits; LUSC trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg15704280 chr7:45808275 SEPT13 -0.58 -7.16 -0.36 5.02e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs6076065 0.723 rs2424545 chr20:23390876 A/G cg11657817 chr20:23433608 CST11 -0.42 -7.89 -0.4 4.24e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg19346786 chr7:2764209 NA -0.45 -7.55 -0.38 4.25e-13 Height; LUSC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg15649852 chr7:65879115 NA -0.41 -5.78 -0.3 1.74e-8 Aortic root size; LUSC cis rs3087591 0.659 rs7218930 chr17:29640204 A/G cg24425628 chr17:29625626 OMG;NF1 0.47 7.09 0.36 8.2e-12 Hip circumference; LUSC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg03806693 chr22:41940476 POLR3H -1.04 -14.65 -0.63 7.01e-38 Vitiligo; LUSC cis rs10186029 0.680 rs10179425 chr2:213978441 T/C cg08319019 chr2:214017104 IKZF2 0.6 8.62 0.43 2.65e-16 Systemic sclerosis; LUSC cis rs9329221 0.870 rs11777976 chr8:10255402 A/G cg27411982 chr8:10470053 RP1L1 -0.51 -8.07 -0.4 1.31e-14 Neuroticism; LUSC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg13393036 chr8:95962371 TP53INP1 -0.45 -9.42 -0.46 7.79e-19 Type 2 diabetes; LUSC cis rs473651 0.935 rs508483 chr2:239339709 T/C cg08773314 chr2:239334832 ASB1 0.42 9.26 0.45 2.63e-18 Multiple system atrophy; LUSC cis rs9463078 0.764 rs976699 chr6:44952852 G/T cg25276700 chr6:44698697 NA -0.29 -5.85 -0.3 1.16e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs10484885 0.775 rs55926724 chr6:90417450 A/C cg13799429 chr6:90582589 CASP8AP2 -0.93 -11.18 -0.52 7.07e-25 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg11062466 chr8:58055876 NA 0.68 7.85 0.39 5.73e-14 Developmental language disorder (linguistic errors); LUSC cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg08873628 chr1:175162347 KIAA0040 0.42 6.04 0.31 4.21e-9 Alcohol dependence; LUSC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg12564285 chr5:131593104 PDLIM4 0.45 8.13 0.41 8.27e-15 Breast cancer; LUSC cis rs9467160 0.871 rs9467168 chr6:24449036 A/G cg20631270 chr6:24437470 GPLD1 0.44 5.76 0.3 1.94e-8 Liver enzyme levels; LUSC cis rs10450586 1.000 rs10450586 chr11:27308483 G/C cg08958251 chr11:27270390 NA 0.35 5.74 0.3 2.15e-8 Total body bone mineral density; LUSC cis rs1865760 1.000 rs3799372 chr6:25922311 A/G cg16482183 chr6:26056742 HIST1H1C 0.44 6.52 0.34 2.67e-10 Height; LUSC cis rs9473147 0.503 rs9473123 chr6:47475339 G/A cg20196966 chr6:47445060 CD2AP 0.42 5.89 0.31 9.61e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.87 0.4 5.04e-14 Prudent dietary pattern; LUSC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg20503657 chr10:835505 NA 1.01 14.35 0.62 1e-36 Eosinophil percentage of granulocytes; LUSC cis rs6690583 0.697 rs10873684 chr1:85522196 T/C cg11262906 chr1:85462892 MCOLN2 -0.57 -7.31 -0.37 2.01e-12 Serum sulfate level; LUSC cis rs9473147 0.516 rs2171089 chr6:47515811 A/G cg12968598 chr6:47444699 CD2AP 0.52 7.96 0.4 2.74e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg09655341 chr17:79618100 PDE6G 0.26 5.9 0.31 9.15e-9 Eye color traits; LUSC cis rs7973719 0.833 rs3825405 chr12:7360143 G/T cg07052231 chr12:7363540 PEX5 0.52 9.11 0.45 8.02e-18 IgG glycosylation; LUSC cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg04450456 chr4:17643702 FAM184B 0.38 6.28 0.33 1.03e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10876993 0.928 rs1689592 chr12:58057773 C/T cg15848620 chr12:58087721 OS9 -0.55 -7.87 -0.4 4.88e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg09877947 chr5:131593287 PDLIM4 0.46 6.41 0.33 5.09e-10 Breast cancer; LUSC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg13939156 chr17:80058883 NA 0.37 7.4 0.38 1.13e-12 Life satisfaction; LUSC trans rs11148252 0.553 rs9536219 chr13:53227301 C/T cg18335740 chr13:41363409 SLC25A15 0.78 14.02 0.61 2.03e-35 Lewy body disease; LUSC cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.47 -8.91 -0.44 3.27e-17 Monocyte percentage of white cells; LUSC cis rs1790761 0.777 rs917570 chr11:67196544 C/G cg24690094 chr11:67383802 NA -0.32 -5.65 -0.3 3.49e-8 Mean corpuscular volume; LUSC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg10755058 chr3:40428713 ENTPD3 0.36 5.92 0.31 8.17e-9 Renal cell carcinoma; LUSC cis rs9788682 0.792 rs35031105 chr15:78772806 C/T cg18825076 chr15:78729989 IREB2 0.44 6.06 0.31 3.73e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg03609598 chr5:56110824 MAP3K1 0.38 5.7 0.3 2.7e-8 Initial pursuit acceleration; LUSC cis rs1506636 0.720 rs2456552 chr7:123441400 A/G cg03229431 chr7:123269106 ASB15 0.45 7.34 0.37 1.67e-12 Plateletcrit;Platelet count; LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.5 0.38 5.7e-13 Bipolar disorder; LUSC cis rs2479724 0.935 rs2025951 chr6:41827193 C/T cg17623882 chr6:41773611 USP49 0.63 10.75 0.51 2.42e-23 Menarche (age at onset); LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg10802521 chr3:52805072 NEK4 -0.54 -8.46 -0.42 8.46e-16 Bipolar disorder; LUSC cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg25233709 chr10:116636983 FAM160B1 0.44 7.96 0.4 2.77e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg06481639 chr22:41940642 POLR3H 0.51 5.85 0.3 1.19e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs11098499 0.954 rs10031483 chr4:120422636 T/C cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg22709100 chr7:91322751 NA 0.42 6.11 0.32 2.82e-9 Breast cancer; LUSC cis rs2115630 0.936 rs8033459 chr15:85253258 C/T cg11189052 chr15:85197271 WDR73 -0.49 -7.32 -0.37 1.91e-12 P wave terminal force; LUSC cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg24642439 chr20:33292090 TP53INP2 -0.48 -7.36 -0.37 1.45e-12 Glomerular filtration rate (creatinine); LUSC trans rs9296661 0.530 rs9349593 chr6:51586771 G/A cg19476788 chr18:77172117 NFATC1 -0.36 -5.97 -0.31 5.99e-9 Weight loss (gastric bypass surgery); LUSC cis rs9467773 1.000 rs1056667 chr6:26510564 T/C cg05738196 chr6:26577821 NA 0.81 15.2 0.64 5.18e-40 Intelligence (multi-trait analysis); LUSC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg00071950 chr4:10020882 SLC2A9 0.66 10.97 0.51 4.07e-24 Bone mineral density; LUSC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg07701084 chr6:150067640 NUP43 0.57 8.84 0.44 5.51e-17 Lung cancer; LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg05855489 chr10:104503620 C10orf26 0.61 8.06 0.4 1.34e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1801251 1.000 rs2675971 chr2:233726154 A/G cg25237894 chr2:233734115 C2orf82 -0.37 -6.97 -0.36 1.72e-11 Coronary artery disease; LUSC cis rs62408225 1.000 rs56106243 chr6:90975990 C/T cg06866423 chr6:90926672 BACH2 0.41 5.92 0.31 7.79e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg18825119 chr6:163149453 PACRG;PARK2 0.59 8.64 0.43 2.43e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2832077 1.000 rs2832077 chr21:30141021 G/A cg08807101 chr21:30365312 RNF160 -0.51 -6.28 -0.32 1.07e-9 Cognitive test performance; LUSC cis rs7264396 0.790 rs2425125 chr20:34330954 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.6 8.95 0.44 2.55e-17 Total cholesterol levels; LUSC cis rs10779751 1.000 rs7524202 chr1:11297762 T/C cg08854313 chr1:11322531 MTOR 0.87 15.22 0.64 4.09e-40 Body mass index; LUSC cis rs3087591 0.922 rs2905799 chr17:29536901 G/A cg24425628 chr17:29625626 OMG;NF1 0.55 8.2 0.41 5.32e-15 Hip circumference; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15905960 chr11:111473361 SIK2 -0.4 -6.02 -0.31 4.58e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7402982 0.647 rs34038360 chr15:99201573 A/C cg03437748 chr15:99193247 IGF1R 0.42 6.03 0.31 4.45e-9 Birth weight; LUSC cis rs6700896 0.931 rs4655743 chr1:66087301 G/C cg04111102 chr1:66153794 NA 0.32 7.07 0.36 9.38e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7843479 0.506 rs7818430 chr8:21798429 C/T cg17168535 chr8:21777572 XPO7 0.85 16.05 0.66 2.34e-43 Mean corpuscular volume; LUSC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg13939156 chr17:80058883 NA -0.33 -6.44 -0.33 4.27e-10 Life satisfaction; LUSC cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg04362960 chr10:104952993 NT5C2 0.66 9.48 0.46 4.91e-19 Arsenic metabolism; LUSC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg06484146 chr7:12443880 VWDE -0.73 -7.34 -0.37 1.64e-12 Coronary artery disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20554926 chr5:162887199 HMMR;NUDCD2 -0.44 -6.86 -0.35 3.38e-11 Triglycerides; LUSC cis rs76878669 0.561 rs905770 chr11:66156765 A/G cg18002602 chr11:66138449 SLC29A2 0.49 8.79 0.43 7.95e-17 Educational attainment (years of education); LUSC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg23000734 chr10:126850823 CTBP2 -0.43 -7.0 -0.36 1.44e-11 Menarche (age at onset); LUSC trans rs7181230 0.813 rs4924417 chr15:40366939 G/C cg22705835 chr10:65332833 REEP3 -0.4 -6.59 -0.34 1.73e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg02807482 chr3:125708958 NA -0.53 -6.68 -0.34 9.76e-11 Blood pressure (smoking interaction); LUSC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg19774624 chr17:42201019 HDAC5 -0.79 -12.73 -0.57 1.57e-30 Total body bone mineral density; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.07 0.52 1.77e-24 Prudent dietary pattern; LUSC cis rs2070488 0.775 rs2300669 chr3:38541318 C/A cg24069376 chr3:38537580 EXOG -0.4 -7.83 -0.39 6.62e-14 Electrocardiographic conduction measures; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg26338869 chr17:61819248 STRADA 0.4 5.75 0.3 1.99e-8 Prudent dietary pattern; LUSC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg06221963 chr1:154839813 KCNN3 -0.44 -8.88 -0.44 4.07e-17 Schizophrenia; LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg02569458 chr12:86230093 RASSF9 0.62 10.47 0.5 2.18e-22 Major depressive disorder; LUSC trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg18230493 chr5:56204884 C5orf35 -0.94 -14.17 -0.61 5.14e-36 Initial pursuit acceleration; LUSC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg14582100 chr15:45693742 SPATA5L1 0.59 10.8 0.51 1.55e-23 Homoarginine levels; LUSC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs6543140 0.964 rs4851593 chr2:103089227 C/T cg09003973 chr2:102972529 NA -0.51 -6.1 -0.32 2.88e-9 Blood protein levels; LUSC cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.524 rs2869024 chr11:47674101 G/A cg20307385 chr11:47447363 PSMC3 -0.44 -6.43 -0.33 4.36e-10 Subjective well-being; LUSC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg12963246 chr6:28129442 ZNF389 0.4 5.99 0.31 5.44e-9 Cardiac Troponin-T levels; LUSC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg11247378 chr22:39784982 NA -0.59 -10.01 -0.48 8.48e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg24250549 chr1:154909240 PMVK 0.63 10.05 0.48 6.22e-21 Prostate cancer; LUSC cis rs924840 0.634 rs2869030 chr15:78711803 A/C cg24631222 chr15:78858424 CHRNA5 0.55 7.49 0.38 6.02e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs460214 0.528 rs6517474 chr21:40023133 G/A cg05519781 chr21:40033154 ERG -0.42 -5.67 -0.3 3.05e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs2463822 1.000 rs2513052 chr11:62108248 C/G cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs394563 0.901 rs448874 chr6:149796967 C/T cg03678062 chr6:149772716 ZC3H12D -0.31 -6.44 -0.33 4.21e-10 Dupuytren's disease; LUSC cis rs9400467 0.508 rs11153294 chr6:111730246 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.98 -0.36 1.56e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs7584330 0.740 rs7586312 chr2:238439389 G/A cg16989719 chr2:238392110 NA -0.36 -6.46 -0.33 3.66e-10 Prostate cancer; LUSC cis rs16949788 0.826 rs74245473 chr15:66708775 C/A cg08120210 chr15:66682733 MAP2K1 -0.6 -5.97 -0.31 6.22e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg11062466 chr8:58055876 NA 0.48 5.96 0.31 6.37e-9 Developmental language disorder (linguistic errors); LUSC cis rs17621444 0.522 rs10886584 chr10:121817282 A/G cg02041677 chr10:121771263 NA -0.33 -6.22 -0.32 1.48e-9 IgG glycosylation; LUSC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12681288 0.862 rs7814231 chr8:1021103 A/G cg15309053 chr8:964076 NA 0.31 6.13 0.32 2.47e-9 Schizophrenia; LUSC cis rs6967385 0.560 rs12673036 chr7:12343463 A/G cg06484146 chr7:12443880 VWDE 0.46 6.83 0.35 4e-11 Response to taxane treatment (placlitaxel); LUSC cis rs6083 0.536 rs4528512 chr15:58852226 A/T cg05156742 chr15:59063176 FAM63B 0.41 6.31 0.33 8.89e-10 Schizophrenia; LUSC cis rs4290604 0.665 rs4432400 chr2:238058938 A/G cg23555395 chr2:238036564 NA -0.52 -6.86 -0.35 3.26e-11 Asthma; LUSC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.82 -0.35 4.29e-11 Total body bone mineral density; LUSC cis rs7089973 0.604 rs11196943 chr10:116598865 T/C cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.23e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.62 -8.25 -0.41 3.65e-15 Systemic lupus erythematosus; LUSC trans rs61931739 0.635 rs1405025 chr12:33908491 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.75 0.39 1.1e-13 Morning vs. evening chronotype; LUSC cis rs1692120 0.669 rs61898510 chr11:61425464 T/C cg19838087 chr11:61442541 NA 0.3 5.94 0.31 7.16e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg25726756 chr21:47582351 C21orf56 0.33 5.65 0.3 3.45e-8 Testicular germ cell tumor; LUSC cis rs2235649 0.833 rs9922139 chr16:1848329 G/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.46 -6.17 -0.32 1.96e-9 Blood metabolite levels; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg07360250 chr5:176830358 F12 0.38 6.37 0.33 6.2e-10 Calcium levels; LUSC cis rs8044995 0.636 rs117761434 chr16:68254196 G/A cg09835421 chr16:68378352 PRMT7 -0.59 -6.31 -0.33 8.82e-10 Schizophrenia; LUSC cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.69 -0.3 2.75e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.22 0.49 1.67e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg11752832 chr7:134001865 SLC35B4 0.6 9.54 0.46 3.19e-19 Mean platelet volume; LUSC cis rs12980942 1.000 rs4456618 chr19:41813957 G/C cg25627403 chr19:41769009 HNRNPUL1 0.57 6.24 0.32 1.31e-9 Coronary artery disease; LUSC cis rs6754311 0.593 rs55825471 chr2:136526981 T/A cg07169764 chr2:136633963 MCM6 -0.59 -7.81 -0.39 7.72e-14 Mosquito bite size; LUSC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg24250549 chr1:154909240 PMVK 0.65 10.87 0.51 9.05e-24 Prostate cancer; LUSC cis rs6964587 0.610 rs7788951 chr7:91468765 A/T cg17063962 chr7:91808500 NA 0.54 8.71 0.43 1.47e-16 Breast cancer; LUSC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg03433033 chr1:76189801 ACADM -0.81 -13.1 -0.58 6.17e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4478858 0.735 rs6679360 chr1:31817936 G/T cg00250761 chr1:31883323 NA -0.37 -9.16 -0.45 5.22e-18 Alcohol dependence; LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg00166722 chr3:10149974 C3orf24 -0.65 -9.5 -0.46 4.23e-19 Alzheimer's disease; LUSC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg12963246 chr6:28129442 ZNF389 0.55 7.85 0.39 5.77e-14 Depression; LUSC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg03388025 chr16:89894329 SPIRE2 0.33 6.85 0.35 3.48e-11 Vitiligo; LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg02951883 chr7:2050386 MAD1L1 -0.5 -8.93 -0.44 2.9e-17 Bipolar disorder and schizophrenia; LUSC cis rs12586317 0.620 rs58320987 chr14:35587726 T/C cg16230307 chr14:35515116 FAM177A1 0.77 10.17 0.49 2.41e-21 Psoriasis; LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg24829409 chr8:58192753 C8orf71 -0.59 -6.25 -0.32 1.22e-9 Developmental language disorder (linguistic errors); LUSC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg22907277 chr7:1156413 C7orf50 0.7 10.26 0.49 1.21e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.07 -0.32 3.43e-9 Neutrophil percentage of white cells; LUSC cis rs3106136 0.933 rs34383543 chr4:95163792 T/C cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.08 -0.32 3.26e-9 Capecitabine sensitivity; LUSC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg06112835 chr11:68658793 MRPL21 0.52 7.75 0.39 1.12e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7918232 0.627 rs10829165 chr10:27319465 A/G cg14442939 chr10:27389572 ANKRD26 0.54 7.01 0.36 1.31e-11 Breast cancer; LUSC cis rs17270561 0.553 rs6456696 chr6:25741408 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg23467222 chr17:79926018 NA 0.39 6.03 0.31 4.3e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1577917 0.958 rs2660576 chr6:86651603 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs745570 1.000 rs745571 chr17:77781387 T/C cg04986373 chr17:77768687 CBX8 0.38 7.43 0.38 8.93e-13 Breast cancer; LUSC cis rs7739264 0.563 rs9465516 chr6:19771998 A/C cg02404759 chr6:19790362 NA -0.42 -6.67 -0.34 1.07e-10 Endometriosis; LUSC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4664308 1.000 rs10929965 chr2:160906931 C/T cg03641300 chr2:160917029 PLA2R1 0.67 11.19 0.52 6.83e-25 Idiopathic membranous nephropathy; LUSC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg16989086 chr20:62203971 PRIC285 0.46 6.42 0.33 4.69e-10 Glioblastoma; LUSC cis rs7296418 0.961 rs1790106 chr12:123591596 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.88 -0.35 2.94e-11 Platelet count; LUSC trans rs62238980 0.614 rs117161237 chr22:32501630 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -5.96 -0.31 6.37e-9 Childhood ear infection; LUSC cis rs2412208 0.509 rs7546792 chr1:7124346 C/T cg20434152 chr1:7120926 CAMTA1 -0.37 -7.71 -0.39 1.48e-13 Survival in sporadic amyotrophic lateral sclerosis; LUSC cis rs9616064 0.853 rs7284865 chr22:46996529 C/T cg05621596 chr22:47072043 GRAMD4 -0.44 -6.89 -0.35 2.73e-11 Urate levels in obese individuals; LUSC cis rs1881797 1.000 rs55852476 chr1:247696173 G/A cg14830002 chr1:247616686 OR2B11 0.51 7.27 0.37 2.59e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs6982240 0.569 rs6992286 chr8:142279412 G/A cg27411547 chr8:142287226 NA -0.48 -8.51 -0.42 6.05e-16 Tonsillectomy; LUSC trans rs4718428 1.000 rs4718421 chr7:66350300 C/T cg18876405 chr7:65276391 NA 0.48 7.39 0.37 1.2e-12 Corneal structure; LUSC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 6.06 0.31 3.7e-9 Electroencephalogram traits; LUSC trans rs9860340 0.730 rs4859087 chr3:87636245 C/T cg03644585 chr7:884825 UNC84A -0.42 -5.99 -0.31 5.32e-9 Electroencephalographic traits in alcoholism; LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg24397884 chr7:158709396 WDR60 0.62 9.57 0.46 2.48e-19 Height; LUSC cis rs2652834 0.687 rs35963767 chr15:63397601 G/A cg05507819 chr15:63340323 TPM1 0.55 7.07 0.36 8.99e-12 HDL cholesterol; LUSC cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6908843 0.532 rs79555858 chr6:166666497 G/A cg06878426 chr6:166666287 NA 0.45 6.38 0.33 5.91e-10 Macrophage inflammatory protein 1b levels; LUSC trans rs72674100 0.867 rs75247520 chr4:97980121 C/T cg09670535 chr1:18959427 PAX7 -0.64 -6.12 -0.32 2.68e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs881375 0.933 rs7021206 chr9:123684157 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.46 -6.72 -0.35 7.72e-11 Rheumatoid arthritis; LUSC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.08 -0.36 8.5e-12 Major depressive disorder; LUSC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs722599 0.683 rs17102847 chr14:75324780 A/G cg08847533 chr14:75593920 NEK9 -0.46 -6.52 -0.34 2.67e-10 IgG glycosylation; LUSC cis rs6424115 0.830 rs6663474 chr1:24199642 G/A cg10978503 chr1:24200527 CNR2 0.54 13.24 0.59 1.85e-32 Immature fraction of reticulocytes; LUSC cis rs9311676 0.656 rs55668308 chr3:58388453 C/T cg13750441 chr3:58318267 PXK 0.35 6.72 0.35 7.86e-11 Systemic lupus erythematosus; LUSC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg00310523 chr12:86230176 RASSF9 -0.5 -9.44 -0.46 6.49e-19 Major depressive disorder; LUSC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg26924012 chr15:45694286 SPATA5L1 1.13 20.81 0.75 2.85e-62 Homoarginine levels; LUSC cis rs7075426 0.789 rs6586011 chr10:88213604 A/G cg07322936 chr10:88137208 NA -0.46 -6.65 -0.34 1.17e-10 Migraine without aura; LUSC cis rs3790515 1.000 rs3790515 chr1:151786372 A/G cg07092448 chr1:151763213 TDRKH 0.86 7.18 0.37 4.43e-12 Depressive symptoms (SSRI exposure interaction); LUSC cis rs73206853 0.620 rs73194027 chr12:111144317 C/A cg12870014 chr12:110450643 ANKRD13A 0.67 6.52 0.34 2.64e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs807669 0.548 rs885978 chr22:19198226 A/G cg02655711 chr22:19163373 SLC25A1 0.66 12.03 0.55 6.18e-28 Metabolite levels; LUSC trans rs561341 0.943 rs508566 chr17:30289861 G/C cg27661571 chr11:113659931 NA -0.66 -7.44 -0.38 8.49e-13 Hip circumference adjusted for BMI; LUSC cis rs911119 0.913 rs6036463 chr20:23578940 A/T cg16589663 chr20:23618590 CST3 -0.63 -7.66 -0.39 2.04e-13 Chronic kidney disease; LUSC cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg09877947 chr5:131593287 PDLIM4 0.41 6.79 0.35 5.11e-11 Blood metabolite levels; LUSC cis rs600231 0.708 rs2957268 chr11:65245816 A/G cg21890820 chr11:65308645 LTBP3 0.5 7.41 0.38 1.02e-12 Bone mineral density; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg04267008 chr7:1944627 MAD1L1 -0.61 -9.37 -0.46 1.12e-18 Bipolar disorder and schizophrenia; LUSC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg03605463 chr16:89740564 NA 0.59 9.43 0.46 6.97e-19 Vitiligo; LUSC cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg00409905 chr10:38381863 ZNF37A -0.36 -6.12 -0.32 2.6e-9 Extrinsic epigenetic age acceleration; LUSC trans rs7726839 0.540 rs55929359 chr5:595956 C/G cg25482853 chr8:67687455 SGK3 1.12 16.14 0.66 1.01e-43 Obesity-related traits; LUSC cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg00074818 chr8:8560427 CLDN23 0.59 9.95 0.48 1.32e-20 Obesity-related traits; LUSC cis rs11098499 0.863 rs2170276 chr4:120485824 A/C cg09307838 chr4:120376055 NA 0.75 10.74 0.51 2.58e-23 Corneal astigmatism; LUSC cis rs7647973 0.925 rs7429661 chr3:49228800 G/A cg07636037 chr3:49044803 WDR6 0.66 8.08 0.4 1.17e-14 Menarche (age at onset); LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg16405210 chr4:1374714 KIAA1530 0.53 8.19 0.41 5.43e-15 Obesity-related traits; LUSC cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs35123781 0.502 rs261532 chr5:138949362 A/C cg00976381 chr5:138713954 SLC23A1 0.43 6.27 0.32 1.12e-9 Schizophrenia; LUSC cis rs477692 0.673 rs511361 chr10:131365052 C/T cg11019008 chr10:131425282 MGMT 0.43 6.19 0.32 1.79e-9 Response to temozolomide; LUSC cis rs3760982 1.000 rs4802200 chr19:44289518 G/A cg11993925 chr19:44307056 LYPD5 0.29 6.32 0.33 8.54e-10 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs8077577 0.945 rs11653988 chr17:18088833 C/T cg16794390 chr17:18148240 FLII 0.4 5.68 0.3 2.96e-8 Obesity-related traits; LUSC cis rs4595586 0.525 rs7970652 chr12:39374873 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.08e-9 Morning vs. evening chronotype; LUSC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 5.87 0.31 1.07e-8 Personality dimensions; LUSC cis rs9473147 0.543 rs9473119 chr6:47450618 G/A cg02130027 chr6:47444894 CD2AP 0.35 5.67 0.3 3.01e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs3020736 0.500 rs6002618 chr22:42507859 G/C cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs877282 0.853 rs7092652 chr10:756109 G/A cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg16339924 chr4:17578868 LAP3 0.6 9.43 0.46 7.3e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9311676 0.632 rs11714389 chr3:58447299 C/T cg26110898 chr3:58419937 PDHB 0.41 6.97 0.36 1.75e-11 Systemic lupus erythematosus; LUSC cis rs9875589 0.509 rs1601870 chr3:14024162 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 6.87 0.35 3.17e-11 Ovarian reserve; LUSC cis rs7122539 0.646 rs543191 chr11:66583779 T/G cg18002602 chr11:66138449 SLC29A2 -0.36 -6.44 -0.33 4.08e-10 HIV-1 susceptibility; LUSC cis rs1971762 0.602 rs4759283 chr12:54079243 C/T cg23533419 chr12:54090519 NA -0.37 -6.01 -0.31 4.8e-9 Height; LUSC cis rs12310956 0.532 rs11052935 chr12:33970946 C/T cg06521331 chr12:34319734 NA -0.47 -7.53 -0.38 4.93e-13 Morning vs. evening chronotype; LUSC cis rs4930103 0.935 rs4930098 chr11:2020955 G/C cg23202291 chr11:1979235 NA 0.39 6.1 0.32 2.96e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg07395648 chr5:131743802 NA -0.35 -5.77 -0.3 1.8e-8 Blood metabolite levels; LUSC cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg24642439 chr20:33292090 TP53INP2 -0.47 -6.85 -0.35 3.67e-11 Glomerular filtration rate (creatinine); LUSC cis rs41271473 0.948 rs12082771 chr1:228830777 C/T cg16512390 chr1:228756714 NA 0.57 6.88 0.35 2.93e-11 Chronic lymphocytic leukemia; LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.17 -0.37 4.97e-12 Bipolar disorder; LUSC cis rs9925964 0.933 rs2359612 chr16:31103796 A/G cg02466173 chr16:30829666 NA -0.36 -6.41 -0.33 4.94e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg01475377 chr6:109611718 NA -0.43 -7.8 -0.39 7.74e-14 Reticulocyte fraction of red cells; LUSC cis rs3771570 0.892 rs59715783 chr2:242366262 C/T cg21155796 chr2:242212141 HDLBP 0.62 6.69 0.34 9.6e-11 Prostate cancer; LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs9886651 0.935 rs28660151 chr8:128803578 A/T cg07795030 chr8:128802207 NA -0.33 -6.0 -0.31 5.2e-9 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg09455208 chr3:40491958 NA -0.56 -9.43 -0.46 6.94e-19 Renal cell carcinoma; LUSC cis rs2859741 0.967 rs522481 chr1:37488337 C/T cg09363841 chr1:37513479 NA -0.39 -7.71 -0.39 1.43e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg01657329 chr11:68192670 LRP5 -0.45 -6.68 -0.34 1.03e-10 Total body bone mineral density; LUSC cis rs4911259 0.552 rs6058925 chr20:31465374 G/A cg13636640 chr20:31349939 DNMT3B -0.81 -15.5 -0.65 3.33e-41 Inflammatory bowel disease; LUSC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.67 0.39 1.9e-13 Breast cancer; LUSC cis rs8017423 0.872 rs7492857 chr14:90684867 T/G cg14092571 chr14:90743983 NA 0.36 5.89 0.31 9.22e-9 Mortality in heart failure; LUSC cis rs2204008 0.807 rs4123933 chr12:37973539 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.92 0.51 5.92e-24 Bladder cancer; LUSC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.51 0.42 5.82e-16 Height; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03157738 chr19:11308118 KANK2 0.45 6.61 0.34 1.51e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg25456477 chr12:86230367 RASSF9 -0.32 -5.66 -0.3 3.29e-8 Major depressive disorder; LUSC trans rs4596713 0.538 rs11145484 chr9:71769857 G/C cg25283916 chr1:242222868 NA -0.31 -6.36 -0.33 6.58e-10 Headache; LUSC cis rs12594515 0.967 rs71405295 chr15:45988921 T/C cg06207120 chr15:45996521 NA 0.39 6.09 0.32 3.08e-9 Waist circumference;Weight; LUSC cis rs28829049 0.597 rs2066002 chr1:19504300 G/A cg13387374 chr1:19411106 UBR4 0.45 6.23 0.32 1.39e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7615952 0.515 rs7630575 chr3:125682330 A/G cg05084668 chr3:125655381 ALG1L -0.65 -10.15 -0.49 2.84e-21 Blood pressure (smoking interaction); LUSC cis rs858239 0.601 rs6948469 chr7:23174766 G/T cg23682824 chr7:23144976 KLHL7 0.39 5.7 0.3 2.59e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg02475777 chr4:1388615 CRIPAK 0.43 6.39 0.33 5.68e-10 Obesity-related traits; LUSC cis rs7582180 0.602 rs7585582 chr2:100998030 G/C cg12002119 chr2:101014098 CHST10 0.35 5.88 0.31 9.71e-9 Intelligence (multi-trait analysis); LUSC cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg15073853 chr19:18549131 ISYNA1 -0.33 -5.92 -0.31 8.14e-9 Breast cancer; LUSC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg05738196 chr6:26577821 NA 0.47 6.8 0.35 4.7e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs11098499 0.779 rs80242894 chr4:120375752 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.39 0.33 5.72e-10 Corneal astigmatism; LUSC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg02753203 chr1:228287806 NA 0.7 12.45 0.56 1.71e-29 Diastolic blood pressure; LUSC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg25767906 chr1:53392781 SCP2 -0.53 -9.61 -0.47 1.84e-19 Monocyte count; LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg17366294 chr4:99064904 C4orf37 0.54 9.54 0.46 3.1400000000000002e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2282300 0.739 rs7926465 chr11:30333016 C/T cg25418670 chr11:30344373 C11orf46 0.64 9.23 0.45 3.29e-18 Morning vs. evening chronotype; LUSC cis rs10782582 0.593 rs17585530 chr1:76134990 G/A cg03433033 chr1:76189801 ACADM -0.45 -6.7 -0.34 9.03e-11 Daytime sleep phenotypes; LUSC cis rs4478858 0.735 rs11590120 chr1:31792324 A/G cg00250761 chr1:31883323 NA -0.37 -8.97 -0.44 2.17e-17 Alcohol dependence; LUSC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg13628971 chr7:2884303 GNA12 0.44 6.44 0.33 4.09e-10 Height; LUSC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg04450456 chr4:17643702 FAM184B 0.36 6.06 0.31 3.7e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1595825 1.000 rs2165237 chr2:198875003 C/T cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg11244672 chr19:19639970 YJEFN3 -0.58 -7.38 -0.37 1.27e-12 Bipolar disorder; LUSC cis rs7804356 1.000 rs3823936 chr7:26853830 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.16 -0.32 2.1e-9 Type 1 diabetes; LUSC cis rs3809566 1.000 rs3809566 chr15:63333724 A/G cg05507819 chr15:63340323 TPM1 0.64 8.83 0.43 6.06e-17 Platelet count; LUSC cis rs6961069 0.806 rs10480808 chr7:80250122 A/T cg04458919 chr7:80252533 CD36 -0.35 -6.29 -0.33 1e-9 Platelet count; LUSC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg13114125 chr14:105738426 BRF1 -0.89 -15.46 -0.65 4.96e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg04369109 chr6:150039330 LATS1 -0.55 -8.07 -0.4 1.24e-14 Lung cancer; LUSC cis rs2348418 0.864 rs11049716 chr12:28717646 A/G cg13890972 chr12:28721907 NA -0.34 -5.93 -0.31 7.72e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs1983170 0.935 rs578155 chr1:91976541 G/A cg21854759 chr1:92012499 NA -0.43 -5.71 -0.3 2.53e-8 Eosinophil percentage of white cells; LUSC cis rs4363385 0.510 rs11577384 chr1:152899728 C/T cg00922841 chr1:152955080 SPRR1A -0.37 -6.01 -0.31 4.92e-9 Inflammatory skin disease; LUSC cis rs1729951 0.575 rs747842 chr3:136703121 A/C cg12473912 chr3:136751656 NA 0.4 7.17 0.37 4.99e-12 Neuroticism; LUSC cis rs9486719 1.000 rs1303852 chr6:96864523 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.99 0.4 2.15e-14 Prudent dietary pattern; LUSC cis rs3806933 0.500 rs10491423 chr5:110453977 C/A cg04022379 chr5:110408740 TSLP 0.64 9.6 0.47 1.9e-19 Eosinophilic esophagitis; LUSC cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.49 8.06 0.4 1.41e-14 IgG glycosylation; LUSC cis rs11608355 0.545 rs12822974 chr12:109909154 G/T cg05360138 chr12:110035743 NA 0.88 11.29 0.53 2.95e-25 Neuroticism; LUSC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg16049864 chr8:95962084 TP53INP1 -0.68 -12.93 -0.58 2.71e-31 Type 2 diabetes; LUSC cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.68 -0.43 1.81e-16 Body mass index; LUSC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg14530993 chr4:882597 GAK 0.69 7.12 0.36 6.64e-12 Intelligence (multi-trait analysis); LUSC cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg13902645 chr11:5959945 NA -0.54 -7.52 -0.38 5.04e-13 DNA methylation (variation); LUSC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg19230755 chr7:65878503 NA -0.43 -6.04 -0.31 4.06e-9 Aortic root size; LUSC cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.47 0.33 3.45e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs11098499 0.818 rs10008791 chr4:120431469 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.61 0.34 1.48e-10 Corneal astigmatism; LUSC cis rs11711311 1.000 rs9830978 chr3:113455940 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC trans rs2228479 0.850 rs17226512 chr16:89839976 T/C cg24644049 chr4:85504048 CDS1 0.86 7.56 0.38 3.83e-13 Skin colour saturation; LUSC cis rs929354 0.772 rs10228145 chr7:157007337 A/G cg17757837 chr7:157058334 UBE3C 0.78 12.46 0.56 1.56e-29 Body mass index; LUSC cis rs765787 0.530 rs11636404 chr15:45535861 C/G cg25801113 chr15:45476975 SHF 0.34 6.92 0.35 2.36e-11 Uric acid levels; LUSC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg25039879 chr17:56429692 SUPT4H1 0.5 7.04 0.36 1.08e-11 Cognitive test performance; LUSC cis rs6484504 0.600 rs2616815 chr11:31327316 C/T cg26647111 chr11:31128758 NA 0.4 5.7 0.3 2.69e-8 Red blood cell count; LUSC cis rs977987 0.806 rs4146809 chr16:75415775 A/G cg04384234 chr16:75411784 CFDP1 0.41 6.63 0.34 1.37e-10 Dupuytren's disease; LUSC cis rs6138458 1.000 rs227615 chr20:24908721 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.25 0.71 4.21e-52 Blood protein levels; LUSC cis rs11098499 0.955 rs4145951 chr4:120155817 A/G cg09307838 chr4:120376055 NA 0.69 10.01 0.48 8.32e-21 Corneal astigmatism; LUSC cis rs9311676 0.632 rs6785572 chr3:58361517 A/G cg26110898 chr3:58419937 PDHB -0.4 -6.65 -0.34 1.19e-10 Systemic lupus erythematosus; LUSC cis rs1577917 0.958 rs3857480 chr6:86535149 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg00612595 chr21:47717864 NA 0.39 5.69 0.3 2.74e-8 Testicular germ cell tumor; LUSC cis rs6665290 0.904 rs1045287 chr1:227178962 C/T cg10327440 chr1:227177885 CDC42BPA 1.23 41.16 0.91 7.42e-133 Myeloid white cell count; LUSC cis rs7191700 0.712 rs7187741 chr16:11433103 C/G cg00044050 chr16:11439710 C16orf75 -0.68 -12.13 -0.55 2.59e-28 Multiple sclerosis; LUSC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg13607699 chr17:42295918 UBTF 0.49 7.64 0.39 2.39e-13 Total body bone mineral density; LUSC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg09455208 chr3:40491958 NA -0.5 -9.25 -0.45 2.78e-18 Renal cell carcinoma; LUSC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg14583973 chr4:3374767 RGS12 0.37 8.17 0.41 6.56e-15 Serum sulfate level; LUSC cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.52 0.69 3.21e-49 Chronic sinus infection; LUSC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg03732007 chr1:2071316 PRKCZ 0.55 9.97 0.48 1.12e-20 Height; LUSC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg19052272 chr2:3704530 ALLC -0.49 -8.19 -0.41 5.6e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.37 0.37 1.35e-12 Bipolar disorder; LUSC cis rs1048238 0.506 rs848212 chr1:16263452 A/G cg22431228 chr1:16359049 CLCNKA 0.4 8.53 0.42 5.25e-16 Systolic blood pressure; LUSC trans rs1005277 0.540 rs7903942 chr10:37929276 C/T cg17830980 chr10:43048298 ZNF37B 0.42 6.61 0.34 1.5e-10 Extrinsic epigenetic age acceleration; LUSC cis rs3540 0.512 rs8033595 chr15:91083353 G/A cg10434728 chr15:90938212 IQGAP1 -0.45 -9.43 -0.46 7.25e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg03461704 chr1:205818484 PM20D1 0.36 5.82 0.3 1.39e-8 Menarche (age at onset); LUSC cis rs968567 0.501 rs174553 chr11:61575158 A/G cg19610905 chr11:61596333 FADS2 -0.55 -8.26 -0.41 3.54e-15 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg11057378 chr10:81107060 PPIF 0.37 6.32 0.33 8.36e-10 Height; LUSC cis rs9341808 0.739 rs4706831 chr6:81007699 T/C cg08355045 chr6:80787529 NA 0.56 9.89 0.48 2.07e-20 Sitting height ratio; LUSC cis rs6906287 0.559 rs2798322 chr6:118991605 G/T cg21191810 chr6:118973309 C6orf204 0.33 6.02 0.31 4.7e-9 Electrocardiographic conduction measures; LUSC cis rs6912958 0.630 rs9450726 chr6:88236728 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -5.94 -0.31 7.12e-9 Monocyte percentage of white cells; LUSC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg21862992 chr11:68658383 NA 0.51 7.73 0.39 1.28e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04652621 chr7:150671807 KCNH2 -0.53 -6.82 -0.35 4.36e-11 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.06e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7712401 0.511 rs30068 chr5:122293609 C/T cg19077854 chr5:122220652 SNX24 0.39 8.65 0.43 2.17e-16 Mean platelet volume; LUSC cis rs16867321 0.639 rs12466864 chr2:181441417 C/G cg23363182 chr2:181467187 NA 0.57 9.14 0.45 6.28e-18 Obesity; LUSC trans rs8105895 0.735 rs17554694 chr19:22317148 A/G cg05197062 chr11:11642011 GALNTL4 0.5 6.46 0.33 3.8e-10 Body mass index (change over time); LUSC cis rs6977660 1.000 rs6959591 chr7:19821824 A/G cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs10782582 0.593 rs11802717 chr1:76124648 C/T cg22875332 chr1:76189707 ACADM -0.42 -6.24 -0.32 1.35e-9 Daytime sleep phenotypes; LUSC cis rs12980942 0.872 rs12976536 chr19:41799886 T/A cg25627403 chr19:41769009 HNRNPUL1 0.62 6.62 0.34 1.41e-10 Coronary artery disease; LUSC cis rs10484885 0.553 rs17707975 chr6:90622318 T/G cg13799429 chr6:90582589 CASP8AP2 -0.57 -5.7 -0.3 2.6e-8 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3020736 0.500 rs2413672 chr22:42513261 C/T cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs308403 0.509 rs7690409 chr4:123666757 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.92 16.06 0.66 2.01e-43 Blood protein levels; LUSC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2692947 0.655 rs60090597 chr2:96406266 G/A cg22654517 chr2:96458247 NA 0.36 6.77 0.35 5.86e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs5770917 1.000 rs115743514 chr22:51011933 T/C cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.59 -5.7 -0.3 2.67e-8 Narcolepsy; LUSC trans rs2243480 1.000 rs7794661 chr7:65389730 T/C cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs5769707 0.632 rs5770601 chr22:50021903 A/G cg20744362 chr22:50050164 C22orf34 0.41 7.58 0.38 3.34e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg03060546 chr3:49711283 APEH -0.69 -10.24 -0.49 1.42e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg12403142 chr1:92012408 NA -0.38 -6.15 -0.32 2.22e-9 Breast cancer; LUSC cis rs1160297 0.576 rs6754423 chr2:53096730 G/A cg07782112 chr2:53107842 NA 0.43 7.0 0.36 1.42e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.58 6.06 0.31 3.59e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg14343924 chr8:8086146 FLJ10661 0.43 5.97 0.31 6.15e-9 Mood instability; LUSC cis rs5769765 0.671 rs138833 chr22:50178917 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.42 6.6 0.34 1.65e-10 Schizophrenia; LUSC cis rs9325144 0.560 rs1825802 chr12:38650341 C/T cg13010199 chr12:38710504 ALG10B -0.53 -8.1 -0.41 1.03e-14 Morning vs. evening chronotype; LUSC cis rs3806843 1.000 rs3822346 chr5:140187322 C/T cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs3784262 1.000 rs12907038 chr15:58244032 C/G cg12031962 chr15:58353849 ALDH1A2 -0.33 -6.09 -0.32 3.08e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg03188948 chr7:1209495 NA 0.62 6.56 0.34 2.03e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs12478296 0.786 rs6721704 chr2:242994923 A/G cg18288967 chr1:45987694 PRDX1 0.52 5.94 0.31 7e-9 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04902826 chr10:105677453 OBFC1 0.46 6.63 0.34 1.34e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg23711669 chr6:146136114 FBXO30 0.87 16.14 0.66 1e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.534 rs11052984 chr12:34045904 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.88 0.51 8.52e-24 Morning vs. evening chronotype; LUSC trans rs11165623 0.792 rs12123543 chr1:96964549 T/C cg10631902 chr5:14652156 NA -0.48 -7.33 -0.37 1.77e-12 Hip circumference;Waist circumference; LUSC cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg06784218 chr1:46089804 CCDC17 0.53 10.68 0.5 4.27e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9517313 0.591 rs9554480 chr13:99221138 T/A cg07423050 chr13:99094983 FARP1 -0.52 -9.38 -0.46 1.03e-18 Neuroticism; LUSC cis rs9322193 0.886 rs4870049 chr6:150158194 G/T cg04369109 chr6:150039330 LATS1 -0.57 -8.32 -0.41 2.32e-15 Lung cancer; LUSC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg21862992 chr11:68658383 NA 0.52 8.08 0.4 1.17e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs17685 0.884 rs8565 chr7:75630274 T/C cg19862616 chr7:65841803 NCRNA00174 -1.0 -15.22 -0.64 4.31e-40 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -16.89 -0.68 1.11e-46 Monocyte count; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.14 0.45 6.03e-18 Prudent dietary pattern; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.62e-9 Monocyte count; LUSC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg23262073 chr20:60523788 NA -0.42 -5.84 -0.3 1.21e-8 Body mass index; LUSC trans rs61931739 0.500 rs11053189 chr12:34433455 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.63 0.65 9.84e-42 Morning vs. evening chronotype; LUSC cis rs9534288 0.783 rs1126366 chr13:46633148 C/G cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg00750074 chr16:89608354 SPG7 -0.46 -7.97 -0.4 2.52e-14 Multiple myeloma (IgH translocation); LUSC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg09365446 chr1:150670422 GOLPH3L -0.52 -7.55 -0.38 4.32e-13 Blood protein levels; LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg14895029 chr7:2775587 GNA12 -0.39 -6.06 -0.31 3.6e-9 Height; LUSC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg21782813 chr7:2030301 MAD1L1 -0.51 -9.08 -0.44 9.75e-18 Bipolar disorder and schizophrenia; LUSC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 -0.68 -8.39 -0.42 1.43e-15 Lung function (FEV1/FVC); LUSC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.48 -0.46 4.74e-19 Chronic sinus infection; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg00684032 chr4:1343700 KIAA1530 0.37 6.53 0.34 2.38e-10 Obesity-related traits; LUSC cis rs55665837 1.000 rs10832264 chr11:14459982 T/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 6.93e-13 Vitamin D levels; LUSC cis rs1577917 0.917 rs12665464 chr6:86574133 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.93 -0.44 2.88e-17 Response to antipsychotic treatment; LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.88 0.48 2.3e-20 Bipolar disorder; LUSC trans rs7939886 0.920 rs17150096 chr11:55902996 C/T cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs6599077 0.853 rs9832553 chr3:40097408 C/T cg13683864 chr3:40499215 RPL14 -0.58 -7.15 -0.36 5.65e-12 Sleep-related phenotypes; LUSC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg14343924 chr8:8086146 FLJ10661 -0.43 -6.07 -0.32 3.5e-9 Mood instability; LUSC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.98 -0.4 2.36e-14 Personality dimensions; LUSC cis rs4889911 0.544 rs1294081 chr17:77829864 T/C cg00646381 chr17:77835854 NA 0.58 9.22 0.45 3.52e-18 Electroencephalogram traits; LUSC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg02038168 chr22:39784481 NA -0.5 -8.16 -0.41 6.77e-15 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -13.72 -0.6 2.67e-34 Height; LUSC trans rs7824557 0.628 rs2572387 chr8:11204165 C/T cg15556689 chr8:8085844 FLJ10661 0.51 7.37 0.37 1.34e-12 Retinal vascular caliber; LUSC cis rs4917300 1.000 rs2220696 chr8:143118812 C/G cg25363559 chr8:143086065 NA 0.29 6.19 0.32 1.75e-9 Amyotrophic lateral sclerosis; LUSC cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg13010199 chr12:38710504 ALG10B 0.67 10.3 0.49 9.03e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg25072359 chr17:41440525 NA 0.59 8.41 0.42 1.23e-15 Menopause (age at onset); LUSC cis rs12681287 0.604 rs28378899 chr8:87434500 G/C cg27223183 chr8:87520930 FAM82B 0.54 7.47 0.38 6.96e-13 Caudate activity during reward; LUSC cis rs9325144 0.647 rs12231313 chr12:39101929 C/T cg13010199 chr12:38710504 ALG10B -0.52 -7.94 -0.4 3.03e-14 Morning vs. evening chronotype; LUSC cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg11657440 chr19:46296263 DMWD -0.52 -7.63 -0.39 2.49e-13 Coronary artery disease; LUSC cis rs7769051 0.522 rs34688576 chr6:133118214 C/T cg22852734 chr6:133119734 C6orf192 1.33 10.41 0.49 3.74e-22 Type 2 diabetes nephropathy; LUSC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg13770153 chr20:60521292 NA -0.44 -6.13 -0.32 2.43e-9 Body mass index; LUSC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs3740713 0.592 rs73434674 chr11:18411497 C/A cg23797887 chr11:18477753 LDHAL6A -0.47 -5.7 -0.3 2.65e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7223966 1.000 rs8075061 chr17:61804723 A/G cg00945038 chr17:61921165 SMARCD2 0.4 6.09 0.32 3.17e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9612 0.718 rs173202 chr19:44253588 C/T cg08581076 chr19:44259116 C19orf61 0.51 6.35 0.33 6.96e-10 Exhaled nitric oxide output; LUSC cis rs60733400 0.818 rs10909839 chr1:2708430 G/A cg18932078 chr1:2524107 MMEL1 0.3 6.43 0.33 4.33e-10 Multiple sclerosis; LUSC cis rs7605827 0.930 rs4140715 chr2:15515899 G/A cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.71e-17 Educational attainment (years of education); LUSC cis rs7605827 0.930 rs11687253 chr2:15655869 A/G cg19274914 chr2:15703543 NA -0.46 -8.63 -0.43 2.58e-16 Educational attainment (years of education); LUSC cis rs9309473 0.607 rs1522927 chr2:73556155 T/G cg20560298 chr2:73613845 ALMS1 -0.54 -8.3 -0.41 2.64e-15 Metabolite levels; LUSC trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg15704280 chr7:45808275 SEPT13 0.73 8.22 0.41 4.64e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs10108704 1.000 rs10108704 chr8:110362461 G/T cg20147595 chr8:110349212 ENY2 -0.44 -5.82 -0.3 1.41e-8 Multiple system atrophy (pathologically confirmed); LUSC cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg03676636 chr4:99064102 C4orf37 0.37 8.16 0.41 6.97e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9747201 0.926 rs35131420 chr17:80103631 T/C cg17462356 chr17:80056334 FASN 0.46 6.21 0.32 1.56e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10354764 chr16:3285464 ZNF200 0.42 6.23 0.32 1.37e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -5.99 -0.31 5.57e-9 Developmental language disorder (linguistic errors); LUSC cis rs9581857 0.615 rs79793528 chr13:28007823 G/A cg22138327 chr13:27999177 GTF3A 0.89 9.45 0.46 6.21e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC trans rs7939886 0.920 rs1552151 chr11:55780951 A/G cg15704280 chr7:45808275 SEPT13 -0.85 -7.46 -0.38 7.32e-13 Myopia (pathological); LUSC cis rs4363385 0.818 rs546666 chr1:153015385 A/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.89 -0.4 4.44e-14 Inflammatory skin disease; LUSC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg12560992 chr17:57184187 TRIM37 -0.9 -17.73 -0.7 4.75e-50 Intelligence (multi-trait analysis); LUSC cis rs2414856 0.510 rs72756979 chr15:64572551 G/A cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs501916 0.634 rs603569 chr15:48058929 G/A cg16110827 chr15:48056943 SEMA6D -0.38 -5.93 -0.31 7.5e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg19774624 chr17:42201019 HDAC5 -0.79 -12.66 -0.57 2.93e-30 Total body bone mineral density; LUSC cis rs763014 1.000 rs763014 chr16:675680 T/C cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.37e-10 Height; LUSC cis rs922692 0.744 rs12903203 chr15:79084933 T/C cg00540400 chr15:79124168 NA -0.4 -6.99 -0.36 1.54e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg16405210 chr4:1374714 KIAA1530 -0.6 -9.38 -0.46 1.08e-18 Longevity; LUSC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg05340658 chr4:99064831 C4orf37 0.58 9.66 0.47 1.25e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 0.850 rs28513374 chr15:44125495 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.93 0.44 2.83e-17 Lung cancer in ever smokers; LUSC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg20503657 chr10:835505 NA 0.99 14.15 0.61 6.33e-36 Eosinophil percentage of granulocytes; LUSC cis rs2798269 0.902 rs12861578 chr13:22092762 T/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.84 -0.3 1.25e-8 PR segment; LUSC cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg03146154 chr1:46216737 IPP 0.51 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9788682 1.000 rs12441354 chr15:78821016 G/A cg24631222 chr15:78858424 CHRNA5 0.81 11.05 0.52 2.19e-24 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg10802521 chr3:52805072 NEK4 -0.52 -8.52 -0.42 5.41e-16 Bipolar disorder; LUSC cis rs12534701 1.000 rs12534701 chr7:154680910 A/C cg24255201 chr7:154684926 DPP6 -0.37 -5.7 -0.3 2.6e-8 Colorectal cancer (diet interaction); LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.4e-14 Prudent dietary pattern; LUSC cis rs1775715 0.707 rs2808073 chr10:32179275 A/G cg03015672 chr10:32216066 ARHGAP12 0.32 5.79 0.3 1.61e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9457247 0.602 rs9457262 chr6:167473685 A/G cg25258033 chr6:167368657 RNASET2 0.45 6.81 0.35 4.5e-11 Crohn's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07431429 chr13:21750645 MRP63;SKA3 -0.58 -6.88 -0.35 3.01e-11 Bipolar disorder and schizophrenia; LUSC cis rs7914558 1.000 rs7077291 chr10:104945751 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.86 -0.35 3.32e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.25 0.52 4.06e-25 Colorectal cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18082014 chr19:46088293 OPA3 -0.46 -6.87 -0.35 3.17e-11 Electrocardiographic conduction measures; LUSC trans rs8072100 1.000 rs11870935 chr17:45732605 G/A cg04995722 chr7:26192034 NFE2L3 0.37 6.0 0.31 5.05e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg08704250 chr15:31115839 NA 0.58 9.13 0.45 6.46e-18 Huntington's disease progression; LUSC cis rs853679 0.556 rs45509595 chr6:27840926 T/C cg26958806 chr6:27640298 NA 0.79 5.96 0.31 6.38e-9 Depression; LUSC cis rs1997103 0.954 rs6953004 chr7:55411919 G/A cg17469321 chr7:55412551 NA 0.64 10.19 0.49 2.02e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg02951883 chr7:2050386 MAD1L1 -0.6 -11.19 -0.52 6.77e-25 Bipolar disorder and schizophrenia; LUSC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg00784671 chr22:46762841 CELSR1 -0.54 -6.79 -0.35 5.18e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg14004847 chr7:1930337 MAD1L1 -0.59 -9.14 -0.45 6.29e-18 Bipolar disorder and schizophrenia; LUSC cis rs262150 0.546 rs7798337 chr7:158801089 G/A cg09640425 chr7:158790006 NA 0.39 5.81 0.3 1.42e-8 Facial morphology (factor 20); LUSC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.51 -7.49 -0.38 6.15e-13 Axial length; LUSC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs7246967 0.551 rs75360744 chr19:22857956 G/T cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11890956 chr21:40555474 PSMG1 0.72 11.09 0.52 1.56e-24 Menarche (age at onset); LUSC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg15145296 chr3:125709740 NA -0.57 -6.36 -0.33 6.67e-10 Blood pressure (smoking interaction); LUSC cis rs1371867 0.846 rs1788194 chr8:101277916 T/C cg06636551 chr8:101224915 SPAG1 -0.43 -7.92 -0.4 3.51e-14 Atrioventricular conduction; LUSC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg16928487 chr17:17741425 SREBF1 -0.35 -6.84 -0.35 3.81e-11 Total body bone mineral density; LUSC cis rs2242116 0.592 rs6442039 chr3:46960797 C/G cg16586182 chr3:47516702 SCAP -0.5 -6.05 -0.31 3.83e-9 Birth weight; LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.71 0.34 8.28e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg22875332 chr1:76189707 ACADM 0.66 9.12 0.45 7.39e-18 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10761482 0.500 rs1938535 chr10:62273900 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.44 -0.33 4.08e-10 Schizophrenia; LUSC cis rs9399135 0.967 rs6929661 chr6:135328792 G/A cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Red blood cell count; LUSC cis rs11958404 0.932 rs6865373 chr5:157436728 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7264396 0.563 rs6058312 chr20:34324484 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.38 -0.42 1.49e-15 Total cholesterol levels; LUSC cis rs79387448 0.745 rs72993722 chr2:103124916 A/G cg09003973 chr2:102972529 NA 0.86 8.52 0.42 5.6e-16 Gut microbiota (bacterial taxa); LUSC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg18681998 chr4:17616180 MED28 0.85 15.84 0.65 1.54e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.91 0.35 2.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs950027 0.620 rs1617984 chr15:45622662 A/G cg26924012 chr15:45694286 SPATA5L1 0.8 12.4 0.56 2.61e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg14004847 chr7:1930337 MAD1L1 -0.5 -7.63 -0.39 2.44e-13 Bipolar disorder and schizophrenia; LUSC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg01416388 chr22:39784598 NA -0.45 -6.94 -0.36 2.02e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs853679 0.546 rs35744819 chr6:28318331 G/T cg06606381 chr12:133084897 FBRSL1 -1.09 -9.57 -0.46 2.43e-19 Depression; LUSC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.54 0.34 2.24e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs11585357 0.895 rs2501795 chr1:17633499 A/G cg08277548 chr1:17600880 PADI3 -0.66 -7.24 -0.37 3.15e-12 Hair shape; LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs6541297 0.941 rs6690424 chr1:230278892 C/T cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.22e-15 Coronary artery disease; LUSC cis rs9399135 0.967 rs6915770 chr6:135369214 G/A cg22676075 chr6:135203613 NA 0.46 7.13 0.36 6.1e-12 Red blood cell count; LUSC cis rs10779751 0.770 rs2015818 chr1:11170743 G/A cg08854313 chr1:11322531 MTOR 0.82 13.5 0.59 1.92e-33 Body mass index; LUSC cis rs6693567 0.545 rs6699093 chr1:150440451 A/G cg15654264 chr1:150340011 RPRD2 -0.46 -7.46 -0.38 7.73e-13 Migraine; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.735 rs2280306 chr15:76652258 C/G cg23625390 chr15:77176239 SCAPER -0.61 -9.69 -0.47 9.85e-20 Blood metabolite levels; LUSC cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg14844989 chr11:31128820 NA -0.37 -5.71 -0.3 2.49e-8 Red blood cell count; LUSC cis rs7296418 0.961 rs1790122 chr12:123606739 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.89 -0.35 2.7e-11 Platelet count; LUSC trans rs3857536 0.740 rs6455080 chr6:66887413 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.22 -0.32 1.47e-9 Blood trace element (Cu levels); LUSC cis rs1198872 0.526 rs57282335 chr2:10928207 G/A cg15705551 chr2:10952987 PDIA6 0.52 6.51 0.34 2.71e-10 Cardiac Troponin-T levels; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg22667436 chr7:134671749 AGBL3 0.43 6.65 0.34 1.2e-10 Schizophrenia; LUSC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg06740227 chr12:86229804 RASSF9 0.45 7.15 0.36 5.35e-12 Major depressive disorder; LUSC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg20203395 chr5:56204925 C5orf35 0.77 10.38 0.49 4.54e-22 Initial pursuit acceleration; LUSC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg26380479 chr7:97908229 NA -0.26 -5.86 -0.31 1.13e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03576123 chr11:487126 PTDSS2 -0.95 -10.15 -0.49 2.75e-21 Body mass index; LUSC cis rs10876993 0.928 rs10082911 chr12:58104104 C/A cg18357645 chr12:58087776 OS9 0.6 9.02 0.44 1.51e-17 Celiac disease or Rheumatoid arthritis; LUSC cis rs4363385 0.693 rs581447 chr1:153033269 A/G cg00922841 chr1:152955080 SPRR1A -0.42 -7.28 -0.37 2.39e-12 Inflammatory skin disease; LUSC cis rs9788682 0.747 rs2568485 chr15:78752114 C/T cg18825076 chr15:78729989 IREB2 -0.47 -6.61 -0.34 1.48e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg01475377 chr6:109611718 NA -0.38 -6.75 -0.35 6.74e-11 Reticulocyte fraction of red cells; LUSC cis rs2200578 0.732 rs56143125 chr2:99565143 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.5 5.82 0.3 1.42e-8 IgG glycosylation; LUSC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg04315214 chr1:2043799 PRKCZ -0.4 -8.04 -0.4 1.6e-14 Height; LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.18 -0.32 1.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg16928487 chr17:17741425 SREBF1 0.37 7.11 0.36 7.28e-12 Total body bone mineral density; LUSC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg05425664 chr17:57184151 TRIM37 -0.56 -8.39 -0.42 1.38e-15 Intelligence (multi-trait analysis); LUSC cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.47 -5.7 -0.3 2.67e-8 Birth weight; LUSC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg11494091 chr17:61959527 GH2 0.38 6.5 0.34 2.86e-10 Height; LUSC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.51 0.34 2.78e-10 Lung cancer; LUSC cis rs208520 0.770 rs1342960 chr6:66883514 T/C cg07460842 chr6:66804631 NA -1.06 -15.7 -0.65 5.45e-42 Exhaled nitric oxide output; LUSC trans rs7181230 0.885 rs4497657 chr15:40359433 A/T cg22705835 chr10:65332833 REEP3 -0.39 -6.34 -0.33 7.41e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg17554472 chr22:41940697 POLR3H -0.48 -5.94 -0.31 7.16e-9 Vitiligo; LUSC trans rs877282 1.000 rs71491304 chr10:772982 C/T cg22713356 chr15:30763199 NA 1.08 15.38 0.64 9.93e-41 Uric acid levels; LUSC cis rs10208940 0.920 rs6724540 chr2:68779356 A/G cg12452813 chr2:68675892 NA 0.57 5.84 0.3 1.23e-8 Urate levels in lean individuals; LUSC cis rs3849570 0.925 rs9841087 chr3:81907949 A/G cg07356753 chr3:81810745 GBE1 -0.7 -11.56 -0.53 3.25e-26 Waist circumference;Body mass index; LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.34 0.59 7.64e-33 Platelet count; LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg05165339 chr4:1420672 NA 0.3 7.1 0.36 7.69e-12 Longevity; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg13453750 chr1:205783389 SLC41A1 -0.3 -5.9 -0.31 8.7e-9 Menarche (age at onset); LUSC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg09165964 chr15:75287851 SCAMP5 0.46 6.82 0.35 4.23e-11 Breast cancer; LUSC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg14552801 chr7:65878734 NA -0.46 -6.54 -0.34 2.31e-10 Aortic root size; LUSC cis rs7582720 1.000 rs72932553 chr2:203842661 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.68 0.47 1.04e-19 Personality dimensions; LUSC cis rs2439831 0.571 rs2470121 chr15:43937618 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg27532560 chr4:187881888 NA 0.36 5.88 0.31 9.76e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg26441486 chr22:50317300 CRELD2 -0.49 -7.46 -0.38 7.33e-13 Schizophrenia; LUSC trans rs7819412 0.505 rs17726209 chr8:11022185 C/T cg06636001 chr8:8085503 FLJ10661 0.49 6.89 0.35 2.77e-11 Triglycerides; LUSC cis rs7903847 0.642 rs2275089 chr10:99141205 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.28 -0.37 2.45e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7937682 0.883 rs1611989 chr11:111456299 A/G cg09085632 chr11:111637200 PPP2R1B -1.01 -15.59 -0.65 1.42e-41 Primary sclerosing cholangitis; LUSC cis rs2692947 0.770 rs12471925 chr2:96555522 C/A cg22654517 chr2:96458247 NA 0.37 6.9 0.35 2.68e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs7681440 0.583 rs2737019 chr4:90744903 G/T cg06632027 chr4:90757378 SNCA -0.36 -5.72 -0.3 2.43e-8 Dementia with Lewy bodies; LUSC trans rs11098499 0.954 rs10518328 chr4:120401779 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 4.01e-10 Corneal astigmatism; LUSC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg21775007 chr8:11205619 TDH -0.45 -6.72 -0.35 7.75e-11 Neuroticism; LUSC cis rs2976388 1.000 rs1045547 chr8:143763757 T/G cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13126279 chr21:47581558 C21orf56 -0.54 -8.02 -0.4 1.85e-14 Testicular germ cell tumor; LUSC cis rs113835537 0.529 rs17495838 chr11:66196265 T/C cg24851651 chr11:66362959 CCS 0.54 7.57 0.38 3.59e-13 Airway imaging phenotypes; LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg22764044 chr5:178986830 RUFY1 0.53 9.04 0.44 1.27e-17 Lung cancer; LUSC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg14061069 chr19:46274453 DMPK 0.69 14.13 0.61 7.6e-36 Coronary artery disease; LUSC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg26061582 chr7:22766209 IL6 0.49 7.02 0.36 1.25e-11 Lung cancer; LUSC cis rs11155671 0.530 rs9383914 chr6:150207234 T/G cg09699651 chr6:150184138 LRP11 0.45 7.15 0.36 5.64e-12 Testicular germ cell tumor; LUSC cis rs1215050 0.791 rs592053 chr4:98732220 C/T cg05340658 chr4:99064831 C4orf37 0.44 6.85 0.35 3.47e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg06108461 chr20:60628389 TAF4 -1.01 -17.41 -0.69 9.34e-49 Body mass index; LUSC cis rs748404 0.578 rs510108 chr15:43605439 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.48 6.71 0.34 8.4e-11 Lung cancer; LUSC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11890956 chr21:40555474 PSMG1 -0.75 -11.63 -0.54 1.7e-26 Menarche (age at onset); LUSC cis rs7586879 1.000 rs7586879 chr2:25116977 C/T cg04586622 chr2:25135609 ADCY3 0.31 6.01 0.31 4.95e-9 Body mass index; LUSC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg05425664 chr17:57184151 TRIM37 0.59 9.16 0.45 5.54e-18 Intelligence (multi-trait analysis); LUSC cis rs4925386 0.681 rs2427296 chr20:60927475 G/A cg03359095 chr20:61002866 C20orf151 -0.28 -5.68 -0.3 2.93e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs4356932 1.000 rs6814817 chr4:76951170 C/T cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.59e-8 Blood protein levels; LUSC cis rs2050392 0.861 rs303448 chr10:30727084 G/T cg18806716 chr10:30721971 MAP3K8 -0.48 -8.01 -0.4 1.98e-14 Inflammatory bowel disease; LUSC cis rs5769707 0.935 rs9616332 chr22:50047678 C/G cg08680598 chr22:49984980 NA -0.34 -6.31 -0.33 8.88e-10 Monocyte count;Monocyte percentage of white cells; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19168507 chr11:107436485 ALKBH8 -0.4 -5.95 -0.31 6.89e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7107174 1.000 rs7111986 chr11:78102266 G/T cg02023728 chr11:77925099 USP35 0.46 6.7 0.34 9.09e-11 Testicular germ cell tumor; LUSC cis rs13082711 0.640 rs66941564 chr3:27259702 C/A cg02860705 chr3:27208620 NA 0.67 11.81 0.54 3.78e-27 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs910316 0.737 rs91144 chr14:75449517 G/A cg11812906 chr14:75593930 NEK9 -0.65 -10.66 -0.5 5.04e-23 Height; LUSC cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -8.87 -0.44 4.46e-17 Monocyte percentage of white cells; LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg09704166 chr2:114031854 PAX8;LOC440839 0.45 7.6 0.38 2.96e-13 Lymphocyte counts; LUSC cis rs7769051 0.808 rs1467404 chr6:133090141 A/G cg22852734 chr6:133119734 C6orf192 -1.1 -13.67 -0.6 4.13e-34 Type 2 diabetes nephropathy; LUSC cis rs9921338 0.961 rs72773834 chr16:11413293 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.75 -0.35 6.64e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs227833 1.000 rs227832 chr6:44681257 T/C cg20913747 chr6:44695427 NA 0.37 5.75 0.3 2e-8 Monobrow; LUSC cis rs11785400 0.731 rs4736363 chr8:143742112 C/A cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs7819412 0.668 rs2409715 chr8:11010136 A/T cg15556689 chr8:8085844 FLJ10661 -0.47 -6.58 -0.34 1.82e-10 Triglycerides; LUSC cis rs3744061 0.557 rs4261576 chr17:74648486 G/T cg27546012 chr17:74684504 MXRA7 0.37 6.6 0.34 1.66e-10 Retinal arteriolar caliber; LUSC cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg15073853 chr19:18549131 ISYNA1 -0.32 -5.84 -0.3 1.24e-8 Breast cancer; LUSC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg17971929 chr21:40555470 PSMG1 0.75 12.25 0.56 9.28e-29 Cognitive function; LUSC trans rs445114 0.509 rs386883 chr8:128336871 G/A cg10195415 chr17:73887371 TRIM65 0.42 6.66 0.34 1.11e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg06634786 chr22:41940651 POLR3H 0.53 6.3 0.33 9.27e-10 Vitiligo; LUSC cis rs4072705 0.617 rs10283445 chr9:127243637 A/G cg13476313 chr9:127244764 NR5A1 0.35 6.91 0.35 2.49e-11 Menarche (age at onset); LUSC trans rs2840044 0.534 rs167691 chr17:33885826 G/A cg19694781 chr19:47549865 TMEM160 -0.42 -6.76 -0.35 6.06e-11 Response to radiotherapy in cancer (late toxicity); LUSC trans rs10802346 0.545 rs1361408 chr1:246410054 T/G cg13514129 chr1:39547527 MACF1 0.74 11.87 0.54 2.39e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7824557 0.527 rs2736298 chr8:11235136 C/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.92 -0.31 7.82e-9 Retinal vascular caliber; LUSC cis rs2115536 0.967 rs3826008 chr15:80189805 G/T cg00225070 chr15:80189496 MTHFS 0.62 9.62 0.47 1.64e-19 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg00310523 chr12:86230176 RASSF9 0.51 9.68 0.47 1.07e-19 Major depressive disorder; LUSC cis rs13082711 0.863 rs77135084 chr3:27423549 A/C cg02860705 chr3:27208620 NA 0.5 8.64 0.43 2.34e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7954584 1.000 rs7954584 chr12:122461566 G/A cg21016266 chr12:122356598 WDR66 0.42 6.04 0.31 4.17e-9 Mean corpuscular volume; LUSC cis rs6087771 0.747 rs6058261 chr20:30235470 C/A cg18721089 chr20:30220636 NA -0.33 -5.81 -0.3 1.44e-8 Subcortical brain region volumes;Putamen volume; LUSC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs6076065 0.748 rs2281431 chr20:23399304 C/G cg11657817 chr20:23433608 CST11 0.53 10.82 0.51 1.42e-23 Facial morphology (factor 15, philtrum width); LUSC cis rs1865721 0.771 rs4410169 chr18:73138840 A/G cg26385618 chr18:73139727 C18orf62 -0.55 -10.11 -0.48 3.98e-21 Intelligence; LUSC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg22508957 chr16:3507546 NAT15 -0.4 -6.25 -0.32 1.26e-9 Body mass index (adult); LUSC cis rs478304 0.593 rs7120713 chr11:65483374 G/C cg27068330 chr11:65405492 SIPA1 -0.75 -10.35 -0.49 5.91e-22 Acne (severe); LUSC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs2637266 1.000 rs2395385 chr10:78341125 G/A cg18941641 chr10:78392320 NA 0.4 7.41 0.38 1.04e-12 Pulmonary function; LUSC cis rs7712401 0.601 rs30058 chr5:122297703 A/G cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg12257692 chr3:49977190 RBM6 -0.25 -6.98 -0.36 1.61e-11 Body mass index; LUSC cis rs7072216 0.691 rs3829853 chr10:100171174 A/G cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg01416388 chr22:39784598 NA -0.42 -6.94 -0.35 2.11e-11 Intelligence (multi-trait analysis); LUSC cis rs8099014 0.954 rs4559989 chr18:56131869 G/A cg12907477 chr18:56117327 MIR122 0.42 6.4 0.33 5.34e-10 Platelet count; LUSC cis rs9467773 1.000 rs6456733 chr6:26566804 C/T cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.545 rs2378335 chr20:33756830 A/C cg08999081 chr20:33150536 PIGU 0.35 5.88 0.31 1.02e-8 Height; LUSC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg24209194 chr3:40518798 ZNF619 0.48 6.43 0.33 4.3e-10 Renal cell carcinoma; LUSC cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg26384229 chr12:38710491 ALG10B 0.84 13.92 0.61 4.87e-35 Bladder cancer; LUSC cis rs2692947 0.683 rs2315416 chr2:96558477 C/T cg23100626 chr2:96804247 ASTL 0.26 6.36 0.33 6.62e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2354432 0.556 rs7525622 chr1:146774116 G/A cg25205988 chr1:146714368 CHD1L -1.03 -9.57 -0.46 2.48e-19 Mitochondrial DNA levels; LUSC cis rs7089973 0.604 rs1359079 chr10:116582502 A/G cg03647239 chr10:116582469 FAM160B1 0.45 7.21 0.37 3.81e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg27279351 chr12:120934652 DYNLL1 0.66 8.79 0.43 8.12e-17 High light scatter reticulocyte count; LUSC cis rs4290604 0.748 rs10164697 chr2:238032560 G/A cg23555395 chr2:238036564 NA -0.52 -6.79 -0.35 5.08e-11 Asthma; LUSC cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg12219531 chr12:120966889 COQ5 0.6 8.08 0.4 1.2e-14 High light scatter reticulocyte count; LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03934478 chr11:495069 RNH1 0.82 9.89 0.48 2.07e-20 Body mass index; LUSC cis rs17095355 0.605 rs41291880 chr10:111635785 A/G cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.63 -0.34 1.3100000000000001e-10 Biliary atresia; LUSC cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg13256891 chr4:100009986 ADH5 0.51 6.89 0.35 2.74e-11 Alcohol dependence; LUSC cis rs9653442 0.593 rs7597861 chr2:100853187 G/A cg22139774 chr2:100720529 AFF3 -0.39 -6.4 -0.33 5.38e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg18252515 chr7:66147081 NA -1.19 -13.37 -0.59 5.95e-33 Diabetic kidney disease; LUSC cis rs12928939 0.517 rs12149307 chr16:71968091 A/C cg03805757 chr16:71968109 PKD1L3 -0.64 -9.8 -0.47 4.31e-20 Post bronchodilator FEV1; LUSC cis rs34779708 0.931 rs4007289 chr10:35269790 G/A cg04310649 chr10:35416472 CREM -0.39 -5.98 -0.31 5.78e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2602836 0.830 rs2602874 chr4:100039396 A/T cg13256891 chr4:100009986 ADH5 0.52 8.47 0.42 7.94e-16 HDL cholesterol;HDL cholesterol levels; LUSC cis rs977987 0.778 rs7203157 chr16:75417920 T/C cg03315344 chr16:75512273 CHST6 0.48 9.1 0.45 8.27e-18 Dupuytren's disease; LUSC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.57 0.38 3.63e-13 Multiple sclerosis; LUSC cis rs10876993 0.893 rs3825078 chr12:58089413 A/T cg15848620 chr12:58087721 OS9 -0.57 -8.08 -0.4 1.18e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs6681460 0.834 rs1280310 chr1:67216823 T/A cg02459107 chr1:67143332 SGIP1 -0.47 -8.35 -0.42 1.81e-15 Presence of antiphospholipid antibodies; LUSC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg02117656 chr17:79614917 TSPAN10 0.32 5.86 0.31 1.1e-8 Eye color traits; LUSC cis rs568617 1.000 rs656980 chr11:65656282 G/A cg19792802 chr11:65647270 CTSW 0.4 6.24 0.32 1.35e-9 Crohn's disease; LUSC cis rs9807841 0.592 rs2043304 chr19:10772112 T/C cg17710535 chr19:10819994 QTRT1 0.42 6.88 0.35 2.98e-11 Inflammatory skin disease; LUSC trans rs7989336 0.501 rs7985691 chr13:97007163 G/C cg03198741 chr6:1003969 LOC285768 -0.4 -6.07 -0.32 3.52e-9 Obesity; LUSC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg01579765 chr21:45077557 HSF2BP -0.52 -10.87 -0.51 9.44e-24 Mean corpuscular volume; LUSC cis rs9399135 0.967 rs17638970 chr6:135320063 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Red blood cell count; LUSC cis rs10754283 0.967 rs6428561 chr1:90102619 G/A cg21401794 chr1:90099060 LRRC8C 0.65 9.79 0.47 4.51e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 18.1 0.7 1.66e-51 Chronic sinus infection; LUSC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg19266014 chr7:2183958 MAD1L1 -0.33 -5.65 -0.3 3.41e-8 Schizophrenia; LUSC cis rs7954584 0.813 rs1523261 chr12:122462877 C/A cg21016266 chr12:122356598 WDR66 0.44 6.26 0.32 1.16e-9 Mean corpuscular volume; LUSC trans rs877282 0.853 rs7083589 chr10:754494 G/A cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.02 -0.4 1.79e-14 Type 2 diabetes; LUSC cis rs681343 1.000 rs516316 chr19:49206145 C/G cg21064579 chr19:49206444 FUT2 0.44 8.56 0.42 4.11e-16 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; LUSC cis rs79976124 0.800 rs6918860 chr6:66637741 G/C cg07460842 chr6:66804631 NA 0.7 8.69 0.43 1.68e-16 Type 2 diabetes; LUSC trans rs9556711 0.581 rs16954076 chr13:98054592 G/T cg03186877 chr9:34628238 ARID3C 0.6 6.2 0.32 1.66e-9 Alcoholism (alcohol use disorder factor score);Alcoholism (alcohol dependence factor score); LUSC cis rs4555082 1.000 rs4334224 chr14:105759198 C/T cg06808227 chr14:105710500 BRF1 -0.63 -9.69 -0.47 9.62e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs9393777 0.588 rs9467772 chr6:26496578 A/T cg12826209 chr6:26865740 GUSBL1 0.69 7.99 0.4 2.14e-14 Intelligence (multi-trait analysis); LUSC cis rs367943 1.000 rs348957 chr5:112821178 C/T cg12552261 chr5:112820674 MCC 0.44 7.11 0.36 7.19e-12 Type 2 diabetes; LUSC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg05941027 chr17:61774174 LIMD2 0.22 5.69 0.3 2.84e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9039 1.000 rs11075212 chr16:9203899 G/A cg08831531 chr16:9218945 NA -0.67 -10.04 -0.48 6.5e-21 Menopause (age at onset); LUSC trans rs4714291 0.963 rs2395543 chr6:39965020 A/G cg02267698 chr19:7991119 CTXN1 0.52 7.39 0.37 1.21e-12 Strep throat; LUSC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg14895029 chr7:2775587 GNA12 0.36 5.75 0.3 2.05e-8 Height; LUSC trans rs4295623 0.585 rs13259242 chr8:11593033 T/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.3 -0.33 9.14e-10 Morning vs. evening chronotype; LUSC cis rs3020736 0.500 rs8143153 chr22:42515637 G/C cg15557168 chr22:42548783 NA 0.48 7.39 0.38 1.16e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs9326248 0.559 rs4938334 chr11:116931042 G/C cg26566898 chr11:117069891 TAGLN 0.35 6.69 0.34 9.68e-11 Blood protein levels; LUSC cis rs6967385 0.560 rs12673036 chr7:12343463 A/G cg20607287 chr7:12443886 VWDE 0.47 7.12 0.36 6.53e-12 Response to taxane treatment (placlitaxel); LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg11843238 chr5:131593191 PDLIM4 0.37 6.3 0.33 9.45e-10 Breast cancer; LUSC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12667521 chr19:29218732 NA 0.63 9.05 0.44 1.18e-17 Methadone dose in opioid dependence; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg13470557 chr20:61431876 C20orf20 -0.4 -6.48 -0.33 3.24e-10 N-glycan levels; LUSC cis rs13256369 0.802 rs12153 chr8:8560909 G/C cg06671706 chr8:8559999 CLDN23 0.5 6.55 0.34 2.21e-10 Obesity-related traits; LUSC cis rs7959452 0.640 rs4761233 chr12:69722880 T/C cg11871910 chr12:69753446 YEATS4 0.67 10.27 0.49 1.12e-21 Blood protein levels; LUSC cis rs6681460 1.000 rs4655636 chr1:67068537 A/G cg02459107 chr1:67143332 SGIP1 0.48 8.93 0.44 2.91e-17 Presence of antiphospholipid antibodies; LUSC cis rs7760535 0.826 rs10872068 chr6:111849860 C/G cg22127309 chr6:111907043 TRAF3IP2 0.39 7.49 0.38 6.1e-13 Metabolic traits; LUSC cis rs9443645 0.527 rs10943608 chr6:79674929 T/C cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.92 -0.31 7.92e-9 Intelligence (multi-trait analysis); LUSC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 12.03 0.55 6.37e-28 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg18876405 chr7:65276391 NA 0.55 8.8 0.43 7.72e-17 Aortic root size; LUSC cis rs12620999 0.941 rs10803654 chr2:238036570 C/T cg23555395 chr2:238036564 NA -0.53 -8.94 -0.44 2.77e-17 Systemic lupus erythematosus; LUSC cis rs12541635 0.966 rs12681183 chr8:107007156 T/A cg10147462 chr8:107024639 NA 0.55 9.97 0.48 1.16e-20 Age of smoking initiation; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg19318889 chr4:1322082 MAEA 0.43 6.98 0.36 1.58e-11 Obesity-related traits; LUSC cis rs11758351 1.000 rs16891401 chr6:26202337 G/A cg23601095 chr6:26197514 HIST1H3D 0.73 7.47 0.38 7.08e-13 Gout;Renal underexcretion gout; LUSC cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.83 -0.54 3.41e-27 Chronic sinus infection; LUSC cis rs7106204 0.609 rs11824883 chr11:24284952 G/A ch.11.24196551F chr11:24239977 NA 0.72 6.05 0.31 3.93e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9457247 0.967 rs428805 chr6:167403132 C/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs2439831 0.867 rs28461955 chr15:43661459 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 4.03e-19 Lung cancer in ever smokers; LUSC cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.43 -0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg05084668 chr3:125655381 ALG1L -0.48 -6.87 -0.35 3.17e-11 Blood pressure (smoking interaction); LUSC cis rs11122272 0.525 rs2749713 chr1:231537921 T/C cg06096015 chr1:231504339 EGLN1 0.54 9.51 0.46 3.95e-19 Hemoglobin concentration; LUSC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs72634258 0.554 rs12723500 chr1:7857374 G/C cg26816564 chr1:7831052 VAMP3 0.98 13.2 0.59 2.63e-32 Inflammatory bowel disease; LUSC cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.34 5.66 0.3 3.29e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1728785 0.818 rs11075684 chr16:68582365 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.86 -0.31 1.11e-8 Ulcerative colitis; LUSC cis rs9325144 0.624 rs7309400 chr12:39150369 G/C cg26384229 chr12:38710491 ALG10B -0.6 -9.28 -0.45 2.15e-18 Morning vs. evening chronotype; LUSC cis rs8017423 0.967 rs4904657 chr14:90721600 A/G cg04374321 chr14:90722782 PSMC1 0.75 12.12 0.55 2.92e-28 Mortality in heart failure; LUSC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.49 8.73 0.43 1.28e-16 Total body bone mineral density; LUSC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg22875332 chr1:76189707 ACADM -0.84 -14.4 -0.62 6.39e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4595586 0.545 rs12814188 chr12:39380853 C/T cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg02711726 chr17:80685570 FN3KRP -0.42 -6.3 -0.33 9.48e-10 Glycated hemoglobin levels; LUSC trans rs11700980 0.551 rs56000932 chr21:30116268 G/A cg14791747 chr16:20752902 THUMPD1 0.55 5.98 0.31 5.63e-9 QRS complex (12-leadsum); LUSC cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg26384229 chr12:38710491 ALG10B 0.84 13.62 0.6 6.77e-34 Bladder cancer; LUSC cis rs2860975 0.936 rs1934973 chr10:96783601 A/C cg09036531 chr10:96991505 NA -0.41 -5.75 -0.3 2.06e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC trans rs6502050 0.835 rs35555954 chr17:80122438 T/C cg07393940 chr7:158741817 NA 0.36 6.55 0.34 2.16e-10 Life satisfaction; LUSC cis rs2190422 0.577 rs6465922 chr7:103094968 A/G cg04218035 chr7:103086829 SLC26A5 0.3 5.89 0.31 9.51e-9 Morning vs. evening chronotype; LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg11843238 chr5:131593191 PDLIM4 0.51 9.04 0.44 1.32e-17 Acylcarnitine levels; LUSC cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.12 -0.45 7.37e-18 Schizophrenia; LUSC cis rs1808579 0.935 rs1805082 chr18:21120444 C/T cg14672496 chr18:21087552 C18orf8 -0.34 -5.95 -0.31 6.91e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs4343996 0.530 rs10262783 chr7:3431165 T/C cg21248987 chr7:3385318 SDK1 0.36 6.01 0.31 4.82e-9 Motion sickness; LUSC cis rs8114671 0.967 rs6142324 chr20:33789043 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -5.92 -0.31 7.84e-9 Height; LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.24e-12 Platelet count; LUSC cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg10978503 chr1:24200527 CNR2 -0.45 -9.38 -0.46 1.03e-18 Immature fraction of reticulocytes; LUSC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg03929089 chr4:120376271 NA -0.96 -15.5 -0.65 3.22e-41 Coronary artery disease; LUSC cis rs11105298 0.891 rs12369685 chr12:89928905 A/G cg00757033 chr12:89920650 WDR51B 0.58 9.87 0.48 2.47e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg08975724 chr8:8085496 FLJ10661 0.39 5.72 0.3 2.39e-8 Mood instability; LUSC cis rs7582180 0.629 rs13004216 chr2:100945402 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.82 -0.3 1.42e-8 Platelet count; LUSC cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg24503407 chr1:205819492 PM20D1 0.9 16.95 0.68 6.11e-47 Menarche (age at onset); LUSC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg23711669 chr6:146136114 FBXO30 0.88 15.95 0.66 5.59e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg18827107 chr12:86230957 RASSF9 0.44 6.77 0.35 5.96e-11 Major depressive disorder; LUSC cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs9653442 0.527 rs4851258 chr2:100780830 T/C cg07810366 chr2:100720526 AFF3 -0.44 -7.49 -0.38 6.12e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11622475 0.651 rs34982025 chr14:104360431 G/A cg12183467 chr14:104352244 NA -0.5 -9.87 -0.48 2.56e-20 Bipolar disorder; LUSC cis rs62027291 1.000 rs5021805 chr15:77290300 G/A cg26408565 chr15:76604113 ETFA 0.55 6.7 0.34 8.9e-11 Plateletcrit; LUSC cis rs4478858 0.654 rs113490486 chr1:31712863 C/G cg00250761 chr1:31883323 NA -0.34 -8.21 -0.41 4.93e-15 Alcohol dependence; LUSC cis rs826838 1.000 rs826851 chr12:39112639 A/G cg26384229 chr12:38710491 ALG10B -0.83 -15.46 -0.65 4.66e-41 Heart rate; LUSC cis rs79911532 0.515 rs17148983 chr7:75649821 C/G cg03592824 chr7:75666768 STYXL1 0.71 6.92 0.35 2.26e-11 Mononucleosis; LUSC cis rs73206853 0.841 rs4131852 chr12:110812657 C/G cg12870014 chr12:110450643 ANKRD13A 0.67 6.63 0.34 1.32e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg25767906 chr1:53392781 SCP2 0.47 8.41 0.42 1.22e-15 Monocyte count; LUSC cis rs2204008 0.540 rs1283306 chr12:38153778 C/A cg26384229 chr12:38710491 ALG10B -0.66 -10.26 -0.49 1.18e-21 Bladder cancer; LUSC trans rs800082 0.966 rs2575192 chr3:144281170 C/T cg24215973 chr2:240111563 HDAC4 0.47 7.05 0.36 1.03e-11 Smoking behavior; LUSC cis rs2274273 0.870 rs4366639 chr14:55790516 T/G cg04306507 chr14:55594613 LGALS3 0.54 11.81 0.54 3.98e-27 Protein biomarker; LUSC cis rs35000415 0.873 rs34748780 chr7:128700153 A/G cg19972273 chr7:128594194 NA 0.63 5.72 0.3 2.34e-8 Systemic lupus erythematosus; LUSC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg16545954 chr1:2118288 C1orf86 0.36 6.98 0.36 1.61e-11 Height; LUSC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.8 -0.39 7.89e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg17644776 chr2:200775616 C2orf69 -0.44 -6.56 -0.34 2.09e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs3740713 1.000 rs16935432 chr11:18470487 G/A cg23797887 chr11:18477753 LDHAL6A -0.56 -6.77 -0.35 5.8e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg04518342 chr5:131593106 PDLIM4 0.41 7.48 0.38 6.53e-13 Breast cancer; LUSC cis rs11209002 0.876 rs7517744 chr1:67570879 T/C cg02640540 chr1:67518911 SLC35D1 0.68 7.78 0.39 8.99e-14 Crohn's disease; LUSC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg26380479 chr7:97908229 NA -0.27 -6.13 -0.32 2.54e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7769051 0.522 rs6911773 chr6:133128848 T/C cg22852734 chr6:133119734 C6orf192 1.33 10.3 0.49 8.52e-22 Type 2 diabetes nephropathy; LUSC cis rs909341 0.808 rs2263805 chr20:62351150 T/C cg09650180 chr20:62225654 GMEB2 -0.47 -6.11 -0.32 2.75e-9 Atopic dermatitis; LUSC cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg06547715 chr2:218990976 CXCR2 0.33 6.47 0.33 3.57e-10 Ulcerative colitis; LUSC cis rs8114671 0.836 rs2425006 chr20:33571228 T/G cg07148914 chr20:33460835 GGT7 -0.44 -6.47 -0.33 3.41e-10 Height; LUSC cis rs75557865 1 rs75557865 chr3:121652141 G/A cg20356878 chr3:121714668 ILDR1 0.68 12.0 0.55 7.97e-28 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1577917 0.958 rs12213331 chr6:86504797 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -6.92 -0.35 2.34e-11 Response to antipsychotic treatment; LUSC cis rs9322817 0.691 rs17680345 chr6:105337409 A/T cg02098413 chr6:105308735 HACE1 0.28 5.96 0.31 6.53e-9 Thyroid stimulating hormone; LUSC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg21984481 chr17:79567631 NPLOC4 0.67 13.88 0.6 6.79e-35 Eye color traits; LUSC cis rs7223966 1.000 rs8081612 chr17:61724695 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.53 -7.54 -0.38 4.47e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg14983838 chr19:29218262 NA -0.52 -6.04 -0.31 4.2e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg02423579 chr7:2872169 GNA12 -0.44 -6.63 -0.34 1.37e-10 Height; LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.44 0.46 6.63e-19 Bipolar disorder; LUSC trans rs34421088 0.532 rs2736385 chr8:11148613 T/C cg15556689 chr8:8085844 FLJ10661 0.45 6.67 0.34 1.08e-10 Neuroticism; LUSC cis rs2486288 0.656 rs1060896 chr15:45554267 C/A cg09092052 chr15:45571596 NA 0.45 6.26 0.32 1.18e-9 Glomerular filtration rate; LUSC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg22963979 chr7:1858916 MAD1L1 0.55 8.62 0.43 2.8e-16 Bipolar disorder and schizophrenia; LUSC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg11812906 chr14:75593930 NEK9 0.63 10.55 0.5 1.22e-22 Height; LUSC trans rs3942852 0.868 rs7118232 chr11:48106274 T/C cg15704280 chr7:45808275 SEPT13 -0.53 -6.19 -0.32 1.71e-9 Acute lymphoblastic leukemia (childhood); LUSC trans rs1493916 0.837 rs9952002 chr18:31414314 C/G cg27147174 chr7:100797783 AP1S1 -0.57 -8.89 -0.44 3.89e-17 Life satisfaction; LUSC cis rs969413 0.624 rs9914093 chr17:79260653 C/G cg25342872 chr17:79175132 AZI1 -0.38 -6.18 -0.32 1.82e-9 Frontotemporal dementia; LUSC cis rs9517320 0.534 rs9556962 chr13:99156648 C/T cg20487152 chr13:99095054 FARP1 -0.44 -7.75 -0.39 1.11e-13 Longevity; LUSC cis rs9399135 0.967 rs12527707 chr6:135324511 G/A cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Red blood cell count; LUSC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg21361702 chr7:150065534 REPIN1 0.5 6.46 0.33 3.72e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7223966 0.921 rs2727300 chr17:61965398 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.84 0.35 3.9e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs921665 0.680 rs7571242 chr2:3199025 A/G cg16434511 chr2:3151078 NA -0.63 -6.62 -0.34 1.41e-10 World class endurance athleticism; LUSC cis rs314370 0.951 rs12667888 chr7:100474289 T/C cg18683606 chr7:100471612 SRRT 0.45 5.96 0.31 6.4e-9 Resting heart rate; LUSC cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg24642439 chr20:33292090 TP53INP2 0.49 7.4 0.38 1.09e-12 Glomerular filtration rate (creatinine); LUSC cis rs7809950 0.773 rs2237668 chr7:107050209 A/G cg23024343 chr7:107201750 COG5 -0.7 -10.08 -0.48 4.85e-21 Coronary artery disease; LUSC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg11752832 chr7:134001865 SLC35B4 0.59 9.3 0.45 1.95e-18 Mean platelet volume; LUSC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg11941060 chr3:133502564 NA -0.42 -6.13 -0.32 2.47e-9 Iron status biomarkers; LUSC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg20933634 chr6:27740509 NA 0.4 5.87 0.31 1.06e-8 Parkinson's disease; LUSC cis rs7223966 1.000 rs8067064 chr17:61825984 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 7.04 0.36 1.08e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1595825 0.735 rs6752454 chr2:198938959 T/G cg00982548 chr2:198649783 BOLL -0.54 -6.48 -0.33 3.2e-10 Ulcerative colitis; LUSC trans rs3733585 0.699 rs7676733 chr4:9966956 G/A cg26043149 chr18:55253948 FECH -0.46 -7.07 -0.36 8.95e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs61931739 0.500 rs34080094 chr12:34547952 G/A cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg01849466 chr14:104193079 ZFYVE21 -0.59 -9.63 -0.47 1.6e-19 Schizophrenia; LUSC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg22823121 chr1:150693482 HORMAD1 0.6 9.34 0.46 1.35e-18 Tonsillectomy; LUSC cis rs7927592 0.913 rs59056571 chr11:68272973 T/G cg20283391 chr11:68216788 NA -0.61 -8.56 -0.42 4.21e-16 Total body bone mineral density; LUSC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg06008330 chr7:65541103 ASL 0.37 5.68 0.3 2.97e-8 Aortic root size; LUSC cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg15839431 chr19:19639596 YJEFN3 -0.63 -7.15 -0.36 5.48e-12 Bipolar disorder; LUSC trans rs12637928 0.560 rs11923659 chr3:110295279 T/A cg17371621 chr15:61264283 RORA -0.37 -6.0 -0.31 5.25e-9 Neuroticism; LUSC cis rs7592578 0.639 rs61709084 chr2:191287685 A/C cg10560079 chr2:191398806 TMEM194B -0.63 -8.04 -0.4 1.55e-14 Diastolic blood pressure; LUSC cis rs950027 0.549 rs2899375 chr15:45598335 G/A cg09092052 chr15:45571596 NA 0.47 6.64 0.34 1.25e-10 Response to fenofibrate (adiponectin levels); LUSC cis rs9399135 0.935 rs987690 chr6:135350379 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.14 0.45 6.29e-18 Red blood cell count; LUSC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg16743903 chr16:89593216 SPG7 -0.37 -5.71 -0.3 2.52e-8 Multiple myeloma (IgH translocation); LUSC cis rs7250872 0.647 rs2304613 chr19:1817943 G/C cg02747822 chr19:1826707 REXO1 0.38 6.03 0.31 4.44e-9 Bipolar disorder; LUSC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg17971929 chr21:40555470 PSMG1 -0.48 -7.2 -0.37 4.1e-12 Menarche (age at onset); LUSC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs5167 0.566 rs7253458 chr19:45482570 C/T cg25746394 chr19:45450501 APOC2 0.32 6.07 0.32 3.55e-9 Blood protein levels; LUSC cis rs6714710 0.603 rs953320 chr2:98606770 T/C cg26665480 chr2:98280029 ACTR1B 0.62 8.83 0.44 5.97e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg06481639 chr22:41940642 POLR3H -0.55 -6.12 -0.32 2.63e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs10207060 0.500 rs72992168 chr2:240712932 G/A cg20333904 chr2:240724165 NA -0.35 -6.15 -0.32 2.26e-9 Obesity-related traits; LUSC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg17971929 chr21:40555470 PSMG1 0.71 11.05 0.52 2.1e-24 Cognitive function; LUSC trans rs587847 0.507 rs1457248 chr15:37793115 G/A cg18296784 chr11:116147929 NA -0.36 -6.33 -0.33 7.71e-10 Intraocular pressure; LUSC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg20573242 chr4:122745356 CCNA2 0.59 8.48 0.42 7.16e-16 Type 2 diabetes; LUSC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg20399509 chr21:47717575 C21orf57 -0.43 -6.18 -0.32 1.88e-9 Testicular germ cell tumor; LUSC cis rs6546537 1.000 rs4852868 chr2:69831636 C/T cg10773587 chr2:69614142 GFPT1 -0.44 -7.2 -0.37 3.98e-12 Serum thyroid-stimulating hormone levels; LUSC cis rs11190604 1.000 rs2495752 chr10:102326115 T/C cg16342193 chr10:102329863 NA -0.38 -6.43 -0.33 4.33e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9303401 0.573 rs34097494 chr17:57171917 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.82 12.4 0.56 2.57e-29 Cognitive test performance; LUSC cis rs7829975 0.626 rs332040 chr8:8730488 G/A cg06636001 chr8:8085503 FLJ10661 0.69 10.95 0.51 4.61e-24 Mood instability; LUSC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.16 -0.36 5.24e-12 Major depressive disorder; LUSC cis rs73206853 0.841 rs55634798 chr12:110833748 G/T cg12870014 chr12:110450643 ANKRD13A 0.67 6.73 0.35 7.44e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg09555818 chr19:45449301 APOC2 0.47 8.83 0.44 5.84e-17 Blood protein levels; LUSC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg09359103 chr1:154839909 KCNN3 -0.72 -16.97 -0.68 4.99e-47 Prostate cancer; LUSC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.97 -0.4 2.53e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg09491104 chr22:46646882 C22orf40 -0.67 -7.0 -0.36 1.42e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs17270561 0.609 rs2000350 chr6:25763154 T/C cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs614226 1.000 rs1614223 chr12:120964043 T/C cg27489772 chr12:121021490 NA 0.58 7.75 0.39 1.11e-13 Type 1 diabetes nephropathy; LUSC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg17366294 chr4:99064904 C4orf37 0.6 10.73 0.51 2.82e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.966 rs4813557 chr20:25292545 C/T cg03522245 chr20:25566470 NINL -0.36 -5.8 -0.3 1.54e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.06 -0.36 9.79e-12 Lung cancer; LUSC cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg25019033 chr10:957182 NA -0.58 -7.61 -0.38 2.75e-13 Eosinophil percentage of granulocytes; LUSC cis rs1376877 0.519 rs12466364 chr2:204226331 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.5 6.43 0.33 4.33e-10 Subclinical atherosclerosis traits (other); LUSC cis rs10791323 0.693 rs10750544 chr11:133718740 A/G cg00579200 chr11:133705235 NA -0.4 -6.14 -0.32 2.33e-9 Childhood ear infection; LUSC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.08 -0.4 1.19e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg09365446 chr1:150670422 GOLPH3L 0.44 6.33 0.33 7.88e-10 Melanoma; LUSC cis rs7086627 0.515 rs7907969 chr10:82153005 T/A cg00277334 chr10:82204260 NA -0.59 -9.81 -0.47 4.05e-20 Post bronchodilator FEV1; LUSC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg22834771 chr12:69754056 YEATS4 -0.55 -8.13 -0.41 8.34e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg20295408 chr7:1910781 MAD1L1 0.4 5.67 0.3 3.15e-8 Bipolar disorder and schizophrenia; LUSC cis rs2760061 0.583 rs3094911 chr1:228210179 A/G cg20976159 chr1:228193529 WNT3A 0.29 5.71 0.3 2.54e-8 Diastolic blood pressure; LUSC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.07 0.52 1.74e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1982963 1.000 rs4901186 chr14:52509484 G/A cg10843707 chr14:52510701 NID2 -0.39 -6.75 -0.35 6.38e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7681440 0.647 rs6824979 chr4:90819407 C/G cg01966878 chr4:90757139 SNCA 0.35 5.65 0.3 3.44e-8 Dementia with Lewy bodies; LUSC trans rs1973993 0.691 rs2985636 chr1:96889884 T/A cg10631902 chr5:14652156 NA 0.6 10.79 0.51 1.8e-23 Weight; LUSC cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg10523679 chr1:76189770 ACADM 0.75 10.12 0.48 3.56e-21 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs11098499 0.954 rs3733519 chr4:120423448 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 3.83e-10 Corneal astigmatism; LUSC cis rs12618769 0.597 rs55900716 chr2:99109132 G/A cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg14092988 chr3:52407081 DNAH1 0.31 6.18 0.32 1.82e-9 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09659514 chr21:33765299 URB1;C21orf119 -0.4 -5.98 -0.31 5.79e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs757278 0.591 rs34637736 chr7:117294301 C/T cg10524701 chr7:117356490 CTTNBP2 0.41 5.82 0.3 1.38e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC trans rs4662863 0.566 rs17049012 chr2:129767539 G/A cg05506011 chr3:118864587 C3orf30;IGSF11 0.36 6.03 0.31 4.38e-9 Gut microbiome composition (winter); LUSC cis rs4478858 0.684 rs1532861 chr1:31766491 T/C cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.19e-15 Alcohol dependence; LUSC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg18252515 chr7:66147081 NA -1.19 -12.97 -0.58 2.03e-31 Diabetic kidney disease; LUSC cis rs79911532 0.515 rs76083953 chr7:75698576 G/C cg03592824 chr7:75666768 STYXL1 0.67 6.41 0.33 4.98e-10 Mononucleosis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09916155 chr16:1728187 HN1L 0.75 5.96 0.31 6.26e-9 Cognitive performance; LUSC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg09165964 chr15:75287851 SCAMP5 -1.01 -15.3 -0.64 2.03e-40 Blood trace element (Zn levels); LUSC cis rs56176327 0.600 rs7628207 chr3:49754970 T/C cg03060546 chr3:49711283 APEH 0.64 7.54 0.38 4.41e-13 Intelligence (multi-trait analysis); LUSC cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg24642439 chr20:33292090 TP53INP2 -0.48 -7.33 -0.37 1.7e-12 Glomerular filtration rate (creatinine); LUSC cis rs17401966 0.540 rs11121557 chr1:10448260 T/G cg17425144 chr1:10567563 PEX14 -0.34 -6.03 -0.31 4.3e-9 Hepatocellular carcinoma; LUSC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg14780466 chr2:20870812 GDF7 -0.39 -7.79 -0.39 8.53e-14 Abdominal aortic aneurysm; LUSC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg08847533 chr14:75593920 NEK9 -0.82 -14.81 -0.63 1.74e-38 Height; LUSC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg09359103 chr1:154839909 KCNN3 -0.7 -15.74 -0.65 3.72e-42 Prostate cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18642567 chr14:21755798 RPGRIP1 0.48 6.03 0.31 4.39e-9 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg13395646 chr4:1353034 KIAA1530 -0.78 -13.02 -0.58 1.21e-31 Obesity-related traits; LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.35 0.37 1.57e-12 Bipolar disorder; LUSC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.92 -0.35 2.29e-11 Lung cancer; LUSC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg03213289 chr20:61660250 NA 0.68 14.05 0.61 1.46e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs4974559 0.690 rs28515563 chr4:1315123 G/A cg02980000 chr4:1222292 CTBP1 1.01 9.53 0.46 3.42e-19 Systolic blood pressure; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg10298173 chr3:14166327 CHCHD4;TMEM43 0.44 6.86 0.35 3.38e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs500891 0.525 rs13198062 chr6:84075281 C/T cg08257003 chr6:84140564 ME1 0.34 8.32 0.41 2.2e-15 Platelet-derived growth factor BB levels; LUSC cis rs7659604 0.643 rs6839054 chr4:122663628 C/T cg06713675 chr4:122721982 EXOSC9 -0.45 -7.06 -0.36 9.99e-12 Type 2 diabetes; LUSC cis rs61142792 0.590 rs747861 chr5:177037397 C/G cg15051221 chr5:177434457 FAM153C 0.65 5.98 0.31 5.72e-9 Alzheimer disease and age of onset; LUSC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg07936489 chr17:37558343 FBXL20 -0.71 -9.99 -0.48 9.76e-21 Glomerular filtration rate (creatinine); LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13126279 chr21:47581558 C21orf56 -0.56 -8.56 -0.42 4.05e-16 Testicular germ cell tumor; LUSC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg23422044 chr7:1970798 MAD1L1 -0.65 -7.31 -0.37 2.04e-12 Bipolar disorder; LUSC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11644478 chr21:40555479 PSMG1 0.96 19.47 0.73 5.67e-57 Cognitive function; LUSC cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg00677455 chr12:58241039 CTDSP2 0.61 9.02 0.44 1.5e-17 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg08280861 chr8:58055591 NA 0.52 5.68 0.3 2.99e-8 Developmental language disorder (linguistic errors); LUSC trans rs6502050 0.731 rs11867299 chr17:80088675 C/A cg07393940 chr7:158741817 NA 0.37 6.7 0.34 8.88e-11 Life satisfaction; LUSC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.61 0.47 1.76e-19 Personality dimensions; LUSC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg25427524 chr10:38739819 LOC399744 -0.67 -12.09 -0.55 3.73e-28 Extrinsic epigenetic age acceleration; LUSC cis rs2072499 0.833 rs2842873 chr1:156204653 C/T cg24450063 chr1:156163899 SLC25A44 1.11 24.5 0.8 1.4e-76 Testicular germ cell tumor; LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg08132940 chr7:1081526 C7orf50 -0.52 -6.15 -0.32 2.27e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4423214 1.000 rs2276361 chr11:71169648 A/G cg05163923 chr11:71159392 DHCR7 0.76 11.26 0.52 3.78e-25 Vitamin D levels; LUSC cis rs1994135 0.654 rs1447872 chr12:33718343 C/A cg06521331 chr12:34319734 NA -0.4 -5.76 -0.3 1.94e-8 Resting heart rate; LUSC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg07701084 chr6:150067640 NUP43 0.53 7.99 0.4 2.17e-14 Lung cancer; LUSC cis rs911119 0.657 rs2104005 chr20:23630761 G/A cg16589663 chr20:23618590 CST3 0.62 6.65 0.34 1.18e-10 Chronic kidney disease; LUSC cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg26408565 chr15:76604113 ETFA -0.44 -7.0 -0.36 1.43e-11 Blood metabolite levels; LUSC cis rs208520 1.000 rs12191598 chr6:66983962 T/C cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs8072100 1.000 rs11650372 chr17:45721795 G/A cg08085267 chr17:45401833 C17orf57 -0.62 -10.43 -0.5 3.01e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg02931644 chr1:25747376 RHCE 0.35 6.33 0.33 8.07e-10 Erythrocyte sedimentation rate; LUSC cis rs11264799 0.520 rs849826 chr1:157546346 A/T cg18268488 chr1:157545234 FCRL4 0.41 8.21 0.41 4.88e-15 IgA nephropathy; LUSC cis rs6088580 0.505 rs6058106 chr20:33278255 T/C cg24642439 chr20:33292090 TP53INP2 -0.54 -8.16 -0.41 7.03e-15 Glomerular filtration rate (creatinine); LUSC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 5.85 0.3 1.18e-8 Menopause (age at onset); LUSC cis rs478304 0.651 rs11600918 chr11:65511965 A/G cg10518572 chr11:65560635 OVOL1 -0.26 -5.93 -0.31 7.37e-9 Acne (severe); LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg02423579 chr7:2872169 GNA12 -0.47 -6.59 -0.34 1.76e-10 Height; LUSC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.67 -0.39 1.85e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs698813 0.637 rs7579841 chr2:44498887 T/A cg00619915 chr2:44497795 NA -0.52 -7.29 -0.37 2.26e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs72674100 1.000 rs2865753 chr4:97992752 A/T cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg26314531 chr2:26401878 FAM59B -0.69 -9.3 -0.45 1.91e-18 Gut microbiome composition (summer); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10684905 chr12:2999782 TULP3 0.42 6.83 0.35 4.01e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg25174290 chr11:3078921 CARS -0.56 -8.77 -0.43 9.35e-17 Longevity; LUSC cis rs7089973 0.624 rs11196940 chr10:116593791 T/G cg25233709 chr10:116636983 FAM160B1 0.38 6.68 0.34 1.03e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1023500 0.552 rs5758566 chr22:42454354 G/A cg05082376 chr22:42548792 NA -0.38 -5.8 -0.3 1.57e-8 Schizophrenia; LUSC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg11062466 chr8:58055876 NA 0.5 6.72 0.35 7.7e-11 Developmental language disorder (linguistic errors); LUSC cis rs4356932 0.967 rs6856681 chr4:76975113 G/A cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs1881396 0.531 rs76586169 chr2:27897835 G/A cg27432699 chr2:27873401 GPN1 0.63 7.51 0.38 5.33e-13 Nonalcoholic fatty liver disease; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg22166914 chr1:53195759 ZYG11B 0.43 6.79 0.35 5.15e-11 Monocyte count; LUSC cis rs17401966 0.540 rs1536262 chr1:10438687 C/T cg19773385 chr1:10388646 KIF1B -0.37 -6.29 -0.33 9.98e-10 Hepatocellular carcinoma; LUSC cis rs56104184 0.830 rs55966626 chr19:49342396 G/T cg15549821 chr19:49342101 PLEKHA4 -0.88 -11.25 -0.52 4.06e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs734999 0.588 rs60520190 chr1:2533706 G/A cg18932078 chr1:2524107 MMEL1 0.32 7.2 0.37 4e-12 Ulcerative colitis; LUSC cis rs35883536 0.647 rs2783703 chr1:101040794 T/C cg09408571 chr1:101003634 GPR88 0.29 5.67 0.3 3.12e-8 Monocyte count; LUSC cis rs7568458 0.684 rs7593969 chr2:85809670 A/G cg17127132 chr2:85788382 GGCX -0.42 -6.08 -0.32 3.3e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2302729 1.000 rs7974589 chr12:2785089 G/A cg19945202 chr12:2788847 CACNA1C -0.39 -5.99 -0.31 5.57e-9 Sleep quality; LUSC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.09 -0.36 8.23e-12 Lung cancer; LUSC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg03354898 chr7:1950403 MAD1L1 0.34 6.67 0.34 1.09e-10 Bipolar disorder and schizophrenia; LUSC cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg04450456 chr4:17643702 FAM184B 0.35 5.85 0.3 1.18e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg16393715 chr7:1948819 MAD1L1 -0.33 -5.71 -0.3 2.51e-8 Bipolar disorder and schizophrenia; LUSC cis rs11105298 0.891 rs10858872 chr12:89872932 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.22 -0.37 3.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs67696533 0.600 rs910890 chr20:31108932 G/T cg13636640 chr20:31349939 DNMT3B 0.49 6.68 0.34 1.03e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9462027 0.606 rs7756009 chr6:34715395 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.9 -0.31 9.02e-9 Systemic lupus erythematosus; LUSC cis rs12594515 1.000 rs12592190 chr15:45994028 G/A cg06207120 chr15:45996521 NA 0.38 5.75 0.3 2.02e-8 Waist circumference;Weight; LUSC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg17279839 chr7:150038598 RARRES2 0.45 6.92 0.35 2.34e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg26597838 chr10:835615 NA 1.24 16.51 0.67 3.35e-45 Eosinophil percentage of granulocytes; LUSC cis rs6696846 0.715 rs61822659 chr1:205142847 G/A cg03948781 chr1:205179583 DSTYK 0.32 6.1 0.32 2.98e-9 Red blood cell count; LUSC cis rs7246657 0.943 rs12709813 chr19:37844983 G/A cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs17095355 0.818 rs61881639 chr10:111863501 G/A cg00817464 chr10:111662876 XPNPEP1 -0.59 -6.83 -0.35 4.13e-11 Biliary atresia; LUSC cis rs9677476 0.818 rs28678038 chr2:232063997 A/T cg07929768 chr2:232055508 NA 0.37 6.85 0.35 3.49e-11 Food antigen IgG levels; LUSC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC cis rs7267979 0.966 rs6107031 chr20:25350677 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.43 -0.33 4.39e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg09509183 chr1:209979624 IRF6 0.52 6.21 0.32 1.61e-9 Cleft lip with or without cleft palate; LUSC cis rs4474465 0.646 rs10899556 chr11:78278986 C/T cg27205649 chr11:78285834 NARS2 0.56 6.82 0.35 4.31e-11 Alzheimer's disease (survival time); LUSC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg14983838 chr19:29218262 NA 0.66 9.24 0.45 3.02e-18 Methadone dose in opioid dependence; LUSC cis rs3806843 0.518 rs2569191 chr5:140013903 C/T cg26395211 chr5:140044315 WDR55 0.4 6.24 0.32 1.3e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg09034736 chr1:150693464 HORMAD1 0.41 5.75 0.3 1.96e-8 Melanoma; LUSC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.89e-12 Blood metabolite levels; LUSC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg15448220 chr1:150897856 SETDB1 0.41 6.17 0.32 1.97e-9 Melanoma; LUSC cis rs7586879 0.558 rs6718510 chr2:25122323 A/C cg15423357 chr2:25149977 NA 0.45 9.1 0.45 8.6e-18 Body mass index; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg13679077 chr7:22862647 TOMM7 0.41 6.64 0.34 1.28e-10 Tuberculosis; LUSC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg00012203 chr2:219082015 ARPC2 -0.7 -11.43 -0.53 9.14e-26 Colorectal cancer; LUSC cis rs6087990 0.735 rs2424906 chr20:31359109 A/G cg13636640 chr20:31349939 DNMT3B 0.94 19.64 0.73 1.19e-57 Ulcerative colitis; LUSC trans rs6427356 1.000 rs1176555 chr1:157136541 C/G cg27612695 chr17:29059191 SUZ12P 0.39 5.96 0.31 6.39e-9 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs57549656 0.799 rs72980732 chr19:2711278 A/G cg06609049 chr19:2785107 THOP1 0.49 6.43 0.33 4.51e-10 Schizophrenia; LUSC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg01368799 chr11:117014884 PAFAH1B2 0.51 6.72 0.35 7.83e-11 Blood protein levels; LUSC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg04851639 chr8:1020857 NA 0.37 7.67 0.39 1.94e-13 Schizophrenia; LUSC cis rs7246657 0.943 rs9917081 chr19:37876616 T/C cg23950597 chr19:37808831 NA -0.63 -7.52 -0.38 5.22e-13 Coronary artery calcification; LUSC cis rs11676348 0.774 rs13397673 chr2:219047782 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.89 -0.31 9.22e-9 Ulcerative colitis; LUSC cis rs2108225 0.934 rs2301988 chr7:107443833 A/G cg18560240 chr7:107437656 SLC26A3 0.39 5.83 0.3 1.28e-8 Ulcerative colitis; LUSC cis rs4285028 0.747 rs1128163 chr3:121350573 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.41 -0.56 2.48e-29 Multiple sclerosis; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg26338869 chr17:61819248 STRADA 0.41 5.95 0.31 6.66e-9 Prudent dietary pattern; LUSC cis rs6121246 0.559 rs6060922 chr20:30333909 C/T cg13852791 chr20:30311386 BCL2L1 0.95 14.9 0.63 7.51e-39 Mean corpuscular hemoglobin; LUSC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg22920501 chr2:26401640 FAM59B -0.74 -10.57 -0.5 1.01e-22 Gut microbiome composition (summer); LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg16405210 chr4:1374714 KIAA1530 -0.55 -8.42 -0.42 1.16e-15 Obesity-related traits; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.32e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1008375 0.900 rs13101742 chr4:17701297 G/A cg04450456 chr4:17643702 FAM184B -0.36 -5.66 -0.3 3.33e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11190604 0.767 rs11190509 chr10:102156208 G/A cg07080220 chr10:102295463 HIF1AN 0.6 7.75 0.39 1.15e-13 Palmitoleic acid (16:1n-7) levels; LUSC trans rs12677056 0.610 rs6992196 chr8:113287399 A/T cg12159992 chr12:102059490 MYBPC1 0.37 6.17 0.32 1.93e-9 Peripheral artery disease; LUSC cis rs11229555 0.645 rs11229442 chr11:58196790 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs16867321 0.950 rs1919155 chr2:181457053 T/C cg23363182 chr2:181467187 NA -0.44 -5.91 -0.31 8.46e-9 Obesity; LUSC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs67072384 1.000 rs66628852 chr11:72454260 C/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs7766436 0.885 rs13220769 chr6:22596464 T/A cg13666174 chr6:22585274 NA -0.41 -5.72 -0.3 2.4e-8 Coronary artery disease; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg20849893 chr7:64541193 NA -0.44 -6.31 -0.33 8.67e-10 Calcium levels; LUSC trans rs12579753 0.879 rs1986537 chr12:82156475 G/C cg07923666 chr12:49932857 KCNH3 -0.52 -6.74 -0.35 6.79e-11 Resting heart rate; LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg22907277 chr7:1156413 C7orf50 0.4 5.94 0.31 7e-9 Longevity;Endometriosis; LUSC cis rs2273669 0.667 rs1424479 chr6:109355790 G/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs4776059 0.724 rs11633933 chr15:52948357 T/C cg22715398 chr15:52968154 KIAA1370 -0.74 -9.91 -0.48 1.8e-20 Schizophrenia; LUSC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg21535247 chr6:8435926 SLC35B3 0.58 9.0 0.44 1.74e-17 Motion sickness; LUSC cis rs8017423 0.935 rs11628952 chr14:90734953 T/C cg04374321 chr14:90722782 PSMC1 -0.68 -10.26 -0.49 1.17e-21 Mortality in heart failure; LUSC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg02574844 chr11:5959923 NA 0.4 6.64 0.34 1.28e-10 DNA methylation (variation); LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12620999 0.941 rs62183344 chr2:237979165 T/C cg23555395 chr2:238036564 NA 0.45 7.87 0.4 5.05e-14 Systemic lupus erythematosus; LUSC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg09323728 chr8:95962352 TP53INP1 -0.45 -9.18 -0.45 4.76e-18 Type 2 diabetes; LUSC trans rs6600671 1.000 rs12047116 chr1:121185770 G/A cg00646200 chr1:148855367 NA 0.46 7.33 0.37 1.77e-12 Hip geometry; LUSC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg07701084 chr6:150067640 NUP43 0.51 7.65 0.39 2.23e-13 Lung cancer; LUSC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg10802521 chr3:52805072 NEK4 -0.55 -8.97 -0.44 2.18e-17 Electroencephalogram traits; LUSC cis rs2281558 0.583 rs7260957 chr20:25722462 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.51 6.23 0.32 1.42e-9 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs2637266 1.000 rs7101318 chr10:78379780 T/C cg18941641 chr10:78392320 NA 0.38 6.94 0.35 2.08e-11 Pulmonary function; LUSC cis rs365132 1.000 rs601923 chr5:176417386 C/G cg25401027 chr5:176370377 UIMC1 0.37 6.29 0.33 9.95e-10 Menarche and menopause (age at onset);Menopause (age at onset); LUSC trans rs984440 0.621 rs1028779 chr8:139076802 A/G cg03334052 chr1:168888044 NA -0.4 -6.29 -0.33 9.73e-10 Obesity-related traits; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg13272430 chr14:67708475 MPP5 0.43 6.52 0.34 2.67e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg18827107 chr12:86230957 RASSF9 -0.47 -7.06 -0.36 9.92e-12 Major depressive disorder; LUSC cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 7.92 0.4 3.58e-14 Colorectal cancer; LUSC cis rs793571 0.543 rs4775087 chr15:58974904 T/C cg05156742 chr15:59063176 FAM63B 0.52 7.62 0.38 2.61e-13 Schizophrenia; LUSC cis rs887829 0.570 rs10171367 chr2:234597667 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.28 -0.33 1.04e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs4906332 0.811 rs2756138 chr14:103996733 C/G cg04998671 chr14:104000505 TRMT61A 0.57 8.03 0.4 1.69e-14 Coronary artery disease; LUSC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg08508325 chr11:3079039 CARS -0.52 -12.45 -0.56 1.76e-29 Longevity; LUSC cis rs9341808 0.667 rs2322632 chr6:80845608 G/A cg08355045 chr6:80787529 NA 0.47 8.22 0.41 4.62e-15 Sitting height ratio; LUSC cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.9 -0.35 2.68e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs739401 0.611 rs572373 chr11:3055361 T/C cg25174290 chr11:3078921 CARS 0.61 9.6 0.46 2.04e-19 Longevity; LUSC cis rs782590 0.967 rs1823893 chr2:55788921 T/C cg03859395 chr2:55845619 SMEK2 0.88 16.19 0.66 6.22e-44 Metabolic syndrome; LUSC cis rs9462027 0.628 rs2764207 chr6:34712998 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.87 -0.31 1.02e-8 Systemic lupus erythematosus; LUSC cis rs7223966 1.000 rs11657306 chr17:61704822 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.13 0.36 6.25e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs12594515 1.000 rs57299255 chr15:45996532 C/A cg06207120 chr15:45996521 NA 0.39 5.9 0.31 8.78e-9 Waist circumference;Weight; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg06873352 chr17:61820015 STRADA 0.71 12.94 0.58 2.56e-31 Prudent dietary pattern; LUSC trans rs7726839 0.561 rs72703058 chr5:584519 G/A cg25482853 chr8:67687455 SGK3 1.03 15.45 0.65 5.41e-41 Obesity-related traits; LUSC cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.51 7.73 0.39 1.27e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs9784649 0.882 rs2201296 chr5:24967119 G/A cg08600765 chr20:34638493 LOC647979 -0.56 -6.25 -0.32 1.28e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6665290 0.836 rs56029302 chr1:227203390 G/A cg10327440 chr1:227177885 CDC42BPA -1.21 -36.83 -0.9 1.24e-119 Myeloid white cell count; LUSC cis rs7851660 0.874 rs925487 chr9:100636398 C/T cg13688889 chr9:100608707 NA -0.55 -8.68 -0.43 1.77e-16 Strep throat; LUSC cis rs3847687 0.966 rs3847689 chr12:131525534 T/G cg25772418 chr12:131519998 GPR133 -0.26 -5.81 -0.3 1.44e-8 Longevity; LUSC cis rs2281845 0.965 rs3738262 chr1:201083343 A/G cg22815214 chr1:201083145 CACNA1S 0.57 10.05 0.48 6.06e-21 Permanent tooth development; LUSC cis rs7267979 0.789 rs6050472 chr20:25219852 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.68 12.75 0.57 1.35e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg13395646 chr4:1353034 KIAA1530 -0.78 -13.08 -0.58 7.57e-32 Obesity-related traits; LUSC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg20476274 chr7:133979776 SLC35B4 0.86 16.57 0.67 1.92e-45 Mean platelet volume; LUSC cis rs12579753 0.879 rs12579544 chr12:82164043 A/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.48 -0.33 3.27e-10 Resting heart rate; LUSC cis rs9653442 0.545 rs12987209 chr2:100761148 C/T cg22139774 chr2:100720529 AFF3 -0.42 -7.26 -0.37 2.8e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs3809863 0.602 rs11650072 chr17:45393665 A/G cg25173405 chr17:45401733 C17orf57 -0.49 -7.26 -0.37 2.69e-12 Glaucoma (primary open-angle); LUSC trans rs6598955 0.671 rs11247904 chr1:26621804 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.48 -0.42 7.55e-16 Obesity-related traits; LUSC cis rs7312933 0.558 rs11181422 chr12:42718552 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.84 -0.35 3.74e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6426558 0.559 rs7549520 chr1:227258858 G/C cg10327440 chr1:227177885 CDC42BPA 0.55 7.43 0.38 9.1e-13 Neutrophil percentage of white cells; LUSC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11644478 chr21:40555479 PSMG1 -0.65 -10.18 -0.49 2.21e-21 Menarche (age at onset); LUSC cis rs7746199 0.736 rs13195636 chr6:27509493 A/C cg09904177 chr6:26538194 HMGN4 -0.73 -5.73 -0.3 2.3e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg10802521 chr3:52805072 NEK4 -0.55 -8.78 -0.43 8.36e-17 Bipolar disorder; LUSC cis rs68170813 0.652 rs76742243 chr7:107144202 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.46 -5.69 -0.3 2.79e-8 Coronary artery disease; LUSC cis rs752010 0.808 rs7529858 chr1:42086606 G/C cg06885757 chr1:42089581 HIVEP3 0.48 10.12 0.48 3.59e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs909341 0.909 rs6122159 chr20:62370732 G/T cg09650180 chr20:62225654 GMEB2 -0.44 -5.67 -0.3 3.15e-8 Atopic dermatitis; LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg05025164 chr4:1340916 KIAA1530 0.64 9.63 0.47 1.55e-19 Longevity; LUSC cis rs3849570 1.000 rs9842330 chr3:81814688 G/A cg07356753 chr3:81810745 GBE1 -0.68 -10.94 -0.51 5.14e-24 Waist circumference;Body mass index; LUSC cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg06784218 chr1:46089804 CCDC17 -0.5 -10.06 -0.48 5.91e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3018712 0.532 rs2513289 chr11:68419655 A/C cg22747802 chr11:68417633 NA -0.43 -5.95 -0.31 6.89e-9 Total body bone mineral density; LUSC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg18876405 chr7:65276391 NA -0.7 -12.59 -0.57 5.36e-30 Aortic root size; LUSC cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg11584989 chr19:19387371 SF4 0.68 8.02 0.4 1.86e-14 Bipolar disorder; LUSC cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg05457628 chr5:178986728 RUFY1 -0.65 -11.24 -0.52 4.34e-25 Lung cancer; LUSC cis rs10504073 0.647 rs4873317 chr8:50021111 C/T cg00325661 chr8:49890786 NA 0.62 10.04 0.48 6.47e-21 Blood metabolite ratios; LUSC cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg22117172 chr7:91764530 CYP51A1 0.32 5.67 0.3 3.11e-8 Breast cancer; LUSC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg16423285 chr20:60520624 NA -0.91 -12.63 -0.57 3.6e-30 Obesity-related traits; LUSC cis rs35995292 0.500 rs1019065 chr7:38939775 C/T cg19327137 chr7:38886074 VPS41 0.56 10.4 0.49 3.92e-22 Subjective well-being (multi-trait analysis); LUSC cis rs2455601 0.744 rs2163626 chr11:8983547 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.46 -7.96 -0.4 2.77e-14 Schizophrenia; LUSC cis rs4499344 0.556 rs259219 chr19:33138067 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.83 11.41 0.53 1.09e-25 Mean platelet volume; LUSC cis rs11235843 0.613 rs71464090 chr11:73596791 T/G cg18195628 chr11:73498948 MRPL48 0.53 5.87 0.31 1.07e-8 Hand grip strength; LUSC cis rs1215050 0.791 rs260902 chr4:98764694 G/A cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.25e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 5.84 0.3 1.24e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg03929089 chr4:120376271 NA 0.69 7.78 0.39 9.14e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg13319975 chr6:146136371 FBXO30 -0.51 -7.67 -0.39 1.9e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg23649088 chr2:200775458 C2orf69 0.55 7.38 0.37 1.26e-12 Schizophrenia; LUSC cis rs11122272 0.701 rs1009227 chr1:231480507 A/G cg06096015 chr1:231504339 EGLN1 0.57 10.02 0.48 7.85e-21 Hemoglobin concentration; LUSC cis rs59698941 0.943 rs12516416 chr5:132248630 C/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC trans rs953492 0.644 rs12124014 chr1:243376757 T/C cg25284624 chr1:224180302 NA -0.44 -6.8 -0.35 4.96e-11 Diastolic blood pressure; LUSC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9653442 0.704 rs10211595 chr2:100726476 G/C cg07810366 chr2:100720526 AFF3 -0.48 -8.06 -0.4 1.4e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1348850 0.526 rs10497504 chr2:178370040 T/C cg22681709 chr2:178499509 PDE11A -0.45 -6.65 -0.34 1.19e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9325144 0.647 rs61931899 chr12:38892422 A/G cg13010199 chr12:38710504 ALG10B -0.49 -7.4 -0.38 1.11e-12 Morning vs. evening chronotype; LUSC cis rs9479482 0.935 rs9479507 chr6:150366514 T/G cg25797454 chr6:150327115 RAET1K 0.32 7.26 0.37 2.78e-12 Alopecia areata; LUSC cis rs11039100 0.850 rs12792672 chr11:5833938 C/T cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1559088 0.739 rs9304845 chr19:33592794 A/G cg27124370 chr19:33622961 WDR88 0.57 7.35 0.37 1.51e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs9467711 0.659 rs13220261 chr6:26499185 C/T cg06606381 chr12:133084897 FBRSL1 -0.75 -6.58 -0.34 1.87e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs8027181 1.000 rs7166595 chr15:73094204 A/G cg25632853 chr15:73088954 NA 0.32 6.29 0.33 9.79e-10 Triglyceride levels; LUSC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.68e-21 Electroencephalogram traits; LUSC cis rs4903604 0.581 rs11159279 chr14:78036358 C/T cg18872420 chr14:78023429 SPTLC2 0.39 5.95 0.31 6.78e-9 Gut microbiome composition (winter); LUSC cis rs3820928 0.904 rs4439949 chr2:227764954 T/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.8 -0.39 8.08e-14 Pulmonary function; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg13395646 chr4:1353034 KIAA1530 -0.64 -10.11 -0.48 3.97e-21 Obesity-related traits; LUSC cis rs7267979 0.966 rs2257233 chr20:25265984 A/C cg08601574 chr20:25228251 PYGB -0.44 -6.68 -0.34 1.02e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs757278 0.591 rs34927137 chr7:117294730 C/T cg10524701 chr7:117356490 CTTNBP2 0.4 5.7 0.3 2.63e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs12458462 0.859 rs34242155 chr18:77425192 G/A cg11879182 chr18:77439856 CTDP1 0.72 11.56 0.53 3.13e-26 Monocyte count; LUSC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg10802521 chr3:52805072 NEK4 -0.54 -8.89 -0.44 3.84e-17 Bipolar disorder; LUSC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg02782426 chr3:40428986 ENTPD3 0.39 7.55 0.38 4.09e-13 Renal cell carcinoma; LUSC cis rs12950390 0.853 rs4794107 chr17:45843159 T/G cg06532163 chr17:45867833 NA 0.34 6.2 0.32 1.64e-9 IgG glycosylation; LUSC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg22029157 chr1:209979665 IRF6 0.74 10.99 0.52 3.49e-24 Cleft lip with or without cleft palate; LUSC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.67 10.75 0.51 2.36e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7633770 0.769 rs2385858 chr3:46660436 T/C cg11219411 chr3:46661640 NA 0.48 10.12 0.48 3.62e-21 Coronary artery disease; LUSC cis rs11630290 0.592 rs11071767 chr15:64154635 A/G cg12036633 chr15:63758958 NA -0.5 -6.38 -0.33 5.78e-10 Iris characteristics; LUSC cis rs6121246 0.529 rs2889528 chr20:30210021 C/T cg13852791 chr20:30311386 BCL2L1 0.77 8.73 0.43 1.25e-16 Mean corpuscular hemoglobin; LUSC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg22467129 chr15:76604101 ETFA -0.45 -7.07 -0.36 9.02e-12 Blood metabolite levels; LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6906287 0.561 rs2078079 chr6:118705213 G/A cg21191810 chr6:118973309 C6orf204 0.36 6.56 0.34 2.11e-10 Electrocardiographic conduction measures; LUSC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.54e-21 Electroencephalogram traits; LUSC cis rs2282300 0.696 rs1222214 chr11:30347695 C/G cg25418670 chr11:30344373 C11orf46 -0.64 -9.18 -0.45 4.63e-18 Morning vs. evening chronotype; LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg02475777 chr4:1388615 CRIPAK 0.39 5.81 0.3 1.44e-8 Longevity; LUSC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg12615879 chr12:58013172 SLC26A10 -0.29 -5.94 -0.31 7.18e-9 Multiple sclerosis; LUSC cis rs7674212 0.541 rs2615539 chr4:104081106 C/G cg16532752 chr4:104119610 CENPE -0.5 -7.31 -0.37 1.99e-12 Type 2 diabetes; LUSC cis rs7824557 0.843 rs2572418 chr8:11113089 G/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.77 -0.3 1.83e-8 Retinal vascular caliber; LUSC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg18306943 chr3:40428807 ENTPD3 0.4 6.01 0.31 4.99e-9 Renal cell carcinoma; LUSC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg13114125 chr14:105738426 BRF1 -0.93 -16.05 -0.66 2.2e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.09 -0.32 3.1e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs250677 0.687 rs250679 chr5:148434952 A/T cg18129178 chr5:148520854 ABLIM3 0.54 8.57 0.42 3.91e-16 Breast cancer; LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs6500395 0.962 rs1872652 chr16:48642928 C/A cg04672837 chr16:48644449 N4BP1 0.46 6.36 0.33 6.52e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6987853 0.830 rs4361746 chr8:42355041 C/T cg09913449 chr8:42400586 C8orf40 -0.4 -6.65 -0.34 1.2e-10 Mean corpuscular hemoglobin concentration; LUSC cis rs77633900 0.772 rs8031378 chr15:76657874 A/G cg21673338 chr15:77095150 SCAPER -0.68 -6.0 -0.31 5.2e-9 Non-glioblastoma glioma;Glioma; LUSC trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg15934090 chr1:100435551 SLC35A3 0.48 8.26 0.41 3.47e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs117352156 0.883 rs4587639 chr10:29213174 A/T cg06394621 chr10:29236369 NA -0.48 -6.49 -0.33 3.09e-10 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg02269571 chr22:50332266 NA 0.58 8.69 0.43 1.65e-16 Schizophrenia; LUSC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 9.09 0.45 8.97e-18 Tonsillectomy; LUSC cis rs739401 0.572 rs389128 chr11:3083873 G/T cg05729581 chr11:3078854 CARS -0.54 -8.21 -0.41 4.86e-15 Longevity; LUSC cis rs7851660 0.839 rs10818213 chr9:100648631 T/C cg13688889 chr9:100608707 NA -0.56 -8.44 -0.42 9.94e-16 Strep throat; LUSC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.94 0.44 2.77e-17 Height; LUSC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg11861562 chr11:117069780 TAGLN -0.45 -7.97 -0.4 2.5e-14 Blood protein levels; LUSC trans rs800082 1.000 rs1405596 chr3:144314033 C/G cg24215973 chr2:240111563 HDAC4 -0.45 -6.98 -0.36 1.63e-11 Smoking behavior; LUSC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg14581129 chr12:53358946 NA -0.72 -10.16 -0.49 2.66e-21 Cancer (pleiotropy); LUSC cis rs478304 0.651 rs10896038 chr11:65505528 G/C cg05805236 chr11:65401703 PCNXL3 -0.57 -9.35 -0.46 1.26e-18 Acne (severe); LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg20607798 chr8:58055168 NA -0.56 -5.97 -0.31 5.98e-9 Developmental language disorder (linguistic errors); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg04847795 chr1:70820736 HHLA3;ANKRD13C 0.35 6.06 0.31 3.62e-9 Schizophrenia; LUSC cis rs4285028 0.747 rs10049060 chr3:121358448 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.9 12.85 0.58 5.44e-31 Multiple sclerosis; LUSC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.05 -0.48 6.28e-21 Menarche (age at onset); LUSC cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg15556689 chr8:8085844 FLJ10661 0.66 10.99 0.52 3.57e-24 Mood instability; LUSC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC cis rs9326248 0.539 rs660443 chr11:116760693 T/C cg20608306 chr11:116969690 SIK3 0.37 6.92 0.35 2.32e-11 Blood protein levels; LUSC cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg15073853 chr19:18549131 ISYNA1 -0.32 -5.67 -0.3 3.12e-8 Breast cancer; LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg13531842 chr10:38383804 ZNF37A 0.45 7.0 0.36 1.39e-11 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg11764359 chr7:65958608 NA 0.52 6.87 0.35 3.16e-11 Aortic root size; LUSC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg21521518 chr4:53727714 RASL11B 0.44 5.83 0.3 1.32e-8 Optic nerve measurement (cup area); LUSC cis rs208515 0.525 rs1351866 chr6:66696969 A/G cg07460842 chr6:66804631 NA 1.08 14.62 0.62 9.38e-38 Exhaled nitric oxide levels; LUSC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.49 6.22 0.32 1.48e-9 Multiple sclerosis; LUSC trans rs7726839 0.561 rs4957049 chr5:579080 C/A cg11887960 chr12:57824829 NA 0.51 6.69 0.34 9.16e-11 Obesity-related traits; LUSC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg06108461 chr20:60628389 TAF4 -1.0 -16.81 -0.68 2.25e-46 Body mass index; LUSC cis rs6541297 1.000 rs6686054 chr1:230282853 C/T cg05784532 chr1:230284198 GALNT2 0.5 7.45 0.38 8.02e-13 Coronary artery disease; LUSC cis rs7216064 1.000 rs58122682 chr17:65876915 T/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg02269571 chr22:50332266 NA -0.57 -8.69 -0.43 1.68e-16 Schizophrenia; LUSC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg24829409 chr8:58192753 C8orf71 -0.56 -7.08 -0.36 8.49e-12 Developmental language disorder (linguistic errors); LUSC cis rs7106204 0.514 rs7123539 chr11:24272000 G/A ch.11.24196551F chr11:24239977 NA -0.84 -8.13 -0.41 8.38e-15 Response to Homoharringtonine (cytotoxicity); LUSC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg00990874 chr7:1149470 C7orf50 0.53 6.87 0.35 3.24e-11 Bronchopulmonary dysplasia; LUSC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg25036284 chr2:26402008 FAM59B -0.69 -9.34 -0.46 1.42e-18 Gut microbiome composition (summer); LUSC cis rs7819412 0.521 rs4451268 chr8:11034859 A/G cg21775007 chr8:11205619 TDH -0.44 -6.02 -0.31 4.54e-9 Triglycerides; LUSC cis rs7246657 0.551 rs10407224 chr19:37651470 G/T cg23950597 chr19:37808831 NA -0.59 -6.11 -0.32 2.72e-9 Coronary artery calcification; LUSC cis rs6424115 1.000 rs35385477 chr1:24155924 G/A cg10978503 chr1:24200527 CNR2 0.49 11.53 0.53 4.2e-26 Immature fraction of reticulocytes; LUSC cis rs7904368 0.806 rs12242261 chr10:16872929 T/C cg14835575 chr10:16859367 RSU1 0.76 9.42 0.46 7.86e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs3008870 1.000 rs4620509 chr1:67449941 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs2302729 0.625 rs12228313 chr12:2831297 C/T cg19945202 chr12:2788847 CACNA1C 0.39 5.69 0.3 2.74e-8 Sleep quality; LUSC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg01802117 chr1:53393560 SCP2 -0.36 -5.81 -0.3 1.47e-8 Monocyte count; LUSC trans rs11098499 0.738 rs34965784 chr4:120361586 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.31 0.33 8.78e-10 Corneal astigmatism; LUSC cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg05347473 chr6:146136440 FBXO30 0.47 7.89 0.4 4.25e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs977987 0.806 rs1544810 chr16:75411163 A/T cg03315344 chr16:75512273 CHST6 0.48 9.2 0.45 4.05e-18 Dupuytren's disease; LUSC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg06637938 chr14:75390232 RPS6KL1 0.49 7.57 0.38 3.61e-13 Height; LUSC cis rs892961 0.867 rs312909 chr17:75413954 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.67 0.47 1.13e-19 Airflow obstruction; LUSC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.16 0.36 5.25e-12 Major depressive disorder; LUSC cis rs477692 1.000 rs473771 chr10:131408155 A/C cg11019008 chr10:131425282 MGMT 0.46 6.94 0.36 2.03e-11 Response to temozolomide; LUSC cis rs67311347 0.577 rs2371129 chr3:40248393 C/T cg17264618 chr3:40429014 ENTPD3 -0.26 -5.74 -0.3 2.16e-8 Renal cell carcinoma; LUSC cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg08917208 chr2:24149416 ATAD2B 0.53 5.97 0.31 6e-9 Lymphocyte counts; LUSC cis rs2227930 0.506 rs7647329 chr3:142075505 G/A cg16271453 chr3:142027066 XRN1 -0.55 -9.93 -0.48 1.57e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs7103648 0.669 rs7114011 chr11:47811309 A/C cg20307385 chr11:47447363 PSMC3 0.8 12.26 0.56 9.03e-29 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs6733011 0.508 rs925887 chr2:99514671 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.41 5.85 0.3 1.18e-8 Bipolar disorder; LUSC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg12963246 chr6:28129442 ZNF389 0.38 5.76 0.3 1.9e-8 Cardiac Troponin-T levels; LUSC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg11843238 chr5:131593191 PDLIM4 0.33 5.73 0.3 2.24e-8 Breast cancer; LUSC cis rs4604732 0.631 rs1106720 chr1:247624681 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs11098499 0.697 rs11941899 chr4:120382758 C/A cg24375607 chr4:120327624 NA 0.79 11.69 0.54 1.03e-26 Corneal astigmatism; LUSC cis rs9399135 0.935 rs987690 chr6:135350379 A/G cg22676075 chr6:135203613 NA 0.47 7.37 0.37 1.32e-12 Red blood cell count; LUSC cis rs2717559 0.522 rs35816096 chr8:143884938 C/T cg02415014 chr8:143852576 LYNX1 0.33 7.71 0.39 1.45e-13 Urinary tract infection frequency; LUSC cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg06784218 chr1:46089804 CCDC17 -0.58 -11.58 -0.54 2.66e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg06547715 chr2:218990976 CXCR2 -0.33 -6.36 -0.33 6.73e-10 Ulcerative colitis; LUSC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg26513180 chr16:89883248 FANCA -0.54 -7.97 -0.4 2.5e-14 Vitiligo; LUSC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs6012953 1.000 rs6020572 chr20:49128240 G/A cg13958625 chr20:49123093 NA 0.31 6.63 0.34 1.33e-10 Vitiligo; LUSC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg18827107 chr12:86230957 RASSF9 -0.49 -7.46 -0.38 7.58e-13 Major depressive disorder; LUSC cis rs7107174 1.000 rs2510037 chr11:77966099 A/G cg02023728 chr11:77925099 USP35 0.49 7.29 0.37 2.26e-12 Testicular germ cell tumor; LUSC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03900355 chr11:64521088 PYGM -0.42 -6.07 -0.32 3.5e-9 Thyroid stimulating hormone; LUSC trans rs9860340 0.730 rs67302043 chr3:87641033 T/C cg03644585 chr7:884825 UNC84A 0.42 6.06 0.31 3.62e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7607369 0.714 rs1344643 chr2:219584975 G/C cg02176678 chr2:219576539 TTLL4 -0.65 -12.62 -0.57 3.98e-30 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs6964587 0.934 rs1544377 chr7:91687351 A/G cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs6964587 0.626 rs4422709 chr7:91510968 A/G cg17063962 chr7:91808500 NA -0.54 -8.86 -0.44 4.85e-17 Breast cancer; LUSC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg11812906 chr14:75593930 NEK9 -0.65 -11.19 -0.52 6.48e-25 Height; LUSC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.35 0.53 1.8e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7590368 1.000 rs72779469 chr2:10963764 C/G cg15705551 chr2:10952987 PDIA6 0.56 7.75 0.39 1.14e-13 Educational attainment (years of education); LUSC trans rs7937682 0.632 rs10891294 chr11:111699224 C/T cg18187862 chr3:45730750 SACM1L -0.52 -6.32 -0.33 8.33e-10 Primary sclerosing cholangitis; LUSC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -12.68 -0.57 2.3e-30 Hemoglobin concentration; LUSC cis rs9549260 0.727 rs4603422 chr13:41148353 T/C cg21288729 chr13:41239152 FOXO1 0.6 9.39 0.46 9.46e-19 Red blood cell count; LUSC trans rs11098499 0.739 rs2203039 chr4:120132347 T/C cg25214090 chr10:38739885 LOC399744 -0.4 -6.13 -0.32 2.46e-9 Corneal astigmatism; LUSC cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg04455712 chr21:45112962 RRP1B 0.46 8.78 0.43 8.92e-17 Mean corpuscular volume; LUSC cis rs7707921 0.723 rs226197 chr5:81574925 G/A cg21483461 chr5:81570383 RPS23 0.39 5.65 0.3 3.51e-8 Breast cancer; LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -7.97 -0.4 2.62e-14 Developmental language disorder (linguistic errors); LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg05552183 chr6:42928497 GNMT 0.5 8.33 0.41 2.13e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg13902645 chr11:5959945 NA -0.54 -8.26 -0.41 3.48e-15 DNA methylation (variation); LUSC cis rs2404602 0.692 rs12910734 chr15:77149931 A/G cg22467129 chr15:76604101 ETFA -0.44 -6.89 -0.35 2.85e-11 Blood metabolite levels; LUSC cis rs6582630 0.554 rs7299735 chr12:38450890 A/C cg26384229 chr12:38710491 ALG10B -0.56 -8.35 -0.42 1.85e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs35264875 0.851 rs72930621 chr11:68866745 C/T cg02660097 chr11:68866761 NA 0.42 6.04 0.31 4.12e-9 Blond vs. brown hair color; LUSC cis rs9470366 0.527 rs733590 chr6:36645203 A/G cg08179530 chr6:36648295 CDKN1A 0.6 8.38 0.42 1.54e-15 QRS duration; LUSC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg10802521 chr3:52805072 NEK4 -0.54 -8.71 -0.43 1.43e-16 Bipolar disorder; LUSC cis rs6681460 0.549 rs4655620 chr1:67037194 G/A cg02459107 chr1:67143332 SGIP1 0.31 5.66 0.3 3.25e-8 Presence of antiphospholipid antibodies; LUSC cis rs17154702 0.506 rs28583936 chr8:8647160 C/T cg01851573 chr8:8652454 MFHAS1 0.61 6.47 0.33 3.42e-10 Neurocognitive impairment in HIV-1 infection (continuous); LUSC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.679 rs60869047 chr8:58053221 G/A cg21724239 chr8:58056113 NA 0.56 6.66 0.34 1.13e-10 Developmental language disorder (linguistic errors); LUSC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg10523679 chr1:76189770 ACADM 0.91 14.58 0.62 1.3e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs6500395 1.000 rs7198773 chr16:48606091 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.61 0.34 1.5e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12618769 0.597 rs3754884 chr2:99125376 C/T cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs2479724 0.870 rs7766817 chr6:41918104 T/A cg17623882 chr6:41773611 USP49 -0.58 -9.45 -0.46 5.97e-19 Menarche (age at onset); LUSC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.91 0.4 3.87e-14 Parkinson's disease; LUSC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg11812906 chr14:75593930 NEK9 0.67 11.5 0.53 5.15e-26 Height; LUSC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.92e-10 Life satisfaction; LUSC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg22963979 chr7:1858916 MAD1L1 0.55 8.51 0.42 6.09e-16 Bipolar disorder and schizophrenia; LUSC cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg01579765 chr21:45077557 HSF2BP -0.53 -11.16 -0.52 8.55e-25 Mean corpuscular volume; LUSC cis rs11711311 0.736 rs13320940 chr3:113400954 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.12 0.32 2.66e-9 IgG glycosylation; LUSC cis rs1949733 0.701 rs2688222 chr4:8473735 C/A cg13073564 chr4:8508604 NA -0.44 -8.25 -0.41 3.59e-15 Response to antineoplastic agents; LUSC cis rs2688608 0.592 rs10762563 chr10:75524802 C/A cg23231163 chr10:75533350 FUT11 -0.41 -6.68 -0.34 9.94e-11 Inflammatory bowel disease; LUSC cis rs7937682 0.921 rs11213940 chr11:111433927 C/A cg11344533 chr11:111475393 SIK2 0.44 5.78 0.3 1.68e-8 Primary sclerosing cholangitis; LUSC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg17279839 chr7:150038598 RARRES2 0.56 8.32 0.41 2.28e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs1595825 0.891 rs1016883 chr2:198881668 A/G cg00982548 chr2:198649783 BOLL 0.54 7.02 0.36 1.28e-11 Ulcerative colitis; LUSC cis rs7937682 0.924 rs4630327 chr11:111539327 C/T cg19812747 chr11:111475976 SIK2 0.49 6.94 0.35 2.11e-11 Primary sclerosing cholangitis; LUSC cis rs2011503 0.941 rs4808934 chr19:19370917 C/T cg11244672 chr19:19639970 YJEFN3 -0.52 -6.49 -0.33 3.05e-10 Bipolar disorder; LUSC trans rs6502050 0.799 rs9675196 chr17:80096655 C/T cg07393940 chr7:158741817 NA 0.37 6.78 0.35 5.52e-11 Life satisfaction; LUSC cis rs12458462 0.787 rs56006341 chr18:77439844 G/T cg20476159 chr18:77451067 CTDP1 -0.32 -5.8 -0.3 1.58e-8 Monocyte count; LUSC trans rs225245 0.817 rs2301730 chr17:33998683 A/G cg19694781 chr19:47549865 TMEM160 -0.41 -6.42 -0.33 4.71e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22496380 chr5:211416 CCDC127 -0.81 -8.54 -0.42 4.82e-16 Breast cancer; LUSC cis rs10733682 0.659 rs13287548 chr9:129466456 C/T cg00232160 chr9:129468157 NA 0.43 7.65 0.39 2.22e-13 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11890956 chr21:40555474 PSMG1 1.02 20.66 0.75 1.09e-61 Cognitive function; LUSC trans rs7824557 0.544 rs1865521 chr8:11231249 T/C cg15556689 chr8:8085844 FLJ10661 0.55 8.33 0.41 2.18e-15 Retinal vascular caliber; LUSC cis rs13064411 0.735 rs7636128 chr3:113133701 A/T cg18753928 chr3:113234510 CCDC52 -0.45 -6.86 -0.35 3.43e-11 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg07148914 chr20:33460835 GGT7 -0.56 -8.62 -0.43 2.74e-16 Height; LUSC cis rs72960926 0.744 rs67076726 chr6:74992577 A/G cg03266952 chr6:74778945 NA -0.63 -6.02 -0.31 4.7e-9 Metabolite levels (MHPG); LUSC cis rs1371867 0.846 rs2439460 chr8:101312665 C/T cg00191853 chr8:101177733 SPAG1 -0.39 -6.51 -0.34 2.73e-10 Atrioventricular conduction; LUSC cis rs314370 0.951 rs3757868 chr7:100482720 G/A cg18683606 chr7:100471612 SRRT 0.45 5.96 0.31 6.4e-9 Resting heart rate; LUSC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg05805236 chr11:65401703 PCNXL3 -0.37 -5.65 -0.3 3.5e-8 Breast cancer; LUSC cis rs11997175 0.510 rs34465523 chr8:33796849 C/T ch.8.33884649F chr8:33765107 NA 0.47 6.92 0.35 2.34e-11 Body mass index; LUSC cis rs80130819 0.686 rs78239819 chr12:48412550 C/T cg24011408 chr12:48396354 COL2A1 -0.65 -5.93 -0.31 7.56e-9 Prostate cancer; LUSC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.53 0.62 2.03e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6542838 0.673 rs1949424 chr2:99468341 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.45 6.31 0.33 8.88e-10 Fear of minor pain; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg01171360 chr6:293285 DUSP22 -0.52 -7.9 -0.4 4.07e-14 Menopause (age at onset); LUSC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg03433033 chr1:76189801 ACADM 0.8 12.67 0.57 2.64e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg07701084 chr6:150067640 NUP43 0.57 8.73 0.43 1.28e-16 Lung cancer; LUSC cis rs8114671 0.935 rs945960 chr20:33762854 A/G cg24642439 chr20:33292090 TP53INP2 0.41 5.93 0.31 7.46e-9 Height; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg00166722 chr3:10149974 C3orf24 0.62 8.43 0.42 1.06e-15 Alzheimer's disease; LUSC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg24209194 chr3:40518798 ZNF619 0.48 6.45 0.33 3.91e-10 Renal cell carcinoma; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg10143842 chr3:88198517 C3orf38 0.45 6.39 0.33 5.63e-10 Mosquito bite size; LUSC cis rs11098499 0.580 rs12509234 chr4:120319434 T/C cg24375607 chr4:120327624 NA 0.78 11.51 0.53 4.8e-26 Corneal astigmatism; LUSC trans rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.61 -9.53 -0.46 3.42e-19 Migraine; LUSC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg04414720 chr1:150670196 GOLPH3L 0.53 8.5 0.42 6.19e-16 Tonsillectomy; LUSC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg22800045 chr5:56110881 MAP3K1 0.79 10.51 0.5 1.59e-22 Initial pursuit acceleration; LUSC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg11764359 chr7:65958608 NA 0.68 9.86 0.47 2.69e-20 Aortic root size; LUSC trans rs6981523 0.553 rs11783890 chr8:11056388 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.34 -0.33 7.6e-10 Neuroticism; LUSC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg07701084 chr6:150067640 NUP43 0.57 8.77 0.43 9.32e-17 Lung cancer; LUSC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg11632617 chr15:75315747 PPCDC 0.55 7.07 0.36 9.21e-12 Blood trace element (Zn levels); LUSC cis rs568617 1.000 rs694994 chr11:65653309 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.49 5.82 0.3 1.41e-8 Crohn's disease; LUSC cis rs11958404 0.932 rs72816564 chr5:157427484 T/C cg05962755 chr5:157440814 NA 0.55 6.44 0.33 4.11e-10 IgG glycosylation; LUSC cis rs983392 0.709 rs11603507 chr11:59982470 T/A cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.1e-9 Alzheimer's disease (late onset); LUSC cis rs10492096 0.947 rs10774435 chr12:6616120 G/T cg13857086 chr12:6580257 VAMP1 0.6 7.26 0.37 2.77e-12 Hip geometry; LUSC cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC cis rs1003719 0.679 rs2835674 chr21:38581522 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.2 -0.49 1.91e-21 Eye color traits; LUSC cis rs2067615 0.524 rs10778498 chr12:107063340 C/A cg15890332 chr12:107067104 RFX4 0.35 6.17 0.32 1.98e-9 Heart rate; LUSC cis rs3862030 0.720 rs7081110 chr10:104231651 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.86 -0.44 4.93e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs10193935 0.901 rs10169971 chr2:42602189 G/A cg27598129 chr2:42591480 NA -0.65 -8.37 -0.42 1.59e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9837602 1.000 rs9837602 chr3:99824685 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.24 0.32 1.32e-9 Breast cancer; LUSC cis rs13067593 1.000 rs66506558 chr3:188580731 G/A cg17809494 chr3:188572244 LPP 0.45 6.25 0.32 1.25e-9 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs12712073 0.512 rs6710355 chr2:100699994 T/C cg07810366 chr2:100720526 AFF3 -0.4 -6.29 -0.33 1.02e-9 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.1 -0.36 7.78e-12 Major depressive disorder; LUSC trans rs1422110 0.681 rs35625401 chr5:85465408 G/A cg07913362 chr3:180546450 NA 0.35 6.1 0.32 3.01e-9 Attention function in attention deficit hyperactive disorder; LUSC cis rs4808199 0.895 rs8105094 chr19:19374061 C/T cg03709012 chr19:19516395 GATAD2A 0.94 10.71 0.51 3.28e-23 Nonalcoholic fatty liver disease; LUSC cis rs73198271 0.740 rs10092720 chr8:8649117 A/C cg15556689 chr8:8085844 FLJ10661 -0.45 -6.06 -0.31 3.62e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg16405210 chr4:1374714 KIAA1530 -0.52 -7.72 -0.39 1.38e-13 Obesity-related traits; LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.93 0.51 5.58e-24 Menopause (age at onset); LUSC cis rs8040855 0.825 rs4843021 chr15:85694548 A/G cg04831495 chr15:85060580 GOLGA6L5 0.42 6.13 0.32 2.46e-9 Bulimia nervosa; LUSC cis rs12541635 0.966 rs62525736 chr8:107000638 G/C cg10147462 chr8:107024639 NA 0.55 9.62 0.47 1.75e-19 Age of smoking initiation; LUSC cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg04455712 chr21:45112962 RRP1B -0.46 -8.39 -0.42 1.41e-15 Mean corpuscular volume; LUSC cis rs727505 1.000 rs67084428 chr7:124499388 G/T cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs2294693 0.786 rs12055704 chr6:40988504 C/T cg14769373 chr6:40998127 UNC5CL -0.58 -7.37 -0.37 1.36e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs501916 0.605 rs11070612 chr15:48073174 C/G cg16110827 chr15:48056943 SEMA6D -0.37 -5.85 -0.3 1.18e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg06675538 chr2:114033490 PAX8;LOC440839 -0.33 -5.88 -0.31 9.98e-9 Lymphocyte counts; LUSC cis rs72772090 0.539 rs114006288 chr5:96118004 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.58 -0.34 1.83e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 9.44 0.46 6.69e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4718428 0.705 rs13220977 chr7:66337648 A/T cg18252515 chr7:66147081 NA 0.57 7.86 0.4 5.29e-14 Corneal structure; LUSC cis rs35264875 0.851 rs72930611 chr11:68863659 G/T cg02660097 chr11:68866761 NA 0.44 6.2 0.32 1.66e-9 Blond vs. brown hair color; LUSC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.84 -12.28 -0.56 7.33e-29 Multiple sclerosis; LUSC cis rs78456975 1.000 rs11903168 chr2:1560497 C/G cg01028140 chr2:1542097 TPO -0.6 -8.23 -0.41 4.3e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs10489525 0.517 rs7526694 chr1:115617135 C/T cg01522456 chr1:115632236 TSPAN2 0.41 5.85 0.3 1.17e-8 Autism; LUSC cis rs1577917 0.958 rs12202188 chr6:86562700 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs3092073 0.617 rs56324610 chr20:44564030 G/C cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.36 -5.68 -0.3 2.91e-8 Intelligence (multi-trait analysis); LUSC cis rs9527 0.622 rs12779263 chr10:104886533 G/T cg05855489 chr10:104503620 C10orf26 0.57 8.83 0.44 5.91e-17 Arsenic metabolism; LUSC cis rs11229555 0.609 rs4519113 chr11:58216825 T/C cg15696309 chr11:58395628 NA -0.65 -7.92 -0.4 3.67e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg21466736 chr12:48725269 NA -0.33 -5.75 -0.3 2.06e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs4332037 0.539 rs55790766 chr7:2021248 C/T cg25206134 chr2:45395956 NA 0.59 6.73 0.35 7.35e-11 Bipolar disorder; LUSC cis rs12594515 1.000 rs11855509 chr15:45995474 C/T cg19682013 chr15:45996608 NA 0.39 5.8 0.3 1.51e-8 Waist circumference;Weight; LUSC cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs7267979 0.844 rs4423675 chr20:25402778 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -16.35 -0.67 1.41e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs983392 0.792 rs525794 chr11:59903287 A/G cg24026212 chr11:59952134 MS4A6A -0.31 -5.66 -0.3 3.18e-8 Alzheimer's disease (late onset); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg13390975 chr5:34915890 BRIX1;RAD1 0.39 6.6 0.34 1.58e-10 Triglycerides; LUSC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs12286929 0.736 rs11215397 chr11:115044076 G/A cg04055981 chr11:115044050 NA 0.45 8.29 0.41 2.85e-15 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs477692 1.000 rs565974 chr10:131423274 C/T cg26102564 chr10:131424627 MGMT 0.39 6.16 0.32 2.05e-9 Response to temozolomide; LUSC cis rs2354432 0.607 rs66486822 chr1:146802653 T/A cg25205988 chr1:146714368 CHD1L -1.03 -9.27 -0.45 2.31e-18 Mitochondrial DNA levels; LUSC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg15017067 chr4:17643749 FAM184B 0.36 5.9 0.31 8.95e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7804356 0.953 rs3801829 chr7:26854996 G/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs2710642 0.779 rs360807 chr2:62926859 C/T cg17519650 chr2:63277830 OTX1 -0.53 -7.44 -0.38 8.4e-13 LDL cholesterol levels;LDL cholesterol; LUSC cis rs79387448 0.745 rs1989399 chr2:103166742 G/A cg09003973 chr2:102972529 NA 0.89 8.62 0.43 2.69e-16 Gut microbiota (bacterial taxa); LUSC trans rs7178375 0.941 rs35497908 chr15:31224071 C/T cg04373760 chr16:53404718 NA 0.63 8.78 0.43 8.35e-17 Hypertriglyceridemia; LUSC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg11764359 chr7:65958608 NA 0.8 13.27 0.59 1.43e-32 Aortic root size; LUSC cis rs1030877 1.000 rs2576743 chr2:105901337 C/T cg02079111 chr2:105885981 TGFBRAP1 0.73 13.59 0.6 8.93e-34 Obesity-related traits; LUSC cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg00530320 chr1:46809349 NSUN4 0.55 8.53 0.42 5.28e-16 Menopause (age at onset); LUSC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg23283495 chr1:209979779 IRF6 0.64 7.62 0.38 2.72e-13 Coronary artery disease; LUSC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg21435336 chr19:17392852 ANKLE1 -0.47 -6.33 -0.33 7.95e-10 Systemic lupus erythematosus; LUSC cis rs12701220 0.894 rs10263252 chr7:1049949 G/A cg00990874 chr7:1149470 C7orf50 -0.51 -6.46 -0.33 3.74e-10 Bronchopulmonary dysplasia; LUSC cis rs7000551 0.725 rs2461489 chr8:22370253 G/A cg12081754 chr8:22256438 SLC39A14 0.42 6.26 0.32 1.15e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -10.42 -0.5 3.25e-22 Mean corpuscular volume; LUSC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg25258033 chr6:167368657 RNASET2 -0.47 -7.87 -0.4 5.12e-14 Crohn's disease; LUSC cis rs66887589 0.592 rs2175383 chr4:120215836 C/A cg13609457 chr4:120235615 NA 0.39 6.06 0.31 3.74e-9 Diastolic blood pressure; LUSC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg05855489 chr10:104503620 C10orf26 -0.7 -10.37 -0.49 5.1e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.13 0.45 6.62e-18 Height; LUSC cis rs3820928 1.000 rs10193404 chr2:227777757 A/G cg11843606 chr2:227700838 RHBDD1 -0.55 -8.16 -0.41 6.77e-15 Pulmonary function; LUSC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg18230493 chr5:56204884 C5orf35 0.58 9.09 0.45 9.21e-18 Coronary artery disease; LUSC cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg05707623 chr12:122985044 ZCCHC8 -0.66 -8.47 -0.42 7.97e-16 Body mass index; LUSC cis rs713587 0.776 rs1172294 chr2:25169200 A/G cg01884057 chr2:25150051 NA 0.39 8.68 0.43 1.74e-16 Body mass index in non-asthmatics; LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.67e-9 Monocyte count; LUSC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -6.25 -0.32 1.22e-9 Schizophrenia; LUSC cis rs12122100 0.955 rs12142005 chr1:146506691 T/C cg03526459 chr1:146549940 NA -0.42 -6.75 -0.35 6.54e-11 HIV-1 control; LUSC cis rs9467773 0.620 rs9461276 chr6:26595168 T/C cg05738196 chr6:26577821 NA 0.8 15.3 0.64 2.07e-40 Intelligence (multi-trait analysis); LUSC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -9.92 -0.48 1.68e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs2742417 0.603 rs2064062 chr3:45761115 G/C cg04837898 chr3:45731254 SACM1L -0.44 -7.19 -0.37 4.38e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.9 -0.31 9.06e-9 Reticulocyte fraction of red cells; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21224049 chr4:668623 ATP5I 0.5 8.2 0.41 5.06e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11890956 chr21:40555474 PSMG1 -0.74 -11.37 -0.53 1.47e-25 Menarche (age at onset); LUSC cis rs612683 0.894 rs10875290 chr1:100853755 G/T cg06223162 chr1:101003688 GPR88 0.37 6.81 0.35 4.45e-11 Breast cancer; LUSC cis rs2898290 0.622 rs978802 chr8:11343278 A/T cg21775007 chr8:11205619 TDH -0.5 -7.55 -0.38 4.18e-13 Systolic blood pressure; LUSC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC trans rs7824557 0.628 rs7820301 chr8:11228672 G/A cg15556689 chr8:8085844 FLJ10661 0.47 7.07 0.36 9.15e-12 Retinal vascular caliber; LUSC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg11632617 chr15:75315747 PPCDC -0.51 -6.69 -0.34 9.31e-11 Blood trace element (Zn levels); LUSC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs9649213 0.614 rs3801258 chr7:97988428 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.71 -10.0 -0.48 9.37e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs12422267 0.536 rs12303540 chr12:132609679 A/G cg26561844 chr12:132562101 EP400 0.55 5.83 0.3 1.31e-8 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg16482183 chr6:26056742 HIST1H1C -0.63 -7.82 -0.39 6.96e-14 Iron status biomarkers; LUSC cis rs734999 0.588 rs60520190 chr1:2533706 G/A cg18854424 chr1:2615690 NA 0.49 9.91 0.48 1.84e-20 Ulcerative colitis; LUSC cis rs7608623 0.773 rs12469552 chr2:23923762 A/G cg08917208 chr2:24149416 ATAD2B -0.43 -5.88 -0.31 1e-8 Obesity-related traits; LUSC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg15448220 chr1:150897856 SETDB1 0.39 5.74 0.3 2.18e-8 Tonsillectomy; LUSC trans rs8073060 0.518 rs225285 chr17:33931084 G/C cg19694781 chr19:47549865 TMEM160 -0.82 -12.84 -0.57 6.07e-31 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC cis rs4474465 1.000 rs7950865 chr11:78157401 A/G cg27205649 chr11:78285834 NARS2 -0.52 -6.13 -0.32 2.46e-9 Alzheimer's disease (survival time); LUSC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg06740227 chr12:86229804 RASSF9 0.45 6.98 0.36 1.58e-11 Major depressive disorder; LUSC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg18225595 chr11:63971243 STIP1 0.44 7.15 0.36 5.38e-12 Platelet count; LUSC cis rs9660992 0.573 rs1172147 chr1:205225457 G/A cg00857998 chr1:205179979 DSTYK 0.62 9.4 0.46 8.87e-19 Mean corpuscular volume;Mean platelet volume; LUSC trans rs2302464 1.000 rs73123625 chr4:15729173 A/T cg17675199 chr6:35436792 RPL10A -0.88 -6.15 -0.32 2.26e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs926938 0.527 rs2335954 chr1:115534151 C/T cg12756093 chr1:115239321 AMPD1 -0.48 -7.34 -0.37 1.59e-12 Autism; LUSC trans rs61931739 0.517 rs2101396 chr12:34048927 T/A cg13010199 chr12:38710504 ALG10B 0.52 7.91 0.4 3.72e-14 Morning vs. evening chronotype; LUSC cis rs9399135 0.967 rs11756988 chr6:135347595 A/G cg22676075 chr6:135203613 NA 0.47 7.4 0.38 1.12e-12 Red blood cell count; LUSC cis rs503734 0.643 rs2317749 chr3:101121980 C/T cg20575173 chr3:101228308 SENP7 0.32 5.71 0.3 2.47e-8 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg17442961 chr17:78635428 RPTOR -0.39 -6.59 -0.34 1.72e-10 N-glycan levels; LUSC cis rs13385 0.769 rs59453051 chr5:139558212 T/G cg26211634 chr5:139558579 C5orf32 0.45 6.54 0.34 2.25e-10 Atrial fibrillation; LUSC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.65 0.47 1.38e-19 Bipolar disorder; LUSC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg00343986 chr7:65444356 GUSB 0.47 7.12 0.36 6.76e-12 Aortic root size; LUSC cis rs1215050 0.791 rs165239 chr4:98682549 C/T cg05340658 chr4:99064831 C4orf37 0.46 7.28 0.37 2.39e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg04267008 chr7:1944627 MAD1L1 -0.56 -8.48 -0.42 7.37e-16 Bipolar disorder and schizophrenia; LUSC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg26818010 chr10:134567672 INPP5A -0.86 -11.07 -0.52 1.83e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B 0.33 6.0 0.31 5.12e-9 IgG glycosylation; LUSC cis rs2486288 0.656 rs2461705 chr15:45570241 A/G cg26924012 chr15:45694286 SPATA5L1 -0.75 -11.09 -0.52 1.57e-24 Glomerular filtration rate; LUSC cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg08999081 chr20:33150536 PIGU 0.53 10.6 0.5 7.79e-23 Coronary artery disease; LUSC cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg05294307 chr14:35346193 BAZ1A -0.6 -6.49 -0.33 3.14e-10 Psoriasis; LUSC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg11812906 chr14:75593930 NEK9 0.54 8.75 0.43 1.08e-16 Coronary artery disease; LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg04267008 chr7:1944627 MAD1L1 -0.57 -8.64 -0.43 2.29e-16 Bipolar disorder and schizophrenia; LUSC cis rs6674970 0.966 rs4512652 chr1:151115690 G/C cg03258749 chr1:151040405 MLLT11 -0.42 -6.36 -0.33 6.58e-10 Childhood ear infection; LUSC cis rs12519773 0.555 rs2009416 chr5:92415111 C/T cg18783429 chr5:92414398 NA 0.35 7.78 0.39 9.11e-14 Migraine; LUSC cis rs9300255 0.537 rs1716182 chr12:123686127 A/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.89 -0.31 9.5e-9 Neutrophil percentage of white cells; LUSC cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.91e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7939886 0.920 rs11227729 chr11:56039901 G/A cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC trans rs7769051 0.711 rs7770081 chr6:133089569 G/T cg27275811 chr11:74457193 NA -0.6 -6.02 -0.31 4.63e-9 Type 2 diabetes nephropathy; LUSC cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg03146154 chr1:46216737 IPP 0.51 7.55 0.38 4.21e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg10253484 chr15:75165896 SCAMP2 -0.42 -6.06 -0.31 3.67e-9 Caffeine consumption; LUSC cis rs977987 0.843 rs4888427 chr16:75478447 A/G cg03315344 chr16:75512273 CHST6 0.54 10.61 0.5 7.6e-23 Dupuytren's disease; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg00166722 chr3:10149974 C3orf24 0.62 8.72 0.43 1.32e-16 Alzheimer's disease; LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg02475777 chr4:1388615 CRIPAK 0.62 9.3 0.45 1.88e-18 Longevity; LUSC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg01191920 chr7:158217561 PTPRN2 0.57 11.98 0.55 9.15e-28 Obesity-related traits; LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.55 -7.92 -0.4 3.49e-14 Gut microbiome composition (summer); LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg24813613 chr7:1882135 MAD1L1 -0.43 -7.3 -0.37 2.18e-12 Bipolar disorder and schizophrenia; LUSC cis rs17632159 0.619 rs13160226 chr5:72434224 A/G cg01170694 chr5:72431891 NA -0.29 -5.88 -0.31 9.71e-9 Urate levels; LUSC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -8.71 -0.43 1.45e-16 Hemoglobin concentration; LUSC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg21984481 chr17:79567631 NPLOC4 -0.67 -14.02 -0.61 1.9e-35 Eye color traits; LUSC cis rs4148883 0.645 rs1154404 chr4:100009004 A/T cg12011299 chr4:100065546 ADH4 0.49 7.96 0.4 2.68e-14 Alcohol dependence; LUSC cis rs6700896 0.500 rs7540268 chr1:66085236 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg22968622 chr17:43663579 NA 0.8 12.37 0.56 3.3600000000000003e-29 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs4343996 1.000 rs12700789 chr7:3358276 T/C cg21248987 chr7:3385318 SDK1 -0.38 -6.45 -0.33 3.91e-10 Motion sickness; LUSC cis rs782590 0.967 rs782588 chr2:55841640 T/C cg18811423 chr2:55921094 PNPT1 0.84 14.6 0.62 1.06e-37 Metabolic syndrome; LUSC cis rs7122539 0.646 rs594313 chr11:66608991 A/G cg24851651 chr11:66362959 CCS 0.54 8.96 0.44 2.31e-17 HIV-1 susceptibility; LUSC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg26677194 chr12:130822605 PIWIL1 0.59 8.79 0.43 7.9e-17 Menopause (age at onset); LUSC cis rs9300255 0.537 rs10772993 chr12:123644714 A/G cg00376283 chr12:123451042 ABCB9 0.65 7.51 0.38 5.51e-13 Neutrophil percentage of white cells; LUSC cis rs5769707 0.749 rs8137251 chr22:50036669 G/A cg20744362 chr22:50050164 C22orf34 0.39 7.66 0.39 2.01e-13 Monocyte count;Monocyte percentage of white cells; LUSC trans rs3903072 0.528 rs7928652 chr11:65580228 A/C cg17712092 chr4:129076599 LARP1B 0.54 7.13 0.36 6.4e-12 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19760225 chr17:27920361 ANKRD13B 0.49 6.7 0.34 8.81e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7746199 0.736 rs13210634 chr6:27646492 A/G cg01620082 chr3:125678407 NA -0.77 -6.9 -0.35 2.57e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg23711669 chr6:146136114 FBXO30 0.77 13.91 0.61 5.36e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs10840133 1 rs10840133 chr11:8846369 G/A cg12365402 chr11:9010492 NRIP3 0.36 6.2 0.32 1.66e-9 Reticulocyte fraction of red cells; LUSC cis rs3099143 1.000 rs3099142 chr15:77104909 C/T cg21673338 chr15:77095150 SCAPER -0.78 -7.47 -0.38 7.09e-13 Recalcitrant atopic dermatitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20096481 chr8:87355098 WWP1 0.44 6.2 0.32 1.67e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC trans rs7824557 0.701 rs4568582 chr8:11160495 A/T cg15556689 chr8:8085844 FLJ10661 0.55 8.41 0.42 1.22e-15 Retinal vascular caliber; LUSC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.64 -13.48 -0.59 2.22e-33 Monocyte percentage of white cells; LUSC cis rs7584330 0.554 rs13392410 chr2:238430273 G/A cg16989719 chr2:238392110 NA -0.41 -5.75 -0.3 2.01e-8 Prostate cancer; LUSC cis rs780094 0.500 rs4665991 chr2:27766284 G/A cg27432699 chr2:27873401 GPN1 0.4 5.65 0.3 3.43e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.35 5.66 0.3 3.28e-8 Cystic fibrosis severity; LUSC cis rs12704876 0.509 rs6966856 chr7:96367627 G/A cg03808172 chr7:96339361 SHFM1 0.51 7.73 0.39 1.3e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18943969 chr1:117209947 IGSF3 0.48 6.5 0.34 2.9e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg07636037 chr3:49044803 WDR6 0.98 15.22 0.64 4.11e-40 Parkinson's disease; LUSC cis rs4343996 0.807 rs6964838 chr7:3509969 A/G cg21248987 chr7:3385318 SDK1 -0.35 -5.71 -0.3 2.48e-8 Motion sickness; LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg08888203 chr3:10149979 C3orf24 0.62 8.67 0.43 1.92e-16 Alzheimer's disease; LUSC trans rs35110281 0.782 rs2329442 chr21:45041790 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.54 0.53 3.8e-26 Mean corpuscular volume; LUSC cis rs12681288 0.550 rs4410933 chr8:959581 A/G cg04851639 chr8:1020857 NA -0.35 -7.05 -0.36 1.01e-11 Schizophrenia; LUSC cis rs9650315 0.733 rs7838625 chr8:57187365 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.41 0.33 4.87e-10 Height; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg11494091 chr17:61959527 GH2 0.63 13.45 0.59 3e-33 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg00945038 chr17:61921165 SMARCD2 0.53 9.27 0.45 2.34e-18 Prudent dietary pattern; LUSC cis rs425277 1.000 rs436045 chr1:2071556 A/G cg03732007 chr1:2071316 PRKCZ -0.47 -7.45 -0.38 8.02e-13 Height; LUSC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg22920501 chr2:26401640 FAM59B -0.73 -10.4 -0.49 3.91e-22 Gut microbiome composition (summer); LUSC trans rs2243480 1.000 rs1723269 chr7:65472786 C/G cg10756647 chr7:56101905 PSPH 0.85 8.27 0.41 3.11e-15 Diabetic kidney disease; LUSC cis rs12421382 0.576 rs116158609 chr11:109389358 T/A cg11473876 chr11:109292803 C11orf87 0.35 5.97 0.31 5.95e-9 Schizophrenia; LUSC cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.45 0.33 3.98e-10 Lung cancer; LUSC trans rs57221529 0.766 rs72703075 chr5:592819 C/T cg25482853 chr8:67687455 SGK3 1.19 16.14 0.66 1.02e-43 Lung disease severity in cystic fibrosis; LUSC cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg06552810 chr11:31128660 NA -0.4 -7.13 -0.36 6.38e-12 Red blood cell count; LUSC cis rs7103648 0.864 rs12801188 chr11:47388214 G/A cg20307385 chr11:47447363 PSMC3 0.9 15.64 0.65 9.49e-42 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs9303280 0.934 rs56380902 chr17:38066372 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.92 0.31 8.05e-9 Self-reported allergy; LUSC trans rs61931739 0.500 rs11053269 chr12:34545307 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs9303401 0.659 rs7224276 chr17:56897827 C/T cg25039879 chr17:56429692 SUPT4H1 0.67 9.01 0.44 1.65e-17 Cognitive test performance; LUSC cis rs2197308 0.623 rs1672426 chr12:38118671 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.2 -0.49 1.87e-21 Morning vs. evening chronotype; LUSC cis rs3820068 0.626 rs61103742 chr1:15909153 A/C cg17385448 chr1:15911702 AGMAT 0.37 5.98 0.31 5.64e-9 Systolic blood pressure; LUSC cis rs17253792 0.822 rs78988988 chr14:56152404 G/A cg01858014 chr14:56050164 KTN1 -0.82 -6.77 -0.35 5.9e-11 Putamen volume; LUSC cis rs9611519 0.964 rs2092563 chr22:41592677 G/A cg03806693 chr22:41940476 POLR3H -0.55 -7.52 -0.38 5.04e-13 Neuroticism; LUSC cis rs4595586 0.545 rs12826080 chr12:39387772 A/G cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs9549260 0.569 rs73174811 chr13:41315998 T/G cg21288729 chr13:41239152 FOXO1 0.53 5.79 0.3 1.6e-8 Red blood cell count; LUSC cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -8.04 -0.4 1.62e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg02711726 chr17:80685570 FN3KRP -0.43 -6.49 -0.33 3.14e-10 Glycated hemoglobin levels; LUSC cis rs3736594 0.513 rs60854669 chr2:27786929 T/C cg27432699 chr2:27873401 GPN1 0.66 8.83 0.44 5.93e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2120019 0.935 rs34835684 chr15:75331805 T/G cg17294928 chr15:75287854 SCAMP5 -0.92 -13.07 -0.58 8.12e-32 Blood trace element (Zn levels); LUSC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg11764359 chr7:65958608 NA -0.69 -10.53 -0.5 1.42e-22 Aortic root size; LUSC cis rs8017423 0.967 rs4904657 chr14:90721600 A/G cg14092571 chr14:90743983 NA -0.35 -5.83 -0.3 1.29e-8 Mortality in heart failure; LUSC cis rs45535039 1.000 rs1893034 chr11:119089390 C/G cg16724696 chr11:118992527 HINFP 0.48 5.79 0.3 1.66e-8 Plateletcrit; LUSC cis rs7903847 0.619 rs76094900 chr10:99158164 G/A cg08345082 chr10:99160200 RRP12 -0.36 -7.07 -0.36 9.25e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs11864453 0.826 rs12325142 chr16:72138112 G/T cg23815491 chr16:72088622 HP 0.34 5.97 0.31 6.12e-9 Fibrinogen levels; LUSC cis rs4499344 0.730 rs392332 chr19:33105743 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.87 13.17 0.58 3.36e-32 Mean platelet volume; LUSC trans rs4295623 0.789 rs12541318 chr8:11594970 G/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.62 -0.38 2.61e-13 Morning vs. evening chronotype; LUSC cis rs34779708 0.898 rs4934695 chr10:35280605 C/T cg04310649 chr10:35416472 CREM -0.44 -6.58 -0.34 1.85e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg08645402 chr16:4508243 NA 0.48 7.63 0.39 2.4e-13 Schizophrenia; LUSC cis rs9527 0.830 rs11191442 chr10:104643596 T/A cg23093090 chr10:104574429 C10orf26 -0.38 -6.55 -0.34 2.22e-10 Arsenic metabolism; LUSC cis rs7582180 0.700 rs4640404 chr2:100980523 C/T cg08017756 chr2:100939284 LONRF2 0.42 7.68 0.39 1.82e-13 Intelligence (multi-trait analysis); LUSC cis rs73198271 0.694 rs73201840 chr8:8647067 G/T cg01851573 chr8:8652454 MFHAS1 0.52 8.12 0.41 9.04e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg18196295 chr10:418757 DIP2C 0.51 8.41 0.42 1.17e-15 Psychosis in Alzheimer's disease; LUSC cis rs7824557 0.510 rs2736297 chr8:11234885 C/G cg21775007 chr8:11205619 TDH -0.65 -10.34 -0.49 6.55e-22 Retinal vascular caliber; LUSC cis rs6066835 1.000 rs4516495 chr20:47316482 A/G cg18078177 chr20:47281410 PREX1 0.71 6.5 0.34 2.92e-10 Multiple myeloma; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg07754938 chr3:48885314 PRKAR2A 0.46 6.23 0.32 1.37e-9 Response to Homoharringtonine (cytotoxicity); LUSC trans rs2243480 1.000 rs6460274 chr7:65628484 T/A cg10756647 chr7:56101905 PSPH -0.84 -8.39 -0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg00409905 chr10:38381863 ZNF37A -0.37 -6.37 -0.33 6.35e-10 Extrinsic epigenetic age acceleration; LUSC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg05855489 chr10:104503620 C10orf26 -0.67 -9.67 -0.47 1.2e-19 Allergic disease (asthma, hay fever or eczema); LUSC cis rs79149102 0.579 rs12593476 chr15:75282092 A/C cg09165964 chr15:75287851 SCAMP5 -0.88 -7.68 -0.39 1.79e-13 Lung cancer; LUSC cis rs7666738 0.515 rs13434650 chr4:98889886 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.87 0.44 4.39e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs8017423 0.967 rs8015510 chr14:90729984 C/T cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs7572644 0.699 rs7577342 chr2:28205581 A/G cg27432699 chr2:27873401 GPN1 0.51 7.09 0.36 8.19e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg07828340 chr4:882639 GAK 1.0 10.76 0.51 2.16e-23 Intelligence (multi-trait analysis); LUSC cis rs2880765 0.631 rs55767890 chr15:86004142 C/G cg10818794 chr15:86012489 AKAP13 -0.43 -6.81 -0.35 4.66e-11 Coronary artery disease; LUSC cis rs17401966 1.000 rs12402052 chr1:10318652 C/G cg19773385 chr1:10388646 KIF1B -0.53 -8.3 -0.41 2.57e-15 Hepatocellular carcinoma; LUSC cis rs4805272 0.512 rs12373558 chr19:29337692 A/G cg04546413 chr19:29218101 NA 0.57 7.29 0.37 2.22e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs1358748 0.522 rs6588237 chr1:67558739 C/T cg02640540 chr1:67518911 SLC35D1 0.64 6.3 0.33 9.51e-10 Tuberculosis; LUSC cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg08999081 chr20:33150536 PIGU 0.52 10.31 0.49 7.91e-22 Glomerular filtration rate (creatinine); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12821546 chr22:41601310 L3MBTL2 0.45 6.31 0.33 8.63e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg05283184 chr6:79620031 NA -0.57 -12.07 -0.55 4.49e-28 Intelligence (multi-trait analysis); LUSC cis rs6754311 0.552 rs1030765 chr2:136553188 A/T cg25344623 chr2:136566232 LCT 0.37 5.65 0.3 3.47e-8 Mosquito bite size; LUSC cis rs2030746 0.521 rs2311598 chr2:121331102 A/G cg03661458 chr2:121334411 NA -0.33 -6.4 -0.33 5.11e-10 LDL cholesterol;Total cholesterol levels;LDL cholesterol levels; LUSC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg03709012 chr19:19516395 GATAD2A 0.87 14.83 0.63 1.38e-38 Tonsillectomy; LUSC cis rs12681287 0.547 rs7837569 chr8:87507366 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg22963979 chr7:1858916 MAD1L1 -0.56 -8.58 -0.42 3.65e-16 Bipolar disorder and schizophrenia; LUSC cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg24011408 chr12:48396354 COL2A1 -0.4 -5.77 -0.3 1.77e-8 Bipolar disorder and schizophrenia; LUSC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg13393036 chr8:95962371 TP53INP1 -0.48 -10.43 -0.5 3.08e-22 Type 2 diabetes; LUSC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg17330251 chr7:94953956 PON1 -0.37 -5.85 -0.31 1.15e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10426930 0.700 rs8106479 chr19:5003940 G/C cg25246084 chr19:4971487 KDM4B -0.34 -6.17 -0.32 1.99e-9 Monocyte percentage of white cells; LUSC cis rs600231 0.708 rs602838 chr11:65253247 T/G cg17120908 chr11:65337727 SSSCA1 -0.54 -9.41 -0.46 8.11e-19 Bone mineral density; LUSC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.96 -0.36 1.83e-11 Total body bone mineral density; LUSC cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg26384229 chr12:38710491 ALG10B 0.93 17.54 0.69 2.66e-49 Heart rate; LUSC cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC trans rs9944275 0.518 rs12903849 chr15:97189925 A/G cg18834029 chr10:103349097 POLL;RP11-529I10.4 -0.6 -5.97 -0.31 6.23e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); LUSC cis rs367943 0.712 rs9326889 chr5:112731438 A/G cg12552261 chr5:112820674 MCC 0.36 5.85 0.3 1.17e-8 Type 2 diabetes; LUSC cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg00631329 chr6:26305371 NA -0.45 -8.86 -0.44 4.68e-17 Educational attainment; LUSC cis rs8179 0.514 rs10269774 chr7:92253972 A/G cg15732164 chr7:92237376 CDK6 0.38 5.96 0.31 6.55e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.21 -0.37 3.86e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg01503450 chr10:980765 NA -0.39 -5.77 -0.3 1.82e-8 Eosinophil percentage of granulocytes; LUSC cis rs7267979 0.932 rs6132848 chr20:25561645 C/T cg03522245 chr20:25566470 NINL 0.36 5.86 0.31 1.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9733 0.540 rs4971041 chr1:150537357 C/T cg04414720 chr1:150670196 GOLPH3L -0.43 -6.47 -0.33 3.46e-10 Tonsillectomy; LUSC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg16434002 chr17:42200994 HDAC5 0.45 6.01 0.31 4.79e-9 Total body bone mineral density; LUSC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg22535103 chr8:58192502 C8orf71 -0.85 -8.4 -0.42 1.28e-15 Developmental language disorder (linguistic errors); LUSC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.59 7.93 0.4 3.38e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg16680214 chr1:154839983 KCNN3 -0.56 -10.94 -0.51 5.23e-24 Prostate cancer; LUSC cis rs934734 0.563 rs11695373 chr2:65581200 A/G cg08085232 chr2:65598271 SPRED2 -0.43 -6.75 -0.35 6.74e-11 Rheumatoid arthritis; LUSC trans rs7829975 0.626 rs332040 chr8:8730488 G/A cg27411982 chr8:10470053 RP1L1 0.49 7.67 0.39 1.93e-13 Mood instability; LUSC cis rs1348850 0.526 rs6723014 chr2:178410586 G/A cg22681709 chr2:178499509 PDE11A -0.44 -6.5 -0.34 2.86e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9341808 0.519 rs660888 chr6:80983212 A/T cg08355045 chr6:80787529 NA 0.41 7.05 0.36 1.03e-11 Sitting height ratio; LUSC cis rs243505 0.861 rs243531 chr7:148412513 A/G cg09806900 chr7:148480153 CUL1 -0.46 -6.61 -0.34 1.51e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10788264 0.569 rs10749454 chr10:124029654 C/T cg09507567 chr10:124027408 NA 0.56 10.11 0.48 3.83e-21 Total body bone mineral density; LUSC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Tonsillectomy; LUSC cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.49 7.86 0.39 5.49e-14 IgG glycosylation; LUSC trans rs1493916 0.837 rs1493908 chr18:31411700 G/A cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs1577917 0.883 rs1337854 chr6:86724015 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.42 6.17 0.32 1.92e-9 Response to antipsychotic treatment; LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg02475777 chr4:1388615 CRIPAK -0.61 -9.05 -0.44 1.22e-17 Longevity; LUSC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg05754148 chr16:3507555 NAT15 -0.69 -8.17 -0.41 6.4e-15 Tuberculosis; LUSC cis rs908922 0.676 rs7530609 chr1:152526812 C/A cg20991723 chr1:152506922 NA 0.49 9.23 0.45 3.09e-18 Hair morphology; LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.47 8.12 0.41 9.28e-15 Electroencephalogram traits; LUSC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg04450456 chr4:17643702 FAM184B 0.38 6.47 0.33 3.5e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7824557 0.583 rs2736292 chr8:11234500 A/T cg08975724 chr8:8085496 FLJ10661 0.44 6.56 0.34 2.01e-10 Retinal vascular caliber; LUSC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg03806693 chr22:41940476 POLR3H 0.99 13.81 0.6 1.28e-34 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7267979 0.966 rs2261784 chr20:25262396 G/C cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.11e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg14784868 chr12:69753453 YEATS4 0.6 8.88 0.44 4.11e-17 Blood protein levels; LUSC trans rs35110281 0.807 rs6518301 chr21:45016818 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.48 0.46 4.93e-19 Mean corpuscular volume; LUSC cis rs12893668 0.543 rs12147645 chr14:104100208 T/A cg04998671 chr14:104000505 TRMT61A -0.4 -5.83 -0.3 1.3e-8 Reticulocyte count; LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.45 7.68 0.39 1.75e-13 Cognitive function; LUSC cis rs897080 0.589 rs1067380 chr2:44646834 A/C cg00619915 chr2:44497795 NA -0.42 -5.94 -0.31 6.97e-9 Height; LUSC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.15 -0.36 5.59e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12545109 0.765 rs1960726 chr8:57411733 T/C cg09654669 chr8:57350985 NA -0.58 -7.84 -0.39 5.98e-14 Obesity-related traits; LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg24846343 chr22:24311635 DDTL 0.62 12.86 0.58 5.02e-31 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg20656751 chr4:2061512 NAT8L -0.38 -6.0 -0.31 5.1e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg26587870 chr6:27730563 NA -0.57 -5.73 -0.3 2.21e-8 Depression; LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg00166722 chr3:10149974 C3orf24 0.54 7.5 0.38 6e-13 Alzheimer's disease; LUSC cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg13319975 chr6:146136371 FBXO30 0.45 6.99 0.36 1.51e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg07636037 chr3:49044803 WDR6 0.8 11.63 0.54 1.79e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg25174290 chr11:3078921 CARS -0.42 -6.3 -0.33 9.19e-10 Calcium levels; LUSC cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.79 -0.43 8.23e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6840360 1.000 rs907237 chr4:152601146 T/G cg22705602 chr4:152727874 NA -0.27 -5.64 -0.3 3.55e-8 Intelligence (multi-trait analysis); LUSC trans rs2228479 0.702 rs12600151 chr16:89831558 C/T cg24644049 chr4:85504048 CDS1 0.88 7.53 0.38 4.81e-13 Skin colour saturation; LUSC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11890956 chr21:40555474 PSMG1 1.03 19.81 0.74 2.52e-58 Cognitive function; LUSC cis rs11608355 0.515 rs2287192 chr12:109931594 C/T cg05360138 chr12:110035743 NA 0.9 11.97 0.55 1.02e-27 Neuroticism; LUSC cis rs3857536 0.776 rs6941904 chr6:66931042 A/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs3818285 0.959 rs492943 chr10:111629030 A/T cg00817464 chr10:111662876 XPNPEP1 0.55 7.0 0.36 1.37e-11 Superior crus of antihelix expression; LUSC cis rs6545883 0.894 rs2694639 chr2:61595291 G/A cg15711740 chr2:61764176 XPO1 0.42 6.33 0.33 7.86e-10 Tuberculosis; LUSC cis rs954108 0.809 rs1792022 chr13:29367967 A/G cg11788234 chr13:29393811 NA -0.38 -6.61 -0.34 1.49e-10 Obesity-related traits; LUSC cis rs7917772 0.582 rs10786696 chr10:104378134 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.08 0.52 1.68e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7681440 0.967 rs920624 chr4:90748195 T/A cg01966878 chr4:90757139 SNCA -0.33 -5.68 -0.3 2.97e-8 Dementia with Lewy bodies; LUSC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 5.65 0.3 3.41e-8 Personality dimensions; LUSC cis rs6665290 0.870 rs17600725 chr1:227204231 A/G cg10327440 chr1:227177885 CDC42BPA -1.22 -38.27 -0.9 3.83e-124 Myeloid white cell count; LUSC cis rs1595825 0.891 rs73054825 chr2:198636355 G/C cg00982548 chr2:198649783 BOLL -0.59 -7.35 -0.37 1.51e-12 Ulcerative colitis; LUSC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg14552801 chr7:65878734 NA 0.39 6.06 0.31 3.67e-9 Aortic root size; LUSC cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg23711669 chr6:146136114 FBXO30 0.83 14.71 0.63 4.06e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs72772090 0.539 rs11747179 chr5:96112969 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.67 -0.34 1.04e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9346649 0.967 rs6915427 chr6:168490000 A/T cg02770688 chr6:168491649 NA 0.4 7.67 0.39 1.96e-13 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg17971929 chr21:40555470 PSMG1 0.78 13.12 0.58 5.26e-32 Cognitive function; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07336999 chr16:89939803 TCF25 -0.41 -6.8 -0.35 4.94e-11 Electrocardiographic conduction measures; LUSC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg00815214 chr21:47717953 NA -0.36 -5.68 -0.3 2.92e-8 Testicular germ cell tumor; LUSC cis rs4601821 0.858 rs7945132 chr11:113262473 A/T cg14159747 chr11:113255604 NA 0.26 6.06 0.31 3.67e-9 Alcoholic chronic pancreatitis; LUSC cis rs9303401 0.659 rs34275691 chr17:56736640 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.55e-35 Cognitive test performance; LUSC cis rs7312933 0.558 rs11181466 chr12:42765181 A/T cg01256987 chr12:42539512 GXYLT1 -0.41 -7.46 -0.38 7.71e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1941023 0.584 rs7935082 chr11:60155000 T/C cg08716584 chr11:60157161 MS4A7 -0.65 -12.41 -0.56 2.42e-29 Congenital heart disease (maternal effect); LUSC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 5.99 0.31 5.32e-9 Mean platelet volume; LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg24101359 chr6:42928495 GNMT 0.41 6.97 0.36 1.72e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg00945038 chr17:61921165 SMARCD2 0.52 9.22 0.45 3.31e-18 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2046867 0.818 rs17010184 chr3:72870242 A/T cg25664220 chr3:72788482 NA 0.69 12.13 0.55 2.72e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11123610 0.520 rs13409381 chr2:3722579 A/G cg19052272 chr2:3704530 ALLC -0.48 -7.97 -0.4 2.59e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1018836 0.505 rs7015030 chr8:91460331 T/C cg16814680 chr8:91681699 NA -0.48 -6.88 -0.35 3.01e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg13628971 chr7:2884303 GNA12 0.47 6.91 0.35 2.48e-11 Height; LUSC cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg08999081 chr20:33150536 PIGU 0.39 6.84 0.35 3.8e-11 Coronary artery disease; LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg07507251 chr3:52567010 NT5DC2 0.34 6.73 0.35 7.51e-11 Bipolar disorder; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg00149659 chr3:10157352 C3orf10 0.91 12.69 0.57 2.26e-30 Alzheimer's disease; LUSC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg03388025 chr16:89894329 SPIRE2 0.33 6.9 0.35 2.54e-11 Vitiligo; LUSC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg06074448 chr4:187884817 NA -0.39 -6.48 -0.33 3.29e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs11039100 0.765 rs1032648 chr11:5782756 A/G cg05234568 chr11:5960015 NA -0.52 -5.76 -0.3 1.9e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs968567 0.559 rs174548 chr11:61571348 C/G cg19610905 chr11:61596333 FADS2 -0.5 -7.49 -0.38 6.38e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.4e-14 Prudent dietary pattern; LUSC cis rs812925 0.571 rs3087898 chr2:61765074 G/A cg15711740 chr2:61764176 XPO1 -0.39 -5.98 -0.31 5.59e-9 Immature fraction of reticulocytes; LUSC cis rs11640436 0.934 rs35478105 chr16:77325325 G/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.37 5.88 0.31 9.85e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg23172400 chr8:95962367 TP53INP1 0.29 5.72 0.3 2.38e-8 Type 2 diabetes; LUSC cis rs2806561 0.929 rs10917357 chr1:23535161 C/T cg19743168 chr1:23544995 NA 0.48 10.4 0.49 3.81e-22 Height; LUSC cis rs525592 1 rs525592 chr11:68195104 C/T cg01657329 chr11:68192670 LRP5 -0.48 -7.42 -0.38 9.69e-13 Bone mineral density; LUSC cis rs981844 0.775 rs55986083 chr4:154765640 A/C cg14289246 chr4:154710475 SFRP2 0.51 6.72 0.35 7.76e-11 Response to statins (LDL cholesterol change); LUSC cis rs4604732 0.631 rs34924545 chr1:247626892 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.43 6.41 0.33 4.93e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs12594515 0.967 rs11856523 chr15:45989495 C/T cg01629716 chr15:45996671 NA 0.39 5.89 0.31 9.31e-9 Waist circumference;Weight; LUSC cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg05340658 chr4:99064831 C4orf37 0.58 7.82 0.39 7.07e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg23601095 chr6:26197514 HIST1H3D 0.7 7.54 0.38 4.55e-13 Gout;Renal underexcretion gout; LUSC cis rs7605827 0.930 rs12692265 chr2:15544998 T/C cg19274914 chr2:15703543 NA 0.46 8.71 0.43 1.38e-16 Educational attainment (years of education); LUSC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.504 rs7771014 chr6:150205446 T/A cg04369109 chr6:150039330 LATS1 -0.4 -5.77 -0.3 1.81e-8 Lung cancer; LUSC cis rs9467773 1.000 rs2224380 chr6:26553943 G/A cg11502198 chr6:26597334 ABT1 0.62 9.85 0.47 2.95e-20 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.954 rs6857105 chr4:120222298 C/G cg09307838 chr4:120376055 NA 0.8 11.6 0.54 2.28e-26 Corneal astigmatism; LUSC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.48 7.11 0.36 7.31e-12 Personality dimensions; LUSC cis rs34330 0.562 rs11055024 chr12:12858969 A/G cg04607235 chr12:12878440 APOLD1 -0.56 -6.38 -0.33 5.81e-10 Systemic lupus erythematosus; LUSC cis rs7786808 0.653 rs7810861 chr7:158212633 G/A cg09998033 chr7:158218633 PTPRN2 -0.38 -5.98 -0.31 5.58e-9 Obesity-related traits; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg10862848 chr6:42927986 GNMT -0.28 -6.68 -0.34 1.01e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7178572 0.889 rs59153558 chr15:77806770 A/G cg22256960 chr15:77711686 NA -0.51 -8.21 -0.41 4.84e-15 Type 2 diabetes; LUSC trans rs6920965 0.561 rs9401851 chr6:126181956 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.42 -6.33 -0.33 8.12e-10 High light scatter reticulocyte count; LUSC cis rs3820928 0.605 rs4675124 chr2:227802354 G/A cg11843606 chr2:227700838 RHBDD1 -0.65 -10.41 -0.49 3.66e-22 Pulmonary function; LUSC cis rs9300255 0.602 rs1716168 chr12:123651966 C/G cg13010344 chr12:123464640 ARL6IP4 0.43 5.82 0.3 1.38e-8 Neutrophil percentage of white cells; LUSC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg24578937 chr1:2090814 PRKCZ -0.42 -9.08 -0.45 9.36e-18 Height; LUSC trans rs984440 0.542 rs1073348 chr8:139082730 T/C cg03334052 chr1:168888044 NA 0.38 6.22 0.32 1.46e-9 Obesity-related traits; LUSC cis rs7766436 0.885 rs3734215 chr6:22571323 T/C cg13666174 chr6:22585274 NA -0.41 -5.66 -0.3 3.35e-8 Coronary artery disease; LUSC cis rs1153858 0.832 rs1145078 chr15:45682277 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.46 0.5 2.52e-22 Homoarginine levels; LUSC cis rs4343996 0.754 rs10807838 chr7:3344401 C/T cg21248987 chr7:3385318 SDK1 -0.38 -6.48 -0.33 3.32e-10 Motion sickness; LUSC cis rs1107366 0.722 rs2364368 chr3:125905080 A/T cg01346077 chr3:125931526 NA 0.33 6.27 0.32 1.15e-9 Metabolite levels; LUSC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg05313129 chr8:58192883 C8orf71 -0.51 -6.42 -0.33 4.67e-10 Developmental language disorder (linguistic errors); LUSC cis rs7584330 0.554 rs114331205 chr2:238432559 A/C cg16989719 chr2:238392110 NA -0.41 -5.77 -0.3 1.85e-8 Prostate cancer; LUSC cis rs6752107 1.000 rs10165561 chr2:234172915 G/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.56 0.53 3.25e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs3847687 1.000 rs34853396 chr12:131519265 G/T cg13586425 chr12:131519906 GPR133 -0.27 -6.24 -0.32 1.36e-9 Longevity; LUSC cis rs921968 0.613 rs2556388 chr2:219541056 T/C cg02176678 chr2:219576539 TTLL4 -0.59 -10.45 -0.5 2.59e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs9611565 0.525 rs1883827 chr22:41703579 A/G cg03806693 chr22:41940476 POLR3H -0.61 -9.01 -0.44 1.62e-17 Vitiligo; LUSC cis rs8180040 0.522 rs749512 chr3:47035900 C/T cg27129171 chr3:47204927 SETD2 -0.65 -9.83 -0.47 3.3e-20 Colorectal cancer; LUSC cis rs2486288 0.656 rs12899058 chr15:45547324 G/A cg09092052 chr15:45571596 NA 0.46 6.41 0.33 5.09e-10 Glomerular filtration rate; LUSC cis rs12421382 0.659 rs60143378 chr11:109385513 T/C cg27471124 chr11:109292789 C11orf87 0.43 7.61 0.38 2.86e-13 Schizophrenia; LUSC trans rs12043259 1.000 rs12047348 chr1:204849727 G/A cg23865240 chr7:27134109 HOXA1 -0.57 -6.01 -0.31 4.87e-9 Addiction; LUSC cis rs9811920 0.809 rs35422475 chr3:99711545 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -7.16 -0.36 5.02e-12 Axial length; LUSC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg04944784 chr2:26401820 FAM59B -0.68 -9.69 -0.47 9.62e-20 Gut microbiome composition (summer); LUSC trans rs12210905 1.000 rs5030955 chr6:27213867 C/T cg11837749 chr1:55047332 ACOT11 0.58 6.19 0.32 1.76e-9 Hip circumference adjusted for BMI; LUSC trans rs61931739 0.736 rs7314457 chr12:34454301 G/A cg26384229 chr12:38710491 ALG10B 0.79 13.92 0.61 4.67e-35 Morning vs. evening chronotype; LUSC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg27211696 chr2:191398769 TMEM194B 0.67 12.81 0.57 7.77e-31 Pulse pressure; LUSC cis rs2658782 1.000 rs2605583 chr11:93164957 T/A cg15737290 chr11:93063684 CCDC67 0.66 8.22 0.41 4.59e-15 Pulmonary function decline; LUSC cis rs3736594 0.959 rs10209020 chr2:27980944 C/T cg27432699 chr2:27873401 GPN1 -0.64 -9.19 -0.45 4.17e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2692947 0.567 rs4907276 chr2:96391109 G/T cg22654517 chr2:96458247 NA -0.32 -5.97 -0.31 5.99e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20086523 chr13:52378287 DHRS12 -0.48 -6.49 -0.33 3.05e-10 Bipolar disorder and schizophrenia; LUSC cis rs34172651 0.876 rs2112785 chr16:24781176 C/T cg00339695 chr16:24857497 SLC5A11 0.37 6.56 0.34 1.99e-10 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg06640241 chr16:89574553 SPG7 -0.71 -11.59 -0.54 2.54e-26 Multiple myeloma (IgH translocation); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg02820810 chr13:47127418 LRCH1 0.45 5.99 0.31 5.48e-9 Response to Homoharringtonine (cytotoxicity); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11631883 chr8:101964501 YWHAZ -0.41 -6.06 -0.31 3.63e-9 Hepatitis; LUSC trans rs7939886 0.920 rs11227670 chr11:56026737 A/C cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26264438 chr19:1039942 ABCA7 -0.4 -5.95 -0.31 6.7e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9952991 0.883 rs2847293 chr18:12782448 A/T cg23598886 chr18:12777645 NA 0.64 6.46 0.33 3.72e-10 Inflammatory skin disease; LUSC cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg23788917 chr6:8435910 SLC35B3 0.5 7.4 0.38 1.14e-12 Motion sickness; LUSC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.73 0.51 2.84e-23 Hip circumference adjusted for BMI; LUSC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg15595755 chr5:1867978 NA 0.46 8.36 0.42 1.7e-15 Cardiovascular disease risk factors; LUSC cis rs939658 0.805 rs35832166 chr15:79417994 G/T cg17916960 chr15:79447300 NA -0.52 -10.32 -0.49 7.2e-22 Refractive error; LUSC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg02574844 chr11:5959923 NA -0.42 -5.91 -0.31 8.4e-9 DNA methylation (variation); LUSC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg08859206 chr1:53392774 SCP2 -0.39 -6.45 -0.33 3.82e-10 Monocyte count; LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg11645453 chr3:52864694 ITIH4 0.36 8.18 0.41 5.91e-15 Bipolar disorder; LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg11062466 chr8:58055876 NA 0.75 9.12 0.45 7.24e-18 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.95 0.7 6.41e-51 Chronic sinus infection; LUSC trans rs7615952 0.609 rs13088451 chr3:125553499 G/C cg21747405 chr11:67723411 NA -0.48 -6.33 -0.33 7.7e-10 Blood pressure (smoking interaction); LUSC cis rs6693567 0.565 rs10888584 chr1:150476406 C/G cg15654264 chr1:150340011 RPRD2 0.45 7.16 0.36 5.27e-12 Migraine; LUSC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg13390004 chr1:15929781 NA 0.41 6.9 0.35 2.66e-11 Systolic blood pressure; LUSC cis rs16937 0.503 rs76939335 chr1:205178610 T/C cg00857998 chr1:205179979 DSTYK 0.47 6.66 0.34 1.16e-10 Schizophrenia; LUSC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg05313129 chr8:58192883 C8orf71 -0.5 -6.62 -0.34 1.46e-10 Developmental language disorder (linguistic errors); LUSC trans rs7829975 0.811 rs7011229 chr8:8543324 T/C cg27411982 chr8:10470053 RP1L1 -0.38 -5.95 -0.31 6.93e-9 Mood instability; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.97 -0.51 4.15e-24 Alzheimer's disease; LUSC cis rs6547741 0.904 rs2384628 chr2:27774702 T/G cg12559939 chr2:27858050 GPN1 0.41 6.38 0.33 6.04e-10 Oral cavity cancer; LUSC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg20307385 chr11:47447363 PSMC3 -0.46 -5.89 -0.31 9.27e-9 Subjective well-being; LUSC cis rs12210905 1.000 rs72843609 chr6:27125877 G/A cg11502198 chr6:26597334 ABT1 -0.78 -5.65 -0.3 3.43e-8 Hip circumference adjusted for BMI; LUSC cis rs782590 0.783 rs7594279 chr2:55812073 T/G cg18811423 chr2:55921094 PNPT1 0.83 14.43 0.62 4.83e-37 Metabolic syndrome; LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg26314531 chr2:26401878 FAM59B 0.7 8.89 0.44 3.89e-17 Gut microbiome composition (summer); LUSC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.47 -7.07 -0.36 9.28e-12 Colorectal cancer; LUSC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg12311346 chr5:56204834 C5orf35 -0.79 -12.1 -0.55 3.36e-28 Coronary artery disease; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg10862848 chr6:42927986 GNMT -0.28 -6.61 -0.34 1.5e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11958404 0.932 rs12517979 chr5:157428918 T/C cg05962755 chr5:157440814 NA 0.51 6.13 0.32 2.53e-9 IgG glycosylation; LUSC cis rs1559088 0.749 rs10405757 chr19:33616526 C/A cg03563238 chr19:33554763 RHPN2 -0.37 -5.97 -0.31 6.18e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg14004847 chr7:1930337 MAD1L1 -0.58 -9.1 -0.45 8.35e-18 Bipolar disorder and schizophrenia; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg09436375 chr6:42928200 GNMT -0.3 -6.86 -0.35 3.38e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1801251 1.000 rs13013142 chr2:233600606 A/G cg08000102 chr2:233561755 GIGYF2 0.68 11.29 0.53 2.92e-25 Coronary artery disease; LUSC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg16434002 chr17:42200994 HDAC5 0.44 5.98 0.31 5.59e-9 Total body bone mineral density; LUSC cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.14 0.32 2.33e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg13736514 chr6:26305472 NA -0.46 -9.01 -0.44 1.61e-17 Educational attainment; LUSC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg23583168 chr7:148888333 NA -0.88 -16.54 -0.67 2.57e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4356932 0.691 rs4859413 chr4:76898250 A/G cg00809888 chr4:76862425 NAAA -0.37 -5.99 -0.31 5.41e-9 Blood protein levels; LUSC cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.54 -7.06 -0.36 9.65e-12 Mean platelet volume; LUSC trans rs1997103 1.000 rs12718956 chr7:55407763 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg06238570 chr21:40685208 BRWD1 0.48 7.39 0.38 1.16e-12 Cognitive function; LUSC trans rs7829975 0.688 rs6995407 chr8:8384647 C/G cg21775007 chr8:11205619 TDH 0.46 6.74 0.35 6.76e-11 Mood instability; LUSC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -10.01 -0.48 8.15e-21 Personality dimensions; LUSC cis rs1568889 1.000 rs12791341 chr11:28335452 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 8.84 0.44 5.58e-17 Bipolar disorder; LUSC trans rs61931739 0.635 rs6488185 chr12:33933127 G/C cg13010199 chr12:38710504 ALG10B 0.4 6.03 0.31 4.29e-9 Morning vs. evening chronotype; LUSC cis rs11785400 0.793 rs4430070 chr8:143729184 G/C cg10596483 chr8:143751796 JRK 0.53 7.57 0.38 3.65e-13 Schizophrenia; LUSC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg05896524 chr21:47604654 C21orf56 0.42 6.3 0.33 9.47e-10 Testicular germ cell tumor; LUSC cis rs67696533 0.636 rs6119880 chr20:31105594 G/A cg13636640 chr20:31349939 DNMT3B 0.47 6.38 0.33 5.83e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg00745463 chr17:30367425 LRRC37B -0.85 -9.9 -0.48 2.01e-20 Hip circumference adjusted for BMI; LUSC cis rs6542838 0.588 rs4851174 chr2:99530113 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.5 -6.85 -0.35 3.51e-11 Fear of minor pain; LUSC cis rs8179 0.645 rs6954221 chr7:92283262 A/G cg15732164 chr7:92237376 CDK6 0.43 6.03 0.31 4.39e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs1729951 0.545 rs1097288 chr3:136693721 C/T cg21827317 chr3:136751795 NA 0.39 6.96 0.36 1.83e-11 Neuroticism; LUSC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg27121462 chr16:89883253 FANCA 0.53 8.57 0.42 3.85e-16 Vitiligo; LUSC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg14552801 chr7:65878734 NA 0.44 6.27 0.32 1.12e-9 Aortic root size; LUSC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.53 -0.38 4.74e-13 Personality dimensions; LUSC cis rs6960043 0.818 rs2215383 chr7:15062983 T/C cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC cis rs9287719 0.967 rs4519489 chr2:10739087 A/T cg00105475 chr2:10696890 NA 0.38 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs7937682 0.924 rs501089 chr11:111502479 G/T cg09085632 chr11:111637200 PPP2R1B 1.07 15.49 0.65 3.75e-41 Primary sclerosing cholangitis; LUSC cis rs12950390 0.853 rs56137679 chr17:45862112 C/G cg03474202 chr17:45855739 NA -0.3 -6.93 -0.35 2.14e-11 IgG glycosylation; LUSC trans rs11098499 0.954 rs9998585 chr4:120396802 T/A cg25214090 chr10:38739885 LOC399744 0.56 8.35 0.42 1.8e-15 Corneal astigmatism; LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.82 0.3 1.36e-8 Menopause (age at onset); LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg26354017 chr1:205819088 PM20D1 0.73 12.13 0.55 2.55e-28 Menarche (age at onset); LUSC cis rs3106136 0.967 rs11097411 chr4:95222626 C/T cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.14 -0.32 2.38e-9 Capecitabine sensitivity; LUSC cis rs4589502 0.800 rs12595796 chr15:67202599 A/G cg09911534 chr15:67153556 NA 0.5 6.5 0.34 2.92e-10 Lung cancer (smoking interaction); LUSC cis rs9527 0.590 rs10786744 chr10:104945028 A/C cg04362960 chr10:104952993 NT5C2 -0.6 -9.53 -0.46 3.29e-19 Arsenic metabolism; LUSC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg11062466 chr8:58055876 NA 0.47 6.31 0.33 8.87e-10 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg08270630 chr22:50330655 NA -0.42 -6.46 -0.33 3.73e-10 Schizophrenia; LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg22166914 chr1:53195759 ZYG11B 0.6 9.8 0.47 4.26e-20 Monocyte count; LUSC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg12257692 chr3:49977190 RBM6 -0.24 -6.42 -0.33 4.77e-10 Intelligence (multi-trait analysis); LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg16647868 chr5:131706066 SLC22A5 -0.38 -5.81 -0.3 1.45e-8 Breast cancer; LUSC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg07636037 chr3:49044803 WDR6 0.56 5.73 0.3 2.24e-8 Menarche (age at onset); LUSC cis rs6696846 0.630 rs6692706 chr1:205158561 G/T cg00857998 chr1:205179979 DSTYK 0.66 10.24 0.49 1.44e-21 Red blood cell count; LUSC cis rs7786877 0.521 rs4729606 chr7:100321790 T/C cg16850897 chr7:100343110 ZAN -0.55 -7.69 -0.39 1.63e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg16928487 chr17:17741425 SREBF1 0.37 7.1 0.36 7.37e-12 Total body bone mineral density; LUSC cis rs1950500 0.545 rs1950501 chr14:24806800 C/G cg16194253 chr14:24768981 DHRS1;C14orf21 0.57 9.39 0.46 9.91e-19 Height; LUSC cis rs244293 0.965 rs244303 chr17:53238728 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.4 -5.79 -0.3 1.65e-8 Menarche (age at onset); LUSC cis rs886126 1.000 rs886126 chr12:111679214 C/T cg10833066 chr12:111807467 FAM109A 0.39 6.47 0.33 3.41e-10 Coronary heart disease; LUSC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg17294928 chr15:75287854 SCAMP5 -0.93 -13.47 -0.59 2.47e-33 Blood trace element (Zn levels); LUSC cis rs281408 0.559 rs281381 chr19:49214748 C/T cg21064579 chr19:49206444 FUT2 0.34 5.96 0.31 6.54e-9 Urinary metabolites (H-NMR features); LUSC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.66 0.39 2.05e-13 Eosinophil percentage of white cells; LUSC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg18876405 chr7:65276391 NA 0.75 13.71 0.6 3.03e-34 Calcium levels; LUSC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg18099408 chr3:52552593 STAB1 0.34 5.87 0.31 1.05e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.39 0.46 1e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.44 -6.2 -0.32 1.66e-9 Osteoporosis; LUSC cis rs9527 0.590 rs726010 chr10:104841977 C/T cg04362960 chr10:104952993 NT5C2 0.62 9.49 0.46 4.58e-19 Arsenic metabolism; LUSC cis rs66486766 1 rs66486766 chr15:84806060 G/A cg17507749 chr15:85114479 UBE2QP1 0.69 8.66 0.43 2.11e-16 Bipolar disorder lithium response (categorical) or schizophrenia; LUSC cis rs4654899 0.897 rs3736880 chr1:21097727 G/A cg01072550 chr1:21505969 NA -0.47 -7.12 -0.36 6.76e-12 Superior frontal gyrus grey matter volume; LUSC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg10523679 chr1:76189770 ACADM -0.84 -11.05 -0.52 2.1e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4285028 0.948 rs2332033 chr3:121699548 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.71 -9.1 -0.45 8.65e-18 Multiple sclerosis; LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg05896524 chr21:47604654 C21orf56 -0.57 -8.9 -0.44 3.65e-17 Testicular germ cell tumor; LUSC cis rs6665290 0.904 rs1343744 chr1:227183022 C/T cg10327440 chr1:227177885 CDC42BPA -1.2 -37.29 -0.9 4.27e-121 Myeloid white cell count; LUSC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.67 0.54 1.3e-26 Hip circumference adjusted for BMI; LUSC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg08859206 chr1:53392774 SCP2 0.46 7.68 0.39 1.78e-13 Monocyte count; LUSC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg03678062 chr6:149772716 ZC3H12D -0.32 -6.76 -0.35 6.16e-11 Dupuytren's disease; LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg27170947 chr2:26402098 FAM59B -0.64 -9.23 -0.45 3.23e-18 Gut microbiome composition (summer); LUSC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.4 -6.39 -0.33 5.68e-10 Total body bone mineral density; LUSC cis rs7937682 0.855 rs11213985 chr11:111581521 C/A cg22437258 chr11:111473054 SIK2 0.5 6.87 0.35 3.14e-11 Primary sclerosing cholangitis; LUSC cis rs2806561 0.664 rs55764475 chr1:23318983 C/T cg12483005 chr1:23474871 LUZP1 0.41 6.08 0.32 3.19e-9 Height; LUSC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg05802129 chr4:122689817 NA -0.34 -5.97 -0.31 6.02e-9 Type 2 diabetes; LUSC cis rs10876993 0.890 rs812304 chr12:58074853 A/C cg18357645 chr12:58087776 OS9 0.55 8.21 0.41 4.97e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg16339924 chr4:17578868 LAP3 -0.53 -7.92 -0.4 3.68e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.48 6.01 0.31 4.75e-9 Renal function-related traits (BUN); LUSC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg02896835 chr1:92012615 NA 0.62 11.16 0.52 8.3e-25 Breast cancer; LUSC trans rs11722228 1.000 rs4697695 chr4:9915850 C/T cg26043149 chr18:55253948 FECH 0.62 9.27 0.45 2.39e-18 Gout;Urate levels;Serum uric acid levels; LUSC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg13206674 chr6:150067644 NUP43 0.55 8.46 0.42 8.38e-16 Lung cancer; LUSC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.26 0.59 1.63e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs5769707 0.609 rs2007024 chr22:49988815 C/T cg10356904 chr22:49881777 NA -0.28 -5.72 -0.3 2.41e-8 Monocyte count;Monocyte percentage of white cells; LUSC trans rs11098499 0.644 rs10050092 chr4:120532085 T/C cg25214090 chr10:38739885 LOC399744 0.43 6.7 0.34 9.07e-11 Corneal astigmatism; LUSC cis rs10504073 0.669 rs55948643 chr8:50026403 C/G cg00325661 chr8:49890786 NA 0.6 9.79 0.47 4.68e-20 Blood metabolite ratios; LUSC cis rs13392177 0.637 rs61041183 chr2:219056380 G/A cg00012203 chr2:219082015 ARPC2 0.79 13.58 0.6 9.7e-34 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs61931739 0.817 rs10772143 chr12:34230651 T/G cg06521331 chr12:34319734 NA -0.37 -6.46 -0.33 3.79e-10 Morning vs. evening chronotype; LUSC cis rs9788682 0.947 rs12439240 chr15:78829091 T/C cg06917634 chr15:78832804 PSMA4 -0.58 -7.03 -0.36 1.17e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs7980799 0.649 rs7972688 chr12:33653477 T/C cg26384229 chr12:38710491 ALG10B -0.56 -8.07 -0.4 1.24e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs61931739 0.517 rs1844525 chr12:34103183 T/A cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg23172400 chr8:95962367 TP53INP1 0.37 7.48 0.38 6.46e-13 Type 2 diabetes; LUSC cis rs12310956 0.532 rs11052933 chr12:33969881 G/A cg06521331 chr12:34319734 NA -0.46 -7.3 -0.37 2.12e-12 Morning vs. evening chronotype; LUSC cis rs7828089 0.935 rs4872485 chr8:22255990 G/T cg12081754 chr8:22256438 SLC39A14 0.59 9.42 0.46 7.87e-19 Verbal declarative memory; LUSC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg11752832 chr7:134001865 SLC35B4 0.56 8.39 0.42 1.44e-15 Mean platelet volume; LUSC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg13390004 chr1:15929781 NA 0.4 6.68 0.34 1e-10 Systolic blood pressure; LUSC cis rs6496044 0.611 rs6496055 chr15:86070688 A/G cg13263323 chr15:86062960 AKAP13 -0.38 -6.29 -0.33 9.78e-10 Interstitial lung disease; LUSC cis rs11098499 0.820 rs13122709 chr4:120555356 T/A cg09307838 chr4:120376055 NA 0.72 10.4 0.49 3.93e-22 Corneal astigmatism; LUSC cis rs9815354 0.516 rs75047809 chr3:42033437 T/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs16917546 1.000 rs16917546 chr10:64397538 T/C cg03961010 chr10:64397487 ZNF365 -0.42 -6.73 -0.35 7.45e-11 Basal cell carcinoma; LUSC cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg11266682 chr4:10021025 SLC2A9 0.43 7.62 0.38 2.61e-13 Bone mineral density; LUSC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg13393036 chr8:95962371 TP53INP1 -0.46 -9.65 -0.47 1.33e-19 Type 2 diabetes; LUSC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg26513180 chr16:89883248 FANCA 0.91 17.79 0.7 2.82e-50 Vitiligo; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg16325326 chr1:53192061 ZYG11B -0.83 -14.46 -0.62 3.87e-37 Monocyte count; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg12432903 chr7:1882776 MAD1L1 -0.51 -8.74 -0.43 1.19e-16 Bipolar disorder and schizophrenia; LUSC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg06238570 chr21:40685208 BRWD1 0.49 7.32 0.37 1.86e-12 Cognitive function; LUSC cis rs698813 0.572 rs6544749 chr2:44478077 G/A cg00619915 chr2:44497795 NA -0.53 -7.41 -0.38 1.03e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs6762477 0.748 rs2073726 chr3:50223593 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.09 -0.36 7.79e-12 Menarche (age at onset); LUSC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg17376030 chr22:41985996 PMM1 -0.51 -6.33 -0.33 7.87e-10 Vitiligo; LUSC trans rs7474896 0.561 rs2474603 chr10:38445682 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -6.2 -0.32 1.67e-9 Obesity (extreme); LUSC cis rs10911232 0.524 rs4652773 chr1:183054827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.11 0.52 1.29e-24 Hypertriglyceridemia; LUSC cis rs3126085 0.935 rs12045496 chr1:152253910 A/G cg26876637 chr1:152193138 HRNR 0.45 6.08 0.32 3.31e-9 Atopic dermatitis; LUSC cis rs8077889 0.672 rs1230397 chr17:41844689 A/G cg26893861 chr17:41843967 DUSP3 1.13 26.74 0.83 5.26e-85 Triglycerides; LUSC cis rs116988415 0.584 rs4902311 chr14:65241933 G/A cg00114569 chr14:65239327 SPTB 0.66 6.4 0.33 5.23e-10 Daytime sleep phenotypes; LUSC cis rs240764 0.658 rs12202621 chr6:101220056 C/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.29e-9 Neuroticism; LUSC cis rs12940923 1.000 rs11658637 chr17:56376508 A/G cg19466818 chr17:56409534 MIR142 -0.38 -6.51 -0.34 2.71e-10 Circulating myeloperoxidase levels (plasma); LUSC trans rs7681440 0.904 rs6532193 chr4:90764188 G/A cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.01 -0.31 4.92e-9 Dementia with Lewy bodies; LUSC cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg23583168 chr7:148888333 NA -0.8 -13.29 -0.59 1.16e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg10523679 chr1:76189770 ACADM -0.51 -7.46 -0.38 7.52e-13 Daytime sleep phenotypes; LUSC cis rs534126 0.813 rs526867 chr7:142904427 G/A cg04039957 chr7:143013207 CLCN1 0.31 5.92 0.31 8.18e-9 Cancer; LUSC cis rs12470837 1 rs12470837 chr2:132582511 T/C cg16789863 chr2:132589606 NA 0.41 6.24 0.32 1.32e-9 Cerebrospinal fluid clusterin levels in APOEe4+ carriers;Cerebrospinal fluid clusterin levels; LUSC trans rs7726839 0.794 rs10474792 chr5:600058 G/A cg25482853 chr8:67687455 SGK3 0.8 11.01 0.52 2.92e-24 Obesity-related traits; LUSC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg15921436 chr17:44337874 NA -0.71 -10.77 -0.51 2.0500000000000001e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs6967385 0.560 rs10254029 chr7:12343148 G/C cg20607287 chr7:12443886 VWDE 0.46 6.88 0.35 2.89e-11 Response to taxane treatment (placlitaxel); LUSC cis rs11792861 0.781 rs17729408 chr9:111740860 A/G cg13535736 chr9:111863775 C9orf5 0.37 5.98 0.31 5.58e-9 Menarche (age at onset); LUSC cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.07 0.44 1.05e-17 Prostate cancer (SNP x SNP interaction); LUSC trans rs587847 0.507 rs1563576 chr15:37793620 C/T cg18296784 chr11:116147929 NA -0.34 -6.09 -0.32 3.08e-9 Intraocular pressure; LUSC cis rs1801251 1.000 rs12987513 chr2:233622066 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.56 0.34 2.03e-10 Coronary artery disease; LUSC trans rs61931739 0.534 rs7133262 chr12:34279444 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.72 0.54 8.22e-27 Morning vs. evening chronotype; LUSC cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.41 -7.68 -0.39 1.79e-13 Monocyte percentage of white cells; LUSC cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg15103426 chr22:29168792 CCDC117 0.48 6.3 0.33 9.32e-10 Lymphocyte counts; LUSC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.69 0.39 1.7e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs782590 0.967 rs1975487 chr2:55809054 A/G cg03859395 chr2:55845619 SMEK2 0.86 15.64 0.65 9.08e-42 Metabolic syndrome; LUSC cis rs9814567 0.896 rs7642266 chr3:134346025 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -5.77 -0.3 1.84e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7759001 0.857 rs6935116 chr6:27354949 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.74 0.3 2.1e-8 Glomerular filtration rate (creatinine); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg06420324 chr11:73309256 FAM168A -0.43 -5.97 -0.31 6.12e-9 Cognitive function;Information processing speed; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.3 0.41 2.67e-15 Prudent dietary pattern; LUSC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg13010344 chr12:123464640 ARL6IP4 -0.47 -7.1 -0.36 7.72e-12 Neutrophil percentage of white cells; LUSC cis rs2404602 0.692 rs35170561 chr15:77130695 C/T cg23625390 chr15:77176239 SCAPER 0.46 7.01 0.36 1.35e-11 Blood metabolite levels; LUSC trans rs6601450 0.579 rs11775625 chr8:10272439 C/T cg15556689 chr8:8085844 FLJ10661 0.42 6.28 0.32 1.05e-9 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg17971929 chr21:40555470 PSMG1 0.8 14.09 0.61 1.04e-35 Cognitive function; LUSC cis rs9560113 1.000 rs9555812 chr13:112181535 A/G cg14154082 chr13:112174009 NA 0.38 7.88 0.4 4.53e-14 Menarche (age at onset); LUSC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.83 0.3 1.3e-8 Life satisfaction; LUSC cis rs12458462 0.812 rs36073957 chr18:77488441 C/T cg11879182 chr18:77439856 CTDP1 0.7 10.45 0.5 2.56e-22 Monocyte count; LUSC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg18252515 chr7:66147081 NA 1.23 14.01 0.61 2.04e-35 Diabetic kidney disease; LUSC cis rs6469656 0.685 rs4629900 chr8:117767621 T/C cg24004040 chr8:117650383 NA -0.43 -6.17 -0.32 1.92e-9 Colorectal cancer; LUSC cis rs73206853 0.841 rs17792048 chr12:110866543 C/A cg12870014 chr12:110450643 ANKRD13A 0.65 6.08 0.32 3.25e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg04775059 chr7:64541387 NA 0.53 7.78 0.39 8.84e-14 Calcium levels; LUSC cis rs8060686 0.641 rs75297764 chr16:68212820 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7707921 1.000 rs7707921 chr5:81538046 T/A cg15871215 chr5:81402204 ATG10 0.44 6.54 0.34 2.36e-10 Breast cancer; LUSC cis rs12681287 0.547 rs7837569 chr8:87507366 C/T cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg05347473 chr6:146136440 FBXO30 0.56 9.66 0.47 1.23e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg02475777 chr4:1388615 CRIPAK -0.58 -8.81 -0.43 6.88e-17 Obesity-related traits; LUSC cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg18132916 chr6:79620363 NA -0.37 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg23985595 chr17:80112537 CCDC57 -0.3 -5.85 -0.31 1.15e-8 Life satisfaction; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg25703541 chr22:24373054 LOC391322 -0.84 -12.47 -0.56 1.45e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs5758511 0.680 rs5758698 chr22:42684818 C/T cg00645731 chr22:42541494 CYP2D7P1 0.56 9.38 0.46 1.02e-18 Birth weight; LUSC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg20135002 chr11:47629003 NA -0.43 -6.98 -0.36 1.6e-11 Subjective well-being; LUSC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg00343986 chr7:65444356 GUSB -0.43 -6.59 -0.34 1.71e-10 Aortic root size; LUSC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg15147215 chr3:52552868 STAB1 -0.32 -6.31 -0.33 9e-10 Electroencephalogram traits; LUSC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg09365446 chr1:150670422 GOLPH3L 0.51 7.45 0.38 7.94e-13 Melanoma; LUSC cis rs9560113 1.000 rs4773384 chr13:112177987 A/G cg14154082 chr13:112174009 NA 0.38 7.76 0.39 1.03e-13 Menarche (age at onset); LUSC cis rs7605827 0.930 rs6431696 chr2:15540009 C/A cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg20503657 chr10:835505 NA 0.98 13.74 0.6 2.26e-34 Eosinophil percentage of granulocytes; LUSC cis rs9790314 1.000 rs28515190 chr3:161028605 G/A cg03342759 chr3:160939853 NMD3 -0.49 -8.16 -0.41 6.68e-15 Morning vs. evening chronotype; LUSC cis rs6940638 0.688 rs2022272 chr6:27103580 A/G cg05738196 chr6:26577821 NA -0.49 -7.04 -0.36 1.09e-11 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18943949 chr22:19842501 GNB1L;C22orf29 -0.44 -6.6 -0.34 1.57e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.93 0.44 2.95e-17 Prudent dietary pattern; LUSC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg10523679 chr1:76189770 ACADM -0.89 -11.99 -0.55 8.32e-28 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs2262909 0.962 rs55735642 chr19:22241176 C/T cg17074339 chr11:11642133 GALNTL4 0.47 7.17 0.37 4.94e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Bladder cancer; LUSC cis rs3820928 0.874 rs10933163 chr2:227815286 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.14e-13 Pulmonary function; LUSC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22509189 chr2:225307070 NA -0.49 -6.35 -0.33 6.84e-10 IgE levels in asthmatics (D.p. specific); LUSC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00475322 chr7:917719 C7orf20 0.44 6.52 0.34 2.6200000000000003e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg16339924 chr4:17578868 LAP3 0.55 8.43 0.42 1.03e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7577851 0.625 rs55885494 chr2:69556144 A/C cg10773587 chr2:69614142 GFPT1 0.59 6.41 0.33 5.08e-10 Parkinson's disease (age of onset); LUSC cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg22681709 chr2:178499509 PDE11A -0.51 -9.13 -0.45 6.65e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg09365446 chr1:150670422 GOLPH3L 0.49 7.17 0.37 4.77e-12 Melanoma; LUSC cis rs9300255 0.679 rs28583837 chr12:123863620 G/A cg13010344 chr12:123464640 ARL6IP4 0.52 6.41 0.33 4.94e-10 Neutrophil percentage of white cells; LUSC cis rs734999 0.524 rs4648448 chr1:2695687 C/T cg18854424 chr1:2615690 NA 0.49 9.44 0.46 6.81e-19 Ulcerative colitis; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg08742575 chr21:47604166 C21orf56 -0.44 -6.78 -0.35 5.54e-11 Testicular germ cell tumor; LUSC cis rs73416724 1.000 rs41281796 chr6:43323917 G/A cg26312998 chr6:43337775 ZNF318 0.57 6.66 0.34 1.16e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs1152591 0.643 rs3020449 chr14:64773392 C/T cg21174375 chr14:64681225 SYNE2 -0.32 -5.9 -0.31 9.12e-9 Atrial fibrillation; LUSC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.49e-10 Extrinsic epigenetic age acceleration; LUSC cis rs4481887 0.800 rs4639798 chr1:248515703 A/G cg26353448 chr1:248524236 OR2T4 -0.32 -6.01 -0.31 4.91e-9 Common traits (Other); LUSC cis rs826838 0.935 rs11169511 chr12:39175802 T/C cg26384229 chr12:38710491 ALG10B 0.89 16.94 0.68 7.06e-47 Heart rate; LUSC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg07636037 chr3:49044803 WDR6 0.44 6.28 0.32 1.07e-9 Resting heart rate; LUSC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg09365446 chr1:150670422 GOLPH3L 0.5 7.25 0.37 2.95e-12 Melanoma; LUSC trans rs953492 0.672 rs10926964 chr1:243359347 G/A cg25284624 chr1:224180302 NA -0.5 -7.7 -0.39 1.56e-13 Diastolic blood pressure; LUSC cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -7.61 -0.38 2.91e-13 Chronic sinus infection; LUSC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg06008330 chr7:65541103 ASL 0.37 5.68 0.3 2.98e-8 Aortic root size; LUSC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg06656553 chr16:89960601 TCF25 -0.65 -5.7 -0.3 2.63e-8 Skin colour saturation; LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18099408 chr3:52552593 STAB1 -0.48 -8.76 -0.43 1.02e-16 Cognitive function; LUSC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg06656553 chr16:89960601 TCF25 -0.63 -5.7 -0.3 2.68e-8 Skin colour saturation; LUSC cis rs6920965 0.507 rs7754833 chr6:126190894 A/G cg10911889 chr6:126070802 HEY2 0.39 5.66 0.3 3.34e-8 High light scatter reticulocyte count; LUSC cis rs6901250 0.851 rs339324 chr6:117195024 C/T cg12892004 chr6:117198278 RFX6 -0.45 -8.55 -0.42 4.56e-16 C-reactive protein levels; LUSC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9325144 0.671 rs7486919 chr12:38767997 A/G cg13010199 chr12:38710504 ALG10B -0.5 -7.49 -0.38 6.05e-13 Morning vs. evening chronotype; LUSC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg24531977 chr5:56204891 C5orf35 0.61 8.99 0.44 1.84e-17 Coronary artery disease; LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg26314531 chr2:26401878 FAM59B -0.7 -9.64 -0.47 1.4e-19 Gut microbiome composition (summer); LUSC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg13390004 chr1:15929781 NA 0.42 7.02 0.36 1.23e-11 Systolic blood pressure; LUSC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg23711669 chr6:146136114 FBXO30 0.88 16.13 0.66 1.12e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs16937 0.662 rs12137294 chr1:205182872 A/C cg00857998 chr1:205179979 DSTYK 0.4 5.83 0.3 1.34e-8 Schizophrenia; LUSC cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.63 0.85 1.69e-95 Chronic sinus infection; LUSC cis rs240764 0.658 rs6909880 chr6:101179354 A/C cg09795085 chr6:101329169 ASCC3 -0.46 -6.65 -0.34 1.2e-10 Neuroticism; LUSC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg18230493 chr5:56204884 C5orf35 -0.65 -9.99 -0.48 1e-20 Coronary artery disease; LUSC cis rs478304 0.934 rs12801731 chr11:65549606 T/C cg27068330 chr11:65405492 SIPA1 0.65 9.82 0.47 3.71e-20 Acne (severe); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg22506841 chr1:200271513 NA 0.41 6.25 0.32 1.24e-9 N-glycan levels; LUSC cis rs6840360 0.571 rs62327268 chr4:152522326 T/A cg22705602 chr4:152727874 NA -0.33 -6.61 -0.34 1.53e-10 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.517 rs1844525 chr12:34103183 T/A cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg15145296 chr3:125709740 NA -0.58 -6.5 -0.33 3e-10 Blood pressure (smoking interaction); LUSC cis rs3845702 0.736 rs72960701 chr2:180851202 A/T cg01881094 chr2:180872142 CWC22 1.04 12.49 0.56 1.28e-29 Schizophrenia; LUSC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg18099408 chr3:52552593 STAB1 0.35 5.96 0.31 6.38e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs1997103 0.871 rs1997101 chr7:55399652 A/T cg20935933 chr6:143382018 AIG1 0.51 7.4 0.38 1.08e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1832871 0.711 rs6906854 chr6:158695000 C/T cg07165851 chr6:158734300 TULP4 0.5 7.8 0.39 7.87e-14 Height; LUSC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.83 -0.39 6.56e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg20790798 chr5:1857306 NA -0.5 -8.7 -0.43 1.52e-16 Cardiovascular disease risk factors; LUSC cis rs4474465 0.850 rs10793328 chr11:78256868 A/G cg27205649 chr11:78285834 NARS2 0.55 6.52 0.34 2.59e-10 Alzheimer's disease (survival time); LUSC cis rs977987 0.806 rs7199132 chr16:75450039 C/T cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.68e-17 Dupuytren's disease; LUSC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.47 6.98 0.36 1.62e-11 Schizophrenia; LUSC cis rs6591341 0.515 rs599301 chr11:68189945 G/C cg01657329 chr11:68192670 LRP5 -0.47 -7.13 -0.36 6.43e-12 Lean body mass; LUSC cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg24596788 chr1:163392923 NA -0.44 -7.53 -0.38 4.62e-13 Motion sickness; LUSC cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.81 0.43 6.77e-17 Axial length; LUSC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg05084668 chr3:125655381 ALG1L -0.49 -6.98 -0.36 1.61e-11 Blood pressure (smoking interaction); LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg06877462 chr1:205807181 PM20D1 0.39 7.32 0.37 1.86e-12 Menarche (age at onset); LUSC trans rs1728785 1.000 rs1645927 chr16:68589300 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.29 0.41 2.71e-15 Ulcerative colitis; LUSC cis rs6847149 0.810 rs2347134 chr4:110814457 A/T cg07850274 chr4:110748770 RRH 0.5 7.03 0.36 1.19e-11 Exercise treadmill test traits; LUSC cis rs354225 0.544 rs3796018 chr2:54807281 C/T cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC trans rs2055729 0.634 rs6601390 chr8:9740657 A/G cg06636001 chr8:8085503 FLJ10661 0.48 6.0 0.31 5.08e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs6964587 0.967 rs17164315 chr7:91659150 C/G cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.08e-8 Breast cancer; LUSC cis rs2637266 1.000 rs2579761 chr10:78321040 C/T cg18941641 chr10:78392320 NA 0.38 7.0 0.36 1.41e-11 Pulmonary function; LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.52 0.59 1.57e-33 Platelet count; LUSC cis rs7208859 0.573 rs4055105 chr17:29102550 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.28 0.37 2.45e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4129767 0.647 rs1976703 chr17:76401328 C/T cg05887092 chr17:76393375 PGS1 0.62 12.01 0.55 7.33e-28 HDL cholesterol; LUSC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs1865721 0.771 rs7236311 chr18:73137450 A/G cg26385618 chr18:73139727 C18orf62 -0.55 -10.15 -0.49 2.88e-21 Intelligence; LUSC cis rs2078087 0.522 rs549191 chr1:183220937 A/G cg13843938 chr1:183241246 NMNAT2 0.38 6.43 0.33 4.37e-10 Obesity-related traits; LUSC cis rs968451 0.789 rs11089939 chr22:39680957 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.7 10.17 0.49 2.47e-21 Primary biliary cholangitis; LUSC cis rs9788682 1.000 rs7164594 chr15:78803057 C/T cg24631222 chr15:78858424 CHRNA5 0.78 10.9 0.51 7.32e-24 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00529946 chr2:26568848 SELI;GPR113 -0.48 -6.27 -0.32 1.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs9399135 0.967 rs11756988 chr6:135347595 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.28 0.45 2.26e-18 Red blood cell count; LUSC cis rs992157 0.710 rs12996912 chr2:219110555 A/G cg00012203 chr2:219082015 ARPC2 0.89 17.09 0.68 1.71e-47 Colorectal cancer; LUSC cis rs4242434 0.892 rs34269854 chr8:22465160 G/C cg03733263 chr8:22462867 KIAA1967 0.99 18.14 0.7 1.19e-51 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg05340658 chr4:99064831 C4orf37 0.59 9.37 0.46 1.14e-18 Colonoscopy-negative controls vs population controls; LUSC trans rs417096 1.000 rs302604 chr6:39731420 A/C cg17457912 chr17:1617102 C17orf91 0.31 5.99 0.31 5.43e-9 Hypospadias; LUSC cis rs4595586 0.545 rs925829 chr12:39364167 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC cis rs68170813 0.641 rs12534124 chr7:107119047 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.7 -0.3 2.61e-8 Coronary artery disease; LUSC cis rs4409675 0.576 rs6703851 chr1:28237556 G/A cg23691781 chr1:28212827 C1orf38 0.32 7.54 0.38 4.34e-13 Corneal astigmatism; LUSC cis rs9902453 0.817 rs55758314 chr17:28173978 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.69 0.47 9.71e-20 Coffee consumption (cups per day); LUSC trans rs4553720 0.896 rs4383250 chr18:62177797 A/T cg24311272 chr6:56820869 BEND6;DST 0.46 6.28 0.32 1.03e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); LUSC trans rs12682352 0.602 rs6993494 chr8:8667444 C/T cg27411982 chr8:10470053 RP1L1 0.41 6.12 0.32 2.65e-9 Neuroticism; LUSC cis rs16989760 0.661 rs67935422 chr22:32020413 G/A cg01338084 chr22:32026380 PISD 0.86 6.23 0.32 1.43e-9 Age-related hearing impairment; LUSC cis rs10028773 0.700 rs7671797 chr4:120248157 A/G cg24375607 chr4:120327624 NA 0.76 12.27 0.56 8.02e-29 Educational attainment; LUSC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -6.04 -0.31 4.02e-9 Intelligence (multi-trait analysis); LUSC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg16680214 chr1:154839983 KCNN3 -0.52 -9.48 -0.46 4.88e-19 Prostate cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15995771 chr1:59250858 JUN -0.49 -5.96 -0.31 6.27e-9 Bipolar disorder and schizophrenia; LUSC cis rs10779751 0.770 rs1057079 chr1:11205058 A/G cg08854313 chr1:11322531 MTOR -0.87 -13.41 -0.59 4.38e-33 Body mass index; LUSC cis rs981844 0.890 rs62325113 chr4:154692555 A/G cg14289246 chr4:154710475 SFRP2 0.55 6.9 0.35 2.6e-11 Response to statins (LDL cholesterol change); LUSC cis rs7927592 0.913 rs7104345 chr11:68316772 G/A cg16797656 chr11:68205561 LRP5 0.38 6.23 0.32 1.4e-9 Total body bone mineral density; LUSC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg17385448 chr1:15911702 AGMAT 0.37 6.15 0.32 2.19e-9 Systolic blood pressure; LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg02153584 chr22:29168773 CCDC117 0.59 8.91 0.44 3.47e-17 Lymphocyte counts; LUSC cis rs7189233 0.955 rs7184800 chr16:53509131 G/A cg04059762 chr16:53544020 NA -0.32 -5.75 -0.3 2.01e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.84 10.86 0.51 9.77e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg09035930 chr12:129282057 SLC15A4 0.74 16.25 0.66 3.7e-44 Systemic lupus erythematosus; LUSC trans rs7746199 0.736 rs10484399 chr6:27534528 A/G cg06606381 chr12:133084897 FBRSL1 -0.92 -9.39 -0.46 9.67e-19 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs7119167 0.686 rs7936102 chr11:73044215 T/C cg17517138 chr11:73019481 ARHGEF17 0.49 5.71 0.3 2.49e-8 Blood protein levels; LUSC cis rs6084875 0.812 rs2093386 chr20:4724313 A/G cg07258627 chr20:4721683 PRNT -0.35 -6.22 -0.32 1.52e-9 Systemic lupus erythematosus; LUSC trans rs7170930 0.618 rs55677817 chr15:66541800 G/A cg06396762 chr16:3202609 NA -0.72 -5.98 -0.31 5.75e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1568889 1.000 rs12802830 chr11:28321196 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 8.77 0.43 9.59e-17 Bipolar disorder; LUSC cis rs6500602 0.855 rs2304631 chr16:4475868 A/T cg08645402 chr16:4508243 NA 0.53 8.21 0.41 4.76e-15 Schizophrenia; LUSC cis rs274567 0.599 rs11242110 chr5:131743777 A/C cg12564285 chr5:131593104 PDLIM4 -0.35 -6.14 -0.32 2.33e-9 Blood metabolite levels; LUSC trans rs8002861 0.641 rs4942252 chr13:44443039 C/T cg12856521 chr11:46389249 DGKZ 0.43 6.28 0.32 1.04e-9 Leprosy; LUSC cis rs58785573 0.624 rs337605 chr4:38647753 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.42 6.23 0.32 1.4e-9 Lymphocyte percentage of white cells; LUSC cis rs477692 0.789 rs506915 chr10:131398005 A/G cg26102564 chr10:131424627 MGMT 0.42 6.6 0.34 1.64e-10 Response to temozolomide; LUSC cis rs2073300 1.000 rs6137966 chr20:23444359 A/T cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg20243544 chr17:37824526 PNMT 0.39 5.73 0.3 2.24e-8 Self-reported allergy; LUSC cis rs2742234 0.541 rs11238479 chr10:43717423 C/T cg15436174 chr10:43711423 RASGEF1A 0.45 7.34 0.37 1.69e-12 Hirschsprung disease; LUSC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg15534755 chr11:117069859 TAGLN 0.34 5.92 0.31 7.78e-9 Blood protein levels; LUSC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12667521 chr19:29218732 NA 0.62 8.6 0.43 3.11e-16 Methadone dose in opioid dependence; LUSC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg14440974 chr22:39074834 NA -0.36 -5.95 -0.31 6.89e-9 Menopause (age at onset); LUSC cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.54 6.61 0.34 1.51e-10 Schizophrenia; LUSC cis rs7177699 0.557 rs4433781 chr15:79121835 A/T cg00540400 chr15:79124168 NA -0.48 -8.23 -0.41 4.18e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs17433780 0.504 rs4142706 chr1:89475230 A/C cg09516651 chr1:89888402 LOC400759 0.4 7.12 0.36 6.57e-12 Carotid intima media thickness; LUSC cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.61 -0.57 4.37e-30 Chronic sinus infection; LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18758796 chr5:131593413 PDLIM4 0.53 9.17 0.45 4.99e-18 Acylcarnitine levels; LUSC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg26597838 chr10:835615 NA 0.79 9.73 0.47 7.58e-20 Eosinophil percentage of granulocytes; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02841933 chr7:129251651 NRF1 -0.44 -6.63 -0.34 1.39e-10 Electrocardiographic conduction measures; LUSC cis rs911119 0.913 rs6048926 chr20:23580987 C/A cg16589663 chr20:23618590 CST3 0.62 7.41 0.38 1.04e-12 Chronic kidney disease; LUSC cis rs10904908 0.733 rs359298 chr10:17334176 C/T cg01003015 chr10:17271136 VIM 0.43 6.32 0.33 8.26e-10 Total cholesterol levels;Cholesterol, total; LUSC cis rs6120849 1.000 rs6120849 chr20:33730387 C/T cg24642439 chr20:33292090 TP53INP2 0.55 6.21 0.32 1.56e-9 Protein C levels; LUSC cis rs2836633 0.929 rs11702165 chr21:40035313 C/T cg12884169 chr21:40033163 ERG 0.61 12.36 0.56 3.6e-29 Coronary artery disease; LUSC cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs7267979 1.000 rs6050547 chr20:25326012 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.94 -0.75 8.99e-63 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.4 0.62 6.35e-37 Platelet count; LUSC cis rs7474896 0.515 rs594594 chr10:38307723 A/G cg25427524 chr10:38739819 LOC399744 0.48 6.21 0.32 1.61e-9 Obesity (extreme); LUSC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2573652 1.000 rs2581359 chr15:100513707 A/G cg09918751 chr15:100517450 ADAMTS17 -0.44 -8.06 -0.4 1.33e-14 Height; LUSC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg02487422 chr3:49467188 NICN1 0.45 7.04 0.36 1.12e-11 Resting heart rate; LUSC cis rs2180341 0.538 rs3756993 chr6:127651551 A/C cg27446573 chr6:127587934 RNF146 0.62 9.94 0.48 1.46e-20 Breast cancer; LUSC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg17340268 chr14:105411764 AHNAK2 0.4 6.37 0.33 6.15e-10 Rheumatoid arthritis; LUSC cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg05347473 chr6:146136440 FBXO30 0.55 9.47 0.46 5.29e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7432375 0.610 rs6793936 chr3:136509793 A/C cg15507776 chr3:136538369 TMEM22 0.43 7.22 0.37 3.5e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs4930561 0.714 rs1540209 chr11:67928520 A/C cg04465784 chr11:67976953 SUV420H1 -0.29 -5.8 -0.3 1.53e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs61931739 0.500 rs10844845 chr12:34381117 C/T cg06521331 chr12:34319734 NA -0.41 -6.79 -0.35 5.17e-11 Morning vs. evening chronotype; LUSC cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg05855489 chr10:104503620 C10orf26 0.61 9.82 0.47 3.67e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.91 -0.4 3.82e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9329221 0.935 rs3750310 chr8:10283426 G/A cg27411982 chr8:10470053 RP1L1 -0.45 -6.86 -0.35 3.35e-11 Neuroticism; LUSC cis rs6542838 0.641 rs7565510 chr2:99494833 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.04 -0.31 4e-9 Fear of minor pain; LUSC cis rs7712401 0.755 rs4283786 chr5:122101050 T/C cg19077854 chr5:122220652 SNX24 0.35 7.77 0.39 9.65e-14 Mean platelet volume; LUSC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg10755058 chr3:40428713 ENTPD3 0.35 5.76 0.3 1.9e-8 Renal cell carcinoma; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg06873352 chr17:61820015 STRADA 0.71 12.72 0.57 1.68e-30 Prudent dietary pattern; LUSC cis rs9527 0.590 rs2182348 chr10:104872684 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg22467129 chr15:76604101 ETFA -0.51 -8.14 -0.41 8.05e-15 Blood metabolite levels; LUSC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs4474465 1.000 rs10793315 chr11:78190716 C/G cg27205649 chr11:78285834 NARS2 -0.49 -5.79 -0.3 1.62e-8 Alzheimer's disease (survival time); LUSC cis rs11048434 0.736 rs12423746 chr12:9113002 G/T cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.38e-10 Sjögren's syndrome; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg07507251 chr3:52567010 NT5DC2 0.37 6.79 0.35 5.22e-11 Bipolar disorder; LUSC cis rs829883 1.000 rs249839 chr12:98872364 T/C cg25150519 chr12:98850993 NA 0.65 10.19 0.49 2.13e-21 Colorectal adenoma (advanced); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18635552 chr5:3599719 IRX1 0.34 6.32 0.33 8.26e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11677416 1.000 rs1878318 chr2:113545185 A/G cg27083787 chr2:113543245 IL1A 0.47 7.39 0.37 1.17e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9788682 0.894 rs4461039 chr15:78817447 A/T cg06917634 chr15:78832804 PSMA4 0.59 7.32 0.37 1.9e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs909002 0.849 rs10753257 chr1:32086089 G/A cg01639898 chr1:32083012 HCRTR1 0.27 6.32 0.33 8.36e-10 Intelligence (multi-trait analysis); LUSC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12667521 chr19:29218732 NA 0.59 8.86 0.44 4.87e-17 Methadone dose in opioid dependence; LUSC cis rs1957429 0.808 rs1467573 chr14:65347583 T/C cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs9952991 0.941 rs2542149 chr18:12779018 G/A cg23598886 chr18:12777645 NA 0.65 6.6 0.34 1.61e-10 Inflammatory skin disease; LUSC cis rs4478858 0.647 rs11581476 chr1:31717675 C/T cg00250761 chr1:31883323 NA -0.34 -8.23 -0.41 4.26e-15 Alcohol dependence; LUSC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.85 10.95 0.51 4.87e-24 Gut microbiome composition (summer); LUSC trans rs2197308 0.740 rs10880619 chr12:37922720 T/C cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg24209194 chr3:40518798 ZNF619 0.49 6.53 0.34 2.48e-10 Renal cell carcinoma; LUSC trans rs1005277 0.579 rs2472174 chr10:38375382 A/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.64 -0.47 1.44e-19 Extrinsic epigenetic age acceleration; LUSC cis rs12493885 0.725 rs61791468 chr3:153739520 G/C cg17054900 chr3:154042577 DHX36 -0.7 -7.37 -0.37 1.33e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs889312 0.923 rs12697152 chr5:56025716 A/G cg18230493 chr5:56204884 C5orf35 0.39 5.76 0.3 1.92e-8 Breast cancer;Breast cancer (early onset); LUSC cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg26647111 chr11:31128758 NA -0.43 -6.13 -0.32 2.47e-9 Red blood cell count; LUSC cis rs983392 0.805 rs7933805 chr11:59967526 A/G cg24026212 chr11:59952134 MS4A6A -0.38 -6.54 -0.34 2.26e-10 Alzheimer's disease (late onset); LUSC cis rs709400 0.567 rs1961600 chr14:103862144 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.99 -0.31 5.41e-9 Body mass index; LUSC cis rs1832871 0.711 rs7770047 chr6:158685696 A/G cg07165851 chr6:158734300 TULP4 0.5 7.76 0.39 1.03e-13 Height; LUSC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11890956 chr21:40555474 PSMG1 -0.74 -11.32 -0.53 2.39e-25 Menarche (age at onset); LUSC cis rs2625529 0.824 rs4777470 chr15:72207518 T/A cg16672083 chr15:72433130 SENP8 -0.5 -7.35 -0.37 1.56e-12 Red blood cell count; LUSC cis rs6424115 1.000 rs7515969 chr1:24158398 G/A cg15997130 chr1:24165203 NA -0.56 -9.19 -0.45 4.43e-18 Immature fraction of reticulocytes; LUSC cis rs9952991 0.941 rs9952749 chr18:12780456 A/G cg23544223 chr18:12777786 NA 0.58 6.15 0.32 2.18e-9 Inflammatory skin disease; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg22166914 chr1:53195759 ZYG11B 0.47 7.49 0.38 6.33e-13 Monocyte count; LUSC cis rs11112613 0.762 rs17037308 chr12:105949847 T/G cg03607813 chr12:105948248 NA 0.82 12.44 0.56 1.96e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7937682 1.000 rs12363179 chr11:111568091 G/A cg19812747 chr11:111475976 SIK2 0.5 6.81 0.35 4.44e-11 Primary sclerosing cholangitis; LUSC trans rs17133449 0.718 rs1901635 chr10:4751773 C/T cg17844448 chr7:27782764 TAX1BP1 -0.36 -5.99 -0.31 5.3300000000000004e-09 Major depressive disorder; LUSC cis rs10761482 0.861 rs9988785 chr10:62108992 C/T cg18175470 chr10:62150864 ANK3 -0.49 -6.96 -0.36 1.84e-11 Schizophrenia; LUSC cis rs2976388 0.647 rs1048831 chr8:143781858 G/A cg17252645 chr8:143867129 LY6D 0.38 6.63 0.34 1.32e-10 Urinary tract infection frequency; LUSC cis rs3126085 0.935 rs6670717 chr1:152249956 T/C cg26876637 chr1:152193138 HRNR -0.44 -5.83 -0.3 1.3e-8 Atopic dermatitis; LUSC cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg12935359 chr14:103987150 CKB -0.52 -8.05 -0.4 1.51e-14 Body mass index; LUSC cis rs72781680 0.752 rs72796116 chr2:23913769 C/T cg20701182 chr2:24300061 SF3B14 0.74 7.3 0.37 2.15e-12 Lymphocyte counts; LUSC cis rs6582630 0.555 rs12828034 chr12:38274249 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.97 -0.36 1.68e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg13256891 chr4:100009986 ADH5 -0.43 -5.95 -0.31 6.78e-9 Alcohol dependence; LUSC cis rs11039131 0.629 rs67871383 chr11:47335838 T/C cg20135002 chr11:47629003 NA -0.4 -5.76 -0.3 1.92e-8 Schizophrenia; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg13395646 chr4:1353034 KIAA1530 0.59 9.03 0.44 1.44e-17 Obesity-related traits; LUSC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg13393036 chr8:95962371 TP53INP1 -0.46 -9.57 -0.46 2.49e-19 Type 2 diabetes; LUSC cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg10802521 chr3:52805072 NEK4 -0.54 -8.58 -0.42 3.61e-16 Bipolar disorder; LUSC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg20406979 chr6:167373233 NA 0.25 5.92 0.31 7.93e-9 Crohn's disease; LUSC cis rs977987 0.836 rs8055974 chr16:75470986 C/G cg03315344 chr16:75512273 CHST6 0.5 9.58 0.46 2.31e-19 Dupuytren's disease; LUSC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg06808227 chr14:105710500 BRF1 -0.64 -9.56 -0.46 2.57e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs9807841 0.592 rs11085743 chr19:10759442 G/A cg17710535 chr19:10819994 QTRT1 0.42 6.93 0.35 2.2e-11 Inflammatory skin disease; LUSC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg05347473 chr6:146136440 FBXO30 -0.47 -7.97 -0.4 2.61e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6062509 0.895 rs55946717 chr20:62363869 G/A cg01176363 chr20:62369445 LIME1 -0.46 -6.96 -0.36 1.84e-11 Prostate cancer; LUSC cis rs9733 0.650 rs12125672 chr1:150554470 A/T cg04414720 chr1:150670196 GOLPH3L -0.41 -6.27 -0.32 1.14e-9 Tonsillectomy; LUSC cis rs1215050 0.791 rs165250 chr4:98696259 G/A cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.31e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs590121 0.876 rs6704 chr11:75283653 C/A cg26104986 chr11:75275303 SERPINH1 -0.28 -5.77 -0.3 1.77e-8 Coronary artery disease; LUSC cis rs4974559 0.947 rs10006381 chr4:1359309 C/T cg02980000 chr4:1222292 CTBP1 0.79 7.51 0.38 5.37e-13 Systolic blood pressure; LUSC cis rs6456156 0.586 rs6909180 chr6:167460537 A/G cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg07741184 chr6:167504864 NA 0.38 6.76 0.35 6.04e-11 Crohn's disease; LUSC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg04450456 chr4:17643702 FAM184B 0.35 5.89 0.31 9.3e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs80264589 1 rs80264589 chr6:26927602 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.59 -5.79 -0.3 1.64e-8 Lung cancer;Intelligence (multi-trait analysis); LUSC cis rs9902453 0.904 rs12948898 chr17:28410324 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -10.89 -0.51 7.67e-24 Coffee consumption (cups per day); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18268492 chr10:99185986 PGAM1 -0.5 -6.63 -0.34 1.38e-10 Bipolar disorder and schizophrenia; LUSC trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.52 -7.46 -0.38 7.77e-13 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg14552801 chr7:65878734 NA 0.37 5.71 0.3 2.56e-8 Aortic root size; LUSC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg15839431 chr19:19639596 YJEFN3 -0.63 -7.1 -0.36 7.36e-12 Bipolar disorder; LUSC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.88 0.4 4.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg18404041 chr3:52824283 ITIH1 0.6 10.8 0.51 1.56e-23 Bipolar disorder; LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg01802117 chr1:53393560 SCP2 -0.39 -6.37 -0.33 6.1e-10 Monocyte count; LUSC cis rs7647973 0.925 rs9834003 chr3:49216472 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.47 6.98 0.36 1.58e-11 Menarche (age at onset); LUSC trans rs1994135 0.608 rs1482994 chr12:33713631 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.12 0.48 3.66e-21 Resting heart rate; LUSC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg03388025 chr16:89894329 SPIRE2 -0.34 -6.97 -0.36 1.65e-11 Vitiligo; LUSC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg11366901 chr6:160182831 ACAT2 0.93 12.87 0.58 4.58e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs6681460 1.000 rs1329978 chr1:67116231 C/T cg02459107 chr1:67143332 SGIP1 0.48 9.0 0.44 1.8e-17 Presence of antiphospholipid antibodies; LUSC cis rs4595586 0.545 rs12809435 chr12:39404341 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.28 -0.37 2.45e-12 Morning vs. evening chronotype; LUSC cis rs1559088 0.842 rs12977993 chr19:33580453 T/A cg17764715 chr19:33622953 WDR88 0.61 8.31 0.41 2.45e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg11062466 chr8:58055876 NA 0.47 5.72 0.3 2.39e-8 Developmental language disorder (linguistic errors); LUSC trans rs9929218 0.954 rs1981871 chr16:68819007 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.55 -0.53 3.33e-26 Colorectal cancer; LUSC cis rs8017423 0.874 rs2149656 chr14:90707508 A/C cg04374321 chr14:90722782 PSMC1 0.7 10.68 0.5 4.34e-23 Mortality in heart failure; LUSC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg18876405 chr7:65276391 NA 0.71 12.48 0.56 1.38e-29 Aortic root size; LUSC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg11279151 chr3:101281821 RG9MTD1 -0.4 -5.73 -0.3 2.28e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg18538332 chr22:24372958 LOC391322 -0.41 -7.57 -0.38 3.73e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg23649088 chr2:200775458 C2orf69 0.52 7.1 0.36 7.75e-12 Schizophrenia; LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg00814883 chr7:100076585 TSC22D4 -0.74 -10.09 -0.48 4.6e-21 Platelet count; LUSC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.27 -0.45 2.28e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg13683864 chr3:40499215 RPL14 -1.05 -19.5 -0.73 4.6e-57 Renal cell carcinoma; LUSC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.38 7.15 0.36 5.66e-12 Schizophrenia; LUSC cis rs10493773 0.775 rs12739713 chr1:86150378 C/T cg17807903 chr1:86174739 ZNHIT6 -0.44 -10.36 -0.49 5.29e-22 Urate levels in overweight individuals; LUSC cis rs7089973 0.646 rs35453961 chr10:116638166 T/C cg23260525 chr10:116636907 FAM160B1 0.42 8.54 0.42 4.79e-16 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6582630 0.623 rs12299293 chr12:38436288 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.19 -0.41 5.43e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg08847533 chr14:75593920 NEK9 0.8 13.95 0.61 3.72e-35 Height; LUSC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg09323728 chr8:95962352 TP53INP1 -0.31 -5.8 -0.3 1.52e-8 Type 2 diabetes; LUSC cis rs9303401 0.659 rs35539277 chr17:56853833 G/A cg25039879 chr17:56429692 SUPT4H1 0.7 9.23 0.45 3.21e-18 Cognitive test performance; LUSC cis rs13223928 0.621 rs4722438 chr7:3155813 A/G cg19214707 chr7:3157722 NA 0.42 8.68 0.43 1.73e-16 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs6500602 0.647 rs1659497 chr16:4594635 G/A cg08645402 chr16:4508243 NA -0.42 -6.9 -0.35 2.65e-11 Schizophrenia; LUSC cis rs1160297 0.576 rs12475542 chr2:53111504 A/G cg07782112 chr2:53107842 NA -0.37 -6.08 -0.32 3.26e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg19592336 chr6:28129416 ZNF389 -0.52 -7.12 -0.36 6.71e-12 Depression; LUSC trans rs7618501 0.602 rs10049087 chr3:50123417 A/G cg21659725 chr3:3221576 CRBN -0.65 -10.56 -0.5 1.07e-22 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.867 rs2245176 chr15:43750762 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs735539 0.521 rs2818991 chr13:21397196 A/G cg04906043 chr13:21280425 IL17D -0.39 -5.81 -0.3 1.44e-8 Dental caries; LUSC cis rs9393777 0.623 rs9358946 chr6:26478927 G/A cg12826209 chr6:26865740 GUSBL1 0.68 7.67 0.39 1.85e-13 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg26384229 chr12:38710491 ALG10B 0.87 14.03 0.61 1.77e-35 Bladder cancer; LUSC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg19077165 chr18:44547161 KATNAL2 -0.44 -6.38 -0.33 5.92e-10 Personality dimensions; LUSC cis rs7824557 0.767 rs7837036 chr8:11175489 A/G cg27411982 chr8:10470053 RP1L1 0.4 6.44 0.33 4.2e-10 Retinal vascular caliber; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg27094323 chr7:1216898 NA -0.45 -7.76 -0.39 1.07e-13 Longevity;Endometriosis; LUSC cis rs9303401 0.580 rs2013166 chr17:56637630 C/T cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs10484885 0.878 rs17506550 chr6:90508896 A/G cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.22 -0.41 4.65e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3091242 0.933 rs1534954 chr1:25761924 A/T cg20684491 chr1:25596433 NA 0.37 5.86 0.31 1.12e-8 Erythrocyte sedimentation rate; LUSC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg12826209 chr6:26865740 GUSBL1 -0.74 -8.93 -0.44 2.96e-17 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg04352962 chr1:209979756 IRF6 0.55 6.46 0.33 3.73e-10 Cleft lip with or without cleft palate; LUSC cis rs7923609 0.846 rs10740115 chr10:65094990 G/A cg01631684 chr10:65280961 REEP3 -0.41 -6.43 -0.33 4.53e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9815354 0.812 rs59583650 chr3:41809063 A/G cg03022575 chr3:42003672 ULK4 0.83 8.34 0.41 2.04e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg22166914 chr1:53195759 ZYG11B -0.55 -8.8 -0.43 7.56e-17 Monocyte count; LUSC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg18876405 chr7:65276391 NA 0.6 9.71 0.47 8.76e-20 Aortic root size; LUSC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg13531842 chr10:38383804 ZNF37A -0.46 -7.18 -0.37 4.53e-12 Extrinsic epigenetic age acceleration; LUSC cis rs2795502 0.882 rs2744093 chr10:43339243 A/G cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg17143192 chr8:8559678 CLDN23 0.63 8.99 0.44 1.82e-17 Obesity-related traits; LUSC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg17948913 chr5:572064 NA 0.37 5.65 0.3 3.38e-8 Lung disease severity in cystic fibrosis; LUSC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg14829155 chr15:31115871 NA -0.57 -7.95 -0.4 2.82e-14 Huntington's disease progression; LUSC cis rs4601821 1.000 rs877138 chr11:113256508 A/G cg14159747 chr11:113255604 NA -0.26 -6.12 -0.32 2.62e-9 Alcoholic chronic pancreatitis; LUSC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.68 -10.35 -0.49 5.96e-22 Hip circumference adjusted for BMI; LUSC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg10523679 chr1:76189770 ACADM -0.85 -11.36 -0.53 1.62e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2540226 0.627 rs2192686 chr2:39928722 A/G cg23576258 chr2:39999331 THUMPD2 0.35 5.94 0.31 7.14e-9 Personality dimensions; LUSC cis rs1775715 0.835 rs11008701 chr10:32241096 A/G cg18675610 chr10:32216311 ARHGAP12 0.27 5.71 0.3 2.55e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg23172400 chr8:95962367 TP53INP1 -0.47 -9.59 -0.46 2.13e-19 Type 2 diabetes; LUSC cis rs1178968 1.000 rs4717085 chr7:72764807 C/T cg25889504 chr7:72793014 NA 0.6 7.8 0.39 7.86e-14 Triglyceride levels; LUSC cis rs67311347 0.544 rs7644643 chr3:40350209 C/T cg13683864 chr3:40499215 RPL14 0.72 11.5 0.53 5.29e-26 Renal cell carcinoma; LUSC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg23158103 chr7:148848205 ZNF398 -0.44 -7.16 -0.36 5.14e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15084286 chr11:17036142 PLEKHA7 0.87 16.07 0.66 1.88e-43 Coronary artery disease; LUSC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg20891283 chr12:69753455 YEATS4 0.8 14.15 0.61 6.15e-36 Blood protein levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27360527 chr16:85722694 GINS2 -0.49 -6.06 -0.31 3.75e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg08219700 chr8:58056026 NA 0.57 6.78 0.35 5.49e-11 Developmental language disorder (linguistic errors); LUSC cis rs4950928 0.774 rs4950931 chr1:203164075 G/A cg17014757 chr1:203156097 CHI3L1 -0.43 -7.63 -0.39 2.46e-13 YKL-40 levels; LUSC cis rs1865760 0.566 rs9295688 chr6:26084217 G/A cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg07936489 chr17:37558343 FBXL20 -0.73 -10.13 -0.48 3.42e-21 Glomerular filtration rate (creatinine); LUSC cis rs12681287 0.547 rs9297921 chr8:87542286 C/T cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs921665 0.831 rs6548167 chr2:3181062 A/G cg16434511 chr2:3151078 NA -0.62 -6.74 -0.35 7.05e-11 World class endurance athleticism; LUSC cis rs6967385 0.867 rs2356167 chr7:12360805 T/C cg06484146 chr7:12443880 VWDE 0.4 5.91 0.31 8.3e-9 Response to taxane treatment (placlitaxel); LUSC trans rs3733585 0.631 rs4697924 chr4:10124239 A/G cg26043149 chr18:55253948 FECH -0.55 -7.88 -0.4 4.64e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg13397359 chr6:42928475 GNMT -0.39 -6.23 -0.32 1.44e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg23985595 chr17:80112537 CCDC57 0.31 5.84 0.3 1.23e-8 Life satisfaction; LUSC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -7.79 -0.39 8.68e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs61931739 0.500 rs11053212 chr12:34466116 T/G cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.3e-10 Morning vs. evening chronotype; LUSC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg14298792 chr15:30685198 CHRFAM7A 0.63 8.14 0.41 7.98e-15 Huntington's disease progression; LUSC cis rs6754311 0.773 rs4988226 chr2:136610598 A/G cg25344623 chr2:136566232 LCT 0.37 5.68 0.3 2.96e-8 Mosquito bite size; LUSC cis rs10992471 0.528 rs10115290 chr9:95195858 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.52 -0.34 2.54e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg08999081 chr20:33150536 PIGU 0.46 8.79 0.43 7.8e-17 Glomerular filtration rate (creatinine); LUSC cis rs2273669 0.588 rs2145767 chr6:109296185 C/T cg05315195 chr6:109294784 ARMC2 -0.59 -6.46 -0.33 3.8e-10 Prostate cancer; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.72 10.88 0.51 8.49e-24 Lymphocyte counts; LUSC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg17366294 chr4:99064904 C4orf37 0.53 8.62 0.43 2.75e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.641 rs10786732 chr10:104762535 T/C cg05855489 chr10:104503620 C10orf26 0.52 7.86 0.4 5.22e-14 Arsenic metabolism; LUSC cis rs10144321 1.000 rs28581530 chr14:100872263 C/T cg14882082 chr14:100845427 WDR25 0.42 7.88 0.4 4.69e-14 Menarche (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05712126 chr22:29601860 EMID1 -0.51 -6.83 -0.35 3.95e-11 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs1784581 1.000 rs1615717 chr6:162400612 C/T cg17173639 chr6:162384350 PARK2 -0.81 -14.73 -0.63 3.48e-38 Itch intensity from mosquito bite; LUSC cis rs3092073 0.617 rs3893276 chr20:44591089 G/C cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.38 -6.04 -0.31 4.04e-9 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg08968635 chr6:28129556 ZNF389 0.45 5.67 0.3 3.06e-8 Parkinson's disease; LUSC cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg23649088 chr2:200775458 C2orf69 -0.47 -6.31 -0.33 8.98e-10 Schizophrenia; LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.13 0.32 2.46e-9 Menopause (age at onset); LUSC cis rs6669072 0.565 rs66467457 chr1:91271406 C/T cg08895590 chr1:91227319 NA -0.27 -5.81 -0.3 1.48e-8 Cognitive function; LUSC cis rs7520050 0.807 rs4660312 chr1:46110572 A/G cg06784218 chr1:46089804 CCDC17 0.3 5.93 0.31 7.71e-9 Red blood cell count;Reticulocyte count; LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00694512 chr3:126423063 CHCHD6 -0.38 -5.95 -0.31 6.83e-9 Electrocardiographic conduction measures; LUSC trans rs208520 0.909 rs62414636 chr6:67015723 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 8.76 0.43 9.74e-17 Exhaled nitric oxide output; LUSC cis rs7520050 0.778 rs3014218 chr1:46026328 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.12 -0.32 2.66e-9 Red blood cell count;Reticulocyte count; LUSC cis rs7568458 0.846 rs6705839 chr2:85761279 A/T cg02493740 chr2:85810744 VAMP5 -0.38 -6.85 -0.35 3.65e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07167398 chr1:182808363 DHX9 -0.49 -7.46 -0.38 7.61e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg23093090 chr10:104574429 C10orf26 -0.37 -6.99 -0.36 1.52e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.66 14.83 0.63 1.47e-38 Hemoglobin concentration; LUSC cis rs12493885 0.585 rs10513453 chr3:153640591 G/A cg17054900 chr3:154042577 DHX36 -0.56 -5.94 -0.31 7.13e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg26677194 chr12:130822605 PIWIL1 0.6 8.96 0.44 2.29e-17 Menopause (age at onset); LUSC cis rs713587 0.571 rs2917916 chr2:25316336 A/C cg01884057 chr2:25150051 NA -0.26 -5.72 -0.3 2.31e-8 Body mass index in non-asthmatics; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg16132339 chr22:24313637 DDTL;DDT 0.41 6.57 0.34 1.93e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs34891900 0.507 rs5992088 chr22:18135912 C/T cg08824373 chr22:18117835 NA 0.38 5.98 0.31 5.73e-9 Sum neutrophil eosinophil counts; LUSC cis rs4964805 0.594 rs954920 chr12:104173310 A/T cg02344784 chr12:104178138 NT5DC3 0.37 5.9 0.31 8.72e-9 Attention deficit hyperactivity disorder; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg06873352 chr17:61820015 STRADA 0.71 12.65 0.57 3.08e-30 Prudent dietary pattern; LUSC cis rs35486314 1 rs35486314 chr1:150901861 A/AT cg04414720 chr1:150670196 GOLPH3L -0.43 -6.71 -0.34 8.58e-11 Monocyte chemoattractant protein-1 levels; LUSC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.66 0.47 1.26e-19 Height; LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg16405210 chr4:1374714 KIAA1530 0.78 12.97 0.58 1.89e-31 Longevity; LUSC cis rs1559088 0.501 rs35599132 chr19:33570554 G/A cg17764715 chr19:33622953 WDR88 0.59 6.61 0.34 1.55e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg08219700 chr8:58056026 NA 0.56 7.66 0.39 2.04e-13 Developmental language disorder (linguistic errors); LUSC cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.73e-15 Homoarginine levels; LUSC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.95 0.4 2.83e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs68170813 0.605 rs74632724 chr7:107136759 A/G cg02696742 chr7:106810147 HBP1 -0.67 -9.82 -0.47 3.74e-20 Coronary artery disease; LUSC cis rs3106136 0.967 rs2306802 chr4:95186055 A/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.16 -0.32 2.11e-9 Capecitabine sensitivity; LUSC cis rs17095355 1.000 rs4565840 chr10:111717140 A/G cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.66 -0.39 1.97e-13 Biliary atresia; LUSC cis rs10843647 1.000 rs4931280 chr12:30328012 A/G cg12718339 chr12:29936407 TMTC1 -0.35 -5.82 -0.3 1.41e-8 Glucose homeostasis traits; LUSC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.47 0.5 2.21e-22 Hip circumference adjusted for BMI; LUSC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg03060546 chr3:49711283 APEH 0.7 11.77 0.54 5.47e-27 Resting heart rate; LUSC cis rs977987 0.836 rs34673655 chr16:75323559 T/C cg04384234 chr16:75411784 CFDP1 -0.37 -5.98 -0.31 5.9e-9 Dupuytren's disease; LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.52 0.42 5.56e-16 Prudent dietary pattern; LUSC cis rs1799949 0.794 rs116409325 chr17:41445460 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.91 0.51 6.85e-24 Menopause (age at onset); LUSC cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg26384229 chr12:38710491 ALG10B 0.63 10.03 0.48 7.07e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg27094323 chr7:1216898 NA -0.37 -6.44 -0.33 4.14e-10 Longevity;Endometriosis; LUSC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg18827107 chr12:86230957 RASSF9 -0.46 -6.96 -0.36 1.81e-11 Major depressive disorder; LUSC cis rs8032315 0.965 rs1894400 chr15:91428955 C/T cg06330618 chr15:91428456 FES 0.29 6.08 0.32 3.38e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs3096299 0.685 rs4785568 chr16:89553707 A/G cg06640241 chr16:89574553 SPG7 0.92 17.33 0.69 1.86e-48 Multiple myeloma (IgH translocation); LUSC cis rs807669 0.903 rs1780640 chr22:19174597 C/T cg02655711 chr22:19163373 SLC25A1 0.91 17.84 0.7 1.74e-50 Metabolite levels; LUSC cis rs897984 0.553 rs2125293 chr16:30863875 T/C cg02466173 chr16:30829666 NA 0.55 9.18 0.45 4.72e-18 Dementia with Lewy bodies; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07098151 chr1:229762071 URB2;TAF5L 0.41 6.97 0.36 1.74e-11 Triglycerides; LUSC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs8062405 0.964 rs62036614 chr16:28824685 T/C cg05966235 chr16:28915196 ATP2A1 0.33 5.8 0.3 1.56e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18238734 chr12:26986119 ITPR2 0.47 6.91 0.35 2.46e-11 Triglycerides; LUSC cis rs9513627 0.749 rs73556143 chr13:100116907 G/A cg25919922 chr13:100150906 NA -0.74 -6.22 -0.32 1.52e-9 Obesity-related traits; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg13560548 chr3:10150139 C3orf24 0.48 7.13 0.36 6.15e-12 Alzheimer's disease; LUSC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg16624210 chr5:671434 TPPP 0.5 6.38 0.33 6.07e-10 Lung disease severity in cystic fibrosis; LUSC cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs250677 1.000 rs250677 chr5:148433549 T/C cg05026186 chr5:148520876 ABLIM3 -0.39 -6.14 -0.32 2.34e-9 Breast cancer; LUSC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg26566898 chr11:117069891 TAGLN 0.49 8.97 0.44 2.16e-17 Blood protein levels; LUSC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg25456477 chr12:86230367 RASSF9 0.33 5.71 0.3 2.53e-8 Major depressive disorder; LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.14 0.41 7.76e-15 Bipolar disorder; LUSC cis rs4363385 0.510 rs7543689 chr1:153046803 A/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.23 -0.32 1.43e-9 Inflammatory skin disease; LUSC cis rs2404602 0.692 rs8037005 chr15:76951109 C/T cg22467129 chr15:76604101 ETFA -0.43 -6.85 -0.35 3.46e-11 Blood metabolite levels; LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg14092988 chr3:52407081 DNAH1 0.31 5.97 0.31 5.97e-9 Bipolar disorder; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg18765753 chr7:1198926 ZFAND2A 0.46 8.24 0.41 3.98e-15 Longevity;Endometriosis; LUSC cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg24642439 chr20:33292090 TP53INP2 0.5 7.48 0.38 6.55e-13 Height; LUSC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg02487422 chr3:49467188 NICN1 0.48 7.63 0.39 2.46e-13 Resting heart rate; LUSC cis rs9790314 0.905 rs4856739 chr3:160986710 A/C cg03342759 chr3:160939853 NMD3 -0.52 -8.74 -0.43 1.16e-16 Morning vs. evening chronotype; LUSC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg12564285 chr5:131593104 PDLIM4 0.35 6.47 0.33 3.46e-10 Blood metabolite levels; LUSC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg17294928 chr15:75287854 SCAMP5 -0.77 -10.2 -0.49 1.91e-21 Blood trace element (Zn levels); LUSC cis rs4900538 0.819 rs72700604 chr14:102882307 G/A cg18135206 chr14:102964638 TECPR2 -1.0 -18.99 -0.72 4.7e-55 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg19622623 chr12:86230825 RASSF9 0.4 5.84 0.3 1.21e-8 Major depressive disorder; LUSC cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Bladder cancer; LUSC cis rs2963155 1.000 rs2963155 chr5:142756004 C/T cg17617527 chr5:142782415 NR3C1 -0.49 -7.09 -0.36 8.17e-12 Breast cancer; LUSC cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg13010199 chr12:38710504 ALG10B 0.66 10.18 0.49 2.18e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs79349575 0.783 rs962272 chr17:46978283 A/G cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs17604090 0.887 rs7795109 chr7:29666244 G/A cg19413766 chr7:29689036 LOC646762 -0.62 -7.77 -0.39 9.47e-14 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg24739457 chr1:205821442 NA 0.35 6.02 0.31 4.47e-9 Menarche (age at onset); LUSC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg26513180 chr16:89883248 FANCA 0.9 17.31 0.69 2.23e-48 Vitiligo; LUSC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg21724239 chr8:58056113 NA 0.57 6.53 0.34 2.39e-10 Developmental language disorder (linguistic errors); LUSC cis rs4730250 0.669 rs6466160 chr7:106793175 T/A cg02696742 chr7:106810147 HBP1 0.64 9.04 0.44 1.32e-17 Osteoarthritis; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg02475777 chr4:1388615 CRIPAK -0.41 -6.08 -0.32 3.34e-9 Obesity-related traits; LUSC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg07636037 chr3:49044803 WDR6 0.45 6.4 0.33 5.13e-10 Resting heart rate; LUSC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs765787 0.530 rs12915804 chr15:45512562 T/C cg25801113 chr15:45476975 SHF -0.32 -6.43 -0.33 4.34e-10 Uric acid levels; LUSC cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.25 0.52 4.04e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7264396 0.563 rs2425132 chr20:34338390 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.71 -0.43 1.46e-16 Total cholesterol levels; LUSC trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs523522 0.962 rs509445 chr12:121017243 A/C cg27279351 chr12:120934652 DYNLL1 0.65 8.81 0.43 6.91e-17 High light scatter reticulocyte count; LUSC trans rs7951105 0.867 rs12287031 chr11:39257902 A/G cg24085930 chr3:21832523 NA 0.48 6.02 0.31 4.72e-9 Free thyroxine concentration; LUSC cis rs9398803 0.865 rs9385401 chr6:126789472 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.19 0.32 1.78e-9 Male-pattern baldness; LUSC cis rs865483 0.895 rs1016678 chr17:35874192 A/G cg06716730 chr17:35851459 DUSP14 0.26 5.74 0.3 2.09e-8 Monocyte count; LUSC cis rs7789940 1.000 rs73140069 chr7:75986790 T/A cg10167463 chr7:75959203 YWHAG -0.66 -10.07 -0.48 5.33e-21 Multiple sclerosis; LUSC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg05623727 chr3:50126028 RBM5 -0.33 -6.17 -0.32 1.99e-9 Intelligence (multi-trait analysis); LUSC cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg24812749 chr6:127587940 RNF146 0.7 9.92 0.48 1.75e-20 Breast cancer; LUSC cis rs7829975 0.577 rs940032 chr8:8546343 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.42 -0.38 9.85e-13 Mood instability; LUSC cis rs6430585 0.528 rs7573555 chr2:136694905 C/T cg07169764 chr2:136633963 MCM6 -1.13 -18.66 -0.71 1.01e-53 Corneal structure; LUSC cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg03146154 chr1:46216737 IPP 0.56 8.5 0.42 6.44e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1728785 0.901 rs11865339 chr16:68565296 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs6121246 0.567 rs6060297 chr20:30198560 A/G cg13852791 chr20:30311386 BCL2L1 0.75 8.59 0.43 3.47e-16 Mean corpuscular hemoglobin; LUSC trans rs7715474 0.656 rs7734839 chr5:120079467 T/C cg12284098 chr8:1993893 MYOM2 0.32 5.99 0.31 5.3300000000000004e-09 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg09998033 chr7:158218633 PTPRN2 -0.6 -9.56 -0.46 2.64e-19 Obesity-related traits; LUSC cis rs11645898 0.935 rs17603936 chr16:72169002 C/A cg14768367 chr16:72042858 DHODH -0.65 -7.11 -0.36 7.28e-12 Blood protein levels; LUSC cis rs10761482 0.906 rs2219534 chr10:62094925 G/A cg18175470 chr10:62150864 ANK3 -0.45 -6.57 -0.34 1.95e-10 Schizophrenia; LUSC cis rs7771547 0.519 rs12190911 chr6:36378487 C/T cg07856975 chr6:36356162 ETV7 -0.42 -6.37 -0.33 6.21e-10 Platelet distribution width; LUSC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg05043794 chr9:111880884 C9orf5 -0.39 -8.23 -0.41 4.14e-15 Menarche (age at onset); LUSC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg06618935 chr21:46677482 NA -0.4 -8.06 -0.4 1.41e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6747952 0.866 rs6726348 chr2:239084119 C/T cg17459225 chr2:239074497 NA 0.33 5.77 0.3 1.83e-8 Mean corpuscular hemoglobin concentration; LUSC cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg05283184 chr6:79620031 NA -0.57 -11.95 -0.55 1.16e-27 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg13939156 chr17:80058883 NA 0.34 6.67 0.34 1.09e-10 Life satisfaction; LUSC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.23e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.05 -0.36 1.03e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7481584 0.517 rs80872 chr11:3049984 G/T cg25174290 chr11:3078921 CARS -0.42 -6.16 -0.32 2.11e-9 Calcium levels; LUSC cis rs727505 0.908 rs56155943 chr7:124606346 T/G cg23710748 chr7:124431027 NA -0.39 -6.83 -0.35 4e-11 Lewy body disease; LUSC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg18681998 chr4:17616180 MED28 0.83 15.51 0.65 2.97e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10892173 0.566 rs10892175 chr11:117674355 G/A cg04064380 chr11:117688259 NA -0.43 -5.66 -0.3 3.25e-8 Myopia; LUSC cis rs4900538 0.821 rs2009575 chr14:102820787 C/T cg18135206 chr14:102964638 TECPR2 -0.99 -18.53 -0.71 3.22e-53 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs16976116 0.803 rs28590021 chr15:55490993 C/T cg11288833 chr15:55489084 RSL24D1 0.5 5.98 0.31 5.65e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7940866 0.834 rs7939417 chr11:130853832 T/A cg12179176 chr11:130786555 SNX19 0.59 8.9 0.44 3.7e-17 Schizophrenia; LUSC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.93e-11 Blood metabolite levels; LUSC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg13798780 chr7:105162888 PUS7 0.56 6.12 0.32 2.55e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7106204 0.534 rs4923167 chr11:24274441 G/T ch.11.24196551F chr11:24239977 NA 0.72 5.91 0.31 8.23e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs72781680 1.000 rs7594510 chr2:24173377 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg05340658 chr4:99064831 C4orf37 0.66 11.24 0.52 4.38e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs73058052 0.935 rs3745473 chr19:50086626 T/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.5 5.8 0.3 1.56e-8 Fibrinogen levels; LUSC trans rs9291683 0.551 rs2240720 chr4:10020480 C/T cg26043149 chr18:55253948 FECH 0.5 7.45 0.38 8.1e-13 Bone mineral density; LUSC trans rs2832077 0.943 rs4816332 chr21:30201706 T/C cg14791747 chr16:20752902 THUMPD1 0.72 9.58 0.46 2.35e-19 Cognitive test performance; LUSC cis rs5771069 0.931 rs137864 chr22:50446988 C/T cg27467552 chr22:50353597 PIM3 -0.43 -7.17 -0.37 4.84e-12 Ulcerative colitis; LUSC cis rs13401104 0.754 rs10929175 chr2:237117204 A/C cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg17330251 chr7:94953956 PON1 -0.36 -5.84 -0.3 1.22e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs7746199 0.736 rs13209332 chr6:27520752 T/A cg01620082 chr3:125678407 NA -0.72 -6.85 -0.35 3.64e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs503341 0.756 rs626333 chr11:63591861 C/T cg04362095 chr11:63592001 C11orf84 -0.55 -8.53 -0.42 5.18e-16 Pulse pressure; LUSC cis rs6700896 0.500 rs6690625 chr1:66077590 T/G cg14976592 chr1:65886160 LEPROT;LEPR 0.51 6.03 0.31 4.42e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7216064 0.953 rs75231441 chr17:65885485 A/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2996428 0.667 rs11578581 chr1:3770642 G/A cg17848003 chr1:3704513 LRRC47 0.32 5.83 0.3 1.32e-8 Red cell distribution width; LUSC cis rs9486715 0.830 rs1475748 chr6:97034143 T/C cg06623918 chr6:96969491 KIAA0776 -0.94 -18.4 -0.71 1.04e-52 Headache; LUSC cis rs10197940 0.624 rs4461258 chr2:152429679 A/G cg19508488 chr2:152266495 RIF1 -0.52 -7.36 -0.37 1.46e-12 Lung cancer; LUSC cis rs4853525 0.923 rs7570775 chr2:191729154 T/G cg11845111 chr2:191398756 TMEM194B -0.39 -5.76 -0.3 1.87e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC trans rs11743006 0.626 rs1072158 chr5:136504666 A/C cg07379741 chr17:7311030 NLGN2 0.42 6.34 0.33 7.6e-10 Mathematical ability; LUSC cis rs4595586 0.545 rs7972590 chr12:39376615 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 11.83 0.54 3.45e-27 Colorectal cancer; LUSC cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg14895029 chr7:2775587 GNA12 -0.42 -6.55 -0.34 2.18e-10 Height; LUSC cis rs72960926 0.744 rs72950506 chr6:74895922 A/G cg03266952 chr6:74778945 NA -0.76 -6.05 -0.31 3.85e-9 Metabolite levels (MHPG); LUSC cis rs1448094 0.935 rs11117120 chr12:86336447 G/A cg00310523 chr12:86230176 RASSF9 0.4 7.31 0.37 1.94e-12 Major depressive disorder; LUSC cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC trans rs2797160 1.000 rs2797154 chr6:126005197 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.16e-10 Endometrial cancer; LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg12432903 chr7:1882776 MAD1L1 -0.37 -5.89 -0.31 9.45e-9 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg21770322 chr7:97807741 LMTK2 0.39 6.89 0.35 2.72e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs433852 0.718 rs386551 chr19:49138286 C/G cg06530960 chr19:49140787 SEC1;DBP -0.55 -7.57 -0.38 3.76e-13 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7927592 0.913 rs7123564 chr11:68362164 C/T cg20283391 chr11:68216788 NA -0.61 -8.43 -0.42 1.04e-15 Total body bone mineral density; LUSC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg12463550 chr7:65579703 CRCP 0.45 6.62 0.34 1.44e-10 Aortic root size; LUSC trans rs7819412 0.775 rs2001329 chr8:10986859 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.75 -0.35 6.42e-11 Triglycerides; LUSC cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg22117172 chr7:91764530 CYP51A1 -0.33 -5.93 -0.31 7.65e-9 Breast cancer; LUSC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg09267113 chr7:98030324 BAIAP2L1 0.39 5.92 0.31 7.89e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs17301259 0.729 rs2718396 chr7:88377422 T/A cg21771463 chr3:44626400 ZNF660 -0.39 -6.21 -0.32 1.62e-9 Heschl's gyrus morphology; LUSC cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg15423357 chr2:25149977 NA 0.4 7.74 0.39 1.16e-13 Body mass index in non-asthmatics; LUSC cis rs7772486 0.875 rs864390 chr6:146315035 G/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.92 -0.35 2.29e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs11608355 0.508 rs11066411 chr12:109804194 A/G cg19025524 chr12:109796872 NA -0.5 -8.86 -0.44 4.73e-17 Neuroticism; LUSC cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg13319975 chr6:146136371 FBXO30 0.45 6.8 0.35 4.81e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.967 rs1577924 chr20:33784288 C/G cg07148914 chr20:33460835 GGT7 -0.44 -6.63 -0.34 1.35e-10 Height; LUSC cis rs7246967 0.673 rs12984634 chr19:22833744 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs7607369 0.559 rs4674343 chr2:219660346 C/T cg02176678 chr2:219576539 TTLL4 0.53 9.4 0.46 9.25e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs8072100 0.817 rs9892497 chr17:45545919 G/A cg04995722 chr7:26192034 NFE2L3 -0.43 -6.71 -0.34 8.55e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg18225595 chr11:63971243 STIP1 0.49 6.1 0.32 2.88e-9 Mean platelet volume; LUSC trans rs12579753 0.879 rs11615729 chr12:82128318 T/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.64 -0.34 1.24e-10 Resting heart rate; LUSC cis rs7481584 0.624 rs369461 chr11:3061992 A/G cg25174290 chr11:3078921 CARS -0.4 -5.88 -0.31 9.72e-9 Calcium levels; LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.14e-9 Menopause (age at onset); LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg07507251 chr3:52567010 NT5DC2 0.37 7.53 0.38 4.66e-13 Electroencephalogram traits; LUSC trans rs57221529 0.766 rs56278696 chr5:582669 A/G cg25482853 chr8:67687455 SGK3 1.18 16.97 0.68 5.1e-47 Lung disease severity in cystic fibrosis; LUSC cis rs1371867 0.875 rs1371868 chr8:101330267 C/T cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg05585544 chr11:47624801 NA -0.36 -6.55 -0.34 2.2e-10 Subjective well-being; LUSC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg08270630 chr22:50330655 NA -0.44 -6.67 -0.34 1.05e-10 Schizophrenia; LUSC trans rs10506458 0.915 rs1009540 chr12:63414872 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -15.94 -0.66 6.41e-43 Hemostatic factors and hematological phenotypes; LUSC cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg05347473 chr6:146136440 FBXO30 0.49 8.16 0.41 6.84e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs1371867 0.846 rs1788167 chr8:101319996 C/T cg00191853 chr8:101177733 SPAG1 -0.38 -6.41 -0.33 4.87e-10 Atrioventricular conduction; LUSC cis rs72615157 0.539 rs4729575 chr7:99686873 G/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.48 6.6 0.34 1.61e-10 Lung function (FEV1/FVC); LUSC cis rs1983170 0.808 rs1546449 chr1:92017391 G/A cg25838465 chr1:92012736 NA 0.43 5.96 0.31 6.48e-9 Eosinophil percentage of white cells; LUSC trans rs61931739 0.500 rs11053197 chr12:34441949 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.81 0.51 1.43e-23 Morning vs. evening chronotype; LUSC cis rs977987 0.843 rs35737321 chr16:75439185 A/T cg04384234 chr16:75411784 CFDP1 -0.44 -7.05 -0.36 1.03e-11 Dupuytren's disease; LUSC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg09085632 chr11:111637200 PPP2R1B 0.96 13.66 0.6 4.88e-34 Primary sclerosing cholangitis; LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg24675658 chr1:53192096 ZYG11B 0.61 9.64 0.47 1.5e-19 Monocyte count; LUSC cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg01579765 chr21:45077557 HSF2BP 0.42 8.7 0.43 1.49e-16 Mean corpuscular volume; LUSC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg07936489 chr17:37558343 FBXL20 -0.71 -10.09 -0.48 4.59e-21 Glomerular filtration rate (creatinine); LUSC trans rs3749237 1.000 rs11130214 chr3:49735746 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -7.18 -0.37 4.68e-12 Resting heart rate; LUSC cis rs6084875 0.840 rs2025118 chr20:4723691 C/T cg07258627 chr20:4721683 PRNT -0.35 -6.21 -0.32 1.57e-9 Systemic lupus erythematosus; LUSC trans rs4714291 0.963 rs4714292 chr6:40003679 A/C cg02267698 chr19:7991119 CTXN1 0.47 6.66 0.34 1.15e-10 Strep throat; LUSC cis rs4588572 0.643 rs1560197 chr5:77768302 T/C cg11547950 chr5:77652471 NA -0.52 -7.52 -0.38 5.01e-13 Triglycerides; LUSC cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg09699651 chr6:150184138 LRP11 0.43 6.28 0.33 1.04e-9 Testicular germ cell tumor; LUSC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg16447950 chr5:562315 NA -0.55 -7.67 -0.39 1.88e-13 Lung disease severity in cystic fibrosis; LUSC cis rs870825 0.581 rs28602720 chr4:185630598 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.06 0.58 8.67e-32 Blood protein levels; LUSC cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.51e-15 Chronic sinus infection; LUSC cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg02475777 chr4:1388615 CRIPAK 0.4 6.07 0.32 3.53e-9 Obesity-related traits; LUSC trans rs853679 0.517 rs9380058 chr6:28127444 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.21 -0.32 1.57e-9 Depression; LUSC cis rs4566357 0.964 rs6436648 chr2:227923004 C/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg24549020 chr5:56110836 MAP3K1 0.48 5.66 0.3 3.3e-8 Initial pursuit acceleration; LUSC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg08439880 chr3:133502540 NA -0.34 -6.08 -0.32 3.32e-9 Iron status biomarkers; LUSC cis rs1348850 0.554 rs7595576 chr2:178371921 C/T cg22681709 chr2:178499509 PDE11A -0.45 -6.65 -0.34 1.19e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs782590 0.537 rs7575170 chr2:55886780 C/T cg18811423 chr2:55921094 PNPT1 -0.63 -8.56 -0.42 4.12e-16 Metabolic syndrome; LUSC cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs4700695 0.719 rs27586 chr5:65445873 G/A cg21114390 chr5:65439923 SFRS12 -0.64 -9.12 -0.45 7.01e-18 Facial morphology (factor 19); LUSC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg21862992 chr11:68658383 NA -0.51 -8.29 -0.41 2.89e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6460942 0.908 rs6978367 chr7:12232347 A/G cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg27633287 chr12:130766243 NA 0.32 5.74 0.3 2.11e-8 Menopause (age at onset); LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13275176 chr2:97534450 SEMA4C 0.5 6.11 0.32 2.79e-9 Intelligence (multi-trait analysis); LUSC cis rs7681440 0.904 rs7698219 chr4:90771351 C/A cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.3 1.17e-8 Dementia with Lewy bodies; LUSC cis rs1256061 0.646 rs1256059 chr14:64710417 A/G cg23250157 chr14:64679961 SYNE2 0.32 5.82 0.3 1.37e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9814567 1.000 rs1357762 chr3:134264859 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.25 -0.59 1.75e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg05283184 chr6:79620031 NA -0.58 -12.14 -0.55 2.34e-28 Intelligence (multi-trait analysis); LUSC cis rs6762 0.719 rs4895 chr11:840477 A/G cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.93 -0.35 2.16e-11 Mean platelet volume; LUSC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg24154853 chr7:158122151 PTPRN2 -0.42 -8.19 -0.41 5.57e-15 Calcium levels; LUSC cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg18681998 chr4:17616180 MED28 0.85 15.66 0.65 8.11e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs41271473 0.526 rs10916344 chr1:228737489 C/T cg16512390 chr1:228756714 NA 0.73 9.67 0.47 1.19e-19 Chronic lymphocytic leukemia; LUSC cis rs5769707 0.681 rs6009803 chr22:50051007 A/G cg05373962 chr22:49881684 NA -0.4 -8.25 -0.41 3.6e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg11416102 chr8:651193 ERICH1 -0.75 -6.76 -0.35 6.2e-11 IgG glycosylation; LUSC cis rs1008375 0.835 rs9760627 chr4:17651508 C/T cg18681998 chr4:17616180 MED28 0.87 16.62 0.67 1.22e-45 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg09365446 chr1:150670422 GOLPH3L -0.43 -6.46 -0.33 3.79e-10 Tonsillectomy; LUSC trans rs4664304 0.629 rs3828324 chr2:160834991 C/T cg05371993 chr16:1458494 UNKL -0.41 -6.07 -0.32 3.57e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.62 0.54 1.85e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1348850 0.561 rs1838890 chr2:178410938 C/A cg22681709 chr2:178499509 PDE11A -0.44 -6.51 -0.34 2.81e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg18758796 chr5:131593413 PDLIM4 0.42 6.74 0.35 6.97e-11 Breast cancer; LUSC cis rs1953600 0.870 rs2573353 chr10:81940917 A/C cg00277334 chr10:82204260 NA -0.46 -7.27 -0.37 2.63e-12 Sarcoidosis; LUSC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg08270630 chr22:50330655 NA 0.4 5.9 0.31 9.13e-9 Schizophrenia; LUSC cis rs1577917 1.000 rs13199006 chr6:86608708 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC trans rs10851478 0.872 rs12902960 chr15:49925041 T/C cg23074453 chr15:44487924 FRMD5 -0.33 -6.08 -0.32 3.26e-9 Oral cavity cancer; LUSC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.87 -0.35 3.23e-11 Menopause (age at onset); LUSC trans rs7937682 0.883 rs490492 chr11:111465150 C/T cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg00321850 chr1:175162397 KIAA0040 -0.45 -7.81 -0.39 7.35e-14 Alcohol dependence; LUSC cis rs897984 0.647 rs7203999 chr16:31017554 T/C cg02466173 chr16:30829666 NA 0.54 10.27 0.49 1.07e-21 Dementia with Lewy bodies; LUSC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -6.06 -0.31 3.7e-9 Personality dimensions; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.73 -0.39 1.26e-13 Lymphocyte counts; LUSC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg13902645 chr11:5959945 NA -0.55 -8.6 -0.43 3.15e-16 DNA methylation (variation); LUSC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.27 -0.32 1.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs5167 0.566 rs934427 chr19:45478816 T/G cg25746394 chr19:45450501 APOC2 0.31 5.87 0.31 1.03e-8 Blood protein levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07940793 chr17:79603854 NPLOC4 -0.47 -6.42 -0.33 4.59e-10 Bipolar disorder and schizophrenia; LUSC cis rs12474201 0.619 rs17821827 chr2:46918682 C/T cg06386533 chr2:46925753 SOCS5 0.64 7.81 0.39 7.65e-14 Height; LUSC cis rs2050392 0.517 rs619864 chr10:30750950 A/G cg18806716 chr10:30721971 MAP3K8 0.62 10.24 0.49 1.45e-21 Inflammatory bowel disease; LUSC cis rs2857891 0.817 rs2638096 chr11:6977916 T/A cg04053776 chr11:6947353 ZNF215 0.42 5.76 0.3 1.94e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs9300255 0.602 rs1716165 chr12:123648881 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.14 -0.32 2.38e-9 Neutrophil percentage of white cells; LUSC cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.45 5.76 0.3 1.93e-8 Renal function-related traits (BUN); LUSC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg06028605 chr16:24865363 SLC5A11 0.66 9.99 0.48 9.87e-21 Intelligence (multi-trait analysis); LUSC cis rs56104184 0.779 rs17272666 chr19:49356294 T/C cg15549821 chr19:49342101 PLEKHA4 -0.89 -11.16 -0.52 8.48e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs2506889 0.553 rs11580264 chr1:10605796 C/A cg17425144 chr1:10567563 PEX14 0.64 13.54 0.6 1.36e-33 Breast cancer; LUSC cis rs4072705 0.967 rs4287038 chr9:127369679 A/G cg13476313 chr9:127244764 NR5A1 -0.29 -5.71 -0.3 2.5e-8 Menarche (age at onset); LUSC cis rs9393777 0.623 rs9358944 chr6:26469875 A/C cg12826209 chr6:26865740 GUSBL1 0.68 7.53 0.38 4.76e-13 Intelligence (multi-trait analysis); LUSC cis rs1372520 0.873 rs2736989 chr4:90776257 T/C cg15133208 chr4:90757351 SNCA -0.53 -8.19 -0.41 5.6e-15 Neuroticism; LUSC cis rs34233420 1 rs34233420 chr17:38004929 GATTT/G cg19468946 chr17:37922297 IKZF3 -0.44 -6.87 -0.35 3.1e-11 Lymphocyte counts; LUSC trans rs1908814 0.516 rs11250178 chr8:11800234 A/C cg06636001 chr8:8085503 FLJ10661 0.54 7.93 0.4 3.32e-14 Neuroticism; LUSC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg21918786 chr6:109611834 NA -0.39 -6.77 -0.35 5.66e-11 Reticulocyte fraction of red cells; LUSC trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg15704280 chr7:45808275 SEPT13 -0.46 -6.34 -0.33 7.57e-10 HDL cholesterol; LUSC cis rs7833986 0.501 rs72653953 chr8:56970795 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.53 0.57 8.96e-30 Height; LUSC trans rs2392780 0.536 rs377649 chr8:128337241 G/T cg10195415 chr17:73887371 TRIM65 0.42 6.67 0.34 1.08e-10 Breast cancer (early onset); LUSC cis rs7089973 0.604 rs7903663 chr10:116609904 G/A cg25233709 chr10:116636983 FAM160B1 0.37 6.56 0.34 2.09e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs12412942 1.000 rs12412942 chr10:2357702 C/T cg08626939 chr2:227656417 IRS1 0.39 5.95 0.31 6.96e-9 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25261764 chr18:55288998 NARS 0.41 6.55 0.34 2.19e-10 Triglycerides; LUSC cis rs1891275 0.515 rs7092745 chr10:93483820 C/T cg07889827 chr10:93443413 NA -0.39 -8.93 -0.44 2.81e-17 Intelligence (multi-trait analysis); LUSC cis rs1003719 0.646 rs9985082 chr21:38501021 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs992157 1.000 rs736731 chr2:219120588 A/G cg00012203 chr2:219082015 ARPC2 0.81 13.69 0.6 3.57e-34 Colorectal cancer; LUSC cis rs34779708 0.900 rs73262807 chr10:35496386 C/T cg03585969 chr10:35415529 CREM 0.64 9.51 0.46 4e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10144321 0.810 rs3742387 chr14:100847930 C/T cg14882082 chr14:100845427 WDR25 -0.41 -7.92 -0.4 3.63e-14 Menarche (age at onset); LUSC cis rs701145 0.585 rs1727953 chr3:153871392 G/T cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs8060686 0.545 rs76495028 chr16:68177036 G/C cg05110241 chr16:68378359 PRMT7 -0.65 -6.79 -0.35 5.13e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs6785206 1.000 rs6785206 chr3:128412024 A/G cg16766828 chr3:128327626 NA -0.69 -7.64 -0.39 2.34e-13 Lymphocyte percentage of white cells; LUSC cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs10751667 0.666 rs10902235 chr11:938892 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.4 0.33 5.33e-10 Alzheimer's disease (late onset); LUSC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.09e-11 Intelligence (multi-trait analysis); LUSC cis rs73200209 0.744 rs56911341 chr12:116682872 A/C cg01776926 chr12:116560359 MED13L -0.49 -5.98 -0.31 5.81e-9 Total body bone mineral density; LUSC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg04352962 chr1:209979756 IRF6 0.52 5.77 0.3 1.83e-8 Coronary artery disease; LUSC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg09455208 chr3:40491958 NA 0.57 10.34 0.49 6.55e-22 Renal cell carcinoma; LUSC cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.56 -0.38 3.87e-13 Personality dimensions; LUSC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.24 -0.41 3.91e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs6840360 0.806 rs11932383 chr4:152716136 T/C cg22705602 chr4:152727874 NA 0.27 5.73 0.3 2.24e-8 Intelligence (multi-trait analysis); LUSC cis rs2200578 1.000 rs2200578 chr2:99876244 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.57 6.55 0.34 2.16e-10 IgG glycosylation; LUSC cis rs2204008 0.582 rs11179135 chr12:38204689 A/C cg26384229 chr12:38710491 ALG10B 0.93 15.61 0.65 1.21e-41 Bladder cancer; LUSC cis rs16867335 1.000 rs76934807 chr2:181488585 T/A cg23363182 chr2:181467187 NA -0.47 -5.92 -0.31 7.92e-9 Survival in rectal cancer; LUSC trans rs4689592 0.513 rs2358718 chr4:7068743 A/C cg07817883 chr1:32538562 TMEM39B 0.56 6.55 0.34 2.17e-10 Monocyte percentage of white cells; LUSC cis rs12541635 0.966 rs7812766 chr8:107057033 G/A cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.69e-20 Age of smoking initiation; LUSC cis rs9790314 1.000 rs336583 chr3:161081981 A/T cg04691961 chr3:161091175 C3orf57 0.34 5.86 0.31 1.12e-8 Morning vs. evening chronotype; LUSC cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg15691649 chr6:25882328 NA -0.39 -6.41 -0.33 4.84e-10 Blood metabolite levels; LUSC cis rs977987 0.806 rs34996006 chr16:75479434 A/G cg03315344 chr16:75512273 CHST6 0.5 9.67 0.47 1.17e-19 Dupuytren's disease; LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs2760061 0.505 rs708109 chr1:228190657 C/T cg18477163 chr1:228402036 OBSCN 0.57 9.59 0.46 2.12e-19 Diastolic blood pressure; LUSC trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg08975724 chr8:8085496 FLJ10661 -0.48 -7.1 -0.36 7.33e-12 Myopia (pathological); LUSC cis rs28374715 0.580 rs8030228 chr15:41636867 A/G cg18705301 chr15:41695430 NDUFAF1 -0.99 -20.86 -0.75 1.83e-62 Ulcerative colitis; LUSC cis rs9457247 0.566 rs10946207 chr6:167456036 C/T cg25258033 chr6:167368657 RNASET2 0.42 6.37 0.33 6.09e-10 Crohn's disease; LUSC cis rs7095944 0.644 rs4962694 chr10:126436717 G/T cg08799069 chr10:126477246 METTL10 -0.41 -6.27 -0.32 1.12e-9 Asthma; LUSC cis rs225245 0.791 rs3890901 chr17:34011322 A/C cg05299278 chr17:33885742 SLFN14 0.29 6.33 0.33 7.72e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs62400317 0.762 rs72865923 chr6:44878942 T/G cg20913747 chr6:44695427 NA -0.48 -7.44 -0.38 8.79e-13 Total body bone mineral density; LUSC cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg04362960 chr10:104952993 NT5C2 0.62 9.8 0.47 4.43e-20 Arsenic metabolism; LUSC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg22920501 chr2:26401640 FAM59B -0.73 -10.27 -0.49 1.06e-21 Gut microbiome composition (summer); LUSC cis rs72781680 1.000 rs72796388 chr2:24171509 A/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs36093844 0.898 rs11512932 chr11:85591130 T/G cg25872744 chr11:85566296 CCDC83 -0.42 -6.2 -0.32 1.64e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs9653442 0.545 rs2009094 chr2:100765077 G/A cg22139774 chr2:100720529 AFF3 -0.42 -7.25 -0.37 2.9e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2898290 0.622 rs1382567 chr8:11350899 T/C cg27411982 chr8:10470053 RP1L1 -0.43 -6.95 -0.36 1.92e-11 Systolic blood pressure; LUSC cis rs2760061 0.784 rs1745414 chr1:228212159 T/A cg18477163 chr1:228402036 OBSCN 0.63 12.25 0.56 9.69e-29 Diastolic blood pressure; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg22907277 chr7:1156413 C7orf50 0.51 7.53 0.38 4.75e-13 Longevity;Endometriosis; LUSC cis rs7772486 0.875 rs2777477 chr6:146305491 A/G cg23711669 chr6:146136114 FBXO30 0.85 15.19 0.64 5.67e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs2302777 0.507 rs9889716 chr17:38108298 A/G cg17467752 chr17:38218738 THRA 0.41 5.69 0.3 2.73e-8 Multiple myeloma (hyperdiploidy); LUSC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg06494592 chr3:125709126 NA -0.52 -5.93 -0.31 7.44e-9 Blood pressure (smoking interaction); LUSC cis rs11098499 0.754 rs1980025 chr4:120252806 A/G cg09307838 chr4:120376055 NA -0.68 -10.64 -0.5 5.85e-23 Corneal astigmatism; LUSC trans rs62238980 0.614 rs75805646 chr22:32441396 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC trans rs12310956 0.532 rs1589903 chr12:33943019 C/T cg26384229 chr12:38710491 ALG10B 0.75 11.9 0.55 1.87e-27 Morning vs. evening chronotype; LUSC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg11752832 chr7:134001865 SLC35B4 0.57 8.76 0.43 1.02e-16 Mean platelet volume; LUSC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg06138931 chr13:21896616 NA 0.46 8.29 0.41 2.72e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs11214589 0.651 rs11214595 chr11:113259658 G/T cg14159747 chr11:113255604 NA 0.29 7.72 0.39 1.37e-13 Neuroticism; LUSC cis rs6546550 0.935 rs1377995 chr2:70064155 C/G cg02498382 chr2:70120550 SNRNP27 -0.29 -7.17 -0.37 4.87e-12 Prevalent atrial fibrillation; LUSC cis rs467650 0.529 rs2549200 chr5:97996348 T/C cg03885343 chr5:98108198 RGMB 0.32 5.76 0.3 1.95e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs9309473 0.660 rs11686541 chr2:73704475 C/G cg20560298 chr2:73613845 ALMS1 -0.55 -6.51 -0.34 2.69e-10 Metabolite levels; LUSC trans rs4718428 1.000 rs12534637 chr7:66327654 G/C cg18876405 chr7:65276391 NA 0.48 7.55 0.38 4.22e-13 Corneal structure; LUSC cis rs9341808 0.754 rs3805907 chr6:80973665 A/G cg08355045 chr6:80787529 NA -0.55 -9.7 -0.47 9.42e-20 Sitting height ratio; LUSC trans rs3960554 0.529 rs7793844 chr7:75883147 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 7.36 0.37 1.46e-12 Eotaxin levels; LUSC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg23625390 chr15:77176239 SCAPER 0.51 7.89 0.4 4.23e-14 Blood metabolite levels; LUSC cis rs7677751 0.806 rs4864857 chr4:55089814 T/C cg17187183 chr4:55093834 PDGFRA 0.38 5.72 0.3 2.31e-8 Corneal astigmatism; LUSC cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg17892150 chr10:133769511 PPP2R2D 0.67 9.52 0.46 3.59e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs977987 0.806 rs11640674 chr16:75394944 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.85 -0.35 3.47e-11 Dupuytren's disease; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -8.48 -0.42 7.32e-16 Lymphocyte counts; LUSC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.76 -0.3 1.93e-8 Depression; LUSC cis rs1670533 1.000 rs1670533 chr4:1078187 G/A cg27284194 chr4:1044797 NA 0.58 8.7 0.43 1.57e-16 Recombination rate (females); LUSC cis rs4285028 0.747 rs9824235 chr3:121432177 G/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.77 -0.57 1.07e-30 Multiple sclerosis; LUSC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg07701084 chr6:150067640 NUP43 0.56 8.74 0.43 1.15e-16 Lung cancer; LUSC cis rs17270561 0.579 rs10456326 chr6:25919662 G/A cg16482183 chr6:26056742 HIST1H1C 1.0 12.85 0.58 5.41e-31 Iron status biomarkers; LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs10788264 0.621 rs9633733 chr10:124056546 A/G cg09507567 chr10:124027408 NA -0.45 -7.76 -0.39 1.02e-13 Total body bone mineral density; LUSC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg09034736 chr1:150693464 HORMAD1 0.43 5.92 0.31 7.89e-9 Melanoma; LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC cis rs17270561 0.609 rs9358884 chr6:25756592 A/G cg17691542 chr6:26056736 HIST1H1C 0.58 8.09 0.4 1.13e-14 Iron status biomarkers; LUSC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.7 -10.96 -0.51 4.24e-24 Menarche (age at onset); LUSC cis rs2147959 0.882 rs4653551 chr1:228627913 A/G cg18477163 chr1:228402036 OBSCN 0.44 6.21 0.32 1.61e-9 Adult asthma; LUSC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg19257562 chr1:2043853 PRKCZ 0.33 6.6 0.34 1.64e-10 Height; LUSC cis rs861020 0.563 rs12046618 chr1:210043135 C/T cg05527609 chr1:210001259 C1orf107 0.85 11.3 0.53 2.73e-25 Orofacial clefts; LUSC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs314370 0.951 rs12666989 chr7:100486754 G/C cg18683606 chr7:100471612 SRRT 0.45 6.0 0.31 5.05e-9 Resting heart rate; LUSC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.97 0.36 1.74e-11 Intelligence (multi-trait analysis); LUSC cis rs4713675 0.546 rs3818521 chr6:33657246 C/T cg14003231 chr6:33640908 ITPR3 0.32 6.1 0.32 2.98e-9 Plateletcrit; LUSC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg06618935 chr21:46677482 NA -0.39 -7.73 -0.39 1.29e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12291225 0.679 rs7934671 chr11:14305101 C/T cg05501817 chr11:14380813 RRAS2 -0.58 -9.0 -0.44 1.71e-17 Sense of smell; LUSC cis rs9309473 1.000 rs6736866 chr2:73661986 C/G cg20560298 chr2:73613845 ALMS1 -0.52 -7.47 -0.38 7.16e-13 Metabolite levels; LUSC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg05776053 chr2:74358815 NA 0.42 6.61 0.34 1.5e-10 Gestational age at birth (maternal effect); LUSC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg21724239 chr8:58056113 NA 0.74 7.94 0.4 3.19e-14 Developmental language disorder (linguistic errors); LUSC cis rs6489882 0.867 rs7316586 chr12:113365828 C/T cg20102336 chr12:113376681 OAS3 -0.4 -5.7 -0.3 2.59e-8 Chronic lymphocytic leukemia; LUSC cis rs7539409 0.915 rs6576945 chr1:84252882 A/G cg10977910 chr1:84465055 TTLL7 0.73 5.85 0.3 1.19e-8 Alzheimer's disease; LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg11062466 chr8:58055876 NA 0.73 8.62 0.43 2.79e-16 Developmental language disorder (linguistic errors); LUSC cis rs698813 0.604 rs12712916 chr2:44482099 A/C cg00619915 chr2:44497795 NA -0.52 -7.31 -0.37 1.95e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs2730245 0.527 rs2527202 chr7:158738849 T/C cg24397884 chr7:158709396 WDR60 -0.78 -8.36 -0.42 1.67e-15 Height; LUSC cis rs7424096 0.515 rs17497343 chr2:37173032 T/C cg14987922 chr2:37194071 STRN 0.56 8.17 0.41 6.63e-15 High light scatter reticulocyte percentage of red cells; LUSC cis rs7923452 0.938 rs34930615 chr10:30761051 G/A cg18806716 chr10:30721971 MAP3K8 0.57 6.89 0.35 2.78e-11 Itch intensity from mosquito bite; LUSC cis rs6499755 0.932 rs12928690 chr16:55343565 C/T cg02859129 chr16:55357253 IRX6 0.36 6.08 0.32 3.33e-9 Hypospadias; LUSC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.51 7.2 0.37 4.01e-12 Tuberculosis; LUSC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg00999904 chr2:3704751 ALLC -0.44 -6.76 -0.35 6.12e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg24562669 chr7:97807699 LMTK2 0.36 6.29 0.33 9.85e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg24692254 chr21:30365293 RNF160 -0.82 -15.21 -0.64 4.55e-40 Dental caries; LUSC cis rs11605924 0.901 rs7105751 chr11:45856973 G/A ch.11.939596F chr11:45881766 CRY2 -0.5 -7.4 -0.38 1.13e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg13453750 chr1:205783389 SLC41A1 -0.29 -5.85 -0.31 1.14e-8 Menarche (age at onset); LUSC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg15017067 chr4:17643749 FAM184B 0.35 5.76 0.3 1.86e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11122272 0.735 rs2790886 chr1:231529491 A/C cg06096015 chr1:231504339 EGLN1 0.58 10.42 0.5 3.38e-22 Hemoglobin concentration; LUSC cis rs13401104 0.796 rs11894483 chr2:237114619 T/C cg19324714 chr2:237145437 ASB18 0.42 5.71 0.3 2.46e-8 Educational attainment; LUSC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg01416388 chr22:39784598 NA -0.46 -7.8 -0.39 7.98e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg06873352 chr17:61820015 STRADA 0.73 13.13 0.58 4.77e-32 Prudent dietary pattern; LUSC cis rs11098499 0.954 rs12505469 chr4:120249585 C/T cg09307838 chr4:120376055 NA 0.81 12.05 0.55 5.27e-28 Corneal astigmatism; LUSC cis rs7568458 0.684 rs6731700 chr2:85760991 C/G cg17127132 chr2:85788382 GGCX 0.42 6.06 0.31 3.62e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg19812747 chr11:111475976 SIK2 -0.52 -7.6 -0.38 2.92e-13 Primary sclerosing cholangitis; LUSC trans rs61931739 0.533 rs7970871 chr12:33917301 G/A cg13010199 chr12:38710504 ALG10B 0.4 6.03 0.31 4.34e-9 Morning vs. evening chronotype; LUSC trans rs6869502 0.871 rs13354207 chr5:110151791 C/G cg08170757 chr19:48867271 TMEM143;SYNGR4 -0.45 -5.95 -0.31 6.69e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.33 0.62 1.18e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.01 13.44 0.59 3.37e-33 Platelet count; LUSC cis rs920590 0.796 rs7820520 chr8:19634864 A/G cg03894339 chr8:19674705 INTS10 -0.43 -5.85 -0.3 1.17e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs4555082 0.834 rs28489970 chr14:105748862 T/C cg27165867 chr14:105738592 BRF1 -0.51 -7.25 -0.37 2.86e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs10465746 0.967 rs1570690 chr1:84377515 G/T cg10977910 chr1:84465055 TTLL7 0.41 5.9 0.31 8.91e-9 Obesity-related traits; LUSC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg13390004 chr1:15929781 NA 0.41 6.9 0.35 2.66e-11 Systolic blood pressure; LUSC cis rs929354 0.742 rs11980541 chr7:156988776 G/C cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.73 -0.3 2.25e-8 Depression; LUSC cis rs6542838 0.673 rs1949424 chr2:99468341 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.47 6.3 0.33 9.25e-10 Fear of minor pain; LUSC cis rs12476592 0.602 rs262504 chr2:63861235 C/G cg10828910 chr2:63850056 LOC388955 0.49 5.78 0.3 1.71e-8 Childhood ear infection; LUSC cis rs11979158 0.503 rs10256393 chr7:55027846 A/C cg23757825 chr7:55092271 EGFR 0.62 8.14 0.41 7.99e-15 Glioma; LUSC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg06212747 chr3:49208901 KLHDC8B -0.56 -8.32 -0.41 2.35e-15 Menarche (age at onset); LUSC cis rs6500602 0.673 rs1861652 chr16:4505331 C/T cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.73 0.35 7.37e-11 Schizophrenia; LUSC trans rs853679 0.517 rs17711344 chr6:28077602 A/G cg06606381 chr12:133084897 FBRSL1 0.47 6.47 0.33 3.41e-10 Depression; LUSC cis rs4343996 0.840 rs1917689 chr7:3317586 G/A cg21248987 chr7:3385318 SDK1 0.4 6.96 0.36 1.79e-11 Motion sickness; LUSC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg00745463 chr17:30367425 LRRC37B -0.79 -8.77 -0.43 9.4e-17 Hip circumference adjusted for BMI; LUSC cis rs3126085 0.935 rs6666382 chr1:152217226 C/G cg26876637 chr1:152193138 HRNR -0.46 -6.31 -0.33 8.7e-10 Atopic dermatitis; LUSC trans rs890100 0.902 rs2194801 chr2:56733863 A/C cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.32 -6.23 -0.32 1.42e-9 Gut microbiome composition (summer); LUSC cis rs16867321 0.614 rs10204086 chr2:181449668 G/T cg23363182 chr2:181467187 NA -0.58 -9.39 -0.46 9.42e-19 Obesity; LUSC cis rs67539049 1.000 rs67526040 chr8:11302996 G/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.41 -6.31 -0.33 8.86e-10 Itch intensity from mosquito bite; LUSC cis rs752010 0.714 rs10890144 chr1:42085397 G/T cg06885757 chr1:42089581 HIVEP3 0.46 9.69 0.47 1.02e-19 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs4474465 0.850 rs10899528 chr11:78207686 T/C cg27205649 chr11:78285834 NARS2 0.51 6.0 0.31 5.16e-9 Alzheimer's disease (survival time); LUSC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg01017244 chr2:74357527 NA 0.74 14.39 0.62 7.35e-37 Gestational age at birth (maternal effect); LUSC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg11752832 chr7:134001865 SLC35B4 0.53 7.99 0.4 2.29e-14 Mean platelet volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20283668 chr1:87797390 LMO4 -0.44 -6.57 -0.34 1.91e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7580658 0.724 rs4662711 chr2:127990840 G/A cg09760422 chr2:128146352 NA -0.3 -6.73 -0.35 7.18e-11 Protein C levels; LUSC cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg24006582 chr15:45444508 DUOX1 -0.61 -8.83 -0.44 5.89e-17 Uric acid levels; LUSC cis rs1801251 0.896 rs7573208 chr2:233696701 C/A cg08000102 chr2:233561755 GIGYF2 -0.67 -11.06 -0.52 2.01e-24 Coronary artery disease; LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg09904177 chr6:26538194 HMGN4 -0.75 -6.61 -0.34 1.51e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg11764359 chr7:65958608 NA 0.7 10.76 0.51 2.14e-23 Aortic root size; LUSC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg02951883 chr7:2050386 MAD1L1 -0.62 -12.19 -0.55 1.57e-28 Bipolar disorder and schizophrenia; LUSC cis rs6740322 0.895 rs6544643 chr2:43560072 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.55 -0.38 4.07e-13 Coronary artery disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18393173 chr6:34856135 ANKS1A;TAF11 0.42 6.61 0.34 1.56e-10 Triglycerides; LUSC cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg14019146 chr3:50243930 SLC38A3 0.48 11.68 0.54 1.13e-26 Intelligence (multi-trait analysis); LUSC cis rs4290604 0.748 rs10929216 chr2:238080938 C/T cg23555395 chr2:238036564 NA -0.47 -6.41 -0.33 4.85e-10 Asthma; LUSC cis rs6977660 0.714 rs10270468 chr7:19810559 T/C cg07541023 chr7:19748670 TWISTNB 0.61 6.6 0.34 1.61e-10 Thyroid stimulating hormone; LUSC cis rs314370 1.000 rs12705089 chr7:100465355 C/T cg18683606 chr7:100471612 SRRT 0.44 5.78 0.3 1.74e-8 Resting heart rate; LUSC cis rs11229555 0.645 rs34794607 chr11:58188401 A/T cg15696309 chr11:58395628 NA -0.67 -8.13 -0.41 8.64e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1997103 1.000 rs9642578 chr7:55400320 A/G cg17469321 chr7:55412551 NA 0.67 10.79 0.51 1.72e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs8181588 1.000 rs11602964 chr11:2825871 C/T cg23136573 chr6:52230573 PAQR8 0.73 5.95 0.31 6.6e-9 Type 2 diabetes; LUSC trans rs57046232 0.552 rs6076987 chr20:6351417 A/C cg21095983 chr6:86352623 SYNCRIP 0.47 6.94 0.36 1.99e-11 Colorectal cancer; LUSC cis rs7786808 0.552 rs2878456 chr7:158182129 A/T cg09998033 chr7:158218633 PTPRN2 -0.51 -8.24 -0.41 4.1e-15 Obesity-related traits; LUSC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg11764359 chr7:65958608 NA -0.7 -11.04 -0.52 2.34e-24 Aortic root size; LUSC cis rs7831492 0.564 rs6981979 chr8:41612255 C/T cg17182837 chr8:41585554 ANK1 -0.27 -5.65 -0.3 3.5e-8 Colorectal cancer; LUSC cis rs12122100 0.742 rs12122092 chr1:146508874 C/G cg03526459 chr1:146549940 NA -0.41 -6.75 -0.35 6.44e-11 HIV-1 control; LUSC cis rs9399401 0.626 rs3817928 chr6:142750516 A/G cg03128060 chr6:142623767 GPR126 0.53 8.75 0.43 1.04e-16 Chronic obstructive pulmonary disease; LUSC cis rs6840360 0.593 rs3805356 chr4:152680701 C/T cg22705602 chr4:152727874 NA 0.35 7.85 0.39 5.7e-14 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg08118646 chr4:99850258 EIF4E 0.43 6.36 0.33 6.57e-10 Triglycerides; LUSC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg05025164 chr4:1340916 KIAA1530 0.54 8.5 0.42 6.4e-16 Obesity-related traits; LUSC cis rs7945705 0.905 rs7947631 chr11:8844909 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -8.45 -0.42 8.95e-16 Hemoglobin concentration; LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg13047869 chr3:10149882 C3orf24 0.54 7.03 0.36 1.18e-11 Alzheimer's disease; LUSC cis rs765787 0.530 rs4774550 chr15:45542312 C/T cg24006582 chr15:45444508 DUOX1 -0.62 -9.14 -0.45 6.14e-18 Uric acid levels; LUSC cis rs35079168 0.735 rs3118540 chr9:137307106 C/T cg14344989 chr9:137329237 RXRA -0.36 -5.92 -0.31 8.07e-9 Intelligence; LUSC cis rs7824557 0.603 rs2249804 chr8:11215617 C/G cg27411982 chr8:10470053 RP1L1 0.42 6.45 0.33 3.99e-10 Retinal vascular caliber; LUSC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.78 -0.39 9.11e-14 Crohn's disease; LUSC cis rs12824058 0.816 rs1874522 chr12:130816536 C/T cg26677194 chr12:130822605 PIWIL1 -0.58 -9.03 -0.44 1.43e-17 Menopause (age at onset); LUSC cis rs8113142 0.614 rs4805259 chr19:29171420 C/T cg04546413 chr19:29218101 NA 0.45 6.01 0.31 4.82e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs28374715 0.532 rs316607 chr15:41772693 G/A cg18705301 chr15:41695430 NDUFAF1 -1.03 -20.95 -0.75 8.07e-63 Ulcerative colitis; LUSC cis rs6582630 0.519 rs11495373 chr12:38275470 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.42 0.64 7.1e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg08888203 chr3:10149979 C3orf24 0.66 9.28 0.45 2.15e-18 Alzheimer's disease; LUSC cis rs4561483 0.549 rs33659 chr16:11963361 A/G cg08843971 chr16:11963173 GSPT1 -0.43 -6.68 -0.34 1.02e-10 Testicular germ cell tumor; LUSC cis rs7189233 0.531 rs9929873 chr16:53490676 C/T cg09728985 chr16:53543985 NA -0.32 -6.14 -0.32 2.38e-9 Intelligence (multi-trait analysis); LUSC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg09703963 chr11:616879 IRF7;MUPCDH -0.45 -7.15 -0.36 5.4e-12 Systemic lupus erythematosus; LUSC cis rs617219 0.889 rs1533760 chr5:78438937 A/C cg24856658 chr5:78533917 JMY -0.3 -5.66 -0.3 3.29e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs1215050 0.765 rs471500 chr4:98714820 T/C cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.32e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg22467129 chr15:76604101 ETFA -0.46 -7.33 -0.37 1.73e-12 Blood metabolite levels; LUSC cis rs9300255 0.739 rs12824957 chr12:123750228 T/C cg05973401 chr12:123451056 ABCB9 -0.54 -5.72 -0.3 2.4e-8 Neutrophil percentage of white cells; LUSC cis rs7674212 0.540 rs2720469 chr4:104086484 C/T cg16532752 chr4:104119610 CENPE -0.5 -7.34 -0.37 1.65e-12 Type 2 diabetes; LUSC trans rs1997103 0.863 rs2140916 chr7:55403154 A/C cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg03146154 chr1:46216737 IPP -0.51 -7.46 -0.38 7.41e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg08219700 chr8:58056026 NA 0.69 8.07 0.4 1.27e-14 Developmental language disorder (linguistic errors); LUSC cis rs2281558 0.837 rs67676850 chr20:25369417 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.63 9.64 0.47 1.44e-19 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg26769984 chr7:1090371 C7orf50 0.71 9.98 0.48 1.1e-20 Bronchopulmonary dysplasia; LUSC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.62 6.06 0.31 3.63e-9 Cerebrospinal P-tau181p levels; LUSC cis rs2370759 1.000 rs2769241 chr10:32556229 T/C cg01819863 chr10:32635814 EPC1 -1.05 -12.82 -0.57 6.9e-31 Sexual dysfunction (female); LUSC trans rs7824557 0.628 rs3174048 chr8:11184937 G/A cg06636001 chr8:8085503 FLJ10661 0.42 6.14 0.32 2.35e-9 Retinal vascular caliber; LUSC cis rs9487051 1.000 rs13191948 chr6:109634599 C/T cg12927641 chr6:109611667 NA -0.36 -6.11 -0.32 2.8e-9 Reticulocyte fraction of red cells; LUSC cis rs9326248 0.510 rs4938332 chr11:116930798 A/G cg11861562 chr11:117069780 TAGLN 0.33 6.38 0.33 5.8e-10 Blood protein levels; LUSC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg20398880 chr6:41068722 NFYA;LOC221442 0.4 6.34 0.33 7.58e-10 Alzheimer's disease (late onset); LUSC cis rs7580658 0.676 rs58475809 chr2:128002650 A/G cg09760422 chr2:128146352 NA -0.27 -5.9 -0.31 8.85e-9 Protein C levels; LUSC cis rs600626 0.529 rs11236527 chr11:75469310 A/G cg24262691 chr11:75473276 NA -0.48 -6.34 -0.33 7.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7903847 0.642 rs10882922 chr10:99158537 C/T cg20016023 chr10:99160130 RRP12 -0.32 -7.98 -0.4 2.38e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs853679 0.546 rs71537572 chr6:27970715 T/C cg26958806 chr6:27640298 NA 0.72 5.79 0.3 1.6e-8 Depression; LUSC cis rs7605378 0.964 rs2689763 chr2:200689555 G/A cg17644776 chr2:200775616 C2orf69 0.36 5.7 0.3 2.67e-8 Osteoporosis; LUSC cis rs9393777 0.920 rs34953377 chr6:27381660 T/C cg09904177 chr6:26538194 HMGN4 -0.75 -5.76 -0.3 1.95e-8 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg11344533 chr11:111475393 SIK2 -0.49 -6.68 -0.34 1.01e-10 Primary sclerosing cholangitis; LUSC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.99 -0.4 2.17e-14 Mean platelet volume; LUSC cis rs1153858 1.000 rs1145085 chr15:45657804 A/G cg26924012 chr15:45694286 SPATA5L1 1.13 20.62 0.75 1.62e-61 Homoarginine levels; LUSC cis rs1538970 0.962 rs4660301 chr1:45820149 T/A cg06784218 chr1:46089804 CCDC17 0.33 5.91 0.31 8.22e-9 Platelet count; LUSC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg10802521 chr3:52805072 NEK4 0.48 7.0 0.36 1.42e-11 Bipolar disorder; LUSC trans rs561341 1.000 rs7210970 chr17:30262169 G/A cg27661571 chr11:113659931 NA -0.56 -6.64 -0.34 1.25e-10 Hip circumference adjusted for BMI; LUSC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC trans rs12692738 0.526 rs355855 chr2:165628875 C/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 7.28 0.37 2.44e-12 Rheumatoid arthritis; LUSC trans rs12579753 0.871 rs10862364 chr12:82201280 C/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs9326248 0.539 rs10892065 chr11:116897024 T/C cg26566898 chr11:117069891 TAGLN 0.34 6.46 0.33 3.77e-10 Blood protein levels; LUSC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg00310523 chr12:86230176 RASSF9 0.5 9.41 0.46 8.3e-19 Major depressive disorder; LUSC cis rs9902453 1.000 rs9891871 chr17:28370191 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.89 -0.44 3.97e-17 Coffee consumption (cups per day); LUSC cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg24692254 chr21:30365293 RNF160 -0.7 -10.68 -0.5 4.38e-23 Pancreatic cancer; LUSC cis rs113835537 0.529 rs60358007 chr11:66222353 G/A cg24851651 chr11:66362959 CCS 0.55 7.96 0.4 2.8e-14 Airway imaging phenotypes; LUSC cis rs709400 0.567 rs28496120 chr14:103897899 C/T cg12935359 chr14:103987150 CKB -0.51 -7.71 -0.39 1.46e-13 Body mass index; LUSC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg20203395 chr5:56204925 C5orf35 -0.47 -6.72 -0.34 8.02e-11 Coronary artery disease; LUSC cis rs7246657 0.943 rs8111782 chr19:37867904 A/G cg23950597 chr19:37808831 NA -0.63 -7.51 -0.38 5.51e-13 Coronary artery calcification; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg25767906 chr1:53392781 SCP2 0.48 8.66 0.43 1.98e-16 Monocyte count; LUSC cis rs1878931 0.580 rs4578649 chr16:3407258 C/T cg00484396 chr16:3507460 NAT15 0.38 6.44 0.33 4.1e-10 Body mass index (adult); LUSC cis rs59104589 0.583 rs61689231 chr2:242244583 G/A cg14842376 chr2:242211374 HDLBP 0.56 6.25 0.32 1.22e-9 Fibrinogen levels; LUSC cis rs6696846 0.777 rs6664397 chr1:205051871 C/T cg00857998 chr1:205179979 DSTYK 0.57 8.86 0.44 4.96e-17 Red blood cell count; LUSC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.0 -0.36 1.44e-11 Alzheimer's disease (late onset); LUSC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg10169327 chr19:45448959 APOC2 0.31 6.57 0.34 1.95e-10 Blood protein levels; LUSC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.6 12.18 0.55 1.79e-28 Monocyte percentage of white cells; LUSC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg19774624 chr17:42201019 HDAC5 -0.81 -13.27 -0.59 1.43e-32 Total body bone mineral density; LUSC cis rs2404602 0.647 rs11072631 chr15:77132909 T/C cg23625390 chr15:77176239 SCAPER -0.66 -9.96 -0.48 1.29e-20 Blood metabolite levels; LUSC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.86e-11 Aortic root size; LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg10150615 chr22:24372951 LOC391322 -0.34 -5.77 -0.3 1.81e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg13531842 chr10:38383804 ZNF37A -0.45 -7.08 -0.36 8.53e-12 Extrinsic epigenetic age acceleration; LUSC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg19318889 chr4:1322082 MAEA 0.48 7.83 0.39 6.66e-14 Obesity-related traits; LUSC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.27e-8 Aortic root size; LUSC cis rs739496 0.744 rs10849951 chr12:111910912 G/A cg10833066 chr12:111807467 FAM109A 0.31 5.67 0.3 3.16e-8 Platelet count; LUSC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg18132916 chr6:79620363 NA -0.41 -6.24 -0.32 1.36e-9 Intelligence (multi-trait analysis); LUSC cis rs7746199 0.736 rs34105070 chr6:27560805 C/T cg26958806 chr6:27640298 NA 0.76 6.21 0.32 1.54e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg26061582 chr7:22766209 IL6 0.49 7.02 0.36 1.25e-11 Lung cancer; LUSC cis rs61931739 0.534 rs11052959 chr12:33997095 T/C cg06521331 chr12:34319734 NA -0.46 -7.33 -0.37 1.73e-12 Morning vs. evening chronotype; LUSC cis rs12220238 0.915 rs11001020 chr10:76139217 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.52 5.76 0.3 1.91e-8 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg15103426 chr22:29168792 CCDC117 -0.47 -6.22 -0.32 1.5e-9 Lymphocyte counts; LUSC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6489785 0.710 rs2393717 chr12:121220375 G/C cg02419362 chr12:121203948 SPPL3 0.41 7.35 0.37 1.57e-12 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9837602 1.000 rs1688766 chr3:99647850 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.93 -0.31 7.52e-9 Breast cancer; LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg18758796 chr5:131593413 PDLIM4 0.39 6.41 0.33 5.08e-10 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03855706 chr16:770778 FAM173A 0.47 6.91 0.35 2.49e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2486288 0.656 rs2271438 chr15:45557468 A/G cg09092052 chr15:45571596 NA 0.45 6.3 0.33 9.44e-10 Glomerular filtration rate; LUSC cis rs6456156 0.586 rs2345753 chr6:167484344 T/A cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.12 -0.36 6.8e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg12292205 chr6:26970375 C6orf41 0.66 11.49 0.53 5.81e-26 Autism spectrum disorder or schizophrenia; LUSC cis rs9303280 0.901 rs7216389 chr17:38069949 C/T cg19468946 chr17:37922297 IKZF3 0.39 6.21 0.32 1.56e-9 Self-reported allergy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13611226 chr9:125027073 RBM18;MRRF -0.43 -6.43 -0.33 4.34e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs656319 0.559 rs17689007 chr8:9974824 G/A cg15556689 chr8:8085844 FLJ10661 -0.44 -6.37 -0.33 6.15e-10 Myopia (pathological); LUSC cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.02 0.58 1.25e-31 Chronic sinus infection; LUSC cis rs3768617 0.510 rs10737245 chr1:183100884 G/A ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC trans rs2018683 0.707 rs2391718 chr7:28974988 T/C cg19402173 chr7:128379420 CALU -0.47 -7.17 -0.37 4.86e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg21573476 chr21:45109991 RRP1B 0.4 6.44 0.33 4.14e-10 Mean corpuscular volume; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04827747 chr7:134855666 C7orf49 -0.44 -6.28 -0.32 1.08e-9 Electrocardiographic conduction measures; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.6 10.03 0.48 7.04e-21 Lymphocyte counts; LUSC cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg07636037 chr3:49044803 WDR6 -0.66 -8.39 -0.42 1.36e-15 Menarche (age at onset); LUSC cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs921968 0.643 rs13431399 chr2:219469498 G/C cg02176678 chr2:219576539 TTLL4 -0.75 -14.34 -0.62 1.11e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.43 6.12 0.32 2.58e-9 Breast cancer; LUSC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.39 0.56 2.97e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3092073 0.624 rs3848714 chr20:44547176 T/C cg23303369 chr20:44641161 MMP9 0.35 6.12 0.32 2.59e-9 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg06850241 chr22:41845214 NA 0.31 5.8 0.3 1.56e-8 Vitiligo; LUSC cis rs7520050 0.807 rs3013595 chr1:46153203 G/A cg06784218 chr1:46089804 CCDC17 0.3 5.94 0.31 7.18e-9 Red blood cell count;Reticulocyte count; LUSC cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg09035930 chr12:129282057 SLC15A4 -0.69 -14.79 -0.63 2.02e-38 Systemic lupus erythematosus; LUSC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg24829409 chr8:58192753 C8orf71 -0.55 -6.01 -0.31 4.79e-9 Developmental language disorder (linguistic errors); LUSC cis rs12681288 0.676 rs2701901 chr8:1017816 G/C cg15309053 chr8:964076 NA 0.38 7.57 0.38 3.64e-13 Schizophrenia; LUSC cis rs1577917 1.000 rs117907570 chr6:86601283 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.29 -0.41 2.86e-15 Response to antipsychotic treatment; LUSC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg12386194 chr3:101231763 SENP7 0.54 7.53 0.38 4.91e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.48 -6.38 -0.33 5.88e-10 Eosinophil percentage of white cells; LUSC cis rs4974559 0.739 rs10032327 chr4:1323537 C/T cg02980000 chr4:1222292 CTBP1 1.04 9.6 0.46 2e-19 Systolic blood pressure; LUSC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.12 0.52 1.2e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs9479482 1.000 rs9479481 chr6:150357944 A/G cg03788504 chr6:150331562 NA -0.25 -5.74 -0.3 2.12e-8 Alopecia areata; LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg00149659 chr3:10157352 C3orf10 0.9 12.52 0.57 9.79e-30 Alzheimer's disease; LUSC cis rs1595825 0.891 rs7587716 chr2:198630667 G/T cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 5.92e-9 Ulcerative colitis; LUSC cis rs4704187 0.687 rs4704176 chr5:74420596 G/C cg03227963 chr5:74354835 NA 0.32 6.89 0.35 2.72e-11 Response to amphetamines; LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.17 0.32 1.96e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4730250 0.707 rs10253291 chr7:106786550 C/A cg02696742 chr7:106810147 HBP1 0.64 9.05 0.44 1.17e-17 Osteoarthritis; LUSC cis rs2153904 0.793 rs1772145 chr1:205695695 C/T cg11965913 chr1:205819406 PM20D1 0.46 5.96 0.31 6.44e-9 Prostate-specific antigen levels; LUSC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg16447950 chr5:562315 NA -0.57 -7.3 -0.37 2.1e-12 Lung disease severity in cystic fibrosis; LUSC trans rs11098499 0.865 rs1112817 chr4:120297800 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs259282 0.560 rs4805786 chr19:33120265 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.78 12.08 0.55 4.05e-28 Schizophrenia; LUSC cis rs926938 0.618 rs904292 chr1:115358421 C/T cg12756093 chr1:115239321 AMPD1 0.52 7.73 0.39 1.27e-13 Autism; LUSC cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg01657329 chr11:68192670 LRP5 -0.44 -6.48 -0.33 3.21e-10 Total body bone mineral density; LUSC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg15556689 chr8:8085844 FLJ10661 0.65 9.89 0.48 2.14e-20 Mean corpuscular volume; LUSC cis rs11711311 0.955 rs9830102 chr3:113408302 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.41 -5.78 -0.3 1.74e-8 IgG glycosylation; LUSC cis rs7845219 0.539 rs10441538 chr8:95868608 G/A cg13393036 chr8:95962371 TP53INP1 -0.38 -7.71 -0.39 1.41e-13 Type 2 diabetes; LUSC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg06627628 chr2:24431161 ITSN2 -0.61 -7.29 -0.37 2.19e-12 Lymphocyte counts; LUSC cis rs11048434 0.698 rs7300767 chr12:9123477 T/G cg13575925 chr12:9217583 LOC144571 0.35 6.39 0.33 5.64e-10 Sjögren's syndrome; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg17178900 chr1:205818956 PM20D1 0.51 8.18 0.41 6.13e-15 Menarche (age at onset); LUSC cis rs2282300 0.956 rs1717773 chr11:30383154 T/C cg25418670 chr11:30344373 C11orf46 -0.52 -7.25 -0.37 2.91e-12 Morning vs. evening chronotype; LUSC cis rs6582630 0.638 rs35864536 chr12:38472255 T/A cg13010199 chr12:38710504 ALG10B -0.43 -6.46 -0.33 3.79e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg18404041 chr3:52824283 ITIH1 -0.56 -9.51 -0.46 3.92e-19 Schizophrenia; LUSC cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs6840360 0.869 rs55668815 chr4:152473828 C/G cg22705602 chr4:152727874 NA -0.3 -6.2 -0.32 1.71e-9 Intelligence (multi-trait analysis); LUSC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg01448562 chr3:133502909 NA -0.52 -7.75 -0.39 1.13e-13 Iron status biomarkers; LUSC cis rs138918 0.772 rs138935 chr22:43567459 C/T cg08909806 chr22:43548696 TSPO 0.36 6.23 0.32 1.38e-9 Monocyte count; LUSC cis rs9814567 1.000 rs62269547 chr3:134214042 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.75 -0.6 2.1e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 16.31 0.67 2.06e-44 Platelet count; LUSC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg14196790 chr5:131705035 SLC22A5 0.45 7.28 0.37 2.4e-12 Breast cancer;Mosquito bite size; LUSC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg24675658 chr1:53192096 ZYG11B -0.77 -13.64 -0.6 5.71e-34 Monocyte count; LUSC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg08847533 chr14:75593920 NEK9 -0.84 -15.07 -0.64 1.61e-39 Height; LUSC cis rs11756438 0.572 rs2638552 chr6:118999412 C/T cg21191810 chr6:118973309 C6orf204 0.35 5.91 0.31 8.34e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs62238980 0.614 rs62240588 chr22:32358473 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -6.07 -0.32 3.42e-9 Childhood ear infection; LUSC cis rs3820928 0.874 rs1917122 chr2:227835681 C/T cg11843606 chr2:227700838 RHBDD1 -0.52 -7.42 -0.38 9.97e-13 Pulmonary function; LUSC cis rs34638657 0.518 rs4889467 chr16:82169385 C/T cg09439754 chr16:82129088 HSD17B2 -0.32 -5.83 -0.3 1.34e-8 Lung adenocarcinoma; LUSC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg09035930 chr12:129282057 SLC15A4 0.74 16.25 0.66 3.74e-44 Systemic lupus erythematosus; LUSC cis rs4595586 0.545 rs7307303 chr12:39368976 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs3790645 0.958 rs7543005 chr1:26879376 T/C cg17456097 chr1:26900765 RPS6KA1 0.41 6.01 0.31 4.81e-9 Glucose homeostasis traits; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06714284 chr1:235812840 GNG4 0.36 5.97 0.31 5.91e-9 Asthma; LUSC cis rs4906332 0.966 rs59858038 chr14:103867102 C/T cg04998671 chr14:104000505 TRMT61A -0.46 -7.13 -0.36 6.27e-12 Coronary artery disease; LUSC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06401114 chr19:19627257 NDUFA13;TSSK6 0.45 6.0 0.31 5.09e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg08736216 chr1:53307985 ZYG11A 0.31 6.33 0.33 8.05e-10 Monocyte count; LUSC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg16680214 chr1:154839983 KCNN3 -0.53 -9.88 -0.48 2.25e-20 Prostate cancer; LUSC cis rs813218 0.585 rs9860561 chr3:99917434 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.32 6.0 0.31 5.11e-9 Orofacial clefts; LUSC cis rs11971779 0.715 rs6943973 chr7:139029893 G/C cg07862535 chr7:139043722 LUC7L2 0.55 6.83 0.35 4.08e-11 Diisocyanate-induced asthma; LUSC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg00012203 chr2:219082015 ARPC2 -0.91 -17.34 -0.69 1.69e-48 Colorectal cancer; LUSC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg26769984 chr7:1090371 C7orf50 -0.56 -7.77 -0.39 9.54e-14 Bronchopulmonary dysplasia; LUSC cis rs67539049 1.000 rs2001462 chr8:11294810 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 0.41 6.42 0.33 4.6e-10 Itch intensity from mosquito bite; LUSC cis rs28647808 0.786 rs28458971 chr9:136255736 C/T cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs8060686 0.545 rs9931987 chr16:68256639 G/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.55 -0.34 2.13e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9547692 1.000 rs493248 chr13:37473386 C/T cg01493522 chr13:37497338 NA -0.4 -6.07 -0.32 3.47e-9 Coronary artery disease; LUSC cis rs9398803 0.965 rs2326387 chr6:126680489 G/A cg19875578 chr6:126661172 C6orf173 0.39 5.83 0.3 1.31e-8 Male-pattern baldness; LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg02018176 chr4:1364513 KIAA1530 0.57 10.4 0.49 3.85e-22 Longevity; LUSC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19557537 chr6:46620673 CYP39A1;SLC25A27 0.43 6.05 0.31 3.95e-9 Triglycerides; LUSC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg24733560 chr20:60626293 TAF4 0.36 5.89 0.31 9.44e-9 Body mass index; LUSC cis rs950169 0.845 rs4106951 chr15:84833394 C/G cg17507749 chr15:85114479 UBE2QP1 0.67 8.67 0.43 1.96e-16 Schizophrenia; LUSC cis rs7818345 1.000 rs12675717 chr8:19293177 G/A cg11303988 chr8:19266685 CSGALNACT1 0.37 7.15 0.36 5.67e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.11 -0.41 9.41e-15 Lung cancer; LUSC cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg04117972 chr1:227635322 NA 0.61 6.94 0.35 2.08e-11 Major depressive disorder; LUSC cis rs9467773 0.595 rs2451736 chr6:26620544 G/A cg05738196 chr6:26577821 NA 0.79 15.24 0.64 3.59e-40 Intelligence (multi-trait analysis); LUSC cis rs12928939 0.815 rs12446005 chr16:71655035 G/A cg08717414 chr16:71523259 ZNF19 -0.43 -6.01 -0.31 4.88e-9 Post bronchodilator FEV1; LUSC cis rs3126085 0.825 rs868303 chr1:152178563 C/A cg26876637 chr1:152193138 HRNR 0.45 6.28 0.33 1.05e-9 Atopic dermatitis; LUSC cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg03517284 chr6:25882590 NA -0.52 -9.66 -0.47 1.25e-19 Blood metabolite levels; LUSC cis rs9549367 0.601 rs558869 chr13:113849932 G/T cg00898013 chr13:113819073 PROZ 0.54 8.04 0.4 1.59e-14 Platelet distribution width; LUSC cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg20476274 chr7:133979776 SLC35B4 0.86 16.48 0.67 4.59e-45 Mean platelet volume; LUSC cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg27170947 chr2:26402098 FAM59B -0.64 -9.37 -0.46 1.11e-18 Gut microbiome composition (summer); LUSC trans rs7681440 0.904 rs6816469 chr4:90772885 G/C cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.97 -0.31 6.19e-9 Dementia with Lewy bodies; LUSC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg18477163 chr1:228402036 OBSCN 0.62 12.18 0.55 1.73e-28 Diastolic blood pressure; LUSC cis rs7568458 0.846 rs6705971 chr2:85761417 G/T cg23752985 chr2:85803571 VAMP8 -0.27 -5.71 -0.3 2.45e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg27535305 chr1:53392650 SCP2 -0.38 -7.1 -0.36 7.42e-12 Monocyte count; LUSC cis rs8099014 1.000 rs6566972 chr18:56123740 T/C cg12907477 chr18:56117327 MIR122 0.44 7.06 0.36 9.47e-12 Platelet count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15839673 chr15:90895473 ZNF774 0.74 5.99 0.31 5.48e-9 Cognitive performance; LUSC cis rs17433780 0.808 rs12122780 chr1:89508916 T/C cg09516651 chr1:89888402 LOC400759 0.61 11.67 0.54 1.25e-26 Carotid intima media thickness; LUSC cis rs10751667 0.666 rs7123912 chr11:963936 T/C ch.11.42038R chr11:967971 AP2A2 0.44 6.6 0.34 1.63e-10 Alzheimer's disease (late onset); LUSC cis rs9399135 0.967 rs9373122 chr6:135373534 G/A cg22676075 chr6:135203613 NA 0.46 7.15 0.36 5.34e-12 Red blood cell count; LUSC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs6456156 0.792 rs4710178 chr6:167513532 G/A cg07741184 chr6:167504864 NA 0.37 6.49 0.33 3.19e-10 Primary biliary cholangitis; LUSC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -7.99 -0.4 2.25e-14 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs62056376 0.646 rs2857653 chr17:32575759 T/C cg19986872 chr5:131347773 ACSL6 -0.41 -6.07 -0.32 3.57e-9 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg03929089 chr4:120376271 NA 0.86 12.25 0.56 9.39e-29 Height; LUSC cis rs9287719 0.967 rs6432120 chr2:10753771 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg18131467 chr2:239335373 ASB1 -1.04 -24.82 -0.81 7.94e-78 Multiple system atrophy; LUSC cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg25554036 chr4:6271136 WFS1 0.63 13.31 0.59 1.01e-32 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs35362007 0.530 rs17835086 chr14:96012465 A/G cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.59 5.7 0.3 2.6e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg04944784 chr2:26401820 FAM59B -0.66 -9.52 -0.46 3.73e-19 Gut microbiome composition (summer); LUSC cis rs4900538 0.927 rs1190544 chr14:102903398 G/A cg18135206 chr14:102964638 TECPR2 -1.05 -22.5 -0.78 7.18e-69 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs561341 1.000 rs484175 chr17:30309041 G/A cg20587970 chr11:113659929 NA -1.27 -17.75 -0.7 4.04e-50 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.09 -0.4 1.1e-14 Lung cancer; LUSC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg21435336 chr19:17392852 ANKLE1 -0.48 -6.51 -0.34 2.7e-10 Systemic lupus erythematosus; LUSC cis rs8046696 1 rs8046696 chr16:75442143 T/G cg03315344 chr16:75512273 CHST6 0.49 8.99 0.44 1.91e-17 Coronary artery disease; LUSC cis rs10089 1.000 rs10061367 chr5:127449021 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.77 0.54 5.38e-27 Ileal carcinoids; LUSC cis rs11098499 0.909 rs6842762 chr4:120398236 A/T cg24375607 chr4:120327624 NA 0.81 12.16 0.55 2.07e-28 Corneal astigmatism; LUSC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs6752107 1.000 rs6738490 chr2:234161583 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.71 11.91 0.55 1.74e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12545109 0.800 rs1530218 chr8:57407864 C/G cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.1e-10 Obesity-related traits; LUSC cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.34 7.02 0.36 1.22e-11 Hemoglobin concentration; LUSC cis rs2299587 0.585 rs2299590 chr8:17802192 A/C cg01800426 chr8:17659068 MTUS1 -0.49 -6.31 -0.33 8.64e-10 Economic and political preferences; LUSC cis rs1957429 0.901 rs1957427 chr14:65354085 A/G cg23373153 chr14:65346875 NA 0.96 11.48 0.53 6.33e-26 Pediatric areal bone mineral density (radius); LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg16325326 chr1:53192061 ZYG11B -0.82 -14.32 -0.62 1.33e-36 Monocyte count; LUSC trans rs12478296 0.534 rs67092377 chr2:243002171 T/G cg01596870 chr19:55963115 NA -0.55 -7.32 -0.37 1.91e-12 Obesity-related traits; LUSC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg25282410 chr6:160211355 TCP1;MRPL18 1.12 16.74 0.68 4.17e-46 Age-related macular degeneration (geographic atrophy); LUSC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg11812906 chr14:75593930 NEK9 -0.65 -11.03 -0.52 2.54e-24 Height; LUSC cis rs10887741 0.690 rs10509410 chr10:89440001 C/T cg24243914 chr10:89418206 PAPSS2 0.34 6.87 0.35 3.24e-11 Exercise (leisure time); LUSC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg00999904 chr2:3704751 ALLC -0.62 -9.89 -0.48 2.13e-20 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12291225 0.535 rs10832248 chr11:14413087 G/A cg19336497 chr11:14380999 RRAS2 -0.53 -11.25 -0.52 4.07e-25 Sense of smell; LUSC cis rs3947 1.000 rs1736082 chr8:11703420 C/T cg00262122 chr8:11665843 FDFT1 -0.48 -5.7 -0.3 2.7e-8 Blood protein levels; LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg22638593 chr5:131593259 PDLIM4 0.39 5.76 0.3 1.9e-8 Breast cancer; LUSC cis rs748404 0.631 rs7163288 chr15:43671355 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.7 0.34 8.92e-11 Lung cancer; LUSC trans rs656319 0.625 rs4526366 chr8:9890179 C/G cg21775007 chr8:11205619 TDH -0.47 -6.67 -0.34 1.07e-10 Myopia (pathological); LUSC cis rs1506636 0.646 rs805779 chr7:123214835 C/T cg03229431 chr7:123269106 ASB15 -0.6 -9.11 -0.45 8.02e-18 Plateletcrit;Platelet count; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg26330133 chr20:35089838 DLGAP4 -0.5 -6.11 -0.32 2.84e-9 Cognitive function;Information processing speed; LUSC cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 7.05 0.36 1.02e-11 Personality dimensions; LUSC trans rs60843830 0.928 rs55742348 chr2:217563 T/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.47 0.5 2.28e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9467773 0.583 rs1021373 chr6:26632457 G/A cg05738196 chr6:26577821 NA 0.78 14.95 0.63 4.82e-39 Intelligence (multi-trait analysis); LUSC cis rs4343996 0.934 rs4607498 chr7:3368197 C/T cg21248987 chr7:3385318 SDK1 -0.38 -6.42 -0.33 4.67e-10 Motion sickness; LUSC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg19539972 chr4:7069911 GRPEL1 0.72 9.06 0.44 1.13e-17 Monocyte percentage of white cells; LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg22920501 chr2:26401640 FAM59B -0.82 -12.46 -0.56 1.59e-29 Gut microbiome composition (summer); LUSC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.29e-12 Extrinsic epigenetic age acceleration; LUSC trans rs11743006 0.626 rs6859738 chr5:136500148 A/C cg07379741 chr17:7311030 NLGN2 0.41 6.18 0.32 1.89e-9 Mathematical ability; LUSC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg25072359 chr17:41440525 NA 0.66 9.25 0.45 2.8e-18 Menopause (age at onset); LUSC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg23758822 chr17:41437982 NA 1.05 19.04 0.72 3.07e-55 Menopause (age at onset); LUSC cis rs7586879 0.929 rs6545807 chr2:25124358 C/T cg15423357 chr2:25149977 NA 0.35 6.42 0.33 4.64e-10 Body mass index; LUSC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg24585782 chr17:78113791 EIF4A3 -0.53 -7.79 -0.39 8.61e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC trans rs7939886 0.920 rs61887958 chr11:55938234 A/G cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC cis rs7572644 0.665 rs4666017 chr2:28040525 C/A cg27432699 chr2:27873401 GPN1 0.57 7.28 0.37 2.47e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg25036284 chr2:26402008 FAM59B -0.69 -9.63 -0.47 1.6e-19 Gut microbiome composition (summer); LUSC cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg08798685 chr6:27730294 NA -0.64 -6.01 -0.31 4.93e-9 Breast cancer; LUSC cis rs2180341 0.618 rs4502958 chr6:127593113 G/A cg24812749 chr6:127587940 RNF146 0.65 9.73 0.47 7.3e-20 Breast cancer; LUSC cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg08807101 chr21:30365312 RNF160 -0.7 -12.16 -0.55 2.05e-28 Dental caries; LUSC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11644478 chr21:40555479 PSMG1 0.97 19.32 0.73 2.27e-56 Cognitive function; LUSC trans rs2055729 0.645 rs6989793 chr8:9744650 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -6.3 -0.33 9.23e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs6977940 0.818 rs73033457 chr7:2899235 C/A cg19731401 chr7:2775893 GNA12 0.63 7.37 0.37 1.33e-12 White matter integrity; LUSC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg04111992 chr7:158790115 NA -0.38 -5.89 -0.31 9.65e-9 Facial morphology (factor 20); LUSC cis rs5758511 0.689 rs55906806 chr22:42644471 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.62 -7.26 -0.37 2.66e-12 Birth weight; LUSC cis rs6982240 0.514 rs10095322 chr8:142262327 A/G cg27411547 chr8:142287226 NA -0.47 -8.02 -0.4 1.76e-14 Tonsillectomy; LUSC cis rs9420 0.961 rs80304923 chr11:57522823 C/G cg23127183 chr11:57508653 C11orf31 -0.57 -8.81 -0.43 6.86e-17 Schizophrenia; LUSC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg23711669 chr6:146136114 FBXO30 0.89 16.83 0.68 1.88e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg12560992 chr17:57184187 TRIM37 -0.87 -16.64 -0.67 1.09e-45 Intelligence (multi-trait analysis); LUSC cis rs116988415 0.584 rs75851540 chr14:65262909 C/T cg00114569 chr14:65239327 SPTB 0.7 7.43 0.38 9.24e-13 Daytime sleep phenotypes; LUSC cis rs9325144 0.647 rs11168741 chr12:38989120 C/T cg26384229 chr12:38710491 ALG10B -0.65 -10.1 -0.48 4.07e-21 Morning vs. evening chronotype; LUSC cis rs9549260 0.755 rs55920113 chr13:41222112 C/T cg21288729 chr13:41239152 FOXO1 0.65 10.07 0.48 5.25e-21 Red blood cell count; LUSC cis rs9457247 0.663 rs7749278 chr6:167435325 C/T cg23791538 chr6:167370224 RNASET2 0.39 6.28 0.33 1.05e-9 Crohn's disease; LUSC cis rs240764 0.817 rs6922219 chr6:101153907 G/C cg09795085 chr6:101329169 ASCC3 -0.43 -6.26 -0.32 1.2e-9 Neuroticism; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg16606324 chr3:10149918 C3orf24 0.66 9.8 0.47 4.38e-20 Alzheimer's disease; LUSC cis rs2294693 0.891 rs9367093 chr6:41012117 A/C cg14769373 chr6:40998127 UNC5CL -0.52 -6.93 -0.35 2.18e-11 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs66887589 0.807 rs13134517 chr4:120405262 G/A cg24375607 chr4:120327624 NA 0.5 7.77 0.39 9.66e-14 Diastolic blood pressure; LUSC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg15691649 chr6:25882328 NA 0.51 7.58 0.38 3.4e-13 Blood metabolite levels; LUSC cis rs4948102 0.597 rs12669623 chr7:56139179 G/C cg17215666 chr7:56131930 SUMF2 0.44 5.87 0.31 1.06e-8 Plasma homocysteine levels (post-methionine load test); LUSC cis rs7503807 0.935 rs62068348 chr17:78608575 T/C cg09596252 chr17:78655493 RPTOR 0.46 7.82 0.39 7.03e-14 Obesity; LUSC cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 7.25 0.37 2.85e-12 Colorectal cancer; LUSC cis rs9300255 0.569 rs1727320 chr12:123700476 T/A cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs7582720 1.000 rs72934735 chr2:203740010 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs66716358 0.773 rs2054029 chr11:44325700 T/G cg16977035 chr11:44330474 ALX4 0.36 5.87 0.31 1.06e-8 Monobrow; LUSC cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg16339924 chr4:17578868 LAP3 -0.54 -7.9 -0.4 4.04e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1568889 0.838 rs6484347 chr11:28040969 G/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.73 -13.31 -0.59 1.04e-32 Bipolar disorder; LUSC trans rs10435719 0.764 rs10103485 chr8:11787563 C/T cg14343924 chr8:8086146 FLJ10661 0.44 6.13 0.32 2.51e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg06238570 chr21:40685208 BRWD1 -0.57 -8.79 -0.43 8.32e-17 Menarche (age at onset); LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg03188948 chr7:1209495 NA 0.65 6.91 0.35 2.51e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg15501526 chr10:2543763 NA 0.68 11.59 0.54 2.37e-26 Age-related hearing impairment; LUSC trans rs9393777 0.777 rs56114371 chr6:27274834 C/T cg06606381 chr12:133084897 FBRSL1 -0.94 -8.31 -0.41 2.44e-15 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg20887711 chr4:1340912 KIAA1530 0.49 7.93 0.4 3.3e-14 Longevity; LUSC cis rs3858526 0.792 rs12363478 chr11:5987775 C/T cg02574844 chr11:5959923 NA -0.44 -6.17 -0.32 2.03e-9 DNA methylation (variation); LUSC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.19 0.64 5.68e-40 Intelligence (multi-trait analysis); LUSC cis rs7542375 0.507 rs2484697 chr1:221094718 A/G cg16008148 chr1:221062819 NA 0.43 8.29 0.41 2.89e-15 Obesity-related traits; LUSC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs7927771 0.524 rs10838771 chr11:47831332 A/G cg20307385 chr11:47447363 PSMC3 -0.44 -6.53 -0.34 2.4e-10 Subjective well-being; LUSC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg13319975 chr6:146136371 FBXO30 -0.71 -11.31 -0.53 2.5e-25 Lobe attachment (rater-scored or self-reported); LUSC trans rs2832077 0.943 rs2272701 chr21:30190907 C/T cg14791747 chr16:20752902 THUMPD1 0.73 9.55 0.46 2.84e-19 Cognitive test performance; LUSC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg11266682 chr4:10021025 SLC2A9 0.52 9.33 0.45 1.49e-18 Bone mineral density; LUSC cis rs1595825 1.000 rs73058834 chr2:198873779 T/G cg00982548 chr2:198649783 BOLL -0.51 -6.31 -0.33 8.95e-10 Ulcerative colitis; LUSC trans rs2018683 0.523 rs1499227 chr7:29025615 C/T cg19402173 chr7:128379420 CALU -0.43 -6.42 -0.33 4.72e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs10791097 0.967 rs6590512 chr11:130717916 A/G cg12179176 chr11:130786555 SNX19 -0.64 -9.89 -0.48 2.06e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.06 -0.72 2.5e-55 Height; LUSC cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg08999081 chr20:33150536 PIGU 0.52 10.26 0.49 1.2e-21 Glomerular filtration rate (creatinine); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02716147 chr3:126733173 PLXNA1 0.44 6.2 0.32 1.62e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10193935 0.901 rs10202848 chr2:42515661 A/G cg27598129 chr2:42591480 NA -0.59 -8.05 -0.4 1.44e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9581857 0.556 rs9579085 chr13:28041039 G/A cg22138327 chr13:27999177 GTF3A 0.71 9.57 0.46 2.41e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg08773314 chr2:239334832 ASB1 0.41 8.66 0.43 2.08e-16 Multiple system atrophy; LUSC cis rs11690935 1.000 rs11678984 chr2:172535848 T/G cg13550731 chr2:172543902 DYNC1I2 0.88 14.74 0.63 3.15e-38 Schizophrenia; LUSC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg26408565 chr15:76604113 ETFA -0.45 -7.02 -0.36 1.22e-11 Blood metabolite levels; LUSC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs6942756 1.000 rs17168512 chr7:128955033 A/G cg02491457 chr7:128862824 NA -0.47 -6.31 -0.33 9.1e-10 White matter hyperintensity burden; LUSC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs113835537 0.529 rs61561111 chr11:66275923 T/C cg24851651 chr11:66362959 CCS 0.53 7.95 0.4 2.91e-14 Airway imaging phenotypes; LUSC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg09997546 chr11:8931473 C11orf17;ST5 0.37 7.8 0.39 8.25e-14 Hemoglobin concentration; LUSC cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg26061582 chr7:22766209 IL6 -0.43 -5.96 -0.31 6.45e-9 Lung cancer; LUSC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg12292205 chr6:26970375 C6orf41 0.67 11.35 0.53 1.77e-25 Autism spectrum disorder or schizophrenia; LUSC trans rs4650994 0.544 rs6664493 chr1:178494428 C/T cg05059571 chr16:84539110 KIAA1609 -0.47 -8.88 -0.44 4.18e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg16405210 chr4:1374714 KIAA1530 0.55 8.2 0.41 5.09e-15 Obesity-related traits; LUSC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg05585544 chr11:47624801 NA -0.42 -7.18 -0.37 4.54e-12 Subjective well-being; LUSC trans rs2562456 0.833 rs4334427 chr19:21520892 A/G cg00806126 chr19:22604979 ZNF98 -0.43 -6.21 -0.32 1.6e-9 Pain; LUSC cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg20701182 chr2:24300061 SF3B14 0.88 11.42 0.53 1.05e-25 Lymphocyte counts; LUSC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg17971929 chr21:40555470 PSMG1 0.77 13.36 0.59 6.68e-33 Cognitive function; LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg03806693 chr22:41940476 POLR3H -0.9 -12.91 -0.58 3.35e-31 Vitiligo; LUSC cis rs807669 0.505 rs2236759 chr22:19187427 C/G cg02655711 chr22:19163373 SLC25A1 0.5 8.96 0.44 2.33e-17 Metabolite levels; LUSC cis rs9467773 1.000 rs11756120 chr6:26529808 G/C cg05738196 chr6:26577821 NA 0.82 15.81 0.65 1.93e-42 Intelligence (multi-trait analysis); LUSC cis rs7124681 0.528 rs74608150 chr11:47696214 A/T cg18512352 chr11:47633146 NA 0.28 5.84 0.3 1.26e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC trans rs62238980 0.522 rs117390331 chr22:32461489 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs6076065 0.963 rs999072 chr20:23347553 C/T cg11657817 chr20:23433608 CST11 0.44 8.73 0.43 1.23e-16 Facial morphology (factor 15, philtrum width); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13588640 chr5:77071865 TBCA -0.41 -6.14 -0.32 2.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17253792 0.822 rs10142757 chr14:56074211 C/A cg01858014 chr14:56050164 KTN1 -0.88 -7.16 -0.36 5.08e-12 Putamen volume; LUSC cis rs5769707 0.667 rs4824069 chr22:50030325 T/C cg05373962 chr22:49881684 NA -0.4 -8.66 -0.43 2.03e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg22325292 chr17:80708367 FN3K -0.41 -6.82 -0.35 4.29e-11 Glycated hemoglobin levels; LUSC trans rs8026898 1.000 rs919053 chr15:69990787 A/G cg27385734 chr18:15003734 NA 0.31 6.26 0.32 1.17e-9 Rheumatoid arthritis; LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.44 0.53 8.33e-26 Menopause (age at onset); LUSC cis rs870825 0.616 rs2696037 chr4:185610940 C/T cg04058563 chr4:185651563 MLF1IP -0.81 -11.99 -0.55 8.32e-28 Blood protein levels; LUSC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs62400317 0.859 rs11967630 chr6:45128524 G/C cg18551225 chr6:44695536 NA -0.42 -6.84 -0.35 3.81e-11 Total body bone mineral density; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg14893161 chr1:205819251 PM20D1 0.92 18.18 0.71 8.05e-52 Menarche (age at onset); LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg24060327 chr5:131705240 SLC22A5 -0.35 -5.91 -0.31 8.49e-9 Blood metabolite levels; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg07157834 chr1:205819609 PM20D1 0.89 16.47 0.67 5.01e-45 Menarche (age at onset); LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg15117754 chr3:10150083 C3orf24 -0.41 -5.66 -0.3 3.27e-8 Alzheimer's disease; LUSC cis rs6752107 0.936 rs1045100 chr2:234203597 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.59 0.54 2.52e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs734999 0.545 rs4648356 chr1:2709164 C/A cg18854424 chr1:2615690 NA 0.48 9.33 0.45 1.53e-18 Ulcerative colitis; LUSC cis rs910316 0.763 rs175047 chr14:75479039 C/G cg11812906 chr14:75593930 NEK9 -0.64 -10.43 -0.5 3.05e-22 Height; LUSC cis rs11997175 0.546 rs11775414 chr8:33615826 A/G ch.8.33884649F chr8:33765107 NA 0.51 8.12 0.41 9.29e-15 Body mass index; LUSC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg19077165 chr18:44547161 KATNAL2 -0.41 -6.14 -0.32 2.29e-9 Personality dimensions; LUSC cis rs9902453 0.967 rs61240589 chr17:28449035 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 8.08 0.4 1.17e-14 Coffee consumption (cups per day); LUSC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg11062466 chr8:58055876 NA 0.58 7.61 0.38 2.8e-13 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02895995 chr19:7554069 PEX11G 0.4 5.99 0.31 5.46e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.69 -11.28 -0.53 3.13e-25 Menarche (age at onset); LUSC cis rs4073582 0.595 rs555360 chr11:65960061 T/C cg16950941 chr11:66035639 RAB1B -0.48 -7.05 -0.36 1.06e-11 Gout; LUSC cis rs8013055 0.846 rs12717698 chr14:105979015 G/A cg19700328 chr14:106028568 NA -0.42 -6.93 -0.35 2.21e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC trans rs11075138 0.693 rs1713488 chr16:12739070 G/A cg07140468 chr10:44788627 NA 0.35 6.09 0.32 3.07e-9 Cerebral amyloid angiopathy; LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg01802117 chr1:53393560 SCP2 0.39 6.29 0.33 9.89e-10 Monocyte count; LUSC cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg12011299 chr4:100065546 ADH4 -0.73 -11.31 -0.53 2.45e-25 Alcohol dependence; LUSC cis rs1153858 1.000 rs1049508 chr15:45653592 A/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.28 0.49 1.04e-21 Homoarginine levels; LUSC cis rs7805747 1.000 rs56012466 chr7:151406788 G/A cg17611936 chr7:151411526 PRKAG2 0.44 5.84 0.3 1.22e-8 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); LUSC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.41 -6.41 -0.33 5.01e-10 Menarche (age at onset); LUSC cis rs12620999 0.941 rs2078469 chr2:237983273 C/G cg23555395 chr2:238036564 NA 0.52 9.2 0.45 3.97e-18 Systemic lupus erythematosus; LUSC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg02782426 chr3:40428986 ENTPD3 0.32 6.13 0.32 2.44e-9 Renal cell carcinoma; LUSC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg17385448 chr1:15911702 AGMAT 0.34 5.84 0.3 1.27e-8 Systolic blood pressure; LUSC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg07701084 chr6:150067640 NUP43 0.53 7.94 0.4 3.18e-14 Lung cancer; LUSC cis rs6500395 0.962 rs9934626 chr16:48602761 G/C cg04672837 chr16:48644449 N4BP1 0.45 6.53 0.34 2.48e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11971779 0.680 rs6960876 chr7:139112176 C/T cg07862535 chr7:139043722 LUC7L2 -0.57 -7.12 -0.36 6.84e-12 Diisocyanate-induced asthma; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01261044 chr14:35451962 SRP54 0.42 6.05 0.31 3.98e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg20503657 chr10:835505 NA 0.76 9.07 0.44 1.02e-17 Eosinophil percentage of granulocytes; LUSC trans rs8085804 0.571 rs76491133 chr18:40305701 C/A cg04486886 chr5:56784195 NA -0.31 -5.95 -0.31 6.95e-9 Cognitive performance; LUSC cis rs9309473 0.500 rs12996463 chr2:73655496 T/C cg20560298 chr2:73613845 ALMS1 0.45 7.14 0.36 5.98e-12 Metabolite levels; LUSC cis rs7089973 0.604 rs10490909 chr10:116593532 C/T cg23260525 chr10:116636907 FAM160B1 0.43 9.39 0.46 9.62e-19 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg18876405 chr7:65276391 NA 0.55 8.68 0.43 1.75e-16 Aortic root size; LUSC cis rs6840360 0.615 rs4696095 chr4:152467243 A/G cg22705602 chr4:152727874 NA -0.32 -6.47 -0.33 3.41e-10 Intelligence (multi-trait analysis); LUSC cis rs4730250 0.707 rs257386 chr7:106807783 C/G cg02696742 chr7:106810147 HBP1 -0.66 -9.21 -0.45 3.62e-18 Osteoarthritis; LUSC cis rs354225 0.584 rs11898032 chr2:54821515 G/A cg26097391 chr2:54893211 SPTBN1 0.41 6.27 0.32 1.12e-9 Schizophrenia; LUSC cis rs59104589 0.583 rs73002176 chr2:242332438 T/C cg14842376 chr2:242211374 HDLBP 0.57 6.62 0.34 1.48e-10 Fibrinogen levels; LUSC trans rs2048656 0.600 rs1976671 chr8:9679634 A/G cg06636001 chr8:8085503 FLJ10661 0.49 6.91 0.35 2.45e-11 Schizophrenia; LUSC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg12311346 chr5:56204834 C5orf35 0.84 13.95 0.61 3.75e-35 Initial pursuit acceleration; LUSC cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.53 -0.34 2.52e-10 Colorectal cancer; LUSC cis rs7937682 0.924 rs495460 chr11:111504777 G/A cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC trans rs2243480 1.000 rs316334 chr7:65602126 G/T cg10756647 chr7:56101905 PSPH 0.89 8.94 0.44 2.61e-17 Diabetic kidney disease; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg06873352 chr17:61820015 STRADA 0.7 12.62 0.57 3.94e-30 Prudent dietary pattern; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.05 -0.31 3.93e-9 Platelet count; LUSC cis rs9309711 0.621 rs12993215 chr2:3473727 T/C cg15506890 chr2:3487001 NA -0.53 -8.47 -0.42 7.81e-16 Neurofibrillary tangles; LUSC cis rs36051895 0.530 rs4142064 chr9:5221818 C/T cg02405213 chr9:5042618 JAK2 -0.51 -7.43 -0.38 9.11e-13 Pediatric autoimmune diseases; LUSC cis rs61931739 1.000 rs12304768 chr12:34000986 T/G cg06521331 chr12:34319734 NA 0.4 6.51 0.34 2.83e-10 Morning vs. evening chronotype; LUSC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg13683864 chr3:40499215 RPL14 -1.11 -21.66 -0.76 1.32e-65 Renal cell carcinoma; LUSC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg18230493 chr5:56204884 C5orf35 -0.85 -12.86 -0.58 5.13e-31 Initial pursuit acceleration; LUSC cis rs72634258 0.945 rs35675666 chr1:8021973 G/T cg26816564 chr1:7831052 VAMP3 0.47 5.68 0.3 2.96e-8 Inflammatory bowel disease; LUSC cis rs782590 0.805 rs782578 chr2:55915904 A/C cg18811423 chr2:55921094 PNPT1 0.9 16.03 0.66 2.76e-43 Metabolic syndrome; LUSC cis rs2637266 0.703 rs2583061 chr10:78558475 G/A cg18941641 chr10:78392320 NA 0.37 6.56 0.34 2.11e-10 Pulmonary function; LUSC cis rs7577696 0.924 rs7566162 chr2:32324072 T/C cg02381751 chr2:32503542 YIPF4 -0.4 -5.76 -0.3 1.87e-8 Inflammatory biomarkers; LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.53e-9 Menopause (age at onset); LUSC cis rs9747201 0.925 rs11867806 chr17:80072049 A/G cg17462356 chr17:80056334 FASN 0.47 6.14 0.32 2.35e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg12927641 chr6:109611667 NA -0.44 -7.65 -0.39 2.22e-13 Reticulocyte fraction of red cells; LUSC cis rs9611565 0.644 rs2413652 chr22:42097238 C/T cg03806693 chr22:41940476 POLR3H 0.86 12.66 0.57 2.85e-30 Vitiligo; LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.05 -0.31 3.99e-9 Developmental language disorder (linguistic errors); LUSC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg18479299 chr3:125709523 NA -0.5 -5.67 -0.3 3.03e-8 Blood pressure (smoking interaction); LUSC cis rs2637266 0.783 rs7900420 chr10:78476543 T/C cg18941641 chr10:78392320 NA 0.34 6.22 0.32 1.52e-9 Pulmonary function; LUSC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg10621924 chr7:39171070 POU6F2 0.51 7.91 0.4 3.76e-14 IgG glycosylation; LUSC cis rs7927771 0.524 rs10838739 chr11:47672743 A/G cg18512352 chr11:47633146 NA -0.28 -5.77 -0.3 1.8e-8 Subjective well-being; LUSC cis rs34421088 0.506 rs2572428 chr8:11146672 T/A cg21775007 chr8:11205619 TDH 0.48 7.14 0.36 5.83e-12 Neuroticism; LUSC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg22903471 chr2:27725779 GCKR -0.4 -6.84 -0.35 3.71e-11 Total body bone mineral density; LUSC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg22800045 chr5:56110881 MAP3K1 0.48 6.18 0.32 1.85e-9 Coronary artery disease; LUSC cis rs11122272 0.735 rs2572251 chr1:231514243 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg07701084 chr6:150067640 NUP43 0.57 8.83 0.44 5.96e-17 Lung cancer; LUSC cis rs2486288 0.656 rs12440356 chr15:45567529 T/C cg04036182 chr15:45458818 NA 0.36 5.78 0.3 1.69e-8 Glomerular filtration rate; LUSC cis rs7903847 0.642 rs10882910 chr10:99138043 G/A cg08345082 chr10:99160200 RRP12 -0.37 -7.56 -0.38 3.89e-13 Granulocyte percentage of myeloid white cells; LUSC trans rs3857536 0.776 rs9342535 chr6:66932963 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs6426558 0.537 rs12039370 chr1:227326472 A/G cg10327440 chr1:227177885 CDC42BPA -0.55 -7.41 -0.38 1.02e-12 Neutrophil percentage of white cells; LUSC cis rs13385 0.769 rs4913071 chr5:139560498 T/G cg26211634 chr5:139558579 C5orf32 0.45 6.54 0.34 2.25e-10 Atrial fibrillation; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03004578 chr6:64346172 NA -0.41 -6.37 -0.33 6.13e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg04511125 chr2:88470314 THNSL2 -0.44 -6.6 -0.34 1.62e-10 Response to metformin (IC50); LUSC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg22467129 chr15:76604101 ETFA 0.54 8.65 0.43 2.14e-16 Blood metabolite levels; LUSC trans rs4332037 0.539 rs11762545 chr7:2060775 C/T cg10840412 chr1:235813424 GNG4 0.57 7.34 0.37 1.61e-12 Bipolar disorder; LUSC trans rs1941687 0.831 rs12965856 chr18:31344080 A/G cg27147174 chr7:100797783 AP1S1 -0.47 -6.9 -0.35 2.61e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs6977660 0.507 rs4721822 chr7:19771693 T/C cg05791153 chr7:19748676 TWISTNB 0.87 8.99 0.44 1.82e-17 Thyroid stimulating hormone; LUSC cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg02153584 chr22:29168773 CCDC117 0.58 8.72 0.43 1.35e-16 Lymphocyte counts; LUSC cis rs3892630 0.878 rs7246451 chr19:33209614 C/G cg22980127 chr19:33182716 NUDT19 0.92 12.28 0.56 7.57e-29 Red blood cell traits; LUSC cis rs7589342 0.839 rs35812588 chr2:106432201 C/T cg16077055 chr2:106428750 NCK2 0.38 7.2 0.37 4.02e-12 Addiction; LUSC cis rs9534288 0.912 rs4941540 chr13:46604710 C/T cg15192986 chr13:46630673 CPB2 -0.74 -11.78 -0.54 4.87e-27 Blood protein levels; LUSC cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.36 0.37 1.42e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg19729930 chr2:74357872 NA 0.9 14.57 0.62 1.4e-37 Gestational age at birth (maternal effect); LUSC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -5.76 -0.3 1.88e-8 Personality dimensions; LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg06873352 chr17:61820015 STRADA 0.72 12.71 0.57 1.82e-30 Prudent dietary pattern; LUSC cis rs1160297 0.609 rs12622966 chr2:53078420 G/C cg07782112 chr2:53107842 NA 0.4 6.5 0.33 2.97e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg04362960 chr10:104952993 NT5C2 0.62 9.83 0.47 3.35e-20 Arsenic metabolism; LUSC cis rs7937682 0.575 rs34888817 chr11:111756455 C/T cg09085632 chr11:111637200 PPP2R1B 0.96 13.3 0.59 1.14e-32 Primary sclerosing cholangitis; LUSC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg15649852 chr7:65879115 NA 0.41 5.78 0.3 1.67e-8 Aortic root size; LUSC cis rs2219968 0.828 rs4412362 chr8:78930579 C/T cg00738934 chr8:78996279 NA -0.42 -7.56 -0.38 4.05e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs9921222 0.521 rs757460 chr16:367174 G/C cg15001381 chr16:403314 AXIN1 0.33 6.19 0.32 1.74e-9 Bone mineral density (spine);Bone mineral density; LUSC trans rs6076960 0.682 rs6054065 chr20:6267920 G/A cg24759859 chr6:86352639 SYNCRIP 0.41 6.09 0.32 3.17e-9 Smooth-surface caries; LUSC trans rs1493916 1.000 rs7238717 chr18:31395186 C/T cg13755796 chr4:20253514 NA -0.42 -6.46 -0.33 3.62e-10 Life satisfaction; LUSC cis rs7712401 0.562 rs2927639 chr5:122279666 G/C cg19077854 chr5:122220652 SNX24 0.41 9.17 0.45 4.86e-18 Mean platelet volume; LUSC cis rs7119038 0.774 rs10892290 chr11:118653503 G/T cg19308663 chr11:118741387 NA 0.39 6.64 0.34 1.25e-10 Sjögren's syndrome; LUSC cis rs250677 0.617 rs166106 chr5:148447061 T/C cg18129178 chr5:148520854 ABLIM3 -0.75 -10.93 -0.51 5.42e-24 Breast cancer; LUSC cis rs259282 0.605 rs17692992 chr19:33099430 T/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.66 9.83 0.47 3.45e-20 Schizophrenia; LUSC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg19901468 chr14:105411992 AHNAK2 -0.71 -12.26 -0.56 8.47e-29 Rheumatoid arthritis; LUSC cis rs7520050 0.898 rs4660885 chr1:46243756 C/T cg24296786 chr1:45957014 TESK2 0.42 5.95 0.31 6.67e-9 Red blood cell count;Reticulocyte count; LUSC cis rs6743226 0.901 rs7599888 chr2:242248033 C/G cg10021735 chr2:242295487 FARP2 -0.36 -5.65 -0.3 3.47e-8 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; LUSC trans rs208520 0.690 rs12213581 chr6:66735818 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.09 16.92 0.68 7.94e-47 Exhaled nitric oxide output; LUSC cis rs7267979 0.966 rs2482948 chr20:25296499 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.51 -0.34 2.68e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs534126 1.000 rs476826 chr7:142906434 C/T cg04039957 chr7:143013207 CLCN1 -0.31 -6.12 -0.32 2.66e-9 Cancer; LUSC trans rs2840044 0.534 rs321596 chr17:33885736 C/T cg19694781 chr19:47549865 TMEM160 0.42 6.84 0.35 3.86e-11 Response to radiotherapy in cancer (late toxicity); LUSC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg11764359 chr7:65958608 NA -0.77 -12.69 -0.57 2.12e-30 Aortic root size; LUSC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg15704280 chr7:45808275 SEPT13 1.0 18.55 0.71 2.78e-53 Height; LUSC cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.45 -8.18 -0.41 6.14e-15 Eosinophil percentage of white cells; LUSC trans rs12210905 1.000 rs7757680 chr6:27005840 T/C cg11837749 chr1:55047332 ACOT11 0.59 6.28 0.32 1.05e-9 Hip circumference adjusted for BMI; LUSC cis rs1775715 0.737 rs2808072 chr10:32205504 A/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.4e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs13392177 0.672 rs4674270 chr2:219053141 G/T cg00012203 chr2:219082015 ARPC2 -0.77 -13.08 -0.58 7.36e-32 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs3916 0.955 rs35599677 chr12:121141458 G/A cg27246729 chr12:121163418 ACADS 0.47 6.76 0.35 6.09e-11 Urinary metabolites (H-NMR features); LUSC cis rs1044826 1.000 rs9818691 chr3:139113199 C/T cg00490450 chr3:139108681 COPB2 0.58 7.71 0.39 1.45e-13 Obesity-related traits; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03352322 chr19:52693048 PPP2R1A 0.4 6.39 0.33 5.55e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg04727924 chr7:799746 HEATR2 -0.52 -6.39 -0.33 5.54e-10 Cerebrospinal P-tau181p levels; LUSC cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg23791538 chr6:167370224 RNASET2 -0.4 -6.37 -0.33 6.17e-10 Crohn's disease; LUSC cis rs34779708 0.966 rs12260130 chr10:35467671 C/T cg03585969 chr10:35415529 CREM 0.64 9.49 0.46 4.61e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.17e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.12 -0.36 6.47e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2871473 1.000 rs1030024 chr2:103105769 A/T cg09003973 chr2:102972529 NA -0.63 -7.21 -0.37 3.75e-12 Blood protein levels; LUSC trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg03929089 chr4:120376271 NA -0.6 -7.24 -0.37 3.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs7527798 0.592 rs2181694 chr1:207826776 G/A cg09232269 chr1:207846808 CR1L -0.3 -6.37 -0.33 6.19e-10 Erythrocyte sedimentation rate; LUSC cis rs7223966 1.000 rs9899788 chr17:61756384 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.33 0.37 1.75e-12 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19866445 chr5:271553 PDCD6 -0.39 -5.96 -0.31 6.35e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12579753 0.869 rs12366921 chr12:82223024 G/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.03 -0.31 4.24e-9 Resting heart rate; LUSC cis rs3771570 0.901 rs28433352 chr2:242339656 A/G cg21155796 chr2:242212141 HDLBP 0.52 6.31 0.33 8.9e-10 Prostate cancer; LUSC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs870825 0.616 rs4444872 chr4:185628405 A/G cg04058563 chr4:185651563 MLF1IP 0.87 12.96 0.58 2.17e-31 Blood protein levels; LUSC cis rs9788721 0.806 rs4887056 chr15:78734585 A/G cg18825076 chr15:78729989 IREB2 -0.59 -9.76 -0.47 5.72e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs34779708 1.000 rs34779708 chr10:35466185 T/G cg03585969 chr10:35415529 CREM 0.62 9.22 0.45 3.54e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6693567 0.565 rs11205370 chr1:150397567 A/G cg15654264 chr1:150340011 RPRD2 0.44 7.09 0.36 8.16e-12 Migraine; LUSC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg01851573 chr8:8652454 MFHAS1 0.36 5.69 0.3 2.83e-8 Schizophrenia; LUSC cis rs9814567 1.000 rs13087875 chr3:134261123 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg24642439 chr20:33292090 TP53INP2 0.53 8.1 0.41 1.03e-14 Coronary artery disease; LUSC cis rs6545883 0.929 rs2694625 chr2:61616055 G/A cg15711740 chr2:61764176 XPO1 0.44 6.69 0.34 9.61e-11 Tuberculosis; LUSC cis rs7246967 0.673 rs8106180 chr19:22879360 G/A cg23217946 chr19:22817039 ZNF492 0.47 6.46 0.33 3.69e-10 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs800082 0.690 rs2118001 chr3:144336609 T/C cg24215973 chr2:240111563 HDAC4 -0.58 -9.32 -0.45 1.58e-18 Smoking behavior; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg08472276 chr7:1133186 C7orf50;GPER -0.4 -6.56 -0.34 2.06e-10 Longevity;Endometriosis; LUSC cis rs11122272 0.735 rs2749716 chr1:231486908 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.86 0.47 2.61e-20 Hemoglobin concentration; LUSC cis rs9283706 0.595 rs6866433 chr5:66324152 A/G cg11590213 chr5:66331682 MAST4 0.47 7.51 0.38 5.52e-13 Coronary artery disease; LUSC cis rs9916302 0.706 rs8073907 chr17:37424149 C/T cg07936489 chr17:37558343 FBXL20 -0.8 -10.07 -0.48 5.09e-21 Glomerular filtration rate (creatinine); LUSC trans rs800082 0.516 rs1178893 chr3:144239246 A/C cg24215973 chr2:240111563 HDAC4 0.45 6.98 0.36 1.6e-11 Smoking behavior; LUSC cis rs259282 0.605 rs35728696 chr19:33108096 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.64 9.51 0.46 3.97e-19 Schizophrenia; LUSC cis rs4776059 0.724 rs8030141 chr15:52937689 G/A cg22715398 chr15:52968154 KIAA1370 0.58 7.25 0.37 3e-12 Schizophrenia; LUSC cis rs734999 0.566 rs4648563 chr1:2536002 C/G cg18854424 chr1:2615690 NA 0.5 9.97 0.48 1.12e-20 Ulcerative colitis; LUSC trans rs10822407 0.710 rs10822363 chr10:66650703 C/T cg26654559 chr16:86492912 NA 0.34 5.98 0.31 5.64e-9 Diastolic blood pressure; LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg06145435 chr7:1022769 CYP2W1 0.29 6.25 0.32 1.24e-9 Longevity;Endometriosis; LUSC cis rs7666738 0.546 rs7679681 chr4:98882221 A/G cg05340658 chr4:99064831 C4orf37 0.59 8.75 0.43 1.04e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs10779751 1.000 rs2300093 chr1:11266392 G/C cg08854313 chr1:11322531 MTOR 0.91 16.32 0.67 1.93e-44 Body mass index; LUSC cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.58 -0.6 9.45e-34 Chronic sinus infection; LUSC cis rs8078723 0.690 rs3785549 chr17:38149724 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.37 0.37 1.39e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7618501 1.000 rs9859153 chr3:49807085 G/T cg13072238 chr3:49761600 GMPPB 0.39 6.43 0.33 4.47e-10 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg00316803 chr15:76480434 C15orf27 -0.41 -6.96 -0.36 1.77e-11 Blood metabolite levels; LUSC cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg10978503 chr1:24200527 CNR2 -0.47 -9.65 -0.47 1.32e-19 Immature fraction of reticulocytes; LUSC trans rs17685 0.753 rs12531559 chr7:75631697 C/T cg19862616 chr7:65841803 NCRNA00174 -1.13 -19.86 -0.74 1.64e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -7.35 -0.37 1.53e-12 Renal function-related traits (BUN); LUSC cis rs548181 0.736 rs556884 chr11:125550049 G/A cg03464685 chr11:125439445 EI24 1.22 14.52 0.62 2.22e-37 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Vitiligo; LUSC cis rs2279817 0.735 rs71644063 chr1:17987274 A/G cg21791023 chr1:18019539 ARHGEF10L -0.48 -5.73 -0.3 2.3e-8 Neuroticism; LUSC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg11632617 chr15:75315747 PPCDC -0.54 -7.12 -0.36 6.84e-12 Blood trace element (Zn levels); LUSC cis rs870825 0.655 rs12502771 chr4:185635834 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.23 0.59 2.05e-32 Blood protein levels; LUSC trans rs2898290 0.622 rs978804 chr8:11343673 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.56 -0.42 4.14e-16 Systolic blood pressure; LUSC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.54e-21 Electroencephalogram traits; LUSC cis rs2072499 0.767 rs3001789 chr1:156197614 T/G cg24450063 chr1:156163899 SLC25A44 1.1 21.87 0.77 2.05e-66 Testicular germ cell tumor; LUSC cis rs68170813 0.559 rs1548523 chr7:106944408 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.72 -0.47 7.9e-20 Coronary artery disease; LUSC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg04414720 chr1:150670196 GOLPH3L 0.54 8.46 0.42 8.59e-16 Melanoma; LUSC cis rs72781680 1.000 rs72798408 chr2:24181845 G/C cg08917208 chr2:24149416 ATAD2B 1.01 10.6 0.5 8.3300000000000006e-23 Lymphocyte counts; LUSC cis rs6556937 0.562 rs26485 chr5:96016477 C/T cg07690455 chr5:95997198 CAST 0.42 5.91 0.31 8.29e-9 Blood protein levels; LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1003719 0.612 rs2835652 chr21:38557408 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.41 -0.49 3.71e-22 Eye color traits; LUSC cis rs2279817 1.000 rs905389 chr1:18021406 T/C cg21791023 chr1:18019539 ARHGEF10L 0.48 6.74 0.35 7.09e-11 Neuroticism; LUSC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg09267113 chr7:98030324 BAIAP2L1 0.38 5.78 0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg05855489 chr10:104503620 C10orf26 0.61 9.8 0.47 4.43e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg15704280 chr7:45808275 SEPT13 0.66 7.35 0.37 1.58e-12 Axial length; LUSC cis rs981844 1.000 rs2606327 chr4:154653629 C/T cg14289246 chr4:154710475 SFRP2 0.53 6.83 0.35 4.06e-11 Response to statins (LDL cholesterol change); LUSC trans rs11764590 0.950 rs11514731 chr7:2051503 C/G cg11693508 chr17:37793320 STARD3 0.56 6.66 0.34 1.12e-10 Neuroticism; LUSC cis rs6693567 0.545 rs11205382 chr1:150442466 G/A cg15654264 chr1:150340011 RPRD2 -0.44 -7.1 -0.36 7.31e-12 Migraine; LUSC cis rs7804356 0.861 rs114236648 chr7:26874639 A/G cg03456212 chr7:26904342 SKAP2 -0.55 -6.37 -0.33 6.29e-10 Type 1 diabetes; LUSC cis rs477692 1.000 rs473073 chr10:131429646 G/T cg05714579 chr10:131428358 MGMT 0.51 7.54 0.38 4.54e-13 Response to temozolomide; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19607838 chr20:43594981 STK4 -0.45 -6.8 -0.35 4.7e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9611519 0.929 rs9611474 chr22:41434858 G/A cg03806693 chr22:41940476 POLR3H -0.51 -6.93 -0.35 2.17e-11 Neuroticism; LUSC cis rs7264396 0.635 rs6060688 chr20:34516731 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.6 8.84 0.44 5.58e-17 Total cholesterol levels; LUSC trans rs2243480 1.000 rs1039664 chr7:65449716 T/G cg10756647 chr7:56101905 PSPH 0.86 8.39 0.42 1.36e-15 Diabetic kidney disease; LUSC cis rs4595586 0.545 rs4768526 chr12:39402898 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.01 0.31 4.92e-9 Morning vs. evening chronotype; LUSC trans rs7615952 0.673 rs9821905 chr3:125620850 A/G cg07211511 chr3:129823064 LOC729375 1.0 12.96 0.58 2.06e-31 Blood pressure (smoking interaction); LUSC cis rs10875746 0.903 rs11168401 chr12:48481519 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs2219968 1.000 rs2128014 chr8:78963292 T/C cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3845702 0.736 rs72960664 chr2:180832672 C/T cg01881094 chr2:180872142 CWC22 1.06 12.67 0.57 2.59e-30 Schizophrenia; LUSC cis rs17255340 0.539 rs1170518 chr6:84011913 T/C cg08257003 chr6:84140564 ME1 0.32 7.71 0.39 1.44e-13 Platelet-derived growth factor BB levels; LUSC cis rs11122272 0.705 rs2486731 chr1:231532511 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.59 9.33 0.45 1.57e-18 Hemoglobin concentration; LUSC cis rs887829 0.569 rs10179091 chr2:234657983 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -8.79 -0.43 7.88e-17 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs877282 0.583 rs7072970 chr10:822757 G/A cg13042288 chr15:90349979 ANPEP -0.41 -5.99 -0.31 5.3300000000000004e-09 Uric acid levels; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg18477163 chr1:228402036 OBSCN 0.62 12.2 0.56 1.49e-28 Diastolic blood pressure; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg09177884 chr7:1199841 ZFAND2A -0.63 -9.23 -0.45 3.29e-18 Longevity;Endometriosis; LUSC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg11764359 chr7:65958608 NA 0.68 10.99 0.52 3.57e-24 Aortic root size; LUSC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg10792982 chr14:105748885 BRF1 0.52 9.54 0.46 3e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs9902453 0.904 rs9897794 chr17:28296327 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.6 0.5 7.9399999999999994e-23 Coffee consumption (cups per day); LUSC cis rs939658 0.805 rs11638004 chr15:79425765 A/C cg17916960 chr15:79447300 NA -0.53 -10.45 -0.5 2.58e-22 Refractive error; LUSC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg16405210 chr4:1374714 KIAA1530 -0.53 -8.02 -0.4 1.84e-14 Obesity-related traits; LUSC cis rs6051080 1 rs6051080 chr20:25975674 A/G cg13962466 chr20:25176127 ENTPD6 0.52 8.51 0.42 5.91e-16 Colorectal or endometrial cancer; LUSC cis rs2439831 1.000 rs565007 chr15:43716641 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.98 11.3 0.53 2.63e-25 Lung cancer in ever smokers; LUSC cis rs7799006 0.593 rs12531150 chr7:2289888 C/T cg08027265 chr7:2291960 NA -0.63 -11.37 -0.53 1.47e-25 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg12963246 chr6:28129442 ZNF389 0.53 7.35 0.37 1.54e-12 Parkinson's disease; LUSC trans rs6502050 0.835 rs8071425 chr17:80117335 C/T cg07393940 chr7:158741817 NA -0.34 -6.06 -0.31 3.58e-9 Life satisfaction; LUSC cis rs262150 0.592 rs56062559 chr7:158769109 T/C cg19418458 chr7:158789849 NA 0.58 7.18 0.37 4.59e-12 Facial morphology (factor 20); LUSC cis rs7590368 0.683 rs56344711 chr2:10969688 C/T cg15705551 chr2:10952987 PDIA6 0.62 6.71 0.34 8.52e-11 Educational attainment (years of education); LUSC cis rs2282032 1.000 rs3742671 chr14:90756760 A/T cg14092571 chr14:90743983 NA 0.56 7.13 0.36 6.3e-12 Longevity; LUSC trans rs800082 1.000 rs4681363 chr3:144287355 A/G cg24215973 chr2:240111563 HDAC4 -0.45 -6.7 -0.34 8.75e-11 Smoking behavior; LUSC cis rs765787 0.530 rs11070444 chr15:45513121 T/C cg24006582 chr15:45444508 DUOX1 0.67 9.67 0.47 1.16e-19 Uric acid levels; LUSC cis rs62400317 0.826 rs12216308 chr6:45342305 T/G cg20913747 chr6:44695427 NA -0.49 -8.0 -0.4 2.02e-14 Total body bone mineral density; LUSC cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg15423357 chr2:25149977 NA 0.4 7.93 0.4 3.24e-14 Body mass index; LUSC cis rs3809566 1.000 rs10851721 chr15:63332383 T/C cg00520135 chr15:63333846 TPM1 -0.34 -6.79 -0.35 5.15e-11 Platelet count; LUSC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg22535103 chr8:58192502 C8orf71 -0.58 -6.94 -0.36 2e-11 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02905964 chr19:29704262 UQCRFS1 0.43 6.47 0.33 3.53e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6704768 0.545 rs5004510 chr2:233679275 A/C cg08000102 chr2:233561755 GIGYF2 -0.78 -12.38 -0.56 3.18e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs11098499 0.863 rs7657849 chr4:120455494 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg12011299 chr4:100065546 ADH4 -0.69 -10.87 -0.51 9.4e-24 Alcohol dependence; LUSC cis rs67981189 0.593 rs9806042 chr14:71530993 G/C cg15816911 chr14:71606274 NA 0.33 5.85 0.3 1.19e-8 Schizophrenia; LUSC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg03709012 chr19:19516395 GATAD2A -0.83 -13.84 -0.6 9.33e-35 Tonsillectomy; LUSC cis rs992157 0.710 rs56364928 chr2:219059058 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.49 7.61 0.38 2.78e-13 Colorectal cancer; LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg06600287 chr1:53387719 ECHDC2 -0.31 -6.41 -0.33 5.09e-10 Monocyte count; LUSC cis rs12980942 0.872 rs16958994 chr19:41824981 T/C cg25627403 chr19:41769009 HNRNPUL1 0.55 5.94 0.31 7.27e-9 Coronary artery disease; LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.39 5.69 0.3 2.78e-8 Renal function-related traits (BUN); LUSC cis rs11971779 0.650 rs10085842 chr7:139064582 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs6964587 0.935 rs9770444 chr7:91783162 T/G cg17063962 chr7:91808500 NA 0.6 9.54 0.46 3.18e-19 Breast cancer; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg12419862 chr22:24373484 LOC391322 -0.95 -18.01 -0.7 3.81e-51 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg17252645 chr8:143867129 LY6D 0.38 6.72 0.34 8.03e-11 Urinary tract infection frequency; LUSC cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg26384229 chr12:38710491 ALG10B -0.87 -15.19 -0.64 5.53e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg26335602 chr6:28129616 ZNF389 -0.45 -6.28 -0.33 1.05e-9 Depression; LUSC cis rs9815354 0.812 rs111967505 chr3:41873157 C/T cg03022575 chr3:42003672 ULK4 0.84 8.86 0.44 4.79e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg16434002 chr17:42200994 HDAC5 -0.44 -6.0 -0.31 5.26e-9 Total body bone mineral density; LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg05025164 chr4:1340916 KIAA1530 0.43 6.64 0.34 1.26e-10 Longevity; LUSC trans rs853679 0.517 rs9393896 chr6:28127703 C/T cg06606381 chr12:133084897 FBRSL1 -0.46 -6.19 -0.32 1.76e-9 Depression; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C ch.6.143706070F chr6:143664377 NA 0.33 6.06 0.31 3.67e-9 Tuberculosis; LUSC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg06238570 chr21:40685208 BRWD1 0.5 7.5 0.38 5.85e-13 Cognitive function; LUSC cis rs8077889 0.917 rs72836556 chr17:41911824 G/T cg26893861 chr17:41843967 DUSP3 0.94 14.36 0.62 9.27e-37 Triglycerides; LUSC cis rs72781680 1.000 rs72781683 chr2:24247423 T/C cg20701182 chr2:24300061 SF3B14 0.76 7.7 0.39 1.51e-13 Lymphocyte counts; LUSC cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg26647111 chr11:31128758 NA -0.43 -6.12 -0.32 2.58e-9 Red blood cell count; LUSC cis rs524023 0.958 rs12802649 chr11:64359627 C/T cg07220939 chr11:64358617 SLC22A12 -0.22 -5.69 -0.3 2.76e-8 Urate levels in obese individuals; LUSC cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg04455712 chr21:45112962 RRP1B 0.48 8.87 0.44 4.6e-17 Mean corpuscular volume; LUSC cis rs7005380 0.556 rs12548248 chr8:120932321 A/G cg21744203 chr8:120868354 DSCC1 -0.47 -5.75 -0.3 1.97e-8 Interstitial lung disease; LUSC cis rs9361491 0.508 rs7773448 chr6:79417356 C/T cg05283184 chr6:79620031 NA -0.39 -6.88 -0.35 2.88e-11 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03156032 chr17:27717754 TAOK1 -0.41 -6.22 -0.32 1.45e-9 Electrocardiographic conduction measures; LUSC cis rs9929218 0.906 rs34565494 chr16:68741769 C/T cg02972257 chr16:68554789 NA 0.46 5.9 0.31 9.01e-9 Colorectal cancer; LUSC cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.75 -0.35 6.5e-11 Monocyte percentage of white cells; LUSC cis rs10791323 0.519 rs329663 chr11:133754543 A/G cg15485101 chr11:133734466 NA 0.38 7.15 0.36 5.64e-12 Childhood ear infection; LUSC cis rs6500602 0.727 rs7193136 chr16:4580034 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 7.78 0.39 8.86e-14 Schizophrenia; LUSC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.49 -0.53 5.69e-26 Schizophrenia; LUSC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs3087591 0.708 rs2854307 chr17:29652147 G/A cg24425628 chr17:29625626 OMG;NF1 0.46 6.93 0.35 2.21e-11 Hip circumference; LUSC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg12310025 chr6:25882481 NA -0.5 -8.38 -0.42 1.5e-15 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg18765753 chr7:1198926 ZFAND2A -0.35 -6.07 -0.32 3.4e-9 Longevity;Endometriosis; LUSC cis rs9486715 1.000 rs9486715 chr6:97059769 A/C cg06623918 chr6:96969491 KIAA0776 -0.86 -14.29 -0.62 1.69e-36 Headache; LUSC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.08 0.32 3.34e-9 Menopause (age at onset); LUSC cis rs7267979 0.668 rs2387977 chr20:25599776 C/T cg03522245 chr20:25566470 NINL -0.4 -6.47 -0.33 3.59e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1790761 0.692 rs638140 chr11:67333858 G/C cg00864171 chr11:67383662 NA 0.34 5.97 0.31 5.93e-9 Mean corpuscular volume; LUSC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg06112835 chr11:68658793 MRPL21 0.49 7.47 0.38 7.02e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.08 0.44 9.59e-18 Motion sickness; LUSC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6062509 0.965 rs6062504 chr20:62348907 A/G cg01176363 chr20:62369445 LIME1 -0.47 -7.14 -0.36 5.85e-12 Prostate cancer; LUSC cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 10.74 0.51 2.71e-23 Chronic sinus infection; LUSC cis rs921665 0.680 rs7591433 chr2:3180126 A/C cg02624386 chr2:3182749 NA 0.6 6.69 0.34 9.7e-11 World class endurance athleticism; LUSC cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg27129171 chr3:47204927 SETD2 -0.69 -11.58 -0.54 2.66e-26 Colorectal cancer; LUSC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg03161606 chr19:29218774 NA 0.63 9.73 0.47 7.39e-20 Methadone dose in opioid dependence; LUSC cis rs9309473 0.950 rs6546858 chr2:73838613 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.63 -0.34 1.37e-10 Metabolite levels; LUSC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg26597838 chr10:835615 NA -0.42 -6.13 -0.32 2.48e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs11608355 0.521 rs4766595 chr12:109846998 A/T cg19025524 chr12:109796872 NA -0.4 -7.33 -0.37 1.73e-12 Neuroticism; LUSC cis rs4834770 1.000 rs2282688 chr4:120243722 T/C cg24375607 chr4:120327624 NA 0.41 5.84 0.3 1.26e-8 Blood protein levels; LUSC trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg03929089 chr4:120376271 NA 0.69 7.72 0.39 1.4e-13 Axial length; LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg21782813 chr7:2030301 MAD1L1 0.54 9.26 0.45 2.61e-18 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.909 rs1075698 chr20:30387992 G/C cg13852791 chr20:30311386 BCL2L1 0.87 11.6 0.54 2.35e-26 Mean corpuscular hemoglobin; LUSC cis rs2439831 0.867 rs2255051 chr15:43846161 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.75 7.57 0.38 3.64e-13 Lung cancer in ever smokers; LUSC cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg05535760 chr7:792225 HEATR2 0.75 8.8 0.43 7.39e-17 Cerebrospinal P-tau181p levels; LUSC cis rs77140172 0.655 rs79387006 chr4:89672775 A/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.96 7.68 0.39 1.82e-13 Post bronchodilator FEV1; LUSC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg02038168 chr22:39784481 NA -0.49 -8.11 -0.41 9.96e-15 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg02187348 chr16:89574699 SPG7 0.64 10.5 0.5 1.8e-22 Multiple myeloma (IgH translocation); LUSC cis rs11190604 1.000 rs2295772 chr10:102265183 G/A cg23241863 chr10:102295624 HIF1AN 0.5 5.98 0.31 5.63e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg18404041 chr3:52824283 ITIH1 -0.57 -11.01 -0.52 2.85e-24 Bipolar disorder; LUSC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.64 0.43 2.34e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg06462663 chr19:18546047 ISYNA1 -0.45 -7.66 -0.39 2.02e-13 Breast cancer; LUSC cis rs11031096 0.666 rs1662173 chr11:4127649 C/G cg18678763 chr11:4115507 RRM1 0.38 5.7 0.3 2.67e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg07703079 chr11:430292 ANO9 0.64 6.7 0.34 8.97e-11 Body mass index; LUSC cis rs9790314 0.846 rs6768818 chr3:160951648 A/G cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 4.11e-20 Morning vs. evening chronotype; LUSC cis rs17270561 0.609 rs4711103 chr6:25742224 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.62e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs4853525 1.000 rs4853525 chr2:191737464 T/C cg11845111 chr2:191398756 TMEM194B -0.4 -5.98 -0.31 5.65e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs12776158 0.591 rs12769200 chr10:71217784 A/G cg12610070 chr10:71211762 TSPAN15 0.35 5.7 0.3 2.67e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg12311346 chr5:56204834 C5orf35 -0.83 -12.93 -0.58 2.74e-31 Coronary artery disease; LUSC cis rs61931739 0.534 rs1844526 chr12:34102780 G/A cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs4474465 1.000 rs11604969 chr11:78179293 C/T cg27205649 chr11:78285834 NARS2 0.47 5.65 0.3 3.38e-8 Alzheimer's disease (survival time); LUSC cis rs4588572 0.643 rs13359053 chr5:77690224 T/C cg11547950 chr5:77652471 NA 0.53 7.46 0.38 7.57e-13 Triglycerides; LUSC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg14895029 chr7:2775587 GNA12 -0.4 -6.5 -0.34 2.94e-10 Height; LUSC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.1 0.58 6.37e-32 Total body bone mineral density; LUSC cis rs2717559 0.542 rs2717560 chr8:143881670 G/A cg07661805 chr8:143867942 LY6D -0.26 -5.95 -0.31 6.81e-9 Urinary tract infection frequency; LUSC cis rs10465746 0.967 rs10493744 chr1:84444752 C/T cg10977910 chr1:84465055 TTLL7 -0.45 -6.53 -0.34 2.48e-10 Obesity-related traits; LUSC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg00933542 chr6:150070202 PCMT1 0.3 6.05 0.31 3.79e-9 Lung cancer; LUSC trans rs7819412 0.540 rs2409725 chr8:11041661 T/C cg15556689 chr8:8085844 FLJ10661 -0.5 -7.02 -0.36 1.25e-11 Triglycerides; LUSC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg26373071 chr5:1325741 CLPTM1L -0.47 -8.99 -0.44 1.86e-17 Lung cancer; LUSC cis rs7584330 0.554 rs113271883 chr2:238425594 A/G cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.63e-9 Prostate cancer; LUSC cis rs2242116 0.592 rs6442039 chr3:46960797 C/G cg02527881 chr3:46936655 PTH1R -0.57 -8.42 -0.42 1.12e-15 Birth weight; LUSC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg04539111 chr16:67997858 SLC12A4 -0.46 -6.22 -0.32 1.52e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.41e-28 Motion sickness; LUSC cis rs2481665 0.772 rs12730782 chr1:62537265 A/G cg18591186 chr1:62594603 INADL -0.42 -6.51 -0.34 2.82e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6088580 0.524 rs6088575 chr20:33273403 C/T cg07148914 chr20:33460835 GGT7 0.53 8.11 0.41 9.72e-15 Glomerular filtration rate (creatinine); LUSC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg06212747 chr3:49208901 KLHDC8B 0.44 5.99 0.31 5.3e-9 Parkinson's disease; LUSC cis rs11758351 0.587 rs10484436 chr6:26237155 C/T cg23601095 chr6:26197514 HIST1H3D 0.68 7.3 0.37 2.16e-12 Gout;Renal underexcretion gout; LUSC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.46 6.75 0.35 6.52e-11 Eosinophil percentage of white cells; LUSC cis rs16854884 0.558 rs60367530 chr3:143719294 G/A cg06585982 chr3:143692056 C3orf58 0.45 6.9 0.35 2.61e-11 Economic and political preferences (feminism/equality); LUSC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg09021430 chr5:549028 NA -0.54 -7.03 -0.36 1.2e-11 Lung disease severity in cystic fibrosis; LUSC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg18876405 chr7:65276391 NA -0.58 -9.51 -0.46 4.03e-19 Aortic root size; LUSC cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg04861640 chr6:28234605 ZNF187 0.4 7.12 0.36 6.45e-12 Tuberculosis; LUSC cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg06784218 chr1:46089804 CCDC17 0.48 9.5 0.46 4.15e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7719624 1.000 rs2107331 chr5:135377349 A/C cg12897067 chr5:135418308 NA -0.4 -6.05 -0.31 3.83e-9 Response to cytidine analogues (gemcitabine); LUSC cis rs7000551 0.725 rs2461483 chr8:22386479 C/T cg12081754 chr8:22256438 SLC39A14 0.43 6.47 0.33 3.56e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1124376 0.688 rs11715447 chr3:20140129 A/C cg05072819 chr3:20081367 KAT2B 0.97 9.43 0.46 7.39e-19 Bipolar disorder and schizophrenia; LUSC cis rs2820315 0.965 rs8028 chr1:201865763 A/G cg10061532 chr1:201886748 LMOD1 -0.27 -6.1 -0.32 2.95e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.62 0.38 2.6e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs17828380 0.920 rs17828224 chr15:63456749 T/C cg05507819 chr15:63340323 TPM1 -0.75 -6.14 -0.32 2.35e-9 Social communication problems; LUSC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg27170947 chr2:26402098 FAM59B 0.6 8.19 0.41 5.66e-15 Gut microbiome composition (summer); LUSC cis rs10088262 0.629 rs6990565 chr8:124785645 C/A cg20713898 chr8:124780851 FAM91A1 -0.52 -7.32 -0.37 1.81e-12 Pancreatic cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22328890 chr16:68298258 SLC7A6 0.48 6.65 0.34 1.21e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg08499158 chr17:42289980 UBTF -0.48 -7.79 -0.39 8.46e-14 Total body bone mineral density; LUSC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg06481639 chr22:41940642 POLR3H -0.55 -6.6 -0.34 1.65e-10 Vitiligo; LUSC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00934597 chr7:893267 UNC84A -0.47 -7.12 -0.36 6.61e-12 Perceived unattractiveness to mosquitoes; LUSC cis rs6960043 0.818 rs10487796 chr7:15063430 T/A cg19272540 chr7:15055459 NA 0.33 8.01 0.4 1.91e-14 Type 2 diabetes; LUSC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg13628971 chr7:2884303 GNA12 0.44 6.21 0.32 1.57e-9 Height; LUSC cis rs2732480 0.538 rs1387259 chr12:48703522 C/T cg04545296 chr12:48745243 ZNF641 -0.37 -6.74 -0.35 6.81e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg06634786 chr22:41940651 POLR3H 0.5 6.04 0.31 4.07e-9 Vitiligo; LUSC trans rs2679649 1.000 rs1357056 chr6:122363734 C/T cg00167820 chr8:131663355 NA -0.46 -6.07 -0.32 3.42e-9 Subcutaneous adipose tissue; LUSC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg04518342 chr5:131593106 PDLIM4 0.34 6.35 0.33 6.96e-10 Blood metabolite levels; LUSC cis rs11122272 0.735 rs2739510 chr1:231526718 T/C cg06096015 chr1:231504339 EGLN1 0.57 9.93 0.48 1.56e-20 Hemoglobin concentration; LUSC trans rs3808502 0.549 rs4841564 chr8:11425809 T/G cg15556689 chr8:8085844 FLJ10661 -0.62 -9.23 -0.45 3.12e-18 Neuroticism; LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg14456004 chr13:21872349 NA 0.45 6.63 0.34 1.37e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg17173187 chr15:85201210 NMB 0.37 6.66 0.34 1.12e-10 Schizophrenia; LUSC cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg23583168 chr7:148888333 NA -0.88 -16.5 -0.67 3.72e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11122272 0.735 rs2808595 chr1:231526238 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.93 -0.48 1.61e-20 Hemoglobin concentration; LUSC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg26513180 chr16:89883248 FANCA 0.78 6.39 0.33 5.68e-10 Skin colour saturation; LUSC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs35110281 0.627 rs1836855 chr21:44965414 C/G cg04455712 chr21:45112962 RRP1B 0.47 9.07 0.44 1.06e-17 Mean corpuscular volume; LUSC cis rs2734839 0.964 rs2734838 chr11:113286501 A/G cg14159747 chr11:113255604 NA 0.27 6.83 0.35 4.03e-11 Information processing speed; LUSC cis rs716595 1.000 rs72830456 chr10:112008631 G/A cg13996003 chr10:112034540 MXI1 -0.7 -5.68 -0.3 2.96e-8 Normalized brain volume; LUSC cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg12011299 chr4:100065546 ADH4 -0.69 -10.77 -0.51 2.13e-23 Alcohol dependence; LUSC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg09455208 chr3:40491958 NA 0.56 10.19 0.49 2.09e-21 Renal cell carcinoma; LUSC cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg24642439 chr20:33292090 TP53INP2 0.74 12.11 0.55 3.11e-28 Coronary artery disease; LUSC cis rs10465746 0.935 rs11807807 chr1:84424071 C/T cg10977910 chr1:84465055 TTLL7 0.42 6.21 0.32 1.59e-9 Obesity-related traits; LUSC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg03526776 chr6:41159608 TREML2 0.33 6.12 0.32 2.67e-9 Alzheimer's disease (late onset); LUSC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg12311346 chr5:56204834 C5orf35 -0.63 -9.14 -0.45 6.15e-18 Coronary artery disease; LUSC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg05425664 chr17:57184151 TRIM37 -0.56 -8.26 -0.41 3.37e-15 Intelligence (multi-trait analysis); LUSC cis rs7590368 0.673 rs55648622 chr2:10932765 C/T cg15705551 chr2:10952987 PDIA6 0.52 5.86 0.31 1.13e-8 Educational attainment (years of education); LUSC cis rs4494114 1.000 rs10890491 chr1:39354602 G/A cg25970120 chr1:39325951 RRAGC -0.4 -6.19 -0.32 1.8e-9 Blood protein levels; LUSC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg18681998 chr4:17616180 MED28 0.84 15.29 0.64 2.27e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs561341 0.714 rs55925849 chr17:30253085 C/T cg27661571 chr11:113659931 NA -0.66 -7.51 -0.38 5.31e-13 Hip circumference adjusted for BMI; LUSC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg18876405 chr7:65276391 NA -0.56 -8.95 -0.44 2.53e-17 Aortic root size; LUSC cis rs11122272 0.735 rs2486729 chr1:231535584 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.03 0.48 7.06e-21 Hemoglobin concentration; LUSC cis rs1595825 0.735 rs113834557 chr2:198611624 A/G cg00982548 chr2:198649783 BOLL -0.59 -7.27 -0.37 2.63e-12 Ulcerative colitis; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg16647868 chr5:131706066 SLC22A5 0.35 5.95 0.31 6.8e-9 Blood metabolite levels; LUSC cis rs12368653 0.584 rs7295422 chr12:58099736 G/A cg18357645 chr12:58087776 OS9 0.43 6.47 0.33 3.48e-10 Multiple sclerosis; LUSC cis rs7312933 0.501 rs7296357 chr12:42729891 T/G cg01256987 chr12:42539512 GXYLT1 0.34 6.23 0.32 1.39e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2970818 0.764 rs11063171 chr12:4576775 C/G cg11146114 chr12:4671731 NA -0.65 -6.31 -0.33 9.06e-10 Phosphorus levels; LUSC cis rs7575217 0.849 rs7571554 chr2:101769917 T/G cg23907051 chr2:101730305 TBC1D8 -0.29 -7.47 -0.38 7.26e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.89 -0.31 9.59e-9 Tonsillectomy; LUSC cis rs9612 1.000 rs2074634 chr19:44238347 C/T cg08581076 chr19:44259116 C19orf61 -0.52 -6.46 -0.33 3.62e-10 Exhaled nitric oxide output; LUSC cis rs2200578 1.000 rs72954221 chr2:99899445 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.48 0.33 3.26e-10 IgG glycosylation; LUSC trans rs2048656 0.570 rs7814635 chr8:9646620 G/A cg06636001 chr8:8085503 FLJ10661 0.46 6.52 0.34 2.64e-10 Schizophrenia; LUSC trans rs7618501 0.633 rs2526751 chr3:50064867 T/C cg21659725 chr3:3221576 CRBN -0.64 -10.69 -0.5 3.96e-23 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs11148252 0.553 rs2147692 chr13:53287023 C/G cg02158880 chr13:53174818 NA 0.57 9.95 0.48 1.39e-20 Lewy body disease; LUSC cis rs868036 0.881 rs12708496 chr15:68054098 T/C cg05925327 chr15:68127851 NA 0.33 5.94 0.31 7.06e-9 Restless legs syndrome; LUSC cis rs35828350 1 rs35828350 chr15:85355841 G/A cg12863693 chr15:85201151 NMB 0.42 8.43 0.42 1.05e-15 Autism spectrum disorder or schizophrenia; LUSC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg17971929 chr21:40555470 PSMG1 -0.67 -11.24 -0.52 4.52e-25 Cognitive function; LUSC trans rs61931739 0.500 rs11053243 chr12:34514155 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.19e-33 Morning vs. evening chronotype; LUSC trans rs7618501 0.633 rs2526748 chr3:50080439 A/G cg21659725 chr3:3221576 CRBN -0.63 -10.4 -0.49 4.05e-22 Intelligence (multi-trait analysis); LUSC cis rs897984 0.762 rs12931046 chr16:30987144 G/A cg02466173 chr16:30829666 NA 0.55 10.88 0.51 8.73e-24 Dementia with Lewy bodies; LUSC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 11.96 0.55 1.09e-27 Hip circumference adjusted for BMI; LUSC cis rs727505 1.000 rs10228201 chr7:124449895 A/G cg23710748 chr7:124431027 NA -0.42 -7.58 -0.38 3.53e-13 Lewy body disease; LUSC trans rs6598955 0.671 rs17163866 chr1:26648088 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.66 -8.34 -0.42 2.03e-15 Obesity-related traits; LUSC cis rs79149102 0.579 rs7342591 chr15:75306863 C/T cg17294928 chr15:75287854 SCAMP5 0.7 6.38 0.33 5.79e-10 Lung cancer; LUSC trans rs1941687 0.509 rs6507060 chr18:31322278 C/T cg27147174 chr7:100797783 AP1S1 0.53 8.32 0.41 2.32e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg27129171 chr3:47204927 SETD2 -0.57 -8.16 -0.41 7.07e-15 Birth weight; LUSC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg03676636 chr4:99064102 C4orf37 -0.33 -7.49 -0.38 6.06e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7945718 0.839 rs2033908 chr11:12838286 G/T cg25843174 chr11:12811716 TEAD1 0.32 7.36 0.37 1.49e-12 Educational attainment (years of education); LUSC cis rs9300255 0.739 rs4759371 chr12:123742563 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.43 0.33 4.29e-10 Neutrophil percentage of white cells; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg10150615 chr22:24372951 LOC391322 -0.38 -6.43 -0.33 4.44e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs9929218 0.817 rs8055912 chr16:68802068 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -12.13 -0.55 2.7e-28 Colorectal cancer; LUSC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg14893161 chr1:205819251 PM20D1 -0.46 -6.5 -0.34 2.9e-10 Parkinson's disease; LUSC cis rs62408225 0.802 rs2325261 chr6:90921407 T/C cg06866423 chr6:90926672 BACH2 0.44 6.83 0.35 3.91e-11 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6591341 0.515 rs599301 chr11:68189945 G/C cg16797656 chr11:68205561 LRP5 0.46 8.14 0.41 7.92e-15 Lean body mass; LUSC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg18654377 chr3:49208889 KLHDC8B -0.43 -5.7 -0.3 2.7e-8 Menarche (age at onset); LUSC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.58 7.59 0.38 3.33e-13 Lung function (FEV1/FVC); LUSC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg11645453 chr3:52864694 ITIH4 0.34 7.99 0.4 2.19e-14 Electroencephalogram traits; LUSC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs477692 0.967 rs519690 chr10:131424033 G/A cg05714579 chr10:131428358 MGMT 0.5 7.43 0.38 9.36e-13 Response to temozolomide; LUSC cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.98e-12 Motion sickness; LUSC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.83 0.44 6.01e-17 Schizophrenia; LUSC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11890956 chr21:40555474 PSMG1 -0.66 -9.62 -0.47 1.65e-19 Menarche (age at onset); LUSC cis rs11098499 0.820 rs28535956 chr4:120536858 C/T cg24375607 chr4:120327624 NA -0.73 -10.77 -0.51 2.09e-23 Corneal astigmatism; LUSC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg01475377 chr6:109611718 NA -0.37 -6.55 -0.34 2.22e-10 Reticulocyte fraction of red cells; LUSC cis rs4851254 1.000 rs4851254 chr2:100762937 C/G cg07810366 chr2:100720526 AFF3 -0.36 -5.66 -0.3 3.21e-8 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg12016809 chr21:47604291 C21orf56 0.39 5.69 0.3 2.81e-8 Testicular germ cell tumor; LUSC cis rs2877187 0.511 rs9639867 chr7:43038272 A/G cg00365680 chr7:42972339 MRPL32;PSMA2 -0.44 -5.89 -0.31 9.29e-9 Lung cancer in ever smokers; LUSC cis rs7560272 0.723 rs62153184 chr2:73773869 G/C cg20560298 chr2:73613845 ALMS1 -0.48 -7.43 -0.38 9.41e-13 Schizophrenia; LUSC cis rs701145 0.585 rs1542254 chr3:153864296 C/T cg17054900 chr3:154042577 DHX36 0.63 6.18 0.32 1.9e-9 Coronary artery disease; LUSC trans rs804280 0.565 rs1466785 chr8:11623456 C/T cg15556689 chr8:8085844 FLJ10661 0.44 6.09 0.32 3.15e-9 Myopia (pathological); LUSC cis rs7089973 0.872 rs36036948 chr10:116631649 A/G cg23260525 chr10:116636907 FAM160B1 0.38 7.77 0.39 9.94e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg02569458 chr12:86230093 RASSF9 0.58 9.85 0.47 2.89e-20 Major depressive disorder; LUSC trans rs7618501 0.521 rs2883059 chr3:49902160 C/T cg21659725 chr3:3221576 CRBN -0.61 -9.98 -0.48 1.05e-20 Intelligence (multi-trait analysis); LUSC trans rs1005277 0.579 rs2504140 chr10:38387579 T/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg18904891 chr8:8559673 CLDN23 0.38 5.89 0.31 9.52e-9 Mood instability; LUSC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg24578937 chr1:2090814 PRKCZ 0.45 10.15 0.49 2.74e-21 Height; LUSC cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg00012203 chr2:219082015 ARPC2 -0.76 -13.09 -0.58 6.86e-32 Pyoderma gangrenosum in inflammatory bowel disease; LUSC trans rs2739330 0.828 rs4822451 chr22:24248166 T/G cg06437703 chr8:37914619 EIF4EBP1 -0.56 -8.72 -0.43 1.31e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg04944784 chr2:26401820 FAM59B -0.7 -9.79 -0.47 4.69e-20 Gut microbiome composition (summer); LUSC cis rs4680 1.000 rs4633 chr22:19950235 C/T cg22546130 chr22:19950026 COMT 0.26 5.75 0.3 2.02e-8 Blood metabolite levels; LUSC cis rs3008870 1.000 rs2009319 chr1:67481070 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.07 0.64 1.63e-39 Lymphocyte percentage of white cells; LUSC cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg15691649 chr6:25882328 NA -0.39 -6.32 -0.33 8.37e-10 Blood metabolite levels; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg06873352 chr17:61820015 STRADA 0.7 12.71 0.57 1.91e-30 Prudent dietary pattern; LUSC cis rs6546537 0.915 rs4852866 chr2:69829916 T/C cg10773587 chr2:69614142 GFPT1 -0.47 -7.38 -0.37 1.23e-12 Serum thyroid-stimulating hormone levels; LUSC cis rs6598955 0.950 rs6700455 chr1:26545864 T/C cg04990556 chr1:26633338 UBXN11 0.83 13.05 0.58 9.57e-32 Obesity-related traits; LUSC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg04362960 chr10:104952993 NT5C2 0.61 8.9 0.44 3.71e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs71435601 0.657 rs1878512 chr2:21420358 C/A cg20757404 chr19:378427 NA -0.41 -6.32 -0.33 8.46e-10 Cholesterol, total; LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.4 0.62 6.35e-37 Platelet count; LUSC cis rs4631830 0.720 rs113082846 chr10:51502802 G/C cg16070123 chr10:51489643 NA -0.57 -9.49 -0.46 4.65e-19 Prostate-specific antigen levels; LUSC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg14552801 chr7:65878734 NA -0.37 -5.71 -0.3 2.46e-8 Aortic root size; LUSC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs2486288 0.656 rs11637920 chr15:45550905 T/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.02e-14 Glomerular filtration rate; LUSC cis rs7200543 1.000 rs14347 chr16:15133889 T/G cg03427771 chr16:15082598 PDXDC1 -0.41 -5.71 -0.3 2.53e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg14784868 chr12:69753453 YEATS4 0.82 13.98 0.61 2.89e-35 Blood protein levels; LUSC cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.47 0.56 1.45e-29 Motion sickness; LUSC cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1728785 1.000 rs7205960 chr16:68565604 G/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.34 -0.42 1.95e-15 Total body bone mineral density; LUSC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg07700843 chr1:2391317 NA -0.44 -7.87 -0.4 5.12e-14 Schizophrenia; LUSC cis rs868036 1.000 rs1026733 chr15:68095122 G/A cg05925327 chr15:68127851 NA -0.32 -5.7 -0.3 2.67e-8 Restless legs syndrome; LUSC trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg21775007 chr8:11205619 TDH -0.45 -6.73 -0.35 7.3e-11 Neuroticism; LUSC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg05855489 chr10:104503620 C10orf26 0.6 9.6 0.47 1.97e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg06784218 chr1:46089804 CCDC17 0.53 10.22 0.49 1.67e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2710642 0.962 rs6545972 chr2:63084682 G/A cg17519650 chr2:63277830 OTX1 0.49 6.92 0.35 2.36e-11 LDL cholesterol levels;LDL cholesterol; LUSC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.74 13.64 0.6 5.77e-34 Intelligence (multi-trait analysis); LUSC trans rs10256972 0.706 rs4285396 chr7:1123738 A/G cg13565492 chr6:43139072 SRF -0.43 -6.37 -0.33 6.34e-10 Longevity;Endometriosis; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg14004847 chr7:1930337 MAD1L1 -0.54 -8.45 -0.42 8.86e-16 Bipolar disorder and schizophrenia; LUSC cis rs10782582 0.609 rs1796827 chr1:76391536 A/T cg03433033 chr1:76189801 ACADM -0.39 -5.77 -0.3 1.85e-8 Daytime sleep phenotypes; LUSC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg05425664 chr17:57184151 TRIM37 0.54 7.95 0.4 2.9e-14 Intelligence (multi-trait analysis); LUSC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg24399712 chr22:39784796 NA 0.65 12.15 0.55 2.31e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg18477163 chr1:228402036 OBSCN 0.62 12.18 0.55 1.73e-28 Diastolic blood pressure; LUSC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg18230493 chr5:56204884 C5orf35 -0.93 -13.83 -0.6 1.01e-34 Initial pursuit acceleration; LUSC cis rs4728302 0.583 rs12707091 chr7:133185749 A/G cg10665199 chr7:133106180 EXOC4 0.55 7.76 0.39 1.03e-13 Intelligence;Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26880073 chr19:48018745 NAPA -0.44 -6.66 -0.34 1.11e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg06238570 chr21:40685208 BRWD1 0.6 9.88 0.48 2.35e-20 Cognitive function; LUSC cis rs4845459 0.933 rs11205044 chr1:152593437 T/C cg08895932 chr1:152778580 LCE1C -0.38 -6.53 -0.34 2.46e-10 Psoriasis; LUSC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg13390004 chr1:15929781 NA 0.42 7.0 0.36 1.43e-11 Systolic blood pressure; LUSC cis rs460214 0.528 rs4817954 chr21:40023857 C/T cg05519781 chr21:40033154 ERG -0.45 -6.01 -0.31 4.86e-9 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs2932538 0.883 rs6537740 chr1:113080084 T/G cg22162597 chr1:113214053 CAPZA1 0.72 10.14 0.49 2.99e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs67072384 1.000 rs61489692 chr11:72445314 T/C cg04827223 chr11:72435913 ARAP1 -0.82 -7.76 -0.39 1.04e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.88e-19 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg25036284 chr2:26402008 FAM59B -0.74 -10.56 -0.5 1.13e-22 Gut microbiome composition (summer); LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC cis rs193541 0.632 rs7729834 chr5:122122159 A/G cg19077854 chr5:122220652 SNX24 0.38 7.84 0.39 5.98e-14 Glucose homeostasis traits; LUSC cis rs62103177 0.525 rs4799117 chr18:77756604 G/A cg02751453 chr18:77725136 HSBP1L1 0.44 5.99 0.31 5.48e-9 Opioid sensitivity; LUSC cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs3764021 0.743 rs7973535 chr12:9880397 T/A cg20894963 chr12:9885564 CLECL1 0.33 6.76 0.35 5.99e-11 Type 1 diabetes; LUSC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg25036284 chr2:26402008 FAM59B -0.7 -9.79 -0.47 4.68e-20 Gut microbiome composition (summer); LUSC cis rs3845702 0.736 rs2678936 chr2:180872179 G/C cg01881094 chr2:180872142 CWC22 1.04 12.26 0.56 8.79e-29 Schizophrenia; LUSC cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg06064525 chr11:970664 AP2A2 -0.36 -7.11 -0.36 6.97e-12 Alzheimer's disease (late onset); LUSC cis rs2760061 0.583 rs697763 chr1:228192622 G/C cg02753203 chr1:228287806 NA 0.98 19.14 0.72 1.17e-55 Diastolic blood pressure; LUSC cis rs9393777 0.720 rs34864993 chr6:26970895 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.48 -5.87 -0.31 1.04e-8 Intelligence (multi-trait analysis); LUSC cis rs8010715 0.636 rs2277482 chr14:24587795 C/T cg23112188 chr14:24563095 PCK2 -0.32 -5.86 -0.31 1.14e-8 IgG glycosylation; LUSC cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.53 0.38 4.76e-13 Colorectal cancer; LUSC cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg03517284 chr6:25882590 NA -0.52 -9.59 -0.46 2.05e-19 Blood metabolite levels; LUSC cis rs1577917 0.761 rs117452258 chr6:86554211 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.54 -0.34 2.32e-10 Response to antipsychotic treatment; LUSC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg12365402 chr11:9010492 NRIP3 -0.51 -9.81 -0.47 4.04e-20 Hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10765857 chr11:6948101 ZNF215 0.44 6.82 0.35 4.23e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11190604 1.000 rs2489047 chr10:102347028 A/G cg07080220 chr10:102295463 HIF1AN 0.67 9.14 0.45 6.38e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs250677 0.687 rs250678 chr5:148434830 C/T cg18129178 chr5:148520854 ABLIM3 -0.66 -9.97 -0.48 1.13e-20 Breast cancer; LUSC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 11.9 0.55 1.91e-27 Hip circumference adjusted for BMI; LUSC cis rs11997175 0.626 rs6468189 chr8:33648189 C/A ch.8.33884649F chr8:33765107 NA 0.47 7.56 0.38 3.92e-13 Body mass index; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg00307073 chr7:116502428 CAPZA2 0.45 6.29 0.33 9.78e-10 Mosquito bite size; LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg14092988 chr3:52407081 DNAH1 0.33 6.32 0.33 8.52e-10 Bipolar disorder; LUSC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg04871131 chr7:94954202 PON1 -0.4 -6.2 -0.32 1.67e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs4343996 0.536 rs10228046 chr7:3414735 G/A cg21248987 chr7:3385318 SDK1 0.35 6.0 0.31 5.19e-9 Motion sickness; LUSC cis rs11209002 0.571 rs7531772 chr1:67555516 T/C cg02640540 chr1:67518911 SLC35D1 0.65 9.21 0.45 3.77e-18 Crohn's disease; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 6.93 0.35 2.21e-11 Platelet count; LUSC cis rs9457247 0.967 rs86755 chr6:167403108 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC trans rs3806843 1.000 rs7701755 chr5:140182101 G/T cg25815440 chr2:42134162 NA -0.26 -6.02 -0.31 4.51e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg19812747 chr11:111475976 SIK2 -0.52 -7.62 -0.39 2.57e-13 Primary sclerosing cholangitis; LUSC trans rs1493916 1.000 rs9964702 chr18:31390427 A/C cg27147174 chr7:100797783 AP1S1 -0.65 -10.41 -0.49 3.75e-22 Life satisfaction; LUSC cis rs2857891 0.817 rs2857899 chr11:6981668 A/C cg04053776 chr11:6947353 ZNF215 0.41 5.7 0.3 2.7e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2386661 0.712 rs11259544 chr10:5646708 T/C cg17085576 chr10:5658249 NA -0.44 -6.54 -0.34 2.34e-10 Breast cancer; LUSC trans rs2197308 0.765 rs10880643 chr12:37926452 C/T cg06521331 chr12:34319734 NA 0.4 6.32 0.33 8.45e-10 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -16.22 -0.66 4.98e-44 Gut microbiome composition (summer); LUSC cis rs4073416 0.568 rs8012834 chr14:65966555 C/T cg03016385 chr14:66212404 NA -0.4 -6.14 -0.32 2.36e-9 N-glycan levels; LUSC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC trans rs7939886 0.920 rs12226441 chr11:55867822 G/A cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -10.77 -0.51 2e-23 Chronic sinus infection; LUSC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1003719 0.699 rs1015549 chr21:38448880 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.42 0.53 9.82e-26 Eye color traits; LUSC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg14895029 chr7:2775587 GNA12 -0.37 -5.93 -0.31 7.62e-9 Height; LUSC trans rs3942852 0.806 rs11039515 chr11:48119474 A/G cg15704280 chr7:45808275 SEPT13 0.54 6.65 0.34 1.2e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs2742417 0.603 rs13059502 chr3:45781380 A/G cg10512202 chr3:45649293 LIMD1 0.36 6.11 0.32 2.71e-9 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs2736345 0.788 rs13277113 chr8:11349186 G/A cg15556689 chr8:8085844 FLJ10661 0.45 5.97 0.31 6.22e-9 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs4664304 0.658 rs2667008 chr2:160865095 C/T cg03641300 chr2:160917029 PLA2R1 -0.37 -6.15 -0.32 2.23e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg00784671 chr22:46762841 CELSR1 -0.48 -6.65 -0.34 1.18e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg00277334 chr10:82204260 NA -0.93 -20.3 -0.74 3e-60 Post bronchodilator FEV1; LUSC cis rs250677 0.652 rs36042 chr5:148439782 G/T cg23229984 chr5:148520753 ABLIM3 0.4 5.69 0.3 2.74e-8 Breast cancer; LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.25 -0.32 1.22e-9 Developmental language disorder (linguistic errors); LUSC cis rs1371867 0.817 rs1788185 chr8:101335529 T/C cg06002616 chr8:101225028 SPAG1 -0.45 -7.33 -0.37 1.75e-12 Atrioventricular conduction; LUSC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg07936489 chr17:37558343 FBXL20 -0.73 -10.02 -0.48 8.06e-21 Glomerular filtration rate (creatinine); LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg03188948 chr7:1209495 NA 0.66 6.91 0.35 2.44e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7223966 1.000 rs6504182 chr17:61823672 T/C cg00945038 chr17:61921165 SMARCD2 0.39 6.05 0.31 3.94e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7385804 0.761 rs1734908 chr7:100313768 G/T cg20848291 chr7:100343083 ZAN 0.38 5.88 0.31 1.02e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs10992471 0.603 rs7850528 chr9:95208992 A/G cg14631576 chr9:95140430 CENPP -0.33 -6.21 -0.32 1.56e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4595586 0.545 rs9669705 chr12:39374459 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.08e-9 Morning vs. evening chronotype; LUSC cis rs2011503 0.882 rs72999030 chr19:19364240 A/T cg22782873 chr19:19639568 YJEFN3 -0.47 -5.7 -0.3 2.59e-8 Bipolar disorder; LUSC cis rs7568458 0.905 rs6739015 chr2:85755357 A/G cg17127132 chr2:85788382 GGCX 0.47 7.66 0.39 2.03e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs4332037 0.664 rs73046334 chr7:1887037 T/C cg10840412 chr1:235813424 GNG4 0.47 6.02 0.31 4.71e-9 Bipolar disorder; LUSC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg02079420 chr8:82753780 SNX16 0.38 5.7 0.3 2.68e-8 Diastolic blood pressure; LUSC cis rs4843185 0.667 rs4143865 chr16:85716612 T/A cg26571870 chr16:85723150 GINS2 -0.34 -5.95 -0.31 6.8e-9 Platelet distribution width; LUSC cis rs936229 0.813 rs7085 chr15:75095483 T/C cg10253484 chr15:75165896 SCAMP2 -0.53 -7.09 -0.36 8.14e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg22535103 chr8:58192502 C8orf71 -0.69 -7.28 -0.37 2.35e-12 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg13798780 chr7:105162888 PUS7 0.55 6.05 0.31 3.99e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9467773 0.620 rs2494694 chr6:26619328 A/T cg05738196 chr6:26577821 NA 0.79 15.24 0.64 3.59e-40 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg00684032 chr4:1343700 KIAA1530 -0.37 -6.45 -0.33 3.93e-10 Obesity-related traits; LUSC cis rs4654899 0.931 rs58762579 chr1:21257831 G/A cg01072550 chr1:21505969 NA -0.54 -7.99 -0.4 2.28e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6700896 0.500 rs57941031 chr1:66087742 G/T cg14976592 chr1:65886160 LEPROT;LEPR 0.54 6.31 0.33 8.83e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg04234412 chr22:24373322 LOC391322 -0.86 -13.97 -0.61 3.02e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.18 -0.55 1.69e-28 Alzheimer's disease; LUSC cis rs9311676 0.656 rs62258102 chr3:58378784 T/C cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs6964587 0.904 rs2023785 chr7:91547369 C/A cg22709100 chr7:91322751 NA -0.39 -5.76 -0.3 1.89e-8 Breast cancer; LUSC cis rs9443189 0.570 rs7770824 chr6:76408189 G/A cg01950844 chr6:76311363 SENP6 0.67 6.73 0.35 7.37e-11 Prostate cancer; LUSC cis rs950169 0.580 rs11630887 chr15:85193015 A/T cg17173187 chr15:85201210 NMB 0.49 9.43 0.46 7.37e-19 Schizophrenia; LUSC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg05555928 chr11:63887634 MACROD1 0.35 6.66 0.34 1.15e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs523522 0.962 rs9040 chr12:120900274 C/T cg12219531 chr12:120966889 COQ5 0.61 8.31 0.41 2.46e-15 High light scatter reticulocyte count; LUSC cis rs1401999 0.510 rs17817736 chr3:183720313 A/T cg01324343 chr3:183735012 ABCC5 -0.51 -10.11 -0.48 3.91e-21 Anterior chamber depth; LUSC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg00509249 chr6:109615579 CCDC162 -0.34 -6.03 -0.31 4.24e-9 Reticulocyte fraction of red cells; LUSC cis rs9303542 0.625 rs17703636 chr17:46566890 C/T cg09704116 chr17:46666958 LOC404266 0.34 5.9 0.31 9.08e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs11098499 0.955 rs35197422 chr4:120169314 T/G cg24375607 chr4:120327624 NA 0.74 11.16 0.52 8.3e-25 Corneal astigmatism; LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.62e-9 Monocyte count; LUSC trans rs9393777 0.778 rs35526527 chr6:27042287 C/A cg06606381 chr12:133084897 FBRSL1 -0.7 -7.46 -0.38 7.62e-13 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs1372520 0.684 rs2737030 chr4:90710099 C/T cg01966878 chr4:90757139 SNCA -0.42 -5.8 -0.3 1.58e-8 Neuroticism; LUSC cis rs1577917 0.958 rs2225754 chr6:86449698 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.17 -0.37 4.72e-12 Response to antipsychotic treatment; LUSC trans rs6736587 0.785 rs11673909 chr2:81932827 A/T cg14247332 chr9:132805979 FNBP1 0.44 6.17 0.32 2.02e-9 Orthostatic hypotension; LUSC cis rs983392 0.679 rs7128450 chr11:60031270 G/C cg20284999 chr11:59952153 MS4A6A 0.38 6.38 0.33 5.85e-10 Alzheimer's disease (late onset); LUSC cis rs8017423 0.607 rs12885664 chr14:90845697 T/C cg04374321 chr14:90722782 PSMC1 -0.41 -6.05 -0.31 3.87e-9 Mortality in heart failure; LUSC cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg05347473 chr6:146136440 FBXO30 -0.59 -10.57 -0.5 1.02e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs2637266 0.783 rs846642 chr10:78522318 A/G cg18941641 chr10:78392320 NA -0.38 -6.79 -0.35 5.19e-11 Pulmonary function; LUSC trans rs12643440 0.549 rs965572 chr4:17223625 G/A cg03061682 chr15:28352098 NA 0.37 6.09 0.32 3.18e-9 Metabolite levels (Pyroglutamine); LUSC trans rs10802346 0.545 rs12134404 chr1:246372144 A/G cg22732515 chr19:44031385 ETHE1 0.62 10.32 0.49 7.17e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.47 8.1 0.41 1.06e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg21782813 chr7:2030301 MAD1L1 0.38 6.2 0.32 1.63e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2625529 0.730 rs2929528 chr15:72269337 C/A cg16672083 chr15:72433130 SENP8 0.5 8.01 0.4 1.95e-14 Red blood cell count; LUSC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg05313129 chr8:58192883 C8orf71 -0.48 -6.42 -0.33 4.56e-10 Developmental language disorder (linguistic errors); LUSC cis rs1348850 0.574 rs13431105 chr2:178434674 A/G cg27490568 chr2:178487706 NA 0.45 6.32 0.33 8.46e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10651300 chr12:53661859 ESPL1 0.43 6.14 0.32 2.37e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7605827 0.897 rs10432400 chr2:15667324 T/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg23711669 chr6:146136114 FBXO30 0.82 14.71 0.63 3.97e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs5758511 0.680 rs5758687 chr22:42656588 A/T cg00645731 chr22:42541494 CYP2D7P1 0.54 9.55 0.46 2.88e-19 Birth weight; LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg23758822 chr17:41437982 NA 1.03 18.74 0.72 4.56e-54 Menopause (age at onset); LUSC cis rs6495367 1.000 rs13380104 chr15:79378821 C/T cg17916960 chr15:79447300 NA 0.35 6.75 0.35 6.68e-11 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs568617 1.000 rs656980 chr11:65656282 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.5 6.15 0.32 2.15e-9 Crohn's disease; LUSC cis rs4792901 0.759 rs75491854 chr17:41574650 T/C cg22562494 chr17:41607896 ETV4 -0.32 -6.02 -0.31 4.58e-9 Dupuytren's disease; LUSC trans rs11098499 0.954 rs9998585 chr4:120396802 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.69 0.34 9.29e-11 Corneal astigmatism; LUSC cis rs7106204 0.686 rs12790317 chr11:24254405 T/C ch.11.24196551F chr11:24239977 NA 0.76 7.14 0.36 5.79e-12 Response to Homoharringtonine (cytotoxicity); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03637614 chr7:129691233 ZC3HC1 -0.42 -6.18 -0.32 1.82e-9 Hepatitis; LUSC cis rs11098499 1.000 rs10029750 chr4:120172543 A/G cg09307838 chr4:120376055 NA 0.69 10.05 0.48 5.95e-21 Corneal astigmatism; LUSC cis rs7914558 0.621 rs7896290 chr10:104656015 G/A cg05855489 chr10:104503620 C10orf26 0.42 5.7 0.3 2.64e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg17264618 chr3:40429014 ENTPD3 -0.29 -6.34 -0.33 7.61e-10 Renal cell carcinoma; LUSC cis rs4820539 0.966 rs3788350 chr22:23468468 C/T cg14186256 chr22:23484241 RTDR1 0.92 16.67 0.67 7.73e-46 Bone mineral density; LUSC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.57 8.43 0.42 1.04e-15 Total body bone mineral density; LUSC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg21724239 chr8:58056113 NA 0.59 7.09 0.36 8.15e-12 Developmental language disorder (linguistic errors); LUSC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7100689 0.622 rs7082093 chr10:82134954 T/G cg00277334 chr10:82204260 NA -0.5 -7.26 -0.37 2.8e-12 Post bronchodilator FEV1; LUSC cis rs4919694 1.000 rs7100592 chr10:104769098 T/G cg23093090 chr10:104574429 C10orf26 -0.47 -5.76 -0.3 1.93e-8 Arsenic metabolism; LUSC cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg16586182 chr3:47516702 SCAP -0.51 -7.93 -0.4 3.34e-14 Colorectal cancer; LUSC cis rs5758511 0.680 rs17002902 chr22:42625509 C/G cg00645731 chr22:42541494 CYP2D7P1 0.58 10.21 0.49 1.8e-21 Birth weight; LUSC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg22823121 chr1:150693482 HORMAD1 0.6 9.13 0.45 6.6e-18 Tonsillectomy; LUSC cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg23583168 chr7:148888333 NA 0.9 17.11 0.68 1.37e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9650657 0.683 rs7836366 chr8:10585683 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.4 -0.33 5.14e-10 Neuroticism; LUSC cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg00339695 chr16:24857497 SLC5A11 0.39 6.73 0.35 7.55e-11 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg24531977 chr5:56204891 C5orf35 -1.06 -16.01 -0.66 3.25e-43 Initial pursuit acceleration; LUSC cis rs7258465 1.000 rs4808804 chr19:18585325 A/G cg01065977 chr19:18549689 ISYNA1 -0.25 -6.14 -0.32 2.37e-9 Breast cancer; LUSC cis rs1065852 0.526 rs9623490 chr22:42398266 G/C cg22189786 chr22:42395067 WBP2NL 0.43 5.75 0.3 1.97e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC trans rs3812049 0.826 rs17764730 chr5:127357526 A/G cg16011800 chr17:1958478 HIC1 -0.46 -6.06 -0.31 3.72e-9 Lymphocyte counts;Red cell distribution width; LUSC cis rs9733 0.680 rs3738484 chr1:150552330 G/T cg13175981 chr1:150552382 MCL1 0.53 7.4 0.38 1.09e-12 Tonsillectomy; LUSC cis rs7512552 0.839 rs11205357 chr1:150267798 T/C cg15654264 chr1:150340011 RPRD2 -0.64 -10.84 -0.51 1.19e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg01884057 chr2:25150051 NA 0.48 11.43 0.53 9.67e-26 Body mass index; LUSC cis rs2017854 1.000 rs2017854 chr17:65488021 C/G cg07622687 chr17:65503465 PITPNC1 -0.38 -6.53 -0.34 2.43e-10 Pulmonary function; LUSC cis rs7572644 0.709 rs7592580 chr2:28121190 C/T cg27432699 chr2:27873401 GPN1 0.52 6.43 0.33 4.31e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7572644 0.699 rs6547814 chr2:28102998 G/A cg27432699 chr2:27873401 GPN1 0.52 7.0 0.36 1.43e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs2050392 0.517 rs589980 chr10:30756385 T/A cg17737641 chr12:71834466 LGR5 0.39 5.98 0.31 5.79e-9 Inflammatory bowel disease; LUSC cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg24130564 chr14:104152367 KLC1 0.44 6.34 0.33 7.27e-10 Intelligence (multi-trait analysis); LUSC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg03684893 chr10:554711 DIP2C -0.37 -6.76 -0.35 6.28e-11 Psychosis in Alzheimer's disease; LUSC cis rs1322512 1.000 rs1744369 chr6:152946531 T/A cg27316956 chr6:152958899 SYNE1 -0.33 -5.65 -0.3 3.45e-8 Tonometry; LUSC cis rs8014204 0.816 rs11159107 chr14:75341266 C/A cg06637938 chr14:75390232 RPS6KL1 -0.55 -8.75 -0.43 1.07e-16 Caffeine consumption; LUSC cis rs76793172 1.000 rs10406609 chr19:46345208 T/G cg00442267 chr19:46317840 RSPH6A -0.5 -5.7 -0.3 2.66e-8 Eosinophil counts; LUSC cis rs116988415 0.584 rs17767466 chr14:65252095 G/T cg00114569 chr14:65239327 SPTB 0.67 7.18 0.37 4.46e-12 Daytime sleep phenotypes; LUSC cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg04455712 chr21:45112962 RRP1B 0.45 8.61 0.43 2.97e-16 Mean corpuscular volume; LUSC cis rs11077998 0.903 rs8064554 chr17:80501093 A/G cg10255544 chr17:80519551 FOXK2 0.41 6.69 0.34 9.4e-11 Reticulocyte fraction of red cells; LUSC trans rs769267 0.629 rs7245672 chr19:19699963 T/C cg01128736 chr6:4461158 NA 0.34 6.03 0.31 4.35e-9 Tonsillectomy; LUSC cis rs870825 0.616 rs7654208 chr4:185648877 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg11645453 chr3:52864694 ITIH4 -0.34 -8.0 -0.4 2.08e-14 Bipolar disorder; LUSC cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.15 -0.45 5.74e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2012796 1.000 rs8009171 chr14:81820060 G/A cg02996355 chr14:81879375 NA 0.5 7.24 0.37 3.08e-12 Night sleep phenotypes; LUSC cis rs12681287 0.577 rs13257414 chr8:87494138 C/T cg00550725 chr8:87521180 FAM82B 0.45 5.87 0.31 1.07e-8 Caudate activity during reward; LUSC trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg03929089 chr4:120376271 NA -0.6 -7.21 -0.37 3.79e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg12257692 chr3:49977190 RBM6 0.25 6.93 0.35 2.14e-11 Body mass index; LUSC cis rs7100689 0.784 rs10887838 chr10:82161380 G/A cg00277334 chr10:82204260 NA -0.53 -7.17 -0.37 4.8e-12 Post bronchodilator FEV1; LUSC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg27411982 chr8:10470053 RP1L1 0.39 6.05 0.31 3.84e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg07148914 chr20:33460835 GGT7 -0.54 -8.43 -0.42 1.04e-15 Height; LUSC cis rs6503863 1 rs6503863 chr17:56517034 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.46 7.06 0.36 9.59e-12 Intelligence (multi-trait analysis); LUSC cis rs2658782 0.901 rs7116173 chr11:93222311 C/T cg15737290 chr11:93063684 CCDC67 -0.63 -7.62 -0.38 2.71e-13 Pulmonary function decline; LUSC trans rs57046232 0.531 rs6054146 chr20:6335865 G/T cg21095983 chr6:86352623 SYNCRIP 0.47 7.08 0.36 8.33e-12 Colorectal cancer; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg07529534 chr8:41511314 ANK1 0.37 6.28 0.32 1.04e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7000551 0.725 rs7430 chr8:22398414 C/G cg12081754 chr8:22256438 SLC39A14 0.41 6.08 0.32 3.35e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs3942852 0.868 rs7122335 chr11:48106486 C/T cg20307385 chr11:47447363 PSMC3 0.53 6.37 0.33 6.09e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs7119 0.717 rs62009069 chr15:77817877 T/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.48 -0.33 3.3e-10 Type 2 diabetes; LUSC cis rs9527 0.662 rs743575 chr10:104594906 T/G cg04362960 chr10:104952993 NT5C2 0.65 9.39 0.46 9.96e-19 Arsenic metabolism; LUSC cis rs1127311 1.000 rs1127311 chr1:154556663 G/A cg17218026 chr1:154582156 ADAR 0.57 9.84 0.47 3.15e-20 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4561483 0.583 rs1019814 chr16:11940764 T/C cg08843971 chr16:11963173 GSPT1 0.38 5.79 0.3 1.62e-8 Testicular germ cell tumor; LUSC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg15485101 chr11:133734466 NA 0.43 7.72 0.39 1.32e-13 Childhood ear infection; LUSC cis rs11645898 0.748 rs72787042 chr16:72067522 A/G cg14768367 chr16:72042858 DHODH -0.75 -8.07 -0.4 1.32e-14 Blood protein levels; LUSC cis rs9611519 0.929 rs9611466 chr22:41426299 A/T cg03806693 chr22:41940476 POLR3H -0.51 -6.96 -0.36 1.86e-11 Neuroticism; LUSC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.14e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6574644 1.000 rs10873336 chr14:81779134 C/T cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs4285028 1.000 rs4285028 chr3:121660664 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.75 -10.13 -0.48 3.21e-21 Multiple sclerosis; LUSC cis rs7851660 0.594 rs28703314 chr9:100660145 A/T cg13688889 chr9:100608707 NA -0.54 -8.36 -0.42 1.76e-15 Strep throat; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10715425 chr1:6052497 NPHP4 0.43 6.17 0.32 1.92e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg07395648 chr5:131743802 NA 0.44 7.13 0.36 6.08e-12 Blood metabolite levels; LUSC cis rs10392 0.543 rs12626105 chr20:37534582 A/G cg27552599 chr20:37590471 DHX35 0.44 6.95 0.36 1.9e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs1971762 0.583 rs3844370 chr12:54086137 G/C cg23533419 chr12:54090519 NA -0.36 -5.95 -0.31 6.87e-9 Height; LUSC cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg09904177 chr6:26538194 HMGN4 0.67 12.17 0.55 1.87e-28 Intelligence (multi-trait analysis); LUSC cis rs1691799 0.899 rs1168306 chr12:66738900 A/G cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.45e-31 White blood cell count (basophil); LUSC trans rs9329221 0.905 rs28712068 chr8:10251145 G/C cg08975724 chr8:8085496 FLJ10661 -0.46 -6.59 -0.34 1.7e-10 Neuroticism; LUSC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg05729581 chr11:3078854 CARS -0.53 -7.9 -0.4 4.01e-14 Type 2 diabetes; LUSC cis rs7107174 0.892 rs11601866 chr11:78011153 G/A cg02023728 chr11:77925099 USP35 0.49 6.88 0.35 3.02e-11 Testicular germ cell tumor; LUSC cis rs7493 0.950 rs7802171 chr7:95030321 A/G cg17330251 chr7:94953956 PON1 -0.37 -5.85 -0.31 1.15e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7017697 0.642 rs3927029 chr8:19681933 G/A cg03894339 chr8:19674705 INTS10 -0.62 -8.63 -0.43 2.48e-16 Breast cancer; LUSC trans rs9944715 0.954 rs6507677 chr18:43762557 T/C cg01718231 chr17:29326311 RNF135 0.55 7.86 0.4 5.46e-14 Red cell distribution width;Mean corpuscular volume; LUSC cis rs12776158 0.901 rs12414706 chr10:71214729 G/A cg12610070 chr10:71211762 TSPAN15 -0.46 -6.04 -0.31 4.07e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7193541 0.694 rs3896277 chr16:74480694 A/T cg01733217 chr16:74700730 RFWD3 0.78 13.68 0.6 3.81e-34 Multiple myeloma; LUSC cis rs6084875 0.785 rs2050370 chr20:4719781 G/T cg07258627 chr20:4721683 PRNT -0.34 -6.12 -0.32 2.69e-9 Systemic lupus erythematosus; LUSC cis rs7937682 1.000 rs7128353 chr11:111538875 A/G cg09085632 chr11:111637200 PPP2R1B -1.08 -17.52 -0.69 3.33e-49 Primary sclerosing cholangitis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01580613 chr20:10015660 ANKRD5 -0.43 -6.53 -0.34 2.44e-10 Electrocardiographic conduction measures; LUSC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg15448220 chr1:150897856 SETDB1 0.41 5.9 0.31 8.97e-9 Melanoma; LUSC cis rs2637266 0.935 rs2583049 chr10:78403962 T/C cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg25319279 chr11:5960081 NA -0.44 -6.33 -0.33 7.95e-10 DNA methylation (variation); LUSC cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.99e-12 Motion sickness; LUSC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs3126085 1.000 rs3126095 chr1:152309683 G/A cg26876637 chr1:152193138 HRNR -0.44 -5.67 -0.3 3.13e-8 Atopic dermatitis; LUSC cis rs6120849 0.754 rs3746435 chr20:33587198 G/C cg24642439 chr20:33292090 TP53INP2 0.63 6.91 0.35 2.47e-11 Protein C levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24596729 chr1:165345813 NA -0.4 -7.31 -0.37 1.96e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg12311346 chr5:56204834 C5orf35 -0.67 -9.63 -0.47 1.54e-19 Coronary artery disease; LUSC trans rs72674100 1.000 rs78448853 chr4:97966420 G/A cg16405019 chr1:18959625 PAX7 -0.61 -6.0 -0.31 5.27e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs11864453 0.680 rs8047377 chr16:72148339 T/C cg01557791 chr16:72042693 DHODH -0.48 -7.04 -0.36 1.09e-11 Fibrinogen levels; LUSC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg11632617 chr15:75315747 PPCDC -0.52 -6.73 -0.35 7.58e-11 Blood trace element (Zn levels); LUSC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg14552801 chr7:65878734 NA -0.37 -5.72 -0.3 2.4e-8 Aortic root size; LUSC cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg13010199 chr12:38710504 ALG10B 0.61 9.57 0.46 2.39e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs16867335 1.000 rs34842451 chr2:181480525 C/T cg23363182 chr2:181467187 NA 0.48 6.38 0.33 5.87e-10 Survival in rectal cancer; LUSC cis rs7582180 0.700 rs11685401 chr2:100976685 A/G cg08017756 chr2:100939284 LONRF2 -0.43 -8.05 -0.4 1.48e-14 Intelligence (multi-trait analysis); LUSC trans rs3781871 0.891 rs12574049 chr11:107858027 C/G cg09222123 chr1:89356608 GTF2B -0.61 -5.99 -0.31 5.47e-9 Scarlet fever; LUSC cis rs9467711 0.659 rs35555795 chr6:26509382 C/T cg09904177 chr6:26538194 HMGN4 -0.79 -6.17 -0.32 1.95e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs10782582 0.593 rs2147039 chr1:76143166 C/T cg03433033 chr1:76189801 ACADM -0.45 -6.88 -0.35 3.04e-11 Daytime sleep phenotypes; LUSC cis rs10911232 0.507 rs6660111 chr1:183014289 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 11.03 0.52 2.43e-24 Hypertriglyceridemia; LUSC cis rs654950 0.875 rs55865698 chr1:41986758 C/T cg06885757 chr1:42089581 HIVEP3 -0.38 -7.52 -0.38 5.15e-13 Airway imaging phenotypes; LUSC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg03388025 chr16:89894329 SPIRE2 0.31 6.45 0.33 3.92e-10 Vitiligo; LUSC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg18904891 chr8:8559673 CLDN23 0.41 6.36 0.33 6.47e-10 Mood instability; LUSC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg23985595 chr17:80112537 CCDC57 0.31 5.91 0.31 8.51e-9 Life satisfaction; LUSC cis rs11864453 1.000 rs7201491 chr16:72034312 G/A cg01557791 chr16:72042693 DHODH -0.54 -7.92 -0.4 3.67e-14 Fibrinogen levels; LUSC cis rs72781680 0.898 rs72786298 chr2:24083011 C/T cg08917208 chr2:24149416 ATAD2B 0.97 10.06 0.48 5.54e-21 Lymphocyte counts; LUSC cis rs7291412 0.929 rs7289457 chr22:46456603 C/T cg09693106 chr22:46449821 C22orf26;LOC150381 0.48 7.97 0.4 2.47e-14 Dupuytren's disease;Subjective well-being; LUSC cis rs7829975 0.514 rs2920991 chr8:8259117 T/A cg06636001 chr8:8085503 FLJ10661 0.68 11.39 0.53 1.28e-25 Mood instability; LUSC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg05855489 chr10:104503620 C10orf26 -0.7 -10.37 -0.49 5.1e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11971779 0.793 rs11543827 chr7:139032693 G/A cg07862535 chr7:139043722 LUC7L2 0.58 6.96 0.36 1.8e-11 Diisocyanate-induced asthma; LUSC cis rs317689 0.718 rs315130 chr12:69761444 T/C cg11871910 chr12:69753446 YEATS4 0.63 8.44 0.42 9.86e-16 Response to diuretic therapy; LUSC cis rs9914988 0.943 rs11652272 chr17:27167973 C/G cg07195577 chr17:27052828 TLCD1 0.46 5.81 0.3 1.47e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9560113 0.573 rs9560132 chr13:112237456 C/T cg10483660 chr13:112241077 NA 0.39 7.09 0.36 7.92e-12 Menarche (age at onset); LUSC trans rs12570744 0.688 rs11254449 chr10:6796502 G/T cg11642127 chr8:142593671 NA 0.3 5.98 0.31 5.78e-9 Response to anti-TNF therapy in rheumatoid arthritis; LUSC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.67 -0.39 1.9e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg02753203 chr1:228287806 NA -0.65 -11.3 -0.53 2.7e-25 Diastolic blood pressure; LUSC cis rs4803468 0.967 rs3826713 chr19:41892269 C/T cg09537434 chr19:41945824 ATP5SL -0.88 -15.73 -0.65 3.98e-42 Height; LUSC cis rs3845702 0.668 rs12693215 chr2:180826007 A/C cg01881094 chr2:180872142 CWC22 -1.04 -12.47 -0.56 1.5e-29 Schizophrenia; LUSC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg00074818 chr8:8560427 CLDN23 0.57 9.8 0.47 4.19e-20 Obesity-related traits; LUSC cis rs13401104 0.633 rs72620804 chr2:237111501 T/A cg19324714 chr2:237145437 ASB18 0.43 5.79 0.3 1.6e-8 Educational attainment; LUSC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6060717 0.610 rs2794383 chr20:34615152 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -6.37 -0.33 6.14e-10 Hip circumference adjusted for BMI; LUSC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC cis rs7809950 1.000 rs2237672 chr7:107131563 A/C cg23024343 chr7:107201750 COG5 -0.55 -8.87 -0.44 4.63e-17 Coronary artery disease; LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg00684032 chr4:1343700 KIAA1530 0.33 6.04 0.31 4.1e-9 Obesity-related traits; LUSC cis rs6120849 0.754 rs13433216 chr20:33616301 T/C cg24642439 chr20:33292090 TP53INP2 0.61 6.74 0.35 6.84e-11 Protein C levels; LUSC trans rs3733585 0.781 rs4292328 chr4:9970962 C/T cg26043149 chr18:55253948 FECH -0.46 -6.93 -0.35 2.22e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg00431813 chr7:1051703 C7orf50 -0.36 -5.65 -0.3 3.47e-8 Longevity;Endometriosis; LUSC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg00745463 chr17:30367425 LRRC37B -0.71 -8.74 -0.43 1.14e-16 Hip circumference adjusted for BMI; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg22599036 chr21:43934540 SLC37A1 0.56 7.35 0.37 1.56e-12 Cognitive function;Information processing speed; LUSC cis rs6456156 0.586 rs9457266 chr6:167482555 T/C cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs7267979 0.780 rs6050679 chr20:25537827 A/T cg14121845 chr20:25566513 NINL 0.31 5.71 0.3 2.55e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7084921 0.640 rs12773244 chr10:101865344 G/A cg02250046 chr10:101825185 CPN1 -0.33 -6.11 -0.32 2.82e-9 Bone mineral density; LUSC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg03433033 chr1:76189801 ACADM 0.82 14.21 0.61 3.48e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg24829409 chr8:58192753 C8orf71 -0.47 -5.71 -0.3 2.49e-8 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg06740227 chr12:86229804 RASSF9 -0.36 -5.7 -0.3 2.61e-8 Major depressive disorder; LUSC cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg20283391 chr11:68216788 NA -0.57 -8.1 -0.41 1.03e-14 Total body bone mineral density; LUSC cis rs55665837 0.961 rs11023226 chr11:14458817 C/T cg05501817 chr11:14380813 RRAS2 -0.41 -6.51 -0.34 2.72e-10 Vitamin D levels; LUSC cis rs7075426 1.000 rs10887609 chr10:88206702 C/T cg07322936 chr10:88137208 NA -0.48 -7.5 -0.38 5.86e-13 Migraine without aura; LUSC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.42 0.33 4.71e-10 Menopause (age at onset); LUSC cis rs2760061 0.603 rs697761 chr1:228192397 G/A cg04850211 chr1:228464232 OBSCN -0.37 -6.2 -0.32 1.62e-9 Diastolic blood pressure; LUSC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.61 9.25 0.45 2.72e-18 Height; LUSC cis rs7712401 0.791 rs9327279 chr5:122122160 T/G cg19077854 chr5:122220652 SNX24 0.35 7.76 0.39 1.02e-13 Mean platelet volume; LUSC cis rs7095944 0.614 rs12570348 chr10:126438963 A/C cg08799069 chr10:126477246 METTL10 0.43 6.64 0.34 1.24e-10 Asthma; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg10360139 chr7:1886902 MAD1L1 -0.43 -6.46 -0.33 3.79e-10 Bipolar disorder and schizophrenia; LUSC trans rs1015291 0.708 rs10743340 chr12:19994777 G/A cg01501474 chr7:55323552 NA 0.46 5.96 0.31 6.32e-9 Diastolic blood pressure; LUSC cis rs757110 0.803 rs7928810 chr11:17372443 G/T cg15432903 chr11:17409602 KCNJ11 0.58 10.6 0.5 7.8e-23 Type 2 diabetes; LUSC cis rs13315871 1.000 rs36097398 chr3:58367330 G/A cg20936604 chr3:58311152 NA -0.63 -5.85 -0.31 1.15e-8 Cholesterol, total; LUSC cis rs9916302 0.706 rs7503081 chr17:37482673 A/G cg07936489 chr17:37558343 FBXL20 0.83 10.4 0.49 3.89e-22 Glomerular filtration rate (creatinine); LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.58 0.54 2.74e-26 Alzheimer's disease; LUSC cis rs7568458 0.709 rs2043675 chr2:85769975 C/T cg23752985 chr2:85803571 VAMP8 -0.33 -6.5 -0.34 2.89e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg05347473 chr6:146136440 FBXO30 0.56 9.49 0.46 4.63e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.68 0.34 9.71e-11 Menopause (age at onset); LUSC cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg11266682 chr4:10021025 SLC2A9 -0.49 -8.94 -0.44 2.6e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs568617 0.953 rs658524 chr11:65647260 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.51 -6.14 -0.32 2.39e-9 Crohn's disease; LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg05623727 chr3:50126028 RBM5 -0.34 -6.32 -0.33 8.55e-10 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg08499158 chr17:42289980 UBTF -0.54 -9.05 -0.44 1.23e-17 Total body bone mineral density; LUSC cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg23649088 chr2:200775458 C2orf69 -0.49 -6.71 -0.34 8.12e-11 Schizophrenia; LUSC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg16339924 chr4:17578868 LAP3 0.63 9.88 0.48 2.3e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9354308 0.840 rs17508021 chr6:66569748 G/A cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg07936489 chr17:37558343 FBXL20 -0.72 -10.11 -0.48 3.99e-21 Glomerular filtration rate (creatinine); LUSC cis rs6942756 1.000 rs2718084 chr7:128897342 T/C cg02491457 chr7:128862824 NA 0.56 8.07 0.4 1.29e-14 White matter hyperintensity burden; LUSC cis rs11690935 0.959 rs10174525 chr2:172635697 T/C cg13550731 chr2:172543902 DYNC1I2 -0.89 -15.02 -0.63 2.57e-39 Schizophrenia; LUSC cis rs4409675 0.576 rs10751724 chr1:28215631 C/T cg23691781 chr1:28212827 C1orf38 0.31 7.44 0.38 8.79e-13 Corneal astigmatism; LUSC cis rs1983891 0.955 rs2025645 chr6:41519654 A/G cg20194872 chr6:41519635 FOXP4 0.33 5.91 0.31 8.35e-9 Prostate cancer; LUSC cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg11266682 chr4:10021025 SLC2A9 0.58 10.63 0.5 6.41e-23 Bone mineral density; LUSC cis rs6681460 1.000 rs6681460 chr1:67123057 C/T cg02459107 chr1:67143332 SGIP1 -0.48 -9.0 -0.44 1.74e-17 Presence of antiphospholipid antibodies; LUSC cis rs10752881 0.602 rs9425569 chr1:182942202 C/T ch.1.3577855R chr1:183094577 LAMC1 0.67 9.56 0.46 2.6e-19 Colorectal cancer; LUSC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg14413466 chr17:79170920 AZI1 -0.38 -7.66 -0.39 2e-13 Frontotemporal dementia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22494142 chr15:40401263 BMF 0.51 7.1 0.36 7.55e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4595586 0.545 rs12826080 chr12:39387772 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC trans rs12317459 0.591 rs11115435 chr12:83200223 C/T cg10237817 chr1:154519846 TDRD10 0.31 6.22 0.32 1.46e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.51 -6.95 -0.36 1.95e-11 Tuberculosis; LUSC cis rs5758659 1.000 rs5751255 chr22:42648408 C/T cg04733989 chr22:42467013 NAGA 0.4 6.44 0.33 4.04e-10 Cognitive function; LUSC cis rs9463078 0.605 rs4711799 chr6:44765780 A/T cg25276700 chr6:44698697 NA 0.28 5.66 0.3 3.3e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg00701064 chr4:6280414 WFS1 0.6 14.2 0.61 3.95e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs912057 0.671 rs1294425 chr6:6744292 G/A cg06612196 chr6:6737390 NA 0.56 11.11 0.52 1.32e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg16346588 chr10:242978 ZMYND11 -0.45 -6.16 -0.32 2.06e-9 Psychosis in Alzheimer's disease; LUSC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg02380750 chr20:61661411 NA 0.33 5.83 0.3 1.32e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs926938 0.527 rs360681 chr1:115496741 C/G cg01522456 chr1:115632236 TSPAN2 -0.42 -6.49 -0.33 3.03e-10 Autism; LUSC cis rs3761218 0.738 rs6084472 chr20:3771858 G/T cg02737268 chr20:3780182 CDC25B 0.4 8.15 0.41 7.24e-15 Bipolar disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23493127 chr6:144164392 LTV1 0.69 6.26 0.32 1.2e-9 Cognitive performance; LUSC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg21573476 chr21:45109991 RRP1B -0.38 -6.19 -0.32 1.76e-9 Mean corpuscular volume; LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg23758822 chr17:41437982 NA 1.05 20.13 0.74 1.43e-59 Menopause (age at onset); LUSC cis rs4808199 0.947 rs10401193 chr19:19591066 A/G cg03709012 chr19:19516395 GATAD2A 1.1 14.72 0.63 3.81e-38 Nonalcoholic fatty liver disease; LUSC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg02423579 chr7:2872169 GNA12 -0.46 -6.23 -0.32 1.44e-9 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21530174 chr5:151031796 NA 0.49 7.8 0.39 8.17e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg07507251 chr3:52567010 NT5DC2 0.34 6.67 0.34 1.06e-10 Bipolar disorder; LUSC cis rs4665630 0.522 rs4665626 chr2:23883120 A/T cg08063864 chr2:24346004 PFN4;LOC375190 -0.66 -5.99 -0.31 5.42e-9 Hypertension; LUSC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg09365446 chr1:150670422 GOLPH3L 0.47 7.18 0.37 4.62e-12 Melanoma; LUSC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg05347473 chr6:146136440 FBXO30 -0.56 -9.79 -0.47 4.57e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg11645453 chr3:52864694 ITIH4 0.35 8.14 0.41 7.76e-15 Bipolar disorder; LUSC cis rs559928 0.606 rs55970968 chr11:63961433 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 7.25 0.37 2.88e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21582582 chr3:182698605 DCUN1D1 0.44 7.64 0.39 2.27e-13 Intelligence (multi-trait analysis); LUSC cis rs9463078 0.932 rs1324538 chr6:45080144 T/A cg25276700 chr6:44698697 NA -0.29 -5.64 -0.3 3.58e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs12286929 0.609 rs7479259 chr11:115090715 T/A cg04055981 chr11:115044050 NA 0.36 6.51 0.34 2.8e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs72781680 0.898 rs17763224 chr2:24213776 T/C cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.29e-21 Lymphocyte counts; LUSC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg17143192 chr8:8559678 CLDN23 0.61 8.73 0.43 1.28e-16 Obesity-related traits; LUSC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg24733560 chr20:60626293 TAF4 0.43 8.03 0.4 1.71e-14 Body mass index; LUSC cis rs6464929 0.956 rs4727005 chr7:148704869 C/T cg23583168 chr7:148888333 NA 0.47 5.94 0.31 7.06e-9 Pediatric bone mineral content (hip); LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.7 -10.13 -0.48 3.24e-21 Systemic lupus erythematosus; LUSC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.68 6.91 0.35 2.49e-11 Initial pursuit acceleration; LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg00149659 chr3:10157352 C3orf10 1.01 14.42 0.62 5.3e-37 Alzheimer's disease; LUSC cis rs2073300 1.000 rs12625804 chr20:23441981 G/A cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.89e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9900062 0.546 rs2676289 chr17:62705738 A/G cg02598441 chr17:62777298 LOC146880 0.54 7.17 0.37 4.75e-12 QT interval; LUSC cis rs12220238 1.000 rs10824088 chr10:75921490 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.92 0.35 2.36e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.34 5.66 0.3 3.24e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg03351412 chr1:154909251 PMVK 0.47 7.07 0.36 9.29e-12 Prostate cancer; LUSC cis rs3126085 0.935 rs4845745 chr1:152185184 C/T cg26876637 chr1:152193138 HRNR 0.42 5.96 0.31 6.41e-9 Atopic dermatitis; LUSC cis rs7223966 1.000 rs6504173 chr17:61735056 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.18 0.37 4.56e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9325144 0.957 rs1995419 chr12:38950726 C/G cg26384229 chr12:38710491 ALG10B 0.43 5.72 0.3 2.38e-8 Morning vs. evening chronotype; LUSC cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg04362960 chr10:104952993 NT5C2 0.61 9.77 0.47 5.38e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3858526 0.834 rs10769395 chr11:5979620 G/A cg13902645 chr11:5959945 NA -0.62 -8.58 -0.42 3.63e-16 DNA methylation (variation); LUSC cis rs7772486 0.806 rs4243478 chr6:146284560 A/G cg23711669 chr6:146136114 FBXO30 -0.82 -14.82 -0.63 1.52e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9640161 0.636 rs3735171 chr7:150033882 A/G cg21361702 chr7:150065534 REPIN1 0.49 6.53 0.34 2.41e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7833986 0.501 rs2667981 chr8:56894303 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.7 11.2 0.52 6.05e-25 Height; LUSC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg17385448 chr1:15911702 AGMAT 0.38 6.34 0.33 7.53e-10 Systolic blood pressure; LUSC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg18876405 chr7:65276391 NA -0.7 -12.57 -0.57 6.28e-30 Aortic root size; LUSC cis rs11098499 0.954 rs56270433 chr4:120406030 C/T cg24375607 chr4:120327624 NA 0.79 11.91 0.55 1.72e-27 Corneal astigmatism; LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs2439831 0.702 rs3759791 chr15:44090798 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.87 0.35 3.08e-11 Lung cancer in ever smokers; LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg10802521 chr3:52805072 NEK4 -0.55 -8.67 -0.43 1.92e-16 Bipolar disorder; LUSC cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg12573674 chr2:1569213 NA -0.52 -5.67 -0.3 3.07e-8 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg20573242 chr4:122745356 CCNA2 0.43 6.53 0.34 2.45e-10 Type 2 diabetes; LUSC cis rs6733011 0.578 rs10181972 chr2:99497284 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.83 -0.3 1.33e-8 Bipolar disorder; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg25703541 chr22:24373054 LOC391322 -0.9 -14.58 -0.62 1.38e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11711311 0.747 rs2895415 chr3:113345565 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 5.76 0.3 1.95e-8 IgG glycosylation; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg18110333 chr6:292329 DUSP22 -0.55 -8.17 -0.41 6.66e-15 Menopause (age at onset); LUSC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg13206674 chr6:150067644 NUP43 -0.6 -9.77 -0.47 5.42e-20 Lung cancer; LUSC cis rs796364 0.616 rs7574313 chr2:200681040 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.98 0.31 5.78e-9 Schizophrenia; LUSC cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -9.29 -0.45 2.05e-18 Monocyte percentage of white cells; LUSC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg03351412 chr1:154909251 PMVK 0.53 8.35 0.42 1.9e-15 Prostate cancer; LUSC cis rs8040855 0.657 rs6496733 chr15:85673176 G/T cg04831495 chr15:85060580 GOLGA6L5 0.38 5.86 0.31 1.08e-8 Bulimia nervosa; LUSC cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg23583168 chr7:148888333 NA -0.88 -16.73 -0.68 4.63e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs113835537 0.529 rs17580784 chr11:66214859 T/A cg24851651 chr11:66362959 CCS 0.55 8.03 0.4 1.72e-14 Airway imaging phenotypes; LUSC cis rs7786808 0.525 rs10253961 chr7:158194858 G/A cg09998033 chr7:158218633 PTPRN2 0.45 7.14 0.36 5.82e-12 Obesity-related traits; LUSC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg09650180 chr20:62225654 GMEB2 -0.68 -9.73 -0.47 7.21e-20 Glioblastoma; LUSC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg23625390 chr15:77176239 SCAPER 0.39 5.79 0.3 1.64e-8 Blood metabolite levels; LUSC trans rs7556950 0.572 rs74507577 chr2:41931366 C/T cg13792581 chr20:43590115 TOMM34 0.76 6.47 0.33 3.43e-10 Major depression and alcohol dependence; LUSC cis rs4654899 0.758 rs17453044 chr1:21517361 A/G cg01072550 chr1:21505969 NA -0.55 -8.34 -0.42 2e-15 Superior frontal gyrus grey matter volume; LUSC cis rs10089 1.000 rs4836367 chr5:127482592 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.88 12.44 0.56 1.93e-29 Ileal carcinoids; LUSC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -7.58 -0.38 3.34e-13 Personality dimensions; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03887910 chr6:26156499 HIST1H1E 0.44 5.95 0.31 6.65e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg00339695 chr16:24857497 SLC5A11 0.61 9.65 0.47 1.37e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg23711669 chr6:146136114 FBXO30 0.9 17.22 0.69 5.31e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs999943 0.774 rs12205634 chr6:33611667 C/G cg14003231 chr6:33640908 ITPR3 0.78 15.13 0.64 9.67e-40 Obesity (extreme); LUSC cis rs10465746 0.967 rs1475263 chr1:84339497 A/T cg10977910 chr1:84465055 TTLL7 0.45 6.39 0.33 5.52e-10 Obesity-related traits; LUSC cis rs12220238 1.000 rs10824112 chr10:75969003 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.22 0.37 3.42e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg04267008 chr7:1944627 MAD1L1 -0.6 -9.34 -0.45 1.45e-18 Bipolar disorder and schizophrenia; LUSC cis rs6542838 0.703 rs7593332 chr2:99467991 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.14 -0.32 2.28e-9 Fear of minor pain; LUSC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg17711541 chr6:26124704 HIST1H2AC;HIST1H2BC -0.47 -6.73 -0.35 7.24e-11 Urate levels; LUSC cis rs3106136 0.546 rs2664881 chr4:95143484 A/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.46 -0.42 8.25e-16 Capecitabine sensitivity; LUSC cis rs752010 0.905 rs10890150 chr1:42095603 A/C cg06885757 chr1:42089581 HIVEP3 0.49 9.93 0.48 1.56e-20 Lupus nephritis in systemic lupus erythematosus; LUSC trans rs208520 1.000 rs12194996 chr6:66973366 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 12.12 0.55 2.85e-28 Exhaled nitric oxide output; LUSC cis rs921968 0.544 rs58827325 chr2:219415166 A/T cg02176678 chr2:219576539 TTLL4 0.74 14.68 0.63 5.59e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs41271951 0.512 rs16832976 chr1:151038135 T/C cg11822372 chr1:151115635 SEMA6C -0.76 -6.95 -0.36 1.98e-11 Blood protein levels; LUSC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg22532475 chr10:104410764 TRIM8 -0.29 -5.98 -0.31 5.8e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg04586622 chr2:25135609 ADCY3 0.42 8.88 0.44 4.22e-17 Body mass index; LUSC cis rs2455601 0.608 rs59025804 chr11:8870301 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -7.64 -0.39 2.3e-13 Schizophrenia; LUSC cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg01028140 chr2:1542097 TPO -0.44 -6.92 -0.35 2.39e-11 IgG glycosylation; LUSC cis rs9473147 0.543 rs4715019 chr6:47447041 T/A cg12968598 chr6:47444699 CD2AP 0.53 8.18 0.41 6.12e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg25204440 chr1:209979598 IRF6 0.53 7.08 0.36 8.6e-12 Cleft lip with or without cleft palate; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03657549 chr7:128116813 METTL2B -0.53 -7.06 -0.36 9.85e-12 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg05347473 chr6:146136440 FBXO30 -0.56 -9.61 -0.47 1.83e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs6969780 0.915 rs3807597 chr7:27189195 C/T cg26364809 chr7:27145159 NA 0.54 6.0 0.31 5.1e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs9486719 1.000 rs12212614 chr6:97036466 T/G cg06623918 chr6:96969491 KIAA0776 -0.84 -10.4 -0.49 3.86e-22 Migraine;Coronary artery disease; LUSC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg18240062 chr17:79603768 NPLOC4 0.58 10.05 0.48 6.14e-21 Eye color traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08399230 chr16:4665037 FAM100A -0.44 -6.34 -0.33 7.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg06784218 chr1:46089804 CCDC17 -0.36 -7.27 -0.37 2.53e-12 Red blood cell count;Reticulocyte count; LUSC cis rs12711979 0.509 rs10205540 chr2:3827839 A/G cg17052675 chr2:3827356 NA -0.84 -20.23 -0.74 5.51e-60 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs73416724 1.000 rs112336903 chr6:43338115 T/C cg26312998 chr6:43337775 ZNF318 0.57 6.62 0.34 1.4e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg06462663 chr19:18546047 ISYNA1 0.44 7.67 0.39 1.91e-13 Breast cancer; LUSC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg16405210 chr4:1374714 KIAA1530 -0.63 -10.13 -0.48 3.29e-21 Longevity; LUSC cis rs7666738 0.570 rs10032272 chr4:99095601 T/C cg05340658 chr4:99064831 C4orf37 0.57 9.27 0.45 2.32e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg18252515 chr7:66147081 NA -1.23 -13.21 -0.59 2.46e-32 Diabetic kidney disease; LUSC cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Vitiligo; LUSC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg02079420 chr8:82753780 SNX16 0.38 5.72 0.3 2.33e-8 Diastolic blood pressure; LUSC cis rs11997175 0.569 rs36034014 chr8:33814219 G/A ch.8.33884649F chr8:33765107 NA -0.41 -6.14 -0.32 2.4e-9 Body mass index; LUSC trans rs8073060 0.586 rs4796100 chr17:33997657 G/T cg19694781 chr19:47549865 TMEM160 1.12 18.03 0.7 3.2e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs3740713 1.000 rs75740864 chr11:18470689 C/G cg07915343 chr11:18477680 LDHAL6A -0.54 -6.74 -0.35 6.85e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs10927875 0.965 rs3961710 chr1:16313172 C/T cg22431228 chr1:16359049 CLCNKA 0.44 8.5 0.42 6.23e-16 Dilated cardiomyopathy; LUSC cis rs9650657 0.504 rs7813802 chr8:11033976 C/T cg27411982 chr8:10470053 RP1L1 0.4 5.91 0.31 8.34e-9 Neuroticism; LUSC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg06640241 chr16:89574553 SPG7 0.7 11.26 0.52 3.74e-25 Multiple myeloma (IgH translocation); LUSC trans rs3960554 0.529 rs6465049 chr7:75874489 A/G cg19862616 chr7:65841803 NCRNA00174 0.61 7.44 0.38 8.43e-13 Eotaxin levels; LUSC cis rs533581 0.866 rs562812 chr16:88970944 G/A cg16701003 chr16:89028210 CBFA2T3 0.33 5.95 0.31 6.81e-9 Social autistic-like traits; LUSC cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg11584989 chr19:19387371 SF4 0.68 8.17 0.41 6.43e-15 Bipolar disorder; LUSC trans rs6964492 0.576 rs17168006 chr7:134406000 A/G cg17334389 chr17:637070 FAM57A -0.26 -6.01 -0.31 4.95e-9 Tonsillectomy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15804432 chr15:64454965 PPIB -0.44 -5.95 -0.31 6.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs951366 0.576 rs11240561 chr1:205712957 T/G cg14893161 chr1:205819251 PM20D1 -0.48 -6.47 -0.33 3.54e-10 Menarche (age at onset); LUSC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg03233332 chr7:66118400 NA -0.4 -5.91 -0.31 8.4e-9 Aortic root size; LUSC cis rs9462027 0.628 rs2814991 chr6:34615443 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.97 -0.31 6.1e-9 Systemic lupus erythematosus; LUSC cis rs9527 0.640 rs7089061 chr10:104723015 C/A cg08330031 chr10:104623503 C10orf32 0.31 5.64 0.3 3.54e-8 Arsenic metabolism; LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg21724239 chr8:58056113 NA 0.69 8.82 0.43 6.42e-17 Developmental language disorder (linguistic errors); LUSC cis rs9457247 0.602 rs12209395 chr6:167463914 C/T cg25258033 chr6:167368657 RNASET2 0.4 6.09 0.32 3.05e-9 Crohn's disease; LUSC cis rs861020 1.000 rs630984 chr1:209982293 C/T cg05527609 chr1:210001259 C1orf107 0.9 11.59 0.54 2.39e-26 Orofacial clefts; LUSC cis rs4308124 0.708 rs10179596 chr2:111970380 G/A cg04571233 chr2:111982156 NA -0.52 -6.75 -0.35 6.59e-11 Vitiligo; LUSC cis rs7945718 0.875 rs9888179 chr11:12782601 G/T cg25843174 chr11:12811716 TEAD1 0.32 7.3 0.37 2.13e-12 Educational attainment (years of education); LUSC cis rs7511006 0.893 rs5771104 chr22:50651839 C/T cg07895657 chr22:50616420 PANX2 -0.35 -5.99 -0.31 5.52e-9 Obesity-related traits; LUSC cis rs2798269 0.604 rs9552438 chr13:22067809 A/C cg18095732 chr13:22033692 ZDHHC20 -0.48 -7.84 -0.39 6.24e-14 PR segment; LUSC cis rs7845219 0.544 rs34208552 chr8:95908067 C/G cg16049864 chr8:95962084 TP53INP1 -0.42 -6.98 -0.36 1.6e-11 Type 2 diabetes; LUSC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg20849893 chr7:64541193 NA -0.65 -5.7 -0.3 2.6e-8 Diabetic kidney disease; LUSC cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg04586622 chr2:25135609 ADCY3 0.36 7.47 0.38 6.97e-13 Body mass index in non-asthmatics; LUSC cis rs1577917 0.958 rs6900436 chr6:86506288 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.75 -0.35 6.59e-11 Response to antipsychotic treatment; LUSC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.38 -0.33 5.88e-10 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15986590 chr19:1862404 KLF16 -0.48 -6.01 -0.31 4.98e-9 Bipolar disorder and schizophrenia; LUSC cis rs9399135 0.967 rs1023179 chr6:135343829 T/A cg24558204 chr6:135376177 HBS1L 0.59 9.14 0.45 6.29e-18 Red blood cell count; LUSC cis rs4683142 0.518 rs4682801 chr3:46021218 G/T cg18004856 chr3:46029278 FYCO1 0.37 5.88 0.31 1e-8 Methadone dose in opioid dependence; LUSC cis rs9549367 0.789 rs9549361 chr13:113898329 C/T cg00898013 chr13:113819073 PROZ 0.51 7.51 0.38 5.44e-13 Platelet distribution width; LUSC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.54 -8.44 -0.42 9.89e-16 Schizophrenia; LUSC cis rs4964805 1.000 rs11111789 chr12:104191540 G/C cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC trans rs12579753 1.000 rs17749267 chr12:82178308 A/G cg07923666 chr12:49932857 KCNH3 0.51 6.32 0.33 8.49e-10 Resting heart rate; LUSC cis rs9790314 1.000 rs1993891 chr3:161047467 A/G cg03342759 chr3:160939853 NMD3 -0.49 -8.18 -0.41 5.82e-15 Morning vs. evening chronotype; LUSC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg03433033 chr1:76189801 ACADM -0.8 -10.86 -0.51 9.65e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4664308 0.935 rs877200 chr2:160903723 G/C cg03641300 chr2:160917029 PLA2R1 -0.65 -11.11 -0.52 1.35e-24 Idiopathic membranous nephropathy; LUSC cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.24 0.41 4.06e-15 Axial length; LUSC cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg03146154 chr1:46216737 IPP -0.53 -7.71 -0.39 1.43e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg17385448 chr1:15911702 AGMAT 0.35 5.88 0.31 1e-8 Systolic blood pressure; LUSC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg15110403 chr19:17392923 ANKLE1 -0.52 -7.17 -0.37 4.89e-12 Systemic lupus erythematosus; LUSC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg05872129 chr22:39784769 NA -0.6 -10.92 -0.51 6.22e-24 Intelligence (multi-trait analysis); LUSC cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg08807101 chr21:30365312 RNF160 0.7 11.13 0.52 1.09e-24 Selective IgA deficiency; LUSC cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.35 -5.67 -0.3 3.1e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs17818399 0.547 rs7607633 chr2:46759427 T/C cg21681030 chr2:46777652 RHOQ 0.45 6.34 0.33 7.3e-10 Height; LUSC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg01503450 chr10:980765 NA -0.38 -5.7 -0.3 2.68e-8 Eosinophil percentage of granulocytes; LUSC cis rs7927592 0.913 rs3758643 chr11:68367193 C/T cg20283391 chr11:68216788 NA -0.6 -8.37 -0.42 1.61e-15 Total body bone mineral density; LUSC cis rs67460515 0.500 rs1345156 chr3:160649272 G/T cg03342759 chr3:160939853 NMD3 0.45 5.97 0.31 5.99e-9 Parkinson's disease; LUSC trans rs35110281 0.782 rs2246602 chr21:45064296 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 12.02 0.55 6.46e-28 Mean corpuscular volume; LUSC cis rs11608355 0.508 rs12817730 chr12:109799330 G/A cg19025524 chr12:109796872 NA -0.47 -8.59 -0.43 3.47e-16 Neuroticism; LUSC cis rs8038465 0.550 rs11072431 chr15:73987642 T/A cg15420318 chr15:73925796 NPTN 0.51 8.37 0.42 1.63e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11630290 0.736 rs7177695 chr15:64140228 C/T cg12036633 chr15:63758958 NA -0.69 -7.19 -0.37 4.32e-12 Iris characteristics; LUSC cis rs7267979 0.966 rs2424715 chr20:25420077 A/G cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2268241 0.938 rs11088251 chr21:34770810 A/C cg14850771 chr21:34775459 IFNGR2 0.86 11.5 0.53 5e-26 Obesity-related traits; LUSC cis rs2692947 0.740 rs11695514 chr2:96548068 C/T cg23100626 chr2:96804247 ASTL 0.29 6.66 0.34 1.12e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.66 0.39 1.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9611519 0.929 rs2064560 chr22:41530040 A/G cg13813247 chr22:41461852 NA -0.37 -6.73 -0.35 7.5e-11 Neuroticism; LUSC cis rs11785400 1.000 rs3802232 chr8:143746701 A/G cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC trans rs11700980 0.551 rs56165045 chr21:30114027 G/A cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs35306767 0.669 rs2101051 chr10:1158791 G/T cg26597838 chr10:835615 NA 0.58 6.86 0.35 3.32e-11 Eosinophil percentage of granulocytes; LUSC cis rs10203711 0.933 rs10187441 chr2:239577654 C/G cg14580085 chr2:239553406 NA 0.42 7.11 0.36 7.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs367943 1.000 rs367943 chr5:112809728 C/T cg12552261 chr5:112820674 MCC 0.45 7.01 0.36 1.31e-11 Type 2 diabetes; LUSC cis rs757081 0.667 rs12577418 chr11:17101554 C/G cg15432903 chr11:17409602 KCNJ11 -0.4 -6.2 -0.32 1.69e-9 Systolic blood pressure; LUSC cis rs7267979 0.834 rs6115100 chr20:25225938 C/A cg08601574 chr20:25228251 PYGB 0.49 7.55 0.38 4.23e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9399135 0.967 rs6569990 chr6:135365818 C/T cg22676075 chr6:135203613 NA 0.47 7.27 0.37 2.62e-12 Red blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05131957 chr20:5986808 CRLS1 0.44 6.66 0.34 1.11e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs240764 0.555 rs4840150 chr6:101183774 T/C cg09795085 chr6:101329169 ASCC3 0.43 6.18 0.32 1.85e-9 Neuroticism; LUSC cis rs4478858 0.684 rs12121165 chr1:31725542 G/A cg00250761 chr1:31883323 NA -0.34 -8.21 -0.41 4.89e-15 Alcohol dependence; LUSC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg13854012 chr2:162103682 NA -0.45 -7.97 -0.4 2.53e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg05844789 chr1:228464394 OBSCN -0.3 -5.76 -0.3 1.89e-8 Diastolic blood pressure; LUSC cis rs5167 0.534 rs56803710 chr19:45481884 C/T cg13119609 chr19:45449297 APOC2 0.34 5.67 0.3 3.01e-8 Blood protein levels; LUSC cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -11.94 -0.55 1.26e-27 Mean corpuscular volume; LUSC cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg24692254 chr21:30365293 RNF160 0.69 10.86 0.51 9.97e-24 Pancreatic cancer; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.43 0.53 9.43e-26 Alzheimer's disease; LUSC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg05785598 chr3:49045655 WDR6 0.33 5.85 0.3 1.17e-8 Parkinson's disease; LUSC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11644478 chr21:40555479 PSMG1 -0.75 -13.11 -0.58 5.66e-32 Cognitive function; LUSC cis rs62400317 0.859 rs12153922 chr6:45256159 T/C cg18551225 chr6:44695536 NA -0.43 -7.11 -0.36 7.02e-12 Total body bone mineral density; LUSC cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.11e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg21280719 chr6:42927975 GNMT -0.29 -7.14 -0.36 5.94e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2274273 0.564 rs3783649 chr14:55834410 G/A cg04306507 chr14:55594613 LGALS3 0.49 9.78 0.47 4.81e-20 Protein biomarker; LUSC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg06453172 chr10:134556979 INPP5A -0.52 -6.33 -0.33 7.79e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs977987 0.778 rs62059846 chr16:75430809 T/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.77 -0.35 5.88e-11 Dupuytren's disease; LUSC cis rs8060686 0.641 rs8060893 chr16:68191608 A/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs62238980 0.614 rs79343805 chr22:32522040 A/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -5.98 -0.31 5.76e-9 Childhood ear infection; LUSC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.42 -0.38 9.8e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.71 0.39 1.41e-13 Parkinson's disease; LUSC trans rs561341 0.941 rs501773 chr17:30314435 T/G cg20587970 chr11:113659929 NA -1.12 -15.55 -0.65 2.16e-41 Hip circumference adjusted for BMI; LUSC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 7.79 0.39 8.8e-14 Schizophrenia; LUSC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg01448562 chr3:133502909 NA -0.59 -8.94 -0.44 2.63e-17 Iron status biomarkers; LUSC cis rs9341835 0.518 rs6924479 chr6:64173940 A/G cg03326410 chr6:64151739 NA -0.36 -5.91 -0.31 8.23e-9 Schizophrenia; LUSC cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.56 0.5 1.11e-22 Homoarginine levels; LUSC cis rs6598163 0.520 rs12813376 chr12:132302324 C/T cg08236123 chr12:132219811 SFRS8 -0.43 -6.65 -0.34 1.19e-10 Migraine; LUSC cis rs7607369 0.648 rs7559490 chr2:219656867 A/T cg02176678 chr2:219576539 TTLL4 -0.66 -12.89 -0.58 4.08e-31 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs8077889 0.703 rs231532 chr17:41945769 C/T cg26893861 chr17:41843967 DUSP3 -0.81 -10.69 -0.5 4.03e-23 Triglycerides; LUSC cis rs7716219 0.578 rs7718675 chr5:54973702 A/C cg24729983 chr5:54530114 CCNO 0.48 5.97 0.31 5.94e-9 Height; LUSC cis rs478304 0.651 rs4930313 chr11:65500428 C/T cg10604040 chr11:65559109 OVOL1 0.31 5.72 0.3 2.34e-8 Acne (severe); LUSC cis rs11168618 0.846 rs11168580 chr12:48850424 G/T cg24011408 chr12:48396354 COL2A1 0.37 5.87 0.31 1.03e-8 Adiponectin levels; LUSC cis rs6750047 0.585 rs336033 chr2:38263808 A/G cg07380506 chr2:38303506 CYP1B1 -0.44 -6.4 -0.33 5.17e-10 Cutaneous malignant melanoma;Melanoma; LUSC cis rs2290416 0.579 rs58573550 chr8:144681714 G/A cg26536354 chr8:144654954 C8orf73 0.67 7.31 0.37 2.05e-12 Attention deficit hyperactivity disorder; LUSC trans rs10158481 0.759 rs6681610 chr1:25488413 A/T cg27042278 chr14:91720527 GPR68 -0.33 -6.23 -0.32 1.38e-9 Urate levels in obese individuals; LUSC cis rs10908458 0.584 rs10908454 chr1:155066416 C/T cg23973274 chr1:155060172 NA -0.33 -6.71 -0.34 8.59e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs8092503 1.000 rs12606265 chr18:52492470 T/C cg12377874 chr18:52495404 RAB27B 0.34 6.12 0.32 2.68e-9 Childhood body mass index; LUSC cis rs72634258 0.945 rs397349 chr1:8074872 A/C cg00042356 chr1:8021962 PARK7 0.63 8.37 0.42 1.65e-15 Inflammatory bowel disease; LUSC cis rs8013055 0.846 rs10139744 chr14:105974696 G/A cg19700328 chr14:106028568 NA -0.39 -6.29 -0.33 9.71e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs644799 0.648 rs1255176 chr11:95471465 A/T cg03916912 chr11:95522834 CEP57;FAM76B 0.59 9.13 0.45 6.77e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs7786808 0.505 rs67537656 chr7:158192646 C/T cg02030672 chr11:45687055 CHST1 -0.42 -6.61 -0.34 1.51e-10 Obesity-related traits; LUSC cis rs9831754 0.906 rs2089934 chr3:78382448 T/C cg06138941 chr3:78371609 NA -0.68 -9.28 -0.45 2.24e-18 Calcium levels; LUSC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg23262073 chr20:60523788 NA -0.42 -6.04 -0.31 4.06e-9 Body mass index; LUSC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg12310025 chr6:25882481 NA -0.42 -7.47 -0.38 6.94e-13 Height; LUSC cis rs7095944 0.585 rs11245357 chr10:126452042 A/G cg08799069 chr10:126477246 METTL10 -0.42 -6.57 -0.34 1.94e-10 Asthma; LUSC cis rs701145 0.938 rs189588 chr3:153995855 T/G cg17054900 chr3:154042577 DHX36 0.84 8.49 0.42 6.84e-16 Coronary artery disease; LUSC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg02428538 chr16:24856791 SLC5A11 -0.51 -6.0 -0.31 5.09e-9 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg08470875 chr2:26401718 FAM59B -0.66 -8.76 -0.43 1.02e-16 Gut microbiome composition (summer); LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg07507251 chr3:52567010 NT5DC2 0.33 6.44 0.33 4.15e-10 Bipolar disorder; LUSC cis rs3784262 0.757 rs74655564 chr15:58325512 G/C cg12031962 chr15:58353849 ALDH1A2 -0.35 -6.33 -0.33 7.71e-10 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg03433033 chr1:76189801 ACADM 0.8 13.2 0.59 2.64e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6121246 0.567 rs6120937 chr20:30219721 C/T cg18721089 chr20:30220636 NA -0.39 -6.08 -0.32 3.28e-9 Mean corpuscular hemoglobin; LUSC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg21951975 chr1:209979733 IRF6 0.62 8.06 0.4 1.4e-14 Cleft lip with or without cleft palate; LUSC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg15664640 chr17:80829946 TBCD 0.51 8.96 0.44 2.26e-17 Breast cancer; LUSC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.99 -0.4 2.15e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs177542 1 rs177542 chr11:16922654 G/A cg05701403 chr11:16947551 PLEKHA7 0.44 8.2 0.41 5.12e-15 Diastolic blood pressure; LUSC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.53 0.62 2.03e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.86 0.47 2.7e-20 Height; LUSC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.11 -0.32 2.81e-9 Total body bone mineral density; LUSC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg00933542 chr6:150070202 PCMT1 0.32 6.79 0.35 5.15e-11 Lung cancer; LUSC cis rs1775715 0.737 rs2808078 chr10:32172552 C/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.09 0.32 3.14e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg04352962 chr1:209979756 IRF6 -0.41 -6.16 -0.32 2.04e-9 Orofacial clefts; LUSC cis rs2073300 1.000 rs6048834 chr20:23462213 C/T cg09953122 chr20:23471693 CST8 -0.76 -7.49 -0.38 6.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07807409 chr6:150184969 LRP11 -0.4 -5.95 -0.31 6.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2073300 0.609 rs6132615 chr20:23413200 T/C cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4631830 0.720 rs2843560 chr10:51512129 C/G cg20129853 chr10:51489980 NA 0.35 7.19 0.37 4.26e-12 Prostate-specific antigen levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15938289 chr10:70091743 HNRNPH3;PBLD -0.41 -6.24 -0.32 1.36e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6519955 0.765 rs7292527 chr22:46423125 G/T cg23691090 chr22:46449981 C22orf26;LOC150381 -0.38 -5.99 -0.31 5.3300000000000004e-09 Dupuytren's disease; LUSC trans rs7824557 0.602 rs11781375 chr8:11204532 A/G cg08975724 chr8:8085496 FLJ10661 0.43 6.09 0.32 3.06e-9 Retinal vascular caliber; LUSC cis rs751728 1.000 rs9380378 chr6:33765479 T/C cg25922239 chr6:33757077 LEMD2 0.54 8.04 0.4 1.6e-14 Crohn's disease; LUSC cis rs17253792 0.915 rs17832389 chr14:56185836 A/G cg01858014 chr14:56050164 KTN1 -0.82 -6.98 -0.36 1.6e-11 Putamen volume; LUSC cis rs877282 0.583 rs12356155 chr10:823940 C/T cg13775593 chr10:823151 NA 0.31 6.17 0.32 1.96e-9 Uric acid levels; LUSC cis rs3772130 0.923 rs4298081 chr3:121526037 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.21 0.49 1.78e-21 Cognitive performance; LUSC cis rs4664304 0.802 rs1511224 chr2:160750861 C/T cg23995753 chr2:160760732 LY75 -0.3 -5.77 -0.3 1.78e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs477692 1.000 rs473771 chr10:131408155 A/C cg05714579 chr10:131428358 MGMT 0.51 7.55 0.38 4.31e-13 Response to temozolomide; LUSC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg24209194 chr3:40518798 ZNF619 -0.41 -5.89 -0.31 9.26e-9 Renal cell carcinoma; LUSC cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg00012203 chr2:219082015 ARPC2 -0.77 -13.8 -0.6 1.41e-34 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10779751 1.000 rs2024627 chr1:11298790 T/C cg08854313 chr1:11322531 MTOR 0.87 15.22 0.64 4.09e-40 Body mass index; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg27094323 chr7:1216898 NA -0.32 -5.65 -0.3 3.52e-8 Longevity;Endometriosis; LUSC cis rs17125944 0.686 rs6572868 chr14:53325090 C/T cg00686598 chr14:53173677 PSMC6 -0.65 -5.82 -0.3 1.4e-8 Alzheimer's disease (late onset); LUSC cis rs1322512 1.000 rs1727052 chr6:152947175 T/C cg27316956 chr6:152958899 SYNE1 -0.33 -5.65 -0.3 3.45e-8 Tonometry; LUSC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.43 5.77 0.3 1.85e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs981844 0.712 rs1563461 chr4:154751913 C/T cg14289246 chr4:154710475 SFRP2 -0.46 -6.3 -0.33 9.19e-10 Response to statins (LDL cholesterol change); LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg22638593 chr5:131593259 PDLIM4 0.49 7.46 0.38 7.65e-13 Acylcarnitine levels; LUSC cis rs11098499 0.722 rs10025925 chr4:120271744 A/T cg09307838 chr4:120376055 NA 0.63 9.59 0.46 2.07e-19 Corneal astigmatism; LUSC cis rs7223966 1.000 rs11870797 chr17:61804622 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.09 0.32 3.17e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs56283067 0.887 rs62437968 chr6:44729495 G/A cg18551225 chr6:44695536 NA -0.49 -8.41 -0.42 1.17e-15 Total body bone mineral density; LUSC cis rs1965732 1.000 rs11696000 chr2:3709907 A/G cg25251562 chr2:3704773 ALLC -0.39 -6.91 -0.35 2.42e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg03461704 chr1:205818484 PM20D1 0.39 6.69 0.34 9.32e-11 Menarche (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00094036 chr12:72057474 THAP2;ZFC3H1 -0.49 -7.37 -0.37 1.36e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg10664184 chr19:17420304 DDA1 0.5 6.45 0.33 3.95e-10 Systemic lupus erythematosus; LUSC cis rs9815354 0.556 rs55953604 chr3:42004428 A/G cg03022575 chr3:42003672 ULK4 0.81 8.53 0.42 5.02e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs12524093 0.541 rs76710331 chr6:143060357 G/A cg22454011 chr18:13611439 C18orf1 0.68 5.98 0.31 5.76e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs4795419 1 rs4795419 chr17:38166003 G/A cg17467752 chr17:38218738 THRA 0.78 12.54 0.57 7.78e-30 Monocyte percentage of white cells; LUSC cis rs8060686 0.546 rs8047978 chr16:68143598 T/G cg26727032 chr16:67993705 SLC12A4 -0.41 -6.35 -0.33 7.03e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs951366 0.531 rs12047038 chr1:205718468 A/G cg07167872 chr1:205819463 PM20D1 -0.43 -5.91 -0.31 8.44e-9 Menarche (age at onset); LUSC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4664308 0.618 rs17830940 chr2:160891768 T/C cg03641300 chr2:160917029 PLA2R1 -0.47 -7.82 -0.39 6.75e-14 Idiopathic membranous nephropathy; LUSC cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.7 0.43 1.57e-16 Motion sickness; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05848811 chr11:47270335 ACP2;NR1H3 -0.5 -6.57 -0.34 1.88e-10 Hepatitis; LUSC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4851254 0.584 rs35774174 chr2:100655130 T/A cg22139774 chr2:100720529 AFF3 -0.44 -5.75 -0.3 2.02e-8 Intelligence (multi-trait analysis); LUSC cis rs7560272 0.538 rs4852977 chr2:73938295 C/T cg20560298 chr2:73613845 ALMS1 0.42 6.55 0.34 2.17e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg17366294 chr4:99064904 C4orf37 0.57 10.04 0.48 6.92e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs10486158 0.790 rs1014419 chr7:7406081 C/G cg01895333 chr3:109035405 DPPA2 0.37 6.01 0.31 4.98e-9 Bipolar disorder and schizophrenia; LUSC cis rs314370 0.521 rs314308 chr7:100420878 C/T cg10426581 chr7:100472382 SRRT 0.54 8.33 0.41 2.09e-15 Resting heart rate; LUSC cis rs4478858 0.684 rs3766289 chr1:31760128 G/A cg00250761 chr1:31883323 NA -0.33 -7.95 -0.4 2.9e-14 Alcohol dependence; LUSC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg05373962 chr22:49881684 NA -0.44 -10.52 -0.5 1.55e-22 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg09509183 chr1:209979624 IRF6 0.42 5.7 0.3 2.69e-8 Cleft lip with or without cleft palate; LUSC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.1 0.48 4.18e-21 Bipolar disorder; LUSC trans rs3858145 0.588 rs61854833 chr10:70037327 C/G cg04882175 chr6:131122610 NA -0.65 -8.67 -0.43 1.89e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC trans rs62103177 0.564 rs3930043 chr18:77723832 G/A cg05926928 chr17:57297772 GDPD1 1.0 11.17 0.52 7.84e-25 Opioid sensitivity; LUSC trans rs35110281 0.837 rs2838341 chr21:45076443 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.96 0.48 1.25e-20 Mean corpuscular volume; LUSC cis rs9660992 0.674 rs56198325 chr1:205265450 G/A cg00857998 chr1:205179979 DSTYK 0.59 9.04 0.44 1.34e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg20476274 chr7:133979776 SLC35B4 0.86 16.11 0.66 1.27e-43 Mean platelet volume; LUSC cis rs11690935 0.959 rs7562356 chr2:172626611 C/G cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.88 -0.63 9.18e-39 Schizophrenia; LUSC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg23158103 chr7:148848205 ZNF398 -0.45 -7.28 -0.37 2.42e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg22681709 chr2:178499509 PDE11A -0.57 -11.33 -0.53 2.19e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg20607287 chr7:12443886 VWDE -0.61 -6.34 -0.33 7.27e-10 Coronary artery disease; LUSC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg17143192 chr8:8559678 CLDN23 0.6 8.66 0.43 2.05e-16 Obesity-related traits; LUSC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg14552801 chr7:65878734 NA 0.46 6.63 0.34 1.3100000000000001e-10 Aortic root size; LUSC cis rs7647973 0.710 rs6797299 chr3:49609794 G/T cg07636037 chr3:49044803 WDR6 0.55 5.69 0.3 2.82e-8 Menarche (age at onset); LUSC trans rs853679 0.607 rs35345226 chr6:28091580 A/G cg01620082 chr3:125678407 NA -0.85 -7.21 -0.37 3.87e-12 Depression; LUSC cis rs7940866 0.903 rs7942900 chr11:130839244 G/A cg12179176 chr11:130786555 SNX19 0.58 9.0 0.44 1.81e-17 Schizophrenia; LUSC cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg00645731 chr22:42541494 CYP2D7P1 -0.28 -5.74 -0.3 2.14e-8 Cognitive function; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.04 0.55 5.81e-28 Prudent dietary pattern; LUSC cis rs3791556 0.853 rs35245395 chr2:240107661 C/T cg03281426 chr2:240109471 HDAC4 0.53 7.43 0.38 8.95e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7312933 0.558 rs1051453 chr12:42852217 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.72 0.34 8.09e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg24060327 chr5:131705240 SLC22A5 -0.43 -7.15 -0.36 5.49e-12 Blood metabolite levels; LUSC cis rs1065852 0.906 rs5751232 chr22:42564304 C/T cg00645731 chr22:42541494 CYP2D7P1 0.6 10.04 0.48 6.9299999999999992e-21 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs3126085 1.000 rs3126085 chr1:152300817 G/A cg26876637 chr1:152193138 HRNR -0.45 -5.83 -0.3 1.27e-8 Atopic dermatitis; LUSC cis rs7822232 1.000 rs7822232 chr8:145145687 A/C cg10734432 chr8:145180544 NA -0.68 -5.96 -0.31 6.29e-9 Blood metabolite levels; LUSC trans rs2243480 1.000 rs13310597 chr7:65598540 A/G cg10756647 chr7:56101905 PSPH 0.87 8.94 0.44 2.62e-17 Diabetic kidney disease; LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg16325326 chr1:53192061 ZYG11B -0.89 -16.42 -0.67 7.56e-45 Monocyte count; LUSC cis rs11105306 1 rs11105306 chr12:89897388 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.38 -0.37 1.28e-12 NT-proBNP levels in acute coronary syndrome; LUSC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg06618935 chr21:46677482 NA -0.37 -7.27 -0.37 2.62e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs459571 0.959 rs461462 chr9:136911272 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -12.26 -0.56 8.72e-29 Platelet distribution width; LUSC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg20203395 chr5:56204925 C5orf35 -0.57 -8.07 -0.4 1.3e-14 Coronary artery disease; LUSC cis rs7937682 0.889 rs497111 chr11:111499512 G/A cg09085632 chr11:111637200 PPP2R1B -1.12 -18.16 -0.7 9.73e-52 Primary sclerosing cholangitis; LUSC trans rs4714291 0.698 rs2983144 chr6:40046724 G/A cg02267698 chr19:7991119 CTXN1 -0.55 -7.99 -0.4 2.25e-14 Strep throat; LUSC cis rs9517320 1.000 rs7996093 chr13:99133092 T/C cg20487152 chr13:99095054 FARP1 0.34 6.23 0.32 1.38e-9 Longevity; LUSC cis rs7605827 0.930 rs9287663 chr2:15596076 T/G cg19274914 chr2:15703543 NA 0.47 9.02 0.44 1.51e-17 Educational attainment (years of education); LUSC trans rs1941687 0.563 rs9953034 chr18:31335294 A/G cg27147174 chr7:100797783 AP1S1 -0.55 -8.59 -0.43 3.42e-16 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg10755058 chr3:40428713 ENTPD3 0.35 5.78 0.3 1.69e-8 Renal cell carcinoma; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg26767954 chr21:43638975 ABCG1 0.39 5.98 0.31 5.75e-9 Asthma; LUSC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg11062466 chr8:58055876 NA 0.59 7.34 0.37 1.65e-12 Developmental language disorder (linguistic errors); LUSC cis rs1346 0.552 rs10791821 chr11:65368323 A/G cg17120908 chr11:65337727 SSSCA1 0.43 6.11 0.32 2.79e-9 Vertical cup-disc ratio;Optic cup area; LUSC cis rs4319547 0.695 rs1973463 chr12:122938003 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.44 -0.46 6.68e-19 Body mass index; LUSC cis rs2985684 0.894 rs2883436 chr14:50013822 T/C cg04989706 chr14:50066350 PPIL5 -0.46 -6.05 -0.31 3.99e-9 Carotid intima media thickness; LUSC cis rs2273669 0.667 rs6899723 chr6:109362749 T/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs7100689 0.646 rs10400045 chr10:82077032 A/G cg00277334 chr10:82204260 NA -0.58 -8.73 -0.43 1.25e-16 Post bronchodilator FEV1; LUSC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg14541582 chr5:601475 NA -0.37 -5.65 -0.3 3.43e-8 Lung disease severity in cystic fibrosis; LUSC cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.55 0.83 5.42e-88 Chronic sinus infection; LUSC cis rs73206853 0.841 rs57726737 chr12:110843701 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 6.78 0.35 5.52e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.71 -0.3 2.53e-8 Tonsillectomy; LUSC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg07636037 chr3:49044803 WDR6 -0.68 -8.3 -0.41 2.55e-15 Menarche (age at onset); LUSC cis rs11048434 0.736 rs2041625 chr12:9112005 C/T cg13575925 chr12:9217583 LOC144571 0.35 6.66 0.34 1.12e-10 Sjögren's syndrome; LUSC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg08847533 chr14:75593920 NEK9 -0.81 -14.58 -0.62 1.31e-37 Height; LUSC cis rs2806561 0.704 rs2746560 chr1:23526279 G/A cg12483005 chr1:23474871 LUZP1 0.45 6.96 0.36 1.82e-11 Height; LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg13560548 chr3:10150139 C3orf24 -0.52 -7.65 -0.39 2.14e-13 Alzheimer's disease; LUSC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs2439831 0.557 rs13329084 chr15:44151063 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.8 -6.75 -0.35 6.46e-11 Lung cancer in ever smokers; LUSC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs2444217 0.872 rs2531977 chr16:4043701 C/G cg09300795 chr16:4042428 ADCY9 0.41 7.34 0.37 1.65e-12 Body mass index; LUSC cis rs6840360 0.571 rs12647566 chr4:152482525 C/T cg22705602 chr4:152727874 NA -0.34 -6.8 -0.35 4.74e-11 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12595990 chr12:49351331 ARF3 -0.52 -6.29 -0.33 1.02e-9 Bipolar disorder and schizophrenia; LUSC cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.25 -0.45 2.85e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg04576048 chr1:205797593 PM20D1 0.33 6.06 0.31 3.6e-9 Menarche (age at onset); LUSC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg09165964 chr15:75287851 SCAMP5 0.47 7.11 0.36 6.9e-12 Breast cancer; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg00887547 chr12:118811020 TAOK3 0.5 5.96 0.31 6.29e-9 Cognitive function;Information processing speed; LUSC cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg09184832 chr6:79620586 NA -0.43 -7.01 -0.36 1.29e-11 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.958 rs12196175 chr6:86779370 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.77 -0.35 5.91e-11 Response to antipsychotic treatment; LUSC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.95e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg17971929 chr21:40555470 PSMG1 0.74 12.4 0.56 2.66e-29 Cognitive function; LUSC cis rs3820928 0.874 rs13423714 chr2:227896652 C/G cg11843606 chr2:227700838 RHBDD1 0.49 7.13 0.36 6.36e-12 Pulmonary function; LUSC cis rs3105593 0.543 rs28582911 chr15:50729629 G/A cg08437265 chr15:50716283 USP8 0.4 5.8 0.3 1.55e-8 QT interval; LUSC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg02569458 chr12:86230093 RASSF9 0.48 8.0 0.4 2.01e-14 Major depressive disorder; LUSC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg10909506 chr17:38081995 ORMDL3 0.33 5.85 0.3 1.19e-8 Self-reported allergy; LUSC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg20821713 chr7:1055600 C7orf50 -0.56 -7.39 -0.37 1.2e-12 Bronchopulmonary dysplasia; LUSC cis rs3784262 1.000 rs4646586 chr15:58305344 C/A cg12031962 chr15:58353849 ALDH1A2 -0.33 -6.04 -0.31 4.18e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.52 -0.34 2.58e-10 Lung cancer; LUSC cis rs2404602 0.532 rs12591100 chr15:76700801 C/A cg23625390 chr15:77176239 SCAPER -0.53 -8.34 -0.42 1.94e-15 Blood metabolite levels; LUSC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg19230755 chr7:65878503 NA 0.41 5.75 0.3 2e-8 Aortic root size; LUSC cis rs9309473 0.950 rs10189885 chr2:73877055 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.44 -0.33 4.07e-10 Metabolite levels; LUSC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg17507749 chr15:85114479 UBE2QP1 0.68 8.55 0.42 4.36e-16 Schizophrenia; LUSC cis rs72634258 0.945 rs12745223 chr1:8094978 C/T cg00042356 chr1:8021962 PARK7 0.81 9.85 0.47 2.83e-20 Inflammatory bowel disease; LUSC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg08219700 chr8:58056026 NA 0.49 6.06 0.31 3.61e-9 Developmental language disorder (linguistic errors); LUSC cis rs637571 0.584 rs7107912 chr11:65603252 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.45 -7.9 -0.4 3.95e-14 Eosinophil percentage of white cells; LUSC cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg13319975 chr6:146136371 FBXO30 0.48 7.3 0.37 2.09e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7095944 0.585 rs7080838 chr10:126419841 A/G cg08799069 chr10:126477246 METTL10 0.45 7.2 0.37 3.89e-12 Asthma; LUSC trans rs7618501 0.633 rs11130228 chr3:50003246 C/T cg21659725 chr3:3221576 CRBN 0.63 10.41 0.49 3.61e-22 Intelligence (multi-trait analysis); LUSC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.65 -0.39 2.22e-13 Height; LUSC cis rs2625529 0.689 rs2957742 chr15:72302894 C/G cg16672083 chr15:72433130 SENP8 0.49 8.08 0.4 1.2e-14 Red blood cell count; LUSC cis rs4478858 0.735 rs4622114 chr1:31772571 A/G cg00250761 chr1:31883323 NA -0.34 -8.46 -0.42 8.39e-16 Alcohol dependence; LUSC trans rs877282 0.733 rs7092976 chr10:756358 G/A cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC trans rs11992162 0.967 rs10088415 chr8:11830825 A/G cg08975724 chr8:8085496 FLJ10661 -0.5 -7.12 -0.36 6.56e-12 Monocyte count; LUSC cis rs62400317 0.859 rs4498350 chr6:45268438 C/T cg20913747 chr6:44695427 NA -0.45 -7.42 -0.38 9.93e-13 Total body bone mineral density; LUSC cis rs11677416 1.000 rs34015482 chr2:113525745 A/G cg27083787 chr2:113543245 IL1A 0.46 7.07 0.36 9.13e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg05283184 chr6:79620031 NA -0.55 -11.31 -0.53 2.57e-25 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.35 -0.69 1.61e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg03732007 chr1:2071316 PRKCZ -0.51 -9.06 -0.44 1.11e-17 Height; LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg14004847 chr7:1930337 MAD1L1 -0.67 -10.87 -0.51 9.44e-24 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.863 rs3775858 chr4:120486028 A/G cg09307838 chr4:120376055 NA 0.76 11.15 0.52 8.96e-25 Corneal astigmatism; LUSC cis rs9303401 0.659 rs35828828 chr17:56718205 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.52 0.59 1.62e-33 Cognitive test performance; LUSC cis rs10740039 0.804 rs1372714 chr10:62446398 C/T cg18175470 chr10:62150864 ANK3 -0.43 -6.54 -0.34 2.28e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12467847 0.931 rs2708931 chr2:113693878 C/G cg12858261 chr2:113808755 IL1F8 -0.4 -6.04 -0.31 4.02e-9 Response to amphetamines; LUSC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.71e-13 Electroencephalogram traits; LUSC cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.57 8.67 0.43 1.91e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9378688 1.000 rs9378687 chr6:2218835 A/G cg12303981 chr6:2244766 GMDS -0.5 -5.92 -0.31 8.1e-9 Caudate nucleus volume; LUSC cis rs6063312 1.000 rs11699576 chr20:47349878 A/C cg18078177 chr20:47281410 PREX1 0.63 7.64 0.39 2.38e-13 Tonometry; LUSC cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg24642439 chr20:33292090 TP53INP2 -0.53 -8.11 -0.41 9.53e-15 Glomerular filtration rate (creatinine); LUSC cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg05043794 chr9:111880884 C9orf5 -0.35 -7.4 -0.38 1.14e-12 Menarche (age at onset); LUSC cis rs2228479 0.681 rs7196840 chr16:89959647 A/G cg04013166 chr16:89971882 TCF25 0.62 7.24 0.37 3.1e-12 Skin colour saturation; LUSC trans rs4332037 0.615 rs62435127 chr7:1884937 A/G cg11693508 chr17:37793320 STARD3 0.53 6.56 0.34 2.04e-10 Bipolar disorder; LUSC trans rs9291683 0.609 rs12507050 chr4:10007305 G/T cg26043149 chr18:55253948 FECH 0.53 7.77 0.39 9.7e-14 Bone mineral density; LUSC cis rs6456156 0.766 rs150112 chr6:167509878 C/T cg06454157 chr6:167490870 NA 0.24 5.73 0.3 2.27e-8 Primary biliary cholangitis; LUSC trans rs11039798 0.660 rs717897 chr11:48375604 A/G cg03929089 chr4:120376271 NA -0.59 -6.26 -0.32 1.19e-9 Axial length; LUSC trans rs7615952 0.599 rs7631268 chr3:125755664 T/A cg07211511 chr3:129823064 LOC729375 -0.77 -9.85 -0.47 2.89e-20 Blood pressure (smoking interaction); LUSC cis rs929354 0.742 rs7784442 chr7:156934475 G/C cg05182265 chr7:156933206 UBE3C -0.59 -9.44 -0.46 6.62e-19 Body mass index; LUSC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg07716408 chr11:68623521 NA -0.32 -6.29 -0.33 9.79e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9660992 0.762 rs1172130 chr1:205244953 G/A cg21545522 chr1:205238299 TMCC2 0.48 9.09 0.45 9.26e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs11864453 0.826 rs12708928 chr16:72137227 C/A cg01557791 chr16:72042693 DHODH -0.5 -7.17 -0.37 4.87e-12 Fibrinogen levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04314218 chr1:43919181 HYI 0.68 6.05 0.31 3.98e-9 Cognitive performance; LUSC cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.55 0.65 2.12e-41 Bladder cancer; LUSC cis rs4356932 0.967 rs4241581 chr4:76962055 G/A cg00809888 chr4:76862425 NAAA 0.36 5.92 0.31 7.79e-9 Blood protein levels; LUSC cis rs2067615 0.542 rs7133161 chr12:107139540 A/G cg15890332 chr12:107067104 RFX4 0.35 6.39 0.33 5.71e-10 Heart rate; LUSC cis rs3105593 0.547 rs3131559 chr15:50780214 C/A cg08437265 chr15:50716283 USP8 0.41 5.9 0.31 8.98e-9 QT interval; LUSC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg15445000 chr17:37608096 MED1 0.39 6.71 0.34 8.27e-11 Glomerular filtration rate (creatinine); LUSC cis rs259282 0.605 rs2302970 chr19:33098632 G/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.65 9.67 0.47 1.13e-19 Schizophrenia; LUSC cis rs17401966 0.558 rs17402762 chr1:10414470 T/C cg19773385 chr1:10388646 KIF1B -0.37 -6.49 -0.33 3.04e-10 Hepatocellular carcinoma; LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC trans rs11992162 0.967 rs4840601 chr8:11828730 G/C cg27411982 chr8:10470053 RP1L1 0.49 7.65 0.39 2.13e-13 Monocyte count; LUSC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg09365446 chr1:150670422 GOLPH3L 0.48 7.05 0.36 1.02e-11 Melanoma; LUSC trans rs4649444 0.666 rs16858849 chr1:233339427 C/T cg15547662 chr1:26324823 PAFAH2 0.44 5.99 0.31 5.55e-9 Homeostasis model assessment of beta-cell function (dietary factor interaction); LUSC trans rs877282 0.853 rs7092652 chr10:756109 G/A cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg18230493 chr5:56204884 C5orf35 -0.86 -12.8 -0.57 8.47e-31 Initial pursuit acceleration; LUSC cis rs7927592 0.871 rs11228284 chr11:68322767 A/T cg16797656 chr11:68205561 LRP5 0.38 6.23 0.32 1.4e-9 Total body bone mineral density; LUSC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg13939156 chr17:80058883 NA -0.33 -6.42 -0.33 4.68e-10 Life satisfaction; LUSC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg07424592 chr7:64974309 NA 0.66 5.82 0.3 1.39e-8 Diabetic kidney disease; LUSC cis rs12760731 0.720 rs34194793 chr1:178329065 G/T cg00404053 chr1:178313656 RASAL2 0.57 6.07 0.32 3.44e-9 Obesity-related traits; LUSC cis rs9467773 0.838 rs3734540 chr6:26463321 A/C cg05738196 chr6:26577821 NA 0.67 11.23 0.52 4.97e-25 Intelligence (multi-trait analysis); LUSC cis rs2012796 0.956 rs6574646 chr14:81819809 A/G cg02996355 chr14:81879375 NA 0.5 7.24 0.37 3.08e-12 Night sleep phenotypes; LUSC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg03240473 chr21:43526662 UMODL1;C21orf128 -0.47 -7.36 -0.37 1.44e-12 IgG glycosylation; LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03934478 chr11:495069 RNH1 -0.85 -10.25 -0.49 1.32e-21 Body mass index; LUSC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg21724239 chr8:58056113 NA 0.8 9.24 0.45 3.07e-18 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs8058578 1.000 rs6565201 chr16:30747191 C/T cg05768032 chr16:30646687 NA 0.4 5.92 0.31 7.93e-9 Multiple myeloma; LUSC cis rs7726839 0.794 rs10053310 chr5:595661 C/G cg03128945 chr5:622914 CEP72 -0.45 -6.46 -0.33 3.69e-10 Obesity-related traits; LUSC cis rs61931739 0.500 rs7306435 chr12:34482933 A/G cg06521331 chr12:34319734 NA 0.41 6.41 0.33 4.97e-10 Morning vs. evening chronotype; LUSC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg05472934 chr7:22766657 IL6 0.5 7.84 0.39 6.13e-14 Lung cancer; LUSC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs868036 0.718 rs8030456 chr15:68076856 C/T cg05925327 chr15:68127851 NA -0.43 -6.95 -0.36 1.91e-11 Restless legs syndrome; LUSC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg26727032 chr16:67993705 SLC12A4 -0.44 -5.87 -0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg16624210 chr5:671434 TPPP 0.49 6.27 0.32 1.09e-9 Lung disease severity in cystic fibrosis; LUSC cis rs259282 0.692 rs35972270 chr19:33128457 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.69 10.51 0.5 1.66e-22 Schizophrenia; LUSC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg07870213 chr5:140052090 DND1 0.72 10.74 0.51 2.57e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs887829 0.569 rs6711351 chr2:234634916 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.82 -0.39 6.95e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs1371867 0.775 rs3020183 chr8:101233297 A/T cg06636551 chr8:101224915 SPAG1 0.46 8.47 0.42 7.81e-16 Atrioventricular conduction; LUSC trans rs3749237 0.964 rs7431078 chr3:49808190 G/A cg21659725 chr3:3221576 CRBN 0.62 8.77 0.43 9.04e-17 Resting heart rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23043438 chr9:103115132 TEX10 -0.44 -6.62 -0.34 1.4e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg14784868 chr12:69753453 YEATS4 0.92 16.31 0.67 2.09e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs877282 0.945 rs11253388 chr10:787852 A/G cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs4243830 0.826 rs3908553 chr1:6621921 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.94 9.13 0.45 6.58e-18 Body mass index; LUSC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.92e-10 Life satisfaction; LUSC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg06008330 chr7:65541103 ASL -0.4 -6.23 -0.32 1.43e-9 Aortic root size; LUSC cis rs921968 0.509 rs3856548 chr2:219398164 C/T cg02176678 chr2:219576539 TTLL4 -0.74 -14.41 -0.62 6.01e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs4566357 0.615 rs4675140 chr2:227908665 C/T cg11843606 chr2:227700838 RHBDD1 -0.55 -8.28 -0.41 2.96e-15 Coronary artery disease; LUSC cis rs11608355 1.000 rs7970482 chr12:109862335 G/A cg05360138 chr12:110035743 NA 0.47 6.43 0.33 4.52e-10 Neuroticism; LUSC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.31 -0.33 9.11e-10 Lung cancer; LUSC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg24110177 chr3:50126178 RBM5 0.57 9.21 0.45 3.63e-18 Intelligence (multi-trait analysis); LUSC cis rs10740039 0.516 rs1442551 chr10:62324491 T/C cg18175470 chr10:62150864 ANK3 -0.45 -6.78 -0.35 5.48e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs804280 0.509 rs13276433 chr8:11783036 A/G cg08975724 chr8:8085496 FLJ10661 0.48 7.01 0.36 1.34e-11 Myopia (pathological); LUSC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg19622623 chr12:86230825 RASSF9 -0.44 -6.26 -0.32 1.15e-9 Major depressive disorder; LUSC cis rs9287719 0.967 rs7566875 chr2:10754792 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg23788917 chr6:8435910 SLC35B3 -0.47 -5.98 -0.31 5.76e-9 Motion sickness; LUSC cis rs9611519 0.929 rs9611509 chr22:41565827 A/G cg03806693 chr22:41940476 POLR3H -0.55 -7.61 -0.38 2.84e-13 Neuroticism; LUSC cis rs4363385 0.693 rs6690672 chr1:152930564 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -6.73 -0.35 7.32e-11 Inflammatory skin disease; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.59 9.59 0.46 2.07e-19 Lymphocyte counts; LUSC cis rs9914988 0.943 rs4794838 chr17:27131095 T/C cg09479241 chr17:27052676 TLCD1 0.44 5.94 0.31 7.3e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2573652 0.755 rs1469830 chr15:100517403 G/T cg00587665 chr15:100533223 ADAMTS17 0.37 6.08 0.32 3.32e-9 Height; LUSC cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg26384229 chr12:38710491 ALG10B 0.89 14.85 0.63 1.19e-38 Bladder cancer; LUSC cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.31 0.37 1.93e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4589502 1.000 rs79390908 chr15:67130924 C/T cg09911534 chr15:67153556 NA -0.69 -7.19 -0.37 4.15e-12 Lung cancer (smoking interaction); LUSC cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC cis rs1008375 0.966 rs3796812 chr4:17582051 G/A cg16339924 chr4:17578868 LAP3 0.6 9.33 0.45 1.53e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs72960926 0.744 rs55764691 chr6:74924388 T/C cg03266952 chr6:74778945 NA -0.84 -7.01 -0.36 1.34e-11 Metabolite levels (MHPG); LUSC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg08859206 chr1:53392774 SCP2 -0.54 -9.68 -0.47 1.07e-19 Monocyte count; LUSC cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg16386425 chr10:429943 DIP2C -0.39 -6.11 -0.32 2.78e-9 Psychosis in Alzheimer's disease; LUSC cis rs908922 0.676 rs4240884 chr1:152529792 C/T cg20991723 chr1:152506922 NA -0.48 -9.04 -0.44 1.28e-17 Hair morphology; LUSC cis rs72781680 0.948 rs72796385 chr2:24170360 T/A cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg07061783 chr6:25882402 NA -0.38 -5.86 -0.31 1.14e-8 Blood metabolite levels; LUSC cis rs73206853 0.764 rs56205958 chr12:111027361 G/C cg12870014 chr12:110450643 ANKRD13A 0.69 7.58 0.38 3.37e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9303401 0.659 rs12952325 chr17:56899371 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.47 0.59 2.6e-33 Cognitive test performance; LUSC trans rs6598955 0.671 rs10902732 chr1:26606174 A/C cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.53 -0.42 5.13e-16 Obesity-related traits; LUSC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg25566285 chr7:158114605 PTPRN2 -0.34 -6.28 -0.32 1.06e-9 Calcium levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13315471 chr2:27258494 TMEM214 -0.42 -6.37 -0.33 6.29e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11871801 0.560 rs1905339 chr17:40582296 T/C cg16308533 chr17:40838983 CNTNAP1 0.37 5.8 0.3 1.52e-8 Crohn's disease; LUSC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg11644478 chr21:40555479 PSMG1 0.59 9.53 0.46 3.39e-19 Cognitive function; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg11060661 chr22:24314208 DDT;DDTL 0.46 7.53 0.38 4.75e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs2299587 0.607 rs2237848 chr8:17874604 A/C cg01800426 chr8:17659068 MTUS1 -0.43 -5.69 -0.3 2.82e-8 Economic and political preferences; LUSC cis rs9326248 1.000 rs7107152 chr11:117056080 C/T cg20608306 chr11:116969690 SIK3 -0.36 -6.01 -0.31 4.85e-9 Blood protein levels; LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 6.37 0.33 6.1e-10 Electroencephalogram traits; LUSC cis rs12908161 1.000 rs35960805 chr15:85343980 T/G cg12863693 chr15:85201151 NMB 0.39 8.1 0.41 1.07e-14 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14467103 chr5:154317806 GEMIN5 -0.42 -6.18 -0.32 1.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4595586 0.545 rs12833238 chr12:39373898 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.08e-9 Morning vs. evening chronotype; LUSC cis rs11098499 0.708 rs11732686 chr4:120252330 C/A cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg00810483 chr4:3375144 RGS12 -0.3 -5.7 -0.3 2.68e-8 Serum sulfate level; LUSC cis rs6489785 0.522 rs2701177 chr12:121344490 G/T cg02419362 chr12:121203948 SPPL3 -0.39 -6.78 -0.35 5.33e-11 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2732480 0.557 rs2732454 chr12:48719677 T/C cg04545296 chr12:48745243 ZNF641 0.35 6.34 0.33 7.61e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg12310025 chr6:25882481 NA -0.42 -7.42 -0.38 9.47e-13 Height; LUSC cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.13 0.55 2.73e-28 Colorectal cancer; LUSC cis rs12422267 0.536 rs61944635 chr12:132575652 C/T cg05134918 chr12:132603531 EP400NL -0.57 -6.58 -0.34 1.83e-10 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg22800045 chr5:56110881 MAP3K1 0.68 8.4 0.42 1.34e-15 Initial pursuit acceleration; LUSC cis rs713587 0.967 rs713586 chr2:25158008 A/G cg15423357 chr2:25149977 NA 0.43 8.84 0.44 5.73e-17 Body mass index in non-asthmatics; LUSC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg25319279 chr11:5960081 NA -0.39 -5.87 -0.31 1.05e-8 DNA methylation (variation); LUSC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg15839431 chr19:19639596 YJEFN3 0.44 6.19 0.32 1.78e-9 Tonsillectomy; LUSC cis rs1005224 0.963 rs11623813 chr14:76138194 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.4 -5.82 -0.3 1.37e-8 Large artery stroke; LUSC cis rs1451375 0.617 rs896307 chr7:50569060 T/C cg18232548 chr7:50535776 DDC -0.54 -7.5 -0.38 5.76e-13 Malaria; LUSC cis rs7937682 0.632 rs7112886 chr11:111743232 T/C cg09085632 chr11:111637200 PPP2R1B 0.93 12.34 0.56 4.58e-29 Primary sclerosing cholangitis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04673371 chr7:131012253 MKLN1 -0.45 -6.02 -0.31 4.5e-9 Hepatitis; LUSC cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg01256987 chr12:42539512 GXYLT1 -0.46 -8.4 -0.42 1.28e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs317689 1.000 rs317689 chr12:69727190 G/A cg14784868 chr12:69753453 YEATS4 0.56 7.2 0.37 3.97e-12 Response to diuretic therapy; LUSC trans rs2392780 0.512 rs373701 chr8:128334992 C/A cg10897648 chr18:56338258 MALT1 -0.41 -6.17 -0.32 1.92e-9 Breast cancer (early onset); LUSC cis rs9788682 0.748 rs2456020 chr15:78868398 C/T cg06917634 chr15:78832804 PSMA4 -0.54 -6.74 -0.35 6.96e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1949733 0.636 rs16842498 chr4:8539529 C/T cg13073564 chr4:8508604 NA 0.35 6.34 0.33 7.5e-10 Response to antineoplastic agents; LUSC cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg23093090 chr10:104574429 C10orf26 -0.4 -6.8 -0.35 4.9e-11 Arsenic metabolism; LUSC cis rs12956009 0.583 rs1821446 chr18:44894422 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.06 0.31 3.6e-9 Educational attainment (years of education); LUSC cis rs11585357 0.895 rs72633806 chr1:17617943 A/G cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC cis rs11190604 1.000 rs2495742 chr10:102331364 C/T cg07080220 chr10:102295463 HIF1AN 0.67 8.75 0.43 1.11e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2274273 0.624 rs8005450 chr14:55799165 A/T cg04306507 chr14:55594613 LGALS3 0.48 9.69 0.47 1e-19 Protein biomarker; LUSC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg13607699 chr17:42295918 UBTF -0.58 -8.73 -0.43 1.2e-16 Total body bone mineral density; LUSC cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg11244672 chr19:19639970 YJEFN3 0.64 8.0 0.4 2.09e-14 Bipolar disorder; LUSC trans rs57046232 0.511 rs6054143 chr20:6334697 C/T cg21095983 chr6:86352623 SYNCRIP 0.47 7.02 0.36 1.26e-11 Colorectal cancer; LUSC cis rs11214589 0.620 rs34601878 chr11:113260898 G/A cg14159747 chr11:113255604 NA 0.29 7.66 0.39 1.97e-13 Neuroticism; LUSC cis rs10208940 0.764 rs6737302 chr2:68782837 A/G cg12452813 chr2:68675892 NA 0.56 5.81 0.3 1.45e-8 Urate levels in lean individuals; LUSC trans rs11098499 0.863 rs2306456 chr4:120472422 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs67539049 1.000 rs67932868 chr8:11303445 G/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.41 -6.33 -0.33 7.98e-10 Itch intensity from mosquito bite; LUSC cis rs11997175 0.550 rs10954943 chr8:33815972 A/G ch.8.33884649F chr8:33765107 NA 0.44 6.8 0.35 4.83e-11 Body mass index; LUSC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg13939156 chr17:80058883 NA -0.34 -6.64 -0.34 1.28e-10 Life satisfaction; LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.37 -0.42 1.56e-15 Mean platelet volume; LUSC cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg11645453 chr3:52864694 ITIH4 0.5 11.24 0.52 4.42e-25 Schizophrenia; LUSC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg18230493 chr5:56204884 C5orf35 0.85 12.67 0.57 2.54e-30 Initial pursuit acceleration; LUSC cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.3 0.56 6.22e-29 Motion sickness; LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg14092988 chr3:52407081 DNAH1 0.32 6.2 0.32 1.65e-9 Bipolar disorder; LUSC cis rs10876993 0.893 rs1678504 chr12:58085498 G/C cg18357645 chr12:58087776 OS9 0.58 8.73 0.43 1.27e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs6547741 0.743 rs7564625 chr2:27862397 C/T cg12559939 chr2:27858050 GPN1 -0.41 -6.21 -0.32 1.58e-9 Oral cavity cancer; LUSC cis rs9807989 0.839 rs13392100 chr2:102982094 C/A cg03938978 chr2:103052716 IL18RAP 0.31 5.68 0.3 2.87e-8 Asthma; LUSC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg23205692 chr1:25664452 TMEM50A -0.39 -5.77 -0.3 1.78e-8 Erythrocyte sedimentation rate; LUSC cis rs1801251 1.000 rs6717841 chr2:233590255 C/T cg08000102 chr2:233561755 GIGYF2 0.68 11.42 0.53 1.04e-25 Coronary artery disease; LUSC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg18479299 chr3:125709523 NA -0.49 -5.67 -0.3 3.05e-8 Blood pressure (smoking interaction); LUSC cis rs2120019 0.608 rs8042558 chr15:75320433 G/T cg17294928 chr15:75287854 SCAMP5 -0.88 -12.84 -0.58 5.81e-31 Blood trace element (Zn levels); LUSC cis rs7223966 1.000 rs9899491 chr17:61934384 G/C cg00945038 chr17:61921165 SMARCD2 0.38 5.77 0.3 1.8e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg13939156 chr17:80058883 NA -0.32 -6.37 -0.33 6.43e-10 Life satisfaction; LUSC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg21856205 chr7:94953877 PON1 -0.36 -5.69 -0.3 2.72e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs8072100 0.967 rs7221548 chr17:45582952 T/C cg03886242 chr7:26192032 NFE2L3 0.36 5.96 0.31 6.57e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4319547 0.695 rs4758666 chr12:122902840 C/T cg23029597 chr12:123009494 RSRC2 -0.63 -8.15 -0.41 7.2e-15 Body mass index; LUSC cis rs61931739 0.500 rs11053273 chr12:34547255 C/T cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg05340658 chr4:99064831 C4orf37 -0.6 -9.4 -0.46 8.73e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs6580649 0.941 rs4141065 chr12:48523499 G/A cg24011408 chr12:48396354 COL2A1 -0.47 -6.34 -0.33 7.54e-10 Lung cancer; LUSC cis rs9309711 0.698 rs9750503 chr2:3491772 A/G cg10845886 chr2:3471009 TTC15 0.55 7.2 0.37 4.09e-12 Neurofibrillary tangles; LUSC cis rs76878669 0.561 rs4244813 chr11:66129488 G/C cg24851651 chr11:66362959 CCS -0.36 -5.73 -0.3 2.25e-8 Educational attainment (years of education); LUSC trans rs877282 1.000 rs10904552 chr10:774326 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.82 -0.35 4.19e-11 Uric acid levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14983362 chr11:118901610 SLC37A4 -0.42 -6.13 -0.32 2.5e-9 Electrocardiographic conduction measures; LUSC cis rs56399783 0.901 rs73049305 chr7:2778755 C/T cg14895029 chr7:2775587 GNA12 0.52 5.72 0.3 2.43e-8 Childhood ear infection; LUSC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg20573242 chr4:122745356 CCNA2 0.63 9.34 0.46 1.36e-18 Type 2 diabetes; LUSC cis rs68170813 0.559 rs77641084 chr7:106970522 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.72 -0.3 2.39e-8 Coronary artery disease; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg03354898 chr7:1950403 MAD1L1 -0.43 -8.64 -0.43 2.38e-16 Bipolar disorder and schizophrenia; LUSC cis rs1113500 0.862 rs2336129 chr1:108640669 A/G cg11967332 chr1:108735228 SLC25A24 -0.39 -5.95 -0.31 6.86e-9 Growth-regulated protein alpha levels; LUSC cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg23583168 chr7:148888333 NA -0.89 -17.57 -0.69 2.08e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10754283 0.901 rs10922684 chr1:90117934 T/C cg21401794 chr1:90099060 LRRC8C 0.61 8.77 0.43 9.6e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.59 0.34 1.77e-10 Lung cancer in ever smokers; LUSC cis rs3092073 0.624 rs11696623 chr20:44580380 C/T cg23303369 chr20:44641161 MMP9 0.37 6.42 0.33 4.77e-10 Intelligence (multi-trait analysis); LUSC trans rs800082 0.516 rs12486830 chr3:144228339 A/T cg24215973 chr2:240111563 HDAC4 0.44 6.64 0.34 1.26e-10 Smoking behavior; LUSC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.85 0.31 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs4808199 0.793 rs12459676 chr19:19425141 A/T cg03709012 chr19:19516395 GATAD2A 0.94 10.64 0.5 5.74e-23 Nonalcoholic fatty liver disease; LUSC trans rs6598955 0.627 rs7550127 chr1:26592871 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.69 -0.43 1.6e-16 Obesity-related traits; LUSC cis rs9322193 0.567 rs7742692 chr6:150213499 A/G cg07701084 chr6:150067640 NUP43 0.47 7.08 0.36 8.6e-12 Lung cancer; LUSC cis rs3784262 1.000 rs4646619 chr15:58258342 A/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.8 -0.3 1.58e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs858239 0.539 rs28624974 chr7:23188936 T/C cg23682824 chr7:23144976 KLHL7 0.4 5.71 0.3 2.52e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs4285028 0.747 rs12496318 chr3:121561500 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.89 10.67 0.5 4.4e-23 Multiple sclerosis; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg15147215 chr3:52552868 STAB1 -0.29 -5.66 -0.3 3.24e-8 Electroencephalogram traits; LUSC cis rs1005224 0.929 rs11625260 chr14:76162293 G/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.64 -8.87 -0.44 4.45e-17 Large artery stroke; LUSC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg02782426 chr3:40428986 ENTPD3 0.32 6.17 0.32 2e-9 Renal cell carcinoma; LUSC cis rs11098499 0.863 rs12508173 chr4:120318526 T/C cg24375607 chr4:120327624 NA 0.77 11.3 0.53 2.73e-25 Corneal astigmatism; LUSC cis rs6696846 0.777 rs9651228 chr1:205049383 A/G cg00857998 chr1:205179979 DSTYK 0.57 8.85 0.44 5.28e-17 Red blood cell count; LUSC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg20135002 chr11:47629003 NA 0.51 7.99 0.4 2.26e-14 Subjective well-being; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg11843238 chr5:131593191 PDLIM4 0.5 8.73 0.43 1.21e-16 Acylcarnitine levels; LUSC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg03929089 chr4:120376271 NA 0.95 15.05 0.64 1.88e-39 Height; LUSC cis rs2806561 0.734 rs2806564 chr1:23506685 T/C cg19743168 chr1:23544995 NA 0.41 8.05 0.4 1.51e-14 Height; LUSC cis rs4363385 0.818 rs9659389 chr1:152989844 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.54e-13 Inflammatory skin disease; LUSC cis rs10876993 0.890 rs774888 chr12:58036506 A/G cg15848620 chr12:58087721 OS9 -0.53 -7.47 -0.38 6.89e-13 Celiac disease or Rheumatoid arthritis; LUSC trans rs11264213 0.901 rs72661628 chr1:36406547 A/G cg05872835 chr6:75796125 COL12A1 0.51 5.97 0.31 5.97e-9 Schizophrenia; LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.93 0.51 5.58e-24 Menopause (age at onset); LUSC cis rs7220401 0.512 rs2289629 chr17:27959903 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.14 0.45 6.22e-18 Coronary artery disease; LUSC cis rs10788972 0.508 rs6691549 chr1:54480903 A/G cg25741118 chr1:54482237 LDLRAD1 -0.3 -6.66 -0.34 1.14e-10 Parkinson disease and lewy body pathology; LUSC cis rs806215 0.906 rs806195 chr7:127249178 A/G cg25922125 chr7:127225783 GCC1 0.57 7.17 0.37 4.96e-12 Type 2 diabetes; LUSC cis rs12760731 0.668 rs10913548 chr1:178372286 G/A cg00404053 chr1:178313656 RASAL2 0.64 6.55 0.34 2.22e-10 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21467513 chr18:33709444 SLC39A6;ELP2 -0.46 -6.75 -0.35 6.75e-11 Electrocardiographic conduction measures; LUSC cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg24812749 chr6:127587940 RNF146 0.81 11.83 0.54 3.23e-27 Breast cancer; LUSC cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg25801113 chr15:45476975 SHF 0.36 7.32 0.37 1.82e-12 Uric acid levels; LUSC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.52e-24 Aortic root size; LUSC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg18876405 chr7:65276391 NA 0.54 8.36 0.42 1.69e-15 Aortic root size; LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg06022373 chr22:39101656 GTPBP1 0.88 14.7 0.63 4.66e-38 Menopause (age at onset); LUSC trans rs10432489 0.708 rs10189224 chr2:181764318 A/C cg04744134 chr19:8408128 KANK3 -0.85 -6.73 -0.35 7.49e-11 QT interval; LUSC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.4 -8.0 -0.4 2.04e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs6696846 0.936 rs6662930 chr1:205041465 T/C cg00857998 chr1:205179979 DSTYK 0.65 9.82 0.47 3.69e-20 Red blood cell count; LUSC cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg05294307 chr14:35346193 BAZ1A -0.63 -7.57 -0.38 3.76e-13 Psoriasis; LUSC cis rs3741151 1.000 rs7949364 chr11:73041077 A/G cg17517138 chr11:73019481 ARHGEF17 0.95 8.89 0.44 3.99e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg02574844 chr11:5959923 NA -0.45 -6.34 -0.33 7.63e-10 DNA methylation (variation); LUSC trans rs7739264 0.602 rs2223362 chr6:19778171 C/A cg13431028 chr2:169073609 STK39 0.38 6.4 0.33 5.22e-10 Endometriosis; LUSC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg06212747 chr3:49208901 KLHDC8B 0.44 6.04 0.31 4.17e-9 Parkinson's disease; LUSC cis rs6964587 1.000 rs10236397 chr7:91691601 C/T cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC trans rs6502050 0.805 rs7406682 chr17:80084368 C/T cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg00310523 chr12:86230176 RASSF9 0.54 10.06 0.48 5.54e-21 Major depressive disorder; LUSC cis rs425277 1.000 rs421992 chr1:2077260 C/T cg03732007 chr1:2071316 PRKCZ 0.47 7.58 0.38 3.49e-13 Height; LUSC cis rs6120849 0.754 rs8501 chr20:33590584 T/C cg24642439 chr20:33292090 TP53INP2 0.62 6.85 0.35 3.66e-11 Protein C levels; LUSC cis rs9815354 0.556 rs116717051 chr3:42027411 G/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs9462027 0.651 rs6940395 chr6:34736553 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.91 -0.31 8.62e-9 Systemic lupus erythematosus; LUSC cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg26373071 chr5:1325741 CLPTM1L 0.42 7.64 0.39 2.39e-13 Lung cancer; LUSC cis rs7590720 0.704 rs7603645 chr2:216876949 C/G cg12620499 chr2:216877984 MREG 0.97 17.77 0.7 3.26e-50 Alcohol dependence; LUSC trans rs1814175 0.817 rs1851860 chr11:49861310 A/C cg03929089 chr4:120376271 NA -1.03 -20.25 -0.74 4.78e-60 Height; LUSC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg18827107 chr12:86230957 RASSF9 -0.44 -6.56 -0.34 2.07e-10 Major depressive disorder; LUSC cis rs7818345 1.000 rs11991105 chr8:19290655 C/T cg11303988 chr8:19266685 CSGALNACT1 0.37 7.29 0.37 2.28e-12 Language performance in older adults (adjusted for episodic memory); LUSC trans rs561341 1.000 rs550264 chr17:30317540 G/T cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC trans rs1997103 1.000 rs2177804 chr7:55410302 G/A cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7589342 0.628 rs62152201 chr2:106411664 C/T cg14210321 chr2:106509881 NCK2 -0.46 -5.87 -0.31 1.04e-8 Addiction; LUSC cis rs988712 0.622 rs7103411 chr11:27700125 C/T cg10635145 chr11:27742435 BDNF 0.48 6.63 0.34 1.3100000000000001e-10 Obesity; LUSC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg22823121 chr1:150693482 HORMAD1 0.49 7.13 0.36 6.37e-12 Melanoma; LUSC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg09650180 chr20:62225654 GMEB2 -0.66 -9.68 -0.47 1.1e-19 Glioblastoma; LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg19717773 chr7:2847554 GNA12 -0.35 -5.73 -0.3 2.19e-8 Height; LUSC cis rs9326248 0.520 rs1446105 chr11:116798544 C/T cg20608306 chr11:116969690 SIK3 0.36 6.7 0.34 9e-11 Blood protein levels; LUSC cis rs7089973 0.872 rs7075888 chr10:116627117 C/T cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 5.96e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9650657 0.615 rs6601536 chr8:10696311 C/G cg27411982 chr8:10470053 RP1L1 -0.34 -5.68 -0.3 2.91e-8 Neuroticism; LUSC cis rs13401104 0.796 rs56338351 chr2:237119104 G/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs6469656 1.000 rs7830860 chr8:117652174 C/T cg24004040 chr8:117650383 NA 0.42 6.51 0.34 2.75e-10 Colorectal cancer; LUSC cis rs6028335 0.674 rs66526549 chr20:37588360 A/G cg27552599 chr20:37590471 DHX35 0.45 5.65 0.3 3.4e-8 Alcohol and nicotine co-dependence; LUSC trans rs9747201 1.000 rs62078307 chr17:80090053 G/T cg07393940 chr7:158741817 NA -0.51 -8.05 -0.4 1.43e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg11766577 chr21:47581405 C21orf56 0.54 8.49 0.42 6.73e-16 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.73 -0.35 7.4e-11 Lung cancer; LUSC cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg24450063 chr1:156163899 SLC25A44 1.18 29.84 0.85 3.02e-96 Testicular germ cell tumor; LUSC cis rs983392 0.766 rs476722 chr11:59913806 T/C cg24026212 chr11:59952134 MS4A6A -0.31 -5.67 -0.3 3.14e-8 Alzheimer's disease (late onset); LUSC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg15448220 chr1:150897856 SETDB1 0.41 6.02 0.31 4.48e-9 Melanoma; LUSC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg11764359 chr7:65958608 NA 0.69 11.16 0.52 8.79e-25 Aortic root size; LUSC cis rs12541635 0.677 rs13439705 chr8:106967268 T/C cg10147462 chr8:107024639 NA 0.65 13.14 0.58 4.55e-32 Age of smoking initiation; LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs4903214 0.895 rs10142706 chr14:74717304 A/G cg08255017 chr14:74727001 VSX2 -0.44 -5.91 -0.31 8.43e-9 Inflammatory bowel disease; LUSC cis rs1847202 0.826 rs11925587 chr3:72952227 A/G cg25664220 chr3:72788482 NA 0.4 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg14668632 chr7:2872130 GNA12 -0.45 -6.59 -0.34 1.74e-10 Height; LUSC cis rs1371867 0.875 rs1660320 chr8:101337579 A/C cg06636551 chr8:101224915 SPAG1 -0.4 -7.41 -0.38 1.03e-12 Atrioventricular conduction; LUSC cis rs2290159 0.800 rs6766666 chr3:12690855 A/C cg23032965 chr3:12705835 RAF1 -0.71 -8.88 -0.44 4.28e-17 Cholesterol, total; LUSC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg21724239 chr8:58056113 NA 0.81 8.84 0.44 5.66e-17 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.51e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg13047869 chr3:10149882 C3orf24 0.61 8.04 0.4 1.61e-14 Alzheimer's disease; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg25243455 chr2:114033360 PAX8;LOC440839 0.34 7.81 0.39 7.67e-14 Lymphocyte counts; LUSC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.96 0.48 1.2e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9296092 0.500 rs9469504 chr6:33527243 G/A cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg09876464 chr15:85330779 ZNF592 0.36 6.39 0.33 5.58e-10 P wave terminal force; LUSC cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg23158103 chr7:148848205 ZNF398 -0.45 -7.25 -0.37 2.97e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8030485 0.730 rs57488047 chr15:79403002 T/C cg17916960 chr15:79447300 NA 0.34 6.12 0.32 2.67e-9 Left ventricle wall thickness; LUSC cis rs2073300 0.609 rs6137930 chr20:23376732 G/A cg12062639 chr20:23401060 NAPB 0.94 8.24 0.41 3.94e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9467773 0.935 rs1884947 chr6:26553273 G/T cg09904177 chr6:26538194 HMGN4 0.73 12.81 0.57 7.73e-31 Intelligence (multi-trait analysis); LUSC cis rs4746818 1.000 rs906217 chr10:70954661 T/C cg11621586 chr10:70884670 VPS26A 1.13 11.04 0.52 2.31e-24 Left atrial antero-posterior diameter; LUSC cis rs1322512 0.920 rs1407487 chr6:152945846 T/C cg27316956 chr6:152958899 SYNE1 -0.33 -5.65 -0.3 3.45e-8 Tonometry; LUSC cis rs360798 0.553 rs360804 chr2:62939397 C/T cg17519650 chr2:63277830 OTX1 -0.5 -7.21 -0.37 3.85e-12 Coronary artery disease; LUSC cis rs11031096 0.589 rs935130 chr11:4213530 A/G cg08557956 chr11:4115526 RRM1 -0.42 -5.72 -0.3 2.33e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11997175 0.624 rs7464055 chr8:33679382 G/A ch.8.33884649F chr8:33765107 NA 0.47 7.08 0.36 8.78e-12 Body mass index; LUSC cis rs28830936 0.934 rs4923915 chr15:42119606 C/T cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.78 -0.3 1.75e-8 Diastolic blood pressure; LUSC cis rs12950390 0.820 rs58391889 chr17:45865959 A/G cg03474202 chr17:45855739 NA -0.32 -7.23 -0.37 3.29e-12 IgG glycosylation; LUSC trans rs853679 0.517 rs9393898 chr6:28130376 G/T cg06606381 chr12:133084897 FBRSL1 -0.46 -6.26 -0.32 1.15e-9 Depression; LUSC cis rs61931739 0.534 rs1486886 chr12:34043619 C/T cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.05e-15 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg08888203 chr3:10149979 C3orf24 0.59 8.11 0.41 9.88e-15 Alzheimer's disease; LUSC cis rs721399 0.539 rs10087857 chr8:18267461 G/C cg18736775 chr8:18248649 NAT2 -0.59 -7.17 -0.37 4.78e-12 Blood metabolite levels; LUSC cis rs6754311 0.517 rs1469996 chr2:136542560 A/G cg07169764 chr2:136633963 MCM6 0.87 11.94 0.55 1.26e-27 Mosquito bite size; LUSC cis rs73195822 0.614 rs7309777 chr12:111213964 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 6.61 0.34 1.52e-10 Itch intensity from mosquito bite; LUSC cis rs727505 1.000 rs7790856 chr7:124459852 C/T cg23710748 chr7:124431027 NA -0.4 -7.26 -0.37 2.71e-12 Lewy body disease; LUSC cis rs6712932 0.925 rs10210149 chr2:105839324 C/T cg22878388 chr2:105853796 NA -0.33 -6.32 -0.33 8.39e-10 Type 2 diabetes; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg27284194 chr4:1044797 NA -0.36 -5.86 -0.31 1.09e-8 Obesity-related traits; LUSC cis rs9513627 1.000 rs7327068 chr13:100126965 A/G cg25919922 chr13:100150906 NA -0.74 -6.55 -0.34 2.2e-10 Obesity-related traits; LUSC cis rs7582180 0.591 rs1030902 chr2:101007178 T/G cg08017756 chr2:100939284 LONRF2 -0.44 -8.31 -0.41 2.51e-15 Intelligence (multi-trait analysis); LUSC cis rs7719624 0.870 rs10042825 chr5:135396084 A/T cg12897067 chr5:135418308 NA 0.4 5.68 0.3 2.91e-8 Response to cytidine analogues (gemcitabine); LUSC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg05472934 chr7:22766657 IL6 0.5 7.56 0.38 4e-13 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.62 -0.39 2.57e-13 Electroencephalogram traits; LUSC cis rs55665837 1.000 rs34382046 chr11:14451318 C/T cg05501817 chr11:14380813 RRAS2 -0.41 -6.53 -0.34 2.5e-10 Vitamin D levels; LUSC cis rs7760535 0.831 rs62420437 chr6:111748780 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.73 -0.35 7.4e-11 Metabolic traits; LUSC cis rs735539 0.636 rs9579928 chr13:21274807 C/G cg04906043 chr13:21280425 IL17D 0.38 6.44 0.33 4.27e-10 Dental caries; LUSC cis rs7408868 0.908 rs10416777 chr19:15276923 C/T cg14696996 chr19:15285081 NOTCH3 0.99 9.07 0.44 1.06e-17 Pulse pressure; LUSC cis rs273573 0.925 rs163882 chr11:30947681 C/G cg14844989 chr11:31128820 NA 0.38 6.0 0.31 5.07e-9 Total body bone mineral density; LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 12.06 0.55 4.64e-28 Prudent dietary pattern; LUSC cis rs4555082 0.957 rs2816609 chr14:105720803 A/C cg27165867 chr14:105738592 BRF1 -0.54 -7.63 -0.39 2.54e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg26441486 chr22:50317300 CRELD2 0.48 7.15 0.36 5.55e-12 Schizophrenia; LUSC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg19052272 chr2:3704530 ALLC -0.49 -8.19 -0.41 5.6e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg00784671 chr22:46762841 CELSR1 -0.55 -6.68 -0.34 1.01e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs77633900 0.614 rs2629025 chr15:76943363 G/C cg21673338 chr15:77095150 SCAPER -0.75 -7.56 -0.38 4e-13 Non-glioblastoma glioma;Glioma; LUSC cis rs2130392 0.926 rs7677893 chr4:185625523 T/C cg21366198 chr4:185655624 MLF1IP -0.44 -6.23 -0.32 1.38e-9 Kawasaki disease; LUSC cis rs7241530 0.662 rs2898715 chr18:75906351 T/C cg14642773 chr18:75888474 NA 0.39 5.99 0.31 5.45e-9 Educational attainment (years of education); LUSC cis rs7824557 0.767 rs7837036 chr8:11175489 A/G cg21775007 chr8:11205619 TDH 0.73 12.08 0.55 4.17e-28 Retinal vascular caliber; LUSC cis rs8017423 0.605 rs4904676 chr14:90819220 G/A cg04374321 chr14:90722782 PSMC1 -0.44 -6.64 -0.34 1.26e-10 Mortality in heart failure; LUSC cis rs6977660 0.714 rs10251774 chr7:19790489 T/C cg07541023 chr7:19748670 TWISTNB 0.67 7.16 0.36 5.25e-12 Thyroid stimulating hormone; LUSC cis rs7769051 0.522 rs56908272 chr6:133102165 G/C cg07930552 chr6:133119739 C6orf192 0.95 8.84 0.44 5.5e-17 Type 2 diabetes nephropathy; LUSC cis rs2227564 0.574 rs3849969 chr10:75525999 C/T cg23231163 chr10:75533350 FUT11 0.45 6.62 0.34 1.46e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02290803 chr1:40997356 ZNF684 -0.42 -6.07 -0.32 3.48e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4417855 0.665 rs57335767 chr3:187410979 A/G cg19198148 chr3:187451818 BCL6 0.57 10.26 0.49 1.2e-21 Granulocyte percentage of myeloid white cells; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.55 -9.13 -0.45 6.93e-18 Lymphocyte counts; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg16031515 chr1:205743344 RAB7L1 -0.29 -6.34 -0.33 7.64e-10 Menarche (age at onset); LUSC cis rs2404602 0.967 rs7174096 chr15:77072400 A/G cg26408565 chr15:76604113 ETFA -0.44 -6.91 -0.35 2.44e-11 Blood metabolite levels; LUSC trans rs7829975 0.606 rs10112585 chr8:8795030 A/T cg21775007 chr8:11205619 TDH -0.41 -6.24 -0.32 1.36e-9 Mood instability; LUSC cis rs611744 0.647 rs615233 chr8:109254262 C/T cg21045802 chr8:109455806 TTC35 0.43 6.6 0.34 1.58e-10 Dupuytren's disease; LUSC cis rs593982 1.000 rs650619 chr11:65506483 G/A cg08755490 chr11:65554678 OVOL1 1.41 17.33 0.69 1.95e-48 Atopic dermatitis; LUSC cis rs34638657 0.702 rs62044258 chr16:82199461 C/T cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.55e-10 Lung adenocarcinoma; LUSC cis rs7312933 0.703 rs7957471 chr12:42545591 G/T cg17420585 chr12:42539391 GXYLT1 -0.36 -6.84 -0.35 3.86e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs11871801 0.517 rs10454087 chr17:40735641 C/T cg16308533 chr17:40838983 CNTNAP1 0.4 5.86 0.31 1.13e-8 Crohn's disease; LUSC cis rs1908814 0.516 rs7825529 chr8:11794444 C/T cg21775007 chr8:11205619 TDH 0.47 6.72 0.34 8.1e-11 Neuroticism; LUSC trans rs208520 0.690 rs12208310 chr6:66730108 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.09 16.92 0.68 7.94e-47 Exhaled nitric oxide output; LUSC cis rs17253792 0.822 rs78143160 chr14:56150097 A/G cg01858014 chr14:56050164 KTN1 -0.81 -6.96 -0.36 1.84e-11 Putamen volume; LUSC cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.56e-13 Motion sickness; LUSC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.36 0.62 9.07e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg15445000 chr17:37608096 MED1 -0.38 -6.56 -0.34 2.06e-10 Glomerular filtration rate (creatinine); LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg00149659 chr3:10157352 C3orf10 1.01 14.91 0.63 6.88e-39 Alzheimer's disease; LUSC cis rs7572644 0.713 rs71441095 chr2:28089848 G/A cg27432699 chr2:27873401 GPN1 0.55 6.51 0.34 2.73e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs8058578 0.614 rs2878304 chr16:30878366 C/T cg02466173 chr16:30829666 NA 0.53 8.77 0.43 9.26e-17 Multiple myeloma; LUSC trans rs6952808 0.771 rs10244946 chr7:1921068 A/G cg04565464 chr8:145669602 NFKBIL2 -0.39 -6.57 -0.34 1.97e-10 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.77 -0.43 9.18e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7560272 0.512 rs12998980 chr2:73930726 A/C cg20560298 chr2:73613845 ALMS1 0.37 5.7 0.3 2.6e-8 Schizophrenia; LUSC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg20891283 chr12:69753455 YEATS4 0.6 8.25 0.41 3.66e-15 Response to diuretic therapy; LUSC cis rs7267979 0.966 rs6050532 chr20:25308793 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.57 -0.75 2.54e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg22467129 chr15:76604101 ETFA -0.46 -7.23 -0.37 3.22e-12 Blood metabolite levels; LUSC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg13877915 chr19:58951672 ZNF132 0.5 7.85 0.39 5.73e-14 Uric acid clearance; LUSC cis rs988712 0.662 rs11030100 chr11:27677586 G/T cg10635145 chr11:27742435 BDNF -0.46 -5.85 -0.3 1.16e-8 Obesity; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg12442385 chr7:1034912 NA -0.36 -6.26 -0.32 1.2e-9 Longevity;Endometriosis; LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg22963979 chr7:1858916 MAD1L1 -0.51 -7.7 -0.39 1.59e-13 Bipolar disorder and schizophrenia; LUSC cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg01884057 chr2:25150051 NA 0.48 11.26 0.52 3.64e-25 Body mass index; LUSC trans rs74417235 0.528 rs9324789 chr5:154074362 C/T cg13111374 chr4:17812581 NCAPG;DCAF16 -0.56 -6.07 -0.32 3.4e-9 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; LUSC cis rs2625529 0.824 rs4777471 chr15:72207804 A/G cg16672083 chr15:72433130 SENP8 -0.5 -7.35 -0.37 1.56e-12 Red blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00991755 chr18:46066406 KIAA0427 0.46 6.52 0.34 2.56e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg10556349 chr10:835070 NA 0.56 6.44 0.33 4.08e-10 Eosinophil percentage of granulocytes; LUSC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg04455712 chr21:45112962 RRP1B 0.46 8.56 0.42 4.25e-16 Mean corpuscular volume; LUSC cis rs6840360 0.615 rs113052419 chr4:152473008 T/C cg22705602 chr4:152727874 NA -0.32 -6.54 -0.34 2.33e-10 Intelligence (multi-trait analysis); LUSC cis rs929354 0.742 rs62491945 chr7:156955580 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.49 -0.46 4.49e-19 Body mass index; LUSC cis rs1215050 1.000 rs1215050 chr4:98849826 A/G cg05340658 chr4:99064831 C4orf37 -0.41 -6.21 -0.32 1.55e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4363385 0.747 rs4478766 chr1:152984906 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.88 -0.31 9.76e-9 Inflammatory skin disease; LUSC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg08219700 chr8:58056026 NA 0.45 5.84 0.3 1.24e-8 Developmental language disorder (linguistic errors); LUSC cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 8.62 0.43 2.81e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg04287289 chr16:89883240 FANCA 0.79 13.86 0.6 8.24e-35 Vitiligo; LUSC cis rs4789693 0.679 rs7213057 chr17:80378939 T/C cg04308225 chr17:80449738 NA 0.4 6.1 0.32 2.86e-9 Glucocorticoid-induced osteonecrosis; LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg14789911 chr21:47582049 C21orf56 0.42 6.61 0.34 1.54e-10 Testicular germ cell tumor; LUSC cis rs12618769 0.570 rs17444095 chr2:99075817 C/G cg10123293 chr2:99228465 UNC50 0.46 7.74 0.39 1.22e-13 Bipolar disorder; LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg25072359 chr17:41440525 NA 0.67 9.62 0.47 1.68e-19 Menopause (age at onset); LUSC cis rs193541 0.507 rs7726207 chr5:122081277 C/T cg19077854 chr5:122220652 SNX24 0.27 5.74 0.3 2.08e-8 Glucose homeostasis traits; LUSC cis rs62400317 0.762 rs1329711 chr6:44963401 A/G cg20913747 chr6:44695427 NA -0.45 -7.1 -0.36 7.62e-12 Total body bone mineral density; LUSC cis rs7267979 0.966 rs8123949 chr20:25388133 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.87 -0.74 1.57e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2688608 0.967 rs9971038 chr10:75661149 C/T cg23231163 chr10:75533350 FUT11 -0.37 -5.96 -0.31 6.29e-9 Inflammatory bowel disease; LUSC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg11608241 chr8:8085544 FLJ10661 -0.39 -6.01 -0.31 4.88e-9 Mood instability; LUSC trans rs961253 0.556 rs6054139 chr20:6327810 G/A cg21095983 chr6:86352623 SYNCRIP 0.45 6.78 0.35 5.62e-11 Colorectal cancer; LUSC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg18477163 chr1:228402036 OBSCN 0.62 12.19 0.55 1.61e-28 Diastolic blood pressure; LUSC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg04414720 chr1:150670196 GOLPH3L 0.52 8.1 0.41 1.06e-14 Melanoma; LUSC cis rs9393777 0.623 rs9358948 chr6:26483806 G/A cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC trans rs4927850 1.000 rs10881563 chr3:195750225 A/G cg21051086 chr3:73046214 PPP4R2 -0.53 -8.13 -0.41 8.54e-15 Pancreatic cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04512383 chr10:121631600 C10orf119 0.4 6.17 0.32 1.95e-9 Triglycerides; LUSC cis rs2985684 0.894 rs4581611 chr14:50043520 A/T cg04989706 chr14:50066350 PPIL5 -0.45 -5.79 -0.3 1.6e-8 Carotid intima media thickness; LUSC trans rs10514688 1.000 rs4678726 chr3:34976020 A/G cg12980127 chr5:2129874 NA -0.38 -5.94 -0.31 7.04e-9 Tonometry; LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC trans rs1325195 0.920 rs2816204 chr1:179164558 T/C cg11624085 chr17:8464688 MYH10 0.41 6.7 0.34 8.92e-11 IgE grass sensitization; LUSC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg25427524 chr10:38739819 LOC399744 -0.68 -12.51 -0.56 1.04e-29 Extrinsic epigenetic age acceleration; LUSC cis rs10266483 0.639 rs6952592 chr7:63754045 G/A cg24201672 chr7:64023550 ZNF680 -0.46 -5.94 -0.31 7.05e-9 Response to statin therapy; LUSC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg17143192 chr8:8559678 CLDN23 0.37 5.85 0.3 1.16e-8 Mood instability; LUSC trans rs4824093 0.610 rs4141437 chr22:50243719 C/G cg09872104 chr7:134855509 C7orf49 0.71 6.06 0.31 3.77e-9 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs11098499 0.697 rs6832410 chr4:120296800 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.21e-9 Corneal astigmatism; LUSC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg13175981 chr1:150552382 MCL1 0.48 6.76 0.35 6.01e-11 Lymphocyte counts; LUSC cis rs2948294 0.588 rs7011221 chr8:8114246 C/T cg15556689 chr8:8085844 FLJ10661 0.72 9.96 0.48 1.25e-20 Red cell distribution width; LUSC cis rs9486719 0.947 rs11153071 chr6:97039741 G/A cg06623918 chr6:96969491 KIAA0776 -0.84 -10.42 -0.5 3.25e-22 Migraine;Coronary artery disease; LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.75 0.35 6.67e-11 Menopause (age at onset); LUSC cis rs7267979 0.586 rs6083776 chr20:25186116 G/A cg08601574 chr20:25228251 PYGB 0.44 6.71 0.34 8.19e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1448094 0.933 rs11117102 chr12:86312720 A/C cg18827107 chr12:86230957 RASSF9 -0.43 -6.3 -0.33 9.25e-10 Major depressive disorder; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg01940439 chr12:132252573 SFRS8 -0.41 -6.51 -0.34 2.82e-10 N-glycan levels; LUSC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg00814883 chr7:100076585 TSC22D4 0.7 9.93 0.48 1.57e-20 Platelet count; LUSC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.69 -0.3 2.82e-8 Lung cancer; LUSC cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg04733989 chr22:42467013 NAGA -0.41 -6.66 -0.34 1.14e-10 Cognitive function; LUSC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.08 0.44 1e-17 Tonsillectomy; LUSC cis rs7582180 0.544 rs13026570 chr2:100939498 A/C cg14675211 chr2:100938903 LONRF2 0.38 5.96 0.31 6.44e-9 Intelligence (multi-trait analysis); LUSC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg25204440 chr1:209979598 IRF6 0.49 6.3 0.33 9.57e-10 Cleft lip with or without cleft palate; LUSC cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg19875535 chr5:140030758 IK -0.53 -8.93 -0.44 3.01e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs76878669 0.516 rs7104570 chr11:66159098 A/G cg18002602 chr11:66138449 SLC29A2 0.48 8.58 0.43 3.58e-16 Educational attainment (years of education); LUSC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.77 -12.4 -0.56 2.74e-29 Hip circumference adjusted for BMI; LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.48 6.58 0.34 1.82e-10 Renal function-related traits (BUN); LUSC trans rs561341 0.700 rs6505266 chr17:30225813 G/A cg20587970 chr11:113659929 NA -0.63 -8.81 -0.43 6.9e-17 Hip circumference adjusted for BMI; LUSC trans rs853679 0.517 rs9393897 chr6:28127710 G/T cg06606381 chr12:133084897 FBRSL1 -0.46 -6.19 -0.32 1.76e-9 Depression; LUSC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.39 -5.92 -0.31 7.93e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1348850 0.651 rs4893935 chr2:178240601 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 6.31 0.33 9.12e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4308124 0.708 rs10178095 chr2:111972516 C/T cg04571233 chr2:111982156 NA -0.52 -6.81 -0.35 4.45e-11 Vitiligo; LUSC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg16928487 chr17:17741425 SREBF1 0.45 8.92 0.44 3.14e-17 Total body bone mineral density; LUSC cis rs1801251 1.000 rs35085837 chr2:233624363 A/G cg08000102 chr2:233561755 GIGYF2 0.69 11.59 0.54 2.57e-26 Coronary artery disease; LUSC cis rs11098499 0.604 rs12642411 chr4:120580525 T/C cg24375607 chr4:120327624 NA 0.71 10.36 0.49 5.29e-22 Corneal astigmatism; LUSC cis rs4845570 1.000 rs11586946 chr1:151769806 G/A cg07092448 chr1:151763213 TDRKH -1.29 -14.75 -0.63 2.95e-38 Coronary artery disease; LUSC trans rs61931739 0.782 rs1197569 chr12:34186733 A/T cg24313572 chr1:56050060 NA -0.29 -5.95 -0.31 6.81e-9 Morning vs. evening chronotype; LUSC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC cis rs7267979 1.000 rs6115191 chr20:25440478 C/T cg03522245 chr20:25566470 NINL 0.35 5.66 0.3 3.26e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs17092148 1.000 rs2378260 chr20:33374897 G/A cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs9926296 0.609 rs4785714 chr16:89798404 G/T cg26513180 chr16:89883248 FANCA -0.55 -8.64 -0.43 2.44e-16 Vitiligo; LUSC cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg00033643 chr7:134001901 SLC35B4 -0.42 -6.43 -0.33 4.41e-10 Mean platelet volume; LUSC cis rs7727544 0.582 rs2301579 chr5:131553340 C/A cg24060327 chr5:131705240 SLC22A5 -0.34 -5.68 -0.3 3e-8 Blood metabolite levels; LUSC cis rs7560272 0.538 rs2421575 chr2:73919522 G/A cg20560298 chr2:73613845 ALMS1 0.38 5.81 0.3 1.5e-8 Schizophrenia; LUSC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.22 -0.32 1.49e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12681288 0.862 rs2004701 chr8:1022287 A/G cg04851639 chr8:1020857 NA -0.39 -8.1 -0.41 1.02e-14 Schizophrenia; LUSC cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.54 0.42 4.66e-16 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20102506 chr19:49621876 PPFIA3;C19orf73 0.43 6.45 0.33 3.98e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg23583168 chr7:148888333 NA -0.79 -12.58 -0.57 5.52e-30 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg07701084 chr6:150067640 NUP43 0.54 8.18 0.41 5.98e-15 Lung cancer; LUSC cis rs870825 0.616 rs28563856 chr4:185635581 G/A cg04058563 chr4:185651563 MLF1IP 0.88 13.13 0.58 4.9e-32 Blood protein levels; LUSC cis rs7568458 0.811 rs10175792 chr2:85761654 A/G cg17127132 chr2:85788382 GGCX 0.44 7.04 0.36 1.08e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg06238570 chr21:40685208 BRWD1 0.49 7.64 0.39 2.29e-13 Cognitive function; LUSC cis rs2456568 0.548 rs10765647 chr11:93662459 T/C cg17595323 chr11:93583763 C11orf90 -0.31 -5.78 -0.3 1.75e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21110739 chr6:160768369 SLC22A3 -0.4 -5.95 -0.31 6.79e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs61931739 0.963 rs3912355 chr12:34079616 A/G cg26384229 chr12:38710491 ALG10B 0.51 7.66 0.39 2.02e-13 Morning vs. evening chronotype; LUSC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.49 5.89 0.31 9.59e-9 Renal function-related traits (BUN); LUSC cis rs61629263 0.531 rs11867362 chr17:41938082 A/T cg26893861 chr17:41843967 DUSP3 -0.47 -5.79 -0.3 1.62e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs2710642 0.821 rs56373728 chr2:63095792 G/A cg17519650 chr2:63277830 OTX1 0.51 7.09 0.36 8.28e-12 LDL cholesterol levels;LDL cholesterol; LUSC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg02773041 chr1:40204384 PPIE 0.53 7.86 0.4 5.41e-14 Blood protein levels; LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.15 0.36 5.62e-12 Bipolar disorder; LUSC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg06454157 chr6:167490870 NA -0.26 -6.19 -0.32 1.75e-9 Crohn's disease; LUSC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg02423579 chr7:2872169 GNA12 -0.46 -6.61 -0.34 1.55e-10 Height; LUSC cis rs9788682 0.747 rs2869045 chr15:78718899 T/C cg06917634 chr15:78832804 PSMA4 0.48 5.7 0.3 2.58e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01002995 chr12:8185077 FOXJ2 -0.4 -6.0 -0.31 5.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg22823121 chr1:150693482 HORMAD1 -0.45 -6.75 -0.35 6.42e-11 Tonsillectomy; LUSC cis rs9457247 0.602 rs9457262 chr6:167473685 A/G cg06454157 chr6:167490870 NA -0.29 -6.78 -0.35 5.52e-11 Crohn's disease; LUSC cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.51 -0.34 2.79e-10 Menopause (age at onset); LUSC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg24060327 chr5:131705240 SLC22A5 -0.51 -8.47 -0.42 7.99e-16 Breast cancer; LUSC cis rs1982963 0.627 rs77101097 chr14:52494300 C/T cg10843707 chr14:52510701 NID2 0.47 6.4 0.33 5.16e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg08069147 chr6:88032118 GJB7;C6orf162 0.71 10.86 0.51 1.03e-23 Monocyte percentage of white cells; LUSC cis rs7923609 0.846 rs10740116 chr10:65094992 T/C cg01631684 chr10:65280961 REEP3 -0.41 -6.43 -0.33 4.53e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs4400599 0.606 rs7542975 chr1:154204813 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.02 -0.31 4.47e-9 Platelet distribution width; LUSC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg06718696 chr17:78121285 EIF4A3 0.78 11.49 0.53 5.84e-26 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg19046167 chr17:80928561 B3GNTL1 0.41 5.8 0.3 1.5e-8 Breast cancer; LUSC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg19592336 chr6:28129416 ZNF389 0.51 6.58 0.34 1.8e-10 Depression; LUSC trans rs10435719 0.780 rs9692662 chr8:11789863 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.09 0.4 1.12e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9341808 0.650 rs6909546 chr6:80869923 C/G cg08355045 chr6:80787529 NA 0.57 9.9 0.48 1.97e-20 Sitting height ratio; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg17294928 chr15:75287854 SCAMP5 0.41 5.88 0.31 1e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs7592578 0.882 rs7569128 chr2:191446691 C/A cg11845111 chr2:191398756 TMEM194B 0.85 11.27 0.52 3.56e-25 Diastolic blood pressure; LUSC cis rs9640161 0.830 rs1051823 chr7:150070814 G/A cg21361702 chr7:150065534 REPIN1 0.59 9.17 0.45 4.8e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs6500395 0.963 rs961951 chr16:48716720 A/G cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC trans rs11098499 0.954 rs17005535 chr4:120411562 C/T cg25214090 chr10:38739885 LOC399744 0.54 7.96 0.4 2.77e-14 Corneal astigmatism; LUSC cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs2985684 0.901 rs57119148 chr14:50097226 T/C cg04989706 chr14:50066350 PPIL5 -0.43 -5.66 -0.3 3.24e-8 Carotid intima media thickness; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg14159672 chr1:205819179 PM20D1 -0.41 -5.96 -0.31 6.41e-9 Menarche (age at onset); LUSC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg08219700 chr8:58056026 NA 0.48 6.15 0.32 2.21e-9 Developmental language disorder (linguistic errors); LUSC cis rs4851254 0.660 rs1821830 chr2:100680279 C/T cg07810366 chr2:100720526 AFF3 -0.47 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.967 rs9295694 chr6:26512994 A/T cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.52e-42 Intelligence (multi-trait analysis); LUSC cis rs1395 1.000 rs1275537 chr2:27441302 C/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 6.99 0.36 1.46e-11 Blood metabolite levels; LUSC cis rs4474465 0.790 rs10751293 chr11:78250956 A/T cg27205649 chr11:78285834 NARS2 0.5 6.03 0.31 4.3e-9 Alzheimer's disease (survival time); LUSC cis rs922692 0.744 rs11639044 chr15:79083814 C/T cg00540400 chr15:79124168 NA -0.44 -7.67 -0.39 1.88e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs62400317 0.859 rs12205523 chr6:45296618 T/C cg20913747 chr6:44695427 NA -0.47 -7.72 -0.39 1.35e-13 Total body bone mineral density; LUSC trans rs61931739 0.500 rs11053212 chr12:34466116 T/G cg26384229 chr12:38710491 ALG10B 0.9 15.73 0.65 4.14e-42 Morning vs. evening chronotype; LUSC cis rs9303401 0.555 rs8073699 chr17:57236317 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.5 7.66 0.39 2.06e-13 Cognitive test performance; LUSC cis rs500891 0.525 rs750384 chr6:84030422 C/T cg08257003 chr6:84140564 ME1 0.34 8.05 0.4 1.43e-14 Platelet-derived growth factor BB levels; LUSC cis rs6087771 0.642 rs6060411 chr20:30222139 T/C cg13852791 chr20:30311386 BCL2L1 0.82 10.75 0.51 2.37e-23 Subcortical brain region volumes;Putamen volume; LUSC cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg17042849 chr6:26104293 HIST1H4C -0.38 -5.66 -0.3 3.3e-8 Height; LUSC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg17971929 chr21:40555470 PSMG1 -0.5 -7.49 -0.38 6.2800000000000005e-13 Menarche (age at onset); LUSC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg04414720 chr1:150670196 GOLPH3L -0.5 -8.15 -0.41 7.48e-15 Tonsillectomy; LUSC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg18451016 chr1:38461880 NA -0.49 -7.28 -0.37 2.37e-12 Coronary artery disease; LUSC cis rs6088590 1.000 rs11696546 chr20:33452999 C/G cg24642439 chr20:33292090 TP53INP2 0.71 11.2 0.52 6e-25 Coronary artery disease; LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.55 -8.64 -0.43 2.32e-16 Prudent dietary pattern; LUSC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg21918786 chr6:109611834 NA 0.42 7.35 0.37 1.55e-12 Reticulocyte fraction of red cells; LUSC cis rs2354432 0.599 rs6693667 chr1:146817245 A/T cg25205988 chr1:146714368 CHD1L 0.9 9.37 0.46 1.15e-18 Mitochondrial DNA levels; LUSC cis rs6500395 0.926 rs8057777 chr16:48565643 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.52 0.34 2.66e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg19680485 chr15:31195859 MTMR15 0.5 6.55 0.34 2.23e-10 Huntington's disease progression; LUSC cis rs7617773 0.779 rs1045482 chr3:48312229 A/G cg11946769 chr3:48343235 NME6 0.75 11.45 0.53 7.65e-26 Coronary artery disease; LUSC cis rs12681288 0.550 rs12549204 chr8:959085 G/T cg15309053 chr8:964076 NA 0.43 8.82 0.43 6.26e-17 Schizophrenia; LUSC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg11663144 chr21:46675770 NA -0.41 -7.06 -0.36 9.82e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg21573476 chr21:45109991 RRP1B -0.39 -6.32 -0.33 8.38e-10 Mean corpuscular volume; LUSC cis rs6693567 0.565 rs834238 chr1:150366469 G/T cg09579323 chr1:150459698 TARS2 0.4 5.68 0.3 2.99e-8 Migraine; LUSC cis rs2219968 1.000 rs12679679 chr8:78974231 T/C cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.62 13.01 0.58 1.41e-31 Monocyte percentage of white cells; LUSC cis rs7589342 0.862 rs10469862 chr2:106509907 C/T cg16077055 chr2:106428750 NCK2 0.33 6.15 0.32 2.19e-9 Addiction; LUSC cis rs7829975 0.572 rs28730413 chr8:8795447 A/C cg06636001 chr8:8085503 FLJ10661 -0.51 -8.19 -0.41 5.62e-15 Mood instability; LUSC cis rs240764 0.853 rs1875400 chr6:101020968 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.19 -0.32 1.8e-9 Neuroticism; LUSC cis rs1153858 0.621 rs2687512 chr15:45581495 T/C cg14582100 chr15:45693742 SPATA5L1 -0.53 -9.05 -0.44 1.19e-17 Homoarginine levels; LUSC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg16606324 chr3:10149918 C3orf24 0.43 6.48 0.33 3.24e-10 Alzheimer's disease; LUSC cis rs5753037 0.702 rs140101 chr22:30128380 C/T cg11564601 chr22:30592435 NA 0.33 6.06 0.31 3.71e-9 Type 1 diabetes; LUSC cis rs7582180 0.627 rs4407265 chr2:101005846 C/G cg12002119 chr2:101014098 CHST10 0.37 6.19 0.32 1.72e-9 Intelligence (multi-trait analysis); LUSC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg17507749 chr15:85114479 UBE2QP1 0.67 8.72 0.43 1.32e-16 Schizophrenia; LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg27284194 chr4:1044797 NA 0.36 5.83 0.3 1.28e-8 Obesity-related traits; LUSC cis rs826838 1.000 rs826889 chr12:39101076 G/A cg13010199 chr12:38710504 ALG10B -0.65 -11.12 -0.52 1.19e-24 Heart rate; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -6.11 -0.32 2.84e-9 Developmental language disorder (linguistic errors); LUSC cis rs950169 0.845 rs4106951 chr15:84833394 C/G cg12863693 chr15:85201151 NMB 0.35 7.24 0.37 3.1e-12 Schizophrenia; LUSC cis rs5167 0.533 rs11083755 chr19:45490065 C/T cg13119609 chr19:45449297 APOC2 0.34 5.67 0.3 3.01e-8 Blood protein levels; LUSC cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.61 8.35 0.42 1.8e-15 Body mass index (adult); LUSC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg04398451 chr17:18023971 MYO15A -0.48 -7.72 -0.39 1.34e-13 Total body bone mineral density; LUSC cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg08601574 chr20:25228251 PYGB 0.44 6.75 0.35 6.5e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9326248 1.000 rs7946257 chr11:117053165 A/G cg01368799 chr11:117014884 PAFAH1B2 0.52 6.91 0.35 2.44e-11 Blood protein levels; LUSC cis rs559928 0.606 rs55970968 chr11:63961433 C/T cg24687543 chr11:63912206 MACROD1 0.46 5.84 0.3 1.21e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg03264133 chr6:25882463 NA -0.5 -9.15 -0.45 5.74e-18 Blood metabolite levels; LUSC cis rs1042058 0.565 rs2480297 chr10:30754512 A/G cg25182066 chr10:30743637 MAP3K8 -0.44 -6.61 -0.34 1.55e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs12681287 0.640 rs6992287 chr8:87418960 G/A cg27223183 chr8:87520930 FAM82B 0.55 7.52 0.38 4.95e-13 Caudate activity during reward; LUSC cis rs4363385 0.747 rs9919333 chr1:152968744 G/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.74 -0.39 1.21e-13 Inflammatory skin disease; LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03352830 chr11:487213 PTDSS2 0.73 8.44 0.42 9.94e-16 Body mass index; LUSC cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg27446573 chr6:127587934 RNF146 0.6 9.1 0.45 8.47e-18 Breast cancer; LUSC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg25258033 chr6:167368657 RNASET2 -0.47 -7.88 -0.4 4.79e-14 Crohn's disease; LUSC cis rs2282802 0.685 rs13359519 chr5:139654664 G/A cg26211634 chr5:139558579 C5orf32 0.44 8.34 0.42 1.95e-15 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg13683864 chr3:40499215 RPL14 -1.15 -20.58 -0.75 2.36e-61 Renal cell carcinoma; LUSC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11890956 chr21:40555474 PSMG1 -0.91 -16.56 -0.67 2.1e-45 Cognitive function; LUSC trans rs9944715 0.954 rs7240354 chr18:43809614 G/A cg01718231 chr17:29326311 RNF135 -0.5 -7.03 -0.36 1.15e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs73198271 0.813 rs56007835 chr8:8610026 G/A cg15556689 chr8:8085844 FLJ10661 -0.53 -6.74 -0.35 6.92e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg27535305 chr1:53392650 SCP2 -0.48 -9.51 -0.46 3.88e-19 Monocyte count; LUSC cis rs68170813 0.559 rs12536574 chr7:106810997 A/T cg02696742 chr7:106810147 HBP1 -0.63 -9.28 -0.45 2.15e-18 Coronary artery disease; LUSC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.73 0.35 7.36e-11 Lung cancer; LUSC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg14552801 chr7:65878734 NA -0.38 -5.9 -0.31 8.98e-9 Aortic root size; LUSC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg23625390 chr15:77176239 SCAPER 0.5 7.77 0.39 9.94e-14 Blood metabolite levels; LUSC cis rs1018836 0.886 rs7817954 chr8:91535105 G/A cg16814680 chr8:91681699 NA -0.77 -12.89 -0.58 3.84e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4319547 0.656 rs10773075 chr12:122814236 G/A cg23029597 chr12:123009494 RSRC2 -0.75 -9.46 -0.46 5.71e-19 Body mass index; LUSC cis rs1045714 0.895 rs4719594 chr7:2639790 G/A cg24848437 chr7:2645542 IQCE 0.61 6.71 0.34 8.34e-11 Urate levels in lean individuals; LUSC cis rs1832871 0.711 rs12527510 chr6:158657299 T/G cg07165851 chr6:158734300 TULP4 0.51 7.61 0.38 2.86e-13 Height; LUSC cis rs644799 0.544 rs525087 chr11:95632266 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.57 8.54 0.42 4.96e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4595586 0.525 rs73096109 chr12:39355720 C/A cg26384229 chr12:38710491 ALG10B 0.54 7.65 0.39 2.19e-13 Morning vs. evening chronotype; LUSC cis rs7100689 0.646 rs4265545 chr10:82119271 G/T cg00277334 chr10:82204260 NA -0.54 -7.92 -0.4 3.59e-14 Post bronchodilator FEV1; LUSC cis rs1790761 0.505 rs17593068 chr11:67350932 G/T cg24690094 chr11:67383802 NA -0.3 -5.75 -0.3 1.98e-8 Mean corpuscular volume; LUSC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.52 -0.53 4.54e-26 Schizophrenia; LUSC trans rs6598955 0.671 rs57386998 chr1:26569821 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs10464366 0.560 rs12701692 chr7:39135551 A/G cg18850127 chr7:39170497 POU6F2 0.58 9.12 0.45 7.12e-18 IgG glycosylation; LUSC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg14196790 chr5:131705035 SLC22A5 -0.42 -6.78 -0.35 5.61e-11 Breast cancer;Mosquito bite size; LUSC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 7.93 0.4 3.42e-14 Schizophrenia; LUSC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg13206674 chr6:150067644 NUP43 0.55 8.11 0.41 9.51e-15 Lung cancer; LUSC cis rs134594 0.569 rs134559 chr22:29458441 C/T cg03665785 chr22:29458676 C22orf31 -0.38 -7.29 -0.37 2.21e-12 Birth weight; LUSC cis rs1953600 0.818 rs2152546 chr10:81906384 G/T cg04850286 chr10:81895943 PLAC9 -0.39 -6.78 -0.35 5.35e-11 Sarcoidosis; LUSC cis rs11098499 0.754 rs1980027 chr4:120251577 C/T cg24375607 chr4:120327624 NA 0.76 12.09 0.55 3.55e-28 Corneal astigmatism; LUSC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg10909506 chr17:38081995 ORMDL3 0.32 5.75 0.3 2.06e-8 Self-reported allergy; LUSC cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg00074818 chr8:8560427 CLDN23 0.59 9.92 0.48 1.71e-20 Obesity-related traits; LUSC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg18904891 chr8:8559673 CLDN23 0.58 7.93 0.4 3.29e-14 Obesity-related traits; LUSC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.5 0.42 6.19e-16 Prudent dietary pattern; LUSC cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg23583168 chr7:148888333 NA -0.82 -12.73 -0.57 1.58e-30 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg23283495 chr1:209979779 IRF6 0.64 9.36 0.46 1.21e-18 Cleft lip with or without cleft palate; LUSC cis rs10865541 0.778 rs10779975 chr2:3420032 A/G cg15807143 chr2:3452624 TTC15 0.32 5.67 0.3 3.09e-8 Obesity-related traits; LUSC cis rs2880765 0.566 rs17553249 chr15:86006694 A/G cg10818794 chr15:86012489 AKAP13 -0.43 -6.84 -0.35 3.87e-11 Coronary artery disease; LUSC cis rs2274273 0.840 rs66486619 chr14:55869555 T/G cg04306507 chr14:55594613 LGALS3 0.55 12.42 0.56 2.26e-29 Protein biomarker; LUSC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg05585544 chr11:47624801 NA -0.42 -7.29 -0.37 2.21e-12 Subjective well-being; LUSC cis rs62400317 0.859 rs17209678 chr6:45163601 C/T cg20913747 chr6:44695427 NA -0.48 -7.7 -0.39 1.56e-13 Total body bone mineral density; LUSC cis rs12304921 0.639 rs7722 chr12:51455404 C/A cg02675652 chr12:51477739 CSRNP2 -0.28 -5.8 -0.3 1.57e-8 Type 2 diabetes; LUSC cis rs3784262 1.000 rs4646627 chr15:58255305 A/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.8 -0.3 1.51e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7560272 0.723 rs7566315 chr2:73791808 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -7.4 -0.38 1.11e-12 Schizophrenia; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg11494091 chr17:61959527 GH2 0.64 13.71 0.6 2.91e-34 Prudent dietary pattern; LUSC cis rs36093844 0.898 rs12361645 chr11:85595106 C/G cg16165120 chr11:85566439 CCDC83 -0.37 -6.07 -0.32 3.51e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.77 -0.35 5.76e-11 Monocyte percentage of white cells; LUSC trans rs9329221 0.597 rs17751178 chr8:10116730 A/G cg06636001 chr8:8085503 FLJ10661 0.46 6.44 0.33 4.13e-10 Neuroticism; LUSC cis rs4711336 1.000 rs4711336 chr6:33659046 A/G cg15676125 chr6:33679581 C6orf125 -0.38 -5.69 -0.3 2.76e-8 Height; LUSC trans rs2018683 0.932 rs4386882 chr7:28989270 C/T cg19402173 chr7:128379420 CALU -0.56 -8.79 -0.43 7.95e-17 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs4588572 0.643 rs9293747 chr5:77705567 A/G cg11547950 chr5:77652471 NA -0.52 -7.62 -0.38 2.7e-13 Triglycerides; LUSC cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg24296786 chr1:45957014 TESK2 -0.48 -6.91 -0.35 2.41e-11 High light scatter reticulocyte count; LUSC cis rs6542838 0.641 rs6724477 chr2:99537074 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 0.54 7.26 0.37 2.69e-12 Fear of minor pain; LUSC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.75 -13.05 -0.58 9.4e-32 Total body bone mineral density; LUSC cis rs11098499 0.954 rs17009122 chr4:120362403 G/A cg09307838 chr4:120376055 NA 0.78 11.23 0.52 4.88e-25 Corneal astigmatism; LUSC cis rs559928 0.556 rs734762 chr11:63912189 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.19 0.37 4.21e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg06671706 chr8:8559999 CLDN23 0.51 6.84 0.35 3.84e-11 Obesity-related traits; LUSC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg03060546 chr3:49711283 APEH 0.48 6.42 0.33 4.68e-10 Menarche (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05889321 chr10:97416837 ALDH18A1 0.4 6.12 0.32 2.68e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg06462663 chr19:18546047 ISYNA1 0.46 7.47 0.38 6.86e-13 Breast cancer; LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 9.55 0.46 2.93e-19 Mean platelet volume; LUSC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4969178 0.965 rs4969186 chr17:76398404 C/G cg20026190 chr17:76395443 PGS1 0.46 8.07 0.4 1.28e-14 HDL cholesterol levels; LUSC cis rs11122272 0.735 rs2486733 chr1:231531465 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.25 -0.49 1.32e-21 Hemoglobin concentration; LUSC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg21724239 chr8:58056113 NA 0.78 8.41 0.42 1.19e-15 Developmental language disorder (linguistic errors); LUSC trans rs2243480 1.000 rs4149468 chr7:65825690 T/C cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg08807101 chr21:30365312 RNF160 0.81 15.35 0.64 1.32e-40 Dental caries; LUSC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg04871131 chr7:94954202 PON1 -0.39 -6.13 -0.32 2.44e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7267979 1.000 rs3002702 chr20:25268920 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.46 0.75 6.72e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg21724239 chr8:58056113 NA 0.85 8.52 0.42 5.67e-16 Developmental language disorder (linguistic errors); LUSC cis rs782590 0.620 rs4322879 chr2:55797033 G/T cg03859395 chr2:55845619 SMEK2 -0.71 -10.56 -0.5 1.11e-22 Metabolic syndrome; LUSC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg14004847 chr7:1930337 MAD1L1 0.55 8.52 0.42 5.39e-16 Bipolar disorder and schizophrenia; LUSC trans rs853679 0.607 rs34950484 chr6:28278688 G/A cg01620082 chr3:125678407 NA -0.79 -7.53 -0.38 4.89e-13 Depression; LUSC cis rs735396 0.770 rs2264782 chr12:121432603 C/T cg02403541 chr12:121454288 C12orf43 0.61 8.57 0.42 3.77e-16 N-glycan levels; LUSC cis rs11098499 0.954 rs6847248 chr4:120225955 A/G cg24375607 chr4:120327624 NA 0.8 11.48 0.53 6.06e-26 Corneal astigmatism; LUSC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg15445000 chr17:37608096 MED1 0.37 6.41 0.33 4.95e-10 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg05347473 chr6:146136440 FBXO30 0.5 8.36 0.42 1.67e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg00033643 chr7:134001901 SLC35B4 0.46 7.1 0.36 7.56e-12 Mean platelet volume; LUSC cis rs6500395 1.000 rs8052640 chr16:48604096 G/T cg04672837 chr16:48644449 N4BP1 0.46 6.87 0.35 3.19e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.19e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg14298792 chr15:30685198 CHRFAM7A -0.69 -8.81 -0.43 7.17e-17 Huntington's disease progression; LUSC trans rs9951602 0.512 rs4798995 chr18:76654344 T/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.48 7.14 0.36 5.88e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9560113 0.959 rs9560108 chr13:112180303 A/C cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.54e-13 Menarche (age at onset); LUSC cis rs11711311 0.747 rs9882193 chr3:113349451 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.44 -5.97 -0.31 6.09e-9 IgG glycosylation; LUSC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg01765077 chr12:122356316 WDR66 0.57 8.01 0.4 1.94e-14 Mean corpuscular volume; LUSC cis rs11190604 0.767 rs7078070 chr10:102166415 A/C cg07080220 chr10:102295463 HIF1AN 0.59 7.68 0.39 1.83e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs735539 0.598 rs2149769 chr13:21266227 C/T cg04906043 chr13:21280425 IL17D 0.4 6.7 0.34 8.64e-11 Dental caries; LUSC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.86 -0.31 1.13e-8 Alzheimer's disease (late onset); LUSC cis rs1395 0.744 rs11126934 chr2:27476613 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.57 0.38 3.75e-13 Blood metabolite levels; LUSC cis rs2625529 0.730 rs2957737 chr15:72265410 A/G cg16672083 chr15:72433130 SENP8 0.48 7.7 0.39 1.6e-13 Red blood cell count; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg11494091 chr17:61959527 GH2 0.64 13.54 0.6 1.4e-33 Prudent dietary pattern; LUSC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg13175981 chr1:150552382 MCL1 -0.49 -6.44 -0.33 4.2e-10 Urate levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09342330 chr14:89021109 PTPN21 -0.51 -6.27 -0.32 1.13e-9 Bipolar disorder and schizophrenia; LUSC cis rs3087591 1.000 rs2905877 chr17:29543269 A/C cg24425628 chr17:29625626 OMG;NF1 -0.57 -8.35 -0.42 1.79e-15 Hip circumference; LUSC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg27165867 chr14:105738592 BRF1 -0.5 -7.08 -0.36 8.75e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg03676636 chr4:99064102 C4orf37 0.32 6.53 0.34 2.45e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.45 0.33 3.98e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9807989 0.729 rs10170583 chr2:102974764 G/A cg09003973 chr2:102972529 NA 0.44 5.98 0.31 5.64e-9 Asthma; LUSC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg00484396 chr16:3507460 NAT15 0.49 7.18 0.37 4.59e-12 Body mass index (adult); LUSC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg00033643 chr7:134001901 SLC35B4 -0.44 -6.75 -0.35 6.72e-11 Mean platelet volume; LUSC trans rs11098499 0.604 rs2389882 chr4:120566733 A/C cg25214090 chr10:38739885 LOC399744 0.48 6.98 0.36 1.59e-11 Corneal astigmatism; LUSC cis rs12291225 0.546 rs12291662 chr11:14342949 T/C cg05501817 chr11:14380813 RRAS2 -0.56 -9.31 -0.45 1.74e-18 Sense of smell; LUSC cis rs11264799 0.603 rs2224607 chr1:157571721 C/T cg18268488 chr1:157545234 FCRL4 0.35 6.28 0.33 1.04e-9 IgA nephropathy; LUSC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg11366901 chr6:160182831 ACAT2 0.91 12.24 0.56 1.04e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs765787 0.530 rs2554456 chr15:45521138 A/C cg24006582 chr15:45444508 DUOX1 -0.61 -8.96 -0.44 2.4e-17 Uric acid levels; LUSC cis rs12541635 0.639 rs10955408 chr8:107020789 G/A cg10147462 chr8:107024639 NA 0.68 14.26 0.62 2.2e-36 Age of smoking initiation; LUSC cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Bladder cancer; LUSC cis rs34779708 0.966 rs4934735 chr10:35496730 C/T cg03585969 chr10:35415529 CREM -0.62 -9.18 -0.45 4.52e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7523050 0.908 rs17621644 chr1:109399023 C/T cg08274380 chr1:109419600 GPSM2 0.92 9.73 0.47 7.24e-20 Fat distribution (HIV); LUSC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg08847533 chr14:75593920 NEK9 -0.82 -14.8 -0.63 1.89e-38 Height; LUSC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg09034736 chr1:150693464 HORMAD1 0.41 5.67 0.3 3.05e-8 Melanoma; LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.5 0.34 2.95e-10 Electroencephalogram traits; LUSC cis rs7296418 0.630 rs11057238 chr12:123767971 C/A cg13010344 chr12:123464640 ARL6IP4 -0.49 -7.95 -0.4 2.86e-14 Platelet count; LUSC cis rs11971779 0.715 rs10085527 chr7:139064360 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs5009270 0.553 rs62476688 chr7:112232716 C/T cg27282281 chr7:112262583 NA 0.43 5.8 0.3 1.57e-8 Osteoarthritis (hip); LUSC cis rs12421382 0.507 rs11600810 chr11:109356443 G/A cg11473876 chr11:109292803 C11orf87 0.42 6.53 0.34 2.51e-10 Schizophrenia; LUSC cis rs7927592 0.513 rs607887 chr11:68196961 C/T cg01657329 chr11:68192670 LRP5 -0.49 -7.65 -0.39 2.18e-13 Total body bone mineral density; LUSC cis rs11229555 0.645 rs11560908 chr11:58434545 A/C cg15696309 chr11:58395628 NA 0.62 6.66 0.34 1.14e-10 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4727027 0.704 rs4727031 chr7:148908305 T/C cg23583168 chr7:148888333 NA -0.89 -17.11 -0.68 1.39e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12586317 0.620 rs17103042 chr14:35575428 T/C cg05294307 chr14:35346193 BAZ1A -0.57 -7.05 -0.36 1.01e-11 Psoriasis; LUSC cis rs4664304 0.772 rs10183731 chr2:160740989 A/G cg23995753 chr2:160760732 LY75 0.33 6.15 0.32 2.23e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg07777115 chr5:623756 CEP72 -0.47 -5.77 -0.3 1.78e-8 Lung disease severity in cystic fibrosis; LUSC cis rs12421382 0.615 rs11607972 chr11:109392155 A/G cg27471124 chr11:109292789 C11orf87 0.43 7.46 0.38 7.48e-13 Schizophrenia; LUSC cis rs3862030 0.720 rs1056744 chr10:104236687 A/G cg05855489 chr10:104503620 C10orf26 0.5 7.68 0.39 1.8e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs10740039 0.883 rs10761533 chr10:62398331 G/C cg18175470 chr10:62150864 ANK3 -0.46 -6.85 -0.35 3.59e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.73 -0.6 2.62e-34 Chronic sinus infection; LUSC cis rs151234 0.565 rs11401 chr16:28602991 A/G cg01378222 chr16:28622494 SULT1A1 -0.55 -8.07 -0.4 1.31e-14 Platelet distribution width; LUSC cis rs9790314 1.000 rs7638668 chr3:161047283 G/A cg03342759 chr3:160939853 NMD3 -0.49 -8.18 -0.41 5.82e-15 Morning vs. evening chronotype; LUSC cis rs12579753 0.830 rs12825476 chr12:82238350 G/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs3008870 0.755 rs6657065 chr1:67384639 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.5 0.56 1.09e-29 Lymphocyte percentage of white cells; LUSC cis rs868036 1.000 rs1026734 chr15:68100950 T/C cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs10144321 0.729 rs10438233 chr14:100826200 C/T cg14882082 chr14:100845427 WDR25 -0.39 -7.53 -0.38 4.86e-13 Menarche (age at onset); LUSC cis rs6539267 0.885 rs34762209 chr12:106722466 T/C cg00173435 chr12:106696525 TCP11L2 0.5 6.77 0.35 5.92e-11 Tourette syndrome; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg10150615 chr22:24372951 LOC391322 -0.42 -6.86 -0.35 3.4e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11098499 0.863 rs2291185 chr4:120434833 C/A cg25214090 chr10:38739885 LOC399744 0.5 7.45 0.38 8.19e-13 Corneal astigmatism; LUSC cis rs13217239 0.646 rs4269366 chr6:27016413 C/T cg05738196 chr6:26577821 NA 0.54 8.49 0.42 6.82e-16 Schizophrenia; LUSC cis rs68170813 0.559 rs7794965 chr7:106826439 A/G cg02696742 chr7:106810147 HBP1 0.64 9.78 0.47 5.05e-20 Coronary artery disease; LUSC cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg22676075 chr6:135203613 NA 0.59 9.48 0.46 5e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg23815491 chr16:72088622 HP 0.37 6.57 0.34 1.9e-10 Fibrinogen levels; LUSC cis rs500891 0.525 rs3778201 chr6:84081405 C/T cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg10820045 chr2:198174542 NA -0.33 -6.1 -0.32 2.9e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg10253484 chr15:75165896 SCAMP2 -0.49 -7.51 -0.38 5.46e-13 Breast cancer; LUSC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg23887609 chr12:130822674 PIWIL1 0.48 7.05 0.36 1.04e-11 Menopause (age at onset); LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg17541715 chr7:1216824 NA -0.4 -6.12 -0.32 2.57e-9 Longevity;Endometriosis; LUSC trans rs3733585 0.648 rs7376155 chr4:9952588 C/T cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.13e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05788437 chr3:197476880 FYTTD1;KIAA0226 -0.33 -5.97 -0.31 6.22e-9 Electrocardiographic conduction measures; LUSC cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg18252515 chr7:66147081 NA -1.21 -13.88 -0.6 6.79e-35 Diabetic kidney disease; LUSC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11644478 chr21:40555479 PSMG1 0.92 17.26 0.69 3.59e-48 Cognitive function; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg08922808 chr11:47448170 PSMC3 0.72 6.06 0.31 3.57e-9 Body mass index; LUSC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09961100 chr19:5978428 RANBP3 -0.41 -6.08 -0.32 3.32e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504073 0.669 rs341809 chr8:50042557 C/T cg00325661 chr8:49890786 NA 0.6 9.65 0.47 1.32e-19 Blood metabolite ratios; LUSC cis rs10193935 0.901 rs10174872 chr2:42459807 T/G cg27598129 chr2:42591480 NA -0.61 -8.32 -0.41 2.28e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg13175981 chr1:150552382 MCL1 0.52 7.38 0.37 1.24e-12 Tonsillectomy; LUSC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg04155289 chr7:94953770 PON1 0.34 5.78 0.3 1.68e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs977987 0.771 rs4888387 chr16:75389755 T/G cg04384234 chr16:75411784 CFDP1 -0.39 -6.24 -0.32 1.34e-9 Dupuytren's disease; LUSC cis rs7804356 1.000 rs2031811 chr7:26890672 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg21724239 chr8:58056113 NA 0.8 8.44 0.42 9.52e-16 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg26338869 chr17:61819248 STRADA 0.42 6.06 0.31 3.7e-9 Prudent dietary pattern; LUSC cis rs9650657 0.504 rs2409724 chr8:11041642 A/T cg27411982 chr8:10470053 RP1L1 -0.39 -5.9 -0.31 9.02e-9 Neuroticism; LUSC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg14552801 chr7:65878734 NA 0.38 6.0 0.31 5.06e-9 Aortic root size; LUSC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg14784868 chr12:69753453 YEATS4 0.82 14.01 0.61 2.11e-35 Blood protein levels; LUSC cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg22117172 chr7:91764530 CYP51A1 0.32 5.72 0.3 2.42e-8 Breast cancer; LUSC cis rs2455601 0.507 rs2568044 chr11:9002477 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.44 6.97 0.36 1.69e-11 Schizophrenia; LUSC cis rs12458462 0.509 rs3786241 chr18:77494328 A/C cg11879182 chr18:77439856 CTDP1 0.54 8.22 0.41 4.6e-15 Monocyte count; LUSC cis rs11650494 0.516 rs117384420 chr17:47505383 G/C cg08112188 chr17:47440006 ZNF652 1.07 8.34 0.41 2.03e-15 Prostate cancer; LUSC cis rs4820539 1.000 rs4822358 chr22:23474795 A/G cg21100191 chr22:23484243 RTDR1 0.92 16.29 0.67 2.57e-44 Bone mineral density; LUSC cis rs748404 0.697 rs555001 chr15:43545728 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.94 0.31 7.05e-9 Lung cancer; LUSC cis rs9648716 0.515 rs801127 chr7:140728075 T/C cg23214464 chr7:140373596 ADCK2 -0.72 -6.24 -0.32 1.34e-9 Type 2 diabetes; LUSC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.68 0.34 9.8e-11 Melanoma; LUSC cis rs7584330 0.518 rs7585975 chr2:238439089 G/A cg14458575 chr2:238380390 NA 0.55 6.43 0.33 4.33e-10 Prostate cancer; LUSC cis rs1568889 0.775 rs35243076 chr11:28250618 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 12.81 0.57 7.89e-31 Bipolar disorder; LUSC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC cis rs977987 0.806 rs4888425 chr16:75476363 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.16 -0.36 5.2e-12 Dupuytren's disease; LUSC cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 8.91 0.44 3.25e-17 Axial length; LUSC cis rs1348850 0.872 rs10165785 chr2:178293295 C/T cg22681709 chr2:178499509 PDE11A -0.49 -9.13 -0.45 6.88e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg10792982 chr14:105748885 BRF1 0.5 8.97 0.44 2.14e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs2227564 0.620 rs7098573 chr10:75580014 G/A cg23231163 chr10:75533350 FUT11 -0.43 -6.3 -0.33 9.56e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7914558 0.646 rs10883795 chr10:104654577 T/C cg05855489 chr10:104503620 C10orf26 0.42 5.68 0.3 2.89e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.44 5.69 0.3 2.84e-8 Multiple sclerosis; LUSC cis rs921968 0.565 rs1079177 chr2:219605929 G/A cg02176678 chr2:219576539 TTLL4 -0.57 -10.1 -0.48 4.29e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg11584989 chr19:19387371 SF4 0.67 8.2 0.41 5.3e-15 Bipolar disorder; LUSC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg04317338 chr11:64019027 PLCB3 0.66 7.49 0.38 6.38e-13 Mean platelet volume; LUSC cis rs11098499 0.955 rs7684942 chr4:120162201 C/T cg09307838 chr4:120376055 NA 0.71 10.32 0.49 7.35e-22 Corneal astigmatism; LUSC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg26513180 chr16:89883248 FANCA 0.92 17.48 0.69 4.71e-49 Vitiligo; LUSC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg03433033 chr1:76189801 ACADM -0.76 -10.31 -0.49 8.21e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.13 0.52 1.13e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7831492 0.564 rs7831530 chr8:41614567 G/A cg17182837 chr8:41585554 ANK1 -0.29 -5.78 -0.3 1.68e-8 Colorectal cancer; LUSC cis rs3857536 0.813 rs9354403 chr6:66943426 A/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs4243830 0.510 rs7518459 chr1:6596678 C/G cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.05 -0.31 3.99e-9 Body mass index; LUSC cis rs6580649 0.883 rs1793955 chr12:48393106 G/T cg24011408 chr12:48396354 COL2A1 0.58 7.7 0.39 1.53e-13 Lung cancer; LUSC cis rs2708377 0.929 rs7298947 chr12:11311159 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg16928487 chr17:17741425 SREBF1 0.46 9.16 0.45 5.28e-18 Total body bone mineral density; LUSC cis rs34779708 0.966 rs12257770 chr10:35517234 A/G cg04310649 chr10:35416472 CREM -0.37 -5.85 -0.3 1.16e-8 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.78 -9.8 -0.47 4.12e-20 Gut microbiome composition (summer); LUSC cis rs897984 0.762 rs897986 chr16:30980902 T/C cg02466173 chr16:30829666 NA 0.55 11.19 0.52 6.81e-25 Dementia with Lewy bodies; LUSC trans rs3749237 1.000 rs1317140 chr3:49878652 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.47 6.26 0.32 1.2e-9 Resting heart rate; LUSC cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.46e-10 Body mass index; LUSC trans rs62458065 0.640 rs79619897 chr7:32514819 C/T cg00845942 chr12:64062724 DPY19L2 -0.57 -6.93 -0.35 2.24e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.56 -0.42 4.13e-16 Body mass index; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg02675527 chr2:114030824 PAX8;LOC440839 0.36 5.71 0.3 2.55e-8 Lymphocyte counts; LUSC trans rs6582630 0.519 rs4405392 chr12:38293661 A/C cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs9905704 0.627 rs6503867 chr17:56621359 T/C cg19466818 chr17:56409534 MIR142 0.35 6.46 0.33 3.78e-10 Testicular germ cell tumor; LUSC cis rs6977660 0.943 rs10254261 chr7:19846001 A/G cg05791153 chr7:19748676 TWISTNB -0.56 -6.31 -0.33 8.79e-10 Thyroid stimulating hormone; LUSC trans rs10098647 0.632 rs72663292 chr8:61111863 T/G cg09970348 chr3:183978600 ECE2;CAMK2N2 0.46 6.15 0.32 2.26e-9 Obesity-related traits; LUSC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg13393036 chr8:95962371 TP53INP1 -0.32 -6.18 -0.32 1.84e-9 Type 2 diabetes; LUSC cis rs28655083 0.529 rs4544253 chr16:77104774 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 7.11 0.36 7.24e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg05347473 chr6:146136440 FBXO30 -0.49 -8.28 -0.41 3.03e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs35146811 0.844 rs4424195 chr7:99642745 A/G cg22906224 chr7:99728672 NA 0.52 7.67 0.39 1.92e-13 Coronary artery disease; LUSC cis rs7818345 0.512 rs4922028 chr8:19303771 C/T cg11303988 chr8:19266685 CSGALNACT1 0.36 6.64 0.34 1.28e-10 Language performance in older adults (adjusted for episodic memory); LUSC cis rs4285028 0.747 rs1920299 chr3:121593769 A/G cg11130432 chr3:121712080 ILDR1 0.59 8.99 0.44 1.88e-17 Multiple sclerosis; LUSC cis rs4919694 1.000 rs12245343 chr10:104774050 A/G cg04362960 chr10:104952993 NT5C2 1.17 13.65 0.6 5.27e-34 Arsenic metabolism; LUSC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs7267979 0.565 rs6107060 chr20:25592476 C/G cg03522245 chr20:25566470 NINL 0.38 5.96 0.31 6.44e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs9473147 0.516 rs13212790 chr6:47576367 T/C cg20196966 chr6:47445060 CD2AP 0.43 6.09 0.32 3.06e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg06784218 chr1:46089804 CCDC17 -0.48 -9.21 -0.45 3.67e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3809566 0.963 rs4775608 chr15:63331940 A/G cg00520135 chr15:63333846 TPM1 -0.33 -6.66 -0.34 1.12e-10 Platelet count; LUSC cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg01579765 chr21:45077557 HSF2BP -0.53 -11.06 -0.52 1.88e-24 Mean corpuscular volume; LUSC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 3.03e-15 Tonsillectomy; LUSC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg05855489 chr10:104503620 C10orf26 -0.67 -9.67 -0.47 1.2e-19 Allergic disease (asthma, hay fever or eczema); LUSC cis rs807669 0.903 rs756651 chr22:19179367 T/C cg02655711 chr22:19163373 SLC25A1 0.91 17.84 0.7 1.74e-50 Metabolite levels; LUSC cis rs12220238 1.000 rs10824096 chr10:75937554 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.89 0.35 2.71e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg26513180 chr16:89883248 FANCA 0.78 6.39 0.33 5.68e-10 Skin colour saturation; LUSC trans rs4332037 0.539 rs4470910 chr7:2071723 C/T cg25206134 chr2:45395956 NA 0.59 6.91 0.35 2.4e-11 Bipolar disorder; LUSC cis rs11048434 0.736 rs56130437 chr12:9093001 G/A cg13575925 chr12:9217583 LOC144571 0.31 5.85 0.3 1.17e-8 Sjögren's syndrome; LUSC cis rs2455601 0.744 rs2163626 chr11:8983547 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -6.78 -0.35 5.54e-11 Schizophrenia; LUSC cis rs35096708 1.000 rs35096708 chr16:89887249 G/A cg07402062 chr16:89894098 SPIRE2 -0.38 -5.96 -0.31 6.29e-9 Skin aging (microtopography measurement); LUSC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.42 -0.33 4.63e-10 Total body bone mineral density; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg01125463 chr6:42946178 PEX6 -0.36 -6.12 -0.32 2.64e-9 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs459571 0.959 rs2073818 chr9:136918662 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -12.43 -0.56 2.02e-29 Platelet distribution width; LUSC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.66e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9399135 0.967 rs1041481 chr6:135335063 G/A cg22676075 chr6:135203613 NA 0.48 7.47 0.38 7.3e-13 Red blood cell count; LUSC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg21665744 chr7:39171113 POU6F2 0.48 7.68 0.39 1.72e-13 IgG glycosylation; LUSC cis rs4970988 0.526 rs6655975 chr1:150542128 A/G cg09365446 chr1:150670422 GOLPH3L -0.5 -7.08 -0.36 8.54e-12 Urate levels; LUSC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg19901468 chr14:105411992 AHNAK2 -0.71 -12.34 -0.56 4.38e-29 Rheumatoid arthritis; LUSC cis rs3772130 0.962 rs4413346 chr3:121486310 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.68 10.02 0.48 7.71e-21 Cognitive performance; LUSC cis rs7589342 0.536 rs1367405 chr2:106387141 G/A cg09152813 chr2:106391379 NCK2 -0.38 -6.24 -0.32 1.31e-9 Addiction; LUSC trans rs12310956 0.532 rs1352209 chr12:33983408 G/A cg13010199 chr12:38710504 ALG10B 0.52 7.72 0.39 1.34e-13 Morning vs. evening chronotype; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg15383120 chr6:291909 DUSP22 -0.66 -11.16 -0.52 8.5e-25 Menopause (age at onset); LUSC cis rs1560104 0.709 rs2217271 chr16:12704480 C/A cg02946846 chr16:12632861 SNX29 0.33 6.23 0.32 1.43e-9 Obesity-related traits; LUSC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg27572855 chr1:25598939 RHD 0.45 7.97 0.4 2.57e-14 Erythrocyte sedimentation rate; LUSC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -8.98 -0.44 1.99e-17 Gut microbiome composition (summer); LUSC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg15997130 chr1:24165203 NA -0.48 -8.05 -0.4 1.46e-14 Immature fraction of reticulocytes; LUSC trans rs35110281 0.776 rs62226866 chr21:45024186 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.51 0.53 4.93e-26 Mean corpuscular volume; LUSC cis rs6714788 0.503 rs11681737 chr2:100679024 T/C cg07810366 chr2:100720526 AFF3 -0.38 -6.03 -0.31 4.41e-9 Intelligence (multi-trait analysis); LUSC cis rs6598955 0.724 rs869683 chr1:26570993 T/A cg00852783 chr1:26633632 UBXN11 0.49 8.79 0.43 7.77e-17 Obesity-related traits; LUSC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.81 0.65 1.94e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg07703079 chr11:430292 ANO9 0.61 6.63 0.34 1.3100000000000001e-10 Body mass index; LUSC cis rs7542091 0.506 rs992976 chr1:210066658 A/T cg22029157 chr1:209979665 IRF6 -0.36 -5.69 -0.3 2.85e-8 Monobrow; LUSC cis rs782590 0.967 rs782588 chr2:55841640 T/C cg03859395 chr2:55845619 SMEK2 0.89 16.85 0.68 1.53e-46 Metabolic syndrome; LUSC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg06671706 chr8:8559999 CLDN23 0.48 6.58 0.34 1.86e-10 Obesity-related traits; LUSC cis rs2412208 0.609 rs10746465 chr1:7107231 C/A cg20434152 chr1:7120926 CAMTA1 -0.31 -6.11 -0.32 2.74e-9 Survival in sporadic amyotrophic lateral sclerosis; LUSC cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg00631329 chr6:26305371 NA -0.47 -9.3 -0.45 1.92e-18 Educational attainment; LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg04455712 chr21:45112962 RRP1B 0.45 8.53 0.42 5.06e-16 Mean corpuscular volume; LUSC cis rs3806843 0.549 rs246012 chr5:140336277 C/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs929354 1.000 rs8101 chr7:157061474 A/G cg17757837 chr7:157058334 UBE3C -0.9 -14.53 -0.62 2.07e-37 Body mass index; LUSC cis rs6547741 1.000 rs1972669 chr2:27767107 T/G cg27432699 chr2:27873401 GPN1 0.8 15.03 0.64 2.42e-39 Oral cavity cancer; LUSC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg22903471 chr2:27725779 GCKR -0.42 -7.11 -0.36 6.92e-12 Total body bone mineral density; LUSC cis rs7246967 0.551 rs7250608 chr19:22853056 C/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs500891 0.533 rs11969258 chr6:84127626 T/C cg08257003 chr6:84140564 ME1 0.37 9.11 0.45 7.86e-18 Platelet-derived growth factor BB levels; LUSC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg22244940 chr12:132335942 MMP17 0.45 6.79 0.35 5.11e-11 Migraine; LUSC cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg19318889 chr4:1322082 MAEA 0.45 7.41 0.38 1.06e-12 Obesity-related traits; LUSC cis rs4845570 1.000 rs4845356 chr1:151759223 T/A cg07092448 chr1:151763213 TDRKH 1.22 14.82 0.63 1.49e-38 Coronary artery disease; LUSC cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg07741184 chr6:167504864 NA 0.37 6.69 0.34 9.31e-11 Crohn's disease; LUSC cis rs11105298 0.891 rs10858879 chr12:89886578 A/T cg00757033 chr12:89920650 WDR51B -0.55 -9.31 -0.45 1.8e-18 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg04362960 chr10:104952993 NT5C2 0.58 9.18 0.45 4.58e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs11039798 0.512 rs1588069 chr11:48694871 A/G cg03929089 chr4:120376271 NA 0.67 7.39 0.37 1.2e-12 Axial length; LUSC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg19717773 chr7:2847554 GNA12 -0.34 -5.76 -0.3 1.9e-8 Height; LUSC cis rs7615952 0.546 rs112919177 chr3:125346070 G/A cg05084668 chr3:125655381 ALG1L -0.45 -6.02 -0.31 4.67e-9 Blood pressure (smoking interaction); LUSC cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg03433033 chr1:76189801 ACADM -0.48 -7.28 -0.37 2.43e-12 Daytime sleep phenotypes; LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13012494 chr21:47604986 C21orf56 0.47 7.23 0.37 3.3e-12 Testicular germ cell tumor; LUSC trans rs11681884 0.786 rs1992762 chr2:113810413 G/A cg19632953 chr13:113635898 MCF2L 0.69 6.03 0.31 4.45e-9 Stroke; LUSC cis rs7267979 0.833 rs4619688 chr20:25244101 C/G cg08601574 chr20:25228251 PYGB 0.47 7.28 0.37 2.43e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.09 21.92 0.77 1.22e-66 Cognitive ability; LUSC cis rs7267979 0.586 rs6050431 chr20:25183908 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.48 0.56 1.32e-29 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1941687 0.505 rs8091920 chr18:31303557 C/G cg27147174 chr7:100797783 AP1S1 -0.54 -8.27 -0.41 3.31e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg08392591 chr16:89556376 ANKRD11 0.5 7.76 0.39 1.04e-13 Multiple myeloma (IgH translocation); LUSC cis rs5758659 0.716 rs5758661 chr22:42624445 A/C cg00645731 chr22:42541494 CYP2D7P1 -0.31 -6.41 -0.33 4.84e-10 Cognitive function; LUSC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg05425664 chr17:57184151 TRIM37 0.52 7.73 0.39 1.31e-13 Intelligence (multi-trait analysis); LUSC cis rs4268898 0.795 rs12470303 chr2:24619883 C/T cg06627628 chr2:24431161 ITSN2 -0.54 -7.79 -0.39 8.48e-14 Asthma; LUSC trans rs4332037 0.539 rs55988458 chr7:2059761 G/A cg10840412 chr1:235813424 GNG4 0.57 7.34 0.37 1.61e-12 Bipolar disorder; LUSC cis rs10193935 0.901 rs6733914 chr2:42674741 A/G cg27598129 chr2:42591480 NA 0.61 8.29 0.41 2.74e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs4555082 0.874 rs28785556 chr14:105745388 A/T cg13114125 chr14:105738426 BRF1 -0.96 -16.12 -0.66 1.23e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg13395646 chr4:1353034 KIAA1530 0.49 7.02 0.36 1.23e-11 Obesity-related traits; LUSC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.95e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs3942852 0.568 rs6485807 chr11:48102867 G/A cg15704280 chr7:45808275 SEPT13 -0.62 -8.11 -0.41 9.44e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs2019216 0.500 rs908696 chr17:21940987 T/G cg22648282 chr17:21454238 C17orf51 -0.49 -6.88 -0.35 2.93e-11 Pelvic organ prolapse; LUSC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg04352962 chr1:209979756 IRF6 0.56 6.65 0.34 1.19e-10 Cleft lip with or without cleft palate; LUSC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.49 -8.47 -0.42 8.14e-16 Lymphocyte counts; LUSC cis rs897080 0.552 rs1067388 chr2:44642482 G/A cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.51e-8 Height; LUSC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg22105103 chr4:187893119 NA 0.72 14.07 0.61 1.2e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467773 1.000 rs9467797 chr6:26568473 A/T cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg09436375 chr6:42928200 GNMT -0.3 -7.01 -0.36 1.29e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs11098499 0.908 rs9995234 chr4:120321827 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.06 0.31 3.58e-9 Corneal astigmatism; LUSC cis rs12421382 0.543 rs11213094 chr11:109357926 G/A cg27471124 chr11:109292789 C11orf87 0.55 9.75 0.47 6.06e-20 Schizophrenia; LUSC cis rs9880211 0.821 rs9832813 chr3:136065565 A/G cg21827317 chr3:136751795 NA -0.38 -5.94 -0.31 7.15e-9 Body mass index;Height; LUSC cis rs4601821 0.823 rs17115439 chr11:113264272 T/C cg14159747 chr11:113255604 NA 0.25 6.09 0.32 3.06e-9 Alcoholic chronic pancreatitis; LUSC cis rs34734847 0.965 rs2005455 chr12:121128699 A/G cg27246729 chr12:121163418 ACADS 0.47 7.43 0.38 8.96e-13 Mean corpuscular volume; LUSC cis rs11785693 0.862 rs17435835 chr8:5000713 C/T cg26367366 chr8:4980734 NA -0.84 -9.75 -0.47 6.35e-20 Neuroticism (multi-trait analysis);Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18387017 chr1:1167389 SDF4;B3GALT6 -0.42 -6.35 -0.33 6.92e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1005277 0.579 rs2505198 chr10:38393183 A/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.63 -0.47 1.62e-19 Extrinsic epigenetic age acceleration; LUSC cis rs10450586 0.965 rs10450589 chr11:27308819 A/C cg08958251 chr11:27270390 NA 0.35 5.8 0.3 1.52e-8 Total body bone mineral density; LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg14784868 chr12:69753453 YEATS4 -0.58 -7.42 -0.38 9.63e-13 Response to diuretic therapy; LUSC trans rs7937682 0.632 rs14133 chr11:111782697 C/G cg18187862 chr3:45730750 SACM1L -0.51 -6.3 -0.33 9.63e-10 Primary sclerosing cholangitis; LUSC cis rs7707921 0.881 rs324910 chr5:81400264 A/C cg15871215 chr5:81402204 ATG10 -0.44 -6.35 -0.33 7.22e-10 Breast cancer; LUSC cis rs174479 0.647 rs174461 chr11:61657401 A/C cg01500311 chr11:61656094 FADS3 0.4 6.96 0.36 1.8e-11 Sphingolipid levels; LUSC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg16680214 chr1:154839983 KCNN3 -0.51 -9.68 -0.47 1.08e-19 Prostate cancer; LUSC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.24e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg10556349 chr10:835070 NA 0.44 5.68 0.3 2.96e-8 Eosinophil percentage of granulocytes; LUSC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg14552801 chr7:65878734 NA -0.45 -6.52 -0.34 2.66e-10 Aortic root size; LUSC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 8.84 0.44 5.48e-17 Schizophrenia; LUSC cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg16850897 chr7:100343110 ZAN -0.61 -8.5 -0.42 6.61e-16 Other erythrocyte phenotypes; LUSC trans rs3942852 0.868 rs7118226 chr11:48106267 T/G cg03929089 chr4:120376271 NA -0.54 -6.15 -0.32 2.26e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg13010199 chr12:38710504 ALG10B 0.49 7.48 0.38 6.79e-13 Morning vs. evening chronotype; LUSC cis rs13064411 0.735 rs9875025 chr3:113147552 T/C cg18753928 chr3:113234510 CCDC52 -0.44 -6.66 -0.34 1.14e-10 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs12956009 0.583 rs12960952 chr18:44857476 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.22 0.32 1.48e-9 Educational attainment (years of education); LUSC cis rs6500602 1.000 rs7204827 chr16:4467533 C/T cg08645402 chr16:4508243 NA 0.51 8.42 0.42 1.15e-15 Schizophrenia; LUSC cis rs6598955 0.543 rs12122527 chr1:26549748 C/T cg04990556 chr1:26633338 UBXN11 0.8 10.39 0.49 4.34e-22 Obesity-related traits; LUSC cis rs7903847 0.642 rs11189204 chr10:99164394 C/T cg20016023 chr10:99160130 RRP12 -0.3 -7.37 -0.37 1.38e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs1044826 1.000 rs3772878 chr3:139187375 T/C cg00490450 chr3:139108681 COPB2 0.51 6.59 0.34 1.71e-10 Obesity-related traits; LUSC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg03806693 chr22:41940476 POLR3H -0.99 -14.04 -0.61 1.62e-35 Vitiligo; LUSC cis rs7582180 0.563 rs4851304 chr2:100963871 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.88 -0.44 4.32e-17 Intelligence (multi-trait analysis); LUSC trans rs62238980 0.614 rs117305417 chr22:32400975 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.58 -0.34 1.79e-10 Bipolar disorder and schizophrenia; LUSC cis rs1577917 0.839 rs1838956 chr6:86565263 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.29 -0.33 9.98e-10 Response to antipsychotic treatment; LUSC cis rs782590 0.935 rs6739513 chr2:55749902 G/A cg18811423 chr2:55921094 PNPT1 0.82 14.35 0.62 1.04e-36 Metabolic syndrome; LUSC cis rs7072216 0.770 rs1737 chr10:100176366 T/C cg26618903 chr10:100175079 PYROXD2 -0.35 -6.99 -0.36 1.49e-11 Metabolite levels; LUSC cis rs1881396 0.945 rs1881397 chr2:27832285 A/G cg27432699 chr2:27873401 GPN1 0.57 7.85 0.39 5.61e-14 Nonalcoholic fatty liver disease; LUSC cis rs10208940 0.920 rs72903979 chr2:68813938 C/T cg12452813 chr2:68675892 NA 0.59 6.08 0.32 3.21e-9 Urate levels in lean individuals; LUSC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg00409905 chr10:38381863 ZNF37A -0.35 -5.98 -0.31 5.62e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6500395 1.000 rs12933948 chr16:48705825 C/G cg04672837 chr16:48644449 N4BP1 -0.46 -6.8 -0.35 4.83e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs6977660 1.000 rs6973890 chr7:19820497 T/C cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.95 15.71 0.65 4.82e-42 Platelet count; LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg05552183 chr6:42928497 GNMT 0.48 8.09 0.4 1.11e-14 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs8073060 0.586 rs2626625 chr17:34027607 C/G cg19694781 chr19:47549865 TMEM160 -1.13 -17.99 -0.7 4.71e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs12042938 0.935 rs1417585 chr1:231803604 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.43 6.25 0.32 1.23e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs1957429 0.520 rs72625641 chr14:65335761 C/T cg23373153 chr14:65346875 NA -0.87 -7.56 -0.38 4.04e-13 Pediatric areal bone mineral density (radius); LUSC cis rs983392 0.805 rs2081545 chr11:59958380 C/A cg20284999 chr11:59952153 MS4A6A -0.39 -6.38 -0.33 6.06e-10 Alzheimer's disease (late onset); LUSC cis rs2235649 0.833 rs7189070 chr16:1850813 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.08 -0.32 3.22e-9 Blood metabolite levels; LUSC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg17971929 chr21:40555470 PSMG1 0.79 13.82 0.6 1.1e-34 Cognitive function; LUSC cis rs1371867 0.846 rs1692007 chr8:101268343 T/C cg06002616 chr8:101225028 SPAG1 0.39 6.57 0.34 1.97e-10 Atrioventricular conduction; LUSC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg11812906 chr14:75593930 NEK9 -0.65 -10.95 -0.51 4.58e-24 Height; LUSC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg02951883 chr7:2050386 MAD1L1 -0.61 -11.5 -0.53 5.37e-26 Bipolar disorder and schizophrenia; LUSC cis rs6541297 0.793 rs6692319 chr1:230284375 C/T cg05784532 chr1:230284198 GALNT2 0.55 8.18 0.41 6.09e-15 Coronary artery disease; LUSC cis rs6840360 0.967 rs6823423 chr4:152604723 T/C cg22705602 chr4:152727874 NA -0.28 -5.96 -0.31 6.43e-9 Intelligence (multi-trait analysis); LUSC cis rs870825 0.616 rs28416641 chr4:185617999 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs2180341 0.618 rs11961994 chr6:127649350 A/G cg24812749 chr6:127587940 RNF146 -0.65 -9.68 -0.47 1.09e-19 Breast cancer; LUSC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs57221529 0.766 rs72703026 chr5:572383 G/A cg25482853 chr8:67687455 SGK3 1.18 16.46 0.67 5.32e-45 Lung disease severity in cystic fibrosis; LUSC cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg01444801 chr10:135216882 MTG1 -0.48 -6.59 -0.34 1.67e-10 Systemic lupus erythematosus; LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.67 0.34 1.07e-10 Menopause (age at onset); LUSC trans rs6076960 0.652 rs6085467 chr20:6259004 T/C cg21095983 chr6:86352623 SYNCRIP 0.5 7.98 0.4 2.44e-14 Smooth-surface caries; LUSC cis rs929354 0.742 rs6459734 chr7:156935454 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.52 -0.46 3.68e-19 Body mass index; LUSC trans rs3733585 0.699 rs12498956 chr4:9950705 G/T cg26043149 chr18:55253948 FECH -0.45 -7.1 -0.36 7.71e-12 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17836109 chr8:99129518 POP1;HRSP12 -0.43 -6.34 -0.33 7.49e-10 Electrocardiographic conduction measures; LUSC cis rs394563 0.967 rs420099 chr6:149794290 A/C cg11245181 chr6:149772854 ZC3H12D -0.29 -6.21 -0.32 1.57e-9 Dupuytren's disease; LUSC cis rs36093844 0.948 rs11234451 chr11:85573702 T/A cg25872744 chr11:85566296 CCDC83 -0.5 -7.69 -0.39 1.67e-13 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6969780 0.915 rs7341470 chr7:27184842 T/C cg26364809 chr7:27145159 NA 0.52 5.69 0.3 2.71e-8 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg01579765 chr21:45077557 HSF2BP -0.5 -10.39 -0.49 4.12e-22 Mean corpuscular volume; LUSC cis rs7193541 0.508 rs7188581 chr16:74672901 T/A cg01733217 chr16:74700730 RFWD3 0.98 21.68 0.76 1.13e-65 Multiple myeloma; LUSC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg24642844 chr7:1081250 C7orf50 -0.46 -7.57 -0.38 3.74e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs12692738 0.526 rs355868 chr2:165631194 C/T cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34330 0.562 rs10845615 chr12:12863470 C/T cg09462578 chr12:12878428 APOLD1 -0.68 -8.1 -0.41 1.02e-14 Systemic lupus erythematosus; LUSC cis rs9929218 1.000 rs7200690 chr16:68778457 C/T cg02972257 chr16:68554789 NA 0.42 5.73 0.3 2.3e-8 Colorectal cancer; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg17178900 chr1:205818956 PM20D1 0.8 13.47 0.59 2.48e-33 Menarche (age at onset); LUSC trans rs13233308 0.836 rs6966166 chr7:87455155 C/T cg11015188 chr12:123874456 SETD8 -0.44 -6.22 -0.32 1.46e-9 Schizophrenia; LUSC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg23791538 chr6:167370224 RNASET2 0.4 6.57 0.34 1.98e-10 Crohn's disease; LUSC cis rs701145 0.938 rs1515653 chr3:154076654 A/G cg17054900 chr3:154042577 DHX36 0.78 7.81 0.39 7.31e-14 Coronary artery disease; LUSC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.55 -0.42 4.48e-16 Personality dimensions; LUSC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg04414720 chr1:150670196 GOLPH3L -0.53 -8.69 -0.43 1.66e-16 Tonsillectomy; LUSC cis rs9547692 0.877 rs9652258 chr13:37476123 G/C cg01493522 chr13:37497338 NA -0.44 -6.36 -0.33 6.59e-10 Coronary artery disease; LUSC cis rs9616064 0.506 rs3747255 chr22:47074281 G/A cg05621596 chr22:47072043 GRAMD4 -0.59 -9.48 -0.46 4.88e-19 Urate levels in obese individuals; LUSC cis rs6964587 0.967 rs7788092 chr7:91646198 C/T cg17063962 chr7:91808500 NA 0.57 9.07 0.44 1.02e-17 Breast cancer; LUSC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg27165867 chr14:105738592 BRF1 -0.5 -7.48 -0.38 6.57e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.83 -0.57 6.66e-31 Chronic sinus infection; LUSC trans rs34844492 0.744 rs17072704 chr3:65271885 C/T cg03649855 chr6:45576388 NA 0.66 6.38 0.33 6.03e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs12210905 0.925 rs114172511 chr6:26964301 G/A cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC trans rs931812 0.535 rs3100053 chr8:101944559 T/A cg20993868 chr7:22813445 NA 0.34 6.28 0.32 1.07e-9 Attention deficit hyperactivity disorder and conduct disorder; LUSC trans rs9329221 0.527 rs4841351 chr8:10327367 G/A cg06636001 chr8:8085503 FLJ10661 -0.43 -5.99 -0.31 5.32e-9 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25223263 chr11:119020168 ABCG4 -0.48 -6.45 -0.33 3.88e-10 Bipolar disorder and schizophrenia; LUSC cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.93 0.35 2.16e-11 Rheumatoid arthritis; LUSC cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg08999081 chr20:33150536 PIGU -0.41 -7.49 -0.38 6.06e-13 Glomerular filtration rate (creatinine); LUSC cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.53 -8.04 -0.4 1.62e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs757110 0.740 rs10832776 chr11:17385224 C/A cg15432903 chr11:17409602 KCNJ11 0.6 10.54 0.5 1.28e-22 Type 2 diabetes; LUSC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.03 0.48 7.25e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs3125734 0.633 rs3765002 chr10:64006124 G/T cg09941381 chr10:64027924 RTKN2 -0.38 -7.0 -0.36 1.45e-11 Rheumatoid arthritis; LUSC cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs13221852 0.714 rs34731314 chr7:3438362 T/C cg21248987 chr7:3385318 SDK1 0.36 5.95 0.31 6.87e-9 Acute graft versus host disease in bone marrow transplantation (donor effect); LUSC cis rs713587 1.000 rs2384054 chr2:25156773 T/C cg15423357 chr2:25149977 NA 0.44 8.91 0.44 3.26e-17 Body mass index in non-asthmatics; LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg17330251 chr7:94953956 PON1 -0.63 -13.2 -0.59 2.6e-32 Paraoxonase activity; LUSC cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg18681998 chr4:17616180 MED28 0.86 15.28 0.64 2.39e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7527798 0.592 rs1323722 chr1:207823405 C/T cg09232269 chr1:207846808 CR1L -0.3 -6.43 -0.33 4.37e-10 Erythrocyte sedimentation rate; LUSC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.954 rs6820115 chr4:120398182 T/C cg25214090 chr10:38739885 LOC399744 0.5 7.67 0.39 1.86e-13 Corneal astigmatism; LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 13.71 0.6 2.98e-34 Platelet count; LUSC cis rs2762353 0.902 rs1165199 chr6:25809087 C/T cg03264133 chr6:25882463 NA -0.42 -7.28 -0.37 2.42e-12 Blood metabolite levels; LUSC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg15704280 chr7:45808275 SEPT13 -1.08 -19.72 -0.73 6.12e-58 Coronary artery disease; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg09877947 chr5:131593287 PDLIM4 0.43 7.31 0.37 1.99e-12 Blood metabolite levels; LUSC cis rs34638657 0.828 rs7194734 chr16:82199980 C/T cg09439754 chr16:82129088 HSD17B2 -0.39 -6.0 -0.31 5.19e-9 Lung adenocarcinoma; LUSC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg12927641 chr6:109611667 NA -0.37 -6.21 -0.32 1.56e-9 Reticulocyte fraction of red cells; LUSC cis rs9325144 0.624 rs12231544 chr12:38901956 C/T cg26384229 chr12:38710491 ALG10B -0.59 -9.09 -0.45 9.13e-18 Morning vs. evening chronotype; LUSC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg02807482 chr3:125708958 NA -0.51 -6.31 -0.33 9e-10 Blood pressure (smoking interaction); LUSC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.22 -0.37 3.46e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg15423357 chr2:25149977 NA 0.45 9.13 0.45 6.59e-18 Body mass index; LUSC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg03806693 chr22:41940476 POLR3H -1.05 -15.17 -0.64 6.42e-40 Vitiligo; LUSC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg06221963 chr1:154839813 KCNN3 -0.6 -13.52 -0.59 1.57e-33 Prostate cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07243161 chr6:136871709 MAP7 -0.4 -6.19 -0.32 1.81e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs62238980 0.522 rs117086479 chr22:32389342 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs858239 0.601 rs10278700 chr7:23160529 T/C cg23682824 chr7:23144976 KLHL7 0.39 5.69 0.3 2.85e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg08048268 chr3:133502702 NA -0.38 -6.82 -0.35 4.23e-11 Iron status biomarkers; LUSC cis rs11098499 0.954 rs10006877 chr4:120242793 C/T cg24375607 chr4:120327624 NA 0.8 11.96 0.55 1.14e-27 Corneal astigmatism; LUSC cis rs67072384 0.818 rs2291293 chr11:72470653 C/T cg04827223 chr11:72435913 ARAP1 -0.86 -6.75 -0.35 6.36e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs782590 0.783 rs7594279 chr2:55812073 T/G cg03859395 chr2:55845619 SMEK2 0.88 16.43 0.67 6.84e-45 Metabolic syndrome; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg10802521 chr3:52805072 NEK4 -0.48 -7.61 -0.38 2.87e-13 Electroencephalogram traits; LUSC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.46 0.5 2.54e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9815354 0.767 rs73087378 chr3:41936827 G/A cg03022575 chr3:42003672 ULK4 0.83 8.64 0.43 2.32e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4242434 0.747 rs6986550 chr8:22467870 T/A cg03733263 chr8:22462867 KIAA1967 0.84 14.18 0.61 4.64e-36 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg12257692 chr3:49977190 RBM6 -0.26 -7.41 -0.38 1.03e-12 Body mass index; LUSC trans rs12439619 0.693 rs28665836 chr15:82511296 G/T cg04831495 chr15:85060580 GOLGA6L5 -0.49 -8.15 -0.41 7.64e-15 Intelligence (multi-trait analysis); LUSC cis rs2667011 0.512 rs1995951 chr2:160800952 G/A cg06573604 chr2:160760825 LY75 0.45 6.28 0.32 1.07e-9 Bilirubin levels; LUSC cis rs11098499 0.913 rs11098496 chr4:120167466 C/G cg24375607 chr4:120327624 NA 0.74 11.16 0.52 8.3e-25 Corneal astigmatism; LUSC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg12927641 chr6:109611667 NA 0.34 5.81 0.3 1.5e-8 Reticulocyte fraction of red cells; LUSC trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -8.64 -0.43 2.29e-16 Myopia (pathological); LUSC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg06618935 chr21:46677482 NA -0.4 -7.74 -0.39 1.16e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg24675056 chr1:15929824 NA 0.48 8.33 0.41 2.17e-15 Systolic blood pressure; LUSC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg27432699 chr2:27873401 GPN1 -0.58 -8.68 -0.43 1.72e-16 Total body bone mineral density; LUSC cis rs9443645 0.527 rs10943588 chr6:79510994 A/C cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.1 -0.32 2.9e-9 Intelligence (multi-trait analysis); LUSC cis rs3087591 0.960 rs4263003 chr17:29438508 G/T cg24425628 chr17:29625626 OMG;NF1 0.54 7.5 0.38 5.66e-13 Hip circumference; LUSC cis rs12291225 0.585 rs11023194 chr11:14369769 T/C cg05501817 chr11:14380813 RRAS2 -0.56 -9.23 -0.45 3.29e-18 Sense of smell; LUSC cis rs11098499 0.863 rs3775854 chr4:120471971 C/T cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs11711311 0.955 rs11715350 chr3:113418376 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.67 -0.3 3.1e-8 IgG glycosylation; LUSC cis rs1014246 0.848 rs10787716 chr10:118459575 C/A cg14919929 chr10:118506882 NA 0.45 7.19 0.37 4.23e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg24675056 chr1:15929824 NA 0.49 8.46 0.42 8.28e-16 Systolic blood pressure; LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg16145915 chr7:1198662 ZFAND2A -0.5 -9.13 -0.45 6.74e-18 Longevity;Endometriosis; LUSC cis rs897984 0.568 rs8063565 chr16:30883965 G/C cg02466173 chr16:30829666 NA 0.52 8.36 0.42 1.75e-15 Dementia with Lewy bodies; LUSC cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg08999081 chr20:33150536 PIGU -0.54 -10.72 -0.51 2.94e-23 Glomerular filtration rate (creatinine); LUSC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg05872129 chr22:39784769 NA 0.57 9.48 0.46 4.73e-19 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11190604 1.000 rs2495758 chr10:102321900 C/G cg07080220 chr10:102295463 HIF1AN 0.7 8.39 0.42 1.39e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg08219700 chr8:58056026 NA 0.46 5.74 0.3 2.1e-8 Developmental language disorder (linguistic errors); LUSC cis rs2580764 0.632 rs2588510 chr2:55199248 A/G cg09592903 chr2:55203963 RTN4 -0.48 -10.0 -0.48 8.82e-21 Mean platelet volume; LUSC cis rs367943 1.000 rs348961 chr5:112819944 A/C cg12552261 chr5:112820674 MCC -0.54 -7.0 -0.36 1.45e-11 Type 2 diabetes; LUSC cis rs17253792 0.822 rs9972178 chr14:56073480 A/G cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.9e-12 Putamen volume; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg24813613 chr7:1882135 MAD1L1 0.35 5.81 0.3 1.42e-8 Bipolar disorder and schizophrenia; LUSC trans rs8073060 0.544 rs1080352 chr17:34002362 A/G cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.754 rs2964 chr4:120240131 T/C cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC cis rs7904368 1.000 rs7904368 chr10:16858587 C/T cg14835575 chr10:16859367 RSU1 0.72 10.05 0.48 5.94e-21 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg06808227 chr14:105710500 BRF1 -0.65 -9.57 -0.46 2.42e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs6709815 0.841 rs6740004 chr2:219663153 G/A cg02176678 chr2:219576539 TTLL4 -0.51 -9.02 -0.44 1.46e-17 Reticulocyte count;High light scatter reticulocyte count; LUSC cis rs11098499 0.954 rs3733519 chr4:120423448 A/G cg24375607 chr4:120327624 NA 0.79 11.99 0.55 8.46e-28 Corneal astigmatism; LUSC cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.5 -7.59 -0.38 3.2e-13 Menarche (age at onset); LUSC cis rs1215050 0.765 rs6852699 chr4:98767505 T/C cg05340658 chr4:99064831 C4orf37 0.44 6.97 0.36 1.68e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg06238570 chr21:40685208 BRWD1 0.48 7.35 0.37 1.55e-12 Cognitive function; LUSC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg24209194 chr3:40518798 ZNF619 0.44 5.9 0.31 8.9e-9 Renal cell carcinoma; LUSC cis rs17685 0.775 rs11761172 chr7:75761547 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs11792861 0.781 rs17729408 chr9:111740860 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.58 -8.57 -0.42 3.9e-16 Menarche (age at onset); LUSC cis rs6582630 0.538 rs8189550 chr12:38333058 T/G cg13010199 chr12:38710504 ALG10B -0.45 -6.62 -0.34 1.42e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg22508957 chr16:3507546 NAT15 0.43 6.15 0.32 2.21e-9 Body mass index (adult); LUSC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg04727924 chr7:799746 HEATR2 -0.55 -6.67 -0.34 1.07e-10 Cerebrospinal P-tau181p levels; LUSC cis rs2204008 0.527 rs1315367 chr12:38177487 G/T cg13010199 chr12:38710504 ALG10B -0.52 -7.91 -0.4 3.93e-14 Bladder cancer; LUSC cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.21 -0.37 3.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg02951883 chr7:2050386 MAD1L1 -0.59 -10.62 -0.5 6.87e-23 Bipolar disorder and schizophrenia; LUSC cis rs9549260 0.683 rs35594717 chr13:41240783 G/A cg21288729 chr13:41239152 FOXO1 0.57 6.34 0.33 7.56e-10 Red blood cell count; LUSC cis rs4919687 0.550 rs12761195 chr10:104465374 T/C cg05855489 chr10:104503620 C10orf26 0.71 11.49 0.53 5.76e-26 Colorectal cancer; LUSC cis rs911555 0.504 rs4444269 chr14:104072724 G/C cg12935359 chr14:103987150 CKB -0.51 -7.86 -0.4 5.37e-14 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 5.1e-14 Prudent dietary pattern; LUSC cis rs1577917 0.916 rs12206726 chr6:86499716 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.82 -0.35 4.34e-11 Response to antipsychotic treatment; LUSC cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.21 0.49 1.83e-21 Bladder cancer; LUSC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg13902645 chr11:5959945 NA -0.6 -8.48 -0.42 7.55e-16 DNA methylation (variation); LUSC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg11764359 chr7:65958608 NA -0.54 -7.11 -0.36 7.23e-12 Aortic root size; LUSC cis rs727505 0.754 rs56056794 chr7:124783027 C/T cg23710748 chr7:124431027 NA -0.41 -7.13 -0.36 6.4e-12 Lewy body disease; LUSC cis rs362272 0.505 rs3129310 chr4:3301388 T/G cg14583973 chr4:3374767 RGS12 0.33 7.13 0.36 6.11e-12 Serum sulfate level; LUSC cis rs734999 0.545 rs7368072 chr1:2556125 C/T cg18932078 chr1:2524107 MMEL1 0.31 6.92 0.35 2.35e-11 Ulcerative colitis; LUSC cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg08704250 chr15:31115839 NA -0.46 -6.72 -0.35 7.9e-11 Huntington's disease progression; LUSC cis rs950027 0.596 rs2467865 chr15:45638307 T/C cg04036182 chr15:45458818 NA 0.34 5.74 0.3 2.13e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs9811920 0.809 rs4928235 chr3:99706870 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 5.8 0.3 1.58e-8 Axial length; LUSC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg08213375 chr14:104286397 PPP1R13B 0.44 7.58 0.38 3.4e-13 Reticulocyte count; LUSC cis rs9788682 1.000 rs12441354 chr15:78821016 G/A cg18825076 chr15:78729989 IREB2 0.45 6.03 0.31 4.4e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs10986311 0.802 rs2416 chr9:127113660 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.45 7.21 0.37 3.67e-12 Vitiligo; LUSC cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.61 8.3 0.41 2.59e-15 Body mass index (adult); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09154213 chr1:25756855 TMEM57 0.49 7.38 0.37 1.29e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12410462 0.579 rs115037090 chr1:227666191 A/G cg04117972 chr1:227635322 NA 0.79 7.96 0.4 2.69e-14 Major depressive disorder; LUSC cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg13010199 chr12:38710504 ALG10B 0.67 11.15 0.52 9.01e-25 Heart rate; LUSC cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.7 -0.3 2.66e-8 Extrinsic epigenetic age acceleration; LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg10729496 chr3:10149963 C3orf24 0.54 7.15 0.36 5.46e-12 Alzheimer's disease; LUSC cis rs12908161 0.959 rs17534709 chr15:85314397 G/C cg17173187 chr15:85201210 NMB 0.5 9.15 0.45 5.81e-18 Schizophrenia; LUSC cis rs60154123 0.614 rs646512 chr1:210453938 C/T cg22029157 chr1:209979665 IRF6 -0.5 -6.05 -0.31 3.83e-9 Coronary artery disease; LUSC cis rs4343996 0.536 rs10258056 chr7:3414624 C/T cg21248987 chr7:3385318 SDK1 0.36 6.17 0.32 2.02e-9 Motion sickness; LUSC cis rs2625529 0.526 rs11637611 chr15:72551712 C/T cg16672083 chr15:72433130 SENP8 0.46 7.76 0.39 1.02e-13 Red blood cell count; LUSC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.35 0.37 1.5e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9650315 0.641 rs56054219 chr8:57186076 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.45 0.38 7.92e-13 Height; LUSC cis rs11650494 0.706 rs76778410 chr17:47459877 A/T cg08112188 chr17:47440006 ZNF652 1.31 10.82 0.51 1.41e-23 Prostate cancer; LUSC trans rs7937682 0.921 rs11213940 chr11:111433927 C/A cg18187862 chr3:45730750 SACM1L -0.52 -6.49 -0.33 3.17e-10 Primary sclerosing cholangitis; LUSC cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg21535247 chr6:8435926 SLC35B3 0.6 9.27 0.45 2.37e-18 Motion sickness; LUSC cis rs2688608 0.967 rs2633299 chr10:75656754 T/G cg17411546 chr10:75410026 SYNPO2L -0.46 -6.84 -0.35 3.77e-11 Inflammatory bowel disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20151668 chr10:27150052 ABI1 0.52 8.19 0.41 5.49e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.83 -0.57 6.66e-31 Chronic sinus infection; LUSC trans rs2243480 1.000 rs2460422 chr7:65601505 C/T cg10756647 chr7:56101905 PSPH 0.89 8.94 0.44 2.61e-17 Diabetic kidney disease; LUSC cis rs1153858 0.943 rs1145079 chr15:45681761 T/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.01 0.4 1.93e-14 Homoarginine levels; LUSC cis rs7572644 0.766 rs10188108 chr2:28192555 C/G cg27432699 chr2:27873401 GPN1 -0.52 -6.45 -0.33 3.97e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15921099 chr2:121010219 RALB -0.44 -6.62 -0.34 1.39e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg02018176 chr4:1364513 KIAA1530 0.57 10.15 0.49 2.91e-21 Obesity-related traits; LUSC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg14403583 chr14:105418241 AHNAK2 -0.58 -9.65 -0.47 1.38e-19 Rheumatoid arthritis; LUSC cis rs654950 0.792 rs625448 chr1:41988541 A/T cg06885757 chr1:42089581 HIVEP3 0.34 6.63 0.34 1.33e-10 Airway imaging phenotypes; LUSC cis rs12579753 0.917 rs7306043 chr12:82191282 G/A cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg17554472 chr22:41940697 POLR3H 0.48 5.91 0.31 8.32e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6840360 0.533 rs13121190 chr4:152729072 T/G cg22705602 chr4:152727874 NA 0.36 7.68 0.39 1.79e-13 Intelligence (multi-trait analysis); LUSC trans rs6445525 0.967 rs6782159 chr3:65993782 C/G cg12639933 chr12:57626296 SHMT2 0.36 6.43 0.33 4.51e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1670533 1.000 rs6857085 chr4:1095920 C/A cg16405210 chr4:1374714 KIAA1530 0.46 5.67 0.3 3.02e-8 Recombination rate (females); LUSC cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg24812749 chr6:127587940 RNF146 0.92 13.89 0.61 6.05e-35 Breast cancer; LUSC cis rs9372253 0.678 rs6568644 chr6:110707820 C/T cg19196401 chr6:110721138 DDO -0.43 -8.09 -0.4 1.1e-14 Platelet distribution width; LUSC cis rs7043114 0.525 rs1053446 chr9:95146761 T/A cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.78 -0.35 5.6e-11 Height; LUSC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg18225595 chr11:63971243 STIP1 0.62 10.08 0.48 5.04e-21 Platelet count; LUSC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg20891558 chr2:74357851 NA 0.79 14.23 0.61 2.92e-36 Gestational age at birth (maternal effect); LUSC cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg07606381 chr6:8435919 SLC35B3 -0.73 -12.29 -0.56 7e-29 Motion sickness; LUSC cis rs6582630 0.576 rs4882372 chr12:38356609 C/A cg13010199 chr12:38710504 ALG10B -0.45 -6.66 -0.34 1.1e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7208859 0.524 rs57670615 chr17:29069498 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9473147 0.543 rs9296559 chr6:47452270 T/C cg12968598 chr6:47444699 CD2AP 0.53 8.14 0.41 8.1e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs11098499 0.569 rs10023641 chr4:120258410 C/G cg09307838 chr4:120376055 NA 0.63 9.62 0.47 1.7e-19 Corneal astigmatism; LUSC cis rs2760061 0.784 rs1745414 chr1:228212159 T/A cg02753203 chr1:228287806 NA 0.71 12.42 0.56 2.22e-29 Diastolic blood pressure; LUSC cis rs1018697 1.000 rs7088711 chr10:104559266 A/G cg04362960 chr10:104952993 NT5C2 -0.46 -6.4 -0.33 5.25e-10 Colorectal adenoma (advanced); LUSC cis rs12049351 0.774 rs36021190 chr1:229697863 T/C cg11742688 chr1:229674241 ABCB10 -0.4 -5.81 -0.3 1.43e-8 Circulating myeloperoxidase levels (plasma); LUSC cis rs1790761 0.692 rs674783 chr11:67339076 C/T cg14500267 chr11:67383377 NA 0.34 6.51 0.34 2.75e-10 Mean corpuscular volume; LUSC cis rs10875595 0.836 rs10067231 chr5:140673429 C/T cg24830062 chr5:140700576 TAF7 -0.51 -6.24 -0.32 1.31e-9 Pulmonary function decline; LUSC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.8 -0.6 1.42e-34 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.662 rs35472251 chr8:10246669 A/G cg06636001 chr8:8085503 FLJ10661 0.54 7.3 0.37 2.12e-12 Neuroticism; LUSC trans rs853679 0.517 rs9295761 chr6:28147987 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.16e-9 Depression; LUSC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg20283391 chr11:68216788 NA 0.55 8.15 0.41 7.52e-15 Total body bone mineral density; LUSC cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.11 0.48 3.89e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1062746 0.520 rs17770965 chr16:87328597 G/A cg02258303 chr16:87377426 FBXO31 -0.53 -7.88 -0.4 4.52e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs7216064 0.953 rs8073510 chr17:65839210 A/G cg12091567 chr17:66097778 LOC651250 -0.75 -9.36 -0.46 1.21e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs1451375 1.000 rs4452748 chr7:50625056 A/C cg18232548 chr7:50535776 DDC -0.5 -7.56 -0.38 3.85e-13 Malaria; LUSC cis rs9467773 1.000 rs6940188 chr6:26562029 G/C cg09904177 chr6:26538194 HMGN4 0.76 14.17 0.61 5.2e-36 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18497504 chr21:38639897 DSCR3 0.55 7.37 0.37 1.36e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg20503657 chr10:835505 NA 0.73 9.19 0.45 4.2e-18 Eosinophil percentage of granulocytes; LUSC cis rs7954584 0.551 rs1169072 chr12:122401501 C/T cg10207240 chr12:122356781 WDR66 -0.4 -5.8 -0.3 1.52e-8 Mean corpuscular volume; LUSC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg26119090 chr2:26468346 HADHA;HADHB 0.79 9.31 0.45 1.73e-18 Gut microbiome composition (summer); LUSC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.63e-8 Depression; LUSC cis rs7524258 0.903 rs4908450 chr1:7292756 T/C cg07173049 chr1:7289937 CAMTA1 0.37 7.64 0.39 2.38e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7577696 0.524 rs212696 chr2:32441685 A/G cg02381751 chr2:32503542 YIPF4 0.53 6.82 0.35 4.3e-11 Inflammatory biomarkers; LUSC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11644478 chr21:40555479 PSMG1 0.63 9.84 0.47 3.12e-20 Menarche (age at onset); LUSC cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs16910800 0.731 rs1065631 chr11:23186810 T/C cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs7131987 0.650 rs67146951 chr12:29450553 C/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.57 -0.34 1.99e-10 QT interval; LUSC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg14019146 chr3:50243930 SLC38A3 0.3 6.68 0.34 1.01e-10 Intelligence (multi-trait analysis); LUSC cis rs1568889 0.938 rs11601602 chr11:28233768 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 8.76 0.43 9.72e-17 Bipolar disorder; LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg22868518 chr11:507468 RNH1 -0.61 -5.98 -0.31 5.79e-9 Body mass index; LUSC cis rs5769707 0.681 rs4824068 chr22:50024801 G/A cg05373962 chr22:49881684 NA -0.41 -8.77 -0.43 9.37e-17 Monocyte count;Monocyte percentage of white cells; LUSC trans rs9467711 0.659 rs72845428 chr6:26550144 C/T cg06606381 chr12:133084897 FBRSL1 -0.75 -6.68 -0.34 1.03e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.85 -12.31 -0.56 5.48e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8060686 0.641 rs76053508 chr16:68243054 A/T cg27539214 chr16:67997921 SLC12A4 -0.56 -7.19 -0.37 4.36e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs7954584 0.626 rs10840637 chr12:122427310 A/G cg22618164 chr12:122356400 WDR66 0.58 8.53 0.42 5.02e-16 Mean corpuscular volume; LUSC cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg21427119 chr20:30132790 HM13 -0.37 -5.79 -0.3 1.62e-8 Mean corpuscular hemoglobin; LUSC cis rs2014572 0.904 rs10412465 chr19:57753931 T/C cg24459738 chr19:57751996 ZNF805 -0.54 -8.01 -0.4 1.88e-14 Hyperactive-impulsive symptoms; LUSC cis rs9309473 0.615 rs74523560 chr2:73764185 C/T cg20560298 chr2:73613845 ALMS1 -0.57 -6.76 -0.35 6.3e-11 Metabolite levels; LUSC cis rs9807989 0.801 rs4851566 chr2:102972799 G/C cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.74e-9 Asthma; LUSC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg24829409 chr8:58192753 C8orf71 -0.56 -6.08 -0.32 3.35e-9 Developmental language disorder (linguistic errors); LUSC trans rs724744 0.712 rs1205939 chr6:22357130 T/C cg13807341 chr11:118445984 ARCN1 -0.36 -6.05 -0.31 3.89e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs453301 0.686 rs11785634 chr8:8892597 G/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.8 -0.39 7.98e-14 Joint mobility (Beighton score); LUSC cis rs4319547 0.697 rs7974262 chr12:122896385 C/T cg23029597 chr12:123009494 RSRC2 0.73 9.25 0.45 2.65e-18 Body mass index; LUSC cis rs7615952 0.605 rs11708269 chr3:125332150 C/T cg05084668 chr3:125655381 ALG1L -0.7 -7.86 -0.39 5.44e-14 Blood pressure (smoking interaction); LUSC trans rs62055045 0.929 rs6499512 chr16:71403235 C/T cg05226518 chr14:54908796 CNIH -0.51 -6.12 -0.32 2.6e-9 Schizophrenia; LUSC trans rs2898290 0.622 rs978804 chr8:11343673 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.36 -0.33 6.73e-10 Systolic blood pressure; LUSC trans rs2243480 1.000 rs6949812 chr7:65387101 G/A cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg22800045 chr5:56110881 MAP3K1 0.64 8.62 0.43 2.66e-16 Initial pursuit acceleration; LUSC cis rs7180079 1.000 rs2062248 chr15:64672319 C/T cg08069370 chr15:64387884 SNX1 0.63 6.19 0.32 1.77e-9 Monocyte count; LUSC cis rs500891 0.525 rs7753311 chr6:84095038 T/C cg08257003 chr6:84140564 ME1 0.35 8.51 0.42 5.77e-16 Platelet-derived growth factor BB levels; LUSC cis rs939574 0.790 rs72955447 chr2:220098287 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.9 6.36 0.33 6.62e-10 Platelet distribution width; LUSC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg18305652 chr10:134549665 INPP5A 0.44 6.66 0.34 1.1e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg21918786 chr6:109611834 NA -0.37 -6.38 -0.33 6.02e-10 Reticulocyte fraction of red cells; LUSC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg01283332 chr5:1856932 NA -0.33 -6.34 -0.33 7.54e-10 Cardiovascular disease risk factors; LUSC cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg03146154 chr1:46216737 IPP -0.51 -7.46 -0.38 7.41e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7903847 0.619 rs10882912 chr10:99138077 C/T cg08345082 chr10:99160200 RRP12 -0.37 -7.56 -0.38 3.89e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs2289583 0.642 rs7162941 chr15:75385622 C/T cg14664628 chr15:75095509 CSK 0.44 6.23 0.32 1.4e-9 Systemic lupus erythematosus; LUSC cis rs17345786 0.906 rs58835747 chr3:101243634 T/C cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.43 5.82 0.3 1.37e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg01579765 chr21:45077557 HSF2BP 0.53 11.04 0.52 2.3e-24 Mean corpuscular volume; LUSC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg22800045 chr5:56110881 MAP3K1 0.43 6.08 0.32 3.29e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg17143192 chr8:8559678 CLDN23 0.64 9.33 0.45 1.54e-18 Obesity-related traits; LUSC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg26659404 chr1:25747437 RHCE -0.28 -5.75 -0.3 1.98e-8 Erythrocyte sedimentation rate; LUSC trans rs4596713 0.538 rs10781440 chr9:71762766 A/G cg25283916 chr1:242222868 NA 0.31 6.36 0.33 6.68e-10 Headache; LUSC cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.31e-41 Bladder cancer; LUSC cis rs9905704 0.831 rs12939500 chr17:56848677 T/C cg12560992 chr17:57184187 TRIM37 0.56 8.04 0.4 1.57e-14 Testicular germ cell tumor; LUSC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg09509183 chr1:209979624 IRF6 0.45 5.91 0.31 8.57e-9 Cleft lip with or without cleft palate; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.46 0.53 7.26e-26 Menopause (age at onset); LUSC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg03233332 chr7:66118400 NA 0.41 5.95 0.31 6.8e-9 Aortic root size; LUSC cis rs11098499 1.000 rs6849889 chr4:120186348 A/C cg24375607 chr4:120327624 NA 0.74 11.08 0.52 1.64e-24 Corneal astigmatism; LUSC cis rs4660306 0.961 rs12145526 chr1:45969036 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.22 -0.37 3.47e-12 Homocysteine levels; LUSC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg18252515 chr7:66147081 NA 1.2 13.62 0.6 6.4e-34 Diabetic kidney disease; LUSC trans rs72674100 1.000 rs28392183 chr4:97949977 C/T cg16405019 chr1:18959625 PAX7 -0.56 -6.05 -0.31 3.87e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs459571 0.839 rs10993895 chr9:136887726 C/T cg01294253 chr9:136912663 BRD3 -0.34 -6.21 -0.32 1.56e-9 Platelet distribution width; LUSC cis rs7267979 0.868 rs6138553 chr20:25239233 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.38 0.67 1.16e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5753037 0.702 rs140100 chr22:30128240 C/T cg11564601 chr22:30592435 NA 0.33 5.93 0.31 7.51e-9 Type 1 diabetes; LUSC cis rs17401966 0.838 rs946501 chr1:10309580 C/G cg19773385 chr1:10388646 KIF1B -0.51 -8.87 -0.44 4.44e-17 Hepatocellular carcinoma; LUSC trans rs17685 0.535 rs6953065 chr7:75601169 A/G cg19862616 chr7:65841803 NCRNA00174 -0.46 -6.23 -0.32 1.4e-9 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs17253792 0.822 rs76192881 chr14:56034654 C/T cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13580321 chr1:93645478 TMED5;CCDC18 -0.4 -5.98 -0.31 5.65e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs561341 0.740 rs11080174 chr17:30208521 C/A cg13647721 chr17:30228624 UTP6 -0.69 -8.0 -0.4 2.05e-14 Hip circumference adjusted for BMI; LUSC cis rs59104589 0.617 rs56390510 chr2:242274489 G/C cg14842376 chr2:242211374 HDLBP 0.53 6.06 0.31 3.69e-9 Fibrinogen levels; LUSC cis rs672059 1.000 rs559476 chr1:183160704 T/C ch.1.3577855R chr1:183094577 LAMC1 0.55 8.06 0.4 1.37e-14 Hypertriglyceridemia; LUSC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg04121214 chr22:50244548 NA -0.34 -5.74 -0.3 2.14e-8 Schizophrenia; LUSC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.92 0.58 3.13e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs477692 1.000 rs577227 chr10:131404528 C/T cg11019008 chr10:131425282 MGMT 0.44 6.54 0.34 2.28e-10 Response to temozolomide; LUSC cis rs9815354 0.556 rs56201224 chr3:42004427 A/C cg03022575 chr3:42003672 ULK4 0.81 8.53 0.42 5.02e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs1908814 0.516 rs60176945 chr8:11796674 T/C cg08975724 chr8:8085496 FLJ10661 0.47 6.66 0.34 1.16e-10 Neuroticism; LUSC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.29e-12 Developmental language disorder (linguistic errors); LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg12016809 chr21:47604291 C21orf56 -0.47 -7.02 -0.36 1.27e-11 Testicular germ cell tumor; LUSC cis rs7923609 0.871 rs12245149 chr10:65321147 C/A cg01631684 chr10:65280961 REEP3 0.41 6.1 0.32 2.96e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9807989 0.507 rs7584093 chr2:102997721 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.27e-12 Asthma; LUSC trans rs61931739 0.500 rs7979240 chr12:34509026 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.35e-22 Morning vs. evening chronotype; LUSC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg21435336 chr19:17392852 ANKLE1 -0.47 -6.22 -0.32 1.52e-9 Systemic lupus erythematosus; LUSC cis rs2249625 0.545 rs55681410 chr6:72877859 G/A cg18830697 chr6:72922368 RIMS1 0.37 7.4 0.38 1.14e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg14092988 chr3:52407081 DNAH1 0.31 5.93 0.31 7.63e-9 Bipolar disorder; LUSC cis rs7760535 0.930 rs10872069 chr6:111861726 A/C cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.59 -0.34 1.74e-10 Metabolic traits; LUSC cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.43 0.33 4.44e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC cis rs4891159 0.790 rs72975930 chr18:74144645 G/A cg24786174 chr18:74118243 ZNF516 -0.83 -15.5 -0.65 3.3e-41 Longevity; LUSC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg23630131 chr7:65973040 NA 0.21 5.77 0.3 1.83e-8 Aortic root size; LUSC cis rs9653442 0.622 rs11685341 chr2:100636757 A/G cg07810366 chr2:100720526 AFF3 0.37 6.1 0.32 2.92e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs59918340 0.764 rs3824234 chr8:142229370 T/C cg23750338 chr8:142222470 SLC45A4 0.58 11.29 0.53 2.93e-25 Immature fraction of reticulocytes; LUSC cis rs10489202 0.608 rs6659593 chr1:168072152 A/T cg24449463 chr1:168025552 DCAF6 -0.64 -9.75 -0.47 6.22e-20 Schizophrenia; LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.47 -0.42 8.09e-16 Gut microbiome composition (summer); LUSC trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg03929089 chr4:120376271 NA 0.72 8.07 0.4 1.3e-14 Axial length; LUSC cis rs2652834 0.851 rs1007076 chr15:63413371 T/C cg05507819 chr15:63340323 TPM1 0.44 5.72 0.3 2.35e-8 HDL cholesterol; LUSC cis rs11122272 0.701 rs971533 chr1:231522097 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7215564 0.908 rs2316067 chr17:78659720 C/T cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs10465746 0.725 rs4907188 chr1:84361608 C/T cg10977910 chr1:84465055 TTLL7 0.52 7.45 0.38 7.96e-13 Obesity-related traits; LUSC cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg23711669 chr6:146136114 FBXO30 0.86 15.46 0.65 4.91e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs12725198 0.507 rs41393951 chr1:16053493 C/T cg18133145 chr1:16060689 PLEKHM2 -0.44 -5.75 -0.3 2.02e-8 Cardiac Troponin-T levels; LUSC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg18876405 chr7:65276391 NA 0.54 8.23 0.41 4.27e-15 Aortic root size; LUSC trans rs7939886 0.844 rs7106504 chr11:55932827 C/T cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC cis rs2282802 0.635 rs269767 chr5:139536922 A/G cg26211634 chr5:139558579 C5orf32 0.39 7.15 0.36 5.59e-12 Intelligence (multi-trait analysis); LUSC cis rs7178572 0.633 rs12907746 chr15:77843326 A/G cg22256960 chr15:77711686 NA -0.47 -7.0 -0.36 1.37e-11 Type 2 diabetes; LUSC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg14092988 chr3:52407081 DNAH1 0.31 6.12 0.32 2.57e-9 Bipolar disorder; LUSC cis rs1448094 0.872 rs10863147 chr12:86408441 G/C cg02569458 chr12:86230093 RASSF9 0.39 6.32 0.33 8.23e-10 Major depressive disorder; LUSC cis rs67366981 0.778 rs3952319 chr14:77684379 A/T cg22824376 chr14:77648248 TMEM63C 0.91 9.38 0.46 1.02e-18 Obsessive-compulsive symptoms; LUSC cis rs13064411 0.696 rs6799610 chr3:113248748 A/C cg18753928 chr3:113234510 CCDC52 0.48 7.48 0.38 6.49e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg07828340 chr4:882639 GAK 1.07 11.42 0.53 1.01e-25 Intelligence (multi-trait analysis); LUSC trans rs4718428 0.672 rs4718412 chr7:66286867 C/T cg18876405 chr7:65276391 NA -0.45 -6.03 -0.31 4.25e-9 Corneal structure; LUSC cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.69 -0.34 9.68e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg24399712 chr22:39784796 NA -0.64 -11.4 -0.53 1.19e-25 Intelligence (multi-trait analysis); LUSC cis rs1003719 0.628 rs2835635 chr21:38528866 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -9.27 -0.45 2.42e-18 Eye color traits; LUSC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg04414720 chr1:150670196 GOLPH3L 0.46 7.41 0.38 1.03e-12 Melanoma; LUSC trans rs12188164 0.965 rs72717435 chr5:448202 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC trans rs6951245 0.935 rs76525951 chr7:1096013 C/T cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg06873352 chr17:61820015 STRADA 0.57 8.86 0.44 5.01e-17 Height; LUSC cis rs741677 0.702 rs9893847 chr17:489043 C/G cg15660573 chr17:549704 VPS53 -0.52 -8.21 -0.41 4.91e-15 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); LUSC cis rs1113500 0.933 rs12132785 chr1:108633083 A/T cg11967332 chr1:108735228 SLC25A24 0.38 5.78 0.3 1.75e-8 Growth-regulated protein alpha levels; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg11645453 chr3:52864694 ITIH4 0.3 6.89 0.35 2.86e-11 Electroencephalogram traits; LUSC cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.17 0.55 1.86e-28 Motion sickness; LUSC trans rs11082098 0.702 rs4799488 chr18:36240112 A/G cg08128007 chr1:839435 NA -0.65 -6.41 -0.33 4.88e-10 Smooth-surface caries;Pit-and-Fissure caries; LUSC cis rs1728785 1.000 rs12918861 chr16:68566508 G/A cg02508848 chr16:68573721 ZFP90 -0.42 -5.72 -0.3 2.31e-8 Ulcerative colitis; LUSC cis rs9814567 1.000 rs2177601 chr3:134245434 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11055008 0.935 rs10845601 chr12:12820134 A/G cg09462578 chr12:12878428 APOLD1 0.5 7.43 0.38 8.93e-13 Pulse pressure; LUSC cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -5.84 -0.3 1.22e-8 Height; LUSC cis rs7927592 0.513 rs608343 chr11:68196830 T/C cg16797656 chr11:68205561 LRP5 0.46 8.26 0.41 3.43e-15 Total body bone mineral density; LUSC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.5 0.75 4.96e-61 Homoarginine levels; LUSC cis rs1728785 1.000 rs1170445 chr16:68573064 G/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg05626013 chr10:68685252 CTNNA3;LRRTM3 0.35 6.21 0.32 1.54e-9 Tuberculosis; LUSC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg04998671 chr14:104000505 TRMT61A -0.42 -5.94 -0.31 7.19e-9 Reticulocyte count; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg01719780 chr1:157126054 NA 0.38 6.23 0.32 1.43e-9 Mosquito bite size; LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.08 15.23 0.64 3.67e-40 Gut microbiome composition (summer); LUSC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.3 -0.33 9.56e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs765787 0.530 rs2668751 chr15:45517293 T/C cg24006582 chr15:45444508 DUOX1 -0.62 -9.14 -0.45 6.18e-18 Uric acid levels; LUSC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg21699342 chr2:239360505 ASB1 0.55 10.46 0.5 2.51e-22 Multiple system atrophy; LUSC cis rs72634258 1.000 rs72634258 chr1:8150638 T/C cg26816564 chr1:7831052 VAMP3 0.48 5.78 0.3 1.71e-8 Inflammatory bowel disease; LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg18266620 chr1:110882148 RBM15 -0.4 -6.04 -0.31 4.09e-9 QT interval (ambient particulate matter interaction); LUSC cis rs4319547 0.656 rs6488951 chr12:122873928 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.42 -0.42 1.12e-15 Body mass index; LUSC cis rs12760731 0.565 rs11585355 chr1:178181219 T/G cg00404053 chr1:178313656 RASAL2 0.68 6.89 0.35 2.73e-11 Obesity-related traits; LUSC cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg09184832 chr6:79620586 NA -0.36 -5.72 -0.3 2.41e-8 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.647 rs12903586 chr15:77168240 G/A cg23625390 chr15:77176239 SCAPER -0.64 -9.93 -0.48 1.57e-20 Blood metabolite levels; LUSC cis rs3789045 0.560 rs2271424 chr1:204403311 A/G cg17419461 chr1:204415978 PIK3C2B -0.48 -5.85 -0.3 1.19e-8 Educational attainment (college completion); LUSC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -10.0 -0.48 9.34e-21 Developmental language disorder (linguistic errors); LUSC cis rs9611519 0.754 rs4820435 chr22:41652846 G/T cg13813247 chr22:41461852 NA -0.31 -5.74 -0.3 2.16e-8 Neuroticism; LUSC cis rs10489202 0.608 rs7553238 chr1:168076768 G/A cg24449463 chr1:168025552 DCAF6 -0.64 -9.52 -0.46 3.62e-19 Schizophrenia; LUSC cis rs4930103 0.935 rs2075744 chr11:2018449 A/G cg06197492 chr11:2016605 H19 0.42 6.85 0.35 3.5e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs10979 1.000 rs9496678 chr6:143896664 C/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC trans rs76156646 0.623 rs9464052 chr6:54173889 A/G cg05371498 chr16:10989530 CIITA 0.58 5.98 0.31 5.67e-9 Hepatitis B; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg21280719 chr6:42927975 GNMT -0.29 -7.0 -0.36 1.38e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs5769707 0.632 rs1476037 chr22:49991377 G/A cg05373962 chr22:49881684 NA -0.39 -8.48 -0.42 7.27e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg07362569 chr17:61921086 SMARCD2 0.38 7.76 0.39 1.02e-13 Prudent dietary pattern; LUSC cis rs977987 0.778 rs34222958 chr16:75398252 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.95 -0.36 1.94e-11 Dupuytren's disease; LUSC cis rs4356932 1.000 rs4241580 chr4:76956188 T/C cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs911555 0.723 rs4906320 chr14:103876925 T/C cg12935359 chr14:103987150 CKB 0.67 10.68 0.5 4.38e-23 Intelligence (multi-trait analysis); LUSC cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg03146154 chr1:46216737 IPP 0.52 7.57 0.38 3.58e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8114671 0.967 rs6088734 chr20:33745046 A/T cg07148914 chr20:33460835 GGT7 0.46 6.92 0.35 2.33e-11 Height; LUSC cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg25174290 chr11:3078921 CARS 0.6 9.77 0.47 5.36e-20 Longevity; LUSC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg26314531 chr2:26401878 FAM59B 0.63 8.67 0.43 1.95e-16 Gut microbiome composition (summer); LUSC cis rs11247915 0.540 rs11582416 chr1:26677721 A/G cg15628303 chr1:26608928 UBXN11 -0.38 -6.03 -0.31 4.29e-9 Obesity-related traits; LUSC cis rs2290159 0.800 rs5746195 chr3:12653800 A/G cg23032965 chr3:12705835 RAF1 0.74 8.95 0.44 2.58e-17 Cholesterol, total; LUSC trans rs853679 0.607 rs36101351 chr6:27943369 C/T cg09904177 chr6:26538194 HMGN4 -0.78 -5.94 -0.31 6.98e-9 Depression; LUSC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.88 0.4 4.66e-14 Total body bone mineral density; LUSC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 8.94 0.44 2.64e-17 Axial length; LUSC cis rs765787 0.530 rs1706832 chr15:45517173 C/T cg25801113 chr15:45476975 SHF 0.34 7.18 0.37 4.62e-12 Uric acid levels; LUSC trans rs61931739 0.929 rs2389274 chr12:34075149 T/C cg13010199 chr12:38710504 ALG10B -0.46 -7.4 -0.38 1.11e-12 Morning vs. evening chronotype; LUSC trans rs61931739 0.517 rs2636074 chr12:34064056 C/T cg26384229 chr12:38710491 ALG10B 0.7 11.03 0.52 2.5e-24 Morning vs. evening chronotype; LUSC cis rs7772486 0.869 rs2777473 chr6:146301494 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.27 0.37 2.49e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4988958 0.584 rs7559845 chr2:103046214 T/G cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.92e-12 Asthma (childhood onset); LUSC cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg08754478 chr10:133766260 PPP2R2D -0.62 -7.82 -0.39 6.87e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25976786 chr12:53662079 ESPL1 0.36 6.29 0.33 9.93e-10 Triglycerides; LUSC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs427394 0.664 rs274696 chr5:6732213 A/C cg25011763 chr5:6727354 POLS -0.36 -6.18 -0.32 1.83e-9 Menopause (age at onset); LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg25767906 chr1:53392781 SCP2 0.48 8.7 0.43 1.54e-16 Monocyte count; LUSC cis rs10876993 0.928 rs1628552 chr12:58082142 C/T cg15848620 chr12:58087721 OS9 -0.56 -8.09 -0.4 1.1e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs9517320 0.534 rs3858778 chr13:99172249 A/C cg07423050 chr13:99094983 FARP1 0.45 7.14 0.36 5.72e-12 Longevity; LUSC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7727544 0.584 rs7714191 chr5:131341541 C/G cg14196790 chr5:131705035 SLC22A5 0.47 7.68 0.39 1.79e-13 Blood metabolite levels; LUSC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg16989086 chr20:62203971 PRIC285 0.44 6.23 0.32 1.38e-9 Glioblastoma; LUSC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.29 0.33 1.02e-9 Menopause (age at onset); LUSC cis rs1355223 1.000 rs11601923 chr11:34764354 C/G cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.79 -0.3 1.64e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs713477 0.617 rs11627405 chr14:55911657 T/C cg13175173 chr14:55914753 NA -0.3 -6.14 -0.32 2.31e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg11905131 chr22:24372483 LOC391322 -0.58 -9.61 -0.47 1.78e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg06627628 chr2:24431161 ITSN2 -0.59 -7.1 -0.36 7.61e-12 Lymphocyte counts; LUSC cis rs394563 0.967 rs447025 chr6:149799128 A/C cg07828024 chr6:149772892 ZC3H12D -0.33 -7.2 -0.37 4.13e-12 Dupuytren's disease; LUSC cis rs10464366 0.560 rs12701692 chr7:39135551 A/G cg15212455 chr7:39170539 POU6F2 0.56 9.23 0.45 3.18e-18 IgG glycosylation; LUSC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg21918786 chr6:109611834 NA -0.39 -6.82 -0.35 4.33e-11 Reticulocyte fraction of red cells; LUSC cis rs6121246 0.909 rs1994250 chr20:30287494 A/G cg13852791 chr20:30311386 BCL2L1 0.88 11.91 0.55 1.72e-27 Mean corpuscular hemoglobin; LUSC cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg01884057 chr2:25150051 NA 0.48 11.42 0.53 1e-25 Body mass index in non-asthmatics; LUSC cis rs61931739 0.534 rs2636072 chr12:34062386 C/T cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.05e-15 Morning vs. evening chronotype; LUSC cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg04990556 chr1:26633338 UBXN11 -0.45 -5.94 -0.31 7.02e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs1160297 0.576 rs1451458 chr2:53088905 G/C cg07782112 chr2:53107842 NA 0.4 6.43 0.33 4.32e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg13010344 chr12:123464640 ARL6IP4 -0.49 -6.77 -0.35 5.93e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs9325144 0.560 rs11183046 chr12:38655270 A/T cg26384229 chr12:38710491 ALG10B -0.66 -10.27 -0.49 1.11e-21 Morning vs. evening chronotype; LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.63 -0.43 2.6e-16 Bipolar disorder; LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg23625390 chr15:77176239 SCAPER -0.46 -7.11 -0.36 7.16e-12 Blood metabolite levels; LUSC cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.74 8.69 0.43 1.71e-16 Schizophrenia; LUSC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg23205692 chr1:25664452 TMEM50A 0.38 5.76 0.3 1.96e-8 Erythrocyte sedimentation rate; LUSC cis rs523522 0.885 rs524735 chr12:121022099 T/C cg12219531 chr12:120966889 COQ5 0.67 9.16 0.45 5.19e-18 High light scatter reticulocyte count; LUSC cis rs7759001 0.857 rs4455661 chr6:27373130 C/T cg18711553 chr6:27366782 ZNF391 -0.4 -5.77 -0.3 1.81e-8 Glomerular filtration rate (creatinine); LUSC cis rs1152591 0.524 rs1255990 chr14:64661523 A/G cg21174375 chr14:64681225 SYNE2 -0.32 -5.79 -0.3 1.65e-8 Atrial fibrillation; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg17465130 chr10:135192054 PAOX 0.47 6.43 0.33 4.52e-10 Cognitive function;Information processing speed; LUSC cis rs6964587 0.692 rs2158138 chr7:91700879 A/G cg17063962 chr7:91808500 NA 0.57 9.41 0.46 8.1e-19 Breast cancer; LUSC cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg01475377 chr6:109611718 NA -0.41 -7.39 -0.37 1.22e-12 Reticulocyte fraction of red cells; LUSC trans rs61931739 0.929 rs7955240 chr12:34066388 G/A cg13010199 chr12:38710504 ALG10B -0.47 -7.43 -0.38 8.88e-13 Morning vs. evening chronotype; LUSC cis rs9616064 0.531 rs9616086 chr22:47050744 G/A cg05621596 chr22:47072043 GRAMD4 -0.54 -8.62 -0.43 2.75e-16 Urate levels in obese individuals; LUSC cis rs929354 0.742 rs7784442 chr7:156934475 G/C cg17757837 chr7:157058334 UBE3C 0.82 12.98 0.58 1.8e-31 Body mass index; LUSC cis rs7089973 0.523 rs34170154 chr10:116740959 C/T cg23260525 chr10:116636907 FAM160B1 0.3 5.79 0.3 1.61e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg08355456 chr11:67383691 NA 0.35 6.59 0.34 1.74e-10 Mean corpuscular volume; LUSC cis rs1372520 0.567 rs2619349 chr4:90746646 G/T cg15133208 chr4:90757351 SNCA -0.53 -8.27 -0.41 3.2e-15 Neuroticism; LUSC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg09796270 chr17:17721594 SREBF1 0.43 7.86 0.4 5.36e-14 Total body bone mineral density; LUSC trans rs13196614 0.756 rs9498110 chr6:148998775 A/C cg01343097 chr1:248284971 OR2M1P 0.39 5.98 0.31 5.86e-9 Migraine; LUSC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg00343986 chr7:65444356 GUSB 0.44 6.72 0.35 7.92e-11 Aortic root size; LUSC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg13319975 chr6:146136371 FBXO30 0.51 7.65 0.39 2.24e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs208520 0.661 rs150263 chr6:66777620 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -17.19 -0.69 6.68e-48 Exhaled nitric oxide output; LUSC cis rs7799006 0.606 rs7792045 chr7:2316852 C/T cg08027265 chr7:2291960 NA -0.58 -10.22 -0.49 1.66e-21 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1595825 0.891 rs7573687 chr2:198893376 A/G cg10547527 chr2:198650123 BOLL -0.52 -6.3 -0.33 9.56e-10 Ulcerative colitis; LUSC cis rs950776 0.593 rs555018 chr15:78879242 G/A cg22563815 chr15:78856949 CHRNA5 -0.26 -6.3 -0.33 9.31e-10 Sudden cardiac arrest; LUSC cis rs6541297 0.887 rs6541295 chr1:230281698 A/G cg05784532 chr1:230284198 GALNT2 0.61 7.62 0.38 2.69e-13 Coronary artery disease; LUSC cis rs477692 0.905 rs489966 chr10:131422115 C/G cg11019008 chr10:131425282 MGMT -0.39 -5.99 -0.31 5.34e-9 Response to temozolomide; LUSC cis rs2011503 0.941 rs76944848 chr19:19417512 C/T cg11584989 chr19:19387371 SF4 0.63 7.04 0.36 1.11e-11 Bipolar disorder; LUSC cis rs6121246 0.559 rs6060933 chr20:30351903 C/T cg13852791 chr20:30311386 BCL2L1 0.93 14.5 0.62 2.8e-37 Mean corpuscular hemoglobin; LUSC cis rs56104184 0.830 rs45589039 chr19:49355385 C/T cg15549821 chr19:49342101 PLEKHA4 -0.9 -10.62 -0.5 6.81e-23 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs9611565 0.729 rs505533 chr22:41864216 A/C cg03806693 chr22:41940476 POLR3H 0.85 12.33 0.56 4.85e-29 Vitiligo; LUSC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg02782426 chr3:40428986 ENTPD3 0.33 6.21 0.32 1.53e-9 Renal cell carcinoma; LUSC trans rs9341835 0.518 rs2622294 chr6:64218316 T/A cg19533977 chr17:57719682 CLTC 0.33 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg12564285 chr5:131593104 PDLIM4 0.34 6.27 0.32 1.09e-9 Blood metabolite levels; LUSC cis rs1577917 0.740 rs7752502 chr6:86410651 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.45 7.21 0.37 3.78e-12 Response to antipsychotic treatment; LUSC trans rs9951602 0.703 rs2959407 chr18:76682915 A/G cg02800362 chr5:177631904 HNRNPAB 0.54 6.31 0.33 8.99e-10 Obesity-related traits; LUSC cis rs7180079 0.544 rs8038016 chr15:64995737 C/T cg08069370 chr15:64387884 SNX1 0.52 5.72 0.3 2.32e-8 Monocyte count; LUSC cis rs116988415 0.584 rs78748209 chr14:65255676 C/T cg25083366 chr14:65239357 SPTB 0.68 6.92 0.35 2.27e-11 Daytime sleep phenotypes; LUSC cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg13535736 chr9:111863775 C9orf5 -0.4 -6.55 -0.34 2.16e-10 Menarche (age at onset); LUSC cis rs2562456 0.755 rs1879234 chr19:21704479 T/G cg00806126 chr19:22604979 ZNF98 0.37 5.73 0.3 2.21e-8 Pain; LUSC cis rs2639990 1.000 rs632157 chr18:72911548 G/A cg18449964 chr18:72917101 ZADH2 0.48 5.77 0.3 1.83e-8 Vascular endothelial growth factor levels; LUSC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg05896524 chr21:47604654 C21orf56 0.43 6.43 0.33 4.51e-10 Testicular germ cell tumor; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 11.24 0.52 4.37e-25 Alzheimer's disease; LUSC cis rs4622329 0.636 rs4764836 chr12:102287703 A/T cg23541617 chr12:102225335 GNPTAB 0.26 6.08 0.32 3.23e-9 Systemic lupus erythematosus; LUSC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg13206674 chr6:150067644 NUP43 0.58 9.29 0.45 2.09e-18 Lung cancer; LUSC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.95 0.36 1.87e-11 Hip circumference adjusted for BMI; LUSC cis rs2479724 0.811 rs6905726 chr6:41750812 T/C cg17623882 chr6:41773611 USP49 0.63 10.39 0.49 4.18e-22 Menarche (age at onset); LUSC cis rs909341 0.710 rs2297433 chr20:62293460 T/C cg16989086 chr20:62203971 PRIC285 -0.53 -7.38 -0.37 1.26e-12 Atopic dermatitis; LUSC cis rs9309473 0.500 rs4852952 chr2:73869907 T/C cg20560298 chr2:73613845 ALMS1 0.42 6.37 0.33 6.27e-10 Metabolite levels; LUSC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg05729581 chr11:3078854 CARS -0.58 -9.04 -0.44 1.27e-17 Longevity; LUSC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg07936489 chr17:37558343 FBXL20 -0.82 -10.36 -0.49 5.48e-22 Glomerular filtration rate (creatinine); LUSC cis rs981844 0.683 rs4696191 chr4:154740668 G/A cg14289246 chr4:154710475 SFRP2 -0.44 -6.13 -0.32 2.5e-9 Response to statins (LDL cholesterol change); LUSC cis rs34779708 0.966 rs12260130 chr10:35467671 C/T cg04310649 chr10:35416472 CREM -0.43 -6.69 -0.34 9.52e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.71 0.47 8.71e-20 Personality dimensions; LUSC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -12.36 -0.56 3.64e-29 Type 2 diabetes; LUSC cis rs10911363 0.573 rs2761580 chr1:183516989 A/T cg09173681 chr1:183549694 NCF2 0.63 11.24 0.52 4.38e-25 Systemic lupus erythematosus; LUSC cis rs7953508 0.636 rs10859535 chr12:93979892 A/G cg18151635 chr12:93972918 NA -0.59 -8.15 -0.41 7.36e-15 Pubertal anthropometrics; LUSC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.86 -0.31 1.12e-8 Life satisfaction; LUSC trans rs804280 0.509 rs4841639 chr8:11796093 A/T cg27411982 chr8:10470053 RP1L1 0.39 6.04 0.31 4.05e-9 Myopia (pathological); LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg07677032 chr17:61819896 STRADA 0.53 8.86 0.44 4.89e-17 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.47e-25 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg23758822 chr17:41437982 NA 1.04 20.0 0.74 4.54e-59 Menopause (age at onset); LUSC cis rs11711311 0.955 rs34048496 chr3:113414121 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.55 0.34 2.24e-10 IgG glycosylation; LUSC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.37 -0.33 6.25e-10 Lung cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01648131 chr19:58838208 ZSCAN22 -0.42 -6.2 -0.32 1.62e-9 Electrocardiographic conduction measures; LUSC cis rs11031096 0.727 rs2268168 chr11:4142069 C/T cg18678763 chr11:4115507 RRM1 -0.53 -7.5 -0.38 5.82e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs7618501 0.538 rs9856572 chr3:50109073 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -9.37 -0.46 1.15e-18 Intelligence (multi-trait analysis); LUSC cis rs524023 0.914 rs7932437 chr11:64373504 T/C cg07220939 chr11:64358617 SLC22A12 -0.22 -5.72 -0.3 2.32e-8 Urate levels in obese individuals; LUSC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg05623727 chr3:50126028 RBM5 -0.33 -6.14 -0.32 2.32e-9 Intelligence (multi-trait analysis); LUSC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.67 0.39 1.87e-13 Bipolar disorder; LUSC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg18827107 chr12:86230957 RASSF9 -0.49 -7.25 -0.37 2.85e-12 Major depressive disorder; LUSC cis rs12579753 0.956 rs7965168 chr12:82184467 C/A cg21231944 chr12:82153410 PPFIA2 -0.4 -5.96 -0.31 6.25e-9 Resting heart rate; LUSC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.55 -0.38 4.28e-13 Alzheimer's disease (late onset); LUSC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg13119609 chr19:45449297 APOC2 0.5 10.17 0.49 2.48e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6545883 0.965 rs7591345 chr2:61729641 T/A cg15711740 chr2:61764176 XPO1 -0.49 -7.71 -0.39 1.47e-13 Tuberculosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05380522 chr12:53473279 SPRYD3 -0.41 -6.35 -0.33 7.08e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1371867 0.555 rs2861348 chr8:101285074 A/G cg00191853 chr8:101177733 SPAG1 -0.37 -6.28 -0.33 1.03e-9 Atrioventricular conduction; LUSC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg17385448 chr1:15911702 AGMAT 0.36 6.18 0.32 1.82e-9 Systolic blood pressure; LUSC cis rs738322 0.577 rs6001034 chr22:38558459 A/G cg25457927 chr22:38595422 NA -0.34 -6.81 -0.35 4.62e-11 Cutaneous nevi; LUSC cis rs3020736 0.500 rs6002616 chr22:42504679 A/G cg05082376 chr22:42548792 NA 0.43 6.59 0.34 1.73e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs7659604 0.540 rs67150579 chr4:122704331 T/A cg19748678 chr4:122722346 EXOSC9 -0.49 -7.29 -0.37 2.25e-12 Type 2 diabetes; LUSC cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.51 0.53 4.8e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13394619 0.605 rs12476152 chr2:11747960 T/C cg07314298 chr2:11723111 GREB1 0.44 7.46 0.38 7.48e-13 Endometriosis; LUSC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg07936489 chr17:37558343 FBXL20 -0.71 -9.87 -0.48 2.41e-20 Glomerular filtration rate (creatinine); LUSC cis rs61863818 0.557 rs7898743 chr10:99153540 T/G cg08345082 chr10:99160200 RRP12 -0.3 -6.26 -0.32 1.21e-9 Monocyte percentage of white cells; LUSC cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg18806716 chr10:30721971 MAP3K8 -0.7 -11.39 -0.53 1.32e-25 Inflammatory bowel disease; LUSC cis rs1729951 0.575 rs747843 chr3:136703130 G/C cg12473912 chr3:136751656 NA 0.4 7.13 0.36 6.2e-12 Neuroticism; LUSC cis rs12681287 0.752 rs7846635 chr8:87304281 G/A cg27223183 chr8:87520930 FAM82B -0.47 -5.9 -0.31 8.75e-9 Caudate activity during reward; LUSC cis rs12908161 0.959 rs12908699 chr15:85240403 G/T cg17507749 chr15:85114479 UBE2QP1 0.56 6.96 0.36 1.8e-11 Schizophrenia; LUSC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.95 0.31 6.74e-9 Personality dimensions; LUSC cis rs6960043 0.782 rs10228456 chr7:15063926 C/T cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg19046167 chr17:80928561 B3GNTL1 0.5 7.01 0.36 1.31e-11 Glycated hemoglobin levels; LUSC cis rs7131987 0.718 rs7976961 chr12:29463088 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.63 -0.34 1.38e-10 QT interval; LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.37e-13 Developmental language disorder (linguistic errors); LUSC cis rs7181230 1.000 rs28587891 chr15:40365106 T/A cg00868766 chr15:40364524 NA 0.34 6.01 0.31 4.94e-9 Dehydroepiandrosterone sulphate levels; LUSC cis rs847577 0.609 rs11768309 chr7:97773812 G/T cg24562669 chr7:97807699 LMTK2 0.47 8.61 0.43 2.86e-16 Breast cancer; LUSC cis rs77972916 0.611 rs10495899 chr2:43602304 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.44 -5.77 -0.3 1.81e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg05347473 chr6:146136440 FBXO30 0.58 10.16 0.49 2.54e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs796364 0.570 rs4673491 chr2:200669108 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.62 6.84 0.35 3.9e-11 Schizophrenia; LUSC cis rs7709377 0.597 rs10051072 chr5:115488499 C/T cg23108291 chr5:115420582 COMMD10 0.41 5.79 0.3 1.59e-8 Metabolite levels (X-11787); LUSC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg06740227 chr12:86229804 RASSF9 -0.36 -5.7 -0.3 2.61e-8 Major depressive disorder; LUSC cis rs1348850 0.958 rs11689550 chr2:178456298 A/G cg22681709 chr2:178499509 PDE11A -0.45 -8.1 -0.41 1.05e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1801251 1.000 rs2675974 chr2:233727071 A/G cg08000102 chr2:233561755 GIGYF2 0.7 11.71 0.54 9.2e-27 Coronary artery disease; LUSC trans rs7395662 0.591 rs10838968 chr11:48595046 A/G cg03929089 chr4:120376271 NA -0.45 -6.11 -0.32 2.81e-9 HDL cholesterol; LUSC cis rs929354 1.000 rs1182391 chr7:157038368 T/C cg05182265 chr7:156933206 UBE3C 0.41 6.16 0.32 2.03e-9 Body mass index; LUSC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg21862992 chr11:68658383 NA -0.47 -7.41 -0.38 1.04e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs600231 0.719 rs7114809 chr11:65251444 A/G cg17120908 chr11:65337727 SSSCA1 -0.53 -9.28 -0.45 2.2e-18 Bone mineral density; LUSC cis rs7937682 0.824 rs11213962 chr11:111506027 G/A cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs7759001 0.857 rs4713086 chr6:27350446 A/T cg18711553 chr6:27366782 ZNF391 0.45 6.43 0.33 4.33e-10 Glomerular filtration rate (creatinine); LUSC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08109568 chr15:31115862 NA -0.59 -8.24 -0.41 3.89e-15 Huntington's disease progression; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06391300 chr11:119600292 PVRL1 0.49 7.51 0.38 5.3e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.0 0.52 3.23e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg20744362 chr22:50050164 C22orf34 0.39 8.1 0.41 1.04e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs921968 0.541 rs3770214 chr2:219508988 C/T cg02176678 chr2:219576539 TTLL4 -0.76 -14.73 -0.63 3.36e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg17179660 chr6:151773299 C6orf211;RMND1 -0.46 -6.73 -0.35 7.2e-11 Menarche (age at onset); LUSC cis rs13315871 0.722 rs3952239 chr3:58312057 G/T cg12435725 chr3:58293450 RPP14 -0.72 -7.38 -0.37 1.3e-12 Cholesterol, total; LUSC cis rs72627509 0.951 rs17087335 chr4:57838583 G/T cg26694713 chr4:57773883 REST 0.49 5.75 0.3 2.04e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg01657329 chr11:68192670 LRP5 -0.44 -6.59 -0.34 1.67e-10 Total body bone mineral density; LUSC cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.88e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4478858 0.684 rs17440445 chr1:31722562 C/T cg00250761 chr1:31883323 NA 0.35 8.41 0.42 1.17e-15 Alcohol dependence; LUSC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg17554472 chr22:41940697 POLR3H -0.46 -5.77 -0.3 1.84e-8 Vitiligo; LUSC trans rs11098499 0.722 rs17595727 chr4:120262074 C/T cg25214090 chr10:38739885 LOC399744 -0.41 -6.28 -0.32 1.03e-9 Corneal astigmatism; LUSC cis rs2901656 0.934 rs2285176 chr1:172421744 G/A cg03748243 chr1:172413542 C1orf105;PIGC 0.29 5.78 0.3 1.75e-8 Red cell distribution width;Platelet distribution width; LUSC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg10360139 chr7:1886902 MAD1L1 -0.45 -7.01 -0.36 1.36e-11 Bipolar disorder and schizophrenia; LUSC cis rs4363385 0.818 rs3806223 chr1:153002646 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC trans rs656319 0.580 rs17690549 chr8:9998538 C/G cg21775007 chr8:11205619 TDH -0.47 -6.55 -0.34 2.18e-10 Myopia (pathological); LUSC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg07636037 chr3:49044803 WDR6 1.03 17.91 0.7 9.02e-51 Parkinson's disease; LUSC cis rs9300255 0.739 rs2337934 chr12:123745359 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.18 -0.32 1.82e-9 Neutrophil percentage of white cells; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.2 0.61 3.82e-36 Platelet count; LUSC cis rs8078723 0.714 rs12940405 chr17:38143768 C/T cg17467752 chr17:38218738 THRA -0.71 -11.39 -0.53 1.31e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg26897989 chr16:1907736 C16orf73 -0.41 -6.44 -0.33 4.06e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg15212455 chr7:39170539 POU6F2 0.62 9.94 0.48 1.4e-20 IgG glycosylation; LUSC trans rs11039798 0.764 rs4357721 chr11:48354907 G/A cg03929089 chr4:120376271 NA -0.65 -6.08 -0.32 3.25e-9 Axial length; LUSC cis rs2404602 0.611 rs2404734 chr15:76936165 T/C cg23625390 chr15:77176239 SCAPER -0.65 -9.87 -0.48 2.59e-20 Blood metabolite levels; LUSC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg10523679 chr1:76189770 ACADM 0.9 14.54 0.62 1.85e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10876993 0.890 rs1585781 chr12:58056701 T/G cg18357645 chr12:58087776 OS9 0.55 8.34 0.42 1.95e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg04450456 chr4:17643702 FAM184B 0.36 6.13 0.32 2.54e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs75804782 0.572 rs72982580 chr2:239447783 A/G cg18131467 chr2:239335373 ASB1 -0.65 -6.01 -0.31 4.81e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs748404 0.660 rs690472 chr15:43764368 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.39 5.65 0.3 3.46e-8 Lung cancer; LUSC cis rs977987 0.835 rs3851733 chr16:75370263 G/C cg04384234 chr16:75411784 CFDP1 -0.45 -7.4 -0.38 1.14e-12 Dupuytren's disease; LUSC trans rs2228479 0.681 rs62052184 chr16:89967217 T/C cg24644049 chr4:85504048 CDS1 0.71 7.2 0.37 3.99e-12 Skin colour saturation; LUSC cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg19628046 chr18:33552617 C18orf21 0.52 6.26 0.32 1.17e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg06713675 chr4:122721982 EXOSC9 -0.7 -12.04 -0.55 5.88e-28 Type 2 diabetes; LUSC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg06544989 chr22:39130855 UNC84B 0.33 5.67 0.3 3.02e-8 Menopause (age at onset); LUSC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg05623727 chr3:50126028 RBM5 -0.33 -6.16 -0.32 2.08e-9 Body mass index; LUSC cis rs4843185 0.576 rs380996 chr16:85728813 A/G cg00168118 chr16:85669675 KIAA0182 -0.4 -6.54 -0.34 2.26e-10 Platelet distribution width; LUSC cis rs7178375 0.607 rs34178381 chr15:31222585 G/C cg03767031 chr15:31195708 MTMR15 0.79 6.41 0.33 5.05e-10 Hypertriglyceridemia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12509435 chr12:94853886 CCDC41;LOC144486 -0.4 -6.41 -0.33 4.94e-10 Electrocardiographic conduction measures; LUSC cis rs80282103 0.867 rs11250242 chr10:1100064 A/C cg08668510 chr10:1095578 IDI1 -0.77 -6.96 -0.36 1.85e-11 Glomerular filtration rate (creatinine); LUSC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg06850241 chr22:41845214 NA 0.33 6.15 0.32 2.25e-9 Vitiligo; LUSC cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg04586622 chr2:25135609 ADCY3 0.42 8.98 0.44 1.97e-17 Body mass index; LUSC cis rs1048238 0.545 rs848199 chr1:16292742 C/T cg21385522 chr1:16154831 NA -0.56 -8.67 -0.43 1.95e-16 Systolic blood pressure; LUSC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg17971929 chr21:40555470 PSMG1 -0.61 -9.93 -0.48 1.58e-20 Cognitive function; LUSC cis rs7166081 0.688 rs12903168 chr15:67680209 T/C cg05925327 chr15:68127851 NA -0.36 -5.82 -0.3 1.41e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg26669825 chr2:232063251 ARMC9 0.4 5.94 0.31 7.04e-9 N-glycan levels; LUSC cis rs11112613 0.595 rs871219 chr12:105938519 C/A cg03607813 chr12:105948248 NA 0.79 11.03 0.52 2.44e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18404041 chr3:52824283 ITIH1 -0.54 -10.39 -0.49 4.23e-22 Electroencephalogram traits; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg02951883 chr7:2050386 MAD1L1 -0.39 -6.78 -0.35 5.51e-11 Bipolar disorder and schizophrenia; LUSC cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.37 -0.33 6.35e-10 Extrinsic epigenetic age acceleration; LUSC cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -7.99 -0.4 2.25e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg16339924 chr4:17578868 LAP3 -0.57 -8.34 -0.42 2.02e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2840044 1.000 rs225251 chr17:33951228 A/C cg05299278 chr17:33885742 SLFN14 0.31 6.29 0.33 9.88e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg03806693 chr22:41940476 POLR3H 1.0 14.41 0.62 6.27e-37 Vitiligo; LUSC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg21918786 chr6:109611834 NA -0.35 -5.9 -0.31 9.12e-9 Reticulocyte fraction of red cells; LUSC cis rs13315871 0.929 rs11720747 chr3:58267833 G/A cg20936604 chr3:58311152 NA -0.76 -6.86 -0.35 3.4e-11 Cholesterol, total; LUSC trans rs6076960 0.629 rs6054008 chr20:6212370 C/T cg21095983 chr6:86352623 SYNCRIP 0.49 7.78 0.39 9.04e-14 Smooth-surface caries; LUSC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg14541582 chr5:601475 NA -0.38 -5.93 -0.31 7.36e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7264396 0.887 rs6060438 chr20:34077403 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.16 -0.32 2.12e-9 Total cholesterol levels; LUSC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.01e-11 Tonsillectomy; LUSC cis rs2839186 0.967 rs4819222 chr21:47707778 G/A cg05896524 chr21:47604654 C21orf56 0.4 5.88 0.31 9.78e-9 Testicular germ cell tumor; LUSC cis rs12594515 1.000 rs8032835 chr15:45997897 C/G cg19682013 chr15:45996608 NA 0.39 5.84 0.3 1.24e-8 Waist circumference;Weight; LUSC trans rs156356 0.811 rs552067 chr20:1823326 C/G cg11287903 chr10:115613834 DCLRE1A;NHLRC2 0.39 6.04 0.31 4.22e-9 Mean platelet volume;Platelet distribution width; LUSC trans rs7980799 0.649 rs2389218 chr12:33680929 C/A cg13010199 chr12:38710504 ALG10B 0.43 6.18 0.32 1.91e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg01475377 chr6:109611718 NA -0.4 -6.92 -0.35 2.34e-11 Reticulocyte fraction of red cells; LUSC cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg06784218 chr1:46089804 CCDC17 -0.57 -11.34 -0.53 1.97e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7937890 0.904 rs7484197 chr11:14283654 C/T cg22961513 chr11:14280813 SPON1 -0.35 -6.04 -0.31 4.03e-9 Mitochondrial DNA levels; LUSC trans rs1005277 0.579 rs2474563 chr10:38375938 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.64 -0.47 1.44e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7043114 0.525 rs6479416 chr9:95053871 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.46 -0.33 3.63e-10 Height; LUSC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg19812747 chr11:111475976 SIK2 -0.55 -8.15 -0.41 7.59e-15 Primary sclerosing cholangitis; LUSC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg02428538 chr16:24856791 SLC5A11 -0.56 -6.27 -0.32 1.12e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs7582180 0.629 rs13031906 chr2:100939524 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.6 -0.43 3.22e-16 Intelligence (multi-trait analysis); LUSC cis rs72781680 0.904 rs72796340 chr2:24143622 T/A cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.47 7.01 0.36 1.35e-11 Personality dimensions; LUSC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg04267008 chr7:1944627 MAD1L1 -0.49 -7.18 -0.37 4.67e-12 Schizophrenia; LUSC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg13319975 chr6:146136371 FBXO30 0.51 7.75 0.39 1.15e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27103680 chr2:86423081 IMMT 0.42 6.14 0.32 2.39e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg25767906 chr1:53392781 SCP2 -0.51 -9.21 -0.45 3.7e-18 Monocyte count; LUSC cis rs1564271 0.528 rs2489589 chr10:26983095 A/G cg13837822 chr10:26931731 LOC731789 0.45 9.72 0.47 7.77e-20 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs11971779 0.648 rs10085708 chr7:139110954 A/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs11997175 0.967 rs60586868 chr8:33776585 A/G ch.8.33884649F chr8:33765107 NA 0.5 7.82 0.39 7.15e-14 Body mass index; LUSC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.38 -0.33 5.87e-10 Lung cancer; LUSC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg08975724 chr8:8085496 FLJ10661 0.46 6.77 0.35 5.67e-11 Mood instability; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.24 0.41 3.92e-15 Prudent dietary pattern; LUSC cis rs55665837 1.000 rs12295888 chr11:14450531 T/C cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg01802117 chr1:53393560 SCP2 -0.38 -6.42 -0.33 4.81e-10 Monocyte count; LUSC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.89 -0.4 4.42e-14 Joint mobility (Beighton score); LUSC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg02569458 chr12:86230093 RASSF9 0.59 9.95 0.48 1.36e-20 Major depressive disorder; LUSC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg13607699 chr17:42295918 UBTF 0.49 7.63 0.39 2.41e-13 Total body bone mineral density; LUSC trans rs3733585 0.726 rs4306953 chr4:9955776 G/A cg26043149 chr18:55253948 FECH -0.45 -6.91 -0.35 2.52e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11644478 chr21:40555479 PSMG1 0.95 19.28 0.73 3.26e-56 Cognitive function; LUSC cis rs1997103 1.000 rs6968966 chr7:55411356 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2729354 0.953 rs2848625 chr11:57330650 G/C cg24343310 chr11:57249947 NA 0.37 6.65 0.34 1.17e-10 Blood protein levels; LUSC cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.91 -12.0 -0.55 7.85e-28 Chronic sinus infection; LUSC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg21475434 chr5:93447410 FAM172A 0.82 10.15 0.49 2.79e-21 Diabetic retinopathy; LUSC cis rs3812762 0.879 rs4929934 chr11:8777789 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.38 6.65 0.34 1.17e-10 Hypospadias; LUSC cis rs2361718 0.631 rs4889989 chr17:78151860 C/G cg27427491 chr17:78079615 GAA 0.35 6.4 0.33 5.15e-10 Yeast infection; LUSC cis rs12477438 0.765 rs17708262 chr2:99696313 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.79 -0.51 1.67e-23 Chronic sinus infection; LUSC cis rs7255045 0.788 rs4804737 chr19:12947938 C/T cg21491176 chr19:12958399 MAST1 0.33 5.81 0.3 1.44e-8 Mean corpuscular volume; LUSC cis rs7980687 0.628 rs2851443 chr12:123694250 C/T cg00376283 chr12:123451042 ABCB9 0.68 9.69 0.47 9.85e-20 Height;Educational attainment;Head circumference (infant); LUSC trans rs459571 0.883 rs2520096 chr9:136919416 A/G cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.41 -5.99 -0.31 5.45e-9 Platelet distribution width; LUSC cis rs3772130 0.923 rs13434284 chr3:121482842 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.13 0.48 3.38e-21 Cognitive performance; LUSC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg12641515 chr19:46296257 DMWD 0.48 7.11 0.36 7.23e-12 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05274755 chr14:33408401 NPAS3 0.55 7.9 0.4 3.95e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg07148914 chr20:33460835 GGT7 0.53 8.16 0.41 7.08e-15 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21376831 chr17:40428526 STAT5B -0.55 -6.59 -0.34 1.76e-10 Bipolar disorder and schizophrenia; LUSC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg23758822 chr17:41437982 NA -1.03 -20.67 -0.75 1.02e-61 Menopause (age at onset); LUSC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg23590916 chr17:43697445 MGC57346 0.68 8.79 0.43 8.21e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs9693857 0.553 rs10100760 chr8:9370559 C/T cg15556689 chr8:8085844 FLJ10661 -0.41 -6.19 -0.32 1.72e-9 Systolic blood pressure; LUSC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg02782426 chr3:40428986 ENTPD3 0.38 6.97 0.36 1.7e-11 Renal cell carcinoma; LUSC trans rs9951602 0.512 rs9946120 chr18:76654548 A/T cg02800362 chr5:177631904 HNRNPAB 0.88 13.05 0.58 9.85e-32 Obesity-related traits; LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -5.87 -0.31 1.05e-8 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg19717773 chr7:2847554 GNA12 -0.36 -5.78 -0.3 1.7e-8 Height; LUSC cis rs997295 0.638 rs11854197 chr15:67977384 A/G cg08079166 chr15:68083412 MAP2K5 -0.33 -6.56 -0.34 2.06e-10 Motion sickness; LUSC cis rs2797160 0.967 rs28629380 chr6:126004197 A/G cg05901451 chr6:126070800 HEY2 -0.55 -8.05 -0.4 1.5e-14 Endometrial cancer; LUSC cis rs6430585 0.528 rs586964 chr2:136652491 G/A cg07169764 chr2:136633963 MCM6 1.18 17.44 0.69 6.88e-49 Corneal structure; LUSC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs7539409 0.651 rs979757 chr1:84296605 T/C cg10977910 chr1:84465055 TTLL7 0.71 7.54 0.38 4.45e-13 Alzheimer's disease; LUSC cis rs977987 0.806 rs4887823 chr16:75433074 T/A cg03315344 chr16:75512273 CHST6 0.48 9.12 0.45 7.13e-18 Dupuytren's disease; LUSC cis rs778371 0.722 rs1996342 chr2:233805499 A/G cg08000102 chr2:233561755 GIGYF2 0.51 7.07 0.36 9.3e-12 Schizophrenia; LUSC cis rs7818345 0.967 rs6999786 chr8:19277817 G/A cg11303988 chr8:19266685 CSGALNACT1 0.38 7.19 0.37 4.23e-12 Language performance in older adults (adjusted for episodic memory); LUSC trans rs225245 0.755 rs226441 chr17:34033072 C/T cg19694781 chr19:47549865 TMEM160 -0.38 -6.09 -0.32 3.13e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7267979 0.934 rs6037085 chr20:25305202 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.71e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7246657 0.943 rs10417844 chr19:37837587 C/T cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg16743903 chr16:89593216 SPG7 -0.38 -5.97 -0.31 5.97e-9 Multiple myeloma (IgH translocation); LUSC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg22535103 chr8:58192502 C8orf71 -0.79 -9.59 -0.46 2.13e-19 Developmental language disorder (linguistic errors); LUSC cis rs3857536 0.741 rs9363556 chr6:66934399 T/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -9.34 -0.45 1.44e-18 Monocyte percentage of white cells; LUSC cis rs10504073 0.647 rs6997703 chr8:49998364 T/C cg00325661 chr8:49890786 NA 0.62 9.89 0.48 2.09e-20 Blood metabolite ratios; LUSC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.95 0.31 6.7e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg16339924 chr4:17578868 LAP3 -0.51 -7.35 -0.37 1.58e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7937682 0.889 rs559482 chr11:111497902 G/A cg19812747 chr11:111475976 SIK2 -0.53 -7.42 -0.38 9.6e-13 Primary sclerosing cholangitis; LUSC trans rs17039065 1.000 rs72889383 chr4:109391962 C/T cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.24e-10 Gut microbiome composition (summer); LUSC cis rs10791323 0.581 rs2723608 chr11:133710149 A/G cg15485101 chr11:133734466 NA 0.4 7.24 0.37 3.03e-12 Childhood ear infection; LUSC trans rs2490361 1.000 rs2485595 chr1:237326756 G/A cg15653282 chr18:11689218 GNAL 0.39 6.07 0.32 3.55e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs3540 0.533 rs2352601 chr15:91053125 G/A cg10434728 chr15:90938212 IQGAP1 -0.44 -8.84 -0.44 5.4e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg26384229 chr12:38710491 ALG10B 0.89 15.05 0.64 2.03e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs73198271 0.515 rs76224322 chr8:8635841 C/G cg01851573 chr8:8652454 MFHAS1 0.58 6.53 0.34 2.49e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs721399 0.539 rs2410561 chr8:18266774 G/A cg18736775 chr8:18248649 NAT2 -0.6 -7.09 -0.36 7.9e-12 Blood metabolite levels; LUSC cis rs1065852 0.526 rs9611700 chr22:42401514 C/T cg22189786 chr22:42395067 WBP2NL 0.43 5.75 0.3 2.06e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs6831352 0.879 rs1984364 chr4:100070783 A/C cg12011299 chr4:100065546 ADH4 -0.72 -10.43 -0.5 3.12e-22 Alcohol dependence; LUSC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg04546413 chr19:29218101 NA 0.71 11.42 0.53 1.03e-25 Methadone dose in opioid dependence; LUSC cis rs9326248 1.000 rs7107152 chr11:117056080 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.45 -5.88 -0.31 9.79e-9 Blood protein levels; LUSC cis rs7312933 0.558 rs11181466 chr12:42765181 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.95 0.36 1.88e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg14092988 chr3:52407081 DNAH1 0.31 5.96 0.31 6.35e-9 Bipolar disorder; LUSC cis rs6541297 1.000 rs6686680 chr1:230280522 T/C cg05784532 chr1:230284198 GALNT2 0.54 8.04 0.4 1.57e-14 Coronary artery disease; LUSC cis rs7681440 0.904 rs7680761 chr4:90763510 A/T cg01966878 chr4:90757139 SNCA -0.36 -6.22 -0.32 1.52e-9 Dementia with Lewy bodies; LUSC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg14784868 chr12:69753453 YEATS4 0.63 9.25 0.45 2.82e-18 Blood protein levels; LUSC cis rs12618769 0.597 rs12619665 chr2:99126551 A/T cg10123293 chr2:99228465 UNC50 0.43 6.94 0.35 2.08e-11 Bipolar disorder; LUSC cis rs617219 0.746 rs2591391 chr5:78546455 T/A cg24856658 chr5:78533917 JMY -0.3 -5.84 -0.3 1.24e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg22433210 chr17:43662623 NA 0.75 10.95 0.51 4.87e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg25072359 chr17:41440525 NA 0.64 9.02 0.44 1.51e-17 Menopause (age at onset); LUSC cis rs35883536 0.584 rs56112014 chr1:101037431 A/G cg06223162 chr1:101003688 GPR88 -0.46 -8.56 -0.42 4.21e-16 Monocyte count; LUSC cis rs2502731 1.000 rs2502731 chr9:130976557 A/G cg13642260 chr9:130955380 CIZ1 -0.57 -9.34 -0.46 1.35e-18 Attention deficit hyperactivity disorder; LUSC cis rs1185460 0.967 rs11217137 chr11:118931030 A/G cg23280166 chr11:118938394 VPS11 0.45 6.78 0.35 5.39e-11 Coronary artery disease; LUSC cis rs57920188 0.513 rs4290031 chr1:4094701 A/G cg20703997 chr1:4087676 NA 0.56 7.97 0.4 2.62e-14 Interleukin-17 levels; LUSC trans rs2201841 0.529 rs1532502 chr1:67737650 G/A cg16262963 chr14:104851903 NA -0.23 -5.97 -0.31 6.09e-9 Ulcerative colitis;Psoriasis;Crohn's disease; LUSC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg03709012 chr19:19516395 GATAD2A 0.85 14.66 0.63 6.35e-38 Tonsillectomy; LUSC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg06656553 chr16:89960601 TCF25 -0.65 -5.7 -0.3 2.62e-8 Skin colour saturation; LUSC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg09021430 chr5:549028 NA -0.55 -7.57 -0.38 3.64e-13 Obesity-related traits; LUSC cis rs62400317 0.859 rs10456542 chr6:45107579 G/A cg18551225 chr6:44695536 NA -0.43 -6.98 -0.36 1.63e-11 Total body bone mineral density; LUSC trans rs783147 0.500 rs4252126 chr6:161152294 A/G cg15416064 chr12:49209402 NA -0.42 -6.12 -0.32 2.6e-9 Lp (a) levels; LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.55 -0.53 3.41e-26 Alzheimer's disease; LUSC cis rs17270561 0.636 rs12194699 chr6:25729229 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.56 0.38 3.9e-13 Iron status biomarkers; LUSC cis rs7561273 0.545 rs12613951 chr2:24361962 G/A cg08063864 chr2:24346004 PFN4;LOC375190 -0.42 -5.82 -0.3 1.39e-8 Quantitative traits; LUSC cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg23711669 chr6:146136114 FBXO30 0.86 15.6 0.65 1.31e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs427941 0.703 rs201450 chr7:101739441 A/T cg06246474 chr7:101738831 CUX1 -0.41 -6.8 -0.35 4.87e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg01256987 chr12:42539512 GXYLT1 -0.46 -8.89 -0.44 3.79e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2797160 0.967 rs2747718 chr6:126009109 C/A cg05901451 chr6:126070800 HEY2 0.57 8.54 0.42 4.71e-16 Endometrial cancer; LUSC cis rs240764 0.717 rs151640 chr6:101111521 A/C cg09795085 chr6:101329169 ASCC3 0.41 5.97 0.31 6.12e-9 Neuroticism; LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg00012203 chr2:219082015 ARPC2 -0.7 -11.57 -0.53 2.97e-26 Colorectal cancer; LUSC cis rs11864453 0.927 rs1035560 chr16:72032730 T/C cg01557791 chr16:72042693 DHODH -0.54 -7.83 -0.39 6.58e-14 Fibrinogen levels; LUSC cis rs4961252 0.505 rs6990155 chr8:142098977 C/T cg13924514 chr8:142070760 NA 0.34 5.83 0.3 1.29e-8 Isovolumetric relaxation time;Response to interferon beta therapy; LUSC trans rs7178375 1.000 rs7169064 chr15:31210862 C/T cg04373760 chr16:53404718 NA 0.64 8.63 0.43 2.52e-16 Hypertriglyceridemia; LUSC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg06637938 chr14:75390232 RPS6KL1 0.52 8.33 0.41 2.07e-15 Height; LUSC cis rs2820315 1.000 rs903678 chr1:201809918 G/A cg10061532 chr1:201886748 LMOD1 0.26 5.93 0.31 7.44e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs1865760 1.000 rs6938233 chr6:25914077 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.76 0.35 6.02e-11 Height; LUSC cis rs858239 0.632 rs13438452 chr7:23174182 A/G cg23682824 chr7:23144976 KLHL7 0.4 5.89 0.31 9.46e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.7 12.54 0.57 7.93e-30 Personality dimensions; LUSC cis rs36051895 0.664 rs11793659 chr9:5109707 A/G cg02405213 chr9:5042618 JAK2 -0.57 -8.48 -0.42 7.47e-16 Pediatric autoimmune diseases; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg01238044 chr22:24384105 GSTT1 -0.48 -6.7 -0.34 9.06e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9807989 0.507 rs4851577 chr2:103028921 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.14e-12 Asthma; LUSC cis rs8017423 0.866 rs10184 chr14:90744672 G/A cg04374321 chr14:90722782 PSMC1 -0.68 -10.08 -0.48 4.79e-21 Mortality in heart failure; LUSC cis rs250677 1.000 rs250676 chr5:148425518 A/T cg18129178 chr5:148520854 ABLIM3 -0.67 -10.77 -0.51 2.07e-23 Breast cancer; LUSC cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.6 -0.43 3.09e-16 Axial length; LUSC cis rs2439831 0.867 rs12323999 chr15:43683115 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.91 9.73 0.47 7.58e-20 Lung cancer in ever smokers; LUSC cis rs977987 0.806 rs11643410 chr16:75428306 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.01 -0.36 1.34e-11 Dupuytren's disease; LUSC cis rs977987 0.806 rs1030262 chr16:75491327 C/A cg04384234 chr16:75411784 CFDP1 -0.42 -6.95 -0.36 1.87e-11 Dupuytren's disease; LUSC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg11752832 chr7:134001865 SLC35B4 0.59 9.29 0.45 2.08e-18 Mean platelet volume; LUSC cis rs6696846 0.765 rs4394715 chr1:205108393 T/G cg03948781 chr1:205179583 DSTYK 0.32 6.22 0.32 1.49e-9 Red blood cell count; LUSC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.49 -0.73 4.84e-57 Height; LUSC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg13798780 chr7:105162888 PUS7 0.61 6.55 0.34 2.14e-10 Bipolar disorder (body mass index interaction); LUSC cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg21427119 chr20:30132790 HM13 -0.42 -6.35 -0.33 6.96e-10 Mean corpuscular hemoglobin; LUSC cis rs1801251 1.000 rs12478564 chr2:233598340 C/T cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.33 3.01e-10 Coronary artery disease; LUSC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg16339924 chr4:17578868 LAP3 0.49 7.53 0.38 4.83e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg04267008 chr7:1944627 MAD1L1 -0.52 -7.53 -0.38 4.64e-13 Bipolar disorder and schizophrenia; LUSC cis rs738322 0.646 rs132972 chr22:38562056 T/C cg17652424 chr22:38574118 PLA2G6 -0.3 -6.52 -0.34 2.66e-10 Cutaneous nevi; LUSC trans rs9380880 0.826 rs12198307 chr6:39550197 C/T cg14673904 chr12:46609063 SLC38A1 0.54 5.99 0.31 5.41e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs13108904 0.870 rs2335855 chr4:1237968 T/C cg02475777 chr4:1388615 CRIPAK 0.39 5.91 0.31 8.3e-9 Obesity-related traits; LUSC cis rs4888262 0.526 rs8055803 chr16:74615190 A/G cg01733217 chr16:74700730 RFWD3 0.76 12.27 0.56 8.26e-29 Testicular germ cell tumor; LUSC cis rs7647973 1.000 rs3870339 chr3:49536863 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.54 0.38 4.44e-13 Menarche (age at onset); LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg01238044 chr22:24384105 GSTT1 -0.51 -7.46 -0.38 7.42e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs861020 0.606 rs2184919 chr1:210000015 C/T cg05527609 chr1:210001259 C1orf107 -0.63 -9.19 -0.45 4.27e-18 Orofacial clefts; LUSC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.66 15.12 0.64 1.07e-39 Hemoglobin concentration; LUSC cis rs4930561 0.765 rs4930229 chr11:67944080 G/A cg16338278 chr11:67432957 ALDH3B2 0.37 6.22 0.32 1.49e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs701145 0.556 rs355771 chr3:154039385 G/C cg17054900 chr3:154042577 DHX36 0.44 5.91 0.31 8.36e-9 Coronary artery disease; LUSC cis rs9300255 0.739 rs1969354 chr12:123741776 T/C cg00376283 chr12:123451042 ABCB9 0.66 8.32 0.41 2.27e-15 Neutrophil percentage of white cells; LUSC cis rs7584330 0.737 rs12469894 chr2:238365528 T/C cg16989719 chr2:238392110 NA -0.41 -7.25 -0.37 3e-12 Prostate cancer; LUSC cis rs6754311 0.593 rs10186843 chr2:136586958 C/A cg07169764 chr2:136633963 MCM6 -0.61 -8.02 -0.4 1.81e-14 Mosquito bite size; LUSC cis rs72634258 0.554 rs12745962 chr1:7919825 C/T cg26816564 chr1:7831052 VAMP3 0.71 9.66 0.47 1.23e-19 Inflammatory bowel disease; LUSC cis rs314370 0.855 rs17883557 chr7:100494949 G/T cg18683606 chr7:100471612 SRRT 0.46 6.12 0.32 2.56e-9 Resting heart rate; LUSC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg01879757 chr17:41196368 BRCA1 -0.47 -7.1 -0.36 7.7e-12 Menopause (age at onset); LUSC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg13628971 chr7:2884303 GNA12 0.47 6.69 0.34 9.34e-11 Height; LUSC cis rs8017423 0.935 rs12884698 chr14:90750566 G/A cg14092571 chr14:90743983 NA 0.35 5.71 0.3 2.5e-8 Mortality in heart failure; LUSC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg11764359 chr7:65958608 NA -0.7 -10.95 -0.51 4.95e-24 Aortic root size; LUSC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg08859206 chr1:53392774 SCP2 0.47 7.82 0.39 6.77e-14 Monocyte count; LUSC cis rs9905704 0.918 rs302867 chr17:56752819 C/T cg12560992 chr17:57184187 TRIM37 -0.52 -7.46 -0.38 7.5e-13 Testicular germ cell tumor; LUSC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg17971929 chr21:40555470 PSMG1 0.66 11.23 0.52 4.95e-25 Cognitive function; LUSC cis rs7572644 0.699 rs2337374 chr2:28200152 G/A cg27432699 chr2:27873401 GPN1 -0.51 -6.99 -0.36 1.52e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs208520 0.690 rs1304672 chr6:66847973 A/G cg07460842 chr6:66804631 NA 0.97 13.33 0.59 8.34e-33 Exhaled nitric oxide output; LUSC cis rs3768617 0.706 rs9943067 chr1:182975102 C/T ch.1.3577855R chr1:183094577 LAMC1 0.58 8.45 0.42 9.21e-16 Fuchs's corneal dystrophy; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.68 10.47 0.5 2.3e-22 Lymphocyte counts; LUSC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -7.45 -0.38 8e-13 Personality dimensions; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg20295408 chr7:1910781 MAD1L1 -0.51 -7.4 -0.38 1.12e-12 Bipolar disorder and schizophrenia; LUSC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg20276088 chr3:133502917 NA -0.44 -6.42 -0.33 4.57e-10 Iron status biomarkers; LUSC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg06219351 chr7:158114137 PTPRN2 -0.52 -9.55 -0.46 2.92e-19 Calcium levels; LUSC cis rs11585357 0.709 rs735281 chr1:17616194 T/C cg08277548 chr1:17600880 PADI3 0.61 6.66 0.34 1.1e-10 Hair shape; LUSC cis rs17030434 1.000 rs1456391 chr4:154720485 A/G cg14289246 chr4:154710475 SFRP2 -0.52 -6.78 -0.35 5.3e-11 Electrocardiographic conduction measures; LUSC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg04025307 chr7:1156635 C7orf50 0.44 6.85 0.35 3.52e-11 Longevity;Endometriosis; LUSC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg05368731 chr17:41323189 NBR1 0.82 13.37 0.59 6.03e-33 Menopause (age at onset); LUSC cis rs12579753 0.830 rs12825476 chr12:82238350 G/A cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07160044 chr13:24735301 SPATA13;MIR2276 -0.47 -6.09 -0.32 3.09e-9 Bipolar disorder and schizophrenia; LUSC cis rs478304 0.651 rs4014192 chr11:65498915 C/T cg27068330 chr11:65405492 SIPA1 -0.76 -10.88 -0.51 8.57e-24 Acne (severe); LUSC trans rs13390641 0.614 rs72930600 chr2:104067482 A/G cg03260781 chr1:16346299 HSPB7 -0.49 -6.3 -0.33 9.52e-10 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs1178968 0.901 rs1178958 chr7:72777384 G/A cg25889504 chr7:72793014 NA 0.6 7.77 0.39 9.92e-14 Triglyceride levels; LUSC cis rs7589342 0.831 rs11124062 chr2:106455967 G/A cg16077055 chr2:106428750 NCK2 0.37 6.92 0.35 2.25e-11 Addiction; LUSC cis rs1003719 0.788 rs9974286 chr21:38456832 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -8.98 -0.44 2.06e-17 Eye color traits; LUSC cis rs708547 0.874 rs1401190 chr4:57885174 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 8.98 0.44 2.08e-17 Response to bleomycin (chromatid breaks); LUSC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg06108461 chr20:60628389 TAF4 0.61 7.84 0.39 6.14e-14 Obesity-related traits; LUSC trans rs2243480 1.000 rs316321 chr7:65611613 G/A cg10756647 chr7:56101905 PSPH 0.88 8.91 0.44 3.39e-17 Diabetic kidney disease; LUSC cis rs7712401 0.562 rs30053 chr5:122303643 C/G cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC trans rs7681440 0.904 rs6532192 chr4:90764131 G/A cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.01 -0.31 4.92e-9 Dementia with Lewy bodies; LUSC cis rs9911578 0.835 rs9303398 chr17:56484257 T/C cg05425664 chr17:57184151 TRIM37 0.55 8.57 0.42 3.81e-16 Intelligence (multi-trait analysis); LUSC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg09509183 chr1:209979624 IRF6 0.5 5.71 0.3 2.55e-8 Cleft lip with or without cleft palate; LUSC cis rs2637266 0.783 rs846627 chr10:78539556 A/G cg18941641 chr10:78392320 NA 0.37 6.63 0.34 1.33e-10 Pulmonary function; LUSC cis rs4363385 0.818 rs370162 chr1:153005488 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -12.08 -0.55 3.93e-28 Type 2 diabetes; LUSC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg04362960 chr10:104952993 NT5C2 0.58 9.18 0.45 4.58e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7586879 0.929 rs6545808 chr2:25124388 C/A cg04586622 chr2:25135609 ADCY3 0.32 6.14 0.32 2.4e-9 Body mass index; LUSC cis rs11971779 0.584 rs10236055 chr7:139069991 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs13064411 0.696 rs9839921 chr3:113199093 G/C cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs6163 0.588 rs67506723 chr10:104509064 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -6.57 -0.34 1.98e-10 Waist circumference;Hip circumference; LUSC cis rs834811 0.871 rs834819 chr7:135895281 G/A cg01726295 chr7:135938950 NA 0.36 6.24 0.32 1.31e-9 Post-traumatic stress disorder; LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg24813613 chr7:1882135 MAD1L1 -0.42 -7.15 -0.36 5.5e-12 Bipolar disorder and schizophrenia; LUSC cis rs3741151 1.000 rs7122825 chr11:73061324 C/T cg17517138 chr11:73019481 ARHGEF17 1.02 8.59 0.43 3.43e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs12200560 0.505 rs211179 chr6:97074103 A/G cg06623918 chr6:96969491 KIAA0776 0.51 7.33 0.37 1.78e-12 Coronary heart disease; LUSC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg21361702 chr7:150065534 REPIN1 0.5 6.5 0.34 2.92e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs1950626 0.833 rs35436326 chr14:101396148 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.41 7.33 0.37 1.77e-12 Pelvic organ prolapse (moderate/severe); LUSC cis rs9296095 0.948 rs75080135 chr6:33552707 A/C cg14003231 chr6:33640908 ITPR3 0.48 7.1 0.36 7.7e-12 Platelet count; LUSC cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg12935359 chr14:103987150 CKB 0.66 10.71 0.51 3.27e-23 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg17385448 chr1:15911702 AGMAT 0.34 5.69 0.3 2.79e-8 Systolic blood pressure; LUSC cis rs7568458 0.837 rs3731827 chr2:85806068 T/C cg23752985 chr2:85803571 VAMP8 0.37 8.0 0.4 2.03e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg05622550 chr15:74315474 PML -0.39 -5.94 -0.31 6.97e-9 N-glycan levels; LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg24675658 chr1:53192096 ZYG11B 0.6 9.33 0.45 1.51e-18 Monocyte count; LUSC cis rs9522267 0.559 rs9522300 chr13:112236668 C/G cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 2.99e-8 Hepatitis; LUSC cis rs6580649 0.783 rs7969749 chr12:48550755 C/T cg24011408 chr12:48396354 COL2A1 0.46 6.3 0.33 9.31e-10 Lung cancer; LUSC cis rs1448094 0.967 rs1374995 chr12:86341764 A/G cg18827107 chr12:86230957 RASSF9 -0.39 -5.79 -0.3 1.67e-8 Major depressive disorder; LUSC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg14440974 chr22:39074834 NA 0.36 6.16 0.32 2.11e-9 Menopause (age at onset); LUSC cis rs1691799 0.836 rs1184552 chr12:66756215 A/G cg16791601 chr12:66731901 HELB -0.71 -12.39 -0.56 2.99e-29 White blood cell count (basophil); LUSC trans rs877282 0.853 rs11595507 chr10:756703 C/T cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22516733 chr7:2281617 NUDT1;FTSJ2 -0.39 -5.96 -0.31 6.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg01802117 chr1:53393560 SCP2 -0.41 -6.83 -0.35 4.01e-11 Monocyte count; LUSC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.35 0.53 1.79e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg08847533 chr14:75593920 NEK9 0.8 13.95 0.61 3.72e-35 Height; LUSC cis rs66731853 0.769 rs476582 chr1:20894450 A/G cg04087271 chr1:20915334 CDA -0.52 -8.62 -0.43 2.77e-16 Mean corpuscular volume; LUSC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC trans rs6582630 0.502 rs11181475 chr12:38348922 G/A cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.28e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg08219700 chr8:58056026 NA 0.64 8.51 0.42 5.97e-16 Developmental language disorder (linguistic errors); LUSC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs782590 0.869 rs782599 chr2:55847423 C/T cg18811423 chr2:55921094 PNPT1 0.78 13.25 0.59 1.72e-32 Metabolic syndrome; LUSC cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg15962314 chr1:44399869 ARTN 0.31 6.95 0.36 1.95e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg05425664 chr17:57184151 TRIM37 -0.56 -8.28 -0.41 2.93e-15 Intelligence (multi-trait analysis); LUSC cis rs7106204 0.800 rs7120940 chr11:24236485 C/A ch.11.24196551F chr11:24239977 NA 1.14 14.25 0.61 2.52e-36 Response to Homoharringtonine (cytotoxicity); LUSC cis rs708547 0.581 rs13121027 chr4:57813369 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.51 -7.59 -0.38 3.23e-13 Response to bleomycin (chromatid breaks); LUSC cis rs7760535 0.811 rs455732 chr6:111695268 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Metabolic traits; LUSC cis rs7408868 0.706 rs2238642 chr19:15282237 T/C cg14696996 chr19:15285081 NOTCH3 0.82 8.3 0.41 2.59e-15 Pulse pressure; LUSC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg14196790 chr5:131705035 SLC22A5 -0.36 -5.95 -0.31 6.83e-9 Blood metabolite levels; LUSC trans rs6951245 0.872 rs77434655 chr7:1098405 G/A cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9487051 0.676 rs9386788 chr6:109600523 C/T cg01475377 chr6:109611718 NA 0.36 6.46 0.33 3.77e-10 Reticulocyte fraction of red cells; LUSC cis rs6500602 0.592 rs3747585 chr16:4519140 C/G cg08645402 chr16:4508243 NA 0.52 8.24 0.41 4.07e-15 Schizophrenia; LUSC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg05776053 chr2:74358815 NA 0.45 7.19 0.37 4.38e-12 Gestational age at birth (maternal effect); LUSC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg06363034 chr20:62225388 GMEB2 -0.46 -7.7 -0.39 1.51e-13 Glioblastoma; LUSC cis rs2835872 0.828 rs2835839 chr21:38991034 A/G cg20424643 chr21:39039972 KCNJ6 0.43 6.63 0.34 1.39e-10 Electroencephalographic traits in alcoholism; LUSC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg07937631 chr13:79184529 NA -0.42 -6.85 -0.35 3.5e-11 Large artery stroke; LUSC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg00750074 chr16:89608354 SPG7 0.45 7.83 0.39 6.69e-14 Multiple myeloma (IgH translocation); LUSC cis rs9906944 0.707 rs8068981 chr17:47122525 T/C cg14634687 chr17:47094252 IGF2BP1 0.31 6.61 0.34 1.55e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs4842666 0.850 rs11105328 chr12:89942390 A/G cg00757033 chr12:89920650 WDR51B 0.46 6.57 0.34 1.94e-10 Blood pressure; LUSC trans rs8020912 0.504 rs3759577 chr14:103850963 C/T cg17675199 chr6:35436792 RPL10A -0.47 -6.1 -0.32 3.01e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs11264799 0.603 rs12731814 chr1:157585917 G/A cg18268488 chr1:157545234 FCRL4 0.35 6.51 0.34 2.82e-10 IgA nephropathy; LUSC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.4 -5.73 -0.3 2.2e-8 Tonsillectomy; LUSC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg01475377 chr6:109611718 NA -0.41 -7.33 -0.37 1.75e-12 Reticulocyte fraction of red cells; LUSC cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg06784218 chr1:46089804 CCDC17 -0.47 -9.06 -0.44 1.09e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1580019 0.961 rs4357201 chr7:32496333 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.81 0.54 3.97e-27 Cognitive ability; LUSC cis rs7795096 0.743 rs9648729 chr7:151537759 G/C cg17008978 chr7:151542804 PRKAG2 0.34 6.53 0.34 2.44e-10 Bipolar disorder (age of onset and psychotic symptoms); LUSC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg07061783 chr6:25882402 NA 0.43 6.06 0.31 3.6e-9 Blood metabolite levels; LUSC cis rs7572644 0.640 rs4666022 chr2:28057823 T/C cg27432699 chr2:27873401 GPN1 0.51 6.96 0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.83 12.56 0.57 6.5e-30 Cognitive test performance; LUSC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg13390004 chr1:15929781 NA 0.42 6.93 0.35 2.17e-11 Systolic blood pressure; LUSC cis rs2836633 0.859 rs8132069 chr21:40032611 T/C cg05519781 chr21:40033154 ERG 0.77 13.3 0.59 1.09e-32 Coronary artery disease; LUSC trans rs1908814 0.516 rs11250178 chr8:11800234 A/C cg27411982 chr8:10470053 RP1L1 0.41 6.32 0.33 8.46e-10 Neuroticism; LUSC cis rs3820928 0.874 rs3752895 chr2:227886773 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.97 -0.4 2.46e-14 Pulmonary function; LUSC cis rs7428 0.527 rs1554110 chr2:85547963 C/T cg24342717 chr2:85555507 TGOLN2 -0.74 -12.28 -0.56 7.19e-29 Ear protrusion; LUSC cis rs3126085 0.735 rs4845744 chr1:152185095 T/A cg03465714 chr1:152285911 FLG -0.42 -5.88 -0.31 9.75e-9 Atopic dermatitis; LUSC cis rs2067615 0.524 rs4964187 chr12:107080313 C/A cg15890332 chr12:107067104 RFX4 0.35 6.13 0.32 2.51e-9 Heart rate; LUSC cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg10523860 chr14:103875565 MARK3 -0.37 -5.9 -0.31 9.07e-9 Body mass index; LUSC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg04414720 chr1:150670196 GOLPH3L 0.57 8.71 0.43 1.44e-16 Melanoma; LUSC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg07936489 chr17:37558343 FBXL20 -0.71 -9.8 -0.47 4.37e-20 Glomerular filtration rate (creatinine); LUSC cis rs2463822 1.000 rs2463822 chr11:62103420 T/C cg06239285 chr11:62104954 ASRGL1 0.95 10.39 0.49 4.15e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7824557 0.602 rs11784458 chr8:11204184 G/A cg08975724 chr8:8085496 FLJ10661 0.43 6.2 0.32 1.67e-9 Retinal vascular caliber; LUSC trans rs1325195 0.920 rs2636274 chr1:179106899 A/G cg11624085 chr17:8464688 MYH10 0.44 7.3 0.37 2.14e-12 IgE grass sensitization; LUSC trans rs877282 0.945 rs71489301 chr10:770191 A/G cg22713356 chr15:30763199 NA 1.07 15.32 0.64 1.77e-40 Uric acid levels; LUSC cis rs2857891 0.695 rs2468986 chr11:6986027 G/C cg04053776 chr11:6947353 ZNF215 0.39 5.78 0.3 1.73e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg05985134 chr18:33552581 C18orf21 0.52 6.97 0.36 1.65e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg18357526 chr6:26021779 HIST1H4A 0.4 6.09 0.32 3.02e-9 Intelligence (multi-trait analysis); LUSC trans rs941408 1.000 rs1640271 chr19:2799979 C/T cg19676328 chr12:49525230 TUBA1B -0.52 -8.57 -0.42 4.01e-16 Total cholesterol levels; LUSC trans rs11039798 1.000 rs3902927 chr11:48581457 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.51 0.34 2.81e-10 Axial length; LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg16325326 chr1:53192061 ZYG11B -0.9 -16.97 -0.68 4.92e-47 Monocyte count; LUSC cis rs11098499 0.754 rs2036860 chr4:120248934 A/G cg24375607 chr4:120327624 NA 0.76 12.19 0.55 1.64e-28 Corneal astigmatism; LUSC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg06221963 chr1:154839813 KCNN3 -0.67 -16.35 -0.67 1.5e-44 Prostate cancer; LUSC cis rs11828289 0.660 rs17306398 chr11:23192235 G/T cg20040320 chr11:23191996 NA 0.58 6.07 0.32 3.5e-9 Cancer; LUSC cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs950881 0.932 rs72823632 chr2:102931534 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.36 0.33 6.7e-10 Allergy; LUSC cis rs367615 0.704 rs11747622 chr5:108844720 G/A cg17395555 chr5:108820864 NA 0.59 11.06 0.52 1.95e-24 Colorectal cancer (SNP x SNP interaction); LUSC cis rs6574644 0.959 rs6574645 chr14:81778768 A/G cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.33 0.49 6.71e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1577917 1.000 rs10455158 chr6:86672825 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.64 -0.34 1.26e-10 Response to antipsychotic treatment; LUSC cis rs2274273 0.624 rs10146637 chr14:55744810 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.8 0.47 4.34e-20 Protein biomarker; LUSC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.49e-34 Aortic root size; LUSC cis rs7568458 0.709 rs2592551 chr2:85780131 G/A cg17127132 chr2:85788382 GGCX 0.43 6.23 0.32 1.39e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7089973 0.872 rs7918388 chr10:116614563 T/C cg23260525 chr10:116636907 FAM160B1 0.4 8.26 0.41 3.52e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs11098499 0.955 rs13114751 chr4:120156617 G/A cg25214090 chr10:38739885 LOC399744 0.45 6.6 0.34 1.61e-10 Corneal astigmatism; LUSC cis rs9788721 0.868 rs17486278 chr15:78867482 A/C cg06917634 chr15:78832804 PSMA4 -0.42 -5.81 -0.3 1.43e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg12560992 chr17:57184187 TRIM37 -0.85 -15.42 -0.64 6.9e-41 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.91 -0.48 1.76e-20 Glomerular filtration rate (creatinine); LUSC cis rs6500602 0.727 rs2058811 chr16:4575162 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 7.53 0.38 4.74e-13 Schizophrenia; LUSC trans rs9329221 0.521 rs17693945 chr8:10106010 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.64 -0.34 1.26e-10 Neuroticism; LUSC cis rs17253792 0.822 rs79262019 chr14:56092704 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs11122272 0.735 rs2790882 chr1:231532783 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.66 10.45 0.5 2.65e-22 Hemoglobin concentration; LUSC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg01416388 chr22:39784598 NA -0.43 -7.17 -0.37 4.92e-12 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.705 rs59502343 chr1:15872617 T/C cg17385448 chr1:15911702 AGMAT 0.38 5.91 0.31 8.64e-9 Systolic blood pressure; LUSC cis rs4786125 0.920 rs6500849 chr16:6895246 C/T cg03623568 chr16:6915990 A2BP1 -0.44 -7.31 -0.37 2.01e-12 Heart rate variability traits (SDNN); LUSC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg07936489 chr17:37558343 FBXL20 0.7 9.9 0.48 1.99e-20 Glomerular filtration rate (creatinine); LUSC cis rs10465746 0.687 rs6576954 chr1:84323701 C/T cg10977910 chr1:84465055 TTLL7 -0.4 -5.73 -0.3 2.26e-8 Obesity-related traits; LUSC cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg01657329 chr11:68192670 LRP5 -0.49 -7.72 -0.39 1.32e-13 Total body bone mineral density; LUSC cis rs7584330 0.541 rs10202181 chr2:238352099 A/G cg14458575 chr2:238380390 NA 0.68 11.73 0.54 7.35e-27 Prostate cancer; LUSC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg17911788 chr17:44343683 NA -0.31 -5.96 -0.31 6.45e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg19592336 chr6:28129416 ZNF389 -0.43 -6.04 -0.31 4.04e-9 Depression; LUSC cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg20283391 chr11:68216788 NA -0.58 -8.22 -0.41 4.56e-15 Total body bone mineral density; LUSC cis rs3858526 0.834 rs6578712 chr11:5987071 C/T cg13902645 chr11:5959945 NA -0.61 -8.38 -0.42 1.45e-15 DNA methylation (variation); LUSC cis rs9905704 0.647 rs2036730 chr17:57038282 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.46 -0.38 7.72e-13 Testicular germ cell tumor; LUSC cis rs6435862 0.593 rs34732883 chr2:215674371 C/T cg04004882 chr2:215674386 BARD1 -0.59 -8.71 -0.43 1.4e-16 Neuroblastoma (high-risk); LUSC cis rs1577917 1.000 rs6914463 chr6:86653415 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.37 -0.42 1.6e-15 Response to antipsychotic treatment; LUSC cis rs936229 0.861 rs3935077 chr15:75120211 C/G cg10253484 chr15:75165896 SCAMP2 -0.5 -6.56 -0.34 2e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs6502050 0.835 rs67634087 chr17:80118168 C/T cg07393940 chr7:158741817 NA 0.36 6.58 0.34 1.84e-10 Life satisfaction; LUSC cis rs2303282 0.664 rs2550310 chr16:56438110 C/T cg00500540 chr16:56394104 NA -0.39 -6.7 -0.34 8.91e-11 Breast cancer; LUSC cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg06552810 chr11:31128660 NA -0.42 -7.37 -0.37 1.37e-12 Red blood cell count; LUSC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11644478 chr21:40555479 PSMG1 0.88 15.48 0.65 3.97e-41 Cognitive function; LUSC trans rs877282 0.583 rs12356155 chr10:823940 C/T cg22713356 chr15:30763199 NA 0.78 10.12 0.48 3.54e-21 Uric acid levels; LUSC cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg27490568 chr2:178487706 NA -0.41 -5.81 -0.3 1.46e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs748404 0.631 rs4296223 chr15:43645246 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.32 0.33 8.32e-10 Lung cancer; LUSC cis rs796364 0.806 rs10445792 chr2:201078821 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.81 -0.39 7.65e-14 Schizophrenia; LUSC cis rs290268 0.874 rs772407 chr9:93560850 A/C cg02608019 chr9:93564028 SYK 0.55 9.32 0.45 1.58e-18 Platelet count; LUSC cis rs8017423 0.647 rs12882973 chr14:90820502 G/A cg04374321 chr14:90722782 PSMC1 -0.44 -6.63 -0.34 1.34e-10 Mortality in heart failure; LUSC cis rs6964587 1.000 rs2106171 chr7:91750450 A/G cg22117172 chr7:91764530 CYP51A1 0.33 5.83 0.3 1.34e-8 Breast cancer; LUSC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg04362960 chr10:104952993 NT5C2 0.59 9.53 0.46 3.42e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg03929089 chr4:120376271 NA -0.94 -16.46 -0.67 5.66e-45 Height; LUSC cis rs6496667 0.533 rs2074584 chr15:91009381 C/T cg22089800 chr15:90895588 ZNF774 0.51 7.35 0.37 1.5e-12 Rheumatoid arthritis; LUSC cis rs9372498 0.536 rs62422224 chr6:118941116 G/A cg18833306 chr6:118973337 C6orf204 -0.46 -5.74 -0.3 2.14e-8 Diastolic blood pressure; LUSC cis rs6496667 0.509 rs57962570 chr15:90985596 C/G cg22089800 chr15:90895588 ZNF774 0.52 7.43 0.38 9.3e-13 Rheumatoid arthritis; LUSC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg23262073 chr20:60523788 NA -0.43 -6.16 -0.32 2.08e-9 Body mass index; LUSC trans rs9329221 0.537 rs13264586 chr8:9979385 T/C cg15556689 chr8:8085844 FLJ10661 0.55 8.12 0.41 9.37e-15 Neuroticism; LUSC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg25019033 chr10:957182 NA -0.51 -6.44 -0.33 4.2e-10 Eosinophil percentage of granulocytes; LUSC cis rs2224391 1.000 rs2753246 chr6:5261845 A/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.65 -0.34 1.17e-10 Height; LUSC cis rs7107174 1.000 rs2511178 chr11:77923220 C/T cg02023728 chr11:77925099 USP35 0.53 7.53 0.38 4.91e-13 Testicular germ cell tumor; LUSC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg03609598 chr5:56110824 MAP3K1 -0.42 -6.25 -0.32 1.26e-9 Initial pursuit acceleration; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -8.09 -0.4 1.14e-14 Bipolar disorder and schizophrenia; LUSC cis rs10751667 0.600 rs10751665 chr11:941300 G/A ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs113601626 1 rs113601626 chr2:24239189 T/TCCTGGC cg20701182 chr2:24300061 SF3B14 0.75 7.54 0.38 4.62e-13 Lymphocyte percentage of white cells; LUSC cis rs477692 0.935 rs557158 chr10:131420534 C/T cg11019008 chr10:131425282 MGMT 0.39 5.87 0.31 1.06e-8 Response to temozolomide; LUSC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg06637938 chr14:75390232 RPS6KL1 0.54 8.55 0.42 4.57e-16 Height; LUSC cis rs3101457 0.515 rs4658632 chr1:244516949 G/T cg09033006 chr1:244517177 C1orf100 -0.44 -6.37 -0.33 6.19e-10 Smoking behavior; LUSC cis rs7665590 1 rs7665590 chr4:99796784 T/C cg12011299 chr4:100065546 ADH4 -0.36 -5.69 -0.3 2.75e-8 Primary biliary cholangitis; LUSC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg18850127 chr7:39170497 POU6F2 0.66 10.63 0.5 6.52e-23 IgG glycosylation; LUSC cis rs3749237 0.964 rs11717463 chr3:49808981 C/T cg03060546 chr3:49711283 APEH 0.64 8.35 0.42 1.83e-15 Resting heart rate; LUSC cis rs731174 0.797 rs539585 chr1:38148123 T/G cg14170840 chr1:38155120 C1orf109 -0.38 -5.97 -0.31 6.21e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs911555 0.755 rs2756135 chr14:103962579 G/A cg24130564 chr14:104152367 KLC1 0.46 6.55 0.34 2.17e-10 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg04944784 chr2:26401820 FAM59B -0.72 -10.02 -0.48 7.51e-21 Gut microbiome composition (summer); LUSC cis rs12200782 0.872 rs3757149 chr6:26381316 C/T cg23155468 chr6:27110703 HIST1H2BK 0.58 5.98 0.31 5.76e-9 Small cell lung carcinoma; LUSC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg17376030 chr22:41985996 PMM1 -0.48 -6.02 -0.31 4.57e-9 Vitiligo; LUSC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6582630 0.524 rs10785494 chr12:38532431 C/G cg26384229 chr12:38710491 ALG10B -0.55 -8.3 -0.41 2.56e-15 Drug-induced liver injury (flucloxacillin); LUSC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.36 -0.33 6.53e-10 Neuroticism; LUSC cis rs11711311 0.955 rs12630791 chr3:113387717 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.46 -6.21 -0.32 1.56e-9 IgG glycosylation; LUSC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg13385521 chr17:29058706 SUZ12P 0.66 6.43 0.33 4.49e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs72802342 0.510 rs12932952 chr16:75365486 C/T cg04384234 chr16:75411784 CFDP1 -0.64 -8.94 -0.44 2.73e-17 Advanced age-related macular degeneration; LUSC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.69 -10.92 -0.51 5.94e-24 Menarche (age at onset); LUSC cis rs780094 0.500 rs4665382 chr2:27783801 T/C cg27432699 chr2:27873401 GPN1 0.4 5.65 0.3 3.43e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg01448562 chr3:133502909 NA -0.66 -10.84 -0.51 1.19e-23 Iron status biomarkers; LUSC cis rs2742234 0.541 rs11238476 chr10:43711436 G/T cg15436174 chr10:43711423 RASGEF1A 0.44 7.03 0.36 1.14e-11 Hirschsprung disease; LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.13 0.32 2.45e-9 Menopause (age at onset); LUSC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.49e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1550582 0.662 rs4909628 chr8:135502380 A/T cg17885191 chr8:135476712 NA -0.89 -14.27 -0.62 2.02e-36 Educational attainment; LUSC cis rs6840360 0.615 rs10001603 chr4:152647577 T/A cg22705602 chr4:152727874 NA -0.35 -7.56 -0.38 3.94e-13 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC cis rs155076 0.938 rs261375 chr13:21871882 A/G cg25811766 chr13:21894605 NA 0.65 7.49 0.38 6.27e-13 White matter hyperintensity burden; LUSC trans rs2243480 1.000 rs2462569 chr7:65474846 C/T cg10756647 chr7:56101905 PSPH -0.84 -8.49 -0.42 7.1e-16 Diabetic kidney disease; LUSC trans rs9388451 0.839 rs980014 chr6:126068001 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.61 -9.77 -0.47 5.34e-20 Brugada syndrome; LUSC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg23625390 chr15:77176239 SCAPER 0.5 7.68 0.39 1.77e-13 Blood metabolite levels; LUSC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg20891283 chr12:69753455 YEATS4 -0.91 -17.61 -0.69 1.5e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs2708977 1.000 rs10184209 chr2:97337491 G/T cg01950434 chr2:97203154 ARID5A 0.57 8.75 0.43 1.1e-16 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC cis rs10208940 0.841 rs7581931 chr2:68791641 A/G cg12452813 chr2:68675892 NA 0.57 5.92 0.31 7.99e-9 Urate levels in lean individuals; LUSC cis rs1448094 0.872 rs7305869 chr12:86440114 A/G cg02569458 chr12:86230093 RASSF9 0.37 6.03 0.31 4.39e-9 Major depressive disorder; LUSC trans rs2797160 1.000 rs1578794 chr6:126015469 T/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.88 0.35 3.01e-11 Endometrial cancer; LUSC cis rs7824557 0.583 rs2736292 chr8:11234500 A/T cg27411982 chr8:10470053 RP1L1 0.35 5.67 0.3 3.04e-8 Retinal vascular caliber; LUSC cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg26384229 chr12:38710491 ALG10B 0.88 15.06 0.64 1.82e-39 Bladder cancer; LUSC cis rs10752881 0.905 rs10797830 chr1:183036274 A/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.95 0.51 4.59e-24 Colorectal cancer; LUSC cis rs7178572 0.568 rs12910480 chr15:77664212 G/C cg22256960 chr15:77711686 NA -0.51 -8.09 -0.4 1.11e-14 Type 2 diabetes; LUSC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg01802117 chr1:53393560 SCP2 -0.37 -5.93 -0.31 7.62e-9 Monocyte count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05303728 chr8:32078368 NRG1 0.4 6.04 0.31 4.19e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg19717235 chr4:154170410 TRIM2 0.43 6.66 0.34 1.15e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13732083 chr21:47605072 C21orf56 0.43 6.25 0.32 1.27e-9 Testicular germ cell tumor; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19223106 chr19:58898630 RPS5 -0.38 -6.31 -0.33 8.84e-10 Electrocardiographic conduction measures; LUSC trans rs7939886 0.920 rs11227321 chr11:55904828 A/G cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs672059 0.513 rs572977 chr1:183164991 C/G ch.1.3577855R chr1:183094577 LAMC1 0.45 6.11 0.32 2.78e-9 Hypertriglyceridemia; LUSC cis rs2963155 0.518 rs712189 chr5:142631258 C/T cg17617527 chr5:142782415 NR3C1 0.71 8.42 0.42 1.14e-15 Breast cancer; LUSC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg26380479 chr7:97908229 NA -0.26 -5.94 -0.31 7.22e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9296092 0.538 rs62407567 chr6:33537213 A/G cg13560919 chr6:33536144 NA -0.89 -15.74 -0.65 3.75e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs919433 0.519 rs700656 chr2:198653667 T/C cg00792783 chr2:198669748 PLCL1 0.43 5.77 0.3 1.78e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs11158026 0.603 rs57667631 chr14:55443067 G/A cg04306507 chr14:55594613 LGALS3 0.4 7.2 0.37 4.11e-12 Parkinson's disease; LUSC cis rs4319547 0.695 rs4758648 chr12:122900460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.49 -0.42 6.93e-16 Body mass index; LUSC cis rs35123781 0.502 rs261532 chr5:138949362 A/C cg12205435 chr5:138714322 SLC23A1 0.45 6.66 0.34 1.11e-10 Schizophrenia; LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg18404041 chr3:52824283 ITIH1 -0.69 -13.08 -0.58 7.38e-32 Bipolar disorder; LUSC cis rs4478858 0.743 rs11578422 chr1:31707298 C/T cg00250761 chr1:31883323 NA -0.36 -9.38 -0.46 1.05e-18 Alcohol dependence; LUSC cis rs9463078 0.547 rs9472336 chr6:44710392 G/A cg25276700 chr6:44698697 NA 0.3 6.2 0.32 1.66e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2481665 0.765 rs2481678 chr1:62634020 T/C cg18591186 chr1:62594603 INADL -0.38 -5.81 -0.3 1.45e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2738048 0.545 rs2738168 chr8:6824577 G/T cg24860332 chr8:6827800 DEFA10P -0.42 -6.79 -0.35 5.3e-11 IgA nephropathy; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg12078486 chr1:155108334 RAG1AP1 0.51 6.09 0.32 3.07e-9 Allergic disease (asthma, hay fever or eczema); LUSC trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg27661571 chr11:113659931 NA -0.7 -7.96 -0.4 2.78e-14 Hip circumference adjusted for BMI; LUSC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg20821713 chr7:1055600 C7orf50 -0.56 -7.36 -0.37 1.42e-12 Bronchopulmonary dysplasia; LUSC trans rs12439619 0.693 rs9944185 chr15:82450268 G/T cg04831495 chr15:85060580 GOLGA6L5 -0.43 -6.16 -0.32 2.03e-9 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.546 rs7188350 chr16:68149316 T/C cg05110241 chr16:68378359 PRMT7 -0.45 -5.96 -0.31 6.5e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs73200209 0.744 rs7133286 chr12:116483965 A/C cg01776926 chr12:116560359 MED13L -0.5 -5.97 -0.31 6.1e-9 Total body bone mineral density; LUSC cis rs11711311 1.000 rs9865965 chr3:113450495 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC cis rs9653442 0.777 rs6732141 chr2:100743492 G/C cg07810366 chr2:100720526 AFF3 -0.53 -9.36 -0.46 1.19e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs28595532 0.702 rs116320061 chr4:119384600 C/T cg21605333 chr4:119757512 SEC24D 1.02 8.29 0.41 2.73e-15 Cannabis dependence symptom count; LUSC cis rs2346177 0.875 rs4413204 chr2:46647092 C/G cg02822958 chr2:46747628 ATP6V1E2 0.35 5.87 0.31 1.06e-8 HDL cholesterol; LUSC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg10792982 chr14:105748885 BRF1 0.47 8.47 0.42 7.83e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs8017423 0.647 rs4904673 chr14:90817338 G/A cg04374321 chr14:90722782 PSMC1 -0.43 -6.6 -0.34 1.65e-10 Mortality in heart failure; LUSC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg18305652 chr10:134549665 INPP5A 0.46 6.83 0.35 4.01e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2050392 0.737 rs7898978 chr10:30699800 T/C cg18806716 chr10:30721971 MAP3K8 0.72 11.51 0.53 4.65e-26 Inflammatory bowel disease; LUSC cis rs868036 1.000 rs868037 chr15:68054996 A/G cg05925327 chr15:68127851 NA 0.32 5.73 0.3 2.28e-8 Restless legs syndrome; LUSC cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg25817165 chr18:72167213 CNDP2 -0.72 -9.53 -0.46 3.31e-19 Refractive error; LUSC cis rs4629710 0.568 rs9492883 chr6:131573872 A/T cg12606694 chr6:131520996 AKAP7 0.62 9.42 0.46 7.5e-19 Multiple myeloma (IgH translocation); LUSC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.47 6.94 0.35 2.05e-11 Schizophrenia; LUSC trans rs1459104 0.866 rs35456973 chr11:54838812 C/A cg15704280 chr7:45808275 SEPT13 0.71 6.34 0.33 7.62e-10 Body mass index; LUSC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg03526776 chr6:41159608 TREML2 0.32 6.14 0.32 2.35e-9 Alzheimer's disease (late onset); LUSC cis rs3850699 0.609 rs12763720 chr10:104241983 T/C cg04362960 chr10:104952993 NT5C2 0.52 6.51 0.34 2.7e-10 Prostate cancer; LUSC trans rs35110281 0.659 rs2236667 chr21:45112939 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 10.79 0.51 1.76e-23 Mean corpuscular volume; LUSC cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg23711669 chr6:146136114 FBXO30 0.78 14.1 0.61 9.42e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs3903072 0.528 rs7928652 chr11:65580228 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.35 6.0 0.31 5.05e-9 Breast cancer; LUSC cis rs12291225 0.679 rs4756786 chr11:14285900 C/A cg05501817 chr11:14380813 RRAS2 -0.55 -8.6 -0.43 3.25e-16 Sense of smell; LUSC cis rs9902453 0.765 rs2169810 chr17:28167941 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.33 0.53 2.18e-25 Coffee consumption (cups per day); LUSC trans rs984440 0.621 rs35542762 chr8:139077352 C/T cg03334052 chr1:168888044 NA -0.4 -6.32 -0.33 8.35e-10 Obesity-related traits; LUSC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg23711669 chr6:146136114 FBXO30 0.87 15.46 0.65 4.67e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs11190604 1.000 rs2489034 chr10:102319192 C/T cg16342193 chr10:102329863 NA -0.37 -6.41 -0.33 4.83e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12310956 0.532 rs10844715 chr12:33968444 A/G cg06521331 chr12:34319734 NA -0.44 -7.27 -0.37 2.54e-12 Morning vs. evening chronotype; LUSC cis rs6582630 0.599 rs4882313 chr12:38454011 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.49e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.92 -0.44 3.02e-17 Monocyte percentage of white cells; LUSC trans rs61931739 0.500 rs12829125 chr12:34314789 A/G cg13010199 chr12:38710504 ALG10B 0.54 8.45 0.42 9.36e-16 Morning vs. evening chronotype; LUSC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg05890377 chr2:74357713 NA 0.7 12.22 0.56 1.18e-28 Gestational age at birth (maternal effect); LUSC cis rs739401 0.611 rs572373 chr11:3055361 T/C cg08508325 chr11:3079039 CARS -0.54 -13.44 -0.59 3.17e-33 Longevity; LUSC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg21433313 chr16:3507492 NAT15 0.77 9.51 0.46 3.83e-19 Tuberculosis; LUSC cis rs6754311 0.551 rs313526 chr2:136445526 C/T cg07169764 chr2:136633963 MCM6 0.55 7.29 0.37 2.32e-12 Mosquito bite size; LUSC cis rs231513 1.000 rs231526 chr17:41951277 T/C cg26893861 chr17:41843967 DUSP3 -0.58 -6.17 -0.32 1.95e-9 Cognitive function; LUSC cis rs8060686 0.641 rs12447640 chr16:68150527 A/G cg04539111 chr16:67997858 SLC12A4 -0.45 -6.03 -0.31 4.27e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs9393777 0.920 rs34953377 chr6:27381660 T/C cg01620082 chr3:125678407 NA -0.79 -7.21 -0.37 3.81e-12 Intelligence (multi-trait analysis); LUSC cis rs17665859 0.844 rs17738513 chr8:446359 G/T cg17960703 chr8:356704 FBXO25 -0.85 -8.01 -0.4 1.91e-14 Bilirubin levels; LUSC cis rs4363385 0.553 rs1415972 chr1:152953552 A/G cg00922841 chr1:152955080 SPRR1A 0.37 6.48 0.33 3.33e-10 Inflammatory skin disease; LUSC cis rs5753037 0.803 rs131262 chr22:30133044 G/T cg11564601 chr22:30592435 NA 0.33 6.03 0.31 4.39e-9 Type 1 diabetes; LUSC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg20406979 chr6:167373233 NA -0.26 -6.16 -0.32 2.1e-9 Crohn's disease; LUSC cis rs7917772 0.582 rs10883744 chr10:104347247 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg17971929 chr21:40555470 PSMG1 0.74 12.01 0.55 7.27e-28 Cognitive function; LUSC cis rs1865760 1.000 rs3752421 chr6:25918688 G/A cg16482183 chr6:26056742 HIST1H1C 0.44 6.49 0.33 3.11e-10 Height; LUSC trans rs10845606 0.581 rs11055015 chr12:12836679 T/G cg15834202 chr5:58865918 PDE4D 0.37 5.97 0.31 6.13e-9 Systemic lupus erythematosus; LUSC cis rs6456156 0.586 rs12527827 chr6:167469271 C/T cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs9527 0.668 rs7092815 chr10:104736345 G/T cg04362960 chr10:104952993 NT5C2 0.61 9.23 0.45 3.16e-18 Arsenic metabolism; LUSC cis rs2290159 0.848 rs6771385 chr3:12639419 A/G cg23032965 chr3:12705835 RAF1 0.54 7.01 0.36 1.32e-11 Cholesterol, total; LUSC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs2073300 0.609 rs6132610 chr20:23403987 C/T cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg11798132 chr1:224302585 FBXO28 0.35 6.53 0.34 2.43e-10 Tuberculosis; LUSC cis rs7202877 0.706 rs247436 chr16:75445971 T/G cg03315344 chr16:75512273 CHST6 -0.44 -6.3 -0.33 9.59e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.14e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg24675658 chr1:53192096 ZYG11B 0.72 12.03 0.55 6.08e-28 Monocyte count; LUSC trans rs61931739 0.635 rs3937819 chr12:33942715 A/G cg26384229 chr12:38710491 ALG10B 0.51 7.63 0.39 2.43e-13 Morning vs. evening chronotype; LUSC cis rs12922317 0.964 rs12930612 chr16:12072203 G/A cg08843971 chr16:11963173 GSPT1 -0.39 -5.85 -0.3 1.18e-8 Schizophrenia; LUSC cis rs113835537 0.529 rs4930378 chr11:66255515 T/C cg24851651 chr11:66362959 CCS 0.54 8.14 0.41 7.86e-15 Airway imaging phenotypes; LUSC cis rs10751667 0.666 rs10794347 chr11:939863 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.42 0.33 4.63e-10 Alzheimer's disease (late onset); LUSC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg15445000 chr17:37608096 MED1 0.39 6.63 0.34 1.37e-10 Glomerular filtration rate (creatinine); LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg06600287 chr1:53387719 ECHDC2 -0.3 -6.28 -0.33 1.04e-9 Monocyte count; LUSC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg12615879 chr12:58013172 SLC26A10 -0.29 -5.94 -0.31 7.18e-9 Multiple sclerosis; LUSC cis rs9326248 0.861 rs7120449 chr11:117042899 T/C cg26566898 chr11:117069891 TAGLN 0.39 6.28 0.32 1.08e-9 Blood protein levels; LUSC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.14 0.45 6.13e-18 Height; LUSC cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg05985134 chr18:33552581 C18orf21 0.52 7.04 0.36 1.13e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs870825 0.655 rs1527870 chr4:185616631 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.5 0.59 1.86e-33 Blood protein levels; LUSC cis rs7246657 0.943 rs4803229 chr19:37864682 T/G cg23950597 chr19:37808831 NA -0.62 -7.63 -0.39 2.54e-13 Coronary artery calcification; LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg05665937 chr4:1216051 CTBP1 0.39 6.26 0.32 1.2e-9 Obesity-related traits; LUSC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg25258033 chr6:167368657 RNASET2 -0.45 -7.49 -0.38 6.31e-13 Crohn's disease; LUSC cis rs8072100 0.744 rs34537623 chr17:45530203 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.91 -0.31 8.45e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6964587 0.839 rs11767135 chr7:91551245 T/G cg17063962 chr7:91808500 NA -0.53 -8.18 -0.41 6.03e-15 Breast cancer; LUSC cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg11244672 chr19:19639970 YJEFN3 -0.62 -7.61 -0.38 2.76e-13 Bipolar disorder; LUSC cis rs6582630 0.598 rs10880614 chr12:38509766 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.24 -0.41 4e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs75804782 0.521 rs56176151 chr2:239440220 T/C cg18131467 chr2:239335373 ASB1 -0.7 -6.01 -0.31 4.98e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs11955175 1.000 rs75929994 chr5:40821816 T/C cg05478818 chr5:40835740 RPL37 0.75 5.83 0.3 1.28e-8 Bipolar disorder and schizophrenia; LUSC cis rs2797160 1.000 rs1739373 chr6:126011509 A/G cg05901451 chr6:126070800 HEY2 0.57 8.52 0.42 5.41e-16 Endometrial cancer; LUSC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg07424592 chr7:64974309 NA 0.7 6.15 0.32 2.24e-9 Diabetic kidney disease; LUSC cis rs35146811 0.555 rs2527898 chr7:99534030 C/G cg22906224 chr7:99728672 NA 0.43 5.8 0.3 1.56e-8 Coronary artery disease; LUSC cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg03146154 chr1:46216737 IPP -0.54 -8.28 -0.41 3.05e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2274273 0.837 rs59871474 chr14:55779363 T/C cg04306507 chr14:55594613 LGALS3 0.54 12.05 0.55 5.23e-28 Protein biomarker; LUSC cis rs4478037 1.000 rs4074416 chr3:33161729 A/G cg19404215 chr3:33155277 CRTAP 0.96 10.11 0.48 4.01e-21 Major depressive disorder; LUSC cis rs9815354 1.000 rs7632387 chr3:41853161 C/T cg03022575 chr3:42003672 ULK4 0.55 6.17 0.32 1.94e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs11155671 0.530 rs9383914 chr6:150207234 T/G cg13206674 chr6:150067644 NUP43 0.43 6.56 0.34 2.01e-10 Testicular germ cell tumor; LUSC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11890956 chr21:40555474 PSMG1 -0.74 -11.3 -0.53 2.67e-25 Menarche (age at onset); LUSC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg18302933 chr2:88491318 NA -0.39 -7.41 -0.38 1.07e-12 Response to metformin (IC50); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23018242 chr22:31608245 LIMK2 -0.39 -6.79 -0.35 5.27e-11 Electrocardiographic conduction measures; LUSC cis rs2692947 0.740 rs11695514 chr2:96548068 C/T cg22654517 chr2:96458247 NA 0.35 6.51 0.34 2.78e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7103648 0.897 rs11606287 chr11:47407439 C/A cg20307385 chr11:47447363 PSMC3 0.92 15.86 0.66 1.26e-42 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs2404602 0.679 rs12908421 chr15:76881794 T/G cg22467129 chr15:76604101 ETFA -0.45 -7.22 -0.37 3.44e-12 Blood metabolite levels; LUSC cis rs7772486 0.875 rs2073287 chr6:146350264 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.22 -0.37 3.52e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.77 -0.43 9.4e-17 Bipolar disorder; LUSC cis rs11190604 0.945 rs11190573 chr10:102233172 T/C cg16342193 chr10:102329863 NA -0.35 -6.24 -0.32 1.32e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg26384229 chr12:38710491 ALG10B 0.92 17.78 0.7 3e-50 Heart rate; LUSC cis rs10089 1.000 rs4835941 chr5:127430905 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.33 0.56 4.73e-29 Ileal carcinoids; LUSC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.55 0.34 2.17e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg12927641 chr6:109611667 NA -0.35 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs3087591 0.690 rs12103621 chr17:29607235 T/A cg24425628 chr17:29625626 OMG;NF1 -0.63 -9.03 -0.44 1.43e-17 Hip circumference; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg07157834 chr1:205819609 PM20D1 0.98 21.45 0.76 8.76e-65 Menarche (age at onset); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02275878 chr17:72919391 OTOP2;USH1G -0.39 -6.15 -0.32 2.17e-9 Triglycerides; LUSC cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.51 5.76 0.3 1.93e-8 Schizophrenia; LUSC cis rs9660992 1.000 rs3851296 chr1:205253839 A/C cg21643547 chr1:205240462 TMCC2 -0.47 -9.08 -0.45 9.57e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2070488 0.662 rs7375040 chr3:38469116 A/G cg24069376 chr3:38537580 EXOG 0.36 6.47 0.33 3.53e-10 Electrocardiographic conduction measures; LUSC cis rs5769707 0.568 rs2011097 chr22:50018069 A/G cg20744362 chr22:50050164 C22orf34 0.39 7.35 0.37 1.52e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3859192 0.599 rs2227319 chr17:38170845 G/A cg17467752 chr17:38218738 THRA -0.51 -7.18 -0.37 4.51e-12 White blood cell count; LUSC cis rs1728785 1.000 rs1749793 chr16:68569312 C/T cg02972257 chr16:68554789 NA -0.5 -6.36 -0.33 6.76e-10 Ulcerative colitis; LUSC cis rs2011503 0.941 rs4808934 chr19:19370917 C/T cg11584989 chr19:19387371 SF4 0.6 7.33 0.37 1.78e-12 Bipolar disorder; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg08470875 chr2:26401718 FAM59B -0.64 -8.86 -0.44 4.7e-17 Gut microbiome composition (summer); LUSC cis rs6940638 0.688 rs9295730 chr6:27128806 T/C cg09904177 chr6:26538194 HMGN4 -0.48 -6.97 -0.36 1.65e-11 Intelligence (multi-trait analysis); LUSC cis rs6138458 0.847 rs56312312 chr20:24959386 C/A cg26195577 chr20:24973756 C20orf3 1.12 17.61 0.69 1.5e-49 Blood protein levels; LUSC trans rs10885582 0.818 rs11196793 chr10:116346929 T/C cg01002288 chr1:43166549 YBX1 -0.36 -6.21 -0.32 1.59e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.67 0.65 7.43e-42 Bladder cancer; LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg13047869 chr3:10149882 C3orf24 0.58 7.94 0.4 3.03e-14 Alzheimer's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14136810 chr15:40213326 GPR176 -0.47 -6.11 -0.32 2.79e-9 Bipolar disorder and schizophrenia; LUSC trans rs11250098 0.541 rs6997997 chr8:10766082 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -6.9 -0.35 2.58e-11 Morning vs. evening chronotype; LUSC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg10792982 chr14:105748885 BRF1 0.5 9.2 0.45 3.93e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs7804356 1.000 rs6964094 chr7:26834380 C/G cg03456212 chr7:26904342 SKAP2 -0.55 -6.58 -0.34 1.86e-10 Type 1 diabetes; LUSC trans rs61931739 0.500 rs9705909 chr12:34576419 G/C cg26384229 chr12:38710491 ALG10B 0.9 15.32 0.64 1.65e-40 Morning vs. evening chronotype; LUSC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.08 14.84 0.63 1.3e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504073 0.647 rs1511359 chr8:50006448 T/A cg00325661 chr8:49890786 NA 0.62 9.96 0.48 1.27e-20 Blood metabolite ratios; LUSC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs1577917 0.958 rs3900313 chr6:86537154 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.6 0.38 3.01e-13 Multiple sclerosis; LUSC trans rs79976124 0.760 rs74295030 chr6:66654441 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 9.13 0.45 6.87e-18 Type 2 diabetes; LUSC cis rs2404602 0.735 rs62028423 chr15:76754514 G/A cg23625390 chr15:77176239 SCAPER -0.6 -9.47 -0.46 5.24e-19 Blood metabolite levels; LUSC trans rs6598955 0.671 rs10159433 chr1:26618370 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.76 -0.43 9.89e-17 Obesity-related traits; LUSC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg22532475 chr10:104410764 TRIM8 -0.3 -6.61 -0.34 1.55e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs11039798 0.557 rs4436575 chr11:48398894 T/C cg03929089 chr4:120376271 NA -0.59 -6.27 -0.32 1.13e-9 Axial length; LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs7617773 0.817 rs9853804 chr3:48327729 T/C cg11946769 chr3:48343235 NME6 0.86 13.87 0.6 7.36e-35 Coronary artery disease; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg16103275 chr6:290800 DUSP22 0.42 7.07 0.36 9e-12 Menopause (age at onset); LUSC cis rs654950 0.934 rs641974 chr1:42002137 G/A cg06885757 chr1:42089581 HIVEP3 -0.43 -8.17 -0.41 6.54e-15 Airway imaging phenotypes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17625409 chr5:72143790 TNPO1 -0.44 -6.07 -0.32 3.45e-9 Hepatitis; LUSC cis rs17270561 0.609 rs4131670 chr6:25738619 T/C cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg03433033 chr1:76189801 ACADM 0.88 19.03 0.72 3.22e-55 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11190604 1.000 rs2495759 chr10:102320363 C/T cg16342193 chr10:102329863 NA -0.39 -6.2 -0.32 1.69e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg13010199 chr12:38710504 ALG10B 0.69 10.65 0.5 5.27e-23 Bladder cancer; LUSC cis rs2637266 1.000 rs12784382 chr10:78378348 G/T cg18941641 chr10:78392320 NA 0.38 6.83 0.35 4.1e-11 Pulmonary function; LUSC cis rs6845621 0.901 rs4269172 chr4:18901705 G/A cg12196642 chr4:18937545 NA -0.34 -6.46 -0.33 3.79e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs4356932 0.817 rs6826406 chr4:76973557 A/C cg00809888 chr4:76862425 NAAA 0.35 5.82 0.3 1.37e-8 Blood protein levels; LUSC cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg13334819 chr7:99746414 C7orf59 -0.44 -5.84 -0.3 1.21e-8 Coronary artery disease; LUSC trans rs7181230 1.000 rs28534747 chr15:40374269 T/C cg22705835 chr10:65332833 REEP3 -0.4 -6.77 -0.35 5.87e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs6500395 1.000 rs12599028 chr16:48713082 C/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7590368 0.673 rs56147885 chr2:10937095 T/A cg15705551 chr2:10952987 PDIA6 0.52 5.79 0.3 1.66e-8 Educational attainment (years of education); LUSC cis rs2455601 1.000 rs11042108 chr11:8906021 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.5 -7.66 -0.39 2e-13 Schizophrenia; LUSC trans rs9886428 1.000 rs10099853 chr8:14115675 G/C cg11959399 chr20:741723 C20orf54 -0.4 -6.45 -0.33 3.98e-10 IgG glycosylation; LUSC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg11812906 chr14:75593930 NEK9 -0.64 -11.16 -0.52 8.32e-25 Height; LUSC cis rs4588572 0.645 rs10059940 chr5:77680873 T/C cg11547950 chr5:77652471 NA 0.53 7.57 0.38 3.75e-13 Triglycerides; LUSC cis rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05901451 chr6:126070800 HEY2 -0.78 -13.87 -0.6 7.18e-35 Brugada syndrome; LUSC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg05623727 chr3:50126028 RBM5 0.35 6.7 0.34 8.72e-11 Body mass index; LUSC cis rs7192380 1.000 rs11640319 chr16:69633515 G/A cg26679644 chr16:69762563 NA 0.35 6.23 0.32 1.44e-9 Sjögren's syndrome; LUSC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg03352830 chr11:487213 PTDSS2 0.76 9.12 0.45 7.38e-18 Body mass index; LUSC cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.84 0.51 1.13e-23 Schizophrenia; LUSC cis rs2898290 0.622 rs7822109 chr8:11349147 T/C cg27411982 chr8:10470053 RP1L1 -0.42 -6.85 -0.35 3.55e-11 Systolic blood pressure; LUSC cis rs6542838 0.641 rs6757098 chr2:99471399 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.0 -0.31 5.03e-9 Fear of minor pain; LUSC cis rs208520 0.690 rs207740 chr6:66764132 T/G cg07460842 chr6:66804631 NA 1.1 17.25 0.69 3.83e-48 Exhaled nitric oxide output; LUSC cis rs11039100 0.850 rs11039164 chr11:5843138 C/T cg05234568 chr11:5960015 NA -0.51 -5.81 -0.3 1.46e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs926938 0.505 rs2878573 chr1:115521602 A/G cg12756093 chr1:115239321 AMPD1 0.46 7.0 0.36 1.43e-11 Autism; LUSC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg23978390 chr7:1156363 C7orf50 0.42 6.06 0.31 3.63e-9 Longevity;Endometriosis; LUSC cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.72e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.5 -8.39 -0.42 1.35e-15 Lymphocyte counts; LUSC cis rs7715806 0.500 rs58968428 chr5:75004107 A/G cg19683494 chr5:74908142 NA 0.57 7.68 0.39 1.83e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs17155006 0.746 rs366690 chr7:107749880 T/G cg05962710 chr7:107745446 LAMB4 -0.35 -6.34 -0.33 7.62e-10 Pneumococcal bacteremia; LUSC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg15445000 chr17:37608096 MED1 0.38 6.5 0.34 2.95e-10 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18099408 chr3:52552593 STAB1 -0.4 -7.03 -0.36 1.19e-11 Bipolar disorder; LUSC trans rs9388451 0.626 rs1268074 chr6:126107791 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.73 -12.64 -0.57 3.51e-30 Brugada syndrome; LUSC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg14552801 chr7:65878734 NA 0.44 6.31 0.33 8.81e-10 Aortic root size; LUSC cis rs6087990 0.965 rs6058869 chr20:31348750 C/T cg13636640 chr20:31349939 DNMT3B 1.03 23.09 0.78 3.49e-71 Ulcerative colitis; LUSC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.03 -0.4 1.74e-14 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.580 rs36118148 chr12:38411812 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.22 -0.41 4.67e-15 Bladder cancer; LUSC cis rs936229 0.813 rs1378938 chr15:75096443 T/C cg14664628 chr15:75095509 CSK -1.01 -17.69 -0.7 7.27e-50 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs9329221 0.736 rs11249999 chr8:10251265 C/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.08 -0.32 3.21e-9 Neuroticism; LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg04025307 chr7:1156635 C7orf50 0.36 5.85 0.3 1.17e-8 Longevity;Endometriosis; LUSC cis rs921665 0.831 rs80283188 chr2:3199209 T/C cg02624386 chr2:3182749 NA -0.62 -6.09 -0.32 3.04e-9 World class endurance athleticism; LUSC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.61 0.5 7.35e-23 Monocyte percentage of white cells; LUSC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg00376283 chr12:123451042 ABCB9 0.68 8.6 0.43 3.1e-16 Neutrophil percentage of white cells; LUSC cis rs77741769 0.571 rs3897746 chr12:121324727 A/G cg02419362 chr12:121203948 SPPL3 0.45 8.39 0.42 1.35e-15 Mean corpuscular volume; LUSC cis rs977987 0.872 rs7206665 chr16:75475287 A/C cg03315344 chr16:75512273 CHST6 0.53 10.27 0.49 1.14e-21 Dupuytren's disease; LUSC cis rs11155671 0.530 rs4869763 chr6:150211684 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.76 -0.3 1.89e-8 Testicular germ cell tumor; LUSC cis rs660498 0.507 rs34354872 chr10:27735673 T/G cg04084786 chr10:27609163 NA 0.4 5.89 0.31 9.39e-9 Asthma (childhood onset); LUSC cis rs9462027 0.628 rs11757370 chr6:34760736 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC cis rs10186029 0.680 rs11689451 chr2:213937840 C/T cg08319019 chr2:214017104 IKZF2 0.55 8.02 0.4 1.75e-14 Systemic sclerosis; LUSC cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.37 0.42 1.61e-15 High light scatter reticulocyte count; LUSC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg18681998 chr4:17616180 MED28 0.87 16.28 0.67 2.73e-44 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7098414 0.511 rs12262228 chr10:82160425 C/T cg00277334 chr10:82204260 NA -0.6 -9.92 -0.48 1.64e-20 Post bronchodilator FEV1; LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.33 0.33 7.78e-10 Platelet count; LUSC cis rs7659604 0.935 rs73844280 chr4:122664687 G/A cg05802129 chr4:122689817 NA -0.37 -6.69 -0.34 9.68e-11 Type 2 diabetes; LUSC cis rs11031096 0.782 rs10767845 chr11:4156922 C/T cg18678763 chr11:4115507 RRM1 -0.54 -7.64 -0.39 2.31e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg03709012 chr19:19516395 GATAD2A 0.75 11.57 0.53 2.96e-26 Tonsillectomy; LUSC cis rs1864400 0.690 rs7098237 chr10:43740513 T/A cg02780029 chr10:43622663 RET 0.34 5.75 0.3 2.07e-8 Hirschsprung disease; LUSC cis rs6494488 0.500 rs72741327 chr15:64730822 G/C cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Coronary artery disease; LUSC cis rs78707713 0.560 rs55668536 chr10:71242655 A/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.39 -0.46 9.32e-19 Venous thromboembolism; LUSC cis rs1595825 0.735 rs57603546 chr2:198918524 C/A cg00982548 chr2:198649783 BOLL -0.57 -6.9 -0.35 2.65e-11 Ulcerative colitis; LUSC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg13918804 chr1:2043761 PRKCZ 0.26 5.65 0.3 3.44e-8 Height; LUSC cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.67 0.43 1.96e-16 Menopause (age at onset); LUSC cis rs7605827 0.930 rs7608831 chr2:15605029 A/G cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg01341218 chr17:43662625 NA 0.77 11.18 0.52 7.14e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg17279839 chr7:150038598 RARRES2 0.45 6.93 0.35 2.18e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2224391 1.000 rs2753247 chr6:5261987 A/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.72 -0.35 7.76e-11 Height; LUSC cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg11584989 chr19:19387371 SF4 0.67 7.76 0.39 1.05e-13 Bipolar disorder; LUSC cis rs7618501 1.000 rs34451146 chr3:49813013 C/T cg24110177 chr3:50126178 RBM5 -0.42 -6.72 -0.34 8.08e-11 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.27 0.49 1.13e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19710444 chr14:73360162 DPF3 -0.46 -6.05 -0.31 3.94e-9 Bipolar disorder and schizophrenia; LUSC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg24399712 chr22:39784796 NA -0.62 -11.39 -0.53 1.33e-25 Intelligence (multi-trait analysis); LUSC cis rs500891 0.525 rs1145902 chr6:84038531 A/G cg08257003 chr6:84140564 ME1 0.33 7.8 0.39 7.82e-14 Platelet-derived growth factor BB levels; LUSC cis rs568617 0.953 rs1151519 chr11:65645831 G/C cg19792802 chr11:65647270 CTSW -0.41 -6.28 -0.32 1.05e-9 Crohn's disease; LUSC trans rs877282 1.000 rs71494928 chr10:769134 A/G cg13042288 chr15:90349979 ANPEP -0.49 -7.01 -0.36 1.32e-11 Uric acid levels; LUSC cis rs8077889 0.750 rs72836564 chr17:41935064 G/A cg26893861 chr17:41843967 DUSP3 0.93 11.83 0.54 3.21e-27 Triglycerides; LUSC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg06008330 chr7:65541103 ASL -0.39 -5.91 -0.31 8.27e-9 Aortic root size; LUSC cis rs6504663 0.558 rs7627 chr17:48552154 G/C cg22571038 chr17:48585470 MYCBPAP 0.48 6.02 0.31 4.58e-9 Visceral fat; LUSC cis rs478304 0.580 rs11606947 chr11:65508237 A/C cg27068330 chr11:65405492 SIPA1 -0.77 -11.04 -0.52 2.38e-24 Acne (severe); LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg16362232 chr11:430036 ANO9 0.65 8.17 0.41 6.56e-15 Body mass index; LUSC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg13628971 chr7:2884303 GNA12 0.49 6.87 0.35 3.18e-11 Height; LUSC cis rs9486719 0.857 rs4486027 chr6:96911886 T/C cg06623918 chr6:96969491 KIAA0776 -0.83 -11.92 -0.55 1.51e-27 Migraine;Coronary artery disease; LUSC cis rs1957429 0.520 rs72625647 chr14:65344106 T/C cg23373153 chr14:65346875 NA -0.88 -8.06 -0.4 1.4e-14 Pediatric areal bone mineral density (radius); LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg01616529 chr11:638424 DRD4 -0.34 -5.98 -0.31 5.7e-9 Systemic lupus erythematosus; LUSC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg21862992 chr11:68658383 NA 0.51 8.15 0.41 7.21e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7495211 0.509 rs11247363 chr15:98623942 C/T cg25404375 chr15:99409942 IGF1R -0.38 -5.65 -0.3 3.44e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6424115 1.000 rs58035855 chr1:24165248 G/C cg15997130 chr1:24165203 NA -0.57 -9.33 -0.45 1.46e-18 Immature fraction of reticulocytes; LUSC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.63 -8.04 -0.4 1.6e-14 Lung function (FEV1/FVC); LUSC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg11584989 chr19:19387371 SF4 0.6 7.06 0.36 9.47e-12 Bipolar disorder; LUSC cis rs1775715 0.677 rs2491272 chr10:32186783 A/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.84 0.39 6.15e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg08470875 chr2:26401718 FAM59B -0.71 -9.6 -0.47 1.92e-19 Gut microbiome composition (summer); LUSC cis rs1461503 0.966 rs10892937 chr11:122841904 T/C cg27398637 chr11:122830231 C11orf63 -0.41 -6.53 -0.34 2.4e-10 Menarche (age at onset); LUSC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.08 16.38 0.67 1.13e-44 Age-related macular degeneration (geographic atrophy); LUSC cis rs8028313 0.731 rs13380201 chr15:67973665 A/G cg05925327 chr15:68127851 NA -0.39 -6.1 -0.32 2.89e-9 Obesity; LUSC cis rs8040855 0.627 rs11631548 chr15:85619248 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.4 -5.75 -0.3 2.02e-8 Bulimia nervosa; LUSC cis rs4356932 0.935 rs4129781 chr4:76959388 C/G cg00809888 chr4:76862425 NAAA 0.34 5.75 0.3 1.98e-8 Blood protein levels; LUSC trans rs12891047 0.966 rs12588401 chr14:68240948 T/C cg09439754 chr16:82129088 HSD17B2 0.32 5.98 0.31 5.65e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs477692 0.789 rs568166 chr10:131400088 G/A cg26102564 chr10:131424627 MGMT 0.46 7.05 0.36 1.03e-11 Response to temozolomide; LUSC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6484504 0.625 rs7112412 chr11:31370271 T/C cg06552810 chr11:31128660 NA 0.39 6.76 0.35 6.27e-11 Red blood cell count; LUSC cis rs6500602 0.893 rs4786490 chr16:4491190 C/T cg08645402 chr16:4508243 NA -0.5 -8.55 -0.42 4.51e-16 Schizophrenia; LUSC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs8113142 0.614 rs4804848 chr19:29139728 A/T cg04546413 chr19:29218101 NA 0.43 5.91 0.31 8.41e-9 Femoral neck bone geometry and menarche (age at onset); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T ch.3.55501R chr3:3184210 TRNT1 0.48 6.25 0.32 1.26e-9 Cognitive function;Information processing speed; LUSC cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.49 -6.81 -0.35 4.67e-11 Chronic sinus infection; LUSC cis rs7223966 0.921 rs7225092 chr17:61864005 G/T cg00945038 chr17:61921165 SMARCD2 0.4 6.06 0.31 3.64e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg06784218 chr1:46089804 CCDC17 -0.5 -10.06 -0.48 5.57e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg11752832 chr7:134001865 SLC35B4 0.52 7.99 0.4 2.24e-14 Mean platelet volume; LUSC cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg24562669 chr7:97807699 LMTK2 0.45 7.96 0.4 2.71e-14 Breast cancer; LUSC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.04 -0.31 4.11e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs2392780 0.536 rs606345 chr8:128334499 T/A cg10897648 chr18:56338258 MALT1 -0.41 -6.23 -0.32 1.4e-9 Breast cancer (early onset); LUSC cis rs56399783 0.901 rs55767077 chr7:2774608 C/T cg14895029 chr7:2775587 GNA12 0.53 5.8 0.3 1.51e-8 Childhood ear infection; LUSC cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg10978503 chr1:24200527 CNR2 -0.45 -10.71 -0.51 3.36e-23 Immature fraction of reticulocytes; LUSC cis rs2219968 1.000 rs11783780 chr8:78971571 A/T cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.37e-21 Electroencephalogram traits; LUSC cis rs4713675 0.565 rs942640 chr6:33686442 G/T cg14003231 chr6:33640908 ITPR3 0.29 5.75 0.3 2.04e-8 Plateletcrit; LUSC cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg15839431 chr19:19639596 YJEFN3 -0.59 -6.54 -0.34 2.37e-10 Bipolar disorder; LUSC cis rs4474465 1.000 rs10793319 chr11:78217237 G/A cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.56e-9 Alzheimer's disease (survival time); LUSC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg00484396 chr16:3507460 NAT15 -0.71 -12.24 -0.56 1.01e-28 Tuberculosis; LUSC cis rs929354 0.713 rs3802129 chr7:156965297 G/A cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs2637266 0.935 rs2583052 chr10:78403288 C/G cg18941641 chr10:78392320 NA 0.42 7.62 0.38 2.67e-13 Pulmonary function; LUSC cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg26769984 chr7:1090371 C7orf50 0.58 7.77 0.39 9.47e-14 Bronchopulmonary dysplasia; LUSC cis rs7727544 0.557 rs2897096 chr5:131486284 A/G cg14196790 chr5:131705035 SLC22A5 0.47 8.03 0.4 1.69e-14 Blood metabolite levels; LUSC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg05347473 chr6:146136440 FBXO30 -0.56 -9.57 -0.46 2.44e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs847577 0.587 rs34307903 chr7:97728449 C/A cg24562669 chr7:97807699 LMTK2 0.46 8.18 0.41 6.15e-15 Breast cancer; LUSC trans rs1486139 0.967 rs10238892 chr7:46281491 T/C cg17534202 chr9:96721102 NA -0.34 -5.96 -0.31 6.36e-9 Select biomarker traits; LUSC cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg03676636 chr4:99064102 C4orf37 0.34 6.06 0.31 3.77e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg21770322 chr7:97807741 LMTK2 0.4 7.01 0.36 1.31e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7568458 0.709 rs56819945 chr2:85755139 C/T cg02493740 chr2:85810744 VAMP5 -0.5 -8.57 -0.42 3.91e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs16976116 0.901 rs1061873 chr15:55496756 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1801251 1.000 rs12474040 chr2:233615345 T/G cg25237894 chr2:233734115 C2orf82 0.34 6.33 0.33 7.67e-10 Coronary artery disease; LUSC cis rs61931739 0.517 rs4931748 chr12:34140827 C/T cg06521331 chr12:34319734 NA -0.48 -7.83 -0.39 6.74e-14 Morning vs. evening chronotype; LUSC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.51 7.72 0.39 1.35e-13 Schizophrenia; LUSC trans rs2243480 1.000 rs7792391 chr7:65773429 A/G cg10756647 chr7:56101905 PSPH -0.86 -8.52 -0.42 5.52e-16 Diabetic kidney disease; LUSC cis rs2235642 0.691 rs2281235 chr16:1603535 T/C cg09025071 chr16:1593152 IFT140;TMEM204 0.3 6.63 0.34 1.37e-10 Coronary artery disease; LUSC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.66 9.28 0.45 2.18e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs3008870 1.000 rs2985824 chr1:67410171 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.9 -14.79 -0.63 2.07e-38 Lymphocyte percentage of white cells; LUSC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.0 0.44 1.74e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.15 -0.36 5.64e-12 Bipolar disorder; LUSC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg00343986 chr7:65444356 GUSB 0.42 6.38 0.33 5.92e-10 Aortic root size; LUSC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.57 0.34 1.97e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs2262909 0.853 rs56207853 chr19:22292357 C/T cg11619707 chr19:22235551 ZNF257 0.39 5.84 0.3 1.22e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs61931739 0.857 rs999715 chr12:34143253 G/C cg26384229 chr12:38710491 ALG10B 0.57 9.3 0.45 1.84e-18 Morning vs. evening chronotype; LUSC cis rs7927771 0.826 rs7925389 chr11:47466790 A/T cg20135002 chr11:47629003 NA -0.49 -7.52 -0.38 4.95e-13 Subjective well-being; LUSC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg14773178 chr5:1868261 NA 0.31 5.65 0.3 3.44e-8 Cardiovascular disease risk factors; LUSC cis rs735396 1.000 rs1169313 chr12:121442670 C/T cg02403541 chr12:121454288 C12orf43 -0.55 -7.95 -0.4 2.87e-14 N-glycan levels; LUSC cis rs7241530 0.636 rs72985797 chr18:75904096 C/T cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg19468946 chr17:37922297 IKZF3 -0.43 -6.82 -0.35 4.17e-11 Self-reported allergy; LUSC cis rs9486715 1.000 rs6905568 chr6:97066382 T/C cg06623918 chr6:96969491 KIAA0776 -0.85 -14.16 -0.61 5.78e-36 Headache; LUSC cis rs9398803 0.865 rs4422634 chr6:126806676 A/G cg19875578 chr6:126661172 C6orf173 0.41 6.03 0.31 4.43e-9 Male-pattern baldness; LUSC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg26441486 chr22:50317300 CRELD2 0.49 7.25 0.37 2.87e-12 Schizophrenia; LUSC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg01416388 chr22:39784598 NA -0.43 -6.73 -0.35 7.48e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.63 -0.34 1.39e-10 Menopause (age at onset); LUSC cis rs3741151 0.686 rs7125598 chr11:73160589 C/T cg17517138 chr11:73019481 ARHGEF17 -0.85 -8.2 -0.41 5.25e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2439831 1.000 rs2245790 chr15:43744457 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.23 0.52 5.01e-25 Lung cancer in ever smokers; LUSC cis rs7246657 0.943 rs9676967 chr19:37928089 G/C cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs1801251 0.929 rs12694917 chr2:233707611 C/T cg25237894 chr2:233734115 C2orf82 -0.35 -6.55 -0.34 2.18e-10 Coronary artery disease; LUSC cis rs780094 0.500 rs7570476 chr2:27784658 C/T cg27432699 chr2:27873401 GPN1 0.41 5.7 0.3 2.69e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs7833790 0.724 rs6473299 chr8:82676936 A/G cg27398817 chr8:82754497 SNX16 -0.63 -7.98 -0.4 2.44e-14 Diastolic blood pressure; LUSC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03517284 chr6:25882590 NA -0.51 -8.37 -0.42 1.6e-15 Intelligence (multi-trait analysis); LUSC cis rs12997796 0.503 rs4366909 chr2:87021001 G/A cg25203885 chr2:87302643 LOC285074 -0.58 -5.67 -0.3 3.16e-8 Schizophrenia; LUSC cis rs6061231 0.505 rs62199217 chr20:60929539 G/A cg06026331 chr20:60912101 LAMA5 0.57 6.77 0.35 5.65e-11 Colorectal cancer; LUSC cis rs2933343 0.700 rs1680778 chr3:128614185 A/C cg11901034 chr3:128598214 ACAD9 -0.41 -6.4 -0.33 5.17e-10 IgG glycosylation; LUSC cis rs6599077 1.000 rs9832724 chr3:40097569 C/G cg13683864 chr3:40499215 RPL14 -0.62 -7.54 -0.38 4.57e-13 Sleep-related phenotypes; LUSC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg16325326 chr1:53192061 ZYG11B 0.97 19.12 0.72 1.4e-55 Monocyte count; LUSC trans rs877282 0.797 rs11253329 chr10:753200 A/T cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg13395646 chr4:1353034 KIAA1530 -0.58 -9.15 -0.45 5.94e-18 Obesity-related traits; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg19648896 chr11:65337773 SSSCA1 0.72 6.67 0.34 1.06e-10 Body mass index; LUSC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.36 -6.23 -0.32 1.39e-9 Breast cancer; LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg08683831 chr4:1404607 NA 0.37 6.31 0.33 8.84e-10 Obesity-related traits; LUSC cis rs1949733 1.000 rs3103072 chr4:8508431 C/T cg13073564 chr4:8508604 NA 0.51 9.54 0.46 3.18e-19 Response to antineoplastic agents; LUSC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs1808579 0.904 rs6507708 chr18:21101456 C/A cg14672496 chr18:21087552 C18orf8 0.37 6.37 0.33 6.21e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs9650315 0.866 rs4636179 chr8:57186286 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg15017067 chr4:17643749 FAM184B 0.36 5.9 0.31 8.95e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11756438 0.572 rs2638545 chr6:119000203 G/C cg21191810 chr6:118973309 C6orf204 0.35 5.91 0.31 8.34e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7312933 0.584 rs6582395 chr12:42700141 T/C cg17420585 chr12:42539391 GXYLT1 -0.31 -5.88 -0.31 9.92e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs977987 0.527 rs62059844 chr16:75429737 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.02 -0.36 1.26e-11 Dupuytren's disease; LUSC cis rs7954584 0.583 rs10770186 chr12:122361412 A/G cg21016266 chr12:122356598 WDR66 0.54 7.69 0.39 1.62e-13 Mean corpuscular volume; LUSC cis rs7524258 0.903 rs763197 chr1:7289959 A/G cg07173049 chr1:7289937 CAMTA1 0.37 7.62 0.38 2.62e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs9462027 0.628 rs6942040 chr6:34761809 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.77 -0.3 1.84e-8 Systemic lupus erythematosus; LUSC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg05234568 chr11:5960015 NA -0.6 -8.58 -0.42 3.64e-16 DNA methylation (variation); LUSC cis rs7804356 0.906 rs17323934 chr7:26904330 C/G cg03456212 chr7:26904342 SKAP2 0.59 6.74 0.35 7.11e-11 Type 1 diabetes; LUSC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg12564285 chr5:131593104 PDLIM4 -0.46 -7.96 -0.4 2.8e-14 Breast cancer; LUSC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg27121462 chr16:89883253 FANCA 0.55 8.88 0.44 4.24e-17 Vitiligo; LUSC cis rs11785400 0.793 rs4587307 chr8:143738529 G/A cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs9296092 0.538 rs56199698 chr6:33534505 G/C cg13560919 chr6:33536144 NA -0.86 -16.62 -0.67 1.25e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7605827 0.930 rs3805103 chr2:15518352 A/G cg19274914 chr2:15703543 NA -0.47 -9.08 -0.44 9.76e-18 Educational attainment (years of education); LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.816 rs376742 chr20:25487417 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.81 16.69 0.67 6.38e-46 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg11578532 chr1:161008127 TSTD1 0.34 7.33 0.37 1.8e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7705502 0.855 rs17763083 chr5:173351488 C/T cg18693985 chr5:173351052 CPEB4 -0.38 -5.97 -0.31 6.06e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs2637266 1.000 rs2395394 chr10:78360679 G/C cg18941641 chr10:78392320 NA 0.39 7.12 0.36 6.84e-12 Pulmonary function; LUSC cis rs12681288 0.578 rs56702775 chr8:968860 G/A cg04851639 chr8:1020857 NA -0.39 -7.75 -0.39 1.14e-13 Schizophrenia; LUSC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg18306943 chr3:40428807 ENTPD3 0.36 5.8 0.3 1.51e-8 Renal cell carcinoma; LUSC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2559856 0.967 rs2695290 chr12:102087844 A/G cg12924262 chr12:102091054 CHPT1 -0.44 -6.18 -0.32 1.85e-9 Blood protein levels; LUSC cis rs2860975 1.000 rs10882514 chr10:96782898 T/C cg09036531 chr10:96991505 NA -0.41 -5.75 -0.3 2.06e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -7.96 -0.4 2.69e-14 Major depressive disorder; LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg13395646 chr4:1353034 KIAA1530 -0.66 -10.39 -0.49 4.22e-22 Obesity-related traits; LUSC trans rs1941687 0.563 rs9953034 chr18:31335294 A/G cg13755796 chr4:20253514 NA -0.38 -5.95 -0.31 6.64e-9 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg12832228 chr8:28244096 ZNF395 0.48 6.1 0.32 3.01e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11229555 0.645 rs36002376 chr11:58204809 C/G cg15696309 chr11:58395628 NA -0.67 -8.13 -0.41 8.64e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs11167764 1.000 rs7722567 chr5:141483178 C/T cg23435118 chr5:141488016 NDFIP1 -0.55 -7.75 -0.39 1.11e-13 Crohn's disease; LUSC cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg25233709 chr10:116636983 FAM160B1 0.44 7.92 0.4 3.62e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2073300 1.000 rs6137977 chr20:23464191 G/T cg12062639 chr20:23401060 NAPB 0.73 5.67 0.3 3.06e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3733585 0.631 rs3822236 chr4:10119961 T/G cg00071950 chr4:10020882 SLC2A9 -0.54 -8.63 -0.43 2.48e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs12439619 0.530 rs28883606 chr15:82509054 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.49 -8.15 -0.41 7.64e-15 Intelligence (multi-trait analysis); LUSC cis rs2294693 0.947 rs9381025 chr6:40986623 C/T cg14769373 chr6:40998127 UNC5CL -0.54 -8.33 -0.41 2.09e-15 Gastric cancer;Non-cardia gastric cancer; LUSC trans rs7698623 0.850 rs1381960 chr4:88801652 A/T cg27340350 chr19:49559583 CGB7 -0.66 -6.14 -0.32 2.33e-9 Cardiovascular disease risk factors; LUSC cis rs6840360 0.593 rs2089811 chr4:152685171 C/T cg22705602 chr4:152727874 NA 0.36 7.98 0.4 2.36e-14 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16659246 chr4:18023725 LCORL -0.39 -6.15 -0.32 2.2e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4718428 0.672 rs13241598 chr7:66300652 A/G cg18876405 chr7:65276391 NA 0.49 6.66 0.34 1.14e-10 Corneal structure; LUSC cis rs7312933 0.618 rs7954523 chr12:42681508 A/G cg17420585 chr12:42539391 GXYLT1 -0.33 -6.16 -0.32 2.08e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7223966 1.000 rs11657081 chr17:61792339 C/T cg11494091 chr17:61959527 GH2 0.34 5.69 0.3 2.83e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg08847533 chr14:75593920 NEK9 -0.84 -15.37 -0.64 1.12e-40 Height; LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02475777 chr4:1388615 CRIPAK 0.57 8.78 0.43 8.95e-17 Longevity; LUSC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg20607287 chr7:12443886 VWDE -0.64 -6.27 -0.32 1.09e-9 Coronary artery disease; LUSC cis rs12594515 0.904 rs8032875 chr15:45998010 A/C cg06207120 chr15:45996521 NA 0.39 6.04 0.31 4.12e-9 Waist circumference;Weight; LUSC cis rs2760061 0.583 rs3094911 chr1:228210179 A/G cg01973587 chr1:228161476 NA -0.35 -5.66 -0.3 3.33e-8 Diastolic blood pressure; LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg22535103 chr8:58192502 C8orf71 -0.58 -7.09 -0.36 7.87e-12 Developmental language disorder (linguistic errors); LUSC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.45 7.25 0.37 2.91e-12 Intelligence (multi-trait analysis); LUSC cis rs9329289 0.851 rs61835719 chr10:2543390 A/G cg15501526 chr10:2543763 NA 0.68 12.99 0.58 1.6e-31 Age-related hearing impairment; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 6.24 0.32 1.34e-9 Electroencephalogram traits; LUSC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.77 0.35 5.68e-11 Tonsillectomy; LUSC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.11 14.24 0.61 2.64e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7267979 0.932 rs1985737 chr20:25591468 T/A cg08601574 chr20:25228251 PYGB 0.38 5.67 0.3 3.11e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg05347473 chr6:146136440 FBXO30 0.51 8.52 0.42 5.43e-16 Lobe attachment (rater-scored or self-reported); LUSC trans rs2204008 0.744 rs11180504 chr12:38236313 C/T cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.38e-9 Bladder cancer; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg25767906 chr1:53392781 SCP2 -0.5 -9.27 -0.45 2.43e-18 Monocyte count; LUSC trans rs1997103 1.000 rs10279035 chr7:55412055 C/T cg20935933 chr6:143382018 AIG1 0.51 7.43 0.38 8.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9865818 0.754 rs7613192 chr3:188109833 C/G cg23651889 chr3:188115336 LPP -0.39 -6.01 -0.31 4.8e-9 Allergic sensitization; LUSC cis rs546131 0.928 rs546521 chr11:34824773 G/C cg06937548 chr11:34938143 PDHX;APIP 0.47 6.5 0.34 2.89e-10 Lung disease severity in cystic fibrosis; LUSC trans rs7824557 0.564 rs2736293 chr8:11234613 T/A cg15556689 chr8:8085844 FLJ10661 -0.5 -7.53 -0.38 4.7e-13 Retinal vascular caliber; LUSC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.91 0.31 8.29e-9 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.690 rs11191369 chr10:104457456 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.45 6.17 0.32 2.02e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2777491 0.574 rs316616 chr15:41746276 G/A cg18705301 chr15:41695430 NDUFAF1 -1.04 -21.14 -0.76 1.47e-63 Ulcerative colitis; LUSC cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.95 18.27 0.71 3.39e-52 Body mass index (adult); LUSC cis rs8099014 0.861 rs2277722 chr18:56121280 G/C cg12907477 chr18:56117327 MIR122 0.43 6.79 0.35 5.29e-11 Platelet count; LUSC cis rs12681287 0.640 rs7820234 chr8:87350950 A/C cg27223183 chr8:87520930 FAM82B -0.54 -7.06 -0.36 9.96e-12 Caudate activity during reward; LUSC cis rs2273669 0.667 rs1407241 chr6:109328432 G/A cg05315195 chr6:109294784 ARMC2 -0.53 -5.89 -0.31 9.28e-9 Prostate cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16857181 chr7:32931955 KBTBD2 0.44 6.0 0.31 5.06e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg15448220 chr1:150897856 SETDB1 0.41 5.96 0.31 6.29e-9 Melanoma; LUSC cis rs72634258 0.945 rs161800 chr1:8042402 A/T cg26816564 chr1:7831052 VAMP3 0.43 5.85 0.3 1.16e-8 Inflammatory bowel disease; LUSC cis rs6120849 0.754 rs1885116 chr20:33600560 A/G cg24642439 chr20:33292090 TP53INP2 0.6 6.67 0.34 1.05e-10 Protein C levels; LUSC cis rs3862030 0.810 rs5870 chr10:104239100 A/G cg05855489 chr10:104503620 C10orf26 0.48 7.3 0.37 2.16e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg18904891 chr8:8559673 CLDN23 0.59 8.16 0.41 7.1e-15 Obesity-related traits; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg24060327 chr5:131705240 SLC22A5 -0.68 -11.54 -0.53 3.83e-26 Breast cancer; LUSC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg10172584 chr19:19639581 YJEFN3 -0.46 -5.65 -0.3 3.42e-8 Bipolar disorder; LUSC cis rs6429082 0.791 rs61836205 chr1:235638753 C/G cg26050004 chr1:235667680 B3GALNT2 0.62 8.43 0.42 1.02e-15 Adiposity; LUSC cis rs2280018 0.963 rs4985147 chr16:15168760 T/C cg27102117 chr16:15229624 NA 0.41 7.08 0.36 8.32e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.83 0.47 3.48e-20 Electroencephalogram traits; LUSC cis rs35146811 0.700 rs2950520 chr7:99827148 T/C cg13334819 chr7:99746414 C7orf59 0.5 6.68 0.34 9.99e-11 Coronary artery disease; LUSC cis rs7100689 0.577 rs2236569 chr10:82043576 G/A cg00277334 chr10:82204260 NA -0.45 -6.24 -0.32 1.34e-9 Post bronchodilator FEV1; LUSC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg01193554 chr1:41846683 NA -0.29 -6.07 -0.32 3.53e-9 Intelligence (multi-trait analysis); LUSC cis rs7759001 0.817 rs9461380 chr6:27363557 G/T cg18711553 chr6:27366782 ZNF391 0.39 5.66 0.3 3.26e-8 Glomerular filtration rate (creatinine); LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg23758822 chr17:41437982 NA 1.05 19.6 0.73 1.82e-57 Menopause (age at onset); LUSC cis rs9535307 0.799 rs2146143 chr13:50245620 A/C cg04663916 chr13:50265991 EBPL 0.48 5.91 0.31 8.67e-9 Obesity-related traits; LUSC cis rs56161922 0.915 rs12562739 chr1:207856658 T/A cg11752769 chr1:207818423 CR1L -0.71 -6.0 -0.31 5.07e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.59 10.04 0.48 6.41e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg23711669 chr6:146136114 FBXO30 -0.91 -17.45 -0.69 6.37e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs9926296 0.632 rs7206546 chr16:89799079 C/T cg04287289 chr16:89883240 FANCA -0.5 -7.69 -0.39 1.68e-13 Vitiligo; LUSC cis rs1506636 1.000 rs60689684 chr7:123370403 C/T cg03229431 chr7:123269106 ASB15 0.63 9.98 0.48 1.08e-20 Plateletcrit;Platelet count; LUSC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg22875332 chr1:76189707 ACADM 0.75 10.31 0.49 8e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg02569458 chr12:86230093 RASSF9 0.62 10.52 0.5 1.55e-22 Major depressive disorder; LUSC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg09085632 chr11:111637200 PPP2R1B -1.07 -17.63 -0.69 1.25e-49 Primary sclerosing cholangitis; LUSC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg03676636 chr4:99064102 C4orf37 0.32 7.01 0.36 1.34e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs757081 0.667 rs7108067 chr11:17200220 G/A cg15432903 chr11:17409602 KCNJ11 -0.38 -5.89 -0.31 9.56e-9 Systolic blood pressure; LUSC cis rs908922 0.676 rs908927 chr1:152513338 C/G cg20991723 chr1:152506922 NA 0.53 10.03 0.48 7.05e-21 Hair morphology; LUSC cis rs8038465 0.615 rs62004616 chr15:73961176 C/T cg15420318 chr15:73925796 NPTN 0.61 10.63 0.5 6.22e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6456156 0.583 rs7748224 chr6:167456860 C/T cg06454157 chr6:167490870 NA -0.28 -6.72 -0.35 7.97e-11 Primary biliary cholangitis; LUSC cis rs12541635 0.966 rs12674846 chr8:107007178 A/G cg10147462 chr8:107024639 NA 0.55 9.97 0.48 1.16e-20 Age of smoking initiation; LUSC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg25456477 chr12:86230367 RASSF9 -0.4 -7.12 -0.36 6.59e-12 Major depressive disorder; LUSC trans rs2204008 0.837 rs2892296 chr12:37969785 C/T cg06521331 chr12:34319734 NA 0.4 6.35 0.33 6.91e-10 Bladder cancer; LUSC cis rs7927592 0.871 rs12941 chr11:68382193 C/T cg20283391 chr11:68216788 NA -0.6 -8.37 -0.42 1.6e-15 Total body bone mineral density; LUSC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg01017244 chr2:74357527 NA 0.72 14.21 0.61 3.6e-36 Gestational age at birth (maternal effect); LUSC cis rs9818941 0.824 rs7628186 chr3:157800499 T/C cg08654915 chr3:157813417 NA 0.32 7.52 0.38 5.11e-13 Height; LUSC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg01475377 chr6:109611718 NA -0.44 -7.84 -0.39 6.24e-14 Reticulocyte fraction of red cells; LUSC cis rs910316 0.763 rs6574205 chr14:75453039 G/C cg06637938 chr14:75390232 RPS6KL1 0.5 7.65 0.39 2.18e-13 Height; LUSC cis rs1505368 0.567 rs972491 chr2:213316573 A/G cg16329650 chr2:213403929 ERBB4 -0.57 -9.57 -0.46 2.49e-19 Symmetrical dimethylarginine levels; LUSC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg06108461 chr20:60628389 TAF4 0.95 14.84 0.63 1.32e-38 Body mass index; LUSC cis rs9388451 0.874 rs9398787 chr6:126090608 A/G cg05901451 chr6:126070800 HEY2 -0.94 -18.24 -0.71 4.57e-52 Brugada syndrome; LUSC cis rs10751667 0.714 rs7396700 chr11:963863 A/C ch.11.42038R chr11:967971 AP2A2 0.44 6.6 0.34 1.63e-10 Alzheimer's disease (late onset); LUSC cis rs2652834 0.519 rs4075584 chr15:63340292 C/T cg05507819 chr15:63340323 TPM1 0.99 12.37 0.56 3.46e-29 HDL cholesterol; LUSC cis rs1979679 0.573 rs7134807 chr12:28729250 A/G cg13890972 chr12:28721907 NA 0.39 5.71 0.3 2.54e-8 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg06221963 chr1:154839813 KCNN3 -0.59 -12.99 -0.58 1.61e-31 Prostate cancer; LUSC cis rs2970818 0.831 rs11063189 chr12:4588248 C/T cg11146114 chr12:4671731 NA -0.6 -5.69 -0.3 2.83e-8 Phosphorus levels; LUSC cis rs12586317 0.620 rs12437439 chr14:35585669 C/A cg16230307 chr14:35515116 FAM177A1 0.79 10.18 0.49 2.24e-21 Psoriasis; LUSC cis rs2204008 0.747 rs11514040 chr12:38201040 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.92 0.66 7.38e-43 Bladder cancer; LUSC cis rs12545109 0.842 rs10958482 chr8:57389331 G/T cg09654669 chr8:57350985 NA -0.51 -6.96 -0.36 1.85e-11 Obesity-related traits; LUSC cis rs7412746 0.611 rs2228099 chr1:150808889 C/G cg09365446 chr1:150670422 GOLPH3L 0.44 6.7 0.34 8.89e-11 Melanoma; LUSC cis rs9650315 0.852 rs5027177 chr8:57179659 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC cis rs2404602 0.684 rs62026898 chr15:76944371 C/A cg23625390 chr15:77176239 SCAPER -0.65 -10.08 -0.48 4.94e-21 Blood metabolite levels; LUSC cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg18252515 chr7:66147081 NA -1.21 -13.88 -0.6 6.79e-35 Diabetic kidney disease; LUSC trans rs941408 0.515 rs878893 chr19:2781325 A/G cg22153745 chr1:153894579 GATAD2B -0.52 -7.09 -0.36 7.86e-12 Total cholesterol levels; LUSC cis rs6733011 0.519 rs11900176 chr2:99463536 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.45 6.12 0.32 2.55e-9 Bipolar disorder; LUSC cis rs2692947 1.000 rs2692947 chr2:96674116 T/C cg22654517 chr2:96458247 NA 0.33 6.51 0.34 2.7e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7607369 0.714 rs4674334 chr2:219622811 T/C cg02176678 chr2:219576539 TTLL4 -0.7 -13.3 -0.59 1.09e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs1577917 0.958 rs34994386 chr6:86524135 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.47 -0.42 8.08e-16 Response to antipsychotic treatment; LUSC cis rs12950390 0.853 rs12451815 chr17:45855956 A/G cg06532163 chr17:45867833 NA 0.35 6.67 0.34 1.07e-10 IgG glycosylation; LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.68 0.34 9.71e-11 Menopause (age at onset); LUSC cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg03146154 chr1:46216737 IPP 0.53 7.79 0.39 8.74e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg20891283 chr12:69753455 YEATS4 0.81 14.65 0.63 7.13e-38 Blood protein levels; LUSC trans rs1005277 0.505 rs10827835 chr10:38150709 G/A cg17830980 chr10:43048298 ZNF37B 0.42 6.38 0.33 5.87e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg19077165 chr18:44547161 KATNAL2 0.45 6.67 0.34 1.04e-10 Personality dimensions; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14916095 chr14:52118110 FRMD6 0.46 6.28 0.32 1.08e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg23711669 chr6:146136114 FBXO30 -0.83 -14.87 -0.63 9.93e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs9868809 0.881 rs2286652 chr3:48689192 G/A cg00383909 chr3:49044727 WDR6 1.1 9.62 0.47 1.66e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2180341 0.532 rs6933893 chr6:127707250 A/G cg24812749 chr6:127587940 RNF146 0.64 9.44 0.46 6.68e-19 Breast cancer; LUSC cis rs11155671 0.530 rs6935829 chr6:150217811 C/T cg07701084 chr6:150067640 NUP43 0.46 6.86 0.35 3.28e-11 Testicular germ cell tumor; LUSC cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg23158103 chr7:148848205 ZNF398 -0.44 -6.81 -0.35 4.44e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg26314531 chr2:26401878 FAM59B -0.68 -9.19 -0.45 4.28e-18 Gut microbiome composition (summer); LUSC cis rs1577917 0.917 rs35283633 chr6:86690787 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.78 -0.43 8.45e-17 Response to antipsychotic treatment; LUSC cis rs11166629 0.785 rs894343 chr8:135612595 A/G cg27224718 chr8:135614730 ZFAT 0.64 10.14 0.49 3.11e-21 Smoking quantity; LUSC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.61 -6.04 -0.31 4.02e-9 Cerebrospinal P-tau181p levels; LUSC trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21659725 chr3:3221576 CRBN -0.6 -8.58 -0.42 3.59e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.19 0.41 5.6e-15 Prudent dietary pattern; LUSC cis rs425277 0.958 rs262652 chr1:2090816 T/C cg24578937 chr1:2090814 PRKCZ 0.6 13.87 0.6 7.21e-35 Height; LUSC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg13206674 chr6:150067644 NUP43 0.61 9.65 0.47 1.39e-19 Lung cancer; LUSC cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg00509249 chr6:109615579 CCDC162 -0.33 -5.95 -0.31 6.87e-9 Reticulocyte fraction of red cells; LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg15790184 chr11:494944 RNH1 0.5 7.7 0.39 1.52e-13 Systemic lupus erythematosus; LUSC cis rs7712401 0.601 rs246273 chr5:122280975 G/A cg19077854 chr5:122220652 SNX24 0.41 9.17 0.45 4.86e-18 Mean platelet volume; LUSC cis rs7582180 0.663 rs4850929 chr2:100990707 A/C cg12002119 chr2:101014098 CHST10 0.34 5.78 0.3 1.69e-8 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg12549451 chr6:135224345 NA 0.36 5.82 0.3 1.37e-8 Red blood cell count; LUSC trans rs4332037 1.000 rs4332037 chr7:1950809 C/T cg25206134 chr2:45395956 NA 0.55 6.32 0.33 8.54e-10 Bipolar disorder; LUSC cis rs7178572 0.568 rs8030074 chr15:77654232 C/T cg22256960 chr15:77711686 NA -0.51 -8.11 -0.41 9.91e-15 Type 2 diabetes; LUSC trans rs61931739 0.635 rs3937819 chr12:33942715 A/G cg13010199 chr12:38710504 ALG10B 0.4 6.04 0.31 4.15e-9 Morning vs. evening chronotype; LUSC cis rs447735 0.566 rs258337 chr16:89720710 T/A cg03605463 chr16:89740564 NA 0.57 9.26 0.45 2.58e-18 Hemoglobin concentration; LUSC cis rs748404 0.697 rs531910 chr15:43560607 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.33 0.41 2.18e-15 Lung cancer; LUSC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -6.76 -0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs12310956 0.532 rs1906134 chr12:33957135 A/C cg26384229 chr12:38710491 ALG10B 0.75 11.78 0.54 5.09e-27 Morning vs. evening chronotype; LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg22968622 chr17:43663579 NA 1.13 19.59 0.73 1.97e-57 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9788682 0.747 rs2568499 chr15:78722359 T/C cg06917634 chr15:78832804 PSMA4 0.47 5.91 0.31 8.65e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg07701084 chr6:150067640 NUP43 0.54 8.12 0.41 8.98e-15 Lung cancer; LUSC cis rs9303401 0.659 rs66514313 chr17:56714057 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.61 0.6 7.09e-34 Cognitive test performance; LUSC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.5 0.34 2.96e-10 Lung cancer; LUSC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11644478 chr21:40555479 PSMG1 0.94 18.56 0.71 2.36e-53 Cognitive function; LUSC cis rs9549367 0.762 rs9549694 chr13:113870510 G/A cg18105134 chr13:113819100 PROZ -0.73 -10.88 -0.51 8.33e-24 Platelet distribution width; LUSC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg02931644 chr1:25747376 RHCE 0.33 6.04 0.31 4.11e-9 Erythrocyte sedimentation rate; LUSC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg17252645 chr8:143867129 LY6D -0.38 -6.49 -0.33 3.1e-10 Urinary tract infection frequency; LUSC cis rs78456975 1.000 rs11899027 chr2:1560414 G/C cg01028140 chr2:1542097 TPO -0.6 -8.23 -0.41 4.3e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs3020736 0.500 rs7364293 chr22:42506370 C/T cg04733989 chr22:42467013 NAGA -0.62 -9.72 -0.47 7.81e-20 Autism spectrum disorder or schizophrenia; LUSC trans rs61931739 0.817 rs1687002 chr12:34170263 T/C cg26384229 chr12:38710491 ALG10B 0.56 9.08 0.44 9.49e-18 Morning vs. evening chronotype; LUSC cis rs9837602 1.000 rs62285461 chr3:99767642 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.89 -0.31 9.61e-9 Breast cancer; LUSC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg09323728 chr8:95962352 TP53INP1 -0.4 -7.92 -0.4 3.44e-14 Type 2 diabetes; LUSC cis rs11711311 1.000 rs12736 chr3:113530211 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.56 0.34 2.05e-10 IgG glycosylation; LUSC cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg26384229 chr12:38710491 ALG10B 0.92 17.45 0.69 6.63e-49 Heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02711976 chr1:36023590 NCDN;KIAA0319L 0.48 8.24 0.41 3.86e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg02034447 chr16:89574710 SPG7 0.44 6.49 0.33 3.09e-10 Multiple myeloma (IgH translocation); LUSC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.64 0.3 3.56e-8 Self-reported allergy; LUSC cis rs4664308 0.935 rs17216980 chr2:160960932 G/A cg03641300 chr2:160917029 PLA2R1 -0.68 -11.56 -0.53 3.29e-26 Idiopathic membranous nephropathy; LUSC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg24531977 chr5:56204891 C5orf35 0.56 8.31 0.41 2.39e-15 Breast cancer;Breast cancer (early onset); LUSC cis rs10751667 0.961 rs7396670 chr11:929269 A/G cg01483505 chr11:975446 AP2A2 0.41 5.66 0.3 3.29e-8 Alzheimer's disease (late onset); LUSC cis rs6669919 0.553 rs7527603 chr1:211668090 G/A cg10512769 chr1:211675356 NA -0.3 -7.02 -0.36 1.28e-11 Intelligence (multi-trait analysis); LUSC cis rs754466 0.580 rs2579178 chr10:79529215 A/G cg17075019 chr10:79541650 NA 0.75 12.07 0.55 4.42e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg08109568 chr15:31115862 NA 0.75 11.16 0.52 8.76e-25 Huntington's disease progression; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg26708280 chr2:190649305 PMS1;ORMDL1 0.48 6.32 0.33 8.6e-10 Cognitive function;Information processing speed; LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg08088566 chr11:430123 ANO9 0.71 7.61 0.38 2.76e-13 Body mass index; LUSC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg18351406 chr4:77819688 ANKRD56 0.54 7.57 0.38 3.62e-13 Emphysema distribution in smoking; LUSC cis rs1322512 0.917 rs2038617 chr6:153009584 T/A cg27316956 chr6:152958899 SYNE1 0.37 6.27 0.32 1.09e-9 Tonometry; LUSC trans rs9650657 0.645 rs9969657 chr8:10515278 A/G cg15556689 chr8:8085844 FLJ10661 0.49 7.49 0.38 6.32e-13 Neuroticism; LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg04944784 chr2:26401820 FAM59B 0.78 11.16 0.52 8.66e-25 Gut microbiome composition (summer); LUSC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg06112835 chr11:68658793 MRPL21 0.5 7.69 0.39 1.64e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2797685 1.000 rs707466 chr1:7861600 C/A cg04725166 chr1:7887271 PER3 -0.45 -6.2 -0.32 1.64e-9 Crohn's disease; LUSC cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg08999081 chr20:33150536 PIGU -0.43 -7.86 -0.39 5.51e-14 Coronary artery disease; LUSC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.77 0.35 5.68e-11 Tonsillectomy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20659025 chr11:126173961 DCPS -0.45 -6.87 -0.35 3.24e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1005277 0.579 rs9418322 chr10:38377296 G/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.64 -0.47 1.44e-19 Extrinsic epigenetic age acceleration; LUSC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg26597838 chr10:835615 NA 1.22 16.23 0.66 4.4e-44 Eosinophil percentage of granulocytes; LUSC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg17541715 chr7:1216824 NA -0.36 -5.8 -0.3 1.54e-8 Longevity;Endometriosis; LUSC cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.17e-22 Bladder cancer; LUSC cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg19628046 chr18:33552617 C18orf21 0.52 6.32 0.33 8.18e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs11971779 0.625 rs2355784 chr7:139072493 G/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6867032 0.839 rs4314451 chr5:2001859 T/C cg26168224 chr5:2018326 NA -0.75 -13.18 -0.58 3.2e-32 Gut microbiome composition (winter); LUSC cis rs651907 0.617 rs797776 chr3:101610243 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.48 6.85 0.35 3.67e-11 Colorectal cancer; LUSC cis rs79349575 0.749 rs8182364 chr17:47018025 A/G cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC trans rs1728785 0.901 rs1728797 chr16:68570989 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs617219 0.853 rs4703773 chr5:78520556 C/T cg24856658 chr5:78533917 JMY -0.3 -6.03 -0.31 4.26e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs897080 0.515 rs786405 chr2:44710367 G/T cg00619915 chr2:44497795 NA -0.44 -6.35 -0.33 7.09e-10 Height; LUSC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg24250549 chr1:154909240 PMVK 0.44 6.76 0.35 6.35e-11 Prostate cancer; LUSC cis rs4919694 1.000 rs112809537 chr10:104670346 C/T cg04362960 chr10:104952993 NT5C2 1.15 13.39 0.59 5.24e-33 Arsenic metabolism; LUSC trans rs6600671 0.934 rs12060031 chr1:121243450 A/G cg00646200 chr1:148855367 NA -0.46 -7.2 -0.37 4.06e-12 Hip geometry; LUSC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg22875332 chr1:76189707 ACADM -0.85 -14.19 -0.61 4.47e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7577851 0.625 rs67052036 chr2:69599024 A/C cg10773587 chr2:69614142 GFPT1 0.56 6.23 0.32 1.44e-9 Parkinson's disease (age of onset); LUSC trans rs10802346 0.545 rs10924568 chr1:246385482 C/A cg22732515 chr19:44031385 ETHE1 0.63 10.46 0.5 2.5e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.56e-21 Bladder cancer; LUSC cis rs8103278 1.000 rs725660 chr19:46262286 C/A cg11657440 chr19:46296263 DMWD -0.75 -11.87 -0.54 2.31e-27 Coronary artery disease; LUSC trans rs2055729 0.645 rs12544019 chr8:9742578 T/C cg06636001 chr8:8085503 FLJ10661 0.55 6.94 0.36 2.04e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs2455601 0.608 rs11042104 chr11:8890924 C/G cg21881798 chr11:8931708 C11orf17;ST5 0.41 7.06 0.36 9.83e-12 Schizophrenia; LUSC cis rs2282300 1.000 rs12575085 chr11:30428262 G/T cg25418670 chr11:30344373 C11orf46 -0.48 -6.36 -0.33 6.79e-10 Morning vs. evening chronotype; LUSC cis rs2439831 0.681 rs540031 chr15:43608855 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.78 0.65 2.63e-42 Lung cancer in ever smokers; LUSC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg06494592 chr3:125709126 NA -0.52 -5.93 -0.31 7.44e-9 Blood pressure (smoking interaction); LUSC cis rs11711311 0.869 rs1026364 chr3:113370010 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -5.78 -0.3 1.73e-8 IgG glycosylation; LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.44 0.53 8.42e-26 Menopause (age at onset); LUSC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg21951975 chr1:209979733 IRF6 0.59 7.71 0.39 1.49e-13 Cleft lip with or without cleft palate; LUSC cis rs354225 0.544 rs10184128 chr2:54803816 A/G cg26097391 chr2:54893211 SPTBN1 0.44 6.68 0.34 9.77e-11 Schizophrenia; LUSC cis rs13082711 0.911 rs2887926 chr3:27494475 T/C cg02860705 chr3:27208620 NA 0.47 7.92 0.4 3.65e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs4363385 0.693 rs6690549 chr1:152930426 C/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.06 -0.36 9.7e-12 Inflammatory skin disease; LUSC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg19077165 chr18:44547161 KATNAL2 -0.38 -5.75 -0.3 1.98e-8 Personality dimensions; LUSC cis rs9611519 0.780 rs2284079 chr22:41658632 C/T cg03806693 chr22:41940476 POLR3H -0.59 -8.66 -0.43 2e-16 Neuroticism; LUSC cis rs9329221 0.527 rs4841352 chr8:10327590 A/C cg27411982 chr8:10470053 RP1L1 0.41 6.35 0.33 7.01e-10 Neuroticism; LUSC trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7589342 0.839 rs10192144 chr2:106439854 A/G cg16077055 chr2:106428750 NCK2 0.37 7.04 0.36 1.11e-11 Addiction; LUSC cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.43 0.42 1.04e-15 Colorectal cancer; LUSC cis rs7586879 0.929 rs6545807 chr2:25124358 C/T cg04586622 chr2:25135609 ADCY3 0.32 6.22 0.32 1.51e-9 Body mass index; LUSC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg08270630 chr22:50330655 NA 0.4 5.9 0.31 8.83e-9 Schizophrenia; LUSC cis rs3806843 1.000 rs1548699 chr5:140164918 T/C cg19875535 chr5:140030758 IK 0.47 7.66 0.39 2.01e-13 Depressive symptoms (multi-trait analysis); LUSC trans rs11039798 0.610 rs11530356 chr11:48836290 C/A cg15704280 chr7:45808275 SEPT13 0.78 7.48 0.38 6.75e-13 Axial length; LUSC cis rs7173743 0.756 rs8034804 chr15:79129600 C/T cg00540400 chr15:79124168 NA 0.36 6.36 0.33 6.71e-10 Coronary artery disease; LUSC trans rs75804782 0.641 rs57080728 chr2:239350487 T/C cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.11e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.46 0.59 2.76e-33 Platelet count; LUSC cis rs2562456 0.793 rs2650819 chr19:21638873 C/T cg00806126 chr19:22604979 ZNF98 0.38 5.94 0.31 6.99e-9 Pain; LUSC cis rs12681288 0.576 rs7002793 chr8:963467 T/C cg15309053 chr8:964076 NA 0.39 7.72 0.39 1.39e-13 Schizophrenia; LUSC cis rs1371867 0.846 rs1788197 chr8:101290928 T/C cg06636551 chr8:101224915 SPAG1 -0.39 -7.35 -0.37 1.49e-12 Atrioventricular conduction; LUSC cis rs73198271 0.531 rs112930476 chr8:8671551 G/A cg01851573 chr8:8652454 MFHAS1 0.65 8.41 0.42 1.23e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6964587 0.839 rs6950538 chr7:91417816 T/C cg22709100 chr7:91322751 NA 0.45 6.52 0.34 2.66e-10 Breast cancer; LUSC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg11663144 chr21:46675770 NA -0.41 -7.2 -0.37 4.09e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.07 -0.36 9.03e-12 Colorectal cancer; LUSC cis rs7804356 1.000 rs7804356 chr7:26891665 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.18 -0.32 1.92e-9 Type 1 diabetes; LUSC cis rs6696846 0.716 rs6593921 chr1:205062861 A/G cg00857998 chr1:205179979 DSTYK 0.61 9.77 0.47 5.35e-20 Red blood cell count; LUSC cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg25258033 chr6:167368657 RNASET2 -0.42 -7.02 -0.36 1.21e-11 Crohn's disease; LUSC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg21724239 chr8:58056113 NA 0.54 6.59 0.34 1.72e-10 Developmental language disorder (linguistic errors); LUSC cis rs656319 0.629 rs10111315 chr8:9865588 G/A cg27411982 chr8:10470053 RP1L1 -0.4 -6.36 -0.33 6.78e-10 Myopia (pathological); LUSC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg18876405 chr7:65276391 NA 0.54 8.31 0.41 2.44e-15 Aortic root size; LUSC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg12963246 chr6:28129442 ZNF389 0.38 5.85 0.3 1.16e-8 Cardiac Troponin-T levels; LUSC cis rs2721195 1.000 rs1871541 chr8:145681713 G/T cg15320075 chr8:145703422 NA -0.64 -10.96 -0.51 4.33e-24 Age at first birth; LUSC cis rs1801251 0.893 rs11687128 chr2:233608901 T/C cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.34 2.87e-10 Coronary artery disease; LUSC cis rs35146811 0.735 rs1138417 chr7:99807146 C/G cg13334819 chr7:99746414 C7orf59 0.44 5.85 0.3 1.2e-8 Coronary artery disease; LUSC cis rs9486719 1.000 rs10872018 chr6:97026429 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -10.12 -0.48 3.69e-21 Migraine;Coronary artery disease; LUSC cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg16405210 chr4:1374714 KIAA1530 -0.55 -8.52 -0.42 5.62e-16 Obesity-related traits; LUSC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.75e-10 Crohn's disease; LUSC cis rs11190604 1.000 rs3750626 chr10:102266316 C/T cg07080220 chr10:102295463 HIF1AN 0.69 9.23 0.45 3.27e-18 Palmitoleic acid (16:1n-7) levels; LUSC trans rs12310956 0.515 rs11052934 chr12:33970381 T/C cg13010199 chr12:38710504 ALG10B 0.48 7.37 0.37 1.34e-12 Morning vs. evening chronotype; LUSC trans rs11039798 0.920 rs61448762 chr11:48923756 G/A cg15704280 chr7:45808275 SEPT13 0.81 7.11 0.36 7.06e-12 Axial length; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg13047869 chr3:10149882 C3orf24 0.62 8.66 0.43 1.98e-16 Alzheimer's disease; LUSC cis rs1448094 0.813 rs6539942 chr12:86452969 T/C cg00310523 chr12:86230176 RASSF9 -0.37 -6.68 -0.34 9.84e-11 Major depressive disorder; LUSC cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg23711669 chr6:146136114 FBXO30 0.92 18.29 0.71 2.92e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs7715806 0.500 rs2307112 chr5:75003413 A/C cg19683494 chr5:74908142 NA 0.58 7.75 0.39 1.15e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs62400317 0.762 rs6909047 chr6:44998915 C/G cg18551225 chr6:44695536 NA -0.41 -6.55 -0.34 2.14e-10 Total body bone mineral density; LUSC cis rs4474465 0.920 rs10899535 chr11:78216237 G/A cg27205649 chr11:78285834 NARS2 0.5 5.77 0.3 1.8e-8 Alzheimer's disease (survival time); LUSC cis rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05901451 chr6:126070800 HEY2 0.6 9.47 0.46 5.17e-19 Endometrial cancer; LUSC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg11062466 chr8:58055876 NA 0.74 8.95 0.44 2.49e-17 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs12760731 0.720 rs67857740 chr1:178402250 A/G cg00404053 chr1:178313656 RASAL2 0.57 6.23 0.32 1.39e-9 Obesity-related traits; LUSC cis rs72960926 0.744 rs55784940 chr6:74923315 G/T cg03266952 chr6:74778945 NA -0.84 -7.01 -0.36 1.34e-11 Metabolite levels (MHPG); LUSC cis rs10740039 0.810 rs10740036 chr10:62365974 C/T cg18175470 chr10:62150864 ANK3 -0.47 -7.08 -0.36 8.72e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs60843830 0.661 rs11674325 chr2:105517 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.45 6.66 0.34 1.16e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1595825 0.838 rs7603283 chr2:198517592 A/G cg19156104 chr2:198669113 PLCL1 -0.46 -5.75 -0.3 2.02e-8 Ulcerative colitis; LUSC cis rs9419702 0.639 rs9419624 chr10:133534822 G/A cg23460707 chr10:133558971 NA 0.35 6.01 0.31 4.86e-9 Survival in rectal cancer; LUSC cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg21535247 chr6:8435926 SLC35B3 0.58 9.09 0.45 9.13e-18 Motion sickness; LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg08888203 chr3:10149979 C3orf24 0.61 8.29 0.41 2.8e-15 Alzheimer's disease; LUSC cis rs16854884 0.657 rs7637912 chr3:143749777 G/A cg06585982 chr3:143692056 C3orf58 0.5 7.91 0.4 3.89e-14 Economic and political preferences (feminism/equality); LUSC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg21775007 chr8:11205619 TDH -0.46 -6.84 -0.35 3.83e-11 Neuroticism; LUSC cis rs57502260 0.704 rs17149179 chr11:68351722 C/T cg20283391 chr11:68216788 NA -0.62 -5.87 -0.31 1.08e-8 Total body bone mineral density (age 45-60); LUSC trans rs3749237 0.964 rs11714957 chr3:49776178 C/T cg21659725 chr3:3221576 CRBN 0.63 8.92 0.44 3.14e-17 Resting heart rate; LUSC cis rs2840044 0.517 rs2124247 chr17:33885468 G/A cg05299278 chr17:33885742 SLFN14 0.35 7.91 0.4 3.8e-14 Response to radiotherapy in cancer (late toxicity); LUSC cis rs4343996 1.000 rs6980323 chr7:3356207 A/G cg21248987 chr7:3385318 SDK1 -0.39 -6.58 -0.34 1.83e-10 Motion sickness; LUSC cis rs67460515 0.563 rs6794882 chr3:160851849 G/A cg03342759 chr3:160939853 NMD3 -0.45 -6.33 -0.33 7.76e-10 Parkinson's disease; LUSC cis rs9768139 0.708 rs10262596 chr7:158114495 G/A cg06219351 chr7:158114137 PTPRN2 -0.54 -9.85 -0.47 2.89e-20 Calcium levels; LUSC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg18758796 chr5:131593413 PDLIM4 0.4 6.7 0.34 8.94e-11 Breast cancer; LUSC cis rs734999 0.588 rs2843402 chr1:2528682 T/C cg18854424 chr1:2615690 NA -0.49 -9.74 -0.47 6.6e-20 Ulcerative colitis; LUSC cis rs977987 0.806 rs11862582 chr16:75431295 T/C cg03315344 chr16:75512273 CHST6 0.48 9.04 0.44 1.31e-17 Dupuytren's disease; LUSC cis rs870825 0.929 rs72689262 chr4:185590950 C/G cg04058563 chr4:185651563 MLF1IP 0.83 11.29 0.53 2.87e-25 Blood protein levels; LUSC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg05872129 chr22:39784769 NA -0.59 -10.06 -0.48 5.52e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg27529037 chr20:44575021 PCIF1 -0.42 -7.38 -0.37 1.23e-12 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg25072359 chr17:41440525 NA 0.65 9.27 0.45 2.36e-18 Menopause (age at onset); LUSC cis rs2361718 0.527 rs7211994 chr17:78152514 A/G cg09238746 chr17:78121135 EIF4A3 0.48 6.87 0.35 3.21e-11 Yeast infection; LUSC cis rs3925075 1.000 rs3925075 chr16:31347748 C/T cg02846316 chr16:31340340 ITGAM -0.36 -6.68 -0.34 1e-10 IgA nephropathy; LUSC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC trans rs11098499 1.000 rs35643470 chr4:120184948 T/C cg25214090 chr10:38739885 LOC399744 0.46 6.7 0.34 8.76e-11 Corneal astigmatism; LUSC cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg02527881 chr3:46936655 PTH1R 0.39 6.85 0.35 3.66e-11 Colorectal cancer; LUSC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg18350739 chr11:68623251 NA -0.37 -6.36 -0.33 6.73e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11105298 0.891 rs1008764 chr12:89887649 T/C cg00757033 chr12:89920650 WDR51B 0.6 10.35 0.49 5.9e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2230307 0.536 rs2893426 chr1:100528200 G/T cg24955406 chr1:100503596 HIAT1 0.56 6.07 0.32 3.5e-9 Carotid intima media thickness; LUSC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg01416388 chr22:39784598 NA -0.42 -7.03 -0.36 1.16e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2820315 0.867 rs2644135 chr1:201856256 C/G cg10061532 chr1:201886748 LMOD1 -0.26 -5.79 -0.3 1.65e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg06656553 chr16:89960601 TCF25 -0.65 -5.7 -0.3 2.65e-8 Skin colour saturation; LUSC cis rs12618769 0.597 rs55934321 chr2:99099417 G/A cg10123293 chr2:99228465 UNC50 0.47 7.67 0.39 1.89e-13 Bipolar disorder; LUSC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg10356904 chr22:49881777 NA -0.3 -6.65 -0.34 1.21e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg19628046 chr18:33552617 C18orf21 0.5 5.98 0.31 5.74e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.68 0.3 2.94e-8 Menopause (age at onset); LUSC cis rs240764 0.658 rs1039030 chr6:101198707 G/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg01802117 chr1:53393560 SCP2 -0.39 -6.54 -0.34 2.27e-10 Monocyte count; LUSC cis rs7000551 0.689 rs2469753 chr8:22383225 T/C cg12081754 chr8:22256438 SLC39A14 0.43 6.5 0.34 2.86e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11608355 0.545 rs12819142 chr12:109896316 G/T cg05360138 chr12:110035743 NA 0.87 10.28 0.49 1.03e-21 Neuroticism; LUSC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg24879335 chr3:133465180 TF 0.46 8.02 0.4 1.78e-14 Iron status biomarkers; LUSC cis rs9902453 0.765 rs2264302 chr17:28057095 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.18 -0.52 7.56e-25 Coffee consumption (cups per day); LUSC cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg06060754 chr5:176797920 RGS14 0.56 7.88 0.4 4.55e-14 Urate levels in lean individuals; LUSC cis rs12291225 0.545 rs11023187 chr11:14345559 T/G cg05501817 chr11:14380813 RRAS2 -0.56 -9.31 -0.45 1.74e-18 Sense of smell; LUSC cis rs9644630 0.696 rs7828025 chr8:19314693 A/G cg06562184 chr8:19319451 CSGALNACT1 0.48 8.09 0.4 1.1e-14 Oropharynx cancer; LUSC cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg15549821 chr19:49342101 PLEKHA4 -0.51 -6.09 -0.32 3.09e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs16917546 0.967 rs10995243 chr10:64391208 G/C cg03961010 chr10:64397487 ZNF365 -0.43 -6.71 -0.34 8.26e-11 Basal cell carcinoma; LUSC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg13722127 chr7:150037890 RARRES2 0.42 6.64 0.34 1.29e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg22508957 chr16:3507546 NAT15 -0.73 -9.29 -0.45 2.05e-18 Tuberculosis; LUSC cis rs12738007 0.544 rs4654390 chr1:29439016 T/A cg01925633 chr1:29338769 EPB41 0.39 6.01 0.31 4.8e-9 Schizophrenia; LUSC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg24399712 chr22:39784796 NA -0.57 -9.32 -0.45 1.62e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg21984481 chr17:79567631 NPLOC4 -0.59 -11.42 -0.53 1.02e-25 Eye color traits; LUSC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -6.43 -0.33 4.33e-10 Neutrophil percentage of white cells; LUSC cis rs11105298 0.891 rs11105299 chr12:89877943 A/G cg00757033 chr12:89920650 WDR51B 0.6 10.35 0.49 5.9e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg16325326 chr1:53192061 ZYG11B 0.89 16.36 0.67 1.39e-44 Monocyte count; LUSC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg19717773 chr7:2847554 GNA12 -0.42 -7.69 -0.39 1.71e-13 Height; LUSC trans rs6502050 0.805 rs7406858 chr17:80080623 G/A cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs983392 0.678 rs4938931 chr11:60026613 G/T cg02771260 chr11:59836817 MS4A3 0.37 6.07 0.32 3.39e-9 Alzheimer's disease (late onset); LUSC cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.11e-14 Glomerular filtration rate (creatinine); LUSC cis rs11583043 1.000 rs6675353 chr1:101459625 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.27 0.32 1.11e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs2274273 0.624 rs4580079 chr14:55780366 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.7 0.47 9.23e-20 Protein biomarker; LUSC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg13798780 chr7:105162888 PUS7 0.57 6.23 0.32 1.39e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1882538 0.564 rs10488164 chr7:133106199 A/G cg10665199 chr7:133106180 EXOC4 0.54 7.66 0.39 2.05e-13 Intelligence (multi-trait analysis); LUSC cis rs1997103 1.000 rs6949244 chr7:55411301 C/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg24209194 chr3:40518798 ZNF619 0.44 5.85 0.3 1.18e-8 Renal cell carcinoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12721145 chr4:109571876 OSTC -0.48 -7.04 -0.36 1.08e-11 Bipolar disorder and schizophrenia; LUSC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6574644 1.000 rs1957543 chr14:81777074 G/A cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs9527 0.590 rs12414232 chr10:104914491 A/T cg04362960 chr10:104952993 NT5C2 0.62 9.75 0.47 6.31e-20 Arsenic metabolism; LUSC cis rs7647973 0.696 rs7100 chr3:49053219 A/G cg21141812 chr3:48556323 PFKFB4 0.35 6.11 0.32 2.8e-9 Menarche (age at onset); LUSC cis rs11690935 0.885 rs6727017 chr2:172766847 T/A cg13550731 chr2:172543902 DYNC1I2 -0.82 -13.22 -0.59 2.23e-32 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25756398 chr11:93474621 C11orf54;TAF1D -0.53 -6.73 -0.35 7.58e-11 Bipolar disorder and schizophrenia; LUSC cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg12219531 chr12:120966889 COQ5 0.6 8.0 0.4 2.13e-14 High light scatter reticulocyte count; LUSC cis rs9300255 0.639 rs941306 chr12:123715113 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.94 -0.31 7.31e-9 Neutrophil percentage of white cells; LUSC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg23262073 chr20:60523788 NA -0.47 -6.67 -0.34 1.08e-10 Body mass index; LUSC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg27541892 chr1:1571801 CDK11B -0.62 -10.14 -0.49 2.97e-21 Body mass index; LUSC trans rs853679 0.607 rs66886492 chr6:28089731 C/T cg01620082 chr3:125678407 NA -0.85 -7.21 -0.37 3.87e-12 Depression; LUSC cis rs10100465 0.961 rs10955822 chr8:118674331 C/G cg09430518 chr8:118662568 NA 0.3 5.79 0.3 1.59e-8 Leprosy; LUSC trans rs61931739 0.534 rs1387789 chr12:34056304 C/A cg13010199 chr12:38710504 ALG10B 0.53 7.95 0.4 2.88e-14 Morning vs. evening chronotype; LUSC cis rs7618501 1.000 rs3749241 chr3:49744392 A/G cg12257692 chr3:49977190 RBM6 -0.21 -5.83 -0.3 1.29e-8 Intelligence (multi-trait analysis); LUSC cis rs7202877 0.656 rs4888370 chr16:75308230 T/C cg04384234 chr16:75411784 CFDP1 -0.66 -9.05 -0.44 1.21e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.78 -14.15 -0.61 5.95e-36 Total body bone mineral density; LUSC trans rs62238980 0.614 rs1475996 chr22:32464980 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC trans rs10435719 0.902 rs7014580 chr8:11803262 C/G cg06636001 chr8:8085503 FLJ10661 0.53 7.89 0.4 4.37e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg14440974 chr22:39074834 NA -0.37 -6.08 -0.32 3.32e-9 Menopause (age at onset); LUSC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC cis rs10751667 0.643 rs10902245 chr11:953014 C/T ch.11.42038R chr11:967971 AP2A2 -0.41 -6.2 -0.32 1.67e-9 Alzheimer's disease (late onset); LUSC cis rs9457247 1.000 rs413232 chr6:167400972 G/A cg20406979 chr6:167373233 NA 0.26 6.13 0.32 2.5e-9 Crohn's disease; LUSC cis rs11098499 0.775 rs2002049 chr4:120257417 A/G cg09307838 chr4:120376055 NA 0.69 10.47 0.5 2.2e-22 Corneal astigmatism; LUSC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg20203395 chr5:56204925 C5orf35 -0.79 -10.3 -0.49 8.54e-22 Initial pursuit acceleration; LUSC trans rs4729127 0.708 rs17166230 chr7:94017794 G/C cg20086523 chr13:52378287 DHRS12 0.59 6.58 0.34 1.78e-10 Intelligence; LUSC cis rs9303401 0.659 rs35564417 chr17:56718286 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.61 0.6 7.09e-34 Cognitive test performance; LUSC trans rs3733585 0.699 rs11724510 chr4:9958583 C/T cg26043149 chr18:55253948 FECH -0.44 -6.8 -0.35 4.9e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs941408 0.515 rs1640265 chr19:2784405 C/T cg02580895 chr19:2754563 NA -0.45 -6.65 -0.34 1.19e-10 Total cholesterol levels; LUSC trans rs7615952 0.599 rs66532274 chr3:125731845 G/A cg07211511 chr3:129823064 LOC729375 -0.83 -11.93 -0.55 1.48e-27 Blood pressure (smoking interaction); LUSC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg18099408 chr3:52552593 STAB1 0.37 6.2 0.32 1.64e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00797602 chr14:39901757 FBXO33 -0.43 -6.43 -0.33 4.49e-10 Electrocardiographic conduction measures; LUSC cis rs9309473 0.519 rs7606947 chr2:73909818 C/T cg20560298 chr2:73613845 ALMS1 -0.4 -6.32 -0.33 8.42e-10 Metabolite levels; LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg07092213 chr7:1199455 ZFAND2A -0.53 -8.88 -0.44 4.15e-17 Longevity;Endometriosis; LUSC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.58 0.38 3.44e-13 Multiple sclerosis; LUSC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg11062466 chr8:58055876 NA 0.47 6.37 0.33 6.36e-10 Developmental language disorder (linguistic errors); LUSC cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg23173402 chr1:227635558 NA 0.54 6.65 0.34 1.18e-10 Major depressive disorder; LUSC cis rs1953600 0.754 rs2573348 chr10:81925785 C/T cg04850286 chr10:81895943 PLAC9 -0.35 -6.01 -0.31 4.91e-9 Sarcoidosis; LUSC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg16325326 chr1:53192061 ZYG11B 0.87 15.96 0.66 5.29e-43 Monocyte count; LUSC cis rs62400317 0.826 rs4400216 chr6:45237955 T/G cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.27 0.41 3.21e-15 Menarche (age at onset); LUSC cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg08975724 chr8:8085496 FLJ10661 0.46 6.65 0.34 1.23e-10 Mood instability; LUSC cis rs11098499 0.863 rs2306456 chr4:120472422 C/G cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs734999 0.505 rs10797439 chr1:2540364 G/A cg18932078 chr1:2524107 MMEL1 0.28 6.15 0.32 2.18e-9 Ulcerative colitis; LUSC cis rs73198271 0.813 rs56007835 chr8:8610026 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -6.1 -0.32 2.92e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg26380479 chr7:97908229 NA -0.29 -6.41 -0.33 4.85e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs2282300 1.000 rs12799529 chr11:30408552 T/C cg25418670 chr11:30344373 C11orf46 -0.49 -6.56 -0.34 2.08e-10 Morning vs. evening chronotype; LUSC cis rs751728 1.000 rs6925273 chr6:33732448 A/G cg25922239 chr6:33757077 LEMD2 0.55 8.19 0.41 5.74e-15 Crohn's disease; LUSC cis rs4648739 0.613 rs13303201 chr1:1903712 G/T cg03688085 chr1:1910585 KIAA1751 -0.6 -10.19 -0.49 2.1e-21 Severe influenza A (H1N1) infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26972058 chr5:134369900 PITX1 -0.41 -6.32 -0.33 8.58e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg01065977 chr19:18549689 ISYNA1 -0.23 -5.77 -0.3 1.77e-8 Breast cancer; LUSC cis rs17270561 0.609 rs9348692 chr6:25720812 A/G cg16482183 chr6:26056742 HIST1H1C 0.69 9.43 0.46 7.29e-19 Iron status biomarkers; LUSC cis rs6496667 0.509 rs57962570 chr15:90985596 C/G cg10434728 chr15:90938212 IQGAP1 0.32 6.04 0.31 4.04e-9 Rheumatoid arthritis; LUSC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg04518342 chr5:131593106 PDLIM4 0.33 5.75 0.3 1.98e-8 Breast cancer;Mosquito bite size; LUSC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg00409905 chr10:38381863 ZNF37A -0.38 -6.41 -0.33 4.91e-10 Extrinsic epigenetic age acceleration; LUSC cis rs79387448 0.638 rs6741230 chr2:103069631 C/T cg09003973 chr2:102972529 NA 0.98 9.8 0.47 4.24e-20 Gut microbiota (bacterial taxa); LUSC trans rs769111 0.812 rs2908734 chr7:12070537 A/G cg26383454 chr6:11104957 HERV-FRD;LOC221710 0.42 6.23 0.32 1.37e-9 Tourette syndrome; LUSC cis rs9325144 0.647 rs12227834 chr12:38849246 G/C cg13010199 chr12:38710504 ALG10B -0.49 -7.5 -0.38 5.96e-13 Morning vs. evening chronotype; LUSC cis rs10782582 0.593 rs11163967 chr1:76154185 T/C cg03433033 chr1:76189801 ACADM -0.45 -6.72 -0.35 7.63e-11 Daytime sleep phenotypes; LUSC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg02822958 chr2:46747628 ATP6V1E2 0.39 5.95 0.31 6.66e-9 Height; LUSC cis rs12530845 0.623 rs77454235 chr7:135341862 T/C cg23117316 chr7:135346802 PL-5283 -0.63 -9.65 -0.47 1.31e-19 Red blood cell traits; LUSC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg02527881 chr3:46936655 PTH1R -0.42 -7.62 -0.38 2.64e-13 Colorectal cancer; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg23758822 chr17:41437982 NA 1.03 19.58 0.73 2.08e-57 Menopause (age at onset); LUSC cis rs35306767 0.714 rs11250228 chr10:1074887 A/G cg26597838 chr10:835615 NA 0.59 7.72 0.39 1.36e-13 Eosinophil percentage of granulocytes; LUSC cis rs17001868 0.568 rs9611312 chr22:40734790 T/C cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs9905704 0.846 rs302877 chr17:56764018 G/A cg12560992 chr17:57184187 TRIM37 0.55 8.02 0.4 1.81e-14 Testicular germ cell tumor; LUSC cis rs2084881 0.521 rs1022088 chr17:46579790 T/A cg09704116 chr17:46666958 LOC404266 0.26 5.8 0.3 1.56e-8 Ovarian cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg24707616 chr17:16342815 NCRNA00188;SNORD49B;SNORD49A 0.45 6.36 0.33 6.45e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2458413 0.563 rs2458419 chr8:105337141 G/C cg04554929 chr8:105342491 NA -0.4 -7.22 -0.37 3.46e-12 Paget's disease; LUSC cis rs829880 0.789 rs1096146 chr12:98850966 A/G cg25150519 chr12:98850993 NA 0.69 11.16 0.52 8.77e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg06212747 chr3:49208901 KLHDC8B 0.44 6.03 0.31 4.22e-9 Parkinson's disease; LUSC cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg26384229 chr12:38710491 ALG10B 0.84 13.48 0.59 2.22e-33 Drug-induced liver injury (flucloxacillin); LUSC cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg05340658 chr4:99064831 C4orf37 0.68 11.43 0.53 8.93e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC trans rs62055045 0.528 rs7194638 chr16:71573818 A/G cg09088153 chr15:96890598 NA -0.41 -5.96 -0.31 6.4e-9 Schizophrenia; LUSC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.27 0.45 2.32e-18 Monocyte percentage of white cells; LUSC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg10802521 chr3:52805072 NEK4 -0.54 -8.7 -0.43 1.54e-16 Intelligence (multi-trait analysis); LUSC cis rs4443100 0.670 rs9612225 chr22:23406619 G/A cg14186256 chr22:23484241 RTDR1 0.54 6.95 0.36 1.88e-11 Serum parathyroid hormone levels; LUSC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg25258033 chr6:167368657 RNASET2 0.48 7.92 0.4 3.52e-14 Crohn's disease; LUSC cis rs644148 0.730 rs2117383 chr19:44978298 A/C cg15540054 chr19:45004280 ZNF180 0.46 6.14 0.32 2.35e-9 Personality dimensions; LUSC cis rs9420 0.528 rs11607122 chr11:57389737 G/A cg23127183 chr11:57508653 C11orf31 -0.46 -6.33 -0.33 7.94e-10 Schizophrenia; LUSC cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.75 0.35 6.52e-11 Systemic lupus erythematosus; LUSC trans rs150992 0.593 rs34496 chr5:98299516 A/T cg11769476 chr20:49410810 BCAS4 -0.31 -5.95 -0.31 6.72e-9 Body mass index; LUSC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg22907277 chr7:1156413 C7orf50 0.45 7.12 0.36 6.61e-12 Longevity;Endometriosis; LUSC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg22823121 chr1:150693482 HORMAD1 0.59 9.11 0.45 7.63e-18 Tonsillectomy; LUSC trans rs61931739 0.500 rs3924705 chr12:34557825 A/T cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs7572644 0.679 rs36035825 chr2:28018131 T/G cg27432699 chr2:27873401 GPN1 0.54 6.89 0.35 2.82e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg24642439 chr20:33292090 TP53INP2 -0.49 -7.36 -0.37 1.47e-12 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg19230755 chr7:65878503 NA -0.43 -5.94 -0.31 7.09e-9 Aortic root size; LUSC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2730245 0.527 rs62476462 chr7:158686619 A/G cg11984989 chr7:158649758 WDR60 1.12 13.43 0.59 3.46e-33 Height; LUSC trans rs853679 0.769 rs7752448 chr6:28301099 A/G cg01620082 chr3:125678407 NA -0.63 -6.22 -0.32 1.49e-9 Depression; LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.43 0.38 9.46e-13 Bipolar disorder; LUSC cis rs9807989 0.811 rs7608638 chr2:102970289 A/G cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs13089785 0.965 rs12488058 chr3:123599681 C/T cg02012769 chr3:123398346 MYLK 0.32 5.9 0.31 8.9e-9 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg06618935 chr21:46677482 NA -0.37 -7.45 -0.38 7.79e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs12210905 0.688 rs72843177 chr6:27367414 A/G cg14616345 chr9:133901267 LAMC3 -0.65 -5.95 -0.31 6.6e-9 Hip circumference adjusted for BMI; LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg25767906 chr1:53392781 SCP2 -0.65 -12.85 -0.58 5.69e-31 Monocyte count; LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg05665937 chr4:1216051 CTBP1 0.38 6.17 0.32 1.99e-9 Obesity-related traits; LUSC cis rs9653442 1.000 rs1160542 chr2:100832155 A/G cg07810366 chr2:100720526 AFF3 0.44 7.8 0.39 7.92e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg26441486 chr22:50317300 CRELD2 0.46 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.19 0.32 1.72e-9 Menopause (age at onset); LUSC cis rs1832871 0.672 rs9457345 chr6:158743098 A/G cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg15147215 chr3:52552868 STAB1 -0.34 -6.07 -0.32 3.55e-9 Bipolar disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12581662 chr19:36706085 ZNF565;ZNF146 -0.39 -6.02 -0.31 4.7e-9 Electrocardiographic conduction measures; LUSC cis rs4654899 0.865 rs7532667 chr1:21438239 A/G cg01072550 chr1:21505969 NA -0.45 -6.69 -0.34 9.24e-11 Superior frontal gyrus grey matter volume; LUSC cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg24006582 chr15:45444508 DUOX1 -0.61 -8.83 -0.44 5.89e-17 Uric acid levels; LUSC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg17366294 chr4:99064904 C4orf37 0.49 8.39 0.42 1.36e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs864537 0.622 rs1214598 chr1:167426424 C/T cg22356347 chr1:167427500 CD247 -0.33 -7.7 -0.39 1.56e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg21951975 chr1:209979733 IRF6 0.5 8.4 0.42 1.29e-15 Monobrow; LUSC cis rs2219968 1.000 rs11776951 chr8:78971578 G/C cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11122272 0.701 rs2790887 chr1:231523724 G/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs11758351 1.000 rs76329209 chr6:26196430 A/G cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC trans rs561341 0.883 rs6505274 chr17:30344581 G/T cg27661571 chr11:113659931 NA -0.59 -7.39 -0.37 1.16e-12 Hip circumference adjusted for BMI; LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg00814883 chr7:100076585 TSC22D4 -0.73 -9.85 -0.47 2.85e-20 Platelet count; LUSC trans rs11098499 0.866 rs7665125 chr4:120402079 G/T cg25214090 chr10:38739885 LOC399744 0.48 7.61 0.38 2.88e-13 Corneal astigmatism; LUSC trans rs2243480 1.000 rs34702770 chr7:65344823 T/C cg10756647 chr7:56101905 PSPH 0.87 8.39 0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs16937 0.711 rs10900461 chr1:205153208 C/T cg00857998 chr1:205179979 DSTYK 0.48 6.85 0.35 3.66e-11 Schizophrenia; LUSC cis rs11105298 0.891 rs10858896 chr12:89920184 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.42 -0.38 1.01e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs34779708 0.931 rs12767414 chr10:35390193 C/T cg04310649 chr10:35416472 CREM -0.41 -6.49 -0.33 3.19e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg24324837 chr19:49891574 CCDC155 0.55 7.59 0.38 3.25e-13 Multiple sclerosis; LUSC trans rs6601327 0.573 rs13278824 chr8:9646119 T/A cg08975724 chr8:8085496 FLJ10661 0.44 6.44 0.33 4.14e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs61935443 0.832 rs7308359 chr12:95272904 G/T cg21533806 chr12:95267307 NA 0.53 6.72 0.35 7.83e-11 Schizophrenia; LUSC cis rs9486719 0.843 rs2499797 chr6:96848669 C/T cg06623918 chr6:96969491 KIAA0776 0.77 9.16 0.45 5.26e-18 Migraine;Coronary artery disease; LUSC trans rs3733585 0.699 rs6844316 chr4:9958977 A/G cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7511006 1.000 rs17836662 chr22:50672154 A/G cg16473166 chr22:50639996 SELO -0.56 -7.79 -0.39 8.78e-14 Obesity-related traits; LUSC cis rs11696845 0.666 rs6103849 chr20:43365687 C/T cg25301532 chr20:43378953 KCNK15 -0.36 -6.45 -0.33 3.83e-10 Obesity-related traits; LUSC cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.42 0.69 8.19e-49 Chronic sinus infection; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg26354017 chr1:205819088 PM20D1 0.8 13.54 0.6 1.34e-33 Menarche (age at onset); LUSC cis rs9733 0.744 rs3754211 chr1:150951857 G/A cg04414720 chr1:150670196 GOLPH3L 0.44 6.99 0.36 1.52e-11 Tonsillectomy; LUSC trans rs6582630 0.519 rs8189561 chr12:38296178 G/A cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs4380275 1.000 rs6548253 chr2:773655 A/G cg21665850 chr2:731073 NA 0.41 6.72 0.35 7.74e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24990803 chr7:38948533 VPS41 -0.45 -6.82 -0.35 4.18e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg08280861 chr8:58055591 NA 0.57 6.48 0.33 3.34e-10 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg03146154 chr1:46216737 IPP -0.58 -8.39 -0.42 1.37e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg05347473 chr6:146136440 FBXO30 0.55 9.5 0.46 4.36e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs9952991 0.883 rs2542148 chr18:12777573 C/G cg23598886 chr18:12777645 NA 0.65 6.58 0.34 1.83e-10 Inflammatory skin disease; LUSC cis rs7180079 0.620 rs637748 chr15:64858492 A/G cg08069370 chr15:64387884 SNX1 0.51 5.72 0.3 2.34e-8 Monocyte count; LUSC cis rs6901250 0.851 rs6938235 chr6:117147946 G/T cg12892004 chr6:117198278 RFX6 0.43 8.22 0.41 4.65e-15 C-reactive protein levels; LUSC cis rs8179 0.761 rs42035 chr7:92239531 A/G cg15732164 chr7:92237376 CDK6 -0.47 -6.53 -0.34 2.42e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.37 7.77 0.39 1e-13 Hemoglobin concentration; LUSC cis rs7760535 0.826 rs3777905 chr6:111870588 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.83 -0.35 4.02e-11 Metabolic traits; LUSC cis rs6942756 1.000 rs10954226 chr7:128953095 T/G cg02491457 chr7:128862824 NA -0.49 -6.77 -0.35 5.69e-11 White matter hyperintensity burden; LUSC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.0 0.61 2.3e-35 Allergic disease (asthma, hay fever or eczema); LUSC cis rs17807624 0.964 rs13249843 chr8:11459018 G/T cg21175976 chr8:11421337 BLK 0.38 6.24 0.32 1.29e-9 Systemic lupus erythematosus; LUSC cis rs11610422 1.000 rs12823902 chr12:31414290 A/G cg14306366 chr12:31406441 NA -0.51 -6.27 -0.32 1.09e-9 Coronary artery disease; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg07092213 chr7:1199455 ZFAND2A -0.55 -8.39 -0.42 1.43e-15 Longevity;Endometriosis; LUSC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg24531977 chr5:56204891 C5orf35 -1.08 -15.81 -0.65 2.09e-42 Initial pursuit acceleration; LUSC cis rs7804356 1.000 rs7804620 chr7:26891831 T/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs13064411 0.696 rs869342 chr3:113226330 C/T cg18753928 chr3:113234510 CCDC52 -0.51 -7.93 -0.4 3.26e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs12681287 0.752 rs4282548 chr8:87270792 A/T cg27223183 chr8:87520930 FAM82B -0.47 -5.93 -0.31 7.48e-9 Caudate activity during reward; LUSC cis rs9814567 0.896 rs4435682 chr3:134344182 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.85 14.23 0.61 2.9e-36 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12824058 0.844 rs10744458 chr12:130805820 C/T cg26677194 chr12:130822605 PIWIL1 -0.54 -8.2 -0.41 5.11e-15 Menopause (age at onset); LUSC cis rs981844 0.712 rs1037650 chr4:154737657 G/A cg14289246 chr4:154710475 SFRP2 -0.45 -6.26 -0.32 1.15e-9 Response to statins (LDL cholesterol change); LUSC trans rs7726839 0.578 rs10080150 chr5:593160 C/T cg25482853 chr8:67687455 SGK3 -0.43 -6.6 -0.34 1.58e-10 Obesity-related traits; LUSC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg12365402 chr11:9010492 NRIP3 -0.43 -7.97 -0.4 2.56e-14 Hemoglobin concentration; LUSC cis rs2688608 0.967 rs72814394 chr10:75656325 C/T cg23231163 chr10:75533350 FUT11 -0.38 -6.21 -0.32 1.57e-9 Inflammatory bowel disease; LUSC cis rs9527 0.545 rs7915816 chr10:104881750 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs17270561 0.609 rs9348694 chr6:25753640 C/T cg16482183 chr6:26056742 HIST1H1C 0.64 9.13 0.45 6.51e-18 Iron status biomarkers; LUSC cis rs1577917 1.000 rs12196411 chr6:86779762 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.84 -0.35 3.73e-11 Response to antipsychotic treatment; LUSC trans rs9926296 0.712 rs258332 chr16:89727683 G/A cg13698153 chr12:118541722 VSIG10 -0.35 -5.99 -0.31 5.31e-9 Vitiligo; LUSC cis rs11039100 0.850 rs34818213 chr11:5834591 C/T cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs4332037 0.539 rs868754 chr7:2033780 G/C cg11693508 chr17:37793320 STARD3 0.6 6.93 0.35 2.14e-11 Bipolar disorder; LUSC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg24881330 chr22:46731750 TRMU 0.82 7.29 0.37 2.32e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.49 8.06 0.4 1.35e-14 IgG glycosylation; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15190599 chr6:26156487 HIST1H1E -0.47 -7.83 -0.39 6.48e-14 Electrocardiographic conduction measures; LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg22907277 chr7:1156413 C7orf50 0.72 7.67 0.39 1.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg01579765 chr21:45077557 HSF2BP -0.5 -10.51 -0.5 1.65e-22 Mean corpuscular volume; LUSC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.865 rs28753180 chr4:120405367 A/T cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.57e-25 Corneal astigmatism; LUSC cis rs870825 0.616 rs35533356 chr4:185639134 A/G cg04058563 chr4:185651563 MLF1IP 0.88 13.43 0.59 3.54e-33 Blood protein levels; LUSC trans rs8072100 0.790 rs3760371 chr17:45695914 T/C cg04995722 chr7:26192034 NFE2L3 0.42 6.59 0.34 1.67e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs77216612 0.835 rs10845621 chr12:12887977 C/T cg04607235 chr12:12878440 APOLD1 -0.94 -15.58 -0.65 1.56e-41 Lymphocyte counts; LUSC trans rs9929218 1.000 rs28660361 chr16:68800838 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.53 -0.53 4.11e-26 Colorectal cancer; LUSC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg15556689 chr8:8085844 FLJ10661 -0.58 -9.71 -0.47 8.52e-20 Mood instability; LUSC cis rs1577917 1.000 rs12204365 chr6:86700532 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.45 -0.42 9.25e-16 Response to antipsychotic treatment; LUSC cis rs6842047 0.706 rs4862666 chr4:187136307 A/G cg09526685 chr4:187126073 CYP4V2 0.54 5.87 0.31 1.03e-8 Blood protein levels; LUSC cis rs2274273 0.905 rs10134800 chr14:55635209 A/G cg04306507 chr14:55594613 LGALS3 0.58 13.58 0.6 9.41e-34 Protein biomarker; LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13012494 chr21:47604986 C21orf56 0.47 7.18 0.37 4.52e-12 Testicular germ cell tumor; LUSC cis rs7572644 0.782 rs4666030 chr2:28097222 C/T cg27432699 chr2:27873401 GPN1 0.52 6.78 0.35 5.61e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6964587 0.692 rs2374550 chr7:91820987 A/G cg17063962 chr7:91808500 NA 0.6 10.07 0.48 5.31e-21 Breast cancer; LUSC cis rs1682361 1 rs1682361 chr3:136734014 G/C cg12473912 chr3:136751656 NA 0.45 7.91 0.4 3.75e-14 Schizophrenia; LUSC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg13628971 chr7:2884303 GNA12 0.45 6.38 0.33 6.04e-10 Height; LUSC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21582582 chr3:182698605 DCUN1D1 0.48 8.4 0.42 1.29e-15 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg13395646 chr4:1353034 KIAA1530 -0.57 -8.8 -0.43 7.61e-17 Obesity-related traits; LUSC cis rs80282103 0.571 rs10047269 chr10:1103058 G/A cg18964960 chr10:1102726 WDR37 0.72 6.52 0.34 2.57e-10 Glomerular filtration rate (creatinine); LUSC cis rs4776059 0.761 rs61731670 chr15:52901283 T/C cg22715398 chr15:52968154 KIAA1370 0.67 8.55 0.42 4.48e-16 Schizophrenia; LUSC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg11211951 chr8:145729740 GPT -0.54 -9.84 -0.47 3.23e-20 Age at first birth; LUSC cis rs6499755 0.901 rs2042447 chr16:55352022 A/C cg02859129 chr16:55357253 IRX6 -0.34 -6.0 -0.31 5.1e-9 Hypospadias; LUSC cis rs7681440 0.543 rs2619370 chr4:90736585 C/T cg06632027 chr4:90757378 SNCA -0.36 -5.65 -0.3 3.4e-8 Dementia with Lewy bodies; LUSC cis rs6964587 0.967 rs58673519 chr7:91823887 T/G cg22709100 chr7:91322751 NA 0.4 5.75 0.3 1.98e-8 Breast cancer; LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.24 0.45 2.96e-18 Bipolar disorder; LUSC trans rs1973993 0.567 rs2800431 chr1:97000998 C/T cg10631902 chr5:14652156 NA 0.47 7.74 0.39 1.16e-13 Weight; LUSC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg02018176 chr4:1364513 KIAA1530 0.56 9.81 0.47 3.81e-20 Longevity; LUSC cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs9287719 0.967 rs7600587 chr2:10739851 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs4594175 0.926 rs60234748 chr14:51630102 T/C cg23942311 chr14:51606299 NA 0.3 5.79 0.3 1.6e-8 Cancer; LUSC trans rs393155 0.517 rs330050 chr8:9087679 G/C cg08975724 chr8:8085496 FLJ10661 -0.45 -6.6 -0.34 1.65e-10 Neuroticism; LUSC cis rs2085601 0.519 rs1708679 chr4:89976963 T/C cg17769793 chr4:89976368 FAM13A -0.33 -5.68 -0.3 2.97e-8 Hair greying; LUSC cis rs1371867 0.846 rs1660349 chr8:101319326 G/A cg06636551 chr8:101224915 SPAG1 -0.45 -8.24 -0.41 4.04e-15 Atrioventricular conduction; LUSC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg24642844 chr7:1081250 C7orf50 -0.46 -7.34 -0.37 1.64e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17030434 0.728 rs16998891 chr4:154646419 T/G cg14289246 chr4:154710475 SFRP2 -0.5 -6.78 -0.35 5.5e-11 Electrocardiographic conduction measures; LUSC cis rs453301 0.522 rs2929309 chr8:9083771 C/A cg15556689 chr8:8085844 FLJ10661 -0.52 -7.77 -0.39 9.55e-14 Joint mobility (Beighton score); LUSC cis rs4319547 0.656 rs1553179 chr12:122831073 A/G cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.26 -0.41 3.44e-15 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03331490 chr10:120840461 EIF3A -0.42 -6.13 -0.32 2.46e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC trans rs8072100 0.967 rs4338849 chr17:45512483 A/G cg04995722 chr7:26192034 NFE2L3 -0.37 -6.01 -0.31 4.8e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4478858 0.735 rs6685728 chr1:31802550 T/C cg00250761 chr1:31883323 NA -0.36 -8.95 -0.44 2.49e-17 Alcohol dependence; LUSC cis rs10419226 0.511 rs2214524 chr19:18787661 C/A cg22001208 chr19:18782374 NA -0.37 -6.07 -0.32 3.54e-9 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg20887711 chr4:1340912 KIAA1530 0.46 7.16 0.36 5.1e-12 Obesity-related traits; LUSC cis rs9467160 0.734 rs10946702 chr6:24462672 A/G cg20631270 chr6:24437470 GPLD1 -0.41 -5.79 -0.3 1.66e-8 Liver enzyme levels; LUSC cis rs1348850 0.645 rs13431091 chr2:178434615 A/G cg22681709 chr2:178499509 PDE11A -0.38 -5.75 -0.3 2.05e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10752881 1.000 rs10737236 chr1:182988608 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.68 -10.51 -0.5 1.69e-22 Colorectal cancer; LUSC cis rs7091068 0.802 rs10786121 chr10:95419796 G/A cg20715218 chr10:95462985 C10orf4 0.57 6.48 0.33 3.22e-10 Urinary tract infection frequency; LUSC trans rs3942852 0.712 rs2174129 chr11:48108557 A/C cg15704280 chr7:45808275 SEPT13 -0.57 -7.16 -0.36 5.13e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs80282103 0.764 rs10047382 chr10:1102868 T/C cg23359895 chr10:1095482 IDI1 0.64 5.76 0.3 1.88e-8 Glomerular filtration rate (creatinine); LUSC cis rs7586879 0.828 rs12986610 chr2:25106265 A/G cg01884057 chr2:25150051 NA -0.41 -8.7 -0.43 1.57e-16 Body mass index; LUSC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04685880 chr19:55988027 ZNF628 -0.4 -5.97 -0.31 6.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7575217 0.961 rs733830 chr2:101778319 C/T cg23907051 chr2:101730305 TBC1D8 0.27 6.95 0.36 1.9e-11 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.61 -7.6 -0.38 3.01e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9549260 0.816 rs7334318 chr13:41217410 C/G cg21288729 chr13:41239152 FOXO1 0.66 10.17 0.49 2.4e-21 Red blood cell count; LUSC cis rs4631830 0.832 rs2611513 chr10:51515457 A/G cg16070123 chr10:51489643 NA 0.52 8.38 0.42 1.48e-15 Prostate-specific antigen levels; LUSC cis rs7927592 0.913 rs59056571 chr11:68272973 T/G cg16797656 chr11:68205561 LRP5 0.37 6.12 0.32 2.59e-9 Total body bone mineral density; LUSC cis rs4900538 0.855 rs1209151 chr14:102893756 C/T cg18135206 chr14:102964638 TECPR2 -0.99 -19.15 -0.72 1.06e-55 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2839186 0.900 rs2839200 chr21:47709095 C/T cg05896524 chr21:47604654 C21orf56 0.4 5.85 0.3 1.16e-8 Testicular germ cell tumor; LUSC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg17971929 chr21:40555470 PSMG1 -0.51 -7.63 -0.39 2.41e-13 Menarche (age at onset); LUSC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg00339695 chr16:24857497 SLC5A11 0.59 8.78 0.43 8.37e-17 Intelligence (multi-trait analysis); LUSC cis rs6696846 0.791 rs10158848 chr1:205061192 C/T cg03948781 chr1:205179583 DSTYK 0.32 6.15 0.32 2.21e-9 Red blood cell count; LUSC cis rs9462027 0.628 rs6906759 chr6:34742990 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.69 -0.3 2.74e-8 Systemic lupus erythematosus; LUSC cis rs9926296 0.609 rs4785710 chr16:89796756 C/T cg26513180 chr16:89883248 FANCA -0.55 -8.59 -0.43 3.26e-16 Vitiligo; LUSC cis rs9549367 0.789 rs6577034 chr13:113879900 T/C cg00898013 chr13:113819073 PROZ -0.57 -8.65 -0.43 2.21e-16 Platelet distribution width; LUSC cis rs2227564 0.597 rs12256103 chr10:75545251 A/G cg17411546 chr10:75410026 SYNPO2L -0.44 -5.74 -0.3 2.16e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs513349 1.000 rs513349 chr6:33541719 A/G cg24505687 chr6:33548425 BAK1 0.36 6.08 0.32 3.37e-9 Platelet count; LUSC cis rs7605827 0.930 rs12692264 chr2:15539229 T/A cg19274914 chr2:15703543 NA 0.47 9.24 0.45 3.06e-18 Educational attainment (years of education); LUSC cis rs4240897 0.835 rs4845891 chr1:12042506 T/C cg13216073 chr1:12042593 MFN2 0.38 6.76 0.35 6.29e-11 Tuberculosis; LUSC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg24250549 chr1:154909240 PMVK 0.66 11.1 0.52 1.36e-24 Prostate cancer; LUSC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 8.93 0.44 2.84e-17 Tonsillectomy; LUSC cis rs2430386 1.000 rs2430386 chr2:63178111 C/T cg17519650 chr2:63277830 OTX1 0.65 9.46 0.46 5.73e-19 Prostate cancer; LUSC cis rs3126085 0.935 rs4845429 chr1:152225376 G/C cg03465714 chr1:152285911 FLG -0.4 -5.68 -0.3 2.94e-8 Atopic dermatitis; LUSC cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg24375607 chr4:120327624 NA -0.73 -11.54 -0.53 3.67e-26 Corneal astigmatism; LUSC cis rs17125944 0.505 rs28568967 chr14:53223060 A/G cg13660082 chr14:53194042 PSMC6 -0.78 -6.81 -0.35 4.55e-11 Alzheimer's disease (late onset); LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.45 0.33 3.86e-10 Menopause (age at onset); LUSC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg13175981 chr1:150552382 MCL1 0.52 7.38 0.37 1.23e-12 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC trans rs1908814 0.516 rs7825529 chr8:11794444 C/T cg15556689 chr8:8085844 FLJ10661 0.57 8.58 0.42 3.51e-16 Neuroticism; LUSC cis rs10992471 0.603 rs10114912 chr9:95307863 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.88 -0.35 2.92e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9807989 0.839 rs9808453 chr2:102971306 C/A cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.46 7.52 0.38 5.03e-13 Parkinson's disease; LUSC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg02269571 chr22:50332266 NA 0.59 8.74 0.43 1.13e-16 Schizophrenia; LUSC cis rs11048434 0.736 rs12833375 chr12:9112018 A/T cg04155231 chr12:9217510 LOC144571 0.3 5.7 0.3 2.67e-8 Sjögren's syndrome; LUSC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.92e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9640161 0.659 rs7788316 chr7:150013995 A/T cg10018233 chr7:150070692 REPIN1 0.34 6.08 0.32 3.33e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.82 -0.35 4.21e-11 Aortic root size; LUSC cis rs9326248 0.530 rs11216171 chr11:116749113 T/A cg20608306 chr11:116969690 SIK3 0.38 6.33 0.33 8e-10 Blood protein levels; LUSC cis rs9467160 0.651 rs9393557 chr6:24453195 C/G cg20631270 chr6:24437470 GPLD1 0.41 6.34 0.33 7.38e-10 Liver enzyme levels; LUSC cis rs7937682 0.924 rs495460 chr11:111504777 G/A cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg04315214 chr1:2043799 PRKCZ -0.4 -8.02 -0.4 1.74e-14 Height; LUSC cis rs4478858 0.647 rs11577679 chr1:31726185 T/C cg00250761 chr1:31883323 NA -0.34 -8.21 -0.41 4.89e-15 Alcohol dependence; LUSC trans rs11992162 0.636 rs4841645 chr8:11798684 G/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.43 -0.33 4.41e-10 Monocyte count; LUSC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg18512352 chr11:47633146 NA -0.47 -9.58 -0.46 2.37e-19 Subjective well-being; LUSC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg16414030 chr3:133502952 NA -0.42 -6.52 -0.34 2.66e-10 Iron status biomarkers; LUSC cis rs4268898 0.662 rs72793213 chr2:24524725 A/G cg06627628 chr2:24431161 ITSN2 -0.86 -12.9 -0.58 3.55e-31 Asthma; LUSC cis rs9323205 0.798 rs2999392 chr14:51655145 A/G cg23942311 chr14:51606299 NA -0.39 -8.04 -0.4 1.57e-14 Cancer; LUSC cis rs10986311 0.722 rs944339 chr9:127040978 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.4 -6.58 -0.34 1.87e-10 Vitiligo; LUSC cis rs6961069 0.585 rs12667404 chr7:80251463 C/T cg04458919 chr7:80252533 CD36 -0.39 -6.87 -0.35 3.23e-11 Platelet count; LUSC cis rs7572644 0.640 rs13027666 chr2:28058433 T/C cg27432699 chr2:27873401 GPN1 0.51 6.83 0.35 3.92e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7914558 0.966 rs3977751 chr10:104920232 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.75 -0.35 6.62e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs637571 0.512 rs660118 chr11:65735174 G/C cg17712092 chr4:129076599 LARP1B 0.82 12.34 0.56 4.47e-29 Eosinophil percentage of white cells; LUSC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg15147215 chr3:52552868 STAB1 -0.3 -6.0 -0.31 5.01e-9 Electroencephalogram traits; LUSC cis rs78707713 0.535 rs3812705 chr10:71211146 A/G cg14388049 chr10:71211838 TSPAN15 -0.33 -5.99 -0.31 5.28e-9 Venous thromboembolism; LUSC cis rs10203711 1.000 rs4663941 chr2:239574279 A/G cg14580085 chr2:239553406 NA 0.39 6.53 0.34 2.42e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg20933634 chr6:27740509 NA 0.45 6.03 0.31 4.4e-9 Parkinson's disease; LUSC cis rs4595586 0.545 rs3914596 chr12:39388538 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg17971929 chr21:40555470 PSMG1 -0.53 -7.94 -0.4 3.06e-14 Menarche (age at onset); LUSC cis rs4654899 0.865 rs61779075 chr1:21417027 T/C cg01072550 chr1:21505969 NA -0.52 -7.6 -0.38 2.99e-13 Superior frontal gyrus grey matter volume; LUSC cis rs11676348 0.935 rs2230054 chr2:219000310 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.37 -5.69 -0.3 2.77e-8 Ulcerative colitis; LUSC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg04317338 chr11:64019027 PLCB3 0.6 6.32 0.33 8.27e-10 Mean platelet volume; LUSC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg24838063 chr12:130822603 PIWIL1 0.7 10.75 0.51 2.38e-23 Menopause (age at onset); LUSC cis rs10779751 1.000 rs12124983 chr1:11286178 C/T cg08854313 chr1:11322531 MTOR -0.89 -15.36 -0.64 1.17e-40 Body mass index; LUSC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg05340658 chr4:99064831 C4orf37 0.63 10.64 0.5 5.67e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.65 10.8 0.51 1.65e-23 Lymphocyte counts; LUSC cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -1.14 -25.13 -0.81 5.48e-79 Chronic sinus infection; LUSC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.6 -0.38 3.03e-13 Developmental language disorder (linguistic errors); LUSC cis rs748404 0.587 rs9920879 chr15:43639770 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.41 0.33 4.97e-10 Lung cancer; LUSC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg18230493 chr5:56204884 C5orf35 -0.95 -13.98 -0.61 2.77e-35 Initial pursuit acceleration; LUSC cis rs6701037 1.000 rs34493921 chr1:175122759 A/G cg17845761 chr1:175162550 KIAA0040 -0.34 -6.57 -0.34 1.98e-10 Alcohol dependence; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg16405210 chr4:1374714 KIAA1530 -0.55 -8.72 -0.43 1.34e-16 Obesity-related traits; LUSC cis rs637571 0.510 rs4930320 chr11:65576788 C/G cg10604040 chr11:65559109 OVOL1 0.31 5.78 0.3 1.72e-8 Eosinophil percentage of white cells; LUSC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg06453172 chr10:134556979 INPP5A -0.49 -6.11 -0.32 2.78e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs11622475 1.000 rs1187446 chr14:104409896 C/T cg12183467 chr14:104352244 NA -0.43 -7.73 -0.39 1.27e-13 Bipolar disorder; LUSC cis rs9420 0.961 rs71484468 chr11:57632799 G/C cg23127183 chr11:57508653 C11orf31 -0.56 -8.36 -0.42 1.71e-15 Schizophrenia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14672709 chr17:48133110 ITGA3 0.39 6.12 0.32 2.58e-9 Asthma; LUSC cis rs2011503 1.000 rs1036215 chr19:19657198 C/T cg10172584 chr19:19639581 YJEFN3 -0.51 -5.85 -0.3 1.18e-8 Bipolar disorder; LUSC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.02 -0.31 4.61e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2e-12 Bipolar disorder; LUSC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg22535103 chr8:58192502 C8orf71 -0.84 -10.25 -0.49 1.25e-21 Developmental language disorder (linguistic errors); LUSC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg11812906 chr14:75593930 NEK9 -0.62 -10.07 -0.48 5.2e-21 Height; LUSC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg18230493 chr5:56204884 C5orf35 -0.89 -13.7 -0.6 3.17e-34 Initial pursuit acceleration; LUSC cis rs17125944 0.615 rs7146179 chr14:53298853 A/G cg00686598 chr14:53173677 PSMC6 -0.73 -6.61 -0.34 1.52e-10 Alzheimer's disease (late onset); LUSC cis rs6696846 0.777 rs2369526 chr1:205054406 C/T cg21545522 chr1:205238299 TMCC2 0.42 8.05 0.4 1.52e-14 Red blood cell count; LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.87 0.31 1.05e-8 Menopause (age at onset); LUSC cis rs1801251 1.000 rs1801251 chr2:233633460 G/A cg08000102 chr2:233561755 GIGYF2 0.7 11.59 0.54 2.41e-26 Coronary artery disease; LUSC cis rs7588746 0.521 rs73054585 chr2:201144386 T/A cg23649088 chr2:200775458 C2orf69 -0.54 -7.22 -0.37 3.46e-12 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg01879757 chr17:41196368 BRCA1 0.43 6.55 0.34 2.23e-10 Menopause (age at onset); LUSC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.9 -0.31 8.7e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs877282 0.735 rs111609055 chr10:826539 A/G cg22713356 chr15:30763199 NA 0.76 9.94 0.48 1.43e-20 Uric acid levels; LUSC cis rs3806843 1.000 rs10223116 chr5:140192643 C/T cg19875535 chr5:140030758 IK 0.48 7.62 0.38 2.71e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs17345786 0.906 rs72946021 chr3:101250008 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 7.75 0.39 1.09e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg15605315 chr1:45957053 TESK2 0.46 7.21 0.37 3.78e-12 High light scatter reticulocyte count; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg02980000 chr4:1222292 CTBP1 -0.37 -5.67 -0.3 3.09e-8 Obesity-related traits; LUSC cis rs4363385 0.703 rs4845517 chr1:153003893 T/A cg00922841 chr1:152955080 SPRR1A -0.4 -7.08 -0.36 8.6e-12 Inflammatory skin disease; LUSC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg10523679 chr1:76189770 ACADM 0.9 16.19 0.66 6.09e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11229555 0.645 rs11229430 chr11:58181104 G/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs983392 0.709 rs2015475 chr11:59998963 A/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.93 -0.31 7.71e-9 Alzheimer's disease (late onset); LUSC cis rs12286929 0.617 rs12800807 chr11:115101353 T/C cg04055981 chr11:115044050 NA 0.35 6.23 0.32 1.41e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg15145296 chr3:125709740 NA -0.59 -6.56 -0.34 2.02e-10 Blood pressure (smoking interaction); LUSC cis rs11167764 1.000 rs3761757 chr5:141488219 A/C cg23435118 chr5:141488016 NDFIP1 -0.53 -7.43 -0.38 8.98e-13 Crohn's disease; LUSC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs250677 1.000 rs28173 chr5:148423573 C/T cg23229984 chr5:148520753 ABLIM3 0.37 6.12 0.32 2.63e-9 Breast cancer; LUSC cis rs1801251 0.778 rs2250665 chr2:233752639 A/T cg25237894 chr2:233734115 C2orf82 -0.37 -6.89 -0.35 2.86e-11 Coronary artery disease; LUSC cis rs9297145 0.761 rs62473005 chr7:98742510 G/C cg05967295 chr7:98741636 SMURF1 0.99 14.77 0.63 2.38e-38 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg25272121 chr1:152190972 HRNR -0.39 -6.75 -0.35 6.57e-11 Inflammatory skin disease; LUSC cis rs61931739 0.534 rs12831685 chr12:34038392 C/T cg06521331 chr12:34319734 NA -0.51 -8.41 -0.42 1.18e-15 Morning vs. evening chronotype; LUSC cis rs11098499 0.863 rs11098532 chr4:120490726 C/A cg24375607 chr4:120327624 NA 0.76 11.48 0.53 6.02e-26 Corneal astigmatism; LUSC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg15556689 chr8:8085844 FLJ10661 0.67 10.71 0.51 3.43e-23 Mood instability; LUSC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg20203395 chr5:56204925 C5orf35 -0.46 -6.86 -0.35 3.41e-11 Coronary artery disease; LUSC trans rs853679 0.546 rs200981 chr6:27833174 A/G cg06606381 chr12:133084897 FBRSL1 -0.75 -7.52 -0.38 5.19e-13 Depression; LUSC cis rs939658 0.805 rs1915726 chr15:79420620 C/G cg17916960 chr15:79447300 NA -0.53 -10.38 -0.49 4.61e-22 Refractive error; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14530560 chr19:41903684 BCKDHA;EXOSC5 -0.41 -5.95 -0.31 6.91e-9 Electrocardiographic conduction measures; LUSC cis rs11676348 0.967 rs4674258 chr2:218990586 C/T cg00012203 chr2:219082015 ARPC2 -0.54 -8.41 -0.42 1.2e-15 Ulcerative colitis; LUSC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg00310523 chr12:86230176 RASSF9 0.46 8.35 0.42 1.86e-15 Major depressive disorder; LUSC cis rs7584330 0.554 rs77648388 chr2:238431832 G/C cg14458575 chr2:238380390 NA 0.6 7.14 0.36 5.72e-12 Prostate cancer; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.77 0.35 5.72e-11 Obesity-related traits; LUSC cis rs6430585 0.591 rs61187091 chr2:136468238 G/A cg07169764 chr2:136633963 MCM6 1.08 14.33 0.62 1.21e-36 Corneal structure; LUSC cis rs713477 0.505 rs9635232 chr14:55887880 T/C cg13175173 chr14:55914753 NA -0.31 -5.96 -0.31 6.5e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg11752832 chr7:134001865 SLC35B4 0.59 9.31 0.45 1.76e-18 Mean platelet volume; LUSC cis rs208520 0.507 rs7755710 chr6:66783355 G/A cg07460842 chr6:66804631 NA -1.26 -27.67 -0.83 2e-88 Exhaled nitric oxide output; LUSC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg13114125 chr14:105738426 BRF1 -0.9 -15.57 -0.65 1.81e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs1376303 0.643 rs4723222 chr7:32957661 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.64 -5.67 -0.3 3.02e-8 Intelligence (multi-trait analysis); LUSC cis rs977987 0.771 rs8048527 chr16:75422054 C/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.12 -0.36 6.65e-12 Dupuytren's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11353368 chr19:47363757 NA -0.41 -6.06 -0.31 3.6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1395 1.000 rs1275530 chr2:27432547 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.39 -6.41 -0.33 4.89e-10 Blood metabolite levels; LUSC cis rs6121246 0.567 rs2811 chr20:30194248 A/G cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg21643547 chr1:205240462 TMCC2 -0.52 -10.21 -0.49 1.77e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg01324343 chr3:183735012 ABCC5 0.76 20.5 0.75 4.67e-61 Anterior chamber depth; LUSC cis rs6500602 0.727 rs4786516 chr16:4578641 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.58 0.38 3.37e-13 Schizophrenia; LUSC cis rs7481584 0.624 rs449466 chr11:3047603 C/T cg05729581 chr11:3078854 CARS 0.4 5.85 0.3 1.16e-8 Calcium levels; LUSC cis rs7100689 0.646 rs9804236 chr10:82135100 T/C cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg05025164 chr4:1340916 KIAA1530 -0.5 -7.63 -0.39 2.42e-13 Obesity-related traits; LUSC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg03517284 chr6:25882590 NA -0.42 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21659725 chr3:3221576 CRBN 0.89 18.56 0.71 2.38e-53 Intelligence (multi-trait analysis); LUSC cis rs6733011 0.578 rs10172158 chr2:99509605 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.07 -0.36 9.02e-12 Bipolar disorder; LUSC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg17971929 chr21:40555470 PSMG1 0.79 13.82 0.6 1.1e-34 Cognitive function; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2840044 1.000 rs225251 chr17:33951228 A/C cg19694781 chr19:47549865 TMEM160 -0.6 -9.68 -0.47 1.11e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.82 12.36 0.56 3.88e-29 Cognitive test performance; LUSC cis rs1729951 0.575 rs747843 chr3:136703130 G/C cg21827317 chr3:136751795 NA 0.39 7.17 0.37 4.88e-12 Neuroticism; LUSC cis rs941408 1.000 rs1640271 chr19:2799979 C/T cg00079169 chr19:2811669 THOP1 0.35 5.83 0.3 1.31e-8 Total cholesterol levels; LUSC cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.37 0.49 4.87e-22 Schizophrenia; LUSC cis rs9611565 0.729 rs137831 chr22:41903813 A/C cg03806693 chr22:41940476 POLR3H -0.83 -11.92 -0.55 1.59e-27 Vitiligo; LUSC cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg04990556 chr1:26633338 UBXN11 -0.45 -5.94 -0.31 7.02e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs2625529 0.652 rs2415128 chr15:72191073 T/C cg16672083 chr15:72433130 SENP8 0.48 7.81 0.39 7.5e-14 Red blood cell count; LUSC cis rs10740039 0.804 rs7093882 chr10:62394621 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27093425 chr17:79191690 AZI1 0.4 6.05 0.31 3.82e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4843747 0.605 rs4072779 chr16:88107290 C/T cg26811252 chr16:29126840 RRN3P2 0.58 9.33 0.45 1.5e-18 Menopause (age at onset); LUSC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg21573476 chr21:45109991 RRP1B -0.39 -6.23 -0.32 1.4e-9 Mean corpuscular volume; LUSC cis rs9513627 1.000 rs7321381 chr13:100126156 G/A cg25919922 chr13:100150906 NA -0.74 -6.55 -0.34 2.24e-10 Obesity-related traits; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.34 0.77 2.97e-68 Prudent dietary pattern; LUSC trans rs11696501 0.688 rs6094192 chr20:44297796 G/A cg03272292 chr12:48577362 C12orf68 0.5 5.98 0.31 5.85e-9 Brain structure; LUSC cis rs2285947 0.967 rs2285944 chr7:21582964 A/T cg04471919 chr7:21584483 DNAH11 0.35 7.75 0.39 1.1e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg06873352 chr17:61820015 STRADA 0.67 11.85 0.54 2.86e-27 Prudent dietary pattern; LUSC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg23743428 chr13:21893420 NA -0.44 -8.84 -0.44 5.57e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs870825 0.616 rs79884757 chr4:185621454 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs11098499 1.000 rs6849889 chr4:120186348 A/C cg09307838 chr4:120376055 NA 0.67 9.63 0.47 1.62e-19 Corneal astigmatism; LUSC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg25767906 chr1:53392781 SCP2 -0.51 -9.51 -0.46 3.86e-19 Monocyte count; LUSC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg03929089 chr4:120376271 NA -1.04 -20.33 -0.74 2.31e-60 Height; LUSC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg15704280 chr7:45808275 SEPT13 -1.11 -24.16 -0.8 2.82e-75 Height; LUSC cis rs425277 1.000 rs427811 chr1:2075560 T/G cg24578937 chr1:2090814 PRKCZ 0.6 13.82 0.6 1.13e-34 Height; LUSC cis rs4363385 0.550 rs6661932 chr1:152896734 T/C cg25856811 chr1:152973957 SPRR3 -0.39 -6.21 -0.32 1.54e-9 Inflammatory skin disease; LUSC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10208940 0.841 rs10172125 chr2:68787191 T/G cg12452813 chr2:68675892 NA 0.57 5.92 0.31 7.99e-9 Urate levels in lean individuals; LUSC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg16624210 chr5:671434 TPPP 0.5 6.38 0.33 6.07e-10 Obesity-related traits; LUSC cis rs3008870 1.000 rs11208979 chr1:67442275 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.68 0.39 1.83e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg18827107 chr12:86230957 RASSF9 0.45 6.86 0.35 3.4e-11 Major depressive disorder; LUSC cis rs7246657 0.941 rs12982333 chr19:37794724 A/G cg23950597 chr19:37808831 NA -0.64 -7.47 -0.38 6.98e-13 Coronary artery calcification; LUSC cis rs16910800 1.000 rs2468648 chr11:23201494 C/G cg20040320 chr11:23191996 NA 0.42 6.34 0.33 7.27e-10 Cancer; LUSC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.19e-9 Mean platelet volume; LUSC cis rs11608355 0.521 rs9888353 chr12:109843594 G/A cg19025524 chr12:109796872 NA -0.4 -7.37 -0.37 1.39e-12 Neuroticism; LUSC cis rs2479724 0.755 rs4318867 chr6:41753670 G/T cg17623882 chr6:41773611 USP49 0.62 10.37 0.49 5.14e-22 Menarche (age at onset); LUSC cis rs72781680 1.000 rs61739076 chr2:24149439 G/A cg08917208 chr2:24149416 ATAD2B 1.01 10.61 0.5 7.29e-23 Lymphocyte counts; LUSC cis rs1577917 0.696 rs2842603 chr6:86336337 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.82 -0.39 6.85e-14 Response to antipsychotic treatment; LUSC trans rs11098499 0.954 rs6848389 chr4:120402622 A/G cg25214090 chr10:38739885 LOC399744 0.51 7.7 0.39 1.58e-13 Corneal astigmatism; LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC trans rs4332037 0.901 rs7791899 chr7:1935988 T/C cg25206134 chr2:45395956 NA 0.57 6.55 0.34 2.14e-10 Bipolar disorder; LUSC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.68 0.3 2.9e-8 Self-reported allergy; LUSC trans rs7507204 0.723 rs12982194 chr19:3411947 G/A cg08382705 chr11:45687319 CHST1 -0.52 -7.0 -0.36 1.38e-11 Height; LUSC cis rs4253772 0.720 rs4253778 chr22:46630634 C/G cg09491104 chr22:46646882 C22orf40 -0.6 -8.82 -0.43 6.55e-17 LDL cholesterol;Cholesterol, total; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg22065733 chr8:11801320 NA 0.78 6.09 0.32 3.03e-9 Cognitive performance; LUSC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg20608306 chr11:116969690 SIK3 0.39 6.66 0.34 1.12e-10 Blood protein levels; LUSC cis rs11608355 0.515 rs7136048 chr12:109903926 A/G cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs3008870 0.916 rs2025608 chr1:67422550 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.34 0.64 1.46e-40 Lymphocyte percentage of white cells; LUSC cis rs1348850 0.668 rs4893972 chr2:178496874 T/C cg22681709 chr2:178499509 PDE11A -0.46 -7.46 -0.38 7.41e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.71e-13 Bipolar disorder; LUSC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg26380479 chr7:97908229 NA -0.28 -6.25 -0.32 1.24e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1524927 0.966 rs2260 chr7:96364457 T/C cg03808172 chr7:96339361 SHFM1 0.43 6.52 0.34 2.63e-10 Total body bone mineral density; LUSC cis rs11098499 0.738 rs10026493 chr4:120384194 C/G cg24375607 chr4:120327624 NA 0.79 11.69 0.54 1.03e-26 Corneal astigmatism; LUSC cis rs2677744 0.563 rs8024249 chr15:91494249 T/C cg23684204 chr15:91497937 RCCD1 0.39 5.68 0.3 2.87e-8 Attention deficit hyperactivity disorder; LUSC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg18135555 chr8:22132992 PIWIL2 0.39 7.83 0.39 6.33e-14 Hypertriglyceridemia; LUSC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg05340658 chr4:99064831 C4orf37 0.62 10.19 0.49 2.02e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs17685 0.712 rs28456330 chr7:75810542 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.36 -0.37 1.45e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2204008 0.777 rs6582664 chr12:37947022 A/G cg13010199 chr12:38710504 ALG10B -0.6 -9.35 -0.46 1.32e-18 Bladder cancer; LUSC trans rs9784649 0.891 rs57355285 chr5:25016384 C/G cg08600765 chr20:34638493 LOC647979 -0.55 -6.36 -0.33 6.71e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6733011 0.628 rs981602 chr2:99464275 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.44 -6.2 -0.32 1.71e-9 Bipolar disorder; LUSC cis rs10876993 0.890 rs2640630 chr12:58067267 T/C cg18357645 chr12:58087776 OS9 0.54 8.3 0.41 2.58e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg24060327 chr5:131705240 SLC22A5 0.5 7.69 0.39 1.63e-13 Acylcarnitine levels; LUSC cis rs2486288 0.539 rs2433601 chr15:45716425 T/C cg21132104 chr15:45694354 SPATA5L1 0.4 5.83 0.3 1.32e-8 Glomerular filtration rate; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg17142723 chr17:41324085 NBR1 0.28 6.4 0.33 5.38e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg00745463 chr17:30367425 LRRC37B -0.7 -8.63 -0.43 2.59e-16 Hip circumference adjusted for BMI; LUSC cis rs7267979 0.714 rs3787082 chr20:25235736 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.66 12.25 0.56 9.41e-29 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2857891 0.773 rs2638100 chr11:6969676 C/G cg04053776 chr11:6947353 ZNF215 0.41 5.74 0.3 2.09e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs17253792 0.822 rs74053651 chr14:56125366 C/T cg01858014 chr14:56050164 KTN1 -0.69 -6.06 -0.31 3.61e-9 Putamen volume; LUSC cis rs1662342 1.000 rs1662344 chr18:3251992 A/G cg00760847 chr18:3262519 MYL12B -0.58 -5.68 -0.3 2.97e-8 QRS duration; LUSC cis rs17539620 0.506 rs62432749 chr6:154839219 G/A cg20019720 chr6:154832845 CNKSR3 0.63 8.78 0.43 8.57e-17 Lipoprotein (a) levels; LUSC cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg22782873 chr19:19639568 YJEFN3 0.53 6.51 0.34 2.82e-10 Bipolar disorder; LUSC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg03929089 chr4:120376271 NA 0.93 14.9 0.63 7.79e-39 Coronary artery disease; LUSC cis rs11785400 0.793 rs7017851 chr8:143722038 G/T cg10596483 chr8:143751796 JRK 0.52 7.33 0.37 1.73e-12 Schizophrenia; LUSC cis rs10843647 0.875 rs12831489 chr12:30336349 A/G cg12718339 chr12:29936407 TMTC1 0.34 5.67 0.3 3.02e-8 Glucose homeostasis traits; LUSC cis rs11264213 0.901 rs79303353 chr1:36402056 G/A cg27506609 chr1:36549197 TEKT2 0.7 8.04 0.4 1.62e-14 Schizophrenia; LUSC cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg13256891 chr4:100009986 ADH5 0.51 7.03 0.36 1.21e-11 Alcohol dependence; LUSC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg00310523 chr12:86230176 RASSF9 0.52 9.83 0.47 3.52e-20 Major depressive disorder; LUSC cis rs9921338 0.961 rs7202814 chr16:11389774 C/T cg00044050 chr16:11439710 C16orf75 -0.49 -6.79 -0.35 5.04e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2067615 0.579 rs3910854 chr12:107165669 T/C cg15890332 chr12:107067104 RFX4 0.34 6.18 0.32 1.87e-9 Heart rate; LUSC cis rs9921338 0.924 rs7193645 chr16:11381036 A/G cg00044050 chr16:11439710 C16orf75 -0.51 -6.97 -0.36 1.65e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs4906332 0.899 rs12888042 chr14:103891709 G/A cg04998671 chr14:104000505 TRMT61A -0.46 -7.18 -0.37 4.67e-12 Coronary artery disease; LUSC cis rs4666002 0.789 rs12998770 chr2:27913188 T/C cg27432699 chr2:27873401 GPN1 0.51 6.9 0.35 2.63e-11 Phospholipid levels (plasma); LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg08736216 chr1:53307985 ZYG11A -0.28 -5.82 -0.3 1.38e-8 Monocyte count; LUSC cis rs11605924 1.000 rs1401419 chr11:45879739 T/C ch.11.939596F chr11:45881766 CRY2 -0.55 -8.39 -0.42 1.38e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg08048268 chr3:133502702 NA -0.38 -6.82 -0.35 4.23e-11 Iron status biomarkers; LUSC cis rs8099014 1.000 rs4940697 chr18:56108485 G/A cg12907477 chr18:56117327 MIR122 0.44 7.07 0.36 9.09e-12 Platelet count; LUSC cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg18196295 chr10:418757 DIP2C -0.45 -6.9 -0.35 2.63e-11 Psychosis in Alzheimer's disease; LUSC cis rs2370759 0.945 rs3740237 chr10:32557592 G/C cg01819863 chr10:32635814 EPC1 1.04 10.81 0.51 1.53e-23 Sexual dysfunction (female); LUSC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11890956 chr21:40555474 PSMG1 -0.86 -14.89 -0.63 8.47e-39 Cognitive function; LUSC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs11190604 1.000 rs2489039 chr10:102328036 T/A cg16342193 chr10:102329863 NA -0.37 -6.41 -0.33 4.83e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7208859 0.623 rs8075341 chr17:29136565 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs60695258 0.594 rs6531946 chr4:87965391 T/A cg10685359 chr4:87814065 C4orf36 -0.34 -6.06 -0.31 3.59e-9 Hematocrit; LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9388451 0.874 rs3734634 chr6:126111800 G/A cg10911889 chr6:126070802 HEY2 0.42 6.46 0.33 3.7e-10 Brugada syndrome; LUSC trans rs1941687 0.800 rs17753910 chr18:31387643 T/C cg27147174 chr7:100797783 AP1S1 -0.46 -6.75 -0.35 6.53e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg01879757 chr17:41196368 BRCA1 -0.45 -6.99 -0.36 1.54e-11 Menopause (age at onset); LUSC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC trans rs1194708 0.688 rs1561662 chr10:54240712 C/T cg06772874 chr1:110090953 GNAI3 0.43 5.99 0.31 5.36e-9 Chin dimples; LUSC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg17330251 chr7:94953956 PON1 -0.36 -5.88 -0.31 9.79e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7267979 1.000 rs4815406 chr20:25341316 C/G cg03522245 chr20:25566470 NINL -0.35 -5.68 -0.3 2.89e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg02951883 chr7:2050386 MAD1L1 -0.51 -9.09 -0.45 9.24e-18 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.580 rs6121016 chr20:30245239 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.69 -0.34 9.22e-11 Mean corpuscular hemoglobin; LUSC cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg23711669 chr6:146136114 FBXO30 0.81 14.04 0.61 1.6e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs2742417 1.000 rs2673035 chr3:45753665 C/G cg09608765 chr3:45636137 LIMD1 -0.37 -7.39 -0.38 1.16e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.58 -0.57 5.63e-30 Alzheimer's disease; LUSC trans rs7647973 0.588 rs4855848 chr3:49653457 C/T cg16286249 chr1:33625400 TRIM62 0.5 6.06 0.31 3.68e-9 Menarche (age at onset); LUSC cis rs134594 1.000 rs134609 chr22:29475583 C/T cg03665785 chr22:29458676 C22orf31 0.28 5.69 0.3 2.78e-8 Birth weight; LUSC cis rs6940638 0.688 rs7744759 chr6:27119826 G/A cg12826209 chr6:26865740 GUSBL1 0.52 7.51 0.38 5.41e-13 Intelligence (multi-trait analysis); LUSC trans rs7939886 0.920 rs11231794 chr11:55765776 T/C cg03929089 chr4:120376271 NA 0.73 6.08 0.32 3.26e-9 Myopia (pathological); LUSC cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22857025 chr5:266934 NA -1.18 -14.3 -0.62 1.62e-36 Breast cancer; LUSC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg04455712 chr21:45112962 RRP1B 0.44 7.91 0.4 3.9e-14 Mean corpuscular volume; LUSC cis rs865483 0.895 rs853211 chr17:35828164 T/C cg06716730 chr17:35851459 DUSP14 0.28 6.18 0.32 1.91e-9 Monocyte count; LUSC cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg26695010 chr11:65641043 EFEMP2 0.44 6.44 0.33 4.21e-10 Eosinophil percentage of white cells; LUSC cis rs7481584 0.624 rs397919 chr11:3063094 A/C cg25174290 chr11:3078921 CARS -0.42 -6.21 -0.32 1.58e-9 Calcium levels; LUSC cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg24642439 chr20:33292090 TP53INP2 -0.5 -7.48 -0.38 6.41e-13 Glomerular filtration rate (creatinine); LUSC cis rs8017423 0.935 rs11628952 chr14:90734953 T/C cg14092571 chr14:90743983 NA 0.36 5.78 0.3 1.69e-8 Mortality in heart failure; LUSC cis rs9560113 1.000 rs4773383 chr13:112177764 C/T cg14154082 chr13:112174009 NA 0.38 7.76 0.39 1.03e-13 Menarche (age at onset); LUSC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.99 0.4 2.22e-14 Bipolar disorder; LUSC trans rs6598955 0.671 rs17257176 chr1:26578233 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg11057378 chr10:81107060 PPIF 0.39 6.15 0.32 2.23e-9 Height; LUSC cis rs950169 0.840 rs72748702 chr15:84915246 A/G cg17507749 chr15:85114479 UBE2QP1 0.68 8.74 0.43 1.18e-16 Schizophrenia; LUSC cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.69 -7.62 -0.38 2.68e-13 Lung cancer in ever smokers; LUSC trans rs2243480 0.803 rs55700941 chr7:65389800 T/A cg10756647 chr7:56101905 PSPH 0.89 8.62 0.43 2.81e-16 Diabetic kidney disease; LUSC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs72772090 0.539 rs11738810 chr5:96119055 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.58 -0.34 1.83e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9467773 0.967 rs6924865 chr6:26521353 A/G cg09904177 chr6:26538194 HMGN4 0.75 14.21 0.61 3.52e-36 Intelligence (multi-trait analysis); LUSC cis rs477692 1.000 rs506274 chr10:131409392 T/A cg05714579 chr10:131428358 MGMT 0.53 7.84 0.39 6.06e-14 Response to temozolomide; LUSC cis rs1775715 0.737 rs11008695 chr10:32216887 T/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.55 0.34 2.2e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2075165 0.901 rs10908492 chr1:156224795 C/T cg20302342 chr1:156215951 PAQR6 0.33 6.41 0.33 5.09e-10 Tonsillectomy; LUSC cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg24642439 chr20:33292090 TP53INP2 -0.48 -7.39 -0.37 1.2e-12 Glomerular filtration rate (creatinine); LUSC cis rs9325144 0.624 rs10506126 chr12:39123244 G/A cg26384229 chr12:38710491 ALG10B -0.59 -9.13 -0.45 6.6e-18 Morning vs. evening chronotype; LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg08470875 chr2:26401718 FAM59B 0.78 9.23 0.45 3.1e-18 Gut microbiome composition (summer); LUSC trans rs747782 0.527 rs76142260 chr11:48331068 T/C cg03929089 chr4:120376271 NA 0.7 5.94 0.31 7.05e-9 Intraocular pressure; LUSC cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg08999081 chr20:33150536 PIGU 0.44 8.04 0.4 1.57e-14 Coronary artery disease; LUSC trans rs9929218 1.000 rs13333528 chr16:68790502 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -11.97 -0.55 9.98e-28 Colorectal cancer; LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.24 0.32 1.33e-9 Menopause (age at onset); LUSC cis rs7824557 0.592 rs2572371 chr8:11223793 G/T cg27411982 chr8:10470053 RP1L1 0.37 5.84 0.3 1.27e-8 Retinal vascular caliber; LUSC cis rs2262909 0.962 rs56369285 chr19:22267185 T/C cg11619707 chr19:22235551 ZNF257 0.39 5.83 0.3 1.29e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs983392 0.805 rs11230183 chr11:59965725 C/T cg20284999 chr11:59952153 MS4A6A -0.38 -6.2 -0.32 1.66e-9 Alzheimer's disease (late onset); LUSC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg18876405 chr7:65276391 NA -0.55 -8.61 -0.43 2.96e-16 Aortic root size; LUSC trans rs57502260 0.704 rs41478448 chr11:68181621 A/G cg00664054 chr8:21998309 REEP4 0.39 6.08 0.32 3.29e-9 Total body bone mineral density (age 45-60); LUSC cis rs6840360 1.000 rs6840678 chr4:152604331 C/G cg22705602 chr4:152727874 NA 0.3 6.45 0.33 3.91e-10 Intelligence (multi-trait analysis); LUSC cis rs73058052 1.000 rs3760707 chr19:50084454 T/C cg09250473 chr19:50168907 IRF3;BCL2L12 0.5 5.78 0.3 1.72e-8 Fibrinogen levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12573119 chr4:78977690 FRAS1 0.45 6.68 0.34 1.02e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg20476274 chr7:133979776 SLC35B4 0.87 16.7 0.67 6.08e-46 Mean platelet volume; LUSC cis rs765787 0.530 rs11070451 chr15:45533541 T/C cg25801113 chr15:45476975 SHF 0.35 7.17 0.37 4.84e-12 Uric acid levels; LUSC cis rs1775715 0.870 rs1755084 chr10:32253709 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.41 0.33 4.83e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.9 0.31 8.87e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg03354898 chr7:1950403 MAD1L1 -0.41 -8.36 -0.42 1.69e-15 Bipolar disorder and schizophrenia; LUSC cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg08807101 chr21:30365312 RNF160 -0.55 -8.17 -0.41 6.6e-15 Dental caries; LUSC trans rs7824557 0.527 rs2572369 chr8:11238597 C/T cg15556689 chr8:8085844 FLJ10661 -0.48 -7.21 -0.37 3.82e-12 Retinal vascular caliber; LUSC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg02423579 chr7:2872169 GNA12 -0.38 -5.99 -0.31 5.55e-9 Height; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg26755928 chr19:10363173 MRPL4 0.47 6.23 0.32 1.43e-9 Cognitive function;Information processing speed; LUSC cis rs6541297 1.000 rs6686054 chr1:230282853 C/T cg20703242 chr1:230279135 GALNT2 0.54 8.43 0.42 1.05e-15 Coronary artery disease; LUSC trans rs6089829 0.962 rs6089824 chr20:61659207 A/G cg15934090 chr1:100435551 SLC35A3 0.47 7.72 0.39 1.4e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg21285383 chr16:89894308 SPIRE2 -0.32 -6.71 -0.34 8.18e-11 Vitiligo; LUSC trans rs877282 0.842 rs7092986 chr10:756373 G/A cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg23711669 chr6:146136114 FBXO30 0.73 11.58 0.54 2.69e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs740160 0.558 rs12538893 chr7:98908497 G/A cg24650262 chr7:98904301 NA 0.63 6.74 0.35 6.87e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg24675658 chr1:53192096 ZYG11B -0.62 -9.74 -0.47 7e-20 Monocyte count; LUSC cis rs9811920 0.809 rs793443 chr3:99573547 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -7.02 -0.36 1.26e-11 Axial length; LUSC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg24838063 chr12:130822603 PIWIL1 0.69 10.79 0.51 1.69e-23 Menopause (age at onset); LUSC cis rs12220238 1.000 rs12358614 chr10:75906173 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.96 0.36 1.79e-11 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs11722228 0.522 rs73212817 chr4:10064011 T/C cg26043149 chr18:55253948 FECH 0.93 14.07 0.61 1.29e-35 Gout;Urate levels;Serum uric acid levels; LUSC cis rs7804356 1.000 rs3801816 chr7:26881177 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.58e-9 Type 1 diabetes; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.49 8.58 0.42 3.71e-16 Bipolar disorder; LUSC cis rs9807989 0.507 rs10439410 chr2:102990788 A/C cg03938978 chr2:103052716 IL18RAP -0.36 -6.85 -0.35 3.67e-11 Asthma; LUSC trans rs80346118 0.925 rs2869677 chr20:47473948 G/C cg16950247 chr11:62911616 SLC22A24 0.5 6.05 0.31 3.87e-9 Diastolic blood pressure; LUSC cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg00049323 chr5:472564 LOC25845 -0.43 -6.7 -0.34 9.09e-11 Cystic fibrosis severity; LUSC cis rs4481887 0.676 rs946761 chr1:248521032 T/C cg26353448 chr1:248524236 OR2T4 -0.33 -6.17 -0.32 1.97e-9 Common traits (Other); LUSC cis rs11690935 0.550 rs62183785 chr2:172866976 G/A cg13550731 chr2:172543902 DYNC1I2 0.53 7.96 0.4 2.7e-14 Schizophrenia; LUSC cis rs611744 0.503 rs13282220 chr8:109263043 T/C cg21045802 chr8:109455806 TTC35 0.42 6.0 0.31 5.02e-9 Dupuytren's disease; LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg18099408 chr3:52552593 STAB1 -0.43 -7.33 -0.37 1.79e-12 Bipolar disorder; LUSC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg18230493 chr5:56204884 C5orf35 -0.74 -11.76 -0.54 5.87e-27 Coronary artery disease; LUSC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -6.69 -0.34 9.68e-11 Major depressive disorder; LUSC trans rs1982346 1.000 rs2553470 chr4:106713673 G/A cg01484487 chr2:74726892 LBX2 0.52 6.12 0.32 2.55e-9 Lung function (FEV1); LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg01842473 chr11:617407 IRF7;MUPCDH -0.7 -10.13 -0.48 3.24e-21 Systemic lupus erythematosus; LUSC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.76 -0.3 1.87e-8 Depression; LUSC cis rs2637266 1.000 rs2130795 chr10:78333892 C/G cg18941641 chr10:78392320 NA 0.38 6.9 0.35 2.66e-11 Pulmonary function; LUSC trans rs7939886 0.844 rs7106504 chr11:55932827 C/T cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC trans rs7980799 0.682 rs4931719 chr12:33602986 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.94 -0.44 2.73e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs9287719 0.967 rs6744599 chr2:10747013 C/G cg03983476 chr2:10830698 NOL10 0.37 5.77 0.3 1.81e-8 Prostate cancer; LUSC cis rs6456156 0.565 rs12525345 chr6:167478875 T/C cg25258033 chr6:167368657 RNASET2 0.38 5.9 0.31 9.03e-9 Primary biliary cholangitis; LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg07507251 chr3:52567010 NT5DC2 0.33 6.27 0.32 1.12e-9 Bipolar disorder; LUSC cis rs79387448 0.638 rs6759588 chr2:103040159 A/G cg09003973 chr2:102972529 NA 1.06 10.98 0.52 3.59e-24 Gut microbiota (bacterial taxa); LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.13 0.77 1.9e-67 Prudent dietary pattern; LUSC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg06634786 chr22:41940651 POLR3H -0.48 -6.01 -0.31 4.8e-9 Vitiligo; LUSC cis rs3020736 0.500 rs6002597 chr22:42488160 C/A cg04733989 chr22:42467013 NAGA -0.62 -9.65 -0.47 1.39e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg27446573 chr6:127587934 RNF146 -0.64 -9.84 -0.47 3.09e-20 Breast cancer; LUSC cis rs660498 0.507 rs2020155 chr10:27740194 C/T cg25705717 chr10:27608719 NA 0.39 5.65 0.3 3.42e-8 Asthma (childhood onset); LUSC cis rs2274273 0.840 rs7159144 chr14:55821324 G/A cg04306507 chr14:55594613 LGALS3 0.56 13.0 0.58 1.48e-31 Protein biomarker; LUSC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -12.02 -0.55 6.45e-28 Hemoglobin concentration; LUSC cis rs62458065 1.000 rs1450868 chr7:32463666 G/A cg20159608 chr7:32802032 NA -0.57 -6.94 -0.35 2.07e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7927592 0.956 rs7116899 chr11:68385535 G/T cg20283391 chr11:68216788 NA -0.57 -8.11 -0.41 9.78e-15 Total body bone mineral density; LUSC cis rs2346177 0.844 rs34791442 chr2:46655169 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.6 -0.38 3e-13 HDL cholesterol; LUSC cis rs6665290 0.904 rs6684821 chr1:227190233 G/A cg10327440 chr1:227177885 CDC42BPA -1.22 -40.05 -0.91 1.39e-129 Myeloid white cell count; LUSC cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg16339924 chr4:17578868 LAP3 0.55 8.51 0.42 5.79e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg06618935 chr21:46677482 NA -0.39 -7.92 -0.4 3.47e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1493916 0.870 rs8083723 chr18:31384398 C/T cg13755796 chr4:20253514 NA -0.42 -6.52 -0.34 2.57e-10 Life satisfaction; LUSC cis rs722599 0.683 rs7160852 chr14:75239424 T/C cg08847533 chr14:75593920 NEK9 0.46 6.44 0.33 4.12e-10 IgG glycosylation; LUSC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg13531842 chr10:38383804 ZNF37A -0.45 -6.91 -0.35 2.53e-11 Extrinsic epigenetic age acceleration; LUSC trans rs7647973 0.593 rs9870755 chr3:49809841 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -6.44 -0.33 4.23e-10 Menarche (age at onset); LUSC cis rs6577655 0.517 rs4909294 chr8:135588020 C/T cg17885191 chr8:135476712 NA 0.6 7.92 0.4 3.49e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs1160297 0.576 rs724859 chr2:53099305 C/T cg07782112 chr2:53107842 NA 0.43 7.05 0.36 1.03e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg24503407 chr1:205819492 PM20D1 0.9 16.99 0.68 4.27e-47 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16705446 chr19:3751546 APBA3 0.47 6.75 0.35 6.54e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1801251 1.000 rs2675974 chr2:233727071 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.47 0.33 3.4e-10 Coronary artery disease; LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.64 0.39 2.31e-13 Bipolar disorder; LUSC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11890956 chr21:40555474 PSMG1 -0.9 -15.94 -0.66 5.97e-43 Cognitive function; LUSC cis rs4363385 0.818 rs377768 chr1:153016594 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.89 -0.4 4.44e-14 Inflammatory skin disease; LUSC cis rs9467773 0.967 rs9467775 chr6:26513435 G/A cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.12e-18 Intelligence (multi-trait analysis); LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg06600287 chr1:53387719 ECHDC2 -0.31 -6.41 -0.33 5.05e-10 Monocyte count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04440769 chr16:4743732 NUDT16L1 0.81 6.98 0.36 1.55e-11 Cognitive performance; LUSC cis rs11098499 0.738 rs72918577 chr4:120326701 G/A cg09307838 chr4:120376055 NA 0.78 11.3 0.53 2.75e-25 Corneal astigmatism; LUSC cis rs17102423 0.723 rs55658675 chr14:65554638 C/T cg11161011 chr14:65562177 MAX -0.81 -12.51 -0.56 1.01e-29 Obesity-related traits; LUSC cis rs35079168 0.735 rs3118540 chr9:137307106 C/T cg24164254 chr9:137329341 RXRA -0.36 -5.87 -0.31 1.03e-8 Intelligence; LUSC cis rs9420 0.961 rs1647405 chr11:57477889 C/T cg02958346 chr11:57425731 CLP1 -0.41 -6.04 -0.31 4.19e-9 Schizophrenia; LUSC cis rs4751006 0.543 rs880761 chr10:128783906 C/T cg05702161 chr10:128779687 DOCK1 -0.66 -6.1 -0.32 2.94e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs3768617 0.811 rs10911205 chr1:183009277 C/A ch.1.3577855R chr1:183094577 LAMC1 0.6 8.54 0.42 4.75e-16 Fuchs's corneal dystrophy; LUSC cis rs35264875 0.898 rs56140802 chr11:68861631 G/A cg02660097 chr11:68866761 NA 0.43 6.14 0.32 2.36e-9 Blond vs. brown hair color; LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs1609391 0.543 rs2117009 chr3:136633571 A/T cg15507776 chr3:136538369 TMEM22 -0.48 -7.81 -0.39 7.37e-14 Neuroticism; LUSC cis rs2235649 0.833 rs9927047 chr16:1851927 A/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -5.96 -0.31 6.47e-9 Blood metabolite levels; LUSC cis rs2997447 0.846 rs3008231 chr1:26402023 A/G cg19633962 chr1:26362018 EXTL1 -0.47 -5.68 -0.3 2.88e-8 QRS complex (12-leadsum); LUSC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg17848003 chr1:3704513 LRRC47 0.33 6.03 0.31 4.45e-9 Red cell distribution width; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg16393715 chr7:1948819 MAD1L1 -0.33 -5.89 -0.31 9.17e-9 Bipolar disorder and schizophrenia; LUSC cis rs7000551 0.581 rs11136030 chr8:22254235 C/T cg12081754 chr8:22256438 SLC39A14 0.98 16.04 0.66 2.49e-43 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6665290 0.935 rs17600627 chr1:227201449 A/G cg10327440 chr1:227177885 CDC42BPA -1.2 -35.46 -0.89 2.94e-115 Myeloid white cell count; LUSC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg09655341 chr17:79618100 PDE6G -0.28 -6.36 -0.33 6.81e-10 Eye color traits; LUSC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg18512352 chr11:47633146 NA -0.47 -9.36 -0.46 1.19e-18 Subjective well-being; LUSC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg08219700 chr8:58056026 NA 0.65 7.64 0.39 2.29e-13 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 6.16 0.32 2.14e-9 Tonsillectomy; LUSC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.85 -0.63 1.22e-38 Total body bone mineral density; LUSC cis rs68170813 0.559 rs77829121 chr7:106968470 A/G cg02696742 chr7:106810147 HBP1 -0.64 -9.47 -0.46 5.48e-19 Coronary artery disease; LUSC trans rs6582630 0.502 rs11181214 chr12:38298313 C/A cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.45 6.03 0.31 4.41e-9 Multiple sclerosis; LUSC cis rs9814567 0.752 rs4306899 chr3:134334513 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.78 12.57 0.57 6.33e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg21573476 chr21:45109991 RRP1B 0.41 6.71 0.34 8.44e-11 Mean corpuscular volume; LUSC cis rs2230307 0.536 rs522696 chr1:100476662 G/A cg24955406 chr1:100503596 HIAT1 0.56 6.04 0.31 4.01e-9 Carotid intima media thickness; LUSC trans rs2204008 0.536 rs12368354 chr12:38042798 G/A cg06521331 chr12:34319734 NA -0.39 -5.95 -0.31 6.77e-9 Bladder cancer; LUSC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.11e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1538970 0.924 rs4660858 chr1:45936351 G/A cg05343316 chr1:45956843 TESK2 0.69 9.61 0.47 1.78e-19 Platelet count; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg11905131 chr22:24372483 LOC391322 0.58 9.68 0.47 1.08e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4974559 0.790 rs28712208 chr4:1316695 A/T cg02980000 chr4:1222292 CTBP1 0.81 8.79 0.43 7.94e-17 Systolic blood pressure; LUSC cis rs9494145 0.648 rs7758845 chr6:135428537 A/C cg22676075 chr6:135203613 NA 0.56 8.07 0.4 1.25e-14 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs61931739 0.500 rs12809868 chr12:34464905 C/T cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.3e-10 Morning vs. evening chronotype; LUSC cis rs908922 0.676 rs12132469 chr1:152491856 G/T cg20991723 chr1:152506922 NA 0.54 10.25 0.49 1.33e-21 Hair morphology; LUSC trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs709400 0.930 rs61996717 chr14:104048571 T/C cg24130564 chr14:104152367 KLC1 -0.5 -7.15 -0.36 5.48e-12 Body mass index; LUSC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg02423579 chr7:2872169 GNA12 -0.46 -6.58 -0.34 1.81e-10 Height; LUSC cis rs1507153 0.549 rs236861 chr6:79334147 C/T cg05283184 chr6:79620031 NA 0.39 7.09 0.36 7.83e-12 Sjögren's syndrome; LUSC trans rs11098499 0.722 rs28713555 chr4:120251995 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs478304 0.514 rs75601653 chr11:65483370 C/G cg27068330 chr11:65405492 SIPA1 -0.77 -10.68 -0.5 4.39e-23 Acne (severe); LUSC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg00339695 chr16:24857497 SLC5A11 0.57 8.72 0.43 1.33e-16 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4845570 0.834 rs7007 chr1:151735576 T/C cg07092448 chr1:151763213 TDRKH -1.12 -11.56 -0.53 3.13e-26 Coronary artery disease; LUSC cis rs11785400 1.000 rs4557682 chr8:143738182 T/C cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg23303369 chr20:44641161 MMP9 0.37 6.45 0.33 3.94e-10 Intelligence (multi-trait analysis); LUSC trans rs2736345 0.535 rs4366049 chr8:11398504 A/G cg15556689 chr8:8085844 FLJ10661 0.43 6.24 0.32 1.29e-9 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg19748678 chr4:122722346 EXOSC9 0.5 7.81 0.39 7.55e-14 Type 2 diabetes; LUSC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg27432699 chr2:27873401 GPN1 -0.56 -8.4 -0.42 1.34e-15 Total body bone mineral density; LUSC cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.7 0.43 1.57e-16 Menopause (age at onset); LUSC trans rs7939886 0.920 rs12224086 chr11:55798259 G/T cg15704280 chr7:45808275 SEPT13 0.79 6.74 0.35 7.14e-11 Myopia (pathological); LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12973672 1.000 rs8101606 chr19:35774556 A/C cg12095397 chr19:35769544 USF2 0.41 6.55 0.34 2.24e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg13560548 chr3:10150139 C3orf24 -0.48 -6.41 -0.33 4.95e-10 Alzheimer's disease; LUSC cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg06026331 chr20:60912101 LAMA5 0.43 5.94 0.31 7.33e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs9378688 1.000 rs9378686 chr6:2217173 G/A cg12303981 chr6:2244766 GMDS -0.5 -5.96 -0.31 6.43e-9 Caudate nucleus volume; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg10729496 chr3:10149963 C3orf24 0.55 6.88 0.35 2.89e-11 Alzheimer's disease; LUSC cis rs10078 0.515 rs6872510 chr5:481610 T/C cg08916839 chr5:415575 AHRR 0.74 6.78 0.35 5.57e-11 Fat distribution (HIV); LUSC cis rs1577917 0.958 rs12191340 chr6:86521400 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.83 -0.43 6.08e-17 Response to antipsychotic treatment; LUSC cis rs7940866 0.801 rs2113929 chr11:130835974 G/A cg12179176 chr11:130786555 SNX19 0.6 9.03 0.44 1.41e-17 Schizophrenia; LUSC cis rs9303401 0.704 rs740605 chr17:56604811 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.51 7.96 0.4 2.78e-14 Cognitive test performance; LUSC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg04756594 chr16:24857601 SLC5A11 0.34 5.66 0.3 3.25e-8 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06670785 chr22:20073572 MIR1306;DGCR8 0.51 6.31 0.33 8.87e-10 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.08 -0.48 4.83e-21 Obesity-related traits; LUSC cis rs11122272 0.701 rs7414807 chr1:231476874 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.41 -0.42 1.23e-15 Hemoglobin concentration; LUSC cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg04267008 chr7:1944627 MAD1L1 0.5 7.63 0.39 2.51e-13 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg21535247 chr6:8435926 SLC35B3 0.59 9.06 0.44 1.09e-17 Motion sickness; LUSC cis rs10992471 0.756 rs3758229 chr9:95078852 G/T cg14631576 chr9:95140430 CENPP -0.36 -6.16 -0.32 2.12e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg26384229 chr12:38710491 ALG10B 0.92 15.89 0.66 9.31e-43 Drug-induced liver injury (flucloxacillin); LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.63 0.6 6.2e-34 Platelet count; LUSC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg09650180 chr20:62225654 GMEB2 -0.66 -9.69 -0.47 1.03e-19 Glioblastoma; LUSC cis rs2729354 1.000 rs2729354 chr11:57355970 A/G cg24343310 chr11:57249947 NA 0.35 6.46 0.33 3.6e-10 Blood protein levels; LUSC cis rs10848704 1.000 rs10848704 chr12:2882544 A/G cg19995117 chr12:2880862 NA -0.6 -11.3 -0.53 2.62e-25 Quantitative traits; LUSC cis rs155346 0.947 rs265160 chr5:139390914 A/C cg01090482 chr5:139365336 NRG2 -0.38 -6.5 -0.34 2.87e-10 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC trans rs1728785 1.000 rs6499181 chr16:68593002 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.22 0.41 4.57e-15 Ulcerative colitis; LUSC cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs459571 0.959 rs410876 chr9:136893867 C/A cg01294253 chr9:136912663 BRD3 0.35 6.07 0.32 3.38e-9 Platelet distribution width; LUSC cis rs72781680 1.000 rs72781649 chr2:24210864 A/G cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs1595825 0.891 rs16824264 chr2:198675917 T/C cg10547527 chr2:198650123 BOLL -0.52 -6.03 -0.31 4.32e-9 Ulcerative colitis; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg18301423 chr5:131593218 PDLIM4 0.37 6.1 0.32 2.94e-9 Blood metabolite levels; LUSC cis rs68170813 0.559 rs1548524 chr7:106944563 G/T cg24556660 chr7:106842632 COG5;HBP1 0.41 5.7 0.3 2.64e-8 Coronary artery disease; LUSC cis rs143626010 1 rs143626010 chr16:28539398 GTGTA/G cg16576597 chr16:28551801 NUPR1 0.3 6.01 0.31 4.73e-9 Mosquito bite size; LUSC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg05855489 chr10:104503620 C10orf26 -0.62 -7.62 -0.38 2.7e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg22800045 chr5:56110881 MAP3K1 0.79 10.53 0.5 1.45e-22 Initial pursuit acceleration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16519440 chr11:65655990 FIBP -0.41 -6.24 -0.32 1.3e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4731207 0.967 rs3807544 chr7:124400705 G/A cg14311320 chr7:124405732 GPR37 0.32 6.14 0.32 2.4e-9 Cutaneous malignant melanoma; LUSC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs12410462 0.681 rs6682883 chr1:227635598 G/A cg23173402 chr1:227635558 NA 0.75 7.96 0.4 2.7e-14 Major depressive disorder; LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.72 0.39 1.36e-13 Prudent dietary pattern; LUSC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.883 rs12366001 chr11:111433916 A/G cg19812747 chr11:111475976 SIK2 0.54 7.79 0.39 8.59e-14 Primary sclerosing cholangitis; LUSC trans rs4729127 1.000 rs57515158 chr7:94007842 T/G cg20086523 chr13:52378287 DHRS12 0.56 6.48 0.33 3.35e-10 Intelligence; LUSC cis rs9815354 0.812 rs73071212 chr3:41981856 C/A cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs709400 0.633 rs3783395 chr14:103895020 T/C cg10523860 chr14:103875565 MARK3 -0.36 -5.67 -0.3 3.14e-8 Body mass index; LUSC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg00745463 chr17:30367425 LRRC37B -0.77 -9.15 -0.45 5.65e-18 Hip circumference adjusted for BMI; LUSC cis rs7647973 1.000 rs3870341 chr3:49584745 A/G cg07636037 chr3:49044803 WDR6 0.69 9.06 0.44 1.1e-17 Menarche (age at onset); LUSC cis rs13385 0.769 rs13178142 chr5:139596552 C/T cg26211634 chr5:139558579 C5orf32 0.49 6.56 0.34 2.05e-10 Atrial fibrillation; LUSC cis rs9393777 0.778 rs13212921 chr6:27205422 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.55 -6.35 -0.33 7.07e-10 Intelligence (multi-trait analysis); LUSC cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg15839431 chr19:19639596 YJEFN3 -0.63 -7.15 -0.36 5.48e-12 Bipolar disorder; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg16606324 chr3:10149918 C3orf24 0.58 8.28 0.41 2.99e-15 Alzheimer's disease; LUSC cis rs6696846 0.936 rs6662930 chr1:205041465 T/C cg21643547 chr1:205240462 TMCC2 -0.39 -6.86 -0.35 3.32e-11 Red blood cell count; LUSC cis rs2970818 0.764 rs61909577 chr12:4568713 G/A cg11146114 chr12:4671731 NA -0.62 -5.87 -0.31 1.03e-8 Phosphorus levels; LUSC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg23205692 chr1:25664452 TMEM50A 0.39 5.8 0.3 1.55e-8 Erythrocyte sedimentation rate; LUSC trans rs2243480 1.000 rs466983 chr7:65520496 T/G cg10756647 chr7:56101905 PSPH 0.85 8.22 0.41 4.44e-15 Diabetic kidney disease; LUSC cis rs9467773 0.620 rs1027203 chr6:26639332 G/C cg09904177 chr6:26538194 HMGN4 0.65 11.47 0.53 6.41e-26 Intelligence (multi-trait analysis); LUSC cis rs61931739 0.500 rs7313094 chr12:34457508 T/C cg06521331 chr12:34319734 NA -0.41 -6.75 -0.35 6.42e-11 Morning vs. evening chronotype; LUSC cis rs3096299 0.802 rs3102336 chr16:89442006 C/T cg06640241 chr16:89574553 SPG7 0.66 9.78 0.47 5.03e-20 Multiple myeloma (IgH translocation); LUSC cis rs6596100 0.538 rs34592321 chr5:132181675 G/C cg02081065 chr5:132209139 LEAP2 -0.62 -5.99 -0.31 5.4e-9 Breast cancer; LUSC trans rs6952808 0.717 rs12534679 chr7:1926745 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.33 0.33 7.73e-10 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.48 0.38 6.75e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg07701084 chr6:150067640 NUP43 0.57 8.69 0.43 1.6e-16 Lung cancer; LUSC trans rs12310956 0.510 rs7302434 chr12:33886819 G/A cg13010199 chr12:38710504 ALG10B 0.45 7.02 0.36 1.21e-11 Morning vs. evening chronotype; LUSC cis rs4474465 1.000 rs10899521 chr11:78184560 T/A cg27205649 chr11:78285834 NARS2 -0.5 -5.85 -0.3 1.16e-8 Alzheimer's disease (survival time); LUSC cis rs2282032 0.550 rs58363992 chr14:90766361 T/C cg04374321 chr14:90722782 PSMC1 0.44 6.06 0.31 3.73e-9 Longevity; LUSC cis rs7119 0.689 rs11630926 chr15:77819582 T/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.39 -0.33 5.48e-10 Type 2 diabetes; LUSC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg15744005 chr10:104629667 AS3MT -0.28 -6.1 -0.32 2.95e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs35306767 0.623 rs72760943 chr10:1143104 G/A cg26597838 chr10:835615 NA 0.53 6.42 0.33 4.6e-10 Eosinophil percentage of granulocytes; LUSC cis rs72781680 0.948 rs113530757 chr2:24142500 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs8060686 0.641 rs12446007 chr16:68189054 C/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10045504 0.502 rs17456635 chr5:38745456 G/A cg15396434 chr5:38725168 NA -0.51 -5.73 -0.3 2.29e-8 Night sleep phenotypes; LUSC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg25427524 chr10:38739819 LOC399744 -0.67 -12.11 -0.55 3.2e-28 Extrinsic epigenetic age acceleration; LUSC cis rs11098499 0.863 rs6853998 chr4:120475860 C/A cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg25554036 chr4:6271136 WFS1 0.61 12.76 0.57 1.23e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7824557 0.701 rs2060465 chr8:11162609 T/C cg27411982 chr8:10470053 RP1L1 0.37 5.84 0.3 1.26e-8 Retinal vascular caliber; LUSC cis rs10743315 0.778 rs7399032 chr12:19371546 T/C cg02471346 chr12:19282374 PLEKHA5 -0.53 -6.68 -0.34 1.01e-10 Gut microbiota (bacterial taxa); LUSC cis rs709400 0.633 rs3783395 chr14:103895020 T/C cg12935359 chr14:103987150 CKB -0.52 -8.03 -0.4 1.68e-14 Body mass index; LUSC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg12963246 chr6:28129442 ZNF389 0.52 7.24 0.37 3.17e-12 Depression; LUSC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg15790184 chr11:494944 RNH1 0.55 5.97 0.31 6.05e-9 Body mass index; LUSC cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg11752832 chr7:134001865 SLC35B4 -0.48 -6.74 -0.35 6.85e-11 Mean platelet volume; LUSC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg09796270 chr17:17721594 SREBF1 0.39 7.05 0.36 1.06e-11 Total body bone mineral density; LUSC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg20887711 chr4:1340912 KIAA1530 0.44 6.64 0.34 1.28e-10 Obesity-related traits; LUSC cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg17509989 chr5:176798049 RGS14 0.69 11.21 0.52 5.78e-25 Hemoglobin concentration;Hematocrit; LUSC cis rs2898681 0.642 rs11538878 chr4:53728524 T/C cg00338735 chr4:53728038 RASL11B 0.41 5.71 0.3 2.49e-8 Optic nerve measurement (cup area); LUSC cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.73 -0.43 1.21e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4253772 0.938 rs10154348 chr22:46638159 C/A cg18190219 chr22:46762943 CELSR1 -0.48 -5.81 -0.3 1.45e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9815354 0.767 rs79323474 chr3:42000973 C/T cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs10751667 0.666 rs7934963 chr11:957220 C/T ch.11.42038R chr11:967971 AP2A2 0.42 6.23 0.32 1.41e-9 Alzheimer's disease (late onset); LUSC cis rs12760731 0.720 rs10798607 chr1:178373110 C/T cg00404053 chr1:178313656 RASAL2 0.64 6.55 0.34 2.22e-10 Obesity-related traits; LUSC cis rs9326248 0.813 rs588534 chr11:117068504 A/G cg16524733 chr11:117070046 TAGLN 0.37 5.8 0.3 1.55e-8 Blood protein levels; LUSC cis rs10197940 0.648 rs7587301 chr2:152347600 A/G cg19508488 chr2:152266495 RIF1 0.4 5.85 0.3 1.17e-8 Lung cancer; LUSC cis rs1371867 0.817 rs1788208 chr8:101312515 T/C cg06002616 chr8:101225028 SPAG1 -0.46 -7.57 -0.38 3.77e-13 Atrioventricular conduction; LUSC trans rs6951245 1.000 rs11763793 chr7:1094342 A/G cg13565492 chr6:43139072 SRF -0.61 -6.4 -0.33 5.21e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs826838 0.935 rs10875816 chr12:38955014 C/A cg26384229 chr12:38710491 ALG10B 0.9 16.79 0.68 2.6e-46 Heart rate; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg22638593 chr5:131593259 PDLIM4 0.36 5.79 0.3 1.61e-8 Blood metabolite levels; LUSC cis rs7312933 0.567 rs11181399 chr12:42666412 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.51 7.19 0.37 4.33e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.05 0.48 6.03e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs8062405 1.000 rs62036621 chr16:28833299 C/A cg09754948 chr16:28834200 ATXN2L 0.44 6.43 0.33 4.51e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg11663144 chr21:46675770 NA -0.42 -7.3 -0.37 2.07e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9311676 0.632 rs11705721 chr3:58400414 T/C cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.47e-12 Lung disease severity in cystic fibrosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20087303 chr14:70233840 SFRS5;LOC100289511 0.45 6.1 0.32 2.86e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6696846 0.765 rs61822619 chr1:205090885 C/G cg21545522 chr1:205238299 TMCC2 0.46 8.52 0.42 5.56e-16 Red blood cell count; LUSC cis rs2073300 1.000 rs12625999 chr20:23442085 A/G cg12062639 chr20:23401060 NAPB -0.78 -6.02 -0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9952991 0.882 rs2847274 chr18:12777603 T/C cg23598886 chr18:12777645 NA 0.65 6.6 0.34 1.61e-10 Inflammatory skin disease; LUSC cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.63 0.47 1.62e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4595586 0.525 rs11611705 chr12:39426828 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.53 0.38 4.8e-13 Morning vs. evening chronotype; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06190380 chr10:64576262 EGR2 0.75 6.38 0.33 5.9e-10 Cognitive performance; LUSC trans rs9860340 0.730 rs55641563 chr3:87649547 T/C cg03644585 chr7:884825 UNC84A 0.43 6.06 0.31 3.67e-9 Electroencephalographic traits in alcoholism; LUSC cis rs4820539 0.902 rs9612237 chr22:23472954 T/C cg14186256 chr22:23484241 RTDR1 0.95 17.97 0.7 5.23e-51 Bone mineral density; LUSC cis rs2439831 1.000 rs2584725 chr15:43793135 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs7106204 0.764 rs57490470 chr11:24234370 A/G ch.11.24196551F chr11:24239977 NA 0.97 9.03 0.44 1.36e-17 Response to Homoharringtonine (cytotoxicity); LUSC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg00750074 chr16:89608354 SPG7 -0.56 -10.25 -0.49 1.29e-21 Multiple myeloma (IgH translocation); LUSC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg22875332 chr1:76189707 ACADM 0.83 14.06 0.61 1.39e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4363385 0.818 rs3806223 chr1:153002646 T/C cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs10276381 0.786 rs10255700 chr7:28220228 C/T cg23620719 chr7:28220237 JAZF1 0.63 6.76 0.35 6.21e-11 Crohn's disease; LUSC cis rs7605827 0.930 rs1986279 chr2:15617390 G/A cg19274914 chr2:15703543 NA 0.48 9.23 0.45 3.1e-18 Educational attainment (years of education); LUSC trans rs9329221 0.698 rs12547997 chr8:10260837 A/G cg15556689 chr8:8085844 FLJ10661 0.58 8.15 0.41 7.54e-15 Neuroticism; LUSC trans rs11165623 0.602 rs12120893 chr1:97007132 C/T cg03325851 chr11:6440480 APBB1 0.47 6.07 0.32 3.42e-9 Hip circumference;Waist circumference; LUSC cis rs2882667 0.690 rs160401 chr5:138061341 C/T cg04439458 chr5:138467593 SIL1 0.36 6.99 0.36 1.46e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4474465 0.915 rs12288436 chr11:78161430 T/C cg27205649 chr11:78285834 NARS2 -0.5 -5.89 -0.31 9.6e-9 Alzheimer's disease (survival time); LUSC cis rs453301 0.686 rs7814328 chr8:8876229 T/C cg15556689 chr8:8085844 FLJ10661 -0.61 -9.32 -0.45 1.68e-18 Joint mobility (Beighton score); LUSC cis rs34779708 0.931 rs4934533 chr10:35359619 A/G cg04310649 chr10:35416472 CREM -0.41 -6.44 -0.33 4.26e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg09904177 chr6:26538194 HMGN4 -0.5 -7.94 -0.4 3.01e-14 Schizophrenia; LUSC cis rs6960043 0.738 rs12538043 chr7:15058998 C/G cg19272540 chr7:15055459 NA 0.35 8.22 0.41 4.67e-15 Type 2 diabetes; LUSC cis rs2562456 0.917 rs2681392 chr19:21695987 T/G cg00806126 chr19:22604979 ZNF98 0.37 5.71 0.3 2.5e-8 Pain; LUSC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Tonsillectomy; LUSC cis rs1775715 0.707 rs2808073 chr10:32179275 A/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.5 0.34 2.88e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs3858526 0.834 rs7129481 chr11:5991114 G/T cg25319279 chr11:5960081 NA -0.43 -5.98 -0.31 5.6e-9 DNA methylation (variation); LUSC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs3808502 0.527 rs2736389 chr8:11161310 C/A cg15556689 chr8:8085844 FLJ10661 0.43 6.17 0.32 1.93e-9 Neuroticism; LUSC cis rs9300255 0.537 rs1619561 chr12:123620268 G/C cg05973401 chr12:123451056 ABCB9 0.54 6.68 0.34 9.72e-11 Neutrophil percentage of white cells; LUSC cis rs4664308 0.618 rs66667042 chr2:160886703 A/C cg03641300 chr2:160917029 PLA2R1 -0.48 -7.96 -0.4 2.79e-14 Idiopathic membranous nephropathy; LUSC trans rs1997103 1.000 rs4947500 chr7:55407270 C/A cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7223966 1.000 rs9899491 chr17:61934384 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.78 0.35 5.4e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs41271473 1.000 rs41270187 chr1:228878871 T/C cg16512390 chr1:228756714 NA 0.46 5.71 0.3 2.5e-8 Chronic lymphocytic leukemia; LUSC cis rs12980942 0.935 rs34075897 chr19:41826598 A/G cg25627403 chr19:41769009 HNRNPUL1 0.55 5.94 0.31 7.27e-9 Coronary artery disease; LUSC cis rs1865760 1.000 rs2071299 chr6:25914801 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 6.78 0.35 5.41e-11 Height; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25289973 chr4:41362397 LIMCH1 -0.38 -6.37 -0.33 6.15e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15367106 chr12:96184558 NTN4 -0.44 -6.3 -0.33 9.61e-10 Electrocardiographic conduction measures; LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs921968 0.565 rs6708192 chr2:219592227 A/G cg02176678 chr2:219576539 TTLL4 -0.59 -10.47 -0.5 2.24e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.69 -0.5 3.93e-23 Alzheimer's disease; LUSC cis rs11711311 1.000 rs9848993 chr3:113497914 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.88 -0.31 1.02e-8 IgG glycosylation; LUSC cis rs7927592 0.913 rs11228287 chr11:68349754 A/G cg01657329 chr11:68192670 LRP5 -0.4 -5.77 -0.3 1.85e-8 Total body bone mineral density; LUSC cis rs12618769 0.597 rs3769741 chr2:99068204 G/T cg10123293 chr2:99228465 UNC50 0.45 7.62 0.38 2.59e-13 Bipolar disorder; LUSC cis rs5758511 0.680 rs5758662 chr22:42628088 T/C cg00645731 chr22:42541494 CYP2D7P1 0.58 10.21 0.49 1.8e-21 Birth weight; LUSC cis rs5009270 0.512 rs1024411 chr7:112247692 G/A cg23628563 chr7:112262597 NA 0.43 5.97 0.31 6.01e-9 Osteoarthritis (hip); LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg22963979 chr7:1858916 MAD1L1 -0.57 -8.88 -0.44 4.24e-17 Bipolar disorder and schizophrenia; LUSC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg17971929 chr21:40555470 PSMG1 0.48 6.93 0.35 2.14e-11 Menarche (age at onset); LUSC cis rs897984 0.609 rs11862744 chr16:31057800 G/A cg02466173 chr16:30829666 NA -0.53 -10.36 -0.49 5.3e-22 Dementia with Lewy bodies; LUSC cis rs12900413 0.631 rs62023455 chr15:90301999 G/A cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg11812906 chr14:75593930 NEK9 -0.67 -11.34 -0.53 1.89e-25 Height; LUSC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg02428538 chr16:24856791 SLC5A11 0.5 5.75 0.3 1.98e-8 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg11494091 chr17:61959527 GH2 0.65 13.68 0.6 4.06e-34 Prudent dietary pattern; LUSC cis rs7587476 0.736 rs62202002 chr2:215690600 T/C cg04004882 chr2:215674386 BARD1 0.48 6.37 0.33 6.34e-10 Neuroblastoma; LUSC cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg20701182 chr2:24300061 SF3B14 0.89 11.69 0.54 1.08e-26 Lymphocyte counts; LUSC cis rs12893668 0.703 rs4906338 chr14:104050357 A/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -5.97 -0.31 5.94e-9 Reticulocyte count; LUSC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg21573476 chr21:45109991 RRP1B -0.36 -5.75 -0.3 2.02e-8 Mean corpuscular volume; LUSC cis rs2455601 1.000 rs11042114 chr11:8919889 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.88 -0.35 3.02e-11 Schizophrenia; LUSC cis rs4268898 0.965 rs4665673 chr2:24459737 A/T cg06627628 chr2:24431161 ITSN2 0.61 8.96 0.44 2.27e-17 Asthma; LUSC cis rs11711311 0.955 rs9866806 chr3:113379865 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 0.48 6.62 0.34 1.42e-10 IgG glycosylation; LUSC cis rs12410462 0.681 rs6681096 chr1:227609720 G/A cg04117972 chr1:227635322 NA 0.74 7.79 0.39 8.75e-14 Major depressive disorder; LUSC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.68 -11.38 -0.53 1.43e-25 Total body bone mineral density; LUSC cis rs9640161 0.830 rs1051760 chr7:150070630 A/G cg21361702 chr7:150065534 REPIN1 0.6 9.29 0.45 2.09e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs868036 0.672 rs7175517 chr15:68077630 A/G cg24579218 chr15:68104479 NA -0.36 -6.45 -0.33 4.01e-10 Restless legs syndrome; LUSC cis rs7809950 1.000 rs2107713 chr7:107232369 C/T cg23024343 chr7:107201750 COG5 -0.51 -7.85 -0.39 5.55e-14 Coronary artery disease; LUSC cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg03146154 chr1:46216737 IPP -0.55 -8.02 -0.4 1.79e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg05738196 chr6:26577821 NA 0.58 6.78 0.35 5.58e-11 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.525 rs35046524 chr12:39414535 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.4 0.33 5.12e-10 Morning vs. evening chronotype; LUSC cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs11779988 0.545 rs431961 chr8:17786204 T/G cg01800426 chr8:17659068 MTUS1 -0.46 -5.7 -0.3 2.64e-8 Breast cancer; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg04141948 chr7:1023156 CYP2W1 0.27 5.77 0.3 1.8e-8 Longevity;Endometriosis; LUSC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg23985595 chr17:80112537 CCDC57 0.3 5.76 0.3 1.92e-8 Life satisfaction; LUSC cis rs748404 0.578 rs478028 chr15:43610772 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.47 6.6 0.34 1.63e-10 Lung cancer; LUSC cis rs9914988 0.943 rs12453504 chr17:27119524 C/A cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs6598955 0.543 rs79778574 chr1:26538482 A/G cg12744634 chr1:26560303 CCDC21 0.39 5.84 0.3 1.25e-8 Obesity-related traits; LUSC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg02569458 chr12:86230093 RASSF9 0.54 8.82 0.43 6.7e-17 Major depressive disorder; LUSC cis rs10197940 0.662 rs13555 chr2:152333304 C/A cg19508488 chr2:152266495 RIF1 0.44 6.33 0.33 8.07e-10 Lung cancer; LUSC cis rs155346 1.000 rs155346 chr5:139390377 C/T cg01090482 chr5:139365336 NRG2 0.37 6.36 0.33 6.71e-10 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21937244 chr14:103406412 CDC42BPB -0.36 -6.61 -0.34 1.56e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.7 0.47 9.26e-20 Bipolar disorder; LUSC cis rs9398803 0.799 rs1538170 chr6:126752874 C/T cg19875578 chr6:126661172 C6orf173 0.41 5.96 0.31 6.26e-9 Male-pattern baldness; LUSC cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg08807101 chr21:30365312 RNF160 -0.76 -13.64 -0.6 5.41e-34 Dental caries; LUSC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg11247378 chr22:39784982 NA -0.68 -13.63 -0.6 6.14e-34 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg24881330 chr22:46731750 TRMU 0.88 8.87 0.44 4.44e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs7247513 0.897 rs12979146 chr19:12717904 C/T cg01871581 chr19:12707946 ZNF490 -0.6 -9.62 -0.47 1.73e-19 Bipolar disorder; LUSC cis rs1595825 0.838 rs79381203 chr2:198573762 A/G cg00982548 chr2:198649783 BOLL -0.53 -6.72 -0.35 7.65e-11 Ulcerative colitis; LUSC cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg24558204 chr6:135376177 HBS1L 0.68 10.81 0.51 1.43e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs651907 0.535 rs9830943 chr3:101428899 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.04 0.36 1.1e-11 Colorectal cancer; LUSC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg12463550 chr7:65579703 CRCP 0.55 8.21 0.41 4.85e-15 Aortic root size; LUSC cis rs500891 0.525 rs3778205 chr6:84060477 G/T cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.08e-14 Platelet-derived growth factor BB levels; LUSC trans rs57221529 0.766 rs72706606 chr5:558609 T/C cg25482853 chr8:67687455 SGK3 1.19 19.12 0.72 1.43e-55 Lung disease severity in cystic fibrosis; LUSC cis rs7666738 0.712 rs11731393 chr4:98859070 G/C cg03676636 chr4:99064102 C4orf37 0.34 6.13 0.32 2.47e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9937943 0.667 rs12919002 chr16:74612377 A/G cg01733217 chr16:74700730 RFWD3 0.62 6.78 0.35 5.3e-11 Neutrophil percentage of white cells; LUSC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg10909506 chr17:38081995 ORMDL3 0.35 6.61 0.34 1.57e-10 Self-reported allergy; LUSC trans rs2679649 1.000 rs2260078 chr6:122350567 C/T cg00167820 chr8:131663355 NA 0.54 6.32 0.33 8.2e-10 Subcutaneous adipose tissue; LUSC cis rs6741892 1.000 rs13006376 chr2:38914251 A/C cg23643435 chr2:38893251 GALM -0.7 -5.71 -0.3 2.56e-8 5-HTT brain serotonin transporter levels; LUSC cis rs12310956 0.532 rs7967627 chr12:33974669 G/T cg06521331 chr12:34319734 NA -0.47 -7.54 -0.38 4.38e-13 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.42 0.33 4.79e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 7.32 0.37 1.81e-12 Hip circumference adjusted for BMI; LUSC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs3741404 0.512 rs4980504 chr11:63873083 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.62 -9.62 -0.47 1.64e-19 Platelet count; LUSC trans rs11039798 0.588 rs12278284 chr11:48612063 G/C cg15704280 chr7:45808275 SEPT13 0.64 7.08 0.36 8.52e-12 Axial length; LUSC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg10523679 chr1:76189770 ACADM 0.89 14.12 0.61 8.05e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11039100 1.000 rs12362071 chr11:5828450 T/C cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg24596788 chr1:163392923 NA -0.45 -7.45 -0.38 7.88e-13 Motion sickness; LUSC cis rs1009647 0.645 rs72715709 chr14:55711692 C/T cg04306507 chr14:55594613 LGALS3 0.44 5.98 0.31 5.72e-9 Testicular germ cell tumor; LUSC cis rs921968 0.643 rs484085 chr2:219396684 C/T cg02176678 chr2:219576539 TTLL4 0.64 11.7 0.54 9.61e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg00409905 chr10:38381863 ZNF37A -0.35 -6.14 -0.32 2.35e-9 Extrinsic epigenetic age acceleration; LUSC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg08499158 chr17:42289980 UBTF 0.48 8.24 0.41 3.95e-15 Total body bone mineral density; LUSC cis rs4771122 0.740 rs1006353 chr13:28047269 A/G cg01674679 chr13:27998804 GTF3A 0.42 5.82 0.3 1.39e-8 Body mass index; LUSC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.27 -0.32 1.1e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs8113142 0.559 rs73028028 chr19:29137876 T/C cg04546413 chr19:29218101 NA 0.41 5.76 0.3 1.95e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs2115630 0.967 rs12595786 chr15:85336670 T/C cg11189052 chr15:85197271 WDR73 -0.43 -6.25 -0.32 1.22e-9 P wave terminal force; LUSC cis rs3806843 1.000 rs7732179 chr5:140199039 G/A cg19875535 chr5:140030758 IK 0.5 7.96 0.4 2.63e-14 Depressive symptoms (multi-trait analysis); LUSC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg03929089 chr4:120376271 NA -1.03 -19.79 -0.73 3.14e-58 Height; LUSC cis rs3857536 0.704 rs4710570 chr6:66890244 A/G cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg14159672 chr1:205819179 PM20D1 0.8 13.73 0.6 2.43e-34 Menarche (age at onset); LUSC cis rs4925386 0.921 rs11204472 chr20:60920887 G/A cg24112000 chr20:60950667 NA 0.36 6.8 0.35 4.72e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs3742264 0.656 rs4460970 chr13:46540293 A/T cg15192986 chr13:46630673 CPB2 -0.37 -5.65 -0.3 3.37e-8 Blood protein levels; LUSC cis rs9322817 0.691 rs2486136 chr6:105285759 C/T cg02098413 chr6:105308735 HACE1 0.27 5.66 0.3 3.21e-8 Thyroid stimulating hormone; LUSC cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg27129171 chr3:47204927 SETD2 0.69 11.48 0.53 6.36e-26 Colorectal cancer; LUSC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.77 10.35 0.49 5.71e-22 Gut microbiome composition (summer); LUSC cis rs61935443 0.614 rs11107787 chr12:95311669 C/T cg21533806 chr12:95267307 NA 0.49 5.74 0.3 2.12e-8 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00734800 chr3:50388182 TUSC4;CYB561D2 0.44 6.53 0.34 2.39e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg09165964 chr15:75287851 SCAMP5 0.54 7.84 0.39 6.21e-14 Breast cancer; LUSC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.79 0.78 5.28e-70 Height; LUSC cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg03146154 chr1:46216737 IPP 0.56 8.36 0.42 1.77e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg08742575 chr21:47604166 C21orf56 0.47 7.12 0.36 6.64e-12 Testicular germ cell tumor; LUSC cis rs11785693 0.862 rs73183606 chr8:4986999 C/T cg26367366 chr8:4980734 NA 0.79 9.32 0.45 1.64e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg18132916 chr6:79620363 NA -0.38 -5.85 -0.3 1.18e-8 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.733 rs3936503 chr10:35549257 A/G cg03585969 chr10:35415529 CREM -0.52 -7.31 -0.37 1.97e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg18876405 chr7:65276391 NA 0.54 8.27 0.41 3.22e-15 Aortic root size; LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.51 0.46 3.94e-19 Bipolar disorder; LUSC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg02269571 chr22:50332266 NA -0.4 -6.22 -0.32 1.45e-9 Schizophrenia; LUSC cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg27279351 chr12:120934652 DYNLL1 0.63 8.44 0.42 9.92e-16 High light scatter reticulocyte count; LUSC trans rs9329221 0.736 rs12548025 chr8:10260921 A/T cg15556689 chr8:8085844 FLJ10661 0.56 7.69 0.39 1.67e-13 Neuroticism; LUSC cis rs834603 0.575 rs2462638 chr7:47471286 A/G cg09696706 chr7:47479511 TNS3 0.32 5.83 0.3 1.31e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg11062466 chr8:58055876 NA 0.48 6.26 0.32 1.16e-9 Developmental language disorder (linguistic errors); LUSC cis rs8040855 0.599 rs6496793 chr15:85725746 T/A cg04831495 chr15:85060580 GOLGA6L5 0.41 6.87 0.35 3.1e-11 Bulimia nervosa; LUSC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg17524180 chr13:113633600 MCF2L -0.34 -6.6 -0.34 1.65e-10 Systolic blood pressure; LUSC cis rs870825 0.616 rs6814278 chr4:185644417 G/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg18681998 chr4:17616180 MED28 0.85 15.84 0.65 1.54e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs2018683 0.683 rs12538606 chr7:28969408 T/C cg19402173 chr7:128379420 CALU -0.46 -6.92 -0.35 2.28e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs12681288 0.640 rs6985741 chr8:962858 C/T cg04851639 chr8:1020857 NA -0.37 -7.1 -0.36 7.61e-12 Schizophrenia; LUSC cis rs9326248 0.861 rs11216172 chr11:116749878 G/A cg20608306 chr11:116969690 SIK3 0.4 6.57 0.34 1.95e-10 Blood protein levels; LUSC cis rs981844 0.683 rs1105495 chr4:154756867 T/C cg14289246 chr4:154710475 SFRP2 -0.47 -6.51 -0.34 2.69e-10 Response to statins (LDL cholesterol change); LUSC cis rs6546886 0.957 rs4416242 chr2:74259894 A/T cg14702570 chr2:74259524 NA -0.31 -5.91 -0.31 8.36e-9 Dialysis-related mortality; LUSC cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg08807101 chr21:30365312 RNF160 0.75 13.45 0.59 2.93e-33 Dental caries; LUSC cis rs734999 0.545 rs10910111 chr1:2542653 A/G cg18932078 chr1:2524107 MMEL1 0.28 6.2 0.32 1.68e-9 Ulcerative colitis; LUSC trans rs11098499 0.754 rs4107728 chr4:120253910 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.49 0.33 3.12e-10 Corneal astigmatism; LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg02353165 chr6:42928485 GNMT 0.67 11.53 0.53 4.18e-26 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11166629 1.000 rs2315838 chr8:135645968 C/T cg21672855 chr8:135614777 ZFAT 0.35 5.72 0.3 2.32e-8 Smoking quantity; LUSC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg03233332 chr7:66118400 NA 0.4 5.87 0.31 1.06e-8 Aortic root size; LUSC cis rs2692947 0.673 rs3111873 chr2:96781986 G/C cg22654517 chr2:96458247 NA -0.31 -5.77 -0.3 1.78e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4555082 0.915 rs28594491 chr14:105758018 G/A cg27165867 chr14:105738592 BRF1 -0.51 -7.43 -0.38 9.37e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg07092213 chr7:1199455 ZFAND2A -0.43 -6.62 -0.34 1.47e-10 Longevity;Endometriosis; LUSC cis rs3125734 0.660 rs10733769 chr10:63974255 G/T cg19640130 chr10:64028056 RTKN2 -0.42 -7.46 -0.38 7.6e-13 Rheumatoid arthritis; LUSC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg15744005 chr10:104629667 AS3MT -0.38 -7.81 -0.39 7.65e-14 Arsenic metabolism; LUSC cis rs12410462 0.579 rs77529417 chr1:227547895 T/C cg04117972 chr1:227635322 NA 0.62 6.74 0.35 7.04e-11 Major depressive disorder; LUSC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs7592578 0.771 rs12052514 chr2:191378170 C/T cg11845111 chr2:191398756 TMEM194B -0.85 -10.9 -0.51 6.98e-24 Diastolic blood pressure; LUSC trans rs7951105 1.000 rs7104592 chr11:39242244 C/A cg24085930 chr3:21832523 NA 0.49 6.07 0.32 3.42e-9 Free thyroxine concentration; LUSC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7633770 0.841 rs11130100 chr3:46679198 A/T cg11219411 chr3:46661640 NA -0.38 -7.57 -0.38 3.68e-13 Coronary artery disease; LUSC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg11812906 chr14:75593930 NEK9 0.67 11.68 0.54 1.14e-26 Height; LUSC trans rs34421088 0.532 rs3808515 chr8:11156041 C/T cg06636001 chr8:8085503 FLJ10661 0.43 6.44 0.33 4.22e-10 Neuroticism; LUSC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg01191920 chr7:158217561 PTPRN2 -0.59 -12.32 -0.56 5.24e-29 Obesity-related traits; LUSC cis rs5758659 1.000 rs5751255 chr22:42648408 C/T cg15557168 chr22:42548783 NA -0.43 -7.27 -0.37 2.62e-12 Cognitive function; LUSC cis rs73206853 0.686 rs7974047 chr12:111119631 C/T cg12870014 chr12:110450643 ANKRD13A 0.61 6.17 0.32 1.97e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -5.95 -0.31 6.62e-9 Developmental language disorder (linguistic errors); LUSC cis rs3770081 1.000 rs75713195 chr2:86290659 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC cis rs12681287 0.577 rs13257414 chr8:87494138 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.24 -0.37 3.19e-12 Caudate activity during reward; LUSC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.07e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9807841 0.670 rs10948 chr19:10754905 G/T cg09936142 chr19:10668400 KRI1 -0.42 -6.58 -0.34 1.81e-10 Inflammatory skin disease; LUSC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs2439831 0.867 rs3101443 chr15:43912372 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC cis rs7659604 0.502 rs10013916 chr4:122702179 T/G cg06713675 chr4:122721982 EXOSC9 0.37 6.07 0.32 3.54e-9 Type 2 diabetes; LUSC cis rs73198271 0.531 rs56100346 chr8:8652844 C/T cg01851573 chr8:8652454 MFHAS1 0.58 7.72 0.39 1.34e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg25554036 chr4:6271136 WFS1 0.62 13.45 0.59 2.88e-33 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6977660 0.714 rs12672320 chr7:19813594 G/T cg07541023 chr7:19748670 TWISTNB 0.67 7.24 0.37 3.2e-12 Thyroid stimulating hormone; LUSC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg11752832 chr7:134001865 SLC35B4 0.59 9.53 0.46 3.26e-19 Mean platelet volume; LUSC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6545883 0.868 rs2441381 chr2:61798829 C/T cg15711740 chr2:61764176 XPO1 -0.45 -7.12 -0.36 6.51e-12 Tuberculosis; LUSC cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.69 0.6 3.62e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1595825 0.732 rs77357334 chr2:198455607 G/A cg00982548 chr2:198649783 BOLL -0.53 -6.2 -0.32 1.65e-9 Ulcerative colitis; LUSC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg15704280 chr7:45808275 SEPT13 -0.51 -7.04 -0.36 1.07e-11 HDL cholesterol; LUSC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg22834771 chr12:69754056 YEATS4 -0.45 -6.39 -0.33 5.49e-10 Blood protein levels; LUSC cis rs6938 0.534 rs11854704 chr15:75221015 C/T cg10253484 chr15:75165896 SCAMP2 -0.49 -7.21 -0.37 3.75e-12 Breast cancer; LUSC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg06634786 chr22:41940651 POLR3H -0.53 -6.45 -0.33 3.85e-10 Vitiligo; LUSC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg08219700 chr8:58056026 NA 0.49 6.06 0.31 3.73e-9 Developmental language disorder (linguistic errors); LUSC cis rs911555 0.723 rs2273701 chr14:103923225 G/T cg12935359 chr14:103987150 CKB 0.66 10.79 0.51 1.81e-23 Intelligence (multi-trait analysis); LUSC cis rs951366 0.539 rs1935025 chr1:205692084 C/A cg24503407 chr1:205819492 PM20D1 -0.47 -6.32 -0.33 8.32e-10 Menarche (age at onset); LUSC cis rs9807841 0.592 rs6511707 chr19:10767790 C/T cg09936142 chr19:10668400 KRI1 -0.39 -6.25 -0.32 1.22e-9 Inflammatory skin disease; LUSC cis rs2970818 0.831 rs11063217 chr12:4650782 G/A cg11146114 chr12:4671731 NA -0.6 -5.99 -0.31 5.42e-9 Phosphorus levels; LUSC trans rs10435719 0.867 rs62493601 chr8:11788307 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.05 0.31 3.87e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg27170947 chr2:26402098 FAM59B 0.72 10.82 0.51 1.41e-23 Gut microbiome composition (summer); LUSC cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -7.31 -0.37 2.03e-12 Menarche (age at onset); LUSC cis rs2758596 1.000 rs2842866 chr1:156159721 G/A cg24450063 chr1:156163899 SLC25A44 1.04 8.47 0.42 7.73e-16 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs10843647 0.967 rs1973269 chr12:30323516 A/C cg12718339 chr12:29936407 TMTC1 -0.36 -5.91 -0.31 8.54e-9 Glucose homeostasis traits; LUSC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.07 -0.4 1.31e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs117352156 0.943 rs10826543 chr10:29220500 C/T cg06394621 chr10:29236369 NA -0.45 -5.91 -0.31 8.29e-9 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs2806561 0.765 rs2806565 chr1:23507068 A/G cg19743168 chr1:23544995 NA 0.41 7.94 0.4 3.14e-14 Height; LUSC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg23548719 chr3:101395035 LOC100009676;ZBTB11 -0.45 -5.96 -0.31 6.57e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg20811857 chr17:78079795 GAA -0.32 -5.9 -0.31 8.98e-9 Yeast infection; LUSC cis rs11250098 0.583 rs66724331 chr8:10789345 C/A cg27411982 chr8:10470053 RP1L1 -0.49 -7.47 -0.38 7.29e-13 Morning vs. evening chronotype; LUSC cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg08213375 chr14:104286397 PPP1R13B 0.44 7.91 0.4 3.73e-14 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs17401966 0.540 rs6674949 chr1:10458480 A/G cg19773385 chr1:10388646 KIF1B -0.4 -7.2 -0.37 3.96e-12 Hepatocellular carcinoma; LUSC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.83 -0.35 4.1e-11 Lung cancer; LUSC trans rs7824557 0.933 rs6601576 chr8:11100275 A/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.69 -0.34 9.38e-11 Retinal vascular caliber; LUSC cis rs16854884 0.657 rs1867608 chr3:143752938 G/A cg06585982 chr3:143692056 C3orf58 0.5 7.88 0.4 4.71e-14 Economic and political preferences (feminism/equality); LUSC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.28 0.59 1.26e-32 Total body bone mineral density; LUSC cis rs6554196 0.508 rs11727273 chr4:55509748 C/T cg18836493 chr4:55524333 KIT -0.41 -7.02 -0.36 1.26e-11 Monocyte count; LUSC cis rs459571 0.920 rs433402 chr9:136898627 A/G cg01294253 chr9:136912663 BRD3 0.34 5.73 0.3 2.29e-8 Platelet distribution width; LUSC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.76 0.3 1.86e-8 Tonsillectomy; LUSC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg11189052 chr15:85197271 WDR73 -0.52 -7.3 -0.37 2.1e-12 P wave terminal force; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19260885 chr1:113162159 ST7L;CAPZA1 -0.41 -6.14 -0.32 2.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11992162 0.591 rs4240678 chr8:11802426 C/T cg21775007 chr8:11205619 TDH -0.44 -6.28 -0.32 1.08e-9 Monocyte count; LUSC cis rs7760949 0.852 rs9475800 chr6:13932230 A/G cg27413430 chr6:13925136 RNF182 0.61 9.01 0.44 1.61e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs11864453 0.713 rs7191127 chr16:72123992 G/T cg01557791 chr16:72042693 DHODH -0.52 -7.54 -0.38 4.42e-13 Fibrinogen levels; LUSC cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs7824557 0.527 rs2572446 chr8:11239565 C/T cg12568669 chr8:11666485 FDFT1 0.26 5.78 0.3 1.72e-8 Retinal vascular caliber; LUSC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg00033643 chr7:134001901 SLC35B4 0.47 7.3 0.37 2.15e-12 Mean platelet volume; LUSC cis rs9323205 0.954 rs4258524 chr14:51638739 A/T cg23942311 chr14:51606299 NA -0.41 -8.77 -0.43 9.5e-17 Cancer; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C ch.3.55501R chr3:3184210 TRNT1 0.35 6.07 0.32 3.43e-9 Tuberculosis; LUSC cis rs753778 0.602 rs9792 chr8:142205237 C/T cg18755752 chr8:142205143 DENND3 0.76 13.77 0.6 1.83e-34 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs11785400 0.963 rs9771845 chr8:143726577 C/G cg24634471 chr8:143751801 JRK 0.59 8.97 0.44 2.2e-17 Schizophrenia; LUSC cis rs6519955 0.796 rs4072455 chr22:46422938 T/C cg23691090 chr22:46449981 C22orf26;LOC150381 0.4 6.09 0.32 3.15e-9 Dupuytren's disease; LUSC cis rs1595825 0.732 rs79207930 chr2:198423111 G/T cg00982548 chr2:198649783 BOLL -0.51 -6.23 -0.32 1.44e-9 Ulcerative colitis; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg11062466 chr8:58055876 NA 0.65 8.6 0.43 3.23e-16 Developmental language disorder (linguistic errors); LUSC cis rs782590 0.608 rs10207590 chr2:55921782 G/C cg03859395 chr2:55845619 SMEK2 -0.74 -11.83 -0.54 3.33e-27 Metabolic syndrome; LUSC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg06454157 chr6:167490870 NA -0.26 -6.09 -0.32 3.17e-9 Crohn's disease; LUSC cis rs6469656 0.881 rs4335152 chr8:117651371 A/G cg24004040 chr8:117650383 NA -0.43 -6.22 -0.32 1.46e-9 Colorectal cancer; LUSC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg22862634 chr11:62369728 EML3;MTA2 0.59 9.28 0.45 2.23e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs477692 0.699 rs509017 chr10:131367174 T/G cg26102564 chr10:131424627 MGMT 0.4 6.02 0.31 4.68e-9 Response to temozolomide; LUSC cis rs1018836 0.892 rs10105142 chr8:91547420 C/T cg16814680 chr8:91681699 NA -0.65 -10.75 -0.51 2.47e-23 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg25456477 chr12:86230367 RASSF9 0.33 5.73 0.3 2.21e-8 Major depressive disorder; LUSC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg09365446 chr1:150670422 GOLPH3L -0.4 -5.94 -0.31 7.35e-9 Tonsillectomy; LUSC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg18876405 chr7:65276391 NA -0.58 -9.31 -0.45 1.8e-18 Aortic root size; LUSC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg23283495 chr1:209979779 IRF6 0.69 7.96 0.4 2.69e-14 Cleft lip with or without cleft palate; LUSC cis rs4242434 0.927 rs7843828 chr8:22463623 C/T cg03733263 chr8:22462867 KIAA1967 0.99 18.35 0.71 1.72e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs73198271 0.515 rs11906 chr8:8641259 C/T cg01851573 chr8:8652454 MFHAS1 0.57 6.86 0.35 3.43e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9837602 1.000 rs6806178 chr3:99780393 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -6.03 -0.31 4.47e-9 Breast cancer; LUSC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg22508957 chr16:3507546 NAT15 -0.66 -10.33 -0.49 6.98e-22 Tuberculosis; LUSC cis rs6906287 0.609 rs10457342 chr6:118948033 A/G cg21191810 chr6:118973309 C6orf204 0.32 5.81 0.3 1.45e-8 Electrocardiographic conduction measures; LUSC cis rs2624839 0.679 rs2624835 chr3:50209049 G/A cg14019146 chr3:50243930 SLC38A3 -0.53 -12.75 -0.57 1.28e-30 Intelligence (multi-trait analysis); LUSC cis rs7659604 0.540 rs10007956 chr4:122700669 A/T cg06713675 chr4:122721982 EXOSC9 0.35 5.77 0.3 1.78e-8 Type 2 diabetes; LUSC cis rs977987 0.806 rs11149833 chr16:75464002 G/C cg03315344 chr16:75512273 CHST6 0.5 9.55 0.46 2.98e-19 Dupuytren's disease; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg07703079 chr11:430292 ANO9 0.66 6.75 0.35 6.51e-11 Body mass index; LUSC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg13798780 chr7:105162888 PUS7 0.55 5.72 0.3 2.34e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6938 0.534 rs11854704 chr15:75221015 C/T cg03289416 chr15:75166202 SCAMP2 0.45 6.99 0.36 1.5e-11 Breast cancer; LUSC trans rs34421088 0.532 rs2409754 chr8:11155613 A/G cg06636001 chr8:8085503 FLJ10661 0.44 6.58 0.34 1.8e-10 Neuroticism; LUSC cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC cis rs2898290 0.622 rs11250140 chr8:11346592 A/C cg21775007 chr8:11205619 TDH -0.5 -7.54 -0.38 4.51e-13 Systolic blood pressure; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22837499 chr11:18417924 LDHA -0.46 -6.09 -0.32 3.12e-9 Hepatitis; LUSC trans rs12310956 0.532 rs10844715 chr12:33968444 A/G cg13010199 chr12:38710504 ALG10B 0.49 7.44 0.38 8.72e-13 Morning vs. evening chronotype; LUSC cis rs4891159 0.790 rs1056714 chr18:74149526 A/G cg24786174 chr18:74118243 ZNF516 -0.84 -15.93 -0.66 6.84e-43 Longevity; LUSC cis rs7568458 0.684 rs3731828 chr2:85806266 C/T cg02493740 chr2:85810744 VAMP5 -0.52 -9.07 -0.44 1.07e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7267979 0.727 rs4815431 chr20:25532405 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.8 -16.64 -0.67 1.03e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1729951 0.575 rs361242 chr3:136698330 C/G cg12473912 chr3:136751656 NA 0.38 6.79 0.35 5.14e-11 Neuroticism; LUSC trans rs853679 0.607 rs35072899 chr6:28281541 C/T cg01620082 chr3:125678407 NA -0.82 -7.65 -0.39 2.2e-13 Depression; LUSC cis rs1595825 0.891 rs73061068 chr2:198908439 A/G cg00982548 chr2:198649783 BOLL -0.56 -7.0 -0.36 1.41e-11 Ulcerative colitis; LUSC cis rs9902453 0.780 rs10445384 chr17:28182685 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.89 0.48 2.22e-20 Coffee consumption (cups per day); LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg07507251 chr3:52567010 NT5DC2 0.35 6.81 0.35 4.69e-11 Bipolar disorder; LUSC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg07952391 chr2:88470173 THNSL2 -0.4 -5.65 -0.3 3.45e-8 Response to metformin (IC50); LUSC cis rs7119 0.667 rs4886889 chr15:77902347 T/C cg27398640 chr15:77910606 LINGO1 0.38 8.96 0.44 2.25e-17 Type 2 diabetes; LUSC cis rs7712401 0.601 rs30049 chr5:122306097 G/A cg19077854 chr5:122220652 SNX24 0.43 9.67 0.47 1.14e-19 Mean platelet volume; LUSC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg24562669 chr7:97807699 LMTK2 0.36 6.26 0.32 1.16e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs17824933 1.000 rs17824933 chr11:60760612 C/G cg16817237 chr11:60793675 NA 0.4 6.26 0.32 1.19e-9 Multiple sclerosis; LUSC cis rs11051970 1.000 rs11051970 chr12:32537488 G/T cg24626660 chr12:32551988 NA 0.37 6.26 0.32 1.16e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs8017423 0.967 rs11627429 chr14:90689232 G/A cg14092571 chr14:90743983 NA 0.36 5.82 0.3 1.39e-8 Mortality in heart failure; LUSC cis rs11098499 0.604 rs34278750 chr4:120571136 G/A cg09307838 chr4:120376055 NA 0.7 9.88 0.48 2.23e-20 Corneal astigmatism; LUSC trans rs6561151 0.957 rs1932990 chr13:44460242 C/T cg12856521 chr11:46389249 DGKZ 0.59 7.83 0.39 6.63e-14 Crohn's disease; LUSC cis rs478304 0.903 rs495961 chr11:65540886 C/T cg27068330 chr11:65405492 SIPA1 0.62 9.4 0.46 9.16e-19 Acne (severe); LUSC cis rs7605827 0.930 rs6715487 chr2:15540579 T/C cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg20203395 chr5:56204925 C5orf35 0.5 7.46 0.38 7.4e-13 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23831110 chr14:102785987 ZNF839 -0.44 -6.02 -0.31 4.52e-9 Bipolar disorder and schizophrenia; LUSC cis rs3768617 0.624 rs34105373 chr1:183098387 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.71 0.43 1.39e-16 Fuchs's corneal dystrophy; LUSC cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg14835575 chr10:16859367 RSU1 0.75 9.58 0.46 2.24e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.65 0.43 2.24e-16 Motion sickness; LUSC cis rs400736 0.930 rs226249 chr1:8021778 A/G cg25007680 chr1:8021821 PARK7 0.61 9.54 0.46 3.13e-19 Response to antidepressants and depression; LUSC cis rs9399135 0.967 rs13191501 chr6:135366880 T/C cg22676075 chr6:135203613 NA 0.47 7.27 0.37 2.62e-12 Red blood cell count; LUSC cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg17509989 chr5:176798049 RGS14 -0.66 -9.54 -0.46 3.2e-19 Urate levels in lean individuals; LUSC cis rs2652834 1.000 rs2729784 chr15:63402735 T/C cg05507819 chr15:63340323 TPM1 0.67 8.14 0.41 7.84e-15 HDL cholesterol; LUSC cis rs1559088 0.947 rs10403238 chr19:33552405 A/G cg27124370 chr19:33622961 WDR88 0.51 6.66 0.34 1.14e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs7395662 0.591 rs12807777 chr11:48593754 A/T cg21153622 chr11:89784906 NA -0.4 -6.18 -0.32 1.91e-9 HDL cholesterol; LUSC cis rs10992471 0.603 rs12336884 chr9:95234183 A/C cg14631576 chr9:95140430 CENPP -0.34 -6.17 -0.32 1.97e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs12776158 0.901 rs12414678 chr10:71214669 C/T cg12610070 chr10:71211762 TSPAN15 -0.46 -5.9 -0.31 9.07e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9311676 0.586 rs73085867 chr3:58434791 C/T cg13750441 chr3:58318267 PXK 0.35 6.86 0.35 3.26e-11 Systemic lupus erythematosus; LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg08470875 chr2:26401718 FAM59B 0.73 9.83 0.47 3.35e-20 Gut microbiome composition (summer); LUSC cis rs10876993 0.715 rs2169987 chr12:58012111 G/A cg12615879 chr12:58013172 SLC26A10 -0.31 -6.54 -0.34 2.33e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -6.1 -0.32 2.9e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.78 -0.3 1.75e-8 Bipolar disorder; LUSC trans rs1997103 0.954 rs6593235 chr7:55410986 A/G cg20935933 chr6:143382018 AIG1 0.51 7.38 0.37 1.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6598955 0.585 rs6659822 chr1:26626408 C/A cg00852783 chr1:26633632 UBXN11 -0.5 -5.86 -0.31 1.13e-8 Obesity-related traits; LUSC cis rs12519773 1.000 rs4869412 chr5:92455655 A/G cg18783429 chr5:92414398 NA 0.29 6.38 0.33 6.07e-10 Migraine; LUSC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg08048268 chr3:133502702 NA -0.46 -8.9 -0.44 3.54e-17 Iron status biomarkers; LUSC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg07274523 chr3:49395745 GPX1 0.64 9.89 0.48 2.19e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs7296418 0.636 rs11057261 chr12:123797567 T/C cg00376283 chr12:123451042 ABCB9 0.7 10.74 0.51 2.58e-23 Platelet count; LUSC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs2012796 0.785 rs61986593 chr14:81840659 G/A cg02996355 chr14:81879375 NA 0.58 8.28 0.41 2.93e-15 Night sleep phenotypes; LUSC cis rs4478858 0.660 rs10798844 chr1:31819128 A/G cg00250761 chr1:31883323 NA -0.37 -8.72 -0.43 1.37e-16 Alcohol dependence; LUSC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg03709012 chr19:19516395 GATAD2A 0.87 14.83 0.63 1.38e-38 Tonsillectomy; LUSC cis rs748404 0.676 rs4401024 chr15:43650335 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.29 0.33 1.01e-9 Lung cancer; LUSC cis rs10779751 1.000 rs12032364 chr1:11286872 G/T cg08854313 chr1:11322531 MTOR 0.87 14.68 0.63 5.48e-38 Body mass index; LUSC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg02018176 chr4:1364513 KIAA1530 -0.66 -11.57 -0.53 2.96e-26 Obesity-related traits; LUSC cis rs9814567 0.752 rs4955544 chr3:134332776 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.62 -0.57 4.01e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.69 0.83 1.71e-88 Chronic sinus infection; LUSC cis rs4727027 0.782 rs10245343 chr7:148796333 T/C cg23583168 chr7:148888333 NA -0.8 -12.32 -0.56 5.37e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs4718428 0.662 rs34577323 chr7:66310041 G/C cg18876405 chr7:65276391 NA 0.49 6.62 0.34 1.41e-10 Corneal structure; LUSC cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs422249 0.634 rs174610 chr11:61627833 A/G cg06860612 chr11:61641270 FADS3 0.28 5.92 0.31 7.82e-9 Trans fatty acid levels; LUSC cis rs12464559 0.522 rs10180065 chr2:152619007 A/G cg01189475 chr2:152685088 ARL5A -0.7 -7.46 -0.38 7.32e-13 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.54 -8.24 -0.41 4.05e-15 Lymphocyte counts; LUSC cis rs2795502 0.554 rs1620395 chr10:43341185 G/A cg20628663 chr10:43360327 NA -0.41 -6.71 -0.34 8.47e-11 Blood protein levels; LUSC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg11752832 chr7:134001865 SLC35B4 0.6 9.52 0.46 3.54e-19 Mean platelet volume; LUSC cis rs4919694 1.000 rs76255497 chr10:104651955 T/C cg23093090 chr10:104574429 C10orf26 -0.45 -5.65 -0.3 3.37e-8 Arsenic metabolism; LUSC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg05805236 chr11:65401703 PCNXL3 -0.39 -5.91 -0.31 8.27e-9 Breast cancer; LUSC cis rs1577917 0.958 rs7453105 chr6:86500761 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.86 -0.44 4.78e-17 Response to antipsychotic treatment; LUSC cis rs3892630 0.878 rs1559177 chr19:33210646 A/G cg22980127 chr19:33182716 NUDT19 0.92 12.34 0.56 4.5e-29 Red blood cell traits; LUSC cis rs672059 0.812 rs61418038 chr1:183155717 C/A ch.1.3577855R chr1:183094577 LAMC1 0.59 8.64 0.43 2.36e-16 Hypertriglyceridemia; LUSC cis rs9790314 0.905 rs6441370 chr3:160993754 C/T cg04691961 chr3:161091175 C3orf57 -0.34 -5.9 -0.31 9.1e-9 Morning vs. evening chronotype; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg17683126 chr8:97247889 UQCRB -0.45 -6.01 -0.31 4.73e-9 Neuroticism; LUSC cis rs6076065 0.676 rs1419006 chr20:23336766 C/T cg11657817 chr20:23433608 CST11 0.45 8.37 0.42 1.65e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs7819412 0.540 rs2409726 chr8:11043138 T/C cg21775007 chr8:11205619 TDH -0.47 -6.49 -0.33 3.09e-10 Triglycerides; LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.12 0.36 6.6e-12 Platelet count; LUSC trans rs12310956 0.532 rs10772114 chr12:33853970 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.14 0.36 5.84e-12 Morning vs. evening chronotype; LUSC cis rs17433780 0.504 rs7525985 chr1:89460948 C/T cg09516651 chr1:89888402 LOC400759 0.44 7.7 0.39 1.51e-13 Carotid intima media thickness; LUSC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg22875332 chr1:76189707 ACADM 0.87 14.22 0.61 3.21e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9325144 0.600 rs12297194 chr12:38735803 A/G cg13010199 chr12:38710504 ALG10B -0.46 -7.17 -0.37 4.88e-12 Morning vs. evening chronotype; LUSC cis rs829883 0.872 rs1641637 chr12:98890564 G/A cg25150519 chr12:98850993 NA 0.64 9.84 0.47 3.15e-20 Colorectal adenoma (advanced); LUSC trans rs561341 0.528 rs11650908 chr17:30195425 T/C cg20587970 chr11:113659929 NA 0.66 8.73 0.43 1.28e-16 Hip circumference adjusted for BMI; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg06675538 chr2:114033490 PAX8;LOC440839 -0.31 -5.67 -0.3 3.05e-8 Lymphocyte counts; LUSC cis rs9341808 0.538 rs615585 chr6:80986153 T/C cg08355045 chr6:80787529 NA -0.39 -6.71 -0.34 8.45e-11 Sitting height ratio; LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.16 -0.36 5.18e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg00509249 chr6:109615579 CCDC162 -0.33 -6.05 -0.31 3.86e-9 Reticulocyte fraction of red cells; LUSC cis rs11190604 0.943 rs11190581 chr10:102243387 T/G cg07080220 chr10:102295463 HIF1AN 0.64 8.53 0.42 5.28e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg03806693 chr22:41940476 POLR3H -1.06 -14.96 -0.63 4.34e-39 Vitiligo; LUSC cis rs9815354 0.767 rs73077390 chr3:41860255 T/C cg03022575 chr3:42003672 ULK4 0.83 8.73 0.43 1.28e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.88 -0.81 4.68e-78 Height; LUSC cis rs7597155 0.806 rs11126244 chr2:69974873 C/A cg02498382 chr2:70120550 SNRNP27 -0.24 -5.77 -0.3 1.83e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg17173187 chr15:85201210 NMB -0.44 -7.91 -0.4 3.91e-14 Schizophrenia; LUSC trans rs11700980 0.901 rs11701697 chr21:30127779 T/C cg05609335 chr17:75789393 NA 0.4 6.19 0.32 1.76e-9 QRS complex (12-leadsum); LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg08683831 chr4:1404607 NA 0.37 6.3 0.33 9.43e-10 Obesity-related traits; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg27284194 chr4:1044797 NA 0.34 5.65 0.3 3.38e-8 Obesity-related traits; LUSC cis rs10128251 0.625 rs9424204 chr10:5726376 C/G cg11519256 chr10:5708881 ASB13 0.41 6.23 0.32 1.44e-9 Childhood ear infection; LUSC cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg11584989 chr19:19387371 SF4 0.6 7.12 0.36 6.69e-12 Bipolar disorder; LUSC cis rs2742417 0.603 rs2742398 chr3:45759036 A/G cg04837898 chr3:45731254 SACM1L -0.44 -7.33 -0.37 1.78e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7106204 0.764 rs7933686 chr11:24246790 G/C ch.11.24196551F chr11:24239977 NA 0.93 7.78 0.39 9.19e-14 Response to Homoharringtonine (cytotoxicity); LUSC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg18825119 chr6:163149453 PACRG;PARK2 -0.34 -5.82 -0.3 1.37e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3806843 0.966 rs2337986 chr5:140160622 C/T cg19875535 chr5:140030758 IK 0.5 8.24 0.41 3.98e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg04141948 chr7:1023156 CYP2W1 0.28 5.73 0.3 2.2e-8 Longevity;Endometriosis; LUSC cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.37 5.94 0.31 7.24e-9 IgG glycosylation; LUSC cis rs7568458 0.846 rs6738645 chr2:85783128 T/G cg17127132 chr2:85788382 GGCX 0.45 7.08 0.36 8.69e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4722166 1.000 rs4722166 chr7:22738762 G/T cg05472934 chr7:22766657 IL6 0.42 6.04 0.31 4.17e-9 Lung cancer; LUSC cis rs911119 0.818 rs12625182 chr20:23604023 G/T cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.88 -0.35 3.01e-11 Total body bone mineral density; LUSC cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg05868516 chr6:26286170 HIST1H4H 0.36 5.99 0.31 5.35e-9 Educational attainment; LUSC cis rs7584330 0.504 rs11891426 chr2:238434702 T/G cg16989719 chr2:238392110 NA -0.43 -6.44 -0.33 4.08e-10 Prostate cancer; LUSC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs920590 0.600 rs4921678 chr8:19663449 A/G cg03894339 chr8:19674705 INTS10 0.41 5.87 0.31 1.05e-8 Acute lymphoblastic leukemia (childhood); LUSC trans rs1994135 0.647 rs67243558 chr12:33695383 T/C cg13010199 chr12:38710504 ALG10B 0.53 7.34 0.37 1.65e-12 Resting heart rate; LUSC trans rs1005277 0.579 rs2472182 chr10:38388865 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg05623727 chr3:50126028 RBM5 -0.34 -6.14 -0.32 2.31e-9 Intelligence (multi-trait analysis); LUSC cis rs2295359 0.892 rs72676067 chr1:67658803 G/A cg17031739 chr1:67600172 NA 0.45 6.91 0.35 2.43e-11 Psoriasis; LUSC cis rs2204008 0.805 rs12146846 chr12:37985847 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.94 0.66 5.93e-43 Bladder cancer; LUSC cis rs8114671 0.933 rs6142327 chr20:33793147 T/A cg07148914 chr20:33460835 GGT7 -0.43 -6.41 -0.33 4.82e-10 Height; LUSC cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg13319975 chr6:146136371 FBXO30 0.5 7.48 0.38 6.55e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2806561 0.704 rs663942 chr1:23522476 G/A cg12483005 chr1:23474871 LUZP1 0.45 6.92 0.35 2.28e-11 Height; LUSC cis rs2952156 0.959 rs11653998 chr17:37877447 C/G cg00129232 chr17:37814104 STARD3 -0.48 -7.05 -0.36 1.05e-11 Asthma; LUSC cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg00071950 chr4:10020882 SLC2A9 0.65 11.07 0.52 1.75e-24 Bone mineral density; LUSC cis rs61931739 0.500 rs11053248 chr12:34518011 G/A cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.57e-10 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10921517 chr11:1520881 HCCA2 -0.45 -6.5 -0.34 2.85e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9325144 0.647 rs11169222 chr12:39105210 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.66 -0.47 1.21e-19 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg27170947 chr2:26402098 FAM59B -0.64 -9.37 -0.46 1.11e-18 Gut microbiome composition (summer); LUSC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg11764359 chr7:65958608 NA 0.54 7.7 0.39 1.58e-13 Aortic root size; LUSC trans rs35374984 0.920 rs16930800 chr10:30234268 A/C cg14721108 chr8:142401867 NA -0.65 -5.97 -0.31 6.06e-9 Emphysema distribution in smoking; LUSC cis rs9300255 0.602 rs1716165 chr12:123648881 C/T cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.15 -0.32 2.26e-9 Neutrophil percentage of white cells; LUSC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg13628971 chr7:2884303 GNA12 0.46 6.78 0.35 5.53e-11 Height; LUSC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg11366901 chr6:160182831 ACAT2 0.92 12.15 0.55 2.31e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs7809950 0.530 rs34021916 chr7:106817901 A/G cg23024343 chr7:107201750 COG5 -0.5 -7.2 -0.37 4e-12 Coronary artery disease; LUSC cis rs7954584 0.635 rs7309024 chr12:122338334 C/T cg13699009 chr12:122356056 WDR66 0.48 7.5 0.38 5.99e-13 Mean corpuscular volume; LUSC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg09021430 chr5:549028 NA -0.55 -7.25 -0.37 2.95e-12 Lung disease severity in cystic fibrosis; LUSC cis rs908922 0.651 rs1572534 chr1:152509689 G/A cg20991723 chr1:152506922 NA 0.51 9.51 0.46 3.91e-19 Hair morphology; LUSC cis rs1160297 0.585 rs12713228 chr2:53090032 T/C cg07782112 chr2:53107842 NA 0.41 6.6 0.34 1.64e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs7107174 0.901 rs10899493 chr11:78117534 T/C cg02023728 chr11:77925099 USP35 0.41 6.22 0.32 1.51e-9 Testicular germ cell tumor; LUSC cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg01884057 chr2:25150051 NA 0.46 10.53 0.5 1.38e-22 Body mass index in non-asthmatics; LUSC cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg11984989 chr7:158649758 WDR60 -0.99 -18.18 -0.71 7.89e-52 Height; LUSC cis rs7223966 1.000 rs8067064 chr17:61825984 A/C cg00945038 chr17:61921165 SMARCD2 0.4 6.14 0.32 2.34e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6545883 0.894 rs2694634 chr2:61551435 T/C cg15711740 chr2:61764176 XPO1 0.43 6.67 0.34 1.09e-10 Tuberculosis; LUSC trans rs11098499 0.863 rs1480936 chr4:120462861 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.67 0.34 1.03e-10 Corneal astigmatism; LUSC cis rs7267979 0.808 rs84816 chr20:25459919 G/A cg08601574 chr20:25228251 PYGB 0.4 5.95 0.31 6.73e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.73 0.39 1.26e-13 Bipolar disorder; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg02951883 chr7:2050386 MAD1L1 -0.41 -7.15 -0.36 5.65e-12 Bipolar disorder and schizophrenia; LUSC cis rs813218 0.585 rs9860514 chr3:99917359 G/T cg27384355 chr3:99844353 C3orf26 -0.26 -5.64 -0.3 3.56e-8 Orofacial clefts; LUSC cis rs2439831 0.850 rs558656 chr15:43723514 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.96 11.11 0.52 1.29e-24 Lung cancer in ever smokers; LUSC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg13683864 chr3:40499215 RPL14 -0.93 -15.21 -0.64 4.75e-40 Renal cell carcinoma; LUSC cis rs1372520 0.684 rs2619355 chr4:90748374 A/C cg15133208 chr4:90757351 SNCA -0.53 -8.27 -0.41 3.2e-15 Neuroticism; LUSC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg14668632 chr7:2872130 GNA12 -0.45 -6.57 -0.34 1.96e-10 Height; LUSC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg08499158 chr17:42289980 UBTF 0.52 8.65 0.43 2.16e-16 Total body bone mineral density; LUSC cis rs11690935 0.851 rs7581072 chr2:172859849 C/T cg13550731 chr2:172543902 DYNC1I2 -0.81 -12.9 -0.58 3.53e-31 Schizophrenia; LUSC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19346786 chr7:2764209 NA -0.44 -7.56 -0.38 4.01e-13 Height; LUSC trans rs1015291 0.708 rs1466687 chr12:19996058 A/G cg01501474 chr7:55323552 NA -0.45 -5.97 -0.31 6.09e-9 Diastolic blood pressure; LUSC cis rs7144547 0.803 rs8008602 chr14:81890171 T/A cg02996355 chr14:81879375 NA -0.78 -11.52 -0.53 4.5e-26 Prudent dietary pattern; LUSC cis rs7582720 1.000 rs72936852 chr2:203775475 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.38 0.42 1.49e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs8072100 0.817 rs9905581 chr17:45547185 C/T cg03886242 chr7:26192032 NFE2L3 -0.42 -6.69 -0.34 9.59e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs34421088 0.576 rs2572436 chr8:11099209 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.13 -0.32 2.49e-9 Neuroticism; LUSC cis rs3105593 0.605 rs3131562 chr15:50772479 C/T cg08437265 chr15:50716283 USP8 0.41 5.9 0.31 9.02e-9 QT interval; LUSC cis rs7119 0.604 rs2271396 chr15:77907535 C/G cg27398640 chr15:77910606 LINGO1 0.38 8.91 0.44 3.39e-17 Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21273098 chr6:109762418 SMPD2;PPIL6 -0.42 -6.07 -0.32 3.38e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7267979 0.844 rs6083845 chr20:25388090 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -16.35 -0.67 1.41e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2227930 0.506 rs13080394 chr3:142045889 C/T cg16271453 chr3:142027066 XRN1 -0.55 -9.95 -0.48 1.35e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC trans rs208520 0.955 rs208532 chr6:66961280 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.34 -0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs17270561 0.887 rs9358870 chr6:25719210 T/C cg17691542 chr6:26056736 HIST1H1C 0.71 8.56 0.42 4.1e-16 Iron status biomarkers; LUSC cis rs734999 0.505 rs4648659 chr1:2560903 T/G cg18854424 chr1:2615690 NA -0.49 -9.97 -0.48 1.18e-20 Ulcerative colitis; LUSC trans rs4332037 0.522 rs4721098 chr7:1881527 G/C cg10840412 chr1:235813424 GNG4 -0.46 -6.15 -0.32 2.2e-9 Bipolar disorder; LUSC cis rs5769707 0.681 rs2071902 chr22:50034538 G/C cg20744362 chr22:50050164 C22orf34 0.39 7.31 0.37 1.98e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.876 rs66986937 chr6:86532191 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.79 -0.35 5.14e-11 Response to antipsychotic treatment; LUSC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg15704280 chr7:45808275 SEPT13 1.02 17.3 0.69 2.41e-48 Coronary artery disease; LUSC cis rs36051895 0.559 rs7850228 chr9:5210671 C/G cg02405213 chr9:5042618 JAK2 0.57 8.48 0.42 7.14e-16 Pediatric autoimmune diseases; LUSC cis rs1559088 1.000 rs28840147 chr19:33561976 A/G cg03563238 chr19:33554763 RHPN2 -0.4 -6.23 -0.32 1.43e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg00945038 chr17:61921165 SMARCD2 0.53 9.55 0.46 2.95e-19 Prudent dietary pattern; LUSC cis rs6500395 0.708 rs28449353 chr16:48555134 T/A cg04672837 chr16:48644449 N4BP1 0.38 5.75 0.3 2.04e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg04369109 chr6:150039330 LATS1 -0.52 -7.5 -0.38 5.8e-13 Lung cancer; LUSC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg12463550 chr7:65579703 CRCP -0.49 -7.22 -0.37 3.43e-12 Aortic root size; LUSC cis rs6741892 0.536 rs7590835 chr2:38893950 A/G cg23643435 chr2:38893251 GALM 0.54 6.07 0.32 3.41e-9 5-HTT brain serotonin transporter levels; LUSC cis rs4654899 0.965 rs10753513 chr1:21492168 T/C cg01072550 chr1:21505969 NA 0.53 8.11 0.41 9.91e-15 Superior frontal gyrus grey matter volume; LUSC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg08847533 chr14:75593920 NEK9 0.7 11.32 0.53 2.38e-25 Height; LUSC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg27398817 chr8:82754497 SNX16 -0.64 -8.11 -0.41 9.86e-15 Diastolic blood pressure; LUSC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg19774624 chr17:42201019 HDAC5 0.53 8.37 0.42 1.59e-15 Bone mineral density (hip);Bone mineral density; LUSC cis rs472402 0.623 rs8192130 chr5:6636450 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.4 -5.98 -0.31 5.74e-9 Response to amphetamines; LUSC cis rs11958404 0.860 rs72818111 chr5:157438361 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg10523679 chr1:76189770 ACADM -0.83 -11.37 -0.53 1.59e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.72 0.54 8.55e-27 Prudent dietary pattern; LUSC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg09034736 chr1:150693464 HORMAD1 0.48 7.0 0.36 1.45e-11 Tonsillectomy; LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg11062466 chr8:58055876 NA 0.72 8.66 0.43 2.02e-16 Developmental language disorder (linguistic errors); LUSC cis rs427941 0.659 rs2529373 chr7:101739618 A/G cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4293296 0.525 rs17726476 chr14:54813815 A/C cg02257953 chr14:54816093 NA -0.46 -6.76 -0.35 6.23e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg18512352 chr11:47633146 NA -0.48 -9.65 -0.47 1.34e-19 Subjective well-being; LUSC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg05802129 chr4:122689817 NA -0.37 -6.69 -0.34 9.46e-11 Type 2 diabetes; LUSC cis rs11031096 0.678 rs4606468 chr11:4183643 G/T cg18678763 chr11:4115507 RRM1 -0.43 -6.09 -0.32 3.19e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg18538332 chr22:24372958 LOC391322 0.43 7.72 0.39 1.4e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12893668 0.703 rs4906337 chr14:104040414 C/A cg01849466 chr14:104193079 ZFYVE21 -0.47 -6.49 -0.33 3.08e-10 Reticulocyte count; LUSC cis rs11122272 0.675 rs1416913 chr1:231533206 A/C cg06096015 chr1:231504339 EGLN1 0.58 10.37 0.49 5e-22 Hemoglobin concentration; LUSC cis rs887829 0.570 rs12623271 chr2:234599941 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.3 -0.33 9.47e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg09877947 chr5:131593287 PDLIM4 0.37 5.89 0.31 9.66e-9 Breast cancer;Mosquito bite size; LUSC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg24675658 chr1:53192096 ZYG11B 0.59 8.8 0.43 7.24e-17 Monocyte count; LUSC cis rs1801251 1.000 rs283471 chr2:233656627 G/A cg08000102 chr2:233561755 GIGYF2 0.76 11.84 0.54 3.11e-27 Coronary artery disease; LUSC cis rs62432291 0.681 rs419836 chr6:159659481 C/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC trans rs12579753 0.869 rs12366921 chr12:82223024 G/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.43 -0.33 4.54e-10 Resting heart rate; LUSC cis rs3540 0.512 rs17263706 chr15:91078803 G/T cg10434728 chr15:90938212 IQGAP1 0.44 9.0 0.44 1.69e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg17143192 chr8:8559678 CLDN23 0.66 9.55 0.46 2.97e-19 Obesity-related traits; LUSC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg13390004 chr1:15929781 NA 0.41 6.94 0.36 2.03e-11 Systolic blood pressure; LUSC cis rs1200821 0.529 rs2475206 chr10:37802532 A/G cg25427524 chr10:38739819 LOC399744 0.39 6.41 0.33 4.91e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg03354898 chr7:1950403 MAD1L1 0.43 8.74 0.43 1.13e-16 Bipolar disorder and schizophrenia; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg15242686 chr22:24348715 GSTTP1 -0.44 -6.62 -0.34 1.44e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.65 -0.43 2.26e-16 Body mass index; LUSC cis rs1538970 0.924 rs3790582 chr1:45887288 T/C cg05343316 chr1:45956843 TESK2 0.65 9.03 0.44 1.41e-17 Platelet count; LUSC cis rs13006833 0.668 rs291461 chr2:191181644 T/G cg21644426 chr2:191273491 MFSD6 0.43 6.16 0.32 2.13e-9 Urinary metabolites; LUSC cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg12573674 chr2:1569213 NA 0.55 5.91 0.31 8.23e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 6.02e-10 Menopause (age at onset); LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.11e-9 Menopause (age at onset); LUSC cis rs9300255 0.722 rs28592876 chr12:123866429 G/A cg00376283 chr12:123451042 ABCB9 -0.66 -7.62 -0.39 2.56e-13 Neutrophil percentage of white cells; LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg18404041 chr3:52824283 ITIH1 -0.57 -11.2 -0.52 5.98e-25 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21211418 chr9:34957783 KIAA1045 0.49 7.54 0.38 4.42e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7589342 1.000 rs7589342 chr2:106433478 C/T cg14210321 chr2:106509881 NCK2 -0.54 -8.12 -0.41 9.28e-15 Addiction; LUSC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg12963246 chr6:28129442 ZNF389 0.39 5.96 0.31 6.38e-9 Cardiac Troponin-T levels; LUSC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.47e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg06640241 chr16:89574553 SPG7 0.88 15.84 0.65 1.5e-42 Multiple myeloma (IgH translocation); LUSC cis rs6546550 0.901 rs12613947 chr2:70161342 A/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.22e-12 Prevalent atrial fibrillation; LUSC cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg25817165 chr18:72167213 CNDP2 -0.71 -9.26 -0.45 2.63e-18 Refractive error; LUSC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg06238570 chr21:40685208 BRWD1 0.53 8.1 0.41 1.07e-14 Cognitive function; LUSC cis rs977987 0.800 rs1011121 chr16:75325933 A/G cg03315344 chr16:75512273 CHST6 0.47 8.75 0.43 1.06e-16 Dupuytren's disease; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg07157834 chr1:205819609 PM20D1 0.8 13.7 0.6 3.4e-34 Menarche (age at onset); LUSC cis rs981844 0.712 rs55656103 chr4:154757478 T/C cg14289246 chr4:154710475 SFRP2 0.46 6.26 0.32 1.17e-9 Response to statins (LDL cholesterol change); LUSC cis rs12541635 0.677 rs1496181 chr8:107027141 C/T cg10147462 chr8:107024639 NA 0.67 14.1 0.61 9.6e-36 Age of smoking initiation; LUSC cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.98e-12 Motion sickness; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg18301423 chr5:131593218 PDLIM4 0.35 5.75 0.3 2.06e-8 Blood metabolite levels; LUSC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg13770153 chr20:60521292 NA -0.62 -8.34 -0.42 1.95e-15 Body mass index; LUSC trans rs4332037 0.950 rs11767515 chr7:1941051 C/T cg11693508 chr17:37793320 STARD3 0.65 7.95 0.4 2.93e-14 Bipolar disorder; LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg00814883 chr7:100076585 TSC22D4 -0.66 -8.09 -0.4 1.13e-14 Platelet count; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg13665263 chr7:135662016 MTPN;LUZP6 0.74 7.38 0.37 1.29e-12 Myocardial infarction; LUSC cis rs1160297 0.576 rs74181216 chr2:53093194 G/C cg07782112 chr2:53107842 NA 0.44 7.15 0.36 5.39e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18760251 chr3:169684683 LOC100128164;SEC62 -0.4 -6.09 -0.32 3.03e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04122790 chr1:229762148 URB2;TAF5L 0.36 6.05 0.31 3.94e-9 Triglycerides; LUSC cis rs4285028 0.699 rs6771068 chr3:121478745 A/T cg11130432 chr3:121712080 ILDR1 0.59 8.5 0.42 6.59e-16 Multiple sclerosis; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg20295408 chr7:1910781 MAD1L1 -0.45 -6.52 -0.34 2.59e-10 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.632 rs135872 chr22:50009300 T/C cg05373962 chr22:49881684 NA -0.41 -8.61 -0.43 2.87e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2204008 0.580 rs11174421 chr12:38105138 A/G cg26384229 chr12:38710491 ALG10B 0.81 12.29 0.56 6.62e-29 Bladder cancer; LUSC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg24399712 chr22:39784796 NA -0.59 -9.87 -0.48 2.54e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg20476274 chr7:133979776 SLC35B4 0.83 15.15 0.64 7.59e-40 Mean platelet volume; LUSC cis rs864537 0.646 rs1723016 chr1:167433056 T/C cg22356347 chr1:167427500 CD247 -0.34 -8.19 -0.41 5.49e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs72772090 0.539 rs10515247 chr5:96111726 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.97 -0.36 1.67e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10883723 0.962 rs1056740 chr10:104236552 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.4 -0.38 1.1e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs72960926 0.590 rs72959619 chr6:74995975 A/G cg03266952 chr6:74778945 NA -0.8 -6.78 -0.35 5.51e-11 Metabolite levels (MHPG); LUSC cis rs7614311 0.731 rs73130534 chr3:63859813 A/G cg22134162 chr3:63841271 THOC7 -0.5 -6.06 -0.31 3.72e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs477895 1.000 rs41294396 chr11:64078581 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 6.86 0.35 3.42e-11 Mean platelet volume; LUSC cis rs1348850 1.000 rs1348850 chr2:178418575 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 7.17 0.37 4.74e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9467711 0.591 rs13195279 chr6:25919431 T/A cg08501292 chr6:25962987 TRIM38 0.66 5.69 0.3 2.78e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg26441486 chr22:50317300 CRELD2 0.46 6.79 0.35 5.18e-11 Schizophrenia; LUSC cis rs3806843 1.000 rs4151680 chr5:140186657 A/G cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg07817648 chr10:79422355 NA -0.49 -6.68 -0.34 1.02e-10 Bone mineral density; LUSC cis rs300703 0.542 rs415660 chr2:189972 C/T cg21211680 chr2:198530 NA 0.6 7.53 0.38 4.62e-13 Blood protein levels; LUSC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg07701084 chr6:150067640 NUP43 0.49 7.27 0.37 2.56e-12 Lung cancer; LUSC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg17764715 chr19:33622953 WDR88 0.5 7.5 0.38 5.98e-13 Colorectal cancer; LUSC cis rs3916 1.000 rs2014355 chr12:121175524 A/G cg02419362 chr12:121203948 SPPL3 0.36 5.79 0.3 1.64e-8 Urinary metabolites (H-NMR features); LUSC cis rs6541297 1.000 rs4846839 chr1:230284924 A/G cg20703242 chr1:230279135 GALNT2 0.57 8.88 0.44 4.15e-17 Coronary artery disease; LUSC cis rs701145 0.585 rs447429 chr3:153909946 T/C cg17054900 chr3:154042577 DHX36 0.68 6.76 0.35 5.99e-11 Coronary artery disease; LUSC cis rs2274273 0.967 rs1009978 chr14:55603061 C/G cg04306507 chr14:55594613 LGALS3 0.57 13.32 0.59 9.39e-33 Protein biomarker; LUSC cis rs7647973 0.848 rs4955411 chr3:49145304 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.63 8.75 0.43 1.07e-16 Menarche (age at onset); LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg11645453 chr3:52864694 ITIH4 0.34 7.88 0.4 4.65e-14 Bipolar disorder; LUSC cis rs765787 0.530 rs2413785 chr15:45530381 T/C cg25801113 chr15:45476975 SHF 0.35 7.25 0.37 2.95e-12 Uric acid levels; LUSC cis rs72781680 1.000 rs56068891 chr2:24230633 A/G cg20701182 chr2:24300061 SF3B14 0.75 7.62 0.38 2.73e-13 Lymphocyte counts; LUSC cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.61 -0.57 4.37e-30 Chronic sinus infection; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg27284194 chr4:1044797 NA 0.34 5.74 0.3 2.17e-8 Obesity-related traits; LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg27170947 chr2:26402098 FAM59B -0.72 -11.04 -0.52 2.26e-24 Gut microbiome composition (summer); LUSC cis rs12681287 0.571 rs10097450 chr8:87358677 G/A cg00550725 chr8:87521180 FAM82B -0.42 -5.66 -0.3 3.3e-8 Caudate activity during reward; LUSC cis rs9837602 0.938 rs10511177 chr3:99724873 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.42 6.46 0.33 3.61e-10 Breast cancer; LUSC cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg27129171 chr3:47204927 SETD2 0.69 11.58 0.54 2.66e-26 Colorectal cancer; LUSC cis rs1784581 0.651 rs3016568 chr6:162388158 G/A cg17173639 chr6:162384350 PARK2 -0.68 -12.24 -0.56 1.07e-28 Itch intensity from mosquito bite; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00903010 chr14:23236465 OXA1L -0.43 -6.22 -0.32 1.51e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2204008 0.774 rs11520273 chr12:38354075 A/T cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.28e-9 Bladder cancer; LUSC cis rs2282300 0.637 rs13642 chr11:30432220 A/T cg25418670 chr11:30344373 C11orf46 -0.4 -6.24 -0.32 1.34e-9 Morning vs. evening chronotype; LUSC cis rs7072216 0.763 rs6584201 chr10:100170209 T/C cg26618903 chr10:100175079 PYROXD2 -0.47 -8.86 -0.44 4.94e-17 Metabolite levels; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.03 0.36 1.2e-11 Platelet count; LUSC cis rs763014 0.966 rs15564 chr16:677854 G/T cg03804128 chr16:635623 NA 0.29 5.77 0.3 1.8e-8 Height; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg16325326 chr1:53192061 ZYG11B 0.7 11.4 0.53 1.19e-25 Monocyte count; LUSC cis rs6580649 0.941 rs1635529 chr12:48395102 T/G cg24011408 chr12:48396354 COL2A1 0.56 7.48 0.38 6.66e-13 Lung cancer; LUSC cis rs62408225 1.000 rs11752685 chr6:90966415 A/C cg06866423 chr6:90926672 BACH2 0.4 5.82 0.3 1.37e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg18196295 chr10:418757 DIP2C 0.48 7.98 0.4 2.3e-14 Psychosis in Alzheimer's disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg15089864 chr11:75946986 NA -0.47 -6.15 -0.32 2.24e-9 Hepatitis; LUSC cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg27129171 chr3:47204927 SETD2 -0.71 -11.83 -0.54 3.35e-27 Colorectal cancer; LUSC trans rs2243480 1.000 rs313802 chr7:65516373 A/G cg10756647 chr7:56101905 PSPH 0.85 8.22 0.41 4.44e-15 Diabetic kidney disease; LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg05368731 chr17:41323189 NBR1 0.93 15.69 0.65 5.75e-42 Menopause (age at onset); LUSC cis rs453301 0.624 rs2288671 chr8:8860894 T/C cg18904891 chr8:8559673 CLDN23 0.38 5.69 0.3 2.75e-8 Joint mobility (Beighton score); LUSC cis rs10992471 0.651 rs13296623 chr9:95301627 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.56 -0.34 2.01e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs12701220 0.762 rs7777565 chr7:1003011 C/A cg04102894 chr7:1000210 NA -0.27 -6.37 -0.33 6.4e-10 Bronchopulmonary dysplasia; LUSC cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg01849466 chr14:104193079 ZFYVE21 0.58 9.04 0.44 1.29e-17 Schizophrenia; LUSC cis rs6674970 0.966 rs10788800 chr1:151104950 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.44 -5.91 -0.31 8.34e-9 Childhood ear infection; LUSC cis rs6736093 0.862 rs11684321 chr2:112775750 C/T cg12686935 chr2:112915763 FBLN7 -0.37 -6.03 -0.31 4.26e-9 Coronary artery disease; LUSC cis rs7804356 1.000 rs115447617 chr7:26857751 T/C cg03456212 chr7:26904342 SKAP2 -0.54 -6.31 -0.33 8.7e-10 Type 1 diabetes; LUSC cis rs9287719 0.967 rs2010080 chr2:10736552 A/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg22676075 chr6:135203613 NA 0.59 9.48 0.46 5e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7615952 0.736 rs9866347 chr3:125669925 C/T cg05084668 chr3:125655381 ALG1L -0.9 -12.82 -0.57 7.39e-31 Blood pressure (smoking interaction); LUSC cis rs6502050 0.761 rs11653003 chr17:80058795 G/T cg13939156 chr17:80058883 NA 0.36 7.09 0.36 7.98e-12 Life satisfaction; LUSC cis rs1790761 0.554 rs3758938 chr11:67402362 T/G cg08355456 chr11:67383691 NA -0.38 -6.42 -0.33 4.63e-10 Mean corpuscular volume; LUSC cis rs9650315 0.929 rs7842347 chr8:57172272 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg04317338 chr11:64019027 PLCB3 0.54 6.4 0.33 5.39e-10 Mean platelet volume; LUSC trans rs8072100 0.967 rs3760370 chr17:45695832 C/T cg04995722 chr7:26192034 NFE2L3 0.37 6.17 0.32 2.01e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs7586879 0.639 rs6722022 chr2:25098859 A/G cg04586622 chr2:25135609 ADCY3 0.39 7.95 0.4 2.99e-14 Body mass index; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg00166722 chr3:10149974 C3orf24 0.59 7.9 0.4 4.01e-14 Alzheimer's disease; LUSC cis rs7084921 0.608 rs1853700 chr10:101862694 T/C cg11888571 chr10:102027403 CWF19L1 -0.43 -5.89 -0.31 9.33e-9 Bone mineral density; LUSC trans rs7939886 0.920 rs76934983 chr11:55993334 A/C cg15704280 chr7:45808275 SEPT13 0.9 6.77 0.35 5.92e-11 Myopia (pathological); LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.9 0.31 9.02e-9 Menopause (age at onset); LUSC cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg06552810 chr11:31128660 NA -0.41 -7.37 -0.37 1.33e-12 Red blood cell count; LUSC cis rs868036 0.718 rs7170185 chr15:68117300 T/A cg24579218 chr15:68104479 NA -0.39 -6.78 -0.35 5.61e-11 Restless legs syndrome; LUSC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg06481639 chr22:41940642 POLR3H -0.51 -6.1 -0.32 2.89e-9 Vitiligo; LUSC cis rs4845570 1.000 rs7416415 chr1:151757798 C/T cg07092448 chr1:151763213 TDRKH 1.27 14.77 0.63 2.32e-38 Coronary artery disease; LUSC cis rs9341808 0.718 rs11962614 chr6:80823306 A/T cg08355045 chr6:80787529 NA 0.56 9.85 0.47 2.85e-20 Sitting height ratio; LUSC cis rs4285028 0.898 rs12491991 chr3:121706021 A/C cg11130432 chr3:121712080 ILDR1 0.62 9.96 0.48 1.22e-20 Multiple sclerosis; LUSC trans rs1997103 1.000 rs2331068 chr7:55408220 G/A cg20935933 chr6:143382018 AIG1 0.51 7.47 0.38 6.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg00339695 chr16:24857497 SLC5A11 0.55 7.52 0.38 5.09e-13 Intelligence (multi-trait analysis); LUSC cis rs1733410 0.504 rs11181874 chr12:37912890 C/A cg26384229 chr12:38710491 ALG10B -0.82 -13.55 -0.6 1.28e-33 Morning vs. evening chronotype; LUSC cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg08564027 chr20:61660810 NA 0.92 17.15 0.68 1.02e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs7617480 0.549 rs9879978 chr3:48846600 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.66 9.98 0.48 1.09e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC trans rs2228479 0.850 rs2283565 chr16:89827556 G/T cg24644049 chr4:85504048 CDS1 0.88 7.56 0.38 3.9e-13 Skin colour saturation; LUSC cis rs55665837 1.000 rs10832271 chr11:14466919 C/G cg19336497 chr11:14380999 RRAS2 -0.37 -7.54 -0.38 4.47e-13 Vitamin D levels; LUSC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 1.9e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.78 0.3 1.71e-8 Menopause (age at onset); LUSC cis rs7809950 1.000 rs2237677 chr7:107202502 A/C cg23024343 chr7:107201750 COG5 -0.54 -8.45 -0.42 9.21e-16 Coronary artery disease; LUSC cis rs2180341 0.532 rs6933893 chr6:127707250 A/G cg27446573 chr6:127587934 RNF146 0.62 9.8 0.47 4.28e-20 Breast cancer; LUSC cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg18105134 chr13:113819100 PROZ -0.66 -9.53 -0.46 3.35e-19 Platelet distribution width; LUSC cis rs10992471 0.603 rs9299405 chr9:95284873 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.9 -0.35 2.68e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg06287003 chr12:125626642 AACS -0.38 -6.16 -0.32 2.12e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg03146154 chr1:46216737 IPP -0.52 -7.54 -0.38 4.62e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1790761 0.505 rs7106423 chr11:67314144 A/G cg24690094 chr11:67383802 NA -0.3 -5.71 -0.3 2.5e-8 Mean corpuscular volume; LUSC cis rs1538970 0.816 rs9727262 chr1:45998579 T/G cg06784218 chr1:46089804 CCDC17 0.35 6.07 0.32 3.56e-9 Platelet count; LUSC cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg11584989 chr19:19387371 SF4 0.6 6.86 0.35 3.36e-11 Bipolar disorder; LUSC cis rs17685 0.961 rs41301394 chr7:75612803 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -6.28 -0.33 1.03e-9 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.87 0.35 3.1e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.81 12.93 0.58 2.68e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs17270561 0.887 rs12201170 chr6:25866247 A/G cg16482183 chr6:26056742 HIST1H1C 0.82 10.22 0.49 1.59e-21 Iron status biomarkers; LUSC trans rs4927850 1.000 rs7627868 chr3:195753473 A/T cg16724585 chr3:197361211 NA -0.62 -8.77 -0.43 9.17e-17 Pancreatic cancer; LUSC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg17971929 chr21:40555470 PSMG1 -0.49 -7.09 -0.36 7.86e-12 Menarche (age at onset); LUSC cis rs35000415 0.938 rs12536266 chr7:128611035 G/A cg19972273 chr7:128594194 NA 0.69 6.97 0.36 1.69e-11 Systemic lupus erythematosus; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg06145435 chr7:1022769 CYP2W1 0.29 5.84 0.3 1.26e-8 Longevity;Endometriosis; LUSC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg25124228 chr12:125621409 AACS -0.41 -5.68 -0.3 2.97e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs11190604 1.000 rs2489036 chr10:102319581 A/G cg07080220 chr10:102295463 HIF1AN 0.67 8.62 0.43 2.8e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 13.77 0.6 1.77e-34 Platelet count; LUSC cis rs1790761 0.692 rs638140 chr11:67333858 G/C cg24690094 chr11:67383802 NA 0.42 8.3 0.41 2.7e-15 Mean corpuscular volume; LUSC cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg10523679 chr1:76189770 ACADM -0.52 -7.59 -0.38 3.17e-13 Daytime sleep phenotypes; LUSC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg22800045 chr5:56110881 MAP3K1 0.62 8.77 0.43 9.13e-17 Initial pursuit acceleration; LUSC cis rs10392 0.543 rs57569873 chr20:37558293 T/C cg27552599 chr20:37590471 DHX35 0.45 7.29 0.37 2.32e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs34638657 0.687 rs2303265 chr16:82203705 A/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.58 -0.34 1.78e-10 Lung adenocarcinoma; LUSC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg22800045 chr5:56110881 MAP3K1 0.71 7.37 0.37 1.35e-12 Type 2 diabetes; LUSC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg04865166 chr7:105162814 PUS7 0.52 5.7 0.3 2.63e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7927771 0.839 rs59360790 chr11:47669175 T/C cg20135002 chr11:47629003 NA -0.45 -7.41 -0.38 1.03e-12 Subjective well-being; LUSC cis rs2658782 0.826 rs1975820 chr11:93081815 G/A cg15737290 chr11:93063684 CCDC67 0.69 8.6 0.43 3.12e-16 Pulmonary function decline; LUSC cis rs7113850 0.541 rs7116120 chr11:24235050 A/G ch.11.24196551F chr11:24239977 NA 0.97 9.03 0.44 1.37e-17 Bone fracture in osteoporosis; LUSC cis rs7666738 0.546 rs1863602 chr4:98909304 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.86 0.44 4.88e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs11209185 0.509 rs9436357 chr1:68452488 C/T cg22082780 chr1:68452167 NA 0.48 8.74 0.43 1.19e-16 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2425143 1.000 rs7273815 chr20:34232415 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.22 -0.32 1.52e-9 Blood protein levels; LUSC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg24675056 chr1:15929824 NA 0.42 7.11 0.36 6.91e-12 Systolic blood pressure; LUSC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.78 -0.3 1.73e-8 Alzheimer's disease (late onset); LUSC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg13395646 chr4:1353034 KIAA1530 -0.65 -10.2 -0.49 1.85e-21 Obesity-related traits; LUSC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg26695010 chr11:65641043 EFEMP2 0.45 7.08 0.36 8.47e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg21251018 chr6:28226885 NKAPL 0.33 6.37 0.33 6.26e-10 Cardiac Troponin-T levels; LUSC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg08847533 chr14:75593920 NEK9 -0.66 -10.85 -0.51 1.06e-23 Coronary artery disease; LUSC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg02376097 chr19:46275166 DMPK 0.39 6.79 0.35 5.23e-11 Coronary artery disease; LUSC cis rs8112211 0.598 rs4802351 chr19:38848796 A/G cg14299480 chr19:38876666 GGN -0.44 -6.57 -0.34 1.9e-10 Blood protein levels; LUSC cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg13256891 chr4:100009986 ADH5 -0.44 -6.1 -0.32 2.9e-9 Alcohol dependence; LUSC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg04352962 chr1:209979756 IRF6 0.58 6.38 0.33 5.91e-10 Cleft lip with or without cleft palate; LUSC cis rs7577696 0.568 rs7562653 chr2:32478629 T/C cg02381751 chr2:32503542 YIPF4 0.53 7.1 0.36 7.38e-12 Inflammatory biomarkers; LUSC cis rs1577917 1.000 rs955196 chr6:86729951 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.62 8.89 0.44 3.97e-17 Response to antipsychotic treatment; LUSC cis rs7584330 0.695 rs6709497 chr2:238368925 C/T cg16989719 chr2:238392110 NA -0.38 -6.66 -0.34 1.13e-10 Prostate cancer; LUSC trans rs61931739 0.500 rs11053217 chr12:34470036 A/C cg26384229 chr12:38710491 ALG10B 0.8 13.73 0.6 2.62e-34 Morning vs. evening chronotype; LUSC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg27170947 chr2:26402098 FAM59B 0.62 8.23 0.41 4.38e-15 Gut microbiome composition (summer); LUSC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11890956 chr21:40555474 PSMG1 -0.73 -10.98 -0.52 3.62e-24 Menarche (age at onset); LUSC trans rs80346118 0.925 rs17445063 chr20:47463731 G/T cg16950247 chr11:62911616 SLC22A24 0.49 6.02 0.31 4.52e-9 Diastolic blood pressure; LUSC cis rs2455601 0.786 rs2568068 chr11:8977830 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.44 -7.79 -0.39 8.42e-14 Schizophrenia; LUSC cis rs240764 0.554 rs723742 chr6:101237174 T/A cg09795085 chr6:101329169 ASCC3 0.44 6.27 0.32 1.13e-9 Neuroticism; LUSC cis rs4144743 1.000 rs61312893 chr17:45325023 C/G cg18085866 chr17:45331354 ITGB3 -0.74 -7.89 -0.4 4.35e-14 Body mass index; LUSC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg26597838 chr10:835615 NA 0.98 13.36 0.59 6.59e-33 Eosinophil percentage of granulocytes; LUSC cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg19628046 chr18:33552617 C18orf21 0.51 6.4 0.33 5.27e-10 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs11722228 1.000 rs11722228 chr4:9915741 C/T cg26043149 chr18:55253948 FECH 0.55 8.31 0.41 2.41e-15 Gout;Urate levels;Serum uric acid levels; LUSC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg21951975 chr1:209979733 IRF6 0.59 7.62 0.38 2.7e-13 Cleft lip with or without cleft palate; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg16103275 chr6:290800 DUSP22 0.42 7.15 0.36 5.68e-12 Menopause (age at onset); LUSC cis rs790123 0.933 rs1092556 chr3:122387354 T/G cg17380795 chr3:122379686 NA 0.39 6.43 0.33 4.33e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs10875746 0.903 rs886588 chr12:48477422 A/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs12579753 0.797 rs1922561 chr12:82152640 C/A cg07988820 chr12:82153109 PPFIA2 -0.45 -6.47 -0.33 3.42e-10 Resting heart rate; LUSC cis rs2607426 0.901 rs2607416 chr19:41260831 C/T cg05508168 chr19:41255947 C19orf54;SNRPA 0.62 5.67 0.3 3.08e-8 Blood protein levels; LUSC trans rs3749237 1.000 rs3749237 chr3:49770032 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.51 7.08 0.36 8.61e-12 Resting heart rate; LUSC cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg11502198 chr6:26597334 ABT1 -0.63 -9.55 -0.46 2.87e-19 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg11062466 chr8:58055876 NA 0.47 5.72 0.3 2.39e-8 Developmental language disorder (linguistic errors); LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg01516881 chr6:292596 DUSP22 -0.52 -7.69 -0.39 1.69e-13 Menopause (age at onset); LUSC cis rs12478296 1.000 rs59036157 chr2:243040228 C/A cg06360820 chr2:242988706 NA -0.88 -9.7 -0.47 9.02e-20 Obesity-related traits; LUSC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.61 9.52 0.46 3.49e-19 Total body bone mineral density; LUSC cis rs2289583 0.642 rs11635266 chr15:75386649 T/C cg14664628 chr15:75095509 CSK 0.44 6.28 0.33 1.04e-9 Systemic lupus erythematosus; LUSC cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg08999081 chr20:33150536 PIGU -0.53 -10.47 -0.5 2.33e-22 Glomerular filtration rate (creatinine); LUSC cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.52e-40 Breast cancer; LUSC cis rs12208915 0.848 rs9350786 chr6:79517306 G/T cg05283184 chr6:79620031 NA 0.42 5.68 0.3 2.92e-8 Left atrial antero-posterior diameter; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg17372223 chr3:52568218 NT5DC2 0.38 6.11 0.32 2.73e-9 Electroencephalogram traits; LUSC cis rs11758351 1.000 rs1341759 chr6:26195502 G/A cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.94 0.44 2.77e-17 Height; LUSC cis rs9467773 1.000 rs767471 chr6:26557854 C/T cg05738196 chr6:26577821 NA 0.83 16.17 0.66 7.5e-44 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg03806693 chr22:41940476 POLR3H -0.95 -13.74 -0.6 2.35e-34 Vitiligo; LUSC cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.98 0.55 9.29e-28 Chronic sinus infection; LUSC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg03676636 chr4:99064102 C4orf37 0.36 7.71 0.39 1.48e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.71 0.57 1.77e-30 Cognitive test performance; LUSC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg04362960 chr10:104952993 NT5C2 0.59 9.43 0.46 7.3e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs8072100 0.935 rs12943464 chr17:45690351 A/T cg04995722 chr7:26192034 NFE2L3 0.37 6.15 0.32 2.21e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg25036284 chr2:26402008 FAM59B -0.69 -9.57 -0.46 2.39e-19 Gut microbiome composition (summer); LUSC cis rs3096299 0.606 rs2965960 chr16:89541795 G/A cg02187348 chr16:89574699 SPG7 0.48 6.52 0.34 2.63e-10 Multiple myeloma (IgH translocation); LUSC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.8 0.3 1.56e-8 Personality dimensions; LUSC trans rs9944715 1.000 rs4574015 chr18:43802126 T/C cg01718231 chr17:29326311 RNF135 -0.53 -7.43 -0.38 9.28e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg13390004 chr1:15929781 NA 0.43 7.27 0.37 2.61e-12 Systolic blood pressure; LUSC cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg24692254 chr21:30365293 RNF160 -0.79 -14.42 -0.62 5.61e-37 Dental caries; LUSC trans rs208520 0.690 rs12197578 chr6:66725905 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.83 0.68 1.9e-46 Exhaled nitric oxide output; LUSC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg23711669 chr6:146136114 FBXO30 -0.72 -10.58 -0.5 9.62e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs62103177 0.525 rs4283293 chr18:77759582 A/G cg20368463 chr18:77673604 PQLC1 -0.68 -7.43 -0.38 9.24e-13 Opioid sensitivity; LUSC cis rs7584330 0.518 rs74478860 chr2:238437364 C/G cg14458575 chr2:238380390 NA 0.59 6.88 0.35 3.06e-11 Prostate cancer; LUSC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg27539214 chr16:67997921 SLC12A4 -0.58 -7.67 -0.39 1.9e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs4363385 0.818 rs4845335 chr1:152993955 G/A cg00922841 chr1:152955080 SPRR1A -0.45 -7.72 -0.39 1.37e-13 Inflammatory skin disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17470347 chr1:93646398 CCDC18;TMED5 -0.38 -6.04 -0.31 4.11e-9 Electrocardiographic conduction measures; LUSC cis rs35146811 0.735 rs1727139 chr7:99815367 C/T cg22906224 chr7:99728672 NA -0.47 -6.6 -0.34 1.6e-10 Coronary artery disease; LUSC cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg05985134 chr18:33552581 C18orf21 0.5 6.78 0.35 5.47e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg25703541 chr22:24373054 LOC391322 0.88 14.41 0.62 6.16e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.77 -12.29 -0.56 6.6e-29 Chronic sinus infection; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg06877462 chr1:205807181 PM20D1 0.46 8.22 0.41 4.46e-15 Menarche (age at onset); LUSC cis rs7216064 0.817 rs28609796 chr17:65855104 T/A cg12091567 chr17:66097778 LOC651250 -0.74 -9.25 -0.45 2.79e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7577696 0.785 rs3851310 chr2:32367986 G/T cg02381751 chr2:32503542 YIPF4 -0.43 -5.98 -0.31 5.68e-9 Inflammatory biomarkers; LUSC cis rs3806843 0.735 rs2563306 chr5:140070017 C/T cg19875535 chr5:140030758 IK -0.53 -8.76 -0.43 1.02e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.59 0.78 3.14e-69 Prudent dietary pattern; LUSC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.91 0.31 8.46e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7264396 0.580 rs2064511 chr20:34448810 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.53 6.83 0.35 3.97e-11 Total cholesterol levels; LUSC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg05425664 chr17:57184151 TRIM37 -0.58 -8.82 -0.43 6.32e-17 Intelligence (multi-trait analysis); LUSC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg03517284 chr6:25882590 NA -0.42 -7.12 -0.36 6.82e-12 Intelligence (multi-trait analysis); LUSC cis rs7804356 1.000 rs1982995 chr7:26884135 A/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.08 -0.32 3.28e-9 Type 1 diabetes; LUSC cis rs10876993 0.928 rs774890 chr12:58068388 C/T cg15848620 chr12:58087721 OS9 -0.55 -7.92 -0.4 3.5e-14 Celiac disease or Rheumatoid arthritis; LUSC trans rs34421088 0.560 rs1478898 chr8:11395079 G/A cg11608241 chr8:8085544 FLJ10661 -0.41 -5.99 -0.31 5.55e-9 Neuroticism; LUSC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg25036284 chr2:26402008 FAM59B 0.68 8.68 0.43 1.71e-16 Gut microbiome composition (summer); LUSC cis rs6066835 1.000 rs6095249 chr20:47321045 T/C cg18078177 chr20:47281410 PREX1 0.71 5.96 0.31 6.29e-9 Multiple myeloma; LUSC cis rs1729951 0.575 rs1682333 chr3:136688618 G/A cg12473912 chr3:136751656 NA 0.39 6.83 0.35 4.04e-11 Neuroticism; LUSC cis rs10504229 0.679 rs78941440 chr8:58052095 A/G cg21724239 chr8:58056113 NA 0.53 6.49 0.33 3.17e-10 Developmental language disorder (linguistic errors); LUSC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg06212747 chr3:49208901 KLHDC8B -0.59 -8.35 -0.42 1.87e-15 Menarche (age at onset); LUSC cis rs709400 0.663 rs11624367 chr14:103892818 T/A cg12935359 chr14:103987150 CKB -0.57 -8.68 -0.43 1.73e-16 Body mass index; LUSC cis rs2050392 0.517 rs7096279 chr10:30759608 C/T cg25182066 chr10:30743637 MAP3K8 -0.45 -6.77 -0.35 5.66e-11 Inflammatory bowel disease; LUSC cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg00012203 chr2:219082015 ARPC2 -0.7 -11.41 -0.53 1.08e-25 Colorectal cancer; LUSC cis rs9650315 0.929 rs13260658 chr8:57165144 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.07 0.36 9.07e-12 Height; LUSC cis rs11871801 0.517 rs668799 chr17:40716235 C/T cg16308533 chr17:40838983 CNTNAP1 0.41 5.9 0.31 8.77e-9 Crohn's disease; LUSC cis rs3820928 1.000 rs2163041 chr2:227772480 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.85 -0.39 5.89e-14 Pulmonary function; LUSC cis rs6456156 0.524 rs6932740 chr6:167466439 G/A cg07741184 chr6:167504864 NA 0.39 6.92 0.35 2.27e-11 Primary biliary cholangitis; LUSC cis rs7829975 0.591 rs12677543 chr8:8644274 G/C cg08975724 chr8:8085496 FLJ10661 0.49 7.24 0.37 3.03e-12 Mood instability; LUSC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg00310523 chr12:86230176 RASSF9 0.45 8.32 0.41 2.32e-15 Major depressive disorder; LUSC cis rs2806561 0.734 rs11578046 chr1:23425139 G/A cg12483005 chr1:23474871 LUZP1 0.42 6.14 0.32 2.31e-9 Height; LUSC cis rs634534 0.563 rs470192 chr11:65724291 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.49 9.23 0.45 3.23e-18 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg02475777 chr4:1388615 CRIPAK 0.44 6.81 0.35 4.62e-11 Longevity; LUSC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.72 -0.39 1.35e-13 Height; LUSC cis rs1185460 0.967 rs1786690 chr11:118942067 A/G cg23280166 chr11:118938394 VPS11 0.46 6.59 0.34 1.68e-10 Coronary artery disease; LUSC cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg24112000 chr20:60950667 NA 0.36 6.68 0.34 9.74e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg22800045 chr5:56110881 MAP3K1 0.74 9.71 0.47 8.66e-20 Initial pursuit acceleration; LUSC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4969178 0.965 rs8072632 chr17:76397830 T/C cg20026190 chr17:76395443 PGS1 0.45 8.05 0.4 1.49e-14 HDL cholesterol levels; LUSC cis rs8072100 0.905 rs8077106 chr17:45653291 T/G cg08085267 chr17:45401833 C17orf57 0.59 9.85 0.47 2.96e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10886558 0.502 rs1334439 chr10:121826843 C/T cg02041677 chr10:121771263 NA -0.33 -5.97 -0.31 6.1e-9 Shingles; LUSC cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg09184832 chr6:79620586 NA -0.43 -6.85 -0.35 3.64e-11 Intelligence (multi-trait analysis); LUSC cis rs1003719 0.762 rs4399800 chr21:38489478 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.24 0.52 4.29e-25 Eye color traits; LUSC cis rs4423214 0.592 rs10898193 chr11:71197083 A/G cg05163923 chr11:71159392 DHCR7 0.64 6.9 0.35 2.69e-11 Vitamin D levels; LUSC cis rs10493773 0.775 rs12738010 chr1:86102575 A/C cg17807903 chr1:86174739 ZNHIT6 0.46 11.38 0.53 1.4e-25 Urate levels in overweight individuals; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20284025 chr1:119683198 WARS2 0.82 6.62 0.34 1.4e-10 Cognitive performance; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg14019146 chr3:50243930 SLC38A3 0.36 8.27 0.41 3.11e-15 Body mass index; LUSC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg06636001 chr8:8085503 FLJ10661 0.61 9.66 0.47 1.26e-19 Mood instability; LUSC cis rs79057730 0.639 rs6463933 chr7:793954 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.7 6.88 0.35 2.95e-11 Initial pursuit acceleration; LUSC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.33 0.49 6.71e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg20295408 chr7:1910781 MAD1L1 -0.49 -7.05 -0.36 1.04e-11 Bipolar disorder and schizophrenia; LUSC cis rs17286411 0.750 rs4788575 chr16:71931126 T/G cg03805757 chr16:71968109 PKD1L3 0.42 6.91 0.35 2.46e-11 Blood protein levels; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg14893161 chr1:205819251 PM20D1 0.91 17.89 0.7 1.12e-50 Menarche (age at onset); LUSC cis rs9300255 0.722 rs12298826 chr12:123829028 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 5.9 0.31 8.85e-9 Neutrophil percentage of white cells; LUSC cis rs4589502 0.841 rs56401320 chr15:67140517 C/G cg09911534 chr15:67153556 NA -0.64 -7.22 -0.37 3.52e-12 Lung cancer (smoking interaction); LUSC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs250677 0.687 rs168750 chr5:148446756 A/G cg18129178 chr5:148520854 ABLIM3 -0.69 -10.62 -0.5 6.72e-23 Breast cancer; LUSC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg03233332 chr7:66118400 NA -0.41 -6.07 -0.31 3.56e-9 Aortic root size; LUSC cis rs6977660 0.943 rs10277755 chr7:19826843 C/A cg05791153 chr7:19748676 TWISTNB 0.52 5.81 0.3 1.47e-8 Thyroid stimulating hormone; LUSC cis rs225245 1.000 rs225245 chr17:33946107 A/G cg05299278 chr17:33885742 SLFN14 0.28 6.0 0.31 5.04e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs561341 0.505 rs548298 chr17:30297494 C/A cg20587970 chr11:113659929 NA -1.11 -15.3 -0.64 1.99e-40 Hip circumference adjusted for BMI; LUSC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC trans rs2587949 0.615 rs2874813 chr3:4208715 T/G cg15139668 chr4:4577005 NA -0.41 -6.08 -0.32 3.23e-9 Periodontitis (DPAL); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21792150 chr3:101567884 NFKBIZ 0.46 6.18 0.32 1.91e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2073300 0.609 rs77908916 chr20:23405626 C/G cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4073416 0.518 rs2210805 chr14:65892724 C/G cg03016385 chr14:66212404 NA -0.4 -6.18 -0.32 1.87e-9 N-glycan levels; LUSC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg08219700 chr8:58056026 NA 0.47 5.94 0.31 7.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs865483 0.860 rs12603185 chr17:35868304 T/C cg06716730 chr17:35851459 DUSP14 0.28 6.31 0.33 8.79e-10 Monocyte count; LUSC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11644478 chr21:40555479 PSMG1 -0.74 -13.22 -0.59 2.21e-32 Cognitive function; LUSC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg17911788 chr17:44343683 NA -0.32 -6.07 -0.32 3.55e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg24399712 chr22:39784796 NA -0.61 -10.86 -0.51 1.01e-23 Intelligence (multi-trait analysis); LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg00945038 chr17:61921165 SMARCD2 0.52 8.8 0.43 7.26e-17 Prudent dietary pattern; LUSC cis rs3008870 0.727 rs4582760 chr1:67464394 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.74 -12.09 -0.55 3.66e-28 Lymphocyte percentage of white cells; LUSC cis rs72634258 0.945 rs35675666 chr1:8021973 G/T cg00042356 chr1:8021962 PARK7 0.85 10.24 0.49 1.44e-21 Inflammatory bowel disease; LUSC cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg27446573 chr6:127587934 RNF146 0.92 15.21 0.64 4.64e-40 Breast cancer; LUSC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.1 -0.36 7.32e-12 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg18876405 chr7:65276391 NA -0.68 -12.22 -0.56 1.26e-28 Aortic root size; LUSC cis rs11030122 0.702 rs10500590 chr11:3964724 T/C cg08557956 chr11:4115526 RRM1 -0.45 -5.69 -0.3 2.74e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs7582180 0.764 rs11689439 chr2:100925399 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg27094323 chr7:1216898 NA -0.37 -6.42 -0.33 4.79e-10 Longevity;Endometriosis; LUSC cis rs1322512 0.883 rs2758814 chr6:152966367 C/T cg03415253 chr6:152958462 SYNE1 -0.38 -5.68 -0.3 2.95e-8 Tonometry; LUSC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs73001065 0.901 rs73004962 chr19:19713069 A/T cg03709012 chr19:19516395 GATAD2A 0.89 7.16 0.36 5.2e-12 LDL cholesterol; LUSC cis rs4604732 0.631 rs12091081 chr1:247623064 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.48 7.04 0.36 1.08e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6961069 0.550 rs62461695 chr7:80258208 T/G cg04458919 chr7:80252533 CD36 0.4 7.01 0.36 1.31e-11 Platelet count; LUSC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg22963979 chr7:1858916 MAD1L1 0.56 8.56 0.42 4.08e-16 Bipolar disorder and schizophrenia; LUSC cis rs4363385 0.693 rs4845497 chr1:152904162 T/C cg00922841 chr1:152955080 SPRR1A -0.4 -6.55 -0.34 2.16e-10 Inflammatory skin disease; LUSC cis rs7937890 0.904 rs11023169 chr11:14290985 C/A cg22961513 chr11:14280813 SPON1 0.34 5.73 0.3 2.28e-8 Mitochondrial DNA levels; LUSC cis rs826838 0.872 rs826878 chr12:39088837 A/T cg26384229 chr12:38710491 ALG10B -0.78 -13.45 -0.59 2.96e-33 Heart rate; LUSC trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg15704280 chr7:45808275 SEPT13 0.93 13.42 0.59 3.7e-33 Coronary artery disease; LUSC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg18681998 chr4:17616180 MED28 -0.84 -14.98 -0.63 3.73e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.94 -0.31 7.06e-9 Platelet count; LUSC cis rs838147 0.507 rs1704773 chr19:49209566 A/G cg21064579 chr19:49206444 FUT2 0.46 8.66 0.43 2.07e-16 Dietary macronutrient intake; LUSC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.01e-10 Blood pressure (smoking interaction); LUSC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg23649088 chr2:200775458 C2orf69 0.78 14.27 0.62 2.08e-36 Osteoporosis; LUSC cis rs2732480 0.500 rs1552550 chr12:48643351 C/A cg04545296 chr12:48745243 ZNF641 0.33 6.04 0.31 4.14e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg26384229 chr12:38710491 ALG10B 0.96 17.69 0.7 7.15e-50 Heart rate; LUSC trans rs7618314 0.571 rs882892 chr3:108498405 A/T cg05749855 chr16:89472771 ANKRD11 0.59 6.0 0.31 5.2e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg25767906 chr1:53392781 SCP2 -0.49 -8.69 -0.43 1.63e-16 Monocyte count; LUSC cis rs981844 1.000 rs2263434 chr4:154658312 A/G cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg05585544 chr11:47624801 NA -0.43 -7.51 -0.38 5.37e-13 Subjective well-being; LUSC cis rs7246657 0.943 rs10420754 chr19:37959372 C/G cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg05623727 chr3:50126028 RBM5 -0.36 -6.71 -0.34 8.19e-11 Body mass index; LUSC cis rs10792830 0.771 rs629343 chr11:85811138 C/T cg07180834 chr11:85838833 NA 0.31 6.01 0.31 4.84e-9 Psychosis and Alzheimer's disease; LUSC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs4285028 0.656 rs2141487 chr3:121482765 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.9 12.46 0.56 1.54e-29 Multiple sclerosis; LUSC trans rs7618501 0.602 rs2624816 chr3:50117312 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.73 -0.47 7.36e-20 Intelligence (multi-trait analysis); LUSC cis rs55871839 0.684 rs6988143 chr8:59810572 C/T cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs2762353 0.935 rs11754288 chr6:25776949 G/A cg03264133 chr6:25882463 NA 0.4 6.81 0.35 4.45e-11 Blood metabolite levels; LUSC cis rs2502731 0.539 rs3003610 chr9:130985525 G/A cg09976142 chr9:130955436 CIZ1 0.44 7.49 0.38 6.2e-13 Attention deficit hyperactivity disorder; LUSC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg15704280 chr7:45808275 SEPT13 -1.13 -24.87 -0.81 5.2e-78 Height; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs7267979 0.527 rs6076369 chr20:25576783 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.67 -0.57 2.71e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6163 0.540 rs11191385 chr10:104513049 G/T cg05855489 chr10:104503620 C10orf26 0.74 11.43 0.53 9.28e-26 Waist circumference;Hip circumference; LUSC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg03526776 chr6:41159608 TREML2 0.33 6.12 0.32 2.67e-9 Alzheimer's disease (late onset); LUSC cis rs4654899 0.865 rs12406144 chr1:21347228 A/C cg01072550 chr1:21505969 NA -0.54 -8.03 -0.4 1.67e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6840360 0.593 rs2175409 chr4:152701656 A/G cg22705602 chr4:152727874 NA -0.38 -8.23 -0.41 4.18e-15 Intelligence (multi-trait analysis); LUSC trans rs11722228 0.549 rs41268389 chr4:10099277 G/A cg26043149 chr18:55253948 FECH 0.98 14.93 0.63 5.84e-39 Gout;Urate levels;Serum uric acid levels; LUSC cis rs8078723 0.690 rs3785549 chr17:38149724 T/C cg17467752 chr17:38218738 THRA -0.7 -11.27 -0.52 3.54e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs208515 0.525 rs9453538 chr6:66668508 G/A cg07460842 chr6:66804631 NA 1.04 14.11 0.61 9.12e-36 Exhaled nitric oxide levels; LUSC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg05802129 chr4:122689817 NA -0.35 -6.13 -0.32 2.42e-9 Type 2 diabetes; LUSC cis rs62400317 1.000 rs62400317 chr6:45284923 C/T cg20913747 chr6:44695427 NA -0.46 -7.48 -0.38 6.5e-13 Total body bone mineral density; LUSC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg03289416 chr15:75166202 SCAMP2 0.45 6.83 0.35 4.11e-11 Breast cancer; LUSC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.33 -0.37 1.74e-12 Aortic root size; LUSC cis rs3820928 0.874 rs10207404 chr2:227794420 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.76 -0.39 1.07e-13 Pulmonary function; LUSC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.42 6.06 0.31 3.69e-9 Height; LUSC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.63 -0.34 1.32e-10 Aortic root size; LUSC trans rs2898290 0.593 rs1600252 chr8:11345644 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.35 -0.33 7.06e-10 Systolic blood pressure; LUSC cis rs2677744 1.000 rs4773 chr15:91463842 G/A cg00526711 chr15:91477898 UNC45A 0.3 6.06 0.31 3.6e-9 Attention deficit hyperactivity disorder; LUSC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg12463550 chr7:65579703 CRCP 0.51 7.46 0.38 7.34e-13 Aortic root size; LUSC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg13206674 chr6:150067644 NUP43 0.63 10.32 0.49 7.59e-22 Lung cancer; LUSC cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg17173187 chr15:85201210 NMB -0.47 -9.06 -0.44 1.14e-17 Schizophrenia; LUSC trans rs7829975 0.742 rs1533058 chr8:8685190 A/G cg27411982 chr8:10470053 RP1L1 0.4 6.13 0.32 2.45e-9 Mood instability; LUSC cis rs8017423 0.967 rs4904662 chr14:90729427 G/A cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs6500395 0.962 rs9927888 chr16:48557764 A/T cg04672837 chr16:48644449 N4BP1 0.45 6.6 0.34 1.61e-10 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs17685 0.712 rs60232511 chr7:75800082 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.23 0.72 5.2e-56 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg07741184 chr6:167504864 NA -0.42 -7.66 -0.39 2.06e-13 Crohn's disease; LUSC cis rs11048434 0.761 rs1805723 chr12:9142297 T/C cg23795048 chr12:9217529 LOC144571 0.34 5.86 0.31 1.1e-8 Sjögren's syndrome; LUSC cis rs3862435 0.518 rs2601189 chr15:90929874 G/A cg22089800 chr15:90895588 ZNF774 0.56 5.96 0.31 6.33e-9 Response to exercise (triglyceride level interaction); LUSC cis rs75229567 0.618 rs78294090 chr12:70209959 G/T cg10114359 chr12:70132523 RAB3IP 1.29 11.72 0.54 8.07e-27 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs73200209 0.626 rs56178625 chr12:116578048 A/G cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg18876405 chr7:65276391 NA -0.55 -8.76 -0.43 9.78e-17 Aortic root size; LUSC cis rs9815354 0.716 rs76313799 chr3:41931751 A/C cg03022575 chr3:42003672 ULK4 0.82 8.55 0.42 4.49e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs174479 0.677 rs174463 chr11:61657838 G/A cg01500311 chr11:61656094 FADS3 0.4 6.96 0.36 1.8e-11 Sphingolipid levels; LUSC cis rs2073300 0.609 rs3746733 chr20:23349749 C/T cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg05234568 chr11:5960015 NA -0.55 -7.78 -0.39 9.12e-14 DNA methylation (variation); LUSC cis rs28374715 0.662 rs11852419 chr15:41456374 A/T cg18705301 chr15:41695430 NDUFAF1 0.82 15.09 0.64 1.3e-39 Ulcerative colitis; LUSC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.63 8.0 0.4 2.05e-14 Age-related macular degeneration (geographic atrophy); LUSC trans rs877282 0.945 rs35342920 chr10:790484 T/C cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs6977660 0.714 rs12700077 chr7:19791607 A/G cg07541023 chr7:19748670 TWISTNB -0.66 -7.34 -0.37 1.68e-12 Thyroid stimulating hormone; LUSC cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg16797656 chr11:68205561 LRP5 0.36 6.13 0.32 2.49e-9 Total body bone mineral density; LUSC cis rs6714710 0.603 rs78006955 chr2:98455510 G/C cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs12973672 1.000 rs12973672 chr19:35767866 A/G cg12095397 chr19:35769544 USF2 0.45 7.04 0.36 1.13e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6541297 1.000 rs6658942 chr1:230287517 A/C cg20703242 chr1:230279135 GALNT2 0.58 9.05 0.44 1.21e-17 Coronary artery disease; LUSC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg00701064 chr4:6280414 WFS1 0.57 13.67 0.6 4.48e-34 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg13732083 chr21:47605072 C21orf56 -0.47 -6.98 -0.36 1.57e-11 Testicular germ cell tumor; LUSC cis rs727505 0.754 rs55723877 chr7:124780899 T/A cg23710748 chr7:124431027 NA -0.4 -7.02 -0.36 1.24e-11 Lewy body disease; LUSC cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg04117972 chr1:227635322 NA 0.61 6.88 0.35 2.9e-11 Major depressive disorder; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg14092988 chr3:52407081 DNAH1 0.32 6.19 0.32 1.78e-9 Bipolar disorder; LUSC cis rs66887589 1.000 rs66887589 chr4:120509279 T/C cg09307838 chr4:120376055 NA -0.48 -7.18 -0.37 4.45e-12 Diastolic blood pressure; LUSC cis rs9905704 0.647 rs6503892 chr17:57067086 G/A cg05425664 chr17:57184151 TRIM37 -0.52 -7.67 -0.39 1.92e-13 Testicular germ cell tumor; LUSC cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.67 11.66 0.54 1.42e-26 Personality dimensions; LUSC cis rs6429082 0.633 rs1416473 chr1:235563259 C/T cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.82 -0.35 4.37e-11 Adiposity; LUSC cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg24812749 chr6:127587940 RNF146 0.91 13.55 0.6 1.23e-33 Breast cancer; LUSC cis rs727505 0.954 rs66691367 chr7:124654217 G/T cg23710748 chr7:124431027 NA -0.38 -6.58 -0.34 1.79e-10 Lewy body disease; LUSC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.48 0.33 3.32e-10 Lung cancer; LUSC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg23985595 chr17:80112537 CCDC57 0.3 5.75 0.3 2.06e-8 Life satisfaction; LUSC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg13114125 chr14:105738426 BRF1 -0.93 -16.05 -0.66 2.2e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.78 -0.3 1.7e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg03388025 chr16:89894329 SPIRE2 0.35 7.44 0.38 8.86e-13 Vitiligo; LUSC cis rs1559088 1.000 rs2161225 chr19:33551899 C/T cg17764715 chr19:33622953 WDR88 0.58 7.82 0.39 7.14e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6967385 0.934 rs10259100 chr7:12384664 G/A cg06484146 chr7:12443880 VWDE 0.39 5.71 0.3 2.5e-8 Response to taxane treatment (placlitaxel); LUSC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg10128416 chr1:75198403 TYW3;CRYZ -0.52 -7.54 -0.38 4.6e-13 Resistin levels; LUSC cis rs721399 0.539 rs10103029 chr8:18267338 A/G cg18736775 chr8:18248649 NAT2 -0.6 -7.09 -0.36 7.9e-12 Blood metabolite levels; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.52e-10 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg03676636 chr4:99064102 C4orf37 0.39 8.0 0.4 2.06e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs71403859 0.502 rs12927456 chr16:71505706 A/G cg08717414 chr16:71523259 ZNF19 -0.75 -8.71 -0.43 1.46e-16 Post bronchodilator FEV1; LUSC cis rs2073300 1.000 rs6137966 chr20:23444359 A/T cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg18132916 chr6:79620363 NA -0.38 -5.73 -0.3 2.19e-8 Intelligence (multi-trait analysis); LUSC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg05234568 chr11:5960015 NA 0.61 8.96 0.44 2.35e-17 DNA methylation (variation); LUSC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.79 8.23 0.41 4.39e-15 Initial pursuit acceleration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04433306 chr7:129592730 UBE2H -0.51 -6.02 -0.31 4.55e-9 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.706 rs12947506 chr17:37707592 A/G cg07936489 chr17:37558343 FBXL20 -0.83 -10.53 -0.5 1.44e-22 Glomerular filtration rate (creatinine); LUSC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.72 0.34 8.06e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7481584 0.624 rs413368 chr11:3047646 C/G cg05729581 chr11:3078854 CARS 0.4 5.85 0.3 1.16e-8 Calcium levels; LUSC cis rs7666738 0.515 rs13118898 chr4:98792893 T/A cg03676636 chr4:99064102 C4orf37 0.3 5.99 0.31 5.55e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1371867 0.846 rs1788197 chr8:101290928 T/C cg06002616 chr8:101225028 SPAG1 -0.41 -6.84 -0.35 3.71e-11 Atrioventricular conduction; LUSC cis rs7511006 0.798 rs11703673 chr22:50652427 A/G cg16473166 chr22:50639996 SELO -0.53 -7.02 -0.36 1.27e-11 Obesity-related traits; LUSC cis rs12541635 0.966 rs55762012 chr8:107033218 T/C cg10147462 chr8:107024639 NA 0.55 9.83 0.47 3.44e-20 Age of smoking initiation; LUSC cis rs10905065 0.965 rs2890365 chr10:5773876 C/A cg11519256 chr10:5708881 ASB13 -0.4 -5.83 -0.3 1.28e-8 Menopause (age at onset); LUSC cis rs7903847 0.642 rs10882913 chr10:99141845 C/T cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.57e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg05535760 chr7:792225 HEATR2 -0.82 -7.86 -0.4 5.38e-14 Cerebrospinal P-tau181p levels; LUSC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg09877947 chr5:131593287 PDLIM4 0.45 7.31 0.37 2.03e-12 Breast cancer; LUSC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg00933542 chr6:150070202 PCMT1 0.33 6.92 0.35 2.35e-11 Lung cancer; LUSC cis rs2688608 0.653 rs12775558 chr10:75570868 G/A cg17411546 chr10:75410026 SYNPO2L -0.55 -8.31 -0.41 2.51e-15 Inflammatory bowel disease; LUSC cis rs6582630 0.599 rs8189525 chr12:38424982 A/C cg13010199 chr12:38710504 ALG10B 0.43 6.48 0.33 3.29e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg07701084 chr6:150067640 NUP43 0.57 8.85 0.44 5.05e-17 Lung cancer; LUSC cis rs6733011 0.508 rs13004700 chr2:99527568 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.67 -0.3 3.14e-8 Bipolar disorder; LUSC cis rs61931739 0.929 rs1825358 chr12:34011895 C/T cg06521331 chr12:34319734 NA 0.4 6.56 0.34 1.99e-10 Morning vs. evening chronotype; LUSC cis rs240764 0.782 rs12216199 chr6:101152723 C/A cg09795085 chr6:101329169 ASCC3 -0.42 -6.15 -0.32 2.18e-9 Neuroticism; LUSC cis rs8027181 0.839 rs2304597 chr15:73052431 A/G cg25632853 chr15:73088954 NA 0.32 6.42 0.33 4.77e-10 Triglyceride levels; LUSC cis rs11711311 0.955 rs7617313 chr3:113391740 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.32 0.33 8.24e-10 IgG glycosylation; LUSC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg05861140 chr6:150128134 PCMT1 -0.4 -6.25 -0.32 1.25e-9 Lung cancer; LUSC cis rs9527 0.590 rs7898770 chr10:104756636 A/G cg04362960 chr10:104952993 NT5C2 -0.59 -9.16 -0.45 5.52e-18 Arsenic metabolism; LUSC trans rs853679 0.517 rs9357063 chr6:28060005 G/A cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.31e-9 Depression; LUSC cis rs12410462 0.581 rs4329477 chr1:227552494 A/G cg04117972 chr1:227635322 NA -0.57 -6.79 -0.35 5.29e-11 Major depressive disorder; LUSC cis rs7904368 0.754 rs7091240 chr10:16855683 G/A cg23933602 chr10:16859644 RSU1 0.54 6.51 0.34 2.83e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs259282 0.628 rs2287669 chr19:33110204 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.65 9.69 0.47 1e-19 Schizophrenia; LUSC cis rs9611519 0.894 rs9623320 chr22:41478482 G/A cg03806693 chr22:41940476 POLR3H -0.56 -7.49 -0.38 6.05e-13 Neuroticism; LUSC cis rs9303401 0.580 rs2013166 chr17:56637630 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC trans rs208520 0.690 rs2144081 chr6:66824972 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.48 -0.69 4.87e-49 Exhaled nitric oxide output; LUSC cis rs11098499 0.863 rs3822192 chr4:120445720 A/C cg09307838 chr4:120376055 NA 0.74 10.36 0.49 5.54e-22 Corneal astigmatism; LUSC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.89 14.47 0.62 3.69e-37 IgG glycosylation; LUSC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg00677455 chr12:58241039 CTDSP2 0.61 8.47 0.42 7.68e-16 Multiple sclerosis; LUSC cis rs8025790 0.508 rs12902812 chr15:67909279 C/T cg05925327 chr15:68127851 NA -0.4 -5.97 -0.31 6.11e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs2404602 0.622 rs11637296 chr15:77207885 C/A cg23625390 chr15:77176239 SCAPER -0.67 -10.12 -0.48 3.55e-21 Blood metabolite levels; LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg01879757 chr17:41196368 BRCA1 -0.45 -6.83 -0.35 3.97e-11 Menopause (age at onset); LUSC cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.88 0.31 9.9e-9 Breast cancer; LUSC trans rs45509595 0.841 rs370155 chr6:27782031 T/G cg06606381 chr12:133084897 FBRSL1 -0.69 -7.0 -0.36 1.38e-11 Breast cancer; LUSC cis rs4423214 0.592 rs7130829 chr11:71237702 A/T cg05163923 chr11:71159392 DHCR7 -0.66 -6.87 -0.35 3.23e-11 Vitamin D levels; LUSC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4295623 0.559 rs4841600 chr8:11688148 T/C cg00262122 chr8:11665843 FDFT1 0.52 7.9 0.4 4.17e-14 Morning vs. evening chronotype; LUSC trans rs747782 0.528 rs16905753 chr11:48285906 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.72 0.35 7.98e-11 Intraocular pressure; LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.37 0.53 1.56e-25 Prudent dietary pattern; LUSC cis rs7923609 1.000 rs2393969 chr10:65140440 A/C cg01631684 chr10:65280961 REEP3 -0.38 -5.9 -0.31 9.15e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9296092 0.538 rs80012910 chr6:33519542 G/A cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7267979 0.586 rs6037057 chr20:25182089 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.71 0.57 1.82e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4964805 0.641 rs10861094 chr12:104159716 C/A cg02344784 chr12:104178138 NT5DC3 0.37 5.96 0.31 6.51e-9 Attention deficit hyperactivity disorder; LUSC cis rs597583 1.000 rs597583 chr11:117421799 C/G cg27161313 chr11:117392002 DSCAML1 -0.43 -7.47 -0.38 7.25e-13 Putamen volume; LUSC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.75 0.35 6.4e-11 Tonsillectomy; LUSC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.4 -0.42 1.26e-15 Mean platelet volume; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.58 -9.09 -0.45 9.29e-18 Lymphocyte counts; LUSC trans rs2363709 0.881 rs1994609 chr3:67386701 T/C cg23062198 chr2:14774063 FAM84A 0.57 6.14 0.32 2.31e-9 IgE levels; LUSC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg11812906 chr14:75593930 NEK9 -0.53 -8.67 -0.43 1.94e-16 Coronary artery disease; LUSC cis rs4595586 0.545 rs1839402 chr12:39371615 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.6e-11 Morning vs. evening chronotype; LUSC cis rs8141529 0.764 rs5752812 chr22:29225603 T/A cg15103426 chr22:29168792 CCDC117 0.59 8.3 0.41 2.69e-15 Lymphocyte counts; LUSC cis rs72781680 0.566 rs55987381 chr2:23900938 T/C cg08917208 chr2:24149416 ATAD2B 0.74 8.51 0.42 5.8e-16 Lymphocyte counts; LUSC cis rs2154427 1.000 rs2833962 chr21:34174289 A/G cg21871883 chr21:34145043 C21orf49;C21orf66 0.62 5.89 0.31 9.41e-9 Bilirubin levels; LUSC cis rs9517320 0.534 rs4772088 chr13:99138270 T/G cg07423050 chr13:99094983 FARP1 -0.56 -10.54 -0.5 1.3e-22 Longevity; LUSC cis rs847577 0.630 rs3801294 chr7:97822210 G/A cg24562669 chr7:97807699 LMTK2 0.48 8.56 0.42 4.18e-16 Breast cancer; LUSC cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.5 0.34 2.87e-10 Lung cancer in ever smokers; LUSC cis rs977987 0.835 rs3851734 chr16:75371920 T/C cg04384234 chr16:75411784 CFDP1 -0.4 -6.57 -0.34 1.94e-10 Dupuytren's disease; LUSC cis rs2455601 0.882 rs11042105 chr11:8894510 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -8.4 -0.42 1.28e-15 Schizophrenia; LUSC cis rs6599077 0.950 rs9809788 chr3:40103734 T/C cg13683864 chr3:40499215 RPL14 -0.61 -7.6 -0.38 3.09e-13 Sleep-related phenotypes; LUSC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg22823121 chr1:150693482 HORMAD1 0.47 6.84 0.35 3.78e-11 Melanoma; LUSC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.28e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg23711669 chr6:146136114 FBXO30 -0.82 -14.57 -0.62 1.45e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg11663144 chr21:46675770 NA -0.41 -7.21 -0.37 3.86e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs7940866 0.903 rs10791112 chr11:130870215 A/C cg12179176 chr11:130786555 SNX19 -0.58 -8.9 -0.44 3.7e-17 Schizophrenia; LUSC cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg22709100 chr7:91322751 NA 0.38 5.65 0.3 3.48e-8 Breast cancer; LUSC cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg24642439 chr20:33292090 TP53INP2 0.48 7.16 0.36 5.1e-12 Glomerular filtration rate (creatinine); LUSC cis rs6847149 1.000 rs6852679 chr4:110804414 T/C cg07850274 chr4:110748770 RRH 0.6 7.71 0.39 1.45e-13 Exercise treadmill test traits; LUSC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg18850127 chr7:39170497 POU6F2 0.64 10.51 0.5 1.6e-22 IgG glycosylation; LUSC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.97 0.51 4.04e-24 Monocyte percentage of white cells; LUSC cis rs2760061 0.599 rs644794 chr1:228148670 T/C cg02753203 chr1:228287806 NA -0.65 -11.14 -0.52 1.02e-24 Diastolic blood pressure; LUSC cis rs9311676 0.656 rs62258081 chr3:58367705 A/C cg26110898 chr3:58419937 PDHB 0.43 7.15 0.36 5.67e-12 Systemic lupus erythematosus; LUSC cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.11e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg12463550 chr7:65579703 CRCP -0.57 -8.46 -0.42 8.37e-16 Aortic root size; LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs500891 0.953 rs2145324 chr6:84194408 C/T cg08257003 chr6:84140564 ME1 -0.35 -7.31 -0.37 1.95e-12 Platelet-derived growth factor BB levels; LUSC cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.18 -0.37 4.56e-12 Bipolar disorder; LUSC cis rs41271473 0.500 rs10916366 chr1:228894575 T/C cg16512390 chr1:228756714 NA 0.46 6.34 0.33 7.31e-10 Chronic lymphocytic leukemia; LUSC trans rs9503598 0.636 rs6596975 chr6:3465925 G/A cg05722439 chr19:14072965 RFX1 -0.31 -6.04 -0.31 4.06e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs2933343 0.672 rs1872545 chr3:128645039 G/C cg11901034 chr3:128598214 ACAD9 -0.41 -6.47 -0.33 3.39e-10 IgG glycosylation; LUSC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg17948913 chr5:572064 NA 0.36 6.08 0.32 3.32e-9 Obesity-related traits; LUSC trans rs11098499 0.779 rs80242894 chr4:120375752 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs6121246 0.559 rs6121243 chr20:30415094 C/G cg18721089 chr20:30220636 NA -0.31 -5.68 -0.3 2.97e-8 Mean corpuscular hemoglobin; LUSC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg04414720 chr1:150670196 GOLPH3L 0.54 8.53 0.42 5.19e-16 Tonsillectomy; LUSC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg06618935 chr21:46677482 NA -0.4 -7.9 -0.4 4.09e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg18225595 chr11:63971243 STIP1 -0.53 -8.75 -0.43 1.06e-16 Platelet count; LUSC trans rs11098499 0.954 rs11940028 chr4:120411907 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.06 0.4 1.36e-14 Corneal astigmatism; LUSC cis rs10979 0.931 rs9484770 chr6:143896758 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs2012796 0.957 rs8016255 chr14:81816121 C/G cg02996355 chr14:81879375 NA 0.46 6.53 0.34 2.43e-10 Night sleep phenotypes; LUSC cis rs6545883 0.525 rs2049747 chr2:61364154 G/A cg15711740 chr2:61764176 XPO1 0.39 6.04 0.31 4.14e-9 Tuberculosis; LUSC cis rs6987853 0.931 rs2923399 chr8:42439509 G/A cg09913449 chr8:42400586 C8orf40 0.48 7.88 0.4 4.7e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg22681709 chr2:178499509 PDE11A -0.5 -9.06 -0.44 1.11e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9326248 0.539 rs518181 chr11:116772787 C/A cg01368799 chr11:117014884 PAFAH1B2 0.57 8.6 0.43 3.14e-16 Blood protein levels; LUSC trans rs61931739 0.500 rs34107854 chr12:34482333 C/A cg13010199 chr12:38710504 ALG10B 0.67 10.58 0.5 9.58e-23 Morning vs. evening chronotype; LUSC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg22968622 chr17:43663579 NA 0.8 12.38 0.56 3.25e-29 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs4478858 0.684 rs2271074 chr1:31734841 C/T cg00250761 chr1:31883323 NA -0.33 -8.06 -0.4 1.35e-14 Alcohol dependence; LUSC cis rs3820928 0.874 rs10210997 chr2:227859108 C/T cg11843606 chr2:227700838 RHBDD1 -0.46 -6.54 -0.34 2.29e-10 Pulmonary function; LUSC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.63 -8.77 -0.43 9.57e-17 Multiple sclerosis; LUSC cis rs10979 0.679 rs9496680 chr6:143896915 G/A cg25407410 chr6:143891975 LOC285740 -0.68 -9.53 -0.46 3.43e-19 Hypospadias; LUSC cis rs7561273 0.561 rs35268318 chr2:24352824 A/T cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC cis rs11190604 1.000 rs10883508 chr10:102294413 G/A cg23241863 chr10:102295624 HIF1AN 0.49 5.97 0.31 6.01e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1577917 1.000 rs12216328 chr6:86703418 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.49e-11 Response to antipsychotic treatment; LUSC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg14343924 chr8:8086146 FLJ10661 -0.42 -5.83 -0.3 1.33e-8 Mood instability; LUSC cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.55 0.42 4.63e-16 Menarche (age at onset); LUSC cis rs10465746 0.780 rs11163866 chr1:84367123 A/G cg10977910 chr1:84465055 TTLL7 0.45 6.36 0.33 6.7e-10 Obesity-related traits; LUSC cis rs9300255 0.596 rs11057207 chr12:123730891 T/G cg05973401 chr12:123451056 ABCB9 0.52 7.1 0.36 7.72e-12 Neutrophil percentage of white cells; LUSC cis rs690037 0.641 rs538525 chr3:16376279 A/G cg23474789 chr3:16306055 DPH3;OXNAD1 0.39 6.06 0.31 3.76e-9 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); LUSC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 8.12 0.41 9.33e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs611744 0.506 rs13280454 chr8:109263240 A/G cg18478394 chr8:109455254 TTC35 0.43 6.76 0.35 5.99e-11 Dupuytren's disease; LUSC cis rs3820068 0.705 rs57971278 chr1:15838604 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.8 0.3 1.5e-8 Systolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01084379 chr5:179160712 MAML1 -0.51 -6.62 -0.34 1.47e-10 Bipolar disorder and schizophrenia; LUSC cis rs10761482 0.861 rs10761485 chr10:62102660 T/C cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs273573 0.922 rs7930532 chr11:30811294 G/A cg14844989 chr11:31128820 NA -0.36 -5.72 -0.3 2.35e-8 Total body bone mineral density; LUSC cis rs2274273 0.624 rs7155954 chr14:55750943 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.8 0.47 4.34e-20 Protein biomarker; LUSC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg11941060 chr3:133502564 NA -0.51 -7.79 -0.39 8.5e-14 Iron status biomarkers; LUSC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg08392591 chr16:89556376 ANKRD11 0.46 6.92 0.35 2.38e-11 Multiple myeloma (IgH translocation); LUSC cis rs75804782 0.641 rs72983853 chr2:239324210 C/T cg18131467 chr2:239335373 ASB1 -0.71 -6.47 -0.33 3.41e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs10781543 0.839 rs4379550 chr9:139376426 C/T cg14169450 chr9:139327907 INPP5E -0.45 -8.06 -0.4 1.35e-14 Monocyte percentage of white cells; LUSC cis rs11601602 0.576 rs12576396 chr11:28555952 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.46 6.25 0.32 1.22e-9 Obesity-related traits; LUSC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg11062466 chr8:58055876 NA 0.51 6.49 0.33 3.08e-10 Developmental language disorder (linguistic errors); LUSC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03264133 chr6:25882463 NA -0.39 -6.51 -0.34 2.78e-10 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg10755058 chr3:40428713 ENTPD3 0.34 5.85 0.3 1.19e-8 Renal cell carcinoma; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg01125463 chr6:42946178 PEX6 -0.36 -6.11 -0.32 2.73e-9 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs804280 0.509 rs13276433 chr8:11783036 A/G cg15556689 chr8:8085844 FLJ10661 0.54 8.17 0.41 6.36e-15 Myopia (pathological); LUSC cis rs11711311 1.000 rs9854504 chr3:113532381 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.78 0.35 5.4e-11 IgG glycosylation; LUSC cis rs4242434 0.819 rs2306518 chr8:22470308 A/G cg03733263 chr8:22462867 KIAA1967 0.85 14.49 0.62 2.9e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2463822 0.858 rs2513077 chr11:62105925 A/G cg06239285 chr11:62104954 ASRGL1 -0.99 -11.03 -0.52 2.5300000000000002e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg06484146 chr7:12443880 VWDE -0.68 -7.26 -0.37 2.76e-12 Coronary artery disease; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07336999 chr16:89939803 TCF25 -0.35 -6.15 -0.32 2.21e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7177699 0.534 rs56683682 chr15:79112524 G/T cg00540400 chr15:79124168 NA -0.46 -7.9 -0.4 4.09e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7223966 0.960 rs2319990 chr17:61705397 T/C cg05941027 chr17:61774174 LIMD2 0.23 6.22 0.32 1.5e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs11098499 0.954 rs10014845 chr4:120301077 T/G cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs2075165 0.901 rs949464 chr1:156272271 C/T cg20302342 chr1:156215951 PAQR6 0.33 6.26 0.32 1.16e-9 Tonsillectomy; LUSC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg04362960 chr10:104952993 NT5C2 0.58 9.38 0.46 1.06e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg14440974 chr22:39074834 NA -0.36 -5.92 -0.31 7.79e-9 Menopause (age at onset); LUSC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg11344533 chr11:111475393 SIK2 -0.47 -6.33 -0.33 7.71e-10 Primary sclerosing cholangitis; LUSC cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg12615879 chr12:58013172 SLC26A10 -0.31 -7.59 -0.38 3.33e-13 Multiple sclerosis; LUSC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg16624210 chr5:671434 TPPP 0.49 6.12 0.32 2.58e-9 Lung disease severity in cystic fibrosis; LUSC cis rs12579753 0.833 rs12579530 chr12:82163930 A/C cg21231944 chr12:82153410 PPFIA2 -0.39 -6.3 -0.33 9.17e-10 Resting heart rate; LUSC cis rs10905065 0.965 rs10752110 chr10:5837038 T/C cg11519256 chr10:5708881 ASB13 0.4 5.78 0.3 1.7e-8 Menopause (age at onset); LUSC cis rs76935404 0.868 rs73034462 chr19:41418134 G/A cg04176888 chr19:41596066 CYP2A13 0.39 6.02 0.31 4.51e-9 nicotine metabolite ratio in current smokers; LUSC cis rs8060686 0.641 rs7204974 chr16:68033539 G/A cg27539214 chr16:67997921 SLC12A4 -0.55 -7.79 -0.39 8.57e-14 HDL cholesterol;Metabolic syndrome; LUSC cis rs6570726 0.526 rs7755237 chr6:145731852 T/C cg23711669 chr6:146136114 FBXO30 -0.51 -7.9 -0.4 4.05e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs637571 0.528 rs11602769 chr11:65594139 T/C cg26695010 chr11:65641043 EFEMP2 0.52 7.72 0.39 1.38e-13 Eosinophil percentage of white cells; LUSC cis rs722599 0.748 rs17102884 chr14:75374899 C/T cg06637938 chr14:75390232 RPS6KL1 -0.41 -6.07 -0.32 3.46e-9 IgG glycosylation; LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 14.73 0.63 3.3e-38 Platelet count; LUSC cis rs1801251 0.963 rs7591176 chr2:233581803 C/A cg08000102 chr2:233561755 GIGYF2 0.69 11.45 0.53 8.19e-26 Coronary artery disease; LUSC cis rs9420 0.961 rs77993055 chr11:57522840 C/T cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.22e-10 Schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16271017 chr6:7726349 BMP6 0.75 6.3 0.33 9.6e-10 Cognitive performance; LUSC cis rs17270561 0.609 rs4711097 chr6:25732314 C/T cg17691542 chr6:26056736 HIST1H1C 0.57 7.77 0.39 9.81e-14 Iron status biomarkers; LUSC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg16325326 chr1:53192061 ZYG11B -0.87 -16.47 -0.67 4.97e-45 Monocyte count; LUSC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg03233332 chr7:66118400 NA -0.42 -6.1 -0.32 2.88e-9 Aortic root size; LUSC cis rs911119 1.000 rs71334202 chr20:23618652 A/C cg16589663 chr20:23618590 CST3 0.58 6.89 0.35 2.72e-11 Chronic kidney disease; LUSC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg18538332 chr22:24372958 LOC391322 0.47 8.39 0.42 1.43e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6012953 0.967 rs4496379 chr20:49159944 A/T cg13958625 chr20:49123093 NA -0.29 -6.61 -0.34 1.55e-10 Vitiligo; LUSC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg04369109 chr6:150039330 LATS1 -0.49 -7.12 -0.36 6.51e-12 Lung cancer; LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg18404041 chr3:52824283 ITIH1 -0.58 -11.27 -0.52 3.48e-25 Bipolar disorder; LUSC cis rs9796 0.866 rs692155 chr15:41407061 A/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -8.06 -0.4 1.37e-14 Menopause (age at onset); LUSC cis rs8062405 1.000 rs7187776 chr16:28857645 A/G cg05966235 chr16:28915196 ATP2A1 0.34 6.15 0.32 2.26e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs2797160 1.000 rs61299898 chr6:126007651 G/C cg05039488 chr6:79577232 IRAK1BP1 0.45 6.66 0.34 1.16e-10 Endometrial cancer; LUSC cis rs9811920 0.732 rs793446 chr3:99578114 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.43 -6.4 -0.33 5.41e-10 Axial length; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg14004847 chr7:1930337 MAD1L1 -0.5 -7.5 -0.38 5.85e-13 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.59 8.31 0.41 2.46e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs4843747 0.636 rs11117358 chr16:88105053 T/A cg26811252 chr16:29126840 RRN3P2 0.57 9.08 0.44 9.35e-18 Menopause (age at onset); LUSC cis rs73206853 0.563 rs4073472 chr12:111176494 A/G cg12870014 chr12:110450643 ANKRD13A 0.69 7.34 0.37 1.62e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25249518 chr6:119399928 FAM184A -0.42 -6.28 -0.32 1.05e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10170846 0.861 rs12694582 chr2:223521955 G/C cg25565276 chr2:223520875 FARSB 0.64 9.7 0.47 9.46e-20 Schizophrenia (inflammation and infection response interaction); LUSC cis rs11971779 0.680 rs6949599 chr7:139054188 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.08 -0.32 3.35e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4919087 1.000 rs10786329 chr10:99074621 G/A cg25902810 chr10:99078978 FRAT1 0.47 6.91 0.35 2.47e-11 Monocyte count; LUSC trans rs17685 0.672 rs1639623 chr7:75707951 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.6 0.73 1.77e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10979 0.965 rs9376758 chr6:143886878 G/A cg25407410 chr6:143891975 LOC285740 -0.7 -11.06 -0.52 1.96e-24 Hypospadias; LUSC cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg19812747 chr11:111475976 SIK2 -0.51 -6.87 -0.35 3.24e-11 Primary sclerosing cholangitis; LUSC cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg24558204 chr6:135376177 HBS1L -0.47 -6.91 -0.35 2.49e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg21918786 chr6:109611834 NA -0.42 -7.29 -0.37 2.2e-12 Reticulocyte fraction of red cells; LUSC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg11342453 chr6:26196699 NA 0.58 6.07 0.32 3.4e-9 Gout;Renal underexcretion gout; LUSC trans rs61931739 1.000 rs11502817 chr12:34010676 T/C cg13010199 chr12:38710504 ALG10B -0.4 -5.97 -0.31 5.95e-9 Morning vs. evening chronotype; LUSC cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.45 -6.11 -0.32 2.73e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg22963979 chr7:1858916 MAD1L1 -0.63 -10.1 -0.48 4.03e-21 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg26380479 chr7:97908229 NA -0.28 -6.26 -0.32 1.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2732480 0.500 rs2450989 chr12:48653408 A/G cg04545296 chr12:48745243 ZNF641 -0.31 -5.78 -0.3 1.75e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4073582 0.894 rs801733 chr11:65934549 A/C cg16950941 chr11:66035639 RAB1B 0.44 5.74 0.3 2.1e-8 Gout; LUSC cis rs12042938 0.935 rs1094653 chr1:231794794 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.4 5.84 0.3 1.21e-8 Neuranatomic and neurocognitive phenotypes; LUSC cis rs5769707 0.604 rs1018814 chr22:50036900 T/C cg10356904 chr22:49881777 NA -0.29 -5.84 -0.3 1.25e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.65 -0.34 1.21e-10 Lung cancer; LUSC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg12927641 chr6:109611667 NA -0.35 -5.89 -0.31 9.49e-9 Reticulocyte fraction of red cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01571407 chr16:12009700 GSPT1 -0.4 -5.97 -0.31 6.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg18252515 chr7:66147081 NA -1.23 -14.17 -0.61 5.08e-36 Gout; LUSC cis rs7582180 0.629 rs2164847 chr2:100958715 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.77 0.3 1.81e-8 Intelligence (multi-trait analysis); LUSC cis rs9788721 0.933 rs72738786 chr15:78828086 G/T cg06917634 chr15:78832804 PSMA4 -0.47 -6.43 -0.33 4.35e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs10464366 0.843 rs6957662 chr7:39110829 C/T cg18850127 chr7:39170497 POU6F2 0.41 5.99 0.31 5.5e-9 IgG glycosylation; LUSC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -8.07 -0.4 1.28e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01172785 chr16:50092553 NA 0.53 6.47 0.33 3.57e-10 Bipolar disorder and schizophrenia; LUSC cis rs6693567 0.565 rs3754214 chr1:150478623 T/C cg15654264 chr1:150340011 RPRD2 0.46 7.5 0.38 5.73e-13 Migraine; LUSC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg02423579 chr7:2872169 GNA12 -0.37 -5.89 -0.31 9.44e-9 Height; LUSC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg08975724 chr8:8085496 FLJ10661 -0.63 -9.7 -0.47 9.24e-20 Neuroticism; LUSC cis rs826838 1.000 rs826891 chr12:39100824 A/G cg26384229 chr12:38710491 ALG10B -0.84 -15.9 -0.66 8.8e-43 Heart rate; LUSC cis rs11785400 0.793 rs35985277 chr8:143736137 C/T cg10596483 chr8:143751796 JRK 0.53 7.66 0.39 1.98e-13 Schizophrenia; LUSC trans rs1997103 1.000 rs4590393 chr7:55408990 C/T cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs672059 1.000 rs544352 chr1:183157546 G/A ch.1.3577855R chr1:183094577 LAMC1 0.55 7.98 0.4 2.3e-14 Hypertriglyceridemia; LUSC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg04998671 chr14:104000505 TRMT61A -0.42 -5.94 -0.31 7.19e-9 Reticulocyte count; LUSC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg08645402 chr16:4508243 NA 0.48 7.49 0.38 6.2e-13 Schizophrenia; LUSC cis rs2348418 0.647 rs938081 chr12:28720613 A/G cg13890972 chr12:28721907 NA -0.38 -6.6 -0.34 1.66e-10 Lung function (FVC);Lung function (FEV1); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03535439 chr6:42981950 MEA1;KLHDC3 -0.51 -6.05 -0.31 3.79e-9 Bipolar disorder and schizophrenia; LUSC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg17385448 chr1:15911702 AGMAT 0.37 6.24 0.32 1.29e-9 Systolic blood pressure; LUSC cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.13 0.55 2.61e-28 Motion sickness; LUSC cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg23711669 chr6:146136114 FBXO30 0.75 13.48 0.59 2.26e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs6599077 1.000 rs6768659 chr3:40097001 G/A cg13683864 chr3:40499215 RPL14 -0.58 -7.39 -0.38 1.15e-12 Sleep-related phenotypes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22207900 chr11:64072031 ESRRA;C11orf20 -0.42 -6.15 -0.32 2.26e-9 Hepatitis; LUSC cis rs77633900 0.614 rs279999 chr15:76945466 C/T cg21673338 chr15:77095150 SCAPER -0.74 -7.39 -0.37 1.19e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg11244672 chr19:19639970 YJEFN3 -0.53 -6.65 -0.34 1.19e-10 Bipolar disorder; LUSC cis rs9326248 1.000 rs7107152 chr11:117056080 C/T cg11861562 chr11:117069780 TAGLN -0.43 -7.83 -0.39 6.38e-14 Blood protein levels; LUSC cis rs7100689 0.646 rs2486302 chr10:82076600 G/A cg01528321 chr10:82214614 TSPAN14 0.82 12.36 0.56 3.74e-29 Post bronchodilator FEV1; LUSC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg04315214 chr1:2043799 PRKCZ -0.3 -5.88 -0.31 1.02e-8 Coronary artery disease; LUSC cis rs6430585 0.528 rs895285 chr2:136710554 A/G cg07169764 chr2:136633963 MCM6 1.13 17.44 0.69 6.81e-49 Corneal structure; LUSC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg20203395 chr5:56204925 C5orf35 -0.73 -9.96 -0.48 1.28e-20 Initial pursuit acceleration; LUSC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg06656553 chr16:89960601 TCF25 -0.63 -5.7 -0.3 2.68e-8 Skin colour saturation; LUSC cis rs9905704 0.647 rs12944274 chr17:57041293 C/G cg12560992 chr17:57184187 TRIM37 -0.54 -8.7 -0.43 1.49e-16 Testicular germ cell tumor; LUSC cis rs9300255 0.602 rs1727317 chr12:123618942 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -5.86 -0.31 1.11e-8 Neutrophil percentage of white cells; LUSC cis rs8114671 0.562 rs6120739 chr20:33405227 A/G cg24642439 chr20:33292090 TP53INP2 0.55 8.3 0.41 2.7e-15 Height; LUSC cis rs460214 0.564 rs464519 chr21:40024182 A/G cg21578987 chr21:40029669 ERG 0.42 6.48 0.33 3.39e-10 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs7100689 0.646 rs4468295 chr10:82119276 C/G cg00277334 chr10:82204260 NA -0.54 -7.92 -0.4 3.59e-14 Post bronchodilator FEV1; LUSC cis rs7264396 0.887 rs224419 chr20:34143092 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.99 -0.36 1.51e-11 Total cholesterol levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26643937 chr20:3869678 PANK2 0.77 6.05 0.31 3.81e-9 Cognitive performance; LUSC cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs6433857 0.657 rs2368177 chr2:181501242 T/C cg23363182 chr2:181467187 NA -0.53 -8.44 -0.42 9.86e-16 Body mass index; LUSC cis rs1385374 0.858 rs11059923 chr12:129293057 G/A cg09035930 chr12:129282057 SLC15A4 -0.64 -6.8 -0.35 4.96e-11 Systemic lupus erythematosus; LUSC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg14019146 chr3:50243930 SLC38A3 0.32 6.93 0.35 2.17e-11 Intelligence (multi-trait analysis); LUSC cis rs7681440 0.869 rs7680557 chr4:90763360 C/A cg20003494 chr4:90757398 SNCA -0.33 -5.68 -0.3 2.91e-8 Dementia with Lewy bodies; LUSC cis rs9372253 0.843 rs28721292 chr6:110719631 T/C cg00083206 chr6:110721305 DDO -0.46 -8.42 -0.42 1.1e-15 Platelet distribution width; LUSC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg12963246 chr6:28129442 ZNF389 0.49 6.73 0.35 7.47e-11 Depression; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05131254 chr6:138188363 TNFAIP3 0.46 6.28 0.32 1.08e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg17264618 chr3:40429014 ENTPD3 0.31 6.65 0.34 1.19e-10 Renal cell carcinoma; LUSC cis rs17818399 0.749 rs4142759 chr2:46783890 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.57 -7.57 -0.38 3.56e-13 Height; LUSC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg25072359 chr17:41440525 NA 0.65 9.46 0.46 5.86e-19 Menopause (age at onset); LUSC cis rs7312933 0.531 rs2406674 chr12:42720150 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.84 -0.35 3.74e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs17780086 0.527 rs72827712 chr17:30538600 A/G cg20587970 chr11:113659929 NA -1.18 -11.77 -0.54 5.7e-27 Height; LUSC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -6.96 -0.36 1.8e-11 Major depressive disorder; LUSC cis rs11122272 0.668 rs2472261 chr1:231505701 G/A cg06096015 chr1:231504339 EGLN1 0.56 9.95 0.48 1.36e-20 Hemoglobin concentration; LUSC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg05234568 chr11:5960015 NA -0.57 -8.29 -0.41 2.76e-15 DNA methylation (variation); LUSC cis rs11098499 0.863 rs34308924 chr4:120481431 T/C cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs11971779 0.590 rs9642120 chr7:139083971 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.28e-9 Menopause (age at onset); LUSC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.72 -12.8 -0.57 8.73e-31 Personality dimensions; LUSC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg08392591 chr16:89556376 ANKRD11 0.44 6.73 0.35 7.29e-11 Multiple myeloma (IgH translocation); LUSC cis rs7586879 0.796 rs916484 chr2:25082588 A/C cg01884057 chr2:25150051 NA 0.39 7.93 0.4 3.42e-14 Body mass index; LUSC cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg06064525 chr11:970664 AP2A2 -0.49 -10.75 -0.51 2.37e-23 Alzheimer's disease (late onset); LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 11.08 0.52 1.69e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg15704280 chr7:45808275 SEPT13 -1.08 -19.79 -0.73 3.07e-58 Coronary artery disease; LUSC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg17366294 chr4:99064904 C4orf37 0.55 9.78 0.47 4.99e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9820353 1 rs9820353 chr3:142299926 A/G cg16271453 chr3:142027066 XRN1 -0.35 -5.91 -0.31 8.62e-9 Mean corpuscular volume; LUSC trans rs3857536 0.813 rs1029400 chr6:66952385 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -5.99 -0.31 5.34e-9 Blood trace element (Cu levels); LUSC cis rs56804039 0.895 rs11776995 chr8:8385547 A/G cg15556689 chr8:8085844 FLJ10661 -0.58 -7.19 -0.37 4.18e-12 Cervical cancer; LUSC trans rs11098499 0.954 rs56270433 chr4:120406030 C/T cg25214090 chr10:38739885 LOC399744 0.54 8.05 0.4 1.44e-14 Corneal astigmatism; LUSC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs4363385 0.818 rs1591736 chr1:152987497 A/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.75 -0.3 2e-8 Inflammatory skin disease; LUSC trans rs7824557 0.767 rs3808509 chr8:11163256 G/T cg15556689 chr8:8085844 FLJ10661 0.56 8.58 0.42 3.52e-16 Retinal vascular caliber; LUSC cis rs13256369 0.950 rs13255655 chr8:8577736 C/T cg18904891 chr8:8559673 CLDN23 0.59 7.67 0.39 1.92e-13 Obesity-related traits; LUSC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg25036284 chr2:26402008 FAM59B -0.67 -9.69 -0.47 1.02e-19 Gut microbiome composition (summer); LUSC cis rs888194 0.587 rs6606711 chr12:109849297 A/G cg19025524 chr12:109796872 NA -0.36 -6.21 -0.32 1.6e-9 Neuroticism; LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg14092988 chr3:52407081 DNAH1 0.32 6.34 0.33 7.25e-10 Bipolar disorder; LUSC cis rs2742234 0.590 rs2565201 chr10:43618484 T/C cg15436174 chr10:43711423 RASGEF1A -0.45 -7.48 -0.38 6.74e-13 Hirschsprung disease; LUSC trans rs459571 0.959 rs416390 chr9:136908549 C/G cg10765909 chr12:53715428 AAAS 0.41 5.96 0.31 6.24e-9 Platelet distribution width; LUSC cis rs11190604 0.767 rs11190534 chr10:102190930 G/A cg07080220 chr10:102295463 HIF1AN 0.61 8.15 0.41 7.58e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.6 0.38 3.08e-13 Bipolar disorder; LUSC cis rs2795502 1.000 rs2185717 chr10:43343875 G/A cg20628663 chr10:43360327 NA 0.76 11.26 0.52 3.79e-25 Blood protein levels; LUSC cis rs7223966 1.000 rs8075061 chr17:61804723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.92 0.35 2.31e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg07092213 chr7:1199455 ZFAND2A -0.53 -7.84 -0.39 5.95e-14 Longevity;Endometriosis; LUSC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg06505273 chr16:24850292 NA 0.4 5.77 0.3 1.8e-8 Intelligence (multi-trait analysis); LUSC cis rs12900413 0.687 rs35060998 chr15:90310294 A/G cg24249390 chr15:90295951 MESP1 -0.37 -5.91 -0.31 8.6e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs6087771 0.651 rs6060775 chr20:30286191 A/G cg13852791 chr20:30311386 BCL2L1 0.63 9.23 0.45 3.17e-18 Subcortical brain region volumes;Putamen volume; LUSC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg18252515 chr7:66147081 NA -1.24 -13.96 -0.61 3.38e-35 Diabetic kidney disease; LUSC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg08045932 chr20:61659980 NA 0.59 10.39 0.49 4.41e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.13 -0.36 6.2e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs11992162 0.551 rs13268217 chr8:11782609 T/A cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.46e-10 Monocyte count; LUSC cis rs9399401 0.667 rs6903424 chr6:142699948 A/C cg03128060 chr6:142623767 GPR126 0.57 9.5 0.46 4.18e-19 Chronic obstructive pulmonary disease; LUSC cis rs2404602 0.684 rs11854850 chr15:76844571 C/T cg23625390 chr15:77176239 SCAPER -0.64 -9.7 -0.47 8.97e-20 Blood metabolite levels; LUSC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.71 -0.3 2.55e-8 Life satisfaction; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg06382786 chr17:57297815 GDPD1 0.37 6.18 0.32 1.87e-9 Educational attainment (years of education); LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg11764359 chr7:65958608 NA -0.7 -10.7 -0.51 3.47e-23 Aortic root size; LUSC cis rs782590 0.935 rs782606 chr2:55886602 T/C cg03859395 chr2:55845619 SMEK2 0.88 16.5 0.67 3.62e-45 Metabolic syndrome; LUSC cis rs8060686 0.545 rs3815173 chr16:68160289 T/G cg27539214 chr16:67997921 SLC12A4 -0.6 -7.17 -0.37 4.72e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs1568889 1.000 rs33937991 chr11:28045260 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19815055 chr5:36876667 NIPBL -0.49 -7.23 -0.37 3.28e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg22638593 chr5:131593259 PDLIM4 0.48 7.3 0.37 2.06e-12 Acylcarnitine levels; LUSC cis rs7296418 0.636 rs11057261 chr12:123797567 T/C cg13010344 chr12:123464640 ARL6IP4 -0.49 -7.93 -0.4 3.27e-14 Platelet count; LUSC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg09034736 chr1:150693464 HORMAD1 0.43 5.93 0.31 7.46e-9 Melanoma; LUSC trans rs9409565 0.826 rs4744338 chr9:97158965 C/T cg05679027 chr9:99775184 HIATL2 0.46 6.81 0.35 4.6e-11 Colorectal cancer (alcohol consumption interaction); LUSC cis rs7577696 0.597 rs56322034 chr2:32353013 T/C cg02381751 chr2:32503542 YIPF4 -0.52 -6.98 -0.36 1.63e-11 Inflammatory biomarkers; LUSC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.81 7.68 0.39 1.79e-13 Cerebrospinal P-tau181p levels; LUSC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg16049864 chr8:95962084 TP53INP1 -0.43 -7.18 -0.37 4.47e-12 Type 2 diabetes; LUSC cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg24690094 chr11:67383802 NA -0.44 -8.31 -0.41 2.5e-15 Mean corpuscular volume; LUSC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.1 0.48 4.14e-21 Electroencephalogram traits; LUSC cis rs1034435 0.755 rs5767173 chr22:48892473 T/C cg05992904 chr22:48892994 FAM19A5 -0.41 -8.26 -0.41 3.47e-15 Late-onset Alzheimer's disease; LUSC cis rs3020736 0.500 rs11090076 chr22:42514190 T/C cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs6547741 1.000 rs6547734 chr2:27830990 G/T cg12559939 chr2:27858050 GPN1 0.41 6.44 0.33 4.16e-10 Oral cavity cancer; LUSC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg15664640 chr17:80829946 TBCD -0.46 -7.63 -0.39 2.51e-13 Breast cancer; LUSC trans rs1874124 0.836 rs17596947 chr1:220993464 A/C cg00338749 chr11:1036677 MUC6 -0.39 -6.23 -0.32 1.44e-9 Cholesterol, total; LUSC cis rs2295359 0.824 rs4655679 chr1:67599657 A/G cg17031739 chr1:67600172 NA -0.48 -7.68 -0.39 1.8e-13 Psoriasis; LUSC cis rs2235544 0.565 rs650134 chr1:54467342 T/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs72772090 0.539 rs11749811 chr5:96115925 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.78 -0.35 5.49e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7188861 0.724 rs12924957 chr16:11403766 C/T cg00044050 chr16:11439710 C16orf75 0.58 6.2 0.32 1.67e-9 HDL cholesterol; LUSC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.47e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs1982963 1.000 rs753051 chr14:52505360 A/G cg10843707 chr14:52510701 NID2 -0.41 -6.6 -0.34 1.62e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12474201 0.572 rs7596521 chr2:46918665 A/G cg06386533 chr2:46925753 SOCS5 0.52 6.75 0.35 6.57e-11 Height; LUSC cis rs6754311 0.731 rs892715 chr2:136576577 T/C cg25344623 chr2:136566232 LCT 0.38 5.73 0.3 2.27e-8 Mosquito bite size; LUSC cis rs367615 0.513 rs11741087 chr5:108807760 G/A cg17395555 chr5:108820864 NA 0.62 11.28 0.53 3.27e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs45535039 0.506 rs2511856 chr11:119144148 A/C cg23558831 chr11:118978103 C2CD2L -0.41 -5.96 -0.31 6.38e-9 Plateletcrit; LUSC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg24209194 chr3:40518798 ZNF619 0.45 6.06 0.31 3.69e-9 Renal cell carcinoma; LUSC cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg21770322 chr7:97807741 LMTK2 0.47 8.0 0.4 2.04e-14 Breast cancer; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg05064044 chr6:292385 DUSP22 -0.71 -11.55 -0.53 3.53e-26 Menopause (age at onset); LUSC cis rs9462027 0.628 rs2814968 chr6:34713138 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.87 -0.31 1.02e-8 Systemic lupus erythematosus; LUSC cis rs7605827 0.930 rs1990753 chr2:15612403 G/C cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg16606324 chr3:10149918 C3orf24 0.64 9.39 0.46 9.87e-19 Alzheimer's disease; LUSC cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg05985134 chr18:33552581 C18orf21 0.5 6.73 0.35 7.22e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs2692947 0.711 rs56791141 chr2:96587496 C/T cg22654517 chr2:96458247 NA 0.38 7.64 0.39 2.39e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10751667 0.961 rs10794358 chr11:985547 C/T ch.11.42038R chr11:967971 AP2A2 0.54 7.86 0.4 5.22e-14 Alzheimer's disease (late onset); LUSC cis rs2439831 0.850 rs56909447 chr15:44137618 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.91 0.35 2.39e-11 Lung cancer in ever smokers; LUSC cis rs1775715 0.870 rs11008700 chr10:32236937 A/G cg18675610 chr10:32216311 ARHGAP12 0.28 5.86 0.31 1.11e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg12963246 chr6:28129442 ZNF389 0.41 6.45 0.33 3.99e-10 Parkinson's disease; LUSC cis rs977987 0.843 rs11641801 chr16:75455448 A/C cg03315344 chr16:75512273 CHST6 0.49 9.24 0.45 2.9e-18 Dupuytren's disease; LUSC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg06740227 chr12:86229804 RASSF9 0.44 7.05 0.36 1.01e-11 Major depressive disorder; LUSC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg12463550 chr7:65579703 CRCP 0.56 8.33 0.41 2.17e-15 Aortic root size; LUSC cis rs11971779 0.648 rs10085708 chr7:139110954 A/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs983392 0.792 rs1303615 chr11:59885120 C/T cg24026212 chr11:59952134 MS4A6A -0.31 -5.8 -0.3 1.52e-8 Alzheimer's disease (late onset); LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg19318889 chr4:1322082 MAEA 0.47 7.52 0.38 4.99e-13 Obesity-related traits; LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg22963979 chr7:1858916 MAD1L1 -0.55 -8.39 -0.42 1.43e-15 Bipolar disorder and schizophrenia; LUSC trans rs2236293 0.754 rs10814276 chr9:35794913 T/A cg11239633 chr3:37903682 CTDSPL -0.36 -6.54 -0.34 2.34e-10 Blood protein levels; LUSC trans rs561341 1.000 rs501957 chr17:30314504 C/T cg20587970 chr11:113659929 NA -1.33 -17.68 -0.7 7.86e-50 Hip circumference adjusted for BMI; LUSC cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg00074818 chr8:8560427 CLDN23 0.58 9.85 0.47 2.86e-20 Obesity-related traits; LUSC trans rs72792513 1.000 rs7590019 chr2:22920470 A/G cg05844895 chr16:88969569 CBFA2T3 0.5 6.2 0.32 1.69e-9 Hepatitis B; LUSC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.83 0.3 1.3e-8 Intelligence (multi-trait analysis); LUSC cis rs926938 0.527 rs360580 chr1:115462334 A/G cg01522456 chr1:115632236 TSPAN2 -0.41 -6.44 -0.33 4.23e-10 Autism; LUSC cis rs72781680 0.898 rs6712175 chr2:24023431 T/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs2235649 0.798 rs9922462 chr16:1848011 C/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -5.97 -0.31 6.02e-9 Blood metabolite levels; LUSC cis rs10876993 0.789 rs1689600 chr12:58049645 A/T cg15848620 chr12:58087721 OS9 -0.52 -7.56 -0.38 3.89e-13 Celiac disease or Rheumatoid arthritis; LUSC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg03929089 chr4:120376271 NA -0.94 -16.5 -0.67 3.92e-45 Height; LUSC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.84 0.47 3.11e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.863 rs11723090 chr4:120490592 T/C cg09307838 chr4:120376055 NA 0.75 10.82 0.51 1.32e-23 Corneal astigmatism; LUSC cis rs754466 0.580 rs2289308 chr10:79579251 G/A cg17075019 chr10:79541650 NA -0.78 -12.37 -0.56 3.35e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7824557 0.527 rs4634600 chr8:11239017 T/A cg06636001 chr8:8085503 FLJ10661 -0.49 -7.64 -0.39 2.39e-13 Retinal vascular caliber; LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg02018176 chr4:1364513 KIAA1530 0.74 13.47 0.59 2.59e-33 Longevity; LUSC trans rs804280 1.000 rs804281 chr8:11611865 A/G cg27411982 chr8:10470053 RP1L1 0.45 6.68 0.34 9.8e-11 Myopia (pathological); LUSC cis rs7615952 0.673 rs35001498 chr3:125628644 A/G cg05084668 chr3:125655381 ALG1L -0.9 -12.91 -0.58 3.16e-31 Blood pressure (smoking interaction); LUSC cis rs2224391 0.911 rs6925249 chr6:5262510 G/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.72 -0.35 7.76e-11 Height; LUSC cis rs877282 0.945 rs11253396 chr10:789754 C/T cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg08355456 chr11:67383691 NA 0.38 7.08 0.36 8.31e-12 Mean corpuscular volume; LUSC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg03806693 chr22:41940476 POLR3H -1.03 -13.9 -0.61 5.73e-35 Vitiligo; LUSC cis rs7523273 0.606 rs2724391 chr1:207953244 T/C cg22525895 chr1:207977042 MIR29B2 0.43 6.92 0.35 2.28e-11 Schizophrenia; LUSC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg26354017 chr1:205819088 PM20D1 -0.47 -7.23 -0.37 3.34e-12 Menarche (age at onset); LUSC cis rs3540 0.597 rs3539 chr15:91045419 G/T cg10434728 chr15:90938212 IQGAP1 -0.45 -9.14 -0.45 6.2e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs977987 0.806 rs12933281 chr16:75483064 T/G cg03315344 chr16:75512273 CHST6 0.48 9.36 0.46 1.2e-18 Dupuytren's disease; LUSC cis rs240764 0.817 rs239189 chr6:101128787 C/T cg09795085 chr6:101329169 ASCC3 0.42 6.11 0.32 2.83e-9 Neuroticism; LUSC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg15556689 chr8:8085844 FLJ10661 0.68 10.48 0.5 2.13e-22 Mood instability; LUSC cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg17143192 chr8:8559678 CLDN23 0.64 9.14 0.45 6.38e-18 Obesity-related traits; LUSC cis rs1355223 0.583 rs2956074 chr11:34864880 T/C cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.4 -0.38 1.1e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2273669 0.504 rs1539596 chr6:109408428 C/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.8 -0.3 1.57e-8 Prostate cancer; LUSC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg12365402 chr11:9010492 NRIP3 -0.51 -9.81 -0.47 4.04e-20 Hemoglobin concentration; LUSC cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg24812749 chr6:127587940 RNF146 0.81 11.76 0.54 5.83e-27 Breast cancer; LUSC cis rs6545883 0.929 rs2252662 chr2:61670731 T/C cg15711740 chr2:61764176 XPO1 -0.45 -6.84 -0.35 3.69e-11 Tuberculosis; LUSC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.85 -0.63 1.22e-38 Total body bone mineral density; LUSC cis rs11610422 1.000 rs34325065 chr12:31414505 C/G cg14306366 chr12:31406441 NA -0.55 -6.6 -0.34 1.58e-10 Coronary artery disease; LUSC trans rs2727020 0.553 rs4103567 chr11:49255389 C/T cg21153622 chr11:89784906 NA -0.44 -6.85 -0.35 3.55e-11 Coronary artery disease; LUSC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg11344533 chr11:111475393 SIK2 0.46 6.25 0.32 1.25e-9 Primary sclerosing cholangitis; LUSC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs208520 0.909 rs58958359 chr6:67021381 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 8.76 0.43 9.74e-17 Exhaled nitric oxide output; LUSC cis rs796364 0.616 rs2103094 chr2:200687954 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.9 0.31 8.74e-9 Schizophrenia; LUSC trans rs2204008 0.660 rs2320745 chr12:38239101 T/C cg06521331 chr12:34319734 NA -0.41 -6.41 -0.33 5.01e-10 Bladder cancer; LUSC cis rs1443512 0.588 rs3759162 chr12:54331154 G/C cg17410650 chr12:54324560 NA -0.43 -5.79 -0.3 1.61e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1728785 0.818 rs1728772 chr16:68584526 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg12963246 chr6:28129442 ZNF389 0.43 6.04 0.31 4.16e-9 Depression; LUSC cis rs7584330 0.695 rs77922291 chr2:238366317 T/G cg14458575 chr2:238380390 NA 0.67 11.78 0.54 5.17e-27 Prostate cancer; LUSC cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg25801113 chr15:45476975 SHF 0.36 7.32 0.37 1.82e-12 Uric acid levels; LUSC cis rs68170813 0.559 rs78888729 chr7:106940957 G/C cg02696742 chr7:106810147 HBP1 -0.64 -9.72 -0.47 7.9e-20 Coronary artery disease; LUSC cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.67 0.65 7.43e-42 Bladder cancer; LUSC trans rs12210905 0.925 rs115507154 chr6:26970811 C/A cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg10130564 chr11:117069849 TAGLN 0.31 6.0 0.31 5.07e-9 Blood protein levels; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg03579872 chr1:53393473 SCP2 -0.39 -5.87 -0.31 1.05e-8 Monocyte count; LUSC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg09655341 chr17:79618100 PDE6G -0.29 -6.88 -0.35 3.01e-11 Eye color traits; LUSC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg12311346 chr5:56204834 C5orf35 0.57 7.93 0.4 3.32e-14 Coronary artery disease; LUSC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg04414720 chr1:150670196 GOLPH3L -0.49 -7.87 -0.4 4.85e-14 Melanoma; LUSC cis rs12410462 0.581 rs111356515 chr1:227537236 C/G cg23173402 chr1:227635558 NA 0.56 6.52 0.34 2.52e-10 Major depressive disorder; LUSC cis rs4820539 0.966 rs2283803 chr22:23454881 G/A cg21100191 chr22:23484243 RTDR1 0.9 15.38 0.64 9.59e-41 Bone mineral density; LUSC cis rs887829 0.641 rs10179094 chr2:234597825 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -6.72 -0.34 8.08e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs6061231 0.740 rs11698650 chr20:60958374 A/T cg22601191 chr20:60968625 CABLES2 0.4 6.73 0.35 7.57e-11 Colorectal cancer; LUSC cis rs7474896 0.561 rs2474603 chr10:38445682 C/T cg25427524 chr10:38739819 LOC399744 -0.52 -6.38 -0.33 5.9e-10 Obesity (extreme); LUSC cis rs243505 0.762 rs734002 chr7:148505788 A/G cg09806900 chr7:148480153 CUL1 0.55 8.08 0.4 1.16e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.55 -10.71 -0.51 3.22e-23 Birth weight; LUSC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg04369109 chr6:150039330 LATS1 -0.53 -7.93 -0.4 3.27e-14 Lung cancer; LUSC cis rs12760731 0.720 rs2175254 chr1:178319105 G/A cg00404053 chr1:178313656 RASAL2 0.61 6.31 0.33 8.63e-10 Obesity-related traits; LUSC cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg11764359 chr7:65958608 NA 0.8 12.76 0.57 1.17e-30 Aortic root size; LUSC cis rs10186029 0.539 rs4672676 chr2:214001948 C/T cg08319019 chr2:214017104 IKZF2 0.49 7.51 0.38 5.55e-13 Systemic sclerosis; LUSC cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.3 -0.45 1.87e-18 Schizophrenia; LUSC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg20701182 chr2:24300061 SF3B14 -0.88 -11.39 -0.53 1.34e-25 Lymphocyte counts; LUSC cis rs6456156 0.792 rs2039321 chr6:167516299 C/T cg07741184 chr6:167504864 NA 0.38 6.71 0.34 8.4e-11 Primary biliary cholangitis; LUSC cis rs4664304 0.770 rs55860731 chr2:160875437 C/T cg23995753 chr2:160760732 LY75 -0.34 -6.38 -0.33 5.9e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs11229555 0.874 rs10896788 chr11:58292976 G/A cg15696309 chr11:58395628 NA -0.7 -8.83 -0.43 6.16e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs7681440 0.904 rs28507349 chr4:90767063 G/A cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.0 -0.31 5.05e-9 Dementia with Lewy bodies; LUSC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.958 rs34994386 chr6:86524135 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.22 -0.32 1.48e-9 Response to antipsychotic treatment; LUSC cis rs80130819 0.515 rs1793956 chr12:48392914 C/G cg05342945 chr12:48394962 COL2A1 -0.43 -5.72 -0.3 2.36e-8 Prostate cancer; LUSC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg24110177 chr3:50126178 RBM5 -0.61 -10.39 -0.49 4.29e-22 Body mass index; LUSC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.01 0.4 1.97e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg22340644 chr7:75368344 HIP1 -0.52 -6.66 -0.34 1.14e-10 Neuroticism; LUSC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg08270630 chr22:50330655 NA -0.44 -6.71 -0.34 8.57e-11 Schizophrenia; LUSC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg00701064 chr4:6280414 WFS1 0.48 10.36 0.49 5.58e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg03264133 chr6:25882463 NA -0.45 -7.68 -0.39 1.77e-13 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg13395646 chr4:1353034 KIAA1530 -0.63 -10.15 -0.49 2.93e-21 Obesity-related traits; LUSC cis rs11608355 0.515 rs61941631 chr12:109935475 C/T cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg08680598 chr22:49984980 NA -0.33 -6.09 -0.32 3.16e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7336332 0.598 rs12018313 chr13:28012266 C/A cg22138327 chr13:27999177 GTF3A 0.8 9.82 0.47 3.7e-20 Weight; LUSC cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg05855489 chr10:104503620 C10orf26 0.64 9.06 0.44 1.15e-17 Arsenic metabolism; LUSC cis rs4622329 0.636 rs7974969 chr12:102288423 A/G cg23541617 chr12:102225335 GNPTAB 0.27 6.2 0.32 1.62e-9 Systemic lupus erythematosus; LUSC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC trans rs6828577 0.862 rs298983 chr4:119604802 C/T cg26518628 chr1:97050305 NA 0.41 6.03 0.31 4.37e-9 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC cis rs709400 0.691 rs12888077 chr14:103872553 G/T cg10523860 chr14:103875565 MARK3 0.39 6.4 0.33 5.11e-10 Body mass index; LUSC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg00933542 chr6:150070202 PCMT1 0.33 6.84 0.35 3.82e-11 Lung cancer; LUSC cis rs2797160 0.967 rs2747715 chr6:126007719 A/T cg05901451 chr6:126070800 HEY2 0.57 8.51 0.42 5.97e-16 Endometrial cancer; LUSC cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg24692254 chr21:30365293 RNF160 -0.76 -13.99 -0.61 2.46e-35 Dental caries; LUSC trans rs35110281 0.591 rs86139 chr21:44932802 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 10.09 0.48 4.36e-21 Mean corpuscular volume; LUSC cis rs12908161 0.853 rs12912342 chr15:85248216 T/C cg17173187 chr15:85201210 NMB 0.41 8.02 0.4 1.81e-14 Schizophrenia; LUSC cis rs7296418 0.961 rs10773921 chr12:123541606 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -7.16 -0.36 5.16e-12 Platelet count; LUSC cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg23711669 chr6:146136114 FBXO30 0.88 16.26 0.66 3.3e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.69 10.62 0.5 7.09e-23 Lymphocyte counts; LUSC trans rs11039798 0.541 rs12283728 chr11:48796407 G/A cg03929089 chr4:120376271 NA 0.72 6.77 0.35 5.71e-11 Axial length; LUSC cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg11266682 chr4:10021025 SLC2A9 0.53 10.0 0.48 9.15e-21 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.2 -0.37 4.02e-12 Bipolar disorder; LUSC cis rs4947962 0.585 rs759170 chr7:55155372 C/T cg23757825 chr7:55092271 EGFR -0.46 -5.66 -0.3 3.21e-8 Subjective response to lithium treatment; LUSC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg22800045 chr5:56110881 MAP3K1 -0.63 -8.77 -0.43 9.14e-17 Initial pursuit acceleration; LUSC cis rs8060686 0.641 rs55790290 chr16:68180242 A/G cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25020728 chr12:123011538 RSRC2;KNTC1 -0.4 -6.02 -0.31 4.53e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9902453 0.934 rs7211246 chr17:28485762 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.5 7.63 0.39 2.52e-13 Coffee consumption (cups per day); LUSC cis rs2658782 0.704 rs2605614 chr11:93232745 A/G cg15737290 chr11:93063684 CCDC67 0.63 8.12 0.41 9.26e-15 Pulmonary function decline; LUSC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg00343986 chr7:65444356 GUSB 0.46 6.63 0.34 1.39e-10 Aortic root size; LUSC cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.32 0.37 1.82e-12 Motion sickness; LUSC cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg05985134 chr18:33552581 C18orf21 0.51 6.92 0.35 2.35e-11 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs9329221 0.537 rs1484640 chr8:9983243 G/T cg06636001 chr8:8085503 FLJ10661 0.49 7.16 0.36 5.1e-12 Neuroticism; LUSC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.81 15.41 0.64 7.74e-41 Total body bone mineral density; LUSC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg02753203 chr1:228287806 NA -0.74 -13.37 -0.59 6.01e-33 Diastolic blood pressure; LUSC trans rs12709013 0.636 rs1646268 chr16:58777196 A/G cg19313373 chr1:162694184 DDR2 -0.35 -6.01 -0.31 4.91e-9 Blood metabolite ratios; LUSC cis rs9811920 0.809 rs6806323 chr3:99722564 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.71 -0.34 8.18e-11 Axial length; LUSC cis rs548181 0.604 rs11608103 chr11:125627917 G/A cg03464685 chr11:125439445 EI24 -0.9 -10.92 -0.51 6.21e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg18200150 chr17:30822561 MYO1D 0.48 10.06 0.48 5.83e-21 Schizophrenia; LUSC cis rs722599 0.748 rs1059326 chr14:75369385 C/T cg06637938 chr14:75390232 RPS6KL1 -0.41 -6.02 -0.31 4.47e-9 IgG glycosylation; LUSC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg27144592 chr16:783916 NARFL 0.37 5.66 0.3 3.34e-8 Height; LUSC cis rs7829975 0.577 rs940032 chr8:8546343 C/T cg18904891 chr8:8559673 CLDN23 -0.39 -5.69 -0.3 2.77e-8 Mood instability; LUSC cis rs1784581 1.000 rs1784582 chr6:162400712 A/G cg17173639 chr6:162384350 PARK2 -0.81 -14.8 -0.63 1.77e-38 Itch intensity from mosquito bite; LUSC cis rs9788682 0.747 rs2656069 chr15:78745707 C/T cg18825076 chr15:78729989 IREB2 -0.45 -6.24 -0.32 1.3e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9326248 0.954 rs8521 chr11:117067699 C/T cg15534755 chr11:117069859 TAGLN 0.33 5.79 0.3 1.66e-8 Blood protein levels; LUSC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg15145296 chr3:125709740 NA -0.58 -6.57 -0.34 1.95e-10 Blood pressure (smoking interaction); LUSC cis rs1983891 0.955 rs7753653 chr6:41548430 C/T cg15051332 chr6:41514432 FOXP4 -0.39 -5.77 -0.3 1.84e-8 Prostate cancer; LUSC cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg24692254 chr21:30365293 RNF160 -0.53 -8.01 -0.4 1.92e-14 Dental caries; LUSC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.51 0.34 2.72e-10 Renal cell carcinoma; LUSC cis rs425277 1.000 rs421992 chr1:2077260 C/T cg24578937 chr1:2090814 PRKCZ 0.6 13.76 0.6 1.92e-34 Height; LUSC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.4 5.67 0.3 3.1e-8 Schizophrenia; LUSC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg22823121 chr1:150693482 HORMAD1 0.59 9.09 0.45 8.83e-18 Melanoma; LUSC cis rs9329221 0.905 rs13252982 chr8:10255105 C/G cg27411982 chr8:10470053 RP1L1 -0.51 -8.08 -0.4 1.22e-14 Neuroticism; LUSC cis rs2070488 0.965 rs1058945 chr3:38532511 A/G cg24069376 chr3:38537580 EXOG -0.48 -10.23 -0.49 1.5e-21 Electrocardiographic conduction measures; LUSC cis rs1322512 0.754 rs1405691 chr6:152936650 C/T cg27316956 chr6:152958899 SYNE1 0.34 5.75 0.3 1.99e-8 Tonometry; LUSC cis rs9309473 0.607 rs6546826 chr2:73599808 A/G cg20560298 chr2:73613845 ALMS1 0.58 8.58 0.42 3.67e-16 Metabolite levels; LUSC cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg00579200 chr11:133705235 NA -0.38 -5.93 -0.31 7.44e-9 Childhood ear infection; LUSC cis rs11992162 0.591 rs35657308 chr8:11804402 G/A cg21775007 chr8:11205619 TDH -0.44 -6.15 -0.32 2.27e-9 Monocyte count; LUSC cis rs7674212 0.570 rs6841136 chr4:104103509 A/C cg16532752 chr4:104119610 CENPE -0.46 -7.05 -0.36 1.01e-11 Type 2 diabetes; LUSC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg05472934 chr7:22766657 IL6 0.5 7.84 0.39 6.13e-14 Lung cancer; LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg19346786 chr7:2764209 NA -0.51 -8.72 -0.43 1.29e-16 Height; LUSC cis rs4478858 0.735 rs12408524 chr1:31835853 A/G cg00250761 chr1:31883323 NA -0.37 -8.85 -0.44 5.18e-17 Alcohol dependence; LUSC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg21770322 chr7:97807741 LMTK2 -0.41 -7.2 -0.37 3.99e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.863 rs6858592 chr4:120458692 G/A cg09307838 chr4:120376055 NA 0.74 10.45 0.5 2.69e-22 Corneal astigmatism; LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.76 0.35 5.99e-11 Menopause (age at onset); LUSC cis rs1538970 0.816 rs34673142 chr1:45985561 G/A cg06784218 chr1:46089804 CCDC17 0.34 5.85 0.3 1.16e-8 Platelet count; LUSC cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg05340658 chr4:99064831 C4orf37 0.62 10.47 0.5 2.21e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs8014204 0.544 rs2286913 chr14:75386576 G/A cg06637938 chr14:75390232 RPS6KL1 0.85 15.56 0.65 1.94e-41 Caffeine consumption; LUSC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg05855489 chr10:104503620 C10orf26 0.58 9.29 0.45 2.07e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7582720 1.000 rs72926781 chr2:203808835 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9325144 0.624 rs10783333 chr12:39118931 A/T cg26384229 chr12:38710491 ALG10B 0.59 9.16 0.45 5.44e-18 Morning vs. evening chronotype; LUSC cis rs7917772 0.582 rs7906115 chr10:104327164 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6840360 0.615 rs2120098 chr4:152457180 T/A cg22705602 chr4:152727874 NA -0.32 -6.55 -0.34 2.19e-10 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg12963246 chr6:28129442 ZNF389 0.49 7.19 0.37 4.21e-12 Parkinson's disease; LUSC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC trans rs7618501 0.633 rs2883057 chr3:49998282 C/T cg21659725 chr3:3221576 CRBN 0.64 10.45 0.5 2.61e-22 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg06808227 chr14:105710500 BRF1 -0.68 -10.71 -0.51 3.34e-23 Mean platelet volume;Platelet distribution width; LUSC cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg25427524 chr10:38739819 LOC399744 -0.63 -11.31 -0.53 2.53e-25 Extrinsic epigenetic age acceleration; LUSC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg23985595 chr17:80112537 CCDC57 -0.3 -5.91 -0.31 8.55e-9 Life satisfaction; LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg10802521 chr3:52805072 NEK4 -0.56 -9.11 -0.45 7.82e-18 Bipolar disorder; LUSC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg23422044 chr7:1970798 MAD1L1 -0.53 -6.39 -0.33 5.65e-10 Bipolar disorder; LUSC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg03709012 chr19:19516395 GATAD2A -0.77 -11.95 -0.55 1.19e-27 Tonsillectomy; LUSC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.26 0.59 1.6e-32 Monocyte percentage of white cells; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg22166914 chr1:53195759 ZYG11B 0.57 9.31 0.45 1.81e-18 Monocyte count; LUSC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg18681998 chr4:17616180 MED28 0.89 16.64 0.67 1.07e-45 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg03289416 chr15:75166202 SCAMP2 0.45 7.06 0.36 9.73e-12 Breast cancer; LUSC cis rs9905704 0.918 rs186221 chr17:56695967 C/T cg12560992 chr17:57184187 TRIM37 0.55 7.87 0.4 5.02e-14 Testicular germ cell tumor; LUSC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg20503657 chr10:835505 NA 0.78 9.42 0.46 7.61e-19 Eosinophil percentage of granulocytes; LUSC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg06481639 chr22:41940642 POLR3H -0.52 -6.31 -0.33 8.83e-10 Vitiligo; LUSC cis rs7149337 0.836 rs11622116 chr14:51670744 C/T cg23942311 chr14:51606299 NA 0.48 10.53 0.5 1.39e-22 Cancer; LUSC cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg03146154 chr1:46216737 IPP 0.54 8.33 0.41 2.08e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg18876405 chr7:65276391 NA -0.54 -8.52 -0.42 5.68e-16 Aortic root size; LUSC cis rs1595825 0.891 rs892512 chr2:198905910 C/A cg00982548 chr2:198649783 BOLL -0.52 -6.86 -0.35 3.4e-11 Ulcerative colitis; LUSC cis rs9796 0.866 rs2928148 chr15:41401550 G/A cg18705301 chr15:41695430 NDUFAF1 0.46 8.04 0.4 1.55e-14 Menopause (age at onset); LUSC trans rs724744 0.772 rs1772081 chr6:22354351 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.19 -0.32 1.77e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7481584 0.624 rs80871 chr11:3049843 A/C cg05729581 chr11:3078854 CARS 0.39 5.7 0.3 2.57e-8 Calcium levels; LUSC trans rs459571 0.959 rs392134 chr9:136909008 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.79 -13.21 -0.59 2.49e-32 Platelet distribution width; LUSC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg16339924 chr4:17578868 LAP3 0.48 7.45 0.38 8.14e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.59 0.6 8.31e-34 Platelet count; LUSC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 6.14 0.32 2.39e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs11039100 0.527 rs11038945 chr11:5779431 A/G cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs11098499 0.532 rs4504231 chr4:120586891 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.1 0.32 2.97e-9 Corneal astigmatism; LUSC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg06221963 chr1:154839813 KCNN3 -0.6 -13.52 -0.59 1.57e-33 Prostate cancer; LUSC cis rs6489882 0.867 rs7304898 chr12:113365667 T/C cg20102336 chr12:113376681 OAS3 -0.42 -5.94 -0.31 7.04e-9 Chronic lymphocytic leukemia; LUSC cis rs6582630 0.555 rs8189479 chr12:38308240 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.98 -0.36 1.58e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg12311346 chr5:56204834 C5orf35 -0.9 -13.37 -0.59 6.19e-33 Initial pursuit acceleration; LUSC trans rs8023715 1.000 rs28674917 chr15:97612127 G/A cg09939392 chr16:90068365 NA 0.51 5.97 0.31 6.22e-9 Systemic lupus erythematosus; LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg15383120 chr6:291909 DUSP22 -0.43 -6.37 -0.33 6.11e-10 Menopause (age at onset); LUSC cis rs2204008 0.652 rs11513964 chr12:37998214 C/G cg13010199 chr12:38710504 ALG10B 0.7 10.86 0.51 9.62e-24 Bladder cancer; LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.3 -0.41 2.54e-15 Platelet count; LUSC cis rs654950 0.875 rs4660544 chr1:41996871 T/C cg06885757 chr1:42089581 HIVEP3 -0.34 -6.54 -0.34 2.26e-10 Airway imaging phenotypes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22456539 chr1:11741693 MAD2L2 -0.44 -6.49 -0.33 3.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7937682 0.632 rs4936800 chr11:111734097 T/A cg18187862 chr3:45730750 SACM1L -0.51 -6.17 -0.32 1.99e-9 Primary sclerosing cholangitis; LUSC cis rs12286929 0.590 rs4936322 chr11:115061533 T/C cg04055981 chr11:115044050 NA 0.45 7.91 0.4 3.93e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs61931739 0.500 rs11513287 chr12:34584351 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.32 0.64 1.71e-40 Morning vs. evening chronotype; LUSC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg20276088 chr3:133502917 NA -0.44 -6.49 -0.33 3.12e-10 Iron status biomarkers; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 6.3 0.33 9.39e-10 Electroencephalogram traits; LUSC cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg16797656 chr11:68205561 LRP5 0.38 6.27 0.32 1.09e-9 Total body bone mineral density; LUSC cis rs7789940 1.000 rs7789940 chr7:75951230 A/G cg10167463 chr7:75959203 YWHAG -0.64 -9.63 -0.47 1.58e-19 Multiple sclerosis; LUSC cis rs2760061 0.583 rs708110 chr1:228190805 T/A cg01973587 chr1:228161476 NA -0.35 -5.66 -0.3 3.34e-8 Diastolic blood pressure; LUSC trans rs7824557 0.707 rs3808519 chr8:11142970 C/G cg15556689 chr8:8085844 FLJ10661 0.56 8.88 0.44 4.12e-17 Retinal vascular caliber; LUSC cis rs11098499 0.775 rs10021601 chr4:120282563 G/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs6554196 0.508 rs981959 chr4:55526962 G/T cg18836493 chr4:55524333 KIT -0.44 -7.47 -0.38 7.08e-13 Monocyte count; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg03934478 chr11:495069 RNH1 0.86 10.29 0.49 9.41e-22 Body mass index; LUSC trans rs853679 0.882 rs9366717 chr6:28191057 C/T cg06606381 chr12:133084897 FBRSL1 -0.66 -6.94 -0.36 2.05e-11 Depression; LUSC cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg24130564 chr14:104152367 KLC1 -0.43 -6.11 -0.32 2.71e-9 Body mass index; LUSC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg19318889 chr4:1322082 MAEA 0.59 10.36 0.49 5.24e-22 Longevity; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.61 0.57 4.22e-30 Prudent dietary pattern; LUSC cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg12011299 chr4:100065546 ADH4 -0.73 -10.9 -0.51 7.15e-24 Alcohol dependence; LUSC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg04025307 chr7:1156635 C7orf50 0.42 5.87 0.31 1.06e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7824557 0.628 rs11991153 chr8:11203107 A/T cg15556689 chr8:8085844 FLJ10661 0.48 7.05 0.36 1.06e-11 Retinal vascular caliber; LUSC trans rs3824451 0.945 rs7869364 chr9:101065212 G/T cg02729030 chr7:110879415 IMMP2L -0.47 -6.64 -0.34 1.3e-10 Schizophrenia; LUSC cis rs8062405 0.964 rs78613234 chr16:28839425 T/C cg09754948 chr16:28834200 ATXN2L 0.43 6.35 0.33 7.17e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg21361702 chr7:150065534 REPIN1 0.52 6.68 0.34 1.03e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg18225595 chr11:63971243 STIP1 0.51 6.31 0.33 8.81e-10 Mean platelet volume; LUSC trans rs7615952 0.673 rs3811677 chr3:125648080 G/A cg07211511 chr3:129823064 LOC729375 -1.25 -20.35 -0.74 1.98e-60 Blood pressure (smoking interaction); LUSC cis rs662064 0.962 rs585870 chr1:10549628 G/T cg20482658 chr1:10539492 PEX14 -0.32 -6.64 -0.34 1.29e-10 Asthma; LUSC trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -7.92 -0.4 3.45e-14 Triglycerides; LUSC cis rs2486288 0.656 rs12910009 chr15:45572408 A/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.77 -0.39 9.67e-14 Glomerular filtration rate; LUSC cis rs1801251 0.835 rs1446310 chr2:233683245 G/C cg08000102 chr2:233561755 GIGYF2 -0.67 -10.96 -0.51 4.38e-24 Coronary artery disease; LUSC cis rs7771547 0.519 rs9654588 chr6:36363923 A/C cg07856975 chr6:36356162 ETV7 0.43 6.17 0.32 1.93e-9 Platelet distribution width; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.17 0.55 1.94e-28 Prudent dietary pattern; LUSC cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg22782873 chr19:19639568 YJEFN3 -0.48 -6.1 -0.32 2.86e-9 Bipolar disorder; LUSC cis rs2729354 0.768 rs2581922 chr11:57265400 C/T cg24343310 chr11:57249947 NA 0.38 7.3 0.37 2.16e-12 Blood protein levels; LUSC cis rs16937 0.711 rs11240385 chr1:205173101 A/G cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs6964587 1.000 rs6465343 chr7:91618208 T/C cg17063962 chr7:91808500 NA 0.56 8.97 0.44 2.2e-17 Breast cancer; LUSC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg11752832 chr7:134001865 SLC35B4 0.59 9.3 0.45 1.94e-18 Mean platelet volume; LUSC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg22467129 chr15:76604101 ETFA -0.43 -6.9 -0.35 2.69e-11 Blood metabolite levels; LUSC cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg23711669 chr6:146136114 FBXO30 -0.83 -14.87 -0.63 9.93e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg26587870 chr6:27730563 NA -0.66 -6.01 -0.31 4.92e-9 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; LUSC cis rs73206853 0.841 rs111612251 chr12:111017607 T/C cg12870014 chr12:110450643 ANKRD13A 0.69 7.57 0.38 3.57e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs11088226 0.541 rs75873023 chr21:33910658 G/A cg09050820 chr6:167586206 TCP10L2 0.43 5.99 0.31 5.45e-9 Gastritis; LUSC trans rs9650657 0.537 rs11250092 chr8:10786543 A/G cg06636001 chr8:8085503 FLJ10661 0.53 7.84 0.39 5.98e-14 Neuroticism; LUSC cis rs11122272 0.706 rs2749710 chr1:231535112 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.66 10.36 0.49 5.54e-22 Hemoglobin concentration; LUSC cis rs983392 0.868 rs7926954 chr11:59932579 G/A cg20284999 chr11:59952153 MS4A6A -0.37 -5.98 -0.31 5.8e-9 Alzheimer's disease (late onset); LUSC cis rs6489882 0.836 rs6489878 chr12:113368125 A/G cg20102336 chr12:113376681 OAS3 -0.4 -5.74 -0.3 2.17e-8 Chronic lymphocytic leukemia; LUSC cis rs7927771 0.524 rs10838777 chr11:47860954 A/C cg20307385 chr11:47447363 PSMC3 0.46 6.72 0.34 8.08e-11 Subjective well-being; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg02475777 chr4:1388615 CRIPAK 0.44 6.62 0.34 1.42e-10 Obesity-related traits; LUSC cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg12011299 chr4:100065546 ADH4 0.73 12.04 0.55 5.8e-28 Alcohol dependence; LUSC cis rs113835537 0.935 rs15969 chr11:66394387 C/T cg24851651 chr11:66362959 CCS 0.53 6.55 0.34 2.14e-10 Airway imaging phenotypes; LUSC cis rs6138458 1.000 rs4273288 chr20:24900873 G/A cg26195577 chr20:24973756 C20orf3 -1.12 -18.25 -0.71 4.21e-52 Blood protein levels; LUSC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg13628971 chr7:2884303 GNA12 0.39 5.68 0.3 2.94e-8 Height; LUSC cis rs7568458 0.660 rs6722691 chr2:85758352 C/T cg02493740 chr2:85810744 VAMP5 -0.49 -8.43 -0.42 1.04e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg18357526 chr6:26021779 HIST1H4A 0.37 5.67 0.3 3.04e-8 Intelligence (multi-trait analysis); LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg13685833 chr1:53393034 SCP2 0.45 6.63 0.34 1.38e-10 Monocyte count; LUSC trans rs1005277 0.522 rs11011343 chr10:38002698 A/G cg17830980 chr10:43048298 ZNF37B -0.41 -6.56 -0.34 2.07e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg20243544 chr17:37824526 PNMT 0.38 5.72 0.3 2.42e-8 Self-reported allergy; LUSC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.43 -6.36 -0.33 6.75e-10 Colorectal cancer; LUSC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg17279839 chr7:150038598 RARRES2 0.48 7.64 0.39 2.35e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs11051970 0.636 rs10844198 chr12:32563479 G/T cg02745156 chr12:32552066 NA 0.37 6.82 0.35 4.3e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9811920 0.625 rs9290003 chr3:99906993 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.34 6.35 0.33 7.07e-10 Axial length; LUSC cis rs992157 1.000 rs992157 chr2:219154781 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.49 -7.82 -0.39 7.05e-14 Colorectal cancer; LUSC cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg12011299 chr4:100065546 ADH4 -0.71 -11.17 -0.52 7.69e-25 Alcohol dependence; LUSC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg08847533 chr14:75593920 NEK9 -0.82 -15.16 -0.64 7.45e-40 Height; LUSC cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg11266682 chr4:10021025 SLC2A9 0.58 10.73 0.51 2.73e-23 Bone mineral density; LUSC cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg08999081 chr20:33150536 PIGU 0.43 7.95 0.4 2.96e-14 Coronary artery disease; LUSC cis rs2795502 1.000 rs2795496 chr10:43337842 G/A cg20628663 chr10:43360327 NA -0.75 -11.33 -0.53 2.21e-25 Blood protein levels; LUSC cis rs7106204 1.000 rs7925633 chr11:24214815 A/G ch.11.24196551F chr11:24239977 NA 0.99 9.81 0.47 4.07e-20 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7605827 0.836 rs13009246 chr2:15640237 A/G cg19274914 chr2:15703543 NA 0.46 8.79 0.43 8.17e-17 Educational attainment (years of education); LUSC cis rs6546550 0.901 rs897119 chr2:70160658 T/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.22e-12 Prevalent atrial fibrillation; LUSC cis rs7523050 0.643 rs34920128 chr1:109400889 C/T cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs9879311 0.966 rs4684685 chr3:10411553 C/T cg11030744 chr3:10328490 GHRL;GHRLOS 0.48 8.03 0.4 1.66e-14 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs6722750 0.716 rs2422116 chr2:64420236 C/T cg22352474 chr2:64371530 PELI1 -0.54 -8.05 -0.4 1.43e-14 Neuroticism; LUSC cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg24596788 chr1:163392923 NA 0.45 7.59 0.38 3.24e-13 Motion sickness; LUSC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs68170813 0.559 rs6951639 chr7:106817639 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.7 -0.47 9.21e-20 Coronary artery disease; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs35110281 0.805 rs162402 chr21:44963418 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.88 0.48 2.23e-20 Mean corpuscular volume; LUSC cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg23711669 chr6:146136114 FBXO30 0.72 12.38 0.56 3.21e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs2806561 0.765 rs641032 chr1:23513980 C/T cg12483005 chr1:23474871 LUZP1 -0.43 -6.82 -0.35 4.23e-11 Height; LUSC cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg17366294 chr4:99064904 C4orf37 0.52 9.14 0.45 6.41e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg03806693 chr22:41940476 POLR3H 0.99 14.23 0.61 3.13e-36 Vitiligo; LUSC cis rs10435719 0.902 rs11250179 chr8:11800332 C/T cg21775007 chr8:11205619 TDH 0.45 6.37 0.33 6.18e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg15704280 chr7:45808275 SEPT13 0.75 8.53 0.42 5.3e-16 Axial length; LUSC cis rs73129298 0.551 rs1063210 chr20:48600809 G/A cg25655593 chr20:48599521 SNAI1 0.6 6.43 0.33 4.49e-10 Inflammatory skin disease; LUSC cis rs34779708 0.966 rs11010135 chr10:35518063 A/G cg04310649 chr10:35416472 CREM -0.4 -6.14 -0.32 2.37e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7336332 0.800 rs9805452 chr13:28047908 C/T cg22138327 chr13:27999177 GTF3A 0.68 9.27 0.45 2.35e-18 Weight; LUSC cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg02527881 chr3:46936655 PTH1R 0.41 7.16 0.36 5.19e-12 Colorectal cancer; LUSC cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.38 0.33 6.05e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg03146154 chr1:46216737 IPP 0.55 8.24 0.41 3.98e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7712401 0.601 rs454617 chr5:122321927 A/C cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs16895831 0.531 rs56302029 chr6:42522409 T/G cg10605015 chr6:42532144 UBR2 -0.52 -6.27 -0.32 1.11e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg25204440 chr1:209979598 IRF6 0.53 7.08 0.36 8.6e-12 Cleft lip with or without cleft palate; LUSC trans rs2898290 0.694 rs2248909 chr8:11392093 A/C cg06636001 chr8:8085503 FLJ10661 -0.57 -8.89 -0.44 3.9e-17 Systolic blood pressure; LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg03188948 chr7:1209495 NA 0.66 6.91 0.35 2.44e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs977987 0.806 rs2865530 chr16:75414376 G/T cg03315344 chr16:75512273 CHST6 0.49 9.25 0.45 2.65e-18 Dupuytren's disease; LUSC cis rs9815354 0.812 rs73071330 chr3:41810553 T/G cg03022575 chr3:42003672 ULK4 0.85 8.65 0.43 2.27e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs708547 0.647 rs4864609 chr4:57878141 T/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.64 0.39 2.31e-13 Response to bleomycin (chromatid breaks); LUSC trans rs7824557 0.606 rs2736270 chr8:11192593 G/A cg08975724 chr8:8085496 FLJ10661 0.48 6.86 0.35 3.42e-11 Retinal vascular caliber; LUSC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg25282410 chr6:160211355 TCP1;MRPL18 1.04 15.13 0.64 9.12e-40 Age-related macular degeneration (geographic atrophy); LUSC cis rs881375 0.678 rs10739581 chr9:123696871 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.86 0.31 1.13e-8 Rheumatoid arthritis; LUSC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg03806693 chr22:41940476 POLR3H 0.94 13.86 0.6 8.14e-35 Vitiligo; LUSC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg24675658 chr1:53192096 ZYG11B -0.64 -9.92 -0.48 1.65e-20 Monocyte count; LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.52 8.34 0.41 2.04e-15 Bipolar disorder; LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.54 -8.15 -0.41 7.46e-15 Lymphocyte counts; LUSC cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg09184832 chr6:79620586 NA -0.45 -7.28 -0.37 2.44e-12 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg19774624 chr17:42201019 HDAC5 0.8 12.66 0.57 2.76e-30 Total body bone mineral density; LUSC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg24209194 chr3:40518798 ZNF619 0.43 5.85 0.3 1.16e-8 Renal cell carcinoma; LUSC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg04155289 chr7:94953770 PON1 -0.36 -5.95 -0.31 6.86e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1728785 1.000 rs1094282 chr16:68577260 G/A cg02508848 chr16:68573721 ZFP90 -0.42 -5.75 -0.3 2.07e-8 Ulcerative colitis; LUSC cis rs2625529 0.556 rs55679065 chr15:72433395 C/T cg16672083 chr15:72433130 SENP8 0.5 8.34 0.42 1.97e-15 Red blood cell count; LUSC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg02117656 chr17:79614917 TSPAN10 -0.32 -5.86 -0.31 1.11e-8 Eye color traits; LUSC cis rs1065852 0.526 rs9623489 chr22:42397026 A/G cg22189786 chr22:42395067 WBP2NL 0.43 5.74 0.3 2.13e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.52 -0.34 2.58e-10 Lung cancer; LUSC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg21028142 chr17:79581711 NPLOC4 0.32 7.61 0.38 2.91e-13 Eye color traits; LUSC cis rs1865760 1.000 rs2071299 chr6:25914801 G/A cg16482183 chr6:26056742 HIST1H1C 0.44 6.46 0.33 3.77e-10 Height; LUSC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg22800045 chr5:56110881 MAP3K1 0.46 6.65 0.34 1.21e-10 Coronary artery disease; LUSC cis rs6084875 0.840 rs2104143 chr20:4723157 G/A cg26097573 chr20:4721490 PRNT -0.31 -5.76 -0.3 1.87e-8 Systemic lupus erythematosus; LUSC cis rs11098499 0.754 rs12506610 chr4:120241659 T/C cg09307838 chr4:120376055 NA 0.69 10.49 0.5 1.93e-22 Corneal astigmatism; LUSC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11644478 chr21:40555479 PSMG1 -0.61 -9.46 -0.46 5.55e-19 Menarche (age at onset); LUSC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg06634786 chr22:41940651 POLR3H -0.57 -6.44 -0.33 4.11e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs6502050 0.749 rs7406163 chr17:80086389 C/T cg07393940 chr7:158741817 NA -0.38 -6.83 -0.35 4.02e-11 Life satisfaction; LUSC cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg08807101 chr21:30365312 RNF160 -0.76 -14.1 -0.61 9.79e-36 Dental caries; LUSC cis rs7523050 0.643 rs7522324 chr1:109399644 T/C cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg18404041 chr3:52824283 ITIH1 -0.63 -11.65 -0.54 1.45e-26 Bipolar disorder; LUSC cis rs7264396 0.623 rs2425127 chr20:34332037 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.23 -0.41 4.21e-15 Total cholesterol levels; LUSC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg24110177 chr3:50126178 RBM5 0.66 11.3 0.53 2.71e-25 Body mass index; LUSC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg03806693 chr22:41940476 POLR3H -1.05 -14.81 -0.63 1.65e-38 Vitiligo; LUSC cis rs6433857 0.536 rs4625864 chr2:181353942 G/C cg23363182 chr2:181467187 NA -0.45 -7.27 -0.37 2.58e-12 Body mass index; LUSC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg20135002 chr11:47629003 NA -0.5 -7.82 -0.39 7.01e-14 Subjective well-being; LUSC cis rs17001868 0.527 rs11913132 chr22:40778778 A/G cg07138101 chr22:40742427 ADSL 0.56 6.87 0.35 3.06e-11 Mammographic density (dense area); LUSC cis rs9788682 0.747 rs11637630 chr15:78899719 G/A cg06917634 chr15:78832804 PSMA4 0.51 6.49 0.33 3.03e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg03806693 chr22:41940476 POLR3H 0.99 13.72 0.6 2.7200000000000002e-34 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.61 -0.5 7.2e-23 Chronic sinus infection; LUSC cis rs12210905 0.688 rs12212389 chr6:27326397 T/C cg08851530 chr6:28072375 NA 0.9 5.78 0.3 1.75e-8 Hip circumference adjusted for BMI; LUSC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg27494647 chr7:150038898 RARRES2 0.59 8.73 0.43 1.2e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg08499158 chr17:42289980 UBTF -0.52 -8.65 -0.43 2.18e-16 Total body bone mineral density; LUSC cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg11584989 chr19:19387371 SF4 0.66 7.85 0.39 5.57e-14 Bipolar disorder; LUSC cis rs992157 0.735 rs12990082 chr2:219102332 C/T cg00012203 chr2:219082015 ARPC2 0.9 17.41 0.69 9.53e-49 Colorectal cancer; LUSC cis rs3764563 0.660 rs8107923 chr19:15737899 A/T cg20725493 chr19:15740067 CYP4F8 -0.64 -6.61 -0.34 1.53e-10 Inflammatory biomarkers; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg27535305 chr1:53392650 SCP2 0.36 6.8 0.35 4.92e-11 Monocyte count; LUSC cis rs11122272 0.701 rs11582413 chr1:231530098 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.25 -0.49 1.28e-21 Hemoglobin concentration; LUSC cis rs1865760 0.713 rs7766342 chr6:25990674 C/A cg16482183 chr6:26056742 HIST1H1C 0.47 6.88 0.35 2.95e-11 Height; LUSC cis rs7799006 0.606 rs34417375 chr7:2315105 C/T cg02951883 chr7:2050386 MAD1L1 -0.36 -5.91 -0.31 8.5e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9469578 0.710 rs77213792 chr6:33713952 C/G cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs2948294 0.545 rs11776397 chr8:8115161 C/T cg08975724 chr8:8085496 FLJ10661 0.55 7.17 0.37 4.9e-12 Red cell distribution width; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01745690 chr7:43798100 BLVRA -0.4 -5.98 -0.31 5.59e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs782590 0.517 rs13013133 chr2:55889466 G/A cg18811423 chr2:55921094 PNPT1 -0.62 -8.4 -0.42 1.29e-15 Metabolic syndrome; LUSC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg01448562 chr3:133502909 NA -0.69 -11.68 -0.54 1.2e-26 Iron status biomarkers; LUSC trans rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.91 0.35 2.53e-11 Endometrial cancer; LUSC cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg09184832 chr6:79620586 NA -0.45 -7.3 -0.37 2.18e-12 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg19230755 chr7:65878503 NA -0.42 -6.01 -0.31 4.89e-9 Aortic root size; LUSC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs13064411 0.735 rs7631138 chr3:113231925 A/T cg18753928 chr3:113234510 CCDC52 -0.51 -7.92 -0.4 3.48e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg09491104 chr22:46646882 C22orf40 -0.66 -8.76 -0.43 1.01e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs9462027 0.562 rs2814946 chr6:34651180 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.29 -0.33 1.01e-9 Systemic lupus erythematosus; LUSC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg16405210 chr4:1374714 KIAA1530 -0.61 -9.53 -0.46 3.36e-19 Obesity-related traits; LUSC cis rs1451375 0.794 rs11238134 chr7:50542927 A/C cg18232548 chr7:50535776 DDC -0.54 -8.3 -0.41 2.69e-15 Malaria; LUSC trans rs11992162 0.967 rs10088415 chr8:11830825 A/G cg27411982 chr8:10470053 RP1L1 -0.5 -7.85 -0.39 5.81e-14 Monocyte count; LUSC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7122539 0.646 rs569818 chr11:66570749 G/A cg18002602 chr11:66138449 SLC29A2 -0.35 -6.27 -0.32 1.14e-9 HIV-1 susceptibility; LUSC cis rs72772090 1.000 rs72772095 chr5:96053853 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.67 -7.49 -0.38 6.07e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs911555 0.755 rs8014800 chr14:103946302 T/C cg17675199 chr6:35436792 RPL10A -0.43 -6.32 -0.33 8.21e-10 Intelligence (multi-trait analysis); LUSC cis rs4478858 0.647 rs10798836 chr1:31709214 C/T cg00250761 chr1:31883323 NA -0.34 -8.09 -0.4 1.1e-14 Alcohol dependence; LUSC cis rs1568889 1.000 rs11603799 chr11:28196488 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.3 0.45 1.95e-18 Bipolar disorder; LUSC cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg24130564 chr14:104152367 KLC1 -0.47 -6.87 -0.35 3.12e-11 Intelligence (multi-trait analysis); LUSC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg02951883 chr7:2050386 MAD1L1 -0.53 -9.33 -0.45 1.49e-18 Schizophrenia; LUSC cis rs6066835 1.000 rs6066832 chr20:47354132 C/A cg18078177 chr20:47281410 PREX1 0.71 6.21 0.32 1.61e-9 Multiple myeloma; LUSC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg11764359 chr7:65958608 NA -0.51 -6.57 -0.34 1.94e-10 Aortic root size; LUSC cis rs2239547 0.563 rs4687699 chr3:53101224 C/T cg18404041 chr3:52824283 ITIH1 -0.54 -9.31 -0.45 1.78e-18 Schizophrenia; LUSC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg23283495 chr1:209979779 IRF6 0.71 9.41 0.46 8.49e-19 Cleft lip with or without cleft palate; LUSC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg16928487 chr17:17741425 SREBF1 0.48 9.61 0.47 1.8e-19 Total body bone mineral density; LUSC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg21951975 chr1:209979733 IRF6 -0.53 -6.7 -0.34 9e-11 Cleft lip with or without cleft palate; LUSC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05985164 chr12:57881757 MARS -0.52 -6.46 -0.33 3.77e-10 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7833986 0.501 rs2719233 chr8:56886156 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.67 10.31 0.49 8.15e-22 Height; LUSC cis rs7917772 0.628 rs4604806 chr10:104373904 G/A cg05855489 chr10:104503620 C10orf26 -0.48 -7.35 -0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs2048656 0.605 rs7814507 chr8:9646560 G/A cg15556689 chr8:8085844 FLJ10661 0.46 6.47 0.33 3.55e-10 Schizophrenia; LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg20295408 chr7:1910781 MAD1L1 -0.42 -5.9 -0.31 8.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.529 rs6060296 chr20:30198480 T/C cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.2e-10 Mean corpuscular hemoglobin; LUSC cis rs2299587 0.531 rs28839855 chr8:17855983 T/C cg01800426 chr8:17659068 MTUS1 -0.52 -6.67 -0.34 1.09e-10 Economic and political preferences; LUSC cis rs7100689 0.784 rs10749578 chr10:82139115 A/G cg00277334 chr10:82204260 NA 0.49 6.71 0.34 8.14e-11 Post bronchodilator FEV1; LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg21782813 chr7:2030301 MAD1L1 0.38 6.22 0.32 1.5e-9 Bipolar disorder and schizophrenia; LUSC cis rs10782582 0.593 rs11802717 chr1:76124648 C/T cg03433033 chr1:76189801 ACADM -0.45 -6.84 -0.35 3.86e-11 Daytime sleep phenotypes; LUSC cis rs13236689 0.516 rs1334512 chr7:80267904 G/T cg04458919 chr7:80252533 CD36 -0.39 -6.65 -0.34 1.23e-10 Mean platelet volume; LUSC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg23172400 chr8:95962367 TP53INP1 -0.33 -6.76 -0.35 6.24e-11 Type 2 diabetes; LUSC trans rs7613875 0.620 rs3774734 chr3:50108792 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -7.86 -0.4 5.2e-14 Body mass index; LUSC cis rs9359856 0.510 rs17293240 chr6:90396370 C/T cg13799429 chr6:90582589 CASP8AP2 0.91 10.86 0.51 9.72e-24 Bipolar disorder; LUSC cis rs765787 0.530 rs2458224 chr15:45522130 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.82 -0.43 6.24e-17 Uric acid levels; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg17178900 chr1:205818956 PM20D1 0.8 13.48 0.59 2.24e-33 Menarche (age at onset); LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.12 -0.36 6.7e-12 Menopause (age at onset); LUSC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg09367891 chr1:107599246 PRMT6 0.53 8.11 0.41 1.01e-14 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg13453750 chr1:205783389 SLC41A1 -0.32 -6.45 -0.33 3.83e-10 Menarche (age at onset); LUSC cis rs7615952 0.800 rs35390120 chr3:125599809 G/A cg05084668 chr3:125655381 ALG1L -0.83 -11.71 -0.54 9.28e-27 Blood pressure (smoking interaction); LUSC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg25251562 chr2:3704773 ALLC -0.49 -7.43 -0.38 9.3e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg17554472 chr22:41940697 POLR3H -0.47 -5.76 -0.3 1.91e-8 Vitiligo; LUSC cis rs394563 0.967 rs447025 chr6:149799128 A/C cg03678062 chr6:149772716 ZC3H12D -0.31 -6.41 -0.33 4.86e-10 Dupuytren's disease; LUSC cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg22681709 chr2:178499509 PDE11A -0.51 -8.94 -0.44 2.61e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2439831 1.000 rs690316 chr15:43737880 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.84 0.44 5.72e-17 Lung cancer in ever smokers; LUSC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.99 -0.31 5.53e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg20503657 chr10:835505 NA 0.99 14.13 0.61 7.27e-36 Eosinophil percentage of granulocytes; LUSC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg01017244 chr2:74357527 NA 0.73 14.1 0.61 9.17e-36 Gestational age at birth (maternal effect); LUSC cis rs911119 0.657 rs6114214 chr20:23627924 A/T cg16589663 chr20:23618590 CST3 0.55 5.99 0.31 5.37e-9 Chronic kidney disease; LUSC cis rs4409675 0.576 rs12062621 chr1:28230404 A/G cg23691781 chr1:28212827 C1orf38 0.31 7.48 0.38 6.53e-13 Corneal astigmatism; LUSC trans rs853679 0.517 rs6922063 chr6:28094366 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.11 -0.32 2.83e-9 Depression; LUSC trans rs10411161 0.702 rs6509592 chr19:52393150 G/A cg22319618 chr22:45562946 NUP50 -0.52 -6.12 -0.32 2.64e-9 Breast cancer; LUSC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg03388025 chr16:89894329 SPIRE2 0.3 6.31 0.33 8.74e-10 Vitiligo; LUSC cis rs9467773 0.967 rs9358954 chr6:26531178 A/G cg09904177 chr6:26538194 HMGN4 0.76 14.41 0.62 5.82e-37 Intelligence (multi-trait analysis); LUSC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.59 9.29 0.45 2.04e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs2580764 0.515 rs4672005 chr2:55246551 C/T cg09592903 chr2:55203963 RTN4 -0.49 -10.1 -0.48 4.34e-21 Mean platelet volume; LUSC cis rs9818941 0.824 rs11707532 chr3:157801867 T/C cg08654915 chr3:157813417 NA 0.33 7.76 0.39 1.06e-13 Height; LUSC cis rs3816788 0.774 rs11784816 chr8:21773500 C/T cg17168535 chr8:21777572 XPO7 -0.69 -11.83 -0.54 3.28e-27 Lung cancer in ever smokers; LUSC cis rs477692 1.000 rs580745 chr10:131414401 G/A cg26102564 chr10:131424627 MGMT 0.4 6.24 0.32 1.34e-9 Response to temozolomide; LUSC cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg23649088 chr2:200775458 C2orf69 0.56 8.27 0.41 3.25e-15 Schizophrenia; LUSC cis rs7020830 0.823 rs13285624 chr9:37129496 T/G cg14294708 chr9:37120828 ZCCHC7 1.11 25.84 0.82 1.22e-81 Schizophrenia; LUSC cis rs5769765 0.657 rs8136116 chr22:50256886 T/A cg02269571 chr22:50332266 NA 0.59 7.57 0.38 3.67e-13 Schizophrenia; LUSC cis rs7195287 0.826 rs9925824 chr16:2827973 C/T cg05687563 chr16:2837658 PRSS33 -0.33 -6.21 -0.32 1.53e-9 Eosinophil counts; LUSC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs9300255 0.722 rs10846515 chr12:123801672 T/G cg13010344 chr12:123464640 ARL6IP4 -0.5 -6.42 -0.33 4.76e-10 Neutrophil percentage of white cells; LUSC trans rs10511400 0.618 rs9842302 chr3:119918358 C/T cg02809009 chr19:50354510 PTOV1 -0.7 -6.21 -0.32 1.54e-9 Economic and political preferences (feminism/equality); LUSC cis rs7647973 0.626 rs9829155 chr3:49817450 T/C cg13072238 chr3:49761600 GMPPB 0.65 8.33 0.41 2.14e-15 Menarche (age at onset); LUSC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg22920501 chr2:26401640 FAM59B -0.73 -10.59 -0.5 8.37e-23 Gut microbiome composition (summer); LUSC cis rs4629180 0.675 rs908132 chr2:102093096 A/G cg04415270 chr2:102091202 RFX8 -0.46 -7.91 -0.4 3.88e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs1865760 0.663 rs9379815 chr6:25980116 T/A cg17691542 chr6:26056736 HIST1H1C 0.44 6.7 0.34 9.04e-11 Height; LUSC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg09796270 chr17:17721594 SREBF1 0.43 7.55 0.38 4.29e-13 Total body bone mineral density; LUSC cis rs7793919 0.652 rs10228886 chr7:4783224 C/T cg09789173 chr7:4769017 FOXK1 -0.55 -10.27 -0.49 1.14e-21 Mosquito bite size; LUSC cis rs6582630 0.560 rs4882325 chr12:38510037 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.67 -0.43 1.95e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg10802521 chr3:52805072 NEK4 0.55 8.81 0.43 6.93e-17 Bipolar disorder; LUSC trans rs7829975 0.688 rs7826660 chr8:8379107 C/A cg21775007 chr8:11205619 TDH 0.45 6.63 0.34 1.34e-10 Mood instability; LUSC cis rs1371867 0.846 rs1660328 chr8:101303450 A/G cg06002616 chr8:101225028 SPAG1 -0.41 -6.93 -0.35 2.21e-11 Atrioventricular conduction; LUSC cis rs6847149 0.929 rs10857002 chr4:110773433 A/C cg07850274 chr4:110748770 RRH 0.53 7.57 0.38 3.73e-13 Exercise treadmill test traits; LUSC cis rs983392 0.680 rs56357056 chr11:59986817 A/G cg02771260 chr11:59836817 MS4A3 -0.36 -5.91 -0.31 8.58e-9 Alzheimer's disease (late onset); LUSC cis rs17102423 0.755 rs12880781 chr14:65576257 C/T cg11161011 chr14:65562177 MAX -0.81 -12.26 -0.56 8.99e-29 Obesity-related traits; LUSC cis rs2749592 0.918 rs11011388 chr10:38155210 C/T cg25427524 chr10:38739819 LOC399744 0.54 7.63 0.39 2.55e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs11098499 0.754 rs12513083 chr4:120249612 A/T cg25214090 chr10:38739885 LOC399744 0.43 6.47 0.33 3.54e-10 Corneal astigmatism; LUSC trans rs8072100 0.701 rs8078309 chr17:45774072 T/C cg04995722 chr7:26192034 NFE2L3 -0.42 -6.44 -0.33 4.15e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg07636037 chr3:49044803 WDR6 1.03 17.98 0.7 5.14e-51 Parkinson's disease; LUSC cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg04586622 chr2:25135609 ADCY3 0.42 8.99 0.44 1.88e-17 Body mass index; LUSC cis rs4805272 0.539 rs7256211 chr19:29333063 C/G cg12667521 chr19:29218732 NA 0.51 6.21 0.32 1.54e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9434723 0.844 rs9434729 chr1:9303940 G/C cg04199779 chr1:9294473 H6PD 0.49 5.75 0.3 2.02e-8 Height; LUSC cis rs7917772 0.582 rs12411442 chr10:104349531 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.94 0.51 5.25e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg24531977 chr5:56204891 C5orf35 0.53 7.87 0.4 4.93e-14 Coronary artery disease; LUSC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg18230493 chr5:56204884 C5orf35 -0.87 -12.96 -0.58 2.16e-31 Initial pursuit acceleration; LUSC cis rs4663866 1.000 rs13026475 chr2:239178455 T/C cg16914508 chr2:239161102 PER2 0.68 7.15 0.36 5.4e-12 Irritable bowel syndrome; LUSC cis rs8078723 0.668 rs3859192 chr17:38128648 C/T cg17467752 chr17:38218738 THRA 0.53 7.82 0.39 7.13e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7119 0.717 rs34194537 chr15:77795761 G/A cg27398640 chr15:77910606 LINGO1 -0.28 -5.75 -0.3 1.99e-8 Type 2 diabetes; LUSC trans rs6601327 0.571 rs7820675 chr8:9647748 C/G cg15556689 chr8:8085844 FLJ10661 0.48 7.11 0.36 7.28e-12 Multiple myeloma (hyperdiploidy); LUSC cis rs9473147 0.516 rs9463342 chr6:47585106 A/T cg02130027 chr6:47444894 CD2AP 0.36 5.76 0.3 1.86e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.07 0.32 3.45e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs748404 0.723 rs565658 chr15:43556307 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.53 0.42 5.2e-16 Lung cancer; LUSC cis rs4654899 0.865 rs6426658 chr1:21361176 G/A cg01072550 chr1:21505969 NA -0.52 -7.64 -0.39 2.39e-13 Superior frontal gyrus grey matter volume; LUSC cis rs2115536 1.000 rs7163338 chr15:80198408 C/G cg00225070 chr15:80189496 MTHFS 0.61 9.41 0.46 8.01e-19 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7267979 1.000 rs6050561 chr20:25334855 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.03 -0.74 3.45e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6696846 0.791 rs11240352 chr1:205051711 C/G cg21545522 chr1:205238299 TMCC2 -0.45 -8.33 -0.41 2.18e-15 Red blood cell count; LUSC trans rs1486139 0.935 rs10263960 chr7:46287653 T/C cg17534202 chr9:96721102 NA -0.37 -6.53 -0.34 2.47e-10 Select biomarker traits; LUSC cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg09455208 chr3:40491958 NA 0.55 10.24 0.49 1.36e-21 Renal cell carcinoma; LUSC cis rs2760061 0.583 rs708124 chr1:228220771 A/T cg04850211 chr1:228464232 OBSCN -0.34 -5.97 -0.31 6.2e-9 Diastolic blood pressure; LUSC cis rs782590 0.902 rs782600 chr2:55848040 T/C cg03859395 chr2:55845619 SMEK2 0.81 14.82 0.63 1.47e-38 Metabolic syndrome; LUSC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg18876405 chr7:65276391 NA -0.58 -9.31 -0.45 1.8e-18 Aortic root size; LUSC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs950169 0.840 rs72748702 chr15:84915246 A/G cg17173187 chr15:85201210 NMB 0.37 6.65 0.34 1.19e-10 Schizophrenia; LUSC cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.18 0.45 4.54e-18 Motion sickness; LUSC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.77e-16 Aortic root size; LUSC cis rs7000551 0.725 rs4871998 chr8:22308150 A/T cg12081754 chr8:22256438 SLC39A14 0.52 8.34 0.41 2.04e-15 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.3 -0.45 1.93e-18 Extrinsic epigenetic age acceleration; LUSC cis rs1728785 1.000 rs698716 chr16:68560296 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.8 -0.3 1.52e-8 Ulcerative colitis; LUSC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6050267 0.556 rs62217177 chr20:25012178 A/G cg26195577 chr20:24973756 C20orf3 0.65 6.4 0.33 5.21e-10 Cognitive performance; LUSC cis rs208520 0.837 rs208471 chr6:66916749 A/C cg07460842 chr6:66804631 NA -1.01 -14.4 -0.62 6.88e-37 Exhaled nitric oxide output; LUSC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg05340658 chr4:99064831 C4orf37 0.65 11.08 0.52 1.65e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs561341 0.941 rs4795664 chr17:30233467 C/T cg27661571 chr11:113659931 NA -0.59 -6.5 -0.34 2.92e-10 Hip circumference adjusted for BMI; LUSC cis rs9549367 0.789 rs9549718 chr13:113909822 A/G cg18105134 chr13:113819100 PROZ -0.67 -9.48 -0.46 5.01e-19 Platelet distribution width; LUSC cis rs8014204 0.836 rs888413 chr14:75267396 C/T cg06637938 chr14:75390232 RPS6KL1 0.63 10.13 0.48 3.28e-21 Caffeine consumption; LUSC cis rs4561483 0.801 rs33637 chr16:11989875 A/T cg08843971 chr16:11963173 GSPT1 -0.47 -6.99 -0.36 1.53e-11 Testicular germ cell tumor; LUSC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg26958806 chr6:27640298 NA 0.66 5.78 0.3 1.7e-8 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; LUSC cis rs1568889 0.877 rs34351528 chr11:28304293 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 8.97 0.44 2.13e-17 Bipolar disorder; LUSC cis rs13401104 0.796 rs61160252 chr2:237119074 A/G cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg09184832 chr6:79620586 NA -0.43 -6.85 -0.35 3.64e-11 Intelligence (multi-trait analysis); LUSC cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.07 0.48 5.08e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.25 0.41 3.77e-15 Height; LUSC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg00033643 chr7:134001901 SLC35B4 0.46 7.13 0.36 6.39e-12 Mean platelet volume; LUSC cis rs7568458 0.684 rs3731828 chr2:85806266 C/T cg23752985 chr2:85803571 VAMP8 0.33 6.37 0.33 6.36e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10761482 0.601 rs10733764 chr10:62210345 C/G cg18175470 chr10:62150864 ANK3 -0.53 -7.37 -0.37 1.32e-12 Schizophrenia; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg14878842 chr13:113730426 MCF2L -0.43 -6.89 -0.35 2.81e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2948294 0.524 rs13270062 chr8:8112650 C/A cg08975724 chr8:8085496 FLJ10661 0.55 7.19 0.37 4.2e-12 Red cell distribution width; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23586394 chr17:8286572 RPL26 -0.48 -6.36 -0.33 6.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs7189233 0.531 rs7202621 chr16:53486037 G/A cg09728985 chr16:53543985 NA -0.33 -6.21 -0.32 1.54e-9 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg10896456 chr17:42255109 ASB16;C17orf65 0.48 8.59 0.43 3.41e-16 Total body bone mineral density; LUSC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg26752003 chr8:145688521 CYHR1 0.69 12.03 0.55 6.24e-28 Age at first birth; LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg23034840 chr1:205782522 SLC41A1 0.57 7.86 0.4 5.23e-14 Menarche (age at onset); LUSC cis rs9660992 0.512 rs12123773 chr1:205122420 C/G cg03948781 chr1:205179583 DSTYK 0.32 6.21 0.32 1.53e-9 Mean corpuscular volume;Mean platelet volume; LUSC cis rs734999 0.588 rs2764842 chr1:2529192 A/G cg18854424 chr1:2615690 NA -0.49 -9.66 -0.47 1.21e-19 Ulcerative colitis; LUSC cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.54e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs921665 0.680 rs4854132 chr2:3199378 T/A cg02624386 chr2:3182749 NA 0.61 6.63 0.34 1.37e-10 World class endurance athleticism; LUSC cis rs7582180 0.614 rs3748930 chr2:101010082 G/C cg12002119 chr2:101014098 CHST10 0.38 6.38 0.33 6.04e-10 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.49 -0.33 3.16e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg07700843 chr1:2391317 NA -0.45 -7.28 -0.37 2.43e-12 Non-obstructive azoospermia; LUSC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12667521 chr19:29218732 NA 0.62 8.6 0.43 3.11e-16 Methadone dose in opioid dependence; LUSC cis rs10979 0.928 rs6924967 chr6:143906235 C/T cg25407410 chr6:143891975 LOC285740 -0.68 -10.43 -0.5 3.07e-22 Hypospadias; LUSC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg08499158 chr17:42289980 UBTF -0.51 -8.72 -0.43 1.37e-16 Total body bone mineral density; LUSC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg11764359 chr7:65958608 NA 0.69 11.18 0.52 7.39e-25 Aortic root size; LUSC cis rs10465746 0.967 rs6703382 chr1:84435700 G/A cg10977910 chr1:84465055 TTLL7 0.42 6.23 0.32 1.41e-9 Obesity-related traits; LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg25767906 chr1:53392781 SCP2 0.52 9.52 0.46 3.62e-19 Monocyte count; LUSC cis rs9325144 0.560 rs11183189 chr12:38683770 T/A cg10518543 chr12:38710700 ALG10B 0.42 5.84 0.3 1.22e-8 Morning vs. evening chronotype; LUSC cis rs7523273 0.526 rs2745980 chr1:208018367 A/C cg22525895 chr1:207977042 MIR29B2 0.41 6.91 0.35 2.46e-11 Schizophrenia; LUSC cis rs9916302 0.706 rs9899069 chr17:37540772 A/G cg07936489 chr17:37558343 FBXL20 0.8 9.91 0.48 1.86e-20 Glomerular filtration rate (creatinine); LUSC cis rs7216064 1.000 rs62084249 chr17:65874998 A/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg18876405 chr7:65276391 NA -0.58 -9.39 -0.46 9.82e-19 Aortic root size; LUSC cis rs6690583 0.623 rs11588160 chr1:85444226 T/G cg22153463 chr1:85462885 MCOLN2 0.63 6.01 0.31 4.83e-9 Serum sulfate level; LUSC cis rs826838 0.620 rs11614695 chr12:39331847 C/T cg13010199 chr12:38710504 ALG10B 0.59 9.32 0.45 1.57e-18 Heart rate; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13603510 chr19:3626908 C19orf29 -0.46 -6.16 -0.32 2.05e-9 Bipolar disorder and schizophrenia; LUSC cis rs28595532 0.702 rs72670252 chr4:119337546 A/C cg02775129 chr4:119771670 NA -0.76 -6.33 -0.33 7.79e-10 Cannabis dependence symptom count; LUSC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 9.07 0.44 1.03e-17 Tonsillectomy; LUSC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs2580764 0.516 rs2860453 chr2:55270485 T/G cg09592903 chr2:55203963 RTN4 0.5 10.14 0.49 3.06e-21 Mean platelet volume; LUSC cis rs8078723 0.738 rs3816472 chr17:38142677 A/C cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.49 0.38 6.2800000000000005e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7246967 0.673 rs34726149 chr19:22952111 A/G cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg24397884 chr7:158709396 WDR60 -0.77 -12.3 -0.56 6.04e-29 Height; LUSC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg13206674 chr6:150067644 NUP43 0.6 9.35 0.46 1.26e-18 Lung cancer; LUSC cis rs17253792 0.731 rs28587929 chr14:56097492 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.92 0.7 8.72e-51 Chronic sinus infection; LUSC cis rs7940866 0.903 rs11222411 chr11:130838682 A/G cg12179176 chr11:130786555 SNX19 0.57 8.9 0.44 3.55e-17 Schizophrenia; LUSC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg15494558 chr6:150152522 LRP11 0.33 5.81 0.3 1.46e-8 Lung cancer; LUSC trans rs61931739 0.890 rs11053018 chr12:34105962 T/G cg26384229 chr12:38710491 ALG10B -0.57 -9.06 -0.44 1.1e-17 Morning vs. evening chronotype; LUSC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg01097406 chr16:89675127 NA -0.37 -7.24 -0.37 3.05e-12 Vitiligo; LUSC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg06850241 chr22:41845214 NA 0.32 5.9 0.31 9.16e-9 Vitiligo; LUSC cis rs2980439 0.557 rs2921056 chr8:8319182 T/C cg11608241 chr8:8085544 FLJ10661 0.42 6.26 0.32 1.2e-9 Neuroticism; LUSC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg16049864 chr8:95962084 TP53INP1 -0.47 -7.53 -0.38 4.67e-13 Type 2 diabetes; LUSC cis rs7809950 1.000 rs2520271 chr7:107194949 C/T cg23024343 chr7:107201750 COG5 -0.57 -8.95 -0.44 2.6e-17 Coronary artery disease; LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg06387496 chr7:2775674 GNA12 -0.35 -5.67 -0.3 3.15e-8 Height; LUSC cis rs3806843 1.000 rs4151680 chr5:140186657 A/G cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs3892630 0.878 rs11878394 chr19:33205844 G/C cg22980127 chr19:33182716 NUDT19 0.89 12.1 0.55 3.47e-28 Red blood cell traits; LUSC cis rs2742417 0.624 rs2673030 chr3:45757900 T/G cg10512202 chr3:45649293 LIMD1 0.36 6.14 0.32 2.33e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg18904891 chr8:8559673 CLDN23 -0.57 -8.03 -0.4 1.73e-14 Obesity-related traits; LUSC cis rs208520 0.909 rs62414639 chr6:67023706 G/A cg07460842 chr6:66804631 NA 0.88 8.88 0.44 4.07e-17 Exhaled nitric oxide output; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.68 10.24 0.49 1.4e-21 Lymphocyte counts; LUSC cis rs11105298 0.891 rs4842664 chr12:89938030 G/A cg00757033 chr12:89920650 WDR51B 0.6 10.42 0.5 3.48e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg11764359 chr7:65958608 NA 0.54 7.11 0.36 7.12e-12 Aortic root size; LUSC cis rs7212590 0.655 rs8067568 chr17:57999215 A/G cg10252138 chr17:58120427 NA -0.74 -6.97 -0.36 1.67e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg08859206 chr1:53392774 SCP2 -0.6 -11.3 -0.53 2.77e-25 Monocyte count; LUSC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg17376030 chr22:41985996 PMM1 -0.53 -6.8 -0.35 4.82e-11 Crohn's disease;Inflammatory bowel disease; LUSC trans rs1459104 0.850 rs12802447 chr11:55039889 C/T cg15704280 chr7:45808275 SEPT13 0.76 6.26 0.32 1.21e-9 Body mass index; LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg13395646 chr4:1353034 KIAA1530 0.54 7.98 0.4 2.41e-14 Longevity; LUSC cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg05985134 chr18:33552581 C18orf21 -0.51 -6.9 -0.35 2.64e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.74 11.98 0.55 9.25e-28 Hip circumference adjusted for BMI; LUSC cis rs9359856 0.662 rs1179904 chr6:90322573 A/G cg13799429 chr6:90582589 CASP8AP2 0.74 9.12 0.45 6.97e-18 Bipolar disorder; LUSC cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg08213375 chr14:104286397 PPP1R13B 0.52 10.24 0.49 1.38e-21 Schizophrenia; LUSC cis rs72781680 0.566 rs55987381 chr2:23900938 T/C cg20701182 chr2:24300061 SF3B14 0.59 6.73 0.35 7.42e-11 Lymphocyte counts; LUSC cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg03146154 chr1:46216737 IPP 0.51 7.44 0.38 8.71e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.11 -0.58 5.87e-32 Platelet count; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg22166914 chr1:53195759 ZYG11B 0.57 9.41 0.46 8.01e-19 Monocyte count; LUSC cis rs250677 0.958 rs10056942 chr5:148416114 C/A cg23229984 chr5:148520753 ABLIM3 0.38 6.13 0.32 2.54e-9 Breast cancer; LUSC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg13114125 chr14:105738426 BRF1 0.92 16.22 0.66 5.02e-44 Mean platelet volume;Platelet distribution width; LUSC cis rs4704187 0.640 rs4704188 chr5:74482675 A/T cg03227963 chr5:74354835 NA 0.3 6.54 0.34 2.32e-10 Response to amphetamines; LUSC cis rs10751667 0.600 rs10902264 chr11:1003523 G/A ch.11.42038R chr11:967971 AP2A2 0.47 6.99 0.36 1.46e-11 Alzheimer's disease (late onset); LUSC cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg05343316 chr1:45956843 TESK2 0.72 9.62 0.47 1.65e-19 Platelet count; LUSC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11644478 chr21:40555479 PSMG1 0.96 19.27 0.73 3.73e-56 Cognitive function; LUSC cis rs4295623 0.531 rs2898295 chr8:11595969 C/T cg21775007 chr8:11205619 TDH -0.48 -6.86 -0.35 3.42e-11 Morning vs. evening chronotype; LUSC trans rs4942242 0.663 rs34978818 chr13:44214096 T/C cg19169023 chr15:41853346 TYRO3 -0.6 -9.09 -0.45 8.95e-18 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10789491 1.000 rs1258061 chr1:47105000 G/A cg15501359 chr1:47185051 KIAA0494 -0.83 -11.71 -0.54 9.42e-27 Response to hepatitis C treatment; LUSC cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg14893161 chr1:205819251 PM20D1 0.45 6.32 0.33 8.41e-10 Parkinson's disease; LUSC cis rs6138458 1.000 rs6114984 chr20:24976610 A/G cg06937882 chr20:24974362 C20orf3 -0.44 -7.67 -0.39 1.89e-13 Blood protein levels; LUSC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg09904177 chr6:26538194 HMGN4 0.67 12.18 0.55 1.7e-28 Intelligence (multi-trait analysis); LUSC cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg00012203 chr2:219082015 ARPC2 0.7 11.64 0.54 1.68e-26 Colorectal cancer; LUSC cis rs6754311 0.773 rs309180 chr2:136614255 A/G cg25344623 chr2:136566232 LCT -0.37 -5.66 -0.3 3.31e-8 Mosquito bite size; LUSC cis rs2073300 0.793 rs6048814 chr20:23448411 A/C cg09953122 chr20:23471693 CST8 -0.72 -6.61 -0.34 1.54e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg01416388 chr22:39784598 NA -0.44 -7.34 -0.37 1.65e-12 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.02e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.954 rs13107475 chr4:120393011 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.18 0.32 1.88e-9 Corneal astigmatism; LUSC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg06634786 chr22:41940651 POLR3H 0.54 6.27 0.32 1.12e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7107356 1 rs7107356 chr11:47676170 A/G cg20307385 chr11:47447363 PSMC3 0.56 8.68 0.43 1.84e-16 Neuroticism;Neuroticism (multi-trait analysis); LUSC cis rs10979 1.000 rs9386036 chr6:143890709 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs2404602 0.684 rs1011083 chr15:77007527 C/T cg23625390 chr15:77176239 SCAPER -0.66 -10.09 -0.48 4.38e-21 Blood metabolite levels; LUSC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg02782426 chr3:40428986 ENTPD3 0.35 6.49 0.33 3.06e-10 Renal cell carcinoma; LUSC cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg16850897 chr7:100343110 ZAN 0.37 5.89 0.31 9.47e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg16049864 chr8:95962084 TP53INP1 -0.43 -7.18 -0.37 4.47e-12 Type 2 diabetes; LUSC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg08439880 chr3:133502540 NA -0.35 -6.25 -0.32 1.24e-9 Iron status biomarkers; LUSC cis rs7246657 0.943 rs4969487 chr19:37831039 C/T cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC cis rs11105298 0.891 rs10858903 chr12:89927972 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.4 -0.38 1.12e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2239547 0.563 rs6445547 chr3:52908577 T/C cg18404041 chr3:52824283 ITIH1 -0.57 -9.26 -0.45 2.58e-18 Schizophrenia; LUSC cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg06784218 chr1:46089804 CCDC17 -0.48 -9.21 -0.45 3.67e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10203711 1.000 rs907112 chr2:239566603 C/G cg14580085 chr2:239553406 NA 0.42 7.11 0.36 7.06e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg09365446 chr1:150670422 GOLPH3L 0.46 6.87 0.35 3.12e-11 Melanoma; LUSC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg18681998 chr4:17616180 MED28 0.77 13.81 0.6 1.24e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs853679 0.546 rs200995 chr6:27813694 C/T cg01620082 chr3:125678407 NA 0.75 7.63 0.39 2.48e-13 Depression; LUSC cis rs6700896 0.931 rs11208711 chr1:66147846 G/T cg04111102 chr1:66153794 NA 0.33 7.38 0.37 1.24e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs240764 0.621 rs6925316 chr6:101209137 C/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.32e-9 Neuroticism; LUSC cis rs6700896 0.931 rs4655764 chr1:66126159 C/T cg04111102 chr1:66153794 NA 0.31 6.58 0.34 1.86e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg22601191 chr20:60968625 CABLES2 0.36 5.91 0.31 8.33e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7098414 0.511 rs7916349 chr10:82152638 G/A cg01528321 chr10:82214614 TSPAN14 0.61 9.07 0.44 1.06e-17 Post bronchodilator FEV1; LUSC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg20790798 chr5:1857306 NA -0.47 -8.14 -0.41 8.18e-15 Cardiovascular disease risk factors; LUSC cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.7 0.39 1.61e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6964587 1.000 rs7811873 chr7:91751120 G/A cg01689657 chr7:91764605 CYP51A1 0.34 6.19 0.32 1.79e-9 Breast cancer; LUSC trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg15704280 chr7:45808275 SEPT13 0.67 7.27 0.37 2.5e-12 D-dimer levels; LUSC cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.37 -5.67 -0.3 3.04e-8 Ulcerative colitis; LUSC trans rs1005277 0.579 rs1740735 chr10:38497777 A/C cg17830980 chr10:43048298 ZNF37B -0.55 -9.01 -0.44 1.67e-17 Extrinsic epigenetic age acceleration; LUSC cis rs1712517 0.566 rs7917388 chr10:105054963 C/T cg04362960 chr10:104952993 NT5C2 -0.5 -6.75 -0.35 6.74e-11 Migraine; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20263490 chr11:3013628 NAP1L4 -0.4 -6.1 -0.32 2.86e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs559928 0.556 rs11607903 chr11:63932140 G/A cg05555928 chr11:63887634 MACROD1 -0.49 -6.05 -0.31 3.95e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2303282 0.716 rs2550309 chr16:56434742 G/A cg00500540 chr16:56394104 NA -0.42 -7.14 -0.36 5.98e-12 Breast cancer; LUSC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg11279151 chr3:101281821 RG9MTD1 -0.4 -5.77 -0.3 1.8e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 1.93e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs7615952 0.599 rs6438955 chr3:125730333 C/A cg07211511 chr3:129823064 LOC729375 -0.83 -11.89 -0.55 1.92e-27 Blood pressure (smoking interaction); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg15270950 chr3:30648819 TGFBR2 0.44 6.13 0.32 2.53e-9 Mosquito bite size; LUSC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg25427524 chr10:38739819 LOC399744 -0.74 -14.06 -0.61 1.38e-35 Extrinsic epigenetic age acceleration; LUSC cis rs189798 1.000 rs189798 chr8:8990577 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.24 -0.37 3.18e-12 Myopia (pathological); LUSC cis rs7119 0.717 rs34981488 chr15:77723403 T/G cg27398640 chr15:77910606 LINGO1 -0.28 -5.8 -0.3 1.56e-8 Type 2 diabetes; LUSC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg06238570 chr21:40685208 BRWD1 -0.59 -9.17 -0.45 4.8e-18 Menarche (age at onset); LUSC cis rs2292864 0.764 rs35265764 chr17:45363546 G/T cg18085866 chr17:45331354 ITGB3 -0.73 -6.0 -0.31 5.26e-9 Left atrial antero-posterior diameter; LUSC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.7 -11.76 -0.54 6.15e-27 Total body bone mineral density; LUSC cis rs8077889 0.917 rs72836553 chr17:41909851 A/G cg26893861 chr17:41843967 DUSP3 0.94 14.48 0.62 3.22e-37 Triglycerides; LUSC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg03517284 chr6:25882590 NA 0.39 6.52 0.34 2.6e-10 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.34e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs7824557 0.628 rs7831346 chr8:11193530 C/T cg06636001 chr8:8085503 FLJ10661 0.43 6.31 0.33 8.77e-10 Retinal vascular caliber; LUSC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg12463550 chr7:65579703 CRCP 0.46 6.8 0.35 4.91e-11 Aortic root size; LUSC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg24733560 chr20:60626293 TAF4 0.41 6.76 0.35 6.24e-11 Body mass index; LUSC trans rs1493916 0.905 rs12455290 chr18:31398778 A/G cg27147174 chr7:100797783 AP1S1 -0.65 -10.5 -0.5 1.74e-22 Life satisfaction; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01100864 chr12:122750645 VPS33A 0.76 5.97 0.31 5.95e-9 Cognitive performance; LUSC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg06671706 chr8:8559999 CLDN23 0.5 6.68 0.34 9.98e-11 Obesity-related traits; LUSC cis rs7000551 0.663 rs7827093 chr8:22334610 A/G cg12081754 chr8:22256438 SLC39A14 0.42 6.36 0.33 6.73e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1448094 0.802 rs7397730 chr12:86416212 T/C cg02569458 chr12:86230093 RASSF9 0.38 6.09 0.32 3.09e-9 Major depressive disorder; LUSC cis rs896854 0.517 rs896851 chr8:95950251 T/C cg13393036 chr8:95962371 TP53INP1 -0.35 -6.56 -0.34 2.03e-10 Type 2 diabetes; LUSC cis rs4680 0.737 rs3810595 chr22:19949644 G/C cg06346307 chr22:19949965 COMT -0.35 -7.2 -0.37 3.91e-12 Blood metabolite levels; LUSC cis rs644799 0.710 rs666398 chr11:95551136 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.84 0.6 9.61e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg15704280 chr7:45808275 SEPT13 -0.53 -7.44 -0.38 8.56e-13 Coronary artery disease; LUSC cis rs13082711 0.516 rs1388785 chr3:27371843 T/C cg02860705 chr3:27208620 NA -0.54 -9.56 -0.46 2.62e-19 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs8062405 0.755 rs4787456 chr16:28559573 C/T cg16576597 chr16:28551801 NUPR1 0.34 6.73 0.35 7.35e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9457247 1.000 rs404222 chr6:167402150 G/A cg25258033 chr6:167368657 RNASET2 0.49 8.12 0.41 8.93e-15 Crohn's disease; LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.3e-11 Monocyte count; LUSC cis rs2730245 0.527 rs2036582 chr7:158701708 A/T cg11984989 chr7:158649758 WDR60 0.87 10.19 0.49 2.12e-21 Height; LUSC cis rs7267979 1.000 rs1046073 chr20:25281333 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14690220 chr19:37861935 ZNF527 0.41 6.05 0.31 3.78e-9 Asthma; LUSC cis rs7617773 0.817 rs13072018 chr3:48320332 G/A cg11946769 chr3:48343235 NME6 0.87 13.83 0.6 1.04e-34 Coronary artery disease; LUSC cis rs6714788 0.503 rs11681737 chr2:100679024 T/C cg22139774 chr2:100720529 AFF3 -0.38 -6.01 -0.31 4.83e-9 Intelligence (multi-trait analysis); LUSC cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.53 -0.42 5.32e-16 Body mass index; LUSC cis rs6964587 0.967 rs7781221 chr7:91664645 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.44e-8 Breast cancer; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18402987 chr7:1209562 NA 0.38 5.84 0.3 1.22e-8 Longevity;Endometriosis; LUSC cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.97 -0.31 5.97e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs1358748 0.555 rs2815338 chr1:67535781 C/T cg02640540 chr1:67518911 SLC35D1 0.62 6.52 0.34 2.6e-10 Tuberculosis; LUSC cis rs7119 0.717 rs11639293 chr15:77810845 T/C cg27398640 chr15:77910606 LINGO1 -0.3 -6.49 -0.33 3.14e-10 Type 2 diabetes; LUSC trans rs35110281 0.720 rs162392 chr21:44941406 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.52 0.53 4.31e-26 Mean corpuscular volume; LUSC cis rs34172651 0.917 rs172066 chr16:24756449 C/T cg06028605 chr16:24865363 SLC5A11 0.44 7.66 0.39 1.99e-13 Intelligence (multi-trait analysis); LUSC cis rs1322512 0.959 rs2623954 chr6:152966001 G/A cg27316956 chr6:152958899 SYNE1 -0.34 -5.87 -0.31 1.04e-8 Tonometry; LUSC cis rs9796 0.663 rs11853192 chr15:41368515 G/A cg18705301 chr15:41695430 NDUFAF1 -0.44 -7.6 -0.38 3.03e-13 Menopause (age at onset); LUSC cis rs3007168 1.000 rs3007079 chr14:51613517 A/G cg23942311 chr14:51606299 NA 0.36 5.79 0.3 1.61e-8 Cancer; LUSC cis rs1003719 0.788 rs2156076 chr21:38452634 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.68 11.38 0.53 1.46e-25 Eye color traits; LUSC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22307029 chr19:49891270 CCDC155 0.68 9.57 0.46 2.55e-19 Multiple sclerosis; LUSC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.72 7.31 0.37 1.98e-12 Initial pursuit acceleration; LUSC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg26335602 chr6:28129616 ZNF389 0.45 6.16 0.32 2.09e-9 Depression; LUSC cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg22601191 chr20:60968625 CABLES2 0.6 9.67 0.47 1.15e-19 Colorectal cancer; LUSC cis rs6424115 0.862 rs34845821 chr1:24066486 C/T cg15997130 chr1:24165203 NA -0.46 -6.45 -0.33 3.96e-10 Immature fraction of reticulocytes; LUSC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.49 0.67 4.02e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg08048268 chr3:133502702 NA -0.46 -8.98 -0.44 2.05e-17 Iron status biomarkers; LUSC cis rs6967385 0.934 rs2253353 chr7:12370657 A/G cg20607287 chr7:12443886 VWDE 0.4 5.84 0.3 1.25e-8 Response to taxane treatment (placlitaxel); LUSC cis rs2273669 0.667 rs12215381 chr6:109363217 C/T cg05315195 chr6:109294784 ARMC2 -0.53 -5.84 -0.3 1.22e-8 Prostate cancer; LUSC cis rs74181299 0.964 rs2540949 chr2:65284231 A/T cg05010058 chr2:65284262 CEP68 0.31 6.13 0.32 2.47e-9 Pulse pressure; LUSC cis rs4746818 0.711 rs2491024 chr10:70847084 T/C cg11621586 chr10:70884670 VPS26A 0.99 11.56 0.53 3.14e-26 Left atrial antero-posterior diameter; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11937541 chr2:170441360 PPIG 0.37 6.07 0.32 3.47e-9 Asthma; LUSC cis rs250677 0.958 rs36067 chr5:148417553 T/G cg18129178 chr5:148520854 ABLIM3 -0.66 -10.32 -0.49 7.39e-22 Breast cancer; LUSC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg17554472 chr22:41940697 POLR3H -0.5 -6.06 -0.31 3.67e-9 Vitiligo; LUSC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg16797656 chr11:68205561 LRP5 0.39 7.14 0.36 5.72e-12 Total body bone mineral density; LUSC cis rs3806843 1.000 rs1030165 chr5:140185448 G/A cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC trans rs7939886 0.920 rs11227145 chr11:55839278 C/A cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg26668713 chr11:65405903 SIPA1 0.62 7.53 0.38 4.88e-13 Blood pressure (age interaction); LUSC cis rs11971779 0.680 rs7799598 chr7:139051833 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg05855489 chr10:104503620 C10orf26 0.59 9.51 0.46 3.79e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1729951 0.575 rs16844325 chr3:136678161 C/G cg12473912 chr3:136751656 NA 0.39 6.77 0.35 5.97e-11 Neuroticism; LUSC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg04287289 chr16:89883240 FANCA 0.78 13.7 0.6 3.2e-34 Vitiligo; LUSC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.85 10.76 0.51 2.21e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs981844 0.961 rs6827685 chr4:154662227 C/T cg10279832 chr4:154682576 RNF175 -0.39 -5.81 -0.3 1.44e-8 Response to statins (LDL cholesterol change); LUSC cis rs709400 1.000 rs56660916 chr14:104126137 G/T cg24130564 chr14:104152367 KLC1 -0.51 -7.43 -0.38 9.17e-13 Body mass index; LUSC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg21972741 chr5:435613 AHRR 0.37 6.99 0.36 1.54e-11 Cystic fibrosis severity; LUSC cis rs6840360 0.607 rs6815320 chr4:152432500 T/C cg20465933 chr4:152376761 FAM160A1 0.33 5.94 0.31 7.18e-9 Intelligence (multi-trait analysis); LUSC cis rs1580019 0.961 rs1580022 chr7:32497712 C/A cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.86 0.54 2.63e-27 Cognitive ability; LUSC cis rs12971120 0.504 rs11665154 chr18:72147006 A/C cg25817165 chr18:72167213 CNDP2 -0.59 -8.4 -0.42 1.27e-15 Refractive error; LUSC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg13319975 chr6:146136371 FBXO30 -0.51 -7.81 -0.39 7.54e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.11e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs4363385 0.510 rs6661063 chr1:153036048 C/A cg25856811 chr1:152973957 SPRR3 -0.36 -6.1 -0.32 2.95e-9 Inflammatory skin disease; LUSC cis rs1451375 0.607 rs7807335 chr7:50631862 A/C cg18232548 chr7:50535776 DDC -0.49 -6.61 -0.34 1.55e-10 Malaria; LUSC cis rs1997103 0.906 rs6593232 chr7:55402916 C/T cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6494488 0.500 rs72741325 chr15:64730384 T/C cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Coronary artery disease; LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.39 -6.13 -0.32 2.46e-9 Longevity;Endometriosis; LUSC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.84e-11 Aortic root size; LUSC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -5.89 -0.31 9.52e-9 Developmental language disorder (linguistic errors); LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg23711669 chr6:146136114 FBXO30 0.87 16.13 0.66 1.09e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs561341 0.831 rs11658469 chr17:30206426 T/C cg27661571 chr11:113659931 NA 0.59 6.42 0.33 4.67e-10 Hip circumference adjusted for BMI; LUSC cis rs3736594 0.513 rs2384627 chr2:27774449 G/A cg27432699 chr2:27873401 GPN1 0.67 8.9 0.44 3.75e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg11247378 chr22:39784982 NA -0.64 -12.57 -0.57 6.06e-30 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg20887711 chr4:1340912 KIAA1530 -0.49 -7.37 -0.37 1.34e-12 Obesity-related traits; LUSC cis rs7172118 1 rs7172118 chr15:78862453 C/A cg18825076 chr15:78729989 IREB2 -0.5 -7.81 -0.39 7.26e-14 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg22075328 chr22:23412381 RTDR1;GNAZ 0.48 5.96 0.31 6.45e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 10.16 0.49 2.7e-21 Lymphocyte counts; LUSC cis rs7590368 0.924 rs72779464 chr2:10963159 T/C cg15705551 chr2:10952987 PDIA6 0.57 7.8 0.39 8.2e-14 Educational attainment (years of education); LUSC cis rs7267979 0.834 rs6115100 chr20:25225938 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.27 0.71 3.52e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7011049 1.000 rs72640852 chr8:53838084 G/A cg26025543 chr8:53854495 NA 0.53 6.34 0.33 7.27e-10 Systolic blood pressure; LUSC cis rs9303401 0.659 rs62083525 chr17:56658088 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC cis rs11958404 0.932 rs11949394 chr5:157425198 A/G cg05962755 chr5:157440814 NA 0.5 6.07 0.32 3.45e-9 IgG glycosylation; LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg01879757 chr17:41196368 BRCA1 -0.45 -6.98 -0.36 1.58e-11 Menopause (age at onset); LUSC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.31e-11 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.88 0.31 9.88e-9 Menopause (age at onset); LUSC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg05340658 chr4:99064831 C4orf37 0.66 10.38 0.49 4.53e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs59918340 0.728 rs10112337 chr8:142233573 A/G cg23750338 chr8:142222470 SLC45A4 -0.57 -11.1 -0.52 1.41e-24 Immature fraction of reticulocytes; LUSC cis rs9916302 0.904 rs1619021 chr17:37739274 G/A cg15445000 chr17:37608096 MED1 0.4 6.56 0.34 2e-10 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg11764359 chr7:65958608 NA -0.67 -10.29 -0.49 9.06e-22 Aortic root size; LUSC cis rs1595825 0.891 rs2164070 chr2:198881730 G/C cg00982548 chr2:198649783 BOLL -0.56 -7.06 -0.36 9.65e-12 Ulcerative colitis; LUSC cis rs8013055 0.846 rs10139300 chr14:105974501 A/G cg19700328 chr14:106028568 NA -0.41 -6.94 -0.36 1.99e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs6424115 0.708 rs2076343 chr1:24129126 A/G cg15997130 chr1:24165203 NA -0.5 -7.41 -0.38 1.05e-12 Immature fraction of reticulocytes; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.84 -0.57 5.91e-31 Alzheimer's disease; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg14341449 chr11:18034693 SERGEF 0.43 6.13 0.32 2.53e-9 Calcium levels; LUSC cis rs2486288 0.656 rs2413774 chr15:45549423 C/T cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.78 -0.51 1.91e-23 Glomerular filtration rate; LUSC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg24829409 chr8:58192753 C8orf71 -0.52 -5.96 -0.31 6.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs427691 0.536 rs25916 chr5:108992465 A/G cg17395555 chr5:108820864 NA 0.44 6.8 0.35 4.83e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9394438 0.593 rs10947679 chr6:37543524 C/G cg00985040 chr6:37553208 NA 0.4 8.96 0.44 2.26e-17 IgG glycosylation; LUSC cis rs9916302 0.706 rs649180 chr17:37464959 A/C cg07936489 chr17:37558343 FBXL20 0.83 10.41 0.5 3.52e-22 Glomerular filtration rate (creatinine); LUSC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.38 6.09 0.32 3.02e-9 Self-reported allergy; LUSC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.5 0.62 2.79e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.36 0.37 1.48e-12 Crohn's disease; LUSC cis rs12310956 0.532 rs1525903 chr12:33964163 T/C cg06521331 chr12:34319734 NA -0.47 -7.51 -0.38 5.28e-13 Morning vs. evening chronotype; LUSC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.44 -6.17 -0.32 1.98e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11690935 0.550 rs11676438 chr2:172826668 G/A cg13550731 chr2:172543902 DYNC1I2 0.49 7.31 0.37 1.97e-12 Schizophrenia; LUSC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg20503657 chr10:835505 NA -0.41 -6.03 -0.31 4.37e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs9715521 0.719 rs11936702 chr4:59849081 G/A cg11281224 chr4:60001000 NA -0.46 -6.46 -0.33 3.79e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg25427524 chr10:38739819 LOC399744 0.45 7.41 0.38 1.07e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6667605 0.527 rs6673993 chr1:2552071 T/C cg18854424 chr1:2615690 NA 0.52 10.73 0.51 2.84e-23 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg23743428 chr13:21893420 NA -0.44 -8.84 -0.44 5.57e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs2273669 0.667 rs12374658 chr6:109345930 T/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs9837602 1.000 rs9841186 chr3:99795651 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.42 6.08 0.32 3.21e-9 Breast cancer; LUSC cis rs17824933 1.000 rs12797044 chr11:60768018 T/A cg16817237 chr11:60793675 NA 0.41 6.58 0.34 1.79e-10 Multiple sclerosis; LUSC cis rs1448094 0.967 rs7313443 chr12:86332940 G/A cg00310523 chr12:86230176 RASSF9 0.4 7.33 0.37 1.8e-12 Major depressive disorder; LUSC trans rs72674100 1.000 rs10016008 chr4:97974457 A/G cg09670535 chr1:18959427 PAX7 -0.56 -5.99 -0.31 5.44e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg18402987 chr7:1209562 NA 0.73 7.92 0.4 3.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg20295408 chr7:1910781 MAD1L1 -0.42 -6.01 -0.31 4.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg00339695 chr16:24857497 SLC5A11 -0.37 -5.99 -0.31 5.51e-9 Intelligence (multi-trait analysis); LUSC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.36 -5.79 -0.3 1.63e-8 Total body bone mineral density; LUSC cis rs11864453 0.578 rs2072141 chr16:72133211 G/A cg01557791 chr16:72042693 DHODH -0.43 -6.38 -0.33 6.06e-10 Fibrinogen levels; LUSC trans rs561341 1.000 rs68140514 chr17:30335781 T/C cg27661571 chr11:113659931 NA -0.63 -7.49 -0.38 6.33e-13 Hip circumference adjusted for BMI; LUSC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg18252515 chr7:66147081 NA -1.19 -12.67 -0.57 2.71e-30 Diabetic kidney disease; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.89 0.4 4.42e-14 Prudent dietary pattern; LUSC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg10487724 chr17:56770010 TEX14;RAD51C -0.73 -10.7 -0.51 3.46e-23 Cognitive test performance; LUSC cis rs11098499 0.779 rs80242894 chr4:120375752 G/A cg09307838 chr4:120376055 NA 0.78 11.28 0.53 3.11e-25 Corneal astigmatism; LUSC cis rs778371 0.723 rs2592104 chr2:233645970 G/A cg08000102 chr2:233561755 GIGYF2 0.79 12.77 0.57 1.1e-30 Schizophrenia; LUSC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg09796270 chr17:17721594 SREBF1 0.39 6.81 0.35 4.55e-11 Total body bone mineral density; LUSC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.46 6.87 0.35 3.18e-11 Alzheimer's disease (late onset); LUSC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.79 0.35 5.15e-11 Lung cancer; LUSC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg17800788 chr1:21766015 NBPF3 0.31 6.05 0.31 3.98e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.65 -0.39 2.16e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.57e-10 Lung cancer; LUSC cis rs6580649 0.941 rs58046797 chr12:48487619 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs10465746 0.725 rs12070578 chr1:84349607 A/G cg10977910 chr1:84465055 TTLL7 0.53 7.56 0.38 3.98e-13 Obesity-related traits; LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg08219700 chr8:58056026 NA 0.68 7.92 0.4 3.63e-14 Developmental language disorder (linguistic errors); LUSC cis rs727505 0.954 rs2054586 chr7:124708414 C/T cg23710748 chr7:124431027 NA -0.41 -7.15 -0.36 5.55e-12 Lewy body disease; LUSC cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg26647111 chr11:31128758 NA 0.43 6.16 0.32 2.13e-9 Red blood cell count; LUSC cis rs722599 0.651 rs7159354 chr14:75253847 A/G cg08847533 chr14:75593920 NEK9 0.42 5.85 0.3 1.17e-8 IgG glycosylation; LUSC cis rs225245 0.782 rs161183 chr17:33919475 G/C cg05299278 chr17:33885742 SLFN14 0.31 6.9 0.35 2.68e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs2233152 0.519 rs11083567 chr19:41318306 C/T cg21869046 chr19:41225005 ITPKC 0.39 5.84 0.3 1.23e-8 Kawasaki disease; LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg16325326 chr1:53192061 ZYG11B 0.69 11.17 0.52 7.89e-25 Monocyte count; LUSC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg05855489 chr10:104503620 C10orf26 0.59 9.6 0.46 2.02e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1030877 0.557 rs2278501 chr2:105979506 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.52 -8.77 -0.43 9.41e-17 Obesity-related traits; LUSC trans rs72674100 0.867 rs7656650 chr4:97964570 A/G cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg22467129 chr15:76604101 ETFA -0.43 -6.85 -0.35 3.54e-11 Blood metabolite levels; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg22903657 chr4:1355424 KIAA1530 0.36 6.07 0.32 3.45e-9 Obesity-related traits; LUSC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg01503450 chr10:980765 NA -0.4 -5.73 -0.3 2.2e-8 Eosinophil percentage of granulocytes; LUSC trans rs9944715 0.954 rs6507676 chr18:43739730 T/C cg01718231 chr17:29326311 RNF135 0.46 6.45 0.33 3.84e-10 Red cell distribution width;Mean corpuscular volume; LUSC cis rs2637266 1.000 rs10219107 chr10:78364369 T/C cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs2282300 0.589 rs1717776 chr11:30415776 A/G cg25418670 chr11:30344373 C11orf46 -0.42 -6.5 -0.34 2.95e-10 Morning vs. evening chronotype; LUSC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg04800585 chr6:26043546 HIST1H2BB 0.4 5.96 0.31 6.32e-9 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg13609457 chr4:120235615 NA 0.41 5.64 0.3 3.55e-8 Corneal astigmatism; LUSC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg04455712 chr21:45112962 RRP1B 0.43 8.05 0.4 1.47e-14 Mean corpuscular volume; LUSC cis rs2797160 1.000 rs4897153 chr6:126003403 A/G cg05901451 chr6:126070800 HEY2 -0.57 -8.56 -0.42 4.29e-16 Endometrial cancer; LUSC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg12564285 chr5:131593104 PDLIM4 -0.31 -5.82 -0.3 1.37e-8 Blood metabolite levels; LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg11062466 chr8:58055876 NA 0.73 8.62 0.43 2.79e-16 Developmental language disorder (linguistic errors); LUSC cis rs611744 0.631 rs627392 chr8:109254677 C/T cg21045802 chr8:109455806 TTC35 0.43 6.6 0.34 1.58e-10 Dupuytren's disease; LUSC cis rs17270561 0.636 rs6456697 chr6:25741434 A/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs8099014 0.911 rs4245269 chr18:56110730 G/A cg12907477 chr18:56117327 MIR122 0.44 7.02 0.36 1.28e-11 Platelet count; LUSC cis rs79149102 0.579 rs12594117 chr15:75323648 C/G cg09165964 chr15:75287851 SCAMP5 -0.93 -8.66 -0.43 2.11e-16 Lung cancer; LUSC cis rs3741151 0.773 rs17310361 chr11:73233724 T/C cg17517138 chr11:73019481 ARHGEF17 0.91 7.7 0.39 1.53e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs34779708 0.966 rs10827487 chr10:35406878 T/A cg04310649 chr10:35416472 CREM -0.44 -6.84 -0.35 3.85e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17001868 0.568 rs3788579 chr22:40742989 T/C cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC trans rs7637701 0.773 rs4098 chr3:156501063 T/C cg11006288 chr14:69012387 RAD51L1 0.38 5.96 0.31 6.37e-9 Breast cancer; LUSC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg26441486 chr22:50317300 CRELD2 -0.54 -8.2 -0.41 5.07e-15 Schizophrenia; LUSC cis rs9815354 0.953 rs11717170 chr3:42002811 G/C cg03022575 chr3:42003672 ULK4 -0.51 -5.79 -0.3 1.61e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs4660306 1.000 rs7534467 chr1:45988691 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.53 -0.34 2.48e-10 Homocysteine levels; LUSC cis rs477692 1.000 rs479478 chr10:131428959 G/A cg26102564 chr10:131424627 MGMT 0.41 6.4 0.33 5.33e-10 Response to temozolomide; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg24859228 chr10:12391835 CAMK1D 0.42 6.16 0.32 2.12e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg01879757 chr17:41196368 BRCA1 -0.46 -7.0 -0.36 1.44e-11 Menopause (age at onset); LUSC cis rs10791323 0.569 rs11223609 chr11:133741766 C/T cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC trans rs7824557 0.614 rs2736286 chr8:11227104 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -6.46 -0.33 3.73e-10 Retinal vascular caliber; LUSC cis rs2535633 0.631 rs11915851 chr3:53096047 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -6.88 -0.35 2.94e-11 Body mass index; LUSC cis rs2282802 0.685 rs7717563 chr5:139689968 A/G cg26211634 chr5:139558579 C5orf32 -0.41 -7.83 -0.39 6.34e-14 Intelligence (multi-trait analysis); LUSC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg19717773 chr7:2847554 GNA12 -0.33 -5.73 -0.3 2.26e-8 Height; LUSC cis rs447735 0.587 rs258335 chr16:89720944 G/A cg01097406 chr16:89675127 NA 0.35 6.94 0.35 2.09e-11 Hemoglobin concentration; LUSC cis rs2463822 1.000 rs2513749 chr11:62105391 C/T cg06239285 chr11:62104954 ASRGL1 0.97 10.86 0.51 1.02e-23 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2933343 0.700 rs789238 chr3:128636715 A/G cg11901034 chr3:128598214 ACAD9 -0.42 -6.67 -0.34 1.09e-10 IgG glycosylation; LUSC trans rs9329221 0.935 rs6601450 chr8:10243101 G/T cg15556689 chr8:8085844 FLJ10661 0.53 7.88 0.4 4.66e-14 Neuroticism; LUSC cis rs9462027 0.628 rs2814967 chr6:34712838 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.87 -0.31 1.02e-8 Systemic lupus erythematosus; LUSC cis rs1559088 1.000 rs1559088 chr19:33551061 C/T cg03563238 chr19:33554763 RHPN2 -0.4 -6.36 -0.33 6.72e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.18 -0.49 2.2e-21 Obesity-related traits; LUSC cis rs7582180 0.764 rs12615466 chr2:100924065 C/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); LUSC cis rs1335645 0.570 rs6703407 chr1:111622807 G/A cg00321911 chr1:111669324 DRAM2 -0.65 -6.55 -0.34 2.14e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs754466 0.580 rs10762765 chr10:79566407 T/C cg17075019 chr10:79541650 NA -0.69 -10.45 -0.5 2.56e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg08088566 chr11:430123 ANO9 0.66 7.15 0.36 5.56e-12 Body mass index; LUSC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg09165964 chr15:75287851 SCAMP5 -1.06 -16.07 -0.66 1.91e-43 Blood trace element (Zn levels); LUSC cis rs4919694 0.572 rs12243903 chr10:104906992 T/C cg04362960 chr10:104952993 NT5C2 0.9 11.69 0.54 1.06e-26 Arsenic metabolism; LUSC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -9.93 -0.48 1.62e-20 Cognitive function; LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg22535103 chr8:58192502 C8orf71 -0.76 -7.99 -0.4 2.26e-14 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg13722127 chr7:150037890 RARRES2 0.38 5.68 0.3 2.98e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg20887711 chr4:1340912 KIAA1530 0.42 6.42 0.33 4.6e-10 Obesity-related traits; LUSC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg24675056 chr1:15929824 NA 0.48 8.32 0.41 2.33e-15 Systolic blood pressure; LUSC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg23649088 chr2:200775458 C2orf69 0.53 7.25 0.37 2.9e-12 Schizophrenia; LUSC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg13319975 chr6:146136371 FBXO30 -0.53 -7.94 -0.4 3.09e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg05234568 chr11:5960015 NA -0.6 -8.66 -0.43 2.01e-16 DNA methylation (variation); LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg22638593 chr5:131593259 PDLIM4 0.42 6.34 0.33 7.37e-10 Blood metabolite levels; LUSC cis rs2295359 0.892 rs72676058 chr1:67627681 C/A cg17031739 chr1:67600172 NA 0.46 7.07 0.36 9.18e-12 Psoriasis; LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg11062466 chr8:58055876 NA 0.69 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6484504 0.625 rs10835766 chr11:31374329 C/A cg06552810 chr11:31128660 NA 0.39 6.84 0.35 3.69e-11 Red blood cell count; LUSC cis rs1559088 0.948 rs7247748 chr19:33594023 T/C cg03563238 chr19:33554763 RHPN2 -0.41 -6.52 -0.34 2.56e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2075671 0.903 rs62482249 chr7:100262357 C/A cg20848291 chr7:100343083 ZAN -0.65 -8.69 -0.43 1.6e-16 Other erythrocyte phenotypes; LUSC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg11812906 chr14:75593930 NEK9 -0.64 -11.16 -0.52 8.32e-25 Height; LUSC cis rs7107174 1.000 rs4627115 chr11:78007873 T/G cg02023728 chr11:77925099 USP35 0.49 6.87 0.35 3.11e-11 Testicular germ cell tumor; LUSC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg19257562 chr1:2043853 PRKCZ 0.32 6.49 0.33 3.08e-10 Height; LUSC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs66887589 0.870 rs10518336 chr4:120522934 G/A cg24375607 chr4:120327624 NA 0.53 8.13 0.41 8.39e-15 Diastolic blood pressure; LUSC trans rs7824557 0.564 rs2572389 chr8:11236392 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.54 -0.38 4.51e-13 Retinal vascular caliber; LUSC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.59 -0.38 3.28e-13 Personality dimensions; LUSC cis rs1997103 1.000 rs6953509 chr7:55412179 G/A cg17469321 chr7:55412551 NA 0.64 10.19 0.49 2.02e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9527 0.590 rs11191540 chr10:104822809 G/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.62 -0.34 1.42e-10 Arsenic metabolism; LUSC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg06484146 chr7:12443880 VWDE -0.7 -7.07 -0.36 9.26e-12 Coronary artery disease; LUSC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.15 16.21 0.66 5.28e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9929218 0.581 rs7203337 chr16:68774800 C/G cg01251360 chr16:68772225 CDH1 -0.27 -6.33 -0.33 8.07e-10 Colorectal cancer; LUSC cis rs7572644 0.640 rs6547820 chr2:28281545 G/A cg27432699 chr2:27873401 GPN1 -0.54 -7.24 -0.37 3.12e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.59 -0.5 8.72e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11764590 0.715 rs62444907 chr7:2083267 C/T cg25206134 chr2:45395956 NA 0.6 6.39 0.33 5.67e-10 Neuroticism; LUSC cis rs12681287 0.752 rs13256500 chr8:87247063 G/A cg27223183 chr8:87520930 FAM82B -0.46 -5.73 -0.3 2.19e-8 Caudate activity during reward; LUSC cis rs6688613 0.694 rs12562794 chr1:166828957 A/G cg07049167 chr1:166818506 POGK 0.54 7.79 0.39 8.39e-14 Refractive astigmatism; LUSC cis rs9648716 0.515 rs38739 chr7:140710848 A/G cg23214464 chr7:140373596 ADCK2 0.72 6.24 0.32 1.34e-9 Type 2 diabetes; LUSC cis rs7267979 0.844 rs6050477 chr20:25221547 C/T cg08601574 chr20:25228251 PYGB -0.44 -6.66 -0.34 1.13e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09677724 chr16:70488359 FUK -0.44 -6.56 -0.34 2.05e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2839186 0.934 rs4819221 chr21:47695417 G/T cg05896524 chr21:47604654 C21orf56 -0.4 -6.07 -0.31 3.57e-9 Testicular germ cell tumor; LUSC cis rs116095464 1.000 rs3777237 chr5:307641 C/T cg18584368 chr5:314553 AHRR;PDCD6 0.71 5.82 0.3 1.36e-8 Breast cancer; LUSC trans rs459571 0.635 rs379471 chr9:136890649 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -12.48 -0.56 1.34e-29 Platelet distribution width; LUSC cis rs11690935 0.959 rs11897196 chr2:172585595 G/A cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.65 -0.63 6.79e-38 Schizophrenia; LUSC cis rs238295 0.881 rs6116869 chr20:5594432 G/T cg15842884 chr20:5591925 RP5-1022P6.2 0.46 6.53 0.34 2.43e-10 Occipital cortical area (total cortical area interaction); LUSC cis rs61931739 0.500 rs34703942 chr12:34583776 T/C cg06521331 chr12:34319734 NA 0.41 6.75 0.35 6.66e-11 Morning vs. evening chronotype; LUSC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg00579200 chr11:133705235 NA -0.39 -5.66 -0.3 3.35e-8 Childhood ear infection; LUSC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg14895029 chr7:2775587 GNA12 0.42 6.6 0.34 1.61e-10 Height; LUSC cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg14664628 chr15:75095509 CSK -0.81 -12.51 -0.56 1.03e-29 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1775715 0.651 rs2808033 chr10:32194127 A/T cg04359828 chr10:32216031 ARHGAP12 0.41 7.03 0.36 1.2e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.25 -0.37 3e-12 Developmental language disorder (linguistic errors); LUSC cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg12011299 chr4:100065546 ADH4 0.72 11.06 0.52 1.99e-24 Alcohol dependence; LUSC cis rs11112613 0.762 rs73184078 chr12:105950017 A/G cg03607813 chr12:105948248 NA 0.82 12.44 0.56 1.96e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs12681288 0.676 rs4565481 chr8:1001944 C/T cg04851639 chr8:1020857 NA -0.37 -7.6 -0.38 2.99e-13 Schizophrenia; LUSC cis rs4478858 0.647 rs7524117 chr1:31738416 A/G cg00250761 chr1:31883323 NA -0.33 -7.99 -0.4 2.22e-14 Alcohol dependence; LUSC cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.44 7.91 0.4 3.92e-14 Total body bone mineral density; LUSC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg06108461 chr20:60628389 TAF4 -0.75 -12.35 -0.56 4.07e-29 Body mass index; LUSC cis rs7590368 0.715 rs72779451 chr2:10959407 A/C cg15705551 chr2:10952987 PDIA6 0.58 6.24 0.32 1.31e-9 Educational attainment (years of education); LUSC cis rs7824557 0.510 rs4841524 chr8:11243126 C/G cg21775007 chr8:11205619 TDH -0.7 -10.76 -0.51 2.14e-23 Retinal vascular caliber; LUSC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg22907277 chr7:1156413 C7orf50 0.7 10.25 0.49 1.28e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7511006 1.000 rs5771109 chr22:50678571 T/C cg16473166 chr22:50639996 SELO 0.58 8.09 0.4 1.1e-14 Obesity-related traits; LUSC cis rs3925075 1.000 rs4889543 chr16:31340216 C/T cg02846316 chr16:31340340 ITGAM 0.35 6.41 0.33 5.01e-10 IgA nephropathy; LUSC cis rs4704187 0.687 rs7711762 chr5:74461675 C/T cg03227963 chr5:74354835 NA 0.32 6.83 0.35 4.02e-11 Response to amphetamines; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg05368731 chr17:41323189 NBR1 0.9 15.33 0.64 1.52e-40 Menopause (age at onset); LUSC trans rs7615952 0.576 rs1127717 chr3:125826059 T/C cg07211511 chr3:129823064 LOC729375 -0.76 -9.88 -0.48 2.36e-20 Blood pressure (smoking interaction); LUSC cis rs950169 0.580 rs62021208 chr15:85196244 G/A cg12863693 chr15:85201151 NMB 0.4 8.45 0.42 8.81e-16 Schizophrenia; LUSC cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg13010199 chr12:38710504 ALG10B 0.61 9.56 0.46 2.59e-19 Bladder cancer; LUSC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg17971929 chr21:40555470 PSMG1 0.79 13.89 0.61 6.06e-35 Cognitive function; LUSC cis rs1003719 0.788 rs3787782 chr21:38462909 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC trans rs11671005 0.504 rs3794963 chr19:59071051 C/G cg22037779 chr5:139682734 PFDN1 0.53 7.32 0.37 1.89e-12 Mean platelet volume; LUSC cis rs1577917 0.958 rs12202712 chr6:86578541 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.35 -0.42 1.81e-15 Response to antipsychotic treatment; LUSC cis rs1670533 1.000 rs4690212 chr4:1054898 T/C cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs6541297 0.878 rs4846905 chr1:230279582 C/T cg05784532 chr1:230284198 GALNT2 -0.63 -9.01 -0.44 1.59e-17 Coronary artery disease; LUSC cis rs72781680 1.000 rs72781683 chr2:24247423 T/C cg08917208 chr2:24149416 ATAD2B 0.97 10.04 0.48 6.83e-21 Lymphocyte counts; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg23034840 chr1:205782522 SLC41A1 0.59 8.15 0.41 7.31e-15 Menarche (age at onset); LUSC cis rs7712401 0.601 rs30028 chr5:122283269 G/T cg19077854 chr5:122220652 SNX24 0.42 9.4 0.46 8.87e-19 Mean platelet volume; LUSC cis rs2075165 0.901 rs7542798 chr1:156224304 A/G cg20302342 chr1:156215951 PAQR6 0.33 6.42 0.33 4.62e-10 Tonsillectomy; LUSC cis rs7215564 0.818 rs4889776 chr17:78592385 C/T cg09596252 chr17:78655493 RPTOR 0.57 6.09 0.32 3.02e-9 Myopia (pathological); LUSC cis rs3806843 0.576 rs246008 chr5:140338485 C/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2976388 1.000 rs1045531 chr8:143763547 C/A cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg15117754 chr3:10150083 C3orf24 0.44 5.79 0.3 1.59e-8 Alzheimer's disease; LUSC cis rs240993 0.548 rs1040382 chr6:111902079 C/G cg22127309 chr6:111907043 TRAF3IP2 0.34 6.06 0.31 3.58e-9 Inflammatory skin disease;Psoriasis; LUSC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg06453172 chr10:134556979 INPP5A -0.5 -6.31 -0.33 9.06e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.617 rs4842569 chr12:86468609 T/G cg02569458 chr12:86230093 RASSF9 -0.35 -5.65 -0.3 3.38e-8 Major depressive disorder; LUSC cis rs8062405 0.823 rs7202948 chr16:28558289 T/A cg16576597 chr16:28551801 NUPR1 0.29 5.8 0.3 1.55e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs73200209 0.744 rs55837280 chr12:116645483 A/G cg01776926 chr12:116560359 MED13L -0.5 -6.12 -0.32 2.63e-9 Total body bone mineral density; LUSC cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg18252515 chr7:66147081 NA -1.19 -12.84 -0.57 5.85e-31 Diabetic kidney disease; LUSC cis rs72634258 0.945 rs1883679 chr1:8100451 T/G cg26816564 chr1:7831052 VAMP3 0.5 6.1 0.32 3e-9 Inflammatory bowel disease; LUSC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg13206674 chr6:150067644 NUP43 0.61 9.83 0.47 3.4e-20 Lung cancer; LUSC cis rs12291225 0.679 rs4757245 chr11:14297872 A/C cg19336497 chr11:14380999 RRAS2 -0.57 -11.78 -0.54 5.12e-27 Sense of smell; LUSC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg00310523 chr12:86230176 RASSF9 0.49 9.39 0.46 9.64e-19 Major depressive disorder; LUSC cis rs2859741 0.967 rs575939 chr1:37513854 T/C cg09363841 chr1:37513479 NA -0.36 -7.08 -0.36 8.54e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs9811920 0.660 rs7619512 chr3:99729132 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -6.51 -0.34 2.78e-10 Axial length; LUSC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.18 -0.49 2.18e-21 Menarche (age at onset); LUSC cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.97 0.4 2.5e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.07 0.32 3.41e-9 Lung cancer; LUSC cis rs4820539 1.000 rs885965 chr22:23461425 A/G cg14186256 chr22:23484241 RTDR1 0.92 16.48 0.67 4.4e-45 Bone mineral density; LUSC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg03036452 chr22:46663545 TTC38 0.52 5.7 0.3 2.62e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.86 0.4 5.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg27446573 chr6:127587934 RNF146 0.92 15.08 0.64 1.44e-39 Breast cancer; LUSC cis rs1044826 0.642 rs432387 chr3:139231853 T/G cg15131784 chr3:139108705 COPB2 -0.39 -6.33 -0.33 7.67e-10 Obesity-related traits; LUSC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg00339695 chr16:24857497 SLC5A11 0.6 8.81 0.43 6.73e-17 Intelligence (multi-trait analysis); LUSC trans rs7829975 0.774 rs11775523 chr8:8679176 A/G cg27411982 chr8:10470053 RP1L1 0.41 6.27 0.32 1.14e-9 Mood instability; LUSC trans rs4332037 0.539 rs55993248 chr7:2071132 A/G cg10840412 chr1:235813424 GNG4 0.54 7.09 0.36 8.24e-12 Bipolar disorder; LUSC cis rs908922 0.676 rs533917 chr1:152518294 A/G cg20991723 chr1:152506922 NA 0.52 9.77 0.47 5.39e-20 Hair morphology; LUSC cis rs2637266 1.000 rs1873461 chr10:78338966 A/C cg18941641 chr10:78392320 NA -0.36 -6.44 -0.33 4.07e-10 Pulmonary function; LUSC cis rs765787 0.530 rs2554453 chr15:45522107 A/G cg25801113 chr15:45476975 SHF 0.34 7.07 0.36 9.18e-12 Uric acid levels; LUSC trans rs7824557 0.564 rs2736304 chr8:11236964 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.36e-14 Retinal vascular caliber; LUSC cis rs7043114 0.507 rs10761154 chr9:95144086 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.78 -0.35 5.6e-11 Height; LUSC cis rs9653442 0.564 rs4851253 chr2:100762786 T/G cg07810366 chr2:100720526 AFF3 -0.44 -7.31 -0.37 2.01e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2692947 0.616 rs2301707 chr2:96931846 T/C cg23100626 chr2:96804247 ASTL 0.3 7.16 0.36 5.07e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg13939156 chr17:80058883 NA -0.34 -6.76 -0.35 6.08e-11 Life satisfaction; LUSC cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg00310523 chr12:86230176 RASSF9 0.47 8.53 0.42 5.16e-16 Major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08033548 chr16:75529105 CHST6 -0.47 -6.33 -0.33 8.05e-10 Bipolar disorder and schizophrenia; LUSC trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg02574844 chr11:5959923 NA -0.44 -6.31 -0.33 8.96e-10 DNA methylation (variation); LUSC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.897 rs13014906 chr2:15614404 T/C cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg21724239 chr8:58056113 NA 0.55 6.37 0.33 6.1e-10 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg20307385 chr11:47447363 PSMC3 0.43 5.72 0.3 2.36e-8 Subjective well-being; LUSC cis rs16976116 0.901 rs28526269 chr15:55499190 A/G cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg24642439 chr20:33292090 TP53INP2 0.48 7.2 0.37 4e-12 Glomerular filtration rate (creatinine); LUSC cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs2932538 0.883 rs6701351 chr1:113139196 G/A cg22162597 chr1:113214053 CAPZA1 0.53 7.67 0.39 1.96e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg11965913 chr1:205819406 PM20D1 0.93 18.94 0.72 7.53e-55 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17409405 chr7:5085485 RBAK -0.41 -6.18 -0.32 1.87e-9 Electrocardiographic conduction measures; LUSC cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg10978503 chr1:24200527 CNR2 -0.45 -9.37 -0.46 1.11e-18 Immature fraction of reticulocytes; LUSC cis rs526231 0.543 rs152123 chr5:102531919 A/G cg23492399 chr5:102201601 PAM 0.45 5.77 0.3 1.78e-8 Primary biliary cholangitis; LUSC cis rs7615316 1.000 rs2140432 chr3:142343552 A/G cg16271453 chr3:142027066 XRN1 0.35 5.91 0.31 8.55e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9837602 0.872 rs34996634 chr3:99738219 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 5.74 0.3 2.12e-8 Breast cancer; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -7.99 -0.4 2.23e-14 Lymphocyte counts; LUSC cis rs4711350 0.765 rs1318691 chr6:33761884 G/A cg18005901 chr6:33739558 LEMD2 -0.4 -5.88 -0.31 1e-8 Schizophrenia; LUSC cis rs3820068 0.608 rs7519899 chr1:16045579 A/G cg17385448 chr1:15911702 AGMAT 0.37 6.01 0.31 4.9e-9 Systolic blood pressure; LUSC cis rs8044995 0.563 rs3743743 chr16:68397775 C/T cg09835421 chr16:68378352 PRMT7 -0.83 -8.84 -0.44 5.53e-17 Schizophrenia; LUSC cis rs716595 1.000 rs72830457 chr10:112010671 A/C cg13996003 chr10:112034540 MXI1 -0.69 -5.97 -0.31 6.14e-9 Normalized brain volume; LUSC cis rs7937682 0.814 rs1619652 chr11:111469757 G/A cg22437258 chr11:111473054 SIK2 0.5 6.83 0.35 4.11e-11 Primary sclerosing cholangitis; LUSC cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.81 0.35 4.57e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg09177884 chr7:1199841 ZFAND2A -0.42 -5.66 -0.3 3.31e-8 Longevity;Endometriosis; LUSC cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg16850897 chr7:100343110 ZAN 0.37 5.89 0.31 9.47e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg20891283 chr12:69753455 YEATS4 0.66 10.44 0.5 2.94e-22 Blood protein levels; LUSC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg08975724 chr8:8085496 FLJ10661 0.49 7.41 0.38 1.05e-12 Mood instability; LUSC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg05973401 chr12:123451056 ABCB9 0.55 6.81 0.35 4.68e-11 Neutrophil percentage of white cells; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg09177884 chr7:1199841 ZFAND2A -0.47 -6.26 -0.32 1.17e-9 Longevity;Endometriosis; LUSC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg20607287 chr7:12443886 VWDE -0.57 -6.17 -0.32 1.98e-9 Coronary artery disease; LUSC cis rs10934753 0.632 rs1447661 chr3:125924981 A/G cg01346077 chr3:125931526 NA 0.48 8.99 0.44 1.88e-17 Plasma homocysteine levels (post-methionine load test); LUSC cis rs11105298 0.891 rs10858890 chr12:89907166 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -7.52 -0.38 4.95e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1577917 1.000 rs6936048 chr6:86702608 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.94 -0.36 2.02e-11 Response to antipsychotic treatment; LUSC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.51 6.51 0.34 2.71e-10 Menarche (age at onset); LUSC cis rs4901869 0.864 rs12891575 chr14:59334342 T/A cg02291164 chr14:59296302 NA 0.58 10.93 0.51 5.63e-24 Panic disorder; LUSC cis rs9788721 0.900 rs4243084 chr15:78911672 G/C cg18825076 chr15:78729989 IREB2 -0.49 -7.71 -0.39 1.48e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg21862992 chr11:68658383 NA 0.51 8.11 0.41 9.65e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg23758822 chr17:41437982 NA 1.03 19.58 0.73 2.08e-57 Menopause (age at onset); LUSC cis rs7592578 0.882 rs7569128 chr2:191446691 C/A cg10560079 chr2:191398806 TMEM194B 0.7 8.82 0.43 6.58e-17 Diastolic blood pressure; LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs11971779 0.680 rs10085901 chr7:139108989 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7246657 0.943 rs13345116 chr19:37847098 A/T cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg27165867 chr14:105738592 BRF1 -0.51 -7.5 -0.38 5.75e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs8032315 0.965 rs4932373 chr15:91429287 A/C cg04510874 chr15:91427884 FES 0.33 6.49 0.33 3.03e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05929132 chr15:66586024 DIS3L -0.51 -6.17 -0.32 2.02e-9 Bipolar disorder and schizophrenia; LUSC cis rs3096299 0.900 rs4785663 chr16:89434888 G/A cg02187348 chr16:89574699 SPG7 0.47 7.05 0.36 1.04e-11 Multiple myeloma (IgH translocation); LUSC cis rs17685 0.753 rs6953665 chr7:75769049 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg23172400 chr8:95962367 TP53INP1 0.36 6.76 0.35 6.31e-11 Type 2 diabetes; LUSC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg12564285 chr5:131593104 PDLIM4 0.33 6.04 0.31 4.16e-9 Blood metabolite levels; LUSC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg22535103 chr8:58192502 C8orf71 -0.69 -7.28 -0.37 2.35e-12 Developmental language disorder (linguistic errors); LUSC cis rs4595586 0.545 rs12812262 chr12:39392567 T/A cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs243505 0.762 rs2007404 chr7:148487395 A/G cg09806900 chr7:148480153 CUL1 0.55 8.15 0.41 7.35e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8017423 0.967 rs11621364 chr14:90709115 A/G cg04374321 chr14:90722782 PSMC1 0.75 12.09 0.55 3.85e-28 Mortality in heart failure; LUSC cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg05347473 chr6:146136440 FBXO30 -0.59 -10.57 -0.5 1.02e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311676 0.632 rs11719192 chr3:58431817 C/G cg26110898 chr3:58419937 PDHB 0.41 6.69 0.34 9.7e-11 Systemic lupus erythematosus; LUSC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.27 -0.49 1.06e-21 Gut microbiome composition (summer); LUSC cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg11657440 chr19:46296263 DMWD -0.68 -10.24 -0.49 1.34e-21 Coronary artery disease; LUSC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg02475777 chr4:1388615 CRIPAK 0.43 6.39 0.33 5.68e-10 Obesity-related traits; LUSC cis rs751728 0.626 rs4711348 chr6:33736295 G/A cg25922239 chr6:33757077 LEMD2 0.43 6.39 0.33 5.73e-10 Crohn's disease; LUSC cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg09184832 chr6:79620586 NA -0.42 -6.8 -0.35 4.71e-11 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg19592336 chr6:28129416 ZNF389 0.5 6.57 0.34 1.94e-10 Parkinson's disease; LUSC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg21699342 chr2:239360505 ASB1 0.56 10.48 0.5 2.04e-22 Multiple system atrophy; LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg05368731 chr17:41323189 NBR1 0.94 15.86 0.66 1.24e-42 Menopause (age at onset); LUSC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs8078723 0.966 rs57065891 chr17:38168227 C/T cg17467752 chr17:38218738 THRA 0.77 12.44 0.56 1.94e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs6502050 0.835 rs8078950 chr17:80122327 T/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.71e-10 Life satisfaction; LUSC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08677398 chr8:58056175 NA 0.5 7.85 0.39 5.58e-14 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg08280861 chr8:58055591 NA 0.59 7.3 0.37 2.12e-12 Developmental language disorder (linguistic errors); LUSC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg26752003 chr8:145688521 CYHR1 -0.41 -6.53 -0.34 2.41e-10 Age at first birth; LUSC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg07741184 chr6:167504864 NA 0.38 6.8 0.35 4.7e-11 Crohn's disease; LUSC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11890956 chr21:40555474 PSMG1 1.02 20.48 0.75 5.84e-61 Cognitive function; LUSC cis rs7428 0.545 rs2366404 chr2:85551779 G/A cg24342717 chr2:85555507 TGOLN2 -0.74 -11.94 -0.55 1.29e-27 Ear protrusion; LUSC cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg12935359 chr14:103987150 CKB -0.65 -10.61 -0.5 7.5e-23 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08512882 chr17:42402347 SLC25A39 -0.48 -7.07 -0.36 8.91e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg12963246 chr6:28129442 ZNF389 0.52 7.09 0.36 7.99e-12 Depression; LUSC cis rs3774830 0.748 rs17367445 chr4:5464903 C/T cg26943120 chr4:5472116 STK32B 0.29 5.77 0.3 1.84e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs9457247 0.967 rs86755 chr6:167403108 T/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg10253484 chr15:75165896 SCAMP2 -0.49 -7.46 -0.38 7.54e-13 Breast cancer; LUSC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC trans rs4332037 0.539 rs11764780 chr7:2020904 G/C cg10840412 chr1:235813424 GNG4 0.6 7.73 0.39 1.26e-13 Bipolar disorder; LUSC cis rs79349575 0.749 rs46521 chr17:46988529 A/G cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.82e-13 Type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14551182 chr11:16626476 NA -0.44 -5.99 -0.31 5.3e-9 Bipolar disorder and schizophrenia; LUSC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg22029157 chr1:209979665 IRF6 0.74 8.74 0.43 1.14e-16 Coronary artery disease; LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg26314531 chr2:26401878 FAM59B -0.7 -9.67 -0.47 1.16e-19 Gut microbiome composition (summer); LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg24675658 chr1:53192096 ZYG11B 0.58 9.14 0.45 6.02e-18 Monocyte count; LUSC cis rs377070 0.966 rs411043 chr4:123633221 G/C cg10495464 chr4:123653540 BBS12;LOC729338 0.5 7.34 0.37 1.64e-12 Mosquito bite size; LUSC cis rs12541635 0.966 rs114386112 chr8:107036340 G/A cg10147462 chr8:107024639 NA 0.55 9.83 0.47 3.36e-20 Age of smoking initiation; LUSC trans rs11098499 1.000 rs28374891 chr4:120183550 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.23 0.32 1.42e-9 Corneal astigmatism; LUSC cis rs12421382 0.659 rs11600110 chr11:109392438 A/G cg11473876 chr11:109292803 C11orf87 0.41 6.58 0.34 1.82e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7809950 1.000 rs2057837 chr7:107222725 C/G cg23024343 chr7:107201750 COG5 0.52 8.16 0.41 7.01e-15 Coronary artery disease; LUSC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg19748678 chr4:122722346 EXOSC9 0.74 10.58 0.5 9.68e-23 Type 2 diabetes; LUSC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.84 0.47 3.12e-20 Hip circumference adjusted for BMI; LUSC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.6 -5.75 -0.3 2.01e-8 Cerebrospinal P-tau181p levels; LUSC cis rs2235544 0.565 rs620907 chr1:54468166 T/G cg25741118 chr1:54482237 LDLRAD1 0.28 5.98 0.31 5.61e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg05347473 chr6:146136440 FBXO30 0.41 6.89 0.35 2.73e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs11758351 0.866 rs2069018 chr6:26205718 T/C cg01420254 chr6:26195488 NA 0.68 7.52 0.38 5.21e-13 Gout;Renal underexcretion gout; LUSC cis rs6690583 0.623 rs7522239 chr1:85484366 C/T cg11262906 chr1:85462892 MCOLN2 0.67 6.8 0.35 4.78e-11 Serum sulfate level; LUSC cis rs4917300 0.605 rs10108708 chr8:143102886 A/G cg25363559 chr8:143086065 NA -0.32 -7.17 -0.37 4.91e-12 Amyotrophic lateral sclerosis; LUSC cis rs7100689 0.754 rs10736339 chr10:82059970 G/C cg01528321 chr10:82214614 TSPAN14 0.98 14.61 0.62 1.03e-37 Post bronchodilator FEV1; LUSC trans rs1027479 0.813 rs1391198 chr8:109723998 A/T cg14904725 chr13:113777045 F10 -0.25 -6.12 -0.32 2.58e-9 Facial morphology (factor 6, height of vermillion lower lip); LUSC cis rs17095355 1.000 rs11194917 chr10:111692552 C/G cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.91 -0.35 2.48e-11 Biliary atresia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17193163 chr11:66056724 YIF1A 0.41 6.38 0.33 5.93e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs10885122 0.850 rs10509937 chr10:113029061 A/C cg13719885 chr3:127795394 NA -0.52 -6.14 -0.32 2.31e-9 Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function;Fasting blood glucose; LUSC cis rs2544523 0.511 rs2544536 chr2:15906854 T/C cg26669897 chr2:15909070 NA 0.34 7.13 0.36 6.08e-12 Asthma or chronic obstructive pulmonary disease; LUSC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg19717773 chr7:2847554 GNA12 -0.35 -5.68 -0.3 2.96e-8 Height; LUSC cis rs4363385 0.747 rs4319267 chr1:152972699 T/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.83 -0.39 6.43e-14 Inflammatory skin disease; LUSC cis rs68170813 0.559 rs4730232 chr7:106942382 G/C cg02696742 chr7:106810147 HBP1 -0.64 -9.71 -0.47 8.2e-20 Coronary artery disease; LUSC cis rs1018836 0.828 rs7006279 chr8:91605364 A/G cg16814680 chr8:91681699 NA -0.69 -11.26 -0.52 3.92e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg18876405 chr7:65276391 NA 0.76 13.54 0.6 1.31e-33 Calcium levels; LUSC cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.11e-8 Breast cancer; LUSC cis rs4820539 1.000 rs1051875 chr22:23466031 G/A cg14186256 chr22:23484241 RTDR1 0.93 16.97 0.68 4.93e-47 Bone mineral density; LUSC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.12 17.03 0.68 2.85e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg07424592 chr7:64974309 NA 0.7 6.15 0.32 2.24e-9 Diabetic kidney disease; LUSC cis rs6700896 0.500 rs67051863 chr1:66114975 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.36 0.33 6.62e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs57920188 0.568 rs12137595 chr1:4094068 C/T cg20703997 chr1:4087676 NA 0.67 8.08 0.4 1.16e-14 Interleukin-17 levels; LUSC cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg05855489 chr10:104503620 C10orf26 0.59 9.51 0.46 3.79e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7605378 0.567 rs717915 chr2:200714766 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.43 5.96 0.31 6.24e-9 Osteoporosis; LUSC cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg26384229 chr12:38710491 ALG10B 0.87 14.9 0.63 7.8e-39 Bladder cancer; LUSC cis rs2180341 0.521 rs12203812 chr6:127617816 A/T cg27446573 chr6:127587934 RNF146 0.47 7.15 0.36 5.51e-12 Breast cancer; LUSC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.16 -0.32 2.13e-9 Life satisfaction; LUSC cis rs356992 0.957 rs356979 chr2:60747743 T/C cg08426369 chr2:60753602 BCL11A 0.44 6.01 0.31 4.76e-9 Educational attainment (years of education); LUSC cis rs9905704 0.633 rs8068455 chr17:56589381 C/T cg12560992 chr17:57184187 TRIM37 -0.5 -5.88 -0.31 1e-8 Testicular germ cell tumor; LUSC cis rs11155671 0.530 rs6939761 chr6:150210994 T/C cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.67e-10 Testicular germ cell tumor; LUSC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg06453172 chr10:134556979 INPP5A -0.5 -6.35 -0.33 6.9e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg18876405 chr7:65276391 NA 0.68 12.13 0.55 2.6e-28 Aortic root size; LUSC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg24642844 chr7:1081250 C7orf50 -0.48 -7.66 -0.39 2.07e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs208520 0.690 rs6929762 chr6:66709277 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.85 0.68 1.53e-46 Exhaled nitric oxide output; LUSC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg04398451 chr17:18023971 MYO15A -0.48 -7.65 -0.39 2.12e-13 Total body bone mineral density; LUSC cis rs4891159 0.790 rs660029 chr18:74149668 A/G cg24786174 chr18:74118243 ZNF516 0.9 18.48 0.71 4.92e-53 Longevity; LUSC cis rs7520050 0.743 rs61789988 chr1:46085242 G/C cg06784218 chr1:46089804 CCDC17 -0.3 -5.87 -0.31 1.04e-8 Red blood cell count;Reticulocyte count; LUSC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg05294307 chr14:35346193 BAZ1A -0.49 -5.71 -0.3 2.55e-8 Psoriasis; LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg21548813 chr6:291882 DUSP22 -0.48 -7.02 -0.36 1.28e-11 Menopause (age at onset); LUSC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.01 0.4 1.9e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg13319975 chr6:146136371 FBXO30 0.54 8.23 0.41 4.12e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs6665290 0.901 rs61834005 chr1:227202789 C/T cg10327440 chr1:227177885 CDC42BPA -1.2 -35.46 -0.89 2.79e-115 Myeloid white cell count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19844325 chr19:18314808 RAB3A -0.5 -6.14 -0.32 2.31e-9 Bipolar disorder and schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23888375 chr2:203776317 ALS2CR8;WDR12 -0.51 -6.38 -0.33 5.79e-10 Bipolar disorder and schizophrenia; LUSC cis rs1997103 1.000 rs10224446 chr7:55413147 C/G cg17469321 chr7:55412551 NA 0.65 10.53 0.5 1.45e-22 QRS interval (sulfonylurea treatment interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11310125 chr2:113239311 TTL -0.47 -6.09 -0.32 3.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs7712401 0.580 rs185008 chr5:122274734 T/C cg19077854 chr5:122220652 SNX24 0.42 9.32 0.45 1.68e-18 Mean platelet volume; LUSC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.58 0.5 9.76e-23 Schizophrenia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20136444 chr3:183903974 ABCF3 0.36 6.03 0.31 4.33e-9 Asthma; LUSC trans rs6601327 0.602 rs7829463 chr8:9649691 C/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.49 -0.33 3.13e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg05084668 chr3:125655381 ALG1L -0.49 -6.86 -0.35 3.26e-11 Blood pressure (smoking interaction); LUSC cis rs28374715 0.662 rs28587487 chr15:41495460 C/T cg18705301 chr15:41695430 NDUFAF1 -0.86 -15.23 -0.64 3.98e-40 Ulcerative colitis; LUSC cis rs9303401 0.614 rs34920953 chr17:56589406 G/A cg25039879 chr17:56429692 SUPT4H1 0.71 9.48 0.46 4.81e-19 Cognitive test performance; LUSC cis rs7605827 0.930 rs4410258 chr2:15594984 A/C cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.26e-17 Educational attainment (years of education); LUSC cis rs5758511 0.773 rs11913631 chr22:42347371 G/T cg00645731 chr22:42541494 CYP2D7P1 0.42 6.91 0.35 2.4e-11 Birth weight; LUSC cis rs8044868 0.586 rs8182213 chr16:72080005 C/T cg16579770 chr16:72058938 DHODH 0.34 5.79 0.3 1.65e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg14664628 chr15:75095509 CSK -0.58 -9.06 -0.44 1.12e-17 Breast cancer; LUSC cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg13010199 chr12:38710504 ALG10B -0.59 -9.26 -0.45 2.54e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs9790314 1.000 rs336579 chr3:161086610 G/A cg03342759 chr3:160939853 NMD3 -0.47 -7.73 -0.39 1.31e-13 Morning vs. evening chronotype; LUSC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg07701084 chr6:150067640 NUP43 0.54 8.03 0.4 1.71e-14 Lung cancer; LUSC cis rs4631830 0.720 rs2611512 chr10:51515534 A/G cg10326726 chr10:51549505 MSMB -0.34 -5.9 -0.31 9.14e-9 Prostate-specific antigen levels; LUSC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.47 7.74 0.39 1.18e-13 Total body bone mineral density; LUSC cis rs1832871 0.672 rs6899322 chr6:158753669 G/T cg07165851 chr6:158734300 TULP4 0.47 7.17 0.37 4.79e-12 Height; LUSC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg10057126 chr4:77819792 ANKRD56 0.53 7.88 0.4 4.75e-14 Emphysema distribution in smoking; LUSC cis rs240764 0.782 rs7748644 chr6:101166809 T/G cg09795085 chr6:101329169 ASCC3 -0.41 -5.88 -0.31 1e-8 Neuroticism; LUSC cis rs7216064 1.000 rs12602912 chr17:65870073 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -7.69 -0.39 1.62e-13 Glomerular filtration rate (creatinine); LUSC cis rs9389248 0.690 rs2294321 chr6:135253048 T/G cg24558204 chr6:135376177 HBS1L -0.59 -8.67 -0.43 1.9e-16 High light scatter reticulocyte percentage of red cells; LUSC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg17330251 chr7:94953956 PON1 -0.37 -5.87 -0.31 1.06e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2637266 0.749 rs4979830 chr10:78457484 C/T cg18941641 chr10:78392320 NA 0.34 6.12 0.32 2.59e-9 Pulmonary function; LUSC cis rs9473147 0.543 rs4715025 chr6:47483653 C/G cg12968598 chr6:47444699 CD2AP 0.53 8.07 0.4 1.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg05025164 chr4:1340916 KIAA1530 0.53 8.44 0.42 9.9e-16 Longevity; LUSC cis rs2742234 0.590 rs2075912 chr10:43622217 T/C cg15436174 chr10:43711423 RASGEF1A -0.44 -7.34 -0.37 1.67e-12 Hirschsprung disease; LUSC cis rs1448094 0.872 rs7975457 chr12:86410404 C/T cg00310523 chr12:86230176 RASSF9 0.35 6.31 0.33 8.79e-10 Major depressive disorder; LUSC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.19e-20 Aortic root size; LUSC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs877282 0.853 rs7069720 chr10:754487 A/G cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs7000551 0.663 rs7827118 chr8:22334669 T/G cg12081754 chr8:22256438 SLC39A14 0.45 6.75 0.35 6.5e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs983392 0.678 rs4938931 chr11:60026613 G/T cg20284999 chr11:59952153 MS4A6A 0.37 6.3 0.33 9.38e-10 Alzheimer's disease (late onset); LUSC cis rs9534288 0.797 rs9526134 chr13:46618046 G/T cg15192986 chr13:46630673 CPB2 -0.66 -10.57 -0.5 1.01e-22 Blood protein levels; LUSC cis rs7582180 0.629 rs11123826 chr2:100936276 G/T cg08017756 chr2:100939284 LONRF2 0.46 8.56 0.42 4.31e-16 Intelligence (multi-trait analysis); LUSC cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs2153535 1.000 rs2153535 chr6:8369679 C/G cg07606381 chr6:8435919 SLC35B3 -0.5 -7.53 -0.38 4.86e-13 Motion sickness; LUSC cis rs17685 0.753 rs4728550 chr7:75670988 C/A cg16489192 chr7:75678113 MDH2;STYXL1 0.52 8.06 0.4 1.41e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10493773 0.502 rs12061951 chr1:86081453 A/G cg17807903 chr1:86174739 ZNHIT6 -0.36 -7.74 -0.39 1.22e-13 Urate levels in overweight individuals; LUSC cis rs6574644 1.000 rs12588234 chr14:81773032 C/A cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC trans rs877282 0.755 rs2486579 chr10:785647 G/A cg13042288 chr15:90349979 ANPEP -0.41 -6.23 -0.32 1.43e-9 Uric acid levels; LUSC cis rs12928939 0.815 rs1345868 chr16:71669624 G/T cg03805757 chr16:71968109 PKD1L3 -0.39 -5.72 -0.3 2.31e-8 Post bronchodilator FEV1; LUSC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.35 -7.42 -0.38 9.65e-13 Hemoglobin concentration; LUSC cis rs9611519 1.000 rs9611519 chr22:41613188 C/T cg13813247 chr22:41461852 NA -0.36 -6.41 -0.33 4.96e-10 Neuroticism; LUSC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg07389463 chr12:132296394 NA 0.47 8.95 0.44 2.58e-17 Migraine; LUSC cis rs11758351 0.660 rs11753655 chr6:26220109 C/T cg23601095 chr6:26197514 HIST1H3D 0.68 7.42 0.38 9.69e-13 Gout;Renal underexcretion gout; LUSC cis rs7605827 0.930 rs3792579 chr2:15534723 A/G cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs870825 0.655 rs10033035 chr4:185630880 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.12 0.58 5.24e-32 Blood protein levels; LUSC cis rs17255340 0.577 rs34639488 chr6:84107888 G/T cg08257003 chr6:84140564 ME1 0.32 7.2 0.37 4.02e-12 Platelet-derived growth factor BB levels; LUSC cis rs6556937 0.627 rs10067766 chr5:96002020 A/G cg07690455 chr5:95997198 CAST 0.46 6.39 0.33 5.57e-10 Blood protein levels; LUSC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg18196295 chr10:418757 DIP2C 0.48 8.05 0.4 1.49e-14 Psychosis in Alzheimer's disease; LUSC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg05373962 chr22:49881684 NA -0.43 -10.23 -0.49 1.53e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.48 -0.33 3.21e-10 Bipolar disorder and schizophrenia; LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.94 -12.33 -0.56 4.72e-29 Platelet count; LUSC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg18876405 chr7:65276391 NA -0.74 -13.38 -0.59 5.27e-33 Aortic root size; LUSC cis rs6740322 0.895 rs6760797 chr2:43559612 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.53 -0.38 4.87e-13 Coronary artery disease; LUSC cis rs733592 0.929 rs4760678 chr12:48461581 T/C cg24011408 chr12:48396354 COL2A1 -0.43 -7.22 -0.37 3.61e-12 Plateletcrit; LUSC cis rs10992471 0.603 rs7864575 chr9:95304647 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -6.98 -0.36 1.57e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs9951602 0.512 rs12607561 chr18:76644284 G/A cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg08798685 chr6:27730294 NA -0.59 -5.71 -0.3 2.49e-8 Breast cancer; LUSC cis rs35883536 0.647 rs10875328 chr1:101169328 C/T cg06223162 chr1:101003688 GPR88 -0.44 -7.79 -0.39 8.4e-14 Monocyte count; LUSC cis rs9487051 0.768 rs399561 chr6:109524979 G/A cg00509249 chr6:109615579 CCDC162 -0.33 -5.74 -0.3 2.09e-8 Reticulocyte fraction of red cells; LUSC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4619890 0.528 rs28558196 chr4:7880360 T/A cg24250820 chr4:7887609 AFAP1 0.36 6.13 0.32 2.52e-9 Glaucoma (primary open-angle); LUSC cis rs9640161 0.830 rs35840727 chr7:150063204 A/G cg27494647 chr7:150038898 RARRES2 0.43 6.5 0.33 3e-10 Blood protein levels;Circulating chemerin levels; LUSC trans rs2243480 1.000 rs1638734 chr7:66097539 A/C cg10756647 chr7:56101905 PSPH 0.87 8.85 0.44 5.16e-17 Diabetic kidney disease; LUSC cis rs611744 0.631 rs627392 chr8:109254677 C/T cg18478394 chr8:109455254 TTC35 0.41 6.29 0.33 9.7e-10 Dupuytren's disease; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg03790207 chr6:42947109 PEX6 -0.46 -7.06 -0.36 9.53e-12 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg08313168 chr12:7315531 NA 0.46 6.02 0.31 4.48e-9 Lung disease severity in cystic fibrosis; LUSC cis rs17095355 0.579 rs72828224 chr10:111702047 A/G cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.67 -0.39 1.93e-13 Biliary atresia; LUSC trans rs4714291 0.963 rs1743969 chr6:40096918 A/G cg02267698 chr19:7991119 CTXN1 0.53 7.4 0.38 1.15e-12 Strep throat; LUSC cis rs17253792 0.749 rs74979160 chr14:56097568 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs7582180 0.663 rs6542944 chr2:100988038 T/C cg08017756 chr2:100939284 LONRF2 -0.42 -7.87 -0.4 4.97e-14 Intelligence (multi-trait analysis); LUSC cis rs6714788 0.503 rs1370356 chr2:100675241 G/C cg22139774 chr2:100720529 AFF3 -0.38 -6.01 -0.31 4.83e-9 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.655 rs9444352 chr6:86257535 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 7.24 0.37 3.18e-12 Response to antipsychotic treatment; LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs722599 0.748 rs61978948 chr14:75363369 G/A cg08847533 chr14:75593920 NEK9 -0.47 -6.84 -0.35 3.74e-11 IgG glycosylation; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00656289 chr6:158653327 NA -0.44 -6.71 -0.34 8.31e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 13.62 0.6 6.38e-34 Alzheimer's disease; LUSC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg00310523 chr12:86230176 RASSF9 0.54 10.05 0.48 5.93e-21 Major depressive disorder; LUSC cis rs9300255 0.602 rs1051431 chr12:123645803 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.17 -0.32 1.95e-9 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg17366294 chr4:99064904 C4orf37 0.57 9.91 0.48 1.76e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.46e-10 Total body bone mineral density; LUSC cis rs9311676 0.632 rs7624283 chr3:58369897 G/A cg13750441 chr3:58318267 PXK 0.35 6.7 0.34 8.72e-11 Systemic lupus erythematosus; LUSC cis rs250677 0.522 rs10042466 chr5:148393634 T/C cg18129178 chr5:148520854 ABLIM3 -0.55 -8.07 -0.4 1.3e-14 Breast cancer; LUSC trans rs1994135 0.549 rs2218650 chr12:33734783 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.38 0.33 5.81e-10 Resting heart rate; LUSC cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg03812724 chr21:15588363 RBM11 0.43 6.24 0.32 1.3e-9 Bladder cancer; LUSC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg10802521 chr3:52805072 NEK4 -0.53 -8.57 -0.42 3.93e-16 Bipolar disorder; LUSC cis rs151234 0.741 rs10521145 chr16:28596884 A/G cg01378222 chr16:28622494 SULT1A1 0.59 8.21 0.41 4.72e-15 Platelet distribution width; LUSC cis rs8027181 0.839 rs9460 chr15:73044575 C/T cg25632853 chr15:73088954 NA 0.31 6.32 0.33 8.51e-10 Triglyceride levels; LUSC cis rs7582180 0.676 rs11691135 chr2:100934038 C/T cg12002119 chr2:101014098 CHST10 0.35 5.71 0.3 2.47e-8 Intelligence (multi-trait analysis); LUSC cis rs4654899 0.931 rs2275468 chr1:21220375 T/G cg01072550 chr1:21505969 NA 0.52 7.72 0.39 1.32e-13 Superior frontal gyrus grey matter volume; LUSC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg06212747 chr3:49208901 KLHDC8B 0.43 5.76 0.3 1.95e-8 Parkinson's disease; LUSC cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg05347473 chr6:146136440 FBXO30 -0.48 -8.1 -0.41 1.01e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.74 0.78 8.36e-70 Height; LUSC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg26659404 chr1:25747437 RHCE -0.29 -6.13 -0.32 2.49e-9 Erythrocyte sedimentation rate; LUSC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg00810483 chr4:3375144 RGS12 0.3 5.83 0.3 1.28e-8 Serum sulfate level; LUSC cis rs9527 0.590 rs1541213 chr10:104885330 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC trans rs11098499 0.863 rs10034450 chr4:120455649 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs10504073 0.669 rs57085792 chr8:50018355 T/C cg00325661 chr8:49890786 NA 0.62 10.39 0.49 4.27e-22 Blood metabolite ratios; LUSC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11890956 chr21:40555474 PSMG1 1.0 17.97 0.7 5.22e-51 Cognitive function; LUSC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg23630131 chr7:65973040 NA 0.2 5.68 0.3 2.95e-8 Aortic root size; LUSC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg00599273 chr12:58146742 CDK4 0.31 5.81 0.3 1.48e-8 Multiple sclerosis; LUSC cis rs77372450 0.636 rs10066519 chr5:157017429 A/G cg25387487 chr5:157003181 ADAM19 -0.47 -5.67 -0.3 3.05e-8 Bipolar disorder (body mass index interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24259688 chr15:91414844 FURIN 0.45 6.53 0.34 2.46e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg24675658 chr1:53192096 ZYG11B -0.59 -9.23 -0.45 3.2e-18 Monocyte count; LUSC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg12463550 chr7:65579703 CRCP 0.53 7.59 0.38 3.29e-13 Aortic root size; LUSC cis rs10845606 1.000 rs10845605 chr12:12833468 T/C cg04607235 chr12:12878440 APOLD1 -0.48 -5.67 -0.3 3.1e-8 Systemic lupus erythematosus; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg16031515 chr1:205743344 RAB7L1 -0.3 -6.36 -0.33 6.52e-10 Menarche (age at onset); LUSC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC cis rs1577917 0.883 rs1415749 chr6:86779084 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.41 5.95 0.31 6.89e-9 Response to antipsychotic treatment; LUSC cis rs2996428 0.561 rs2275827 chr1:3746585 T/G cg13057898 chr1:3703894 LRRC47 0.48 8.12 0.41 9.34e-15 Red cell distribution width; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg07507251 chr3:52567010 NT5DC2 0.37 7.63 0.39 2.49e-13 Electroencephalogram traits; LUSC cis rs1670533 0.872 rs10017931 chr4:1060747 G/A cg02018176 chr4:1364513 KIAA1530 0.41 5.65 0.3 3.44e-8 Recombination rate (females); LUSC cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.64e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg14159672 chr1:205819179 PM20D1 0.98 21.07 0.76 2.86e-63 Menarche (age at onset); LUSC cis rs72781680 0.898 rs55841168 chr2:24007926 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs12891047 0.840 rs72725103 chr14:68297100 G/T cg20999565 chr14:68265668 ZFYVE26 0.38 5.8 0.3 1.54e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2708977 0.671 rs582014 chr2:97075826 A/G cg01950434 chr2:97203154 ARID5A -0.45 -6.24 -0.32 1.36e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC trans rs11165623 0.564 rs7523597 chr1:97000989 A/G cg10631902 chr5:14652156 NA -0.41 -6.06 -0.31 3.69e-9 Hip circumference;Waist circumference; LUSC cis rs4319547 0.695 rs7301515 chr12:122949673 T/C cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.6 -0.43 3.09e-16 Body mass index; LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg18963800 chr10:38644991 HSD17B7P2 -0.51 -7.47 -0.38 6.88e-13 Breast cancer; LUSC cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg25427524 chr10:38739819 LOC399744 -0.57 -10.02 -0.48 7.76e-21 Extrinsic epigenetic age acceleration; LUSC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg22800045 chr5:56110881 MAP3K1 0.47 6.33 0.33 7.67e-10 Coronary artery disease; LUSC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg02269571 chr22:50332266 NA 0.59 8.71 0.43 1.44e-16 Schizophrenia; LUSC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg02487422 chr3:49467188 NICN1 0.47 7.56 0.38 3.83e-13 Resting heart rate; LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg16647868 chr5:131706066 SLC22A5 0.38 5.87 0.31 1.07e-8 Breast cancer; LUSC cis rs2688608 0.592 rs7923045 chr10:75487498 A/T cg17411546 chr10:75410026 SYNPO2L -0.5 -7.63 -0.39 2.4e-13 Inflammatory bowel disease; LUSC cis rs9486719 0.947 rs12208556 chr6:96903486 C/T cg06623918 chr6:96969491 KIAA0776 -0.76 -9.58 -0.46 2.23e-19 Migraine;Coronary artery disease; LUSC trans rs12579753 1.000 rs12366580 chr12:82222784 G/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.43 -0.33 4.54e-10 Resting heart rate; LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg14004847 chr7:1930337 MAD1L1 -0.53 -8.07 -0.4 1.31e-14 Bipolar disorder and schizophrenia; LUSC cis rs826838 0.904 rs11612004 chr12:39204282 G/A cg26384229 chr12:38710491 ALG10B 0.89 16.68 0.67 7.5e-46 Heart rate; LUSC cis rs11997175 0.595 rs7386404 chr8:33762842 T/C ch.8.33884649F chr8:33765107 NA 0.43 6.14 0.32 2.4e-9 Body mass index; LUSC cis rs12210905 0.925 rs17345718 chr6:26964258 A/G cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC trans rs12310956 0.532 rs10844712 chr12:33961022 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.98 0.51 3.77e-24 Morning vs. evening chronotype; LUSC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs11190604 1.000 rs11190597 chr10:102293676 A/T cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7599312 0.534 rs2128321 chr2:213405276 G/T cg20637307 chr2:213403960 ERBB4 0.44 7.67 0.39 1.85e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg03806693 chr22:41940476 POLR3H -0.87 -12.28 -0.56 7.15e-29 Vitiligo; LUSC trans rs11098499 0.863 rs1480936 chr4:120462861 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.75 0.39 1.12e-13 Corneal astigmatism; LUSC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg05084668 chr3:125655381 ALG1L -0.5 -7.07 -0.36 9.09e-12 Blood pressure (smoking interaction); LUSC cis rs6977660 0.714 rs7798760 chr7:19803487 T/C cg05791153 chr7:19748676 TWISTNB 0.68 7.28 0.37 2.43e-12 Thyroid stimulating hormone; LUSC cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg13535736 chr9:111863775 C9orf5 -0.4 -6.6 -0.34 1.59e-10 Menarche (age at onset); LUSC cis rs11229555 0.645 rs11229489 chr11:58244917 A/G cg15696309 chr11:58395628 NA -0.71 -8.55 -0.42 4.53e-16 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2625529 0.652 rs2930069 chr15:72226977 G/A cg16672083 chr15:72433130 SENP8 0.49 8.12 0.41 8.94e-15 Red blood cell count; LUSC cis rs12711979 0.584 rs11694096 chr2:3868113 G/A cg17052675 chr2:3827356 NA -0.64 -12.82 -0.57 7.35e-31 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.62 -8.05 -0.4 1.49e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg25036284 chr2:26402008 FAM59B 0.72 9.28 0.45 2.27e-18 Gut microbiome composition (summer); LUSC cis rs7119 0.717 rs12904348 chr15:77815738 G/C cg27398640 chr15:77910606 LINGO1 -0.32 -6.84 -0.35 3.81e-11 Type 2 diabetes; LUSC cis rs838147 0.760 rs412712 chr19:49234299 A/T cg21064579 chr19:49206444 FUT2 -0.33 -5.68 -0.3 2.91e-8 Dietary macronutrient intake; LUSC cis rs4780355 1.000 rs4780355 chr16:11347858 T/C cg00044050 chr16:11439710 C16orf75 0.51 7.3 0.37 2.08e-12 Crohn's disease and psoriasis; LUSC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg03526776 chr6:41159608 TREML2 0.32 6.12 0.32 2.68e-9 Alzheimer's disease (late onset); LUSC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg02353165 chr6:42928485 GNMT 0.48 6.58 0.34 1.83e-10 Blood protein levels; LUSC cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs503341 0.756 rs480874 chr11:63591965 A/T cg04850017 chr11:63683019 RCOR2 0.29 5.79 0.3 1.6e-8 Pulse pressure; LUSC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg14664628 chr15:75095509 CSK -0.55 -8.4 -0.42 1.26e-15 Breast cancer; LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg10729496 chr3:10149963 C3orf24 0.55 7.59 0.38 3.3e-13 Alzheimer's disease; LUSC cis rs9547692 0.938 rs12427600 chr13:37460648 C/T cg01493522 chr13:37497338 NA 0.42 6.48 0.33 3.37e-10 Coronary artery disease; LUSC cis rs9479482 0.648 rs912558 chr6:150385730 G/T cg25797454 chr6:150327115 RAET1K -0.28 -6.3 -0.33 9.14e-10 Alopecia areata; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg05170515 chr14:24899109 CBLN3;KHNYN -0.35 -5.95 -0.31 6.75e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.15 15.59 0.65 1.5e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg22166914 chr1:53195759 ZYG11B 0.48 7.61 0.38 2.74e-13 Monocyte count; LUSC cis rs62432291 0.681 rs425906 chr6:159657575 C/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.64e-9 Joint mobility (Beighton score); LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg02245743 chr17:8114003 AURKB 0.42 6.52 0.34 2.6200000000000003e-10 Educational attainment (years of education); LUSC cis rs6700896 0.931 rs12042807 chr1:66134052 T/C cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs4664304 0.629 rs955388 chr2:160837921 A/G cg05371993 chr16:1458494 UNKL 0.41 5.96 0.31 6.59e-9 Crohn's disease;Inflammatory bowel disease; LUSC trans rs61931739 0.500 rs7979769 chr12:34509522 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.25e-22 Morning vs. evening chronotype; LUSC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg14829155 chr15:31115871 NA 0.64 9.38 0.46 1.02e-18 Huntington's disease progression; LUSC cis rs13108904 0.870 rs3733338 chr4:1241472 G/A cg16405210 chr4:1374714 KIAA1530 -0.54 -8.4 -0.42 1.27e-15 Obesity-related traits; LUSC cis rs12220238 1.000 rs10824078 chr10:75892120 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.14 0.36 5.91e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.63 0.6 5.91e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2742417 0.603 rs2064063 chr3:45759924 T/A cg04837898 chr3:45731254 SACM1L -0.44 -7.19 -0.37 4.38e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs877282 0.945 rs11253396 chr10:789754 C/T cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs7215564 0.908 rs2316062 chr17:78663558 C/T cg09596252 chr17:78655493 RPTOR 0.53 5.85 0.31 1.15e-8 Myopia (pathological); LUSC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg05425664 chr17:57184151 TRIM37 0.55 8.14 0.41 7.84e-15 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11890956 chr21:40555474 PSMG1 1.02 18.56 0.71 2.49e-53 Cognitive function; LUSC cis rs2708977 0.666 rs17685664 chr2:97315570 C/T cg01950434 chr2:97203154 ARID5A 0.53 7.9 0.4 4.01e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs710216 0.917 rs3754223 chr1:43419091 A/T cg03128534 chr1:43423976 SLC2A1 0.43 5.91 0.31 8.51e-9 Red cell distribution width; LUSC cis rs17401966 0.522 rs7368073 chr1:10314962 G/T cg19773385 chr1:10388646 KIF1B -0.34 -5.95 -0.31 6.59e-9 Hepatocellular carcinoma; LUSC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg10792982 chr14:105748885 BRF1 0.52 9.43 0.46 7.25e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg27446573 chr6:127587934 RNF146 0.92 15.4 0.64 8.35e-41 Breast cancer; LUSC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg08132940 chr7:1081526 C7orf50 -0.47 -6.02 -0.31 4.64e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg09365446 chr1:150670422 GOLPH3L 0.47 7.05 0.36 1.02e-11 Melanoma; LUSC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg13206674 chr6:150067644 NUP43 0.58 9.24 0.45 3.02e-18 Lung cancer; LUSC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg13647721 chr17:30228624 UTP6 0.59 5.84 0.3 1.21e-8 Hip circumference adjusted for BMI; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg00024416 chr22:24240387 NA -0.33 -5.67 -0.3 3.09e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -12.07 -0.55 4.24e-28 Platelet count; LUSC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg07936489 chr17:37558343 FBXL20 0.69 9.58 0.46 2.38e-19 Glomerular filtration rate (creatinine); LUSC cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg18964960 chr10:1102726 WDR37 -0.44 -5.93 -0.31 7.47e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11890956 chr21:40555474 PSMG1 -0.72 -11.24 -0.52 4.47e-25 Menarche (age at onset); LUSC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg03929089 chr4:120376271 NA 0.94 14.98 0.63 3.51e-39 Coronary artery disease; LUSC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg00033643 chr7:134001901 SLC35B4 0.42 6.58 0.34 1.77e-10 Mean platelet volume; LUSC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg12365402 chr11:9010492 NRIP3 -0.49 -9.37 -0.46 1.15e-18 Hemoglobin concentration; LUSC cis rs977987 0.843 rs10514396 chr16:75422903 T/C cg03315344 chr16:75512273 CHST6 0.53 10.35 0.49 6.07e-22 Dupuytren's disease; LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg19318889 chr4:1322082 MAEA 0.47 7.64 0.39 2.28e-13 Obesity-related traits; LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg22143856 chr6:28129313 ZNF389 0.42 5.78 0.3 1.73e-8 Parkinson's disease; LUSC cis rs9311676 0.656 rs4681682 chr3:58337833 A/G cg13750441 chr3:58318267 PXK -0.32 -6.08 -0.32 3.19e-9 Systemic lupus erythematosus; LUSC cis rs72781680 1.000 rs963725 chr2:24148231 T/C cg08917208 chr2:24149416 ATAD2B 1.01 10.61 0.5 7.29e-23 Lymphocyte counts; LUSC cis rs2439831 1.000 rs2601014 chr15:43756013 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.93 9.99 0.48 9.57e-21 Lung cancer in ever smokers; LUSC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg18404041 chr3:52824283 ITIH1 -0.52 -9.82 -0.47 3.77e-20 Bipolar disorder; LUSC cis rs10464366 0.560 rs11763728 chr7:39145862 C/T cg18850127 chr7:39170497 POU6F2 0.58 9.17 0.45 4.96e-18 IgG glycosylation; LUSC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg17264618 chr3:40429014 ENTPD3 0.35 7.19 0.37 4.15e-12 Renal cell carcinoma; LUSC cis rs9790314 0.967 rs7623206 chr3:160971518 G/A cg03342759 chr3:160939853 NMD3 -0.51 -8.5 -0.42 6.58e-16 Morning vs. evening chronotype; LUSC cis rs12681288 0.576 rs6990403 chr8:963471 C/A cg15309053 chr8:964076 NA 0.39 7.57 0.38 3.7e-13 Schizophrenia; LUSC cis rs8062405 1.000 rs61737565 chr16:28855522 G/C cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7824557 0.675 rs2736265 chr8:11186674 A/G cg21775007 chr8:11205619 TDH 0.83 13.49 0.59 2.12e-33 Retinal vascular caliber; LUSC trans rs7824557 0.843 rs2736375 chr8:11115749 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -7.01 -0.36 1.31e-11 Retinal vascular caliber; LUSC cis rs722599 0.748 rs3742783 chr14:75377008 C/T cg06637938 chr14:75390232 RPS6KL1 -0.41 -6.05 -0.31 3.9e-9 IgG glycosylation; LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.42 5.95 0.31 6.93e-9 Renal function-related traits (BUN); LUSC cis rs2414856 0.510 rs72756980 chr15:64574780 G/A cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs1712517 0.771 rs61869827 chr10:105079439 T/C cg05636881 chr10:105038444 INA 0.39 6.39 0.33 5.47e-10 Migraine; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.54 0.76 3.92e-65 Prudent dietary pattern; LUSC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.7 0.34 8.76e-11 Depression; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00360718 chr10:104192479 CUEDC2 -0.48 -6.23 -0.32 1.43e-9 Hepatitis; LUSC trans rs2229238 0.911 rs73020232 chr1:154482669 C/T cg25273160 chr11:56955011 LRRC55 0.31 5.96 0.31 6.37e-9 Coronary heart disease; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg08736216 chr1:53307985 ZYG11A -0.3 -6.05 -0.31 3.82e-9 Monocyte count; LUSC cis rs1215050 0.765 rs783925 chr4:98969881 T/C cg05340658 chr4:99064831 C4orf37 -0.47 -7.43 -0.38 8.98e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs16866061 1.000 rs34345163 chr2:225459080 A/G cg12698349 chr2:225449008 CUL3 0.85 13.68 0.6 4.04e-34 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg09359103 chr1:154839909 KCNN3 0.72 16.13 0.66 1.06e-43 Prostate cancer; LUSC cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg16240275 chr20:61666158 NCRNA00029 0.42 8.89 0.44 3.82e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs1775715 0.677 rs2491272 chr10:32186783 A/G cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.65e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg06634786 chr22:41940651 POLR3H -0.53 -6.47 -0.33 3.45e-10 Vitiligo; LUSC cis rs2970818 0.831 rs2970812 chr12:4625836 C/T cg11146114 chr12:4671731 NA -0.59 -6.33 -0.33 7.79e-10 Phosphorus levels; LUSC cis rs17253792 0.822 rs75555677 chr14:56096429 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs72781680 0.651 rs13019016 chr2:23894773 C/G cg20701182 chr2:24300061 SF3B14 0.57 5.89 0.31 9.57e-9 Lymphocyte counts; LUSC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs28785552 0.897 rs34244888 chr19:53242228 T/A cg22067481 chr19:53234126 ZNF611 -0.53 -7.36 -0.37 1.4e-12 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg11494091 chr17:61959527 GH2 0.63 13.38 0.59 5.59e-33 Prudent dietary pattern; LUSC cis rs56399783 0.803 rs7811164 chr7:2822416 G/A cg14895029 chr7:2775587 GNA12 0.47 5.92 0.31 7.95e-9 Childhood ear infection; LUSC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 2.98e-10 Life satisfaction; LUSC cis rs5771069 0.897 rs137858 chr22:50445601 T/C cg27068297 chr22:50451975 IL17REL 0.29 6.07 0.32 3.53e-9 Ulcerative colitis; LUSC cis rs3126085 0.935 rs4511113 chr1:152222192 G/A cg26876637 chr1:152193138 HRNR 0.45 6.19 0.32 1.73e-9 Atopic dermatitis; LUSC cis rs11190604 1.000 rs3750720 chr10:102248884 C/T cg07080220 chr10:102295463 HIF1AN 0.62 7.79 0.39 8.78e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6964587 1.000 rs11772102 chr7:91558326 A/T cg17063962 chr7:91808500 NA -0.55 -8.63 -0.43 2.47e-16 Breast cancer; LUSC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg19230755 chr7:65878503 NA 0.43 5.97 0.31 6.12e-9 Aortic root size; LUSC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg16049864 chr8:95962084 TP53INP1 -0.72 -14.25 -0.61 2.59e-36 Type 2 diabetes; LUSC cis rs7760949 0.888 rs9296853 chr6:13893945 T/A cg27413430 chr6:13925136 RNF182 0.53 7.89 0.4 4.25e-14 Mean corpuscular hemoglobin concentration; LUSC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.14 -0.8 3.2e-75 Height; LUSC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg00800038 chr16:89945340 TCF25 -0.76 -6.58 -0.34 1.78e-10 Skin colour saturation; LUSC cis rs3820928 1.000 rs4675119 chr2:227774635 A/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.9 -0.4 3.95e-14 Pulmonary function; LUSC cis rs7584330 0.554 rs112402109 chr2:238429058 A/G cg14458575 chr2:238380390 NA 0.46 5.76 0.3 1.95e-8 Prostate cancer; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg16876192 chr8:144550601 ZC3H3 -0.39 -6.02 -0.31 4.52e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC trans rs877282 1.000 rs11253367 chr10:773389 G/A cg13042288 chr15:90349979 ANPEP -0.49 -7.01 -0.36 1.34e-11 Uric acid levels; LUSC cis rs459571 1.000 rs459571 chr9:136912626 C/T cg13789015 chr9:136890014 NCRNA00094 0.7 13.0 0.58 1.45e-31 Platelet distribution width; LUSC cis rs12760731 0.565 rs10913519 chr1:178196094 A/T cg00404053 chr1:178313656 RASAL2 0.68 6.9 0.35 2.55e-11 Obesity-related traits; LUSC cis rs9905704 0.918 rs11655808 chr17:56854517 T/C cg12560992 chr17:57184187 TRIM37 0.54 7.55 0.38 4.22e-13 Testicular germ cell tumor; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg07424592 chr7:64974309 NA -0.45 -6.42 -0.33 4.78e-10 Calcium levels; LUSC cis rs356992 0.915 rs356977 chr2:60748758 A/G cg08426369 chr2:60753602 BCL11A 0.4 5.65 0.3 3.47e-8 Educational attainment (years of education); LUSC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg13798780 chr7:105162888 PUS7 0.56 6.08 0.32 3.26e-9 Bipolar disorder (body mass index interaction); LUSC cis rs17783634 0.509 rs11775489 chr8:11036843 T/C cg21775007 chr8:11205619 TDH -0.47 -6.51 -0.34 2.7e-10 Subjective well-being; LUSC cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.64e-13 Aortic root size; LUSC cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.12 -0.45 7.17e-18 Schizophrenia; LUSC cis rs9309473 0.898 rs7587577 chr2:73832786 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -6.3 -0.33 9.52e-10 Metabolite levels; LUSC trans rs8072100 1.000 rs8065437 chr17:45721653 C/T cg03886242 chr7:26192032 NFE2L3 -0.38 -6.36 -0.33 6.45e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6964587 1.000 rs2282972 chr7:91666369 C/T cg01689657 chr7:91764605 CYP51A1 0.32 5.71 0.3 2.44e-8 Breast cancer; LUSC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs117623576 1.000 rs117623576 chr10:32387808 C/T cg03047570 chr10:32398778 NA -0.71 -6.72 -0.35 7.85e-11 Anti-saccade response; LUSC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs616402 0.564 rs7419116 chr1:10578606 G/A cg17425144 chr1:10567563 PEX14 0.66 13.59 0.6 8.94e-34 Breast size; LUSC cis rs3768617 0.510 rs4651140 chr1:183096952 G/T ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs2970818 0.764 rs4323977 chr12:4615481 C/T cg11146114 chr12:4671731 NA 0.58 5.9 0.31 9.04e-9 Phosphorus levels; LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg27535305 chr1:53392650 SCP2 -0.4 -7.57 -0.38 3.57e-13 Monocyte count; LUSC cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg18681998 chr4:17616180 MED28 0.86 15.34 0.64 1.39e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg23985595 chr17:80112537 CCDC57 -0.3 -5.72 -0.3 2.32e-8 Life satisfaction; LUSC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg00484396 chr16:3507460 NAT15 0.68 12.12 0.55 2.93e-28 Tuberculosis; LUSC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg24209194 chr3:40518798 ZNF619 -0.41 -5.74 -0.3 2.14e-8 Renal cell carcinoma; LUSC trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg15556689 chr8:8085844 FLJ10661 -0.54 -8.52 -0.42 5.44e-16 Retinal vascular caliber; LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg11266682 chr4:10021025 SLC2A9 0.49 9.11 0.45 7.9e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7089973 0.934 rs68085797 chr10:116632130 A/T cg23260525 chr10:116636907 FAM160B1 0.39 7.38 0.37 1.31e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9486715 0.867 rs12207471 chr6:96963782 A/G cg06623918 chr6:96969491 KIAA0776 0.93 17.02 0.68 3.36e-47 Headache; LUSC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg23887609 chr12:130822674 PIWIL1 0.49 7.34 0.37 1.64e-12 Menopause (age at onset); LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg21782813 chr7:2030301 MAD1L1 0.44 7.19 0.37 4.32e-12 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg20503657 chr10:835505 NA 0.99 14.19 0.61 4.28e-36 Eosinophil percentage of granulocytes; LUSC trans rs4843747 0.708 rs11866437 chr16:88072279 A/G cg26811252 chr16:29126840 RRN3P2 -0.59 -9.69 -0.47 9.61e-20 Menopause (age at onset); LUSC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs921968 0.565 rs7573999 chr2:219601392 A/G cg02176678 chr2:219576539 TTLL4 -0.57 -9.98 -0.48 1.06e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg09835421 chr16:68378352 PRMT7 -0.55 -6.22 -0.32 1.45e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.5 -7.02 -0.36 1.24e-11 Gut microbiome composition (summer); LUSC cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg24642439 chr20:33292090 TP53INP2 0.5 7.56 0.38 3.9e-13 Height; LUSC cis rs9611519 1.000 rs9611510 chr22:41569124 T/C cg13813247 chr22:41461852 NA -0.36 -6.52 -0.34 2.59e-10 Neuroticism; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg23131131 chr22:24373011 LOC391322 -0.51 -7.4 -0.38 1.08e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg26384229 chr12:38710491 ALG10B 0.88 14.94 0.63 5.21e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs7582180 0.652 rs11687865 chr2:100947000 T/A cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs79387448 0.626 rs80277428 chr2:103080056 G/A cg09003973 chr2:102972529 NA 1.08 10.62 0.5 6.86e-23 Gut microbiota (bacterial taxa); LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.53 0.46 3.39e-19 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg05340658 chr4:99064831 C4orf37 0.67 11.44 0.53 8.41e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg06671706 chr8:8559999 CLDN23 0.49 6.61 0.34 1.48e-10 Obesity-related traits; LUSC cis rs78707713 0.592 rs3829182 chr10:71251384 A/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.55 -0.46 2.85e-19 Venous thromboembolism; LUSC cis rs5758511 0.689 rs56906457 chr22:42628335 A/G cg00645731 chr22:42541494 CYP2D7P1 0.55 8.8 0.43 7.65e-17 Birth weight; LUSC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg03354898 chr7:1950403 MAD1L1 -0.31 -5.78 -0.3 1.7e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg08736216 chr1:53307985 ZYG11A 0.29 6.03 0.31 4.36e-9 Monocyte count; LUSC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg05785598 chr3:49045655 WDR6 0.33 5.84 0.3 1.23e-8 Parkinson's disease; LUSC cis rs2637266 1.000 rs2395390 chr10:78357734 C/G cg18941641 chr10:78392320 NA 0.39 7.04 0.36 1.1e-11 Pulmonary function; LUSC cis rs73200209 0.703 rs57060349 chr12:116579304 T/C cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs9467773 0.620 rs2504565 chr6:26656890 G/A cg11502198 chr6:26597334 ABT1 0.73 12.28 0.56 7.5e-29 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.84 -0.44 5.48e-17 Chronic sinus infection; LUSC cis rs9329221 0.521 rs17693945 chr8:10106010 C/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.17 -0.32 1.95e-9 Neuroticism; LUSC cis rs71403859 0.730 rs12446333 chr16:71752157 T/C cg08717414 chr16:71523259 ZNF19 -0.65 -7.13 -0.36 6.35e-12 Post bronchodilator FEV1; LUSC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg16339924 chr4:17578868 LAP3 0.63 9.88 0.48 2.3e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15135638 chr3:183947356 VWA5B2 -0.43 -6.39 -0.33 5.58e-10 Electrocardiographic conduction measures; LUSC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg03289416 chr15:75166202 SCAMP2 0.43 6.89 0.35 2.86e-11 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09766628 chr17:4634728 MED11 0.46 6.64 0.34 1.26e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg26260369 chr14:68141723 VTI1B 0.39 6.43 0.33 4.47e-10 Triglycerides; LUSC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg04450456 chr4:17643702 FAM184B 0.39 6.67 0.34 1.09e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg06784218 chr1:46089804 CCDC17 0.53 11.02 0.52 2.64e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg25767906 chr1:53392781 SCP2 0.4 6.91 0.35 2.48e-11 Monocyte count; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg12595647 chr1:54411915 LRRC42;HSPB11 -0.45 -6.2 -0.32 1.71e-9 Hepatitis; LUSC cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg05347473 chr6:146136440 FBXO30 -0.47 -7.9 -0.4 4.12e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11777782 chr19:18284937 IFI30 0.45 6.48 0.33 3.37e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg17724175 chr1:150552817 MCL1 0.31 5.66 0.3 3.21e-8 Melanoma; LUSC cis rs11630290 0.592 rs12594446 chr15:64156674 G/T cg12036633 chr15:63758958 NA 0.52 6.64 0.34 1.26e-10 Iris characteristics; LUSC cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg02450064 chr17:40260053 DHX58 0.47 6.41 0.33 4.97e-10 Fibrinogen levels; LUSC cis rs9560113 0.509 rs4771759 chr13:112209217 A/G cg10483660 chr13:112241077 NA -0.41 -7.04 -0.36 1.07e-11 Menarche (age at onset); LUSC cis rs12940923 1.000 rs11659092 chr17:56364269 C/T cg19466818 chr17:56409534 MIR142 -0.39 -6.86 -0.35 3.35e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg18230493 chr5:56204884 C5orf35 -0.68 -10.44 -0.5 2.79e-22 Coronary artery disease; LUSC cis rs4343996 0.566 rs4236326 chr7:3400105 C/T cg21248987 chr7:3385318 SDK1 -0.34 -5.76 -0.3 1.9e-8 Motion sickness; LUSC cis rs7582180 0.602 rs7585582 chr2:100998030 G/C cg08017756 chr2:100939284 LONRF2 -0.4 -7.4 -0.38 1.1e-12 Intelligence (multi-trait analysis); LUSC cis rs3092073 0.669 rs11697323 chr20:44551579 C/T cg17986701 chr20:44574422 PCIF1 0.37 6.55 0.34 2.22e-10 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg18827107 chr12:86230957 RASSF9 0.45 6.86 0.35 3.4e-11 Major depressive disorder; LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.44 6.02 0.31 4.65e-9 Platelet count; LUSC cis rs911119 0.955 rs59059917 chr20:23595675 C/T cg16589663 chr20:23618590 CST3 0.62 7.44 0.38 8.74e-13 Chronic kidney disease; LUSC trans rs208520 0.526 rs9363522 chr6:66816642 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.22 -25.58 -0.81 1.12e-80 Exhaled nitric oxide output; LUSC cis rs9467711 0.606 rs9379864 chr6:26372584 G/A cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -7.96 -0.4 2.67e-14 Lymphocyte counts; LUSC trans rs11039798 0.623 rs584851 chr11:48416321 A/G cg15704280 chr7:45808275 SEPT13 -0.67 -6.31 -0.33 8.99e-10 Axial length; LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4363385 0.934 rs6667418 chr1:152969685 A/G cg00922841 chr1:152955080 SPRR1A -0.49 -8.33 -0.41 2.17e-15 Inflammatory skin disease; LUSC cis rs11608355 0.846 rs60945232 chr12:109854401 A/G cg19025524 chr12:109796872 NA -0.39 -5.72 -0.3 2.35e-8 Neuroticism; LUSC cis rs929354 0.713 rs6946660 chr7:156948648 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg11062466 chr8:58055876 NA 0.5 6.57 0.34 1.89e-10 Developmental language disorder (linguistic errors); LUSC cis rs1801251 1.000 rs9653383 chr2:233670380 A/C cg08000102 chr2:233561755 GIGYF2 -0.72 -11.79 -0.54 4.76e-27 Coronary artery disease; LUSC trans rs2975734 0.680 rs10503406 chr8:10108972 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.21 -0.32 1.61e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg16647868 chr5:131706066 SLC22A5 0.4 6.12 0.32 2.6e-9 Breast cancer; LUSC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg05025164 chr4:1340916 KIAA1530 0.4 5.91 0.31 8.66e-9 Obesity-related traits; LUSC cis rs977987 0.806 rs1549306 chr16:75415341 A/G cg04384234 chr16:75411784 CFDP1 -0.4 -6.68 -0.34 9.74e-11 Dupuytren's disease; LUSC cis rs7119 0.717 rs8042307 chr15:77804013 A/G cg27398640 chr15:77910606 LINGO1 -0.29 -6.2 -0.32 1.7e-9 Type 2 diabetes; LUSC cis rs1997103 1.000 rs2177803 chr7:55410773 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6845621 0.745 rs16897766 chr4:18869945 A/G cg12196642 chr4:18937545 NA -0.32 -6.0 -0.31 5.11e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg24692254 chr21:30365293 RNF160 -0.82 -15.21 -0.64 4.55e-40 Dental caries; LUSC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11644478 chr21:40555479 PSMG1 0.95 18.99 0.72 4.85e-55 Cognitive function; LUSC cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.72 0.43 1.29e-16 Menopause (age at onset); LUSC cis rs11098499 0.866 rs12374244 chr4:120281972 A/T cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.85 0.44 5.14e-17 Schizophrenia; LUSC cis rs4132509 0.744 rs59953491 chr1:243894953 C/T cg21452805 chr1:244014465 NA 0.63 6.97 0.36 1.75e-11 RR interval (heart rate); LUSC cis rs765787 0.530 rs4238376 chr15:45541887 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.04e-16 Uric acid levels; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg07157834 chr1:205819609 PM20D1 0.99 21.68 0.76 1.07e-65 Menarche (age at onset); LUSC cis rs9837602 0.872 rs1489816 chr3:99769088 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -5.71 -0.3 2.48e-8 Breast cancer; LUSC cis rs4908769 0.624 rs301789 chr1:8469337 A/G cg00546117 chr1:8445545 RERE -0.28 -5.65 -0.3 3.37e-8 Allergy; LUSC cis rs1865721 1.000 rs72977879 chr18:73193696 T/C cg26385618 chr18:73139727 C18orf62 -0.48 -8.1 -0.41 1.04e-14 Intelligence; LUSC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg18230493 chr5:56204884 C5orf35 -0.67 -10.6 -0.5 8.02e-23 Coronary artery disease; LUSC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.43 -6.95 -0.36 1.93e-11 Alzheimer's disease (late onset); LUSC cis rs9300255 0.543 rs1260294 chr12:123560289 T/C cg13010344 chr12:123464640 ARL6IP4 0.54 6.67 0.34 1.06e-10 Neutrophil percentage of white cells; LUSC cis rs3760047 0.609 rs2541639 chr16:205035 C/T cg08400316 chr16:204221 HBZ 0.55 6.88 0.35 2.9e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg13722127 chr7:150037890 RARRES2 0.4 5.99 0.31 5.48e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg13852791 chr20:30311386 BCL2L1 0.91 12.42 0.56 2.22e-29 Mean corpuscular hemoglobin; LUSC cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -12.21 -0.56 1.35e-28 Chronic sinus infection; LUSC cis rs6596100 0.538 rs113848378 chr5:132192372 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.02 -0.31 4.6e-9 Breast cancer; LUSC cis rs12908161 0.959 rs17534709 chr15:85314397 G/C cg17507749 chr15:85114479 UBE2QP1 0.5 5.98 0.31 5.75e-9 Schizophrenia; LUSC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg15556689 chr8:8085844 FLJ10661 0.67 11.32 0.53 2.22e-25 Systolic blood pressure; LUSC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg12560992 chr17:57184187 TRIM37 -0.85 -15.52 -0.65 2.75e-41 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg04025307 chr7:1156635 C7orf50 0.42 5.87 0.31 1.07e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs61931739 0.500 rs11053271 chr12:34545407 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs1801251 0.778 rs709934 chr2:233733352 A/G cg25237894 chr2:233734115 C2orf82 -0.34 -6.5 -0.34 2.95e-10 Coronary artery disease; LUSC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg24324837 chr19:49891574 CCDC155 0.56 7.72 0.39 1.41e-13 Multiple sclerosis; LUSC cis rs3768617 0.811 rs4285667 chr1:182970225 T/A ch.1.3577855R chr1:183094577 LAMC1 0.57 8.25 0.41 3.64e-15 Fuchs's corneal dystrophy; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg09409496 chr21:38738374 DYRK1A 0.4 6.09 0.32 3.06e-9 Mosquito bite size; LUSC cis rs9309473 0.948 rs13391552 chr2:73818936 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -6.4 -0.33 5.22e-10 Metabolite levels; LUSC cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.47 6.28 0.32 1.08e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4953404 0.613 rs6734725 chr2:46897570 G/A cg09399716 chr2:46890238 NA -0.31 -7.05 -0.36 1.03e-11 Pulse pressure (alcohol consumption interaction); LUSC trans rs7613875 0.620 rs34312088 chr3:50032133 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.49 7.61 0.38 2.77e-13 Body mass index; LUSC cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -9.47 -0.46 5.16e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11051970 0.659 rs904917 chr12:32591302 G/A cg02745156 chr12:32552066 NA 0.38 5.87 0.31 1.05e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4561483 0.801 rs33619 chr16:12008941 T/G cg08843971 chr16:11963173 GSPT1 -0.49 -7.36 -0.37 1.47e-12 Testicular germ cell tumor; LUSC cis rs2944591 0.505 rs2592118 chr2:233792425 C/T cg11972305 chr2:233791962 NGEF -0.33 -6.44 -0.33 4.15e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs793571 0.502 rs411007 chr15:59078502 G/C cg05156742 chr15:59063176 FAM63B 0.55 8.73 0.43 1.22e-16 Schizophrenia; LUSC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg18876405 chr7:65276391 NA 0.55 8.58 0.42 3.72e-16 Aortic root size; LUSC cis rs9420 0.961 rs7936998 chr11:57639017 G/A cg23127183 chr11:57508653 C11orf31 -0.56 -8.39 -0.42 1.37e-15 Schizophrenia; LUSC cis rs2639990 0.744 rs640261 chr18:72905808 C/T cg02750262 chr18:72916776 ZADH2 0.68 7.54 0.38 4.43e-13 Vascular endothelial growth factor levels; LUSC cis rs12101261 0.925 rs2300519 chr14:81458762 T/A cg06600135 chr14:81408086 NA 0.43 6.24 0.32 1.3e-9 Graves' disease; LUSC cis rs7614311 0.681 rs57766205 chr3:63895303 G/C cg22134162 chr3:63841271 THOC7 -0.45 -5.81 -0.3 1.43e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs500891 0.868 rs62419325 chr6:84143892 A/G cg08257003 chr6:84140564 ME1 0.35 7.27 0.37 2.56e-12 Platelet-derived growth factor BB levels; LUSC cis rs644799 0.562 rs1313288 chr11:95520695 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.32 0.45 1.58e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.13 0.41 8.56e-15 Axial length; LUSC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg05535760 chr7:792225 HEATR2 0.93 9.7 0.47 8.89e-20 Cerebrospinal P-tau181p levels; LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg11965913 chr1:205819406 PM20D1 0.59 10.34 0.49 6.33e-22 Menarche (age at onset); LUSC cis rs4363385 0.818 rs10788852 chr1:153000491 C/G cg00922841 chr1:152955080 SPRR1A -0.41 -6.97 -0.36 1.75e-11 Inflammatory skin disease; LUSC cis rs9303401 0.625 rs10515159 chr17:56802693 G/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs2463822 0.748 rs2513038 chr11:62081329 A/C cg06239285 chr11:62104954 ASRGL1 0.95 10.44 0.5 2.94e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs80130819 0.515 rs6580656 chr12:48570604 C/T cg24011408 chr12:48396354 COL2A1 0.47 6.5 0.34 2.93e-10 Prostate cancer; LUSC cis rs4764124 0.571 rs11830399 chr12:14956932 G/C cg19759883 chr12:14956454 WBP11;C12orf60 0.38 5.87 0.31 1.05e-8 Pubertal anthropometrics; LUSC cis rs11167764 0.638 rs7729747 chr5:141478055 C/A cg23435118 chr5:141488016 NDFIP1 -0.58 -7.86 -0.4 5.37e-14 Crohn's disease; LUSC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg17376030 chr22:41985996 PMM1 -0.48 -6.02 -0.31 4.57e-9 Vitiligo; LUSC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11644478 chr21:40555479 PSMG1 0.94 19.08 0.72 1.99e-55 Cognitive function; LUSC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.35 0.46 1.28e-18 Monocyte percentage of white cells; LUSC cis rs11785400 1.000 rs11785400 chr8:143730456 C/T cg24634471 chr8:143751801 JRK 0.6 8.99 0.44 1.83e-17 Schizophrenia; LUSC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 8.51 0.42 6.09e-16 Schizophrenia; LUSC cis rs12220238 1.000 rs115418388 chr10:75976296 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.12e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2637266 0.685 rs7098713 chr10:78452828 C/T cg18941641 chr10:78392320 NA 0.33 5.97 0.31 5.95e-9 Pulmonary function; LUSC trans rs6502050 0.698 rs36043222 chr17:80117822 G/T cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg11266682 chr4:10021025 SLC2A9 -0.56 -10.02 -0.48 7.65e-21 Bone mineral density; LUSC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.27 -0.41 3.33e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs11039798 0.925 rs7929225 chr11:48931739 G/C cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg11812906 chr14:75593930 NEK9 0.65 11.35 0.53 1.79e-25 Height; LUSC cis rs1878931 0.580 rs4785932 chr16:3410456 C/G cg22508957 chr16:3507546 NAT15 -0.37 -6.08 -0.32 3.22e-9 Body mass index (adult); LUSC cis rs859767 0.741 rs11684785 chr2:135393110 C/T cg12500956 chr2:135428796 TMEM163 -0.28 -6.3 -0.33 9.48e-10 Neuroticism; LUSC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs72960926 0.744 rs768509 chr6:75005487 G/A cg03266952 chr6:74778945 NA -0.76 -6.65 -0.34 1.21e-10 Metabolite levels (MHPG); LUSC cis rs12980942 0.872 rs7258749 chr19:41806647 C/T cg25627403 chr19:41769009 HNRNPUL1 0.62 6.77 0.35 5.89e-11 Coronary artery disease; LUSC cis rs7808935 0.789 rs2040668 chr7:27958773 G/T cg22168087 chr7:27702803 HIBADH -0.62 -7.56 -0.38 3.83e-13 Prostate cancer; LUSC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg05855489 chr10:104503620 C10orf26 0.59 9.5 0.46 4.35e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17854409 1.000 rs6011427 chr20:61496680 C/T cg05147244 chr20:61493195 TCFL5 0.9 7.55 0.38 4.07e-13 Obesity-related traits; LUSC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.39 0.49 4.43e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg10523679 chr1:76189770 ACADM -0.81 -11.1 -0.52 1.44e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg00750074 chr16:89608354 SPG7 -0.54 -9.94 -0.48 1.41e-20 Multiple myeloma (IgH translocation); LUSC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg12751644 chr20:60527061 NA -0.34 -5.98 -0.31 5.71e-9 Body mass index; LUSC cis rs662064 0.748 rs2506889 chr1:10596022 C/T cg20482658 chr1:10539492 PEX14 0.32 6.45 0.33 3.89e-10 Asthma; LUSC trans rs11610422 1.000 rs34325065 chr12:31414505 C/G cg02734259 chr12:9559402 NA -0.61 -6.48 -0.33 3.38e-10 Coronary artery disease; LUSC cis rs7267979 0.816 rs374701 chr20:25483616 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.25 0.66 3.75e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs60843830 1.000 rs3791223 chr2:222336 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 10.31 0.49 7.82e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs763121 0.853 rs5750622 chr22:38956464 C/G cg06022373 chr22:39101656 GTPBP1 0.78 12.0 0.55 8.02e-28 Menopause (age at onset); LUSC cis rs11168618 1.000 rs12815544 chr12:48949608 A/G cg24011408 chr12:48396354 COL2A1 0.4 6.29 0.33 9.82e-10 Adiponectin levels; LUSC cis rs1018836 0.739 rs6993715 chr8:91531188 G/C cg16814680 chr8:91681699 NA -0.72 -11.17 -0.52 7.62e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9527 0.590 rs3781282 chr10:104852419 C/T cg23093090 chr10:104574429 C10orf26 0.35 6.6 0.34 1.65e-10 Arsenic metabolism; LUSC cis rs9653442 0.510 rs13415583 chr2:100764087 T/G cg22139774 chr2:100720529 AFF3 -0.42 -7.3 -0.37 2.16e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1670533 1.000 rs604597 chr4:1094151 G/A cg27284194 chr4:1044797 NA -0.56 -8.13 -0.41 8.4e-15 Recombination rate (females); LUSC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.43 -7.11 -0.36 7.28e-12 Hip circumference adjusted for BMI; LUSC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg11764359 chr7:65958608 NA -0.52 -6.78 -0.35 5.48e-11 Aortic root size; LUSC cis rs910873 0.505 rs7261964 chr20:33205011 C/T cg16810054 chr20:33298113 TP53INP2 -0.38 -5.67 -0.3 3.11e-8 Melanoma; LUSC cis rs11690935 0.959 rs10167419 chr2:172649826 A/G cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.86 -0.63 1.03e-38 Schizophrenia; LUSC cis rs9399401 0.961 rs6909857 chr6:142701158 A/G cg03128060 chr6:142623767 GPR126 0.34 6.1 0.32 2.93e-9 Chronic obstructive pulmonary disease; LUSC cis rs9921338 0.961 rs7195536 chr16:11442028 T/C cg00044050 chr16:11439710 C16orf75 -0.51 -6.81 -0.35 4.58e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs709400 0.567 rs28496120 chr14:103897899 C/T cg10523860 chr14:103875565 MARK3 -0.37 -5.8 -0.3 1.55e-8 Body mass index; LUSC trans rs4868731 0.656 rs1421629 chr5:163531125 A/T cg10167512 chr13:112838934 NA -0.33 -6.24 -0.32 1.36e-9 Common carotid intima-media thickness; LUSC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg04369109 chr6:150039330 LATS1 -0.53 -7.86 -0.39 5.51e-14 Lung cancer; LUSC cis rs7267979 0.714 rs6115107 chr20:25237390 A/G cg08601574 chr20:25228251 PYGB 0.48 7.45 0.38 8.3e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.62 0.43 2.77e-16 Menarche (age at onset); LUSC cis rs7267979 1.000 rs1888999 chr20:25291848 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 18.25 0.71 4.01e-52 Liver enzyme levels (alkaline phosphatase); LUSC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg07870213 chr5:140052090 DND1 0.77 11.51 0.53 4.78e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg25319279 chr11:5960081 NA -0.42 -6.38 -0.33 5.82e-10 DNA methylation (variation); LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg08677398 chr8:58056175 NA 0.54 6.39 0.33 5.43e-10 Developmental language disorder (linguistic errors); LUSC cis rs7584330 0.737 rs937392 chr2:238367130 C/T cg14458575 chr2:238380390 NA 0.67 11.78 0.54 5.17e-27 Prostate cancer; LUSC cis rs9902453 0.791 rs3115086 chr17:28025949 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.61 0.54 2.09e-26 Coffee consumption (cups per day); LUSC cis rs240764 0.658 rs35967345 chr6:101187858 T/G cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.51e-10 Neuroticism; LUSC cis rs7582720 1.000 rs72932557 chr2:203846817 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg24812749 chr6:127587940 RNF146 0.92 13.69 0.6 3.62e-34 Breast cancer; LUSC cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg16006841 chr5:176797999 RGS14 0.66 10.58 0.5 9.46e-23 Hemoglobin concentration;Hematocrit; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg00945038 chr17:61921165 SMARCD2 0.53 9.35 0.46 1.3e-18 Prudent dietary pattern; LUSC cis rs7824557 0.767 rs17797443 chr8:11164012 T/C cg27411982 chr8:10470053 RP1L1 0.37 5.87 0.31 1.05e-8 Retinal vascular caliber; LUSC cis rs61931739 1.000 rs11502817 chr12:34010676 T/C cg06521331 chr12:34319734 NA 0.4 6.57 0.34 1.97e-10 Morning vs. evening chronotype; LUSC cis rs6977660 0.941 rs5017197 chr7:19819967 T/A cg07541023 chr7:19748670 TWISTNB 0.51 5.74 0.3 2.14e-8 Thyroid stimulating hormone; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25978167 chr4:57301353 PAICS;PPAT 0.46 6.69 0.34 9.45e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3849570 0.961 rs3772912 chr3:81698481 A/G cg07356753 chr3:81810745 GBE1 -0.49 -7.55 -0.38 4.16e-13 Waist circumference;Body mass index; LUSC trans rs6601327 0.607 rs35316422 chr8:9575129 G/T cg15556689 chr8:8085844 FLJ10661 -0.44 -6.12 -0.32 2.64e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg14019146 chr3:50243930 SLC38A3 -0.37 -8.76 -0.43 1.02e-16 Body mass index; LUSC cis rs782590 0.967 rs17278044 chr2:55748217 G/C cg03859395 chr2:55845619 SMEK2 0.86 16.22 0.66 4.87e-44 Metabolic syndrome; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.73 -0.51 2.92e-23 Alzheimer's disease; LUSC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6088813 0.961 rs6060373 chr20:33914208 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.39 6.38 0.33 5.89e-10 Height; LUSC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg08219700 chr8:58056026 NA 0.49 6.21 0.32 1.59e-9 Developmental language disorder (linguistic errors); LUSC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg15556689 chr8:8085844 FLJ10661 -0.59 -9.12 -0.45 7.16e-18 Mood instability; LUSC cis rs244731 1.000 rs244731 chr5:176539679 C/T cg06060754 chr5:176797920 RGS14 0.67 8.69 0.43 1.71e-16 Urate levels in lean individuals; LUSC cis rs7236492 0.532 rs3786184 chr18:77195885 A/C cg15644404 chr18:77186268 NFATC1 -0.51 -7.02 -0.36 1.27e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6121246 0.529 rs6060195 chr20:30185638 C/T cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg24838063 chr12:130822603 PIWIL1 -0.68 -10.47 -0.5 2.22e-22 Menopause (age at onset); LUSC cis rs4803468 1.000 rs878083 chr19:41897688 G/A cg09537434 chr19:41945824 ATP5SL -0.88 -15.64 -0.65 9.54e-42 Height; LUSC cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg04450456 chr4:17643702 FAM184B 0.34 5.65 0.3 3.4e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7681440 0.874 rs1442151 chr4:90775491 T/A cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.23e-8 Dementia with Lewy bodies; LUSC cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg16584290 chr5:462447 EXOC3 0.48 8.77 0.43 9.28e-17 Cystic fibrosis severity; LUSC cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg05347473 chr6:146136440 FBXO30 0.51 9.03 0.44 1.37e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9646944 0.519 rs1041973 chr2:102955468 A/C cg20060108 chr2:102954350 IL1RL1 -0.38 -5.82 -0.3 1.4e-8 Blood protein levels; LUSC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg15649852 chr7:65879115 NA -0.41 -5.78 -0.3 1.74e-8 Aortic root size; LUSC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg06112835 chr11:68658793 MRPL21 0.51 7.8 0.39 8.21e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs701145 0.585 rs1713846 chr3:153787632 C/T cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs2012796 1.000 rs7153469 chr14:81820979 T/G cg02996355 chr14:81879375 NA 0.49 7.1 0.36 7.5e-12 Night sleep phenotypes; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg16606324 chr3:10149918 C3orf24 0.65 9.17 0.45 4.87e-18 Alzheimer's disease; LUSC cis rs2502731 0.539 rs3003615 chr9:130997892 C/T cg13642260 chr9:130955380 CIZ1 0.47 7.57 0.38 3.73e-13 Attention deficit hyperactivity disorder; LUSC trans rs11098499 0.754 rs11724409 chr4:120252361 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs17433780 0.836 rs61798917 chr1:89506093 G/A cg09516651 chr1:89888402 LOC400759 0.58 11.11 0.52 1.33e-24 Carotid intima media thickness; LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.61 0.65 1.21e-41 Platelet count; LUSC cis rs4588572 0.601 rs10942855 chr5:77737529 G/A cg11547950 chr5:77652471 NA -0.54 -7.86 -0.39 5.5e-14 Triglycerides; LUSC trans rs7819412 0.811 rs2409691 chr8:10943276 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.09 -0.36 7.85e-12 Triglycerides; LUSC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg03929089 chr4:120376271 NA -0.96 -16.75 -0.68 3.68e-46 Height; LUSC cis rs9303401 0.527 rs34835800 chr17:56764990 G/A cg25039879 chr17:56429692 SUPT4H1 0.64 8.11 0.41 9.88e-15 Cognitive test performance; LUSC cis rs1385374 0.858 rs12298615 chr12:129286756 G/A cg09035930 chr12:129282057 SLC15A4 -0.63 -6.85 -0.35 3.63e-11 Systemic lupus erythematosus; LUSC cis rs34779708 0.931 rs34375045 chr10:35362356 A/C cg04310649 chr10:35416472 CREM -0.4 -6.14 -0.32 2.34e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.41 -6.22 -0.32 1.52e-9 Prudent dietary pattern; LUSC trans rs35110281 0.776 rs2838338 chr21:45075582 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.36 0.53 1.62e-25 Mean corpuscular volume; LUSC cis rs262150 0.714 rs2657397 chr7:158785095 C/T cg19418458 chr7:158789849 NA -0.56 -8.89 -0.44 3.98e-17 Facial morphology (factor 20); LUSC trans rs3198697 0.663 rs12928099 chr16:15150505 C/A cg04146151 chr16:2155961 PKD1 -0.42 -5.99 -0.31 5.51e-9 Triglycerides; LUSC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg12927641 chr6:109611667 NA -0.37 -6.21 -0.32 1.55e-9 Reticulocyte fraction of red cells; LUSC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg16624210 chr5:671434 TPPP 0.47 5.92 0.31 8.21e-9 Lung disease severity in cystic fibrosis; LUSC trans rs7824557 0.767 rs7837036 chr8:11175489 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.43 0.42 1.06e-15 Retinal vascular caliber; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg05848811 chr11:47270335 ACP2;NR1H3 0.44 6.01 0.31 4.88e-9 Mosquito bite size; LUSC cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg16346588 chr10:242978 ZMYND11 -0.46 -6.2 -0.32 1.66e-9 Psychosis in Alzheimer's disease; LUSC cis rs16854884 0.526 rs7643341 chr3:143726980 C/T cg01302019 chr3:143689584 C3orf58 -0.37 -6.56 -0.34 2.07e-10 Economic and political preferences (feminism/equality); LUSC trans rs1819054 0.806 rs1528351 chr7:121167875 C/T cg12484325 chr11:3688985 CHRNA10 -0.43 -6.07 -0.32 3.38e-9 Hand grip strength; LUSC cis rs6484504 0.600 rs10835763 chr11:31345574 G/A cg26647111 chr11:31128758 NA 0.4 5.74 0.3 2.17e-8 Red blood cell count; LUSC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.44 -7.46 -0.38 7.51e-13 Total body bone mineral density; LUSC cis rs9378688 0.654 rs2505663 chr6:2325931 A/G cg12303981 chr6:2244766 GMDS -0.41 -5.79 -0.3 1.63e-8 Caudate nucleus volume; LUSC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.71 -9.22 -0.45 3.55e-18 Gut microbiome composition (summer); LUSC cis rs3820928 0.904 rs10188570 chr2:227792540 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.56 -0.38 4.04e-13 Pulmonary function; LUSC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.81 -0.3 1.49e-8 Intelligence (multi-trait analysis); LUSC cis rs7100689 0.646 rs7899791 chr10:82091950 A/T cg01528321 chr10:82214614 TSPAN14 0.82 12.46 0.56 1.53e-29 Post bronchodilator FEV1; LUSC cis rs1113500 0.933 rs1414674 chr1:108625947 A/G cg06207961 chr1:108661230 NA 0.41 7.57 0.38 3.58e-13 Growth-regulated protein alpha levels; LUSC trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21659725 chr3:3221576 CRBN -0.57 -8.26 -0.41 3.41e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -8.91 -0.44 3.3e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs1538970 0.816 rs868351 chr1:46009818 G/T cg06784218 chr1:46089804 CCDC17 0.35 6.18 0.32 1.84e-9 Platelet count; LUSC cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg11244672 chr19:19639970 YJEFN3 -0.58 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg03233332 chr7:66118400 NA 0.4 5.93 0.31 7.49e-9 Aortic root size; LUSC cis rs7845219 0.544 rs9643350 chr8:95917276 C/A cg16049864 chr8:95962084 TP53INP1 -0.42 -7.0 -0.36 1.37e-11 Type 2 diabetes; LUSC cis rs4722166 0.568 rs1880241 chr7:22759469 A/G cg26061582 chr7:22766209 IL6 0.38 5.96 0.31 6.34e-9 Lung cancer; LUSC cis rs7220711 1.000 rs59303349 chr17:41793668 A/G cg26893861 chr17:41843967 DUSP3 0.42 5.88 0.31 9.83e-9 Bone mineral density (spine);Bone mineral density (hip); LUSC trans rs11098499 0.954 rs12499324 chr4:120393786 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.28 0.32 1.08e-9 Corneal astigmatism; LUSC cis rs9527 0.614 rs11191589 chr10:104930382 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.41 -0.33 4.97e-10 Arsenic metabolism; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg24133106 chr7:129690864 ZC3HC1 0.36 5.95 0.31 6.63e-9 Tuberculosis; LUSC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs6547741 1.000 rs76784350 chr2:27764278 A/G cg27432699 chr2:27873401 GPN1 0.79 14.77 0.63 2.31e-38 Oral cavity cancer; LUSC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.81 0.39 7.22e-14 Bipolar disorder; LUSC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg00129232 chr17:37814104 STARD3 -0.5 -7.4 -0.38 1.09e-12 Asthma; LUSC cis rs7216064 1.000 rs55896768 chr17:65913358 T/C cg12091567 chr17:66097778 LOC651250 -0.72 -9.62 -0.47 1.68e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2075371 0.501 rs1646652 chr7:134024515 A/T cg00033643 chr7:134001901 SLC35B4 0.37 5.76 0.3 1.89e-8 Mean platelet volume; LUSC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -11.86 -0.54 2.59e-27 Extrinsic epigenetic age acceleration; LUSC cis rs12618769 0.652 rs3754877 chr2:99184019 A/G cg10123293 chr2:99228465 UNC50 0.45 7.19 0.37 4.34e-12 Bipolar disorder; LUSC cis rs909002 0.849 rs10914458 chr1:32096746 T/C cg01639898 chr1:32083012 HCRTR1 0.27 6.19 0.32 1.78e-9 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.0 -0.31 5.25e-9 Platelet count; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg08472276 chr7:1133186 C7orf50;GPER 0.39 6.53 0.34 2.49e-10 Longevity;Endometriosis; LUSC cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg23711669 chr6:146136114 FBXO30 0.87 16.35 0.67 1.52e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs1801251 0.896 rs2197563 chr2:233687080 G/A cg08000102 chr2:233561755 GIGYF2 -0.67 -11.05 -0.52 2.13e-24 Coronary artery disease; LUSC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg03806693 chr22:41940476 POLR3H -1.05 -14.81 -0.63 1.65e-38 Vitiligo; LUSC cis rs9650315 0.733 rs58705840 chr8:57206157 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs17253792 0.822 rs76164147 chr14:56140369 T/C cg01858014 chr14:56050164 KTN1 -0.79 -6.72 -0.35 7.8e-11 Putamen volume; LUSC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.83 -0.47 3.5e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs11105298 0.891 rs11105309 chr12:89909850 T/C cg00757033 chr12:89920650 WDR51B 0.59 10.34 0.49 6.32e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg12463550 chr7:65579703 CRCP 0.45 6.62 0.34 1.44e-10 Aortic root size; LUSC cis rs939574 0.790 rs114196239 chr2:220094307 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 6.07 0.32 3.4e-9 Platelet distribution width; LUSC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg24531977 chr5:56204891 C5orf35 -0.58 -8.58 -0.43 3.5e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg02353165 chr6:42928485 GNMT 0.73 12.84 0.57 6.05e-31 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg16103275 chr6:290800 DUSP22 0.42 6.96 0.36 1.84e-11 Menopause (age at onset); LUSC cis rs7827545 1.000 rs4909911 chr8:135565255 G/A cg17885191 chr8:135476712 NA 0.56 8.32 0.41 2.34e-15 Hypertension (SNP x SNP interaction); LUSC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg08859206 chr1:53392774 SCP2 0.56 9.34 0.46 1.38e-18 Monocyte count; LUSC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg06850241 chr22:41845214 NA 0.34 6.22 0.32 1.46e-9 Vitiligo; LUSC trans rs3960554 0.808 rs60481386 chr7:75700962 A/G cg19862616 chr7:65841803 NCRNA00174 0.83 9.74 0.47 6.94e-20 Eotaxin levels; LUSC cis rs7605827 0.930 rs2049720 chr2:15514982 T/C cg19274914 chr2:15703543 NA 0.47 9.07 0.44 1.03e-17 Educational attainment (years of education); LUSC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg19812747 chr11:111475976 SIK2 -0.57 -8.28 -0.41 2.94e-15 Primary sclerosing cholangitis; LUSC cis rs136211 0.619 rs9607337 chr22:36758849 A/T cg10790723 chr22:36903033 FOXRED2 0.39 5.79 0.3 1.6e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs113835537 0.529 rs11227502 chr11:66274148 T/G cg24851651 chr11:66362959 CCS 0.54 8.22 0.41 4.61e-15 Airway imaging phenotypes; LUSC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg12516959 chr21:47718080 NA -0.47 -7.37 -0.37 1.34e-12 Testicular germ cell tumor; LUSC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg12463550 chr7:65579703 CRCP 0.52 7.54 0.38 4.45e-13 Aortic root size; LUSC cis rs4702 0.591 rs7183988 chr15:91428589 T/G cg05469396 chr15:91419421 FURIN 0.46 8.18 0.41 6.19e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.21 0.37 3.85e-12 Platelet count; LUSC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg03433033 chr1:76189801 ACADM 0.8 13.3 0.59 1.14e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11756438 0.572 rs2638545 chr6:119000203 G/C cg18833306 chr6:118973337 C6orf204 0.36 5.73 0.3 2.2e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs78663649 0.540 rs7252709 chr19:16721183 T/G cg05286348 chr19:16641544 CHERP -1.37 -11.54 -0.53 3.65e-26 White blood cell count; LUSC cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg16797656 chr11:68205561 LRP5 0.35 5.94 0.31 7.28e-9 Total body bone mineral density; LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg07677032 chr17:61819896 STRADA -0.48 -8.19 -0.41 5.68e-15 Prudent dietary pattern; LUSC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg20307385 chr11:47447363 PSMC3 -0.47 -6.12 -0.32 2.57e-9 Subjective well-being; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03133917 chr7:155436674 RBM33 -0.48 -6.65 -0.34 1.17e-10 Hepatitis; LUSC cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg00701064 chr4:6280414 WFS1 0.55 12.87 0.58 4.65e-31 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs17014483 1.000 rs3017914 chr4:89654165 T/C cg01026744 chr4:89619053 NAP1L5;HERC3 0.67 5.69 0.3 2.77e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16920991 chr12:100536345 UHRF1BP1L 0.42 6.15 0.32 2.25e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5769707 0.681 rs739240 chr22:50052607 C/A cg07959070 chr22:50026188 C22orf34 -0.31 -5.7 -0.3 2.68e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9473147 0.516 rs7754971 chr6:47590476 C/T cg12968598 chr6:47444699 CD2AP 0.53 8.1 0.41 1.06e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs524023 0.914 rs555456 chr11:64418259 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.46 -0.5 2.42e-22 Urate levels in obese individuals; LUSC cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.16 -0.41 6.96e-15 Bone mineral density; LUSC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg08645402 chr16:4508243 NA 0.47 7.37 0.37 1.35e-12 Schizophrenia; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07444005 chr13:21678461 NA -0.4 -6.1 -0.32 2.95e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs17001868 0.568 rs17001846 chr22:40744053 A/G cg07138101 chr22:40742427 ADSL 0.63 7.43 0.38 9.05e-13 Mammographic density (dense area); LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg14004847 chr7:1930337 MAD1L1 -0.53 -8.13 -0.41 8.34e-15 Bipolar disorder and schizophrenia; LUSC cis rs6543140 0.964 rs10196334 chr2:103090041 T/C cg09003973 chr2:102972529 NA 0.54 6.83 0.35 4.07e-11 Blood protein levels; LUSC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.52 0.38 5.18e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg19747945 chr6:42946146 PEX6 -0.35 -5.78 -0.3 1.73e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.74 0.84 1.09e-88 Chronic sinus infection; LUSC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg03678062 chr6:149772716 ZC3H12D 0.3 6.03 0.31 4.46e-9 Dupuytren's disease; LUSC cis rs2860975 0.905 rs10882516 chr10:96791217 A/C cg09036531 chr10:96991505 NA -0.45 -6.31 -0.33 8.62e-10 Immune response to smallpox vaccine (IL-6); LUSC cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg16230307 chr14:35515116 FAM177A1 0.79 10.05 0.48 6.13e-21 Psoriasis; LUSC cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs4889855 0.556 rs11651818 chr17:78530300 A/G cg16591659 chr17:78472290 NA 0.31 5.8 0.3 1.55e-8 Fractional excretion of uric acid; LUSC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.4 0.46 8.81e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1376303 0.558 rs41479949 chr7:32946363 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.66 -5.88 -0.31 1.02e-8 Intelligence (multi-trait analysis); LUSC cis rs4919694 1.000 rs12258551 chr10:104767892 C/G cg04362960 chr10:104952993 NT5C2 1.17 13.71 0.6 3.13e-34 Arsenic metabolism; LUSC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg12311346 chr5:56204834 C5orf35 0.6 9.31 0.45 1.81e-18 Coronary artery disease; LUSC cis rs4722404 0.800 rs6943609 chr7:3141596 G/A cg19214707 chr7:3157722 NA 0.35 6.5 0.33 3e-10 Atopic dermatitis; LUSC cis rs1577917 0.917 rs12665464 chr6:86574133 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.71 -0.34 8.15e-11 Response to antipsychotic treatment; LUSC cis rs4969178 0.965 rs8071884 chr17:76398058 C/G cg20026190 chr17:76395443 PGS1 0.44 7.64 0.39 2.25e-13 HDL cholesterol levels; LUSC cis rs10781543 0.839 rs10870071 chr9:139382184 T/C cg14169450 chr9:139327907 INPP5E 0.44 7.81 0.39 7.37e-14 Monocyte percentage of white cells; LUSC cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg24642439 chr20:33292090 TP53INP2 0.5 7.58 0.38 3.34e-13 Height; LUSC cis rs1042058 0.565 rs2480297 chr10:30754512 A/G cg18806716 chr10:30721971 MAP3K8 -0.61 -9.9 -0.48 1.98e-20 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7777754 0.512 rs4470989 chr7:50562698 T/A cg18232548 chr7:50535776 DDC -0.67 -10.42 -0.5 3.2800000000000002e-22 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs9300255 0.602 rs1790126 chr12:123683563 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.89 -0.31 9.5e-9 Neutrophil percentage of white cells; LUSC cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg08085267 chr17:45401833 C17orf57 -0.48 -6.75 -0.35 6.7e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18404041 chr3:52824283 ITIH1 -0.62 -12.0 -0.55 7.62e-28 Bipolar disorder; LUSC cis rs5769707 0.592 rs6009783 chr22:50011001 C/G cg05373962 chr22:49881684 NA -0.41 -8.59 -0.43 3.46e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg15848620 chr12:58087721 OS9 -0.46 -6.68 -0.34 9.93e-11 Rheumatoid arthritis; LUSC cis rs68170813 0.559 rs2395880 chr7:107074264 A/G cg02696742 chr7:106810147 HBP1 -0.62 -8.92 -0.44 3.19e-17 Coronary artery disease; LUSC cis rs79387448 0.626 rs80256362 chr2:103025501 A/G cg09003973 chr2:102972529 NA 0.97 10.06 0.48 5.93e-21 Gut microbiota (bacterial taxa); LUSC cis rs11785400 1.000 rs10108059 chr8:143750028 G/T cg24634471 chr8:143751801 JRK -0.58 -8.79 -0.43 8.11e-17 Schizophrenia; LUSC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg04369109 chr6:150039330 LATS1 -0.54 -8.08 -0.4 1.22e-14 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25675393 chr21:46494274 ADARB1;C21orf122 -0.49 -6.06 -0.31 3.64e-9 Bipolar disorder and schizophrenia; LUSC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.6 8.96 0.44 2.25e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs806215 0.826 rs712699 chr7:127250597 G/A cg25922125 chr7:127225783 GCC1 0.56 6.98 0.36 1.62e-11 Type 2 diabetes; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg25382848 chr3:107809996 CD47 0.47 6.07 0.32 3.44e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4332037 0.510 rs58673065 chr7:1885600 A/G cg12432903 chr7:1882776 MAD1L1 0.44 6.06 0.31 3.71e-9 Bipolar disorder; LUSC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg20243544 chr17:37824526 PNMT 0.39 5.92 0.31 7.97e-9 Self-reported allergy; LUSC trans rs12579753 0.917 rs7132465 chr12:82205840 C/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs4555082 0.874 rs11622166 chr14:105759763 C/A cg06808227 chr14:105710500 BRF1 -0.63 -9.13 -0.45 6.81e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs3789045 0.560 rs4553256 chr1:204411144 C/T cg17419461 chr1:204415978 PIK3C2B -0.51 -5.89 -0.31 9.64e-9 Educational attainment (college completion); LUSC cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg08807101 chr21:30365312 RNF160 -0.72 -12.75 -0.57 1.27e-30 Dental caries; LUSC cis rs2629540 0.847 rs11245342 chr10:126414084 C/T cg08799069 chr10:126477246 METTL10 0.63 8.54 0.42 4.78e-16 Cocaine dependence; LUSC cis rs2835872 0.965 rs1787330 chr21:39002787 G/A cg20424643 chr21:39039972 KCNJ6 -0.4 -6.12 -0.32 2.59e-9 Electroencephalographic traits in alcoholism; LUSC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg02896835 chr1:92012615 NA -0.66 -11.99 -0.55 8.63e-28 Breast cancer; LUSC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg22968622 chr17:43663579 NA 0.79 12.19 0.55 1.61e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs4868731 0.656 rs6884233 chr5:163532624 C/T cg10167512 chr13:112838934 NA 0.33 6.16 0.32 2.14e-9 Common carotid intima-media thickness; LUSC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg26597838 chr10:835615 NA 0.8 9.93 0.48 1.6e-20 Eosinophil percentage of granulocytes; LUSC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg14440974 chr22:39074834 NA -0.37 -6.0 -0.31 5.03e-9 Menopause (age at onset); LUSC cis rs1729951 0.575 rs10935214 chr3:136693485 G/A cg12473912 chr3:136751656 NA 0.39 6.83 0.35 3.96e-11 Neuroticism; LUSC cis rs10740039 0.810 rs1372709 chr10:62381424 A/G cg18175470 chr10:62150864 ANK3 -0.45 -6.6 -0.34 1.58e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.07 0.36 9.14e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9326248 0.581 rs11216242 chr11:116901549 G/A cg20608306 chr11:116969690 SIK3 0.37 6.97 0.36 1.73e-11 Blood protein levels; LUSC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg08270630 chr22:50330655 NA -0.45 -6.77 -0.35 5.64e-11 Schizophrenia; LUSC cis rs7202877 0.706 rs247438 chr16:75432649 C/G cg04384234 chr16:75411784 CFDP1 0.67 9.87 0.48 2.49e-20 Type 2 diabetes;Type 1 diabetes; LUSC cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg18225595 chr11:63971243 STIP1 0.43 6.95 0.36 1.98e-11 Platelet count; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg24503407 chr1:205819492 PM20D1 0.94 17.99 0.7 4.59e-51 Menarche (age at onset); LUSC cis rs66887589 0.616 rs6843509 chr4:120220196 G/A cg24375607 chr4:120327624 NA 0.5 7.48 0.38 6.46e-13 Diastolic blood pressure; LUSC cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.83 -0.35 4.12e-11 Monocyte percentage of white cells; LUSC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg18876405 chr7:65276391 NA 0.75 13.55 0.6 1.23e-33 Aortic root size; LUSC cis rs3862030 0.839 rs2281880 chr10:104269217 G/A cg05855489 chr10:104503620 C10orf26 0.5 7.61 0.38 2.88e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg09365446 chr1:150670422 GOLPH3L 0.47 6.7 0.34 8.79e-11 Melanoma; LUSC cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.63 0.85 1.69e-95 Chronic sinus infection; LUSC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg13939156 chr17:80058883 NA -0.34 -6.86 -0.35 3.32e-11 Life satisfaction; LUSC cis rs4604732 0.631 rs60311891 chr1:247623127 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.42 6.25 0.32 1.23e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.42 0.33 4.76e-10 Lung cancer; LUSC cis rs11264799 0.520 rs849816 chr1:157542074 A/C cg18268488 chr1:157545234 FCRL4 0.38 7.53 0.38 4.67e-13 IgA nephropathy; LUSC cis rs7746199 0.736 rs34965299 chr6:27521856 A/G cg26958806 chr6:27640298 NA 0.77 6.55 0.34 2.23e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.88 0.63 8.61e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6700896 0.500 rs66470832 chr1:66130631 T/A cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs1351696 1 rs1351696 chr11:48382471 A/G cg15704280 chr7:45808275 SEPT13 -0.68 -6.43 -0.33 4.36e-10 D-dimer levels; LUSC cis rs9527 0.830 rs11191442 chr10:104643596 T/A cg05855489 chr10:104503620 C10orf26 0.47 6.48 0.33 3.34e-10 Arsenic metabolism; LUSC cis rs2197308 0.765 rs12230545 chr12:37927114 C/T cg13010199 chr12:38710504 ALG10B -0.63 -9.78 -0.47 5.08e-20 Morning vs. evening chronotype; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg27094323 chr7:1216898 NA -0.43 -7.36 -0.37 1.48e-12 Longevity;Endometriosis; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg06873352 chr17:61820015 STRADA 0.71 12.76 0.57 1.21e-30 Prudent dietary pattern; LUSC cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.53 6.72 0.35 7.91e-11 Diabetic retinopathy; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg10445487 chr16:75599896 GABARAPL2 0.36 6.06 0.31 3.72e-9 Tuberculosis; LUSC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg22875332 chr1:76189707 ACADM 0.76 10.24 0.49 1.44e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs250677 0.687 rs250671 chr5:148446523 T/C cg23229984 chr5:148520753 ABLIM3 0.41 6.48 0.33 3.22e-10 Breast cancer; LUSC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs796364 0.806 rs10931889 chr2:201101900 G/T cg23649088 chr2:200775458 C2orf69 -0.57 -6.72 -0.35 7.73e-11 Schizophrenia; LUSC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg18225595 chr11:63971243 STIP1 0.43 6.99 0.36 1.47e-11 Platelet count; LUSC cis rs459571 0.920 rs2520094 chr9:136919985 A/T cg13789015 chr9:136890014 NCRNA00094 0.71 13.3 0.59 1.1e-32 Platelet distribution width; LUSC cis rs6669072 0.565 rs12743498 chr1:91267791 C/A cg08895590 chr1:91227319 NA -0.27 -5.75 -0.3 1.99e-8 Cognitive function; LUSC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg09826364 chr7:158789723 NA -0.38 -6.03 -0.31 4.24e-9 Facial morphology (factor 20); LUSC cis rs7100689 0.646 rs2994390 chr10:82074395 C/A cg00277334 chr10:82204260 NA -0.57 -8.53 -0.42 5.19e-16 Post bronchodilator FEV1; LUSC cis rs62400317 0.859 rs12191566 chr6:45160002 T/C cg18551225 chr6:44695536 NA -0.44 -7.2 -0.37 4.1e-12 Total body bone mineral density; LUSC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.11 0.32 2.79e-9 Schizophrenia; LUSC cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg07520158 chr7:32535189 LSM5;AVL9 -0.51 -7.26 -0.37 2.65e-12 Cognitive ability; LUSC cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg24692254 chr21:30365293 RNF160 0.91 18.67 0.71 8.51e-54 Dental caries; LUSC cis rs709400 0.628 rs72708854 chr14:103864885 T/C cg10523860 chr14:103875565 MARK3 -0.4 -6.3 -0.33 9.36e-10 Body mass index; LUSC trans rs4295623 0.559 rs2409836 chr8:11689228 T/G cg15556689 chr8:8085844 FLJ10661 0.56 8.21 0.41 4.73e-15 Morning vs. evening chronotype; LUSC trans rs9951602 0.512 rs7234283 chr18:76640552 T/G cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg23283495 chr1:209979779 IRF6 0.7 9.08 0.44 9.71e-18 Cleft lip with or without cleft palate; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg04234412 chr22:24373322 LOC391322 0.77 9.78 0.47 4.82e-20 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs727505 1.000 rs10271646 chr7:124549573 T/C cg23710748 chr7:124431027 NA -0.4 -7.19 -0.37 4.36e-12 Lewy body disease; LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.05 0.64 1.96e-39 Platelet count; LUSC cis rs7827545 1.000 rs4909481 chr8:135564555 A/G cg17885191 chr8:135476712 NA 0.56 8.32 0.41 2.34e-15 Hypertension (SNP x SNP interaction); LUSC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs11792861 0.589 rs2176692 chr9:111927723 G/A cg13535736 chr9:111863775 C9orf5 -0.41 -6.58 -0.34 1.84e-10 Menarche (age at onset); LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.5 6.3 0.33 9.35e-10 Renal function-related traits (BUN); LUSC cis rs963731 0.649 rs10186762 chr2:39219361 A/G cg04010122 chr2:39346883 SOS1 -0.79 -5.73 -0.3 2.2e-8 Corticobasal degeneration; LUSC cis rs73416724 1.000 rs80193186 chr6:43362324 G/T cg26312998 chr6:43337775 ZNF318 0.55 6.51 0.34 2.7e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs1832871 0.711 rs56043101 chr6:158682277 A/G cg07165851 chr6:158734300 TULP4 0.51 7.8 0.39 7.72e-14 Height; LUSC trans rs35110281 0.591 rs230642 chr21:44915533 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.58 -10.04 -0.48 6.77e-21 Mean corpuscular volume; LUSC cis rs1577917 0.917 rs1579886 chr6:86557191 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs950027 0.620 rs1153855 chr15:45660758 C/G cg14582100 chr15:45693742 SPATA5L1 0.46 8.62 0.43 2.7e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs3862030 0.668 rs12781718 chr10:104227433 G/A cg05855489 chr10:104503620 C10orf26 0.49 7.4 0.38 1.1e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs500891 0.525 rs13215578 chr6:84107234 C/T cg08257003 chr6:84140564 ME1 0.34 8.29 0.41 2.85e-15 Platelet-derived growth factor BB levels; LUSC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg15369054 chr17:80825471 TBCD 0.7 11.61 0.54 2.08e-26 Breast cancer; LUSC cis rs61931739 0.534 rs1608912 chr12:34008574 C/T cg06521331 chr12:34319734 NA -0.47 -8.33 -0.41 2.11e-15 Morning vs. evening chronotype; LUSC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.47 10.13 0.48 3.42e-21 Autism spectrum disorder or schizophrenia; LUSC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg15335139 chr3:50242325 SLC38A3 -0.25 -5.64 -0.3 3.57e-8 Body mass index; LUSC cis rs7582180 0.568 rs10186134 chr2:100939501 T/A cg12002119 chr2:101014098 CHST10 0.35 5.8 0.3 1.5e-8 Intelligence (multi-trait analysis); LUSC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg12516959 chr21:47718080 NA 0.49 7.86 0.39 5.45e-14 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs477692 0.569 rs10764882 chr10:131306496 C/G cg25636556 chr4:3505128 NA 0.31 5.98 0.31 5.63e-9 Response to temozolomide; LUSC cis rs9303401 0.659 rs7223708 chr17:56896398 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.71 0.6 3.09e-34 Cognitive test performance; LUSC trans rs61931739 0.749 rs7315233 chr12:34271975 G/T cg26384229 chr12:38710491 ALG10B 0.54 8.61 0.43 3e-16 Morning vs. evening chronotype; LUSC cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.27 -0.32 1.11e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9469578 1.000 rs16869464 chr6:33715127 A/G cg18708504 chr6:33715942 IP6K3 0.72 8.8 0.43 7.52e-17 Phosphorus levels; LUSC cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.44 -0.46 6.6e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs405956 1.000 rs1338020 chr6:105577686 C/T cg22580625 chr6:105627791 POPDC3 -0.59 -5.77 -0.3 1.84e-8 QT interval; LUSC cis rs7131987 0.903 rs2194520 chr12:29423712 C/T cg09582351 chr12:29534625 ERGIC2 -0.31 -6.74 -0.35 6.79e-11 QT interval; LUSC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg10556349 chr10:835070 NA -0.58 -6.42 -0.33 4.74e-10 Eosinophil percentage of granulocytes; LUSC trans rs208520 0.507 rs3903670 chr6:66812183 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.22 -25.88 -0.82 8.37e-82 Exhaled nitric oxide output; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03359731 chr4:48833388 OCIAD1 0.47 6.96 0.36 1.84e-11 Triglycerides; LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg23711669 chr6:146136114 FBXO30 0.76 13.43 0.59 3.68e-33 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06797661 chr2:48338981 NA 0.41 6.13 0.32 2.42e-9 Triglycerides; LUSC cis rs6901250 1.000 rs993394 chr6:117117143 G/A cg12892004 chr6:117198278 RFX6 0.44 7.92 0.4 3.52e-14 C-reactive protein levels; LUSC cis rs2573652 1.000 rs2581345 chr15:100514291 A/G cg09918751 chr15:100517450 ADAMTS17 -0.43 -8.03 -0.4 1.68e-14 Height; LUSC cis rs727505 0.909 rs7810427 chr7:124645103 C/T cg23710748 chr7:124431027 NA -0.37 -6.46 -0.33 3.71e-10 Lewy body disease; LUSC cis rs10864907 0.614 rs12711745 chr2:113700355 T/C cg06156847 chr2:113672199 IL1F7 -0.28 -5.83 -0.3 1.32e-8 Pulmonary function; LUSC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg19678392 chr7:94953810 PON1 -0.38 -6.09 -0.32 3.07e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg12863693 chr15:85201151 NMB 0.34 6.23 0.32 1.37e-9 Schizophrenia; LUSC cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg01483505 chr11:975446 AP2A2 0.4 5.81 0.3 1.44e-8 Alzheimer's disease (late onset); LUSC trans rs28588043 0.593 rs61816052 chr1:170953309 A/G cg07135042 chr19:56905152 ZNF582 -0.62 -6.3 -0.33 9.37e-10 Number of children (6+ vs. 0 or 1); LUSC trans rs71537559 1 rs71537559 chr6:27309779 G/C cg06606381 chr12:133084897 FBRSL1 -0.99 -8.92 -0.44 3.13e-17 Squamous cell lung carcinoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10433104 chr11:18417767 LDHA -0.42 -6.26 -0.32 1.18e-9 Electrocardiographic conduction measures; LUSC cis rs7106204 0.764 rs7949823 chr11:24213668 C/G ch.11.24196551F chr11:24239977 NA 0.91 7.76 0.39 1.02e-13 Response to Homoharringtonine (cytotoxicity); LUSC trans rs60843830 1.000 rs56321614 chr2:268191 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.22 0.49 1.68e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg01879757 chr17:41196368 BRCA1 -0.45 -6.99 -0.36 1.54e-11 Menopause (age at onset); LUSC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg09491104 chr22:46646882 C22orf40 -0.58 -6.23 -0.32 1.39e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6456156 0.766 rs150112 chr6:167509878 C/T cg07741184 chr6:167504864 NA -0.35 -6.19 -0.32 1.76e-9 Primary biliary cholangitis; LUSC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg07701084 chr6:150067640 NUP43 0.52 7.78 0.39 9.16e-14 Lung cancer; LUSC cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 13.37 0.59 5.93e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2076222 1.000 rs2076349 chr1:209800230 C/T cg00257659 chr1:209800214 LAMB3 -1.01 -8.3 -0.41 2.68e-15 Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08356097 chr3:75484209 FAM86D -0.47 -6.62 -0.34 1.47e-10 Electrocardiographic conduction measures; LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.7 0.47 9.13e-20 Personality dimensions; LUSC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg06808227 chr14:105710500 BRF1 -0.7 -11.0 -0.52 3.29e-24 Mean platelet volume;Platelet distribution width; LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg25767906 chr1:53392781 SCP2 -0.61 -11.73 -0.54 7.42e-27 Monocyte count; LUSC cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg23625390 chr15:77176239 SCAPER 0.39 5.65 0.3 3.36e-8 Blood metabolite levels; LUSC cis rs4253772 0.872 rs45576140 chr22:46638216 C/G cg24881330 chr22:46731750 TRMU 0.63 5.85 0.31 1.15e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg14582100 chr15:45693742 SPATA5L1 0.59 10.42 0.5 3.2800000000000002e-22 Homoarginine levels; LUSC cis rs6693567 0.545 rs4446975 chr1:150456169 C/T cg15654264 chr1:150340011 RPRD2 0.41 6.73 0.35 7.51e-11 Migraine; LUSC cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.88e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg17173187 chr15:85201210 NMB 0.37 6.56 0.34 2.08e-10 Schizophrenia; LUSC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.44 -6.42 -0.33 4.74e-10 Schizophrenia; LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg18404041 chr3:52824283 ITIH1 0.58 10.99 0.52 3.56e-24 Bipolar disorder; LUSC cis rs12579753 0.917 rs10862361 chr12:82197946 T/C cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs7917772 0.582 rs4917975 chr10:104358407 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.94 0.51 5.25e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6456156 0.565 rs12529959 chr6:167469292 T/C cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC trans rs17767294 0.708 rs72848754 chr6:27878458 T/A cg19566879 chr6:16334128 ATXN1 0.66 5.98 0.31 5.71e-9 Parkinson's disease; LUSC cis rs79149102 0.579 rs12594117 chr15:75323648 C/G cg17294928 chr15:75287854 SCAMP5 -0.71 -6.4 -0.33 5.27e-10 Lung cancer; LUSC cis rs11583043 1.000 rs6700743 chr1:101447384 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.87 0.31 1.03e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg01689657 chr7:91764605 CYP51A1 0.32 5.65 0.3 3.4e-8 Breast cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15715881 chr1:145209236 NOTCH2NL -0.42 -6.19 -0.32 1.73e-9 Electrocardiographic conduction measures; LUSC cis rs2652834 0.507 rs7175973 chr15:63425027 T/A cg05507819 chr15:63340323 TPM1 0.47 6.03 0.31 4.35e-9 HDL cholesterol; LUSC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg05585544 chr11:47624801 NA -0.41 -7.01 -0.36 1.29e-11 Subjective well-being; LUSC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.63 -0.47 1.55e-19 Prostate cancer; LUSC trans rs637571 0.544 rs55704213 chr11:65730002 C/A cg17712092 chr4:129076599 LARP1B 0.81 12.19 0.55 1.59e-28 Eosinophil percentage of white cells; LUSC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg26380479 chr7:97908229 NA -0.26 -5.93 -0.31 7.48e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.93 0.48 1.53e-20 Bipolar disorder; LUSC cis rs10504229 0.516 rs11781671 chr8:57992733 T/C cg11062466 chr8:58055876 NA 0.39 5.79 0.3 1.58e-8 Developmental language disorder (linguistic errors); LUSC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg08508325 chr11:3079039 CARS -0.53 -13.47 -0.59 2.53e-33 Longevity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23888281 chr1:45476762 HECTD3;UROD -0.46 -6.01 -0.31 4.88e-9 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg24562669 chr7:97807699 LMTK2 0.35 6.04 0.31 4.21e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg09324608 chr17:30823087 MYO1D 0.35 5.75 0.3 1.97e-8 Schizophrenia; LUSC cis rs1865760 0.516 rs9393683 chr6:26066198 A/G cg17691542 chr6:26056736 HIST1H1C 0.53 8.09 0.4 1.1e-14 Height; LUSC cis rs6430585 0.583 rs3087343 chr2:136622543 T/G cg07169764 chr2:136633963 MCM6 1.23 19.55 0.73 2.84e-57 Corneal structure; LUSC cis rs10489525 0.599 rs34710929 chr1:115606608 G/A cg01522456 chr1:115632236 TSPAN2 0.51 7.58 0.38 3.51e-13 Autism; LUSC cis rs7605827 0.930 rs6753645 chr2:15539556 G/C cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs2625529 0.617 rs16956369 chr15:72182813 C/T cg16672083 chr15:72433130 SENP8 0.5 8.14 0.41 7.88e-15 Red blood cell count; LUSC cis rs10072221 0.836 rs6453217 chr5:75708442 C/T cg03132911 chr5:75698732 IQGAP2 0.36 6.06 0.31 3.74e-9 Mean platelet volume; LUSC cis rs4947962 0.617 rs10488140 chr7:55138388 A/G cg23757825 chr7:55092271 EGFR 0.49 6.64 0.34 1.28e-10 Subjective response to lithium treatment; LUSC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs17255340 0.539 rs1144195 chr6:83978225 A/C cg08257003 chr6:84140564 ME1 0.33 8.21 0.41 5.02e-15 Platelet-derived growth factor BB levels; LUSC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg20917491 chr3:195578259 NA -0.42 -7.07 -0.36 8.88e-12 Bronchopulmonary dysplasia; LUSC cis rs790123 0.666 rs790124 chr3:122388605 A/G cg00926285 chr3:122398533 PARP14 -0.39 -5.66 -0.3 3.3e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs734999 0.588 rs4648562 chr1:2535613 C/A cg18932078 chr1:2524107 MMEL1 0.32 7.04 0.36 1.13e-11 Ulcerative colitis; LUSC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg13393036 chr8:95962371 TP53INP1 -0.33 -6.27 -0.32 1.14e-9 Type 2 diabetes; LUSC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg13390004 chr1:15929781 NA 0.42 7.03 0.36 1.18e-11 Systolic blood pressure; LUSC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7119167 0.802 rs11235743 chr11:73124826 A/G cg17517138 chr11:73019481 ARHGEF17 0.52 5.93 0.31 7.51e-9 Blood protein levels; LUSC cis rs4319547 0.656 rs1553179 chr12:122831073 A/G cg23029597 chr12:123009494 RSRC2 -0.75 -9.41 -0.46 8.04e-19 Body mass index; LUSC cis rs11785400 0.762 rs7460801 chr8:143730972 C/A cg10596483 chr8:143751796 JRK 0.53 7.59 0.38 3.17e-13 Schizophrenia; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg16479474 chr6:28041457 NA 0.34 5.93 0.31 7.45e-9 Parkinson's disease; LUSC cis rs7772486 0.875 rs9403765 chr6:146368041 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.05 0.36 1.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2880765 0.835 rs7161880 chr15:86018746 C/T cg13263323 chr15:86062960 AKAP13 -0.35 -5.64 -0.3 3.57e-8 Coronary artery disease; LUSC cis rs1371867 0.846 rs1660345 chr8:101322762 C/A cg06002616 chr8:101225028 SPAG1 -0.47 -7.61 -0.38 2.86e-13 Atrioventricular conduction; LUSC cis rs911555 0.755 rs12435516 chr14:103954404 T/C cg12935359 chr14:103987150 CKB 0.66 10.79 0.51 1.68e-23 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.98 -0.31 5.72e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg03264133 chr6:25882463 NA -0.48 -8.95 -0.44 2.51e-17 Blood metabolite levels; LUSC cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14442939 chr10:27389572 ANKRD26 0.84 9.84 0.47 3.2e-20 Breast cancer; LUSC cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg11266682 chr4:10021025 SLC2A9 0.53 10.0 0.48 9.15e-21 Bone mineral density; LUSC cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 8.75 0.43 1.1e-16 Schizophrenia; LUSC cis rs6942756 0.713 rs691158 chr7:129129982 G/T cg02491457 chr7:128862824 NA -0.41 -5.77 -0.3 1.77e-8 White matter hyperintensity burden; LUSC cis rs1018836 0.923 rs7837230 chr8:91574281 C/T cg16814680 chr8:91681699 NA -0.75 -12.48 -0.56 1.3e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs5758659 0.652 rs133314 chr22:42401841 G/A cg04733989 chr22:42467013 NAGA 0.39 6.55 0.34 2.2e-10 Cognitive function; LUSC cis rs61931739 0.817 rs10743842 chr12:34306859 C/T cg06521331 chr12:34319734 NA -0.39 -6.87 -0.35 3.18e-11 Morning vs. evening chronotype; LUSC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC cis rs5758511 0.689 rs45441993 chr22:42471738 C/A cg00645731 chr22:42541494 CYP2D7P1 0.54 7.76 0.39 1.07e-13 Birth weight; LUSC cis rs79839061 0.520 rs11730111 chr4:942833 C/T cg14530993 chr4:882597 GAK 0.67 6.78 0.35 5.48e-11 Intelligence (multi-trait analysis); LUSC cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg02175503 chr12:58329896 NA 0.48 6.91 0.35 2.43e-11 Intelligence (multi-trait analysis); LUSC cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg26924012 chr15:45694286 SPATA5L1 1.01 15.63 0.65 9.91e-42 Homoarginine levels; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg13453750 chr1:205783389 SLC41A1 -0.31 -6.12 -0.32 2.56e-9 Menarche (age at onset); LUSC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg17971929 chr21:40555470 PSMG1 -0.69 -11.53 -0.53 4.06e-26 Cognitive function; LUSC cis rs6500602 0.610 rs1659499 chr16:4595269 G/A cg08645402 chr16:4508243 NA -0.42 -6.98 -0.36 1.6e-11 Schizophrenia; LUSC cis rs782590 0.967 rs11125579 chr2:55739804 T/C cg03859395 chr2:55845619 SMEK2 0.79 14.18 0.61 4.51e-36 Metabolic syndrome; LUSC cis rs4930561 0.765 rs34493482 chr11:67969508 T/C cg16338278 chr11:67432957 ALDH3B2 0.4 6.73 0.35 7.48e-11 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg03433033 chr1:76189801 ACADM 0.82 14.87 0.63 9.95e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs79349575 0.749 rs2270574 chr17:47022270 C/T cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg06363034 chr20:62225388 GMEB2 -0.46 -7.7 -0.39 1.53e-13 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.83 0.44 5.81e-17 Prudent dietary pattern; LUSC cis rs9650657 0.537 rs4841457 chr8:10773511 T/G cg21775007 chr8:11205619 TDH -0.49 -6.93 -0.35 2.21e-11 Neuroticism; LUSC cis rs10792830 0.706 rs563773 chr11:85673270 C/T cg07180834 chr11:85838833 NA -0.3 -5.73 -0.3 2.19e-8 Psychosis and Alzheimer's disease; LUSC trans rs2204008 0.658 rs12371956 chr12:38298010 A/T cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Bladder cancer; LUSC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg24531977 chr5:56204891 C5orf35 0.89 14.35 0.62 1.08e-36 Initial pursuit acceleration; LUSC cis rs3784262 1.000 rs7178497 chr15:58240333 C/T cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.99 -0.31 5.54e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs11190604 1.000 rs10883500 chr10:102238324 T/G cg07080220 chr10:102295463 HIF1AN 0.64 8.46 0.42 8.25e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7927592 0.913 rs6591344 chr11:68360873 G/A cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.58e-9 Total body bone mineral density; LUSC cis rs9473147 0.543 rs9367279 chr6:47448336 A/G cg12968598 chr6:47444699 CD2AP 0.53 8.18 0.41 6.12e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs4631830 0.720 rs11004415 chr10:51498181 G/A cg10326726 chr10:51549505 MSMB 0.34 5.88 0.31 9.99e-9 Prostate-specific antigen levels; LUSC cis rs7223966 1.000 rs11079509 chr17:61762148 G/T cg05941027 chr17:61774174 LIMD2 0.22 5.76 0.3 1.95e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs939574 0.790 rs72955439 chr2:220090804 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 6.07 0.32 3.4e-9 Platelet distribution width; LUSC cis rs936229 0.813 rs4886629 chr15:75072558 G/C cg14664628 chr15:75095509 CSK -1.0 -16.86 -0.68 1.45e-46 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.93 9.03 0.44 1.36e-17 Lung cancer in ever smokers; LUSC trans rs10486158 0.843 rs7797517 chr7:7389587 A/C cg01895333 chr3:109035405 DPPA2 -0.38 -6.03 -0.31 4.33e-9 Bipolar disorder and schizophrenia; LUSC cis rs921968 0.643 rs832802 chr2:219386899 C/T cg02176678 chr2:219576539 TTLL4 0.63 11.63 0.54 1.76e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs3755132 0.852 rs6711424 chr2:15745333 T/G cg12888861 chr2:15731646 DDX1 0.5 7.27 0.37 2.55e-12 Wilms tumor; LUSC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg01065977 chr19:18549689 ISYNA1 -0.23 -5.74 -0.3 2.14e-8 Breast cancer; LUSC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg00990874 chr7:1149470 C7orf50 -0.46 -6.16 -0.32 2.06e-9 Bronchopulmonary dysplasia; LUSC cis rs9660992 0.674 rs72745221 chr1:205262337 G/A cg21643547 chr1:205240462 TMCC2 -0.49 -9.3 -0.45 1.88e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9399135 0.967 rs9389261 chr6:135371148 C/G cg22676075 chr6:135203613 NA 0.47 7.27 0.37 2.62e-12 Red blood cell count; LUSC cis rs6088590 0.965 rs6119534 chr20:33441257 C/T cg08999081 chr20:33150536 PIGU 0.45 8.01 0.4 1.92e-14 Coronary artery disease; LUSC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg09491104 chr22:46646882 C22orf40 -0.64 -7.39 -0.37 1.22e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs12701220 0.572 rs7792825 chr7:1006573 T/C cg19665696 chr7:949154 ADAP1 0.47 6.23 0.32 1.38e-9 Bronchopulmonary dysplasia; LUSC trans rs9944715 1.000 rs6507693 chr18:43829137 G/A cg01718231 chr17:29326311 RNF135 -0.52 -7.3 -0.37 2.12e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg06494592 chr3:125709126 NA -0.51 -5.79 -0.3 1.6e-8 Blood pressure (smoking interaction); LUSC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg07424592 chr7:64974309 NA 0.7 6.05 0.31 3.99e-9 Diabetic kidney disease; LUSC cis rs11997175 0.631 rs7826866 chr8:33665090 A/T ch.8.33884649F chr8:33765107 NA 0.4 6.16 0.32 2.13e-9 Body mass index; LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.34 0.37 1.59e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9329221 0.623 rs7825778 chr8:10261010 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.17 -0.37 4.95e-12 Neuroticism; LUSC cis rs9611519 0.964 rs5995992 chr22:41487218 T/C cg03806693 chr22:41940476 POLR3H -0.56 -7.62 -0.38 2.69e-13 Neuroticism; LUSC cis rs10743315 0.643 rs75398828 chr12:19340053 T/C cg02471346 chr12:19282374 PLEKHA5 0.59 5.81 0.3 1.46e-8 Gut microbiota (bacterial taxa); LUSC trans rs2739330 0.828 rs5760098 chr22:24248314 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.57 -8.72 -0.43 1.31e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1865760 0.566 rs2858993 chr6:26087856 T/A cg16482183 chr6:26056742 HIST1H1C 0.56 8.22 0.41 4.57e-15 Height; LUSC cis rs4356932 0.729 rs6855257 chr4:76964788 T/C cg00809888 chr4:76862425 NAAA 0.34 5.68 0.3 2.94e-8 Blood protein levels; LUSC cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg23029597 chr12:123009494 RSRC2 -0.73 -9.05 -0.44 1.24e-17 Body mass index; LUSC cis rs7617480 0.648 rs4858800 chr3:48755820 A/G cg21141812 chr3:48556323 PFKFB4 0.33 6.05 0.31 3.98e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs4285028 0.796 rs12638492 chr3:121711763 G/A cg11130432 chr3:121712080 ILDR1 -0.66 -10.09 -0.48 4.69e-21 Multiple sclerosis; LUSC cis rs72781680 0.950 rs72796402 chr2:24180104 A/G cg08917208 chr2:24149416 ATAD2B 1.02 10.65 0.5 5.21e-23 Lymphocyte counts; LUSC cis rs9987353 0.566 rs34389718 chr8:9065525 A/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.53 -0.34 2.42e-10 Recombination measurement; LUSC trans rs11700980 0.551 rs2832018 chr21:30111639 T/C cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg17178900 chr1:205818956 PM20D1 -0.8 -13.44 -0.59 3.28e-33 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02307953 chr2:99797349 MRPL30;MITD1 -0.42 -6.37 -0.33 6.16e-10 Electrocardiographic conduction measures; LUSC cis rs55665837 1.000 rs10047429 chr11:14439032 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs11997175 0.846 rs34860600 chr8:33761566 C/A ch.8.33884649F chr8:33765107 NA 0.58 9.35 0.46 1.32e-18 Body mass index; LUSC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg03240473 chr21:43526662 UMODL1;C21orf128 -0.58 -9.48 -0.46 5.03e-19 IgG glycosylation; LUSC cis rs6460942 0.915 rs6965564 chr7:12306013 C/T cg06484146 chr7:12443880 VWDE -0.51 -6.24 -0.32 1.32e-9 Coronary artery disease; LUSC trans rs7824557 0.564 rs1435275 chr8:11235735 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.01e-14 Retinal vascular caliber; LUSC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg11663144 chr21:46675770 NA -0.36 -5.92 -0.31 7.91e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.23e-8 Total body bone mineral density; LUSC cis rs11674184 0.743 rs12470971 chr2:11725241 A/G cg07314298 chr2:11723111 GREB1 0.79 15.09 0.64 1.41e-39 Endometriosis; LUSC cis rs10740039 0.586 rs7068462 chr10:62395998 A/C cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs911555 0.504 rs745079 chr14:104073551 G/A cg24130564 chr14:104152367 KLC1 -0.7 -11.34 -0.53 1.9e-25 Intelligence (multi-trait analysis); LUSC cis rs977987 0.815 rs11149818 chr16:75419373 G/A cg04384234 chr16:75411784 CFDP1 -0.46 -7.58 -0.38 3.49e-13 Dupuytren's disease; LUSC cis rs6700896 0.500 rs11208707 chr1:66139513 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.51 6.03 0.31 4.34e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg06740227 chr12:86229804 RASSF9 0.45 7.2 0.37 4.14e-12 Major depressive disorder; LUSC cis rs2742417 0.603 rs2673075 chr3:45778288 C/A cg04837898 chr3:45731254 SACM1L -0.46 -7.43 -0.38 9.02e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg08219700 chr8:58056026 NA 0.63 7.54 0.38 4.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2637266 0.967 rs7900230 chr10:78366879 A/G cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.8 -0.35 4.74e-11 Monocyte percentage of white cells; LUSC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg11645453 chr3:52864694 ITIH4 0.36 7.0 0.36 1.44e-11 Bipolar disorder; LUSC cis rs9815354 0.812 rs73075234 chr3:42051801 G/A cg03022575 chr3:42003672 ULK4 0.61 6.52 0.34 2.61e-10 Pulse pressure;Diastolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19816011 chr2:113012631 ZC3H8 -0.41 -6.02 -0.31 4.57e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg14019146 chr3:50243930 SLC38A3 -0.37 -8.21 -0.41 5.02e-15 Body mass index; LUSC cis rs10197940 0.624 rs4461258 chr2:152429679 A/G cg06191203 chr2:152266755 RIF1 0.53 7.06 0.36 9.87e-12 Lung cancer; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg08088566 chr11:430123 ANO9 0.63 7.05 0.36 1.01e-11 Body mass index; LUSC cis rs7666738 0.515 rs13434650 chr4:98889886 A/G cg17366294 chr4:99064904 C4orf37 0.51 8.29 0.41 2.78e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg22800045 chr5:56110881 MAP3K1 0.76 9.84 0.47 3.24e-20 Initial pursuit acceleration; LUSC cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 10.57 0.5 1.01e-22 Chronic sinus infection; LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.43 0.53 8.95e-26 Prudent dietary pattern; LUSC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg13628971 chr7:2884303 GNA12 0.5 6.93 0.35 2.23e-11 Height; LUSC cis rs757278 0.552 rs4730793 chr7:117311117 C/T cg10524701 chr7:117356490 CTTNBP2 0.4 5.75 0.3 1.99e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg21926612 chr6:163149169 PACRG;PARK2 -0.58 -8.56 -0.42 4.07e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg23172400 chr8:95962367 TP53INP1 -0.41 -8.5 -0.42 6.51e-16 Type 2 diabetes; LUSC cis rs11098499 0.698 rs4422403 chr4:120258194 C/T cg09307838 chr4:120376055 NA 0.63 9.55 0.46 2.8e-19 Corneal astigmatism; LUSC cis rs977987 0.778 rs4888426 chr16:75476451 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.16 -0.36 5.2e-12 Dupuytren's disease; LUSC cis rs9921338 0.924 rs72773831 chr16:11412927 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.75 -0.35 6.64e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1348850 0.793 rs6734528 chr2:178493731 G/A cg22681709 chr2:178499509 PDE11A -0.56 -10.64 -0.5 5.72e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6845621 0.745 rs1517995 chr4:18863110 A/G cg12196642 chr4:18937545 NA -0.32 -5.88 -0.31 9.96e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.46 0.38 7.32e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.754 rs12506487 chr4:120271361 T/G cg25214090 chr10:38739885 LOC399744 0.39 5.96 0.31 6.43e-9 Corneal astigmatism; LUSC cis rs3764021 0.870 rs10772085 chr12:9876877 C/G cg20894963 chr12:9885564 CLECL1 0.34 7.06 0.36 9.92e-12 Type 1 diabetes; LUSC trans rs12458462 0.665 rs2035085 chr18:77485280 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.48 -6.55 -0.34 2.15e-10 Monocyte count; LUSC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg04398451 chr17:18023971 MYO15A 0.41 6.43 0.33 4.36e-10 Total body bone mineral density; LUSC trans rs34421088 0.548 rs2618443 chr8:11384556 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.39 -0.46 9.99e-19 Neuroticism; LUSC cis rs7577696 0.962 rs4952250 chr2:32343699 T/G cg02381751 chr2:32503542 YIPF4 -0.4 -5.71 -0.3 2.47e-8 Inflammatory biomarkers; LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg03576123 chr11:487126 PTDSS2 -0.95 -10.55 -0.5 1.22e-22 Body mass index; LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9733 0.650 rs3738485 chr1:150552392 C/G cg04414720 chr1:150670196 GOLPH3L -0.41 -6.27 -0.32 1.14e-9 Tonsillectomy; LUSC trans rs61931739 0.635 rs1405024 chr12:33937939 A/T cg13010199 chr12:38710504 ALG10B -0.41 -6.15 -0.32 2.23e-9 Morning vs. evening chronotype; LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13089785 0.965 rs1920221 chr3:123606952 A/G cg02012769 chr3:123398346 MYLK 0.34 6.38 0.33 6.06e-10 Intelligence (multi-trait analysis); LUSC cis rs3806933 0.522 rs13179305 chr5:110444474 G/A cg04022379 chr5:110408740 TSLP 0.64 9.3 0.45 1.83e-18 Eosinophilic esophagitis; LUSC cis rs6977660 0.714 rs6943204 chr7:19818671 A/G cg07541023 chr7:19748670 TWISTNB 0.6 6.53 0.34 2.48e-10 Thyroid stimulating hormone; LUSC cis rs700651 0.821 rs4850812 chr2:198743655 G/T cg00792783 chr2:198669748 PLCL1 -0.45 -5.99 -0.31 5.43e-9 Intracranial aneurysm; LUSC cis rs3931020 0.688 rs277374 chr1:75200486 G/A cg21906852 chr1:75198582 TYW3;CRYZ -0.45 -5.86 -0.31 1.09e-8 Resistin levels; LUSC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg00825309 chr19:58991885 ZNF446 -0.49 -7.03 -0.36 1.17e-11 Uric acid clearance; LUSC cis rs2369473 1 rs2369473 chr1:160210727 C/A cg02974968 chr1:160236444 NA -0.38 -6.82 -0.35 4.2e-11 Squamous cell lung carcinoma; LUSC cis rs12476592 0.602 rs10469944 chr2:63816672 C/G cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs9611565 0.694 rs9611591 chr22:41830212 G/A cg03806693 chr22:41940476 POLR3H 0.84 12.18 0.55 1.75e-28 Vitiligo; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22801400 chr10:93170010 LOC100188947;HECTD2 -0.45 -6.58 -0.34 1.77e-10 Electrocardiographic conduction measures; LUSC trans rs7937682 0.924 rs7924683 chr11:111555796 C/A cg18187862 chr3:45730750 SACM1L 0.57 7.3 0.37 2.18e-12 Primary sclerosing cholangitis; LUSC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg14668632 chr7:2872130 GNA12 -0.52 -7.4 -0.38 1.14e-12 Height; LUSC cis rs240764 0.658 rs10872628 chr6:101176349 A/G cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.12e-9 Neuroticism; LUSC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg08270630 chr22:50330655 NA -0.42 -6.29 -0.33 1e-9 Schizophrenia; LUSC cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg05985134 chr18:33552581 C18orf21 0.51 7.05 0.36 1.01e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -7.44 -0.38 8.56e-13 Chronic sinus infection; LUSC cis rs7296418 0.699 rs11057219 chr12:123750073 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.47 -0.33 3.53e-10 Platelet count; LUSC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg00857998 chr1:205179979 DSTYK -0.63 -9.59 -0.46 2.21e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg22535103 chr8:58192502 C8orf71 -0.56 -6.71 -0.34 8.29e-11 Developmental language disorder (linguistic errors); LUSC cis rs644148 0.730 rs2571044 chr19:44985573 G/A cg15540054 chr19:45004280 ZNF180 -0.51 -6.97 -0.36 1.73e-11 Personality dimensions; LUSC cis rs7681440 0.967 rs1372517 chr4:90755909 G/A cg01966878 chr4:90757139 SNCA -0.34 -5.86 -0.31 1.11e-8 Dementia with Lewy bodies; LUSC cis rs9467160 0.559 rs2753911 chr6:24442288 C/T cg20631270 chr6:24437470 GPLD1 0.39 6.16 0.32 2.13e-9 Liver enzyme levels; LUSC cis rs965513 1.000 rs7030280 chr9:100535267 C/T cg13688889 chr9:100608707 NA -0.55 -8.33 -0.41 2.07e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg03732007 chr1:2071316 PRKCZ -0.51 -8.88 -0.44 4.17e-17 Height; LUSC cis rs11098499 0.570 rs6832740 chr4:120546136 T/C cg09307838 chr4:120376055 NA 0.63 9.5 0.46 4.35e-19 Corneal astigmatism; LUSC cis rs3820928 0.874 rs55959848 chr2:227805426 C/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.14e-13 Pulmonary function; LUSC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg13647721 chr17:30228624 UTP6 0.58 6.31 0.33 8.95e-10 Hip circumference adjusted for BMI; LUSC cis rs7927592 0.871 rs113020558 chr11:68296832 G/A cg16797656 chr11:68205561 LRP5 0.38 6.28 0.32 1.07e-9 Total body bone mineral density; LUSC cis rs483180 0.532 rs561931 chr1:120254506 A/G cg19096424 chr1:120255104 PHGDH 0.52 7.4 0.38 1.12e-12 Macular telangiectasia type 2; LUSC cis rs9790314 0.586 rs11710086 chr3:161125858 A/T cg03342759 chr3:160939853 NMD3 -0.44 -6.8 -0.35 4.85e-11 Morning vs. evening chronotype; LUSC cis rs11105298 0.891 rs10858864 chr12:89846230 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.3 -0.37 2.06e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs13011075 0.919 rs34196827 chr2:68621427 G/A cg14221825 chr19:46271408 SIX5 0.43 6.19 0.32 1.73e-9 Mean corpuscular volume; LUSC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg06808227 chr14:105710500 BRF1 -0.67 -10.31 -0.49 8.31e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC trans rs9929218 0.954 rs12919719 chr16:68822341 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.78 -0.54 5.16e-27 Colorectal cancer; LUSC cis rs10791323 0.559 rs10750548 chr11:133729469 A/G cg15485101 chr11:133734466 NA 0.4 7.43 0.38 8.9e-13 Childhood ear infection; LUSC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg08847533 chr14:75593920 NEK9 0.83 14.61 0.62 9.66e-38 Height; LUSC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.46 7.16 0.36 5.13e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8060686 0.516 rs11075670 chr16:68288393 C/G cg05110241 chr16:68378359 PRMT7 -0.53 -6.55 -0.34 2.14e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13732083 chr21:47605072 C21orf56 -0.42 -6.1 -0.32 3.01e-9 Testicular germ cell tumor; LUSC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg07636037 chr3:49044803 WDR6 0.74 9.68 0.47 1.07e-19 Menarche (age at onset); LUSC cis rs9467773 0.967 rs9467775 chr6:26513435 G/A cg09904177 chr6:26538194 HMGN4 0.75 14.22 0.61 3.36e-36 Intelligence (multi-trait analysis); LUSC cis rs12476592 0.516 rs196124 chr2:63854138 A/G cg10828910 chr2:63850056 LOC388955 0.49 5.76 0.3 1.89e-8 Childhood ear infection; LUSC cis rs1371867 0.875 rs1660319 chr8:101337530 A/G cg06002616 chr8:101225028 SPAG1 -0.4 -6.7 -0.34 8.89e-11 Atrioventricular conduction; LUSC cis rs11030122 0.673 rs10835601 chr11:4106416 G/A cg18678763 chr11:4115507 RRM1 -0.5 -6.59 -0.34 1.69e-10 Mean platelet volume;Platelet distribution width; LUSC cis rs1983891 0.955 rs6917270 chr6:41548755 A/G cg15051332 chr6:41514432 FOXP4 0.39 5.65 0.3 3.5e-8 Prostate cancer; LUSC cis rs1348850 0.567 rs1405714 chr2:178538584 A/G cg22681709 chr2:178499509 PDE11A 0.57 11.77 0.54 5.33e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg18306943 chr3:40428807 ENTPD3 0.39 5.93 0.31 7.72e-9 Renal cell carcinoma; LUSC cis rs6121246 0.954 rs6089093 chr20:30421459 C/T cg13852791 chr20:30311386 BCL2L1 0.83 10.4 0.49 3.92e-22 Mean corpuscular hemoglobin; LUSC cis rs6714788 0.503 rs1370356 chr2:100675241 G/C cg07810366 chr2:100720526 AFF3 -0.38 -6.03 -0.31 4.41e-9 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.41e-9 Crohn's disease; LUSC cis rs7937682 1.000 rs11213980 chr11:111562692 A/T cg19812747 chr11:111475976 SIK2 0.47 6.62 0.34 1.48e-10 Primary sclerosing cholangitis; LUSC cis rs12681287 0.640 rs7460650 chr8:87474085 A/G cg27223183 chr8:87520930 FAM82B -0.56 -7.73 -0.39 1.24e-13 Caudate activity during reward; LUSC trans rs2832077 0.943 rs2832106 chr21:30191767 A/G cg14791747 chr16:20752902 THUMPD1 0.73 9.55 0.46 2.84e-19 Cognitive test performance; LUSC cis rs11690935 0.959 rs10207085 chr2:172585885 T/G cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.65 -0.63 6.79e-38 Schizophrenia; LUSC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg19592336 chr6:28129416 ZNF389 0.48 6.3 0.33 9.46e-10 Depression; LUSC cis rs1185460 0.967 rs4545564 chr11:118937518 T/C cg23280166 chr11:118938394 VPS11 0.48 7.62 0.39 2.57e-13 Coronary artery disease; LUSC cis rs68170813 0.523 rs12154285 chr7:106993573 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.56 -0.46 2.74e-19 Coronary artery disease; LUSC cis rs950027 0.584 rs1145086 chr15:45654327 A/G cg26924012 chr15:45694286 SPATA5L1 0.79 12.5 0.56 1.13e-29 Response to fenofibrate (adiponectin levels); LUSC trans rs1486139 1.000 rs9639945 chr7:46268593 T/C cg17534202 chr9:96721102 NA -0.34 -6.09 -0.32 3.18e-9 Select biomarker traits; LUSC cis rs7267979 1.000 rs6083856 chr20:25407585 C/T cg03522245 chr20:25566470 NINL -0.35 -5.72 -0.3 2.36e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs7824557 0.767 rs28507159 chr8:11166076 C/T cg06636001 chr8:8085503 FLJ10661 0.52 7.85 0.39 5.82e-14 Retinal vascular caliber; LUSC cis rs1113500 0.933 rs10494089 chr1:108626695 T/G cg11967332 chr1:108735228 SLC25A24 0.38 5.76 0.3 1.92e-8 Growth-regulated protein alpha levels; LUSC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs11112613 0.713 rs11112592 chr12:105951702 C/T cg03607813 chr12:105948248 NA -0.78 -12.1 -0.55 3.48e-28 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg23711669 chr6:146136114 FBXO30 0.93 18.15 0.7 1e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs9653442 0.564 rs4850924 chr2:100782273 A/G cg22139774 chr2:100720529 AFF3 -0.41 -7.03 -0.36 1.17e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9653442 0.564 rs4851256 chr2:100775045 A/G cg22139774 chr2:100720529 AFF3 -0.39 -6.69 -0.34 9.69e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg09365446 chr1:150670422 GOLPH3L 0.46 6.9 0.35 2.59e-11 Melanoma; LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg18190219 chr22:46762943 CELSR1 -0.55 -6.0 -0.31 5.1e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.9 0.77 1.58e-66 Prudent dietary pattern; LUSC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg22875332 chr1:76189707 ACADM 0.84 13.91 0.61 5.19e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg19346786 chr7:2764209 NA -0.47 -7.95 -0.4 2.99e-14 Height; LUSC cis rs6664467 1 rs6664467 chr1:151738403 G/A cg07092448 chr1:151763213 TDRKH -1.23 -12.17 -0.55 1.89e-28 Carotid plaque burden; LUSC cis rs3862030 0.839 rs7078679 chr10:104284017 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -9.75 -0.47 6.19e-20 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6121246 0.909 rs3203770 chr20:30382315 A/G cg18721089 chr20:30220636 NA -0.35 -5.92 -0.31 8.06e-9 Mean corpuscular hemoglobin; LUSC cis rs2797160 0.522 rs6925158 chr6:125940188 T/G cg05901451 chr6:126070800 HEY2 -0.43 -6.05 -0.31 3.96e-9 Endometrial cancer; LUSC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg23887609 chr12:130822674 PIWIL1 0.49 7.33 0.37 1.78e-12 Menopause (age at onset); LUSC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg04414720 chr1:150670196 GOLPH3L 0.5 7.8 0.39 8.1e-14 Melanoma; LUSC cis rs3087591 0.639 rs2342053 chr17:29722196 A/G cg24425628 chr17:29625626 OMG;NF1 0.47 7.05 0.36 1.06e-11 Hip circumference; LUSC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.73 0.3 2.25e-8 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg01475377 chr6:109611718 NA 0.46 8.45 0.42 9.08e-16 Reticulocyte fraction of red cells; LUSC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg22166914 chr1:53195759 ZYG11B -0.67 -11.74 -0.54 7.29e-27 Monocyte count; LUSC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg09021430 chr5:549028 NA -0.54 -7.07 -0.36 8.97e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6060717 0.610 rs6058393 chr20:34608664 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.4 -0.33 5.25e-10 Hip circumference adjusted for BMI; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg26706201 chr11:57103334 SSRP1 -0.43 -7.4 -0.38 1.1e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9303401 0.703 rs9911583 chr17:57210721 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.44 -6.63 -0.34 1.35e-10 Cognitive test performance; LUSC cis rs447735 0.587 rs11647958 chr16:89720909 A/T cg04240660 chr16:89714849 CHMP1A -0.38 -6.01 -0.31 4.92e-9 Hemoglobin concentration; LUSC cis rs5758511 0.680 rs5758688 chr22:42662501 T/C cg00645731 chr22:42541494 CYP2D7P1 0.58 10.23 0.49 1.52e-21 Birth weight; LUSC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg13683864 chr3:40499215 RPL14 -0.94 -15.99 -0.66 3.83e-43 Renal cell carcinoma; LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg18404041 chr3:52824283 ITIH1 -0.56 -10.63 -0.5 6.41e-23 Bipolar disorder; LUSC cis rs3790515 1.000 rs12145375 chr1:151785229 T/C cg07092448 chr1:151763213 TDRKH -0.89 -6.92 -0.35 2.37e-11 Depressive symptoms (SSRI exposure interaction); LUSC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg05313129 chr8:58192883 C8orf71 -0.51 -6.98 -0.36 1.55e-11 Developmental language disorder (linguistic errors); LUSC cis rs55675132 0.620 rs2798470 chr1:115636403 A/T cg01522456 chr1:115632236 TSPAN2 0.47 6.49 0.33 3.02e-10 Schizophrenia; LUSC cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg07606381 chr6:8435919 SLC35B3 0.75 12.61 0.57 4.55e-30 Motion sickness; LUSC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs9925964 0.933 rs9923231 chr16:31107689 C/T cg02466173 chr16:30829666 NA 0.35 6.32 0.33 8.39e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg11764359 chr7:65958608 NA -0.51 -6.57 -0.34 1.94e-10 Aortic root size; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg07677032 chr17:61819896 STRADA 0.52 8.8 0.43 7.73e-17 Prudent dietary pattern; LUSC cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs2285947 0.935 rs10258022 chr7:21583667 A/G cg04471919 chr7:21584483 DNAH11 0.35 7.71 0.39 1.5e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg23630131 chr7:65973040 NA -0.22 -6.03 -0.31 4.35e-9 Aortic root size; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20033598 chr7:112579757 C7orf60 0.4 6.59 0.34 1.71e-10 Asthma; LUSC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg08847533 chr14:75593920 NEK9 0.84 15.38 0.64 9.75e-41 Height; LUSC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.62 7.93 0.4 3.31e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs73200209 0.744 rs2392968 chr12:116533861 A/C cg01776926 chr12:116560359 MED13L -0.49 -6.16 -0.32 2.14e-9 Total body bone mineral density; LUSC cis rs7223966 1.000 rs8081541 chr17:61812483 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.9 0.35 2.69e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9287719 0.967 rs6727768 chr2:10757479 T/C cg00105475 chr2:10696890 NA 0.36 6.01 0.31 4.93e-9 Prostate cancer; LUSC cis rs10744422 0.920 rs10773657 chr12:123327900 C/A cg25930673 chr12:123319894 HIP1R -0.62 -6.16 -0.32 2.04e-9 Schizophrenia; LUSC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg11845111 chr2:191398756 TMEM194B -0.54 -9.18 -0.45 4.54e-18 Pulse pressure; LUSC cis rs1961456 0.542 rs75501607 chr8:18244753 C/T cg18736775 chr8:18248649 NAT2 -0.55 -6.57 -0.34 1.88e-10 Total cholesterol levels; LUSC cis rs9614461 0.702 rs3788648 chr22:45727180 G/A cg13318129 chr22:45737514 FAM118A 0.77 8.93 0.44 2.94e-17 Tonsillectomy; LUSC cis rs12908161 1.000 rs35630683 chr15:85349231 T/C cg12863693 chr15:85201151 NMB 0.42 8.43 0.42 1.05e-15 Schizophrenia; LUSC cis rs1153858 1.000 rs1346266 chr15:45694516 G/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 5.05e-15 Homoarginine levels; LUSC cis rs7166081 0.672 rs12441715 chr15:67860587 G/A cg05925327 chr15:68127851 NA -0.4 -6.11 -0.32 2.7e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs6142102 0.923 rs6059586 chr20:32540501 G/A cg08999081 chr20:33150536 PIGU 0.33 5.75 0.3 2e-8 Skin pigmentation; LUSC cis rs3741151 0.773 rs79915238 chr11:73272947 C/T cg17517138 chr11:73019481 ARHGEF17 0.98 8.18 0.41 6.04e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4654899 1.000 rs6683542 chr1:21369610 T/C cg01072550 chr1:21505969 NA -0.56 -8.54 -0.42 4.74e-16 Superior frontal gyrus grey matter volume; LUSC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg26597838 chr10:835615 NA 0.89 12.01 0.55 7.2e-28 Eosinophil percentage of granulocytes; LUSC trans rs35110281 0.837 rs2838343 chr21:45078035 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.77 0.47 5.4e-20 Mean corpuscular volume; LUSC cis rs3087591 0.960 rs2953000 chr17:29509791 C/T cg24425628 chr17:29625626 OMG;NF1 0.55 8.08 0.4 1.22e-14 Hip circumference; LUSC cis rs951366 0.538 rs3761919 chr1:205694720 G/A cg11965913 chr1:205819406 PM20D1 -0.48 -6.68 -0.34 1.02e-10 Menarche (age at onset); LUSC cis rs7940866 0.834 rs10791108 chr11:130849354 T/A cg12179176 chr11:130786555 SNX19 0.58 8.77 0.43 9.33e-17 Schizophrenia; LUSC cis rs9341808 0.556 rs2223875 chr6:81045452 C/T cg08355045 chr6:80787529 NA 0.46 8.04 0.4 1.53e-14 Sitting height ratio; LUSC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -7.47 -0.38 7.05e-13 Cystic fibrosis severity; LUSC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg13395646 chr4:1353034 KIAA1530 -0.63 -9.84 -0.47 3.24e-20 Obesity-related traits; LUSC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs2348418 0.966 rs11049698 chr12:28688287 C/T cg13890972 chr12:28721907 NA -0.34 -5.79 -0.3 1.66e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs8060686 0.641 rs9923710 chr16:68224018 C/T cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11074549 chr14:75642944 TMED10 -0.47 -6.16 -0.32 2.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs7241530 0.662 rs924888 chr18:75900840 G/A cg14642773 chr18:75888474 NA 0.4 6.11 0.32 2.71e-9 Educational attainment (years of education); LUSC cis rs60695258 0.550 rs2007132 chr4:87972585 G/T cg10685359 chr4:87814065 C4orf36 -0.35 -6.24 -0.32 1.3e-9 Hematocrit; LUSC cis rs6982240 0.514 rs2060357 chr8:142259829 G/A cg00131261 chr8:142287264 NA -0.37 -6.12 -0.32 2.68e-9 Tonsillectomy; LUSC cis rs61935443 0.673 rs11107770 chr12:95275147 C/T cg21533806 chr12:95267307 NA -0.54 -6.85 -0.35 3.56e-11 Schizophrenia; LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg04944784 chr2:26401820 FAM59B -0.74 -10.67 -0.5 4.46e-23 Gut microbiome composition (summer); LUSC cis rs11971779 0.616 rs6965143 chr7:139026608 C/G cg07862535 chr7:139043722 LUC7L2 0.53 6.58 0.34 1.84e-10 Diisocyanate-induced asthma; LUSC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg13206674 chr6:150067644 NUP43 0.58 8.97 0.44 2.19e-17 Lung cancer; LUSC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.47 8.83 0.44 6.02e-17 Monocyte percentage of white cells; LUSC cis rs3862435 0.572 rs9796504 chr15:90927939 C/T cg22089800 chr15:90895588 ZNF774 0.55 6.21 0.32 1.59e-9 Response to exercise (triglyceride level interaction); LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg11843238 chr5:131593191 PDLIM4 0.51 9.06 0.44 1.14e-17 Acylcarnitine levels; LUSC trans rs17685 0.664 rs9801113 chr7:75792031 C/T cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg01483505 chr11:975446 AP2A2 0.43 6.06 0.31 3.77e-9 Alzheimer's disease (late onset); LUSC cis rs17125944 0.686 rs7144029 chr14:53333616 G/T cg00686598 chr14:53173677 PSMC6 -0.67 -6.13 -0.32 2.41e-9 Alzheimer's disease (late onset); LUSC cis rs7927771 0.524 rs7933184 chr11:47682402 C/T cg18512352 chr11:47633146 NA 0.27 5.7 0.3 2.65e-8 Subjective well-being; LUSC cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg06784218 chr1:46089804 CCDC17 0.49 9.83 0.47 3.31e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg18404041 chr3:52824283 ITIH1 -0.52 -9.84 -0.47 3.18e-20 Bipolar disorder; LUSC cis rs11676348 0.967 rs4672873 chr2:219005210 A/G cg00012203 chr2:219082015 ARPC2 -0.54 -8.51 -0.42 6.01e-16 Ulcerative colitis; LUSC cis rs55675132 0.704 rs12119227 chr1:115589615 G/A cg01522456 chr1:115632236 TSPAN2 -0.46 -5.72 -0.3 2.35e-8 Schizophrenia; LUSC cis rs6598955 0.617 rs11247883 chr1:26576247 T/G cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg23131131 chr22:24373011 LOC391322 -0.5 -7.13 -0.36 6.42e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7336332 0.598 rs10220056 chr13:28003781 T/G cg22138327 chr13:27999177 GTF3A 0.82 9.95 0.48 1.34e-20 Weight; LUSC cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg15103426 chr22:29168792 CCDC117 -0.44 -5.77 -0.3 1.78e-8 Lymphocyte counts; LUSC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.18 -0.41 6.02e-15 Neuroticism; LUSC trans rs71435601 0.628 rs312936 chr2:21408647 T/A cg20757404 chr19:378427 NA 0.38 5.99 0.31 5.36e-9 Cholesterol, total; LUSC trans rs7937682 0.632 rs11608193 chr11:111732215 T/C cg18187862 chr3:45730750 SACM1L -0.53 -6.43 -0.33 4.3e-10 Primary sclerosing cholangitis; LUSC cis rs12220238 1.000 rs7909664 chr10:75869754 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.65 7.85 0.39 5.54e-14 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs72781680 0.898 rs2339851 chr2:23938883 G/A cg08917208 chr2:24149416 ATAD2B 0.99 10.09 0.48 4.53e-21 Lymphocyte counts; LUSC cis rs9811920 0.683 rs813218 chr3:99592596 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.34 6.5 0.34 2.87e-10 Axial length; LUSC cis rs9928842 0.941 rs1808427 chr16:75241394 T/C cg09066997 chr16:75300724 BCAR1 0.53 6.4 0.33 5.15e-10 Alcoholic chronic pancreatitis; LUSC cis rs9653442 0.900 rs6754937 chr2:100827720 T/G cg22139774 chr2:100720529 AFF3 -0.46 -7.94 -0.4 3.12e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg11752832 chr7:134001865 SLC35B4 0.56 8.8 0.43 7.57e-17 Mean platelet volume; LUSC cis rs61931739 0.817 rs1705754 chr12:34145569 A/G cg06521331 chr12:34319734 NA -0.38 -6.49 -0.33 3.01e-10 Morning vs. evening chronotype; LUSC cis rs4964805 0.773 rs4964623 chr12:104222742 G/A cg02344784 chr12:104178138 NT5DC3 0.42 6.51 0.34 2.82e-10 Attention deficit hyperactivity disorder; LUSC cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg08213375 chr14:104286397 PPP1R13B -0.38 -6.97 -0.36 1.67e-11 Reticulocyte count; LUSC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.63 0.34 1.38e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs12760731 0.623 rs11584977 chr1:178387283 A/G cg00404053 chr1:178313656 RASAL2 0.48 5.76 0.3 1.91e-8 Obesity-related traits; LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg18681998 chr4:17616180 MED28 0.88 15.94 0.66 6.07e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.85 -0.35 3.57e-11 Monocyte percentage of white cells; LUSC cis rs317865 0.737 rs55949632 chr4:16207072 T/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.61 5.84 0.3 1.22e-8 Kidney disease (early stage) in type 1 diabetes; LUSC trans rs2018683 0.770 rs10951208 chr7:29022504 G/T cg19402173 chr7:128379420 CALU -0.59 -9.5 -0.46 4.24e-19 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs16949788 1.000 rs16949849 chr15:66682709 A/G cg08120210 chr15:66682733 MAP2K1 -0.59 -5.93 -0.31 7.77e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.41 0.46 8.23e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00828689 chr3:196697064 PIGZ -0.42 -6.12 -0.32 2.58e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs372883 0.648 rs368322 chr21:30717151 C/T cg08807101 chr21:30365312 RNF160 -0.66 -10.17 -0.49 2.34e-21 Pancreatic cancer; LUSC cis rs9311676 0.632 rs6777066 chr3:58361603 T/C cg26110898 chr3:58419937 PDHB 0.41 6.64 0.34 1.28e-10 Systemic lupus erythematosus; LUSC cis rs4132509 0.744 rs12047209 chr1:243954407 A/C cg21452805 chr1:244014465 NA 0.58 5.79 0.3 1.58e-8 RR interval (heart rate); LUSC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.36 -5.78 -0.3 1.75e-8 Total body bone mineral density; LUSC trans rs7939886 0.920 rs11227428 chr11:55941972 C/G cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC cis rs7428 0.924 rs908304 chr2:85573049 G/A cg24342717 chr2:85555507 TGOLN2 -0.62 -8.99 -0.44 1.93e-17 Ear protrusion; LUSC cis rs10769945 0.679 rs217213 chr11:1979118 C/G cg26856596 chr11:1961893 NA -0.34 -6.5 -0.34 2.91e-10 DNA methylation (variation); LUSC cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg05283184 chr6:79620031 NA -0.55 -11.32 -0.53 2.35e-25 Intelligence (multi-trait analysis); LUSC cis rs2932538 0.846 rs7546203 chr1:113154529 C/A cg22162597 chr1:113214053 CAPZA1 0.69 9.99 0.48 9.74e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs478304 0.651 rs948494 chr11:65552118 G/A cg27068330 chr11:65405492 SIPA1 -0.8 -11.33 -0.53 2.13e-25 Acne (severe); LUSC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg00310523 chr12:86230176 RASSF9 0.49 9.35 0.46 1.28e-18 Major depressive disorder; LUSC cis rs7578035 0.500 rs17021941 chr2:99384299 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -5.77 -0.3 1.84e-8 Bipolar disorder; LUSC cis rs939574 1.000 rs79013471 chr2:220096122 C/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.07 8.71 0.43 1.42e-16 Platelet distribution width; LUSC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg22105103 chr4:187893119 NA 0.73 14.28 0.62 1.86e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs317689 0.680 rs315140 chr12:69790780 A/T cg20891283 chr12:69753455 YEATS4 0.58 8.0 0.4 2.01e-14 Response to diuretic therapy; LUSC cis rs2297797 0.660 rs3820667 chr1:109968410 A/C cg08367326 chr1:110052010 AMIGO1 0.39 5.86 0.31 1.13e-8 Cognitive function; LUSC trans rs12677056 0.739 rs12677528 chr8:113308722 T/C cg12159992 chr12:102059490 MYBPC1 0.37 6.16 0.32 2.05e-9 Peripheral artery disease; LUSC cis rs9677476 0.863 rs7601741 chr2:232062351 C/T cg07929768 chr2:232055508 NA 0.35 6.51 0.34 2.81e-10 Food antigen IgG levels; LUSC cis rs3772130 0.545 rs7340674 chr3:121574215 T/C cg20356878 chr3:121714668 ILDR1 0.61 9.79 0.47 4.6e-20 Cognitive performance; LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg10802521 chr3:52805072 NEK4 -0.58 -9.1 -0.45 8.23e-18 Bipolar disorder; LUSC cis rs72720396 0.789 rs12022460 chr1:91202257 A/G cg13456504 chr1:91191583 NA -0.53 -7.8 -0.39 7.74e-14 Morning vs. evening chronotype;Chronotype; LUSC cis rs11871801 0.560 rs8068844 chr17:40571284 T/C cg16308533 chr17:40838983 CNTNAP1 0.37 5.75 0.3 2e-8 Crohn's disease; LUSC cis rs642803 0.613 rs489574 chr11:65542739 C/T cg02870584 chr11:65547924 DKFZp761E198 0.43 5.79 0.3 1.59e-8 Urate levels; LUSC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11644478 chr21:40555479 PSMG1 0.62 9.68 0.47 1.06e-19 Menarche (age at onset); LUSC cis rs1790761 0.607 rs656652 chr11:67343957 C/T cg14500267 chr11:67383377 NA 0.34 6.51 0.34 2.77e-10 Mean corpuscular volume; LUSC cis rs2692947 0.832 rs2438978 chr2:96679740 G/C cg23100626 chr2:96804247 ASTL 0.31 7.38 0.37 1.25e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9309473 0.687 rs7576824 chr2:73611281 C/T cg20560298 chr2:73613845 ALMS1 0.62 9.78 0.47 4.92e-20 Metabolite levels; LUSC cis rs977987 0.806 rs2865530 chr16:75414376 G/T cg04384234 chr16:75411784 CFDP1 -0.44 -7.34 -0.37 1.61e-12 Dupuytren's disease; LUSC cis rs614226 1.000 rs1167726 chr12:120967364 A/C cg01236616 chr12:121019343 POP5 -1.31 -21.85 -0.77 2.39e-66 Type 1 diabetes nephropathy; LUSC cis rs11677370 0.574 rs10209122 chr2:3871186 C/A cg17052675 chr2:3827356 NA -0.62 -9.47 -0.46 5.31e-19 Type 2 diabetes; LUSC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg01657329 chr11:68192670 LRP5 -0.43 -6.41 -0.33 4.96e-10 Total body bone mineral density; LUSC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg12311346 chr5:56204834 C5orf35 -0.64 -9.86 -0.47 2.73e-20 Coronary artery disease; LUSC cis rs8017423 0.935 rs17260827 chr14:90732703 G/A cg14092571 chr14:90743983 NA 0.36 5.77 0.3 1.85e-8 Mortality in heart failure; LUSC cis rs11690935 0.959 rs75922913 chr2:172620152 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.26 -0.62 2.3e-36 Schizophrenia; LUSC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg06634786 chr22:41940651 POLR3H -0.55 -6.46 -0.33 3.75e-10 Vitiligo; LUSC cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg25427524 chr10:38739819 LOC399744 0.59 10.49 0.5 1.97e-22 Extrinsic epigenetic age acceleration; LUSC cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg13319975 chr6:146136371 FBXO30 0.45 6.71 0.34 8.28e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9788721 1.000 rs931794 chr15:78826180 G/A cg06917634 chr15:78832804 PSMA4 0.48 6.51 0.34 2.8e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs7267979 0.933 rs2424708 chr20:25281398 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 17.67 0.69 8.86e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3768617 0.510 rs1886500 chr1:183095048 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs7584330 0.554 rs79213383 chr2:238426890 A/G cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.77 0.39 9.83e-14 Blood metabolite levels; LUSC cis rs9318086 0.673 rs7981928 chr13:24435180 T/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.43 6.38 0.33 5.79e-10 Myopia (pathological); LUSC cis rs11809207 0.903 rs17257148 chr1:26526348 G/C cg00300879 chr1:26503847 CNKSR1 0.32 6.37 0.33 6.17e-10 Height; LUSC cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs2282300 0.739 rs1717772 chr11:30340133 C/T cg25418670 chr11:30344373 C11orf46 -0.64 -9.23 -0.45 3.29e-18 Morning vs. evening chronotype; LUSC cis rs11625487 0.609 rs74063385 chr14:77966859 C/T cg16049707 chr14:77965284 ISM2 -0.6 -6.56 -0.34 2.01e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg03676636 chr4:99064102 C4orf37 0.36 7.7 0.39 1.5700000000000001e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12681288 0.792 rs4735972 chr8:998618 A/C cg04851639 chr8:1020857 NA -0.36 -7.68 -0.39 1.81e-13 Schizophrenia; LUSC cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg18850127 chr7:39170497 POU6F2 0.65 9.91 0.48 1.82e-20 IgG glycosylation; LUSC cis rs2120019 0.938 rs8030089 chr15:75290377 C/T cg09165964 chr15:75287851 SCAMP5 -1.12 -18.05 -0.7 2.72e-51 Blood trace element (Zn levels); LUSC cis rs3772130 0.886 rs9825248 chr3:121568711 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.7 10.02 0.48 7.94e-21 Cognitive performance; LUSC cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs1018836 0.544 rs10112371 chr8:91457626 C/T cg16814680 chr8:91681699 NA 0.48 6.84 0.35 3.71e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9814567 0.806 rs55835132 chr3:134325256 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.27 -0.56 8.26e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15506890 chr2:3487001 NA -0.58 -9.58 -0.46 2.23e-19 Neurofibrillary tangles; LUSC cis rs10276381 0.786 rs10272155 chr7:28246989 A/G cg23620719 chr7:28220237 JAZF1 0.64 6.7 0.34 8.86e-11 Crohn's disease; LUSC cis rs9420 0.884 rs673344 chr11:57657141 G/A cg23127183 chr11:57508653 C11orf31 0.51 7.28 0.37 2.44e-12 Schizophrenia; LUSC cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 12.9 0.58 3.54e-31 Platelet count; LUSC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg06850241 chr22:41845214 NA -0.31 -5.74 -0.3 2.1e-8 Vitiligo; LUSC cis rs7215564 0.558 rs4889876 chr17:78657071 T/G cg09596252 chr17:78655493 RPTOR 0.55 6.04 0.31 4.18e-9 Myopia (pathological); LUSC cis rs7584330 0.744 rs10929235 chr2:238380272 A/G cg14458575 chr2:238380390 NA 0.85 13.72 0.6 2.86e-34 Prostate cancer; LUSC cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg18132916 chr6:79620363 NA -0.41 -6.28 -0.32 1.06e-9 Intelligence (multi-trait analysis); LUSC cis rs4964805 0.954 rs11111786 chr12:104189057 T/C cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC cis rs1595825 0.786 rs75415672 chr2:198535679 G/A cg00982548 chr2:198649783 BOLL -0.53 -6.55 -0.34 2.2e-10 Ulcerative colitis; LUSC cis rs11997175 0.597 rs4472473 chr8:33610255 A/G ch.8.33884649F chr8:33765107 NA 0.41 6.47 0.33 3.47e-10 Body mass index; LUSC cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.51 7.04 0.36 1.07e-11 Multiple sclerosis; LUSC cis rs2070488 0.775 rs1073506 chr3:38566235 G/T cg24069376 chr3:38537580 EXOG -0.34 -6.6 -0.34 1.65e-10 Electrocardiographic conduction measures; LUSC cis rs727505 1.000 rs56356267 chr7:124557549 A/G cg23710748 chr7:124431027 NA -0.42 -7.58 -0.38 3.43e-13 Lewy body disease; LUSC cis rs9653442 0.564 rs2309753 chr2:100775920 C/A cg22139774 chr2:100720529 AFF3 -0.42 -7.25 -0.37 2.96e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC trans rs1973993 0.662 rs2057427 chr1:96888897 C/G cg10631902 chr5:14652156 NA -0.54 -8.04 -0.4 1.63e-14 Weight; LUSC cis rs9517320 1.000 rs7996093 chr13:99133092 T/C cg07423050 chr13:99094983 FARP1 0.33 6.37 0.33 6.21e-10 Longevity; LUSC cis rs3126085 0.877 rs10888472 chr1:152206896 C/G cg26876637 chr1:152193138 HRNR -0.42 -5.72 -0.3 2.34e-8 Atopic dermatitis; LUSC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg06600287 chr1:53387719 ECHDC2 0.28 5.68 0.3 3.01e-8 Monocyte count; LUSC cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg13531842 chr10:38383804 ZNF37A -0.43 -6.55 -0.34 2.17e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs7267979 1.000 rs2387880 chr20:25377787 T/C cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg26668828 chr6:292823 DUSP22 -0.51 -7.71 -0.39 1.47e-13 Menopause (age at onset); LUSC cis rs1198872 0.503 rs1627163 chr2:10954844 A/G cg15705551 chr2:10952987 PDIA6 0.41 5.8 0.3 1.52e-8 Cardiac Troponin-T levels; LUSC cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg05294307 chr14:35346193 BAZ1A -0.6 -6.98 -0.36 1.63e-11 Psoriasis; LUSC cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.96e-13 Motion sickness; LUSC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21659725 chr3:3221576 CRBN -0.89 -18.1 -0.7 1.6e-51 Intelligence (multi-trait analysis); LUSC cis rs12618769 0.625 rs3769733 chr2:99100716 A/G cg10123293 chr2:99228465 UNC50 0.45 7.26 0.37 2.67e-12 Bipolar disorder; LUSC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg14664628 chr15:75095509 CSK -0.42 -6.04 -0.31 4.06e-9 Caffeine consumption; LUSC cis rs2219968 1.000 rs4639505 chr8:78971658 A/G cg00738934 chr8:78996279 NA 0.35 6.32 0.33 8.21e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9300255 0.507 rs1615350 chr12:123650335 C/T cg13010344 chr12:123464640 ARL6IP4 -0.47 -7.04 -0.36 1.11e-11 Neutrophil percentage of white cells; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg24829409 chr8:58192753 C8orf71 -0.51 -5.98 -0.31 5.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs72781680 0.898 rs72781639 chr2:24204148 C/G cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs7179456 0.547 rs6494036 chr15:59015961 A/T cg05156742 chr15:59063176 FAM63B 0.52 7.52 0.38 5.25e-13 Asperger disorder; LUSC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs6665290 0.904 rs1045286 chr1:227179037 A/C cg10327440 chr1:227177885 CDC42BPA 1.21 40.72 0.91 1.46e-131 Myeloid white cell count; LUSC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg25838465 chr1:92012736 NA -0.75 -15.45 -0.65 5.22e-41 Breast cancer; LUSC cis rs977987 0.806 rs8051407 chr16:75448659 A/G cg03315344 chr16:75512273 CHST6 0.48 8.92 0.44 3.16e-17 Dupuytren's disease; LUSC cis rs2953145 0.545 rs2975755 chr2:241524919 G/A cg07929629 chr2:241523174 NA 0.63 11.67 0.54 1.23e-26 Bipolar disorder; LUSC cis rs11711311 1.000 rs62268169 chr3:113493860 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.62 0.34 1.39e-10 IgG glycosylation; LUSC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg23711669 chr6:146136114 FBXO30 -0.82 -14.69 -0.63 5.14e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.92 0.44 3.11e-17 Hip circumference adjusted for BMI; LUSC cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.38 0.64 9.49e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs12579753 0.912 rs4417392 chr12:82158722 C/A cg21231944 chr12:82153410 PPFIA2 -0.4 -6.31 -0.33 8.73e-10 Resting heart rate; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg25072359 chr17:41440525 NA 0.64 9.06 0.44 1.15e-17 Menopause (age at onset); LUSC cis rs2404602 0.692 rs67570291 chr15:77020502 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.88 -0.4 4.75e-14 Blood metabolite levels; LUSC cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs868036 1.000 rs884202 chr15:68054388 G/A cg08079166 chr15:68083412 MAP2K5 -0.42 -8.61 -0.43 2.9e-16 Restless legs syndrome; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg18404041 chr3:52824283 ITIH1 -0.63 -11.65 -0.54 1.46e-26 Bipolar disorder; LUSC cis rs1185460 0.967 rs1786685 chr11:118938957 G/A cg23280166 chr11:118938394 VPS11 0.48 7.57 0.38 3.62e-13 Coronary artery disease; LUSC cis rs10743315 0.557 rs117033327 chr12:19373040 G/T cg02471346 chr12:19282374 PLEKHA5 0.76 6.02 0.31 4.61e-9 Gut microbiota (bacterial taxa); LUSC cis rs11997175 0.603 rs66828270 chr8:33790155 C/G ch.8.33884649F chr8:33765107 NA 0.51 7.81 0.39 7.52e-14 Body mass index; LUSC cis rs9473147 0.516 rs13212790 chr6:47576367 T/C cg02130027 chr6:47444894 CD2AP 0.36 5.72 0.3 2.33e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg04414720 chr1:150670196 GOLPH3L -0.49 -7.7 -0.39 1.55e-13 Tonsillectomy; LUSC cis rs754466 0.580 rs1866437 chr10:79526766 A/G cg17075019 chr10:79541650 NA -0.75 -12.36 -0.56 3.79e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7246657 0.525 rs997516 chr19:37474264 T/C cg23950597 chr19:37808831 NA -0.52 -5.66 -0.3 3.33e-8 Coronary artery calcification; LUSC cis rs9527 0.545 rs7915816 chr10:104881750 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs870825 0.616 rs7678849 chr4:185648868 T/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs7660520 1.000 rs7660520 chr4:183745321 C/T cg20639618 chr4:183729073 NA 0.38 5.66 0.3 3.28e-8 Pediatric autoimmune diseases; LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg08132940 chr7:1081526 C7orf50 -0.5 -5.93 -0.31 7.41e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs826838 0.806 rs826873 chr12:39121305 G/A cg26384229 chr12:38710491 ALG10B -0.84 -15.73 -0.65 4.2e-42 Heart rate; LUSC cis rs4343996 0.935 rs4385365 chr7:3360860 C/T cg21248987 chr7:3385318 SDK1 -0.38 -6.5 -0.34 2.92e-10 Motion sickness; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg25767906 chr1:53392781 SCP2 -0.51 -9.52 -0.46 3.54e-19 Monocyte count; LUSC cis rs7582180 0.629 rs4851297 chr2:100949571 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.59 -0.43 3.48e-16 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg00784671 chr22:46762841 CELSR1 -0.51 -6.44 -0.33 4.21e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg05855489 chr10:104503620 C10orf26 -0.69 -10.14 -0.49 2.99e-21 Allergic disease (asthma, hay fever or eczema); LUSC trans rs1973993 0.717 rs55650017 chr1:96952142 G/A cg10631902 chr5:14652156 NA -0.45 -6.66 -0.34 1.15e-10 Weight; LUSC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg21770322 chr7:97807741 LMTK2 0.44 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs7568458 0.684 rs6731700 chr2:85760991 C/G cg23752985 chr2:85803571 VAMP8 0.33 6.52 0.34 2.61e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg13699009 chr12:122356056 WDR66 0.5 7.74 0.39 1.21e-13 Mean corpuscular volume; LUSC cis rs17270561 0.639 rs9356989 chr6:25781950 A/G cg16482183 chr6:26056742 HIST1H1C 0.6 8.33 0.41 2.13e-15 Iron status biomarkers; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg11816918 chr18:2656305 SMCHD1 0.4 6.03 0.31 4.26e-9 Schizophrenia; LUSC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg22549504 chr19:17448937 GTPBP3 -0.57 -7.54 -0.38 4.56e-13 Systemic lupus erythematosus; LUSC cis rs2996428 0.601 rs10909804 chr1:3770929 A/G cg13057898 chr1:3703894 LRRC47 -0.5 -8.91 -0.44 3.45e-17 Red cell distribution width; LUSC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg22968622 chr17:43663579 NA -0.78 -12.04 -0.55 5.64e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs11105298 0.891 rs11105310 chr12:89918677 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.42 -0.38 1.01e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7520050 0.807 rs28378621 chr1:46189554 T/C cg06784218 chr1:46089804 CCDC17 0.3 5.93 0.31 7.59e-9 Red blood cell count;Reticulocyte count; LUSC cis rs12908161 0.920 rs12904605 chr15:85201419 T/C cg17173187 chr15:85201210 NMB 0.5 9.51 0.46 4.01e-19 Schizophrenia; LUSC cis rs4664308 1.000 rs62175517 chr2:160911575 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -11.33 -0.53 2.16e-25 Idiopathic membranous nephropathy; LUSC cis rs643955 0.609 rs13259465 chr8:9982953 C/G cg27411982 chr8:10470053 RP1L1 -0.4 -5.82 -0.3 1.37e-8 Systemic lupus erythematosus; LUSC cis rs6545883 0.894 rs6734628 chr2:61451260 T/C cg15711740 chr2:61764176 XPO1 0.44 6.61 0.34 1.55e-10 Tuberculosis; LUSC cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.85 0.35 3.47e-11 Rheumatoid arthritis; LUSC cis rs1506636 0.646 rs805776 chr7:123212561 T/C cg03229431 chr7:123269106 ASB15 -0.59 -8.87 -0.44 4.37e-17 Plateletcrit;Platelet count; LUSC cis rs10782582 0.609 rs1796810 chr1:76403305 C/T cg03433033 chr1:76189801 ACADM -0.41 -6.13 -0.32 2.47e-9 Daytime sleep phenotypes; LUSC cis rs7568458 0.709 rs11895401 chr2:85753847 C/T cg23752985 chr2:85803571 VAMP8 0.31 6.06 0.31 3.7e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.64 -0.57 3.39e-30 Platelet count; LUSC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg18404041 chr3:52824283 ITIH1 0.37 6.69 0.34 9.59e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg25767906 chr1:53392781 SCP2 -0.32 -5.64 -0.3 3.56e-8 Monocyte count; LUSC cis rs7927771 0.524 rs3758655 chr11:47703943 T/C cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.87e-10 Subjective well-being; LUSC cis rs4901869 0.897 rs12878587 chr14:59339378 C/G cg02291164 chr14:59296302 NA 0.58 11.11 0.52 1.33e-24 Panic disorder; LUSC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg21466736 chr12:48725269 NA 0.31 5.77 0.3 1.85e-8 Glycated hemoglobin levels; LUSC trans rs6601327 0.606 rs9644707 chr8:9590116 A/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.43 -0.33 4.36e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs36093844 0.752 rs77497327 chr11:85586941 G/A cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs1775715 0.737 rs55859032 chr10:32213239 C/T cg26784012 chr10:32216390 ARHGAP12 0.44 7.51 0.38 5.48e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6574644 1.000 rs7153538 chr14:81779507 G/T cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs524023 0.958 rs11231825 chr11:64360274 T/C cg07220939 chr11:64358617 SLC22A12 -0.22 -5.76 -0.3 1.91e-8 Urate levels in obese individuals; LUSC cis rs9411298 0.630 rs9411299 chr9:139938793 C/G cg14024893 chr9:139943146 ENTPD2 -0.56 -9.77 -0.47 5.53e-20 Monocyte percentage of white cells; LUSC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg08219700 chr8:58056026 NA 0.49 6.08 0.32 3.35e-9 Developmental language disorder (linguistic errors); LUSC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.47e-8 Extrinsic epigenetic age acceleration; LUSC trans rs76248362 1.000 rs7324410 chr13:24437465 G/A cg26511321 chr7:27196790 HOXA7 0.53 6.18 0.32 1.87e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs34779708 0.931 rs2001893 chr10:35300623 G/A cg04310649 chr10:35416472 CREM -0.4 -6.27 -0.32 1.13e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs698813 0.674 rs4953080 chr2:44500849 C/A cg00619915 chr2:44497795 NA -0.52 -7.01 -0.36 1.3e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.25 0.32 1.25e-9 Platelet count; LUSC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11890956 chr21:40555474 PSMG1 0.98 16.67 0.67 8e-46 Cognitive function; LUSC cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs2658782 0.951 rs2608215 chr11:93148817 G/A cg15737290 chr11:93063684 CCDC67 0.64 7.99 0.4 2.27e-14 Pulmonary function decline; LUSC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg16434002 chr17:42200994 HDAC5 -0.45 -6.08 -0.32 3.24e-9 Total body bone mineral density; LUSC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg03709012 chr19:19516395 GATAD2A 0.82 13.28 0.59 1.32e-32 Tonsillectomy; LUSC trans rs7824557 0.767 rs2060463 chr8:11161610 T/G cg08975724 chr8:8085496 FLJ10661 0.44 6.51 0.34 2.81e-10 Retinal vascular caliber; LUSC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg10360323 chr17:41437877 NA 0.41 5.74 0.3 2.17e-8 Menopause (age at onset); LUSC cis rs7833986 1.000 rs66796428 chr8:57094797 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 9.2 0.45 3.84e-18 Height; LUSC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg25174290 chr11:3078921 CARS 0.57 8.58 0.42 3.72e-16 Type 2 diabetes; LUSC cis rs17102423 0.530 rs4902359 chr14:65542790 G/A cg11161011 chr14:65562177 MAX -0.7 -10.93 -0.51 5.69e-24 Obesity-related traits; LUSC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg08677398 chr8:58056175 NA 0.52 6.08 0.32 3.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.647 rs10851889 chr15:77023336 C/T cg23625390 chr15:77176239 SCAPER -0.65 -9.87 -0.48 2.56e-20 Blood metabolite levels; LUSC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg03526776 chr6:41159608 TREML2 0.32 6.38 0.33 5.92e-10 Alzheimer's disease (late onset); LUSC cis rs7615952 0.800 rs13086460 chr3:125646417 C/T cg02807482 chr3:125708958 NA -0.48 -5.7 -0.3 2.63e-8 Blood pressure (smoking interaction); LUSC cis rs57502260 1.000 rs56312530 chr11:68219415 G/A cg20283391 chr11:68216788 NA -0.59 -5.72 -0.3 2.42e-8 Total body bone mineral density (age 45-60); LUSC cis rs7927592 0.913 rs11228293 chr11:68384646 T/C cg16797656 chr11:68205561 LRP5 0.38 6.19 0.32 1.77e-9 Total body bone mineral density; LUSC cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg21535247 chr6:8435926 SLC35B3 0.56 8.57 0.42 3.79e-16 Motion sickness; LUSC trans rs7726839 0.540 rs3749615 chr5:601485 C/T cg25482853 chr8:67687455 SGK3 1.11 15.63 0.65 9.88e-42 Obesity-related traits; LUSC cis rs7712401 0.601 rs431878 chr5:122261791 G/T cg19077854 chr5:122220652 SNX24 -0.44 -9.66 -0.47 1.28e-19 Mean platelet volume; LUSC cis rs9865818 0.669 rs13079689 chr3:188102112 A/T cg23651889 chr3:188115336 LPP -0.38 -5.76 -0.3 1.91e-8 Allergic sensitization; LUSC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg09998033 chr7:158218633 PTPRN2 -0.61 -9.8 -0.47 4.38e-20 Obesity-related traits; LUSC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Melanoma; LUSC cis rs10761482 0.861 rs4620673 chr10:62104704 A/G cg18175470 chr10:62150864 ANK3 0.46 6.56 0.34 2.02e-10 Schizophrenia; LUSC trans rs13008689 0.875 rs12616139 chr2:8522651 C/T cg21637561 chr17:37074902 LASP1 0.35 6.05 0.31 3.91e-9 Longevity; LUSC trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg08975724 chr8:8085496 FLJ10661 -0.51 -7.3 -0.37 2.14e-12 Neuroticism; LUSC cis rs72848980 0.512 rs56984020 chr10:105386275 C/A cg00126946 chr10:105363258 SH3PXD2A 0.39 5.76 0.3 1.9e-8 White matter hyperintensity burden; LUSC cis rs4499344 0.633 rs259239 chr19:33141090 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 12.14 0.55 2.37e-28 Mean platelet volume; LUSC cis rs116988415 0.584 rs4902310 chr14:65241906 T/C cg25083366 chr14:65239357 SPTB 0.66 6.37 0.33 6.41e-10 Daytime sleep phenotypes; LUSC cis rs2115630 0.967 rs12595786 chr15:85336670 T/C cg09876464 chr15:85330779 ZNF592 0.36 6.71 0.34 8.3e-11 P wave terminal force; LUSC cis rs9296092 0.517 rs9461877 chr6:33516667 C/T cg13560919 chr6:33536144 NA -0.82 -15.45 -0.65 5.48e-41 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2976388 0.692 rs2585175 chr8:143781289 G/C cg17252645 chr8:143867129 LY6D 0.39 6.71 0.34 8.6e-11 Urinary tract infection frequency; LUSC cis rs34546498 1 rs34546498 chr6:26961280 C/T cg26958806 chr6:27640298 NA 0.78 5.84 0.3 1.21e-8 Breast cancer; LUSC cis rs9527 0.640 rs7089061 chr10:104723015 C/A cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.46 1.42e-18 Arsenic metabolism; LUSC cis rs9300255 0.537 rs1618679 chr12:123650714 A/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.15 -0.32 2.26e-9 Neutrophil percentage of white cells; LUSC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.57 0.42 3.86e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1322512 0.917 rs2623953 chr6:152965857 A/G cg27316956 chr6:152958899 SYNE1 -0.37 -6.34 -0.33 7.64e-10 Tonometry; LUSC cis rs35123781 1.000 rs34510678 chr5:139064835 C/T cg00976381 chr5:138713954 SLC23A1 -0.38 -5.73 -0.3 2.23e-8 Schizophrenia; LUSC cis rs1775715 0.674 rs2778670 chr10:32161676 G/A cg03015672 chr10:32216066 ARHGAP12 0.33 6.01 0.31 4.87e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6545883 0.965 rs1562308 chr2:61768421 A/C cg15711740 chr2:61764176 XPO1 -0.51 -7.98 -0.4 2.31e-14 Tuberculosis; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg17178900 chr1:205818956 PM20D1 0.84 14.53 0.62 2.02e-37 Menarche (age at onset); LUSC trans rs853679 1.000 rs1419183 chr6:28242794 A/C cg01620082 chr3:125678407 NA -0.51 -6.24 -0.32 1.33e-9 Depression; LUSC cis rs11190604 1.000 rs2295779 chr10:102296061 A/G cg23241863 chr10:102295624 HIF1AN 0.48 5.9 0.31 8.71e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg19717773 chr7:2847554 GNA12 -0.37 -6.07 -0.32 3.53e-9 Height; LUSC cis rs17345786 0.520 rs1476123 chr3:101313413 C/G cg12386194 chr3:101231763 SENP7 0.39 5.64 0.3 3.58e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC trans rs853679 0.607 rs34878803 chr6:28250179 T/C cg06606381 chr12:133084897 FBRSL1 -0.95 -9.13 -0.45 6.49e-18 Depression; LUSC cis rs6964587 0.869 rs2374519 chr7:91541481 T/C cg22709100 chr7:91322751 NA -0.4 -5.84 -0.3 1.21e-8 Breast cancer; LUSC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.43 -0.38 9.29e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs459571 0.834 rs379417 chr9:136890704 G/A cg01294253 chr9:136912663 BRD3 0.36 6.24 0.32 1.34e-9 Platelet distribution width; LUSC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg27532560 chr4:187881888 NA 0.38 6.32 0.33 8.18e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg12311346 chr5:56204834 C5orf35 -0.87 -12.41 -0.56 2.44e-29 Initial pursuit acceleration; LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg03576123 chr11:487126 PTDSS2 -1.0 -10.64 -0.5 6.03e-23 Body mass index; LUSC trans rs2243480 1.000 rs34529418 chr7:65403209 A/G cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs6500602 0.702 rs4786511 chr16:4571645 C/T cg08645402 chr16:4508243 NA 0.53 8.98 0.44 2.03e-17 Schizophrenia; LUSC cis rs6987853 0.787 rs2974314 chr8:42457043 C/T cg09913449 chr8:42400586 C8orf40 0.46 7.72 0.39 1.35e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs2073300 0.536 rs6137947 chr20:23414630 C/A cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7851660 0.805 rs7038998 chr9:100662396 C/G cg13688889 chr9:100608707 NA -0.54 -8.49 -0.42 6.73e-16 Strep throat; LUSC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.47 -0.38 6.93e-13 Height; LUSC trans rs72792324 1.000 rs4151697 chr5:140743661 C/T cg16996281 chr11:119217884 MFRP;C1QTNF5 0.43 5.96 0.31 6.57e-9 Mean platelet volume; LUSC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg02551604 chr5:131831745 NA -0.4 -6.27 -0.32 1.1e-9 Asthma (sex interaction); LUSC cis rs3125734 0.633 rs6479804 chr10:64048327 T/C cg19640130 chr10:64028056 RTKN2 -0.38 -6.63 -0.34 1.35e-10 Rheumatoid arthritis; LUSC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg10356904 chr22:49881777 NA -0.33 -7.51 -0.38 5.49e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10752881 1.000 rs10797802 chr1:182973158 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.69 -10.76 -0.51 2.31e-23 Colorectal cancer; LUSC cis rs422249 0.720 rs174455 chr11:61656117 A/G cg01500311 chr11:61656094 FADS3 -0.44 -8.62 -0.43 2.69e-16 Trans fatty acid levels; LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.77 0.47 5.19e-20 Bipolar disorder; LUSC cis rs10193935 1.000 rs13391906 chr2:42538617 C/G cg27598129 chr2:42591480 NA -0.6 -8.17 -0.41 6.36e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg07507251 chr3:52567010 NT5DC2 0.32 6.13 0.32 2.44e-9 Bipolar disorder; LUSC cis rs929596 0.793 rs2741046 chr2:234580249 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -6.96 -0.36 1.82e-11 Total bilirubin levels in HIV-1 infection; LUSC cis rs826838 1.000 rs1393537 chr12:38920961 C/T cg26384229 chr12:38710491 ALG10B 0.93 17.43 0.69 7.74e-49 Heart rate; LUSC cis rs751728 1.000 rs755496 chr6:33734376 C/G cg25922239 chr6:33757077 LEMD2 0.51 7.5 0.38 5.69e-13 Crohn's disease; LUSC cis rs9469578 1.000 rs60447213 chr6:33715159 G/T cg18708504 chr6:33715942 IP6K3 0.72 8.8 0.43 7.52e-17 Phosphorus levels; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg14004847 chr7:1930337 MAD1L1 -0.67 -10.94 -0.51 5.07e-24 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg08859206 chr1:53392774 SCP2 0.52 9.03 0.44 1.44e-17 Monocyte count; LUSC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg24733560 chr20:60626293 TAF4 0.42 7.82 0.39 6.93e-14 Body mass index; LUSC cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.57 0.46 2.47e-19 Mean platelet volume; LUSC cis rs11158026 0.603 rs66820631 chr14:55465553 T/A cg04306507 chr14:55594613 LGALS3 0.39 7.12 0.36 6.46e-12 Parkinson's disease; LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg02574844 chr11:5959923 NA -0.44 -6.32 -0.33 8.18e-10 DNA methylation (variation); LUSC cis rs6696846 0.905 rs11240349 chr1:205041015 G/A cg00857998 chr1:205179979 DSTYK 0.63 9.56 0.46 2.64e-19 Red blood cell count; LUSC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg22834771 chr12:69754056 YEATS4 0.46 5.85 0.3 1.17e-8 Response to diuretic therapy; LUSC cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs9815354 0.812 rs77047799 chr3:41958895 T/C cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs4363385 0.647 rs56412380 chr1:153000705 T/C cg00922841 chr1:152955080 SPRR1A -0.39 -6.5 -0.33 2.97e-10 Inflammatory skin disease; LUSC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg16928487 chr17:17741425 SREBF1 -0.34 -6.29 -0.33 1.01e-9 Total body bone mineral density; LUSC trans rs7824557 0.527 rs2572369 chr8:11238597 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.55 -0.38 4.07e-13 Retinal vascular caliber; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg21280719 chr6:42927975 GNMT -0.31 -7.73 -0.39 1.24e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11648785 0.777 rs12932473 chr16:90100389 C/T cg16611967 chr16:90144006 NA 0.44 5.77 0.3 1.86e-8 Tanning; LUSC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg22907277 chr7:1156413 C7orf50 0.7 8.21 0.41 5e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2637266 0.663 rs846581 chr10:78497984 C/T cg18941641 chr10:78392320 NA 0.4 7.28 0.37 2.35e-12 Pulmonary function; LUSC cis rs62458065 0.850 rs7785999 chr7:32461262 G/T cg20159608 chr7:32802032 NA -0.62 -7.32 -0.37 1.87e-12 Metabolite levels (HVA/MHPG ratio); LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg08280861 chr8:58055591 NA -0.58 -7.1 -0.36 7.46e-12 Developmental language disorder (linguistic errors); LUSC trans rs12406019 0.548 rs11579434 chr1:78610022 T/C cg20826526 chr3:156266748 SSR3 -0.46 -6.83 -0.35 3.95e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8017423 0.935 rs7144335 chr14:90732280 A/G cg04374321 chr14:90722782 PSMC1 -0.7 -10.68 -0.5 4.18e-23 Mortality in heart failure; LUSC cis rs2274273 0.682 rs10145268 chr14:55504514 T/C cg04306507 chr14:55594613 LGALS3 0.51 11.06 0.52 1.92e-24 Protein biomarker; LUSC cis rs9914988 0.943 rs3181215 chr17:27077331 C/T cg09479241 chr17:27052676 TLCD1 -0.4 -5.65 -0.3 3.37e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs12368653 0.666 rs799267 chr12:58113158 C/T cg15848620 chr12:58087721 OS9 -0.4 -5.74 -0.3 2.12e-8 Multiple sclerosis; LUSC cis rs12530845 1.000 rs56060450 chr7:135331777 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg13939156 chr17:80058883 NA 0.33 6.48 0.33 3.24e-10 Life satisfaction; LUSC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg02503808 chr4:7069936 GRPEL1 1.02 14.65 0.63 7.03e-38 Monocyte percentage of white cells; LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.95 0.31 6.92e-9 Menopause (age at onset); LUSC cis rs6964587 0.967 rs7781221 chr7:91664645 A/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.23e-8 Breast cancer; LUSC trans rs79976124 0.842 rs7760550 chr6:66628788 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.65 8.05 0.4 1.51e-14 Type 2 diabetes; LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.58 9.81 0.47 4.01e-20 Bipolar disorder; LUSC cis rs11608355 1.000 rs7958625 chr12:109869218 A/T cg19025524 chr12:109796872 NA -0.37 -5.67 -0.3 3.16e-8 Neuroticism; LUSC cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg17063962 chr7:91808500 NA 0.59 9.43 0.46 7.37e-19 Breast cancer; LUSC cis rs66887589 0.967 rs7678973 chr4:120511817 T/C cg24375607 chr4:120327624 NA -0.47 -7.25 -0.37 2.96e-12 Diastolic blood pressure; LUSC trans rs61931739 0.817 rs592857 chr12:34197673 T/G cg24313572 chr1:56050060 NA -0.29 -5.96 -0.31 6.59e-9 Morning vs. evening chronotype; LUSC cis rs1150668 0.835 rs203869 chr6:28040819 T/A cg21251018 chr6:28226885 NKAPL 0.31 5.83 0.3 1.3e-8 Pubertal anthropometrics; LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.83e-11 Alzheimer's disease; LUSC cis rs3008870 0.755 rs1570838 chr1:67403315 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.32 0.56 5.19e-29 Lymphocyte percentage of white cells; LUSC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg16325326 chr1:53192061 ZYG11B -0.99 -19.96 -0.74 6.94e-59 Monocyte count; LUSC cis rs7520050 0.778 rs2934857 chr1:46039612 A/G cg15605315 chr1:45957053 TESK2 -0.41 -6.09 -0.32 3.12e-9 Red blood cell count;Reticulocyte count; LUSC cis rs4642101 0.561 rs7638333 chr3:12806142 T/C cg05775895 chr3:12838266 CAND2 0.48 7.41 0.38 1.02e-12 QRS complex (12-leadsum); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08102658 chr17:79283123 C17orf55 0.7 6.05 0.31 3.87e-9 Cognitive performance; LUSC cis rs6969780 1.000 rs73071550 chr7:27149099 T/C cg26364809 chr7:27145159 NA -0.59 -5.91 -0.31 8.35e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg21138405 chr5:131827807 IRF1 -0.34 -6.01 -0.31 4.93e-9 Breast cancer;Mosquito bite size; LUSC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg13531842 chr10:38383804 ZNF37A -0.44 -6.85 -0.35 3.62e-11 Extrinsic epigenetic age acceleration; LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg04518342 chr5:131593106 PDLIM4 0.55 10.37 0.49 4.93e-22 Acylcarnitine levels; LUSC cis rs10782582 0.593 rs11576534 chr1:76112751 C/T cg03433033 chr1:76189801 ACADM -0.47 -7.31 -0.37 1.94e-12 Daytime sleep phenotypes; LUSC cis rs11676348 0.846 rs11677534 chr2:219007060 T/C cg00012203 chr2:219082015 ARPC2 -0.56 -9.08 -0.45 9.47e-18 Ulcerative colitis; LUSC cis rs80282103 0.764 rs12247818 chr10:1110464 G/A cg18964960 chr10:1102726 WDR37 0.69 5.88 0.31 1e-8 Glomerular filtration rate (creatinine); LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg21548813 chr6:291882 DUSP22 -0.51 -7.64 -0.39 2.36e-13 Menopause (age at onset); LUSC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg21918786 chr6:109611834 NA -0.36 -6.19 -0.32 1.8e-9 Reticulocyte fraction of red cells; LUSC cis rs752010 0.806 rs943375 chr1:42092152 A/G cg06885757 chr1:42089581 HIVEP3 0.49 10.18 0.49 2.32e-21 Lupus nephritis in systemic lupus erythematosus; LUSC trans rs11098499 0.604 rs10022185 chr4:120571765 C/G cg25214090 chr10:38739885 LOC399744 0.5 7.32 0.37 1.88e-12 Corneal astigmatism; LUSC cis rs1014246 0.848 rs10787715 chr10:118459571 C/T cg14919929 chr10:118506882 NA 0.46 7.17 0.37 4.93e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs13253111 1.000 rs13253111 chr8:28061974 C/T cg26534493 chr8:28060551 NA -0.46 -8.96 -0.44 2.36e-17 Childhood body mass index; LUSC cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg14582100 chr15:45693742 SPATA5L1 0.59 10.69 0.5 4.01e-23 Homoarginine levels; LUSC cis rs4595586 0.545 rs12810822 chr12:39391807 T/A cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs7617480 0.585 rs7373072 chr3:48960017 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.62 9.54 0.46 3.01e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg22508957 chr16:3507546 NAT15 -0.42 -6.68 -0.34 1.03e-10 Body mass index (adult); LUSC cis rs12464483 0.524 rs1348898 chr2:30888026 C/A cg17749961 chr2:30669863 LCLAT1 0.62 7.62 0.38 2.62e-13 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs6121246 0.609 rs2149281 chr20:30417918 G/A cg13852791 chr20:30311386 BCL2L1 0.9 13.39 0.59 4.82e-33 Mean corpuscular hemoglobin; LUSC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg03233332 chr7:66118400 NA -0.39 -5.86 -0.31 1.12e-8 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17571279 chr8:22526738 BIN3 -0.53 -6.21 -0.32 1.57e-9 Bipolar disorder and schizophrenia; LUSC cis rs240764 0.578 rs9399688 chr6:101215786 C/T cg09795085 chr6:101329169 ASCC3 0.43 6.1 0.32 2.92e-9 Neuroticism; LUSC cis rs1568889 0.838 rs7131053 chr11:28143312 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.7 0.57 2.01e-30 Bipolar disorder; LUSC cis rs7808935 0.628 rs72598551 chr7:27939885 C/T cg22168087 chr7:27702803 HIBADH 0.7 8.29 0.41 2.84e-15 Prostate cancer; LUSC cis rs950027 0.620 rs1719245 chr15:45623782 T/C cg14582100 chr15:45693742 SPATA5L1 0.46 8.52 0.42 5.49e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs6963495 0.745 rs73192151 chr7:105211876 A/G cg19920283 chr7:105172520 RINT1 0.58 5.94 0.31 7.27e-9 Bipolar disorder (body mass index interaction); LUSC trans rs637571 0.544 rs12361552 chr11:65701204 G/A cg17712092 chr4:129076599 LARP1B -0.86 -13.46 -0.59 2.74e-33 Eosinophil percentage of white cells; LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.5 6.23 0.32 1.4e-9 Renal function-related traits (BUN); LUSC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg25110423 chr6:41068646 NFYA;LOC221442 0.55 8.64 0.43 2.41e-16 Alzheimer's disease (late onset); LUSC trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg20587970 chr11:113659929 NA -1.23 -16.37 -0.67 1.18e-44 Hip circumference adjusted for BMI; LUSC cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg19077165 chr18:44547161 KATNAL2 0.42 6.33 0.33 7.85e-10 Personality dimensions; LUSC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg22029157 chr1:209979665 IRF6 -0.74 -9.33 -0.45 1.56e-18 Cleft lip with or without cleft palate; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg04141948 chr7:1023156 CYP2W1 0.28 5.73 0.3 2.19e-8 Longevity;Endometriosis; LUSC cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg08999081 chr20:33150536 PIGU 0.43 7.81 0.39 7.28e-14 Coronary artery disease; LUSC cis rs2486288 0.656 rs2461705 chr15:45570241 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.99 -0.4 2.21e-14 Glomerular filtration rate; LUSC cis rs7824557 0.583 rs6601585 chr8:11233659 A/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.75 -0.3 2e-8 Retinal vascular caliber; LUSC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC trans rs75804782 0.641 rs77448526 chr2:239353487 A/C cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.11e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.72 0.65 4.58e-42 Platelet count; LUSC cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg12927641 chr6:109611667 NA -0.34 -5.87 -0.31 1.04e-8 Reticulocyte fraction of red cells; LUSC cis rs12594515 1.000 rs8032361 chr15:45988553 T/C cg19682013 chr15:45996608 NA 0.39 6.0 0.31 5.09e-9 Waist circumference;Weight; LUSC cis rs1595825 0.945 rs16826320 chr2:198845623 T/C cg00982548 chr2:198649783 BOLL -0.57 -7.13 -0.36 6.43e-12 Ulcerative colitis; LUSC cis rs17270561 0.609 rs9358877 chr6:25739228 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg11301795 chr4:187892539 NA -0.8 -15.66 -0.65 7.98e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs4631830 0.900 rs10763588 chr10:51539762 G/T cg20129853 chr10:51489980 NA -0.33 -6.57 -0.34 1.95e-10 Prostate-specific antigen levels; LUSC cis rs6121246 0.865 rs6058421 chr20:30295013 G/C cg13852791 chr20:30311386 BCL2L1 0.88 11.94 0.55 1.3e-27 Mean corpuscular hemoglobin; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19977241 chr2:74692637 MOGS 0.72 6.02 0.31 4.56e-9 Cognitive performance; LUSC cis rs7937682 0.737 rs682239 chr11:111425105 A/G cg19812747 chr11:111475976 SIK2 0.42 6.34 0.33 7.4e-10 Primary sclerosing cholangitis; LUSC cis rs5758659 0.652 rs133324 chr22:42406371 C/A cg15557168 chr22:42548783 NA -0.33 -5.67 -0.3 3.03e-8 Cognitive function; LUSC cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.86 -0.35 3.3e-11 Menopause (age at onset); LUSC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg21963583 chr11:68658836 MRPL21 0.55 8.14 0.41 7.91e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7181230 1.000 rs7181230 chr15:40360741 A/G cg00868766 chr15:40364524 NA 0.34 6.13 0.32 2.46e-9 Dehydroepiandrosterone sulphate levels; LUSC cis rs71403859 0.568 rs12149489 chr16:71813780 G/T cg08717414 chr16:71523259 ZNF19 -0.58 -6.64 -0.34 1.24e-10 Post bronchodilator FEV1; LUSC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg06046430 chr4:77819534 ANKRD56 0.48 6.97 0.36 1.73e-11 Emphysema distribution in smoking; LUSC cis rs7828089 0.715 rs11136029 chr8:22253485 A/G cg12081754 chr8:22256438 SLC39A14 -0.6 -9.88 -0.48 2.29e-20 Verbal declarative memory; LUSC cis rs4925325 0.915 rs2427246 chr20:60517047 T/C cg12751644 chr20:60527061 NA -0.41 -7.12 -0.36 6.53e-12 Obesity-related traits; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg06877462 chr1:205807181 PM20D1 0.49 8.71 0.43 1.46e-16 Menarche (age at onset); LUSC cis rs2456568 0.548 rs10466334 chr11:93663512 A/G cg17595323 chr11:93583763 C11orf90 -0.32 -5.86 -0.31 1.13e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs8180040 0.966 rs807932 chr3:47354241 C/T cg27129171 chr3:47204927 SETD2 0.72 12.42 0.56 2.16e-29 Colorectal cancer; LUSC cis rs10089 1.000 rs2898096 chr5:127433214 C/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.9 -0.31 8.73e-9 Ileal carcinoids; LUSC cis rs7246967 0.541 rs74169641 chr19:22830576 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs12908161 1.000 rs62019469 chr15:85321220 T/C cg12863693 chr15:85201151 NMB 0.39 8.05 0.4 1.49e-14 Schizophrenia; LUSC cis rs4589502 1.000 rs4589502 chr15:67155069 C/T cg09911534 chr15:67153556 NA -0.56 -6.76 -0.35 6.28e-11 Lung cancer (smoking interaction); LUSC cis rs6005807 0.719 rs9625520 chr22:29037864 C/A cg12565055 chr22:29076175 TTC28 0.54 5.85 0.31 1.15e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -6.06 -0.31 3.68e-9 Longevity; LUSC cis rs2797160 0.967 rs1954360 chr6:126001064 A/G cg05901451 chr6:126070800 HEY2 -0.58 -8.59 -0.43 3.43e-16 Endometrial cancer; LUSC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg13628971 chr7:2884303 GNA12 0.45 6.43 0.33 4.32e-10 Height; LUSC cis rs3126085 0.935 rs4845431 chr1:152227977 A/G cg03465714 chr1:152285911 FLG -0.39 -5.64 -0.3 3.55e-8 Atopic dermatitis; LUSC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg07936489 chr17:37558343 FBXL20 -0.7 -9.74 -0.47 6.83e-20 Glomerular filtration rate (creatinine); LUSC cis rs2980439 0.607 rs2980419 chr8:8114141 A/T cg08975724 chr8:8085496 FLJ10661 0.65 9.66 0.47 1.27e-19 Neuroticism; LUSC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg24296786 chr1:45957014 TESK2 0.54 8.23 0.41 4.22e-15 High light scatter reticulocyte count; LUSC cis rs2742234 0.541 rs1879310 chr10:43734775 A/G cg15436174 chr10:43711423 RASGEF1A 0.43 7.09 0.36 8.12e-12 Hirschsprung disease; LUSC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs7903847 0.642 rs11189159 chr10:99113964 G/A cg20016023 chr10:99160130 RRP12 -0.29 -6.26 -0.32 1.17e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6686643 0.762 rs61800372 chr1:165611981 T/C cg16553119 chr1:165599451 MGST3 -0.46 -6.48 -0.33 3.32e-10 Total ventricular volume; LUSC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg00857998 chr1:205179979 DSTYK 0.64 9.87 0.48 2.45e-20 Mean corpuscular volume;Mean platelet volume; LUSC trans rs9409565 0.826 rs9409564 chr9:97248166 C/T cg05679027 chr9:99775184 HIATL2 -0.44 -6.16 -0.32 2.06e-9 Colorectal cancer (alcohol consumption interaction); LUSC cis rs1476670 0.710 rs4660763 chr1:44503576 T/C cg09470012 chr1:44509516 NA 0.29 5.66 0.3 3.33e-8 Eotaxin levels; LUSC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg11764359 chr7:65958608 NA 0.71 10.66 0.5 5.06e-23 Aortic root size; LUSC cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg02527881 chr3:46936655 PTH1R -0.71 -13.72 -0.6 2.77e-34 Birth weight; LUSC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg06008330 chr7:65541103 ASL -0.4 -6.22 -0.32 1.52e-9 Aortic root size; LUSC trans rs61931739 0.612 rs1906137 chr12:33939676 T/A cg13010199 chr12:38710504 ALG10B 0.4 6.04 0.31 4.15e-9 Morning vs. evening chronotype; LUSC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg04362960 chr10:104952993 NT5C2 0.58 9.29 0.45 2.02e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs738322 0.533 rs2284064 chr22:38547395 A/C cg25457927 chr22:38595422 NA -0.35 -6.97 -0.36 1.74e-11 Cutaneous nevi; LUSC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg09491104 chr22:46646882 C22orf40 -0.7 -9.18 -0.45 4.47e-18 LDL cholesterol;Cholesterol, total; LUSC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg12463550 chr7:65579703 CRCP 0.42 6.04 0.31 4.11e-9 Calcium levels; LUSC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg06550200 chr5:1325588 CLPTM1L -0.68 -11.74 -0.54 7.31e-27 Lung cancer; LUSC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6690583 1.000 rs6690583 chr1:85466337 A/G cg11262906 chr1:85462892 MCOLN2 -0.71 -8.86 -0.44 4.83e-17 Serum sulfate level; LUSC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg12310025 chr6:25882481 NA -0.72 -12.17 -0.55 1.95e-28 Intelligence (multi-trait analysis); LUSC cis rs9325144 0.555 rs4882284 chr12:38710459 C/T cg13010199 chr12:38710504 ALG10B -0.48 -7.45 -0.38 7.83e-13 Morning vs. evening chronotype; LUSC cis rs9788682 0.747 rs2656074 chr15:78741384 T/C cg06917634 chr15:78832804 PSMA4 0.49 6.05 0.31 3.95e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6840360 0.554 rs62329088 chr4:152471289 C/T cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg12615879 chr12:58013172 SLC26A10 -0.27 -5.66 -0.3 3.22e-8 Multiple sclerosis; LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.9 0.31 9.02e-9 Menopause (age at onset); LUSC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.74 -0.3 2.16e-8 Developmental language disorder (linguistic errors); LUSC cis rs9302635 0.513 rs8050238 chr16:72154187 C/T cg16558253 chr16:72132732 DHX38 -0.41 -5.85 -0.31 1.14e-8 Blood protein levels; LUSC cis rs6840360 0.571 rs4696100 chr4:152514242 C/T cg22705602 chr4:152727874 NA -0.32 -6.54 -0.34 2.28e-10 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.666 rs7124480 chr11:971601 G/A ch.11.42038R chr11:967971 AP2A2 0.41 5.99 0.31 5.3300000000000004e-09 Alzheimer's disease (late onset); LUSC cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg26384229 chr12:38710491 ALG10B 0.94 17.98 0.7 4.92e-51 Heart rate; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06115851 chr18:34408868 C18orf10;KIAA1328 0.41 6.48 0.33 3.38e-10 Asthma; LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg10360139 chr7:1886902 MAD1L1 -0.45 -6.96 -0.36 1.83e-11 Bipolar disorder and schizophrenia; LUSC cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg00484396 chr16:3507460 NAT15 -0.47 -6.99 -0.36 1.48e-11 Body mass index (adult); LUSC cis rs2625529 0.556 rs35603965 chr15:72523043 C/T cg16672083 chr15:72433130 SENP8 0.47 7.86 0.4 5.33e-14 Red blood cell count; LUSC cis rs1865760 0.827 rs9295681 chr6:25944117 T/G cg16482183 chr6:26056742 HIST1H1C 0.47 6.94 0.36 2.02e-11 Height; LUSC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg11752832 chr7:134001865 SLC35B4 0.52 7.99 0.4 2.24e-14 Mean platelet volume; LUSC cis rs72781680 1.000 rs72781680 chr2:24238928 C/T cg08917208 chr2:24149416 ATAD2B 0.99 10.36 0.49 5.38e-22 Lymphocyte counts; LUSC cis rs9311676 0.656 rs9881869 chr3:58333255 G/A cg26110898 chr3:58419937 PDHB -0.43 -6.96 -0.36 1.85e-11 Systemic lupus erythematosus; LUSC cis rs1322639 1.000 rs1322639 chr6:169587103 G/A cg03254818 chr6:169586852 NA -0.44 -6.2 -0.32 1.71e-9 Pulse pressure; LUSC cis rs977987 0.778 rs8057849 chr16:75443816 T/C cg03315344 chr16:75512273 CHST6 0.48 8.98 0.44 2.08e-17 Dupuytren's disease; LUSC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC trans rs7647973 0.626 rs12715437 chr3:49751856 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -6.87 -0.35 3.06e-11 Menarche (age at onset); LUSC cis rs2708977 0.637 rs654224 chr2:97080123 A/C cg01950434 chr2:97203154 ARID5A -0.44 -6.25 -0.32 1.27e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.8 -0.39 7.87e-14 Gut microbiome composition (summer); LUSC cis rs921968 0.541 rs647990 chr2:219441428 T/C cg02176678 chr2:219576539 TTLL4 0.75 14.64 0.63 7.48e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs2303282 0.716 rs2587873 chr16:56412734 C/G cg00500540 chr16:56394104 NA -0.45 -7.67 -0.39 1.96e-13 Breast cancer; LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg10802521 chr3:52805072 NEK4 -0.55 -8.83 -0.44 6.02e-17 Bipolar disorder; LUSC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg02569458 chr12:86230093 RASSF9 0.58 9.93 0.48 1.56e-20 Major depressive disorder; LUSC cis rs7568458 0.709 rs762684 chr2:85782023 G/A cg23752985 chr2:85803571 VAMP8 0.32 6.2 0.32 1.7e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2235649 0.833 rs9933168 chr16:1848361 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.45 -6.25 -0.32 1.27e-9 Blood metabolite levels; LUSC cis rs34779708 0.931 rs2001893 chr10:35300623 G/A cg03585969 chr10:35415529 CREM 0.61 8.94 0.44 2.75e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg27170947 chr2:26402098 FAM59B 0.72 11.04 0.52 2.26e-24 Gut microbiome composition (summer); LUSC cis rs6430585 0.527 rs2254780 chr2:136435526 C/T cg07169764 chr2:136633963 MCM6 0.98 13.27 0.59 1.39e-32 Corneal structure; LUSC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.71 -9.22 -0.45 3.55e-18 Gut microbiome composition (summer); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg13610622 chr10:11504551 USP6NL 0.43 5.96 0.31 6.45e-9 Cognitive function;Information processing speed; LUSC cis rs3824867 1.000 rs3824867 chr11:47468569 A/G cg20307385 chr11:47447363 PSMC3 0.64 9.37 0.46 1.13e-18 Mean corpuscular hemoglobin; LUSC cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs1728785 1.000 rs821167 chr16:68577222 T/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.73 -0.3 2.23e-8 Ulcerative colitis; LUSC cis rs1348850 0.757 rs4893969 chr2:178478476 T/A cg22681709 chr2:178499509 PDE11A -0.57 -10.81 -0.51 1.44e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg23173402 chr1:227635558 NA 0.59 7.23 0.37 3.41e-12 Major depressive disorder; LUSC cis rs7180079 1.000 rs4777181 chr15:64670566 T/C cg02848875 chr15:64387786 SNX1 0.42 5.74 0.3 2.11e-8 Monocyte count; LUSC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg04352962 chr1:209979756 IRF6 -0.54 -6.07 -0.32 3.41e-9 Cleft lip with or without cleft palate; LUSC cis rs7608623 0.773 rs3795946 chr2:23920646 G/C cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC cis rs4786125 0.665 rs1492371 chr16:6921285 A/C cg03623568 chr16:6915990 A2BP1 -0.5 -8.41 -0.42 1.22e-15 Heart rate variability traits (SDNN); LUSC cis rs72960926 0.744 rs114317207 chr6:74955867 C/T cg03266952 chr6:74778945 NA -0.77 -6.84 -0.35 3.73e-11 Metabolite levels (MHPG); LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg11060661 chr22:24314208 DDT;DDTL -0.49 -8.08 -0.4 1.21e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg18252515 chr7:66147081 NA -1.16 -12.82 -0.57 6.95e-31 Diabetic kidney disease; LUSC cis rs62400317 0.859 rs12205523 chr6:45296618 T/C cg18551225 chr6:44695536 NA -0.45 -7.44 -0.38 8.38e-13 Total body bone mineral density; LUSC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC cis rs11025559 0.716 rs1596376 chr11:20454229 T/C cg19653624 chr11:20408972 PRMT3 -0.7 -8.94 -0.44 2.76e-17 Pursuit maintenance gain; LUSC cis rs919433 0.890 rs979020 chr2:198169749 T/C cg10820045 chr2:198174542 NA -0.31 -5.78 -0.3 1.7e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs72781680 0.679 rs718138 chr2:23976324 G/A cg08917208 chr2:24149416 ATAD2B 0.58 6.49 0.33 3.15e-10 Lymphocyte counts; LUSC cis rs1564271 1.000 rs1564271 chr10:27011112 G/A cg13837822 chr10:26931731 LOC731789 0.45 8.91 0.44 3.27e-17 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.68 10.44 0.5 2.84e-22 Lymphocyte counts; LUSC cis rs67981189 0.593 rs7160958 chr14:71442526 C/A cg15816911 chr14:71606274 NA 0.33 5.82 0.3 1.37e-8 Schizophrenia; LUSC cis rs1413885 0.549 rs10889546 chr1:65851759 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.46 6.75 0.35 6.37e-11 Anticoagulant levels; LUSC cis rs2273669 0.667 rs12196010 chr6:109302173 C/A cg05315195 chr6:109294784 ARMC2 -0.56 -6.21 -0.32 1.54e-9 Prostate cancer; LUSC cis rs13006833 0.739 rs172366 chr2:191191233 G/T cg21644426 chr2:191273491 MFSD6 0.44 6.36 0.33 6.81e-10 Urinary metabolites; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17014947 chr15:35529521 LOC723972 0.42 6.28 0.32 1.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4891159 0.548 rs690082 chr18:74116668 C/T cg24786174 chr18:74118243 ZNF516 0.97 21.55 0.76 3.54e-65 Longevity; LUSC cis rs2280018 0.581 rs7404524 chr16:15129158 A/G cg27102117 chr16:15229624 NA 0.58 9.57 0.46 2.44e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg21138405 chr5:131827807 IRF1 0.59 12.19 0.55 1.6e-28 Asthma (sex interaction); LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg19318889 chr4:1322082 MAEA -0.54 -8.87 -0.44 4.63e-17 Obesity-related traits; LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg00814883 chr7:100076585 TSC22D4 -0.66 -7.79 -0.39 8.6e-14 Platelet count; LUSC cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg06784218 chr1:46089804 CCDC17 -0.55 -10.92 -0.51 5.97e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7824557 0.602 rs11784458 chr8:11204184 G/A cg06636001 chr8:8085503 FLJ10661 0.45 6.5 0.34 2.91e-10 Retinal vascular caliber; LUSC cis rs3818285 0.679 rs612155 chr10:111630731 C/G cg00817464 chr10:111662876 XPNPEP1 0.7 12.64 0.57 3.3e-30 Superior crus of antihelix expression; LUSC cis rs4499344 0.526 rs10412141 chr19:33034189 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.76 -10.21 -0.49 1.7e-21 Mean platelet volume; LUSC cis rs1322512 1.000 rs2800623 chr6:153003720 A/G cg27316956 chr6:152958899 SYNE1 0.36 6.19 0.32 1.81e-9 Tonometry; LUSC trans rs61931739 0.517 rs860950 chr12:34104376 C/G cg26384229 chr12:38710491 ALG10B 0.7 10.74 0.51 2.52e-23 Morning vs. evening chronotype; LUSC cis rs7804356 1.000 rs6461980 chr7:26894123 T/G cg03456212 chr7:26904342 SKAP2 -0.52 -6.07 -0.32 3.45e-9 Type 1 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02666073 chr12:110562471 IFT81 0.47 6.27 0.32 1.11e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg11608241 chr8:8085544 FLJ10661 0.47 6.68 0.34 9.87e-11 Neuroticism; LUSC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg14019146 chr3:50243930 SLC38A3 0.31 6.85 0.35 3.58e-11 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.52 0.69 3.21e-49 Chronic sinus infection; LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs752010 0.631 rs1073197 chr1:42059822 C/T cg06885757 chr1:42089581 HIVEP3 -0.58 -11.79 -0.54 4.71e-27 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg22029157 chr1:209979665 IRF6 0.74 8.76 0.43 9.93e-17 Cleft lip with or without cleft palate; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.89 0.35 2.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg24531977 chr5:56204891 C5orf35 -0.69 -10.13 -0.48 3.33e-21 Coronary artery disease; LUSC cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg03477792 chr4:77819574 ANKRD56 0.45 6.1 0.32 2.92e-9 Emphysema distribution in smoking; LUSC cis rs9300255 0.739 rs2337934 chr12:123745359 A/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.21 -0.32 1.59e-9 Neutrophil percentage of white cells; LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg03579872 chr1:53393473 SCP2 0.38 5.64 0.3 3.54e-8 Monocyte count; LUSC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg26441486 chr22:50317300 CRELD2 0.49 7.28 0.37 2.45e-12 Schizophrenia; LUSC cis rs561341 0.629 rs7216107 chr17:30224419 G/A cg13647721 chr17:30228624 UTP6 0.62 8.25 0.41 3.73e-15 Hip circumference adjusted for BMI; LUSC cis rs9549367 0.789 rs2302757 chr13:113909339 A/G cg18105134 chr13:113819100 PROZ -0.69 -9.9 -0.48 2.01e-20 Platelet distribution width; LUSC cis rs965469 1.000 rs6037567 chr20:3332160 C/A cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.3 3.48e-8 IFN-related cytopenia; LUSC cis rs9287719 0.674 rs10929690 chr2:10805974 T/C cg02196655 chr2:10830764 NOL10 0.34 5.79 0.3 1.64e-8 Prostate cancer; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg16606324 chr3:10149918 C3orf24 0.61 8.9 0.44 3.56e-17 Alzheimer's disease; LUSC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.65 0.5 5.52e-23 Homoarginine levels; LUSC cis rs4919087 0.892 rs2065861 chr10:99004608 C/T cg25902810 chr10:99078978 FRAT1 0.47 6.84 0.35 3.73e-11 Monocyte count; LUSC cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg18132916 chr6:79620363 NA -0.37 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs4722404 0.835 rs6965630 chr7:3138656 A/G cg19214707 chr7:3157722 NA -0.32 -5.88 -0.31 1e-8 Atopic dermatitis; LUSC cis rs1538970 0.781 rs12049503 chr1:46021556 G/T cg05343316 chr1:45956843 TESK2 0.7 9.34 0.46 1.39e-18 Platelet count; LUSC cis rs2346177 0.542 rs6757564 chr2:46702619 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.54 -8.51 -0.42 6.13e-16 HDL cholesterol; LUSC cis rs847577 0.715 rs12665986 chr7:97719676 A/G cg24562669 chr7:97807699 LMTK2 -0.37 -6.01 -0.31 4.88e-9 Breast cancer; LUSC trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg21153622 chr11:89784906 NA -0.39 -6.0 -0.31 5.01e-9 HDL cholesterol; LUSC cis rs9372498 0.536 rs62663261 chr6:118900553 T/C cg18833306 chr6:118973337 C6orf204 -0.45 -5.78 -0.3 1.67e-8 Diastolic blood pressure; LUSC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg20573242 chr4:122745356 CCNA2 0.44 6.74 0.35 7e-11 Type 2 diabetes; LUSC cis rs796825 0.530 rs34014378 chr3:119946506 T/A cg21790991 chr3:120137480 FSTL1 -0.33 -5.92 -0.31 7.79e-9 HIV-1 susceptibility; LUSC cis rs9616064 0.557 rs9615397 chr22:47049086 C/T cg25730555 chr22:47059586 GRAMD4 0.45 7.07 0.36 9.34e-12 Urate levels in obese individuals; LUSC cis rs2387326 0.671 rs10829346 chr10:129946104 C/T cg16087940 chr10:129947807 NA -0.4 -6.1 -0.32 2.87e-9 Select biomarker traits; LUSC cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.42e-16 Menopause (age at onset); LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg16325326 chr1:53192061 ZYG11B 0.83 15.05 0.64 1.91e-39 Monocyte count; LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.18 0.45 4.46e-18 Prudent dietary pattern; LUSC cis rs4700695 0.697 rs251319 chr5:65239468 A/G cg21114390 chr5:65439923 SFRS12 0.51 6.06 0.31 3.74e-9 Facial morphology (factor 19); LUSC cis rs9398803 0.932 rs9401876 chr6:126669479 C/A cg19875578 chr6:126661172 C6orf173 0.41 6.12 0.32 2.66e-9 Male-pattern baldness; LUSC cis rs68170813 0.559 rs80212020 chr7:106957596 C/T cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg03929089 chr4:120376271 NA 0.95 15.43 0.65 6.5e-41 Coronary artery disease; LUSC cis rs4363385 0.720 rs11205150 chr1:152959266 C/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.27 -0.37 2.55e-12 Inflammatory skin disease; LUSC cis rs12421382 0.614 rs12420249 chr11:109390254 T/G cg27471124 chr11:109292789 C11orf87 0.37 6.74 0.35 6.99e-11 Schizophrenia; LUSC cis rs6918586 0.658 rs198821 chr6:26123629 T/C cg17691542 chr6:26056736 HIST1H1C 0.39 5.88 0.31 9.87e-9 Schizophrenia; LUSC cis rs4295623 0.553 rs34962960 chr8:11594597 G/A cg21775007 chr8:11205619 TDH -0.49 -7.04 -0.36 1.11e-11 Morning vs. evening chronotype; LUSC cis rs2075671 0.903 rs10953300 chr7:100263784 C/G cg16850897 chr7:100343110 ZAN -0.57 -7.81 -0.39 7.66e-14 Other erythrocyte phenotypes; LUSC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg14664628 chr15:75095509 CSK -0.49 -7.01 -0.36 1.32e-11 Breast cancer; LUSC cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg05347473 chr6:146136440 FBXO30 0.59 10.57 0.5 1.02e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs11792861 0.816 rs3818932 chr9:111664178 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.6 8.85 0.44 5.38e-17 Menarche (age at onset); LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg07332563 chr6:291687 DUSP22 -0.71 -11.82 -0.54 3.71e-27 Menopause (age at onset); LUSC cis rs1150668 0.699 rs1531681 chr6:28226878 A/G cg21251018 chr6:28226885 NKAPL 0.34 6.65 0.34 1.17e-10 Pubertal anthropometrics; LUSC cis rs16866061 1.000 rs7588380 chr2:225341304 A/T cg12698349 chr2:225449008 CUL3 -0.87 -14.59 -0.62 1.21e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg18252515 chr7:66147081 NA -0.53 -7.28 -0.37 2.35e-12 Corneal structure; LUSC cis rs1775715 0.870 rs1419168 chr10:32257332 A/C cg04359828 chr10:32216031 ARHGAP12 0.37 5.98 0.31 5.68e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg01577475 chr2:114033581 PAX8;LOC440839 -0.3 -7.57 -0.38 3.61e-13 Lymphocyte counts; LUSC cis rs9291683 0.595 rs10939665 chr4:10037628 T/C cg11266682 chr4:10021025 SLC2A9 0.57 10.42 0.5 3.29e-22 Bone mineral density; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg25767906 chr1:53392781 SCP2 0.71 14.16 0.61 5.77e-36 Monocyte count; LUSC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.93 -0.44 2.97e-17 Neuroticism; LUSC cis rs2120019 0.567 rs28844983 chr15:75178088 T/A cg17294928 chr15:75287854 SCAMP5 -0.77 -8.86 -0.44 4.7e-17 Blood trace element (Zn levels); LUSC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg03264133 chr6:25882463 NA 0.63 10.68 0.5 4.18e-23 Blood metabolite levels; LUSC cis rs10779751 1.000 rs1205592 chr1:11305663 C/T cg08854313 chr1:11322531 MTOR 0.86 14.14 0.61 6.84e-36 Body mass index; LUSC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg24154853 chr7:158122151 PTPRN2 0.45 8.87 0.44 4.48e-17 Calcium levels; LUSC cis rs7100689 0.646 rs1572819 chr10:82112488 A/G cg00277334 chr10:82204260 NA -0.56 -8.16 -0.41 6.72e-15 Post bronchodilator FEV1; LUSC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg11645453 chr3:52864694 ITIH4 0.32 7.46 0.38 7.53e-13 Bipolar disorder; LUSC trans rs2204008 0.743 rs2127952 chr12:37995364 G/T cg06521331 chr12:34319734 NA -0.4 -6.33 -0.33 7.95e-10 Bladder cancer; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg11905131 chr22:24372483 LOC391322 -0.6 -10.06 -0.48 5.7e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs4727027 0.704 rs2269972 chr7:148914047 C/T cg23158103 chr7:148848205 ZNF398 0.47 7.72 0.39 1.33e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9517320 0.967 rs2274056 chr13:99134839 G/C cg20487152 chr13:99095054 FARP1 0.35 6.54 0.34 2.37e-10 Longevity; LUSC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg20849893 chr7:64541193 NA 0.45 6.41 0.33 4.98e-10 Calcium levels; LUSC cis rs11690935 0.959 rs1113389 chr2:172635365 C/T cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.88 -0.63 9.18e-39 Schizophrenia; LUSC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg24399712 chr22:39784796 NA -0.61 -9.9 -0.48 2.03e-20 Post bronchodilator FEV1; LUSC cis rs61931739 0.517 rs7486246 chr12:34526419 T/G cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg05313129 chr8:58192883 C8orf71 -0.51 -6.64 -0.34 1.26e-10 Developmental language disorder (linguistic errors); LUSC cis rs6121246 0.559 rs6121243 chr20:30415094 C/G cg13852791 chr20:30311386 BCL2L1 0.9 13.63 0.6 6.1e-34 Mean corpuscular hemoglobin; LUSC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23891712 chr17:75136828 SEC14L1 0.73 6.11 0.32 2.75e-9 Cognitive performance; LUSC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg12463550 chr7:65579703 CRCP 0.45 6.62 0.34 1.44e-10 Aortic root size; LUSC cis rs9309473 0.950 rs6740766 chr2:73780913 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.45 -0.33 4.02e-10 Metabolite levels; LUSC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.29e-12 Extrinsic epigenetic age acceleration; LUSC cis rs9916302 0.706 rs9909304 chr17:37500508 G/T cg07936489 chr17:37558343 FBXL20 0.79 9.79 0.47 4.5e-20 Glomerular filtration rate (creatinine); LUSC trans rs11098499 0.866 rs12374352 chr4:120281977 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs6430585 0.583 rs58116536 chr2:136585323 C/T cg07169764 chr2:136633963 MCM6 1.2 18.29 0.71 3.01e-52 Corneal structure; LUSC cis rs6063312 1.000 rs6063313 chr20:47343532 G/A cg18078177 chr20:47281410 PREX1 0.59 6.97 0.36 1.72e-11 Tonometry; LUSC cis rs950169 0.887 rs62029593 chr15:84955180 A/G cg17173187 chr15:85201210 NMB 0.37 6.4 0.33 5.31e-10 Schizophrenia; LUSC cis rs72781680 1.000 rs72788286 chr2:24098321 A/C cg20701182 chr2:24300061 SF3B14 0.56 6.03 0.31 4.36e-9 Lymphocyte counts; LUSC cis rs9640161 0.830 rs35840727 chr7:150063204 A/G cg21361702 chr7:150065534 REPIN1 0.58 8.23 0.41 4.15e-15 Blood protein levels;Circulating chemerin levels; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg09487167 chr14:55518661 MAPK1IP1L 0.4 6.19 0.32 1.8e-9 Schizophrenia; LUSC cis rs9640161 0.783 rs35435439 chr7:150063534 C/T cg10018233 chr7:150070692 REPIN1 0.4 7.18 0.37 4.64e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg13798780 chr7:105162888 PUS7 0.56 5.89 0.31 9.41e-9 Bipolar disorder (body mass index interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01594214 chr6:123110554 SMPDL3A -0.46 -6.05 -0.31 3.81e-9 Bipolar disorder and schizophrenia; LUSC cis rs3772130 0.564 rs28760466 chr3:121601510 A/G cg20356878 chr3:121714668 ILDR1 0.61 9.89 0.48 2.21e-20 Cognitive performance; LUSC cis rs7586879 0.828 rs9631061 chr2:25109804 C/T cg01884057 chr2:25150051 NA 0.41 8.62 0.43 2.67e-16 Body mass index; LUSC cis rs7777754 1.000 rs7778258 chr7:50666378 G/A cg18232548 chr7:50535776 DDC 0.49 6.35 0.33 7.17e-10 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg27124370 chr19:33622961 WDR88 0.53 7.72 0.39 1.34e-13 Bone properties (heel); LUSC trans rs6952808 0.723 rs55689856 chr7:2037215 G/A cg04565464 chr8:145669602 NFKBIL2 0.36 6.01 0.31 4.75e-9 Bipolar disorder and schizophrenia; LUSC trans rs11992162 0.613 rs56094399 chr8:11797470 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.09 -0.32 3.02e-9 Monocyte count; LUSC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.64 0.39 2.28e-13 Vitiligo; LUSC cis rs62400317 0.859 rs12199871 chr6:45307682 C/T cg20913747 chr6:44695427 NA -0.49 -7.89 -0.4 4.31e-14 Total body bone mineral density; LUSC cis rs6967385 0.580 rs6962273 chr7:12330166 G/C cg20607287 chr7:12443886 VWDE 0.37 5.78 0.3 1.72e-8 Response to taxane treatment (placlitaxel); LUSC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7512552 0.809 rs9436112 chr1:150406449 A/C cg15654264 chr1:150340011 RPRD2 0.61 10.04 0.48 6.57e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg15664640 chr17:80829946 TBCD 0.71 12.56 0.57 6.79e-30 Breast cancer; LUSC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.14 -0.32 2.3e-9 Height; LUSC trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg15704280 chr7:45808275 SEPT13 -0.6 -7.34 -0.37 1.68e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg02574844 chr11:5959923 NA -0.4 -6.34 -0.33 7.39e-10 DNA methylation (variation); LUSC cis rs11039100 0.850 rs35746872 chr11:5834335 T/A cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.09 14.64 0.63 7.93e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg19468946 chr17:37922297 IKZF3 -0.43 -6.8 -0.35 4.89e-11 Self-reported allergy; LUSC trans rs877282 0.898 rs11253347 chr10:765769 A/G cg22713356 chr15:30763199 NA 1.07 14.17 0.61 5.24e-36 Uric acid levels; LUSC cis rs360798 0.512 rs2058566 chr2:63179076 C/T cg17519650 chr2:63277830 OTX1 0.51 7.05 0.36 1.01e-11 Coronary artery disease; LUSC cis rs34779708 0.931 rs72789690 chr10:35382817 T/C cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg02428538 chr16:24856791 SLC5A11 0.49 5.68 0.3 2.93e-8 Intelligence (multi-trait analysis); LUSC cis rs2073300 0.609 rs74273791 chr20:23418067 A/T cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.16e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs62400317 0.762 rs12202704 chr6:44819614 G/T cg18551225 chr6:44695536 NA -0.47 -7.51 -0.38 5.4e-13 Total body bone mineral density; LUSC trans rs1459104 0.570 rs56152290 chr11:54858073 C/T cg03929089 chr4:120376271 NA 0.66 6.03 0.31 4.44e-9 Body mass index; LUSC cis rs929354 0.772 rs6954050 chr7:156978554 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg00409905 chr10:38381863 ZNF37A -0.33 -5.86 -0.31 1.11e-8 Extrinsic epigenetic age acceleration; LUSC cis rs3820928 0.692 rs17416354 chr2:227770844 A/G cg11843606 chr2:227700838 RHBDD1 -0.68 -10.8 -0.51 1.58e-23 Pulmonary function; LUSC cis rs6429082 0.749 rs3819974 chr1:235601958 G/T cg26050004 chr1:235667680 B3GALNT2 -0.62 -8.56 -0.42 4.05e-16 Adiposity; LUSC cis rs950169 0.840 rs62029595 chr15:84955301 C/T cg17173187 chr15:85201210 NMB 0.38 6.68 0.34 9.72e-11 Schizophrenia; LUSC trans rs7680126 0.596 rs4698009 chr4:10284993 A/G cg26043149 chr18:55253948 FECH -0.47 -5.98 -0.31 5.64e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; LUSC cis rs7512552 0.839 rs6662108 chr1:150420541 G/T cg15654264 chr1:150340011 RPRD2 0.63 10.53 0.5 1.35e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg03453431 chr7:157225567 NA -0.67 -12.56 -0.57 6.74e-30 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs7681440 0.904 rs6817001 chr4:90766019 C/T cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs12458462 0.892 rs3786228 chr18:77464170 C/T cg11879182 chr18:77439856 CTDP1 -0.73 -12.39 -0.56 2.92e-29 Monocyte count; LUSC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg09699651 chr6:150184138 LRP11 0.39 5.73 0.3 2.28e-8 Lung cancer; LUSC cis rs250677 0.652 rs36042 chr5:148439782 G/T cg18129178 chr5:148520854 ABLIM3 -0.76 -10.52 -0.5 1.54e-22 Breast cancer; LUSC cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg18758796 chr5:131593413 PDLIM4 0.34 5.65 0.3 3.38e-8 Blood metabolite levels; LUSC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg25643088 chr3:52874325 TMEM110 -0.39 -5.87 -0.31 1.05e-8 Schizophrenia; LUSC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg03885332 chr11:832357 CD151 -0.35 -5.9 -0.31 8.82e-9 Mean platelet volume; LUSC trans rs11039798 0.920 rs11040015 chr11:48783130 G/T cg03929089 chr4:120376271 NA 0.7 6.68 0.34 9.95e-11 Axial length; LUSC cis rs7937682 1.000 rs11608122 chr11:111535105 C/T cg22437258 chr11:111473054 SIK2 -0.44 -5.73 -0.3 2.25e-8 Primary sclerosing cholangitis; LUSC cis rs922692 1.000 rs922692 chr15:78984214 C/A cg00540400 chr15:79124168 NA -0.34 -5.68 -0.3 2.88e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg22638593 chr5:131593259 PDLIM4 0.41 6.04 0.31 4.05e-9 Breast cancer; LUSC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00475322 chr7:917719 C7orf20 0.45 6.65 0.34 1.19e-10 Perceived unattractiveness to mosquitoes; LUSC trans rs35110281 0.807 rs28840140 chr21:45039163 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.06 0.48 5.79e-21 Mean corpuscular volume; LUSC cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21986422 chr20:44519582 CTSA;NEURL2 -0.47 -6.28 -0.32 1.04e-9 Bipolar disorder and schizophrenia; LUSC cis rs2996428 0.629 rs12135894 chr1:3728061 C/T cg17848003 chr1:3704513 LRRC47 0.31 5.71 0.3 2.51e-8 Red cell distribution width; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg22903657 chr4:1355424 KIAA1530 -0.48 -8.06 -0.4 1.37e-14 Obesity-related traits; LUSC cis rs6542838 0.641 rs10192266 chr2:99521837 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.43 -5.94 -0.31 7.35e-9 Fear of minor pain; LUSC cis rs2348418 0.715 rs1912782 chr12:28721707 A/C cg13890972 chr12:28721907 NA -0.37 -6.41 -0.33 4.96e-10 Lung function (FVC);Lung function (FEV1); LUSC cis rs892961 0.899 rs72896163 chr17:75412525 C/T cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs4356932 0.934 rs4859603 chr4:76965747 A/G cg00809888 chr4:76862425 NAAA 0.34 5.68 0.3 2.94e-8 Blood protein levels; LUSC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg00933542 chr6:150070202 PCMT1 0.33 6.85 0.35 3.55e-11 Lung cancer; LUSC cis rs6960043 0.764 rs7798124 chr7:15055616 A/G cg19272540 chr7:15055459 NA -0.35 -8.81 -0.43 6.83e-17 Type 2 diabetes; LUSC cis rs4689388 0.926 rs12508672 chr4:6287965 G/A cg14416269 chr4:6271139 WFS1 0.52 10.78 0.51 1.96e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.18 0.49 2.27e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07963361 chr7:87505792 SLC25A40;DBF4 0.4 6.65 0.34 1.21e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2321744 0.573 rs12857276 chr13:34622773 A/C cg27316626 chr8:73450762 KCNB2 0.46 6.03 0.31 4.28e-9 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg18306943 chr3:40428807 ENTPD3 0.38 5.73 0.3 2.2e-8 Renal cell carcinoma; LUSC cis rs2074585 0.806 rs8033813 chr15:90999715 A/T cg03599575 chr15:90893182 GABARAPL3 0.35 6.08 0.32 3.37e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg14552801 chr7:65878734 NA 0.37 5.68 0.3 2.98e-8 Aortic root size; LUSC cis rs10746514 1.000 rs11122416 chr1:232249928 A/G cg09506761 chr1:232265262 NA 0.47 7.63 0.39 2.4e-13 Response to statin therapy; LUSC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs1372520 0.935 rs1442152 chr4:90775649 C/A cg14346243 chr4:90757452 SNCA -0.41 -5.96 -0.31 6.43e-9 Neuroticism; LUSC cis rs12893668 0.703 rs35026580 chr14:104042753 A/G cg08213375 chr14:104286397 PPP1R13B 0.38 6.24 0.32 1.29e-9 Reticulocyte count; LUSC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg25427524 chr10:38739819 LOC399744 -0.74 -14.08 -0.61 1.14e-35 Extrinsic epigenetic age acceleration; LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg02475777 chr4:1388615 CRIPAK 0.38 5.73 0.3 2.23e-8 Obesity-related traits; LUSC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg16797656 chr11:68205561 LRP5 -0.34 -5.76 -0.3 1.88e-8 Total body bone mineral density; LUSC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg00343986 chr7:65444356 GUSB -0.41 -6.2 -0.32 1.62e-9 Aortic root size; LUSC cis rs6546550 0.933 rs57278310 chr2:70093647 T/C cg02498382 chr2:70120550 SNRNP27 -0.29 -7.16 -0.36 5.28e-12 Prevalent atrial fibrillation; LUSC trans rs7980799 0.649 rs12819439 chr12:33684509 A/C cg13010199 chr12:38710504 ALG10B 0.43 6.14 0.32 2.35e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs921968 0.541 rs7601872 chr2:219319885 C/G cg02176678 chr2:219576539 TTLL4 -0.76 -14.28 -0.62 1.92e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11644478 chr21:40555479 PSMG1 0.81 14.78 0.63 2.17e-38 Cognitive function; LUSC cis rs11958404 0.860 rs72818114 chr5:157440207 A/C cg05962755 chr5:157440814 NA 0.53 6.3 0.33 9.34e-10 IgG glycosylation; LUSC cis rs12540874 0.728 rs3807563 chr7:50566390 C/T cg18232548 chr7:50535776 DDC -0.59 -8.38 -0.42 1.51e-15 Systemic sclerosis; LUSC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg19302996 chr17:73780495 UNK -0.49 -7.05 -0.36 1.01e-11 White matter hyperintensity burden; LUSC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg22467129 chr15:76604101 ETFA -0.5 -8.13 -0.41 8.38e-15 Blood metabolite levels; LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.96e-10 Menopause (age at onset); LUSC cis rs1524927 0.643 rs12704882 chr7:96429251 A/C cg03808172 chr7:96339361 SHFM1 0.36 5.65 0.3 3.36e-8 Total body bone mineral density; LUSC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg23625390 chr15:77176239 SCAPER 0.47 7.2 0.37 4.02e-12 Blood metabolite levels; LUSC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg15448220 chr1:150897856 SETDB1 0.43 6.17 0.32 1.94e-9 Melanoma; LUSC cis rs11122272 0.735 rs2486728 chr1:231535883 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.99 -0.48 1.01e-20 Hemoglobin concentration; LUSC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.67 -0.39 1.88e-13 Height; LUSC cis rs231513 0.911 rs231525 chr17:41951283 C/T cg26893861 chr17:41843967 DUSP3 -0.53 -6.11 -0.32 2.8e-9 Cognitive function; LUSC cis rs9815354 1.000 rs6599176 chr3:41788492 G/T cg03022575 chr3:42003672 ULK4 -0.54 -5.82 -0.3 1.38e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg00166722 chr3:10149974 C3orf24 0.39 5.84 0.3 1.24e-8 Alzheimer's disease; LUSC cis rs10746514 0.813 rs9724918 chr1:232248087 C/T cg09506761 chr1:232265262 NA 0.52 8.41 0.42 1.23e-15 Response to statin therapy; LUSC cis rs1670533 1.000 rs935972 chr4:1045171 A/G cg27284194 chr4:1044797 NA 0.55 6.53 0.34 2.47e-10 Recombination rate (females); LUSC trans rs9393777 0.844 rs72839477 chr6:27327000 C/T cg06606381 chr12:133084897 FBRSL1 -0.99 -8.63 -0.43 2.58e-16 Intelligence (multi-trait analysis); LUSC cis rs2573652 0.698 rs12916269 chr15:100530216 A/T cg09918751 chr15:100517450 ADAMTS17 0.35 6.74 0.35 7e-11 Height; LUSC cis rs6503525 0.628 rs62068171 chr17:38103242 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.49 -8.17 -0.41 6.23e-15 Asthma; LUSC cis rs12493885 0.585 rs787814 chr3:153621740 T/A cg17054900 chr3:154042577 DHX36 -0.56 -6.01 -0.31 4.9e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs3960554 0.808 rs61303167 chr7:75671175 G/T cg17325771 chr7:75508891 RHBDD2 -0.41 -5.84 -0.3 1.27e-8 Eotaxin levels; LUSC cis rs73195822 0.614 rs1123852 chr12:111221408 C/G cg12870014 chr12:110450643 ANKRD13A 0.67 7.37 0.37 1.35e-12 Itch intensity from mosquito bite; LUSC cis rs7296418 0.961 rs4275659 chr12:123447928 C/T cg05973401 chr12:123451056 ABCB9 -0.61 -8.81 -0.43 7.14e-17 Platelet count; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24946133 chr1:59249665 JUN -0.45 -5.95 -0.31 6.95e-9 Hepatitis; LUSC cis rs829883 0.659 rs10860342 chr12:98941223 C/T cg25150519 chr12:98850993 NA 0.63 8.28 0.41 3.01e-15 Colorectal adenoma (advanced); LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg16325326 chr1:53192061 ZYG11B 0.7 11.39 0.53 1.33e-25 Monocyte count; LUSC cis rs4595586 0.545 rs11610886 chr12:39390613 C/G cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC trans rs9329221 0.510 rs4841282 chr8:9975604 C/A cg15556689 chr8:8085844 FLJ10661 0.53 7.96 0.4 2.79e-14 Neuroticism; LUSC cis rs7043114 0.525 rs710162 chr9:95059790 A/T cg13798575 chr9:95087839 CENPP;NOL8 0.37 6.56 0.34 2.09e-10 Height; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg08888203 chr3:10149979 C3orf24 0.63 8.66 0.43 2.01e-16 Alzheimer's disease; LUSC cis rs9462027 0.628 rs2477507 chr6:34703599 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.31 -5.65 -0.3 3.46e-8 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.5e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 1.000 rs1448094 chr12:86343135 G/T cg00310523 chr12:86230176 RASSF9 0.39 7.11 0.36 7.01e-12 Major depressive disorder; LUSC cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -6.41 -0.33 4.91e-10 Red blood cell count;Reticulocyte count; LUSC trans rs4729127 1.000 rs17166205 chr7:94003841 T/A cg14660007 chr13:78271894 SLAIN1 0.49 6.22 0.32 1.52e-9 Intelligence; LUSC trans rs7819412 0.521 rs9329238 chr8:11033737 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.13 -0.36 6.2e-12 Triglycerides; LUSC cis rs240764 0.658 rs1336244 chr6:101197953 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg03579872 chr1:53393473 SCP2 -0.39 -5.78 -0.3 1.74e-8 Monocyte count; LUSC cis rs7586879 0.929 rs6545808 chr2:25124388 C/A cg15423357 chr2:25149977 NA 0.35 6.36 0.33 6.54e-10 Body mass index; LUSC cis rs10779751 0.960 rs11121712 chr1:11320329 G/C cg08854313 chr1:11322531 MTOR 0.92 16.17 0.66 7.91e-44 Body mass index; LUSC cis rs5769707 0.681 rs8140095 chr22:50043795 A/G cg20744362 chr22:50050164 C22orf34 0.4 7.32 0.37 1.9e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg20135002 chr11:47629003 NA -0.52 -8.15 -0.41 7.62e-15 Subjective well-being; LUSC cis rs10207628 0.698 rs7594230 chr2:127873568 G/A cg06223080 chr2:127868745 NA 0.38 6.51 0.34 2.8e-10 Psychosis and Alzheimer's disease; LUSC cis rs240764 0.817 rs2036052 chr6:101154909 G/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.25 -0.32 1.22e-9 Neuroticism; LUSC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg01420254 chr6:26195488 NA 0.64 7.05 0.36 1.04e-11 Gout;Renal underexcretion gout; LUSC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg06026331 chr20:60912101 LAMA5 -0.63 -7.54 -0.38 4.39e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs950169 0.881 rs4081123 chr15:84956235 A/G cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.64e-15 Schizophrenia; LUSC cis rs10911232 0.507 rs4651137 chr1:182994300 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.05 0.52 2.14e-24 Hypertriglyceridemia; LUSC cis rs7072216 0.763 rs2274244 chr10:100175218 A/G cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg18350739 chr11:68623251 NA -0.38 -6.74 -0.35 7.09e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7829975 0.567 rs6601273 chr8:8796519 T/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.85 -0.35 3.46e-11 Mood instability; LUSC cis rs9419702 0.538 rs9419628 chr10:133539299 A/C cg04492858 chr10:133558786 NA 0.41 6.64 0.34 1.28e-10 Survival in rectal cancer; LUSC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg06740227 chr12:86229804 RASSF9 -0.36 -5.88 -0.31 9.93e-9 Major depressive disorder; LUSC cis rs7107174 1.000 rs2244508 chr11:77948515 T/A cg02023728 chr11:77925099 USP35 0.43 6.22 0.32 1.46e-9 Testicular germ cell tumor; LUSC cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg02527881 chr3:46936655 PTH1R 0.66 11.92 0.55 1.54e-27 Birth weight; LUSC cis rs881375 0.967 rs2109895 chr9:123677827 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.93 0.35 2.18e-11 Rheumatoid arthritis; LUSC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg12564285 chr5:131593104 PDLIM4 0.43 7.94 0.4 3.08e-14 Breast cancer; LUSC cis rs10876993 0.890 rs10783844 chr12:58098425 A/C cg18357645 chr12:58087776 OS9 0.6 9.02 0.44 1.51e-17 Celiac disease or Rheumatoid arthritis; LUSC cis rs9902453 1.000 rs59274738 chr17:28437635 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.38 0.42 1.49e-15 Coffee consumption (cups per day); LUSC trans rs2018683 0.649 rs221193 chr7:29015784 G/T cg19402173 chr7:128379420 CALU -0.43 -6.42 -0.33 4.67e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs6496667 0.533 rs2074583 chr15:91009192 T/C cg10434728 chr15:90938212 IQGAP1 0.31 5.97 0.31 6.02e-9 Rheumatoid arthritis; LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.1 0.41 1.05e-14 Prudent dietary pattern; LUSC cis rs10871290 0.881 rs11649338 chr16:74471420 C/T cg01733217 chr16:74700730 RFWD3 -0.52 -7.53 -0.38 4.91e-13 Breast cancer; LUSC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6500602 0.893 rs934888 chr16:4462832 C/T cg08645402 chr16:4508243 NA 0.51 7.72 0.39 1.33e-13 Schizophrenia; LUSC cis rs10197940 0.662 rs13555 chr2:152333304 C/A cg06191203 chr2:152266755 RIF1 -0.53 -7.3 -0.37 2.17e-12 Lung cancer; LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg00149659 chr3:10157352 C3orf10 1.0 14.48 0.62 3.22e-37 Alzheimer's disease; LUSC cis rs734999 0.588 rs3001837 chr1:2532506 G/A cg18932078 chr1:2524107 MMEL1 -0.33 -7.17 -0.37 4.74e-12 Ulcerative colitis; LUSC cis rs11098499 0.754 rs2036856 chr4:120249288 G/A cg24375607 chr4:120327624 NA 0.76 12.2 0.56 1.45e-28 Corneal astigmatism; LUSC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg06873352 chr17:61820015 STRADA 0.56 8.62 0.43 2.81e-16 Height; LUSC trans rs1493916 0.967 rs9953768 chr18:31399468 A/G cg13755796 chr4:20253514 NA -0.43 -6.6 -0.34 1.59e-10 Life satisfaction; LUSC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg13319975 chr6:146136371 FBXO30 0.51 7.55 0.38 4.09e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs11958404 0.932 rs59246968 chr5:157418180 T/C cg05962755 chr5:157440814 NA 0.5 6.14 0.32 2.34e-9 IgG glycosylation; LUSC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.83 0.35 4.1e-11 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.8 -0.3 1.5e-8 Crohn's disease; LUSC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg05368731 chr17:41323189 NBR1 0.92 15.52 0.65 2.79e-41 Menopause (age at onset); LUSC cis rs2075371 0.501 rs1646654 chr7:134027547 G/C cg11752832 chr7:134001865 SLC35B4 0.4 5.79 0.3 1.65e-8 Mean platelet volume; LUSC cis rs9653442 0.545 rs11900482 chr2:100758709 G/C cg07810366 chr2:100720526 AFF3 -0.45 -7.68 -0.39 1.82e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg16414030 chr3:133502952 NA 0.46 7.14 0.36 5.92e-12 Iron status biomarkers; LUSC cis rs11997175 0.766 rs7387133 chr8:33727045 C/G ch.8.33884649F chr8:33765107 NA -0.4 -6.26 -0.32 1.19e-9 Body mass index; LUSC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg03806693 chr22:41940476 POLR3H -1.03 -13.99 -0.61 2.43e-35 Crohn's disease;Inflammatory bowel disease; LUSC cis rs3820928 0.874 rs12467261 chr2:227888838 T/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.83 -0.39 6.56e-14 Pulmonary function; LUSC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg07959070 chr22:50026188 C22orf34 -0.34 -6.93 -0.35 2.19e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8063761 0.589 rs4238833 chr16:90050689 G/T cg12064134 chr16:90016061 DEF8 0.38 6.05 0.31 3.84e-9 Squamous cell carcinoma; LUSC cis rs7712401 0.601 rs27976 chr5:122206460 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.89 -0.48 2.12e-20 Mean platelet volume; LUSC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg04414720 chr1:150670196 GOLPH3L 0.53 8.23 0.41 4.4e-15 Melanoma; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs3020736 0.500 rs2413669 chr22:42507748 A/C cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7247513 0.701 rs8107642 chr19:12766370 C/T cg01871581 chr19:12707946 ZNF490 -0.56 -8.99 -0.44 1.82e-17 Bipolar disorder; LUSC cis rs7615316 0.934 rs9808943 chr3:142241123 T/C cg16271453 chr3:142027066 XRN1 -0.39 -6.82 -0.35 4.3e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs11098499 0.863 rs58452170 chr4:120459674 A/T cg25214090 chr10:38739885 LOC399744 0.53 7.68 0.39 1.76e-13 Corneal astigmatism; LUSC trans rs2055729 0.645 rs12056944 chr8:9742525 C/G cg06636001 chr8:8085503 FLJ10661 0.54 6.7 0.34 8.86e-11 Multiple myeloma (hyperdiploidy); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25552655 chr19:33864476 CEBPG -0.45 -6.75 -0.35 6.74e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4332037 0.707 rs4721096 chr7:1877311 T/C cg11693508 chr17:37793320 STARD3 -0.49 -6.0 -0.31 5.15e-9 Bipolar disorder; LUSC cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.63 -0.39 2.47e-13 Personality dimensions; LUSC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg25456477 chr12:86230367 RASSF9 0.35 6.21 0.32 1.56e-9 Major depressive disorder; LUSC cis rs1113500 0.933 rs11185255 chr1:108633191 T/A cg11967332 chr1:108735228 SLC25A24 0.39 5.92 0.31 7.86e-9 Growth-regulated protein alpha levels; LUSC cis rs4363385 0.574 rs4845505 chr1:152960943 T/A cg25856811 chr1:152973957 SPRR3 -0.36 -6.01 -0.31 4.84e-9 Inflammatory skin disease; LUSC cis rs11030122 0.702 rs4910868 chr11:3980224 A/C cg08557956 chr11:4115526 RRM1 -0.46 -5.72 -0.3 2.39e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg12463550 chr7:65579703 CRCP 0.51 7.52 0.38 5.19e-13 Aortic root size; LUSC trans rs9329221 0.710 rs11785061 chr8:10259528 G/C cg06636001 chr8:8085503 FLJ10661 0.51 6.91 0.35 2.41e-11 Neuroticism; LUSC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.4 6.26 0.32 1.2e-9 Total body bone mineral density; LUSC cis rs4595586 0.545 rs61939643 chr12:39378460 G/A cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs7954584 0.505 rs11043278 chr12:122412145 C/T cg10207240 chr12:122356781 WDR66 0.45 6.24 0.32 1.31e-9 Mean corpuscular volume; LUSC cis rs6546550 0.694 rs12467361 chr2:70019127 G/A cg02498382 chr2:70120550 SNRNP27 -0.27 -6.5 -0.34 2.87e-10 Prevalent atrial fibrillation; LUSC cis rs1801251 1.000 rs6714245 chr2:233580505 T/C cg25237894 chr2:233734115 C2orf82 0.35 6.41 0.33 4.94e-10 Coronary artery disease; LUSC cis rs11166629 1.000 rs7818331 chr8:135639653 C/T cg27224718 chr8:135614730 ZFAT 0.66 11.21 0.52 5.49e-25 Smoking quantity; LUSC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg22875332 chr1:76189707 ACADM -0.85 -14.0 -0.61 2.22e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9865818 0.728 rs1915930 chr3:188100256 G/T cg23651889 chr3:188115336 LPP -0.37 -5.65 -0.3 3.36e-8 Allergic sensitization; LUSC trans rs61931739 0.500 rs28624237 chr12:34457171 G/T cg13010199 chr12:38710504 ALG10B 0.68 10.81 0.51 1.49e-23 Morning vs. evening chronotype; LUSC trans rs853679 0.607 rs36101351 chr6:27943369 C/T cg06606381 chr12:133084897 FBRSL1 -0.95 -8.54 -0.42 4.88e-16 Depression; LUSC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg09365446 chr1:150670422 GOLPH3L 0.47 6.74 0.35 6.85e-11 Melanoma; LUSC cis rs478304 0.934 rs669742 chr11:65501291 C/T cg08755490 chr11:65554678 OVOL1 0.4 5.84 0.3 1.24e-8 Acne (severe); LUSC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg04398451 chr17:18023971 MYO15A 0.5 7.97 0.4 2.45e-14 Total body bone mineral density; LUSC cis rs7215564 0.908 rs57778244 chr17:78653798 T/G cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs16949788 1.000 rs79097157 chr15:66764814 C/A cg08120210 chr15:66682733 MAP2K1 -0.63 -6.48 -0.33 3.32e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs17490626 0.568 rs12416520 chr10:71211945 A/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.43 -0.46 7e-19 Thrombosis; LUSC cis rs11190604 1.000 rs7099913 chr10:102314777 T/C cg16342193 chr10:102329863 NA -0.34 -6.05 -0.31 3.87e-9 Palmitoleic acid (16:1n-7) levels; LUSC trans rs2262909 1.000 rs2175366 chr19:22128279 C/T cg17074339 chr11:11642133 GALNTL4 -0.41 -6.19 -0.32 1.8e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9393777 0.622 rs13191326 chr6:27031029 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.48 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs7914558 0.966 rs12766205 chr10:104893568 A/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.05 -0.36 1.05e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1451375 0.652 rs1470747 chr7:50627009 C/T cg18232548 chr7:50535776 DDC 0.48 6.62 0.34 1.43e-10 Malaria; LUSC cis rs10782582 0.593 rs115291524 chr1:76141811 A/G cg22875332 chr1:76189707 ACADM -0.4 -5.92 -0.31 8.19e-9 Daytime sleep phenotypes; LUSC cis rs11608355 0.846 rs12581637 chr12:109855429 G/A cg05360138 chr12:110035743 NA 0.6 8.03 0.4 1.73e-14 Neuroticism; LUSC cis rs62064224 0.589 rs9910731 chr17:30784034 A/G cg18200150 chr17:30822561 MYO1D 0.3 5.86 0.31 1.11e-8 Schizophrenia; LUSC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.64 0.34 1.29e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13256369 0.802 rs13256404 chr8:8562974 T/C cg17143192 chr8:8559678 CLDN23 0.64 9.02 0.44 1.47e-17 Obesity-related traits; LUSC cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg03264133 chr6:25882463 NA -0.34 -5.71 -0.3 2.44e-8 Height; LUSC cis rs4363385 0.693 rs6690672 chr1:152930564 C/T cg07796016 chr1:152779584 LCE1C -0.45 -6.4 -0.33 5.25e-10 Inflammatory skin disease; LUSC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg20503657 chr10:835505 NA 1.21 16.13 0.66 1.08e-43 Eosinophil percentage of granulocytes; LUSC cis rs11690935 0.877 rs72890834 chr2:172835802 G/T cg13550731 chr2:172543902 DYNC1I2 -0.87 -14.18 -0.61 4.69e-36 Schizophrenia; LUSC cis rs1790761 0.658 rs666328 chr11:67335538 G/A cg23188684 chr11:67383651 NA 0.35 6.19 0.32 1.76e-9 Mean corpuscular volume; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg11905131 chr22:24372483 LOC391322 -0.52 -8.7 -0.43 1.53e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs354225 0.544 rs10187447 chr2:54806711 A/T cg26097391 chr2:54893211 SPTBN1 0.42 6.39 0.33 5.6e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.82 0.35 4.17e-11 Platelet count; LUSC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs936229 0.861 rs12441505 chr15:75107311 A/C cg14664628 chr15:75095509 CSK -1.01 -18.16 -0.7 9.36e-52 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs9784649 1.000 rs56205870 chr5:24958870 A/G cg08600765 chr20:34638493 LOC647979 -0.56 -6.2 -0.32 1.64e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs61931739 0.534 rs11053005 chr12:34091626 A/C cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg02380750 chr20:61661411 NA 0.34 5.96 0.31 6.5e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs231513 0.954 rs425135 chr17:41984517 A/C cg10566589 chr6:111927040 TRAF3IP2 0.53 6.05 0.31 3.97e-9 Cognitive function; LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs8114671 0.562 rs6058137 chr20:33475074 G/A cg07148914 chr20:33460835 GGT7 0.56 8.56 0.42 4.04e-16 Height; LUSC cis rs11711311 1.000 rs9863050 chr3:113508888 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.79 -0.3 1.62e-8 IgG glycosylation; LUSC cis rs9326248 0.581 rs12804122 chr11:116902616 C/G cg01368799 chr11:117014884 PAFAH1B2 0.61 9.46 0.46 5.81e-19 Blood protein levels; LUSC trans rs11039798 0.764 rs11040208 chr11:49012509 A/G cg03929089 chr4:120376271 NA 0.77 6.33 0.33 8.04e-10 Axial length; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg19318889 chr4:1322082 MAEA -0.54 -8.8 -0.43 7.35e-17 Obesity-related traits; LUSC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.35 5.89 0.31 9.36e-9 Menopause (age at onset); LUSC cis rs6665290 0.904 rs1186 chr1:227177731 A/T cg10327440 chr1:227177885 CDC42BPA -1.21 -40.51 -0.91 6.17e-131 Myeloid white cell count; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg00166722 chr3:10149974 C3orf24 0.59 8.25 0.41 3.57e-15 Alzheimer's disease; LUSC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg00791764 chr4:53727839 RASL11B 0.56 7.79 0.39 8.62e-14 Optic nerve measurement (cup area); LUSC cis rs10751667 1.000 rs7394449 chr11:962190 T/C ch.11.42038R chr11:967971 AP2A2 0.54 8.37 0.42 1.56e-15 Alzheimer's disease (late onset); LUSC cis rs6121246 0.567 rs6060262 chr20:30193071 A/C cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.2e-10 Mean corpuscular hemoglobin; LUSC cis rs10484885 0.824 rs72919981 chr6:90528977 T/C cg13799429 chr6:90582589 CASP8AP2 -0.83 -7.74 -0.39 1.19e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs826838 0.967 rs826870 chr12:39120250 G/A cg13010199 chr12:38710504 ALG10B -0.64 -10.96 -0.51 4.43e-24 Heart rate; LUSC cis rs1153858 1.000 rs2467863 chr15:45641880 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.54 0.5 1.29e-22 Homoarginine levels; LUSC cis rs1375194 0.606 rs10188817 chr2:33815471 A/G cg04131969 chr2:33951647 MYADML -0.64 -8.95 -0.44 2.47e-17 Response to antidepressants in depression; LUSC cis rs6120849 0.617 rs12480442 chr20:33648388 C/G cg24642439 chr20:33292090 TP53INP2 0.61 6.71 0.34 8.49e-11 Protein C levels; LUSC cis rs4363385 0.818 rs2339492 chr1:152985552 G/C cg00922841 chr1:152955080 SPRR1A -0.42 -7.16 -0.36 5.23e-12 Inflammatory skin disease; LUSC cis rs9650657 0.537 rs11250092 chr8:10786543 A/G cg21775007 chr8:11205619 TDH 0.47 6.66 0.34 1.12e-10 Neuroticism; LUSC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC trans rs804280 0.509 rs13276433 chr8:11783036 A/G cg14343924 chr8:8086146 FLJ10661 0.44 6.23 0.32 1.41e-9 Myopia (pathological); LUSC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.61 0.62 1.05e-37 Allergic disease (asthma, hay fever or eczema); LUSC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg11764359 chr7:65958608 NA -0.69 -10.44 -0.5 2.96e-22 Aortic root size; LUSC cis rs644799 0.610 rs1255179 chr11:95472097 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.59 9.13 0.45 6.77e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC cis rs11098499 0.779 rs7674500 chr4:120303593 C/T cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs8017423 0.647 rs12883000 chr14:90820557 G/A cg04374321 chr14:90722782 PSMC1 -0.44 -6.63 -0.34 1.34e-10 Mortality in heart failure; LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.99 -0.31 5.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg05425664 chr17:57184151 TRIM37 0.62 9.67 0.47 1.14e-19 Intelligence (multi-trait analysis); LUSC cis rs12291225 0.535 rs10832248 chr11:14413087 G/A cg05501817 chr11:14380813 RRAS2 -0.46 -7.29 -0.37 2.28e-12 Sense of smell; LUSC cis rs10464366 0.843 rs12701691 chr7:39090177 T/G cg18850127 chr7:39170497 POU6F2 0.42 5.95 0.31 6.81e-9 IgG glycosylation; LUSC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg12311346 chr5:56204834 C5orf35 -0.6 -9.29 -0.45 2.02e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg21361702 chr7:150065534 REPIN1 0.46 5.87 0.31 1.04e-8 Blood protein levels;Circulating chemerin levels; LUSC trans rs12310956 0.532 rs35366144 chr12:33992000 C/G cg26384229 chr12:38710491 ALG10B 0.75 11.76 0.54 5.82e-27 Morning vs. evening chronotype; LUSC cis rs58749629 1.000 rs3827066 chr20:44586023 C/T cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.54 -6.04 -0.31 4.2e-9 Abdominal aortic aneurysm; LUSC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg04317338 chr11:64019027 PLCB3 0.71 8.02 0.4 1.76e-14 Mean platelet volume; LUSC cis rs1355223 0.506 rs1828299 chr11:34870418 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.76 -0.35 6.01e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg06618935 chr21:46677482 NA -0.4 -8.06 -0.4 1.41e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs11676348 0.772 rs11687200 chr2:218944615 A/G cg00012203 chr2:219082015 ARPC2 -0.5 -7.72 -0.39 1.4e-13 Ulcerative colitis; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.45 0.5 2.69e-22 Alzheimer's disease; LUSC trans rs7829975 0.624 rs7823056 chr8:8382705 A/G cg27411982 chr8:10470053 RP1L1 0.43 7.13 0.36 6.28e-12 Mood instability; LUSC cis rs9399135 0.967 rs11754783 chr6:135347661 T/A cg24558204 chr6:135376177 HBS1L 0.59 9.28 0.45 2.26e-18 Red blood cell count; LUSC cis rs72772090 0.908 rs72772091 chr5:96040122 C/A cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -7.44 -0.38 8.8e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4363385 0.626 rs12062770 chr1:153062837 A/C cg00922841 chr1:152955080 SPRR1A -0.35 -5.99 -0.31 5.32e-9 Inflammatory skin disease; LUSC trans rs9329221 0.527 rs34259385 chr8:10325456 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.21 -0.37 3.82e-12 Neuroticism; LUSC cis rs75804782 0.581 rs13415491 chr2:239319901 C/T cg18131467 chr2:239335373 ASB1 -0.74 -6.64 -0.34 1.28e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg22166914 chr1:53195759 ZYG11B -0.69 -12.08 -0.55 4.17e-28 Monocyte count; LUSC cis rs7072216 0.727 rs7901577 chr10:100164442 A/G cg26618903 chr10:100175079 PYROXD2 -0.46 -8.44 -0.42 1e-15 Metabolite levels; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.39 -6.28 -0.32 1.07e-9 Longevity;Endometriosis; LUSC cis rs3820928 0.874 rs10169717 chr2:227796911 T/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.38e-13 Pulmonary function; LUSC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg02187348 chr16:89574699 SPG7 0.57 9.24 0.45 2.86e-18 Multiple myeloma (IgH translocation); LUSC cis rs9814567 0.806 rs9839705 chr3:134323819 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.31 -0.56 5.64e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs61863818 0.842 rs11189214 chr10:99181008 A/G cg08345082 chr10:99160200 RRP12 0.34 6.12 0.32 2.58e-9 Monocyte percentage of white cells; LUSC cis rs926938 0.618 rs516985 chr1:115495011 G/A cg12756093 chr1:115239321 AMPD1 0.48 7.26 0.37 2.78e-12 Autism; LUSC cis rs67696533 0.957 rs293567 chr20:31098565 A/C cg13636640 chr20:31349939 DNMT3B -0.42 -6.2 -0.32 1.62e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs17095355 0.818 rs72828263 chr10:111785703 G/A cg00817464 chr10:111662876 XPNPEP1 -0.58 -6.72 -0.34 8.01e-11 Biliary atresia; LUSC cis rs11122272 0.735 rs2739518 chr1:231537633 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.03 0.48 6.95e-21 Hemoglobin concentration; LUSC trans rs62238980 0.614 rs4821016 chr22:32402598 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs208520 0.690 rs1885100 chr6:66871047 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.96 -0.68 5.59e-47 Exhaled nitric oxide output; LUSC cis rs78663649 0.908 rs79083128 chr19:16556222 G/C cg05286348 chr19:16641544 CHERP -0.61 -5.85 -0.3 1.16e-8 White blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01719123 chr8:28244050 ZNF395 0.44 6.56 0.34 2.03e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs477692 0.699 rs557311 chr10:131389484 A/G cg26102564 chr10:131424627 MGMT 0.4 6.1 0.32 2.94e-9 Response to temozolomide; LUSC cis rs78707713 0.560 rs17569412 chr10:71237536 C/A cg12610070 chr10:71211762 TSPAN15 -0.49 -9.6 -0.47 1.96e-19 Venous thromboembolism; LUSC cis rs4660306 0.961 rs4660868 chr1:45986497 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.53 -0.34 2.48e-10 Homocysteine levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27488370 chr7:128046294 IMPDH1 0.38 6.01 0.31 4.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg22618164 chr12:122356400 WDR66 -0.61 -9.36 -0.46 1.21e-18 Mean corpuscular volume; LUSC cis rs225245 0.817 rs2301730 chr17:33998683 A/G cg05299278 chr17:33885742 SLFN14 0.29 6.35 0.33 7.12e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs2727020 0.553 rs4103567 chr11:49255389 C/T cg15704280 chr7:45808275 SEPT13 -0.7 -10.33 -0.49 6.71e-22 Coronary artery disease; LUSC cis rs1784581 0.674 rs1789990 chr6:162406957 G/T cg17173639 chr6:162384350 PARK2 -0.63 -11.62 -0.54 1.96e-26 Itch intensity from mosquito bite; LUSC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg27572855 chr1:25598939 RHD 0.41 7.29 0.37 2.26e-12 Erythrocyte sedimentation rate; LUSC trans rs2243480 1.000 rs9769882 chr7:65642925 T/C cg10756647 chr7:56101905 PSPH -0.84 -8.42 -0.42 1.14e-15 Diabetic kidney disease; LUSC cis rs6460942 0.915 rs72584550 chr7:12304990 G/A cg06484146 chr7:12443880 VWDE -0.52 -6.31 -0.33 9.12e-10 Coronary artery disease; LUSC cis rs9653442 0.564 rs12992234 chr2:100767886 G/A cg22139774 chr2:100720529 AFF3 -0.42 -7.07 -0.36 9.09e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1211375 0.607 rs1203978 chr16:257211 A/C cg00126636 chr16:237282 NA 0.42 6.58 0.34 1.82e-10 Hematology traits;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8038465 0.622 rs710086 chr15:73877001 C/T cg15420318 chr15:73925796 NPTN 0.57 9.55 0.46 2.99e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6964587 1.000 rs35317449 chr7:91637010 G/A cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.71e-18 Breast cancer; LUSC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg22467129 chr15:76604101 ETFA -0.43 -6.89 -0.35 2.73e-11 Blood metabolite levels; LUSC cis rs6722750 0.933 rs4671555 chr2:64411137 C/G cg22352474 chr2:64371530 PELI1 -0.52 -7.76 -0.39 1.06e-13 Neuroticism; LUSC cis rs6840360 0.532 rs4235221 chr4:152511193 C/T cg22705602 chr4:152727874 NA -0.33 -6.61 -0.34 1.53e-10 Intelligence (multi-trait analysis); LUSC trans rs6952808 1.000 rs6957894 chr7:1887362 G/A cg24247370 chr13:99142703 STK24 -0.35 -6.49 -0.33 3.15e-10 Bipolar disorder and schizophrenia; LUSC cis rs4595586 0.545 rs3858553 chr12:39381291 A/C cg13010199 chr12:38710504 ALG10B 0.43 6.07 0.32 3.39e-9 Morning vs. evening chronotype; LUSC cis rs4268898 0.722 rs35520052 chr2:24415277 C/T cg06627628 chr2:24431161 ITSN2 0.61 8.88 0.44 4.24e-17 Asthma; LUSC cis rs9921338 0.961 rs77552156 chr16:11426399 C/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.66 -0.34 1.14e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1023500 0.596 rs133352 chr22:42434022 C/A cg05082376 chr22:42548792 NA -0.39 -5.85 -0.3 1.17e-8 Schizophrenia; LUSC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.59 0.5 8.56e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7582180 0.629 rs7597615 chr2:100954828 T/C cg12002119 chr2:101014098 CHST10 0.35 5.65 0.3 3.35e-8 Intelligence (multi-trait analysis); LUSC cis rs1005224 0.853 rs12898082 chr14:76306359 A/C cg04684003 chr14:76127793 TTLL5;C14orf1 0.56 7.78 0.39 9.29e-14 Large artery stroke; LUSC trans rs61931739 0.500 rs35030191 chr12:34548865 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg13393036 chr8:95962371 TP53INP1 0.42 8.84 0.44 5.71e-17 Type 2 diabetes; LUSC cis rs9788682 0.792 rs35031105 chr15:78772806 C/T cg06917634 chr15:78832804 PSMA4 -0.49 -5.99 -0.31 5.54e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs3784262 0.904 rs17820823 chr15:58239358 A/G cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.78 -0.3 1.74e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs8017423 0.791 rs7146250 chr14:90711703 A/G cg14092571 chr14:90743983 NA -0.37 -5.98 -0.31 5.8e-9 Mortality in heart failure; LUSC cis rs739401 0.611 rs450817 chr11:3056712 A/G cg25174290 chr11:3078921 CARS 0.58 9.3 0.45 1.91e-18 Longevity; LUSC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg22166914 chr1:53195759 ZYG11B -0.55 -8.78 -0.43 8.88e-17 Monocyte count; LUSC cis rs9399135 0.967 rs3756799 chr6:135341011 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.0 0.44 1.77e-17 Red blood cell count; LUSC cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg03146154 chr1:46216737 IPP 0.53 8.04 0.4 1.55e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11039100 0.765 rs72896130 chr11:5834405 C/T cg13902645 chr11:5959945 NA -0.53 -5.86 -0.31 1.09e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg23758822 chr17:41437982 NA 1.03 20.39 0.74 1.38e-60 Menopause (age at onset); LUSC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08704250 chr15:31115839 NA -0.47 -7.03 -0.36 1.17e-11 Huntington's disease progression; LUSC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs7647973 0.626 rs6809879 chr3:49834571 A/G cg13072238 chr3:49761600 GMPPB 0.68 8.72 0.43 1.32e-16 Menarche (age at onset); LUSC cis rs459571 0.629 rs441233 chr9:136876021 A/G cg14462750 chr9:136913113 BRD3 -0.36 -5.69 -0.3 2.72e-8 Platelet distribution width; LUSC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg09491104 chr22:46646882 C22orf40 -0.67 -7.09 -0.36 8.06e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg06238570 chr21:40685208 BRWD1 -0.62 -10.42 -0.5 3.42e-22 Cognitive function; LUSC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg05347473 chr6:146136440 FBXO30 0.66 11.61 0.54 2.02e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg20608306 chr11:116969690 SIK3 0.36 6.79 0.35 5.04e-11 Blood protein levels; LUSC cis rs11098499 0.863 rs3775858 chr4:120486028 A/G cg24375607 chr4:120327624 NA 0.74 10.89 0.51 7.53e-24 Corneal astigmatism; LUSC cis rs79911532 0.515 rs79859948 chr7:75679099 A/G cg03592824 chr7:75666768 STYXL1 0.7 6.84 0.35 3.84e-11 Mononucleosis; LUSC cis rs2820315 1.000 rs2250377 chr1:201860626 A/G cg10061532 chr1:201886748 LMOD1 -0.27 -5.96 -0.31 6.42e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg10253484 chr15:75165896 SCAMP2 -0.47 -6.61 -0.34 1.52e-10 Breast cancer; LUSC cis rs2731664 0.792 rs163199 chr5:176890067 A/G cg23176889 chr5:176863531 GRK6 -0.68 -14.3 -0.62 1.62e-36 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg13798780 chr7:105162888 PUS7 0.58 6.15 0.32 2.21e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg20887711 chr4:1340912 KIAA1530 -0.49 -7.34 -0.37 1.65e-12 Obesity-related traits; LUSC trans rs7739264 0.602 rs1121384 chr6:19771507 A/G cg16463452 chr13:29195249 NA 0.3 6.04 0.31 4.09e-9 Endometriosis; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg07724433 chr4:147443257 SLC10A7 0.49 6.32 0.33 8.43e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg20503657 chr10:835505 NA 0.97 13.49 0.59 2.05e-33 Eosinophil percentage of granulocytes; LUSC cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.96e-12 Motion sickness; LUSC cis rs7809950 1.000 rs4727681 chr7:107096144 T/C cg23024343 chr7:107201750 COG5 -0.54 -8.59 -0.43 3.49e-16 Coronary artery disease; LUSC cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg26647111 chr11:31128758 NA -0.41 -6.01 -0.31 4.9e-9 Red blood cell count; LUSC cis rs892961 0.720 rs103458 chr17:75416031 A/G cg05865280 chr17:75406074 SEPT9 0.48 10.28 0.49 9.84e-22 Airflow obstruction; LUSC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg07701084 chr6:150067640 NUP43 0.57 8.73 0.43 1.28e-16 Lung cancer; LUSC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11890956 chr21:40555474 PSMG1 1.03 20.37 0.74 1.6e-60 Cognitive function; LUSC cis rs909341 0.868 rs2236508 chr20:62333115 G/A cg09650180 chr20:62225654 GMEB2 -0.45 -5.83 -0.3 1.32e-8 Atopic dermatitis; LUSC cis rs2067615 0.507 rs1922432 chr12:107077232 G/A cg15890332 chr12:107067104 RFX4 0.34 5.77 0.3 1.84e-8 Heart rate; LUSC cis rs2836633 1.000 rs2836633 chr21:40067445 C/T cg12884169 chr21:40033163 ERG -0.56 -11.14 -0.52 1e-24 Coronary artery disease; LUSC cis rs7084921 0.640 rs12773244 chr10:101865344 G/A cg11888571 chr10:102027403 CWF19L1 -0.42 -5.9 -0.31 8.71e-9 Bone mineral density; LUSC cis rs734999 0.545 rs7364820 chr1:2556709 G/A cg18854424 chr1:2615690 NA 0.5 10.01 0.48 8.46e-21 Ulcerative colitis; LUSC cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 8.13 0.41 8.23e-15 Colorectal cancer; LUSC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg07741184 chr6:167504864 NA -0.36 -6.55 -0.34 2.14e-10 Crohn's disease; LUSC cis rs7927592 0.913 rs3740631 chr11:68341722 T/G cg20283391 chr11:68216788 NA -0.6 -8.38 -0.42 1.53e-15 Total body bone mineral density; LUSC cis rs9419702 0.538 rs9419628 chr10:133539299 A/C cg23460707 chr10:133558971 NA 0.34 5.82 0.3 1.41e-8 Survival in rectal cancer; LUSC cis rs9653442 0.835 rs11885529 chr2:100746935 A/G cg22139774 chr2:100720529 AFF3 -0.51 -9.16 -0.45 5.44e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7760949 0.963 rs9382681 chr6:13915051 A/G cg27413430 chr6:13925136 RNF182 0.55 8.15 0.41 7.28e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg08219700 chr8:58056026 NA -0.7 -8.27 -0.41 3.22e-15 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg17063962 chr7:91808500 NA 0.6 9.45 0.46 5.98e-19 Breast cancer; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg14893161 chr1:205819251 PM20D1 1.02 24.79 0.8 1.05e-77 Menarche (age at onset); LUSC cis rs1865760 0.623 rs12216125 chr6:25997458 C/T cg17691542 chr6:26056736 HIST1H1C 0.62 8.87 0.44 4.39e-17 Height; LUSC cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg26384229 chr12:38710491 ALG10B 0.8 14.16 0.61 5.55e-36 Heart rate; LUSC cis rs12908161 1.000 rs4643294 chr15:85250253 C/T cg11189052 chr15:85197271 WDR73 0.49 5.98 0.31 5.78e-9 Schizophrenia; LUSC cis rs9326248 0.581 rs4938331 chr11:116930682 C/A cg01368799 chr11:117014884 PAFAH1B2 0.61 9.31 0.45 1.77e-18 Blood protein levels; LUSC cis rs12677618 0.623 rs28506950 chr8:142261967 C/T cg00131261 chr8:142287264 NA -0.36 -6.0 -0.31 5.24e-9 Plateletcrit; LUSC cis rs16917546 1.000 rs7905030 chr10:64421600 G/C cg03961010 chr10:64397487 ZNF365 -0.42 -6.68 -0.34 9.82e-11 Basal cell carcinoma; LUSC cis rs9487051 0.735 rs396000 chr6:109519611 A/G cg01475377 chr6:109611718 NA 0.36 6.23 0.32 1.4e-9 Reticulocyte fraction of red cells; LUSC cis rs2842992 0.714 rs2475564 chr6:160123673 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.67 8.37 0.42 1.56e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs240764 0.817 rs239238 chr6:101094880 G/T cg09795085 chr6:101329169 ASCC3 0.41 5.96 0.31 6.4e-9 Neuroticism; LUSC cis rs1348850 0.668 rs6734683 chr2:178494012 C/G cg22681709 chr2:178499509 PDE11A -0.46 -7.63 -0.39 2.45e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg09877947 chr5:131593287 PDLIM4 0.37 6.0 0.31 5.04e-9 Breast cancer;Mosquito bite size; LUSC cis rs55883249 1.000 rs62119392 chr2:9714033 G/C cg23886495 chr2:9695866 ADAM17 0.49 5.66 0.3 3.24e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg17366294 chr4:99064904 C4orf37 0.57 10.18 0.49 2.27e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1044573 0.514 rs2268879 chr20:25177805 C/T cg08601574 chr20:25228251 PYGB -0.38 -5.8 -0.3 1.52e-8 Allergic rhinitis; LUSC trans rs7647973 0.626 rs4855849 chr3:49653378 A/G cg21659725 chr3:3221576 CRBN -0.69 -8.35 -0.42 1.83e-15 Menarche (age at onset); LUSC cis rs7605827 0.897 rs1990756 chr2:15616030 C/T cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs6121246 0.697 rs6088857 chr20:30226764 G/C cg21427119 chr20:30132790 HM13 -0.43 -6.38 -0.33 5.88e-10 Mean corpuscular hemoglobin; LUSC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -6.77 -0.35 5.76e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg26446133 chr18:72167187 CNDP2 -0.78 -9.64 -0.47 1.45e-19 Refractive error; LUSC cis rs3736594 0.643 rs2384655 chr2:27952235 A/T cg27432699 chr2:27873401 GPN1 -0.64 -9.09 -0.45 9.03e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs8014204 0.935 rs2300596 chr14:75353855 C/T cg06637938 chr14:75390232 RPS6KL1 0.67 11.38 0.53 1.38e-25 Caffeine consumption; LUSC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs2219968 0.961 rs4460363 chr8:78962903 G/A cg00738934 chr8:78996279 NA 0.37 6.76 0.35 6.34e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg16339924 chr4:17578868 LAP3 0.52 7.89 0.4 4.26e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3007168 0.780 rs4531642 chr14:51632063 A/T cg23942311 chr14:51606299 NA -0.36 -6.71 -0.34 8.28e-11 Cancer; LUSC cis rs6964587 1.000 rs4727266 chr7:91570129 C/T cg22117172 chr7:91764530 CYP51A1 -0.32 -5.82 -0.3 1.41e-8 Breast cancer; LUSC trans rs61931739 0.500 rs11053235 chr12:34507899 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.57 0.65 1.71e-41 Morning vs. evening chronotype; LUSC cis rs2219968 1.000 rs12056614 chr8:78962648 A/T cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3740713 1.000 rs73440615 chr11:18467283 T/C cg07915343 chr11:18477680 LDHAL6A -0.54 -6.64 -0.34 1.27e-10 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg20573242 chr4:122745356 CCNA2 0.64 9.03 0.44 1.36e-17 Type 2 diabetes; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg07507251 chr3:52567010 NT5DC2 0.33 6.61 0.34 1.49e-10 Bipolar disorder; LUSC trans rs9329221 0.967 rs7005363 chr8:10283748 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.59 -0.34 1.74e-10 Neuroticism; LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg10729496 chr3:10149963 C3orf24 0.57 7.44 0.38 8.46e-13 Alzheimer's disease; LUSC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg12463550 chr7:65579703 CRCP 0.41 5.66 0.3 3.21e-8 Aortic root size; LUSC cis rs12579753 0.833 rs1922566 chr12:82135030 T/C cg21231944 chr12:82153410 PPFIA2 -0.41 -6.22 -0.32 1.52e-9 Resting heart rate; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg00945038 chr17:61921165 SMARCD2 -0.42 -7.18 -0.37 4.45e-12 Prudent dietary pattern; LUSC cis rs910316 0.726 rs12882664 chr14:75446778 C/T cg06637938 chr14:75390232 RPS6KL1 0.51 7.77 0.39 9.7e-14 Height; LUSC cis rs2120019 0.608 rs8042558 chr15:75320433 G/T cg11632617 chr15:75315747 PPCDC -0.46 -6.16 -0.32 2.12e-9 Blood trace element (Zn levels); LUSC cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg23260525 chr10:116636907 FAM160B1 0.47 10.26 0.49 1.19e-21 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2832077 0.506 rs2832088 chr21:30158620 G/A cg08807101 chr21:30365312 RNF160 -0.49 -6.57 -0.34 1.97e-10 Cognitive test performance; LUSC trans rs6601327 0.670 rs12545250 chr8:9420566 T/C cg15556689 chr8:8085844 FLJ10661 0.45 6.41 0.33 5.08e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg07507251 chr3:52567010 NT5DC2 0.36 7.14 0.36 5.97e-12 Electroencephalogram traits; LUSC cis rs6964587 0.869 rs10276682 chr7:91486070 G/A cg17063962 chr7:91808500 NA -0.52 -7.99 -0.4 2.17e-14 Breast cancer; LUSC cis rs1775715 0.707 rs2808088 chr10:32146150 A/G cg04359828 chr10:32216031 ARHGAP12 0.41 7.09 0.36 8.13e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg13647721 chr17:30228624 UTP6 0.62 6.7 0.34 8.95e-11 Hip circumference adjusted for BMI; LUSC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg06671706 chr8:8559999 CLDN23 -0.51 -6.83 -0.35 4.09e-11 Obesity-related traits; LUSC cis rs11030122 0.702 rs995498 chr11:3967791 A/G cg18678763 chr11:4115507 RRM1 -0.46 -6.0 -0.31 5.13e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs1178968 0.901 rs4999954 chr7:72755520 A/G cg25889504 chr7:72793014 NA 0.59 8.19 0.41 5.57e-15 Triglyceride levels; LUSC trans rs11696501 0.739 rs6073820 chr20:44249272 T/A cg03272292 chr12:48577362 C12orf68 0.52 6.4 0.33 5.18e-10 Brain structure; LUSC cis rs1982963 0.950 rs2645738 chr14:52513202 G/A cg10843707 chr14:52510701 NID2 -0.41 -7.24 -0.37 3.15e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7824557 0.815 rs2736372 chr8:11106041 T/C cg21775007 chr8:11205619 TDH -0.51 -7.73 -0.39 1.24e-13 Retinal vascular caliber; LUSC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg09703963 chr11:616879 IRF7;MUPCDH -0.45 -7.15 -0.36 5.4e-12 Systemic lupus erythematosus; LUSC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg18252515 chr7:66147081 NA 1.23 14.01 0.61 2.04e-35 Diabetic kidney disease; LUSC cis rs8044995 0.563 rs73615919 chr16:68398862 C/T cg09835421 chr16:68378352 PRMT7 -0.75 -8.32 -0.41 2.31e-15 Schizophrenia; LUSC cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg03146154 chr1:46216737 IPP -0.5 -7.23 -0.37 3.29e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg24829409 chr8:58192753 C8orf71 -0.55 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs4132072 chr6:25717843 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.77 0.43 9.36e-17 Iron status biomarkers; LUSC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg00933542 chr6:150070202 PCMT1 0.34 7.04 0.36 1.07e-11 Lung cancer; LUSC cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg06636001 chr8:8085503 FLJ10661 0.62 10.05 0.48 6e-21 Mood instability; LUSC cis rs12464483 0.524 rs2593470 chr2:30887402 G/T cg17749961 chr2:30669863 LCLAT1 0.63 7.73 0.39 1.25e-13 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs2239815 0.515 rs6005917 chr22:29233486 A/G cg02153584 chr22:29168773 CCDC117 0.54 6.39 0.33 5.56e-10 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs9399135 0.967 rs9399129 chr6:135285148 C/A cg22676075 chr6:135203613 NA 0.49 7.66 0.39 2.09e-13 Red blood cell count; LUSC cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg04450456 chr4:17643702 FAM184B 0.39 6.54 0.34 2.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -6.79 -0.35 5.06e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1355223 0.525 rs10836316 chr11:34874295 C/T cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.69 -0.34 9.51e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.5 -8.41 -0.42 1.25e-15 Lymphocyte counts; LUSC cis rs2425143 0.915 rs74355238 chr20:34441541 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -6.19 -0.32 1.79e-9 Blood protein levels; LUSC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg24642844 chr7:1081250 C7orf50 -0.46 -7.45 -0.38 8.07e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11098499 1.000 rs28374891 chr4:120183550 G/A cg24375607 chr4:120327624 NA 0.75 11.25 0.52 3.99e-25 Corneal astigmatism; LUSC cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg05294307 chr14:35346193 BAZ1A -0.49 -6.2 -0.32 1.64e-9 Psoriasis; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg09177884 chr7:1199841 ZFAND2A -0.6 -8.28 -0.41 3e-15 Longevity;Endometriosis; LUSC cis rs17407555 0.518 rs16891234 chr4:9946163 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -6.67 -0.34 1.09e-10 Schizophrenia (age at onset); LUSC trans rs3942852 0.545 rs10838798 chr11:48091303 T/G cg15704280 chr7:45808275 SEPT13 -0.62 -8.09 -0.4 1.09e-14 Acute lymphoblastic leukemia (childhood); LUSC trans rs62238980 0.521 rs80342684 chr22:32380494 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs12421382 0.659 rs1371332 chr11:109381687 A/T cg11473876 chr11:109292803 C11orf87 0.39 6.33 0.33 7.97e-10 Schizophrenia; LUSC cis rs763121 0.853 rs4820345 chr22:39091151 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.64 0.57 3.41e-30 Menopause (age at onset); LUSC cis rs2377585 0.524 rs11612882 chr12:8843133 A/G cg03761649 chr12:8850719 RIMKLB -0.48 -6.62 -0.34 1.41e-10 Reticulocyte fraction of red cells; LUSC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg21361702 chr7:150065534 REPIN1 0.51 6.59 0.34 1.68e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg20135002 chr11:47629003 NA 0.49 7.7 0.39 1.53e-13 Subjective well-being; LUSC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg24209194 chr3:40518798 ZNF619 0.49 6.5 0.34 2.87e-10 Renal cell carcinoma; LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg06558623 chr16:89946397 TCF25 1.08 9.74 0.47 6.73e-20 Skin colour saturation; LUSC cis rs2857891 0.695 rs2857884 chr11:6984879 C/G cg04053776 chr11:6947353 ZNF215 0.41 6.06 0.31 3.65e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg09365446 chr1:150670422 GOLPH3L 0.47 7.0 0.36 1.4e-11 Melanoma; LUSC cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg03146154 chr1:46216737 IPP 0.51 7.71 0.39 1.5e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1950626 0.796 rs7152870 chr14:101389987 T/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.41 -7.47 -0.38 6.93e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg08807101 chr21:30365312 RNF160 -0.7 -12.17 -0.55 1.85e-28 Dental caries; LUSC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg11764359 chr7:65958608 NA 0.82 13.69 0.6 3.52e-34 Aortic root size; LUSC cis rs709400 1.000 rs8018979 chr14:104109087 G/A cg24130564 chr14:104152367 KLC1 -0.51 -7.29 -0.37 2.27e-12 Body mass index; LUSC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg04518342 chr5:131593106 PDLIM4 -0.41 -6.95 -0.36 1.88e-11 Breast cancer; LUSC cis rs9929218 0.954 rs2961 chr16:68818903 T/C cg02972257 chr16:68554789 NA 0.43 5.93 0.31 7.62e-9 Colorectal cancer; LUSC cis rs8099014 1.000 rs6566970 chr18:56122507 A/G cg12907477 chr18:56117327 MIR122 0.43 7.04 0.36 1.07e-11 Platelet count; LUSC trans rs12310956 0.510 rs7302434 chr12:33886819 G/A cg26384229 chr12:38710491 ALG10B 0.57 8.81 0.43 7.18e-17 Morning vs. evening chronotype; LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg26314531 chr2:26401878 FAM59B -0.71 -9.84 -0.47 3.17e-20 Gut microbiome composition (summer); LUSC cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg24692254 chr21:30365293 RNF160 0.91 18.67 0.71 8.51e-54 Dental caries; LUSC cis rs9326248 0.581 rs7120706 chr11:116830087 C/T cg20608306 chr11:116969690 SIK3 -0.37 -6.98 -0.36 1.56e-11 Blood protein levels; LUSC cis rs9399135 0.933 rs28384512 chr6:135376232 C/T cg22676075 chr6:135203613 NA 0.47 7.34 0.37 1.66e-12 Red blood cell count; LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg25767906 chr1:53392781 SCP2 0.6 11.66 0.54 1.39e-26 Monocyte count; LUSC cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.31 -0.33 8.67e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg00149659 chr3:10157352 C3orf10 1.01 14.37 0.62 8.51e-37 Alzheimer's disease; LUSC cis rs155346 0.948 rs265141 chr5:139396375 G/A cg01090482 chr5:139365336 NRG2 -0.36 -5.98 -0.31 5.7e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.78e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 9.29 0.45 1.98e-18 Hip circumference adjusted for BMI; LUSC cis rs11630290 0.628 rs72752941 chr15:64181604 G/C cg12036633 chr15:63758958 NA -0.67 -6.91 -0.35 2.43e-11 Iris characteristics; LUSC cis rs7945718 0.934 rs7114040 chr11:12781659 C/T cg25843174 chr11:12811716 TEAD1 -0.32 -7.35 -0.37 1.51e-12 Educational attainment (years of education); LUSC cis rs4253772 0.530 rs9615349 chr22:46732418 T/G cg00784671 chr22:46762841 CELSR1 -0.49 -5.92 -0.31 7.96e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7223966 1.000 rs13380863 chr17:61780793 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.53 0.34 2.46e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg12432903 chr7:1882776 MAD1L1 -0.42 -6.8 -0.35 4.75e-11 Bipolar disorder and schizophrenia; LUSC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg19046167 chr17:80928561 B3GNTL1 0.4 6.44 0.33 4.21e-10 Breast cancer; LUSC cis rs4356932 1.000 rs10000130 chr4:76939335 T/C cg00809888 chr4:76862425 NAAA 0.35 5.87 0.31 1.08e-8 Blood protein levels; LUSC cis rs1005224 0.895 rs11624114 chr14:76131800 A/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.64 -8.76 -0.43 1.03e-16 Large artery stroke; LUSC cis rs7617773 0.817 rs6800492 chr3:48323890 G/A cg20734569 chr3:48348370 SPINK8 -0.47 -8.21 -0.41 4.82e-15 Coronary artery disease; LUSC cis rs6723226 0.739 rs2069213 chr2:32743084 C/T cg02381751 chr2:32503542 YIPF4 0.59 9.02 0.44 1.46e-17 Intelligence (multi-trait analysis); LUSC cis rs1044826 1.000 rs12695698 chr3:139175781 A/G cg00490450 chr3:139108681 COPB2 -0.52 -7.03 -0.36 1.2e-11 Obesity-related traits; LUSC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg11366901 chr6:160182831 ACAT2 0.92 12.58 0.57 5.65e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs72781680 1.000 rs72796357 chr2:24160131 A/G cg20701182 chr2:24300061 SF3B14 0.57 5.87 0.31 1.04e-8 Lymphocyte counts; LUSC trans rs3806843 1.000 rs1548699 chr5:140164918 T/C cg25815440 chr2:42134162 NA -0.25 -5.96 -0.31 6.49e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs3087591 0.922 rs2905879 chr17:29545431 T/A cg24425628 chr17:29625626 OMG;NF1 0.56 8.21 0.41 5.04e-15 Hip circumference; LUSC cis rs2084898 0.550 rs470411 chr11:120012390 G/C cg07435449 chr11:120005650 TRIM29 0.36 6.26 0.32 1.15e-9 Stroke (pediatric); LUSC cis rs11098499 0.908 rs28499576 chr4:120386677 G/A cg09307838 chr4:120376055 NA 0.79 11.57 0.53 2.96e-26 Corneal astigmatism; LUSC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg12560992 chr17:57184187 TRIM37 0.83 14.9 0.63 7.77e-39 Intelligence (multi-trait analysis); LUSC cis rs12579753 0.879 rs11115007 chr12:82164673 A/T cg21231944 chr12:82153410 PPFIA2 -0.4 -6.37 -0.33 6.21e-10 Resting heart rate; LUSC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg06134567 chr22:46658398 PKDREJ -0.53 -5.93 -0.31 7.54e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs1322512 0.958 rs12195158 chr6:153006544 T/C cg03415253 chr6:152958462 SYNE1 0.38 5.65 0.3 3.38e-8 Tonometry; LUSC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg03605463 chr16:89740564 NA 0.58 9.2 0.45 3.93e-18 Vitiligo; LUSC cis rs9937943 0.667 rs9938426 chr16:74523739 C/G cg01733217 chr16:74700730 RFWD3 -0.6 -6.97 -0.36 1.67e-11 Neutrophil percentage of white cells; LUSC cis rs1728785 1.000 rs1728801 chr16:68571457 A/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg14895029 chr7:2775587 GNA12 -0.45 -6.69 -0.34 9.21e-11 Height; LUSC cis rs17102423 0.755 rs8009396 chr14:65573438 C/G cg11161011 chr14:65562177 MAX -0.81 -12.19 -0.55 1.57e-28 Obesity-related traits; LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.98 -0.44 2.02e-17 Bipolar disorder; LUSC cis rs7119 0.717 rs12910951 chr15:77806797 A/G cg27398640 chr15:77910606 LINGO1 -0.29 -6.12 -0.32 2.58e-9 Type 2 diabetes; LUSC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg15145296 chr3:125709740 NA -0.57 -6.42 -0.33 4.8e-10 Blood pressure (smoking interaction); LUSC cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg19628046 chr18:33552617 C18orf21 0.5 6.12 0.32 2.56e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs4363385 0.510 rs6686526 chr1:153044996 T/C cg00922841 chr1:152955080 SPRR1A -0.36 -6.07 -0.32 3.4e-9 Inflammatory skin disease; LUSC trans rs11098499 0.863 rs12498539 chr4:120468370 C/T cg25214090 chr10:38739885 LOC399744 0.54 7.98 0.4 2.39e-14 Corneal astigmatism; LUSC cis rs2637266 0.714 rs4475870 chr10:78450724 T/A cg18941641 chr10:78392320 NA 0.33 5.98 0.31 5.67e-9 Pulmonary function; LUSC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg06637938 chr14:75390232 RPS6KL1 0.53 8.41 0.42 1.23e-15 Height; LUSC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.59 -0.34 1.71e-10 Schizophrenia; LUSC cis rs3126085 0.935 rs7531094 chr1:152176850 A/G cg03465714 chr1:152285911 FLG -0.4 -5.67 -0.3 3.09e-8 Atopic dermatitis; LUSC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg12963246 chr6:28129442 ZNF389 0.5 6.7 0.34 8.76e-11 Depression; LUSC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg18252515 chr7:66147081 NA -1.25 -13.99 -0.61 2.56e-35 Diabetic kidney disease; LUSC trans rs6747952 0.899 rs4663856 chr2:239089624 C/A cg17763188 chr8:6692148 XKR5 0.37 5.97 0.31 6.13e-9 Mean corpuscular hemoglobin concentration; LUSC cis rs7106204 0.609 rs12276488 chr11:24250211 G/A ch.11.24196551F chr11:24239977 NA 0.76 7.19 0.37 4.39e-12 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1372520 0.684 rs2619347 chr4:90745770 G/A cg15133208 chr4:90757351 SNCA -0.54 -8.45 -0.42 9.02e-16 Neuroticism; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg22907277 chr7:1156413 C7orf50 0.51 7.73 0.39 1.25e-13 Longevity;Endometriosis; LUSC cis rs870825 0.655 rs7683556 chr4:185632019 T/A cg04058563 chr4:185651563 MLF1IP 0.87 13.33 0.59 8.18e-33 Blood protein levels; LUSC cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.59 0.43 3.45e-16 Menopause (age at onset); LUSC cis rs13266463 1.000 rs13266463 chr8:143403693 A/G cg16886403 chr8:143471632 TSNARE1 -0.6 -8.98 -0.44 2.04e-17 Schizophrenia; LUSC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.89e-16 Menopause (age at onset); LUSC cis rs448720 0.806 rs11071966 chr15:68163774 G/A cg08079166 chr15:68083412 MAP2K5 -0.28 -5.68 -0.3 2.87e-8 Cognitive performance; LUSC cis rs66573146 1.000 rs6838250 chr4:6973184 C/G cg02503808 chr4:7069936 GRPEL1 -0.86 -6.14 -0.32 2.29e-9 Granulocyte percentage of myeloid white cells; LUSC trans rs61931739 0.500 rs10772163 chr12:34532950 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.72 -0.39 1.36e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg12365402 chr11:9010492 NRIP3 0.43 7.7 0.39 1.56e-13 Hemoglobin concentration; LUSC cis rs4654899 0.743 rs61781069 chr1:21130735 T/C cg02927042 chr1:21476669 EIF4G3 -0.38 -5.97 -0.31 6.1e-9 Superior frontal gyrus grey matter volume; LUSC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.88 -0.44 4.17e-17 Lung cancer; LUSC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg09085632 chr11:111637200 PPP2R1B -1.04 -16.23 -0.66 4.23e-44 Primary sclerosing cholangitis; LUSC trans rs1486139 1.000 rs723289 chr7:46283474 C/T cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg12463550 chr7:65579703 CRCP -0.5 -7.29 -0.37 2.27e-12 Aortic root size; LUSC cis rs2688608 0.653 rs12775558 chr10:75570868 G/A cg23231163 chr10:75533350 FUT11 -0.46 -7.39 -0.37 1.17e-12 Inflammatory bowel disease; LUSC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg14440974 chr22:39074834 NA -0.35 -5.79 -0.3 1.6e-8 Menopause (age at onset); LUSC cis rs7927592 0.513 rs689075 chr11:68194432 A/C cg01657329 chr11:68192670 LRP5 -0.48 -7.42 -0.38 9.63e-13 Total body bone mineral density; LUSC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg13390004 chr1:15929781 NA 0.42 6.95 0.36 1.92e-11 Systolic blood pressure; LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg21724239 chr8:58056113 NA -0.78 -8.8 -0.43 7.23e-17 Developmental language disorder (linguistic errors); LUSC cis rs208520 1.000 rs12189683 chr6:66977716 A/C cg07460842 chr6:66804631 NA -0.92 -12.08 -0.55 4.17e-28 Exhaled nitric oxide output; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg02423579 chr7:2872169 GNA12 -0.45 -6.33 -0.33 8.07e-10 Height; LUSC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg24675056 chr1:15929824 NA 0.49 8.51 0.42 6.13e-16 Systolic blood pressure; LUSC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.66 -6.43 -0.33 4.49e-10 Cerebrospinal P-tau181p levels; LUSC cis rs1044826 0.642 rs295473 chr3:139215585 T/C cg00490450 chr3:139108681 COPB2 0.46 7.03 0.36 1.19e-11 Obesity-related traits; LUSC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs28785552 0.800 rs10853854 chr19:53232128 A/G cg10871876 chr19:53194124 ZNF83 -0.55 -8.57 -0.42 3.78e-16 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs9467773 0.620 rs2451731 chr6:26624822 A/C cg09904177 chr6:26538194 HMGN4 0.65 11.61 0.54 2.14e-26 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg17971929 chr21:40555470 PSMG1 0.77 13.46 0.59 2.8e-33 Cognitive function; LUSC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg21361702 chr7:150065534 REPIN1 0.57 8.02 0.4 1.85e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs3087591 0.960 rs2905872 chr17:29525027 C/A cg24425628 chr17:29625626 OMG;NF1 0.55 8.0 0.4 2.02e-14 Hip circumference; LUSC cis rs7927771 0.524 rs10742817 chr11:47689343 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -6.74 -0.35 6.93e-11 Subjective well-being; LUSC trans rs1376359 0.537 rs506864 chr1:103281950 A/T cg17154563 chr19:40477487 PSMC4 0.47 5.95 0.31 6.82e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -5.9 -0.31 9.1e-9 Developmental language disorder (linguistic errors); LUSC cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg24642439 chr20:33292090 TP53INP2 0.51 7.63 0.39 2.51e-13 Height; LUSC cis rs2227564 0.700 rs2688613 chr10:75653045 C/T cg23231163 chr10:75533350 FUT11 -0.42 -5.93 -0.31 7.45e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg03526776 chr6:41159608 TREML2 0.33 6.33 0.33 7.7e-10 Alzheimer's disease (late onset); LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18404041 chr3:52824283 ITIH1 -0.53 -10.19 -0.49 2.01e-21 Electroencephalogram traits; LUSC cis rs7246967 0.673 rs3853649 chr19:22880460 C/G cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg20573242 chr4:122745356 CCNA2 -0.45 -7.07 -0.36 9.27e-12 Type 2 diabetes; LUSC cis rs11098499 0.863 rs10009626 chr4:120470005 T/C cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.66e-25 Corneal astigmatism; LUSC cis rs2274273 0.870 rs946059 chr14:55847466 A/G cg04306507 chr14:55594613 LGALS3 0.56 12.98 0.58 1.81e-31 Protein biomarker; LUSC cis rs9902453 0.933 rs60694493 chr17:28473256 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 8.08 0.4 1.17e-14 Coffee consumption (cups per day); LUSC cis rs4727027 0.704 rs1123992 chr7:148907201 C/G cg23158103 chr7:148848205 ZNF398 -0.39 -6.01 -0.31 4.77e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg10150615 chr22:24372951 LOC391322 -0.35 -5.74 -0.3 2.09e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg18357526 chr6:26021779 HIST1H4A -0.38 -6.19 -0.32 1.8e-9 Intelligence (multi-trait analysis); LUSC cis rs9815354 0.812 rs73081370 chr3:41916258 G/C cg03022575 chr3:42003672 ULK4 0.83 8.57 0.42 3.85e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs2018683 0.624 rs2286220 chr7:28998699 G/C cg19402173 chr7:128379420 CALU -0.51 -7.55 -0.38 4.11e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg13319975 chr6:146136371 FBXO30 -0.41 -6.15 -0.32 2.16e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs4906332 1.000 rs35862113 chr14:103857229 G/T cg04998671 chr14:104000505 TRMT61A -0.47 -7.15 -0.36 5.44e-12 Coronary artery disease; LUSC cis rs4664308 0.870 rs55959207 chr2:161016981 A/C cg03641300 chr2:160917029 PLA2R1 -0.64 -10.92 -0.51 6.16e-24 Idiopathic membranous nephropathy; LUSC cis rs2274273 0.967 rs10137409 chr14:55611441 A/C cg04306507 chr14:55594613 LGALS3 0.54 11.95 0.55 1.23e-27 Protein biomarker; LUSC cis rs7107174 1.000 rs55825352 chr11:78034424 C/T cg02023728 chr11:77925099 USP35 0.48 6.89 0.35 2.87e-11 Testicular germ cell tumor; LUSC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg18350739 chr11:68623251 NA -0.38 -6.56 -0.34 2.01e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg07148914 chr20:33460835 GGT7 0.55 8.25 0.41 3.64e-15 Height; LUSC cis rs1832871 0.672 rs62437159 chr6:158697705 C/T cg07165851 chr6:158734300 TULP4 0.5 7.78 0.39 9.42e-14 Height; LUSC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg17366294 chr4:99064904 C4orf37 0.58 10.43 0.5 3.19e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs3903072 0.528 rs12800497 chr11:65579762 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.35 5.77 0.3 1.77e-8 Breast cancer; LUSC cis rs9905704 0.681 rs1468540 chr17:56561942 C/T cg19466818 chr17:56409534 MIR142 0.35 6.44 0.33 4.06e-10 Testicular germ cell tumor; LUSC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg06671706 chr8:8559999 CLDN23 0.49 6.73 0.35 7.55e-11 Obesity-related traits; LUSC cis rs7572644 0.766 rs6758799 chr2:28284633 T/C cg27432699 chr2:27873401 GPN1 -0.54 -6.9 -0.35 2.67e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs208520 1.000 rs12193077 chr6:66989548 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.9 0.55 1.88e-27 Exhaled nitric oxide output; LUSC cis rs7923609 0.934 rs2893919 chr10:65134778 G/A cg01631684 chr10:65280961 REEP3 -0.38 -5.89 -0.31 9.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs75804782 0.581 rs13415491 chr2:239319901 C/T cg01134436 chr17:81009848 B3GNTL1 0.64 6.08 0.32 3.37e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.74 -0.3 2.14e-8 Depression; LUSC trans rs2739330 0.828 rs5751770 chr22:24252842 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.53 -8.17 -0.41 6.23e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6084875 0.812 rs2050369 chr20:4719493 C/T cg07258627 chr20:4721683 PRNT -0.33 -6.05 -0.31 3.99e-9 Systemic lupus erythematosus; LUSC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg11764359 chr7:65958608 NA -0.7 -10.84 -0.51 1.18e-23 Aortic root size; LUSC cis rs7107174 1.000 rs901104 chr11:77930499 C/T cg02023728 chr11:77925099 USP35 0.53 7.25 0.37 3e-12 Testicular germ cell tumor; LUSC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg06634786 chr22:41940651 POLR3H 0.51 5.91 0.31 8.59e-9 Vitiligo; LUSC cis rs2235544 0.579 rs11804837 chr1:54482915 G/A cg25741118 chr1:54482237 LDLRAD1 -0.33 -7.57 -0.38 3.6e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg16325326 chr1:53192061 ZYG11B -0.92 -17.21 -0.69 5.71e-48 Monocyte count; LUSC cis rs8028313 0.731 rs6494678 chr15:67946247 C/T cg27219399 chr15:67835830 MAP2K5 0.36 5.9 0.31 9.02e-9 Obesity; LUSC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.76e-13 Schizophrenia; LUSC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs16976116 0.855 rs11856010 chr15:55495008 A/G cg11288833 chr15:55489084 RSL24D1 0.49 5.8 0.3 1.53e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3857067 0.806 rs11943926 chr4:95136512 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.29 -0.33 9.86e-10 QT interval; LUSC cis rs6121246 0.697 rs6088864 chr20:30228157 G/A cg13852791 chr20:30311386 BCL2L1 0.85 10.37 0.49 4.99e-22 Mean corpuscular hemoglobin; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03651680 chr2:46926842 SOCS5 0.36 5.96 0.31 6.51e-9 Triglycerides; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19354851 chr1:94375246 GCLM -0.42 -6.33 -0.33 7.75e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs868036 0.681 rs4776978 chr15:68108305 A/G cg24579218 chr15:68104479 NA -0.39 -6.78 -0.35 5.39e-11 Restless legs syndrome; LUSC cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg13852791 chr20:30311386 BCL2L1 0.82 10.81 0.51 1.42e-23 Mean corpuscular hemoglobin; LUSC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.03e-34 Prostate cancer; LUSC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg06740227 chr12:86229804 RASSF9 0.45 7.09 0.36 7.86e-12 Major depressive disorder; LUSC cis rs1113500 0.787 rs473704 chr1:108637310 T/C cg06207961 chr1:108661230 NA -0.31 -5.74 -0.3 2.13e-8 Growth-regulated protein alpha levels; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg08888203 chr3:10149979 C3orf24 0.64 8.67 0.43 1.9e-16 Alzheimer's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04505727 chr17:79885823 LOC92659;MAFG -0.41 -6.25 -0.32 1.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg16405210 chr4:1374714 KIAA1530 -0.54 -8.28 -0.41 2.93e-15 Obesity-related traits; LUSC cis rs12900413 0.687 rs7176948 chr15:90315707 A/C cg24249390 chr15:90295951 MESP1 -0.37 -5.75 -0.3 2.05e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg11764359 chr7:65958608 NA 0.49 6.09 0.32 3.19e-9 Aortic root size; LUSC trans rs2797160 1.000 rs1777194 chr6:126004883 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.74 -0.35 6.9e-11 Endometrial cancer; LUSC cis rs2692947 0.800 rs2692936 chr2:96745729 G/A cg22654517 chr2:96458247 NA 0.33 6.13 0.32 2.51e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg01475377 chr6:109611718 NA -0.46 -8.44 -0.42 9.54e-16 Reticulocyte fraction of red cells; LUSC cis rs2795502 0.938 rs2744085 chr10:43341976 C/T cg20628663 chr10:43360327 NA 0.74 10.68 0.5 4.23e-23 Blood protein levels; LUSC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg15704280 chr7:45808275 SEPT13 -1.04 -18.08 -0.7 2.04e-51 Coronary artery disease; LUSC cis rs922692 0.744 rs1825087 chr15:79077114 A/G cg00540400 chr15:79124168 NA -0.41 -7.06 -0.36 9.95e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10761482 0.861 rs1903204 chr10:62100231 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs6964587 1.000 rs10225885 chr7:91671007 A/G cg22709100 chr7:91322751 NA 0.4 5.85 0.31 1.15e-8 Breast cancer; LUSC trans rs4650994 0.507 rs12405456 chr1:178512331 T/G cg05059571 chr16:84539110 KIAA1609 -0.45 -8.64 -0.43 2.35e-16 HDL cholesterol levels;HDL cholesterol; LUSC cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg08873628 chr1:175162347 KIAA0040 0.39 5.67 0.3 3.14e-8 Alcohol dependence; LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg03579872 chr1:53393473 SCP2 0.39 5.71 0.3 2.49e-8 Monocyte count; LUSC cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg13902645 chr11:5959945 NA -0.64 -9.11 -0.45 7.48e-18 DNA methylation (variation); LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.95 -0.58 2.36e-31 Platelet count; LUSC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg18876405 chr7:65276391 NA -0.69 -12.3 -0.56 6.19e-29 Aortic root size; LUSC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.51 -6.74 -0.35 6.91e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs763121 0.853 rs138709 chr22:39139216 C/G cg06544989 chr22:39130855 UNC84B 0.35 6.11 0.32 2.72e-9 Menopause (age at onset); LUSC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg05729581 chr11:3078854 CARS -0.51 -7.91 -0.4 3.86e-14 Longevity; LUSC cis rs72781680 0.846 rs72782114 chr2:24025740 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.45e-8 Lymphocyte counts; LUSC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg19748678 chr4:122722346 EXOSC9 0.71 10.84 0.51 1.18e-23 Type 2 diabetes; LUSC cis rs4820539 0.902 rs9612237 chr22:23472954 T/C cg21100191 chr22:23484243 RTDR1 0.91 16.03 0.66 2.81e-43 Bone mineral density; LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.48 8.23 0.41 4.38e-15 Bipolar disorder; LUSC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg19318889 chr4:1322082 MAEA 0.55 9.09 0.45 8.89e-18 Obesity-related traits; LUSC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg22800045 chr5:56110881 MAP3K1 0.58 7.81 0.39 7.43e-14 Coronary artery disease; LUSC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg00701064 chr4:6280414 WFS1 0.58 14.2 0.61 3.82e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.71 -0.43 1.43e-16 Bipolar disorder; LUSC cis rs2147959 0.714 rs6659690 chr1:228628170 A/G cg18477163 chr1:228402036 OBSCN -0.42 -5.86 -0.31 1.08e-8 Adult asthma; LUSC cis rs2486288 0.656 rs2413771 chr15:45553140 A/G cg04036182 chr15:45458818 NA -0.35 -5.76 -0.3 1.96e-8 Glomerular filtration rate; LUSC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg26677194 chr12:130822605 PIWIL1 0.61 8.74 0.43 1.17e-16 Menopause (age at onset); LUSC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs3125734 0.671 rs3852406 chr10:64015162 T/C cg09941381 chr10:64027924 RTKN2 -0.37 -6.92 -0.35 2.38e-11 Rheumatoid arthritis; LUSC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg00857998 chr1:205179979 DSTYK 0.64 9.81 0.47 4.01e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg17303459 chr19:54606023 NDUFA3 0.44 6.98 0.36 1.61e-11 Risky sexual behaviors in alcohol dependence; LUSC cis rs3925075 1.000 rs3925074 chr16:31347807 G/A cg02846316 chr16:31340340 ITGAM 0.36 6.76 0.35 6.34e-11 IgA nephropathy; LUSC cis rs11158026 0.526 rs11626210 chr14:55349549 C/T cg04306507 chr14:55594613 LGALS3 0.4 6.4 0.33 5.16e-10 Parkinson's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16426870 chr16:23652487 PALB2;DCTN5 -0.36 -5.95 -0.31 6.85e-9 Electrocardiographic conduction measures; LUSC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg27266027 chr21:40555129 PSMG1 -0.41 -5.93 -0.31 7.65e-9 Cognitive function; LUSC cis rs3755132 0.929 rs6724800 chr2:15786243 A/G cg12888861 chr2:15731646 DDX1 0.53 7.51 0.38 5.53e-13 Wilms tumor; LUSC cis rs77633900 0.614 rs2930681 chr15:76995150 G/A cg21673338 chr15:77095150 SCAPER -0.81 -8.33 -0.41 2.19e-15 Non-glioblastoma glioma;Glioma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08275802 chr7:155137875 NA -0.38 -5.94 -0.31 7.01e-9 Electrocardiographic conduction measures; LUSC cis rs8099014 1.000 rs12608175 chr18:56129976 T/C cg12907477 chr18:56117327 MIR122 0.44 7.04 0.36 1.11e-11 Platelet count; LUSC cis rs9486715 0.867 rs7451950 chr6:96879974 T/C cg06623918 chr6:96969491 KIAA0776 0.93 17.58 0.69 1.94e-49 Headache; LUSC cis rs240764 0.578 rs6925065 chr6:101178856 C/T cg09795085 chr6:101329169 ASCC3 0.44 6.32 0.33 8.43e-10 Neuroticism; LUSC cis rs7296418 0.738 rs10846489 chr12:123743927 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.34 6.54 0.34 2.26e-10 Platelet count; LUSC cis rs2580764 0.565 rs6545466 chr2:55228392 C/T cg20993754 chr2:55226987 RTN4 0.34 5.81 0.3 1.5e-8 Mean platelet volume; LUSC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC trans rs12310956 0.532 rs1852226 chr12:33962940 G/A cg13010199 chr12:38710504 ALG10B 0.5 7.48 0.38 6.51e-13 Morning vs. evening chronotype; LUSC cis rs3813567 0.759 rs7163204 chr15:78953740 G/A cg04896959 chr15:78267971 NA -0.42 -6.72 -0.34 8.09e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg02466173 chr16:30829666 NA -0.68 -16.06 -0.66 2.09e-43 Dementia with Lewy bodies; LUSC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg20908204 chr19:46285434 DMPK -0.46 -8.85 -0.44 5.11e-17 Coronary artery disease; LUSC cis rs7937682 1.000 rs2186839 chr11:111534442 T/G cg22437258 chr11:111473054 SIK2 0.47 6.38 0.33 6.07e-10 Primary sclerosing cholangitis; LUSC cis rs2439831 0.850 rs8032649 chr15:44134922 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.83 -8.66 -0.43 2.11e-16 Lung cancer in ever smokers; LUSC cis rs7833986 0.501 rs2668007 chr8:56944111 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.7 10.0 0.48 9.03e-21 Height; LUSC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.69e-14 Systolic blood pressure; LUSC cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg18681998 chr4:17616180 MED28 0.78 13.81 0.6 1.26e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg02423579 chr7:2872169 GNA12 -0.41 -6.08 -0.32 3.34e-9 Height; LUSC cis rs870825 0.860 rs72689277 chr4:185593699 G/A cg04058563 chr4:185651563 MLF1IP 0.87 12.31 0.56 5.94e-29 Blood protein levels; LUSC cis rs9467711 0.606 rs9379856 chr6:26366836 A/C cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg25072359 chr17:41440525 NA 0.65 9.4 0.46 9.22e-19 Menopause (age at onset); LUSC cis rs6912958 0.712 rs6454640 chr6:88370352 G/T cg04972856 chr6:88032051 C6orf162;GJB7 0.36 6.7 0.34 9.05e-11 Monocyte percentage of white cells; LUSC cis rs7100689 0.577 rs1340385 chr10:82058851 G/A cg00277334 chr10:82204260 NA -0.42 -5.78 -0.3 1.69e-8 Post bronchodilator FEV1; LUSC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg04287289 chr16:89883240 FANCA 0.53 8.02 0.4 1.76e-14 Vitiligo; LUSC cis rs8014204 0.587 rs6574201 chr14:75387256 T/C cg03030879 chr14:75389066 RPS6KL1 0.39 7.42 0.38 9.79e-13 Caffeine consumption; LUSC cis rs1448094 0.967 rs10746357 chr12:86341044 A/T cg00310523 chr12:86230176 RASSF9 0.39 7.0 0.36 1.4e-11 Major depressive disorder; LUSC cis rs8114671 0.967 rs6060285 chr20:33770487 G/T cg24642439 chr20:33292090 TP53INP2 0.41 5.93 0.31 7.42e-9 Height; LUSC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg10207240 chr12:122356781 WDR66 0.46 6.61 0.34 1.49e-10 Mean corpuscular volume; LUSC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg15704280 chr7:45808275 SEPT13 -1.13 -24.87 -0.81 5.13e-78 Height; LUSC cis rs1018836 0.828 rs12547016 chr8:91563847 T/C cg16814680 chr8:91681699 NA -0.69 -11.11 -0.52 1.28e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs11864453 0.826 rs2240243 chr16:72137561 A/G cg16558253 chr16:72132732 DHX38 0.44 6.74 0.35 7.17e-11 Fibrinogen levels; LUSC cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.07e-12 Motion sickness; LUSC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 11.58 0.54 2.63e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.657 rs9996569 chr4:120299004 G/C cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs9467711 0.659 rs72844462 chr6:26563864 A/C cg09904177 chr6:26538194 HMGN4 -0.76 -5.9 -0.31 8.78e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7586879 0.828 rs13387053 chr2:25103025 G/A cg01884057 chr2:25150051 NA 0.41 8.53 0.42 5.31e-16 Body mass index; LUSC trans rs7615952 0.546 rs2979350 chr3:125362215 T/C cg07211511 chr3:129823064 LOC729375 -0.53 -6.1 -0.32 2.86e-9 Blood pressure (smoking interaction); LUSC cis rs72627509 0.904 rs17081933 chr4:57822869 T/A cg26694713 chr4:57773883 REST 0.49 5.88 0.31 1.01e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg12292205 chr6:26970375 C6orf41 -0.67 -11.36 -0.53 1.61e-25 Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -16.62 -0.67 1.2e-45 Monocyte count; LUSC cis rs34172651 0.917 rs2112786 chr16:24778944 C/T cg04756594 chr16:24857601 SLC5A11 0.33 5.65 0.3 3.41e-8 Intelligence (multi-trait analysis); LUSC cis rs752010 0.806 rs4641303 chr1:42091310 A/G cg06885757 chr1:42089581 HIVEP3 0.49 10.05 0.48 6.05e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs4242434 0.889 rs11785755 chr8:22453223 C/A cg03733263 chr8:22462867 KIAA1967 0.97 16.67 0.67 7.76e-46 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2115536 1.000 rs2115536 chr15:80194247 C/T cg00225070 chr15:80189496 MTHFS 0.57 8.91 0.44 3.39e-17 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg09184832 chr6:79620586 NA -0.36 -5.72 -0.3 2.39e-8 Intelligence (multi-trait analysis); LUSC cis rs28830936 1.000 rs9672360 chr15:41912411 T/C cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.28 -0.32 1.06e-9 Diastolic blood pressure; LUSC cis rs3857536 0.673 rs7759888 chr6:66891922 T/C cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs3809566 0.963 rs12148057 chr15:63331509 A/T cg00520135 chr15:63333846 TPM1 -0.33 -6.66 -0.34 1.12e-10 Platelet count; LUSC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg11102782 chr19:18549136 ISYNA1 -0.37 -6.98 -0.36 1.56e-11 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05203659 chr16:12009378 GSPT1 0.46 7.03 0.36 1.14e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg06008330 chr7:65541103 ASL -0.4 -6.22 -0.32 1.46e-9 Aortic root size; LUSC cis rs10088262 0.629 rs7015861 chr8:124795613 C/T cg02993010 chr8:124780839 FAM91A1 -0.47 -5.67 -0.3 3.02e-8 Pancreatic cancer; LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg27170947 chr2:26402098 FAM59B 0.66 8.94 0.44 2.78e-17 Gut microbiome composition (summer); LUSC cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg17173187 chr15:85201210 NMB 0.48 9.17 0.45 4.85e-18 Schizophrenia; LUSC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg16049864 chr8:95962084 TP53INP1 -0.61 -11.34 -0.53 1.95e-25 Type 2 diabetes; LUSC cis rs62064224 0.589 rs756785 chr17:30812845 T/C cg18200150 chr17:30822561 MYO1D 0.31 6.01 0.31 4.88e-9 Schizophrenia; LUSC trans rs9329221 0.870 rs11777976 chr8:10255402 A/G cg08975724 chr8:8085496 FLJ10661 -0.5 -7.25 -0.37 2.99e-12 Neuroticism; LUSC cis rs727505 0.789 rs9641761 chr7:124735205 A/T cg23710748 chr7:124431027 NA -0.4 -6.96 -0.36 1.79e-11 Lewy body disease; LUSC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg13699009 chr12:122356056 WDR66 0.49 7.72 0.39 1.39e-13 Mean corpuscular volume; LUSC cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.9 0.44 3.72e-17 Menopause (age at onset); LUSC cis rs7113850 0.541 rs7935630 chr11:24222206 A/C ch.11.24196551F chr11:24239977 NA 0.99 8.89 0.44 3.77e-17 Bone fracture in osteoporosis; LUSC cis rs9611519 0.780 rs3171692 chr22:41642212 C/T cg13813247 chr22:41461852 NA -0.32 -5.92 -0.31 7.95e-9 Neuroticism; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg26716323 chr7:22862328 TOMM7 0.39 6.02 0.31 4.63e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2073300 1.000 rs79255223 chr20:23443559 G/T cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg18904891 chr8:8559673 CLDN23 0.62 8.63 0.43 2.49e-16 Obesity-related traits; LUSC cis rs892961 0.932 rs3987885 chr17:75414990 A/G cg05865280 chr17:75406074 SEPT9 0.46 9.61 0.47 1.86e-19 Airflow obstruction; LUSC cis rs9814567 1.000 rs9869981 chr3:134248801 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs826838 0.967 rs980572 chr12:39127673 A/C cg26384229 chr12:38710491 ALG10B 0.8 14.61 0.62 1.02e-37 Heart rate; LUSC cis rs5769765 0.862 rs7410537 chr22:50317330 G/A cg08270630 chr22:50330655 NA -0.44 -6.59 -0.34 1.75e-10 Schizophrenia; LUSC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.79e-9 Vitiligo; LUSC cis rs2637266 0.626 rs846619 chr10:78545449 A/G cg18941641 chr10:78392320 NA 0.38 6.75 0.35 6.54e-11 Pulmonary function; LUSC cis rs9326248 0.581 rs11216267 chr11:116952392 C/T cg26566898 chr11:117069891 TAGLN 0.34 6.56 0.34 2.01e-10 Blood protein levels; LUSC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 11.91 0.55 1.63e-27 Hip circumference adjusted for BMI; LUSC cis rs262150 0.566 rs262159 chr7:158772172 C/T cg22153799 chr7:158819822 NA -0.34 -6.07 -0.31 3.57e-9 Facial morphology (factor 20); LUSC cis rs2274273 0.712 rs9806049 chr14:55525589 C/A cg04306507 chr14:55594613 LGALS3 0.48 10.38 0.49 4.52e-22 Protein biomarker; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15190599 chr6:26156487 HIST1H1E 0.42 6.57 0.34 1.95e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4595586 0.545 rs12823487 chr12:39391286 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs240764 0.817 rs239219 chr6:101116146 C/T cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs12681287 0.640 rs67123356 chr8:87453992 A/C cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs1908814 0.516 rs35391955 chr8:11796728 A/C cg00262122 chr8:11665843 FDFT1 0.39 5.82 0.3 1.37e-8 Neuroticism; LUSC cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg19508488 chr2:152266495 RIF1 0.54 7.64 0.39 2.33e-13 Lung cancer; LUSC cis rs6714710 0.580 rs13032265 chr2:98409565 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.78 13.73 0.6 2.5e-34 Total body bone mineral density; LUSC cis rs709400 0.930 rs28513222 chr14:104028069 A/T cg24130564 chr14:104152367 KLC1 -0.47 -6.64 -0.34 1.24e-10 Body mass index; LUSC cis rs10876993 0.672 rs2640611 chr12:58037757 T/A cg18357645 chr12:58087776 OS9 0.5 7.42 0.38 9.78e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg18230493 chr5:56204884 C5orf35 -0.93 -13.74 -0.6 2.25e-34 Initial pursuit acceleration; LUSC cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg26384229 chr12:38710491 ALG10B 0.92 15.6 0.65 1.41e-41 Bladder cancer; LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg08470875 chr2:26401718 FAM59B 0.73 9.87 0.48 2.53e-20 Gut microbiome composition (summer); LUSC cis rs1577917 0.771 rs2758847 chr6:86349103 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.83 -0.43 6.18e-17 Response to antipsychotic treatment; LUSC trans rs4332037 0.707 rs62435130 chr7:1890002 C/T cg11693508 chr17:37793320 STARD3 0.51 6.27 0.32 1.09e-9 Bipolar disorder; LUSC trans rs2832077 0.527 rs9981922 chr21:30212718 A/G cg14791747 chr16:20752902 THUMPD1 0.76 13.09 0.58 7.07e-32 Cognitive test performance; LUSC cis rs72634258 1.000 rs72634258 chr1:8150638 T/C cg00042356 chr1:8021962 PARK7 0.84 10.18 0.49 2.24e-21 Inflammatory bowel disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03809994 chr4:75023664 MTHFD2L -0.48 -6.33 -0.33 8.11e-10 Bipolar disorder and schizophrenia; LUSC cis rs7584330 0.955 rs6729659 chr2:238385126 T/C cg14458575 chr2:238380390 NA 0.67 11.84 0.54 3e-27 Prostate cancer; LUSC cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg09904177 chr6:26538194 HMGN4 -0.5 -7.86 -0.39 5.42e-14 Schizophrenia; LUSC cis rs6121246 0.567 rs6060344 chr20:30207316 A/G cg21427119 chr20:30132790 HM13 -0.43 -6.19 -0.32 1.77e-9 Mean corpuscular hemoglobin; LUSC cis rs1018836 0.828 rs4735236 chr8:91583909 A/G cg16814680 chr8:91681699 NA -0.69 -10.91 -0.51 6.53e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg23791538 chr6:167370224 RNASET2 -0.41 -6.63 -0.34 1.32e-10 Crohn's disease; LUSC trans rs9929218 0.861 rs3114409 chr16:68732049 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -13.19 -0.59 2.98e-32 Colorectal cancer; LUSC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg02569458 chr12:86230093 RASSF9 0.58 9.9 0.48 1.97e-20 Major depressive disorder; LUSC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg06634786 chr22:41940651 POLR3H -0.51 -6.27 -0.32 1.14e-9 Vitiligo; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14312959 chr17:79008933 FLJ90757;BAIAP2 -0.48 -6.04 -0.31 4.09e-9 Bipolar disorder and schizophrenia; LUSC cis rs4808199 0.895 rs10403731 chr19:19469296 G/A cg03709012 chr19:19516395 GATAD2A 1.06 13.11 0.58 6.04e-32 Nonalcoholic fatty liver disease; LUSC trans rs12310956 0.510 rs10743832 chr12:33884146 A/C cg26384229 chr12:38710491 ALG10B 0.55 8.48 0.42 7.29e-16 Morning vs. evening chronotype; LUSC cis rs950169 0.922 rs2033284 chr15:84946273 C/T cg17507749 chr15:85114479 UBE2QP1 0.66 8.29 0.41 2.85e-15 Schizophrenia; LUSC cis rs2073300 0.609 rs6132617 chr20:23420151 G/C cg12062639 chr20:23401060 NAPB 0.94 8.06 0.4 1.33e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg19592336 chr6:28129416 ZNF389 0.45 5.81 0.3 1.46e-8 Depression; LUSC cis rs7572644 0.713 rs11127127 chr2:28066904 G/T cg27432699 chr2:27873401 GPN1 0.53 6.79 0.35 5.07e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1577917 0.958 rs12207374 chr6:86656645 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.65 -0.34 1.21e-10 Response to antipsychotic treatment; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs2637266 0.967 rs7477607 chr10:78358768 G/T cg18941641 chr10:78392320 NA 0.38 7.01 0.36 1.35e-11 Pulmonary function; LUSC cis rs7191439 0.858 rs7205626 chr16:88780472 T/C cg27087555 chr16:88793112 FAM38A -1.38 -13.78 -0.6 1.66e-34 Plateletcrit; LUSC trans rs2243480 0.706 rs6460257 chr7:65196780 C/T cg10756647 chr7:56101905 PSPH 0.83 9.4 0.46 8.92e-19 Diabetic kidney disease; LUSC cis rs4853525 0.859 rs1882396 chr2:191716012 T/G cg11845111 chr2:191398756 TMEM194B -0.42 -6.18 -0.32 1.91e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs78707713 0.512 rs12772559 chr10:71184356 C/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.65 -0.47 1.34e-19 Venous thromboembolism; LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg05347473 chr6:146136440 FBXO30 0.51 8.31 0.41 2.46e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 6.05 0.31 3.93e-9 Tonsillectomy; LUSC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg18230493 chr5:56204884 C5orf35 0.58 9.2 0.45 3.92e-18 Coronary artery disease; LUSC cis rs11030122 0.702 rs12223176 chr11:3982537 T/G cg18678763 chr11:4115507 RRM1 -0.47 -6.0 -0.31 5.25e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.57 -8.65 -0.43 2.21e-16 Lymphocyte counts; LUSC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2281845 0.507 rs11589642 chr1:201100748 A/G cg22815214 chr1:201083145 CACNA1S -0.43 -5.88 -0.31 9.71e-9 Permanent tooth development; LUSC cis rs57590327 0.555 rs3755713 chr3:81811224 A/G cg07356753 chr3:81810745 GBE1 -0.67 -10.25 -0.49 1.26e-21 Extraversion; LUSC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg12927641 chr6:109611667 NA 0.43 7.41 0.38 1.05e-12 Reticulocyte fraction of red cells; LUSC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.11e-16 Schizophrenia; LUSC cis rs4499344 0.623 rs259278 chr19:33161126 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.97 16.49 0.67 4.1e-45 Mean platelet volume; LUSC cis rs8092503 1.000 rs2014237 chr18:52494583 T/C cg12377874 chr18:52495404 RAB27B -0.34 -6.18 -0.32 1.9e-9 Childhood body mass index; LUSC cis rs17253792 0.822 rs58589065 chr14:56152478 T/C cg01858014 chr14:56050164 KTN1 -0.75 -6.59 -0.34 1.7e-10 Putamen volume; LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.49 0.42 6.97e-16 Prudent dietary pattern; LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs796364 0.806 rs10445792 chr2:201078821 A/C cg23649088 chr2:200775458 C2orf69 -0.55 -6.52 -0.34 2.6e-10 Schizophrenia; LUSC cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg00277334 chr10:82204260 NA -0.95 -20.09 -0.74 2e-59 Post bronchodilator FEV1; LUSC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg12310025 chr6:25882481 NA -0.58 -9.59 -0.46 2.11e-19 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1728785 1.000 rs1728784 chr16:68591156 T/A cg02972257 chr16:68554789 NA -0.53 -6.76 -0.35 6.31e-11 Ulcerative colitis; LUSC cis rs113835537 0.569 rs17496586 chr11:66315512 G/C cg24851651 chr11:66362959 CCS 0.51 7.41 0.38 1.03e-12 Airway imaging phenotypes; LUSC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg21963583 chr11:68658836 MRPL21 0.58 9.11 0.45 7.56e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7772486 0.875 rs932522 chr6:146374026 A/G cg05347473 chr6:146136440 FBXO30 -0.49 -7.85 -0.39 5.73e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9818941 0.824 rs2712325 chr3:157787473 G/C cg08654915 chr3:157813417 NA -0.34 -7.86 -0.4 5.32e-14 Height; LUSC cis rs9788682 1.000 rs35212593 chr15:78831826 G/A cg06917634 chr15:78832804 PSMA4 -0.59 -7.17 -0.37 4.74e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11792861 0.781 rs11793272 chr9:111762102 G/A cg13535736 chr9:111863775 C9orf5 -0.41 -6.51 -0.34 2.72e-10 Menarche (age at onset); LUSC cis rs11048434 0.736 rs1049925 chr12:9086898 A/G cg13575925 chr12:9217583 LOC144571 0.32 5.8 0.3 1.53e-8 Sjögren's syndrome; LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.39 0.53 1.28e-25 Prudent dietary pattern; LUSC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg17264618 chr3:40429014 ENTPD3 -0.33 -7.28 -0.37 2.4e-12 Renal cell carcinoma; LUSC cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg23711669 chr6:146136114 FBXO30 0.92 17.7 0.7 6.72e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs4308124 0.708 rs28766030 chr2:111962429 T/C cg04571233 chr2:111982156 NA -0.5 -6.55 -0.34 2.11e-10 Vitiligo; LUSC cis rs911119 0.913 rs12710327 chr20:23569689 C/T cg16589663 chr20:23618590 CST3 0.62 7.35 0.37 1.54e-12 Chronic kidney disease; LUSC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC trans rs2980439 0.846 rs2980437 chr8:8094763 C/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.28 -0.32 1.05e-9 Neuroticism; LUSC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg08499158 chr17:42289980 UBTF -0.49 -8.31 -0.41 2.46e-15 Total body bone mineral density; LUSC cis rs9811920 0.809 rs4928151 chr3:99767553 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -7.0 -0.36 1.45e-11 Axial length; LUSC cis rs11997175 0.546 rs1561913 chr8:33587002 A/T ch.8.33884649F chr8:33765107 NA 0.49 7.75 0.39 1.14e-13 Body mass index; LUSC cis rs3820928 1.000 rs10204368 chr2:227774244 G/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.85 -0.39 5.89e-14 Pulmonary function; LUSC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.87 0.44 4.57e-17 Menopause (age at onset); LUSC cis rs3774830 0.748 rs7698146 chr4:5465476 G/A cg26943120 chr4:5472116 STK32B 0.29 5.78 0.3 1.68e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9905704 0.708 rs304263 chr17:56749941 C/T cg12560992 chr17:57184187 TRIM37 0.57 8.37 0.42 1.58e-15 Testicular germ cell tumor; LUSC cis rs9818758 0.607 rs11716445 chr3:49406095 C/T cg00383909 chr3:49044727 WDR6 1.44 10.13 0.48 3.33e-21 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs7100689 0.753 rs1572816 chr10:82137600 A/G cg01528321 chr10:82214614 TSPAN14 1.03 16.28 0.67 2.76e-44 Post bronchodilator FEV1; LUSC cis rs5009270 0.512 rs6977807 chr7:112249863 C/T cg27282281 chr7:112262583 NA 0.44 6.04 0.31 4.07e-9 Osteoarthritis (hip); LUSC cis rs7512552 0.839 rs7523428 chr1:150430472 G/A cg15654264 chr1:150340011 RPRD2 0.65 10.77 0.51 1.97e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9486715 0.830 rs4425602 chr6:96893906 G/A cg06623918 chr6:96969491 KIAA0776 0.93 17.47 0.69 5.11e-49 Headache; LUSC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.03 15.77 0.65 2.97e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.86e-9 Major depressive disorder; LUSC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg12311346 chr5:56204834 C5orf35 -0.61 -9.45 -0.46 6.26e-19 Breast cancer;Breast cancer (early onset); LUSC cis rs559928 0.606 rs57021319 chr11:63956102 G/A cg24687543 chr11:63912206 MACROD1 0.46 5.73 0.3 2.24e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg00933542 chr6:150070202 PCMT1 0.28 5.74 0.3 2.08e-8 Lung cancer; LUSC cis rs3862435 0.764 rs2283444 chr15:91002201 G/A cg22089800 chr15:90895588 ZNF774 0.55 5.72 0.3 2.42e-8 Response to exercise (triglyceride level interaction); LUSC cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs61931739 0.500 rs7955247 chr12:34126580 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.41 0.53 1.09e-25 Morning vs. evening chronotype; LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg10360139 chr7:1886902 MAD1L1 -0.44 -6.91 -0.35 2.42e-11 Bipolar disorder and schizophrenia; LUSC cis rs9549367 0.789 rs12584981 chr13:113881185 T/C cg18105134 chr13:113819100 PROZ -0.67 -9.41 -0.46 8.43e-19 Platelet distribution width; LUSC cis rs10435719 0.764 rs10103485 chr8:11787563 C/T cg21775007 chr8:11205619 TDH 0.49 7.06 0.36 9.95e-12 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg08213375 chr14:104286397 PPP1R13B 0.44 8.11 0.41 9.52e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11608355 0.597 rs12579285 chr12:109832712 T/C cg19025524 chr12:109796872 NA -0.46 -8.8 -0.43 7.27e-17 Neuroticism; LUSC cis rs7597155 0.811 rs11126245 chr2:69975000 C/T cg02498382 chr2:70120550 SNRNP27 -0.24 -5.77 -0.3 1.83e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg09509183 chr1:209979624 IRF6 0.48 5.78 0.3 1.7e-8 Cleft lip with or without cleft palate; LUSC cis rs17270561 0.636 rs9358880 chr6:25743161 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.73 0.39 1.29e-13 Iron status biomarkers; LUSC cis rs11098499 0.662 rs13108589 chr4:120268102 G/C cg09307838 chr4:120376055 NA 0.7 10.47 0.5 2.23e-22 Corneal astigmatism; LUSC cis rs6005807 0.719 rs12166475 chr22:28860167 T/G cg12565055 chr22:29076175 TTC28 0.57 5.93 0.31 7.42e-9 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs694739 0.964 rs2510066 chr11:64052447 C/T cg23796481 chr11:64053134 BAD;GPR137 0.61 9.72 0.47 7.75e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg22508957 chr16:3507546 NAT15 0.42 5.99 0.31 5.34e-9 Body mass index (adult); LUSC cis rs10875746 0.855 rs10875731 chr12:48432743 G/A cg13454099 chr12:49076203 C12orf41 -0.5 -5.65 -0.3 3.48e-8 Longevity (90 years and older); LUSC cis rs8060686 0.545 rs12597573 chr16:68167521 A/C cg04539111 chr16:67997858 SLC12A4 0.46 5.67 0.3 3.12e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs9359856 0.623 rs7742602 chr6:90327385 A/G cg13799429 chr6:90582589 CASP8AP2 -0.83 -10.29 -0.49 9.05e-22 Bipolar disorder; LUSC cis rs965469 0.843 rs6037597 chr20:3408374 A/G cg25506879 chr20:3388711 C20orf194 -0.51 -6.04 -0.31 4.18e-9 IFN-related cytopenia; LUSC cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.35 0.33 7.18e-10 Rheumatoid arthritis; LUSC cis rs7216064 0.953 rs62086043 chr17:65968003 A/G cg12091567 chr17:66097778 LOC651250 -0.68 -9.13 -0.45 6.75e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg26380479 chr7:97908229 NA -0.27 -6.14 -0.32 2.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg17178900 chr1:205818956 PM20D1 0.81 13.49 0.59 2.08e-33 Menarche (age at onset); LUSC cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg04998671 chr14:104000505 TRMT61A -0.39 -5.72 -0.3 2.42e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs4073416 0.542 rs2411820 chr14:65946744 C/T cg03016385 chr14:66212404 NA -0.39 -5.97 -0.31 6.05e-9 N-glycan levels; LUSC cis rs1107366 0.722 rs9851577 chr3:125908310 C/T cg01346077 chr3:125931526 NA 0.35 6.58 0.34 1.84e-10 Metabolite levels; LUSC cis rs4629180 1.000 rs4629180 chr2:102088370 G/A cg01388757 chr2:102091195 RFX8 -0.45 -7.1 -0.36 7.61e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs17092148 1.000 rs57131731 chr20:33392739 C/T cg16810054 chr20:33298113 TP53INP2 0.43 6.81 0.35 4.68e-11 Neuroticism; LUSC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg20811857 chr17:78079795 GAA 0.37 6.39 0.33 5.54e-10 Yeast infection; LUSC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg14552801 chr7:65878734 NA -0.45 -6.48 -0.33 3.25e-10 Aortic root size; LUSC cis rs7223966 1.000 rs8064261 chr17:61705212 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.81 0.35 4.68e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1577917 0.655 rs2842600 chr6:86325632 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.37 -5.92 -0.31 8.1e-9 Response to antipsychotic treatment; LUSC cis rs45535039 0.506 rs2511856 chr11:119144148 A/C cg16724696 chr11:118992527 HINFP -0.52 -7.15 -0.36 5.47e-12 Plateletcrit; LUSC cis rs11105298 0.891 rs8181784 chr12:89828591 A/G cg00757033 chr12:89920650 WDR51B 0.51 8.93 0.44 3.01e-17 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.45 0.38 8.31e-13 Colorectal cancer; LUSC cis rs1185460 0.967 rs1784460 chr11:118938371 A/T cg23280166 chr11:118938394 VPS11 -0.48 -7.72 -0.39 1.33e-13 Coronary artery disease; LUSC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg16339924 chr4:17578868 LAP3 0.49 7.53 0.38 4.83e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.04 0.58 1.07e-31 Chronic sinus infection; LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.39 0.67 1.04e-44 Platelet count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12165782 chr19:1675947 NA -0.42 -6.01 -0.31 4.88e-9 Bipolar disorder and schizophrenia; LUSC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg02772935 chr3:125709198 NA -0.49 -5.92 -0.31 7.84e-9 Blood pressure (smoking interaction); LUSC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg02574844 chr11:5959923 NA -0.41 -6.34 -0.33 7.42e-10 DNA methylation (variation); LUSC cis rs9921338 0.887 rs6498183 chr16:11430908 C/T cg00044050 chr16:11439710 C16orf75 -0.51 -6.78 -0.35 5.47e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg23649088 chr2:200775458 C2orf69 0.53 7.23 0.37 3.26e-12 Schizophrenia; LUSC cis rs892961 1.000 rs2117924 chr17:75401310 C/T cg05865280 chr17:75406074 SEPT9 0.47 10.38 0.49 4.45e-22 Airflow obstruction; LUSC cis rs2295359 0.892 rs10789224 chr1:67605134 C/T cg17031739 chr1:67600172 NA -0.46 -7.27 -0.37 2.51e-12 Psoriasis; LUSC cis rs952623 0.649 rs6462887 chr7:39067636 A/G cg15212455 chr7:39170539 POU6F2 0.37 6.04 0.31 4.14e-9 Intelligence (multi-trait analysis); LUSC cis rs57590327 0.612 rs820272 chr3:81554345 T/C cg07356753 chr3:81810745 GBE1 0.48 5.95 0.31 6.82e-9 Extraversion; LUSC cis rs877282 0.853 rs7092652 chr10:756109 G/A cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs28647808 0.881 rs4962047 chr9:136262916 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs2274273 0.840 rs2341622 chr14:55737243 C/A cg04306507 chr14:55594613 LGALS3 0.56 13.2 0.59 2.66e-32 Protein biomarker; LUSC cis rs308403 0.600 rs309364 chr4:123658859 A/G cg10495464 chr4:123653540 BBS12;LOC729338 -0.77 -10.59 -0.5 8.73e-23 Blood protein levels; LUSC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg14552801 chr7:65878734 NA 0.43 5.89 0.31 9.32e-9 Aortic root size; LUSC cis rs5167 0.677 rs12709889 chr19:45453239 A/G cg25746394 chr19:45450501 APOC2 -0.31 -5.94 -0.31 7.27e-9 Blood protein levels; LUSC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.37 -0.33 6.13e-10 Total body bone mineral density; LUSC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.69 -11.54 -0.53 3.77e-26 Systemic lupus erythematosus; LUSC cis rs5009270 0.512 rs1024411 chr7:112247692 G/A cg27282281 chr7:112262583 NA 0.44 5.96 0.31 6.49e-9 Osteoarthritis (hip); LUSC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg08439880 chr3:133502540 NA 0.38 6.68 0.34 9.95e-11 Iron status biomarkers; LUSC cis rs34779708 0.966 rs1545757 chr10:35445588 A/T cg04310649 chr10:35416472 CREM -0.42 -6.45 -0.33 3.9e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg20302533 chr7:39170763 POU6F2 0.48 7.73 0.39 1.25e-13 IgG glycosylation; LUSC cis rs12908161 0.959 rs35557864 chr15:85331629 A/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.5 0.34 2.86e-10 Schizophrenia; LUSC trans rs2898290 0.694 rs2248909 chr8:11392093 A/C cg15556689 chr8:8085844 FLJ10661 -0.6 -9.57 -0.46 2.5e-19 Systolic blood pressure; LUSC cis rs7771547 0.605 rs659726 chr6:36467791 C/G cg07856975 chr6:36356162 ETV7 0.38 6.65 0.34 1.2e-10 Platelet distribution width; LUSC cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg00579200 chr11:133705235 NA 0.4 5.86 0.31 1.13e-8 Childhood ear infection; LUSC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg09998033 chr7:158218633 PTPRN2 -0.6 -9.67 -0.47 1.16e-19 Obesity-related traits; LUSC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg04450456 chr4:17643702 FAM184B 0.35 5.8 0.3 1.56e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg14893161 chr1:205819251 PM20D1 0.92 18.2 0.71 6.58e-52 Menarche (age at onset); LUSC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.4e-8 Intelligence (multi-trait analysis); LUSC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.65 10.24 0.49 1.35e-21 Menarche (age at onset); LUSC cis rs7572733 0.534 rs700684 chr2:198713099 C/T cg00792783 chr2:198669748 PLCL1 0.43 5.87 0.31 1.04e-8 Dermatomyositis; LUSC trans rs3942852 0.910 rs11603850 chr11:48140900 G/A cg15704280 chr7:45808275 SEPT13 -0.56 -6.38 -0.33 6.07e-10 Acute lymphoblastic leukemia (childhood); LUSC trans rs12210905 0.925 rs7740207 chr6:27001623 C/T cg11837749 chr1:55047332 ACOT11 0.56 6.07 0.32 3.42e-9 Hip circumference adjusted for BMI; LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg18765753 chr7:1198926 ZFAND2A -0.41 -7.51 -0.38 5.49e-13 Longevity;Endometriosis; LUSC trans rs61931739 0.635 rs4442626 chr12:33912530 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.75 0.39 1.1e-13 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15076191 chr7:75677508 STYXL1;MDH2 -0.4 -5.97 -0.31 6.15e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg17968037 chr7:100024898 ZCWPW1 -0.4 -5.75 -0.3 2.02e-8 Platelet count; LUSC cis rs66887589 0.807 rs7694483 chr4:120405929 T/A cg09307838 chr4:120376055 NA 0.46 6.92 0.35 2.25e-11 Diastolic blood pressure; LUSC cis rs983392 0.631 rs7107627 chr11:60041296 T/A cg20284999 chr11:59952153 MS4A6A 0.39 6.43 0.33 4.45e-10 Alzheimer's disease (late onset); LUSC cis rs56283067 0.847 rs1552196 chr6:44698265 A/G cg18551225 chr6:44695536 NA 0.39 6.4 0.33 5.35e-10 Total body bone mineral density; LUSC cis rs7131987 0.650 rs7973786 chr12:29462744 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.63 -0.34 1.38e-10 QT interval; LUSC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg01579765 chr21:45077557 HSF2BP -0.52 -10.8 -0.51 1.6e-23 Mean corpuscular volume; LUSC trans rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.74 -13.47 -0.59 2.5e-33 Brugada syndrome; LUSC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg16447950 chr5:562315 NA 0.52 9.1 0.45 8.36e-18 Obesity-related traits; LUSC cis rs67366981 1.000 rs17105547 chr14:77698358 G/A cg22824376 chr14:77648248 TMEM63C 0.82 7.49 0.38 6.41e-13 Obsessive-compulsive symptoms; LUSC cis rs10744422 1.000 rs1532835 chr12:123330665 G/A cg25930673 chr12:123319894 HIP1R -0.72 -7.27 -0.37 2.57e-12 Schizophrenia; LUSC cis rs1021993 0.597 rs17014320 chr1:209512173 T/C cg24446417 chr1:209558027 NA -0.35 -5.73 -0.3 2.25e-8 Gut microbiome composition (winter); LUSC trans rs2739330 0.685 rs4822453 chr22:24254862 G/T cg06437703 chr8:37914619 EIF4EBP1 -0.56 -8.98 -0.44 2.05e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.74 0.65 3.9e-42 Bladder cancer; LUSC cis rs7824557 0.591 rs2736282 chr8:11225480 C/T cg21775007 chr8:11205619 TDH 0.71 11.53 0.53 3.92e-26 Retinal vascular caliber; LUSC cis rs3092073 0.603 rs4810477 chr20:44544654 C/T cg17986701 chr20:44574422 PCIF1 0.37 6.55 0.34 2.22e-10 Intelligence (multi-trait analysis); LUSC cis rs2063714 0.967 rs9322586 chr6:157195220 T/C cg23222435 chr6:157204239 ARID1B -0.49 -7.92 -0.4 3.55e-14 Sitting height ratio; LUSC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.68 -0.39 1.83e-13 Height; LUSC cis rs9790314 0.905 rs6441370 chr3:160993754 C/T cg03342759 chr3:160939853 NMD3 -0.52 -8.72 -0.43 1.29e-16 Morning vs. evening chronotype; LUSC cis rs4561483 0.583 rs11645213 chr16:11942924 C/A cg08843971 chr16:11963173 GSPT1 0.39 5.95 0.31 6.85e-9 Testicular germ cell tumor; LUSC cis rs2795502 0.882 rs2744087 chr10:43340270 A/C cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs2070488 0.699 rs13064938 chr3:38440237 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.72 12.63 0.57 3.62e-30 Electrocardiographic conduction measures; LUSC cis rs950169 0.922 rs62028133 chr15:84919375 A/C cg17507749 chr15:85114479 UBE2QP1 0.67 8.58 0.43 3.57e-16 Schizophrenia; LUSC cis rs7618501 0.735 rs9876508 chr3:49780844 G/A cg13072238 chr3:49761600 GMPPB -0.4 -6.49 -0.33 3.1e-10 Intelligence (multi-trait analysis); LUSC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg16447950 chr5:562315 NA -0.58 -7.11 -0.36 7.26e-12 Obesity-related traits; LUSC cis rs1030877 0.515 rs2576742 chr2:105898822 A/T cg02079111 chr2:105885981 TGFBRAP1 0.67 9.19 0.45 4.29e-18 Obesity-related traits; LUSC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg27539214 chr16:67997921 SLC12A4 -0.58 -7.67 -0.39 1.9e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs10754283 0.967 rs2390763 chr1:90105688 A/G cg21401794 chr1:90099060 LRRC8C 0.65 9.8 0.47 4.22e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs10193935 0.901 rs222483 chr2:42652184 T/G cg27598129 chr2:42591480 NA -0.61 -8.32 -0.41 2.34e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs4930103 0.619 rs10769945 chr11:1985127 C/T cg06197492 chr11:2016605 H19 0.42 6.91 0.35 2.52e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs8114671 0.647 rs6060267 chr20:33734012 A/G cg24642439 chr20:33292090 TP53INP2 0.4 5.74 0.3 2.08e-8 Height; LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.63 0.6 6.19e-34 Platelet count; LUSC cis rs9473147 0.516 rs9395283 chr6:47551444 T/C cg02130027 chr6:47444894 CD2AP 0.35 5.76 0.3 1.92e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs10504229 0.679 rs16921687 chr8:58053514 T/C cg11062466 chr8:58055876 NA 0.51 6.7 0.34 8.73e-11 Developmental language disorder (linguistic errors); LUSC trans rs7937682 0.575 rs7127010 chr11:111770782 C/T cg18187862 chr3:45730750 SACM1L -0.51 -6.27 -0.32 1.1e-9 Primary sclerosing cholangitis; LUSC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.39 0.37 1.23e-12 Motion sickness; LUSC cis rs12594515 1.000 rs8026221 chr15:45987910 G/T cg06207120 chr15:45996521 NA 0.39 6.09 0.32 3.08e-9 Waist circumference;Weight; LUSC cis rs11122272 0.735 rs2790881 chr1:231534181 A/G cg06096015 chr1:231504339 EGLN1 0.58 10.37 0.49 5e-22 Hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26022992 chr1:145507616 RBM8A 0.42 6.05 0.31 3.84e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10791097 0.694 rs7106684 chr11:130758153 A/T cg12179176 chr11:130786555 SNX19 0.87 14.66 0.63 6.69e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs2797160 0.967 rs2747715 chr6:126007719 A/T cg05039488 chr6:79577232 IRAK1BP1 0.47 6.99 0.36 1.53e-11 Endometrial cancer; LUSC cis rs8060686 0.668 rs2418739 chr16:68092850 G/C cg26727032 chr16:67993705 SLC12A4 -0.41 -6.48 -0.33 3.21e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs747782 0.646 rs61914719 chr11:48059091 C/T cg20307385 chr11:47447363 PSMC3 -0.64 -5.64 -0.3 3.54e-8 Intraocular pressure; LUSC cis rs3755132 0.929 rs3770471 chr2:15770775 C/T cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg10802521 chr3:52805072 NEK4 -0.53 -7.61 -0.38 2.88e-13 Bipolar disorder; LUSC cis rs9807989 0.839 rs4988957 chr2:102968075 C/T cg03938978 chr2:103052716 IL18RAP -0.31 -5.72 -0.3 2.33e-8 Asthma; LUSC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg18876405 chr7:65276391 NA 0.77 13.86 0.6 8.2e-35 Aortic root size; LUSC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg18099408 chr3:52552593 STAB1 -0.41 -7.14 -0.36 5.86e-12 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.17e-9 Prudent dietary pattern; LUSC cis rs9300255 0.602 rs1569068 chr12:123632276 A/G cg00376283 chr12:123451042 ABCB9 -0.55 -7.38 -0.37 1.24e-12 Neutrophil percentage of white cells; LUSC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg12311346 chr5:56204834 C5orf35 -0.96 -14.14 -0.61 6.9e-36 Initial pursuit acceleration; LUSC cis rs765787 0.530 rs1706837 chr15:45519036 A/G cg24006582 chr15:45444508 DUOX1 -0.61 -9.01 -0.44 1.56e-17 Uric acid levels; LUSC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg11871910 chr12:69753446 YEATS4 0.61 9.0 0.44 1.72e-17 Response to diuretic therapy; LUSC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg04369109 chr6:150039330 LATS1 -0.59 -8.67 -0.43 1.84e-16 Lung cancer; LUSC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg13722127 chr7:150037890 RARRES2 0.38 5.66 0.3 3.29e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg10802521 chr3:52805072 NEK4 0.48 8.04 0.4 1.62e-14 Electroencephalogram traits; LUSC trans rs3733585 0.753 rs12500805 chr4:10017979 C/T cg26043149 chr18:55253948 FECH 0.48 7.41 0.38 1.03e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs240764 0.853 rs4461738 chr6:100977940 T/C cg09795085 chr6:101329169 ASCC3 -0.41 -5.91 -0.31 8.42e-9 Neuroticism; LUSC cis rs9625935 0.957 rs36604 chr22:30340138 C/A cg11564601 chr22:30592435 NA 0.38 5.66 0.3 3.18e-8 Tonsillectomy; LUSC cis rs2795502 0.882 rs2744095 chr10:43337949 A/T cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg08888203 chr3:10149979 C3orf24 0.57 8.06 0.4 1.33e-14 Alzheimer's disease; LUSC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg06212747 chr3:49208901 KLHDC8B 0.46 6.45 0.33 3.87e-10 Parkinson's disease; LUSC cis rs7202877 0.561 rs4888369 chr16:75307277 T/C cg03315344 chr16:75512273 CHST6 0.47 6.72 0.35 7.69e-11 Type 2 diabetes;Type 1 diabetes; LUSC cis rs10845606 1.000 rs10845605 chr12:12833468 T/C cg09462578 chr12:12878428 APOLD1 -0.53 -6.38 -0.33 6e-10 Systemic lupus erythematosus; LUSC cis rs6138458 1.000 rs7269416 chr20:24976196 T/G cg06937882 chr20:24974362 C20orf3 -0.44 -7.67 -0.39 1.89e-13 Blood protein levels; LUSC cis rs36093844 0.800 rs79276445 chr11:85587827 G/T cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs2281558 0.876 rs6107025 chr20:25279880 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.62 9.26 0.45 2.46e-18 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg09455208 chr3:40491958 NA 0.57 10.18 0.49 2.19e-21 Renal cell carcinoma; LUSC cis rs9517320 0.534 rs9556963 chr13:99157026 G/A cg20487152 chr13:99095054 FARP1 -0.43 -7.65 -0.39 2.18e-13 Longevity; LUSC trans rs6502050 0.842 rs62079996 chr17:80076862 A/G cg07393940 chr7:158741817 NA -0.37 -6.52 -0.34 2.55e-10 Life satisfaction; LUSC cis rs9815354 0.638 rs56008529 chr3:42026755 A/T cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs72781680 0.950 rs72798404 chr2:24180125 C/T cg08917208 chr2:24149416 ATAD2B 1.02 10.65 0.5 5.21e-23 Lymphocyte counts; LUSC cis rs4589502 0.588 rs12438505 chr15:67213830 C/G cg09911534 chr15:67153556 NA 0.42 5.72 0.3 2.31e-8 Lung cancer (smoking interaction); LUSC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg21770322 chr7:97807741 LMTK2 0.4 6.88 0.35 2.89e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs75920871 0.588 rs7101763 chr11:116941985 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.74 -0.35 6.96e-11 Subjective well-being; LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg01879757 chr17:41196368 BRCA1 -0.46 -7.0 -0.36 1.42e-11 Menopause (age at onset); LUSC cis rs7246657 0.943 rs13343471 chr19:37932130 A/G cg23950597 chr19:37808831 NA -0.65 -7.63 -0.39 2.41e-13 Coronary artery calcification; LUSC cis rs17092148 1.000 rs6088594 chr20:33343157 A/G cg16810054 chr20:33298113 TP53INP2 0.4 6.37 0.33 6.28e-10 Neuroticism; LUSC cis rs2274273 0.837 rs7148171 chr14:55770744 G/C cg04306507 chr14:55594613 LGALS3 0.56 13.23 0.59 2.05e-32 Protein biomarker; LUSC cis rs2354432 1.000 rs7514864 chr1:146690102 T/C cg25205988 chr1:146714368 CHD1L 1.07 12.63 0.57 3.82e-30 Mitochondrial DNA levels; LUSC cis rs55665837 1.000 rs11023227 chr11:14459087 T/C cg05501817 chr11:14380813 RRAS2 -0.41 -6.51 -0.34 2.72e-10 Vitamin D levels; LUSC cis rs9815354 0.812 rs59476821 chr3:41946481 A/G cg03022575 chr3:42003672 ULK4 0.81 8.49 0.42 6.81e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2414856 0.510 rs72756998 chr15:64609871 T/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs262150 0.714 rs2657397 chr7:158785095 C/T cg09640425 chr7:158790006 NA -0.45 -6.95 -0.36 1.91e-11 Facial morphology (factor 20); LUSC cis rs6845621 0.745 rs1914606 chr4:18851242 C/T cg12196642 chr4:18937545 NA 0.32 5.87 0.31 1.04e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9300255 0.510 rs1790086 chr12:123672518 A/G cg00376283 chr12:123451042 ABCB9 0.66 8.29 0.41 2.81e-15 Neutrophil percentage of white cells; LUSC cis rs11931598 0.511 rs4689576 chr4:7025523 T/C cg02503808 chr4:7069936 GRPEL1 0.45 6.51 0.34 2.77e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs1419980 0.673 rs12366473 chr12:7728270 G/C cg10578777 chr12:7781093 NA 0.56 6.11 0.32 2.82e-9 HDL cholesterol levels; LUSC cis rs7520050 0.807 rs4274104 chr1:46217941 T/C cg06784218 chr1:46089804 CCDC17 0.3 5.95 0.31 6.92e-9 Red blood cell count;Reticulocyte count; LUSC trans rs7939886 0.920 rs12226441 chr11:55867822 G/A cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg14196790 chr5:131705035 SLC22A5 0.42 7.12 0.36 6.49e-12 Blood metabolite levels; LUSC cis rs6906287 0.647 rs11153752 chr6:118834771 A/T cg21191810 chr6:118973309 C6orf204 0.32 5.83 0.3 1.27e-8 Electrocardiographic conduction measures; LUSC cis rs9513627 1.000 rs7322368 chr13:100213990 T/C cg25919922 chr13:100150906 NA 0.83 6.62 0.34 1.39e-10 Obesity-related traits; LUSC cis rs10911251 0.546 rs12034436 chr1:183114797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.68 10.39 0.49 4.22e-22 Colorectal cancer; LUSC cis rs7091068 0.706 rs620043 chr10:95405257 T/C cg20715218 chr10:95462985 C10orf4 -0.6 -6.09 -0.32 3.15e-9 Urinary tract infection frequency; LUSC cis rs1577917 1.000 rs35797755 chr6:86706554 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.57 -0.34 1.94e-10 Response to antipsychotic treatment; LUSC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs752010 0.695 rs10789407 chr1:42106538 G/T cg06885757 chr1:42089581 HIVEP3 0.44 8.59 0.43 3.36e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg04398451 chr17:18023971 MYO15A 0.66 11.12 0.52 1.15e-24 Total body bone mineral density; LUSC cis rs2607426 0.581 rs2545763 chr19:41307170 G/A cg05508168 chr19:41255947 C19orf54;SNRPA 0.95 6.43 0.33 4.35e-10 Blood protein levels; LUSC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs763121 0.819 rs5757126 chr22:38923675 T/C cg06022373 chr22:39101656 GTPBP1 0.78 11.75 0.54 6.68e-27 Menopause (age at onset); LUSC cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg08847533 chr14:75593920 NEK9 -0.83 -15.44 -0.65 5.86e-41 Height; LUSC cis rs1712517 0.771 rs10883858 chr10:105127708 G/A cg05636881 chr10:105038444 INA 0.4 6.74 0.35 7.02e-11 Migraine; LUSC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg12463550 chr7:65579703 CRCP -0.49 -7.02 -0.36 1.24e-11 Aortic root size; LUSC cis rs829883 0.664 rs829876 chr12:98842138 A/G cg25150519 chr12:98850993 NA 0.8 13.63 0.6 6.18e-34 Colorectal adenoma (advanced); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21008671 chr4:26322419 RBPJ -0.41 -6.06 -0.31 3.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8028313 0.630 rs28565266 chr15:67938011 C/G cg05925327 chr15:68127851 NA -0.43 -6.82 -0.35 4.18e-11 Obesity; LUSC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg00310523 chr12:86230176 RASSF9 0.51 9.65 0.47 1.33e-19 Major depressive disorder; LUSC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg18230493 chr5:56204884 C5orf35 -0.92 -13.85 -0.6 8.41e-35 Initial pursuit acceleration; LUSC cis rs3755132 0.929 rs4668454 chr2:15740128 A/C cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.68e-12 Wilms tumor; LUSC cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 6.93 0.35 2.18e-11 Height; LUSC cis rs8062405 0.824 rs7191618 chr16:28565667 C/G cg16576597 chr16:28551801 NUPR1 0.28 5.69 0.3 2.76e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.62 0.38 2.61e-13 Prudent dietary pattern; LUSC trans rs561341 0.941 rs736678 chr17:30347423 G/T cg20587970 chr11:113659929 NA -1.35 -19.08 -0.72 2.06e-55 Hip circumference adjusted for BMI; LUSC cis rs1712517 0.904 rs7905968 chr10:105135319 C/T cg05636881 chr10:105038444 INA 0.4 6.59 0.34 1.7e-10 Migraine; LUSC cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.45 0.5 2.65e-22 Bladder cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23296058 chr5:86708877 CCNH -0.49 -6.44 -0.33 4.22e-10 Bipolar disorder and schizophrenia; LUSC trans rs11992162 0.636 rs13265816 chr8:11797485 G/A cg27411982 chr8:10470053 RP1L1 0.42 6.32 0.33 8.54e-10 Monocyte count; LUSC cis rs6752107 0.837 rs3792108 chr2:234184952 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.69 11.57 0.53 3e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6494488 0.500 rs67533952 chr15:65024574 G/C cg08069370 chr15:64387884 SNX1 -0.61 -5.76 -0.3 1.92e-8 Coronary artery disease; LUSC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.51 0.34 2.78e-10 Lung cancer; LUSC cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg24692254 chr21:30365293 RNF160 -0.7 -10.71 -0.51 3.27e-23 Pancreatic cancer; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg02353165 chr6:42928485 GNMT 0.68 11.84 0.54 3.07e-27 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9644630 0.897 rs13266857 chr8:19364515 C/T cg01280390 chr8:19363452 CSGALNACT1 -0.34 -5.88 -0.31 1e-8 Oropharynx cancer; LUSC cis rs7178375 0.607 rs12903674 chr15:31194552 G/C cg15020726 chr15:31196382 MTMR15 0.9 7.46 0.38 7.57e-13 Hypertriglyceridemia; LUSC cis rs6733011 0.600 rs1568213 chr2:99432063 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.79 -0.3 1.58e-8 Bipolar disorder; LUSC cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs9467773 0.565 rs4343916 chr6:26522675 A/T cg11502198 chr6:26597334 ABT1 0.75 11.72 0.54 8.53e-27 Intelligence (multi-trait analysis); LUSC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -17.32 -0.69 2.1e-48 Coronary artery disease; LUSC cis rs394563 0.591 rs11155641 chr6:149648595 G/A cg07828024 chr6:149772892 ZC3H12D 0.33 6.92 0.35 2.27e-11 Dupuytren's disease; LUSC cis rs61931739 0.534 rs11053020 chr12:34111092 C/G cg06521331 chr12:34319734 NA -0.47 -7.66 -0.39 2.08e-13 Morning vs. evening chronotype; LUSC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.09 -0.36 8.12e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10911232 0.524 rs10911229 chr1:183050368 C/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Hypertriglyceridemia; LUSC cis rs250677 0.524 rs40521 chr5:148439639 C/T cg18129178 chr5:148520854 ABLIM3 0.57 9.73 0.47 7.22e-20 Breast cancer; LUSC cis rs10887741 0.606 rs3824722 chr10:89435723 C/G cg13926569 chr10:89418898 PAPSS2 0.32 6.86 0.35 3.27e-11 Exercise (leisure time); LUSC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.3 -6.0 -0.31 5.09e-9 Lymphocyte counts; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.77 0.39 9.93e-14 Lymphocyte counts; LUSC cis rs6500602 0.702 rs3761680 chr16:4524060 C/A cg08645402 chr16:4508243 NA 0.55 9.44 0.46 6.49e-19 Schizophrenia; LUSC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg03806693 chr22:41940476 POLR3H 0.98 13.57 0.6 1.03e-33 Vitiligo; LUSC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg16479474 chr6:28041457 NA 0.31 5.76 0.3 1.88e-8 Parkinson's disease; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg24101359 chr6:42928495 GNMT 0.38 6.35 0.33 6.9e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs727505 0.954 rs67870530 chr7:124591878 A/G cg23710748 chr7:124431027 NA -0.39 -6.9 -0.35 2.56e-11 Lewy body disease; LUSC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg06238570 chr21:40685208 BRWD1 -0.59 -9.38 -0.46 1.06e-18 Menarche (age at onset); LUSC cis rs11098499 0.690 rs34818745 chr4:120257055 T/C cg24375607 chr4:120327624 NA 0.79 11.95 0.55 1.24e-27 Corneal astigmatism; LUSC cis rs9549260 0.755 rs2701869 chr13:41157372 G/A cg21288729 chr13:41239152 FOXO1 0.61 9.43 0.46 7.1e-19 Red blood cell count; LUSC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg05535760 chr7:792225 HEATR2 0.81 9.45 0.46 6.31e-19 Cerebrospinal P-tau181p levels; LUSC cis rs3768617 0.510 rs12086466 chr1:183075778 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.73 -11.22 -0.52 5.11e-25 Fuchs's corneal dystrophy; LUSC cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg22681709 chr2:178499509 PDE11A -0.51 -9.14 -0.45 6.4e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg20476274 chr7:133979776 SLC35B4 0.79 13.87 0.6 7.39e-35 Mean platelet volume; LUSC cis rs34891900 0.507 rs12167771 chr22:18124332 G/A cg19898043 chr22:18121309 BCL2L13 0.41 6.26 0.32 1.18e-9 Sum neutrophil eosinophil counts; LUSC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg18512352 chr11:47633146 NA -0.46 -9.47 -0.46 5.09e-19 Subjective well-being; LUSC cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.49 -0.33 3.14e-10 Monocyte percentage of white cells; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg04944784 chr2:26401820 FAM59B -0.72 -10.74 -0.51 2.55e-23 Gut microbiome composition (summer); LUSC cis rs782590 0.764 rs2586970 chr2:55829967 A/G cg18811423 chr2:55921094 PNPT1 0.77 12.76 0.57 1.2e-30 Metabolic syndrome; LUSC cis rs73200209 0.744 rs41452748 chr12:116509432 A/T cg01776926 chr12:116560359 MED13L -0.49 -5.92 -0.31 7.8e-9 Total body bone mineral density; LUSC cis rs3106136 0.546 rs2276910 chr4:95129238 T/C cg11021082 chr4:95130006 SMARCAD1 -0.39 -6.71 -0.34 8.37e-11 Capecitabine sensitivity; LUSC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg18135555 chr8:22132992 PIWIL2 0.38 7.65 0.39 2.17e-13 Hypertriglyceridemia; LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg20607798 chr8:58055168 NA 0.53 5.78 0.3 1.73e-8 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg21782813 chr7:2030301 MAD1L1 0.43 7.28 0.37 2.41e-12 Bipolar disorder and schizophrenia; LUSC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg23978390 chr7:1156363 C7orf50 0.5 5.8 0.3 1.57e-8 Bronchopulmonary dysplasia; LUSC cis rs3771570 1.000 rs17386555 chr2:242371825 G/A cg21155796 chr2:242212141 HDLBP 0.61 6.67 0.34 1.05e-10 Prostate cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg11835582 chr4:175205044 FBXO8;KIAA1712 0.42 6.79 0.35 5.28e-11 Triglycerides; LUSC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg08847533 chr14:75593920 NEK9 0.84 15.27 0.64 2.63e-40 Height; LUSC cis rs7937682 0.889 rs564086 chr11:111501079 C/G cg09085632 chr11:111637200 PPP2R1B -1.11 -17.78 -0.7 3.02e-50 Primary sclerosing cholangitis; LUSC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg09165964 chr15:75287851 SCAMP5 1.1 16.06 0.66 2.03e-43 Blood trace element (Zn levels); LUSC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.79 0.3 1.64e-8 Menopause (age at onset); LUSC cis rs9300255 0.602 rs1626899 chr12:123708063 A/G cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs7586879 0.521 rs1865689 chr2:25108197 C/T cg04586622 chr2:25135609 ADCY3 -0.39 -8.12 -0.41 8.8e-15 Body mass index; LUSC cis rs2204008 0.515 rs11495471 chr12:38027178 G/A cg13010199 chr12:38710504 ALG10B 0.71 10.93 0.51 5.63e-24 Bladder cancer; LUSC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4076764 0.846 rs4255362 chr1:163424630 G/A cg24596788 chr1:163392923 NA -0.4 -6.88 -0.35 2.9100000000000002e-11 Motion sickness; LUSC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.07 0.36 9.07e-12 Schizophrenia; LUSC cis rs61935443 0.832 rs11107768 chr12:95274182 A/T cg21533806 chr12:95267307 NA -0.55 -6.99 -0.36 1.48e-11 Schizophrenia; LUSC cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -12.22 -0.56 1.23e-28 Chronic sinus infection; LUSC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.12 0.36 6.48e-12 Blood metabolite levels; LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg18404041 chr3:52824283 ITIH1 -0.46 -8.23 -0.41 4.26e-15 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg25703541 chr22:24373054 LOC391322 -0.87 -14.04 -0.61 1.57e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11958404 0.932 rs56065211 chr5:157439386 C/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg21862992 chr11:68658383 NA -0.51 -8.18 -0.41 5.99e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7100689 0.646 rs7077854 chr10:82124070 C/T cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC trans rs7713972 0.588 rs13181692 chr5:40607998 A/G cg01842719 chr2:241658550 KIF1A 0.46 6.02 0.31 4.67e-9 Blood protein levels; LUSC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg24562669 chr7:97807699 LMTK2 0.36 6.27 0.32 1.15e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg10909506 chr17:38081995 ORMDL3 0.34 6.15 0.32 2.26e-9 Self-reported allergy; LUSC cis rs7264396 0.635 rs6060710 chr20:34536055 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.42 -0.46 7.56e-19 Total cholesterol levels; LUSC cis rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10397063 chr6:136611015 BCLAF1 -0.4 -5.99 -0.31 5.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg25319279 chr11:5960081 NA -0.45 -6.41 -0.33 4.99e-10 DNA methylation (variation); LUSC cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg01973587 chr1:228161476 NA 0.47 8.55 0.42 4.63e-16 Diastolic blood pressure; LUSC cis rs9341835 0.772 rs4445042 chr6:64139997 C/T cg03326410 chr6:64151739 NA -0.36 -5.79 -0.3 1.6e-8 Schizophrenia; LUSC cis rs2073300 1.000 rs6132626 chr20:23444672 T/C cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg22681709 chr2:178499509 PDE11A -0.6 -11.81 -0.54 3.82e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs10221833 0.602 rs355882 chr2:165633761 T/C cg26993132 chr16:89239499 CDH15 0.31 5.97 0.31 6.09e-9 Response to statin therapy; LUSC trans rs853679 0.517 rs9366715 chr6:28064633 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.17 -0.32 1.99e-9 Depression; LUSC cis rs6964587 1.000 rs6951972 chr7:91689446 T/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.02e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs9650657 0.513 rs7005884 chr8:10796472 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.57 -0.38 3.74e-13 Neuroticism; LUSC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Parkinson's disease; LUSC trans rs1814175 0.645 rs28538913 chr11:50040718 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs11608355 0.515 rs11613718 chr12:109912332 C/T cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.85 -0.44 5.26e-17 Gut microbiome composition (summer); LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg11645453 chr3:52864694 ITIH4 0.35 8.43 0.42 1.08e-15 Bipolar disorder; LUSC cis rs2806561 0.704 rs2746560 chr1:23526279 G/A cg19743168 chr1:23544995 NA 0.46 9.2 0.45 3.87e-18 Height; LUSC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10193935 0.681 rs13396880 chr2:42374700 G/T cg27598129 chr2:42591480 NA -0.6 -7.32 -0.37 1.83e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg21724239 chr8:58056113 NA 0.59 7.28 0.37 2.48e-12 Developmental language disorder (linguistic errors); LUSC cis rs6060717 0.610 rs2794382 chr20:34613651 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.34 -0.33 7.64e-10 Hip circumference adjusted for BMI; LUSC cis rs8017423 1.000 rs10129210 chr14:90668379 G/T cg04374321 chr14:90722782 PSMC1 0.7 10.83 0.51 1.25e-23 Mortality in heart failure; LUSC cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg00071950 chr4:10020882 SLC2A9 0.65 10.64 0.5 5.7e-23 Bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12317151 chr18:3012764 LPIN2 0.92 7.33 0.37 1.71e-12 Cognitive performance; LUSC trans rs1908814 0.516 rs13281077 chr8:11794814 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.22e-15 Neuroticism; LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg04944784 chr2:26401820 FAM59B 0.7 9.12 0.45 7.24e-18 Gut microbiome composition (summer); LUSC cis rs6920965 0.507 rs4285341 chr6:126205589 T/G cg05901451 chr6:126070800 HEY2 -0.54 -7.77 -0.39 9.45e-14 High light scatter reticulocyte count; LUSC cis rs11148252 0.669 rs4884320 chr13:53006914 T/C cg00495681 chr13:53174319 NA 0.52 7.64 0.39 2.25e-13 Lewy body disease; LUSC cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.53 8.93 0.44 2.85e-17 IgG glycosylation; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg25428297 chr7:1022841 CYP2W1 0.28 5.69 0.3 2.78e-8 Longevity;Endometriosis; LUSC cis rs11958404 0.932 rs55943686 chr5:157439591 G/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs4141404 0.851 rs8135417 chr22:31559255 G/A cg22777020 chr22:31556080 RNF185 -0.5 -6.85 -0.35 3.65e-11 Paclitaxel-induced neuropathy; LUSC cis rs425277 0.958 rs262660 chr1:2086757 A/G cg03732007 chr1:2071316 PRKCZ 0.47 7.61 0.38 2.85e-13 Height; LUSC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg05313129 chr8:58192883 C8orf71 -0.49 -6.77 -0.35 5.9e-11 Developmental language disorder (linguistic errors); LUSC cis rs6489882 0.867 rs7134391 chr12:113366691 A/G cg20102336 chr12:113376681 OAS3 0.41 6.07 0.32 3.55e-9 Chronic lymphocytic leukemia; LUSC cis rs78456975 1.000 rs11898988 chr2:1560336 G/A cg01028140 chr2:1542097 TPO -0.6 -8.23 -0.41 4.3e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs12200782 1.000 rs6456741 chr6:26617058 C/T cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs6060717 0.654 rs6060686 chr20:34512606 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.53 -0.34 2.41e-10 Hip circumference adjusted for BMI; LUSC cis rs300703 0.515 rs440617 chr2:189818 A/G cg21211680 chr2:198530 NA -0.53 -6.53 -0.34 2.39e-10 Blood protein levels; LUSC cis rs9928842 0.771 rs4888363 chr16:75277344 A/T cg09066997 chr16:75300724 BCAR1 0.5 6.66 0.34 1.1e-10 Alcoholic chronic pancreatitis; LUSC cis rs6087990 0.806 rs875041 chr20:31383530 C/T cg13636640 chr20:31349939 DNMT3B 0.92 18.96 0.72 6.33e-55 Ulcerative colitis; LUSC cis rs2281558 0.793 rs6115227 chr20:25591377 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.6 8.83 0.44 5.9e-17 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg05283184 chr6:79620031 NA -0.57 -12.12 -0.55 2.99e-28 Intelligence (multi-trait analysis); LUSC cis rs300703 0.935 rs300704 chr2:240255 A/C cg21211680 chr2:198530 NA 0.73 7.58 0.38 3.37e-13 Blood protein levels; LUSC cis rs3812049 0.784 rs6889311 chr5:127431285 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 9.13 0.45 6.54e-18 Lymphocyte counts;Red cell distribution width; LUSC trans rs4332037 0.624 rs11764337 chr7:1892309 A/G cg25206134 chr2:45395956 NA -0.5 -6.26 -0.32 1.21e-9 Bipolar disorder; LUSC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.81 -10.8 -0.51 1.64e-23 Schizophrenia; LUSC cis rs9942416 0.660 rs17649055 chr5:74984269 C/T cg19683494 chr5:74908142 NA 0.41 6.32 0.33 8.61e-10 Age-related disease endophenotypes; LUSC trans rs208520 0.661 rs1100950 chr6:66827285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -17.52 -0.69 3.22e-49 Exhaled nitric oxide output; LUSC trans rs7951105 1.000 rs976910 chr11:39247626 G/A cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg01475377 chr6:109611718 NA -0.4 -7.16 -0.36 5.27e-12 Reticulocyte fraction of red cells; LUSC cis rs9611519 0.929 rs2064560 chr22:41530040 A/G cg03806693 chr22:41940476 POLR3H -0.54 -7.42 -0.38 1.01e-12 Neuroticism; LUSC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08280861 chr8:58055591 NA 0.63 9.18 0.45 4.62e-18 Developmental language disorder (linguistic errors); LUSC cis rs3824867 0.920 rs7130693 chr11:47452321 T/C cg20307385 chr11:47447363 PSMC3 -0.65 -9.65 -0.47 1.35e-19 Mean corpuscular hemoglobin; LUSC trans rs11098499 0.866 rs12501602 chr4:120287935 A/T cg25214090 chr10:38739885 LOC399744 0.48 7.26 0.37 2.7e-12 Corneal astigmatism; LUSC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg20295408 chr7:1910781 MAD1L1 0.4 5.74 0.3 2.12e-8 Bipolar disorder and schizophrenia; LUSC cis rs2455601 0.786 rs56680262 chr11:8971555 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -7.44 -0.38 8.32e-13 Schizophrenia; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg08219700 chr8:58056026 NA 0.64 7.5 0.38 5.68e-13 Developmental language disorder (linguistic errors); LUSC trans rs11039798 0.688 rs12277029 chr11:48852833 G/T cg03929089 chr4:120376271 NA 0.72 6.77 0.35 5.71e-11 Axial length; LUSC cis rs10207060 0.771 rs4852124 chr2:240680022 C/T cg07506560 chr2:240697449 NA 0.45 7.16 0.36 5.23e-12 Obesity-related traits; LUSC trans rs804280 1.000 rs804280 chr8:11612698 G/T cg15556689 chr8:8085844 FLJ10661 0.52 7.86 0.4 5.21e-14 Myopia (pathological); LUSC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg16928487 chr17:17741425 SREBF1 0.47 9.31 0.45 1.78e-18 Total body bone mineral density; LUSC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg03709012 chr19:19516395 GATAD2A 0.84 14.34 0.62 1.1e-36 Tonsillectomy; LUSC trans rs8002861 0.619 rs9562516 chr13:44431738 T/C cg12856521 chr11:46389249 DGKZ 0.47 6.77 0.35 5.74e-11 Leprosy; LUSC cis rs8028313 0.731 rs6494678 chr15:67946247 C/T cg08079166 chr15:68083412 MAP2K5 0.33 5.78 0.3 1.74e-8 Obesity; LUSC cis rs2439831 0.867 rs2927072 chr15:43922398 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04021745 chr1:236445389 ERO1LB -0.43 -6.12 -0.32 2.62e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4654899 0.802 rs1530946 chr1:21182540 A/G cg01072550 chr1:21505969 NA 0.44 6.54 0.34 2.26e-10 Superior frontal gyrus grey matter volume; LUSC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg23711669 chr6:146136114 FBXO30 0.87 16.34 0.67 1.68e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs10779751 0.734 rs2791650 chr1:11132541 G/C cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs7122539 0.646 rs9633985 chr11:66520608 A/T cg24851651 chr11:66362959 CCS 0.47 7.58 0.38 3.43e-13 HIV-1 susceptibility; LUSC trans rs1493916 0.744 rs7504560 chr18:31312148 A/G cg27147174 chr7:100797783 AP1S1 -0.58 -9.15 -0.45 5.86e-18 Life satisfaction; LUSC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg02773041 chr1:40204384 PPIE -0.52 -7.66 -0.39 2.03e-13 Blood protein levels; LUSC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs3099143 1.000 rs10431768 chr15:77162158 A/G cg21673338 chr15:77095150 SCAPER 0.79 7.51 0.38 5.28e-13 Recalcitrant atopic dermatitis; LUSC cis rs8141797 0.901 rs5760201 chr22:24474704 A/G cg00411358 chr22:24577142 SUSD2 -0.55 -5.74 -0.3 2.09e-8 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs7799006 0.691 rs10447541 chr7:2301578 T/G cg12823233 chr7:2316876 SNX8 -0.46 -7.8 -0.39 7.86e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg06641503 chr3:48959341 ARIH2 -0.38 -5.88 -0.31 9.77e-9 Parkinson's disease; LUSC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg21951975 chr1:209979733 IRF6 0.59 8.81 0.43 6.9e-17 Cleft lip with or without cleft palate; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.66 11.04 0.52 2.22e-24 Lymphocyte counts; LUSC cis rs6504340 0.600 rs2325946 chr17:46584631 G/C cg09704116 chr17:46666958 LOC404266 0.31 5.95 0.31 6.69e-9 Primary tooth development (number of teeth); LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.84 0.3 1.22e-8 Menopause (age at onset); LUSC cis rs9790314 0.690 rs6783085 chr3:160830929 A/G cg03342759 chr3:160939853 NMD3 -0.41 -6.76 -0.35 6.14e-11 Morning vs. evening chronotype; LUSC cis rs9467711 0.591 rs35249036 chr6:26026163 C/G cg16898833 chr6:26189333 HIST1H4D 0.65 6.04 0.31 4.22e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.18 -0.32 1.84e-9 Alzheimer's disease (late onset); LUSC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg11663144 chr21:46675770 NA -0.34 -5.65 -0.3 3.51e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1499972 0.941 rs62264779 chr3:117654731 G/T cg07612923 chr3:117604196 NA 0.65 6.05 0.31 3.94e-9 Schizophrenia; LUSC cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.4 0.46 8.69e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg24250549 chr1:154909240 PMVK 0.66 11.06 0.52 2.01e-24 Prostate cancer; LUSC cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg18196295 chr10:418757 DIP2C -0.55 -9.33 -0.45 1.46e-18 Psychosis in Alzheimer's disease; LUSC cis rs738322 1.000 rs133012 chr22:38570721 G/A cg17652424 chr22:38574118 PLA2G6 -0.29 -6.45 -0.33 4e-10 Cutaneous nevi; LUSC cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg17063962 chr7:91808500 NA -0.6 -9.3 -0.45 1.87e-18 Breast cancer; LUSC cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg01849466 chr14:104193079 ZFYVE21 0.63 10.87 0.51 8.88e-24 Schizophrenia; LUSC cis rs2573652 1.000 rs2727196 chr15:100513529 C/T cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.38 -0.37 1.23e-12 Height; LUSC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7572644 0.582 rs7570730 chr2:28022675 G/A cg27432699 chr2:27873401 GPN1 0.56 7.36 0.37 1.46e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs2840044 1.000 rs9891800 chr17:33895015 G/C cg19694781 chr19:47549865 TMEM160 0.59 9.54 0.46 3.02e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.5 -0.33 2.98e-10 Colorectal cancer; LUSC cis rs96067 0.805 rs4653160 chr1:36599547 C/T cg24686825 chr1:36642396 MAP7D1 -0.42 -5.84 -0.3 1.21e-8 Corneal structure; LUSC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg06108461 chr20:60628389 TAF4 -0.97 -16.84 -0.68 1.74e-46 Body mass index; LUSC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg20503657 chr10:835505 NA 1.17 15.97 0.66 4.58e-43 Eosinophil percentage of granulocytes; LUSC cis rs79839061 0.610 rs78590562 chr4:869715 C/T cg23992470 chr4:843637 GAK 0.6 6.4 0.33 5.14e-10 Intelligence (multi-trait analysis); LUSC trans rs953492 0.624 rs4469702 chr1:243365196 T/C cg25284624 chr1:224180302 NA -0.48 -7.4 -0.38 1.12e-12 Diastolic blood pressure; LUSC cis rs17818399 0.735 rs11894342 chr2:46836439 A/T cg26688816 chr2:46740690 ATP6V1E2 -0.42 -6.21 -0.32 1.57e-9 Height; LUSC cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs72781680 0.800 rs72780112 chr2:23991182 C/T cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg15549821 chr19:49342101 PLEKHA4 -0.52 -6.09 -0.32 3.13e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg24812749 chr6:127587940 RNF146 0.81 11.76 0.54 5.83e-27 Breast cancer; LUSC cis rs9925964 0.933 rs12448321 chr16:31048280 C/T cg02466173 chr16:30829666 NA 0.36 6.57 0.34 1.91e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1784581 0.500 rs9355379 chr6:162421466 C/T cg17173639 chr6:162384350 PARK2 0.66 9.04 0.44 1.28e-17 Itch intensity from mosquito bite; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.65 10.87 0.51 9.4e-24 Lymphocyte counts; LUSC cis rs2273669 0.667 rs10457185 chr6:109322477 G/C cg05315195 chr6:109294784 ARMC2 -0.56 -6.21 -0.32 1.54e-9 Prostate cancer; LUSC cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.29e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7590720 1.000 rs4674058 chr2:216909368 A/G cg12620499 chr2:216877984 MREG 0.92 13.47 0.59 2.46e-33 Alcohol dependence; LUSC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg06640241 chr16:89574553 SPG7 0.72 11.79 0.54 4.73e-27 Multiple myeloma (IgH translocation); LUSC cis rs61931739 0.500 rs7295779 chr12:34460652 T/C cg06521331 chr12:34319734 NA -0.4 -6.53 -0.34 2.43e-10 Morning vs. evening chronotype; LUSC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg06618935 chr21:46677482 NA -0.39 -8.11 -0.41 9.92e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs17092148 1.000 rs1884432 chr20:33342439 A/G cg16810054 chr20:33298113 TP53INP2 -0.37 -5.72 -0.3 2.32e-8 Neuroticism; LUSC cis rs11587682 0.714 rs41264059 chr1:150460842 A/C cg11822372 chr1:151115635 SEMA6C -0.42 -5.71 -0.3 2.53e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7677751 0.806 rs4864862 chr4:55100489 G/A cg17187183 chr4:55093834 PDGFRA 0.39 5.84 0.3 1.25e-8 Corneal astigmatism; LUSC cis rs1023500 0.551 rs133379 chr22:42468535 A/G cg05082376 chr22:42548792 NA -0.39 -5.77 -0.3 1.77e-8 Schizophrenia; LUSC cis rs4319547 0.695 rs11057797 chr12:122860732 G/A cg23029597 chr12:123009494 RSRC2 0.75 9.5 0.46 4.15e-19 Body mass index; LUSC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg06850241 chr22:41845214 NA 0.34 6.3 0.33 9.5e-10 Vitiligo; LUSC cis rs72799341 1.000 rs7200879 chr16:30947572 A/G cg02466173 chr16:30829666 NA -0.51 -7.79 -0.39 8.48e-14 Diastolic blood pressure; LUSC cis rs11645898 0.872 rs72787093 chr16:72190766 C/T cg14768367 chr16:72042858 DHODH -0.67 -7.32 -0.37 1.82e-12 Blood protein levels; LUSC cis rs4077515 0.934 rs78428995 chr9:139281847 T/C cg14169450 chr9:139327907 INPP5E 0.43 7.6 0.38 3e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC trans rs7680126 0.586 rs7689060 chr4:10305463 C/G cg26043149 chr18:55253948 FECH 0.48 6.01 0.31 4.81e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; LUSC cis rs11122272 0.701 rs2790894 chr1:231505587 T/A cg06096015 chr1:231504339 EGLN1 0.56 9.88 0.48 2.27e-20 Hemoglobin concentration; LUSC cis rs826838 0.806 rs826873 chr12:39121305 G/A cg13010199 chr12:38710504 ALG10B -0.64 -10.96 -0.51 4.43e-24 Heart rate; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg18765753 chr7:1198926 ZFAND2A -0.36 -6.2 -0.32 1.66e-9 Longevity;Endometriosis; LUSC cis rs13401104 0.680 rs11894606 chr2:237114834 T/G cg19324714 chr2:237145437 ASB18 0.43 5.87 0.31 1.06e-8 Educational attainment; LUSC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.81 -0.35 4.57e-11 Insulin-like growth factors; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg20821713 chr7:1055600 C7orf50 -0.47 -7.58 -0.38 3.45e-13 Longevity;Endometriosis; LUSC cis rs9486715 0.867 rs9480700 chr6:96965056 A/G cg06623918 chr6:96969491 KIAA0776 0.93 17.02 0.68 3.36e-47 Headache; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.71 12.0 0.55 7.98e-28 Prudent dietary pattern; LUSC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg01097406 chr16:89675127 NA 0.3 5.69 0.3 2.85e-8 Multiple myeloma (IgH translocation); LUSC cis rs478304 0.651 rs10896037 chr11:65503424 A/G cg05805236 chr11:65401703 PCNXL3 -0.57 -9.27 -0.45 2.34e-18 Acne (severe); LUSC cis rs1023500 0.573 rs133381 chr22:42470608 C/G cg04733989 chr22:42467013 NAGA 0.62 9.62 0.47 1.73e-19 Schizophrenia; LUSC trans rs9393777 0.777 rs35984974 chr6:27410422 G/A cg06606381 chr12:133084897 FBRSL1 -0.86 -8.2 -0.41 5.37e-15 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.81 0.43 7.03e-17 Prudent dietary pattern; LUSC cis rs9296092 0.538 rs9461879 chr6:33516907 C/T cg13560919 chr6:33536144 NA -0.82 -15.66 -0.65 7.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 2.93e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg22903657 chr4:1355424 KIAA1530 -0.41 -7.17 -0.37 4.77e-12 Longevity; LUSC cis rs9300255 0.543 rs1260294 chr12:123560289 T/C cg00376283 chr12:123451042 ABCB9 -0.72 -8.23 -0.41 4.37e-15 Neutrophil percentage of white cells; LUSC cis rs3733418 0.929 rs12512234 chr4:165908865 C/T cg11630554 chr4:165878136 TRIM61;C4orf39 -0.51 -5.83 -0.3 1.34e-8 Obesity-related traits; LUSC cis rs9611565 0.649 rs738422 chr22:42123399 C/T cg03806693 chr22:41940476 POLR3H 0.86 12.69 0.57 2.2e-30 Vitiligo; LUSC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg13939156 chr17:80058883 NA -0.32 -6.37 -0.33 6.34e-10 Life satisfaction; LUSC cis rs8016982 0.674 rs11850714 chr14:81662993 C/G cg01989461 chr14:81687754 GTF2A1 0.74 13.65 0.6 4.98e-34 Schizophrenia; LUSC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg11062466 chr8:58055876 NA 0.72 8.66 0.43 2.02e-16 Developmental language disorder (linguistic errors); LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg07507251 chr3:52567010 NT5DC2 0.37 7.63 0.39 2.48e-13 Electroencephalogram traits; LUSC cis rs4363385 0.567 rs7551791 chr1:153024267 A/T cg25856811 chr1:152973957 SPRR3 -0.37 -6.06 -0.31 3.63e-9 Inflammatory skin disease; LUSC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg24250549 chr1:154909240 PMVK 0.6 9.43 0.46 7.15e-19 Prostate cancer; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg00106254 chr7:1943704 MAD1L1 -0.4 -5.81 -0.3 1.42e-8 Bipolar disorder and schizophrenia; LUSC cis rs9296092 0.538 rs9469491 chr6:33521545 A/G cg13560919 chr6:33536144 NA 0.76 14.83 0.63 1.37e-38 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs478304 0.934 rs574483 chr11:65515277 A/G cg27068330 chr11:65405492 SIPA1 0.64 9.66 0.47 1.28e-19 Acne (severe); LUSC cis rs9868809 0.505 rs9882549 chr3:48749358 C/T cg00383909 chr3:49044727 WDR6 1.14 10.61 0.5 7.19e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg26597838 chr10:835615 NA 0.98 13.46 0.59 2.73e-33 Eosinophil percentage of granulocytes; LUSC cis rs2758596 0.850 rs2241110 chr1:156172487 A/G cg24450063 chr1:156163899 SLC25A44 1.03 8.59 0.43 3.31e-16 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs5771225 0.544 rs13055135 chr22:50672479 A/G cg16473166 chr22:50639996 SELO 0.69 9.51 0.46 4e-19 Late-onset Alzheimer's disease; LUSC cis rs10740039 0.883 rs6479722 chr10:62417681 A/G cg18175470 chr10:62150864 ANK3 -0.43 -6.79 -0.35 5.23e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs77106637 0.932 rs3814730 chr11:72555553 G/A cg04827223 chr11:72435913 ARAP1 -0.67 -8.39 -0.42 1.37e-15 Type 2 diabetes; LUSC cis rs926938 0.527 rs1391484 chr1:115522366 A/G cg12756093 chr1:115239321 AMPD1 0.46 7.0 0.36 1.43e-11 Autism; LUSC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg14829155 chr15:31115871 NA -0.57 -7.96 -0.4 2.7e-14 Huntington's disease progression; LUSC cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg07061783 chr6:25882402 NA -0.37 -5.87 -0.31 1.04e-8 Blood metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14791866 chr10:82168295 C10orf58 -0.39 -5.96 -0.31 6.27e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg24549020 chr5:56110836 MAP3K1 0.49 5.71 0.3 2.48e-8 Initial pursuit acceleration; LUSC cis rs4930103 0.619 rs739905 chr11:1980360 G/C cg23202291 chr11:1979235 NA 0.49 7.81 0.39 7.62e-14 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10864318 chr6:117002220 KPNA5 0.46 6.33 0.33 8.03e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12620999 0.941 rs7593758 chr2:237980920 G/T cg23555395 chr2:238036564 NA -0.47 -8.52 -0.42 5.69e-16 Systemic lupus erythematosus; LUSC cis rs936229 0.768 rs11072509 chr15:75114374 C/G cg10253484 chr15:75165896 SCAMP2 -0.51 -6.72 -0.35 7.86e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg24675658 chr1:53192096 ZYG11B -0.61 -9.79 -0.47 4.54e-20 Monocyte count; LUSC cis rs4919687 0.550 rs7904396 chr10:104456838 C/T cg04362960 chr10:104952993 NT5C2 0.44 6.35 0.33 7.1e-10 Colorectal cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00710617 chr20:50808543 ZFP64 -0.43 -6.24 -0.32 1.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2276314 1.000 rs4799832 chr18:33559646 T/C cg19628046 chr18:33552617 C18orf21 0.51 6.11 0.32 2.76e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs8017423 0.967 rs11844225 chr14:90726676 G/A cg04374321 chr14:90722782 PSMC1 0.77 12.24 0.56 1.01e-28 Mortality in heart failure; LUSC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs34891900 0.507 rs2008085 chr22:18204316 T/G cg19898043 chr22:18121309 BCL2L13 0.38 5.85 0.3 1.19e-8 Sum neutrophil eosinophil counts; LUSC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg21132104 chr15:45694354 SPATA5L1 0.57 7.99 0.4 2.17e-14 Homoarginine levels; LUSC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg12463550 chr7:65579703 CRCP -0.55 -8.12 -0.41 9.02e-15 Aortic root size; LUSC cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.34 -5.69 -0.3 2.73e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2932538 0.961 rs12126494 chr1:113228623 G/A cg22162597 chr1:113214053 CAPZA1 0.7 9.79 0.47 4.76e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7267979 0.586 rs6050445 chr20:25195394 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.69 13.16 0.58 3.87e-32 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg04414720 chr1:150670196 GOLPH3L -0.52 -8.18 -0.41 6.03e-15 Melanoma; LUSC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg04369109 chr6:150039330 LATS1 -0.6 -8.83 -0.43 6.2e-17 Lung cancer; LUSC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs897984 0.806 rs11150600 chr16:30940331 C/T cg02466173 chr16:30829666 NA 0.55 10.96 0.51 4.25e-24 Dementia with Lewy bodies; LUSC trans rs7618501 0.602 rs2526743 chr3:50115245 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.76 -0.47 6.01e-20 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg11062466 chr8:58055876 NA 0.54 7.32 0.37 1.85e-12 Developmental language disorder (linguistic errors); LUSC cis rs7107174 0.681 rs4340079 chr11:78007920 C/T cg02023728 chr11:77925099 USP35 0.47 6.87 0.35 3.22e-11 Testicular germ cell tumor; LUSC trans rs853679 0.517 rs868987 chr6:28110148 A/G cg06606381 chr12:133084897 FBRSL1 0.45 6.23 0.32 1.4e-9 Depression; LUSC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg04267008 chr7:1944627 MAD1L1 -0.46 -6.57 -0.34 1.96e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs2354432 0.607 rs6658763 chr1:146692373 C/T cg25205988 chr1:146714368 CHD1L -0.99 -8.79 -0.43 8.13e-17 Mitochondrial DNA levels; LUSC cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.49 -0.33 3.1e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7917772 0.582 rs10786696 chr10:104378134 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4555082 0.874 rs11625098 chr14:105756891 A/G cg10792982 chr14:105748885 BRF1 0.49 8.35 0.42 1.89e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg13798912 chr7:905769 UNC84A -0.55 -5.7 -0.3 2.58e-8 Cerebrospinal P-tau181p levels; LUSC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg06112835 chr11:68658793 MRPL21 0.5 7.87 0.4 4.85e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg06112835 chr11:68658793 MRPL21 0.52 8.21 0.41 4.95e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4722404 0.800 rs10266726 chr7:3146081 C/T cg19214707 chr7:3157722 NA 0.33 5.98 0.31 5.85e-9 Atopic dermatitis; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg13685833 chr1:53393034 SCP2 0.45 6.61 0.34 1.49e-10 Monocyte count; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg10433910 chr8:145137259 GPAA1 0.5 6.12 0.32 2.61e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1358748 0.522 rs1830513 chr1:67575549 A/G cg02640540 chr1:67518911 SLC35D1 0.63 6.1 0.32 2.9e-9 Tuberculosis; LUSC cis rs7264396 0.561 rs2064725 chr20:34569142 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.76 -0.35 6.25e-11 Total cholesterol levels; LUSC cis rs11997175 0.516 rs6981283 chr8:33619363 A/G ch.8.33884649F chr8:33765107 NA 0.51 8.15 0.41 7.39e-15 Body mass index; LUSC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg27572855 chr1:25598939 RHD 0.41 7.27 0.37 2.55e-12 Erythrocyte sedimentation rate; LUSC cis rs8072100 0.811 rs9889709 chr17:45445229 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.33 -5.66 -0.3 3.21e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4845459 0.967 rs6700290 chr1:152592978 T/A cg08895932 chr1:152778580 LCE1C -0.38 -6.53 -0.34 2.46e-10 Psoriasis; LUSC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg02807482 chr3:125708958 NA -0.52 -6.49 -0.33 3.08e-10 Blood pressure (smoking interaction); LUSC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg13390004 chr1:15929781 NA 0.42 7.1 0.36 7.7e-12 Systolic blood pressure; LUSC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg03433033 chr1:76189801 ACADM 0.73 9.58 0.46 2.23e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 11.12 0.52 1.19e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -11.17 -0.52 8.06e-25 Bipolar disorder and schizophrenia; LUSC cis rs9434723 0.920 rs11801562 chr1:9293156 G/A cg04199779 chr1:9294473 H6PD 0.59 6.56 0.34 2.07e-10 Height; LUSC cis rs1670533 1.000 rs2290410 chr4:1052078 A/T cg02018176 chr4:1364513 KIAA1530 0.46 6.29 0.33 9.78e-10 Recombination rate (females); LUSC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6087990 0.899 rs1333469 chr20:31361249 C/T cg13636640 chr20:31349939 DNMT3B 1.0 22.63 0.78 2.14e-69 Ulcerative colitis; LUSC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg08213375 chr14:104286397 PPP1R13B 0.45 7.67 0.39 1.93e-13 Reticulocyte count; LUSC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.33 6.25 0.32 1.25e-9 Height;Educational attainment;Head circumference (infant); LUSC cis rs765787 0.530 rs11854689 chr15:45516052 A/G cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.44e-17 Uric acid levels; LUSC cis rs7950696 1 rs7950696 chr11:47481533 T/C cg20307385 chr11:47447363 PSMC3 0.44 6.35 0.33 7.02e-10 Platelet count; LUSC cis rs7917772 0.582 rs3936017 chr10:104354424 T/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.26e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18404041 chr3:52824283 ITIH1 -0.5 -9.49 -0.46 4.7e-19 Electroencephalogram traits; LUSC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.74 -0.39 1.21e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs2243480 0.711 rs2460426 chr7:65623129 A/G cg10756647 chr7:56101905 PSPH -0.83 -8.3 -0.41 2.64e-15 Diabetic kidney disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03309838 chr22:41215494 SLC25A17 0.44 6.99 0.36 1.47e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 8.82 0.43 6.32e-17 Menarche (age at onset); LUSC trans rs1456305 0.514 rs4571699 chr8:128099269 A/G cg22517681 chr1:24995876 SRRM1 0.65 7.39 0.37 1.21e-12 Prostate cancer; LUSC cis rs11098499 0.909 rs28714195 chr4:120316950 A/T cg09307838 chr4:120376055 NA 0.79 11.36 0.53 1.63e-25 Corneal astigmatism; LUSC cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg00509249 chr6:109615579 CCDC162 -0.34 -5.97 -0.31 5.97e-9 Reticulocyte fraction of red cells; LUSC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg08677398 chr8:58056175 NA 0.58 6.95 0.36 1.96e-11 Developmental language disorder (linguistic errors); LUSC cis rs8016982 0.674 rs2288499 chr14:81660997 C/T cg01989461 chr14:81687754 GTF2A1 0.74 13.65 0.6 5.14e-34 Schizophrenia; LUSC cis rs7011049 1.000 rs72640865 chr8:53842471 C/T cg26025543 chr8:53854495 NA 0.53 6.4 0.33 5.18e-10 Systolic blood pressure; LUSC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg06850241 chr22:41845214 NA -0.32 -6.02 -0.31 4.52e-9 Vitiligo; LUSC cis rs9814567 1.000 rs4423809 chr3:134300107 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7246967 0.673 rs4932782 chr19:22812801 A/G cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs926392 0.965 rs714108 chr20:37687838 G/A cg27552599 chr20:37590471 DHX35 0.33 5.64 0.3 3.56e-8 Dialysis-related mortality; LUSC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg03605463 chr16:89740564 NA 0.59 9.26 0.45 2.57e-18 Vitiligo; LUSC cis rs7210086 0.821 rs3935123 chr17:70641183 C/T cg04206342 chr17:70636940 NA 0.36 6.23 0.32 1.39e-9 Ulcerative colitis; LUSC cis rs3820068 0.626 rs11580170 chr1:15909744 C/T cg17385448 chr1:15911702 AGMAT 0.37 6.0 0.31 5.16e-9 Systolic blood pressure; LUSC cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.6 0.65 1.38e-41 Bladder cancer; LUSC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg14440974 chr22:39074834 NA -0.35 -5.84 -0.3 1.26e-8 Menopause (age at onset); LUSC cis rs1572072 0.762 rs9510775 chr13:24129102 C/G cg24350296 chr13:24144486 TNFRSF19 -0.3 -5.76 -0.3 1.93e-8 Nasopharyngeal carcinoma; LUSC cis rs2625529 0.652 rs8023788 chr15:72459847 A/G cg16672083 chr15:72433130 SENP8 0.48 7.92 0.4 3.5e-14 Red blood cell count; LUSC cis rs2290159 0.706 rs6442319 chr3:12647029 G/A cg23032965 chr3:12705835 RAF1 0.74 8.96 0.44 2.42e-17 Cholesterol, total; LUSC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg14262678 chr6:151773367 RMND1;C6orf211 0.5 7.99 0.4 2.2e-14 Menarche (age at onset); LUSC trans rs12188164 0.686 rs72711365 chr5:416672 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.42 6.55 0.34 2.21e-10 Cystic fibrosis severity; LUSC trans rs208515 0.525 rs10944868 chr6:66687508 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.02 13.99 0.61 2.52e-35 Exhaled nitric oxide levels; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg01577475 chr2:114033581 PAX8;LOC440839 0.3 7.53 0.38 4.93e-13 Lymphocyte counts; LUSC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg16447950 chr5:562315 NA -0.57 -6.94 -0.36 2.02e-11 Obesity-related traits; LUSC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg23172400 chr8:95962367 TP53INP1 -0.39 -7.88 -0.4 4.63e-14 Type 2 diabetes; LUSC cis rs72781680 0.898 rs72788212 chr2:24087385 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.8 0.3 1.56e-8 Lymphocyte counts; LUSC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg08470875 chr2:26401718 FAM59B -0.69 -9.19 -0.45 4.4e-18 Gut microbiome composition (summer); LUSC cis rs6906287 0.631 rs2798321 chr6:118991602 G/T cg21191810 chr6:118973309 C6orf204 0.33 6.05 0.31 3.95e-9 Electrocardiographic conduction measures; LUSC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg18876405 chr7:65276391 NA -0.54 -8.5 -0.42 6.26e-16 Aortic root size; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg05702448 chr1:167905194 DCAF6;BRP44 0.34 6.16 0.32 2.03e-9 Metabolite levels (Pyroglutamine); LUSC cis rs12545109 0.879 rs2670015 chr8:57376607 T/A cg09654669 chr8:57350985 NA -0.57 -7.46 -0.38 7.7e-13 Obesity-related traits; LUSC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg10523679 chr1:76189770 ACADM 0.89 15.49 0.65 3.73e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2295359 0.892 rs4655686 chr1:67638004 T/A cg03340356 chr1:67600835 NA 0.43 6.71 0.34 8.16e-11 Psoriasis; LUSC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg04450456 chr4:17643702 FAM184B 0.38 6.55 0.34 2.17e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2230307 0.536 rs700533 chr1:100483822 A/G cg24955406 chr1:100503596 HIAT1 0.57 6.14 0.32 2.35e-9 Carotid intima media thickness; LUSC cis rs1801251 1.000 rs6761324 chr2:233582793 T/G cg08000102 chr2:233561755 GIGYF2 0.68 11.43 0.53 9.24e-26 Coronary artery disease; LUSC cis rs12682352 0.535 rs12677550 chr8:8644322 A/G cg18904891 chr8:8559673 CLDN23 -0.4 -5.97 -0.31 6.22e-9 Neuroticism; LUSC cis rs11608355 0.545 rs4766475 chr12:109908373 G/A cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg08132940 chr7:1081526 C7orf50 -0.46 -5.7 -0.3 2.59e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg15839431 chr19:19639596 YJEFN3 -0.41 -5.81 -0.3 1.47e-8 Tonsillectomy; LUSC trans rs11039798 0.588 rs7108164 chr11:48626363 A/C cg15704280 chr7:45808275 SEPT13 0.65 7.19 0.37 4.24e-12 Axial length; LUSC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg06221963 chr1:154839813 KCNN3 -0.62 -13.89 -0.61 6.01e-35 Prostate cancer; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg09412528 chr12:98987242 SLC25A3 0.49 5.94 0.31 7.06e-9 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg23505145 chr19:12996616 KLF1 0.65 10.98 0.51 3.66e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg16325326 chr1:53192061 ZYG11B -0.71 -11.05 -0.52 2.05e-24 Monocyte count; LUSC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.33 0.59 8.66e-33 Monocyte percentage of white cells; LUSC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg07936489 chr17:37558343 FBXL20 0.71 10.04 0.48 6.73e-21 Glomerular filtration rate (creatinine); LUSC trans rs2048656 0.605 rs7837008 chr8:9646506 T/C cg06636001 chr8:8085503 FLJ10661 0.45 6.3 0.33 9.56e-10 Schizophrenia; LUSC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg14552801 chr7:65878734 NA 0.38 5.91 0.31 8.29e-9 Aortic root size; LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.59 -0.46 2.15e-19 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs757110 0.745 rs2074311 chr11:17421860 A/G cg15432903 chr11:17409602 KCNJ11 0.46 7.83 0.39 6.69e-14 Type 2 diabetes; LUSC cis rs3126085 0.935 rs11204939 chr1:152200942 G/C cg03465714 chr1:152285911 FLG -0.41 -5.86 -0.31 1.09e-8 Atopic dermatitis; LUSC cis rs79349575 0.783 rs62078370 chr17:47026836 G/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs4474465 0.850 rs4482052 chr11:78263331 A/G cg27205649 chr11:78285834 NARS2 0.52 6.13 0.32 2.45e-9 Alzheimer's disease (survival time); LUSC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg22903471 chr2:27725779 GCKR -0.41 -6.86 -0.35 3.28e-11 Total body bone mineral density; LUSC trans rs11098499 0.738 rs10026493 chr4:120384194 C/G cg25214090 chr10:38739885 LOC399744 0.57 8.42 0.42 1.14e-15 Corneal astigmatism; LUSC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg09021430 chr5:549028 NA -0.54 -8.54 -0.42 4.75e-16 Obesity-related traits; LUSC cis rs7759001 0.857 rs9468115 chr6:27363587 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.66 0.3 3.26e-8 Glomerular filtration rate (creatinine); LUSC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.89e-12 Blood metabolite levels; LUSC cis rs225245 0.755 rs6505491 chr17:34026335 A/G cg05299278 chr17:33885742 SLFN14 0.29 6.44 0.33 4.11e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg02117656 chr17:79614917 TSPAN10 0.32 5.81 0.3 1.46e-8 Eye color traits; LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg14159672 chr1:205819179 PM20D1 0.47 6.75 0.35 6.45e-11 Prostate-specific antigen levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18895155 chr7:99214691 ZNF498 0.39 5.98 0.31 5.81e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12493885 0.872 rs9840371 chr3:153796829 C/T cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg10811474 chr19:8428787 ANGPTL4 -0.39 -5.97 -0.31 6.16e-9 HDL cholesterol; LUSC cis rs9303401 0.703 rs8077052 chr17:57208921 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.55 8.23 0.41 4.13e-15 Cognitive test performance; LUSC cis rs4073582 0.595 rs1151540 chr11:66041807 A/C cg16950941 chr11:66035639 RAB1B 0.53 7.8 0.39 7.82e-14 Gout; LUSC cis rs55665837 1.000 rs10047429 chr11:14439032 C/T cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg21300267 chr1:26547059 NA -0.24 -5.66 -0.3 3.3e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg27398817 chr8:82754497 SNX16 -0.54 -7.65 -0.39 2.13e-13 Diastolic blood pressure; LUSC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg13685833 chr1:53393034 SCP2 0.4 6.0 0.31 5.27e-9 Monocyte count; LUSC cis rs6681460 1.000 rs6588207 chr1:67066555 A/G cg02459107 chr1:67143332 SGIP1 0.48 8.93 0.44 2.91e-17 Presence of antiphospholipid antibodies; LUSC cis rs73206853 0.640 rs871921 chr12:111115113 G/C cg12870014 chr12:110450643 ANKRD13A 0.75 9.66 0.47 1.3e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7959663 1 rs7959663 chr12:109884367 G/C cg05360138 chr12:110035743 NA 0.67 9.11 0.45 7.65e-18 Bipolar disorder lithium response (categorical) or schizophrenia; LUSC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg01579765 chr21:45077557 HSF2BP 0.55 11.3 0.53 2.72e-25 Mean corpuscular volume; LUSC cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.05 0.44 1.25e-17 Total body bone mineral density; LUSC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg07157834 chr1:205819609 PM20D1 -0.42 -5.69 -0.3 2.85e-8 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg20243544 chr17:37824526 PNMT 0.51 7.24 0.37 3.05e-12 Asthma; LUSC trans rs7493 1.000 rs7493 chr7:95034775 C/G cg23291145 chr4:41648620 LIMCH1 0.38 5.96 0.31 6.52e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg11645453 chr3:52864694 ITIH4 -0.42 -10.35 -0.49 5.63e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9463078 0.764 rs9357464 chr6:44952441 T/C cg25276700 chr6:44698697 NA -0.28 -5.85 -0.3 1.16e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg27432699 chr2:27873401 GPN1 0.57 8.67 0.43 1.92e-16 Total body bone mineral density; LUSC cis rs11112613 0.713 rs11112590 chr12:105951376 C/G cg03607813 chr12:105948248 NA -0.79 -11.77 -0.54 5.53e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs6964587 0.900 rs6972027 chr7:91781380 T/C cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.57e-8 Breast cancer; LUSC cis rs2688608 0.620 rs7080350 chr10:75577843 A/G cg17411546 chr10:75410026 SYNPO2L 0.53 8.05 0.4 1.43e-14 Inflammatory bowel disease; LUSC cis rs477692 0.647 rs524804 chr10:131430686 G/A cg05714579 chr10:131428358 MGMT -0.66 -10.46 -0.5 2.39e-22 Response to temozolomide; LUSC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg12292205 chr6:26970375 C6orf41 -0.58 -7.35 -0.37 1.49e-12 Intelligence (multi-trait analysis); LUSC cis rs7793919 0.726 rs4720401 chr7:4780943 G/A cg00064840 chr7:4784485 FOXK1 0.31 5.88 0.31 9.82e-9 Mosquito bite size; LUSC cis rs17270561 0.666 rs9356988 chr6:25777481 G/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.24 0.37 3.02e-12 Iron status biomarkers; LUSC trans rs4689388 0.853 rs4293850 chr4:6292020 A/C cg17567195 chr5:167378696 ODZ2 -0.37 -5.97 -0.31 5.97e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs12692738 0.526 rs355873 chr2:165632464 T/C cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7107174 0.681 rs10899499 chr11:78124797 A/G cg02023728 chr11:77925099 USP35 -0.45 -6.78 -0.35 5.42e-11 Testicular germ cell tumor; LUSC trans rs2229238 0.911 rs11490956 chr1:154487258 G/T cg25273160 chr11:56955011 LRRC55 0.32 6.23 0.32 1.44e-9 Coronary heart disease; LUSC cis rs9304742 0.573 rs10415950 chr19:53465100 C/T cg09915433 chr19:53449742 NA -0.43 -6.9 -0.35 2.64e-11 Psoriasis; LUSC cis rs17001868 0.568 rs10854729 chr22:40750612 T/C cg07138101 chr22:40742427 ADSL 0.52 6.36 0.33 6.53e-10 Mammographic density (dense area); LUSC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.36 0.56 3.74e-29 Cognitive test performance; LUSC cis rs17270561 0.609 rs9393655 chr6:25711338 A/G cg17691542 chr6:26056736 HIST1H1C 0.57 7.92 0.4 3.62e-14 Iron status biomarkers; LUSC cis rs12618769 0.597 rs4851142 chr2:99133611 A/C cg10123293 chr2:99228465 UNC50 0.44 7.33 0.37 1.77e-12 Bipolar disorder; LUSC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg00383909 chr3:49044727 WDR6 0.42 5.71 0.3 2.51e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.87 0.35 3.08e-11 Multiple sclerosis; LUSC cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg00071950 chr4:10020882 SLC2A9 -0.57 -9.22 -0.45 3.33e-18 Bone mineral density; LUSC cis rs2219968 1.000 rs6473084 chr8:78972524 T/C cg00738934 chr8:78996279 NA 0.35 6.23 0.32 1.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7903847 0.642 rs7092499 chr10:99140313 A/G cg08345082 chr10:99160200 RRP12 -0.34 -7.0 -0.36 1.37e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs7100689 0.784 rs1972370 chr10:82127180 A/G cg00277334 chr10:82204260 NA -0.49 -6.77 -0.35 5.89e-11 Post bronchodilator FEV1; LUSC trans rs10221833 1.000 rs441414 chr2:165675693 A/G cg04527071 chr11:1473128 BRSK2 -0.52 -6.16 -0.32 2.14e-9 Response to statin therapy; LUSC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.12e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.08 -0.36 8.35e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg09184832 chr6:79620586 NA -0.45 -7.29 -0.37 2.24e-12 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.875 rs1962901 chr8:101326428 A/G cg06636551 chr8:101224915 SPAG1 -0.39 -7.27 -0.37 2.64e-12 Atrioventricular conduction; LUSC cis rs9652601 0.959 rs9746695 chr16:11207894 C/T cg04616529 chr16:11181986 CLEC16A -0.33 -5.68 -0.3 2.94e-8 Systemic lupus erythematosus; LUSC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg12463550 chr7:65579703 CRCP -0.55 -8.19 -0.41 5.55e-15 Aortic root size; LUSC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg07414643 chr4:187882934 NA -0.54 -10.28 -0.49 1.05e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs765787 0.505 rs11630884 chr15:45532246 C/T cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.32e-11 Uric acid levels; LUSC cis rs977987 0.736 rs11865296 chr16:75473693 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.23 -0.37 3.35e-12 Dupuytren's disease; LUSC cis rs231513 0.954 rs231524 chr17:41953212 G/A cg26893861 chr17:41843967 DUSP3 -0.51 -5.96 -0.31 6.5e-9 Cognitive function; LUSC cis rs1160297 0.575 rs10865272 chr2:53093447 C/T cg07782112 chr2:53107842 NA 0.37 6.23 0.32 1.38e-9 Hemostatic factors and hematological phenotypes; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg24702147 chr12:7071814 MIR141;MIR200C -0.24 -6.17 -0.32 1.95e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg17366294 chr4:99064904 C4orf37 0.54 9.54 0.46 3.1400000000000002e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs243505 0.668 rs2072406 chr7:148483760 G/A cg09806900 chr7:148480153 CUL1 0.59 8.68 0.43 1.72e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1577917 0.740 rs7775864 chr6:86247759 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 9.09 0.45 8.72e-18 Response to antipsychotic treatment; LUSC cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg06784218 chr1:46089804 CCDC17 0.48 9.49 0.46 4.5e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4595586 0.545 rs969468 chr12:39367278 A/C cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs4266144 0.592 rs1545854 chr3:156840138 A/G cg14969094 chr3:156848003 NA 0.35 5.72 0.3 2.38e-8 Coronary artery disease; LUSC cis rs7202877 0.706 rs8055609 chr16:75402088 C/T cg03315344 chr16:75512273 CHST6 0.42 6.24 0.32 1.32e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.9 0.48 2e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2898290 0.540 rs12677146 chr8:11450737 C/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.85 -0.3 1.16e-8 Systolic blood pressure; LUSC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08945467 chr1:58522070 DAB1 0.48 6.06 0.31 3.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg19046167 chr17:80928561 B3GNTL1 -0.46 -6.68 -0.34 1.02e-10 Breast cancer; LUSC cis rs3820068 0.608 rs12091644 chr1:16044945 G/A cg13390004 chr1:15929781 NA 0.42 6.64 0.34 1.3100000000000001e-10 Systolic blood pressure; LUSC trans rs156356 0.811 rs552067 chr20:1823326 C/G cg04365817 chr1:101491640 DPH5 0.43 6.15 0.32 2.16e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.41e-9 Crohn's disease; LUSC cis rs9653442 0.545 rs11123813 chr2:100765692 C/T cg22139774 chr2:100720529 AFF3 -0.42 -7.32 -0.37 1.81e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs8141797 0.901 rs176157 chr22:24503987 C/T cg00411358 chr22:24577142 SUSD2 -0.61 -6.3 -0.33 9.43e-10 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs75804782 0.641 rs1030786 chr2:239361150 A/G cg18131467 chr2:239335373 ASB1 -0.72 -6.6 -0.34 1.64e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.17 -0.37 4.88e-12 Intelligence (multi-trait analysis); LUSC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.4 0.46 9.01e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1018697 0.518 rs2250301 chr10:104548393 G/A cg04362960 chr10:104952993 NT5C2 -0.65 -7.65 -0.39 2.18e-13 Colorectal adenoma (advanced); LUSC cis rs1797081 1.000 rs780634 chr10:16864327 T/G cg23933602 chr10:16859644 RSU1 1.01 21.83 0.77 2.97e-66 Platelet distribution width; LUSC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg26769984 chr7:1090371 C7orf50 0.69 9.72 0.47 7.73e-20 Bronchopulmonary dysplasia; LUSC cis rs7592578 0.882 rs61117285 chr2:191468986 G/C cg10560079 chr2:191398806 TMEM194B -0.68 -8.64 -0.43 2.45e-16 Diastolic blood pressure; LUSC cis rs7572644 0.640 rs4555299 chr2:28071190 A/G cg27432699 chr2:27873401 GPN1 0.51 6.89 0.35 2.76e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs12579753 1.000 rs11519754 chr12:82209181 A/T cg07988820 chr12:82153109 PPFIA2 -0.44 -6.13 -0.32 2.51e-9 Resting heart rate; LUSC trans rs61931739 0.857 rs1828514 chr12:34139600 A/G cg26384229 chr12:38710491 ALG10B 0.57 9.05 0.44 1.24e-17 Morning vs. evening chronotype; LUSC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg23630131 chr7:65973040 NA -0.2 -5.73 -0.3 2.2e-8 Aortic root size; LUSC cis rs6723226 0.721 rs3769600 chr2:32616879 G/A cg02381751 chr2:32503542 YIPF4 -0.56 -8.68 -0.43 1.82e-16 Intelligence (multi-trait analysis); LUSC cis rs425277 1.000 rs1401138 chr1:2063149 C/T cg03732007 chr1:2071316 PRKCZ 0.48 7.76 0.39 1.05e-13 Height; LUSC cis rs76878669 0.561 rs10750784 chr11:66110666 A/G cg18002602 chr11:66138449 SLC29A2 -0.49 -8.75 -0.43 1.09e-16 Educational attainment (years of education); LUSC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.49 0.38 6.36e-13 Bipolar disorder; LUSC cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg04756594 chr16:24857601 SLC5A11 0.34 5.66 0.3 3.25e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.8 0.39 8.05e-14 Gut microbiome composition (summer); LUSC cis rs9473147 0.516 rs7749271 chr6:47485002 T/C cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18099408 chr3:52552593 STAB1 0.42 7.73 0.39 1.27e-13 Electroencephalogram traits; LUSC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg09655341 chr17:79618100 PDE6G 0.3 7.0 0.36 1.45e-11 Eye color traits; LUSC trans rs72834455 0.925 rs72834464 chr2:119517615 G/T cg02397686 chr17:73851076 WBP2 -0.65 -6.09 -0.32 3.19e-9 Tonsillectomy; LUSC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -8.12 -0.41 9.14e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg04455712 chr21:45112962 RRP1B 0.51 9.75 0.47 6.24e-20 Mean corpuscular volume; LUSC cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs7954584 0.531 rs6486781 chr12:122318985 A/C cg21171335 chr12:122356390 WDR66 0.57 8.22 0.41 4.56e-15 Mean corpuscular volume; LUSC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg09455208 chr3:40491958 NA 0.51 8.87 0.44 4.38e-17 Renal cell carcinoma; LUSC cis rs7927592 0.913 rs4316515 chr11:68308840 A/T cg20283391 chr11:68216788 NA 0.61 8.47 0.42 7.8e-16 Total body bone mineral density; LUSC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs763121 0.853 rs2179142 chr22:39037954 G/A cg06544989 chr22:39130855 UNC84B 0.33 5.71 0.3 2.49e-8 Menopause (age at onset); LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg20887711 chr4:1340912 KIAA1530 0.46 7.04 0.36 1.07e-11 Obesity-related traits; LUSC cis rs7296418 0.599 rs2277343 chr12:123794450 A/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.63 -0.34 1.3100000000000001e-10 Platelet count; LUSC cis rs3741151 0.686 rs17132115 chr11:73264656 C/T cg17517138 chr11:73019481 ARHGEF17 0.82 7.65 0.39 2.15e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg04944784 chr2:26401820 FAM59B 0.77 11.17 0.52 7.68e-25 Gut microbiome composition (summer); LUSC cis rs367615 0.552 rs10042721 chr5:108713970 C/T cg17395555 chr5:108820864 NA -0.47 -8.2 -0.41 5.06e-15 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg04369109 chr6:150039330 LATS1 -0.6 -8.74 -0.43 1.16e-16 Lung cancer; LUSC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg21361702 chr7:150065534 REPIN1 0.48 6.44 0.33 4.16e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7119 0.651 rs17394732 chr15:77835657 A/G cg27398640 chr15:77910606 LINGO1 0.31 6.5 0.34 2.93e-10 Type 2 diabetes; LUSC cis rs593982 0.843 rs680948 chr11:65472394 C/G cg08755490 chr11:65554678 OVOL1 1.52 13.05 0.58 9.92e-32 Atopic dermatitis; LUSC trans rs225245 0.817 rs225284 chr17:33933006 A/C cg19694781 chr19:47549865 TMEM160 -0.44 -7.01 -0.36 1.29e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg18904891 chr8:8559673 CLDN23 0.6 8.23 0.41 4.27e-15 Obesity-related traits; LUSC cis rs6840360 0.550 rs12651635 chr4:152557786 C/T cg22705602 chr4:152727874 NA -0.3 -5.95 -0.31 6.96e-9 Intelligence (multi-trait analysis); LUSC cis rs7131987 0.650 rs16934135 chr12:29483963 T/G cg09582351 chr12:29534625 ERGIC2 -0.33 -6.68 -0.34 9.9e-11 QT interval; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg05313129 chr8:58192883 C8orf71 -0.51 -5.79 -0.3 1.62e-8 Developmental language disorder (linguistic errors); LUSC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg08704250 chr15:31115839 NA -0.59 -9.24 -0.45 2.97e-18 Huntington's disease progression; LUSC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg26441486 chr22:50317300 CRELD2 0.48 7.21 0.37 3.88e-12 Schizophrenia; LUSC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg07092213 chr7:1199455 ZFAND2A 0.43 6.66 0.34 1.14e-10 Longevity;Endometriosis; LUSC trans rs12458462 0.787 rs56006341 chr18:77439844 G/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.8 -0.35 4.8e-11 Monocyte count; LUSC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg13010199 chr12:38710504 ALG10B 0.67 9.99 0.48 9.58e-21 Bladder cancer; LUSC cis rs2279817 0.913 rs11203436 chr1:18019016 T/C cg21791023 chr1:18019539 ARHGEF10L 0.54 6.96 0.36 1.85e-11 Neuroticism; LUSC cis rs72781680 0.784 rs12616678 chr2:24181159 G/T cg08917208 chr2:24149416 ATAD2B 0.6 6.94 0.35 2.07e-11 Lymphocyte counts; LUSC cis rs7954584 0.551 rs1169072 chr12:122401501 C/T cg21016266 chr12:122356598 WDR66 -0.5 -7.33 -0.37 1.77e-12 Mean corpuscular volume; LUSC cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.51 -6.83 -0.35 4.14e-11 Tonsillectomy; LUSC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg06112835 chr11:68658793 MRPL21 0.49 7.59 0.38 3.21e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg06784218 chr1:46089804 CCDC17 0.52 10.14 0.49 2.96e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9462027 0.628 rs7769961 chr6:34760162 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC cis rs11864453 0.713 rs6680 chr16:72146570 T/C cg16558253 chr16:72132732 DHX38 -0.37 -5.79 -0.3 1.58e-8 Fibrinogen levels; LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg00431813 chr7:1051703 C7orf50 -0.45 -7.86 -0.39 5.5e-14 Longevity;Endometriosis; LUSC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg20283391 chr11:68216788 NA 0.54 8.21 0.41 4.74e-15 Total body bone mineral density; LUSC cis rs7177699 0.557 rs11072807 chr15:79111517 A/G cg00540400 chr15:79124168 NA 0.48 8.41 0.42 1.25e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1577917 1.000 rs34281561 chr6:86701872 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.89 -0.35 2.72e-11 Response to antipsychotic treatment; LUSC cis rs7592578 0.603 rs12476782 chr2:191472880 G/A cg10560079 chr2:191398806 TMEM194B -0.52 -6.5 -0.33 2.98e-10 Diastolic blood pressure; LUSC cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Drug-induced liver injury (flucloxacillin); LUSC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg03929089 chr4:120376271 NA -0.79 -12.8 -0.57 8.41e-31 Height; LUSC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg02034447 chr16:89574710 SPG7 0.42 6.25 0.32 1.24e-9 Multiple myeloma (IgH translocation); LUSC cis rs5769707 0.521 rs5770633 chr22:50062427 G/A cg05373962 chr22:49881684 NA -0.39 -8.25 -0.41 3.62e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1018836 0.923 rs2157607 chr8:91600268 A/G cg16814680 chr8:91681699 NA -0.77 -12.79 -0.57 9.61e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.56 -0.34 2.11e-10 Monocyte percentage of white cells; LUSC cis rs61931739 0.534 rs10506120 chr12:34235603 G/A cg06521331 chr12:34319734 NA -0.47 -7.76 -0.39 1.06e-13 Morning vs. evening chronotype; LUSC cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg07606381 chr6:8435919 SLC35B3 0.73 12.18 0.55 1.79e-28 Motion sickness; LUSC cis rs7727544 0.582 rs4361509 chr5:131536753 A/G cg14196790 chr5:131705035 SLC22A5 -0.45 -7.51 -0.38 5.43e-13 Blood metabolite levels; LUSC trans rs9467711 0.559 rs13208916 chr6:26601940 G/A cg06606381 chr12:133084897 FBRSL1 -0.69 -6.84 -0.35 3.74e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs77106637 0.858 rs117819392 chr11:72514503 C/T cg03713592 chr11:72463424 ARAP1 0.83 9.68 0.47 1.1e-19 Type 2 diabetes; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg21782813 chr7:2030301 MAD1L1 0.36 5.84 0.3 1.27e-8 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg12463550 chr7:65579703 CRCP -0.52 -7.45 -0.38 8.2e-13 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23223044 chr19:49990882 RPL13AP5;RPL13A 0.43 6.29 0.33 1.02e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs782590 0.774 rs782637 chr2:55894247 T/C cg18811423 chr2:55921094 PNPT1 0.89 15.63 0.65 1.03e-41 Metabolic syndrome; LUSC cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg16230307 chr14:35515116 FAM177A1 0.78 10.15 0.49 2.9e-21 Psoriasis; LUSC cis rs7824557 0.650 rs2572406 chr8:11092252 C/G cg21775007 chr8:11205619 TDH 0.45 6.83 0.35 4.13e-11 Retinal vascular caliber; LUSC cis rs2742417 1.000 rs1877933 chr3:45753487 C/T cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg14668632 chr7:2872130 GNA12 -0.44 -6.44 -0.33 4.16e-10 Height; LUSC cis rs72781680 0.799 rs17508218 chr2:23976536 C/T cg20701182 chr2:24300061 SF3B14 0.57 6.02 0.31 4.55e-9 Lymphocyte counts; LUSC cis rs60154123 0.730 rs4844989 chr1:210460086 C/T cg22029157 chr1:209979665 IRF6 0.52 5.81 0.3 1.46e-8 Coronary artery disease; LUSC cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.78 7.71 0.39 1.47e-13 Initial pursuit acceleration; LUSC cis rs2486288 0.587 rs12899942 chr15:45547280 T/C cg09092052 chr15:45571596 NA 0.46 6.41 0.33 5.09e-10 Glomerular filtration rate; LUSC cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg08999081 chr20:33150536 PIGU -0.4 -7.35 -0.37 1.56e-12 Glomerular filtration rate (creatinine); LUSC cis rs778371 0.676 rs4973563 chr2:233716421 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -12.26 -0.56 8.95e-29 Schizophrenia; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg00409905 chr10:38381863 ZNF37A -0.36 -6.17 -0.32 1.98e-9 Extrinsic epigenetic age acceleration; LUSC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg24531977 chr5:56204891 C5orf35 -1.05 -15.38 -0.64 9.96e-41 Initial pursuit acceleration; LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs748404 0.697 rs501884 chr15:43553982 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.35 0.42 1.82e-15 Lung cancer; LUSC trans rs7939886 0.920 rs17149859 chr11:55795356 G/A cg03929089 chr4:120376271 NA 0.74 6.25 0.32 1.29e-9 Myopia (pathological); LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg13047869 chr3:10149882 C3orf24 0.62 8.71 0.43 1.39e-16 Alzheimer's disease; LUSC cis rs72634258 0.786 rs4268374 chr1:8174083 G/T cg00042356 chr1:8021962 PARK7 -0.54 -6.6 -0.34 1.65e-10 Inflammatory bowel disease; LUSC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg12927641 chr6:109611667 NA -0.43 -7.62 -0.38 2.71e-13 Reticulocyte fraction of red cells; LUSC cis rs2425143 1.000 rs17093027 chr20:34319118 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.27 -0.32 1.14e-9 Blood protein levels; LUSC cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.13 -0.36 6.32e-12 Menopause (age at onset); LUSC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.54 -0.34 2.36e-10 Endometrial cancer; LUSC cis rs8072100 0.967 rs4239162 chr17:45755810 G/A cg08085267 chr17:45401833 C17orf57 -0.56 -9.09 -0.45 9.09e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs877282 0.898 rs12359731 chr10:759497 A/G cg22713356 chr15:30763199 NA 0.95 13.94 0.61 3.88e-35 Uric acid levels; LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg17219203 chr10:38645113 HSD17B7P2 -0.52 -7.59 -0.38 3.13e-13 Breast cancer; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg01516881 chr6:292596 DUSP22 -0.7 -11.12 -0.52 1.2e-24 Menopause (age at onset); LUSC cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg14829155 chr15:31115871 NA -0.54 -7.12 -0.36 6.62e-12 Huntington's disease progression; LUSC cis rs652260 0.663 rs580984 chr19:7881030 C/T cg26014689 chr19:7917955 EVI5L -0.39 -6.1 -0.32 2.94e-9 Menarche (age at onset); LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg10802521 chr3:52805072 NEK4 -0.55 -8.72 -0.43 1.32e-16 Bipolar disorder; LUSC cis rs4356932 1.000 rs7688306 chr4:76982046 A/G cg00809888 chr4:76862425 NAAA 0.35 5.76 0.3 1.93e-8 Blood protein levels; LUSC cis rs7726839 0.540 rs72703079 chr5:595173 T/C cg16447950 chr5:562315 NA -0.58 -7.3 -0.37 2.1e-12 Obesity-related traits; LUSC cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg04511125 chr2:88470314 THNSL2 0.97 9.55 0.46 2.87e-19 Plasma clusterin levels; LUSC cis rs2219968 1.000 rs7818353 chr8:78972826 C/A cg00738934 chr8:78996279 NA 0.35 6.23 0.32 1.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg22857025 chr5:266934 NA -1.13 -15.1 -0.64 1.19e-39 Breast cancer; LUSC cis rs2075165 0.901 rs2274226 chr1:156314627 C/T cg20302342 chr1:156215951 PAQR6 -0.32 -6.32 -0.33 8.34e-10 Tonsillectomy; LUSC cis rs394563 0.601 rs391875 chr6:149795136 G/A cg07828024 chr6:149772892 ZC3H12D -0.38 -7.93 -0.4 3.37e-14 Dupuytren's disease; LUSC cis rs2996428 0.667 rs17412654 chr1:3758493 T/C cg13057898 chr1:3703894 LRRC47 0.52 8.86 0.44 4.96e-17 Red cell distribution width; LUSC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg03433033 chr1:76189801 ACADM 0.84 15.31 0.64 1.93e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9653442 0.675 rs1115910 chr2:100647872 A/G cg07810366 chr2:100720526 AFF3 -0.41 -6.79 -0.35 5.24e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7712401 0.562 rs383638 chr5:122324678 A/C cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs9807989 0.839 rs7603730 chr2:102974371 A/C cg09003973 chr2:102972529 NA 0.43 5.88 0.31 9.84e-9 Asthma; LUSC cis rs34421088 0.532 rs2736388 chr8:11159588 T/C cg27411982 chr8:10470053 RP1L1 0.37 5.64 0.3 3.57e-8 Neuroticism; LUSC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg11301795 chr4:187892539 NA -0.72 -12.16 -0.55 2e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs28735056 0.509 rs4799094 chr18:77621727 T/C cg17174613 chr18:77631625 KCNG2 0.31 6.5 0.34 2.94e-10 Schizophrenia; LUSC trans rs9929218 0.551 rs3785133 chr16:68728611 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 22.76 0.78 6.44e-70 Colorectal cancer; LUSC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg27432699 chr2:27873401 GPN1 -0.51 -7.42 -0.38 9.52e-13 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.2 16.31 0.67 2.22e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg07636037 chr3:49044803 WDR6 0.57 6.07 0.32 3.39e-9 Menarche (age at onset); LUSC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC trans rs853679 0.546 rs200954 chr6:27838764 C/G cg06606381 chr12:133084897 FBRSL1 -0.8 -7.62 -0.38 2.63e-13 Depression; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08172935 chr17:66244127 AMZ2 -0.43 -6.56 -0.34 2.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs68170813 0.617 rs10464499 chr7:107137571 C/T cg24556660 chr7:106842632 COG5;HBP1 -0.46 -5.7 -0.3 2.7e-8 Coronary artery disease; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg20821713 chr7:1055600 C7orf50 -0.38 -5.92 -0.31 7.85e-9 Longevity;Endometriosis; LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9389248 0.690 rs2072826 chr6:135253558 G/C cg24558204 chr6:135376177 HBS1L -0.59 -8.67 -0.43 1.9e-16 High light scatter reticulocyte percentage of red cells; LUSC trans rs877282 0.945 rs12767287 chr10:787310 A/G cg13042288 chr15:90349979 ANPEP -0.46 -6.6 -0.34 1.63e-10 Uric acid levels; LUSC cis rs12760731 0.565 rs12027396 chr1:178149200 T/C cg00404053 chr1:178313656 RASAL2 0.66 6.8 0.35 4.85e-11 Obesity-related traits; LUSC cis rs2979489 0.740 rs17554408 chr8:30427531 A/G cg26383811 chr8:30366931 RBPMS 0.43 6.59 0.34 1.69e-10 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs4380275 1.000 rs4268954 chr2:772834 A/G cg21665850 chr2:731073 NA 0.41 6.7 0.34 8.85e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs9660992 0.710 rs55671824 chr1:205249814 G/A cg21545522 chr1:205238299 TMCC2 0.5 9.3 0.45 1.9e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs17685 0.753 rs10262501 chr7:75668172 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.5 7.73 0.39 1.3e-13 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs11165623 0.765 rs11807955 chr1:96891623 C/T cg10631902 chr5:14652156 NA -0.56 -9.06 -0.44 1.11e-17 Hip circumference;Waist circumference; LUSC trans rs11098499 0.954 rs13151285 chr4:120314741 C/A cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg06634786 chr22:41940651 POLR3H 0.49 5.72 0.3 2.38e-8 Vitiligo; LUSC cis rs17253792 0.822 rs10148983 chr14:56051879 A/G cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs11105298 0.891 rs11105310 chr12:89918677 C/A cg00757033 chr12:89920650 WDR51B 0.59 10.22 0.49 1.69e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.52e-9 Menopause (age at onset); LUSC trans rs9329221 0.657 rs17694485 chr8:10114458 A/T cg06636001 chr8:8085503 FLJ10661 0.48 6.57 0.34 1.96e-10 Neuroticism; LUSC cis rs12579753 1.000 rs11115030 chr12:82203021 A/T cg21231944 chr12:82153410 PPFIA2 -0.38 -5.85 -0.3 1.15e-8 Resting heart rate; LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.85 12.59 0.57 5.35e-30 Cognitive ability; LUSC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg11645453 chr3:52864694 ITIH4 -0.38 -8.84 -0.44 5.69e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg21704491 chr20:388519 RBCK1 0.37 6.09 0.32 3.04e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs2404602 0.692 rs12910734 chr15:77149931 A/G cg23625390 chr15:77176239 SCAPER 0.48 7.28 0.37 2.37e-12 Blood metabolite levels; LUSC cis rs9916302 0.706 rs9891892 chr17:37479856 A/C cg07936489 chr17:37558343 FBXL20 0.81 9.98 0.48 1.09e-20 Glomerular filtration rate (creatinine); LUSC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg06008330 chr7:65541103 ASL -0.4 -6.31 -0.33 8.86e-10 Aortic root size; LUSC cis rs8177253 0.632 rs6782523 chr3:133438917 C/T cg08048268 chr3:133502702 NA -0.37 -6.46 -0.33 3.74e-10 Iron status biomarkers; LUSC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg03188948 chr7:1209495 NA 0.45 6.03 0.31 4.28e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.590 rs2066322 chr10:104909339 T/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.45 -0.33 3.93e-10 Arsenic metabolism; LUSC cis rs4700695 0.719 rs27087 chr5:65453050 G/A cg21114390 chr5:65439923 SFRS12 -0.63 -8.98 -0.44 2.07e-17 Facial morphology (factor 19); LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs35123781 1.000 rs601336 chr5:139057167 T/C cg10513866 chr5:139070639 NA 0.46 8.9 0.44 3.62e-17 Schizophrenia; LUSC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg11764359 chr7:65958608 NA -0.8 -13.13 -0.58 4.83e-32 Aortic root size; LUSC cis rs1994135 0.715 rs10844624 chr12:33691010 A/G cg06521331 chr12:34319734 NA -0.38 -5.69 -0.3 2.84e-8 Resting heart rate; LUSC cis rs921968 0.541 rs687747 chr2:219399627 T/C cg02176678 chr2:219576539 TTLL4 0.74 14.55 0.62 1.7e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.51 7.72 0.39 1.36e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.79 0.39 8.76e-14 Parkinson's disease; LUSC trans rs6089829 0.962 rs4586690 chr20:61658595 G/T cg15934090 chr1:100435551 SLC35A3 0.47 7.72 0.39 1.4e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs9952991 0.941 rs2014857 chr18:12774326 C/T cg23598886 chr18:12777645 NA 0.65 6.58 0.34 1.83e-10 Inflammatory skin disease; LUSC cis rs1577917 0.958 rs12205492 chr6:86475976 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.8 -0.43 7.38e-17 Response to antipsychotic treatment; LUSC cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg12011299 chr4:100065546 ADH4 0.71 10.85 0.51 1.08e-23 Smoking initiation; LUSC cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 33.83 0.88 6.29e-110 Chronic sinus infection; LUSC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.69 0.3 2.71e-8 Personality dimensions; LUSC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg04450456 chr4:17643702 FAM184B 0.39 6.78 0.35 5.59e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7917772 0.582 rs10786682 chr10:104318322 A/C cg22532475 chr10:104410764 TRIM8 0.26 6.16 0.32 2.1e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg10018233 chr7:150070692 REPIN1 0.34 6.01 0.31 4.93e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17748167 chr1:31769917 ZCCHC17;SNRNP40 -0.53 -6.31 -0.33 8.79e-10 Bipolar disorder and schizophrenia; LUSC cis rs6977940 0.598 rs73033411 chr7:2881550 G/C cg14895029 chr7:2775587 GNA12 0.51 5.91 0.31 8.61e-9 White matter integrity; LUSC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg08773314 chr2:239334832 ASB1 0.42 9.26 0.45 2.6e-18 Multiple system atrophy; LUSC cis rs2276314 0.947 rs16967319 chr18:33573525 A/G cg05985134 chr18:33552581 C18orf21 0.51 6.86 0.35 3.43e-11 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs1493916 0.748 rs34501189 chr18:31314196 A/G cg13755796 chr4:20253514 NA -0.39 -6.06 -0.31 3.75e-9 Life satisfaction; LUSC cis rs77633900 0.892 rs4489970 chr15:76631027 A/G cg21673338 chr15:77095150 SCAPER 0.62 5.74 0.3 2.12e-8 Non-glioblastoma glioma;Glioma; LUSC cis rs3008870 1.000 rs2985818 chr1:67398916 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.15 0.64 7.62e-40 Lymphocyte percentage of white cells; LUSC cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.27 -0.45 2.39e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg00321850 chr1:175162397 KIAA0040 0.44 7.63 0.39 2.46e-13 Alcohol dependence; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg26218726 chr12:122018391 KDM2B 0.42 6.17 0.32 1.94e-9 N-glycan levels; LUSC cis rs12618769 0.543 rs72819980 chr2:99040522 A/G cg10123293 chr2:99228465 UNC50 0.45 7.64 0.39 2.31e-13 Bipolar disorder; LUSC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.75 0.39 1.1e-13 Crohn's disease; LUSC cis rs925255 0.743 rs7589485 chr2:28645120 C/A cg01273330 chr2:28605224 NA -0.38 -6.13 -0.32 2.46e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11191270 0.554 rs10444022 chr10:104084889 A/G cg15320455 chr10:103880129 LDB1 0.58 6.0 0.31 5.22e-9 Intelligence (multi-trait analysis); LUSC trans rs12579753 0.833 rs1922566 chr12:82135030 T/C cg07923666 chr12:49932857 KCNH3 -0.53 -6.56 -0.34 2.05e-10 Resting heart rate; LUSC cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.46 -8.46 -0.42 8.3e-16 Monocyte percentage of white cells; LUSC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.67 8.05 0.4 1.44e-14 Lung function (FEV1/FVC); LUSC cis rs295140 1.000 rs13005573 chr2:201164696 G/C cg04283868 chr2:201171347 SPATS2L 0.44 6.63 0.34 1.36e-10 QT interval; LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg08109568 chr15:31115862 NA -0.74 -11.09 -0.52 1.47e-24 Huntington's disease progression; LUSC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.05 0.52 2.07e-24 Hip circumference adjusted for BMI; LUSC cis rs4295623 0.789 rs12541318 chr8:11594970 G/T cg00262122 chr8:11665843 FDFT1 -0.41 -6.11 -0.32 2.73e-9 Morning vs. evening chronotype; LUSC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg23982607 chr1:1823379 GNB1 -0.73 -15.01 -0.63 2.78e-39 Body mass index; LUSC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg18654377 chr3:49208889 KLHDC8B -0.5 -6.68 -0.34 9.86e-11 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs8060686 0.641 rs76419201 chr16:68153553 G/A cg05110241 chr16:68378359 PRMT7 -0.58 -6.62 -0.34 1.41e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg05768032 chr16:30646687 NA 0.42 6.2 0.32 1.63e-9 Multiple myeloma; LUSC cis rs9326248 0.861 rs4938352 chr11:117027481 G/A cg16524733 chr11:117070046 TAGLN 0.36 5.71 0.3 2.47e-8 Blood protein levels; LUSC cis rs6456156 0.805 rs6909252 chr6:167527097 C/T cg07741184 chr6:167504864 NA -0.35 -6.15 -0.32 2.18e-9 Primary biliary cholangitis; LUSC cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg23711669 chr6:146136114 FBXO30 0.88 16.1 0.66 1.48e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.52 -7.2 -0.37 4.11e-12 Tonsillectomy; LUSC cis rs1801251 0.896 rs79793315 chr2:233690864 C/T cg08000102 chr2:233561755 GIGYF2 -0.66 -10.77 -0.51 1.99e-23 Coronary artery disease; LUSC cis rs7179456 0.513 rs593742 chr15:59045774 A/G cg05156742 chr15:59063176 FAM63B 0.48 6.97 0.36 1.69e-11 Asperger disorder; LUSC cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg18252515 chr7:66147081 NA -1.22 -14.14 -0.61 6.82e-36 Diabetic kidney disease; LUSC cis rs62400317 0.859 rs6927213 chr6:45206283 A/G cg20913747 chr6:44695427 NA 0.42 6.04 0.31 4.13e-9 Total body bone mineral density; LUSC cis rs4727027 0.899 rs6944096 chr7:148870026 A/G cg23158103 chr7:148848205 ZNF398 -0.5 -8.11 -0.41 9.69e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs7581030 0.527 rs4852252 chr2:71539301 T/C cg06465196 chr4:154387603 KIAA0922 0.41 5.96 0.31 6.45e-9 Testicular germ cell tumor; LUSC cis rs9527 0.615 rs12248123 chr10:104735366 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.57 -0.34 1.92e-10 Arsenic metabolism; LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg13560548 chr3:10150139 C3orf24 0.52 7.07 0.36 8.87e-12 Alzheimer's disease; LUSC cis rs9467711 0.651 rs16891264 chr6:26072445 C/T cg21479132 chr6:26055353 NA -0.62 -5.77 -0.3 1.81e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs11098499 0.754 rs66900435 chr4:120249425 C/A cg24375607 chr4:120327624 NA 0.75 12.07 0.55 4.56e-28 Corneal astigmatism; LUSC cis rs9650657 0.707 rs4841452 chr8:10687121 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.21 -0.32 1.62e-9 Neuroticism; LUSC cis rs62458065 0.513 rs702831 chr7:32579715 C/T cg20159608 chr7:32802032 NA -0.7 -9.09 -0.45 8.7e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg20283391 chr11:68216788 NA -0.57 -8.13 -0.41 8.28e-15 Total body bone mineral density; LUSC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.21 0.45 3.73e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9640161 0.830 rs17173703 chr7:150068620 C/T cg17279839 chr7:150038598 RARRES2 0.39 5.86 0.31 1.12e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg06915202 chr7:98029285 BAIAP2L1 0.31 6.19 0.32 1.73e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7503807 1.000 rs7503807 chr17:78591111 G/T cg09596252 chr17:78655493 RPTOR -0.44 -7.62 -0.38 2.67e-13 Obesity; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11802172 chr6:36953962 MTCH1 -0.43 -6.35 -0.33 7.05e-10 Electrocardiographic conduction measures; LUSC trans rs12579753 1.000 rs7306395 chr12:82175867 A/G cg07923666 chr12:49932857 KCNH3 -0.5 -6.15 -0.32 2.25e-9 Resting heart rate; LUSC cis rs1568889 1.000 rs12287732 chr11:28120845 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 9.47 0.46 5.23e-19 Bipolar disorder; LUSC cis rs73198271 0.960 rs73198290 chr8:8616009 A/T cg15556689 chr8:8085844 FLJ10661 -0.48 -5.84 -0.3 1.26e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.91 -0.44 3.36e-17 Breast cancer; LUSC cis rs4319547 0.737 rs4758646 chr12:122946507 G/A cg23029597 chr12:123009494 RSRC2 -0.62 -8.08 -0.4 1.17e-14 Body mass index; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg11905131 chr22:24372483 LOC391322 -0.58 -9.66 -0.47 1.27e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg18350739 chr11:68623251 NA -0.41 -7.19 -0.37 4.39e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11890956 chr21:40555474 PSMG1 -0.88 -15.62 -0.65 1.12e-41 Cognitive function; LUSC cis rs8114671 0.773 rs3746438 chr20:33584289 C/T cg07148914 chr20:33460835 GGT7 -0.42 -6.09 -0.32 3.06e-9 Height; LUSC cis rs6558174 0.630 rs6558176 chr8:22522502 C/T cg03733263 chr8:22462867 KIAA1967 -0.5 -6.48 -0.33 3.24e-10 Breast cancer; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.7 -11.81 -0.54 3.88e-27 Prudent dietary pattern; LUSC cis rs2377585 0.563 rs11046832 chr12:8847970 T/G cg03761649 chr12:8850719 RIMKLB 0.46 6.23 0.32 1.39e-9 Reticulocyte fraction of red cells; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25338204 chr5:175955105 RNF44 -0.38 -5.97 -0.31 6.03e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.4 0.38 1.14e-12 Motion sickness; LUSC cis rs11030122 0.645 rs11493482 chr11:4034772 A/G cg08557956 chr11:4115526 RRM1 -0.47 -5.97 -0.31 6.08e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs4969178 0.965 rs12450500 chr17:76395750 C/T cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC trans rs11186 0.556 rs7419288 chr2:189950871 C/T cg18242712 chr11:20182324 DBX1 -0.52 -6.15 -0.32 2.18e-9 Parkinson's disease; LUSC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg17971929 chr21:40555470 PSMG1 -0.5 -7.41 -0.38 1.01e-12 Menarche (age at onset); LUSC cis rs2463822 0.920 rs11828383 chr11:62067818 C/T cg06239285 chr11:62104954 ASRGL1 -0.89 -8.46 -0.42 8.58e-16 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs8072100 0.748 rs9908016 chr17:45551361 G/A cg03886242 chr7:26192032 NFE2L3 -0.42 -6.66 -0.34 1.1e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg25025879 chr12:53359317 NA -0.54 -8.17 -0.41 6.44e-15 Cancer (pleiotropy); LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg08219700 chr8:58056026 NA 0.7 7.95 0.4 2.95e-14 Developmental language disorder (linguistic errors); LUSC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg23172400 chr8:95962367 TP53INP1 0.3 5.95 0.31 6.71e-9 Type 2 diabetes; LUSC cis rs9549260 0.620 rs4325427 chr13:41216534 C/T cg21288729 chr13:41239152 FOXO1 0.58 8.88 0.44 4.03e-17 Red blood cell count; LUSC cis rs11098499 0.913 rs11098496 chr4:120167466 C/G cg09307838 chr4:120376055 NA 0.69 9.98 0.48 1.05e-20 Corneal astigmatism; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg07167872 chr1:205819463 PM20D1 0.98 22.85 0.78 3.06e-70 Menarche (age at onset); LUSC cis rs9902453 0.619 rs1038088 chr17:28074563 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.76 -0.51 2.21e-23 Coffee consumption (cups per day); LUSC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg23093090 chr10:104574429 C10orf26 -0.37 -6.95 -0.36 1.93e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg26380479 chr7:97908229 NA -0.27 -6.14 -0.32 2.28e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10740039 0.516 rs1442549 chr10:62334300 C/T cg18175470 chr10:62150864 ANK3 -0.45 -6.81 -0.35 4.41e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs35000415 0.938 rs13227075 chr7:128643297 T/C cg19972273 chr7:128594194 NA 0.68 6.79 0.35 5.04e-11 Systemic lupus erythematosus; LUSC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg00784671 chr22:46762841 CELSR1 -0.71 -7.58 -0.38 3.53e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs2274273 0.967 rs67756714 chr14:55589823 G/A cg04306507 chr14:55594613 LGALS3 0.53 11.61 0.54 2e-26 Protein biomarker; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg10802521 chr3:52805072 NEK4 -0.46 -7.3 -0.37 2.18e-12 Electroencephalogram traits; LUSC cis rs8099014 1.000 rs3744868 chr18:56123059 C/T cg12907477 chr18:56117327 MIR122 0.43 6.84 0.35 3.84e-11 Platelet count; LUSC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg22875332 chr1:76189707 ACADM -0.76 -10.36 -0.49 5.26e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6465657 0.903 rs11767962 chr7:97778576 C/T cg24562669 chr7:97807699 LMTK2 0.48 8.64 0.43 2.31e-16 Prostate cancer (SNP x SNP interaction);Prostate cancer; LUSC cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg13010199 chr12:38710504 ALG10B 0.46 7.13 0.36 6.3e-12 Heart rate; LUSC cis rs2274273 0.901 rs17674563 chr14:55831125 G/A cg04306507 chr14:55594613 LGALS3 0.54 11.8 0.54 4.35e-27 Protein biomarker; LUSC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.16 -0.41 6.84e-15 Height; LUSC cis rs6504340 0.739 rs4793939 chr17:46665235 G/A cg09704116 chr17:46666958 LOC404266 -0.37 -5.73 -0.3 2.22e-8 Primary tooth development (number of teeth); LUSC cis rs10484885 0.824 rs112817281 chr6:90555658 G/A cg13799429 chr6:90582589 CASP8AP2 -0.83 -8.16 -0.41 6.94e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4604732 0.588 rs7552461 chr1:247628644 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.78 0.35 5.42e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9457247 0.765 rs9295385 chr6:167448181 A/G cg07741184 chr6:167504864 NA 0.4 6.53 0.34 2.51e-10 Crohn's disease; LUSC cis rs56399783 0.708 rs56208415 chr7:2813806 G/A cg14895029 chr7:2775587 GNA12 0.47 5.82 0.3 1.41e-8 Childhood ear infection; LUSC cis rs936229 0.798 rs1869959 chr15:75147332 A/C cg10253484 chr15:75165896 SCAMP2 -0.57 -7.5 -0.38 5.66e-13 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs941898 0.836 rs8016001 chr14:100598691 A/G cg26002632 chr14:100625216 DEGS2 -0.34 -6.64 -0.34 1.29e-10 White matter hyperintensity burden; LUSC cis rs12681288 0.676 rs6983981 chr8:1016011 A/C cg15309053 chr8:964076 NA 0.38 7.57 0.38 3.64e-13 Schizophrenia; LUSC cis rs4073582 0.595 rs708471 chr11:65931008 A/G cg14036092 chr11:66035641 RAB1B 0.41 5.81 0.3 1.49e-8 Gout; LUSC cis rs7588746 0.621 rs1816541 chr2:201151011 T/C cg23649088 chr2:200775458 C2orf69 -0.42 -5.91 -0.31 8.36e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.49 8.08 0.4 1.23e-14 Menarche (age at onset); LUSC cis rs7827545 1.000 rs4909909 chr8:135564627 T/C cg17885191 chr8:135476712 NA 0.56 8.32 0.41 2.34e-15 Hypertension (SNP x SNP interaction); LUSC cis rs35995292 0.500 rs7776996 chr7:38919762 G/C cg19327137 chr7:38886074 VPS41 0.55 10.26 0.49 1.21e-21 Subjective well-being (multi-trait analysis); LUSC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg06637938 chr14:75390232 RPS6KL1 0.51 7.86 0.4 5.32e-14 Height; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg12432903 chr7:1882776 MAD1L1 -0.5 -8.57 -0.42 3.87e-16 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg20887711 chr4:1340912 KIAA1530 0.47 7.24 0.37 3.14e-12 Obesity-related traits; LUSC cis rs3020736 0.500 rs6002603 chr22:42492362 C/G cg15557168 chr22:42548783 NA 0.46 7.12 0.36 6.7e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs2279817 0.780 rs35588575 chr1:18007045 A/G cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.2 -0.32 1.71e-9 Neuroticism; LUSC cis rs2290416 0.892 rs62523607 chr8:144667432 G/A cg08017634 chr8:144659831 NAPRT1 0.72 6.12 0.32 2.59e-9 Attention deficit hyperactivity disorder; LUSC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg16797656 chr11:68205561 LRP5 0.4 7.15 0.36 5.54e-12 Total body bone mineral density; LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg01802117 chr1:53393560 SCP2 -0.37 -6.13 -0.32 2.52e-9 Monocyte count; LUSC cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg26384229 chr12:38710491 ALG10B 0.88 15.14 0.64 8.97e-40 Bladder cancer; LUSC cis rs12760731 0.720 rs12755909 chr1:178305298 G/A cg00404053 chr1:178313656 RASAL2 0.6 6.34 0.33 7.4e-10 Obesity-related traits; LUSC cis rs10761482 0.500 rs1892546 chr10:62294016 T/G cg18175470 chr10:62150864 ANK3 -0.5 -7.24 -0.37 3.11e-12 Schizophrenia; LUSC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg22823121 chr1:150693482 HORMAD1 0.58 8.88 0.44 4.07e-17 Tonsillectomy; LUSC cis rs782590 0.967 rs782586 chr2:55836165 A/C cg03859395 chr2:55845619 SMEK2 0.88 16.66 0.67 8.58e-46 Metabolic syndrome; LUSC cis rs7681423 1.000 rs7654093 chr4:155545072 A/T cg20735720 chr4:155535218 FGG -0.49 -7.25 -0.37 2.95e-12 Fibrinogen; LUSC cis rs4474465 1.000 rs7928933 chr11:78193921 T/C cg27205649 chr11:78285834 NARS2 -0.5 -5.88 -0.31 1.01e-8 Alzheimer's disease (survival time); LUSC cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg05340658 chr4:99064831 C4orf37 0.68 11.57 0.53 2.91e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24983561 chr5:54603725 DHX29;SKIV2L2 -0.42 -6.08 -0.32 3.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7937682 0.889 rs493865 chr11:111495178 A/C cg18187862 chr3:45730750 SACM1L 0.54 7.05 0.36 1.05e-11 Primary sclerosing cholangitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20809690 chr4:2757764 TNIP2 -0.48 -6.11 -0.32 2.81e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg04871131 chr7:94954202 PON1 -0.39 -6.13 -0.32 2.44e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg19920283 chr7:105172520 RINT1 0.59 6.02 0.31 4.72e-9 Bipolar disorder (body mass index interaction); LUSC cis rs965604 0.965 rs4299116 chr15:78766194 T/A cg18825076 chr15:78729989 IREB2 -0.42 -6.83 -0.35 3.99e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg21724239 chr8:58056113 NA 0.75 8.4 0.42 1.27e-15 Developmental language disorder (linguistic errors); LUSC cis rs6840360 0.615 rs1561916 chr4:152479234 C/T cg22705602 chr4:152727874 NA -0.32 -6.38 -0.33 6.04e-10 Intelligence (multi-trait analysis); LUSC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg09323728 chr8:95962352 TP53INP1 -0.39 -7.76 -0.39 1.03e-13 Type 2 diabetes; LUSC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg24675658 chr1:53192096 ZYG11B 0.65 10.7 0.51 3.57e-23 Monocyte count; LUSC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.09 0.32 3.1e-9 Personality dimensions; LUSC cis rs7772486 0.840 rs854144 chr6:146360880 G/T cg23711669 chr6:146136114 FBXO30 -0.64 -9.55 -0.46 2.81e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg05347473 chr6:146136440 FBXO30 0.53 8.82 0.43 6.31e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC trans rs7618501 0.602 rs9311446 chr3:50092226 G/A cg21659725 chr3:3221576 CRBN -0.64 -10.62 -0.5 7.1e-23 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.84 -0.57 5.96e-31 Platelet count; LUSC cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.66 -0.6 4.79e-34 Chronic sinus infection; LUSC cis rs11098499 0.955 rs1511015 chr4:120170473 A/C cg09307838 chr4:120376055 NA 0.69 9.98 0.48 1.05e-20 Corneal astigmatism; LUSC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg24829409 chr8:58192753 C8orf71 -0.45 -5.65 -0.3 3.37e-8 Developmental language disorder (linguistic errors); LUSC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.74 10.72 0.51 3.01e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7188861 0.813 rs2867936 chr16:11398698 C/T cg00044050 chr16:11439710 C16orf75 0.54 5.9 0.31 8.71e-9 HDL cholesterol; LUSC cis rs1800795 0.901 rs2069833 chr7:22767664 C/T cg05472934 chr7:22766657 IL6 0.54 8.46 0.42 8.54e-16 Cerebrospinal fluid clusterin levels in APOEe4- carriers; LUSC trans rs10506458 0.834 rs58821476 chr12:63389425 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.07 -0.64 1.64e-39 Hemostatic factors and hematological phenotypes; LUSC trans rs9409154 0.617 rs7470135 chr9:118394038 T/C cg06386307 chr6:100895211 SIM1 0.35 6.26 0.32 1.19e-9 Visceral adipose tissue adjusted for BMI; LUSC trans rs236907 0.859 rs7536142 chr1:171770336 A/G cg13482142 chr2:234261155 NA 0.5 6.16 0.32 2.07e-9 Mean platelet volume; LUSC cis rs59918340 0.764 rs10107024 chr8:142227592 T/C cg23750338 chr8:142222470 SLC45A4 0.58 11.26 0.52 3.94e-25 Immature fraction of reticulocytes; LUSC cis rs2629540 0.765 rs4962687 chr10:126404141 G/A cg08799069 chr10:126477246 METTL10 -0.48 -7.41 -0.38 1.06e-12 Cocaine dependence; LUSC cis rs227833 0.729 rs687878 chr6:44706790 T/C cg20913747 chr6:44695427 NA 0.38 6.04 0.31 4.13e-9 Monobrow; LUSC cis rs6963495 0.745 rs73192150 chr7:105211610 A/C cg19920283 chr7:105172520 RINT1 0.58 5.94 0.31 7.27e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg16447950 chr5:562315 NA -0.54 -7.65 -0.39 2.18e-13 Obesity-related traits; LUSC cis rs17818399 0.708 rs1531133 chr2:46843631 A/G cg02822958 chr2:46747628 ATP6V1E2 0.36 6.1 0.32 3e-9 Height; LUSC cis rs6060717 0.536 rs11167279 chr20:34509107 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.74 -0.3 2.13e-8 Hip circumference adjusted for BMI; LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.05 0.64 1.94e-39 Platelet count; LUSC cis rs317689 0.690 rs607797 chr12:69646010 T/C cg20891283 chr12:69753455 YEATS4 0.43 5.78 0.3 1.67e-8 Response to diuretic therapy; LUSC cis rs2073300 1.000 rs78000067 chr20:23439507 A/G cg09953122 chr20:23471693 CST8 -0.93 -7.37 -0.37 1.32e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs7618501 0.540 rs11130241 chr3:50131459 A/T cg21659725 chr3:3221576 CRBN -0.65 -10.56 -0.5 1.07e-22 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.626 rs9870858 chr3:49769071 C/T cg03060546 chr3:49711283 APEH 0.64 7.69 0.39 1.67e-13 Menarche (age at onset); LUSC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg08847533 chr14:75593920 NEK9 -0.82 -14.81 -0.63 1.74e-38 Height; LUSC trans rs11039798 0.764 rs4357721 chr11:48354907 G/A cg15704280 chr7:45808275 SEPT13 -0.7 -6.61 -0.34 1.55e-10 Axial length; LUSC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg13319975 chr6:146136371 FBXO30 -0.72 -11.26 -0.52 3.93e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg11494091 chr17:61959527 GH2 0.65 13.29 0.59 1.22e-32 Prudent dietary pattern; LUSC cis rs11711311 1.000 rs62268168 chr3:113489447 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.81 -0.3 1.49e-8 IgG glycosylation; LUSC cis rs7512552 0.803 rs11205385 chr1:150476516 G/A cg15654264 chr1:150340011 RPRD2 0.65 10.68 0.5 4.27e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08704250 chr15:31115839 NA -0.48 -7.12 -0.36 6.63e-12 Huntington's disease progression; LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg26314531 chr2:26401878 FAM59B -0.71 -9.73 -0.47 7.57e-20 Gut microbiome composition (summer); LUSC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg00074818 chr8:8560427 CLDN23 0.58 9.74 0.47 7e-20 Obesity-related traits; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg22638593 chr5:131593259 PDLIM4 0.41 6.54 0.34 2.36e-10 Blood metabolite levels; LUSC cis rs2625529 0.586 rs7170456 chr15:72469946 G/C cg16672083 chr15:72433130 SENP8 0.48 8.0 0.4 2.14e-14 Red blood cell count; LUSC trans rs11610422 1.000 rs11610422 chr12:31412669 C/T cg02734259 chr12:9559402 NA 0.54 6.01 0.31 4.77e-9 Coronary artery disease; LUSC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg05340658 chr4:99064831 C4orf37 0.65 10.99 0.52 3.31e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.913 rs4988291 chr11:68381607 G/A cg16797656 chr11:68205561 LRP5 0.38 6.19 0.32 1.77e-9 Total body bone mineral density; LUSC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg02788857 chr8:22132959 PIWIL2 -0.37 -7.36 -0.37 1.48e-12 Hypertriglyceridemia; LUSC cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs240764 0.817 rs239190 chr6:101129067 C/T cg09795085 chr6:101329169 ASCC3 0.42 6.11 0.32 2.83e-9 Neuroticism; LUSC cis rs2742417 0.935 rs2248991 chr3:45754749 G/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18929903 chr10:101418993 ENTPD7 -0.41 -6.05 -0.31 3.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9325144 0.647 rs12822023 chr12:39097964 T/C cg26384229 chr12:38710491 ALG10B -0.62 -9.68 -0.47 1.06e-19 Morning vs. evening chronotype; LUSC cis rs9837602 1.000 rs4279135 chr3:99733096 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.09 -0.32 3.14e-9 Breast cancer; LUSC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg15556689 chr8:8085844 FLJ10661 -0.88 -16.27 -0.66 3.04e-44 Neuroticism; LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg13395646 chr4:1353034 KIAA1530 -0.59 -8.45 -0.42 9.09e-16 Longevity; LUSC trans rs61931739 0.517 rs11053224 chr12:34484919 G/A cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.87e-21 Morning vs. evening chronotype; LUSC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg23172400 chr8:95962367 TP53INP1 -0.39 -8.25 -0.41 3.73e-15 Type 2 diabetes; LUSC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg17179660 chr6:151773299 C6orf211;RMND1 0.5 6.87 0.35 3.17e-11 Menarche (age at onset); LUSC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg14019146 chr3:50243930 SLC38A3 -0.33 -7.33 -0.37 1.73e-12 Intelligence (multi-trait analysis); LUSC cis rs12618769 0.597 rs10496327 chr2:99066827 A/G cg10123293 chr2:99228465 UNC50 0.45 7.39 0.37 1.19e-12 Bipolar disorder; LUSC trans rs9291683 0.588 rs35438220 chr4:9999398 C/T cg26043149 chr18:55253948 FECH 0.48 6.99 0.36 1.48e-11 Bone mineral density; LUSC trans rs3960554 0.808 rs112962015 chr7:75659303 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 9.66 0.47 1.22e-19 Eotaxin levels; LUSC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg11843238 chr5:131593191 PDLIM4 -0.39 -6.31 -0.33 8.96e-10 Breast cancer; LUSC trans rs2248359 0.770 rs2208588 chr20:52796971 A/T cg01847206 chr5:14165995 TRIO -0.35 -6.07 -0.32 3.44e-9 Multiple sclerosis; LUSC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.18 -0.32 1.82e-9 Total body bone mineral density; LUSC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg03433033 chr1:76189801 ACADM -0.82 -13.06 -0.58 9.04e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg26408565 chr15:76604113 ETFA -0.44 -6.94 -0.36 2.03e-11 Blood metabolite levels; LUSC cis rs10197940 0.510 rs7602715 chr2:152421937 A/G cg06191203 chr2:152266755 RIF1 -0.56 -7.32 -0.37 1.81e-12 Lung cancer; LUSC cis rs61931739 0.890 rs1705750 chr12:34142648 C/T cg06521331 chr12:34319734 NA -0.35 -5.99 -0.31 5.57e-9 Morning vs. evening chronotype; LUSC cis rs9399135 0.967 rs9402676 chr6:135355507 C/T cg22676075 chr6:135203613 NA 0.46 7.27 0.37 2.56e-12 Red blood cell count; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg13560548 chr3:10150139 C3orf24 0.51 7.29 0.37 2.19e-12 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07550334 chr14:75518271 MLH3 0.42 6.24 0.32 1.34e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1814175 0.654 rs7482446 chr11:49779020 A/G cg03929089 chr4:120376271 NA -1.01 -18.85 -0.72 1.71e-54 Height; LUSC cis rs61931739 0.857 rs1828514 chr12:34139600 A/G cg06521331 chr12:34319734 NA -0.37 -6.32 -0.33 8.26e-10 Morning vs. evening chronotype; LUSC cis rs68170813 0.559 rs2299422 chr7:106959832 A/T cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.73 -0.3 2.3e-8 Coronary artery disease; LUSC cis rs7215564 0.818 rs901063 chr17:78595696 A/T cg09596252 chr17:78655493 RPTOR -0.53 -5.81 -0.3 1.44e-8 Myopia (pathological); LUSC cis rs6939532 0.522 rs9366652 chr6:26354219 C/G cg05738196 chr6:26577821 NA -0.43 -6.16 -0.32 2.11e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs4343996 0.869 rs6651070 chr7:3465411 G/C cg21248987 chr7:3385318 SDK1 0.37 6.19 0.32 1.79e-9 Motion sickness; LUSC cis rs6752107 1.000 rs2241879 chr2:234183468 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.78 0.54 4.92e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9527 0.545 rs35756290 chr10:104585572 G/A cg04362960 chr10:104952993 NT5C2 0.66 9.13 0.45 6.81e-18 Arsenic metabolism; LUSC cis rs2346177 0.605 rs7556828 chr2:46663172 A/G cg26688816 chr2:46740690 ATP6V1E2 0.64 10.47 0.5 2.18e-22 HDL cholesterol; LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs734999 0.588 rs867435 chr1:2523706 C/T cg18854424 chr1:2615690 NA 0.48 9.36 0.46 1.24e-18 Ulcerative colitis; LUSC cis rs1609391 0.543 rs1347209 chr3:136626697 G/T cg15507776 chr3:136538369 TMEM22 0.5 8.25 0.41 3.79e-15 Neuroticism; LUSC cis rs6469656 1.000 rs3088140 chr8:117786603 T/C cg24004040 chr8:117650383 NA 0.41 5.65 0.3 3.51e-8 Colorectal cancer; LUSC cis rs6066835 0.702 rs6095228 chr20:47279876 A/G cg18078177 chr20:47281410 PREX1 -0.68 -5.7 -0.3 2.63e-8 Multiple myeloma; LUSC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg05623727 chr3:50126028 RBM5 -0.33 -6.26 -0.32 1.16e-9 Body mass index; LUSC cis rs2948294 0.545 rs11776397 chr8:8115161 C/T cg15556689 chr8:8085844 FLJ10661 0.72 9.96 0.48 1.25e-20 Red cell distribution width; LUSC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg15704280 chr7:45808275 SEPT13 -1.02 -19.49 -0.73 4.84e-57 Height; LUSC cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg19628046 chr18:33552617 C18orf21 0.5 6.11 0.32 2.83e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs12891047 0.804 rs10135927 chr14:68313209 G/A cg20999565 chr14:68265668 ZFYVE26 0.38 5.85 0.3 1.18e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2303282 0.726 rs4541073 chr16:56451900 C/T cg00500540 chr16:56394104 NA -0.43 -7.37 -0.37 1.37e-12 Breast cancer; LUSC cis rs870825 0.616 rs28618216 chr4:185648998 T/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg24692254 chr21:30365293 RNF160 0.91 18.54 0.71 3.03e-53 Dental caries; LUSC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9549367 0.789 rs3861720 chr13:113906097 A/G cg18105134 chr13:113819100 PROZ -0.68 -9.66 -0.47 1.24e-19 Platelet distribution width; LUSC cis rs7089973 0.604 rs765174 chr10:116601888 C/T cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs354225 0.544 rs4616509 chr2:54807982 T/C cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs2762353 0.845 rs35720558 chr6:25784800 A/C cg03517284 chr6:25882590 NA 0.44 7.78 0.39 9.2e-14 Blood metabolite levels; LUSC cis rs7208859 0.623 rs8067338 chr17:29102345 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2708977 0.899 rs12992413 chr2:97277489 A/G cg01950434 chr2:97203154 ARID5A 0.58 8.83 0.44 5.93e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg27572855 chr1:25598939 RHD 0.43 7.78 0.39 9.24e-14 Erythrocyte sedimentation rate; LUSC cis rs12421382 0.881 rs1808843 chr11:109389471 A/G cg16359550 chr11:109292809 C11orf87 0.41 7.18 0.37 4.64e-12 Schizophrenia; LUSC cis rs3126085 0.935 rs55942250 chr1:152251914 G/A cg26876637 chr1:152193138 HRNR -0.43 -5.69 -0.3 2.85e-8 Atopic dermatitis; LUSC cis rs2970818 0.831 rs10849083 chr12:4642572 G/T cg11146114 chr12:4671731 NA -0.57 -6.06 -0.31 3.63e-9 Phosphorus levels; LUSC cis rs1348850 0.846 rs4893962 chr2:178421106 A/G cg22681709 chr2:178499509 PDE11A -0.47 -8.44 -0.42 9.78e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg12963246 chr6:28129442 ZNF389 0.53 7.41 0.38 1.04e-12 Parkinson's disease; LUSC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg01657329 chr11:68192670 LRP5 0.48 7.84 0.39 6.22e-14 Total body bone mineral density; LUSC cis rs5769707 0.521 rs9616715 chr22:50058582 C/T cg10356904 chr22:49881777 NA -0.3 -5.94 -0.31 7.14e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.44 7.04 0.36 1.08e-11 Vitiligo; LUSC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.56 -0.34 2.05e-10 Lung cancer; LUSC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg02891314 chr5:179741120 GFPT2 -0.63 -10.26 -0.49 1.19e-21 Height; LUSC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg17366294 chr4:99064904 C4orf37 0.57 9.91 0.48 1.76e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4356932 1.000 rs6844097 chr4:76950757 T/C cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.59e-8 Blood protein levels; LUSC cis rs9894429 0.624 rs9910935 chr17:79613949 T/C cg21984481 chr17:79567631 NPLOC4 -0.69 -13.85 -0.6 8.44e-35 Eye color traits; LUSC cis rs3764021 0.868 rs7306304 chr12:9877196 G/A cg20894963 chr12:9885564 CLECL1 0.35 7.1 0.36 7.47e-12 Type 1 diabetes; LUSC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg18827107 chr12:86230957 RASSF9 -0.5 -7.29 -0.37 2.32e-12 Major depressive disorder; LUSC cis rs7617773 0.832 rs6775114 chr3:48182620 G/C cg20734569 chr3:48348370 SPINK8 0.45 8.23 0.41 4.14e-15 Coronary artery disease; LUSC cis rs2832077 0.943 rs2832100 chr21:30175628 A/C cg08807101 chr21:30365312 RNF160 -0.47 -6.08 -0.32 3.37e-9 Cognitive test performance; LUSC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg16339924 chr4:17578868 LAP3 0.64 10.13 0.48 3.35e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg11247378 chr22:39784982 NA -0.63 -12.21 -0.56 1.34e-28 Intelligence (multi-trait analysis); LUSC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg14416269 chr4:6271139 WFS1 0.49 9.78 0.47 5.09e-20 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2742417 0.603 rs2531755 chr3:45772742 T/C cg04837898 chr3:45731254 SACM1L -0.45 -7.25 -0.37 2.97e-12 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs9329221 0.576 rs1986972 chr8:10268805 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.91 0.35 2.54e-11 Neuroticism; LUSC cis rs9527 0.662 rs10786714 chr10:104598606 G/C cg05855489 chr10:104503620 C10orf26 0.62 8.74 0.43 1.15e-16 Arsenic metabolism; LUSC cis rs9393777 0.623 rs2093169 chr6:26495099 C/T cg09904177 chr6:26538194 HMGN4 -0.52 -5.81 -0.3 1.45e-8 Intelligence (multi-trait analysis); LUSC cis rs1965732 0.917 rs9750735 chr2:3708383 A/T cg19052272 chr2:3704530 ALLC -0.36 -6.79 -0.35 5.05e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9788721 0.934 rs1051730 chr15:78894339 G/A cg06917634 chr15:78832804 PSMA4 -0.43 -5.8 -0.3 1.51e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs11098499 0.644 rs7693919 chr4:120540571 G/A cg09307838 chr4:120376055 NA 0.64 9.52 0.46 3.54e-19 Corneal astigmatism; LUSC cis rs2625529 0.818 rs2246225 chr15:72115230 C/T cg16672083 chr15:72433130 SENP8 0.44 6.39 0.33 5.54e-10 Red blood cell count; LUSC trans rs7939886 0.688 rs11227290 chr11:55896577 A/G cg15704280 chr7:45808275 SEPT13 0.79 6.69 0.34 9.58e-11 Myopia (pathological); LUSC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg05802129 chr4:122689817 NA -0.51 -8.72 -0.43 1.38e-16 Type 2 diabetes; LUSC cis rs68170813 0.559 rs75932578 chr7:106844694 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.7 -0.47 9.45e-20 Coronary artery disease; LUSC cis rs2742417 1.000 rs2742422 chr3:45732820 G/A cg09608765 chr3:45636137 LIMD1 -0.36 -7.17 -0.37 4.82e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4631830 0.863 rs57263518 chr10:51519154 A/G cg20129853 chr10:51489980 NA -0.33 -6.61 -0.34 1.49e-10 Prostate-specific antigen levels; LUSC cis rs11098499 0.954 rs6848389 chr4:120402622 A/G cg24375607 chr4:120327624 NA 0.76 11.68 0.54 1.16e-26 Corneal astigmatism; LUSC cis rs8017423 0.967 rs4904656 chr14:90721442 G/T cg04374321 chr14:90722782 PSMC1 0.75 12.12 0.55 2.92e-28 Mortality in heart failure; LUSC cis rs3087591 1.000 rs2051506 chr17:29699860 T/A cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.02 -0.4 1.81e-14 Hip circumference; LUSC cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs1832871 0.711 rs9457264 chr6:158689367 G/A cg07165851 chr6:158734300 TULP4 0.5 7.79 0.39 8.78e-14 Height; LUSC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg15787769 chr11:842744 TSPAN4;POLR2L -0.53 -7.22 -0.37 3.47e-12 Mean platelet volume; LUSC cis rs454510 0.857 rs838990 chr1:120193252 A/G cg16322792 chr1:120165303 ZNF697 0.34 5.73 0.3 2.23e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg15147215 chr3:52552868 STAB1 -0.33 -6.51 -0.34 2.72e-10 Electroencephalogram traits; LUSC cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.97 0.44 2.18e-17 Motion sickness; LUSC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg00033643 chr7:134001901 SLC35B4 -0.44 -6.89 -0.35 2.82e-11 Mean platelet volume; LUSC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs6714710 0.580 rs11690737 chr2:98461953 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.5 0.42 6.32e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg15997130 chr1:24165203 NA -0.53 -8.85 -0.44 5.06e-17 Immature fraction of reticulocytes; LUSC cis rs56283067 0.578 rs12203052 chr6:45398958 C/G cg20913747 chr6:44695427 NA -0.41 -5.96 -0.31 6.53e-9 Total body bone mineral density; LUSC cis rs1941023 0.503 rs4939350 chr11:60136243 C/G cg08716584 chr11:60157161 MS4A7 -0.62 -11.64 -0.54 1.63e-26 Congenital heart disease (maternal effect); LUSC trans rs4650994 0.525 rs4650997 chr1:178530744 T/A cg05059571 chr16:84539110 KIAA1609 -0.48 -9.01 -0.44 1.57e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg21733973 chr7:65235735 NA -0.41 -6.0 -0.31 5.19e-9 Calcium levels; LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.99 0.58 1.69e-31 Alzheimer's disease; LUSC cis rs2806561 0.514 rs7414010 chr1:23543929 T/C cg19743168 chr1:23544995 NA 0.55 10.72 0.51 2.96e-23 Height; LUSC cis rs7766436 0.885 rs12111204 chr6:22578227 C/T cg13666174 chr6:22585274 NA -0.42 -5.71 -0.3 2.54e-8 Coronary artery disease; LUSC cis rs7432375 0.580 rs4678441 chr3:136532828 T/C cg15507776 chr3:136538369 TMEM22 0.44 7.37 0.37 1.34e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs10782582 0.609 rs1630587 chr1:76399787 T/C cg10523679 chr1:76189770 ACADM -0.44 -6.48 -0.33 3.26e-10 Daytime sleep phenotypes; LUSC trans rs561341 1.000 rs483301 chr17:30293398 G/T cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.6e-8 Morning vs. evening chronotype; LUSC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg11941060 chr3:133502564 NA -0.52 -7.84 -0.39 5.93e-14 Iron status biomarkers; LUSC cis rs9952991 0.943 rs9952753 chr18:12780463 A/C cg23544223 chr18:12777786 NA 0.58 6.15 0.32 2.18e-9 Inflammatory skin disease; LUSC cis rs754466 1.000 rs754466 chr10:79680434 A/T cg17075019 chr10:79541650 NA -0.6 -8.17 -0.41 6.55e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2073300 1.000 rs115730610 chr20:23442621 G/A cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs727505 1.000 rs7806680 chr7:124433079 G/A cg23710748 chr7:124431027 NA -0.4 -7.26 -0.37 2.78e-12 Lewy body disease; LUSC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg11764359 chr7:65958608 NA 0.8 13.63 0.6 5.87e-34 Aortic root size; LUSC cis rs7267979 0.932 rs928121 chr20:25534818 A/G cg03522245 chr20:25566470 NINL 0.38 6.19 0.32 1.74e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6545883 0.929 rs2600663 chr2:61540687 A/G cg15711740 chr2:61764176 XPO1 0.47 7.57 0.38 3.79e-13 Tuberculosis; LUSC cis rs881375 0.967 rs1930780 chr9:123686219 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.99 0.36 1.46e-11 Rheumatoid arthritis; LUSC trans rs459571 0.839 rs10993895 chr9:136887726 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 0.75 13.28 0.59 1.31e-32 Platelet distribution width; LUSC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg18876405 chr7:65276391 NA -0.56 -8.68 -0.43 1.77e-16 Aortic root size; LUSC cis rs4409675 0.576 rs6691656 chr1:28221130 C/G cg23691781 chr1:28212827 C1orf38 0.32 7.59 0.38 3.2e-13 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06966617 chr2:74406040 MOBKL1B -0.41 -6.02 -0.31 4.71e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6430585 0.528 rs309113 chr2:136737460 C/A cg07169764 chr2:136633963 MCM6 1.01 15.41 0.64 7.48e-41 Corneal structure; LUSC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg13393036 chr8:95962371 TP53INP1 -0.46 -9.9 -0.48 1.96e-20 Type 2 diabetes; LUSC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg22823121 chr1:150693482 HORMAD1 -0.59 -9.02 -0.44 1.5e-17 Tonsillectomy; LUSC cis rs11209002 0.614 rs12140736 chr1:67586671 T/C cg02640540 chr1:67518911 SLC35D1 0.59 8.13 0.41 8.21e-15 Crohn's disease; LUSC cis rs929354 0.742 rs2107863 chr7:156963731 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs9326248 0.559 rs609177 chr11:116770517 A/G cg01368799 chr11:117014884 PAFAH1B2 0.58 8.74 0.43 1.19e-16 Blood protein levels; LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg02018176 chr4:1364513 KIAA1530 0.71 12.61 0.57 4.25e-30 Longevity; LUSC cis rs2463822 0.669 rs72919480 chr11:62043133 G/A cg06239285 chr11:62104954 ASRGL1 -0.75 -7.26 -0.37 2.74e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9815354 0.812 rs73071239 chr3:41992610 C/A cg03022575 chr3:42003672 ULK4 0.85 8.86 0.44 4.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg11871910 chr12:69753446 YEATS4 0.71 11.97 0.55 1.05e-27 Blood protein levels; LUSC cis rs3755132 0.929 rs3770470 chr2:15770507 G/T cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg04352962 chr1:209979756 IRF6 0.53 6.2 0.32 1.68e-9 Cleft lip with or without cleft palate; LUSC cis rs11690935 0.589 rs6729945 chr2:172864695 C/G cg13550731 chr2:172543902 DYNC1I2 0.54 8.05 0.4 1.5e-14 Schizophrenia; LUSC trans rs62238980 0.521 rs733907 chr22:32462564 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC trans rs4332037 1.000 rs62442899 chr7:1948454 C/T cg10840412 chr1:235813424 GNG4 0.67 8.91 0.44 3.33e-17 Bipolar disorder; LUSC cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg07606381 chr6:8435919 SLC35B3 0.75 12.89 0.58 3.77e-31 Motion sickness; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg13685833 chr1:53393034 SCP2 0.39 5.88 0.31 1.01e-8 Monocyte count; LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.24 0.52 4.35e-25 Menopause (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08292968 chr12:111020671 PPTC7 -0.53 -6.52 -0.34 2.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg08280861 chr8:58055591 NA 0.54 6.5 0.34 2.96e-10 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.899 rs442834 chr20:25458096 A/G cg08601574 chr20:25228251 PYGB 0.41 6.25 0.32 1.22e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.67 14.94 0.63 5.16e-39 Hemoglobin concentration; LUSC trans rs11098499 0.865 rs10032158 chr4:120391632 C/T cg25214090 chr10:38739885 LOC399744 0.58 8.47 0.42 8.08e-16 Corneal astigmatism; LUSC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.82 0.47 3.7e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg09796270 chr17:17721594 SREBF1 -0.45 -7.84 -0.39 5.94e-14 Total body bone mineral density; LUSC cis rs2073300 1.000 rs12625804 chr20:23441981 G/A cg12062639 chr20:23401060 NAPB 0.78 6.04 0.31 4.01e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg03709012 chr19:19516395 GATAD2A 0.77 11.69 0.54 1.06e-26 Tonsillectomy; LUSC cis rs2988277 0.737 rs2949668 chr1:167434721 T/C cg22356347 chr1:167427500 CD247 -0.26 -6.06 -0.31 3.77e-9 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18425377 chr14:105167727 INF2 0.39 6.28 0.32 1.08e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs68170813 0.559 rs12536485 chr7:106978005 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.62 -0.47 1.71e-19 Coronary artery disease; LUSC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg12927641 chr6:109611667 NA -0.38 -6.4 -0.33 5.13e-10 Reticulocyte fraction of red cells; LUSC cis rs9837602 1.000 rs35669453 chr3:99766063 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.88 -0.31 1.02e-8 Breast cancer; LUSC cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs1865760 0.963 rs1540273 chr6:25924158 T/C cg16482183 chr6:26056742 HIST1H1C 0.44 6.52 0.34 2.67e-10 Height; LUSC cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg04455712 chr21:45112962 RRP1B 0.45 8.35 0.42 1.82e-15 Mean corpuscular volume; LUSC cis rs67072384 0.786 rs60497375 chr11:72452645 A/G cg04827223 chr11:72435913 ARAP1 -0.8 -7.39 -0.37 1.18e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs62400317 0.723 rs12196188 chr6:44976426 G/C cg20913747 chr6:44695427 NA -0.46 -7.23 -0.37 3.41e-12 Total body bone mineral density; LUSC cis rs61931739 0.534 rs10844800 chr12:34230734 A/G cg06521331 chr12:34319734 NA -0.46 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg19346786 chr7:2764209 NA -0.4 -7.13 -0.36 6.44e-12 Height; LUSC trans rs561341 0.609 rs7209493 chr17:30197323 A/G cg20587970 chr11:113659929 NA 0.83 9.83 0.47 3.45e-20 Hip circumference adjusted for BMI; LUSC cis rs9807841 0.592 rs2043304 chr19:10772112 T/C cg09936142 chr19:10668400 KRI1 -0.4 -6.44 -0.33 4.08e-10 Inflammatory skin disease; LUSC cis rs2067615 0.524 rs4964483 chr12:107099057 T/C cg15890332 chr12:107067104 RFX4 0.35 6.15 0.32 2.24e-9 Heart rate; LUSC cis rs911555 0.723 rs56227024 chr14:103861706 A/G cg24130564 chr14:104152367 KLC1 0.47 6.77 0.35 5.68e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg11062466 chr8:58055876 NA 0.64 7.88 0.4 4.55e-14 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg17385448 chr1:15911702 AGMAT 0.35 5.93 0.31 7.36e-9 Systolic blood pressure; LUSC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs921968 0.565 rs6436086 chr2:219640125 T/C cg02176678 chr2:219576539 TTLL4 -0.56 -9.81 -0.47 4.09e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.5 -6.46 -0.33 3.72e-10 Renal function-related traits (BUN); LUSC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg23283495 chr1:209979779 IRF6 0.75 9.51 0.46 3.86e-19 Cleft lip with or without cleft palate; LUSC cis rs796825 0.548 rs12494395 chr3:119987430 G/A cg21790991 chr3:120137480 FSTL1 -0.34 -6.1 -0.32 2.93e-9 HIV-1 susceptibility; LUSC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg18876405 chr7:65276391 NA -0.74 -13.34 -0.59 7.93e-33 Aortic root size; LUSC cis rs4908769 0.624 rs1763838 chr1:8473331 G/A cg00546117 chr1:8445545 RERE -0.3 -6.04 -0.31 4.18e-9 Allergy; LUSC cis rs1577917 0.958 rs1335442 chr6:86466692 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.92 -0.44 3.11e-17 Response to antipsychotic treatment; LUSC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg08847533 chr14:75593920 NEK9 0.84 15.43 0.65 6.51e-41 Height; LUSC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg12292205 chr6:26970375 C6orf41 0.51 8.54 0.42 4.91e-16 Schizophrenia; LUSC cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg23158103 chr7:148848205 ZNF398 -0.48 -8.0 -0.4 2.13e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs453301 0.571 rs2929305 chr8:9085217 G/A cg21775007 chr8:11205619 TDH -0.43 -6.18 -0.32 1.89e-9 Joint mobility (Beighton score); LUSC cis rs7264396 0.790 rs3787168 chr20:34233278 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.5 -0.46 4.06e-19 Total cholesterol levels; LUSC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg20887711 chr4:1340912 KIAA1530 0.51 7.95 0.4 2.89e-14 Longevity; LUSC cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg26384229 chr12:38710491 ALG10B 0.91 15.38 0.64 9.49e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg14541582 chr5:601475 NA -0.37 -5.8 -0.3 1.56e-8 Lung disease severity in cystic fibrosis; LUSC cis rs2742234 0.541 rs10899782 chr10:43736361 A/T cg07801480 chr10:43725741 RASGEF1A -0.4 -5.92 -0.31 8.07e-9 Hirschsprung disease; LUSC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg06219351 chr7:158114137 PTPRN2 -0.49 -8.81 -0.43 7.11e-17 Calcium levels; LUSC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg02423579 chr7:2872169 GNA12 -0.48 -6.69 -0.34 9.62e-11 Height; LUSC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg00049323 chr5:472564 LOC25845 -0.43 -6.71 -0.34 8.18e-11 Cystic fibrosis severity; LUSC cis rs807669 0.770 rs807458 chr22:19220648 G/T cg02655711 chr22:19163373 SLC25A1 0.45 8.11 0.41 9.82e-15 Metabolite levels; LUSC cis rs6728642 0.908 rs6576996 chr2:97623312 T/C cg26665480 chr2:98280029 ACTR1B -0.69 -6.14 -0.32 2.33e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg22920501 chr2:26401640 FAM59B -0.76 -10.62 -0.5 6.75e-23 Gut microbiome composition (summer); LUSC cis rs5758659 0.594 rs739292 chr22:42368857 G/A cg04733989 chr22:42467013 NAGA 0.4 6.59 0.34 1.67e-10 Cognitive function; LUSC cis rs548181 0.577 rs569766 chr11:125532369 G/A cg03464685 chr11:125439445 EI24 1.15 13.9 0.61 5.42e-35 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs9951602 0.512 rs3859325 chr18:76652175 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.16 0.58 3.72e-32 Obesity-related traits; LUSC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg21017887 chr14:105400489 NA 0.69 13.07 0.58 8.32e-32 Rheumatoid arthritis; LUSC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg16060761 chr17:80687452 NA -0.53 -8.09 -0.4 1.13e-14 Glycated hemoglobin levels; LUSC cis rs72781680 1.000 rs11553491 chr2:24225901 G/C cg08917208 chr2:24149416 ATAD2B 0.9 10.11 0.48 3.82e-21 Lymphocyte counts; LUSC cis rs614226 0.938 rs7972244 chr12:120994872 A/G cg27489772 chr12:121021490 NA 0.59 7.84 0.39 6.09e-14 Type 1 diabetes nephropathy; LUSC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg10802521 chr3:52805072 NEK4 -0.53 -8.53 -0.42 5.26e-16 Bipolar disorder; LUSC cis rs11971779 0.680 rs10273527 chr7:139036598 A/C cg23387468 chr7:139079360 LUC7L2 -0.39 -5.91 -0.31 8.43e-9 Diisocyanate-induced asthma; LUSC cis rs11971779 0.680 rs17691238 chr7:139052284 A/G cg07862535 chr7:139043722 LUC7L2 -0.53 -6.71 -0.34 8.5e-11 Diisocyanate-induced asthma; LUSC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 8.26 0.41 3.48e-15 Age-related macular degeneration (geographic atrophy); LUSC trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg15704280 chr7:45808275 SEPT13 -0.63 -7.59 -0.38 3.18e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs853679 0.766 rs9368561 chr6:28168343 C/T cg06606381 chr12:133084897 FBRSL1 -0.62 -6.69 -0.34 9.53e-11 Depression; LUSC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg18230493 chr5:56204884 C5orf35 -0.66 -10.22 -0.49 1.66e-21 Coronary artery disease; LUSC cis rs950027 0.620 rs1153855 chr15:45660758 C/G cg04036182 chr15:45458818 NA 0.35 5.75 0.3 2.01e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs710216 0.917 rs900837 chr1:43412793 A/G cg03128534 chr1:43423976 SLC2A1 -0.45 -5.9 -0.31 8.85e-9 Red cell distribution width; LUSC trans rs2243480 0.901 rs13237344 chr7:66022256 T/A cg10756647 chr7:56101905 PSPH 0.89 9.05 0.44 1.19e-17 Diabetic kidney disease; LUSC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11890956 chr21:40555474 PSMG1 0.79 13.37 0.59 5.74e-33 Cognitive function; LUSC cis rs17270561 0.609 rs9358873 chr6:25731783 C/T cg16482183 chr6:26056742 HIST1H1C 0.66 9.22 0.45 3.37e-18 Iron status biomarkers; LUSC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg08704250 chr15:31115839 NA 0.6 9.29 0.45 2.1e-18 Huntington's disease progression; LUSC cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.96 0.7 5.97e-51 Chronic sinus infection; LUSC cis rs10788264 0.504 rs7898942 chr10:124024608 G/T cg09507567 chr10:124027408 NA -0.53 -9.23 -0.45 3.22e-18 Total body bone mineral density; LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg22166914 chr1:53195759 ZYG11B -0.62 -10.21 -0.49 1.73e-21 Monocyte count; LUSC cis rs6459804 0.935 rs72505543 chr7:157508867 G/A cg05731713 chr7:157510257 PTPRN2 0.49 9.54 0.46 3e-19 Bipolar disorder and schizophrenia; LUSC cis rs2708977 0.966 rs2708978 chr2:97202243 A/C cg01950434 chr2:97203154 ARID5A -0.57 -8.55 -0.42 4.5e-16 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs6582630 0.622 rs11831595 chr12:38511489 C/A cg26384229 chr12:38710491 ALG10B -0.55 -8.3 -0.41 2.58e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg18099408 chr3:52552593 STAB1 0.36 5.93 0.31 7.72e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs977987 0.843 rs17696749 chr16:75403062 C/G cg04384234 chr16:75411784 CFDP1 -0.45 -7.56 -0.38 3.85e-13 Dupuytren's disease; LUSC cis rs1577917 0.958 rs2100109 chr6:86544926 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.93 -0.44 2.81e-17 Response to antipsychotic treatment; LUSC cis rs864537 0.646 rs1723018 chr1:167433420 A/G cg22356347 chr1:167427500 CD247 -0.32 -7.86 -0.39 5.42e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs2273669 0.667 rs12197912 chr6:109338147 C/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 8.89e-9 Prostate cancer; LUSC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.49 0.59 2.14e-33 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg00071950 chr4:10020882 SLC2A9 0.62 10.15 0.49 2.72e-21 Bone mineral density; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.43 0.53 9.29e-26 Prudent dietary pattern; LUSC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg02175503 chr12:58329896 NA 0.41 5.85 0.3 1.17e-8 Multiple sclerosis; LUSC cis rs11098499 0.954 rs10518331 chr4:120323595 C/T cg24375607 chr4:120327624 NA 0.78 11.54 0.53 3.63e-26 Corneal astigmatism; LUSC cis rs7647973 1.000 rs11130190 chr3:49402137 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.46 6.99 0.36 1.53e-11 Menarche (age at onset); LUSC cis rs637571 0.565 rs570387 chr11:65637076 T/C cg26695010 chr11:65641043 EFEMP2 0.58 8.64 0.43 2.41e-16 Eosinophil percentage of white cells; LUSC cis rs7712401 0.601 rs425573 chr5:122326008 G/C cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs4919694 0.611 rs7091462 chr10:104948615 C/T cg04362960 chr10:104952993 NT5C2 0.91 11.75 0.54 6.36e-27 Arsenic metabolism; LUSC cis rs7903847 0.667 rs3818787 chr10:99145179 T/C cg20016023 chr10:99160130 RRP12 -0.32 -7.97 -0.4 2.49e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg03684893 chr10:554711 DIP2C -0.39 -7.03 -0.36 1.2e-11 Psychosis in Alzheimer's disease; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg10862848 chr6:42927986 GNMT -0.3 -7.28 -0.37 2.36e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.68 0.3 2.87e-8 Self-reported allergy; LUSC trans rs6502050 0.764 rs35416122 chr17:80119006 A/G cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs6500602 0.787 rs7204624 chr16:4459834 A/G cg08645402 chr16:4508243 NA 0.49 7.33 0.37 1.71e-12 Schizophrenia; LUSC cis rs6845621 0.745 rs6814138 chr4:18854323 A/G cg12196642 chr4:18937545 NA -0.31 -5.78 -0.3 1.72e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7084921 0.608 rs11598979 chr10:101833720 C/T cg02250046 chr10:101825185 CPN1 -0.33 -6.06 -0.31 3.69e-9 Bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25041148 chr19:58838420 ZSCAN22 -0.41 -6.14 -0.32 2.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg17372223 chr3:52568218 NT5DC2 0.38 6.04 0.31 4.16e-9 Electroencephalogram traits; LUSC cis rs68170813 0.599 rs6466162 chr7:106902625 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.96 -0.48 1.2e-20 Coronary artery disease; LUSC cis rs6489785 0.562 rs494632 chr12:121189116 C/T cg02419362 chr12:121203948 SPPL3 0.46 8.58 0.42 3.65e-16 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1788820 0.917 rs1788826 chr18:21154024 G/A cg14672496 chr18:21087552 C18orf8 0.43 7.09 0.36 8.14e-12 Body mass index; LUSC cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.16 -0.41 6.97e-15 Axial length; LUSC cis rs73198271 0.740 rs28521727 chr8:8647217 T/C cg01851573 chr8:8652454 MFHAS1 0.53 8.45 0.42 8.97e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2075371 0.501 rs1646654 chr7:134027547 G/C cg20476274 chr7:133979776 SLC35B4 0.73 12.21 0.56 1.36e-28 Mean platelet volume; LUSC cis rs11098499 0.909 rs28555550 chr4:120211040 C/G cg24375607 chr4:120327624 NA 0.73 10.64 0.5 5.66e-23 Corneal astigmatism; LUSC cis rs1044826 0.642 rs295470 chr3:139213903 A/G cg15131784 chr3:139108705 COPB2 0.41 6.67 0.34 1.08e-10 Obesity-related traits; LUSC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg22834771 chr12:69754056 YEATS4 -0.48 -7.26 -0.37 2.67e-12 Blood protein levels; LUSC cis rs12681288 0.676 rs1562921 chr8:1021986 G/T cg15309053 chr8:964076 NA 0.33 6.45 0.33 3.84e-10 Schizophrenia; LUSC cis rs936229 0.954 rs936230 chr15:75145098 C/T cg14664628 chr15:75095509 CSK 0.86 13.32 0.59 9.34e-33 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7267979 0.903 rs6115109 chr20:25239667 G/A cg08601574 chr20:25228251 PYGB 0.47 7.3 0.37 2.12e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7267979 0.528 rs6076366 chr20:25564626 G/T cg03522245 chr20:25566470 NINL -0.4 -6.1 -0.32 2.96e-9 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9747201 0.889 rs4789784 chr17:80179213 G/A cg07393940 chr7:158741817 NA 0.53 8.26 0.41 3.36e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg03146154 chr1:46216737 IPP 0.51 7.65 0.39 2.18e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2197308 0.765 rs68029712 chr12:37906585 T/G cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs6693567 0.545 rs7411534 chr1:150447269 C/T cg15654264 chr1:150340011 RPRD2 0.44 7.16 0.36 5.06e-12 Migraine; LUSC cis rs6961069 0.585 rs2691200 chr7:80240188 C/T cg04458919 chr7:80252533 CD36 -0.41 -7.37 -0.37 1.32e-12 Platelet count; LUSC cis rs3106136 0.967 rs61004493 chr4:95163317 T/C cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.08 -0.32 3.26e-9 Capecitabine sensitivity; LUSC cis rs6696846 0.765 rs11240360 chr1:205083865 T/C cg21643547 chr1:205240462 TMCC2 -0.41 -7.53 -0.38 4.7e-13 Red blood cell count; LUSC cis rs16976116 0.901 rs1061823 chr15:55496043 T/A cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.9e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg04518342 chr5:131593106 PDLIM4 0.5 8.88 0.44 4.09e-17 Acylcarnitine levels; LUSC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.51 7.88 0.4 4.61e-14 Eosinophil percentage of white cells; LUSC cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.0 0.44 1.77e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs3105593 0.933 rs4775894 chr15:50903600 C/T cg08437265 chr15:50716283 USP8 0.4 5.96 0.31 6.54e-9 QT interval; LUSC cis rs1570884 0.516 rs9535268 chr13:50175478 C/A cg03651054 chr13:50194643 NA 0.36 6.23 0.32 1.38e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg07661805 chr8:143867942 LY6D 0.27 6.17 0.32 2.03e-9 Urinary tract infection frequency; LUSC cis rs11098499 0.863 rs13149407 chr4:120437825 A/G cg09307838 chr4:120376055 NA 0.73 10.33 0.49 6.88e-22 Corneal astigmatism; LUSC cis rs478304 0.651 rs11600918 chr11:65511965 A/G cg27068330 chr11:65405492 SIPA1 -0.76 -11.03 -0.52 2.56e-24 Acne (severe); LUSC cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg03647239 chr10:116582469 FAM160B1 0.47 7.63 0.39 2.44e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7020830 0.894 rs13300951 chr9:37146627 A/G cg14294708 chr9:37120828 ZCCHC7 1.13 26.15 0.82 8.17e-83 Schizophrenia; LUSC cis rs4595586 0.679 rs35743713 chr12:39318539 C/G cg13010199 chr12:38710504 ALG10B 0.42 6.02 0.31 4.48e-9 Morning vs. evening chronotype; LUSC trans rs853679 0.769 rs7752608 chr6:28301195 A/G cg06606381 chr12:133084897 FBRSL1 -0.79 -7.4 -0.38 1.08e-12 Depression; LUSC trans rs17685 0.712 rs10235738 chr7:75773460 G/A cg19862616 chr7:65841803 NCRNA00174 1.12 18.97 0.72 5.86e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7633770 0.805 rs12330414 chr3:46662428 T/C cg11219411 chr3:46661640 NA 0.49 10.32 0.49 7.64e-22 Coronary artery disease; LUSC cis rs6977660 0.507 rs4719580 chr7:19784847 G/T cg05791153 chr7:19748676 TWISTNB 0.67 6.98 0.36 1.63e-11 Thyroid stimulating hormone; LUSC cis rs9814567 0.964 rs9841180 chr3:134191880 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.4 -0.56 2.57e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 11.22 0.52 5.31e-25 Alzheimer's disease; LUSC cis rs2845885 1.000 rs2845885 chr11:63869062 A/G cg24431193 chr11:63883947 FLRT1;MACROD1 0.67 6.11 0.32 2.73e-9 Body mass index; LUSC cis rs7923452 0.688 rs117895480 chr10:30788921 A/G cg25182066 chr10:30743637 MAP3K8 0.55 6.02 0.31 4.53e-9 Itch intensity from mosquito bite; LUSC cis rs4727027 0.522 rs6956736 chr7:148893472 G/C cg23158103 chr7:148848205 ZNF398 -0.4 -5.77 -0.3 1.85e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs861020 1.000 rs680923 chr1:209986672 T/C cg05527609 chr1:210001259 C1orf107 0.93 12.05 0.55 5.19e-28 Orofacial clefts; LUSC cis rs11625487 0.957 rs7156032 chr14:77951364 G/A cg20045696 chr14:77926864 AHSA1 -0.55 -7.38 -0.37 1.28e-12 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs4072705 0.615 rs4838189 chr9:127248926 C/A cg13476313 chr9:127244764 NR5A1 0.33 6.25 0.32 1.22e-9 Menarche (age at onset); LUSC cis rs4499344 0.769 rs114289041 chr19:33083746 A/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.59 -7.7 -0.39 1.52e-13 Mean platelet volume; LUSC cis rs1823874 0.962 rs12906206 chr15:100359126 A/T cg16400843 chr15:100339927 C15orf51 0.42 8.25 0.41 3.77e-15 IgG glycosylation; LUSC cis rs9303401 0.632 rs7222087 chr17:57221619 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.5 7.75 0.39 1.13e-13 Cognitive test performance; LUSC cis rs2290416 0.892 rs76108894 chr8:144673533 G/A cg26536354 chr8:144654954 C8orf73 0.65 7.23 0.37 3.27e-12 Attention deficit hyperactivity disorder; LUSC cis rs1577917 1.000 rs7747824 chr6:86647106 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs10752881 0.967 rs8179284 chr1:182974707 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg07424592 chr7:64974309 NA 1.05 6.47 0.33 3.41e-10 Diabetic kidney disease; LUSC cis rs6690583 0.623 rs61770879 chr1:85504938 A/C cg11262906 chr1:85462892 MCOLN2 0.63 6.0 0.31 5.08e-9 Serum sulfate level; LUSC cis rs4946717 0.740 rs6941301 chr6:106472457 T/C cg02270332 chr6:106475062 NA 0.46 9.44 0.46 6.72e-19 Inflammatory bowel disease; LUSC cis rs7903847 0.642 rs2297668 chr10:99160046 C/T cg20016023 chr10:99160130 RRP12 -0.3 -7.57 -0.38 3.68e-13 Granulocyte percentage of myeloid white cells; LUSC trans rs2243480 0.908 rs1532573 chr7:65798802 A/G cg10756647 chr7:56101905 PSPH -0.86 -8.52 -0.42 5.52e-16 Diabetic kidney disease; LUSC cis rs116139393 0.561 rs62439737 chr7:6779810 A/G cg09896999 chr7:6746977 ZNF12 -0.5 -7.04 -0.36 1.12e-11 Alzheimer's disease (APOE e4 interaction); LUSC cis rs877282 0.898 rs12357016 chr10:765675 C/T cg17470449 chr10:769945 NA 0.53 7.09 0.36 8.21e-12 Uric acid levels; LUSC cis rs7712401 0.601 rs246285 chr5:122244968 C/G cg19077854 chr5:122220652 SNX24 -0.4 -9.09 -0.45 8.72e-18 Mean platelet volume; LUSC cis rs3125734 0.633 rs4979782 chr10:63998527 C/T cg09941381 chr10:64027924 RTKN2 -0.38 -7.05 -0.36 1.02e-11 Rheumatoid arthritis; LUSC cis rs7843479 0.544 rs11135735 chr8:21791557 C/T cg17168535 chr8:21777572 XPO7 0.81 14.62 0.62 9.18e-38 Mean corpuscular volume; LUSC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 14.42 0.62 5.73e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25263898 chr1:36774223 C1orf113 0.49 5.96 0.31 6.33e-9 Bipolar disorder and schizophrenia; LUSC cis rs1451375 0.617 rs880029 chr7:50569927 G/C cg18232548 chr7:50535776 DDC -0.53 -7.39 -0.37 1.22e-12 Malaria; LUSC cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg04455712 chr21:45112962 RRP1B 0.49 9.12 0.45 7.25e-18 Coronary artery disease; LUSC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg14019146 chr3:50243930 SLC38A3 0.31 6.95 0.36 1.93e-11 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs2424713 chr20:25418482 C/T cg08601574 chr20:25228251 PYGB 0.43 6.62 0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.75 0.3 2e-8 Tonsillectomy; LUSC cis rs1784581 0.588 rs6455790 chr6:162418447 C/T cg17173639 chr6:162384350 PARK2 -0.55 -9.6 -0.46 1.99e-19 Itch intensity from mosquito bite; LUSC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg18876405 chr7:65276391 NA -0.56 -8.88 -0.44 4.05e-17 Aortic root size; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.85 0.44 5.31e-17 Prudent dietary pattern; LUSC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg11764359 chr7:65958608 NA 0.68 9.91 0.48 1.8899999999999998e-20 Aortic root size; LUSC cis rs6456156 0.586 rs1407315 chr6:167468659 A/G cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs9790314 0.967 rs1382427 chr3:161032576 T/C cg03342759 chr3:160939853 NMD3 -0.49 -8.16 -0.41 6.68e-15 Morning vs. evening chronotype; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01516881 chr6:292596 DUSP22 0.71 11.41 0.53 1.07e-25 Menopause (age at onset); LUSC cis rs9653442 0.545 rs13032454 chr2:100756009 T/C cg22139774 chr2:100720529 AFF3 -0.43 -7.25 -0.37 2.95e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6500602 0.727 rs11076837 chr16:4569440 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.54 7.28 0.37 2.39e-12 Schizophrenia; LUSC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg02951883 chr7:2050386 MAD1L1 -0.56 -10.05 -0.48 6.26e-21 Bipolar disorder and schizophrenia; LUSC cis rs9549260 0.755 rs2721067 chr13:41156708 C/T cg21288729 chr13:41239152 FOXO1 0.61 9.43 0.46 7.1e-19 Red blood cell count; LUSC cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg23093090 chr10:104574429 C10orf26 -0.46 -8.4 -0.42 1.28e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs983392 0.709 rs2015475 chr11:59998963 A/C cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 8.13 0.41 8.71e-15 Height; LUSC trans rs7829975 0.606 rs10112585 chr8:8795030 A/T cg27411982 chr8:10470053 RP1L1 -0.37 -6.17 -0.32 1.92e-9 Mood instability; LUSC cis rs7432375 0.580 rs4678442 chr3:136532971 A/G cg15507776 chr3:136538369 TMEM22 0.44 7.37 0.37 1.34e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg06008330 chr7:65541103 ASL -0.4 -6.17 -0.32 1.94e-9 Aortic root size; LUSC cis rs7043114 0.563 rs7848391 chr9:95337520 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.32 -5.8 -0.3 1.55e-8 Height; LUSC cis rs9283706 0.689 rs11956654 chr5:66318196 A/G cg11590213 chr5:66331682 MAST4 0.48 6.89 0.35 2.78e-11 Coronary artery disease; LUSC cis rs7177699 0.557 rs4380028 chr15:79111093 C/T cg15571903 chr15:79123663 NA -0.33 -6.13 -0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4680 0.737 rs2239393 chr22:19950428 A/G cg23601416 chr22:19950040 COMT -0.44 -9.17 -0.45 5.16e-18 Blood metabolite levels; LUSC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg25258033 chr6:167368657 RNASET2 0.48 7.8 0.39 7.93e-14 Crohn's disease; LUSC cis rs7809950 0.637 rs3801964 chr7:106836242 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.91 -0.44 3.29e-17 Coronary artery disease; LUSC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg04287289 chr16:89883240 FANCA 0.77 12.96 0.58 2.14e-31 Vitiligo; LUSC cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.93 -0.31 7.69e-9 IgG glycosylation; LUSC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg10560079 chr2:191398806 TMEM194B -0.45 -7.43 -0.38 8.91e-13 Pulse pressure; LUSC cis rs9660992 0.662 rs12092492 chr1:205251880 T/C cg21643547 chr1:205240462 TMCC2 -0.49 -9.37 -0.46 1.08e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs757110 0.705 rs10832778 chr11:17394073 C/G cg15432903 chr11:17409602 KCNJ11 0.61 10.76 0.51 2.15e-23 Type 2 diabetes; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg24675658 chr1:53192096 ZYG11B 0.58 9.11 0.45 7.6e-18 Monocyte count; LUSC cis rs7119 0.931 rs7176875 chr15:77832675 A/G cg27398640 chr15:77910606 LINGO1 0.32 7.3 0.37 2.06e-12 Type 2 diabetes; LUSC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg00049323 chr5:472564 LOC25845 -0.42 -6.54 -0.34 2.34e-10 Cystic fibrosis severity; LUSC trans rs2786098 0.656 rs10494758 chr1:197528149 A/G cg16005942 chr6:160526640 IGF2R 0.51 6.03 0.31 4.34e-9 Asthma; LUSC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg13628971 chr7:2884303 GNA12 0.38 5.85 0.31 1.15e-8 Height; LUSC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg06850241 chr22:41845214 NA 0.31 5.73 0.3 2.23e-8 Vitiligo; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg23102388 chr7:1867652 MAD1L1 -0.3 -5.68 -0.3 2.97e-8 Bipolar disorder and schizophrenia; LUSC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg04486885 chr5:176823424 SLC34A1 -0.38 -5.86 -0.31 1.14e-8 Hemoglobin concentration;Hematocrit; LUSC trans rs117147772 0.579 rs9916504 chr17:52050771 A/G cg14684068 chr11:63894400 MACROD1 -0.53 -5.99 -0.31 5.51e-9 Photic sneeze reflex; LUSC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg03929089 chr4:120376271 NA -0.76 -10.29 -0.49 9.54e-22 Coronary artery disease; LUSC cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.05 0.48 5.98e-21 Bladder cancer; LUSC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.06 -0.31 3.68e-9 Total body bone mineral density; LUSC cis rs6565180 0.525 rs1132812 chr16:30198151 A/G cg17640201 chr16:30407289 ZNF48 0.63 10.23 0.49 1.46e-21 Tonsillectomy; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg11494091 chr17:61959527 GH2 0.66 13.94 0.61 3.9e-35 Prudent dietary pattern; LUSC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg21573476 chr21:45109991 RRP1B -0.4 -6.26 -0.32 1.2e-9 Mean corpuscular volume; LUSC cis rs7607369 0.536 rs7600248 chr2:219665963 C/T cg02176678 chr2:219576539 TTLL4 -0.51 -9.02 -0.44 1.52e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.0 -0.48 8.83e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11031096 0.868 rs2923953 chr11:4045757 G/A cg18678763 chr11:4115507 RRM1 0.39 5.69 0.3 2.82e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10193935 0.901 rs2374405 chr2:42479874 A/C cg27598129 chr2:42591480 NA -0.61 -8.24 -0.41 3.89e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7615316 0.789 rs9846960 chr3:142308070 G/A cg16271453 chr3:142027066 XRN1 -0.36 -6.03 -0.31 4.41e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg04352962 chr1:209979756 IRF6 -0.43 -6.52 -0.34 2.52e-10 Monobrow; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11327054 chr11:6502632 FXC1;ARFIP2 -0.41 -5.96 -0.31 6.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs473651 0.935 rs508483 chr2:239339709 T/C cg21699342 chr2:239360505 ASB1 0.56 10.54 0.5 1.28e-22 Multiple system atrophy; LUSC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg24881330 chr22:46731750 TRMU 0.84 7.39 0.37 1.22e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg23029597 chr12:123009494 RSRC2 -0.7 -9.37 -0.46 1.11e-18 Body mass index; LUSC trans rs1325195 0.920 rs915337 chr1:179223751 A/G cg11624085 chr17:8464688 MYH10 -0.41 -6.82 -0.35 4.34e-11 IgE grass sensitization; LUSC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.24 0.41 3.84e-15 Melanoma; LUSC cis rs12681288 0.550 rs4637864 chr8:959761 C/T cg04851639 chr8:1020857 NA -0.35 -7.01 -0.36 1.29e-11 Schizophrenia; LUSC cis rs9814567 0.727 rs4543053 chr3:134351724 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.79 -12.94 -0.58 2.45e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10779751 0.575 rs2791655 chr1:11128654 A/G cg08854313 chr1:11322531 MTOR -0.69 -10.45 -0.5 2.72e-22 Body mass index; LUSC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg24531977 chr5:56204891 C5orf35 0.72 10.9 0.51 7.29e-24 Type 2 diabetes; LUSC cis rs12286929 0.668 rs17304149 chr11:115049180 C/T cg04055981 chr11:115044050 NA 0.41 7.32 0.37 1.9e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg16049864 chr8:95962084 TP53INP1 -0.72 -14.21 -0.61 3.72e-36 Type 2 diabetes; LUSC trans rs7189501 1.000 rs9646296 chr16:6170195 C/T cg04663720 chr19:8454898 RAB11B 0.37 5.95 0.31 6.83e-9 Body mass index; LUSC cis rs4474465 0.850 rs4285892 chr11:78243134 C/A cg27205649 chr11:78285834 NARS2 0.51 6.26 0.32 1.16e-9 Alzheimer's disease (survival time); LUSC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg25019033 chr10:957182 NA -0.53 -6.1 -0.32 2.91e-9 Eosinophil percentage of granulocytes; LUSC cis rs7954584 0.635 rs3847694 chr12:122325820 A/G cg13699009 chr12:122356056 WDR66 0.47 7.51 0.38 5.37e-13 Mean corpuscular volume; LUSC cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg04450456 chr4:17643702 FAM184B -0.39 -6.39 -0.33 5.7e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg06134567 chr22:46658398 PKDREJ -0.53 -5.69 -0.3 2.73e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs4654899 0.802 rs17449966 chr1:21203996 A/G cg01072550 chr1:21505969 NA -0.52 -7.72 -0.39 1.37e-13 Superior frontal gyrus grey matter volume; LUSC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.71 -8.58 -0.42 3.64e-16 Glomerular filtration rate in chronic kidney disease; LUSC trans rs12200782 1.000 rs10456330 chr6:26436692 C/T cg11837749 chr1:55047332 ACOT11 0.58 6.23 0.32 1.41e-9 Small cell lung carcinoma; LUSC cis rs9394931 1.000 rs9394931 chr6:42873245 C/T cg21280719 chr6:42927975 GNMT 0.26 6.18 0.32 1.91e-9 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); LUSC cis rs8016982 0.633 rs8015423 chr14:81719357 C/T cg01989461 chr14:81687754 GTF2A1 0.7 12.4 0.56 2.65e-29 Schizophrenia; LUSC cis rs1858037 0.867 rs876933 chr2:65609437 C/T cg08085232 chr2:65598271 SPRED2 -0.43 -6.33 -0.33 7.79e-10 Rheumatoid arthritis; LUSC cis rs7843479 1.000 rs17615788 chr8:21814739 C/T cg17168535 chr8:21777572 XPO7 0.67 10.34 0.49 6.42e-22 Mean corpuscular volume; LUSC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg20135002 chr11:47629003 NA 0.5 7.81 0.39 7.45e-14 Subjective well-being; LUSC cis rs4595586 0.546 rs10876163 chr12:39244915 G/A cg13010199 chr12:38710504 ALG10B 0.63 9.21 0.45 3.83e-18 Morning vs. evening chronotype; LUSC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18099408 chr3:52552593 STAB1 -0.41 -7.2 -0.37 3.9e-12 Bipolar disorder; LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg18404041 chr3:52824283 ITIH1 -0.55 -10.47 -0.5 2.33e-22 Bipolar disorder; LUSC cis rs17539620 0.624 rs871068 chr6:154837514 C/A cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg12560992 chr17:57184187 TRIM37 0.84 15.33 0.64 1.53e-40 Intelligence (multi-trait analysis); LUSC cis rs10744422 0.800 rs839363 chr12:123276924 C/T cg25930673 chr12:123319894 HIP1R -0.6 -5.99 -0.31 5.57e-9 Schizophrenia; LUSC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.54 0.5 1.27e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg23711669 chr6:146136114 FBXO30 0.72 11.15 0.52 9.19e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg10523679 chr1:76189770 ACADM 0.89 14.2 0.61 4.07e-36 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs7613875 0.600 rs2856237 chr3:50158774 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.51 -8.01 -0.4 1.95e-14 Body mass index; LUSC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.1 0.41 1.03e-14 Melanoma; LUSC trans rs2898290 0.578 rs34163377 chr8:11450213 C/G cg15556689 chr8:8085844 FLJ10661 0.59 8.85 0.44 5.14e-17 Systolic blood pressure; LUSC cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg27446573 chr6:127587934 RNF146 0.92 15.28 0.64 2.55e-40 Breast cancer; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.45 -6.95 -0.36 1.94e-11 Prudent dietary pattern; LUSC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg16325326 chr1:53192061 ZYG11B 0.88 15.41 0.64 7.38e-41 Monocyte count; LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.37 -0.37 1.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC cis rs78707713 0.560 rs35060419 chr10:71229539 A/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.58 -0.46 2.31e-19 Venous thromboembolism; LUSC trans rs9944715 0.911 rs8085138 chr18:43768751 G/A cg01718231 chr17:29326311 RNF135 -0.51 -7.31 -0.37 2.04e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg06238570 chr21:40685208 BRWD1 -0.56 -9.03 -0.44 1.37e-17 Menarche (age at onset); LUSC cis rs981844 0.775 rs62323975 chr4:154737617 A/G cg14289246 chr4:154710475 SFRP2 0.47 6.34 0.33 7.27e-10 Response to statins (LDL cholesterol change); LUSC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg04398451 chr17:18023971 MYO15A -0.54 -8.8 -0.43 7.66e-17 Total body bone mineral density; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.42 0.38 9.97e-13 Intelligence (multi-trait analysis); LUSC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg04248312 chr19:17393744 ANKLE1 -1.0 -16.83 -0.68 1.77e-46 Systemic lupus erythematosus; LUSC cis rs7909074 0.798 rs10900126 chr10:45386322 G/T cg05187965 chr10:45406764 TMEM72 -0.37 -8.45 -0.42 9.04e-16 Mean corpuscular volume; LUSC cis rs13315871 1.000 rs13078787 chr3:58430487 C/T cg12435725 chr3:58293450 RPP14 -0.7 -6.93 -0.35 2.21e-11 Cholesterol, total; LUSC cis rs1790761 0.607 rs656652 chr11:67343957 C/T cg08355456 chr11:67383691 NA 0.37 6.92 0.35 2.31e-11 Mean corpuscular volume; LUSC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg25174290 chr11:3078921 CARS 0.6 9.38 0.46 1.07e-18 Longevity; LUSC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg18225595 chr11:63971243 STIP1 0.53 9.06 0.44 1.11e-17 Platelet count; LUSC cis rs9486715 0.867 rs11152924 chr6:96877383 A/G cg06623918 chr6:96969491 KIAA0776 0.93 17.58 0.69 1.94e-49 Headache; LUSC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.94 0.36 2.05e-11 Cystic fibrosis severity; LUSC cis rs4343996 0.869 rs10256740 chr7:3481667 G/A cg21248987 chr7:3385318 SDK1 0.36 5.96 0.31 6.51e-9 Motion sickness; LUSC cis rs11997175 0.625 rs17698353 chr8:33592241 A/G ch.8.33884649F chr8:33765107 NA 0.42 6.66 0.34 1.15e-10 Body mass index; LUSC cis rs2235642 0.717 rs2236269 chr16:1652614 T/A cg09025071 chr16:1593152 IFT140;TMEM204 0.31 7.01 0.36 1.31e-11 Coronary artery disease; LUSC cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg03060546 chr3:49711283 APEH 0.67 7.45 0.38 8.01e-13 Menarche (age at onset); LUSC cis rs4423214 0.840 rs1792227 chr11:71177412 A/G cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC trans rs4948088 1.000 rs2876901 chr7:51018071 T/C cg26816907 chr1:197890812 LHX9 0.56 6.22 0.32 1.47e-9 Type 1 diabetes; LUSC cis rs9463078 0.605 rs1578676 chr6:44906861 G/A cg25276700 chr6:44698697 NA 0.3 6.18 0.32 1.87e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg12365402 chr11:9010492 NRIP3 0.36 6.29 0.33 1.01e-9 Hemoglobin concentration; LUSC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg03517284 chr6:25882590 NA 0.65 11.4 0.53 1.23e-25 Blood metabolite levels; LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.87 0.31 1.05e-8 Menopause (age at onset); LUSC cis rs2282300 0.739 rs1717775 chr11:30350254 T/G cg25418670 chr11:30344373 C11orf46 -0.64 -9.27 -0.45 2.28e-18 Morning vs. evening chronotype; LUSC cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg21643547 chr1:205240462 TMCC2 -0.53 -10.11 -0.48 3.74e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs68170813 0.523 rs11766131 chr7:107071138 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.44 -5.68 -0.3 2.95e-8 Coronary artery disease; LUSC cis rs68170813 0.652 rs11532774 chr7:107201579 T/C cg02696742 chr7:106810147 HBP1 -0.64 -8.6 -0.43 3.11e-16 Coronary artery disease; LUSC cis rs6500602 0.964 rs13335685 chr16:4469284 T/C cg08645402 chr16:4508243 NA 0.53 8.96 0.44 2.31e-17 Schizophrenia; LUSC cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.21 -0.45 3.77e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9303401 0.614 rs34920953 chr17:56589406 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.1 0.58 6.58e-32 Cognitive test performance; LUSC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -7.43 -0.38 9.27e-13 Platelet count; LUSC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg23711669 chr6:146136114 FBXO30 -0.75 -11.86 -0.54 2.61e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.55 0.38 4.06e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg07677032 chr17:61819896 STRADA 0.54 8.53 0.42 5.07e-16 Prudent dietary pattern; LUSC cis rs1577917 0.740 rs9344542 chr6:86393905 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 9.3 0.45 1.89e-18 Response to antipsychotic treatment; LUSC cis rs8072100 0.764 rs4794371 chr17:45627693 G/C cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.72 0.3 2.32e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9837602 1.000 rs9832186 chr3:99728503 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.18 0.32 1.82e-9 Breast cancer; LUSC cis rs859767 0.704 rs7570717 chr2:135361035 C/T cg12500956 chr2:135428796 TMEM163 -0.28 -6.59 -0.34 1.72e-10 Neuroticism; LUSC cis rs2439831 0.764 rs2447193 chr15:43929733 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg04034577 chr2:241836375 C2orf54 -0.49 -8.92 -0.44 3.03e-17 Urinary metabolites; LUSC cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg08085267 chr17:45401833 C17orf57 0.54 8.85 0.44 5.16e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg14711859 chr11:8959438 ASCL3 0.38 5.86 0.31 1.13e-8 Hematocrit; LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg18404041 chr3:52824283 ITIH1 -0.61 -11.88 -0.54 2.22e-27 Bipolar disorder; LUSC cis rs7584330 0.518 rs11888077 chr2:238424763 G/A cg14458575 chr2:238380390 NA 0.62 7.38 0.37 1.23e-12 Prostate cancer; LUSC cis rs1018836 0.608 rs2142147 chr8:91468200 A/G cg16814680 chr8:91681699 NA -0.54 -7.84 -0.39 6e-14 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9807989 0.801 rs10176664 chr2:102976172 G/A cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs3820068 0.608 rs12734937 chr1:16047726 T/C cg24675056 chr1:15929824 NA 0.42 6.83 0.35 3.94e-11 Systolic blood pressure; LUSC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg20243544 chr17:37824526 PNMT 0.48 5.86 0.31 1.08e-8 Glomerular filtration rate (creatinine); LUSC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg00316803 chr15:76480434 C15orf27 0.4 7.09 0.36 7.81e-12 Blood metabolite levels; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.3 0.45 1.9e-18 Prudent dietary pattern; LUSC cis rs6982240 0.514 rs28588820 chr8:142285342 C/T cg00131261 chr8:142287264 NA -0.35 -5.7 -0.3 2.62e-8 Tonsillectomy; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg04025307 chr7:1156635 C7orf50 0.4 6.2 0.32 1.69e-9 Longevity;Endometriosis; LUSC cis rs10791323 0.576 rs4937840 chr11:133734322 C/G cg00579200 chr11:133705235 NA -0.42 -6.23 -0.32 1.38e-9 Childhood ear infection; LUSC cis rs7100689 0.784 rs1870142 chr10:82182296 G/A cg00277334 chr10:82204260 NA -0.56 -7.47 -0.38 7.21e-13 Post bronchodilator FEV1; LUSC cis rs250677 0.522 rs10040798 chr5:148367324 A/G cg18129178 chr5:148520854 ABLIM3 0.54 7.74 0.39 1.19e-13 Breast cancer; LUSC cis rs75920871 0.557 rs11216275 chr11:116975704 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.16 -0.32 2.04e-9 Subjective well-being; LUSC cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -9.01 -0.44 1.66e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6930083 0.605 rs3829964 chr6:36644498 T/C cg24425727 chr6:36645648 CDKN1A -0.29 -6.2 -0.32 1.66e-9 Coronary artery disease; LUSC cis rs9309473 0.950 rs73947808 chr2:73721250 A/C cg20560298 chr2:73613845 ALMS1 -0.52 -7.56 -0.38 4e-13 Metabolite levels; LUSC trans rs6480314 0.542 rs12572960 chr10:70030723 C/G cg04882175 chr6:131122610 NA -0.54 -6.18 -0.32 1.91e-9 Optic nerve measurement (disc area); LUSC cis rs2070488 0.775 rs1073505 chr3:38566722 T/C cg24069376 chr3:38537580 EXOG -0.38 -7.4 -0.38 1.09e-12 Electrocardiographic conduction measures; LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg01802117 chr1:53393560 SCP2 -0.4 -6.61 -0.34 1.5e-10 Monocyte count; LUSC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg07424592 chr7:64974309 NA -0.64 -5.71 -0.3 2.46e-8 Diabetic kidney disease; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg09033563 chr22:24373618 LOC391322 0.49 6.95 0.36 1.97e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4845570 0.850 rs4504897 chr1:151766851 T/A cg07092448 chr1:151763213 TDRKH 1.29 17.94 0.7 6.87e-51 Coronary artery disease; LUSC cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.98 0.72 5.41e-55 Chronic sinus infection; LUSC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg16447950 chr5:562315 NA -0.58 -7.3 -0.37 2.1e-12 Obesity-related traits; LUSC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg16405210 chr4:1374714 KIAA1530 -0.57 -8.84 -0.44 5.51e-17 Obesity-related traits; LUSC cis rs9462027 0.628 rs6457795 chr6:34819366 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.82 -0.3 1.35e-8 Systemic lupus erythematosus; LUSC cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 18.1 0.7 1.66e-51 Chronic sinus infection; LUSC cis rs2475553 0.520 rs62437129 chr6:158655757 T/G cg07165851 chr6:158734300 TULP4 0.48 6.85 0.35 3.53e-11 Lipoprotein (a) - cholesterol levels; LUSC cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg01028140 chr2:1542097 TPO -0.37 -5.98 -0.31 5.6e-9 IgG glycosylation; LUSC cis rs56399783 0.901 rs73049327 chr7:2795544 T/G cg14895029 chr7:2775587 GNA12 0.52 5.66 0.3 3.34e-8 Childhood ear infection; LUSC cis rs240764 0.782 rs239222 chr6:101112817 T/A cg09795085 chr6:101329169 ASCC3 0.4 5.85 0.3 1.18e-8 Neuroticism; LUSC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.22e-12 Extrinsic epigenetic age acceleration; LUSC cis rs4474465 0.915 rs12272791 chr11:78159426 G/A cg27205649 chr11:78285834 NARS2 -0.54 -6.25 -0.32 1.22e-9 Alzheimer's disease (survival time); LUSC cis rs8017423 0.967 rs8021881 chr14:90722276 T/C cg04374321 chr14:90722782 PSMC1 0.75 12.08 0.55 4e-28 Mortality in heart failure; LUSC cis rs2970818 0.831 rs2907495 chr12:4638164 T/C cg11146114 chr12:4671731 NA -0.57 -6.06 -0.31 3.63e-9 Phosphorus levels; LUSC cis rs868036 0.718 rs4776982 chr15:68114974 C/T cg08079166 chr15:68083412 MAP2K5 -0.42 -7.46 -0.38 7.46e-13 Restless legs syndrome; LUSC cis rs4704187 0.640 rs7707246 chr5:74354875 G/T cg03227963 chr5:74354835 NA 0.32 6.94 0.36 2.03e-11 Response to amphetamines; LUSC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg20203395 chr5:56204925 C5orf35 -0.56 -8.14 -0.41 7.65e-15 Initial pursuit acceleration; LUSC cis rs7772486 0.875 rs2207785 chr6:146332784 T/G cg05347473 chr6:146136440 FBXO30 0.52 8.87 0.44 4.42e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs6542838 0.641 rs6757098 chr2:99471399 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.51 -0.34 2.79e-10 Fear of minor pain; LUSC cis rs7106204 0.609 rs35037636 chr11:24299533 C/G ch.11.24196551F chr11:24239977 NA 0.69 5.68 0.3 2.86e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs1751857 0.826 rs2802512 chr13:40972166 T/C cg24642820 chr3:13462465 NUP210 0.62 5.97 0.31 6.2e-9 Body mass index (change over time) in chronic obstructive pulmonary disease; LUSC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.58 7.62 0.38 2.63e-13 Lung function (FEV1/FVC); LUSC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg25019033 chr10:957182 NA -0.52 -7.1 -0.36 7.75e-12 Eosinophil percentage of granulocytes; LUSC cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 5.68 0.3 2.92e-8 Schizophrenia; LUSC cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC cis rs10740039 0.883 rs7069814 chr10:62396759 C/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg03790207 chr6:42947109 PEX6 -0.45 -6.79 -0.35 5.08e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs11098499 0.954 rs10031665 chr4:120422852 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg06238570 chr21:40685208 BRWD1 -0.59 -9.22 -0.45 3.36e-18 Menarche (age at onset); LUSC cis rs75804782 0.641 rs55740938 chr2:239332647 G/A cg18131467 chr2:239335373 ASB1 -0.79 -6.72 -0.35 7.63e-11 Morning vs. evening chronotype;Chronotype; LUSC cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg26384229 chr12:38710491 ALG10B -0.81 -13.99 -0.61 2.61e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg18230493 chr5:56204884 C5orf35 -0.94 -13.77 -0.6 1.82e-34 Initial pursuit acceleration; LUSC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg00074818 chr8:8560427 CLDN23 0.59 9.9 0.48 1.99e-20 Obesity-related traits; LUSC cis rs9287719 0.901 rs6432109 chr2:10736821 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs73198271 0.595 rs55874147 chr8:8591954 T/C cg01851573 chr8:8652454 MFHAS1 0.46 5.77 0.3 1.83e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs8072100 0.840 rs9893901 chr17:45506682 T/G cg08085267 chr17:45401833 C17orf57 -0.54 -8.67 -0.43 1.95e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg07362569 chr17:61921086 SMARCD2 0.37 7.57 0.38 3.7e-13 Prudent dietary pattern; LUSC cis rs11677416 1.000 rs2071375 chr2:113535438 C/T cg27083787 chr2:113543245 IL1A 0.48 7.37 0.37 1.39e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs12681287 0.604 rs7017716 chr8:87429001 A/C cg00550725 chr8:87521180 FAM82B 0.42 5.68 0.3 2.89e-8 Caudate activity during reward; LUSC cis rs7786877 0.583 rs41303510 chr7:100226129 C/T cg20848291 chr7:100343083 ZAN -0.58 -7.02 -0.36 1.21e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6987853 0.787 rs2974309 chr8:42426961 G/A cg09913449 chr8:42400586 C8orf40 0.53 9.23 0.45 3.16e-18 Mean corpuscular hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26147372 chr3:49130904 QRICH1 0.43 5.96 0.31 6.35e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg08280861 chr8:58055591 NA 0.56 6.05 0.31 3.96e-9 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg00310523 chr12:86230176 RASSF9 -0.44 -8.28 -0.41 3.05e-15 Major depressive disorder; LUSC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg00310523 chr12:86230176 RASSF9 0.44 7.86 0.4 5.31e-14 Major depressive disorder; LUSC cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg16586182 chr3:47516702 SCAP -0.51 -7.16 -0.36 5.25e-12 Birth weight; LUSC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.59 -8.54 -0.42 4.8e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg12311346 chr5:56204834 C5orf35 0.64 9.86 0.47 2.64e-20 Coronary artery disease; LUSC cis rs2742234 0.955 rs1272142 chr10:43695484 G/T cg15436174 chr10:43711423 RASGEF1A -0.36 -6.66 -0.34 1.16e-10 Hirschsprung disease; LUSC trans rs2197308 0.703 rs10880251 chr12:37903297 G/A cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs2692947 0.832 rs4907212 chr2:96410048 T/A cg23100626 chr2:96804247 ASTL 0.26 6.38 0.33 6.08e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg22782873 chr19:19639568 YJEFN3 -0.47 -5.83 -0.3 1.34e-8 Bipolar disorder; LUSC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg10792982 chr14:105748885 BRF1 0.46 8.2 0.41 5.2e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.13 0.55 2.54e-28 Cognitive test performance; LUSC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC trans rs3127573 0.843 rs3127579 chr6:160674632 G/A cg17033287 chr1:3056542 PRDM16 0.41 6.08 0.32 3.27e-9 Creatinine levels; LUSC cis rs2279817 1.000 rs1339800 chr1:18020201 C/G cg21791023 chr1:18019539 ARHGEF10L -0.47 -6.67 -0.34 1.07e-10 Neuroticism; LUSC cis rs9911578 0.967 rs7214892 chr17:57065401 G/A cg05425664 chr17:57184151 TRIM37 -0.57 -8.39 -0.42 1.35e-15 Intelligence (multi-trait analysis); LUSC cis rs2777491 0.540 rs7164684 chr15:41705008 G/T cg18705301 chr15:41695430 NDUFAF1 -1.02 -21.6 -0.76 2.32e-65 Ulcerative colitis; LUSC trans rs35110281 0.667 rs4819291 chr21:45123139 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.53 0.5 1.4e-22 Mean corpuscular volume; LUSC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg23093090 chr10:104574429 C10orf26 -0.39 -7.5 -0.38 5.84e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9443189 0.570 rs276684 chr6:76427065 A/G cg01950844 chr6:76311363 SENP6 -0.71 -7.11 -0.36 7.15e-12 Prostate cancer; LUSC cis rs9361491 0.534 rs10943568 chr6:79404207 G/T cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.64 -0.3 3.54e-8 Intelligence (multi-trait analysis); LUSC cis rs6456156 0.774 rs2021999 chr6:167529766 G/C cg07741184 chr6:167504864 NA -0.36 -6.34 -0.33 7.42e-10 Primary biliary cholangitis; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg02178630 chr2:218678534 TNS1 0.45 5.96 0.31 6.35e-9 Neuroticism; LUSC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg02951883 chr7:2050386 MAD1L1 -0.46 -7.9 -0.4 4.17e-14 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC trans rs6601327 0.775 rs12156017 chr8:9406837 C/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.31 -0.33 8.79e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs2486288 0.656 rs7171312 chr15:45570225 C/G cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.42e-10 Glomerular filtration rate; LUSC cis rs11039100 0.850 rs34161300 chr11:5830740 G/C cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg04414720 chr1:150670196 GOLPH3L 0.49 7.78 0.39 9.11e-14 Melanoma; LUSC trans rs11098499 0.866 rs6824111 chr4:120285968 T/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12421382 0.614 rs11213104 chr11:109391297 G/T cg11473876 chr11:109292803 C11orf87 0.34 5.76 0.3 1.88e-8 Schizophrenia; LUSC trans rs3733585 0.699 rs4473653 chr4:9971058 A/G cg26043149 chr18:55253948 FECH -0.46 -7.11 -0.36 7.25e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg20701182 chr2:24300061 SF3B14 0.89 11.68 0.54 1.21e-26 Lymphocyte counts; LUSC cis rs9463078 0.547 rs2038555 chr6:44744033 A/G cg25276700 chr6:44698697 NA 0.3 6.33 0.33 7.67e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs59698941 0.765 rs66822519 chr5:132167742 C/T cg02081065 chr5:132209139 LEAP2 -0.62 -6.06 -0.31 3.66e-9 Apolipoprotein A-IV levels; LUSC cis rs11583043 1.000 rs2391573 chr1:101489698 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.25 0.32 1.22e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg26513180 chr16:89883248 FANCA 0.9 17.38 0.69 1.18e-48 Vitiligo; LUSC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg26116260 chr4:7069785 GRPEL1 1.14 17.95 0.7 6.69e-51 Monocyte percentage of white cells; LUSC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg00033643 chr7:134001901 SLC35B4 0.47 7.3 0.37 2.15e-12 Mean platelet volume; LUSC cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.81 0.43 6.77e-17 Axial length; LUSC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg03351412 chr1:154909251 PMVK 0.39 5.8 0.3 1.56e-8 Prostate cancer; LUSC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg25036284 chr2:26402008 FAM59B -0.69 -9.95 -0.48 1.35e-20 Gut microbiome composition (summer); LUSC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg17264618 chr3:40429014 ENTPD3 -0.3 -6.6 -0.34 1.58e-10 Renal cell carcinoma; LUSC cis rs12760731 0.565 rs57247289 chr1:178090138 G/A cg00404053 chr1:178313656 RASAL2 0.62 6.37 0.33 6.44e-10 Obesity-related traits; LUSC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg09263875 chr16:632152 PIGQ 0.71 13.33 0.59 8.23e-33 Height; LUSC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.61 12.9 0.58 3.53e-31 Monocyte percentage of white cells; LUSC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg11366901 chr6:160182831 ACAT2 0.83 11.5 0.53 5.19e-26 Age-related macular degeneration (geographic atrophy); LUSC cis rs868036 0.915 rs4489954 chr15:68072075 A/C cg05925327 chr15:68127851 NA 0.37 6.62 0.34 1.4e-10 Restless legs syndrome; LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.533 rs2120464 chr12:38280289 A/C cg26384229 chr12:38710491 ALG10B 0.56 8.52 0.42 5.64e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs7605827 0.930 rs1318980 chr2:15549890 G/T cg19274914 chr2:15703543 NA 0.46 8.88 0.44 4.23e-17 Educational attainment (years of education); LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.67 0.76 1.2e-65 Prudent dietary pattern; LUSC cis rs9513627 0.920 rs7334943 chr13:100121287 C/G cg25919922 chr13:100150906 NA 0.74 6.36 0.33 6.54e-10 Obesity-related traits; LUSC trans rs11250098 0.548 rs7843470 chr8:10784492 C/G cg15556689 chr8:8085844 FLJ10661 -0.53 -7.32 -0.37 1.83e-12 Morning vs. evening chronotype; LUSC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg26354017 chr1:205819088 PM20D1 0.42 5.68 0.3 2.99e-8 Parkinson's disease; LUSC cis rs7107174 0.681 rs10793301 chr11:78020913 G/T cg02023728 chr11:77925099 USP35 0.48 6.76 0.35 6.33e-11 Testicular germ cell tumor; LUSC cis rs2404602 0.735 rs56246286 chr15:76690731 C/T cg23625390 chr15:77176239 SCAPER -0.6 -9.36 -0.46 1.23e-18 Blood metabolite levels; LUSC cis rs2635047 0.904 rs2635046 chr18:44728429 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 5.77 0.3 1.8e-8 Educational attainment; LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC cis rs10203711 0.933 rs11885493 chr2:239584919 G/T cg14580085 chr2:239553406 NA 0.39 6.47 0.33 3.56e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.866 rs9995136 chr4:120286845 A/G cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg07677032 chr17:61819896 STRADA 0.52 8.7 0.43 1.53e-16 Prudent dietary pattern; LUSC cis rs73206853 0.609 rs61582364 chr12:110967847 T/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.5 0.38 5.91e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9372498 0.536 rs10484286 chr6:118956447 T/C cg18833306 chr6:118973337 C6orf204 -0.46 -5.84 -0.3 1.24e-8 Diastolic blood pressure; LUSC cis rs6977660 0.607 rs13239423 chr7:19816571 T/C cg07541023 chr7:19748670 TWISTNB 0.64 6.87 0.35 3.18e-11 Thyroid stimulating hormone; LUSC cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg06092702 chr1:163392909 NA 0.46 7.77 0.39 9.92e-14 Motion sickness; LUSC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg00074818 chr8:8560427 CLDN23 0.59 10.06 0.48 5.87e-21 Obesity-related traits; LUSC trans rs12699921 0.599 rs6973480 chr7:17978129 C/T cg23114746 chr17:47492438 PHB 0.39 6.01 0.31 4.83e-9 Fibrinogen levels; LUSC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg03806693 chr22:41940476 POLR3H -0.98 -13.99 -0.61 2.6e-35 Vitiligo; LUSC cis rs367943 1.000 rs348929 chr5:112814883 T/A cg12552261 chr5:112820674 MCC -0.44 -7.06 -0.36 9.68e-12 Type 2 diabetes; LUSC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.81 -0.39 7.7e-14 Reticulocyte count; LUSC cis rs2315504 0.626 rs769071 chr17:39030392 T/C cg17985300 chr17:38952333 KRT28 -0.3 -6.04 -0.31 4.19e-9 Height; LUSC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs6005807 0.719 rs12168765 chr22:29033308 G/C cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs10465746 0.967 rs28567085 chr1:84428859 G/A cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.01e-9 Obesity-related traits; LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 13.38 0.59 5.33e-33 Platelet count; LUSC cis rs41308713 0.606 rs77984335 chr20:37073286 G/A cg09132763 chr20:37064059 LOC388796;SNORA71D 0.93 6.36 0.33 6.65e-10 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs6084875 0.840 rs2422936 chr20:4720830 C/T cg26097573 chr20:4721490 PRNT -0.31 -5.7 -0.3 2.68e-8 Systemic lupus erythematosus; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.69 -0.5 3.93e-23 Alzheimer's disease; LUSC cis rs5758659 0.682 rs133306 chr22:42396150 G/A cg04733989 chr22:42467013 NAGA 0.39 6.54 0.34 2.32e-10 Cognitive function; LUSC trans rs629535 0.814 rs477200 chr8:70059584 A/G cg21567404 chr3:27674614 NA 0.9 13.79 0.6 1.46e-34 Dupuytren's disease; LUSC cis rs7100689 0.516 rs10887711 chr10:82034842 A/G cg01528321 chr10:82214614 TSPAN14 0.84 12.19 0.55 1.62e-28 Post bronchodilator FEV1; LUSC cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg02153584 chr22:29168773 CCDC117 0.59 8.92 0.44 3.05e-17 Lymphocyte counts; LUSC cis rs28647808 0.748 rs114667516 chr9:136258537 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs72901758 0.768 rs11657271 chr17:76249682 A/T cg11439826 chr17:76250004 NA 0.4 6.34 0.33 7.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs3781663 0.581 rs10793018 chr11:70004396 G/A cg06393558 chr11:69982916 ANO1 -0.41 -6.1 -0.32 2.9e-9 Survival in rectal cancer; LUSC trans rs9929218 0.954 rs34097984 chr16:68824148 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.09 -0.52 1.52e-24 Colorectal cancer; LUSC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg05425664 chr17:57184151 TRIM37 -0.53 -7.87 -0.4 5e-14 Intelligence (multi-trait analysis); LUSC cis rs9902453 0.817 rs2617881 chr17:28063275 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -9.22 -0.45 3.52e-18 Coffee consumption (cups per day); LUSC cis rs2486288 0.656 rs1719232 chr15:45572072 A/G cg09092052 chr15:45571596 NA 0.46 6.37 0.33 6.42e-10 Glomerular filtration rate; LUSC cis rs2729354 0.909 rs2729374 chr11:57326927 C/T cg24343310 chr11:57249947 NA 0.35 6.38 0.33 6.05e-10 Blood protein levels; LUSC cis rs7267979 1.000 rs1888998 chr20:25291826 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.73 -0.7 4.71e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg06219351 chr7:158114137 PTPRN2 -0.52 -9.57 -0.46 2.44e-19 Calcium levels; LUSC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg18240062 chr17:79603768 NPLOC4 0.78 15.33 0.64 1.6e-40 Eye color traits; LUSC cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg26384229 chr12:38710491 ALG10B 0.88 15.37 0.64 1.1e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs11676348 0.811 rs4674255 chr2:218987325 C/T cg06547715 chr2:218990976 CXCR2 0.33 6.49 0.33 3.15e-10 Ulcerative colitis; LUSC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22307029 chr19:49891270 CCDC155 0.69 9.55 0.46 2.9e-19 Multiple sclerosis; LUSC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg22875332 chr1:76189707 ACADM 0.86 15.91 0.66 7.83e-43 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9815354 0.951 rs9849393 chr3:41875369 G/C cg03022575 chr3:42003672 ULK4 0.64 7.02 0.36 1.21e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.07 -0.44 1.06e-17 Monocyte percentage of white cells; LUSC cis rs8040855 0.659 rs8037886 chr15:85686764 C/A cg04831495 chr15:85060580 GOLGA6L5 0.39 5.78 0.3 1.75e-8 Bulimia nervosa; LUSC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg11632617 chr15:75315747 PPCDC -0.52 -6.78 -0.35 5.39e-11 Blood trace element (Zn levels); LUSC cis rs7180079 1.000 rs7180079 chr15:64629873 A/G cg02848875 chr15:64387786 SNX1 0.41 5.84 0.3 1.27e-8 Monocyte count; LUSC cis rs1969363 0.531 rs11495331 chr12:38110702 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.74 0.35 6.83e-11 Morning vs. evening chronotype; LUSC cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg05347473 chr6:146136440 FBXO30 0.46 7.91 0.4 3.77e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs870825 0.616 rs67409049 chr4:185623989 G/A cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs709400 1.000 rs861539 chr14:104165753 G/A cg24130564 chr14:104152367 KLC1 -0.54 -7.8 -0.39 8.13e-14 Body mass index; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg03009463 chr7:17980271 SNX13 0.46 6.24 0.32 1.3e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs3741798 0.908 rs61922046 chr12:12495675 A/T cg08615371 chr12:12503544 MANSC1 1.09 11.15 0.52 9.57e-25 Cerebrospinal fluid biomarker levels; LUSC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.73 10.19 0.49 2.05e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 5.74 0.3 2.16e-8 Rheumatoid arthritis; LUSC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg04450456 chr4:17643702 FAM184B 0.35 5.81 0.3 1.47e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2404602 0.532 rs284892 chr15:76721037 A/G cg23625390 chr15:77176239 SCAPER 0.53 8.42 0.42 1.09e-15 Blood metabolite levels; LUSC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 7.33 0.37 1.76e-12 Hip circumference adjusted for BMI; LUSC cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg05555928 chr11:63887634 MACROD1 -0.48 -6.19 -0.32 1.74e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg15974085 chr18:71815641 C18orf55;FBXO15 -0.44 -6.24 -0.32 1.34e-9 Hepatitis; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs7647973 0.559 rs9586 chr3:49213637 C/T cg07636037 chr3:49044803 WDR6 0.59 7.13 0.36 6.16e-12 Menarche (age at onset); LUSC cis rs754133 0.507 rs10876531 chr12:54443718 A/C cg10005224 chr12:54424964 HOXC4;HOXC5 0.32 5.74 0.3 2.11e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg05082376 chr22:42548792 NA -0.42 -6.53 -0.34 2.48e-10 Schizophrenia; LUSC cis rs977987 0.806 rs11640473 chr16:75403289 C/A cg04384234 chr16:75411784 CFDP1 -0.42 -6.85 -0.35 3.47e-11 Dupuytren's disease; LUSC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg21138405 chr5:131827807 IRF1 0.32 5.81 0.3 1.46e-8 Breast cancer;Mosquito bite size; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.07 0.44 1.01e-17 Prudent dietary pattern; LUSC cis rs796364 0.662 rs11687313 chr2:201146399 G/A cg23649088 chr2:200775458 C2orf69 -0.57 -6.51 -0.34 2.83e-10 Schizophrenia; LUSC cis rs7824557 0.628 rs11250129 chr8:11202154 G/A cg21775007 chr8:11205619 TDH 0.8 13.44 0.59 3.1e-33 Retinal vascular caliber; LUSC cis rs2361718 0.590 rs4527052 chr17:78140910 A/G cg09238746 chr17:78121135 EIF4A3 -0.76 -11.32 -0.53 2.32e-25 Yeast infection; LUSC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg03354898 chr7:1950403 MAD1L1 -0.38 -7.37 -0.37 1.35e-12 Bipolar disorder and schizophrenia; LUSC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg24531977 chr5:56204891 C5orf35 -0.6 -8.9 -0.44 3.51e-17 Coronary artery disease; LUSC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg16928487 chr17:17741425 SREBF1 -0.45 -9.03 -0.44 1.41e-17 Total body bone mineral density; LUSC cis rs9905704 0.801 rs2013182 chr17:56637770 G/A cg12560992 chr17:57184187 TRIM37 -0.59 -8.46 -0.42 8.56e-16 Testicular germ cell tumor; LUSC trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg17470723 chr8:74884337 TCEB1 0.52 8.19 0.41 5.44e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs617219 0.819 rs2591389 chr5:78555208 C/T cg24856658 chr5:78533917 JMY -0.31 -5.95 -0.31 6.75e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs4700695 0.719 rs27079 chr5:65443966 C/T cg21114390 chr5:65439923 SFRS12 -0.63 -8.97 -0.44 2.12e-17 Facial morphology (factor 19); LUSC cis rs16912285 0.688 rs59246618 chr11:24315201 G/T ch.11.24196551F chr11:24239977 NA 0.91 9.97 0.48 1.15e-20 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg24549020 chr5:56110836 MAP3K1 0.49 5.81 0.3 1.46e-8 Initial pursuit acceleration; LUSC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.18 0.32 1.85e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs1728785 1.000 rs4783656 chr16:68580722 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs6785206 1.000 rs2712370 chr3:128425204 C/G cg16766828 chr3:128327626 NA -0.65 -6.91 -0.35 2.48e-11 Lymphocyte percentage of white cells; LUSC cis rs7481584 0.624 rs449164 chr11:3053454 C/T cg08508325 chr11:3079039 CARS 0.38 8.46 0.42 8.48e-16 Calcium levels; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg11645453 chr3:52864694 ITIH4 0.29 6.71 0.34 8.6e-11 Electroencephalogram traits; LUSC cis rs425277 1.000 rs262672 chr1:2080813 G/T cg24578937 chr1:2090814 PRKCZ 0.6 13.68 0.6 3.82e-34 Height; LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg08088566 chr11:430123 ANO9 0.66 7.31 0.37 1.98e-12 Body mass index; LUSC cis rs977987 0.806 rs1364077 chr16:75396991 C/T cg03315344 chr16:75512273 CHST6 0.48 9.18 0.45 4.78e-18 Dupuytren's disease; LUSC trans rs4927850 1.000 rs7627868 chr3:195753473 A/T cg21051086 chr3:73046214 PPP4R2 -0.52 -7.96 -0.4 2.63e-14 Pancreatic cancer; LUSC cis rs9790314 1.000 rs464766 chr3:161087592 C/G cg03342759 chr3:160939853 NMD3 -0.47 -7.75 -0.39 1.14e-13 Morning vs. evening chronotype; LUSC cis rs2562456 0.874 rs2562408 chr19:21709881 C/G cg00806126 chr19:22604979 ZNF98 0.38 5.91 0.31 8.64e-9 Pain; LUSC cis rs1858037 0.867 rs953312 chr2:65567690 C/T cg08085232 chr2:65598271 SPRED2 -0.39 -5.76 -0.3 1.87e-8 Rheumatoid arthritis; LUSC cis rs34779708 0.931 rs4934723 chr10:35381763 A/G cg04310649 chr10:35416472 CREM -0.43 -6.56 -0.34 2.02e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9549260 0.564 rs6563844 chr13:41298190 T/C cg21288729 chr13:41239152 FOXO1 0.52 7.74 0.39 1.23e-13 Red blood cell count; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg03414732 chr18:32870301 ZNF271;ZNF397OS 0.58 6.84 0.35 3.76e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7267979 0.565 rs6107059 chr20:25592431 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.59 -0.57 5.25e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Tonsillectomy; LUSC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg12311346 chr5:56204834 C5orf35 -0.82 -13.08 -0.58 7.72e-32 Coronary artery disease; LUSC trans rs7824557 0.628 rs11994376 chr8:11202960 G/A cg06636001 chr8:8085503 FLJ10661 0.45 6.55 0.34 2.11e-10 Retinal vascular caliber; LUSC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg26566898 chr11:117069891 TAGLN -0.48 -8.4 -0.42 1.29e-15 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15268184 chr6:170893863 PDCD2 -0.44 -6.59 -0.34 1.69e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs721399 0.542 rs10085931 chr8:18245449 A/G cg18736775 chr8:18248649 NAT2 -0.5 -5.87 -0.31 1.03e-8 Blood metabolite levels; LUSC cis rs6840360 0.571 rs2406976 chr4:152541056 G/C cg22705602 chr4:152727874 NA -0.32 -6.59 -0.34 1.73e-10 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg04944784 chr2:26401820 FAM59B -0.75 -11.0 -0.52 3.24e-24 Gut microbiome composition (summer); LUSC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg09021430 chr5:549028 NA -0.53 -7.47 -0.38 7.23e-13 Lung disease severity in cystic fibrosis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06188019 chr1:3541438 TPRG1L -0.42 -6.02 -0.31 4.5e-9 Electrocardiographic conduction measures; LUSC cis rs8077577 0.895 rs11654741 chr17:18124470 C/A cg16794390 chr17:18148240 FLII 0.42 5.81 0.3 1.43e-8 Obesity-related traits; LUSC cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg03146154 chr1:46216737 IPP 0.57 8.23 0.41 4.16e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg11645453 chr3:52864694 ITIH4 0.3 6.89 0.35 2.81e-11 Cognitive function; LUSC cis rs7584330 0.518 rs78856668 chr2:238438055 A/C cg14458575 chr2:238380390 NA 0.61 7.12 0.36 6.85e-12 Prostate cancer; LUSC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg04865166 chr7:105162814 PUS7 0.53 5.69 0.3 2.82e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg05623727 chr3:50126028 RBM5 0.31 5.73 0.3 2.27e-8 Body mass index; LUSC cis rs34734847 1.000 rs3021338 chr12:121162989 A/G cg21892295 chr12:121157589 UNC119B -0.52 -9.58 -0.46 2.37e-19 Mean corpuscular volume; LUSC cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.16 -0.45 5.33e-18 Monocyte percentage of white cells; LUSC cis rs80130819 0.748 rs10747531 chr12:48632280 A/G cg24011408 chr12:48396354 COL2A1 0.47 5.95 0.31 6.87e-9 Prostate cancer; LUSC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg00129232 chr17:37814104 STARD3 -0.47 -6.93 -0.35 2.19e-11 Asthma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00052422 chr3:41240987 CTNNB1 -0.41 -6.26 -0.32 1.15e-9 Electrocardiographic conduction measures; LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg02475777 chr4:1388615 CRIPAK 0.44 6.5 0.34 2.92e-10 Obesity-related traits; LUSC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg18252515 chr7:66147081 NA -1.25 -13.65 -0.6 5.24e-34 Diabetic kidney disease; LUSC cis rs9326248 0.581 rs10892063 chr11:116896155 A/C cg11861562 chr11:117069780 TAGLN 0.32 6.2 0.32 1.64e-9 Blood protein levels; LUSC cis rs2692947 0.740 rs60452119 chr2:96420050 T/C cg22654517 chr2:96458247 NA 0.37 7.48 0.38 6.63e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs722599 0.847 rs2058919 chr14:75310812 C/G cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.49 -0.38 6.35e-13 IgG glycosylation; LUSC cis rs7586879 0.765 rs11683429 chr2:25120733 T/A cg01884057 chr2:25150051 NA 0.43 8.95 0.44 2.49e-17 Body mass index; LUSC cis rs78572108 0.858 rs13384444 chr2:42265449 G/C cg00607755 chr2:42274082 PKDCC 0.36 6.52 0.34 2.61e-10 Total body bone mineral density; LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs870825 0.549 rs28542773 chr4:185617935 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg22532475 chr10:104410764 TRIM8 -0.39 -8.14 -0.41 8.16e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4285028 0.948 rs7651226 chr3:121670802 G/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.54 -0.46 3.19e-19 Multiple sclerosis; LUSC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7119 0.689 rs12907630 chr15:77812906 G/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.58 -0.34 1.82e-10 Type 2 diabetes; LUSC cis rs2857891 0.817 rs2239732 chr11:6976689 C/G cg04053776 chr11:6947353 ZNF215 0.42 5.82 0.3 1.39e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11644478 chr21:40555479 PSMG1 0.91 17.07 0.68 2.09e-47 Cognitive function; LUSC cis rs11190604 1.000 rs11190540 chr10:102202629 A/G cg07080220 chr10:102295463 HIF1AN 0.64 8.72 0.43 1.32e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs983392 0.709 rs2162254 chr11:60039917 T/A cg20284999 chr11:59952153 MS4A6A 0.39 6.48 0.33 3.2e-10 Alzheimer's disease (late onset); LUSC cis rs9486719 1.000 rs2142652 chr6:96868504 A/C cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg11608241 chr8:8085544 FLJ10661 -0.48 -6.75 -0.35 6.67e-11 Neuroticism; LUSC trans rs7607980 0.929 rs78970517 chr2:165554302 C/T cg21604450 chr1:66998563 SGIP1 0.54 6.18 0.32 1.84e-9 Fasting blood insulin (BMI interaction);Fasting blood insulin;Type 2 diabetes; LUSC cis rs9517320 1.000 rs9513430 chr13:99127252 C/G cg20487152 chr13:99095054 FARP1 0.34 6.3 0.33 9.42e-10 Longevity; LUSC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg08308459 chr2:38893161 GALM -0.57 -5.65 -0.3 3.41e-8 5-HTT brain serotonin transporter levels; LUSC cis rs757081 0.637 rs34941502 chr11:17155432 G/A cg15432903 chr11:17409602 KCNJ11 -0.38 -5.94 -0.31 7.29e-9 Systolic blood pressure; LUSC cis rs4786125 0.588 rs1473516 chr16:6923077 C/T cg03623568 chr16:6915990 A2BP1 -0.51 -8.43 -0.42 1.04e-15 Heart rate variability traits (SDNN); LUSC trans rs7824557 0.564 rs2736302 chr8:11236419 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.54 -0.38 4.51e-13 Retinal vascular caliber; LUSC cis rs8060686 0.668 rs8048034 chr16:68210604 A/G cg05110241 chr16:68378359 PRMT7 -0.47 -6.07 -0.32 3.45e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg22920501 chr2:26401640 FAM59B -0.74 -10.7 -0.51 3.63e-23 Gut microbiome composition (summer); LUSC cis rs35995292 0.857 rs6946859 chr7:38957432 A/G cg19327137 chr7:38886074 VPS41 0.35 5.7 0.3 2.62e-8 Subjective well-being (multi-trait analysis); LUSC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg18904891 chr8:8559673 CLDN23 0.6 8.35 0.42 1.8e-15 Obesity-related traits; LUSC cis rs4319547 0.737 rs10846921 chr12:122943376 G/T cg05707623 chr12:122985044 ZCCHC8 0.65 8.46 0.42 8.65e-16 Body mass index; LUSC cis rs612683 0.560 rs491675 chr1:100902936 A/G cg06223162 chr1:101003688 GPR88 0.43 7.9 0.4 4.09e-14 Breast cancer; LUSC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs4243830 0.850 rs12030607 chr1:6601007 T/A cg05709478 chr1:6581295 PLEKHG5 0.51 6.03 0.31 4.36e-9 Body mass index; LUSC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg16060761 chr17:80687452 NA -0.51 -8.01 -0.4 1.97e-14 Glycated hemoglobin levels; LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.89 0.35 2.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg17385448 chr1:15911702 AGMAT 0.34 5.68 0.3 2.97e-8 Systolic blood pressure; LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg19717773 chr7:2847554 GNA12 -0.38 -6.2 -0.32 1.68e-9 Height; LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.92 -13.81 -0.6 1.23e-34 Alzheimer's disease; LUSC cis rs887829 0.569 rs4663333 chr2:234655303 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.74 -0.39 1.16e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs6541297 1.000 rs6665367 chr1:230279169 G/A cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.22e-15 Coronary artery disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03916864 chr12:109535384 UNG -0.46 -7.07 -0.36 9.11e-12 Electrocardiographic conduction measures; LUSC cis rs9303401 0.659 rs62083410 chr17:56964386 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.18 0.58 3.19e-32 Cognitive test performance; LUSC cis rs11098499 0.955 rs56386062 chr4:120155135 T/C cg24375607 chr4:120327624 NA 0.75 11.42 0.53 9.94e-26 Corneal astigmatism; LUSC cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.6 -0.5 7.74e-23 Monocyte percentage of white cells; LUSC cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg05283184 chr6:79620031 NA -0.57 -12.02 -0.55 6.96e-28 Intelligence (multi-trait analysis); LUSC trans rs2243480 1.000 rs316304 chr7:65616894 T/C cg10756647 chr7:56101905 PSPH 0.88 8.91 0.44 3.39e-17 Diabetic kidney disease; LUSC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.75 10.67 0.5 4.63e-23 Cognitive test performance; LUSC cis rs4356932 0.656 rs13126007 chr4:76862255 G/A cg00809888 chr4:76862425 NAAA -0.36 -5.72 -0.3 2.36e-8 Blood protein levels; LUSC cis rs611744 0.647 rs7016198 chr8:109262752 G/A cg18478394 chr8:109455254 TTC35 0.44 6.81 0.35 4.63e-11 Dupuytren's disease; LUSC cis rs8032158 1.000 rs11632096 chr15:56210499 A/G cg02198044 chr15:56286336 NEDD4 -0.36 -5.72 -0.3 2.36e-8 Keloid; LUSC cis rs9905704 0.589 rs2632509 chr17:56487887 C/T cg19466818 chr17:56409534 MIR142 0.32 6.06 0.31 3.58e-9 Testicular germ cell tumor; LUSC cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg11266682 chr4:10021025 SLC2A9 0.58 10.41 0.49 3.7e-22 Bone mineral density; LUSC cis rs2762353 0.935 rs1165153 chr6:25817789 A/G cg12310025 chr6:25882481 NA -0.45 -7.8 -0.39 7.82e-14 Blood metabolite levels; LUSC cis rs11645898 1.000 rs11645898 chr16:72229532 A/G cg14768367 chr16:72042858 DHODH -0.57 -6.38 -0.33 5.78e-10 Blood protein levels; LUSC cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg13770153 chr20:60521292 NA -0.61 -8.39 -0.42 1.43e-15 Body mass index; LUSC cis rs17102423 0.661 rs45604339 chr14:65543102 C/T cg11161011 chr14:65562177 MAX -0.81 -12.02 -0.55 6.74e-28 Obesity-related traits; LUSC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg11366901 chr6:160182831 ACAT2 0.84 11.63 0.54 1.82e-26 Age-related macular degeneration (geographic atrophy); LUSC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg11871910 chr12:69753446 YEATS4 0.81 14.04 0.61 1.62e-35 Blood protein levels; LUSC cis rs1784581 0.507 rs1790020 chr6:162366266 C/T cg17173639 chr6:162384350 PARK2 -0.64 -10.92 -0.51 5.91e-24 Itch intensity from mosquito bite; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg27143824 chr4:184580738 C4orf41;RWDD4A 0.41 6.3 0.33 9.44e-10 Eotaxin levels; LUSC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.09 -0.36 8.04e-12 Intelligence (multi-trait analysis); LUSC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg08048268 chr3:133502702 NA 0.47 8.83 0.43 6.16e-17 Iron status biomarkers; LUSC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg26924012 chr15:45694286 SPATA5L1 1.12 20.66 0.75 1.16e-61 Homoarginine levels; LUSC cis rs1322512 1.000 rs2758777 chr6:153007467 G/T cg27316956 chr6:152958899 SYNE1 0.34 5.98 0.31 5.72e-9 Tonometry; LUSC cis rs4947962 0.617 rs1013127 chr7:55139068 A/G cg23757825 chr7:55092271 EGFR -0.5 -6.61 -0.34 1.56e-10 Subjective response to lithium treatment; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg11843238 chr5:131593191 PDLIM4 0.39 6.57 0.34 1.89e-10 Breast cancer; LUSC cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg24692254 chr21:30365293 RNF160 -0.69 -10.96 -0.51 4.4e-24 Pancreatic cancer; LUSC cis rs8017423 0.935 rs11624295 chr14:90695612 T/G cg04374321 chr14:90722782 PSMC1 0.72 11.5 0.53 5.41e-26 Mortality in heart failure; LUSC cis rs13082711 0.911 rs34422761 chr3:27513366 C/A cg02860705 chr3:27208620 NA 0.47 7.92 0.4 3.58e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs9462027 0.628 rs9348950 chr6:34673678 G/A cg07306190 chr6:34760872 UHRF1BP1 0.35 6.28 0.33 1.04e-9 Systemic lupus erythematosus; LUSC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs6840360 1.000 rs1105535 chr4:152605170 A/G cg22705602 chr4:152727874 NA -0.27 -5.74 -0.3 2.15e-8 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg13918804 chr1:2043761 PRKCZ 0.27 5.66 0.3 3.22e-8 Height; LUSC cis rs7584330 0.666 rs72620816 chr2:238353604 C/T cg14458575 chr2:238380390 NA 0.85 15.02 0.64 2.45e-39 Prostate cancer; LUSC cis rs17401966 0.838 rs12125535 chr1:10350849 T/A cg19773385 chr1:10388646 KIF1B -0.5 -8.66 -0.43 2.11e-16 Hepatocellular carcinoma; LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg22166914 chr1:53195759 ZYG11B 0.5 7.97 0.4 2.55e-14 Monocyte count; LUSC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs2637266 0.783 rs1797500 chr10:78510400 G/A cg18941641 chr10:78392320 NA 0.39 7.14 0.36 5.99e-12 Pulmonary function; LUSC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg23283495 chr1:209979779 IRF6 0.73 9.47 0.46 5.2e-19 Cleft lip with or without cleft palate; LUSC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg14558114 chr2:88469736 THNSL2 0.8 7.13 0.36 6.19e-12 Plasma clusterin levels; LUSC cis rs4319547 0.695 rs7301515 chr12:122949673 T/C cg23029597 chr12:123009494 RSRC2 -0.76 -9.55 -0.46 2.94e-19 Body mass index; LUSC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg08975724 chr8:8085496 FLJ10661 0.48 7.19 0.37 4.15e-12 Parkinson's disease; LUSC cis rs4969178 0.965 rs3817294 chr17:76396963 A/G cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11791136 chr19:42788257 CIC -0.44 -6.26 -0.32 1.21e-9 Electrocardiographic conduction measures; LUSC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 14.86 0.63 1.07e-38 Platelet count; LUSC cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg04455712 chr21:45112962 RRP1B 0.46 8.69 0.43 1.69e-16 Mean corpuscular volume; LUSC cis rs3806843 1.000 rs1030164 chr5:140185272 A/G cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg11584989 chr19:19387371 SF4 0.57 6.88 0.35 2.92e-11 Bipolar disorder; LUSC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg15605315 chr1:45957053 TESK2 0.51 8.54 0.42 4.98e-16 High light scatter reticulocyte count; LUSC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg22029157 chr1:209979665 IRF6 0.77 9.48 0.46 4.95e-19 Cleft lip with or without cleft palate; LUSC cis rs73198271 0.694 rs113694763 chr8:8647076 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.32 -0.33 8.29e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg22117172 chr7:91764530 CYP51A1 -0.33 -5.88 -0.31 9.88e-9 Breast cancer; LUSC cis rs11209002 0.592 rs4655672 chr1:67553543 C/T cg02640540 chr1:67518911 SLC35D1 0.65 9.14 0.45 6.23e-18 Crohn's disease; LUSC cis rs950169 0.840 rs62029595 chr15:84955301 C/T cg12863693 chr15:85201151 NMB 0.36 7.28 0.37 2.44e-12 Schizophrenia; LUSC cis rs9584850 0.834 rs745638 chr13:99119307 C/G cg07423050 chr13:99094983 FARP1 -0.39 -6.49 -0.33 3.02e-10 Neuroticism; LUSC cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg27446573 chr6:127587934 RNF146 0.92 15.3 0.64 2.12e-40 Breast cancer; LUSC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg20406979 chr6:167373233 NA -0.26 -6.16 -0.32 2.1e-9 Crohn's disease; LUSC cis rs71327718 1 rs71327718 chr3:125592857 C/G cg05084668 chr3:125655381 ALG1L -0.86 -11.84 -0.54 3.15e-27 Metabolite levels (HVA/5-HIAA ratio); LUSC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg04315214 chr1:2043799 PRKCZ 0.47 9.54 0.46 3.23e-19 Height; LUSC cis rs6582630 0.502 rs11520261 chr12:38332019 T/G cg13010199 chr12:38710504 ALG10B 0.62 9.48 0.46 4.72e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs2898681 0.618 rs116241740 chr4:53733523 A/G cg21521518 chr4:53727714 RASL11B 0.49 6.11 0.32 2.7e-9 Optic nerve measurement (cup area); LUSC cis rs636291 0.517 rs2781233 chr1:10529194 T/C cg17425144 chr1:10567563 PEX14 0.59 11.46 0.53 7.42e-26 Prostate cancer; LUSC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg26597838 chr10:835615 NA 1.23 16.89 0.68 1.03e-46 Eosinophil percentage of granulocytes; LUSC cis rs17604090 0.756 rs113829432 chr7:29725069 C/T cg19413766 chr7:29689036 LOC646762 -0.68 -8.5 -0.42 6.57e-16 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg15790184 chr11:494944 RNH1 0.53 6.05 0.31 3.83e-9 Body mass index; LUSC cis rs12900413 0.562 rs2118849 chr15:90302399 G/T cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg11742103 chr11:62369870 EML3;MTA2 0.48 7.18 0.37 4.7e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4604732 0.589 rs78689516 chr1:247626274 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs886126 0.761 rs10774615 chr12:111659096 T/C cg10833066 chr12:111807467 FAM109A 0.41 6.33 0.33 7.74e-10 Coronary heart disease; LUSC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg17948913 chr5:572064 NA 0.37 5.68 0.3 3.01e-8 Obesity-related traits; LUSC cis rs11758351 0.925 rs78932312 chr6:26194869 A/G cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs10465746 0.780 rs11163872 chr1:84421969 G/T cg10977910 chr1:84465055 TTLL7 0.46 6.71 0.34 8.3e-11 Obesity-related traits; LUSC cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg23788917 chr6:8435910 SLC35B3 0.51 7.58 0.38 3.38e-13 Motion sickness; LUSC cis rs1580019 0.885 rs4460269 chr7:32496445 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.66 0.54 1.35e-26 Cognitive ability; LUSC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg02549819 chr16:58548995 SETD6 0.96 9.04 0.44 1.29e-17 Schizophrenia; LUSC cis rs3772130 0.923 rs28674947 chr3:121529421 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.21 0.49 1.78e-21 Cognitive performance; LUSC cis rs7843479 0.965 rs2291317 chr8:21827162 C/T cg17168535 chr8:21777572 XPO7 0.68 10.54 0.5 1.25e-22 Mean corpuscular volume; LUSC cis rs7267979 1.000 rs4815418 chr20:25382211 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.84 -0.74 1.97e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs367615 0.552 rs2963010 chr5:108737043 T/C cg17395555 chr5:108820864 NA -0.5 -8.75 -0.43 1.1e-16 Colorectal cancer (SNP x SNP interaction); LUSC cis rs6577655 0.517 rs11998030 chr8:135585325 C/T cg17885191 chr8:135476712 NA 0.55 7.35 0.37 1.56e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2858942 0.602 rs1211375 chr16:240280 G/T cg00126636 chr16:237282 NA 0.44 6.91 0.35 2.51e-11 Mean corpuscular hemoglobin; LUSC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg03060546 chr3:49711283 APEH 0.7 11.5 0.53 5.08e-26 Resting heart rate; LUSC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg15448220 chr1:150897856 SETDB1 0.41 6.06 0.31 3.69e-9 Melanoma; LUSC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg04362960 chr10:104952993 NT5C2 0.52 6.54 0.34 2.35e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10782582 0.609 rs11584577 chr1:76242378 A/G cg10523679 chr1:76189770 ACADM -0.45 -6.5 -0.34 2.94e-10 Daytime sleep phenotypes; LUSC cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg04586622 chr2:25135609 ADCY3 0.43 9.06 0.44 1.09e-17 Body mass index; LUSC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg20203395 chr5:56204925 C5orf35 -0.58 -8.11 -0.41 9.99e-15 Initial pursuit acceleration; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -7.81 -0.39 7.61e-14 Longevity;Endometriosis; LUSC cis rs262150 0.501 rs2730206 chr7:158815173 G/C cg09826364 chr7:158789723 NA -0.38 -5.91 -0.31 8.56e-9 Facial morphology (factor 20); LUSC cis rs7089973 0.604 rs3758603 chr10:116605368 T/C cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg23281280 chr6:28129359 ZNF389 0.45 5.67 0.3 3.04e-8 Parkinson's disease; LUSC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg03396347 chr1:1875803 NA -0.55 -12.3 -0.56 6.11e-29 Body mass index; LUSC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg23719950 chr11:63933701 MACROD1 -0.62 -8.06 -0.4 1.42e-14 Mean platelet volume; LUSC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg09877947 chr5:131593287 PDLIM4 0.42 6.69 0.34 9.17e-11 Breast cancer;Mosquito bite size; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 2.92e-13 Prudent dietary pattern; LUSC cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg21770322 chr7:97807741 LMTK2 -0.49 -7.99 -0.4 2.29e-14 Breast cancer; LUSC cis rs7772486 0.743 rs111332144 chr6:146056681 C/T cg05347473 chr6:146136440 FBXO30 -0.38 -6.24 -0.32 1.35e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7809950 0.953 rs2253271 chr7:107201252 G/C cg23024343 chr7:107201750 COG5 -0.56 -8.88 -0.44 4.33e-17 Coronary artery disease; LUSC cis rs12541635 0.801 rs28709304 chr8:107106368 T/G cg10147462 chr8:107024639 NA -0.45 -7.99 -0.4 2.18e-14 Age of smoking initiation; LUSC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg05347473 chr6:146136440 FBXO30 0.52 9.04 0.44 1.29e-17 Lobe attachment (rater-scored or self-reported); LUSC trans rs208520 0.690 rs12194057 chr6:66745616 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.61 0.67 1.39e-45 Exhaled nitric oxide output; LUSC trans rs11657269 0.518 rs8070021 chr17:6326214 A/G cg04615859 chr17:7762123 CYB5D1;LSMD1 -0.34 -6.02 -0.31 4.67e-9 TRAIL levels; LUSC cis rs7123876 0.587 rs11601122 chr11:72362718 A/G cg03713592 chr11:72463424 ARAP1 0.76 8.01 0.4 1.88e-14 Body mass index; LUSC cis rs10189230 0.967 rs7573758 chr2:222357326 G/T cg14652038 chr2:222343519 EPHA4 0.32 5.71 0.3 2.46e-8 Urate levels in lean individuals; LUSC cis rs9473147 0.516 rs9463342 chr6:47585106 A/T cg20196966 chr6:47445060 CD2AP 0.43 6.08 0.32 3.24e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs4268898 0.527 rs72789910 chr2:24388609 T/G cg06627628 chr2:24431161 ITSN2 -0.86 -11.73 -0.54 7.69e-27 Asthma; LUSC cis rs9303401 0.659 rs62083525 chr17:56658088 A/G cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs472402 0.560 rs2288444 chr5:6619923 A/G cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.51 -7.41 -0.38 1.06e-12 Response to amphetamines; LUSC cis rs2708377 0.860 rs2708336 chr12:11273406 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC trans rs208515 0.525 rs10944869 chr6:66687576 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.02 14.05 0.61 1.55e-35 Exhaled nitric oxide levels; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg08736216 chr1:53307985 ZYG11A -0.3 -6.17 -0.32 2.03e-9 Monocyte count; LUSC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg09858108 chr8:58055024 NA 0.45 6.16 0.32 2.11e-9 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.534 rs4931783 chr12:34115322 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.4 0.53 1.19e-25 Morning vs. evening chronotype; LUSC cis rs7589342 0.839 rs12997003 chr2:106436413 C/T cg16077055 chr2:106428750 NCK2 0.38 7.18 0.37 4.52e-12 Addiction; LUSC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs861020 0.771 rs661849 chr1:210001233 C/T cg05527609 chr1:210001259 C1orf107 1.03 14.75 0.63 2.95e-38 Orofacial clefts; LUSC cis rs8072548 1 rs8072548 chr17:38164025 T/G cg26162295 chr17:38119207 GSDMA -0.26 -6.07 -0.32 3.55e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs66716358 0.676 rs1869481 chr11:44319905 T/C cg16977035 chr11:44330474 ALX4 -0.34 -5.76 -0.3 1.88e-8 Monobrow; LUSC cis rs7188861 0.768 rs529866 chr16:11373320 A/G cg00044050 chr16:11439710 C16orf75 -0.54 -6.18 -0.32 1.82e-9 HDL cholesterol; LUSC cis rs61990749 0.544 rs12435761 chr14:78246077 C/G cg02301378 chr14:78227641 SNW1;C14orf178 0.61 6.69 0.34 9.25e-11 Fibroblast growth factor basic levels; LUSC cis rs9467711 0.606 rs9379854 chr6:26362854 T/C cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg09365446 chr1:150670422 GOLPH3L 0.53 8.01 0.4 1.9e-14 Melanoma; LUSC cis rs3755132 0.929 rs16862799 chr2:15742260 G/A cg12888861 chr2:15731646 DDX1 0.5 7.36 0.37 1.41e-12 Wilms tumor; LUSC trans rs11148252 0.500 rs342768 chr13:53208882 C/T cg18335740 chr13:41363409 SLC25A15 0.77 13.73 0.6 2.47e-34 Lewy body disease; LUSC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg27266027 chr21:40555129 PSMG1 -0.4 -5.84 -0.3 1.24e-8 Cognitive function; LUSC cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg26924012 chr15:45694286 SPATA5L1 1.01 16.17 0.66 7.93e-44 Homoarginine levels; LUSC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -6.43 -0.33 4.39e-10 Developmental language disorder (linguistic errors); LUSC cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg11102782 chr19:18549136 ISYNA1 -0.36 -6.89 -0.35 2.82e-11 Breast cancer; LUSC cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg23711669 chr6:146136114 FBXO30 0.76 13.64 0.6 5.66e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs10435719 0.867 rs62493601 chr8:11788307 C/T cg21775007 chr8:11205619 TDH 0.47 6.71 0.34 8.45e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7177699 0.550 rs4468572 chr15:79124475 C/T cg15571903 chr15:79123663 NA -0.31 -5.84 -0.3 1.25e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2281845 0.533 rs10753891 chr1:201100482 A/G cg06714761 chr1:201096289 NA 0.37 7.33 0.37 1.78e-12 Permanent tooth development; LUSC cis rs936229 0.813 rs72730503 chr15:75086386 G/A cg14664628 chr15:75095509 CSK -1.01 -17.02 -0.68 3.11e-47 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs8061121 1.000 rs8061121 chr16:87193084 A/G cg10047845 chr16:87184939 NA 0.49 5.69 0.3 2.8e-8 Congenital left-sided heart lesions; LUSC trans rs9393777 0.841 rs34332556 chr6:27357414 C/G cg01620082 chr3:125678407 NA -0.78 -6.87 -0.35 3.13e-11 Intelligence (multi-trait analysis); LUSC cis rs2880765 0.835 rs7180923 chr15:86050890 A/T cg13263323 chr15:86062960 AKAP13 -0.34 -5.65 -0.3 3.37e-8 Coronary artery disease; LUSC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.49 6.13 0.32 2.43e-9 Schizophrenia; LUSC cis rs9534288 0.912 rs3736944 chr13:46619316 T/C cg15192986 chr13:46630673 CPB2 -0.74 -11.41 -0.53 1.1e-25 Blood protein levels; LUSC cis rs2404602 0.692 rs34181263 chr15:77065388 C/T cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.82e-12 Blood metabolite levels; LUSC cis rs9611565 0.649 rs139540 chr22:42178040 C/T cg03806693 chr22:41940476 POLR3H -0.81 -11.41 -0.53 1.12e-25 Vitiligo; LUSC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -7.35 -0.37 1.51e-12 Developmental language disorder (linguistic errors); LUSC cis rs8078723 1.000 rs59925331 chr17:38169273 C/G cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.93 -0.35 2.15e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg05347473 chr6:146136440 FBXO30 -0.41 -6.91 -0.35 2.48e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg11494091 chr17:61959527 GH2 0.64 13.57 0.6 1.06e-33 Prudent dietary pattern; LUSC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.83 -0.35 3.97e-11 Crohn's disease; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg26102512 chr17:1619670 WDR81;C17orf91 -0.49 -6.34 -0.33 7.4e-10 Cognitive function;Information processing speed; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg15790184 chr11:494944 RNH1 0.61 6.44 0.33 4.27e-10 Body mass index; LUSC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.45 0.46 5.93e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11098499 0.661 rs10015965 chr4:120268237 A/G cg09307838 chr4:120376055 NA 0.64 9.62 0.47 1.69e-19 Corneal astigmatism; LUSC cis rs2274273 0.837 rs11625968 chr14:55801004 G/C cg04306507 chr14:55594613 LGALS3 0.57 12.71 0.57 1.92e-30 Protein biomarker; LUSC cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.98 0.55 9.29e-28 Chronic sinus infection; LUSC cis rs7119 0.689 rs11630557 chr15:77820712 A/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.55 -0.34 2.14e-10 Type 2 diabetes; LUSC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg02569458 chr12:86230093 RASSF9 0.6 10.37 0.49 5.12e-22 Major depressive disorder; LUSC trans rs7824557 0.736 rs35392635 chr8:11164349 G/C cg06636001 chr8:8085503 FLJ10661 0.52 7.82 0.39 7.09e-14 Retinal vascular caliber; LUSC cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg04586622 chr2:25135609 ADCY3 0.4 8.31 0.41 2.39e-15 Body mass index in non-asthmatics; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg22963979 chr7:1858916 MAD1L1 -0.59 -9.26 -0.45 2.51e-18 Bipolar disorder and schizophrenia; LUSC cis rs7953249 0.656 rs2243616 chr12:121406370 G/T cg25281562 chr12:121454272 C12orf43 -0.43 -5.79 -0.3 1.64e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC trans rs9951602 0.512 rs4798994 chr18:76654327 T/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs7760535 0.794 rs12529158 chr6:111822447 C/T cg22127309 chr6:111907043 TRAF3IP2 0.4 7.56 0.38 3.95e-13 Metabolic traits; LUSC cis rs7192380 0.964 rs55780735 chr16:69740374 A/G cg26679644 chr16:69762563 NA -0.36 -6.16 -0.32 2.04e-9 Sjögren's syndrome; LUSC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.85 0.63 1.19e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg12463550 chr7:65579703 CRCP 0.5 7.02 0.36 1.22e-11 Aortic root size; LUSC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC cis rs2637266 0.686 rs1660915 chr10:78525318 T/A cg18941641 chr10:78392320 NA 0.38 7.02 0.36 1.23e-11 Pulmonary function; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg08088566 chr11:430123 ANO9 -0.63 -7.3 -0.37 2.12e-12 Body mass index; LUSC cis rs7072216 0.770 rs1061115 chr10:100177049 G/A cg26618903 chr10:100175079 PYROXD2 -0.35 -6.97 -0.36 1.75e-11 Metabolite levels; LUSC trans rs8072100 0.744 rs34537623 chr17:45530203 A/G cg04995722 chr7:26192034 NFE2L3 -0.37 -6.07 -0.32 3.38e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12701220 0.842 rs10236293 chr7:1032637 G/A cg00990874 chr7:1149470 C7orf50 -0.5 -5.97 -0.31 5.96e-9 Bronchopulmonary dysplasia; LUSC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg12463550 chr7:65579703 CRCP -0.52 -7.55 -0.38 4.21e-13 Aortic root size; LUSC cis rs1950626 0.705 rs34991312 chr14:101435167 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.77 0.39 9.83e-14 Pelvic organ prolapse (moderate/severe); LUSC cis rs4631830 0.720 rs2611512 chr10:51515534 A/G cg16070123 chr10:51489643 NA -0.55 -9.01 -0.44 1.59e-17 Prostate-specific antigen levels; LUSC cis rs11098499 0.909 rs11723757 chr4:120299669 C/T cg24375607 chr4:120327624 NA 0.77 11.25 0.52 4.16e-25 Corneal astigmatism; LUSC cis rs56235845 0.665 rs4976685 chr5:176766177 C/T cg16006841 chr5:176797999 RGS14 -0.65 -10.37 -0.49 4.94e-22 Hemoglobin concentration;Hematocrit; LUSC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg17724175 chr1:150552817 MCL1 0.37 6.77 0.35 5.97e-11 Tonsillectomy; LUSC cis rs4969178 0.622 rs4129767 chr17:76403984 G/A cg05887092 chr17:76393375 PGS1 0.62 11.81 0.54 3.85e-27 HDL cholesterol levels; LUSC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg22903471 chr2:27725779 GCKR -0.41 -7.01 -0.36 1.34e-11 Menopause (age at onset); LUSC cis rs7927592 0.913 rs55883802 chr11:68278829 G/A cg20283391 chr11:68216788 NA -0.61 -8.55 -0.42 4.43e-16 Total body bone mineral density; LUSC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg20243544 chr17:37824526 PNMT 0.57 7.77 0.39 9.72e-14 Glomerular filtration rate (creatinine); LUSC cis rs9326248 0.520 rs2735183 chr11:117015195 C/T cg26566898 chr11:117069891 TAGLN 0.33 6.33 0.33 7.76e-10 Blood protein levels; LUSC cis rs2439831 1.000 rs2467740 chr15:43746792 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.89 0.44 3.9e-17 Lung cancer in ever smokers; LUSC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg25019033 chr10:957182 NA -0.5 -6.28 -0.32 1.07e-9 Eosinophil percentage of granulocytes; LUSC cis rs9420 0.925 rs488769 chr11:57450720 A/C cg02958346 chr11:57425731 CLP1 -0.43 -6.27 -0.32 1.09e-9 Schizophrenia; LUSC cis rs7677751 0.806 rs7673853 chr4:55096606 T/C cg17187183 chr4:55093834 PDGFRA 0.39 5.89 0.31 9.61e-9 Corneal astigmatism; LUSC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg06481639 chr22:41940642 POLR3H -0.52 -5.98 -0.31 5.75e-9 Vitiligo; LUSC cis rs6469656 0.892 rs6469658 chr8:117685265 A/C cg24004040 chr8:117650383 NA -0.45 -6.62 -0.34 1.45e-10 Colorectal cancer; LUSC cis rs6964587 1.000 rs6970277 chr7:91680655 T/C cg22709100 chr7:91322751 NA 0.42 6.16 0.32 2.09e-9 Breast cancer; LUSC cis rs12760731 0.623 rs1342848 chr1:178296461 A/G cg00404053 chr1:178313656 RASAL2 0.47 5.81 0.3 1.48e-8 Obesity-related traits; LUSC cis rs9393777 0.623 rs56296968 chr6:26474571 C/T cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg09085632 chr11:111637200 PPP2R1B -1.05 -17.16 -0.68 8.97e-48 Primary sclerosing cholangitis; LUSC cis rs1775715 0.769 rs2799030 chr10:32172935 G/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.62e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.34e-8 Diabetic kidney disease; LUSC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg12927641 chr6:109611667 NA -0.36 -6.14 -0.32 2.38e-9 Reticulocyte fraction of red cells; LUSC cis rs5758659 0.819 rs134871 chr22:42652716 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.29 -6.09 -0.32 3.13e-9 Cognitive function; LUSC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg09904177 chr6:26538194 HMGN4 -0.53 -6.37 -0.33 6.43e-10 Intelligence (multi-trait analysis); LUSC cis rs2070433 0.706 rs2268524 chr21:47838700 C/T cg12379764 chr21:47803548 PCNT 0.76 8.92 0.44 3.04e-17 Lymphocyte counts; LUSC cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg07061783 chr6:25882402 NA 0.43 6.1 0.32 2.89e-9 Blood metabolite levels; LUSC cis rs9486719 1.000 rs11152951 chr6:96894135 C/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs921968 0.541 rs549026 chr2:219339283 T/C cg02176678 chr2:219576539 TTLL4 0.74 14.33 0.62 1.24e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs9677476 0.779 rs10177091 chr2:232109889 C/T cg07929768 chr2:232055508 NA 0.37 6.27 0.32 1.09e-9 Food antigen IgG levels; LUSC cis rs56283067 0.847 rs10807302 chr6:44710152 G/C cg20913747 chr6:44695427 NA -0.5 -8.31 -0.41 2.46e-15 Total body bone mineral density; LUSC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg09033563 chr22:24373618 LOC391322 -0.49 -6.82 -0.35 4.29e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.2 0.52 6.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg03878208 chr11:72483293 STARD10 0.37 5.79 0.3 1.67e-8 Body mass index; LUSC cis rs11098499 0.954 rs56270433 chr4:120406030 C/T cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.57e-25 Corneal astigmatism; LUSC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg11663144 chr21:46675770 NA -0.37 -6.01 -0.31 4.98e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg27446573 chr6:127587934 RNF146 0.81 12.97 0.58 1.93e-31 Breast cancer; LUSC cis rs9300255 0.596 rs11057207 chr12:123730891 T/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.83 -0.35 4.1e-11 Neutrophil percentage of white cells; LUSC cis rs7189233 0.955 rs7184800 chr16:53509131 G/A cg09728985 chr16:53543985 NA -0.35 -6.31 -0.33 8.82e-10 Intelligence (multi-trait analysis); LUSC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg09703963 chr11:616879 IRF7;MUPCDH -0.45 -7.1 -0.36 7.32e-12 Systemic lupus erythematosus; LUSC cis rs9473147 0.516 rs13212790 chr6:47576367 T/C cg12968598 chr6:47444699 CD2AP 0.53 8.13 0.41 8.66e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg18876405 chr7:65276391 NA 0.54 8.24 0.41 3.93e-15 Aortic root size; LUSC cis rs9362426 0.943 rs242291 chr6:88077083 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -5.71 -0.3 2.44e-8 Depressive episodes in bipolar disorder; LUSC cis rs6690583 0.623 rs61769366 chr1:85534062 G/A cg11262906 chr1:85462892 MCOLN2 0.69 5.78 0.3 1.71e-8 Serum sulfate level; LUSC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg26335602 chr6:28129616 ZNF389 -0.45 -6.14 -0.32 2.39e-9 Depression; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14295955 chr11:57479323 MED19;TMX2 0.44 6.45 0.33 3.89e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg04518342 chr5:131593106 PDLIM4 0.32 5.73 0.3 2.27e-8 Blood metabolite levels; LUSC cis rs10197940 0.624 rs10497082 chr2:152355258 T/C cg19508488 chr2:152266495 RIF1 0.54 7.74 0.39 1.21e-13 Lung cancer; LUSC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg10802521 chr3:52805072 NEK4 0.43 5.87 0.31 1.05e-8 Bipolar disorder; LUSC cis rs8048589 0.615 rs34598762 chr16:12234958 A/G cg02910054 chr16:12241554 SNX29 0.48 5.94 0.31 7.35e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg01475377 chr6:109611718 NA -0.46 -8.37 -0.42 1.59e-15 Reticulocyte fraction of red cells; LUSC cis rs7512552 0.780 rs1260411 chr1:150382088 G/A cg15654264 chr1:150340011 RPRD2 0.63 10.4 0.49 3.9e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9303542 0.559 rs1042818 chr17:46620111 T/C cg09704116 chr17:46666958 LOC404266 -0.38 -6.54 -0.34 2.34e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg00376283 chr12:123451042 ABCB9 -0.6 -7.42 -0.38 9.79e-13 Neutrophil percentage of white cells; LUSC cis rs2303282 0.690 rs2550302 chr16:56392932 C/T cg00500540 chr16:56394104 NA -0.43 -7.42 -0.38 9.82e-13 Breast cancer; LUSC cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg02175503 chr12:58329896 NA 0.75 11.4 0.53 1.16e-25 Intelligence (multi-trait analysis); LUSC cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.58 -0.46 2.27e-19 Body mass index; LUSC cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg04990556 chr1:26633338 UBXN11 -0.45 -5.97 -0.31 5.9e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7107174 1.000 rs4944195 chr11:78003499 T/C cg02023728 chr11:77925099 USP35 0.49 6.87 0.35 3.11e-11 Testicular germ cell tumor; LUSC cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.96 13.78 0.6 1.66e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs367943 0.712 rs6867397 chr5:112725759 C/T cg12552261 chr5:112820674 MCC -0.37 -6.0 -0.31 5.14e-9 Type 2 diabetes; LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg24675658 chr1:53192096 ZYG11B 0.59 9.22 0.45 3.51e-18 Monocyte count; LUSC cis rs1728785 1.000 rs1728780 chr16:68567642 G/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg16928487 chr17:17741425 SREBF1 -0.35 -6.54 -0.34 2.3e-10 Total body bone mineral density; LUSC cis rs11166629 1.000 rs1036820 chr8:135646571 C/T cg21672855 chr8:135614777 ZFAT -0.36 -5.84 -0.3 1.26e-8 Smoking quantity; LUSC cis rs140330585 1 rs140330585 chr15:78866445 G/A cg18825076 chr15:78729989 IREB2 -0.5 -7.86 -0.39 5.49e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg09184832 chr6:79620586 NA -0.44 -7.01 -0.36 1.33e-11 Intelligence (multi-trait analysis); LUSC cis rs644799 0.526 rs534973 chr11:95633624 A/T cg25622487 chr11:95524042 FAM76B;CEP57 0.62 9.3 0.45 1.84e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs6496044 0.568 rs4842888 chr15:86063133 C/T cg13263323 chr15:86062960 AKAP13 0.37 6.14 0.32 2.35e-9 Interstitial lung disease; LUSC cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg13010199 chr12:38710504 ALG10B 0.69 11.39 0.53 1.28e-25 Heart rate; LUSC cis rs11098499 0.866 rs12510451 chr4:120289143 C/T cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs9399135 0.935 rs11754504 chr6:135321509 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.12 0.45 7.4e-18 Red blood cell count; LUSC cis rs3806843 1.000 rs3822346 chr5:140187322 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03576123 chr11:487126 PTDSS2 -1.06 -11.69 -0.54 1.08e-26 Body mass index; LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg18758796 chr5:131593413 PDLIM4 0.44 7.24 0.37 3.2e-12 Acylcarnitine levels; LUSC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg09365446 chr1:150670422 GOLPH3L -0.54 -7.78 -0.39 9.17e-14 Urate levels; LUSC cis rs9513627 0.665 rs79036236 chr13:100116405 C/T cg25919922 chr13:100150906 NA -0.78 -6.34 -0.33 7.42e-10 Obesity-related traits; LUSC cis rs9747201 1.000 rs62078307 chr17:80090053 G/T cg17462356 chr17:80056334 FASN 0.45 6.07 0.32 3.54e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg24675658 chr1:53192096 ZYG11B -0.62 -10.25 -0.49 1.31e-21 Monocyte count; LUSC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg05754148 chr16:3507555 NAT15 0.8 9.51 0.46 3.86e-19 Tuberculosis; LUSC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.63 -8.2 -0.41 5.18e-15 Schizophrenia; LUSC cis rs3772130 0.962 rs6776670 chr3:121543120 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.68 10.31 0.49 7.77e-22 Cognitive performance; LUSC cis rs2797160 0.651 rs6569436 chr6:126032104 A/G cg05901451 chr6:126070800 HEY2 0.77 12.49 0.56 1.24e-29 Endometrial cancer; LUSC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg16423285 chr20:60520624 NA -0.46 -5.71 -0.3 2.45e-8 Body mass index; LUSC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg03806693 chr22:41940476 POLR3H -0.96 -12.87 -0.58 4.78e-31 Vitiligo; LUSC cis rs79349575 0.756 rs3848460 chr17:47047114 A/G cg22482690 chr17:47019901 SNF8 -0.39 -7.39 -0.37 1.18e-12 Type 2 diabetes; LUSC cis rs56283067 0.577 rs114009236 chr6:44897517 T/C cg18551225 chr6:44695536 NA -0.48 -7.86 -0.4 5.3e-14 Total body bone mineral density; LUSC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg01448562 chr3:133502909 NA -0.76 -13.24 -0.59 1.95e-32 Iron status biomarkers; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg02018176 chr4:1364513 KIAA1530 0.51 8.83 0.44 5.97e-17 Obesity-related traits; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg22903657 chr4:1355424 KIAA1530 -0.4 -6.8 -0.35 4.85e-11 Longevity; LUSC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.42 6.35 0.33 6.91e-10 Intelligence (multi-trait analysis); LUSC cis rs9311676 0.632 rs11130630 chr3:58360800 A/G cg13750441 chr3:58318267 PXK 0.34 6.66 0.34 1.1e-10 Systemic lupus erythematosus; LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg07507251 chr3:52567010 NT5DC2 0.34 6.66 0.34 1.1e-10 Bipolar disorder; LUSC cis rs9549367 1.000 rs9549367 chr13:113911532 C/G cg18105134 chr13:113819100 PROZ -0.63 -9.28 -0.45 2.19e-18 Platelet distribution width; LUSC trans rs62238980 0.614 rs75526838 chr22:32451830 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs1448094 0.872 rs7314272 chr12:86401005 T/C cg18827107 chr12:86230957 RASSF9 -0.38 -5.67 -0.3 3.15e-8 Major depressive disorder; LUSC cis rs6961069 0.645 rs7795092 chr7:80227548 T/C cg04458919 chr7:80252533 CD36 -0.41 -7.24 -0.37 3.12e-12 Platelet count; LUSC cis rs748404 0.697 rs501884 chr15:43553982 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.88 0.31 1e-8 Lung cancer; LUSC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg07424592 chr7:64974309 NA 0.65 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs10979 0.894 rs6924940 chr6:143906183 C/T cg25407410 chr6:143891975 LOC285740 -0.64 -9.76 -0.47 5.96e-20 Hypospadias; LUSC cis rs7178572 0.633 rs907369 chr15:77843560 A/G cg22256960 chr15:77711686 NA -0.49 -7.38 -0.37 1.29e-12 Type 2 diabetes; LUSC cis rs7572644 0.564 rs12995865 chr2:28025066 A/C cg27432699 chr2:27873401 GPN1 0.56 7.3 0.37 2.09e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11890956 chr21:40555474 PSMG1 0.91 16.67 0.67 7.86e-46 Cognitive function; LUSC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg06850241 chr22:41845214 NA 0.34 6.15 0.32 2.25e-9 Vitiligo; LUSC cis rs62408225 1.000 rs6454805 chr6:90986353 A/G cg06866423 chr6:90926672 BACH2 0.4 5.78 0.3 1.75e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs13394619 0.775 rs10200851 chr2:11722082 C/T cg07314298 chr2:11723111 GREB1 -0.54 -9.4 -0.46 9.12e-19 Endometriosis; LUSC cis rs7119 0.651 rs12904823 chr15:77837662 G/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.41 -0.33 4.82e-10 Type 2 diabetes; LUSC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6977660 0.507 rs72591448 chr7:19775298 C/T cg05791153 chr7:19748676 TWISTNB 0.85 8.49 0.42 6.86e-16 Thyroid stimulating hormone; LUSC cis rs7940866 0.740 rs2162060 chr11:130830763 A/G cg12179176 chr11:130786555 SNX19 0.65 9.8 0.47 4.14e-20 Schizophrenia; LUSC cis rs1997103 0.871 rs1997101 chr7:55399652 A/T cg17469321 chr7:55412551 NA 0.65 10.41 0.5 3.51e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg06454157 chr6:167490870 NA -0.26 -6.08 -0.32 3.25e-9 Crohn's disease; LUSC trans rs11098499 0.954 rs17009122 chr4:120362403 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.12 0.41 9.17e-15 Corneal astigmatism; LUSC cis rs9399401 0.593 rs262117 chr6:142807093 G/A cg03128060 chr6:142623767 GPR126 0.56 9.28 0.45 2.21e-18 Chronic obstructive pulmonary disease; LUSC trans rs12050412 1.000 rs12050412 chr14:83378003 G/T cg25644150 chr5:133968296 SAR1B -0.44 -6.16 -0.32 2.06e-9 Word reading; LUSC cis rs12541491 0.506 rs11250007 chr8:10285086 C/G cg02319733 chr8:10282549 MSRA -0.35 -5.84 -0.3 1.21e-8 Schizophrenia; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg23131131 chr22:24373011 LOC391322 -0.4 -5.86 -0.31 1.12e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs35883536 0.647 rs10875314 chr1:101043207 G/C cg06223162 chr1:101003688 GPR88 -0.48 -9.03 -0.44 1.4e-17 Monocyte count; LUSC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg02574844 chr11:5959923 NA -0.4 -5.76 -0.3 1.95e-8 DNA methylation (variation); LUSC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg06671706 chr8:8559999 CLDN23 0.51 6.71 0.34 8.45e-11 Obesity-related traits; LUSC cis rs10740039 0.883 rs10740038 chr10:62403237 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.38e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg20573242 chr4:122745356 CCNA2 0.6 8.45 0.42 9.21e-16 Type 2 diabetes; LUSC cis rs2073300 1.000 rs6036411 chr20:23441706 A/C cg09953122 chr20:23471693 CST8 -0.8 -7.42 -0.38 9.81e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs858239 0.632 rs7811903 chr7:23119056 A/G cg23682824 chr7:23144976 KLHL7 0.4 5.83 0.3 1.27e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs9303280 0.936 rs907091 chr17:37921742 A/G cg20243544 chr17:37824526 PNMT 0.4 6.14 0.32 2.38e-9 Self-reported allergy; LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg20887711 chr4:1340912 KIAA1530 0.43 6.71 0.34 8.29e-11 Obesity-related traits; LUSC cis rs1941023 0.503 rs7952244 chr11:60132164 G/A cg08716584 chr11:60157161 MS4A7 -0.63 -11.76 -0.54 5.85e-27 Congenital heart disease (maternal effect); LUSC trans rs7395662 0.591 rs11039766 chr11:48488715 T/C cg15704280 chr7:45808275 SEPT13 -0.44 -6.0 -0.31 5.15e-9 HDL cholesterol; LUSC cis rs5769707 0.681 rs8137111 chr22:50043750 G/A cg20744362 chr22:50050164 C22orf34 0.39 7.29 0.37 2.23e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs477692 0.905 rs7905466 chr10:131438937 A/T cg05714579 chr10:131428358 MGMT -0.49 -7.45 -0.38 7.85e-13 Response to temozolomide; LUSC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg06008330 chr7:65541103 ASL 0.4 6.14 0.32 2.29e-9 Aortic root size; LUSC cis rs147499554 1 rs147499554 chr15:78900650 C/T cg18825076 chr15:78729989 IREB2 -0.51 -7.91 -0.4 3.77e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.42 0.5 3.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs2229238 0.911 rs4390168 chr1:154509096 A/G cg25273160 chr11:56955011 LRRC55 0.32 6.11 0.32 2.79e-9 Coronary heart disease; LUSC trans rs35110281 0.591 rs162369 chr21:44931965 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.2 0.49 1.84e-21 Mean corpuscular volume; LUSC cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg23711669 chr6:146136114 FBXO30 0.76 13.47 0.59 2.45e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg02018176 chr4:1364513 KIAA1530 0.56 9.74 0.47 6.96e-20 Longevity; LUSC trans rs6951245 0.935 rs61753396 chr7:1105372 A/G cg13565492 chr6:43139072 SRF -0.62 -6.56 -0.34 2.09e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8018808 0.935 rs8018513 chr14:77928288 T/C cg20045696 chr14:77926864 AHSA1 0.34 5.73 0.3 2.28e-8 Myeloid white cell count; LUSC cis rs9807989 0.507 rs6710034 chr2:103023678 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg14582100 chr15:45693742 SPATA5L1 0.59 10.42 0.5 3.31e-22 Homoarginine levels; LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg00945038 chr17:61921165 SMARCD2 0.54 9.57 0.46 2.42e-19 Prudent dietary pattern; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg05564831 chr3:52568323 NT5DC2 0.36 6.54 0.34 2.31e-10 Electroencephalogram traits; LUSC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg00701064 chr4:6280414 WFS1 0.51 10.78 0.51 1.87e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.95 -13.24 -0.59 1.83e-32 Platelet count; LUSC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg19346786 chr7:2764209 NA -0.5 -8.31 -0.41 2.47e-15 Height; LUSC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg04998671 chr14:104000505 TRMT61A -0.42 -5.99 -0.31 5.53e-9 Reticulocyte count; LUSC cis rs6500602 0.893 rs4786490 chr16:4491190 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.49 -6.59 -0.34 1.68e-10 Schizophrenia; LUSC trans rs225245 0.755 rs226432 chr17:34043825 G/A cg19694781 chr19:47549865 TMEM160 0.4 6.3 0.33 9.54e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7829975 0.514 rs2976926 chr8:8261624 T/C cg21775007 chr8:11205619 TDH 0.41 6.09 0.32 3.12e-9 Mood instability; LUSC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg11247378 chr22:39784982 NA -0.62 -11.18 -0.52 7.53e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs77106637 1.000 rs3862791 chr11:72501002 C/T cg03713592 chr11:72463424 ARAP1 0.83 9.68 0.47 1.1e-19 Type 2 diabetes; LUSC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg20476274 chr7:133979776 SLC35B4 0.87 17.01 0.68 3.4e-47 Mean platelet volume; LUSC cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC trans rs12579753 1.000 rs10862374 chr12:82250809 G/C cg07923666 chr12:49932857 KCNH3 -0.52 -6.42 -0.33 4.79e-10 Resting heart rate; LUSC cis rs2901656 0.640 rs9425316 chr1:172400860 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.37 7.71 0.39 1.42e-13 Red cell distribution width;Platelet distribution width; LUSC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg12311346 chr5:56204834 C5orf35 -0.62 -8.84 -0.44 5.69e-17 Coronary artery disease; LUSC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg08975724 chr8:8085496 FLJ10661 -0.45 -6.42 -0.33 4.69e-10 Joint mobility (Beighton score); LUSC trans rs12546962 0.705 rs17149279 chr8:9195638 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.05 0.31 3.86e-9 Body mass index; LUSC cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg06092702 chr1:163392909 NA -0.45 -7.36 -0.37 1.4e-12 Motion sickness; LUSC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg03433033 chr1:76189801 ACADM 0.75 11.6 0.54 2.29e-26 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3737883 1.000 rs7538696 chr1:203034309 G/A cg00805880 chr1:203045044 PPFIA4 -0.29 -5.76 -0.3 1.95e-8 Early onset atrial fibrillation; LUSC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg06022373 chr22:39101656 GTPBP1 0.85 14.17 0.61 5.06e-36 Menopause (age at onset); LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg08859206 chr1:53392774 SCP2 -0.54 -9.57 -0.46 2.44e-19 Monocyte count; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.97 -0.51 4.1e-24 Body mass index; LUSC cis rs12618769 0.597 rs6753515 chr2:99128965 T/A cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs1577917 0.958 rs6921315 chr6:86471668 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.53 -0.42 5.22e-16 Response to antipsychotic treatment; LUSC cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg07157834 chr1:205819609 PM20D1 0.95 19.47 0.73 5.96e-57 Menarche (age at onset); LUSC cis rs722599 0.715 rs2080086 chr14:75338408 G/A cg06637938 chr14:75390232 RPS6KL1 -0.4 -5.9 -0.31 9.01e-9 IgG glycosylation; LUSC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg16624210 chr5:671434 TPPP 0.5 6.38 0.33 6.07e-10 Obesity-related traits; LUSC cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg17892150 chr10:133769511 PPP2R2D 0.59 8.59 0.43 3.32e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs17854409 1.000 rs17854409 chr20:61491494 T/C cg05147244 chr20:61493195 TCFL5 0.96 7.01 0.36 1.31e-11 Obesity-related traits; LUSC cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg01256987 chr12:42539512 GXYLT1 -0.45 -8.45 -0.42 9.42e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs57920188 0.703 rs3813810 chr1:4088339 G/T cg20703997 chr1:4087676 NA 0.56 8.58 0.42 3.73e-16 Interleukin-17 levels; LUSC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 0.867 rs4075674 chr15:43650230 A/C cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.38 0.59 5.5e-33 Platelet count; LUSC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg11645453 chr3:52864694 ITIH4 0.32 7.53 0.38 4.64e-13 Bipolar disorder; LUSC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.51 7.81 0.39 7.49e-14 Eosinophil percentage of white cells; LUSC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.38 -6.18 -0.32 1.89e-9 Alzheimer's disease (late onset); LUSC cis rs721399 0.539 rs10103148 chr8:18267429 A/C cg18736775 chr8:18248649 NAT2 -0.6 -7.09 -0.36 7.9e-12 Blood metabolite levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20409466 chr11:9635889 NA -0.44 -6.56 -0.34 2.02e-10 Hepatitis; LUSC trans rs9388451 0.903 rs7758115 chr6:126061502 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.58 -9.48 -0.46 4.85e-19 Brugada syndrome; LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.02 -0.31 4.58e-9 Platelet count; LUSC cis rs34779708 0.966 rs10827492 chr10:35429825 A/G cg04310649 chr10:35416472 CREM 0.42 6.53 0.34 2.43e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg04455712 chr21:45112962 RRP1B -0.47 -8.86 -0.44 4.92e-17 Mean corpuscular volume; LUSC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg20307385 chr11:47447363 PSMC3 0.45 5.82 0.3 1.37e-8 Subjective well-being; LUSC cis rs477692 0.517 rs871026 chr10:131293145 A/G cg11019008 chr10:131425282 MGMT -0.39 -5.78 -0.3 1.69e-8 Response to temozolomide; LUSC trans rs6427356 1.000 rs1176555 chr1:157136541 C/G cg09396181 chr3:13921839 WNT7A 0.39 6.28 0.32 1.05e-9 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs9527 0.590 rs7088200 chr10:104793235 G/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.35 -0.33 6.93e-10 Arsenic metabolism; LUSC cis rs12701220 0.842 rs10236293 chr7:1032637 G/A cg26769984 chr7:1090371 C7orf50 0.66 8.67 0.43 1.85e-16 Bronchopulmonary dysplasia; LUSC cis rs9527 0.830 rs11191440 chr10:104641511 G/A cg04362960 chr10:104952993 NT5C2 0.65 9.41 0.46 8.54e-19 Arsenic metabolism; LUSC cis rs273573 0.961 rs175399 chr11:30930374 A/C cg06552810 chr11:31128660 NA 0.32 5.69 0.3 2.78e-8 Total body bone mineral density; LUSC cis rs4478858 0.684 rs16834336 chr1:31751512 G/A cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs11190604 1.000 rs10883497 chr10:102228519 A/G cg07080220 chr10:102295463 HIF1AN 0.63 8.55 0.42 4.63e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg00071950 chr4:10020882 SLC2A9 0.64 10.93 0.51 5.65e-24 Bone mineral density; LUSC cis rs7091068 1.000 rs7091068 chr10:95420385 G/T cg20715218 chr10:95462985 C10orf4 0.58 6.09 0.32 3.06e-9 Urinary tract infection frequency; LUSC cis rs7712401 0.601 rs246321 chr5:122308299 A/G cg19077854 chr5:122220652 SNX24 0.43 9.65 0.47 1.39e-19 Mean platelet volume; LUSC cis rs11190604 1.000 rs4919469 chr10:102298855 C/A cg07080220 chr10:102295463 HIF1AN 0.69 9.38 0.46 1.06e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg21433313 chr16:3507492 NAT15 0.41 5.88 0.31 1e-8 Body mass index (adult); LUSC cis rs9463078 0.683 rs227855 chr6:44702352 T/C cg25276700 chr6:44698697 NA 0.31 6.25 0.32 1.22e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg03676636 chr4:99064102 C4orf37 0.29 6.19 0.32 1.74e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC trans rs12310956 0.515 rs1852221 chr12:33945489 G/T cg13010199 chr12:38710504 ALG10B 0.54 8.05 0.4 1.46e-14 Morning vs. evening chronotype; LUSC cis rs10782582 0.569 rs4549990 chr1:76125075 A/G cg03433033 chr1:76189801 ACADM -0.45 -6.84 -0.35 3.86e-11 Daytime sleep phenotypes; LUSC cis rs9660992 0.674 rs17345816 chr1:205262868 A/T cg21545522 chr1:205238299 TMCC2 -0.49 -9.34 -0.46 1.37e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs926938 0.563 rs360645 chr1:115427218 A/G cg12756093 chr1:115239321 AMPD1 0.39 5.77 0.3 1.81e-8 Autism; LUSC cis rs56399783 0.901 rs17132741 chr7:2868997 C/T cg14895029 chr7:2775587 GNA12 -0.46 -6.07 -0.32 3.56e-9 Childhood ear infection; LUSC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg06634786 chr22:41940651 POLR3H -0.6 -6.81 -0.35 4.48e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg19678392 chr7:94953810 PON1 -0.36 -5.91 -0.31 8.37e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg15105969 chr2:36825350 FEZ2 -0.42 -5.86 -0.31 1.14e-8 Height; LUSC cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14240646 chr10:27532245 ACBD5 -0.72 -9.52 -0.46 3.66e-19 Breast cancer; LUSC cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg08807101 chr21:30365312 RNF160 0.71 11.42 0.53 1.04e-25 Pancreatic cancer; LUSC cis rs7772486 0.654 rs4896829 chr6:145953675 T/A cg05347473 chr6:146136440 FBXO30 0.41 6.82 0.35 4.18e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs17253792 0.822 rs8009239 chr14:56062490 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs642803 0.613 rs565427 chr11:65532825 G/A cg27068330 chr11:65405492 SIPA1 0.55 7.58 0.38 3.37e-13 Urate levels; LUSC cis rs1371867 0.846 rs1788194 chr8:101277916 T/C cg06002616 chr8:101225028 SPAG1 -0.44 -7.3 -0.37 2.18e-12 Atrioventricular conduction; LUSC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg02574844 chr11:5959923 NA -0.42 -6.06 -0.31 3.65e-9 DNA methylation (variation); LUSC cis rs7582180 0.700 rs2309852 chr2:100982527 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.61 -0.43 2.87e-16 Intelligence (multi-trait analysis); LUSC cis rs983392 0.679 rs672399 chr11:60020112 T/G cg20284999 chr11:59952153 MS4A6A 0.39 6.45 0.33 3.93e-10 Alzheimer's disease (late onset); LUSC cis rs926938 0.563 rs360635 chr1:115420518 A/C cg12756093 chr1:115239321 AMPD1 0.45 6.57 0.34 1.98e-10 Autism; LUSC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg07701084 chr6:150067640 NUP43 0.57 8.88 0.44 4.29e-17 Lung cancer; LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg23758822 chr17:41437982 NA 1.02 19.72 0.73 5.91e-58 Menopause (age at onset); LUSC cis rs500891 0.525 rs1145898 chr6:84039566 T/C cg08257003 chr6:84140564 ME1 0.34 8.2 0.41 5.18e-15 Platelet-derived growth factor BB levels; LUSC trans rs874040 0.962 rs7673206 chr4:26126838 C/T cg09985802 chr10:126234119 LHPP -0.29 -5.95 -0.31 6.93e-9 Rheumatoid arthritis; LUSC cis rs2387326 0.717 rs10829338 chr10:129943625 C/T cg16087940 chr10:129947807 NA -0.39 -5.78 -0.3 1.7e-8 Select biomarker traits; LUSC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg14784868 chr12:69753453 YEATS4 0.55 8.39 0.42 1.41e-15 Response to diuretic therapy; LUSC cis rs7568458 0.870 rs6757263 chr2:85803542 A/G cg17127132 chr2:85788382 GGCX 0.49 7.93 0.4 3.4e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs7824557 0.591 rs2736282 chr8:11225480 C/T cg06636001 chr8:8085503 FLJ10661 0.5 7.56 0.38 3.88e-13 Retinal vascular caliber; LUSC cis rs3849570 0.615 rs9817070 chr3:81982936 A/G cg07356753 chr3:81810745 GBE1 -0.44 -6.47 -0.33 3.56e-10 Waist circumference;Body mass index; LUSC cis rs4363385 0.818 rs532773 chr1:153011750 T/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg18681998 chr4:17616180 MED28 0.92 17.41 0.69 9.18e-49 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs568617 0.716 rs17854357 chr11:65601560 G/C cg19792802 chr11:65647270 CTSW 0.47 6.45 0.33 4e-10 Crohn's disease; LUSC cis rs3540 0.533 rs2352601 chr15:91053125 G/A cg22089800 chr15:90895588 ZNF774 -0.62 -9.34 -0.46 1.39e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs67981189 0.634 rs221896 chr14:71606668 C/G cg15816911 chr14:71606274 NA -0.35 -6.13 -0.32 2.49e-9 Schizophrenia; LUSC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg05623727 chr3:50126028 RBM5 -0.35 -6.66 -0.34 1.1e-10 Body mass index; LUSC cis rs4834770 0.792 rs6823331 chr4:120180790 T/C cg24375607 chr4:120327624 NA 0.42 5.82 0.3 1.39e-8 Blood protein levels; LUSC cis rs1448094 0.802 rs12369634 chr12:86406792 C/G cg00310523 chr12:86230176 RASSF9 0.36 6.57 0.34 1.98e-10 Major depressive disorder; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg08219700 chr8:58056026 NA 0.66 7.82 0.39 7.08e-14 Developmental language disorder (linguistic errors); LUSC cis rs4423214 1.000 rs7928249 chr11:71161063 A/G cg05163923 chr11:71159392 DHCR7 0.76 10.91 0.51 6.73e-24 Vitamin D levels; LUSC trans rs7824557 0.564 rs35009431 chr8:11232788 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -8.61 -0.43 3.01e-16 Retinal vascular caliber; LUSC cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg23750338 chr8:142222470 SLC45A4 -0.57 -11.29 -0.53 2.84e-25 Immature fraction of reticulocytes; LUSC cis rs4076764 0.846 rs4255362 chr1:163424630 G/A cg06092702 chr1:163392909 NA -0.42 -7.14 -0.36 5.95e-12 Motion sickness; LUSC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11890956 chr21:40555474 PSMG1 -0.94 -16.94 -0.68 6.62e-47 Cognitive function; LUSC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg24399712 chr22:39784796 NA -0.64 -11.51 -0.53 4.76e-26 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.508 rs1594437 chr8:8825875 T/C cg15556689 chr8:8085844 FLJ10661 0.56 9.01 0.44 1.57e-17 Mood instability; LUSC cis rs12042107 0.818 rs12046000 chr1:91192396 G/T cg13456504 chr1:91191583 NA 0.42 7.07 0.36 8.9e-12 Educational attainment; LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg08048268 chr3:133502702 NA -0.44 -8.65 -0.43 2.25e-16 Iron status biomarkers; LUSC cis rs1953600 0.870 rs2236557 chr10:81923961 A/G cg04850286 chr10:81895943 PLAC9 0.33 5.74 0.3 2.13e-8 Sarcoidosis; LUSC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.49 7.56 0.38 3.98e-13 Eosinophil percentage of white cells; LUSC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg26314531 chr2:26401878 FAM59B -0.68 -9.32 -0.45 1.67e-18 Gut microbiome composition (summer); LUSC cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg02503808 chr4:7069936 GRPEL1 1.02 14.02 0.61 1.87e-35 Monocyte percentage of white cells; LUSC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg18351406 chr4:77819688 ANKRD56 0.44 6.11 0.32 2.85e-9 Emphysema distribution in smoking; LUSC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg15212455 chr7:39170539 POU6F2 0.59 10.21 0.49 1.71e-21 IgG glycosylation; LUSC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.47 6.98 0.36 1.62e-11 Schizophrenia; LUSC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.25 -0.32 1.23e-9 Breast cancer; LUSC cis rs782590 0.748 rs782634 chr2:55897700 T/C cg18811423 chr2:55921094 PNPT1 0.78 13.07 0.58 8.16e-32 Metabolic syndrome; LUSC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg18904891 chr8:8559673 CLDN23 -0.38 -5.72 -0.3 2.39e-8 Mood instability; LUSC trans rs3733585 0.699 rs7663097 chr4:9966791 T/C cg26043149 chr18:55253948 FECH -0.46 -7.1 -0.36 7.46e-12 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23501767 chr5:133340570 VDAC1 -0.43 -6.41 -0.33 4.89e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs259282 0.605 rs3760937 chr19:33106893 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.64 9.64 0.47 1.49e-19 Schizophrenia; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg11494091 chr17:61959527 GH2 0.7 14.78 0.63 2.12e-38 Prudent dietary pattern; LUSC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs9902453 0.765 rs34585141 chr17:28336432 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.42 -0.5 3.27e-22 Coffee consumption (cups per day); LUSC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg18876405 chr7:65276391 NA 0.68 12.02 0.55 6.86e-28 Aortic root size; LUSC cis rs72901758 0.661 rs56683270 chr17:76247827 T/C cg25512537 chr17:76250053 NA 0.41 7.58 0.38 3.51e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs9650657 0.504 rs10108347 chr8:11033517 G/C cg15556689 chr8:8085844 FLJ10661 -0.57 -8.56 -0.42 4.06e-16 Neuroticism; LUSC cis rs453301 0.653 rs2956244 chr8:8885166 A/G cg15556689 chr8:8085844 FLJ10661 0.69 11.21 0.52 5.75e-25 Joint mobility (Beighton score); LUSC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg04166393 chr7:2884313 GNA12 0.41 5.71 0.3 2.48e-8 Height; LUSC cis rs6545883 0.894 rs2694632 chr2:61558682 T/C cg15711740 chr2:61764176 XPO1 0.42 6.52 0.34 2.6200000000000003e-10 Tuberculosis; LUSC trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs11690935 1.000 rs34542126 chr2:172542705 C/T cg13550731 chr2:172543902 DYNC1I2 0.89 14.86 0.63 1.04e-38 Schizophrenia; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg11060661 chr22:24314208 DDT;DDTL -0.44 -6.91 -0.35 2.46e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.72 -6.72 -0.35 7.85e-11 Cerebrospinal P-tau181p levels; LUSC cis rs17604090 0.715 rs73088359 chr7:29647678 T/C cg19413766 chr7:29689036 LOC646762 -0.5 -5.99 -0.31 5.31e-9 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg06713675 chr4:122721982 EXOSC9 -0.66 -11.42 -0.53 1.02e-25 Type 2 diabetes; LUSC cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.99 0.55 8.55e-28 Chronic sinus infection; LUSC cis rs3741151 0.773 rs6592526 chr11:73208911 C/T cg17517138 chr11:73019481 ARHGEF17 0.96 8.24 0.41 3.97e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2602836 0.830 rs2602874 chr4:100039396 A/T cg12011299 chr4:100065546 ADH4 0.72 13.59 0.6 8.89e-34 HDL cholesterol;HDL cholesterol levels; LUSC cis rs66887589 0.967 rs7678973 chr4:120511817 T/C cg09307838 chr4:120376055 NA -0.47 -7.23 -0.37 3.42e-12 Diastolic blood pressure; LUSC cis rs703842 0.616 rs871871 chr12:58219681 G/A cg00677455 chr12:58241039 CTDSP2 0.69 10.34 0.49 6.09e-22 Multiple sclerosis; LUSC cis rs6696846 0.777 rs9651228 chr1:205049383 A/G cg03948781 chr1:205179583 DSTYK 0.29 5.74 0.3 2.14e-8 Red blood cell count; LUSC cis rs3771570 1.000 rs6752050 chr2:242228780 T/C cg21155796 chr2:242212141 HDLBP 0.65 7.14 0.36 5.86e-12 Prostate cancer; LUSC cis rs2274273 0.905 rs17128183 chr14:55579513 C/T cg04306507 chr14:55594613 LGALS3 -0.55 -12.64 -0.57 3.33e-30 Protein biomarker; LUSC cis rs897080 0.552 rs1067369 chr2:44652654 A/T cg00619915 chr2:44497795 NA -0.42 -6.08 -0.32 3.24e-9 Height; LUSC cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.14 -0.41 7.94e-15 Axial length; LUSC cis rs62408225 1.000 rs17513531 chr6:90951239 C/T cg06866423 chr6:90926672 BACH2 0.4 5.74 0.3 2.16e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs600231 0.706 rs4244811 chr11:65320780 G/A cg17120908 chr11:65337727 SSSCA1 0.58 9.6 0.47 1.93e-19 Bone mineral density; LUSC trans rs877282 0.945 rs71491311 chr10:791747 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs11677416 1.000 rs1878321 chr2:113544434 A/G cg27083787 chr2:113543245 IL1A 0.45 7.13 0.36 6.29e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.05 -0.31 3.85e-9 Intelligence (multi-trait analysis); LUSC cis rs734999 0.588 rs4648653 chr1:2535895 C/T cg18932078 chr1:2524107 MMEL1 0.32 6.98 0.36 1.58e-11 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05887047 chr13:114270659 TFDP1 -0.41 -6.01 -0.31 4.99e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg24812749 chr6:127587940 RNF146 0.62 9.16 0.45 5.54e-18 Breast cancer; LUSC cis rs1018836 0.663 rs3950221 chr8:91478108 G/A cg16814680 chr8:91681699 NA -0.67 -10.38 -0.49 4.59e-22 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs977987 0.843 rs59155720 chr16:75483806 A/G cg04384234 chr16:75411784 CFDP1 -0.43 -7.15 -0.36 5.35e-12 Dupuytren's disease; LUSC cis rs939574 1.000 rs939574 chr2:220118531 G/C cg00496455 chr2:220118770 TUBA4A;TUBA4B -1.02 -8.86 -0.44 4.81e-17 Platelet distribution width; LUSC cis rs6545883 0.931 rs9807965 chr2:61732159 T/C cg15711740 chr2:61764176 XPO1 -0.48 -7.46 -0.38 7.69e-13 Tuberculosis; LUSC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.57 -0.34 1.99e-10 Schizophrenia; LUSC trans rs61931739 0.749 rs7315233 chr12:34271975 G/T cg24313572 chr1:56050060 NA -0.3 -6.32 -0.33 8.52e-10 Morning vs. evening chronotype; LUSC cis rs7941600 0.786 rs7925418 chr11:9197500 T/C cg19415743 chr11:9336845 TMEM41B 0.59 5.91 0.31 8.62e-9 Coronary artery disease; LUSC trans rs750134 0.901 rs17040895 chr12:109093713 C/T cg23338993 chr2:234600423 UGT1A10;UGT1A6;UGT1A9;UGT1A7;UGT1A8 0.5 6.13 0.32 2.47e-9 Low high density lipoprotein cholesterol levels; LUSC cis rs4925114 0.568 rs941448 chr17:17654542 C/G cg09796270 chr17:17721594 SREBF1 -0.43 -7.32 -0.37 1.87e-12 Body mass index; LUSC cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg15744005 chr10:104629667 AS3MT -0.28 -6.02 -0.31 4.53e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg23711669 chr6:146136114 FBXO30 0.77 13.91 0.61 5.36e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs6460942 0.730 rs7780477 chr7:12233750 G/C cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg21535247 chr6:8435926 SLC35B3 0.57 9.0 0.44 1.69e-17 Motion sickness; LUSC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg03609598 chr5:56110824 MAP3K1 -0.41 -6.1 -0.32 2.85e-9 Initial pursuit acceleration; LUSC cis rs4595586 0.545 rs4768505 chr12:39380338 C/A cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg13877915 chr19:58951672 ZNF132 0.49 7.73 0.39 1.26e-13 Uric acid clearance; LUSC cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg15813090 chr5:442598 EXOC3;C5orf55 -0.35 -5.68 -0.3 3e-8 Cystic fibrosis severity; LUSC cis rs34311866 0.808 rs11248059 chr4:960331 C/G cg14530993 chr4:882597 GAK 0.71 7.06 0.36 9.85e-12 Parkinson's disease; LUSC trans rs11098499 0.818 rs10008791 chr4:120431469 A/C cg25214090 chr10:38739885 LOC399744 0.5 7.39 0.37 1.19e-12 Corneal astigmatism; LUSC cis rs2742234 0.590 rs2435376 chr10:43684963 A/G cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg24531977 chr5:56204891 C5orf35 0.98 14.69 0.63 5.01e-38 Initial pursuit acceleration; LUSC cis rs9902453 0.817 rs62068620 chr17:28167674 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.34 0.46 1.36e-18 Coffee consumption (cups per day); LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.76 0.47 5.92e-20 Bipolar disorder; LUSC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg11247378 chr22:39784982 NA -0.65 -12.86 -0.58 5.13e-31 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg23711669 chr6:146136114 FBXO30 0.88 16.37 0.67 1.21e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg02038168 chr22:39784481 NA -0.5 -8.25 -0.41 3.72e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.17e-9 Blood metabolite levels; LUSC cis rs12681287 0.609 rs13281414 chr8:87495254 A/C cg00550725 chr8:87521180 FAM82B 0.45 5.87 0.31 1.07e-8 Caudate activity during reward; LUSC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg09455208 chr3:40491958 NA 0.57 10.33 0.49 6.86e-22 Renal cell carcinoma; LUSC trans rs8002861 0.935 rs9525865 chr13:44459647 A/T cg12856521 chr11:46389249 DGKZ 0.4 6.35 0.33 7.17e-10 Leprosy; LUSC cis rs11997175 0.766 rs4273817 chr8:33702686 C/T ch.8.33884649F chr8:33765107 NA 0.37 5.8 0.3 1.5e-8 Body mass index; LUSC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.58 -0.46 2.35e-19 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21062897 chr14:50999680 MAP4K5;ATL1 -0.52 -6.89 -0.35 2.79e-11 Bipolar disorder and schizophrenia; LUSC cis rs6961069 0.658 rs7806711 chr7:80217290 T/G cg04458919 chr7:80252533 CD36 -0.4 -7.0 -0.36 1.41e-11 Platelet count; LUSC cis rs561341 0.739 rs4795663 chr17:30214542 T/C cg13647721 chr17:30228624 UTP6 -0.7 -9.28 -0.45 2.26e-18 Hip circumference adjusted for BMI; LUSC cis rs6500602 0.702 rs2270366 chr16:4558615 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.48 -6.54 -0.34 2.3e-10 Schizophrenia; LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg08470875 chr2:26401718 FAM59B -0.69 -9.37 -0.46 1.16e-18 Gut microbiome composition (summer); LUSC cis rs7538876 1.000 rs4920603 chr1:17727379 C/G cg07965774 chr1:17746286 RCC2 -0.3 -5.75 -0.3 2.02e-8 Basal cell carcinoma; LUSC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg26597838 chr10:835615 NA -0.94 -13.95 -0.61 3.67e-35 Eosinophil percentage of granulocytes; LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg10802521 chr3:52805072 NEK4 -0.58 -9.1 -0.45 8.23e-18 Bipolar disorder; LUSC cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg17264618 chr3:40429014 ENTPD3 -0.31 -6.54 -0.34 2.26e-10 Renal cell carcinoma; LUSC cis rs12620999 1.000 rs4558538 chr2:238055975 C/T cg23555395 chr2:238036564 NA -0.51 -8.74 -0.43 1.18e-16 Systemic lupus erythematosus; LUSC cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg05868516 chr6:26286170 HIST1H4H -0.35 -5.78 -0.3 1.76e-8 Educational attainment; LUSC cis rs5167 0.601 rs892131 chr19:45496996 C/T cg25746394 chr19:45450501 APOC2 0.31 5.77 0.3 1.83e-8 Blood protein levels; LUSC cis rs11955175 1.000 rs11953942 chr5:40674713 C/A cg05478818 chr5:40835740 RPL37 0.7 5.77 0.3 1.81e-8 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9815354 0.812 rs73071203 chr3:41977464 A/C cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs8114671 0.836 rs2425006 chr20:33571228 T/G cg24642439 chr20:33292090 TP53INP2 -0.42 -6.04 -0.31 4.2e-9 Height; LUSC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg26314531 chr2:26401878 FAM59B -0.69 -9.39 -0.46 9.76e-19 Gut microbiome composition (summer); LUSC cis rs9640161 0.750 rs3735169 chr7:150034378 A/G cg17279839 chr7:150038598 RARRES2 0.54 8.14 0.41 7.95e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs11051970 0.879 rs950079 chr12:32588620 A/G cg02745156 chr12:32552066 NA 0.43 7.29 0.37 2.29e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4919694 1.000 rs4919694 chr10:104698978 T/C cg04362960 chr10:104952993 NT5C2 1.1 13.31 0.59 9.96e-33 Arsenic metabolism; LUSC trans rs57046232 0.552 rs2009127 chr20:6341680 C/T cg21095983 chr6:86352623 SYNCRIP 0.48 7.14 0.36 5.84e-12 Colorectal cancer; LUSC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg24324837 chr19:49891574 CCDC155 0.56 7.72 0.39 1.41e-13 Multiple sclerosis; LUSC cis rs9341808 0.587 rs3805859 chr6:81048946 C/A cg08355045 chr6:80787529 NA 0.46 8.03 0.4 1.72e-14 Sitting height ratio; LUSC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg24531977 chr5:56204891 C5orf35 -0.6 -9.11 -0.45 7.84e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg04166393 chr7:2884313 GNA12 0.42 5.75 0.3 2.06e-8 Height; LUSC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg12923728 chr3:195709715 SDHAP1 0.78 12.18 0.55 1.69e-28 Pancreatic cancer; LUSC cis rs7481584 0.669 rs12421922 chr11:3035070 A/G cg08508325 chr11:3079039 CARS 0.35 7.76 0.39 1.03e-13 Calcium levels; LUSC cis rs10761482 0.861 rs10761484 chr10:62098458 T/C cg18175470 chr10:62150864 ANK3 -0.5 -7.06 -0.36 9.52e-12 Schizophrenia; LUSC cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs11190604 1.000 rs11190595 chr10:102291761 T/C cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12421382 0.659 rs1439511 chr11:109392839 G/T cg11473876 chr11:109292803 C11orf87 -0.45 -6.82 -0.35 4.18e-11 Schizophrenia; LUSC cis rs5167 0.566 rs60876330 chr19:45488133 C/T cg25746394 chr19:45450501 APOC2 0.32 6.07 0.32 3.55e-9 Blood protein levels; LUSC cis rs4938330 0.681 rs12271169 chr11:116980021 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.86 -0.35 3.42e-11 Blood protein levels; LUSC cis rs72781680 0.950 rs56128748 chr2:24126809 T/G cg08917208 chr2:24149416 ATAD2B 0.89 10.1 0.48 4.26e-21 Lymphocyte counts; LUSC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg17554472 chr22:41940697 POLR3H -0.5 -5.89 -0.31 9.24e-9 Vitiligo; LUSC cis rs981844 0.683 rs2405423 chr4:154749823 C/A cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg15704280 chr7:45808275 SEPT13 -1.1 -21.59 -0.76 2.55e-65 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02158565 chr7:150788256 AGAP3 -0.35 -5.96 -0.31 6.48e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6558174 0.965 rs6558172 chr8:22492052 C/T cg03733263 chr8:22462867 KIAA1967 0.49 6.52 0.34 2.63e-10 Breast cancer; LUSC cis rs7829975 0.774 rs1039915 chr8:8679614 T/C cg08975724 chr8:8085496 FLJ10661 0.52 7.7 0.39 1.53e-13 Mood instability; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs6582630 0.638 rs35864536 chr12:38472255 T/A cg26384229 chr12:38710491 ALG10B -0.54 -8.15 -0.41 7.3e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs5758659 0.652 rs133336 chr22:42416303 C/T cg04733989 chr22:42467013 NAGA 0.39 6.58 0.34 1.85e-10 Cognitive function; LUSC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21738971 chr2:106810986 UXS1 -0.43 -6.2 -0.32 1.67e-9 Electrocardiographic conduction measures; LUSC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg14298792 chr15:30685198 CHRFAM7A 0.47 5.99 0.31 5.5e-9 Huntington's disease progression; LUSC cis rs1113500 0.933 rs10494089 chr1:108626695 T/G cg06207961 chr1:108661230 NA 0.4 7.45 0.38 8.2e-13 Growth-regulated protein alpha levels; LUSC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.44 -0.33 4.08e-10 Alzheimer's disease (late onset); LUSC cis rs28655083 0.509 rs679263 chr16:77103829 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 7.04 0.36 1.12e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg21782813 chr7:2030301 MAD1L1 0.41 6.84 0.35 3.8e-11 Bipolar disorder and schizophrenia; LUSC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg00409905 chr10:38381863 ZNF37A 0.4 6.83 0.35 4.09e-11 Extrinsic epigenetic age acceleration; LUSC cis rs12908161 0.959 rs34028043 chr15:85231585 G/A cg12863693 chr15:85201151 NMB 0.42 8.65 0.43 2.14e-16 Schizophrenia; LUSC cis rs12620999 1.000 rs28727919 chr2:238003313 C/T cg23555395 chr2:238036564 NA 0.53 8.83 0.43 6.22e-17 Systemic lupus erythematosus; LUSC cis rs2439831 0.850 rs2439832 chr15:43779686 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.02 0.52 2.75e-24 Lung cancer in ever smokers; LUSC cis rs9815354 0.904 rs73073235 chr3:42012693 C/A cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.5e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg08355456 chr11:67383691 NA 0.36 6.79 0.35 5.1e-11 Mean corpuscular volume; LUSC trans rs2587949 0.615 rs1444059 chr3:4228369 C/G cg15139668 chr4:4577005 NA -0.41 -6.1 -0.32 2.88e-9 Periodontitis (DPAL); LUSC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg02931644 chr1:25747376 RHCE -0.34 -6.2 -0.32 1.64e-9 Erythrocyte sedimentation rate; LUSC cis rs4919694 1.000 rs12245343 chr10:104774050 A/G cg23093090 chr10:104574429 C10orf26 -0.48 -5.8 -0.3 1.53e-8 Arsenic metabolism; LUSC cis rs75229567 0.618 rs75389984 chr12:70212879 A/G cg10114359 chr12:70132523 RAB3IP 1.4 12.47 0.56 1.46e-29 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs1395 0.744 rs62130709 chr2:27505782 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 6.16 0.32 2.1e-9 Blood metabolite levels; LUSC trans rs453301 0.592 rs4841084 chr8:8883905 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.13 0.32 2.51e-9 Joint mobility (Beighton score); LUSC cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg13010199 chr12:38710504 ALG10B 0.65 10.07 0.48 5.45e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs11676348 0.808 rs4674267 chr2:219046437 C/T cg23569941 chr2:219139048 TMBIM1;PNKD 0.37 5.95 0.31 6.87e-9 Ulcerative colitis; LUSC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.42 0.38 9.54e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1348850 0.750 rs13031008 chr2:178477114 G/A cg22681709 chr2:178499509 PDE11A -0.57 -10.56 -0.5 1.11e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7945705 0.870 rs1109305 chr11:8955272 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.66 14.68 0.63 5.4e-38 Hemoglobin concentration; LUSC cis rs459482 1.000 rs459498 chr21:42795027 G/A cg14166395 chr21:42792516 MX1 0.58 8.36 0.42 1.68e-15 IgG glycosylation; LUSC trans rs656319 0.564 rs11776035 chr8:10071527 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.06 -0.31 3.59e-9 Myopia (pathological); LUSC cis rs1461503 0.966 rs7944630 chr11:122838844 G/A cg27398637 chr11:122830231 C11orf63 -0.4 -6.37 -0.33 6.12e-10 Menarche (age at onset); LUSC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg23649088 chr2:200775458 C2orf69 0.55 7.44 0.38 8.44e-13 Schizophrenia; LUSC cis rs2439831 0.681 rs825740 chr15:43592408 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.31 0.53 2.5e-25 Lung cancer in ever smokers; LUSC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg01097406 chr16:89675127 NA -0.34 -6.73 -0.35 7.48e-11 Vitiligo; LUSC cis rs4845459 0.967 rs4845450 chr1:152591200 T/C cg08895932 chr1:152778580 LCE1C -0.36 -6.3 -0.33 9.62e-10 Psoriasis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00057317 chr8:11725492 CTSB -0.47 -6.25 -0.32 1.26e-9 Hepatitis; LUSC cis rs9733 0.744 rs3754211 chr1:150951857 G/A cg13175981 chr1:150552382 MCL1 -0.4 -5.64 -0.3 3.55e-8 Tonsillectomy; LUSC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg11764359 chr7:65958608 NA -0.63 -9.55 -0.46 2.94e-19 Aortic root size; LUSC cis rs4285028 0.948 rs6790281 chr3:121665543 C/A cg11130432 chr3:121712080 ILDR1 -0.64 -9.83 -0.47 3.38e-20 Multiple sclerosis; LUSC trans rs9910292 0.591 rs8081966 chr17:31358333 T/C cg03789507 chr8:136667083 NA 0.48 6.13 0.32 2.44e-9 Mosquito bite size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20127549 chr11:118868876 CCDC84 0.44 6.18 0.32 1.91e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.76 0.3 1.92e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11785400 0.762 rs4401833 chr8:143739731 A/T cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg09033563 chr22:24373618 LOC391322 0.66 10.18 0.49 2.25e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.84 -0.44 5.49e-17 Monocyte percentage of white cells; LUSC cis rs6736093 0.966 rs11685190 chr2:112748704 T/C cg12686935 chr2:112915763 FBLN7 -0.37 -6.03 -0.31 4.39e-9 Coronary artery disease; LUSC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.19 -0.32 1.79e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2282802 0.685 rs13177186 chr5:139640476 A/G cg26211634 chr5:139558579 C5orf32 0.44 8.3 0.41 2.59e-15 Intelligence (multi-trait analysis); LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg11843238 chr5:131593191 PDLIM4 0.39 7.18 0.37 4.69e-12 Blood metabolite levels; LUSC cis rs12368653 0.583 rs7952989 chr12:58095989 T/C cg15848620 chr12:58087721 OS9 -0.41 -5.85 -0.3 1.2e-8 Multiple sclerosis; LUSC cis rs709400 1.000 rs2403205 chr14:104143385 C/T cg24130564 chr14:104152367 KLC1 -0.54 -7.86 -0.4 5.23e-14 Body mass index; LUSC cis rs7647973 0.769 rs6772452 chr3:49040462 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.59 8.97 0.44 2.15e-17 Menarche (age at onset); LUSC cis rs7296418 0.922 rs1727293 chr12:123648032 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.9 -0.35 2.62e-11 Platelet count; LUSC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg25427524 chr10:38739819 LOC399744 -0.71 -13.26 -0.59 1.53e-32 Extrinsic epigenetic age acceleration; LUSC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.23 -0.32 1.42e-9 Developmental language disorder (linguistic errors); LUSC cis rs6960043 0.689 rs12538003 chr7:15058692 G/A cg19272540 chr7:15055459 NA 0.34 8.24 0.41 4.03e-15 Type 2 diabetes; LUSC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.87e-10 Reticulocyte fraction of red cells; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg16606324 chr3:10149918 C3orf24 0.67 9.99 0.48 9.9e-21 Alzheimer's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25187088 chr17:36714684 SRCIN1 -0.41 -6.01 -0.31 4.97e-9 Electrocardiographic conduction measures; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22273015 chr11:207531 RIC8A;BET1L -0.44 -6.43 -0.33 4.35e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1348850 0.561 rs57986285 chr2:178468663 C/T cg22681709 chr2:178499509 PDE11A -0.41 -5.97 -0.31 6.23e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg22508957 chr16:3507546 NAT15 -0.41 -5.84 -0.3 1.21e-8 Body mass index (adult); LUSC trans rs7829975 0.774 rs13259216 chr8:8673601 A/C cg27411982 chr8:10470053 RP1L1 0.44 6.94 0.36 2.08e-11 Mood instability; LUSC cis rs6087990 1.000 rs2424901 chr20:31344512 A/G cg13636640 chr20:31349939 DNMT3B 1.04 23.38 0.79 2.63e-72 Ulcerative colitis; LUSC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg12564285 chr5:131593104 PDLIM4 -0.44 -7.57 -0.38 3.6e-13 Breast cancer; LUSC cis rs7937682 1.000 rs9734135 chr11:111536190 G/A cg22437258 chr11:111473054 SIK2 0.47 6.38 0.33 6.07e-10 Primary sclerosing cholangitis; LUSC cis rs71403859 0.730 rs12922775 chr16:71584354 C/T cg08717414 chr16:71523259 ZNF19 -0.75 -8.27 -0.41 3.24e-15 Post bronchodilator FEV1; LUSC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 3.03e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs8114671 0.647 rs945959 chr20:33734905 G/C cg24642439 chr20:33292090 TP53INP2 0.4 5.74 0.3 2.08e-8 Height; LUSC cis rs7072216 0.922 rs59667296 chr10:100146313 A/T cg26618903 chr10:100175079 PYROXD2 -0.3 -5.79 -0.3 1.65e-8 Metabolite levels; LUSC cis rs965604 1.000 rs12916801 chr15:78769130 A/G cg18825076 chr15:78729989 IREB2 -0.42 -6.83 -0.35 3.99e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1044826 0.642 rs295481 chr3:139228811 C/T cg15131784 chr3:139108705 COPB2 0.39 6.34 0.33 7.33e-10 Obesity-related traits; LUSC trans rs961253 0.522 rs6085496 chr20:6315656 C/T cg17788362 chr6:86352627 SYNCRIP 0.46 6.44 0.33 4.21e-10 Colorectal cancer; LUSC trans rs9329221 0.537 rs6601415 chr8:9976805 C/A cg06636001 chr8:8085503 FLJ10661 0.47 6.96 0.36 1.83e-11 Neuroticism; LUSC cis rs41271473 0.750 rs72751931 chr1:228887129 G/T cg10167378 chr1:228756711 NA 0.54 6.65 0.34 1.18e-10 Chronic lymphocytic leukemia; LUSC cis rs1538970 0.962 rs4660849 chr1:45819872 A/G cg05343316 chr1:45956843 TESK2 -0.64 -9.1 -0.45 8.24e-18 Platelet count; LUSC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 1.000 rs10966 chr20:25282944 A/G cg08601574 chr20:25228251 PYGB 0.42 6.4 0.33 5.16e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7824557 0.564 rs2736290 chr8:11234298 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.99 -0.31 5.34e-9 Retinal vascular caliber; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg14893161 chr1:205819251 PM20D1 0.92 18.2 0.71 6.58e-52 Menarche (age at onset); LUSC cis rs4919694 1.000 rs7083328 chr10:104769268 G/A cg04362960 chr10:104952993 NT5C2 1.17 13.71 0.6 3.13e-34 Arsenic metabolism; LUSC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs3754214 0.857 rs9126 chr1:150259400 A/C cg15654264 chr1:150340011 RPRD2 -0.45 -7.3 -0.37 2.14e-12 Cerebrospinal fluid biomarker levels; LUSC trans rs7726839 0.540 rs55929359 chr5:595956 C/G cg11887960 chr12:57824829 NA 0.54 6.8 0.35 4.89e-11 Obesity-related traits; LUSC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg26380479 chr7:97908229 NA -0.27 -5.97 -0.31 6.22e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6500602 0.893 rs8061742 chr16:4489436 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 6.52 0.34 2.61e-10 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06240896 chr7:100136768 AGFG2 0.41 6.43 0.33 4.53e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1355223 0.506 rs7131229 chr11:34869328 A/G cg11058730 chr11:34937778 PDHX;APIP 0.46 6.5 0.34 2.93e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2625529 0.526 rs8032222 chr15:72479178 C/G cg16672083 chr15:72433130 SENP8 0.47 7.85 0.39 5.76e-14 Red blood cell count; LUSC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg11764359 chr7:65958608 NA 0.54 7.7 0.39 1.58e-13 Calcium levels; LUSC cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg13531842 chr10:38383804 ZNF37A -0.44 -6.77 -0.35 5.69e-11 Extrinsic epigenetic age acceleration; LUSC cis rs1997103 1.000 rs6948112 chr7:55411302 G/A cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3857067 0.806 rs1876918 chr4:95099424 G/A cg11021082 chr4:95130006 SMARCAD1 -0.33 -5.69 -0.3 2.76e-8 QT interval; LUSC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg17633681 chr16:88106987 BANP 0.51 9.54 0.46 3.05e-19 Menopause (age at onset); LUSC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg04414720 chr1:150670196 GOLPH3L 0.49 7.78 0.39 9.11e-14 Melanoma; LUSC cis rs950027 0.620 rs1617984 chr15:45622662 A/G cg21132104 chr15:45694354 SPATA5L1 0.41 5.81 0.3 1.44e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg20684491 chr1:25596433 NA 0.4 6.61 0.34 1.54e-10 Erythrocyte sedimentation rate; LUSC cis rs244293 0.729 rs2332313 chr17:53018825 T/G cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.89 -0.31 9.55e-9 Menarche (age at onset); LUSC cis rs9549260 0.755 rs9532577 chr13:41231542 A/G cg21288729 chr13:41239152 FOXO1 0.64 9.95 0.48 1.3e-20 Red blood cell count; LUSC trans rs61931739 0.553 rs68124042 chr12:34064431 C/A cg26384229 chr12:38710491 ALG10B 0.73 11.46 0.53 7.46e-26 Morning vs. evening chronotype; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg11494091 chr17:61959527 GH2 0.7 14.93 0.63 5.68e-39 Prudent dietary pattern; LUSC cis rs477692 0.685 rs534430 chr10:131398734 A/C cg26102564 chr10:131424627 MGMT 0.43 6.58 0.34 1.82e-10 Response to temozolomide; LUSC cis rs77741769 0.571 rs3861797 chr12:121255334 T/C cg02419362 chr12:121203948 SPPL3 0.45 8.49 0.42 6.8e-16 Mean corpuscular volume; LUSC cis rs9857275 0.501 rs13072100 chr3:141196647 G/A cg00789793 chr3:141329863 RASA2 0.4 5.72 0.3 2.4e-8 Prion diseases; LUSC cis rs796825 0.530 rs34998142 chr3:119939802 T/C cg21790991 chr3:120137480 FSTL1 -0.33 -5.83 -0.3 1.32e-8 HIV-1 susceptibility; LUSC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg12863693 chr15:85201151 NMB 0.34 6.82 0.35 4.26e-11 Schizophrenia; LUSC trans rs9329221 0.935 rs3750310 chr8:10283426 G/A cg06636001 chr8:8085503 FLJ10661 -0.54 -7.84 -0.39 6.07e-14 Neuroticism; LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.68 0.34 9.71e-11 Menopause (age at onset); LUSC cis rs12760731 0.623 rs7547158 chr1:178309399 A/G cg00404053 chr1:178313656 RASAL2 0.47 5.82 0.3 1.39e-8 Obesity-related traits; LUSC cis rs1348850 0.537 rs3770010 chr2:178537796 T/C cg22681709 chr2:178499509 PDE11A -0.55 -11.03 -0.52 2.5300000000000002e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3808502 0.525 rs9650661 chr8:11427133 G/T cg21775007 chr8:11205619 TDH -0.56 -7.9 -0.4 4.08e-14 Neuroticism; LUSC cis rs77106637 0.769 rs11603313 chr11:72588177 G/A cg03878208 chr11:72483293 STARD10 0.58 7.71 0.39 1.46e-13 Type 2 diabetes; LUSC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs4595586 0.545 rs2388174 chr12:39389237 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.09 0.36 8.04e-12 Morning vs. evening chronotype; LUSC cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg18477163 chr1:228402036 OBSCN -0.55 -10.03 -0.48 7.34e-21 Diastolic blood pressure; LUSC cis rs66573146 0.656 rs41410847 chr4:6957332 C/T cg00086871 chr4:6988644 TBC1D14 0.81 8.72 0.43 1.35e-16 Granulocyte percentage of myeloid white cells; LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs9388451 0.807 rs1268065 chr6:126042783 G/A cg05901451 chr6:126070800 HEY2 0.89 16.86 0.68 1.42e-46 Brugada syndrome; LUSC cis rs7107174 0.786 rs4945266 chr11:78027488 A/G cg02023728 chr11:77925099 USP35 0.48 6.83 0.35 4.04e-11 Testicular germ cell tumor; LUSC cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC cis rs40363 1.000 rs37767 chr16:3514962 C/T cg01073479 chr16:3509474 NAT15 0.39 5.65 0.3 3.46e-8 Tuberculosis; LUSC cis rs1775715 0.835 rs1419169 chr10:32257204 C/G cg26784012 chr10:32216390 ARHGAP12 0.41 6.64 0.34 1.29e-10 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7613875 0.600 rs1138536 chr3:50153356 C/T cg21659725 chr3:3221576 CRBN 0.55 8.75 0.43 1.04e-16 Body mass index; LUSC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg05347473 chr6:146136440 FBXO30 -0.48 -7.99 -0.4 2.25e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2236918 0.965 rs2488472 chr1:242019919 T/C cg17736920 chr1:242011382 EXO1 0.46 7.19 0.37 4.4e-12 Menopause (age at onset); LUSC trans rs7632427 0.901 rs35124509 chr3:89521693 A/G cg15657888 chr2:113735612 IL1F9 0.26 6.04 0.31 4.15e-9 Orofacial clefts; LUSC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg23625390 chr15:77176239 SCAPER 0.46 6.85 0.35 3.54e-11 Blood metabolite levels; LUSC cis rs4595586 0.679 rs4768473 chr12:39326256 A/G cg26384229 chr12:38710491 ALG10B 0.44 5.97 0.31 6.12e-9 Morning vs. evening chronotype; LUSC trans rs6952808 0.929 rs11768206 chr7:1932151 T/G cg04565464 chr8:145669602 NFKBIL2 0.4 6.64 0.34 1.26e-10 Bipolar disorder and schizophrenia; LUSC cis rs4478858 0.684 rs7544946 chr1:31749736 T/C cg00250761 chr1:31883323 NA -0.33 -7.95 -0.4 2.9e-14 Alcohol dependence; LUSC cis rs11168618 1.000 rs10875833 chr12:48953368 C/T cg24011408 chr12:48396354 COL2A1 0.41 6.43 0.33 4.46e-10 Adiponectin levels; LUSC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg19077165 chr18:44547161 KATNAL2 -0.38 -5.76 -0.3 1.94e-8 Personality dimensions; LUSC cis rs2235544 0.565 rs12758219 chr1:54466145 G/A cg25741118 chr1:54482237 LDLRAD1 0.28 6.03 0.31 4.41e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs10876993 0.855 rs1689604 chr12:58048304 T/C cg18357645 chr12:58087776 OS9 0.51 7.6 0.38 3.05e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.24 0.45 3.06e-18 Motion sickness; LUSC cis rs834603 0.575 rs834609 chr7:47456846 T/C cg09696706 chr7:47479511 TNS3 0.32 5.76 0.3 1.94e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg09033563 chr22:24373618 LOC391322 -0.65 -10.44 -0.5 2.96e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1551570 0.755 rs2290687 chr19:10229521 C/T cg16327482 chr19:10226339 EIF3G 0.39 7.18 0.37 4.44e-12 Narcolepsy; LUSC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg12463550 chr7:65579703 CRCP 0.51 7.52 0.38 5.19e-13 Aortic root size; LUSC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg10523679 chr1:76189770 ACADM 0.9 15.7 0.65 5.45e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2652834 0.851 rs1126310 chr15:63428765 G/A cg05507819 chr15:63340323 TPM1 0.45 5.77 0.3 1.82e-8 HDL cholesterol; LUSC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg21724239 chr8:58056113 NA 0.66 7.4 0.38 1.14e-12 Developmental language disorder (linguistic errors); LUSC cis rs3806843 0.607 rs246044 chr5:140330656 C/T cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs240110 0.515 rs12530388 chr6:101329173 A/C cg09795085 chr6:101329169 ASCC3 0.49 7.25 0.37 2.9e-12 Neuroticism; LUSC cis rs7119 0.717 rs12904212 chr15:77815833 C/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs943466 0.513 rs755497 chr6:33734419 C/T cg25922239 chr6:33757077 LEMD2 -0.4 -5.65 -0.3 3.47e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; LUSC cis rs78663649 0.708 rs79268770 chr19:16601411 A/T cg05286348 chr19:16641544 CHERP -1.34 -10.65 -0.5 5.16e-23 White blood cell count; LUSC cis rs9486719 0.948 rs11152953 chr6:96894305 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs7119 0.717 rs11629835 chr15:77787469 G/T cg05673287 chr15:77411982 SGK269 -0.44 -6.98 -0.36 1.6e-11 Type 2 diabetes; LUSC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.69e-12 Depression; LUSC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg11871910 chr12:69753446 YEATS4 0.58 7.88 0.4 4.75e-14 Response to diuretic therapy; LUSC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.18 0.37 4.63e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7923609 0.869 rs9971352 chr10:65265108 A/T cg01631684 chr10:65280961 REEP3 -0.43 -6.55 -0.34 2.24e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs977987 0.843 rs11149820 chr16:75422760 G/A cg04384234 chr16:75411784 CFDP1 -0.46 -7.65 -0.39 2.21e-13 Dupuytren's disease; LUSC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg26408565 chr15:76604113 ETFA -0.49 -7.84 -0.39 6.1e-14 Blood metabolite levels; LUSC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg00310523 chr12:86230176 RASSF9 -0.44 -8.28 -0.41 3.05e-15 Major depressive disorder; LUSC cis rs4780401 0.587 rs9931332 chr16:11807517 G/C cg01061890 chr16:11836724 TXNDC11 -0.56 -8.66 -0.43 2.01e-16 Rheumatoid arthritis; LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.82e-10 Bipolar disorder; LUSC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.9 -0.35 2.57e-11 Total body bone mineral density; LUSC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg21017887 chr14:105400489 NA 0.68 13.09 0.58 7.04e-32 Rheumatoid arthritis; LUSC cis rs8114671 0.869 rs2145559 chr20:33651725 G/A cg07148914 chr20:33460835 GGT7 -0.48 -7.2 -0.37 3.97e-12 Height; LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg08280861 chr8:58055591 NA 0.52 5.68 0.3 2.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs68170813 0.641 rs61511581 chr7:106948091 T/A cg02696742 chr7:106810147 HBP1 -0.62 -9.39 -0.46 9.75e-19 Coronary artery disease; LUSC cis rs7000551 0.663 rs11778831 chr8:22335088 C/T cg12081754 chr8:22256438 SLC39A14 0.43 6.28 0.33 1.04e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg22907277 chr7:1156413 C7orf50 0.72 10.4 0.49 3.82e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9611519 1.000 rs5758267 chr22:41619350 A/T cg13813247 chr22:41461852 NA 0.33 6.19 0.32 1.77e-9 Neuroticism; LUSC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg03351412 chr1:154909251 PMVK 0.55 8.7 0.43 1.52e-16 Prostate cancer; LUSC cis rs2074585 0.583 rs28406958 chr15:91069364 C/A cg22089800 chr15:90895588 ZNF774 -0.57 -8.03 -0.4 1.68e-14 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs977987 0.806 rs4888418 chr16:75460306 C/G cg04384234 chr16:75411784 CFDP1 -0.43 -6.99 -0.36 1.54e-11 Dupuytren's disease; LUSC cis rs600231 0.542 rs34527830 chr11:65240863 G/A cg17120908 chr11:65337727 SSSCA1 -0.62 -8.95 -0.44 2.47e-17 Bone mineral density; LUSC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg26408565 chr15:76604113 ETFA 0.47 7.47 0.38 7.1e-13 Blood metabolite levels; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg15482792 chr1:91870014 HFM1 0.42 6.1 0.32 2.95e-9 Calcium levels; LUSC cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg08999081 chr20:33150536 PIGU 0.37 6.69 0.34 9.61e-11 Height; LUSC cis rs9747201 1.000 rs9303023 chr17:80175920 C/T cg18209359 chr17:80159595 CCDC57 -0.36 -5.82 -0.3 1.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7481584 0.624 rs369461 chr11:3061992 A/G cg05729581 chr11:3078854 CARS 0.41 5.95 0.31 6.91e-9 Calcium levels; LUSC cis rs2073300 1.000 rs17830565 chr20:23444805 G/A cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.11 -0.41 9.41e-15 Lung cancer; LUSC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg13607699 chr17:42295918 UBTF -0.47 -7.37 -0.37 1.32e-12 Total body bone mineral density; LUSC trans rs931812 0.825 rs35515344 chr8:101896769 C/G cg20993868 chr7:22813445 NA 0.6 10.46 0.5 2.54e-22 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg05535760 chr7:792225 HEATR2 0.8 9.68 0.47 1.04e-19 Cerebrospinal P-tau181p levels; LUSC cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.17 -0.37 4.96e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.58 9.04 0.44 1.29e-17 Menopause (age at onset); LUSC cis rs7659604 0.502 rs13106764 chr4:122699630 C/G cg20573242 chr4:122745356 CCNA2 -0.45 -6.73 -0.35 7.38e-11 Type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18672446 chr16:23160676 USP31 0.47 6.1 0.32 3.01e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6519955 0.796 rs4072455 chr22:46422938 T/C cg09693106 chr22:46449821 C22orf26;LOC150381 0.39 5.9 0.31 9.04e-9 Dupuytren's disease; LUSC cis rs11758351 1.000 rs80259160 chr6:26190199 C/T cg23601095 chr6:26197514 HIST1H3D 0.71 7.35 0.37 1.57e-12 Gout;Renal underexcretion gout; LUSC cis rs911555 0.723 rs2273701 chr14:103923225 G/T cg24130564 chr14:104152367 KLC1 0.45 6.51 0.34 2.72e-10 Intelligence (multi-trait analysis); LUSC trans rs62238980 0.614 rs117338422 chr22:32399226 C/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.02 -0.31 4.68e-9 Childhood ear infection; LUSC cis rs79349575 0.783 rs4793996 chr17:47019597 T/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs4663866 0.901 rs35713061 chr2:239183774 C/T cg16914508 chr2:239161102 PER2 0.66 6.99 0.36 1.46e-11 Irritable bowel syndrome; LUSC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg06221963 chr1:154839813 KCNN3 -0.62 -14.31 -0.62 1.47e-36 Prostate cancer; LUSC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg09367891 chr1:107599246 PRMT6 -0.54 -8.5 -0.42 6.26e-16 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs2979489 0.891 rs2915624 chr8:30381245 T/C cg26383811 chr8:30366931 RBPMS -0.53 -8.18 -0.41 6.08e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs6500602 0.727 rs4238849 chr16:4538114 G/A cg08645402 chr16:4508243 NA 0.48 8.15 0.41 7.22e-15 Schizophrenia; LUSC cis rs10865541 0.902 rs33997548 chr2:3419366 A/G cg15807143 chr2:3452624 TTC15 0.32 5.67 0.3 3.09e-8 Obesity-related traits; LUSC cis rs11605275 1.000 rs78687006 chr11:20032176 G/A cg14835545 chr11:20032148 NAV2 -0.86 -6.53 -0.34 2.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs694739 0.628 rs617051 chr11:64133638 C/A cg02228329 chr11:64053129 BAD;GPR137 0.44 6.23 0.32 1.37e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg14416269 chr4:6271139 WFS1 0.54 11.14 0.52 1e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7829975 0.514 rs2945873 chr8:8260445 C/T cg08975724 chr8:8085496 FLJ10661 0.51 7.95 0.4 2.84e-14 Mood instability; LUSC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg04546413 chr19:29218101 NA 0.71 11.9 0.55 1.8e-27 Methadone dose in opioid dependence; LUSC cis rs7428496 0.528 rs12639363 chr3:142292518 C/T cg16271453 chr3:142027066 XRN1 0.5 8.56 0.42 4.26e-16 Mean corpuscular hemoglobin; LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs4242434 0.892 rs11776549 chr8:22493124 C/T cg03733263 chr8:22462867 KIAA1967 0.86 13.23 0.59 2.07e-32 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs4356932 1.000 rs10025102 chr4:76955358 G/A cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs79839061 0.520 rs11730111 chr4:942833 C/T cg07828340 chr4:882639 GAK 1.01 10.45 0.5 2.66e-22 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.692 rs34272342 chr15:77012276 A/C cg26408565 chr15:76604113 ETFA -0.49 -7.88 -0.4 4.75e-14 Blood metabolite levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18851521 chr18:268131 THOC1 -0.48 -6.37 -0.33 6.23e-10 Bipolar disorder and schizophrenia; LUSC cis rs8014204 0.804 rs35641442 chr14:75207263 G/A cg06637938 chr14:75390232 RPS6KL1 0.66 11.13 0.52 1.11e-24 Caffeine consumption; LUSC cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC trans rs7829975 0.606 rs891570 chr8:8794454 G/A cg27411982 chr8:10470053 RP1L1 -0.36 -6.05 -0.31 3.93e-9 Mood instability; LUSC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg06697600 chr4:7070879 GRPEL1 -0.43 -7.46 -0.38 7.49e-13 Monocyte percentage of white cells; LUSC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg01879757 chr17:41196368 BRCA1 -0.45 -6.85 -0.35 3.63e-11 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14341449 chr11:18034693 SERGEF 0.48 6.8 0.35 4.94e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.79 -0.39 8.61e-14 Lymphocyte counts; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg11965913 chr1:205819406 PM20D1 0.93 19.06 0.72 2.57e-55 Menarche (age at onset); LUSC cis rs7113850 0.541 rs78737372 chr11:24233984 G/A ch.11.24196551F chr11:24239977 NA 1.01 9.09 0.45 8.71e-18 Bone fracture in osteoporosis; LUSC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs11190604 0.945 rs2495735 chr10:102338609 G/A cg07080220 chr10:102295463 HIF1AN 0.66 9.26 0.45 2.63e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg08999081 chr20:33150536 PIGU 0.53 10.46 0.5 2.5e-22 Coronary artery disease; LUSC cis rs2116941 0.523 rs8104608 chr19:10370133 G/A cg01850179 chr19:10340795 S1PR2 0.62 9.81 0.47 3.91e-20 Pulse pressure; LUSC cis rs9303401 0.659 rs34878689 chr17:56694330 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.66 0.57 2.74e-30 Cognitive test performance; LUSC cis rs7945718 0.806 rs7480572 chr11:12787048 T/C cg25843174 chr11:12811716 TEAD1 0.33 7.48 0.38 6.62e-13 Educational attainment (years of education); LUSC cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg03060546 chr3:49711283 APEH 0.56 7.79 0.39 8.65e-14 Resting heart rate; LUSC trans rs9467603 1.000 rs9467606 chr6:25809218 A/G cg06606381 chr12:133084897 FBRSL1 -0.61 -5.95 -0.31 6.75e-9 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.862 rs7410537 chr22:50317330 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.59 -0.5 9.01e-23 Schizophrenia; LUSC cis rs870825 0.616 rs4444873 chr4:185628406 A/G cg04058563 chr4:185651563 MLF1IP 0.87 12.82 0.57 7.31e-31 Blood protein levels; LUSC cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg04450456 chr4:17643702 FAM184B -0.41 -6.74 -0.35 7.06e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs74338693 0.666 rs7608672 chr2:166924851 G/A cg02187259 chr2:16804452 FAM49A 0.31 5.97 0.31 5.99e-9 Schizophrenia; LUSC trans rs11098499 0.954 rs10034623 chr4:120397829 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.68 0.34 9.89e-11 Corneal astigmatism; LUSC trans rs3857536 0.813 rs9354405 chr6:66948575 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.43 -5.97 -0.31 5.9e-9 Blood trace element (Cu levels); LUSC cis rs7945718 1.000 rs7945719 chr11:12748820 A/C cg25843174 chr11:12811716 TEAD1 0.32 7.04 0.36 1.09e-11 Educational attainment (years of education); LUSC cis rs2486288 0.656 rs8040185 chr15:45552081 G/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.89 -0.4 4.34e-14 Glomerular filtration rate; LUSC cis rs9303401 0.659 rs66514313 chr17:56714057 C/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.67 0.43 1.92e-16 Cognitive test performance; LUSC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg05472934 chr7:22766657 IL6 0.5 7.85 0.39 5.69e-14 Lung cancer; LUSC cis rs2307022 0.548 rs1465471 chr16:68396377 C/T cg02226672 chr16:68398533 SMPD3 0.32 6.05 0.31 3.84e-9 Body mass index; LUSC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg06453172 chr10:134556979 INPP5A 0.51 6.47 0.33 3.48e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4268898 0.697 rs10445892 chr2:24406958 T/C cg06627628 chr2:24431161 ITSN2 0.55 7.75 0.39 1.13e-13 Asthma; LUSC cis rs7089973 0.604 rs2420066 chr10:116583897 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.16 0.45 5.47e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg18357645 chr12:58087776 OS9 -0.5 -6.67 -0.34 1.03e-10 Multiple sclerosis; LUSC cis rs2346177 0.874 rs35462976 chr2:46649049 A/G cg02822958 chr2:46747628 ATP6V1E2 0.36 6.16 0.32 2.05e-9 HDL cholesterol; LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg27535305 chr1:53392650 SCP2 0.36 6.78 0.35 5.43e-11 Monocyte count; LUSC trans rs853679 0.599 rs202906 chr6:28011652 C/T cg01620082 chr3:125678407 NA 0.58 6.68 0.34 1.01e-10 Depression; LUSC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg05340658 chr4:99064831 C4orf37 0.65 10.96 0.51 4.28e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16628904 chr6:126661274 C6orf173 -0.45 -6.45 -0.33 3.92e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10761482 0.813 rs7087726 chr10:62162582 G/C cg18175470 chr10:62150864 ANK3 -0.57 -8.51 -0.42 6.1e-16 Schizophrenia; LUSC cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg08355456 chr11:67383691 NA 0.37 6.43 0.33 4.54e-10 Mean corpuscular volume; LUSC cis rs8072100 0.967 rs62076549 chr17:45579555 T/G cg08085267 chr17:45401833 C17orf57 0.54 8.62 0.43 2.68e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.23e-8 Total body bone mineral density; LUSC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg27541892 chr1:1571801 CDK11B -0.53 -8.39 -0.42 1.35e-15 Body mass index; LUSC cis rs1348850 0.874 rs12996447 chr2:178283592 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.24 0.37 3.1e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2708377 0.929 rs2597990 chr12:11203459 G/A cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.8 -7.83 -0.39 6.58e-14 Bitter taste perception; LUSC cis rs9815354 0.638 rs73073302 chr3:42029879 T/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs9747201 1.000 rs4506966 chr17:80175421 T/C cg18209359 chr17:80159595 CCDC57 -0.36 -5.82 -0.3 1.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7312933 0.524 rs11181465 chr12:42765098 T/G cg01256987 chr12:42539512 GXYLT1 -0.39 -7.22 -0.37 3.59e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg13902645 chr11:5959945 NA -0.56 -7.94 -0.4 3.1e-14 DNA methylation (variation); LUSC cis rs7911264 0.703 rs7894183 chr10:94382040 G/A cg25093409 chr10:94429542 NA 0.36 6.21 0.32 1.59e-9 Inflammatory bowel disease; LUSC cis rs4901869 0.966 rs9972206 chr14:59336095 A/G cg02291164 chr14:59296302 NA 0.57 10.88 0.51 8.53e-24 Panic disorder; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg13047869 chr3:10149882 C3orf24 0.62 8.64 0.43 2.39e-16 Alzheimer's disease; LUSC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg05373962 chr22:49881684 NA -0.42 -10.04 -0.48 6.56e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg11279151 chr3:101281821 RG9MTD1 -0.47 -7.19 -0.37 4.4e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1371867 0.846 rs1660353 chr8:101250907 C/T cg06636551 chr8:101224915 SPAG1 0.38 7.07 0.36 9.17e-12 Atrioventricular conduction; LUSC cis rs11785400 0.793 rs4736362 chr8:143741381 G/A cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg05165339 chr4:1420672 NA -0.3 -7.03 -0.36 1.18e-11 Longevity; LUSC cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.33 0.56 4.97e-29 Chronic sinus infection; LUSC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs2011503 1.000 rs1036215 chr19:19657198 C/T cg15839431 chr19:19639596 YJEFN3 -0.66 -6.93 -0.35 2.2e-11 Bipolar disorder; LUSC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg06634786 chr22:41940651 POLR3H -0.57 -6.89 -0.35 2.71e-11 Vitiligo; LUSC cis rs240764 0.782 rs369125 chr6:101118400 G/A cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs7085104 0.727 rs12773892 chr10:104631177 G/T cg04362960 chr10:104952993 NT5C2 1.03 11.72 0.54 8.13e-27 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.5 -7.2 -0.37 3.95e-12 Colorectal cancer; LUSC trans rs208520 0.526 rs1385219 chr6:66754476 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.19 23.81 0.79 5.99e-74 Exhaled nitric oxide output; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg09877947 chr5:131593287 PDLIM4 0.49 8.45 0.42 9.38e-16 Blood metabolite levels; LUSC trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg03929089 chr4:120376271 NA 0.64 6.98 0.36 1.61e-11 Axial length; LUSC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg08499158 chr17:42289980 UBTF 0.42 6.44 0.33 4.18e-10 Total body bone mineral density; LUSC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg14403583 chr14:105418241 AHNAK2 -0.57 -9.68 -0.47 1.1e-19 Rheumatoid arthritis; LUSC cis rs7587476 0.784 rs13026390 chr2:215687075 C/T cg04004882 chr2:215674386 BARD1 -0.43 -5.79 -0.3 1.64e-8 Neuroblastoma; LUSC cis rs6005807 0.640 rs73432205 chr22:29028132 C/T cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs9362426 0.708 rs7753821 chr6:88100010 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.38 6.3 0.33 9.54e-10 Depressive episodes in bipolar disorder; LUSC cis rs477692 1.000 rs567700 chr10:131423126 C/T cg11019008 chr10:131425282 MGMT 0.39 5.84 0.3 1.26e-8 Response to temozolomide; LUSC cis rs6456156 0.586 rs7742305 chr6:167485723 C/T cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg15534755 chr11:117069859 TAGLN 0.35 6.06 0.31 3.72e-9 Blood protein levels; LUSC cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg18681998 chr4:17616180 MED28 0.78 13.81 0.6 1.26e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11039100 0.607 rs34317277 chr11:5782186 A/C cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg12751644 chr20:60527061 NA -0.34 -6.0 -0.31 5.25e-9 Body mass index; LUSC cis rs4076764 0.801 rs6698738 chr1:163359918 G/A cg24596788 chr1:163392923 NA -0.39 -6.48 -0.33 3.25e-10 Motion sickness; LUSC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg04871131 chr7:94954202 PON1 -0.39 -6.11 -0.32 2.7e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg00129232 chr17:37814104 STARD3 -0.48 -7.23 -0.37 3.27e-12 Asthma; LUSC cis rs4690686 0.769 rs11133146 chr4:177278878 C/T cg17059388 chr4:177262070 NA -0.37 -7.33 -0.37 1.71e-12 Essential tremor; LUSC cis rs11608355 0.545 rs12818120 chr12:109901916 C/T cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.15e-26 Neuroticism; LUSC cis rs7223966 1.000 rs9747164 chr17:61864787 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.76 0.35 6.21e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg16339924 chr4:17578868 LAP3 -0.58 -8.38 -0.42 1.53e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs61931739 0.635 rs1601627 chr12:33962420 G/A cg26384229 chr12:38710491 ALG10B 0.51 7.62 0.38 2.61e-13 Morning vs. evening chronotype; LUSC trans rs877282 0.583 rs11253425 chr10:815173 G/A cg22713356 chr15:30763199 NA 0.73 9.32 0.45 1.67e-18 Uric acid levels; LUSC cis rs56283067 0.887 rs9463042 chr6:44770527 T/C cg20913747 chr6:44695427 NA -0.44 -6.98 -0.36 1.6e-11 Total body bone mineral density; LUSC cis rs909002 0.925 rs7524405 chr1:32108579 A/C cg01639898 chr1:32083012 HCRTR1 -0.25 -5.87 -0.31 1.08e-8 Intelligence (multi-trait analysis); LUSC trans rs17039065 0.920 rs79622192 chr4:109419632 G/A cg07444054 chr2:108107501 NA 0.45 6.29 0.33 1.01e-9 Gut microbiome composition (summer); LUSC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg17971929 chr21:40555470 PSMG1 -0.67 -11.27 -0.52 3.48e-25 Cognitive function; LUSC cis rs8114671 0.527 rs6060112 chr20:33489276 A/T cg24642439 chr20:33292090 TP53INP2 0.43 6.22 0.32 1.52e-9 Height; LUSC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.75 10.81 0.51 1.44e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg08742575 chr21:47604166 C21orf56 -0.42 -6.26 -0.32 1.2e-9 Testicular germ cell tumor; LUSC cis rs12519773 0.525 rs57542119 chr5:92538853 T/C cg18783429 chr5:92414398 NA 0.35 7.4 0.38 1.08e-12 Migraine; LUSC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg11663144 chr21:46675770 NA -0.4 -6.94 -0.36 2.04e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9560113 0.622 rs4773388 chr13:112195250 A/C cg10483660 chr13:112241077 NA 0.37 6.8 0.35 4.88e-11 Menarche (age at onset); LUSC cis rs2282802 0.685 rs7715538 chr5:139665181 T/C cg26211634 chr5:139558579 C5orf32 0.44 8.09 0.4 1.14e-14 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg23791538 chr6:167370224 RNASET2 -0.41 -6.56 -0.34 2.05e-10 Crohn's disease; LUSC cis rs73200209 0.744 rs57085207 chr12:116579289 T/C cg01776926 chr12:116560359 MED13L -0.51 -6.11 -0.32 2.71e-9 Total body bone mineral density; LUSC trans rs1268789 0.501 rs3762844 chr4:79365152 G/A cg06112894 chr8:141469983 TRAPPC9 0.22 5.96 0.31 6.33e-9 Hair shape;Hair morphology; LUSC cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg18681998 chr4:17616180 MED28 -0.82 -14.54 -0.62 1.84e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7408868 0.520 rs1043994 chr19:15302844 T/C cg14696996 chr19:15285081 NOTCH3 0.78 7.52 0.38 5.23e-13 Pulse pressure; LUSC cis rs2072499 0.833 rs2758605 chr1:156200445 G/C cg24450063 chr1:156163899 SLC25A44 1.1 22.24 0.77 6.99e-68 Testicular germ cell tumor; LUSC cis rs1348850 0.914 rs12469386 chr2:178358281 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.55 -7.34 -0.37 1.6e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12579753 1.000 rs34894912 chr12:82228721 A/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC trans rs62103177 0.608 rs8088089 chr18:77832154 A/G cg14227996 chr4:17616232 MED28 -0.54 -6.08 -0.32 3.37e-9 Opioid sensitivity; LUSC cis rs752010 0.644 rs6700390 chr1:42112554 A/G cg06885757 chr1:42089581 HIVEP3 0.49 9.81 0.47 4.1e-20 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs3126085 0.935 rs1858478 chr1:152257457 C/T cg26876637 chr1:152193138 HRNR -0.45 -6.08 -0.32 3.31e-9 Atopic dermatitis; LUSC trans rs2243480 1.000 rs2707844 chr7:66059509 G/A cg10756647 chr7:56101905 PSPH 0.88 8.95 0.44 2.46e-17 Diabetic kidney disease; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg22907277 chr7:1156413 C7orf50 0.49 7.51 0.38 5.46e-13 Longevity;Endometriosis; LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg00431813 chr7:1051703 C7orf50 -0.43 -7.37 -0.37 1.35e-12 Longevity;Endometriosis; LUSC cis rs9467773 0.649 rs2145318 chr6:26496603 T/A cg09904177 chr6:26538194 HMGN4 0.68 11.46 0.53 7.03e-26 Intelligence (multi-trait analysis); LUSC cis rs1580019 0.520 rs6945238 chr7:32646096 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.93 -12.9 -0.58 3.58e-31 Cognitive ability; LUSC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg18876405 chr7:65276391 NA 0.55 8.79 0.43 8.1e-17 Aortic root size; LUSC cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -7.98 -0.4 2.39e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg03929089 chr4:120376271 NA -0.67 -9.56 -0.46 2.6e-19 Coronary artery disease; LUSC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.49 0.59 2.14e-33 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3771570 1.000 rs62193204 chr2:242315443 A/G cg21155796 chr2:242212141 HDLBP 0.62 6.67 0.34 1.07e-10 Prostate cancer; LUSC cis rs8017423 0.967 rs7160032 chr14:90708472 A/G cg04374321 chr14:90722782 PSMC1 0.76 12.08 0.55 4.07e-28 Mortality in heart failure; LUSC cis rs11122272 0.735 rs2572249 chr1:231514829 G/A cg06096015 chr1:231504339 EGLN1 0.56 9.88 0.48 2.27e-20 Hemoglobin concentration; LUSC cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.54 -0.46 3.1e-19 Chronic sinus infection; LUSC cis rs7264396 0.790 rs6121018 chr20:34249060 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.68 -0.47 1.09e-19 Total cholesterol levels; LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg12564285 chr5:131593104 PDLIM4 -0.48 -8.29 -0.41 2.8e-15 Breast cancer; LUSC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg11764359 chr7:65958608 NA -0.53 -7.28 -0.37 2.34e-12 Aortic root size; LUSC cis rs7267979 0.966 rs4815414 chr20:25361701 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1832871 0.672 rs56326208 chr6:158762944 C/T cg07165851 chr6:158734300 TULP4 0.46 6.95 0.36 1.98e-11 Height; LUSC cis rs1451375 0.572 rs66792686 chr7:50651239 T/C cg18232548 chr7:50535776 DDC 0.47 6.13 0.32 2.54e-9 Malaria; LUSC cis rs10876993 0.715 rs2169987 chr12:58012111 G/A cg00268967 chr12:58002603 GEFT;DTX3 -0.36 -5.77 -0.3 1.77e-8 Celiac disease or Rheumatoid arthritis; LUSC cis rs7523050 0.730 rs72984614 chr1:109435848 T/C cg08274380 chr1:109419600 GPSM2 1.13 11.51 0.53 4.76e-26 Fat distribution (HIV); LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg15242686 chr22:24348715 GSTTP1 0.43 6.46 0.33 3.6e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs6957923 0.655 rs6949019 chr7:23594050 A/G cg21014120 chr2:203736523 ICA1L -0.42 -6.19 -0.32 1.79e-9 Height; LUSC cis rs1044826 0.518 rs295488 chr3:139239323 C/T cg15131784 chr3:139108705 COPB2 0.4 6.46 0.33 3.79e-10 Obesity-related traits; LUSC cis rs2637266 1.000 rs7896379 chr10:78366247 C/T cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs939658 0.683 rs1560895 chr15:79468082 A/G cg17916960 chr15:79447300 NA -0.42 -7.97 -0.4 2.59e-14 Refractive error; LUSC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08704250 chr15:31115839 NA 0.49 7.95 0.4 2.97e-14 Huntington's disease progression; LUSC cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.99 -0.36 1.51e-11 Blood metabolite levels; LUSC trans rs7395662 0.611 rs4882089 chr11:48515612 A/T cg15704280 chr7:45808275 SEPT13 -0.44 -6.1 -0.32 3e-9 HDL cholesterol; LUSC cis rs9916302 0.861 rs4795376 chr17:37669043 T/C cg15445000 chr17:37608096 MED1 0.41 6.91 0.35 2.41e-11 Glomerular filtration rate (creatinine); LUSC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg15445000 chr17:37608096 MED1 -0.38 -6.5 -0.34 2.88e-10 Glomerular filtration rate (creatinine); LUSC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg23985595 chr17:80112537 CCDC57 0.3 5.75 0.3 2.06e-8 Life satisfaction; LUSC cis rs77633900 0.772 rs2944377 chr15:76699652 C/A cg21673338 chr15:77095150 SCAPER -0.7 -5.99 -0.31 5.4e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -8.61 -0.43 2.96e-16 Lymphocyte counts; LUSC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg09085632 chr11:111637200 PPP2R1B -1.04 -16.32 -0.67 2.01e-44 Primary sclerosing cholangitis; LUSC cis rs1570884 0.516 rs9535268 chr13:50175478 C/A cg08779649 chr13:50194554 NA 0.41 6.92 0.35 2.27e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs10203711 0.933 rs7591829 chr2:239586185 A/T cg14580085 chr2:239553406 NA 0.39 6.47 0.33 3.56e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg13798912 chr7:905769 UNC84A -0.56 -5.89 -0.31 9.24e-9 Cerebrospinal P-tau181p levels; LUSC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.34e-12 Tonsillectomy; LUSC cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.74 -10.08 -0.48 4.84e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs225245 0.782 rs321599 chr17:33905745 C/T cg19694781 chr19:47549865 TMEM160 -0.41 -6.61 -0.34 1.51e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs8180040 0.966 rs13072802 chr3:47346415 G/C cg16586182 chr3:47516702 SCAP -0.48 -7.46 -0.38 7.78e-13 Colorectal cancer; LUSC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg23625390 chr15:77176239 SCAPER 0.43 6.45 0.33 3.81e-10 Blood metabolite levels; LUSC cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg13010199 chr12:38710504 ALG10B 0.65 9.81 0.47 3.95e-20 Bladder cancer; LUSC cis rs9560113 0.597 rs1163644 chr13:112241223 C/T cg10483660 chr13:112241077 NA -0.35 -6.17 -0.32 2.03e-9 Menarche (age at onset); LUSC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg11861562 chr11:117069780 TAGLN 0.44 7.9 0.4 4.17e-14 Blood protein levels; LUSC cis rs9393777 0.588 rs6456728 chr6:26477779 G/A cg12292205 chr6:26970375 C6orf41 -0.56 -6.82 -0.35 4.3e-11 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.908 rs1002152 chr4:120273387 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.3 0.33 9.38e-10 Corneal astigmatism; LUSC cis rs11295209 1 rs11295209 chr4:120480233 TA/T cg24375607 chr4:120327624 NA -0.46 -7.03 -0.36 1.18e-11 Plateletcrit; LUSC cis rs12618769 0.597 rs1847550 chr2:99052299 C/T cg10123293 chr2:99228465 UNC50 0.45 7.64 0.39 2.31e-13 Bipolar disorder; LUSC trans rs6952808 0.692 rs59619245 chr7:2068630 C/T cg04565464 chr8:145669602 NFKBIL2 0.41 6.53 0.34 2.44e-10 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg05347473 chr6:146136440 FBXO30 -0.49 -8.5 -0.42 6.18e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg01475377 chr6:109611718 NA -0.45 -8.27 -0.41 3.13e-15 Reticulocyte fraction of red cells; LUSC cis rs9527 0.662 rs4919686 chr10:104592249 A/C cg23093090 chr10:104574429 C10orf26 -0.38 -6.13 -0.32 2.43e-9 Arsenic metabolism; LUSC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg14061069 chr19:46274453 DMPK -0.51 -8.56 -0.42 4.28e-16 Coronary artery disease; LUSC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg06484146 chr7:12443880 VWDE -0.57 -6.03 -0.31 4.23e-9 Coronary artery disease; LUSC cis rs1003719 0.582 rs2835634 chr21:38528270 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.54 -0.5 1.26e-22 Eye color traits; LUSC cis rs10492096 0.947 rs12371184 chr12:6632925 A/G cg13857086 chr12:6580257 VAMP1 0.55 6.67 0.34 1.06e-10 Hip geometry; LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg04944784 chr2:26401820 FAM59B -0.74 -10.91 -0.51 6.48e-24 Gut microbiome composition (summer); LUSC cis rs59104589 0.617 rs60178325 chr2:242300651 A/T cg14842376 chr2:242211374 HDLBP 0.58 6.57 0.34 1.92e-10 Fibrinogen levels; LUSC cis rs8077889 0.956 rs55768269 chr17:41888997 C/T cg26893861 chr17:41843967 DUSP3 0.98 14.71 0.63 4.09e-38 Triglycerides; LUSC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg08392591 chr16:89556376 ANKRD11 0.44 6.55 0.34 2.16e-10 Multiple myeloma (IgH translocation); LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg26338869 chr17:61819248 STRADA 0.41 5.95 0.31 6.66e-9 Prudent dietary pattern; LUSC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg20891558 chr2:74357851 NA 0.83 15.71 0.65 4.76e-42 Gestational age at birth (maternal effect); LUSC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.92 0.31 8.01e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.43 0.42 1.08e-15 Prudent dietary pattern; LUSC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg12257692 chr3:49977190 RBM6 -0.24 -6.6 -0.34 1.66e-10 Intelligence (multi-trait analysis); LUSC cis rs28647808 0.786 rs4962134 chr9:136256626 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs55675132 0.879 rs12130654 chr1:115626392 G/C cg01522456 chr1:115632236 TSPAN2 -0.47 -6.09 -0.32 3.05e-9 Schizophrenia; LUSC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.19 0.59 2.84e-32 Hip circumference adjusted for BMI; LUSC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg06074448 chr4:187884817 NA -0.41 -6.91 -0.35 2.47e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.56 0.5 1.11e-22 Homoarginine levels; LUSC cis rs6906287 0.647 rs7758614 chr6:118889894 T/C cg21191810 chr6:118973309 C6orf204 0.32 5.98 0.31 5.63e-9 Electrocardiographic conduction measures; LUSC cis rs6546550 0.901 rs11902198 chr2:70144596 C/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs2070488 0.636 rs2284817 chr3:38510388 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 9.99 0.48 9.66e-21 Electrocardiographic conduction measures; LUSC cis rs11958404 0.932 rs112993559 chr5:157414712 A/C cg05962755 chr5:157440814 NA 0.5 6.14 0.32 2.38e-9 IgG glycosylation; LUSC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg24250549 chr1:154909240 PMVK 0.44 6.58 0.34 1.87e-10 Prostate cancer; LUSC cis rs11677370 0.561 rs12711973 chr2:3825339 C/G cg17052675 chr2:3827356 NA -0.59 -9.43 -0.46 7.17e-19 Type 2 diabetes; LUSC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg01181863 chr3:195395398 SDHAP2 -0.59 -8.08 -0.4 1.21e-14 Pancreatic cancer; LUSC cis rs8133932 0.608 rs382195 chr21:47339222 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.78 -0.3 1.75e-8 Schizophrenia; LUSC cis rs9914988 0.887 rs11080072 chr17:27081160 G/T cg09479241 chr17:27052676 TLCD1 0.4 5.71 0.3 2.5e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs1927790 0.643 rs9556574 chr13:97011649 T/G cg03198741 chr6:1003969 LOC285768 -0.39 -5.96 -0.31 6.5e-9 Body mass index; LUSC cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg23583168 chr7:148888333 NA -0.92 -17.41 -0.69 9.48e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs3008870 1.000 rs912797 chr1:67413478 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.26 0.64 2.91e-40 Lymphocyte percentage of white cells; LUSC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg19920283 chr7:105172520 RINT1 0.6 6.38 0.33 5.9e-10 Bipolar disorder (body mass index interaction); LUSC cis rs73001065 0.688 rs59148799 chr19:19484008 A/G cg03709012 chr19:19516395 GATAD2A 0.95 8.66 0.43 2.11e-16 LDL cholesterol; LUSC cis rs3859192 0.561 rs34453912 chr17:38180352 T/A cg17467752 chr17:38218738 THRA -0.51 -7.3 -0.37 2.09e-12 White blood cell count; LUSC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.57 0.38 3.63e-13 Multiple sclerosis; LUSC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg06238570 chr21:40685208 BRWD1 0.44 6.67 0.34 1.07e-10 Cognitive function; LUSC cis rs12776158 1.000 rs12776158 chr10:71218094 T/C cg12610070 chr10:71211762 TSPAN15 -0.5 -6.81 -0.35 4.52e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs950027 0.572 rs12910764 chr15:45609360 T/C cg04036182 chr15:45458818 NA -0.35 -5.65 -0.3 3.42e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs7193541 0.684 rs9923145 chr16:74686166 G/A cg01733217 chr16:74700730 RFWD3 0.98 22.16 0.77 1.52e-67 Multiple myeloma; LUSC cis rs2463822 0.844 rs72923263 chr11:62161170 C/G cg06239285 chr11:62104954 ASRGL1 -0.96 -10.27 -0.49 1.13e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.68 0.47 1.09e-19 Bipolar disorder; LUSC cis rs9399135 0.660 rs9376072 chr6:135280519 G/C cg24558204 chr6:135376177 HBS1L 0.56 8.56 0.42 4.17e-16 Red blood cell count; LUSC cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg21918786 chr6:109611834 NA -0.4 -6.93 -0.35 2.14e-11 Reticulocyte fraction of red cells; LUSC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg25282410 chr6:160211355 TCP1;MRPL18 1.1 16.88 0.68 1.19e-46 Age-related macular degeneration (geographic atrophy); LUSC cis rs7180079 1.000 rs2062249 chr15:64672159 C/A cg08069370 chr15:64387884 SNX1 0.63 6.19 0.32 1.77e-9 Monocyte count; LUSC cis rs75920871 0.528 rs11216255 chr11:116929995 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.48 -6.15 -0.32 2.24e-9 Subjective well-being; LUSC cis rs4595586 0.545 rs67985200 chr12:39386891 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.07 0.32 3.39e-9 Morning vs. evening chronotype; LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg07507251 chr3:52567010 NT5DC2 0.34 6.68 0.34 1e-10 Bipolar disorder; LUSC cis rs6700896 0.500 rs4655556 chr1:66080563 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg16524733 chr11:117070046 TAGLN 0.43 7.62 0.38 2.64e-13 Blood protein levels; LUSC cis rs1448094 1.000 rs1448094 chr12:86343135 G/T cg02569458 chr12:86230093 RASSF9 0.42 6.73 0.35 7.42e-11 Major depressive disorder; LUSC cis rs7246657 0.943 rs34603719 chr19:37794528 T/G cg23950597 chr19:37808831 NA -0.62 -7.31 -0.37 2e-12 Coronary artery calcification; LUSC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg12463550 chr7:65579703 CRCP 0.51 7.37 0.37 1.33e-12 Aortic root size; LUSC trans rs72674100 1.000 rs60708023 chr4:97984500 A/G cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6933660 0.610 rs71549125 chr6:151770796 A/C cg10883421 chr6:151773342 RMND1;C6orf211 0.78 12.63 0.57 3.7e-30 Menarche (age at onset); LUSC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg22800045 chr5:56110881 MAP3K1 0.46 6.44 0.33 4.08e-10 Breast cancer;Breast cancer (early onset); LUSC cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.82 0.43 6.31e-17 Axial length; LUSC cis rs7917772 0.604 rs10883756 chr10:104400112 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.55 -7.72 -0.39 1.38e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1670533 1.000 rs641987 chr4:1077542 C/T cg02018176 chr4:1364513 KIAA1530 0.46 6.53 0.34 2.46e-10 Recombination rate (females); LUSC trans rs2204008 0.713 rs11173567 chr12:38089375 T/C cg06521331 chr12:34319734 NA -0.44 -6.61 -0.34 1.54e-10 Bladder cancer; LUSC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg16339924 chr4:17578868 LAP3 0.64 10.13 0.48 3.18e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.74 0.51 2.63e-23 Hip circumference adjusted for BMI; LUSC cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg23711669 chr6:146136114 FBXO30 0.86 15.5 0.65 3.42e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs76248362 1.000 rs9510908 chr13:24435768 C/T cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs6987853 0.666 rs2923403 chr8:42447748 G/T cg09913449 chr8:42400586 C8orf40 0.49 8.47 0.42 7.97e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg02153584 chr22:29168773 CCDC117 0.59 8.8 0.43 7.31e-17 Lymphocyte counts; LUSC cis rs9549260 0.755 rs4943797 chr13:41201633 A/G cg21288729 chr13:41239152 FOXO1 -0.61 -9.39 -0.46 9.97e-19 Red blood cell count; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg12419862 chr22:24373484 LOC391322 -0.99 -18.41 -0.71 9.9e-53 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7937682 0.883 rs517982 chr11:111462687 T/C cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs3540 0.533 rs12708585 chr15:91052285 C/T cg10434728 chr15:90938212 IQGAP1 -0.45 -9.14 -0.45 6.18e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg11102782 chr19:18549136 ISYNA1 -0.37 -6.96 -0.36 1.76e-11 Breast cancer; LUSC cis rs7833986 1.000 rs36103212 chr8:57101475 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.6 8.88 0.44 4.2e-17 Height; LUSC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg09835421 chr16:68378352 PRMT7 -0.55 -6.16 -0.32 2.09e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg08997352 chr12:9597637 DDX12 -0.6 -9.39 -0.46 9.78e-19 Breast size; LUSC cis rs9300255 0.722 rs11830103 chr12:123823546 A/G cg13010344 chr12:123464640 ARL6IP4 0.49 6.44 0.33 4.06e-10 Neutrophil percentage of white cells; LUSC cis rs8113142 0.614 rs59394095 chr19:29192112 C/A cg04546413 chr19:29218101 NA 0.47 6.37 0.33 6.15e-10 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -7.2 -0.37 4.02e-12 Alzheimer's disease (late onset); LUSC cis rs4604732 0.588 rs9943231 chr1:247629829 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.79 0.35 5.06e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -14.08 -0.61 1.14e-35 Extrinsic epigenetic age acceleration; LUSC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg16405210 chr4:1374714 KIAA1530 -0.49 -7.21 -0.37 3.82e-12 Obesity-related traits; LUSC cis rs61931739 0.534 rs7310499 chr12:34212112 G/A cg06521331 chr12:34319734 NA -0.46 -7.59 -0.38 3.27e-13 Morning vs. evening chronotype; LUSC cis rs7575217 0.767 rs6543018 chr2:101730288 A/G cg23907051 chr2:101730305 TBC1D8 0.3 8.24 0.41 3.85e-15 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs1729951 0.575 rs16844326 chr3:136678385 G/C cg21827317 chr3:136751795 NA 0.39 6.91 0.35 2.41e-11 Neuroticism; LUSC trans rs1459104 0.866 rs12804916 chr11:54831763 G/A cg15704280 chr7:45808275 SEPT13 0.76 6.64 0.34 1.24e-10 Body mass index; LUSC trans rs2729385 1.000 rs2729385 chr11:57262993 C/T cg07172676 chr8:144997714 PLEC1 -0.47 -6.05 -0.31 3.97e-9 Interleukin-18 levels; LUSC cis rs6424115 0.830 rs2501425 chr1:24199339 A/C cg15997130 chr1:24165203 NA 0.52 8.58 0.42 3.67e-16 Immature fraction of reticulocytes; LUSC cis rs1983891 1.000 rs4714486 chr6:41542417 C/T cg20194872 chr6:41519635 FOXP4 0.37 6.49 0.33 3.11e-10 Prostate cancer; LUSC cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.89 0.4 4.34e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg26395211 chr5:140044315 WDR55 0.44 6.81 0.35 4.6e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg24813613 chr7:1882135 MAD1L1 -0.36 -5.86 -0.31 1.08e-8 Bipolar disorder and schizophrenia; LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg13047869 chr3:10149882 C3orf24 0.57 7.95 0.4 2.83e-14 Alzheimer's disease; LUSC cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg27446573 chr6:127587934 RNF146 0.9 14.86 0.63 1.12e-38 Breast cancer; LUSC cis rs4919694 0.615 rs78384860 chr10:105003019 G/T cg04362960 chr10:104952993 NT5C2 1.22 13.15 0.58 4.2e-32 Arsenic metabolism; LUSC cis rs10823500 0.748 rs7072230 chr10:71978144 A/G cg02100629 chr10:71892760 AIFM2 -0.36 -5.79 -0.3 1.66e-8 Blood protein levels; LUSC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg01448562 chr3:133502909 NA -0.53 -7.8 -0.39 8.02e-14 Iron status biomarkers; LUSC cis rs9329221 0.905 rs4610752 chr8:10248962 A/G cg21775007 chr8:11205619 TDH -0.56 -8.29 -0.41 2.72e-15 Neuroticism; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.51 0.42 6.06e-16 Prudent dietary pattern; LUSC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg10523679 chr1:76189770 ACADM 0.9 16.22 0.66 4.63e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7246967 0.673 rs2112610 chr19:22916851 C/T cg23217946 chr19:22817039 ZNF492 0.44 6.09 0.32 3.08e-9 Bronchopulmonary dysplasia; LUSC cis rs72627509 0.680 rs66790703 chr4:57773908 G/A cg26694713 chr4:57773883 REST 0.52 6.36 0.33 6.73e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg23283495 chr1:209979779 IRF6 0.62 7.66 0.39 1.99e-13 Cleft lip with or without cleft palate; LUSC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg04414720 chr1:150670196 GOLPH3L 0.53 8.23 0.41 4.4e-15 Melanoma; LUSC cis rs9660992 0.662 rs12092492 chr1:205251880 T/C cg00857998 chr1:205179979 DSTYK 0.53 7.98 0.4 2.42e-14 Mean corpuscular volume;Mean platelet volume; LUSC trans rs877282 0.945 rs10904550 chr10:774177 C/T cg22713356 chr15:30763199 NA 1.06 15.17 0.64 6.53e-40 Uric acid levels; LUSC cis rs9534288 0.699 rs1409432 chr13:46668302 C/T cg15192986 chr13:46630673 CPB2 -0.7 -10.16 -0.49 2.51e-21 Blood protein levels; LUSC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg17376030 chr22:41985996 PMM1 -0.47 -5.94 -0.31 7.32e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg00024416 chr22:24240387 NA 0.47 7.22 0.37 3.58e-12 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs7937682 0.883 rs1612013 chr11:111456293 A/G cg19812747 chr11:111475976 SIK2 -0.55 -8.08 -0.4 1.16e-14 Primary sclerosing cholangitis; LUSC cis rs6121246 0.909 rs6060679 chr20:30270772 C/G cg21427119 chr20:30132790 HM13 0.38 5.89 0.31 9.29e-9 Mean corpuscular hemoglobin; LUSC cis rs1891275 0.515 rs7092884 chr10:93483872 A/C cg07889827 chr10:93443413 NA 0.41 9.47 0.46 5.11e-19 Intelligence (multi-trait analysis); LUSC trans rs62238980 0.614 rs78593283 chr22:32365433 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -5.99 -0.31 5.43e-9 Childhood ear infection; LUSC cis rs13191362 0.507 rs1079020 chr6:163066596 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.54 -7.98 -0.4 2.3e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg00864171 chr11:67383662 NA -0.37 -6.55 -0.34 2.15e-10 Mean corpuscular volume; LUSC cis rs17253792 0.822 rs10083493 chr14:56045411 C/T cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs11031096 0.711 rs12270809 chr11:4206537 G/A cg18678763 chr11:4115507 RRM1 -0.42 -5.96 -0.31 6.32e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1595825 0.786 rs79490184 chr2:198894219 T/A cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg18225595 chr11:63971243 STIP1 0.52 6.06 0.31 3.67e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6429082 0.818 rs167092 chr1:235642359 A/G cg26050004 chr1:235667680 B3GALNT2 0.61 8.36 0.42 1.67e-15 Adiposity; LUSC cis rs1153858 1.000 rs1153858 chr15:45652703 A/G cg21132104 chr15:45694354 SPATA5L1 -0.58 -8.27 -0.41 3.13e-15 Homoarginine levels; LUSC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg09703963 chr11:616879 IRF7;MUPCDH -0.43 -6.7 -0.34 9.04e-11 Systemic lupus erythematosus; LUSC trans rs7980799 0.682 rs10161491 chr12:33623806 T/C cg26384229 chr12:38710491 ALG10B -0.59 -8.8 -0.43 7.7e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg17848003 chr1:3704513 LRRC47 0.32 5.81 0.3 1.46e-8 Red cell distribution width; LUSC cis rs9329221 0.725 rs11250001 chr8:10255901 G/A cg21775007 chr8:11205619 TDH -0.46 -5.94 -0.31 7.31e-9 Neuroticism; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01585723 chr16:33734837 NA -0.44 -7.61 -0.38 2.74e-13 Menopause (age at onset); LUSC cis rs2354432 0.607 rs9782976 chr1:146825049 A/G cg25205988 chr1:146714368 CHD1L 0.88 9.17 0.45 5.1e-18 Mitochondrial DNA levels; LUSC cis rs4631830 0.720 rs2611475 chr10:51503178 G/A cg10326726 chr10:51549505 MSMB -0.35 -6.12 -0.32 2.58e-9 Prostate-specific antigen levels; LUSC cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.42 -0.38 9.65e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs3820068 0.705 rs4646096 chr1:15820758 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.86 0.31 1.08e-8 Systolic blood pressure; LUSC cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg05347473 chr6:146136440 FBXO30 0.46 7.96 0.4 2.72e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg15839431 chr19:19639596 YJEFN3 -0.66 -7.28 -0.37 2.39e-12 Bipolar disorder; LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg25036284 chr2:26402008 FAM59B -0.73 -10.66 -0.5 4.85e-23 Gut microbiome composition (summer); LUSC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg13683864 chr3:40499215 RPL14 -1.13 -21.27 -0.76 4.56e-64 Renal cell carcinoma; LUSC trans rs61931739 0.782 rs7969373 chr12:34249655 T/G cg13010199 chr12:38710504 ALG10B 0.39 6.2 0.32 1.64e-9 Morning vs. evening chronotype; LUSC cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg15691649 chr6:25882328 NA -0.38 -6.11 -0.32 2.8e-9 Blood metabolite levels; LUSC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg24531977 chr5:56204891 C5orf35 -0.89 -13.75 -0.6 2.2e-34 Initial pursuit acceleration; LUSC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg02269571 chr22:50332266 NA 0.59 8.72 0.43 1.32e-16 Schizophrenia; LUSC cis rs9361491 0.657 rs13198615 chr6:79430552 A/G cg05283184 chr6:79620031 NA -0.33 -5.9 -0.31 8.93e-9 Intelligence (multi-trait analysis); LUSC cis rs11112613 0.713 rs68053161 chr12:105950035 G/C cg03607813 chr12:105948248 NA 0.82 12.44 0.56 1.96e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg03351412 chr1:154909251 PMVK 0.53 8.34 0.42 1.98e-15 Prostate cancer; LUSC cis rs6005807 0.563 rs9620811 chr22:29058409 T/C cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC trans rs3733585 0.699 rs6449178 chr4:9968684 A/G cg26043149 chr18:55253948 FECH 0.43 6.71 0.34 8.19e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2046867 0.818 rs62249866 chr3:72878632 T/C cg25664220 chr3:72788482 NA -0.69 -11.14 -0.52 1.05e-24 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9303401 0.615 rs7502342 chr17:56922629 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.67 0.6 4.46e-34 Cognitive test performance; LUSC cis rs12220238 0.818 rs10430521 chr10:75913590 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.96 0.36 1.79e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs6582630 0.559 rs12318620 chr12:38522340 T/C cg13010199 chr12:38710504 ALG10B -0.44 -6.72 -0.35 7.76e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs921968 0.643 rs1516086 chr2:219431535 C/T cg02176678 chr2:219576539 TTLL4 0.62 11.0 0.52 3.13e-24 Mean corpuscular hemoglobin concentration; LUSC trans rs931812 0.757 rs35569317 chr8:101907971 T/C cg20993868 chr7:22813445 NA 0.53 9.95 0.48 1.33e-20 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs9815354 0.812 rs59873855 chr3:41929538 T/C cg03022575 chr3:42003672 ULK4 0.7 7.5 0.38 5.93e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs9952991 0.941 rs7237497 chr18:12777325 T/C cg23598886 chr18:12777645 NA 0.65 6.6 0.34 1.61e-10 Inflammatory skin disease; LUSC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg21665744 chr7:39171113 POU6F2 0.43 6.95 0.36 1.96e-11 IgG glycosylation; LUSC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg17764715 chr19:33622953 WDR88 0.52 7.76 0.39 1.03e-13 Bone properties (heel); LUSC cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg09469691 chr10:81107165 PPIF 0.65 9.25 0.45 2.75e-18 Height; LUSC cis rs7119038 0.774 rs73005426 chr11:118681083 A/G cg19308663 chr11:118741387 NA 0.34 6.09 0.32 3.07e-9 Sjögren's syndrome; LUSC cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg26395211 chr5:140044315 WDR55 -0.39 -5.98 -0.31 5.69e-9 Depressive symptoms (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02652260 chr21:18985383 BTG3 0.76 6.2 0.32 1.64e-9 Cognitive performance; LUSC cis rs7927592 0.956 rs11228277 chr11:68308324 G/A cg16797656 chr11:68205561 LRP5 0.36 6.1 0.32 2.96e-9 Total body bone mineral density; LUSC cis rs469568 0.562 rs11741099 chr5:178664463 A/G cg08999896 chr5:178685787 ADAMTS2 0.43 8.28 0.41 3.02e-15 Stroke (pediatric); LUSC cis rs6582630 0.555 rs8189479 chr12:38308240 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.5 -0.42 6.28e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg19920283 chr7:105172520 RINT1 0.58 6.12 0.32 2.65e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9393777 0.841 rs67092078 chr6:27054772 G/A cg26958806 chr6:27640298 NA 0.77 5.91 0.31 8.37e-9 Intelligence (multi-trait analysis); LUSC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.4 -5.73 -0.3 2.2e-8 Tonsillectomy; LUSC cis rs6750047 0.647 rs11124632 chr2:38276412 G/C cg07380506 chr2:38303506 CYP1B1 0.47 6.59 0.34 1.72e-10 Cutaneous malignant melanoma;Melanoma; LUSC cis rs6738485 0.531 rs72819612 chr2:106846316 T/C cg16099169 chr2:106886729 NA -0.58 -6.81 -0.35 4.59e-11 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg00945038 chr17:61921165 SMARCD2 0.54 9.67 0.47 1.13e-19 Prudent dietary pattern; LUSC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg02038168 chr22:39784481 NA -0.47 -7.86 -0.4 5.34e-14 Intelligence (multi-trait analysis); LUSC cis rs4704187 0.687 rs6869345 chr5:74378742 C/T cg03227963 chr5:74354835 NA 0.31 6.73 0.35 7.4e-11 Response to amphetamines; LUSC cis rs240764 0.658 rs4840155 chr6:101253942 G/T cg09795085 chr6:101329169 ASCC3 -0.46 -6.56 -0.34 2.01e-10 Neuroticism; LUSC cis rs1062746 0.558 rs889608 chr16:87337543 A/G cg02258303 chr16:87377426 FBXO31 -0.54 -8.65 -0.43 2.19e-16 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs644799 0.710 rs523153 chr11:95570961 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.82 12.66 0.57 2.76e-30 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2348418 0.831 rs1581074 chr12:28723964 C/T cg13890972 chr12:28721907 NA -0.36 -6.14 -0.32 2.32e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs4253772 0.872 rs45552534 chr22:46638171 G/A cg24881330 chr22:46731750 TRMU 0.63 5.85 0.31 1.15e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs2243480 0.901 rs35823062 chr7:65965821 A/G cg10756647 chr7:56101905 PSPH 0.87 8.83 0.44 5.94e-17 Diabetic kidney disease; LUSC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg13206674 chr6:150067644 NUP43 0.52 7.94 0.4 3.01e-14 Lung cancer; LUSC cis rs7296418 0.961 rs12425850 chr12:123501972 T/C cg05973401 chr12:123451056 ABCB9 0.64 9.38 0.46 1.04e-18 Platelet count; LUSC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.07 0.4 1.3e-14 Melanoma; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg16132339 chr22:24313637 DDTL;DDT 0.4 6.35 0.33 6.96e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg09021430 chr5:549028 NA -0.55 -7.18 -0.37 4.44e-12 Lung disease severity in cystic fibrosis; LUSC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.08 -0.36 8.55e-12 Menopause (age at onset); LUSC cis rs9399135 0.816 rs4134030 chr6:135354094 G/T cg22676075 chr6:135203613 NA 0.47 7.38 0.37 1.3e-12 Red blood cell count; LUSC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.63e-8 Depression; LUSC cis rs7917772 0.565 rs1043450 chr10:104434209 A/G cg22532475 chr10:104410764 TRIM8 -0.37 -7.68 -0.39 1.8e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7572644 0.766 rs10168171 chr2:28232087 C/T cg27432699 chr2:27873401 GPN1 0.53 6.63 0.34 1.35e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg27129171 chr3:47204927 SETD2 -0.57 -8.21 -0.41 4.78e-15 Birth weight; LUSC cis rs7291412 1.000 rs7291412 chr22:46459132 G/T cg00785112 chr22:46450059 C22orf26;LOC150381 0.41 6.47 0.33 3.43e-10 Dupuytren's disease;Subjective well-being; LUSC cis rs6700896 0.931 rs10889569 chr1:66086194 A/T cg04111102 chr1:66153794 NA 0.32 7.07 0.36 8.85e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10927875 0.757 rs4661679 chr1:16321010 C/T cg22431228 chr1:16359049 CLCNKA -0.37 -7.57 -0.38 3.62e-13 Dilated cardiomyopathy; LUSC cis rs3850699 0.683 rs67646802 chr10:104303748 C/T cg04362960 chr10:104952993 NT5C2 0.48 6.45 0.33 3.9e-10 Prostate cancer; LUSC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg14773178 chr5:1868261 NA 0.31 5.72 0.3 2.38e-8 Cardiovascular disease risk factors; LUSC cis rs1865760 0.892 rs2328903 chr6:25935765 T/C cg17691542 chr6:26056736 HIST1H1C 0.47 7.0 0.36 1.44e-11 Height; LUSC cis rs10489525 0.583 rs6691374 chr1:115642818 T/C cg01522456 chr1:115632236 TSPAN2 0.69 10.08 0.48 4.95e-21 Autism; LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.75 0.77 5.71e-66 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.61e-29 Prudent dietary pattern; LUSC cis rs28647808 0.881 rs71483208 chr9:136258824 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg27129171 chr3:47204927 SETD2 0.7 11.72 0.54 8.25e-27 Colorectal cancer; LUSC cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.25 -0.45 2.85e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg25767906 chr1:53392781 SCP2 -0.34 -5.7 -0.3 2.59e-8 Monocyte count; LUSC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg04450456 chr4:17643702 FAM184B 0.36 6.05 0.31 3.87e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg05802129 chr4:122689817 NA -0.52 -8.77 -0.43 9.01e-17 Type 2 diabetes; LUSC cis rs11166629 1.000 rs6992668 chr8:135645129 T/C cg21672855 chr8:135614777 ZFAT 0.36 5.78 0.3 1.7e-8 Smoking quantity; LUSC cis rs10751667 0.666 rs6597958 chr11:978087 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.3e-10 Alzheimer's disease (late onset); LUSC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg06221963 chr1:154839813 KCNN3 -0.62 -13.98 -0.61 2.77e-35 Prostate cancer; LUSC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg13939156 chr17:80058883 NA -0.33 -6.43 -0.33 4.4e-10 Life satisfaction; LUSC cis rs9467773 1.000 rs9357010 chr6:26527945 C/G cg05738196 chr6:26577821 NA 0.81 15.71 0.65 4.98e-42 Intelligence (multi-trait analysis); LUSC cis rs477692 0.905 rs555545 chr10:131411586 G/A cg26102564 chr10:131424627 MGMT 0.41 6.4 0.33 5.35e-10 Response to temozolomide; LUSC cis rs870825 0.929 rs72689272 chr4:185592515 T/C cg04058563 chr4:185651563 MLF1IP 0.84 11.77 0.54 5.29e-27 Blood protein levels; LUSC cis rs752010 0.806 rs6696511 chr1:42110888 T/C cg06885757 chr1:42089581 HIVEP3 0.57 11.64 0.54 1.69e-26 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg22782873 chr19:19639568 YJEFN3 -0.5 -6.21 -0.32 1.58e-9 Bipolar disorder; LUSC cis rs4253772 0.872 rs41362646 chr22:46633505 G/A cg18190219 chr22:46762943 CELSR1 -0.51 -5.93 -0.31 7.62e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4285028 0.898 rs4305455 chr3:121619774 T/C cg11130432 chr3:121712080 ILDR1 -0.62 -9.63 -0.47 1.55e-19 Multiple sclerosis; LUSC cis rs4845570 1.000 rs11585294 chr1:151769887 A/C cg07092448 chr1:151763213 TDRKH -1.28 -14.36 -0.62 9.27e-37 Coronary artery disease; LUSC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7789940 0.904 rs56919252 chr7:75937520 T/C cg15798862 chr7:76129360 DTX2 -0.46 -7.46 -0.38 7.36e-13 Multiple sclerosis; LUSC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg03609598 chr5:56110824 MAP3K1 -0.41 -6.14 -0.32 2.39e-9 Initial pursuit acceleration; LUSC cis rs10992471 0.528 rs7037194 chr9:95216745 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.27 -0.32 1.14e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs10221833 0.602 rs355887 chr2:165634262 T/C cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.44e-9 Response to statin therapy; LUSC cis rs9402673 0.558 rs9688342 chr6:135323026 A/T cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Reticulocyte count;High light scatter reticulocyte count; LUSC cis rs76878669 0.561 rs11823140 chr11:66098322 G/T cg24851651 chr11:66362959 CCS 0.4 6.25 0.32 1.25e-9 Educational attainment (years of education); LUSC cis rs911119 0.955 rs7270413 chr20:23593821 C/G cg16589663 chr20:23618590 CST3 0.58 6.79 0.35 4.99e-11 Chronic kidney disease; LUSC cis rs72781680 0.898 rs718139 chr2:23975911 G/A cg08917208 chr2:24149416 ATAD2B 0.98 9.92 0.48 1.76e-20 Lymphocyte counts; LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg26119090 chr2:26468346 HADHA;HADHB 1.07 15.92 0.66 7.59e-43 Gut microbiome composition (summer); LUSC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg09323728 chr8:95962352 TP53INP1 0.35 7.3 0.37 2.08e-12 Type 2 diabetes; LUSC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.15 -0.36 5.59e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11637445 0.627 rs72751453 chr15:68124665 C/A cg08079166 chr15:68083412 MAP2K5 -0.37 -7.47 -0.38 6.95e-13 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.51 7.19 0.37 4.23e-12 Tonsillectomy; LUSC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg05347473 chr6:146136440 FBXO30 0.56 9.54 0.46 3.19e-19 Lobe attachment (rater-scored or self-reported); LUSC trans rs2392780 0.536 rs606345 chr8:128334499 T/A cg10195415 chr17:73887371 TRIM65 0.41 6.57 0.34 1.93e-10 Breast cancer (early onset); LUSC cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs459571 0.920 rs2520094 chr9:136919985 A/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.41 -5.96 -0.31 6.45e-9 Platelet distribution width; LUSC cis rs77633900 0.614 rs280028 chr15:77031466 A/G cg21673338 chr15:77095150 SCAPER -0.82 -8.07 -0.4 1.26e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs748404 0.578 rs507178 chr15:43610135 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.47 6.6 0.34 1.63e-10 Lung cancer; LUSC cis rs1729407 0.659 rs2542050 chr11:116697117 C/A cg08985259 chr11:116699649 APOC3 -0.25 -5.71 -0.3 2.48e-8 Apolipoprotein A-IV levels; LUSC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.0 0.66 3.55e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.85 0.51 1.06e-23 Monocyte percentage of white cells; LUSC trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg15704280 chr7:45808275 SEPT13 0.73 8.39 0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg23158103 chr7:148848205 ZNF398 -0.48 -8.05 -0.4 1.5e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.36 -0.37 1.45e-12 Height; LUSC cis rs6728642 0.572 rs13387563 chr2:97600916 C/A cg26665480 chr2:98280029 ACTR1B -0.76 -7.61 -0.38 2.78e-13 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs554111 0.656 rs12021529 chr1:21306161 C/T cg01072550 chr1:21505969 NA -0.41 -6.49 -0.33 3.17e-10 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg27427491 chr17:78079615 GAA -0.35 -6.78 -0.35 5.37e-11 Yeast infection; LUSC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.77 -0.43 9.44e-17 Personality dimensions; LUSC trans rs9929218 0.859 rs9936682 chr16:68748223 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -12.04 -0.55 5.8e-28 Colorectal cancer; LUSC cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.54 9.14 0.45 6.15e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.65e-8 Depression; LUSC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg11752832 chr7:134001865 SLC35B4 0.55 8.66 0.43 2.09e-16 Mean platelet volume; LUSC trans rs9467711 0.591 rs16891235 chr6:26017542 T/C cg27350398 chr10:3214550 PITRM1 -0.65 -6.01 -0.31 4.86e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4974559 0.739 rs4333131 chr4:1323789 A/G cg02980000 chr4:1222292 CTBP1 0.85 9.71 0.47 8.27e-20 Systolic blood pressure; LUSC cis rs3806843 1.000 rs6870764 chr5:140171790 C/T cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.43e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs12545109 0.800 rs2670028 chr8:57423673 G/A cg09654669 chr8:57350985 NA -0.51 -6.76 -0.35 6.09e-11 Obesity-related traits; LUSC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg17330251 chr7:94953956 PON1 -0.37 -5.96 -0.31 6.32e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs12594515 1.000 rs7172161 chr15:45990780 A/G cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC trans rs1941687 0.797 rs9963397 chr18:31395015 A/T cg27147174 chr7:100797783 AP1S1 -0.44 -6.46 -0.33 3.71e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7633857 0.512 rs733948 chr3:160652784 C/G cg03342759 chr3:160939853 NMD3 -0.41 -6.3 -0.33 9.23e-10 Educational attainment (years of education); LUSC cis rs899997 1.000 rs11072800 chr15:79045857 C/T cg04896959 chr15:78267971 NA -0.48 -10.07 -0.48 5.18e-21 Coronary artery disease or large artery stroke; LUSC cis rs357618 1.000 rs357620 chr5:150847121 A/T cg03212797 chr5:150827313 SLC36A1 -0.4 -5.92 -0.31 7.85e-9 Basophil percentage of white cells; LUSC cis rs56390833 1 rs56390833 chr15:78877381 C/A cg18825076 chr15:78729989 IREB2 -0.5 -7.79 -0.39 8.76e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs3862435 0.572 rs2601167 chr15:90912567 G/A cg22089800 chr15:90895588 ZNF774 0.55 5.85 0.31 1.14e-8 Response to exercise (triglyceride level interaction); LUSC cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg08807101 chr21:30365312 RNF160 -0.79 -14.6 -0.62 1.15e-37 Dental caries; LUSC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg16405210 chr4:1374714 KIAA1530 -0.53 -8.02 -0.4 1.84e-14 Obesity-related traits; LUSC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.38 0.67 1.11e-44 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1348850 0.574 rs4893834 chr2:178442288 C/T cg22681709 chr2:178499509 PDE11A 0.37 5.72 0.3 2.4e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2832077 0.943 rs2832084 chr21:30154798 A/G cg08807101 chr21:30365312 RNF160 -0.52 -6.54 -0.34 2.3e-10 Cognitive test performance; LUSC cis rs7903847 0.619 rs10786336 chr10:99134953 A/C cg20016023 chr10:99160130 RRP12 -0.34 -8.41 -0.42 1.2e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs11758351 0.660 rs6918339 chr6:26211780 G/C cg01420254 chr6:26195488 NA 0.47 5.93 0.31 7.59e-9 Gout;Renal underexcretion gout; LUSC cis rs80282103 0.867 rs11819178 chr10:1098417 A/G cg18964960 chr10:1102726 WDR37 0.71 6.49 0.33 3.04e-10 Glomerular filtration rate (creatinine); LUSC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.13 15.37 0.64 1.05e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs738322 0.600 rs6001031 chr22:38556260 G/T cg17652424 chr22:38574118 PLA2G6 0.28 5.88 0.31 1.02e-8 Cutaneous nevi; LUSC cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs11676855 1.000 rs6710499 chr2:235898590 A/G cg14917874 chr2:235941519 SH3BP4 0.5 8.16 0.41 7.05e-15 Dialysis-related mortality; LUSC trans rs8072100 0.935 rs78737171 chr17:45668760 A/T cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.18e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13997140 chr7:86849809 C7orf23 -0.45 -6.85 -0.35 3.49e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 13.5 0.59 1.97e-33 Platelet count; LUSC cis rs4595586 0.525 rs17467376 chr12:39377551 T/G cg26384229 chr12:38710491 ALG10B 0.52 7.36 0.37 1.42e-12 Morning vs. evening chronotype; LUSC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg21782813 chr7:2030301 MAD1L1 0.59 10.38 0.49 4.56e-22 Bipolar disorder and schizophrenia; LUSC cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.77 -0.43 9.15e-17 Monocyte percentage of white cells; LUSC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg16743903 chr16:89593216 SPG7 0.43 6.03 0.31 4.34e-9 Multiple myeloma (IgH translocation); LUSC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg07936489 chr17:37558343 FBXL20 -0.71 -9.75 -0.47 6.18e-20 Glomerular filtration rate (creatinine); LUSC cis rs34779708 0.931 rs35317849 chr10:35285721 C/A cg03585969 chr10:35415529 CREM 0.64 9.13 0.45 6.65e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg11279151 chr3:101281821 RG9MTD1 -0.47 -7.34 -0.37 1.59e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9549260 0.564 rs7998086 chr13:41268924 T/C cg21288729 chr13:41239152 FOXO1 0.53 7.97 0.4 2.6e-14 Red blood cell count; LUSC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg20203395 chr5:56204925 C5orf35 0.47 7.17 0.37 4.98e-12 Coronary artery disease; LUSC cis rs834603 0.575 rs834597 chr7:47464488 A/T cg09696706 chr7:47479511 TNS3 0.32 5.73 0.3 2.24e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC trans rs2679649 1.000 rs2684271 chr6:122352137 G/A cg00167820 chr8:131663355 NA 0.54 6.35 0.33 6.96e-10 Subcutaneous adipose tissue; LUSC cis rs7180079 1.000 rs1117087 chr15:64598823 T/G cg08069370 chr15:64387884 SNX1 0.54 5.71 0.3 2.44e-8 Monocyte count; LUSC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg18402987 chr7:1209562 NA 0.55 6.07 0.32 3.45e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg15790184 chr11:494944 RNH1 0.59 6.42 0.33 4.77e-10 Body mass index; LUSC cis rs858239 0.600 rs10235786 chr7:23139940 T/C cg05407003 chr7:23246146 NA -0.39 -5.73 -0.3 2.3e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7833790 0.777 rs10958042 chr8:82678393 G/T cg17211192 chr8:82754475 SNX16 -0.76 -10.04 -0.48 6.74e-21 Diastolic blood pressure; LUSC cis rs4663866 1.000 rs4663865 chr2:239145960 C/T cg16914508 chr2:239161102 PER2 -0.63 -6.96 -0.36 1.8e-11 Irritable bowel syndrome; LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg25767906 chr1:53392781 SCP2 0.48 8.58 0.42 3.71e-16 Monocyte count; LUSC cis rs16949788 1.000 rs74894249 chr15:66818647 G/T cg08120210 chr15:66682733 MAP2K1 -0.57 -5.92 -0.31 7.82e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2742417 0.603 rs2064063 chr3:45759924 T/A cg10512202 chr3:45649293 LIMD1 0.36 6.04 0.31 4.18e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg24503407 chr1:205819492 PM20D1 -0.79 -15.53 -0.65 2.45e-41 Monocyte percentage of white cells; LUSC cis rs7267979 1.000 rs11100 chr20:25281184 G/C cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2404618 0.534 rs2214861 chr8:1490604 A/G cg13402656 chr8:1511478 DLGAP2 -0.73 -12.97 -0.58 1.9e-31 Lung cancer; LUSC cis rs3755132 0.929 rs3815689 chr2:15742310 G/T cg12888861 chr2:15731646 DDX1 -0.51 -7.47 -0.38 7.04e-13 Wilms tumor; LUSC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg16405210 chr4:1374714 KIAA1530 -0.57 -8.9 -0.44 3.74e-17 Longevity; LUSC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg19920283 chr7:105172520 RINT1 0.58 6.21 0.32 1.61e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg20608306 chr11:116969690 SIK3 0.37 6.09 0.32 3.1e-9 Blood protein levels; LUSC cis rs12549902 0.966 rs4737000 chr8:41509727 A/C cg21772509 chr8:41503840 NKX6-3 0.67 11.26 0.52 3.89e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs2742417 1.000 rs2742437 chr3:45743277 G/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.48 -0.38 6.61e-13 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs1005277 0.522 rs9417256 chr10:37976990 A/G cg17830980 chr10:43048298 ZNF37B -0.39 -6.23 -0.32 1.4e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6500395 1.000 rs8059905 chr16:48629934 C/T cg04672837 chr16:48644449 N4BP1 0.53 7.95 0.4 2.87e-14 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs10511400 0.850 rs902790 chr3:119886776 A/T cg02809009 chr19:50354510 PTOV1 -0.68 -6.58 -0.34 1.84e-10 Economic and political preferences (feminism/equality); LUSC cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 8.46 0.42 8.29e-16 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7020830 0.894 rs28766572 chr9:37093872 G/T cg14294708 chr9:37120828 ZCCHC7 1.09 24.11 0.8 4.1e-75 Schizophrenia; LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg14004847 chr7:1930337 MAD1L1 -0.55 -8.27 -0.41 3.16e-15 Bipolar disorder and schizophrenia; LUSC cis rs7100689 0.622 rs1340373 chr10:82129250 G/A cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs9399135 0.967 rs6923827 chr6:135335382 C/T cg22676075 chr6:135203613 NA 0.49 7.63 0.39 2.49e-13 Red blood cell count; LUSC trans rs7746199 0.736 rs34573979 chr6:27480526 C/T cg01620082 chr3:125678407 NA -0.78 -7.2 -0.37 4.02e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg24675056 chr1:15929824 NA 0.47 8.06 0.4 1.41e-14 Systolic blood pressure; LUSC cis rs9303401 0.614 rs17175663 chr17:57108437 G/C cg25039879 chr17:56429692 SUPT4H1 0.68 8.86 0.44 5e-17 Cognitive test performance; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg06873352 chr17:61820015 STRADA 0.68 12.3 0.56 6.15e-29 Prudent dietary pattern; LUSC cis rs11030122 0.702 rs10767715 chr11:3951409 G/T cg18678763 chr11:4115507 RRM1 -0.45 -5.82 -0.3 1.34e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg08508325 chr11:3079039 CARS -0.47 -11.14 -0.52 1.03e-24 Longevity; LUSC cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg25817165 chr18:72167213 CNDP2 -0.72 -8.41 -0.42 1.19e-15 Refractive error; LUSC cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg08917208 chr2:24149416 ATAD2B 0.53 5.97 0.31 6e-9 Lymphocyte counts; LUSC cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg06784218 chr1:46089804 CCDC17 -0.47 -9.14 -0.45 6.34e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg01919652 chr6:150259930 NA 0.39 6.45 0.33 3.99e-10 Metabolite levels (Pyroglutamine); LUSC cis rs11792861 0.926 rs72607173 chr9:111879398 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.99 0.44 1.91e-17 Menarche (age at onset); LUSC trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg06636001 chr8:8085503 FLJ10661 0.57 8.73 0.43 1.27e-16 Retinal vascular caliber; LUSC cis rs1448094 0.872 rs7314272 chr12:86401005 T/C cg02569458 chr12:86230093 RASSF9 0.4 6.53 0.34 2.48e-10 Major depressive disorder; LUSC cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg05294307 chr14:35346193 BAZ1A -0.61 -7.38 -0.37 1.23e-12 Psoriasis; LUSC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg19628046 chr18:33552617 C18orf21 0.52 6.26 0.32 1.15e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg06108461 chr20:60628389 TAF4 -0.96 -16.07 -0.66 1.98e-43 Body mass index; LUSC cis rs9457247 0.967 rs86755 chr6:167403108 T/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg06544989 chr22:39130855 UNC84B -0.35 -6.34 -0.33 7.24e-10 Menopause (age at onset); LUSC cis rs7267979 0.966 rs6050567 chr20:25354561 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.83 -0.74 2.23e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg20848291 chr7:100343083 ZAN 0.38 5.88 0.31 1.02e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg21724239 chr8:58056113 NA 0.78 9.78 0.47 5.05e-20 Developmental language disorder (linguistic errors); LUSC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg02038168 chr22:39784481 NA -0.5 -8.16 -0.41 6.77e-15 Intelligence (multi-trait analysis); LUSC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg11812906 chr14:75593930 NEK9 0.66 11.4 0.53 1.24e-25 Height; LUSC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg20203395 chr5:56204925 C5orf35 0.49 7.32 0.37 1.88e-12 Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05920998 chr6:656504 HUS1B;EXOC2 -0.76 -6.09 -0.32 3.02e-9 Cognitive performance; LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -16.92 -0.68 7.95e-47 Gut microbiome composition (summer); LUSC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg05802129 chr4:122689817 NA -0.37 -6.56 -0.34 2.03e-10 Type 2 diabetes; LUSC cis rs6547741 1.000 rs4666007 chr2:27856495 T/C cg12559939 chr2:27858050 GPN1 0.41 6.33 0.33 8.01e-10 Oral cavity cancer; LUSC cis rs11676348 0.846 rs4674259 chr2:218991005 C/T cg06547715 chr2:218990976 CXCR2 0.34 6.44 0.33 4.21e-10 Ulcerative colitis; LUSC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg21963583 chr11:68658836 MRPL21 0.55 8.44 0.42 9.5e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs74338693 0.778 rs3749030 chr2:166774101 T/C cg07963046 chr1:155764892 GON4L 0.47 6.01 0.31 4.97e-9 Schizophrenia; LUSC trans rs11039798 0.920 rs11500574 chr11:48713986 A/T cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg13939156 chr17:80058883 NA -0.33 -6.47 -0.33 3.58e-10 Life satisfaction; LUSC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg19920283 chr7:105172520 RINT1 0.58 6.21 0.32 1.61e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1784581 0.674 rs1789989 chr6:162408138 C/T cg17173639 chr6:162384350 PARK2 0.61 11.22 0.52 5.43e-25 Itch intensity from mosquito bite; LUSC trans rs7824557 0.628 rs11991153 chr8:11203107 A/T cg06636001 chr8:8085503 FLJ10661 0.45 6.48 0.33 3.22e-10 Retinal vascular caliber; LUSC cis rs96067 0.805 rs2296268 chr1:36603165 G/A cg24686825 chr1:36642396 MAP7D1 -0.43 -6.03 -0.31 4.28e-9 Corneal structure; LUSC cis rs9534288 0.742 rs1022953 chr13:46649126 G/T cg15192986 chr13:46630673 CPB2 -0.78 -11.49 -0.53 5.76e-26 Blood protein levels; LUSC cis rs861020 0.677 rs2049998 chr1:210031154 C/T cg09163369 chr1:210001066 C1orf107 -0.54 -6.13 -0.32 2.49e-9 Orofacial clefts; LUSC cis rs7000551 0.556 rs35359294 chr8:22249755 G/A cg12081754 chr8:22256438 SLC39A14 0.99 16.07 0.66 1.97e-43 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7267979 0.966 rs2227890 chr20:25260931 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.74 0.75 5.32e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs929354 0.772 rs1002389 chr7:156968323 C/G cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs7119038 0.774 rs11217037 chr11:118677086 G/A cg19308663 chr11:118741387 NA 0.36 6.34 0.33 7.29e-10 Sjögren's syndrome; LUSC cis rs17539620 0.624 rs12665520 chr6:154835273 C/T cg20019720 chr6:154832845 CNKSR3 0.6 8.6 0.43 3.17e-16 Lipoprotein (a) levels; LUSC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg03806693 chr22:41940476 POLR3H 0.99 14.12 0.61 8.14e-36 Vitiligo; LUSC cis rs11190604 1.000 rs4917901 chr10:102201773 A/C cg07080220 chr10:102295463 HIF1AN 0.65 8.72 0.43 1.3e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 9.91e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg04539111 chr16:67997858 SLC12A4 -0.46 -6.28 -0.33 1.04e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg01017244 chr2:74357527 NA 0.72 14.33 0.62 1.24e-36 Gestational age at birth (maternal effect); LUSC cis rs7570971 0.517 rs10187402 chr2:135771974 C/G cg07169764 chr2:136633963 MCM6 0.53 7.0 0.36 1.41e-11 Blood metabolite levels;Body mass index;Cholesterol, total; LUSC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg12311346 chr5:56204834 C5orf35 -0.68 -10.63 -0.5 6.4e-23 Coronary artery disease; LUSC cis rs7824557 0.564 rs13268126 chr8:11230574 G/A cg21775007 chr8:11205619 TDH -0.7 -11.09 -0.52 1.46e-24 Retinal vascular caliber; LUSC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg12609467 chr3:49508289 DAG1 -0.47 -7.23 -0.37 3.25e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1595825 0.838 rs58576043 chr2:198524149 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.34e-10 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07106325 chr12:120740337 SIRT4 0.42 6.34 0.33 7.39e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg14552801 chr7:65878734 NA 0.45 6.37 0.33 6.28e-10 Aortic root size; LUSC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg04871131 chr7:94954202 PON1 -0.35 -5.65 -0.3 3.52e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs477692 0.517 rs871026 chr10:131293145 A/G cg26102564 chr10:131424627 MGMT -0.38 -5.8 -0.3 1.55e-8 Response to temozolomide; LUSC cis rs1461503 0.932 rs10790542 chr11:122838243 C/T cg27398637 chr11:122830231 C11orf63 -0.42 -6.71 -0.34 8.41e-11 Menarche (age at onset); LUSC cis rs6733011 0.500 rs11123754 chr2:99433782 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.52 -6.82 -0.35 4.26e-11 Bipolar disorder; LUSC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9650657 0.737 rs4841436 chr8:10594474 A/C cg27411982 chr8:10470053 RP1L1 0.39 6.23 0.32 1.39e-9 Neuroticism; LUSC trans rs11700980 0.551 rs62222158 chr21:30110372 A/G cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg23711669 chr6:146136114 FBXO30 0.88 16.81 0.68 2.24e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 0.752 rs72780185 chr2:24003967 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC trans rs9929218 0.529 rs11075694 chr16:68730366 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.06 23.7 0.79 1.61e-73 Colorectal cancer; LUSC trans rs6951245 0.872 rs76713558 chr7:1095866 A/G cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg19539972 chr4:7069911 GRPEL1 0.72 8.66 0.43 2.07e-16 Monocyte percentage of white cells; LUSC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg21573476 chr21:45109991 RRP1B -0.36 -5.74 -0.3 2.11e-8 Mean corpuscular volume; LUSC cis rs67072384 0.818 rs2291292 chr11:72467013 C/T cg04827223 chr11:72435913 ARAP1 -0.73 -6.35 -0.33 7.13e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs7236492 0.748 rs7228738 chr18:77231307 C/T cg15644404 chr18:77186268 NFATC1 -0.57 -5.89 -0.31 9.52e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg20135002 chr11:47629003 NA 0.48 7.71 0.39 1.42e-13 Subjective well-being; LUSC cis rs11098499 0.863 rs12498539 chr4:120468370 C/T cg09307838 chr4:120376055 NA 0.76 11.04 0.52 2.31e-24 Corneal astigmatism; LUSC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg06238570 chr21:40685208 BRWD1 -0.44 -6.79 -0.35 5.07e-11 Cognitive function; LUSC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.87 0.68 1.25e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2354432 1.000 rs2354432 chr1:146693229 C/T cg25205988 chr1:146714368 CHD1L 1.06 13.03 0.58 1.14e-31 Mitochondrial DNA levels; LUSC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg12927641 chr6:109611667 NA -0.35 -5.99 -0.31 5.47e-9 Reticulocyte fraction of red cells; LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg20887711 chr4:1340912 KIAA1530 -0.65 -9.98 -0.48 1.02e-20 Obesity-related traits; LUSC cis rs73200209 0.744 rs61936954 chr12:116473408 T/A cg01776926 chr12:116560359 MED13L -0.5 -5.88 -0.31 1.01e-8 Total body bone mineral density; LUSC cis rs4771122 0.596 rs7334690 chr13:28081535 C/T cg22138327 chr13:27999177 GTF3A 0.47 6.98 0.36 1.58e-11 Body mass index; LUSC cis rs9303280 0.806 rs36095411 chr17:38031865 T/G cg20243544 chr17:37824526 PNMT 0.41 5.99 0.31 5.46e-9 Self-reported allergy; LUSC cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg13699009 chr12:122356056 WDR66 -0.48 -7.43 -0.38 9.29e-13 Mean corpuscular volume; LUSC cis rs11030122 0.702 rs10500590 chr11:3964724 T/C cg18678763 chr11:4115507 RRM1 -0.46 -6.0 -0.31 5.13e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg08470875 chr2:26401718 FAM59B 0.61 8.54 0.42 4.66e-16 Gut microbiome composition (summer); LUSC cis rs9517320 0.534 rs61969451 chr13:99167654 A/T cg20487152 chr13:99095054 FARP1 -0.42 -7.13 -0.36 6.29e-12 Longevity; LUSC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg12639453 chr1:2035780 PRKCZ -0.31 -6.63 -0.34 1.33e-10 Height; LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg08859206 chr1:53392774 SCP2 -0.51 -8.78 -0.43 8.93e-17 Monocyte count; LUSC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs8060686 0.641 rs8058690 chr16:68136622 T/G cg05110241 chr16:68378359 PRMT7 -0.51 -6.12 -0.32 2.69e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs11785400 1.000 rs3735994 chr8:143742683 C/T cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC cis rs2806561 0.929 rs9426694 chr1:23539742 T/C cg19743168 chr1:23544995 NA 0.48 10.44 0.5 2.84e-22 Height; LUSC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg18876405 chr7:65276391 NA -0.54 -8.5 -0.42 6.21e-16 Aortic root size; LUSC cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg03676636 chr4:99064102 C4orf37 0.35 7.67 0.39 1.9e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg08917208 chr2:24149416 ATAD2B 0.56 6.43 0.33 4.43e-10 Lymphocyte counts; LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg20119798 chr7:94954144 PON1 -0.36 -7.09 -0.36 7.93e-12 Paraoxonase activity; LUSC cis rs3857536 0.813 rs62415859 chr6:66934278 G/A cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg27279351 chr12:120934652 DYNLL1 0.57 7.61 0.38 2.76e-13 High light scatter reticulocyte count; LUSC cis rs7771547 0.573 rs9470274 chr6:36397229 G/A cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC cis rs240764 0.604 rs9373590 chr6:101212001 A/T cg09795085 chr6:101329169 ASCC3 0.43 6.1 0.32 2.9e-9 Neuroticism; LUSC cis rs7833986 0.501 rs2953897 chr8:56980569 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.46 0.56 1.61e-29 Height; LUSC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg10802521 chr3:52805072 NEK4 -0.58 -9.45 -0.46 6.09e-19 Electroencephalogram traits; LUSC cis rs2074585 0.806 rs2657949 chr15:90950790 G/A cg22089800 chr15:90895588 ZNF774 0.61 9.12 0.45 6.97e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9811920 0.809 rs923472 chr3:99758029 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 6.0 0.31 5.21e-9 Axial length; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.85 0.54 2.71e-27 Prudent dietary pattern; LUSC cis rs1577917 0.958 rs6454487 chr6:86446868 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.44 0.42 9.69e-16 Response to antipsychotic treatment; LUSC cis rs9311676 0.632 rs6774577 chr3:58361716 A/G cg13750441 chr3:58318267 PXK 0.35 6.75 0.35 6.39e-11 Systemic lupus erythematosus; LUSC cis rs7937682 0.889 rs3017767 chr11:111508098 A/G cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs2932538 0.922 rs4838961 chr1:113163967 T/C cg22162597 chr1:113214053 CAPZA1 -0.69 -9.87 -0.48 2.41e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg12463550 chr7:65579703 CRCP 0.46 6.61 0.34 1.5e-10 Aortic root size; LUSC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg04850211 chr1:228464232 OBSCN 0.32 5.69 0.3 2.81e-8 Diastolic blood pressure; LUSC cis rs9527 0.590 rs10883829 chr10:104840635 T/C cg05855489 chr10:104503620 C10orf26 0.53 7.96 0.4 2.77e-14 Arsenic metabolism; LUSC cis rs951366 0.576 rs1832775 chr1:205734032 C/T cg07157834 chr1:205819609 PM20D1 -0.43 -5.69 -0.3 2.78e-8 Menarche (age at onset); LUSC cis rs12368653 0.666 rs799265 chr12:58112189 A/G cg15848620 chr12:58087721 OS9 -0.4 -5.8 -0.3 1.57e-8 Multiple sclerosis; LUSC cis rs611744 0.647 rs628206 chr8:109247873 A/G cg21045802 chr8:109455806 TTC35 0.42 6.56 0.34 2.04e-10 Dupuytren's disease; LUSC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg07936489 chr17:37558343 FBXL20 -0.71 -10.16 -0.49 2.55e-21 Glomerular filtration rate (creatinine); LUSC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.3 -0.33 9.56e-10 Prostate cancer (SNP x SNP interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26364903 chr2:67624840 ETAA1 0.45 6.43 0.33 4.4e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs34779708 0.931 rs7920095 chr10:35303334 G/A cg03585969 chr10:35415529 CREM 0.64 9.17 0.45 4.82e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg23711669 chr6:146136114 FBXO30 -0.82 -14.71 -0.63 3.97e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs6669072 1.000 rs3845561 chr1:91246342 A/G cg08895590 chr1:91227319 NA 0.36 8.17 0.41 6.37e-15 Cognitive function; LUSC cis rs75920871 0.588 rs4938321 chr11:116852507 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.57 -0.34 1.9e-10 Subjective well-being; LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg13395646 chr4:1353034 KIAA1530 -0.56 -8.02 -0.4 1.78e-14 Longevity; LUSC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg03517284 chr6:25882590 NA 0.39 6.55 0.34 2.13e-10 Intelligence (multi-trait analysis); LUSC cis rs7553864 0.605 rs7531038 chr1:87605049 C/G cg17420885 chr1:87600446 LOC339524 -0.47 -6.53 -0.34 2.38e-10 Smoking behavior; LUSC cis rs9311676 0.656 rs11718352 chr3:58401480 G/A cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs4930561 0.739 rs12225316 chr11:67976003 T/C cg16338278 chr11:67432957 ALDH3B2 0.4 6.75 0.35 6.73e-11 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg19920283 chr7:105172520 RINT1 0.61 6.78 0.35 5.38e-11 Bipolar disorder (body mass index interaction); LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg01238044 chr22:24384105 GSTT1 -0.51 -7.46 -0.38 7.42e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9649213 0.614 rs59120980 chr7:98017730 G/A cg08684580 chr7:98029266 BAIAP2L1 0.39 5.81 0.3 1.42e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs17401966 1.000 rs12757820 chr1:10266671 A/T cg19773385 chr1:10388646 KIF1B -0.51 -8.01 -0.4 1.87e-14 Hepatocellular carcinoma; LUSC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg17143192 chr8:8559678 CLDN23 0.61 8.65 0.43 2.18e-16 Obesity-related traits; LUSC cis rs12681287 0.640 rs12550142 chr8:87471861 C/A cg27223183 chr8:87520930 FAM82B -0.54 -7.45 -0.38 7.92e-13 Caudate activity during reward; LUSC cis rs9815354 0.597 rs17283481 chr3:41924015 T/C cg03022575 chr3:42003672 ULK4 0.83 8.7 0.43 1.48e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg04944784 chr2:26401820 FAM59B -0.68 -9.84 -0.47 3.09e-20 Gut microbiome composition (summer); LUSC cis rs28830936 0.967 rs9672671 chr15:41917075 C/T cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.31 -0.33 8.79e-10 Diastolic blood pressure; LUSC cis rs2708977 0.667 rs772156 chr2:97029830 G/A cg01950434 chr2:97203154 ARID5A -0.46 -6.17 -0.32 2.01e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs7267979 0.565 rs13040726 chr20:25559881 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.63 -0.57 3.54e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs929354 0.742 rs3808316 chr7:156944787 C/G cg05182265 chr7:156933206 UBE3C -0.59 -9.49 -0.46 4.67e-19 Body mass index; LUSC cis rs11166629 1.000 rs4909330 chr8:135644369 T/C cg21672855 chr8:135614777 ZFAT 0.36 5.84 0.3 1.26e-8 Smoking quantity; LUSC cis rs2274273 0.624 rs8014540 chr14:55841688 C/A cg04306507 chr14:55594613 LGALS3 0.48 9.57 0.46 2.41e-19 Protein biomarker; LUSC cis rs4423214 1.000 rs11546509 chr11:71162785 A/G cg05163923 chr11:71159392 DHCR7 0.74 11.04 0.52 2.38e-24 Vitamin D levels; LUSC cis rs738322 0.934 rs133016 chr22:38572582 C/T cg25457927 chr22:38595422 NA -0.42 -8.93 -0.44 2.9e-17 Cutaneous nevi; LUSC cis rs7147624 1.000 rs10135969 chr14:65982345 C/T cg03016385 chr14:66212404 NA -0.85 -9.52 -0.46 3.58e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.54 6.8 0.35 4.85e-11 Renal function-related traits (BUN); LUSC cis rs6546550 0.935 rs10202159 chr2:70062454 G/T cg02498382 chr2:70120550 SNRNP27 -0.29 -7.17 -0.37 4.97e-12 Prevalent atrial fibrillation; LUSC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06061049 chr2:17934875 GEN1;SMC6 0.46 6.31 0.33 9.1e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg11102782 chr19:18549136 ISYNA1 -0.33 -6.19 -0.32 1.74e-9 Breast cancer; LUSC cis rs11048434 0.736 rs35870866 chr12:9129091 C/A cg23795048 chr12:9217529 LOC144571 0.33 5.77 0.3 1.8e-8 Sjögren's syndrome; LUSC cis rs6964587 1.000 rs2075881 chr7:91734552 T/C cg17063962 chr7:91808500 NA 0.56 8.97 0.44 2.15e-17 Breast cancer; LUSC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg11663144 chr21:46675770 NA -0.43 -7.57 -0.38 3.74e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9503598 0.636 rs6596975 chr6:3465925 G/A cg00476032 chr6:3446245 SLC22A23 0.3 5.99 0.31 5.5e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg00800038 chr16:89945340 TCF25 -0.75 -6.56 -0.34 2.08e-10 Skin colour saturation; LUSC cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.12e-11 Height; LUSC cis rs2486288 0.656 rs9920290 chr15:45548035 G/A cg09092052 chr15:45571596 NA 0.46 6.41 0.33 5.09e-10 Glomerular filtration rate; LUSC cis rs113835537 0.559 rs57045447 chr11:66339683 A/G cg24851651 chr11:66362959 CCS 0.58 9.05 0.44 1.21e-17 Airway imaging phenotypes; LUSC trans rs1325195 0.537 rs4651014 chr1:179073039 C/G cg11624085 chr17:8464688 MYH10 -0.44 -6.59 -0.34 1.71e-10 IgE grass sensitization; LUSC cis rs6977660 0.714 rs10257947 chr7:19824099 A/C cg05791153 chr7:19748676 TWISTNB 0.68 7.07 0.36 9.39e-12 Thyroid stimulating hormone; LUSC cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs782590 0.837 rs782585 chr2:55922930 C/T cg03859395 chr2:55845619 SMEK2 0.84 15.01 0.63 2.9e-39 Metabolic syndrome; LUSC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.87 0.31 1.07e-8 Menopause (age at onset); LUSC trans rs4927850 0.666 rs4927853 chr3:195752053 G/C cg16724585 chr3:197361211 NA -0.6 -8.28 -0.41 3.01e-15 Pancreatic cancer; LUSC cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.39 0.46 9.37e-19 Bipolar disorder; LUSC cis rs6740322 0.748 rs13432574 chr2:43544328 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -7.32 -0.37 1.89e-12 Coronary artery disease; LUSC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg18876405 chr7:65276391 NA 0.67 11.49 0.53 5.69e-26 Aortic root size; LUSC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.59 0.6 8.79e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11039798 0.512 rs1988465 chr11:49011303 C/T cg15704280 chr7:45808275 SEPT13 0.76 8.47 0.42 8.13e-16 Axial length; LUSC trans rs877282 0.853 rs7079299 chr10:756455 A/G cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC cis rs317689 0.608 rs650198 chr12:69674595 C/T cg20891283 chr12:69753455 YEATS4 0.45 5.95 0.31 6.83e-9 Response to diuretic therapy; LUSC cis rs1113500 0.933 rs4590700 chr1:108638344 G/T cg06207961 chr1:108661230 NA 0.41 7.55 0.38 4.29e-13 Growth-regulated protein alpha levels; LUSC cis rs8179 0.553 rs42235 chr7:92248076 C/T cg15732164 chr7:92237376 CDK6 -0.39 -5.93 -0.31 7.62e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC trans rs9329221 0.905 rs4610752 chr8:10248962 A/G cg08975724 chr8:8085496 FLJ10661 -0.45 -6.52 -0.34 2.59e-10 Neuroticism; LUSC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs2228479 0.681 rs10153196 chr16:89967397 A/C cg26513180 chr16:89883248 FANCA 0.6 5.69 0.3 2.72e-8 Skin colour saturation; LUSC cis rs7572644 0.766 rs4233720 chr2:28079775 A/G cg27432699 chr2:27873401 GPN1 0.51 6.47 0.33 3.46e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs40363 1.000 rs37767 chr16:3514962 C/T cg21433313 chr16:3507492 NAT15 0.79 9.94 0.48 1.41e-20 Tuberculosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21501234 chr15:64683155 TRIP4 -0.52 -6.47 -0.33 3.48e-10 Bipolar disorder and schizophrenia; LUSC cis rs2795502 1.000 rs2185717 chr10:43343875 G/A cg27426351 chr10:43362370 NA 0.42 5.82 0.3 1.4e-8 Blood protein levels; LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg26338869 chr17:61819248 STRADA 0.41 6.03 0.31 4.42e-9 Prudent dietary pattern; LUSC cis rs79349575 0.749 rs318093 chr17:46989354 A/G cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.39e-13 Type 2 diabetes; LUSC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC trans rs6952808 0.573 rs12668848 chr7:2020995 G/A cg04565464 chr8:145669602 NFKBIL2 0.41 6.89 0.35 2.86e-11 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg16325326 chr1:53192061 ZYG11B -0.9 -16.91 -0.68 9.28e-47 Monocyte count; LUSC cis rs713587 0.563 rs2033655 chr2:25101092 C/T cg01884057 chr2:25150051 NA 0.44 10.05 0.48 6.33e-21 Body mass index in non-asthmatics; LUSC cis rs12908161 1.000 rs12912388 chr15:85344550 T/A cg12863693 chr15:85201151 NMB 0.39 8.1 0.41 1.07e-14 Schizophrenia; LUSC cis rs2991971 1.000 rs2993262 chr1:46013733 G/C cg15605315 chr1:45957053 TESK2 0.46 7.31 0.37 2.04e-12 High light scatter reticulocyte count; LUSC cis rs9469578 0.792 rs73743329 chr6:33713943 T/A cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs7103648 0.966 rs10838702 chr11:47410888 G/T cg20307385 chr11:47447363 PSMC3 0.93 17.54 0.69 2.7e-49 Diastolic blood pressure;Systolic blood pressure; LUSC trans rs3936340 0.607 rs10416064 chr19:48522033 A/G cg11947395 chr12:58088432 OS9 -0.51 -6.06 -0.31 3.75e-9 Intelligence; LUSC cis rs8027181 1.000 rs12900863 chr15:73094671 C/T cg25632853 chr15:73088954 NA 0.34 6.64 0.34 1.24e-10 Triglyceride levels; LUSC cis rs10435719 0.902 rs7006538 chr8:11804982 A/G cg21775007 chr8:11205619 TDH 0.46 6.6 0.34 1.66e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg02269571 chr22:50332266 NA -0.59 -9.17 -0.45 5.12e-18 Schizophrenia; LUSC trans rs7893279 0.822 rs4748465 chr10:18712393 G/A cg01840055 chr3:141338555 NA 0.52 6.33 0.33 7.75e-10 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs13720 0.915 rs163782 chr20:57565943 G/C cg23907860 chr20:57583709 CTSZ -0.43 -5.68 -0.3 2.87e-8 Platelet distribution width; LUSC cis rs8040855 0.542 rs2342122 chr15:85728535 C/G cg04831495 chr15:85060580 GOLGA6L5 0.4 6.54 0.34 2.33e-10 Bulimia nervosa; LUSC cis rs1697139 0.583 rs11960733 chr5:66538715 C/T cg11553311 chr5:66541588 NA 0.33 6.26 0.32 1.21e-9 Breast cancer; LUSC cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.08 20.92 0.75 1.06e-62 Cognitive ability; LUSC cis rs7618501 1.000 rs9859153 chr3:49807085 G/T cg07274523 chr3:49395745 GPX1 -0.36 -5.7 -0.3 2.62e-8 Intelligence (multi-trait analysis); LUSC cis rs12410462 0.581 rs75219436 chr1:227546617 C/T cg10327440 chr1:227177885 CDC42BPA -0.66 -6.47 -0.33 3.44e-10 Major depressive disorder; LUSC cis rs2084898 0.506 rs488672 chr11:120047745 A/G cg07435449 chr11:120005650 TRIM29 -0.38 -6.74 -0.35 6.82e-11 Stroke (pediatric); LUSC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg09359103 chr1:154839909 KCNN3 -0.7 -15.69 -0.65 6.19e-42 Prostate cancer; LUSC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg25072359 chr17:41440525 NA 0.6 8.64 0.43 2.42e-16 Menopause (age at onset); LUSC cis rs2348418 0.831 rs7137119 chr12:28717991 G/T cg13890972 chr12:28721907 NA -0.34 -5.93 -0.31 7.37e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg00990874 chr7:1149470 C7orf50 -0.55 -6.77 -0.35 5.64e-11 Bronchopulmonary dysplasia; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg27094323 chr7:1216898 NA -0.47 -8.22 -0.41 4.6e-15 Longevity;Endometriosis; LUSC cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg19875535 chr5:140030758 IK -0.54 -9.02 -0.44 1.46e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs1358748 0.555 rs2093334 chr1:67536967 G/A cg02640540 chr1:67518911 SLC35D1 0.62 6.52 0.34 2.6e-10 Tuberculosis; LUSC cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg25838465 chr1:92012736 NA 0.48 6.92 0.35 2.37e-11 Eosinophil percentage of white cells; LUSC cis rs2985684 0.841 rs12894785 chr14:50049755 G/C cg04989706 chr14:50066350 PPIL5 -0.48 -6.41 -0.33 4.82e-10 Carotid intima media thickness; LUSC trans rs459571 0.920 rs417142 chr9:136891370 G/T cg10765909 chr12:53715428 AAAS -0.42 -6.06 -0.31 3.64e-9 Platelet distribution width; LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg23758822 chr17:41437982 NA 1.04 20.11 0.74 1.65e-59 Menopause (age at onset); LUSC cis rs1728785 0.681 rs4783649 chr16:68558467 G/A cg02508848 chr16:68573721 ZFP90 0.45 5.73 0.3 2.3e-8 Ulcerative colitis; LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg06600287 chr1:53387719 ECHDC2 -0.3 -6.18 -0.32 1.91e-9 Monocyte count; LUSC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg14416269 chr4:6271139 WFS1 0.53 11.29 0.53 2.9e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg08859206 chr1:53392774 SCP2 -0.68 -12.93 -0.58 2.87e-31 Monocyte count; LUSC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg00800038 chr16:89945340 TCF25 -0.75 -6.56 -0.34 2.08e-10 Skin colour saturation; LUSC cis rs644799 0.601 rs568878 chr11:95578694 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.34 0.53 2.01e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7586879 0.638 rs10203482 chr2:25136916 T/C cg15423357 chr2:25149977 NA 0.45 8.98 0.44 1.98e-17 Body mass index; LUSC cis rs11971779 0.616 rs7779314 chr7:139112696 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg03672933 chr12:100661444 SCYL2;DEPDC4 0.37 5.95 0.31 6.62e-9 Schizophrenia (age at onset); LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.02 -0.36 1.25e-11 Bipolar disorder; LUSC cis rs9807989 0.811 rs11688559 chr2:102969913 C/T cg09003973 chr2:102972529 NA 0.44 6.04 0.31 4.15e-9 Asthma; LUSC cis rs1775715 0.870 rs1775737 chr10:32256871 T/C cg04359828 chr10:32216031 ARHGAP12 0.38 6.25 0.32 1.27e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs61931739 0.817 rs188588 chr12:34215277 G/A cg06521331 chr12:34319734 NA -0.38 -6.55 -0.34 2.15e-10 Morning vs. evening chronotype; LUSC cis rs738322 1.000 rs738320 chr22:38568715 G/T cg17652424 chr22:38574118 PLA2G6 -0.31 -6.71 -0.34 8.58e-11 Cutaneous nevi; LUSC cis rs240764 0.817 rs240113 chr6:101058886 G/A cg09795085 chr6:101329169 ASCC3 0.42 6.14 0.32 2.29e-9 Neuroticism; LUSC cis rs4718428 0.705 rs13220977 chr7:66337648 A/T cg12165864 chr7:66369176 NA 0.52 7.04 0.36 1.11e-11 Corneal structure; LUSC cis rs2479724 0.901 rs2185798 chr6:41773576 G/C cg17623882 chr6:41773611 USP49 0.66 10.98 0.51 3.82e-24 Menarche (age at onset); LUSC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg10802521 chr3:52805072 NEK4 0.45 6.81 0.35 4.43e-11 Bipolar disorder; LUSC cis rs4595586 0.545 rs12809206 chr12:39388748 A/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs7100689 0.646 rs1934693 chr10:82125650 T/C cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs7089973 0.966 rs12772800 chr10:116630962 A/G cg23260525 chr10:116636907 FAM160B1 0.39 7.47 0.38 7.18e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs61931739 0.500 rs73103774 chr12:34482279 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.52 0.65 2.78e-41 Morning vs. evening chronotype; LUSC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg15145296 chr3:125709740 NA -0.56 -6.31 -0.33 8.81e-10 Blood pressure (smoking interaction); LUSC cis rs62400317 0.859 rs62400326 chr6:45287465 T/C cg20913747 chr6:44695427 NA -0.46 -7.44 -0.38 8.4e-13 Total body bone mineral density; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg08088566 chr11:430123 ANO9 0.62 7.18 0.37 4.66e-12 Body mass index; LUSC cis rs9399135 0.933 rs41294852 chr6:135376379 T/G cg22676075 chr6:135203613 NA 0.46 7.23 0.37 3.39e-12 Red blood cell count; LUSC cis rs9811920 0.809 rs4928151 chr3:99767553 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.67 -0.34 1.08e-10 Axial length; LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.11 0.41 9.43e-15 Bipolar disorder; LUSC cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg14530993 chr4:882597 GAK 0.72 7.4 0.38 1.1e-12 Intelligence (multi-trait analysis); LUSC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg10053473 chr17:62856997 LRRC37A3 -0.66 -10.32 -0.49 7.69e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8014204 0.604 rs7156590 chr14:75388183 C/T cg11812906 chr14:75593930 NEK9 0.41 6.21 0.32 1.57e-9 Caffeine consumption; LUSC cis rs11229555 0.609 rs7928676 chr11:58188022 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.59 -0.38 3.26e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs965469 0.545 rs6051846 chr20:3403824 A/G cg25506879 chr20:3388711 C20orf194 0.46 6.03 0.31 4.43e-9 IFN-related cytopenia; LUSC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg04414720 chr1:150670196 GOLPH3L 0.57 8.82 0.43 6.42e-17 Melanoma; LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg10802521 chr3:52805072 NEK4 -0.56 -9.12 -0.45 7.13e-18 Bipolar disorder; LUSC cis rs500891 0.570 rs35606488 chr6:83916502 C/T cg08257003 chr6:84140564 ME1 0.32 6.82 0.35 4.21e-11 Platelet-derived growth factor BB levels; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg26354017 chr1:205819088 PM20D1 0.84 15.08 0.64 1.48e-39 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22416021 chr22:50177941 BRD1 0.41 6.31 0.33 8.94e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs78456975 1.000 rs55761535 chr2:1561450 A/G cg12573674 chr2:1569213 NA -0.55 -6.09 -0.32 3.04e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7909074 1.000 rs6593447 chr10:45400235 G/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.71 -0.43 1.43e-16 Mean corpuscular volume; LUSC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg17747265 chr1:1875780 NA 0.74 17.32 0.69 2.09e-48 Body mass index; LUSC trans rs7939886 0.920 rs1552151 chr11:55780951 A/G cg03929089 chr4:120376271 NA -0.79 -6.81 -0.35 4.59e-11 Myopia (pathological); LUSC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg06212747 chr3:49208901 KLHDC8B 0.48 6.08 0.32 3.33e-9 Parkinson's disease; LUSC cis rs425277 1.000 rs262657 chr1:2088577 G/A cg24578937 chr1:2090814 PRKCZ 0.6 13.6 0.6 7.67e-34 Height; LUSC cis rs12476592 0.602 rs6546019 chr2:63817440 A/G cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.5 0.42 6.34e-16 Colorectal cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03069383 chr2:18741691 RDH14 -0.48 -6.18 -0.32 1.92e-9 Bipolar disorder and schizophrenia; LUSC trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21659725 chr3:3221576 CRBN -0.59 -8.14 -0.41 7.87e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs34779708 0.966 rs12784482 chr10:35446865 A/G cg04310649 chr10:35416472 CREM -0.42 -6.45 -0.33 3.9e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10197940 0.662 rs10173699 chr2:152281561 C/G cg06191203 chr2:152266755 RIF1 0.54 7.28 0.37 2.35e-12 Lung cancer; LUSC trans rs11992162 0.967 rs7836456 chr8:11829175 T/G cg15556689 chr8:8085844 FLJ10661 0.55 8.21 0.41 4.87e-15 Monocyte count; LUSC cis rs11264799 0.603 rs2208753 chr1:157584301 A/C cg18268488 chr1:157545234 FCRL4 0.34 6.32 0.33 8.61e-10 IgA nephropathy; LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg20887711 chr4:1340912 KIAA1530 0.44 6.61 0.34 1.51e-10 Obesity-related traits; LUSC cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg06552810 chr11:31128660 NA 0.41 7.39 0.37 1.17e-12 Red blood cell count; LUSC cis rs2063714 1.000 rs2063714 chr6:157195980 C/G cg23222435 chr6:157204239 ARID1B -0.49 -7.96 -0.4 2.69e-14 Sitting height ratio; LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.03 0.36 1.16e-11 Bipolar disorder; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg26338869 chr17:61819248 STRADA 0.42 6.17 0.32 1.99e-9 Prudent dietary pattern; LUSC cis rs546131 0.928 rs550313 chr11:34830919 C/T cg06937548 chr11:34938143 PDHX;APIP 0.48 6.6 0.34 1.58e-10 Lung disease severity in cystic fibrosis; LUSC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg13798780 chr7:105162888 PUS7 0.56 6.07 0.32 3.43e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6076065 0.723 rs2424539 chr20:23384904 C/T cg11657817 chr20:23433608 CST11 -0.43 -8.19 -0.41 5.63e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs9398803 0.865 rs1578060 chr6:126712247 G/C cg19875578 chr6:126661172 C6orf173 0.42 6.27 0.32 1.1e-9 Male-pattern baldness; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg05064044 chr6:292385 DUSP22 -0.52 -7.68 -0.39 1.76e-13 Menopause (age at onset); LUSC cis rs7586879 0.828 rs9631062 chr2:25110084 C/T cg01884057 chr2:25150051 NA 0.42 8.78 0.43 8.83e-17 Body mass index; LUSC cis rs3806843 0.518 rs2563310 chr5:140015741 A/G cg19875535 chr5:140030758 IK -0.48 -7.88 -0.4 4.52e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs10927875 0.632 rs6699394 chr1:16145143 C/A cg21385522 chr1:16154831 NA -1.01 -20.23 -0.74 5.68e-60 Dilated cardiomyopathy; LUSC cis rs983392 0.805 rs11230183 chr11:59965725 C/T cg24026212 chr11:59952134 MS4A6A -0.36 -6.2 -0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg24838063 chr12:130822603 PIWIL1 0.69 10.73 0.51 2.84e-23 Menopause (age at onset); LUSC cis rs1538970 1.000 rs4660853 chr1:45849090 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.82 0.3 1.4e-8 Platelet count; LUSC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg22907277 chr7:1156413 C7orf50 0.46 6.82 0.35 4.24e-11 Longevity;Endometriosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24009358 chr15:66797395 ZWILCH;RPL4 -0.42 -6.22 -0.32 1.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg25767906 chr1:53392781 SCP2 -0.5 -9.2 -0.45 4.11e-18 Monocyte count; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg22907277 chr7:1156413 C7orf50 0.6 9.36 0.46 1.22e-18 Longevity;Endometriosis; LUSC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg12560992 chr17:57184187 TRIM37 0.9 17.68 0.7 7.53e-50 Intelligence (multi-trait analysis); LUSC cis rs34638657 0.797 rs7203990 chr16:82185320 A/G cg09439754 chr16:82129088 HSD17B2 -0.4 -6.41 -0.33 5.08e-10 Lung adenocarcinoma; LUSC cis rs72717009 0.825 rs6671753 chr1:161478708 G/A cg23840854 chr1:161414152 NA -0.92 -11.2 -0.52 6.13e-25 Rheumatoid arthritis; LUSC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg22963979 chr7:1858916 MAD1L1 -0.43 -6.38 -0.33 5.83e-10 Schizophrenia; LUSC trans rs800082 0.734 rs1726538 chr3:144248888 A/G cg24215973 chr2:240111563 HDAC4 0.41 6.03 0.31 4.37e-9 Smoking behavior; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg11645453 chr3:52864694 ITIH4 0.32 7.5 0.38 5.87e-13 Electroencephalogram traits; LUSC cis rs7312933 0.567 rs11181399 chr12:42666412 G/A cg17420585 chr12:42539391 GXYLT1 -0.34 -6.49 -0.33 3.06e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6460942 0.915 rs6460907 chr7:12304449 G/A cg06484146 chr7:12443880 VWDE -0.52 -6.29 -0.33 9.98e-10 Coronary artery disease; LUSC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg11871910 chr12:69753446 YEATS4 0.82 14.74 0.63 3.03e-38 Blood protein levels; LUSC trans rs2275620 0.535 rs11188172 chr10:96831207 C/T cg08498836 chr3:149292366 WWTR1 0.35 5.98 0.31 5.75e-9 Gout; LUSC cis rs3892630 0.588 rs12610342 chr19:33250690 C/T cg22980127 chr19:33182716 NUDT19 0.88 12.68 0.57 2.5e-30 Red blood cell traits; LUSC cis rs7089973 0.604 rs7920216 chr10:116611794 G/A cg25233709 chr10:116636983 FAM160B1 0.38 6.72 0.35 7.92e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.56 7.84 0.39 6.1e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.08 0.58 7.83e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6495122 0.501 rs6495151 chr15:75385990 A/G cg14664628 chr15:75095509 CSK 0.44 6.38 0.33 6.06e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg03934478 chr11:495069 RNH1 0.77 9.35 0.46 1.27e-18 Body mass index; LUSC cis rs909341 0.710 rs6011016 chr20:62302650 C/G cg16989086 chr20:62203971 PRIC285 -0.54 -7.42 -0.38 9.94e-13 Atopic dermatitis; LUSC cis rs806215 1.000 rs712704 chr7:127258208 A/G cg25922125 chr7:127225783 GCC1 -0.6 -7.44 -0.38 8.65e-13 Type 2 diabetes; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg14196790 chr5:131705035 SLC22A5 0.36 6.0 0.31 5.02e-9 Blood metabolite levels; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg09375034 chr10:5437414 TUBAL3 -0.34 -6.04 -0.31 4.17e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg24130564 chr14:104152367 KLC1 -0.47 -6.88 -0.35 2.99e-11 Intelligence (multi-trait analysis); LUSC cis rs10484885 0.878 rs111664889 chr6:90566427 G/T cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.31 -0.41 2.35e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs72901758 0.696 rs72909029 chr17:76249451 A/G cg25512537 chr17:76250053 NA 0.51 8.8 0.43 7.57e-17 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg20573242 chr4:122745356 CCNA2 0.64 9.47 0.46 5.31e-19 Type 2 diabetes; LUSC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg23172400 chr8:95962367 TP53INP1 -0.38 -7.65 -0.39 2.2e-13 Type 2 diabetes; LUSC trans rs7615952 0.736 rs13063122 chr3:125643860 G/A cg07211511 chr3:129823064 LOC729375 -1.22 -20.76 -0.75 4.52e-62 Blood pressure (smoking interaction); LUSC cis rs654950 0.783 rs640688 chr1:42001831 A/G cg06885757 chr1:42089581 HIVEP3 -0.34 -6.49 -0.33 3.15e-10 Airway imaging phenotypes; LUSC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.69e-9 Systolic blood pressure; LUSC cis rs4629710 0.568 rs9492880 chr6:131565962 G/T cg12606694 chr6:131520996 AKAP7 0.6 9.09 0.45 9.02e-18 Multiple myeloma (IgH translocation); LUSC trans rs7824557 0.815 rs958648 chr8:11103895 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.67 -0.39 1.92e-13 Retinal vascular caliber; LUSC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg02038168 chr22:39784481 NA -0.43 -6.39 -0.33 5.62e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg01000954 chr5:140821244 PCDHGA4;PCDHGA12;PCDHGA11;PCDHGA9;PCDHGA1;PCDHGB1;PCDHGB6;PCDHGB3;PCDHGB7;PCDHGA6;PCDHGA8;PCDHGA10;PCDHGA5;PCDHGB4;PCDHGA3;PCDHGA2;PCDHGB2;PCDHGA7;PCDHGB5 -0.42 -6.1 -0.32 2.9e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs6547741 0.788 rs7595739 chr2:27874563 G/T cg12559939 chr2:27858050 GPN1 -0.39 -6.03 -0.31 4.25e-9 Oral cavity cancer; LUSC cis rs826838 1.000 rs11183160 chr12:38676702 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.89 0.51 7.65e-24 Heart rate; LUSC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08109568 chr15:31115862 NA 0.62 9.48 0.46 5.06e-19 Huntington's disease progression; LUSC cis rs9902453 0.726 rs4795523 chr17:28176314 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.26 0.52 3.81e-25 Coffee consumption (cups per day); LUSC cis rs9790314 1.000 rs7653361 chr3:160992291 C/T cg03342759 chr3:160939853 NMD3 -0.51 -8.5 -0.42 6.58e-16 Morning vs. evening chronotype; LUSC cis rs644799 0.672 rs11021347 chr11:95653494 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.72 10.17 0.49 2.38e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg26408565 chr15:76604113 ETFA 0.52 8.18 0.41 6.17e-15 Blood metabolite levels; LUSC cis rs4478137 0.839 rs3967763 chr4:164239273 G/C cg06758707 chr4:164254230 NPY1R 0.63 9.8 0.47 4.14e-20 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.45 0.33 3.87e-10 Schizophrenia; LUSC cis rs7267979 1.000 rs6050555 chr20:25328543 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.26 -0.32 1.21e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2274273 0.588 rs58296156 chr14:55828327 C/T cg04306507 chr14:55594613 LGALS3 0.49 9.82 0.47 3.79e-20 Protein biomarker; LUSC cis rs10979 1.000 rs9376763 chr6:143887386 C/T cg25407410 chr6:143891975 LOC285740 -0.74 -12.01 -0.55 7.28e-28 Hypospadias; LUSC cis rs11098499 0.909 rs7659501 chr4:120371552 G/T cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs10927875 0.501 rs61782229 chr1:16220118 G/A cg21385522 chr1:16154831 NA -0.87 -12.45 -0.56 1.7e-29 Dilated cardiomyopathy; LUSC cis rs2625529 0.775 rs4777484 chr15:72376543 T/C cg16672083 chr15:72433130 SENP8 -0.52 -7.59 -0.38 3.22e-13 Red blood cell count; LUSC cis rs75804782 0.641 rs72985387 chr2:239336589 G/A cg18131467 chr2:239335373 ASB1 -0.72 -6.54 -0.34 2.25e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg19592336 chr6:28129416 ZNF389 0.46 6.37 0.33 6.12e-10 Parkinson's disease; LUSC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg24733560 chr20:60626293 TAF4 0.43 7.99 0.4 2.16e-14 Body mass index; LUSC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg26754761 chr2:177040938 NA -0.39 -7.66 -0.39 2.09e-13 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs12681288 0.754 rs4735975 chr8:1000470 T/C cg04851639 chr8:1020857 NA -0.37 -7.9 -0.4 4.19e-14 Schizophrenia; LUSC cis rs62400317 0.787 rs10456547 chr6:45219526 T/C cg18551225 chr6:44695536 NA -0.43 -6.93 -0.35 2.11e-11 Total body bone mineral density; LUSC trans rs1005277 0.505 rs7099777 chr10:38183569 A/C cg17830980 chr10:43048298 ZNF37B 0.42 6.62 0.34 1.47e-10 Extrinsic epigenetic age acceleration; LUSC trans rs1997103 1.000 rs4948012 chr7:55412578 A/C cg20935933 chr6:143382018 AIG1 0.51 7.38 0.37 1.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.19 0.52 6.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7267979 0.816 rs422148 chr20:25512604 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.74 14.8 0.63 1.89e-38 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg07703079 chr11:430292 ANO9 0.66 6.75 0.35 6.51e-11 Body mass index; LUSC cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg26384229 chr12:38710491 ALG10B 0.85 14.12 0.61 8.34e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg09904177 chr6:26538194 HMGN4 -0.5 -5.82 -0.3 1.38e-8 Intelligence (multi-trait analysis); LUSC cis rs10791097 0.720 rs6590515 chr11:130733365 A/G cg12179176 chr11:130786555 SNX19 -0.74 -11.44 -0.53 8.75e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2073300 1.000 rs6048833 chr20:23462185 G/A cg09953122 chr20:23471693 CST8 -0.76 -7.49 -0.38 6.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg14983838 chr19:29218262 NA 0.65 9.14 0.45 6.14e-18 Methadone dose in opioid dependence; LUSC cis rs977987 0.806 rs35552529 chr16:75405879 G/C cg03315344 chr16:75512273 CHST6 0.48 9.24 0.45 3.06e-18 Dupuytren's disease; LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.06 -0.68 2.25e-47 Gut microbiome composition (summer); LUSC cis rs9815354 0.638 rs17218866 chr3:42017634 T/C cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03352830 chr11:487213 PTDSS2 -0.72 -9.16 -0.45 5.55e-18 Body mass index; LUSC cis rs7608623 0.742 rs6756280 chr2:23921055 A/G cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC cis rs981844 0.712 rs62325150 chr4:154728117 T/G cg14289246 chr4:154710475 SFRP2 0.44 5.91 0.31 8.36e-9 Response to statins (LDL cholesterol change); LUSC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.78e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7620457 1.000 rs7620457 chr3:183747266 A/G cg01324343 chr3:183735012 ABCC5 -0.59 -9.26 -0.45 2.53e-18 Body mass index; LUSC cis rs1577917 1.000 rs2166663 chr6:86593896 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.34 -0.42 2.03e-15 Response to antipsychotic treatment; LUSC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg00990874 chr7:1149470 C7orf50 -0.58 -7.51 -0.38 5.41e-13 Bronchopulmonary dysplasia; LUSC cis rs1595825 0.891 rs79845692 chr2:198523541 T/C cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.34e-10 Ulcerative colitis; LUSC cis rs524023 0.914 rs526338 chr11:64418900 G/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.48 -0.5 2.08e-22 Urate levels in obese individuals; LUSC cis rs8017423 0.967 rs11159957 chr14:90715972 A/G cg04374321 chr14:90722782 PSMC1 -0.75 -12.14 -0.55 2.35e-28 Mortality in heart failure; LUSC cis rs72634258 0.519 rs2071984 chr1:7928656 C/T cg00042356 chr1:8021962 PARK7 0.61 7.21 0.37 3.75e-12 Inflammatory bowel disease; LUSC cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.5 0.65 3.4e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs7937682 0.855 rs571462 chr11:111487106 C/G cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs3096299 0.746 rs9931120 chr16:89501357 A/G cg00750074 chr16:89608354 SPG7 -0.54 -9.48 -0.46 5e-19 Multiple myeloma (IgH translocation); LUSC cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg13010199 chr12:38710504 ALG10B 0.7 11.4 0.53 1.18e-25 Heart rate; LUSC trans rs11949289 1.000 rs6884749 chr5:28338714 T/C cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.55e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs3741151 0.892 rs7102787 chr11:73012614 A/G cg17517138 chr11:73019481 ARHGEF17 0.92 8.39 0.42 1.44e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7666738 0.546 rs10018080 chr4:98758436 C/A cg03676636 chr4:99064102 C4orf37 0.3 5.96 0.31 6.52e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.774 rs2247571 chr6:146219533 T/A cg23711669 chr6:146136114 FBXO30 0.8 13.9 0.61 5.63e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg12463550 chr7:65579703 CRCP -0.51 -7.45 -0.38 7.92e-13 Aortic root size; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg17372223 chr3:52568218 NT5DC2 0.4 6.33 0.33 7.71e-10 Electroencephalogram traits; LUSC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg06618935 chr21:46677482 NA -0.38 -7.57 -0.38 3.79e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs977987 0.806 rs35683383 chr16:75479277 G/T cg04384234 chr16:75411784 CFDP1 -0.42 -7.03 -0.36 1.14e-11 Dupuytren's disease; LUSC cis rs500891 0.500 rs62421760 chr6:83915335 T/C cg08257003 chr6:84140564 ME1 0.3 6.34 0.33 7.52e-10 Platelet-derived growth factor BB levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23719950 chr11:63933701 MACROD1 -0.47 -6.3 -0.33 9.13e-10 Bipolar disorder and schizophrenia; LUSC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg22571038 chr17:48585470 MYCBPAP -0.56 -7.91 -0.4 3.9e-14 Visceral fat; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.77e-16 Developmental language disorder (linguistic errors); LUSC cis rs4911259 0.552 rs13038881 chr20:31468113 T/C cg13636640 chr20:31349939 DNMT3B -0.81 -15.77 -0.65 2.8e-42 Inflammatory bowel disease; LUSC cis rs1185460 0.967 rs1786141 chr11:118938315 C/T cg01677386 chr11:118938358 VPS11 -0.49 -6.83 -0.35 3.91e-11 Coronary artery disease; LUSC cis rs7223966 1.000 rs56057198 chr17:61733332 G/A cg05941027 chr17:61774174 LIMD2 0.24 6.12 0.32 2.7e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg21665744 chr7:39171113 POU6F2 0.49 7.78 0.39 8.99e-14 IgG glycosylation; LUSC cis rs7582180 0.629 rs11685406 chr2:100946638 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs9733 0.650 rs12406712 chr1:150545084 C/A cg04414720 chr1:150670196 GOLPH3L -0.45 -6.92 -0.35 2.31e-11 Tonsillectomy; LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg06877462 chr1:205807181 PM20D1 0.39 7.38 0.37 1.25e-12 Menarche (age at onset); LUSC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.12 17.39 0.69 1.06e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg05896524 chr21:47604654 C21orf56 0.53 8.26 0.41 3.46e-15 Testicular germ cell tumor; LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg00431813 chr7:1051703 C7orf50 -0.43 -6.95 -0.36 1.9e-11 Longevity;Endometriosis; LUSC cis rs4285028 0.747 rs3732410 chr3:121415720 T/C cg11130432 chr3:121712080 ILDR1 -0.53 -7.75 -0.39 1.12e-13 Multiple sclerosis; LUSC cis rs12893668 0.667 rs8017628 chr14:104047428 C/T cg08213375 chr14:104286397 PPP1R13B 0.35 5.92 0.31 8.09e-9 Reticulocyte count; LUSC cis rs2637266 0.714 rs7082421 chr10:78446313 G/A cg18941641 chr10:78392320 NA 0.33 5.88 0.31 9.83e-9 Pulmonary function; LUSC cis rs9341808 0.591 rs7741013 chr6:80916330 G/A cg08355045 chr6:80787529 NA 0.46 7.97 0.4 2.62e-14 Sitting height ratio; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg10819733 chr22:24237672 NA -0.38 -5.73 -0.3 2.21e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12208915 0.848 rs77415956 chr6:79514757 G/A cg05283184 chr6:79620031 NA 0.42 5.67 0.3 3.09e-8 Left atrial antero-posterior diameter; LUSC cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs2377585 0.563 rs10842109 chr12:8841077 G/A cg03761649 chr12:8850719 RIMKLB 0.47 6.05 0.31 3.94e-9 Reticulocyte fraction of red cells; LUSC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs1448094 0.617 rs10863162 chr12:86474122 C/T cg00310523 chr12:86230176 RASSF9 -0.33 -5.97 -0.31 5.98e-9 Major depressive disorder; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg27535305 chr1:53392650 SCP2 0.53 10.2 0.49 1.95e-21 Monocyte count; LUSC cis rs6121246 0.567 rs6060261 chr20:30192948 C/G cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg21545522 chr1:205238299 TMCC2 0.49 9.2 0.45 3.93e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2479724 0.636 rs2265139 chr6:41819407 C/G cg17623882 chr6:41773611 USP49 -0.55 -7.61 -0.38 2.78e-13 Menarche (age at onset); LUSC cis rs612683 0.524 rs584350 chr1:100908324 A/G cg06223162 chr1:101003688 GPR88 0.42 7.74 0.39 1.23e-13 Breast cancer; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg00684032 chr4:1343700 KIAA1530 0.35 6.36 0.33 6.72e-10 Obesity-related traits; LUSC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg22590775 chr19:49891494 CCDC155 0.5 6.73 0.35 7.24e-11 Multiple sclerosis; LUSC cis rs12891047 0.866 rs181570 chr14:68275342 A/G cg20999565 chr14:68265668 ZFYVE26 0.37 5.67 0.3 3.04e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg03806693 chr22:41940476 POLR3H -1.03 -14.79 -0.63 2.09e-38 Vitiligo; LUSC trans rs2229238 0.866 rs112231452 chr1:154504900 G/A cg25273160 chr11:56955011 LRRC55 0.31 6.05 0.31 3.94e-9 Coronary heart disease; LUSC cis rs5758511 0.731 rs12158579 chr22:42351289 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.46 -5.73 -0.3 2.21e-8 Birth weight; LUSC trans rs7647973 0.626 rs62260720 chr3:49853796 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.62 7.29 0.37 2.2e-12 Menarche (age at onset); LUSC cis rs6542838 0.582 rs6542845 chr2:99537600 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.52 -0.34 2.64e-10 Fear of minor pain; LUSC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg18876405 chr7:65276391 NA -0.57 -9.18 -0.45 4.69e-18 Aortic root size; LUSC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7538876 0.903 rs6688886 chr1:17753639 G/A cg07965774 chr1:17746286 RCC2 0.31 5.87 0.31 1.06e-8 Basal cell carcinoma; LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg22868518 chr11:507468 RNH1 -0.61 -5.94 -0.31 7.1e-9 Body mass index; LUSC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg21251018 chr6:28226885 NKAPL -0.35 -6.56 -0.34 2.03e-10 Cardiac Troponin-T levels; LUSC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg14664628 chr15:75095509 CSK -0.56 -8.82 -0.43 6.28e-17 Breast cancer; LUSC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.8 -0.3 1.54e-8 Intelligence (multi-trait analysis); LUSC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg24296786 chr1:45957014 TESK2 0.46 6.76 0.35 6.29e-11 High light scatter reticulocyte count; LUSC cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg24642439 chr20:33292090 TP53INP2 0.48 7.16 0.36 5.1e-12 Glomerular filtration rate (creatinine); LUSC cis rs1950500 1.000 rs12590407 chr14:24835115 A/G cg16194253 chr14:24768981 DHRS1;C14orf21 -0.45 -6.19 -0.32 1.74e-9 Height; LUSC trans rs10506458 1.000 rs1009539 chr12:63414655 A/G cg22491629 chr6:157744540 C6orf35 0.79 9.81 0.47 4.05e-20 Hemostatic factors and hematological phenotypes; LUSC cis rs9398803 0.965 rs9388486 chr6:126661154 C/T cg19875578 chr6:126661172 C6orf173 -0.41 -6.01 -0.31 4.93e-9 Male-pattern baldness; LUSC cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg22467129 chr15:76604101 ETFA -0.42 -6.67 -0.34 1.04e-10 Blood metabolite levels; LUSC cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg03146154 chr1:46216737 IPP 0.53 7.71 0.39 1.43e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.06 0.31 3.68e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2455601 0.638 rs2248245 chr11:8988350 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.4 -5.94 -0.31 7.28e-9 Schizophrenia; LUSC cis rs4356932 0.967 rs13111790 chr4:76972402 G/C cg00809888 chr4:76862425 NAAA 0.35 5.86 0.31 1.11e-8 Blood protein levels; LUSC cis rs76419734 0.510 rs6820671 chr4:106613821 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.64 7.85 0.39 5.57e-14 Post bronchodilator FEV1; LUSC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs11677416 1.000 rs3783559 chr2:113529837 A/G cg27083787 chr2:113543245 IL1A 0.46 7.26 0.37 2.77e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg07701084 chr6:150067640 NUP43 0.46 6.97 0.36 1.7e-11 Lung cancer; LUSC cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg06784218 chr1:46089804 CCDC17 -0.47 -8.92 -0.44 3.06e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9399135 0.967 rs6919862 chr6:135352443 C/A cg24558204 chr6:135376177 HBS1L 0.59 9.15 0.45 5.91e-18 Red blood cell count; LUSC cis rs10887741 0.966 rs7085195 chr10:89429897 T/C cg13926569 chr10:89418898 PAPSS2 0.33 6.59 0.34 1.75e-10 Exercise (leisure time); LUSC trans rs9409154 0.617 rs7859870 chr9:118367195 C/T cg06386307 chr6:100895211 SIM1 0.34 6.3 0.33 9.51e-10 Visceral adipose tissue adjusted for BMI; LUSC cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg05347473 chr6:146136440 FBXO30 0.52 8.78 0.43 8.54e-17 Lobe attachment (rater-scored or self-reported); LUSC trans rs6952808 1.000 rs6954521 chr7:1886865 C/A cg24247370 chr13:99142703 STK24 -0.34 -6.17 -0.32 1.96e-9 Bipolar disorder and schizophrenia; LUSC trans rs1922233 0.943 rs1922226 chr4:92413671 A/G cg24250684 chr1:219729030 NA -0.34 -6.47 -0.33 3.57e-10 Gut microbiome composition (summer and winter); LUSC cis rs9287719 0.601 rs12995465 chr2:10716828 G/A cg00105475 chr2:10696890 NA 0.35 5.8 0.3 1.58e-8 Prostate cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09300980 chr6:17601309 FAM8A1 -0.41 -6.21 -0.32 1.56e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7937682 0.889 rs1940529 chr11:111498523 G/C cg09085632 chr11:111637200 PPP2R1B -1.12 -18.16 -0.7 9.73e-52 Primary sclerosing cholangitis; LUSC trans rs11098499 0.754 rs10006259 chr4:120242145 C/T cg25214090 chr10:38739885 LOC399744 0.43 6.58 0.34 1.77e-10 Corneal astigmatism; LUSC cis rs3820928 0.874 rs3769646 chr2:227896330 C/T cg11843606 chr2:227700838 RHBDD1 -0.52 -7.49 -0.38 6.31e-13 Pulmonary function; LUSC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg11859384 chr17:80120422 CCDC57 0.36 5.71 0.3 2.51e-8 Life satisfaction; LUSC cis rs3806843 1.000 rs1030164 chr5:140185272 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs77106637 1.000 rs11602858 chr11:72615069 C/G cg03878208 chr11:72483293 STARD10 0.57 7.35 0.37 1.55e-12 Type 2 diabetes; LUSC cis rs17102423 0.760 rs2781375 chr14:65569597 A/G cg11161011 chr14:65562177 MAX -0.65 -9.85 -0.47 2.93e-20 Obesity-related traits; LUSC cis rs1728785 1.000 rs4783656 chr16:68580722 C/T cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs7246967 0.673 rs12980342 chr19:22849357 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs4478858 0.698 rs6655946 chr1:31805728 G/A cg00250761 chr1:31883323 NA -0.37 -9.16 -0.45 5.22e-18 Alcohol dependence; LUSC cis rs8060686 0.641 rs73612222 chr16:68216072 A/G cg27539214 chr16:67997921 SLC12A4 -0.56 -7.28 -0.37 2.41e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs656319 0.513 rs1484641 chr8:9986524 A/C cg27411982 chr8:10470053 RP1L1 0.41 6.06 0.31 3.68e-9 Myopia (pathological); LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg08470875 chr2:26401718 FAM59B -0.61 -7.55 -0.38 4.21e-13 Gut microbiome composition (summer); LUSC trans rs6952808 0.929 rs12667688 chr7:1931030 C/T cg04565464 chr8:145669602 NFKBIL2 0.4 6.61 0.34 1.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs4853525 0.923 rs4853521 chr2:191730184 G/A cg11845111 chr2:191398756 TMEM194B -0.41 -5.97 -0.31 5.99e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg04414720 chr1:150670196 GOLPH3L 0.52 8.1 0.41 1.06e-14 Melanoma; LUSC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg06634786 chr22:41940651 POLR3H 0.52 6.16 0.32 2.11e-9 Vitiligo; LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.26 0.37 2.8e-12 Platelet count; LUSC cis rs644799 0.664 rs603625 chr11:95554283 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.35 0.59 7.34e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2688608 0.901 rs2459446 chr10:75601596 C/T cg23231163 chr10:75533350 FUT11 0.41 6.53 0.34 2.41e-10 Inflammatory bowel disease; LUSC cis rs7208859 0.623 rs11656844 chr17:29060597 G/T cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs459571 0.959 rs456205 chr9:136911146 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.42 -6.14 -0.32 2.4e-9 Platelet distribution width; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg04234412 chr22:24373322 LOC391322 -0.82 -13.2 -0.59 2.59e-32 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg01689657 chr7:91764605 CYP51A1 0.33 5.98 0.31 5.67e-9 Breast cancer; LUSC cis rs6076065 1.000 rs6076065 chr20:23368411 C/A cg11657817 chr20:23433608 CST11 0.44 8.66 0.43 2.12e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg18681998 chr4:17616180 MED28 0.78 13.71 0.6 3.02e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7954584 0.616 rs10743186 chr12:122356436 C/T cg21171335 chr12:122356390 WDR66 0.54 7.77 0.39 9.57e-14 Mean corpuscular volume; LUSC cis rs6489882 0.867 rs4767032 chr12:113363077 T/G cg20102336 chr12:113376681 OAS3 -0.42 -5.93 -0.31 7.36e-9 Chronic lymphocytic leukemia; LUSC cis rs7824557 0.628 rs11991153 chr8:11203107 A/T cg21775007 chr8:11205619 TDH 0.81 13.68 0.6 3.88e-34 Retinal vascular caliber; LUSC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg23643435 chr2:38893251 GALM -0.67 -6.84 -0.35 3.74e-11 5-HTT brain serotonin transporter levels; LUSC cis rs11250464 0.833 rs11250466 chr10:1409378 C/T cg08668359 chr10:1443807 ADARB2 0.41 6.19 0.32 1.77e-9 Radiation response; LUSC cis rs314370 0.904 rs314373 chr7:100456595 G/A cg08558340 chr7:100472263 SRRT 0.51 6.41 0.33 5e-10 Resting heart rate; LUSC trans rs8073060 0.519 rs8065286 chr17:33864479 A/G cg19694781 chr19:47549865 TMEM160 0.56 8.75 0.43 1.04e-16 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7267979 0.966 rs2261795 chr20:25263136 T/C cg08601574 chr20:25228251 PYGB 0.43 6.65 0.34 1.17e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2439831 0.850 rs28707214 chr15:44131623 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.74 0.35 7.17e-11 Lung cancer in ever smokers; LUSC cis rs7106204 0.764 rs58215218 chr11:24234720 G/T ch.11.24196551F chr11:24239977 NA 1.0 9.11 0.45 7.77e-18 Response to Homoharringtonine (cytotoxicity); LUSC cis rs17433780 0.504 rs6428494 chr1:89472196 C/T cg09516651 chr1:89888402 LOC400759 0.44 7.95 0.4 2.92e-14 Carotid intima media thickness; LUSC cis rs2816062 0.786 rs2745320 chr1:18893592 G/A cg18795169 chr1:18902165 NA -1.0 -24.12 -0.8 3.83e-75 Urate levels in lean individuals; LUSC cis rs9403521 0.898 rs12207002 chr6:143975422 G/A cg18240653 chr6:144019428 PHACTR2 -0.5 -6.07 -0.32 3.51e-9 Obesity-related traits; LUSC cis rs17125944 0.615 rs1886786 chr14:53312189 A/T cg00686598 chr14:53173677 PSMC6 -0.62 -5.85 -0.3 1.17e-8 Alzheimer's disease (late onset); LUSC cis rs8017423 0.967 rs2277514 chr14:90723059 T/C cg04374321 chr14:90722782 PSMC1 0.75 12.08 0.55 4e-28 Mortality in heart failure; LUSC cis rs7103648 0.695 rs12223593 chr11:47789082 T/G cg20307385 chr11:47447363 PSMC3 0.81 12.4 0.56 2.75e-29 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs3008870 1.000 rs2815371 chr1:67504313 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.92 14.54 0.62 1.94e-37 Lymphocyte percentage of white cells; LUSC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg07870213 chr5:140052090 DND1 0.77 11.51 0.53 4.78e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs668210 0.793 rs622779 chr11:65744247 G/A cg04700828 chr11:65773979 NA 0.39 5.66 0.3 3.18e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7937682 0.632 rs11214029 chr11:111761230 C/T cg09085632 chr11:111637200 PPP2R1B 0.89 10.69 0.51 3.75e-23 Primary sclerosing cholangitis; LUSC cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg18681998 chr4:17616180 MED28 0.86 15.71 0.65 4.97e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg27129171 chr3:47204927 SETD2 -0.69 -11.6 -0.54 2.23e-26 Colorectal cancer; LUSC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.4 6.35 0.33 6.88e-10 Cystic fibrosis severity; LUSC trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg15704280 chr7:45808275 SEPT13 0.93 13.42 0.59 3.7e-33 Coronary artery disease; LUSC cis rs3087591 0.960 rs4795593 chr17:29613600 G/C cg24425628 chr17:29625626 OMG;NF1 -0.57 -8.27 -0.41 3.11e-15 Hip circumference; LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg10729496 chr3:10149963 C3orf24 -0.57 -7.92 -0.4 3.63e-14 Alzheimer's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17707966 chr8:144718525 ZNF623 -0.4 -5.98 -0.31 5.69e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC trans rs9291683 0.597 rs11723016 chr4:10126189 A/G cg26043149 chr18:55253948 FECH -0.53 -7.8 -0.39 8.08e-14 Bone mineral density; LUSC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg26028573 chr6:26043587 HIST1H2BB 0.38 5.77 0.3 1.82e-8 Intelligence (multi-trait analysis); LUSC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg06074448 chr4:187884817 NA -0.41 -6.82 -0.35 4.28e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg09904177 chr6:26538194 HMGN4 0.51 6.02 0.31 4.68e-9 Intelligence (multi-trait analysis); LUSC cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg09479241 chr17:27052676 TLCD1 0.43 5.96 0.31 6.29e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs7746199 0.736 rs13195636 chr6:27509493 A/C cg01620082 chr3:125678407 NA -0.77 -7.19 -0.37 4.16e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1055129 0.560 rs2305913 chr17:73922941 T/C cg19302996 chr17:73780495 UNK -0.49 -7.07 -0.36 9.28e-12 White matter hyperintensity burden; LUSC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg07936489 chr17:37558343 FBXL20 0.74 10.22 0.49 1.63e-21 Glomerular filtration rate (creatinine); LUSC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.11 0.32 2.71e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7851660 0.775 rs7034336 chr9:100661100 C/T cg13688889 chr9:100608707 NA -0.54 -8.44 -0.42 9.53e-16 Strep throat; LUSC trans rs9354352 0.818 rs9453548 chr6:66691885 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.59 -8.43 -0.42 1.07e-15 Initial pursuit acceleration in psychotic disorders; LUSC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.575 rs7107213 chr11:111750430 A/G cg19812747 chr11:111475976 SIK2 0.42 5.69 0.3 2.81e-8 Primary sclerosing cholangitis; LUSC cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs9393777 0.778 rs67457459 chr6:27198343 T/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.55 -6.35 -0.33 6.95e-10 Intelligence (multi-trait analysis); LUSC cis rs3092073 0.624 rs3848719 chr20:44596545 G/A cg23303369 chr20:44641161 MMP9 0.39 6.63 0.34 1.33e-10 Intelligence (multi-trait analysis); LUSC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg03396347 chr1:1875803 NA -0.43 -9.19 -0.45 4.15e-18 Body mass index; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg07157834 chr1:205819609 PM20D1 0.54 8.8 0.43 7.55e-17 Menarche (age at onset); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg06837731 chr10:101945906 ERLIN1 0.42 6.03 0.31 4.33e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg06074448 chr4:187884817 NA -0.41 -6.89 -0.35 2.85e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.890 rs11053018 chr12:34105962 T/G cg13010199 chr12:38710504 ALG10B -0.45 -7.04 -0.36 1.1e-11 Morning vs. evening chronotype; LUSC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg14895029 chr7:2775587 GNA12 -0.38 -6.0 -0.31 5.21e-9 Height; LUSC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg25767906 chr1:53392781 SCP2 0.45 7.9 0.4 4e-14 Monocyte count; LUSC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg17264618 chr3:40429014 ENTPD3 0.33 7.1 0.36 7.64e-12 Renal cell carcinoma; LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg11236850 chr4:8443022 ACOX3 0.42 6.33 0.33 7.8e-10 Mosquito bite size; LUSC cis rs7804356 1.000 rs3823934 chr7:26853934 T/C cg03456212 chr7:26904342 SKAP2 -0.54 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs9905704 0.633 rs2680713 chr17:56523900 G/T cg19466818 chr17:56409534 MIR142 -0.35 -6.41 -0.33 4.87e-10 Testicular germ cell tumor; LUSC cis rs1775715 0.737 rs2778650 chr10:32106851 A/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.68e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12681287 0.577 rs11992955 chr8:87530485 A/G cg27223183 chr8:87520930 FAM82B 0.53 6.94 0.36 2.04e-11 Caudate activity during reward; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg07092213 chr7:1199455 ZFAND2A -0.67 -10.97 -0.51 4.17e-24 Longevity;Endometriosis; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.57 0.38 3.61e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs61021925 1 rs61021925 chr12:122863659 T/C cg23029597 chr12:123009494 RSRC2 0.44 6.37 0.33 6.17e-10 Schizophrenia; LUSC cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg11657440 chr19:46296263 DMWD -0.64 -9.47 -0.46 5.2e-19 Coronary artery disease; LUSC cis rs11098499 0.754 rs10213554 chr4:120260785 A/G cg24375607 chr4:120327624 NA -0.72 -11.21 -0.52 5.61e-25 Corneal astigmatism; LUSC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg27170947 chr2:26402098 FAM59B -0.69 -9.97 -0.48 1.18e-20 Gut microbiome composition (summer); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg06740039 chr3:106959657 LOC344595;LOC100302640 -0.49 -6.38 -0.33 5.77e-10 Hepatitis; LUSC cis rs3770081 1.000 rs78032828 chr2:86309032 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -7.48 -0.38 6.53e-13 Facial emotion recognition (sad faces); LUSC cis rs17401966 1.000 rs7520935 chr1:10354271 G/T cg19773385 chr1:10388646 KIF1B -0.55 -8.46 -0.42 8.49e-16 Hepatocellular carcinoma; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg06600287 chr1:53387719 ECHDC2 -0.31 -6.53 -0.34 2.41e-10 Monocyte count; LUSC cis rs17125944 0.505 rs3783447 chr14:53191647 G/A cg00686598 chr14:53173677 PSMC6 1.06 9.66 0.47 1.27e-19 Alzheimer's disease (late onset); LUSC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg13319975 chr6:146136371 FBXO30 0.5 7.51 0.38 5.44e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2658782 1.000 rs2605582 chr11:93163799 C/T cg15737290 chr11:93063684 CCDC67 0.65 8.21 0.41 4.92e-15 Pulmonary function decline; LUSC trans rs629535 0.783 rs658407 chr8:70035247 T/C cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs17270561 0.609 rs2000351 chr6:25759783 T/C cg16482183 chr6:26056742 HIST1H1C 0.58 8.05 0.4 1.46e-14 Iron status biomarkers; LUSC cis rs12928939 0.769 rs1056303 chr16:71670066 C/T cg03805757 chr16:71968109 PKD1L3 -0.41 -5.96 -0.31 6.44e-9 Post bronchodilator FEV1; LUSC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg11812906 chr14:75593930 NEK9 0.64 10.47 0.5 2.34e-22 Height; LUSC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.45 6.45 0.33 3.85e-10 Breast cancer; LUSC cis rs9309473 0.607 rs10198301 chr2:73581600 T/A cg20560298 chr2:73613845 ALMS1 -0.57 -8.3 -0.41 2.62e-15 Metabolite levels; LUSC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg05623727 chr3:50126028 RBM5 0.31 5.7 0.3 2.61e-8 Intelligence (multi-trait analysis); LUSC cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs9291683 0.546 rs13146686 chr4:10034933 A/G cg26043149 chr18:55253948 FECH 0.47 6.95 0.36 1.93e-11 Bone mineral density; LUSC cis rs7589342 0.517 rs6726571 chr2:106390251 T/C cg14210321 chr2:106509881 NCK2 -0.4 -5.79 -0.3 1.63e-8 Addiction; LUSC cis rs921665 0.831 rs2368672 chr2:3188893 A/C cg16434511 chr2:3151078 NA -0.63 -6.78 -0.35 5.3e-11 World class endurance athleticism; LUSC cis rs804280 0.509 rs12719915 chr8:11786255 A/G cg00262122 chr8:11665843 FDFT1 -0.38 -5.66 -0.3 3.2e-8 Myopia (pathological); LUSC cis rs7432375 0.609 rs835637 chr3:136673157 A/T cg15507776 chr3:136538369 TMEM22 0.4 6.77 0.35 5.71e-11 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs11098499 0.604 rs17051352 chr4:120581427 G/A cg24375607 chr4:120327624 NA 0.73 10.38 0.49 4.58e-22 Corneal astigmatism; LUSC trans rs4714291 0.802 rs2983143 chr6:40044850 G/T cg02267698 chr19:7991119 CTXN1 -0.55 -7.99 -0.4 2.25e-14 Strep throat; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg21782813 chr7:2030301 MAD1L1 0.42 7.11 0.36 7.09e-12 Bipolar disorder and schizophrenia; LUSC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg08109568 chr15:31115862 NA 0.73 11.22 0.52 5.4e-25 Huntington's disease progression; LUSC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.6 0.57 4.65e-30 Hip circumference adjusted for BMI; LUSC cis rs2299587 0.642 rs2073570 chr8:17782627 C/G cg01800426 chr8:17659068 MTUS1 -0.42 -5.66 -0.3 3.21e-8 Economic and political preferences; LUSC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg11764359 chr7:65958608 NA 0.49 6.1 0.32 2.93e-9 Aortic root size; LUSC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg26408565 chr15:76604113 ETFA -0.52 -8.3 -0.41 2.6e-15 Blood metabolite levels; LUSC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg05855489 chr10:104503620 C10orf26 0.6 9.56 0.46 2.74e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs7582180 0.614 rs9973737 chr2:100942296 T/C cg12002119 chr2:101014098 CHST10 0.35 5.95 0.31 6.92e-9 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26149032 chr3:158519514 MFSD1 0.4 6.18 0.32 1.92e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2108225 0.900 rs2395930 chr7:107451677 T/C cg18560240 chr7:107437656 SLC26A3 -0.4 -6.2 -0.32 1.71e-9 Ulcerative colitis; LUSC cis rs714027 0.585 rs960987 chr22:30343477 C/T cg11564601 chr22:30592435 NA 0.35 6.01 0.31 4.75e-9 Lymphocyte counts; LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.45 -0.56 1.77e-29 Alzheimer's disease; LUSC cis rs4917833 0.510 rs754586 chr10:100224362 A/G cg19043522 chr10:100227446 HPSE2 0.45 6.56 0.34 1.99e-10 Pediatric bone mineral density (femoral neck); LUSC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg17279839 chr7:150038598 RARRES2 0.48 7.17 0.37 4.92e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs9549260 0.567 rs7332730 chr13:41265979 C/A cg21288729 chr13:41239152 FOXO1 0.56 8.36 0.42 1.67e-15 Red blood cell count; LUSC cis rs11748023 0.605 rs156090 chr5:139521684 T/C cg26211634 chr5:139558579 C5orf32 0.32 5.69 0.3 2.81e-8 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.78 0.35 5.5e-11 Platelet count; LUSC cis rs6545883 0.868 rs28749199 chr2:61827052 A/G cg15711740 chr2:61764176 XPO1 -0.47 -7.22 -0.37 3.49e-12 Tuberculosis; LUSC cis rs1335645 0.570 rs56273356 chr1:111664041 C/T cg00321911 chr1:111669324 DRAM2 -0.61 -6.77 -0.35 5.84e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9549260 0.522 rs4245401 chr13:41277736 G/T cg21288729 chr13:41239152 FOXO1 0.54 8.31 0.41 2.35e-15 Red blood cell count; LUSC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg23283495 chr1:209979779 IRF6 0.68 8.02 0.4 1.77e-14 Cleft lip with or without cleft palate; LUSC cis rs9325144 0.625 rs12227353 chr12:38734542 C/T cg26384229 chr12:38710491 ALG10B -0.6 -9.29 -0.45 2.04e-18 Morning vs. evening chronotype; LUSC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg17376030 chr22:41985996 PMM1 -0.47 -5.89 -0.31 9.6e-9 Vitiligo; LUSC cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.38 0.37 1.25e-12 Motion sickness; LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.24 0.32 1.33e-9 Menopause (age at onset); LUSC cis rs2439831 1.000 rs537115 chr15:43729948 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.97 10.95 0.51 4.92e-24 Lung cancer in ever smokers; LUSC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs9902453 0.904 rs12952179 chr17:28412687 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -10.95 -0.51 4.74e-24 Coffee consumption (cups per day); LUSC cis rs870825 1.000 rs870825 chr4:185588045 A/G cg04058563 chr4:185651563 MLF1IP 0.79 10.63 0.5 6.35e-23 Blood protein levels; LUSC cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg20283391 chr11:68216788 NA -0.59 -8.34 -0.42 2.01e-15 Total body bone mineral density; LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg27572855 chr1:25598939 RHD 0.47 8.49 0.42 7.09e-16 Erythrocyte sedimentation rate; LUSC cis rs7707921 0.881 rs17243791 chr5:81322547 A/G cg15871215 chr5:81402204 ATG10 -0.44 -6.41 -0.33 4.87e-10 Breast cancer; LUSC cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.26 0.49 1.16e-21 Bladder cancer; LUSC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg05084668 chr3:125655381 ALG1L -0.52 -7.89 -0.4 4.38e-14 Blood pressure (smoking interaction); LUSC cis rs77633900 0.772 rs2957607 chr15:76686527 A/G cg21673338 chr15:77095150 SCAPER 0.7 5.99 0.31 5.4e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs4925386 0.681 rs2427296 chr20:60927475 G/A cg22601191 chr20:60968625 CABLES2 0.43 6.11 0.32 2.73e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.76 0.35 6.34e-11 Lung cancer; LUSC cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs4891159 0.790 rs1787448 chr18:74113179 T/C cg24786174 chr18:74118243 ZNF516 0.83 15.26 0.64 2.93e-40 Longevity; LUSC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg19468946 chr17:37922297 IKZF3 -0.43 -6.89 -0.35 2.86e-11 Self-reported allergy; LUSC cis rs3125734 0.719 rs3852410 chr10:64037563 A/G cg09941381 chr10:64027924 RTKN2 0.35 6.3 0.33 9.47e-10 Rheumatoid arthritis; LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg24675658 chr1:53192096 ZYG11B -0.7 -11.57 -0.53 2.96e-26 Monocyte count; LUSC cis rs10207060 0.500 rs11884577 chr2:240702216 C/G cg20333904 chr2:240724165 NA -0.36 -6.26 -0.32 1.17e-9 Obesity-related traits; LUSC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.28 0.59 1.28e-32 Total body bone mineral density; LUSC cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg23583168 chr7:148888333 NA -0.84 -15.53 -0.65 2.51e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7193541 0.684 rs7201320 chr16:74694058 T/G cg01733217 chr16:74700730 RFWD3 0.97 21.87 0.77 1.96e-66 Multiple myeloma; LUSC cis rs7903847 0.642 rs10882923 chr10:99159018 G/A cg20016023 chr10:99160130 RRP12 -0.32 -7.86 -0.4 5.34e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs8017423 0.967 rs1959002 chr14:90670994 T/A cg04374321 chr14:90722782 PSMC1 0.7 10.94 0.51 5.08e-24 Mortality in heart failure; LUSC cis rs4730250 0.655 rs75243311 chr7:106890791 C/T cg02696742 chr7:106810147 HBP1 -0.63 -9.43 -0.46 7.2e-19 Osteoarthritis; LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.39 0.46 9.85e-19 Prudent dietary pattern; LUSC cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg23711669 chr6:146136114 FBXO30 0.74 13.07 0.58 7.88e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs68170813 0.562 rs7810216 chr7:107000353 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.51 -0.46 3.76e-19 Coronary artery disease; LUSC cis rs9644630 0.696 rs35736969 chr8:19319620 G/A cg01280390 chr8:19363452 CSGALNACT1 0.32 5.85 0.31 1.14e-8 Oropharynx cancer; LUSC cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg11764359 chr7:65958608 NA 0.81 13.62 0.6 6.38e-34 Aortic root size; LUSC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.25e-9 Life satisfaction; LUSC cis rs4746818 0.688 rs951718 chr10:70928044 A/G cg11621586 chr10:70884670 VPS26A 1.07 13.28 0.59 1.33e-32 Left atrial antero-posterior diameter; LUSC trans rs62103177 0.810 rs3902996 chr18:77630571 A/G cg14227996 chr4:17616232 MED28 0.79 7.68 0.39 1.76e-13 Opioid sensitivity; LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg27588902 chr6:42928151 GNMT -0.29 -6.46 -0.33 3.78e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7851660 0.874 rs13299924 chr9:100627562 C/T cg13688889 chr9:100608707 NA -0.56 -8.94 -0.44 2.73e-17 Strep throat; LUSC cis rs826838 0.585 rs4363678 chr12:38624514 G/A cg13010199 chr12:38710504 ALG10B 0.48 7.28 0.37 2.47e-12 Heart rate; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg21240523 chr9:130965902 CIZ1;DNM1 -0.49 -6.05 -0.31 3.98e-9 Height; LUSC trans rs1728785 1.000 rs12918865 chr16:68566546 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.47 0.38 6.96e-13 Ulcerative colitis; LUSC cis rs7267979 1.000 rs2027004 chr20:25350618 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.87 -0.7 1.34e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.4 6.15 0.32 2.15e-9 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg02018176 chr4:1364513 KIAA1530 0.52 8.97 0.44 2.25e-17 Obesity-related traits; LUSC cis rs968451 0.865 rs5757610 chr22:39707979 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.68 9.04 0.44 1.28e-17 Primary biliary cholangitis; LUSC cis rs9300255 0.508 rs1716176 chr12:123655467 T/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.33 -0.33 7.98e-10 Neutrophil percentage of white cells; LUSC cis rs9311676 0.656 rs11923253 chr3:58376992 G/A cg26110898 chr3:58419937 PDHB 0.42 6.68 0.34 9.75e-11 Systemic lupus erythematosus; LUSC cis rs868036 0.681 rs4776978 chr15:68108305 A/G cg08079166 chr15:68083412 MAP2K5 0.41 7.23 0.37 3.29e-12 Restless legs syndrome; LUSC cis rs478304 0.651 rs11227299 chr11:65549570 C/G cg17480646 chr11:65405466 SIPA1 -0.44 -5.7 -0.3 2.62e-8 Acne (severe); LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.62 0.62 8.89e-38 Platelet count; LUSC cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg11244672 chr19:19639970 YJEFN3 -0.56 -6.87 -0.35 3.14e-11 Bipolar disorder; LUSC cis rs2580764 0.565 rs7562292 chr2:55230219 C/T cg20993754 chr2:55226987 RTN4 0.35 5.84 0.3 1.25e-8 Mean platelet volume; LUSC cis rs66887589 0.616 rs13113885 chr4:120221176 G/C cg13609457 chr4:120235615 NA 0.4 6.16 0.32 2.12e-9 Diastolic blood pressure; LUSC cis rs3820928 0.874 rs56324594 chr2:227868854 C/T cg11843606 chr2:227700838 RHBDD1 -0.5 -7.15 -0.36 5.36e-12 Pulmonary function; LUSC cis rs4242434 0.536 rs1871900 chr8:22481449 A/G cg03733263 chr8:22462867 KIAA1967 0.66 10.53 0.5 1.43e-22 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs8017423 0.765 rs8017170 chr14:90721849 T/A cg04374321 chr14:90722782 PSMC1 0.75 12.12 0.55 2.92e-28 Mortality in heart failure; LUSC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg20135002 chr11:47629003 NA -0.51 -7.84 -0.39 5.97e-14 Subjective well-being; LUSC cis rs7954584 0.567 rs11043243 chr12:122356370 G/C cg21171335 chr12:122356390 WDR66 0.64 9.43 0.46 7.09e-19 Mean corpuscular volume; LUSC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg13206674 chr6:150067644 NUP43 0.59 9.47 0.46 5.18e-19 Lung cancer; LUSC cis rs929354 0.772 rs6957939 chr7:156978485 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs2692947 0.630 rs1168966 chr2:96798510 G/A cg23100626 chr2:96804247 ASTL 0.26 6.43 0.33 4.48e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.76 0.54 6.2e-27 Prudent dietary pattern; LUSC cis rs7712401 0.580 rs10076327 chr5:122367347 A/G cg19077854 chr5:122220652 SNX24 0.38 7.95 0.4 2.97e-14 Mean platelet volume; LUSC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg01416388 chr22:39784598 NA -0.45 -7.62 -0.38 2.69e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs12410462 0.581 rs73102371 chr1:227554880 G/A cg10327440 chr1:227177885 CDC42BPA -0.59 -5.79 -0.3 1.65e-8 Major depressive disorder; LUSC cis rs6964587 1.000 rs416 chr7:91580571 A/G cg22117172 chr7:91764530 CYP51A1 -0.32 -5.82 -0.3 1.41e-8 Breast cancer; LUSC cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg03264133 chr6:25882463 NA -0.51 -9.34 -0.46 1.37e-18 Blood metabolite levels; LUSC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg20608306 chr11:116969690 SIK3 0.37 5.7 0.3 2.67e-8 Blood protein levels; LUSC cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs1670533 1.000 rs6858612 chr4:1053353 C/T cg02018176 chr4:1364513 KIAA1530 0.43 6.18 0.32 1.89e-9 Recombination rate (females); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26985142 chr8:135724921 ZFAT -0.46 -6.94 -0.36 2.08e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg00071950 chr4:10020882 SLC2A9 0.55 9.23 0.45 3.15e-18 Bone mineral density; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03952484 chr1:149899818 SF3B4 0.42 6.3 0.33 9.55e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17270561 0.636 rs9393656 chr6:25722059 A/C cg17691542 chr6:26056736 HIST1H1C 0.56 7.89 0.4 4.46e-14 Iron status biomarkers; LUSC cis rs1577917 1.000 rs12205548 chr6:86759770 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.77 -0.35 5.91e-11 Response to antipsychotic treatment; LUSC cis rs11958404 0.932 rs72816592 chr5:157435246 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs9807989 0.811 rs11688573 chr2:102969971 C/A cg03938978 chr2:103052716 IL18RAP 0.31 5.79 0.3 1.58e-8 Asthma; LUSC cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg14438399 chr17:27053147 TLCD1 0.52 5.75 0.3 2.05e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.69 0.47 1.02e-19 Personality dimensions; LUSC cis rs10266483 0.739 rs682662 chr7:63766485 C/T cg24201672 chr7:64023550 ZNF680 -0.49 -6.56 -0.34 2.03e-10 Response to statin therapy; LUSC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11644478 chr21:40555479 PSMG1 0.63 10.23 0.49 1.49e-21 Cognitive function; LUSC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg07936489 chr17:37558343 FBXL20 0.71 9.69 0.47 1e-19 Glomerular filtration rate (creatinine); LUSC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.58 0.46 2.35e-19 Personality dimensions; LUSC cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.97 0.44 2.22e-17 Motion sickness; LUSC cis rs524023 1.000 rs10792441 chr11:64360629 C/T cg07220939 chr11:64358617 SLC22A12 -0.22 -5.76 -0.3 1.91e-8 Urate levels in obese individuals; LUSC cis rs4595586 0.525 rs4441057 chr12:39420620 T/A cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.38 4.39e-13 Morning vs. evening chronotype; LUSC cis rs1670533 1.000 rs6599279 chr4:1058833 G/A cg02018176 chr4:1364513 KIAA1530 0.44 5.99 0.31 5.57e-9 Recombination rate (females); LUSC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg26769984 chr7:1090371 C7orf50 0.54 7.4 0.38 1.15e-12 Bronchopulmonary dysplasia; LUSC cis rs782590 1.000 rs782590 chr2:55843413 C/T cg18811423 chr2:55921094 PNPT1 0.81 14.01 0.61 2.04e-35 Metabolic syndrome; LUSC cis rs17604090 0.877 rs57253003 chr7:29686556 T/C cg19413766 chr7:29689036 LOC646762 -0.58 -6.93 -0.35 2.12e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC trans rs225245 0.817 rs225273 chr17:33970935 A/T cg19694781 chr19:47549865 TMEM160 -0.41 -6.48 -0.33 3.21e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs1459104 0.866 rs28822225 chr11:54818606 C/G cg15704280 chr7:45808275 SEPT13 0.72 6.27 0.32 1.14e-9 Body mass index; LUSC cis rs8036030 0.604 rs11852686 chr15:74715205 A/G cg05926586 chr15:74592786 CCDC33 0.31 6.36 0.33 6.63e-10 Airflow obstruction; LUSC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg05347473 chr6:146136440 FBXO30 -0.67 -11.39 -0.53 1.34e-25 Lobe attachment (rater-scored or self-reported); LUSC trans rs66887589 0.967 rs2892869 chr4:120521297 T/C cg25214090 chr10:38739885 LOC399744 -0.38 -6.06 -0.31 3.66e-9 Diastolic blood pressure; LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC cis rs1595825 0.838 rs73056856 chr2:198801209 C/G cg10547527 chr2:198650123 BOLL -0.5 -5.86 -0.31 1.12e-8 Ulcerative colitis; LUSC cis rs7224314 1.000 rs8070284 chr17:65387400 A/G cg01507342 chr17:65387096 PITPNC1 -0.44 -7.79 -0.39 8.5e-14 Diisocyanate-induced asthma; LUSC cis rs7712401 0.601 rs397731 chr5:122322959 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs7191439 0.858 rs6500489 chr16:88772046 T/C cg27087555 chr16:88793112 FAM38A -1.37 -10.73 -0.51 2.82e-23 Plateletcrit; LUSC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.92 -0.31 7.93e-9 Neutrophil percentage of white cells; LUSC cis rs9733 0.650 rs12406712 chr1:150545084 C/A cg17724175 chr1:150552817 MCL1 -0.34 -5.84 -0.3 1.25e-8 Tonsillectomy; LUSC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg23743428 chr13:21893420 NA -0.42 -8.77 -0.43 9.44e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs208520 1.000 rs208537 chr6:66963544 A/G cg07460842 chr6:66804631 NA -0.96 -12.45 -0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg15649852 chr7:65879115 NA -0.41 -5.79 -0.3 1.6e-8 Aortic root size; LUSC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.65 13.64 0.6 5.57e-34 Monocyte percentage of white cells; LUSC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg08048268 chr3:133502702 NA -0.46 -8.87 -0.44 4.36e-17 Iron status biomarkers; LUSC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg06618935 chr21:46677482 NA -0.37 -7.26 -0.37 2.69e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs853679 0.607 rs34950484 chr6:28278688 G/A cg06606381 chr12:133084897 FBRSL1 -0.92 -8.75 -0.43 1.06e-16 Depression; LUSC cis rs9649213 0.511 rs6950994 chr7:97887872 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.51 -0.38 5.3e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.77e-9 Aortic root size; LUSC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg18477163 chr1:228402036 OBSCN -0.56 -10.21 -0.49 1.83e-21 Diastolic blood pressure; LUSC cis rs7772486 0.875 rs56181683 chr6:146286620 A/G cg23711669 chr6:146136114 FBXO30 -0.86 -15.24 -0.64 3.42e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg26408565 chr15:76604113 ETFA -0.49 -7.82 -0.39 6.87e-14 Blood metabolite levels; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg00024416 chr22:24240387 NA -0.33 -5.72 -0.3 2.32e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6088590 1.000 rs11696546 chr20:33452999 C/G cg08999081 chr20:33150536 PIGU 0.46 8.32 0.41 2.2e-15 Coronary artery disease; LUSC cis rs68170813 0.641 rs4730228 chr7:106904077 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs6062496 0.631 rs6062300 chr20:62303794 G/A cg27236539 chr20:62289627 RTEL1 0.7 10.9 0.51 7.21e-24 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.23 0.37 3.31e-12 Cognitive ability; LUSC cis rs4680 0.737 rs4818 chr22:19951207 C/G cg23601416 chr22:19950040 COMT -0.42 -8.63 -0.43 2.48e-16 Blood metabolite levels; LUSC cis rs9462027 0.628 rs58671447 chr6:34752351 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC cis rs644799 0.710 rs12273579 chr11:95524421 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.51 0.59 1.77e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs8018967 1.000 rs8018967 chr14:73976934 A/G cg08936952 chr14:74026160 HEATR4 0.42 7.31 0.37 2.01e-12 Blood metabolite ratios; LUSC cis rs10744422 0.843 rs3896870 chr12:123333611 T/C cg25930673 chr12:123319894 HIP1R -0.69 -6.93 -0.35 2.22e-11 Schizophrenia; LUSC cis rs1538970 0.961 rs4660854 chr1:45854087 A/T cg05343316 chr1:45956843 TESK2 0.63 9.1 0.45 8.39e-18 Platelet count; LUSC cis rs72781680 0.904 rs72796340 chr2:24143622 T/A cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC trans rs6502050 0.835 rs10163485 chr17:80110750 C/T cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.71e-10 Life satisfaction; LUSC trans rs225245 0.817 rs225269 chr17:33967931 G/T cg19694781 chr19:47549865 TMEM160 -0.42 -6.6 -0.34 1.66e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs926938 0.501 rs360686 chr1:115502524 C/T cg01522456 chr1:115632236 TSPAN2 -0.44 -6.77 -0.35 5.98e-11 Autism; LUSC cis rs1055129 0.560 rs9891076 chr17:73911715 C/T cg08125733 chr17:73851984 WBP2 0.5 7.01 0.36 1.31e-11 White matter hyperintensity burden; LUSC cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg08045932 chr20:61659980 NA 0.55 9.23 0.45 3.17e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6062509 1.000 rs6062509 chr20:62362563 G/T cg21849932 chr20:62369462 LIME1 -0.4 -5.84 -0.3 1.22e-8 Prostate cancer; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg27535305 chr1:53392650 SCP2 -0.4 -7.53 -0.38 4.72e-13 Monocyte count; LUSC cis rs7824557 0.606 rs2736270 chr8:11192593 G/A cg27411982 chr8:10470053 RP1L1 0.4 6.1 0.32 3.02e-9 Retinal vascular caliber; LUSC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg11494091 chr17:61959527 GH2 -0.64 -13.61 -0.6 7.4e-34 Prudent dietary pattern; LUSC cis rs13315871 1.000 rs9821570 chr3:58335919 C/G cg12435725 chr3:58293450 RPP14 -0.71 -7.65 -0.39 2.21e-13 Cholesterol, total; LUSC trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg11887960 chr12:57824829 NA 0.58 7.11 0.36 7.27e-12 Lung disease severity in cystic fibrosis; LUSC cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg24692254 chr21:30365293 RNF160 -0.82 -15.21 -0.64 4.55e-40 Dental caries; LUSC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.79 -0.35 5.05e-11 Lung cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07792560 chr11:66056572 YIF1A 0.73 6.18 0.32 1.91e-9 Cognitive performance; LUSC trans rs2797160 1.000 rs1739352 chr6:126005310 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.16e-10 Endometrial cancer; LUSC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg19912559 chr1:40204330 PPIE -0.52 -8.0 -0.4 2.01e-14 Blood protein levels; LUSC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg00825309 chr19:58991885 ZNF446 -0.5 -7.22 -0.37 3.64e-12 Uric acid clearance; LUSC cis rs11997175 0.603 rs7464053 chr8:33786938 C/A ch.8.33884649F chr8:33765107 NA 0.44 6.57 0.34 1.97e-10 Body mass index; LUSC cis rs662064 0.852 rs617728 chr1:10566522 C/T cg20482658 chr1:10539492 PEX14 0.32 6.44 0.33 4.11e-10 Asthma; LUSC cis rs6754311 0.731 rs309134 chr2:136755684 A/G cg07169764 chr2:136633963 MCM6 -0.7 -10.23 -0.49 1.52e-21 Mosquito bite size; LUSC trans rs11039798 0.920 rs11039848 chr11:48598243 C/T cg15704280 chr7:45808275 SEPT13 0.75 6.42 0.33 4.65e-10 Axial length; LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.62 -0.34 1.42e-10 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg16405210 chr4:1374714 KIAA1530 -0.53 -8.02 -0.4 1.78e-14 Obesity-related traits; LUSC cis rs1577917 0.958 rs1838958 chr6:86563968 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs7851660 0.809 rs7032086 chr9:100656402 T/G cg13688889 chr9:100608707 NA -0.55 -8.51 -0.42 6.16e-16 Strep throat; LUSC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg01416388 chr22:39784598 NA -0.46 -7.83 -0.39 6.56e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs79349575 0.783 rs62075818 chr17:46982327 T/A cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05901451 chr6:126070800 HEY2 0.87 16.25 0.66 3.79e-44 Brugada syndrome; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg21724239 chr8:58056113 NA 0.78 9.27 0.45 2.34e-18 Developmental language disorder (linguistic errors); LUSC cis rs34638657 0.673 rs11645286 chr16:82201898 C/A cg09439754 chr16:82129088 HSD17B2 -0.34 -5.72 -0.3 2.41e-8 Lung adenocarcinoma; LUSC cis rs977987 0.806 rs35683383 chr16:75479277 G/T cg03315344 chr16:75512273 CHST6 0.53 10.45 0.5 2.61e-22 Dupuytren's disease; LUSC cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg23711669 chr6:146136114 FBXO30 -0.83 -14.87 -0.63 9.93e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs8062405 0.691 rs743590 chr16:28608230 G/A cg07382826 chr16:28625726 SULT1A1 0.27 5.86 0.31 1.12e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg25282410 chr6:160211355 TCP1;MRPL18 1.13 17.23 0.69 4.9e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg21573476 chr21:45109991 RRP1B 0.41 6.56 0.34 2.03e-10 Mean corpuscular volume; LUSC cis rs7567389 0.510 rs1473623 chr2:128196220 T/C cg06038358 chr2:128176007 PROC -0.3 -5.98 -0.31 5.71e-9 Self-rated health; LUSC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg26335602 chr6:28129616 ZNF389 0.43 5.91 0.31 8.24e-9 Parkinson's disease; LUSC cis rs1670533 1.000 rs6599278 chr4:1058798 C/T cg02018176 chr4:1364513 KIAA1530 0.47 6.13 0.32 2.53e-9 Recombination rate (females); LUSC cis rs11190604 1.000 rs74650218 chr10:102293830 C/T cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs2295359 1.000 rs11465753 chr1:67631423 T/C cg03340356 chr1:67600835 NA 0.41 6.63 0.34 1.36e-10 Psoriasis; LUSC cis rs12681287 0.547 rs7461366 chr8:87511685 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs2710642 0.962 rs7567923 chr2:63085848 C/T cg17519650 chr2:63277830 OTX1 -0.49 -6.93 -0.35 2.14e-11 LDL cholesterol levels;LDL cholesterol; LUSC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg23590916 chr17:43697445 MGC57346 -0.49 -6.61 -0.34 1.52e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs727563 0.565 rs132774 chr22:42031953 C/G cg17376030 chr22:41985996 PMM1 0.5 6.31 0.33 9.09e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg23719950 chr11:63933701 MACROD1 -0.63 -8.07 -0.4 1.24e-14 Mean platelet volume; LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -8.97 -0.44 2.16e-17 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.51 0.69 3.59e-49 Chronic sinus infection; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg26304593 chr6:42947056 PEX6 -0.46 -7.0 -0.36 1.44e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs11098499 0.644 rs3806808 chr4:120551085 A/C cg25214090 chr10:38739885 LOC399744 0.42 6.54 0.34 2.27e-10 Corneal astigmatism; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.7 0.39 1.61e-13 Prudent dietary pattern; LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg27588902 chr6:42928151 GNMT 0.28 6.41 0.33 4.82e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg26384229 chr12:38710491 ALG10B 0.93 17.54 0.69 2.66e-49 Heart rate; LUSC cis rs2274273 0.870 rs10139000 chr14:55849876 G/T cg04306507 chr14:55594613 LGALS3 0.53 11.9 0.55 1.9e-27 Protein biomarker; LUSC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.46 -0.33 3.71e-10 Total body bone mineral density; LUSC cis rs701145 0.556 rs355763 chr3:154012881 C/T cg17054900 chr3:154042577 DHX36 0.44 5.73 0.3 2.3e-8 Coronary artery disease; LUSC cis rs17854409 0.881 rs1046784 chr20:61472808 G/C cg05147244 chr20:61493195 TCFL5 0.88 6.59 0.34 1.69e-10 Obesity-related traits; LUSC trans rs2392780 0.536 rs622556 chr8:128333197 C/T cg10195415 chr17:73887371 TRIM65 -0.4 -6.4 -0.33 5.21e-10 Breast cancer (early onset); LUSC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg07936489 chr17:37558343 FBXL20 0.71 9.91 0.48 1.88e-20 Glomerular filtration rate (creatinine); LUSC cis rs16854884 0.586 rs6440212 chr3:143748526 T/C cg06585982 chr3:143692056 C3orf58 0.52 8.29 0.41 2.86e-15 Economic and political preferences (feminism/equality); LUSC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.94 -0.31 6.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12101261 1.000 rs17111346 chr14:81452172 G/A cg06600135 chr14:81408086 NA 0.43 6.27 0.32 1.09e-9 Graves' disease; LUSC cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.74 8.67 0.43 1.88e-16 Schizophrenia; LUSC cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg24296786 chr1:45957014 TESK2 -0.49 -7.23 -0.37 3.35e-12 High light scatter reticulocyte count; LUSC cis rs2446066 0.799 rs11610326 chr12:53841854 G/T cg20730629 chr12:53886622 MAP3K12 -0.43 -5.79 -0.3 1.63e-8 Red blood cell count; LUSC cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg05855489 chr10:104503620 C10orf26 0.58 8.69 0.43 1.62e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs17685 0.712 rs6954569 chr7:75738885 T/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.04 -0.4 1.62e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -7.02 -0.36 1.24e-11 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs1165181 chr6:25825390 T/A cg16482183 chr6:26056742 HIST1H1C 0.56 8.01 0.4 1.89e-14 Iron status biomarkers; LUSC cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg12310025 chr6:25882481 NA -0.52 -9.54 -0.46 3.22e-19 Blood metabolite levels; LUSC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg06740227 chr12:86229804 RASSF9 0.42 6.55 0.34 2.21e-10 Major depressive disorder; LUSC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC trans rs11098499 0.645 rs78422072 chr4:120281042 C/T cg25214090 chr10:38739885 LOC399744 0.5 7.47 0.38 6.93e-13 Corneal astigmatism; LUSC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.44e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs9815354 0.857 rs12108064 chr3:42016217 C/T cg03022575 chr3:42003672 ULK4 0.56 5.92 0.31 7.96e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs4700695 0.719 rs36922 chr5:65464856 C/T cg21114390 chr5:65439923 SFRS12 -0.65 -9.28 -0.45 2.12e-18 Facial morphology (factor 19); LUSC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg26695010 chr11:65641043 EFEMP2 -0.51 -7.72 -0.39 1.35e-13 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs10751667 0.643 rs6597970 chr11:928669 C/A ch.11.42038R chr11:967971 AP2A2 0.41 6.16 0.32 2.14e-9 Alzheimer's disease (late onset); LUSC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg10356904 chr22:49881777 NA -0.34 -7.43 -0.38 8.98e-13 Monocyte count;Monocyte percentage of white cells; LUSC trans rs7824557 0.767 rs1897950 chr8:11169551 C/A cg08975724 chr8:8085496 FLJ10661 0.46 6.74 0.35 6.94e-11 Retinal vascular caliber; LUSC trans rs867371 0.519 rs1566559 chr15:82524461 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.38 -6.33 -0.33 7.96e-10 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs4132509 0.739 rs10927033 chr1:243695539 C/A cg21452805 chr1:244014465 NA 0.61 6.21 0.32 1.57e-9 RR interval (heart rate); LUSC cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg04586622 chr2:25135609 ADCY3 0.42 8.99 0.44 1.87e-17 Body mass index; LUSC trans rs7980799 0.649 rs7972688 chr12:33653477 T/C cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.31 4.25e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs8133932 0.690 rs432338 chr21:47347757 C/T cg14185626 chr21:47401492 COL6A1 -0.44 -5.65 -0.3 3.37e-8 Schizophrenia; LUSC cis rs7100689 0.784 rs3802637 chr10:82179699 G/C cg00277334 chr10:82204260 NA -0.55 -7.36 -0.37 1.44e-12 Post bronchodilator FEV1; LUSC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg17971929 chr21:40555470 PSMG1 -0.57 -9.08 -0.44 1e-17 Cognitive function; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20338300 chr2:56411534 CCDC85A 0.7 6.34 0.33 7.45e-10 Cognitive performance; LUSC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg04315214 chr1:2043799 PRKCZ -0.38 -7.54 -0.38 4.59e-13 Height; LUSC cis rs1595825 0.945 rs61184128 chr2:198843659 C/T cg10547527 chr2:198650123 BOLL -0.5 -5.85 -0.3 1.16e-8 Ulcerative colitis; LUSC cis rs400736 0.930 rs2745722 chr1:8056669 G/A cg25007680 chr1:8021821 PARK7 0.58 9.16 0.45 5.22e-18 Response to antidepressants and depression; LUSC cis rs6580649 0.941 rs1635529 chr12:48395102 T/G cg05342945 chr12:48394962 COL2A1 -0.46 -6.22 -0.32 1.52e-9 Lung cancer; LUSC cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg20701182 chr2:24300061 SF3B14 0.88 11.42 0.53 1.05e-25 Lymphocyte counts; LUSC cis rs427394 0.659 rs175594 chr5:6729885 T/G cg10857441 chr5:6722123 POLS -0.45 -8.31 -0.41 2.44e-15 Menopause (age at onset); LUSC cis rs372883 0.624 rs1153286 chr21:30684383 A/G cg08807101 chr21:30365312 RNF160 -0.66 -10.55 -0.5 1.2e-22 Pancreatic cancer; LUSC cis rs12762955 0.677 rs11250267 chr10:1156487 A/G cg26597838 chr10:835615 NA 0.45 5.84 0.3 1.23e-8 Response to angiotensin II receptor blocker therapy; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg17888837 chr1:27986674 NA 0.62 6.06 0.31 3.65e-9 Body mass index; LUSC cis rs11676348 0.791 rs4133195 chr2:218951245 A/G cg06547715 chr2:218990976 CXCR2 -0.32 -6.22 -0.32 1.5e-9 Ulcerative colitis; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg12034118 chr1:209979487 IRF6 0.74 14.11 0.61 8.8e-36 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC trans rs61931739 0.500 rs10844864 chr12:34532468 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.47 0.59 2.55e-33 Morning vs. evening chronotype; LUSC cis rs3008870 1.000 rs2815361 chr1:67494591 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.96 15.61 0.65 1.2e-41 Lymphocyte percentage of white cells; LUSC cis rs7927771 0.542 rs10769300 chr11:47865560 C/T cg20307385 chr11:47447363 PSMC3 0.46 6.77 0.35 5.93e-11 Subjective well-being; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg00166722 chr3:10149974 C3orf24 0.55 7.63 0.39 2.48e-13 Alzheimer's disease; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg17450446 chr1:160002111 PIGM 0.4 6.1 0.32 2.95e-9 Eotaxin levels; LUSC cis rs12545109 0.879 rs2576588 chr8:57381627 G/A cg09654669 chr8:57350985 NA -0.57 -7.87 -0.4 5.1e-14 Obesity-related traits; LUSC cis rs7512552 0.839 rs12040949 chr1:150447462 C/T cg15654264 chr1:150340011 RPRD2 0.65 10.78 0.51 1.9e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg26354017 chr1:205819088 PM20D1 0.52 8.56 0.42 4.21e-16 Menarche (age at onset); LUSC trans rs10432489 0.708 rs12693263 chr2:181740210 A/G cg11196870 chr8:41386826 GINS4 -0.88 -5.96 -0.31 6.38e-9 QT interval; LUSC trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg03929089 chr4:120376271 NA -0.82 -11.24 -0.52 4.28e-25 Coronary artery disease; LUSC cis rs240764 0.680 rs239234 chr6:101101234 G/A cg09795085 chr6:101329169 ASCC3 0.41 5.97 0.31 6.12e-9 Neuroticism; LUSC trans rs1728785 0.818 rs12926059 chr16:68569459 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.84 0.39 6.22e-14 Colorectal cancer; LUSC cis rs9640161 0.783 rs2021871 chr7:150071156 T/C cg17279839 chr7:150038598 RARRES2 0.35 5.76 0.3 1.92e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9467773 0.869 rs1796521 chr6:26421392 T/C cg05738196 chr6:26577821 NA -0.66 -10.51 -0.5 1.62e-22 Intelligence (multi-trait analysis); LUSC cis rs7903847 0.620 rs2297988 chr10:99118382 A/G cg08345082 chr10:99160200 RRP12 -0.35 -6.96 -0.36 1.82e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg13206674 chr6:150067644 NUP43 0.57 9.11 0.45 7.79e-18 Lung cancer; LUSC cis rs9487051 0.768 rs461487 chr6:109525504 A/G cg01475377 chr6:109611718 NA -0.35 -5.89 -0.31 9.21e-9 Reticulocyte fraction of red cells; LUSC cis rs12912251 1.000 rs12901215 chr15:38992893 G/A cg01338139 chr15:38987640 C15orf53 -0.51 -6.89 -0.35 2.74e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg19346786 chr7:2764209 NA -0.38 -6.58 -0.34 1.82e-10 Height; LUSC cis rs7103648 0.553 rs12803857 chr11:47890172 G/A cg20307385 chr11:47447363 PSMC3 0.78 11.15 0.52 9.7e-25 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.01e-10 Blood pressure (smoking interaction); LUSC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg06742321 chr12:123595122 PITPNM2 0.37 5.68 0.3 2.88e-8 Platelet count; LUSC cis rs782590 0.837 rs782584 chr2:55921116 C/G cg03859395 chr2:55845619 SMEK2 -0.84 -15.01 -0.63 2.9e-39 Metabolic syndrome; LUSC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg13798780 chr7:105162888 PUS7 0.55 5.72 0.3 2.34e-8 Bipolar disorder (body mass index interaction); LUSC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.32 -0.49 7.39e-22 Bipolar disorder; LUSC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg01657329 chr11:68192670 LRP5 -0.46 -7.31 -0.37 2e-12 Total body bone mineral density; LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg20887711 chr4:1340912 KIAA1530 0.54 8.27 0.41 3.22e-15 Obesity-related traits; LUSC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs727505 1.000 rs34986416 chr7:124441017 A/G cg23710748 chr7:124431027 NA -0.44 -7.84 -0.39 5.92e-14 Lewy body disease; LUSC cis rs2486288 0.656 rs11629858 chr15:45547114 T/C cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.4e-10 Glomerular filtration rate; LUSC cis rs131777 0.575 rs131760 chr22:51011936 T/C cg25575065 chr22:51066394 ARSA -0.42 -5.81 -0.3 1.46e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9039 0.550 rs12924785 chr16:9219285 T/G cg08831531 chr16:9218945 NA -0.55 -8.93 -0.44 2.9e-17 Menopause (age at onset); LUSC trans rs7568069 0.864 rs7609266 chr2:71530558 G/C cg06465196 chr4:154387603 KIAA0922 0.42 6.04 0.31 4.18e-9 Height; LUSC trans rs208515 0.556 rs12201658 chr6:66678457 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.01 13.77 0.6 1.75e-34 Exhaled nitric oxide levels; LUSC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg00784671 chr22:46762841 CELSR1 -0.48 -5.97 -0.31 6.04e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg07167872 chr1:205819463 PM20D1 0.89 17.21 0.69 5.49e-48 Menarche (age at onset); LUSC cis rs7241530 0.636 rs8096302 chr18:75909790 T/A cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC cis rs9311676 0.656 rs12496906 chr3:58390490 A/C cg26110898 chr3:58419937 PDHB 0.4 6.42 0.33 4.56e-10 Systemic lupus erythematosus; LUSC trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg03929089 chr4:120376271 NA -0.85 -11.71 -0.54 9.13e-27 Coronary artery disease; LUSC trans rs9860340 0.730 rs1509781 chr3:87641568 A/T cg03644585 chr7:884825 UNC84A 0.42 6.03 0.31 4.35e-9 Electroencephalographic traits in alcoholism; LUSC cis rs2262909 0.962 rs436662 chr19:22232107 C/T cg11619707 chr19:22235551 ZNF257 -0.38 -5.7 -0.3 2.7e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg00310523 chr12:86230176 RASSF9 -0.43 -8.03 -0.4 1.67e-14 Major depressive disorder; LUSC cis rs62400317 0.859 rs12193030 chr6:45175210 G/A cg20913747 chr6:44695427 NA -0.48 -7.69 -0.39 1.64e-13 Total body bone mineral density; LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg19318889 chr4:1322082 MAEA 0.47 7.68 0.39 1.78e-13 Obesity-related traits; LUSC cis rs9653442 0.545 rs1821826 chr2:100764711 C/T cg07810366 chr2:100720526 AFF3 -0.45 -7.68 -0.39 1.83e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7819412 0.521 rs10100660 chr8:11038885 T/A cg21775007 chr8:11205619 TDH -0.48 -6.54 -0.34 2.3e-10 Triglycerides; LUSC cis rs6424115 0.830 rs1130320 chr1:24200606 A/G cg15997130 chr1:24165203 NA 0.52 8.58 0.43 3.6e-16 Immature fraction of reticulocytes; LUSC cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg03146154 chr1:46216737 IPP -0.57 -8.19 -0.41 5.73e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg13206674 chr6:150067644 NUP43 0.61 9.82 0.47 3.55e-20 Lung cancer; LUSC cis rs3806843 0.966 rs3806842 chr5:140212676 C/T cg03975922 chr5:140080575 ZMAT2 0.34 6.26 0.32 1.21e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -7.5 -0.38 6e-13 Axial length; LUSC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg18225595 chr11:63971243 STIP1 0.5 6.28 0.32 1.06e-9 Mean platelet volume; LUSC cis rs10193935 0.901 rs10171643 chr2:42532912 C/T cg27598129 chr2:42591480 NA -0.58 -8.14 -0.41 7.94e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs13040088 1.000 rs6090159 chr20:61531351 C/G cg23096297 chr20:61557774 DIDO1 0.83 11.39 0.53 1.26e-25 Menopause (age at onset); LUSC cis rs9303401 0.614 rs34843288 chr17:57103140 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.16 0.55 2.13e-28 Cognitive test performance; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg07677032 chr17:61819896 STRADA 0.55 9.25 0.45 2.78e-18 Prudent dietary pattern; LUSC trans rs11098499 0.954 rs13113483 chr4:120309039 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg14552801 chr7:65878734 NA -0.43 -6.09 -0.32 3.05e-9 Aortic root size; LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg11062466 chr8:58055876 NA 0.58 8.18 0.41 6.01e-15 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg09034736 chr1:150693464 HORMAD1 0.46 6.74 0.35 6.87e-11 Tonsillectomy; LUSC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.89 12.33 0.56 5.01e-29 Smoking behavior; LUSC cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.31 -0.37 1.96e-12 Menopause (age at onset); LUSC cis rs6494488 0.500 rs1133357 chr15:64987570 G/A cg08069370 chr15:64387884 SNX1 -0.68 -5.9 -0.31 8.97e-9 Coronary artery disease; LUSC cis rs11997175 0.524 rs10954932 chr8:33650176 A/C ch.8.33884649F chr8:33765107 NA 0.51 8.34 0.42 1.94e-15 Body mass index; LUSC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg10018233 chr7:150070692 REPIN1 -0.39 -7.0 -0.36 1.37e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs865483 0.929 rs853194 chr17:35848045 A/C cg06716730 chr17:35851459 DUSP14 0.28 6.21 0.32 1.54e-9 Monocyte count; LUSC cis rs9650315 0.866 rs7822536 chr8:57168085 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.87 0.35 3.07e-11 Height; LUSC cis rs6977660 0.714 rs12530537 chr7:19822641 A/G cg07541023 chr7:19748670 TWISTNB -0.56 -6.12 -0.32 2.61e-9 Thyroid stimulating hormone; LUSC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg07936489 chr17:37558343 FBXL20 -0.72 -9.95 -0.48 1.38e-20 Glomerular filtration rate (creatinine); LUSC cis rs10744422 0.858 rs12426809 chr12:123327143 C/T cg25930673 chr12:123319894 HIP1R -0.63 -6.23 -0.32 1.41e-9 Schizophrenia; LUSC cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg11244672 chr19:19639970 YJEFN3 -0.58 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs11105298 0.891 rs11105287 chr12:89829470 C/T cg00757033 chr12:89920650 WDR51B 0.54 9.46 0.46 5.91e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19372772 chr2:264904 ACP1;SH3YL1 -0.45 -6.41 -0.33 4.86e-10 Electrocardiographic conduction measures; LUSC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg22535103 chr8:58192502 C8orf71 -0.79 -8.06 -0.4 1.36e-14 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 14.04 0.61 1.6e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg21918786 chr6:109611834 NA -0.42 -7.34 -0.37 1.6e-12 Reticulocyte fraction of red cells; LUSC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs2708377 0.858 rs73051630 chr12:11147188 G/A cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.83 8.18 0.41 5.97e-15 Bitter taste perception; LUSC cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.04 0.4 1.54e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg17644776 chr2:200775616 C2orf69 0.4 6.27 0.32 1.12e-9 Schizophrenia; LUSC trans rs17685 0.633 rs3801471 chr7:75696188 T/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.9 0.74 1.14e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs735396 1.000 rs1169311 chr12:121440731 C/T cg02403541 chr12:121454288 C12orf43 0.59 8.45 0.42 8.98e-16 N-glycan levels; LUSC cis rs11105298 0.891 rs4842664 chr12:89938030 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.21 -0.37 3.65e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs950169 0.881 rs34591918 chr15:84950833 C/T cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg24250549 chr1:154909240 PMVK -0.42 -6.34 -0.33 7.36e-10 Prostate cancer; LUSC cis rs2404602 0.503 rs284909 chr15:76736628 C/T cg23625390 chr15:77176239 SCAPER 0.53 8.31 0.41 2.43e-15 Blood metabolite levels; LUSC cis rs7769051 0.522 rs73554461 chr6:133139087 T/G cg22852734 chr6:133119734 C6orf192 1.25 10.76 0.51 2.15e-23 Type 2 diabetes nephropathy; LUSC cis rs3845702 0.736 rs72962517 chr2:180861452 G/A cg01881094 chr2:180872142 CWC22 1.03 12.16 0.55 2.04e-28 Schizophrenia; LUSC cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.43e-32 Chronic sinus infection; LUSC cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg25019033 chr10:957182 NA -0.58 -7.64 -0.39 2.3e-13 Eosinophil percentage of granulocytes; LUSC cis rs55665837 1.000 rs10832256 chr11:14442875 G/A cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs9650315 0.866 rs72656034 chr8:57194766 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.13 0.36 6.25e-12 Height; LUSC trans rs61931739 0.927 rs12315970 chr12:34038535 A/G cg26384229 chr12:38710491 ALG10B -0.51 -7.78 -0.39 8.95e-14 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg27170947 chr2:26402098 FAM59B -0.66 -9.56 -0.46 2.57e-19 Gut microbiome composition (summer); LUSC cis rs9399401 0.634 rs984932 chr6:142803037 C/T cg03128060 chr6:142623767 GPR126 0.41 6.82 0.35 4.39e-11 Chronic obstructive pulmonary disease; LUSC cis rs11866815 0.817 rs9935993 chr16:401209 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 -0.4 -6.34 -0.33 7.24e-10 Body mass index; LUSC cis rs7188861 0.768 rs423674 chr16:11373405 G/T cg00044050 chr16:11439710 C16orf75 0.54 6.1 0.32 2.87e-9 HDL cholesterol; LUSC cis rs34779708 0.931 rs34954932 chr10:35410807 G/T cg03585969 chr10:35415529 CREM 0.58 8.67 0.43 1.87e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg04414720 chr1:150670196 GOLPH3L -0.48 -7.57 -0.38 3.74e-13 Tonsillectomy; LUSC cis rs8028313 0.731 rs4331293 chr15:67987801 A/G cg08079166 chr15:68083412 MAP2K5 0.35 5.97 0.31 5.96e-9 Obesity; LUSC cis rs7605827 0.930 rs11692624 chr2:15499127 C/T cg19274914 chr2:15703543 NA 0.46 8.88 0.44 4.15e-17 Educational attainment (years of education); LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg08859206 chr1:53392774 SCP2 -0.68 -12.93 -0.58 2.87e-31 Monocyte count; LUSC trans rs4800353 0.929 rs9952389 chr18:19608773 T/G cg01841828 chr16:69166849 CHTF8;CIRH1A -0.58 -6.05 -0.31 3.85e-9 Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6469656 1.000 rs6469656 chr8:117647788 G/A cg24004040 chr8:117650383 NA -0.43 -6.19 -0.32 1.81e-9 Colorectal cancer; LUSC cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg12011299 chr4:100065546 ADH4 -0.72 -10.45 -0.5 2.7e-22 Smoking initiation; LUSC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.72 -6.82 -0.35 4.31e-11 Cerebrospinal P-tau181p levels; LUSC cis rs12474201 0.928 rs17822019 chr2:46934505 T/C cg06386533 chr2:46925753 SOCS5 0.78 11.76 0.54 6.14e-27 Height; LUSC cis rs68170813 0.559 rs12540475 chr7:106886295 C/T cg02696742 chr7:106810147 HBP1 -0.63 -9.51 -0.46 3.83e-19 Coronary artery disease; LUSC cis rs4363385 0.530 rs10888529 chr1:153050654 G/T cg00922841 chr1:152955080 SPRR1A -0.39 -6.64 -0.34 1.27e-10 Inflammatory skin disease; LUSC cis rs3796619 1.000 rs4974638 chr4:1099201 G/A cg27284194 chr4:1044797 NA 0.49 7.68 0.39 1.8e-13 Recombination rate (males); LUSC cis rs17739794 0.517 rs6559193 chr8:775451 C/T cg01971667 chr8:817044 NA -0.41 -6.53 -0.34 2.51e-10 Clozapine-induced cytotoxicity; LUSC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg02951883 chr7:2050386 MAD1L1 -0.4 -6.95 -0.36 1.91e-11 Schizophrenia; LUSC trans rs7819412 0.669 rs6601568 chr8:11073402 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -7.8 -0.39 8.23e-14 Triglycerides; LUSC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg26566898 chr11:117069891 TAGLN 0.48 8.57 0.42 3.81e-16 Blood protein levels; LUSC cis rs9921192 0.967 rs3747571 chr16:4323983 A/G cg07945448 chr16:4304224 NA 0.46 6.58 0.34 1.77e-10 Prostate-specific antigen levels; LUSC cis rs9403521 1.000 rs7776119 chr6:144003643 A/G cg18240653 chr6:144019428 PHACTR2 -0.48 -5.93 -0.31 7.7e-9 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04794120 chr7:48019205 HUS1 -0.37 -6.11 -0.32 2.84e-9 Electrocardiographic conduction measures; LUSC cis rs7598759 0.527 rs12987949 chr2:232367511 A/G cg19187155 chr2:232395269 NMUR1 0.93 16.05 0.66 2.33e-43 Noise-induced hearing loss; LUSC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7809950 0.817 rs2712195 chr7:107127496 C/T cg23024343 chr7:107201750 COG5 -0.68 -10.18 -0.49 2.17e-21 Coronary artery disease; LUSC cis rs4343996 1.000 rs6966619 chr7:3359491 A/T cg21248987 chr7:3385318 SDK1 0.39 6.5 0.33 2.98e-10 Motion sickness; LUSC cis rs9300255 0.602 rs2851438 chr12:123643689 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.14 -0.32 2.38e-9 Neutrophil percentage of white cells; LUSC cis rs524023 0.914 rs7932437 chr11:64373504 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.5 -0.5 1.8e-22 Urate levels in obese individuals; LUSC cis rs2346177 0.605 rs7598712 chr2:46660452 G/T cg02822958 chr2:46747628 ATP6V1E2 0.42 7.21 0.37 3.7e-12 HDL cholesterol; LUSC cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg26384229 chr12:38710491 ALG10B -0.63 -9.82 -0.47 3.7799999999999997e-20 Morning vs. evening chronotype; LUSC cis rs7399018 1.000 rs7399018 chr12:51610365 C/T cg12163867 chr12:51592794 POU6F1 0.37 6.09 0.32 3.17e-9 Cisplatin-induced ototoxicity; LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg15790184 chr11:494944 RNH1 0.59 6.36 0.33 6.8e-10 Body mass index; LUSC cis rs765787 0.530 rs2433227 chr15:45517119 A/T cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.44e-17 Uric acid levels; LUSC cis rs2348418 0.715 rs12307709 chr12:28719700 G/A cg13890972 chr12:28721907 NA -0.39 -6.87 -0.35 3.24e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs2425143 1.000 rs11696947 chr20:34312658 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.27 -0.32 1.14e-9 Blood protein levels; LUSC cis rs3858526 0.834 rs7125255 chr11:5980384 T/A cg25319279 chr11:5960081 NA -0.44 -6.2 -0.32 1.63e-9 DNA methylation (variation); LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg05025164 chr4:1340916 KIAA1530 -0.5 -7.63 -0.39 2.48e-13 Obesity-related traits; LUSC cis rs2070488 0.804 rs13092473 chr3:38458958 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 12.25 0.56 9.92e-29 Electrocardiographic conduction measures; LUSC cis rs11264799 0.603 rs12118837 chr1:157561302 G/A cg18268488 chr1:157545234 FCRL4 0.35 6.23 0.32 1.39e-9 IgA nephropathy; LUSC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg11211951 chr8:145729740 GPT -0.54 -10.75 -0.51 2.5e-23 Age at first birth; LUSC trans rs7647973 0.593 rs58339610 chr3:49845006 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.63 7.41 0.38 1.05e-12 Menarche (age at onset); LUSC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg04450456 chr4:17643702 FAM184B 0.39 6.73 0.35 7.39e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs614226 1.000 rs591992 chr12:121019323 T/C cg21053147 chr12:120880522 NA -0.48 -5.83 -0.3 1.33e-8 Type 1 diabetes nephropathy; LUSC cis rs7605827 0.930 rs11902167 chr2:15494391 C/T cg19274914 chr2:15703543 NA 0.44 8.31 0.41 2.47e-15 Educational attainment (years of education); LUSC cis rs10489202 1.000 rs4656564 chr1:167928992 T/C cg24449463 chr1:168025552 DCAF6 -0.57 -7.28 -0.37 2.47e-12 Schizophrenia; LUSC cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg27279351 chr12:120934652 DYNLL1 0.64 8.49 0.42 7.04e-16 High light scatter reticulocyte count; LUSC cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg03146154 chr1:46216737 IPP 0.51 7.68 0.39 1.8e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.94 0.55 1.27e-27 Personality dimensions; LUSC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg18230493 chr5:56204884 C5orf35 -0.87 -13.23 -0.59 2.01e-32 Initial pursuit acceleration; LUSC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs9790314 0.967 rs10804790 chr3:161039300 T/A cg04691961 chr3:161091175 C3orf57 -0.36 -6.12 -0.32 2.6e-9 Morning vs. evening chronotype; LUSC cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg06108461 chr20:60628389 TAF4 -0.93 -15.59 -0.65 1.53e-41 Body mass index; LUSC cis rs611744 0.669 rs13251024 chr8:109258333 T/C cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 7.89e-10 Dupuytren's disease; LUSC cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg23711669 chr6:146136114 FBXO30 0.81 14.15 0.61 5.9e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg09877947 chr5:131593287 PDLIM4 0.42 6.86 0.35 3.42e-11 Blood metabolite levels; LUSC cis rs11048434 0.723 rs1805737 chr12:9084670 A/T cg13575925 chr12:9217583 LOC144571 0.35 6.29 0.33 9.93e-10 Sjögren's syndrome; LUSC cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg05347473 chr6:146136440 FBXO30 -0.48 -8.04 -0.4 1.55e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg11645453 chr3:52864694 ITIH4 0.56 13.65 0.6 5.3e-34 Schizophrenia; LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg05368731 chr17:41323189 NBR1 0.93 16.05 0.66 2.27e-43 Menopause (age at onset); LUSC cis rs8051149 0.576 rs731710 chr16:87884547 A/G cg01412419 chr16:87856264 NA 0.4 6.59 0.34 1.76e-10 Blood metabolite levels; LUSC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg05872129 chr22:39784769 NA -0.54 -8.03 -0.4 1.64e-14 IgG glycosylation; LUSC cis rs6500602 0.627 rs3848372 chr16:4587875 C/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 7.53 0.38 4.9e-13 Schizophrenia; LUSC cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg02527881 chr3:46936655 PTH1R 0.62 11.17 0.52 7.65e-25 Birth weight; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17747171 chr20:2633605 NOP56;SNORD110 -0.47 -6.39 -0.33 5.62e-10 Hepatitis; LUSC cis rs6121246 0.567 rs6120890 chr20:30207659 T/G cg13852791 chr20:30311386 BCL2L1 0.73 8.39 0.42 1.35e-15 Mean corpuscular hemoglobin; LUSC cis rs6977660 1.000 rs714238 chr7:19803925 C/T cg07541023 chr7:19748670 TWISTNB 0.53 6.07 0.32 3.48e-9 Thyroid stimulating hormone; LUSC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg18252515 chr7:66147081 NA -1.23 -13.41 -0.59 4.23e-33 Diabetic kidney disease; LUSC cis rs11098499 0.863 rs7669520 chr4:120515278 T/C cg24375607 chr4:120327624 NA 0.76 11.41 0.53 1.09e-25 Corneal astigmatism; LUSC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.59 7.86 0.4 5.19e-14 Lung function (FEV1/FVC); LUSC trans rs57046232 0.552 rs1305008 chr20:6324198 T/G cg21095983 chr6:86352623 SYNCRIP 0.49 7.27 0.37 2.59e-12 Colorectal cancer; LUSC cis rs354225 0.584 rs11898033 chr2:54821518 G/A cg01766943 chr2:54829624 SPTBN1 0.49 8.01 0.4 1.91e-14 Schizophrenia; LUSC cis rs72949976 0.646 rs4673731 chr2:214028544 C/T cg08319019 chr2:214017104 IKZF2 0.68 11.28 0.53 3.09e-25 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs2070433 0.800 rs2073380 chr21:47863757 A/C cg12379764 chr21:47803548 PCNT 0.77 9.71 0.47 8.83e-20 Lymphocyte counts; LUSC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg21918786 chr6:109611834 NA -0.41 -7.2 -0.37 3.92e-12 Reticulocyte fraction of red cells; LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg07507251 chr3:52567010 NT5DC2 0.32 6.25 0.32 1.25e-9 Bipolar disorder; LUSC cis rs317689 0.819 rs317667 chr12:69703754 G/T cg20891283 chr12:69753455 YEATS4 0.45 6.18 0.32 1.82e-9 Response to diuretic therapy; LUSC trans rs2018683 1.000 rs740252 chr7:28997765 C/G cg19402173 chr7:128379420 CALU -0.58 -9.4 -0.46 9.23e-19 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs3820928 1.000 rs61067328 chr2:227761256 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.72e-14 Pulmonary function; LUSC cis rs17490626 0.568 rs12413523 chr10:71211664 C/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.43 -0.46 7e-19 Thrombosis; LUSC cis rs10791097 0.694 rs2155749 chr11:130751094 G/T cg12179176 chr11:130786555 SNX19 0.86 15.12 0.64 1.06e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs10193935 0.901 rs222463 chr2:42644080 A/G cg27598129 chr2:42591480 NA -0.59 -8.0 -0.4 2.03e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs2492906 0.600 rs1907396 chr10:28064886 A/G cg18538961 chr14:101363192 MEG8 0.4 6.19 0.32 1.81e-9 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg21862992 chr11:68658383 NA 0.5 7.7 0.39 1.55e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs35883536 0.609 rs12747197 chr1:101036831 A/C cg09408571 chr1:101003634 GPR88 -0.3 -5.82 -0.3 1.35e-8 Monocyte count; LUSC cis rs9359856 0.956 rs6934804 chr6:90316020 A/G cg13799429 chr6:90582589 CASP8AP2 0.51 6.0 0.31 5.1e-9 Bipolar disorder; LUSC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg17279839 chr7:150038598 RARRES2 0.54 7.96 0.4 2.72e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs9894429 0.527 rs7405469 chr17:79566596 G/C cg18240062 chr17:79603768 NPLOC4 -0.55 -8.34 -0.42 2.01e-15 Eye color traits; LUSC cis rs9650657 0.655 rs4841434 chr8:10586123 T/C cg27411982 chr8:10470053 RP1L1 -0.41 -6.32 -0.33 8.31e-10 Neuroticism; LUSC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9399135 0.967 rs6929661 chr6:135328792 G/A cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Red blood cell count; LUSC trans rs7465272 1.000 rs13258638 chr8:143683582 C/T cg23094728 chr5:56110263 MAP3K1 0.45 5.99 0.31 5.53e-9 Bipolar disorder and schizophrenia; LUSC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.51 -0.38 5.33e-13 Electroencephalogram traits; LUSC cis rs7909074 0.766 rs5000415 chr10:45383674 C/T cg04218760 chr10:45406644 TMEM72 -0.28 -6.85 -0.35 3.52e-11 Mean corpuscular volume; LUSC cis rs1008375 1.000 rs7671752 chr4:17661398 C/T cg18681998 chr4:17616180 MED28 0.85 15.44 0.65 5.73e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12701220 0.504 rs12702092 chr7:1145868 G/A cg00990874 chr7:1149470 C7orf50 -0.59 -6.82 -0.35 4.4e-11 Bronchopulmonary dysplasia; LUSC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.02 0.44 1.52e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs7617773 0.746 rs4130995 chr3:48358255 C/T cg20734569 chr3:48348370 SPINK8 -0.42 -7.3 -0.37 2.09e-12 Coronary artery disease; LUSC cis rs8141529 0.732 rs6005881 chr22:29183133 A/G cg15103426 chr22:29168792 CCDC117 0.58 7.95 0.4 2.91e-14 Lymphocyte counts; LUSC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg17279839 chr7:150038598 RARRES2 0.56 8.37 0.42 1.66e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.6 0.78 2.79e-69 Prudent dietary pattern; LUSC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg01973587 chr1:228161476 NA 0.47 8.51 0.42 6.11e-16 Diastolic blood pressure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07316298 chr16:32823289 NA 0.48 6.5 0.34 2.95e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.56 8.73 0.43 1.23e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1538970 0.884 rs781232 chr1:45890399 C/T cg05343316 chr1:45956843 TESK2 -0.6 -8.22 -0.41 4.7e-15 Platelet count; LUSC cis rs11676348 0.805 rs12694428 chr2:218958820 G/A cg06547715 chr2:218990976 CXCR2 0.31 5.84 0.3 1.22e-8 Ulcerative colitis; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg05552183 chr6:42928497 GNMT 0.54 9.16 0.45 5.24e-18 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2692947 0.760 rs2438924 chr2:96645069 A/G cg23100626 chr2:96804247 ASTL 0.23 5.76 0.3 1.93e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg02415014 chr8:143852576 LYNX1 -0.27 -6.06 -0.31 3.67e-9 Urinary tract infection frequency; LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg22907277 chr7:1156413 C7orf50 0.71 7.56 0.38 3.84e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs509208 0.818 rs679040 chr3:166031056 C/G cg11340785 chr5:61374735 NA 0.38 5.96 0.31 6.55e-9 Alzheimer's disease biomarkers; LUSC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg18225595 chr11:63971243 STIP1 0.49 6.08 0.32 3.24e-9 Mean platelet volume; LUSC cis rs6541297 1.000 rs6665260 chr1:230279067 G/T cg05784532 chr1:230284198 GALNT2 0.49 7.39 0.38 1.16e-12 Coronary artery disease; LUSC cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg12011299 chr4:100065546 ADH4 0.72 10.6 0.5 8.19e-23 Smoking initiation; LUSC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg02782426 chr3:40428986 ENTPD3 0.38 6.97 0.36 1.7e-11 Renal cell carcinoma; LUSC cis rs28829049 0.535 rs12565185 chr1:19498309 G/A cg13387374 chr1:19411106 UBR4 0.44 6.13 0.32 2.44e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs1595825 0.679 rs11685247 chr2:198466462 C/A cg00982548 chr2:198649783 BOLL -0.52 -6.52 -0.34 2.53e-10 Ulcerative colitis; LUSC cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg12310025 chr6:25882481 NA -0.52 -9.63 -0.47 1.59e-19 Blood metabolite levels; LUSC cis rs1775715 0.870 rs1251400 chr10:32235145 A/G cg04359828 chr10:32216031 ARHGAP12 0.4 6.88 0.35 3.05e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12188164 0.525 rs1114665 chr5:452247 C/T cg00049323 chr5:472564 LOC25845 0.5 7.77 0.39 9.86e-14 Cystic fibrosis severity; LUSC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7223966 1.000 rs7209435 chr17:61712964 T/C cg05941027 chr17:61774174 LIMD2 0.23 6.4 0.33 5.39e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg27170947 chr2:26402098 FAM59B 0.68 10.27 0.49 1.11e-21 Gut microbiome composition (summer); LUSC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg11663144 chr21:46675770 NA -0.4 -6.98 -0.36 1.57e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg24562669 chr7:97807699 LMTK2 0.35 6.23 0.32 1.4e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs11098499 0.618 rs35265692 chr4:120325135 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.28 0.32 1.07e-9 Corneal astigmatism; LUSC cis rs6582630 0.502 rs4379906 chr12:38295673 G/A cg13010199 chr12:38710504 ALG10B 0.65 10.07 0.48 5.33e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs478304 0.651 rs78412025 chr11:65495696 T/C cg27068330 chr11:65405492 SIPA1 -0.76 -10.88 -0.51 8.57e-24 Acne (severe); LUSC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 9.82 0.47 3.76e-20 Menopause (age at onset); LUSC cis rs3770081 0.793 rs58186343 chr2:86218400 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.06 -6.77 -0.35 5.96e-11 Facial emotion recognition (sad faces); LUSC cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg00012203 chr2:219082015 ARPC2 -0.71 -11.87 -0.54 2.36e-27 Colorectal cancer; LUSC cis rs9341808 0.621 rs2322627 chr6:80806341 T/A cg08355045 chr6:80787529 NA 0.61 11.51 0.53 4.97e-26 Sitting height ratio; LUSC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg19717773 chr7:2847554 GNA12 -0.34 -6.0 -0.31 5.09e-9 Height; LUSC cis rs4604732 0.578 rs12038656 chr1:247623816 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.36 0.33 6.6e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg15468180 chr1:107600409 PRMT6 0.36 5.67 0.3 3.1e-8 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs11105298 0.786 rs10777186 chr12:89921277 G/A cg00757033 chr12:89920650 WDR51B 0.59 10.22 0.49 1.69e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6500602 0.893 rs4786489 chr16:4485527 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.53 6.72 0.35 7.91e-11 Schizophrenia; LUSC cis rs7605827 0.930 rs13002869 chr2:15674389 C/T cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.79e-17 Educational attainment (years of education); LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg24503407 chr1:205819492 PM20D1 0.9 16.83 0.68 1.82e-46 Menarche (age at onset); LUSC cis rs11190604 1.000 rs2489051 chr10:102351785 C/T cg16342193 chr10:102329863 NA 0.31 5.78 0.3 1.67e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.27 -0.49 1.08e-21 Gut microbiome composition (summer); LUSC cis rs1035144 0.524 rs8009260 chr14:81408591 G/T cg06600135 chr14:81408086 NA 0.54 8.26 0.41 3.51e-15 Male sexual orientation; LUSC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg07424592 chr7:64974309 NA -0.65 -5.85 -0.3 1.19e-8 Diabetic kidney disease; LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.47 6.36 0.33 6.79e-10 Renal function-related traits (BUN); LUSC cis rs6977660 0.619 rs10263780 chr7:19778086 A/G cg07541023 chr7:19748670 TWISTNB -0.68 -7.54 -0.38 4.62e-13 Thyroid stimulating hormone; LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs7647973 1.000 rs7648995 chr3:49438803 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.46 -6.99 -0.36 1.53e-11 Menarche (age at onset); LUSC cis rs826838 0.935 rs1843639 chr12:39178919 C/A cg26384229 chr12:38710491 ALG10B 0.89 16.91 0.68 8.9e-47 Heart rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15535636 chr19:41284070 RAB4B -0.4 -6.09 -0.32 3.14e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6964587 0.967 rs13233496 chr7:91813035 T/C cg17063962 chr7:91808500 NA 0.57 8.88 0.44 4.09e-17 Breast cancer; LUSC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg05253716 chr12:129299332 SLC15A4;MGC16384 -0.45 -6.71 -0.34 8.25e-11 Systemic lupus erythematosus; LUSC cis rs8060686 0.641 rs9932251 chr16:68131732 G/A cg26727032 chr16:67993705 SLC12A4 -0.42 -5.79 -0.3 1.62e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs2070488 0.965 rs2284819 chr3:38557161 C/T cg24069376 chr3:38537580 EXOG 0.47 9.34 0.45 1.44e-18 Electrocardiographic conduction measures; LUSC cis rs1577917 0.917 rs35038582 chr6:86721305 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.77e-10 Response to antipsychotic treatment; LUSC trans rs7726839 0.574 rs11134148 chr5:637107 C/T cg11887960 chr12:57824829 NA 0.53 6.58 0.34 1.83e-10 Obesity-related traits; LUSC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.39 -7.85 -0.39 5.8e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg23630131 chr7:65973040 NA 0.21 5.83 0.3 1.33e-8 Aortic root size; LUSC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg06028605 chr16:24865363 SLC5A11 -0.58 -9.57 -0.46 2.51e-19 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.720 rs1415968 chr1:152970219 C/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.79 -0.39 8.81e-14 Inflammatory skin disease; LUSC cis rs8016982 0.674 rs3815953 chr14:81685482 G/A cg01989461 chr14:81687754 GTF2A1 0.72 12.92 0.58 3.13e-31 Schizophrenia; LUSC cis rs12410462 0.710 rs74140145 chr1:227423946 C/T cg23173402 chr1:227635558 NA 0.47 5.9 0.31 8.93e-9 Major depressive disorder; LUSC trans rs7939886 0.920 rs74699881 chr11:55913852 A/T cg03929089 chr4:120376271 NA 0.75 5.95 0.31 6.62e-9 Myopia (pathological); LUSC trans rs7615952 0.932 rs7629977 chr3:125649573 T/G cg07211511 chr3:129823064 LOC729375 -1.26 -20.3 -0.74 3.11e-60 Blood pressure (smoking interaction); LUSC cis rs1670533 0.872 rs13108222 chr4:1054256 C/A cg27284194 chr4:1044797 NA 0.59 8.84 0.44 5.65e-17 Recombination rate (females); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg06620269 chr17:2952258 NA -0.46 -6.16 -0.32 2.12e-9 Hepatitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01916762 chr5:59996028 DEPDC1B -0.41 -6.12 -0.32 2.66e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.95 -0.36 1.95e-11 Mean platelet volume; LUSC cis rs13006833 0.668 rs2582746 chr2:191163784 T/C cg21644426 chr2:191273491 MFSD6 0.44 6.31 0.33 8.8e-10 Urinary metabolites; LUSC cis rs7511006 0.859 rs7292228 chr22:50649560 C/G cg07895657 chr22:50616420 PANX2 -0.36 -6.1 -0.32 2.94e-9 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27612695 chr17:29059191 SUZ12P 0.45 6.85 0.35 3.59e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9361491 0.543 rs1507153 chr6:79484386 C/A cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.06 -0.31 3.66e-9 Intelligence (multi-trait analysis); LUSC cis rs12681287 0.547 rs9942793 chr8:87509091 C/T cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03264133 chr6:25882463 NA -0.55 -9.08 -0.45 9.43e-18 Intelligence (multi-trait analysis); LUSC cis rs2932538 1.000 rs2932538 chr1:113216543 A/G cg22162597 chr1:113214053 CAPZA1 -0.68 -9.7 -0.47 9.01e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg18252515 chr7:66147081 NA -1.19 -12.84 -0.57 5.85e-31 Diabetic kidney disease; LUSC cis rs2637266 0.599 rs846574 chr10:78503082 G/A cg18941641 chr10:78392320 NA 0.39 7.04 0.36 1.09e-11 Pulmonary function; LUSC trans rs877282 0.853 rs12777155 chr10:754731 G/C cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC trans rs72674100 1.000 rs17026349 chr4:97979935 A/C cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19596991 chr10:126432951 FAM53B -0.42 -6.5 -0.34 2.95e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg18904891 chr8:8559673 CLDN23 0.56 7.58 0.38 3.53e-13 Obesity-related traits; LUSC cis rs9473147 0.543 rs9296559 chr6:47452270 T/C cg20196966 chr6:47445060 CD2AP 0.42 5.94 0.31 7.29e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs2439831 0.867 rs2255440 chr15:43830467 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.83 9.29 0.45 2.02e-18 Lung cancer in ever smokers; LUSC cis rs10845606 1.000 rs10845609 chr12:12838920 T/A cg04607235 chr12:12878440 APOLD1 -0.47 -5.65 -0.3 3.49e-8 Systemic lupus erythematosus; LUSC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.23 -0.32 1.39e-9 Neutrophil percentage of white cells; LUSC cis rs2979489 0.891 rs2915625 chr8:30382651 G/A cg26383811 chr8:30366931 RBPMS -0.53 -8.16 -0.41 6.95e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg05658215 chr7:157211628 NA 0.32 5.86 0.31 1.13e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs9914988 1.000 rs9914988 chr17:27183104 G/A cg19789473 chr17:27170043 C17orf63 0.31 6.19 0.32 1.79e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs926938 0.563 rs360635 chr1:115420518 A/C cg01522456 chr1:115632236 TSPAN2 -0.38 -5.77 -0.3 1.82e-8 Autism; LUSC cis rs992157 0.965 rs13427681 chr2:219167563 G/C cg00012203 chr2:219082015 ARPC2 0.81 14.0 0.61 2.22e-35 Colorectal cancer; LUSC cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg17691542 chr6:26056736 HIST1H1C 0.49 7.7 0.39 1.53e-13 Height; LUSC cis rs34172651 0.917 rs1465422 chr16:24772486 C/T cg00339695 chr16:24857497 SLC5A11 0.37 6.65 0.34 1.23e-10 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.692 rs55676827 chr15:76961716 C/T cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.29e-12 Blood metabolite levels; LUSC cis rs9467773 1.000 rs10214634 chr6:26564582 T/A cg09904177 chr6:26538194 HMGN4 0.76 14.13 0.61 7.08e-36 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.789 rs6076347 chr20:25398790 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.76 -15.01 -0.63 2.89e-39 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.56 0.34 2.01e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs62238980 0.614 rs79592323 chr22:32442742 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs7072216 0.763 rs6584204 chr10:100173580 C/G cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs2933343 0.700 rs1683777 chr3:128624880 T/G cg11901034 chr3:128598214 ACAD9 -0.42 -6.66 -0.34 1.16e-10 IgG glycosylation; LUSC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg22535103 chr8:58192502 C8orf71 -0.71 -7.44 -0.38 8.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg06784218 chr1:46089804 CCDC17 0.48 9.3 0.45 1.9e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs644799 0.932 rs523934 chr11:95641775 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.72 10.72 0.51 3.17e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs12908161 0.959 rs1051168 chr15:85200520 G/T cg12863693 chr15:85201151 NMB 0.41 8.44 0.42 9.94e-16 Schizophrenia; LUSC cis rs9905704 0.681 rs2531728 chr17:56539792 T/C cg19466818 chr17:56409534 MIR142 -0.35 -6.52 -0.34 2.53e-10 Testicular germ cell tumor; LUSC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.84 -10.97 -0.51 4.07e-24 Schizophrenia; LUSC cis rs12997796 0.556 rs34933869 chr2:86922397 T/C cg25203885 chr2:87302643 LOC285074 -0.81 -8.39 -0.42 1.42e-15 Schizophrenia; LUSC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.32 -0.41 2.29e-15 Personality dimensions; LUSC cis rs752010 0.806 rs11210500 chr1:42089737 A/G cg06885757 chr1:42089581 HIVEP3 0.53 11.34 0.53 1.88e-25 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Vitiligo; LUSC cis rs870825 0.549 rs7656993 chr4:185635159 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.19 0.59 2.82e-32 Blood protein levels; LUSC cis rs6732160 0.619 rs12105975 chr2:73406049 T/A cg24220031 chr2:73402428 NA -0.23 -5.66 -0.3 3.26e-8 Intelligence (multi-trait analysis); LUSC cis rs897984 0.762 rs12930545 chr16:30938811 A/G cg02466173 chr16:30829666 NA 0.56 11.25 0.52 4.19e-25 Dementia with Lewy bodies; LUSC cis rs12594515 1.000 rs8031128 chr15:45988528 C/G cg19682013 chr15:45996608 NA 0.39 6.0 0.31 5.09e-9 Waist circumference;Weight; LUSC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg02221750 chr19:17393354 ANKLE1 -0.91 -13.72 -0.6 2.84e-34 Systemic lupus erythematosus; LUSC cis rs1790761 0.607 rs656652 chr11:67343957 C/T cg00864171 chr11:67383662 NA 0.35 6.15 0.32 2.26e-9 Mean corpuscular volume; LUSC cis rs9287719 0.578 rs10168852 chr2:10746323 C/A cg00105475 chr2:10696890 NA 0.35 5.8 0.3 1.55e-8 Prostate cancer; LUSC cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg24692254 chr21:30365293 RNF160 -0.79 -14.42 -0.62 5.61e-37 Dental caries; LUSC cis rs11018874 0.597 rs4393275 chr11:89886397 C/T cg14505434 chr11:89522851 NA 0.38 6.05 0.31 3.93e-9 White blood cell types; LUSC cis rs137603 0.603 rs137581 chr22:39677838 C/T cg17798944 chr22:39715225 SNORD43;RPL3 -0.51 -7.97 -0.4 2.62e-14 Primary biliary cholangitis; LUSC cis rs9807989 0.571 rs10208293 chr2:102966310 G/A cg09003973 chr2:102972529 NA 0.47 5.9 0.31 9.15e-9 Asthma; LUSC cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg26647111 chr11:31128758 NA -0.42 -6.09 -0.32 3.12e-9 Red blood cell count; LUSC cis rs7255 0.538 rs2289081 chr2:20881840 G/C cg05481257 chr2:20870211 GDF7 -0.34 -5.74 -0.3 2.18e-8 Barrett's esophagus or Esophageal adenocarcinoma;Esophageal adenocarcinoma; LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13126279 chr21:47581558 C21orf56 0.57 8.75 0.43 1.08e-16 Testicular germ cell tumor; LUSC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg08470875 chr2:26401718 FAM59B -0.66 -8.63 -0.43 2.55e-16 Gut microbiome composition (summer); LUSC cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg00631329 chr6:26305371 NA -0.48 -9.09 -0.45 9.17e-18 Educational attainment; LUSC trans rs61931739 0.534 rs2087128 chr12:34000173 T/C cg26384229 chr12:38710491 ALG10B 0.68 10.62 0.5 6.6e-23 Morning vs. evening chronotype; LUSC cis rs7223966 1.000 rs7223412 chr17:61808172 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.92 0.35 2.31e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.83 -0.35 3.95e-11 Mean platelet volume; LUSC trans rs800082 1.000 rs9882503 chr3:144321296 A/T cg24215973 chr2:240111563 HDAC4 -0.46 -7.03 -0.36 1.19e-11 Smoking behavior; LUSC cis rs4919694 1.000 rs12241091 chr10:104808997 G/A cg04362960 chr10:104952993 NT5C2 1.18 13.93 0.61 4.45e-35 Arsenic metabolism; LUSC cis rs4629180 0.675 rs10184144 chr2:102104978 C/T cg01388757 chr2:102091195 RFX8 -0.36 -6.25 -0.32 1.24e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs76248362 1.000 rs4770506 chr13:24434703 T/C cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg26384229 chr12:38710491 ALG10B 0.95 17.42 0.69 8.24e-49 Heart rate; LUSC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg03433033 chr1:76189801 ACADM 0.82 14.81 0.63 1.76e-38 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7072216 0.763 rs8181292 chr10:100175477 A/G cg19567339 chr10:100142640 NA 0.38 5.79 0.3 1.59e-8 Metabolite levels; LUSC cis rs9359856 0.564 rs7754145 chr6:90283237 C/T cg13799429 chr6:90582589 CASP8AP2 0.47 5.97 0.31 6.09e-9 Bipolar disorder; LUSC cis rs11048434 0.698 rs7300767 chr12:9123477 T/G cg23795048 chr12:9217529 LOC144571 0.34 5.8 0.3 1.51e-8 Sjögren's syndrome; LUSC cis rs9325144 0.600 rs1817648 chr12:38733424 C/T cg13010199 chr12:38710504 ALG10B -0.47 -7.25 -0.37 2.99e-12 Morning vs. evening chronotype; LUSC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21659725 chr3:3221576 CRBN -0.89 -18.59 -0.71 1.87e-53 Intelligence (multi-trait analysis); LUSC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.59 -7.22 -0.37 3.49e-12 Lung function (FEV1/FVC); LUSC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg23791538 chr6:167370224 RNASET2 -0.37 -5.88 -0.31 9.78e-9 Crohn's disease; LUSC cis rs3768617 0.510 rs1413387 chr1:183096774 G/A ch.1.3577855R chr1:183094577 LAMC1 0.73 11.17 0.52 8.24e-25 Fuchs's corneal dystrophy; LUSC cis rs4820539 1.000 rs6003518 chr22:23471533 C/T cg21100191 chr22:23484243 RTDR1 0.91 16.0 0.66 3.71e-43 Bone mineral density; LUSC cis rs478304 0.593 rs2236682 chr11:65480090 G/T cg05805236 chr11:65401703 PCNXL3 -0.62 -10.03 -0.48 7.38e-21 Acne (severe); LUSC cis rs9646944 0.501 rs3213733 chr2:102997884 C/A cg20060108 chr2:102954350 IL1RL1 0.47 6.32 0.33 8.2e-10 Blood protein levels; LUSC cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg07606381 chr6:8435919 SLC35B3 0.75 12.61 0.57 4.55e-30 Motion sickness; LUSC cis rs877282 0.583 rs11253429 chr10:823234 A/C cg13775593 chr10:823151 NA 0.31 6.06 0.31 3.75e-9 Uric acid levels; LUSC cis rs2236918 1.000 rs2236919 chr1:242017731 A/G cg17736920 chr1:242011382 EXO1 0.45 7.12 0.36 6.71e-12 Menopause (age at onset); LUSC cis rs1348850 0.632 rs4470372 chr2:178505857 G/A cg22681709 chr2:178499509 PDE11A -0.6 -12.07 -0.55 4.52e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg04287289 chr16:89883240 FANCA 0.41 6.0 0.31 5.22e-9 Vitiligo; LUSC cis rs16854884 0.657 rs10513235 chr3:143698664 T/C cg06585982 chr3:143692056 C3orf58 0.45 6.81 0.35 4.66e-11 Economic and political preferences (feminism/equality); LUSC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.84 0.3 1.25e-8 Tonsillectomy; LUSC cis rs877282 1.000 rs112522746 chr10:772288 T/C cg17470449 chr10:769945 NA 0.51 7.07 0.36 9.06e-12 Uric acid levels; LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg09324608 chr17:30823087 MYO1D 0.35 5.68 0.3 2.99e-8 Schizophrenia; LUSC cis rs6499755 0.965 rs9888978 chr16:55352984 T/G cg02859129 chr16:55357253 IRX6 0.35 5.9 0.31 8.94e-9 Hypospadias; LUSC cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.61 -0.34 1.51e-10 Arsenic metabolism; LUSC cis rs6089584 0.507 rs6061990 chr20:60628429 T/G cg24733560 chr20:60626293 TAF4 0.42 7.68 0.39 1.74e-13 Body mass index; LUSC trans rs208520 1.000 rs72882079 chr6:66973878 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 12.22 0.56 1.23e-28 Exhaled nitric oxide output; LUSC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg11941060 chr3:133502564 NA -0.43 -6.19 -0.32 1.75e-9 Iron status biomarkers; LUSC cis rs713477 0.654 rs61976568 chr14:55906218 A/G cg13175173 chr14:55914753 NA -0.31 -6.2 -0.32 1.65e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs2637266 0.756 rs846623 chr10:78542819 C/T cg18941641 chr10:78392320 NA 0.39 6.99 0.36 1.54e-11 Pulmonary function; LUSC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg17554472 chr22:41940697 POLR3H -0.48 -5.87 -0.31 1.05e-8 Vitiligo; LUSC cis rs12579753 0.917 rs10778833 chr12:82197983 G/T cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs6494488 0.500 rs72744739 chr15:65049926 T/C cg08069370 chr15:64387884 SNX1 -0.65 -5.91 -0.31 8.23e-9 Coronary artery disease; LUSC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg13393036 chr8:95962371 TP53INP1 -0.5 -10.82 -0.51 1.32e-23 Type 2 diabetes; LUSC cis rs765787 0.530 rs12439643 chr15:45529767 A/G cg25801113 chr15:45476975 SHF -0.33 -6.7 -0.34 8.73e-11 Uric acid levels; LUSC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg24531977 chr5:56204891 C5orf35 -1.01 -15.01 -0.63 2.75e-39 Initial pursuit acceleration; LUSC cis rs240764 0.621 rs9404052 chr6:101249718 T/C cg09795085 chr6:101329169 ASCC3 -0.46 -6.65 -0.34 1.2e-10 Neuroticism; LUSC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs57590327 0.503 rs6764261 chr3:81620370 T/G cg07356753 chr3:81810745 GBE1 -0.48 -6.51 -0.34 2.79e-10 Extraversion; LUSC cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg26384229 chr12:38710491 ALG10B 0.81 14.05 0.61 1.44e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg04518342 chr5:131593106 PDLIM4 -0.32 -5.99 -0.31 5.41e-9 Blood metabolite levels; LUSC trans rs11039798 0.614 rs8188910 chr11:48825740 C/T cg15704280 chr7:45808275 SEPT13 0.78 7.46 0.38 7.71e-13 Axial length; LUSC cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.21 0.49 1.83e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg21280719 chr6:42927975 GNMT -0.26 -5.71 -0.3 2.44e-8 Blood protein levels; LUSC cis rs9902453 0.619 rs2617866 chr17:28076217 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.74 -0.51 2.54e-23 Coffee consumption (cups per day); LUSC trans rs564343 0.688 rs539046 chr11:65843778 A/T cg26701943 chr11:108369231 KDELC2 -0.44 -6.24 -0.32 1.34e-9 Obesity (early onset extreme); LUSC cis rs10782582 0.609 rs1630587 chr1:76399787 T/C cg03433033 chr1:76189801 ACADM -0.39 -5.89 -0.31 9.48e-9 Daytime sleep phenotypes; LUSC cis rs7917772 0.560 rs7912339 chr10:104373758 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.08 0.52 1.68e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.07 -0.48 5.32e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9815354 0.761 rs57638657 chr3:41809238 G/C cg03022575 chr3:42003672 ULK4 0.83 8.34 0.41 2.04e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11890956 chr21:40555474 PSMG1 1.04 21.25 0.76 5.24e-64 Cognitive function; LUSC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.4 -7.98 -0.4 2.3e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg03475776 chr2:240114298 HDAC4 0.38 6.54 0.34 2.32e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs877282 0.898 rs12358513 chr10:757571 A/G cg22713356 chr15:30763199 NA 1.03 13.61 0.6 7.56e-34 Uric acid levels; LUSC cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg00083206 chr6:110721305 DDO 0.42 7.61 0.38 2.82e-13 Platelet distribution width; LUSC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs2180341 0.814 rs6919082 chr6:127737888 T/G cg24812749 chr6:127587940 RNF146 0.73 10.51 0.5 1.66e-22 Breast cancer; LUSC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg24675658 chr1:53192096 ZYG11B -0.65 -10.03 -0.48 7.31e-21 Monocyte count; LUSC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC cis rs17253792 0.822 rs75016910 chr14:56050466 C/G cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs1775715 0.737 rs2799015 chr10:32107712 C/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.67 0.39 1.89e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs17092148 0.731 rs35507767 chr20:33361364 A/T cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg04315214 chr1:2043799 PRKCZ 0.46 9.52 0.46 3.7e-19 Height; LUSC cis rs240764 0.604 rs9377234 chr6:101263035 C/T cg09795085 chr6:101329169 ASCC3 0.44 6.24 0.32 1.35e-9 Neuroticism; LUSC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg11764359 chr7:65958608 NA 0.62 9.47 0.46 5.16e-19 Calcium levels; LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC cis rs34734847 0.965 rs2005455 chr12:121128699 A/G cg21892295 chr12:121157589 UNC119B -0.46 -8.26 -0.41 3.46e-15 Mean corpuscular volume; LUSC cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg00012203 chr2:219082015 ARPC2 0.6 10.08 0.48 5.07e-21 Ulcerative colitis; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.14 0.52 9.97e-25 Prudent dietary pattern; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg25703541 chr22:24373054 LOC391322 -0.87 -14.04 -0.61 1.57e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg23711669 chr6:146136114 FBXO30 -0.77 -12.37 -0.56 3.54e-29 Lobe attachment (rater-scored or self-reported); LUSC trans rs6502050 0.835 rs4789754 chr17:80091941 C/T cg07393940 chr7:158741817 NA 0.37 6.85 0.35 3.56e-11 Life satisfaction; LUSC cis rs2832077 0.943 rs11700746 chr21:30189207 T/C cg24692254 chr21:30365293 RNF160 -0.58 -7.22 -0.37 3.57e-12 Cognitive test performance; LUSC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg25767906 chr1:53392781 SCP2 -0.51 -9.28 -0.45 2.23e-18 Monocyte count; LUSC cis rs734999 0.545 rs9970196 chr1:2574078 T/C cg18854424 chr1:2615690 NA -0.5 -9.91 -0.48 1.85e-20 Ulcerative colitis; LUSC cis rs1461503 0.966 rs7113725 chr11:122843511 G/T cg27398637 chr11:122830231 C11orf63 -0.4 -6.5 -0.34 2.93e-10 Menarche (age at onset); LUSC cis rs34638657 0.702 rs12599946 chr16:82199831 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.55e-10 Lung adenocarcinoma; LUSC cis rs12753569 0.934 rs6676370 chr1:76490185 G/T cg00791851 chr1:76518896 NA -0.32 -6.19 -0.32 1.75e-9 Personality dimensions; LUSC cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.39 0.56 2.99e-29 Motion sickness; LUSC cis rs2294693 0.945 rs9369252 chr6:40986028 C/T cg14769373 chr6:40998127 UNC5CL 0.54 7.37 0.37 1.36e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2976388 1.000 rs2294010 chr8:143762430 A/G cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC trans rs6952808 0.792 rs12531315 chr7:1953650 C/G cg04565464 chr8:145669602 NFKBIL2 0.38 6.15 0.32 2.21e-9 Bipolar disorder and schizophrenia; LUSC cis rs9837602 1.000 rs7610486 chr3:99732564 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.22 -0.32 1.5e-9 Breast cancer; LUSC cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg01483505 chr11:975446 AP2A2 0.42 5.91 0.31 8.68e-9 Alzheimer's disease (late onset); LUSC cis rs6736093 1.000 rs11673729 chr2:112665961 T/A cg12686935 chr2:112915763 FBLN7 -0.36 -5.77 -0.3 1.86e-8 Coronary artery disease; LUSC cis rs3772130 1.000 rs13087578 chr3:121369207 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.65 9.54 0.46 3.2e-19 Cognitive performance; LUSC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg20243544 chr17:37824526 PNMT 0.42 6.48 0.33 3.38e-10 Self-reported allergy; LUSC cis rs11677416 0.961 rs3783557 chr2:113530712 C/T cg27083787 chr2:113543245 IL1A 0.47 7.07 0.36 9.09e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg08085267 chr17:45401833 C17orf57 -0.55 -8.32 -0.41 2.29e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4363385 0.667 rs756303 chr1:152908222 C/T cg00922841 chr1:152955080 SPRR1A -0.4 -6.81 -0.35 4.48e-11 Inflammatory skin disease; LUSC cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg16586182 chr3:47516702 SCAP -0.52 -8.13 -0.41 8.41e-15 Colorectal cancer; LUSC cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg04450456 chr4:17643702 FAM184B 0.41 6.98 0.36 1.62e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -16.28 -0.67 2.76e-44 Monocyte count; LUSC cis rs6570726 0.967 rs418662 chr6:145848832 A/C cg05347473 chr6:146136440 FBXO30 0.38 6.3 0.33 9.48e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg22437258 chr11:111473054 SIK2 0.51 7.02 0.36 1.25e-11 Primary sclerosing cholangitis; LUSC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg07701084 chr6:150067640 NUP43 0.49 7.36 0.37 1.42e-12 Lung cancer; LUSC cis rs826838 0.935 rs7301104 chr12:39182821 C/T cg26384229 chr12:38710491 ALG10B 0.89 16.94 0.68 7.06e-47 Heart rate; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg15242686 chr22:24348715 GSTTP1 0.4 5.98 0.31 5.7e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg10018233 chr7:150070692 REPIN1 -0.39 -7.08 -0.36 8.51e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC cis rs372883 0.597 rs2018956 chr21:30736622 C/A cg24692254 chr21:30365293 RNF160 0.53 7.75 0.39 1.1e-13 Pancreatic cancer; LUSC cis rs2455601 0.935 rs12049908 chr11:8919309 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -7.86 -0.4 5.21e-14 Schizophrenia; LUSC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.63 -10.26 -0.49 1.15e-21 Menarche (age at onset); LUSC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg20276088 chr3:133502917 NA -0.41 -6.02 -0.31 4.6e-9 Iron status biomarkers; LUSC cis rs2295359 1.000 rs963427 chr1:67609347 A/G cg12940439 chr1:67600707 NA 0.38 6.31 0.33 8.62e-10 Psoriasis; LUSC cis rs858239 0.601 rs1558313 chr7:23156079 G/A cg23682824 chr7:23144976 KLHL7 0.39 5.68 0.3 2.92e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs12586317 0.548 rs12590678 chr14:35602956 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -6.37 -0.33 6.19e-10 Psoriasis; LUSC cis rs4776059 1.000 rs11070909 chr15:52931601 A/G cg22715398 chr15:52968154 KIAA1370 -0.63 -8.94 -0.44 2.75e-17 Schizophrenia; LUSC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg05535760 chr7:792225 HEATR2 -0.74 -7.41 -0.38 1.01e-12 Cerebrospinal P-tau181p levels; LUSC cis rs78773383 0.505 rs13123782 chr4:39377405 A/C cg12062995 chr4:39368212 RFC1 0.41 6.17 0.32 1.94e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7071206 0.704 rs11002234 chr10:79434458 A/G cg07817648 chr10:79422355 NA -0.44 -5.8 -0.3 1.51e-8 Bone mineral density; LUSC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg04369109 chr6:150039330 LATS1 -0.54 -8.03 -0.4 1.7e-14 Lung cancer; LUSC cis rs61931739 0.534 rs11053075 chr12:34207009 A/G cg06521331 chr12:34319734 NA 0.45 7.43 0.38 9.19e-13 Morning vs. evening chronotype; LUSC cis rs13082711 0.911 rs34307140 chr3:27467875 A/C cg02860705 chr3:27208620 NA 0.5 8.41 0.42 1.2e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs1922233 0.891 rs9307096 chr4:92411848 C/G cg24250684 chr1:219729030 NA -0.32 -6.19 -0.32 1.74e-9 Gut microbiome composition (summer and winter); LUSC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg04414720 chr1:150670196 GOLPH3L 0.54 8.63 0.43 2.56e-16 Tonsillectomy; LUSC cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg23711669 chr6:146136114 FBXO30 0.72 12.63 0.57 3.85e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg18765753 chr7:1198926 ZFAND2A -0.34 -5.79 -0.3 1.6e-8 Longevity;Endometriosis; LUSC cis rs240764 0.658 rs9390681 chr6:101218994 A/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.26 -0.32 1.19e-9 Neuroticism; LUSC cis rs1044826 1.000 rs34623690 chr3:139194385 A/G cg00490450 chr3:139108681 COPB2 0.52 6.78 0.35 5.37e-11 Obesity-related traits; LUSC cis rs7659604 0.643 rs6839375 chr4:122663610 G/C cg19748678 chr4:122722346 EXOSC9 0.47 6.32 0.33 8.18e-10 Type 2 diabetes; LUSC cis rs11105298 0.891 rs4842662 chr12:89933446 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.21 -0.37 3.73e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13909320 chr9:125026858 MRRF;RBM18 -0.44 -6.0 -0.31 5.13e-9 Bipolar disorder and schizophrenia; LUSC cis rs262150 0.522 rs2527182 chr7:158813812 A/G cg09826364 chr7:158789723 NA -0.38 -5.91 -0.31 8.56e-9 Facial morphology (factor 20); LUSC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg20933634 chr6:27740509 NA -0.44 -5.93 -0.31 7.7e-9 Parkinson's disease; LUSC cis rs7246967 0.551 rs35740274 chr19:22831413 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.94 0.35 2.09e-11 Bronchopulmonary dysplasia; LUSC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg12379764 chr21:47803548 PCNT -0.45 -6.29 -0.33 9.94e-10 Testicular germ cell tumor; LUSC trans rs11098499 0.954 rs28572238 chr4:120316686 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.02 0.31 4.65e-9 Corneal astigmatism; LUSC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg20406979 chr6:167373233 NA 0.26 6.19 0.32 1.73e-9 Crohn's disease; LUSC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg08085267 chr17:45401833 C17orf57 -0.55 -8.34 -0.42 2e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg22782873 chr19:19639568 YJEFN3 0.53 6.45 0.33 3.94e-10 Bipolar disorder; LUSC cis rs983392 0.679 rs7121656 chr11:60024008 C/T cg24026212 chr11:59952134 MS4A6A 0.38 6.64 0.34 1.24e-10 Alzheimer's disease (late onset); LUSC cis rs10465746 0.714 rs12730621 chr1:84433745 C/G cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 9.94e-10 Obesity-related traits; LUSC cis rs11148252 0.574 rs9536247 chr13:53279542 T/C cg02158880 chr13:53174818 NA 0.58 10.42 0.5 3.39e-22 Lewy body disease; LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg16647868 chr5:131706066 SLC22A5 0.38 5.97 0.31 6e-9 Breast cancer; LUSC cis rs4499344 0.730 rs10413061 chr19:33103278 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs796364 0.616 rs2689765 chr2:200696352 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.53 6.24 0.32 1.31e-9 Schizophrenia; LUSC cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.14 0.32 2.33e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg13010199 chr12:38710504 ALG10B 0.61 9.55 0.46 2.89e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs8022179 0.580 rs6575979 chr14:103841018 A/G cg12935359 chr14:103987150 CKB -0.6 -8.3 -0.41 2.53e-15 Monocyte count; LUSC trans rs208520 0.770 rs1342960 chr6:66883514 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -15.19 -0.64 5.5e-40 Exhaled nitric oxide output; LUSC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg26039829 chr8:22132926 PIWIL2 0.44 8.12 0.41 9.21e-15 Hypertriglyceridemia; LUSC cis rs1506636 1.000 rs2402671 chr7:123355483 T/C cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs12541635 0.801 rs12155859 chr8:107105384 C/T cg10147462 chr8:107024639 NA -0.45 -7.99 -0.4 2.18e-14 Age of smoking initiation; LUSC cis rs11039100 0.573 rs34335913 chr11:5793979 C/T cg13902645 chr11:5959945 NA -0.53 -5.82 -0.3 1.39e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg15839431 chr19:19639596 YJEFN3 0.43 6.1 0.32 2.86e-9 Tonsillectomy; LUSC cis rs17604090 0.793 rs10241305 chr7:29689929 T/C cg19413766 chr7:29689036 LOC646762 -0.56 -7.08 -0.36 8.41e-12 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg22800045 chr5:56110881 MAP3K1 0.46 6.17 0.32 1.96e-9 Coronary artery disease; LUSC cis rs12477438 0.765 rs6542846 chr2:99563654 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.08 -0.4 1.16e-14 Chronic sinus infection; LUSC cis rs7215564 0.908 rs35584560 chr17:78668256 G/A cg23238734 chr17:78661607 RPTOR 0.49 6.43 0.33 4.46e-10 Myopia (pathological); LUSC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg04414720 chr1:150670196 GOLPH3L 0.5 7.73 0.39 1.24e-13 Melanoma; LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg08742575 chr21:47604166 C21orf56 -0.48 -7.25 -0.37 2.89e-12 Testicular germ cell tumor; LUSC cis rs6076065 0.723 rs4813493 chr20:23367373 G/C cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC trans rs877282 0.945 rs11253396 chr10:789754 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs3806843 0.933 rs2337987 chr5:140188383 T/G cg19875535 chr5:140030758 IK 0.47 7.52 0.38 5.19e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs4704187 0.687 rs7720620 chr5:74366023 A/G cg03227963 chr5:74354835 NA 0.33 7.02 0.36 1.27e-11 Response to amphetamines; LUSC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg06637938 chr14:75390232 RPS6KL1 0.54 8.76 0.43 9.83e-17 Height; LUSC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg21573476 chr21:45109991 RRP1B -0.36 -5.69 -0.3 2.74e-8 Mean corpuscular volume; LUSC cis rs3862030 0.720 rs11593971 chr10:104234090 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.59 -9.23 -0.45 3.19e-18 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs1044826 0.667 rs295471 chr3:139213922 G/C cg00490450 chr3:139108681 COPB2 0.46 7.03 0.36 1.19e-11 Obesity-related traits; LUSC cis rs427941 0.585 rs201511 chr7:101767653 A/G cg06246474 chr7:101738831 CUX1 0.38 6.25 0.32 1.26e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs1595825 0.891 rs16826895 chr2:198901642 A/G cg10547527 chr2:198650123 BOLL -0.53 -6.24 -0.32 1.34e-9 Ulcerative colitis; LUSC cis rs7954584 0.626 rs12809676 chr12:122442381 C/A cg13699009 chr12:122356056 WDR66 0.46 6.93 0.35 2.24e-11 Mean corpuscular volume; LUSC cis rs9640161 0.636 rs3735171 chr7:150033882 A/G cg27494647 chr7:150038898 RARRES2 0.53 8.05 0.4 1.46e-14 Blood protein levels;Circulating chemerin levels; LUSC trans rs12210905 0.688 rs12212348 chr6:27361242 T/C cg11837749 chr1:55047332 ACOT11 0.68 6.07 0.32 3.38e-9 Hip circumference adjusted for BMI; LUSC trans rs3733585 0.673 rs6850143 chr4:9958924 T/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25818522 chr17:25621101 WSB1 0.72 6.14 0.32 2.28e-9 Cognitive performance; LUSC cis rs17270561 0.525 rs10484432 chr6:26008876 G/A cg17691542 chr6:26056736 HIST1H1C 0.99 12.42 0.56 2.28e-29 Iron status biomarkers; LUSC cis rs921968 0.541 rs526897 chr2:219433597 C/T cg02176678 chr2:219576539 TTLL4 0.74 13.88 0.6 6.62e-35 Mean corpuscular hemoglobin concentration; LUSC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg02569458 chr12:86230093 RASSF9 0.46 7.49 0.38 6.2e-13 Major depressive disorder; LUSC cis rs2637266 0.846 rs2637263 chr10:78322442 G/A cg18941641 chr10:78392320 NA 0.38 6.99 0.36 1.49e-11 Pulmonary function; LUSC cis rs9814567 1.000 rs9841212 chr3:134191938 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -5.89 -0.31 9.44e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9287719 0.967 rs4669596 chr2:10720572 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.96e-9 Prostate cancer; LUSC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3749237 0.964 rs2352967 chr3:49871641 C/T cg05072774 chr3:49840536 C3orf54 -0.43 -5.93 -0.31 7.5e-9 Resting heart rate; LUSC cis rs637571 0.544 rs56239996 chr11:65730003 A/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.46 6.68 0.34 1.02e-10 Eosinophil percentage of white cells; LUSC cis rs9715521 0.588 rs11731207 chr4:59852246 G/A cg11281224 chr4:60001000 NA -0.5 -6.92 -0.35 2.28e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7929679 0.551 rs10836303 chr11:34792702 T/C cg06937548 chr11:34938143 PDHX;APIP 0.4 5.91 0.31 8.29e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs877282 0.838 rs11253374 chr10:774961 C/T cg17470449 chr10:769945 NA 0.55 7.8 0.39 7.79e-14 Uric acid levels; LUSC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg03264133 chr6:25882463 NA -0.4 -7.08 -0.36 8.34e-12 Height; LUSC cis rs1065852 0.503 rs9620006 chr22:42399547 T/A cg22189786 chr22:42395067 WBP2NL 0.43 5.77 0.3 1.84e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg26818010 chr10:134567672 INPP5A -0.86 -11.07 -0.52 1.83e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs7819412 0.749 rs11991118 chr8:10939273 A/C cg06636001 chr8:8085503 FLJ10661 0.47 7.05 0.36 1.06e-11 Triglycerides; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14043925 chr11:3013809 NAP1L4 0.47 6.37 0.33 6.37e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10425738 0.536 rs10426903 chr19:41417719 T/C cg04176888 chr19:41596066 CYP2A13 0.39 6.72 0.35 7.63e-11 nicotine metabolite ratio in current smokers;Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio); LUSC cis rs1371867 0.875 rs28595052 chr8:101327553 G/A cg06002616 chr8:101225028 SPAG1 -0.45 -7.33 -0.37 1.72e-12 Atrioventricular conduction; LUSC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg23758822 chr17:41437982 NA 1.04 19.21 0.72 6.53e-56 Menopause (age at onset); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg27228074 chr10:104678015 CNNM2 0.44 6.22 0.32 1.5e-9 Calcium levels; LUSC cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg22875332 chr1:76189707 ACADM -0.39 -5.86 -0.31 1.1e-8 Daytime sleep phenotypes; LUSC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg10909506 chr17:38081995 ORMDL3 0.34 6.07 0.32 3.48e-9 Self-reported allergy; LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg08677398 chr8:58056175 NA -0.58 -7.5 -0.38 5.77e-13 Developmental language disorder (linguistic errors); LUSC trans rs2243480 0.901 rs2900904 chr7:65204264 C/G cg10756647 chr7:56101905 PSPH 0.83 8.14 0.41 8e-15 Diabetic kidney disease; LUSC cis rs1506636 1.000 rs7779099 chr7:123295964 C/T cg03229431 chr7:123269106 ASB15 -0.65 -10.62 -0.5 6.66e-23 Plateletcrit;Platelet count; LUSC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg06505273 chr16:24850292 NA 0.4 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis); LUSC cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg24812749 chr6:127587940 RNF146 0.92 13.87 0.6 7.61e-35 Breast cancer; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg11645453 chr3:52864694 ITIH4 -0.3 -7.24 -0.37 3.19e-12 Electroencephalogram traits; LUSC cis rs4919087 0.892 rs10882880 chr10:99008068 G/A cg25902810 chr10:99078978 FRAT1 0.46 6.72 0.35 7.68e-11 Monocyte count; LUSC cis rs6464929 0.955 rs13247593 chr7:148723269 A/G cg23583168 chr7:148888333 NA 0.46 5.76 0.3 1.94e-8 Pediatric bone mineral content (hip); LUSC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.1e-18 Menopause (age at onset); LUSC cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC cis rs72781680 0.898 rs72798041 chr2:23953076 T/C cg08917208 chr2:24149416 ATAD2B 0.99 9.9 0.48 1.94e-20 Lymphocyte counts; LUSC cis rs2625529 0.526 rs62022789 chr15:72564492 C/T cg16672083 chr15:72433130 SENP8 0.46 7.6 0.38 3.02e-13 Red blood cell count; LUSC trans rs7824557 0.767 rs7003241 chr8:11169075 A/G cg08975724 chr8:8085496 FLJ10661 0.45 6.68 0.34 1.03e-10 Retinal vascular caliber; LUSC cis rs12548874 0.607 rs12543492 chr8:95891843 C/A cg23172400 chr8:95962367 TP53INP1 -0.33 -6.69 -0.34 9.68e-11 Hemoglobin concentration; LUSC cis rs2075165 0.901 rs759329 chr1:156230936 A/G cg20302342 chr1:156215951 PAQR6 0.32 6.18 0.32 1.9e-9 Tonsillectomy; LUSC cis rs17401966 0.838 rs912963 chr1:10348042 C/T cg19773385 chr1:10388646 KIF1B -0.5 -8.73 -0.43 1.27e-16 Hepatocellular carcinoma; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13012494 chr21:47604986 C21orf56 -0.47 -7.18 -0.37 4.65e-12 Testicular germ cell tumor; LUSC cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg23788917 chr6:8435910 SLC35B3 0.51 7.58 0.38 3.38e-13 Motion sickness; LUSC trans rs11098499 0.691 rs9995716 chr4:120264996 T/C cg25214090 chr10:38739885 LOC399744 0.39 5.98 0.31 5.71e-9 Corneal astigmatism; LUSC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg11062466 chr8:58055876 NA 0.48 6.46 0.33 3.65e-10 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.32 0.56 5.39e-29 Chronic sinus infection; LUSC cis rs950169 0.922 rs11631096 chr15:85100929 G/C cg17507749 chr15:85114479 UBE2QP1 0.7 8.98 0.44 1.97e-17 Schizophrenia; LUSC cis rs11585357 0.895 rs72646797 chr1:17613838 C/G cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC cis rs3772130 1.000 rs34086988 chr3:121352745 G/C cg01951420 chr3:121553821 IQCB1;EAF2 0.66 9.61 0.47 1.77e-19 Cognitive performance; LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.771 rs9450319 chr6:86427325 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.51 8.11 0.41 9.65e-15 Response to antipsychotic treatment; LUSC cis rs3931020 0.962 rs2185695 chr1:75257881 T/C cg10128416 chr1:75198403 TYW3;CRYZ 0.42 5.69 0.3 2.84e-8 Resistin levels; LUSC cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC trans rs6601327 0.607 rs6992666 chr8:9586704 A/C cg15556689 chr8:8085844 FLJ10661 -0.45 -6.43 -0.33 4.34e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs644799 0.540 rs10831422 chr11:95478968 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.53 7.18 0.37 4.47e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9436747 0.510 rs12091826 chr1:66008158 A/T cg14976592 chr1:65886160 LEPROT;LEPR -0.44 -6.04 -0.31 4.18e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg11247378 chr22:39784982 NA -0.64 -12.72 -0.57 1.7e-30 Intelligence (multi-trait analysis); LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg07806771 chr7:64541737 NA 0.45 6.42 0.33 4.69e-10 Calcium levels; LUSC cis rs6920965 0.507 rs9385389 chr6:126215486 G/C cg10911889 chr6:126070802 HEY2 0.4 5.9 0.31 8.75e-9 High light scatter reticulocyte count; LUSC cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg23711669 chr6:146136114 FBXO30 0.85 15.25 0.64 3.1e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.09 -0.36 8.12e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg24110177 chr3:50126178 RBM5 0.57 9.53 0.46 3.46e-19 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.844 rs6050477 chr20:25221547 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.78 -15.83 -0.65 1.63e-42 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.2 0.37 4.12e-12 Mean platelet volume; LUSC cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.84 0.3 1.26e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg05340658 chr4:99064831 C4orf37 0.64 10.17 0.49 2.45e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11690935 0.879 rs908671 chr2:172690265 C/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.31 -0.62 1.45e-36 Schizophrenia; LUSC trans rs7939886 0.920 rs1482009 chr11:55884690 T/G cg15704280 chr7:45808275 SEPT13 0.82 6.77 0.35 5.73e-11 Myopia (pathological); LUSC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg22875332 chr1:76189707 ACADM -0.73 -10.1 -0.48 4.22e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg01256987 chr12:42539512 GXYLT1 -0.46 -8.84 -0.44 5.45e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg18099408 chr3:52552593 STAB1 -0.41 -6.9 -0.35 2.57e-11 Bipolar disorder; LUSC cis rs2732480 0.577 rs2634693 chr12:48706498 C/T cg04545296 chr12:48745243 ZNF641 0.37 6.78 0.35 5.33e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4919087 0.810 rs1468069 chr10:98988759 A/C cg25902810 chr10:99078978 FRAT1 0.43 6.36 0.33 6.69e-10 Monocyte count; LUSC trans rs62458065 0.850 rs28693551 chr7:32469387 G/A cg00845942 chr12:64062724 DPY19L2 -0.52 -6.11 -0.32 2.84e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7572644 0.664 rs10173848 chr2:28143017 G/T cg27432699 chr2:27873401 GPN1 -0.52 -6.31 -0.33 8.83e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg25173405 chr17:45401733 C17orf57 0.36 5.72 0.3 2.36e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs61931739 1.000 rs12311881 chr12:34036100 A/G cg06521331 chr12:34319734 NA 0.4 6.62 0.34 1.44e-10 Morning vs. evening chronotype; LUSC cis rs11792861 0.781 rs2151426 chr9:111743797 A/C cg05043794 chr9:111880884 C9orf5 -0.37 -7.68 -0.39 1.74e-13 Menarche (age at onset); LUSC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg22800045 chr5:56110881 MAP3K1 0.45 6.53 0.34 2.47e-10 Breast cancer;Breast cancer (early onset); LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg11060661 chr22:24314208 DDT;DDTL 0.5 8.08 0.4 1.17e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg03929089 chr4:120376271 NA -0.82 -11.69 -0.54 1.08e-26 Coronary artery disease; LUSC cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg07828340 chr4:882639 GAK 1.07 11.31 0.53 2.41e-25 Intelligence (multi-trait analysis); LUSC trans rs72674100 1.000 rs10010641 chr4:97966171 C/T cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.03e-17 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg07677032 chr17:61819896 STRADA 0.54 8.95 0.44 2.58e-17 Prudent dietary pattern; LUSC cis rs11190604 1.000 rs11190540 chr10:102202629 A/G cg16342193 chr10:102329863 NA -0.33 -5.98 -0.31 5.69e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10892173 0.782 rs6421566 chr11:117671398 G/A cg21640587 chr11:117668038 DSCAML1 0.36 5.72 0.3 2.36e-8 Myopia; LUSC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg20307385 chr11:47447363 PSMC3 0.45 5.82 0.3 1.37e-8 Subjective well-being; LUSC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg16049864 chr8:95962084 TP53INP1 0.41 7.16 0.36 5.26e-12 Alzheimer's disease (late onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18364837 chr5:148737347 PCYOX1L 0.44 6.71 0.34 8.57e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.58 -8.32 -0.41 2.3e-15 Menarche (age at onset); LUSC cis rs7937682 0.632 rs4441050 chr11:111772506 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.59 0.57 5.09e-30 Primary sclerosing cholangitis; LUSC cis rs34779708 0.649 rs34421369 chr10:35550275 G/C cg03585969 chr10:35415529 CREM 0.53 7.37 0.37 1.32e-12 Inflammatory bowel disease;Crohn's disease; LUSC trans rs12043259 1.000 rs10900427 chr1:204848187 C/G cg23865240 chr7:27134109 HOXA1 -0.57 -6.01 -0.31 4.86e-9 Addiction; LUSC trans rs2587949 0.615 rs1319844 chr3:4229928 T/C cg15139668 chr4:4577005 NA -0.4 -6.06 -0.31 3.62e-9 Periodontitis (DPAL); LUSC cis rs748404 0.697 rs475227 chr15:43546446 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.42 6.04 0.31 4.03e-9 Lung cancer; LUSC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg04865166 chr7:105162814 PUS7 0.51 5.74 0.3 2.17e-8 Bipolar disorder (body mass index interaction); LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.4 -6.69 -0.34 9.5e-11 Prudent dietary pattern; LUSC cis rs2898681 0.581 rs936690 chr4:53691035 A/G cg00338735 chr4:53728038 RASL11B 0.42 5.87 0.31 1.05e-8 Optic nerve measurement (cup area); LUSC cis rs950169 0.922 rs11638445 chr15:85137694 C/A cg17507749 chr15:85114479 UBE2QP1 0.71 8.82 0.43 6.56e-17 Schizophrenia; LUSC trans rs11098499 0.604 rs2389887 chr4:120570644 T/C cg25214090 chr10:38739885 LOC399744 0.5 7.32 0.37 1.88e-12 Corneal astigmatism; LUSC cis rs7561273 0.545 rs13035774 chr2:24358652 C/T cg08063864 chr2:24346004 PFN4;LOC375190 -0.42 -5.82 -0.3 1.37e-8 Quantitative traits; LUSC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.84 -0.39 6.11e-14 Personality dimensions; LUSC trans rs9747201 1.000 rs4506966 chr17:80175421 T/C cg07393940 chr7:158741817 NA 0.51 8.0 0.4 2.07e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14429012 chr9:34458458 C9orf25;DNAI1 0.74 6.1 0.32 2.95e-9 Cognitive performance; LUSC cis rs6840360 0.571 rs12648420 chr4:152543434 G/C cg22705602 chr4:152727874 NA -0.33 -6.63 -0.34 1.36e-10 Intelligence (multi-trait analysis); LUSC cis rs12534701 0.904 rs3817518 chr7:154672809 C/T cg24255201 chr7:154684926 DPP6 0.39 5.85 0.3 1.16e-8 Colorectal cancer (diet interaction); LUSC trans rs11039798 0.623 rs7294273 chr11:48705374 T/C cg03929089 chr4:120376271 NA 0.67 7.39 0.37 1.2e-12 Axial length; LUSC cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg08999081 chr20:33150536 PIGU -0.36 -6.46 -0.33 3.62e-10 Glomerular filtration rate (creatinine); LUSC cis rs9942416 0.660 rs193344 chr5:74977854 T/C cg19683494 chr5:74908142 NA -0.42 -6.6 -0.34 1.58e-10 Age-related disease endophenotypes; LUSC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs11051970 0.879 rs2651362 chr12:32587851 G/C cg24626660 chr12:32551988 NA 0.33 5.66 0.3 3.2e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7474896 0.583 rs7071147 chr10:38003376 T/C cg25427524 chr10:38739819 LOC399744 -0.5 -7.01 -0.36 1.32e-11 Obesity (extreme); LUSC cis rs17270561 0.779 rs17271767 chr6:25886921 C/T cg17691542 chr6:26056736 HIST1H1C 0.83 11.27 0.52 3.55e-25 Iron status biomarkers; LUSC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg00255919 chr5:131827918 IRF1 -0.43 -8.16 -0.41 6.83e-15 Asthma (sex interaction); LUSC cis rs4704187 0.687 rs1903838 chr5:74479999 G/A cg03227963 chr5:74354835 NA 0.29 6.24 0.32 1.32e-9 Response to amphetamines; LUSC trans rs853679 0.607 rs33932084 chr6:28268824 A/G cg01620082 chr3:125678407 NA -0.72 -7.04 -0.36 1.07e-11 Depression; LUSC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4148883 0.675 rs34511427 chr4:100105405 G/T cg12011299 chr4:100065546 ADH4 0.47 7.66 0.39 2.01e-13 Alcohol dependence; LUSC trans rs7170930 0.618 rs8040520 chr15:66556154 A/G cg06396762 chr16:3202609 NA -0.72 -5.98 -0.31 5.75e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2197308 0.765 rs11182434 chr12:37923968 C/A cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg05347473 chr6:146136440 FBXO30 0.5 8.41 0.42 1.17e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7575217 0.884 rs1192787 chr2:101783029 C/T cg23907051 chr2:101730305 TBC1D8 -0.27 -6.56 -0.34 2.06e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs9325144 0.555 rs6582576 chr12:38701230 C/T cg13010199 chr12:38710504 ALG10B -0.5 -7.55 -0.38 4.23e-13 Morning vs. evening chronotype; LUSC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.03 0.4 1.69e-14 Melanoma; LUSC cis rs1348850 0.958 rs4528793 chr2:178464271 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 5.96 0.31 6.38e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.41 -7.64 -0.39 2.29e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs2717559 0.542 rs2717590 chr8:143900712 A/G cg07661805 chr8:143867942 LY6D -0.26 -5.87 -0.31 1.07e-8 Urinary tract infection frequency; LUSC cis rs12545109 0.571 rs4237014 chr8:57284479 C/A cg09654669 chr8:57350985 NA -0.44 -5.87 -0.31 1.04e-8 Obesity-related traits; LUSC cis rs2985684 0.948 rs2883437 chr14:50031666 A/G cg04989706 chr14:50066350 PPIL5 -0.47 -6.09 -0.32 3.12e-9 Carotid intima media thickness; LUSC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg25019033 chr10:957182 NA -0.52 -5.98 -0.31 5.87e-9 Eosinophil percentage of granulocytes; LUSC trans rs1325195 0.520 rs3122378 chr1:179234045 A/C cg11624085 chr17:8464688 MYH10 0.43 6.73 0.35 7.6e-11 IgE grass sensitization; LUSC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.06 -0.48 5.7e-21 Allergic disease (asthma, hay fever or eczema); LUSC trans rs7824557 0.767 rs3808513 chr8:11157460 G/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.72 -0.39 1.35e-13 Retinal vascular caliber; LUSC cis rs2219968 1.000 rs36124379 chr8:78963505 T/C cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9341808 0.714 rs9448911 chr6:80913859 A/G cg08355045 chr6:80787529 NA 0.48 8.36 0.42 1.7e-15 Sitting height ratio; LUSC trans rs62055045 0.528 rs62056195 chr16:71549485 A/G cg23742233 chr15:96890880 NA -0.48 -6.35 -0.33 7.08e-10 Schizophrenia; LUSC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg22963979 chr7:1858916 MAD1L1 -0.58 -9.15 -0.45 5.77e-18 Bipolar disorder and schizophrenia; LUSC cis rs4332037 0.826 rs4721188 chr7:1953615 G/A cg23422044 chr7:1970798 MAD1L1 0.59 6.96 0.36 1.81e-11 Bipolar disorder; LUSC cis rs10871290 0.551 rs3863435 chr16:74465396 C/G cg01733217 chr16:74700730 RFWD3 -0.6 -9.15 -0.45 5.88e-18 Breast cancer; LUSC cis rs7707921 0.881 rs324914 chr5:81389950 C/T cg15871215 chr5:81402204 ATG10 0.44 6.66 0.34 1.14e-10 Breast cancer; LUSC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg25019033 chr10:957182 NA -0.52 -6.55 -0.34 2.19e-10 Eosinophil percentage of granulocytes; LUSC cis rs8050260 0.500 rs4783650 chr16:68558528 T/C cg02508848 chr16:68573721 ZFP90 0.45 5.71 0.3 2.55e-8 Plateletcrit; LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 13.92 0.61 4.85e-35 Alzheimer's disease; LUSC cis rs61935443 0.720 rs10859784 chr12:95288926 G/A cg21533806 chr12:95267307 NA 0.52 6.43 0.33 4.5e-10 Schizophrenia; LUSC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs7824557 0.564 rs2043508 chr8:11227406 G/A cg15556689 chr8:8085844 FLJ10661 -0.57 -8.58 -0.42 3.51e-16 Retinal vascular caliber; LUSC trans rs28735056 0.620 rs12456484 chr18:77677315 C/G cg05926928 chr17:57297772 GDPD1 0.44 6.23 0.32 1.36e-9 Schizophrenia; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.93 0.48 1.53e-20 Bipolar disorder; LUSC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg11279151 chr3:101281821 RG9MTD1 -0.4 -5.76 -0.3 1.92e-8 Colonoscopy-negative controls vs population controls; LUSC trans rs10435719 0.647 rs10092605 chr8:11787395 T/G cg15556689 chr8:8085844 FLJ10661 0.57 8.69 0.43 1.7e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4948102 0.599 rs2230197 chr7:56126360 T/C cg17215666 chr7:56131930 SUMF2 0.45 5.98 0.31 5.75e-9 Plasma homocysteine levels (post-methionine load test); LUSC cis rs728616 0.558 rs12414691 chr10:82156982 A/T cg05935833 chr10:81318306 SFTPA2 -0.44 -5.8 -0.3 1.57e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg16423285 chr20:60520624 NA -0.46 -5.86 -0.31 1.12e-8 Body mass index; LUSC cis rs7719624 0.692 rs2237065 chr5:135367220 C/T cg12897067 chr5:135418308 NA -0.43 -6.31 -0.33 9.09e-10 Response to cytidine analogues (gemcitabine); LUSC cis rs2635047 0.811 rs17785603 chr18:44769534 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 6.13 0.32 2.5e-9 Educational attainment; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 13.96 0.61 3.17e-35 Platelet count; LUSC trans rs8073060 0.586 rs11080356 chr17:33895309 T/C cg19694781 chr19:47549865 TMEM160 1.13 18.42 0.71 8.74e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs3862030 0.810 rs5870 chr10:104239100 A/G cg22532475 chr10:104410764 TRIM8 0.24 5.65 0.3 3.45e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7605827 0.930 rs11684001 chr2:15513120 C/T cg19274914 chr2:15703543 NA 0.46 8.94 0.44 2.66e-17 Educational attainment (years of education); LUSC trans rs11722228 0.521 rs62288520 chr4:10099674 G/A cg26043149 chr18:55253948 FECH 0.98 14.93 0.63 5.84e-39 Gout;Urate levels;Serum uric acid levels; LUSC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.48 0.53 5.96e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg26380479 chr7:97908229 NA -0.27 -5.84 -0.3 1.23e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg00033643 chr7:134001901 SLC35B4 -0.41 -6.4 -0.33 5.14e-10 Mean platelet volume; LUSC trans rs877282 0.628 rs11253435 chr10:824169 T/C cg22713356 chr15:30763199 NA 0.79 10.17 0.49 2.4e-21 Uric acid levels; LUSC cis rs12681287 0.711 rs28506490 chr8:87246118 T/C cg27223183 chr8:87520930 FAM82B -0.46 -5.8 -0.3 1.54e-8 Caudate activity during reward; LUSC cis rs911119 0.955 rs1011226 chr20:23605833 G/T cg16589663 chr20:23618590 CST3 -0.58 -7.02 -0.36 1.23e-11 Chronic kidney disease; LUSC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg14416269 chr4:6271139 WFS1 -0.54 -10.55 -0.5 1.22e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs67981189 0.593 rs221925 chr14:71579629 T/G cg15816911 chr14:71606274 NA -0.34 -5.94 -0.31 6.99e-9 Schizophrenia; LUSC cis rs713587 0.626 rs62140636 chr2:25233811 T/C cg15423357 chr2:25149977 NA -0.36 -7.15 -0.36 5.41e-12 Body mass index in non-asthmatics; LUSC trans rs11918654 0.840 rs7614778 chr3:5202793 T/C cg24725692 chr4:140478735 SETD7 0.3 5.98 0.31 5.63e-9 Disc degeneration (lumbar); LUSC cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -1.19 -27.11 -0.83 2.32e-86 Chronic sinus infection; LUSC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg26408565 chr15:76604113 ETFA -0.47 -7.42 -0.38 9.75e-13 Blood metabolite levels; LUSC cis rs7089973 0.604 rs7897937 chr10:116591318 A/G cg25233709 chr10:116636983 FAM160B1 0.37 6.59 0.34 1.69e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg26335602 chr6:28129616 ZNF389 0.4 5.64 0.3 3.57e-8 Parkinson's disease; LUSC cis rs56399783 0.901 rs17132624 chr7:2778496 G/A cg14895029 chr7:2775587 GNA12 0.52 5.72 0.3 2.43e-8 Childhood ear infection; LUSC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg06022373 chr22:39101656 GTPBP1 0.84 13.27 0.59 1.44e-32 Menopause (age at onset); LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg00431813 chr7:1051703 C7orf50 -0.44 -7.02 -0.36 1.21e-11 Longevity;Endometriosis; LUSC cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg13010199 chr12:38710504 ALG10B 0.64 9.79 0.47 4.49e-20 Bladder cancer; LUSC trans rs11039798 0.858 rs7121333 chr11:48332138 C/T cg03929089 chr4:120376271 NA 0.66 6.22 0.32 1.47e-9 Axial length; LUSC cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.51 7.68 0.39 1.81e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs4714291 0.802 rs2984430 chr6:39983741 A/G cg02267698 chr19:7991119 CTXN1 -0.53 -7.85 -0.39 5.68e-14 Strep throat; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg25703541 chr22:24373054 LOC391322 0.82 10.45 0.5 2.64e-22 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg14784868 chr12:69753453 YEATS4 0.89 15.67 0.65 7.27e-42 Cerebrospinal fluid biomarker levels; LUSC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg11301795 chr4:187892539 NA 0.81 15.62 0.65 1.12e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg10956904 chr3:52443970 BAP1;PHF7 0.4 6.76 0.35 6.13e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg13047869 chr3:10149882 C3orf24 0.6 8.5 0.42 6.41e-16 Alzheimer's disease; LUSC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg11214544 chr1:2391121 NA -0.59 -9.85 -0.47 3e-20 Non-obstructive azoospermia; LUSC cis rs789859 0.611 rs1077729 chr3:194418126 A/G cg21106136 chr3:194405973 FAM43A 0.4 6.57 0.34 1.98e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs4319547 0.656 rs7397299 chr12:122821649 G/T cg05707623 chr12:122985044 ZCCHC8 -0.58 -7.33 -0.37 1.75e-12 Body mass index; LUSC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg09034736 chr1:150693464 HORMAD1 0.42 5.81 0.3 1.49e-8 Melanoma; LUSC cis rs1371867 0.817 rs1788185 chr8:101335529 T/C cg06636551 chr8:101224915 SPAG1 -0.44 -7.91 -0.4 3.71e-14 Atrioventricular conduction; LUSC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg05855489 chr10:104503620 C10orf26 -0.61 -7.76 -0.39 1.07e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg05340658 chr4:99064831 C4orf37 0.68 11.43 0.53 8.93e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs2303282 0.716 rs2587870 chr16:56410831 C/T cg00500540 chr16:56394104 NA -0.44 -7.6 -0.38 3.04e-13 Breast cancer; LUSC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg04317338 chr11:64019027 PLCB3 0.66 7.5 0.38 5.84e-13 Mean platelet volume; LUSC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg06634786 chr22:41940651 POLR3H 0.49 5.72 0.3 2.34e-8 Vitiligo; LUSC trans rs4948088 1.000 rs2329565 chr7:51017653 T/C cg26816907 chr1:197890812 LHX9 0.56 6.22 0.32 1.47e-9 Type 1 diabetes; LUSC cis rs2236918 0.643 rs1776139 chr1:242027363 T/G cg17736920 chr1:242011382 EXO1 0.39 6.16 0.32 2.13e-9 Menopause (age at onset); LUSC cis rs9467773 0.566 rs66972160 chr6:26359306 T/C cg09904177 chr6:26538194 HMGN4 -0.52 -8.16 -0.41 6.82e-15 Intelligence (multi-trait analysis); LUSC cis rs1997103 1.000 rs11238364 chr7:55407632 G/T cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs11098499 1.000 rs1011054 chr4:120202387 A/G cg09307838 chr4:120376055 NA -0.65 -9.31 -0.45 1.78e-18 Corneal astigmatism; LUSC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.78 10.04 0.48 6.51e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11098499 0.780 rs10013652 chr4:120292256 A/G cg09307838 chr4:120376055 NA 0.68 10.16 0.49 2.61e-21 Corneal astigmatism; LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg13560548 chr3:10150139 C3orf24 0.54 7.74 0.39 1.17e-13 Alzheimer's disease; LUSC cis rs3781458 0.803 rs11245321 chr10:126323279 C/T cg20435097 chr10:126320824 FAM53B 0.23 6.02 0.31 4.64e-9 Male-pattern baldness; LUSC cis rs738321 0.757 rs2235345 chr22:38518177 C/T cg25457927 chr22:38595422 NA -0.37 -7.05 -0.36 1.04e-11 Breast cancer; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.47 -6.31 -0.33 8.84e-10 Renal function-related traits (BUN); LUSC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg02079420 chr8:82753780 SNX16 0.42 7.15 0.36 5.48e-12 Diastolic blood pressure; LUSC cis rs35146811 0.735 rs858505 chr7:99819577 G/A cg13334819 chr7:99746414 C7orf59 0.5 6.68 0.34 9.99e-11 Coronary artery disease; LUSC cis rs7819412 0.811 rs2409691 chr8:10943276 C/T cg21775007 chr8:11205619 TDH -0.41 -5.9 -0.31 9.14e-9 Triglycerides; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.08 16.84 0.68 1.64e-46 Gut microbiome composition (summer); LUSC cis rs6500602 0.702 rs2058812 chr16:4524443 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.52 6.96 0.36 1.81e-11 Schizophrenia; LUSC cis rs10203711 1.000 rs4663940 chr2:239570382 C/T cg14580085 chr2:239553406 NA 0.43 7.32 0.37 1.85e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.67e-9 Monocyte count; LUSC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg25456477 chr12:86230367 RASSF9 0.41 7.31 0.37 2.04e-12 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18104674 chr18:60190218 ZCCHC2 -0.42 -6.23 -0.32 1.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg15704280 chr7:45808275 SEPT13 1.03 17.71 0.7 6.06e-50 Coronary artery disease; LUSC cis rs6700896 0.966 rs4655729 chr1:66082471 A/G cg04111102 chr1:66153794 NA 0.31 6.92 0.35 2.3e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7149337 0.805 rs7146561 chr14:51608889 C/G cg23942311 chr14:51606299 NA 0.49 11.44 0.53 8.76e-26 Cancer; LUSC cis rs3101457 0.515 rs4658629 chr1:244516754 G/T cg09033006 chr1:244517177 C1orf100 -0.42 -6.18 -0.32 1.92e-9 Smoking behavior; LUSC cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg11266682 chr4:10021025 SLC2A9 0.55 10.04 0.48 6.83e-21 Bone mineral density; LUSC cis rs2120019 0.567 rs68036747 chr15:75203200 A/C cg09165964 chr15:75287851 SCAMP5 -0.96 -11.82 -0.54 3.63e-27 Blood trace element (Zn levels); LUSC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg18876405 chr7:65276391 NA 0.55 8.56 0.42 4.15e-16 Aortic root size; LUSC trans rs11098499 0.863 rs7669520 chr4:120515278 T/C cg25214090 chr10:38739885 LOC399744 0.53 7.95 0.4 2.95e-14 Corneal astigmatism; LUSC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg13175981 chr1:150552382 MCL1 0.47 6.7 0.34 8.66e-11 Tonsillectomy; LUSC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg19622623 chr12:86230825 RASSF9 -0.42 -5.82 -0.3 1.36e-8 Major depressive disorder; LUSC cis rs79349575 0.783 rs62075838 chr17:46996432 C/T cg22482690 chr17:47019901 SNF8 0.4 7.47 0.38 7.15e-13 Type 2 diabetes; LUSC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg11644478 chr21:40555479 PSMG1 0.93 17.46 0.69 5.9e-49 Cognitive function; LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.2 0.66 5.64e-44 Platelet count; LUSC cis rs4930103 0.619 rs739905 chr11:1980360 G/C cg26856596 chr11:1961893 NA 0.34 6.36 0.33 6.61e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.45 -0.38 7.98e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs644799 0.648 rs1255182 chr11:95472391 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.6 9.35 0.46 1.28e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs8032315 0.965 rs35346340 chr15:91427872 G/C cg04510874 chr15:91427884 FES 0.31 6.01 0.31 4.77e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs71636778 0.509 rs71636795 chr1:27241025 A/G cg12203394 chr1:27248618 NUDC 0.53 5.65 0.3 3.47e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs5758659 0.729 rs134866 chr22:42650663 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.3 -6.24 -0.32 1.34e-9 Cognitive function; LUSC cis rs7267979 1.000 rs6083809 chr20:25329309 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.35 -0.33 7.19e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg11189052 chr15:85197271 WDR73 -0.66 -10.13 -0.48 3.38e-21 P wave terminal force; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05827267 chr22:42084837 NHP2L1 -0.43 -6.45 -0.33 3.92e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg15147215 chr3:52552868 STAB1 -0.3 -6.02 -0.31 4.62e-9 Electroencephalogram traits; LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg22535103 chr8:58192502 C8orf71 -0.67 -7.57 -0.38 3.68e-13 Developmental language disorder (linguistic errors); LUSC cis rs11122272 0.735 rs2790873 chr1:231539685 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.21 -0.49 1.82e-21 Hemoglobin concentration; LUSC cis rs941408 1.000 rs1640273 chr19:2803227 C/T cg06609049 chr19:2785107 THOP1 0.67 10.68 0.5 4.07e-23 Total cholesterol levels; LUSC trans rs3749237 0.964 rs1799845 chr3:49847623 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.47 6.53 0.34 2.44e-10 Resting heart rate; LUSC cis rs12973672 0.812 rs2280744 chr19:35755386 G/A cg12095397 chr19:35769544 USF2 0.41 6.14 0.32 2.31e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs977987 0.762 rs1364079 chr16:75393131 C/A cg03315344 chr16:75512273 CHST6 0.53 10.28 0.49 1.03e-21 Dupuytren's disease; LUSC cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg11266682 chr4:10021025 SLC2A9 -0.56 -8.55 -0.42 4.35e-16 Bone mineral density; LUSC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg21724239 chr8:58056113 NA 0.58 7.26 0.37 2.82e-12 Developmental language disorder (linguistic errors); LUSC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg03563238 chr19:33554763 RHPN2 0.34 5.85 0.3 1.16e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7107174 1.000 rs4945270 chr11:78068216 A/G cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs9283706 0.623 rs1159201 chr5:66311339 C/T cg11590213 chr5:66331682 MAST4 -0.4 -5.93 -0.31 7.6e-9 Coronary artery disease; LUSC cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg05729581 chr11:3078854 CARS -0.55 -8.48 -0.42 7.43e-16 Longevity; LUSC cis rs9811920 0.809 rs7649349 chr3:99725629 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -7.1 -0.36 7.36e-12 Axial length; LUSC cis rs7588746 0.621 rs2060122 chr2:201153177 A/G cg23649088 chr2:200775458 C2orf69 -0.42 -5.91 -0.31 8.36e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg23625390 chr15:77176239 SCAPER 0.46 7.06 0.36 9.57e-12 Blood metabolite levels; LUSC cis rs9457247 0.508 rs2285147 chr6:167505548 G/A cg07741184 chr6:167504864 NA 0.39 6.92 0.35 2.34e-11 Crohn's disease; LUSC cis rs7909074 0.798 rs914699 chr10:45377066 A/C cg04218760 chr10:45406644 TMEM72 -0.29 -6.99 -0.36 1.49e-11 Mean corpuscular volume; LUSC cis rs617219 0.853 rs57587638 chr5:78513167 C/T cg24856658 chr5:78533917 JMY -0.3 -6.02 -0.31 4.54e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs6736093 0.796 rs34128716 chr2:112812856 C/G cg12686935 chr2:112915763 FBLN7 -0.4 -6.35 -0.33 7.04e-10 Coronary artery disease; LUSC cis rs9611519 0.780 rs2235850 chr22:41657626 C/T cg03806693 chr22:41940476 POLR3H -0.59 -8.66 -0.43 2e-16 Neuroticism; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg18758796 chr5:131593413 PDLIM4 0.51 8.61 0.43 2.93e-16 Acylcarnitine levels; LUSC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg16520312 chr17:43971471 MAPT;LOC100128977 -0.37 -6.22 -0.32 1.46e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs308403 0.509 rs7690133 chr4:123673809 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.94 16.09 0.66 1.63e-43 Blood protein levels; LUSC cis rs1994135 0.669 rs10844629 chr12:33697096 T/A cg06521331 chr12:34319734 NA -0.39 -5.74 -0.3 2.14e-8 Resting heart rate; LUSC cis rs459571 0.959 rs392134 chr9:136909008 G/A cg13789015 chr9:136890014 NCRNA00094 0.72 13.06 0.58 8.81e-32 Platelet distribution width; LUSC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg10664184 chr19:17420304 DDA1 0.47 6.13 0.32 2.46e-9 Systemic lupus erythematosus; LUSC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.64 7.91 0.4 3.71e-14 Lung function (FEV1/FVC); LUSC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg20503657 chr10:835505 NA 1.23 16.69 0.67 6.75e-46 Eosinophil percentage of granulocytes; LUSC cis rs1595825 0.891 rs16826791 chr2:198895133 C/G cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg23758822 chr17:41437982 NA 1.05 21.01 0.75 4.75e-63 Menopause (age at onset); LUSC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg00599273 chr12:58146742 CDK4 0.31 5.81 0.3 1.48e-8 Multiple sclerosis; LUSC cis rs1577917 0.958 rs67024565 chr6:86553997 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.79 -0.35 5.27e-11 Response to antipsychotic treatment; LUSC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.48 0.53 5.99e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg11861562 chr11:117069780 TAGLN -0.45 -8.14 -0.41 8.15e-15 Blood protein levels; LUSC cis rs9902453 0.935 rs9905950 chr17:28431198 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.61 0.5 7.45e-23 Coffee consumption (cups per day); LUSC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.65e-16 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13246654 chr4:114682613 CAMK2D -0.42 -6.01 -0.31 4.75e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15388598 chr13:95953941 ABCC4 -0.42 -6.06 -0.31 3.6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4969178 0.930 rs12601079 chr17:76400329 G/A cg05887092 chr17:76393375 PGS1 0.51 9.14 0.45 6.32e-18 HDL cholesterol levels; LUSC trans rs9329221 0.905 rs13254263 chr8:10255181 A/G cg08975724 chr8:8085496 FLJ10661 -0.5 -7.24 -0.37 3.14e-12 Neuroticism; LUSC cis rs897984 0.683 rs8046001 chr16:30833321 C/T cg00531865 chr16:30841666 NA -0.34 -6.14 -0.32 2.36e-9 Dementia with Lewy bodies; LUSC cis rs10489202 0.608 rs10918826 chr1:168075316 C/T cg24449463 chr1:168025552 DCAF6 -0.64 -9.82 -0.47 3.58e-20 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21890592 chr7:5013639 RNF216L -0.41 -5.96 -0.31 6.48e-9 Electrocardiographic conduction measures; LUSC cis rs9611565 0.625 rs2076199 chr22:41903743 G/T cg03806693 chr22:41940476 POLR3H -0.85 -12.2 -0.56 1.48e-28 Vitiligo; LUSC cis rs1448094 0.967 rs7961782 chr12:86326461 T/C cg00310523 chr12:86230176 RASSF9 0.4 7.33 0.37 1.8e-12 Major depressive disorder; LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg14092988 chr3:52407081 DNAH1 0.33 6.41 0.33 4.93e-10 Bipolar disorder; LUSC cis rs4343996 0.967 rs4316064 chr7:3358580 A/G cg21248987 chr7:3385318 SDK1 0.34 5.84 0.3 1.27e-8 Motion sickness; LUSC cis rs6700559 0.654 rs12061556 chr1:200650239 G/C cg07804481 chr1:200639085 DDX59 0.41 5.77 0.3 1.85e-8 Coronary artery disease; LUSC cis rs72781680 0.848 rs55725028 chr2:23966447 A/G cg08917208 chr2:24149416 ATAD2B 0.98 9.95 0.48 1.34e-20 Lymphocyte counts; LUSC trans rs7395662 0.591 rs4882012 chr11:48560597 T/A cg03929089 chr4:120376271 NA -0.44 -6.15 -0.32 2.24e-9 HDL cholesterol; LUSC cis rs7681440 0.583 rs2583966 chr4:90741519 G/A cg06632027 chr4:90757378 SNCA -0.36 -5.7 -0.3 2.57e-8 Dementia with Lewy bodies; LUSC cis rs9467773 0.595 rs2172007 chr6:26639777 A/C cg09904177 chr6:26538194 HMGN4 0.65 11.47 0.53 6.41e-26 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg01982873 chr5:490308 SLC9A3 0.35 6.46 0.33 3.81e-10 Cystic fibrosis severity; LUSC trans rs9650657 0.513 rs4841459 chr8:10782442 A/C cg06636001 chr8:8085503 FLJ10661 -0.53 -7.59 -0.38 3.31e-13 Neuroticism; LUSC cis rs2137920 0.945 rs2466751 chr10:50239936 A/G cg27141751 chr10:50231850 C10orf72 0.39 5.79 0.3 1.62e-8 Migraine with aura; LUSC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg18190219 chr22:46762943 CELSR1 -0.45 -6.16 -0.32 2.11e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs34779708 0.931 rs4934710 chr10:35350416 T/C cg03585969 chr10:35415529 CREM 0.58 8.43 0.42 1.02e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7193541 0.684 rs9931225 chr16:74699293 T/C cg01733217 chr16:74700730 RFWD3 1.0 22.71 0.78 1.04e-69 Multiple myeloma; LUSC cis rs3960554 0.808 rs2286829 chr7:75677739 G/A cg17325771 chr7:75508891 RHBDD2 -0.41 -5.84 -0.3 1.27e-8 Eotaxin levels; LUSC cis rs6577655 0.517 rs4909293 chr8:135587888 G/A cg17885191 chr8:135476712 NA 0.6 7.78 0.39 9.33e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg07606381 chr6:8435919 SLC35B3 0.71 11.99 0.55 8.83e-28 Motion sickness; LUSC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg13072238 chr3:49761600 GMPPB 0.68 8.35 0.42 1.87e-15 Menarche (age at onset); LUSC cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.44e-23 Bladder cancer; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg22535103 chr8:58192502 C8orf71 -0.79 -8.22 -0.41 4.44e-15 Developmental language disorder (linguistic errors); LUSC cis rs354225 0.544 rs13403284 chr2:54805749 A/G cg26097391 chr2:54893211 SPTBN1 0.46 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs1712517 0.771 rs11191664 chr10:105118476 C/T cg05636881 chr10:105038444 INA 0.4 6.74 0.35 7.11e-11 Migraine; LUSC cis rs9309473 0.898 rs6546851 chr2:73833283 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.51 -0.34 2.77e-10 Metabolite levels; LUSC cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.57 0.65 1.85e-41 Bladder cancer; LUSC cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg18252515 chr7:66147081 NA -0.57 -7.9 -0.4 4.08e-14 Corneal structure; LUSC cis rs62408225 0.963 rs45553631 chr6:90981657 C/T cg06866423 chr6:90926672 BACH2 0.41 5.92 0.31 7.99e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9399401 0.626 rs6906468 chr6:142769386 A/G cg04461802 chr6:142623433 GPR126 0.45 6.15 0.32 2.27e-9 Chronic obstructive pulmonary disease; LUSC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs4400599 1.000 rs4400599 chr1:154127100 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.35 -5.71 -0.3 2.52e-8 Platelet distribution width; LUSC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg19812747 chr11:111475976 SIK2 -0.51 -7.4 -0.38 1.1e-12 Primary sclerosing cholangitis; LUSC cis rs17270561 0.609 rs9393659 chr6:25731358 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.6 0.38 3.1e-13 Iron status biomarkers; LUSC cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg08975724 chr8:8085496 FLJ10661 0.46 7.16 0.36 5.15e-12 Mood instability; LUSC cis rs6489882 0.703 rs10850097 chr12:113361117 C/T cg20102336 chr12:113376681 OAS3 -0.42 -6.07 -0.32 3.43e-9 Chronic lymphocytic leukemia; LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg16362232 chr11:430036 ANO9 0.66 8.29 0.41 2.74e-15 Body mass index; LUSC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg24562669 chr7:97807699 LMTK2 0.34 6.06 0.31 3.66e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7927771 0.524 rs7129797 chr11:47667167 G/C cg20307385 chr11:47447363 PSMC3 0.44 6.3 0.33 9.23e-10 Subjective well-being; LUSC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg06740227 chr12:86229804 RASSF9 0.44 7.12 0.36 6.75e-12 Major depressive disorder; LUSC cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg11057378 chr10:81107060 PPIF 0.37 6.21 0.32 1.57e-9 Height; LUSC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg14159672 chr1:205819179 PM20D1 0.85 15.3 0.64 2.01e-40 Menarche (age at onset); LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg01802117 chr1:53393560 SCP2 0.4 6.66 0.34 1.11e-10 Monocyte count; LUSC cis rs5769707 0.837 rs1573726 chr22:50032872 G/A cg10356904 chr22:49881777 NA -0.3 -6.71 -0.34 8.17e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.13 -0.36 6.32e-12 Menopause (age at onset); LUSC trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg20587970 chr11:113659929 NA -1.36 -19.2 -0.72 6.89e-56 Hip circumference adjusted for BMI; LUSC cis rs2227564 0.672 rs10824042 chr10:75645628 C/T cg23231163 chr10:75533350 FUT11 -0.43 -5.94 -0.31 7.3e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1568889 1.000 rs12800354 chr11:28047723 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 8.94 0.44 2.63e-17 Bipolar disorder; LUSC cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 8.21 0.41 4.89e-15 Body mass index (adult); LUSC cis rs6977660 0.714 rs12334267 chr7:19810265 A/G cg05791153 chr7:19748676 TWISTNB 0.66 7.04 0.36 1.11e-11 Thyroid stimulating hormone; LUSC trans rs11935423 0.778 rs6841211 chr4:100501690 T/C cg02164153 chr5:172068145 NEURL1B -0.47 -6.05 -0.31 3.97e-9 Gut microbiome composition (summer); LUSC cis rs7107174 1.000 rs7939646 chr11:78111613 C/T cg02023728 chr11:77925099 USP35 -0.44 -6.52 -0.34 2.61e-10 Testicular germ cell tumor; LUSC cis rs1107366 0.505 rs12489314 chr3:125976864 A/G cg01346077 chr3:125931526 NA 0.3 5.67 0.3 3.02e-8 Metabolite levels; LUSC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.87 -0.35 3.2e-11 Lung cancer; LUSC trans rs731565 1.000 rs731565 chr7:147406262 C/T cg20906291 chr6:10382103 NA -0.54 -6.13 -0.32 2.55e-9 Diabetic kidney disease; LUSC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg18876405 chr7:65276391 NA -0.7 -12.66 -0.57 2.88e-30 Aortic root size; LUSC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg02117656 chr17:79614917 TSPAN10 0.31 5.75 0.3 1.98e-8 Eye color traits; LUSC cis rs4906332 1.000 rs17680085 chr14:103953154 T/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.16 -0.36 5.08e-12 Coronary artery disease; LUSC cis rs6964587 1.000 rs2282974 chr7:91761617 G/A cg01689657 chr7:91764605 CYP51A1 0.34 6.12 0.32 2.69e-9 Breast cancer; LUSC cis rs7267979 0.586 rs6083776 chr20:25186116 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.63 0.57 3.63e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7592578 0.679 rs4287794 chr2:191327147 T/C cg11845111 chr2:191398756 TMEM194B -0.83 -11.09 -0.52 1.53e-24 Diastolic blood pressure; LUSC cis rs11098499 0.754 rs878376 chr4:120237702 G/A cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs1865760 0.566 rs3752420 chr6:26027135 G/A cg16482183 chr6:26056742 HIST1H1C 0.54 7.92 0.4 3.62e-14 Height; LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg04025307 chr7:1156635 C7orf50 0.47 7.4 0.38 1.15e-12 Longevity;Endometriosis; LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs6690583 0.623 rs74761855 chr1:85432947 A/C cg11262906 chr1:85462892 MCOLN2 0.7 6.73 0.35 7.37e-11 Serum sulfate level; LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg08280861 chr8:58055591 NA 0.54 6.52 0.34 2.65e-10 Developmental language disorder (linguistic errors); LUSC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg08048268 chr3:133502702 NA 0.52 10.68 0.5 4.11e-23 Iron status biomarkers; LUSC trans rs6461049 0.646 rs3778970 chr7:2143208 C/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.19 0.32 1.76e-9 Schizophrenia; LUSC cis rs11866815 0.901 rs758033 chr16:397044 G/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.39 6.15 0.32 2.23e-9 Body mass index; LUSC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.86 0.39 5.51e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11098499 0.779 rs10857066 chr4:120286596 C/T cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.95 0.36 1.95e-11 Intelligence (multi-trait analysis); LUSC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg22875332 chr1:76189707 ACADM 0.75 10.1 0.48 4.06e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg25554036 chr4:6271136 WFS1 0.56 10.67 0.5 4.58e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg25460059 chr11:9595544 WEE1 0.49 6.12 0.32 2.6e-9 Cognitive function;Information processing speed; LUSC cis rs1008375 0.900 rs13101742 chr4:17701297 G/A cg16339924 chr4:17578868 LAP3 -0.53 -7.46 -0.38 7.36e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3772130 0.564 rs35178434 chr3:121595936 G/A cg20356878 chr3:121714668 ILDR1 0.6 9.74 0.47 6.85e-20 Cognitive performance; LUSC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg27170947 chr2:26402098 FAM59B -0.62 -9.21 -0.45 3.74e-18 Gut microbiome composition (summer); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08693705 chr5:179719171 MAPK9 0.46 6.39 0.33 5.64e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 7.3 0.37 2.08e-12 Bipolar disorder; LUSC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg20790798 chr5:1857306 NA -0.5 -8.73 -0.43 1.26e-16 Cardiovascular disease risk factors; LUSC cis rs12421382 0.639 rs12791519 chr11:109486754 A/G cg27471124 chr11:109292789 C11orf87 0.38 6.65 0.34 1.18e-10 Schizophrenia; LUSC trans rs61931739 0.817 rs188588 chr12:34215277 G/A cg24313572 chr1:56050060 NA -0.3 -6.3 -0.33 9.43e-10 Morning vs. evening chronotype; LUSC cis rs4969178 0.896 rs1976704 chr17:76401318 C/T cg05887092 chr17:76393375 PGS1 0.51 8.94 0.44 2.62e-17 HDL cholesterol levels; LUSC cis rs7267979 1.000 rs6115182 chr20:25410259 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg27535305 chr1:53392650 SCP2 -0.43 -8.63 -0.43 2.49e-16 Monocyte count; LUSC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.47 -0.8 1.71e-76 Height; LUSC cis rs4073582 0.595 rs10896104 chr11:66001869 C/T cg16950941 chr11:66035639 RAB1B 0.52 7.7 0.39 1.5700000000000001e-13 Gout; LUSC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg02423579 chr7:2872169 GNA12 -0.47 -7.06 -0.36 9.55e-12 Height; LUSC cis rs10904908 0.733 rs359288 chr10:17330180 A/G cg01003015 chr10:17271136 VIM -0.39 -5.79 -0.3 1.62e-8 Total cholesterol levels;Cholesterol, total; LUSC trans rs60843830 0.661 rs55987018 chr2:106655 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.51 8.02 0.4 1.79e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs800082 0.516 rs9813164 chr3:144227590 A/G cg24215973 chr2:240111563 HDAC4 0.45 6.76 0.35 6.1e-11 Smoking behavior; LUSC cis rs2932538 0.961 rs3013441 chr1:113192605 C/T cg22162597 chr1:113214053 CAPZA1 -0.68 -9.27 -0.45 2.3e-18 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7945718 0.935 rs1609442 chr11:12795418 T/A cg25843174 chr11:12811716 TEAD1 0.33 7.31 0.37 2.03e-12 Educational attainment (years of education); LUSC cis rs2749592 0.725 rs9417245 chr10:37826322 C/T cg25427524 chr10:38739819 LOC399744 0.47 7.3 0.37 2.11e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9650657 0.584 rs28613656 chr8:10695419 G/A cg27411982 chr8:10470053 RP1L1 -0.38 -6.25 -0.32 1.28e-9 Neuroticism; LUSC cis rs7267979 1.000 rs422844 chr20:25445591 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.64 7.85 0.39 5.88e-14 Lung function (FEV1/FVC); LUSC cis rs4566357 0.615 rs10198214 chr2:227913314 A/C cg11843606 chr2:227700838 RHBDD1 -0.54 -8.29 -0.41 2.72e-15 Coronary artery disease; LUSC cis rs7633770 0.965 rs6804112 chr3:46686248 C/T cg11219411 chr3:46661640 NA 0.38 7.76 0.39 1.06e-13 Coronary artery disease; LUSC cis rs4737010 0.501 rs34342524 chr8:41633857 G/A cg17182837 chr8:41585554 ANK1 0.38 6.54 0.34 2.36e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs2070488 0.804 rs13092473 chr3:38458958 A/G cg24069376 chr3:38537580 EXOG 0.38 7.22 0.37 3.52e-12 Electrocardiographic conduction measures; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg22963979 chr7:1858916 MAD1L1 -0.64 -10.19 -0.49 2.04e-21 Bipolar disorder and schizophrenia; LUSC cis rs9303401 0.659 rs12946397 chr17:56769979 C/T cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs6500602 0.527 rs13338333 chr16:4443250 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 6.39 0.33 5.64e-10 Schizophrenia; LUSC cis rs35264875 1.000 rs72928652 chr11:68851547 G/A cg02660097 chr11:68866761 NA 0.43 6.1 0.32 2.9e-9 Blond vs. brown hair color; LUSC cis rs7705502 1.000 rs72812840 chr5:173374655 A/G cg18693985 chr5:173351052 CPEB4 -0.37 -5.86 -0.31 1.11e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs1005277 0.505 rs1208689 chr10:38097775 C/G cg17830980 chr10:43048298 ZNF37B -0.41 -6.35 -0.33 7.03e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs3020736 0.500 rs764481 chr22:42518426 G/A cg04733989 chr22:42467013 NAGA -0.61 -9.44 -0.46 6.61e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs870825 0.616 rs12498890 chr4:185636096 C/G cg04058563 chr4:185651563 MLF1IP -0.87 -13.36 -0.59 6.37e-33 Blood protein levels; LUSC cis rs933688 0.532 rs997737 chr5:90567031 C/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.49 -6.11 -0.32 2.82e-9 Smoking behavior; LUSC cis rs6696846 0.765 rs11240360 chr1:205083865 T/C cg21545522 chr1:205238299 TMCC2 0.46 8.53 0.42 5.15e-16 Red blood cell count; LUSC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg00933542 chr6:150070202 PCMT1 0.34 6.99 0.36 1.52e-11 Lung cancer; LUSC cis rs11098499 0.909 rs10002083 chr4:120311152 C/T cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs9467711 0.606 rs4634439 chr6:26598004 C/T cg12826209 chr6:26865740 GUSBL1 -0.69 -6.31 -0.33 9.11e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg11189052 chr15:85197271 WDR73 0.46 5.66 0.3 3.26e-8 Schizophrenia; LUSC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg16447950 chr5:562315 NA -0.58 -7.11 -0.36 7.26e-12 Obesity-related traits; LUSC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg23630131 chr7:65973040 NA 0.21 5.81 0.3 1.42e-8 Aortic root size; LUSC cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg24642439 chr20:33292090 TP53INP2 0.49 7.34 0.37 1.62e-12 Glomerular filtration rate (creatinine); LUSC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19346786 chr7:2764209 NA -0.45 -7.77 -0.39 9.87e-14 Height; LUSC cis rs9814567 0.806 rs6799543 chr3:134216139 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.65 -0.6 5.22e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg20887711 chr4:1340912 KIAA1530 0.69 10.4 0.49 4.04e-22 Longevity; LUSC trans rs11039798 1.000 rs8188963 chr11:48685693 C/A cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC cis rs72781680 0.706 rs72794290 chr2:23896106 A/T cg20701182 chr2:24300061 SF3B14 0.77 7.42 0.38 9.57e-13 Lymphocyte counts; LUSC cis rs8114671 0.935 rs633198 chr20:33778434 T/C cg07148914 chr20:33460835 GGT7 -0.45 -6.64 -0.34 1.28e-10 Height; LUSC cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg08048268 chr3:133502702 NA -0.35 -6.52 -0.34 2.57e-10 Alcohol consumption (transferrin glycosylation); LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.16 -0.36 5.13e-12 Bipolar disorder; LUSC trans rs1005277 0.563 rs2505216 chr10:38482830 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.15 -0.45 5.6e-18 Extrinsic epigenetic age acceleration; LUSC cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg26384229 chr12:38710491 ALG10B 0.89 15.05 0.64 2.03e-39 Drug-induced liver injury (flucloxacillin); LUSC trans rs12310956 0.531 rs10772110 chr12:33841755 A/G cg26384229 chr12:38710491 ALG10B 0.48 7.08 0.36 8.44e-12 Morning vs. evening chronotype; LUSC cis rs7402982 0.934 rs8027457 chr15:99204101 A/G cg03437748 chr15:99193247 IGF1R 0.52 8.24 0.41 4.06e-15 Birth weight; LUSC cis rs11247915 0.583 rs66569416 chr1:26659737 C/G cg04990556 chr1:26633338 UBXN11 -0.49 -6.75 -0.35 6.4e-11 Obesity-related traits; LUSC cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.88 0.31 9.93e-9 Rheumatoid arthritis; LUSC cis rs6964587 0.839 rs6949700 chr7:91467435 A/G cg17063962 chr7:91808500 NA 0.54 8.3 0.41 2.62e-15 Breast cancer; LUSC trans rs853679 0.825 rs8180562 chr6:28141460 G/A cg01620082 chr3:125678407 NA -0.59 -6.55 -0.34 2.21e-10 Depression; LUSC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg05025164 chr4:1340916 KIAA1530 0.55 8.62 0.43 2.72e-16 Longevity; LUSC cis rs2559856 1.000 rs2695285 chr12:102089043 G/A cg12924262 chr12:102091054 CHPT1 0.43 6.12 0.32 2.57e-9 Blood protein levels; LUSC cis rs7474896 0.583 rs10764144 chr10:37975732 G/C cg25427524 chr10:38739819 LOC399744 -0.49 -6.61 -0.34 1.53e-10 Obesity (extreme); LUSC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg14895029 chr7:2775587 GNA12 -0.43 -6.54 -0.34 2.26e-10 Height; LUSC trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg13615516 chr5:77269221 NA 0.39 6.52 0.34 2.54e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg14689365 chr7:158441557 NCAPG2 0.53 7.54 0.38 4.35e-13 Height; LUSC cis rs11098499 0.863 rs9884402 chr4:120489982 A/G cg09307838 chr4:120376055 NA 0.74 10.76 0.51 2.3e-23 Corneal astigmatism; LUSC cis rs11039100 0.607 rs35527801 chr11:5782540 G/A cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1018836 0.892 rs10103198 chr8:91579436 A/T cg16814680 chr8:91681699 NA -0.65 -10.17 -0.49 2.36e-21 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg07097265 chr17:17727093 SREBF1 0.35 6.21 0.32 1.61e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg27266027 chr21:40555129 PSMG1 -0.39 -5.68 -0.3 2.94e-8 Cognitive function; LUSC cis rs3857536 0.740 rs7773577 chr6:66892124 G/A cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs55910451 0.549 rs72772358 chr10:5817627 T/A cg11519256 chr10:5708881 ASB13 -0.5 -6.33 -0.33 7.84e-10 Breast cancer; LUSC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg10018233 chr7:150070692 REPIN1 0.4 6.69 0.34 9.18e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg03517284 chr6:25882590 NA -0.43 -7.39 -0.38 1.16e-12 Intelligence (multi-trait analysis); LUSC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg05623727 chr3:50126028 RBM5 0.32 6.04 0.31 4.04e-9 Intelligence (multi-trait analysis); LUSC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg11764359 chr7:65958608 NA -0.7 -10.63 -0.5 6.55e-23 Aortic root size; LUSC cis rs1577917 0.883 rs9450348 chr6:86598036 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -6.36 -0.33 6.51e-10 Response to antipsychotic treatment; LUSC cis rs17125944 0.505 rs2295827 chr14:53174981 C/T cg13660082 chr14:53194042 PSMC6 -0.77 -7.01 -0.36 1.3e-11 Alzheimer's disease (late onset); LUSC cis rs13006833 0.668 rs291449 chr2:191177467 A/G cg21644426 chr2:191273491 MFSD6 -0.42 -5.94 -0.31 7.09e-9 Urinary metabolites; LUSC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg12463550 chr7:65579703 CRCP -0.51 -7.54 -0.38 4.53e-13 Aortic root size; LUSC cis rs981844 0.816 rs62325147 chr4:154727568 G/A cg14289246 chr4:154710475 SFRP2 0.48 6.3 0.33 9.33e-10 Response to statins (LDL cholesterol change); LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05902063 chr12:96794315 CDK17 -0.45 -6.48 -0.33 3.37e-10 Bipolar disorder and schizophrenia; LUSC cis rs11031096 0.655 rs12293706 chr11:4211581 C/G cg18678763 chr11:4115507 RRM1 -0.41 -5.71 -0.3 2.5e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs13253111 0.624 rs1979330 chr8:28096051 T/A cg26534493 chr8:28060551 NA 0.39 7.01 0.36 1.35e-11 Childhood body mass index; LUSC cis rs11155671 0.530 rs7758020 chr6:150208111 T/C cg09699651 chr6:150184138 LRP11 0.45 7.15 0.36 5.64e-12 Testicular germ cell tumor; LUSC trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs6951245 0.872 rs77569514 chr7:1085508 G/A cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs61931739 0.500 rs11053282 chr12:34561151 T/C cg06521331 chr12:34319734 NA -0.42 -6.48 -0.33 3.32e-10 Morning vs. evening chronotype; LUSC cis rs2692947 0.770 rs58730124 chr2:96413338 T/C cg23100626 chr2:96804247 ASTL 0.29 6.89 0.35 2.78e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06553422 chr19:15560234 WIZ;MIR1470 0.76 6.65 0.34 1.23e-10 Cognitive performance; LUSC trans rs1864729 0.901 rs2451114 chr8:98273762 G/A cg08679828 chr8:102218111 ZNF706 -0.74 -6.83 -0.35 4.03e-11 Estradiol plasma levels (breast cancer); LUSC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg17376030 chr22:41985996 PMM1 -0.46 -5.84 -0.3 1.26e-8 Vitiligo; LUSC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg19592336 chr6:28129416 ZNF389 0.48 6.27 0.32 1.11e-9 Depression; LUSC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg13770153 chr20:60521292 NA -0.53 -7.1 -0.36 7.73e-12 Body mass index; LUSC cis rs4409675 0.576 rs12070659 chr1:28227175 G/A cg23691781 chr1:28212827 C1orf38 0.31 7.48 0.38 6.53e-13 Corneal astigmatism; LUSC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -8.31 -0.41 2.37e-15 Alzheimer's disease; LUSC cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg00012203 chr2:219082015 ARPC2 -0.77 -13.07 -0.58 8.24e-32 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg08742575 chr21:47604166 C21orf56 0.45 6.93 0.35 2.19e-11 Testicular germ cell tumor; LUSC cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg08213375 chr14:104286397 PPP1R13B 0.52 10.24 0.49 1.38e-21 Schizophrenia; LUSC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC trans rs629535 0.767 rs72654070 chr8:70079369 G/A cg21567404 chr3:27674614 NA -0.97 -15.59 -0.65 1.43e-41 Dupuytren's disease; LUSC trans rs2288327 0.557 rs60488846 chr2:179357842 C/T cg14011486 chr1:26737247 LIN28 0.77 9.66 0.47 1.22e-19 Atrial fibrillation; LUSC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.41 -5.87 -0.31 1.05e-8 Personality dimensions; LUSC cis rs422249 0.512 rs174562 chr11:61585144 A/G cg19610905 chr11:61596333 FADS2 -0.54 -8.09 -0.4 1.13e-14 Trans fatty acid levels; LUSC cis rs7937682 0.924 rs499750 chr11:111513645 T/G cg09085632 chr11:111637200 PPP2R1B -1.1 -17.58 -0.69 1.84e-49 Primary sclerosing cholangitis; LUSC cis rs9463078 0.683 rs12215252 chr6:44736265 C/T cg25276700 chr6:44698697 NA 0.32 6.35 0.33 7.1e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs6690583 0.697 rs4907126 chr1:85523453 C/T cg22153463 chr1:85462885 MCOLN2 0.61 7.98 0.4 2.42e-14 Serum sulfate level; LUSC cis rs138918 0.772 rs138937 chr22:43568060 C/G cg08909806 chr22:43548696 TSPO 0.35 5.98 0.31 5.81e-9 Monocyte count; LUSC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg16423285 chr20:60520624 NA -0.46 -5.84 -0.3 1.23e-8 Body mass index; LUSC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg13607699 chr17:42295918 UBTF 0.5 8.03 0.4 1.66e-14 Total body bone mineral density; LUSC cis rs7106204 0.609 rs34376029 chr11:24291233 C/T ch.11.24196551F chr11:24239977 NA 0.69 5.74 0.3 2.14e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2692947 0.683 rs62153700 chr2:96581338 C/T cg23100626 chr2:96804247 ASTL 0.3 7.0 0.36 1.44e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4343996 0.870 rs4722712 chr7:3389147 C/T cg21248987 chr7:3385318 SDK1 -0.42 -7.24 -0.37 3.15e-12 Motion sickness; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10916625 chr20:48330123 B4GALT5 -0.4 -5.94 -0.31 6.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.59 -7.85 -0.39 5.74e-14 Chronic sinus infection; LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs4664304 0.900 rs17231993 chr2:160741415 C/T cg23995753 chr2:160760732 LY75 -0.33 -6.09 -0.32 3.07e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4805272 0.582 rs11083652 chr19:29231569 G/C cg14983838 chr19:29218262 NA -0.42 -6.27 -0.32 1.09e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs7843479 1.000 rs11775444 chr8:21813018 A/G cg09788866 chr2:128051348 ERCC3 -0.39 -5.95 -0.31 6.67e-9 Mean corpuscular volume; LUSC cis rs1801251 1.000 rs36007169 chr2:233621834 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.74 0.35 7.17e-11 Coronary artery disease; LUSC cis rs2109514 0.902 rs7810505 chr7:116111078 G/T cg12739419 chr7:116140593 CAV2 -0.27 -5.92 -0.31 7.84e-9 Prevalent atrial fibrillation; LUSC cis rs2404602 0.647 rs34103231 chr15:76912690 A/G cg23625390 chr15:77176239 SCAPER -0.65 -9.66 -0.47 1.25e-19 Blood metabolite levels; LUSC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg00933542 chr6:150070202 PCMT1 0.32 6.58 0.34 1.86e-10 Lung cancer; LUSC cis rs7100689 0.646 rs4601708 chr10:82119583 G/T cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC trans rs6982636 1.000 rs2980855 chr8:126477476 T/C cg13325919 chr3:181432053 SOX2;SOX2OT -0.35 -6.68 -0.34 1e-10 Lipid metabolism phenotypes; LUSC cis rs3099143 1.000 rs1114717 chr15:77086078 A/G cg21673338 chr15:77095150 SCAPER 0.77 7.82 0.39 7.04e-14 Recalcitrant atopic dermatitis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05628496 chr17:17991167 DRG2 0.4 5.95 0.31 6.81e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17125944 0.686 rs78623109 chr14:53383077 G/T cg00686598 chr14:53173677 PSMC6 0.84 7.58 0.38 3.44e-13 Alzheimer's disease (late onset); LUSC cis rs2180341 0.538 rs3756993 chr6:127651551 A/C cg24812749 chr6:127587940 RNF146 0.63 9.49 0.46 4.62e-19 Breast cancer; LUSC cis rs2233152 0.610 rs10405596 chr19:41314720 C/T cg21869046 chr19:41225005 ITPKC 0.45 6.18 0.32 1.85e-9 Kawasaki disease; LUSC cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg26384229 chr12:38710491 ALG10B 0.63 10.03 0.48 7.4e-21 Morning vs. evening chronotype; LUSC cis rs4073582 0.595 rs10896104 chr11:66001869 C/T cg14036092 chr11:66035641 RAB1B 0.42 6.11 0.32 2.85e-9 Gout; LUSC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg16262614 chr3:133464971 TF 0.43 7.51 0.38 5.41e-13 Iron status biomarkers (transferrin levels); LUSC cis rs7903847 0.642 rs4635018 chr10:99137839 C/G cg20016023 chr10:99160130 RRP12 0.34 8.0 0.4 2.08e-14 Granulocyte percentage of myeloid white cells; LUSC trans rs3733585 0.631 rs4697707 chr4:10119787 G/T cg26043149 chr18:55253948 FECH -0.54 -7.99 -0.4 2.25e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg04871131 chr7:94954202 PON1 -0.37 -6.02 -0.31 4.59e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.22 0.41 4.58e-15 Axial length; LUSC cis rs701145 0.586 rs181443 chr3:153959028 G/T cg10247383 chr3:153839028 SGEF -0.5 -6.11 -0.32 2.79e-9 Coronary artery disease; LUSC cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs72781680 1.000 rs72798417 chr2:24188656 C/T cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs4148883 0.737 rs13148577 chr4:100060836 G/A cg12011299 chr4:100065546 ADH4 0.5 8.4 0.42 1.29e-15 Alcohol dependence; LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg08280861 chr8:58055591 NA 0.59 7.24 0.37 3.21e-12 Developmental language disorder (linguistic errors); LUSC trans rs2243480 1.000 rs6460260 chr7:65215455 T/C cg10756647 chr7:56101905 PSPH -0.83 -8.16 -0.41 7.1e-15 Diabetic kidney disease; LUSC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 9.29 0.45 2.08e-18 Mean platelet volume; LUSC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg24733560 chr20:60626293 TAF4 0.41 6.73 0.35 7.47e-11 Body mass index; LUSC cis rs12286929 0.617 rs11607801 chr11:115077367 A/C cg04055981 chr11:115044050 NA 0.44 7.88 0.4 4.71e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11958404 0.929 rs60700182 chr5:157438376 A/G cg05962755 chr5:157440814 NA 0.53 6.3 0.33 9.34e-10 IgG glycosylation; LUSC cis rs4852324 0.541 rs7568898 chr2:74271577 C/T cg05890377 chr2:74357713 NA 0.46 5.71 0.3 2.48e-8 Systemic lupus erythematosus; LUSC cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg05347473 chr6:146136440 FBXO30 0.53 8.91 0.44 3.27e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11644478 chr21:40555479 PSMG1 0.93 18.36 0.71 1.51e-52 Cognitive function; LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg01125463 chr6:42946178 PEX6 -0.35 -5.81 -0.3 1.42e-8 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23120805 chr2:43453872 LOC100129726;ZFP36L2 -0.39 -5.96 -0.31 6.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg11905131 chr22:24372483 LOC391322 -0.6 -10.06 -0.48 5.7e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2625529 0.590 rs713048 chr15:72543084 G/A cg16672083 chr15:72433130 SENP8 -0.5 -7.65 -0.39 2.15e-13 Red blood cell count; LUSC cis rs7072216 0.691 rs7910973 chr10:100166732 G/A cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg01363383 chr10:111967257 MXI1 0.41 5.99 0.31 5.43e-9 Triglycerides; LUSC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg23172400 chr8:95962367 TP53INP1 -0.43 -8.82 -0.43 6.61e-17 Type 2 diabetes; LUSC cis rs208520 0.690 rs207118 chr6:66788948 T/A cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs9768139 0.935 rs62480865 chr7:158122307 A/C cg25566285 chr7:158114605 PTPRN2 -0.32 -5.73 -0.3 2.29e-8 Calcium levels; LUSC cis rs838147 0.507 rs692854 chr19:49209464 C/A cg21064579 chr19:49206444 FUT2 0.45 8.48 0.42 7.34e-16 Dietary macronutrient intake; LUSC cis rs1957429 0.901 rs1467570 chr14:65347858 A/G cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs500891 0.525 rs4706991 chr6:84109088 C/T cg08257003 chr6:84140564 ME1 0.35 8.38 0.42 1.48e-15 Platelet-derived growth factor BB levels; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg14789911 chr21:47582049 C21orf56 0.36 5.64 0.3 3.57e-8 Testicular germ cell tumor; LUSC cis rs7617773 0.817 rs9830016 chr3:48282494 A/G cg11946769 chr3:48343235 NME6 0.79 13.37 0.59 5.73e-33 Coronary artery disease; LUSC cis rs7572733 0.534 rs58374969 chr2:198764363 C/T cg00792783 chr2:198669748 PLCL1 0.45 5.87 0.31 1.04e-8 Dermatomyositis; LUSC cis rs3008870 0.920 rs975452 chr1:67480190 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.31 0.64 1.87e-40 Lymphocyte percentage of white cells; LUSC cis rs4363385 0.720 rs9325996 chr1:152965347 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.66 -0.39 2.08e-13 Inflammatory skin disease; LUSC cis rs11098499 0.913 rs56122576 chr4:120129336 A/G cg09307838 chr4:120376055 NA 0.68 9.65 0.47 1.32e-19 Corneal astigmatism; LUSC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg09877947 chr5:131593287 PDLIM4 0.39 6.39 0.33 5.68e-10 Blood metabolite levels; LUSC cis rs12216125 0.537 rs12207059 chr6:25922385 C/T cg17042849 chr6:26104293 HIST1H4C -0.57 -6.64 -0.34 1.27e-10 Iron status biomarkers; LUSC cis rs2742417 1.000 rs2673065 chr3:45771222 C/T cg18779283 chr3:45636154 LIMD1 -0.33 -5.65 -0.3 3.52e-8 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs2229238 0.911 rs73020234 chr1:154482767 C/A cg25273160 chr11:56955011 LRRC55 0.31 5.96 0.31 6.37e-9 Coronary heart disease; LUSC cis rs2041895 0.509 rs2072559 chr12:107307287 T/G cg13944111 chr12:107296891 NA 0.37 6.37 0.33 6.16e-10 Glaucoma (low intraocular pressure); LUSC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.41 -0.42 1.21e-15 Lung cancer; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg09033563 chr22:24373618 LOC391322 -0.47 -6.58 -0.34 1.84e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1568889 1.000 rs16917735 chr11:28119980 A/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.61 -8.73 -0.43 1.2e-16 Bipolar disorder; LUSC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg22029157 chr1:209979665 IRF6 -0.71 -8.64 -0.43 2.28e-16 Cleft lip with or without cleft palate; LUSC cis rs677665 0.537 rs12121476 chr1:9335327 C/G cg25755851 chr1:9335794 NA 0.8 12.42 0.56 2.15e-29 Eosinophil percentage of white cells; LUSC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.71 -0.3 2.47e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs13315871 1.000 rs9850717 chr3:58351875 C/T cg20936604 chr3:58311152 NA -0.59 -5.91 -0.31 8.65e-9 Cholesterol, total; LUSC cis rs1865760 0.929 rs1436307 chr6:25939723 C/T cg17691542 chr6:26056736 HIST1H1C 0.49 7.19 0.37 4.26e-12 Height; LUSC trans rs330071 0.500 rs17662123 chr8:9246837 G/A cg15556689 chr8:8085844 FLJ10661 0.49 7.52 0.38 5.25e-13 Acne (severe); LUSC cis rs9486719 0.843 rs3860229 chr6:97036559 T/C cg06623918 chr6:96969491 KIAA0776 -0.83 -12.1 -0.55 3.35e-28 Migraine;Coronary artery disease; LUSC cis rs1865721 1.000 rs17283692 chr18:73193911 T/C cg26385618 chr18:73139727 C18orf62 -0.48 -8.1 -0.41 1.04e-14 Intelligence; LUSC cis rs13385 0.769 rs4913072 chr5:139608353 T/C cg26211634 chr5:139558579 C5orf32 0.46 6.91 0.35 2.53e-11 Atrial fibrillation; LUSC trans rs804280 0.542 rs34117651 chr8:11791617 G/C cg15556689 chr8:8085844 FLJ10661 0.57 8.48 0.42 7.31e-16 Myopia (pathological); LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg22143856 chr6:28129313 ZNF389 0.42 5.78 0.3 1.73e-8 Parkinson's disease; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -8.12 -0.41 9.16e-15 Lymphocyte counts; LUSC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC cis rs7923609 0.870 rs10822156 chr10:65080727 T/C cg01631684 chr10:65280961 REEP3 -0.41 -6.43 -0.33 4.51e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10383028 chr17:48638097 CACNA1G -0.41 -6.16 -0.32 2.04e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.22 0.45 3.34e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311676 0.656 rs56384862 chr3:58395863 A/G cg26110898 chr3:58419937 PDHB 0.4 6.46 0.33 3.65e-10 Systemic lupus erythematosus; LUSC cis rs4363385 0.747 rs2879489 chr1:152970465 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.79 -0.39 8.81e-14 Inflammatory skin disease; LUSC cis rs11690935 0.571 rs1008151 chr2:172912098 G/A cg13550731 chr2:172543902 DYNC1I2 0.53 8.17 0.41 6.61e-15 Schizophrenia; LUSC cis rs7178572 0.568 rs12912050 chr15:77689423 C/T cg22256960 chr15:77711686 NA -0.48 -7.59 -0.38 3.26e-13 Type 2 diabetes; LUSC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg24531977 chr5:56204891 C5orf35 -0.98 -14.46 -0.62 3.73e-37 Initial pursuit acceleration; LUSC cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg24692254 chr21:30365293 RNF160 -0.84 -15.34 -0.64 1.37e-40 Dental caries; LUSC cis rs1670533 1.000 rs6812586 chr4:1069851 A/G cg27284194 chr4:1044797 NA 0.58 8.9 0.44 3.65e-17 Recombination rate (females); LUSC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg08499158 chr17:42289980 UBTF -0.52 -8.58 -0.42 3.63e-16 Total body bone mineral density; LUSC cis rs2235649 0.833 rs9927047 chr16:1851927 A/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.42 -6.02 -0.31 4.48e-9 Blood metabolite levels; LUSC cis rs5758511 0.524 rs738257 chr22:42569298 C/A cg00645731 chr22:42541494 CYP2D7P1 0.59 10.05 0.48 6.04e-21 Birth weight; LUSC cis rs4363385 0.747 rs1415960 chr1:152973571 G/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.88 -0.4 4.72e-14 Inflammatory skin disease; LUSC cis rs644799 0.562 rs671320 chr11:95578780 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.68 10.27 0.49 1.1e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC cis rs4285028 0.948 rs71329247 chr3:121681523 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.73 -9.47 -0.46 5.35e-19 Multiple sclerosis; LUSC cis rs9303401 0.573 rs34717648 chr17:56886624 T/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.35 0.59 7.02e-33 Cognitive test performance; LUSC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.27 0.45 2.39e-18 Monocyte percentage of white cells; LUSC trans rs61931739 0.534 rs2667447 chr12:34133468 C/A cg26384229 chr12:38710491 ALG10B 0.68 10.62 0.5 7e-23 Morning vs. evening chronotype; LUSC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -8.43 -0.42 1.05e-15 Axial length; LUSC cis rs4423214 1.000 rs11233746 chr11:71171440 A/G cg05163923 chr11:71159392 DHCR7 0.76 11.45 0.53 8.11e-26 Vitamin D levels; LUSC cis rs1570884 0.516 rs9316462 chr13:50176321 A/G cg08779649 chr13:50194554 NA 0.41 6.92 0.35 2.27e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.76 -0.51 2.14e-23 Alzheimer's disease; LUSC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.52e-8 Extrinsic epigenetic age acceleration; LUSC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.29 -0.33 9.9e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg05585544 chr11:47624801 NA -0.43 -7.51 -0.38 5.31e-13 Subjective well-being; LUSC cis rs9341808 0.529 rs4706840 chr6:81057769 T/A cg08355045 chr6:80787529 NA 0.47 7.83 0.39 6.65e-14 Sitting height ratio; LUSC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.0 -0.36 1.44e-11 Alzheimer's disease (late onset); LUSC cis rs453301 0.686 rs11785819 chr8:8870378 T/G cg15556689 chr8:8085844 FLJ10661 -0.61 -9.55 -0.46 2.96e-19 Joint mobility (Beighton score); LUSC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg19592336 chr6:28129416 ZNF389 0.52 7.22 0.37 3.42e-12 Parkinson's disease; LUSC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg03806693 chr22:41940476 POLR3H -1.06 -15.36 -0.64 1.17e-40 Vitiligo; LUSC cis rs9462027 0.628 rs6905393 chr6:34776626 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC trans rs800082 0.593 rs4349542 chr3:144176717 A/G cg24215973 chr2:240111563 HDAC4 0.4 5.97 0.31 6.2e-9 Smoking behavior; LUSC cis rs7923609 1.000 rs4399232 chr10:64999490 C/T cg01631684 chr10:65280961 REEP3 -0.41 -6.46 -0.33 3.7e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg00684032 chr4:1343700 KIAA1530 0.34 5.8 0.3 1.55e-8 Obesity-related traits; LUSC trans rs7980799 0.682 rs10844612 chr12:33603676 T/C cg26384229 chr12:38710491 ALG10B -0.6 -8.94 -0.44 2.73e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs17685 0.712 rs28506984 chr7:75763484 A/G cg19862616 chr7:65841803 NCRNA00174 1.14 19.75 0.73 4.69e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -12.22 -0.56 1.23e-28 Chronic sinus infection; LUSC cis rs981844 0.712 rs1350189 chr4:154744951 A/T cg14289246 chr4:154710475 SFRP2 -0.44 -6.11 -0.32 2.84e-9 Response to statins (LDL cholesterol change); LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg20295408 chr7:1910781 MAD1L1 -0.41 -5.92 -0.31 8.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs4077468 1.000 rs9662221 chr1:205915745 G/T cg14893161 chr1:205819251 PM20D1 -0.42 -6.04 -0.31 4.15e-9 Cystic fibrosis-related diabetes; LUSC cis rs1729407 0.625 rs2727789 chr11:116696887 G/T cg08985259 chr11:116699649 APOC3 -0.24 -5.7 -0.3 2.7e-8 Apolipoprotein A-IV levels; LUSC cis rs12908161 0.920 rs35758837 chr15:85311382 C/T cg17173187 chr15:85201210 NMB 0.5 9.39 0.46 9.83e-19 Schizophrenia; LUSC cis rs12476592 0.602 rs1255 chr2:63825934 T/C cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg06008330 chr7:65541103 ASL -0.37 -5.69 -0.3 2.79e-8 Aortic root size; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9527 0.590 rs10883834 chr10:104881402 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC trans rs61931739 0.500 rs7971957 chr12:34477558 C/T cg26384229 chr12:38710491 ALG10B 0.8 13.67 0.6 4.37e-34 Morning vs. evening chronotype; LUSC cis rs734999 0.588 rs6668149 chr1:2558308 A/C cg18854424 chr1:2615690 NA -0.5 -10.01 -0.48 8.46e-21 Ulcerative colitis; LUSC trans rs12210905 0.920 rs9368500 chr6:27290981 A/C cg11837749 chr1:55047332 ACOT11 0.66 6.3 0.33 9.13e-10 Hip circumference adjusted for BMI; LUSC cis rs3126085 0.877 rs1552996 chr1:152171104 C/A cg26876637 chr1:152193138 HRNR 0.47 6.82 0.35 4.29e-11 Atopic dermatitis; LUSC cis rs35851103 0.600 rs4841662 chr8:11843758 A/G cg21775007 chr8:11205619 TDH -0.5 -7.39 -0.37 1.2e-12 Neuroticism; LUSC cis rs2463822 1.000 rs2513074 chr11:62100880 A/C cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2074585 0.517 rs11637971 chr15:91079863 A/C cg22089800 chr15:90895588 ZNF774 -0.57 -8.08 -0.4 1.17e-14 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs57221529 0.766 rs72703075 chr5:592819 C/T cg16447950 chr5:562315 NA -0.61 -7.13 -0.36 6.23e-12 Lung disease severity in cystic fibrosis; LUSC cis rs73206853 0.841 rs60219027 chr12:110759843 T/G cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9399137 0.507 rs11758774 chr6:135383789 T/G cg22676075 chr6:135203613 NA 0.56 8.8 0.43 7.39e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs10203711 1.000 rs4994753 chr2:239567253 T/C cg14580085 chr2:239553406 NA 0.41 6.99 0.36 1.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2625529 0.652 rs8036307 chr15:72175120 A/G cg16672083 chr15:72433130 SENP8 0.48 7.91 0.4 3.87e-14 Red blood cell count; LUSC cis rs11105298 0.891 rs6538190 chr12:89885942 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.04e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg26513180 chr16:89883248 FANCA 0.91 17.61 0.69 1.5e-49 Vitiligo; LUSC cis rs877282 0.733 rs7092976 chr10:756358 G/A cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC trans rs10838798 0.504 rs10838852 chr11:48286256 C/T cg15704280 chr7:45808275 SEPT13 -0.44 -6.16 -0.32 2.08e-9 Height; LUSC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg05729581 chr11:3078854 CARS 0.5 7.96 0.4 2.69e-14 Longevity; LUSC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg12667521 chr19:29218732 NA 0.52 6.95 0.36 1.96e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs34421088 0.560 rs1478898 chr8:11395079 G/A cg15556689 chr8:8085844 FLJ10661 -0.61 -9.7 -0.47 9.35e-20 Neuroticism; LUSC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg16744531 chr19:17905626 B3GNT3 0.43 6.36 0.33 6.73e-10 Tumor biomarkers; LUSC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg10755058 chr3:40428713 ENTPD3 0.35 5.74 0.3 2.17e-8 Renal cell carcinoma; LUSC cis rs2760061 0.583 rs708113 chr1:228192753 T/A cg01973587 chr1:228161476 NA -0.36 -6.02 -0.31 4.61e-9 Diastolic blood pressure; LUSC cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg22709100 chr7:91322751 NA 0.39 5.78 0.3 1.67e-8 Breast cancer; LUSC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg22834771 chr12:69754056 YEATS4 -0.49 -7.39 -0.37 1.22e-12 Blood protein levels; LUSC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg17376030 chr22:41985996 PMM1 -0.46 -5.79 -0.3 1.65e-8 Vitiligo; LUSC cis rs11098499 0.909 rs17046118 chr4:120387496 T/G cg24375607 chr4:120327624 NA 0.79 11.67 0.54 1.27e-26 Corneal astigmatism; LUSC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.61 9.23 0.45 3.28e-18 Menarche (age at onset); LUSC cis rs2635047 0.875 rs2635040 chr18:44640972 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 7.54 0.38 4.36e-13 Educational attainment; LUSC cis rs709400 0.567 rs11624343 chr14:103859156 T/A cg24130564 chr14:104152367 KLC1 -0.41 -5.73 -0.3 2.21e-8 Body mass index; LUSC cis rs10751667 0.961 rs6597951 chr11:991530 C/T cg01483505 chr11:975446 AP2A2 0.41 5.7 0.3 2.58e-8 Alzheimer's disease (late onset); LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg11060661 chr22:24314208 DDT;DDTL 0.48 7.82 0.39 6.95e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg03517284 chr6:25882590 NA -0.53 -8.73 -0.43 1.27e-16 Intelligence (multi-trait analysis); LUSC cis rs4776059 1.000 rs4776059 chr15:52886962 C/T cg25063058 chr15:52860530 ARPP19 0.46 6.29 0.33 1.01e-9 Schizophrenia; LUSC cis rs1775715 0.870 rs10827003 chr10:32266216 A/G cg26784012 chr10:32216390 ARHGAP12 0.41 6.71 0.34 8.4e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7267979 0.966 rs2227892 chr20:25264814 T/C cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.56e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7923609 1.000 rs12355784 chr10:65121565 G/T cg01631684 chr10:65280961 REEP3 -0.4 -6.27 -0.32 1.11e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9788682 1.000 rs2036534 chr15:78826948 T/C cg18825076 chr15:78729989 IREB2 0.47 6.21 0.32 1.57e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg27661571 chr11:113659931 NA 0.63 6.03 0.31 4.37e-9 Hip circumference adjusted for BMI; LUSC cis rs9807989 0.801 rs72823663 chr2:102968738 G/C cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC trans rs6600671 1.000 rs10903159 chr1:121181997 G/T cg00646200 chr1:148855367 NA 0.45 7.16 0.36 5.21e-12 Hip geometry; LUSC cis rs17095355 0.818 rs12571549 chr10:111770013 G/A cg00817464 chr10:111662876 XPNPEP1 -0.6 -6.93 -0.35 2.19e-11 Biliary atresia; LUSC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg26958806 chr6:27640298 NA 0.67 5.88 0.31 1.01e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg12826209 chr6:26865740 GUSBL1 0.73 9.34 0.45 1.45e-18 Intelligence (multi-trait analysis); LUSC cis rs9398803 0.865 rs2184967 chr6:126773487 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.9e-9 Male-pattern baldness; LUSC cis rs4950928 0.712 rs7518666 chr1:203163590 C/T cg17014757 chr1:203156097 CHI3L1 -0.43 -7.63 -0.39 2.46e-13 YKL-40 levels; LUSC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg13319975 chr6:146136371 FBXO30 0.51 7.69 0.39 1.66e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9921192 1.000 rs2892165 chr16:4324293 A/T cg00021532 chr16:4324280 TFAP4 0.8 14.63 0.62 8.48e-38 Prostate-specific antigen levels; LUSC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg18404041 chr3:52824283 ITIH1 0.5 9.53 0.46 3.47e-19 Bipolar disorder; LUSC cis rs925550 0.932 rs7678116 chr4:123571118 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.56 5.94 0.31 7.29e-9 Primary biliary cholangitis; LUSC cis rs11098499 0.866 rs9991221 chr4:120292107 G/C cg24375607 chr4:120327624 NA 0.69 10.58 0.5 9.19e-23 Corneal astigmatism; LUSC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.47 -9.29 -0.45 2e-18 Monocyte percentage of white cells; LUSC cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg08330031 chr10:104623503 C10orf32 0.32 5.82 0.3 1.36e-8 Arsenic metabolism; LUSC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.88e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs11122272 0.735 rs2790897 chr1:231491712 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.23 -0.49 1.46e-21 Hemoglobin concentration; LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.754 rs7672778 chr4:120248585 A/G cg09307838 chr4:120376055 NA 0.7 10.56 0.5 1.1e-22 Corneal astigmatism; LUSC cis rs34779708 0.931 rs12773169 chr10:35366462 G/C cg04310649 chr10:35416472 CREM -0.41 -6.47 -0.33 3.55e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4642101 0.640 rs3901666 chr3:12824363 G/T cg05775895 chr3:12838266 CAND2 -0.52 -8.53 -0.42 5.31e-16 QRS complex (12-leadsum); LUSC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg04865166 chr7:105162814 PUS7 0.54 6.05 0.31 3.95e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg03452623 chr4:187889614 NA -0.93 -19.58 -0.73 2.18e-57 Lobe attachment (rater-scored or self-reported); LUSC cis rs9914988 0.778 rs9907192 chr17:27122426 C/G cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs13092825 1.000 rs6808951 chr3:113274334 A/T cg18753928 chr3:113234510 CCDC52 -0.38 -5.65 -0.3 3.45e-8 Dental caries; LUSC trans rs61931739 0.817 rs10743842 chr12:34306859 C/T cg24313572 chr1:56050060 NA -0.31 -6.45 -0.33 4.02e-10 Morning vs. evening chronotype; LUSC cis rs7567389 0.704 rs4662714 chr2:127995213 A/G cg09760422 chr2:128146352 NA -0.31 -6.52 -0.34 2.66e-10 Self-rated health; LUSC cis rs59698941 0.943 rs67437142 chr5:132306722 T/C cg14825688 chr5:132208181 LEAP2 -0.54 -5.72 -0.3 2.39e-8 Apolipoprotein A-IV levels; LUSC cis rs7188861 0.768 rs441349 chr16:11371759 C/T cg00044050 chr16:11439710 C16orf75 0.55 6.05 0.31 3.79e-9 HDL cholesterol; LUSC cis rs4654899 0.627 rs637990 chr1:21047616 A/G cg01072550 chr1:21505969 NA 0.4 6.06 0.31 3.64e-9 Superior frontal gyrus grey matter volume; LUSC cis rs250677 0.917 rs36066 chr5:148419771 A/G cg23229984 chr5:148520753 ABLIM3 0.37 5.69 0.3 2.83e-8 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14122358 chr17:79829466 ARHGDIA -0.43 -6.37 -0.33 6.43e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17270561 0.636 rs7754814 chr6:25745243 A/T cg16482183 chr6:26056742 HIST1H1C 0.64 9.14 0.45 6.03e-18 Iron status biomarkers; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.11 0.32 2.79e-9 Schizophrenia; LUSC cis rs11971779 0.941 rs6954453 chr7:139031794 C/T cg07862535 chr7:139043722 LUC7L2 0.73 8.2 0.41 5.39e-15 Diisocyanate-induced asthma; LUSC trans rs731565 1.000 rs1525254 chr7:147406140 C/T cg12847240 chr6:10382088 NA -0.6 -6.61 -0.34 1.51e-10 Diabetic kidney disease; LUSC cis rs6690583 0.623 rs111687161 chr1:85443533 A/G cg22153463 chr1:85462885 MCOLN2 0.63 6.01 0.31 4.83e-9 Serum sulfate level; LUSC cis rs41271951 0.512 rs34761930 chr1:151089523 T/C cg11822372 chr1:151115635 SEMA6C -0.76 -6.95 -0.36 1.98e-11 Blood protein levels; LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg22963979 chr7:1858916 MAD1L1 -0.57 -8.91 -0.44 3.44e-17 Bipolar disorder and schizophrenia; LUSC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg01579765 chr21:45077557 HSF2BP -0.54 -11.47 -0.53 6.71e-26 Mean corpuscular volume; LUSC cis rs12586317 0.620 rs2295104 chr14:35579927 A/G cg05294307 chr14:35346193 BAZ1A 0.53 6.18 0.32 1.87e-9 Psoriasis; LUSC cis rs11971779 0.584 rs10236055 chr7:139069991 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg11752832 chr7:134001865 SLC35B4 0.56 8.8 0.43 7.57e-17 Mean platelet volume; LUSC cis rs12801636 0.512 rs7119750 chr11:65422591 C/T cg26668713 chr11:65405903 SIPA1 0.6 5.94 0.31 7.24e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg03647239 chr10:116582469 FAM160B1 0.48 7.67 0.39 1.96e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1003719 0.646 rs7276711 chr21:38578189 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC cis rs10887741 0.646 rs7097212 chr10:89430067 G/A cg13926569 chr10:89418898 PAPSS2 0.33 7.0 0.36 1.39e-11 Exercise (leisure time); LUSC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg11941060 chr3:133502564 NA -0.51 -7.77 -0.39 1.01e-13 Iron status biomarkers; LUSC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg21361702 chr7:150065534 REPIN1 0.45 6.34 0.33 7.52e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg03264133 chr6:25882463 NA -0.46 -8.69 -0.43 1.67e-16 Blood metabolite levels; LUSC cis rs12476592 0.602 rs262495 chr2:63848607 G/A cg10828910 chr2:63850056 LOC388955 0.48 5.7 0.3 2.69e-8 Childhood ear infection; LUSC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg06134567 chr22:46658398 PKDREJ -0.52 -5.97 -0.31 6.19e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6087990 0.842 rs4911253 chr20:31352585 A/G cg13636640 chr20:31349939 DNMT3B 0.95 19.65 0.73 1.14e-57 Ulcerative colitis; LUSC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg04315214 chr1:2043799 PRKCZ 0.5 10.44 0.5 2.8e-22 Height; LUSC cis rs36096196 0.891 rs12082516 chr1:2251160 C/T cg06784691 chr1:2245988 NA 0.31 5.71 0.3 2.51e-8 Coronary artery disease; LUSC cis rs6541297 0.941 rs6665258 chr1:230279058 G/A cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.22e-15 Coronary artery disease; LUSC cis rs7927592 0.546 rs497261 chr11:68192244 T/C cg01657329 chr11:68192670 LRP5 -0.47 -7.12 -0.36 6.78e-12 Total body bone mineral density; LUSC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg17330251 chr7:94953956 PON1 -0.37 -5.96 -0.31 6.32e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs478304 0.651 rs11604451 chr11:65551710 C/T cg27068330 chr11:65405492 SIPA1 -0.79 -11.26 -0.52 3.84e-25 Acne (severe); LUSC cis rs11677370 0.603 rs1454242 chr2:3848532 G/A cg17052675 chr2:3827356 NA -0.64 -10.2 -0.49 1.87e-21 Type 2 diabetes; LUSC cis rs11098499 0.954 rs3733524 chr4:120423729 T/C cg24375607 chr4:120327624 NA 0.79 11.93 0.55 1.43e-27 Corneal astigmatism; LUSC trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg17830980 chr10:43048298 ZNF37B 0.59 9.77 0.47 5.41e-20 Extrinsic epigenetic age acceleration; LUSC cis rs1878931 0.535 rs7188903 chr16:3412861 A/G cg00484396 chr16:3507460 NAT15 -0.46 -6.75 -0.35 6.7e-11 Body mass index (adult); LUSC cis rs1949733 0.958 rs3103069 chr4:8509451 T/G cg13073564 chr4:8508604 NA 0.47 8.82 0.43 6.58e-17 Response to antineoplastic agents; LUSC cis rs11098499 0.820 rs6534140 chr4:120455311 C/T cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs62238980 0.614 rs76177859 chr22:32390135 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs6733011 0.500 rs2280142 chr2:99434872 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.52 -6.89 -0.35 2.86e-11 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05788437 chr3:197476880 FYTTD1;KIAA0226 0.38 6.6 0.34 1.62e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg17764715 chr19:33622953 WDR88 -0.61 -9.15 -0.45 5.78e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs11098499 0.863 rs3775858 chr4:120486028 A/G cg25214090 chr10:38739885 LOC399744 0.52 7.7 0.39 1.51e-13 Corneal astigmatism; LUSC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -12.01 -0.55 7.05e-28 Extrinsic epigenetic age acceleration; LUSC cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.66 10.17 0.49 2.47e-21 Colorectal cancer; LUSC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg27286337 chr10:134555280 INPP5A 0.88 11.07 0.52 1.79e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 6.75 0.35 6.62e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg18350739 chr11:68623251 NA -0.36 -6.33 -0.33 7.68e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9790314 0.905 rs1154701 chr3:161008025 T/A cg04691961 chr3:161091175 C3orf57 -0.35 -5.97 -0.31 6.09e-9 Morning vs. evening chronotype; LUSC cis rs7210086 0.768 rs4395115 chr17:70640382 G/C cg04206342 chr17:70636940 NA -0.34 -5.76 -0.3 1.92e-8 Ulcerative colitis; LUSC cis rs17253792 0.822 rs75897560 chr14:56090965 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs7119 0.717 rs8032405 chr15:77825344 A/G cg27398640 chr15:77910606 LINGO1 -0.32 -6.78 -0.35 5.49e-11 Type 2 diabetes; LUSC cis rs68170813 0.522 rs12531187 chr7:106963650 C/G cg02696742 chr7:106810147 HBP1 -0.64 -9.46 -0.46 5.6e-19 Coronary artery disease; LUSC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -7.5 -0.38 5.87e-13 Developmental language disorder (linguistic errors); LUSC cis rs9473147 0.516 rs4715018 chr6:47441871 T/C cg20196966 chr6:47445060 CD2AP 0.42 5.75 0.3 1.97e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg24550644 chr17:30846204 MYO1D -0.35 -5.74 -0.3 2.11e-8 Schizophrenia; LUSC cis rs12950390 0.853 rs67441169 chr17:45854462 T/G cg06532163 chr17:45867833 NA 0.34 6.41 0.33 4.93e-10 IgG glycosylation; LUSC cis rs295140 1.000 rs1367856 chr2:201160739 T/A cg04283868 chr2:201171347 SPATS2L 0.44 6.68 0.34 9.75e-11 QT interval; LUSC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg15921436 chr17:44337874 NA 0.74 11.24 0.52 4.32e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg07148914 chr20:33460835 GGT7 0.54 8.28 0.41 2.9e-15 Height; LUSC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg14343924 chr8:8086146 FLJ10661 -0.43 -6.09 -0.32 3.08e-9 Neuroticism; LUSC cis rs1044826 0.642 rs7652860 chr3:139205818 T/A cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.86e-11 Obesity-related traits; LUSC cis rs9815354 0.812 rs73073226 chr3:42005838 T/C cg03022575 chr3:42003672 ULK4 0.81 8.53 0.42 5.02e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9807841 0.592 rs10415961 chr19:10759981 G/C cg17710535 chr19:10819994 QTRT1 0.41 6.67 0.34 1.06e-10 Inflammatory skin disease; LUSC cis rs11122272 0.614 rs78172021 chr1:231525160 A/T cg06096015 chr1:231504339 EGLN1 0.56 10.02 0.48 7.65e-21 Hemoglobin concentration; LUSC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg12823233 chr7:2316876 SNX8 -0.35 -5.8 -0.3 1.52e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg21918786 chr6:109611834 NA -0.4 -6.88 -0.35 2.97e-11 Reticulocyte fraction of red cells; LUSC trans rs445114 0.509 rs386883 chr8:128336871 G/A cg10897648 chr18:56338258 MALT1 -0.42 -6.38 -0.33 5.94e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11526424 chr10:98617461 LCOR -0.66 -5.99 -0.31 5.57e-9 Cognitive performance; LUSC cis rs2361710 0.611 rs12051781 chr17:78074468 A/G cg06718696 chr17:78121285 EIF4A3 0.59 8.84 0.44 5.42e-17 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs12681287 0.547 rs13260345 chr8:87483721 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs868036 0.645 rs4776972 chr15:68083436 A/C cg05925327 chr15:68127851 NA -0.48 -7.03 -0.36 1.19e-11 Restless legs syndrome; LUSC cis rs62400317 0.859 rs62436778 chr6:45120666 A/G cg18551225 chr6:44695536 NA -0.42 -6.8 -0.35 4.79e-11 Total body bone mineral density; LUSC cis rs7223966 1.000 rs11871767 chr17:61698723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.62 0.34 1.4e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1595825 0.891 rs73061069 chr2:198908825 A/G cg00982548 chr2:198649783 BOLL -0.55 -6.97 -0.36 1.69e-11 Ulcerative colitis; LUSC cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg05985134 chr18:33552581 C18orf21 0.49 6.58 0.34 1.86e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs2439831 0.867 rs2412780 chr15:43655794 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.16 0.58 3.88e-32 Lung cancer in ever smokers; LUSC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.89 -0.35 2.73e-11 Lung cancer; LUSC cis rs1003719 0.788 rs1543750 chr21:38446918 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.29 0.53 3e-25 Eye color traits; LUSC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.19 15.48 0.65 4.17e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12926788 0.689 rs7186308 chr16:24848471 A/G cg04756594 chr16:24857601 SLC5A11 0.44 6.37 0.33 6.39e-10 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg18681998 chr4:17616180 MED28 -0.85 -15.85 -0.66 1.44e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg11266682 chr4:10021025 SLC2A9 0.59 10.64 0.5 5.72e-23 Bone mineral density; LUSC trans rs10506458 1.000 rs1495013 chr12:63428188 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -15.56 -0.65 2.01e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs894344 0.584 rs7010948 chr8:135629029 T/C cg27224718 chr8:135614730 ZFAT 0.36 5.83 0.3 1.29e-8 Systolic blood pressure; LUSC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs11785400 0.762 rs2280880 chr8:143721929 C/A cg24634471 chr8:143751801 JRK 0.5 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.45 0.33 3.89e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2048656 0.605 rs13249234 chr8:9650401 T/C cg15556689 chr8:8085844 FLJ10661 0.48 6.69 0.34 9.5e-11 Schizophrenia; LUSC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.5 -0.33 2.99e-10 Coronary artery disease; LUSC cis rs6570726 0.902 rs4895678 chr6:145935510 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.74 -0.3 2.09e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs6500395 1.000 rs7190106 chr16:48705542 C/T cg04672837 chr16:48644449 N4BP1 0.54 8.1 0.41 1.02e-14 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg09699651 chr6:150184138 LRP11 0.46 7.25 0.37 2.89e-12 Testicular germ cell tumor; LUSC cis rs955333 1.000 rs955333 chr6:154947408 A/G cg20019720 chr6:154832845 CNKSR3 0.44 5.73 0.3 2.29e-8 Diabetic kidney disease; LUSC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg06618935 chr21:46677482 NA 0.39 8.13 0.41 8.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.97 0.44 2.22e-17 Prudent dietary pattern; LUSC cis rs868036 0.609 rs13329413 chr15:68097126 C/T cg24579218 chr15:68104479 NA -0.41 -6.69 -0.34 9.3e-11 Restless legs syndrome; LUSC cis rs1348850 0.574 rs10195917 chr2:178443121 C/T cg27490568 chr2:178487706 NA 0.36 5.72 0.3 2.38e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.72 -0.51 3.05e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg18357526 chr6:26021779 HIST1H4A -0.37 -5.79 -0.3 1.6e-8 Intelligence (multi-trait analysis); LUSC cis rs78773383 0.505 rs13123782 chr4:39377405 A/C cg16714752 chr4:39368184 RFC1 0.4 5.81 0.3 1.44e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs240764 0.604 rs9322173 chr6:101203889 G/A cg09795085 chr6:101329169 ASCC3 0.44 6.14 0.32 2.39e-9 Neuroticism; LUSC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg16586182 chr3:47516702 SCAP 0.52 8.08 0.4 1.16e-14 Colorectal cancer; LUSC cis rs3780486 0.846 rs10813950 chr9:33127640 A/G cg13443165 chr9:33130375 B4GALT1 -0.36 -5.7 -0.3 2.61e-8 IgG glycosylation; LUSC cis rs7615316 1.000 rs9856302 chr3:142336361 T/C cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.6e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10892173 0.765 rs1892902 chr11:117669794 T/G cg21640587 chr11:117668038 DSCAML1 0.36 5.82 0.3 1.39e-8 Myopia; LUSC cis rs7005380 0.531 rs7388491 chr8:120925877 G/A cg21744203 chr8:120868354 DSCC1 -0.48 -5.82 -0.3 1.41e-8 Interstitial lung disease; LUSC cis rs7072216 0.763 rs45523432 chr10:100167436 T/C cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15921587 chr2:73144353 EMX1 -0.47 -6.35 -0.33 7.2e-10 Bipolar disorder and schizophrenia; LUSC cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg05738196 chr6:26577821 NA 0.54 8.53 0.42 5.28e-16 Schizophrenia; LUSC cis rs12210905 1.000 rs72838266 chr6:27015052 T/C cg23155468 chr6:27110703 HIST1H2BK -0.7 -5.88 -0.31 1.02e-8 Hip circumference adjusted for BMI; LUSC cis rs9515201 0.859 rs9515199 chr13:111033704 C/T cg05272587 chr13:111038400 COL4A2 0.42 7.12 0.36 6.51e-12 White matter hyperintensity burden; LUSC cis rs7223966 1.000 rs7209758 chr17:61913621 C/T cg05941027 chr17:61774174 LIMD2 0.22 5.84 0.3 1.23e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs734999 0.545 rs41300092 chr1:2537838 C/T cg18854424 chr1:2615690 NA 0.51 10.18 0.49 2.18e-21 Ulcerative colitis; LUSC cis rs1023500 0.551 rs61665536 chr22:42512613 A/G cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Schizophrenia; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg18404041 chr3:52824283 ITIH1 -0.59 -9.97 -0.48 1.17e-20 Bipolar disorder; LUSC cis rs1215050 0.791 rs260890 chr4:98741698 A/G cg05340658 chr4:99064831 C4orf37 0.42 6.78 0.35 5.34e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs7695114 chr4:97968711 C/T cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4919087 1.000 rs61863767 chr10:99084426 C/T cg25902810 chr10:99078978 FRAT1 0.51 7.58 0.38 3.46e-13 Monocyte count; LUSC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg13390004 chr1:15929781 NA 0.39 6.48 0.33 3.31e-10 Systolic blood pressure; LUSC cis rs7647973 1.000 rs11719762 chr3:49409002 G/C cg07636037 chr3:49044803 WDR6 0.71 9.64 0.47 1.48e-19 Menarche (age at onset); LUSC trans rs7618501 0.602 rs2624853 chr3:50128893 A/G cg21659725 chr3:3221576 CRBN -0.64 -10.41 -0.49 3.65e-22 Intelligence (multi-trait analysis); LUSC cis rs7223966 1.000 rs7220821 chr17:61704147 G/A cg05941027 chr17:61774174 LIMD2 0.23 6.13 0.32 2.52e-9 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs1997103 1.000 rs6593233 chr7:55406200 C/T cg20935933 chr6:143382018 AIG1 -0.5 -7.26 -0.37 2.74e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs11971779 0.553 rs7799742 chr7:139051878 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg16624210 chr5:671434 TPPP 0.48 6.07 0.32 3.42e-9 Obesity-related traits; LUSC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.34e-11 Melanoma; LUSC cis rs17401966 0.931 rs3737155 chr1:10459779 G/A cg19773385 chr1:10388646 KIF1B -0.57 -9.61 -0.47 1.81e-19 Hepatocellular carcinoma; LUSC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg14784868 chr12:69753453 YEATS4 -0.9 -16.35 -0.67 1.45e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg13736514 chr6:26305472 NA 0.45 9.03 0.44 1.44e-17 Educational attainment; LUSC cis rs3087591 0.659 rs757376 chr17:29717909 A/G cg24425628 chr17:29625626 OMG;NF1 0.47 7.08 0.36 8.33e-12 Hip circumference; LUSC cis rs1124376 0.816 rs62243131 chr3:20141308 A/G cg05072819 chr3:20081367 KAT2B 0.65 7.63 0.39 2.51e-13 Bipolar disorder and schizophrenia; LUSC cis rs12801636 0.846 rs1078457 chr11:65380124 C/T cg16535667 chr11:65410126 SIPA1 -0.48 -5.95 -0.31 6.66e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.68 -0.39 1.74e-13 Triglycerides; LUSC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs9892942 1 rs9892942 chr17:27178761 C/T cg19789473 chr17:27170043 C17orf63 -0.29 -5.67 -0.3 3.13e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2742234 0.590 rs741968 chr10:43611708 A/G cg02780029 chr10:43622663 RET -0.35 -5.85 -0.3 1.16e-8 Hirschsprung disease; LUSC cis rs7267979 1.000 rs1077889 chr20:25267893 A/G cg08601574 chr20:25228251 PYGB 0.43 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3862030 0.720 rs7081110 chr10:104231651 A/G cg22532475 chr10:104410764 TRIM8 0.24 5.64 0.3 3.58e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs11792861 0.926 rs72607174 chr9:111899132 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 8.55 0.42 4.46e-16 Menarche (age at onset); LUSC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg20503657 chr10:835505 NA 1.19 16.28 0.67 2.87e-44 Eosinophil percentage of granulocytes; LUSC trans rs561341 0.882 rs504887 chr17:30322881 T/A cg20587970 chr11:113659929 NA -1.28 -17.56 -0.69 2.31e-49 Hip circumference adjusted for BMI; LUSC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg02534363 chr3:47050950 NBEAL2 -0.37 -5.97 -0.31 6.06e-9 Colorectal cancer; LUSC cis rs7824557 0.527 rs10109537 chr8:11239640 C/T cg21775007 chr8:11205619 TDH -0.67 -10.57 -0.5 9.86e-23 Retinal vascular caliber; LUSC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg02269571 chr22:50332266 NA -0.57 -8.54 -0.42 4.87e-16 Schizophrenia; LUSC cis rs78366141 0.649 rs7674009 chr4:89683324 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 -0.84 -7.28 -0.37 2.44e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs74544699 1.000 rs11574452 chr4:74846661 A/C cg02530824 chr4:74847766 PF4 -0.77 -5.67 -0.3 3.07e-8 Growth-regulated protein alpha levels; LUSC cis rs9660992 0.649 rs72745216 chr1:205261016 G/A cg21643547 chr1:205240462 TMCC2 -0.49 -9.3 -0.45 1.88e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4478858 0.684 rs10798839 chr1:31731758 C/G cg00250761 chr1:31883323 NA -0.33 -7.86 -0.4 5.29e-14 Alcohol dependence; LUSC cis rs2996428 0.667 rs7545274 chr1:3744261 G/T cg23277830 chr1:3704460 LRRC47 0.34 6.38 0.33 5.9e-10 Red cell distribution width; LUSC cis rs1729951 0.575 rs1654926 chr3:136709924 G/A cg12473912 chr3:136751656 NA 0.39 6.94 0.36 2.03e-11 Neuroticism; LUSC cis rs10875746 0.951 rs11168433 chr12:48558064 C/G cg13454099 chr12:49076203 C12orf41 -0.52 -6.08 -0.32 3.33e-9 Longevity (90 years and older); LUSC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg18850127 chr7:39170497 POU6F2 0.69 10.98 0.51 3.81e-24 IgG glycosylation; LUSC trans rs2836974 0.613 rs2245455 chr21:40548087 A/T cg26149032 chr3:158519514 MFSD1 -0.37 -6.08 -0.32 3.28e-9 Cognitive function; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg03188948 chr7:1209495 NA 0.45 6.88 0.35 2.97e-11 Longevity;Endometriosis; LUSC cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg23711669 chr6:146136114 FBXO30 0.82 14.38 0.62 8.11e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs892961 0.932 rs55661113 chr17:75408386 A/C cg05865280 chr17:75406074 SEPT9 0.43 9.12 0.45 7.04e-18 Airflow obstruction; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03447080 chr4:142142038 ZNF330 0.43 6.49 0.33 3.16e-10 Asthma; LUSC cis rs477692 0.685 rs551491 chr10:131397821 G/A cg05714579 chr10:131428358 MGMT 0.49 7.1 0.36 7.7e-12 Response to temozolomide; LUSC trans rs7829975 0.714 rs7823757 chr8:8670177 T/A cg27411982 chr8:10470053 RP1L1 0.43 6.86 0.35 3.37e-11 Mood instability; LUSC cis rs6089584 0.508 rs6061988 chr20:60626300 C/T cg24733560 chr20:60626293 TAF4 0.43 7.76 0.39 1.07e-13 Body mass index; LUSC cis rs11098499 0.615 rs28551750 chr4:120264901 C/T cg09307838 chr4:120376055 NA 0.64 9.67 0.47 1.19e-19 Corneal astigmatism; LUSC cis rs2235544 0.588 rs662603 chr1:54467767 T/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs11098499 0.730 rs78971550 chr4:120281041 C/T cg09307838 chr4:120376055 NA 0.69 10.03 0.48 7.01e-21 Corneal astigmatism; LUSC cis rs7131987 0.903 rs10843373 chr12:29420608 A/T cg09582351 chr12:29534625 ERGIC2 -0.31 -6.39 -0.33 5.44e-10 QT interval; LUSC cis rs7647973 1.000 rs62259944 chr3:49430883 G/A cg07636037 chr3:49044803 WDR6 -0.67 -8.53 -0.42 5.25e-16 Menarche (age at onset); LUSC cis rs7605827 0.930 rs10168299 chr2:15615063 A/G cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs2652834 0.851 rs2652820 chr15:63430901 T/C cg05507819 chr15:63340323 TPM1 0.47 6.04 0.31 4.08e-9 HDL cholesterol; LUSC cis rs11098499 0.954 rs6822679 chr4:120402702 A/C cg24375607 chr4:120327624 NA 0.79 11.91 0.55 1.72e-27 Corneal astigmatism; LUSC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg08859206 chr1:53392774 SCP2 -0.38 -6.46 -0.33 3.72e-10 Monocyte count; LUSC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg03806693 chr22:41940476 POLR3H -0.94 -12.62 -0.57 4.05e-30 Vitiligo; LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.54 -0.42 4.67e-16 Bipolar disorder; LUSC cis rs2502731 1.000 rs2502731 chr9:130976557 A/G cg09976142 chr9:130955436 CIZ1 -0.53 -9.22 -0.45 3.5e-18 Attention deficit hyperactivity disorder; LUSC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg06108461 chr20:60628389 TAF4 -0.99 -16.76 -0.68 3.51e-46 Body mass index; LUSC cis rs2439831 1.000 rs7173487 chr15:43750239 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.42 0.42 1.09e-15 Lung cancer in ever smokers; LUSC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.75 0.35 6.62e-11 Platelet count; LUSC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg20607287 chr7:12443886 VWDE -0.65 -6.44 -0.33 4.12e-10 Coronary artery disease; LUSC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.913 rs2236708 chr11:68378045 G/A cg20283391 chr11:68216788 NA -0.59 -8.18 -0.41 5.9e-15 Total body bone mineral density; LUSC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg07936489 chr17:37558343 FBXL20 0.72 9.94 0.48 1.47e-20 Glomerular filtration rate (creatinine); LUSC trans rs2243480 1.000 rs10247526 chr7:65780696 T/G cg10756647 chr7:56101905 PSPH -0.86 -8.52 -0.42 5.52e-16 Diabetic kidney disease; LUSC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg07636037 chr3:49044803 WDR6 1.03 17.83 0.7 1.9e-50 Parkinson's disease; LUSC cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg05347473 chr6:146136440 FBXO30 0.39 6.61 0.34 1.53e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7923609 0.902 rs10740136 chr10:65329622 A/C cg01631684 chr10:65280961 REEP3 -0.42 -6.59 -0.34 1.77e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7119038 0.818 rs56043232 chr11:118648373 C/T cg19308663 chr11:118741387 NA 0.37 6.33 0.33 7.82e-10 Sjögren's syndrome; LUSC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.2 0.52 6.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4808199 1.000 rs12977524 chr19:19568244 A/G cg03709012 chr19:19516395 GATAD2A 1.12 14.83 0.63 1.36e-38 Nonalcoholic fatty liver disease; LUSC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg08270630 chr22:50330655 NA 0.4 5.9 0.31 9.13e-9 Schizophrenia; LUSC cis rs2274273 0.554 rs3742564 chr14:55530120 C/T cg04306507 chr14:55594613 LGALS3 -0.48 -10.34 -0.49 6.38e-22 Protein biomarker; LUSC trans rs7826238 0.509 rs2948288 chr8:8115304 A/G cg21775007 chr8:11205619 TDH 0.5 7.2 0.37 3.9e-12 Systolic blood pressure; LUSC cis rs2607426 0.681 rs1455434 chr19:41257046 G/T cg05508168 chr19:41255947 C19orf54;SNRPA 0.89 6.29 0.33 9.68e-10 Blood protein levels; LUSC cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg24642439 chr20:33292090 TP53INP2 0.47 7.18 0.37 4.46e-12 Glomerular filtration rate (creatinine); LUSC cis rs17824933 0.848 rs74860834 chr11:60778513 T/C cg16817237 chr11:60793675 NA 0.39 6.17 0.32 1.98e-9 Multiple sclerosis; LUSC cis rs6087990 0.735 rs910083 chr20:31378690 A/C cg13636640 chr20:31349939 DNMT3B 0.91 18.53 0.71 3.14e-53 Ulcerative colitis; LUSC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg08219700 chr8:58056026 NA 0.69 8.02 0.4 1.79e-14 Developmental language disorder (linguistic errors); LUSC cis rs6565180 1.000 rs68051857 chr16:30360011 A/G cg17640201 chr16:30407289 ZNF48 -0.87 -15.42 -0.64 6.95e-41 Tonsillectomy; LUSC cis rs1185460 0.934 rs10892328 chr11:118942654 T/A cg23280166 chr11:118938394 VPS11 0.46 6.79 0.35 5.2e-11 Coronary artery disease; LUSC cis rs7954584 0.567 rs11612028 chr12:122387872 C/G cg21171335 chr12:122356390 WDR66 0.64 9.64 0.47 1.45e-19 Mean corpuscular volume; LUSC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg00509249 chr6:109615579 CCDC162 -0.32 -5.74 -0.3 2.17e-8 Reticulocyte fraction of red cells; LUSC cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg23711669 chr6:146136114 FBXO30 0.76 13.53 0.6 1.43e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg23172400 chr8:95962367 TP53INP1 -0.4 -7.82 -0.39 6.95e-14 Type 2 diabetes; LUSC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.23 -0.32 1.39e-9 Neutrophil percentage of white cells; LUSC cis rs3126085 0.935 rs12760382 chr1:152260287 G/T cg26876637 chr1:152193138 HRNR -0.44 -5.91 -0.31 8.63e-9 Atopic dermatitis; LUSC cis rs155346 1.000 rs265142 chr5:139396998 C/T cg01090482 chr5:139365336 NRG2 -0.37 -6.07 -0.32 3.5e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg14019146 chr3:50243930 SLC38A3 0.36 8.27 0.41 3.11e-15 Body mass index; LUSC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg12927641 chr6:109611667 NA -0.35 -5.88 -0.31 1.01e-8 Reticulocyte fraction of red cells; LUSC trans rs2797160 0.967 rs6910786 chr6:126017141 A/T cg05039488 chr6:79577232 IRAK1BP1 0.46 6.85 0.35 3.55e-11 Endometrial cancer; LUSC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg06008330 chr7:65541103 ASL 0.41 6.32 0.33 8.55e-10 Aortic root size; LUSC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7674212 0.541 rs2623070 chr4:104037388 A/G cg16532752 chr4:104119610 CENPE 0.48 6.63 0.34 1.36e-10 Type 2 diabetes; LUSC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.45 6.39 0.33 5.47e-10 Osteoporosis; LUSC cis rs4853525 0.522 rs7574840 chr2:191584236 C/G cg11845111 chr2:191398756 TMEM194B -0.42 -5.66 -0.3 3.24e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs8060686 0.545 rs12597573 chr16:68167521 A/C cg09835421 chr16:68378352 PRMT7 0.62 6.48 0.33 3.26e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08898568 chr1:17338409 ATP13A2 -0.41 -6.32 -0.33 8.36e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg04518342 chr5:131593106 PDLIM4 0.45 8.26 0.41 3.5e-15 Breast cancer; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg08200582 chr11:442649 ANO9 -0.5 -5.7 -0.3 2.7e-8 Body mass index; LUSC cis rs10911251 0.509 rs4652780 chr1:183105923 G/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.51e-22 Colorectal cancer; LUSC cis rs9837602 0.810 rs35885423 chr3:99813218 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.43 -6.13 -0.32 2.47e-9 Breast cancer; LUSC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.46 -9.9 -0.48 1.96e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -8.76 -0.43 9.87e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2276314 1.000 rs2298716 chr18:33552598 C/T cg05985134 chr18:33552581 C18orf21 0.51 6.95 0.36 1.89e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 12.24 0.56 1.05e-28 Hip circumference adjusted for BMI; LUSC cis rs422249 0.547 rs174535 chr11:61551356 T/C cg19610905 chr11:61596333 FADS2 -0.53 -7.95 -0.4 2.88e-14 Trans fatty acid levels; LUSC trans rs1325195 0.920 rs2793797 chr1:179097206 A/G cg11624085 chr17:8464688 MYH10 0.44 7.4 0.38 1.1e-12 IgE grass sensitization; LUSC cis rs9467773 0.869 rs1796521 chr6:26421392 T/C cg11502198 chr6:26597334 ABT1 -0.48 -6.73 -0.35 7.59e-11 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg16434002 chr17:42200994 HDAC5 0.45 6.25 0.32 1.27e-9 Total body bone mineral density; LUSC trans rs2243480 1.000 rs1701758 chr7:65470201 T/A cg10756647 chr7:56101905 PSPH 0.85 8.28 0.41 3.01e-15 Diabetic kidney disease; LUSC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg27121462 chr16:89883253 FANCA 0.56 9.01 0.44 1.57e-17 Vitiligo; LUSC cis rs694739 0.894 rs887314 chr11:64053157 T/G cg26898376 chr11:64110657 CCDC88B 0.36 6.7 0.34 8.64e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg21548813 chr6:291882 DUSP22 -0.52 -7.84 -0.39 6.12e-14 Menopause (age at onset); LUSC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg06850241 chr22:41845214 NA -0.3 -5.71 -0.3 2.46e-8 Vitiligo; LUSC trans rs61931739 0.929 rs3912551 chr12:34076696 C/T cg13010199 chr12:38710504 ALG10B -0.46 -7.4 -0.38 1.15e-12 Morning vs. evening chronotype; LUSC cis rs79149102 0.579 rs74023936 chr15:75362084 C/T cg09165964 chr15:75287851 SCAMP5 -0.75 -6.85 -0.35 3.48e-11 Lung cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19182908 chr22:38204192 GCAT 0.4 6.02 0.31 4.64e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg15155738 chr12:121454335 C12orf43 0.42 5.83 0.3 1.29e-8 N-glycan levels; LUSC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.64 8.08 0.4 1.21e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs4629710 0.645 rs35561719 chr6:131551244 G/A cg12606694 chr6:131520996 AKAP7 0.62 9.37 0.46 1.12e-18 Multiple myeloma (IgH translocation); LUSC cis rs8077889 0.917 rs28694735 chr17:41912144 A/G cg26893861 chr17:41843967 DUSP3 0.87 13.45 0.59 2.87e-33 Triglycerides; LUSC trans rs11098499 0.954 rs10008392 chr4:120318839 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.08e-14 Corneal astigmatism; LUSC cis rs9399135 0.935 rs949547 chr6:135343499 C/G cg22676075 chr6:135203613 NA 0.47 7.4 0.38 1.12e-12 Red blood cell count; LUSC cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg23711669 chr6:146136114 FBXO30 0.73 12.96 0.58 2.13e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg04414720 chr1:150670196 GOLPH3L 0.56 9.06 0.44 1.14e-17 Tonsillectomy; LUSC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg22532475 chr10:104410764 TRIM8 -0.34 -7.58 -0.38 3.48e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg07606381 chr6:8435919 SLC35B3 0.75 12.61 0.57 4.55e-30 Motion sickness; LUSC cis rs9392556 0.829 rs9328220 chr6:4120181 A/C cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.21 -0.32 1.58e-9 Blood metabolite levels; LUSC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg17554472 chr22:41940697 POLR3H 0.47 5.73 0.3 2.22e-8 Vitiligo; LUSC cis rs11785693 0.862 rs11786657 chr8:5001792 T/C cg26367366 chr8:4980734 NA 0.73 8.36 0.42 1.71e-15 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs73195822 0.667 rs73194055 chr12:111216292 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 6.59 0.34 1.76e-10 Itch intensity from mosquito bite; LUSC cis rs2109514 1.000 rs2270189 chr7:116140616 A/G cg12739419 chr7:116140593 CAV2 -0.29 -6.3 -0.33 9.14e-10 Prevalent atrial fibrillation; LUSC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg08219700 chr8:58056026 NA 0.66 7.44 0.38 8.4e-13 Developmental language disorder (linguistic errors); LUSC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg14456004 chr13:21872349 NA 0.43 6.02 0.31 4.68e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs3540 0.618 rs2301832 chr15:91040725 A/T cg22089800 chr15:90895588 ZNF774 -0.64 -9.63 -0.47 1.61e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg02038168 chr22:39784481 NA 0.47 7.76 0.39 1.05e-13 Intelligence (multi-trait analysis); LUSC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg23590916 chr17:43697445 MGC57346 -0.49 -6.68 -0.34 1e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs10435719 0.902 rs7014580 chr8:11803262 C/G cg27411982 chr8:10470053 RP1L1 0.41 6.37 0.33 6.2e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7399018 0.739 rs7953955 chr12:51608467 A/G cg12163867 chr12:51592794 POU6F1 -0.47 -8.67 -0.43 1.87e-16 Cisplatin-induced ototoxicity; LUSC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg18827107 chr12:86230957 RASSF9 -0.44 -6.61 -0.34 1.55e-10 Major depressive disorder; LUSC cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg14664628 chr15:75095509 CSK 0.43 6.25 0.32 1.27e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg24977027 chr2:88469347 THNSL2 0.56 5.97 0.31 6.18e-9 Plasma clusterin levels; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg19318889 chr4:1322082 MAEA 0.48 7.79 0.39 8.41e-14 Obesity-related traits; LUSC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.97 -0.31 6.13e-9 Intelligence (multi-trait analysis); LUSC cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg23583168 chr7:148888333 NA -0.8 -13.32 -0.59 9.35e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs35110281 0.622 rs9977258 chr21:44976485 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.74 0.54 7.04e-27 Mean corpuscular volume; LUSC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.16 0.36 5.25e-12 Major depressive disorder; LUSC cis rs778371 0.752 rs283487 chr2:233644011 A/G cg08000102 chr2:233561755 GIGYF2 0.78 12.39 0.56 2.88e-29 Schizophrenia; LUSC trans rs10096351 0.574 rs684254 chr8:128338693 G/A cg10897648 chr18:56338258 MALT1 -0.42 -6.35 -0.33 6.95e-10 Breast cancer; LUSC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.07e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9581857 0.556 rs9581861 chr13:28039991 C/T cg22138327 chr13:27999177 GTF3A 0.7 9.5 0.46 4.1e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs11190604 1.000 rs10883512 chr10:102308516 A/G cg16342193 chr10:102329863 NA -0.37 -6.65 -0.34 1.22e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg19824325 chr16:58548873 SETD6 0.94 9.15 0.45 5.56e-18 Schizophrenia; LUSC cis rs6546550 0.901 rs6725425 chr2:70150674 T/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06850241 chr22:41845214 NA -0.31 -6.04 -0.31 4.02e-9 Vitiligo; LUSC cis rs7829975 0.782 rs6990746 chr8:8547811 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.42 -0.46 7.95e-19 Mood instability; LUSC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg18827107 chr12:86230957 RASSF9 -0.46 -6.7 -0.34 8.87e-11 Major depressive disorder; LUSC cis rs7267979 0.816 rs8115257 chr20:25207931 A/G cg08601574 chr20:25228251 PYGB 0.55 8.84 0.44 5.56e-17 Liver enzyme levels (alkaline phosphatase); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15937634 chr12:122459934 BCL7A 0.45 6.07 0.32 3.5e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9905704 0.633 rs2021733 chr17:56489168 C/T cg19466818 chr17:56409534 MIR142 0.32 6.06 0.31 3.73e-9 Testicular germ cell tumor; LUSC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg10523679 chr1:76189770 ACADM 0.87 14.11 0.61 8.79e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9303401 0.615 rs7502342 chr17:56922629 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.35 0.59 7.08e-33 Cognitive test performance; LUSC cis rs73198271 0.530 rs11778326 chr8:8651566 T/G cg01851573 chr8:8652454 MFHAS1 0.6 8.1 0.41 1.03e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg11752832 chr7:134001865 SLC35B4 -0.51 -7.73 -0.39 1.29e-13 Mean platelet volume; LUSC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.9 -0.63 7.32e-39 Total body bone mineral density; LUSC cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg08807101 chr21:30365312 RNF160 -0.54 -8.2 -0.41 5.09e-15 Dental caries; LUSC cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.79 -0.3 1.66e-8 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg18681998 chr4:17616180 MED28 0.79 13.56 0.6 1.14e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg16325326 chr1:53192061 ZYG11B -1.0 -20.14 -0.74 1.24e-59 Monocyte count; LUSC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg11663144 chr21:46675770 NA -0.46 -8.24 -0.41 3.91e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9393692 0.627 rs2179517 chr6:26198845 G/C cg13736514 chr6:26305472 NA -0.36 -6.71 -0.34 8.54e-11 Educational attainment; LUSC cis rs10740039 0.732 rs10160182 chr10:62362451 A/C cg18175470 chr10:62150864 ANK3 -0.46 -6.87 -0.35 3.23e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9905704 0.681 rs2108911 chr17:56570500 C/T cg19466818 chr17:56409534 MIR142 0.39 7.34 0.37 1.68e-12 Testicular germ cell tumor; LUSC cis rs12541635 0.966 rs34177605 chr8:107065105 G/A cg10147462 chr8:107024639 NA 0.55 9.81 0.47 3.91e-20 Age of smoking initiation; LUSC trans rs2243480 1.000 rs7795242 chr7:65390094 T/C cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs6429082 0.818 rs210037 chr1:235649501 A/G cg26050004 chr1:235667680 B3GALNT2 0.61 8.34 0.41 2.03e-15 Adiposity; LUSC cis rs6424115 1.000 rs35385477 chr1:24155924 G/A cg15997130 chr1:24165203 NA 0.53 8.68 0.43 1.81e-16 Immature fraction of reticulocytes; LUSC cis rs7681440 0.904 rs35424815 chr4:90767877 C/T cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg00376283 chr12:123451042 ABCB9 0.7 9.84 0.47 3.03e-20 Neutrophil percentage of white cells; LUSC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg03351412 chr1:154909251 PMVK 0.4 6.03 0.31 4.28e-9 Prostate cancer; LUSC cis rs6967385 0.560 rs10272105 chr7:12358122 C/A cg06484146 chr7:12443880 VWDE 0.45 6.66 0.34 1.14e-10 Response to taxane treatment (placlitaxel); LUSC trans rs4650994 0.525 rs17361286 chr1:178521916 C/G cg05059571 chr16:84539110 KIAA1609 -0.47 -8.92 -0.44 3.11e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 14.27 0.62 2.13e-36 Platelet count; LUSC cis rs17102423 0.594 rs10151162 chr14:65566695 T/C cg11161011 chr14:65562177 MAX -0.72 -11.0 -0.52 3.28e-24 Obesity-related traits; LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg25072359 chr17:41440525 NA 0.66 9.34 0.45 1.43e-18 Menopause (age at onset); LUSC cis rs2717559 0.542 rs11777634 chr8:143887957 C/T cg02415014 chr8:143852576 LYNX1 0.32 7.37 0.37 1.36e-12 Urinary tract infection frequency; LUSC cis rs3020736 0.500 rs6519306 chr22:42501217 T/C cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.49 -0.59 2.14e-33 Alzheimer's disease; LUSC cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg17143192 chr8:8559678 CLDN23 0.63 9.07 0.44 1.02e-17 Obesity-related traits; LUSC cis rs6964587 0.626 rs10225241 chr7:91524940 A/G cg17063962 chr7:91808500 NA -0.56 -9.27 -0.45 2.45e-18 Breast cancer; LUSC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.58 0.34 1.83e-10 Lung cancer; LUSC cis rs7143963 1.000 rs4906267 chr14:103305077 G/T cg21920469 chr14:103375193 NA -0.43 -5.77 -0.3 1.85e-8 Body mass index; LUSC cis rs12208915 0.767 rs12208017 chr6:79823371 G/T cg05283184 chr6:79620031 NA -0.4 -5.93 -0.31 7.51e-9 Left atrial antero-posterior diameter; LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg02073558 chr3:44770973 ZNF501 0.53 8.8 0.43 7.43e-17 Depressive symptoms; LUSC cis rs7246967 0.611 rs62118823 chr19:22844066 A/G cg23217946 chr19:22817039 ZNF492 0.48 6.17 0.32 1.95e-9 Bronchopulmonary dysplasia; LUSC cis rs2797160 0.967 rs1739358 chr6:126019736 G/A cg05901451 chr6:126070800 HEY2 0.57 8.51 0.42 5.79e-16 Endometrial cancer; LUSC cis rs61990749 0.597 rs12887282 chr14:78200585 C/A cg02301378 chr14:78227641 SNW1;C14orf178 0.59 6.44 0.33 4.08e-10 Fibroblast growth factor basic levels; LUSC cis rs10203711 0.932 rs4353597 chr2:239597772 C/G cg14580085 chr2:239553406 NA 0.42 7.15 0.36 5.56e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs113835537 0.529 rs10896125 chr11:66288733 G/C cg24851651 chr11:66362959 CCS 0.53 7.97 0.4 2.58e-14 Airway imaging phenotypes; LUSC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg18876405 chr7:65276391 NA -0.68 -11.78 -0.54 4.97e-27 Calcium levels; LUSC trans rs8002861 0.967 rs7999434 chr13:44482961 T/C cg17145862 chr1:211918768 LPGAT1 0.23 6.1 0.32 2.97e-9 Leprosy; LUSC cis rs6430585 0.528 rs309152 chr2:136657252 C/T cg07169764 chr2:136633963 MCM6 -0.92 -14.19 -0.61 4.37e-36 Corneal structure; LUSC cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.5 -0.46 4.24e-19 Chronic sinus infection; LUSC cis rs13315871 0.929 rs73835170 chr3:58318448 A/G cg20936604 chr3:58311152 NA -0.72 -6.92 -0.35 2.36e-11 Cholesterol, total; LUSC trans rs12210905 0.925 rs7753284 chr6:26991615 G/C cg11837749 chr1:55047332 ACOT11 0.57 6.13 0.32 2.51e-9 Hip circumference adjusted for BMI; LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg24675658 chr1:53192096 ZYG11B -0.56 -8.61 -0.43 2.86e-16 Monocyte count; LUSC cis rs6961069 0.585 rs1464792 chr7:80243252 T/C cg04458919 chr7:80252533 CD36 -0.39 -6.91 -0.35 2.42e-11 Platelet count; LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg13047869 chr3:10149882 C3orf24 0.64 8.22 0.41 4.62e-15 Alzheimer's disease; LUSC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg03806693 chr22:41940476 POLR3H 0.99 14.14 0.61 6.88e-36 Vitiligo; LUSC trans rs853679 0.517 rs9380061 chr6:28132803 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs67460515 0.892 rs73026976 chr3:160964271 G/A cg03342759 chr3:160939853 NMD3 -0.55 -8.04 -0.4 1.62e-14 Parkinson's disease; LUSC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg23985595 chr17:80112537 CCDC57 0.3 5.78 0.3 1.69e-8 Life satisfaction; LUSC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg17279839 chr7:150038598 RARRES2 0.45 7.05 0.36 1.03e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2120019 1.000 rs2415255 chr15:75332412 A/G cg11632617 chr15:75315747 PPCDC -0.5 -6.45 -0.33 4.03e-10 Blood trace element (Zn levels); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg22072063 chr11:73087715 RELT 0.42 6.2 0.32 1.71e-9 Mosquito bite size; LUSC cis rs8017423 0.565 rs4904681 chr14:90835566 A/T cg04374321 chr14:90722782 PSMC1 -0.42 -6.17 -0.32 2.03e-9 Mortality in heart failure; LUSC cis rs3738772 0.633 rs919958 chr1:110053148 C/G cg08367326 chr1:110052010 AMIGO1 -0.48 -7.19 -0.37 4.2e-12 Intelligence (multi-trait analysis); LUSC cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.74 11.89 0.55 2.07e-27 Colorectal cancer; LUSC cis rs9308433 0.553 rs9308435 chr1:214500166 C/T cg06198575 chr1:214491504 SMYD2 0.45 6.96 0.36 1.83e-11 IgG glycosylation; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg14792983 chr20:18447909 C20orf12;POLR3F 0.52 6.09 0.32 3.07e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6681460 0.549 rs7547857 chr1:67031890 A/G cg02459107 chr1:67143332 SGIP1 0.31 5.69 0.3 2.85e-8 Presence of antiphospholipid antibodies; LUSC cis rs16854884 0.657 rs6783089 chr3:143738034 T/C cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs137603 0.644 rs137620 chr22:39709776 T/C cg17798944 chr22:39715225 SNORD43;RPL3 -0.52 -8.19 -0.41 5.76e-15 Primary biliary cholangitis; LUSC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg08798685 chr6:27730294 NA -0.66 -6.19 -0.32 1.8e-9 Depression; LUSC cis rs4443100 0.958 rs9620213 chr22:23395411 A/C cg21100191 chr22:23484243 RTDR1 0.5 6.09 0.32 3.11e-9 Serum parathyroid hormone levels; LUSC cis rs7954584 0.531 rs6486781 chr12:122318985 A/C cg21016266 chr12:122356598 WDR66 0.56 8.07 0.4 1.26e-14 Mean corpuscular volume; LUSC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.98 0.44 1.95e-17 Menopause (age at onset); LUSC cis rs1801251 1.000 rs3816334 chr2:233708806 A/G cg25237894 chr2:233734115 C2orf82 -0.36 -6.81 -0.35 4.61e-11 Coronary artery disease; LUSC cis rs4595586 0.545 rs7980848 chr12:39375166 G/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs708547 0.874 rs1630798 chr4:57883558 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 9.02 0.44 1.52e-17 Response to bleomycin (chromatid breaks); LUSC cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.59 -0.43 3.49e-16 Axial length; LUSC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.42 6.5 0.34 2.93e-10 Intelligence (multi-trait analysis); LUSC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg09165964 chr15:75287851 SCAMP5 -1.01 -15.29 -0.64 2.16e-40 Blood trace element (Zn levels); LUSC cis rs478304 0.651 rs11227281 chr11:65496558 T/C cg27068330 chr11:65405492 SIPA1 -0.76 -10.88 -0.51 8.57e-24 Acne (severe); LUSC cis rs9309473 0.539 rs7574268 chr2:73904872 C/T cg20560298 chr2:73613845 ALMS1 0.46 6.89 0.35 2.72e-11 Metabolite levels; LUSC trans rs9393366 0.598 rs10456272 chr6:23154345 A/G cg01144275 chr17:79478508 ACTG1 0.45 6.0 0.31 5.22e-9 Tourette syndrome; LUSC cis rs11690935 0.877 rs13024846 chr2:172835803 C/T cg13550731 chr2:172543902 DYNC1I2 -0.86 -14.14 -0.61 6.56e-36 Schizophrenia; LUSC cis rs28374715 0.783 rs11630656 chr15:41570909 T/G cg18705301 chr15:41695430 NDUFAF1 -1.01 -20.2 -0.74 7.19e-60 Ulcerative colitis; LUSC trans rs9951602 0.512 rs61021837 chr18:76648210 A/C cg02800362 chr5:177631904 HNRNPAB 0.89 13.13 0.58 5.06e-32 Obesity-related traits; LUSC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg12292205 chr6:26970375 C6orf41 -0.69 -12.15 -0.55 2.25e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs6714710 0.603 rs34974566 chr2:98552299 C/G cg26665480 chr2:98280029 ACTR1B 0.6 8.76 0.43 9.72e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg04267008 chr7:1944627 MAD1L1 -0.51 -7.64 -0.39 2.31e-13 Bipolar disorder and schizophrenia; LUSC trans rs73193808 0.639 rs2832237 chr21:30547683 C/G cg14791747 chr16:20752902 THUMPD1 -0.46 -6.23 -0.32 1.42e-9 Coronary artery disease; LUSC cis rs9303542 0.512 rs67412921 chr17:46636625 C/A cg09704116 chr17:46666958 LOC404266 -0.38 -6.02 -0.31 4.54e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg08677398 chr8:58056175 NA 0.54 6.65 0.34 1.23e-10 Developmental language disorder (linguistic errors); LUSC cis rs929354 1.000 rs1182385 chr7:157040583 C/T cg17757837 chr7:157058334 UBE3C -0.9 -15.07 -0.64 1.6e-39 Body mass index; LUSC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg17264618 chr3:40429014 ENTPD3 -0.3 -6.63 -0.34 1.36e-10 Renal cell carcinoma; LUSC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg03264133 chr6:25882463 NA 0.52 9.58 0.46 2.29e-19 Blood metabolite levels; LUSC cis rs9902453 0.933 rs7221154 chr17:28505024 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.51 -8.02 -0.4 1.76e-14 Coffee consumption (cups per day); LUSC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg18302933 chr2:88491318 NA -0.36 -6.19 -0.32 1.81e-9 Response to metformin (IC50); LUSC cis rs950169 0.922 rs12910334 chr15:84958318 G/A cg12863693 chr15:85201151 NMB 0.37 7.32 0.37 1.87e-12 Schizophrenia; LUSC trans rs2018683 0.870 rs13232487 chr7:28985119 C/A cg19402173 chr7:128379420 CALU -0.55 -8.66 -0.43 2.04e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.43e-32 Chronic sinus infection; LUSC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg08270630 chr22:50330655 NA -0.45 -6.64 -0.34 1.25e-10 Schizophrenia; LUSC cis rs12900463 0.813 rs186266 chr15:85402795 A/G cg17173187 chr15:85201210 NMB 0.32 5.76 0.3 1.96e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); LUSC cis rs6845621 0.901 rs1377153 chr4:18923066 A/G cg12196642 chr4:18937545 NA 0.37 6.91 0.35 2.46e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg17042849 chr6:26104293 HIST1H4C -0.38 -5.65 -0.3 3.39e-8 Height; LUSC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.42 0.42 1.16e-15 Tonsillectomy; LUSC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg06618935 chr21:46677482 NA -0.37 -7.33 -0.37 1.75e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7771547 0.573 rs522179 chr6:36391605 G/A cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC cis rs6459804 1.000 rs73163880 chr7:157508755 C/T cg05731713 chr7:157510257 PTPRN2 0.49 9.51 0.46 3.77e-19 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg27535305 chr1:53392650 SCP2 0.47 9.26 0.45 2.59e-18 Monocyte count; LUSC trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg03929089 chr4:120376271 NA -0.5 -7.06 -0.36 9.63e-12 HDL cholesterol; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -8.49 -0.42 7.07e-16 Lymphocyte counts; LUSC cis rs597539 0.521 rs7943745 chr11:68605828 A/G cg21963583 chr11:68658836 MRPL21 -0.43 -7.02 -0.36 1.21e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12891047 1.000 rs4569184 chr14:68253298 C/G cg20999565 chr14:68265668 ZFYVE26 0.37 5.87 0.31 1.07e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9399135 0.967 rs6925424 chr6:135313948 T/A cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Red blood cell count; LUSC cis rs3749237 0.964 rs62260719 chr3:49852419 G/A cg03060546 chr3:49711283 APEH 0.56 7.63 0.39 2.43e-13 Resting heart rate; LUSC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg11764359 chr7:65958608 NA -0.68 -10.5 -0.5 1.84e-22 Aortic root size; LUSC cis rs4266144 0.562 rs56357317 chr3:156835174 T/A cg14969094 chr3:156848003 NA -0.36 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs9291683 0.595 rs10939665 chr4:10037628 T/C cg00071950 chr4:10020882 SLC2A9 0.65 10.85 0.51 1.11e-23 Bone mineral density; LUSC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7520050 0.807 rs5021934 chr1:46109304 A/G cg24296786 chr1:45957014 TESK2 0.44 6.19 0.32 1.72e-9 Red blood cell count;Reticulocyte count; LUSC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg12751644 chr20:60527061 NA -0.35 -6.27 -0.32 1.14e-9 Body mass index; LUSC cis rs3768617 0.510 rs2296291 chr1:183079509 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.84 0.51 1.15e-23 Fuchs's corneal dystrophy; LUSC cis rs7647973 0.925 rs6769821 chr3:49244657 G/A cg07636037 chr3:49044803 WDR6 0.67 8.12 0.41 9.08e-15 Menarche (age at onset); LUSC cis rs11785693 0.909 rs11784246 chr8:4970497 A/G cg26367366 chr8:4980734 NA 0.84 9.14 0.45 6.24e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15540553 chr11:64018643 PLCB3 -0.46 -6.14 -0.32 2.37e-9 Bipolar disorder and schizophrenia; LUSC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23524709 chr19:4636345 NA 0.44 7.45 0.38 8.14e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2282300 0.739 rs34044331 chr11:30264486 T/C cg25418670 chr11:30344373 C11orf46 -0.65 -9.32 -0.45 1.69e-18 Morning vs. evening chronotype; LUSC trans rs3134353 0.541 rs3134380 chr8:101943319 G/A cg20993868 chr7:22813445 NA 0.34 6.29 0.33 1.01e-9 Body mass index; LUSC cis rs1577917 1.000 rs12663651 chr6:86701655 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.45 -0.42 9.25e-16 Response to antipsychotic treatment; LUSC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.1 13.98 0.61 2.89e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg05535760 chr7:792225 HEATR2 -0.75 -7.55 -0.38 4.27e-13 Cerebrospinal P-tau181p levels; LUSC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg00944433 chr1:107599041 PRMT6 -0.35 -6.26 -0.32 1.16e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs6692729 0.966 rs1794035 chr1:227048758 T/C cg10327440 chr1:227177885 CDC42BPA 0.51 7.28 0.37 2.44e-12 Electrodermal activity; LUSC cis rs2840044 0.534 rs2124246 chr17:33885431 G/A cg05299278 chr17:33885742 SLFN14 0.35 7.91 0.4 3.8e-14 Response to radiotherapy in cancer (late toxicity); LUSC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg08677398 chr8:58056175 NA 0.52 6.24 0.32 1.34e-9 Developmental language disorder (linguistic errors); LUSC cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg08999081 chr20:33150536 PIGU -0.53 -10.53 -0.5 1.36e-22 Glomerular filtration rate (creatinine); LUSC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg04362960 chr10:104952993 NT5C2 0.59 9.38 0.46 1.04e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9359856 1.000 rs2094487 chr6:90314072 T/A cg13799429 chr6:90582589 CASP8AP2 0.57 6.75 0.35 6.5e-11 Bipolar disorder; LUSC trans rs57502260 0.704 rs923346 chr11:68182375 T/C cg00664054 chr8:21998309 REEP4 0.39 6.19 0.32 1.8e-9 Total body bone mineral density (age 45-60); LUSC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg09491104 chr22:46646882 C22orf40 -0.68 -6.37 -0.33 6.11e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg02038168 chr22:39784481 NA -0.49 -8.08 -0.4 1.22e-14 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg21361702 chr7:150065534 REPIN1 0.49 6.53 0.34 2.42e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7666738 0.546 rs17546687 chr4:98769266 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.15 0.45 5.87e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.03 15.77 0.65 2.97e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg00343986 chr7:65444356 GUSB 0.44 6.8 0.35 4.95e-11 Aortic root size; LUSC cis rs10504229 0.679 rs72649131 chr8:58054288 G/T cg22535103 chr8:58192502 C8orf71 -0.57 -6.54 -0.34 2.29e-10 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg16405210 chr4:1374714 KIAA1530 -0.53 -7.88 -0.4 4.77e-14 Obesity-related traits; LUSC cis rs6961069 0.716 rs11771152 chr7:80271327 T/C cg04458919 chr7:80252533 CD36 0.35 6.15 0.32 2.22e-9 Platelet count; LUSC cis rs11676348 0.808 rs12694430 chr2:219015799 T/C cg00012203 chr2:219082015 ARPC2 -0.56 -8.59 -0.43 3.31e-16 Ulcerative colitis; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg11843238 chr5:131593191 PDLIM4 0.36 6.67 0.34 1.05e-10 Blood metabolite levels; LUSC trans rs6502050 0.637 rs74765203 chr17:80118223 A/G cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.48e-10 Life satisfaction; LUSC cis rs765787 0.530 rs1706835 chr15:45517884 G/A cg24006582 chr15:45444508 DUOX1 -0.62 -9.12 -0.45 7.21e-18 Uric acid levels; LUSC cis rs2303282 0.933 rs11647104 chr16:56547254 C/T cg00500540 chr16:56394104 NA -0.44 -7.18 -0.37 4.68e-12 Breast cancer; LUSC cis rs9467773 0.967 rs1056347 chr6:26527524 G/C cg09904177 chr6:26538194 HMGN4 0.75 14.34 0.62 1.14e-36 Intelligence (multi-trait analysis); LUSC cis rs2074585 0.806 rs8033813 chr15:90999715 A/T cg22089800 chr15:90895588 ZNF774 0.62 9.36 0.46 1.22e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9660992 0.539 rs113699533 chr1:205122895 G/A cg21545522 chr1:205238299 TMCC2 0.46 8.69 0.43 1.66e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs13256369 0.802 rs35382339 chr8:8559255 G/A cg17143192 chr8:8559678 CLDN23 0.64 8.85 0.44 5.26e-17 Obesity-related traits; LUSC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg01579765 chr21:45077557 HSF2BP -0.55 -11.88 -0.55 2.17e-27 Mean corpuscular volume; LUSC cis rs367943 0.723 rs1965429 chr5:112679373 G/T cg12552261 chr5:112820674 MCC -0.38 -6.26 -0.32 1.16e-9 Type 2 diabetes; LUSC cis rs4409675 0.576 rs6564 chr1:28212975 A/G cg23691781 chr1:28212827 C1orf38 -0.31 -7.31 -0.37 1.97e-12 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21886851 chr18:47340405 SCARNA17;ACAA2 0.43 6.02 0.31 4.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg18305652 chr10:134549665 INPP5A 0.46 7.31 0.37 2.01e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.84 -0.39 6.1e-14 Blood metabolite levels; LUSC cis rs6424115 0.760 rs2999566 chr1:24051124 A/G cg10978503 chr1:24200527 CNR2 0.45 10.08 0.48 4.74e-21 Immature fraction of reticulocytes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08105378 chr19:19040175 HOMER3 0.39 6.0 0.31 5.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs17270561 0.779 rs12209218 chr6:25887776 C/A cg17691542 chr6:26056736 HIST1H1C 0.84 11.19 0.52 6.5e-25 Iron status biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04407520 chr19:3506228 FZR1 -0.44 -6.55 -0.34 2.22e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1728785 0.901 rs11075688 chr16:68655924 A/G cg02972257 chr16:68554789 NA 0.51 6.39 0.33 5.6e-10 Ulcerative colitis; LUSC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg13319975 chr6:146136371 FBXO30 -0.51 -7.63 -0.39 2.45e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7786808 0.712 rs12671981 chr7:158202971 G/A cg09998033 chr7:158218633 PTPRN2 -0.48 -7.58 -0.38 3.41e-13 Obesity-related traits; LUSC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC trans rs2262909 1.000 rs2017962 chr19:22208751 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -6.2 -0.32 1.68e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9303401 0.527 rs2116450 chr17:56745561 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.17 0.58 3.55e-32 Cognitive test performance; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg10729496 chr3:10149963 C3orf24 0.53 7.07 0.36 9.35e-12 Alzheimer's disease; LUSC trans rs16823866 0.847 rs77513726 chr2:145316727 A/T cg04212021 chr5:180231084 MGAT1 0.52 5.96 0.31 6.53e-9 White blood cell count (basophil); LUSC cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs10740039 1.000 rs10740040 chr10:62414743 G/A cg18175470 chr10:62150864 ANK3 -0.43 -6.78 -0.35 5.52e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11048434 0.736 rs7301381 chr12:9123932 T/C cg13575925 chr12:9217583 LOC144571 0.36 6.63 0.34 1.34e-10 Sjögren's syndrome; LUSC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg03517284 chr6:25882590 NA 0.37 6.11 0.32 2.85e-9 Intelligence (multi-trait analysis); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg15831613 chr1:212780972 ATF3 0.37 6.3 0.33 9.19e-10 Metabolite levels (Pyroglutamine); LUSC cis rs25645 0.502 rs9895948 chr17:38108363 T/C cg17467752 chr17:38218738 THRA 0.41 5.69 0.3 2.73e-8 Myeloid white cell count; LUSC cis rs6964587 0.869 rs6979024 chr7:91481512 T/C cg17063962 chr7:91808500 NA -0.51 -7.8 -0.39 8.02e-14 Breast cancer; LUSC cis rs2204008 0.606 rs6582502 chr12:38543352 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.41 -0.33 5.01e-10 Bladder cancer; LUSC cis rs2599510 0.840 rs466146 chr2:32539236 A/C cg02381751 chr2:32503542 YIPF4 0.38 5.68 0.3 2.87e-8 Interleukin-18 levels; LUSC cis rs2625529 0.730 rs2957725 chr15:72248205 C/A cg16672083 chr15:72433130 SENP8 0.5 8.07 0.4 1.32e-14 Red blood cell count; LUSC cis rs317865 0.737 rs73234629 chr4:16169776 G/A cg04764131 chr4:16228633 TAPT1;FLJ39653 0.6 5.64 0.3 3.55e-8 Kidney disease (early stage) in type 1 diabetes; LUSC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg15145296 chr3:125709740 NA -0.58 -6.5 -0.33 3e-10 Blood pressure (smoking interaction); LUSC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg09044154 chr16:88155775 NA -0.56 -7.43 -0.38 9.11e-13 Menopause (age at onset); LUSC cis rs6964587 0.610 rs6942852 chr7:91437883 A/C cg17063962 chr7:91808500 NA 0.52 8.3 0.41 2.67e-15 Breast cancer; LUSC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.35 -0.46 1.33e-18 Gut microbiome composition (summer); LUSC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg21285383 chr16:89894308 SPIRE2 0.32 6.77 0.35 5.69e-11 Vitiligo; LUSC cis rs7552167 1.000 rs7552167 chr1:24518643 A/G cg01960748 chr1:24522592 NA -0.64 -9.27 -0.45 2.3e-18 Psoriasis vulgaris; LUSC cis rs2835872 0.793 rs73220482 chr21:38986286 C/T cg20424643 chr21:39039972 KCNJ6 0.36 5.7 0.3 2.63e-8 Electroencephalographic traits in alcoholism; LUSC cis rs4268898 0.662 rs55661701 chr2:24400769 A/C cg06627628 chr2:24431161 ITSN2 -0.86 -12.07 -0.55 4.48e-28 Asthma; LUSC cis rs4843747 0.671 rs28465438 chr16:88103714 G/A cg09044154 chr16:88155775 NA -0.53 -6.93 -0.35 2.16e-11 Menopause (age at onset); LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg07677032 chr17:61819896 STRADA -0.52 -8.79 -0.43 8.27e-17 Prudent dietary pattern; LUSC cis rs6964587 1.000 rs1063243 chr7:91726927 A/C cg01689657 chr7:91764605 CYP51A1 0.31 5.65 0.3 3.48e-8 Breast cancer; LUSC cis rs9420 0.961 rs12805841 chr11:57443842 G/A cg23127183 chr11:57508653 C11orf31 -0.58 -9.06 -0.44 1.08e-17 Schizophrenia; LUSC cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg24130564 chr14:104152367 KLC1 -0.48 -7.14 -0.36 5.71e-12 Body mass index; LUSC cis rs12594515 1.000 rs35182335 chr15:45995184 C/G cg06207120 chr15:45996521 NA 0.39 5.86 0.31 1.11e-8 Waist circumference;Weight; LUSC cis rs561341 0.654 rs6505265 chr17:30172580 C/T cg00745463 chr17:30367425 LRRC37B 0.58 6.66 0.34 1.14e-10 Hip circumference adjusted for BMI; LUSC cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs9398803 0.687 rs9388507 chr6:126970895 G/T cg19875578 chr6:126661172 C6orf173 0.39 5.65 0.3 3.39e-8 Male-pattern baldness; LUSC cis rs9815354 0.680 rs73073292 chr3:42028023 C/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg26647111 chr11:31128758 NA 0.41 6.04 0.31 4.05e-9 Red blood cell count; LUSC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg06494592 chr3:125709126 NA -0.51 -6.24 -0.32 1.32e-9 Blood pressure (smoking interaction); LUSC cis rs6500602 0.826 rs11076830 chr16:4460049 A/G cg08645402 chr16:4508243 NA 0.48 7.23 0.37 3.34e-12 Schizophrenia; LUSC cis rs7804356 1.000 rs17375272 chr7:26866497 C/T cg03456212 chr7:26904342 SKAP2 -0.56 -6.44 -0.33 4.23e-10 Type 1 diabetes; LUSC cis rs8072100 0.837 rs8070463 chr17:45768836 A/G cg19784903 chr17:45786737 TBKBP1 -0.42 -6.73 -0.35 7.19e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11229555 0.645 rs56228632 chr11:58187444 A/G cg15696309 chr11:58395628 NA -0.64 -7.78 -0.39 9.19e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.15e-9 Mean platelet volume; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg12432903 chr7:1882776 MAD1L1 -0.51 -8.75 -0.43 1.08e-16 Bipolar disorder and schizophrenia; LUSC cis rs6496667 0.557 rs2589951 chr15:90958392 T/C cg10434728 chr15:90938212 IQGAP1 0.32 6.05 0.31 3.94e-9 Rheumatoid arthritis; LUSC cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.44 -0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs11122272 0.735 rs2749704 chr1:231526243 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.93 -0.48 1.61e-20 Hemoglobin concentration; LUSC cis rs3741151 1.000 rs7930880 chr11:73068769 A/C cg17517138 chr11:73019481 ARHGEF17 0.81 7.62 0.38 2.68e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.49 0.53 5.73e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.75 0.43 1.08e-16 Menopause (age at onset); LUSC cis rs7119 0.717 rs8033654 chr15:77825250 T/C cg27398640 chr15:77910606 LINGO1 -0.32 -6.68 -0.34 9.78e-11 Type 2 diabetes; LUSC cis rs10782582 0.609 rs78748984 chr1:76340467 G/A cg10523679 chr1:76189770 ACADM -0.47 -6.71 -0.34 8.21e-11 Daytime sleep phenotypes; LUSC cis rs12530845 0.673 rs73725437 chr7:135327853 G/A cg23117316 chr7:135346802 PL-5283 -0.62 -9.56 -0.46 2.64e-19 Red blood cell traits; LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs931127 0.658 rs4930305 chr11:65464000 A/G cg05805236 chr11:65401703 PCNXL3 0.41 6.94 0.35 2.11e-11 Systemic lupus erythematosus; LUSC cis rs9469578 1.000 rs16869456 chr6:33714622 G/A cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs7927592 0.913 rs12363722 chr11:68236291 A/C cg20283391 chr11:68216788 NA -0.61 -8.51 -0.42 5.91e-16 Total body bone mineral density; LUSC cis rs250677 0.687 rs250671 chr5:148446523 T/C cg18129178 chr5:148520854 ABLIM3 -0.69 -10.62 -0.5 6.72e-23 Breast cancer; LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.05 -15.82 -0.65 1.8e-42 Platelet count; LUSC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.49 0.38 6.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg19875535 chr5:140030758 IK -0.53 -8.78 -0.43 8.59e-17 Depressive symptoms (multi-trait analysis); LUSC trans rs710987 0.815 rs698147 chr5:3513485 A/G cg27629735 chr1:3556483 WDR8 -0.37 -6.13 -0.32 2.5e-9 Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis; LUSC cis rs8077889 0.869 rs11713 chr17:41845824 A/G cg26893861 chr17:41843967 DUSP3 -0.85 -12.51 -0.56 9.97e-30 Triglycerides; LUSC cis rs9660992 0.639 rs1151786 chr1:205227760 G/C cg21545522 chr1:205238299 TMCC2 0.52 9.66 0.47 1.28e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4566357 0.615 rs10178098 chr2:227914425 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -8.2 -0.41 5.4e-15 Coronary artery disease; LUSC cis rs2677744 0.719 rs1266492 chr15:91456102 T/C cg08740748 chr15:91446511 MAN2A2 -0.42 -5.73 -0.3 2.21e-8 Attention deficit hyperactivity disorder; LUSC trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg16797656 chr11:68205561 LRP5 0.36 6.01 0.31 4.74e-9 Total body bone mineral density; LUSC cis rs9398803 0.965 rs17754780 chr6:126664333 C/T cg19875578 chr6:126661172 C6orf173 0.41 6.11 0.32 2.71e-9 Male-pattern baldness; LUSC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg21433313 chr16:3507492 NAT15 0.79 9.84 0.47 3.14e-20 Tuberculosis; LUSC cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg08917208 chr2:24149416 ATAD2B 0.51 5.76 0.3 1.92e-8 Lymphocyte counts; LUSC trans rs7170930 0.618 rs7165111 chr15:66540873 T/C cg06396762 chr16:3202609 NA -0.72 -5.98 -0.31 5.75e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs9296092 0.538 rs9461881 chr6:33520041 C/T cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2046867 0.819 rs34132129 chr3:72829100 A/G cg25664220 chr3:72788482 NA -0.71 -12.16 -0.55 1.99e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6733011 0.508 rs12712041 chr2:99522059 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.01 -0.31 4.78e-9 Bipolar disorder; LUSC cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg02380750 chr20:61661411 NA 0.35 5.9 0.31 8.87e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6121246 0.657 rs74392247 chr20:30241737 C/T cg21427119 chr20:30132790 HM13 -0.5 -7.02 -0.36 1.25e-11 Mean corpuscular hemoglobin; LUSC cis rs250677 1.000 rs250676 chr5:148425518 A/T cg23229984 chr5:148520753 ABLIM3 0.37 6.13 0.32 2.55e-9 Breast cancer; LUSC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg24562669 chr7:97807699 LMTK2 0.34 5.95 0.31 6.83e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg12463550 chr7:65579703 CRCP 0.57 8.52 0.42 5.72e-16 Aortic root size; LUSC cis rs11048434 0.723 rs12820395 chr12:9137096 T/G cg23795048 chr12:9217529 LOC144571 0.34 5.91 0.31 8.5e-9 Sjögren's syndrome; LUSC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 3.03e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs804280 0.542 rs34117651 chr8:11791617 G/C cg06636001 chr8:8085503 FLJ10661 0.54 7.97 0.4 2.45e-14 Myopia (pathological); LUSC cis rs1113500 0.933 rs11185259 chr1:108635062 A/G cg11967332 chr1:108735228 SLC25A24 -0.42 -6.14 -0.32 2.33e-9 Growth-regulated protein alpha levels; LUSC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg00310523 chr12:86230176 RASSF9 -0.44 -8.28 -0.41 3.05e-15 Major depressive disorder; LUSC cis rs9532580 0.656 rs2721068 chr13:41139712 T/C cg21288729 chr13:41239152 FOXO1 0.58 7.95 0.4 2.93e-14 Mean corpuscular hemoglobin; LUSC cis rs7937682 0.924 rs489783 chr11:111520522 A/G cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg23711669 chr6:146136114 FBXO30 -0.83 -14.79 -0.63 1.93e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs500891 0.533 rs6901074 chr6:84173944 A/G cg08257003 chr6:84140564 ME1 0.33 8.01 0.4 1.87e-14 Platelet-derived growth factor BB levels; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg07092213 chr7:1199455 ZFAND2A -0.43 -6.55 -0.34 2.2e-10 Longevity;Endometriosis; LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg00814883 chr7:100076585 TSC22D4 -0.73 -9.8 -0.47 4.39e-20 Platelet count; LUSC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.62 0.34 1.45e-10 Lung cancer; LUSC cis rs1580019 0.844 rs1584615 chr7:32503258 G/C cg07520158 chr7:32535189 LSM5;AVL9 0.43 5.66 0.3 3.27e-8 Cognitive ability; LUSC cis rs11955175 1.000 rs45480797 chr5:40680964 C/G cg05478818 chr5:40835740 RPL37 0.71 5.73 0.3 2.24e-8 Bipolar disorder and schizophrenia; LUSC cis rs7215564 0.730 rs2171023 chr17:78608913 A/T cg09596252 chr17:78655493 RPTOR 0.54 6.03 0.31 4.3e-9 Myopia (pathological); LUSC cis rs7215564 0.908 rs2316063 chr17:78663360 G/A cg09596252 chr17:78655493 RPTOR 0.53 5.85 0.31 1.15e-8 Myopia (pathological); LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs6964587 1.000 rs34548928 chr7:91668365 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.44e-8 Breast cancer; LUSC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg03929089 chr4:120376271 NA -0.53 -7.42 -0.38 9.89e-13 HDL cholesterol; LUSC cis rs28374715 0.662 rs72737786 chr15:41500361 G/T cg18705301 chr15:41695430 NDUFAF1 -0.85 -15.05 -0.64 1.96e-39 Ulcerative colitis; LUSC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg00484396 chr16:3507460 NAT15 -0.42 -6.79 -0.35 5.25e-11 Body mass index (adult); LUSC cis rs868036 0.718 rs16951275 chr15:68077168 T/C cg27219399 chr15:67835830 MAP2K5 0.34 5.66 0.3 3.33e-8 Restless legs syndrome; LUSC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.39 -0.42 1.36e-15 Height; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg09177884 chr7:1199841 ZFAND2A -0.51 -6.98 -0.36 1.64e-11 Longevity;Endometriosis; LUSC cis rs6121246 0.909 rs7354225 chr20:30296881 C/T cg21427119 chr20:30132790 HM13 -0.39 -5.71 -0.3 2.45e-8 Mean corpuscular hemoglobin; LUSC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.76 -0.3 1.88e-8 Total body bone mineral density; LUSC cis rs7769051 1.000 rs58832890 chr6:133127139 C/T cg22852734 chr6:133119734 C6orf192 1.23 14.2 0.61 3.89e-36 Type 2 diabetes nephropathy; LUSC cis rs896543 0.702 rs12692189 chr2:237496112 A/G cg25295825 chr2:237489920 CXCR7 -0.52 -6.27 -0.32 1.12e-9 Alcohol dependence (age at onset); LUSC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.11 -0.32 2.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 5.88 0.31 1.01e-8 Personality dimensions; LUSC cis rs909341 0.818 rs2750483 chr20:62345470 A/G cg09650180 chr20:62225654 GMEB2 -0.44 -5.79 -0.3 1.62e-8 Atopic dermatitis; LUSC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg13683864 chr3:40499215 RPL14 1.03 16.65 0.67 9.6e-46 Renal cell carcinoma; LUSC cis rs78572108 0.858 rs4952570 chr2:42263259 G/A cg00607755 chr2:42274082 PKDCC 0.36 6.49 0.33 3.05e-10 Total body bone mineral density; LUSC cis rs9303280 0.901 rs2952140 chr17:37928059 C/T cg20243544 chr17:37824526 PNMT -0.41 -6.14 -0.32 2.38e-9 Self-reported allergy; LUSC cis rs11785400 0.793 rs4467920 chr8:143736846 C/T cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.47 -0.38 6.9e-13 Extrinsic epigenetic age acceleration; LUSC cis rs8016982 0.674 rs1951615 chr14:81671762 G/A cg01989461 chr14:81687754 GTF2A1 0.73 13.51 0.59 1.69e-33 Schizophrenia; LUSC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg02772935 chr3:125709198 NA -0.47 -5.66 -0.3 3.26e-8 Blood pressure (smoking interaction); LUSC cis rs4242434 0.672 rs11785031 chr8:22486612 A/G cg03733263 chr8:22462867 KIAA1967 0.77 12.42 0.56 2.29e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg11764359 chr7:65958608 NA -0.7 -10.7 -0.51 3.47e-23 Aortic root size; LUSC cis rs12928939 0.768 rs71386932 chr16:71816191 G/A cg03805757 chr16:71968109 PKD1L3 -0.46 -6.65 -0.34 1.23e-10 Post bronchodilator FEV1; LUSC cis rs6700896 0.931 rs1938497 chr1:66100450 G/A cg04111102 chr1:66153794 NA 0.32 7.08 0.36 8.57e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg05855489 chr10:104503620 C10orf26 0.58 9.28 0.45 2.17e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg01475377 chr6:109611718 NA -0.45 -8.27 -0.41 3.13e-15 Reticulocyte fraction of red cells; LUSC cis rs752010 0.871 rs10890149 chr1:42092791 T/A cg06885757 chr1:42089581 HIVEP3 0.45 8.79 0.43 7.99e-17 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs3960554 0.867 rs10239209 chr7:75804085 G/A cg17325771 chr7:75508891 RHBDD2 -0.42 -6.09 -0.32 3.17e-9 Eotaxin levels; LUSC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 6.25 0.32 1.25e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg11812906 chr14:75593930 NEK9 0.67 11.56 0.53 3.11e-26 Height; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.11 0.52 1.28e-24 Prudent dietary pattern; LUSC cis rs2070433 0.851 rs10854484 chr21:47926702 T/C cg12379764 chr21:47803548 PCNT 0.7 9.24 0.45 2.92e-18 Lymphocyte counts; LUSC cis rs4666002 0.917 rs2068834 chr2:27839539 A/G cg27432699 chr2:27873401 GPN1 0.39 5.67 0.3 3.1e-8 Phospholipid levels (plasma); LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 5.1e-14 Prudent dietary pattern; LUSC trans rs4332037 0.802 rs12113633 chr7:1932936 G/A cg10840412 chr1:235813424 GNG4 0.67 9.02 0.44 1.49e-17 Bipolar disorder; LUSC cis rs62400317 0.859 rs10948221 chr6:45236707 T/G cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs6964587 0.626 rs10266424 chr7:91503228 C/T cg17063962 chr7:91808500 NA -0.57 -9.23 -0.45 3.19e-18 Breast cancer; LUSC cis rs600626 0.636 rs10899109 chr11:75451201 G/A cg24262691 chr11:75473276 NA 0.48 6.38 0.33 6.06e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1691799 0.867 rs1168297 chr12:66735644 T/C cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.33e-31 White blood cell count (basophil); LUSC cis rs7577696 0.962 rs7581340 chr2:32337391 C/T cg02381751 chr2:32503542 YIPF4 -0.39 -5.66 -0.3 3.18e-8 Inflammatory biomarkers; LUSC cis rs1059312 0.522 rs3825181 chr12:129279264 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 0.6 8.4 0.42 1.26e-15 Systemic lupus erythematosus; LUSC cis rs7584330 0.737 rs7584314 chr2:238361089 C/T cg16989719 chr2:238392110 NA -0.41 -7.18 -0.37 4.43e-12 Prostate cancer; LUSC cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg21535247 chr6:8435926 SLC35B3 0.58 9.0 0.44 1.75e-17 Motion sickness; LUSC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs983392 0.836 rs7946992 chr11:59944810 T/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.86 -0.31 1.13e-8 Alzheimer's disease (late onset); LUSC cis rs7523050 0.643 rs12741359 chr1:109400489 T/C cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.39e-13 Bipolar disorder; LUSC cis rs7760949 0.889 rs9382688 chr6:13926746 A/T cg27413430 chr6:13925136 RNF182 0.6 8.64 0.43 2.39e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg27068330 chr11:65405492 SIPA1 0.55 6.52 0.34 2.55e-10 Blood pressure (age interaction); LUSC cis rs7772486 0.846 rs2892453 chr6:146377717 C/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.14 -0.36 5.74e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08971981 chr7:44163271 POLD2 -0.42 -6.23 -0.32 1.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg24531977 chr5:56204891 C5orf35 0.87 13.85 0.6 8.87e-35 Initial pursuit acceleration; LUSC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg04317338 chr11:64019027 PLCB3 0.66 7.51 0.38 5.28e-13 Mean platelet volume; LUSC trans rs911555 0.723 rs12894652 chr14:103926024 A/G cg17675199 chr6:35436792 RPL10A -0.43 -6.42 -0.33 4.61e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs240764 0.717 rs183566 chr6:101142605 A/T cg09795085 chr6:101329169 ASCC3 0.41 5.93 0.31 7.56e-9 Neuroticism; LUSC cis rs73200209 0.701 rs61939684 chr12:116509365 G/A cg01776926 chr12:116560359 MED13L -0.49 -6.03 -0.31 4.4e-9 Total body bone mineral density; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.59 -0.46 2.15e-19 Bipolar disorder and schizophrenia; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.04 -0.31 4.16e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9653442 0.675 rs12995420 chr2:100652578 T/C cg07810366 chr2:100720526 AFF3 -0.42 -6.98 -0.36 1.59e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs11864453 0.963 rs7185215 chr16:72034864 T/C cg01557791 chr16:72042693 DHODH -0.54 -7.92 -0.4 3.67e-14 Fibrinogen levels; LUSC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.85 -0.3 1.18e-8 Total body bone mineral density; LUSC cis rs9837602 0.938 rs9815439 chr3:99785206 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.2 0.32 1.67e-9 Breast cancer; LUSC cis rs8017423 0.967 rs2277516 chr14:90722824 G/C cg14092571 chr14:90743983 NA -0.36 -5.86 -0.31 1.11e-8 Mortality in heart failure; LUSC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.78 0.51 1.94e-23 Monocyte percentage of white cells; LUSC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg02534363 chr3:47050950 NBEAL2 0.35 5.72 0.3 2.36e-8 Colorectal cancer; LUSC trans rs61931739 0.517 rs10844830 chr12:34308133 C/T cg26384229 chr12:38710491 ALG10B 0.62 9.93 0.48 1.53e-20 Morning vs. evening chronotype; LUSC cis rs3820068 0.524 rs34094056 chr1:15824154 G/T cg17385448 chr1:15911702 AGMAT 0.38 6.06 0.31 3.59e-9 Systolic blood pressure; LUSC trans rs7786808 0.712 rs2335167 chr7:158213948 A/C cg02030672 chr11:45687055 CHST1 0.5 8.09 0.4 1.1e-14 Obesity-related traits; LUSC cis rs889512 0.642 rs8048529 chr16:75275630 C/T cg04987608 chr16:75300043 BCAR1 -0.5 -5.77 -0.3 1.84e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.8 -0.3 1.56e-8 Intelligence (multi-trait analysis); LUSC cis rs2324229 0.861 rs1180207 chr6:83954588 A/G cg08257003 chr6:84140564 ME1 0.26 6.03 0.31 4.38e-9 Platelet-derived growth factor BB levels; LUSC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.52 -0.34 2.6200000000000003e-10 Lung cancer; LUSC cis rs7818345 0.935 rs12542575 chr8:19286558 A/T cg11303988 chr8:19266685 CSGALNACT1 0.37 7.16 0.36 5.17e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2439831 1.000 rs2444029 chr15:43737484 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.84 0.44 5.72e-17 Lung cancer in ever smokers; LUSC cis rs10791097 0.690 rs12284487 chr11:130729705 T/C cg12179176 chr11:130786555 SNX19 0.74 12.12 0.55 2.8e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs1941687 0.797 rs9954214 chr18:31390754 T/C cg27147174 chr7:100797783 AP1S1 -0.45 -6.56 -0.34 2.04e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg11871910 chr12:69753446 YEATS4 0.83 14.65 0.63 7.16e-38 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22250642 chr22:38349509 C22orf23;POLR2F -0.42 -6.38 -0.33 6.03e-10 Electrocardiographic conduction measures; LUSC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg12963246 chr6:28129442 ZNF389 0.53 7.41 0.38 1.04e-12 Parkinson's disease; LUSC cis rs34779708 0.897 rs4934716 chr10:35369299 A/G cg03585969 chr10:35415529 CREM 0.59 8.74 0.43 1.16e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs921968 0.565 rs7586384 chr2:219582897 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.19 -0.49 2.02e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs9815354 0.812 rs55748698 chr3:41805233 G/A cg03022575 chr3:42003672 ULK4 0.83 8.52 0.42 5.39e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7202877 0.706 rs37599 chr16:75502132 C/T cg04384234 chr16:75411784 CFDP1 0.64 8.71 0.43 1.45e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg26384229 chr12:38710491 ALG10B 0.88 15.21 0.64 4.41e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs2392780 0.536 rs430693 chr8:128338594 G/T cg10195415 chr17:73887371 TRIM65 0.41 6.64 0.34 1.3100000000000001e-10 Breast cancer (early onset); LUSC cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg21535247 chr6:8435926 SLC35B3 0.58 9.0 0.44 1.75e-17 Motion sickness; LUSC cis rs9814567 1.000 rs9289478 chr3:134268619 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.25 -0.59 1.75e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg13902645 chr11:5959945 NA -0.57 -7.89 -0.4 4.46e-14 DNA methylation (variation); LUSC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 14.45 0.62 4.24e-37 Platelet count; LUSC cis rs116988415 0.584 rs74859785 chr14:65249684 C/T cg00114569 chr14:65239327 SPTB 0.64 6.94 0.35 2.1e-11 Daytime sleep phenotypes; LUSC cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg17366294 chr4:99064904 C4orf37 0.52 9.14 0.45 6.41e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.632 rs6009782 chr22:50010812 C/G cg05373962 chr22:49881684 NA -0.41 -8.64 -0.43 2.4e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs477692 0.905 rs514963 chr10:131419707 C/T cg11019008 chr10:131425282 MGMT 0.37 5.73 0.3 2.25e-8 Response to temozolomide; LUSC cis rs7927592 0.913 rs10047412 chr11:68232912 T/C cg01657329 chr11:68192670 LRP5 -0.41 -5.82 -0.3 1.39e-8 Total body bone mineral density; LUSC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg04369109 chr6:150039330 LATS1 -0.53 -7.62 -0.38 2.68e-13 Lung cancer; LUSC trans rs9650657 0.740 rs2277130 chr8:10677601 G/C cg15556689 chr8:8085844 FLJ10661 -0.44 -6.59 -0.34 1.75e-10 Neuroticism; LUSC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg15073853 chr19:18549131 ISYNA1 -0.32 -5.7 -0.3 2.6e-8 Breast cancer; LUSC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs459571 1.000 rs456207 chr9:136911140 G/A cg13789015 chr9:136890014 NCRNA00094 0.67 12.31 0.56 5.87e-29 Platelet distribution width; LUSC cis rs2279817 0.863 rs12749985 chr1:18026004 C/T cg21791023 chr1:18019539 ARHGEF10L -0.44 -6.59 -0.34 1.68e-10 Neuroticism; LUSC cis rs17401966 0.838 rs946502 chr1:10309279 G/C cg19773385 chr1:10388646 KIF1B -0.51 -8.86 -0.44 4.99e-17 Hepatocellular carcinoma; LUSC cis rs67311347 0.577 rs2371129 chr3:40248393 C/T cg02782426 chr3:40428986 ENTPD3 -0.3 -6.0 -0.31 5.23e-9 Renal cell carcinoma; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg06873352 chr17:61820015 STRADA 0.7 12.67 0.57 2.52e-30 Prudent dietary pattern; LUSC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg06027949 chr8:82754900 SNX16 0.43 5.73 0.3 2.22e-8 Diastolic blood pressure; LUSC trans rs9662633 1.000 rs7517037 chr1:3647877 T/C cg06237983 chr7:27187269 HOXA6 -0.66 -6.13 -0.32 2.52e-9 Visceral adipose tissue adjusted for BMI; LUSC cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg03146154 chr1:46216737 IPP -0.54 -8.3 -0.41 2.66e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4891159 0.790 rs8087557 chr18:74116848 G/C cg24786174 chr18:74118243 ZNF516 -0.87 -16.73 -0.68 4.4e-46 Longevity; LUSC cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg23711669 chr6:146136114 FBXO30 -0.83 -14.85 -0.63 1.13e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9788721 0.630 rs77681598 chr15:78906103 C/A cg06917634 chr15:78832804 PSMA4 -0.7 -12.0 -0.55 8.21e-28 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6500395 0.963 rs6500404 chr16:48690083 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs7618501 0.665 rs7621352 chr3:50070763 A/C cg21659725 chr3:3221576 CRBN -0.65 -10.87 -0.51 8.98e-24 Intelligence (multi-trait analysis); LUSC cis rs7575217 0.654 rs62155196 chr2:101701022 A/G cg23907051 chr2:101730305 TBC1D8 0.29 7.72 0.39 1.34e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs2386661 0.516 rs61832676 chr10:5646337 G/A cg17085576 chr10:5658249 NA -0.43 -6.25 -0.32 1.26e-9 Breast cancer; LUSC cis rs3857536 0.785 rs1935895 chr6:66936606 T/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs7614311 0.552 rs73117078 chr3:63942084 G/A cg22134162 chr3:63841271 THOC7 -0.47 -5.94 -0.31 7e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs13418410 0.539 rs1545399 chr2:33843801 A/G cg04131969 chr2:33951647 MYADML -0.75 -10.98 -0.52 3.68e-24 Non-response to antidepressants and depression; LUSC trans rs1493916 1.000 rs4393645 chr18:31394407 C/T cg13755796 chr4:20253514 NA -0.43 -6.59 -0.34 1.69e-10 Life satisfaction; LUSC cis rs11785400 0.793 rs6996760 chr8:143722386 G/A cg24634471 chr8:143751801 JRK 0.5 7.09 0.36 8.08e-12 Schizophrenia; LUSC cis rs12497850 0.863 rs4858799 chr3:48728204 G/A cg00383909 chr3:49044727 WDR6 1.17 10.42 0.5 3.3e-22 Parkinson's disease; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg06221963 chr1:154839813 KCNN3 -0.65 -15.85 -0.66 1.38e-42 Prostate cancer; LUSC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg06544989 chr22:39130855 UNC84B 0.35 5.83 0.3 1.28e-8 Menopause (age at onset); LUSC cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg21535247 chr6:8435926 SLC35B3 0.59 9.2 0.45 4.02e-18 Motion sickness; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg24503407 chr1:205819492 PM20D1 0.56 9.27 0.45 2.31e-18 Menarche (age at onset); LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg16145915 chr7:1198662 ZFAND2A -0.69 -13.82 -0.6 1.12e-34 Longevity;Endometriosis; LUSC cis rs62400317 0.731 rs72867436 chr6:44975488 T/G cg18551225 chr6:44695536 NA -0.43 -6.89 -0.35 2.83e-11 Total body bone mineral density; LUSC cis rs559928 0.597 rs2186572 chr11:63895887 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 7.27 0.37 2.53e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7560272 0.723 rs4852927 chr2:73641557 C/T cg20560298 chr2:73613845 ALMS1 0.46 7.1 0.36 7.76e-12 Schizophrenia; LUSC cis rs12190007 0.547 rs2981945 chr6:169819839 G/A ch.6.169577133F chr6:169835210 NA -0.39 -5.83 -0.3 1.32e-8 Obesity-related traits; LUSC cis rs3126085 0.935 rs12738889 chr1:152257688 G/A cg26876637 chr1:152193138 HRNR -0.45 -6.08 -0.32 3.31e-9 Atopic dermatitis; LUSC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg27284194 chr4:1044797 NA 0.6 7.99 0.4 2.28e-14 Recombination rate (females); LUSC cis rs7264396 0.832 rs224416 chr20:34138406 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -6.5 -0.34 2.85e-10 Total cholesterol levels; LUSC cis rs11098499 0.863 rs11736416 chr4:120431661 C/T cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.72e-25 Corneal astigmatism; LUSC cis rs4919687 0.550 rs7904252 chr10:104456725 A/C cg04362960 chr10:104952993 NT5C2 -0.41 -6.02 -0.31 4.55e-9 Colorectal cancer; LUSC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg03161606 chr19:29218774 NA 0.62 8.83 0.44 6.02e-17 Methadone dose in opioid dependence; LUSC cis rs453301 0.522 rs2929455 chr8:9083433 A/T cg08975724 chr8:8085496 FLJ10661 -0.4 -5.76 -0.3 1.86e-8 Joint mobility (Beighton score); LUSC cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg02423579 chr7:2872169 GNA12 -0.43 -6.47 -0.33 3.51e-10 Height; LUSC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg06636001 chr8:8085503 FLJ10661 0.61 9.39 0.46 9.43e-19 Mood instability; LUSC cis rs7927592 0.913 rs11228292 chr11:68379772 C/T cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.58e-9 Total body bone mineral density; LUSC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg09796270 chr17:17721594 SREBF1 0.4 6.92 0.35 2.33e-11 Total body bone mineral density; LUSC cis rs7582720 1.000 rs72932573 chr2:203861113 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 8.37 0.42 1.63e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg03806693 chr22:41940476 POLR3H 0.88 12.29 0.56 7.03e-29 Vitiligo; LUSC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg04025307 chr7:1156635 C7orf50 0.44 5.93 0.31 7.47e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2282300 0.739 rs1222216 chr11:30346052 C/T cg25418670 chr11:30344373 C11orf46 -0.64 -9.18 -0.45 4.63e-18 Morning vs. evening chronotype; LUSC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg26587870 chr6:27730563 NA -0.67 -6.23 -0.32 1.42e-9 Depression; LUSC cis rs9790314 1.000 rs336593 chr3:161076431 T/C cg04691961 chr3:161091175 C3orf57 -0.36 -6.24 -0.32 1.34e-9 Morning vs. evening chronotype; LUSC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.55 -0.34 2.2e-10 Alzheimer's disease (late onset); LUSC cis rs12997796 0.556 rs7558827 chr2:86923178 A/G cg25203885 chr2:87302643 LOC285074 -0.75 -8.13 -0.41 8.47e-15 Schizophrenia; LUSC trans rs10432489 0.708 rs11687566 chr2:181744418 T/C cg25678491 chr13:101327172 TMTC4 -0.86 -6.32 -0.33 8.58e-10 QT interval; LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg25767906 chr1:53392781 SCP2 -0.63 -12.69 -0.57 2.14e-30 Monocyte count; LUSC cis rs12760731 0.565 rs7541122 chr1:178199214 G/C cg00404053 chr1:178313656 RASAL2 0.66 6.86 0.35 3.32e-11 Obesity-related traits; LUSC cis rs9486719 0.895 rs12527021 chr6:97025496 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.98 -0.48 1.1e-20 Migraine;Coronary artery disease; LUSC cis rs72781680 0.898 rs12612492 chr2:24093756 C/T cg20701182 chr2:24300061 SF3B14 0.7 7.52 0.38 5.12e-13 Lymphocyte counts; LUSC cis rs7927771 0.524 rs3816605 chr11:47857253 T/C cg20307385 chr11:47447363 PSMC3 0.44 6.36 0.33 6.67e-10 Subjective well-being; LUSC cis rs3770081 1.000 rs1036554 chr2:86236099 G/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.78 -5.68 -0.3 3e-8 Facial emotion recognition (sad faces); LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg02353165 chr6:42928485 GNMT 0.68 11.84 0.54 3.07e-27 Plasma homocysteine levels (post-methionine load test); LUSC cis rs478304 0.651 rs948493 chr11:65552154 C/T cg17480646 chr11:65405466 SIPA1 -0.46 -5.94 -0.31 7.01e-9 Acne (severe); LUSC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg20573242 chr4:122745356 CCNA2 0.44 6.77 0.35 5.65e-11 Type 2 diabetes; LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.58 0.67 1.84e-45 Platelet count; LUSC cis rs11674184 0.659 rs11679605 chr2:11722468 G/A cg07314298 chr2:11723111 GREB1 -0.71 -11.45 -0.53 8.14e-26 Endometriosis; LUSC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg12365402 chr11:9010492 NRIP3 0.48 8.75 0.43 1.11e-16 Hemoglobin concentration; LUSC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg13298116 chr11:62369859 EML3;MTA2 0.6 9.66 0.47 1.23e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs12579753 1.000 rs10862368 chr12:82244514 C/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs34779708 0.966 rs17591163 chr10:35465279 G/C cg04310649 chr10:35416472 CREM -0.42 -6.43 -0.33 4.33e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9308433 0.505 rs6695148 chr1:214497861 G/T cg06198575 chr1:214491504 SMYD2 0.45 6.99 0.36 1.53e-11 IgG glycosylation; LUSC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg08564027 chr20:61660810 NA 0.9 17.32 0.69 2.14e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08704250 chr15:31115839 NA -0.46 -6.84 -0.35 3.89e-11 Huntington's disease progression; LUSC cis rs6981523 0.553 rs11783890 chr8:11056388 T/C cg21775007 chr8:11205619 TDH -0.48 -6.16 -0.32 2.12e-9 Neuroticism; LUSC cis rs34779708 0.966 rs4294520 chr10:35422506 C/T cg03585969 chr10:35415529 CREM 0.6 8.76 0.43 9.64e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -5.98 -0.31 5.85e-9 Major depressive disorder; LUSC cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg06484146 chr7:12443880 VWDE -0.62 -6.23 -0.32 1.37e-9 Coronary artery disease; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg16606324 chr3:10149918 C3orf24 -0.63 -7.89 -0.4 4.49e-14 Alzheimer's disease; LUSC cis rs2262909 0.962 rs409439 chr19:22227432 C/T cg11619707 chr19:22235551 ZNF257 -0.38 -5.7 -0.3 2.7e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.8 0.3 1.53e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9341835 0.709 rs9359467 chr6:64154975 G/C cg03326410 chr6:64151739 NA -0.37 -5.98 -0.31 5.76e-9 Schizophrenia; LUSC trans rs1459104 0.641 rs4454742 chr11:54840592 A/T cg15704280 chr7:45808275 SEPT13 0.77 6.69 0.34 9.3e-11 Body mass index; LUSC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg15839431 chr19:19639596 YJEFN3 -0.42 -5.74 -0.3 2.17e-8 Tonsillectomy; LUSC cis rs6840360 0.530 rs6839802 chr4:152485834 G/A cg22705602 chr4:152727874 NA -0.34 -6.86 -0.35 3.31e-11 Intelligence (multi-trait analysis); LUSC cis rs75920871 0.545 rs7939934 chr11:116861268 A/T cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.76 -0.35 6.12e-11 Subjective well-being; LUSC cis rs6977660 0.714 rs6970798 chr7:19816741 G/C cg07541023 chr7:19748670 TWISTNB 0.63 6.84 0.35 3.87e-11 Thyroid stimulating hormone; LUSC cis rs7843479 0.965 rs733543 chr8:21835465 A/G cg17168535 chr8:21777572 XPO7 0.67 10.29 0.49 9.63e-22 Mean corpuscular volume; LUSC cis rs2625529 0.668 rs12914070 chr15:72334279 T/C cg16672083 chr15:72433130 SENP8 -0.51 -7.51 -0.38 5.41e-13 Red blood cell count; LUSC cis rs12973672 1.000 rs28365136 chr19:35769561 T/G cg12095397 chr19:35769544 USF2 0.44 6.91 0.35 2.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg15691649 chr6:25882328 NA -0.41 -5.95 -0.31 6.71e-9 Intelligence (multi-trait analysis); LUSC cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.56 -8.75 -0.43 1.11e-16 Personality dimensions; LUSC cis rs12464559 0.522 rs6715027 chr2:152626657 T/C cg01189475 chr2:152685088 ARL5A 0.62 6.7 0.34 8.8e-11 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg26597838 chr10:835615 NA 0.98 14.03 0.61 1.75e-35 Eosinophil percentage of granulocytes; LUSC trans rs11039798 0.588 rs6485891 chr11:48612024 T/A cg03929089 chr4:120376271 NA 0.6 6.35 0.33 7.17e-10 Axial length; LUSC cis rs748404 0.578 rs4547312 chr15:43632138 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.43 5.99 0.31 5.34e-9 Lung cancer; LUSC cis rs782590 0.967 rs11125581 chr2:55796527 C/G cg18811423 chr2:55921094 PNPT1 0.83 14.48 0.62 3.21e-37 Metabolic syndrome; LUSC cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg16339924 chr4:17578868 LAP3 0.68 10.99 0.52 3.57e-24 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2882667 0.522 rs7731574 chr5:138454192 A/G cg04439458 chr5:138467593 SIL1 0.37 7.73 0.39 1.28e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.46 0.38 7.35e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg25173405 chr17:45401733 C17orf57 0.36 5.76 0.3 1.95e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12956009 0.518 rs11663852 chr18:44887542 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.42 0.33 4.66e-10 Educational attainment (years of education); LUSC cis rs208520 1.000 rs208529 chr6:66957549 T/C cg07460842 chr6:66804631 NA -0.95 -12.41 -0.56 2.52e-29 Exhaled nitric oxide output; LUSC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg08859206 chr1:53392774 SCP2 -0.42 -6.78 -0.35 5.41e-11 Monocyte count; LUSC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.49 0.33 3.09e-10 Menarche (age at onset); LUSC cis rs7582180 0.606 rs4851299 chr2:100954191 C/A cg14675211 chr2:100938903 LONRF2 0.37 5.74 0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs4268898 0.529 rs4426488 chr2:24372815 A/G cg06627628 chr2:24431161 ITSN2 0.51 7.27 0.37 2.53e-12 Asthma; LUSC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg16049864 chr8:95962084 TP53INP1 -0.62 -11.6 -0.54 2.2e-26 Type 2 diabetes; LUSC cis rs2153904 0.793 rs12132270 chr1:205660940 C/T cg23034840 chr1:205782522 SLC41A1 -0.65 -6.73 -0.35 7.2e-11 Prostate-specific antigen levels; LUSC cis rs782590 0.935 rs2627779 chr2:55892356 A/G cg18811423 chr2:55921094 PNPT1 0.88 15.31 0.64 1.87e-40 Metabolic syndrome; LUSC cis rs10751667 0.643 rs10794343 chr11:925493 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.41e-10 Alzheimer's disease (late onset); LUSC cis rs9733 0.540 rs4971041 chr1:150537357 C/T cg17724175 chr1:150552817 MCL1 -0.33 -5.67 -0.3 3.16e-8 Tonsillectomy; LUSC cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.87 -0.35 3.17e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7267979 0.933 rs11699203 chr20:25435169 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs983392 0.792 rs595481 chr11:59914267 T/C cg24026212 chr11:59952134 MS4A6A -0.31 -5.67 -0.3 3.14e-8 Alzheimer's disease (late onset); LUSC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg19812747 chr11:111475976 SIK2 -0.57 -8.23 -0.41 4.18e-15 Primary sclerosing cholangitis; LUSC cis rs73198271 0.562 rs17154743 chr8:8650787 A/G cg01851573 chr8:8652454 MFHAS1 0.64 9.11 0.45 7.52e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg03351412 chr1:154909251 PMVK 0.52 8.04 0.4 1.53e-14 Prostate cancer; LUSC cis rs3617 0.503 rs9866243 chr3:52915219 C/T cg18099408 chr3:52552593 STAB1 0.36 5.97 0.31 6.15e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg20503657 chr10:835505 NA 0.96 13.18 0.58 3.15e-32 Eosinophil percentage of granulocytes; LUSC cis rs34779708 0.966 rs12775759 chr10:35400183 G/T cg03585969 chr10:35415529 CREM 0.62 8.97 0.44 2.2e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2979489 0.891 rs2979498 chr8:30375251 T/A cg26383811 chr8:30366931 RBPMS -0.53 -8.18 -0.41 6.08e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs7336332 0.628 rs9581855 chr13:28018014 G/A cg22138327 chr13:27999177 GTF3A 0.77 9.83 0.47 3.36e-20 Weight; LUSC cis rs13256369 0.802 rs11995449 chr8:8559898 G/A cg17143192 chr8:8559678 CLDN23 0.65 8.96 0.44 2.31e-17 Obesity-related traits; LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg07092213 chr7:1199455 ZFAND2A -0.56 -9.02 -0.44 1.49e-17 Longevity;Endometriosis; LUSC cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg24812749 chr6:127587940 RNF146 0.92 13.69 0.6 3.62e-34 Breast cancer; LUSC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg24060327 chr5:131705240 SLC22A5 -0.39 -6.31 -0.33 9e-10 Blood metabolite levels; LUSC cis rs7917772 0.560 rs7912339 chr10:104373758 G/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.59 -0.38 3.28e-13 Personality dimensions; LUSC cis rs68170813 0.652 rs75136686 chr7:107180949 G/A cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs12122100 0.651 rs6665411 chr1:146547095 A/G cg03526459 chr1:146549940 NA 0.42 6.97 0.36 1.7e-11 HIV-1 control; LUSC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg14552801 chr7:65878734 NA -0.43 -5.89 -0.31 9.49e-9 Aortic root size; LUSC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg24531977 chr5:56204891 C5orf35 -1.1 -16.16 -0.66 8.62e-44 Initial pursuit acceleration; LUSC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg07414643 chr4:187882934 NA 0.55 10.53 0.5 1.41e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg04369109 chr6:150039330 LATS1 -0.51 -7.46 -0.38 7.73e-13 Lung cancer; LUSC cis rs6964587 0.839 rs6950538 chr7:91417816 T/C cg17063962 chr7:91808500 NA 0.58 8.8 0.43 7.52e-17 Breast cancer; LUSC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.58 0.34 1.81e-10 Glioblastoma; LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.5 0.62 2.71e-37 Platelet count; LUSC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg26314531 chr2:26401878 FAM59B -0.69 -9.37 -0.46 1.12e-18 Gut microbiome composition (summer); LUSC trans rs6502050 0.835 rs11658335 chr17:80084821 C/T cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg07636037 chr3:49044803 WDR6 1.05 18.49 0.71 4.64e-53 Parkinson's disease; LUSC cis rs2224391 1.000 rs2224391 chr6:5260936 A/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.5 -7.24 -0.37 3.15e-12 Height; LUSC cis rs9581857 0.547 rs9581876 chr13:28101113 T/C cg22138327 chr13:27999177 GTF3A 0.69 6.98 0.36 1.6e-11 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg07716408 chr11:68623521 NA -0.3 -5.82 -0.3 1.39e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9660992 0.674 rs17345837 chr1:205263122 C/T cg21643547 chr1:205240462 TMCC2 -0.51 -9.93 -0.48 1.55e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.77 12.56 0.57 6.58e-30 Menarche (age at onset); LUSC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg06637938 chr14:75390232 RPS6KL1 0.54 8.65 0.43 2.27e-16 Height; LUSC cis rs722599 0.715 rs8008785 chr14:75307600 G/A cg08847533 chr14:75593920 NEK9 -0.44 -6.26 -0.32 1.2e-9 IgG glycosylation; LUSC cis rs73195822 0.614 rs17793540 chr12:111215575 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.04 0.36 1.13e-11 Itch intensity from mosquito bite; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03776541 chr10:99400533 PI4K2A -0.46 -6.8 -0.35 4.89e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2587949 0.615 rs2600115 chr3:4225026 G/T cg15139668 chr4:4577005 NA -0.42 -6.22 -0.32 1.51e-9 Periodontitis (DPAL); LUSC trans rs11098499 0.821 rs10032151 chr4:120391628 C/T cg25214090 chr10:38739885 LOC399744 0.58 8.47 0.42 8.08e-16 Corneal astigmatism; LUSC trans rs72674100 1.000 rs28457587 chr4:97991521 T/C cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs8072100 0.782 rs62074054 chr17:45771816 T/C cg03886242 chr7:26192032 NFE2L3 -0.41 -6.25 -0.32 1.28e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12519773 1.000 rs959922 chr5:92450649 C/T cg18783429 chr5:92414398 NA -0.3 -6.73 -0.35 7.41e-11 Migraine; LUSC cis rs34375054 0.525 rs12316499 chr12:125593318 G/A cg09839279 chr12:125627357 AACS -0.36 -6.5 -0.34 2.87e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9303401 0.659 rs35103007 chr17:56900738 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.29 0.59 1.23e-32 Cognitive test performance; LUSC trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1577917 0.740 rs9344533 chr6:86236188 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 9.17 0.45 5.15e-18 Response to antipsychotic treatment; LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg16362232 chr11:430036 ANO9 0.62 8.09 0.4 1.08e-14 Body mass index; LUSC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg23791538 chr6:167370224 RNASET2 0.43 6.93 0.35 2.11e-11 Crohn's disease; LUSC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg20476274 chr7:133979776 SLC35B4 0.85 16.05 0.66 2.18e-43 Mean platelet volume; LUSC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg26597838 chr10:835615 NA 1.21 16.6 0.67 1.46e-45 Eosinophil percentage of granulocytes; LUSC cis rs4363385 0.818 rs946095 chr1:153006470 T/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.44e-12 Inflammatory skin disease; LUSC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg22823121 chr1:150693482 HORMAD1 -0.45 -6.7 -0.34 8.88e-11 Tonsillectomy; LUSC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.36 0.37 1.48e-12 Crohn's disease; LUSC cis rs10464366 0.843 rs12701691 chr7:39090177 T/G cg15212455 chr7:39170539 POU6F2 0.41 6.21 0.32 1.56e-9 IgG glycosylation; LUSC cis rs62400317 0.762 rs62436376 chr6:44885817 C/T cg20913747 chr6:44695427 NA -0.48 -7.51 -0.38 5.55e-13 Total body bone mineral density; LUSC cis rs17685 0.712 rs10235086 chr7:75833138 G/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.49 -0.38 6.17e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10751667 0.600 rs1128419 chr11:1010750 G/A ch.11.42038R chr11:967971 AP2A2 0.46 6.56 0.34 2.05e-10 Alzheimer's disease (late onset); LUSC cis rs6543140 1.000 rs6543140 chr2:103074274 G/T cg09003973 chr2:102972529 NA 0.54 7.02 0.36 1.25e-11 Blood protein levels; LUSC cis rs477692 0.699 rs471390 chr10:131382825 A/G cg05714579 chr10:131428358 MGMT -0.46 -6.68 -0.34 9.94e-11 Response to temozolomide; LUSC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs6430585 0.527 rs2304366 chr2:136467119 C/T cg07169764 chr2:136633963 MCM6 1.05 13.73 0.6 2.45e-34 Corneal structure; LUSC cis rs6542838 0.588 rs4851175 chr2:99530118 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.99 -0.31 5.41e-9 Fear of minor pain; LUSC trans rs12682352 0.579 rs7006589 chr8:8668486 A/G cg21775007 chr8:11205619 TDH 0.44 6.0 0.31 5.07e-9 Neuroticism; LUSC cis rs12464483 0.591 rs67686878 chr2:30895044 C/T cg12454169 chr2:30669597 LCLAT1 0.71 8.83 0.43 6.06e-17 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg27535305 chr1:53392650 SCP2 -0.4 -7.49 -0.38 6.15e-13 Monocyte count; LUSC cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg18404041 chr3:52824283 ITIH1 0.58 9.38 0.46 1.06e-18 Schizophrenia; LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC trans rs9329221 0.662 rs34155841 chr8:10247529 T/G cg08975724 chr8:8085496 FLJ10661 0.45 5.98 0.31 5.87e-9 Neuroticism; LUSC cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.91 0.31 8.5e-9 Rheumatoid arthritis; LUSC cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.44 0.56 1.86e-29 Motion sickness; LUSC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg22508957 chr16:3507546 NAT15 0.63 10.29 0.49 9.04e-22 Tuberculosis; LUSC trans rs2018683 0.707 rs1021689 chr7:28974223 G/T cg19402173 chr7:128379420 CALU -0.47 -7.24 -0.37 3.06e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.43 -0.42 1.03e-15 Breast cancer; LUSC trans rs4332037 0.575 rs55952733 chr7:2070680 G/A cg10840412 chr1:235813424 GNG4 0.54 7.09 0.36 8.24e-12 Bipolar disorder; LUSC cis rs9486715 0.964 rs6921480 chr6:97066329 C/G cg06623918 chr6:96969491 KIAA0776 -0.85 -14.16 -0.61 5.78e-36 Headache; LUSC cis rs6964587 0.839 rs9656002 chr7:91475007 A/G cg22709100 chr7:91322751 NA -0.47 -6.87 -0.35 3.19e-11 Breast cancer; LUSC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg25258033 chr6:167368657 RNASET2 -0.45 -7.26 -0.37 2.76e-12 Crohn's disease; LUSC cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.05 -0.44 1.19e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7267979 1.000 rs6107045 chr20:25441936 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.22 0.71 5.32e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1005224 0.963 rs12887886 chr14:76167846 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.62 -8.58 -0.42 3.62e-16 Large artery stroke; LUSC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs735860 0.726 rs209510 chr6:53202035 T/C cg10236188 chr6:53219634 NA 0.38 5.66 0.3 3.3e-8 Glaucoma; LUSC cis rs8078723 0.714 rs9915252 chr17:38145088 C/G cg17467752 chr17:38218738 THRA -0.71 -11.39 -0.53 1.31e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg22823121 chr1:150693482 HORMAD1 0.51 7.44 0.38 8.56e-13 Melanoma; LUSC cis rs6500602 0.563 rs917304 chr16:4440426 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 6.9 0.35 2.62e-11 Schizophrenia; LUSC cis rs11792861 0.926 rs59904140 chr9:111910051 C/T cg13535736 chr9:111863775 C9orf5 -0.42 -6.85 -0.35 3.64e-11 Menarche (age at onset); LUSC trans rs7980799 0.649 rs2389215 chr12:33649457 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.92 -0.4 3.67e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg13206674 chr6:150067644 NUP43 0.56 8.38 0.42 1.47e-15 Lung cancer; LUSC cis rs600231 0.708 rs602838 chr11:65253247 T/G cg21890820 chr11:65308645 LTBP3 0.49 7.28 0.37 2.37e-12 Bone mineral density; LUSC cis rs6840360 0.571 rs11931934 chr4:152552082 A/G cg22705602 chr4:152727874 NA -0.3 -6.11 -0.32 2.83e-9 Intelligence (multi-trait analysis); LUSC cis rs11030122 0.702 rs2898947 chr11:3977572 G/A cg18678763 chr11:4115507 RRM1 -0.46 -6.02 -0.31 4.53e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -7.81 -0.39 7.68e-14 Chronic sinus infection; LUSC cis rs1298908 1.000 rs1298908 chr10:82013134 A/G cg01528321 chr10:82214614 TSPAN14 -0.52 -7.7 -0.39 1.5700000000000001e-13 Diabetic kidney disease; LUSC cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs13315871 0.929 rs71311853 chr3:58319152 C/T cg20936604 chr3:58311152 NA -0.76 -7.25 -0.37 2.83e-12 Cholesterol, total; LUSC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg21665744 chr7:39171113 POU6F2 0.48 7.63 0.39 2.56e-13 IgG glycosylation; LUSC cis rs10979 1.000 rs13198159 chr6:143891953 C/T cg25407410 chr6:143891975 LOC285740 -0.74 -11.93 -0.55 1.41e-27 Hypospadias; LUSC cis rs12760731 0.720 rs12022185 chr1:178279653 A/G cg00404053 chr1:178313656 RASAL2 0.64 6.73 0.35 7.36e-11 Obesity-related traits; LUSC cis rs854765 0.693 rs9907287 chr17:17774118 C/T cg16928487 chr17:17741425 SREBF1 0.45 8.84 0.44 5.67e-17 Total body bone mineral density; LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg27170947 chr2:26402098 FAM59B -0.66 -9.79 -0.47 4.59e-20 Gut microbiome composition (summer); LUSC cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg13010199 chr12:38710504 ALG10B -0.58 -9.11 -0.45 8.04e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.33 0.45 1.46e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7772486 0.806 rs4075695 chr6:146250959 A/G cg23711669 chr6:146136114 FBXO30 -0.81 -14.85 -0.63 1.16e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg16339924 chr4:17578868 LAP3 0.54 8.26 0.41 3.44e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg13628971 chr7:2884303 GNA12 0.49 6.98 0.36 1.62e-11 Height; LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg22638593 chr5:131593259 PDLIM4 0.42 6.12 0.32 2.64e-9 Breast cancer; LUSC cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.85 -0.35 3.67e-11 Menopause (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01103590 chr12:71833534 LGR5 0.66 6.08 0.32 3.22e-9 Cognitive performance; LUSC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.98 0.31 5.84e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg06873352 chr17:61820015 STRADA 0.54 8.29 0.41 2.74e-15 Height; LUSC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg26314531 chr2:26401878 FAM59B -0.7 -9.43 -0.46 7.21e-19 Gut microbiome composition (summer); LUSC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg16339924 chr4:17578868 LAP3 0.5 7.57 0.38 3.57e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 0.87 11.91 0.55 1.73e-27 Platelet count; LUSC cis rs911555 0.755 rs2756135 chr14:103962579 G/A cg12935359 chr14:103987150 CKB 0.66 10.79 0.51 1.68e-23 Intelligence (multi-trait analysis); LUSC cis rs3740540 0.530 rs2362506 chr10:126290751 C/G cg04949429 chr10:126290192 LHPP 0.36 7.64 0.39 2.29e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs7824557 0.564 rs2572389 chr8:11236392 T/C cg21775007 chr8:11205619 TDH -0.65 -10.36 -0.49 5.25e-22 Retinal vascular caliber; LUSC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg00745463 chr17:30367425 LRRC37B -0.74 -9.03 -0.44 1.41e-17 Hip circumference adjusted for BMI; LUSC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg11764359 chr7:65958608 NA 0.7 11.5 0.53 5.14e-26 Aortic root size; LUSC cis rs2130392 1.000 rs873686 chr4:185638876 A/G cg04058563 chr4:185651563 MLF1IP -0.44 -7.47 -0.38 6.91e-13 Kawasaki disease; LUSC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.39 5.74 0.3 2.13e-8 Schizophrenia; LUSC cis rs9796 0.745 rs2947493 chr15:41375694 G/A cg18705301 chr15:41695430 NDUFAF1 -0.47 -8.27 -0.41 3.13e-15 Menopause (age at onset); LUSC cis rs67478160 0.654 rs4906365 chr14:104229230 G/C cg01849466 chr14:104193079 ZFYVE21 -0.57 -8.99 -0.44 1.81e-17 Schizophrenia; LUSC cis rs1775715 0.870 rs1755084 chr10:32253709 C/T cg18675610 chr10:32216311 ARHGAP12 0.29 6.03 0.31 4.39e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1003719 0.751 rs56268364 chr21:38542765 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs977987 0.586 rs12920883 chr16:75432681 T/C cg03315344 chr16:75512273 CHST6 0.48 8.93 0.44 2.98e-17 Dupuytren's disease; LUSC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.47 0.53 6.9e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg08200582 chr11:442649 ANO9 -0.56 -5.96 -0.31 6.34e-9 Body mass index; LUSC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg27286337 chr10:134555280 INPP5A -0.83 -11.06 -0.52 2.02e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg25554036 chr4:6271136 WFS1 0.56 11.5 0.53 5.38e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg15790184 chr11:494944 RNH1 0.59 6.34 0.33 7.35e-10 Body mass index; LUSC cis rs8040855 0.599 rs6496791 chr15:85725659 C/T cg04831495 chr15:85060580 GOLGA6L5 0.42 6.97 0.36 1.72e-11 Bulimia nervosa; LUSC cis rs61931739 0.534 rs7965503 chr12:34199349 A/G cg06521331 chr12:34319734 NA -0.46 -7.6 -0.38 2.95e-13 Morning vs. evening chronotype; LUSC cis rs1691799 0.867 rs1168316 chr12:66746239 A/G cg16791601 chr12:66731901 HELB -0.71 -12.52 -0.57 9.7e-30 White blood cell count (basophil); LUSC cis rs11155671 0.530 rs7757984 chr6:150208651 A/G cg07701084 chr6:150067640 NUP43 0.47 6.93 0.35 2.16e-11 Testicular germ cell tumor; LUSC cis rs62244186 0.566 rs2135531 chr3:44881158 C/G cg16615211 chr3:44902933 MIR564;TMEM42 0.35 5.91 0.31 8.66e-9 Depressive symptoms; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg23034840 chr1:205782522 SLC41A1 0.67 9.97 0.48 1.17e-20 Menarche (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00030291 chr7:8302094 ICA1 -0.48 -6.12 -0.32 2.64e-9 Bipolar disorder and schizophrenia; LUSC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08704250 chr15:31115839 NA -0.47 -7.07 -0.36 9.16e-12 Huntington's disease progression; LUSC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg14440974 chr22:39074834 NA -0.36 -6.16 -0.32 2.08e-9 Menopause (age at onset); LUSC cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs4953318 0.894 rs10495928 chr2:46353166 A/G cg12428440 chr2:46370979 PRKCE 0.37 6.6 0.34 1.66e-10 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg22166914 chr1:53195759 ZYG11B 0.6 9.8 0.47 4.26e-20 Monocyte count; LUSC cis rs1371867 0.846 rs1613453 chr8:101244215 G/T cg06636551 chr8:101224915 SPAG1 0.43 7.89 0.4 4.26e-14 Atrioventricular conduction; LUSC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.98 -0.31 5.72e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.909 rs28581362 chr4:120283548 T/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg01097406 chr16:89675127 NA 0.38 7.92 0.4 3.68e-14 Vitiligo; LUSC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg21028142 chr17:79581711 NPLOC4 0.33 8.03 0.4 1.7e-14 Eye color traits; LUSC cis rs12291225 0.679 rs11023178 chr11:14310282 G/A cg05501817 chr11:14380813 RRAS2 -0.56 -8.85 -0.44 5.34e-17 Sense of smell; LUSC cis rs9467773 1.000 rs4871 chr6:26545632 G/A cg11502198 chr6:26597334 ABT1 0.59 9.37 0.46 1.16e-18 Intelligence (multi-trait analysis); LUSC cis rs2762353 0.935 rs1165196 chr6:25813150 A/G cg15691649 chr6:25882328 NA 0.35 5.65 0.3 3.42e-8 Blood metabolite levels; LUSC cis rs8072100 0.666 rs6503804 chr17:45772447 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.4 -6.2 -0.32 1.64e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10986311 0.862 rs10818950 chr9:127130137 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.38 -6.0 -0.31 5e-9 Vitiligo; LUSC cis rs7712401 0.601 rs2910140 chr5:122264395 T/A cg19077854 chr5:122220652 SNX24 0.41 8.93 0.44 2.84e-17 Mean platelet volume; LUSC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg21724239 chr8:58056113 NA 0.58 7.17 0.37 4.74e-12 Developmental language disorder (linguistic errors); LUSC cis rs751728 1.000 rs11752297 chr6:33735154 G/C cg25922239 chr6:33757077 LEMD2 0.52 7.68 0.39 1.83e-13 Crohn's disease; LUSC cis rs1448094 0.967 rs10779222 chr12:86330775 G/A cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.31e-9 Major depressive disorder; LUSC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg00701064 chr4:6280414 WFS1 0.59 14.24 0.61 2.82e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg00999904 chr2:3704751 ALLC -0.43 -6.79 -0.35 5.02e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg02475777 chr4:1388615 CRIPAK 0.38 5.83 0.3 1.29e-8 Obesity-related traits; LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg05025164 chr4:1340916 KIAA1530 -0.63 -10.0 -0.48 8.78e-21 Obesity-related traits; LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 6.53 0.34 2.48e-10 Bipolar disorder; LUSC trans rs2164273 0.565 rs2736387 chr8:11157371 A/C cg15556689 chr8:8085844 FLJ10661 0.43 6.39 0.33 5.59e-10 Extraversion; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22080282 chr18:72920932 ZADH2 -0.47 -6.31 -0.33 8.91e-10 Hepatitis; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.03 -0.4 1.71e-14 Lymphocyte counts; LUSC cis rs7727544 0.582 rs2301579 chr5:131553340 C/A cg14196790 chr5:131705035 SLC22A5 0.43 7.18 0.37 4.66e-12 Blood metabolite levels; LUSC cis rs3764563 0.799 rs7249233 chr19:15723591 T/C cg20725493 chr19:15740067 CYP4F8 -0.66 -6.99 -0.36 1.5e-11 Inflammatory biomarkers; LUSC cis rs72772090 0.539 rs17481856 chr5:96116808 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -6.61 -0.34 1.53e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6951245 0.572 rs74791540 chr7:1061913 C/A cg24642844 chr7:1081250 C7orf50 -0.68 -6.41 -0.33 5.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7909074 0.966 rs879074 chr10:45400053 G/A cg05187965 chr10:45406764 TMEM72 -0.36 -8.42 -0.42 1.11e-15 Mean corpuscular volume; LUSC cis rs77106637 0.929 rs1059000 chr11:72504972 G/C cg03713592 chr11:72463424 ARAP1 0.82 9.55 0.46 2.89e-19 Type 2 diabetes; LUSC cis rs12478296 0.786 rs6721704 chr2:242994923 A/G cg06360820 chr2:242988706 NA -0.85 -10.17 -0.49 2.47e-21 Obesity-related traits; LUSC cis rs2607426 0.681 rs10420651 chr19:41235038 C/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.92 6.83 0.35 3.91e-11 Blood protein levels; LUSC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg02951883 chr7:2050386 MAD1L1 -0.51 -9.15 -0.45 5.71e-18 Schizophrenia; LUSC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.44 -7.32 -0.37 1.92e-12 IgG glycosylation; LUSC cis rs11190604 1.000 rs11190602 chr10:102297256 T/C cg23241863 chr10:102295624 HIF1AN 0.48 5.91 0.31 8.26e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs644799 0.544 rs1727165 chr11:95521648 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.67 9.83 0.47 3.46e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11098499 0.599 rs3864142 chr4:120266191 A/T cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.4e-19 Corneal astigmatism; LUSC cis rs7903847 0.642 rs11189183 chr10:99144321 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.3 -0.37 2.19e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs10140922 0.931 rs4982261 chr14:35822159 C/T cg07166546 chr14:35805898 NA -0.24 -5.86 -0.31 1.12e-8 Hip circumference adjusted for BMI; LUSC cis rs1111571 0.576 rs1465469 chr16:68397916 T/G cg02226672 chr16:68398533 SMPD3 0.31 5.65 0.3 3.52e-8 Glomerular filtration rate (creatinine); LUSC cis rs11190604 1.000 rs2298074 chr10:102247526 G/C cg16342193 chr10:102329863 NA -0.37 -6.49 -0.33 3.04e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9911578 1.000 rs12938772 chr17:56776320 T/C cg05425664 chr17:57184151 TRIM37 -0.53 -7.96 -0.4 2.77e-14 Intelligence (multi-trait analysis); LUSC cis rs6977660 0.714 rs6959039 chr7:19818182 T/C cg05791153 chr7:19748676 TWISTNB 0.66 7.0 0.36 1.38e-11 Thyroid stimulating hormone; LUSC cis rs9902453 1.000 rs9897206 chr17:28406108 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.98 -0.44 2.08e-17 Coffee consumption (cups per day); LUSC cis rs3741151 0.773 rs7931767 chr11:73239207 A/G cg17517138 chr11:73019481 ARHGEF17 0.96 8.06 0.4 1.35e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg13298116 chr11:62369859 EML3;MTA2 0.57 9.44 0.46 6.61e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg20891558 chr2:74357851 NA 0.79 14.23 0.61 3.02e-36 Gestational age at birth (maternal effect); LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg16405210 chr4:1374714 KIAA1530 -0.52 -7.67 -0.39 1.92e-13 Obesity-related traits; LUSC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg06238570 chr21:40685208 BRWD1 -0.58 -9.24 -0.45 3.03e-18 Menarche (age at onset); LUSC trans rs7637701 0.713 rs9867857 chr3:156491160 C/T cg11006288 chr14:69012387 RAD51L1 0.39 6.23 0.32 1.37e-9 Breast cancer; LUSC cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -5.97 -0.31 5.96e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.623 rs7010753 chr8:8373956 A/G cg06636001 chr8:8085503 FLJ10661 0.62 9.9 0.48 2.01e-20 Mood instability; LUSC cis rs34638657 0.732 rs61111557 chr16:82201102 A/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.33 -0.33 7.89e-10 Lung adenocarcinoma; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg00149659 chr3:10157352 C3orf10 0.94 12.49 0.56 1.18e-29 Alzheimer's disease; LUSC cis rs10740039 0.768 rs7895268 chr10:62463237 T/C cg18175470 chr10:62150864 ANK3 -0.43 -6.58 -0.34 1.77e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9300255 0.770 rs12299125 chr12:123862447 C/T cg00376283 chr12:123451042 ABCB9 -0.67 -7.77 -0.39 9.99e-14 Neutrophil percentage of white cells; LUSC cis rs8060686 0.516 rs4640173 chr16:68163602 C/A cg05110241 chr16:68378359 PRMT7 -0.5 -6.35 -0.33 7.05e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs3812762 0.917 rs10743087 chr11:8786058 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.4 7.09 0.36 8.09e-12 Hypospadias; LUSC cis rs679087 0.659 rs302318 chr12:29921667 T/C cg14258853 chr12:29935411 TMTC1 -0.72 -10.69 -0.5 4.02e-23 Schizophrenia; LUSC cis rs3768617 0.528 rs4652778 chr1:183097420 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 10.95 0.51 4.95e-24 Fuchs's corneal dystrophy; LUSC cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.07 0.36 8.93e-12 Rheumatoid arthritis; LUSC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.75 0.35 6.46e-11 Tonsillectomy; LUSC cis rs9399135 0.967 rs6908512 chr6:135367757 A/G cg22676075 chr6:135203613 NA 0.47 7.27 0.37 2.62e-12 Red blood cell count; LUSC trans rs9388451 0.839 rs3799709 chr6:126078361 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.61 -9.73 -0.47 7.05e-20 Brugada syndrome; LUSC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.84 0.75 2.15e-62 Homoarginine levels; LUSC cis rs1662342 1.000 rs1791106 chr18:3251862 G/A cg00760847 chr18:3262519 MYL12B -0.58 -5.68 -0.3 2.97e-8 QRS duration; LUSC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg05623727 chr3:50126028 RBM5 0.32 6.07 0.32 3.52e-9 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg26727032 chr16:67993705 SLC12A4 -0.42 -6.24 -0.32 1.3e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6681460 1.000 rs6656912 chr1:67083671 A/G cg02459107 chr1:67143332 SGIP1 0.43 7.48 0.38 6.78e-13 Presence of antiphospholipid antibodies; LUSC cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.91 -0.35 2.4e-11 Menopause (age at onset); LUSC cis rs7824557 0.547 rs2736287 chr8:11228006 G/A cg21775007 chr8:11205619 TDH -0.75 -12.42 -0.56 2.23e-29 Retinal vascular caliber; LUSC trans rs11933661 0.528 rs1022008 chr4:130966269 C/G cg23838308 chr17:57785056 PTRH2;TMEM49 0.4 6.15 0.32 2.16e-9 Alcohol dependence; LUSC cis rs7927592 0.913 rs4084149 chr11:68288567 A/G cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.13e-9 Total body bone mineral density; LUSC cis rs34638657 0.702 rs62044259 chr16:82199523 A/T cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.55e-10 Lung adenocarcinoma; LUSC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg03929089 chr4:120376271 NA 0.91 14.19 0.61 4.36e-36 Coronary artery disease; LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg16031515 chr1:205743344 RAB7L1 -0.27 -5.69 -0.3 2.83e-8 Menarche (age at onset); LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg25767906 chr1:53392781 SCP2 0.48 8.66 0.43 1.98e-16 Monocyte count; LUSC cis rs3806843 1.000 rs11167609 chr5:140200426 T/G cg26395211 chr5:140044315 WDR55 -0.37 -5.7 -0.3 2.69e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9905704 0.874 rs28483505 chr17:56844109 G/C cg12560992 chr17:57184187 TRIM37 0.55 7.84 0.39 6.19e-14 Testicular germ cell tumor; LUSC cis rs7223966 0.960 rs2319990 chr17:61705397 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.17 0.37 4.94e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7954584 0.611 rs3887885 chr12:122336486 C/T cg21016266 chr12:122356598 WDR66 0.58 8.79 0.43 8.29e-17 Mean corpuscular volume; LUSC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg17718321 chr1:152188247 HRNR -0.37 -6.71 -0.34 8.31e-11 Inflammatory skin disease; LUSC cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg14584255 chr6:163149320 PACRG;PARK2 -0.34 -6.47 -0.33 3.42e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2404602 0.692 rs34272342 chr15:77012276 A/C cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.81e-12 Blood metabolite levels; LUSC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg20283391 chr11:68216788 NA -0.55 -8.19 -0.41 5.61e-15 Total body bone mineral density; LUSC cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.84 -0.35 3.88e-11 Menopause (age at onset); LUSC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg17376030 chr22:41985996 PMM1 -0.47 -5.89 -0.31 9.6e-9 Vitiligo; LUSC cis rs41298997 1 rs41298997 chr1:206655331 C/T cg11166312 chr1:206654246 IKBKE 0.62 9.26 0.45 2.59e-18 Psoriasis; LUSC trans rs2262909 1.000 rs436039 chr19:22214873 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -6.2 -0.32 1.68e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs4794106 0.792 rs847682 chr17:48208274 C/T cg13127421 chr17:48202128 SAMD14 -0.56 -9.36 -0.46 1.22e-18 Temporomandibular joint disorder; LUSC cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.41 0.33 5.02e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg02018176 chr4:1364513 KIAA1530 0.74 13.19 0.59 2.85e-32 Longevity; LUSC trans rs72674100 0.737 rs28461925 chr4:97991609 G/T cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg22800045 chr5:56110881 MAP3K1 0.77 10.07 0.48 5.15e-21 Initial pursuit acceleration; LUSC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg08859206 chr1:53392774 SCP2 0.46 7.75 0.39 1.13e-13 Monocyte count; LUSC cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg13256891 chr4:100009986 ADH5 0.52 7.09 0.36 8.03e-12 Smoking initiation; LUSC cis rs644148 0.836 rs2686775 chr19:45000059 C/T cg15540054 chr19:45004280 ZNF180 -0.63 -9.32 -0.45 1.6e-18 Personality dimensions; LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.94 0.51 5.08e-24 Menopause (age at onset); LUSC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg27170947 chr2:26402098 FAM59B -0.62 -9.41 -0.46 8.39e-19 Gut microbiome composition (summer); LUSC cis rs9300255 0.602 rs1569068 chr12:123632276 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.36 6.53 0.34 2.5e-10 Neutrophil percentage of white cells; LUSC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg22823121 chr1:150693482 HORMAD1 0.46 6.58 0.34 1.82e-10 Melanoma; LUSC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.3e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.38 6.11 0.32 2.85e-9 Self-reported allergy; LUSC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.74 -0.39 1.18e-13 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg27089754 chr16:75590036 TMEM231 0.79 6.14 0.32 2.37e-9 Cognitive performance; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11690462 0.528 rs6710942 chr2:26636390 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.48 6.23 0.32 1.41e-9 Coronary artery disease; LUSC cis rs662064 0.748 rs2506896 chr1:10603716 T/C cg20482658 chr1:10539492 PEX14 0.29 5.81 0.3 1.44e-8 Asthma; LUSC cis rs5167 0.566 rs2075620 chr19:45480037 C/T cg13119609 chr19:45449297 APOC2 -0.35 -5.98 -0.31 5.66e-9 Blood protein levels; LUSC cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.37 0.42 1.64e-15 Colorectal cancer; LUSC cis rs9815354 0.812 rs12186050 chr3:41836879 G/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9462027 0.527 rs11755393 chr6:34824636 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.83 -0.3 1.31e-8 Systemic lupus erythematosus; LUSC cis rs1215050 0.791 rs165241 chr4:98681112 C/T cg05340658 chr4:99064831 C4orf37 0.46 7.28 0.37 2.39e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9527 0.590 rs3740386 chr10:104931051 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.41 -0.33 4.97e-10 Arsenic metabolism; LUSC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg19920283 chr7:105172520 RINT1 0.59 6.21 0.32 1.56e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4356932 0.691 rs6532078 chr4:76920809 A/G cg00809888 chr4:76862425 NAAA 0.36 5.74 0.3 2.13e-8 Blood protein levels; LUSC cis rs7043114 0.525 rs2274966 chr9:95155563 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.89 -0.35 2.77e-11 Height; LUSC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.05e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs877282 0.898 rs11253356 chr10:768604 G/A cg17470449 chr10:769945 NA 0.47 6.63 0.34 1.34e-10 Uric acid levels; LUSC trans rs7824557 0.628 rs58283816 chr8:11192551 G/C cg08975724 chr8:8085496 FLJ10661 0.42 6.1 0.32 2.99e-9 Retinal vascular caliber; LUSC cis rs9650315 0.789 rs36126100 chr8:57188731 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.41 0.33 4.87e-10 Height; LUSC trans rs1728785 0.591 rs10775305 chr16:68656460 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.74 0.39 1.17e-13 Ulcerative colitis; LUSC cis rs3857536 0.706 rs1418854 chr6:66893284 C/T cg07460842 chr6:66804631 NA -0.48 -6.71 -0.34 8.12e-11 Blood trace element (Cu levels); LUSC cis rs601339 1.000 rs525215 chr12:123179771 G/A cg11919336 chr12:123188078 GPR109A 0.43 6.52 0.34 2.64e-10 Adiponectin levels; LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg06600287 chr1:53387719 ECHDC2 0.29 6.14 0.32 2.29e-9 Monocyte count; LUSC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11644478 chr21:40555479 PSMG1 0.63 10.23 0.49 1.46e-21 Cognitive function; LUSC cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.34 -5.66 -0.3 3.24e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7851660 0.809 rs10984235 chr9:100660896 C/T cg13688889 chr9:100608707 NA -0.54 -8.44 -0.42 9.53e-16 Strep throat; LUSC cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg16230307 chr14:35515116 FAM177A1 0.54 7.23 0.37 3.26e-12 Psoriasis; LUSC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08109568 chr15:31115862 NA -0.58 -8.17 -0.41 6.41e-15 Huntington's disease progression; LUSC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.23 0.41 4.25e-15 Tonsillectomy; LUSC cis rs7568458 0.684 rs3731828 chr2:85806266 C/T cg17127132 chr2:85788382 GGCX 0.43 6.07 0.32 3.46e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7586879 0.796 rs36071142 chr2:25080570 C/T cg01884057 chr2:25150051 NA 0.38 7.92 0.4 3.57e-14 Body mass index; LUSC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6754311 0.731 rs892715 chr2:136576577 T/C cg07169764 chr2:136633963 MCM6 -0.58 -7.55 -0.38 4.27e-13 Mosquito bite size; LUSC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg01420254 chr6:26195488 NA -0.68 -7.28 -0.37 2.35e-12 Gout;Renal underexcretion gout; LUSC trans rs7937682 0.883 rs1611989 chr11:111456299 A/G cg18187862 chr3:45730750 SACM1L 0.53 6.9 0.35 2.6e-11 Primary sclerosing cholangitis; LUSC cis rs870825 0.616 rs7659101 chr4:185632158 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.44 0.59 3.34e-33 Blood protein levels; LUSC cis rs11155671 0.530 rs4869763 chr6:150211684 T/C cg13206674 chr6:150067644 NUP43 0.43 6.54 0.34 2.28e-10 Testicular germ cell tumor; LUSC cis rs7296418 0.922 rs1727293 chr12:123648032 C/T cg05973401 chr12:123451056 ABCB9 0.6 8.62 0.43 2.66e-16 Platelet count; LUSC cis rs7973719 1.000 rs1839622 chr12:7334534 G/C cg07052231 chr12:7363540 PEX5 0.51 8.79 0.43 8.07e-17 IgG glycosylation; LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg11062466 chr8:58055876 NA 0.73 8.62 0.43 2.79e-16 Developmental language disorder (linguistic errors); LUSC cis rs6733011 0.508 rs4850889 chr2:99521385 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.01 -0.31 4.78e-9 Bipolar disorder; LUSC cis rs28655083 1.000 rs11864710 chr16:77075284 A/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.39 -6.13 -0.32 2.43e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9527 0.590 rs7898770 chr10:104756636 A/G cg05855489 chr10:104503620 C10orf26 -0.53 -8.02 -0.4 1.8e-14 Arsenic metabolism; LUSC cis rs644799 0.562 rs515546 chr11:95588756 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.6 8.79 0.43 8.07e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.89 -0.55 1.97e-27 Type 2 diabetes; LUSC cis rs7428 1.000 rs72840063 chr2:85550396 T/A cg24342717 chr2:85555507 TGOLN2 -0.61 -8.93 -0.44 2.98e-17 Ear protrusion; LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.84e-30 Prudent dietary pattern; LUSC cis rs2742234 0.541 rs11238483 chr10:43728780 A/G cg15436174 chr10:43711423 RASGEF1A 0.44 7.08 0.36 8.82e-12 Hirschsprung disease; LUSC cis rs3540 0.533 rs7495080 chr15:91056681 G/A cg22089800 chr15:90895588 ZNF774 -0.66 -10.06 -0.48 5.77e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg18252515 chr7:66147081 NA -0.58 -7.98 -0.4 2.31e-14 Corneal structure; LUSC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.49 -0.73 4.84e-57 Height; LUSC cis rs9815354 0.680 rs73075231 chr3:42051694 T/C cg03022575 chr3:42003672 ULK4 0.78 7.85 0.39 5.64e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs10746514 0.833 rs867844 chr1:232266278 A/T cg09506761 chr1:232265262 NA 0.56 9.73 0.47 7.5599999999999994e-20 Response to statin therapy; LUSC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg03806693 chr22:41940476 POLR3H 1.01 14.5 0.62 2.65e-37 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9815354 0.812 rs73071343 chr3:41826877 G/C cg03022575 chr3:42003672 ULK4 0.85 8.62 0.43 2.78e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg11366901 chr6:160182831 ACAT2 0.92 13.3 0.59 1.06e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg06387496 chr7:2775674 GNA12 -0.36 -5.69 -0.3 2.83e-8 Height; LUSC cis rs1991651 0.507 rs17778581 chr8:10743421 C/T cg27411982 chr8:10470053 RP1L1 -0.43 -6.29 -0.33 9.92e-10 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; LUSC cis rs7267979 1.000 rs2482928 chr20:25331530 A/G cg03522245 chr20:25566470 NINL -0.35 -5.69 -0.3 2.85e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg27494647 chr7:150038898 RARRES2 0.51 7.86 0.4 5.3e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs3862030 0.720 rs11595149 chr10:104235978 C/T cg22532475 chr10:104410764 TRIM8 0.24 5.7 0.3 2.59e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs61931739 0.612 rs1906137 chr12:33939676 T/A cg26384229 chr12:38710491 ALG10B 0.51 7.63 0.39 2.43e-13 Morning vs. evening chronotype; LUSC cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg23711669 chr6:146136114 FBXO30 0.89 16.33 0.67 1.72e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg14530993 chr4:882597 GAK 0.73 7.39 0.37 1.22e-12 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.37 0.56 3.55e-29 Cognitive test performance; LUSC cis rs7107174 1.000 rs10793309 chr11:78093799 G/A cg02023728 chr11:77925099 USP35 0.47 7.0 0.36 1.42e-11 Testicular germ cell tumor; LUSC cis rs9653442 0.527 rs13003982 chr2:100759078 T/C cg07810366 chr2:100720526 AFF3 -0.44 -7.56 -0.38 4.02e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg02380750 chr20:61661411 NA 0.34 5.93 0.31 7.57e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1595825 0.891 rs60129872 chr2:198653192 A/G cg00982548 chr2:198649783 BOLL -0.59 -7.3 -0.37 2.19e-12 Ulcerative colitis; LUSC cis rs4566357 0.615 rs2272204 chr2:227915601 G/T cg11843606 chr2:227700838 RHBDD1 -0.53 -8.11 -0.41 9.41e-15 Coronary artery disease; LUSC cis rs8060686 0.516 rs7194894 chr16:68145062 C/T cg04539111 chr16:67997858 SLC12A4 -0.42 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs10876993 0.855 rs1678520 chr12:58049319 C/G cg15848620 chr12:58087721 OS9 -0.53 -7.62 -0.39 2.58e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg05347473 chr6:146136440 FBXO30 0.55 9.73 0.47 7.59e-20 Lobe attachment (rater-scored or self-reported); LUSC trans rs4714291 0.925 rs847747 chr6:40080069 G/T cg02267698 chr19:7991119 CTXN1 0.55 7.91 0.4 3.69e-14 Strep throat; LUSC cis rs453301 0.653 rs11784393 chr8:8903134 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.6 0.34 1.64e-10 Joint mobility (Beighton score); LUSC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg13072238 chr3:49761600 GMPPB -0.65 -8.46 -0.42 8.31e-16 Menarche (age at onset); LUSC cis rs3737883 1.000 rs10753933 chr1:203026214 T/G cg00805880 chr1:203045044 PPFIA4 -0.3 -5.99 -0.31 5.58e-9 Early onset atrial fibrillation; LUSC cis rs4792901 0.659 rs8073121 chr17:41542922 A/C cg22562494 chr17:41607896 ETV4 -0.33 -6.21 -0.32 1.56e-9 Dupuytren's disease; LUSC cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg21280719 chr6:42927975 GNMT 0.3 6.07 0.32 3.54e-9 Blood protein levels; LUSC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg08888203 chr3:10149979 C3orf24 0.45 6.79 0.35 5.25e-11 Alzheimer's disease; LUSC cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.93 -0.4 3.26e-14 Chronic sinus infection; LUSC cis rs6594499 0.872 rs10043631 chr5:110443228 C/T cg04022379 chr5:110408740 TSLP 0.44 6.68 0.34 1.01e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs11039798 1.000 rs7479655 chr11:48576714 G/T cg15704280 chr7:45808275 SEPT13 0.69 6.51 0.34 2.81e-10 Axial length; LUSC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs34421088 0.560 rs2248316 chr8:11397073 A/C cg21775007 chr8:11205619 TDH -0.53 -7.96 -0.4 2.72e-14 Neuroticism; LUSC cis rs3862030 0.720 rs3740415 chr10:104232716 G/A cg05855489 chr10:104503620 C10orf26 0.49 7.36 0.37 1.46e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs2797160 1.000 rs926853 chr6:126021435 A/T cg05039488 chr6:79577232 IRAK1BP1 0.46 7.0 0.36 1.37e-11 Endometrial cancer; LUSC cis rs12681287 0.547 rs56752411 chr8:87515156 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.35 -0.37 1.52e-12 Caudate activity during reward; LUSC cis rs8014204 0.935 rs8010840 chr14:75355203 T/C cg08847533 chr14:75593920 NEK9 -0.39 -5.68 -0.3 2.92e-8 Caffeine consumption; LUSC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg08219700 chr8:58056026 NA 0.5 6.4 0.33 5.22e-10 Developmental language disorder (linguistic errors); LUSC cis rs240768 1.000 rs77642814 chr6:101118450 C/T cg12253828 chr6:101329408 ASCC3 0.86 5.95 0.31 6.94e-9 Economic and political preferences (immigration/crime); LUSC cis rs1832871 0.672 rs9457362 chr6:158772052 C/T cg07165851 chr6:158734300 TULP4 0.47 7.16 0.36 5.2e-12 Height; LUSC cis rs9472414 0.510 rs227853 chr6:44699746 T/C cg20913747 chr6:44695427 NA 0.37 5.82 0.3 1.42e-8 Height; LUSC cis rs3862435 0.572 rs2601183 chr15:90925721 T/G cg22089800 chr15:90895588 ZNF774 0.57 6.09 0.32 3.14e-9 Response to exercise (triglyceride level interaction); LUSC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs3820068 0.608 rs58140482 chr1:16043979 A/G cg24675056 chr1:15929824 NA 0.41 6.84 0.35 3.9e-11 Systolic blood pressure; LUSC cis rs7829975 0.742 rs7832968 chr8:8652889 G/A cg08975724 chr8:8085496 FLJ10661 0.53 7.68 0.39 1.81e-13 Mood instability; LUSC cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg25817165 chr18:72167213 CNDP2 -0.75 -9.0 -0.44 1.8e-17 Refractive error; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg13560548 chr3:10150139 C3orf24 0.55 7.42 0.38 9.5e-13 Alzheimer's disease; LUSC cis rs7940866 0.903 rs1433980 chr11:130870956 A/G cg12179176 chr11:130786555 SNX19 0.58 9.23 0.45 3.19e-18 Schizophrenia; LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.46 -0.5 2.44e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs713587 0.935 rs11676272 chr2:25141538 A/G cg15423357 chr2:25149977 NA 0.48 9.53 0.46 3.25e-19 Body mass index in non-asthmatics; LUSC cis rs72781680 1.000 rs72796389 chr2:24171761 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs7568458 0.846 rs6743030 chr2:85763520 C/T cg23752985 chr2:85803571 VAMP8 0.31 6.38 0.33 5.84e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg03146154 chr1:46216737 IPP 0.52 7.63 0.39 2.52e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.51 -0.34 2.75e-10 Neutrophil percentage of white cells; LUSC cis rs7215564 0.818 rs1531946 chr17:78630807 G/A cg09596252 chr17:78655493 RPTOR 0.56 5.76 0.3 1.88e-8 Myopia (pathological); LUSC cis rs12980942 0.872 rs7248164 chr19:41807700 G/A cg25627403 chr19:41769009 HNRNPUL1 0.6 6.56 0.34 2.08e-10 Coronary artery disease; LUSC cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg01256987 chr12:42539512 GXYLT1 -0.45 -8.45 -0.42 9.42e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10207060 0.500 rs72992168 chr2:240712932 G/A cg07506560 chr2:240697449 NA 0.44 6.9 0.35 2.67e-11 Obesity-related traits; LUSC cis rs617219 0.853 rs58150362 chr5:78519538 A/T cg24856658 chr5:78533917 JMY -0.3 -5.98 -0.31 5.84e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9341808 0.538 rs7756067 chr6:81019794 C/T cg08355045 chr6:80787529 NA -0.4 -6.95 -0.36 1.93e-11 Sitting height ratio; LUSC cis rs8179 0.645 rs11771637 chr7:92260161 G/A cg15732164 chr7:92237376 CDK6 -0.43 -5.92 -0.31 8.06e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg06494592 chr3:125709126 NA -0.5 -5.76 -0.3 1.87e-8 Blood pressure (smoking interaction); LUSC cis rs4242434 0.819 rs6558173 chr8:22492103 A/C cg03733263 chr8:22462867 KIAA1967 -0.87 -15.13 -0.64 9.36e-40 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC trans rs9929218 0.911 rs4783685 chr16:68834107 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.12 -0.52 1.18e-24 Colorectal cancer; LUSC cis rs36093844 0.800 rs78681528 chr11:85588156 T/G cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg18099408 chr3:52552593 STAB1 -0.42 -7.19 -0.37 4.35e-12 Bipolar disorder; LUSC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg16325326 chr1:53192061 ZYG11B 0.97 19.12 0.72 1.4e-55 Monocyte count; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg13942604 chr11:14542103 PSMA1 0.52 6.11 0.32 2.72e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7107174 1.000 rs12270434 chr11:78103300 G/A cg02023728 chr11:77925099 USP35 0.46 6.85 0.35 3.58e-11 Testicular germ cell tumor; LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.78 0.35 5.37e-11 Platelet count; LUSC cis rs11971779 0.555 rs4728466 chr7:139096365 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg25703541 chr22:24373054 LOC391322 -1.01 -19.76 -0.73 4.07e-58 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4740619 0.590 rs4247294 chr9:16030960 C/T cg14451791 chr9:16040625 NA -0.31 -5.89 -0.31 9.28e-9 Body mass index; LUSC cis rs1949733 0.523 rs16842560 chr4:8544238 G/A cg13073564 chr4:8508604 NA 0.34 6.23 0.32 1.44e-9 Response to antineoplastic agents; LUSC cis rs929354 0.772 rs10230895 chr7:157007038 T/C cg05182265 chr7:156933206 UBE3C -0.61 -10.03 -0.48 7e-21 Body mass index; LUSC trans rs11098499 0.657 rs4463052 chr4:120313258 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs9660992 0.736 rs1180734 chr1:205255438 A/G cg00857998 chr1:205179979 DSTYK 0.52 7.83 0.39 6.48e-14 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7171869 1 rs7171869 chr15:78900909 A/G cg24631222 chr15:78858424 CHRNA5 -0.68 -9.07 -0.44 1.07e-17 Post bronchodilator FEV1; LUSC cis rs131777 0.708 rs131749 chr22:51024624 C/T cg00083937 chr22:51039805 MAPK8IP2 -0.5 -8.27 -0.41 3.19e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg07507251 chr3:52567010 NT5DC2 0.29 5.66 0.3 3.28e-8 Bipolar disorder; LUSC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg05313129 chr8:58192883 C8orf71 -0.53 -6.85 -0.35 3.6e-11 Developmental language disorder (linguistic errors); LUSC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg17264618 chr3:40429014 ENTPD3 0.36 7.35 0.37 1.54e-12 Renal cell carcinoma; LUSC cis rs9815354 0.767 rs73079325 chr3:41864565 G/A cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.6e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.4 6.19 0.32 1.72e-9 Menopause (age at onset); LUSC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg09323728 chr8:95962352 TP53INP1 -0.38 -7.75 -0.39 1.14e-13 Type 2 diabetes; LUSC cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg22782873 chr19:19639568 YJEFN3 -0.48 -6.11 -0.32 2.7e-9 Bipolar disorder; LUSC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg18512352 chr11:47633146 NA -0.47 -9.32 -0.45 1.62e-18 Subjective well-being; LUSC cis rs6087990 0.568 rs853854 chr20:31420757 T/A cg13636640 chr20:31349939 DNMT3B 0.86 16.69 0.67 6.46e-46 Ulcerative colitis; LUSC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs7607369 0.782 rs639913 chr2:219365971 A/C cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.07 0.48 5.08e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18404041 chr3:52824283 ITIH1 -0.47 -8.96 -0.44 2.33e-17 Bipolar disorder; LUSC cis rs644799 0.544 rs1254935 chr11:95631470 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.5 0.46 4.33e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg04141948 chr7:1023156 CYP2W1 0.29 5.7 0.3 2.66e-8 Longevity;Endometriosis; LUSC cis rs72627509 0.951 rs72627508 chr4:57831564 C/G cg26694713 chr4:57773883 REST 0.48 5.67 0.3 3.08e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg08999081 chr20:33150536 PIGU 0.44 8.0 0.4 2.02e-14 Coronary artery disease; LUSC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg22875332 chr1:76189707 ACADM 0.79 13.53 0.59 1.51e-33 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs35110281 0.774 rs9978811 chr21:44998683 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 9.27 0.45 2.38e-18 Mean corpuscular volume; LUSC cis rs710216 0.917 rs4660691 chr1:43417150 T/G cg03128534 chr1:43423976 SLC2A1 -0.45 -5.92 -0.31 8.03e-9 Red cell distribution width; LUSC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs977987 0.815 rs4887829 chr16:75488935 C/T cg04384234 chr16:75411784 CFDP1 -0.45 -7.42 -0.38 9.51e-13 Dupuytren's disease; LUSC cis rs4356932 0.967 rs13113455 chr4:76972447 C/T cg00809888 chr4:76862425 NAAA 0.35 5.86 0.31 1.11e-8 Blood protein levels; LUSC cis rs6087990 0.735 rs6119946 chr20:31329704 A/G cg13636640 chr20:31349939 DNMT3B -0.95 -20.02 -0.74 3.75e-59 Ulcerative colitis; LUSC cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg16339924 chr4:17578868 LAP3 -0.49 -7.47 -0.38 7.22e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.93 -0.35 2.23e-11 Lung cancer; LUSC cis rs7937682 0.632 rs7128862 chr11:111755435 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.47 0.56 1.46e-29 Primary sclerosing cholangitis; LUSC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg25036284 chr2:26402008 FAM59B -0.69 -9.7 -0.47 9.48e-20 Gut microbiome composition (summer); LUSC cis rs2637266 0.626 rs846616 chr10:78547311 A/G cg18941641 chr10:78392320 NA 0.39 7.18 0.37 4.46e-12 Pulmonary function; LUSC cis rs9902453 1.000 rs4350617 chr17:28423088 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.59 0.43 3.35e-16 Coffee consumption (cups per day); LUSC cis rs11587400 0.593 rs2336365 chr1:115175415 G/T cg12756093 chr1:115239321 AMPD1 -0.42 -6.4 -0.33 5.12e-10 Autism; LUSC cis rs2346177 0.542 rs13020043 chr2:46698431 A/T cg26688816 chr2:46740690 ATP6V1E2 -0.59 -9.27 -0.45 2.29e-18 HDL cholesterol; LUSC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg25456477 chr12:86230367 RASSF9 0.44 7.87 0.4 4.92e-14 Major depressive disorder; LUSC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg02564969 chr6:151773285 C6orf211;RMND1 0.44 6.65 0.34 1.2e-10 Menarche (age at onset); LUSC trans rs35110281 0.713 rs1378079 chr21:45011187 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 9.09 0.45 8.94e-18 Mean corpuscular volume; LUSC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg26695010 chr11:65641043 EFEMP2 -0.47 -6.93 -0.35 2.18e-11 Eosinophil percentage of white cells; LUSC cis rs6546886 0.912 rs10191539 chr2:74269926 T/C cg14702570 chr2:74259524 NA -0.31 -5.79 -0.3 1.65e-8 Dialysis-related mortality; LUSC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg21171335 chr12:122356390 WDR66 -0.62 -9.68 -0.47 1.06e-19 Mean corpuscular volume; LUSC cis rs7824557 0.933 rs6601576 chr8:11100275 A/T cg21775007 chr8:11205619 TDH -0.49 -7.47 -0.38 7.1e-13 Retinal vascular caliber; LUSC cis rs9393777 0.557 rs6933999 chr6:27074929 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.37 -6.24 -0.32 1.33e-9 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.638 rs9973536 chr2:100942243 C/T cg12002119 chr2:101014098 CHST10 0.34 5.7 0.3 2.63e-8 Intelligence (multi-trait analysis); LUSC cis rs4964805 0.626 rs4964827 chr12:104177081 G/T cg02344784 chr12:104178138 NT5DC3 0.41 6.6 0.34 1.62e-10 Attention deficit hyperactivity disorder; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg16103275 chr6:290800 DUSP22 0.41 6.87 0.35 3.12e-11 Menopause (age at onset); LUSC cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg23711669 chr6:146136114 FBXO30 0.9 16.67 0.67 7.62e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.45 6.25 0.32 1.22e-9 Multiple sclerosis; LUSC trans rs61931739 1.000 rs12427279 chr12:34025898 T/G cg13010199 chr12:38710504 ALG10B -0.4 -6.01 -0.31 4.91e-9 Morning vs. evening chronotype; LUSC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.6 -0.47 1.94e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs35146811 0.700 rs4729579 chr7:99780282 C/G cg19116668 chr7:99932089 PMS2L1 -0.33 -5.66 -0.3 3.25e-8 Coronary artery disease; LUSC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg25456477 chr12:86230367 RASSF9 0.44 7.87 0.4 4.91e-14 Major depressive disorder; LUSC cis rs10779751 1.000 rs4845859 chr1:11304873 A/G cg08854313 chr1:11322531 MTOR 0.87 14.95 0.63 4.62e-39 Body mass index; LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg09034736 chr1:150693464 HORMAD1 0.46 6.49 0.33 3.16e-10 Melanoma; LUSC cis rs17102884 0.506 rs4899541 chr14:75403437 T/G cg08847533 chr14:75593920 NEK9 -0.55 -8.18 -0.41 6.01e-15 Neuroticism; LUSC trans rs2926702 0.810 rs2958368 chr8:71167612 G/A cg16517358 chr11:46164796 NA -0.4 -6.01 -0.31 4.99e-9 Non-small cell lung cancer; LUSC cis rs1577917 1.000 rs12201735 chr6:86656939 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.65 -0.34 1.21e-10 Response to antipsychotic treatment; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04197313 chr15:67547198 IQCH;AAGAB -0.38 -6.62 -0.34 1.43e-10 Electrocardiographic conduction measures; LUSC cis rs11072804 1 rs11072804 chr15:79078486 T/G cg00540400 chr15:79124168 NA -0.4 -6.99 -0.36 1.46e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.65 0.43 2.18e-16 Prudent dietary pattern; LUSC trans rs853679 0.713 rs200991 chr6:27815494 A/C cg06606381 chr12:133084897 FBRSL1 0.53 6.05 0.31 3.94e-9 Depression; LUSC cis rs12137294 0.761 rs1172150 chr1:205221861 A/G cg21643547 chr1:205240462 TMCC2 -0.35 -6.4 -0.33 5.2e-10 Red cell distribution width; LUSC cis rs9303542 0.559 rs12603976 chr17:46617163 C/A cg09704116 chr17:46666958 LOC404266 -0.38 -6.69 -0.34 9.51e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg00012203 chr2:219082015 ARPC2 0.69 11.37 0.53 1.56e-25 Colorectal cancer; LUSC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg12463550 chr7:65579703 CRCP 0.42 5.79 0.3 1.58e-8 Aortic root size; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14751398 chr6:20402153 E2F3 0.45 6.29 0.33 9.91e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11955175 0.850 rs111959286 chr5:40704141 A/T cg04002187 chr5:40835754 RPL37 0.68 5.78 0.3 1.69e-8 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg11062466 chr8:58055876 NA 0.67 8.14 0.41 7.83e-15 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg07092213 chr7:1199455 ZFAND2A -0.53 -8.53 -0.42 5.3e-16 Longevity;Endometriosis; LUSC trans rs3733585 0.674 rs7375643 chr4:9955239 A/G cg26043149 chr18:55253948 FECH -0.45 -6.99 -0.36 1.47e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7215564 0.908 rs4243241 chr17:78660502 A/C cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg19901468 chr14:105411992 AHNAK2 0.73 12.97 0.58 1.91e-31 Rheumatoid arthritis; LUSC cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg03146154 chr1:46216737 IPP -0.52 -7.39 -0.37 1.21e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.35 2.06e-11 Monocyte percentage of white cells; LUSC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.35 6.53 0.34 2.47e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7584330 0.910 rs7606177 chr2:238394913 G/C cg16989719 chr2:238392110 NA -0.42 -7.45 -0.38 7.96e-13 Prostate cancer; LUSC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.88e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12575480 0.709 rs7107076 chr11:2094303 C/T cg15541987 chr11:2077307 NA -0.45 -6.79 -0.35 5.05e-11 Pursuit maintenance gain; LUSC cis rs8028313 0.609 rs28735117 chr15:67933892 C/T cg24579218 chr15:68104479 NA -0.37 -6.34 -0.33 7.64e-10 Obesity; LUSC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg27121462 chr16:89883253 FANCA 0.55 9.02 0.44 1.52e-17 Vitiligo; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22481535 chr5:14581529 FAM105A -0.4 -6.1 -0.32 2.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.95 0.31 6.78e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg21724239 chr8:58056113 NA 0.59 6.82 0.35 4.19e-11 Developmental language disorder (linguistic errors); LUSC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg12927641 chr6:109611667 NA -0.43 -7.58 -0.38 3.41e-13 Reticulocyte fraction of red cells; LUSC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg16423285 chr20:60520624 NA -0.47 -5.82 -0.3 1.38e-8 Body mass index; LUSC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg27432699 chr2:27873401 GPN1 -0.56 -8.31 -0.41 2.49e-15 Total body bone mineral density; LUSC cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg05347473 chr6:146136440 FBXO30 0.46 7.89 0.4 4.32e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1371867 0.846 rs1788181 chr8:101334068 C/T cg06636551 chr8:101224915 SPAG1 -0.38 -7.13 -0.36 6.31e-12 Atrioventricular conduction; LUSC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg03538708 chr1:25844672 NA -0.37 -6.11 -0.32 2.71e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.56 0.34 2.09e-10 Menopause (age at onset); LUSC cis rs34779708 0.966 rs11010102 chr10:35411066 T/A cg03585969 chr10:35415529 CREM 0.6 8.96 0.44 2.37e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4654899 0.865 rs10916927 chr1:21385795 T/C cg01072550 chr1:21505969 NA -0.49 -7.11 -0.36 6.9e-12 Superior frontal gyrus grey matter volume; LUSC cis rs11711311 0.955 rs12636536 chr3:113474226 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.78 -0.3 1.7e-8 IgG glycosylation; LUSC cis rs497273 0.534 rs13746 chr12:121201167 C/T cg02419362 chr12:121203948 SPPL3 0.44 8.0 0.4 2.09e-14 Systemic lupus erythematosus; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg11905131 chr22:24372483 LOC391322 -0.57 -9.6 -0.46 2.01e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg26314531 chr2:26401878 FAM59B -0.7 -9.84 -0.47 3.09e-20 Gut microbiome composition (summer); LUSC trans rs877282 1.000 rs11253367 chr10:773389 G/A cg22713356 chr15:30763199 NA 1.09 15.62 0.65 1.13e-41 Uric acid levels; LUSC cis rs7914558 0.646 rs1046778 chr10:104661484 T/C cg05855489 chr10:104503620 C10orf26 0.42 5.76 0.3 1.92e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9300255 0.596 rs7304782 chr12:123719444 A/G cg13010344 chr12:123464640 ARL6IP4 0.45 6.83 0.35 3.99e-11 Neutrophil percentage of white cells; LUSC cis rs9788721 1.000 rs10519203 chr15:78814046 C/T cg18825076 chr15:78729989 IREB2 0.51 8.14 0.41 8.11e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg04414720 chr1:150670196 GOLPH3L -0.41 -6.26 -0.32 1.2e-9 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg06740227 chr12:86229804 RASSF9 0.44 6.92 0.35 2.29e-11 Major depressive disorder; LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg13732083 chr21:47605072 C21orf56 0.41 5.93 0.31 7.66e-9 Testicular germ cell tumor; LUSC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.6 10.63 0.5 6.43e-23 Menopause (age at onset); LUSC cis rs2404602 0.647 rs11631959 chr15:77040048 T/C cg23625390 chr15:77176239 SCAPER -0.66 -10.06 -0.48 5.61e-21 Blood metabolite levels; LUSC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg14019146 chr3:50243930 SLC38A3 0.32 6.91 0.35 2.49e-11 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs36077931 chr16:48594221 A/G cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6835098 0.924 rs2332669 chr4:174163398 G/A cg08422745 chr4:174089978 GALNT7 -0.74 -12.0 -0.55 8.21e-28 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs11864453 0.793 rs7197869 chr16:72079352 G/C cg16558253 chr16:72132732 DHX38 -0.43 -6.58 -0.34 1.86e-10 Fibrinogen levels; LUSC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg02891314 chr5:179741120 GFPT2 -0.57 -9.34 -0.45 1.44e-18 Height; LUSC cis rs950776 0.518 rs11630349 chr15:78824608 C/T cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs4919694 1.000 rs7100592 chr10:104769098 T/G cg04362960 chr10:104952993 NT5C2 1.17 13.71 0.6 3.13e-34 Arsenic metabolism; LUSC cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg05283184 chr6:79620031 NA -0.58 -12.44 -0.56 1.93e-29 Intelligence (multi-trait analysis); LUSC trans rs2204008 0.837 rs11168504 chr12:37964922 G/T cg06521331 chr12:34319734 NA -0.4 -6.03 -0.31 4.34e-9 Bladder cancer; LUSC trans rs6502050 0.799 rs12603050 chr17:80104631 A/G cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs3764021 0.840 rs12304510 chr12:9885526 C/T cg20894963 chr12:9885564 CLECL1 0.34 6.98 0.36 1.64e-11 Type 1 diabetes; LUSC cis rs34421088 0.560 rs2248325 chr8:11396874 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.9 -0.31 8.95e-9 Neuroticism; LUSC cis rs11155671 0.530 rs9397398 chr6:150193603 G/A cg09699651 chr6:150184138 LRP11 0.38 5.95 0.31 6.81e-9 Testicular germ cell tumor; LUSC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.73 -12.49 -0.56 1.23e-29 Total body bone mineral density; LUSC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg09021430 chr5:549028 NA -0.56 -7.58 -0.38 3.35e-13 Obesity-related traits; LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg24503407 chr1:205819492 PM20D1 0.52 7.58 0.38 3.41e-13 Prostate-specific antigen levels; LUSC cis rs6547741 0.904 rs2384659 chr2:27856793 G/A cg12559939 chr2:27858050 GPN1 0.41 6.26 0.32 1.21e-9 Oral cavity cancer; LUSC trans rs9951602 1.000 rs7232284 chr18:76667529 A/G cg02800362 chr5:177631904 HNRNPAB 0.74 7.97 0.4 2.51e-14 Obesity-related traits; LUSC cis rs10791097 0.720 rs6590517 chr11:130733505 C/T cg12179176 chr11:130786555 SNX19 0.74 11.61 0.54 2.03e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg27535305 chr1:53392650 SCP2 -0.4 -7.43 -0.38 9.16e-13 Monocyte count; LUSC cis rs4319547 0.774 rs7954006 chr12:123131824 A/C cg23029597 chr12:123009494 RSRC2 0.6 8.61 0.43 2.93e-16 Body mass index; LUSC cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg17261708 chr5:176794207 RGS14 0.34 6.0 0.31 5.11e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs4950928 0.823 rs7541061 chr1:203163367 G/T cg17014757 chr1:203156097 CHI3L1 0.42 7.38 0.37 1.28e-12 YKL-40 levels; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg04025307 chr7:1156635 C7orf50 0.55 8.64 0.43 2.38e-16 Longevity;Endometriosis; LUSC trans rs6762477 0.748 rs11711407 chr3:50225029 A/G cg21659725 chr3:3221576 CRBN -0.48 -7.29 -0.37 2.29e-12 Menarche (age at onset); LUSC trans rs12579753 0.872 rs34415838 chr12:82122078 T/C cg07923666 chr12:49932857 KCNH3 -0.52 -6.46 -0.33 3.8e-10 Resting heart rate; LUSC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg04352962 chr1:209979756 IRF6 0.53 6.16 0.32 2.08e-9 Cleft lip with or without cleft palate; LUSC cis rs965469 1.000 rs6051792 chr20:3343519 T/C cg25506879 chr20:3388711 C20orf194 -0.52 -5.68 -0.3 2.87e-8 IFN-related cytopenia; LUSC cis rs2180341 0.513 rs12196828 chr6:127696864 C/T cg27446573 chr6:127587934 RNF146 0.62 9.83 0.47 3.32e-20 Breast cancer; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg27094323 chr7:1216898 NA -0.46 -8.14 -0.41 8.08e-15 Longevity;Endometriosis; LUSC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg24209194 chr3:40518798 ZNF619 0.45 6.1 0.32 2.87e-9 Renal cell carcinoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24185116 chr15:52044314 LYSMD2;TMOD2 0.4 6.16 0.32 2.12e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2197308 0.565 rs12809769 chr12:37909968 C/T cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26421286 chr17:16439070 NA 0.73 6.26 0.32 1.19e-9 Cognitive performance; LUSC cis rs7568458 0.684 rs7579147 chr2:85805654 G/A cg23752985 chr2:85803571 VAMP8 0.34 6.5 0.34 2.86e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6901250 0.851 rs7760125 chr6:117123391 A/C cg12892004 chr6:117198278 RFX6 0.43 8.12 0.41 9.06e-15 C-reactive protein levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14777817 chr13:80055594 NDFIP2 -0.47 -6.16 -0.32 2.06e-9 Bipolar disorder and schizophrenia; LUSC cis rs10911251 0.546 rs2027081 chr1:183074576 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.8 0.51 1.65e-23 Colorectal cancer; LUSC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg08975724 chr8:8085496 FLJ10661 -0.64 -9.32 -0.45 1.67e-18 Schizophrenia; LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.13 0.36 6.07e-12 Bipolar disorder; LUSC cis rs4363385 0.818 rs4845335 chr1:152993955 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.7 -0.3 2.66e-8 Inflammatory skin disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20314438 chr6:126661369 C6orf173 0.45 7.0 0.36 1.43e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg12442385 chr7:1034912 NA -0.34 -5.68 -0.3 2.88e-8 Longevity;Endometriosis; LUSC cis rs10751667 0.600 rs7394783 chr11:1005108 C/T cg06064525 chr11:970664 AP2A2 0.28 5.69 0.3 2.83e-8 Alzheimer's disease (late onset); LUSC cis rs1160297 0.609 rs7577692 chr2:53105969 T/C cg07782112 chr2:53107842 NA 0.42 6.79 0.35 5.01e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.5 -0.38 5.86e-13 Bipolar disorder; LUSC cis rs4919694 1.000 rs58317752 chr10:104799267 T/A cg04362960 chr10:104952993 NT5C2 1.18 13.88 0.6 7.01e-35 Arsenic metabolism; LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.11e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs244293 0.695 rs9303360 chr17:53001456 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -6.1 -0.32 2.88e-9 Menarche (age at onset); LUSC trans rs2739330 0.828 rs4822454 chr22:24255208 G/A cg06437703 chr8:37914619 EIF4EBP1 -0.56 -8.66 -0.43 2e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg14004847 chr7:1930337 MAD1L1 -0.57 -8.8 -0.43 7.73e-17 Bipolar disorder and schizophrenia; LUSC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg11342453 chr6:26196699 NA 0.59 6.12 0.32 2.6e-9 Gout;Renal underexcretion gout; LUSC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs1185460 0.934 rs10892328 chr11:118942654 T/A cg01677386 chr11:118938358 VPS11 -0.48 -6.42 -0.33 4.75e-10 Coronary artery disease; LUSC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg20712883 chr12:51590929 POU6F1 0.46 6.6 0.34 1.65e-10 Cisplatin-induced ototoxicity; LUSC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg13628971 chr7:2884303 GNA12 0.5 7.15 0.36 5.48e-12 Height; LUSC cis rs17685 0.712 rs28506984 chr7:75763484 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.19e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4919087 1.000 rs7067835 chr10:99074649 T/C cg25902810 chr10:99078978 FRAT1 0.47 6.91 0.35 2.47e-11 Monocyte count; LUSC cis rs611744 0.647 rs1448150 chr8:109276161 T/C cg18478394 chr8:109455254 TTC35 0.43 6.79 0.35 5.05e-11 Dupuytren's disease; LUSC cis rs262150 0.536 rs4909109 chr7:158787168 C/G cg19418458 chr7:158789849 NA 0.51 6.75 0.35 6.5500000000000006e-11 Facial morphology (factor 20); LUSC cis rs1163251 0.869 rs629735 chr1:120206932 G/T cg19096424 chr1:120255104 PHGDH -0.49 -6.83 -0.35 4.15e-11 Blood metabolite levels; LUSC cis rs59698941 0.943 rs56927472 chr5:132226038 T/A cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.45e-11 Apolipoprotein A-IV levels; LUSC cis rs7202877 0.611 rs7187263 chr16:75308978 C/A cg03315344 chr16:75512273 CHST6 0.43 6.2 0.32 1.71e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg17294928 chr15:75287854 SCAMP5 -0.94 -13.55 -0.6 1.27e-33 Blood trace element (Zn levels); LUSC cis rs4363385 0.818 rs472076 chr1:153013742 G/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.15 -0.36 5.38e-12 Inflammatory skin disease; LUSC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.27 0.41 3.24e-15 Age-related macular degeneration (geographic atrophy); LUSC trans rs6601327 0.641 rs12155819 chr8:9572679 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -6.29 -0.33 1e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs6840360 0.593 rs6847844 chr4:152693246 C/T cg22705602 chr4:152727874 NA -0.39 -8.43 -0.42 1.05e-15 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs427941 0.667 rs34247954 chr7:101740993 C/T cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs11098499 0.739 rs9996382 chr4:120151012 C/T cg24375607 chr4:120327624 NA 0.63 9.81 0.47 3.88e-20 Corneal astigmatism; LUSC cis rs7712401 0.584 rs30037 chr5:122277990 T/C cg19077854 chr5:122220652 SNX24 0.41 9.16 0.45 5.23e-18 Mean platelet volume; LUSC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg13939156 chr17:80058883 NA -0.33 -6.65 -0.34 1.22e-10 Life satisfaction; LUSC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg11062466 chr8:58055876 NA 0.49 6.3 0.33 9.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs559928 0.597 rs2186572 chr11:63895887 A/G cg24687543 chr11:63912206 MACROD1 0.46 5.93 0.31 7.47e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs8068544 0.818 rs78333491 chr17:40163138 A/G cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -1.24 -11.41 -0.53 1.14e-25 Reticulocyte fraction of red cells;Reticulocyte count; LUSC trans rs853679 0.599 rs156743 chr6:27967089 T/C cg06606381 chr12:133084897 FBRSL1 -0.65 -6.88 -0.35 3.02e-11 Depression; LUSC cis rs8072100 0.875 rs4794047 chr17:45763005 A/T cg08085267 chr17:45401833 C17orf57 0.47 7.41 0.38 1.04e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2219968 0.884 rs9643433 chr8:78952371 T/A cg00738934 chr8:78996279 NA 0.37 6.64 0.34 1.28e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7608623 0.773 rs11683876 chr2:23921170 G/A cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC trans rs800082 0.501 rs9873732 chr3:144191665 C/T cg24215973 chr2:240111563 HDAC4 0.51 7.78 0.39 9.25e-14 Smoking behavior; LUSC cis rs9560113 0.580 rs9560115 chr13:112193619 G/A cg10483660 chr13:112241077 NA 0.38 6.92 0.35 2.36e-11 Menarche (age at onset); LUSC cis rs11605924 0.935 rs6485645 chr11:45862353 A/G ch.11.939596F chr11:45881766 CRY2 -0.5 -7.33 -0.37 1.75e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs3749237 0.964 rs7431078 chr3:49808190 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.52 7.11 0.36 7.24e-12 Resting heart rate; LUSC cis rs2228479 0.681 rs62052184 chr16:89967217 T/C cg06558623 chr16:89946397 TCF25 0.96 10.22 0.49 1.66e-21 Skin colour saturation; LUSC cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg18964960 chr10:1102726 WDR37 -0.44 -5.87 -0.31 1.05e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs4363385 0.510 rs11205187 chr1:153053323 T/C cg00922841 chr1:152955080 SPRR1A -0.4 -6.63 -0.34 1.33e-10 Inflammatory skin disease; LUSC cis rs611744 0.563 rs7815105 chr8:109298794 C/T cg21045802 chr8:109455806 TTC35 0.46 6.71 0.34 8.21e-11 Dupuytren's disease; LUSC cis rs826838 1.000 rs851934 chr12:39104453 G/T cg26384229 chr12:38710491 ALG10B -0.83 -15.64 -0.65 9.29e-42 Heart rate; LUSC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3857536 0.813 rs2040591 chr6:66945915 A/G cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs10782582 0.609 rs1796815 chr1:76396793 T/G cg10523679 chr1:76189770 ACADM -0.44 -6.31 -0.33 8.67e-10 Daytime sleep phenotypes; LUSC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg05425664 chr17:57184151 TRIM37 -0.58 -8.86 -0.44 4.84e-17 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC trans rs11098499 0.954 rs3733523 chr4:120423719 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg21017887 chr14:105400489 NA 0.7 13.23 0.59 1.99e-32 Rheumatoid arthritis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10694539 chr12:42538536 GXYLT1 -0.44 -6.44 -0.33 4.2e-10 Electrocardiographic conduction measures; LUSC cis rs76935404 0.811 rs4609955 chr19:41433613 T/C cg04176888 chr19:41596066 CYP2A13 0.36 5.74 0.3 2.13e-8 nicotine metabolite ratio in current smokers; LUSC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9925964 0.935 rs12597511 chr16:31145219 C/T cg02466173 chr16:30829666 NA 0.33 6.13 0.32 2.52e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.77 0.57 1.12e-30 Chronic sinus infection; LUSC cis rs977987 0.806 rs8056236 chr16:75448273 C/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.62 -0.34 1.4e-10 Dupuytren's disease; LUSC cis rs7572644 0.739 rs10204488 chr2:28132250 G/A cg27432699 chr2:27873401 GPN1 -0.53 -6.89 -0.35 2.87e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg20406979 chr6:167373233 NA -0.26 -6.0 -0.31 5.13e-9 Crohn's disease; LUSC cis rs7746199 0.736 rs13192965 chr6:27671825 G/A cg26958806 chr6:27640298 NA 0.75 6.01 0.31 4.76e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg21724239 chr8:58056113 NA 0.81 9.65 0.47 1.4e-19 Developmental language disorder (linguistic errors); LUSC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg24550644 chr17:30846204 MYO1D -0.36 -5.71 -0.3 2.47e-8 Schizophrenia; LUSC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -12.41 -0.56 2.45e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg12639453 chr1:2035780 PRKCZ -0.32 -6.58 -0.34 1.84e-10 Height; LUSC cis rs6977660 0.507 rs72591449 chr7:19775443 T/C cg05791153 chr7:19748676 TWISTNB 0.91 8.99 0.44 1.91e-17 Thyroid stimulating hormone; LUSC cis rs4851254 0.618 rs13033732 chr2:100644797 A/G cg07810366 chr2:100720526 AFF3 -0.46 -5.95 -0.31 6.76e-9 Intelligence (multi-trait analysis); LUSC cis rs500891 0.525 rs1144179 chr6:84026572 C/G cg08257003 chr6:84140564 ME1 0.35 8.25 0.41 3.68e-15 Platelet-derived growth factor BB levels; LUSC cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg26395211 chr5:140044315 WDR55 -0.39 -5.95 -0.31 6.75e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs8077889 0.672 rs2106764 chr17:41852717 T/A cg26893861 chr17:41843967 DUSP3 1.09 23.59 0.79 4.2e-73 Triglycerides; LUSC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg19257562 chr1:2043853 PRKCZ 0.33 6.74 0.35 7.03e-11 Height; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07537819 chr6:156886127 NA -0.36 -6.09 -0.32 3.14e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg03354898 chr7:1950403 MAD1L1 -0.36 -6.93 -0.35 2.15e-11 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg04369109 chr6:150039330 LATS1 -0.58 -8.56 -0.42 4.25e-16 Lung cancer; LUSC cis rs7106204 0.590 rs28864378 chr11:24206582 C/A ch.11.24196551F chr11:24239977 NA 1.09 12.65 0.57 3.2e-30 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg19622623 chr12:86230825 RASSF9 0.43 6.3 0.33 9.65e-10 Major depressive disorder; LUSC trans rs7824557 0.564 rs2736300 chr8:11235579 T/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.01e-14 Retinal vascular caliber; LUSC cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg03060546 chr3:49711283 APEH -0.52 -7.57 -0.38 3.66e-13 Resting heart rate; LUSC cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg13531842 chr10:38383804 ZNF37A -0.44 -6.71 -0.34 8.14e-11 Extrinsic epigenetic age acceleration; LUSC cis rs10911232 0.507 rs4651138 chr1:183001312 C/A ch.1.3577855R chr1:183094577 LAMC1 0.71 11.0 0.52 3.18e-24 Hypertriglyceridemia; LUSC cis rs790123 0.842 rs2650958 chr3:122396187 A/T cg17380795 chr3:122379686 NA 0.36 5.79 0.3 1.66e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs7113850 0.541 rs76166238 chr11:24235418 G/A ch.11.24196551F chr11:24239977 NA 1.0 9.09 0.45 9.2e-18 Bone fracture in osteoporosis; LUSC cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg05985134 chr18:33552581 C18orf21 0.52 7.27 0.37 2.62e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg01689657 chr7:91764605 CYP51A1 -0.34 -6.18 -0.32 1.84e-9 Breast cancer; LUSC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg23188684 chr11:67383651 NA 0.41 7.32 0.37 1.85e-12 Mean corpuscular volume; LUSC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11890956 chr21:40555474 PSMG1 0.96 17.39 0.69 1.06e-48 Cognitive function; LUSC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg02423579 chr7:2872169 GNA12 -0.42 -6.21 -0.32 1.6e-9 Height; LUSC cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg07606381 chr6:8435919 SLC35B3 0.74 12.78 0.57 9.82e-31 Motion sickness; LUSC cis rs67539049 1.000 rs73546310 chr8:11302501 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.39 -5.97 -0.31 6.07e-9 Itch intensity from mosquito bite; LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs6681460 1.000 rs2147777 chr1:67129254 A/T cg02459107 chr1:67143332 SGIP1 0.48 9.04 0.44 1.34e-17 Presence of antiphospholipid antibodies; LUSC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg03709012 chr19:19516395 GATAD2A 0.87 14.72 0.63 3.76e-38 Tonsillectomy; LUSC cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 6.95 0.36 1.93e-11 Rheumatoid arthritis; LUSC cis rs8038465 1.000 rs8038465 chr15:73978337 A/G cg15420318 chr15:73925796 NPTN -0.4 -6.44 -0.33 4.24e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs977987 0.800 rs4888378 chr16:75332041 A/G cg04384234 chr16:75411784 CFDP1 -0.37 -5.94 -0.31 7.31e-9 Dupuytren's disease; LUSC cis rs7917772 0.582 rs10786695 chr10:104368756 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.08 0.52 1.68e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg15147215 chr3:52552868 STAB1 -0.3 -5.68 -0.3 2.96e-8 Bipolar disorder; LUSC cis rs1003719 0.715 rs2835642 chr21:38539066 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg16386425 chr10:429943 DIP2C -0.44 -7.03 -0.36 1.14e-11 Psychosis in Alzheimer's disease; LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg16325326 chr1:53192061 ZYG11B 0.78 12.57 0.57 6.05e-30 Monocyte count; LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg26690034 chr1:75198963 CRYZ;TYW3 0.38 5.72 0.3 2.33e-8 Resistin levels; LUSC cis rs11190604 1.000 rs3750720 chr10:102248884 C/T cg16342193 chr10:102329863 NA -0.35 -5.97 -0.31 5.98e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.99 -12.96 -0.58 2.14e-31 Chronic sinus infection; LUSC cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg26446133 chr18:72167187 CNDP2 -0.79 -10.62 -0.5 6.95e-23 Refractive error; LUSC cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg05347473 chr6:146136440 FBXO30 0.47 7.75 0.39 1.1e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9486719 1.000 rs12193732 chr6:96942609 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -10.0 -0.48 9.04e-21 Migraine;Coronary artery disease; LUSC cis rs1023500 0.506 rs6002625 chr22:42517689 A/G cg05082376 chr22:42548792 NA 0.39 5.83 0.3 1.29e-8 Schizophrenia; LUSC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg10560079 chr2:191398806 TMEM194B 0.45 7.45 0.38 8.21e-13 Pulse pressure; LUSC cis rs10489202 0.657 rs201541 chr1:167992344 T/A cg24449463 chr1:168025552 DCAF6 -0.78 -13.13 -0.58 4.78e-32 Schizophrenia; LUSC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.63e-10 Life satisfaction; LUSC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.71 0.54 8.73e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7481584 0.669 rs12421922 chr11:3035070 A/G cg05729581 chr11:3078854 CARS 0.4 5.99 0.31 5.55e-9 Calcium levels; LUSC cis rs6845621 0.745 rs1517996 chr4:18863232 G/T cg12196642 chr4:18937545 NA -0.31 -5.82 -0.3 1.39e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg22029157 chr1:209979665 IRF6 -0.72 -8.69 -0.43 1.62e-16 Coronary artery disease; LUSC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg09904177 chr6:26538194 HMGN4 -0.48 -5.94 -0.31 7.23e-9 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg15242686 chr22:24348715 GSTTP1 0.42 6.21 0.32 1.53e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14229702 chr15:89164377 AEN 0.42 6.19 0.32 1.73e-9 Triglycerides; LUSC cis rs9326248 0.559 rs10892052 chr11:116834313 G/A cg20608306 chr11:116969690 SIK3 0.39 7.29 0.37 2.27e-12 Blood protein levels; LUSC cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg08999081 chr20:33150536 PIGU -0.51 -10.33 -0.49 7e-22 Glomerular filtration rate (creatinine); LUSC cis rs3755132 0.929 rs6734471 chr2:15765425 C/T cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg27284194 chr4:1044797 NA 0.35 5.83 0.3 1.32e-8 Obesity-related traits; LUSC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg16339924 chr4:17578868 LAP3 0.54 8.09 0.4 1.14e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7520050 0.807 rs4660312 chr1:46110572 A/G cg24296786 chr1:45957014 TESK2 -0.41 -5.83 -0.3 1.29e-8 Red blood cell count;Reticulocyte count; LUSC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg03351412 chr1:154909251 PMVK 0.54 8.6 0.43 3.1e-16 Prostate cancer; LUSC cis rs796825 0.530 rs4146299 chr3:119999820 A/G cg21790991 chr3:120137480 FSTL1 0.32 6.01 0.31 4.77e-9 HIV-1 susceptibility; LUSC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg15556689 chr8:8085844 FLJ10661 0.69 11.67 0.54 1.29e-26 Mood instability; LUSC cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg00522288 chr12:125625016 AACS -0.31 -6.02 -0.31 4.57e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg05368731 chr17:41323189 NBR1 0.92 15.78 0.65 2.7e-42 Menopause (age at onset); LUSC cis rs9905704 0.681 rs2531730 chr17:56545069 T/G cg19466818 chr17:56409534 MIR142 0.35 6.52 0.34 2.53e-10 Testicular germ cell tumor; LUSC cis rs6456156 0.586 rs9457266 chr6:167482555 T/C cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs899997 0.906 rs1994018 chr15:79025584 G/A cg04896959 chr15:78267971 NA -0.53 -9.98 -0.48 1.05e-20 Coronary artery disease or large artery stroke; LUSC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11644478 chr21:40555479 PSMG1 -0.77 -13.54 -0.6 1.34e-33 Cognitive function; LUSC cis rs2280018 1.000 rs2280018 chr16:15150833 A/C cg27102117 chr16:15229624 NA 0.41 7.05 0.36 1.03e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.42 -5.79 -0.3 1.59e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg21782813 chr7:2030301 MAD1L1 0.49 8.35 0.42 1.8e-15 Bipolar disorder and schizophrenia; LUSC trans rs11992162 0.551 rs35010200 chr8:11785655 G/A cg27411982 chr8:10470053 RP1L1 -0.43 -6.61 -0.34 1.51e-10 Monocyte count; LUSC cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.44e-23 Bladder cancer; LUSC cis rs1448094 0.645 rs8181635 chr12:86465136 C/T cg00310523 chr12:86230176 RASSF9 -0.36 -6.48 -0.33 3.27e-10 Major depressive disorder; LUSC trans rs4332037 0.851 rs10268609 chr7:1962163 A/C cg11693508 chr17:37793320 STARD3 0.59 7.39 0.37 1.21e-12 Bipolar disorder; LUSC cis rs11711311 1.000 rs9826465 chr3:113432254 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.92 0.35 2.31e-11 IgG glycosylation; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg08589821 chr5:55033950 DDX4 -0.42 -6.12 -0.32 2.67e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs9650657 0.740 rs6980805 chr8:10679842 G/C cg27411982 chr8:10470053 RP1L1 -0.39 -6.26 -0.32 1.16e-9 Neuroticism; LUSC trans rs877282 0.583 rs7072970 chr10:822757 G/A cg22713356 chr15:30763199 NA 0.79 10.15 0.49 2.85e-21 Uric acid levels; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg10089324 chr1:51984752 EPS15 0.49 6.28 0.32 1.04e-9 Cognitive function;Information processing speed; LUSC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg17747265 chr1:1875780 NA -0.74 -17.19 -0.69 7.15e-48 Body mass index; LUSC cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.56 -0.34 2.03e-10 Menarche (age at onset); LUSC cis rs61931739 0.534 rs35056575 chr12:34142914 A/T cg06521331 chr12:34319734 NA -0.47 -7.7 -0.39 1.55e-13 Morning vs. evening chronotype; LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg16405210 chr4:1374714 KIAA1530 -0.46 -6.81 -0.35 4.66e-11 Obesity-related traits; LUSC cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg08754478 chr10:133766260 PPP2R2D -0.61 -7.74 -0.39 1.17e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg03188948 chr7:1209495 NA 0.68 7.14 0.36 5.96e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs988712 0.550 rs988748 chr11:27724745 C/G cg10635145 chr11:27742435 BDNF 0.49 6.55 0.34 2.15e-10 Obesity; LUSC cis rs7759001 0.857 rs2393932 chr6:27353197 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs11166629 1.000 rs7818331 chr8:135639653 C/T cg21672855 chr8:135614777 ZFAT 0.36 5.78 0.3 1.68e-8 Smoking quantity; LUSC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.1 0.58 6.37e-32 Total body bone mineral density; LUSC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg02228675 chr17:40259724 DHX58 0.49 6.65 0.34 1.17e-10 Fibrinogen levels; LUSC trans rs853679 0.517 rs9357061 chr6:28051772 A/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs9815354 0.812 rs7639859 chr3:42001987 C/T cg03022575 chr3:42003672 ULK4 0.81 8.53 0.42 5.02e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC cis rs10992471 0.603 rs10992342 chr9:95212068 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.77 -0.39 9.99e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10740039 0.883 rs7918897 chr10:62403512 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.38e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs459571 0.959 rs2073818 chr9:136918662 C/A cg01294253 chr9:136912663 BRD3 0.35 6.09 0.32 3.1e-9 Platelet distribution width; LUSC cis rs68170813 0.599 rs12532849 chr7:106959226 A/C cg02696742 chr7:106810147 HBP1 -0.63 -9.42 -0.46 7.8e-19 Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25439973 chr20:1206758 RAD21L1 0.69 6.23 0.32 1.43e-9 Cognitive performance; LUSC cis rs10751667 0.961 rs6597951 chr11:991530 C/T ch.11.42038R chr11:967971 AP2A2 0.53 7.76 0.39 1.05e-13 Alzheimer's disease (late onset); LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.12 0.41 9.02e-15 Prudent dietary pattern; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18404041 chr3:52824283 ITIH1 -0.61 -11.94 -0.55 1.36e-27 Bipolar disorder; LUSC cis rs472402 0.580 rs3822430 chr5:6651970 A/G cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.54 -7.77 -0.39 1.01e-13 Response to amphetamines; LUSC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg05973401 chr12:123451056 ABCB9 0.55 6.81 0.35 4.68e-11 Neutrophil percentage of white cells; LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg10802521 chr3:52805072 NEK4 -0.41 -6.37 -0.33 6.31e-10 Electroencephalogram traits; LUSC cis rs1215050 0.791 rs2658477 chr4:98850993 G/A cg05340658 chr4:99064831 C4orf37 -0.44 -6.95 -0.36 1.94e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs240764 0.746 rs239197 chr6:101133600 T/C cg09795085 chr6:101329169 ASCC3 0.42 6.21 0.32 1.56e-9 Neuroticism; LUSC cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg22437258 chr11:111473054 SIK2 -0.48 -6.23 -0.32 1.41e-9 Primary sclerosing cholangitis; LUSC cis rs977987 0.806 rs11149832 chr16:75462713 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs12421382 0.593 rs2357793 chr11:109389353 A/T cg27471124 chr11:109292789 C11orf87 0.38 6.94 0.35 2.08e-11 Schizophrenia; LUSC cis rs8062405 0.964 rs72793809 chr16:28832382 C/T cg09754948 chr16:28834200 ATXN2L 0.44 6.43 0.33 4.51e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg13010199 chr12:38710504 ALG10B 0.49 7.5 0.38 5.96e-13 Morning vs. evening chronotype; LUSC cis rs870825 0.929 rs55746424 chr4:185589603 C/T cg04058563 chr4:185651563 MLF1IP 0.88 11.53 0.53 4.02e-26 Blood protein levels; LUSC cis rs709400 0.663 rs11628213 chr14:103952453 A/C cg10523860 chr14:103875565 MARK3 -0.37 -5.82 -0.3 1.37e-8 Body mass index; LUSC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg08677398 chr8:58056175 NA 0.5 5.85 0.3 1.17e-8 Developmental language disorder (linguistic errors); LUSC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg08847533 chr14:75593920 NEK9 0.85 15.73 0.65 4.01e-42 Height; LUSC cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg12165864 chr7:66369176 NA -0.52 -6.93 -0.35 2.19e-11 Corneal structure; LUSC cis rs5009270 0.553 rs6947690 chr7:112233386 C/G cg27282281 chr7:112262583 NA 0.43 5.72 0.3 2.32e-8 Osteoarthritis (hip); LUSC cis rs12956009 0.583 rs1115360 chr18:44894550 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.14 0.32 2.36e-9 Educational attainment (years of education); LUSC cis rs9527 0.590 rs7901197 chr10:104840433 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.5 0.46 4.08e-19 Arsenic metabolism; LUSC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg03676636 chr4:99064102 C4orf37 0.33 7.28 0.37 2.38e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs427941 0.668 rs201459 chr7:101741502 G/A cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg12432903 chr7:1882776 MAD1L1 0.54 6.77 0.35 5.81e-11 Bipolar disorder; LUSC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg03609598 chr5:56110824 MAP3K1 0.41 5.93 0.31 7.7e-9 Initial pursuit acceleration; LUSC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg02079420 chr8:82753780 SNX16 0.43 7.37 0.37 1.39e-12 Diastolic blood pressure; LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs753778 0.667 rs10092439 chr8:142210881 C/T cg18755752 chr8:142205143 DENND3 -0.72 -12.95 -0.58 2.4e-31 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC trans rs236907 0.859 rs35631282 chr1:171760682 C/T cg13482142 chr2:234261155 NA 0.52 6.19 0.32 1.81e-9 Mean platelet volume; LUSC cis rs12220238 1.000 rs10824125 chr10:75997498 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.09 0.36 8.18e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7177699 0.557 rs10083696 chr15:79124016 G/A cg15571903 chr15:79123663 NA -0.36 -6.58 -0.34 1.8e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4791641 1.000 rs4791641 chr17:8161149 C/T cg06726167 chr17:8076949 TMEM107 0.39 6.21 0.32 1.54e-9 LDL cholesterol levels;Hematocrit;Hemoglobin concentration;Red blood cell count;LDL cholesterol; LUSC cis rs12422267 0.536 rs7976530 chr12:132609140 C/T cg09764611 chr12:132620959 NA -0.58 -8.73 -0.43 1.24e-16 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs826838 0.559 rs4882276 chr12:38611994 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.84 0.44 5.5e-17 Heart rate; LUSC trans rs11039798 0.588 rs113800184 chr11:48756855 G/A cg15704280 chr7:45808275 SEPT13 0.72 8.18 0.41 5.93e-15 Axial length; LUSC cis rs16958440 0.581 rs11875768 chr18:44689360 T/G cg17192377 chr18:44677553 HDHD2 0.52 6.12 0.32 2.6e-9 Sitting height ratio; LUSC cis rs11779988 0.503 rs411173 chr8:17768264 G/A cg01800426 chr8:17659068 MTUS1 -0.45 -5.83 -0.3 1.3e-8 Breast cancer; LUSC cis rs72781680 1.000 rs72788280 chr2:24095907 A/G cg20701182 chr2:24300061 SF3B14 0.56 6.05 0.31 3.84e-9 Lymphocyte counts; LUSC cis rs9914988 0.673 rs9890212 chr17:27169890 G/C cg09479241 chr17:27052676 TLCD1 0.43 5.93 0.31 7.51e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg24813613 chr7:1882135 MAD1L1 -0.37 -6.13 -0.32 2.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs3806843 1.000 rs3756339 chr5:140180537 A/G cg19875535 chr5:140030758 IK 0.49 8.14 0.41 7.85e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.87 -14.41 -0.62 5.82e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3892630 0.878 rs8108621 chr19:33183291 G/A cg22980127 chr19:33182716 NUDT19 0.94 12.81 0.57 8.02e-31 Red blood cell traits; LUSC cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg26597838 chr10:835615 NA 0.44 6.18 0.32 1.91e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs66887589 0.720 rs2036858 chr4:120249237 A/C cg09307838 chr4:120376055 NA 0.53 8.0 0.4 2.13e-14 Diastolic blood pressure; LUSC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg02931644 chr1:25747376 RHCE 0.32 5.79 0.3 1.59e-8 Erythrocyte sedimentation rate; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg10253022 chr22:19929467 TXNRD2;COMT 0.37 6.01 0.31 4.73e-9 Mosquito bite size; LUSC cis rs9296092 0.538 rs9461875 chr6:33516644 C/T cg13560919 chr6:33536144 NA -0.82 -15.45 -0.65 5.48e-41 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs1032466 0.783 rs6572681 chr14:51117059 C/T cg26011998 chr14:51135199 SAV1 0.45 5.86 0.31 1.14e-8 Dupuytren's disease; LUSC cis rs11039100 0.850 rs34818213 chr11:5834591 C/T cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs243505 0.691 rs243484 chr7:148448655 G/T cg09806900 chr7:148480153 CUL1 -0.53 -7.04 -0.36 1.11e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3858526 0.834 rs10838993 chr11:5979221 T/C cg13902645 chr11:5959945 NA -0.62 -8.52 -0.42 5.7e-16 DNA methylation (variation); LUSC cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg04102894 chr7:1000210 NA -0.27 -6.61 -0.34 1.53e-10 Bronchopulmonary dysplasia; LUSC cis rs4664308 0.875 rs60908067 chr2:161004983 T/G cg03641300 chr2:160917029 PLA2R1 -0.67 -11.58 -0.54 2.78e-26 Idiopathic membranous nephropathy; LUSC cis rs11051970 0.679 rs2931554 chr12:32556162 G/A cg24626660 chr12:32551988 NA 0.31 5.73 0.3 2.28e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7809950 0.861 rs10264412 chr7:107183877 G/A cg23024343 chr7:107201750 COG5 -0.7 -10.17 -0.49 2.38e-21 Coronary artery disease; LUSC cis rs11864453 0.826 rs12448315 chr16:72147242 G/T cg23815491 chr16:72088622 HP 0.35 6.09 0.32 3.11e-9 Fibrinogen levels; LUSC trans rs7980799 0.653 rs10844613 chr12:33605362 A/G cg26384229 chr12:38710491 ALG10B -0.56 -8.27 -0.41 3.15e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1957429 0.520 rs72625643 chr14:65340964 C/G cg23373153 chr14:65346875 NA -0.89 -7.7 -0.39 1.53e-13 Pediatric areal bone mineral density (radius); LUSC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg19230755 chr7:65878503 NA 0.43 6.04 0.31 4.17e-9 Aortic root size; LUSC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg24250549 chr1:154909240 PMVK 0.66 11.05 0.52 2.07e-24 Prostate cancer; LUSC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.837 rs2892296 chr12:37969785 C/T cg26384229 chr12:38710491 ALG10B -0.81 -13.46 -0.59 2.79e-33 Bladder cancer; LUSC cis rs61931739 0.500 rs34107854 chr12:34482333 C/A cg06521331 chr12:34319734 NA -0.41 -6.33 -0.33 7.7e-10 Morning vs. evening chronotype; LUSC cis rs806215 0.950 rs989099 chr7:127220827 A/G cg25922125 chr7:127225783 GCC1 -0.6 -7.57 -0.38 3.63e-13 Type 2 diabetes; LUSC cis rs711244 0.532 rs2540998 chr2:37255015 C/T cg14987922 chr2:37194071 STRN 0.42 5.8 0.3 1.55e-8 Mean platelet volume; LUSC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg04362960 chr10:104952993 NT5C2 -0.51 -5.96 -0.31 6.46e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34779708 0.966 rs2045918 chr10:35418517 T/G cg04310649 chr10:35416472 CREM -0.43 -6.62 -0.34 1.45e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs427941 0.562 rs6950791 chr7:101780458 C/T cg06246474 chr7:101738831 CUX1 0.38 6.11 0.32 2.76e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg11584989 chr19:19387371 SF4 0.67 7.99 0.4 2.27e-14 Bipolar disorder; LUSC trans rs5760092 0.627 rs6519489 chr22:24261846 G/A cg06437703 chr8:37914619 EIF4EBP1 0.52 6.49 0.33 3.02e-10 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs68170813 0.652 rs75136686 chr7:107180949 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg08088566 chr11:430123 ANO9 0.63 6.97 0.36 1.68e-11 Body mass index; LUSC cis rs6696846 0.777 rs6664397 chr1:205051871 C/T cg21545522 chr1:205238299 TMCC2 0.42 7.99 0.4 2.15e-14 Red blood cell count; LUSC trans rs3960554 0.529 rs1859795 chr7:75877354 A/G cg19862616 chr7:65841803 NCRNA00174 0.64 7.88 0.4 4.66e-14 Eotaxin levels; LUSC cis rs1728785 1.000 rs1645923 chr16:68581051 G/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC trans rs3749237 1.000 rs3749237 chr3:49770032 C/T cg21659725 chr3:3221576 CRBN 0.59 8.43 0.42 1.01e-15 Resting heart rate; LUSC cis rs7799006 0.593 rs12531150 chr7:2289888 C/T cg02951883 chr7:2050386 MAD1L1 -0.39 -6.58 -0.34 1.78e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg10295955 chr4:187884368 NA 1.05 22.88 0.78 2.2e-70 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg06636001 chr8:8085503 FLJ10661 -0.65 -10.45 -0.5 2.61e-22 Mood instability; LUSC cis rs1348850 0.632 rs13008857 chr2:178514468 G/A cg22681709 chr2:178499509 PDE11A -0.59 -11.79 -0.54 4.53e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4865169 1.000 rs4865169 chr4:57879792 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.38 -5.73 -0.3 2.24e-8 Breast cancer; LUSC cis rs16854884 0.586 rs11914731 chr3:143725594 A/G cg06585982 chr3:143692056 C3orf58 0.53 8.45 0.42 9.21e-16 Economic and political preferences (feminism/equality); LUSC cis rs950027 0.620 rs1145089 chr15:45652054 G/C cg21132104 chr15:45694354 SPATA5L1 0.42 6.1 0.32 2.89e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg21770322 chr7:97807741 LMTK2 0.4 7.07 0.36 9.16e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2281558 0.876 rs6115135 chr20:25279878 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.63 9.57 0.46 2.5e-19 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg24692254 chr21:30365293 RNF160 0.92 19.37 0.73 1.41e-56 Dental caries; LUSC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg17633681 chr16:88106987 BANP -0.51 -9.87 -0.48 2.56e-20 Menopause (age at onset); LUSC cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.24 0.45 3.03e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.05e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg07772605 chr3:195384752 SDHAP2 0.44 6.18 0.32 1.87e-9 Eotaxin levels; LUSC cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg11266682 chr4:10021025 SLC2A9 0.5 9.18 0.45 4.53e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10189230 0.967 rs1864460 chr2:222347655 A/C cg14652038 chr2:222343519 EPHA4 0.36 6.38 0.33 5.83e-10 Urate levels in lean individuals; LUSC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg12615879 chr12:58013172 SLC26A10 -0.27 -5.82 -0.3 1.34e-8 Multiple sclerosis; LUSC cis rs6426558 0.502 rs10916080 chr1:227232040 A/G cg10327440 chr1:227177885 CDC42BPA 0.56 7.51 0.38 5.49e-13 Neutrophil percentage of white cells; LUSC trans rs1728785 1.000 rs12925177 chr16:68569645 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.55 -7.35 -0.37 1.58e-12 Ulcerative colitis; LUSC cis rs1559088 0.948 rs9304844 chr19:33579935 G/T cg27124370 chr19:33622961 WDR88 0.58 7.63 0.39 2.56e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs826838 0.967 rs34496261 chr12:39023829 G/A cg13010199 chr12:38710504 ALG10B 0.69 11.49 0.53 5.88e-26 Heart rate; LUSC cis rs6964587 0.967 rs4729015 chr7:91561592 T/G cg01689657 chr7:91764605 CYP51A1 -0.34 -6.02 -0.31 4.56e-9 Breast cancer; LUSC cis rs9311676 0.656 rs6775710 chr3:58336201 A/G cg26110898 chr3:58419937 PDHB -0.46 -6.98 -0.36 1.62e-11 Systemic lupus erythematosus; LUSC cis rs6429082 0.764 rs2481095 chr1:235695756 T/C cg26050004 chr1:235667680 B3GALNT2 -0.57 -7.77 -0.39 9.77e-14 Adiposity; LUSC cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg12011299 chr4:100065546 ADH4 -0.71 -10.9 -0.51 7.13e-24 Alcohol dependence; LUSC cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg08645402 chr16:4508243 NA -0.48 -7.68 -0.39 1.8e-13 Schizophrenia; LUSC cis rs6700896 0.500 rs4655754 chr1:66114747 C/T cg14976592 chr1:65886160 LEPROT;LEPR -0.53 -6.38 -0.33 5.8e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1865760 1.000 rs6910174 chr6:25904414 C/T cg16482183 chr6:26056742 HIST1H1C 0.44 6.57 0.34 1.92e-10 Height; LUSC cis rs10979 1.000 rs13197332 chr6:143888095 T/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.93 -0.55 1.4e-27 Hypospadias; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg02951883 chr7:2050386 MAD1L1 0.42 7.3 0.37 2.13e-12 Bipolar disorder and schizophrenia; LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg18758796 chr5:131593413 PDLIM4 0.43 7.29 0.37 2.25e-12 Blood metabolite levels; LUSC cis rs853679 0.546 rs483143 chr6:27846744 G/C cg08798685 chr6:27730294 NA -0.64 -5.89 -0.31 9.23e-9 Depression; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18404041 chr3:52824283 ITIH1 -0.47 -8.85 -0.44 5.36e-17 Electroencephalogram traits; LUSC cis rs7267979 1.000 rs4815420 chr20:25383979 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.43 -0.33 4.32e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs2243480 1.000 rs3885839 chr7:65290403 G/T cg10756647 chr7:56101905 PSPH 0.88 8.42 0.42 1.09e-15 Diabetic kidney disease; LUSC cis rs2425143 1.000 rs6058311 chr20:34321895 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.18 -0.32 1.83e-9 Blood protein levels; LUSC cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg26384229 chr12:38710491 ALG10B 0.88 15.05 0.64 1.87e-39 Bladder cancer; LUSC cis rs754466 0.510 rs10824579 chr10:79590685 C/T cg17075019 chr10:79541650 NA -0.64 -9.99 -0.48 9.81e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.95 0.36 1.9e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs950169 0.881 rs34117475 chr15:85108443 T/C cg17173187 chr15:85201210 NMB 0.36 6.51 0.34 2.83e-10 Schizophrenia; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg18632100 chr19:59028615 ZBTB45 -0.66 -6.02 -0.31 4.62e-9 Myocardial infarction; LUSC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg22800045 chr5:56110881 MAP3K1 0.58 7.94 0.4 3.11e-14 Coronary artery disease; LUSC cis rs3806843 0.966 rs2563264 chr5:140137503 T/G cg19875535 chr5:140030758 IK -0.47 -7.7 -0.39 1.54e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -5.97 -0.31 6.03e-9 Developmental language disorder (linguistic errors); LUSC trans rs7618501 0.633 rs4688690 chr3:50022292 G/A cg21659725 chr3:3221576 CRBN 0.62 10.21 0.49 1.78e-21 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.67 -0.3 3.17e-8 Life satisfaction; LUSC cis rs35146811 0.695 rs1623264 chr7:99811204 G/C cg13334819 chr7:99746414 C7orf59 0.52 6.96 0.36 1.76e-11 Coronary artery disease; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg08859206 chr1:53392774 SCP2 -0.55 -9.61 -0.47 1.81e-19 Monocyte count; LUSC cis rs13040088 1.000 rs12480870 chr20:61543606 A/C cg23096297 chr20:61557774 DIDO1 0.85 11.39 0.53 1.3e-25 Menopause (age at onset); LUSC trans rs17685 0.753 rs3757593 chr7:75678735 G/A cg19862616 chr7:65841803 NCRNA00174 -1.13 -20.08 -0.74 2.19e-59 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1048238 0.506 rs848212 chr1:16263452 A/G cg21385522 chr1:16154831 NA -0.54 -8.6 -0.43 3.14e-16 Systolic blood pressure; LUSC cis rs12986413 0.967 rs4807211 chr19:2174643 G/A cg09261902 chr19:2140048 AP3D1 0.31 5.93 0.31 7.51e-9 Height; LUSC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg13206674 chr6:150067644 NUP43 0.56 8.73 0.43 1.21e-16 Lung cancer; LUSC cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7980799 0.682 rs10161491 chr12:33623806 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.4 -0.33 5.18e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg07870213 chr5:140052090 DND1 -0.75 -11.11 -0.52 1.26e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7107174 0.792 rs10899488 chr11:78088754 A/G cg02023728 chr11:77925099 USP35 0.45 6.54 0.34 2.32e-10 Testicular germ cell tumor; LUSC cis rs4423214 1.000 rs1981412 chr11:71138710 T/C cg05163923 chr11:71159392 DHCR7 0.66 9.73 0.47 7.55e-20 Vitamin D levels; LUSC trans rs629535 0.590 rs56200825 chr8:70123450 G/A cg21567404 chr3:27674614 NA -0.92 -13.31 -0.59 9.85e-33 Dupuytren's disease; LUSC cis rs11676348 0.808 rs61700947 chr2:219046171 C/G cg06547715 chr2:218990976 CXCR2 -0.32 -6.12 -0.32 2.57e-9 Ulcerative colitis; LUSC cis rs7712401 0.601 rs34348084 chr5:122335114 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.22 -0.45 3.4e-18 Mean platelet volume; LUSC trans rs1005277 0.579 rs2474574 chr10:38387295 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.87e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3741798 1.000 rs61922025 chr12:12486263 G/A cg08615371 chr12:12503544 MANSC1 1.07 10.74 0.51 2.7e-23 Cerebrospinal fluid biomarker levels; LUSC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg05425664 chr17:57184151 TRIM37 -0.53 -7.82 -0.39 6.86e-14 Intelligence (multi-trait analysis); LUSC cis rs1507153 0.651 rs9350781 chr6:79481815 A/T cg05283184 chr6:79620031 NA -0.43 -7.55 -0.38 4.11e-13 Sjögren's syndrome; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg13395646 chr4:1353034 KIAA1530 -0.62 -10.04 -0.48 6.69e-21 Obesity-related traits; LUSC cis rs1559088 0.948 rs6510346 chr19:33598526 T/A cg03563238 chr19:33554763 RHPN2 -0.4 -6.47 -0.33 3.5e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1568889 1.000 rs10767693 chr11:28093926 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.66 0.57 2.85e-30 Bipolar disorder; LUSC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 0.817 rs1705754 chr12:34145569 A/G cg26384229 chr12:38710491 ALG10B 0.56 8.97 0.44 2.14e-17 Morning vs. evening chronotype; LUSC cis rs12545109 1.000 rs1975284 chr8:57314663 A/G cg09654669 chr8:57350985 NA -0.51 -6.75 -0.35 6.48e-11 Obesity-related traits; LUSC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg01416388 chr22:39784598 NA -0.44 -7.2 -0.37 3.95e-12 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.875 rs1788176 chr8:101332112 A/G cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg07092213 chr7:1199455 ZFAND2A -0.43 -6.61 -0.34 1.51e-10 Longevity;Endometriosis; LUSC cis rs17030434 1.000 rs75418383 chr4:154719084 A/G cg14289246 chr4:154710475 SFRP2 -0.53 -6.84 -0.35 3.69e-11 Electrocardiographic conduction measures; LUSC cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg10523860 chr14:103875565 MARK3 -0.38 -6.15 -0.32 2.24e-9 Body mass index; LUSC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs62238980 0.614 rs117486425 chr22:32441850 A/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs6121246 0.821 rs3181073 chr20:30307199 A/C cg18721089 chr20:30220636 NA 0.34 5.92 0.31 7.87e-9 Mean corpuscular hemoglobin; LUSC cis rs983392 0.667 rs624663 chr11:59945065 C/T cg24026212 chr11:59952134 MS4A6A 0.34 6.03 0.31 4.27e-9 Alzheimer's disease (late onset); LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg04944784 chr2:26401820 FAM59B 0.79 11.29 0.53 2.95e-25 Gut microbiome composition (summer); LUSC cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg12219531 chr12:120966889 COQ5 0.61 8.11 0.41 9.99e-15 High light scatter reticulocyte count; LUSC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.52 -0.46 3.59e-19 Chronic sinus infection; LUSC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs6469656 0.803 rs4472547 chr8:117683846 C/T cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg00033643 chr7:134001901 SLC35B4 0.45 7.11 0.36 7.22e-12 Mean platelet volume; LUSC cis rs6982240 0.514 rs9324543 chr8:142275662 T/C cg27411547 chr8:142287226 NA -0.47 -8.02 -0.4 1.77e-14 Tonsillectomy; LUSC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg21862992 chr11:68658383 NA 0.51 7.84 0.39 6.16e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg13939156 chr17:80058883 NA -0.32 -6.38 -0.33 5.99e-10 Life satisfaction; LUSC cis rs854765 0.624 rs9902941 chr17:17733760 C/T cg09796270 chr17:17721594 SREBF1 -0.44 -7.71 -0.39 1.43e-13 Total body bone mineral density; LUSC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.62 7.92 0.4 3.55e-14 Schizophrenia; LUSC trans rs12310956 0.510 rs10129020 chr12:33858936 T/G cg26384229 chr12:38710491 ALG10B 0.54 8.25 0.41 3.61e-15 Morning vs. evening chronotype; LUSC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg04315214 chr1:2043799 PRKCZ -0.36 -7.08 -0.36 8.34e-12 Height; LUSC cis rs765787 0.530 rs2413784 chr15:45530516 A/C cg25801113 chr15:45476975 SHF 0.35 7.27 0.37 2.49e-12 Uric acid levels; LUSC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg08798685 chr6:27730294 NA -0.68 -6.14 -0.32 2.38e-9 Depression; LUSC cis rs4851254 0.660 rs59447631 chr2:100691493 T/C cg07810366 chr2:100720526 AFF3 -0.45 -6.01 -0.31 4.74e-9 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg01879757 chr17:41196368 BRCA1 -0.45 -6.99 -0.36 1.54e-11 Menopause (age at onset); LUSC cis rs3741151 0.773 rs11235770 chr11:73184002 C/T cg17517138 chr11:73019481 ARHGEF17 0.83 7.6 0.38 2.94e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs72781680 0.898 rs72796171 chr2:23942667 G/C cg08917208 chr2:24149416 ATAD2B 0.88 9.59 0.46 2.06e-19 Lymphocyte counts; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01921777 chr1:40839564 SMAP2 -0.38 -6.11 -0.32 2.84e-9 Electrocardiographic conduction measures; LUSC cis rs1832871 0.655 rs4273715 chr6:158722847 T/C cg07165851 chr6:158734300 TULP4 0.5 7.76 0.39 1.03e-13 Height; LUSC trans rs71435601 0.628 rs34125138 chr2:21418756 A/G cg20757404 chr19:378427 NA -0.41 -6.33 -0.33 8.06e-10 Cholesterol, total; LUSC cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.84 -0.3 1.27e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4919087 0.962 rs10748694 chr10:99056190 A/T cg25902810 chr10:99078978 FRAT1 0.47 6.65 0.34 1.22e-10 Monocyte count; LUSC cis rs2235649 0.663 rs113908028 chr16:1848915 G/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -5.96 -0.31 6.24e-9 Blood metabolite levels; LUSC cis rs76878669 0.561 rs12794121 chr11:66126169 G/T cg18002602 chr11:66138449 SLC29A2 0.45 8.12 0.41 8.95e-15 Educational attainment (years of education); LUSC cis rs72781680 1.000 rs17762782 chr2:24126493 A/G cg20701182 chr2:24300061 SF3B14 0.57 6.17 0.32 1.99e-9 Lymphocyte counts; LUSC trans rs800082 0.516 rs1527237 chr3:144230196 G/A cg24215973 chr2:240111563 HDAC4 0.45 6.79 0.35 5.21e-11 Smoking behavior; LUSC cis rs2307022 0.586 rs3785125 chr16:68388392 T/A cg02226672 chr16:68398533 SMPD3 0.3 5.68 0.3 2.95e-8 Body mass index; LUSC cis rs4834770 0.792 rs7676969 chr4:120173724 C/T cg24375607 chr4:120327624 NA 0.42 5.82 0.3 1.39e-8 Blood protein levels; LUSC trans rs9329221 0.507 rs12678938 chr8:10016969 C/T cg15556689 chr8:8085844 FLJ10661 -0.58 -8.67 -0.43 1.97e-16 Neuroticism; LUSC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.63 6.19 0.32 1.77e-9 Cerebrospinal P-tau181p levels; LUSC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg25427524 chr10:38739819 LOC399744 -0.58 -10.28 -0.49 1.02e-21 Extrinsic epigenetic age acceleration; LUSC cis rs11229555 0.645 rs12294062 chr11:58175603 G/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9296092 0.538 rs9469486 chr6:33516849 G/A cg13560919 chr6:33536144 NA -0.82 -15.73 -0.65 4.02e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs3749237 1.000 rs11717256 chr3:49868520 C/T cg05072774 chr3:49840536 C3orf54 -0.43 -5.96 -0.31 6.27e-9 Resting heart rate; LUSC cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg16586182 chr3:47516702 SCAP -0.54 -8.61 -0.43 2.97e-16 Colorectal cancer; LUSC cis rs7264396 0.790 rs6121026 chr20:34266883 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.57 -0.46 2.57e-19 Total cholesterol levels; LUSC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg12963246 chr6:28129442 ZNF389 0.43 5.83 0.3 1.27e-8 Depression; LUSC cis rs3772130 1.000 rs62268732 chr3:121370455 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.68 9.97 0.48 1.13e-20 Cognitive performance; LUSC cis rs2573652 0.755 rs6598286 chr15:100515985 G/T cg09918751 chr15:100517450 ADAMTS17 -0.57 -11.07 -0.52 1.85e-24 Height; LUSC cis rs1018836 0.663 rs12674903 chr8:91475774 T/C cg16814680 chr8:91681699 NA -0.64 -9.77 -0.47 5.22e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs78707713 0.560 rs2394563 chr10:71238618 G/A cg12610070 chr10:71211762 TSPAN15 -0.49 -9.6 -0.47 1.96e-19 Venous thromboembolism; LUSC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg11214544 chr1:2391121 NA -0.6 -9.69 -0.47 9.71e-20 Non-obstructive azoospermia; LUSC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg04362960 chr10:104952993 NT5C2 0.56 8.7 0.43 1.51e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9303401 0.659 rs62083436 chr17:57031742 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.1 0.58 6.35e-32 Cognitive test performance; LUSC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg06481639 chr22:41940642 POLR3H 0.51 5.93 0.31 7.37e-9 Vitiligo; LUSC cis rs7580658 0.963 rs62157555 chr2:128107176 C/T cg09760422 chr2:128146352 NA -0.33 -7.25 -0.37 2.91e-12 Protein C levels; LUSC cis rs908922 0.676 rs486283 chr1:152525957 A/G cg20991723 chr1:152506922 NA 0.49 9.23 0.45 3.09e-18 Hair morphology; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg14196790 chr5:131705035 SLC22A5 0.43 7.18 0.37 4.66e-12 Blood metabolite levels; LUSC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.5 -9.69 -0.47 1.01e-19 Monocyte percentage of white cells; LUSC cis rs6831352 0.879 rs4699716 chr4:100066125 G/A cg13256891 chr4:100009986 ADH5 -0.49 -6.37 -0.33 6.11e-10 Alcohol dependence; LUSC cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg24596788 chr1:163392923 NA -0.44 -7.46 -0.38 7.41e-13 Motion sickness; LUSC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg03644281 chr6:41068752 NFYA;LOC221442 0.47 6.93 0.35 2.22e-11 Alzheimer's disease (late onset); LUSC cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg01657329 chr11:68192670 LRP5 -0.44 -6.56 -0.34 2.02e-10 Total body bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21056992 chr19:17392414 ANKLE1 0.7 6.3 0.33 9.45e-10 Cognitive performance; LUSC cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg12863693 chr15:85201151 NMB 0.38 8.02 0.4 1.82e-14 Schizophrenia; LUSC cis rs6459788 0.692 rs10807645 chr7:157258979 T/C cg06271696 chr7:157225062 NA 0.4 6.99 0.36 1.48e-11 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs7568458 0.905 rs59877521 chr2:85759494 C/T cg23752985 chr2:85803571 VAMP8 0.34 7.32 0.37 1.91e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2835872 0.758 rs7278101 chr21:39035873 T/C cg20424643 chr21:39039972 KCNJ6 0.45 7.3 0.37 2.09e-12 Electroencephalographic traits in alcoholism; LUSC cis rs7937682 1.000 rs7128353 chr11:111538875 A/G cg19812747 chr11:111475976 SIK2 -0.43 -6.07 -0.32 3.43e-9 Primary sclerosing cholangitis; LUSC trans rs11098499 0.954 rs12508504 chr4:120410607 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.56 0.34 2.06e-10 Corneal astigmatism; LUSC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg04414720 chr1:150670196 GOLPH3L 0.55 8.99 0.44 1.82e-17 Tonsillectomy; LUSC cis rs9486719 1.000 rs13208422 chr6:96892119 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs68170813 0.559 rs2395881 chr7:107074323 A/C cg02696742 chr7:106810147 HBP1 -0.65 -9.23 -0.45 3.31e-18 Coronary artery disease; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.09 0.4 1.15e-14 Prudent dietary pattern; LUSC cis rs208520 0.690 rs12198745 chr6:66722598 T/C cg07460842 chr6:66804631 NA 1.08 16.83 0.68 1.78e-46 Exhaled nitric oxide output; LUSC cis rs9467773 0.549 rs9467805 chr6:26583366 C/T cg11502198 chr6:26597334 ABT1 0.73 11.92 0.55 1.52e-27 Intelligence (multi-trait analysis); LUSC cis rs1865760 0.827 rs9461227 chr6:25960815 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 6.85 0.35 3.49e-11 Height; LUSC cis rs1371867 0.775 rs6511 chr8:101252680 T/C cg00191853 chr8:101177733 SPAG1 0.35 5.8 0.3 1.5e-8 Atrioventricular conduction; LUSC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg26695010 chr11:65641043 EFEMP2 -0.47 -7.1 -0.36 7.44e-12 Eosinophil percentage of white cells; LUSC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg26513180 chr16:89883248 FANCA -0.61 -10.0 -0.48 9.43e-21 Vitiligo; LUSC trans rs72674100 1.000 rs12386408 chr4:97977807 T/A cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6503525 0.701 rs28618095 chr17:38109075 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -9.11 -0.45 7.8e-18 Asthma; LUSC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg24503407 chr1:205819492 PM20D1 0.43 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs8028313 0.630 rs28418298 chr15:67935745 C/T cg24579218 chr15:68104479 NA -0.37 -6.46 -0.33 3.68e-10 Obesity; LUSC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -12.09 -0.55 3.73e-28 Extrinsic epigenetic age acceleration; LUSC cis rs7113850 0.541 rs7118538 chr11:24223615 C/T ch.11.24196551F chr11:24239977 NA 0.99 9.06 0.44 1.09e-17 Bone fracture in osteoporosis; LUSC cis rs6565180 1.000 rs8049108 chr16:30376486 A/G cg17640201 chr16:30407289 ZNF48 -0.87 -15.65 -0.65 8.26e-42 Tonsillectomy; LUSC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.33 0.59 8.66e-33 Monocyte percentage of white cells; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.46 0.46 5.6e-19 Prudent dietary pattern; LUSC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg24110177 chr3:50126178 RBM5 -0.55 -8.98 -0.44 2.05e-17 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13510114 chr14:64971263 ZBTB25;ZBTB1 -0.5 -6.09 -0.32 3.18e-9 Bipolar disorder and schizophrenia; LUSC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.01 -0.48 8.51e-21 Platelet count; LUSC cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg26384229 chr12:38710491 ALG10B 0.88 15.04 0.64 2.2e-39 Bladder cancer; LUSC cis rs778371 0.722 rs2102788 chr2:233805812 G/A cg08000102 chr2:233561755 GIGYF2 0.52 6.92 0.35 2.27e-11 Schizophrenia; LUSC cis rs6582630 0.504 rs4882367 chr12:38330878 A/T cg13010199 chr12:38710504 ALG10B -0.44 -6.49 -0.33 3.02e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6977940 0.818 rs11772176 chr7:2894941 G/A cg19731401 chr7:2775893 GNA12 0.68 7.53 0.38 4.83e-13 White matter integrity; LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg14092988 chr3:52407081 DNAH1 0.31 5.97 0.31 5.92e-9 Bipolar disorder; LUSC cis rs35883536 0.647 rs2783702 chr1:101040836 G/A cg09408571 chr1:101003634 GPR88 0.29 5.67 0.3 3.12e-8 Monocyte count; LUSC trans rs561341 0.941 rs112569713 chr17:30271738 C/T cg20587970 chr11:113659929 NA -1.11 -15.3 -0.64 1.99e-40 Hip circumference adjusted for BMI; LUSC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg27286337 chr10:134555280 INPP5A 0.92 11.97 0.55 1.05e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg06850241 chr22:41845214 NA -0.3 -5.77 -0.3 1.82e-8 Vitiligo; LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg00106254 chr7:1943704 MAD1L1 0.42 6.09 0.32 3.19e-9 Bipolar disorder and schizophrenia; LUSC cis rs240764 0.717 rs6916468 chr6:101160325 G/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.08 -0.32 3.22e-9 Neuroticism; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg06074332 chr11:111473729 SIK2 0.41 6.54 0.34 2.33e-10 Mosquito bite size; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19223541 chr18:21033234 RIOK3 0.69 5.97 0.31 6.07e-9 Cognitive performance; LUSC cis rs4654899 0.802 rs17410008 chr1:21220701 G/C cg02927042 chr1:21476669 EIF4G3 -0.36 -5.66 -0.3 3.2e-8 Superior frontal gyrus grey matter volume; LUSC cis rs865483 0.929 rs853214 chr17:35860964 T/C cg06716730 chr17:35851459 DUSP14 0.28 6.33 0.33 8.12e-10 Monocyte count; LUSC cis rs2354432 0.556 rs6593777 chr1:146884013 C/G cg25205988 chr1:146714368 CHD1L 0.85 7.33 0.37 1.73e-12 Mitochondrial DNA levels; LUSC cis rs7223966 1.000 rs6504182 chr17:61823672 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.69 0.39 1.7e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6740322 0.895 rs10210125 chr2:43556433 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.56 -7.75 -0.39 1.09e-13 Coronary artery disease; LUSC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg08270630 chr22:50330655 NA -0.39 -5.89 -0.31 9.67e-9 Schizophrenia; LUSC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs11039131 0.929 rs1685404 chr11:47243665 C/G cg20307385 chr11:47447363 PSMC3 -0.53 -6.72 -0.35 7.67e-11 Schizophrenia; LUSC cis rs2742234 0.910 rs2505513 chr10:43633537 C/G cg02780029 chr10:43622663 RET -0.35 -6.7 -0.34 8.96e-11 Hirschsprung disease; LUSC cis rs7829975 0.577 rs7816329 chr8:8543843 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.68 -0.34 9.74e-11 Mood instability; LUSC cis rs3741151 0.773 rs113465107 chr11:73210416 T/G cg17517138 chr11:73019481 ARHGEF17 0.96 8.24 0.41 3.97e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs3755132 0.929 rs7594392 chr2:15750852 A/G cg12888861 chr2:15731646 DDX1 0.52 7.48 0.38 6.45e-13 Wilms tumor; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.34 0.37 1.59e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2762353 0.935 rs1165209 chr6:25801319 G/A cg12310025 chr6:25882481 NA -0.43 -7.4 -0.38 1.12e-12 Blood metabolite levels; LUSC cis rs9341808 0.714 rs4256394 chr6:80882142 C/T cg08355045 chr6:80787529 NA 0.44 7.67 0.39 1.93e-13 Sitting height ratio; LUSC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg09323728 chr8:95962352 TP53INP1 -0.41 -8.71 -0.43 1.41e-16 Type 2 diabetes; LUSC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg01879757 chr17:41196368 BRCA1 0.48 7.82 0.39 6.99e-14 Menopause (age at onset); LUSC cis rs41271473 0.750 rs17352829 chr1:228889664 A/G cg16512390 chr1:228756714 NA 0.48 5.68 0.3 2.99e-8 Chronic lymphocytic leukemia; LUSC cis rs308403 0.509 rs309382 chr4:123669772 T/C cg10495464 chr4:123653540 BBS12;LOC729338 0.98 18.67 0.71 8.5e-54 Blood protein levels; LUSC cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg17845761 chr1:175162550 KIAA0040 -0.31 -5.95 -0.31 6.59e-9 Alcohol dependence; LUSC cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg06640241 chr16:89574553 SPG7 0.72 11.64 0.54 1.58e-26 Multiple myeloma (IgH translocation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08107767 chr7:56019574 MRPS17 -0.41 -6.08 -0.32 3.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg12257692 chr3:49977190 RBM6 0.25 7.12 0.36 6.71e-12 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg26513180 chr16:89883248 FANCA -0.58 -9.45 -0.46 5.96e-19 Vitiligo; LUSC trans rs11039798 0.698 rs76315297 chr11:48240475 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.48 0.33 3.28e-10 Axial length; LUSC cis rs10986311 0.775 rs1984001 chr9:127137801 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.45 7.23 0.37 3.22e-12 Vitiligo; LUSC trans rs561341 1.000 rs7216102 chr17:30259450 A/G cg27661571 chr11:113659931 NA -0.53 -6.56 -0.34 2.07e-10 Hip circumference adjusted for BMI; LUSC cis rs988712 0.705 rs4923457 chr11:27648580 A/T cg10635145 chr11:27742435 BDNF -0.46 -5.97 -0.31 6.2e-9 Obesity; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg22963979 chr7:1858916 MAD1L1 -0.74 -12.57 -0.57 6.08e-30 Bipolar disorder and schizophrenia; LUSC cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg14458575 chr2:238380390 NA -0.71 -12.32 -0.56 5.09e-29 Prostate cancer; LUSC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11890956 chr21:40555474 PSMG1 1.04 20.99 0.75 5.49e-63 Cognitive function; LUSC cis rs778371 0.578 rs2675956 chr2:233753340 G/A cg08000102 chr2:233561755 GIGYF2 -0.63 -9.47 -0.46 5.34e-19 Schizophrenia; LUSC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg00745463 chr17:30367425 LRRC37B 0.72 8.56 0.42 4.06e-16 Hip circumference adjusted for BMI; LUSC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg16447950 chr5:562315 NA -0.57 -6.87 -0.35 3.21e-11 Lung disease severity in cystic fibrosis; LUSC cis rs12893668 0.703 rs34186780 chr14:104027595 T/G cg08213375 chr14:104286397 PPP1R13B 0.36 5.86 0.31 1.11e-8 Reticulocyte count; LUSC cis rs1348850 0.567 rs3821006 chr2:178537694 G/A cg22681709 chr2:178499509 PDE11A -0.55 -11.03 -0.52 2.5300000000000002e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg04511125 chr2:88470314 THNSL2 0.63 6.41 0.33 4.94e-10 Plasma clusterin levels; LUSC trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg03929089 chr4:120376271 NA -0.89 -13.59 -0.6 9.03e-34 Height; LUSC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -8.4 -0.42 1.29e-15 Alzheimer's disease; LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg16362232 chr11:430036 ANO9 0.6 7.9 0.4 3.97e-14 Body mass index; LUSC cis rs6977660 1.000 rs7779902 chr7:19803491 G/A cg05791153 chr7:19748676 TWISTNB 0.55 6.12 0.32 2.6e-9 Thyroid stimulating hormone; LUSC cis rs11098499 0.818 rs7688802 chr4:120451668 G/A cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC cis rs7937682 0.855 rs7109592 chr11:111533105 C/A cg19812747 chr11:111475976 SIK2 -0.49 -6.99 -0.36 1.48e-11 Primary sclerosing cholangitis; LUSC cis rs713477 0.505 rs10131672 chr14:55905091 A/T cg13175173 chr14:55914753 NA -0.31 -5.89 -0.31 9.22e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg24642439 chr20:33292090 TP53INP2 -0.49 -7.32 -0.37 1.82e-12 Glomerular filtration rate (creatinine); LUSC trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg03929089 chr4:120376271 NA -0.75 -9.24 -0.45 2.86e-18 Coronary artery disease; LUSC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg23630131 chr7:65973040 NA 0.2 5.73 0.3 2.29e-8 Aortic root size; LUSC cis rs11122272 0.735 rs2250734 chr1:231485958 G/A cg06096015 chr1:231504339 EGLN1 0.54 9.38 0.46 1.02e-18 Hemoglobin concentration; LUSC cis rs1335645 0.570 rs10494126 chr1:111671707 A/C cg00321911 chr1:111669324 DRAM2 0.63 6.79 0.35 5.05e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2832077 0.883 rs35672956 chr21:30189042 T/C cg08807101 chr21:30365312 RNF160 -0.53 -6.68 -0.34 9.85e-11 Cognitive test performance; LUSC cis rs6940638 0.606 rs6456771 chr6:27232395 G/A cg05738196 chr6:26577821 NA -0.51 -6.86 -0.35 3.3e-11 Intelligence (multi-trait analysis); LUSC cis rs72700829 0.507 rs11204766 chr1:151018060 G/C cg11822372 chr1:151115635 SEMA6C -0.77 -7.02 -0.36 1.26e-11 Schizophrenia; LUSC cis rs1801251 1.000 rs1044480 chr2:233633736 A/G cg08000102 chr2:233561755 GIGYF2 0.7 11.73 0.54 7.36e-27 Coronary artery disease; LUSC cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.46 -0.42 8.29e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg21724239 chr8:58056113 NA 0.79 9.59 0.46 2.07e-19 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg25428297 chr7:1022841 CYP2W1 0.3 6.25 0.32 1.22e-9 Longevity;Endometriosis; LUSC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg00701064 chr4:6280414 WFS1 -0.52 -11.54 -0.53 3.63e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.73 0.54 7.78e-27 Prudent dietary pattern; LUSC cis rs17253792 0.822 rs8009608 chr14:56062590 C/T cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs7523273 0.606 rs761275 chr1:207972154 A/C cg22525895 chr1:207977042 MIR29B2 -0.38 -6.12 -0.32 2.67e-9 Schizophrenia; LUSC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg08219700 chr8:58056026 NA 0.65 7.21 0.37 3.67e-12 Developmental language disorder (linguistic errors); LUSC cis rs4400599 0.618 rs1194580 chr1:154219485 G/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.39 -6.41 -0.33 4.86e-10 Platelet distribution width; LUSC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg19729930 chr2:74357872 NA 0.89 16.91 0.68 8.97e-47 Gestational age at birth (maternal effect); LUSC cis rs7254114 0.578 rs35248735 chr19:11312238 G/A cg02815516 chr19:11306319 KANK2 -0.41 -8.62 -0.43 2.81e-16 Immature fraction of reticulocytes; LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg22764044 chr5:178986830 RUFY1 -0.57 -9.57 -0.46 2.44e-19 Lung cancer; LUSC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg02018176 chr4:1364513 KIAA1530 0.49 8.41 0.42 1.18e-15 Obesity-related traits; LUSC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg17971929 chr21:40555470 PSMG1 0.79 13.71 0.6 3.07e-34 Cognitive function; LUSC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg05585544 chr11:47624801 NA -0.42 -7.4 -0.38 1.11e-12 Subjective well-being; LUSC cis rs2795502 1.000 rs2142991 chr10:43341105 C/T cg27426351 chr10:43362370 NA -0.43 -5.92 -0.31 8.17e-9 Blood protein levels; LUSC cis rs7523273 0.526 rs1204708 chr1:208024062 G/C cg22525895 chr1:207977042 MIR29B2 -0.38 -6.13 -0.32 2.48e-9 Schizophrenia; LUSC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.73 0.43 1.22e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs9473147 0.516 rs1931837 chr6:47442377 C/T cg12968598 chr6:47444699 CD2AP 0.54 8.07 0.4 1.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.9e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs61931739 0.635 rs10743836 chr12:33961680 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.62 0.38 2.61e-13 Morning vs. evening chronotype; LUSC cis rs7100689 0.646 rs2994390 chr10:82074395 C/A cg01528321 chr10:82214614 TSPAN14 0.83 12.55 0.57 7.61e-30 Post bronchodilator FEV1; LUSC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg05132306 chr1:1846340 CALML6 -0.24 -5.8 -0.3 1.54e-8 Body mass index; LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg20203395 chr5:56204925 C5orf35 -0.81 -10.71 -0.51 3.32e-23 Initial pursuit acceleration; LUSC cis rs7590368 0.651 rs56093996 chr2:10931302 T/C cg15705551 chr2:10952987 PDIA6 0.52 5.86 0.31 1.13e-8 Educational attainment (years of education); LUSC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg09165964 chr15:75287851 SCAMP5 0.54 7.84 0.39 6.21e-14 Breast cancer; LUSC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg12463550 chr7:65579703 CRCP 0.52 7.54 0.38 4.36e-13 Aortic root size; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg07092213 chr7:1199455 ZFAND2A -0.55 -8.44 -0.42 9.99e-16 Longevity;Endometriosis; LUSC cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg22782873 chr19:19639568 YJEFN3 -0.47 -5.82 -0.3 1.35e-8 Bipolar disorder; LUSC cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg27129171 chr3:47204927 SETD2 0.7 11.83 0.54 3.24e-27 Colorectal cancer; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg27284194 chr4:1044797 NA 0.37 6.03 0.31 4.46e-9 Longevity; LUSC cis rs17253792 0.749 rs45458197 chr14:56145018 A/T cg01858014 chr14:56050164 KTN1 -0.79 -6.72 -0.35 7.8e-11 Putamen volume; LUSC trans rs2587949 0.615 rs2166023 chr3:4211752 C/T cg15139668 chr4:4577005 NA 0.41 6.08 0.32 3.23e-9 Periodontitis (DPAL); LUSC cis rs9311676 0.586 rs73085867 chr3:58434791 C/T cg26110898 chr3:58419937 PDHB 0.41 6.68 0.34 1.02e-10 Systemic lupus erythematosus; LUSC cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg18404041 chr3:52824283 ITIH1 0.4 7.2 0.37 3.96e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg16325326 chr1:53192061 ZYG11B 0.96 18.33 0.71 2e-52 Monocyte count; LUSC trans rs11039798 1.000 rs10838942 chr11:48557163 C/G cg15704280 chr7:45808275 SEPT13 0.69 6.56 0.34 2.06e-10 Axial length; LUSC cis rs9473147 0.516 rs2151974 chr6:47515630 G/A cg02130027 chr6:47444894 CD2AP 0.36 5.74 0.3 2.09e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg11189052 chr15:85197271 WDR73 -0.46 -5.66 -0.3 3.34e-8 Schizophrenia; LUSC cis rs9640161 0.830 rs3757424 chr7:150067679 C/A cg10018233 chr7:150070692 REPIN1 0.46 9.38 0.46 1.06e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs9311676 0.656 rs4339119 chr3:58389462 A/G cg13750441 chr3:58318267 PXK 0.35 6.72 0.35 7.86e-11 Systemic lupus erythematosus; LUSC cis rs8017423 0.647 rs11623736 chr14:90746471 G/T cg14092571 chr14:90743983 NA 0.35 5.67 0.3 3.07e-8 Mortality in heart failure; LUSC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); LUSC cis rs3862260 0.905 rs3850870 chr1:120161037 C/T cg16322792 chr1:120165303 ZNF697 0.5 9.59 0.46 2.2e-19 Systemic lupus erythematosus; LUSC cis rs6121246 0.609 rs6089075 chr20:30392884 A/G cg13852791 chr20:30311386 BCL2L1 0.93 14.05 0.61 1.47e-35 Mean corpuscular hemoglobin; LUSC cis rs73206853 0.764 rs16940909 chr12:111054591 G/C cg12870014 chr12:110450643 ANKRD13A 0.7 7.81 0.39 7.23e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg20587970 chr11:113659929 NA 1.23 12.71 0.57 1.86e-30 Hip circumference adjusted for BMI; LUSC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg21033440 chr11:65409861 SIPA1 -0.52 -7.17 -0.37 4.76e-12 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs7264396 0.887 rs736032 chr20:34048661 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.72 -0.35 7.94e-11 Total cholesterol levels; LUSC cis rs10489525 0.599 rs910622 chr1:115600424 A/G cg17147537 chr1:115611705 TSPAN2 -0.29 -5.95 -0.31 6.84e-9 Autism; LUSC cis rs733592 1.000 rs733592 chr12:48429776 C/T cg24011408 chr12:48396354 COL2A1 -0.46 -7.59 -0.38 3.32e-13 Plateletcrit; LUSC cis rs2692947 0.727 rs1657502 chr2:96795608 A/C cg22654517 chr2:96458247 NA 0.36 7.24 0.37 3.08e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs3125734 0.633 rs10761616 chr10:64009076 G/A cg09941381 chr10:64027924 RTKN2 -0.39 -7.14 -0.36 5.75e-12 Rheumatoid arthritis; LUSC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg00310523 chr12:86230176 RASSF9 0.47 8.39 0.42 1.37e-15 Major depressive disorder; LUSC cis rs868036 0.718 rs8025790 chr15:68076399 G/T cg08079166 chr15:68083412 MAP2K5 0.41 7.54 0.38 4.59e-13 Restless legs syndrome; LUSC cis rs4888262 0.526 rs4888253 chr16:74583146 C/T cg01733217 chr16:74700730 RFWD3 0.75 12.29 0.56 6.92e-29 Testicular germ cell tumor; LUSC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -5.69 -0.3 2.73e-8 Major depressive disorder; LUSC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg17554472 chr22:41940697 POLR3H -0.45 -5.66 -0.3 3.31e-8 Vitiligo; LUSC cis rs61931739 0.534 rs10844828 chr12:34303109 C/T cg06521331 chr12:34319734 NA -0.51 -8.92 -0.44 3.11e-17 Morning vs. evening chronotype; LUSC cis rs11992162 0.636 rs4841646 chr8:11798707 C/G cg21775007 chr8:11205619 TDH 0.44 5.96 0.31 6.52e-9 Monocyte count; LUSC cis rs7246657 0.943 rs7255952 chr19:37988797 A/G cg23950597 chr19:37808831 NA -0.6 -7.26 -0.37 2.8e-12 Coronary artery calcification; LUSC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg25124228 chr12:125621409 AACS -0.48 -7.1 -0.36 7.77e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.84 13.03 0.58 1.12e-31 Cognitive test performance; LUSC trans rs1997103 1.000 rs10270618 chr7:55396712 T/A cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6121246 0.567 rs6120815 chr20:30184866 T/C cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs16976116 0.851 rs28889339 chr15:55503205 T/G cg11288833 chr15:55489084 RSL24D1 0.51 6.16 0.32 2.05e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6951245 0.678 rs4724725 chr7:1214751 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.96 -0.48 1.2e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4268898 0.636 rs72787371 chr2:24570073 T/A cg06627628 chr2:24431161 ITSN2 -0.86 -12.53 -0.57 8.97e-30 Asthma; LUSC cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg24209194 chr3:40518798 ZNF619 -0.44 -6.0 -0.31 5.17e-9 Renal cell carcinoma; LUSC cis rs10207060 0.500 rs6731870 chr2:240708096 C/A cg20333904 chr2:240724165 NA -0.36 -6.12 -0.32 2.56e-9 Obesity-related traits; LUSC cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg17892150 chr10:133769511 PPP2R2D -0.65 -8.73 -0.43 1.22e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg08280861 chr8:58055591 NA 0.54 6.49 0.33 3.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.908 rs56351880 chr22:50316597 A/G cg02269571 chr22:50332266 NA -0.64 -9.48 -0.46 4.8e-19 Schizophrenia; LUSC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 7.17 0.37 4.89e-12 Multiple sclerosis; LUSC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg25767906 chr1:53392781 SCP2 0.44 7.73 0.39 1.28e-13 Monocyte count; LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg11062466 chr8:58055876 NA 0.58 8.23 0.41 4.14e-15 Developmental language disorder (linguistic errors); LUSC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg14893161 chr1:205819251 PM20D1 0.46 6.14 0.32 2.29e-9 Parkinson's disease; LUSC cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.63 -0.47 1.61e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs9462027 0.628 rs9469889 chr6:34763900 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.76 -0.3 1.89e-8 Systemic lupus erythematosus; LUSC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg01448562 chr3:133502909 NA -0.6 -9.93 -0.48 1.62e-20 Iron status biomarkers; LUSC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg02221750 chr19:17393354 ANKLE1 -0.91 -13.72 -0.6 2.84e-34 Systemic lupus erythematosus; LUSC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs9811920 0.809 rs796976 chr3:99621002 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 7.54 0.38 4.55e-13 Axial length; LUSC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg19230755 chr7:65878503 NA 0.41 5.76 0.3 1.95e-8 Aortic root size; LUSC cis rs2667011 0.818 rs2667025 chr2:160839341 A/G cg06573604 chr2:160760825 LY75 0.46 5.95 0.31 6.73e-9 Bilirubin levels; LUSC cis rs12291225 0.546 rs12291662 chr11:14342949 T/C cg19336497 chr11:14380999 RRAS2 -0.61 -14.16 -0.61 5.7e-36 Sense of smell; LUSC cis rs12928939 0.911 rs11645725 chr16:71826883 C/T cg03805757 chr16:71968109 PKD1L3 -0.46 -6.65 -0.34 1.23e-10 Post bronchodilator FEV1; LUSC cis rs1797081 0.901 rs703059 chr10:16876402 G/A cg23933602 chr10:16859644 RSU1 0.99 19.98 0.74 5.76e-59 Platelet distribution width; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg16606324 chr3:10149918 C3orf24 0.63 9.48 0.46 4.89e-19 Alzheimer's disease; LUSC cis rs1577917 1.000 rs4707239 chr6:86610717 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs1448094 0.617 rs1502799 chr12:86474921 T/C cg00310523 chr12:86230176 RASSF9 -0.33 -5.97 -0.31 5.98e-9 Major depressive disorder; LUSC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg17385448 chr1:15911702 AGMAT 0.37 6.38 0.33 5.82e-10 Systolic blood pressure; LUSC cis rs1018836 0.828 rs9297870 chr8:91570691 C/G cg16814680 chr8:91681699 NA -0.71 -11.31 -0.53 2.54e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs36093844 0.898 rs895255 chr11:85534546 A/C cg25872744 chr11:85566296 CCDC83 0.44 6.48 0.33 3.2e-10 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs73206853 0.698 rs871922 chr12:111114942 T/C cg12870014 chr12:110450643 ANKRD13A 0.7 7.49 0.38 6.2800000000000005e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7084921 0.520 rs2902377 chr10:101876770 G/A cg02250046 chr10:101825185 CPN1 -0.31 -5.73 -0.3 2.25e-8 Bone mineral density; LUSC cis rs11190604 1.000 rs10883511 chr10:102299407 A/G cg07080220 chr10:102295463 HIF1AN 0.7 9.62 0.47 1.72e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1775715 0.966 rs1755067 chr10:32296195 C/T cg26784012 chr10:32216390 ARHGAP12 -0.38 -6.24 -0.32 1.36e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.39 -6.27 -0.32 1.12e-9 IgG glycosylation; LUSC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg24549020 chr5:56110836 MAP3K1 0.5 6.06 0.31 3.63e-9 Initial pursuit acceleration; LUSC cis rs1358748 0.522 rs6588241 chr1:67586913 T/C cg02640540 chr1:67518911 SLC35D1 0.63 6.08 0.32 3.31e-9 Tuberculosis; LUSC cis rs6121246 0.609 rs6060843 chr20:30297047 G/C cg13852791 chr20:30311386 BCL2L1 0.94 14.42 0.62 5.67e-37 Mean corpuscular hemoglobin; LUSC cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg24692254 chr21:30365293 RNF160 0.92 18.7 0.72 6.55e-54 Dental caries; LUSC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -6.06 -0.31 3.7e-9 Personality dimensions; LUSC cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg05283184 chr6:79620031 NA -0.57 -12.14 -0.55 2.5e-28 Intelligence (multi-trait analysis); LUSC cis rs9650315 0.866 rs35294340 chr8:57199992 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.28 0.37 2.42e-12 Height; LUSC cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -9.89 -0.48 2.14e-20 Chronic sinus infection; LUSC cis rs11971779 0.616 rs10269683 chr7:139100868 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.13 0.36 6.42e-12 Diisocyanate-induced asthma; LUSC cis rs7772486 0.875 rs2748502 chr6:146298239 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.78 -0.35 5.46e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg02951883 chr7:2050386 MAD1L1 -0.6 -10.74 -0.51 2.59e-23 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg25036284 chr2:26402008 FAM59B -0.69 -9.84 -0.47 3.24e-20 Gut microbiome composition (summer); LUSC cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg01689657 chr7:91764605 CYP51A1 -0.32 -5.77 -0.3 1.79e-8 Breast cancer; LUSC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg25036284 chr2:26402008 FAM59B 0.78 11.06 0.52 1.94e-24 Gut microbiome composition (summer); LUSC cis rs4077515 0.870 rs10781510 chr9:139279173 G/A cg14019695 chr9:139328340 INPP5E 0.45 8.17 0.41 6.4e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2580764 0.540 rs10210840 chr2:55226009 G/A cg20993754 chr2:55226987 RTN4 0.36 6.07 0.32 3.46e-9 Mean platelet volume; LUSC cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg16482183 chr6:26056742 HIST1H1C 0.55 8.21 0.41 4.78e-15 Height; LUSC cis rs6967385 0.560 rs10272105 chr7:12358122 C/A cg20607287 chr7:12443886 VWDE 0.43 6.32 0.33 8.53e-10 Response to taxane treatment (placlitaxel); LUSC cis rs9902453 0.740 rs2628189 chr17:28088813 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.24 -0.52 4.38e-25 Coffee consumption (cups per day); LUSC trans rs3733585 0.673 rs7434391 chr4:9967682 C/G cg26043149 chr18:55253948 FECH -0.46 -7.09 -0.36 7.93e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.59 -0.54 2.5e-26 Schizophrenia; LUSC cis rs11098499 0.697 rs35280960 chr4:120257059 G/A cg24375607 chr4:120327624 NA 0.77 12.24 0.56 1.04e-28 Corneal astigmatism; LUSC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.23 -0.32 1.42e-9 Developmental language disorder (linguistic errors); LUSC cis rs10887741 0.646 rs11202499 chr10:89433211 C/G cg13926569 chr10:89418898 PAPSS2 0.33 7.12 0.36 6.83e-12 Exercise (leisure time); LUSC trans rs6952808 1.000 rs4719319 chr7:1888094 G/A cg24247370 chr13:99142703 STK24 -0.33 -6.08 -0.32 3.2e-9 Bipolar disorder and schizophrenia; LUSC cis rs12908161 1.000 rs62019464 chr15:85294469 T/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.66 0.34 1.15e-10 Schizophrenia; LUSC cis rs4363385 0.643 rs11576457 chr1:152918556 C/T cg08895932 chr1:152778580 LCE1C 0.33 5.81 0.3 1.48e-8 Inflammatory skin disease; LUSC cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg22601191 chr20:60968625 CABLES2 -0.48 -6.93 -0.35 2.13e-11 Colorectal cancer; LUSC cis rs7937682 0.632 rs14133 chr11:111782697 C/G cg09085632 chr11:111637200 PPP2R1B 0.92 12.56 0.57 6.87e-30 Primary sclerosing cholangitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18013782 chr17:65240863 HELZ 0.41 6.09 0.32 3.17e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1371867 0.846 rs1660353 chr8:101250907 C/T cg00191853 chr8:101177733 SPAG1 0.35 5.84 0.3 1.25e-8 Atrioventricular conduction; LUSC cis rs2274273 0.934 rs10137307 chr14:55845185 T/C cg04306507 chr14:55594613 LGALS3 0.52 11.48 0.53 6.28e-26 Protein biomarker; LUSC cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg07061783 chr6:25882402 NA -0.38 -5.86 -0.31 1.12e-8 Blood metabolite levels; LUSC cis rs11690935 0.921 rs10200608 chr2:172597929 G/A cg13550731 chr2:172543902 DYNC1I2 -0.87 -14.38 -0.62 7.9e-37 Schizophrenia; LUSC cis rs1461503 0.512 rs4293126 chr11:122804133 A/G cg27398637 chr11:122830231 C11orf63 0.36 5.8 0.3 1.55e-8 Menarche (age at onset); LUSC cis rs2108225 0.658 rs1476673 chr7:107435945 C/G cg18560240 chr7:107437656 SLC26A3 -0.44 -6.82 -0.35 4.28e-11 Ulcerative colitis; LUSC cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg18681998 chr4:17616180 MED28 0.85 15.67 0.65 6.85e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs73200209 0.744 rs1344863 chr12:116408257 A/T cg01776926 chr12:116560359 MED13L -0.52 -5.86 -0.31 1.14e-8 Total body bone mineral density; LUSC cis rs2580764 0.678 rs2580765 chr2:55204028 A/C cg09592903 chr2:55203963 RTN4 0.48 9.92 0.48 1.64e-20 Mean platelet volume; LUSC cis rs1891275 0.515 rs1080496 chr10:93444262 C/T cg07889827 chr10:93443413 NA 0.37 8.27 0.41 3.24e-15 Intelligence (multi-trait analysis); LUSC cis rs6696846 0.691 rs11240370 chr1:205118336 T/G cg21545522 chr1:205238299 TMCC2 0.47 8.81 0.43 7.18e-17 Red blood cell count; LUSC cis rs7107174 0.901 rs10899497 chr11:78124534 T/C cg02023728 chr11:77925099 USP35 0.43 6.2 0.32 1.66e-9 Testicular germ cell tumor; LUSC cis rs9486719 0.901 rs13206547 chr6:97006942 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.98 -0.48 1.09e-20 Migraine;Coronary artery disease; LUSC cis rs1577917 0.958 rs1335442 chr6:86466692 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.13 -0.36 6.33e-12 Response to antipsychotic treatment; LUSC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg06636001 chr8:8085503 FLJ10661 0.55 8.09 0.4 1.12e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg05855489 chr10:104503620 C10orf26 -0.67 -9.79 -0.47 4.6e-20 Allergic disease (asthma, hay fever or eczema); LUSC trans rs2739330 0.703 rs5760112 chr22:24259772 C/G cg06437703 chr8:37914619 EIF4EBP1 -0.64 -10.5 -0.5 1.73e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9796 0.621 rs2928142 chr15:41470449 T/C cg18705301 chr15:41695430 NDUFAF1 0.48 8.53 0.42 5.24e-16 Menopause (age at onset); LUSC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 8.81 0.43 7e-17 Schizophrenia; LUSC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg18827107 chr12:86230957 RASSF9 -0.47 -7.06 -0.36 9.99e-12 Major depressive disorder; LUSC cis rs7267979 1.000 rs6083828 chr20:25369918 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.63 -0.34 1.33e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg17173187 chr15:85201210 NMB -0.32 -6.7 -0.34 8.67e-11 P wave terminal force; LUSC cis rs1577917 0.629 rs7761762 chr6:86205968 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.5 7.85 0.39 5.73e-14 Response to antipsychotic treatment; LUSC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs1419980 0.673 rs2377086 chr12:7753798 C/T cg10578777 chr12:7781093 NA 0.58 6.39 0.33 5.59e-10 HDL cholesterol levels; LUSC cis rs34779708 0.897 rs9665538 chr10:35461038 T/C cg04310649 chr10:35416472 CREM -0.41 -6.4 -0.33 5.33e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9300255 0.544 rs1790130 chr12:123701270 A/C cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs950169 0.686 rs12906474 chr15:85109237 A/G cg12863693 chr15:85201151 NMB 0.35 7.14 0.36 6e-12 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18838581 chr19:2269401 OAZ1 -0.41 -5.97 -0.31 5.94e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs453301 0.598 rs2921383 chr8:8892221 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.53 0.34 2.39e-10 Joint mobility (Beighton score); LUSC trans rs61931739 0.635 rs10772123 chr12:33975557 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.68 0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs295140 0.681 rs6435048 chr2:201167854 C/T cg04283868 chr2:201171347 SPATS2L 0.43 6.24 0.32 1.34e-9 QT interval; LUSC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg26380479 chr7:97908229 NA -0.28 -6.1 -0.32 2.87e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.96e-13 Obesity-related traits; LUSC cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg06784218 chr1:46089804 CCDC17 -0.48 -9.21 -0.45 3.67e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg07701084 chr6:150067640 NUP43 0.46 6.88 0.35 2.9100000000000002e-11 Lung cancer; LUSC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg06636001 chr8:8085503 FLJ10661 -0.58 -8.58 -0.43 3.5e-16 Mean corpuscular volume; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg25072359 chr17:41440525 NA 0.65 9.22 0.45 3.32e-18 Menopause (age at onset); LUSC cis rs55665837 1.000 rs11023214 chr11:14436259 G/C cg19336497 chr11:14380999 RRAS2 -0.37 -7.51 -0.38 5.34e-13 Vitamin D levels; LUSC cis rs7107174 0.892 rs11237477 chr11:78095069 A/T cg02023728 chr11:77925099 USP35 0.44 6.58 0.34 1.77e-10 Testicular germ cell tumor; LUSC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg03676636 chr4:99064102 C4orf37 0.32 6.85 0.35 3.6e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs950027 0.549 rs11636114 chr15:45601412 C/G cg26924012 chr15:45694286 SPATA5L1 0.77 11.42 0.53 1.04e-25 Response to fenofibrate (adiponectin levels); LUSC trans rs4811340 0.533 rs6068253 chr20:51180425 C/A cg15736553 chr3:11610338 VGLL4 -0.33 -5.95 -0.31 6.7e-9 Thyroid peroxidase antibody positivity; LUSC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg22166914 chr1:53195759 ZYG11B 0.57 9.35 0.46 1.33e-18 Monocyte count; LUSC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg19539972 chr4:7069911 GRPEL1 -0.7 -7.34 -0.37 1.64e-12 Monocyte percentage of white cells; LUSC cis rs314370 0.951 rs13226502 chr7:100506381 C/T cg10426581 chr7:100472382 SRRT 0.85 12.21 0.56 1.37e-28 Resting heart rate; LUSC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9398803 0.965 rs9388489 chr6:126698719 C/T cg19875578 chr6:126661172 C6orf173 -0.42 -6.24 -0.32 1.35e-9 Male-pattern baldness; LUSC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg16447950 chr5:562315 NA -0.57 -6.87 -0.35 3.21e-11 Lung disease severity in cystic fibrosis; LUSC cis rs7824557 0.564 rs7828263 chr8:11231886 A/G cg21775007 chr8:11205619 TDH -0.72 -11.35 -0.53 1.78e-25 Retinal vascular caliber; LUSC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg04267008 chr7:1944627 MAD1L1 -0.52 -7.51 -0.38 5.42e-13 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25616684 chr1:38478508 UTP11L 0.41 6.09 0.32 3.12e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13242816 1.000 rs2188243 chr7:116109293 G/A cg16553024 chr7:116138462 CAV2 -0.54 -5.92 -0.31 7.84e-9 P wave duration; LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg07424592 chr7:64974309 NA 0.66 5.82 0.3 1.38e-8 Diabetic kidney disease; LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.3 0.67 2.38e-44 Platelet count; LUSC cis rs6840360 0.642 rs56301462 chr4:152452128 T/G cg20465933 chr4:152376761 FAM160A1 0.35 6.33 0.33 8e-10 Intelligence (multi-trait analysis); LUSC cis rs6681460 0.966 rs9659879 chr1:67121434 T/C cg02459107 chr1:67143332 SGIP1 0.47 8.94 0.44 2.71e-17 Presence of antiphospholipid antibodies; LUSC cis rs7169223 0.615 rs11630027 chr15:79096983 C/A cg21242079 chr15:79101063 ADAMTS7 0.39 5.88 0.31 9.81e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg23711669 chr6:146136114 FBXO30 0.77 13.91 0.61 5.14e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs9921338 0.961 rs7206017 chr16:11440861 C/T cg00044050 chr16:11439710 C16orf75 -0.51 -6.68 -0.34 9.91e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs7833787 1.000 rs7833787 chr8:18707871 A/G cg17701159 chr8:18705777 PSD3 -0.4 -6.56 -0.34 2.11e-10 Obesity-related traits; LUSC cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg20701182 chr2:24300061 SF3B14 0.47 5.68 0.3 2.97e-8 Asthma; LUSC cis rs367615 0.918 rs10070104 chr5:108866438 C/T cg17395555 chr5:108820864 NA -0.41 -6.08 -0.32 3.31e-9 Colorectal cancer (SNP x SNP interaction); LUSC cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg19628046 chr18:33552617 C18orf21 0.51 6.29 0.33 1e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg04518342 chr5:131593106 PDLIM4 0.41 6.35 0.33 7.13e-10 Breast cancer; LUSC cis rs258324 0.790 rs8062346 chr16:89732668 G/A cg04287289 chr16:89883240 FANCA 0.69 6.13 0.32 2.48e-9 Height; LUSC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg12963246 chr6:28129442 ZNF389 0.42 6.11 0.32 2.74e-9 Depression; LUSC cis rs6547741 0.844 rs9678851 chr2:27887034 C/A cg12559939 chr2:27858050 GPN1 -0.41 -6.31 -0.33 8.82e-10 Oral cavity cancer; LUSC cis rs8072100 0.666 rs9913503 chr17:45776330 T/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.14 -0.32 2.35e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.39 0.33 5.48e-10 Menopause (age at onset); LUSC cis rs4721295 0.546 rs1637766 chr7:2204400 G/A cg04267008 chr7:1944627 MAD1L1 0.5 7.53 0.38 4.92e-13 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC trans rs57221529 0.713 rs12522724 chr5:590742 T/C cg25482853 chr8:67687455 SGK3 1.18 16.74 0.68 4.07e-46 Lung disease severity in cystic fibrosis; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg05347473 chr6:146136440 FBXO30 0.47 8.03 0.4 1.63e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467773 0.620 rs2504540 chr6:26641626 A/G cg05738196 chr6:26577821 NA 0.79 15.07 0.64 1.6e-39 Intelligence (multi-trait analysis); LUSC cis rs62027291 1.000 rs62027291 chr15:77266051 G/A cg26408565 chr15:76604113 ETFA 0.6 6.78 0.35 5.55e-11 Plateletcrit; LUSC cis rs2594714 0.538 rs895819 chr19:13947292 A/G cg18576835 chr19:13944261 NA -0.49 -7.9 -0.4 3.94e-14 Breast cancer; LUSC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg03060546 chr3:49711283 APEH 0.71 11.95 0.55 1.23e-27 Resting heart rate; LUSC cis rs1865760 0.827 rs9295680 chr6:25944103 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 7.16 0.36 5.26e-12 Height; LUSC cis rs4363385 0.574 rs4041402 chr1:152947397 T/C cg00922841 chr1:152955080 SPRR1A -0.36 -6.05 -0.31 3.85e-9 Inflammatory skin disease; LUSC cis rs6964587 1.000 rs9690208 chr7:91735613 T/A cg17063962 chr7:91808500 NA 0.59 9.29 0.45 2.06e-18 Breast cancer; LUSC cis rs2580764 0.598 rs2580772 chr2:55218805 G/T cg09592903 chr2:55203963 RTN4 0.47 9.72 0.47 8.09e-20 Mean platelet volume; LUSC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg13175981 chr1:150552382 MCL1 0.43 6.16 0.32 2.05e-9 Tonsillectomy; LUSC cis rs8114671 0.836 rs2104083 chr20:33649133 G/A cg07148914 chr20:33460835 GGT7 -0.46 -6.8 -0.35 4.88e-11 Height; LUSC cis rs66887589 0.616 rs11732621 chr4:120212883 A/C cg24375607 chr4:120327624 NA 0.5 7.56 0.38 3.95e-13 Diastolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13411897 chr3:12526166 TSEN2 -0.46 -5.99 -0.31 5.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 16.14 0.66 9.94e-44 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2607426 0.681 rs2607411 chr19:41268555 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.85 6.72 0.35 7.9e-11 Blood protein levels; LUSC cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg01884057 chr2:25150051 NA 0.48 11.28 0.53 3.09e-25 Body mass index; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.71 10.96 0.51 4.44e-24 Lymphocyte counts; LUSC cis rs6456156 0.586 rs2001115 chr6:167486218 A/C cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs7923452 0.688 rs8177029 chr10:30748498 C/T cg25182066 chr10:30743637 MAP3K8 -0.64 -5.69 -0.3 2.77e-8 Itch intensity from mosquito bite; LUSC cis rs664172 1 rs664172 chr15:78862762 G/A cg06917634 chr15:78832804 PSMA4 -0.53 -6.53 -0.34 2.44e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs4332037 0.950 rs7807014 chr7:1939021 T/C cg23422044 chr7:1970798 MAD1L1 -0.65 -7.31 -0.37 1.94e-12 Bipolar disorder; LUSC cis rs7903847 0.642 rs11814021 chr10:99158386 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.06 -0.4 1.41e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs9534288 0.619 rs6561292 chr13:46683560 G/T cg15192986 chr13:46630673 CPB2 0.75 10.91 0.51 6.43e-24 Blood protein levels; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg24449302 chr15:66679100 MAP2K1 -0.31 -6.05 -0.31 3.79e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10492096 0.947 rs11064231 chr12:6604415 T/G cg13857086 chr12:6580257 VAMP1 0.61 7.25 0.37 2.89e-12 Hip geometry; LUSC cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC trans rs8073060 0.544 rs225283 chr17:33934912 A/G cg19694781 chr19:47549865 TMEM160 -1.13 -18.17 -0.71 8.74e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg14552801 chr7:65878734 NA 0.37 5.67 0.3 3.09e-8 Aortic root size; LUSC trans rs6952808 0.782 rs4236271 chr7:1881369 C/T cg24247370 chr13:99142703 STK24 -0.33 -6.12 -0.32 2.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC trans rs2786098 0.571 rs6677361 chr1:197521877 T/C cg16005942 chr6:160526640 IGF2R -0.49 -6.07 -0.32 3.38e-9 Asthma; LUSC cis rs9296092 0.560 rs62407561 chr6:33528103 T/C cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg25036284 chr2:26402008 FAM59B 0.63 8.91 0.44 3.42e-17 Gut microbiome composition (summer); LUSC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg17724175 chr1:150552817 MCL1 -0.43 -7.66 -0.39 2.08e-13 Blood protein levels; LUSC cis rs7524258 0.868 rs6577428 chr1:7314655 C/T cg07173049 chr1:7289937 CAMTA1 -0.29 -5.78 -0.3 1.71e-8 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg13010199 chr12:38710504 ALG10B -0.58 -9.17 -0.45 5.12e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs12464483 0.524 rs2602772 chr2:30885263 C/A cg07150166 chr2:30669952 LCLAT1 0.54 6.33 0.33 7.79e-10 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs12493885 0.628 rs61790905 chr3:153653032 A/G cg17054900 chr3:154042577 DHX36 -0.54 -5.66 -0.3 3.23e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3125734 0.633 rs1873685 chr10:64032126 C/T cg19640130 chr10:64028056 RTKN2 -0.41 -7.22 -0.37 3.44e-12 Rheumatoid arthritis; LUSC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg26579491 chr7:65878976 NA 0.42 5.71 0.3 2.54e-8 Aortic root size; LUSC cis rs4478858 0.684 rs12403136 chr1:31728920 A/G cg00250761 chr1:31883323 NA -0.36 -8.46 -0.42 8.54e-16 Alcohol dependence; LUSC cis rs3771570 0.901 rs3815262 chr2:242352582 A/T cg21155796 chr2:242212141 HDLBP 0.52 6.38 0.33 5.76e-10 Prostate cancer; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg02951883 chr7:2050386 MAD1L1 0.61 11.99 0.55 8.56e-28 Bipolar disorder and schizophrenia; LUSC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg15839431 chr19:19639596 YJEFN3 -0.4 -5.69 -0.3 2.76e-8 Tonsillectomy; LUSC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg05585544 chr11:47624801 NA 0.41 7.15 0.36 5.36e-12 Subjective well-being; LUSC cis rs7709377 0.595 rs12109104 chr5:115615708 A/G cg23108291 chr5:115420582 COMMD10 0.4 5.74 0.3 2.11e-8 Metabolite levels (X-11787); LUSC cis rs9398803 0.865 rs4897181 chr6:126753564 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.13 0.32 2.53e-9 Male-pattern baldness; LUSC cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg02403541 chr12:121454288 C12orf43 0.77 12.46 0.56 1.53e-29 N-glycan levels; LUSC cis rs36093844 0.747 rs17817314 chr11:85594972 T/C cg25872744 chr11:85566296 CCDC83 -0.46 -6.04 -0.31 4.16e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg03929089 chr4:120376271 NA -0.84 -13.0 -0.58 1.48e-31 Coronary artery disease; LUSC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg11764359 chr7:65958608 NA -0.71 -10.82 -0.51 1.39e-23 Aortic root size; LUSC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.58 7.26 0.37 2.66e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09460159 chr17:30771470 PSMD11 -0.48 -6.34 -0.33 7.43e-10 Bipolar disorder and schizophrenia; LUSC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC trans rs72674100 1.000 rs10010641 chr4:97966171 C/T cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 2.88e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25275331 chr1:40723935 ZMPSTE24 -0.53 -6.77 -0.35 5.96e-11 Bipolar disorder and schizophrenia; LUSC cis rs9309473 0.948 rs11884776 chr2:73746923 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -6.43 -0.33 4.37e-10 Metabolite levels; LUSC cis rs2481665 0.902 rs1013293 chr1:62570321 G/A cg18591186 chr1:62594603 INADL -0.51 -7.97 -0.4 2.58e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -7.47 -0.38 7e-13 Body mass index (adult); LUSC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg19678392 chr7:94953810 PON1 -0.36 -5.91 -0.31 8.37e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs595982 0.527 rs17206707 chr19:49361441 A/C cg15549821 chr19:49342101 PLEKHA4 -0.58 -7.96 -0.4 2.7e-14 Red cell distribution width; LUSC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg13699009 chr12:122356056 WDR66 0.51 7.9 0.4 4.12e-14 Mean corpuscular volume; LUSC cis rs10080237 0.564 rs2490224 chr6:80809833 G/A cg08355045 chr6:80787529 NA 0.55 9.85 0.47 2.83e-20 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; LUSC cis rs9905704 0.918 rs2567901 chr17:56783255 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.75 0.39 1.15e-13 Testicular germ cell tumor; LUSC trans rs1941687 0.797 rs9965563 chr18:31398985 T/G cg27147174 chr7:100797783 AP1S1 -0.44 -6.34 -0.33 7.57e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1008375 1.000 rs9991307 chr4:17662408 A/G cg18681998 chr4:17616180 MED28 0.86 15.66 0.65 7.88e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1023500 0.507 rs6002600 chr22:42488906 G/A cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Schizophrenia; LUSC cis rs2204008 0.775 rs3900361 chr12:38238936 A/G cg26384229 chr12:38710491 ALG10B -0.88 -15.17 -0.64 6.65e-40 Bladder cancer; LUSC cis rs9341835 0.542 rs4710430 chr6:64165344 C/A cg03326410 chr6:64151739 NA -0.37 -6.01 -0.31 4.85e-9 Schizophrenia; LUSC cis rs7659604 0.540 rs11724322 chr4:122697850 A/T cg19748678 chr4:122722346 EXOSC9 -0.5 -7.53 -0.38 4.93e-13 Type 2 diabetes; LUSC cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg00012203 chr2:219082015 ARPC2 -0.56 -9.03 -0.44 1.38e-17 Ulcerative colitis; LUSC trans rs9944715 0.954 rs7245091 chr18:43743081 C/T cg01718231 chr17:29326311 RNF135 -0.44 -6.26 -0.32 1.15e-9 Red cell distribution width;Mean corpuscular volume; LUSC cis rs1215050 0.740 rs11097580 chr4:98767255 C/A cg05340658 chr4:99064831 C4orf37 0.44 6.97 0.36 1.68e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11122272 0.705 rs2808599 chr1:231533482 T/C cg06096015 chr1:231504339 EGLN1 0.58 10.37 0.49 5e-22 Hemoglobin concentration; LUSC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC cis rs7107174 0.901 rs866901 chr11:77926309 C/T cg02023728 chr11:77925099 USP35 0.52 7.06 0.36 9.72e-12 Testicular germ cell tumor; LUSC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg09359103 chr1:154839909 KCNN3 -0.7 -16.23 -0.66 4.49e-44 Prostate cancer; LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.32 0.59 8.9e-33 Platelet count; LUSC cis rs6121246 0.609 rs6087783 chr20:30421224 T/G cg21427119 chr20:30132790 HM13 -0.34 -5.7 -0.3 2.63e-8 Mean corpuscular hemoglobin; LUSC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.26 0.52 3.74e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs75920871 0.588 rs1815788 chr11:116834971 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.47 -0.33 3.47e-10 Subjective well-being; LUSC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg17330251 chr7:94953956 PON1 -0.41 -6.67 -0.34 1.08e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.47 0.53 6.9e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.37 8.03 0.4 1.71e-14 Tonsillectomy; LUSC trans rs2562456 0.833 rs11880624 chr19:21523830 C/T cg00806126 chr19:22604979 ZNF98 -0.43 -6.19 -0.32 1.78e-9 Pain; LUSC cis rs6489882 0.902 rs10774679 chr12:113374748 A/G cg20102336 chr12:113376681 OAS3 0.41 6.02 0.31 4.56e-9 Chronic lymphocytic leukemia; LUSC trans rs6600671 0.899 rs11249432 chr1:121283476 T/A cg00646200 chr1:148855367 NA 0.48 7.52 0.38 5.26e-13 Hip geometry; LUSC cis rs11122272 0.735 rs2749704 chr1:231526243 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.01 0.48 8.18e-21 Hemoglobin concentration; LUSC cis rs9653442 0.648 rs11123805 chr2:100643464 A/G cg22139774 chr2:100720529 AFF3 -0.47 -8.11 -0.41 9.86e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.95 0.4 2.83e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg05729581 chr11:3078854 CARS -0.56 -8.71 -0.43 1.48e-16 Longevity; LUSC cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg00677455 chr12:58241039 CTDSP2 -0.69 -10.66 -0.5 5.01e-23 Multiple sclerosis; LUSC cis rs763121 0.776 rs5757177 chr22:39007174 A/C cg06544989 chr22:39130855 UNC84B 0.33 5.68 0.3 2.91e-8 Menopause (age at onset); LUSC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg14416269 chr4:6271139 WFS1 -0.5 -10.33 -0.49 6.79e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg17971929 chr21:40555470 PSMG1 -0.63 -10.31 -0.49 8.12e-22 Cognitive function; LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg08470875 chr2:26401718 FAM59B -0.68 -9.35 -0.46 1.32e-18 Gut microbiome composition (summer); LUSC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.66 -0.39 1.97e-13 Height; LUSC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg05340658 chr4:99064831 C4orf37 0.61 10.29 0.49 9.22e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg08807101 chr21:30365312 RNF160 -0.54 -8.2 -0.41 5.09e-15 Dental caries; LUSC cis rs7264396 0.563 rs2425121 chr20:34326186 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.38 -0.42 1.49e-15 Total cholesterol levels; LUSC cis rs35146811 0.660 rs3779045 chr7:99779259 T/C cg22906224 chr7:99728672 NA 0.48 6.68 0.34 1.03e-10 Coronary artery disease; LUSC cis rs10782582 0.609 rs5745394 chr1:76311731 G/A cg10523679 chr1:76189770 ACADM -0.49 -7.06 -0.36 9.81e-12 Daytime sleep phenotypes; LUSC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg26597838 chr10:835615 NA 0.99 14.05 0.61 1.5e-35 Eosinophil percentage of granulocytes; LUSC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg03806693 chr22:41940476 POLR3H -0.93 -13.76 -0.6 1.95e-34 Vitiligo; LUSC cis rs16917546 1.000 rs10995249 chr10:64396916 C/T cg03961010 chr10:64397487 ZNF365 -0.41 -6.53 -0.34 2.45e-10 Basal cell carcinoma; LUSC cis rs13315871 0.929 rs11130628 chr3:58315835 T/C cg20936604 chr3:58311152 NA -0.72 -6.95 -0.36 1.87e-11 Cholesterol, total; LUSC cis rs2204008 0.505 rs11182550 chr12:38570061 A/T cg26384229 chr12:38710491 ALG10B 0.58 8.76 0.43 1.03e-16 Bladder cancer; LUSC cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs62458065 0.713 rs62463968 chr7:32501242 G/A cg20159608 chr7:32802032 NA -0.73 -9.28 -0.45 2.15e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg24450063 chr1:156163899 SLC25A44 1.19 30.8 0.86 1.26e-99 Testicular germ cell tumor; LUSC cis rs8062405 0.722 rs3785354 chr16:28550667 C/T cg16576597 chr16:28551801 NUPR1 0.33 6.51 0.34 2.83e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.61 7.82 0.39 6.91e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg19346786 chr7:2764209 NA -0.46 -7.72 -0.39 1.39e-13 Height; LUSC cis rs694739 0.930 rs574087 chr11:64102948 A/G cg02228329 chr11:64053129 BAD;GPR137 0.53 7.8 0.39 7.88e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs113835537 0.529 rs116867234 chr11:66209024 C/T cg24851651 chr11:66362959 CCS 0.55 8.0 0.4 2.09e-14 Airway imaging phenotypes; LUSC cis rs3126085 0.935 rs10749670 chr1:152220467 G/A cg03465714 chr1:152285911 FLG -0.4 -5.67 -0.3 3.07e-8 Atopic dermatitis; LUSC cis rs6723226 0.772 rs2366894 chr2:32713706 A/T cg02381751 chr2:32503542 YIPF4 0.58 8.86 0.44 4.85e-17 Intelligence (multi-trait analysis); LUSC cis rs709400 0.663 rs17617941 chr14:103953032 T/C cg12935359 chr14:103987150 CKB -0.56 -8.67 -0.43 1.92e-16 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09413313 chr11:28131866 METT5D1 -0.49 -7.42 -0.38 9.93e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs35110281 0.837 rs2838342 chr21:45077865 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.87 0.48 2.54e-20 Mean corpuscular volume; LUSC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg13114125 chr14:105738426 BRF1 -0.9 -15.31 -0.64 1.85e-40 Mean platelet volume;Platelet distribution width; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg20887711 chr4:1340912 KIAA1530 0.67 10.79 0.51 1.72e-23 Longevity; LUSC cis rs7824557 0.767 rs11775635 chr8:11164865 G/A cg21293242 chr8:11204541 TDH 0.32 5.97 0.31 5.93e-9 Retinal vascular caliber; LUSC cis rs2806561 0.765 rs652706 chr1:23514246 G/A cg19743168 chr1:23544995 NA 0.4 7.96 0.4 2.78e-14 Height; LUSC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg18350739 chr11:68623251 NA -0.38 -6.72 -0.35 7.94e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg14525755 chr12:132671672 NA 0.34 6.1 0.32 2.92e-9 Anti-saccade response; LUSC cis rs6845621 0.901 rs4697204 chr4:18921835 A/G cg12196642 chr4:18937545 NA 0.35 6.63 0.34 1.36e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs782590 0.557 rs7592219 chr2:55887176 T/C cg18811423 chr2:55921094 PNPT1 -0.63 -8.52 -0.42 5.56e-16 Metabolic syndrome; LUSC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.83 0.51 1.23e-23 Menopause (age at onset); LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.38 6.34 0.33 7.57e-10 Menopause (age at onset); LUSC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg16584290 chr5:462447 EXOC3 -0.37 -6.38 -0.33 5.84e-10 Cystic fibrosis severity; LUSC cis rs2806561 0.929 rs628096 chr1:23537676 C/G cg19743168 chr1:23544995 NA 0.47 10.23 0.49 1.53e-21 Height; LUSC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg05623727 chr3:50126028 RBM5 0.33 6.13 0.32 2.53e-9 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg12480416 chr8:128806471 PVT1 0.39 6.06 0.31 3.71e-9 Triglycerides; LUSC cis rs7568458 0.846 rs2028900 chr2:85767735 A/G cg02493740 chr2:85810744 VAMP5 0.36 6.47 0.33 3.48e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10789491 0.953 rs1866770 chr1:47182468 G/T cg15501359 chr1:47185051 KIAA0494 0.81 11.35 0.53 1.79e-25 Response to hepatitis C treatment; LUSC cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg17279839 chr7:150038598 RARRES2 -0.41 -6.34 -0.33 7.28e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs4664304 0.966 rs1397707 chr2:160760972 C/T cg03641300 chr2:160917029 PLA2R1 -0.4 -6.49 -0.33 3.1e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.69 0.34 9.27e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.42 6.27 0.32 1.09e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs9549367 0.789 rs9549695 chr13:113874814 A/G cg00898013 chr13:113819073 PROZ 0.52 7.51 0.38 5.62e-13 Platelet distribution width; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg02666966 chr16:28857347 TUFM 0.41 6.48 0.33 3.21e-10 Asthma; LUSC cis rs7208859 0.623 rs6505207 chr17:29076571 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg00409905 chr10:38381863 ZNF37A -0.35 -5.98 -0.31 5.62e-9 Extrinsic epigenetic age acceleration; LUSC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.63 0.34 1.34e-10 Lung cancer; LUSC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg14784868 chr12:69753453 YEATS4 0.63 8.79 0.43 8.24e-17 Cerebrospinal fluid biomarker levels; LUSC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.69e-14 Systolic blood pressure; LUSC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg01579765 chr21:45077557 HSF2BP -0.54 -11.54 -0.53 3.66e-26 Mean corpuscular volume; LUSC cis rs12681287 0.640 rs13251006 chr8:87469105 C/T cg27223183 chr8:87520930 FAM82B -0.54 -7.45 -0.38 7.92e-13 Caudate activity during reward; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg13047869 chr3:10149882 C3orf24 0.61 8.57 0.42 4.03e-16 Alzheimer's disease; LUSC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg09021430 chr5:549028 NA 0.55 7.55 0.38 4.13e-13 Obesity-related traits; LUSC cis rs1949733 1.000 rs1916326 chr4:8500023 G/A cg11789530 chr4:8429930 ACOX3 -0.62 -9.43 -0.46 7.08e-19 Response to antineoplastic agents; LUSC cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg12935359 chr14:103987150 CKB 0.6 9.56 0.46 2.72e-19 Intelligence (multi-trait analysis); LUSC cis rs1150668 0.796 rs728122 chr6:28399124 G/A cg21251018 chr6:28226885 NKAPL 0.3 5.66 0.3 3.21e-8 Pubertal anthropometrics; LUSC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg24450063 chr1:156163899 SLC25A44 1.21 30.68 0.86 3.34e-99 Testicular germ cell tumor; LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC cis rs6545883 0.965 rs3771261 chr2:61762161 A/G cg15711740 chr2:61764176 XPO1 -0.49 -7.77 -0.39 9.91e-14 Tuberculosis; LUSC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC cis rs7523050 0.730 rs67312582 chr1:109423976 A/G cg08274380 chr1:109419600 GPSM2 1.13 11.51 0.53 4.76e-26 Fat distribution (HIV); LUSC cis rs16867335 1.000 rs72884242 chr2:181465486 A/T cg23363182 chr2:181467187 NA -0.46 -5.87 -0.31 1.05e-8 Survival in rectal cancer; LUSC cis rs12541635 0.513 rs7841482 chr8:106992286 T/C cg10147462 chr8:107024639 NA 0.4 5.86 0.31 1.08e-8 Age of smoking initiation; LUSC trans rs877282 0.853 rs4579862 chr10:753298 A/C cg22713356 chr15:30763199 NA 0.96 12.36 0.56 3.6e-29 Uric acid levels; LUSC trans rs10098647 0.603 rs11774878 chr8:61111576 G/A cg09970348 chr3:183978600 ECE2;CAMK2N2 0.46 6.15 0.32 2.26e-9 Obesity-related traits; LUSC cis rs2708377 0.929 rs73053785 chr12:11162411 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.82 8.17 0.41 6.33e-15 Bitter taste perception; LUSC cis rs7107174 1.000 rs114142124 chr11:78047537 T/C cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7937682 0.924 rs489783 chr11:111520522 A/G cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03132089 chr20:55926498 RAE1 0.78 6.35 0.33 6.9e-10 Cognitive performance; LUSC cis rs1808579 1.000 rs1808579 chr18:21104888 C/T cg14672496 chr18:21087552 C18orf8 0.35 6.02 0.31 4.65e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs1595825 0.891 rs73054867 chr2:198700417 C/G cg00982548 chr2:198649783 BOLL -0.58 -7.2 -0.37 3.9e-12 Ulcerative colitis; LUSC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs2562456 0.792 rs2562398 chr19:21722949 A/G cg00806126 chr19:22604979 ZNF98 0.37 5.75 0.3 1.97e-8 Pain; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.01 -0.31 4.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12760731 0.720 rs10913552 chr1:178411543 G/A cg00404053 chr1:178313656 RASAL2 0.55 6.21 0.32 1.55e-9 Obesity-related traits; LUSC cis rs4845570 0.920 rs10788809 chr1:151760792 A/G cg07092448 chr1:151763213 TDRKH 1.27 14.77 0.63 2.37e-38 Coronary artery disease; LUSC cis rs4268898 0.662 rs58971404 chr2:24403753 G/A cg06627628 chr2:24431161 ITSN2 -0.86 -12.07 -0.55 4.48e-28 Asthma; LUSC cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg05283184 chr6:79620031 NA -0.57 -12.13 -0.55 2.55e-28 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg25258033 chr6:167368657 RNASET2 0.46 7.67 0.39 1.91e-13 Crohn's disease; LUSC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg01097406 chr16:89675127 NA -0.34 -6.82 -0.35 4.39e-11 Vitiligo; LUSC cis rs5758659 0.714 rs5751216 chr22:42508937 G/T cg15557168 chr22:42548783 NA 0.35 5.82 0.3 1.41e-8 Cognitive function; LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg08280861 chr8:58055591 NA 0.54 5.66 0.3 3.23e-8 Developmental language disorder (linguistic errors); LUSC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21582582 chr3:182698605 DCUN1D1 0.46 8.24 0.41 3.84e-15 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -12.11 -0.55 3.12e-28 Mean corpuscular volume; LUSC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg08859206 chr1:53392774 SCP2 0.51 8.82 0.43 6.65e-17 Monocyte count; LUSC cis rs72949976 0.646 rs13029384 chr2:214029164 G/A cg08319019 chr2:214017104 IKZF2 0.67 11.14 0.52 1.02e-24 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs4903604 0.581 rs4903606 chr14:78036935 A/G cg18872420 chr14:78023429 SPTLC2 0.38 5.87 0.31 1.04e-8 Gut microbiome composition (winter); LUSC trans rs7681440 0.904 rs2301134 chr4:90758945 A/G cg02113368 chr10:135107346 TUBGCP2 -0.34 -5.95 -0.31 6.71e-9 Dementia with Lewy bodies; LUSC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg23093090 chr10:104574429 C10orf26 -0.47 -8.34 -0.42 2.02e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9467773 1.000 rs1535277 chr6:26567802 G/T cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC cis rs2274273 0.588 rs2297816 chr14:55833038 A/G cg04306507 chr14:55594613 LGALS3 0.47 9.11 0.45 7.86e-18 Protein biomarker; LUSC cis rs7949030 0.964 rs2957122 chr11:62392100 G/C cg11742103 chr11:62369870 EML3;MTA2 -0.48 -8.14 -0.41 7.78e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7618501 0.602 rs2245365 chr3:50097319 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.24 -0.45 2.89e-18 Intelligence (multi-trait analysis); LUSC cis rs7100689 0.646 rs1340376 chr10:82128963 A/G cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC trans rs10117734 0.632 rs10974525 chr9:4417406 A/G cg11716681 chr21:18884682 CXADR -0.41 -6.01 -0.31 4.82e-9 Parental extreme longevity (95 years and older); LUSC cis rs11608355 1.000 rs11608355 chr12:109879292 T/C cg05360138 chr12:110035743 NA 0.45 6.26 0.32 1.15e-9 Neuroticism; LUSC cis rs9948 0.655 rs62156213 chr2:97399100 T/C cg01990225 chr2:97406019 LMAN2L -1.03 -7.11 -0.36 7.29e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs11583043 1.000 rs17123612 chr1:101476814 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.74 0.3 2.08e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs34421088 0.560 rs2248325 chr8:11396874 A/G cg06636001 chr8:8085503 FLJ10661 -0.59 -9.16 -0.45 5.26e-18 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09302904 chr17:62340561 TEX2 0.41 6.03 0.31 4.39e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs68170813 0.563 rs6979198 chr7:107197694 T/G cg02696742 chr7:106810147 HBP1 -0.68 -9.94 -0.48 1.48e-20 Coronary artery disease; LUSC cis rs1577917 0.958 rs12199832 chr6:86652748 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.46 -0.42 8.33e-16 Response to antipsychotic treatment; LUSC trans rs7939886 0.920 rs79521305 chr11:55811332 G/A cg15704280 chr7:45808275 SEPT13 0.83 6.92 0.35 2.38e-11 Myopia (pathological); LUSC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg20908204 chr19:46285434 DMPK -0.45 -8.37 -0.42 1.61e-15 Coronary artery disease; LUSC trans rs7937682 0.632 rs11823089 chr11:111673539 A/G cg18187862 chr3:45730750 SACM1L -0.52 -6.3 -0.33 9.38e-10 Primary sclerosing cholangitis; LUSC cis rs11676348 0.808 rs4674261 chr2:219005009 G/C cg06547715 chr2:218990976 CXCR2 0.31 5.86 0.31 1.14e-8 Ulcerative colitis; LUSC cis rs5769707 0.568 rs2011097 chr22:50018069 A/G cg10356904 chr22:49881777 NA -0.28 -5.72 -0.3 2.34e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg09184832 chr6:79620586 NA -0.44 -6.84 -0.35 3.73e-11 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.659 rs9303399 chr17:56672309 C/T cg25039879 chr17:56429692 SUPT4H1 0.65 8.58 0.42 3.66e-16 Cognitive test performance; LUSC cis rs1775715 0.870 rs1755080 chr10:32255195 G/A cg04359828 chr10:32216031 ARHGAP12 0.38 6.24 0.32 1.33e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs300703 0.515 rs364431 chr2:191399 C/A cg21211680 chr2:198530 NA 0.53 6.44 0.33 4.26e-10 Blood protein levels; LUSC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -11.48 -0.53 6.36e-26 Systemic lupus erythematosus; LUSC cis rs7599312 0.534 rs2371615 chr2:213405660 G/T cg16329650 chr2:213403929 ERBB4 0.86 18.62 0.71 1.47e-53 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs8002861 0.754 rs4053664 chr13:44429172 A/C cg12856521 chr11:46389249 DGKZ 0.41 6.52 0.34 2.54e-10 Leprosy; LUSC cis rs17253792 0.822 rs28513551 chr14:56094993 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.12e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs2235642 0.717 rs9937922 chr16:1658154 C/G cg26528668 chr16:1614120 IFT140 0.42 7.12 0.36 6.79e-12 Coronary artery disease; LUSC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg22903471 chr2:27725779 GCKR -0.41 -6.92 -0.35 2.3e-11 Total body bone mineral density; LUSC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg14552801 chr7:65878734 NA 0.38 6.0 0.31 5.06e-9 Aortic root size; LUSC cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 6.81 0.35 4.56e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -8.24 -0.41 4.07e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs73206853 0.698 rs1018133 chr12:111121302 G/C cg12870014 chr12:110450643 ANKRD13A 0.67 7.36 0.37 1.45e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1801251 0.752 rs2592126 chr2:233751377 A/G cg08000102 chr2:233561755 GIGYF2 -0.51 -7.86 -0.39 5.45e-14 Coronary artery disease; LUSC cis rs28830936 1.000 rs11070343 chr15:41940146 T/A cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.5 -0.34 2.95e-10 Diastolic blood pressure; LUSC cis rs4474465 0.850 rs7122676 chr11:78268525 A/G cg27205649 chr11:78285834 NARS2 0.53 6.3 0.33 9.42e-10 Alzheimer's disease (survival time); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13110350 chr12:46383601 SFRS2IP -0.39 -5.95 -0.31 6.75e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7799006 0.964 rs3757440 chr7:2272936 A/G cg08027265 chr7:2291960 NA -0.39 -6.86 -0.35 3.35e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.47 7.48 0.38 6.58e-13 Menarche (age at onset); LUSC cis rs7568458 0.516 rs62166769 chr2:85812784 T/A cg17127132 chr2:85788382 GGCX 0.41 6.0 0.31 5.13e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9325144 0.624 rs10783329 chr12:39113951 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.61 -0.38 2.77e-13 Morning vs. evening chronotype; LUSC cis rs1018836 0.773 rs7837109 chr8:91639178 C/T cg16814680 chr8:91681699 NA -0.78 -13.01 -0.58 1.39e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9354308 0.966 rs1909533 chr6:66565658 G/A cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg23625390 chr15:77176239 SCAPER 0.53 8.37 0.42 1.55e-15 Blood metabolite levels; LUSC cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg13010199 chr12:38710504 ALG10B -0.62 -10.36 -0.49 5.5e-22 Heart rate; LUSC cis rs11711311 0.955 rs3796254 chr3:113380332 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -6.15 -0.32 2.27e-9 IgG glycosylation; LUSC cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg24450063 chr1:156163899 SLC25A44 1.11 25.05 0.81 1.11e-78 Testicular germ cell tumor; LUSC cis rs8060686 0.545 rs12444313 chr16:68254404 A/C cg27539214 chr16:67997921 SLC12A4 -0.57 -7.02 -0.36 1.24e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs6733011 0.578 rs6714243 chr2:99510039 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -5.91 -0.31 8.33e-9 Bipolar disorder; LUSC cis rs12472274 0.536 rs12619455 chr2:239080149 A/C cg17459225 chr2:239074497 NA 0.57 7.57 0.38 3.71e-13 Phospholipid levels (plasma); LUSC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg10130564 chr11:117069849 TAGLN 0.38 6.65 0.34 1.17e-10 Blood protein levels; LUSC cis rs193541 0.626 rs6869140 chr5:122088686 A/G cg19077854 chr5:122220652 SNX24 -0.29 -6.4 -0.33 5.3e-10 Glucose homeostasis traits; LUSC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg23221052 chr5:179740743 GFPT2 -0.56 -8.73 -0.43 1.2e-16 Height; LUSC cis rs868036 0.718 rs28675295 chr15:68116400 C/A cg24579218 chr15:68104479 NA -0.4 -7.05 -0.36 1.02e-11 Restless legs syndrome; LUSC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg05393297 chr12:53359155 NA -0.74 -11.43 -0.53 9e-26 Cancer (pleiotropy); LUSC cis rs1595825 0.735 rs6434955 chr2:198946551 G/A cg00982548 chr2:198649783 BOLL -0.54 -6.67 -0.34 1.08e-10 Ulcerative colitis; LUSC trans rs9910292 0.591 rs8074010 chr17:31358083 A/G cg03789507 chr8:136667083 NA 0.48 6.13 0.32 2.44e-9 Mosquito bite size; LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC trans rs1973993 0.651 rs60776572 chr1:96960121 C/T cg10631902 chr5:14652156 NA -0.46 -6.8 -0.35 4.72e-11 Weight; LUSC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg10523679 chr1:76189770 ACADM 0.89 14.57 0.62 1.41e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs2580764 0.540 rs10174838 chr2:55241216 A/T cg09592903 chr2:55203963 RTN4 -0.49 -9.99 -0.48 1.02e-20 Mean platelet volume; LUSC cis rs7202877 0.610 rs1010631 chr16:75328590 C/G cg04384234 chr16:75411784 CFDP1 -0.62 -8.66 -0.43 2.05e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.62e-8 Intelligence (multi-trait analysis); LUSC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 7.03 0.36 1.18e-11 Multiple sclerosis; LUSC cis rs3808502 0.534 rs1529858 chr8:11145662 G/T cg21775007 chr8:11205619 TDH 0.5 7.03 0.36 1.15e-11 Neuroticism; LUSC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg25811766 chr13:21894605 NA 0.62 9.56 0.46 2.6e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs6541297 1.000 rs6541296 chr1:230281953 A/G cg20703242 chr1:230279135 GALNT2 0.57 8.71 0.43 1.39e-16 Coronary artery disease; LUSC trans rs2797160 0.967 rs984041 chr6:126021328 A/T cg05039488 chr6:79577232 IRAK1BP1 0.46 6.95 0.36 1.87e-11 Endometrial cancer; LUSC cis rs113835537 0.935 rs79106199 chr11:66420518 T/C cg24851651 chr11:66362959 CCS 0.53 6.54 0.34 2.38e-10 Airway imaging phenotypes; LUSC cis rs208520 0.690 rs9345764 chr6:66820597 C/T cg07460842 chr6:66804631 NA -1.15 -18.02 -0.7 3.41e-51 Exhaled nitric oxide output; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04869497 chr17:20059225 CYTSB -0.44 -6.28 -0.32 1.03e-9 Electrocardiographic conduction measures; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 14.15 0.61 6.37e-36 Alzheimer's disease; LUSC cis rs9303401 0.659 rs1864754 chr17:56688789 G/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.86 -13.29 -0.59 1.22e-32 Cognitive test performance; LUSC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs9300255 0.596 rs11057207 chr12:123730891 T/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.36 -0.33 6.49e-10 Neutrophil percentage of white cells; LUSC cis rs7267979 1.000 rs34645895 chr20:25368373 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs921968 0.608 rs678814 chr2:219359287 T/C cg02176678 chr2:219576539 TTLL4 0.64 11.53 0.53 4.11e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs9527 1.000 rs9527 chr10:104623578 C/T cg04362960 chr10:104952993 NT5C2 0.66 9.15 0.45 5.6e-18 Arsenic metabolism; LUSC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg22875332 chr1:76189707 ACADM -0.85 -14.19 -0.61 4.47e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11264799 0.603 rs12733062 chr1:157585932 C/A cg18268488 chr1:157545234 FCRL4 0.35 6.51 0.34 2.82e-10 IgA nephropathy; LUSC cis rs3768617 0.510 rs7414273 chr1:183075017 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.81 0.51 1.45e-23 Fuchs's corneal dystrophy; LUSC cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg13256891 chr4:100009986 ADH5 0.51 6.96 0.36 1.79e-11 Smoking initiation; LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg02353165 chr6:42928485 GNMT 0.76 13.76 0.6 1.94e-34 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1790761 0.967 rs1808279 chr11:67211569 T/C cg24690094 chr11:67383802 NA -0.32 -5.86 -0.31 1.12e-8 Mean corpuscular volume; LUSC cis rs9616064 0.889 rs7284276 chr22:46996137 G/C cg25730555 chr22:47059586 GRAMD4 0.44 6.57 0.34 1.88e-10 Urate levels in obese individuals; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg11494091 chr17:61959527 GH2 0.63 13.45 0.59 2.99e-33 Prudent dietary pattern; LUSC cis rs3772130 0.540 rs7627354 chr3:121562434 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.83 13.54 0.6 1.29e-33 Cognitive performance; LUSC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs6066835 1.000 rs6063314 chr20:47353106 T/C cg18078177 chr20:47281410 PREX1 0.71 6.21 0.32 1.61e-9 Multiple myeloma; LUSC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg22535103 chr8:58192502 C8orf71 -0.62 -6.98 -0.36 1.62e-11 Developmental language disorder (linguistic errors); LUSC cis rs8062405 1.000 rs72793812 chr16:28840381 A/G cg09754948 chr16:28834200 ATXN2L 0.43 6.24 0.32 1.34e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9467773 0.967 rs6456732 chr6:26514445 T/C cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.15e-18 Intelligence (multi-trait analysis); LUSC cis rs4343996 0.714 rs10268837 chr7:3467366 T/C cg21248987 chr7:3385318 SDK1 0.34 5.7 0.3 2.64e-8 Motion sickness; LUSC cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg06191203 chr2:152266755 RIF1 -0.53 -7.1 -0.36 7.36e-12 Lung cancer; LUSC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg16520312 chr17:43971471 MAPT;LOC100128977 -0.49 -7.96 -0.4 2.64e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg14830002 chr1:247616686 OR2B11 0.51 7.05 0.36 1.06e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg02772935 chr3:125709198 NA -0.49 -5.87 -0.31 1.06e-8 Blood pressure (smoking interaction); LUSC cis rs17828380 1.000 rs35446744 chr15:63509930 T/C cg05507819 chr15:63340323 TPM1 -0.7 -5.9 -0.31 8.94e-9 Social communication problems; LUSC cis rs1322512 0.874 rs1407483 chr6:152963780 C/T cg27316956 chr6:152958899 SYNE1 -0.37 -6.32 -0.33 8.6e-10 Tonometry; LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg07157834 chr1:205819609 PM20D1 -0.53 -8.23 -0.41 4.31e-15 Menarche (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24953233 chr5:892707 TRIP13;BRD9 -0.42 -6.41 -0.33 4.84e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs72674100 1.000 rs17026376 chr4:97993847 G/A cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10193935 0.892 rs7574609 chr2:42388468 C/A cg27598129 chr2:42591480 NA -0.59 -8.1 -0.41 1.01e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11958404 0.932 rs72818109 chr5:157438340 A/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg23625390 chr15:77176239 SCAPER -0.47 -6.9 -0.35 2.55e-11 Blood metabolite levels; LUSC cis rs3106136 0.934 rs2902979 chr4:95177874 C/G cg11021082 chr4:95130006 SMARCAD1 -0.36 -6.31 -0.33 9.01e-10 Capecitabine sensitivity; LUSC cis rs295140 0.605 rs34693942 chr2:201184348 T/C cg04283868 chr2:201171347 SPATS2L 0.39 5.72 0.3 2.34e-8 QT interval; LUSC cis rs477692 0.967 rs496692 chr10:131429100 C/T cg26102564 chr10:131424627 MGMT 0.41 6.4 0.33 5.33e-10 Response to temozolomide; LUSC cis rs13401104 0.796 rs72620807 chr2:237114205 T/G cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.35e-8 Educational attainment; LUSC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg00012203 chr2:219082015 ARPC2 -0.69 -11.35 -0.53 1.78e-25 Colorectal cancer; LUSC cis rs76878669 0.538 rs4930360 chr11:66143247 T/A cg24851651 chr11:66362959 CCS -0.38 -6.07 -0.32 3.42e-9 Educational attainment (years of education); LUSC cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg06064525 chr11:970664 AP2A2 -0.35 -7.16 -0.36 5.14e-12 Alzheimer's disease (late onset); LUSC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg11211951 chr8:145729740 GPT -0.58 -11.23 -0.52 4.97e-25 Age at first birth; LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg04944784 chr2:26401820 FAM59B 0.72 8.76 0.43 9.83e-17 Gut microbiome composition (summer); LUSC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg16447950 chr5:562315 NA -0.59 -7.06 -0.36 9.96e-12 Lung disease severity in cystic fibrosis; LUSC cis rs4243830 0.737 rs56036909 chr1:6608503 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.87 10.06 0.48 5.67e-21 Body mass index; LUSC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg21963583 chr11:68658836 MRPL21 0.55 8.23 0.41 4.19e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg22532475 chr10:104410764 TRIM8 -0.35 -7.76 -0.39 1.01e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6076065 0.894 rs2243448 chr20:23378345 G/A cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg19678392 chr7:94953810 PON1 -0.36 -5.68 -0.3 3.01e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7296418 0.961 rs1790121 chr12:123604492 G/A cg13010344 chr12:123464640 ARL6IP4 -0.52 -8.11 -0.41 1e-14 Platelet count; LUSC trans rs4332037 0.707 rs73046323 chr7:1882795 G/A cg25206134 chr2:45395956 NA 0.52 6.06 0.31 3.71e-9 Bipolar disorder; LUSC cis rs9788721 0.775 rs12914385 chr15:78898723 C/T cg18825076 chr15:78729989 IREB2 -0.51 -7.96 -0.4 2.75e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6969780 0.778 rs79619106 chr7:27146328 A/C cg26364809 chr7:27145159 NA -0.59 -5.98 -0.31 5.69e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs73198271 0.694 rs114184516 chr8:8647082 A/G cg01851573 chr8:8652454 MFHAS1 0.52 8.12 0.41 9.04e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.53 9.36 0.46 1.17e-18 Menopause (age at onset); LUSC cis rs7523273 0.606 rs2796263 chr1:207915978 T/C cg22525895 chr1:207977042 MIR29B2 0.4 6.62 0.34 1.42e-10 Schizophrenia; LUSC cis rs72781680 0.848 rs56218741 chr2:23977377 A/C cg08917208 chr2:24149416 ATAD2B 0.87 9.69 0.47 9.99e-20 Lymphocyte counts; LUSC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs2742417 1.000 rs2742417 chr3:45731451 C/T cg09608765 chr3:45636137 LIMD1 -0.39 -7.83 -0.39 6.72e-14 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg25643088 chr3:52874325 TMEM110 0.39 5.82 0.3 1.4e-8 Schizophrenia; LUSC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg18876405 chr7:65276391 NA 0.67 11.9 0.55 1.85e-27 Aortic root size; LUSC cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg15556689 chr8:8085844 FLJ10661 0.62 9.24 0.45 3.04e-18 Neuroticism; LUSC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg25743719 chr2:10443138 HPCAL1 -0.47 -6.19 -0.32 1.75e-9 Height; LUSC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11644478 chr21:40555479 PSMG1 -0.8 -14.45 -0.62 4.18e-37 Cognitive function; LUSC cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg06671706 chr8:8559999 CLDN23 0.51 6.86 0.35 3.32e-11 Obesity-related traits; LUSC cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg03146154 chr1:46216737 IPP 0.51 7.6 0.38 3.05e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs911119 1.000 rs1064039 chr20:23618427 C/T cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC cis rs9486719 0.741 rs2049927 chr6:96848958 C/G cg06623918 chr6:96969491 KIAA0776 -0.67 -7.83 -0.39 6.38e-14 Migraine;Coronary artery disease; LUSC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg03929089 chr4:120376271 NA -0.96 -15.49 -0.65 3.54e-41 Coronary artery disease; LUSC cis rs77861329 1.000 rs352148 chr3:52208898 A/G cg08692210 chr3:52188851 WDR51A 0.86 7.38 0.37 1.27e-12 Macrophage inflammatory protein 1b levels; LUSC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg03804128 chr16:635623 NA 0.32 6.51 0.34 2.8e-10 Height; LUSC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg07150166 chr2:30669952 LCLAT1 0.63 6.86 0.35 3.41e-11 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg16060761 chr17:80687452 NA -0.4 -6.2 -0.32 1.65e-9 Breast cancer; LUSC cis rs3768617 0.510 rs2093985 chr1:183094322 C/T ch.1.3577855R chr1:183094577 LAMC1 0.73 11.23 0.52 4.84e-25 Fuchs's corneal dystrophy; LUSC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg15605315 chr1:45957053 TESK2 0.51 8.5 0.42 6.26e-16 High light scatter reticulocyte count; LUSC cis rs3733606 0.503 rs11731274 chr4:6891455 T/G cg05012661 chr4:6891264 NA 0.56 7.93 0.4 3.28e-14 Platelet count; LUSC cis rs6867032 0.570 rs13166888 chr5:1982966 G/T cg26168224 chr5:2018326 NA -0.59 -8.27 -0.41 3.31e-15 Gut microbiome composition (winter); LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.69 -10.09 -0.48 4.37e-21 Systemic lupus erythematosus; LUSC cis rs7940866 0.804 rs10894289 chr11:130808685 C/T cg12179176 chr11:130786555 SNX19 0.64 9.71 0.47 8.83e-20 Schizophrenia; LUSC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.18 0.58 3.15e-32 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2820315 1.000 rs2644107 chr1:201818629 T/C cg10061532 chr1:201886748 LMOD1 0.25 5.67 0.3 3.07e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2055729 1.000 rs2055729 chr8:9792662 C/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.06 -0.31 3.74e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs9311676 0.656 rs62258102 chr3:58378784 T/C cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC cis rs7177699 0.557 rs12898712 chr15:79112622 G/T cg00540400 chr15:79124168 NA 0.46 7.98 0.4 2.33e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs738322 0.810 rs4820323 chr22:38599767 C/G cg17652424 chr22:38574118 PLA2G6 0.28 5.68 0.3 2.9e-8 Cutaneous nevi; LUSC cis rs2797160 1.000 rs77678056 chr6:126019738 A/G cg05901451 chr6:126070800 HEY2 0.57 8.55 0.42 4.55e-16 Endometrial cancer; LUSC cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9463078 0.605 rs9472409 chr6:44926431 A/G cg25276700 chr6:44698697 NA 0.28 5.92 0.31 8.11e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1808579 0.904 rs1788761 chr18:21133084 A/G cg14672496 chr18:21087552 C18orf8 0.38 6.68 0.34 9.81e-11 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs11166629 1.000 rs6577713 chr8:135645592 C/A cg27224718 chr8:135614730 ZFAT 0.65 10.8 0.51 1.64e-23 Smoking quantity; LUSC cis rs75920871 0.528 rs7935834 chr11:116944437 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.52 -0.34 2.56e-10 Subjective well-being; LUSC cis rs76878669 0.561 rs10750784 chr11:66110666 A/G cg24851651 chr11:66362959 CCS 0.36 5.7 0.3 2.67e-8 Educational attainment (years of education); LUSC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg12923728 chr3:195709715 SDHAP1 -0.79 -12.47 -0.56 1.41e-29 Pancreatic cancer; LUSC cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg04998671 chr14:104000505 TRMT61A 0.4 5.81 0.3 1.44e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg25767906 chr1:53392781 SCP2 0.39 6.64 0.34 1.29e-10 Monocyte count; LUSC cis rs8060686 0.545 rs3826164 chr16:68280317 A/G cg05110241 chr16:68378359 PRMT7 0.69 7.39 0.38 1.16e-12 HDL cholesterol;Metabolic syndrome; LUSC trans rs2490361 1.000 rs2485595 chr1:237326756 G/A cg21969473 chr17:17140219 FLCN 0.37 6.07 0.32 3.41e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1003719 0.743 rs2835615 chr21:38497303 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.69 -10.77 -0.51 2.07e-23 Eye color traits; LUSC cis rs1712517 0.771 rs10883857 chr10:105127587 A/C cg05636881 chr10:105038444 INA -0.38 -6.3 -0.33 9.33e-10 Migraine; LUSC cis rs11997175 0.646 rs67480501 chr8:33736315 C/T ch.8.33884649F chr8:33765107 NA 0.53 8.04 0.4 1.6e-14 Body mass index; LUSC cis rs75920871 0.502 rs7124996 chr11:116928006 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.49 -6.32 -0.33 8.51e-10 Subjective well-being; LUSC cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg13010199 chr12:38710504 ALG10B 0.62 9.23 0.45 3.2e-18 Bladder cancer; LUSC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg14416269 chr4:6271139 WFS1 0.53 11.29 0.53 2.9e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2235642 0.750 rs763152 chr16:1658056 T/C cg26528668 chr16:1614120 IFT140 0.42 7.12 0.36 6.79e-12 Coronary artery disease; LUSC cis rs8141529 1.000 rs8141529 chr22:29269692 A/G cg15103426 chr22:29168792 CCDC117 0.51 6.41 0.33 4.97e-10 Lymphocyte counts; LUSC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg13531842 chr10:38383804 ZNF37A -0.44 -6.84 -0.35 3.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7727544 0.582 rs2278398 chr5:131530441 C/T cg14196790 chr5:131705035 SLC22A5 -0.42 -7.13 -0.36 6.29e-12 Blood metabolite levels; LUSC cis rs1577917 0.958 rs12660846 chr6:86573809 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -9.1 -0.45 8.5e-18 Response to antipsychotic treatment; LUSC cis rs4900538 0.963 rs4906205 chr14:102932447 A/G cg18135206 chr14:102964638 TECPR2 0.99 20.51 0.75 4.32e-61 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.21 0.32 1.54e-9 Personality dimensions; LUSC cis rs34779708 0.931 rs4934731 chr10:35431636 T/C cg04310649 chr10:35416472 CREM -0.41 -6.47 -0.33 3.48e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12145833 0.596 rs12134228 chr1:243447618 C/T cg02356786 chr1:243265016 LOC731275 0.66 6.32 0.33 8.59e-10 Obesity (early onset extreme); LUSC cis rs1372520 0.873 rs2737026 chr4:90779823 A/G cg15133208 chr4:90757351 SNCA -0.54 -8.24 -0.41 3.96e-15 Neuroticism; LUSC cis rs10979 1.000 rs12191231 chr6:143891114 A/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg20283391 chr11:68216788 NA 0.54 8.12 0.41 9.02e-15 Total body bone mineral density; LUSC cis rs4969178 0.965 rs4969179 chr17:76391454 A/C cg05887092 chr17:76393375 PGS1 0.53 9.36 0.46 1.22e-18 HDL cholesterol levels; LUSC cis rs6893807 0.778 rs35991856 chr5:87968347 C/A cg02225085 chr5:87975992 LOC645323 -0.47 -5.94 -0.31 7.31e-9 Body mass index; LUSC cis rs5769765 0.526 rs5770722 chr22:50253220 G/C cg02269571 chr22:50332266 NA 0.58 7.48 0.38 6.75e-13 Schizophrenia; LUSC cis rs8141797 0.901 rs8138467 chr22:24458096 A/G cg00411358 chr22:24577142 SUSD2 0.62 6.08 0.32 3.31e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.55 -8.01 -0.4 1.91e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.38 -5.64 -0.3 3.58e-8 Schizophrenia; LUSC trans rs4332037 0.624 rs58169303 chr7:1883274 T/C cg11693508 chr17:37793320 STARD3 0.52 6.43 0.33 4.41e-10 Bipolar disorder; LUSC cis rs533581 0.866 rs475796 chr16:88970776 C/G cg16701003 chr16:89028210 CBFA2T3 0.32 5.67 0.3 3.04e-8 Social autistic-like traits; LUSC cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg21545522 chr1:205238299 TMCC2 0.51 9.63 0.47 1.51e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs3126085 0.935 rs12409762 chr1:152175398 G/A cg26876637 chr1:152193138 HRNR -0.43 -6.2 -0.32 1.67e-9 Atopic dermatitis; LUSC cis rs66569888 0.789 rs66826026 chr2:106732879 C/T cg16099169 chr2:106886729 NA -0.55 -7.08 -0.36 8.48e-12 Facial morphology (factor 23); LUSC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg00784671 chr22:46762841 CELSR1 -0.48 -6.49 -0.33 3.15e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs35995292 0.534 rs11980627 chr7:38907533 T/C cg19327137 chr7:38886074 VPS41 0.54 10.32 0.49 7.22e-22 Subjective well-being (multi-trait analysis); LUSC cis rs1949733 1.000 rs1880023 chr4:8480831 C/T cg11789530 chr4:8429930 ACOX3 -0.63 -9.85 -0.47 2.99e-20 Response to antineoplastic agents; LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC cis rs7119 0.717 rs12904584 chr15:77815991 C/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg22875332 chr1:76189707 ACADM -0.84 -17.3 -0.69 2.58e-48 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs66887589 0.776 rs10518337 chr4:120574874 A/C cg09307838 chr4:120376055 NA -0.48 -6.9 -0.35 2.67e-11 Diastolic blood pressure; LUSC cis rs2486288 0.656 rs8039540 chr15:45551842 C/G cg09092052 chr15:45571596 NA 0.45 6.26 0.32 1.18e-9 Glomerular filtration rate; LUSC cis rs116988415 0.584 rs17180252 chr14:65239316 G/A cg00114569 chr14:65239327 SPTB 0.7 6.78 0.35 5.46e-11 Daytime sleep phenotypes; LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs2197308 0.643 rs1842597 chr12:37862142 C/G cg26384229 chr12:38710491 ALG10B -0.83 -14.16 -0.61 5.82e-36 Morning vs. evening chronotype; LUSC cis rs4523957 0.890 rs9895551 chr17:2115922 C/G cg16513277 chr17:2031491 SMG6 0.58 9.53 0.46 3.27e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs62238980 0.614 rs78443579 chr22:32449283 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs728616 0.558 rs34268041 chr10:82148639 A/G cg05935833 chr10:81318306 SFTPA2 -0.43 -5.73 -0.3 2.28e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg07157834 chr1:205819609 PM20D1 0.98 21.45 0.76 8.76e-65 Menarche (age at onset); LUSC cis rs7927771 0.524 rs2242081 chr11:47500267 T/C cg20307385 chr11:47447363 PSMC3 0.44 6.45 0.33 4.01e-10 Subjective well-being; LUSC cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg09307838 chr4:120376055 NA -0.73 -11.36 -0.53 1.72e-25 Corneal astigmatism; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg04625536 chr6:42533006 UBR2 0.36 6.23 0.32 1.37e-9 Tuberculosis; LUSC cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg23625390 chr15:77176239 SCAPER 0.54 8.49 0.42 6.9e-16 Blood metabolite levels; LUSC trans rs2727020 0.553 rs3862350 chr11:49595912 A/C cg15704280 chr7:45808275 SEPT13 -1.06 -20.24 -0.74 5.15e-60 Coronary artery disease; LUSC cis rs73198271 0.515 rs11779327 chr8:8624955 G/C cg01851573 chr8:8652454 MFHAS1 0.62 7.15 0.36 5.52e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.83 -0.39 6.48e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs656319 0.559 rs55683917 chr8:9976479 C/G cg21775007 chr8:11205619 TDH -0.44 -6.05 -0.31 3.98e-9 Myopia (pathological); LUSC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg23583168 chr7:148888333 NA -0.8 -13.39 -0.59 5.02e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9325144 0.600 rs7965877 chr12:38743697 G/T cg13010199 chr12:38710504 ALG10B 0.48 7.4 0.38 1.13e-12 Morning vs. evening chronotype; LUSC cis rs9309473 0.606 rs78941213 chr2:73885137 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -5.87 -0.31 1.06e-8 Metabolite levels; LUSC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.4 0.33 5.12e-10 Cerebrospinal P-tau181p levels; LUSC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 11.71 0.54 8.69e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2274273 0.624 rs7151581 chr14:55788445 A/G cg04306507 chr14:55594613 LGALS3 -0.49 -9.73 -0.47 7.06e-20 Protein biomarker; LUSC cis rs7584330 0.554 rs9646716 chr2:238443784 C/T cg14458575 chr2:238380390 NA 0.43 5.73 0.3 2.27e-8 Prostate cancer; LUSC cis rs10782582 0.609 rs56159153 chr1:76353498 T/G cg10523679 chr1:76189770 ACADM -0.45 -6.52 -0.34 2.53e-10 Daytime sleep phenotypes; LUSC cis rs7666738 0.546 rs62320963 chr4:98839297 A/G cg17366294 chr4:99064904 C4orf37 0.56 8.71 0.43 1.43e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs2204008 0.527 rs8189480 chr12:38345648 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.45 -0.33 3.94e-10 Bladder cancer; LUSC cis rs7589342 0.509 rs10168944 chr2:106386067 T/C cg09152813 chr2:106391379 NCK2 -0.37 -6.07 -0.32 3.43e-9 Addiction; LUSC cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg11102782 chr19:18549136 ISYNA1 -0.35 -6.69 -0.34 9.45e-11 Breast cancer; LUSC cis rs3862435 0.572 rs2601163 chr15:90908200 A/G cg22089800 chr15:90895588 ZNF774 -0.55 -6.08 -0.32 3.25e-9 Response to exercise (triglyceride level interaction); LUSC trans rs561341 1.000 rs546519 chr17:30297682 T/G cg27661571 chr11:113659931 NA -0.59 -7.18 -0.37 4.61e-12 Hip circumference adjusted for BMI; LUSC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg16624210 chr5:671434 TPPP 0.49 6.41 0.33 5.06e-10 Obesity-related traits; LUSC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg01879757 chr17:41196368 BRCA1 -0.48 -7.71 -0.39 1.49e-13 Menopause (age at onset); LUSC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg20607287 chr7:12443886 VWDE -0.63 -6.23 -0.32 1.44e-9 Coronary artery disease; LUSC cis rs1113500 0.862 rs3853494 chr1:108637334 G/A cg11967332 chr1:108735228 SLC25A24 0.39 5.97 0.31 6.23e-9 Growth-regulated protein alpha levels; LUSC cis rs7818345 0.874 rs12674938 chr8:19300813 A/G cg11303988 chr8:19266685 CSGALNACT1 0.39 7.37 0.37 1.36e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9549367 0.713 rs4907593 chr13:113830459 C/T cg00898013 chr13:113819073 PROZ 0.54 8.2 0.41 5.35e-15 Platelet distribution width; LUSC cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg05347473 chr6:146136440 FBXO30 0.53 8.91 0.44 3.27e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9302065 0.681 rs9524902 chr13:95963518 C/T cg24476569 chr13:95954382 ABCC4 -0.48 -7.81 -0.39 7.4e-14 Blood metabolite levels; LUSC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4683142 0.518 rs4682801 chr3:46021218 G/T cg19145607 chr3:45983792 CXCR6;FYCO1 0.36 5.96 0.31 6.3e-9 Methadone dose in opioid dependence; LUSC cis rs11676348 0.755 rs62183956 chr2:219046122 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.39 6.12 0.32 2.66e-9 Ulcerative colitis; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg16606324 chr3:10149918 C3orf24 0.71 9.96 0.48 1.2e-20 Alzheimer's disease; LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg26314531 chr2:26401878 FAM59B -0.72 -9.87 -0.48 2.4e-20 Gut microbiome composition (summer); LUSC cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg05025164 chr4:1340916 KIAA1530 0.42 6.38 0.33 5.92e-10 Obesity-related traits; LUSC trans rs7937682 0.814 rs1619652 chr11:111469757 G/A cg18187862 chr3:45730750 SACM1L 0.53 6.82 0.35 4.28e-11 Primary sclerosing cholangitis; LUSC cis rs4722585 0.533 rs2158359 chr7:26193309 A/C cg07876897 chr7:26191696 NFE2L3 -0.43 -6.3 -0.33 9.13e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs8017423 0.967 rs7146640 chr14:90720114 C/T cg14092571 chr14:90743983 NA 0.37 6.05 0.31 3.79e-9 Mortality in heart failure; LUSC cis rs8064299 0.655 rs12797 chr17:72766993 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.55 9.06 0.44 1.12e-17 Monocyte count; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.96 0.4 2.64e-14 Prudent dietary pattern; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg14004847 chr7:1930337 MAD1L1 -0.5 -7.67 -0.39 1.9e-13 Bipolar disorder and schizophrenia; LUSC cis rs4280164 0.551 rs2295300 chr14:24805117 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.56 -7.07 -0.36 9.27e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs4523957 0.928 rs749240 chr17:2186100 A/G cg16513277 chr17:2031491 SMG6 0.59 9.65 0.47 1.39e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs8030485 0.571 rs10775219 chr15:79443894 G/A cg17916960 chr15:79447300 NA 0.33 5.74 0.3 2.16e-8 Left ventricle wall thickness; LUSC cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg08999081 chr20:33150536 PIGU 0.53 10.54 0.5 1.32e-22 Glomerular filtration rate (creatinine); LUSC cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg22437258 chr11:111473054 SIK2 -0.5 -6.31 -0.33 9.1e-10 Primary sclerosing cholangitis; LUSC cis rs7940866 0.804 rs3910267 chr11:130810282 C/T cg12179176 chr11:130786555 SNX19 0.64 9.7 0.47 9.01e-20 Schizophrenia; LUSC trans rs453301 0.653 rs2956244 chr8:8885166 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.07 0.32 3.42e-9 Joint mobility (Beighton score); LUSC cis rs9443189 0.615 rs618239 chr6:76350038 A/G cg01950844 chr6:76311363 SENP6 0.67 6.69 0.34 9.16e-11 Prostate cancer; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg20849893 chr7:64541193 NA -0.48 -7.12 -0.36 6.81e-12 Calcium levels; LUSC cis rs1670533 1.000 rs10031302 chr4:1059664 G/A cg16405210 chr4:1374714 KIAA1530 -0.46 -5.67 -0.3 3.03e-8 Recombination rate (females); LUSC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs1981331 1.000 rs79694455 chr21:47983979 C/T cg23283320 chr21:48055893 PRMT2 1.12 8.03 0.4 1.68e-14 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg01802117 chr1:53393560 SCP2 0.38 6.21 0.32 1.53e-9 Monocyte count; LUSC cis rs508618 0.638 rs479200 chr1:231543780 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -6.8 -0.35 4.72e-11 Red blood cell count; LUSC cis rs7100689 0.577 rs2342813 chr10:82046302 T/G cg00277334 chr10:82204260 NA -0.42 -5.95 -0.31 6.8e-9 Post bronchodilator FEV1; LUSC cis rs67981189 0.593 rs12896829 chr14:71463676 G/C cg15816911 chr14:71606274 NA 0.34 5.99 0.31 5.41e-9 Schizophrenia; LUSC cis rs7107174 1.000 rs11237468 chr11:78072833 A/G cg02023728 chr11:77925099 USP35 0.47 7.06 0.36 9.75e-12 Testicular germ cell tumor; LUSC cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.27 0.49 1.06e-21 Schizophrenia; LUSC cis rs11608355 0.515 rs61941592 chr12:109930497 G/A cg05360138 chr12:110035743 NA 0.92 12.2 0.56 1.41e-28 Neuroticism; LUSC cis rs193541 0.632 rs400207 chr5:122318497 C/T cg19077854 chr5:122220652 SNX24 -0.4 -8.45 -0.42 9.27e-16 Glucose homeostasis traits; LUSC cis rs7089973 0.872 rs35622181 chr10:116631976 C/T cg23260525 chr10:116636907 FAM160B1 0.39 7.98 0.4 2.37e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7937682 0.924 rs12791699 chr11:111505880 T/C cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC cis rs7523273 0.526 rs2724375 chr1:207997973 C/A cg22525895 chr1:207977042 MIR29B2 -0.41 -6.74 -0.35 7.02e-11 Schizophrenia; LUSC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg14784868 chr12:69753453 YEATS4 0.91 16.11 0.66 1.33e-43 Cerebrospinal fluid biomarker levels; LUSC cis rs6543140 0.855 rs4851591 chr2:103077423 T/C cg09003973 chr2:102972529 NA 0.55 7.04 0.36 1.09e-11 Blood protein levels; LUSC cis rs7607369 0.609 rs13391398 chr2:219282429 A/G cg02176678 chr2:219576539 TTLL4 0.62 10.87 0.51 8.76e-24 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs8044995 0.563 rs7190134 chr16:68381516 A/G cg09835421 chr16:68378352 PRMT7 0.82 8.96 0.44 2.33e-17 Schizophrenia; LUSC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg11247378 chr22:39784982 NA -0.67 -13.7 -0.6 3.21e-34 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg19812747 chr11:111475976 SIK2 -0.57 -8.44 -0.42 9.47e-16 Primary sclerosing cholangitis; LUSC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg00933542 chr6:150070202 PCMT1 0.31 6.34 0.33 7.54e-10 Lung cancer; LUSC cis rs7739264 0.602 rs9350179 chr6:19764095 G/A cg02404759 chr6:19790362 NA -0.43 -6.79 -0.35 5.16e-11 Endometriosis; LUSC cis rs2282300 0.739 rs3858428 chr11:30296550 T/C cg25418670 chr11:30344373 C11orf46 0.64 9.09 0.45 9.01e-18 Morning vs. evening chronotype; LUSC cis rs701145 0.938 rs355776 chr3:154035626 A/T cg17054900 chr3:154042577 DHX36 0.84 8.81 0.43 7.07e-17 Coronary artery disease; LUSC cis rs9479482 0.967 rs61730071 chr6:150342232 G/A cg25797454 chr6:150327115 RAET1K 0.37 8.56 0.42 4.17e-16 Alopecia areata; LUSC trans rs61931739 0.817 rs7963318 chr12:34244929 C/G cg13010199 chr12:38710504 ALG10B -0.39 -6.26 -0.32 1.18e-9 Morning vs. evening chronotype; LUSC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg06634786 chr22:41940651 POLR3H -0.57 -6.91 -0.35 2.52e-11 Vitiligo; LUSC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg16447950 chr5:562315 NA -0.55 -7.64 -0.39 2.29e-13 Obesity-related traits; LUSC trans rs7824557 0.767 rs1897951 chr8:11169854 C/T cg15556689 chr8:8085844 FLJ10661 0.56 8.54 0.42 4.93e-16 Retinal vascular caliber; LUSC cis rs1577917 1.000 rs6933377 chr6:86705255 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.44 6.92 0.35 2.36e-11 Response to antipsychotic treatment; LUSC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg14552801 chr7:65878734 NA 0.46 6.58 0.34 1.79e-10 Aortic root size; LUSC cis rs2279817 0.863 rs2354291 chr1:18027554 G/T cg21791023 chr1:18019539 ARHGEF10L -0.42 -6.39 -0.33 5.62e-10 Neuroticism; LUSC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg18240062 chr17:79603768 NPLOC4 0.68 12.86 0.58 5.28e-31 Eye color traits; LUSC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.59 -0.38 3.21e-13 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg17366294 chr4:99064904 C4orf37 0.5 8.7 0.43 1.54e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1030268 0.607 rs34218501 chr7:133210375 G/A cg10665199 chr7:133106180 EXOC4 0.57 6.57 0.34 1.99e-10 Intelligence (multi-trait analysis); LUSC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08109568 chr15:31115862 NA -0.6 -8.31 -0.41 2.46e-15 Huntington's disease progression; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21528136 chr17:73901016 MRPL38 -0.5 -5.98 -0.31 5.7e-9 Bipolar disorder and schizophrenia; LUSC cis rs7178375 0.607 rs12903674 chr15:31194552 G/C cg03767031 chr15:31195708 MTMR15 0.81 6.46 0.33 3.64e-10 Hypertriglyceridemia; LUSC cis rs7408868 1.000 rs2074618 chr19:15276143 C/T cg14696996 chr19:15285081 NOTCH3 1.02 9.38 0.46 1.03e-18 Pulse pressure; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10886005 chr2:98612331 TMEM131 -0.41 -6.0 -0.31 5.03e-9 Electrocardiographic conduction measures; LUSC cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg23158103 chr7:148848205 ZNF398 -0.43 -6.72 -0.35 7.88e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26365885 chr17:64188403 CCDC46 -0.43 -6.53 -0.34 2.42e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg16680214 chr1:154839983 KCNN3 -0.52 -9.76 -0.47 5.77e-20 Prostate cancer; LUSC cis rs2130392 0.924 rs873687 chr4:185638853 G/A cg04058563 chr4:185651563 MLF1IP -0.41 -6.75 -0.35 6.6e-11 Kawasaki disease; LUSC cis rs6942756 0.747 rs691124 chr7:129098439 A/G cg02491457 chr7:128862824 NA -0.42 -5.97 -0.31 6.12e-9 White matter hyperintensity burden; LUSC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22590775 chr19:49891494 CCDC155 0.61 8.67 0.43 1.85e-16 Multiple sclerosis; LUSC cis rs4919087 0.561 rs61861820 chr10:98998974 G/A cg25902810 chr10:99078978 FRAT1 -0.42 -5.82 -0.3 1.41e-8 Monocyte count; LUSC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg05084668 chr3:125655381 ALG1L -0.49 -6.9 -0.35 2.55e-11 Blood pressure (smoking interaction); LUSC cis rs72781680 0.752 rs72796110 chr2:23905658 T/A cg20701182 chr2:24300061 SF3B14 0.73 7.05 0.36 1.06e-11 Lymphocyte counts; LUSC cis rs500891 0.525 rs1145901 chr6:84038605 T/C cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.15e-14 Platelet-derived growth factor BB levels; LUSC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg09650180 chr20:62225654 GMEB2 -0.66 -9.48 -0.46 4.74e-19 Glioblastoma; LUSC cis rs9790314 1.000 rs336569 chr3:161072346 T/G cg03342759 chr3:160939853 NMD3 -0.47 -7.98 -0.4 2.45e-14 Morning vs. evening chronotype; LUSC cis rs3791556 0.661 rs3791539 chr2:240102327 C/T cg03281426 chr2:240109471 HDAC4 0.45 6.62 0.34 1.43e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg23630131 chr7:65973040 NA 0.21 5.81 0.3 1.42e-8 Aortic root size; LUSC cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg07148914 chr20:33460835 GGT7 -0.52 -8.11 -0.41 1e-14 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC trans rs9886428 1.000 rs4831569 chr8:14121952 C/A cg11959399 chr20:741723 C20orf54 -0.4 -6.22 -0.32 1.48e-9 IgG glycosylation; LUSC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg18758796 chr5:131593413 PDLIM4 0.34 5.74 0.3 2.09e-8 Blood metabolite levels; LUSC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.09 -0.32 3.14e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs1171606 0.731 rs1171651 chr10:61449817 C/A cg14119616 chr11:17099403 RPS13 -0.41 -6.17 -0.32 1.94e-9 Acylcarnitine levels; LUSC cis rs4851254 0.579 rs78633727 chr2:100669457 T/C cg07810366 chr2:100720526 AFF3 -0.47 -6.21 -0.32 1.59e-9 Intelligence (multi-trait analysis); LUSC cis rs6456156 0.692 rs9457270 chr6:167512928 A/G cg06454157 chr6:167490870 NA -0.26 -5.88 -0.31 1.02e-8 Primary biliary cholangitis; LUSC cis rs9296092 0.538 rs7761464 chr6:33519417 C/A cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.59e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs10782582 0.593 rs1412717 chr1:76125471 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.16 -0.36 5.33e-12 Daytime sleep phenotypes; LUSC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs7829975 0.755 rs3789849 chr8:8687054 G/C cg15556689 chr8:8085844 FLJ10661 0.68 11.06 0.52 1.88e-24 Mood instability; LUSC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg04287289 chr16:89883240 FANCA 0.79 13.93 0.61 4.45e-35 Vitiligo; LUSC cis rs11190604 1.000 rs2489050 chr10:102350898 T/A cg07080220 chr10:102295463 HIF1AN 0.66 8.39 0.42 1.43e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2540226 0.816 rs13428837 chr2:39996457 C/T cg23576258 chr2:39999331 THUMPD2 0.34 5.79 0.3 1.66e-8 Personality dimensions; LUSC cis rs7829975 0.577 rs940030 chr8:8546928 A/G cg15556689 chr8:8085844 FLJ10661 -0.48 -6.9 -0.35 2.64e-11 Mood instability; LUSC cis rs1538970 0.924 rs12037201 chr1:45941349 G/T cg05343316 chr1:45956843 TESK2 0.68 9.18 0.45 4.76e-18 Platelet count; LUSC trans rs7757969 1.000 rs28566870 chr6:112118932 T/C cg27172877 chr11:124806777 HEPACAM 0.66 6.38 0.33 5.95e-10 Schizophrenia; LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg16405210 chr4:1374714 KIAA1530 0.55 8.21 0.41 4.98e-15 Obesity-related traits; LUSC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg16647868 chr5:131706066 SLC22A5 -0.35 -5.91 -0.31 8.33e-9 Blood metabolite levels; LUSC cis rs12579753 0.917 rs4842410 chr12:82219225 A/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.98 -0.31 5.63e-9 Resting heart rate; LUSC cis rs6681460 1.000 rs6659968 chr1:67123459 C/T cg02459107 chr1:67143332 SGIP1 0.47 8.95 0.44 2.48e-17 Presence of antiphospholipid antibodies; LUSC cis rs240764 0.658 rs6570922 chr6:101177262 C/T cg09795085 chr6:101329169 ASCC3 -0.45 -6.64 -0.34 1.25e-10 Neuroticism; LUSC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg04944784 chr2:26401820 FAM59B -0.68 -9.69 -0.47 9.62e-20 Gut microbiome composition (summer); LUSC trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs9403521 1.000 rs6907410 chr6:143995142 A/G cg18240653 chr6:144019428 PHACTR2 -0.51 -6.26 -0.32 1.19e-9 Obesity-related traits; LUSC cis rs2200578 1.000 rs72961173 chr2:99886868 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.48 0.33 3.26e-10 IgG glycosylation; LUSC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg26677194 chr12:130822605 PIWIL1 0.59 8.8 0.43 7.28e-17 Menopause (age at onset); LUSC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg08270630 chr22:50330655 NA -0.43 -6.45 -0.33 3.93e-10 Schizophrenia; LUSC cis rs12908161 0.960 rs62019463 chr15:85288087 G/A cg12863693 chr15:85201151 NMB 0.41 8.49 0.42 7.03e-16 Schizophrenia; LUSC cis rs9326248 0.581 rs10502222 chr11:116833730 C/T cg26566898 chr11:117069891 TAGLN 0.35 6.6 0.34 1.63e-10 Blood protein levels; LUSC cis rs3784262 0.935 rs4646563 chr15:58353335 T/C cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.99 -0.31 5.42e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg25072359 chr17:41440525 NA 0.57 8.3 0.41 2.54e-15 Menopause (age at onset); LUSC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg22903471 chr2:27725779 GCKR -0.39 -6.53 -0.34 2.42e-10 Total body bone mineral density; LUSC cis rs4722166 0.568 rs1880241 chr7:22759469 A/G cg05472934 chr7:22766657 IL6 0.37 6.25 0.32 1.26e-9 Lung cancer; LUSC cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.87 0.7 1.29e-50 Chronic sinus infection; LUSC cis rs2348418 0.681 rs10843207 chr12:28722862 A/G cg13890972 chr12:28721907 NA -0.39 -6.89 -0.35 2.81e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg19257562 chr1:2043853 PRKCZ 0.33 6.55 0.34 2.11e-10 Height; LUSC cis rs10843647 1.000 rs1533718 chr12:30341507 T/G cg12718339 chr12:29936407 TMTC1 -0.35 -5.72 -0.3 2.42e-8 Glucose homeostasis traits; LUSC cis rs12620999 0.941 rs13005377 chr2:238037759 T/C cg23555395 chr2:238036564 NA -0.53 -8.99 -0.44 1.82e-17 Systemic lupus erythematosus; LUSC cis rs9303280 0.936 rs907091 chr17:37921742 A/G cg19468946 chr17:37922297 IKZF3 -0.37 -5.78 -0.3 1.73e-8 Self-reported allergy; LUSC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.36 0.49 5.35e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg16325326 chr1:53192061 ZYG11B 0.74 12.76 0.57 1.16e-30 Monocyte count; LUSC cis rs16854884 1.000 rs1961542 chr3:143765503 G/A cg06585982 chr3:143692056 C3orf58 0.49 7.11 0.36 7.03e-12 Economic and political preferences (feminism/equality); LUSC cis rs6756513 0.509 rs11686934 chr2:70172116 C/T cg02498382 chr2:70120550 SNRNP27 0.25 6.1 0.32 2.86e-9 Breast cancer;Platelet count; LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg27572855 chr1:25598939 RHD 0.47 8.49 0.42 6.9e-16 Erythrocyte sedimentation rate; LUSC cis rs3931020 0.688 rs1051122 chr1:75190452 C/T cg00121533 chr1:75199117 CRYZ;TYW3 0.46 5.88 0.31 1.01e-8 Resistin levels; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg08736216 chr1:53307985 ZYG11A 0.3 6.16 0.32 2.04e-9 Monocyte count; LUSC cis rs4356932 1.000 rs7665152 chr4:76960205 T/G cg00809888 chr4:76862425 NAAA 0.36 5.95 0.31 6.75e-9 Blood protein levels; LUSC cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs7577696 0.924 rs6747488 chr2:32311284 C/T cg02381751 chr2:32503542 YIPF4 -0.4 -5.73 -0.3 2.22e-8 Inflammatory biomarkers; LUSC cis rs61931739 0.500 rs11053249 chr12:34518834 A/T cg06521331 chr12:34319734 NA -0.41 -6.3 -0.33 9.37e-10 Morning vs. evening chronotype; LUSC cis rs61931739 0.500 rs11053203 chr12:34456593 C/T cg06521331 chr12:34319734 NA -0.41 -6.33 -0.33 8.04e-10 Morning vs. evening chronotype; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11328022 chr20:34207568 SPAG4 -0.44 -6.19 -0.32 1.72e-9 Hepatitis; LUSC cis rs6500602 0.826 rs11076830 chr16:4460049 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 7.01 0.36 1.31e-11 Schizophrenia; LUSC cis rs977987 0.778 rs4887821 chr16:75398574 G/A cg03315344 chr16:75512273 CHST6 0.48 9.19 0.45 4.25e-18 Dupuytren's disease; LUSC cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg15997130 chr1:24165203 NA -0.46 -7.02 -0.36 1.21e-11 Immature fraction of reticulocytes; LUSC cis rs1577917 1.000 rs10944170 chr6:86685469 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.72 -0.35 7.69e-11 Response to antipsychotic treatment; LUSC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg00933542 chr6:150070202 PCMT1 0.31 6.45 0.33 3.87e-10 Lung cancer; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg11645453 chr3:52864694 ITIH4 0.29 6.72 0.35 7.72e-11 Electroencephalogram traits; LUSC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs7940866 0.874 rs1433979 chr11:130871617 G/A cg12179176 chr11:130786555 SNX19 0.62 9.66 0.47 1.23e-19 Schizophrenia; LUSC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg15839431 chr19:19639596 YJEFN3 0.43 6.1 0.32 2.86e-9 Tonsillectomy; LUSC cis rs7804356 0.953 rs28617235 chr7:26854671 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs7647973 1.000 rs974495 chr3:49400482 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.97 0.36 1.73e-11 Menarche (age at onset); LUSC cis rs6964587 0.626 rs4729011 chr7:91515419 G/A cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg18876405 chr7:65276391 NA 0.67 11.85 0.54 2.92e-27 Aortic root size; LUSC cis rs62283056 0.512 rs10028875 chr4:6283460 C/T cg00701064 chr4:6280414 WFS1 0.5 10.33 0.49 6.64e-22 Cisplatin-induced ototoxicity; LUSC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg22029157 chr1:209979665 IRF6 -0.71 -8.88 -0.44 4.17e-17 Cleft lip with or without cleft palate; LUSC cis rs4888262 0.545 rs58136167 chr16:74700628 G/A cg01733217 chr16:74700730 RFWD3 0.78 13.16 0.58 3.71e-32 Testicular germ cell tumor; LUSC cis rs11048434 0.736 rs11048337 chr12:9121330 C/A cg23795048 chr12:9217529 LOC144571 0.34 6.0 0.31 5.08e-9 Sjögren's syndrome; LUSC cis rs9486719 0.857 rs11759769 chr6:97065212 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -11.28 -0.53 3.32e-25 Migraine;Coronary artery disease; LUSC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg18350739 chr11:68623251 NA -0.38 -6.48 -0.33 3.36e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs911119 0.866 rs2405393 chr20:23569392 G/C cg16589663 chr20:23618590 CST3 0.63 7.33 0.37 1.74e-12 Chronic kidney disease; LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.84 0.35 3.69e-11 Platelet count; LUSC cis rs9527 0.615 rs7080462 chr10:104736699 T/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.6 -0.34 1.57e-10 Arsenic metabolism; LUSC cis rs933688 0.532 rs997737 chr5:90567031 C/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.51 -6.22 -0.32 1.51e-9 Smoking behavior; LUSC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg25039879 chr17:56429692 SUPT4H1 0.68 8.98 0.44 2.03e-17 Cognitive test performance; LUSC cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg15423357 chr2:25149977 NA -0.44 -8.93 -0.44 2.82e-17 Body mass index; LUSC cis rs7089973 0.872 rs10490908 chr10:116616162 T/C cg23260525 chr10:116636907 FAM160B1 0.4 8.26 0.41 3.52e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs422249 0.512 rs99780 chr11:61596633 C/T cg19610905 chr11:61596333 FADS2 -0.54 -8.23 -0.41 4.22e-15 Trans fatty acid levels; LUSC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs9549367 0.737 rs71446680 chr13:113894846 C/T cg00898013 chr13:113819073 PROZ -0.58 -8.41 -0.42 1.24e-15 Platelet distribution width; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27433451 chr1:51443332 NA -0.39 -6.04 -0.31 4.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs737008 0.960 rs949429 chr16:11376029 C/T cg00044050 chr16:11439710 C16orf75 -0.45 -6.69 -0.34 9.59e-11 Obesity-related traits; LUSC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg03396347 chr1:1875803 NA -0.54 -11.9 -0.55 1.87e-27 Body mass index; LUSC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg26441486 chr22:50317300 CRELD2 -0.51 -7.69 -0.39 1.65e-13 Schizophrenia; LUSC trans rs11098499 0.908 rs2017057 chr4:120257711 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.75 0.39 1.11e-13 Corneal astigmatism; LUSC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg14582100 chr15:45693742 SPATA5L1 0.59 10.79 0.51 1.81e-23 Homoarginine levels; LUSC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg15110403 chr19:17392923 ANKLE1 -0.51 -7.19 -0.37 4.16e-12 Systemic lupus erythematosus; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg04025307 chr7:1156635 C7orf50 0.38 6.06 0.31 3.72e-9 Longevity;Endometriosis; LUSC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg24549020 chr5:56110836 MAP3K1 0.5 6.06 0.31 3.63e-9 Initial pursuit acceleration; LUSC cis rs7119 0.679 rs12902698 chr15:77809010 A/C cg27398640 chr15:77910606 LINGO1 -0.3 -6.38 -0.33 5.83e-10 Type 2 diabetes; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg05025164 chr4:1340916 KIAA1530 -0.65 -10.13 -0.48 3.27e-21 Obesity-related traits; LUSC cis rs28655083 0.956 rs35848061 chr16:77101327 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.45 -6.79 -0.35 5e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs765787 0.530 rs55771002 chr15:45541566 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.04e-16 Uric acid levels; LUSC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg18230493 chr5:56204884 C5orf35 -0.97 -15.08 -0.64 1.48e-39 Initial pursuit acceleration; LUSC trans rs1376359 0.537 rs674479 chr1:103259724 C/T cg17154563 chr19:40477487 PSMC4 0.48 6.06 0.31 3.61e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 0.966 rs6083818 chr20:25346082 G/A cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs7100689 0.784 rs10887838 chr10:82161380 G/A cg01528321 chr10:82214614 TSPAN14 1.07 16.7 0.67 6.18e-46 Post bronchodilator FEV1; LUSC cis rs1982963 0.951 rs56834750 chr14:52509483 T/C cg10843707 chr14:52510701 NID2 -0.4 -6.92 -0.35 2.34e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6785206 0.667 rs2253125 chr3:128329793 T/C cg16766828 chr3:128327626 NA -0.62 -7.37 -0.37 1.39e-12 Lymphocyte percentage of white cells; LUSC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg01097406 chr16:89675127 NA 0.45 9.32 0.45 1.61e-18 Vitiligo; LUSC cis rs9677476 0.863 rs62197323 chr2:232063714 A/G cg07929768 chr2:232055508 NA 0.37 6.87 0.35 3.13e-11 Food antigen IgG levels; LUSC cis rs8060686 0.641 rs12448677 chr16:68209741 G/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.46 -6.53 -0.34 2.49e-10 Total body bone mineral density; LUSC cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.42 0.56 2.2e-29 Motion sickness; LUSC cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg25258033 chr6:167368657 RNASET2 0.39 6.3 0.33 9.49e-10 Crohn's disease; LUSC cis rs4072705 0.967 rs4838209 chr9:127528842 C/T cg13476313 chr9:127244764 NR5A1 0.3 5.67 0.3 3.13e-8 Menarche (age at onset); LUSC cis rs4730250 0.654 rs12705405 chr7:106792517 C/T cg02696742 chr7:106810147 HBP1 0.64 9.04 0.44 1.32e-17 Osteoarthritis; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg26304593 chr6:42947056 PEX6 -0.49 -7.33 -0.37 1.79e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4822044 0.617 rs13054514 chr22:42130383 A/G cg03806693 chr22:41940476 POLR3H 0.85 12.47 0.56 1.5e-29 Cannabis dependence symptom count; LUSC cis rs11031096 0.782 rs4910889 chr11:4153231 T/C cg18678763 chr11:4115507 RRM1 -0.5 -7.32 -0.37 1.81e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2573652 0.722 rs12595247 chr15:100541689 C/T cg09918751 chr15:100517450 ADAMTS17 -0.3 -5.82 -0.3 1.37e-8 Height; LUSC cis rs9837602 0.935 rs9810235 chr3:99736538 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.18 0.32 1.82e-9 Breast cancer; LUSC cis rs11864453 0.793 rs7197869 chr16:72079352 G/C cg01557791 chr16:72042693 DHODH -0.54 -7.78 -0.39 9.01e-14 Fibrinogen levels; LUSC cis rs7814319 0.966 rs6993518 chr8:97256341 T/A cg20787634 chr8:97240163 UQCRB -0.35 -6.12 -0.32 2.68e-9 Lung function (FVC); LUSC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg16414030 chr3:133502952 NA -0.42 -6.51 -0.34 2.81e-10 Iron status biomarkers; LUSC cis rs701145 0.556 rs355779 chr3:153977253 T/C cg10247383 chr3:153839028 SGEF -0.48 -5.83 -0.3 1.28e-8 Coronary artery disease; LUSC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg01448562 chr3:133502909 NA -0.8 -14.19 -0.61 4.14e-36 Iron status biomarkers; LUSC cis rs7220711 0.967 rs4792909 chr17:41798824 G/T cg26893861 chr17:41843967 DUSP3 0.42 5.93 0.31 7.56e-9 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.03 0.31 4.3e-9 Schizophrenia; LUSC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs6982240 0.514 rs10089212 chr8:142265380 T/A cg27411547 chr8:142287226 NA -0.47 -8.0 -0.4 2.12e-14 Tonsillectomy; LUSC cis rs2404602 0.692 rs4442773 chr15:77031633 T/C cg22467129 chr15:76604101 ETFA -0.44 -6.9 -0.35 2.61e-11 Blood metabolite levels; LUSC cis rs4903604 0.513 rs12880891 chr14:78035233 T/C cg18872420 chr14:78023429 SPTLC2 0.38 5.87 0.31 1.05e-8 Gut microbiome composition (winter); LUSC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg27121462 chr16:89883253 FANCA 0.54 8.61 0.43 2.84e-16 Vitiligo; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg08888203 chr3:10149979 C3orf24 0.65 9.24 0.45 3.01e-18 Alzheimer's disease; LUSC cis rs9420 0.961 rs77993055 chr11:57522840 C/T cg23127183 chr11:57508653 C11orf31 -0.57 -8.81 -0.43 6.86e-17 Schizophrenia; LUSC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg20933634 chr6:27740509 NA 0.42 5.89 0.31 9.49e-9 Parkinson's disease; LUSC cis rs9479482 0.935 rs5017315 chr6:150333574 C/T cg25797454 chr6:150327115 RAET1K 0.36 8.23 0.41 4.15e-15 Alopecia areata; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg04267008 chr7:1944627 MAD1L1 -0.54 -8.07 -0.4 1.3e-14 Bipolar disorder and schizophrenia; LUSC cis rs2692947 0.770 rs62153678 chr2:96558346 C/T cg23100626 chr2:96804247 ASTL 0.3 7.03 0.36 1.18e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6700896 0.500 rs6700421 chr1:66082135 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9611565 0.729 rs203320 chr22:41913477 T/C cg03806693 chr22:41940476 POLR3H -0.83 -11.79 -0.54 4.76e-27 Vitiligo; LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg05665937 chr4:1216051 CTBP1 -0.37 -5.86 -0.31 1.13e-8 Obesity-related traits; LUSC cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg21427119 chr20:30132790 HM13 -0.36 -5.67 -0.3 3.14e-8 Mean corpuscular hemoglobin; LUSC cis rs66716358 0.773 rs10769035 chr11:44318786 G/A cg02785814 chr11:44338707 NA 0.4 6.09 0.32 3.18e-9 Monobrow; LUSC cis rs11642862 0.901 rs77604316 chr16:30921487 G/A cg02466173 chr16:30829666 NA -0.62 -6.21 -0.32 1.59e-9 Tonsillectomy; LUSC cis rs4805272 0.512 rs8106166 chr19:29339578 A/G cg03161606 chr19:29218774 NA -0.55 -6.81 -0.35 4.58e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg03146154 chr1:46216737 IPP 0.54 7.78 0.39 9.14e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg24060327 chr5:131705240 SLC22A5 -0.52 -8.23 -0.41 4.37e-15 Acylcarnitine levels; LUSC cis rs8038465 0.615 rs11634399 chr15:73949210 A/G cg15420318 chr15:73925796 NPTN 0.62 10.73 0.51 2.75e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs950169 0.810 rs2879976 chr15:85109578 G/A cg17173187 chr15:85201210 NMB 0.36 6.59 0.34 1.72e-10 Schizophrenia; LUSC cis rs11209185 0.509 rs12142271 chr1:68446837 A/G cg22082780 chr1:68452167 NA 0.44 7.26 0.37 2.7e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg13319975 chr6:146136371 FBXO30 -0.66 -9.81 -0.47 4.07e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs11122272 0.735 rs2486741 chr1:231516450 G/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg23093090 chr10:104574429 C10orf26 -0.37 -6.87 -0.35 3.08e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg04369109 chr6:150039330 LATS1 -0.54 -8.06 -0.4 1.33e-14 Lung cancer; LUSC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.94 -0.44 2.75e-17 Breast cancer; LUSC cis rs698813 0.604 rs10865200 chr2:44482884 G/C cg00619915 chr2:44497795 NA -0.5 -7.02 -0.36 1.22e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs4820539 0.932 rs3788349 chr22:23467950 A/G cg21100191 chr22:23484243 RTDR1 0.91 15.73 0.65 3.99e-42 Bone mineral density; LUSC cis rs3820928 0.869 rs2396436 chr2:227795464 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.38e-13 Pulmonary function; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06713297 chr1:242011104 EXO1 0.45 6.73 0.35 7.55e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs748404 0.697 rs546722 chr15:43580819 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.43 6.02 0.31 4.7e-9 Lung cancer; LUSC cis rs6469656 1.000 rs4623456 chr8:117683771 A/G cg24004040 chr8:117650383 NA -0.43 -6.31 -0.33 9.04e-10 Colorectal cancer; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg04297258 chr16:88772664 RNF166;CTU2 0.51 6.71 0.34 8.29e-11 Cognitive function;Information processing speed; LUSC trans rs2018683 0.899 rs10479816 chr7:28978021 G/A cg19402173 chr7:128379420 CALU -0.55 -8.82 -0.43 6.31e-17 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.59 8.64 0.43 2.43e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17621444 0.522 rs10886577 chr10:121795683 T/C cg02041677 chr10:121771263 NA -0.35 -6.44 -0.33 4.19e-10 IgG glycosylation; LUSC cis rs10028773 0.546 rs13117947 chr4:120257060 A/G cg24375607 chr4:120327624 NA 0.52 8.07 0.4 1.28e-14 Educational attainment; LUSC cis rs4363385 0.588 rs6698361 chr1:153023184 T/G cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.46e-8 Inflammatory skin disease; LUSC cis rs9818758 0.607 rs9990153 chr3:49291883 C/T cg00383909 chr3:49044727 WDR6 1.09 10.67 0.5 4.6e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.38 -8.5 -0.42 6.61e-16 Cystic fibrosis severity; LUSC cis rs425277 0.917 rs78395918 chr1:2045876 G/A cg03732007 chr1:2071316 PRKCZ 0.46 7.33 0.37 1.77e-12 Height; LUSC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg02807482 chr3:125708958 NA -0.5 -6.28 -0.33 1.03e-9 Blood pressure (smoking interaction); LUSC cis rs8170 1.000 rs34084277 chr19:17387176 A/G cg04749549 chr19:17459798 NA -0.33 -5.81 -0.3 1.46e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC cis rs2398668 0.570 rs4721548 chr7:2330496 A/G cg08027265 chr7:2291960 NA -0.52 -8.97 -0.44 2.11e-17 Bipolar disorder and schizophrenia; LUSC cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg12011299 chr4:100065546 ADH4 0.71 10.76 0.51 2.23e-23 Smoking initiation; LUSC cis rs9309473 0.950 rs6756885 chr2:73805172 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -7.11 -0.36 7.12e-12 Metabolite levels; LUSC cis rs2839186 0.967 rs2839191 chr21:47695395 C/G cg05896524 chr21:47604654 C21orf56 0.42 6.14 0.32 2.35e-9 Testicular germ cell tumor; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg11965913 chr1:205819406 PM20D1 0.96 20.06 0.74 2.64e-59 Menarche (age at onset); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12679050 chr1:3773316 DFFB;KIAA0562 0.37 6.0 0.31 5.23e-9 Asthma; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg10862848 chr6:42927986 GNMT -0.28 -6.7 -0.34 8.86e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.52 -9.49 -0.46 4.69e-19 Bipolar disorder; LUSC cis rs7843479 0.601 rs11135764 chr8:21814004 A/G cg17168535 chr8:21777572 XPO7 0.85 15.57 0.65 1.7e-41 Mean corpuscular volume; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg21478123 chr6:1836850 GMDS 0.48 6.75 0.35 6.45e-11 Neuroticism; LUSC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.42 5.74 0.3 2.08e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg15423357 chr2:25149977 NA 0.46 9.24 0.45 3.07e-18 Body mass index; LUSC cis rs12579753 0.917 rs2401002 chr12:82215870 C/T cg07988820 chr12:82153109 PPFIA2 -0.44 -6.21 -0.32 1.56e-9 Resting heart rate; LUSC cis rs3733418 0.697 rs13111010 chr4:165956741 C/T cg11630554 chr4:165878136 TRIM61;C4orf39 -0.45 -5.79 -0.3 1.6e-8 Obesity-related traits; LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg01238044 chr22:24384105 GSTT1 0.73 12.42 0.56 2.19e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2078087 0.522 rs2477436 chr1:183209086 G/T cg13843938 chr1:183241246 NMNAT2 0.41 6.68 0.34 9.82e-11 Obesity-related traits; LUSC cis rs1577917 0.572 rs911927 chr6:86327860 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -9.52 -0.46 3.74e-19 Response to antipsychotic treatment; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.1 0.77 2.43e-67 Prudent dietary pattern; LUSC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs1185460 0.967 rs1784302 chr11:118940957 C/G cg01677386 chr11:118938358 VPS11 -0.48 -6.8 -0.35 4.93e-11 Coronary artery disease; LUSC cis rs12980942 1.000 rs1865053 chr19:41814412 T/C cg25627403 chr19:41769009 HNRNPUL1 0.56 6.03 0.31 4.3e-9 Coronary artery disease; LUSC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg02018176 chr4:1364513 KIAA1530 0.45 7.39 0.37 1.19e-12 Obesity-related traits; LUSC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 10.56 0.5 1.09e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs372883 0.506 rs2832301 chr21:30749712 G/A cg24692254 chr21:30365293 RNF160 0.68 10.73 0.51 2.77e-23 Pancreatic cancer; LUSC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg06481639 chr22:41940642 POLR3H -0.51 -6.15 -0.32 2.25e-9 Vitiligo; LUSC cis rs7189233 0.531 rs62048526 chr16:53511926 G/A cg09728985 chr16:53543985 NA -0.33 -6.21 -0.32 1.53e-9 Intelligence (multi-trait analysis); LUSC cis rs3850699 0.609 rs12763720 chr10:104241983 T/C cg05855489 chr10:104503620 C10orf26 0.69 9.25 0.45 2.76e-18 Prostate cancer; LUSC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg02487422 chr3:49467188 NICN1 0.48 7.63 0.39 2.46e-13 Resting heart rate; LUSC cis rs612683 0.694 rs6688364 chr1:101000874 G/A cg09408571 chr1:101003634 GPR88 0.32 5.95 0.31 6.87e-9 Breast cancer; LUSC cis rs7197653 0.667 rs16957831 chr16:68378341 C/T cg05110241 chr16:68378359 PRMT7 -0.76 -8.7 -0.43 1.59e-16 Magnesium levels; LUSC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg03433033 chr1:76189801 ACADM 0.8 12.86 0.58 5.1e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg13047869 chr3:10149882 C3orf24 0.65 9.49 0.46 4.69e-19 Alzheimer's disease; LUSC cis rs11098499 0.863 rs3775844 chr4:120428033 G/A cg09307838 chr4:120376055 NA 0.76 11.09 0.52 1.5e-24 Corneal astigmatism; LUSC trans rs11976180 0.569 rs12703565 chr7:143754401 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.65 -9.51 -0.46 3.93e-19 Obesity-related traits; LUSC cis rs2075671 0.903 rs62482249 chr7:100262357 C/A cg00334542 chr7:100209784 MOSPD3 -0.49 -5.74 -0.3 2.11e-8 Other erythrocyte phenotypes; LUSC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg18904891 chr8:8559673 CLDN23 0.55 7.58 0.38 3.34e-13 Obesity-related traits; LUSC cis rs6061231 0.518 rs639836 chr20:60926223 G/A cg22601191 chr20:60968625 CABLES2 -0.39 -6.45 -0.33 3.86e-10 Colorectal cancer; LUSC cis rs9910055 1.000 rs9910055 chr17:42283037 C/T cg19774624 chr17:42201019 HDAC5 -0.73 -10.52 -0.5 1.52e-22 Total body bone mineral density; LUSC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC trans rs61931739 0.534 rs10844800 chr12:34230734 A/G cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.35e-16 Morning vs. evening chronotype; LUSC cis rs6489882 0.934 rs1859330 chr12:113376388 G/A cg20102336 chr12:113376681 OAS3 -0.4 -6.01 -0.31 4.87e-9 Chronic lymphocytic leukemia; LUSC cis rs9527 0.545 rs7894588 chr10:104756030 A/T cg04362960 chr10:104952993 NT5C2 0.59 8.92 0.44 3.08e-17 Arsenic metabolism; LUSC trans rs7824557 0.767 rs2164272 chr8:11162496 A/C cg06636001 chr8:8085503 FLJ10661 0.51 7.66 0.39 2.06e-13 Retinal vascular caliber; LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.13 -0.52 1.09e-24 Alzheimer's disease; LUSC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg06238570 chr21:40685208 BRWD1 0.53 8.43 0.42 1.07e-15 Cognitive function; LUSC trans rs208515 0.525 rs1484577 chr6:66688397 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.01 14.02 0.61 1.94e-35 Exhaled nitric oxide levels; LUSC cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg22782873 chr19:19639568 YJEFN3 -0.48 -5.79 -0.3 1.64e-8 Bipolar disorder; LUSC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg17211192 chr8:82754475 SNX16 -0.59 -8.36 -0.42 1.66e-15 Diastolic blood pressure; LUSC trans rs6502050 0.731 rs9891378 chr17:80116035 T/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs12200560 0.505 rs211166 chr6:97068598 T/C cg06623918 chr6:96969491 KIAA0776 0.51 7.32 0.37 1.85e-12 Coronary heart disease; LUSC trans rs35110281 0.744 rs230646 chr21:44918788 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.8 0.43 7.26e-17 Mean corpuscular volume; LUSC cis rs12956009 0.583 rs35970525 chr18:44882625 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.01 0.31 4.97e-9 Educational attainment (years of education); LUSC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg15316289 chr22:50310904 ALG12;CRELD2 0.53 8.02 0.4 1.76e-14 Schizophrenia; LUSC cis rs2404602 0.647 rs7165053 chr15:76978918 A/G cg23625390 chr15:77176239 SCAPER -0.66 -10.15 -0.49 2.86e-21 Blood metabolite levels; LUSC cis rs7954584 0.504 rs10840633 chr12:122377511 A/T cg22618164 chr12:122356400 WDR66 0.63 9.11 0.45 7.88e-18 Mean corpuscular volume; LUSC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg18876405 chr7:65276391 NA -0.54 -8.46 -0.42 8.43e-16 Aortic root size; LUSC cis rs17685 0.796 rs3757594 chr7:75678644 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.91 0.4 3.75e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs17270561 0.609 rs9379786 chr6:25730255 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.06 0.36 9.8e-12 Rheumatoid arthritis; LUSC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10779751 0.734 rs6701726 chr1:11126941 C/T cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs7605827 0.897 rs6708187 chr2:15684964 T/A cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.32e-17 Educational attainment (years of education); LUSC cis rs7359276 1 rs7359276 chr15:78892661 C/T cg24631222 chr15:78858424 CHRNA5 -0.68 -9.48 -0.46 4.75e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg08270630 chr22:50330655 NA -0.42 -6.44 -0.33 4.24e-10 Schizophrenia; LUSC cis rs9303401 0.659 rs62081316 chr17:56781499 C/T cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs2019216 0.500 rs1356483 chr17:21934029 A/C cg22648282 chr17:21454238 C17orf51 -0.53 -7.91 -0.4 3.88e-14 Pelvic organ prolapse; LUSC trans rs7824557 0.767 rs17797443 chr8:11164012 T/C cg06636001 chr8:8085503 FLJ10661 0.51 7.74 0.39 1.21e-13 Retinal vascular caliber; LUSC cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg23029597 chr12:123009494 RSRC2 -0.73 -9.72 -0.47 7.8e-20 Body mass index; LUSC cis rs1023500 0.573 rs133382 chr22:42471774 C/T cg04733989 chr22:42467013 NAGA 0.61 9.5 0.46 4.27e-19 Schizophrenia; LUSC cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg10978503 chr1:24200527 CNR2 0.53 13.15 0.58 4.1e-32 Immature fraction of reticulocytes; LUSC cis rs9300255 0.639 rs1716171 chr12:123716376 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.94 -0.31 7.31e-9 Neutrophil percentage of white cells; LUSC trans rs7937682 0.632 rs4935811 chr11:111679262 C/T cg18187862 chr3:45730750 SACM1L -0.52 -6.33 -0.33 7.7e-10 Primary sclerosing cholangitis; LUSC cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg08873628 chr1:175162347 KIAA0040 0.39 5.7 0.3 2.59e-8 Alcohol dependence; LUSC trans rs208515 0.592 rs10944862 chr6:66674215 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.17 0.61 5.27e-36 Exhaled nitric oxide levels; LUSC cis rs12579753 0.879 rs7131927 chr12:82166313 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.39 -0.33 5.47e-10 Resting heart rate; LUSC cis rs9925964 0.687 rs12917722 chr16:30948397 A/G cg02466173 chr16:30829666 NA 0.39 7.37 0.37 1.34e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs16854884 0.837 rs4362712 chr3:143801076 G/A cg06585982 chr3:143692056 C3orf58 0.46 6.78 0.35 5.52e-11 Economic and political preferences (feminism/equality); LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg08219700 chr8:58056026 NA 0.63 8.13 0.41 8.37e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg22535103 chr8:58192502 C8orf71 -0.69 -7.28 -0.37 2.35e-12 Developmental language disorder (linguistic errors); LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg24813613 chr7:1882135 MAD1L1 -0.43 -7.21 -0.37 3.68e-12 Bipolar disorder and schizophrenia; LUSC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg17252645 chr8:143867129 LY6D 0.38 6.65 0.34 1.23e-10 Urinary tract infection frequency; LUSC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.7 11.69 0.54 1.1e-26 Menarche (age at onset); LUSC cis rs6700896 0.897 rs28480230 chr1:66124075 C/T cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3126085 0.778 rs10788828 chr1:152191879 G/A cg03465714 chr1:152285911 FLG -0.42 -5.79 -0.3 1.64e-8 Atopic dermatitis; LUSC cis rs6736093 1.000 rs7349221 chr2:112668341 A/G cg12686935 chr2:112915763 FBLN7 -0.35 -5.72 -0.3 2.41e-8 Coronary artery disease; LUSC cis rs9905704 0.628 rs2531735 chr17:56551139 A/G cg12560992 chr17:57184187 TRIM37 -0.5 -5.75 -0.3 2.01e-8 Testicular germ cell tumor; LUSC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.62 -5.96 -0.31 6.58e-9 Cerebrospinal P-tau181p levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19835839 chr12:120966954 COQ5 0.49 7.19 0.37 4.22e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs3942852 0.550 rs1113480 chr11:48058313 G/T cg15704280 chr7:45808275 SEPT13 -0.56 -6.94 -0.36 2.09e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs28374715 0.578 rs13313520 chr15:41629127 T/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -23.82 -0.79 5.59e-74 Ulcerative colitis; LUSC cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg19346786 chr7:2764209 NA -0.33 -6.01 -0.31 4.76e-9 Height; LUSC cis rs478304 0.903 rs12293022 chr11:65531698 C/T cg27068330 chr11:65405492 SIPA1 0.62 9.33 0.45 1.54e-18 Acne (severe); LUSC cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs9463078 0.528 rs12214778 chr6:44924412 A/G cg25276700 chr6:44698697 NA 0.28 5.78 0.3 1.69e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg22532475 chr10:104410764 TRIM8 0.28 5.7 0.3 2.65e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12922032 chr2:32582209 BIRC6 0.46 6.82 0.35 4.25e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9807989 0.839 rs3771166 chr2:102986222 G/A cg09003973 chr2:102972529 NA 0.44 6.04 0.31 4.11e-9 Asthma; LUSC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg06808227 chr14:105710500 BRF1 -0.66 -10.09 -0.48 4.5e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg11843238 chr5:131593191 PDLIM4 0.51 9.04 0.44 1.32e-17 Acylcarnitine levels; LUSC cis rs6087990 0.735 rs2424922 chr20:31386449 T/C cg13636640 chr20:31349939 DNMT3B 0.91 18.58 0.71 2.11e-53 Ulcerative colitis; LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.31 -0.41 2.42e-15 Gut microbiome composition (summer); LUSC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg25809561 chr17:30822961 MYO1D 0.45 7.53 0.38 4.63e-13 Schizophrenia; LUSC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.96e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs735860 0.737 rs2115564 chr6:53173482 C/A cg10236188 chr6:53219634 NA -0.38 -5.99 -0.31 5.32e-9 Glaucoma; LUSC cis rs4319547 0.698 rs4039670 chr12:122822655 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.35 -0.42 1.79e-15 Body mass index; LUSC cis rs2230307 0.536 rs575971 chr1:100546591 T/C cg24955406 chr1:100503596 HIAT1 0.59 6.4 0.33 5.37e-10 Carotid intima media thickness; LUSC cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg17366294 chr4:99064904 C4orf37 0.5 8.7 0.43 1.54e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg26384229 chr12:38710491 ALG10B 0.9 17.25 0.69 3.85e-48 Heart rate; LUSC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg09796270 chr17:17721594 SREBF1 -0.38 -6.33 -0.33 7.87e-10 Total body bone mineral density; LUSC cis rs1568889 0.838 rs11030265 chr11:28296168 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 12.97 0.58 1.94e-31 Bipolar disorder; LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg25767906 chr1:53392781 SCP2 -0.65 -12.85 -0.58 5.69e-31 Monocyte count; LUSC trans rs2228479 0.850 rs12599473 chr16:89827435 A/C cg24644049 chr4:85504048 CDS1 0.88 7.56 0.38 3.9e-13 Skin colour saturation; LUSC cis rs34421088 0.603 rs10086064 chr8:11583841 A/G cg00262122 chr8:11665843 FDFT1 0.41 6.16 0.32 2.03e-9 Neuroticism; LUSC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.35 0.33 7.17e-10 Hip circumference adjusted for BMI; LUSC cis rs10904908 0.829 rs359280 chr10:17319707 C/T cg01003015 chr10:17271136 VIM 0.4 5.93 0.31 7.77e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs4776059 0.958 rs35505902 chr15:52888493 A/G cg25063058 chr15:52860530 ARPP19 0.46 6.29 0.33 1.01e-9 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04058639 chr4:169930757 CBR4 0.43 6.61 0.34 1.57e-10 Triglycerides; LUSC cis rs7824557 0.736 rs35392635 chr8:11164349 G/C cg21293242 chr8:11204541 TDH 0.32 5.97 0.31 6.23e-9 Retinal vascular caliber; LUSC cis rs10186029 0.680 rs12694293 chr2:213937221 T/C cg08319019 chr2:214017104 IKZF2 0.55 8.02 0.4 1.75e-14 Systemic sclerosis; LUSC cis rs9902453 0.765 rs2628180 chr17:28101723 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.68 -0.54 1.16e-26 Coffee consumption (cups per day); LUSC cis rs9398803 0.865 rs7738135 chr6:126829981 G/A cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.97e-9 Male-pattern baldness; LUSC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg11764359 chr7:65958608 NA -0.58 -8.99 -0.44 1.87e-17 Aortic root size; LUSC trans rs9341835 0.518 rs2758237 chr6:64218297 G/A cg19533977 chr17:57719682 CLTC 0.33 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs12136530 0.727 rs4911998 chr1:19765834 C/T cg01832549 chr1:19774989 CAPZB -0.31 -5.7 -0.3 2.6e-8 Lead levels in blood; LUSC cis rs72634258 0.519 rs2071984 chr1:7928656 C/T cg26816564 chr1:7831052 VAMP3 0.61 7.96 0.4 2.8e-14 Inflammatory bowel disease; LUSC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs12493885 0.725 rs4679728 chr3:153732761 G/C cg17054900 chr3:154042577 DHX36 -0.7 -7.37 -0.37 1.32e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs898097 0.690 rs3785520 chr17:80895745 T/C cg15369054 chr17:80825471 TBCD -0.63 -9.18 -0.45 4.65e-18 Breast cancer; LUSC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg27494647 chr7:150038898 RARRES2 0.57 8.43 0.42 1.07e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs6982240 0.514 rs11778579 chr8:142261621 C/T cg27411547 chr8:142287226 NA -0.47 -7.97 -0.4 2.48e-14 Tonsillectomy; LUSC cis rs897984 0.542 rs11864806 chr16:31095204 G/C cg02466173 chr16:30829666 NA -0.5 -9.55 -0.46 2.91e-19 Dementia with Lewy bodies; LUSC cis rs4588572 0.606 rs2362828 chr5:77718835 C/T cg11547950 chr5:77652471 NA -0.45 -6.87 -0.35 3.08e-11 Triglycerides; LUSC cis rs7937682 0.889 rs7948236 chr11:111499933 C/A cg22437258 chr11:111473054 SIK2 0.53 7.21 0.37 3.69e-12 Primary sclerosing cholangitis; LUSC cis rs11098499 0.863 rs34868248 chr4:120442430 A/G cg24375607 chr4:120327624 NA 0.77 11.22 0.52 5.34e-25 Corneal astigmatism; LUSC cis rs12210905 0.688 rs12212348 chr6:27361242 T/C cg08851530 chr6:28072375 NA 0.94 6.3 0.33 9.63e-10 Hip circumference adjusted for BMI; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg27074985 chr4:111118232 ELOVL6 0.44 6.15 0.32 2.17e-9 Mosquito bite size; LUSC cis rs41271473 1.000 rs41271473 chr1:228880296 G/A cg10167378 chr1:228756711 NA 0.5 6.16 0.32 2.12e-9 Chronic lymphocytic leukemia; LUSC cis rs7523050 0.908 rs17621536 chr1:109396908 A/G cg08274380 chr1:109419600 GPSM2 0.87 9.52 0.46 3.5e-19 Fat distribution (HIV); LUSC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg26314531 chr2:26401878 FAM59B -0.66 -9.12 -0.45 7.39e-18 Gut microbiome composition (summer); LUSC cis rs9811920 0.809 rs6802817 chr3:99779264 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 5.84 0.3 1.25e-8 Axial length; LUSC trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg04842962 chr6:43655489 MRPS18A 0.9 13.3 0.59 1.15e-32 IgG glycosylation; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg25703541 chr22:24373054 LOC391322 -0.91 -14.88 -0.63 8.75e-39 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg06634786 chr22:41940651 POLR3H -0.52 -6.43 -0.33 4.45e-10 Vitiligo; LUSC cis rs11792861 0.926 rs118011482 chr9:111770626 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.6 8.62 0.43 2.75e-16 Menarche (age at onset); LUSC cis rs2692947 0.832 rs2438978 chr2:96679740 G/C cg22654517 chr2:96458247 NA 0.34 6.38 0.33 5.84e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1790761 0.505 rs6591256 chr11:67349899 A/G cg24690094 chr11:67383802 NA -0.3 -5.72 -0.3 2.37e-8 Mean corpuscular volume; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg08428129 chr22:19744239 TBX1 0.39 6.68 0.34 1e-10 Metabolite levels (Pyroglutamine); LUSC cis rs16976116 0.951 rs3809540 chr15:55489412 A/C cg11288833 chr15:55489084 RSL24D1 0.54 6.55 0.34 2.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg18758796 chr5:131593413 PDLIM4 0.34 5.84 0.3 1.23e-8 Blood metabolite levels; LUSC cis rs7605827 0.857 rs9973946 chr2:15631022 C/T cg19274914 chr2:15703543 NA 0.47 9.15 0.45 5.75e-18 Educational attainment (years of education); LUSC cis rs2439831 0.850 rs56909447 chr15:44137618 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.54 0.42 4.94e-16 Lung cancer in ever smokers; LUSC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg19901468 chr14:105411992 AHNAK2 -0.71 -12.52 -0.57 9.7e-30 Rheumatoid arthritis; LUSC cis rs7131987 0.650 rs7957339 chr12:29456495 T/C cg09582351 chr12:29534625 ERGIC2 -0.33 -6.72 -0.34 7.98e-11 QT interval; LUSC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg09367891 chr1:107599246 PRMT6 -0.54 -8.39 -0.42 1.39e-15 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs72772090 0.908 rs11750510 chr5:96042095 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -7.2 -0.37 3.93e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs1973993 0.567 rs2800433 chr1:96998126 T/A cg10631902 chr5:14652156 NA 0.47 7.66 0.39 2.08e-13 Weight; LUSC cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg20848291 chr7:100343083 ZAN 0.39 6.14 0.32 2.33e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs12980942 1.000 rs7257310 chr19:41827120 C/T cg25627403 chr19:41769009 HNRNPUL1 0.57 6.15 0.32 2.17e-9 Coronary artery disease; LUSC trans rs7618501 0.635 rs34080578 chr3:50026029 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.56 9.02 0.44 1.46e-17 Intelligence (multi-trait analysis); LUSC cis rs988712 0.672 rs12419948 chr11:27666984 T/A cg10635145 chr11:27742435 BDNF -0.46 -5.96 -0.31 6.27e-9 Obesity; LUSC cis rs2840044 1.000 rs225259 chr17:33958168 A/G cg05299278 chr17:33885742 SLFN14 0.3 6.14 0.32 2.29e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs10911232 0.507 rs10797814 chr1:182990929 C/A ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.94e-22 Hypertriglyceridemia; LUSC cis rs11158026 0.603 rs4335711 chr14:55470863 G/C cg04306507 chr14:55594613 LGALS3 0.39 7.12 0.36 6.46e-12 Parkinson's disease; LUSC cis rs7615316 1.000 rs7631313 chr3:142354408 A/G cg16271453 chr3:142027066 XRN1 -0.34 -5.88 -0.31 9.73e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg22638593 chr5:131593259 PDLIM4 -0.41 -5.89 -0.31 9.42e-9 Breast cancer; LUSC cis rs7100689 0.577 rs9420359 chr10:82054873 C/T cg00277334 chr10:82204260 NA -0.45 -6.26 -0.32 1.19e-9 Post bronchodilator FEV1; LUSC cis rs9815354 0.761 rs73083329 chr3:41927151 C/T cg03022575 chr3:42003672 ULK4 0.82 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs4947962 1.000 rs4947962 chr7:55075807 C/G cg23757825 chr7:55092271 EGFR 0.66 6.96 0.36 1.78e-11 Subjective response to lithium treatment; LUSC cis rs34375054 0.573 rs12831151 chr12:125656263 C/T cg25124228 chr12:125621409 AACS -0.52 -6.8 -0.35 4.95e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg04944784 chr2:26401820 FAM59B -0.7 -9.77 -0.47 5.51e-20 Gut microbiome composition (summer); LUSC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg09904177 chr6:26538194 HMGN4 -0.39 -5.68 -0.3 2.93e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2762353 0.902 rs1165199 chr6:25809087 C/T cg12310025 chr6:25882481 NA -0.43 -7.44 -0.38 8.82e-13 Blood metabolite levels; LUSC cis rs4343996 0.666 rs10257982 chr7:3334597 C/T cg21248987 chr7:3385318 SDK1 -0.37 -6.4 -0.33 5.17e-10 Motion sickness; LUSC cis rs2204008 0.537 rs11170128 chr12:38006632 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.28 0.49 1.05e-21 Bladder cancer; LUSC cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.88 0.44 4.05e-17 Motion sickness; LUSC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg08677398 chr8:58056175 NA 0.41 5.74 0.3 2.16e-8 Developmental language disorder (linguistic errors); LUSC cis rs7843479 0.582 rs7818254 chr8:21798316 C/T cg17168535 chr8:21777572 XPO7 0.84 15.57 0.65 1.71e-41 Mean corpuscular volume; LUSC cis rs7584330 0.955 rs6729659 chr2:238385126 T/C cg16989719 chr2:238392110 NA -0.41 -7.22 -0.37 3.45e-12 Prostate cancer; LUSC cis rs1215050 0.660 rs3864229 chr4:98714323 A/G cg05340658 chr4:99064831 C4orf37 0.38 5.65 0.3 3.41e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg11266682 chr4:10021025 SLC2A9 0.53 10.0 0.48 9.15e-21 Bone mineral density; LUSC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg17211192 chr8:82754475 SNX16 -0.58 -8.28 -0.41 2.93e-15 Diastolic blood pressure; LUSC cis rs926938 0.563 rs360655 chr1:115447867 T/C cg01522456 chr1:115632236 TSPAN2 -0.41 -6.28 -0.32 1.05e-9 Autism; LUSC cis rs10203711 0.705 rs4663946 chr2:239610287 C/T cg14580085 chr2:239553406 NA -0.4 -6.65 -0.34 1.18e-10 Lobe attachment (rater-scored or self-reported); LUSC trans rs8002861 0.664 rs2184882 chr13:44450346 C/T cg12856521 chr11:46389249 DGKZ 0.42 6.54 0.34 2.31e-10 Leprosy; LUSC cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg06784218 chr1:46089804 CCDC17 -0.52 -9.87 -0.48 2.51e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs11122272 0.735 rs2739515 chr1:231514681 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg15790184 chr11:494944 RNH1 0.42 6.21 0.32 1.61e-9 Systemic lupus erythematosus; LUSC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg12310025 chr6:25882481 NA 0.63 10.55 0.5 1.17e-22 Blood metabolite levels; LUSC cis rs3771570 1.000 rs62190367 chr2:242376276 G/A cg21155796 chr2:242212141 HDLBP 0.61 6.71 0.34 8.57e-11 Prostate cancer; LUSC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg02187348 chr16:89574699 SPG7 -0.51 -8.12 -0.41 9.09e-15 Multiple myeloma (IgH translocation); LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.9 0.44 3.49e-17 Prudent dietary pattern; LUSC cis rs2274273 0.870 rs17741542 chr14:55805861 A/G cg04306507 chr14:55594613 LGALS3 -0.54 -12.12 -0.55 2.94e-28 Protein biomarker; LUSC cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7927592 0.546 rs554734 chr11:68192518 T/G cg20283391 chr11:68216788 NA -0.52 -7.19 -0.37 4.15e-12 Total body bone mineral density; LUSC cis rs4700695 0.641 rs386949 chr5:65231061 G/A cg21114390 chr5:65439923 SFRS12 0.52 5.66 0.3 3.21e-8 Facial morphology (factor 19); LUSC cis rs12541635 0.967 rs4734896 chr8:107075454 T/C cg10147462 chr8:107024639 NA -0.48 -8.62 -0.43 2.66e-16 Age of smoking initiation; LUSC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg19257562 chr1:2043853 PRKCZ 0.32 6.46 0.33 3.77e-10 Height; LUSC cis rs7589342 0.929 rs12053259 chr2:106428720 G/A cg14210321 chr2:106509881 NCK2 -0.55 -8.27 -0.41 3.26e-15 Addiction; LUSC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg04546413 chr19:29218101 NA 0.71 11.91 0.55 1.64e-27 Methadone dose in opioid dependence; LUSC trans rs28595532 0.702 rs72670238 chr4:119322751 C/T cg26518628 chr1:97050305 NA -0.76 -5.95 -0.31 6.67e-9 Cannabis dependence symptom count; LUSC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg08847533 chr14:75593920 NEK9 -0.84 -15.15 -0.64 8.06e-40 Height; LUSC cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs3806843 1.000 rs10477034 chr5:140169730 A/G cg19875535 chr5:140030758 IK 0.51 8.36 0.42 1.76e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg03433033 chr1:76189801 ACADM 0.77 11.37 0.53 1.52e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.78 0.39 9.04e-14 Gut microbiome composition (summer); LUSC cis rs6906287 0.647 rs12211576 chr6:118872080 G/A cg21191810 chr6:118973309 C6orf204 0.33 6.04 0.31 4.16e-9 Electrocardiographic conduction measures; LUSC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.69 0.54 1.11e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs611744 0.870 rs613179 chr8:109166006 G/A cg18478394 chr8:109455254 TTC35 0.42 6.32 0.33 8.15e-10 Dupuytren's disease; LUSC cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg12573674 chr2:1569213 NA -0.49 -5.74 -0.3 2.16e-8 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs6542838 0.597 rs35107109 chr2:99386210 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.23 -0.32 1.44e-9 Fear of minor pain; LUSC cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.78 11.08 0.52 1.61e-24 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2153904 0.793 rs1772145 chr1:205695695 C/T cg07167872 chr1:205819463 PM20D1 0.45 5.71 0.3 2.51e-8 Prostate-specific antigen levels; LUSC cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.65 8.48 0.42 7.52e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs31872 0.520 rs246053 chr5:140326290 T/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Visceral adipose tissue adjusted for BMI; LUSC cis rs7582180 0.676 rs1437969 chr2:100983482 A/C cg08017756 chr2:100939284 LONRF2 -0.44 -8.42 -0.42 1.16e-15 Intelligence (multi-trait analysis); LUSC cis rs12711979 0.765 rs897069 chr2:3818947 C/T cg17052675 chr2:3827356 NA 0.57 11.27 0.52 3.42e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg00316803 chr15:76480434 C15orf27 -0.39 -6.73 -0.35 7.24e-11 Blood metabolite levels; LUSC cis rs2011503 0.882 rs10407933 chr19:19364319 A/G cg11244672 chr19:19639970 YJEFN3 -0.54 -6.59 -0.34 1.76e-10 Bipolar disorder; LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg18765753 chr7:1198926 ZFAND2A -0.57 -10.73 -0.51 2.78e-23 Longevity;Endometriosis; LUSC cis rs10769945 0.679 rs2137322 chr11:1917354 A/G cg06197492 chr11:2016605 H19 -0.4 -6.93 -0.35 2.14e-11 DNA methylation (variation); LUSC cis rs4787491 0.679 rs12933575 chr16:30022564 A/G cg06326092 chr16:30034487 C16orf92 0.23 5.68 0.3 2.89e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg06784218 chr1:46089804 CCDC17 0.35 6.04 0.31 4.14e-9 Platelet count; LUSC cis rs1348850 0.958 rs4893965 chr2:178463852 G/T cg22681709 chr2:178499509 PDE11A -0.48 -8.71 -0.43 1.42e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -5.89 -0.31 9.45e-9 Platelet count; LUSC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg07716408 chr11:68623521 NA -0.32 -6.35 -0.33 6.83e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2290416 0.792 rs62522167 chr8:144678034 G/A cg08017634 chr8:144659831 NAPRT1 0.72 6.17 0.32 2.03e-9 Attention deficit hyperactivity disorder; LUSC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg15921436 chr17:44337874 NA 0.72 10.98 0.52 3.6e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg16414030 chr3:133502952 NA 0.53 8.84 0.44 5.47e-17 Iron status biomarkers; LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg22920501 chr2:26401640 FAM59B -0.79 -11.61 -0.54 2.05e-26 Gut microbiome composition (summer); LUSC cis rs10743315 0.643 rs4077883 chr12:19333359 C/A cg02471346 chr12:19282374 PLEKHA5 0.66 6.65 0.34 1.16e-10 Gut microbiota (bacterial taxa); LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg11843238 chr5:131593191 PDLIM4 0.42 6.99 0.36 1.52e-11 Acylcarnitine levels; LUSC cis rs4363385 0.588 rs12082627 chr1:153023650 G/A cg00922841 chr1:152955080 SPRR1A -0.36 -5.95 -0.31 6.82e-9 Inflammatory skin disease; LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.02 0.31 4.51e-9 Schizophrenia; LUSC cis rs8141529 0.732 rs3788409 chr22:29198151 T/G cg15103426 chr22:29168792 CCDC117 0.58 8.11 0.41 9.78e-15 Lymphocyte counts; LUSC cis rs12410462 0.582 rs12408978 chr1:227596235 A/T cg10327440 chr1:227177885 CDC42BPA 0.64 6.24 0.32 1.31e-9 Major depressive disorder; LUSC cis rs7246657 0.943 rs7258692 chr19:37818829 C/A cg23950597 chr19:37808831 NA -0.63 -7.58 -0.38 3.49e-13 Coronary artery calcification; LUSC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg03233332 chr7:66118400 NA 0.43 6.21 0.32 1.59e-9 Aortic root size; LUSC cis rs425277 1.000 rs262641 chr1:2104981 C/T cg24578937 chr1:2090814 PRKCZ -0.59 -13.8 -0.6 1.37e-34 Height; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26189035 chr5:180661257 TRIM41 -0.4 -6.12 -0.32 2.67e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs2562456 0.793 rs7259396 chr19:21523463 G/A cg00806126 chr19:22604979 ZNF98 -0.43 -6.21 -0.32 1.54e-9 Pain; LUSC cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg24130564 chr14:104152367 KLC1 -0.42 -6.06 -0.31 3.71e-9 Body mass index; LUSC cis rs8062405 1.000 rs80275162 chr16:28863517 T/A cg09754948 chr16:28834200 ATXN2L 0.41 5.84 0.3 1.25e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs356992 1.000 rs356992 chr2:60753593 C/G cg08426369 chr2:60753602 BCL11A 0.46 6.6 0.34 1.59e-10 Educational attainment (years of education); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20376421 chr12:56546193 MYL6B -0.4 -6.33 -0.33 7.81e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9341808 0.667 rs806783 chr6:80942943 A/C cg08355045 chr6:80787529 NA -0.4 -6.78 -0.35 5.53e-11 Sitting height ratio; LUSC cis rs9283706 0.689 rs6889240 chr5:66320940 A/G cg11590213 chr5:66331682 MAST4 0.5 7.28 0.37 2.47e-12 Coronary artery disease; LUSC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg24209194 chr3:40518798 ZNF619 0.45 6.26 0.32 1.21e-9 Renal cell carcinoma; LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg08027265 chr7:2291960 NA -0.37 -6.1 -0.32 2.98e-9 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg25767906 chr1:53392781 SCP2 0.39 6.68 0.34 9.86e-11 Monocyte count; LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg05234568 chr11:5960015 NA -0.6 -8.64 -0.43 2.43e-16 DNA methylation (variation); LUSC cis rs3770081 0.590 rs57367442 chr2:86453398 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.07 -7.19 -0.37 4.25e-12 Facial emotion recognition (sad faces); LUSC cis rs599083 0.530 rs576118 chr11:68177708 C/T cg01657329 chr11:68192670 LRP5 0.47 6.15 0.32 2.27e-9 Bone mineral density (spine); LUSC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg11663144 chr21:46675770 NA -0.39 -6.29 -0.33 9.82e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg00033643 chr7:134001901 SLC35B4 0.46 7.18 0.37 4.65e-12 Mean platelet volume; LUSC trans rs61931739 0.500 rs7311302 chr12:34557211 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs4631830 0.863 rs2843550 chr10:51521452 C/T cg20129853 chr10:51489980 NA -0.32 -6.39 -0.33 5.63e-10 Prostate-specific antigen levels; LUSC cis rs713477 0.967 rs4901570 chr14:55915249 T/C cg13175173 chr14:55914753 NA -0.3 -6.4 -0.33 5.2e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg05785598 chr3:49045655 WDR6 0.37 6.3 0.33 9.28e-10 Parkinson's disease; LUSC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg00343986 chr7:65444356 GUSB -0.38 -5.73 -0.3 2.29e-8 Aortic root size; LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.67 0.3 3.08e-8 Menopause (age at onset); LUSC cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg23711669 chr6:146136114 FBXO30 0.8 14.41 0.62 6.03e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.59 0.38 3.24e-13 Bipolar disorder; LUSC trans rs6598955 0.671 rs7544 chr1:26607726 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.53 -0.42 5.13e-16 Obesity-related traits; LUSC cis rs7605827 0.897 rs6431715 chr2:15717917 C/A cg19274914 chr2:15703543 NA 0.46 8.88 0.44 4.13e-17 Educational attainment (years of education); LUSC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.82 -0.39 6.91e-14 Personality dimensions; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg09352202 chr2:102314757 MAP4K4 0.47 5.96 0.31 6.55e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.23 -0.37 3.4e-12 Alzheimer's disease (late onset); LUSC cis rs13089785 0.965 rs12493045 chr3:123620718 C/A cg02012769 chr3:123398346 MYLK 0.32 5.95 0.31 6.78e-9 Intelligence (multi-trait analysis); LUSC cis rs3862435 0.666 rs2601202 chr15:90958089 G/A cg22089800 chr15:90895588 ZNF774 0.59 6.4 0.33 5.17e-10 Response to exercise (triglyceride level interaction); LUSC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg23887609 chr12:130822674 PIWIL1 0.48 7.08 0.36 8.43e-12 Menopause (age at onset); LUSC cis rs17102423 0.623 rs2898862 chr14:65612144 G/A cg11161011 chr14:65562177 MAX -0.63 -8.76 -0.43 1e-16 Obesity-related traits; LUSC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg11752832 chr7:134001865 SLC35B4 0.53 8.18 0.41 5.88e-15 Mean platelet volume; LUSC cis rs12148488 0.966 rs12899062 chr15:75347641 A/C cg09165964 chr15:75287851 SCAMP5 -0.45 -6.63 -0.34 1.34e-10 Caffeine consumption; LUSC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg10057126 chr4:77819792 ANKRD56 0.53 7.74 0.39 1.19e-13 Emphysema distribution in smoking; LUSC cis rs1865760 0.927 rs6915834 chr6:25935427 A/C cg16482183 chr6:26056742 HIST1H1C 0.45 6.46 0.33 3.65e-10 Height; LUSC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg19920283 chr7:105172520 RINT1 0.58 6.25 0.32 1.25e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg00071950 chr4:10020882 SLC2A9 0.64 10.93 0.51 5.65e-24 Bone mineral density; LUSC cis rs17407555 0.606 rs59871456 chr4:10014441 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -6.24 -0.32 1.3e-9 Schizophrenia (age at onset); LUSC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg10356904 chr22:49881777 NA -0.32 -7.02 -0.36 1.21e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg02269571 chr22:50332266 NA -0.58 -8.72 -0.43 1.33e-16 Schizophrenia; LUSC cis rs6500395 0.962 rs17826468 chr16:48568271 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.19 0.32 1.72e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7818345 0.967 rs35029660 chr8:19308126 T/C cg11303988 chr8:19266685 CSGALNACT1 0.36 6.63 0.34 1.32e-10 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg12432903 chr7:1882776 MAD1L1 -0.5 -8.47 -0.42 7.86e-16 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.875 rs2777479 chr6:146309178 C/A cg23711669 chr6:146136114 FBXO30 0.85 15.16 0.64 6.93e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467711 0.606 rs34273322 chr6:26415409 T/A cg09904177 chr6:26538194 HMGN4 -0.73 -6.73 -0.35 7.34e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs10782582 0.609 rs5745410 chr1:76314356 C/A cg03433033 chr1:76189801 ACADM -0.43 -6.39 -0.33 5.51e-10 Daytime sleep phenotypes; LUSC cis rs4076764 0.522 rs4265409 chr1:163414559 C/T cg06092702 chr1:163392909 NA -0.37 -6.45 -0.33 3.91e-10 Motion sickness; LUSC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg07507251 chr3:52567010 NT5DC2 0.34 6.61 0.34 1.5e-10 Bipolar disorder; LUSC cis rs9287719 0.967 rs728134 chr2:10745187 A/G cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.06 0.66 2.05e-43 Platelet count; LUSC cis rs2481665 0.740 rs2457831 chr1:62633581 C/T cg18591186 chr1:62594603 INADL 0.39 6.17 0.32 1.95e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs240764 0.658 rs12210255 chr6:101187540 G/C cg09795085 chr6:101329169 ASCC3 -0.45 -6.44 -0.33 4.08e-10 Neuroticism; LUSC cis rs10207628 0.738 rs7575209 chr2:127884123 A/C cg06223080 chr2:127868745 NA 0.39 6.8 0.35 4.77e-11 Psychosis and Alzheimer's disease; LUSC cis rs10791323 0.569 rs11223609 chr11:133741766 C/T cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.83 0.47 3.52e-20 Major depressive disorder; LUSC cis rs6964587 1.000 rs28584017 chr7:91719168 G/A cg22709100 chr7:91322751 NA 0.4 5.85 0.3 1.17e-8 Breast cancer; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg15242686 chr22:24348715 GSTTP1 0.43 6.46 0.33 3.6e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg04518342 chr5:131593106 PDLIM4 0.42 8.07 0.4 1.3e-14 Blood metabolite levels; LUSC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10782582 0.593 rs12142247 chr1:76235746 C/T cg10523679 chr1:76189770 ACADM -0.48 -7.13 -0.36 6.37e-12 Daytime sleep phenotypes; LUSC cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg09658497 chr7:2847517 GNA12 -0.33 -5.91 -0.31 8.53e-9 Height; LUSC cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg26384229 chr12:38710491 ALG10B -0.83 -15.22 -0.64 4.25e-40 Heart rate; LUSC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg01416388 chr22:39784598 NA -0.46 -7.59 -0.38 3.28e-13 Intelligence (multi-trait analysis); LUSC cis rs12545109 0.800 rs1467125 chr8:57418638 C/T cg09654669 chr8:57350985 NA -0.52 -6.7 -0.34 8.66e-11 Obesity-related traits; LUSC cis rs3738772 0.633 rs2483789 chr1:110053945 G/T cg08367326 chr1:110052010 AMIGO1 -0.49 -7.1 -0.36 7.58e-12 Intelligence (multi-trait analysis); LUSC cis rs9296095 1.000 rs5745568 chr6:33548394 G/T cg14003231 chr6:33640908 ITPR3 0.46 6.99 0.36 1.51e-11 Platelet count; LUSC cis rs8077889 0.672 rs3785810 chr17:41850689 C/G cg26893861 chr17:41843967 DUSP3 1.09 23.59 0.79 4.2e-73 Triglycerides; LUSC cis rs11122272 0.735 rs2749723 chr1:231493302 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.67 -10.37 -0.49 4.82e-22 Hemoglobin concentration; LUSC cis rs11122272 0.735 rs2009873 chr1:231499236 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.01 -0.48 8.34e-21 Hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16645584 chr1:59247487 JUN 0.46 7.17 0.37 4.77e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg23114746 chr17:47492438 PHB 0.46 6.21 0.32 1.61e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg05855489 chr10:104503620 C10orf26 -0.71 -10.0 -0.48 8.76e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00923919 chr22:26879581 HPS4;SRRD 0.41 6.08 0.32 3.28e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4969178 1.000 rs4969178 chr17:76388202 C/T cg05887092 chr17:76393375 PGS1 -0.47 -8.24 -0.41 4.03e-15 HDL cholesterol levels; LUSC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg24829409 chr8:58192753 C8orf71 0.55 5.97 0.31 6.02e-9 Developmental language disorder (linguistic errors); LUSC trans rs62238980 0.614 rs17683011 chr22:32445946 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs7560272 0.538 rs12052539 chr2:73937153 C/T cg20560298 chr2:73613845 ALMS1 -0.4 -6.13 -0.32 2.53e-9 Schizophrenia; LUSC cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg06271696 chr7:157225062 NA -0.42 -8.2 -0.41 5.18e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs501916 0.796 rs628501 chr15:48027328 C/G cg16110827 chr15:48056943 SEMA6D -0.43 -6.7 -0.34 8.85e-11 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg12516959 chr21:47718080 NA -0.37 -5.87 -0.31 1.07e-8 Testicular germ cell tumor; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19493827 chr11:118966130 H2AFX 0.4 6.14 0.32 2.32e-9 Asthma; LUSC cis rs6750795 0.870 rs6754952 chr2:232381245 G/T cg19187155 chr2:232395269 NMUR1 -0.93 -17.34 -0.69 1.81e-48 Height; LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg04455712 chr21:45112962 RRP1B 0.5 9.4 0.46 8.91e-19 Mean corpuscular volume; LUSC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.24 -0.73 4.98e-56 Height; LUSC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg01973587 chr1:228161476 NA -0.4 -7.24 -0.37 3.09e-12 Diastolic blood pressure; LUSC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg18876405 chr7:65276391 NA 0.56 8.84 0.44 5.64e-17 Aortic root size; LUSC cis rs748404 0.697 rs554001 chr15:43551919 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.43 6.05 0.31 3.91e-9 Lung cancer; LUSC trans rs11148252 0.553 rs2147692 chr13:53287023 C/G cg18335740 chr13:41363409 SLC25A15 0.76 13.95 0.61 3.58e-35 Lewy body disease; LUSC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg22800045 chr5:56110881 MAP3K1 0.77 9.99 0.48 9.62e-21 Initial pursuit acceleration; LUSC trans rs7681440 0.874 rs1372522 chr4:90765280 A/G cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC trans rs61931739 0.500 rs11053268 chr12:34545121 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs11792861 0.926 rs72607173 chr9:111879398 T/G cg13535736 chr9:111863775 C9orf5 -0.37 -6.15 -0.32 2.17e-9 Menarche (age at onset); LUSC cis rs7615952 0.673 rs34209763 chr3:125599595 G/A cg05084668 chr3:125655381 ALG1L -0.83 -11.71 -0.54 9.28e-27 Blood pressure (smoking interaction); LUSC cis rs2882667 0.690 rs288028 chr5:138221989 C/G cg04439458 chr5:138467593 SIL1 -0.42 -7.71 -0.39 1.48e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg19077165 chr18:44547161 KATNAL2 -0.4 -6.03 -0.31 4.39e-9 Personality dimensions; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg03188948 chr7:1209495 NA 0.41 6.14 0.32 2.34e-9 Longevity;Endometriosis; LUSC trans rs561341 0.882 rs28649357 chr17:30367190 A/G cg20587970 chr11:113659929 NA -1.2 -16.46 -0.67 5.34e-45 Hip circumference adjusted for BMI; LUSC cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg24130564 chr14:104152367 KLC1 -0.47 -6.82 -0.35 4.31e-11 Intelligence (multi-trait analysis); LUSC cis rs9311676 0.681 rs4681846 chr3:58332543 T/C cg26110898 chr3:58419937 PDHB -0.43 -6.96 -0.36 1.85e-11 Systemic lupus erythematosus; LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.67 0.6 4.29e-34 Platelet count; LUSC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg12963246 chr6:28129442 ZNF389 0.53 7.35 0.37 1.52e-12 Depression; LUSC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg03188948 chr7:1209495 NA 0.44 6.01 0.31 4.93e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs12190007 0.508 rs6605538 chr6:169731432 G/A cg16388071 chr6:169726476 NA 0.39 6.34 0.33 7.31e-10 Obesity-related traits; LUSC cis rs4664304 0.900 rs62176692 chr2:160743463 C/T cg03641300 chr2:160917029 PLA2R1 -0.4 -6.42 -0.33 4.63e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs1325195 0.881 rs3210839 chr1:179069429 C/T cg11624085 chr17:8464688 MYH10 -0.44 -7.03 -0.36 1.2e-11 IgE grass sensitization; LUSC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg03289416 chr15:75166202 SCAMP2 0.44 6.81 0.35 4.49e-11 Breast cancer; LUSC cis rs17030434 0.906 rs12643219 chr4:154670798 T/C cg14289246 chr4:154710475 SFRP2 -0.48 -6.39 -0.33 5.52e-10 Electrocardiographic conduction measures; LUSC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs9747201 0.926 rs34153075 chr17:80135728 C/A cg07393940 chr7:158741817 NA -0.53 -8.69 -0.43 1.68e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs908922 0.887 rs7535188 chr1:152475899 G/A cg20991723 chr1:152506922 NA 0.54 9.49 0.46 4.58e-19 Hair morphology; LUSC trans rs7395662 0.548 rs4882000 chr11:48546496 A/G cg15704280 chr7:45808275 SEPT13 -0.46 -6.34 -0.33 7.64e-10 HDL cholesterol; LUSC cis rs9341835 0.772 rs9344090 chr6:64135830 G/A cg03326410 chr6:64151739 NA -0.38 -6.26 -0.32 1.15e-9 Schizophrenia; LUSC cis rs11098499 0.909 rs28632018 chr4:120386730 T/C cg09307838 chr4:120376055 NA 0.79 11.39 0.53 1.27e-25 Corneal astigmatism; LUSC trans rs6104690 0.967 rs6040286 chr20:10985143 T/C cg07172334 chr21:31655261 KRTAP24-1 -0.34 -6.12 -0.32 2.56e-9 Bladder cancer; LUSC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg12365402 chr11:9010492 NRIP3 0.48 8.81 0.43 6.84e-17 Hemoglobin concentration; LUSC cis rs4889855 0.530 rs12946972 chr17:78618922 A/G cg16591659 chr17:78472290 NA -0.32 -5.95 -0.31 6.8e-9 Fractional excretion of uric acid; LUSC cis rs6500602 0.789 rs2404546 chr16:4479734 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.46 5.89 0.31 9.54e-9 Schizophrenia; LUSC cis rs2070433 0.800 rs11700596 chr21:47874054 G/C cg12379764 chr21:47803548 PCNT 0.79 10.34 0.49 6.57e-22 Lymphocyte counts; LUSC cis rs10100465 0.961 rs10108248 chr8:118679410 T/G cg09430518 chr8:118662568 NA 0.3 5.82 0.3 1.38e-8 Leprosy; LUSC cis rs6570726 0.934 rs9484995 chr6:145781114 T/A cg23711669 chr6:146136114 FBXO30 -0.72 -12.17 -0.55 1.81e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs9925964 0.933 rs749671 chr16:31088347 G/A cg02466173 chr16:30829666 NA 0.36 6.4 0.33 5.33e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg06552810 chr11:31128660 NA -0.4 -7.03 -0.36 1.15e-11 Red blood cell count; LUSC cis rs12368653 0.591 rs1552842 chr12:58012163 A/G cg12615879 chr12:58013172 SLC26A10 -0.41 -10.11 -0.48 3.84e-21 Multiple sclerosis; LUSC cis rs947211 0.898 rs1772153 chr1:205745782 C/T cg14893161 chr1:205819251 PM20D1 -0.46 -6.03 -0.31 4.41e-9 Parkinson's disease; LUSC cis rs17826219 0.636 rs2449770 chr17:29101064 G/T cg13385521 chr17:29058706 SUZ12P 0.69 6.79 0.35 5.27e-11 Body mass index; LUSC cis rs4853525 0.923 rs2355575 chr2:191728404 T/G cg11845111 chr2:191398756 TMEM194B -0.41 -6.0 -0.31 5.16e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg24642844 chr7:1081250 C7orf50 -0.69 -9.87 -0.48 2.55e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2235573 0.527 rs139883 chr22:38369027 C/T cg19894588 chr14:64061835 NA 0.51 7.25 0.37 2.87e-12 Glioblastoma;Glioma; LUSC cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg18681998 chr4:17616180 MED28 0.78 13.82 0.6 1.1e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11608355 0.545 rs56144717 chr12:109902304 T/C cg05360138 chr12:110035743 NA 0.91 11.65 0.54 1.48e-26 Neuroticism; LUSC cis rs10760123 1 rs10760123 chr9:123650534 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.93 0.31 7.55e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9323205 0.834 rs12434435 chr14:51667524 G/T cg23942311 chr14:51606299 NA 0.37 7.59 0.38 3.22e-13 Cancer; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg18236224 chr12:54718547 COPZ1 0.41 6.04 0.31 4.22e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1371867 0.810 rs2860518 chr8:101238120 G/T cg00191853 chr8:101177733 SPAG1 0.36 5.98 0.31 5.64e-9 Atrioventricular conduction; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12817154 chr4:864995 GAK -0.67 -6.21 -0.32 1.56e-9 Cognitive performance; LUSC cis rs7705502 0.962 rs72810995 chr5:173331851 A/G cg18693985 chr5:173351052 CPEB4 -0.38 -5.87 -0.31 1.05e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs3092073 0.617 rs3746513 chr20:44594228 G/A cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.38 -5.95 -0.31 6.94e-9 Intelligence (multi-trait analysis); LUSC cis rs6460942 0.556 rs2287067 chr7:12370533 T/C cg06484146 chr7:12443880 VWDE -0.51 -6.24 -0.32 1.32e-9 Coronary artery disease; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg00694512 chr3:126423063 CHCHD6 -0.37 -6.04 -0.31 4e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs1784581 0.651 rs1784593 chr6:162386096 A/T cg17173639 chr6:162384350 PARK2 -0.66 -11.93 -0.55 1.39e-27 Itch intensity from mosquito bite; LUSC trans rs1945213 0.694 rs67394518 chr11:55855303 G/A cg15704280 chr7:45808275 SEPT13 0.76 7.89 0.4 4.36e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs950776 0.616 rs647041 chr15:78880481 T/C cg22563815 chr15:78856949 CHRNA5 -0.25 -6.16 -0.32 2.11e-9 Sudden cardiac arrest; LUSC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg17366294 chr4:99064904 C4orf37 0.56 9.85 0.47 2.83e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg00933542 chr6:150070202 PCMT1 0.32 6.7 0.34 8.68e-11 Lung cancer; LUSC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg00343986 chr7:65444356 GUSB 0.47 7.12 0.36 6.6e-12 Calcium levels; LUSC cis rs9650315 0.530 rs68005065 chr8:57090308 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.54 8.36 0.42 1.66e-15 Height; LUSC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg05535760 chr7:792225 HEATR2 -0.77 -7.65 -0.39 2.16e-13 Cerebrospinal P-tau181p levels; LUSC cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg13010199 chr12:38710504 ALG10B 0.69 11.46 0.53 7.01e-26 Heart rate; LUSC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg04398451 chr17:18023971 MYO15A 0.37 5.87 0.31 1.07e-8 Total body bone mineral density; LUSC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2067615 0.579 rs7486905 chr12:107160169 G/A cg15890332 chr12:107067104 RFX4 0.34 6.2 0.32 1.66e-9 Heart rate; LUSC cis rs7241530 0.662 rs35857611 chr18:75901744 C/G cg14642773 chr18:75888474 NA 0.41 6.27 0.32 1.14e-9 Educational attainment (years of education); LUSC cis rs1538970 0.851 rs61788285 chr1:45919234 A/C cg05343316 chr1:45956843 TESK2 0.67 8.96 0.44 2.29e-17 Platelet count; LUSC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg08270630 chr22:50330655 NA -0.45 -6.77 -0.35 5.64e-11 Schizophrenia; LUSC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg27121462 chr16:89883253 FANCA 0.56 9.24 0.45 2.87e-18 Vitiligo; LUSC trans rs1908814 0.516 rs13281315 chr8:11794855 C/G cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.22e-15 Neuroticism; LUSC cis rs12148488 0.966 rs1867149 chr15:75339993 C/T cg09165964 chr15:75287851 SCAMP5 -0.48 -6.94 -0.36 2e-11 Caffeine consumption; LUSC cis rs10782582 0.593 rs12126155 chr1:76131555 C/G cg22875332 chr1:76189707 ACADM -0.42 -6.2 -0.32 1.64e-9 Daytime sleep phenotypes; LUSC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg14552801 chr7:65878734 NA 0.37 5.75 0.3 1.97e-8 Aortic root size; LUSC cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg06784218 chr1:46089804 CCDC17 0.48 9.18 0.45 4.71e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg11062466 chr8:58055876 NA 0.5 6.43 0.33 4.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs1018697 1.000 rs7896903 chr10:104566417 A/G cg04362960 chr10:104952993 NT5C2 0.5 6.98 0.36 1.61e-11 Colorectal adenoma (advanced); LUSC cis rs2439831 0.850 rs7183809 chr15:44120868 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.65 0.34 1.17e-10 Lung cancer in ever smokers; LUSC cis rs6674176 0.542 rs803679 chr1:44349405 G/A cg13246856 chr1:44399776 ARTN 0.28 5.78 0.3 1.68e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11997175 0.846 rs11776207 chr8:33765126 G/T ch.8.33884649F chr8:33765107 NA -0.46 -6.93 -0.35 2.22e-11 Body mass index; LUSC cis rs4930103 0.935 rs2839698 chr11:2018853 G/A cg23202291 chr11:1979235 NA 0.39 6.1 0.32 2.96e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs34172651 0.876 rs2547033 chr16:24743657 C/T cg04756594 chr16:24857601 SLC5A11 0.34 5.85 0.31 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs7809950 0.678 rs2301801 chr7:106870746 T/C cg23024343 chr7:107201750 COG5 -0.65 -9.56 -0.46 2.59e-19 Coronary artery disease; LUSC trans rs6601327 1.000 rs6601327 chr8:9395532 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -5.96 -0.31 6.57e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs968451 0.951 rs12627838 chr22:39733521 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.68 8.57 0.42 3.96e-16 Primary biliary cholangitis; LUSC cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg22709100 chr7:91322751 NA -0.39 -5.68 -0.3 2.88e-8 Breast cancer; LUSC cis rs7605827 0.930 rs763356 chr2:15518816 G/T cg19274914 chr2:15703543 NA 0.45 8.73 0.43 1.27e-16 Educational attainment (years of education); LUSC cis rs73198271 0.740 rs28402110 chr8:8647249 C/A cg01851573 chr8:8652454 MFHAS1 0.53 8.45 0.42 8.97e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs724744 0.742 rs1205936 chr6:22358116 A/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC trans rs11098499 0.863 rs11933966 chr4:120476715 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs16937 0.711 rs11240390 chr1:205179457 A/G cg21643547 chr1:205240462 TMCC2 -0.33 -5.7 -0.3 2.64e-8 Schizophrenia; LUSC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.87 -0.48 2.59e-20 Glomerular filtration rate (creatinine); LUSC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg18352616 chr4:3374830 RGS12 -0.32 -6.42 -0.33 4.57e-10 Serum sulfate level; LUSC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.64 9.41 0.46 8.09e-19 IgG glycosylation; LUSC cis rs7215564 0.908 rs9972968 chr17:78652569 T/C cg09596252 chr17:78655493 RPTOR 0.57 6.12 0.32 2.65e-9 Myopia (pathological); LUSC cis rs11168618 0.846 rs11168592 chr12:48865079 C/T cg24011408 chr12:48396354 COL2A1 0.38 5.95 0.31 6.65e-9 Adiponectin levels; LUSC cis rs7590368 0.715 rs55863332 chr2:10958976 A/G cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05608694 chr5:141303209 KIAA0141 -0.5 -6.35 -0.33 6.95e-10 Bipolar disorder and schizophrenia; LUSC cis rs453301 0.686 rs1045527 chr8:8890041 A/G cg15556689 chr8:8085844 FLJ10661 -0.62 -9.98 -0.48 1.08e-20 Joint mobility (Beighton score); LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg02018176 chr4:1364513 KIAA1530 0.51 8.83 0.43 6.12e-17 Obesity-related traits; LUSC cis rs6546550 0.935 rs2305523 chr2:70039677 G/T cg02498382 chr2:70120550 SNRNP27 0.28 6.9 0.35 2.59e-11 Prevalent atrial fibrillation; LUSC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.23e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.88 0.31 1.01e-8 Menopause (age at onset); LUSC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg11764359 chr7:65958608 NA 0.53 6.99 0.36 1.5e-11 Aortic root size; LUSC cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg10523679 chr1:76189770 ACADM 0.76 9.46 0.46 5.83e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6456156 0.586 rs12203510 chr6:167473006 C/T cg06454157 chr6:167490870 NA -0.27 -6.48 -0.33 3.25e-10 Primary biliary cholangitis; LUSC cis rs9517320 0.534 rs4772088 chr13:99138270 T/G cg20487152 chr13:99095054 FARP1 -0.45 -7.96 -0.4 2.72e-14 Longevity; LUSC cis rs17270561 0.609 rs9379785 chr6:25726213 G/A cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg04539111 chr16:67997858 SLC12A4 -0.48 -6.37 -0.33 6.35e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs1027479 0.842 rs3019347 chr8:109725416 T/C cg14904725 chr13:113777045 F10 -0.25 -5.95 -0.31 6.67e-9 Facial morphology (factor 6, height of vermillion lower lip); LUSC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg08684580 chr7:98029266 BAIAP2L1 0.43 8.02 0.4 1.82e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.89 0.44 3.86e-17 Schizophrenia; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.33 -0.41 2.17e-15 Lymphocyte counts; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02666966 chr16:28857347 TUFM 0.72 6.22 0.32 1.48e-9 Cognitive performance; LUSC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.35 -7.53 -0.38 4.67e-13 Cystic fibrosis severity; LUSC cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg00321850 chr1:175162397 KIAA0040 0.46 7.86 0.4 5.38e-14 Diastolic blood pressure; LUSC cis rs1387259 0.899 rs7307566 chr12:48604682 A/G cg04545296 chr12:48745243 ZNF641 0.33 6.17 0.32 2e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs1044826 1.000 rs2233815 chr3:139195177 C/T cg00490450 chr3:139108681 COPB2 0.52 6.78 0.35 5.37e-11 Obesity-related traits; LUSC cis rs17539620 0.808 rs6904264 chr6:154878380 C/G cg20019720 chr6:154832845 CNKSR3 -0.42 -6.17 -0.32 1.92e-9 Lipoprotein (a) levels; LUSC cis rs1322512 1.000 rs2996635 chr6:153011163 C/T cg27316956 chr6:152958899 SYNE1 0.34 5.99 0.31 5.4e-9 Tonometry; LUSC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg08677398 chr8:58056175 NA 0.54 6.56 0.34 2.1e-10 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.771 rs4419647 chr6:86225739 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 10.61 0.5 7.15e-23 Response to antipsychotic treatment; LUSC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg03609598 chr5:56110824 MAP3K1 -0.41 -5.92 -0.31 7.83e-9 Initial pursuit acceleration; LUSC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg12463550 chr7:65579703 CRCP 0.52 7.54 0.38 4.45e-13 Aortic root size; LUSC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg23758822 chr17:41437982 NA 1.03 20.73 0.75 5.79e-62 Menopause (age at onset); LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.51 0.53 4.85e-26 Menopause (age at onset); LUSC cis rs11997175 0.655 rs7833512 chr8:33662884 C/T ch.8.33884649F chr8:33765107 NA 0.39 6.11 0.32 2.73e-9 Body mass index; LUSC cis rs7582180 0.676 rs11691135 chr2:100934038 C/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.5 -0.42 6.25e-16 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.7 -10.95 -0.51 4.69e-24 Menarche (age at onset); LUSC trans rs11098499 0.542 rs10440343 chr4:120309787 G/C cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs4474465 0.541 rs11237527 chr11:78219664 C/A cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg16606324 chr3:10149918 C3orf24 0.59 8.59 0.43 3.27e-16 Alzheimer's disease; LUSC cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg17507749 chr15:85114479 UBE2QP1 -0.59 -7.68 -0.39 1.79e-13 Schizophrenia; LUSC cis rs7940866 0.874 rs10894306 chr11:130873882 A/C cg12179176 chr11:130786555 SNX19 0.63 9.82 0.47 3.7e-20 Schizophrenia; LUSC cis rs7223966 0.961 rs35844156 chr17:61837568 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.91 0.35 2.52e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9479482 1.000 rs9478354 chr6:150334366 G/A cg25797454 chr6:150327115 RAET1K 0.37 8.47 0.42 7.99e-16 Alopecia areata; LUSC cis rs7733403 1 rs7733403 chr5:140154215 A/G cg19875535 chr5:140030758 IK 0.49 7.97 0.4 2.6e-14 Schizophrenia; LUSC cis rs2580764 0.678 rs2588521 chr2:55203931 C/G cg09592903 chr2:55203963 RTN4 0.49 10.17 0.49 2.39e-21 Mean platelet volume; LUSC cis rs1577917 1.000 rs10944163 chr6:86658693 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.91 -0.35 2.45e-11 Response to antipsychotic treatment; LUSC cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg12011299 chr4:100065546 ADH4 -0.72 -11.29 -0.53 2.86e-25 Alcohol dependence; LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.99 -0.31 5.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs765787 0.530 rs1706830 chr15:45516229 G/A cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.44e-17 Uric acid levels; LUSC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg25019033 chr10:957182 NA -0.52 -6.58 -0.34 1.77e-10 Eosinophil percentage of granulocytes; LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg12564285 chr5:131593104 PDLIM4 0.54 10.11 0.48 3.78e-21 Acylcarnitine levels; LUSC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg22496380 chr5:211416 CCDC127 -0.73 -9.04 -0.44 1.31e-17 Breast cancer; LUSC cis rs10791323 0.569 rs1119851 chr11:133742842 T/C cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg00074818 chr8:8560427 CLDN23 0.56 9.62 0.47 1.69e-19 Obesity-related traits; LUSC cis rs939574 0.790 rs72955444 chr2:220094673 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 6.07 0.32 3.4e-9 Platelet distribution width; LUSC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.73 -11.17 -0.52 8.16e-25 Hip circumference adjusted for BMI; LUSC cis rs6121246 0.529 rs6060134 chr20:30176794 A/G cg13852791 chr20:30311386 BCL2L1 0.71 8.05 0.4 1.49e-14 Mean corpuscular hemoglobin; LUSC trans rs11039798 0.541 rs12283728 chr11:48796407 G/A cg15704280 chr7:45808275 SEPT13 0.78 7.46 0.38 7.71e-13 Axial length; LUSC cis rs2742417 0.603 rs2742449 chr3:45764544 T/C cg04837898 chr3:45731254 SACM1L -0.46 -7.35 -0.37 1.53e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7119 0.635 rs2682910 chr15:77880114 C/A cg27398640 chr15:77910606 LINGO1 0.35 8.39 0.42 1.35e-15 Type 2 diabetes; LUSC trans rs2243480 0.708 rs35825036 chr7:65986502 T/C cg10756647 chr7:56101905 PSPH 0.89 9.05 0.44 1.19e-17 Diabetic kidney disease; LUSC cis rs9905704 0.918 rs12942969 chr17:56892872 A/T cg12560992 chr17:57184187 TRIM37 0.55 7.84 0.39 6.19e-14 Testicular germ cell tumor; LUSC cis rs4843185 0.516 rs374029 chr16:85725953 G/A cg00168118 chr16:85669675 KIAA0182 0.38 6.11 0.32 2.84e-9 Platelet distribution width; LUSC cis rs7385804 0.727 rs551238 chr7:100321528 G/T cg20848291 chr7:100343083 ZAN 0.37 5.84 0.3 1.22e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs9837602 1.000 rs62285462 chr3:99769834 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.3 0.33 9.59e-10 Breast cancer; LUSC cis rs7759001 0.857 rs4711147 chr6:27344496 A/G cg18711553 chr6:27366782 ZNF391 0.41 5.95 0.31 6.67e-9 Glomerular filtration rate (creatinine); LUSC cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg14993813 chr1:46806288 NSUN4 -0.52 -7.17 -0.37 4.72e-12 Menopause (age at onset); LUSC cis rs2637266 1.000 rs7478008 chr10:78355575 T/A cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs708547 0.874 rs1315006 chr4:57858193 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.54 -6.81 -0.35 4.44e-11 Response to bleomycin (chromatid breaks); LUSC trans rs62103177 0.525 rs1835410 chr18:77702025 T/C cg05926928 chr17:57297772 GDPD1 -1.14 -13.46 -0.59 2.75e-33 Opioid sensitivity; LUSC trans rs7618501 0.603 rs72942333 chr3:49986118 T/C cg21659725 chr3:3221576 CRBN 0.64 10.6 0.5 7.9e-23 Intelligence (multi-trait analysis); LUSC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg07952391 chr2:88470173 THNSL2 0.77 6.84 0.35 3.74e-11 Plasma clusterin levels; LUSC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg12310025 chr6:25882481 NA -0.47 -8.08 -0.4 1.16e-14 Intelligence (multi-trait analysis); LUSC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg22903471 chr2:27725779 GCKR -0.41 -6.96 -0.36 1.83e-11 Total body bone mineral density; LUSC cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg20307385 chr11:47447363 PSMC3 -0.5 -6.36 -0.33 6.51e-10 Subjective well-being; LUSC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg18404041 chr3:52824283 ITIH1 -0.62 -12.13 -0.55 2.61e-28 Bipolar disorder; LUSC cis rs12579753 1.000 rs12821073 chr12:82183260 G/T cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.21e-8 Resting heart rate; LUSC cis rs208520 0.955 rs12202599 chr6:67001573 A/G cg07460842 chr6:66804631 NA 0.83 10.18 0.49 2.15e-21 Exhaled nitric oxide output; LUSC cis rs1371867 0.846 rs1660345 chr8:101322762 C/A cg06636551 chr8:101224915 SPAG1 -0.46 -8.29 -0.41 2.77e-15 Atrioventricular conduction; LUSC cis rs796364 0.806 rs79053279 chr2:201057443 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -7.96 -0.4 2.71e-14 Schizophrenia; LUSC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg22467129 chr15:76604101 ETFA -0.45 -7.24 -0.37 3.05e-12 Blood metabolite levels; LUSC cis rs34375054 0.573 rs12811438 chr12:125653490 C/T cg25124228 chr12:125621409 AACS -0.51 -6.47 -0.33 3.42e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6964587 1.000 rs11981461 chr7:91692662 A/G cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs9467773 0.620 rs4368798 chr6:26593471 A/G cg09904177 chr6:26538194 HMGN4 0.68 12.18 0.55 1.72e-28 Intelligence (multi-trait analysis); LUSC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg07636037 chr3:49044803 WDR6 0.67 8.73 0.43 1.25e-16 Menarche (age at onset); LUSC trans rs6089829 0.925 rs6122087 chr20:61664553 T/C cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs2295359 0.892 rs56920441 chr1:67652012 A/G cg03340356 chr1:67600835 NA 0.42 6.63 0.34 1.37e-10 Psoriasis; LUSC trans rs877282 0.583 rs11253424 chr10:813426 C/T cg22713356 chr15:30763199 NA 0.66 9.26 0.45 2.52e-18 Uric acid levels; LUSC cis rs4654899 0.802 rs10916903 chr1:21247944 T/C cg02927042 chr1:21476669 EIF4G3 -0.37 -5.71 -0.3 2.48e-8 Superior frontal gyrus grey matter volume; LUSC cis rs701145 0.878 rs433903 chr3:153980130 A/G cg17054900 chr3:154042577 DHX36 0.82 8.49 0.42 7.02e-16 Coronary artery disease; LUSC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg06636001 chr8:8085503 FLJ10661 0.67 11.06 0.52 1.97e-24 Mood instability; LUSC cis rs2279817 1.000 rs2279816 chr1:18021867 T/C cg21791023 chr1:18019539 ARHGEF10L 0.47 6.54 0.34 2.32e-10 Neuroticism; LUSC cis rs9309473 0.606 rs62149777 chr2:73795364 G/A cg20560298 chr2:73613845 ALMS1 -0.55 -6.56 -0.34 2.02e-10 Metabolite levels; LUSC cis rs34779708 0.931 rs4934731 chr10:35431636 T/C cg03585969 chr10:35415529 CREM 0.59 8.83 0.43 6.14e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs60733400 0.500 rs72644697 chr1:2533605 G/A cg18932078 chr1:2524107 MMEL1 0.33 7.31 0.37 2.03e-12 Multiple sclerosis; LUSC trans rs7824557 0.767 rs1897951 chr8:11169854 C/T cg08975724 chr8:8085496 FLJ10661 0.46 6.74 0.35 6.94e-11 Retinal vascular caliber; LUSC cis rs870825 0.860 rs72703525 chr4:185605154 T/C cg04058563 chr4:185651563 MLF1IP 0.77 10.26 0.49 1.17e-21 Blood protein levels; LUSC cis rs3768617 0.510 rs20563 chr1:183085755 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.71 -10.89 -0.51 7.73e-24 Fuchs's corneal dystrophy; LUSC cis rs1979679 0.608 rs6487691 chr12:28724216 T/C cg13890972 chr12:28721907 NA -0.42 -6.01 -0.31 4.75e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs56283067 0.887 rs9472365 chr6:44770214 C/G cg18551225 chr6:44695536 NA 0.43 6.92 0.35 2.27e-11 Total body bone mineral density; LUSC cis rs929354 0.772 rs1002389 chr7:156968323 C/G cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg03676636 chr4:99064102 C4orf37 0.37 7.8 0.39 8.22e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.14 -0.72 1.16e-55 Height; LUSC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg17971929 chr21:40555470 PSMG1 -0.65 -10.63 -0.5 6.09e-23 Cognitive function; LUSC cis rs13315871 1.000 rs71311855 chr3:58320507 A/G cg20936604 chr3:58311152 NA -0.76 -7.26 -0.37 2.66e-12 Cholesterol, total; LUSC cis rs354225 0.626 rs6740893 chr2:54834380 G/A cg01766943 chr2:54829624 SPTBN1 0.44 6.83 0.35 4.13e-11 Schizophrenia; LUSC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg18876405 chr7:65276391 NA -0.58 -9.38 -0.46 1.08e-18 Aortic root size; LUSC cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs6547741 1.000 rs6547741 chr2:27855924 G/A cg27432699 chr2:27873401 GPN1 0.78 14.13 0.61 7.32e-36 Oral cavity cancer; LUSC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg23283495 chr1:209979779 IRF6 0.65 9.35 0.46 1.28e-18 Cleft lip with or without cleft palate; LUSC cis rs2354432 0.660 rs10751415 chr1:146830785 T/A cg25205988 chr1:146714368 CHD1L 0.91 8.77 0.43 9.47e-17 Mitochondrial DNA levels; LUSC cis rs2439831 0.867 rs7170489 chr15:43636651 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs308403 0.568 rs1512975 chr4:123657342 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.78 10.09 0.48 4.57e-21 Blood protein levels; LUSC cis rs9611565 0.607 rs132792 chr22:42062822 C/T cg03806693 chr22:41940476 POLR3H 0.85 12.45 0.56 1.78e-29 Vitiligo; LUSC cis rs2710642 0.815 rs6545971 chr2:63074986 A/T cg17519650 chr2:63277830 OTX1 0.52 7.36 0.37 1.41e-12 LDL cholesterol levels;LDL cholesterol; LUSC cis rs1949733 0.958 rs2631731 chr4:8429817 A/G cg13073564 chr4:8508604 NA -0.47 -8.82 -0.43 6.42e-17 Response to antineoplastic agents; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18088653 chr15:71407757 CT62 -0.4 -6.44 -0.33 4.23e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg19230755 chr7:65878503 NA 0.43 6.06 0.31 3.67e-9 Aortic root size; LUSC trans rs4714291 0.832 rs1524087 chr6:40057504 A/G cg02267698 chr19:7991119 CTXN1 -0.56 -8.45 -0.42 9.07e-16 Strep throat; LUSC cis rs9549260 0.709 rs4943795 chr13:41173433 C/T cg21288729 chr13:41239152 FOXO1 -0.58 -8.05 -0.4 1.51e-14 Red blood cell count; LUSC cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg01065977 chr19:18549689 ISYNA1 -0.22 -5.78 -0.3 1.73e-8 Breast cancer; LUSC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg12310025 chr6:25882481 NA -0.52 -9.44 -0.46 6.81e-19 Blood metabolite levels; LUSC cis rs710216 0.752 rs1770810 chr1:43406113 G/A cg22176566 chr1:43424700 SLC2A1 0.5 6.08 0.32 3.2e-9 Red cell distribution width; LUSC cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg13319975 chr6:146136371 FBXO30 -0.53 -8.04 -0.4 1.62e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs4332037 0.539 rs11762636 chr7:2061111 C/A cg11693508 chr17:37793320 STARD3 0.56 6.7 0.34 8.71e-11 Bipolar disorder; LUSC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg09904177 chr6:26538194 HMGN4 0.5 6.19 0.32 1.78e-9 Intelligence (multi-trait analysis); LUSC cis rs9309473 0.500 rs1528169 chr2:73669186 T/C cg20560298 chr2:73613845 ALMS1 0.47 7.38 0.37 1.25e-12 Metabolite levels; LUSC cis rs6087771 0.781 rs6089067 chr20:30358894 G/C cg13852791 chr20:30311386 BCL2L1 0.94 14.4 0.62 6.36e-37 Subcortical brain region volumes;Putamen volume; LUSC cis rs2857891 0.695 rs2857895 chr11:6982992 C/G cg14883916 chr11:6947541 ZNF215 -0.41 -5.78 -0.3 1.75e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.42 -0.42 1.13e-15 Lymphocyte counts; LUSC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg15147215 chr3:52552868 STAB1 -0.3 -5.95 -0.31 6.85e-9 Bipolar disorder; LUSC cis rs13191362 0.573 rs9365499 chr6:163271833 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.32 5.79 0.3 1.6e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg11266682 chr4:10021025 SLC2A9 -0.46 -8.11 -0.41 9.63e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg04455712 chr21:45112962 RRP1B -0.48 -9.29 -0.45 2e-18 Mean corpuscular volume; LUSC cis rs11630290 0.667 rs6494441 chr15:64166877 A/G cg12036633 chr15:63758958 NA 0.5 6.06 0.31 3.73e-9 Iris characteristics; LUSC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.47 0.38 7.02e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6582630 0.576 rs4403871 chr12:38292193 G/A cg26384229 chr12:38710491 ALG10B -0.58 -8.56 -0.42 4.22e-16 Drug-induced liver injury (flucloxacillin); LUSC trans rs6951245 1.000 rs77760339 chr7:1083927 G/T cg13565492 chr6:43139072 SRF -0.57 -6.05 -0.31 3.93e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs5753618 0.561 rs2413047 chr22:31666026 A/G cg22777020 chr22:31556080 RNF185 -0.46 -5.8 -0.3 1.55e-8 Colorectal cancer; LUSC cis rs76935404 0.811 rs8100418 chr19:41414363 A/T cg04176888 chr19:41596066 CYP2A13 0.39 6.06 0.31 3.69e-9 nicotine metabolite ratio in current smokers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18091465 chr15:82551086 EFTUD1 0.49 6.15 0.32 2.26e-9 Bipolar disorder and schizophrenia; LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 7.9e-43 Menopause (age at onset); LUSC cis rs6940638 0.715 rs9348751 chr6:27067190 T/A cg05738196 chr6:26577821 NA -0.48 -6.81 -0.35 4.52e-11 Intelligence (multi-trait analysis); LUSC cis rs8180040 0.966 rs13072802 chr3:47346415 G/C cg02527881 chr3:46936655 PTH1R -0.42 -7.49 -0.38 6.18e-13 Colorectal cancer; LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg20283391 chr11:68216788 NA -0.59 -8.31 -0.41 2.46e-15 Total body bone mineral density; LUSC cis rs1595825 0.891 rs75373125 chr2:198657044 G/A cg00982548 chr2:198649783 BOLL -0.56 -6.58 -0.34 1.78e-10 Ulcerative colitis; LUSC cis rs3774830 0.714 rs7685158 chr4:5462776 C/T cg26943120 chr4:5472116 STK32B 0.3 5.67 0.3 3.12e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2933343 0.951 rs9871612 chr3:128570402 C/T cg11901034 chr3:128598214 ACAD9 -0.4 -5.66 -0.3 3.22e-8 IgG glycosylation; LUSC cis rs887829 0.569 rs3806597 chr2:234637569 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.43 7.23 0.37 3.32e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg26380479 chr7:97908229 NA -0.26 -5.8 -0.3 1.54e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC trans rs758324 0.947 rs559971 chr5:131316164 A/G cg21450652 chr3:46875436 PRSS42 -0.43 -6.09 -0.32 3.14e-9 Alzheimer's disease in APOE e4- carriers; LUSC cis rs6815814 0.950 rs56408159 chr4:38812116 T/A cg02016764 chr4:38805732 TLR1 -0.54 -5.74 -0.3 2.17e-8 Breast cancer; LUSC trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg13615516 chr5:77269221 NA 0.39 6.69 0.34 9.25e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg13852791 chr20:30311386 BCL2L1 0.82 10.81 0.51 1.42e-23 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg21724239 chr8:58056113 NA 0.61 7.21 0.37 3.7e-12 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs1937131 chr6:25744831 A/T cg16482183 chr6:26056742 HIST1H1C -0.59 -8.47 -0.42 7.86e-16 Iron status biomarkers; LUSC cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.5 0.5 1.79e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07469949 chr19:17378240 C19orf62 0.74 6.46 0.33 3.79e-10 Cognitive performance; LUSC cis rs62400317 0.859 rs12209161 chr6:45104321 G/A cg18551225 chr6:44695536 NA -0.42 -6.89 -0.35 2.73e-11 Total body bone mineral density; LUSC cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg10523679 chr1:76189770 ACADM -0.5 -7.26 -0.37 2.68e-12 Daytime sleep phenotypes; LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg27535305 chr1:53392650 SCP2 -0.37 -6.91 -0.35 2.46e-11 Monocyte count; LUSC cis rs10464366 0.746 rs4723822 chr7:39141613 C/T cg21665744 chr7:39171113 POU6F2 0.44 6.78 0.35 5.34e-11 IgG glycosylation; LUSC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg23093090 chr10:104574429 C10orf26 0.45 8.55 0.42 4.38e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4566357 0.595 rs2272203 chr2:227914655 C/G cg11843606 chr2:227700838 RHBDD1 -0.53 -8.21 -0.41 4.93e-15 Coronary artery disease; LUSC cis rs4363385 0.510 rs17627288 chr1:152923848 C/T cg00922841 chr1:152955080 SPRR1A -0.36 -5.96 -0.31 6.58e-9 Inflammatory skin disease; LUSC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg16228356 chr17:43848958 NA -0.27 -6.28 -0.33 1.03e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9457247 0.555 rs2247325 chr6:167369992 A/G cg23791538 chr6:167370224 RNASET2 0.52 8.64 0.43 2.31e-16 Crohn's disease; LUSC cis rs992157 0.798 rs2382818 chr2:219155907 A/T cg00012203 chr2:219082015 ARPC2 -0.68 -11.04 -0.52 2.26e-24 Colorectal cancer; LUSC cis rs965604 0.965 rs36146269 chr15:78779510 T/A cg18825076 chr15:78729989 IREB2 -0.43 -6.82 -0.35 4.31e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs877282 0.842 rs7092986 chr10:756373 G/A cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs722599 0.748 rs59112602 chr14:75358817 C/G cg08847533 chr14:75593920 NEK9 -0.48 -6.84 -0.35 3.72e-11 IgG glycosylation; LUSC cis rs1113500 0.787 rs11185266 chr1:108642664 G/A cg06207961 chr1:108661230 NA 0.31 5.71 0.3 2.47e-8 Growth-regulated protein alpha levels; LUSC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.51 7.85 0.39 5.55e-14 Eosinophil percentage of white cells; LUSC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg26335602 chr6:28129616 ZNF389 0.44 5.88 0.31 9.91e-9 Parkinson's disease; LUSC cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg05347473 chr6:146136440 FBXO30 0.48 7.9 0.4 4.04e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.52 0.34 2.54e-10 Schizophrenia; LUSC cis rs308403 0.568 rs13138426 chr4:123652580 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.78 10.11 0.48 3.96e-21 Blood protein levels; LUSC cis rs3781663 0.553 rs875108 chr11:70004695 G/A cg24276624 chr11:69982941 ANO1 -0.44 -6.77 -0.35 5.87e-11 Survival in rectal cancer; LUSC cis rs7589342 0.929 rs7562054 chr2:106433513 G/C cg14210321 chr2:106509881 NCK2 -0.54 -8.12 -0.41 9.28e-15 Addiction; LUSC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg08847533 chr14:75593920 NEK9 -0.85 -15.34 -0.64 1.46e-40 Height; LUSC cis rs4474465 1.000 rs7121283 chr11:78149340 T/A cg27205649 chr11:78285834 NARS2 -0.5 -5.86 -0.31 1.08e-8 Alzheimer's disease (survival time); LUSC cis rs6964587 0.967 rs12671991 chr7:91559481 T/C cg17063962 chr7:91808500 NA -0.57 -8.75 -0.43 1.07e-16 Breast cancer; LUSC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -6.07 -0.32 3.4e-9 Alzheimer's disease (late onset); LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.42 -5.76 -0.3 1.92e-8 Gut microbiome composition (summer); LUSC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg13902645 chr11:5959945 NA -0.56 -8.63 -0.43 2.47e-16 DNA methylation (variation); LUSC cis rs1801251 0.778 rs809639 chr2:233731244 C/G cg08000102 chr2:233561755 GIGYF2 0.52 8.15 0.41 7.49e-15 Coronary artery disease; LUSC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg10802521 chr3:52805072 NEK4 -0.52 -8.63 -0.43 2.5e-16 Electroencephalogram traits; LUSC cis rs7172677 0.960 rs8026273 chr15:75413766 T/A cg14664628 chr15:75095509 CSK -0.47 -5.98 -0.31 5.64e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs10740039 0.883 rs2119911 chr10:62399566 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs963731 0.649 rs4142729 chr2:39222915 A/G cg04010122 chr2:39346883 SOS1 -0.75 -5.8 -0.3 1.51e-8 Corticobasal degeneration; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg03909863 chr11:638404 DRD4 -0.41 -6.19 -0.32 1.81e-9 Systemic lupus erythematosus; LUSC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg15595755 chr5:1867978 NA 0.47 8.6 0.43 3.09e-16 Cardiovascular disease risk factors; LUSC cis rs2734839 0.929 rs2734835 chr11:113291343 T/G cg14159747 chr11:113255604 NA 0.24 6.06 0.31 3.59e-9 Information processing speed; LUSC cis rs16866061 1.000 rs72974219 chr2:225423784 G/C cg12698349 chr2:225449008 CUL3 0.87 14.02 0.61 1.97e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg17063962 chr7:91808500 NA 0.59 9.38 0.46 1.07e-18 Breast cancer; LUSC cis rs9300255 0.602 rs1727296 chr12:123647725 G/C cg00376283 chr12:123451042 ABCB9 0.67 8.44 0.42 9.73e-16 Neutrophil percentage of white cells; LUSC cis rs155076 0.938 rs261375 chr13:21871882 A/G cg14456004 chr13:21872349 NA 1.16 15.6 0.65 1.34e-41 White matter hyperintensity burden; LUSC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.06 -0.48 5.63e-21 Menarche (age at onset); LUSC cis rs12950390 0.853 rs56137679 chr17:45862112 C/G cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.45e-10 IgG glycosylation; LUSC cis rs7572644 0.640 rs34181670 chr2:28019856 T/C cg27432699 chr2:27873401 GPN1 0.55 7.26 0.37 2.74e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs12310956 0.532 rs11052948 chr12:33981973 T/C cg26384229 chr12:38710491 ALG10B 0.75 11.76 0.54 5.82e-27 Morning vs. evening chronotype; LUSC cis rs870825 0.932 rs10034861 chr4:185577450 C/T cg04058563 chr4:185651563 MLF1IP 0.85 11.46 0.53 7.47e-26 Blood protein levels; LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs17253792 0.822 rs78432811 chr14:56051545 T/C cg01858014 chr14:56050164 KTN1 -0.83 -6.3 -0.33 9.21e-10 Putamen volume; LUSC cis rs9517313 0.897 rs4772087 chr13:99115041 A/G cg07423050 chr13:99094983 FARP1 0.59 12.03 0.55 6.33e-28 Neuroticism; LUSC cis rs354225 0.544 rs13391522 chr2:54805854 T/C cg01766943 chr2:54829624 SPTBN1 0.48 7.65 0.39 2.14e-13 Schizophrenia; LUSC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 6.15 0.32 2.24e-9 Bipolar disorder; LUSC cis rs9549260 0.564 rs9549279 chr13:41315582 C/G cg21288729 chr13:41239152 FOXO1 -0.5 -7.51 -0.38 5.32e-13 Red blood cell count; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg13560548 chr3:10150139 C3orf24 0.55 7.4 0.38 1.08e-12 Alzheimer's disease; LUSC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg11764359 chr7:65958608 NA -0.52 -6.81 -0.35 4.44e-11 Aortic root size; LUSC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg26380479 chr7:97908229 NA -0.26 -5.84 -0.3 1.23e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg21141812 chr3:48556323 PFKFB4 0.35 5.9 0.31 9.14e-9 Menarche (age at onset); LUSC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg06108461 chr20:60628389 TAF4 -1.01 -16.53 -0.67 2.89e-45 Body mass index; LUSC trans rs1994135 0.630 rs11052760 chr12:33724949 A/T cg26384229 chr12:38710491 ALG10B 0.71 9.99 0.48 1.01e-20 Resting heart rate; LUSC cis rs7927592 0.956 rs7116899 chr11:68385535 G/T cg01657329 chr11:68192670 LRP5 -0.44 -6.62 -0.34 1.41e-10 Total body bone mineral density; LUSC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg26597838 chr10:835615 NA 0.79 9.84 0.47 3.08e-20 Eosinophil percentage of granulocytes; LUSC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg24675056 chr1:15929824 NA 0.46 8.02 0.4 1.83e-14 Systolic blood pressure; LUSC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg03388025 chr16:89894329 SPIRE2 0.34 7.03 0.36 1.18e-11 Vitiligo; LUSC cis rs7465272 0.515 rs34087536 chr8:143720876 G/A cg24634471 chr8:143751801 JRK 0.48 6.51 0.34 2.8e-10 Bipolar disorder and schizophrenia; LUSC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg26513180 chr16:89883248 FANCA 0.78 6.39 0.33 5.68e-10 Skin colour saturation; LUSC trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg27661571 chr11:113659931 NA -0.62 -7.42 -0.38 1.01e-12 Hip circumference adjusted for BMI; LUSC cis rs4363385 0.510 rs61815707 chr1:152909018 T/C cg25856811 chr1:152973957 SPRR3 -0.38 -6.17 -0.32 1.93e-9 Inflammatory skin disease; LUSC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg04287289 chr16:89883240 FANCA -0.43 -6.19 -0.32 1.79e-9 Vitiligo; LUSC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg08859206 chr1:53392774 SCP2 -0.44 -7.41 -0.38 1.02e-12 Monocyte count; LUSC cis rs4423214 1.000 rs12785878 chr11:71167449 G/T cg05163923 chr11:71159392 DHCR7 0.74 10.95 0.51 4.71e-24 Vitamin D levels; LUSC cis rs2439831 0.850 rs11856795 chr15:44160582 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.52 0.42 5.66e-16 Lung cancer in ever smokers; LUSC cis rs72949976 0.584 rs12471471 chr2:214023052 C/T cg08319019 chr2:214017104 IKZF2 -0.68 -11.75 -0.54 6.67e-27 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs6987853 0.661 rs4641053 chr8:42352161 G/A cg09913449 chr8:42400586 C8orf40 -0.45 -7.58 -0.38 3.49e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs9527 0.545 rs35756290 chr10:104585572 G/A cg23093090 chr10:104574429 C10orf26 -0.37 -6.08 -0.32 3.29e-9 Arsenic metabolism; LUSC trans rs3733585 0.605 rs4235355 chr4:10123078 C/A cg26043149 chr18:55253948 FECH -0.53 -7.7 -0.39 1.6e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg08949735 chr16:89699720 DPEP1 -0.23 -6.02 -0.31 4.51e-9 Vitiligo; LUSC trans rs9944715 0.954 rs7234695 chr18:43762182 T/A cg01718231 chr17:29326311 RNF135 0.52 7.41 0.38 1.04e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg13393036 chr8:95962371 TP53INP1 -0.47 -9.57 -0.46 2.48e-19 Type 2 diabetes; LUSC cis rs637571 0.528 rs566266 chr11:65573587 A/C cg17985854 chr11:65770987 BANF1;EIF1AD -0.39 -6.91 -0.35 2.42e-11 Eosinophil percentage of white cells; LUSC cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.33 0.64 1.53e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs754466 0.605 rs10824578 chr10:79578244 G/C cg17075019 chr10:79541650 NA -0.8 -12.84 -0.57 5.95e-31 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg26061582 chr7:22766209 IL6 0.43 6.33 0.33 7.85e-10 Lung cancer; LUSC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC cis rs8060686 0.668 rs12448991 chr16:68218894 T/A cg27539214 chr16:67997921 SLC12A4 -0.53 -6.88 -0.35 3.01e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg26384229 chr12:38710491 ALG10B 0.84 14.42 0.62 5.48e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs11122272 0.705 rs2486731 chr1:231532511 C/T cg06096015 chr1:231504339 EGLN1 -0.51 -9.22 -0.45 3.42e-18 Hemoglobin concentration; LUSC cis rs9616064 0.557 rs5767318 chr22:47048792 A/G cg25730555 chr22:47059586 GRAMD4 0.45 7.08 0.36 8.77e-12 Urate levels in obese individuals; LUSC trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg03146154 chr1:46216737 IPP 0.5 7.49 0.38 6.02e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2979489 0.773 rs10954993 chr8:30303388 C/T cg26383811 chr8:30366931 RBPMS 0.48 7.35 0.37 1.55e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC trans rs62103177 0.525 rs62101233 chr18:77724288 C/T cg05926928 chr17:57297772 GDPD1 1.0 11.33 0.53 2.11e-25 Opioid sensitivity; LUSC cis rs4805272 0.512 rs17772319 chr19:29343064 T/A cg12756686 chr19:29218302 NA 0.57 6.35 0.33 7.04e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6580649 0.941 rs7957764 chr12:48429701 C/T cg24011408 chr12:48396354 COL2A1 -0.51 -6.79 -0.35 5.07e-11 Lung cancer; LUSC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC cis rs2692947 0.832 rs2438972 chr2:96690873 T/C cg22654517 chr2:96458247 NA 0.33 6.61 0.34 1.48e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg16558253 chr16:72132732 DHX38 -0.4 -6.08 -0.32 3.3e-9 Fibrinogen levels; LUSC trans rs12310956 0.510 rs4931758 chr12:33871870 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.58 0.34 1.87e-10 Morning vs. evening chronotype; LUSC cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg18681998 chr4:17616180 MED28 0.77 13.41 0.59 4.22e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7824557 0.564 rs7828263 chr8:11231886 A/G cg08975724 chr8:8085496 FLJ10661 -0.49 -7.13 -0.36 6.31e-12 Retinal vascular caliber; LUSC cis rs6815814 0.950 rs56357984 chr4:38806462 G/A cg02016764 chr4:38805732 TLR1 -0.56 -5.72 -0.3 2.31e-8 Breast cancer; LUSC cis rs2235544 0.565 rs677481 chr1:54468837 A/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs9527 0.590 rs12415199 chr10:104895536 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC trans rs17076896 1.000 rs115410128 chr13:19757170 C/T cg01891818 chr17:73008509 ICT1 0.5 6.17 0.32 1.97e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg21918786 chr6:109611834 NA -0.41 -7.07 -0.36 8.95e-12 Reticulocyte fraction of red cells; LUSC cis rs11098499 0.865 rs28634456 chr4:120375778 A/G cg24375607 chr4:120327624 NA 0.77 10.99 0.52 3.44e-24 Corneal astigmatism; LUSC trans rs12579753 1.000 rs11115030 chr12:82203021 A/T cg07923666 chr12:49932857 KCNH3 -0.52 -6.51 -0.34 2.74e-10 Resting heart rate; LUSC cis rs12760731 0.623 rs12691482 chr1:178421901 T/G cg00404053 chr1:178313656 RASAL2 0.48 5.79 0.3 1.62e-8 Obesity-related traits; LUSC cis rs17270561 0.609 rs9379789 chr6:25745579 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 7.79 0.39 8.71e-14 Iron status biomarkers; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -8.69 -0.43 1.7e-16 Lymphocyte counts; LUSC cis rs11585357 0.947 rs72646795 chr1:17612120 C/T cg08277548 chr1:17600880 PADI3 -0.63 -6.54 -0.34 2.29e-10 Hair shape; LUSC cis rs9811920 0.809 rs793437 chr3:99559854 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -7.22 -0.37 3.64e-12 Axial length; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg13695877 chr6:163835251 QKI 0.46 6.14 0.32 2.33e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg23711669 chr6:146136114 FBXO30 0.82 14.37 0.62 8.27e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg02475777 chr4:1388615 CRIPAK 0.39 5.97 0.31 6.06e-9 Obesity-related traits; LUSC cis rs4363385 0.667 rs2066004 chr1:152922896 A/G cg07796016 chr1:152779584 LCE1C -0.46 -6.64 -0.34 1.26e-10 Inflammatory skin disease; LUSC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg03128945 chr5:622914 CEP72 -0.39 -6.09 -0.32 3.13e-9 Obesity-related traits; LUSC cis rs11190604 0.943 rs3750631 chr10:102279294 A/G cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2860975 1.000 rs7070074 chr10:96786886 T/C cg09036531 chr10:96991505 NA -0.41 -5.75 -0.3 2.06e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.89 -0.35 2.73e-11 Lung cancer; LUSC cis rs12950390 0.853 rs11079790 chr17:45853626 G/A cg06532163 chr17:45867833 NA 0.34 6.34 0.33 7.6e-10 IgG glycosylation; LUSC cis rs8031584 0.918 rs3817498 chr15:31268781 T/C cg14829155 chr15:31115871 NA -0.56 -7.61 -0.38 2.74e-13 Huntington's disease progression; LUSC cis rs17401966 0.540 rs4846219 chr1:10463888 C/A cg17425144 chr1:10567563 PEX14 -0.33 -5.75 -0.3 2.06e-8 Hepatocellular carcinoma; LUSC cis rs2346177 1.000 rs11125074 chr2:46655260 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.56 -8.83 -0.44 6.04e-17 HDL cholesterol; LUSC cis rs735539 0.645 rs1052209 chr13:21216850 C/T cg04906043 chr13:21280425 IL17D -0.43 -6.92 -0.35 2.38e-11 Dental caries; LUSC cis rs17540621 1.000 rs79562419 chr2:47232633 C/T cg23978866 chr2:47230407 TTC7A -0.97 -6.63 -0.34 1.38e-10 Response to statin therapy; LUSC cis rs5769765 0.908 rs4058453 chr22:50250297 T/C cg02269571 chr22:50332266 NA 0.59 7.55 0.38 4.13e-13 Schizophrenia; LUSC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg27532560 chr4:187881888 NA 0.44 6.99 0.36 1.51e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs35146811 0.660 rs3779045 chr7:99779259 T/C cg19116668 chr7:99932089 PMS2L1 -0.33 -5.66 -0.3 3.25e-8 Coronary artery disease; LUSC cis rs12950390 0.820 rs58391889 chr17:45865959 A/G cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.49e-10 IgG glycosylation; LUSC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.33 0.59 8.66e-33 Monocyte percentage of white cells; LUSC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg20406979 chr6:167373233 NA -0.26 -6.29 -0.33 9.8e-10 Crohn's disease; LUSC cis rs4363385 0.747 rs4845334 chr1:152982998 T/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.35e-13 Inflammatory skin disease; LUSC cis rs11055008 0.620 rs2111941 chr12:12829404 A/T cg09462578 chr12:12878428 APOLD1 0.43 6.28 0.33 1.05e-9 Pulse pressure; LUSC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg13877915 chr19:58951672 ZNF132 0.49 7.82 0.39 6.99e-14 Uric acid clearance; LUSC cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.82 -0.47 3.69e-20 Chronic sinus infection; LUSC cis rs9473147 0.543 rs9349407 chr6:47453378 C/G cg20196966 chr6:47445060 CD2AP 0.45 6.28 0.33 1.03e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.24 0.32 1.36e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg24513937 chr3:184016857 PSMD2 0.4 6.04 0.31 4.12e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg15445000 chr17:37608096 MED1 -0.39 -6.73 -0.35 7.38e-11 Glomerular filtration rate (creatinine); LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg10862848 chr6:42927986 GNMT -0.29 -6.81 -0.35 4.44e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6087990 1.000 rs6087990 chr20:31349908 T/C cg13636640 chr20:31349939 DNMT3B 1.05 24.5 0.8 1.36e-76 Ulcerative colitis; LUSC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg03929089 chr4:120376271 NA -1.04 -20.21 -0.74 7.12e-60 Height; LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg23758822 chr17:41437982 NA 1.04 19.44 0.73 7.67e-57 Menopause (age at onset); LUSC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg12963246 chr6:28129442 ZNF389 0.49 6.74 0.35 6.8e-11 Depression; LUSC cis rs2599510 0.755 rs67257914 chr2:32804018 G/A cg02381751 chr2:32503542 YIPF4 0.4 5.7 0.3 2.64e-8 Interleukin-18 levels; LUSC cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg12011299 chr4:100065546 ADH4 0.61 9.71 0.47 8.65e-20 Alcohol dependence; LUSC cis rs1020064 0.945 rs1030878 chr2:105910598 T/G cg02079111 chr2:105885981 TGFBRAP1 0.65 8.82 0.43 6.52e-17 AIDS; LUSC cis rs1580019 0.961 rs11765387 chr7:32494790 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.77 11.6 0.54 2.25e-26 Cognitive ability; LUSC cis rs12579753 0.869 rs12366920 chr12:82223015 G/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.03 -0.31 4.24e-9 Resting heart rate; LUSC cis rs7216064 1.000 rs9897982 chr17:65879592 G/T cg12091567 chr17:66097778 LOC651250 -0.72 -9.53 -0.46 3.34e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.51 -6.86 -0.35 3.36e-11 Multiple sclerosis; LUSC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg18252515 chr7:66147081 NA -1.25 -14.0 -0.61 2.4e-35 Diabetic kidney disease; LUSC cis rs6933660 0.512 rs13202634 chr6:151800630 C/T cg03627880 chr6:151815985 C6orf97 -0.55 -5.93 -0.31 7.46e-9 Menarche (age at onset); LUSC cis rs9527 0.590 rs10883839 chr10:104920341 A/G cg04362960 chr10:104952993 NT5C2 0.58 7.8 0.39 8.17e-14 Arsenic metabolism; LUSC cis rs950776 0.714 rs660652 chr15:78887832 A/G cg06917634 chr15:78832804 PSMA4 -0.69 -11.2 -0.52 6.3e-25 Sudden cardiac arrest; LUSC cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg22467129 chr15:76604101 ETFA -0.45 -6.99 -0.36 1.47e-11 Blood metabolite levels; LUSC trans rs1493916 0.905 rs1586988 chr18:31396001 G/C cg27147174 chr7:100797783 AP1S1 -0.65 -10.5 -0.5 1.74e-22 Life satisfaction; LUSC cis rs9287719 0.904 rs55738250 chr2:10757132 G/A cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg15704280 chr7:45808275 SEPT13 -0.84 -14.09 -0.61 1.07e-35 Height; LUSC cis rs6138458 1.000 rs227627 chr20:24912107 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.26 0.71 3.78e-52 Blood protein levels; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg00166722 chr3:10149974 C3orf24 0.54 7.45 0.38 7.83e-13 Alzheimer's disease; LUSC cis rs9815354 0.761 rs12186109 chr3:41836920 T/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.81 0.3 1.44e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7177699 0.525 rs7402376 chr15:79113570 A/G cg15571903 chr15:79123663 NA -0.33 -6.13 -0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7953508 0.506 rs3782415 chr12:93967755 T/C cg18151635 chr12:93972918 NA -0.62 -8.96 -0.44 2.35e-17 Pubertal anthropometrics; LUSC cis rs6964587 0.773 rs13236026 chr7:91885873 A/G cg17063962 chr7:91808500 NA 0.51 7.32 0.37 1.85e-12 Breast cancer; LUSC cis rs17270561 0.636 rs6923367 chr6:25745852 A/T cg16482183 chr6:26056742 HIST1H1C 0.65 9.05 0.44 1.21e-17 Iron status biomarkers; LUSC cis rs3733418 0.929 rs13149738 chr4:165905697 T/C cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -5.92 -0.31 7.89e-9 Obesity-related traits; LUSC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg20578329 chr17:80767326 TBCD -0.61 -8.33 -0.41 2.08e-15 Bone mineral accretion in asthma (oral corticosteroid dose interaction); LUSC cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.07 0.55 4.28e-28 Colorectal cancer; LUSC cis rs13385 0.769 rs10045510 chr5:139613188 T/C cg26211634 chr5:139558579 C5orf32 0.46 7.05 0.36 1.04e-11 Atrial fibrillation; LUSC trans rs12188164 0.930 rs72717436 chr5:448291 C/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg00343986 chr7:65444356 GUSB 0.47 7.04 0.36 1.12e-11 Aortic root size; LUSC cis rs8060686 0.545 rs8057119 chr16:68268836 C/T cg27539214 chr16:67997921 SLC12A4 -0.53 -6.62 -0.34 1.42e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1355223 0.545 rs12278318 chr11:34876507 C/G cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.69 -0.34 9.51e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg18876405 chr7:65276391 NA 0.67 11.74 0.54 7.23e-27 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24413235 chr2:27851648 CCDC121;GPN1 0.45 6.79 0.35 5.06e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg08219700 chr8:58056026 NA 0.65 7.64 0.39 2.29e-13 Developmental language disorder (linguistic errors); LUSC trans rs561341 1.000 rs535151 chr17:30317405 C/T cg27661571 chr11:113659931 NA -0.55 -6.73 -0.35 7.54e-11 Hip circumference adjusted for BMI; LUSC trans rs9784649 0.760 rs17343923 chr5:25052414 G/A cg08600765 chr20:34638493 LOC647979 -0.61 -7.57 -0.38 3.69e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg12365402 chr11:9010492 NRIP3 0.45 8.39 0.42 1.38e-15 Hemoglobin concentration; LUSC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg18252515 chr7:66147081 NA -0.39 -5.66 -0.3 3.22e-8 Aortic root size; LUSC cis rs790123 1.000 rs790117 chr3:122380888 C/T cg00926285 chr3:122398533 PARP14 -0.38 -5.93 -0.31 7.62e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs367943 0.901 rs171180 chr5:112817093 A/C cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs2841233 0.692 rs2028416 chr14:105348552 C/T cg03469805 chr14:105330648 KIAA0284 -0.32 -7.32 -0.37 1.89e-12 IgG glycosylation; LUSC cis rs9768139 0.683 rs4909178 chr7:158117752 T/A cg24154853 chr7:158122151 PTPRN2 0.43 8.3 0.41 2.62e-15 Calcium levels; LUSC cis rs17621444 0.522 rs4373837 chr10:121809352 A/T cg02041677 chr10:121771263 NA -0.34 -6.31 -0.33 8.87e-10 IgG glycosylation; LUSC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg22823121 chr1:150693482 HORMAD1 0.48 7.06 0.36 9.78e-12 Melanoma; LUSC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg03806693 chr22:41940476 POLR3H -0.96 -13.6 -0.6 8e-34 Vitiligo; LUSC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.37 6.03 0.31 4.26e-9 Self-reported allergy; LUSC cis rs17014483 1.000 rs2278877 chr4:89668210 G/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.65 5.81 0.3 1.43e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7640424 0.721 rs326355 chr3:107824663 T/C cg09227934 chr3:107805635 CD47 0.38 6.02 0.31 4.55e-9 Body mass index; LUSC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg25282410 chr6:160211355 TCP1;MRPL18 1.08 16.32 0.67 1.97e-44 Age-related macular degeneration (geographic atrophy); LUSC cis rs796364 0.616 rs2140486 chr2:200690102 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.91 0.31 8.39e-9 Schizophrenia; LUSC cis rs7605827 0.930 rs7574879 chr2:15698083 C/G cg19274914 chr2:15703543 NA 0.48 9.2 0.45 3.97e-18 Educational attainment (years of education); LUSC trans rs62238980 0.614 rs117628874 chr22:32452970 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg00750074 chr16:89608354 SPG7 -0.53 -9.59 -0.46 2.13e-19 Multiple myeloma (IgH translocation); LUSC cis rs6076065 0.925 rs2281430 chr20:23399314 T/C cg11657817 chr20:23433608 CST11 0.46 8.9 0.44 3.7e-17 Facial morphology (factor 15, philtrum width); LUSC cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg14844989 chr11:31128820 NA -0.37 -5.75 -0.3 2e-8 Red blood cell count; LUSC cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg26384229 chr12:38710491 ALG10B 0.84 14.47 0.62 3.51e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg11941060 chr3:133502564 NA -0.46 -6.66 -0.34 1.11e-10 Iron status biomarkers; LUSC cis rs11031096 0.782 rs2284450 chr11:4149214 A/T cg18678763 chr11:4115507 RRM1 -0.53 -7.58 -0.38 3.43e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg02038168 chr22:39784481 NA -0.46 -6.9 -0.35 2.55e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2235649 0.833 rs9939766 chr16:1852808 C/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.44 -6.02 -0.31 4.57e-9 Blood metabolite levels; LUSC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.89 0.55 2.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1670533 1.000 rs13134921 chr4:1054177 A/G cg02018176 chr4:1364513 KIAA1530 0.44 6.08 0.32 3.24e-9 Recombination rate (females); LUSC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg13647721 chr17:30228624 UTP6 0.58 5.66 0.3 3.23e-8 Hip circumference adjusted for BMI; LUSC cis rs1348850 0.918 rs12463893 chr2:178448559 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 6.82 0.35 4.18e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg11843238 chr5:131593191 PDLIM4 0.37 6.32 0.33 8.44e-10 Breast cancer; LUSC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7605827 0.930 rs12692272 chr2:15680801 C/T cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.27e-17 Educational attainment (years of education); LUSC cis rs3892630 0.817 rs35408716 chr19:33187961 A/C cg22980127 chr19:33182716 NUDT19 0.94 12.81 0.57 7.79e-31 Red blood cell traits; LUSC cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg06784218 chr1:46089804 CCDC17 -0.52 -9.87 -0.48 2.51e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12493885 0.818 rs10935971 chr3:153773945 C/T cg17054900 chr3:154042577 DHX36 -0.74 -7.55 -0.38 4.06e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg14159672 chr1:205819179 PM20D1 0.53 8.71 0.43 1.43e-16 Menarche (age at onset); LUSC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg05347473 chr6:146136440 FBXO30 -0.58 -10.07 -0.48 5.2e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs9560113 0.959 rs4773385 chr13:112178452 C/T cg14154082 chr13:112174009 NA 0.38 7.76 0.39 1.03e-13 Menarche (age at onset); LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.22 0.52 5.23e-25 Menopause (age at onset); LUSC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg17385448 chr1:15911702 AGMAT 0.37 6.23 0.32 1.41e-9 Systolic blood pressure; LUSC cis rs8114671 0.562 rs2064454 chr20:33496169 C/T cg07148914 chr20:33460835 GGT7 0.57 8.6 0.43 3.21e-16 Height; LUSC cis rs34734847 1.000 rs56273049 chr12:121156041 A/T cg21892295 chr12:121157589 UNC119B -0.52 -9.38 -0.46 1.01e-18 Mean corpuscular volume; LUSC cis rs7824557 0.564 rs2736293 chr8:11234613 T/A cg21775007 chr8:11205619 TDH -0.65 -10.2 -0.49 1.94e-21 Retinal vascular caliber; LUSC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg01475377 chr6:109611718 NA -0.47 -8.64 -0.43 2.29e-16 Reticulocyte fraction of red cells; LUSC cis rs9341808 0.935 rs1535825 chr6:80938586 C/T cg08355045 chr6:80787529 NA -0.48 -8.73 -0.43 1.21e-16 Sitting height ratio; LUSC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC cis rs12545109 0.765 rs2576594 chr8:57412126 T/G cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.11e-10 Obesity-related traits; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13906968 chr16:29831676 MVP;C16orf53 -0.45 -6.16 -0.32 2.04e-9 Hepatitis; LUSC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs3087591 0.960 rs7212264 chr17:29454766 C/T cg24425628 chr17:29625626 OMG;NF1 0.56 7.93 0.4 3.23e-14 Hip circumference; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg06815965 chr1:205818668 PM20D1 0.39 6.08 0.32 3.28e-9 Menarche (age at onset); LUSC trans rs57046232 0.552 rs1571216 chr20:6316328 A/C cg17788362 chr6:86352627 SYNCRIP -0.45 -6.3 -0.33 9.25e-10 Colorectal cancer; LUSC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg14019146 chr3:50243930 SLC38A3 0.32 7.09 0.36 8.27e-12 Intelligence (multi-trait analysis); LUSC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg04998671 chr14:104000505 TRMT61A -0.42 -5.94 -0.31 7.19e-9 Reticulocyte count; LUSC cis rs7582720 0.887 rs115600411 chr2:204121145 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.75 7.92 0.4 3.68e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs8017423 0.935 rs2149653 chr14:90669333 G/A cg14092571 chr14:90743983 NA -0.35 -5.77 -0.3 1.84e-8 Mortality in heart failure; LUSC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg09165964 chr15:75287851 SCAMP5 0.5 7.38 0.37 1.3e-12 Breast cancer; LUSC cis rs8017423 0.935 rs7158410 chr14:90704370 T/C cg04374321 chr14:90722782 PSMC1 0.76 12.09 0.55 3.72e-28 Mortality in heart failure; LUSC cis rs7809950 0.861 rs2701682 chr7:107295835 G/A cg23024343 chr7:107201750 COG5 0.67 9.39 0.46 9.57e-19 Coronary artery disease; LUSC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg01416388 chr22:39784598 NA -0.42 -6.94 -0.35 2.11e-11 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg02034447 chr16:89574710 SPG7 0.44 6.33 0.33 7.95e-10 Multiple myeloma (IgH translocation); LUSC cis rs11190604 1.000 rs11190558 chr10:102209397 C/A cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7923452 0.938 rs753173 chr10:30778738 T/C cg25182066 chr10:30743637 MAP3K8 0.58 6.58 0.34 1.8e-10 Itch intensity from mosquito bite; LUSC cis rs4363385 0.510 rs6673356 chr1:153041903 C/T cg00922841 chr1:152955080 SPRR1A 0.37 6.26 0.32 1.2e-9 Inflammatory skin disease; LUSC cis rs3815700 1.000 rs8109885 chr19:33095557 A/G cg02997394 chr19:33096574 ANKRD27 0.8 9.1 0.45 8.16e-18 Eosinophilic esophagitis; LUSC cis rs225245 0.817 rs1634684 chr17:33941051 A/G cg05299278 chr17:33885742 SLFN14 0.31 6.81 0.35 4.51e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs17507216 1.000 rs17356118 chr15:83237899 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.45 -6.3 -0.33 9.65e-10 Excessive daytime sleepiness; LUSC cis rs7264396 0.563 rs2225950 chr20:34333015 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.35 -0.42 1.87e-15 Total cholesterol levels; LUSC cis rs6906287 0.647 rs6569020 chr6:118795522 C/T cg21191810 chr6:118973309 C6orf204 0.32 5.79 0.3 1.63e-8 Electrocardiographic conduction measures; LUSC cis rs11190604 1.000 rs2495737 chr10:102338344 T/C cg07080220 chr10:102295463 HIF1AN 0.68 9.07 0.44 1.04e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7267979 1.000 rs2027004 chr20:25350618 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.51 -0.34 2.81e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7809950 0.817 rs4727678 chr7:107083635 C/G cg23024343 chr7:107201750 COG5 -0.71 -10.45 -0.5 2.73e-22 Coronary artery disease; LUSC cis rs1451375 0.657 rs7802148 chr7:50648284 T/C cg18232548 chr7:50535776 DDC 0.5 7.58 0.38 3.49e-13 Malaria; LUSC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg13607699 chr17:42295918 UBTF 0.5 7.83 0.39 6.75e-14 Total body bone mineral density; LUSC cis rs4664308 0.594 rs4665141 chr2:160890795 A/T cg03641300 chr2:160917029 PLA2R1 -0.48 -8.0 -0.4 2.13e-14 Idiopathic membranous nephropathy; LUSC cis rs12893668 0.703 rs2274267 chr14:104029449 G/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -5.95 -0.31 6.69e-9 Reticulocyte count; LUSC cis rs4888262 0.545 rs8052923 chr16:74680105 C/T cg01733217 chr16:74700730 RFWD3 0.79 12.98 0.58 1.72e-31 Testicular germ cell tumor; LUSC cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC cis rs7178572 0.568 rs4243045 chr15:77455914 A/C cg22256960 chr15:77711686 NA -0.5 -7.95 -0.4 2.97e-14 Type 2 diabetes; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg03579872 chr1:53393473 SCP2 0.39 5.72 0.3 2.35e-8 Monocyte count; LUSC trans rs10506458 1.000 rs17763435 chr12:63416511 A/G cg22491629 chr6:157744540 C6orf35 0.85 10.24 0.49 1.43e-21 Hemostatic factors and hematological phenotypes; LUSC cis rs1983170 0.736 rs12127718 chr1:91997490 A/T cg25838465 chr1:92012736 NA 0.47 5.97 0.31 5.96e-9 Eosinophil percentage of white cells; LUSC cis rs7189233 0.955 rs8058684 chr16:53515118 G/A cg09728985 chr16:53543985 NA -0.34 -6.21 -0.32 1.55e-9 Intelligence (multi-trait analysis); LUSC cis rs3020736 0.500 rs2839708 chr22:42500745 A/G cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg02153584 chr22:29168773 CCDC117 0.57 8.9 0.44 3.57e-17 Lymphocyte counts; LUSC cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg05768032 chr16:30646687 NA 0.4 5.94 0.31 7.1e-9 Multiple myeloma; LUSC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6494488 0.500 rs34758599 chr15:64706332 A/G cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Coronary artery disease; LUSC cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg13256891 chr4:100009986 ADH5 -0.43 -6.0 -0.31 5.06e-9 Alcohol dependence; LUSC trans rs7939886 0.920 rs11227180 chr11:55855611 G/C cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg18196295 chr10:418757 DIP2C -0.43 -6.52 -0.34 2.54e-10 Psychosis in Alzheimer's disease; LUSC cis rs9486719 0.857 rs4265039 chr6:96878929 T/C cg06623918 chr6:96969491 KIAA0776 0.79 11.74 0.54 6.98e-27 Migraine;Coronary artery disease; LUSC cis rs7212590 0.529 rs60283440 chr17:57994248 T/C cg10252138 chr17:58120427 NA -0.78 -7.19 -0.37 4.2e-12 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs2273669 0.667 rs12212402 chr6:109306681 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs7267979 0.873 rs6083853 chr20:25404541 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.61 -0.34 1.53e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10779751 0.734 rs1130683 chr1:11132217 G/A cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg03146154 chr1:46216737 IPP -0.51 -7.7 -0.39 1.6e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7520050 0.807 rs28844317 chr1:46209207 T/C cg06784218 chr1:46089804 CCDC17 0.3 5.95 0.31 6.92e-9 Red blood cell count;Reticulocyte count; LUSC cis rs1461503 0.512 rs3816621 chr11:122818311 A/G cg27398637 chr11:122830231 C11orf63 -0.39 -6.47 -0.33 3.59e-10 Menarche (age at onset); LUSC cis rs3892630 0.818 rs80137870 chr19:33182750 C/T cg22980127 chr19:33182716 NUDT19 0.94 12.81 0.57 8.08e-31 Red blood cell traits; LUSC cis rs4662750 0.619 rs2244042 chr2:128404998 A/G cg03462943 chr2:128407068 GPR17;LIMS2 -0.39 -6.24 -0.32 1.36e-9 Renal cell carcinoma; LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -11.37 -0.53 1.48e-25 Platelet count; LUSC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg20307385 chr11:47447363 PSMC3 -0.46 -5.89 -0.31 9.27e-9 Subjective well-being; LUSC cis rs2191566 0.960 rs367209 chr19:44506249 A/G cg03039196 chr19:44506973 ZNF230 -0.38 -6.1 -0.32 2.93e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.19 -0.49 2.13e-21 Platelet count; LUSC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg00343986 chr7:65444356 GUSB -0.46 -6.8 -0.35 4.74e-11 Aortic root size; LUSC trans rs4252134 0.687 rs45475797 chr6:161237891 G/A cg15977026 chr12:53661908 ESPL1 -0.51 -5.97 -0.31 6.18e-9 Giant cell arteritis; LUSC trans rs35110281 0.712 rs162345 chr21:44954155 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.97 0.48 1.18e-20 Mean corpuscular volume; LUSC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.94 -0.35 2.1e-11 Total body bone mineral density; LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.23 0.56 1.09e-28 Prudent dietary pattern; LUSC cis rs8114671 0.904 rs6060197 chr20:33654315 C/T cg24642439 chr20:33292090 TP53INP2 -0.41 -5.89 -0.31 9.23e-9 Height; LUSC cis rs6977660 1.000 rs12673970 chr7:19813018 T/C cg07541023 chr7:19748670 TWISTNB 0.54 6.17 0.32 1.99e-9 Thyroid stimulating hormone; LUSC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg13206674 chr6:150067644 NUP43 0.62 10.17 0.49 2.43e-21 Lung cancer; LUSC cis rs8114671 0.869 rs6060199 chr20:33654773 A/G cg07148914 chr20:33460835 GGT7 -0.46 -6.74 -0.35 7.17e-11 Height; LUSC cis rs7918232 0.943 rs6482593 chr10:27371437 A/G cg14240646 chr10:27532245 ACBD5 -0.64 -7.55 -0.38 4.27e-13 Breast cancer; LUSC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg20811857 chr17:78079795 GAA 0.46 7.94 0.4 3.01e-14 Yeast infection; LUSC cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs240764 0.658 rs12174806 chr6:101219581 C/T cg09795085 chr6:101329169 ASCC3 -0.44 -5.89 -0.31 9.4e-9 Neuroticism; LUSC cis rs8017423 0.935 rs7154695 chr14:90795705 C/G cg14092571 chr14:90743983 NA -0.4 -6.73 -0.35 7.55e-11 Mortality in heart failure; LUSC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.76 0.3 1.93e-8 Tonsillectomy; LUSC cis rs250677 0.524 rs40521 chr5:148439639 C/T cg12140854 chr5:148520817 ABLIM3 0.34 6.32 0.33 8.42e-10 Breast cancer; LUSC cis rs10861661 0.569 rs10778514 chr12:107303577 G/A cg13944111 chr12:107296891 NA 0.37 6.5 0.34 2.91e-10 Triglyceride levels; LUSC cis rs6502050 0.787 rs8080682 chr17:80058901 G/A cg13939156 chr17:80058883 NA 0.37 7.44 0.38 8.81e-13 Life satisfaction; LUSC cis rs4629180 0.675 rs10183203 chr2:102095080 C/T cg01388757 chr2:102091195 RFX8 0.35 5.97 0.31 6.09e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg05084668 chr3:125655381 ALG1L 0.48 6.8 0.35 4.73e-11 Blood pressure (smoking interaction); LUSC cis rs7465272 1.000 rs7835613 chr8:143682428 C/T cg10104451 chr8:143696006 ARC -0.61 -8.74 -0.43 1.18e-16 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.42 0.69 8.19e-49 Chronic sinus infection; LUSC trans rs208520 1.000 rs12195505 chr6:66986279 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.63 -0.57 3.55e-30 Chronic sinus infection; LUSC cis rs2463822 0.583 rs72919467 chr11:62040102 G/A cg06239285 chr11:62104954 ASRGL1 -0.59 -6.0 -0.31 5.11e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg21545522 chr1:205238299 TMCC2 0.49 9.2 0.45 3.93e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs977987 0.806 rs6564258 chr16:75447363 G/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.62 -0.34 1.4e-10 Dupuytren's disease; LUSC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.84 -0.47 3.09e-20 Gut microbiome composition (summer); LUSC trans rs12165098 0.636 rs4287637 chr18:36744896 T/C cg23858286 chr9:138135095 NA -0.42 -6.09 -0.32 3.15e-9 Sleep duration; LUSC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.23 -0.32 1.42e-9 Developmental language disorder (linguistic errors); LUSC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg14019146 chr3:50243930 SLC38A3 0.37 8.29 0.41 2.88e-15 Body mass index; LUSC cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg05347473 chr6:146136440 FBXO30 0.47 8.03 0.4 1.63e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg09640425 chr7:158790006 NA -0.53 -8.51 -0.42 6.11e-16 Facial morphology (factor 20); LUSC cis rs6087990 1.000 rs2018002 chr20:31351623 A/T cg13636640 chr20:31349939 DNMT3B 1.06 24.53 0.8 1.02e-76 Ulcerative colitis; LUSC cis rs4077515 0.839 rs10781518 chr9:139300547 C/T cg14169450 chr9:139327907 INPP5E -0.42 -7.2 -0.37 4.09e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs5758511 0.573 rs1883205 chr22:42243020 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.39 -7.51 -0.38 5.28e-13 Birth weight; LUSC cis rs4631830 0.720 rs7090326 chr10:51503375 A/T cg20129853 chr10:51489980 NA -0.35 -7.17 -0.37 4.86e-12 Prostate-specific antigen levels; LUSC cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.44 6.62 0.34 1.47e-10 Systemic lupus erythematosus; LUSC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg24977027 chr2:88469347 THNSL2 0.57 5.83 0.3 1.3e-8 Plasma clusterin levels; LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg06873352 chr17:61820015 STRADA 0.72 13.02 0.58 1.22e-31 Prudent dietary pattern; LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7953249 0.656 rs2178463 chr12:121389721 A/G cg25281562 chr12:121454272 C12orf43 -0.44 -5.87 -0.31 1.07e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs611744 0.573 rs674580 chr8:109251690 C/G cg21045802 chr8:109455806 TTC35 0.46 7.15 0.36 5.42e-12 Dupuytren's disease; LUSC cis rs1801251 1.000 rs283486 chr2:233644223 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.49 0.33 3.17e-10 Coronary artery disease; LUSC cis rs7759001 0.857 rs2393931 chr6:27353114 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg06915202 chr7:98029285 BAIAP2L1 0.31 6.15 0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06022373 chr22:39101656 GTPBP1 0.71 11.13 0.52 1.1e-24 Menopause (age at onset); LUSC cis rs7107174 0.901 rs7110387 chr11:78117875 A/G cg02023728 chr11:77925099 USP35 0.44 6.37 0.33 6.19e-10 Testicular germ cell tumor; LUSC cis rs7100689 0.646 rs11202725 chr10:82136276 A/G cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg12963246 chr6:28129442 ZNF389 -0.48 -6.86 -0.35 3.3e-11 Depression; LUSC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg06656553 chr16:89960601 TCF25 -0.55 -5.66 -0.3 3.24e-8 Skin colour saturation; LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg25036284 chr2:26402008 FAM59B 0.79 11.11 0.52 1.26e-24 Mean corpuscular hemoglobin; LUSC cis rs12586317 0.620 rs28404080 chr14:35539418 G/T cg05294307 chr14:35346193 BAZ1A -0.57 -6.87 -0.35 3.07e-11 Psoriasis; LUSC trans rs1997103 0.954 rs56030000 chr7:55405750 A/G cg20935933 chr6:143382018 AIG1 0.5 7.27 0.37 2.61e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4820539 0.966 rs5759594 chr22:23470660 G/A cg14186256 chr22:23484241 RTDR1 0.95 18.06 0.7 2.27e-51 Bone mineral density; LUSC cis rs6964587 1.000 rs9784993 chr7:91672403 G/A cg22709100 chr7:91322751 NA 0.39 5.79 0.3 1.64e-8 Breast cancer; LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg08736216 chr1:53307985 ZYG11A 0.29 6.03 0.31 4.36e-9 Monocyte count; LUSC cis rs28655083 0.828 rs9938028 chr16:77127830 A/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.49 7.59 0.38 3.1400000000000003e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg09997546 chr11:8931473 C11orf17;ST5 -0.36 -7.57 -0.38 3.68e-13 Hemoglobin concentration; LUSC cis rs12545109 0.765 rs2055985 chr8:57410821 T/A cg09654669 chr8:57350985 NA -0.58 -7.88 -0.4 4.68e-14 Obesity-related traits; LUSC cis rs1595825 0.891 rs16823385 chr2:198602101 G/A cg19156104 chr2:198669113 PLCL1 -0.49 -5.88 -0.31 9.82e-9 Ulcerative colitis; LUSC cis rs1682825 0.547 rs17028925 chr3:10777632 A/G cg23512531 chr3:10780469 NA 0.43 5.68 0.3 2.94e-8 Economic and political preferences (feminism/equality); LUSC cis rs738321 0.757 rs3788534 chr22:38533971 A/T cg25457927 chr22:38595422 NA -0.37 -7.23 -0.37 3.26e-12 Breast cancer; LUSC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg00999904 chr2:3704751 ALLC 0.43 7.2 0.37 4.13e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs6960043 0.818 rs10950546 chr7:15050391 C/T cg19272540 chr7:15055459 NA 0.35 8.48 0.42 7.62e-16 Type 2 diabetes; LUSC trans rs7939886 0.920 rs12223014 chr11:55878290 G/A cg15704280 chr7:45808275 SEPT13 0.79 6.68 0.34 9.84e-11 Myopia (pathological); LUSC cis rs11650494 0.710 rs16948071 chr17:47468706 T/G cg08112188 chr17:47440006 ZNF652 1.07 8.75 0.43 1.07e-16 Prostate cancer; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 3.1e-34 Prudent dietary pattern; LUSC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg00310523 chr12:86230176 RASSF9 0.52 9.81 0.47 3.84e-20 Major depressive disorder; LUSC cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg00484396 chr16:3507460 NAT15 -0.47 -6.93 -0.35 2.18e-11 Body mass index (adult); LUSC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.2 -0.32 1.69e-9 Total body bone mineral density; LUSC cis rs79349575 0.783 rs15563 chr17:47005193 A/G cg22482690 chr17:47019901 SNF8 0.37 6.96 0.36 1.86e-11 Type 2 diabetes; LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg02475777 chr4:1388615 CRIPAK 0.41 6.12 0.32 2.62e-9 Obesity-related traits; LUSC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg19077165 chr18:44547161 KATNAL2 -0.43 -6.29 -0.33 1e-9 Personality dimensions; LUSC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg20476274 chr7:133979776 SLC35B4 0.85 15.95 0.66 5.43e-43 Mean platelet volume; LUSC cis rs7605827 0.930 rs13384921 chr2:15602840 C/T cg19274914 chr2:15703543 NA 0.45 8.74 0.43 1.12e-16 Educational attainment (years of education); LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg12419862 chr22:24373484 LOC391322 -0.89 -15.78 -0.65 2.64e-42 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7264396 0.561 rs6142474 chr20:34574914 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.71 0.34 8.22e-11 Total cholesterol levels; LUSC cis rs6496667 0.683 rs2589973 chr15:90892293 C/T cg03599575 chr15:90893182 GABARAPL3 0.35 5.78 0.3 1.73e-8 Rheumatoid arthritis; LUSC cis rs9926296 0.744 rs460984 chr16:89713174 C/T cg03605463 chr16:89740564 NA 0.6 9.36 0.46 1.22e-18 Vitiligo; LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg14092988 chr3:52407081 DNAH1 0.31 5.92 0.31 7.82e-9 Bipolar disorder; LUSC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg21285383 chr16:89894308 SPIRE2 0.35 7.33 0.37 1.76e-12 Vitiligo; LUSC cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg22875332 chr1:76189707 ACADM -0.42 -6.31 -0.33 8.94e-10 Daytime sleep phenotypes; LUSC trans rs459571 0.959 rs465535 chr9:136910905 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -12.35 -0.56 4.11e-29 Platelet distribution width; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg08859206 chr1:53392774 SCP2 -0.55 -9.72 -0.47 8.16e-20 Monocyte count; LUSC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.53 0.38 4.76e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg16928487 chr17:17741425 SREBF1 0.47 9.2 0.45 3.98e-18 Total body bone mineral density; LUSC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg02709834 chr1:75198841 CRYZ;TYW3 0.38 5.81 0.3 1.46e-8 Resistin levels; LUSC cis rs8072100 1.000 rs7210738 chr17:45757598 G/A cg25173405 chr17:45401733 C17orf57 0.38 6.13 0.32 2.52e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11267619 chr7:29604021 PRR15 -0.38 -6.04 -0.31 4.08e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7584330 0.737 rs13397017 chr2:238361241 G/A cg14458575 chr2:238380390 NA 0.68 12.14 0.55 2.41e-28 Prostate cancer; LUSC cis rs4919694 1.000 rs12253284 chr10:104665145 G/C cg04362960 chr10:104952993 NT5C2 1.1 12.9 0.58 3.57e-31 Arsenic metabolism; LUSC cis rs62400317 0.859 rs12198376 chr6:45153681 G/C cg18551225 chr6:44695536 NA -0.42 -6.87 -0.35 3.24e-11 Total body bone mineral density; LUSC cis rs950027 0.596 rs2467853 chr15:45698793 T/G cg14582100 chr15:45693742 SPATA5L1 0.45 8.34 0.42 1.95e-15 Response to fenofibrate (adiponectin levels); LUSC cis rs2073300 0.609 rs1936011 chr20:23341912 G/C cg12062639 chr20:23401060 NAPB 0.96 8.01 0.4 1.94e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7582180 0.625 rs11892034 chr2:100938952 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.35 -0.42 1.82e-15 Intelligence (multi-trait analysis); LUSC cis rs10823500 0.636 rs7082396 chr10:71945511 C/A cg02100629 chr10:71892760 AIFM2 -0.41 -6.88 -0.35 2.97e-11 Blood protein levels; LUSC cis rs13401104 0.796 rs719544 chr2:237118282 A/C cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg06784218 chr1:46089804 CCDC17 -0.47 -8.88 -0.44 4.2e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg12615879 chr12:58013172 SLC26A10 -0.3 -6.38 -0.33 5.76e-10 Multiple sclerosis; LUSC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg12310025 chr6:25882481 NA 0.41 6.79 0.35 5.02e-11 Intelligence (multi-trait analysis); LUSC cis rs11051970 0.879 rs2728669 chr12:32590651 C/T cg02745156 chr12:32552066 NA 0.42 7.12 0.36 6.75e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg01579765 chr21:45077557 HSF2BP -0.54 -11.29 -0.53 2.97e-25 Mean corpuscular volume; LUSC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg23283495 chr1:209979779 IRF6 0.39 6.03 0.31 4.24e-9 Monobrow; LUSC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg08219700 chr8:58056026 NA 0.5 6.24 0.32 1.32e-9 Developmental language disorder (linguistic errors); LUSC cis rs8027181 0.959 rs11631352 chr15:73086473 A/G cg25632853 chr15:73088954 NA -0.34 -6.79 -0.35 5.16e-11 Triglyceride levels; LUSC cis rs6570726 0.905 rs377143 chr6:145834220 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.38 0.33 5.87e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.545 rs12444313 chr16:68254404 A/C cg05110241 chr16:68378359 PRMT7 -0.64 -6.99 -0.36 1.46e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs12042107 0.818 rs6428600 chr1:91192297 C/G cg13456504 chr1:91191583 NA 0.43 7.21 0.37 3.87e-12 Educational attainment; LUSC cis rs7683537 0.692 rs56368159 chr4:185654827 T/G cg07424746 chr4:185654737 MLF1IP -0.52 -5.76 -0.3 1.95e-8 Systemic lupus erythematosus; LUSC cis rs1949733 0.656 rs2688243 chr4:8436286 A/G cg11789530 chr4:8429930 ACOX3 0.57 9.12 0.45 7.26e-18 Response to antineoplastic agents; LUSC cis rs868036 0.681 rs28670272 chr15:68109907 C/T cg27219399 chr15:67835830 MAP2K5 -0.36 -6.05 -0.31 3.92e-9 Restless legs syndrome; LUSC cis rs709400 1.000 rs55885592 chr14:104126024 C/T cg24130564 chr14:104152367 KLC1 -0.51 -7.43 -0.38 9.17e-13 Body mass index; LUSC cis rs6977660 1.000 rs13231036 chr7:19806141 G/A cg07541023 chr7:19748670 TWISTNB 0.53 6.09 0.32 3.14e-9 Thyroid stimulating hormone; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.54 8.37 0.42 1.63e-15 Lymphocyte counts; LUSC cis rs7572644 0.553 rs4233717 chr2:28034680 A/T cg27432699 chr2:27873401 GPN1 0.58 7.38 0.37 1.26e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9399135 0.967 rs2327580 chr6:135364417 A/C cg22676075 chr6:135203613 NA 0.46 7.13 0.36 6.1e-12 Red blood cell count; LUSC cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg24130564 chr14:104152367 KLC1 -0.49 -7.78 -0.39 9.15e-14 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg10150615 chr22:24372951 LOC391322 -0.38 -6.32 -0.33 8.35e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.01 0.44 1.64e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg07936489 chr17:37558343 FBXL20 -0.72 -9.91 -0.48 1.76e-20 Glomerular filtration rate (creatinine); LUSC trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg25482853 chr8:67687455 SGK3 1.2 17.16 0.68 9.11e-48 Lung disease severity in cystic fibrosis; LUSC cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg05347473 chr6:146136440 FBXO30 0.53 9.08 0.44 1e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs1372520 1.000 rs1372520 chr4:90757505 T/C cg15133208 chr4:90757351 SNCA -0.56 -8.46 -0.42 8.77e-16 Neuroticism; LUSC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg09034736 chr1:150693464 HORMAD1 0.4 5.72 0.3 2.37e-8 Melanoma; LUSC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.48 0.46 5e-19 Mean platelet volume; LUSC cis rs68170813 0.559 rs7793594 chr7:106891829 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg05347473 chr6:146136440 FBXO30 0.52 8.74 0.43 1.13e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.71 0.54 9.35e-27 Alzheimer's disease; LUSC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.62e-13 Bipolar disorder; LUSC cis rs727505 1.000 rs9655845 chr7:124513355 G/C cg23710748 chr7:124431027 NA -0.41 -7.39 -0.38 1.16e-12 Lewy body disease; LUSC cis rs9309473 1.000 rs7584575 chr2:73666402 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.49 -0.33 3.07e-10 Metabolite levels; LUSC cis rs4595586 0.525 rs10506132 chr12:39404599 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.58 0.38 3.43e-13 Morning vs. evening chronotype; LUSC cis rs2486288 0.656 rs1719236 chr15:45577783 G/T cg26924012 chr15:45694286 SPATA5L1 -0.65 -8.57 -0.42 3.93e-16 Glomerular filtration rate; LUSC cis rs6961069 0.585 rs10268417 chr7:80239837 C/A cg04458919 chr7:80252533 CD36 -0.4 -7.32 -0.37 1.91e-12 Platelet count; LUSC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg11764359 chr7:65958608 NA -0.7 -10.79 -0.51 1.74e-23 Aortic root size; LUSC cis rs6964587 1.000 rs12540055 chr7:91707921 A/G cg22709100 chr7:91322751 NA 0.39 5.77 0.3 1.86e-8 Breast cancer; LUSC cis rs116095464 0.558 rs6879656 chr5:264428 T/C cg22857025 chr5:266934 NA -1.14 -14.7 -0.63 4.52e-38 Breast cancer; LUSC cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg00071950 chr4:10020882 SLC2A9 0.46 7.49 0.38 6.08e-13 Bone mineral density; LUSC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.53 0.5 1.44e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg13256891 chr4:100009986 ADH5 -0.45 -6.23 -0.32 1.43e-9 Alcohol dependence; LUSC cis rs12618769 0.597 rs961242 chr2:99138979 G/A cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg08499158 chr17:42289980 UBTF 0.41 6.28 0.32 1.05e-9 Total body bone mineral density; LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg02018176 chr4:1364513 KIAA1530 0.51 8.98 0.44 1.99e-17 Obesity-related traits; LUSC cis rs2267681 0.544 rs10237429 chr7:139528596 C/G cg14116596 chr7:139528673 TBXAS1 0.36 6.23 0.32 1.42e-9 Cervical cancer; LUSC cis rs28647808 0.881 rs71483207 chr9:136258698 A/G cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg21782813 chr7:2030301 MAD1L1 0.48 8.02 0.4 1.84e-14 Bipolar disorder and schizophrenia; LUSC cis rs6700896 0.966 rs11208689 chr1:66083197 G/A cg04111102 chr1:66153794 NA 0.31 6.92 0.35 2.3e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg14552801 chr7:65878734 NA -0.37 -5.68 -0.3 2.97e-8 Aortic root size; LUSC cis rs12220238 1.000 rs11000894 chr10:75906598 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.96 0.36 1.79e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.34 0.37 1.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9296092 0.538 rs115770720 chr6:33517032 A/T cg13560919 chr6:33536144 NA -0.82 -15.73 -0.65 4.02e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg03161606 chr19:29218774 NA 0.6 8.79 0.43 7.77e-17 Methadone dose in opioid dependence; LUSC cis rs7615316 0.902 rs6799752 chr3:142311712 T/C cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.58e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2282032 0.527 rs57011283 chr14:90767165 G/T cg04374321 chr14:90722782 PSMC1 0.44 6.14 0.32 2.32e-9 Longevity; LUSC cis rs73416724 1.000 rs75782458 chr6:43340810 G/A cg26312998 chr6:43337775 ZNF318 0.57 6.62 0.34 1.4e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs6087990 0.735 rs2064350 chr20:31390533 T/C cg13636640 chr20:31349939 DNMT3B 0.93 18.92 0.72 9.01e-55 Ulcerative colitis; LUSC cis rs11190604 0.943 rs113791644 chr10:102324330 T/G cg16342193 chr10:102329863 NA -0.37 -6.31 -0.33 9.07e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7223966 1.000 rs7217982 chr17:61832150 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.98 0.36 1.62e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg23711669 chr6:146136114 FBXO30 0.76 13.72 0.6 2.76e-34 Lobe attachment (rater-scored or self-reported); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25958857 chr12:53448399 TENC1 -0.37 -7.05 -0.36 1.02e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1044826 0.642 rs6787649 chr3:139193321 C/T cg00490450 chr3:139108681 COPB2 0.46 7.02 0.36 1.27e-11 Obesity-related traits; LUSC cis rs2073300 1.000 rs74273799 chr20:23444492 T/C cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg04369109 chr6:150039330 LATS1 -0.58 -8.59 -0.43 3.3e-16 Lung cancer; LUSC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg17261708 chr5:176794207 RGS14 0.33 5.72 0.3 2.43e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg15445000 chr17:37608096 MED1 0.38 6.52 0.34 2.54e-10 Glomerular filtration rate (creatinine); LUSC cis rs1797081 0.811 rs1797076 chr10:16853076 A/G cg23933602 chr10:16859644 RSU1 0.91 19.01 0.72 3.92e-55 Platelet distribution width; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00021166 chr12:27676702 PPFIBP1 0.42 6.61 0.34 1.57e-10 Triglycerides; LUSC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11644478 chr21:40555479 PSMG1 0.95 19.4 0.73 1.07e-56 Cognitive function; LUSC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg24690094 chr11:67383802 NA 0.52 11.03 0.52 2.4e-24 Mean corpuscular volume; LUSC trans rs7980799 0.654 rs1482987 chr12:33614283 G/C cg26384229 chr12:38710491 ALG10B -0.58 -8.7 -0.43 1.5e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1185460 0.967 rs1177563 chr11:118949083 C/T cg23280166 chr11:118938394 VPS11 0.48 7.43 0.38 9.21e-13 Coronary artery disease; LUSC cis rs4555082 0.834 rs28489970 chr14:105748862 T/C cg06808227 chr14:105710500 BRF1 -0.6 -8.7 -0.43 1.58e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg13206674 chr6:150067644 NUP43 0.56 8.68 0.43 1.76e-16 Lung cancer; LUSC trans rs6480314 0.542 rs12572967 chr10:70030630 G/A cg04882175 chr6:131122610 NA -0.54 -6.19 -0.32 1.77e-9 Optic nerve measurement (disc area); LUSC cis rs7107174 1.000 rs11237460 chr11:78056274 G/A cg02023728 chr11:77925099 USP35 0.43 6.59 0.34 1.68e-10 Testicular germ cell tumor; LUSC cis rs1595825 0.786 rs1902247 chr2:198492826 C/T cg00982548 chr2:198649783 BOLL -0.51 -6.54 -0.34 2.3e-10 Ulcerative colitis; LUSC cis rs6594499 0.872 rs10038058 chr5:110443281 A/G cg04022379 chr5:110408740 TSLP 0.41 6.05 0.31 3.96e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1639906 0.965 rs1637742 chr7:2236432 G/A cg18044113 chr7:2236405 MAD1L1 -0.31 -5.9 -0.31 8.71e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs931127 0.658 rs4244812 chr11:65480768 A/G cg05805236 chr11:65401703 PCNXL3 -0.45 -7.56 -0.38 3.96e-13 Systemic lupus erythematosus; LUSC cis rs13082711 0.555 rs7627508 chr3:27252495 A/C cg02860705 chr3:27208620 NA 0.67 11.7 0.54 1.01e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg20476274 chr7:133979776 SLC35B4 0.83 15.23 0.64 3.81e-40 Mean platelet volume; LUSC cis rs7091068 0.616 rs6583905 chr10:95504022 T/G cg20715218 chr10:95462985 C10orf4 0.61 6.69 0.34 9.4e-11 Urinary tract infection frequency; LUSC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg07936489 chr17:37558343 FBXL20 -0.73 -10.03 -0.48 7.03e-21 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg23711669 chr6:146136114 FBXO30 0.82 14.57 0.62 1.5e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg04455712 chr21:45112962 RRP1B 0.45 8.44 0.42 9.65e-16 Mean corpuscular volume; LUSC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg12963246 chr6:28129442 ZNF389 0.52 7.18 0.37 4.53e-12 Depression; LUSC cis rs6951245 0.572 rs79396168 chr7:1048928 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -6.38 -0.33 5.82e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4363385 0.818 rs653332 chr1:153010481 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.67e-12 Inflammatory skin disease; LUSC cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg00745463 chr17:30367425 LRRC37B -0.8 -8.52 -0.42 5.56e-16 Hip circumference adjusted for BMI; LUSC cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg17420585 chr12:42539391 GXYLT1 -0.37 -7.35 -0.37 1.54e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7220711 1.000 rs12602349 chr17:41792236 T/C cg26893861 chr17:41843967 DUSP3 0.42 5.88 0.31 9.89e-9 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg08200582 chr11:442649 ANO9 -0.53 -5.74 -0.3 2.07e-8 Body mass index; LUSC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg06022373 chr22:39101656 GTPBP1 -0.78 -12.08 -0.55 4.15e-28 Menopause (age at onset); LUSC cis rs7605827 0.930 rs12692267 chr2:15572834 A/G cg19274914 chr2:15703543 NA -0.5 -9.69 -0.47 1.01e-19 Educational attainment (years of education); LUSC cis rs61931739 0.500 rs12371415 chr12:34521362 C/T cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.71e-10 Morning vs. evening chronotype; LUSC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg15468180 chr1:107600409 PRMT6 -0.38 -6.08 -0.32 3.28e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs55871839 0.640 rs4738734 chr8:59814330 A/T cg07426533 chr8:59803705 TOX -0.37 -6.08 -0.32 3.27e-9 Pneumonia; LUSC cis rs8072100 0.811 rs9889709 chr17:45445229 C/T cg08085267 chr17:45401833 C17orf57 -0.55 -8.55 -0.42 4.52e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs244293 1.000 rs2628313 chr17:53235352 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.43 -6.11 -0.32 2.74e-9 Menarche (age at onset); LUSC cis rs4077515 0.874 rs4498662 chr9:139290251 C/G cg14169450 chr9:139327907 INPP5E 0.42 7.68 0.39 1.78e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6920965 0.563 rs1544292 chr6:126175093 G/C cg05901451 chr6:126070800 HEY2 -0.39 -5.66 -0.3 3.26e-8 High light scatter reticulocyte count; LUSC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg12292205 chr6:26970375 C6orf41 0.68 11.99 0.55 8.26e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC trans rs8002861 0.840 rs7989353 chr13:44438957 T/C cg12856521 chr11:46389249 DGKZ 0.42 6.69 0.34 9.38e-11 Leprosy; LUSC cis rs2806561 0.765 rs679591 chr1:23499916 T/C cg12483005 chr1:23474871 LUZP1 0.41 6.15 0.32 2.18e-9 Height; LUSC cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg00071950 chr4:10020882 SLC2A9 0.66 11.27 0.52 3.52e-25 Bone mineral density; LUSC cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg05472934 chr7:22766657 IL6 0.47 7.63 0.39 2.4e-13 Lung cancer; LUSC trans rs3733585 0.588 rs6449154 chr4:9956404 C/T cg26043149 chr18:55253948 FECH -0.45 -7.02 -0.36 1.23e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs72792513 1.000 rs3860475 chr2:22912603 C/A cg05844895 chr16:88969569 CBFA2T3 0.52 6.1 0.32 2.9e-9 Hepatitis B; LUSC cis rs9653442 0.564 rs13013594 chr2:100784190 A/G cg07810366 chr2:100720526 AFF3 -0.44 -7.49 -0.38 6.12e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs11039798 0.582 rs60764175 chr11:48775856 T/G cg15704280 chr7:45808275 SEPT13 0.73 8.25 0.41 3.75e-15 Axial length; LUSC cis rs9479482 0.935 rs5017315 chr6:150333574 C/T cg07578070 chr6:150326732 RAET1K 0.41 6.4 0.33 5.14e-10 Alopecia areata; LUSC trans rs11039798 0.660 rs717897 chr11:48375604 A/G cg15704280 chr7:45808275 SEPT13 -0.66 -7.12 -0.36 6.85e-12 Axial length; LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg24675658 chr1:53192096 ZYG11B 0.6 9.54 0.46 3.17e-19 Monocyte count; LUSC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg16386425 chr10:429943 DIP2C 0.41 6.46 0.33 3.78e-10 Psychosis in Alzheimer's disease; LUSC cis rs7903847 0.646 rs10882924 chr10:99159304 T/A cg08345082 chr10:99160200 RRP12 -0.35 -7.11 -0.36 7.29e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs11098499 0.863 rs10013305 chr4:120450424 G/A cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs3812831 0.629 rs7318527 chr13:114946956 C/T cg15896084 chr13:114927664 NA 0.41 7.5 0.38 5.81e-13 Schizophrenia; LUSC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.14 0.45 6.43e-18 Height; LUSC cis rs4930103 0.935 rs2075745 chr11:2018336 A/T cg23202291 chr11:1979235 NA 0.4 6.15 0.32 2.19e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs9287719 0.967 rs7592691 chr2:10737426 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg15556689 chr8:8085844 FLJ10661 -0.65 -9.97 -0.48 1.12e-20 Mean corpuscular volume; LUSC trans rs1941687 0.765 rs11877423 chr18:31390368 G/A cg27147174 chr7:100797783 AP1S1 -0.45 -6.56 -0.34 2.04e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs9291683 0.530 rs998675 chr4:9948829 A/G cg26043149 chr18:55253948 FECH 0.45 6.78 0.35 5.46e-11 Bone mineral density; LUSC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.44 -0.38 8.52e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.79 0.65 2.33e-42 Bladder cancer; LUSC cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg24596788 chr1:163392923 NA -0.45 -7.58 -0.38 3.37e-13 Motion sickness; LUSC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg13531842 chr10:38383804 ZNF37A -0.46 -7.19 -0.37 4.35e-12 Extrinsic epigenetic age acceleration; LUSC trans rs8073060 0.586 rs117573546 chr17:33909588 G/A cg19694781 chr19:47549865 TMEM160 1.15 18.32 0.71 2.27e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs6121246 0.567 rs7266471 chr20:30220599 T/A cg21427119 chr20:30132790 HM13 -0.44 -6.18 -0.32 1.83e-9 Mean corpuscular hemoglobin; LUSC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg25174290 chr11:3078921 CARS 0.6 9.36 0.46 1.19e-18 Longevity; LUSC cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg11244672 chr19:19639970 YJEFN3 -0.55 -6.84 -0.35 3.86e-11 Bipolar disorder; LUSC cis rs3858704 0.517 rs7297186 chr12:111778178 C/T cg10833066 chr12:111807467 FAM109A -0.64 -13.27 -0.59 1.39e-32 Idiopathic osteonecrosis of the femoral head; LUSC trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg03929089 chr4:120376271 NA 0.59 6.51 0.34 2.77e-10 Axial length; LUSC cis rs9660992 0.573 rs12144980 chr1:205185104 C/T cg21643547 chr1:205240462 TMCC2 -0.49 -9.28 -0.45 2.22e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6700896 0.897 rs11208701 chr1:66134698 C/T cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9868809 0.505 rs11719291 chr3:48735706 A/G cg07636037 chr3:49044803 WDR6 -0.67 -5.77 -0.3 1.79e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs4718428 1.000 rs1830070 chr7:66349671 T/C cg18876405 chr7:65276391 NA 0.49 7.62 0.38 2.72e-13 Corneal structure; LUSC cis rs2717559 0.542 rs11777634 chr8:143887957 C/T cg17252645 chr8:143867129 LY6D -0.55 -10.37 -0.49 4.92e-22 Urinary tract infection frequency; LUSC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg06618935 chr21:46677482 NA -0.37 -7.33 -0.37 1.75e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg22868518 chr11:507468 RNH1 -0.63 -5.96 -0.31 6.47e-9 Body mass index; LUSC cis rs738322 1.000 rs133012 chr22:38570721 G/A cg25457927 chr22:38595422 NA -0.41 -8.8 -0.43 7.72e-17 Cutaneous nevi; LUSC cis rs7923452 0.938 rs67812762 chr10:30759479 G/T cg25182066 chr10:30743637 MAP3K8 0.58 6.8 0.35 4.9e-11 Itch intensity from mosquito bite; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25858983 chr17:42295711 UBTF 0.43 6.85 0.35 3.56e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3849570 0.961 rs10154945 chr3:81833766 A/C cg07356753 chr3:81810745 GBE1 -0.68 -11.09 -0.52 1.46e-24 Waist circumference;Body mass index; LUSC cis rs3008870 1.000 rs3008853 chr1:67385488 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.14 0.64 8.56e-40 Lymphocyte percentage of white cells; LUSC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg24209194 chr3:40518798 ZNF619 0.47 6.52 0.34 2.55e-10 Renal cell carcinoma; LUSC cis rs68170813 0.523 rs75999022 chr7:107017135 C/T cg02696742 chr7:106810147 HBP1 -0.64 -9.61 -0.47 1.82e-19 Coronary artery disease; LUSC cis rs4077515 0.839 rs3812563 chr9:139271106 A/G cg14019695 chr9:139328340 INPP5E 0.43 8.1 0.41 1.06e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10761482 0.954 rs10443926 chr10:62065993 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.43 -0.33 4.41e-10 Schizophrenia; LUSC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.16 0.32 2.14e-9 Menopause (age at onset); LUSC cis rs7215564 0.818 rs35929483 chr17:78635944 C/A cg23238734 chr17:78661607 RPTOR 0.49 6.2 0.32 1.66e-9 Myopia (pathological); LUSC cis rs11030122 0.632 rs11030599 chr11:4031677 A/G cg08557956 chr11:4115526 RRM1 -0.46 -5.88 -0.31 1e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg00071950 chr4:10020882 SLC2A9 -0.54 -7.4 -0.38 1.09e-12 Bone mineral density; LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg01879757 chr17:41196368 BRCA1 -0.46 -7.13 -0.36 6.39e-12 Menopause (age at onset); LUSC cis rs9916302 0.706 rs903507 chr17:37726423 A/G cg07936489 chr17:37558343 FBXL20 -0.8 -10.18 -0.49 2.3e-21 Glomerular filtration rate (creatinine); LUSC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg08493051 chr2:3487164 NA -0.56 -8.81 -0.43 6.76e-17 Neurofibrillary tangles; LUSC cis rs1941023 0.503 rs4939348 chr11:60135871 A/C cg08716584 chr11:60157161 MS4A7 -0.62 -11.74 -0.54 6.8e-27 Congenital heart disease (maternal effect); LUSC cis rs394563 0.559 rs13219868 chr6:149686518 T/G cg11245181 chr6:149772854 ZC3H12D 0.3 6.38 0.33 6.07e-10 Dupuytren's disease; LUSC cis rs2242663 0.798 rs607736 chr11:66328877 G/A cg18002602 chr11:66138449 SLC29A2 -0.36 -6.31 -0.33 8.82e-10 Bipolar disorder; LUSC cis rs7937682 0.924 rs513425 chr11:111504861 C/T cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.13 0.48 3.32e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs12541635 0.966 rs7819327 chr8:106986003 A/C cg10147462 chr8:107024639 NA 0.56 9.74 0.47 6.89e-20 Age of smoking initiation; LUSC cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.99 0.55 8.55e-28 Chronic sinus infection; LUSC cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg00745463 chr17:30367425 LRRC37B -0.84 -9.91 -0.48 1.85e-20 Hip circumference adjusted for BMI; LUSC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg06145435 chr7:1022769 CYP2W1 0.34 5.75 0.3 1.98e-8 Bronchopulmonary dysplasia; LUSC cis rs10740039 0.883 rs1975442 chr10:62410919 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.85 -0.35 3.61e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2067615 0.542 rs10861654 chr12:107122896 A/G cg15890332 chr12:107067104 RFX4 0.34 6.15 0.32 2.22e-9 Heart rate; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg22184145 chr4:57845401 POLR2B 0.4 6.17 0.32 1.97e-9 Triglycerides; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10446143 chr21:44394730 PKNOX1 0.41 6.17 0.32 2e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs6964587 1.000 rs13245393 chr7:91641928 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.6e-8 Breast cancer; LUSC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg25072359 chr17:41440525 NA -0.62 -9.19 -0.45 4.43e-18 Menopause (age at onset); LUSC cis rs11148252 0.840 rs3886077 chr13:52949053 C/A cg00495681 chr13:53174319 NA 0.53 8.91 0.44 3.33e-17 Lewy body disease; LUSC trans rs1493916 0.748 rs2040203 chr18:31307420 G/T cg27147174 chr7:100797783 AP1S1 -0.55 -8.58 -0.42 3.57e-16 Life satisfaction; LUSC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg05535760 chr7:792225 HEATR2 -0.73 -7.52 -0.38 5.18e-13 Cerebrospinal P-tau181p levels; LUSC cis rs3744061 0.505 rs9907915 chr17:74651236 A/G cg27546012 chr17:74684504 MXRA7 -0.4 -6.88 -0.35 2.93e-11 Retinal arteriolar caliber; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg13886124 chr9:130186480 ZNF79 0.45 6.12 0.32 2.67e-9 Neuroticism; LUSC cis rs12220238 1.000 rs11000890 chr10:75904073 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.05 0.36 1.05e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs11039100 0.850 rs11039118 chr11:5832601 A/G cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.23 0.41 4.11e-15 Axial length; LUSC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg17385448 chr1:15911702 AGMAT 0.37 6.37 0.33 6.3e-10 Systolic blood pressure; LUSC cis rs6545883 0.929 rs2593635 chr2:61634706 A/C cg15711740 chr2:61764176 XPO1 0.44 6.64 0.34 1.26e-10 Tuberculosis; LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.13 0.41 8.5e-15 Prudent dietary pattern; LUSC trans rs2221154 0.648 rs7620147 chr3:28959712 C/T cg16413675 chr16:2520055 NTN3 0.29 6.12 0.32 2.63e-9 Alzheimer's disease; LUSC cis rs7465272 0.500 rs7463655 chr8:143731034 G/C cg24634471 chr8:143751801 JRK 0.51 7.25 0.37 2.97e-12 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg08859206 chr1:53392774 SCP2 -0.68 -12.93 -0.58 2.87e-31 Monocyte count; LUSC cis rs2070433 0.799 rs7279002 chr21:47910523 C/T cg12379764 chr21:47803548 PCNT -0.69 -9.41 -0.46 8.01e-19 Lymphocyte counts; LUSC cis rs9527 0.545 rs12784384 chr10:104957594 G/C cg05855489 chr10:104503620 C10orf26 0.51 7.9 0.4 3.95e-14 Arsenic metabolism; LUSC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg12564285 chr5:131593104 PDLIM4 0.35 6.31 0.33 8.93e-10 Breast cancer;Mosquito bite size; LUSC cis rs9905704 0.647 rs10221208 chr17:57047885 T/C cg05425664 chr17:57184151 TRIM37 -0.51 -7.63 -0.39 2.46e-13 Testicular germ cell tumor; LUSC cis rs1008375 0.835 rs9760627 chr4:17651508 C/T cg16339924 chr4:17578868 LAP3 0.57 8.72 0.43 1.38e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7712401 0.601 rs62377430 chr5:122334688 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.22 -0.45 3.4e-18 Mean platelet volume; LUSC cis rs10751667 0.961 rs7480178 chr11:927108 T/C cg01483505 chr11:975446 AP2A2 0.41 5.66 0.3 3.29e-8 Alzheimer's disease (late onset); LUSC cis rs6076065 0.644 rs2424535 chr20:23381196 T/C cg11657817 chr20:23433608 CST11 0.41 7.81 0.39 7.57e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg04546413 chr19:29218101 NA 0.71 11.96 0.55 1.14e-27 Methadone dose in opioid dependence; LUSC cis rs9653442 1.000 rs9653442 chr2:100825367 A/G cg07810366 chr2:100720526 AFF3 0.43 7.6 0.38 3.04e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7917772 0.636 rs7079231 chr10:104527341 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.66 0.39 2.03e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9837602 0.938 rs9814359 chr3:99797013 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.32 0.33 8.18e-10 Breast cancer; LUSC cis rs7786808 0.653 rs7810861 chr7:158212633 G/A cg01191920 chr7:158217561 PTPRN2 -0.49 -10.29 -0.49 9.55e-22 Obesity-related traits; LUSC trans rs7824557 0.591 rs2572452 chr8:11228254 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.43 -0.33 4.38e-10 Retinal vascular caliber; LUSC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.03 15.77 0.65 2.97e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg18904891 chr8:8559673 CLDN23 0.56 7.63 0.39 2.53e-13 Obesity-related traits; LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg10729496 chr3:10149963 C3orf24 0.56 7.25 0.37 2.92e-12 Alzheimer's disease; LUSC cis rs34779708 0.897 rs9787566 chr10:35279455 T/A cg03585969 chr10:35415529 CREM 0.65 9.25 0.45 2.78e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg18099408 chr3:52552593 STAB1 -0.41 -7.15 -0.36 5.65e-12 Bipolar disorder; LUSC cis rs10782582 0.593 rs11163915 chr1:76130199 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.2 -0.37 4e-12 Daytime sleep phenotypes; LUSC cis rs7617773 0.817 rs936427 chr3:48301074 A/G cg20734569 chr3:48348370 SPINK8 0.46 8.08 0.4 1.16e-14 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19998654 chr2:37458983 CEBPZ;C2orf56 -0.47 -6.35 -0.33 7.09e-10 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26361928 chr5:151151522 G3BP1 0.47 6.45 0.33 4.04e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg08067268 chr2:26466485 HADHB;HADHA -0.52 -7.47 -0.38 6.96e-13 Gut microbiome composition (summer); LUSC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs8060686 0.641 rs12445396 chr16:68155121 G/A cg09835421 chr16:68378352 PRMT7 -0.56 -6.13 -0.32 2.43e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4919687 0.679 rs12762176 chr10:104499232 A/T cg04362960 chr10:104952993 NT5C2 0.51 7.14 0.36 5.71e-12 Colorectal cancer; LUSC cis rs672059 0.966 rs689375 chr1:183160973 A/G ch.1.3577855R chr1:183094577 LAMC1 0.55 8.06 0.4 1.37e-14 Hypertriglyceridemia; LUSC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.36 -0.33 6.78e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg12219531 chr12:120966889 COQ5 0.6 8.08 0.4 1.2e-14 High light scatter reticulocyte count; LUSC cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2228479 0.850 rs76075456 chr16:89834270 T/C cg24644049 chr4:85504048 CDS1 0.87 7.49 0.38 6.2e-13 Skin colour saturation; LUSC cis rs6539267 0.885 rs12579099 chr12:106765727 A/G cg00173435 chr12:106696525 TCP11L2 0.46 6.49 0.33 3.06e-10 Tourette syndrome; LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg22920501 chr2:26401640 FAM59B 0.82 12.36 0.56 3.58e-29 Gut microbiome composition (summer); LUSC cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.26 0.37 2.72e-12 Motion sickness; LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg08132940 chr7:1081526 C7orf50 -0.52 -6.15 -0.32 2.27e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg16325326 chr1:53192061 ZYG11B 0.97 20.79 0.75 3.46e-62 Monocyte count; LUSC cis rs6969780 0.915 rs17471520 chr7:27178790 T/C cg26364809 chr7:27145159 NA -0.57 -5.8 -0.3 1.52e-8 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs7267979 1.000 rs2259873 chr20:25280781 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg16386425 chr10:429943 DIP2C 0.37 5.68 0.3 2.98e-8 Psychosis in Alzheimer's disease; LUSC cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC trans rs7937682 0.855 rs539553 chr11:111477333 C/T cg18187862 chr3:45730750 SACM1L 0.52 6.83 0.35 4e-11 Primary sclerosing cholangitis; LUSC cis rs8135665 0.625 rs8142185 chr22:38451080 A/C cg13116946 chr22:38479732 SLC16A8 0.41 6.44 0.33 4.26e-10 Advanced age-related macular degeneration;Age-related macular degeneration; LUSC cis rs8058578 1.000 rs67128646 chr16:30672097 A/C cg05768032 chr16:30646687 NA 0.4 5.81 0.3 1.48e-8 Multiple myeloma; LUSC cis rs9388451 0.513 rs1268069 chr6:126039994 A/C cg05901451 chr6:126070800 HEY2 -0.76 -12.67 -0.57 2.54e-30 Brugada syndrome; LUSC cis rs9517320 0.534 rs61971163 chr13:99188883 G/A cg07423050 chr13:99094983 FARP1 -0.55 -10.05 -0.48 5.96e-21 Longevity; LUSC cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg06627628 chr2:24431161 ITSN2 -0.59 -7.24 -0.37 3.06e-12 Lymphocyte counts; LUSC cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg08508325 chr11:3079039 CARS -0.51 -12.69 -0.57 2.16e-30 Longevity; LUSC cis rs7542375 0.930 rs7523735 chr1:221064780 C/G cg16008148 chr1:221062819 NA 0.37 6.61 0.34 1.49e-10 Obesity-related traits; LUSC cis rs6840360 0.571 rs875667 chr4:152525477 G/A cg22705602 chr4:152727874 NA -0.32 -6.42 -0.33 4.59e-10 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.31 0.53 2.45e-25 Menopause (age at onset); LUSC cis rs11155671 0.530 rs7756850 chr6:150212596 G/C cg09699651 chr6:150184138 LRP11 0.45 7.12 0.36 6.69e-12 Testicular germ cell tumor; LUSC cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg03060546 chr3:49711283 APEH -0.7 -10.08 -0.48 4.89e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9287719 0.839 rs12692415 chr2:10745474 A/G cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs7647973 0.731 rs7617480 chr3:49210732 G/T cg07636037 chr3:49044803 WDR6 -0.61 -7.81 -0.39 7.65e-14 Menarche (age at onset); LUSC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg08045932 chr20:61659980 NA 0.59 10.51 0.5 1.65e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs6582630 0.503 rs4882293 chr12:38388200 G/C cg13010199 chr12:38710504 ALG10B -0.44 -6.58 -0.34 1.82e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7833790 0.750 rs10108955 chr8:82690644 C/T cg02079420 chr8:82753780 SNX16 0.4 6.12 0.32 2.62e-9 Diastolic blood pressure; LUSC cis rs61931739 0.500 rs9669027 chr12:34583528 C/T cg06521331 chr12:34319734 NA 0.41 6.75 0.35 6.66e-11 Morning vs. evening chronotype; LUSC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg08677398 chr8:58056175 NA 0.41 5.71 0.3 2.51e-8 Developmental language disorder (linguistic errors); LUSC cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg01579765 chr21:45077557 HSF2BP -0.51 -10.95 -0.51 4.95e-24 Mean corpuscular volume; LUSC cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg05347473 chr6:146136440 FBXO30 0.54 9.34 0.46 1.39e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.46 -7.48 -0.38 6.61e-13 IgG glycosylation; LUSC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg10053473 chr17:62856997 LRRC37A3 0.67 10.63 0.5 6.51e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs6076960 0.682 rs6054065 chr20:6267920 G/A cg17788362 chr6:86352627 SYNCRIP 0.48 7.34 0.37 1.61e-12 Smooth-surface caries; LUSC cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.56 9.53 0.46 3.4e-19 IgG glycosylation; LUSC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.96 -0.31 6.47e-9 Alzheimer's disease (late onset); LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.07 0.32 3.48e-9 Lymphocyte counts; LUSC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs6570726 0.905 rs1355146 chr6:145781741 A/C cg23711669 chr6:146136114 FBXO30 -0.7 -12.1 -0.55 3.5e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs9325144 0.534 rs6582538 chr12:38629997 A/C cg13010199 chr12:38710504 ALG10B -0.54 -8.24 -0.41 4.07e-15 Morning vs. evening chronotype; LUSC cis rs6906287 0.647 rs2213857 chr6:118806780 A/G cg21191810 chr6:118973309 C6orf204 0.33 5.9 0.31 8.9e-9 Electrocardiographic conduction measures; LUSC trans rs1997103 1.000 rs6958664 chr7:55404958 T/G cg20935933 chr6:143382018 AIG1 0.5 7.27 0.37 2.61e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg07679203 chr4:1993400 WHSC2 -0.38 -6.25 -0.32 1.28e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.52 5.95 0.31 6.75e-9 Schizophrenia; LUSC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg16414030 chr3:133502952 NA 0.44 6.71 0.34 8.42e-11 Iron status biomarkers; LUSC cis rs9400467 0.528 rs11153288 chr6:111715238 T/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.36 2e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.54 -9.35 -0.46 1.31e-18 Menopause (age at onset); LUSC cis rs9807989 0.729 rs10170583 chr2:102974764 G/A cg03938978 chr2:103052716 IL18RAP 0.31 5.7 0.3 2.63e-8 Asthma; LUSC cis rs9527 0.590 rs7897663 chr10:104905604 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs7945705 0.806 rs12224436 chr11:8815825 C/A cg21881798 chr11:8931708 C11orf17;ST5 0.56 10.87 0.51 8.98e-24 Hemoglobin concentration; LUSC cis rs10911363 0.592 rs12117885 chr1:183494214 C/T cg09173681 chr1:183549694 NCF2 -0.62 -11.03 -0.52 2.51e-24 Systemic lupus erythematosus; LUSC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg05754148 chr16:3507555 NAT15 -0.83 -9.01 -0.44 1.59e-17 Tuberculosis; LUSC cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg16586182 chr3:47516702 SCAP 0.53 8.33 0.41 2.05e-15 Colorectal cancer; LUSC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg17724175 chr1:150552817 MCL1 0.37 6.74 0.35 7.06e-11 Tonsillectomy; LUSC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.02 0.48 7.73e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3749237 0.964 rs1799843 chr3:49849723 G/A cg05072774 chr3:49840536 C3orf54 -0.43 -5.96 -0.31 6.27e-9 Resting heart rate; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg06145435 chr7:1022769 CYP2W1 0.31 6.34 0.33 7.49e-10 Longevity;Endometriosis; LUSC cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg06671706 chr8:8559999 CLDN23 0.49 6.57 0.34 1.94e-10 Obesity-related traits; LUSC cis rs8040855 0.579 rs6496797 chr15:85726855 T/C cg04831495 chr15:85060580 GOLGA6L5 0.42 6.94 0.35 2.08e-11 Bulimia nervosa; LUSC cis rs7824557 0.767 rs6985460 chr8:11171087 A/C cg27411982 chr8:10470053 RP1L1 0.39 5.98 0.31 5.7e-9 Retinal vascular caliber; LUSC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC cis rs10896135 0.554 rs3741364 chr11:66451178 C/T cg24851651 chr11:66362959 CCS 0.49 6.66 0.34 1.1e-10 Bipolar disorder; LUSC cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg07636037 chr3:49044803 WDR6 -0.7 -9.71 -0.47 8.23e-20 Menarche (age at onset); LUSC cis rs367943 0.712 rs6896650 chr5:112681048 T/C cg12552261 chr5:112820674 MCC 0.37 6.12 0.32 2.62e-9 Type 2 diabetes; LUSC cis rs2540226 0.844 rs12620957 chr2:40006430 A/C cg23576258 chr2:39999331 THUMPD2 0.35 5.93 0.31 7.46e-9 Personality dimensions; LUSC cis rs3020736 0.500 rs2413672 chr22:42513261 C/T cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs12738007 0.544 rs12408688 chr1:29431072 C/T cg01925633 chr1:29338769 EPB41 0.39 6.01 0.31 4.79e-9 Schizophrenia; LUSC cis rs308403 0.532 rs309386 chr4:123665991 C/G cg10495464 chr4:123653540 BBS12;LOC729338 0.98 18.61 0.71 1.54e-53 Blood protein levels; LUSC cis rs7191439 0.728 rs4238687 chr16:88788903 T/G cg27087555 chr16:88793112 FAM38A -1.39 -15.52 -0.65 2.77e-41 Plateletcrit; LUSC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg14343924 chr8:8086146 FLJ10661 0.45 6.31 0.33 8.99e-10 Systolic blood pressure; LUSC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.36 -6.18 -0.32 1.92e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9329221 0.527 rs10903328 chr8:10332167 G/C cg27411982 chr8:10470053 RP1L1 0.46 6.99 0.36 1.46e-11 Neuroticism; LUSC trans rs1325195 0.920 rs377785 chr1:179224067 T/A cg11624085 chr17:8464688 MYH10 0.41 6.72 0.35 7.76e-11 IgE grass sensitization; LUSC cis rs2688608 1.000 rs2688610 chr10:75654931 A/G cg23231163 chr10:75533350 FUT11 0.39 6.6 0.34 1.61e-10 Inflammatory bowel disease; LUSC cis rs9914988 0.943 rs9893782 chr17:27108132 C/T cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7241530 0.610 rs7230650 chr18:75892679 A/G cg14642773 chr18:75888474 NA 0.37 5.65 0.3 3.53e-8 Educational attainment (years of education); LUSC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg09021430 chr5:549028 NA -0.55 -7.25 -0.37 2.95e-12 Lung disease severity in cystic fibrosis; LUSC cis rs10207060 0.500 rs7566489 chr2:240703985 C/T cg07506560 chr2:240697449 NA 0.44 6.87 0.35 3.12e-11 Obesity-related traits; LUSC cis rs6977660 0.714 rs12537283 chr7:19817658 G/T cg05791153 chr7:19748676 TWISTNB 0.67 7.09 0.36 8.17e-12 Thyroid stimulating hormone; LUSC cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.22 0.88 3.18e-111 Chronic sinus infection; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg02018176 chr4:1364513 KIAA1530 0.48 8.4 0.42 1.28e-15 Obesity-related traits; LUSC cis rs41271951 0.512 rs116666233 chr1:151056058 C/T cg11822372 chr1:151115635 SEMA6C -0.78 -7.18 -0.37 4.51e-12 Blood protein levels; LUSC cis rs68170813 0.559 rs113211438 chr7:106969198 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.57 -0.46 2.53e-19 Coronary artery disease; LUSC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg26408565 chr15:76604113 ETFA -0.5 -7.98 -0.4 2.4e-14 Blood metabolite levels; LUSC cis rs2404602 0.669 rs9788684 chr15:77194838 A/T cg26408565 chr15:76604113 ETFA -0.48 -7.58 -0.38 3.51e-13 Blood metabolite levels; LUSC cis rs12310956 0.532 rs7955514 chr12:33978737 G/A cg06521331 chr12:34319734 NA -0.46 -7.32 -0.37 1.82e-12 Morning vs. evening chronotype; LUSC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg16447950 chr5:562315 NA -0.54 -6.84 -0.35 3.69e-11 Obesity-related traits; LUSC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg11859384 chr17:80120422 CCDC57 0.36 5.68 0.3 2.86e-8 Life satisfaction; LUSC cis rs4961252 0.505 rs4961327 chr8:142102053 C/T cg09914555 chr8:142094789 NA -0.48 -7.1 -0.36 7.74e-12 Isovolumetric relaxation time;Response to interferon beta therapy; LUSC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg09455208 chr3:40491958 NA 0.58 10.46 0.5 2.38e-22 Renal cell carcinoma; LUSC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.42 0.33 4.68e-10 Cerebrospinal P-tau181p levels; LUSC cis rs56804039 1.000 rs17616779 chr8:8382374 A/G cg06636001 chr8:8085503 FLJ10661 0.54 6.92 0.35 2.25e-11 Cervical cancer; LUSC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11794814 chr19:40791331 AKT2 0.46 6.18 0.32 1.9e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs597583 0.715 rs4938400 chr11:117399604 C/A cg27161313 chr11:117392002 DSCAML1 -0.51 -8.02 -0.4 1.81e-14 Putamen volume; LUSC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg04166393 chr7:2884313 GNA12 0.42 5.86 0.31 1.09e-8 Height; LUSC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg26408565 chr15:76604113 ETFA -0.48 -7.69 -0.39 1.67e-13 Blood metabolite levels; LUSC cis rs9814567 1.000 rs9814567 chr3:134218557 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 13.82 0.6 1.13e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10740039 0.883 rs1837946 chr10:62393434 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs561341 0.609 rs4795659 chr17:30187139 C/G cg13647721 chr17:30228624 UTP6 -0.69 -7.5 -0.38 5.71e-13 Hip circumference adjusted for BMI; LUSC cis rs17270561 0.609 rs3922842 chr6:25736564 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.92 13.28 0.59 1.37e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs367615 0.704 rs7705399 chr5:108850351 G/C cg17395555 chr5:108820864 NA 0.58 10.67 0.5 4.63e-23 Colorectal cancer (SNP x SNP interaction); LUSC cis rs2439831 0.681 rs11858152 chr15:43634196 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.78 0.51 1.85e-23 Lung cancer in ever smokers; LUSC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -7.3 -0.37 2.11e-12 Developmental language disorder (linguistic errors); LUSC cis rs7819412 0.715 rs2409727 chr8:11043236 C/T cg21775007 chr8:11205619 TDH -0.5 -6.95 -0.36 1.9e-11 Triglycerides; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.55 -8.42 -0.42 1.12e-15 Lymphocyte counts; LUSC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg11062466 chr8:58055876 NA 0.69 8.13 0.41 8.64e-15 Developmental language disorder (linguistic errors); LUSC cis rs7589342 0.628 rs10496403 chr2:106419622 T/G cg14210321 chr2:106509881 NCK2 -0.45 -5.78 -0.3 1.75e-8 Addiction; LUSC trans rs12165098 0.636 rs4511605 chr18:36744974 T/C cg23858286 chr9:138135095 NA -0.42 -6.07 -0.32 3.44e-9 Sleep duration; LUSC cis rs13082711 0.911 rs66694067 chr3:27477337 C/T cg02860705 chr3:27208620 NA 0.5 7.99 0.4 2.25e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs11048434 0.626 rs1805736 chr12:9084931 A/G cg13575925 chr12:9217583 LOC144571 -0.32 -5.92 -0.31 7.91e-9 Sjögren's syndrome; LUSC cis rs4478858 0.735 rs10798842 chr1:31778648 A/G cg00250761 chr1:31883323 NA -0.35 -8.54 -0.42 4.8e-16 Alcohol dependence; LUSC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg24733560 chr20:60626293 TAF4 0.35 5.68 0.3 2.91e-8 Body mass index; LUSC trans rs2786098 0.656 rs10922262 chr1:197559835 G/A cg16005942 chr6:160526640 IGF2R 0.5 6.04 0.31 4.16e-9 Asthma; LUSC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg18350739 chr11:68623251 NA -0.4 -6.98 -0.36 1.57e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11098499 0.954 rs9998585 chr4:120396802 T/A cg24375607 chr4:120327624 NA 0.81 12.25 0.56 9.55e-29 Corneal astigmatism; LUSC cis rs9660992 0.624 rs72745217 chr1:205261482 C/G cg00857998 chr1:205179979 DSTYK 0.62 9.52 0.46 3.48e-19 Mean corpuscular volume;Mean platelet volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07981845 chr10:104154074 NFKB2 -0.4 -6.01 -0.31 4.86e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2637266 0.600 rs2395430 chr10:78465471 G/A cg18941641 chr10:78392320 NA 0.33 5.93 0.31 7.61e-9 Pulmonary function; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22296620 chr15:45315419 SORD -0.43 -6.09 -0.32 3.03e-9 Electrocardiographic conduction measures; LUSC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.46 -0.33 3.71e-10 Menopause (age at onset); LUSC cis rs7408868 1.000 rs10420466 chr19:15261371 G/T cg14696996 chr19:15285081 NOTCH3 0.98 8.93 0.44 3.01e-17 Pulse pressure; LUSC cis rs7584330 0.955 rs58643200 chr2:238389855 A/G cg16989719 chr2:238392110 NA -0.42 -7.19 -0.37 4.35e-12 Prostate cancer; LUSC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg18827107 chr12:86230957 RASSF9 0.45 6.93 0.35 2.18e-11 Major depressive disorder; LUSC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg18827107 chr12:86230957 RASSF9 0.46 7.06 0.36 9.54e-12 Major depressive disorder; LUSC cis rs34779708 0.966 rs4934538 chr10:35472150 T/C cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.65e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14240646 chr10:27532245 ACBD5 -0.66 -7.91 -0.4 3.77e-14 Breast cancer; LUSC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.08 0.32 3.27e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7712401 0.818 rs13166350 chr5:122153569 C/T cg19077854 chr5:122220652 SNX24 0.35 8.08 0.4 1.19e-14 Mean platelet volume; LUSC cis rs561341 1.000 rs68140514 chr17:30335781 T/C cg00745463 chr17:30367425 LRRC37B -0.76 -9.31 -0.45 1.74e-18 Hip circumference adjusted for BMI; LUSC cis rs7760949 0.963 rs9349840 chr6:13903809 G/A cg27413430 chr6:13925136 RNF182 0.5 7.46 0.38 7.54e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs7592578 0.679 rs4287794 chr2:191327147 T/C cg10560079 chr2:191398806 TMEM194B -0.65 -8.14 -0.41 8.06e-15 Diastolic blood pressure; LUSC cis rs116988415 0.539 rs17180350 chr14:65249066 C/T cg25083366 chr14:65239357 SPTB 0.62 6.65 0.34 1.21e-10 Daytime sleep phenotypes; LUSC trans rs1728785 1.000 rs7196104 chr16:68579746 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg21433313 chr16:3507492 NAT15 -0.38 -5.99 -0.31 5.43e-9 Body mass index (adult); LUSC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg03161606 chr19:29218774 NA 0.61 9.03 0.44 1.38e-17 Methadone dose in opioid dependence; LUSC cis rs709400 0.658 rs72708874 chr14:103899251 T/G cg24130564 chr14:104152367 KLC1 -0.46 -6.34 -0.33 7.27e-10 Body mass index; LUSC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg21699342 chr2:239360505 ASB1 0.58 10.78 0.51 1.95e-23 Multiple system atrophy; LUSC cis rs8077577 0.789 rs11078411 chr17:18088094 C/T cg16794390 chr17:18148240 FLII 0.4 5.68 0.3 2.96e-8 Obesity-related traits; LUSC cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.07 0.55 4.28e-28 Colorectal cancer; LUSC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg25767906 chr1:53392781 SCP2 -0.38 -6.44 -0.33 4.17e-10 Monocyte count; LUSC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.98 0.36 1.57e-11 Intelligence (multi-trait analysis); LUSC trans rs800082 0.690 rs6440260 chr3:144289214 C/A cg24215973 chr2:240111563 HDAC4 -0.61 -9.75 -0.47 6.38e-20 Smoking behavior; LUSC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg06671706 chr8:8559999 CLDN23 0.48 6.52 0.34 2.67e-10 Obesity-related traits; LUSC cis rs6541297 0.645 rs4846919 chr1:230301451 A/G cg20703242 chr1:230279135 GALNT2 0.48 5.72 0.3 2.31e-8 Coronary artery disease; LUSC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg17509989 chr5:176798049 RGS14 0.7 11.32 0.53 2.23e-25 Hemoglobin concentration;Hematocrit; LUSC cis rs7577696 0.752 rs12614686 chr2:32363171 A/G cg02381751 chr2:32503542 YIPF4 -0.44 -6.22 -0.32 1.53e-9 Inflammatory biomarkers; LUSC cis rs7215564 0.730 rs4889877 chr17:78662459 A/C cg09596252 chr17:78655493 RPTOR 0.54 5.86 0.31 1.13e-8 Myopia (pathological); LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg11965913 chr1:205819406 PM20D1 1.05 27.5 0.83 7.93e-88 Menarche (age at onset); LUSC trans rs17039065 1.000 rs72889364 chr4:109383977 C/T cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.24e-10 Gut microbiome composition (summer); LUSC trans rs1422110 0.543 rs768240 chr5:85420954 C/T cg01787110 chr1:109008453 NBPF6 -0.5 -9.21 -0.45 3.65e-18 Attention function in attention deficit hyperactive disorder; LUSC cis rs965469 1.000 rs2281497 chr20:3258874 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -6.01 -0.31 4.98e-9 IFN-related cytopenia; LUSC cis rs10744422 1.000 rs3852537 chr12:123361501 T/C cg25930673 chr12:123319894 HIP1R -0.63 -6.21 -0.32 1.6e-9 Schizophrenia; LUSC cis rs59698941 0.943 rs59634464 chr5:132178735 A/G cg02081065 chr5:132209139 LEAP2 -0.62 -6.02 -0.31 4.62e-9 Apolipoprotein A-IV levels; LUSC cis rs7524258 0.900 rs6577426 chr1:7306451 A/G cg07173049 chr1:7289937 CAMTA1 0.32 6.59 0.34 1.74e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs3790645 1.000 rs35245195 chr1:26884039 C/G cg17456097 chr1:26900765 RPS6KA1 0.43 6.15 0.32 2.21e-9 Glucose homeostasis traits; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg18000306 chr6:288505 NA 0.33 6.33 0.33 7.73e-10 Menopause (age at onset); LUSC cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg17507749 chr15:85114479 UBE2QP1 0.54 5.97 0.31 5.93e-9 Schizophrenia; LUSC cis rs6582630 0.555 rs7294313 chr12:38323603 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.84 -0.39 6.28e-14 Drug-induced liver injury (flucloxacillin); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07336754 chr12:48921782 OR8S1 0.34 5.96 0.31 6.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12906019 chr1:228594265 TRIM11 0.48 7.05 0.36 1.02e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg26850624 chr5:429559 AHRR -0.38 -7.02 -0.36 1.21e-11 Cystic fibrosis severity; LUSC cis rs709400 0.628 rs11622320 chr14:103912194 A/T cg10523860 chr14:103875565 MARK3 -0.37 -5.68 -0.3 2.93e-8 Body mass index; LUSC cis rs9309473 1.000 rs13383871 chr2:73631779 T/C cg20560298 chr2:73613845 ALMS1 -0.44 -6.25 -0.32 1.23e-9 Metabolite levels; LUSC cis rs4776059 0.798 rs7167494 chr15:52928453 C/G cg22715398 chr15:52968154 KIAA1370 0.63 7.97 0.4 2.56e-14 Schizophrenia; LUSC trans rs11723530 0.513 rs6853761 chr4:170809568 G/T cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.14 -0.32 2.37e-9 Myopia (pathological); LUSC cis rs4285028 0.948 rs1920309 chr3:121665479 G/A cg11130432 chr3:121712080 ILDR1 -0.64 -9.78 -0.47 4.84e-20 Multiple sclerosis; LUSC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg10792982 chr14:105748885 BRF1 0.49 8.86 0.44 4.85e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg01097406 chr16:89675127 NA -0.35 -7.01 -0.36 1.32e-11 Vitiligo; LUSC cis rs9467773 0.572 rs3846846 chr6:26445039 A/G cg05738196 chr6:26577821 NA -0.52 -7.73 -0.39 1.28e-13 Intelligence (multi-trait analysis); LUSC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg26677194 chr12:130822605 PIWIL1 0.6 8.98 0.44 1.97e-17 Menopause (age at onset); LUSC cis rs7107174 1.000 rs10899455 chr11:77999163 T/C cg02023728 chr11:77925099 USP35 0.48 7.06 0.36 9.41e-12 Testicular germ cell tumor; LUSC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg02463440 chr8:22132932 PIWIL2 0.42 7.52 0.38 5.16e-13 Hypertriglyceridemia; LUSC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC trans rs208520 1.000 rs208527 chr6:66957209 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.34 -0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg03433033 chr1:76189801 ACADM -0.79 -13.0 -0.58 1.46e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg15073853 chr19:18549131 ISYNA1 -0.31 -5.75 -0.3 2.02e-8 Breast cancer; LUSC cis rs2952156 0.920 rs2247862 chr17:37829129 A/G cg20243544 chr17:37824526 PNMT 0.51 7.38 0.37 1.24e-12 Asthma; LUSC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg06108461 chr20:60628389 TAF4 -1.01 -17.41 -0.69 9.34e-49 Body mass index; LUSC cis rs11997175 0.545 rs66584807 chr8:33667609 A/G ch.8.33884649F chr8:33765107 NA 0.49 6.94 0.36 2.02e-11 Body mass index; LUSC cis rs35264875 1.000 rs35264875 chr11:68846399 A/T cg02660097 chr11:68866761 NA 0.43 6.02 0.31 4.63e-9 Blond vs. brown hair color; LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg05368731 chr17:41323189 NBR1 0.93 16.16 0.66 8.07e-44 Menopause (age at onset); LUSC cis rs6494488 0.500 rs72744707 chr15:65012000 G/C cg08069370 chr15:64387884 SNX1 -0.65 -5.92 -0.31 7.91e-9 Coronary artery disease; LUSC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg14541582 chr5:601475 NA -0.4 -6.14 -0.32 2.39e-9 Lung disease severity in cystic fibrosis; LUSC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg05025164 chr4:1340916 KIAA1530 0.4 6.14 0.32 2.31e-9 Obesity-related traits; LUSC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg06022373 chr22:39101656 GTPBP1 0.83 13.96 0.61 3.44e-35 Menopause (age at onset); LUSC cis rs12477438 0.765 rs10181422 chr2:99558970 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.42 -0.56 2.2e-29 Chronic sinus infection; LUSC cis rs9325144 0.600 rs34138871 chr12:38735261 A/G cg13010199 chr12:38710504 ALG10B 0.47 7.3 0.37 2.09e-12 Morning vs. evening chronotype; LUSC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg11941060 chr3:133502564 NA -0.42 -6.12 -0.32 2.68e-9 Iron status biomarkers; LUSC cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg02403541 chr12:121454288 C12orf43 0.76 12.34 0.56 4.34e-29 N-glycan levels; LUSC cis rs983392 0.667 rs634475 chr11:59942081 G/A cg20284999 chr11:59952153 MS4A6A 0.35 6.08 0.32 3.34e-9 Alzheimer's disease (late onset); LUSC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.2 -0.32 1.66e-9 Total body bone mineral density; LUSC trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg23505145 chr19:12996616 KLF1 -0.57 -9.55 -0.46 2.87e-19 Prostate cancer (SNP x SNP interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10727759 chr12:50017361 PRPF40B -0.51 -6.75 -0.35 6.41e-11 Bipolar disorder and schizophrenia; LUSC cis rs80130819 0.636 rs2732451 chr12:48719946 T/C cg24011408 chr12:48396354 COL2A1 0.45 5.81 0.3 1.42e-8 Prostate cancer; LUSC cis rs7100689 0.646 rs7092237 chr10:82165640 A/G cg00277334 chr10:82204260 NA -0.51 -7.66 -0.39 2.08e-13 Post bronchodilator FEV1; LUSC cis rs12753569 0.934 rs6593523 chr1:76486908 C/T cg00791851 chr1:76518896 NA -0.31 -5.89 -0.31 9.56e-9 Personality dimensions; LUSC cis rs2197308 0.659 rs11181327 chr12:37903171 C/T cg13010199 chr12:38710504 ALG10B -0.61 -9.46 -0.46 5.63e-19 Morning vs. evening chronotype; LUSC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg04398451 chr17:18023971 MYO15A 0.46 7.23 0.37 3.26e-12 Total body bone mineral density; LUSC cis rs1594829 0.553 rs2046225 chr8:26151802 A/C cg11498726 chr8:26250323 BNIP3L 0.34 5.72 0.3 2.42e-8 Height; LUSC cis rs394563 0.591 rs237028 chr6:149718650 C/T cg11245181 chr6:149772854 ZC3H12D -0.29 -6.36 -0.33 6.81e-10 Dupuytren's disease; LUSC cis rs6681460 1.000 rs6689864 chr1:67068112 T/C cg02459107 chr1:67143332 SGIP1 0.47 8.7 0.43 1.54e-16 Presence of antiphospholipid antibodies; LUSC cis rs9467773 1.000 rs1321479 chr6:26501897 C/T cg11502198 chr6:26597334 ABT1 -0.51 -7.69 -0.39 1.7e-13 Intelligence (multi-trait analysis); LUSC cis rs7674212 0.865 rs1481279 chr4:103977938 A/T cg16532752 chr4:104119610 CENPE 0.47 6.71 0.34 8.36e-11 Type 2 diabetes; LUSC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg11742103 chr11:62369870 EML3;MTA2 0.55 9.02 0.44 1.56e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.87 -0.31 1.07e-8 Platelet count; LUSC cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg11244672 chr19:19639970 YJEFN3 -0.62 -7.33 -0.37 1.78e-12 Bipolar disorder; LUSC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 8.56 0.42 4.32e-16 Electroencephalogram traits; LUSC trans rs7824557 0.670 rs2736381 chr8:11132766 A/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.28 -0.37 2.36e-12 Retinal vascular caliber; LUSC cis rs9837602 0.938 rs793457 chr3:99518987 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -5.71 -0.3 2.46e-8 Breast cancer; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.98 14.5 0.62 2.75e-37 Alzheimer's disease; LUSC cis rs4499344 0.920 rs2868149 chr19:33086096 C/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.6 -7.86 -0.4 5.19e-14 Mean platelet volume; LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg02951883 chr7:2050386 MAD1L1 -0.59 -11.06 -0.52 1.97e-24 Bipolar disorder and schizophrenia; LUSC cis rs6456156 0.586 rs7742305 chr6:167485723 C/T cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg11062466 chr8:58055876 NA -0.74 -9.15 -0.45 5.76e-18 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg06740227 chr12:86229804 RASSF9 0.44 7.09 0.36 7.84e-12 Major depressive disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23889236 chr11:706100 EPS8L2 0.73 6.07 0.32 3.52e-9 Cognitive performance; LUSC cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg10621924 chr7:39171070 POU6F2 0.41 6.16 0.32 2.13e-9 IgG glycosylation; LUSC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg03948781 chr1:205179583 DSTYK 0.3 5.7 0.3 2.6e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg05973401 chr12:123451056 ABCB9 -0.51 -6.89 -0.35 2.77e-11 Neutrophil percentage of white cells; LUSC trans rs6127471 1.000 rs1053931 chr20:36841293 A/G cg07165616 chr12:498868 KDM5A;CCDC77 -0.37 -5.95 -0.31 6.66e-9 Heart rate; LUSC cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg24558204 chr6:135376177 HBS1L 0.62 8.6 0.43 3.15e-16 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs12681288 0.550 rs59004371 chr8:962393 T/C cg04851639 chr8:1020857 NA -0.4 -7.97 -0.4 2.56e-14 Schizophrenia; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg25703541 chr22:24373054 LOC391322 -0.89 -14.5 -0.62 2.8e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17095355 1.000 rs75079039 chr10:111745121 T/C cg00817464 chr10:111662876 XPNPEP1 -0.65 -7.55 -0.38 4.18e-13 Biliary atresia; LUSC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg00750074 chr16:89608354 SPG7 0.55 10.22 0.49 1.6e-21 Multiple myeloma (IgH translocation); LUSC trans rs9291683 0.530 rs11723591 chr4:9985398 T/A cg26043149 chr18:55253948 FECH 0.5 7.75 0.39 1.14e-13 Bone mineral density; LUSC cis rs4566357 1.000 rs12612535 chr2:227926998 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.89 -0.31 9.43e-9 Coronary artery disease; LUSC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -6.94 -0.36 2.03e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11608355 0.538 rs10850074 chr12:109800531 T/C cg19025524 chr12:109796872 NA -0.42 -7.73 -0.39 1.31e-13 Neuroticism; LUSC cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg15541040 chr2:3486749 NA -0.53 -7.99 -0.4 2.27e-14 Neurofibrillary tangles; LUSC cis rs7215564 0.908 rs4536520 chr17:78660239 C/T cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs977987 0.966 rs6564261 chr16:75492242 C/T cg03315344 chr16:75512273 CHST6 0.5 9.4 0.46 8.68e-19 Dupuytren's disease; LUSC cis rs910316 0.763 rs6574205 chr14:75453039 G/C cg11812906 chr14:75593930 NEK9 0.66 10.94 0.51 5.29e-24 Height; LUSC cis rs5753618 0.561 rs5753609 chr22:31819212 A/G cg02404636 chr22:31891804 SFI1 0.44 6.52 0.34 2.54e-10 Colorectal cancer; LUSC cis rs12760731 0.565 rs11585236 chr1:178108441 G/A cg00404053 chr1:178313656 RASAL2 0.66 6.86 0.35 3.32e-11 Obesity-related traits; LUSC cis rs644799 0.542 rs10831417 chr11:95467262 A/G cg03916912 chr11:95522834 CEP57;FAM76B -0.65 -9.91 -0.48 1.84e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs868036 0.918 rs4238411 chr15:68079424 A/T cg05925327 chr15:68127851 NA -0.33 -5.96 -0.31 6.38e-9 Restless legs syndrome; LUSC cis rs9322817 0.503 rs6571205 chr6:105208813 A/C cg02098413 chr6:105308735 HACE1 -0.28 -5.72 -0.3 2.42e-8 Thyroid stimulating hormone; LUSC trans rs7726839 0.540 rs3792720 chr5:643028 T/G cg25482853 chr8:67687455 SGK3 1.1 15.74 0.65 3.91e-42 Obesity-related traits; LUSC cis rs116988415 0.584 rs78748209 chr14:65255676 C/T cg00114569 chr14:65239327 SPTB 0.71 7.41 0.38 1.03e-12 Daytime sleep phenotypes; LUSC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg12463550 chr7:65579703 CRCP 0.63 5.7 0.3 2.58e-8 Gout; LUSC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg14343924 chr8:8086146 FLJ10661 0.44 6.04 0.31 4.1e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2573652 1.000 rs2581358 chr15:100513725 C/G cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.36 -0.37 1.41e-12 Height; LUSC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg04315214 chr1:2043799 PRKCZ 0.4 7.98 0.4 2.33e-14 Height; LUSC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg16647868 chr5:131706066 SLC22A5 -0.4 -6.04 -0.31 4.03e-9 Blood metabolite levels; LUSC cis rs7937682 0.889 rs11213971 chr11:111529829 A/G cg09085632 chr11:111637200 PPP2R1B -1.09 -17.73 -0.7 4.82e-50 Primary sclerosing cholangitis; LUSC cis rs11229555 0.574 rs11229454 chr11:58203682 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg16339924 chr4:17578868 LAP3 0.49 7.53 0.38 4.83e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1355223 0.583 rs2941041 chr11:34874734 A/C cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.37 -0.37 1.33e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs4851254 0.660 rs35869550 chr2:100684578 T/A cg22139774 chr2:100720529 AFF3 -0.44 -5.82 -0.3 1.37e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg03676636 chr4:99064102 C4orf37 0.33 5.95 0.31 6.66e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg06008330 chr7:65541103 ASL 0.39 6.14 0.32 2.38e-9 Aortic root size; LUSC cis rs2235649 0.592 rs2429186 chr16:1969939 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -5.76 -0.3 1.95e-8 Blood metabolite levels; LUSC cis rs1728785 1.000 rs8058314 chr16:68584151 G/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg21856205 chr7:94953877 PON1 -0.36 -5.8 -0.3 1.56e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs73198271 0.628 rs56188408 chr8:8592158 G/C cg01851573 chr8:8652454 MFHAS1 0.46 5.77 0.3 1.83e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs965469 0.895 rs6051839 chr20:3391191 C/T cg25506879 chr20:3388711 C20orf194 0.55 6.28 0.33 1.04e-9 IFN-related cytopenia; LUSC cis rs2898290 0.622 rs11250140 chr8:11346592 A/C cg27411982 chr8:10470053 RP1L1 -0.41 -6.66 -0.34 1.13e-10 Systolic blood pressure; LUSC trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2197308 0.643 rs1842597 chr12:37862142 C/G cg13010199 chr12:38710504 ALG10B -0.62 -9.73 -0.47 7.43e-20 Morning vs. evening chronotype; LUSC cis rs3859192 0.599 rs2302777 chr17:38179492 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.7 12.65 0.57 3.08e-30 White blood cell count; LUSC cis rs911555 0.504 rs8021368 chr14:104074810 G/A cg12935359 chr14:103987150 CKB -0.51 -7.81 -0.39 7.69e-14 Intelligence (multi-trait analysis); LUSC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.47e-12 Lung disease severity in cystic fibrosis; LUSC cis rs7577696 0.962 rs212746 chr2:32413067 T/C cg02381751 chr2:32503542 YIPF4 0.42 6.02 0.31 4.65e-9 Inflammatory biomarkers; LUSC cis rs6539267 0.847 rs17217845 chr12:106697802 C/T cg00173435 chr12:106696525 TCP11L2 -0.55 -7.51 -0.38 5.46e-13 Tourette syndrome; LUSC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18404041 chr3:52824283 ITIH1 -0.52 -10.19 -0.49 2.09e-21 Bipolar disorder; LUSC cis rs1371867 0.875 rs1788187 chr8:101336099 A/G cg00191853 chr8:101177733 SPAG1 -0.39 -6.47 -0.33 3.49e-10 Atrioventricular conduction; LUSC cis rs2070488 0.775 rs1132064 chr3:38566519 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.68 -11.94 -0.55 1.37e-27 Electrocardiographic conduction measures; LUSC cis rs34172651 0.917 rs2112786 chr16:24778944 C/T cg00339695 chr16:24857497 SLC5A11 0.37 6.6 0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.89 -0.35 2.85e-11 Lung cancer; LUSC cis rs7827545 1.000 rs4909910 chr8:135565201 T/C cg17885191 chr8:135476712 NA 0.56 8.32 0.41 2.34e-15 Hypertension (SNP x SNP interaction); LUSC cis rs11098499 0.954 rs66506550 chr4:120371445 T/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs1577917 1.000 rs12203924 chr6:86776412 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.77 -0.35 5.91e-11 Response to antipsychotic treatment; LUSC cis rs907612 0.638 rs907611 chr11:1874072 G/A cg07277017 chr11:1874093 LSP1 0.34 6.0 0.31 5.23e-9 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg24642439 chr20:33292090 TP53INP2 0.72 11.82 0.54 3.45e-27 Coronary artery disease; LUSC trans rs7618501 0.633 rs55751738 chr3:49972101 A/G cg21659725 chr3:3221576 CRBN 0.63 10.53 0.5 1.38e-22 Intelligence (multi-trait analysis); LUSC cis rs11711311 0.866 rs13313893 chr3:113400856 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -5.85 -0.31 1.14e-8 IgG glycosylation; LUSC cis rs7577851 0.715 rs12612489 chr2:69640722 C/A cg10773587 chr2:69614142 GFPT1 0.57 7.11 0.36 7.1e-12 Parkinson's disease (age of onset); LUSC cis rs9323205 0.765 rs2999389 chr14:51654510 G/A cg23942311 chr14:51606299 NA 0.32 6.67 0.34 1.06e-10 Cancer; LUSC cis rs3820928 0.845 rs2177596 chr2:227890283 A/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.64 -0.39 2.33e-13 Pulmonary function; LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg20607798 chr8:58055168 NA -0.53 -5.95 -0.31 6.79e-9 Developmental language disorder (linguistic errors); LUSC cis rs8017423 1.000 rs4900028 chr14:90685594 C/T cg04374321 chr14:90722782 PSMC1 0.71 11.26 0.52 3.82e-25 Mortality in heart failure; LUSC cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg18681998 chr4:17616180 MED28 0.81 14.81 0.63 1.65e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25339705 chr17:48074418 NA -0.41 -6.13 -0.32 2.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9463078 0.817 rs3799978 chr6:44837532 A/G cg25276700 chr6:44698697 NA -0.3 -5.74 -0.3 2.12e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1692580 0.870 rs263532 chr1:2164116 T/C cg03732007 chr1:2071316 PRKCZ 0.36 5.85 0.3 1.16e-8 Coronary artery disease; LUSC cis rs11690935 0.959 rs77280952 chr2:172620151 G/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.26 -0.62 2.3e-36 Schizophrenia; LUSC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.52 7.03 0.36 1.2e-11 Tonsillectomy; LUSC cis rs1775715 0.677 rs2808074 chr10:32179184 A/C cg18675610 chr10:32216311 ARHGAP12 0.3 6.65 0.34 1.22e-10 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg16456906 chr16:69373271 NIP7;COG8 0.36 6.06 0.31 3.62e-9 Metabolite levels (Pyroglutamine); LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg26338869 chr17:61819248 STRADA 0.42 6.17 0.32 1.99e-9 Prudent dietary pattern; LUSC cis rs13242816 1.000 rs35538349 chr7:116117896 C/T cg16553024 chr7:116138462 CAV2 -0.52 -5.69 -0.3 2.81e-8 P wave duration; LUSC cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.02 -0.44 1.5e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg05283184 chr6:79620031 NA -0.46 -8.69 -0.43 1.71e-16 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.87 -0.31 1.07e-8 Platelet count; LUSC cis rs1577917 0.883 rs13212415 chr6:86608083 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.25 -0.32 1.22e-9 Response to antipsychotic treatment; LUSC cis rs644799 0.710 rs3748253 chr11:95519506 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 14.15 0.61 6.13e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.43 -7.99 -0.4 2.21e-14 Monocyte percentage of white cells; LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs2282802 0.685 rs1347143 chr5:139669386 A/G cg26211634 chr5:139558579 C5orf32 -0.38 -7.13 -0.36 6.07e-12 Intelligence (multi-trait analysis); LUSC cis rs4776059 1.000 rs12914047 chr15:52970993 G/A cg22715398 chr15:52968154 KIAA1370 -0.67 -9.55 -0.46 2.87e-19 Schizophrenia; LUSC cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg07606381 chr6:8435919 SLC35B3 0.73 12.27 0.56 7.85e-29 Motion sickness; LUSC cis rs75920871 0.588 rs6589580 chr11:116819873 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.49 -6.01 -0.31 4.84e-9 Subjective well-being; LUSC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg12560992 chr17:57184187 TRIM37 -0.82 -14.75 -0.63 2.92e-38 Intelligence (multi-trait analysis); LUSC cis rs1790761 0.692 rs638140 chr11:67333858 G/C cg23188684 chr11:67383651 NA 0.34 6.02 0.31 4.67e-9 Mean corpuscular volume; LUSC cis rs710216 0.827 rs841850 chr1:43402054 T/C cg03128534 chr1:43423976 SLC2A1 0.46 5.88 0.31 9.93e-9 Red cell distribution width; LUSC cis rs9807989 0.839 rs10192036 chr2:102968211 C/A cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC cis rs9549367 0.789 rs9549711 chr13:113900557 C/T cg00898013 chr13:113819073 PROZ -0.57 -8.06 -0.4 1.38e-14 Platelet distribution width; LUSC trans rs514406 0.929 rs12354395 chr1:53327663 A/G cg24643429 chr1:3562429 WDR8 0.33 6.04 0.31 4.2e-9 Monocyte count; LUSC trans rs9401746 0.564 rs494258 chr6:124785014 G/A cg16857858 chr7:27213984 HOXA10 0.53 6.13 0.32 2.48e-9 Bone mineral density (Ward's triangle area); LUSC cis rs11971779 0.584 rs34762928 chr7:139113168 T/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs478304 0.934 rs1193496 chr11:65537556 C/T cg08755490 chr11:65554678 OVOL1 -0.41 -5.94 -0.31 7.31e-9 Acne (severe); LUSC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs13401104 0.796 rs1466206 chr2:237121221 G/C cg19324714 chr2:237145437 ASB18 0.44 5.66 0.3 3.34e-8 Educational attainment; LUSC cis rs4343996 0.967 rs7791820 chr7:3353180 T/G cg21248987 chr7:3385318 SDK1 -0.39 -6.56 -0.34 2.05e-10 Motion sickness; LUSC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg22800045 chr5:56110881 MAP3K1 0.43 5.78 0.3 1.74e-8 Coronary artery disease; LUSC cis rs3126085 0.935 rs4845429 chr1:152225376 G/C cg26876637 chr1:152193138 HRNR 0.44 6.41 0.33 5.05e-10 Atopic dermatitis; LUSC cis rs6121246 0.529 rs6060359 chr20:30209740 A/G cg18721089 chr20:30220636 NA -0.39 -6.06 -0.31 3.74e-9 Mean corpuscular hemoglobin; LUSC cis rs12594515 1.000 rs56220882 chr15:45997075 C/G cg01629716 chr15:45996671 NA 0.39 5.82 0.3 1.37e-8 Waist circumference;Weight; LUSC cis rs10489525 0.599 rs34710929 chr1:115606608 G/A cg17147537 chr1:115611705 TSPAN2 0.29 5.99 0.31 5.35e-9 Autism; LUSC cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg16586182 chr3:47516702 SCAP 0.51 7.68 0.39 1.8e-13 Colorectal cancer; LUSC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11890956 chr21:40555474 PSMG1 1.04 20.95 0.75 8.37e-63 Cognitive function; LUSC cis rs11690935 0.589 rs2271758 chr2:172701157 T/G cg13550731 chr2:172543902 DYNC1I2 0.57 8.77 0.43 9.02e-17 Schizophrenia; LUSC cis rs8044995 0.568 rs55675218 chr16:68323647 G/C cg05110241 chr16:68378359 PRMT7 -0.76 -7.88 -0.4 4.78e-14 Schizophrenia; LUSC cis rs3087591 0.708 rs1129506 chr17:29646032 G/A cg24425628 chr17:29625626 OMG;NF1 0.49 7.3 0.37 2.09e-12 Hip circumference; LUSC cis rs10979 0.546 rs9496686 chr6:143908735 G/C cg25407410 chr6:143891975 LOC285740 -0.65 -8.17 -0.41 6.6e-15 Hypospadias; LUSC cis rs11758351 1.000 rs74363821 chr6:26189524 G/C cg23601095 chr6:26197514 HIST1H3D 0.72 7.61 0.38 2.89e-13 Gout;Renal underexcretion gout; LUSC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg06028605 chr16:24865363 SLC5A11 -0.68 -10.39 -0.49 4.11e-22 Intelligence (multi-trait analysis); LUSC cis rs4285028 0.848 rs4118376 chr3:121636450 G/A cg11130432 chr3:121712080 ILDR1 -0.65 -10.01 -0.48 8.72e-21 Multiple sclerosis; LUSC cis rs9359856 0.636 rs1179896 chr6:90318610 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -8.07 -0.4 1.27e-14 Bipolar disorder; LUSC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg21724239 chr8:58056113 NA 0.85 9.53 0.46 3.26e-19 Developmental language disorder (linguistic errors); LUSC cis rs6546537 0.955 rs35947226 chr2:69845829 C/G cg10773587 chr2:69614142 GFPT1 -0.54 -8.18 -0.41 5.83e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs7586879 0.828 rs7597157 chr2:25089166 C/T cg01884057 chr2:25150051 NA 0.4 8.15 0.41 7.46e-15 Body mass index; LUSC cis rs11030122 0.702 rs12281293 chr11:3963814 C/T cg08557956 chr11:4115526 RRM1 -0.45 -5.69 -0.3 2.74e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs4906332 1.000 rs7155980 chr14:103922419 C/G cg04998671 chr14:104000505 TRMT61A -0.44 -6.98 -0.36 1.62e-11 Coronary artery disease; LUSC cis rs6500395 1.000 rs3848319 chr16:48610933 T/C cg04672837 chr16:48644449 N4BP1 0.48 7.24 0.37 3.21e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg09365446 chr1:150670422 GOLPH3L -0.42 -6.24 -0.32 1.3e-9 Tonsillectomy; LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC trans rs11098499 0.863 rs13149407 chr4:120437825 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.62 0.38 2.71e-13 Corneal astigmatism; LUSC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg22907277 chr7:1156413 C7orf50 0.57 8.75 0.43 1.08e-16 Longevity;Endometriosis; LUSC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs10857712 0.754 rs2297032 chr10:135234580 C/T cg01444801 chr10:135216882 MTG1 -0.48 -6.32 -0.33 8.31e-10 Systemic lupus erythematosus; LUSC cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.22e-10 Aortic root size; LUSC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11644478 chr21:40555479 PSMG1 -0.81 -14.63 -0.62 8.75e-38 Cognitive function; LUSC cis rs9807989 0.839 rs9308857 chr2:102979624 G/A cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs1215050 0.755 rs2952911 chr4:98850666 T/C cg05340658 chr4:99064831 C4orf37 -0.44 -6.95 -0.36 1.94e-11 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7980799 0.682 rs7311794 chr12:33635630 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.2 -0.32 1.62e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg16434002 chr17:42200994 HDAC5 0.43 5.75 0.3 1.99e-8 Total body bone mineral density; LUSC cis rs6456156 0.586 rs13195158 chr6:167481392 G/A cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs11105298 0.685 rs117578503 chr12:89836672 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.3 -0.37 2.06e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs76419734 0.510 rs2216516 chr4:106749857 G/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.54 -6.01 -0.31 4.8e-9 Post bronchodilator FEV1; LUSC cis rs8016982 0.674 rs11159494 chr14:81667611 G/C cg01989461 chr14:81687754 GTF2A1 0.73 13.51 0.59 1.79e-33 Schizophrenia; LUSC cis rs10504073 0.545 rs4406405 chr8:49957261 G/C cg00325661 chr8:49890786 NA 0.7 11.16 0.52 8.89e-25 Blood metabolite ratios; LUSC cis rs7100689 0.784 rs17678947 chr10:82136333 T/C cg00277334 chr10:82204260 NA -0.48 -6.6 -0.34 1.65e-10 Post bronchodilator FEV1; LUSC cis rs9790314 0.846 rs6441371 chr3:161008727 C/A cg04691961 chr3:161091175 C3orf57 -0.35 -5.97 -0.31 6.09e-9 Morning vs. evening chronotype; LUSC cis rs7917772 0.582 rs10786687 chr10:104336994 A/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1153858 1.000 rs1049508 chr15:45653592 A/G cg26924012 chr15:45694286 SPATA5L1 1.13 20.62 0.75 1.62e-61 Homoarginine levels; LUSC cis rs1003719 0.591 rs1053984 chr21:38574018 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -9.01 -0.44 1.68e-17 Eye color traits; LUSC cis rs9660992 0.626 rs1172113 chr1:205226288 T/C cg00857998 chr1:205179979 DSTYK 0.59 9.03 0.44 1.39e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs11190604 1.000 rs10883511 chr10:102299407 A/G cg16342193 chr10:102329863 NA -0.36 -6.63 -0.34 1.37e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs34779708 0.931 rs4934702 chr10:35323074 T/C cg04310649 chr10:35416472 CREM -0.4 -6.22 -0.32 1.52e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3862030 0.720 rs7341995 chr10:104223831 G/A cg22532475 chr10:104410764 TRIM8 0.26 6.13 0.32 2.5e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7072216 0.763 rs3814140 chr10:100170762 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.86 -0.44 4.94e-17 Metabolite levels; LUSC cis rs9905704 0.918 rs2611783 chr17:56808530 A/G cg12560992 chr17:57184187 TRIM37 0.56 8.01 0.4 1.92e-14 Testicular germ cell tumor; LUSC cis rs11122272 0.735 rs2491407 chr1:231518928 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs2731664 0.756 rs4976695 chr5:176862963 T/A cg23176889 chr5:176863531 GRK6 -0.7 -14.28 -0.62 1.87e-36 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.582 rs7899004 chr10:104341435 C/T cg22532475 chr10:104410764 TRIM8 0.29 6.82 0.35 4.41e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg05425664 chr17:57184151 TRIM37 0.55 7.98 0.4 2.38e-14 Intelligence (multi-trait analysis); LUSC cis rs3815700 0.844 rs444089 chr19:33106991 G/C cg05355328 chr19:33096524 ANKRD27 0.59 5.65 0.3 3.36e-8 Eosinophilic esophagitis; LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.65e-9 Menopause (age at onset); LUSC cis rs7208859 0.573 rs11654035 chr17:29136426 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg23093090 chr10:104574429 C10orf26 -0.45 -8.35 -0.42 1.9e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.71 0.57 1.77e-30 Cognitive test performance; LUSC cis rs6582630 0.622 rs11182005 chr12:38441292 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.75e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -7.22 -0.37 3.63e-12 Response to bleomycin (chromatid breaks); LUSC cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg22681709 chr2:178499509 PDE11A -0.59 -11.87 -0.54 2.4e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs911555 0.755 rs8014800 chr14:103946302 T/C cg24130564 chr14:104152367 KLC1 0.46 6.55 0.34 2.17e-10 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04865506 chr17:29422776 NF1 0.5 7.0 0.36 1.39e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs73198271 0.740 rs10110711 chr8:8650456 C/T cg01851573 chr8:8652454 MFHAS1 0.52 8.45 0.42 9.33e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs6084875 0.840 rs6084858 chr20:4731109 A/G cg26257163 chr5:25190441 NA 0.36 6.07 0.32 3.41e-9 Systemic lupus erythematosus; LUSC trans rs61931739 0.534 rs4931772 chr12:34044590 G/A cg13010199 chr12:38710504 ALG10B 0.53 7.92 0.4 3.45e-14 Morning vs. evening chronotype; LUSC cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg06784218 chr1:46089804 CCDC17 0.48 9.34 0.45 1.43e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2486288 0.656 rs11631021 chr15:45556829 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.05 -0.4 1.48e-14 Glomerular filtration rate; LUSC cis rs1375194 0.606 rs13393407 chr2:33818198 C/T cg04131969 chr2:33951647 MYADML -0.59 -8.09 -0.4 1.1e-14 Response to antidepressants in depression; LUSC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg02772935 chr3:125709198 NA -0.47 -5.66 -0.3 3.26e-8 Blood pressure (smoking interaction); LUSC cis rs78545713 0.649 rs74928264 chr6:26224343 C/G cg23601095 chr6:26197514 HIST1H3D 0.66 5.79 0.3 1.64e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11098499 0.754 rs11732087 chr4:120239831 A/G cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg11764359 chr7:65958608 NA 0.7 10.95 0.51 4.71e-24 Aortic root size; LUSC cis rs7241530 0.775 rs11081529 chr18:75902735 C/T cg14642773 chr18:75888474 NA -0.34 -5.74 -0.3 2.18e-8 Educational attainment (years of education); LUSC cis rs28680850 1.000 rs28680850 chr8:1373720 G/A cg06016156 chr8:1399969 NA -0.41 -5.73 -0.3 2.29e-8 Triglycerides; LUSC cis rs8025790 0.508 rs4776370 chr15:67904511 T/C cg05925327 chr15:68127851 NA -0.41 -6.2 -0.32 1.65e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs477692 1.000 rs516704 chr10:131419879 G/A cg11019008 chr10:131425282 MGMT 0.39 5.93 0.31 7.58e-9 Response to temozolomide; LUSC cis rs7824557 0.564 rs2572379 chr8:11237480 A/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.79 -0.3 1.63e-8 Retinal vascular caliber; LUSC cis rs7833986 0.501 rs2976038 chr8:57028864 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.12 0.55 2.99e-28 Height; LUSC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg05234568 chr11:5960015 NA -0.6 -8.66 -0.43 2.01e-16 DNA methylation (variation); LUSC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg10523679 chr1:76189770 ACADM 0.9 16.2 0.66 6.04e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg13770153 chr20:60521292 NA -0.58 -7.69 -0.39 1.61e-13 Body mass index; LUSC cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.1 0.48 4.18e-21 Bipolar disorder; LUSC cis rs4363385 0.510 rs61815707 chr1:152909018 T/C cg00922841 chr1:152955080 SPRR1A -0.39 -6.49 -0.33 3.05e-10 Inflammatory skin disease; LUSC cis rs7809950 1.000 rs2712214 chr7:107188031 G/A cg23024343 chr7:107201750 COG5 -0.57 -8.96 -0.44 2.29e-17 Coronary artery disease; LUSC cis rs9796 0.870 rs4923890 chr15:41258990 T/C cg18705301 chr15:41695430 NDUFAF1 0.44 7.7 0.39 1.6e-13 Menopause (age at onset); LUSC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg00310523 chr12:86230176 RASSF9 0.45 8.34 0.42 2.01e-15 Major depressive disorder; LUSC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.59 0.38 3.1400000000000003e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs13006833 0.668 rs2582736 chr2:191144892 A/T cg21644426 chr2:191273491 MFSD6 0.44 6.28 0.33 1.03e-9 Urinary metabolites; LUSC cis rs56283067 0.847 rs60328783 chr6:44693099 C/G cg20913747 chr6:44695427 NA -0.49 -7.97 -0.4 2.54e-14 Total body bone mineral density; LUSC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg23711669 chr6:146136114 FBXO30 0.91 17.83 0.7 1.94e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg09796270 chr17:17721594 SREBF1 0.41 7.21 0.37 3.75e-12 Total body bone mineral density; LUSC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg23758822 chr17:41437982 NA 1.05 20.5 0.75 4.99e-61 Menopause (age at onset); LUSC cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg16797656 chr11:68205561 LRP5 0.48 8.89 0.44 3.96e-17 Total body bone mineral density; LUSC cis rs6500395 0.925 rs9933148 chr16:48672099 C/T cg04672837 chr16:48644449 N4BP1 0.47 6.94 0.35 2.06e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6486730 0.508 rs7133440 chr12:129269244 A/C cg09035930 chr12:129282057 SLC15A4 -0.46 -8.24 -0.41 3.99e-15 Systemic lupus erythematosus; LUSC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg06713675 chr4:122721982 EXOSC9 -0.72 -12.31 -0.56 5.85e-29 Type 2 diabetes; LUSC cis rs5758511 0.680 rs1033459 chr22:42619067 A/G cg00645731 chr22:42541494 CYP2D7P1 0.58 10.21 0.49 1.8e-21 Birth weight; LUSC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg05855489 chr10:104503620 C10orf26 0.59 9.42 0.46 7.54e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3820068 0.871 rs11585808 chr1:15805662 C/T cg17385448 chr1:15911702 AGMAT 0.41 5.7 0.3 2.57e-8 Systolic blood pressure; LUSC cis rs4948275 0.550 rs7904815 chr10:63136612 G/A cg02461363 chr10:63212496 TMEM26 -0.36 -5.85 -0.3 1.17e-8 Night sleep phenotypes; LUSC cis rs3540 0.512 rs17263706 chr15:91078803 G/T cg22089800 chr15:90895588 ZNF774 0.63 9.7 0.47 9.47e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs1878931 0.559 rs11643501 chr16:3392752 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.63 10.06 0.48 5.88e-21 Body mass index (adult); LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg21984481 chr17:79567631 NPLOC4 -0.72 -15.09 -0.64 1.31e-39 Eye color traits; LUSC cis rs425277 0.959 rs77665022 chr1:2065958 C/T cg24578937 chr1:2090814 PRKCZ 0.61 13.84 0.6 9.41e-35 Height; LUSC cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg16745616 chr19:8428856 ANGPTL4 -0.39 -5.86 -0.31 1.09e-8 HDL cholesterol; LUSC cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2625529 0.938 rs4776579 chr15:72132608 C/T cg16672083 chr15:72433130 SENP8 -0.5 -7.53 -0.38 4.9e-13 Red blood cell count; LUSC cis rs75804782 0.521 rs72994970 chr2:239426992 G/A cg18131467 chr2:239335373 ASB1 -0.7 -6.01 -0.31 4.98e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs9341808 0.529 rs9352826 chr6:81059371 C/T cg08355045 chr6:80787529 NA 0.47 7.86 0.4 5.35e-14 Sitting height ratio; LUSC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg25124228 chr12:125621409 AACS -0.59 -9.86 -0.47 2.67e-20 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4654899 0.758 rs6658679 chr1:21376451 T/C cg01072550 chr1:21505969 NA -0.52 -7.95 -0.4 2.94e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg05253716 chr12:129299332 SLC15A4;MGC16384 0.44 6.62 0.34 1.43e-10 Systemic lupus erythematosus; LUSC cis rs9346649 0.630 rs4708643 chr6:168491681 A/G cg02770688 chr6:168491649 NA 0.48 9.05 0.44 1.23e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg06618935 chr21:46677482 NA -0.37 -7.39 -0.37 1.21e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.865 rs11098513 chr4:120316075 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.5 0.38 5.86e-13 Corneal astigmatism; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg08130266 chr15:100890462 FLJ42289 0.38 6.06 0.31 3.67e-9 Mosquito bite size; LUSC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg03433033 chr1:76189801 ACADM 0.68 9.3 0.45 1.84e-18 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7709377 0.574 rs10063392 chr5:115499800 C/T cg23108291 chr5:115420582 COMMD10 0.41 5.88 0.31 9.74e-9 Metabolite levels (X-11787); LUSC cis rs2274273 0.564 rs10140164 chr14:55406123 A/G cg04306507 chr14:55594613 LGALS3 0.39 8.44 0.42 9.63e-16 Protein biomarker; LUSC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg09904177 chr6:26538194 HMGN4 0.49 7.46 0.38 7.63e-13 Schizophrenia; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg18934581 chr7:89976026 GTPBP10 -0.45 -6.75 -0.35 6.62e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7178572 0.568 rs12911371 chr15:77689050 C/T cg22256960 chr15:77711686 NA -0.5 -7.92 -0.4 3.57e-14 Type 2 diabetes; LUSC cis rs2274273 0.624 rs7157308 chr14:55782043 A/G cg04306507 chr14:55594613 LGALS3 0.47 9.47 0.46 5.46e-19 Protein biomarker; LUSC cis rs8017423 0.935 rs11159959 chr14:90733656 C/T cg04374321 chr14:90722782 PSMC1 -0.72 -10.42 -0.5 3.26e-22 Mortality in heart failure; LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.11 -0.48 3.97e-21 Obesity-related traits; LUSC cis rs4704187 0.712 rs7701262 chr5:74365986 C/T cg03227963 chr5:74354835 NA 0.33 7.01 0.36 1.32e-11 Response to amphetamines; LUSC cis rs637571 0.522 rs491973 chr11:65727301 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.49 9.23 0.45 3.23e-18 Eosinophil percentage of white cells; LUSC cis rs782590 0.537 rs12619903 chr2:55884106 T/A cg18811423 chr2:55921094 PNPT1 -0.63 -8.58 -0.43 3.57e-16 Metabolic syndrome; LUSC cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg06784218 chr1:46089804 CCDC17 -0.51 -9.86 -0.47 2.72e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1881797 0.527 rs78486847 chr1:247638515 C/T cg14830002 chr1:247616686 OR2B11 0.65 7.46 0.38 7.62e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs2273669 0.667 rs12195378 chr6:109284255 A/G cg05315195 chr6:109294784 ARMC2 -0.58 -6.47 -0.33 3.44e-10 Prostate cancer; LUSC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg04317338 chr11:64019027 PLCB3 0.71 8.02 0.4 1.84e-14 Mean platelet volume; LUSC trans rs4332037 0.707 rs56070303 chr7:1891015 C/T cg11693508 chr17:37793320 STARD3 0.51 6.3 0.33 9.61e-10 Bipolar disorder; LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg24642844 chr7:1081250 C7orf50 -0.81 -11.13 -0.52 1.06e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs427941 0.632 rs201526 chr7:101774333 T/G cg06246474 chr7:101738831 CUX1 0.37 6.04 0.31 4.12e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7586879 0.929 rs6545808 chr2:25124388 C/A cg01884057 chr2:25150051 NA 0.43 9.18 0.45 4.46e-18 Body mass index; LUSC cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg11266682 chr4:10021025 SLC2A9 0.57 10.52 0.5 1.49e-22 Bone mineral density; LUSC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg26061582 chr7:22766209 IL6 0.5 7.16 0.36 5.25e-12 Lung cancer; LUSC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg12257692 chr3:49977190 RBM6 0.24 6.57 0.34 1.89e-10 Intelligence (multi-trait analysis); LUSC trans rs7824557 0.778 rs6601572 chr8:11093337 C/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.37 -0.42 1.59e-15 Retinal vascular caliber; LUSC cis rs12940923 1.000 rs11079343 chr17:56369007 T/C cg19466818 chr17:56409534 MIR142 -0.39 -6.87 -0.35 3.19e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs6061231 0.755 rs11699160 chr20:60958651 T/C cg22601191 chr20:60968625 CABLES2 0.41 6.92 0.35 2.37e-11 Colorectal cancer; LUSC cis rs2439831 0.850 rs8023458 chr15:44080939 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.89 0.35 2.76e-11 Lung cancer in ever smokers; LUSC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg21433313 chr16:3507492 NAT15 0.66 11.02 0.52 2.68e-24 Tuberculosis; LUSC cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg05347473 chr6:146136440 FBXO30 -0.5 -8.52 -0.42 5.58e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.6 0.47 1.93e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6977940 0.730 rs11770451 chr7:2887990 G/T cg19346786 chr7:2764209 NA 0.54 5.96 0.31 6.28e-9 White matter integrity; LUSC cis rs4654899 0.802 rs17416732 chr1:21256368 T/C cg01072550 chr1:21505969 NA -0.48 -7.01 -0.36 1.35e-11 Superior frontal gyrus grey matter volume; LUSC cis rs11098499 1.000 rs7659194 chr4:120207147 T/G cg24375607 chr4:120327624 NA 0.74 11.32 0.53 2.24e-25 Corneal astigmatism; LUSC cis rs6426558 0.537 rs56219094 chr1:227340191 T/C cg10327440 chr1:227177885 CDC42BPA -0.54 -7.3 -0.37 2.18e-12 Neutrophil percentage of white cells; LUSC cis rs1448094 1.000 rs1448094 chr12:86343135 G/T cg18827107 chr12:86230957 RASSF9 -0.4 -5.92 -0.31 8.09e-9 Major depressive disorder; LUSC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg22800045 chr5:56110881 MAP3K1 0.8 10.13 0.48 3.29e-21 Initial pursuit acceleration; LUSC cis rs10746514 0.833 rs1888601 chr1:232266922 C/T cg09506761 chr1:232265262 NA -0.56 -9.71 -0.47 8.29e-20 Response to statin therapy; LUSC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg07870213 chr5:140052090 DND1 -0.75 -11.05 -0.52 2.15e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10045504 0.502 rs17352898 chr5:38745498 C/T cg15396434 chr5:38725168 NA -0.51 -5.73 -0.3 2.29e-8 Night sleep phenotypes; LUSC cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg23649088 chr2:200775458 C2orf69 -0.57 -7.0 -0.36 1.41e-11 Schizophrenia; LUSC cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg24642439 chr20:33292090 TP53INP2 0.48 7.22 0.37 3.45e-12 Glomerular filtration rate (creatinine); LUSC cis rs7582720 0.943 rs72932559 chr2:203847382 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.39 0.42 1.36e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs853679 0.882 rs9468300 chr6:28126840 C/T cg06606381 chr12:133084897 FBRSL1 -0.66 -7.19 -0.37 4.3e-12 Depression; LUSC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg12560992 chr17:57184187 TRIM37 0.89 17.59 0.69 1.84e-49 Intelligence (multi-trait analysis); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg14209926 chr17:79849790 ANAPC11;THOC4 -0.5 -6.27 -0.32 1.1e-9 Cognitive function;Information processing speed; LUSC cis rs7973719 0.865 rs12820829 chr12:7347534 G/A cg07052231 chr12:7363540 PEX5 0.53 9.2 0.45 4.11e-18 IgG glycosylation; LUSC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC cis rs4363385 0.791 rs512198 chr1:153006245 C/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.41 -0.38 1.03e-12 Inflammatory skin disease; LUSC cis rs72781680 0.898 rs72796154 chr2:23933839 G/A cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.48e-12 Lymphocyte counts; LUSC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg04369109 chr6:150039330 LATS1 -0.54 -7.97 -0.4 2.49e-14 Lung cancer; LUSC cis rs28374715 0.662 rs513280 chr15:41482800 T/C cg18705301 chr15:41695430 NDUFAF1 0.81 14.91 0.63 6.61e-39 Ulcerative colitis; LUSC trans rs2204008 0.774 rs11616004 chr12:38278822 G/A cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC trans rs2797160 0.967 rs2747718 chr6:126009109 C/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg05738196 chr6:26577821 NA 0.47 6.8 0.35 4.7e-11 Schizophrenia; LUSC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg11764359 chr7:65958608 NA 0.69 10.73 0.51 2.91e-23 Aortic root size; LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -6.13 -0.32 2.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs11997175 0.624 rs4593494 chr8:33692621 C/T ch.8.33884649F chr8:33765107 NA 0.42 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.57 0.46 2.47e-19 Bipolar disorder; LUSC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg21433313 chr16:3507492 NAT15 0.41 5.85 0.3 1.17e-8 Body mass index (adult); LUSC cis rs4148883 0.603 rs1893883 chr4:100124716 C/G cg12011299 chr4:100065546 ADH4 0.4 6.49 0.33 3.08e-10 Alcohol dependence; LUSC cis rs561341 0.609 rs2051810 chr17:30195841 C/T cg13647721 chr17:30228624 UTP6 -0.69 -7.48 -0.38 6.54e-13 Hip circumference adjusted for BMI; LUSC cis rs3008870 0.959 rs2815359 chr1:67494374 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.96 15.61 0.65 1.2e-41 Lymphocyte percentage of white cells; LUSC cis rs1448094 0.967 rs2044617 chr12:86324089 T/C cg00310523 chr12:86230176 RASSF9 0.4 7.33 0.37 1.8e-12 Major depressive disorder; LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg00166722 chr3:10149974 C3orf24 0.62 8.73 0.43 1.27e-16 Alzheimer's disease; LUSC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs10876993 0.749 rs703832 chr12:58024626 G/C cg18357645 chr12:58087776 OS9 0.49 7.08 0.36 8.66e-12 Celiac disease or Rheumatoid arthritis; LUSC cis rs6752107 1.000 rs2241880 chr2:234183368 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.78 0.54 4.92e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg17173187 chr15:85201210 NMB -0.34 -6.96 -0.36 1.78e-11 P wave terminal force; LUSC cis rs7267979 0.932 rs6115200 chr20:25487377 G/T cg08601574 chr20:25228251 PYGB 0.41 6.21 0.32 1.61e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg06092702 chr1:163392909 NA -0.47 -7.82 -0.39 7.14e-14 Motion sickness; LUSC cis rs1003719 0.715 rs8130643 chr21:38551715 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.55e-22 Eye color traits; LUSC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg21724239 chr8:58056113 NA 0.55 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg07507251 chr3:52567010 NT5DC2 0.34 6.72 0.35 7.76e-11 Bipolar disorder; LUSC cis rs2227564 0.729 rs2675676 chr10:75648287 A/C cg23231163 chr10:75533350 FUT11 -0.44 -6.11 -0.32 2.81e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.63 9.87 0.48 2.54e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9300255 0.739 rs12824957 chr12:123750228 T/C cg00376283 chr12:123451042 ABCB9 -0.72 -7.79 -0.39 8.48e-14 Neutrophil percentage of white cells; LUSC cis rs7829975 0.573 rs7842359 chr8:8797078 T/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.59 -0.43 3.43e-16 Mood instability; LUSC cis rs4356932 1.000 rs7684461 chr4:76962996 G/T cg00809888 chr4:76862425 NAAA -0.36 -6.03 -0.31 4.29e-9 Blood protein levels; LUSC cis rs929354 0.713 rs1034785 chr7:157002383 T/C cg05182265 chr7:156933206 UBE3C -0.6 -9.73 -0.47 7.38e-20 Body mass index; LUSC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg06134567 chr22:46658398 PKDREJ -0.46 -5.65 -0.3 3.48e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs10197940 0.532 rs13425170 chr2:152387112 A/C cg06191203 chr2:152266755 RIF1 -0.54 -6.75 -0.35 6.75e-11 Lung cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13769672 chr14:23398313 PRMT5 -0.47 -6.17 -0.32 2.01e-9 Hepatitis; LUSC cis rs477692 1.000 rs569235 chr10:131411620 T/C cg26102564 chr10:131424627 MGMT 0.44 6.97 0.36 1.75e-11 Response to temozolomide; LUSC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg16447950 chr5:562315 NA -0.58 -6.97 -0.36 1.66e-11 Lung disease severity in cystic fibrosis; LUSC cis rs9296092 0.538 rs9461880 chr6:33518714 C/T cg13560919 chr6:33536144 NA -0.82 -15.72 -0.65 4.63e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs79839061 0.610 rs17781499 chr4:889384 C/A cg14530993 chr4:882597 GAK 0.69 6.88 0.35 2.95e-11 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg11494091 chr17:61959527 GH2 0.66 13.88 0.6 6.84e-35 Prudent dietary pattern; LUSC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg07959070 chr22:50026188 C22orf34 0.38 7.98 0.4 2.44e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs62400317 0.859 rs2038765 chr6:45076494 A/G cg20913747 chr6:44695427 NA -0.46 -7.42 -0.38 9.56e-13 Total body bone mineral density; LUSC cis rs72717009 0.825 rs11810143 chr1:161480649 A/G cg23840854 chr1:161414152 NA -0.92 -11.27 -0.53 3.36e-25 Rheumatoid arthritis; LUSC cis rs11971779 0.648 rs4732367 chr7:139028102 A/C cg23387468 chr7:139079360 LUC7L2 0.42 6.28 0.32 1.06e-9 Diisocyanate-induced asthma; LUSC cis rs4363385 0.747 rs946100 chr1:152971663 C/T cg00922841 chr1:152955080 SPRR1A 0.46 8.08 0.4 1.23e-14 Inflammatory skin disease; LUSC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg14583973 chr4:3374767 RGS12 0.37 8.08 0.4 1.21e-14 Serum sulfate level; LUSC cis rs2274273 0.682 rs1187876 chr14:55495199 A/T cg04306507 chr14:55594613 LGALS3 -0.49 -10.86 -0.51 1.01e-23 Protein biomarker; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9303401 0.659 rs2072316 chr17:56604813 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.95 0.58 2.35e-31 Cognitive test performance; LUSC cis rs11190604 1.000 rs7070776 chr10:102264672 A/G cg23241863 chr10:102295624 HIF1AN 0.48 6.02 0.31 4.55e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs601339 0.536 rs575171 chr12:123194635 C/T cg11919336 chr12:123188078 GPR109A 0.4 5.75 0.3 2.02e-8 Adiponectin levels; LUSC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg26408565 chr15:76604113 ETFA -0.5 -8.05 -0.4 1.46e-14 Blood metabolite levels; LUSC cis rs3771570 1.000 rs1984598 chr2:242284824 G/A cg21155796 chr2:242212141 HDLBP 0.53 6.1 0.32 3e-9 Prostate cancer; LUSC cis rs11690935 0.959 rs35391289 chr2:172634983 A/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.42 -0.62 5.36e-37 Schizophrenia; LUSC cis rs17095355 1.000 rs734164 chr10:111698160 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.6 -0.38 2.95e-13 Biliary atresia; LUSC cis rs4631830 1.000 rs4631830 chr10:51543344 C/T cg20129853 chr10:51489980 NA -0.31 -6.12 -0.32 2.6e-9 Prostate-specific antigen levels; LUSC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg18252515 chr7:66147081 NA 1.2 13.69 0.6 3.51e-34 Diabetic kidney disease; LUSC cis rs1577917 0.740 rs2842614 chr6:86306069 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -9.53 -0.46 3.28e-19 Response to antipsychotic treatment; LUSC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg06671706 chr8:8559999 CLDN23 0.49 6.61 0.34 1.52e-10 Obesity-related traits; LUSC cis rs7582180 0.652 rs4851307 chr2:100971778 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.72 -0.43 1.34e-16 Intelligence (multi-trait analysis); LUSC cis rs9388451 0.839 rs3799709 chr6:126078361 A/G cg10911889 chr6:126070802 HEY2 0.42 6.49 0.33 3.07e-10 Brugada syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12942139 chr22:37823517 ELFN2 0.45 6.12 0.32 2.59e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg18225595 chr11:63971243 STIP1 0.55 9.53 0.46 3.44e-19 Platelet count; LUSC cis rs1577917 1.000 rs34281561 chr6:86701872 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.73 -0.43 1.22e-16 Response to antipsychotic treatment; LUSC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg17971929 chr21:40555470 PSMG1 0.68 11.47 0.53 6.49e-26 Cognitive function; LUSC cis rs7786808 0.544 rs6971888 chr7:158193835 G/A cg09998033 chr7:158218633 PTPRN2 0.46 7.23 0.37 3.27e-12 Obesity-related traits; LUSC cis rs9788682 1.000 rs7181447 chr15:78814567 A/G cg24631222 chr15:78858424 CHRNA5 0.83 11.48 0.53 5.98e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9399401 0.667 rs11759653 chr6:142720354 G/A cg03128060 chr6:142623767 GPR126 0.58 9.64 0.47 1.45e-19 Chronic obstructive pulmonary disease; LUSC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg07936489 chr17:37558343 FBXL20 -0.73 -10.03 -0.48 7.27e-21 Glomerular filtration rate (creatinine); LUSC cis rs2835872 0.828 rs2835837 chr21:38990443 C/T cg20424643 chr21:39039972 KCNJ6 0.38 5.98 0.31 5.62e-9 Electroencephalographic traits in alcoholism; LUSC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg01579765 chr21:45077557 HSF2BP -0.55 -11.49 -0.53 5.85e-26 Mean corpuscular volume; LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7937682 0.883 rs512669 chr11:111467893 G/A cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg17376030 chr22:41985996 PMM1 -0.48 -5.9 -0.31 8.9e-9 Vitiligo; LUSC cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg00071950 chr4:10020882 SLC2A9 -0.49 -8.21 -0.41 4.81e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs760805 1.000 rs4649037 chr1:25258301 G/T cg22509179 chr1:25234806 RUNX3 -0.6 -10.08 -0.48 4.72e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9486719 1.000 rs12529248 chr6:96895377 T/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg07424592 chr7:64974309 NA 0.66 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs11098499 0.909 rs10017335 chr4:120381523 C/G cg09307838 chr4:120376055 NA -0.68 -9.68 -0.47 1.09e-19 Corneal astigmatism; LUSC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg03929089 chr4:120376271 NA -1.03 -20.16 -0.74 1.07e-59 Height; LUSC cis rs76878669 0.561 rs12420203 chr11:66163794 T/C cg24851651 chr11:66362959 CCS -0.38 -6.06 -0.31 3.72e-9 Educational attainment (years of education); LUSC trans rs1814175 0.904 rs7924371 chr11:49620595 C/T cg03929089 chr4:120376271 NA -0.98 -17.61 -0.69 1.49e-49 Height; LUSC cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.64 6.73 0.35 7.46e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.57 -8.37 -0.42 1.57e-15 Gut microbiome composition (summer); LUSC cis rs7098414 0.511 rs10788603 chr10:82148137 G/T cg00277334 chr10:82204260 NA -0.56 -8.95 -0.44 2.58e-17 Post bronchodilator FEV1; LUSC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.66 -0.34 1.1e-10 Mean platelet volume; LUSC cis rs9399137 0.507 rs7771310 chr6:135272535 G/A cg24558204 chr6:135376177 HBS1L 0.67 10.05 0.48 6.35e-21 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs3008870 1.000 rs12041926 chr1:67434602 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.93 15.25 0.64 3.33e-40 Lymphocyte percentage of white cells; LUSC cis rs7937682 1.000 rs7121011 chr11:111568681 C/T cg19812747 chr11:111475976 SIK2 0.5 6.81 0.35 4.44e-11 Primary sclerosing cholangitis; LUSC cis rs12999616 0.817 rs17695937 chr2:98327875 A/G cg26665480 chr2:98280029 ACTR1B 0.53 6.05 0.31 3.91e-9 Colorectal cancer; LUSC cis rs12681288 0.823 rs2701908 chr8:1003250 T/C cg15309053 chr8:964076 NA 0.34 6.89 0.35 2.87e-11 Schizophrenia; LUSC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg23630131 chr7:65973040 NA -0.21 -6.01 -0.31 4.93e-9 Aortic root size; LUSC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg13683864 chr3:40499215 RPL14 -0.94 -15.96 -0.66 5.24e-43 Renal cell carcinoma; LUSC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg09455208 chr3:40491958 NA 0.52 9.62 0.47 1.74e-19 Renal cell carcinoma; LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.43 0.33 4.34e-10 Menopause (age at onset); LUSC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg11871910 chr12:69753446 YEATS4 0.94 17.4 0.69 1.05e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs9494145 0.680 rs9389269 chr6:135427159 T/C cg22676075 chr6:135203613 NA 0.63 8.9 0.44 3.53e-17 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs3820928 1.000 rs978909 chr2:227771389 A/C cg11843606 chr2:227700838 RHBDD1 -0.57 -8.34 -0.42 1.93e-15 Pulmonary function; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg22907277 chr7:1156413 C7orf50 0.45 6.82 0.35 4.19e-11 Longevity;Endometriosis; LUSC cis rs9549367 0.773 rs9549717 chr13:113908826 A/G cg00898013 chr13:113819073 PROZ -0.53 -7.85 -0.39 5.78e-14 Platelet distribution width; LUSC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg03732007 chr1:2071316 PRKCZ 0.55 9.97 0.48 1.12e-20 Height; LUSC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg04727924 chr7:799746 HEATR2 -0.57 -6.06 -0.31 3.75e-9 Cerebrospinal P-tau181p levels; LUSC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg26597838 chr10:835615 NA 0.97 12.93 0.58 2.68e-31 Eosinophil percentage of granulocytes; LUSC cis rs4930103 0.935 rs2071095 chr11:2020627 C/A cg06197492 chr11:2016605 H19 0.42 6.94 0.35 2.08e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs8060686 0.641 rs79719939 chr16:68240216 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.39 -0.33 5.59e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs77741769 0.553 rs12372231 chr12:121351729 T/A cg02419362 chr12:121203948 SPPL3 0.45 8.4 0.42 1.31e-15 Mean corpuscular volume; LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg02709834 chr1:75198841 CRYZ;TYW3 0.37 5.65 0.3 3.43e-8 Resistin levels; LUSC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC trans rs17086172 0.841 rs76001318 chr18:70271977 G/A cg15710198 chr8:55370334 SOX17 -0.67 -6.11 -0.32 2.82e-9 Airflow obstruction; LUSC cis rs9311676 0.632 rs62258075 chr3:58359851 G/A cg13750441 chr3:58318267 PXK 0.34 6.5 0.34 2.86e-10 Systemic lupus erythematosus; LUSC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg03709012 chr19:19516395 GATAD2A 0.74 11.3 0.53 2.7e-25 Tonsillectomy; LUSC cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.58 7.78 0.39 9.25e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs17154702 0.506 rs78790499 chr8:8628827 T/C cg01851573 chr8:8652454 MFHAS1 0.61 7.0 0.36 1.39e-11 Neurocognitive impairment in HIV-1 infection (continuous); LUSC cis rs35883536 0.626 rs7545966 chr1:101047633 G/A cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC cis rs4474465 0.920 rs10899526 chr11:78206157 T/C cg27205649 chr11:78285834 NARS2 0.5 5.97 0.31 5.93e-9 Alzheimer's disease (survival time); LUSC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg24881330 chr22:46731750 TRMU 0.85 7.57 0.38 3.77e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.13 0.55 2.73e-28 Prudent dietary pattern; LUSC cis rs1790761 0.632 rs625978 chr11:67344664 C/T cg23188684 chr11:67383651 NA 0.35 6.19 0.32 1.81e-9 Mean corpuscular volume; LUSC cis rs6495122 0.651 rs11636952 chr15:75114322 T/C cg10253484 chr15:75165896 SCAMP2 -0.43 -6.03 -0.31 4.43e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs9326248 0.559 rs12808524 chr11:116890993 T/C cg11861562 chr11:117069780 TAGLN 0.33 6.19 0.32 1.81e-9 Blood protein levels; LUSC cis rs2115630 0.967 rs10438428 chr15:85330745 C/T cg09876464 chr15:85330779 ZNF592 0.35 6.6 0.34 1.62e-10 P wave terminal force; LUSC trans rs7829975 0.688 rs13270194 chr8:8378102 T/C cg27411982 chr8:10470053 RP1L1 0.45 7.35 0.37 1.52e-12 Mood instability; LUSC trans rs7726839 0.718 rs6887972 chr5:597274 C/G cg25482853 chr8:67687455 SGK3 0.79 10.99 0.52 3.39e-24 Obesity-related traits; LUSC cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg16447950 chr5:562315 NA -0.53 -7.11 -0.36 7.28e-12 Obesity-related traits; LUSC cis rs9326248 0.911 rs474339 chr11:117059552 G/A cg26566898 chr11:117069891 TAGLN 0.48 8.37 0.42 1.58e-15 Blood protein levels; LUSC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg08132940 chr7:1081526 C7orf50 -0.48 -6.28 -0.33 1.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg14416269 chr4:6271139 WFS1 0.51 10.86 0.51 9.78e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs981844 0.775 rs17299246 chr4:154743504 C/T cg14289246 chr4:154710475 SFRP2 0.48 6.33 0.33 7.69e-10 Response to statins (LDL cholesterol change); LUSC cis rs7954584 0.567 rs11043246 chr12:122368944 G/A cg10207240 chr12:122356781 WDR66 0.45 6.44 0.33 4.25e-10 Mean corpuscular volume; LUSC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg12365402 chr11:9010492 NRIP3 0.47 8.62 0.43 2.64e-16 Hemoglobin concentration; LUSC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg15145296 chr3:125709740 NA -0.57 -6.36 -0.33 6.67e-10 Blood pressure (smoking interaction); LUSC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg04800585 chr6:26043546 HIST1H2BB 0.41 5.85 0.3 1.16e-8 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.85 -0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg06238570 chr21:40685208 BRWD1 0.46 7.08 0.36 8.78e-12 Cognitive function; LUSC cis rs17270561 0.609 rs4145216 chr6:25743559 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.73 0.39 1.29e-13 Iron status biomarkers; LUSC cis rs9807989 0.507 rs1420096 chr2:103010912 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.54e-12 Asthma; LUSC trans rs35952432 1 rs35952432 chr6:28074901 C/T cg06606381 chr12:133084897 FBRSL1 -1.05 -9.08 -0.44 9.63e-18 Lung cancer; LUSC cis rs7903847 0.596 rs11189203 chr10:99159096 C/A cg08345082 chr10:99160200 RRP12 -0.34 -7.03 -0.36 1.16e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.75 0.35 6.4e-11 Tonsillectomy; LUSC cis rs7267979 1.000 rs6050564 chr20:25344231 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -7.96 -0.4 2.74e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs8062405 0.964 rs11864107 chr16:28885931 T/C cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7267979 0.966 rs2261795 chr20:25263136 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.87 20.1 0.74 1.86e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs868036 0.560 rs12443086 chr15:68080454 C/A cg08079166 chr15:68083412 MAP2K5 0.37 7.79 0.39 8.48e-14 Restless legs syndrome; LUSC cis rs3749237 0.964 rs2234385 chr3:49846041 G/A cg05072774 chr3:49840536 C3orf54 -0.43 -5.96 -0.31 6.27e-9 Resting heart rate; LUSC cis rs5758659 0.737 rs10854749 chr22:42447341 G/T cg04733989 chr22:42467013 NAGA 0.44 7.24 0.37 3.05e-12 Cognitive function; LUSC cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg00339695 chr16:24857497 SLC5A11 0.39 6.64 0.34 1.28e-10 Intelligence (multi-trait analysis); LUSC trans rs3942852 0.568 rs10769314 chr11:48097620 C/T cg03929089 chr4:120376271 NA -0.58 -7.49 -0.38 6.14e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg13852791 chr20:30311386 BCL2L1 0.84 10.51 0.5 1.67e-22 Mean corpuscular hemoglobin; LUSC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg08704250 chr15:31115839 NA -0.59 -8.9 -0.44 3.68e-17 Huntington's disease progression; LUSC cis rs9326248 0.581 rs12804122 chr11:116902616 C/G cg11861562 chr11:117069780 TAGLN 0.32 6.2 0.32 1.64e-9 Blood protein levels; LUSC cis rs4680 0.737 rs4818 chr22:19951207 C/G cg22546130 chr22:19950026 COMT -0.37 -7.8 -0.39 8.04e-14 Blood metabolite levels; LUSC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg16339924 chr4:17578868 LAP3 0.67 10.81 0.51 1.43e-23 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg10523679 chr1:76189770 ACADM 0.81 14.1 0.61 9.37e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6969780 0.915 rs12666926 chr7:27189561 A/G cg26364809 chr7:27145159 NA 0.54 6.0 0.31 5.1e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg13560548 chr3:10150139 C3orf24 0.54 7.68 0.39 1.8e-13 Alzheimer's disease; LUSC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg22437258 chr11:111473054 SIK2 -0.44 -5.84 -0.3 1.23e-8 Primary sclerosing cholangitis; LUSC cis rs2404602 0.692 rs34287706 chr15:76942402 A/C cg26408565 chr15:76604113 ETFA -0.47 -7.48 -0.38 6.44e-13 Blood metabolite levels; LUSC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg14004847 chr7:1930337 MAD1L1 -0.53 -7.73 -0.39 1.29e-13 Bipolar disorder and schizophrenia; LUSC cis rs12760731 0.720 rs1994233 chr1:178269823 C/T cg00404053 chr1:178313656 RASAL2 -0.59 -6.5 -0.33 3e-10 Obesity-related traits; LUSC cis rs67478160 0.619 rs12437066 chr14:104236844 A/C cg08213375 chr14:104286397 PPP1R13B 0.47 9.18 0.45 4.76e-18 Schizophrenia; LUSC cis rs73198271 0.562 rs3827810 chr8:8659040 T/G cg01851573 chr8:8652454 MFHAS1 0.67 8.92 0.44 3.16e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10911251 0.546 rs1051473 chr1:183114146 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.62 0.5 6.58e-23 Colorectal cancer; LUSC cis rs8060686 0.668 rs2418739 chr16:68092850 G/C cg09835421 chr16:68378352 PRMT7 -0.45 -5.91 -0.31 8.47e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11890956 chr21:40555474 PSMG1 1.01 20.01 0.74 4.2e-59 Cognitive function; LUSC cis rs9616064 0.506 rs2073275 chr22:47070432 G/C cg05621596 chr22:47072043 GRAMD4 -0.59 -9.3 -0.45 1.89e-18 Urate levels in obese individuals; LUSC cis rs6964587 0.839 rs13246743 chr7:91453945 G/T cg17063962 chr7:91808500 NA 0.56 8.55 0.42 4.59e-16 Breast cancer; LUSC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg15423357 chr2:25149977 NA 0.44 8.93 0.44 2.98e-17 Body mass index; LUSC cis rs9311676 0.632 rs6774577 chr3:58361716 A/G cg26110898 chr3:58419937 PDHB 0.41 6.52 0.34 2.53e-10 Systemic lupus erythematosus; LUSC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg12311346 chr5:56204834 C5orf35 -0.57 -8.75 -0.43 1.09e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs12122100 0.507 rs1925343 chr1:146505535 A/T cg03526459 chr1:146549940 NA -0.4 -7.11 -0.36 7.12e-12 HIV-1 control; LUSC cis rs6547741 1.000 rs6749052 chr2:27772879 A/T cg12559939 chr2:27858050 GPN1 0.41 6.38 0.33 5.85e-10 Oral cavity cancer; LUSC cis rs9287719 0.649 rs10207885 chr2:10733188 C/T cg00105475 chr2:10696890 NA 0.35 5.78 0.3 1.7e-8 Prostate cancer; LUSC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg08499158 chr17:42289980 UBTF 0.42 6.38 0.33 5.78e-10 Total body bone mineral density; LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg10802521 chr3:52805072 NEK4 -0.54 -8.51 -0.42 6e-16 Bipolar disorder; LUSC cis rs11190604 1.000 rs3793772 chr10:102222825 A/G cg07080220 chr10:102295463 HIF1AN 0.62 8.3 0.41 2.57e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg06636001 chr8:8085503 FLJ10661 0.85 14.77 0.63 2.42e-38 Neuroticism; LUSC cis rs9814567 1.000 rs6802654 chr3:134217072 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.75 -0.6 2.1e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs500891 0.553 rs3812142 chr6:84141393 T/C cg08257003 chr6:84140564 ME1 0.38 9.32 0.45 1.58e-18 Platelet-derived growth factor BB levels; LUSC cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg00071950 chr4:10020882 SLC2A9 0.5 8.37 0.42 1.63e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg12432903 chr7:1882776 MAD1L1 -0.36 -5.82 -0.3 1.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg04944784 chr2:26401820 FAM59B 0.7 9.88 0.48 2.3e-20 Gut microbiome composition (summer); LUSC cis rs7582180 0.606 rs4851299 chr2:100954191 C/A cg12002119 chr2:101014098 CHST10 0.34 5.65 0.3 3.48e-8 Intelligence (multi-trait analysis); LUSC trans rs877282 0.853 rs12779017 chr10:763619 T/C cg13042288 chr15:90349979 ANPEP -0.47 -6.42 -0.33 4.59e-10 Uric acid levels; LUSC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg17971929 chr21:40555470 PSMG1 0.77 13.03 0.58 1.14e-31 Cognitive function; LUSC cis rs7659604 0.502 rs10013916 chr4:122702179 T/G cg19748678 chr4:122722346 EXOSC9 -0.5 -7.38 -0.37 1.23e-12 Type 2 diabetes; LUSC cis rs7524258 0.901 rs11120884 chr1:7305361 C/A cg07173049 chr1:7289937 CAMTA1 0.33 6.76 0.35 6.26e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC trans rs67340775 0.541 rs200979 chr6:27852357 G/A cg06606381 chr12:133084897 FBRSL1 -0.52 -5.95 -0.31 6.76e-9 Lung cancer in ever smokers; LUSC cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg24060327 chr5:131705240 SLC22A5 -0.4 -6.55 -0.34 2.16e-10 Blood metabolite levels; LUSC cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.15 -0.45 5.74e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg08999081 chr20:33150536 PIGU 0.54 11.08 0.52 1.69e-24 Coronary artery disease; LUSC cis rs2486288 0.656 rs11632777 chr15:45551045 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.02e-14 Glomerular filtration rate; LUSC cis rs950776 0.648 rs57945453 chr15:78862845 C/T cg06917634 chr15:78832804 PSMA4 0.71 11.33 0.53 2.17e-25 Sudden cardiac arrest; LUSC cis rs11122272 0.735 rs2572248 chr1:231514942 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs7666738 0.546 rs3911415 chr4:98692401 T/A cg17366294 chr4:99064904 C4orf37 0.54 8.53 0.42 5.3e-16 Colonoscopy-negative controls vs population controls; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg26446717 chr5:175788958 KIAA1191 0.4 6.05 0.31 3.8e-9 Schizophrenia (age at onset); LUSC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.78 0.3 1.69e-8 Self-reported allergy; LUSC cis rs6750795 0.569 rs1667313 chr2:232408018 A/C cg19187155 chr2:232395269 NMUR1 0.79 13.67 0.6 4.13e-34 Height; LUSC cis rs4319547 0.698 rs10744217 chr12:122942070 A/G cg23029597 chr12:123009494 RSRC2 -0.7 -9.13 -0.45 6.8e-18 Body mass index; LUSC cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg25427524 chr10:38739819 LOC399744 0.44 7.46 0.38 7.7e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg04850211 chr1:228464232 OBSCN 0.31 5.68 0.3 2.86e-8 Diastolic blood pressure; LUSC trans rs853679 0.517 rs9380050 chr6:28048538 A/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg15445000 chr17:37608096 MED1 -0.38 -6.46 -0.33 3.79e-10 Glomerular filtration rate (creatinine); LUSC cis rs4356932 0.967 rs10016135 chr4:76974579 T/C cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg03213289 chr20:61660250 NA -0.67 -13.36 -0.59 6.69e-33 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg22535103 chr8:58192502 C8orf71 0.71 7.81 0.39 7.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs7208859 0.623 rs57486336 chr17:29085731 G/T cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs7824557 0.564 rs7821459 chr8:11236681 T/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.54 -0.38 4.51e-13 Retinal vascular caliber; LUSC cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg24692254 chr21:30365293 RNF160 -0.81 -15.08 -0.64 1.53e-39 Dental caries; LUSC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg07936489 chr17:37558343 FBXL20 0.7 9.77 0.47 5.43e-20 Glomerular filtration rate (creatinine); LUSC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg15468180 chr1:107600409 PRMT6 -0.35 -5.72 -0.3 2.33e-8 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs2012796 0.956 rs10450940 chr14:81825326 C/A cg02996355 chr14:81879375 NA 0.5 7.25 0.37 2.83e-12 Night sleep phenotypes; LUSC trans rs2048656 0.523 rs1976673 chr8:9679780 T/A cg06636001 chr8:8085503 FLJ10661 0.47 6.58 0.34 1.82e-10 Schizophrenia; LUSC cis rs3741151 0.686 rs7118982 chr11:73110668 T/C cg17517138 chr11:73019481 ARHGEF17 0.82 7.84 0.39 6.15e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs1493916 0.870 rs7235698 chr18:31382486 A/G cg13755796 chr4:20253514 NA -0.43 -6.8 -0.35 4.7e-11 Life satisfaction; LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg25703541 chr22:24373054 LOC391322 1.0 19.79 0.73 3.25e-58 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg12963246 chr6:28129442 ZNF389 0.45 5.94 0.31 7e-9 Depression; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg04518342 chr5:131593106 PDLIM4 0.52 9.47 0.46 5.25e-19 Acylcarnitine levels; LUSC cis rs113835537 0.529 rs80100524 chr11:66245936 C/T cg24851651 chr11:66362959 CCS 0.55 8.16 0.41 6.79e-15 Airway imaging phenotypes; LUSC cis rs10779751 0.610 rs2486921 chr1:11124943 G/A cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC trans rs7726839 0.574 rs12517345 chr5:628294 G/A cg11887960 chr12:57824829 NA 0.53 6.6 0.34 1.59e-10 Obesity-related traits; LUSC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11644478 chr21:40555479 PSMG1 -0.82 -14.63 -0.63 8.24e-38 Cognitive function; LUSC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg20135002 chr11:47629003 NA -0.53 -8.43 -0.42 1.03e-15 Subjective well-being; LUSC cis rs782590 0.935 rs2627779 chr2:55892356 A/G cg03859395 chr2:55845619 SMEK2 0.91 16.85 0.68 1.56e-46 Metabolic syndrome; LUSC cis rs7582720 1.000 rs72934753 chr2:203750272 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6495122 0.501 rs8039755 chr15:75337426 T/C cg14664628 chr15:75095509 CSK 0.43 6.16 0.32 2.11e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs4343996 0.727 rs10951159 chr7:3370465 G/T cg21248987 chr7:3385318 SDK1 -0.35 -6.02 -0.31 4.66e-9 Motion sickness; LUSC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4423214 0.840 rs1792231 chr11:71182681 G/A cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC trans rs561341 0.831 rs11658469 chr17:30206426 T/C cg20587970 chr11:113659929 NA 1.12 13.33 0.59 8.6e-33 Hip circumference adjusted for BMI; LUSC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg20476274 chr7:133979776 SLC35B4 0.86 16.25 0.66 3.8e-44 Mean platelet volume; LUSC cis rs4740619 0.967 rs7032755 chr9:15640025 G/T cg14451791 chr9:16040625 NA 0.31 5.75 0.3 2.03e-8 Body mass index; LUSC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg07777115 chr5:623756 CEP72 -0.47 -5.85 -0.3 1.18e-8 Obesity-related traits; LUSC cis rs1395 0.710 rs11674947 chr2:27471996 A/G cg23587288 chr2:27483067 SLC30A3 -0.3 -5.87 -0.31 1.04e-8 Blood metabolite levels; LUSC cis rs859767 0.501 rs6745983 chr2:135430709 C/T cg12500956 chr2:135428796 TMEM163 -0.29 -6.93 -0.35 2.13e-11 Neuroticism; LUSC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg05234568 chr11:5960015 NA -0.59 -8.49 -0.42 6.77e-16 DNA methylation (variation); LUSC cis rs17401966 0.838 rs4623 chr1:10366692 C/G cg19773385 chr1:10388646 KIF1B -0.5 -8.7 -0.43 1.56e-16 Hepatocellular carcinoma; LUSC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.16 -0.32 2.06e-9 Total body bone mineral density; LUSC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg19046167 chr17:80928561 B3GNTL1 0.43 6.36 0.33 6.54e-10 Breast cancer; LUSC cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg09085632 chr11:111637200 PPP2R1B 1.16 18.33 0.71 1.92e-52 Primary sclerosing cholangitis; LUSC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg22800045 chr5:56110881 MAP3K1 0.77 9.8 0.47 4.21e-20 Initial pursuit acceleration; LUSC cis rs11051970 0.879 rs1500874 chr12:32589407 G/A cg24626660 chr12:32551988 NA 0.33 5.66 0.3 3.2e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2692947 0.826 rs7423942 chr2:96645257 G/A cg23100626 chr2:96804247 ASTL 0.23 5.76 0.3 1.93e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs12908161 1.000 rs62019464 chr15:85294469 T/A cg17173187 chr15:85201210 NMB 0.5 9.39 0.46 9.83e-19 Schizophrenia; LUSC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg23283495 chr1:209979779 IRF6 0.64 9.36 0.46 1.21e-18 Cleft lip with or without cleft palate; LUSC cis rs66887589 0.776 rs10518337 chr4:120574874 A/C cg24375607 chr4:120327624 NA -0.46 -6.63 -0.34 1.38e-10 Diastolic blood pressure; LUSC cis rs3093024 0.595 rs4458654 chr6:167476068 A/C cg07741184 chr6:167504864 NA 0.49 8.55 0.42 4.42e-16 Rheumatoid arthritis; LUSC cis rs977987 0.843 rs67409275 chr16:75457212 T/C cg03315344 chr16:75512273 CHST6 0.54 10.32 0.49 7.18e-22 Dupuytren's disease; LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg18402987 chr7:1209562 NA 0.68 7.46 0.38 7.42e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9865818 0.702 rs2030520 chr3:188119582 C/T cg23651889 chr3:188115336 LPP -0.38 -5.96 -0.31 6.38e-9 Allergic sensitization; LUSC cis rs11190604 1.000 rs2298075 chr10:102247408 C/A cg16342193 chr10:102329863 NA -0.34 -6.2 -0.32 1.68e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg24375607 chr4:120327624 NA 0.78 11.7 0.54 9.85e-27 Corneal astigmatism; LUSC cis rs9807989 0.507 rs3732124 chr2:103018052 A/G cg03938978 chr2:103052716 IL18RAP -0.37 -7.02 -0.36 1.23e-11 Asthma; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg06873352 chr17:61820015 STRADA 0.69 11.49 0.53 5.84e-26 Prudent dietary pattern; LUSC cis rs1953600 0.870 rs2789695 chr10:81946840 C/T cg00277334 chr10:82204260 NA 0.45 7.08 0.36 8.35e-12 Sarcoidosis; LUSC trans rs61931739 0.635 rs7138254 chr12:33914422 G/T cg26384229 chr12:38710491 ALG10B 0.52 7.78 0.39 8.87e-14 Morning vs. evening chronotype; LUSC cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg12826209 chr6:26865740 GUSBL1 0.76 6.57 0.34 1.95e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs1814175 0.754 rs28663627 chr11:50048829 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs13256369 0.802 rs13280101 chr8:8562773 G/A cg06671706 chr8:8559999 CLDN23 0.49 6.52 0.34 2.66e-10 Obesity-related traits; LUSC cis rs3812111 0.510 rs6930059 chr6:116577623 T/C cg18828861 chr6:116576566 TSPYL4 0.38 6.75 0.35 6.41e-11 Age-related macular degeneration; LUSC trans rs61931739 0.614 rs6488172 chr12:33745669 A/G cg26384229 chr12:38710491 ALG10B 0.45 6.7 0.34 8.62e-11 Morning vs. evening chronotype; LUSC cis rs9473147 0.543 rs1872505 chr6:47480975 C/G cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC trans rs76248362 1.000 rs1886972 chr13:24436230 C/T cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs8062405 0.723 rs4788079 chr16:28559363 C/A cg07382826 chr16:28625726 SULT1A1 0.28 5.86 0.31 1.14e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg20503657 chr10:835505 NA 1.2 16.38 0.67 1.09e-44 Eosinophil percentage of granulocytes; LUSC cis rs11250098 0.574 rs7015168 chr8:10772210 G/C cg21775007 chr8:11205619 TDH -0.46 -6.32 -0.33 8.3e-10 Morning vs. evening chronotype; LUSC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg04450456 chr4:17643702 FAM184B 0.37 6.34 0.33 7.37e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg26924012 chr15:45694286 SPATA5L1 1.12 20.31 0.74 2.75e-60 Homoarginine levels; LUSC cis rs2762353 0.935 rs1165195 chr6:25815080 T/G cg03517284 chr6:25882590 NA -0.45 -8.13 -0.41 8.64e-15 Blood metabolite levels; LUSC cis rs459571 0.959 rs2810491 chr9:136923331 C/T cg01294253 chr9:136912663 BRD3 -0.33 -5.66 -0.3 3.27e-8 Platelet distribution width; LUSC cis rs5758659 0.652 rs133324 chr22:42406371 C/A cg04733989 chr22:42467013 NAGA 0.39 6.62 0.34 1.45e-10 Cognitive function; LUSC cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.85 0.54 2.87e-27 Personality dimensions; LUSC cis rs6977660 1.000 rs13231036 chr7:19806141 G/A cg05791153 chr7:19748676 TWISTNB 0.56 6.32 0.33 8.32e-10 Thyroid stimulating hormone; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg16705446 chr19:3751546 APBA3 -0.4 -6.22 -0.32 1.53e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg05340658 chr4:99064831 C4orf37 0.62 9.96 0.48 1.26e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4820539 1.000 rs916583 chr22:23469267 C/T cg21100191 chr22:23484243 RTDR1 0.91 15.8 0.65 2.24e-42 Bone mineral density; LUSC cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.41 0.49 3.7e-22 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11252926 0.563 rs10904173 chr10:462885 G/A cg16386425 chr10:429943 DIP2C 0.44 6.83 0.35 3.92e-11 Psychosis in Alzheimer's disease; LUSC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg10802521 chr3:52805072 NEK4 -0.52 -8.33 -0.41 2.19e-15 Intelligence (multi-trait analysis); LUSC trans rs6964492 0.576 rs2347716 chr7:134416085 G/A cg17334389 chr17:637070 FAM57A 0.26 5.98 0.31 5.72e-9 Tonsillectomy; LUSC cis rs6570726 0.935 rs413916 chr6:145831400 T/C cg05347473 chr6:146136440 FBXO30 0.45 7.69 0.39 1.63e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7100689 0.622 rs2342816 chr10:82086546 G/A cg00277334 chr10:82204260 NA -0.58 -8.71 -0.43 1.47e-16 Post bronchodilator FEV1; LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.95 0.31 6.78e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs12579753 0.913 rs7965664 chr12:82237340 G/T cg07923666 chr12:49932857 KCNH3 -0.54 -6.63 -0.34 1.38e-10 Resting heart rate; LUSC cis rs738321 0.794 rs5756940 chr22:38558842 C/T cg25457927 chr22:38595422 NA -0.37 -7.11 -0.36 7.05e-12 Breast cancer; LUSC cis rs6906287 0.647 rs7769001 chr6:118934509 A/G cg21191810 chr6:118973309 C6orf204 0.32 5.91 0.31 8.23e-9 Electrocardiographic conduction measures; LUSC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg21028142 chr17:79581711 NPLOC4 -0.32 -7.59 -0.38 3.25e-13 Eye color traits; LUSC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg27170947 chr2:26402098 FAM59B -0.66 -9.56 -0.46 2.57e-19 Gut microbiome composition (summer); LUSC cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg00852783 chr1:26633632 UBXN11 0.46 7.99 0.4 2.28e-14 Obesity-related traits; LUSC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg20243544 chr17:37824526 PNMT -0.49 -5.97 -0.31 5.91e-9 Glomerular filtration rate (creatinine); LUSC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.13 0.36 6.18e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9911578 0.967 rs6503890 chr17:57064167 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.98 0.31 5.65e-9 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.534 rs7138522 chr12:34039762 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 2.92e-25 Morning vs. evening chronotype; LUSC cis rs2250402 0.510 rs2291621 chr15:40324837 C/T cg10636054 chr15:40330586 SRP14 0.81 7.89 0.4 4.31e-14 Corneal curvature; LUSC cis rs11209002 0.956 rs2013772 chr1:67581445 A/T cg02640540 chr1:67518911 SLC35D1 0.69 7.58 0.38 3.42e-13 Crohn's disease; LUSC cis rs12210905 0.688 rs72845232 chr6:27428126 T/G cg08851530 chr6:28072375 NA 0.92 5.75 0.3 1.99e-8 Hip circumference adjusted for BMI; LUSC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs7917772 0.545 rs10786681 chr10:104317357 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.98 0.51 3.81e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs4650994 0.525 rs4076563 chr1:178516901 C/T cg05059571 chr16:84539110 KIAA1609 -0.47 -8.92 -0.44 3.21e-17 HDL cholesterol levels;HDL cholesterol; LUSC trans rs4332037 0.615 rs62435127 chr7:1884937 A/G cg25206134 chr2:45395956 NA 0.51 6.13 0.32 2.52e-9 Bipolar disorder; LUSC trans rs9929218 0.906 rs9932679 chr16:68751904 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -13.15 -0.58 4.02e-32 Colorectal cancer; LUSC cis rs10740039 0.883 rs7089287 chr10:62393764 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg21862992 chr11:68658383 NA 0.5 8.09 0.4 1.1e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7715806 0.500 rs72633982 chr5:75001321 C/T cg19683494 chr5:74908142 NA 0.57 7.71 0.39 1.43e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.71 0.34 8.57e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg17376030 chr22:41985996 PMM1 -0.47 -6.05 -0.31 3.85e-9 Vitiligo; LUSC cis rs2322633 0.515 rs1892474 chr6:80862349 G/A cg08355045 chr6:80787529 NA 0.4 6.73 0.35 7.3e-11 Height; LUSC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg03929089 chr4:120376271 NA -1.04 -19.98 -0.74 5.38e-59 Height; LUSC cis rs713587 0.646 rs2384061 chr2:25135620 C/T cg15423357 chr2:25149977 NA 0.37 7.36 0.37 1.41e-12 Body mass index in non-asthmatics; LUSC trans rs6499188 1.000 rs6499188 chr16:68674788 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 8.07 0.4 1.3e-14 Ulcerative colitis; LUSC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg12963246 chr6:28129442 ZNF389 0.48 6.73 0.35 7.46e-11 Depression; LUSC cis rs9300255 0.602 rs1106240 chr12:123626982 C/T cg13010344 chr12:123464640 ARL6IP4 -0.47 -5.88 -0.31 1e-8 Neutrophil percentage of white cells; LUSC cis rs3806843 0.966 rs3806842 chr5:140212676 C/T cg18004175 chr5:140027590 IK;NDUFA2 0.36 5.75 0.3 2.04e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.3 0.33 9.5e-10 Menopause (age at onset); LUSC cis rs1443512 0.796 rs1822437 chr12:54340077 A/G cg17410650 chr12:54324560 NA 0.62 10.37 0.49 5.11e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.06 -0.36 9.71e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs6982636 1.000 rs2001844 chr8:126478745 A/G cg13325919 chr3:181432053 SOX2;SOX2OT -0.34 -6.43 -0.33 4.44e-10 Lipid metabolism phenotypes; LUSC cis rs453301 0.597 rs7001187 chr8:8792782 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.51 -0.38 5.49e-13 Joint mobility (Beighton score); LUSC cis rs9914988 0.509 rs12453166 chr17:27298709 A/G cg10538030 chr17:27276405 PHF12 -0.56 -5.71 -0.3 2.55e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs908922 0.676 rs11205033 chr1:152527966 C/A cg20991723 chr1:152506922 NA 0.51 9.53 0.46 3.42e-19 Hair morphology; LUSC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.74 7.42 0.38 1e-12 Initial pursuit acceleration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11528995 chr1:117210575 IGSF3 -0.48 -6.4 -0.33 5.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg02475777 chr4:1388615 CRIPAK 0.39 5.75 0.3 2.07e-8 Longevity; LUSC cis rs6500395 1.000 rs4493038 chr16:48683920 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.84 0.35 3.77e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7772486 0.875 rs2207785 chr6:146332784 T/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.26 -0.37 2.81e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.955 rs1551 chr4:120158500 T/G cg24375607 chr4:120327624 NA 0.75 11.48 0.53 6.19e-26 Corneal astigmatism; LUSC cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg05082376 chr22:42548792 NA -0.4 -6.41 -0.33 4.97e-10 Schizophrenia; LUSC cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg06064525 chr11:970664 AP2A2 -0.49 -10.52 -0.5 1.46e-22 Alzheimer's disease (late onset); LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg19318889 chr4:1322082 MAEA -0.55 -9.03 -0.44 1.42e-17 Obesity-related traits; LUSC cis rs77633900 0.772 rs75253262 chr15:76657124 G/A cg21673338 chr15:77095150 SCAPER -0.72 -6.18 -0.32 1.91e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs9902453 0.838 rs3110495 chr17:27978455 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -9.66 -0.47 1.26e-19 Coffee consumption (cups per day); LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg16405210 chr4:1374714 KIAA1530 -0.54 -8.47 -0.42 8.13e-16 Obesity-related traits; LUSC cis rs6121246 0.559 rs6060599 chr20:30257754 T/G cg13852791 chr20:30311386 BCL2L1 0.96 14.98 0.63 3.5e-39 Mean corpuscular hemoglobin; LUSC trans rs744016 0.594 rs4822751 chr22:27009128 G/T cg24724084 chr15:48011382 SEMA6D -0.54 -6.03 -0.31 4.37e-9 RR interval (heart rate); LUSC cis rs694739 0.628 rs10897487 chr11:64140704 C/T cg02228329 chr11:64053129 BAD;GPR137 0.44 6.25 0.32 1.26e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs925255 0.711 rs12478126 chr2:28645948 C/T cg01273330 chr2:28605224 NA -0.37 -6.01 -0.31 4.88e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg13453750 chr1:205783389 SLC41A1 -0.3 -5.98 -0.31 5.73e-9 Menarche (age at onset); LUSC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.95 0.48 1.35e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7904368 0.568 rs10752061 chr10:16853900 A/G cg23933602 chr10:16859644 RSU1 0.7 11.61 0.54 2.08e-26 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg03929089 chr4:120376271 NA -1.03 -19.84 -0.74 2.02e-58 Height; LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg26446133 chr18:72167187 CNDP2 -0.79 -10.87 -0.51 9.06e-24 Refractive error; LUSC cis rs7647973 0.769 rs7434187 chr3:49032967 C/T cg21141812 chr3:48556323 PFKFB4 0.35 6.07 0.32 3.42e-9 Menarche (age at onset); LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg14159672 chr1:205819179 PM20D1 0.8 13.62 0.6 6.42e-34 Menarche (age at onset); LUSC cis rs2637266 0.967 rs4581393 chr10:78376123 A/C cg18941641 chr10:78392320 NA 0.38 6.94 0.36 2.04e-11 Pulmonary function; LUSC cis rs66887589 0.934 rs6817317 chr4:120542827 A/G cg09307838 chr4:120376055 NA -0.49 -7.48 -0.38 6.81e-13 Diastolic blood pressure; LUSC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg04455712 chr21:45112962 RRP1B 0.47 8.99 0.44 1.9e-17 Mean corpuscular volume; LUSC cis rs10489202 1.000 rs12407660 chr1:167954363 C/T cg24449463 chr1:168025552 DCAF6 -0.58 -7.37 -0.37 1.32e-12 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21039822 chr17:79869136 PCYT2 0.5 6.92 0.35 2.35e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg12257692 chr3:49977190 RBM6 -0.24 -6.68 -0.34 1.01e-10 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.706 rs590051 chr17:37446571 T/C cg07936489 chr17:37558343 FBXL20 0.78 9.96 0.48 1.27e-20 Glomerular filtration rate (creatinine); LUSC cis rs921665 0.831 rs6548168 chr2:3181784 T/C cg16434511 chr2:3151078 NA -0.61 -6.89 -0.35 2.74e-11 World class endurance athleticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25140945 chr1:3816479 C1orf174;LOC100133612 0.46 6.48 0.33 3.38e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg11752832 chr7:134001865 SLC35B4 0.54 8.13 0.41 8.64e-15 Mean platelet volume; LUSC cis rs56283067 0.578 rs12197755 chr6:45387495 T/G cg20913747 chr6:44695427 NA -0.42 -6.02 -0.31 4.61e-9 Total body bone mineral density; LUSC cis rs10782582 0.617 rs1846233 chr1:76159354 C/T cg22875332 chr1:76189707 ACADM -0.42 -6.22 -0.32 1.48e-9 Daytime sleep phenotypes; LUSC cis rs6918586 0.658 rs198814 chr6:26127759 A/G cg17691542 chr6:26056736 HIST1H1C 0.4 5.95 0.31 6.7e-9 Schizophrenia; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg16145915 chr7:1198662 ZFAND2A -0.59 -11.05 -0.52 2.07e-24 Longevity;Endometriosis; LUSC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.57 -0.38 3.64e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg22903471 chr2:27725779 GCKR -0.4 -6.84 -0.35 3.67e-11 Total body bone mineral density; LUSC cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.51 -0.38 5.54e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs950776 0.506 rs12915366 chr15:78831753 G/A cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02984193 chr15:91260561 BLM -0.46 -6.2 -0.32 1.71e-9 Bipolar disorder and schizophrenia; LUSC cis rs6424115 1.000 rs7515969 chr1:24158398 G/A cg10978503 chr1:24200527 CNR2 -0.51 -11.96 -0.55 1.15e-27 Immature fraction of reticulocytes; LUSC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.45 -8.14 -0.41 7.93e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg12288994 chr5:1860383 NA 0.3 6.95 0.36 1.93e-11 Cardiovascular disease risk factors; LUSC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg18351406 chr4:77819688 ANKRD56 0.58 8.49 0.42 7.11e-16 Emphysema distribution in smoking; LUSC trans rs877282 0.898 rs11253343 chr10:765117 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs9611565 0.649 rs4822050 chr22:42177453 C/G cg17376030 chr22:41985996 PMM1 0.46 6.35 0.33 6.91e-10 Vitiligo; LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg26304593 chr6:42947056 PEX6 -0.52 -7.95 -0.4 2.96e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9527 0.590 rs3740386 chr10:104931051 C/T cg05855489 chr10:104503620 C10orf26 0.52 7.88 0.4 4.72e-14 Arsenic metabolism; LUSC cis rs77633900 0.772 rs182253 chr15:76800755 C/T cg21673338 chr15:77095150 SCAPER -0.69 -5.89 -0.31 9.57e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.36 0.49 5.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7216064 1.000 rs9912084 chr17:65868035 A/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6840360 0.642 rs1443089 chr4:152450300 A/G cg20465933 chr4:152376761 FAM160A1 0.33 5.94 0.31 7.18e-9 Intelligence (multi-trait analysis); LUSC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.06e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11098499 0.739 rs10031033 chr4:120151452 C/T cg24375607 chr4:120327624 NA 0.66 11.07 0.52 1.72e-24 Corneal astigmatism; LUSC cis rs1172822 0.828 rs11668309 chr19:55833460 A/G cg04391588 chr19:55832610 TMEM150B -0.3 -5.66 -0.3 3.22e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs1267303 0.642 rs6670699 chr1:46997270 C/T cg25110126 chr1:46999211 NA 0.77 10.91 0.51 6.86e-24 Monobrow; LUSC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg10523679 chr1:76189770 ACADM 0.83 12.78 0.57 9.76e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg08645402 chr16:4508243 NA -0.47 -7.51 -0.38 5.49e-13 Schizophrenia; LUSC cis rs1018836 0.923 rs4734266 chr8:91628147 C/T cg16814680 chr8:91681699 NA -0.77 -12.95 -0.58 2.23e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9837602 0.938 rs10511177 chr3:99724873 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.22 -0.32 1.52e-9 Breast cancer; LUSC cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg02423579 chr7:2872169 GNA12 0.42 6.56 0.34 2.07e-10 Height; LUSC cis rs7940866 0.874 rs11222406 chr11:130814093 A/G cg12179176 chr11:130786555 SNX19 0.62 9.24 0.45 3.04e-18 Schizophrenia; LUSC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg20203395 chr5:56204925 C5orf35 -0.73 -9.9 -0.48 1.9e-20 Initial pursuit acceleration; LUSC cis rs12701220 0.690 rs10243973 chr7:1064983 T/C cg23978390 chr7:1156363 C7orf50 0.47 5.77 0.3 1.8e-8 Bronchopulmonary dysplasia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22075671 chr5:133747798 CDKN2AIPNL -0.4 -5.96 -0.31 6.35e-9 Hepatitis; LUSC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.59 8.63 0.43 2.55e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2070433 0.660 rs11701034 chr21:47793235 A/G cg12379764 chr21:47803548 PCNT 0.77 9.7 0.47 9.2e-20 Lymphocyte counts; LUSC cis rs3813567 0.759 rs12595350 chr15:78953464 G/A cg04896959 chr15:78267971 NA -0.45 -7.12 -0.36 6.62e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg02782426 chr3:40428986 ENTPD3 0.41 7.77 0.39 9.59e-14 Renal cell carcinoma; LUSC cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg06634786 chr22:41940651 POLR3H -0.49 -5.75 -0.3 2e-8 Vitiligo; LUSC cis rs7575873 1 rs7575873 chr2:23962647 A/G cg08917208 chr2:24149416 ATAD2B 0.98 9.95 0.48 1.34e-20 Birth weight; LUSC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.15 0.41 7.33e-15 Homoarginine levels; LUSC cis rs6665290 0.935 rs12409755 chr1:227196949 A/T cg10327440 chr1:227177885 CDC42BPA -1.22 -39.91 -0.91 3.76e-129 Myeloid white cell count; LUSC cis rs2688608 0.967 rs2675663 chr10:75660270 T/G cg17411546 chr10:75410026 SYNPO2L -0.43 -6.29 -0.33 9.7e-10 Inflammatory bowel disease; LUSC cis rs11690935 0.959 rs10497374 chr2:172640623 A/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -15.3 -0.64 2.02e-40 Schizophrenia; LUSC cis rs1535500 1.000 rs35099099 chr6:39284857 G/A cg06347083 chr6:39282316 KCNK17 -0.27 -5.81 -0.3 1.43e-8 Type 2 diabetes; LUSC cis rs4713675 0.546 rs2296739 chr6:33656969 G/A cg14003231 chr6:33640908 ITPR3 0.33 6.23 0.32 1.44e-9 Plateletcrit; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg11235426 chr6:292522 DUSP22 -0.66 -10.46 -0.5 2.45e-22 Menopause (age at onset); LUSC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.92 13.28 0.59 1.37e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6120849 0.754 rs1885117 chr20:33600740 C/T cg24642439 chr20:33292090 TP53INP2 0.6 6.67 0.34 1.05e-10 Protein C levels; LUSC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.9 -0.55 1.77e-27 Extrinsic epigenetic age acceleration; LUSC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg03611598 chr17:48586076 MYCBPAP -0.62 -8.74 -0.43 1.13e-16 Visceral fat; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13329889 chr7:5705264 RNF216 0.41 6.68 0.34 9.8e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7618501 0.571 rs2240329 chr3:50107512 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.24 -0.45 2.91e-18 Intelligence (multi-trait analysis); LUSC trans rs62238980 0.614 rs80272272 chr22:32475924 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs921968 0.678 rs500422 chr2:219432995 C/A cg02176678 chr2:219576539 TTLL4 0.61 10.83 0.51 1.25e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs929354 0.713 rs7798816 chr7:156940574 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6500602 1.000 rs11647946 chr16:4462836 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.46 5.94 0.31 6.99e-9 Schizophrenia; LUSC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg18404041 chr3:52824283 ITIH1 -0.52 -9.81 -0.47 4.05e-20 Intelligence (multi-trait analysis); LUSC trans rs1973993 0.691 rs6658131 chr1:96889314 C/T cg10631902 chr5:14652156 NA 0.58 10.54 0.5 1.25e-22 Weight; LUSC cis rs1801251 1.000 rs283479 chr2:233648754 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.16 0.32 2.14e-9 Coronary artery disease; LUSC cis rs12618769 0.543 rs56357378 chr2:99032455 T/G cg10123293 chr2:99228465 UNC50 0.48 8.19 0.41 5.54e-15 Bipolar disorder; LUSC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg18252515 chr7:66147081 NA -1.22 -13.35 -0.59 7.04e-33 Diabetic kidney disease; LUSC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg26597838 chr10:835615 NA 1.01 14.16 0.61 5.63e-36 Eosinophil percentage of granulocytes; LUSC cis rs10876993 0.680 rs2277322 chr12:58009202 T/C cg18357645 chr12:58087776 OS9 -0.5 -7.52 -0.38 5.14e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 11.54 0.53 3.72e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11992162 0.636 rs4841645 chr8:11798684 G/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.19 -0.32 1.79e-9 Monocyte count; LUSC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.590 rs7912517 chr10:104905529 G/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.35 -0.33 7.16e-10 Arsenic metabolism; LUSC trans rs62238980 0.614 rs78781151 chr22:32375462 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs10203711 1.000 rs12692240 chr2:239558688 A/G cg14580085 chr2:239553406 NA 0.4 6.8 0.35 4.78e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs12908161 1.000 rs58416181 chr15:85264461 G/A cg17173187 chr15:85201210 NMB 0.51 9.61 0.47 1.88e-19 Schizophrenia; LUSC trans rs7769051 1.000 rs6934161 chr6:133124077 C/T cg27275811 chr11:74457193 NA 0.63 6.14 0.32 2.33e-9 Type 2 diabetes nephropathy; LUSC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg24675056 chr1:15929824 NA 0.47 8.02 0.4 1.75e-14 Systolic blood pressure; LUSC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg20933634 chr6:27740509 NA 0.4 5.7 0.3 2.6e-8 Parkinson's disease; LUSC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg03563238 chr19:33554763 RHPN2 -0.33 -5.74 -0.3 2.14e-8 Colorectal cancer; LUSC cis rs6121246 0.529 rs6058196 chr20:30194714 A/T cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg09955084 chr16:413813 NA 0.26 5.77 0.3 1.83e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs1419980 0.630 rs2080126 chr12:7774524 A/C cg10578777 chr12:7781093 NA 0.59 6.47 0.33 3.44e-10 HDL cholesterol levels; LUSC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg02038168 chr22:39784481 NA -0.48 -7.72 -0.39 1.35e-13 Intelligence (multi-trait analysis); LUSC cis rs713477 0.692 rs10146713 chr14:55911597 T/C cg13175173 chr14:55914753 NA -0.3 -6.06 -0.31 3.59e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg16386425 chr10:429943 DIP2C -0.39 -6.13 -0.32 2.42e-9 Psychosis in Alzheimer's disease; LUSC cis rs9486719 1.000 rs12190507 chr6:96898265 T/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs7291412 0.929 rs7289457 chr22:46456603 C/T cg00785112 chr22:46450059 C22orf26;LOC150381 0.46 7.3 0.37 2.13e-12 Dupuytren's disease;Subjective well-being; LUSC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs10511400 0.764 rs9811483 chr3:119936972 G/A cg02809009 chr19:50354510 PTOV1 -0.69 -5.99 -0.31 5.46e-9 Economic and political preferences (feminism/equality); LUSC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg11244672 chr19:19639970 YJEFN3 -0.38 -5.75 -0.3 1.98e-8 Tonsillectomy; LUSC cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg16989719 chr2:238392110 NA -0.41 -7.04 -0.36 1.1e-11 Prostate cancer; LUSC cis rs7647973 0.626 rs1078341 chr3:49685592 A/G cg03060546 chr3:49711283 APEH 0.64 7.68 0.39 1.82e-13 Menarche (age at onset); LUSC cis rs7100689 0.725 rs2185425 chr10:82139941 T/C cg01528321 chr10:82214614 TSPAN14 1.03 16.08 0.66 1.68e-43 Post bronchodilator FEV1; LUSC cis rs62400317 0.762 rs12190313 chr6:44903902 T/G cg18551225 chr6:44695536 NA -0.48 -7.69 -0.39 1.68e-13 Total body bone mineral density; LUSC cis rs8060686 0.641 rs28508024 chr16:68126606 T/C cg26727032 chr16:67993705 SLC12A4 -0.42 -5.79 -0.3 1.62e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.46e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg22903471 chr2:27725779 GCKR -0.41 -6.89 -0.35 2.75e-11 Total body bone mineral density; LUSC cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.78 0.51 1.89e-23 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs28624237 chr12:34457171 G/T cg26384229 chr12:38710491 ALG10B 0.9 15.74 0.65 3.85e-42 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.78 0.3 1.74e-8 Menopause (age at onset); LUSC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg04369109 chr6:150039330 LATS1 -0.53 -7.57 -0.38 3.78e-13 Lung cancer; LUSC cis rs4654899 0.865 rs12123300 chr1:21323568 T/C cg01072550 chr1:21505969 NA -0.54 -7.97 -0.4 2.5e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1670533 1.000 rs11735663 chr4:1051845 C/T cg16405210 chr4:1374714 KIAA1530 -0.47 -5.78 -0.3 1.73e-8 Recombination rate (females); LUSC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg04315214 chr1:2043799 PRKCZ 0.48 10.16 0.49 2.65e-21 Height; LUSC cis rs9905704 0.918 rs12952362 chr17:56900870 A/G cg12560992 chr17:57184187 TRIM37 0.57 8.05 0.4 1.47e-14 Testicular germ cell tumor; LUSC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg23262073 chr20:60523788 NA -0.43 -6.29 -0.33 1e-9 Body mass index; LUSC cis rs61990749 0.597 rs4632066 chr14:78247282 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.62 -6.76 -0.35 6.19e-11 Fibroblast growth factor basic levels; LUSC cis rs8092503 1.000 rs12454336 chr18:52497204 C/T cg12377874 chr18:52495404 RAB27B -0.34 -6.27 -0.32 1.14e-9 Childhood body mass index; LUSC cis rs3806843 0.547 rs246065 chr5:140323638 A/G cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.51e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg18240062 chr17:79603768 NPLOC4 0.79 15.32 0.64 1.65e-40 Eye color traits; LUSC cis rs6121246 0.697 rs45557936 chr20:30226690 G/A cg21427119 chr20:30132790 HM13 -0.42 -6.27 -0.32 1.1e-9 Mean corpuscular hemoglobin; LUSC cis rs9682041 0.877 rs10804841 chr3:170072031 T/A cg11886554 chr3:170076028 SKIL 0.7 8.59 0.43 3.46e-16 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs11997175 0.838 rs10954934 chr8:33669637 T/C ch.8.33884649F chr8:33765107 NA 0.47 7.22 0.37 3.55e-12 Body mass index; LUSC cis rs8114671 0.562 rs2223881 chr20:33506463 A/C cg08999081 chr20:33150536 PIGU 0.32 5.65 0.3 3.51e-8 Height; LUSC cis rs381815 1.000 rs381815 chr11:16902268 C/T cg05701403 chr11:16947551 PLEKHA7 0.38 5.77 0.3 1.78e-8 Diastolic blood pressure;Systolic blood pressure;Blood pressure; LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg08677398 chr8:58056175 NA 0.58 7.01 0.36 1.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg15556689 chr8:8085844 FLJ10661 -0.61 -9.55 -0.46 2.94e-19 Joint mobility (Beighton score); LUSC cis rs6456156 0.774 rs6930998 chr6:167526940 A/C cg07741184 chr6:167504864 NA -0.35 -6.14 -0.32 2.36e-9 Primary biliary cholangitis; LUSC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg11764359 chr7:65958608 NA 0.51 6.67 0.34 1.08e-10 Aortic root size; LUSC cis rs861020 0.630 rs627069 chr1:210004613 C/G cg05527609 chr1:210001259 C1orf107 0.7 10.07 0.48 5.22e-21 Orofacial clefts; LUSC cis rs9394152 0.845 rs9296092 chr6:33478496 C/T cg13560919 chr6:33536144 NA -0.58 -10.53 -0.5 1.45e-22 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7208859 0.623 rs7503542 chr17:29073830 A/C cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs79149102 0.579 rs79916508 chr15:75373721 A/C cg09165964 chr15:75287851 SCAMP5 -0.73 -6.73 -0.35 7.21e-11 Lung cancer; LUSC cis rs2073300 0.609 rs6137927 chr20:23372513 A/G cg12062639 chr20:23401060 NAPB 0.93 8.06 0.4 1.33e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg18512352 chr11:47633146 NA -0.46 -9.28 -0.45 2.25e-18 Subjective well-being; LUSC cis rs10736390 1.000 rs10736390 chr1:55103945 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.64 -12.18 -0.55 1.66e-28 Survival in pancreatic cancer; LUSC cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg05347473 chr6:146136440 FBXO30 0.45 7.69 0.39 1.66e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7917772 0.545 rs3934960 chr10:104355275 A/G cg05855489 chr10:104503620 C10orf26 0.49 7.52 0.38 4.99e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs3857536 0.776 rs4710316 chr6:66935097 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs8060686 0.641 rs73612690 chr16:68153200 G/A cg27539214 chr16:67997921 SLC12A4 -0.54 -7.27 -0.37 2.56e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs10992471 0.603 rs4743873 chr9:95270781 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.39 6.76 0.35 6.22e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs1325195 0.881 rs3813642 chr1:179070120 C/T cg11624085 chr17:8464688 MYH10 -0.42 -6.9 -0.35 2.57e-11 IgE grass sensitization; LUSC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg00149659 chr3:10157352 C3orf10 -0.96 -14.29 -0.62 1.78e-36 Alzheimer's disease; LUSC trans rs2363709 0.892 rs9832987 chr3:67418396 C/A cg23062198 chr2:14774063 FAM84A -0.54 -5.98 -0.31 5.77e-9 IgE levels; LUSC cis rs9653442 0.545 rs11681227 chr2:100754997 A/G cg22139774 chr2:100720529 AFF3 -0.43 -7.29 -0.37 2.3e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9325144 0.625 rs11534879 chr12:38968165 A/G cg13010199 chr12:38710504 ALG10B -0.53 -8.19 -0.41 5.44e-15 Morning vs. evening chronotype; LUSC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg05623727 chr3:50126028 RBM5 -0.32 -5.96 -0.31 6.34e-9 Intelligence (multi-trait analysis); LUSC cis rs5769707 0.521 rs7285764 chr22:50058561 T/C cg05373962 chr22:49881684 NA -0.4 -8.46 -0.42 8.69e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs13082711 0.911 rs3755652 chr3:27472936 A/G cg02860705 chr3:27208620 NA -0.47 -7.61 -0.38 2.9e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs77633900 0.772 rs4886491 chr15:76661925 C/T cg21673338 chr15:77095150 SCAPER -0.65 -5.8 -0.3 1.53e-8 Non-glioblastoma glioma;Glioma; LUSC cis rs734999 0.545 rs7368105 chr1:2556548 C/T cg18854424 chr1:2615690 NA 0.5 10.01 0.48 8.46e-21 Ulcerative colitis; LUSC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg05535760 chr7:792225 HEATR2 0.91 9.61 0.47 1.88e-19 Cerebrospinal P-tau181p levels; LUSC cis rs8180040 0.966 rs3816779 chr3:47543389 C/T cg27129171 chr3:47204927 SETD2 0.68 11.47 0.53 6.92e-26 Colorectal cancer; LUSC cis rs7000551 0.689 rs10110254 chr8:22309551 G/T cg12081754 chr8:22256438 SLC39A14 0.49 7.54 0.38 4.34e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11630290 0.518 rs56247655 chr15:64171627 G/A cg12036633 chr15:63758958 NA -0.56 -6.59 -0.34 1.75e-10 Iris characteristics; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg06383048 chr11:118401878 TMEM25 0.39 6.02 0.31 4.65e-9 Schizophrenia; LUSC trans rs7819412 0.505 rs17782536 chr8:11021682 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.08 -0.36 8.49e-12 Triglycerides; LUSC cis rs425277 0.958 rs262660 chr1:2086757 A/G cg24578937 chr1:2090814 PRKCZ 0.61 13.92 0.61 4.89e-35 Height; LUSC cis rs7927592 0.871 rs17603185 chr11:68376241 C/T cg20283391 chr11:68216788 NA -0.6 -8.37 -0.42 1.6e-15 Total body bone mineral density; LUSC cis rs73198271 0.562 rs73519953 chr8:8660278 G/T cg01851573 chr8:8652454 MFHAS1 0.64 8.88 0.44 4.33e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs877282 0.786 rs10904558 chr10:797509 C/T cg13042288 chr15:90349979 ANPEP -0.5 -7.47 -0.38 7.3e-13 Uric acid levels; LUSC cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg16414030 chr3:133502952 NA 0.42 6.39 0.33 5.67e-10 Iron status biomarkers; LUSC cis rs17253792 0.822 rs80174205 chr14:56058694 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs7819412 0.595 rs10503416 chr8:10987553 C/T cg21775007 chr8:11205619 TDH 0.54 7.77 0.39 9.57e-14 Triglycerides; LUSC cis rs7833790 0.777 rs10958042 chr8:82678393 G/T cg27398817 chr8:82754497 SNX16 -0.65 -8.05 -0.4 1.43e-14 Diastolic blood pressure; LUSC cis rs16854884 0.538 rs61359084 chr3:143738362 T/C cg06585982 chr3:143692056 C3orf58 0.51 8.06 0.4 1.33e-14 Economic and political preferences (feminism/equality); LUSC cis rs2235544 0.542 rs585269 chr1:54469976 C/T cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg00484396 chr16:3507460 NAT15 0.73 12.48 0.56 1.34e-29 Tuberculosis; LUSC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -6.43 -0.33 4.33e-10 Neutrophil percentage of white cells; LUSC cis rs1775715 0.707 rs2808088 chr10:32146150 A/G cg18675610 chr10:32216311 ARHGAP12 0.31 6.87 0.35 3.21e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.68 -10.23 -0.49 1.51e-21 Monocyte percentage of white cells; LUSC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg04553112 chr3:125709451 NA -0.5 -5.66 -0.3 3.27e-8 Blood pressure (smoking interaction); LUSC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg22834771 chr12:69754056 YEATS4 -0.49 -7.41 -0.38 1.02e-12 Blood protein levels; LUSC cis rs1215050 0.791 rs783969 chr4:98906504 C/T cg05340658 chr4:99064831 C4orf37 0.41 6.42 0.33 4.64e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1728785 1.000 rs1749793 chr16:68569312 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.75 -0.3 2e-8 Ulcerative colitis; LUSC trans rs61931739 0.500 rs10844846 chr12:34394611 C/G cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.35e-33 Morning vs. evening chronotype; LUSC cis rs6840360 0.967 rs6832562 chr4:152602798 A/G cg22705602 chr4:152727874 NA -0.27 -5.72 -0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg18876405 chr7:65276391 NA -0.55 -8.79 -0.43 8.32e-17 Aortic root size; LUSC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg09021430 chr5:549028 NA -0.57 -8.38 -0.42 1.51e-15 Obesity-related traits; LUSC cis rs2840044 1.000 rs9891800 chr17:33895015 G/C cg05299278 chr17:33885742 SLFN14 -0.31 -6.38 -0.33 5.92e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs501916 0.634 rs531596 chr15:48058214 C/T cg16110827 chr15:48056943 SEMA6D -0.38 -5.9 -0.31 8.75e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs1801251 0.752 rs2675966 chr2:233735543 T/C cg25237894 chr2:233734115 C2orf82 -0.35 -6.57 -0.34 1.97e-10 Coronary artery disease; LUSC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg05368731 chr17:41323189 NBR1 0.82 13.29 0.59 1.16e-32 Menopause (age at onset); LUSC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg25258033 chr6:167368657 RNASET2 0.44 7.05 0.36 1.02e-11 Crohn's disease; LUSC cis rs7829975 0.509 rs7838674 chr8:8797073 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.59 -0.43 3.43e-16 Mood instability; LUSC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg20573242 chr4:122745356 CCNA2 0.45 6.89 0.35 2.72e-11 Type 2 diabetes; LUSC cis rs11158026 0.757 rs7146285 chr14:55412869 T/C cg04306507 chr14:55594613 LGALS3 0.34 6.37 0.33 6.1e-10 Parkinson's disease; LUSC cis rs12532214 1.000 rs12532214 chr7:3169890 C/G cg19214707 chr7:3157722 NA -0.4 -6.31 -0.33 8.95e-10 Itch intensity from mosquito bite; LUSC cis rs2439831 1.000 rs2467743 chr15:43750346 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs2439831 0.571 rs689883 chr15:43812596 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.86 9.57 0.46 2.52e-19 Lung cancer in ever smokers; LUSC cis rs7584330 0.554 rs13395743 chr2:238437554 C/T cg14458575 chr2:238380390 NA 0.46 5.79 0.3 1.6e-8 Prostate cancer; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg23978390 chr7:1156363 C7orf50 0.5 7.06 0.36 9.93e-12 Longevity;Endometriosis; LUSC cis rs4631830 0.863 rs3101227 chr10:51520203 C/A cg16070123 chr10:51489643 NA -0.5 -7.91 -0.4 3.72e-14 Prostate-specific antigen levels; LUSC cis rs2979489 0.945 rs17627903 chr8:30351812 T/C cg26383811 chr8:30366931 RBPMS -0.55 -8.58 -0.42 3.73e-16 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs1941023 0.584 rs10897057 chr11:60172273 A/T cg08716584 chr11:60157161 MS4A7 -0.62 -11.34 -0.53 2.02e-25 Congenital heart disease (maternal effect); LUSC cis rs826838 0.868 rs864324 chr12:39122853 A/G cg13010199 chr12:38710504 ALG10B 0.55 9.23 0.45 3.1e-18 Heart rate; LUSC cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg11057378 chr10:81107060 PPIF 0.39 6.36 0.33 6.81e-10 Height; LUSC trans rs61931739 1.000 rs11052989 chr12:34057614 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.78 -0.39 9.18e-14 Morning vs. evening chronotype; LUSC cis rs9399135 1.000 rs1014021 chr6:135334600 C/T cg22676075 chr6:135203613 NA -0.48 -7.58 -0.38 3.38e-13 Red blood cell count; LUSC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg00033643 chr7:134001901 SLC35B4 0.45 7.09 0.36 7.88e-12 Mean platelet volume; LUSC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg15320075 chr8:145703422 NA 0.65 11.41 0.53 1.07e-25 Age at first birth; LUSC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.84 -0.3 1.21e-8 Neutrophil percentage of white cells; LUSC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs6681460 1.000 rs10889641 chr1:67138367 C/T cg02459107 chr1:67143332 SGIP1 0.49 9.11 0.45 7.64e-18 Presence of antiphospholipid antibodies; LUSC cis rs6977660 0.562 rs2189566 chr7:19768960 G/A cg07541023 chr7:19748670 TWISTNB 0.81 8.41 0.42 1.19e-15 Thyroid stimulating hormone; LUSC trans rs2786098 0.616 rs10801614 chr1:197520273 T/C cg16005942 chr6:160526640 IGF2R -0.5 -6.23 -0.32 1.4e-9 Asthma; LUSC cis rs61931739 0.534 rs1705757 chr12:34091637 A/G cg06521331 chr12:34319734 NA -0.52 -8.62 -0.43 2.69e-16 Morning vs. evening chronotype; LUSC cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg06550200 chr5:1325588 CLPTM1L -0.66 -11.17 -0.52 8.07e-25 Lung cancer; LUSC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.87 14.63 0.62 8.8e-38 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9457247 0.967 rs387733 chr6:167409771 C/T cg23791538 chr6:167370224 RNASET2 0.44 7.1 0.36 7.43e-12 Crohn's disease; LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg01427869 chr13:113580562 NA 0.57 6.35 0.33 6.97e-10 Schizophrenia; LUSC cis rs12940923 1.000 rs35444528 chr17:56367065 A/C cg19466818 chr17:56409534 MIR142 -0.39 -6.87 -0.35 3.19e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs3736594 0.513 rs6751087 chr2:27778016 T/C cg27432699 chr2:27873401 GPN1 0.67 8.9 0.44 3.75e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs12980942 0.630 rs7257825 chr19:41788344 T/C cg25627403 chr19:41769009 HNRNPUL1 0.59 6.49 0.33 3.13e-10 Coronary artery disease; LUSC cis rs965469 0.895 rs6037595 chr20:3401128 T/G cg25506879 chr20:3388711 C20orf194 -0.54 -6.14 -0.32 2.29e-9 IFN-related cytopenia; LUSC cis rs59104589 0.617 rs3755395 chr2:242294116 A/G cg14842376 chr2:242211374 HDLBP 0.63 6.88 0.35 2.97e-11 Fibrinogen levels; LUSC cis rs9527 0.615 rs10883781 chr10:104581130 A/G cg05855489 chr10:104503620 C10orf26 0.69 10.01 0.48 8.35e-21 Arsenic metabolism; LUSC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.83 12.43 0.56 2.1e-29 Cognitive test performance; LUSC cis rs2692947 0.683 rs1813381 chr2:96422939 C/T cg23100626 chr2:96804247 ASTL -0.29 -6.58 -0.34 1.77e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg06600287 chr1:53387719 ECHDC2 -0.27 -5.81 -0.3 1.49e-8 Monocyte count; LUSC cis rs4964805 0.632 rs11111782 chr12:104188476 A/G cg02344784 chr12:104178138 NT5DC3 -0.45 -8.52 -0.42 5.53e-16 Attention deficit hyperactivity disorder; LUSC trans rs9944275 0.860 rs36094086 chr15:97192674 A/G cg18834029 chr10:103349097 POLL;RP11-529I10.4 -0.6 -5.97 -0.31 6.23e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); LUSC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.89 12.61 0.57 4.5e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6840360 0.615 rs4696290 chr4:152631472 A/G cg22705602 chr4:152727874 NA -0.33 -7.16 -0.36 5.22e-12 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 6.97 0.36 1.66e-11 Platelet count; LUSC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg23719950 chr11:63933701 MACROD1 -0.61 -7.99 -0.4 2.22e-14 Mean platelet volume; LUSC trans rs629535 0.911 rs688612 chr8:70011887 C/T cg21567404 chr3:27674614 NA -0.95 -15.08 -0.64 1.48e-39 Dupuytren's disease; LUSC cis rs3820068 0.608 rs2057304 chr1:16017710 A/G cg24675056 chr1:15929824 NA 0.41 6.84 0.35 3.9e-11 Systolic blood pressure; LUSC cis rs7267979 0.966 rs2424714 chr20:25418681 T/G cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs477692 1.000 rs553371 chr10:131413676 T/C cg11019008 chr10:131425282 MGMT 0.42 6.34 0.33 7.48e-10 Response to temozolomide; LUSC cis rs6835098 1.000 rs10011724 chr4:174088865 A/G cg08422745 chr4:174089978 GALNT7 -0.82 -13.63 -0.6 6.05e-34 Dementia and core Alzheimer's disease neuropathologic changes; LUSC trans rs877282 1.000 rs112522746 chr10:772288 T/C cg22713356 chr15:30763199 NA 1.09 15.15 0.64 7.93e-40 Uric acid levels; LUSC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg18131467 chr2:239335373 ASB1 1.04 25.08 0.81 8.88e-79 Multiple system atrophy; LUSC cis rs7945718 0.967 rs7931147 chr11:12748884 C/A cg25843174 chr11:12811716 TEAD1 0.33 7.32 0.37 1.91e-12 Educational attainment (years of education); LUSC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.96 18.63 0.71 1.33e-53 Body mass index (adult); LUSC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg05347473 chr6:146136440 FBXO30 -0.57 -9.71 -0.47 8.71e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg06640241 chr16:89574553 SPG7 0.66 9.82 0.47 3.8e-20 Multiple myeloma (IgH translocation); LUSC cis rs10979 1.000 rs9496673 chr6:143885393 C/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.02 -0.55 6.53e-28 Hypospadias; LUSC cis rs13385 0.769 rs7707814 chr5:139583728 C/G cg26211634 chr5:139558579 C5orf32 0.44 6.59 0.34 1.76e-10 Atrial fibrillation; LUSC trans rs1998174 0.509 rs4916402 chr1:171815948 C/T cg13482142 chr2:234261155 NA 0.41 6.05 0.31 3.83e-9 Platelet distribution width; LUSC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg06212747 chr3:49208901 KLHDC8B 0.45 5.89 0.31 9.48e-9 Parkinson's disease; LUSC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 19.8 0.73 2.9e-58 Homoarginine levels; LUSC cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg15691649 chr6:25882328 NA -0.39 -6.37 -0.33 6.27e-10 Blood metabolite levels; LUSC trans rs61931739 0.500 rs34287388 chr12:34444626 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.75 0.65 3.58e-42 Morning vs. evening chronotype; LUSC cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg20908204 chr19:46285434 DMPK -0.45 -8.45 -0.42 9.12e-16 Coronary artery disease; LUSC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg20243544 chr17:37824526 PNMT 0.39 5.96 0.31 6.59e-9 Self-reported allergy; LUSC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.25e-21 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg13206674 chr6:150067644 NUP43 0.6 9.67 0.47 1.15e-19 Lung cancer; LUSC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg20135002 chr11:47629003 NA -0.48 -7.52 -0.38 5.13e-13 Subjective well-being; LUSC cis rs9326248 0.581 rs12225187 chr11:116793231 G/A cg11861562 chr11:117069780 TAGLN 0.34 6.61 0.34 1.5e-10 Blood protein levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04590956 chr2:70057467 GMCL1 0.52 7.75 0.39 1.09e-13 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10876993 0.890 rs799575 chr12:58069107 A/G cg18357645 chr12:58087776 OS9 0.54 8.3 0.41 2.58e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs13631 0.894 rs7856589 chr9:140003921 A/G cg14289826 chr9:140003911 NA -0.35 -6.99 -0.36 1.48e-11 Cerebrospinal fluid biomarker levels; LUSC cis rs7177699 0.557 rs9806363 chr15:79110302 A/G cg15571903 chr15:79123663 NA -0.33 -6.13 -0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg23985595 chr17:80112537 CCDC57 -0.33 -6.48 -0.33 3.24e-10 Life satisfaction; LUSC cis rs11122272 0.735 rs2739510 chr1:231526718 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.7 -0.47 9.19e-20 Hemoglobin concentration; LUSC trans rs11098499 0.863 rs11731756 chr4:120478696 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC trans rs3942852 0.806 rs4752808 chr11:48141252 G/A cg15704280 chr7:45808275 SEPT13 -0.58 -7.11 -0.36 7.12e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs79057730 0.639 rs6463933 chr7:793954 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.66 6.53 0.34 2.5e-10 Initial pursuit acceleration; LUSC cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg21573476 chr21:45109991 RRP1B -0.39 -6.46 -0.33 3.64e-10 Mean corpuscular volume; LUSC trans rs71435601 0.628 rs11897480 chr2:21419320 C/G cg20757404 chr19:378427 NA -0.41 -6.33 -0.33 8.06e-10 Cholesterol, total; LUSC cis rs2832077 0.883 rs11702413 chr21:30188395 A/C cg24692254 chr21:30365293 RNF160 -0.58 -7.22 -0.37 3.57e-12 Cognitive test performance; LUSC cis rs763121 0.819 rs5757126 chr22:38923675 T/C cg14440974 chr22:39074834 NA -0.37 -6.06 -0.31 3.71e-9 Menopause (age at onset); LUSC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg24399712 chr22:39784796 NA -0.61 -10.86 -0.51 1.01e-23 Intelligence (multi-trait analysis); LUSC cis rs11155671 0.530 rs9397398 chr6:150193603 G/A cg07701084 chr6:150067640 NUP43 0.46 6.9 0.35 2.7e-11 Testicular germ cell tumor; LUSC trans rs1941687 0.527 rs1493914 chr18:31362327 C/T cg15819921 chr19:927150 ARID3A -0.42 -6.28 -0.32 1.06e-9 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs3749237 1.000 rs2307021 chr3:49765483 C/G cg21659725 chr3:3221576 CRBN 0.63 8.74 0.43 1.19e-16 Resting heart rate; LUSC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg04346459 chr6:41068666 NFYA;LOC221442 0.46 7.17 0.37 4.76e-12 Alzheimer's disease (late onset); LUSC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19717773 chr7:2847554 GNA12 -0.4 -6.27 -0.32 1.12e-9 Height; LUSC trans rs4729127 1.000 rs61235767 chr7:94016764 T/C cg20086523 chr13:52378287 DHRS12 0.62 6.69 0.34 9.44e-11 Intelligence; LUSC trans rs2898290 0.578 rs34163377 chr8:11450213 C/G cg06636001 chr8:8085503 FLJ10661 0.52 7.65 0.39 2.16e-13 Systolic blood pressure; LUSC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg09035930 chr12:129282057 SLC15A4 -0.66 -13.27 -0.59 1.4e-32 Systemic lupus erythematosus; LUSC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11644478 chr21:40555479 PSMG1 0.96 19.15 0.72 1.11e-55 Cognitive function; LUSC trans rs11098499 0.779 rs28495013 chr4:120375831 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.34 0.33 7.32e-10 Corneal astigmatism; LUSC trans rs35110281 0.774 rs1378080 chr21:45011315 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 9.54 0.46 3.16e-19 Mean corpuscular volume; LUSC cis rs11785693 0.602 rs73190403 chr8:4954798 T/C cg26367366 chr8:4980734 NA 0.7 7.36 0.37 1.4e-12 Neuroticism (multi-trait analysis);Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22000725 chr19:8478147 MARCH2 0.44 6.12 0.32 2.69e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7582180 0.764 rs12622318 chr2:100927375 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.69 -0.43 1.65e-16 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 5.84 0.3 1.24e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs13223928 0.666 rs9986825 chr7:3151177 C/T cg19214707 chr7:3157722 NA 0.52 10.45 0.5 2.73e-22 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.52 -0.34 2.6200000000000003e-10 Alzheimer's disease (late onset); LUSC cis rs7216064 1.000 rs9915108 chr17:65874463 T/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs11098499 0.908 rs11729050 chr4:120300066 T/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs10504073 0.584 rs56078938 chr8:49940342 A/C cg00325661 chr8:49890786 NA 0.71 11.19 0.52 6.91e-25 Blood metabolite ratios; LUSC cis rs1801251 0.896 rs79793315 chr2:233690864 C/T cg25237894 chr2:233734115 C2orf82 -0.35 -6.41 -0.33 4.93e-10 Coronary artery disease; LUSC cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg25427524 chr10:38739819 LOC399744 0.62 11.09 0.52 1.56e-24 Extrinsic epigenetic age acceleration; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg02018176 chr4:1364513 KIAA1530 0.48 8.42 0.42 1.16e-15 Obesity-related traits; LUSC cis rs2348418 1.000 rs2348418 chr12:28689514 T/C cg13890972 chr12:28721907 NA -0.34 -5.87 -0.31 1.05e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg03609598 chr5:56110824 MAP3K1 -0.41 -6.09 -0.32 3.02e-9 Initial pursuit acceleration; LUSC cis rs4917300 0.647 rs4917223 chr8:143115548 C/T cg25363559 chr8:143086065 NA -0.29 -6.61 -0.34 1.56e-10 Amyotrophic lateral sclerosis; LUSC cis rs2153535 1.000 rs11243251 chr6:8368207 G/A cg07606381 chr6:8435919 SLC35B3 -0.5 -7.5 -0.38 5.93e-13 Motion sickness; LUSC cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.39 -0.46 9.83e-19 Schizophrenia; LUSC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg12963246 chr6:28129442 ZNF389 0.54 7.68 0.39 1.78e-13 Depression; LUSC cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.53 -7.48 -0.38 6.55e-13 Multiple sclerosis; LUSC cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12291225 0.679 rs7934671 chr11:14305101 C/T cg19336497 chr11:14380999 RRAS2 -0.56 -11.42 -0.53 1.01e-25 Sense of smell; LUSC cis rs9494145 0.680 rs4895440 chr6:135426558 A/T cg22676075 chr6:135203613 NA 0.58 8.56 0.42 4.3e-16 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.3 0.45 1.9e-18 Prudent dietary pattern; LUSC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg18306943 chr3:40428807 ENTPD3 0.41 6.22 0.32 1.51e-9 Renal cell carcinoma; LUSC cis rs2559856 0.967 rs2559863 chr12:102087108 C/T cg12924262 chr12:102091054 CHPT1 0.43 5.98 0.31 5.66e-9 Blood protein levels; LUSC cis rs922692 0.967 rs11633351 chr15:79056815 C/T cg00540400 chr15:79124168 NA -0.35 -5.93 -0.31 7.67e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg11941060 chr3:133502564 NA 0.49 7.55 0.38 4.08e-13 Iron status biomarkers; LUSC cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg18196295 chr10:418757 DIP2C 0.45 7.37 0.37 1.32e-12 Psychosis in Alzheimer's disease; LUSC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 7.52 0.38 5.18e-13 Breast cancer; LUSC cis rs2456568 0.548 rs7105031 chr11:93661207 C/T cg17595323 chr11:93583763 C11orf90 -0.31 -5.67 -0.3 3.09e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg06544989 chr22:39130855 UNC84B 0.37 6.4 0.33 5.2400000000000005e-10 Menopause (age at onset); LUSC cis rs4629180 0.586 rs57563359 chr2:102125309 A/G cg04415270 chr2:102091202 RFX8 -0.44 -7.64 -0.39 2.36e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg09323728 chr8:95962352 TP53INP1 -0.41 -8.82 -0.43 6.37e-17 Type 2 diabetes; LUSC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg04315214 chr1:2043799 PRKCZ 0.47 9.93 0.48 1.51e-20 Height; LUSC cis rs9818941 1.000 rs9845687 chr3:157682536 T/C cg08654915 chr3:157813417 NA -0.25 -6.25 -0.32 1.23e-9 Height; LUSC cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.02 0.58 1.28e-31 Chronic sinus infection; LUSC cis rs983392 0.836 rs72918674 chr11:59944580 C/T cg24026212 chr11:59952134 MS4A6A -0.36 -6.19 -0.32 1.73e-9 Alzheimer's disease (late onset); LUSC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg15744005 chr10:104629667 AS3MT -0.28 -5.95 -0.31 6.91e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9341835 0.518 rs9361816 chr6:64174439 T/A cg03326410 chr6:64151739 NA -0.37 -6.0 -0.31 5.11e-9 Schizophrenia; LUSC cis rs10752881 1.000 rs12035773 chr1:182985716 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.47 0.65 4.28e-41 Bladder cancer; LUSC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg06494592 chr3:125709126 NA -0.5 -5.68 -0.3 2.89e-8 Blood pressure (smoking interaction); LUSC cis rs6669072 0.669 rs814545 chr1:91240551 C/G cg08895590 chr1:91227319 NA -0.39 -8.68 -0.43 1.81e-16 Cognitive function; LUSC cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg13010199 chr12:38710504 ALG10B -0.59 -9.18 -0.45 4.74e-18 Bladder cancer; LUSC cis rs9303280 0.747 rs1453559 chr17:38020419 T/C cg20243544 chr17:37824526 PNMT 0.4 6.05 0.31 3.9e-9 Self-reported allergy; LUSC cis rs72781680 0.848 rs55725028 chr2:23966447 A/G cg20701182 chr2:24300061 SF3B14 0.75 7.46 0.38 7.57e-13 Lymphocyte counts; LUSC cis rs12995491 0.933 rs34029976 chr2:88537797 T/C cg18302933 chr2:88491318 NA -0.34 -6.53 -0.34 2.39e-10 Response to metformin (IC50); LUSC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg08999081 chr20:33150536 PIGU 0.5 9.95 0.48 1.31e-20 Glomerular filtration rate (creatinine); LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.42 0.42 1.16e-15 Prudent dietary pattern; LUSC cis rs7809950 0.678 rs12670688 chr7:106821016 A/G cg23024343 chr7:107201750 COG5 0.61 8.16 0.41 6.96e-15 Coronary artery disease; LUSC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg07424592 chr7:64974309 NA 0.67 5.88 0.31 9.86e-9 Diabetic kidney disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11196904 chr1:10491304 APITD1 -0.46 -6.17 -0.32 2.02e-9 Bipolar disorder and schizophrenia; LUSC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg10356904 chr22:49881777 NA -0.32 -7.1 -0.36 7.49e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs515186 1 rs515186 chr6:36397492 T/G cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Mean platelet volume; LUSC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg20307385 chr11:47447363 PSMC3 0.43 5.66 0.3 3.33e-8 Subjective well-being; LUSC cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg05253716 chr12:129299332 SLC15A4;MGC16384 0.46 6.74 0.35 6.79e-11 Systemic lupus erythematosus; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg04518342 chr5:131593106 PDLIM4 0.42 8.07 0.4 1.3e-14 Blood metabolite levels; LUSC cis rs8017423 0.935 rs9944124 chr14:90791501 T/C cg14092571 chr14:90743983 NA -0.36 -5.94 -0.31 7.26e-9 Mortality in heart failure; LUSC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg02487422 chr3:49467188 NICN1 0.45 7.18 0.37 4.63e-12 Resting heart rate; LUSC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC cis rs4356932 1.000 rs4371639 chr4:76946569 G/T cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs735860 0.726 rs209519 chr6:53208680 G/A cg10236188 chr6:53219634 NA 0.38 5.7 0.3 2.58e-8 Glaucoma; LUSC cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.44 0.42 9.92e-16 High light scatter reticulocyte count; LUSC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg08048268 chr3:133502702 NA -0.41 -7.41 -0.38 1.07e-12 Iron status biomarkers; LUSC cis rs6960043 0.818 rs10264063 chr7:15053193 G/C cg19272540 chr7:15055459 NA 0.33 8.28 0.41 2.97e-15 Type 2 diabetes; LUSC cis rs6840360 0.571 rs17360371 chr4:152565374 C/T cg22705602 chr4:152727874 NA -0.3 -6.01 -0.31 4.87e-9 Intelligence (multi-trait analysis); LUSC cis rs2315504 1.000 rs2524300 chr17:39040877 C/T cg17985300 chr17:38952333 KRT28 -0.32 -6.67 -0.34 1.05e-10 Height; LUSC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.07 0.4 1.25e-14 Parkinson's disease; LUSC cis rs9640161 0.830 rs1051760 chr7:150070630 A/G cg17279839 chr7:150038598 RARRES2 0.36 5.83 0.3 1.33e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg01475377 chr6:109611718 NA -0.41 -7.35 -0.37 1.54e-12 Reticulocyte fraction of red cells; LUSC cis rs4851254 0.920 rs11686599 chr2:100753475 A/G cg07810366 chr2:100720526 AFF3 -0.38 -5.93 -0.31 7.58e-9 Intelligence (multi-trait analysis); LUSC trans rs643955 0.609 rs13259465 chr8:9982953 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.2 -0.32 1.66e-9 Systemic lupus erythematosus; LUSC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg03929089 chr4:120376271 NA -0.92 -14.53 -0.62 2.07e-37 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04832844 chr4:26321136 RBPJ -0.43 -6.71 -0.34 8.36e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2717559 0.542 rs2585156 chr8:143879795 G/A cg17252645 chr8:143867129 LY6D -0.55 -10.5 -0.5 1.75e-22 Urinary tract infection frequency; LUSC cis rs4851254 0.660 rs114552491 chr2:100709533 C/T cg07810366 chr2:100720526 AFF3 -0.46 -6.16 -0.32 2.05e-9 Intelligence (multi-trait analysis); LUSC cis rs72781680 1.000 rs72796357 chr2:24160131 A/G cg08917208 chr2:24149416 ATAD2B 0.91 10.01 0.48 8.69e-21 Lymphocyte counts; LUSC cis rs62400317 0.614 rs12210292 chr6:44925293 A/G cg20913747 chr6:44695427 NA -0.42 -6.08 -0.32 3.37e-9 Total body bone mineral density; LUSC trans rs7572263 0.724 rs10497896 chr2:209049899 G/C cg21778348 chr7:27194614 HOXA7 -0.47 -6.31 -0.33 9.11e-10 Glioma;Non-glioblastoma glioma; LUSC cis rs2797369 0.546 rs11963911 chr6:101308421 T/C cg12253828 chr6:101329408 ASCC3 0.45 5.74 0.3 2.15e-8 Renal function-related traits (eGRFcrea); LUSC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -8.96 -0.44 2.37e-17 Gut microbiome composition (summer); LUSC cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg13010199 chr12:38710504 ALG10B 0.59 9.2 0.45 3.95e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.37 5.79 0.3 1.62e-8 Platelet count; LUSC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg03188948 chr7:1209495 NA 0.46 6.11 0.32 2.83e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs4332037 0.539 rs4470910 chr7:2071723 C/T cg11693508 chr17:37793320 STARD3 0.51 6.12 0.32 2.69e-9 Bipolar disorder; LUSC trans rs61931739 0.649 rs815028 chr12:33718591 T/C cg26384229 chr12:38710491 ALG10B 0.42 6.13 0.32 2.54e-9 Morning vs. evening chronotype; LUSC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg14019146 chr3:50243930 SLC38A3 0.36 7.98 0.4 2.3e-14 Body mass index; LUSC cis rs55871839 0.708 rs2326213 chr8:59812459 A/G cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs61990749 0.597 rs759808 chr14:78250845 T/G cg02301378 chr14:78227641 SNW1;C14orf178 0.61 6.66 0.34 1.11e-10 Fibroblast growth factor basic levels; LUSC cis rs7180079 0.925 rs56246583 chr15:64534123 A/T cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs58749629 1.000 rs7270354 chr20:44607661 C/T cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.55 -6.24 -0.32 1.33e-9 Abdominal aortic aneurysm; LUSC cis rs6456156 0.586 rs12203510 chr6:167473006 C/T cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.93e-11 Primary biliary cholangitis; LUSC cis rs9815354 1.000 rs1716993 chr3:41974556 G/C cg03022575 chr3:42003672 ULK4 -0.58 -6.4 -0.33 5.41e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs765787 0.530 rs28756676 chr15:45540360 G/A cg25801113 chr15:45476975 SHF 0.34 7.04 0.36 1.13e-11 Uric acid levels; LUSC trans rs5756813 0.688 rs8140207 chr22:38130459 G/T cg19894588 chr14:64061835 NA -0.51 -6.59 -0.34 1.73e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs11696845 0.787 rs6017408 chr20:43363529 A/G cg25301532 chr20:43378953 KCNK15 0.35 6.41 0.33 5.04e-10 Obesity-related traits; LUSC cis rs1451375 1.000 rs10247443 chr7:50620586 G/A cg18232548 chr7:50535776 DDC 0.5 7.49 0.38 6.04e-13 Malaria; LUSC cis rs9929218 0.551 rs4783663 chr16:68720271 T/C cg01251360 chr16:68772225 CDH1 -0.29 -6.7 -0.34 8.93e-11 Colorectal cancer; LUSC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg22800045 chr5:56110881 MAP3K1 0.76 9.57 0.46 2.44e-19 Initial pursuit acceleration; LUSC trans rs62103177 0.525 rs8086024 chr18:77746623 A/G cg05926928 chr17:57297772 GDPD1 -0.8 -9.23 -0.45 3.24e-18 Opioid sensitivity; LUSC trans rs3857536 0.706 rs7755994 chr6:66891747 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg08219700 chr8:58056026 NA 0.66 7.3 0.37 2.11e-12 Developmental language disorder (linguistic errors); LUSC cis rs2282802 0.685 rs7730245 chr5:139628163 C/A cg26211634 chr5:139558579 C5orf32 0.43 8.1 0.41 1.07e-14 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.817 rs1788179 chr8:101333345 A/G cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs6835098 0.924 rs13125240 chr4:174151619 T/C cg08422745 chr4:174089978 GALNT7 0.79 12.29 0.56 6.95e-29 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs11971779 0.648 rs66463279 chr7:139118661 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.16 0.36 5.18e-12 Diisocyanate-induced asthma; LUSC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg24578937 chr1:2090814 PRKCZ -0.43 -9.26 -0.45 2.47e-18 Height; LUSC cis rs1413885 0.516 rs11208637 chr1:65836553 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.49 7.16 0.36 5.09e-12 Anticoagulant levels; LUSC cis rs8014204 0.804 rs7154845 chr14:75247746 A/G cg06637938 chr14:75390232 RPS6KL1 0.65 10.91 0.51 6.45e-24 Caffeine consumption; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs1775715 0.707 rs2799019 chr10:32142850 C/T cg26784012 chr10:32216390 ARHGAP12 0.45 7.62 0.38 2.69e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7215564 0.908 rs74000899 chr17:78653542 T/C cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs4631830 0.869 rs4131357 chr10:51537292 C/A cg10326726 chr10:51549505 MSMB -0.37 -6.38 -0.33 5.77e-10 Prostate-specific antigen levels; LUSC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.09e-11 Blood metabolite levels; LUSC cis rs6005807 0.719 rs9625523 chr22:29045745 T/C cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg17252645 chr8:143867129 LY6D 0.38 6.75 0.35 6.53e-11 Urinary tract infection frequency; LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg23711669 chr6:146136114 FBXO30 0.9 17.11 0.68 1.48e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs1728785 1.000 rs1728789 chr16:68595776 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.22 0.41 4.57e-15 Ulcerative colitis; LUSC cis rs12908161 1.000 rs35630683 chr15:85349231 T/C cg17173187 chr15:85201210 NMB 0.51 9.44 0.46 6.57e-19 Schizophrenia; LUSC cis rs7829975 0.660 rs10093926 chr8:8549020 A/C cg18904891 chr8:8559673 CLDN23 -0.38 -5.66 -0.3 3.19e-8 Mood instability; LUSC cis rs4803468 1.000 rs17318666 chr19:41940342 T/G cg09537434 chr19:41945824 ATP5SL 0.94 16.27 0.66 3.01e-44 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18457491 chr10:104829517 CNNM2 -0.4 -6.1 -0.32 2.87e-9 Hepatitis; LUSC cis rs4363385 0.667 rs2050674 chr1:152913356 C/G cg00922841 chr1:152955080 SPRR1A 0.41 7.14 0.36 5.9e-12 Inflammatory skin disease; LUSC cis rs8062405 0.755 rs12447461 chr16:28582941 C/A cg16576597 chr16:28551801 NUPR1 0.31 6.24 0.32 1.29e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg05425664 chr17:57184151 TRIM37 -0.61 -9.34 -0.46 1.41e-18 Intelligence (multi-trait analysis); LUSC cis rs559928 0.597 rs11600667 chr11:63976183 C/T cg05555928 chr11:63887634 MACROD1 -0.45 -5.66 -0.3 3.23e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs55665837 0.583 rs78843135 chr11:14411254 T/G cg19336497 chr11:14380999 RRAS2 -0.53 -11.22 -0.52 5.31e-25 Vitamin D levels; LUSC cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg06060754 chr5:176797920 RGS14 0.6 9.58 0.46 2.26e-19 Hemoglobin concentration;Hematocrit; LUSC cis rs7264396 0.690 rs2425172 chr20:34443893 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.47 -0.42 7.85e-16 Total cholesterol levels; LUSC cis rs72781680 1.000 rs6751655 chr2:24155478 A/G cg20701182 chr2:24300061 SF3B14 0.74 7.48 0.38 6.68e-13 Lymphocyte counts; LUSC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg22532475 chr10:104410764 TRIM8 -0.35 -7.62 -0.38 2.72e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg27286337 chr10:134555280 INPP5A 0.92 11.97 0.55 1.05e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs11155671 0.530 rs7768665 chr6:150208024 G/A cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.15e-11 Testicular germ cell tumor; LUSC cis rs7107174 0.892 rs4291702 chr11:78001248 C/T cg02023728 chr11:77925099 USP35 0.41 6.02 0.31 4.61e-9 Testicular germ cell tumor; LUSC cis rs921968 0.608 rs832817 chr2:219358603 C/T cg02176678 chr2:219576539 TTLL4 0.64 11.53 0.53 4.11e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg06600287 chr1:53387719 ECHDC2 0.31 6.18 0.32 1.88e-9 Monocyte count; LUSC cis rs9326248 0.581 rs10892048 chr11:116814596 A/G cg26566898 chr11:117069891 TAGLN 0.37 7.0 0.36 1.45e-11 Blood protein levels; LUSC cis rs9905704 0.647 rs11652713 chr17:57079742 C/T cg12560992 chr17:57184187 TRIM37 0.64 10.44 0.5 2.97e-22 Testicular germ cell tumor; LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg16325326 chr1:53192061 ZYG11B 0.89 16.28 0.67 2.74e-44 Monocyte count; LUSC cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg11102782 chr19:18549136 ISYNA1 -0.34 -6.45 -0.33 3.82e-10 Breast cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18555811 chr3:193852889 HES1 -0.42 -6.51 -0.34 2.75e-10 Electrocardiographic conduction measures; LUSC cis rs2346177 0.638 rs34186951 chr2:46657659 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.88 -0.48 2.32e-20 HDL cholesterol; LUSC cis rs12200560 0.505 rs1988040 chr6:97076271 G/A cg06623918 chr6:96969491 KIAA0776 0.5 7.2 0.37 3.9e-12 Coronary heart disease; LUSC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg00933542 chr6:150070202 PCMT1 0.32 6.52 0.34 2.54e-10 Lung cancer; LUSC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.76 -0.3 1.89e-8 Life satisfaction; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg04385144 chr22:27053419 MIAT 0.34 6.01 0.31 4.86e-9 Educational attainment (years of education); LUSC trans rs8002861 0.967 rs7984393 chr13:44484361 T/C cg12856521 chr11:46389249 DGKZ 0.41 6.38 0.33 6.02e-10 Leprosy; LUSC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg21724239 chr8:58056113 NA 0.55 6.37 0.33 6.1e-10 Developmental language disorder (linguistic errors); LUSC trans rs9291683 0.609 rs3796836 chr4:10011345 A/G cg26043149 chr18:55253948 FECH 0.53 7.83 0.39 6.53e-14 Bone mineral density; LUSC cis rs10779751 0.686 rs1148478 chr1:11174067 A/T cg08854313 chr1:11322531 MTOR 0.82 12.73 0.57 1.52e-30 Body mass index; LUSC cis rs7113850 0.541 rs77227176 chr11:24208375 T/C ch.11.24196551F chr11:24239977 NA 0.96 7.47 0.38 7.26e-13 Bone fracture in osteoporosis; LUSC cis rs16854884 0.657 rs62268458 chr3:143736219 T/C cg06585982 chr3:143692056 C3orf58 0.46 7.02 0.36 1.28e-11 Economic and political preferences (feminism/equality); LUSC cis rs2970818 0.831 rs2907498 chr12:4628899 T/C cg11146114 chr12:4671731 NA -0.58 -5.9 -0.31 9.04e-9 Phosphorus levels; LUSC cis rs7216064 0.953 rs11079705 chr17:65835452 A/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.32 -0.45 1.62e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs9931543 0.678 rs876245 chr16:56291212 A/G cg00991179 chr16:56000067 NA -0.34 -5.8 -0.3 1.53e-8 Subjective well-being; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg13395035 chr17:19912177 NA 0.48 6.39 0.33 5.63e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2172802 0.659 rs28713421 chr4:62497085 C/T cg04118610 chr4:62707027 LPHN3 0.45 6.17 0.32 1.94e-9 Partial epilepsies; LUSC cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg01483505 chr11:975446 AP2A2 0.4 5.75 0.3 1.99e-8 Alzheimer's disease (late onset); LUSC cis rs7769051 0.522 rs6928933 chr6:133116073 G/A cg22852734 chr6:133119734 C6orf192 1.34 10.6 0.5 8.1e-23 Type 2 diabetes nephropathy; LUSC cis rs7085104 0.700 rs3740397 chr10:104592675 G/C cg04362960 chr10:104952993 NT5C2 0.6 8.82 0.43 6.56e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6835098 0.961 rs2078475 chr4:174098226 A/C cg08422745 chr4:174089978 GALNT7 0.79 12.53 0.57 8.71e-30 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs2798269 1.000 rs2798269 chr13:22131897 C/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.13 -0.32 2.42e-9 PR segment; LUSC cis rs9875589 0.509 rs6770928 chr3:14077189 G/C cg19554555 chr3:13937349 NA -0.38 -5.68 -0.3 2.87e-8 Ovarian reserve; LUSC cis rs7980687 0.678 rs7132277 chr12:123593382 C/T cg13010344 chr12:123464640 ARL6IP4 0.56 6.67 0.34 1.07e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg08270630 chr22:50330655 NA -0.44 -6.61 -0.34 1.48e-10 Schizophrenia; LUSC cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg23158103 chr7:148848205 ZNF398 -0.49 -8.02 -0.4 1.74e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg26597838 chr10:835615 NA 0.45 5.99 0.31 5.35e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs17445774 1.000 rs1509833 chr2:200865225 G/A cg17644776 chr2:200775616 C2orf69 0.45 6.72 0.35 7.83e-11 LDL cholesterol to HDL cholesterol ratio; LUSC cis rs7582180 0.669 rs4455176 chr2:100876629 T/A cg08017756 chr2:100939284 LONRF2 -0.33 -5.9 -0.31 8.83e-9 Intelligence (multi-trait analysis); LUSC trans rs4714291 0.963 rs1721411 chr6:40102390 T/G cg02267698 chr19:7991119 CTXN1 0.5 6.9 0.35 2.7e-11 Strep throat; LUSC cis rs7208859 0.673 rs9911989 chr17:29237702 A/C cg13385521 chr17:29058706 SUZ12P -0.61 -5.79 -0.3 1.62e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs877282 0.853 rs12779017 chr10:763619 T/C cg22713356 chr15:30763199 NA 1.06 14.16 0.61 5.36e-36 Uric acid levels; LUSC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.96e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.5 -7.09 -0.36 7.89e-12 Mean platelet volume; LUSC cis rs4964805 0.505 rs15918 chr12:104167024 T/C cg02344784 chr12:104178138 NT5DC3 0.37 5.91 0.31 8.25e-9 Attention deficit hyperactivity disorder; LUSC cis rs1371867 0.810 rs2860518 chr8:101238120 G/T cg06002616 chr8:101225028 SPAG1 0.43 7.26 0.37 2.77e-12 Atrioventricular conduction; LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg08736216 chr1:53307985 ZYG11A 0.29 6.03 0.31 4.36e-9 Monocyte count; LUSC trans rs61931739 0.578 rs12582423 chr12:33596502 G/C cg26384229 chr12:38710491 ALG10B -0.41 -6.14 -0.32 2.32e-9 Morning vs. evening chronotype; LUSC cis rs7903847 0.642 rs11189182 chr10:99144186 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.3 -0.37 2.19e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs6681460 1.000 rs4655648 chr1:67114309 C/T cg02459107 chr1:67143332 SGIP1 0.46 8.52 0.42 5.66e-16 Presence of antiphospholipid antibodies; LUSC cis rs36715 1.000 rs40527 chr5:127550252 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.48 6.06 0.31 3.6e-9 Breast cancer; LUSC cis rs892961 0.899 rs3650 chr17:75415835 T/C cg05865280 chr17:75406074 SEPT9 0.49 10.45 0.5 2.7e-22 Airflow obstruction; LUSC cis rs6750047 0.566 rs1157184 chr2:38285774 C/G cg07380506 chr2:38303506 CYP1B1 0.48 6.69 0.34 9.63e-11 Cutaneous malignant melanoma;Melanoma; LUSC trans rs9886428 0.615 rs1365648 chr8:14106151 A/T cg01904776 chr16:2153834 PKD1 -0.36 -6.34 -0.33 7.32e-10 IgG glycosylation; LUSC cis rs308403 0.600 rs309367 chr4:123662211 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.82 11.36 0.53 1.72e-25 Blood protein levels; LUSC cis rs11168618 1.000 rs10875830 chr12:48937510 C/T cg24011408 chr12:48396354 COL2A1 0.39 6.25 0.32 1.26e-9 Adiponectin levels; LUSC cis rs4974559 0.895 rs12646130 chr4:1330530 G/C cg02980000 chr4:1222292 CTBP1 0.76 7.38 0.37 1.24e-12 Systolic blood pressure; LUSC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.46 8.74 0.43 1.19e-16 Hemoglobin concentration; LUSC cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg06671706 chr8:8559999 CLDN23 0.49 6.5 0.34 2.87e-10 Obesity-related traits; LUSC cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg16339924 chr4:17578868 LAP3 0.5 7.32 0.37 1.9e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.15 16.21 0.66 5.28e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1775715 0.737 rs12256714 chr10:32216262 A/G cg18675610 chr10:32216311 ARHGAP12 -0.29 -6.32 -0.33 8.4e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg10377582 chr12:51612794 POU6F1 -0.38 -6.02 -0.31 4.63e-9 Cisplatin-induced ototoxicity; LUSC cis rs11098499 0.754 rs66900435 chr4:120249425 C/A cg09307838 chr4:120376055 NA 0.69 10.53 0.5 1.43e-22 Corneal astigmatism; LUSC cis rs7799006 0.606 rs7792045 chr7:2316852 C/T cg12823233 chr7:2316876 SNX8 -0.43 -7.26 -0.37 2.82e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg12927641 chr6:109611667 NA -0.35 -5.88 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs4805272 0.582 rs11083652 chr19:29231569 G/C cg04546413 chr19:29218101 NA -0.47 -7.99 -0.4 2.18e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs738322 0.967 rs133024 chr22:38574066 C/T cg25457927 chr22:38595422 NA 0.38 7.82 0.39 6.97e-14 Cutaneous nevi; LUSC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg25272121 chr1:152190972 HRNR -0.39 -6.78 -0.35 5.44e-11 Inflammatory skin disease; LUSC cis rs7575217 0.588 rs2278729 chr2:101668857 C/T cg23907051 chr2:101730305 TBC1D8 0.26 6.43 0.33 4.53e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs4499344 0.633 rs259271 chr19:33157100 A/G cg22980127 chr19:33182716 NUDT19 -0.44 -6.45 -0.33 3.88e-10 Mean platelet volume; LUSC cis rs3768617 0.510 rs7542640 chr1:183063738 G/A ch.1.3577855R chr1:183094577 LAMC1 0.7 10.75 0.51 2.35e-23 Fuchs's corneal dystrophy; LUSC cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.37 -0.42 1.57e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg04287289 chr16:89883240 FANCA 0.74 5.86 0.31 1.1e-8 Skin colour saturation; LUSC cis rs2404602 0.647 rs12898810 chr15:76904738 T/C cg23625390 chr15:77176239 SCAPER -0.65 -9.55 -0.46 2.88e-19 Blood metabolite levels; LUSC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.57 0.38 3.58e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs4132509 0.793 rs9428579 chr1:243690034 C/T cg21452805 chr1:244014465 NA 0.58 6.24 0.32 1.3e-9 RR interval (heart rate); LUSC cis rs3540 0.533 rs4932342 chr15:90982923 C/T cg22089800 chr15:90895588 ZNF774 0.61 9.31 0.45 1.74e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg08888203 chr3:10149979 C3orf24 0.6 8.28 0.41 3e-15 Alzheimer's disease; LUSC cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg16615211 chr3:44902933 MIR564;TMEM42 0.39 6.78 0.35 5.61e-11 Depressive symptoms; LUSC cis rs79976124 0.760 rs74295030 chr6:66654441 T/C cg07460842 chr6:66804631 NA 0.73 9.13 0.45 6.67e-18 Type 2 diabetes; LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg07395648 chr5:131743802 NA -0.4 -6.05 -0.31 3.84e-9 Breast cancer; LUSC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg06028605 chr16:24865363 SLC5A11 0.7 10.72 0.51 2.99e-23 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.5 0.46 4.05e-19 Bipolar disorder; LUSC cis rs9303401 0.659 rs17222621 chr17:56695923 C/T cg25039879 chr17:56429692 SUPT4H1 0.66 8.97 0.44 2.22e-17 Cognitive test performance; LUSC trans rs57221529 0.655 rs11948381 chr5:568413 A/T cg25482853 chr8:67687455 SGK3 1.03 16.33 0.67 1.71e-44 Lung disease severity in cystic fibrosis; LUSC cis rs7241530 0.662 rs12454671 chr18:75908918 G/C cg14642773 chr18:75888474 NA 0.39 5.65 0.3 3.43e-8 Educational attainment (years of education); LUSC cis rs2109514 1.000 rs2270188 chr7:116140524 G/T cg12739419 chr7:116140593 CAV2 -0.29 -6.3 -0.33 9.14e-10 Prevalent atrial fibrillation; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17365369 chr19:52773256 ZNF766 -0.46 -6.08 -0.32 3.38e-9 Bipolar disorder and schizophrenia; LUSC cis rs34684276 1 rs34684276 chr15:78813155 G/A cg06917634 chr15:78832804 PSMA4 -0.48 -6.61 -0.34 1.56e-10 Nicotine dependence;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.09 0.36 7.97e-12 Colorectal cancer; LUSC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg04944784 chr2:26401820 FAM59B -0.69 -10.13 -0.48 3.31e-21 Gut microbiome composition (summer); LUSC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg18252515 chr7:66147081 NA -1.21 -13.94 -0.61 4.07e-35 Diabetic kidney disease; LUSC cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg24562669 chr7:97807699 LMTK2 -0.41 -7.19 -0.37 4.15e-12 Breast cancer; LUSC trans rs35275482 0.573 rs7163623 chr15:60060482 C/T cg17779764 chr5:159685142 CCNJL 0.44 6.59 0.34 1.7e-10 Gut microbiota (bacterial taxa); LUSC cis rs9467773 0.838 rs3734540 chr6:26463321 A/C cg12292205 chr6:26970375 C6orf41 0.38 6.1 0.32 2.97e-9 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.955 rs11931312 chr4:120159023 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.27 0.32 1.09e-9 Corneal astigmatism; LUSC cis rs77106637 1.000 rs76793820 chr11:72619860 G/A cg03878208 chr11:72483293 STARD10 0.58 7.45 0.38 8.3e-13 Type 2 diabetes; LUSC trans rs7937682 0.883 rs553632 chr11:111462897 C/T cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.62 0.34 1.45e-10 Lung cancer; LUSC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.9 -0.55 1.77e-27 Extrinsic epigenetic age acceleration; LUSC cis rs7568458 0.684 rs7593969 chr2:85809670 A/G cg23752985 chr2:85803571 VAMP8 -0.33 -6.37 -0.33 6.09e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2273669 0.667 rs12195836 chr6:109357701 T/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg24675658 chr1:53192096 ZYG11B 0.57 8.88 0.44 4.22e-17 Monocyte count; LUSC cis rs4819052 0.679 rs2236450 chr21:46702553 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 11.54 0.53 3.75e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg21132104 chr15:45694354 SPATA5L1 0.56 7.82 0.39 7.06e-14 Homoarginine levels; LUSC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.96 0.4 2.78e-14 Parkinson's disease; LUSC trans rs1493916 0.870 rs7239173 chr18:31395534 A/T cg13755796 chr4:20253514 NA -0.42 -6.61 -0.34 1.55e-10 Life satisfaction; LUSC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg06640241 chr16:89574553 SPG7 0.87 15.62 0.65 1.08e-41 Multiple myeloma (IgH translocation); LUSC cis rs2286885 1.000 rs10819171 chr9:129253074 G/A cg15282417 chr9:129245246 FAM125B 0.42 7.06 0.36 9.62e-12 Intraocular pressure; LUSC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg02574844 chr11:5959923 NA -0.48 -7.21 -0.37 3.74e-12 DNA methylation (variation); LUSC cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg23788917 chr6:8435910 SLC35B3 0.51 7.48 0.38 6.83e-13 Motion sickness; LUSC cis rs698813 0.674 rs3738985 chr2:44502788 A/C cg00619915 chr2:44497795 NA -0.49 -6.76 -0.35 6.06e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs2573652 0.722 rs12908133 chr15:100544405 G/A cg00587665 chr15:100533223 ADAMTS17 -0.37 -6.64 -0.34 1.24e-10 Height; LUSC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18404041 chr3:52824283 ITIH1 -0.52 -9.86 -0.47 2.69e-20 Electroencephalogram traits; LUSC cis rs4343996 0.902 rs4336505 chr7:3373740 A/C cg21248987 chr7:3385318 SDK1 -0.38 -6.42 -0.33 4.75e-10 Motion sickness; LUSC cis rs2742417 0.624 rs2673030 chr3:45757900 T/G cg04837898 chr3:45731254 SACM1L -0.43 -6.96 -0.36 1.79e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7215564 0.908 rs901066 chr17:78659617 C/G cg09596252 chr17:78655493 RPTOR 0.52 6.18 0.32 1.9e-9 Myopia (pathological); LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.43 0.53 9.43e-26 Alzheimer's disease; LUSC trans rs2262909 0.962 rs55735642 chr19:22241176 C/T cg05197062 chr11:11642011 GALNTL4 0.56 7.88 0.4 4.75e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.78 -0.39 9.28e-14 Personality dimensions; LUSC cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg01483505 chr11:975446 AP2A2 0.41 5.87 0.31 1.03e-8 Alzheimer's disease (late onset); LUSC cis rs1577917 0.958 rs12212480 chr6:86458777 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -9.05 -0.44 1.23e-17 Response to antipsychotic treatment; LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg02951883 chr7:2050386 MAD1L1 -0.38 -6.51 -0.34 2.68e-10 Bipolar disorder and schizophrenia; LUSC cis rs6445967 1.000 rs6777105 chr3:58307644 A/G cg13750441 chr3:58318267 PXK -0.29 -5.84 -0.3 1.27e-8 Platelet count; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg04296578 chr1:45671659 ZSWIM5 0.35 6.24 0.32 1.36e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs17270561 0.609 rs1165155 chr6:25795577 A/T cg17691542 chr6:26056736 HIST1H1C 0.46 6.56 0.34 2.02e-10 Iron status biomarkers; LUSC cis rs9807841 0.670 rs8113002 chr19:10776606 A/T cg09936142 chr19:10668400 KRI1 -0.41 -6.51 -0.34 2.74e-10 Inflammatory skin disease; LUSC cis rs11190604 1.000 rs4919469 chr10:102298855 C/A cg16342193 chr10:102329863 NA -0.36 -6.56 -0.34 2.08e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg13560548 chr3:10150139 C3orf24 0.53 7.43 0.38 9.1e-13 Alzheimer's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03771185 chr4:775700 NA 0.48 7.24 0.37 3.04e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg20476274 chr7:133979776 SLC35B4 0.88 16.76 0.68 3.47e-46 Mean platelet volume; LUSC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.28 -0.53 3.08e-25 Schizophrenia; LUSC cis rs9925964 0.933 rs11150604 chr16:31037020 A/T cg02466173 chr16:30829666 NA 0.38 6.87 0.35 3.1e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Bladder cancer; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.8 -0.57 8.83e-31 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20421914 chr13:100153689 TM9SF2 0.44 5.99 0.31 5.49e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.82 11.44 0.53 8.89e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9430161 0.579 rs7542164 chr1:11040223 G/A cg02454025 chr1:11042201 C1orf127 0.91 16.95 0.68 6.13e-47 Ewing sarcoma; LUSC cis rs3771570 0.901 rs73006381 chr2:242406654 G/C cg21155796 chr2:242212141 HDLBP 0.61 6.96 0.36 1.8e-11 Prostate cancer; LUSC cis rs7191439 0.858 rs2340973 chr16:88773396 G/A cg27087555 chr16:88793112 FAM38A -1.45 -12.59 -0.57 5.26e-30 Plateletcrit; LUSC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg01416388 chr22:39784598 NA -0.4 -6.06 -0.31 3.57e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg05872129 chr22:39784769 NA 0.58 10.96 0.51 4.5e-24 Intelligence (multi-trait analysis); LUSC trans rs877282 0.945 rs11253388 chr10:787852 A/G cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs6539267 0.741 rs7314289 chr12:106686260 A/C cg02476566 chr12:106696527 TCP11L2 0.52 6.58 0.34 1.83e-10 Tourette syndrome; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg13047869 chr3:10149882 C3orf24 0.59 7.65 0.39 2.1e-13 Alzheimer's disease; LUSC cis rs1801251 1.000 rs12987513 chr2:233622066 A/G cg08000102 chr2:233561755 GIGYF2 0.7 11.72 0.54 8e-27 Coronary artery disease; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg16778527 chr15:45406477 DUOX2;DUOXA2 0.38 6.16 0.32 2.14e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg02772935 chr3:125709198 NA -0.48 -6.16 -0.32 2.03e-9 Blood pressure (smoking interaction); LUSC cis rs4285028 0.747 rs1128163 chr3:121350573 A/G cg11130432 chr3:121712080 ILDR1 -0.57 -8.25 -0.41 3.67e-15 Multiple sclerosis; LUSC cis rs12200782 0.505 rs9295696 chr6:26550288 C/T cg11502198 chr6:26597334 ABT1 0.92 11.43 0.53 9.62e-26 Small cell lung carcinoma; LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02475777 chr4:1388615 CRIPAK 0.63 9.44 0.46 6.66e-19 Longevity; LUSC cis rs7909074 0.509 rs2026427 chr10:45389704 T/C cg05187965 chr10:45406764 TMEM72 -0.29 -5.81 -0.3 1.49e-8 Mean corpuscular volume; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg07092213 chr7:1199455 ZFAND2A -0.6 -9.66 -0.47 1.28e-19 Longevity;Endometriosis; LUSC cis rs12545109 1.000 rs12545109 chr8:57313906 A/C cg09654669 chr8:57350985 NA -0.59 -8.32 -0.41 2.27e-15 Obesity-related traits; LUSC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg13628971 chr7:2884303 GNA12 0.48 6.72 0.35 7.76e-11 Height; LUSC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg04944784 chr2:26401820 FAM59B -0.69 -9.74 -0.47 6.8e-20 Gut microbiome composition (summer); LUSC cis rs7572644 0.679 rs6745545 chr2:28021845 C/G cg27432699 chr2:27873401 GPN1 0.57 7.39 0.37 1.2e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs6061231 0.505 rs13037253 chr20:60928724 G/A cg22601191 chr20:60968625 CABLES2 0.45 6.28 0.32 1.07e-9 Colorectal cancer; LUSC cis rs7851660 0.844 rs13287360 chr9:100637681 A/G cg13688889 chr9:100608707 NA -0.55 -8.34 -0.42 1.91e-15 Strep throat; LUSC cis rs17661538 0.504 rs34074414 chr10:18467874 T/C cg03634479 chr10:18430412 CACNB2 0.63 5.92 0.31 8.04e-9 Response to antipsychotic treatment; LUSC cis rs1878931 0.567 rs7196196 chr16:3411855 C/A cg22508957 chr16:3507546 NAT15 -0.37 -6.0 -0.31 5.08e-9 Body mass index (adult); LUSC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg01475377 chr6:109611718 NA -0.41 -7.31 -0.37 1.97e-12 Reticulocyte fraction of red cells; LUSC trans rs7448080 0.510 rs10519745 chr5:123347613 C/T cg10068417 chr13:50706583 NA 0.43 6.33 0.33 7.68e-10 Alcohol dependence (age at onset); LUSC trans rs9388451 0.807 rs1268065 chr6:126042783 G/A cg05039488 chr6:79577232 IRAK1BP1 0.56 8.89 0.44 3.96e-17 Brugada syndrome; LUSC cis rs1568889 1.000 rs12808162 chr11:28067027 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 9.28 0.45 2.27e-18 Bipolar disorder; LUSC cis rs7582180 0.764 rs10180423 chr2:100919012 C/G cg08017756 chr2:100939284 LONRF2 -0.42 -7.82 -0.39 6.79e-14 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19197750 chr7:43966251 URGCP;UBE2D4 -0.41 -5.97 -0.31 6.06e-9 Electrocardiographic conduction measures; LUSC cis rs9653442 0.564 rs2309756 chr2:100780269 G/C cg22139774 chr2:100720529 AFF3 -0.41 -7.12 -0.36 6.51e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7582180 0.627 rs4851312 chr2:101011241 G/A cg12002119 chr2:101014098 CHST10 0.37 6.19 0.32 1.78e-9 Intelligence (multi-trait analysis); LUSC cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg08645402 chr16:4508243 NA -0.46 -7.22 -0.37 3.49e-12 Schizophrenia; LUSC cis rs10892173 0.566 rs10892174 chr11:117672565 A/C cg21640587 chr11:117668038 DSCAML1 0.67 9.85 0.47 2.8e-20 Myopia; LUSC trans rs8040855 0.965 rs1961276 chr15:85714217 C/T cg00988175 chr11:59481031 OR10V1 0.29 6.38 0.33 5.82e-10 Bulimia nervosa; LUSC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.33 0.37 1.8e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg21970626 chr13:21893289 NA -0.43 -5.77 -0.3 1.85e-8 White matter hyperintensity burden; LUSC cis rs2235649 0.833 rs9929185 chr16:1852070 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -5.94 -0.31 7.18e-9 Blood metabolite levels; LUSC cis rs3768617 1.000 rs3820697 chr1:183100226 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.87 0.44 4.47e-17 Fuchs's corneal dystrophy; LUSC cis rs10904908 0.795 rs359283 chr10:17326254 A/G cg01003015 chr10:17271136 VIM 0.39 5.65 0.3 3.37e-8 Total cholesterol levels;Cholesterol, total; LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg22166914 chr1:53195759 ZYG11B 0.55 8.95 0.44 2.45e-17 Monocyte count; LUSC cis rs6977660 0.714 rs4719585 chr7:19823727 C/G cg05791153 chr7:19748676 TWISTNB 0.67 6.93 0.35 2.24e-11 Thyroid stimulating hormone; LUSC trans rs61931739 0.500 rs34287388 chr12:34444626 C/A cg13010199 chr12:38710504 ALG10B 0.68 10.81 0.51 1.43e-23 Morning vs. evening chronotype; LUSC cis rs909341 0.909 rs2872881 chr20:62342801 G/A cg09650180 chr20:62225654 GMEB2 -0.44 -5.67 -0.3 3.13e-8 Atopic dermatitis; LUSC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg00152838 chr16:24741724 TNRC6A 0.45 5.68 0.3 3.01e-8 Intelligence (multi-trait analysis); LUSC trans rs3736485 0.966 rs10775144 chr15:51891134 C/T cg09125779 chr4:57547999 HOPX 0.33 5.97 0.31 5.97e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.37 -5.96 -0.31 6.49e-9 IgG glycosylation; LUSC cis rs9790314 1.000 rs163328 chr3:161073599 A/G cg03342759 chr3:160939853 NMD3 -0.48 -8.18 -0.41 5.83e-15 Morning vs. evening chronotype; LUSC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg26597838 chr10:835615 NA 1.24 15.78 0.65 2.58e-42 Eosinophil percentage of granulocytes; LUSC cis rs12458462 0.892 rs2242175 chr18:77464406 G/A cg11879182 chr18:77439856 CTDP1 0.73 12.08 0.55 4.1e-28 Monocyte count; LUSC cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg22601191 chr20:60968625 CABLES2 0.41 5.95 0.31 6.76e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg22638593 chr5:131593259 PDLIM4 -0.41 -5.88 -0.31 9.89e-9 Breast cancer; LUSC cis rs9326248 0.652 rs7128382 chr11:117023487 A/C cg16524733 chr11:117070046 TAGLN 0.37 5.88 0.31 1.01e-8 Blood protein levels; LUSC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg19592336 chr6:28129416 ZNF389 0.48 6.25 0.32 1.22e-9 Depression; LUSC cis rs1670533 1.000 rs6852155 chr4:1067638 T/G cg02018176 chr4:1364513 KIAA1530 0.44 6.27 0.32 1.14e-9 Recombination rate (females); LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC trans rs61931739 0.500 rs7309931 chr12:34483471 A/C cg26384229 chr12:38710491 ALG10B 0.79 13.51 0.59 1.72e-33 Morning vs. evening chronotype; LUSC cis rs7572644 0.640 rs6744348 chr2:28018025 A/C cg27432699 chr2:27873401 GPN1 0.56 7.27 0.37 2.54e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg08847533 chr14:75593920 NEK9 -0.81 -13.83 -0.6 1.08e-34 Height; LUSC cis rs34366173 1 rs34366173 chr15:63998914 CTT/C cg14776518 chr15:63892607 FBXL22 0.38 6.09 0.32 3.03e-9 Reticulocyte fraction of red cells; LUSC cis rs4077515 0.577 rs10870165 chr9:139316601 C/T cg14169450 chr9:139327907 INPP5E 0.41 7.23 0.37 3.38e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12667521 chr19:29218732 NA 0.62 8.6 0.43 3.11e-16 Methadone dose in opioid dependence; LUSC cis rs6582630 0.598 rs10880645 chr12:38556172 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.52 -0.34 2.61e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs6952808 1.000 rs10233560 chr7:1885415 T/C cg24247370 chr13:99142703 STK24 -0.34 -6.27 -0.32 1.08e-9 Bipolar disorder and schizophrenia; LUSC trans rs12524093 0.541 rs75512107 chr6:143041952 T/G cg22454011 chr18:13611439 C18orf1 0.68 5.96 0.31 6.53e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg07636037 chr3:49044803 WDR6 0.71 10.66 0.5 4.98e-23 Menarche (age at onset); LUSC cis rs546131 0.928 rs547504 chr11:34847225 G/T cg11058730 chr11:34937778 PDHX;APIP 0.45 6.14 0.32 2.35e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.21 -0.37 3.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6541297 0.645 rs4846919 chr1:230301451 A/G cg05784532 chr1:230284198 GALNT2 0.57 6.73 0.35 7.4e-11 Coronary artery disease; LUSC trans rs11722228 0.549 rs73212828 chr4:10078756 C/T cg26043149 chr18:55253948 FECH 0.98 14.53 0.62 2.08e-37 Gout;Urate levels;Serum uric acid levels; LUSC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.38 8.03 0.4 1.68e-14 Hemoglobin concentration; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg16145915 chr7:1198662 ZFAND2A -0.52 -10.0 -0.48 8.83e-21 Longevity;Endometriosis; LUSC cis rs11676855 0.893 rs6721399 chr2:235936607 A/G cg14917874 chr2:235941519 SH3BP4 0.51 8.7 0.43 1.56e-16 Dialysis-related mortality; LUSC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.47 -0.33 3.41e-10 High light scatter reticulocyte count; LUSC cis rs983392 0.836 rs7946992 chr11:59944810 T/C cg24026212 chr11:59952134 MS4A6A -0.37 -6.23 -0.32 1.41e-9 Alzheimer's disease (late onset); LUSC cis rs7568458 0.837 rs35565292 chr2:85790316 T/A cg23752985 chr2:85803571 VAMP8 0.36 7.52 0.38 5.03e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg02463440 chr8:22132932 PIWIL2 0.44 8.0 0.4 2.1e-14 Hypertriglyceridemia; LUSC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg12365402 chr11:9010492 NRIP3 -0.47 -8.98 -0.44 2.03e-17 Hemoglobin concentration; LUSC cis rs34375054 0.641 rs34624329 chr12:125608028 T/G cg25124228 chr12:125621409 AACS -0.48 -7.67 -0.39 1.9e-13 Post bronchodilator FEV1/FVC ratio; LUSC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg16325326 chr1:53192061 ZYG11B 0.93 17.71 0.7 6.01e-50 Monocyte count; LUSC cis rs2273669 0.667 rs76732622 chr6:109318280 A/T cg05315195 chr6:109294784 ARMC2 -0.55 -5.87 -0.31 1.03e-8 Prostate cancer; LUSC cis rs7197653 0.748 rs2279538 chr16:68397106 C/G cg05110241 chr16:68378359 PRMT7 -0.78 -8.89 -0.44 3.82e-17 Magnesium levels; LUSC cis rs950169 0.922 rs17531523 chr15:85132449 C/G cg17507749 chr15:85114479 UBE2QP1 0.69 8.73 0.43 1.23e-16 Schizophrenia; LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.823 rs11689269 chr2:15621917 C/G cg19274914 chr2:15703543 NA 0.46 8.82 0.43 6.51e-17 Educational attainment (years of education); LUSC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg09044154 chr16:88155775 NA -0.55 -7.49 -0.38 6.21e-13 Menopause (age at onset); LUSC cis rs9359856 0.879 rs4707552 chr6:90300841 A/G cg13799429 chr6:90582589 CASP8AP2 0.57 6.67 0.34 1.04e-10 Bipolar disorder; LUSC trans rs6600671 0.967 rs11249349 chr1:121179169 G/C cg00646200 chr1:148855367 NA 0.47 7.52 0.38 5.11e-13 Hip geometry; LUSC cis rs9640161 0.658 rs74348353 chr7:150053655 C/A cg21361702 chr7:150065534 REPIN1 0.57 8.02 0.4 1.77e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs6582630 0.537 rs66855609 chr12:38299029 T/C cg06521331 chr12:34319734 NA -0.42 -6.51 -0.34 2.71e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs1372520 0.684 rs3113355 chr4:90745345 A/T cg01966878 chr4:90757139 SNCA -0.4 -5.69 -0.3 2.78e-8 Neuroticism; LUSC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg07716408 chr11:68623521 NA -0.33 -6.38 -0.33 6.04e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg19901468 chr14:105411992 AHNAK2 -0.71 -12.34 -0.56 4.38e-29 Rheumatoid arthritis; LUSC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg13319975 chr6:146136371 FBXO30 -0.67 -10.51 -0.5 1.69e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.87 -0.4 4.85e-14 Blood metabolite levels; LUSC trans rs61931739 0.500 rs11053185 chr12:34428857 A/G cg13010199 chr12:38710504 ALG10B 0.58 9.18 0.45 4.57e-18 Morning vs. evening chronotype; LUSC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg01475377 chr6:109611718 NA -0.38 -6.69 -0.34 9.16e-11 Reticulocyte fraction of red cells; LUSC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg16228356 chr17:43848958 NA 0.28 6.46 0.33 3.75e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg24250549 chr1:154909240 PMVK 0.65 10.87 0.51 9.05e-24 Prostate cancer; LUSC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC cis rs9815354 0.812 rs73069209 chr3:41939781 G/A cg03022575 chr3:42003672 ULK4 0.82 8.59 0.43 3.4e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg00431813 chr7:1051703 C7orf50 -0.43 -6.96 -0.36 1.83e-11 Longevity;Endometriosis; LUSC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg06740227 chr12:86229804 RASSF9 0.37 5.91 0.31 8.3e-9 Major depressive disorder; LUSC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.76 0.35 6.02e-11 Lung cancer; LUSC cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -5.97 -0.31 5.96e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg14784868 chr12:69753453 YEATS4 0.89 15.67 0.65 7.27e-42 Cerebrospinal fluid biomarker levels; LUSC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg13877915 chr19:58951672 ZNF132 0.49 7.75 0.39 1.12e-13 Uric acid clearance; LUSC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg22601191 chr20:60968625 CABLES2 0.42 5.91 0.31 8.6e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg04315214 chr1:2043799 PRKCZ 0.48 10.2 0.49 1.92e-21 Height; LUSC cis rs4268898 1.000 rs2303294 chr2:24432620 A/G cg06627628 chr2:24431161 ITSN2 0.63 9.31 0.45 1.78e-18 Asthma; LUSC cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 8.16e-15 Axial length; LUSC cis rs4474465 1.000 rs10751290 chr11:78192707 G/A cg27205649 chr11:78285834 NARS2 -0.53 -6.13 -0.32 2.43e-9 Alzheimer's disease (survival time); LUSC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.05e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7208859 0.524 rs8065744 chr17:29099449 C/T cg13385521 chr17:29058706 SUZ12P 0.69 6.79 0.35 5.27e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg10729496 chr3:10149963 C3orf24 0.56 6.97 0.36 1.7e-11 Alzheimer's disease; LUSC trans rs330071 0.686 rs4841139 chr8:9249210 C/T cg06636001 chr8:8085503 FLJ10661 0.49 7.4 0.38 1.12e-12 Acne (severe); LUSC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg19592336 chr6:28129416 ZNF389 0.49 6.56 0.34 2e-10 Depression; LUSC cis rs6058796 1.000 rs6087972 chr20:31268102 A/G cg13636640 chr20:31349939 DNMT3B 0.54 5.75 0.3 1.99e-8 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg23791538 chr6:167370224 RNASET2 0.42 6.82 0.35 4.24e-11 Crohn's disease; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg07217954 chr7:1067459 C7orf50 0.53 5.68 0.3 2.91e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg21238619 chr17:78079768 GAA -0.3 -5.97 -0.31 6.2e-9 Yeast infection; LUSC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg15448220 chr1:150897856 SETDB1 -0.41 -6.15 -0.32 2.27e-9 Melanoma; LUSC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.94 -0.4 3.13e-14 Mean platelet volume; LUSC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.27 0.59 1.47e-32 Total body bone mineral density; LUSC cis rs11608355 1.000 rs11066523 chr12:109851899 A/G cg05360138 chr12:110035743 NA -0.46 -6.31 -0.33 8.91e-10 Neuroticism; LUSC cis rs7580658 0.891 rs3768866 chr2:128045415 G/A cg09760422 chr2:128146352 NA -0.33 -7.18 -0.37 4.46e-12 Protein C levels; LUSC cis rs8114671 0.869 rs1407202 chr20:33651967 C/T cg07148914 chr20:33460835 GGT7 -0.46 -6.86 -0.35 3.38e-11 Height; LUSC cis rs11051970 0.545 rs2651375 chr12:32582652 G/T cg02745156 chr12:32552066 NA -0.36 -6.51 -0.34 2.73e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.45 0.56 1.79e-29 Chronic sinus infection; LUSC cis rs8114671 0.967 rs2065978 chr20:33767291 C/T cg07148914 chr20:33460835 GGT7 0.47 6.93 0.35 2.24e-11 Height; LUSC cis rs4845459 0.935 rs4845449 chr1:152591024 A/T cg08895932 chr1:152778580 LCE1C -0.36 -6.22 -0.32 1.47e-9 Psoriasis; LUSC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg27165867 chr14:105738592 BRF1 0.52 7.7 0.39 1.59e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs7267979 0.966 rs6037083 chr20:25290543 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.69e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9875589 0.509 rs1601868 chr3:14065450 T/C cg19554555 chr3:13937349 NA -0.38 -5.71 -0.3 2.47e-8 Ovarian reserve; LUSC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.6 8.11 0.41 9.68e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7189233 0.531 rs1072910 chr16:53499599 A/G cg09728985 chr16:53543985 NA -0.31 -5.87 -0.31 1.08e-8 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg02782426 chr3:40428986 ENTPD3 0.4 7.57 0.38 3.69e-13 Renal cell carcinoma; LUSC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg13647721 chr17:30228624 UTP6 -0.62 -5.89 -0.31 9.27e-9 Hip circumference adjusted for BMI; LUSC cis rs950776 0.593 rs481134 chr15:78877563 C/T cg06917634 chr15:78832804 PSMA4 0.75 13.1 0.58 6.12e-32 Sudden cardiac arrest; LUSC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg09365446 chr1:150670422 GOLPH3L 0.48 6.99 0.36 1.47e-11 Melanoma; LUSC cis rs10464366 0.560 rs12672089 chr7:39132816 G/A cg15212455 chr7:39170539 POU6F2 0.57 9.32 0.45 1.68e-18 IgG glycosylation; LUSC cis rs9916302 0.706 rs1877030 chr17:37740161 T/C cg07936489 chr17:37558343 FBXL20 -0.83 -9.48 -0.46 4.76e-19 Glomerular filtration rate (creatinine); LUSC cis rs9457247 0.602 rs2157388 chr6:167481912 G/A cg25258033 chr6:167368657 RNASET2 0.45 6.79 0.35 5.29e-11 Crohn's disease; LUSC cis rs8028313 0.630 rs4776373 chr15:67960523 G/A cg05925327 chr15:68127851 NA -0.43 -6.77 -0.35 5.91e-11 Obesity; LUSC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg17376030 chr22:41985996 PMM1 -0.47 -6.01 -0.31 4.91e-9 Vitiligo; LUSC cis rs6982240 0.514 rs892362 chr8:142269214 A/G cg00131261 chr8:142287264 NA 0.38 6.36 0.33 6.68e-10 Tonsillectomy; LUSC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.89 0.51 8.06e-24 Monocyte percentage of white cells; LUSC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg09699651 chr6:150184138 LRP11 0.46 7.29 0.37 2.25e-12 Testicular germ cell tumor; LUSC cis rs7937682 0.924 rs513425 chr11:111504861 C/T cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs9790314 0.967 rs336586 chr3:161081347 G/A cg04691961 chr3:161091175 C3orf57 -0.35 -6.08 -0.32 3.22e-9 Morning vs. evening chronotype; LUSC cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.68 -0.43 1.71e-16 Body mass index; LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.71 0.43 1.47e-16 Alzheimer's disease; LUSC cis rs62400317 0.859 rs12191751 chr6:45282111 G/T cg18551225 chr6:44695536 NA -0.42 -7.06 -0.36 9.47e-12 Total body bone mineral density; LUSC cis rs210142 1.000 rs210142 chr6:33546837 T/C cg07679836 chr6:33548423 BAK1 0.51 8.07 0.4 1.3e-14 Platelet count;Plateletcrit;Chronic lymphocytic leukemia; LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg21724239 chr8:58056113 NA 0.8 8.59 0.43 3.29e-16 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.01e-11 Tonsillectomy; LUSC cis rs7927592 0.913 rs3824850 chr11:68341873 A/G cg01657329 chr11:68192670 LRP5 -0.4 -5.73 -0.3 2.24e-8 Total body bone mineral density; LUSC cis rs11864453 0.647 rs7194397 chr16:72128299 C/T cg16558253 chr16:72132732 DHX38 -0.38 -5.92 -0.31 7.95e-9 Fibrinogen levels; LUSC cis rs10489202 0.954 rs12403023 chr1:168086999 A/G cg24449463 chr1:168025552 DCAF6 -0.56 -7.14 -0.36 6.01e-12 Schizophrenia; LUSC cis rs7973719 0.833 rs11044332 chr12:7358768 C/A cg07052231 chr12:7363540 PEX5 0.54 9.42 0.46 7.85e-19 IgG glycosylation; LUSC cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -8.35 -0.42 1.79e-15 Bone mineral density; LUSC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg07741184 chr6:167504864 NA 0.43 7.56 0.38 3.86e-13 Crohn's disease; LUSC cis rs35079168 0.923 rs12115573 chr9:137288782 G/A cg13941235 chr9:137270186 RXRA -0.32 -5.68 -0.3 2.91e-8 Intelligence; LUSC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg22823121 chr1:150693482 HORMAD1 0.49 7.18 0.37 4.69e-12 Melanoma; LUSC cis rs17095355 1.000 rs12265204 chr10:111752163 T/C cg00817464 chr10:111662876 XPNPEP1 -0.65 -8.04 -0.4 1.55e-14 Biliary atresia; LUSC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg08975724 chr8:8085496 FLJ10661 -0.54 -8.0 -0.4 2e-14 Systolic blood pressure; LUSC cis rs11971779 0.616 rs6467836 chr7:139023517 C/G cg23387468 chr7:139079360 LUC7L2 0.42 6.36 0.33 6.67e-10 Diisocyanate-induced asthma; LUSC cis rs7582720 1.000 rs76298043 chr2:203814694 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs113835537 0.627 rs4630309 chr11:66333072 A/C cg24851651 chr11:66362959 CCS -0.53 -6.61 -0.34 1.49e-10 Airway imaging phenotypes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16909824 chr1:151299438 PI4KB 0.44 5.97 0.31 6.04e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7103648 0.669 rs12577383 chr11:47774238 C/T cg20307385 chr11:47447363 PSMC3 0.81 12.4 0.56 2.75e-29 Diastolic blood pressure;Systolic blood pressure; LUSC trans rs236907 0.859 rs2143369 chr1:171767372 A/G cg13482142 chr2:234261155 NA 0.49 6.16 0.32 2.09e-9 Mean platelet volume; LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg04944784 chr2:26401820 FAM59B -0.77 -11.41 -0.53 1.12e-25 Gut microbiome composition (summer); LUSC cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg00677455 chr12:58241039 CTDSP2 -0.59 -8.53 -0.42 5.25e-16 Multiple sclerosis; LUSC cis rs7119 0.717 rs11632729 chr15:77722006 G/A cg05673287 chr15:77411982 SGK269 -0.43 -6.73 -0.35 7.53e-11 Type 2 diabetes; LUSC cis rs1577917 1.000 rs35385043 chr6:86648546 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg14092988 chr3:52407081 DNAH1 0.33 6.42 0.33 4.7e-10 Bipolar disorder; LUSC cis rs3857536 0.740 rs4710574 chr6:66890631 T/G cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs28830936 0.510 rs7175346 chr15:42100674 G/A cg17847044 chr15:42102381 MAPKBP1 -0.38 -9.34 -0.46 1.35e-18 Diastolic blood pressure; LUSC cis rs3136441 0.892 rs4752936 chr11:46821078 A/C cg01183595 chr11:46746236 F2 0.36 5.77 0.3 1.81e-8 HDL cholesterol; LUSC trans rs12210905 0.688 rs12374607 chr6:27343620 A/G cg02699829 chr19:13216355 TRMT1 -0.56 -6.23 -0.32 1.39e-9 Hip circumference adjusted for BMI; LUSC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg18404041 chr3:52824283 ITIH1 0.42 7.23 0.37 3.38e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9311676 0.632 rs7610312 chr3:58374029 A/G cg13750441 chr3:58318267 PXK 0.36 6.93 0.35 2.12e-11 Systemic lupus erythematosus; LUSC cis rs9399135 0.967 rs9389256 chr6:135331254 A/C cg22676075 chr6:135203613 NA 0.48 7.61 0.38 2.8e-13 Red blood cell count; LUSC cis rs7246967 0.673 rs2099341 chr19:22834360 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs738322 0.967 rs2092180 chr22:38571563 A/G cg17652424 chr22:38574118 PLA2G6 -0.29 -6.41 -0.33 5e-10 Cutaneous nevi; LUSC cis rs2797160 0.967 rs1578793 chr6:126015057 A/G cg05901451 chr6:126070800 HEY2 0.57 8.65 0.43 2.22e-16 Endometrial cancer; LUSC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg11843238 chr5:131593191 PDLIM4 0.44 7.75 0.39 1.14e-13 Blood metabolite levels; LUSC cis rs4930561 0.739 rs7118045 chr11:67978734 C/G cg04465784 chr11:67976953 SUV420H1 -0.28 -5.65 -0.3 3.48e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs2997447 0.706 rs2783713 chr1:26429351 C/A cg19633962 chr1:26362018 EXTL1 -0.48 -5.71 -0.3 2.43e-8 QRS complex (12-leadsum); LUSC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg19230755 chr7:65878503 NA -0.43 -6.15 -0.32 2.16e-9 Aortic root size; LUSC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.49 8.16 0.41 6.89e-15 Intelligence (multi-trait analysis); LUSC cis rs11252926 0.545 rs11252693 chr10:532139 A/G cg03684893 chr10:554711 DIP2C -0.43 -8.05 -0.4 1.5e-14 Psychosis in Alzheimer's disease; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg16405210 chr4:1374714 KIAA1530 -0.82 -14.08 -0.61 1.18e-35 Longevity; LUSC cis rs1568889 0.592 rs17652117 chr11:28483645 C/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.51 -6.45 -0.33 3.88e-10 Bipolar disorder; LUSC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg18876405 chr7:65276391 NA -0.73 -12.74 -0.57 1.38e-30 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04696171 chr16:89787876 C16orf7;ZNF276 -0.54 -6.86 -0.35 3.35e-11 Bipolar disorder and schizophrenia; LUSC cis rs7267979 0.844 rs2474780 chr20:25285835 G/A cg14121845 chr20:25566513 NINL 0.31 5.77 0.3 1.81e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg01065977 chr19:18549689 ISYNA1 -0.23 -5.94 -0.31 7.17e-9 Breast cancer; LUSC cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg04455712 chr21:45112962 RRP1B 0.46 8.67 0.43 1.85e-16 Mean corpuscular volume; LUSC trans rs1728785 0.892 rs9928950 chr16:68557114 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.59 -6.98 -0.36 1.64e-11 Ulcerative colitis; LUSC cis rs9303401 0.659 rs12952325 chr17:56899371 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.89 0.61 6.16e-35 Cognitive test performance; LUSC cis rs11608355 0.618 rs60819157 chr12:109795766 G/A cg19025524 chr12:109796872 NA -0.48 -9.16 -0.45 5.46e-18 Neuroticism; LUSC cis rs17253792 0.822 rs79747476 chr14:56160485 C/A cg01858014 chr14:56050164 KTN1 -0.85 -6.82 -0.35 4.21e-11 Putamen volume; LUSC cis rs4343996 0.727 rs12537528 chr7:3375910 A/G cg21248987 chr7:3385318 SDK1 0.33 5.65 0.3 3.45e-8 Motion sickness; LUSC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg06112835 chr11:68658793 MRPL21 0.51 7.82 0.39 7.13e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.63 0.86 5.12e-99 Chronic sinus infection; LUSC cis rs7937890 0.904 rs7484197 chr11:14283654 C/T cg02886208 chr11:14281011 SPON1 -0.32 -5.75 -0.3 2.01e-8 Mitochondrial DNA levels; LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg06718696 chr17:78121285 EIF4A3 0.78 11.61 0.54 2.07e-26 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs7599312 0.553 rs6710653 chr2:213404893 A/G cg20637307 chr2:213403960 ERBB4 0.44 7.51 0.38 5.38e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7312933 0.558 rs1796394 chr12:42826359 G/A cg01256987 chr12:42539512 GXYLT1 0.36 6.59 0.34 1.71e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1448094 1.000 rs10083080 chr12:86348579 G/C cg02569458 chr12:86230093 RASSF9 0.41 6.58 0.34 1.77e-10 Major depressive disorder; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg16606324 chr3:10149918 C3orf24 0.68 9.86 0.47 2.63e-20 Alzheimer's disease; LUSC cis rs6723226 0.698 rs13409142 chr2:32666137 C/T cg02381751 chr2:32503542 YIPF4 0.57 8.39 0.42 1.35e-15 Intelligence (multi-trait analysis); LUSC cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg24642439 chr20:33292090 TP53INP2 0.5 7.5 0.38 5.92e-13 Glomerular filtration rate (creatinine); LUSC cis rs9399135 0.967 rs11754783 chr6:135347661 T/A cg22676075 chr6:135203613 NA 0.47 7.4 0.38 1.12e-12 Red blood cell count; LUSC cis rs6840360 0.571 rs4696098 chr4:152489053 C/T cg22705602 chr4:152727874 NA -0.33 -6.67 -0.34 1.08e-10 Intelligence (multi-trait analysis); LUSC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg12863693 chr15:85201151 NMB 0.27 5.95 0.31 6.74e-9 P wave terminal force; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg02353165 chr6:42928485 GNMT 0.67 11.6 0.54 2.2e-26 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2115536 0.730 rs4573897 chr15:80187225 G/A cg00225070 chr15:80189496 MTHFS 0.43 6.37 0.33 6.41e-10 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 9.42 0.46 7.89e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7149337 0.717 rs4309324 chr14:51606336 A/T cg23942311 chr14:51606299 NA -0.62 -14.83 -0.63 1.43e-38 Cancer; LUSC cis rs7267979 0.932 rs2260997 chr20:25256266 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.21 -0.72 6.43e-56 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg03146154 chr1:46216737 IPP 0.52 7.6 0.38 3.01e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg19077165 chr18:44547161 KATNAL2 -0.45 -6.75 -0.35 6.74e-11 Personality dimensions; LUSC cis rs7089973 0.872 rs7918253 chr10:116614501 T/C cg23260525 chr10:116636907 FAM160B1 0.4 8.24 0.41 3.88e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg14844989 chr11:31128820 NA 0.38 6.17 0.32 1.93e-9 Red blood cell count; LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg20607798 chr8:58055168 NA 0.49 5.92 0.31 8.14e-9 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.690 rs7132879 chr12:86289864 A/G cg00310523 chr12:86230176 RASSF9 0.47 8.48 0.42 7.39e-16 Major depressive disorder; LUSC cis rs1371867 0.846 rs2919469 chr8:101233896 C/T cg00191853 chr8:101177733 SPAG1 -0.39 -6.43 -0.33 4.3e-10 Atrioventricular conduction; LUSC cis rs6429082 0.755 rs291384 chr1:235644300 C/T cg26050004 chr1:235667680 B3GALNT2 0.61 8.37 0.42 1.58e-15 Adiposity; LUSC cis rs2970818 0.831 rs73037770 chr12:4637864 G/T cg11146114 chr12:4671731 NA -0.59 -5.88 -0.31 1.01e-8 Phosphorus levels; LUSC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs7944735 0.507 rs10838802 chr11:48102478 A/G cg03929089 chr4:120376271 NA 0.54 6.79 0.35 5e-11 Intraocular pressure; LUSC cis rs12579753 0.917 rs6539580 chr12:82184765 T/C cg21231944 chr12:82153410 PPFIA2 -0.37 -5.68 -0.3 2.88e-8 Resting heart rate; LUSC cis rs9811920 0.770 rs4928237 chr3:99731330 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.6 -0.34 1.6e-10 Axial length; LUSC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC trans rs7615952 0.599 rs1044215 chr3:125725559 C/G cg07211511 chr3:129823064 LOC729375 -0.83 -11.96 -0.55 1.14e-27 Blood pressure (smoking interaction); LUSC cis rs9929218 0.529 rs35854485 chr16:68730855 C/G cg01251360 chr16:68772225 CDH1 -0.26 -6.05 -0.31 3.95e-9 Colorectal cancer; LUSC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.37 6.0 0.31 5.11e-9 Self-reported allergy; LUSC cis rs7180079 0.620 rs2101225 chr15:64731679 G/A cg08069370 chr15:64387884 SNX1 0.51 5.65 0.3 3.41e-8 Monocyte count; LUSC cis rs1538970 0.962 rs7532762 chr1:45864695 C/A cg05343316 chr1:45956843 TESK2 0.62 9.01 0.44 1.62e-17 Platelet count; LUSC cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.53 -0.42 5.32e-16 Body mass index; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC cis rs1018836 0.786 rs10956736 chr8:91602067 C/T cg16814680 chr8:91681699 NA -0.7 -11.35 -0.53 1.74e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs977987 0.806 rs4993970 chr16:75411619 G/A cg03315344 chr16:75512273 CHST6 0.49 9.32 0.45 1.6e-18 Dupuytren's disease; LUSC cis rs75804782 0.521 rs55690022 chr2:239407783 C/T cg18131467 chr2:239335373 ASB1 -0.68 -6.28 -0.33 1.03e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs7759001 0.857 rs2223463 chr6:27356193 G/C cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg18876405 chr7:65276391 NA -0.54 -8.45 -0.42 8.88e-16 Aortic root size; LUSC cis rs4889855 0.556 rs4890043 chr17:78526831 C/T cg16591659 chr17:78472290 NA 0.31 5.76 0.3 1.88e-8 Fractional excretion of uric acid; LUSC cis rs1609391 0.561 rs9289523 chr3:136635589 C/G cg15507776 chr3:136538369 TMEM22 0.53 8.71 0.43 1.38e-16 Neuroticism; LUSC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg09703963 chr11:616879 IRF7;MUPCDH -0.45 -7.15 -0.36 5.4e-12 Systemic lupus erythematosus; LUSC cis rs1997103 1.000 rs2009441 chr7:55405989 A/G cg17469321 chr7:55412551 NA 0.66 10.62 0.5 6.87e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg05868516 chr6:26286170 HIST1H4H 0.37 6.07 0.32 3.38e-9 Educational attainment; LUSC cis rs644799 0.526 rs693172 chr11:95636618 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.59 8.87 0.44 4.45e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg01879757 chr17:41196368 BRCA1 -0.48 -7.57 -0.38 3.62e-13 Menopause (age at onset); LUSC trans rs7726839 0.561 rs72703050 chr5:582917 A/C cg25482853 chr8:67687455 SGK3 1.03 15.45 0.65 5.41e-41 Obesity-related traits; LUSC cis rs17253792 0.822 rs10148122 chr14:56146694 G/T cg01858014 chr14:56050164 KTN1 -0.82 -7.11 -0.36 7.29e-12 Putamen volume; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg04975205 chr1:24127260 GALE 0.39 6.25 0.32 1.27e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs11214589 0.747 rs7939992 chr11:113229665 T/C cg14159747 chr11:113255604 NA 0.24 5.83 0.3 1.31e-8 Neuroticism; LUSC cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg06784218 chr1:46089804 CCDC17 0.53 10.53 0.5 1.4e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4141404 0.851 rs8135417 chr22:31559255 G/A cg13145458 chr22:31556086 RNF185 0.44 5.75 0.3 2.04e-8 Paclitaxel-induced neuropathy; LUSC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.8 -0.39 8.23e-14 Bipolar disorder; LUSC cis rs2985684 0.894 rs7152110 chr14:50018218 T/C cg04989706 chr14:50066350 PPIL5 -0.45 -6.01 -0.31 4.9e-9 Carotid intima media thickness; LUSC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg26695010 chr11:65641043 EFEMP2 -0.47 -6.86 -0.35 3.43e-11 Eosinophil percentage of white cells; LUSC cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg06462663 chr19:18546047 ISYNA1 0.45 7.45 0.38 8e-13 Breast cancer; LUSC cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg01689657 chr7:91764605 CYP51A1 0.33 6.05 0.31 3.98e-9 Breast cancer; LUSC cis rs151234 0.741 rs151229 chr16:28584937 G/A cg01378222 chr16:28622494 SULT1A1 -0.63 -8.53 -0.42 5.08e-16 Platelet distribution width; LUSC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs12493885 0.769 rs61791510 chr3:153754666 G/T cg17054900 chr3:154042577 DHX36 -0.67 -7.06 -0.36 9.76e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs847577 0.609 rs7791463 chr7:97819047 G/A cg24562669 chr7:97807699 LMTK2 0.48 8.56 0.42 4.18e-16 Breast cancer; LUSC cis rs727505 1.000 rs28844358 chr7:124562695 A/C cg23710748 chr7:124431027 NA -0.41 -7.44 -0.38 8.67e-13 Lewy body disease; LUSC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg11062466 chr8:58055876 NA 0.68 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg10645314 chr2:3704589 ALLC -0.47 -7.18 -0.37 4.47e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7809950 0.784 rs7803102 chr7:107248929 T/G cg23024343 chr7:107201750 COG5 0.55 8.59 0.43 3.38e-16 Coronary artery disease; LUSC trans rs11098499 0.954 rs2389803 chr4:120393511 A/G cg25214090 chr10:38739885 LOC399744 -0.53 -7.83 -0.39 6.71e-14 Corneal astigmatism; LUSC cis rs9329289 0.510 rs11251283 chr10:2555784 C/G cg15501526 chr10:2543763 NA 0.53 9.29 0.45 2.1e-18 Age-related hearing impairment; LUSC cis rs2204008 0.540 rs3908193 chr12:38410907 G/T cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.77e-15 Bladder cancer; LUSC cis rs9486715 1.000 rs9386670 chr6:97060688 C/A cg06623918 chr6:96969491 KIAA0776 -0.87 -13.99 -0.61 2.62e-35 Headache; LUSC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs1153858 1.000 rs28679834 chr15:45616206 C/T cg21132104 chr15:45694354 SPATA5L1 0.59 8.19 0.41 5.77e-15 Homoarginine levels; LUSC cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg03676636 chr4:99064102 C4orf37 0.36 8.07 0.4 1.27e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg01579765 chr21:45077557 HSF2BP -0.52 -10.85 -0.51 1.06e-23 Mean corpuscular volume; LUSC cis rs7605378 1.000 rs2689766 chr2:200697539 A/T cg23649088 chr2:200775458 C2orf69 0.53 8.18 0.41 6.16e-15 Osteoporosis; LUSC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg03060546 chr3:49711283 APEH -0.68 -9.99 -0.48 1.02e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs6964587 1.000 rs12539231 chr7:91634963 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.78 0.3 1.69e-8 Breast cancer; LUSC cis rs77633900 0.614 rs2468122 chr15:76918686 A/C cg21673338 chr15:77095150 SCAPER -0.66 -6.73 -0.35 7.61e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg08888203 chr3:10149979 C3orf24 0.65 9.04 0.44 1.34e-17 Alzheimer's disease; LUSC cis rs27434 0.561 rs151910 chr5:96156956 C/A cg16492584 chr5:96139282 ERAP1 -0.57 -7.61 -0.38 2.89e-13 Ankylosing spondylitis; LUSC cis rs2455601 0.786 rs56680262 chr11:8971555 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -8.17 -0.41 6.61e-15 Schizophrenia; LUSC cis rs10754283 0.756 rs17441836 chr1:90135433 C/T cg21401794 chr1:90099060 LRRC8C 0.55 8.01 0.4 1.88e-14 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7267979 0.903 rs2474766 chr20:25246153 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.4 0.71 1.02e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs262150 0.659 rs2730275 chr7:158793397 A/G cg09640425 chr7:158790006 NA -0.53 -8.27 -0.41 3.2e-15 Facial morphology (factor 20); LUSC cis rs6665290 0.582 rs72764213 chr1:227207391 C/T cg10327440 chr1:227177885 CDC42BPA -1.22 -40.38 -0.91 1.44e-130 Myeloid white cell count; LUSC cis rs62400317 0.826 rs4544895 chr6:45271917 A/T cg18551225 chr6:44695536 NA -0.42 -6.95 -0.36 1.89e-11 Total body bone mineral density; LUSC cis rs3764021 0.870 rs2192437 chr12:9879235 T/A cg20894963 chr12:9885564 CLECL1 0.34 6.85 0.35 3.58e-11 Type 1 diabetes; LUSC cis rs4285028 0.948 rs6790281 chr3:121665543 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.75 -0.47 6.2e-20 Multiple sclerosis; LUSC cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg17063962 chr7:91808500 NA 0.55 8.26 0.41 3.48e-15 Breast cancer; LUSC cis rs2304069 0.954 rs6861548 chr5:149384680 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.8 11.11 0.52 1.33e-24 HIV-1 control; LUSC trans rs1493916 0.655 rs4534926 chr18:31349072 G/C cg27147174 chr7:100797783 AP1S1 -0.64 -10.31 -0.49 8.31e-22 Life satisfaction; LUSC cis rs897984 0.542 rs3751855 chr16:31091209 T/C cg02466173 chr16:30829666 NA -0.5 -9.55 -0.46 2.91e-19 Dementia with Lewy bodies; LUSC cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.53 -7.99 -0.4 2.25e-14 Axial length; LUSC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg06074448 chr4:187884817 NA -0.41 -6.89 -0.35 2.85e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6691722 0.503 rs1142057 chr1:24706292 C/T cg18323236 chr1:24743029 NIPAL3 -0.36 -5.79 -0.3 1.63e-8 Response to interferon beta in multiple sclerosis; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg07562458 chr1:224622430 WDR26 -0.46 -6.56 -0.34 2.09e-10 Cognitive function;Information processing speed; LUSC cis rs714027 0.585 rs2007446 chr22:30388601 C/T cg11564601 chr22:30592435 NA 0.34 5.82 0.3 1.38e-8 Lymphocyte counts; LUSC cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg24450063 chr1:156163899 SLC25A44 -1.17 -29.86 -0.85 2.67e-96 Testicular germ cell tumor; LUSC cis rs12999616 0.696 rs56035334 chr2:98329047 T/G cg26665480 chr2:98280029 ACTR1B 0.52 5.93 0.31 7.76e-9 Colorectal cancer; LUSC cis rs11711311 1.000 rs2566968 chr3:113474154 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.93 0.35 2.16e-11 IgG glycosylation; LUSC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg24399712 chr22:39784796 NA -0.63 -11.5 -0.53 5.01e-26 Intelligence (multi-trait analysis); LUSC cis rs7605827 0.930 rs9287661 chr2:15595901 G/A cg19274914 chr2:15703543 NA 0.46 8.73 0.43 1.2e-16 Educational attainment (years of education); LUSC cis rs2629540 0.847 rs34032724 chr10:126408869 T/G cg08799069 chr10:126477246 METTL10 0.6 8.24 0.41 3.98e-15 Cocaine dependence; LUSC trans rs2204008 0.811 rs11520277 chr12:38359611 G/A cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.28e-9 Bladder cancer; LUSC cis rs11997175 0.653 rs7005254 chr8:33641781 A/T ch.8.33884649F chr8:33765107 NA 0.47 7.48 0.38 6.64e-13 Body mass index; LUSC cis rs3820928 0.874 rs4675138 chr2:227884118 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.78 -0.39 9.39e-14 Pulmonary function; LUSC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg15704280 chr7:45808275 SEPT13 0.99 16.55 0.67 2.35e-45 Coronary artery disease; LUSC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg13939156 chr17:80058883 NA 0.34 6.61 0.34 1.52e-10 Life satisfaction; LUSC cis rs2290159 0.800 rs6792773 chr3:12668726 C/T cg23032965 chr3:12705835 RAF1 0.74 9.11 0.45 7.89e-18 Cholesterol, total; LUSC cis rs7824557 0.628 rs3174048 chr8:11184937 G/A cg21293242 chr8:11204541 TDH 0.34 6.38 0.33 6.01e-10 Retinal vascular caliber; LUSC cis rs7100689 0.725 rs2487074 chr10:82064104 A/G cg01528321 chr10:82214614 TSPAN14 0.98 14.61 0.62 9.9e-38 Post bronchodilator FEV1; LUSC cis rs7584330 0.738 rs4402703 chr2:238374957 T/A cg14458575 chr2:238380390 NA 0.66 11.37 0.53 1.48e-25 Prostate cancer; LUSC trans rs7824557 0.628 rs2572387 chr8:11204165 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.76 0.35 6.1e-11 Retinal vascular caliber; LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg09436375 chr6:42928200 GNMT -0.29 -6.74 -0.35 7.01e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg26338869 chr17:61819248 STRADA 0.42 6.09 0.32 3.11e-9 Prudent dietary pattern; LUSC cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg16006841 chr5:176797999 RGS14 0.62 8.69 0.43 1.6e-16 Urate levels in lean individuals; LUSC cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg05347473 chr6:146136440 FBXO30 0.53 9.06 0.44 1.13e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9300255 0.596 rs7304782 chr12:123719444 A/G cg05973401 chr12:123451056 ABCB9 -0.52 -7.22 -0.37 3.58e-12 Neutrophil percentage of white cells; LUSC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg19468946 chr17:37922297 IKZF3 -0.44 -6.92 -0.35 2.36e-11 Self-reported allergy; LUSC cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.96 0.7 5.97e-51 Chronic sinus infection; LUSC cis rs6977660 0.714 rs10236607 chr7:19818620 A/G cg07541023 chr7:19748670 TWISTNB 0.59 6.36 0.33 6.62e-10 Thyroid stimulating hormone; LUSC cis rs6456156 0.774 rs6931530 chr6:167527200 A/C cg07741184 chr6:167504864 NA -0.36 -6.34 -0.33 7.54e-10 Primary biliary cholangitis; LUSC cis rs4293296 0.525 rs12323811 chr14:54811735 C/A cg02257953 chr14:54816093 NA -0.44 -6.49 -0.33 3.15e-10 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs1949733 0.628 rs1543246 chr4:8504909 A/T cg11789530 chr4:8429930 ACOX3 0.53 7.84 0.39 5.91e-14 Response to antineoplastic agents; LUSC trans rs10221833 0.602 rs355883 chr2:165633925 A/T cg26993132 chr16:89239499 CDH15 0.31 5.98 0.31 5.64e-9 Response to statin therapy; LUSC cis rs7681440 0.583 rs2736993 chr4:90772851 A/C cg06632027 chr4:90757378 SNCA -0.37 -5.8 -0.3 1.54e-8 Dementia with Lewy bodies; LUSC cis rs60843830 1.000 rs2126129 chr2:212548 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.98 0.4 2.31e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05901451 chr6:126070800 HEY2 -0.79 -14.15 -0.61 6.28e-36 Brugada syndrome; LUSC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg23630131 chr7:65973040 NA -0.21 -5.82 -0.3 1.38e-8 Aortic root size; LUSC cis rs7113850 0.541 rs7927067 chr11:24232604 G/A ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Bone fracture in osteoporosis; LUSC cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg13319975 chr6:146136371 FBXO30 0.49 7.55 0.38 4.15e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg02018176 chr4:1364513 KIAA1530 0.48 8.32 0.41 2.22e-15 Obesity-related traits; LUSC cis rs7592578 0.679 rs62181020 chr2:191325601 A/C cg10560079 chr2:191398806 TMEM194B -0.66 -8.3 -0.41 2.61e-15 Diastolic blood pressure; LUSC cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg03146154 chr1:46216737 IPP 0.57 8.47 0.42 8e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg03233332 chr7:66118400 NA -0.42 -6.14 -0.32 2.33e-9 Aortic root size; LUSC cis rs7113850 0.541 rs114370606 chr11:24232247 C/T ch.11.24196551F chr11:24239977 NA 0.99 9.08 0.44 1e-17 Bone fracture in osteoporosis; LUSC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs208520 0.955 rs12204033 chr6:67001525 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.82 10.14 0.49 3.14e-21 Exhaled nitric oxide output; LUSC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.57 -0.34 1.94e-10 Schizophrenia; LUSC cis rs12824058 0.737 rs873663 chr12:130816316 C/T cg23887609 chr12:130822674 PIWIL1 0.45 6.29 0.33 9.93e-10 Menopause (age at onset); LUSC trans rs11989744 0.597 rs11135768 chr8:23573278 A/G cg03492747 chr16:86543808 FOXF1 0.61 10.24 0.49 1.44e-21 Waist-hip ratio; LUSC cis rs2882667 0.690 rs176382 chr5:138226767 A/G cg04439458 chr5:138467593 SIL1 -0.38 -7.43 -0.38 8.95e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10089 0.953 rs758180 chr5:127354423 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.82 11.42 0.53 1.05e-25 Ileal carcinoids; LUSC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg08085267 chr17:45401833 C17orf57 -0.62 -10.47 -0.5 2.2e-22 Multiple sclerosis;Ankylosing spondylitis; LUSC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg25554036 chr4:6271136 WFS1 -0.56 -11.87 -0.54 2.36e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4619890 0.528 rs28622214 chr4:7879440 C/T cg24250820 chr4:7887609 AFAP1 0.36 6.16 0.32 2.06e-9 Glaucoma (primary open-angle); LUSC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg09491104 chr22:46646882 C22orf40 -0.64 -7.29 -0.37 2.33e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs1372520 0.684 rs2197120 chr4:90729602 A/G cg01966878 chr4:90757139 SNCA -0.43 -6.22 -0.32 1.49e-9 Neuroticism; LUSC cis rs11191205 0.774 rs11191203 chr10:103824920 C/T cg15320455 chr10:103880129 LDB1 0.52 5.93 0.31 7.56e-9 Intelligence (multi-trait analysis); LUSC cis rs6964587 0.621 rs38798 chr7:92044539 C/A cg17063962 chr7:91808500 NA -0.49 -7.35 -0.37 1.5e-12 Breast cancer; LUSC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs13427251 0.653 rs11123787 chr2:100156940 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.8 -0.35 4.71e-11 Chronic sinus infection; LUSC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg17366294 chr4:99064904 C4orf37 0.6 10.58 0.5 9.38e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg22903471 chr2:27725779 GCKR -0.41 -7.07 -0.36 9.12e-12 Total body bone mineral density; LUSC cis rs939658 0.935 rs954292 chr15:79449237 C/T cg17916960 chr15:79447300 NA 0.48 9.76 0.47 5.81e-20 Refractive error; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg07362569 chr17:61921086 SMARCD2 0.37 7.66 0.39 2.05e-13 Prudent dietary pattern; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -7.96 -0.4 2.67e-14 Lymphocyte counts; LUSC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg05535760 chr7:792225 HEATR2 -0.79 -8.97 -0.44 2.11e-17 Cerebrospinal P-tau181p levels; LUSC cis rs10911251 0.508 rs729672 chr1:183109236 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.56 0.5 1.08e-22 Colorectal cancer; LUSC cis rs12980942 0.591 rs11879429 chr19:41757444 G/A cg25627403 chr19:41769009 HNRNPUL1 0.7 7.36 0.37 1.42e-12 Coronary artery disease; LUSC cis rs1448094 0.967 rs10047659 chr12:86338278 C/A cg02569458 chr12:86230093 RASSF9 0.42 6.85 0.35 3.49e-11 Major depressive disorder; LUSC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg06544989 chr22:39130855 UNC84B 0.37 6.36 0.33 6.53e-10 Menopause (age at onset); LUSC cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg04450456 chr4:17643702 FAM184B 0.38 6.24 0.32 1.31e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs68170813 0.617 rs17481842 chr7:107121862 C/T cg02696742 chr7:106810147 HBP1 -0.63 -8.25 -0.41 3.76e-15 Coronary artery disease; LUSC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg26061582 chr7:22766209 IL6 0.48 6.9 0.35 2.61e-11 Lung cancer; LUSC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg17554472 chr22:41940697 POLR3H 0.49 5.98 0.31 5.86e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12594515 1.000 rs6493172 chr15:45987213 T/G cg01629716 chr15:45996671 NA 0.4 6.12 0.32 2.56e-9 Waist circumference;Weight; LUSC cis rs7296418 0.961 rs1790106 chr12:123591596 G/T cg05973401 chr12:123451056 ABCB9 0.64 9.29 0.45 1.98e-18 Platelet count; LUSC cis rs7809950 0.954 rs2894466 chr7:107242909 G/A cg23024343 chr7:107201750 COG5 0.57 9.02 0.44 1.54e-17 Coronary artery disease; LUSC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.53e-10 Life satisfaction; LUSC cis rs10493773 0.609 rs12058974 chr1:86192235 T/A cg17807903 chr1:86174739 ZNHIT6 -0.54 -14.93 -0.63 5.86e-39 Urate levels in overweight individuals; LUSC cis rs8005677 1.000 rs11157930 chr14:23403171 T/G cg00579484 chr14:23475993 C14orf93 0.39 5.66 0.3 3.23e-8 Cognitive ability (multi-trait analysis); LUSC cis rs861020 0.771 rs126280 chr1:210019824 A/G cg09163369 chr1:210001066 C1orf107 0.5 6.02 0.31 4.7e-9 Orofacial clefts; LUSC cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg18252515 chr7:66147081 NA -1.23 -13.8 -0.6 1.39e-34 Diabetic kidney disease; LUSC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg06671706 chr8:8559999 CLDN23 0.5 6.83 0.35 4.14e-11 Obesity-related traits; LUSC cis rs6665290 0.904 rs11587443 chr1:227187896 T/C cg10327440 chr1:227177885 CDC42BPA -1.21 -40.08 -0.91 1.14e-129 Myeloid white cell count; LUSC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg18876405 chr7:65276391 NA -0.58 -9.36 -0.46 1.22e-18 Aortic root size; LUSC cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg08085267 chr17:45401833 C17orf57 -0.54 -8.17 -0.41 6.34e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8062405 0.690 rs762634 chr16:28603335 T/C cg07382826 chr16:28625726 SULT1A1 0.28 6.07 0.32 3.47e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg03146154 chr1:46216737 IPP 0.49 7.35 0.37 1.49e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg01884057 chr2:25150051 NA 0.48 11.42 0.53 1e-25 Body mass index; LUSC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg05802129 chr4:122689817 NA -0.52 -8.77 -0.43 9.01e-17 Type 2 diabetes; LUSC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg13057898 chr1:3703894 LRRC47 0.51 9.16 0.45 5.47e-18 Red cell distribution width; LUSC trans rs7181230 1.000 rs28587891 chr15:40365106 T/A cg22705835 chr10:65332833 REEP3 -0.43 -7.34 -0.37 1.65e-12 Dehydroepiandrosterone sulphate levels; LUSC trans rs4714291 0.963 rs761801 chr6:39997176 G/A cg02267698 chr19:7991119 CTXN1 0.52 7.3 0.37 2.06e-12 Strep throat; LUSC cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.83 -0.43 6.13e-17 Monocyte percentage of white cells; LUSC cis rs3106136 0.527 rs2865345 chr4:95156565 A/G cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.48 -0.42 7.38e-16 Capecitabine sensitivity; LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 6.83 0.35 3.93e-11 Bipolar disorder; LUSC cis rs9300255 0.739 rs1402275 chr12:123750895 A/G cg05973401 chr12:123451056 ABCB9 0.56 6.85 0.35 3.49e-11 Neutrophil percentage of white cells; LUSC cis rs6121246 0.567 rs6060247 chr20:30190720 C/G cg21427119 chr20:30132790 HM13 -0.44 -6.34 -0.33 7.29e-10 Mean corpuscular hemoglobin; LUSC cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg23788917 chr6:8435910 SLC35B3 0.51 7.56 0.38 3.86e-13 Motion sickness; LUSC cis rs17034641 1.000 rs10495930 chr2:46372675 A/G cg12428440 chr2:46370979 PRKCE 0.46 6.15 0.32 2.17e-9 Hemoglobin;Hematocrit; LUSC cis rs9309473 0.579 rs6728128 chr2:73595982 T/C cg20560298 chr2:73613845 ALMS1 -0.56 -8.25 -0.41 3.76e-15 Metabolite levels; LUSC cis rs9329221 0.736 rs34381075 chr8:10243785 C/G cg21775007 chr8:11205619 TDH 0.49 6.52 0.34 2.57e-10 Neuroticism; LUSC cis rs9326248 0.581 rs10892072 chr11:116960313 G/A cg01368799 chr11:117014884 PAFAH1B2 0.58 8.87 0.44 4.4e-17 Blood protein levels; LUSC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.65 0.39 2.21e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.7 -10.7 -0.51 3.51e-23 Platelet count; LUSC cis rs7216064 0.953 rs10445361 chr17:65962238 G/T cg12091567 chr17:66097778 LOC651250 0.66 9.0 0.44 1.76e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.42 0.42 1.11e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs8180040 0.966 rs807932 chr3:47354241 C/T cg02527881 chr3:46936655 PTH1R -0.42 -7.49 -0.38 6.18e-13 Colorectal cancer; LUSC cis rs1670533 0.932 rs10902753 chr4:1056223 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.05 0.31 3.91e-9 Recombination rate (females); LUSC cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg25233709 chr10:116636983 FAM160B1 0.45 8.12 0.41 9.24e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs16895831 0.519 rs16895843 chr6:42541802 G/C cg10605015 chr6:42532144 UBR2 -0.5 -5.95 -0.31 6.67e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs9788721 0.836 rs2009746 chr15:78754102 A/G cg18825076 chr15:78729989 IREB2 -0.6 -9.94 -0.48 1.47e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6489882 0.807 rs61266553 chr12:113371977 A/G cg20102336 chr12:113376681 OAS3 -0.42 -6.1 -0.32 2.9e-9 Chronic lymphocytic leukemia; LUSC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.49 7.77 0.39 9.83e-14 Menarche (age at onset); LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.41 5.78 0.3 1.74e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs6547741 1.000 rs10205364 chr2:27794233 C/T cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 3.04e-39 Oral cavity cancer; LUSC cis rs611744 0.870 rs596703 chr8:109160146 A/G cg18478394 chr8:109455254 TTC35 -0.43 -6.42 -0.33 4.63e-10 Dupuytren's disease; LUSC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11644478 chr21:40555479 PSMG1 0.94 18.8 0.72 2.63e-54 Cognitive function; LUSC trans rs208520 1.000 rs72884025 chr6:66994185 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 11.93 0.55 1.4e-27 Exhaled nitric oxide output; LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg23758822 chr17:41437982 NA 1.05 19.67 0.73 9.29e-58 Menopause (age at onset); LUSC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg23758822 chr17:41437982 NA 1.05 20.56 0.75 2.89e-61 Menopause (age at onset); LUSC cis rs9399135 0.660 rs4472368 chr6:135274232 A/G cg22676075 chr6:135203613 NA 0.52 8.3 0.41 2.68e-15 Red blood cell count; LUSC cis rs17685 0.697 rs2302437 chr7:75677016 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.52 8.06 0.4 1.41e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg05552183 chr6:42928497 GNMT 0.52 8.59 0.43 3.29e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg11766577 chr21:47581405 C21orf56 0.57 8.77 0.43 9.37e-17 Testicular germ cell tumor; LUSC cis rs7809950 0.817 rs10224503 chr7:107075569 A/C cg23024343 chr7:107201750 COG5 -0.68 -9.96 -0.48 1.28e-20 Coronary artery disease; LUSC cis rs2637266 0.678 rs1797495 chr10:78577602 G/A cg18941641 chr10:78392320 NA 0.32 5.71 0.3 2.55e-8 Pulmonary function; LUSC cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg02820040 chr2:241836501 C2orf54 0.27 5.79 0.3 1.58e-8 Urinary metabolites; LUSC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Urate levels; LUSC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg04362960 chr10:104952993 NT5C2 0.59 9.47 0.46 5.32e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2806561 0.765 rs643492 chr1:23501354 C/T cg12483005 chr1:23474871 LUZP1 -0.41 -6.33 -0.33 7.86e-10 Height; LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg07507251 chr3:52567010 NT5DC2 0.33 6.38 0.33 5.99e-10 Bipolar disorder; LUSC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg03146154 chr1:46216737 IPP 0.49 7.37 0.37 1.39e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3540 0.512 rs11633872 chr15:91080512 G/A cg10434728 chr15:90938212 IQGAP1 -0.46 -9.34 -0.46 1.4e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg15423357 chr2:25149977 NA 0.44 8.97 0.44 2.11e-17 Body mass index; LUSC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg11764359 chr7:65958608 NA -0.62 -9.45 -0.46 6.04e-19 Aortic root size; LUSC cis rs2692947 0.702 rs7604842 chr2:96777340 C/T cg22654517 chr2:96458247 NA -0.32 -5.88 -0.31 9.97e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9815354 0.812 rs73830532 chr3:41898814 T/C cg03022575 chr3:42003672 ULK4 0.84 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs6582630 0.502 rs11522899 chr12:38270637 T/C cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs7106204 0.609 rs12790279 chr11:24286221 C/G ch.11.24196551F chr11:24239977 NA 0.7 6.47 0.33 3.45e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7100689 0.598 rs2342815 chr10:82086532 T/C cg00277334 chr10:82204260 NA -0.58 -8.71 -0.43 1.47e-16 Post bronchodilator FEV1; LUSC cis rs7106204 0.514 rs12291514 chr11:24360203 T/C ch.11.24196551F chr11:24239977 NA 0.79 8.43 0.42 1.07e-15 Response to Homoharringtonine (cytotoxicity); LUSC cis rs28647808 0.748 rs28502181 chr9:136257792 T/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs7503807 0.967 rs7215486 chr17:78612034 C/T cg09596252 chr17:78655493 RPTOR 0.46 7.91 0.4 3.88e-14 Obesity; LUSC cis rs5770917 1.000 rs2269384 chr22:51011115 C/T cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.65 -5.7 -0.3 2.65e-8 Narcolepsy; LUSC cis rs72960926 1.000 rs72950597 chr6:74921367 T/C cg03266952 chr6:74778945 NA -0.73 -6.47 -0.33 3.56e-10 Metabolite levels (MHPG); LUSC trans rs6582630 0.519 rs12582285 chr12:38298753 C/T cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs7980799 0.649 rs11559754 chr12:33649229 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.92 -0.4 3.67e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs8060686 0.545 rs12444313 chr16:68254404 A/C cg09835421 chr16:68378352 PRMT7 -0.59 -6.31 -0.33 8.82e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs738322 0.810 rs4821764 chr22:38599364 G/A cg25457927 chr22:38595422 NA 0.48 10.03 0.48 7.15e-21 Cutaneous nevi; LUSC cis rs7833986 0.501 rs2719245 chr8:56894359 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.7 11.2 0.52 6.05e-25 Height; LUSC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg08048268 chr3:133502702 NA -0.47 -9.08 -0.44 9.95e-18 Iron status biomarkers; LUSC cis rs11677416 0.813 rs4848299 chr2:113523454 C/A cg27083787 chr2:113543245 IL1A 0.43 6.71 0.34 8.24e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs7107174 0.681 rs11237443 chr11:78005089 C/A cg02023728 chr11:77925099 USP35 0.51 7.49 0.38 6.18e-13 Testicular germ cell tumor; LUSC cis rs72781680 0.898 rs72780125 chr2:24000145 T/C cg08917208 chr2:24149416 ATAD2B 0.95 9.92 0.48 1.72e-20 Lymphocyte counts; LUSC trans rs7726839 0.540 rs11750321 chr5:599196 C/T cg11887960 chr12:57824829 NA 0.54 6.74 0.35 7.11e-11 Obesity-related traits; LUSC cis rs2446066 0.872 rs10876452 chr12:53814258 T/A cg20730629 chr12:53886622 MAP3K12 -0.4 -5.69 -0.3 2.72e-8 Red blood cell count; LUSC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg20744362 chr22:50050164 C22orf34 0.4 8.33 0.41 2.15e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg06740227 chr12:86229804 RASSF9 0.38 6.11 0.32 2.83e-9 Major depressive disorder; LUSC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg13206674 chr6:150067644 NUP43 0.61 9.64 0.47 1.46e-19 Lung cancer; LUSC cis rs2288073 1.000 rs2288073 chr2:24413298 C/T cg06627628 chr2:24431161 ITSN2 0.72 9.98 0.48 1.04e-20 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs262150 0.851 rs2657326 chr7:158766262 C/T cg09640425 chr7:158790006 NA -0.41 -6.64 -0.34 1.29e-10 Facial morphology (factor 20); LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg07701084 chr6:150067640 NUP43 0.48 6.63 0.34 1.38e-10 Testicular germ cell tumor; LUSC trans rs79976124 0.797 rs74995761 chr6:66640216 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.91 0.44 3.33e-17 Type 2 diabetes; LUSC cis rs9640161 0.830 rs3757423 chr7:150067714 A/G cg21361702 chr7:150065534 REPIN1 -0.57 -9.14 -0.45 6.33e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs6456156 0.586 rs13210649 chr6:167473193 T/G cg07741184 chr6:167504864 NA 0.4 7.01 0.36 1.3e-11 Primary biliary cholangitis; LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg17968037 chr7:100024898 ZCWPW1 -0.44 -6.38 -0.33 6.06e-10 Platelet count; LUSC cis rs2486288 0.656 rs2461705 chr15:45570241 A/G cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.51e-10 Glomerular filtration rate; LUSC cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg12935359 chr14:103987150 CKB -0.65 -10.61 -0.5 7.5e-23 Intelligence (multi-trait analysis); LUSC trans rs2204008 0.837 rs10876019 chr12:37985477 C/T cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.12e-9 Bladder cancer; LUSC cis rs6542838 0.611 rs6742047 chr2:99531460 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -6.01 -0.31 4.87e-9 Fear of minor pain; LUSC cis rs11690935 0.959 rs7586207 chr2:172671094 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.54 -0.62 1.86e-37 Schizophrenia; LUSC cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.91 -13.36 -0.59 6.62e-33 Chronic sinus infection; LUSC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg11062466 chr8:58055876 NA 0.58 7.39 0.37 1.21e-12 Developmental language disorder (linguistic errors); LUSC cis rs7712401 0.562 rs30073 chr5:122290509 A/T cg19077854 chr5:122220652 SNX24 0.44 9.9 0.48 2.02e-20 Mean platelet volume; LUSC cis rs6546886 0.912 rs13021880 chr2:74310787 C/G cg14702570 chr2:74259524 NA -0.3 -5.75 -0.3 2.05e-8 Dialysis-related mortality; LUSC cis rs3936840 0.565 rs8006911 chr14:102975265 A/G cg18135206 chr14:102964638 TECPR2 0.52 7.01 0.36 1.32e-11 Plateletcrit; LUSC trans rs3733585 0.673 rs4447861 chr4:9953940 C/T cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs748404 0.578 rs2278856 chr15:43631356 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.44 6.03 0.31 4.33e-9 Lung cancer; LUSC trans rs62458065 0.850 rs73096034 chr7:32472048 A/G cg00845942 chr12:64062724 DPY19L2 -0.53 -6.08 -0.32 3.33e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs11098499 0.908 rs28499576 chr4:120386677 G/A cg24375607 chr4:120327624 NA 0.76 11.36 0.53 1.66e-25 Corneal astigmatism; LUSC cis rs7100689 0.646 rs10887808 chr10:82137367 G/A cg00277334 chr10:82204260 NA -0.5 -7.21 -0.37 3.83e-12 Post bronchodilator FEV1; LUSC cis rs2677744 0.626 rs2001216 chr15:91498130 T/C cg20750528 chr15:91474456 HDDC3;UNC45A -0.32 -5.69 -0.3 2.75e-8 Attention deficit hyperactivity disorder; LUSC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.71 0.3 2.49e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -6.73 -0.35 7.51e-11 Major depressive disorder; LUSC cis rs12980942 0.935 rs16958996 chr19:41825138 C/T cg25627403 chr19:41769009 HNRNPUL1 0.57 6.19 0.32 1.74e-9 Coronary artery disease; LUSC cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg24692254 chr21:30365293 RNF160 -0.82 -15.21 -0.64 4.55e-40 Dental caries; LUSC cis rs754466 0.651 rs56138814 chr10:79625795 T/C cg17075019 chr10:79541650 NA -0.76 -12.26 -0.56 8.47e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7647973 0.710 rs11130208 chr3:49615624 G/T cg03060546 chr3:49711283 APEH 0.64 6.96 0.36 1.76e-11 Menarche (age at onset); LUSC cis rs7659604 0.540 rs10007956 chr4:122700669 A/T cg20573242 chr4:122745356 CCNA2 -0.44 -6.76 -0.35 6.05e-11 Type 2 diabetes; LUSC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.59 9.05 0.44 1.16e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs68170813 0.559 rs76933738 chr7:106814574 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.68 -0.47 1.04e-19 Coronary artery disease; LUSC cis rs10751667 1.000 rs10902246 chr11:953674 T/C ch.11.42038R chr11:967971 AP2A2 0.54 8.24 0.41 4.01e-15 Alzheimer's disease (late onset); LUSC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.42 0.5 3.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg16624210 chr5:671434 TPPP 0.5 6.38 0.33 6.07e-10 Obesity-related traits; LUSC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg15485101 chr11:133734466 NA 0.4 7.15 0.36 5.64e-12 Childhood ear infection; LUSC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg17279839 chr7:150038598 RARRES2 0.54 8.1 0.41 1.06e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs7973719 1.000 rs12828421 chr12:7335217 C/T cg07052231 chr12:7363540 PEX5 -0.52 -9.14 -0.45 6.28e-18 IgG glycosylation; LUSC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg05084668 chr3:125655381 ALG1L -0.49 -6.86 -0.35 3.26e-11 Blood pressure (smoking interaction); LUSC cis rs55665837 1.000 rs12283797 chr11:14442262 C/G cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC trans rs7193541 0.550 rs28607667 chr16:74476015 C/T cg03033975 chr20:60776546 GTPBP5 0.33 6.11 0.32 2.85e-9 Multiple myeloma; LUSC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.66 8.12 0.41 9.32e-15 Lung function (FEV1/FVC); LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg25767906 chr1:53392781 SCP2 -0.49 -8.92 -0.44 3.09e-17 Monocyte count; LUSC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg07701084 chr6:150067640 NUP43 0.51 7.56 0.38 3.97e-13 Lung cancer; LUSC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.84e-11 Aortic root size; LUSC cis rs1957429 0.731 rs28370916 chr14:65346094 A/G cg23373153 chr14:65346875 NA 1.09 12.7 0.57 2.03e-30 Pediatric areal bone mineral density (radius); LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.79 0.6 1.47e-34 Alzheimer's disease; LUSC cis rs9790314 1.000 rs336570 chr3:161072054 A/G cg03342759 chr3:160939853 NMD3 0.53 9.01 0.44 1.67e-17 Morning vs. evening chronotype; LUSC cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs6063312 0.667 rs9679994 chr20:47281853 T/C cg18078177 chr20:47281410 PREX1 0.72 11.16 0.52 8.41e-25 Tonometry; LUSC cis rs34779708 0.897 rs34481177 chr10:35380913 C/T cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8028313 0.731 rs7172055 chr15:67938334 G/C cg05925327 chr15:68127851 NA -0.38 -6.01 -0.31 4.85e-9 Obesity; LUSC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg22875332 chr1:76189707 ACADM 0.84 13.7 0.6 3.38e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg01689657 chr7:91764605 CYP51A1 -0.34 -6.26 -0.32 1.19e-9 Breast cancer; LUSC cis rs1440410 0.835 rs11722027 chr4:144050017 G/A cg01719995 chr4:144104893 USP38 0.32 5.74 0.3 2.09e-8 Ischemic stroke; LUSC cis rs7094131 0.549 rs10219113 chr10:22875788 T/C cg19500236 chr10:22911537 PIP4K2A 0.36 6.13 0.32 2.53e-9 Obesity-related traits; LUSC cis rs9527 0.615 rs10883800 chr10:104671212 A/C cg05855489 chr10:104503620 C10orf26 0.52 8.02 0.4 1.85e-14 Arsenic metabolism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06523340 chr1:231376895 GNPAT;C1orf131 -0.42 -6.25 -0.32 1.23e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9303401 0.614 rs35057477 chr17:57097064 G/A cg25039879 chr17:56429692 SUPT4H1 0.69 9.04 0.44 1.26e-17 Cognitive test performance; LUSC cis rs7223966 1.000 rs8075257 chr17:61728750 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 6.36 0.33 6.48e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1267303 0.798 rs1267302 chr1:46990545 G/C cg25110126 chr1:46999211 NA -0.66 -9.14 -0.45 6.25e-18 Monobrow; LUSC cis rs10504229 0.680 rs16921675 chr8:58052082 A/G cg08219700 chr8:58056026 NA 0.44 5.82 0.3 1.35e-8 Developmental language disorder (linguistic errors); LUSC cis rs250677 0.522 rs11954893 chr5:148392362 A/G cg18129178 chr5:148520854 ABLIM3 -0.54 -7.87 -0.4 5.01e-14 Breast cancer; LUSC cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC trans rs9567307 1 rs9567307 chr13:44471877 A/G cg12856521 chr11:46389249 DGKZ 0.57 7.47 0.38 7.2e-13 Leprosy; LUSC trans rs7726839 0.540 rs57306627 chr5:597643 T/C cg11887960 chr12:57824829 NA 0.54 6.74 0.35 7.11e-11 Obesity-related traits; LUSC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg04248312 chr19:17393744 ANKLE1 -1.0 -16.54 -0.67 2.57e-45 Systemic lupus erythematosus; LUSC cis rs9467773 1.000 rs9461271 chr6:26554968 G/A cg11502198 chr6:26597334 ABT1 0.62 9.85 0.47 2.95e-20 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg05340658 chr4:99064831 C4orf37 0.63 10.01 0.48 8.32e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg18758796 chr5:131593413 PDLIM4 0.4 6.61 0.34 1.49e-10 Blood metabolite levels; LUSC cis rs6424115 0.546 rs35993651 chr1:24180613 C/G cg10978503 chr1:24200527 CNR2 -0.52 -12.47 -0.56 1.48e-29 Immature fraction of reticulocytes; LUSC cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg21535247 chr6:8435926 SLC35B3 -0.58 -8.99 -0.44 1.9e-17 Motion sickness; LUSC cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.83 -0.47 3.42e-20 Chronic sinus infection; LUSC cis rs6596100 0.538 rs59682592 chr5:132196800 C/T cg02081065 chr5:132209139 LEAP2 -0.62 -5.9 -0.31 9.1e-9 Breast cancer; LUSC cis rs12519773 0.526 rs4869415 chr5:92522764 A/G cg18783429 chr5:92414398 NA 0.33 7.3 0.37 2.17e-12 Migraine; LUSC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg03433033 chr1:76189801 ACADM 0.8 13.31 0.59 9.95e-33 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9611519 0.828 rs28814423 chr22:41452301 G/A cg03806693 chr22:41940476 POLR3H -0.54 -7.39 -0.38 1.15e-12 Neuroticism; LUSC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.19 -0.37 4.24e-12 Alzheimer's disease (late onset); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg09363194 chr3:197282902 BDH1 0.37 5.95 0.31 6.64e-9 Metabolite levels (Pyroglutamine); LUSC cis rs11229555 0.645 rs11229549 chr11:58395914 T/C cg15696309 chr11:58395628 NA -0.69 -7.29 -0.37 2.21e-12 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg00166722 chr3:10149974 C3orf24 0.6 8.29 0.41 2.75e-15 Alzheimer's disease; LUSC cis rs12908161 1.000 rs35524990 chr15:85258203 T/C cg17507749 chr15:85114479 UBE2QP1 0.56 6.91 0.35 2.45e-11 Schizophrenia; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.9 0.4 4.17e-14 Prudent dietary pattern; LUSC cis rs7599312 0.534 rs7355673 chr2:213404389 T/C cg16329650 chr2:213403929 ERBB4 0.86 18.45 0.71 6.91e-53 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1668873 0.562 rs10157145 chr1:205261963 T/C cg21545522 chr1:205238299 TMCC2 -0.34 -6.45 -0.33 3.95e-10 Mean platelet volume; LUSC cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg14584255 chr6:163149320 PACRG;PARK2 -0.33 -6.3 -0.33 9.63e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9951602 0.541 rs12454297 chr18:76654445 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.05 0.58 9.85e-32 Obesity-related traits; LUSC trans rs8002861 0.967 rs7984393 chr13:44484361 T/C cg17145862 chr1:211918768 LPGAT1 0.23 6.1 0.32 2.97e-9 Leprosy; LUSC cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.51 7.14 0.36 5.94e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9479482 1.000 rs5017316 chr6:150333489 A/T cg25797454 chr6:150327115 RAET1K 0.35 8.26 0.41 3.36e-15 Alopecia areata; LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 16.04 0.66 2.51e-43 Platelet count; LUSC cis rs9858542 0.537 rs9863142 chr3:49366741 C/G cg03060546 chr3:49711283 APEH -0.55 -6.68 -0.34 9.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC trans rs453301 0.682 rs2929451 chr8:9085295 A/T cg27411982 chr8:10470053 RP1L1 0.43 7.08 0.36 8.55e-12 Joint mobility (Beighton score); LUSC cis rs1395 0.634 rs72817542 chr2:27526681 C/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.45 6.38 0.33 5.9e-10 Blood metabolite levels; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg15112475 chr7:1198522 ZFAND2A -0.28 -5.72 -0.3 2.31e-8 Longevity;Endometriosis; LUSC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1044826 0.619 rs7375091 chr3:139090389 T/A cg15131784 chr3:139108705 COPB2 -0.43 -7.09 -0.36 8.16e-12 Obesity-related traits; LUSC cis rs7119 0.717 rs8032071 chr15:77745762 C/T cg05673287 chr15:77411982 SGK269 0.45 6.96 0.36 1.85e-11 Type 2 diabetes; LUSC cis rs9902453 0.933 rs2054846 chr17:28507693 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.54 -8.33 -0.41 2.18e-15 Coffee consumption (cups per day); LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg25036284 chr2:26402008 FAM59B -0.72 -10.05 -0.48 6.06e-21 Gut microbiome composition (summer); LUSC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg00484396 chr16:3507460 NAT15 0.87 11.57 0.54 2.8e-26 Tuberculosis; LUSC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg11764359 chr7:65958608 NA -0.59 -9.26 -0.45 2.48e-18 Aortic root size; LUSC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg12656391 chr1:43425156 SLC2A1 -0.46 -7.26 -0.37 2.65e-12 Monocyte count; LUSC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg08680598 chr22:49984980 NA -0.33 -6.04 -0.31 4.16e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg09877947 chr5:131593287 PDLIM4 0.49 8.1 0.41 1.06e-14 Breast cancer; LUSC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg17252645 chr8:143867129 LY6D -0.45 -8.04 -0.4 1.56e-14 Urinary tract infection frequency; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10516465 chr14:102695515 RAGE 0.55 7.79 0.39 8.57e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg13256891 chr4:100009986 ADH5 0.46 6.39 0.33 5.71e-10 Alcohol dependence; LUSC cis rs9479482 1.000 rs9478380 chr6:150354665 A/G cg25797454 chr6:150327115 RAET1K -0.32 -7.09 -0.36 7.79e-12 Alopecia areata; LUSC cis rs4843747 0.671 rs4075599 chr16:88107423 C/G cg17633681 chr16:88106987 BANP 0.53 10.1 0.48 4.24e-21 Menopause (age at onset); LUSC trans rs7094131 0.542 rs7071306 chr10:22867339 A/G cg15415259 chr6:134158982 MGC34034 0.37 6.31 0.33 9.09e-10 Obesity-related traits; LUSC cis rs4776059 1.000 rs12915981 chr15:52901433 C/T cg22715398 chr15:52968154 KIAA1370 -0.69 -10.3 -0.49 8.61e-22 Schizophrenia; LUSC cis rs9314323 0.693 rs13264882 chr8:26224240 G/T cg13160058 chr8:26243215 BNIP3L -0.41 -7.2 -0.37 4.12e-12 Red cell distribution width; LUSC trans rs8072100 0.790 rs11079783 chr17:45686016 C/T cg03886242 chr7:26192032 NFE2L3 0.41 6.53 0.34 2.43e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs3126085 0.935 rs4845751 chr1:152208997 T/C cg26876637 chr1:152193138 HRNR 0.45 6.29 0.33 9.81e-10 Atopic dermatitis; LUSC cis rs4865169 0.595 rs4865165 chr4:57765546 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.38 -5.83 -0.3 1.33e-8 Breast cancer; LUSC trans rs911555 0.692 rs7146215 chr14:103915908 A/G cg17675199 chr6:35436792 RPL10A -0.4 -5.95 -0.31 6.75e-9 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.620 rs6925087 chr6:26592853 T/A cg05738196 chr6:26577821 NA 0.8 15.3 0.64 2.07e-40 Intelligence (multi-trait analysis); LUSC cis rs909002 0.800 rs1061770 chr1:32096265 A/G cg01639898 chr1:32083012 HCRTR1 0.31 7.36 0.37 1.48e-12 Intelligence (multi-trait analysis); LUSC cis rs2637266 0.703 rs2583062 chr10:78558472 T/C cg18941641 chr10:78392320 NA 0.37 6.7 0.34 8.79e-11 Pulmonary function; LUSC cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg14552801 chr7:65878734 NA -0.37 -5.77 -0.3 1.8e-8 Aortic root size; LUSC cis rs4363385 0.791 rs489323 chr1:153006047 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs7085104 0.513 rs619824 chr10:104581288 G/T cg15744005 chr10:104629667 AS3MT -0.31 -6.55 -0.34 2.16e-10 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2853333 0.622 rs2853332 chr19:35746706 A/G cg12287945 chr19:35758300 LSR -0.39 -5.7 -0.3 2.71e-8 Red blood cell count; LUSC cis rs11971779 0.680 rs10242419 chr7:139089380 A/G cg23387468 chr7:139079360 LUC7L2 -0.42 -6.39 -0.33 5.71e-10 Diisocyanate-induced asthma; LUSC trans rs1814175 0.645 rs28627251 chr11:50048125 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg12165864 chr7:66369176 NA -0.48 -6.5 -0.33 2.97e-10 Corneal structure; LUSC cis rs908922 0.651 rs564107 chr1:152519295 C/T cg20991723 chr1:152506922 NA 0.5 9.28 0.45 2.18e-18 Hair morphology; LUSC trans rs7613875 0.620 rs17657664 chr3:50032008 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.49 7.64 0.39 2.28e-13 Body mass index; LUSC cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs2806561 0.765 rs1738468 chr1:23510850 T/G cg19743168 chr1:23544995 NA 0.4 7.93 0.4 3.22e-14 Height; LUSC cis rs1030877 0.515 rs2679895 chr2:105906480 C/G cg02079111 chr2:105885981 TGFBRAP1 0.65 9.12 0.45 7.11e-18 Obesity-related traits; LUSC trans rs1325195 0.840 rs2816178 chr1:179249538 G/C cg11624085 chr17:8464688 MYH10 0.45 7.37 0.37 1.34e-12 IgE grass sensitization; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg03562264 chr6:36646551 CDKN1A -0.38 -6.37 -0.33 6.42e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg03676636 chr4:99064102 C4orf37 0.32 7.05 0.36 1.06e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg08847533 chr14:75593920 NEK9 -0.76 -12.7 -0.57 2.1000000000000002e-30 Height; LUSC cis rs8014204 0.657 rs2884668 chr14:75281576 T/A cg06637938 chr14:75390232 RPS6KL1 0.51 8.09 0.4 1.12e-14 Caffeine consumption; LUSC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC cis rs1144713 0.531 rs2683491 chr12:32250865 A/T cg01321189 chr12:32259338 BICD1 0.51 6.9 0.35 2.69e-11 Obesity-related traits; LUSC cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg23029597 chr12:123009494 RSRC2 -0.73 -9.77 -0.47 5.58e-20 Body mass index; LUSC cis rs9837602 1.000 rs62285478 chr3:99822135 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.43 -6.13 -0.32 2.47e-9 Breast cancer; LUSC cis rs2108225 0.900 rs4518594 chr7:107451060 G/C cg18560240 chr7:107437656 SLC26A3 -0.43 -6.48 -0.33 3.34e-10 Ulcerative colitis; LUSC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg03060546 chr3:49711283 APEH 0.66 7.33 0.37 1.74e-12 Menarche (age at onset); LUSC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg03517284 chr6:25882590 NA -0.46 -7.88 -0.4 4.57e-14 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.22e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1595825 0.786 rs16826740 chr2:198893927 A/G cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs921968 0.541 rs4674314 chr2:219423520 A/G cg02176678 chr2:219576539 TTLL4 -0.7 -13.07 -0.58 8.09e-32 Mean corpuscular hemoglobin concentration; LUSC cis rs12760731 0.623 rs12691480 chr1:178328790 T/A cg00404053 chr1:178313656 RASAL2 0.47 5.75 0.3 2.03e-8 Obesity-related traits; LUSC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg06238570 chr21:40685208 BRWD1 -0.61 -10.25 -0.49 1.24e-21 Cognitive function; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.94 0.31 7.17e-9 Menopause (age at onset); LUSC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.15 -0.32 2.2e-9 Lung cancer; LUSC cis rs3790645 1.000 rs383913 chr1:26893306 A/G cg17456097 chr1:26900765 RPS6KA1 0.42 6.08 0.32 3.36e-9 Glucose homeostasis traits; LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg06108461 chr20:60628389 TAF4 -0.74 -12.2 -0.56 1.41e-28 Body mass index; LUSC cis rs12594515 1.000 rs8025258 chr15:45987554 C/A cg19682013 chr15:45996608 NA 0.4 6.02 0.31 4.62e-9 Waist circumference;Weight; LUSC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg02018176 chr4:1364513 KIAA1530 0.55 9.68 0.47 1.09e-19 Longevity; LUSC cis rs10927875 0.864 rs6674071 chr1:16144855 G/C cg22431228 chr1:16359049 CLCNKA 0.4 7.31 0.37 2.05e-12 Dilated cardiomyopathy; LUSC cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.68 -0.43 1.81e-16 Body mass index; LUSC cis rs1865760 0.602 rs2157050 chr6:26020431 C/T cg16482183 chr6:26056742 HIST1H1C 0.5 7.28 0.37 2.43e-12 Height; LUSC cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.05 -0.36 1.06e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs859767 0.501 rs10210052 chr2:135417350 C/T cg12500956 chr2:135428796 TMEM163 -0.28 -6.65 -0.34 1.17e-10 Neuroticism; LUSC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg08280861 chr8:58055591 NA 0.58 6.38 0.33 6.01e-10 Developmental language disorder (linguistic errors); LUSC trans rs4942242 0.663 rs9525817 chr13:44225189 C/T cg19169023 chr15:41853346 TYRO3 0.61 9.31 0.45 1.77e-18 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11018904 0.906 rs10501713 chr11:89953013 G/A cg26138821 chr11:89956704 CHORDC1 -0.58 -6.93 -0.35 2.24e-11 Intelligence (multi-trait analysis); LUSC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs3862030 0.533 rs715440 chr10:104258095 A/T cg05855489 chr10:104503620 C10orf26 0.5 7.48 0.38 6.66e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs1461503 0.966 rs11218908 chr11:122841687 A/G cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs9487051 1.000 rs13191948 chr6:109634599 C/T cg01475377 chr6:109611718 NA -0.44 -7.82 -0.39 6.88e-14 Reticulocyte fraction of red cells; LUSC trans rs747782 0.527 rs7129364 chr11:48150576 G/A cg15704280 chr7:45808275 SEPT13 0.72 6.48 0.33 3.37e-10 Intraocular pressure; LUSC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg06640241 chr16:89574553 SPG7 0.91 16.57 0.67 2.07e-45 Multiple myeloma (IgH translocation); LUSC cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.54 -0.42 4.67e-16 Systolic blood pressure; LUSC cis rs10100465 0.889 rs7815693 chr8:118684198 A/G cg09430518 chr8:118662568 NA 0.32 6.04 0.31 4.07e-9 Leprosy; LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg04317338 chr11:64019027 PLCB3 0.71 8.04 0.4 1.57e-14 Mean platelet volume; LUSC cis rs17818399 0.926 rs35682608 chr2:46836542 A/T cg26688816 chr2:46740690 ATP6V1E2 -0.43 -5.84 -0.3 1.21e-8 Height; LUSC cis rs360798 0.532 rs1022110 chr2:63046039 T/G cg17519650 chr2:63277830 OTX1 -0.47 -6.52 -0.34 2.6200000000000003e-10 Coronary artery disease; LUSC cis rs7100689 0.599 rs946892 chr10:82127551 C/T cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg04414720 chr1:150670196 GOLPH3L 0.53 8.11 0.41 9.43e-15 Melanoma; LUSC cis rs4812048 0.689 rs151360 chr20:57613373 T/C cg14073986 chr20:57617431 SLMO2 0.5 5.79 0.3 1.58e-8 Mean platelet volume; LUSC cis rs742320 0.756 rs3765263 chr16:840378 A/G cg03433313 chr16:819064 MIR662 -0.53 -8.74 -0.43 1.15e-16 Mean corpuscular volume; LUSC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg09796270 chr17:17721594 SREBF1 0.39 6.78 0.35 5.48e-11 Total body bone mineral density; LUSC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -7.93 -0.4 3.44e-14 Type 2 diabetes; LUSC cis rs11601602 0.576 rs4075635 chr11:28511643 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.46 6.18 0.32 1.91e-9 Obesity-related traits; LUSC cis rs6087990 0.965 rs2424904 chr20:31352316 T/C cg13636640 chr20:31349939 DNMT3B 1.04 23.39 0.79 2.56e-72 Ulcerative colitis; LUSC cis rs6542838 0.553 rs6739503 chr2:99537295 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.51 -7.06 -0.36 9.45e-12 Fear of minor pain; LUSC cis rs12200560 0.505 rs4240555 chr6:97076274 T/C cg06623918 chr6:96969491 KIAA0776 0.5 7.2 0.37 3.9e-12 Coronary heart disease; LUSC cis rs6714710 0.557 rs17490429 chr2:98449024 G/A cg26665480 chr2:98280029 ACTR1B 0.61 8.91 0.44 3.25e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs2625529 0.824 rs4131630 chr15:72355398 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.52 -0.38 5.01e-13 Red blood cell count; LUSC cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg08999081 chr20:33150536 PIGU 0.38 6.79 0.35 5.22e-11 Height; LUSC cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg26441486 chr22:50317300 CRELD2 0.52 7.95 0.4 2.85e-14 Schizophrenia; LUSC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg06640241 chr16:89574553 SPG7 0.89 16.03 0.66 2.6900000000000002e-43 Multiple myeloma (IgH translocation); LUSC cis rs59698941 0.943 rs4705978 chr5:132245433 C/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg13319975 chr6:146136371 FBXO30 -0.71 -11.4 -0.53 1.19e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.29 0.62 1.69e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg06784218 chr1:46089804 CCDC17 -0.54 -10.93 -0.51 5.7e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg09796270 chr17:17721594 SREBF1 -0.4 -6.95 -0.36 1.88e-11 Total body bone mineral density; LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg12560992 chr17:57184187 TRIM37 0.8 13.87 0.6 7.05e-35 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs1030877 0.521 rs2576747 chr2:105978676 A/T cg02079111 chr2:105885981 TGFBRAP1 0.54 9.08 0.44 9.97e-18 Obesity-related traits; LUSC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg06238570 chr21:40685208 BRWD1 -0.55 -8.67 -0.43 1.87e-16 Menarche (age at onset); LUSC cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg00071950 chr4:10020882 SLC2A9 0.57 9.63 0.47 1.62e-19 Bone mineral density; LUSC cis rs17270561 0.609 rs4712960 chr6:25727265 C/T cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC cis rs8060686 0.641 rs7199588 chr16:68224582 C/T cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs1371867 0.875 rs1125706 chr8:101326739 T/A cg00191853 chr8:101177733 SPAG1 -0.4 -6.42 -0.33 4.77e-10 Atrioventricular conduction; LUSC cis rs4363385 0.553 rs28924721 chr1:152974254 C/T cg00922841 chr1:152955080 SPRR1A -0.38 -6.48 -0.33 3.3e-10 Inflammatory skin disease; LUSC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg21854759 chr1:92012499 NA -0.51 -8.58 -0.43 3.57e-16 Breast cancer; LUSC cis rs790123 0.565 rs112785037 chr3:122386128 A/T cg00926285 chr3:122398533 PARP14 -0.46 -6.0 -0.31 5.11e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg25072359 chr17:41440525 NA 0.64 9.06 0.44 1.15e-17 Menopause (age at onset); LUSC trans rs9329221 0.736 rs11249999 chr8:10251265 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.33 -0.37 1.74e-12 Neuroticism; LUSC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.7 10.79 0.51 1.68e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11122272 0.705 rs1416914 chr1:231533196 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.67 -10.49 -0.5 1.95e-22 Hemoglobin concentration; LUSC cis rs225245 0.694 rs321616 chr17:33882720 C/T cg05299278 chr17:33885742 SLFN14 0.31 6.95 0.36 1.94e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9486719 0.948 rs2092095 chr6:96870864 T/G cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs28785552 0.589 rs11669056 chr19:53244443 G/A cg10871876 chr19:53194124 ZNF83 0.55 8.04 0.4 1.55e-14 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs2721195 0.549 rs2620666 chr8:145703413 T/C cg17328964 chr8:145687451 CYHR1 -0.65 -10.79 -0.51 1.79e-23 Age at first birth; LUSC cis rs7106204 0.688 rs4462347 chr11:24218865 G/A ch.11.24196551F chr11:24239977 NA 0.95 9.31 0.45 1.8e-18 Response to Homoharringtonine (cytotoxicity); LUSC cis rs76878669 0.561 rs7948058 chr11:66148111 T/A cg18002602 chr11:66138449 SLC29A2 -0.49 -8.59 -0.43 3.27e-16 Educational attainment (years of education); LUSC cis rs13315871 1.000 rs74834816 chr3:58321828 G/A cg20936604 chr3:58311152 NA -0.76 -7.25 -0.37 2.83e-12 Cholesterol, total; LUSC trans rs11039798 1.000 rs9667626 chr11:48485877 T/C cg03929089 chr4:120376271 NA 0.65 6.0 0.31 5.21e-9 Axial length; LUSC cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg24692254 chr21:30365293 RNF160 -0.84 -15.46 -0.65 4.82e-41 Dental caries; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26859586 chr10:104953231 NT5C2 -0.49 -6.12 -0.32 2.58e-9 Bipolar disorder and schizophrenia; LUSC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg04871131 chr7:94954202 PON1 0.38 6.09 0.32 3.04e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg13175981 chr1:150552382 MCL1 0.52 7.37 0.37 1.37e-12 Tonsillectomy; LUSC cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg00049323 chr5:472564 LOC25845 0.48 7.57 0.38 3.68e-13 Cystic fibrosis severity; LUSC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg05855489 chr10:104503620 C10orf26 0.57 9.18 0.45 4.79e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6964587 1.000 rs6946356 chr7:91727385 G/A cg01689657 chr7:91764605 CYP51A1 0.33 5.84 0.3 1.23e-8 Breast cancer; LUSC cis rs7799006 0.929 rs71525363 chr7:2268792 G/A cg12823233 chr7:2316876 SNX8 -0.36 -6.0 -0.31 5.1e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg01579765 chr21:45077557 HSF2BP -0.46 -9.62 -0.47 1.67e-19 Mean corpuscular volume; LUSC cis rs2404602 0.669 rs12595313 chr15:76978370 A/G cg26408565 chr15:76604113 ETFA -0.49 -7.72 -0.39 1.38e-13 Blood metabolite levels; LUSC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs9929218 0.817 rs3118228 chr16:68710737 T/G cg02972257 chr16:68554789 NA 0.44 5.77 0.3 1.85e-8 Colorectal cancer; LUSC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg26513180 chr16:89883248 FANCA -0.53 -7.93 -0.4 3.42e-14 Vitiligo; LUSC trans rs11989744 0.597 rs2033788 chr8:23574847 G/T cg03492747 chr16:86543808 FOXF1 -0.61 -10.84 -0.51 1.16e-23 Waist-hip ratio; LUSC cis rs1461503 0.932 rs10790544 chr11:122838330 T/C cg27398637 chr11:122830231 C11orf63 -0.42 -6.68 -0.34 9.97e-11 Menarche (age at onset); LUSC cis rs2274273 0.901 rs10140801 chr14:55730404 C/T cg04306507 chr14:55594613 LGALS3 0.54 12.34 0.56 4.24e-29 Protein biomarker; LUSC cis rs4969178 0.930 rs2292644 chr17:76394449 C/T cg20026190 chr17:76395443 PGS1 0.45 8.17 0.41 6.52e-15 HDL cholesterol levels; LUSC cis rs3820928 0.775 rs10179756 chr2:227897076 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.73 -0.39 1.25e-13 Pulmonary function; LUSC cis rs9300255 0.510 rs1790133 chr12:123698518 T/G cg05973401 chr12:123451056 ABCB9 0.52 6.56 0.34 2e-10 Neutrophil percentage of white cells; LUSC trans rs724744 0.772 rs714590 chr6:22360029 A/G cg13807341 chr11:118445984 ARCN1 -0.35 -5.97 -0.31 6.14e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7605827 0.897 rs6753675 chr2:15539706 C/T cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg09849774 chr21:43526787 UMODL1;C21orf128 -0.55 -8.28 -0.41 3.08e-15 IgG glycosylation; LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.42 0.42 1.16e-15 Prudent dietary pattern; LUSC cis rs6542838 0.702 rs6739176 chr2:99536846 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.17 -0.32 1.93e-9 Fear of minor pain; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18030774 chr17:26733294 SLC46A1 -0.42 -6.08 -0.32 3.29e-9 Hepatitis; LUSC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg15145296 chr3:125709740 NA -0.58 -6.53 -0.34 2.4e-10 Blood pressure (smoking interaction); LUSC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg16145915 chr7:1198662 ZFAND2A -0.42 -6.01 -0.31 4.86e-9 Bronchopulmonary dysplasia; LUSC cis rs9322817 0.691 rs4504502 chr6:105325332 A/G cg02098413 chr6:105308735 HACE1 0.27 5.8 0.3 1.52e-8 Thyroid stimulating hormone; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg08888203 chr3:10149979 C3orf24 0.64 8.54 0.42 4.67e-16 Alzheimer's disease; LUSC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg01652190 chr22:50026171 C22orf34 -0.3 -6.32 -0.33 8.5e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg18876405 chr7:65276391 NA 0.76 13.23 0.59 1.95e-32 Aortic root size; LUSC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg16743903 chr16:89593216 SPG7 -0.39 -6.05 -0.31 3.86e-9 Multiple myeloma (IgH translocation); LUSC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg24838063 chr12:130822603 PIWIL1 0.71 11.02 0.52 2.72e-24 Menopause (age at onset); LUSC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs13040088 1.000 rs2295000 chr20:61536938 A/G cg23096297 chr20:61557774 DIDO1 -0.86 -11.63 -0.54 1.82e-26 Menopause (age at onset); LUSC cis rs7599312 0.534 rs7607363 chr2:213402705 A/G cg20637307 chr2:213403960 ERBB4 0.44 7.51 0.38 5.38e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7089973 0.836 rs7895551 chr10:116625481 C/T cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 5.96e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.83 0.39 6.4e-14 Lymphocyte counts; LUSC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg16928487 chr17:17741425 SREBF1 -0.45 -9.11 -0.45 7.85e-18 Total body bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03800012 chr7:35734842 HERPUD2 0.67 6.01 0.31 4.81e-9 Cognitive performance; LUSC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.07e-11 Blood metabolite levels; LUSC cis rs231513 0.911 rs231476 chr17:41985845 A/G cg26893861 chr17:41843967 DUSP3 -0.57 -6.44 -0.33 4.17e-10 Cognitive function; LUSC cis rs4073416 0.568 rs7145759 chr14:65884537 C/A cg03016385 chr14:66212404 NA -0.4 -5.93 -0.31 7.76e-9 N-glycan levels; LUSC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg25019033 chr10:957182 NA -0.52 -6.99 -0.36 1.53e-11 Eosinophil percentage of granulocytes; LUSC cis rs4706831 0.647 rs9350847 chr6:80889017 C/T cg08355045 chr6:80787529 NA 0.46 8.01 0.4 1.96e-14 Joint mobility (Beighton score); LUSC trans rs57221529 0.766 rs12522140 chr5:587261 C/A cg25482853 chr8:67687455 SGK3 1.18 16.97 0.68 5.1e-47 Lung disease severity in cystic fibrosis; LUSC cis rs151234 0.741 rs11644791 chr16:28601186 G/C cg01378222 chr16:28622494 SULT1A1 -0.64 -8.55 -0.42 4.58e-16 Platelet distribution width; LUSC cis rs2625529 0.689 rs4526973 chr15:72138719 A/G cg16672083 chr15:72433130 SENP8 -0.48 -8.01 -0.4 1.98e-14 Red blood cell count; LUSC cis rs2976388 1.000 rs2976396 chr8:143764001 A/G cg17252645 chr8:143867129 LY6D 0.35 6.08 0.32 3.32e-9 Urinary tract infection frequency; LUSC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg25072359 chr17:41440525 NA 0.66 9.25 0.45 2.81e-18 Menopause (age at onset); LUSC cis rs17685 0.753 rs2302438 chr7:75677065 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.54 -8.41 -0.42 1.24e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7264396 1.000 rs224418 chr20:34142527 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.75 -0.35 6.68e-11 Total cholesterol levels; LUSC cis rs6942756 1.000 rs12112374 chr7:128950071 A/G cg02491457 chr7:128862824 NA -0.48 -6.63 -0.34 1.32e-10 White matter hyperintensity burden; LUSC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg04414720 chr1:150670196 GOLPH3L -0.49 -7.99 -0.4 2.23e-14 Tonsillectomy; LUSC cis rs950027 0.620 rs2486274 chr15:45666228 G/T cg14582100 chr15:45693742 SPATA5L1 0.46 8.67 0.43 1.87e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.88 -11.44 -0.53 8.54e-26 Chronic sinus infection; LUSC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg24881330 chr22:46731750 TRMU 0.82 7.29 0.37 2.32e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.63 0.86 5.12e-99 Chronic sinus infection; LUSC cis rs295140 0.605 rs296818 chr2:201176944 C/T cg04283868 chr2:201171347 SPATS2L -0.42 -6.17 -0.32 1.99e-9 QT interval; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg21782813 chr7:2030301 MAD1L1 0.49 8.35 0.42 1.86e-15 Bipolar disorder and schizophrenia; LUSC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg25072359 chr17:41440525 NA 0.62 9.02 0.44 1.53e-17 Menopause (age at onset); LUSC cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.29 0.37 2.31e-12 Motion sickness; LUSC cis rs6598955 1.000 rs10902728 chr1:26598281 T/C cg04990556 chr1:26633338 UBXN11 0.84 13.73 0.6 2.55e-34 Obesity-related traits; LUSC trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg20587970 chr11:113659929 NA -1.32 -18.42 -0.71 8.8e-53 Hip circumference adjusted for BMI; LUSC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg18230493 chr5:56204884 C5orf35 -0.92 -13.72 -0.6 2.86e-34 Initial pursuit acceleration; LUSC cis rs826838 0.935 rs3886109 chr12:39189243 C/T cg26384229 chr12:38710491 ALG10B 0.89 16.7 0.67 5.82e-46 Heart rate; LUSC cis rs698813 0.763 rs698764 chr2:44573658 T/C cg00619915 chr2:44497795 NA -0.39 -5.72 -0.3 2.4e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.48 0.33 3.28e-10 Lung cancer; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.84 -16.25 -0.66 3.64e-44 Prudent dietary pattern; LUSC cis rs1403694 0.695 rs1050274 chr3:186435370 G/A cg12454167 chr3:186435060 KNG1 0.34 8.47 0.42 8.11e-16 Blood protein levels; LUSC cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg06462663 chr19:18546047 ISYNA1 0.47 7.74 0.39 1.18e-13 Breast cancer; LUSC cis rs2370759 0.945 rs74625866 chr10:32597618 A/T cg01819863 chr10:32635814 EPC1 1.07 13.24 0.59 1.89e-32 Sexual dysfunction (female); LUSC cis rs259282 0.538 rs6510270 chr19:33114514 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.74 10.75 0.51 2.43e-23 Schizophrenia; LUSC cis rs2067615 0.579 rs7964605 chr12:107205413 C/T cg15890332 chr12:107067104 RFX4 -0.33 -5.9 -0.31 8.76e-9 Heart rate; LUSC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg24549020 chr5:56110836 MAP3K1 0.5 5.9 0.31 9.09e-9 Initial pursuit acceleration; LUSC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg23158103 chr7:148848205 ZNF398 0.45 7.37 0.37 1.31e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg10172584 chr19:19639581 YJEFN3 -0.49 -5.76 -0.3 1.92e-8 Bipolar disorder; LUSC cis rs7824557 0.606 rs1435277 chr8:11196970 C/T cg21775007 chr8:11205619 TDH 0.78 12.63 0.57 3.63e-30 Retinal vascular caliber; LUSC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.75 -9.96 -0.48 1.22e-20 Schizophrenia; LUSC cis rs3737883 1.000 rs4590732 chr1:203028711 C/G cg00805880 chr1:203045044 PPFIA4 -0.31 -6.2 -0.32 1.66e-9 Early onset atrial fibrillation; LUSC cis rs7705502 1.000 rs72812850 chr5:173378286 T/G cg18693985 chr5:173351052 CPEB4 -0.39 -6.02 -0.31 4.5e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18404041 chr3:52824283 ITIH1 -0.48 -8.94 -0.44 2.67e-17 Cognitive function; LUSC cis rs6815814 0.950 rs5743563 chr4:38806019 A/G cg02016764 chr4:38805732 TLR1 -0.53 -5.74 -0.3 2.16e-8 Breast cancer; LUSC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.55 7.45 0.38 8.11e-13 Lung function (FEV1/FVC); LUSC cis rs7568458 0.846 rs6547621 chr2:85774676 G/A cg23752985 chr2:85803571 VAMP8 0.34 7.14 0.36 5.9e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg23188684 chr11:67383651 NA 0.34 6.01 0.31 4.91e-9 Mean corpuscular volume; LUSC cis rs7824557 0.767 rs6991606 chr8:11176159 G/A cg27411982 chr8:10470053 RP1L1 0.4 6.36 0.33 6.46e-10 Retinal vascular caliber; LUSC cis rs4566357 0.615 rs2396445 chr2:227917726 C/G cg11843606 chr2:227700838 RHBDD1 -0.54 -8.19 -0.41 5.78e-15 Coronary artery disease; LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg02475777 chr4:1388615 CRIPAK -0.58 -8.58 -0.43 3.56e-16 Obesity-related traits; LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg11843238 chr5:131593191 PDLIM4 0.46 7.94 0.4 3.15e-14 Acylcarnitine levels; LUSC cis rs137603 0.602 rs137654 chr22:39732413 C/T cg17798944 chr22:39715225 SNORD43;RPL3 -0.5 -7.91 -0.4 3.7e-14 Primary biliary cholangitis; LUSC cis rs11252926 0.545 rs1551508 chr10:555469 A/G cg18196295 chr10:418757 DIP2C 0.38 6.05 0.31 3.84e-9 Psychosis in Alzheimer's disease; LUSC trans rs7726839 0.574 rs12522955 chr5:639231 C/A cg11887960 chr12:57824829 NA 0.53 6.56 0.34 2.03e-10 Obesity-related traits; LUSC cis rs2302777 0.507 rs9889711 chr17:38108292 A/T cg17467752 chr17:38218738 THRA 0.41 5.69 0.3 2.73e-8 Multiple myeloma (hyperdiploidy); LUSC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg02038168 chr22:39784481 NA -0.49 -8.2 -0.41 5.38e-15 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg06784218 chr1:46089804 CCDC17 0.54 10.88 0.51 8.41e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs804280 1.000 rs804280 chr8:11612698 G/T cg08975724 chr8:8085496 FLJ10661 0.44 6.39 0.33 5.57e-10 Myopia (pathological); LUSC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg18404041 chr3:52824283 ITIH1 -0.54 -8.48 -0.42 7.41e-16 Bipolar disorder; LUSC cis rs62400317 0.826 rs12203466 chr6:45330263 T/A cg20913747 chr6:44695427 NA -0.48 -7.8 -0.39 7.82e-14 Total body bone mineral density; LUSC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg09436375 chr6:42928200 GNMT -0.29 -6.58 -0.34 1.83e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2486288 0.539 rs2433601 chr15:45716425 T/C cg26924012 chr15:45694286 SPATA5L1 0.77 11.93 0.55 1.43e-27 Glomerular filtration rate; LUSC cis rs10979 1.000 rs3748072 chr6:143889757 C/T cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs10791323 0.569 rs10750552 chr11:133740141 A/C cg15485101 chr11:133734466 NA -0.37 -7.06 -0.36 9.75e-12 Childhood ear infection; LUSC cis rs7605827 0.930 rs11681044 chr2:15717058 G/A cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.47e-16 Educational attainment (years of education); LUSC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg03948781 chr1:205179583 DSTYK 0.3 5.74 0.3 2.08e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.15 -0.49 2.8e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg04414720 chr1:150670196 GOLPH3L -0.51 -8.06 -0.4 1.37e-14 Melanoma; LUSC cis rs4789693 0.679 rs7217570 chr17:80379332 G/T cg04308225 chr17:80449738 NA -0.41 -6.35 -0.33 6.92e-10 Glucocorticoid-induced osteonecrosis; LUSC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.78 -13.72 -0.6 2.75e-34 Total body bone mineral density; LUSC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg03526776 chr6:41159608 TREML2 0.34 6.53 0.34 2.51e-10 Alzheimer's disease (late onset); LUSC cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs4363385 0.818 rs2711 chr1:153005156 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.37 0.64 1.09e-40 Platelet count; LUSC cis rs1775715 0.835 rs113450267 chr10:32223728 G/A cg26784012 chr10:32216390 ARHGAP12 0.41 6.76 0.35 6.06e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg12292205 chr6:26970375 C6orf41 -0.56 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.12 0.32 2.59e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs800082 1.000 rs1007564 chr3:144311843 C/T cg24215973 chr2:240111563 HDAC4 -0.47 -7.24 -0.37 3.08e-12 Smoking behavior; LUSC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg04369109 chr6:150039330 LATS1 -0.59 -8.76 -0.43 1.02e-16 Lung cancer; LUSC cis rs12421382 0.659 rs1439511 chr11:109392839 G/T cg16359550 chr11:109292809 C11orf87 -0.41 -6.42 -0.33 4.67e-10 Schizophrenia; LUSC cis rs62400317 0.762 rs12198308 chr6:44911886 C/T cg20913747 chr6:44695427 NA -0.48 -7.4 -0.38 1.09e-12 Total body bone mineral density; LUSC cis rs4595586 0.545 rs6580896 chr12:39372223 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs2742234 1.000 rs1864399 chr10:43610455 T/C cg02780029 chr10:43622663 RET -0.34 -6.22 -0.32 1.44e-9 Hirschsprung disease; LUSC cis rs453301 0.658 rs9329175 chr8:8866661 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.64 -0.43 2.35e-16 Joint mobility (Beighton score); LUSC cis rs7681440 0.869 rs894280 chr4:90760883 C/T cg01966878 chr4:90757139 SNCA -0.36 -6.26 -0.32 1.16e-9 Dementia with Lewy bodies; LUSC trans rs4332037 0.539 rs11762636 chr7:2061111 C/A cg10840412 chr1:235813424 GNG4 0.57 7.34 0.37 1.61e-12 Bipolar disorder; LUSC cis rs9399135 0.967 rs7773126 chr6:135318390 A/G cg24558204 chr6:135376177 HBS1L 0.58 8.83 0.44 5.98e-17 Red blood cell count; LUSC cis rs7267979 0.844 rs1555330 chr20:25232097 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.68 12.94 0.58 2.53e-31 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7681440 0.583 rs1551980 chr4:90774724 G/A cg06632027 chr4:90757378 SNCA -0.37 -5.75 -0.3 1.99e-8 Dementia with Lewy bodies; LUSC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg06713675 chr4:122721982 EXOSC9 -0.72 -12.59 -0.57 5.26e-30 Type 2 diabetes; LUSC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.84 -11.2 -0.52 6.05e-25 Schizophrenia; LUSC cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg22782873 chr19:19639568 YJEFN3 0.49 5.81 0.3 1.48e-8 Bipolar disorder; LUSC cis rs11583043 1.000 rs6682873 chr1:101470906 C/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.81 0.3 1.49e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs6582630 0.502 rs11610978 chr12:38356957 C/G cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.5e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs202629 1 rs202629 chr22:41849975 C/T cg06634786 chr22:41940651 POLR3H 0.48 5.96 0.31 6.59e-9 Cannabis dependence symptom count; LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg00814883 chr7:100076585 TSC22D4 -0.75 -10.28 -0.49 1.04e-21 Platelet count; LUSC cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg06784218 chr1:46089804 CCDC17 0.48 9.58 0.46 2.38e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs561341 1.000 rs561341 chr17:30316385 T/G cg27661571 chr11:113659931 NA -0.69 -7.91 -0.4 3.77e-14 Hip circumference adjusted for BMI; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03344030 chr19:48673649 LIG1 -0.49 -5.95 -0.31 6.79e-9 Bipolar disorder and schizophrenia; LUSC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg03929089 chr4:120376271 NA -0.98 -16.38 -0.67 1.14e-44 Coronary artery disease; LUSC cis rs34734847 0.766 rs3794214 chr12:121168245 C/T cg27246729 chr12:121163418 ACADS -0.42 -6.63 -0.34 1.38e-10 Mean corpuscular volume; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg18538332 chr22:24372958 LOC391322 -0.39 -7.19 -0.37 4.22e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg08975724 chr8:8085496 FLJ10661 -0.47 -6.93 -0.35 2.22e-11 Joint mobility (Beighton score); LUSC trans rs3733585 0.673 rs4697914 chr4:9952266 G/A cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.13e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.52 0.34 2.63e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24583770 chr6:163836718 QKI -0.46 -6.94 -0.36 2.03e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs367943 1.000 rs168365 chr5:112817984 G/A cg12552261 chr5:112820674 MCC -0.44 -6.99 -0.36 1.49e-11 Type 2 diabetes; LUSC cis rs7107174 1.000 rs10899485 chr11:78072383 C/T cg02023728 chr11:77925099 USP35 -0.42 -6.29 -0.33 1.01e-9 Testicular germ cell tumor; LUSC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -11.64 -0.54 1.6e-26 Systemic lupus erythematosus; LUSC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg00343986 chr7:65444356 GUSB -0.48 -7.29 -0.37 2.19e-12 Aortic root size; LUSC cis rs7607369 0.536 rs6436089 chr2:219668813 A/G cg02176678 chr2:219576539 TTLL4 -0.52 -9.15 -0.45 5.72e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg08468370 chr19:39903678 PLEKHG2 0.41 6.25 0.32 1.28e-9 Schizophrenia; LUSC cis rs1003719 0.788 rs11911508 chr21:38470504 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs7605827 0.930 rs2058868 chr2:15679609 A/T cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs6456156 0.586 rs12527827 chr6:167469271 C/T cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs11098499 0.954 rs4577559 chr4:120404043 T/G cg24375607 chr4:120327624 NA 0.79 11.91 0.55 1.72e-27 Corneal astigmatism; LUSC cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg04117972 chr1:227635322 NA 0.57 6.58 0.34 1.78e-10 Major depressive disorder; LUSC cis rs3809863 0.646 rs9899121 chr17:45395144 C/T cg08085267 chr17:45401833 C17orf57 -0.65 -9.71 -0.47 8.79e-20 Glaucoma (primary open-angle); LUSC cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg08807101 chr21:30365312 RNF160 -0.68 -10.94 -0.51 5.08e-24 Pancreatic cancer; LUSC cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg14689365 chr7:158441557 NCAPG2 -0.43 -6.03 -0.31 4.25e-9 Height; LUSC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg14196790 chr5:131705035 SLC22A5 0.48 8.18 0.41 6.2e-15 Blood metabolite levels; LUSC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 14.04 0.61 1.64e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs8060686 0.641 rs7192187 chr16:68132109 T/C cg27539214 chr16:67997921 SLC12A4 -0.55 -7.56 -0.38 3.86e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.26 0.59 1.6e-32 Monocyte percentage of white cells; LUSC cis rs7937682 0.921 rs1944119 chr11:111436387 A/G cg19812747 chr11:111475976 SIK2 0.53 7.37 0.37 1.34e-12 Primary sclerosing cholangitis; LUSC cis rs4889911 0.544 rs2587498 chr17:77830737 G/A cg00646381 chr17:77835854 NA 0.6 9.75 0.47 6.38e-20 Electroencephalogram traits; LUSC cis rs7712401 0.601 rs415534 chr5:122325301 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs2708977 0.965 rs13019986 chr2:97243058 C/T cg01950434 chr2:97203154 ARID5A 0.57 8.8 0.43 7.21e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg11645453 chr3:52864694 ITIH4 0.34 7.87 0.4 5.04e-14 Intelligence (multi-trait analysis); LUSC cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg18252515 chr7:66147081 NA -0.57 -7.91 -0.4 3.93e-14 Corneal structure; LUSC cis rs6121246 0.909 rs3203770 chr20:30382315 A/G cg13852791 chr20:30311386 BCL2L1 0.88 11.73 0.54 7.4e-27 Mean corpuscular hemoglobin; LUSC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg12310025 chr6:25882481 NA -0.47 -8.17 -0.41 6.38e-15 Intelligence (multi-trait analysis); LUSC cis rs11758351 1.000 rs111596617 chr6:26191678 A/T cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs6500602 0.893 rs8061742 chr16:4489436 T/C cg08645402 chr16:4508243 NA 0.52 8.5 0.42 6.45e-16 Schizophrenia; LUSC cis rs1712517 0.588 rs12220267 chr10:105075712 C/T cg04362960 chr10:104952993 NT5C2 -0.5 -6.66 -0.34 1.1e-10 Migraine; LUSC trans rs11992162 0.569 rs11786149 chr8:11800818 G/A cg27411982 chr8:10470053 RP1L1 -0.44 -6.57 -0.34 1.98e-10 Monocyte count; LUSC cis rs11098499 0.789 rs9991166 chr4:120237851 G/A cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg22496380 chr5:211416 CCDC127 0.67 8.06 0.4 1.34e-14 Breast cancer; LUSC cis rs2073300 1.000 rs6137959 chr20:23442640 T/C cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12541635 0.902 rs62525696 chr8:106968703 C/T cg10147462 chr8:107024639 NA 0.55 9.55 0.46 2.83e-19 Age of smoking initiation; LUSC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.19 -0.32 1.79e-9 Total body bone mineral density; LUSC cis rs7568458 0.905 rs6547620 chr2:85755928 C/T cg23752985 chr2:85803571 VAMP8 0.33 7.06 0.36 9.49e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg03233332 chr7:66118400 NA -0.4 -5.92 -0.31 8.15e-9 Aortic root size; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg23102388 chr7:1867652 MAD1L1 -0.31 -5.93 -0.31 7.76e-9 Bipolar disorder and schizophrenia; LUSC trans rs2262909 0.849 rs2666447 chr19:22132868 T/A cg17074339 chr11:11642133 GALNTL4 -0.41 -6.21 -0.32 1.54e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7089973 0.604 rs11196947 chr10:116601372 G/A cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg07952391 chr2:88470173 THNSL2 0.75 6.68 0.34 1.03e-10 Plasma clusterin levels; LUSC cis rs10892173 1.000 rs10892173 chr11:117672561 C/T cg21640587 chr11:117668038 DSCAML1 0.38 5.75 0.3 2.05e-8 Myopia; LUSC cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.26 0.37 2.75e-12 Colorectal cancer; LUSC cis rs7829975 0.846 rs11779061 chr8:8549432 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -8.28 -0.41 3.02e-15 Mood instability; LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg11062466 chr8:58055876 NA 0.72 8.93 0.44 2.94e-17 Developmental language disorder (linguistic errors); LUSC cis rs11105298 0.891 rs11105299 chr12:89877943 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.04e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4805272 0.512 rs17772319 chr19:29343064 T/A cg04546413 chr19:29218101 NA 0.59 7.26 0.37 2.72e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg25039879 chr17:56429692 SUPT4H1 0.69 9.08 0.44 9.99e-18 Cognitive test performance; LUSC cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.49 8.12 0.41 9.06e-15 IgG glycosylation; LUSC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg02018176 chr4:1364513 KIAA1530 0.5 8.54 0.42 4.76e-16 Obesity-related traits; LUSC trans rs1493916 0.905 rs7239283 chr18:31395397 G/A cg27147174 chr7:100797783 AP1S1 -0.64 -10.29 -0.49 9.09e-22 Life satisfaction; LUSC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21659725 chr3:3221576 CRBN -0.86 -18.08 -0.7 1.89e-51 Intelligence (multi-trait analysis); LUSC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg10295955 chr4:187884368 NA -1.07 -26.09 -0.82 1.35e-82 Lobe attachment (rater-scored or self-reported); LUSC cis rs7191700 0.836 rs12708722 chr16:11428905 T/A cg00044050 chr16:11439710 C16orf75 0.57 8.34 0.42 1.98e-15 Multiple sclerosis; LUSC trans rs61931739 0.534 rs11053021 chr12:34111157 C/T cg26384229 chr12:38710491 ALG10B 0.71 11.22 0.52 5.05e-25 Morning vs. evening chronotype; LUSC cis rs524023 0.957 rs538737 chr11:64355772 C/G cg19131476 chr11:64387923 NRXN2 0.36 9.45 0.46 5.91e-19 Urate levels in obese individuals; LUSC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg27398817 chr8:82754497 SNX16 -0.66 -8.42 -0.42 1.13e-15 Diastolic blood pressure; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01382936 chr19:44716836 ZNF227 -0.41 -6.17 -0.32 1.99e-9 Electrocardiographic conduction measures; LUSC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg08045932 chr20:61659980 NA 0.59 10.39 0.49 4.41e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.47e-8 Extrinsic epigenetic age acceleration; LUSC cis rs12142240 0.698 rs17361950 chr1:46864150 C/T cg14993813 chr1:46806288 NSUN4 -0.55 -7.41 -0.38 1.07e-12 Menopause (age at onset); LUSC cis rs11122272 0.735 rs910823 chr1:231498766 G/T cg06096015 chr1:231504339 EGLN1 0.57 9.98 0.48 1.08e-20 Hemoglobin concentration; LUSC cis rs7011049 1.000 rs11997774 chr8:53833370 T/A cg26025543 chr8:53854495 NA 0.51 6.28 0.32 1.05e-9 Systolic blood pressure; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg00431813 chr7:1051703 C7orf50 -0.45 -7.25 -0.37 2.92e-12 Longevity;Endometriosis; LUSC cis rs1691799 0.867 rs1168341 chr12:66759080 G/C cg16791601 chr12:66731901 HELB -0.71 -12.37 -0.56 3.47e-29 White blood cell count (basophil); LUSC cis rs9811920 0.770 rs4928237 chr3:99731330 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -7.0 -0.36 1.41e-11 Axial length; LUSC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg11766577 chr21:47581405 C21orf56 -0.48 -7.16 -0.36 5.32e-12 Testicular germ cell tumor; LUSC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg25282410 chr6:160211355 TCP1;MRPL18 1.1 16.88 0.68 1.19e-46 Age-related macular degeneration (geographic atrophy); LUSC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.26e-9 Life satisfaction; LUSC cis rs9650657 0.740 rs12676417 chr8:10668634 C/T cg27411982 chr8:10470053 RP1L1 0.36 5.88 0.31 1.01e-8 Neuroticism; LUSC cis rs8060686 0.668 rs12448991 chr16:68218894 T/A cg05110241 chr16:68378359 PRMT7 -0.56 -6.39 -0.33 5.45e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg05373962 chr22:49881684 NA -0.45 -11.03 -0.52 2.43e-24 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8060686 0.546 rs8047343 chr16:68143745 G/A cg27539214 chr16:67997921 SLC12A4 -0.39 -5.97 -0.31 5.99e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6840360 0.571 rs6811676 chr4:152562726 T/C cg22705602 chr4:152727874 NA -0.3 -6.11 -0.32 2.83e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs7617773 0.851 rs6775179 chr3:48313418 T/C cg11946769 chr3:48343235 NME6 0.88 14.28 0.62 1.99e-36 Coronary artery disease; LUSC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.11 -0.58 6e-32 Platelet count; LUSC cis rs9486719 1.000 rs2145535 chr6:97034715 G/A cg06623918 chr6:96969491 KIAA0776 -0.84 -10.4 -0.49 3.86e-22 Migraine;Coronary artery disease; LUSC cis rs61332075 0.518 rs72994950 chr2:239422993 T/C cg18131467 chr2:239335373 ASB1 -0.7 -6.22 -0.32 1.49e-9 Lung function (FEV1/FVC); LUSC cis rs4132509 1.000 rs10754807 chr1:243804158 G/A cg21452805 chr1:244014465 NA 0.52 6.11 0.32 2.81e-9 RR interval (heart rate); LUSC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg02034447 chr16:89574710 SPG7 0.41 6.05 0.31 3.84e-9 Multiple myeloma (IgH translocation); LUSC cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs4363385 0.510 rs7532166 chr1:153046851 C/G cg00922841 chr1:152955080 SPRR1A -0.36 -6.07 -0.32 3.4e-9 Inflammatory skin disease; LUSC cis rs2797160 1.000 rs2211419 chr6:125995533 C/T cg05901451 chr6:126070800 HEY2 0.58 8.67 0.43 1.84e-16 Endometrial cancer; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg10802521 chr3:52805072 NEK4 -0.55 -8.98 -0.44 2.02e-17 Bipolar disorder; LUSC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg06494592 chr3:125709126 NA -0.5 -5.75 -0.3 2.04e-8 Blood pressure (smoking interaction); LUSC cis rs909341 0.909 rs1758205 chr20:62355756 G/A cg09650180 chr20:62225654 GMEB2 -0.47 -6.11 -0.32 2.75e-9 Atopic dermatitis; LUSC cis rs7772486 0.875 rs2777477 chr6:146305491 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.69 0.43 1.64e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7605827 0.930 rs6728145 chr2:15573489 C/G cg19274914 chr2:15703543 NA 0.47 8.93 0.44 2.86e-17 Educational attainment (years of education); LUSC cis rs6696846 1.000 rs6696846 chr1:205041952 C/T cg00857998 chr1:205179979 DSTYK 0.63 9.74 0.47 7.01e-20 Red blood cell count; LUSC cis rs738321 0.723 rs9622726 chr22:38506688 A/G cg25457927 chr22:38595422 NA -0.33 -6.39 -0.33 5.43e-10 Breast cancer; LUSC cis rs11209185 0.509 rs9436791 chr1:68452857 A/C cg22082780 chr1:68452167 NA 0.48 8.79 0.43 8.09e-17 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg21724239 chr8:58056113 NA 0.85 8.56 0.42 4.27e-16 Developmental language disorder (linguistic errors); LUSC cis rs9549367 0.789 rs9549699 chr13:113878263 T/A cg00898013 chr13:113819073 PROZ -0.58 -8.4 -0.42 1.3e-15 Platelet distribution width; LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg25036284 chr2:26402008 FAM59B -0.75 -10.98 -0.52 3.59e-24 Gut microbiome composition (summer); LUSC cis rs6456156 0.774 rs2022001 chr6:167529509 C/T cg07741184 chr6:167504864 NA -0.36 -6.34 -0.33 7.42e-10 Primary biliary cholangitis; LUSC trans rs11722228 0.508 rs3796826 chr4:10092728 G/A cg26043149 chr18:55253948 FECH 1.0 15.01 0.63 2.71e-39 Gout;Urate levels;Serum uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09393705 chr13:73356207 PIBF1;DIS3 -0.41 -6.06 -0.31 3.61e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg20135002 chr11:47629003 NA -0.52 -8.1 -0.41 1.04e-14 Subjective well-being; LUSC cis rs701145 0.537 rs1713842 chr3:153786243 T/A cg17054900 chr3:154042577 DHX36 -0.64 -6.69 -0.34 9.46e-11 Coronary artery disease; LUSC cis rs7267979 1.000 rs2424712 chr20:25416942 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.8 0.73 3e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg05283184 chr6:79620031 NA -0.57 -12.04 -0.55 5.67e-28 Intelligence (multi-trait analysis); LUSC cis rs7264396 0.563 rs2425089 chr20:34304036 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.56 -0.42 4.24e-16 Total cholesterol levels; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 4.97e-14 Prudent dietary pattern; LUSC cis rs11039100 1.000 rs35863965 chr11:5824256 G/T cg05234568 chr11:5960015 NA -0.51 -5.72 -0.3 2.35e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11608355 0.515 rs11611011 chr12:109936948 C/T cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs16937 0.711 rs6675633 chr1:205100480 G/A cg00857998 chr1:205179979 DSTYK 0.46 6.56 0.34 1.99e-10 Schizophrenia; LUSC cis rs11610422 1.000 rs12824070 chr12:31414280 C/T cg14306366 chr12:31406441 NA -0.51 -6.27 -0.32 1.09e-9 Coronary artery disease; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg01577475 chr2:114033581 PAX8;LOC440839 -0.28 -7.01 -0.36 1.3e-11 Lymphocyte counts; LUSC cis rs72829446 0.530 rs4796421 chr17:7379650 C/T cg02795151 chr17:7402630 POLR2A 0.57 6.78 0.35 5.34e-11 Androgen levels; LUSC cis rs16854884 1.000 rs16854884 chr3:143778708 A/C cg06585982 chr3:143692056 C3orf58 0.47 6.61 0.34 1.56e-10 Economic and political preferences (feminism/equality); LUSC cis rs7267979 0.932 rs6107052 chr20:25530838 G/A cg08601574 chr20:25228251 PYGB 0.41 6.18 0.32 1.91e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7584330 0.737 rs60187585 chr2:238365159 C/T cg14458575 chr2:238380390 NA 0.68 12.06 0.55 4.8e-28 Prostate cancer; LUSC cis rs6089584 0.927 rs11697597 chr20:60584748 C/T cg24733560 chr20:60626293 TAF4 0.36 5.95 0.31 6.73e-9 Body mass index; LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs7178375 1.000 rs28881289 chr15:31223955 A/G cg04373760 chr16:53404718 NA 0.63 8.78 0.43 8.35e-17 Hypertriglyceridemia; LUSC cis rs950776 0.518 rs8025429 chr15:78836362 G/A cg22563815 chr15:78856949 CHRNA5 -0.26 -6.2 -0.32 1.7e-9 Sudden cardiac arrest; LUSC cis rs4319547 0.656 rs10773075 chr12:122814236 G/A cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.24 -0.41 3.91e-15 Body mass index; LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg19318889 chr4:1322082 MAEA -0.47 -7.62 -0.38 2.69e-13 Obesity-related traits; LUSC cis rs6084875 0.840 rs2077519 chr20:4720750 A/G cg26097573 chr20:4721490 PRNT -0.31 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.51 -7.5 -0.38 5.92e-13 Gut microbiome composition (summer); LUSC cis rs1568889 1.000 rs12803655 chr11:28060785 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg03676636 chr4:99064102 C4orf37 0.29 6.37 0.33 6.31e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs7216064 1.000 rs58551145 chr17:65837235 A/G cg12091567 chr17:66097778 LOC651250 -0.75 -9.43 -0.46 6.89e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs17227506 0.704 rs13263028 chr8:13453490 C/A cg03566418 chr8:13424080 C8orf48 0.4 6.02 0.31 4.53e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs950776 0.752 rs7182583 chr15:78899210 G/C cg06917634 chr15:78832804 PSMA4 0.65 10.55 0.5 1.23e-22 Sudden cardiac arrest; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14671004 chr19:39227758 CAPN12 0.45 6.99 0.36 1.52e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg00074818 chr8:8560427 CLDN23 0.58 9.78 0.47 4.93e-20 Obesity-related traits; LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg05025164 chr4:1340916 KIAA1530 0.46 7.07 0.36 9.08e-12 Obesity-related traits; LUSC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg07716408 chr11:68623521 NA -0.29 -5.68 -0.3 2.97e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs68170813 0.559 rs75313693 chr7:106863170 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC trans rs208520 0.802 rs851600 chr6:66893754 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -15.34 -0.64 1.44e-40 Exhaled nitric oxide output; LUSC cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg26384229 chr12:38710491 ALG10B -0.81 -14.09 -0.61 9.99e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs907612 0.638 rs907613 chr11:1874292 G/A cg05305434 chr11:1874049 LSP1 0.34 6.17 0.32 1.95e-9 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs12313068 0.709 rs10849698 chr12:110504798 C/G cg12870014 chr12:110450643 ANKRD13A 0.66 9.66 0.47 1.25e-19 Intelligence (multi-trait analysis); LUSC cis rs8062405 1.000 rs80275162 chr16:28863517 T/A cg05966235 chr16:28915196 ATP2A1 0.32 5.7 0.3 2.59e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg16339924 chr4:17578868 LAP3 0.67 10.34 0.49 6.19e-22 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2439831 0.867 rs2899082 chr15:43656043 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 4.03e-19 Lung cancer in ever smokers; LUSC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.34 -0.49 6.17e-22 Gut microbiome composition (summer); LUSC cis rs709400 1.000 rs3915733 chr14:104147353 G/A cg24130564 chr14:104152367 KLC1 -0.54 -7.86 -0.4 5.23e-14 Body mass index; LUSC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg04944784 chr2:26401820 FAM59B -0.72 -9.88 -0.48 2.35e-20 Gut microbiome composition (summer); LUSC cis rs75920871 0.702 rs7946869 chr11:116963312 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.52 -5.83 -0.3 1.29e-8 Subjective well-being; LUSC cis rs9788682 0.747 rs7177514 chr15:78907406 C/G cg24631222 chr15:78858424 CHRNA5 0.61 8.54 0.42 4.97e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg18479299 chr3:125709523 NA -0.5 -5.67 -0.3 3.03e-8 Blood pressure (smoking interaction); LUSC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg03609598 chr5:56110824 MAP3K1 -0.42 -5.96 -0.31 6.37e-9 Initial pursuit acceleration; LUSC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg27121462 chr16:89883253 FANCA 0.58 9.47 0.46 5.2e-19 Vitiligo; LUSC cis rs859767 0.741 rs4954155 chr2:135383504 T/C cg12500956 chr2:135428796 TMEM163 -0.28 -6.23 -0.32 1.42e-9 Neuroticism; LUSC trans rs35110281 0.748 rs4997353 chr21:45002329 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 9.0 0.44 1.79e-17 Mean corpuscular volume; LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.28 0.45 2.15e-18 Prudent dietary pattern; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02690643 chr2:139259163 SPOPL -0.46 -7.14 -0.36 5.71e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg12573674 chr2:1569213 NA -0.55 -6.13 -0.32 2.52e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg22166914 chr1:53195759 ZYG11B 0.69 11.53 0.53 4.03e-26 Monocyte count; LUSC cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.49 -9.35 -0.46 1.34e-18 Axial length; LUSC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg16339924 chr4:17578868 LAP3 0.51 7.83 0.39 6.63e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg11494091 chr17:61959527 GH2 0.4 7.03 0.36 1.18e-11 Height; LUSC cis rs9341808 0.718 rs3805920 chr6:80892745 T/C cg08355045 chr6:80787529 NA 0.58 10.07 0.48 5.31e-21 Sitting height ratio; LUSC trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs4953076 0.574 rs4953074 chr2:44464629 C/T cg04920474 chr2:44395004 PPM1B 0.6 7.83 0.39 6.63e-14 Height; LUSC cis rs12421382 0.511 rs2212430 chr11:109289538 C/T cg11473876 chr11:109292803 C11orf87 0.37 5.67 0.3 3.06e-8 Schizophrenia; LUSC trans rs72674100 1.000 rs2002117 chr4:97992122 C/T cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7584330 0.554 rs80151891 chr2:238398826 G/T cg14458575 chr2:238380390 NA 0.71 8.53 0.42 5.19e-16 Prostate cancer; LUSC cis rs61931739 0.500 rs11053277 chr12:34553835 T/A cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs1215050 0.791 rs260899 chr4:98707046 G/A cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.39e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg10792982 chr14:105748885 BRF1 0.49 8.53 0.42 5.15e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs738322 0.804 rs4821742 chr22:38514839 T/C cg25457927 chr22:38595422 NA -0.35 -6.82 -0.35 4.17e-11 Cutaneous nevi; LUSC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg23719950 chr11:63933701 MACROD1 -0.58 -7.72 -0.39 1.33e-13 Mean platelet volume; LUSC cis rs273573 1.000 rs273571 chr11:30911936 C/G cg14844989 chr11:31128820 NA 0.35 5.68 0.3 2.87e-8 Total body bone mineral density; LUSC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs3760982 1.000 rs11665924 chr19:44286982 G/A cg11993925 chr19:44307056 LYPD5 0.28 6.25 0.32 1.25e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs2387326 0.717 rs12266400 chr10:129944536 C/G cg16087940 chr10:129947807 NA 0.4 6.15 0.32 2.16e-9 Select biomarker traits; LUSC trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.48 6.25 0.32 1.26e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9807989 0.765 rs6704565 chr2:102967431 G/A cg09003973 chr2:102972529 NA 0.45 6.19 0.32 1.8e-9 Asthma; LUSC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg26408565 chr15:76604113 ETFA -0.51 -8.18 -0.41 5.95e-15 Blood metabolite levels; LUSC cis rs2729354 1.000 rs2848630 chr11:57356907 T/C cg24343310 chr11:57249947 NA 0.36 6.47 0.33 3.4e-10 Blood protein levels; LUSC cis rs2742234 0.656 rs1864400 chr10:43610366 G/A cg15436174 chr10:43711423 RASGEF1A -0.45 -7.52 -0.38 5.21e-13 Hirschsprung disease; LUSC cis rs7659604 0.521 rs4833234 chr4:122694799 T/C cg20573242 chr4:122745356 CCNA2 -0.43 -6.25 -0.32 1.25e-9 Type 2 diabetes; LUSC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg21724239 chr8:58056113 NA 0.58 6.7 0.34 8.97e-11 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg05489143 chr3:40498640 RPL14 0.41 7.29 0.37 2.22e-12 Triglycerides; LUSC trans rs10432489 0.708 rs10178270 chr2:181773395 G/C cg07312954 chr1:153914453 DENND4B -0.83 -6.07 -0.32 3.54e-9 QT interval; LUSC cis rs8060686 0.641 rs7201742 chr16:68099821 T/G cg27539214 chr16:67997921 SLC12A4 -0.54 -7.43 -0.38 9e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs10904908 0.862 rs359279 chr10:17319115 C/T cg01003015 chr10:17271136 VIM 0.4 5.89 0.31 9.43e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg05283184 chr6:79620031 NA -0.58 -12.21 -0.56 1.39e-28 Intelligence (multi-trait analysis); LUSC trans rs208520 0.955 rs12202599 chr6:67001573 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.82 10.14 0.49 3.14e-21 Exhaled nitric oxide output; LUSC cis rs7202877 0.706 rs40217 chr16:75480066 C/A cg03315344 chr16:75512273 CHST6 -0.45 -6.3 -0.33 9.63e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg12927641 chr6:109611667 NA -0.34 -5.77 -0.3 1.81e-8 Reticulocyte fraction of red cells; LUSC cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg26373071 chr5:1325741 CLPTM1L 0.39 7.06 0.36 9.72e-12 Lung cancer; LUSC cis rs477692 1.000 rs506274 chr10:131409392 T/A cg11019008 chr10:131425282 MGMT 0.47 7.06 0.36 9.87e-12 Response to temozolomide; LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.77 0.3 1.77e-8 Menopause (age at onset); LUSC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg12560992 chr17:57184187 TRIM37 -0.85 -15.08 -0.64 1.45e-39 Intelligence (multi-trait analysis); LUSC cis rs68149176 0.772 rs997762 chr16:87879562 C/A cg03553613 chr16:87879502 SLC7A5 -0.43 -5.66 -0.3 3.27e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6901250 0.655 rs636252 chr6:117157774 A/G cg12892004 chr6:117198278 RFX6 -0.4 -7.57 -0.38 3.59e-13 C-reactive protein levels; LUSC trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg20290983 chr6:43655470 MRPS18A -1.05 -23.43 -0.79 1.68e-72 IgG glycosylation; LUSC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg15744005 chr10:104629667 AS3MT -0.29 -6.26 -0.32 1.17e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs666930 0.967 rs637868 chr1:120257110 A/G cg19096424 chr1:120255104 PHGDH 0.4 6.25 0.32 1.22e-9 Breast cancer; LUSC cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.38 6.26 0.32 1.17e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12421382 0.543 rs11213094 chr11:109357926 G/A cg16359550 chr11:109292809 C11orf87 0.48 8.13 0.41 8.71e-15 Schizophrenia; LUSC cis rs9323205 0.677 rs61987261 chr14:51723879 G/A cg23942311 chr14:51606299 NA -0.39 -7.25 -0.37 2.92e-12 Cancer; LUSC cis rs7481584 0.624 rs451060 chr11:3056389 G/A cg08508325 chr11:3079039 CARS 0.38 8.46 0.42 8.77e-16 Calcium levels; LUSC trans rs941408 1.000 rs2260416 chr19:2796355 G/A cg22153745 chr1:153894579 GATAD2B -0.54 -8.34 -0.42 2.04e-15 Total cholesterol levels; LUSC cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.88 0.4 4.64e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9549367 0.789 rs35569628 chr13:113872712 T/C cg18105134 chr13:113819100 PROZ -0.69 -10.38 -0.49 4.45e-22 Platelet distribution width; LUSC trans rs7824557 0.564 rs2736294 chr8:11234626 T/C cg08975724 chr8:8085496 FLJ10661 -0.42 -6.21 -0.32 1.56e-9 Retinal vascular caliber; LUSC cis rs10857712 0.904 rs7083614 chr10:135226236 G/A cg01444801 chr10:135216882 MTG1 -0.51 -6.75 -0.35 6.46e-11 Systemic lupus erythematosus; LUSC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg03433033 chr1:76189801 ACADM 0.84 15.34 0.64 1.48e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs921968 0.643 rs532475 chr2:219434208 C/T cg02176678 chr2:219576539 TTLL4 0.64 11.85 0.54 2.83e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs4478858 0.735 rs6670067 chr1:31842947 C/T cg00250761 chr1:31883323 NA -0.35 -8.32 -0.41 2.22e-15 Alcohol dependence; LUSC trans rs11098499 0.863 rs6534139 chr4:120449456 A/G cg25214090 chr10:38739885 LOC399744 -0.55 -7.95 -0.4 2.84e-14 Corneal astigmatism; LUSC cis rs3772130 0.962 rs17742508 chr3:121559895 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.68 9.91 0.48 1.88e-20 Cognitive performance; LUSC cis rs9611565 0.918 rs28638318 chr22:41753059 G/A cg06634786 chr22:41940651 POLR3H -0.48 -5.75 -0.3 2.04e-8 Vitiligo; LUSC cis rs4319547 0.737 rs10773176 chr12:122944713 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.86 -0.44 4.89e-17 Body mass index; LUSC cis rs12291225 0.679 rs1043237 chr11:14289053 A/T cg19336497 chr11:14380999 RRAS2 -0.56 -10.76 -0.51 2.29e-23 Sense of smell; LUSC cis rs9303401 0.703 rs9909925 chr17:57210069 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.54 -8.32 -0.41 2.34e-15 Cognitive test performance; LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg10117171 chr1:25599238 RHD -0.38 -5.82 -0.3 1.36e-8 Erythrocyte sedimentation rate; LUSC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg00409905 chr10:38381863 ZNF37A 0.35 6.12 0.32 2.64e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg22709100 chr7:91322751 NA 0.39 5.8 0.3 1.56e-8 Breast cancer; LUSC cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.67 0.3 3.05e-8 Rheumatoid arthritis; LUSC cis rs9467773 0.620 rs2130657 chr6:26650826 C/T cg05738196 chr6:26577821 NA 0.79 14.91 0.63 6.82e-39 Intelligence (multi-trait analysis); LUSC cis rs9311676 0.632 rs11130637 chr3:58405573 C/G cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.1e-10 Systemic lupus erythematosus; LUSC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg00074818 chr8:8560427 CLDN23 0.58 9.81 0.47 3.98e-20 Obesity-related traits; LUSC cis rs7100689 0.646 rs4357632 chr10:82131783 C/T cg01528321 chr10:82214614 TSPAN14 0.86 13.08 0.58 7.25e-32 Post bronchodilator FEV1; LUSC cis rs72634258 0.554 rs4908694 chr1:7850898 C/T cg26816564 chr1:7831052 VAMP3 0.93 13.38 0.59 5.54e-33 Inflammatory bowel disease; LUSC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.01e-11 Tonsillectomy; LUSC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs2070433 0.904 rs11701571 chr21:47963149 A/G cg12379764 chr21:47803548 PCNT 0.64 8.1 0.41 1.06e-14 Lymphocyte counts; LUSC cis rs9682041 0.877 rs10755126 chr3:170071694 C/G cg11886554 chr3:170076028 SKIL -0.73 -9.1 -0.45 8.39e-18 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg00484396 chr16:3507460 NAT15 0.48 7.26 0.37 2.78e-12 Body mass index (adult); LUSC cis rs6692729 0.901 rs4653470 chr1:227082726 T/A cg10327440 chr1:227177885 CDC42BPA -0.5 -7.06 -0.36 9.96e-12 Electrodermal activity; LUSC cis rs1153858 1.000 rs2668747 chr15:45617216 T/C cg26924012 chr15:45694286 SPATA5L1 1.13 19.69 0.73 7.64e-58 Homoarginine levels; LUSC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg02569458 chr12:86230093 RASSF9 -0.5 -8.56 -0.42 4.06e-16 Major depressive disorder; LUSC cis rs17095355 1.000 rs9630101 chr10:111738451 T/C cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.36 -0.37 1.43e-12 Biliary atresia; LUSC cis rs7119 0.717 rs11629652 chr15:77779951 C/A cg05673287 chr15:77411982 SGK269 -0.43 -6.89 -0.35 2.76e-11 Type 2 diabetes; LUSC trans rs1908814 0.516 rs10113145 chr8:11793295 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.61e-9 Neuroticism; LUSC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs478304 0.651 rs948493 chr11:65552154 C/T cg05805236 chr11:65401703 PCNXL3 -0.56 -8.86 -0.44 4.89e-17 Acne (severe); LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg12412775 chr1:25698385 RHCE -0.29 -5.94 -0.31 7.29e-9 Erythrocyte sedimentation rate; LUSC trans rs10506458 0.834 rs58821476 chr12:63389425 T/C cg22491629 chr6:157744540 C6orf35 -0.91 -10.85 -0.51 1.06e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs17253792 0.730 rs77079997 chr14:56155250 A/G cg01858014 chr14:56050164 KTN1 -0.73 -6.26 -0.32 1.18e-9 Putamen volume; LUSC cis rs9790314 0.967 rs336541 chr3:161056698 A/C cg04691961 chr3:161091175 C3orf57 -0.35 -6.11 -0.32 2.74e-9 Morning vs. evening chronotype; LUSC trans rs1728785 0.901 rs821169 chr16:68630184 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.72 0.39 1.39e-13 Ulcerative colitis; LUSC cis rs7584330 0.955 rs58643200 chr2:238389855 A/G cg14458575 chr2:238380390 NA 0.68 11.58 0.54 2.63e-26 Prostate cancer; LUSC cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.4 5.98 0.31 5.85e-9 Schizophrenia; LUSC cis rs826838 0.967 rs826876 chr12:39123843 T/C cg13010199 chr12:38710504 ALG10B -0.64 -10.94 -0.51 5.0600000000000004e-24 Heart rate; LUSC cis rs9362426 1.000 rs173334 chr6:88080223 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.38 6.18 0.32 1.9e-9 Depressive episodes in bipolar disorder; LUSC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.36 0.56 3.74e-29 Cognitive test performance; LUSC cis rs73206853 0.563 rs7968913 chr12:111138558 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 6.64 0.34 1.29e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7589342 0.929 rs2060036 chr2:106436101 G/A cg14210321 chr2:106509881 NCK2 -0.55 -8.15 -0.41 7.61e-15 Addiction; LUSC cis rs7582720 1.000 rs72936882 chr2:203794439 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs765787 0.530 rs4775834 chr15:45537511 C/T cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg03351412 chr1:154909251 PMVK -0.51 -7.64 -0.39 2.28e-13 Prostate cancer; LUSC cis rs9796 0.835 rs2927062 chr15:41302687 A/G cg18705301 chr15:41695430 NDUFAF1 -0.46 -8.12 -0.41 8.92e-15 Menopause (age at onset); LUSC cis rs9325144 0.560 rs11183090 chr12:38662293 G/C cg26384229 chr12:38710491 ALG10B -0.67 -10.52 -0.5 1.46e-22 Morning vs. evening chronotype; LUSC trans rs11039798 0.614 rs11039954 chr11:48741818 A/G cg03929089 chr4:120376271 NA 0.74 6.91 0.35 2.4e-11 Axial length; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24201716 chr10:115933917 C10orf118;MIR2110 -0.4 -6.13 -0.32 2.5e-9 Electrocardiographic conduction measures; LUSC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg06108461 chr20:60628389 TAF4 -1.01 -17.18 -0.68 7.43e-48 Body mass index; LUSC cis rs6542838 0.641 rs6724477 chr2:99537074 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.46 6.32 0.33 8.54e-10 Fear of minor pain; LUSC cis rs4588572 0.601 rs1529500 chr5:77721643 C/T cg11547950 chr5:77652471 NA -0.55 -7.91 -0.4 3.82e-14 Triglycerides; LUSC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg15691649 chr6:25882328 NA 0.5 7.52 0.38 5.12e-13 Blood metabolite levels; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg13770088 chr11:32851361 PRRG4 -0.39 -5.96 -0.31 6.28e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7824557 0.564 rs7839307 chr8:11198792 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.04 0.31 4.08e-9 Retinal vascular caliber; LUSC trans rs3942852 0.955 rs1503190 chr11:48117873 A/G cg15704280 chr7:45808275 SEPT13 -0.54 -6.26 -0.32 1.22e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs17125944 0.505 rs10483618 chr14:53203590 T/C cg13660082 chr14:53194042 PSMC6 -0.79 -6.95 -0.36 1.97e-11 Alzheimer's disease (late onset); LUSC cis rs11048434 0.736 rs2041624 chr12:9111855 C/G cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC trans rs877282 0.898 rs12356744 chr10:757477 G/C cg22713356 chr15:30763199 NA 1.03 13.61 0.6 7.56e-34 Uric acid levels; LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg05368731 chr17:41323189 NBR1 0.93 15.77 0.65 2.76e-42 Menopause (age at onset); LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16787284 chr2:242255278 SEPT2;HDLBP -0.42 -6.16 -0.32 2.06e-9 Electrocardiographic conduction measures; LUSC cis rs2274273 0.837 rs56949365 chr14:55790078 T/C cg04306507 chr14:55594613 LGALS3 0.54 11.81 0.54 3.98e-27 Protein biomarker; LUSC cis rs1371867 0.846 rs1788191 chr8:101260844 C/T cg06002616 chr8:101225028 SPAG1 0.44 7.26 0.37 2.71e-12 Atrioventricular conduction; LUSC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.85 -0.3 1.15e-8 Extrinsic epigenetic age acceleration; LUSC trans rs62344088 1.000 rs7715867 chr5:129059 C/T cg11454300 chr2:2256402 MYT1L 0.75 6.03 0.31 4.35e-9 Asthma (childhood onset); LUSC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.4 6.35 0.33 6.88e-10 Cystic fibrosis severity; LUSC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg06221963 chr1:154839813 KCNN3 -0.63 -14.54 -0.62 1.83e-37 Prostate cancer; LUSC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg26566898 chr11:117069891 TAGLN 0.45 7.42 0.38 9.69e-13 Blood protein levels; LUSC cis rs7712401 0.623 rs30057 chr5:122298118 C/T cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs4595586 0.545 rs12827197 chr12:39404362 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.11 0.32 2.75e-9 Morning vs. evening chronotype; LUSC cis rs6500602 0.702 rs1051308 chr16:4560301 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.52 -6.95 -0.36 1.93e-11 Schizophrenia; LUSC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg16989086 chr20:62203971 PRIC285 0.45 6.3 0.33 9.31e-10 Glioblastoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11239019 chr17:40172096 NKIRAS2 0.68 5.95 0.31 6.82e-9 Cognitive performance; LUSC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg18350739 chr11:68623251 NA -0.38 -6.45 -0.33 3.95e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg01879757 chr17:41196368 BRCA1 -0.39 -5.9 -0.31 8.83e-9 Menopause (age at onset); LUSC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.47 -6.14 -0.32 2.28e-9 Renal function-related traits (BUN); LUSC cis rs34779708 0.733 rs7081597 chr10:35546331 G/C cg03585969 chr10:35415529 CREM 0.54 7.67 0.39 1.89e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8141529 0.778 rs7287806 chr22:29213011 G/A cg15103426 chr22:29168792 CCDC117 0.58 7.91 0.4 3.73e-14 Lymphocyte counts; LUSC cis rs887829 0.641 rs7586110 chr2:234590527 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -6.55 -0.34 2.23e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs11051970 0.659 rs1809913 chr12:32591626 A/G cg02745156 chr12:32552066 NA 0.38 5.87 0.31 1.05e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg26380479 chr7:97908229 NA -0.28 -6.15 -0.32 2.26e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.84 0.51 1.17e-23 Menopause (age at onset); LUSC cis rs1048238 0.506 rs56352596 chr1:16297592 G/A cg22431228 chr1:16359049 CLCNKA -0.4 -8.17 -0.41 6.56e-15 Systolic blood pressure; LUSC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg12257692 chr3:49977190 RBM6 0.25 6.92 0.35 2.29e-11 Intelligence (multi-trait analysis); LUSC cis rs7589342 0.536 rs7562892 chr2:106396212 C/T cg09152813 chr2:106391379 NCK2 -0.39 -6.29 -0.33 1e-9 Addiction; LUSC cis rs2177596 0.534 rs3923085 chr2:227948746 C/T cg11843606 chr2:227700838 RHBDD1 -0.44 -5.68 -0.3 2.92e-8 Body mass index; LUSC cis rs6845621 0.870 rs1377150 chr4:18922754 C/G cg12196642 chr4:18937545 NA 0.34 6.42 0.33 4.68e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs17292804 0.527 rs12887734 chr14:104046834 G/T cg08213375 chr14:104286397 PPP1R13B 0.35 5.96 0.31 6.27e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs72781680 1.000 rs72781679 chr2:24237712 G/A cg20701182 chr2:24300061 SF3B14 0.77 7.87 0.4 4.89e-14 Lymphocyte counts; LUSC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.82 0.47 3.61e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.19 0.45 4.24e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6669072 0.565 rs35797670 chr1:91267334 T/C cg08895590 chr1:91227319 NA -0.27 -5.75 -0.3 1.99e-8 Cognitive function; LUSC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg27572855 chr1:25598939 RHD 0.45 8.13 0.41 8.56e-15 Erythrocyte sedimentation rate; LUSC cis rs28647808 0.881 rs28625799 chr9:136264557 C/T cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 14.07 0.61 1.24e-35 Platelet count; LUSC cis rs9325144 0.505 rs826893 chr12:39100536 A/G cg26384229 chr12:38710491 ALG10B -0.79 -13.74 -0.6 2.34e-34 Morning vs. evening chronotype; LUSC cis rs7824557 0.707 rs3808519 chr8:11142970 C/G cg21775007 chr8:11205619 TDH 0.71 11.75 0.54 6.7399999999999993e-27 Retinal vascular caliber; LUSC cis rs7131987 0.650 rs11050208 chr12:29510369 T/G cg09582351 chr12:29534625 ERGIC2 -0.34 -6.61 -0.34 1.54e-10 QT interval; LUSC cis rs7681440 0.715 rs17016305 chr4:90791381 A/G cg01966878 chr4:90757139 SNCA -0.36 -5.9 -0.31 8.77e-9 Dementia with Lewy bodies; LUSC cis rs8025790 0.508 rs12441823 chr15:67912977 C/T cg24579218 chr15:68104479 NA -0.36 -5.86 -0.31 1.1e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs4961252 0.505 rs12680168 chr8:142102522 A/T cg13924514 chr8:142070760 NA -0.34 -5.66 -0.3 3.26e-8 Isovolumetric relaxation time;Response to interferon beta therapy; LUSC trans rs10506458 0.915 rs12424908 chr12:63402364 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -15.95 -0.66 5.6e-43 Hemostatic factors and hematological phenotypes; LUSC cis rs9309711 0.961 rs11686236 chr2:3471549 G/A cg10845886 chr2:3471009 TTC15 -0.63 -8.23 -0.41 4.18e-15 Neurofibrillary tangles; LUSC trans rs7618501 0.635 rs34080578 chr3:50026029 A/C cg21659725 chr3:3221576 CRBN 0.63 10.36 0.49 5.2e-22 Intelligence (multi-trait analysis); LUSC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg25811766 chr13:21894605 NA 0.67 11.15 0.52 9.21e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg20848291 chr7:100343083 ZAN 0.39 6.05 0.31 3.89e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs8014204 0.762 rs2359237 chr14:75245002 G/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.14 0.41 7.77e-15 Caffeine consumption; LUSC trans rs853679 1.000 rs1778511 chr6:28229411 G/A cg06606381 chr12:133084897 FBRSL1 0.57 6.49 0.33 3.17e-10 Depression; LUSC cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg25182066 chr10:30743637 MAP3K8 -0.42 -6.06 -0.31 3.58e-9 Inflammatory bowel disease; LUSC cis rs7586879 0.964 rs4077680 chr2:25122942 A/G cg15423357 chr2:25149977 NA 0.35 6.42 0.33 4.64e-10 Body mass index; LUSC trans rs9401746 0.564 rs659343 chr6:124803351 T/C cg16857858 chr7:27213984 HOXA10 0.54 6.09 0.32 3.11e-9 Bone mineral density (Ward's triangle area); LUSC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg13206674 chr6:150067644 NUP43 0.57 8.99 0.44 1.91e-17 Lung cancer; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg23873654 chr17:26733358 SLC46A1 0.41 6.38 0.33 5.91e-10 Educational attainment (years of education); LUSC cis rs61931739 0.635 rs10743837 chr12:33982162 A/G cg06521331 chr12:34319734 NA -0.42 -6.97 -0.36 1.67e-11 Morning vs. evening chronotype; LUSC cis rs9467773 0.935 rs9461270 chr6:26544110 A/G cg09904177 chr6:26538194 HMGN4 0.75 14.27 0.62 2.05e-36 Intelligence (multi-trait analysis); LUSC cis rs7590368 1.000 rs13429247 chr2:10960529 A/G cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs17270561 0.609 rs7754296 chr6:25744878 A/G cg16482183 chr6:26056742 HIST1H1C 0.6 8.56 0.42 4.07e-16 Iron status biomarkers; LUSC cis rs7124681 0.528 rs74608150 chr11:47696214 A/T cg20307385 chr11:47447363 PSMC3 0.46 6.72 0.35 7.85e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg20135002 chr11:47629003 NA -0.52 -8.12 -0.41 8.82e-15 Subjective well-being; LUSC cis rs59698941 0.943 rs67462411 chr5:132220031 C/T cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.45e-11 Apolipoprotein A-IV levels; LUSC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs501916 0.634 rs1561479 chr15:48070157 C/G cg16110827 chr15:48056943 SEMA6D -0.38 -6.01 -0.31 4.9e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs9640161 0.711 rs10259796 chr7:150050427 T/C cg27494647 chr7:150038898 RARRES2 0.46 6.96 0.36 1.77e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs11018904 0.906 rs35286339 chr11:89965679 A/G cg26138821 chr11:89956704 CHORDC1 -0.58 -7.18 -0.37 4.67e-12 Intelligence (multi-trait analysis); LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg02423579 chr7:2872169 GNA12 -0.48 -7.04 -0.36 1.08e-11 Height; LUSC cis rs858239 0.632 rs6952947 chr7:23121042 C/G cg23682824 chr7:23144976 KLHL7 -0.39 -5.79 -0.3 1.67e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.53 0.38 4.72e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg20283391 chr11:68216788 NA -0.57 -8.14 -0.41 7.95e-15 Total body bone mineral density; LUSC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg13607699 chr17:42295918 UBTF 0.52 7.9 0.4 4.06e-14 Total body bone mineral density; LUSC cis rs11630290 0.736 rs4777239 chr15:64148098 T/A cg12036633 chr15:63758958 NA 0.6 6.74 0.35 6.79e-11 Iris characteristics; LUSC cis rs703842 0.616 rs10877023 chr12:58224199 C/A cg00677455 chr12:58241039 CTDSP2 0.71 11.07 0.52 1.74e-24 Multiple sclerosis; LUSC cis rs983392 0.679 rs636341 chr11:60019161 A/C cg20284999 chr11:59952153 MS4A6A 0.39 6.55 0.34 2.16e-10 Alzheimer's disease (late onset); LUSC cis rs12474201 0.928 rs13429704 chr2:46960329 G/T cg06386533 chr2:46925753 SOCS5 0.73 11.1 0.52 1.46e-24 Height; LUSC cis rs73198271 0.700 rs10090152 chr8:8652104 C/A cg15556689 chr8:8085844 FLJ10661 -0.45 -5.88 -0.31 9.95e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12893668 0.703 rs34026011 chr14:104050883 G/A cg04998671 chr14:104000505 TRMT61A -0.47 -6.95 -0.36 1.92e-11 Reticulocyte count; LUSC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg03929089 chr4:120376271 NA -0.94 -16.48 -0.67 4.53e-45 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00244654 chr2:9983430 TAF1B -0.42 -6.29 -0.33 1.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9287719 0.967 rs6432126 chr2:10757101 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg26314531 chr2:26401878 FAM59B -0.69 -9.3 -0.45 1.95e-18 Gut microbiome composition (summer); LUSC cis rs1797885 0.651 rs1552485 chr3:12580283 C/T cg09856107 chr3:12701776 RAF1 0.31 5.69 0.3 2.73e-8 Immature fraction of reticulocytes; LUSC trans rs800082 0.690 rs2717392 chr3:144280080 T/C cg24215973 chr2:240111563 HDAC4 0.59 9.33 0.45 1.54e-18 Smoking behavior; LUSC cis rs1801251 0.778 rs812383 chr2:233737132 C/A cg25237894 chr2:233734115 C2orf82 -0.35 -6.65 -0.34 1.18e-10 Coronary artery disease; LUSC cis rs7681440 0.583 rs2737022 chr4:90739662 A/C cg06632027 chr4:90757378 SNCA -0.36 -5.69 -0.3 2.71e-8 Dementia with Lewy bodies; LUSC cis rs9648716 0.515 rs2930322 chr7:140424582 G/C cg23214464 chr7:140373596 ADCK2 0.75 6.15 0.32 2.2e-9 Type 2 diabetes; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg22638593 chr5:131593259 PDLIM4 0.41 5.96 0.31 6.45e-9 Acylcarnitine levels; LUSC cis rs6964587 0.934 rs1544377 chr7:91687351 A/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs12908161 0.683 rs12903256 chr15:85308141 G/T cg12863693 chr15:85201151 NMB 0.3 6.61 0.34 1.56e-10 Schizophrenia; LUSC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg06713675 chr4:122721982 EXOSC9 -0.46 -8.07 -0.4 1.27e-14 Type 2 diabetes; LUSC cis rs2274273 0.624 rs7150763 chr14:55839801 A/G cg04306507 chr14:55594613 LGALS3 0.49 9.98 0.48 1.04e-20 Protein biomarker; LUSC cis rs8044995 0.563 rs56220628 chr16:68384837 G/A cg05110241 chr16:68378359 PRMT7 -0.76 -8.86 -0.44 4.68e-17 Schizophrenia; LUSC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC trans rs62458065 0.513 rs9655340 chr7:32535920 A/G cg00845942 chr12:64062724 DPY19L2 0.6 7.63 0.39 2.49e-13 Metabolite levels (HVA/MHPG ratio); LUSC cis rs8078723 1.000 rs8070454 chr17:38160754 C/T cg17467752 chr17:38218738 THRA 0.78 12.64 0.57 3.5e-30 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs3820928 0.845 rs10165767 chr2:227781863 G/A cg11843606 chr2:227700838 RHBDD1 -0.55 -8.01 -0.4 1.99e-14 Pulmonary function; LUSC cis rs6938 0.597 rs4886641 chr15:75228655 C/A cg03289416 chr15:75166202 SCAMP2 0.45 6.71 0.34 8.6e-11 Breast cancer; LUSC cis rs8060686 0.920 rs16942887 chr16:67928042 G/A cg27539214 chr16:67997921 SLC12A4 -0.45 -5.99 -0.31 5.44e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4660261 0.526 rs2485997 chr1:44345841 G/C cg13246856 chr1:44399776 ARTN 0.29 6.23 0.32 1.4e-9 Intelligence (multi-trait analysis); LUSC cis rs1865760 0.786 rs1436308 chr6:25939567 T/G cg17691542 chr6:26056736 HIST1H1C 0.5 7.26 0.37 2.71e-12 Height; LUSC cis rs12530845 0.887 rs79100776 chr7:135315817 G/A cg23117316 chr7:135346802 PL-5283 -0.58 -9.31 -0.45 1.82e-18 Red blood cell traits; LUSC trans rs12200782 1.000 rs4292511 chr6:26622290 G/T cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC cis rs2559856 1.000 rs2559860 chr12:102087636 C/T cg12924262 chr12:102091054 CHPT1 0.43 6.11 0.32 2.71e-9 Blood protein levels; LUSC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg19912559 chr1:40204330 PPIE 0.51 7.78 0.39 8.95e-14 Blood protein levels; LUSC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC cis rs9650657 0.836 rs1073913 chr8:10611708 A/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.16 -0.32 2.08e-9 Neuroticism; LUSC trans rs11098499 0.542 rs7677836 chr4:120310638 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.596 rs11057202 chr12:123720775 G/T cg00376283 chr12:123451042 ABCB9 0.69 9.81 0.47 3.98e-20 Neutrophil percentage of white cells; LUSC cis rs11209002 0.592 rs6672126 chr1:67558063 C/G cg02640540 chr1:67518911 SLC35D1 0.64 9.04 0.44 1.28e-17 Crohn's disease; LUSC cis rs4663866 0.901 rs2304672 chr2:239186589 C/G cg16914508 chr2:239161102 PER2 -0.66 -7.31 -0.37 2e-12 Irritable bowel syndrome; LUSC cis rs10208940 0.841 rs6731066 chr2:68796618 A/G cg12452813 chr2:68675892 NA 0.6 6.1 0.32 2.99e-9 Urate levels in lean individuals; LUSC cis rs7560272 0.723 rs7562047 chr2:73725168 G/T cg20560298 chr2:73613845 ALMS1 -0.46 -7.2 -0.37 4.06e-12 Schizophrenia; LUSC cis rs1957429 0.808 rs4899150 chr14:65344400 A/G cg23373153 chr14:65346875 NA 0.94 10.65 0.5 5.2e-23 Pediatric areal bone mineral density (radius); LUSC cis rs7107174 1.000 rs10501426 chr11:78057122 C/T cg02023728 chr11:77925099 USP35 0.44 6.72 0.35 7.74e-11 Testicular germ cell tumor; LUSC cis rs738322 0.870 rs5750558 chr22:38582497 G/A cg25457927 chr22:38595422 NA 0.44 9.3 0.45 1.82e-18 Cutaneous nevi; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg01125463 chr6:42946178 PEX6 -0.35 -5.7 -0.3 2.6e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg24531977 chr5:56204891 C5orf35 -1.05 -15.51 -0.65 2.96e-41 Initial pursuit acceleration; LUSC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg02574844 chr11:5959923 NA -0.41 -5.81 -0.3 1.42e-8 DNA methylation (variation); LUSC cis rs11098499 0.863 rs2291185 chr4:120434833 C/A cg09307838 chr4:120376055 NA 0.74 10.88 0.51 8.49e-24 Corneal astigmatism; LUSC cis rs7107174 1.000 rs10899467 chr11:78014057 G/T cg02023728 chr11:77925099 USP35 0.49 6.88 0.35 3.02e-11 Testicular germ cell tumor; LUSC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg11812906 chr14:75593930 NEK9 -0.62 -10.06 -0.48 5.64e-21 Height; LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg02951883 chr7:2050386 MAD1L1 -0.58 -10.63 -0.5 6.39e-23 Bipolar disorder and schizophrenia; LUSC cis rs6163 0.508 rs11191381 chr10:104493444 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.48 -6.6 -0.34 1.62e-10 Waist circumference;Hip circumference; LUSC cis rs10992471 0.603 rs1121978 chr9:95140351 T/G cg14631576 chr9:95140430 CENPP -0.37 -6.5 -0.33 3e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs11809207 0.951 rs111772533 chr1:26523404 C/G cg00300879 chr1:26503847 CNKSR1 0.3 5.78 0.3 1.76e-8 Height; LUSC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs453301 0.686 rs11787026 chr8:8902371 A/T cg15556689 chr8:8085844 FLJ10661 0.54 8.33 0.41 2.16e-15 Joint mobility (Beighton score); LUSC trans rs1814175 0.817 rs7947526 chr11:49983654 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.87 -10.55 -0.5 1.17e-22 Platelet count; LUSC cis rs12541635 1.000 rs1896918 chr8:107090500 G/A cg10147462 chr8:107024639 NA -0.48 -8.76 -0.43 1.03e-16 Age of smoking initiation; LUSC cis rs9300255 0.539 rs1969355 chr12:123742061 G/A cg13010344 chr12:123464640 ARL6IP4 -0.48 -7.22 -0.37 3.44e-12 Neutrophil percentage of white cells; LUSC cis rs3960554 0.808 rs111764601 chr7:75706141 T/C cg17325771 chr7:75508891 RHBDD2 -0.4 -5.65 -0.3 3.52e-8 Eotaxin levels; LUSC cis rs778371 0.723 rs737027 chr2:233641083 G/C cg08000102 chr2:233561755 GIGYF2 0.81 13.87 0.6 7.47e-35 Schizophrenia; LUSC cis rs1153858 1.000 rs7169818 chr15:45640191 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.2 0.41 5.08e-15 Homoarginine levels; LUSC cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.85 0.35 3.51e-11 Tonsillectomy; LUSC cis rs17807624 1.000 rs17807624 chr8:11463015 A/G cg21175976 chr8:11421337 BLK -0.35 -6.01 -0.31 4.95e-9 Systemic lupus erythematosus; LUSC cis rs2230307 0.536 rs526128 chr1:100473427 T/A cg24955406 chr1:100503596 HIAT1 0.56 6.04 0.31 4.01e-9 Carotid intima media thickness; LUSC cis rs877282 0.945 rs11253398 chr10:790012 T/C cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg18404041 chr3:52824283 ITIH1 -0.53 -9.99 -0.48 9.79e-21 Bipolar disorder; LUSC cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg25182066 chr10:30743637 MAP3K8 0.44 6.55 0.34 2.22e-10 Inflammatory bowel disease; LUSC cis rs17270561 0.609 rs1892245 chr6:25764833 G/T cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg22508957 chr16:3507546 NAT15 -0.9 -10.47 -0.5 2.18e-22 Tuberculosis; LUSC cis rs6831352 1.000 rs1126673 chr4:100045616 C/T cg12011299 chr4:100065546 ADH4 0.75 12.41 0.56 2.47e-29 Alcohol dependence; LUSC cis rs4499344 0.657 rs2868146 chr19:33050047 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.74 -9.67 -0.47 1.16e-19 Mean platelet volume; LUSC cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg21535247 chr6:8435926 SLC35B3 -0.57 -8.64 -0.43 2.29e-16 Motion sickness; LUSC cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg10523860 chr14:103875565 MARK3 -0.38 -6.19 -0.32 1.75e-9 Body mass index; LUSC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.41 -5.72 -0.3 2.38e-8 Schizophrenia; LUSC cis rs11696845 0.649 rs6031782 chr20:43383832 A/G cg25301532 chr20:43378953 KCNK15 -0.36 -6.27 -0.32 1.1e-9 Obesity-related traits; LUSC cis rs1577917 1.000 rs12190598 chr6:86686074 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -7.66 -0.39 2e-13 Response to antipsychotic treatment; LUSC cis rs2953174 1.000 rs2953176 chr2:241520754 T/A cg07929629 chr2:241523174 NA 0.46 5.82 0.3 1.39e-8 Bipolar disorder; LUSC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg05340658 chr4:99064831 C4orf37 0.68 11.61 0.54 2.11e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs2463822 0.925 rs17157227 chr11:62169772 A/G cg06239285 chr11:62104954 ASRGL1 0.94 10.25 0.49 1.3e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11702148 0.552 rs3787708 chr21:34906039 C/T cg14850771 chr21:34775459 IFNGR2 0.38 5.7 0.3 2.6e-8 Mean corpuscular hemoglobin; LUSC cis rs929596 0.755 rs887829 chr2:234668570 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.66 11.29 0.53 3.07e-25 Total bilirubin levels in HIV-1 infection; LUSC cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg19678392 chr7:94953810 PON1 -0.36 -5.65 -0.3 3.48e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7605378 1.000 rs2689766 chr2:200697539 A/T cg17644776 chr2:200775616 C2orf69 0.37 5.97 0.31 6.15e-9 Osteoporosis; LUSC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.84 0.63 1.31e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9886651 0.935 rs13248719 chr8:128802751 T/C cg07795030 chr8:128802207 NA -0.35 -6.33 -0.33 7.72e-10 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC trans rs7829975 0.593 rs2921077 chr8:8304502 C/T cg27411982 chr8:10470053 RP1L1 0.41 6.63 0.34 1.32e-10 Mood instability; LUSC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg02187348 chr16:89574699 SPG7 0.59 9.47 0.46 5.16e-19 Multiple myeloma (IgH translocation); LUSC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg12386194 chr3:101231763 SENP7 0.53 7.42 0.38 9.66e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7246657 0.551 rs62108899 chr19:37595183 C/T cg23950597 chr19:37808831 NA -0.53 -5.66 -0.3 3.24e-8 Coronary artery calcification; LUSC cis rs6424115 0.862 rs34845821 chr1:24066486 C/T cg10978503 chr1:24200527 CNR2 -0.45 -8.84 -0.44 5.71e-17 Immature fraction of reticulocytes; LUSC cis rs10823500 0.640 rs7077538 chr10:71993094 T/G cg02100629 chr10:71892760 AIFM2 -0.37 -5.9 -0.31 9.02e-9 Blood protein levels; LUSC cis rs12479064 0.505 rs62153764 chr2:99818612 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -11.61 -0.54 2.12e-26 Chronic sinus infection; LUSC trans rs4718428 1.000 rs4718428 chr7:66421446 T/G cg18876405 chr7:65276391 NA 0.49 7.8 0.39 8.19e-14 Corneal structure; LUSC cis rs10465746 0.967 rs12120160 chr1:84342835 T/G cg10977910 chr1:84465055 TTLL7 0.45 6.39 0.33 5.52e-10 Obesity-related traits; LUSC cis rs877282 0.853 rs7079299 chr10:756455 A/G cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg11060661 chr22:24314208 DDT;DDTL 0.5 8.16 0.41 6.66e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9325144 0.671 rs7486919 chr12:38767997 A/G cg26384229 chr12:38710491 ALG10B -0.61 -9.35 -0.46 1.34e-18 Morning vs. evening chronotype; LUSC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg23630131 chr7:65973040 NA -0.22 -5.99 -0.31 5.28e-9 Aortic root size; LUSC cis rs9463078 0.809 rs10948195 chr6:44957965 T/C cg25276700 chr6:44698697 NA -0.29 -5.68 -0.3 2.88e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs981844 0.712 rs4696507 chr4:154753702 G/A cg14289246 chr4:154710475 SFRP2 -0.46 -6.26 -0.32 1.16e-9 Response to statins (LDL cholesterol change); LUSC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg27141850 chr2:20869434 GDF7 -0.35 -8.09 -0.4 1.09e-14 Abdominal aortic aneurysm; LUSC cis rs11077998 0.967 rs7350963 chr17:80491067 G/A cg10255544 chr17:80519551 FOXK2 0.4 6.57 0.34 1.89e-10 Reticulocyte fraction of red cells; LUSC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg15445000 chr17:37608096 MED1 -0.39 -6.8 -0.35 4.94e-11 Glomerular filtration rate (creatinine); LUSC cis rs11190604 0.697 rs10748795 chr10:102194818 A/T cg07080220 chr10:102295463 HIF1AN -0.58 -7.93 -0.4 3.42e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg05368731 chr17:41323189 NBR1 0.93 15.63 0.65 1.01e-41 Menopause (age at onset); LUSC cis rs1865721 1.000 rs3813080 chr18:73186227 C/T cg26385618 chr18:73139727 C18orf62 -0.49 -8.13 -0.41 8.32e-15 Intelligence; LUSC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg23172400 chr8:95962367 TP53INP1 -0.4 -8.09 -0.4 1.12e-14 Type 2 diabetes; LUSC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg15145296 chr3:125709740 NA -0.58 -6.41 -0.33 4.91e-10 Blood pressure (smoking interaction); LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg21782813 chr7:2030301 MAD1L1 0.51 8.6 0.43 3.25e-16 Bipolar disorder and schizophrenia; LUSC cis rs9902453 0.899 rs8067580 chr17:28471248 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.19 0.41 5.57e-15 Coffee consumption (cups per day); LUSC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.05e-8 Reticulocyte fraction of red cells; LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg24060327 chr5:131705240 SLC22A5 0.64 11.65 0.54 1.55e-26 Breast cancer; LUSC trans rs11039798 0.688 rs8188953 chr11:48749201 A/T cg15704280 chr7:45808275 SEPT13 0.81 7.73 0.39 1.27e-13 Axial length; LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs2219968 0.962 rs1471585 chr8:78945590 C/T cg00738934 chr8:78996279 NA -0.36 -6.41 -0.33 5.04e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7954584 0.710 rs10840641 chr12:122465831 G/T cg22618164 chr12:122356400 WDR66 0.42 5.98 0.31 5.76e-9 Mean corpuscular volume; LUSC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg18876405 chr7:65276391 NA -0.56 -8.79 -0.43 8.32e-17 Aortic root size; LUSC cis rs11168618 0.846 rs7958521 chr12:48877400 G/A cg24011408 chr12:48396354 COL2A1 0.39 6.13 0.32 2.42e-9 Adiponectin levels; LUSC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.55 0.34 2.22e-10 Lung cancer; LUSC cis rs40363 1.000 rs28401 chr16:3515354 C/G cg05754148 chr16:3507555 NAT15 0.79 9.61 0.47 1.8e-19 Tuberculosis; LUSC cis rs17270561 0.609 rs9358876 chr6:25738956 A/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC cis rs79149102 0.579 rs7179097 chr15:75279240 T/G cg17294928 chr15:75287854 SCAMP5 -0.72 -5.92 -0.31 7.8e-9 Lung cancer; LUSC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg11645453 chr3:52864694 ITIH4 0.33 7.63 0.39 2.55e-13 Bipolar disorder; LUSC cis rs4824093 0.610 rs4141437 chr22:50243719 C/G cg26441486 chr22:50317300 CRELD2 -0.59 -5.69 -0.3 2.84e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC cis rs1200821 0.535 rs1208784 chr10:37768433 A/G cg25427524 chr10:38739819 LOC399744 -0.35 -5.69 -0.3 2.77e-8 Hemostatic factors and hematological phenotypes; LUSC cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.98 -0.36 1.64e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6690583 0.623 rs12042845 chr1:85429801 A/G cg11262906 chr1:85462892 MCOLN2 0.69 6.76 0.35 6.02e-11 Serum sulfate level; LUSC trans rs11039798 1.000 rs12281162 chr11:48650491 T/C cg03929089 chr4:120376271 NA 0.66 6.13 0.32 2.48e-9 Axial length; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00890378 chr1:33816159 PHC2 0.38 5.98 0.31 5.68e-9 Asthma; LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg12564285 chr5:131593104 PDLIM4 0.46 8.23 0.41 4.12e-15 Breast cancer; LUSC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg11301795 chr4:187892539 NA -0.8 -15.5 -0.65 3.24e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs77686669 1 rs77686669 chr7:99744572 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.43 6.2 0.32 1.63e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg21906852 chr1:75198582 TYW3;CRYZ 0.36 5.7 0.3 2.62e-8 Resistin levels; LUSC cis rs66887589 0.777 rs1814815 chr4:120258091 C/T cg09307838 chr4:120376055 NA 0.5 7.71 0.39 1.5e-13 Diastolic blood pressure; LUSC cis rs7560272 0.695 rs780393 chr2:73701669 T/A cg20560298 chr2:73613845 ALMS1 0.45 7.14 0.36 5.99e-12 Schizophrenia; LUSC cis rs6840360 0.615 rs10021407 chr4:152465002 A/G cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs4666002 0.956 rs2384656 chr2:27832055 A/G cg27432699 chr2:27873401 GPN1 0.41 5.84 0.3 1.22e-8 Phospholipid levels (plasma); LUSC cis rs7119 0.931 rs59418918 chr15:77833110 A/C cg27398640 chr15:77910606 LINGO1 -0.32 -7.2 -0.37 4.01e-12 Type 2 diabetes; LUSC cis rs10752881 0.905 rs12132262 chr1:182989949 T/A ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.94e-22 Colorectal cancer; LUSC cis rs317689 0.690 rs570256 chr12:69662929 A/T cg11871910 chr12:69753446 YEATS4 0.45 5.9 0.31 9.14e-9 Response to diuretic therapy; LUSC cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg06627628 chr2:24431161 ITSN2 -0.61 -7.4 -0.38 1.09e-12 Lymphocyte counts; LUSC cis rs801193 0.613 rs2016325 chr7:66323500 T/C cg11764359 chr7:65958608 NA -0.44 -6.42 -0.33 4.66e-10 Aortic root size; LUSC cis rs11864453 0.826 rs2074627 chr16:72136769 C/T cg01557791 chr16:72042693 DHODH -0.51 -7.33 -0.37 1.74e-12 Fibrinogen levels; LUSC cis rs6547741 1.000 rs13026621 chr2:27807624 G/A cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 3.16e-39 Oral cavity cancer; LUSC cis rs11190604 0.945 rs7091356 chr10:102292268 G/C cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg21017887 chr14:105400489 NA 0.69 13.27 0.59 1.45e-32 Rheumatoid arthritis; LUSC cis rs9473147 0.516 rs10456570 chr6:47559451 A/G cg02130027 chr6:47444894 CD2AP 0.35 5.7 0.3 2.68e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs4343996 0.869 rs4544975 chr7:3385384 G/T cg21248987 chr7:3385318 SDK1 -0.41 -6.95 -0.36 1.91e-11 Motion sickness; LUSC cis rs13315871 1.000 rs9824965 chr3:58433505 T/A cg20936604 chr3:58311152 NA -0.72 -6.77 -0.35 5.83e-11 Cholesterol, total; LUSC cis rs1577917 0.958 rs13201730 chr6:86556647 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.77 -0.43 9.17e-17 Response to antipsychotic treatment; LUSC cis rs67601088 0.517 rs878903 chr7:29916772 A/T cg19413766 chr7:29689036 LOC646762 -0.43 -5.69 -0.3 2.81e-8 Pediatric bone mineral density (spine); LUSC cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg22906224 chr7:99728672 NA -0.6 -8.82 -0.43 6.47e-17 Coronary artery disease; LUSC cis rs61931739 0.635 rs1852225 chr12:33963004 C/T cg06521331 chr12:34319734 NA -0.41 -6.72 -0.35 7.9e-11 Morning vs. evening chronotype; LUSC cis rs7589342 0.862 rs12613864 chr2:106515869 G/A cg14210321 chr2:106509881 NCK2 -0.62 -9.58 -0.46 2.37e-19 Addiction; LUSC trans rs10511400 0.618 rs2035671 chr3:119875948 C/T cg02809009 chr19:50354510 PTOV1 -0.67 -6.11 -0.32 2.71e-9 Economic and political preferences (feminism/equality); LUSC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18404041 chr3:52824283 ITIH1 -0.52 -10.19 -0.49 2.09e-21 Bipolar disorder; LUSC cis rs7246657 0.943 rs7252346 chr19:37914682 G/A cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg13010199 chr12:38710504 ALG10B 0.67 10.33 0.49 6.8e-22 Bladder cancer; LUSC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg18876405 chr7:65276391 NA -0.56 -8.9 -0.44 3.55e-17 Aortic root size; LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs62400317 0.686 rs860741 chr6:44808435 G/A cg20913747 chr6:44695427 NA 0.43 6.88 0.35 2.99e-11 Total body bone mineral density; LUSC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg03709012 chr19:19516395 GATAD2A -0.77 -12.16 -0.55 2.1e-28 Tonsillectomy; LUSC cis rs6009527 1.000 rs4315635 chr22:49571530 G/T cg12746016 chr22:49560550 NA -0.41 -7.14 -0.36 5.95e-12 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs9837602 1.000 rs793472 chr3:99546110 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 5.78 0.3 1.74e-8 Breast cancer; LUSC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8.19e-17 Intelligence (multi-trait analysis); LUSC trans rs1459104 0.706 rs35228933 chr11:55027673 G/A cg15704280 chr7:45808275 SEPT13 0.72 5.97 0.31 5.93e-9 Body mass index; LUSC cis rs738322 0.935 rs75387 chr22:38572057 C/T cg17652424 chr22:38574118 PLA2G6 -0.3 -6.48 -0.33 3.36e-10 Cutaneous nevi; LUSC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.75 -0.35 6.36e-11 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08635118 chr7:6144369 USP42 -0.44 -6.55 -0.34 2.23e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2012796 0.743 rs61986598 chr14:81856865 G/A cg02996355 chr14:81879375 NA 0.53 7.78 0.39 9.42e-14 Night sleep phenotypes; LUSC cis rs4906332 1.000 rs4906327 chr14:103929039 C/T cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.78e-12 Coronary artery disease; LUSC cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.51 -7.31 -0.37 1.98e-12 Axial length; LUSC cis rs6940638 0.715 rs9348751 chr6:27067190 T/A cg09904177 chr6:26538194 HMGN4 -0.47 -6.78 -0.35 5.32e-11 Intelligence (multi-trait analysis); LUSC cis rs9309473 1.000 rs6753344 chr2:73653138 C/T cg20560298 chr2:73613845 ALMS1 0.44 6.23 0.32 1.44e-9 Metabolite levels; LUSC cis rs4713675 0.584 rs6938056 chr6:33669577 C/T cg14003231 chr6:33640908 ITPR3 0.31 5.96 0.31 6.53e-9 Plateletcrit; LUSC cis rs2456568 0.548 rs6483280 chr11:93661592 T/C cg17595323 chr11:93583763 C11orf90 -0.31 -5.66 -0.3 3.26e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.24e-8 Aortic root size; LUSC cis rs4423214 1.000 rs909217 chr11:71146577 G/A cg05163923 chr11:71159392 DHCR7 0.7 10.36 0.49 5.45e-22 Vitamin D levels; LUSC cis rs7843479 0.544 rs7839925 chr8:21792983 G/C cg17168535 chr8:21777572 XPO7 0.82 14.89 0.63 7.87e-39 Mean corpuscular volume; LUSC cis rs9921338 0.961 rs72773832 chr16:11413123 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.75 -0.35 6.64e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2011503 0.882 rs72999030 chr19:19364240 A/T cg11244672 chr19:19639970 YJEFN3 -0.54 -6.59 -0.34 1.76e-10 Bipolar disorder; LUSC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg09323728 chr8:95962352 TP53INP1 -0.42 -8.81 -0.43 7.18e-17 Type 2 diabetes; LUSC cis rs754466 0.580 rs1344966 chr10:79534527 T/C cg17075019 chr10:79541650 NA -0.78 -12.4 -0.56 2.72e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17767294 0.708 rs17693877 chr6:27707046 G/A cg08851530 chr6:28072375 NA 1.09 7.4 0.38 1.11e-12 Parkinson's disease; LUSC cis rs921968 0.643 rs2178019 chr2:219316303 G/A cg02176678 chr2:219576539 TTLL4 0.59 10.61 0.5 7.29e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.28 -0.32 1.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs2324229 0.927 rs1180199 chr6:83959023 T/C cg08257003 chr6:84140564 ME1 0.3 7.02 0.36 1.28e-11 Platelet-derived growth factor BB levels; LUSC cis rs75920871 0.748 rs7106662 chr11:116951385 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.4 -0.33 5.21e-10 Subjective well-being; LUSC cis rs13631 0.965 rs7853589 chr9:140003844 A/G cg14395844 chr9:139980277 LOC100289341;MAN1B1 -0.43 -6.77 -0.35 5.66e-11 Cerebrospinal fluid biomarker levels; LUSC cis rs2667011 0.512 rs62176720 chr2:160822201 G/T cg06573604 chr2:160760825 LY75 0.46 6.34 0.33 7.48e-10 Bilirubin levels; LUSC trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.61 -0.34 1.55e-10 Retinal vascular caliber; LUSC cis rs11030122 0.673 rs4910597 chr11:4094923 G/A cg18678763 chr11:4115507 RRM1 -0.47 -6.09 -0.32 3.1e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs12760731 0.720 rs11805590 chr1:178308911 A/G cg00404053 chr1:178313656 RASAL2 0.49 5.97 0.31 6.15e-9 Obesity-related traits; LUSC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg19318889 chr4:1322082 MAEA 0.57 9.55 0.46 2.87e-19 Longevity; LUSC cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg00677455 chr12:58241039 CTDSP2 0.59 8.57 0.42 3.9e-16 Multiple sclerosis; LUSC cis rs754466 1.000 rs12220902 chr10:79682918 C/T cg17075019 chr10:79541650 NA -0.64 -8.55 -0.42 4.46e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2839186 0.869 rs17176513 chr21:47682428 A/G cg13126279 chr21:47581558 C21orf56 -0.45 -6.81 -0.35 4.46e-11 Testicular germ cell tumor; LUSC cis rs6464929 0.956 rs11980538 chr7:148706163 T/C cg23583168 chr7:148888333 NA 0.47 5.99 0.31 5.41e-9 Pediatric bone mineral content (hip); LUSC cis rs2742234 0.541 rs11528481 chr10:43737767 C/A cg15436174 chr10:43711423 RASGEF1A 0.44 7.09 0.36 8.1e-12 Hirschsprung disease; LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg18404041 chr3:52824283 ITIH1 -0.57 -10.94 -0.51 5.27e-24 Bipolar disorder; LUSC trans rs57221529 0.766 rs17497684 chr5:558307 T/C cg08313168 chr12:7315531 NA 0.46 5.98 0.31 5.65e-9 Lung disease severity in cystic fibrosis; LUSC cis rs477692 0.905 rs555545 chr10:131411586 G/A cg11019008 chr10:131425282 MGMT 0.46 6.98 0.36 1.6e-11 Response to temozolomide; LUSC cis rs4664308 0.905 rs62177860 chr2:160960571 C/T cg03641300 chr2:160917029 PLA2R1 -0.69 -11.7 -0.54 1e-26 Idiopathic membranous nephropathy; LUSC trans rs7615952 0.576 rs2276726 chr3:125826287 C/G cg07211511 chr3:129823064 LOC729375 -0.78 -10.28 -0.49 9.94e-22 Blood pressure (smoking interaction); LUSC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg02423579 chr7:2872169 GNA12 -0.5 -7.26 -0.37 2.74e-12 Height; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 4.97e-14 Prudent dietary pattern; LUSC trans rs2898290 0.540 rs35005793 chr8:11450472 G/A cg06636001 chr8:8085503 FLJ10661 0.52 7.65 0.39 2.16e-13 Systolic blood pressure; LUSC cis rs7681440 0.935 rs3756059 chr4:90757272 G/A cg01966878 chr4:90757139 SNCA -0.37 -6.37 -0.33 6.18e-10 Dementia with Lewy bodies; LUSC cis rs35146811 0.695 rs1618851 chr7:99810643 T/G cg13334819 chr7:99746414 C7orf59 0.5 6.79 0.35 5.04e-11 Coronary artery disease; LUSC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -7.16 -0.36 5.23e-12 Hemoglobin concentration; LUSC cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg01579765 chr21:45077557 HSF2BP -0.46 -9.48 -0.46 5e-19 Mean corpuscular volume; LUSC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg18230493 chr5:56204884 C5orf35 0.57 9.09 0.45 9.08e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs6828523 0.698 rs59276855 chr4:175861215 T/C cg16870595 chr4:175839423 ADAM29 0.53 5.88 0.31 9.99e-9 Breast cancer; LUSC cis rs3845702 0.736 rs6433816 chr2:180809317 G/C cg01881094 chr2:180872142 CWC22 -1.06 -12.75 -0.57 1.28e-30 Schizophrenia; LUSC cis rs4343996 0.902 rs9969270 chr7:3368974 C/T cg21248987 chr7:3385318 SDK1 -0.39 -6.6 -0.34 1.65e-10 Motion sickness; LUSC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg07741184 chr6:167504864 NA 0.34 6.16 0.32 2.13e-9 Crohn's disease; LUSC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.84 11.46 0.53 7.28e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6430585 0.528 rs16832417 chr2:136744678 C/T cg07169764 chr2:136633963 MCM6 1.13 17.53 0.69 2.98e-49 Corneal structure; LUSC cis rs11864453 0.826 rs12448315 chr16:72147242 G/T cg16558253 chr16:72132732 DHX38 -0.42 -6.48 -0.33 3.28e-10 Fibrinogen levels; LUSC cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg25427524 chr10:38739819 LOC399744 -0.74 -13.92 -0.61 4.61e-35 Extrinsic epigenetic age acceleration; LUSC cis rs7927592 0.913 rs4084149 chr11:68288567 A/G cg20283391 chr11:68216788 NA -0.61 -8.55 -0.42 4.43e-16 Total body bone mineral density; LUSC cis rs394563 0.967 rs438852 chr6:149794533 C/T cg11245181 chr6:149772854 ZC3H12D 0.27 5.86 0.31 1.11e-8 Dupuytren's disease; LUSC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg22920501 chr2:26401640 FAM59B -0.73 -10.24 -0.49 1.38e-21 Gut microbiome composition (summer); LUSC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg10802521 chr3:52805072 NEK4 0.5 8.12 0.41 9.27e-15 Bipolar disorder; LUSC cis rs13242816 1.000 rs56180538 chr7:116079711 C/T cg16553024 chr7:116138462 CAV2 -0.53 -5.74 -0.3 2.18e-8 P wave duration; LUSC cis rs11779988 0.545 rs415840 chr8:17782134 C/T cg01800426 chr8:17659068 MTUS1 -0.5 -6.14 -0.32 2.34e-9 Breast cancer; LUSC cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg07520158 chr7:32535189 LSM5;AVL9 0.5 6.74 0.35 7.15e-11 Cognitive ability; LUSC cis rs6088580 0.524 rs7269596 chr20:33229063 T/C cg08999081 chr20:33150536 PIGU -0.4 -7.53 -0.38 4.82e-13 Glomerular filtration rate (creatinine); LUSC cis rs63406760 1 rs63406760 chr12:123742692 TG/T cg00376283 chr12:123451042 ABCB9 0.66 8.32 0.41 2.27e-15 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg26924012 chr15:45694286 SPATA5L1 -1.02 -16.19 -0.66 6.48e-44 Homoarginine levels; LUSC cis rs698813 0.774 rs2304769 chr2:44569474 G/A cg00619915 chr2:44497795 NA -0.39 -5.72 -0.3 2.4e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs9905704 0.628 rs2531735 chr17:56551139 A/G cg19466818 chr17:56409534 MIR142 0.37 6.7 0.34 8.86e-11 Testicular germ cell tumor; LUSC trans rs9944715 0.954 rs8086956 chr18:43773903 A/G cg01718231 chr17:29326311 RNF135 -0.48 -6.81 -0.35 4.62e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs1008375 0.800 rs35463363 chr4:17613423 G/T cg04450456 chr4:17643702 FAM184B 0.38 6.12 0.32 2.56e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs67072384 1.000 rs12271961 chr11:72453596 G/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg09035930 chr12:129282057 SLC15A4 0.66 13.28 0.59 1.37e-32 Systemic lupus erythematosus; LUSC cis rs1461503 0.932 rs7107575 chr11:122845406 C/T cg27398637 chr11:122830231 C11orf63 0.4 6.4 0.33 5.28e-10 Menarche (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25220625 chr8:21868116 NA 0.75 6.34 0.33 7.41e-10 Cognitive performance; LUSC cis rs9341835 0.772 rs9341841 chr6:64135010 G/A cg00787780 chr6:64151745 NA -0.34 -5.78 -0.3 1.72e-8 Schizophrenia; LUSC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg09699651 chr6:150184138 LRP11 0.46 7.35 0.37 1.58e-12 Testicular germ cell tumor; LUSC cis rs9937943 0.616 rs12923487 chr16:74644112 G/T cg01733217 chr16:74700730 RFWD3 0.63 6.5 0.34 2.84e-10 Neutrophil percentage of white cells; LUSC cis rs6076065 0.963 rs2424543 chr20:23389955 G/T cg11657817 chr20:23433608 CST11 0.43 8.75 0.43 1.04e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs523522 0.962 rs651627 chr12:121009198 C/T cg12219531 chr12:120966889 COQ5 0.65 9.21 0.45 3.62e-18 High light scatter reticulocyte count; LUSC cis rs1506636 0.854 rs6466879 chr7:123276197 G/A cg03229431 chr7:123269106 ASB15 -0.68 -11.3 -0.53 2.71e-25 Plateletcrit;Platelet count; LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.91 0.55 1.76e-27 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.32 0.56 5.14e-29 Prudent dietary pattern; LUSC cis rs3008870 0.755 rs2815362 chr1:67496803 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.32 0.56 5.35e-29 Lymphocyte percentage of white cells; LUSC cis rs11122272 0.766 rs2790870 chr1:231543823 A/G cg06096015 chr1:231504339 EGLN1 0.54 9.31 0.45 1.7e-18 Hemoglobin concentration; LUSC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg04719120 chr6:96025338 MANEA 0.47 5.85 0.3 1.16e-8 Behavioural disinhibition (generation interaction); LUSC cis rs7267979 1.000 rs2482941 chr20:25361216 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8050755 0.649 rs1800720 chr16:2105400 C/T cg04515572 chr16:2107413 TSC2 -0.72 -6.97 -0.36 1.7e-11 Major depressive disorder; LUSC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg13647721 chr17:30228624 UTP6 0.59 5.84 0.3 1.21e-8 Hip circumference adjusted for BMI; LUSC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg08975724 chr8:8085496 FLJ10661 -0.51 -7.3 -0.37 2.11e-12 Neuroticism; LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.45 0.46 6.01e-19 Bipolar disorder; LUSC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC trans rs12579753 1.000 rs12367791 chr12:82237278 C/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs7824557 0.628 rs11991153 chr8:11203107 A/T cg21293242 chr8:11204541 TDH 0.32 6.01 0.31 4.86e-9 Retinal vascular caliber; LUSC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg27494647 chr7:150038898 RARRES2 0.54 7.85 0.39 5.85e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg11764359 chr7:65958608 NA 0.64 9.69 0.47 9.82e-20 Aortic root size; LUSC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg16049864 chr8:95962084 TP53INP1 -0.61 -11.14 -0.52 1.01e-24 Type 2 diabetes; LUSC cis rs6599077 0.616 rs9878321 chr3:40174858 A/G cg13683864 chr3:40499215 RPL14 -0.51 -6.53 -0.34 2.52e-10 Sleep-related phenotypes; LUSC cis rs55871839 0.708 rs10112089 chr8:59813429 C/T cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs4631830 0.832 rs1585378 chr10:51523213 A/T cg16070123 chr10:51489643 NA -0.52 -8.4 -0.42 1.26e-15 Prostate-specific antigen levels; LUSC cis rs11166629 1.000 rs3739423 chr8:135614705 A/G cg21672855 chr8:135614777 ZFAT 0.38 5.99 0.31 5.31e-9 Smoking quantity; LUSC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg06808227 chr14:105710500 BRF1 -0.65 -10.01 -0.48 8.32e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg26408565 chr15:76604113 ETFA -0.48 -7.64 -0.39 2.36e-13 Blood metabolite levels; LUSC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg14893161 chr1:205819251 PM20D1 -0.44 -6.11 -0.32 2.75e-9 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs6969780 1.000 rs1801085 chr7:27168590 A/G cg26364809 chr7:27145159 NA -0.56 -5.73 -0.3 2.28e-8 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs11190604 1.000 rs10786596 chr10:102282126 C/A cg07080220 chr10:102295463 HIF1AN 0.67 9.33 0.45 1.54e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs2742417 1.000 rs2673058 chr3:45735618 A/C cg09608765 chr3:45636137 LIMD1 -0.37 -7.29 -0.37 2.23e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs950027 0.620 rs1145084 chr15:45675440 G/A cg14582100 chr15:45693742 SPATA5L1 0.46 8.73 0.43 1.2e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs2880765 0.835 rs1872074 chr15:86033184 T/G cg13263323 chr15:86062960 AKAP13 -0.35 -5.72 -0.3 2.38e-8 Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26439071 chr12:124155620 TCTN2 0.75 5.96 0.31 6.49e-9 Cognitive performance; LUSC cis rs9283706 0.950 rs10053810 chr5:66281898 C/G cg11590213 chr5:66331682 MAST4 -0.41 -6.18 -0.32 1.89e-9 Coronary artery disease; LUSC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg16235748 chr6:149772707 ZC3H12D 0.28 5.75 0.3 2.05e-8 Dupuytren's disease; LUSC cis rs1564271 0.528 rs2209350 chr10:26987779 A/G cg13837822 chr10:26931731 LOC731789 0.45 9.91 0.48 1.83e-20 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs8077577 0.895 rs11655588 chr17:18107451 C/T cg16794390 chr17:18148240 FLII -0.44 -6.2 -0.32 1.71e-9 Obesity-related traits; LUSC trans rs61931739 0.517 rs34760282 chr12:34153711 G/T cg26384229 chr12:38710491 ALG10B 0.73 11.89 0.55 2.03e-27 Morning vs. evening chronotype; LUSC cis rs262150 0.501 rs2730206 chr7:158815173 G/C cg09640425 chr7:158790006 NA -0.52 -8.19 -0.41 5.5e-15 Facial morphology (factor 20); LUSC trans rs9393777 0.920 rs13207689 chr6:27369704 C/G cg06606381 chr12:133084897 FBRSL1 -1.01 -8.96 -0.44 2.39e-17 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3762318 0.525 rs4655520 chr1:67591660 G/A cg02640540 chr1:67518911 SLC35D1 0.61 6.3 0.33 9.32e-10 Leprosy; LUSC cis rs13385 0.769 rs17286613 chr5:139581205 T/G cg26211634 chr5:139558579 C5orf32 0.44 6.31 0.33 8.82e-10 Atrial fibrillation; LUSC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg04369109 chr6:150039330 LATS1 -0.58 -8.61 -0.43 2.83e-16 Lung cancer; LUSC cis rs9929218 0.911 rs4783685 chr16:68834107 C/T cg02972257 chr16:68554789 NA 0.42 5.7 0.3 2.68e-8 Colorectal cancer; LUSC cis rs734999 0.505 rs4073285 chr1:2539796 C/T cg18854424 chr1:2615690 NA 0.5 10.04 0.48 6.64e-21 Ulcerative colitis; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg10862848 chr6:42927986 GNMT 0.26 5.95 0.31 6.68e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg07148914 chr20:33460835 GGT7 0.54 8.43 0.42 1.03e-15 Height; LUSC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.27 0.59 1.41e-32 Hip circumference adjusted for BMI; LUSC trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg15704280 chr7:45808275 SEPT13 0.86 11.38 0.53 1.4e-25 Coronary artery disease; LUSC trans rs2228479 0.850 rs17232910 chr16:89839766 G/C cg24644049 chr4:85504048 CDS1 0.86 7.56 0.38 3.83e-13 Skin colour saturation; LUSC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg18135555 chr8:22132992 PIWIL2 0.4 7.91 0.4 3.77e-14 Hypertriglyceridemia; LUSC cis rs2637266 0.745 rs2579733 chr10:78441896 C/T cg18941641 chr10:78392320 NA -0.33 -5.79 -0.3 1.61e-8 Pulmonary function; LUSC trans rs8072100 0.967 rs4793842 chr17:45671506 G/A cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.18e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg22907277 chr7:1156413 C7orf50 0.48 7.13 0.36 6.37e-12 Longevity;Endometriosis; LUSC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg09796270 chr17:17721594 SREBF1 -0.4 -7.0 -0.36 1.37e-11 Total body bone mineral density; LUSC cis rs17685 0.671 rs10274404 chr7:75706634 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.64 -0.39 2.34e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg24675056 chr1:15929824 NA 0.48 8.24 0.41 3.92e-15 Systolic blood pressure; LUSC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg13798912 chr7:905769 UNC84A -0.56 -5.77 -0.3 1.85e-8 Cerebrospinal P-tau181p levels; LUSC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg00376283 chr12:123451042 ABCB9 0.69 8.71 0.43 1.4e-16 Neutrophil percentage of white cells; LUSC cis rs2953174 0.786 rs2953146 chr2:241515252 A/G cg07929629 chr2:241523174 NA -0.5 -7.94 -0.4 3.2e-14 Bipolar disorder; LUSC cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg05283184 chr6:79620031 NA -0.57 -12.11 -0.55 3.08e-28 Intelligence (multi-trait analysis); LUSC trans rs9291683 0.620 rs7699512 chr4:10125808 C/T cg26043149 chr18:55253948 FECH -0.53 -7.64 -0.39 2.26e-13 Bone mineral density; LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg18404041 chr3:52824283 ITIH1 -0.57 -11.04 -0.52 2.32e-24 Bipolar disorder; LUSC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg25036284 chr2:26402008 FAM59B 0.71 10.06 0.48 5.58e-21 Gut microbiome composition (summer); LUSC cis rs2274273 0.934 rs8021940 chr14:55719715 G/A cg04306507 chr14:55594613 LGALS3 0.57 13.47 0.59 2.39e-33 Protein biomarker; LUSC cis rs7267979 0.714 rs2474763 chr20:25241295 A/G cg08601574 chr20:25228251 PYGB 0.48 7.42 0.38 9.92e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg19812747 chr11:111475976 SIK2 -0.56 -8.11 -0.41 9.51e-15 Primary sclerosing cholangitis; LUSC cis rs1775715 0.870 rs1775737 chr10:32256871 T/C cg26784012 chr10:32216390 ARHGAP12 0.41 6.64 0.34 1.29e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7715806 0.500 rs17649362 chr5:75008958 C/T cg19683494 chr5:74908142 NA 0.58 7.75 0.39 1.11e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9486719 1.000 rs12190397 chr6:97036465 G/A cg06623918 chr6:96969491 KIAA0776 -0.84 -10.4 -0.49 3.86e-22 Migraine;Coronary artery disease; LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs3741151 0.686 rs12290701 chr11:73271988 T/C cg17517138 chr11:73019481 ARHGEF17 0.82 7.65 0.39 2.15e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9287719 0.745 rs4997810 chr2:10755540 T/A cg03983476 chr2:10830698 NOL10 -0.38 -5.77 -0.3 1.83e-8 Prostate cancer; LUSC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs10876993 0.928 rs2640637 chr12:58077586 G/A cg15848620 chr12:58087721 OS9 -0.57 -8.04 -0.4 1.56e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg21862992 chr11:68658383 NA 0.49 7.74 0.39 1.23e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg21535247 chr6:8435926 SLC35B3 0.57 9.02 0.44 1.5e-17 Motion sickness; LUSC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC trans rs853679 0.517 rs55747925 chr6:28044337 T/C cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs9356171 0.572 rs11756250 chr6:164325686 A/G cg25752492 chr6:164341247 NA -0.39 -6.68 -0.34 9.82e-11 Diisocyanate-induced asthma; LUSC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg23887609 chr12:130822674 PIWIL1 0.49 7.34 0.37 1.64e-12 Menopause (age at onset); LUSC cis rs56283067 0.887 rs9463042 chr6:44770527 T/C cg18551225 chr6:44695536 NA -0.47 -7.67 -0.39 1.9e-13 Total body bone mineral density; LUSC cis rs9811920 0.535 rs792837 chr3:99477182 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.31 -5.85 -0.31 1.15e-8 Axial length; LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs2742234 0.590 rs1254962 chr10:43696992 G/A cg15436174 chr10:43711423 RASGEF1A 0.43 7.01 0.36 1.32e-11 Hirschsprung disease; LUSC cis rs6500602 0.893 rs4785962 chr16:4484328 A/G cg08645402 chr16:4508243 NA 0.51 8.44 0.42 9.54e-16 Schizophrenia; LUSC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg06671660 chr6:41068741 NFYA;LOC221442 0.39 5.78 0.3 1.7e-8 Alzheimer's disease (late onset); LUSC cis rs17401966 0.838 rs2105212 chr1:10281012 T/C cg19773385 chr1:10388646 KIF1B -0.53 -9.15 -0.45 5.94e-18 Hepatocellular carcinoma; LUSC cis rs2282802 0.685 rs6870103 chr5:139692515 G/T cg26211634 chr5:139558579 C5orf32 -0.42 -8.08 -0.4 1.22e-14 Intelligence (multi-trait analysis); LUSC cis rs7223966 1.000 rs1877316 chr17:61766880 C/A cg00945038 chr17:61921165 SMARCD2 0.39 5.8 0.3 1.5e-8 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs10435719 0.834 rs11250176 chr8:11792816 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.2e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9790314 0.521 rs2122527 chr3:161091636 G/A cg03342759 chr3:160939853 NMD3 -0.42 -6.18 -0.32 1.88e-9 Morning vs. evening chronotype; LUSC cis rs3820068 0.705 rs4646031 chr1:15834648 A/G cg17385448 chr1:15911702 AGMAT 0.39 6.13 0.32 2.51e-9 Systolic blood pressure; LUSC cis rs12681288 0.676 rs4565481 chr8:1001944 C/T cg15309053 chr8:964076 NA 0.38 7.84 0.39 5.98e-14 Schizophrenia; LUSC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg12463550 chr7:65579703 CRCP -0.43 -6.2 -0.32 1.7e-9 Aortic root size; LUSC cis rs2235649 0.843 rs9932890 chr16:1847868 G/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 0.44 5.89 0.31 9.52e-9 Blood metabolite levels; LUSC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg13206674 chr6:150067644 NUP43 -0.57 -8.89 -0.44 3.79e-17 Lung cancer; LUSC cis rs6906287 0.647 rs67832971 chr6:118832205 C/T cg21191810 chr6:118973309 C6orf204 0.32 5.83 0.3 1.27e-8 Electrocardiographic conduction measures; LUSC cis rs17270561 0.583 rs9393661 chr6:25739080 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC cis rs8060686 0.920 rs55661503 chr16:67836552 T/A cg27539214 chr16:67997921 SLC12A4 -0.46 -5.93 -0.31 7.38e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs921968 0.643 rs535830 chr2:219372233 C/G cg02176678 chr2:219576539 TTLL4 0.6 10.67 0.5 4.48e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg04414720 chr1:150670196 GOLPH3L 0.5 7.94 0.4 3.04e-14 Melanoma; LUSC cis rs10782582 0.609 rs1001160 chr1:76358591 A/C cg10523679 chr1:76189770 ACADM -0.42 -6.28 -0.32 1.08e-9 Daytime sleep phenotypes; LUSC cis rs6500395 1.000 rs12597928 chr16:48714366 G/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs71403859 0.803 rs17282500 chr16:71633653 C/A cg08717414 chr16:71523259 ZNF19 -0.72 -7.94 -0.4 3.11e-14 Post bronchodilator FEV1; LUSC cis rs2730245 0.510 rs2788474 chr7:158649005 T/C cg01943577 chr7:158741284 NA -0.42 -6.06 -0.31 3.76e-9 Height; LUSC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg18850127 chr7:39170497 POU6F2 0.67 11.0 0.52 3.13e-24 IgG glycosylation; LUSC cis rs2658782 1.000 rs2658782 chr11:93166731 T/G cg15737290 chr11:93063684 CCDC67 0.68 8.42 0.42 1.15e-15 Pulmonary function decline; LUSC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs3824867 0.920 rs7948705 chr11:47447955 C/G cg20307385 chr11:47447363 PSMC3 -0.64 -9.52 -0.46 3.67e-19 Mean corpuscular hemoglobin; LUSC cis rs2387326 0.717 rs10829334 chr10:129943402 C/T cg16087940 chr10:129947807 NA -0.39 -5.81 -0.3 1.48e-8 Select biomarker traits; LUSC cis rs9303401 0.659 rs17822837 chr17:56737838 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.69 0.57 2.2e-30 Cognitive test performance; LUSC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg14440974 chr22:39074834 NA -0.36 -5.8 -0.3 1.55e-8 Menopause (age at onset); LUSC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg22875332 chr1:76189707 ACADM -0.77 -10.32 -0.49 7.64e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg05283184 chr6:79620031 NA -0.54 -11.17 -0.52 7.97e-25 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.620 rs61927756 chr12:33709931 A/G cg26384229 chr12:38710491 ALG10B -0.42 -6.13 -0.32 2.44e-9 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg08470875 chr2:26401718 FAM59B -0.64 -8.78 -0.43 8.42e-17 Gut microbiome composition (summer); LUSC cis rs6494488 0.500 rs72744710 chr15:65014078 G/A cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.69 0.3 2.79e-8 Personality dimensions; LUSC cis rs2227564 0.729 rs2675675 chr10:75649048 G/A cg23231163 chr10:75533350 FUT11 -0.43 -5.82 -0.3 1.37e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7814319 0.933 rs13261747 chr8:97238769 A/G cg20787634 chr8:97240163 UQCRB -0.35 -6.1 -0.32 2.87e-9 Lung function (FVC); LUSC cis rs1568889 0.938 rs7128045 chr11:28190180 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 9.03 0.44 1.36e-17 Bipolar disorder; LUSC cis rs1865760 0.927 rs6915834 chr6:25935427 A/C cg17691542 chr6:26056736 HIST1H1C 0.47 7.0 0.36 1.43e-11 Height; LUSC trans rs73019876 0.805 rs2522106 chr19:22140621 T/A cg16204205 chr18:19753432 GATA6 0.31 5.94 0.31 7.01e-9 Testicular germ cell tumor; LUSC cis rs4478037 0.822 rs9865342 chr3:33118631 G/A cg19404215 chr3:33155277 CRTAP 0.99 9.82 0.47 3.79e-20 Major depressive disorder; LUSC cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg00012203 chr2:219082015 ARPC2 0.71 11.8 0.54 4.15e-27 Colorectal cancer; LUSC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg22875332 chr1:76189707 ACADM 0.76 10.23 0.49 1.48e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7712401 0.791 rs154507 chr5:122200907 C/G cg19077854 chr5:122220652 SNX24 -0.35 -8.13 -0.41 8.32e-15 Mean platelet volume; LUSC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.42 5.83 0.3 1.29e-8 Height; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg08866814 chr16:89351500 ANKRD11 -0.67 -6.28 -0.32 1.03e-9 Myocardial infarction; LUSC cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.35 -5.67 -0.3 3.1e-8 Body mass index; LUSC trans rs9291683 0.588 rs13121211 chr4:9999539 A/G cg26043149 chr18:55253948 FECH 0.5 7.31 0.37 1.96e-12 Bone mineral density; LUSC trans rs459571 0.606 rs457420 chr9:136909261 A/G cg10765909 chr12:53715428 AAAS 0.44 6.75 0.35 6.44e-11 Platelet distribution width; LUSC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg16423285 chr20:60520624 NA -0.47 -5.84 -0.3 1.22e-8 Body mass index; LUSC cis rs2777491 0.874 rs28716108 chr15:41655523 G/C cg18705301 chr15:41695430 NDUFAF1 -0.79 -15.55 -0.65 2.16e-41 Ulcerative colitis; LUSC cis rs3125734 0.633 rs10761616 chr10:64009076 G/A cg19640130 chr10:64028056 RTKN2 -0.4 -7.1 -0.36 7.48e-12 Rheumatoid arthritis; LUSC cis rs11247915 0.540 rs11582416 chr1:26677721 A/G cg04990556 chr1:26633338 UBXN11 0.47 6.36 0.33 6.56e-10 Obesity-related traits; LUSC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC trans rs208520 0.661 rs7740835 chr6:66865548 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.7 -0.67 5.93e-46 Exhaled nitric oxide output; LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -8.16 -0.41 6.77e-15 Glomerular filtration rate (creatinine); LUSC cis rs5771225 0.505 rs2341111 chr22:50690322 G/C cg16473166 chr22:50639996 SELO 0.6 7.98 0.4 2.45e-14 Late-onset Alzheimer's disease; LUSC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.57 -0.38 3.65e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg12292205 chr6:26970375 C6orf41 0.71 12.15 0.55 2.25e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs6489882 0.867 rs7958379 chr12:113363284 A/G cg20102336 chr12:113376681 OAS3 -0.42 -5.92 -0.31 7.96e-9 Chronic lymphocytic leukemia; LUSC cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg22782873 chr19:19639568 YJEFN3 0.5 6.11 0.32 2.84e-9 Bipolar disorder; LUSC cis rs12422267 0.536 rs12303484 chr12:132609558 G/A cg09764611 chr12:132620959 NA -0.58 -8.66 -0.43 2.06e-16 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs80130819 0.636 rs4760623 chr12:48619256 A/C cg24011408 chr12:48396354 COL2A1 0.47 5.88 0.31 1.01e-8 Prostate cancer; LUSC cis rs909341 0.868 rs1291206 chr20:62329169 G/A cg09650180 chr20:62225654 GMEB2 -0.46 -6.03 -0.31 4.39e-9 Atopic dermatitis; LUSC cis rs6733011 0.519 rs12990579 chr2:99457447 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.01 -0.31 4.8e-9 Bipolar disorder; LUSC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg08270630 chr22:50330655 NA -0.41 -6.16 -0.32 2.14e-9 Schizophrenia; LUSC trans rs60843830 0.661 rs11674477 chr2:105822 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.52 8.02 0.4 1.8e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg04865166 chr7:105162814 PUS7 0.53 5.87 0.31 1.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs1580019 0.961 rs2392056 chr7:32498953 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.86 0.54 2.63e-27 Cognitive ability; LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.89 0.55 1.95e-27 Prudent dietary pattern; LUSC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg00343986 chr7:65444356 GUSB 0.47 7.12 0.36 6.71e-12 Aortic root size; LUSC trans rs1728785 0.901 rs698711 chr16:68561955 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.57 0.38 3.58e-13 Ulcerative colitis; LUSC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg02018176 chr4:1364513 KIAA1530 0.47 7.65 0.39 2.19e-13 Obesity-related traits; LUSC cis rs6580649 0.831 rs1635528 chr12:48395900 C/T cg24011408 chr12:48396354 COL2A1 0.54 7.11 0.36 7.25e-12 Lung cancer; LUSC cis rs9311676 0.656 rs11712139 chr3:58384775 C/T cg13750441 chr3:58318267 PXK 0.34 6.57 0.34 1.9e-10 Systemic lupus erythematosus; LUSC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg11062466 chr8:58055876 NA 0.51 6.44 0.33 4.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs7589342 0.791 rs4438504 chr2:106461035 A/C cg16077055 chr2:106428750 NCK2 0.33 6.17 0.32 1.92e-9 Addiction; LUSC cis rs7829975 0.811 rs7011229 chr8:8543324 T/C cg15556689 chr8:8085844 FLJ10661 -0.6 -9.51 -0.46 3.9e-19 Mood instability; LUSC cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg23173402 chr1:227635558 NA 0.58 7.0 0.36 1.45e-11 Major depressive disorder; LUSC cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.7 -11.13 -0.52 1.08e-24 Colorectal cancer; LUSC cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg24531977 chr5:56204891 C5orf35 -0.96 -14.61 -0.62 1.02e-37 Initial pursuit acceleration; LUSC trans rs1814175 0.935 rs7925863 chr11:49615802 C/A cg03929089 chr4:120376271 NA -0.99 -17.41 -0.69 9.5e-49 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25125898 chr5:5422196 KIAA0947 -0.45 -6.75 -0.35 6.39e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg00316803 chr15:76480434 C15orf27 -0.4 -6.8 -0.35 4.95e-11 Blood metabolite levels; LUSC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.67 -0.39 1.85e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs11971779 0.523 rs10234578 chr7:139037988 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs9560113 1.000 rs4773379 chr13:112176088 G/C cg14154082 chr13:112174009 NA 0.4 8.2 0.41 5.06e-15 Menarche (age at onset); LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs1572438 1.000 rs873560 chr6:875559 A/G cg13447295 chr6:887704 NA -0.39 -5.79 -0.3 1.61e-8 Aging; LUSC trans rs629535 0.773 rs569064 chr8:70065967 A/G cg21567404 chr3:27674614 NA 0.97 15.48 0.65 3.82e-41 Dupuytren's disease; LUSC trans rs1997103 1.000 rs10278894 chr7:55404748 A/G cg20935933 chr6:143382018 AIG1 0.5 7.27 0.37 2.61e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg01028140 chr2:1542097 TPO -0.37 -6.07 -0.32 3.51e-9 IgG glycosylation; LUSC cis rs939574 1.000 rs56927225 chr2:220100922 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.09 8.72 0.43 1.31e-16 Platelet distribution width; LUSC cis rs722599 1.000 rs722599 chr14:75327443 T/C cg08847533 chr14:75593920 NEK9 -0.41 -5.96 -0.31 6.38e-9 IgG glycosylation; LUSC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg13319975 chr6:146136371 FBXO30 0.5 7.52 0.38 5.18e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs3803170 0.513 rs4766573 chr12:111830809 C/A cg10833066 chr12:111807467 FAM109A 0.38 7.17 0.37 4.88e-12 Mean corpuscular hemoglobin; LUSC trans rs8073060 0.559 rs72829925 chr17:34049778 C/A cg19694781 chr19:47549865 TMEM160 1.14 18.04 0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs8017423 0.967 rs4900033 chr14:90701963 C/A cg04374321 chr14:90722782 PSMC1 0.73 11.62 0.54 1.87e-26 Mortality in heart failure; LUSC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg05802129 chr4:122689817 NA -0.52 -8.78 -0.43 8.4e-17 Type 2 diabetes; LUSC trans rs800082 1.000 rs28847402 chr3:144316893 C/G cg24215973 chr2:240111563 HDAC4 -0.46 -6.98 -0.36 1.62e-11 Smoking behavior; LUSC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg19774624 chr17:42201019 HDAC5 0.71 10.48 0.5 2.07e-22 Total body bone mineral density; LUSC cis rs11650494 0.908 rs11650087 chr17:47362923 T/A cg08112188 chr17:47440006 ZNF652 1.22 10.33 0.49 6.95e-22 Prostate cancer; LUSC cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.49 -6.79 -0.35 5.21e-11 Cognitive ability; LUSC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg21951975 chr1:209979733 IRF6 0.57 8.52 0.42 5.74e-16 Cleft lip with or without cleft palate; LUSC cis rs877282 0.898 rs11253343 chr10:765117 C/T cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC trans rs225245 0.791 rs720774 chr17:34017453 T/G cg19694781 chr19:47549865 TMEM160 -0.41 -6.39 -0.33 5.58e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg03929089 chr4:120376271 NA -0.69 -7.74 -0.39 1.19e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg07148914 chr20:33460835 GGT7 0.54 8.27 0.41 3.18e-15 Height; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg19747945 chr6:42946146 PEX6 -0.35 -5.67 -0.3 3.11e-8 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs561341 0.783 rs512698 chr17:30292507 G/T cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs4964805 0.580 rs10861097 chr12:104170474 C/T cg02344784 chr12:104178138 NT5DC3 0.37 5.97 0.31 6.08e-9 Attention deficit hyperactivity disorder; LUSC cis rs7267979 0.844 rs2474780 chr20:25285835 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.77 16.24 0.66 4.1e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3741151 0.656 rs56884659 chr11:73252947 C/G cg17517138 chr11:73019481 ARHGEF17 0.97 8.12 0.41 8.78e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs12458462 0.509 rs3786241 chr18:77494328 A/C cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.58 -8.65 -0.43 2.2e-16 Monocyte count; LUSC cis rs7829975 0.606 rs6422352 chr8:8794193 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.88 -0.35 2.88e-11 Mood instability; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22934568 chr3:48884614 PRKAR2A -0.5 -6.23 -0.32 1.42e-9 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg02569458 chr12:86230093 RASSF9 0.58 9.78 0.47 4.91e-20 Major depressive disorder; LUSC cis rs12410462 0.581 rs4329477 chr1:227552494 A/G cg10327440 chr1:227177885 CDC42BPA 0.61 6.38 0.33 5.98e-10 Major depressive disorder; LUSC cis rs877282 0.947 rs7904978 chr10:768078 C/T cg17470449 chr10:769945 NA 0.55 7.78 0.39 9.07e-14 Uric acid levels; LUSC trans rs453301 0.522 rs2929455 chr8:9083433 A/T cg21775007 chr8:11205619 TDH -0.43 -6.09 -0.32 3.14e-9 Joint mobility (Beighton score); LUSC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg27165867 chr14:105738592 BRF1 0.53 7.67 0.39 1.86e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs8114671 0.586 rs734111 chr20:33533736 A/C cg08999081 chr20:33150536 PIGU 0.32 5.66 0.3 3.24e-8 Height; LUSC cis rs12541635 0.639 rs6415444 chr8:107043797 G/A cg10147462 chr8:107024639 NA 0.66 13.76 0.6 1.86e-34 Age of smoking initiation; LUSC trans rs7944735 0.517 rs11039538 chr11:48154990 A/T cg15704280 chr7:45808275 SEPT13 0.72 6.58 0.34 1.86e-10 Intraocular pressure; LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg25767906 chr1:53392781 SCP2 0.48 8.69 0.43 1.67e-16 Monocyte count; LUSC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg18827107 chr12:86230957 RASSF9 -0.5 -7.29 -0.37 2.3e-12 Major depressive disorder; LUSC cis rs2692947 0.864 rs2579518 chr2:96675259 G/A cg23100626 chr2:96804247 ASTL 0.26 6.58 0.34 1.78e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.6 -8.06 -0.4 1.38e-14 Systemic lupus erythematosus; LUSC cis rs12291225 0.585 rs12270374 chr11:14375079 T/C cg05501817 chr11:14380813 RRAS2 -0.56 -9.17 -0.45 4.98e-18 Sense of smell; LUSC cis rs11264799 0.765 rs12144103 chr1:157620499 A/G cg18268488 chr1:157545234 FCRL4 0.33 5.81 0.3 1.49e-8 IgA nephropathy; LUSC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg27170947 chr2:26402098 FAM59B -0.63 -9.4 -0.46 9.08e-19 Gut microbiome composition (summer); LUSC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg03806693 chr22:41940476 POLR3H 1.01 13.86 0.6 8.07e-35 Crohn's disease;Inflammatory bowel disease; LUSC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.59 -0.54 2.5e-26 Schizophrenia; LUSC cis rs4964805 0.773 rs35746861 chr12:104225284 C/T cg02344784 chr12:104178138 NT5DC3 0.42 6.51 0.34 2.82e-10 Attention deficit hyperactivity disorder; LUSC cis rs2067615 0.524 rs10778504 chr12:107120424 C/T cg15890332 chr12:107067104 RFX4 0.34 6.05 0.31 3.78e-9 Heart rate; LUSC cis rs9549260 0.709 rs4581585 chr13:41203905 C/T cg21288729 chr13:41239152 FOXO1 0.61 9.59 0.46 2.13e-19 Red blood cell count; LUSC cis rs10782582 0.564 rs17647711 chr1:76241710 C/G cg10523679 chr1:76189770 ACADM -0.44 -6.26 -0.32 1.16e-9 Daytime sleep phenotypes; LUSC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.58 -0.38 3.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2979489 0.891 rs7822839 chr8:30354453 A/G cg26383811 chr8:30366931 RBPMS 0.48 7.8 0.39 7.76e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs4268898 1.000 rs6707781 chr2:24441883 T/G cg06627628 chr2:24431161 ITSN2 0.61 9.09 0.45 9.2e-18 Asthma; LUSC cis rs7937682 0.924 rs495460 chr11:111504777 G/A cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs2204008 0.527 rs1315367 chr12:38177487 G/T cg26384229 chr12:38710491 ALG10B -0.67 -10.46 -0.5 2.39e-22 Bladder cancer; LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg09177884 chr7:1199841 ZFAND2A -0.58 -8.12 -0.41 9.03e-15 Longevity;Endometriosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24123563 chr14:77924517 C14orf133;AHSA1 0.44 6.1 0.32 2.93e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.52 -7.93 -0.4 3.39e-14 Schizophrenia; LUSC cis rs3135071 1.000 rs3135071 chr4:2406321 C/T cg01601518 chr4:2404284 ZFYVE28 0.47 5.77 0.3 1.79e-8 Influenza A (H1N1) severity; LUSC trans rs12439619 0.508 rs11856561 chr15:82453756 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.46 -7.16 -0.36 5.1e-12 Intelligence (multi-trait analysis); LUSC trans rs783147 0.500 rs4252130 chr6:161153080 A/C cg00639886 chr12:54943102 PDE1B -0.46 -6.46 -0.33 3.69e-10 Lp (a) levels; LUSC cis rs7246967 0.673 rs8103012 chr19:22879285 C/T cg23217946 chr19:22817039 ZNF492 0.39 5.64 0.3 3.56e-8 Bronchopulmonary dysplasia; LUSC cis rs2820315 1.000 rs8024 chr1:201845575 C/A cg10061532 chr1:201886748 LMOD1 0.26 5.87 0.31 1.05e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg25019033 chr10:957182 NA -0.53 -6.84 -0.35 3.74e-11 Eosinophil percentage of granulocytes; LUSC cis rs9902453 0.765 rs2729447 chr17:28099002 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.67 -0.54 1.26e-26 Coffee consumption (cups per day); LUSC cis rs983392 0.709 rs11603507 chr11:59982470 T/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.92 -0.31 8.12e-9 Alzheimer's disease (late onset); LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs6977660 0.943 rs10225293 chr7:19840636 C/T cg05791153 chr7:19748676 TWISTNB -0.55 -6.22 -0.32 1.47e-9 Thyroid stimulating hormone; LUSC cis rs7089973 0.604 rs7914792 chr10:116591391 T/C cg25233709 chr10:116636983 FAM160B1 0.37 6.59 0.34 1.69e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg00409905 chr10:38381863 ZNF37A -0.38 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC trans rs877282 0.786 rs11253392 chr10:788768 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs5758511 0.680 rs1107553 chr22:42667473 A/G cg12850546 chr22:42539477 CYP2D7P1 -0.47 -5.83 -0.3 1.29e-8 Birth weight; LUSC cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -7.76 -0.39 1.01e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.73 0.39 1.26e-13 Bipolar disorder; LUSC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg07741184 chr6:167504864 NA 0.43 7.63 0.39 2.43e-13 Crohn's disease; LUSC cis rs2732480 0.500 rs12828309 chr12:48641160 C/T cg04545296 chr12:48745243 ZNF641 0.32 5.88 0.31 1.02e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC cis rs4499344 0.730 rs380320 chr19:33105904 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.85 12.86 0.58 4.89e-31 Mean platelet volume; LUSC cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg19875535 chr5:140030758 IK 0.47 7.68 0.39 1.78e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg19717773 chr7:2847554 GNA12 -0.4 -6.35 -0.33 6.98e-10 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03982507 chr18:44496911 PIAS2 -0.47 -6.25 -0.32 1.26e-9 Hepatitis; LUSC cis rs4268898 0.560 rs2384007 chr2:24514841 A/G cg06627628 chr2:24431161 ITSN2 -0.86 -12.45 -0.56 1.73e-29 Asthma; LUSC cis rs734999 0.967 rs10797434 chr1:2511280 C/T cg18854424 chr1:2615690 NA 0.46 9.54 0.46 3.1400000000000002e-19 Ulcerative colitis; LUSC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg02038168 chr22:39784481 NA -0.43 -6.47 -0.33 3.47e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs13720 0.722 rs191490 chr20:57576180 A/G cg23907860 chr20:57583709 CTSZ -0.46 -6.03 -0.31 4.27e-9 Platelet distribution width; LUSC cis rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05901451 chr6:126070800 HEY2 -0.71 -11.18 -0.52 7.32e-25 Migraine; LUSC cis rs9905704 0.681 rs4793949 chr17:56571950 C/T cg19466818 chr17:56409534 MIR142 -0.36 -6.93 -0.35 2.2e-11 Testicular germ cell tumor; LUSC cis rs208520 0.690 rs12198297 chr6:66714665 G/A cg07460842 chr6:66804631 NA 1.1 17.21 0.69 5.83e-48 Exhaled nitric oxide output; LUSC cis rs2540226 0.816 rs4670958 chr2:39980724 A/G cg23576258 chr2:39999331 THUMPD2 -0.37 -6.28 -0.33 1.03e-9 Personality dimensions; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg09177884 chr7:1199841 ZFAND2A -0.44 -5.95 -0.31 6.91e-9 Longevity;Endometriosis; LUSC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg10523679 chr1:76189770 ACADM -0.89 -14.27 -0.62 2.11e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7903847 0.596 rs10786340 chr10:99156563 G/C cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg06494592 chr3:125709126 NA -0.52 -6.01 -0.31 4.85e-9 Blood pressure (smoking interaction); LUSC cis rs3015497 0.631 rs17718908 chr14:51005213 A/G cg26011998 chr14:51135199 SAV1 0.46 5.7 0.3 2.7e-8 Mean platelet volume; LUSC cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg01579765 chr21:45077557 HSF2BP -0.55 -11.13 -0.52 1.1e-24 Mean corpuscular volume; LUSC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg22437258 chr11:111473054 SIK2 0.52 7.46 0.38 7.5e-13 Primary sclerosing cholangitis; LUSC cis rs7923609 1.000 rs7910927 chr10:65138910 T/G cg01631684 chr10:65280961 REEP3 -0.38 -5.89 -0.31 9.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6964587 1.000 rs1063243 chr7:91726927 A/C cg17063962 chr7:91808500 NA 0.58 9.15 0.45 5.95e-18 Breast cancer; LUSC cis rs7246967 0.673 rs16999519 chr19:22814076 A/G cg23217946 chr19:22817039 ZNF492 -0.42 -6.25 -0.32 1.24e-9 Bronchopulmonary dysplasia; LUSC cis rs17270561 0.779 rs17271767 chr6:25886921 C/T cg16482183 chr6:26056742 HIST1H1C 0.85 11.43 0.53 9.3e-26 Iron status biomarkers; LUSC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg17264618 chr3:40429014 ENTPD3 0.3 6.42 0.33 4.71e-10 Renal cell carcinoma; LUSC cis rs1577917 0.958 rs11756615 chr6:86679835 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.87 -0.35 3.13e-11 Response to antipsychotic treatment; LUSC cis rs12986413 0.967 rs2108524 chr19:2170764 A/G cg09261902 chr19:2140048 AP3D1 0.31 5.89 0.31 9.44e-9 Height; LUSC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg20503657 chr10:835505 NA 0.78 9.73 0.47 7.08e-20 Eosinophil percentage of granulocytes; LUSC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg15445000 chr17:37608096 MED1 0.39 6.69 0.34 9.35e-11 Glomerular filtration rate (creatinine); LUSC cis rs13108904 0.870 rs3733338 chr4:1241472 G/A cg13395646 chr4:1353034 KIAA1530 -0.58 -9.17 -0.45 5.02e-18 Obesity-related traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15302530 chr7:108210038 THAP5;DNAJB9 -0.45 -6.17 -0.32 1.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.954 rs4345162 chr4:120312959 G/A cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg23711669 chr6:146136114 FBXO30 0.92 17.39 0.69 1.06e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs10464366 0.560 rs11763728 chr7:39145862 C/T cg10621924 chr7:39171070 POU6F2 0.43 6.77 0.35 5.76e-11 IgG glycosylation; LUSC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.56 0.42 4.3e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12971120 0.891 rs11151960 chr18:72177232 G/A cg26446133 chr18:72167187 CNDP2 -0.76 -9.18 -0.45 4.79e-18 Refractive error; LUSC trans rs9650657 0.707 rs11250076 chr8:10647823 A/G cg15556689 chr8:8085844 FLJ10661 -0.43 -6.45 -0.33 4.04e-10 Neuroticism; LUSC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg04824913 chr4:887549 GAK -0.68 -9.83 -0.47 3.37e-20 Systemic sclerosis; LUSC cis rs1790761 0.554 rs3758938 chr11:67402362 T/G cg00290607 chr11:67383545 NA -0.38 -6.42 -0.33 4.74e-10 Mean corpuscular volume; LUSC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.72 -7.23 -0.37 3.41e-12 Diabetic retinopathy; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -9.41 -0.46 8.21e-19 Platelet count; LUSC cis rs2073300 0.609 rs6137910 chr20:23346515 C/G cg12062639 chr20:23401060 NAPB 0.96 8.01 0.4 1.94e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3924048 0.559 rs4075304 chr1:12626803 C/T cg23650765 chr1:12612165 NA 0.29 5.88 0.31 9.88e-9 Optic cup area; LUSC cis rs10465746 0.935 rs12133778 chr1:84367626 A/G cg10977910 chr1:84465055 TTLL7 0.42 5.9 0.31 9.13e-9 Obesity-related traits; LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg04267008 chr7:1944627 MAD1L1 -0.6 -8.92 -0.44 3.07e-17 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg05368731 chr17:41323189 NBR1 0.94 16.26 0.66 3.47e-44 Menopause (age at onset); LUSC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg16624210 chr5:671434 TPPP 0.5 6.41 0.33 5.1e-10 Obesity-related traits; LUSC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg18876405 chr7:65276391 NA 0.58 9.51 0.46 3.99e-19 Aortic root size; LUSC cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg24112000 chr20:60950667 NA -0.45 -8.8 -0.43 7.65e-17 Colorectal cancer; LUSC cis rs2070488 0.775 rs7374458 chr3:38531211 T/G cg24069376 chr3:38537580 EXOG 0.41 7.88 0.4 4.77e-14 Electrocardiographic conduction measures; LUSC cis rs8099014 0.906 rs4245268 chr18:56096515 A/G cg12907477 chr18:56117327 MIR122 -0.41 -6.64 -0.34 1.27e-10 Platelet count; LUSC trans rs853679 0.517 rs9368553 chr6:28082265 T/C cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs1670533 1.000 rs13134921 chr4:1054177 A/G cg27284194 chr4:1044797 NA 0.59 8.84 0.44 5.65e-17 Recombination rate (females); LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs7759001 0.857 rs6904883 chr6:27357308 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.72 0.3 2.39e-8 Glomerular filtration rate (creatinine); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10089247 chr2:201754140 NIF3L1;PPIL3 -0.43 -6.39 -0.33 5.71e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7177699 0.526 rs7165733 chr15:79123505 G/A cg15571903 chr15:79123663 NA 0.34 6.34 0.33 7.41e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1355223 1.000 rs1396879 chr11:34766653 A/C cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.75 -0.3 2.04e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg08048268 chr3:133502702 NA -0.41 -7.4 -0.38 1.08e-12 Iron status biomarkers; LUSC cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg06484146 chr7:12443880 VWDE -0.62 -6.24 -0.32 1.36e-9 Coronary artery disease; LUSC cis rs1561176 0.783 rs1124175 chr7:155015124 A/C cg25063631 chr7:155025500 NA 0.49 6.29 0.33 9.81e-10 Personality dimensions; LUSC cis rs3540 0.553 rs12592611 chr15:91004093 C/T cg10434728 chr15:90938212 IQGAP1 0.42 8.43 0.42 1.06e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24623068 chr5:154317667 GEMIN5 -0.55 -6.64 -0.34 1.3100000000000001e-10 Bipolar disorder and schizophrenia; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg16405210 chr4:1374714 KIAA1530 -0.8 -13.61 -0.6 7.51e-34 Longevity; LUSC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg18904891 chr8:8559673 CLDN23 0.61 8.18 0.41 6.04e-15 Obesity-related traits; LUSC cis rs17345786 0.511 rs12639028 chr3:101346033 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.21 0.37 3.85e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9811920 0.809 rs4928153 chr3:99808445 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.51 -0.34 2.71e-10 Axial length; LUSC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg05861140 chr6:150128134 PCMT1 0.42 6.73 0.35 7.38e-11 Lung cancer; LUSC cis rs2651899 0.934 rs1627080 chr1:3081309 T/C cg22674798 chr1:3096360 PRDM16 0.3 6.72 0.35 7.9e-11 Migraine; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg09436375 chr6:42928200 GNMT -0.31 -7.29 -0.37 2.26e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg10117171 chr1:25599238 RHD -0.39 -6.07 -0.32 3.45e-9 Erythrocyte sedimentation rate; LUSC cis rs7615952 0.800 rs2062773 chr3:125639648 T/C cg05084668 chr3:125655381 ALG1L -0.77 -11.86 -0.54 2.63e-27 Blood pressure (smoking interaction); LUSC cis rs2197308 0.631 rs4882308 chr12:38446252 G/C cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.75e-15 Morning vs. evening chronotype; LUSC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.16 0.41 6.91e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11890956 chr21:40555474 PSMG1 1.03 20.65 0.75 1.23e-61 Cognitive function; LUSC cis rs2486288 0.656 rs2413773 chr15:45549442 C/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.86 -0.39 5.45e-14 Glomerular filtration rate; LUSC cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg16339924 chr4:17578868 LAP3 0.61 9.29 0.45 2.07e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2235544 0.579 rs1537321 chr1:54482236 C/A cg25741118 chr1:54482237 LDLRAD1 -0.34 -7.67 -0.39 1.89e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg14895029 chr7:2775587 GNA12 -0.4 -6.12 -0.32 2.57e-9 Height; LUSC cis rs7851660 0.809 rs12550872 chr9:100653128 G/A cg13688889 chr9:100608707 NA -0.53 -8.06 -0.4 1.36e-14 Strep throat; LUSC cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg05283184 chr6:79620031 NA -0.46 -8.73 -0.43 1.26e-16 Intelligence (multi-trait analysis); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg00325919 chr1:156595847 NA 0.41 6.26 0.32 1.16e-9 N-glycan levels; LUSC cis rs372883 0.935 rs1153294 chr21:30701096 A/G cg24692254 chr21:30365293 RNF160 -0.42 -5.95 -0.31 6.93e-9 Pancreatic cancer; LUSC cis rs16912285 0.688 rs35683920 chr11:24358521 A/G ch.11.24196551F chr11:24239977 NA 0.85 8.18 0.41 6.13e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1376303 0.643 rs12701264 chr7:32965040 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.64 5.72 0.3 2.4e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg11764359 chr7:65958608 NA -0.7 -10.98 -0.52 3.64e-24 Aortic root size; LUSC cis rs6500602 0.647 rs4785967 chr16:4523208 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.54 7.33 0.37 1.76e-12 Schizophrenia; LUSC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg17554472 chr22:41940697 POLR3H -0.45 -5.77 -0.3 1.77e-8 Vitiligo; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03172651 chr20:13201655 ISM1 0.74 6.6 0.34 1.6e-10 Cognitive performance; LUSC cis rs983392 0.678 rs1426253 chr11:59981218 A/C cg20284999 chr11:59952153 MS4A6A -0.36 -6.08 -0.32 3.24e-9 Alzheimer's disease (late onset); LUSC cis rs17270561 0.636 rs9348696 chr6:25781938 A/G cg17691542 chr6:26056736 HIST1H1C 0.5 7.01 0.36 1.3e-11 Iron status biomarkers; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg02796970 chr10:39023768 NA -0.48 -7.64 -0.39 2.24e-13 Menopause (age at onset); LUSC cis rs3008870 1.000 rs2755250 chr1:67495283 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.96 15.61 0.65 1.2e-41 Lymphocyte percentage of white cells; LUSC cis rs6696846 0.740 rs11240369 chr1:205115099 G/A cg21545522 chr1:205238299 TMCC2 0.46 8.63 0.43 2.51e-16 Red blood cell count; LUSC trans rs7824557 0.707 rs3808519 chr8:11142970 C/G cg06636001 chr8:8085503 FLJ10661 0.54 8.42 0.42 1.15e-15 Retinal vascular caliber; LUSC trans rs62103177 0.713 rs62103186 chr18:77627574 G/C cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg10253484 chr15:75165896 SCAMP2 -0.6 -8.36 -0.42 1.67e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs1113500 0.933 rs11185250 chr1:108616417 A/G cg11967332 chr1:108735228 SLC25A24 0.4 5.88 0.31 1.01e-8 Growth-regulated protein alpha levels; LUSC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg17971929 chr21:40555470 PSMG1 0.77 13.53 0.6 1.44e-33 Cognitive function; LUSC cis rs6121246 0.697 rs6087716 chr20:30229040 C/T cg18721089 chr20:30220636 NA -0.41 -6.85 -0.35 3.62e-11 Mean corpuscular hemoglobin; LUSC cis rs6940638 0.715 rs9348751 chr6:27067190 T/A cg12292205 chr6:26970375 C6orf41 -0.39 -5.73 -0.3 2.3e-8 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg00945038 chr17:61921165 SMARCD2 0.51 8.74 0.43 1.12e-16 Prudent dietary pattern; LUSC cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg10224037 chr5:178157518 ZNF354A -0.88 -12.92 -0.58 3.12e-31 Neutrophil percentage of white cells; LUSC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg22834771 chr12:69754056 YEATS4 -0.48 -6.89 -0.35 2.77e-11 Cerebrospinal fluid biomarker levels; LUSC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg13206674 chr6:150067644 NUP43 0.57 9.01 0.44 1.6e-17 Lung cancer; LUSC cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg13256891 chr4:100009986 ADH5 0.51 7.03 0.36 1.21e-11 Smoking initiation; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26035323 chr1:44871156 RNF220 -0.5 -6.39 -0.33 5.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs9814567 1.000 rs9990351 chr3:134239191 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.77 12.56 0.57 6.99e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6121246 0.559 rs10439607 chr20:30258541 G/A cg21427119 chr20:30132790 HM13 -0.35 -5.75 -0.3 2.06e-8 Mean corpuscular hemoglobin; LUSC cis rs11676348 0.772 rs12694427 chr2:218945045 C/T cg06547715 chr2:218990976 CXCR2 0.3 5.78 0.3 1.7e-8 Ulcerative colitis; LUSC trans rs9650657 0.707 rs4841452 chr8:10687121 A/G cg15556689 chr8:8085844 FLJ10661 -0.41 -6.13 -0.32 2.42e-9 Neuroticism; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.81 0.43 7.03e-17 Prudent dietary pattern; LUSC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg22800045 chr5:56110881 MAP3K1 0.46 6.16 0.32 2.05e-9 Coronary artery disease; LUSC cis rs4268898 0.662 rs72795824 chr2:24435837 T/C cg06627628 chr2:24431161 ITSN2 -0.89 -13.28 -0.59 1.29e-32 Asthma; LUSC cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg16586182 chr3:47516702 SCAP 0.52 8.18 0.41 6.15e-15 Colorectal cancer; LUSC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg03676636 chr4:99064102 C4orf37 0.33 7.22 0.37 3.42e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4776059 1.000 rs11857150 chr15:52922216 G/A cg22715398 chr15:52968154 KIAA1370 -0.65 -9.54 -0.46 3.02e-19 Schizophrenia; LUSC cis rs7605378 1.000 rs7605378 chr2:200676926 A/C cg23649088 chr2:200775458 C2orf69 0.5 7.55 0.38 4.27e-13 Osteoporosis; LUSC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg06238570 chr21:40685208 BRWD1 0.6 9.89 0.48 2.14e-20 Cognitive function; LUSC cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg00071950 chr4:10020882 SLC2A9 0.53 8.89 0.44 3.85e-17 Bone mineral density; LUSC cis rs17095355 0.818 rs10509907 chr10:111781715 T/C cg00817464 chr10:111662876 XPNPEP1 -0.58 -6.72 -0.34 8.01e-11 Biliary atresia; LUSC cis rs8036030 0.604 rs11856835 chr15:74716174 G/A cg05926586 chr15:74592786 CCDC33 0.3 5.99 0.31 5.39e-9 Airflow obstruction; LUSC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg11494091 chr17:61959527 GH2 0.38 6.63 0.34 1.36e-10 Height; LUSC cis rs2760061 0.583 rs3094911 chr1:228210179 A/G cg18477163 chr1:228402036 OBSCN 0.57 9.83 0.47 3.47e-20 Diastolic blood pressure; LUSC cis rs61931739 0.534 rs7138522 chr12:34039762 G/A cg06521331 chr12:34319734 NA -0.48 -7.71 -0.39 1.43e-13 Morning vs. evening chronotype; LUSC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18099408 chr3:52552593 STAB1 0.39 6.97 0.36 1.65e-11 Electroencephalogram traits; LUSC trans rs7829975 0.688 rs7837587 chr8:8378992 T/C cg21775007 chr8:11205619 TDH 0.44 6.53 0.34 2.51e-10 Mood instability; LUSC cis rs13253111 0.624 rs7357359 chr8:28094835 T/C cg26534493 chr8:28060551 NA 0.38 6.91 0.35 2.47e-11 Childhood body mass index; LUSC cis rs11170631 0.507 rs12307701 chr12:54090724 A/C cg23533419 chr12:54090519 NA -0.38 -6.22 -0.32 1.45e-9 Height; LUSC cis rs8062405 0.698 rs8046545 chr16:28915217 G/A cg05966235 chr16:28915196 ATP2A1 -0.36 -6.07 -0.32 3.53e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs295140 0.506 rs295136 chr2:201141002 G/C cg23649088 chr2:200775458 C2orf69 0.4 5.98 0.31 5.89e-9 QT interval; LUSC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs11098499 1.000 rs11726229 chr4:120211580 C/T cg24375607 chr4:120327624 NA 0.73 10.73 0.51 2.81e-23 Corneal astigmatism; LUSC cis rs644799 0.601 rs662168 chr11:95586982 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.39 0.49 4.2e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9902453 1.000 rs4575590 chr17:28361969 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg20243544 chr17:37824526 PNMT 0.48 6.06 0.31 3.67e-9 Glomerular filtration rate (creatinine); LUSC trans rs7937682 0.883 rs542831 chr11:111471392 T/A cg18187862 chr3:45730750 SACM1L 0.51 6.52 0.34 2.59e-10 Primary sclerosing cholangitis; LUSC cis rs11031096 0.727 rs7932702 chr11:4124372 C/T cg08557956 chr11:4115526 RRM1 -0.41 -5.65 -0.3 3.52e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg24846343 chr22:24311635 DDTL 0.41 6.47 0.33 3.56e-10 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg00933542 chr6:150070202 PCMT1 0.33 7.04 0.36 1.11e-11 Lung cancer; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg16647868 chr5:131706066 SLC22A5 0.42 6.58 0.34 1.81e-10 Breast cancer; LUSC cis rs908922 0.887 rs4845783 chr1:152492559 G/A cg20991723 chr1:152506922 NA 0.52 9.06 0.44 1.15e-17 Hair morphology; LUSC cis rs7200543 0.883 rs4985148 chr16:15147788 A/C cg03427771 chr16:15082598 PDXDC1 -0.41 -5.94 -0.31 7.2e-9 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.84 -0.3 1.22e-8 Platelet count; LUSC cis rs12579753 1.000 rs17748942 chr12:82170478 G/A cg07988820 chr12:82153109 PPFIA2 -0.44 -6.2 -0.32 1.7e-9 Resting heart rate; LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg18402987 chr7:1209562 NA 0.71 7.55 0.38 4.11e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.37 -0.33 6.24e-10 Neuroticism; LUSC cis rs2637266 0.783 rs7914756 chr10:78476406 A/T cg18941641 chr10:78392320 NA -0.34 -6.15 -0.32 2.16e-9 Pulmonary function; LUSC cis rs6570726 0.967 rs9403706 chr6:145795187 C/T cg05347473 chr6:146136440 FBXO30 -0.38 -6.31 -0.33 9.11e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1018836 0.770 rs12543806 chr8:91664011 C/T cg16814680 chr8:91681699 NA -0.98 -18.94 -0.72 7.58e-55 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19127360 chr2:242089945 PPP1R7;PASK -0.41 -6.22 -0.32 1.47e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4820539 1.000 rs4820539 chr22:23477970 C/T cg21100191 chr22:23484243 RTDR1 -0.86 -14.83 -0.63 1.42e-38 Bone mineral density; LUSC cis rs9486719 0.857 rs2971609 chr6:97039665 A/G cg06623918 chr6:96969491 KIAA0776 -0.85 -12.48 -0.56 1.3e-29 Migraine;Coronary artery disease; LUSC cis rs4812048 1.000 rs6070692 chr20:57586374 A/G cg14073986 chr20:57617431 SLMO2 0.59 6.28 0.33 1.04e-9 Mean platelet volume; LUSC cis rs7106204 0.609 rs10500976 chr11:24335921 A/G ch.11.24196551F chr11:24239977 NA -0.64 -6.07 -0.32 3.46e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6500395 0.925 rs6500396 chr16:48625458 A/T cg04672837 chr16:48644449 N4BP1 0.5 7.42 0.38 9.77e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504073 0.647 rs28685207 chr8:50003484 A/G cg00325661 chr8:49890786 NA 0.62 10.3 0.49 8.96e-22 Blood metabolite ratios; LUSC cis rs11098499 0.863 rs3775848 chr4:120447724 C/T cg09307838 chr4:120376055 NA 0.73 10.22 0.49 1.58e-21 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17017152 chr1:61547389 NFIA 0.44 6.52 0.34 2.64e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs757081 0.637 rs586785 chr11:17208714 T/C cg15432903 chr11:17409602 KCNJ11 -0.38 -5.91 -0.31 8.41e-9 Systolic blood pressure; LUSC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.15 -0.32 2.26e-9 Lung cancer; LUSC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6681460 1.000 rs7521123 chr1:67121663 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.99 0.44 1.94e-17 Presence of antiphospholipid antibodies; LUSC cis rs1775715 0.677 rs2808074 chr10:32179184 A/C cg04359828 chr10:32216031 ARHGAP12 0.39 6.65 0.34 1.17e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg07777115 chr5:623756 CEP72 -0.45 -5.68 -0.3 2.98e-8 Obesity-related traits; LUSC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs9346649 0.616 rs1873337 chr6:168492160 T/G cg02770688 chr6:168491649 NA 0.48 9.08 0.45 9.54e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs78572108 0.858 rs4952583 chr2:42268688 C/T cg00607755 chr2:42274082 PKDCC 0.35 5.93 0.31 7.47e-9 Total body bone mineral density; LUSC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg05368731 chr17:41323189 NBR1 0.83 13.9 0.61 5.72e-35 Menopause (age at onset); LUSC cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg05347473 chr6:146136440 FBXO30 0.53 8.91 0.44 3.27e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs62400317 0.859 rs10948219 chr6:45229307 A/T cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.55 -0.42 4.48e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6009527 1.000 rs737834 chr22:49573190 C/T cg12746016 chr22:49560550 NA 0.36 6.09 0.32 3.09e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs12541635 0.677 rs7460291 chr8:107057861 A/G cg10147462 chr8:107024639 NA 0.66 13.77 0.6 1.77e-34 Age of smoking initiation; LUSC cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg15839431 chr19:19639596 YJEFN3 0.66 7.28 0.37 2.39e-12 Bipolar disorder; LUSC cis rs2282802 0.685 rs1529693 chr5:139678213 A/G cg26211634 chr5:139558579 C5orf32 0.38 7.13 0.36 6.33e-12 Intelligence (multi-trait analysis); LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg25767906 chr1:53392781 SCP2 -0.52 -9.58 -0.46 2.27e-19 Monocyte count; LUSC cis rs66573146 0.656 rs41410847 chr4:6957332 C/T cg26116260 chr4:7069785 GRPEL1 -0.71 -6.52 -0.34 2.67e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg26314531 chr2:26401878 FAM59B 0.68 8.53 0.42 5.02e-16 Gut microbiome composition (summer); LUSC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.45 6.24 0.32 1.33e-9 Multiple sclerosis; LUSC trans rs9929218 0.581 rs7203337 chr16:68774800 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.99 20.29 0.74 3.32e-60 Colorectal cancer; LUSC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.66 -0.34 1.14e-10 Monocyte percentage of white cells; LUSC cis rs17661538 0.542 rs11592688 chr10:18422535 T/G cg03634479 chr10:18430412 CACNB2 0.59 5.78 0.3 1.7e-8 Response to antipsychotic treatment; LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.13 0.41 8.57e-15 Homoarginine levels; LUSC trans rs5756813 0.635 rs4820301 chr22:38126364 G/A cg19894588 chr14:64061835 NA -0.51 -6.61 -0.34 1.48e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs4363385 0.510 rs11205187 chr1:153053323 T/C cg25856811 chr1:152973957 SPRR3 -0.38 -6.22 -0.32 1.52e-9 Inflammatory skin disease; LUSC trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg17470723 chr8:74884337 TCEB1 0.53 8.16 0.41 6.81e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18450072 chr4:40058936 LOC344967;N4BP2 -0.48 -6.11 -0.32 2.84e-9 Bipolar disorder and schizophrenia; LUSC cis rs17407555 0.697 rs73212821 chr4:10069451 T/A cg00071950 chr4:10020882 SLC2A9 -0.52 -6.44 -0.33 4.12e-10 Schizophrenia (age at onset); LUSC cis rs10979 1.000 rs9390110 chr6:143893413 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.14 -0.55 2.4e-28 Hypospadias; LUSC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg11764359 chr7:65958608 NA -0.78 -12.7 -0.57 2.07e-30 Aortic root size; LUSC cis rs9660992 0.736 rs55673946 chr1:205250475 T/C cg21643547 chr1:205240462 TMCC2 -0.49 -9.36 -0.46 1.17e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg19346786 chr7:2764209 NA -0.39 -6.99 -0.36 1.54e-11 Height; LUSC cis rs6840360 0.593 rs1429559 chr4:152681952 A/G cg22705602 chr4:152727874 NA -0.34 -7.58 -0.38 3.36e-13 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg00310523 chr12:86230176 RASSF9 0.44 8.2 0.41 5.3e-15 Major depressive disorder; LUSC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.8 14.04 0.61 1.66e-35 Total body bone mineral density; LUSC trans rs35110281 0.805 rs2838318 chr21:44991825 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 9.19 0.45 4.38e-18 Mean corpuscular volume; LUSC cis rs7180079 0.844 rs11071791 chr15:64602270 C/A cg08069370 chr15:64387884 SNX1 0.53 5.72 0.3 2.32e-8 Monocyte count; LUSC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg07777115 chr5:623756 CEP72 -0.47 -5.9 -0.31 9.07e-9 Obesity-related traits; LUSC trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.26 0.41 3.47e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9427116 0.502 rs3766922 chr1:154577055 A/C cg17218026 chr1:154582156 ADAR 0.55 10.07 0.48 5.33e-21 Blood protein levels; LUSC cis rs6580649 0.843 rs3803184 chr12:48398002 G/C cg24011408 chr12:48396354 COL2A1 0.55 7.6 0.38 3.01e-13 Lung cancer; LUSC cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.33 -0.37 1.73e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs61990749 0.597 rs117131659 chr14:78131126 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.58 -6.26 -0.32 1.16e-9 Fibroblast growth factor basic levels; LUSC cis rs11148252 0.740 rs7981050 chr13:52755149 C/T cg00495681 chr13:53174319 NA 0.48 7.62 0.38 2.6e-13 Lewy body disease; LUSC cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg27490568 chr2:178487706 NA 0.4 6.0 0.31 5.19e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.32 -0.33 8.54e-10 Lung cancer; LUSC cis rs1538970 1.000 rs9326141 chr1:45828943 A/G cg06784218 chr1:46089804 CCDC17 -0.33 -6.02 -0.31 4.51e-9 Platelet count; LUSC cis rs7508 0.618 rs13266287 chr8:17871598 T/A cg01800426 chr8:17659068 MTUS1 -0.41 -5.99 -0.31 5.51e-9 Atrial fibrillation; LUSC cis rs77741769 0.571 rs11065311 chr12:121324115 A/T cg02419362 chr12:121203948 SPPL3 -0.41 -7.56 -0.38 4.02e-13 Mean corpuscular volume; LUSC cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC cis rs11605275 0.792 rs2568131 chr11:20046407 G/T cg14835545 chr11:20032148 NAV2 0.6 6.02 0.31 4.59e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1801251 1.000 rs11676216 chr2:233706368 C/T cg25237894 chr2:233734115 C2orf82 -0.36 -6.81 -0.35 4.67e-11 Coronary artery disease; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg21280719 chr6:42927975 GNMT -0.31 -7.75 -0.39 1.13e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg20503657 chr10:835505 NA 0.98 14.18 0.61 4.77e-36 Eosinophil percentage of granulocytes; LUSC cis rs2932538 0.922 rs6658555 chr1:113098534 C/T cg22162597 chr1:113214053 CAPZA1 0.7 9.89 0.48 2.21e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs4689388 0.890 rs4481292 chr4:6298375 C/T cg00701064 chr4:6280414 WFS1 0.61 15.07 0.64 1.62e-39 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg17554472 chr22:41940697 POLR3H -0.47 -5.74 -0.3 2.18e-8 Vitiligo; LUSC cis rs34638657 0.732 rs62045964 chr16:82200920 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.31 -0.33 8.83e-10 Lung adenocarcinoma; LUSC cis rs2932538 0.922 rs11102508 chr1:113141175 T/C cg22162597 chr1:113214053 CAPZA1 0.53 7.64 0.39 2.37e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg25173405 chr17:45401733 C17orf57 0.36 5.72 0.3 2.32e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4843747 0.671 rs28671027 chr16:88116323 G/A cg17633681 chr16:88106987 BANP 0.5 9.45 0.46 5.93e-19 Menopause (age at onset); LUSC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -11.74 -0.54 7.33e-27 Systemic lupus erythematosus; LUSC cis rs7945705 0.846 rs11042055 chr11:8756856 G/A cg12365402 chr11:9010492 NRIP3 0.44 7.57 0.38 3.74e-13 Hemoglobin concentration; LUSC cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg11663144 chr21:46675770 NA -0.41 -7.23 -0.37 3.33e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7089973 0.966 rs36089581 chr10:116623059 G/C cg23260525 chr10:116636907 FAM160B1 0.39 7.57 0.38 3.74e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20018234 chr1:156084659 LMNA 0.74 6.01 0.31 4.8e-9 Cognitive performance; LUSC trans rs9929218 0.953 rs16260 chr16:68771034 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -12.24 -0.56 1.03e-28 Colorectal cancer; LUSC trans rs12310956 0.532 rs10844719 chr12:33987714 A/G cg26384229 chr12:38710491 ALG10B 0.7 10.87 0.51 9.4e-24 Morning vs. evening chronotype; LUSC trans rs9929218 0.954 rs12599393 chr16:68829021 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -10.87 -0.51 8.82e-24 Colorectal cancer; LUSC cis rs8017423 0.608 rs12589866 chr14:90820977 T/C cg04374321 chr14:90722782 PSMC1 -0.44 -6.61 -0.34 1.57e-10 Mortality in heart failure; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.46 0.53 7.44e-26 Menopause (age at onset); LUSC cis rs4076764 0.522 rs10799914 chr1:163353205 A/G cg24596788 chr1:163392923 NA -0.34 -5.72 -0.3 2.34e-8 Motion sickness; LUSC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg19592336 chr6:28129416 ZNF389 0.49 6.78 0.35 5.54e-11 Parkinson's disease; LUSC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg17724175 chr1:150552817 MCL1 0.37 6.69 0.34 9.15e-11 Tonsillectomy; LUSC trans rs2950393 0.804 rs2958130 chr12:57140506 G/A cg14367344 chr1:146644336 PRKAB2 -0.42 -5.99 -0.31 5.57e-9 Platelet distribution width; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08868379 chr11:75946452 NA -0.4 -6.09 -0.32 3.13e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg12463550 chr7:65579703 CRCP 0.42 6.0 0.31 5.11e-9 Calcium levels; LUSC cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.72 0.43 1.29e-16 Menopause (age at onset); LUSC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg26924012 chr15:45694286 SPATA5L1 1.07 17.48 0.69 4.61e-49 Homoarginine levels; LUSC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg13628971 chr7:2884303 GNA12 0.43 6.27 0.32 1.11e-9 Height; LUSC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg11663144 chr21:46675770 NA -0.42 -7.34 -0.37 1.66e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6138458 1.000 rs11906373 chr20:24938832 A/G cg06937882 chr20:24974362 C20orf3 -0.42 -7.22 -0.37 3.45e-12 Blood protein levels; LUSC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -7.36 -0.37 1.41e-12 Reticulocyte count; LUSC cis rs911119 1.000 rs3787499 chr20:23616807 G/A cg16589663 chr20:23618590 CST3 0.6 6.99 0.36 1.48e-11 Chronic kidney disease; LUSC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22307029 chr19:49891270 CCDC155 0.67 9.59 0.46 2.12e-19 Multiple sclerosis; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg26354017 chr1:205819088 PM20D1 0.79 15.1 0.64 1.22e-39 Monocyte percentage of white cells; LUSC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg27068330 chr11:65405492 SIPA1 -0.46 -6.0 -0.31 5.25e-9 Breast cancer; LUSC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg16325326 chr1:53192061 ZYG11B -1.0 -20.85 -0.75 1.94e-62 Monocyte count; LUSC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg19077165 chr18:44547161 KATNAL2 -0.38 -5.76 -0.3 1.92e-8 Personality dimensions; LUSC cis rs12681287 0.546 rs11539113 chr8:87497176 G/A cg00550725 chr8:87521180 FAM82B 0.44 5.81 0.3 1.48e-8 Caudate activity during reward; LUSC cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.84 0.51 1.21e-23 Heart rate; LUSC trans rs2282032 1.000 rs75722521 chr14:90760478 T/C cg11965331 chr8:7651924 NA 0.42 5.97 0.31 6.07e-9 Longevity; LUSC cis rs9517320 1.000 rs7996629 chr13:99128037 C/T cg07423050 chr13:99094983 FARP1 0.34 6.33 0.33 8.08e-10 Longevity; LUSC cis rs9920506 0.536 rs11636605 chr15:78928878 A/G cg24631222 chr15:78858424 CHRNA5 -0.56 -7.14 -0.36 5.72e-12 Post bronchodilator FEV1; LUSC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg22437258 chr11:111473054 SIK2 0.53 7.53 0.38 4.93e-13 Primary sclerosing cholangitis; LUSC cis rs2882667 0.690 rs825747 chr5:138136585 C/T cg04439458 chr5:138467593 SIL1 0.4 7.18 0.37 4.6e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg18681998 chr4:17616180 MED28 -0.82 -14.58 -0.62 1.34e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg08859206 chr1:53392774 SCP2 0.5 8.51 0.42 6.03e-16 Monocyte count; LUSC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs12579753 1.000 rs11115030 chr12:82203021 A/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.12 -0.32 2.69e-9 Resting heart rate; LUSC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg08280861 chr8:58055591 NA 0.53 5.73 0.3 2.22e-8 Developmental language disorder (linguistic errors); LUSC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg17179660 chr6:151773299 C6orf211;RMND1 -0.47 -6.84 -0.35 3.75e-11 Menarche (age at onset); LUSC cis rs9300255 0.543 rs1260294 chr12:123560289 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.39 5.75 0.3 2.04e-8 Neutrophil percentage of white cells; LUSC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.09 -0.32 3.04e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2708377 0.929 rs1817043 chr12:11215852 G/A cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs4343996 0.565 rs13246563 chr7:3438243 C/G cg21248987 chr7:3385318 SDK1 0.34 5.66 0.3 3.27e-8 Motion sickness; LUSC cis rs3858526 0.834 rs7939099 chr11:5995792 G/A cg25319279 chr11:5960081 NA -0.41 -5.76 -0.3 1.93e-8 DNA methylation (variation); LUSC cis rs354225 0.584 rs9677089 chr2:54794927 A/C cg26097391 chr2:54893211 SPTBN1 0.4 6.06 0.31 3.64e-9 Schizophrenia; LUSC trans rs7726839 0.540 rs4957081 chr5:646418 G/C cg25482853 chr8:67687455 SGK3 1.1 15.65 0.65 8.75e-42 Obesity-related traits; LUSC cis rs4727027 0.704 rs12535115 chr7:148895087 C/T cg23583168 chr7:148888333 NA -0.9 -17.73 -0.7 4.8e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11018904 0.906 rs11603498 chr11:89928783 C/A cg26138821 chr11:89956704 CHORDC1 -0.6 -6.87 -0.35 3.24e-11 Intelligence (multi-trait analysis); LUSC cis rs1167827 0.680 rs1167800 chr7:75176196 G/A cg09988129 chr7:74988866 PMS2L2;STAG3L1 0.39 5.79 0.3 1.66e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10733682 0.659 rs4358894 chr9:129464802 C/G cg00232160 chr9:129468157 NA 0.39 6.95 0.36 1.9e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg05347473 chr6:146136440 FBXO30 0.54 9.3 0.45 1.87e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7709377 0.597 rs7732346 chr5:115502248 A/T cg23108291 chr5:115420582 COMMD10 0.42 5.96 0.31 6.35e-9 Metabolite levels (X-11787); LUSC cis rs2354432 0.607 rs2297752 chr1:146765454 C/G cg25205988 chr1:146714368 CHD1L -1.02 -10.76 -0.51 2.28e-23 Mitochondrial DNA levels; LUSC cis rs9790314 1.000 rs4597724 chr3:160963110 A/G cg04691961 chr3:161091175 C3orf57 -0.35 -5.94 -0.31 7.08e-9 Morning vs. evening chronotype; LUSC cis rs6977660 0.652 rs10274428 chr7:19850592 C/T cg07541023 chr7:19748670 TWISTNB 0.54 5.68 0.3 2.89e-8 Thyroid stimulating hormone; LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg21724239 chr8:58056113 NA 0.8 8.44 0.42 9.52e-16 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg17724175 chr1:150552817 MCL1 0.32 5.74 0.3 2.08e-8 Melanoma; LUSC trans rs2262909 1.000 rs2359821 chr19:22208314 C/T cg17074339 chr11:11642133 GALNTL4 -0.41 -6.2 -0.32 1.68e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4803468 0.967 rs4803461 chr19:41908871 G/A cg09537434 chr19:41945824 ATP5SL -0.9 -16.12 -0.66 1.16e-43 Height; LUSC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg24675056 chr1:15929824 NA 0.5 8.74 0.43 1.18e-16 Systolic blood pressure; LUSC cis rs912057 0.833 rs1294418 chr6:6742185 A/G cg06612196 chr6:6737390 NA 0.56 10.53 0.5 1.42e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Parkinson's disease; LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg00149659 chr3:10157352 C3orf10 0.89 12.11 0.55 3.04e-28 Alzheimer's disease; LUSC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg11663144 chr21:46675770 NA -0.41 -7.03 -0.36 1.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3808502 0.503 rs2061830 chr8:11397457 C/G cg08975724 chr8:8085496 FLJ10661 0.54 8.11 0.41 9.83e-15 Neuroticism; LUSC cis rs6541297 1.000 rs6681042 chr1:230278979 G/A cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.22e-15 Coronary artery disease; LUSC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg06008330 chr7:65541103 ASL -0.36 -5.65 -0.3 3.53e-8 Aortic root size; LUSC cis rs1865760 0.519 rs4360119 chr6:25815074 C/G cg17691542 chr6:26056736 HIST1H1C 0.52 7.04 0.36 1.07e-11 Height; LUSC cis rs992157 0.735 rs10932765 chr2:219099484 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.81 0.39 7.61e-14 Colorectal cancer; LUSC cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg04267008 chr7:1944627 MAD1L1 -0.52 -7.8 -0.39 7.99e-14 Bipolar disorder and schizophrenia; LUSC cis rs12760731 0.623 rs12239670 chr1:178377761 G/T cg00404053 chr1:178313656 RASAL2 0.48 5.74 0.3 2.16e-8 Obesity-related traits; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg13397359 chr6:42928475 GNMT 0.57 9.57 0.46 2.4e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.8 -0.35 4.8e-11 Alzheimer's disease (late onset); LUSC cis rs7267979 1.000 rs2258135 chr20:25272323 C/A cg08601574 chr20:25228251 PYGB 0.43 6.53 0.34 2.4e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2262909 0.925 rs73019838 chr19:22247732 T/A cg11619707 chr19:22235551 ZNF257 0.39 5.84 0.3 1.22e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg02038168 chr22:39784481 NA 0.49 8.2 0.41 5.4e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs11098499 0.779 rs7356491 chr4:120381974 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.44 0.33 4.04e-10 Corneal astigmatism; LUSC trans rs7980799 0.772 rs6488162 chr12:33593127 T/C cg26384229 chr12:38710491 ALG10B -0.46 -6.51 -0.34 2.83e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2303282 0.664 rs2617846 chr16:56397153 G/A cg00500540 chr16:56394104 NA -0.4 -6.96 -0.36 1.76e-11 Breast cancer; LUSC cis rs734999 0.549 rs3828154 chr1:2524943 G/A cg18932078 chr1:2524107 MMEL1 0.29 6.43 0.33 4.29e-10 Ulcerative colitis; LUSC cis rs1580019 0.961 rs1868777 chr7:32494076 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.69 9.97 0.48 1.11e-20 Cognitive ability; LUSC cis rs2760061 0.583 rs1636195 chr1:228211589 T/C cg18477163 chr1:228402036 OBSCN 0.57 9.57 0.46 2.49e-19 Diastolic blood pressure; LUSC cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg18132916 chr6:79620363 NA -0.38 -5.74 -0.3 2.18e-8 Intelligence (multi-trait analysis); LUSC cis rs7091068 0.706 rs1147644 chr10:95400947 A/G cg20715218 chr10:95462985 C10orf4 -0.52 -5.69 -0.3 2.76e-8 Urinary tract infection frequency; LUSC cis rs56235845 0.694 rs11738681 chr5:176761535 A/G cg06060754 chr5:176797920 RGS14 0.58 9.08 0.45 9.43e-18 Hemoglobin concentration;Hematocrit; LUSC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg09365446 chr1:150670422 GOLPH3L -0.53 -7.79 -0.39 8.71e-14 Melanoma; LUSC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg25019033 chr10:957182 NA -0.53 -6.81 -0.35 4.62e-11 Eosinophil percentage of granulocytes; LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.09 -0.48 4.36e-21 Electroencephalogram traits; LUSC cis rs9467773 0.620 rs9461276 chr6:26595168 T/C cg11502198 chr6:26597334 ABT1 0.71 11.81 0.54 3.94e-27 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.867 rs3213991 chr15:43670280 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.91 9.69 0.47 9.79e-20 Lung cancer in ever smokers; LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.77 8.19 0.41 5.73e-15 Schizophrenia; LUSC cis rs1570884 0.516 rs2094108 chr13:50171550 G/A cg03651054 chr13:50194643 NA 0.36 6.24 0.32 1.29e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.71e-13 Electroencephalogram traits; LUSC cis rs6542838 0.609 rs13028500 chr2:99528296 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -6.06 -0.31 3.74e-9 Fear of minor pain; LUSC cis rs9443189 0.526 rs10943255 chr6:76225928 T/A cg01950844 chr6:76311363 SENP6 0.66 6.56 0.34 2.08e-10 Prostate cancer; LUSC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.42 6.5 0.34 2.95e-10 Platelet count; LUSC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg19920283 chr7:105172520 RINT1 0.58 6.25 0.32 1.25e-9 Bipolar disorder (body mass index interaction); LUSC trans rs11098499 0.738 rs34566984 chr4:120361270 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.18 0.41 5.96e-15 Corneal astigmatism; LUSC trans rs1493916 0.601 rs7237379 chr18:31322540 C/T cg27147174 chr7:100797783 AP1S1 0.56 8.79 0.43 7.87e-17 Life satisfaction; LUSC cis rs28595532 0.702 rs72670252 chr4:119337546 A/C cg21605333 chr4:119757512 SEC24D 1.02 8.34 0.42 1.96e-15 Cannabis dependence symptom count; LUSC cis rs738322 0.967 rs6001038 chr22:38570585 A/G cg17652424 chr22:38574118 PLA2G6 -0.29 -6.41 -0.33 5e-10 Cutaneous nevi; LUSC cis rs7264396 0.561 rs6142470 chr20:34570579 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.66 -0.34 1.1e-10 Total cholesterol levels; LUSC cis rs367615 0.506 rs2963013 chr5:108775811 C/T cg17395555 chr5:108820864 NA -0.55 -10.49 -0.5 1.86e-22 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9928842 0.882 rs9927264 chr16:75260241 T/C cg09066997 chr16:75300724 BCAR1 0.52 6.57 0.34 1.93e-10 Alcoholic chronic pancreatitis; LUSC cis rs1577917 0.958 rs12198876 chr6:86525476 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.64 -8.91 -0.44 3.36e-17 Response to antipsychotic treatment; LUSC cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg06552810 chr11:31128660 NA -0.4 -7.08 -0.36 8.78e-12 Bone mineral density (spine); LUSC cis rs2898290 0.617 rs13278965 chr8:11466745 A/T cg27411982 chr8:10470053 RP1L1 0.43 6.83 0.35 4.14e-11 Systolic blood pressure; LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg17178900 chr1:205818956 PM20D1 0.74 11.88 0.55 2.16e-27 Menarche (age at onset); LUSC trans rs11098499 0.909 rs28714195 chr4:120316950 A/T cg25214090 chr10:38739885 LOC399744 0.53 7.68 0.39 1.73e-13 Corneal astigmatism; LUSC trans rs61931739 0.782 rs3903201 chr12:34248275 G/A cg24313572 chr1:56050060 NA -0.31 -6.38 -0.33 5.9e-10 Morning vs. evening chronotype; LUSC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg08847533 chr14:75593920 NEK9 -0.66 -10.86 -0.51 9.51e-24 Coronary artery disease; LUSC cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg21770322 chr7:97807741 LMTK2 0.57 10.55 0.5 1.2e-22 Breast cancer; LUSC cis rs6424115 0.830 rs1105 chr1:24200800 T/C cg10978503 chr1:24200527 CNR2 0.54 13.3 0.59 1.11e-32 Immature fraction of reticulocytes; LUSC cis rs907683 0.584 rs1058284 chr2:220286142 G/A cg15015639 chr2:220282977 DES -0.31 -7.23 -0.37 3.27e-12 Resting heart rate; LUSC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg12463550 chr7:65579703 CRCP 0.51 7.38 0.37 1.26e-12 Aortic root size; LUSC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg05313129 chr8:58192883 C8orf71 -0.45 -5.92 -0.31 8.01e-9 Developmental language disorder (linguistic errors); LUSC cis rs11214589 0.905 rs1078 chr11:113241877 C/T cg14159747 chr11:113255604 NA 0.29 7.02 0.36 1.22e-11 Neuroticism; LUSC cis rs12893668 0.703 rs55751606 chr14:104028806 G/A cg08213375 chr14:104286397 PPP1R13B 0.36 5.94 0.31 7.22e-9 Reticulocyte count; LUSC cis rs11031096 0.782 rs10835684 chr11:4168308 G/T cg18678763 chr11:4115507 RRM1 -0.51 -7.52 -0.38 5.19e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9811920 0.555 rs68092024 chr3:99691522 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.74 -0.35 7.14e-11 Axial length; LUSC cis rs34779708 0.966 rs1213392 chr10:35430285 C/T cg04310649 chr10:35416472 CREM -0.4 -6.28 -0.32 1.06e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6500602 0.727 rs8051389 chr16:4570570 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.68 0.39 1.72e-13 Schizophrenia; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg03354898 chr7:1950403 MAD1L1 -0.44 -8.97 -0.44 2.21e-17 Bipolar disorder and schizophrenia; LUSC cis rs2070488 0.699 rs6599205 chr3:38529440 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 12.27 0.56 8.05e-29 Electrocardiographic conduction measures; LUSC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg04282206 chr17:62833786 PLEKHM1P -0.41 -6.02 -0.31 4.53e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg17724175 chr1:150552817 MCL1 0.36 6.51 0.34 2.7e-10 Tonsillectomy; LUSC trans rs11088226 0.846 rs13047501 chr21:33924660 G/A cg09050820 chr6:167586206 TCP10L2 0.65 9.85 0.47 2.91e-20 Gastritis; LUSC cis rs9807989 0.507 rs4851579 chr2:103028984 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.14e-12 Asthma; LUSC cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg00071950 chr4:10020882 SLC2A9 0.65 10.83 0.51 1.26e-23 Bone mineral density; LUSC cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.87 -0.35 3.23e-11 Menarche (age at onset); LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.75e-17 Prudent dietary pattern; LUSC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12667521 chr19:29218732 NA 0.58 8.62 0.43 2.75e-16 Methadone dose in opioid dependence; LUSC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg11764359 chr7:65958608 NA -0.7 -10.7 -0.51 3.47e-23 Aortic root size; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg05623727 chr3:50126028 RBM5 0.34 6.36 0.33 6.74e-10 Body mass index; LUSC cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg05855489 chr10:104503620 C10orf26 0.59 9.38 0.46 1.01e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.49 -7.39 -0.37 1.2e-12 Menarche (age at onset); LUSC cis rs259282 0.562 rs28505804 chr19:33110047 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.63 9.38 0.46 1.05e-18 Schizophrenia; LUSC cis rs2153904 0.590 rs823106 chr1:205656453 G/C cg23034840 chr1:205782522 SLC41A1 0.65 7.05 0.36 1.02e-11 Prostate-specific antigen levels; LUSC cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22496380 chr5:211416 CCDC127 -0.87 -9.49 -0.46 4.54e-19 Breast cancer; LUSC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg22963979 chr7:1858916 MAD1L1 -0.43 -6.39 -0.33 5.59e-10 Schizophrenia; LUSC cis rs7582180 0.629 rs4851294 chr2:100941109 C/T cg12002119 chr2:101014098 CHST10 0.35 5.86 0.31 1.1e-8 Intelligence (multi-trait analysis); LUSC cis rs367943 0.688 rs10063452 chr5:112734165 C/T cg12552261 chr5:112820674 MCC 0.35 5.78 0.3 1.7e-8 Type 2 diabetes; LUSC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg03188948 chr7:1209495 NA 0.45 6.07 0.32 3.51e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.64 0.47 1.44e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9644630 1.000 rs9644630 chr8:19370598 C/T cg01280390 chr8:19363452 CSGALNACT1 0.35 6.42 0.33 4.79e-10 Oropharynx cancer; LUSC trans rs4927850 1.000 rs10881564 chr3:195750326 C/T cg16724585 chr3:197361211 NA -0.58 -8.18 -0.41 6.01e-15 Pancreatic cancer; LUSC cis rs9790314 0.747 rs6789244 chr3:160866230 A/C cg03342759 chr3:160939853 NMD3 -0.43 -7.31 -0.37 2.04e-12 Morning vs. evening chronotype; LUSC cis rs754466 0.580 rs2579176 chr10:79529350 A/G cg17075019 chr10:79541650 NA -0.76 -12.21 -0.56 1.37e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg03433033 chr1:76189801 ACADM -0.71 -9.73 -0.47 7.58e-20 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8014204 0.748 rs12889277 chr14:75229376 A/T cg06637938 chr14:75390232 RPS6KL1 0.64 10.18 0.49 2.25e-21 Caffeine consumption; LUSC cis rs4423214 0.569 rs12806918 chr11:71119018 G/T cg05163923 chr11:71159392 DHCR7 0.52 7.7 0.39 1.59e-13 Vitamin D levels; LUSC cis rs6840360 0.593 rs10016160 chr4:152693998 A/G cg22705602 chr4:152727874 NA -0.39 -8.55 -0.42 4.45e-16 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.79 0.47 4.5e-20 Bipolar disorder; LUSC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg05368731 chr17:41323189 NBR1 0.91 15.88 0.66 1.03e-42 Menopause (age at onset); LUSC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg13206674 chr6:150067644 NUP43 0.57 8.82 0.43 6.37e-17 Lung cancer; LUSC cis rs6740322 0.841 rs10211126 chr2:43551416 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.48 -0.38 6.54e-13 Coronary artery disease; LUSC cis rs2115536 0.935 rs11854390 chr15:80224817 C/T cg00225070 chr15:80189496 MTHFS 0.6 8.99 0.44 1.89e-17 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs10506458 0.915 rs1463821 chr12:63402875 C/G cg22491629 chr6:157744540 C6orf35 0.92 10.65 0.5 5.23e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs6977660 0.607 rs12113916 chr7:19781424 G/T cg05791153 chr7:19748676 TWISTNB 0.76 7.51 0.38 5.62e-13 Thyroid stimulating hormone; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg27094323 chr7:1216898 NA -0.46 -7.86 -0.39 5.47e-14 Longevity;Endometriosis; LUSC cis rs13089785 1.000 rs13081955 chr3:123600144 A/G cg02012769 chr3:123398346 MYLK 0.32 5.91 0.31 8.64e-9 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg11766577 chr21:47581405 C21orf56 -0.54 -8.39 -0.42 1.43e-15 Testicular germ cell tumor; LUSC cis rs7208859 0.573 rs7223803 chr17:29077193 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg23131131 chr22:24373011 LOC391322 -0.49 -6.97 -0.36 1.66e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9928842 1.000 rs9928842 chr16:75242867 T/C cg09066997 chr16:75300724 BCAR1 0.54 6.51 0.34 2.79e-10 Alcoholic chronic pancreatitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10433231 chr8:29940842 TMEM66 -0.42 -6.25 -0.32 1.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg01503450 chr10:980765 NA -0.4 -5.85 -0.3 1.15e-8 Eosinophil percentage of granulocytes; LUSC cis rs1372520 0.577 rs2737021 chr4:90739992 T/A cg01966878 chr4:90757139 SNCA -0.4 -5.78 -0.3 1.73e-8 Neuroticism; LUSC cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.47e-30 Motion sickness; LUSC trans rs9944715 1.000 rs9944767 chr18:43831057 A/G cg01718231 chr17:29326311 RNF135 0.51 7.19 0.37 4.33e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs6964587 0.967 rs10953065 chr7:91808915 A/G cg17063962 chr7:91808500 NA -0.6 -9.13 -0.45 6.61e-18 Breast cancer; LUSC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg10053473 chr17:62856997 LRRC37A3 0.68 10.88 0.51 8.2e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg07741184 chr6:167504864 NA -0.34 -5.94 -0.31 7.23e-9 Crohn's disease; LUSC cis rs3755132 0.929 rs61314003 chr2:15748524 A/G cg12888861 chr2:15731646 DDX1 0.5 7.3 0.37 2.16e-12 Wilms tumor; LUSC cis rs6430585 0.528 rs12474975 chr2:136702118 A/T cg07169764 chr2:136633963 MCM6 1.13 17.44 0.69 6.81e-49 Corneal structure; LUSC cis rs500891 0.533 rs3757009 chr6:84131194 G/A cg08257003 chr6:84140564 ME1 0.36 8.7 0.43 1.51e-16 Platelet-derived growth factor BB levels; LUSC cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.46 0.38 7.75e-13 Motion sickness; LUSC cis rs72781680 1.000 rs72781648 chr2:24210333 T/C cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs11630290 0.589 rs2120251 chr15:64168772 T/C cg12036633 chr15:63758958 NA 0.48 5.98 0.31 5.6e-9 Iris characteristics; LUSC cis rs10761482 0.813 rs10821735 chr10:62104980 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.92 -0.35 2.28e-11 Menopause (age at onset); LUSC cis rs11785400 0.612 rs10110864 chr8:143750072 A/G cg24634471 chr8:143751801 JRK 0.5 7.19 0.37 4.17e-12 Schizophrenia; LUSC trans rs9291683 0.609 rs36084205 chr4:10028678 A/C cg26043149 chr18:55253948 FECH 0.51 7.52 0.38 5.09e-13 Bone mineral density; LUSC cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.71 -0.43 1.4e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg24549020 chr5:56110836 MAP3K1 0.47 5.8 0.3 1.58e-8 Initial pursuit acceleration; LUSC cis rs782590 0.935 rs782568 chr2:55881538 T/C cg03859395 chr2:55845619 SMEK2 0.88 16.5 0.67 3.62e-45 Metabolic syndrome; LUSC cis rs748404 0.697 rs574065 chr15:43550655 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.42 -6.06 -0.31 3.76e-9 Lung cancer; LUSC trans rs2797160 1.000 rs6933471 chr6:126017029 T/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.85 0.35 3.56e-11 Endometrial cancer; LUSC cis rs472402 0.560 rs6874005 chr5:6624371 C/T cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.51 -7.32 -0.37 1.87e-12 Response to amphetamines; LUSC cis rs61935443 0.720 rs10859785 chr12:95295081 A/T cg21533806 chr12:95267307 NA 0.5 6.19 0.32 1.79e-9 Schizophrenia; LUSC trans rs6076960 0.681 rs4487157 chr20:6249581 G/A cg17788362 chr6:86352627 SYNCRIP 0.44 6.29 0.33 9.71e-10 Smooth-surface caries; LUSC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg06873352 chr17:61820015 STRADA 0.55 8.56 0.42 4.22e-16 Height; LUSC cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC trans rs34421088 0.506 rs4841519 chr8:11146228 A/T cg15556689 chr8:8085844 FLJ10661 0.44 6.85 0.35 3.56e-11 Neuroticism; LUSC cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.02 0.58 1.28e-31 Chronic sinus infection; LUSC cis rs2227564 0.729 rs2633304 chr10:75650650 T/C cg23231163 chr10:75533350 FUT11 -0.43 -5.88 -0.31 9.97e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg18252515 chr7:66147081 NA -1.23 -13.29 -0.59 1.17e-32 Diabetic kidney disease; LUSC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg09034736 chr1:150693464 HORMAD1 0.49 7.11 0.36 7.09e-12 Tonsillectomy; LUSC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.66 8.39 0.42 1.4e-15 Lung function (FEV1/FVC); LUSC trans rs11098499 0.866 rs6847778 chr4:120293582 A/G cg25214090 chr10:38739885 LOC399744 0.52 7.65 0.39 2.22e-13 Corneal astigmatism; LUSC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs1559088 0.847 rs8110181 chr19:33605939 G/A cg03563238 chr19:33554763 RHPN2 -0.4 -6.26 -0.32 1.16e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg15704280 chr7:45808275 SEPT13 0.69 7.64 0.39 2.3e-13 Axial length; LUSC cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.05e-14 Crohn's disease; LUSC trans rs2204008 0.837 rs11183232 chr12:37941053 A/G cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.26e-10 Bladder cancer; LUSC cis rs11785400 0.793 rs750530 chr8:143744931 G/A cg10596483 chr8:143751796 JRK 0.52 7.56 0.38 3.9e-13 Schizophrenia; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg26338869 chr17:61819248 STRADA 0.42 6.23 0.32 1.44e-9 Prudent dietary pattern; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26067897 chr5:41904347 C5orf51 0.42 6.3 0.33 9.63e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs35000415 0.938 rs12706861 chr7:128616582 C/T cg19972273 chr7:128594194 NA 0.67 6.84 0.35 3.77e-11 Systemic lupus erythematosus; LUSC cis rs796364 0.806 rs10931887 chr2:200968905 G/A cg23649088 chr2:200775458 C2orf69 -0.53 -6.46 -0.33 3.79e-10 Schizophrenia; LUSC cis rs6542838 0.641 rs12712042 chr2:99534401 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.48 -0.38 6.82e-13 Fear of minor pain; LUSC cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.38 -0.42 1.47e-15 Schizophrenia; LUSC cis rs73206853 0.841 rs3026483 chr12:110780905 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs61931739 0.782 rs3903201 chr12:34248275 G/A cg26384229 chr12:38710491 ALG10B 0.55 8.74 0.43 1.16e-16 Morning vs. evening chronotype; LUSC cis rs2425143 0.730 rs6579259 chr20:34462550 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.67 -0.3 3.14e-8 Blood protein levels; LUSC cis rs9399135 0.967 rs12661423 chr6:135349570 C/T cg22676075 chr6:135203613 NA 0.45 7.22 0.37 3.44e-12 Red blood cell count; LUSC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.78e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs911119 0.955 rs17751897 chr20:23592714 T/C cg16589663 chr20:23618590 CST3 0.57 6.79 0.35 5.04e-11 Chronic kidney disease; LUSC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.68 0.5 4.11e-23 Hip circumference adjusted for BMI; LUSC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.77 13.52 0.59 1.6e-33 Menarche (age at onset); LUSC cis rs939658 0.776 rs68147688 chr15:79443848 G/A cg17916960 chr15:79447300 NA -0.54 -10.92 -0.51 5.97e-24 Refractive error; LUSC cis rs10992471 0.528 rs6479423 chr9:95265580 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.2 -0.32 1.69e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9399401 0.626 rs7776356 chr6:142777029 A/G cg03128060 chr6:142623767 GPR126 0.53 9.12 0.45 6.95e-18 Chronic obstructive pulmonary disease; LUSC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg24531977 chr5:56204891 C5orf35 -1.06 -15.2 -0.64 5.19e-40 Initial pursuit acceleration; LUSC cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg03526776 chr6:41159608 TREML2 0.47 8.27 0.41 3.31e-15 Alzheimer's disease (late onset); LUSC cis rs1044826 0.647 rs4683463 chr3:139196946 T/G cg15131784 chr3:139108705 COPB2 0.4 6.38 0.33 5.77e-10 Obesity-related traits; LUSC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg21251018 chr6:28226885 NKAPL 0.32 5.76 0.3 1.92e-8 Cardiac Troponin-T levels; LUSC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg04369109 chr6:150039330 LATS1 -0.57 -8.41 -0.42 1.21e-15 Lung cancer; LUSC cis rs1028488 0.511 rs6934743 chr6:170696385 A/G cg20370364 chr6:170703943 FAM120B -0.48 -7.17 -0.37 4.98e-12 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs6714710 0.603 rs12988571 chr2:98405695 C/T cg26665480 chr2:98280029 ACTR1B 0.61 8.97 0.44 2.12e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.13e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.754 rs702324 chr6:146008793 A/G cg23711669 chr6:146136114 FBXO30 -0.52 -8.06 -0.4 1.38e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 9.65 0.47 1.4e-19 Menopause (age at onset); LUSC cis rs138918 0.772 rs138932 chr22:43565443 C/T cg08909806 chr22:43548696 TSPO 0.36 6.19 0.32 1.8e-9 Monocyte count; LUSC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg03732007 chr1:2071316 PRKCZ -0.54 -9.54 -0.46 3.16e-19 Height; LUSC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg02931644 chr1:25747376 RHCE 0.35 6.37 0.33 6.26e-10 Erythrocyte sedimentation rate; LUSC trans rs2243480 1.000 rs34193460 chr7:65393110 A/G cg10756647 chr7:56101905 PSPH 0.89 8.61 0.43 2.86e-16 Diabetic kidney disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20066120 chr12:120554733 RAB35 -0.42 -6.04 -0.31 4.1e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg04944784 chr2:26401820 FAM59B -0.72 -9.92 -0.48 1.68e-20 Gut microbiome composition (summer); LUSC trans rs7824557 0.527 rs2572376 chr8:11237756 C/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.47 -0.38 6.92e-13 Retinal vascular caliber; LUSC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg02951883 chr7:2050386 MAD1L1 -0.57 -10.86 -0.51 1.02e-23 Bipolar disorder and schizophrenia; LUSC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.2 0.64 5.07e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.51 0.42 6.06e-16 Prudent dietary pattern; LUSC cis rs4704187 0.687 rs6898116 chr5:74486778 T/G cg03227963 chr5:74354835 NA 0.3 6.54 0.34 2.32e-10 Response to amphetamines; LUSC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4478137 0.931 rs12509756 chr4:164237464 A/T cg06758707 chr4:164254230 NPY1R 0.66 10.1 0.48 4.13e-21 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg04117972 chr1:227635322 NA 0.61 6.88 0.35 2.9e-11 Major depressive disorder; LUSC cis rs8078723 0.966 rs7021 chr17:38153875 T/A cg17467752 chr17:38218738 THRA 0.77 12.47 0.56 1.47e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs6598955 0.543 rs60676610 chr1:26543421 G/C cg04990556 chr1:26633338 UBXN11 0.85 11.14 0.52 9.76e-25 Obesity-related traits; LUSC cis rs9837602 1.000 rs35669453 chr3:99766063 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.11 0.32 2.75e-9 Breast cancer; LUSC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg10057126 chr4:77819792 ANKRD56 0.44 6.46 0.33 3.72e-10 Emphysema distribution in smoking; LUSC cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg08859206 chr1:53392774 SCP2 -0.41 -6.71 -0.34 8.17e-11 Monocyte count; LUSC trans rs7939886 0.920 rs11231901 chr11:55811529 A/G cg03929089 chr4:120376271 NA 0.77 6.36 0.33 6.46e-10 Myopia (pathological); LUSC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg20503657 chr10:835505 NA -0.94 -14.06 -0.61 1.39e-35 Eosinophil percentage of granulocytes; LUSC cis rs13315871 0.929 rs77487951 chr3:58290892 G/A cg12435725 chr3:58293450 RPP14 -0.77 -7.45 -0.38 8.27e-13 Cholesterol, total; LUSC cis rs6750047 0.585 rs62136319 chr2:38272950 G/A cg07380506 chr2:38303506 CYP1B1 0.44 6.07 0.32 3.45e-9 Cutaneous malignant melanoma;Melanoma; LUSC trans rs11610422 1.000 rs12824459 chr12:31414435 C/T cg02734259 chr12:9559402 NA -0.6 -6.39 -0.33 5.69e-10 Coronary artery disease; LUSC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.11 -0.36 7.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg24450063 chr1:156163899 SLC25A44 1.09 23.38 0.79 2.65e-72 Testicular germ cell tumor; LUSC cis rs1595825 0.891 rs78835808 chr2:198669110 G/A cg00982548 chr2:198649783 BOLL -0.6 -7.29 -0.37 2.2e-12 Ulcerative colitis; LUSC trans rs61931739 0.649 rs864174 chr12:33729352 C/A cg26384229 chr12:38710491 ALG10B 0.42 6.07 0.32 3.51e-9 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs741013 0.502 rs13322726 chr3:64335926 C/T cg22101924 chr15:79574964 ANKRD34C 0.4 5.94 0.31 7.06e-9 Coronary artery calcification; LUSC cis rs2708377 0.789 rs3911150 chr12:11202248 A/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.8 -8.03 -0.4 1.74e-14 Bitter taste perception; LUSC cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg23788917 chr6:8435910 SLC35B3 0.5 7.32 0.37 1.83e-12 Motion sickness; LUSC cis rs11792861 0.566 rs6477687 chr9:111837791 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.41 -6.89 -0.35 2.71e-11 Menarche (age at onset); LUSC trans rs8002861 0.781 rs3816311 chr13:44453783 G/A cg12856521 chr11:46389249 DGKZ 0.44 6.82 0.35 4.34e-11 Leprosy; LUSC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg24549020 chr5:56110836 MAP3K1 0.49 5.99 0.31 5.58e-9 Initial pursuit acceleration; LUSC cis rs7833787 1.000 rs6586778 chr8:18706170 G/C cg17701159 chr8:18705777 PSD3 -0.38 -6.21 -0.32 1.56e-9 Obesity-related traits; LUSC cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg17366294 chr4:99064904 C4orf37 0.59 10.5 0.5 1.81e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs6545883 0.894 rs35292974 chr2:61522047 T/C cg15711740 chr2:61764176 XPO1 0.47 7.43 0.38 9.45e-13 Tuberculosis; LUSC cis rs17155006 0.655 rs433534 chr7:107727440 A/G cg05962710 chr7:107745446 LAMB4 -0.33 -5.84 -0.3 1.27e-8 Pneumococcal bacteremia; LUSC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg16797656 chr11:68205561 LRP5 0.4 7.08 0.36 8.41e-12 Total body bone mineral density; LUSC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.63 -8.62 -0.43 2.74e-16 Body mass index (adult); LUSC cis rs950169 0.763 rs35372971 chr15:84941795 G/A cg17173187 chr15:85201210 NMB 0.37 6.52 0.34 2.61e-10 Schizophrenia; LUSC cis rs7937682 0.924 rs10891288 chr11:111552053 G/T cg19812747 chr11:111475976 SIK2 0.47 6.62 0.34 1.39e-10 Primary sclerosing cholangitis; LUSC trans rs7829975 0.714 rs7823757 chr8:8670177 T/A cg21775007 chr8:11205619 TDH 0.43 6.18 0.32 1.89e-9 Mood instability; LUSC cis rs9815354 0.812 rs10510731 chr3:41853310 C/T cg03022575 chr3:42003672 ULK4 0.85 8.74 0.43 1.19e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg06238570 chr21:40685208 BRWD1 -0.58 -8.99 -0.44 1.93e-17 Menarche (age at onset); LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.74 0.39 1.15e-13 Prudent dietary pattern; LUSC trans rs2689154 1.000 rs2689154 chr1:238908353 C/G cg14385985 chr10:70587144 STOX1 -0.47 -6.22 -0.32 1.46e-9 Pancreatic cancer; LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg02475777 chr4:1388615 CRIPAK 0.44 6.56 0.34 2.1e-10 Obesity-related traits; LUSC cis rs7512552 0.839 rs698919 chr1:150387000 A/G cg15654264 chr1:150340011 RPRD2 0.61 10.15 0.49 2.84e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.07 0.32 3.48e-9 Lymphocyte counts; LUSC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg20135002 chr11:47629003 NA -0.5 -7.78 -0.39 9.29e-14 Subjective well-being; LUSC cis rs7267979 1.000 rs4815407 chr20:25341478 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.1 -0.74 1.91e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.84 12.26 0.56 8.63e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6089584 0.566 rs55881457 chr20:60608424 G/A cg24733560 chr20:60626293 TAF4 0.44 8.04 0.4 1.56e-14 Body mass index; LUSC cis rs4285028 0.747 rs7648340 chr3:121426188 G/C cg11130432 chr3:121712080 ILDR1 -0.53 -7.84 -0.39 6.07e-14 Multiple sclerosis; LUSC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg07424592 chr7:64974309 NA 0.67 5.9 0.31 9.11e-9 Diabetic kidney disease; LUSC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg13393036 chr8:95962371 TP53INP1 0.35 6.47 0.33 3.53e-10 Type 2 diabetes; LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.24 0.32 1.32e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18295930 chr20:46130624 NCOA3 0.45 6.0 0.31 5.09e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72960926 0.744 rs1552568 chr6:75035349 G/T cg03266952 chr6:74778945 NA -0.66 -6.16 -0.32 2.1e-9 Metabolite levels (MHPG); LUSC cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg08917208 chr2:24149416 ATAD2B 0.55 6.25 0.32 1.24e-9 Lymphocyte counts; LUSC cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.6 -0.46 2.04e-19 Chronic sinus infection; LUSC cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg06064525 chr11:970664 AP2A2 -0.49 -10.81 -0.51 1.5e-23 Alzheimer's disease (late onset); LUSC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg13175981 chr1:150552382 MCL1 -0.41 -5.66 -0.3 3.35e-8 Tonsillectomy; LUSC cis rs12594515 0.506 rs74199860 chr15:45989190 C/T cg06207120 chr15:45996521 NA 0.39 6.09 0.32 3.07e-9 Waist circumference;Weight; LUSC cis rs3960554 0.808 rs4728587 chr7:75803132 C/T cg17325771 chr7:75508891 RHBDD2 -0.42 -5.92 -0.31 7.79e-9 Eotaxin levels; LUSC cis rs1007190 0.881 rs9914884 chr17:42955589 T/C cg15406952 chr17:42872593 NA 0.55 5.68 0.3 2.97e-8 DNA methylation (variation); LUSC trans rs4674124 1.000 rs1179689 chr2:217763115 A/G cg18563886 chr10:135203102 PAOX -0.42 -5.97 -0.31 5.95e-9 Breast cancer; LUSC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg18240062 chr17:79603768 NPLOC4 0.7 13.1 0.58 6.34e-32 Eye color traits; LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg14552801 chr7:65878734 NA 0.37 5.86 0.31 1.12e-8 Aortic root size; LUSC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg14668632 chr7:2872130 GNA12 -0.48 -7.4 -0.38 1.1e-12 Height; LUSC trans rs656319 0.513 rs6985941 chr8:9983179 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.34 -0.33 7.27e-10 Myopia (pathological); LUSC cis rs1011108 0.518 rs935172 chr2:26804247 A/G cg18742855 chr2:26800399 C2orf70 -0.41 -8.1 -0.41 1.03e-14 Periodontal microbiota; LUSC trans rs800082 1.000 rs1961653 chr3:144286098 C/T cg24215973 chr2:240111563 HDAC4 -0.47 -7.2 -0.37 3.93e-12 Smoking behavior; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg15147215 chr3:52552868 STAB1 -0.33 -5.86 -0.31 1.09e-8 Bipolar disorder; LUSC cis rs3847687 0.966 rs3847689 chr12:131525534 T/G cg13586425 chr12:131519906 GPR133 -0.25 -5.8 -0.3 1.51e-8 Longevity; LUSC cis rs6736093 0.966 rs13020304 chr2:112741535 A/G cg12686935 chr2:112915763 FBLN7 -0.37 -6.03 -0.31 4.39e-9 Coronary artery disease; LUSC cis rs2446066 0.872 rs10876451 chr12:53813424 A/C cg20730629 chr12:53886622 MAP3K12 -0.4 -5.72 -0.3 2.38e-8 Red blood cell count; LUSC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.5 0.5 1.85e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4285028 0.948 rs76593525 chr3:121690477 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.64 -0.47 1.43e-19 Multiple sclerosis; LUSC trans rs9329221 0.537 rs6601414 chr8:9976748 G/A cg15556689 chr8:8085844 FLJ10661 0.52 7.93 0.4 3.38e-14 Neuroticism; LUSC cis rs7246967 0.611 rs8104327 chr19:22867159 C/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs1355223 0.506 rs7130678 chr11:34869181 A/G cg11058730 chr11:34937778 PDHX;APIP -0.52 -7.34 -0.37 1.6e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs8044995 0.517 rs2863973 chr16:68409435 A/C cg09835421 chr16:68378352 PRMT7 -0.56 -6.78 -0.35 5.6e-11 Schizophrenia; LUSC cis rs7089973 0.604 rs2420065 chr10:116583753 A/G cg25233709 chr10:116636983 FAM160B1 0.38 6.63 0.34 1.38e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7909074 1.000 rs10736831 chr10:45402311 G/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.66 -0.43 2.07e-16 Mean corpuscular volume; LUSC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg23719950 chr11:63933701 MACROD1 -0.63 -7.68 -0.39 1.82e-13 Mean platelet volume; LUSC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg11764359 chr7:65958608 NA 0.68 10.89 0.51 7.94e-24 Aortic root size; LUSC cis rs72781680 1.000 rs72781653 chr2:24215633 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.87e-9 Lymphocyte counts; LUSC cis rs17818399 0.926 rs13032670 chr2:46830794 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.48 -6.26 -0.32 1.18e-9 Height; LUSC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.51 -0.34 2.74e-10 Neuroticism; LUSC cis rs2235544 0.565 rs676562 chr1:54468638 C/G cg25741118 chr1:54482237 LDLRAD1 0.28 5.99 0.31 5.28e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs2637266 0.626 rs846603 chr10:78570793 A/G cg18941641 chr10:78392320 NA -0.37 -6.78 -0.35 5.3e-11 Pulmonary function; LUSC cis rs7511006 0.895 rs5771270 chr22:50682865 G/A cg16473166 chr22:50639996 SELO 0.59 7.77 0.39 9.49e-14 Obesity-related traits; LUSC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg11644478 chr21:40555479 PSMG1 0.76 9.56 0.46 2.66e-19 Cognitive function; LUSC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg08773314 chr2:239334832 ASB1 0.41 9.0 0.44 1.69e-17 Multiple system atrophy; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg27170947 chr2:26402098 FAM59B -0.65 -10.15 -0.49 2.88e-21 Gut microbiome composition (summer); LUSC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.34e-12 Tonsillectomy; LUSC cis rs1908814 0.516 rs13281315 chr8:11794855 C/G cg21775007 chr8:11205619 TDH 0.47 6.66 0.34 1.11e-10 Neuroticism; LUSC cis rs7267979 1.000 rs4815426 chr20:25405186 A/C cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg11244672 chr19:19639970 YJEFN3 0.59 7.24 0.37 3.17e-12 Bipolar disorder; LUSC cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg13010199 chr12:38710504 ALG10B 0.65 9.81 0.47 3.95e-20 Bladder cancer; LUSC cis rs9815354 0.812 rs56332587 chr3:42012714 T/C cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.5e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg06238570 chr21:40685208 BRWD1 0.52 7.94 0.4 3.04e-14 Cognitive function; LUSC cis rs2050392 0.861 rs1042058 chr10:30728101 T/C cg18806716 chr10:30721971 MAP3K8 -0.48 -7.93 -0.4 3.24e-14 Inflammatory bowel disease; LUSC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs6722750 0.846 rs13394665 chr2:64391431 A/C cg22352474 chr2:64371530 PELI1 -0.62 -10.03 -0.48 7.44e-21 Neuroticism; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg16606324 chr3:10149918 C3orf24 0.65 9.18 0.45 4.63e-18 Alzheimer's disease; LUSC cis rs4319547 0.656 rs10846664 chr12:122823777 C/T cg05707623 chr12:122985044 ZCCHC8 0.68 8.22 0.41 4.61e-15 Body mass index; LUSC cis rs6693567 0.565 rs834225 chr1:150300727 T/C cg15654264 chr1:150340011 RPRD2 0.46 7.35 0.37 1.5e-12 Migraine; LUSC cis rs9815354 0.812 rs17215883 chr3:41841873 C/T cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg15147215 chr3:52552868 STAB1 -0.3 -5.95 -0.31 6.85e-9 Bipolar disorder; LUSC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg08439880 chr3:133502540 NA 0.39 7.34 0.37 1.65e-12 Iron status biomarkers; LUSC trans rs10435719 0.834 rs11250176 chr8:11792816 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.61e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs2485376 1.000 rs772021 chr10:104036449 A/T cg15216925 chr5:179921655 CNOT6 0.35 5.98 0.31 5.79e-9 QT interval; LUSC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg09365446 chr1:150670422 GOLPH3L 0.47 7.02 0.36 1.24e-11 Melanoma; LUSC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg11764359 chr7:65958608 NA -0.7 -10.94 -0.51 5.32e-24 Aortic root size; LUSC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.43 6.12 0.32 2.58e-9 Breast cancer; LUSC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg15445000 chr17:37608096 MED1 0.39 6.68 0.34 9.76e-11 Glomerular filtration rate (creatinine); LUSC cis rs10751667 0.666 rs11246358 chr11:967349 G/A ch.11.42038R chr11:967971 AP2A2 0.42 6.13 0.32 2.48e-9 Alzheimer's disease (late onset); LUSC trans rs7615952 0.611 rs7632305 chr3:125634767 C/T cg07211511 chr3:129823064 LOC729375 -1.05 -12.96 -0.58 2.17e-31 Blood pressure (smoking interaction); LUSC cis rs870825 0.860 rs72703529 chr4:185607351 T/C cg04058563 chr4:185651563 MLF1IP 0.76 10.13 0.48 3.2e-21 Blood protein levels; LUSC cis rs4727027 0.736 rs12704084 chr7:148915050 C/G cg23583168 chr7:148888333 NA -0.86 -15.58 -0.65 1.64e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7192380 0.965 rs3848278 chr16:69640867 T/C cg26679644 chr16:69762563 NA 0.35 6.2 0.32 1.7e-9 Sjögren's syndrome; LUSC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg26335602 chr6:28129616 ZNF389 0.46 6.21 0.32 1.6e-9 Parkinson's disease; LUSC cis rs61990749 0.597 rs17106157 chr14:78146878 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.41 -0.33 4.99e-10 Fibroblast growth factor basic levels; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg07961406 chr16:67193646 FBXL8;TRADD 0.36 6.11 0.32 2.78e-9 Metabolite levels (Pyroglutamine); LUSC cis rs7580658 0.963 rs12479003 chr2:128118553 C/T cg09760422 chr2:128146352 NA -0.33 -7.25 -0.37 2.91e-12 Protein C levels; LUSC cis rs9311676 0.609 rs62258077 chr3:58363371 T/C cg13750441 chr3:58318267 PXK 0.34 6.65 0.34 1.22e-10 Systemic lupus erythematosus; LUSC cis rs950027 0.620 rs1719245 chr15:45623782 T/C cg09092052 chr15:45571596 NA -0.41 -5.68 -0.3 2.87e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs1055129 0.560 rs56248937 chr17:73915153 T/A cg08125733 chr17:73851984 WBP2 0.49 6.92 0.35 2.38e-11 White matter hyperintensity burden; LUSC cis rs9326248 0.581 rs11216267 chr11:116952392 C/T cg01368799 chr11:117014884 PAFAH1B2 0.59 9.02 0.44 1.48e-17 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25245506 chr22:39052398 LOC646851;CBY1 -0.45 -6.59 -0.34 1.73e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg18904891 chr8:8559673 CLDN23 0.6 8.24 0.41 3.84e-15 Obesity-related traits; LUSC cis rs4589502 1.000 rs4589502 chr15:67155069 C/T cg12317470 chr15:67143691 NA 0.6 6.27 0.32 1.1e-9 Lung cancer (smoking interaction); LUSC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg25319279 chr11:5960081 NA -0.47 -6.59 -0.34 1.76e-10 DNA methylation (variation); LUSC cis rs12908161 0.959 rs35557864 chr15:85331629 A/G cg12863693 chr15:85201151 NMB 0.4 8.02 0.4 1.79e-14 Schizophrenia; LUSC cis rs4780401 0.609 rs9924522 chr16:11816852 C/A cg01061890 chr16:11836724 TXNDC11 -0.56 -8.58 -0.42 3.71e-16 Rheumatoid arthritis; LUSC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.74 -0.3 2.14e-8 Depression; LUSC cis rs6456156 0.603 rs2345754 chr6:167484361 T/C cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs7011049 1.000 rs117708010 chr8:53844026 G/A cg26025543 chr8:53854495 NA 0.53 6.35 0.33 7.13e-10 Systolic blood pressure; LUSC cis rs9393777 0.588 rs6926677 chr6:26478825 G/C cg12292205 chr6:26970375 C6orf41 -0.6 -7.42 -0.38 9.95e-13 Intelligence (multi-trait analysis); LUSC cis rs7523273 0.606 rs859705 chr1:207959665 A/G cg22525895 chr1:207977042 MIR29B2 0.41 6.67 0.34 1.04e-10 Schizophrenia; LUSC cis rs9399135 0.838 rs4896126 chr6:135342786 C/A cg24558204 chr6:135376177 HBS1L 0.59 9.14 0.45 6.29e-18 Red blood cell count; LUSC cis rs11031096 0.754 rs3817657 chr11:4142592 T/C cg18678763 chr11:4115507 RRM1 -0.49 -7.24 -0.37 3.12e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg20295408 chr7:1910781 MAD1L1 -0.46 -6.33 -0.33 7.94e-10 Bipolar disorder and schizophrenia; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg19318889 chr4:1322082 MAEA 0.81 14.74 0.63 3.17e-38 Longevity; LUSC cis rs1728785 1.000 rs1615609 chr16:68596401 C/A cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.45e-10 Ulcerative colitis; LUSC cis rs2273669 0.667 rs117941557 chr6:109298135 G/A cg05315195 chr6:109294784 ARMC2 -0.58 -6.47 -0.33 3.39e-10 Prostate cancer; LUSC cis rs7909074 0.651 rs10900127 chr10:45390103 C/A cg05187965 chr10:45406764 TMEM72 -0.31 -6.93 -0.35 2.21e-11 Mean corpuscular volume; LUSC cis rs6063312 1.000 rs6063312 chr20:47343059 G/T cg18078177 chr20:47281410 PREX1 0.6 7.21 0.37 3.83e-12 Tonometry; LUSC cis rs4423214 0.879 rs12803256 chr11:71132868 A/G cg05163923 chr11:71159392 DHCR7 0.69 10.11 0.48 3.72e-21 Vitamin D levels; LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg08949735 chr16:89699720 DPEP1 -0.24 -5.91 -0.31 8.29e-9 Vitiligo; LUSC cis rs13064411 0.696 rs6438161 chr3:113227637 G/A cg18753928 chr3:113234510 CCDC52 -0.51 -7.93 -0.4 3.26e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg11752832 chr7:134001865 SLC35B4 0.6 9.37 0.46 1.09e-18 Mean platelet volume; LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.86 -0.31 1.11e-8 Platelet count; LUSC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.21e-12 Schizophrenia; LUSC cis rs1728785 1.000 rs864741 chr16:68576577 C/T cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg15145296 chr3:125709740 NA -0.56 -6.27 -0.32 1.15e-9 Blood pressure (smoking interaction); LUSC cis rs77741769 1.000 rs77741769 chr12:121363835 C/T cg02403541 chr12:121454288 C12orf43 0.5 7.31 0.37 2.02e-12 Mean corpuscular volume; LUSC cis rs7577696 0.597 rs34197800 chr2:32389646 C/A cg02381751 chr2:32503542 YIPF4 -0.52 -6.91 -0.35 2.46e-11 Inflammatory biomarkers; LUSC cis rs12286929 0.589 rs4938190 chr11:115087750 C/T cg04055981 chr11:115044050 NA 0.39 6.81 0.35 4.44e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg20607798 chr8:58055168 NA 0.52 5.7 0.3 2.57e-8 Developmental language disorder (linguistic errors); LUSC trans rs12579753 0.871 rs10862363 chr12:82201254 T/A cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs701145 1.000 rs701145 chr3:154054799 T/C cg17054900 chr3:154042577 DHX36 0.81 8.69 0.43 1.7e-16 Coronary artery disease; LUSC cis rs983392 0.805 rs2081545 chr11:59958380 C/A cg24026212 chr11:59952134 MS4A6A -0.37 -6.28 -0.33 1.05e-9 Alzheimer's disease (late onset); LUSC cis rs61931739 0.817 rs10743841 chr12:34252870 T/C cg06521331 chr12:34319734 NA -0.39 -6.78 -0.35 5.43e-11 Morning vs. evening chronotype; LUSC cis rs3774830 0.714 rs55816120 chr4:5463350 C/T cg26943120 chr4:5472116 STK32B 0.3 5.93 0.31 7.39e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg13393036 chr8:95962371 TP53INP1 -0.46 -9.49 -0.46 4.47e-19 Type 2 diabetes; LUSC cis rs6500395 0.963 rs4785248 chr16:48687947 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7089973 0.604 rs61596353 chr10:116597763 T/C cg23260525 chr10:116636907 FAM160B1 0.43 9.23 0.45 3.24e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7575217 0.961 rs1192788 chr2:101782978 C/T cg23907051 chr2:101730305 TBC1D8 -0.27 -6.61 -0.34 1.5e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs71403859 0.730 rs12931191 chr16:71621373 A/T cg08717414 chr16:71523259 ZNF19 0.72 7.87 0.4 4.83e-14 Post bronchodilator FEV1; LUSC cis rs2629540 0.924 rs2629541 chr10:126425866 G/A cg08799069 chr10:126477246 METTL10 0.65 8.92 0.44 3.06e-17 Cocaine dependence; LUSC cis rs9303401 0.659 rs35539277 chr17:56853833 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.46 0.56 1.59e-29 Cognitive test performance; LUSC cis rs9911578 0.835 rs9889419 chr17:56473259 C/T cg12560992 chr17:57184187 TRIM37 0.69 12.23 0.56 1.11e-28 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.84 0.3 1.24e-8 Menopause (age at onset); LUSC trans rs4714291 0.802 rs1474870 chr6:39980359 C/T cg02267698 chr19:7991119 CTXN1 0.51 7.61 0.38 2.81e-13 Strep throat; LUSC cis rs654950 0.875 rs116747365 chr1:41994792 C/T cg06885757 chr1:42089581 HIVEP3 -0.34 -6.55 -0.34 2.24e-10 Airway imaging phenotypes; LUSC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg06718696 chr17:78121285 EIF4A3 -0.45 -6.48 -0.33 3.33e-10 Yeast infection; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg13560548 chr3:10150139 C3orf24 0.48 6.77 0.35 5.72e-11 Alzheimer's disease; LUSC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg08847533 chr14:75593920 NEK9 -0.8 -13.7 -0.6 3.38e-34 Height; LUSC cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg01579765 chr21:45077557 HSF2BP -0.47 -9.76 -0.47 6e-20 Mean corpuscular volume; LUSC cis rs6005807 0.719 rs9620810 chr22:29053727 T/C cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs652260 1.000 rs590394 chr19:7902505 C/T cg26014689 chr19:7917955 EVI5L -0.48 -8.49 -0.42 6.66e-16 Menarche (age at onset); LUSC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg14552801 chr7:65878734 NA -0.45 -6.34 -0.33 7.34e-10 Aortic root size; LUSC cis rs75804782 0.521 rs55915157 chr2:239424273 T/C cg18131467 chr2:239335373 ASB1 -0.65 -5.95 -0.31 6.71e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs2463822 1.000 rs2513071 chr11:62098387 A/C cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72799341 1.000 rs7185007 chr16:30927509 C/T cg02466173 chr16:30829666 NA -0.51 -7.79 -0.39 8.38e-14 Diastolic blood pressure; LUSC cis rs6120849 0.754 rs36003887 chr20:33589107 G/A cg24642439 chr20:33292090 TP53INP2 0.62 6.85 0.35 3.66e-11 Protein C levels; LUSC cis rs6545883 0.894 rs10496092 chr2:61524679 C/T cg15711740 chr2:61764176 XPO1 0.47 7.17 0.37 4.71e-12 Tuberculosis; LUSC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs7613875 0.620 rs17657664 chr3:50032008 T/G cg21659725 chr3:3221576 CRBN 0.53 8.42 0.42 1.11e-15 Body mass index; LUSC trans rs11992162 0.967 rs4840601 chr8:11828730 G/C cg06636001 chr8:8085503 FLJ10661 0.55 8.12 0.41 9.29e-15 Monocyte count; LUSC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg11764359 chr7:65958608 NA 0.64 9.84 0.47 3.18e-20 Aortic root size; LUSC cis rs6733011 0.531 rs13004923 chr2:99497561 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.38 -0.33 5.98e-10 Bipolar disorder; LUSC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg12311346 chr5:56204834 C5orf35 -0.6 -8.5 -0.42 6.57e-16 Coronary artery disease; LUSC cis rs10207060 0.500 rs72992164 chr2:240711780 G/A cg07506560 chr2:240697449 NA 0.47 7.27 0.37 2.59e-12 Obesity-related traits; LUSC cis rs2050392 0.929 rs10826798 chr10:30700904 G/A cg18806716 chr10:30721971 MAP3K8 0.49 7.99 0.4 2.16e-14 Inflammatory bowel disease; LUSC cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg23711669 chr6:146136114 FBXO30 0.84 15.03 0.64 2.36e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs2050392 0.767 rs2183175 chr10:30699336 A/G cg25182066 chr10:30743637 MAP3K8 0.42 6.03 0.31 4.31e-9 Inflammatory bowel disease; LUSC cis rs7819412 0.749 rs11991118 chr8:10939273 A/C cg21775007 chr8:11205619 TDH 0.44 6.5 0.33 3.01e-10 Triglycerides; LUSC cis rs77633900 0.614 rs2454453 chr15:76913976 T/A cg21673338 chr15:77095150 SCAPER -0.72 -6.99 -0.36 1.48e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs10193935 0.786 rs72796504 chr2:42406728 T/C cg27598129 chr2:42591480 NA -0.58 -7.82 -0.39 7.22e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9902453 0.868 rs7212162 chr17:28321328 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 10.81 0.51 1.47e-23 Coffee consumption (cups per day); LUSC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg25039879 chr17:56429692 SUPT4H1 0.72 9.82 0.47 3.63e-20 Cognitive test performance; LUSC cis rs28456 1 rs28456 chr11:61589481 A/G cg19610905 chr11:61596333 FADS2 -0.53 -7.96 -0.4 2.8e-14 Bipolar disorder; LUSC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg00343986 chr7:65444356 GUSB -0.38 -5.73 -0.3 2.29e-8 Aortic root size; LUSC trans rs12478296 0.591 rs7573042 chr2:242996589 A/G cg14392985 chr9:129345450 NA -0.27 -5.96 -0.31 6.52e-9 Obesity-related traits; LUSC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs2629540 0.847 rs12762597 chr10:126387043 G/A cg08799069 chr10:126477246 METTL10 0.6 7.98 0.4 2.44e-14 Cocaine dependence; LUSC cis rs8016982 0.630 rs61980900 chr14:81686436 T/C cg01989461 chr14:81687754 GTF2A1 0.72 12.99 0.58 1.62e-31 Schizophrenia; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg00431813 chr7:1051703 C7orf50 -0.44 -7.23 -0.37 3.42e-12 Longevity;Endometriosis; LUSC cis rs13256369 0.802 rs12541520 chr8:8564146 G/T cg18904891 chr8:8559673 CLDN23 0.59 8.34 0.42 2e-15 Obesity-related traits; LUSC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg22875332 chr1:76189707 ACADM 0.76 10.23 0.49 1.48e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3796619 0.503 rs1466216 chr4:1071907 C/T cg04106633 chr4:1044584 NA -0.33 -6.04 -0.31 4.04e-9 Recombination rate (males); LUSC cis rs34779708 0.966 rs12782948 chr10:35450607 G/A cg04310649 chr10:35416472 CREM -0.42 -6.62 -0.34 1.41e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12188164 0.580 rs2672755 chr5:457249 G/T cg16584290 chr5:462447 EXOC3 0.44 7.58 0.38 3.45e-13 Cystic fibrosis severity; LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg13395646 chr4:1353034 KIAA1530 -0.67 -11.29 -0.53 3.04e-25 Longevity; LUSC cis rs6733011 0.506 rs11123755 chr2:99507948 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.0 -0.31 5.24e-9 Bipolar disorder; LUSC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg09034736 chr1:150693464 HORMAD1 0.5 7.31 0.37 2.02e-12 Tonsillectomy; LUSC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.35 -0.37 1.5e-12 Aortic root size; LUSC cis rs6835098 0.962 rs10014010 chr4:174083230 C/T cg08422745 chr4:174089978 GALNT7 -0.84 -13.72 -0.6 2.8e-34 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.07 0.48 5.23e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg11812906 chr14:75593930 NEK9 0.67 11.72 0.54 8.64e-27 Height; LUSC cis rs7191700 0.511 rs8043625 chr16:11361895 C/G cg00044050 chr16:11439710 C16orf75 -0.7 -12.43 -0.56 2.04e-29 Multiple sclerosis; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg12419862 chr22:24373484 LOC391322 -0.87 -14.28 -0.62 1.84e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs5770917 1.000 rs1557503 chr22:51013072 G/A cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.66 -5.81 -0.3 1.46e-8 Narcolepsy; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg17372223 chr3:52568218 NT5DC2 0.39 6.14 0.32 2.3e-9 Electroencephalogram traits; LUSC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg13628971 chr7:2884303 GNA12 0.45 6.41 0.33 5e-10 Height; LUSC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg00012203 chr2:219082015 ARPC2 -0.7 -11.59 -0.54 2.53e-26 Colorectal cancer; LUSC cis rs7267979 0.744 rs6050464 chr20:25209299 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.69 13.23 0.59 2.06e-32 Liver enzyme levels (alkaline phosphatase); LUSC cis rs16854884 0.657 rs35796781 chr3:143731662 T/C cg06585982 chr3:143692056 C3orf58 0.46 7.18 0.37 4.44e-12 Economic and political preferences (feminism/equality); LUSC cis rs1595825 0.891 rs16825181 chr2:198740276 G/T cg00982548 chr2:198649783 BOLL -0.53 -6.32 -0.33 8.14e-10 Ulcerative colitis; LUSC cis rs5758511 0.680 rs5758699 chr22:42688034 C/G cg00645731 chr22:42541494 CYP2D7P1 0.59 10.12 0.48 3.57e-21 Birth weight; LUSC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg22467129 chr15:76604101 ETFA -0.44 -6.94 -0.36 2.02e-11 Blood metabolite levels; LUSC cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg04455712 chr21:45112962 RRP1B 0.47 8.86 0.44 4.7e-17 Mean corpuscular volume; LUSC cis rs6665290 0.901 rs61834004 chr1:227202782 G/A cg10327440 chr1:227177885 CDC42BPA -1.2 -35.46 -0.89 2.9e-115 Myeloid white cell count; LUSC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg06636001 chr8:8085503 FLJ10661 -0.56 -8.61 -0.43 2.94e-16 Neuroticism; LUSC cis rs7824557 0.767 rs28507159 chr8:11166076 C/T cg21775007 chr8:11205619 TDH 0.72 11.49 0.53 5.59e-26 Retinal vascular caliber; LUSC cis rs1358748 0.522 rs1321152 chr1:67583666 A/T cg02640540 chr1:67518911 SLC35D1 0.67 6.53 0.34 2.5e-10 Tuberculosis; LUSC cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg26373071 chr5:1325741 CLPTM1L -0.43 -8.17 -0.41 6.58e-15 Lung cancer; LUSC cis rs8017423 0.669 rs7153190 chr14:90703904 T/G cg14092571 chr14:90743983 NA -0.35 -5.67 -0.3 3.16e-8 Mortality in heart failure; LUSC cis rs1949733 1.000 rs6837429 chr4:8502374 A/G cg11789530 chr4:8429930 ACOX3 0.62 9.37 0.46 1.09e-18 Response to antineoplastic agents; LUSC cis rs9800506 0.584 rs9470056 chr6:35522145 A/G cg03566752 chr6:35512600 NA -0.35 -7.96 -0.4 2.73e-14 Neutrophil percentage of granulocytes; LUSC cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.98 16.67 0.67 7.84e-46 Cognitive ability; LUSC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg13390004 chr1:15929781 NA 0.4 6.65 0.34 1.19e-10 Systolic blood pressure; LUSC cis rs7020830 0.931 rs3802422 chr9:37097172 G/A cg14294708 chr9:37120828 ZCCHC7 1.1 25.67 0.81 5.28e-81 Schizophrenia; LUSC cis rs7927771 0.524 rs4539273 chr11:47694699 C/T cg20307385 chr11:47447363 PSMC3 -0.43 -6.38 -0.33 6e-10 Subjective well-being; LUSC trans rs12579753 1.000 rs10862371 chr12:82249298 C/T cg07923666 chr12:49932857 KCNH3 -0.51 -6.27 -0.32 1.15e-9 Resting heart rate; LUSC cis rs12908161 0.920 rs35738019 chr15:85280210 T/C cg17173187 chr15:85201210 NMB 0.5 9.31 0.45 1.77e-18 Schizophrenia; LUSC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg05585544 chr11:47624801 NA 0.41 7.25 0.37 2.92e-12 Subjective well-being; LUSC cis rs1559088 0.847 rs6510348 chr19:33601946 G/A cg03563238 chr19:33554763 RHPN2 -0.4 -6.43 -0.33 4.3e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs612683 0.690 rs11166440 chr1:100808363 C/T cg06223162 chr1:101003688 GPR88 -0.33 -5.83 -0.3 1.34e-8 Breast cancer; LUSC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg17971929 chr21:40555470 PSMG1 -0.47 -7.13 -0.36 6.12e-12 Menarche (age at onset); LUSC cis rs11608355 0.545 rs11609019 chr12:109895958 G/A cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC trans rs17685 0.753 rs2286830 chr7:75693963 C/T cg19862616 chr7:65841803 NCRNA00174 -1.13 -19.54 -0.73 3.21e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9837602 0.935 rs17392948 chr3:99754498 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.72 -0.3 2.35e-8 Breast cancer; LUSC cis rs10170846 0.861 rs7571732 chr2:223538316 A/C cg25565276 chr2:223520875 FARSB -0.62 -9.3 -0.45 1.93e-18 Schizophrenia (inflammation and infection response interaction); LUSC cis rs868036 0.681 rs4548812 chr15:68060552 G/A cg05925327 chr15:68127851 NA -0.4 -6.47 -0.33 3.41e-10 Restless legs syndrome; LUSC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg13647721 chr17:30228624 UTP6 0.64 6.9 0.35 2.68e-11 Hip circumference adjusted for BMI; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10192369 chr8:42195962 POLB -0.4 -5.95 -0.31 6.72e-9 Electrocardiographic conduction measures; LUSC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg06022373 chr22:39101656 GTPBP1 0.8 12.53 0.57 8.45e-30 Menopause (age at onset); LUSC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg16414030 chr3:133502952 NA -0.43 -6.59 -0.34 1.72e-10 Iron status biomarkers; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg12419862 chr22:24373484 LOC391322 0.86 14.15 0.61 6.16e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4242434 0.927 rs13264187 chr8:22506098 C/T cg03733263 chr8:22462867 KIAA1967 0.94 15.78 0.65 2.53e-42 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs7712401 0.601 rs246268 chr5:122256342 C/T cg19077854 chr5:122220652 SNX24 0.45 10.63 0.5 6.52e-23 Mean platelet volume; LUSC cis rs262150 0.522 rs2527182 chr7:158813812 A/G cg19418458 chr7:158789849 NA -0.63 -10.4 -0.49 4.1e-22 Facial morphology (factor 20); LUSC cis rs11166629 0.637 rs10283108 chr8:135575046 A/G cg27224718 chr8:135614730 ZFAT 0.52 7.56 0.38 4.01e-13 Smoking quantity; LUSC cis rs3925075 0.966 rs7195945 chr16:31344309 T/C cg02846316 chr16:31340340 ITGAM 0.35 6.53 0.34 2.48e-10 IgA nephropathy; LUSC cis rs2219968 0.638 rs10504672 chr8:78995199 G/C cg00738934 chr8:78996279 NA 0.41 7.3 0.37 2.16e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs240764 0.853 rs12206182 chr6:101033379 A/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.06 -0.31 3.78e-9 Neuroticism; LUSC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg19678392 chr7:94953810 PON1 -0.36 -5.92 -0.31 8.15e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg13319975 chr6:146136371 FBXO30 -0.47 -6.84 -0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6500395 0.775 rs7185541 chr16:48664681 A/G cg04672837 chr16:48644449 N4BP1 0.47 7.02 0.36 1.22e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7084921 0.578 rs11592631 chr10:101878219 G/A cg11888571 chr10:102027403 CWF19L1 -0.46 -6.15 -0.32 2.24e-9 Bone mineral density; LUSC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.5 -7.09 -0.36 8.01e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg17554472 chr22:41940697 POLR3H -0.47 -5.82 -0.3 1.4e-8 Vitiligo; LUSC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg06636001 chr8:8085503 FLJ10661 0.61 9.59 0.46 2.12e-19 Mood instability; LUSC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg27170947 chr2:26402098 FAM59B -0.63 -9.29 -0.45 1.97e-18 Gut microbiome composition (summer); LUSC cis rs11055008 0.620 rs12816452 chr12:12833006 A/T cg04607235 chr12:12878440 APOLD1 -0.48 -7.54 -0.38 4.42e-13 Pulse pressure; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg00166722 chr3:10149974 C3orf24 0.62 8.7 0.43 1.55e-16 Alzheimer's disease; LUSC trans rs4889911 1.000 rs4889910 chr17:77839795 C/T cg21635203 chr3:181429911 SOX2;SOX2OT -0.4 -6.01 -0.31 4.86e-9 Electroencephalogram traits; LUSC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06544989 chr22:39130855 UNC84B 0.33 5.67 0.3 3.08e-8 Menopause (age at onset); LUSC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg18876405 chr7:65276391 NA -0.57 -9.23 -0.45 3.24e-18 Aortic root size; LUSC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg07395648 chr5:131743802 NA 0.47 7.53 0.38 4.88e-13 Breast cancer;Mosquito bite size; LUSC cis rs12760731 0.720 rs71628282 chr1:178449993 C/G cg00404053 chr1:178313656 RASAL2 0.65 6.81 0.35 4.46e-11 Obesity-related traits; LUSC trans rs61931739 0.500 rs10844789 chr12:34202279 C/G cg26384229 chr12:38710491 ALG10B 0.74 12.08 0.55 4.07e-28 Morning vs. evening chronotype; LUSC cis rs727505 0.954 rs55768077 chr7:124663216 A/G cg23710748 chr7:124431027 NA -0.39 -6.87 -0.35 3.17e-11 Lewy body disease; LUSC cis rs11690935 0.885 rs6752812 chr2:172851502 C/A cg13550731 chr2:172543902 DYNC1I2 -0.8 -12.83 -0.57 6.6e-31 Schizophrenia; LUSC cis rs4356932 0.691 rs4859582 chr4:76907213 T/C cg00809888 chr4:76862425 NAAA 0.36 5.79 0.3 1.58e-8 Blood protein levels; LUSC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg24675658 chr1:53192096 ZYG11B -0.73 -12.0 -0.55 8.02e-28 Monocyte count; LUSC cis rs6681460 0.549 rs963140 chr1:67037576 T/G cg02459107 chr1:67143332 SGIP1 0.31 5.66 0.3 3.3e-8 Presence of antiphospholipid antibodies; LUSC cis rs793571 0.669 rs28864995 chr15:58945671 T/G cg05156742 chr15:59063176 FAM63B 0.59 8.44 0.42 9.75e-16 Schizophrenia; LUSC cis rs17540621 1.000 rs78201922 chr2:47246771 A/G cg23978866 chr2:47230407 TTC7A -0.89 -6.27 -0.32 1.13e-9 Response to statin therapy; LUSC cis rs9894429 0.608 rs8477 chr17:79618059 C/T cg09655341 chr17:79618100 PDE6G -0.27 -6.12 -0.32 2.68e-9 Eye color traits; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg22963979 chr7:1858916 MAD1L1 -0.59 -8.97 -0.44 2.22e-17 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg03579872 chr1:53393473 SCP2 -0.39 -5.66 -0.3 3.27e-8 Monocyte count; LUSC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg12863693 chr15:85201151 NMB 0.33 6.62 0.34 1.43e-10 Schizophrenia; LUSC cis rs9815354 1.000 rs9855965 chr3:41860508 C/T cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.55e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg11266682 chr4:10021025 SLC2A9 0.53 9.93 0.48 1.52e-20 Bone mineral density; LUSC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg12311346 chr5:56204834 C5orf35 -0.58 -9.06 -0.44 1.16e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs7914558 0.646 rs10883799 chr10:104663310 G/A cg05855489 chr10:104503620 C10orf26 0.42 5.76 0.3 1.92e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg24846343 chr22:24311635 DDTL 0.7 13.81 0.6 1.25e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7916697 0.947 rs1900004 chr10:70000881 C/T cg06988349 chr10:69991859 ATOH7 0.37 6.6 0.34 1.58e-10 Optic disc area; LUSC cis rs7075426 0.669 rs10887607 chr10:88190354 A/G cg07322936 chr10:88137208 NA 0.44 6.34 0.33 7.27e-10 Migraine without aura; LUSC cis rs7582720 1.000 rs72934729 chr2:203737770 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg21770322 chr7:97807741 LMTK2 0.41 7.01 0.36 1.32e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.9 -0.58 3.72e-31 Alzheimer's disease; LUSC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg09455208 chr3:40491958 NA 0.52 8.95 0.44 2.6e-17 Renal cell carcinoma; LUSC cis rs765787 0.530 rs7167731 chr15:45510900 T/C cg25801113 chr15:45476975 SHF -0.34 -6.7 -0.34 8.69e-11 Uric acid levels; LUSC cis rs9300255 0.639 rs1716171 chr12:123716376 C/T cg05973401 chr12:123451056 ABCB9 0.53 6.59 0.34 1.73e-10 Neutrophil percentage of white cells; LUSC cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg13010199 chr12:38710504 ALG10B 0.7 11.61 0.54 2.02e-26 Heart rate; LUSC cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg24596788 chr1:163392923 NA -0.45 -7.62 -0.38 2.6e-13 Motion sickness; LUSC cis rs59724122 0.542 rs28633173 chr8:27446980 A/G cg19442470 chr8:27470225 CLU 0.33 5.74 0.3 2.16e-8 Bipolar disorder lithium response (categorical) or schizophrenia; LUSC cis rs9314323 0.767 rs6557915 chr8:26209062 C/A cg11498726 chr8:26250323 BNIP3L -0.43 -6.1 -0.32 2.96e-9 Red cell distribution width; LUSC cis rs4363385 0.669 rs2937264 chr1:153011026 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs8141529 0.732 rs6005881 chr22:29183133 A/G cg02153584 chr22:29168773 CCDC117 0.65 10.24 0.49 1.39e-21 Lymphocyte counts; LUSC cis rs10754283 0.967 rs7528433 chr1:90114071 T/C cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7917772 0.539 rs12572775 chr10:104285594 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -10.23 -0.49 1.47e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg08219700 chr8:58056026 NA 0.69 8.07 0.4 1.27e-14 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg05347473 chr6:146136440 FBXO30 0.42 7.25 0.37 3.01e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs56404399 chr12:34543101 A/G cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC trans rs61931739 0.534 rs28548399 chr12:34188151 G/A cg26384229 chr12:38710491 ALG10B 0.74 11.9 0.55 1.78e-27 Morning vs. evening chronotype; LUSC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg26061582 chr7:22766209 IL6 0.49 7.02 0.36 1.25e-11 Lung cancer; LUSC trans rs8002861 0.967 rs7994883 chr13:44478805 A/G cg17145862 chr1:211918768 LPGAT1 -0.23 -6.26 -0.32 1.16e-9 Leprosy; LUSC cis rs9905704 0.836 rs302875 chr17:56767874 A/G cg12560992 chr17:57184187 TRIM37 -0.52 -7.22 -0.37 3.62e-12 Testicular germ cell tumor; LUSC cis rs11229555 1.000 rs1938598 chr11:58413910 T/C cg15696309 chr11:58395628 NA -0.67 -8.87 -0.44 4.44e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg11645453 chr3:52864694 ITIH4 0.35 8.09 0.4 1.09e-14 Bipolar disorder; LUSC cis rs738322 0.870 rs5750558 chr22:38582497 G/A cg17652424 chr22:38574118 PLA2G6 0.27 5.77 0.3 1.82e-8 Cutaneous nevi; LUSC cis rs4443100 0.837 rs6003490 chr22:23388447 G/A cg14186256 chr22:23484241 RTDR1 0.5 6.15 0.32 2.16e-9 Serum parathyroid hormone levels; LUSC cis rs3741151 0.686 rs7927344 chr11:73207517 T/C cg17517138 chr11:73019481 ARHGEF17 0.83 7.71 0.39 1.48e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs36051895 0.623 rs1555476 chr9:5233054 T/C cg02405213 chr9:5042618 JAK2 -0.58 -8.0 -0.4 2.07e-14 Pediatric autoimmune diseases; LUSC trans rs7094131 0.542 rs7071306 chr10:22867339 A/G cg05996795 chr6:134159303 MGC34034 0.42 6.39 0.33 5.63e-10 Obesity-related traits; LUSC cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg04455712 chr21:45112962 RRP1B -0.44 -8.38 -0.42 1.49e-15 Mean corpuscular volume; LUSC cis rs7809950 1.000 rs2237673 chr7:107131580 T/C cg23024343 chr7:107201750 COG5 -0.55 -8.91 -0.44 3.39e-17 Coronary artery disease; LUSC cis rs6547741 1.000 rs6547740 chr2:27854369 C/T cg12559939 chr2:27858050 GPN1 0.41 6.24 0.32 1.32e-9 Oral cavity cancer; LUSC cis rs66887589 1.000 rs66887589 chr4:120509279 T/C cg24375607 chr4:120327624 NA -0.49 -7.51 -0.38 5.59e-13 Diastolic blood pressure; LUSC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18404041 chr3:52824283 ITIH1 -0.54 -10.39 -0.49 4.23e-22 Electroencephalogram traits; LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.89 -12.69 -0.57 2.2e-30 Platelet count; LUSC cis rs7106204 0.534 rs7928616 chr11:24296060 T/C ch.11.24196551F chr11:24239977 NA 0.87 9.27 0.45 2.38e-18 Response to Homoharringtonine (cytotoxicity); LUSC trans rs11098499 1.000 rs11098500 chr4:120219239 T/A cg25214090 chr10:38739885 LOC399744 0.49 7.14 0.36 5.83e-12 Corneal astigmatism; LUSC cis rs7072216 0.763 rs10883091 chr10:100167239 C/T cg26618903 chr10:100175079 PYROXD2 -0.46 -8.71 -0.43 1.39e-16 Metabolite levels; LUSC cis rs4851254 0.618 rs35730185 chr2:100648085 G/A cg07810366 chr2:100720526 AFF3 -0.46 -5.95 -0.31 6.76e-9 Intelligence (multi-trait analysis); LUSC cis rs12681287 0.640 rs10098356 chr8:87442667 A/G cg27223183 chr8:87520930 FAM82B 0.54 7.47 0.38 6.96e-13 Caudate activity during reward; LUSC cis rs11190604 1.000 rs76683169 chr10:102358397 A/T cg16342193 chr10:102329863 NA -0.37 -6.26 -0.32 1.21e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7582180 0.638 rs6734316 chr2:100976210 A/G cg08017756 chr2:100939284 LONRF2 -0.44 -8.23 -0.41 4.12e-15 Intelligence (multi-trait analysis); LUSC cis rs4295623 0.507 rs2256241 chr8:11494657 C/T cg00262122 chr8:11665843 FDFT1 -0.38 -5.87 -0.31 1.04e-8 Morning vs. evening chronotype; LUSC cis rs41271473 1.000 rs4993975 chr1:228878669 A/C cg10167378 chr1:228756711 NA 0.54 6.59 0.34 1.72e-10 Chronic lymphocytic leukemia; LUSC cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg25251562 chr2:3704773 ALLC -0.75 -12.42 -0.56 2.26e-29 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs6430585 0.528 rs309166 chr2:136667487 C/T cg07169764 chr2:136633963 MCM6 1.03 15.71 0.65 4.82e-42 Corneal structure; LUSC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg03806693 chr22:41940476 POLR3H 0.99 14.14 0.61 6.88e-36 Vitiligo; LUSC cis rs8077889 1.000 rs2066725 chr17:41891473 A/G cg26893861 chr17:41843967 DUSP3 0.87 13.1 0.58 6.35e-32 Triglycerides; LUSC trans rs61931739 0.500 rs7965679 chr12:34542494 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs1559088 0.901 rs7249983 chr19:33598851 C/A cg27124370 chr19:33622961 WDR88 0.56 7.34 0.37 1.67e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs3857536 0.813 rs9354404 chr6:66948408 C/T cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs17401966 1.000 rs12132635 chr1:10430479 G/A cg19773385 chr1:10388646 KIF1B -0.53 -8.23 -0.41 4.24e-15 Hepatocellular carcinoma; LUSC cis rs72781680 0.660 rs72780104 chr2:23983715 A/G cg08917208 chr2:24149416 ATAD2B 0.87 9.72 0.47 8.05e-20 Lymphocyte counts; LUSC cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg26597838 chr10:835615 NA 0.79 9.6 0.47 1.9e-19 Eosinophil percentage of granulocytes; LUSC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg06618935 chr21:46677482 NA 0.37 7.45 0.38 8.21e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg10792982 chr14:105748885 BRF1 0.49 8.88 0.44 4.19e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs2797160 0.967 rs1739368 chr6:126011079 C/T cg05901451 chr6:126070800 HEY2 0.57 8.52 0.42 5.4e-16 Endometrial cancer; LUSC cis rs1160297 0.609 rs12713231 chr2:53105695 C/G cg07782112 chr2:53107842 NA 0.38 6.47 0.33 3.59e-10 Hemostatic factors and hematological phenotypes; LUSC trans rs853679 0.607 rs13197574 chr6:28060239 T/C cg01620082 chr3:125678407 NA -0.87 -7.55 -0.38 4.28e-13 Depression; LUSC cis rs965469 1.000 rs6051712 chr20:3265029 T/A cg25506879 chr20:3388711 C20orf194 -0.52 -5.84 -0.3 1.27e-8 IFN-related cytopenia; LUSC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg07343612 chr16:622815 PIGQ -0.74 -12.65 -0.57 2.98e-30 Height; LUSC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg25019033 chr10:957182 NA -0.53 -6.64 -0.34 1.24e-10 Eosinophil percentage of granulocytes; LUSC cis rs7712401 0.601 rs436546 chr5:122322790 G/A cg19077854 chr5:122220652 SNX24 -0.43 -9.54 -0.46 3.21e-19 Mean platelet volume; LUSC cis rs72781680 0.799 rs2551332 chr2:23988950 T/C cg08917208 chr2:24149416 ATAD2B 0.6 6.86 0.35 3.27e-11 Lymphocyte counts; LUSC cis rs6087990 0.765 rs6058900 chr20:31400673 T/C cg13636640 chr20:31349939 DNMT3B 0.96 19.82 0.74 2.37e-58 Ulcerative colitis; LUSC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg13319975 chr6:146136371 FBXO30 0.71 11.11 0.52 1.24e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 0.898 rs56413706 chr2:24086961 G/A cg08917208 chr2:24149416 ATAD2B 0.98 10.26 0.49 1.15e-21 Lymphocyte counts; LUSC cis rs2076222 1.000 rs2076350 chr1:209800341 C/T cg00257659 chr1:209800214 LAMB3 -1.06 -8.58 -0.42 3.73e-16 Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03578331 chr2:161350329 RBMS1 -0.41 -6.54 -0.34 2.29e-10 Electrocardiographic conduction measures; LUSC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.98 0.4 2.31e-14 Hemoglobin concentration; LUSC cis rs3812762 0.868 rs7952335 chr11:8754031 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.37 6.49 0.33 3.17e-10 Hypospadias; LUSC cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.27 0.45 2.34e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg21573476 chr21:45109991 RRP1B -0.41 -6.83 -0.35 4.1e-11 Mean corpuscular volume; LUSC cis rs11785400 0.793 rs7459963 chr8:143737129 C/T cg24634471 chr8:143751801 JRK 0.5 7.18 0.37 4.56e-12 Schizophrenia; LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.87 11.46 0.53 7.29e-26 Alzheimer's disease; LUSC trans rs7615952 0.546 rs111812401 chr3:125361495 G/A cg07211511 chr3:129823064 LOC729375 -0.53 -6.1 -0.32 2.86e-9 Blood pressure (smoking interaction); LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg08888203 chr3:10149979 C3orf24 0.61 8.44 0.42 9.76e-16 Alzheimer's disease; LUSC cis rs1997103 1.000 rs4947503 chr7:55409427 G/T cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg02428538 chr16:24856791 SLC5A11 -0.51 -5.87 -0.31 1.05e-8 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs11122279 chr1:231519804 A/G cg06096015 chr1:231504339 EGLN1 0.57 9.97 0.48 1.16e-20 Hemoglobin concentration; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.71 10.94 0.51 5.17e-24 Lymphocyte counts; LUSC cis rs2290159 0.752 rs73130368 chr3:12667374 C/T cg23032965 chr3:12705835 RAF1 0.74 9.09 0.45 8.97e-18 Cholesterol, total; LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg18404041 chr3:52824283 ITIH1 -0.56 -10.63 -0.5 6.41e-23 Bipolar disorder; LUSC cis rs11190604 1.000 rs11190596 chr10:102293238 C/G cg07080220 chr10:102295463 HIF1AN 0.69 8.93 0.44 2.8e-17 Palmitoleic acid (16:1n-7) levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00235645 chr15:40886408 CASC5 -0.46 -6.84 -0.35 3.82e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg06873352 chr17:61820015 STRADA 0.72 12.98 0.58 1.83e-31 Prudent dietary pattern; LUSC cis rs11098499 0.743 rs11098501 chr4:120252017 T/G cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs11711311 1.000 rs16861312 chr3:113492402 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.99 0.36 1.47e-11 IgG glycosylation; LUSC cis rs10883723 0.810 rs12162 chr10:104240498 A/G cg05855489 chr10:104503620 C10orf26 -0.71 -8.54 -0.42 4.85e-16 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1045714 0.836 rs56246161 chr7:2644679 G/A cg24848437 chr7:2645542 IQCE 0.59 6.58 0.34 1.84e-10 Urate levels in lean individuals; LUSC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.45 -8.2 -0.41 5.2e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7089973 0.604 rs7915943 chr10:116618077 G/A cg03647239 chr10:116582469 FAM160B1 0.43 6.92 0.35 2.3e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1335645 0.570 rs7514887 chr1:111667158 T/C cg00321911 chr1:111669324 DRAM2 -0.63 -6.49 -0.33 3.19e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg02782426 chr3:40428986 ENTPD3 0.34 6.39 0.33 5.46e-10 Renal cell carcinoma; LUSC cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg26384229 chr12:38710491 ALG10B 0.88 14.33 0.62 1.26e-36 Bladder cancer; LUSC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg03676636 chr4:99064102 C4orf37 -0.34 -7.53 -0.38 4.89e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg15839431 chr19:19639596 YJEFN3 0.61 6.6 0.34 1.63e-10 Bipolar disorder; LUSC cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg25173405 chr17:45401733 C17orf57 0.36 5.72 0.3 2.36e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.1 -0.58 6.15e-32 Platelet count; LUSC cis rs2625529 0.824 rs4776586 chr15:72430503 C/A cg16672083 chr15:72433130 SENP8 -0.52 -7.57 -0.38 3.79e-13 Red blood cell count; LUSC trans rs2898290 0.622 rs978803 chr8:11343475 C/T cg06636001 chr8:8085503 FLJ10661 0.54 8.76 0.43 9.63e-17 Systolic blood pressure; LUSC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg06636001 chr8:8085503 FLJ10661 -0.68 -11.43 -0.53 9.22e-26 Mood instability; LUSC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg21361702 chr7:150065534 REPIN1 0.46 6.31 0.33 8.81e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs11190604 1.000 rs1800662 chr10:102289078 C/A cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.26e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs13217239 0.608 rs6930508 chr6:27053142 T/C cg05738196 chr6:26577821 NA -0.54 -8.48 -0.42 7.42e-16 Schizophrenia; LUSC cis rs9868809 0.505 rs11708786 chr3:48752654 C/T cg00383909 chr3:49044727 WDR6 0.96 10.08 0.48 5.04e-21 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2204008 0.777 rs8189597 chr12:38307739 G/C cg26384229 chr12:38710491 ALG10B -0.92 -15.64 -0.65 9.34e-42 Bladder cancer; LUSC trans rs941408 0.515 rs7253128 chr19:2776982 C/T cg19676328 chr12:49525230 TUBA1B -0.51 -7.37 -0.37 1.35e-12 Total cholesterol levels; LUSC cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg20503657 chr10:835505 NA -0.52 -7.14 -0.36 6.05e-12 Response to angiotensin II receptor blocker therapy; LUSC trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg15704280 chr7:45808275 SEPT13 -0.84 -11.72 -0.54 8.17e-27 Coronary artery disease; LUSC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.5 -6.91 -0.35 2.52e-11 Multiple sclerosis; LUSC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg14583973 chr4:3374767 RGS12 0.26 5.81 0.3 1.46e-8 Parental longevity (mother's age at death); LUSC cis rs9976767 0.637 rs2156309 chr21:43824529 G/A cg23042151 chr21:43824109 UBASH3A -0.35 -6.73 -0.35 7.21e-11 Type 1 diabetes; LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg08027265 chr7:2291960 NA -0.39 -6.27 -0.32 1.14e-9 Bipolar disorder and schizophrenia; LUSC cis rs7267979 1.000 rs4813562 chr20:25352588 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.43 -0.33 4.39e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12579753 0.917 rs7138533 chr12:82187885 C/G cg21231944 chr12:82153410 PPFIA2 -0.37 -5.68 -0.3 3.01e-8 Resting heart rate; LUSC cis rs11098499 0.645 rs72676059 chr4:120290828 C/G cg24375607 chr4:120327624 NA 0.69 10.58 0.5 9.19e-23 Corneal astigmatism; LUSC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg14298792 chr15:30685198 CHRFAM7A -0.49 -5.93 -0.31 7.45e-9 Huntington's disease progression; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01045986 chr18:29671767 RNF138 0.43 6.23 0.32 1.42e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs57221529 0.766 rs72703026 chr5:572383 G/A cg11887960 chr12:57824829 NA 0.56 6.73 0.35 7.6e-11 Lung disease severity in cystic fibrosis; LUSC cis rs7267979 0.903 rs6107015 chr20:25216764 G/A cg08601574 chr20:25228251 PYGB 0.48 7.41 0.38 1.03e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10465746 0.967 rs4907191 chr1:84444165 A/G cg10977910 chr1:84465055 TTLL7 -0.41 -6.05 -0.31 3.92e-9 Obesity-related traits; LUSC cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg13010199 chr12:38710504 ALG10B 0.66 11.52 0.53 4.55e-26 Heart rate; LUSC cis rs12950390 0.814 rs4794099 chr17:45838358 T/C cg06532163 chr17:45867833 NA 0.34 6.22 0.32 1.52e-9 IgG glycosylation; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg10361922 chr17:40925790 VPS25 0.36 5.95 0.31 6.65e-9 Mosquito bite size; LUSC cis rs7202877 0.706 rs8054586 chr16:75410705 G/C cg04384234 chr16:75411784 CFDP1 -0.65 -9.27 -0.45 2.43e-18 Type 2 diabetes;Type 1 diabetes; LUSC cis rs12986413 0.934 rs6510645 chr19:2158398 T/C cg09261902 chr19:2140048 AP3D1 0.33 6.15 0.32 2.25e-9 Height; LUSC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.7 0.34 9.06e-11 Intelligence (multi-trait analysis); LUSC cis rs57590327 0.503 rs2372906 chr3:81504673 G/A cg07356753 chr3:81810745 GBE1 0.46 6.07 0.32 3.38e-9 Extraversion; LUSC cis rs16854884 0.586 rs4527375 chr3:143735515 A/T cg06585982 chr3:143692056 C3orf58 -0.52 -8.57 -0.42 3.85e-16 Economic and political preferences (feminism/equality); LUSC trans rs57221529 0.713 rs72703072 chr5:590626 A/G cg11887960 chr12:57824829 NA 0.55 6.69 0.34 9.64e-11 Lung disease severity in cystic fibrosis; LUSC cis rs4073582 0.595 rs708471 chr11:65931008 A/G cg16950941 chr11:66035639 RAB1B 0.49 7.13 0.36 6.41e-12 Gout; LUSC cis rs7527798 0.592 rs11118360 chr1:207858586 G/A cg09232269 chr1:207846808 CR1L -0.3 -6.34 -0.33 7.3e-10 Erythrocyte sedimentation rate; LUSC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.62 -0.6 6.89e-34 Intelligence (multi-trait analysis); LUSC cis rs9303280 0.806 rs10445308 chr17:37938047 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.69 0.3 2.81e-8 Self-reported allergy; LUSC cis rs6424115 0.737 rs10917430 chr1:24170458 C/T cg15997130 chr1:24165203 NA -0.48 -7.22 -0.37 3.44e-12 Immature fraction of reticulocytes; LUSC cis rs2580764 0.565 rs35631428 chr2:55244438 G/A cg09592903 chr2:55203963 RTN4 -0.47 -9.5 -0.46 4.28e-19 Mean platelet volume; LUSC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg26597838 chr10:835615 NA 0.97 13.28 0.59 1.29e-32 Eosinophil percentage of granulocytes; LUSC cis rs2404602 0.669 rs12438540 chr15:76943213 C/G cg22467129 chr15:76604101 ETFA -0.42 -6.69 -0.34 9.56e-11 Blood metabolite levels; LUSC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg19257562 chr1:2043853 PRKCZ 0.32 6.4 0.33 5.18e-10 Height; LUSC trans rs9291683 0.530 rs10939620 chr4:9946132 C/T cg26043149 chr18:55253948 FECH -0.45 -6.77 -0.35 5.85e-11 Bone mineral density; LUSC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg23262073 chr20:60523788 NA -0.39 -5.69 -0.3 2.81e-8 Body mass index; LUSC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg10883421 chr6:151773342 RMND1;C6orf211 0.69 11.73 0.54 7.92e-27 Menarche (age at onset); LUSC cis rs12599106 0.629 rs1391904 chr16:34548934 C/T cg01585723 chr16:33734837 NA 0.35 5.7 0.3 2.66e-8 Menopause (age at onset); LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg07507251 chr3:52567010 NT5DC2 0.34 6.48 0.33 3.32e-10 Bipolar disorder; LUSC cis rs12478296 0.591 rs6746311 chr2:243001279 A/G cg06360820 chr2:242988706 NA -0.64 -8.32 -0.41 2.32e-15 Obesity-related traits; LUSC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg09323728 chr8:95962352 TP53INP1 -0.37 -7.62 -0.38 2.62e-13 Type 2 diabetes; LUSC cis rs7215564 0.818 rs34756632 chr17:78618859 C/T cg09596252 chr17:78655493 RPTOR 0.55 5.89 0.31 9.17e-9 Myopia (pathological); LUSC cis rs6009527 1.000 rs6009188 chr22:49572751 G/A cg12746016 chr22:49560550 NA 0.37 6.22 0.32 1.51e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs1949733 0.543 rs62287446 chr4:8535988 G/A cg11789530 chr4:8429930 ACOX3 -0.4 -5.98 -0.31 5.59e-9 Response to antineoplastic agents; LUSC cis rs55665837 1.000 rs12295723 chr11:14450201 T/C cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs72781680 1.000 rs56339200 chr2:24188194 C/A cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs7799006 0.782 rs2159044 chr7:2262941 C/A cg08027265 chr7:2291960 NA -0.36 -6.02 -0.31 4.65e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9341808 0.718 rs7740627 chr6:80916347 A/G cg08355045 chr6:80787529 NA 0.58 10.18 0.49 2.23e-21 Sitting height ratio; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg27535305 chr1:53392650 SCP2 -0.47 -9.1 -0.45 8.12e-18 Monocyte count; LUSC cis rs250677 0.916 rs17109279 chr5:148416581 A/G cg12140854 chr5:148520817 ABLIM3 -0.35 -5.79 -0.3 1.66e-8 Breast cancer; LUSC cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.29 0.37 2.21e-12 Motion sickness; LUSC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.55 -0.34 2.11e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs13089785 1.000 rs2332682 chr3:123654633 C/T cg19611163 chr3:123411211 MYLK 0.35 6.08 0.32 3.2e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs10744422 0.800 rs1696320 chr12:123269814 A/G cg25930673 chr12:123319894 HIP1R -0.58 -5.98 -0.31 5.68e-9 Schizophrenia; LUSC cis rs7954584 0.567 rs11612028 chr12:122387872 C/G cg13699009 chr12:122356056 WDR66 0.5 7.86 0.4 5.39e-14 Mean corpuscular volume; LUSC cis rs7084921 0.608 rs11596883 chr10:101861622 T/C cg11888571 chr10:102027403 CWF19L1 -0.42 -5.71 -0.3 2.47e-8 Bone mineral density; LUSC cis rs155346 1.000 rs155345 chr5:139397250 C/T cg01090482 chr5:139365336 NRG2 -0.38 -6.18 -0.32 1.88e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg11062466 chr8:58055876 NA 0.7 9.34 0.46 1.41e-18 Developmental language disorder (linguistic errors); LUSC trans rs7613875 0.578 rs2526749 chr3:50076734 A/G cg21659725 chr3:3221576 CRBN -0.52 -8.37 -0.42 1.61e-15 Body mass index; LUSC cis rs7011049 1.000 rs11995106 chr8:53834768 C/T cg26025543 chr8:53854495 NA 0.51 6.3 0.33 9.53e-10 Systolic blood pressure; LUSC trans rs1493916 0.721 rs4799723 chr18:31367050 T/G cg13755796 chr4:20253514 NA -0.42 -6.61 -0.34 1.49e-10 Life satisfaction; LUSC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1023500 0.596 rs133352 chr22:42434022 C/A cg15557168 chr22:42548783 NA -0.43 -6.49 -0.33 3.09e-10 Schizophrenia; LUSC cis rs11214589 0.875 rs10891540 chr11:113239082 A/G cg14159747 chr11:113255604 NA -0.27 -7.08 -0.36 8.78e-12 Neuroticism; LUSC cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg03676636 chr4:99064102 C4orf37 0.34 6.21 0.32 1.58e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg06108461 chr20:60628389 TAF4 -0.75 -12.24 -0.56 1.01e-28 Body mass index; LUSC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs4729127 1.000 rs4729118 chr7:93982877 T/C cg20086523 chr13:52378287 DHRS12 0.57 6.12 0.32 2.61e-9 Intelligence; LUSC cis rs2262909 0.962 rs1526884 chr19:22303651 A/G cg11619707 chr19:22235551 ZNF257 0.39 5.89 0.31 9.62e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs500891 0.533 rs945238 chr6:84165856 C/T cg08257003 chr6:84140564 ME1 0.39 9.78 0.47 5.12e-20 Platelet-derived growth factor BB levels; LUSC cis rs1506636 0.511 rs62484466 chr7:123174880 T/A cg03229431 chr7:123269106 ASB15 0.47 6.9 0.35 2.68e-11 Plateletcrit;Platelet count; LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg04267008 chr7:1944627 MAD1L1 -0.57 -8.51 -0.42 5.89e-16 Bipolar disorder and schizophrenia; LUSC cis rs1358748 0.573 rs7529446 chr1:67581576 A/C cg02640540 chr1:67518911 SLC35D1 0.67 6.53 0.34 2.5e-10 Tuberculosis; LUSC cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs757081 0.667 rs1987694 chr11:17107648 G/C cg15432903 chr11:17409602 KCNJ11 -0.39 -6.04 -0.31 4e-9 Systolic blood pressure; LUSC cis rs1801251 1.000 rs6738386 chr2:233602028 T/C cg25237894 chr2:233734115 C2orf82 0.34 6.21 0.32 1.59e-9 Coronary artery disease; LUSC cis rs7267979 0.565 rs4815432 chr20:25556403 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -12.67 -0.57 2.7e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs887829 0.570 rs7608175 chr2:234599089 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.4 6.54 0.34 2.35e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs72674100 0.867 rs3974980 chr4:97963716 T/C cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg27121462 chr16:89883253 FANCA 0.43 6.64 0.34 1.25e-10 Vitiligo; LUSC cis rs7481584 0.624 rs377765 chr11:3046298 C/T cg25174290 chr11:3078921 CARS -0.42 -6.27 -0.32 1.11e-9 Calcium levels; LUSC trans rs911555 0.692 rs60235428 chr14:103904350 T/C cg17675199 chr6:35436792 RPL10A -0.41 -6.11 -0.32 2.73e-9 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg13319975 chr6:146136371 FBXO30 0.45 6.78 0.35 5.49e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.72 0.43 1.34e-16 Prudent dietary pattern; LUSC trans rs35110281 0.774 rs2838321 chr21:44995488 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.56 9.23 0.45 3.1e-18 Mean corpuscular volume; LUSC cis rs2273669 0.667 rs76367548 chr6:109356589 C/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg00684032 chr4:1343700 KIAA1530 0.33 5.84 0.3 1.25e-8 Obesity-related traits; LUSC cis rs354225 0.584 rs11898032 chr2:54821515 G/A cg01766943 chr2:54829624 SPTBN1 0.49 8.01 0.4 1.91e-14 Schizophrenia; LUSC trans rs4729127 1.000 rs4727297 chr7:93984947 C/T cg20086523 chr13:52378287 DHRS12 0.57 6.12 0.32 2.64e-9 Intelligence; LUSC cis rs2070488 0.804 rs13085153 chr3:38461279 A/G cg24069376 chr3:38537580 EXOG 0.37 7.33 0.37 1.72e-12 Electrocardiographic conduction measures; LUSC trans rs853679 0.517 rs9295759 chr6:28124469 C/T cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.19e-9 Depression; LUSC cis rs548181 0.736 rs540436 chr11:125512619 A/G cg03464685 chr11:125439445 EI24 1.04 12.18 0.55 1.78e-28 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6750795 0.569 rs1667308 chr2:232406344 T/C cg19187155 chr2:232395269 NMUR1 0.8 13.92 0.61 4.61e-35 Height; LUSC cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.38 0.33 6.05e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg08355456 chr11:67383691 NA -0.37 -6.46 -0.33 3.62e-10 Mean corpuscular volume; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02010894 chr19:16653629 CHERP 0.77 6.08 0.32 3.33e-9 Cognitive performance; LUSC cis rs6736093 0.966 rs11692445 chr2:112704033 T/G cg12686935 chr2:112915763 FBLN7 -0.37 -5.87 -0.31 1.02e-8 Coronary artery disease; LUSC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg22875332 chr1:76189707 ACADM 0.85 15.67 0.65 6.91e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6456156 0.565 rs7750209 chr6:167482895 T/G cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs8135665 0.600 rs8139025 chr22:38450881 G/C cg13116946 chr22:38479732 SLC16A8 0.42 6.22 0.32 1.52e-9 Advanced age-related macular degeneration;Age-related macular degeneration; LUSC cis rs9303401 0.659 rs17222691 chr17:56771096 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.0 0.58 1.45e-31 Cognitive test performance; LUSC cis rs9928842 0.823 rs2870472 chr16:75278841 C/G cg09066997 chr16:75300724 BCAR1 0.5 6.51 0.34 2.71e-10 Alcoholic chronic pancreatitis; LUSC cis rs4237845 0.537 rs59401446 chr12:58259564 G/A cg02175503 chr12:58329896 NA 0.49 7.16 0.36 5.03e-12 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg09365446 chr1:150670422 GOLPH3L 0.46 6.74 0.35 7.09e-11 Melanoma; LUSC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg20503657 chr10:835505 NA 1.22 16.05 0.66 2.2e-43 Eosinophil percentage of granulocytes; LUSC trans rs970548 0.738 rs61854124 chr10:46077158 T/C cg14222797 chr10:16859974 RSU1 -0.57 -6.04 -0.31 4.07e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs12900413 0.802 rs11634377 chr15:90295583 C/T cg24249390 chr15:90295951 MESP1 -0.48 -7.25 -0.37 2.83e-12 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs10435719 0.899 rs11250177 chr8:11799099 G/A cg06636001 chr8:8085503 FLJ10661 0.54 8.01 0.4 1.95e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg01689657 chr7:91764605 CYP51A1 0.33 6.0 0.31 5.03e-9 Breast cancer; LUSC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9303401 0.659 rs36093395 chr17:56957357 C/T cg25039879 chr17:56429692 SUPT4H1 0.68 9.11 0.45 7.7e-18 Cognitive test performance; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg08736216 chr1:53307985 ZYG11A -0.29 -6.04 -0.31 4.11e-9 Monocyte count; LUSC cis rs11585357 0.895 rs112208664 chr1:17632010 G/A cg08277548 chr1:17600880 PADI3 -0.59 -6.21 -0.32 1.56e-9 Hair shape; LUSC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg14456004 chr13:21872349 NA 1.26 19.3 0.73 2.74e-56 White matter hyperintensity burden; LUSC trans rs6502050 0.835 rs7502548 chr17:80087569 T/C cg07393940 chr7:158741817 NA -0.37 -6.68 -0.34 1.02e-10 Life satisfaction; LUSC cis rs2658782 0.789 rs2658775 chr11:93126799 C/T cg15737290 chr11:93063684 CCDC67 0.64 7.92 0.4 3.59e-14 Pulmonary function decline; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17465063 chr10:111985564 MXI1 -0.42 -6.27 -0.32 1.08e-9 Electrocardiographic conduction measures; LUSC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg12560992 chr17:57184187 TRIM37 0.83 15.22 0.64 4.28e-40 Intelligence (multi-trait analysis); LUSC cis rs9400467 0.528 rs455335 chr6:111675516 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs1020064 0.609 rs2576748 chr2:105911258 A/C cg02079111 chr2:105885981 TGFBRAP1 -0.44 -6.24 -0.32 1.3e-9 AIDS; LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.2 0.37 4.08e-12 Gut microbiome composition (summer); LUSC cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg13256891 chr4:100009986 ADH5 0.46 6.32 0.33 8.54e-10 Alcohol dependence; LUSC cis rs1014246 0.848 rs758362 chr10:118457905 G/A cg14919929 chr10:118506882 NA 0.45 7.19 0.37 4.15e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7189233 0.955 rs8044205 chr16:53515093 T/C cg04059762 chr16:53544020 NA -0.32 -5.79 -0.3 1.67e-8 Intelligence (multi-trait analysis); LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg16325326 chr1:53192061 ZYG11B -0.92 -17.21 -0.69 5.71e-48 Monocyte count; LUSC cis rs7512552 0.803 rs13294 chr1:150484987 G/A cg15654264 chr1:150340011 RPRD2 0.57 9.15 0.45 5.83e-18 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs4654899 0.802 rs12123910 chr1:21233316 C/T cg02927042 chr1:21476669 EIF4G3 -0.38 -5.96 -0.31 6.51e-9 Superior frontal gyrus grey matter volume; LUSC cis rs9300255 0.679 rs12829456 chr12:123725395 C/T cg13010344 chr12:123464640 ARL6IP4 0.48 5.84 0.3 1.25e-8 Neutrophil percentage of white cells; LUSC cis rs1113500 0.933 rs11185259 chr1:108635062 A/G cg06207961 chr1:108661230 NA -0.41 -7.38 -0.37 1.24e-12 Growth-regulated protein alpha levels; LUSC cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg00484396 chr16:3507460 NAT15 -0.47 -7.01 -0.36 1.29e-11 Body mass index (adult); LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg25894440 chr7:65020034 NA 0.39 6.14 0.32 2.33e-9 Calcium levels; LUSC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg10130564 chr11:117069849 TAGLN -0.33 -5.69 -0.3 2.82e-8 Blood protein levels; LUSC cis rs11630290 0.613 rs925251 chr15:64175124 C/G cg12036633 chr15:63758958 NA 0.51 6.43 0.33 4.34e-10 Iris characteristics; LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg25767906 chr1:53392781 SCP2 -0.64 -12.71 -0.57 1.89e-30 Monocyte count; LUSC cis rs1775715 0.870 rs1775731 chr10:32253512 A/G cg03015672 chr10:32216066 ARHGAP12 0.33 5.66 0.3 3.31e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7553864 0.667 rs6576866 chr1:87601471 T/C cg17420885 chr1:87600446 LOC339524 -0.46 -6.28 -0.33 1.05e-9 Smoking behavior; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg10729496 chr3:10149963 C3orf24 0.56 7.11 0.36 7.2e-12 Alzheimer's disease; LUSC cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg04511125 chr2:88470314 THNSL2 0.68 6.42 0.33 4.76e-10 Plasma clusterin levels; LUSC cis rs7824557 0.527 rs57629785 chr8:11235150 C/A cg21775007 chr8:11205619 TDH -0.65 -10.34 -0.49 6.55e-22 Retinal vascular caliber; LUSC cis rs1113500 0.548 rs6583062 chr1:108656463 G/A cg11967332 chr1:108735228 SLC25A24 0.44 5.95 0.31 6.7e-9 Growth-regulated protein alpha levels; LUSC cis rs469568 0.935 rs468723 chr5:178667778 A/G cg08999896 chr5:178685787 ADAMTS2 0.3 6.19 0.32 1.72e-9 Stroke (pediatric); LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.38 0.37 1.3e-12 Bipolar disorder; LUSC cis rs4631830 0.896 rs7077830 chr10:51522276 C/G cg16070123 chr10:51489643 NA 0.48 7.75 0.39 1.11e-13 Prostate-specific antigen levels; LUSC cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg06026331 chr20:60912101 LAMA5 0.56 6.73 0.35 7.56e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.11 0.52 1.27e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs4660306 1.000 rs11211132 chr1:45990516 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.53 -0.34 2.48e-10 Homocysteine levels; LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg27170947 chr2:26402098 FAM59B -0.7 -10.61 -0.5 7.11e-23 Gut microbiome composition (summer); LUSC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg04111992 chr7:158790115 NA 0.35 5.7 0.3 2.64e-8 Facial morphology (factor 20); LUSC cis rs11622475 1.000 rs7143682 chr14:104413455 C/T cg12183467 chr14:104352244 NA -0.43 -7.68 -0.39 1.82e-13 Bipolar disorder; LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg14433983 chr11:636460 DRD4 -0.35 -5.88 -0.31 9.78e-9 Systemic lupus erythematosus; LUSC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs34375054 0.525 rs1080910 chr12:125608492 T/C cg25124228 chr12:125621409 AACS -0.6 -9.98 -0.48 1.06e-20 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg13010199 chr12:38710504 ALG10B 0.68 10.71 0.51 3.28e-23 Bladder cancer; LUSC cis rs3809566 0.963 rs4775608 chr15:63331940 A/G cg05507819 chr15:63340323 TPM1 0.64 8.98 0.44 1.95e-17 Platelet count; LUSC cis rs6960043 1.000 rs6962498 chr7:15050305 C/G cg19272540 chr7:15055459 NA -0.31 -7.41 -0.38 1.01e-12 Type 2 diabetes; LUSC cis rs76419734 0.510 rs2544417 chr4:106745405 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.54 -6.0 -0.31 5.21e-9 Post bronchodilator FEV1; LUSC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg04248312 chr19:17393744 ANKLE1 -0.98 -16.45 -0.67 6.2e-45 Systemic lupus erythematosus; LUSC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs9323205 0.871 rs2999393 chr14:51655167 G/T cg23942311 chr14:51606299 NA 0.4 8.15 0.41 7.36e-15 Cancer; LUSC cis rs9640161 0.659 rs59572505 chr7:150014986 C/T cg17279839 chr7:150038598 RARRES2 0.44 6.9 0.35 2.6e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs4285028 0.747 rs1127412 chr3:121414061 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.88 -12.4 -0.56 2.65e-29 Multiple sclerosis; LUSC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg22029157 chr1:209979665 IRF6 0.76 11.16 0.52 8.66e-25 Cleft lip with or without cleft palate; LUSC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs9653442 0.900 rs2309837 chr2:100837567 T/C cg22139774 chr2:100720529 AFF3 -0.45 -7.9 -0.4 3.97e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 0.31 5.9 0.31 9.05e-9 Schizophrenia; LUSC trans rs1499614 0.803 rs1796229 chr7:66119661 G/A cg10756647 chr7:56101905 PSPH 0.88 8.96 0.44 2.32e-17 Gout; LUSC cis rs10904908 1.000 rs7920112 chr10:17259863 T/C cg01003015 chr10:17271136 VIM -0.42 -6.04 -0.31 4.02e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.72 0.51 3.01e-23 Bone mineral density; LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg16362232 chr11:430036 ANO9 0.64 8.17 0.41 6.27e-15 Body mass index; LUSC cis rs73200209 0.744 rs56869346 chr12:116514538 T/C cg01776926 chr12:116560359 MED13L -0.49 -6.03 -0.31 4.4e-9 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19164917 chr7:99102197 ZKSCAN5 -0.42 -6.23 -0.32 1.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6599077 1.000 rs9870930 chr3:40097971 A/G cg13683864 chr3:40499215 RPL14 -0.61 -7.25 -0.37 2.94e-12 Sleep-related phenotypes; LUSC trans rs2235573 0.527 rs139866 chr22:38354684 C/T cg19894588 chr14:64061835 NA 0.54 7.74 0.39 1.19e-13 Glioblastoma;Glioma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08031094 chr2:54013912 LOC100302652;ASB3;ERLEC1 0.41 6.13 0.32 2.44e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs208515 0.525 rs10498841 chr6:66663706 C/T cg07460842 chr6:66804631 NA 1.02 13.75 0.6 2.16e-34 Exhaled nitric oxide levels; LUSC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.65e-8 Diabetic kidney disease; LUSC cis rs5769765 0.908 rs138889 chr22:50226673 T/C cg08270630 chr22:50330655 NA -0.41 -6.19 -0.32 1.79e-9 Schizophrenia; LUSC cis rs7615952 0.932 rs13065725 chr3:125632289 C/A cg05084668 chr3:125655381 ALG1L -0.79 -11.78 -0.54 4.85e-27 Blood pressure (smoking interaction); LUSC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg02187348 chr16:89574699 SPG7 0.61 10.07 0.48 5.4e-21 Multiple myeloma (IgH translocation); LUSC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 7.78 0.39 9.16e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs7520050 0.807 rs6656279 chr1:46124088 C/G cg24296786 chr1:45957014 TESK2 -0.41 -5.81 -0.3 1.47e-8 Red blood cell count;Reticulocyte count; LUSC cis rs6570726 0.935 rs413916 chr6:145831400 T/C cg23711669 chr6:146136114 FBXO30 0.75 13.32 0.59 9.55e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg01884057 chr2:25150051 NA 0.48 11.43 0.53 9.67e-26 Body mass index; LUSC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg23281280 chr6:28129359 ZNF389 0.43 5.67 0.3 3.04e-8 Depression; LUSC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg11764359 chr7:65958608 NA 0.79 12.84 0.57 5.82e-31 Aortic root size; LUSC cis rs9322817 0.625 rs2499655 chr6:105307435 G/A cg02098413 chr6:105308735 HACE1 0.27 5.8 0.3 1.52e-8 Thyroid stimulating hormone; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg25428297 chr7:1022841 CYP2W1 0.28 5.66 0.3 3.22e-8 Longevity;Endometriosis; LUSC cis rs9677476 0.863 rs58383275 chr2:232063946 T/C cg07929768 chr2:232055508 NA 0.37 6.85 0.35 3.49e-11 Food antigen IgG levels; LUSC cis rs2439831 0.850 rs28858500 chr15:44156942 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.84 0.44 5.76e-17 Lung cancer in ever smokers; LUSC cis rs1975974 0.872 rs17052344 chr17:21717543 A/G cg18423549 chr17:21743878 NA 0.53 7.96 0.4 2.63e-14 Psoriasis; LUSC cis rs1371867 0.846 rs1660332 chr8:101309490 A/G cg06636551 chr8:101224915 SPAG1 0.39 7.26 0.37 2.82e-12 Atrioventricular conduction; LUSC cis rs7804356 0.953 rs10241234 chr7:26869887 T/A cg03456212 chr7:26904342 SKAP2 -0.56 -6.46 -0.33 3.63e-10 Type 1 diabetes; LUSC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg16447950 chr5:562315 NA -0.53 -6.6 -0.34 1.63e-10 Obesity-related traits; LUSC cis rs2742417 1.000 rs2251954 chr3:45731784 A/G cg09608765 chr3:45636137 LIMD1 -0.33 -6.47 -0.33 3.47e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs1670533 1.000 rs4690212 chr4:1054898 T/C cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg13770153 chr20:60521292 NA -0.65 -9.13 -0.45 6.8e-18 Body mass index; LUSC cis rs2070433 0.539 rs1008549 chr21:47959698 C/T cg12379764 chr21:47803548 PCNT 0.79 12.27 0.56 8.16e-29 Lymphocyte counts; LUSC cis rs7107174 0.901 rs2450136 chr11:77925273 T/G cg02023728 chr11:77925099 USP35 0.54 7.76 0.39 1.03e-13 Testicular germ cell tumor; LUSC cis rs10992471 0.651 rs7043984 chr9:95529408 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.69 -0.34 9.49e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs72781680 0.846 rs55707417 chr2:24029928 G/A cg08917208 chr2:24149416 ATAD2B 0.96 10.09 0.48 4.61e-21 Lymphocyte counts; LUSC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.41 0.38 1.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.14 0.32 2.31e-9 Schizophrenia; LUSC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg11764359 chr7:65958608 NA -0.7 -10.65 -0.5 5.29e-23 Aortic root size; LUSC cis rs308403 0.640 rs34518478 chr4:123719999 T/G cg10495464 chr4:123653540 BBS12;LOC729338 0.82 10.23 0.49 1.5e-21 Blood protein levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17227680 chr17:46048473 CDK5RAP3 0.78 6.7 0.34 8.69e-11 Cognitive performance; LUSC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg21951975 chr1:209979733 IRF6 0.52 7.44 0.38 8.83e-13 Cleft lip with or without cleft palate; LUSC cis rs7572644 0.713 rs1458397 chr2:28219608 T/C cg27432699 chr2:27873401 GPN1 -0.52 -6.45 -0.33 3.97e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4474465 0.688 rs4277140 chr11:78285096 G/T cg27205649 chr11:78285834 NARS2 -0.54 -6.69 -0.34 9.39e-11 Alzheimer's disease (survival time); LUSC cis rs892961 0.932 rs11650011 chr17:75412334 A/G cg05865280 chr17:75406074 SEPT9 0.45 9.66 0.47 1.23e-19 Airflow obstruction; LUSC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg21951975 chr1:209979733 IRF6 0.57 8.52 0.42 5.74e-16 Cleft lip with or without cleft palate; LUSC cis rs11758351 0.778 rs41266801 chr6:26197493 C/A cg11342453 chr6:26196699 NA 0.54 5.67 0.3 3.13e-8 Gout;Renal underexcretion gout; LUSC cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg16482183 chr6:26056742 HIST1H1C 0.47 6.82 0.35 4.37e-11 Height; LUSC cis rs4478858 0.735 rs10798843 chr1:31797094 A/G cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs4654899 1.000 rs6682368 chr1:21506914 G/A cg01072550 chr1:21505969 NA -0.55 -8.49 -0.42 7e-16 Superior frontal gyrus grey matter volume; LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg18402987 chr7:1209562 NA 0.73 7.92 0.4 3.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9486719 1.000 rs12190508 chr6:96898269 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs12989701 0.877 rs12994718 chr2:127874226 T/A cg08168897 chr2:127865431 BIN1 0.71 9.36 0.46 1.2e-18 Alzheimer's disease (late onset); LUSC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg00999904 chr2:3704751 ALLC -0.44 -6.76 -0.35 6.12e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs9291683 0.609 rs12500810 chr4:10031068 G/A cg26043149 chr18:55253948 FECH 0.51 7.53 0.38 4.93e-13 Bone mineral density; LUSC trans rs4843747 0.641 rs11117353 chr16:88090895 A/G cg26811252 chr16:29126840 RRN3P2 0.63 9.89 0.48 2.18e-20 Menopause (age at onset); LUSC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg04315214 chr1:2043799 PRKCZ 0.48 9.96 0.48 1.29e-20 Height; LUSC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg20203395 chr5:56204925 C5orf35 -0.47 -6.89 -0.35 2.72e-11 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18251222 chr2:10183620 KLF11 0.51 6.85 0.35 3.64e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6089584 0.507 rs6061999 chr20:60637429 G/A cg24733560 chr20:60626293 TAF4 0.43 7.85 0.39 5.57e-14 Body mass index; LUSC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg23649088 chr2:200775458 C2orf69 -0.53 -7.17 -0.37 4.94e-12 Schizophrenia; LUSC cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg17420585 chr12:42539391 GXYLT1 -0.38 -7.51 -0.38 5.57e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1775715 0.769 rs2808102 chr10:32117749 A/T cg03015672 chr10:32216066 ARHGAP12 0.35 6.15 0.32 2.23e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7712401 0.562 rs30052 chr5:122305009 A/T cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.59 -8.67 -0.43 1.95e-16 Monocyte percentage of white cells; LUSC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg08847533 chr14:75593920 NEK9 0.79 13.45 0.59 2.99e-33 Height; LUSC cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs5769707 0.935 rs9616332 chr22:50047678 C/G cg05373962 chr22:49881684 NA -0.44 -10.56 -0.5 1.13e-22 Monocyte count;Monocyte percentage of white cells; LUSC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.82 -0.35 4.21e-11 Aortic root size; LUSC cis rs8060686 0.641 rs8044014 chr16:68209872 T/C cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg15423357 chr2:25149977 NA -0.39 -7.83 -0.39 6.4e-14 Body mass index; LUSC cis rs16976116 0.901 rs8027098 chr15:55492269 C/T cg11288833 chr15:55489084 RSL24D1 0.49 5.87 0.31 1.06e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1451375 1.000 rs921450 chr7:50623260 A/G cg18232548 chr7:50535776 DDC -0.51 -7.83 -0.39 6.32e-14 Malaria; LUSC cis rs7647973 0.593 rs1799844 chr3:49847642 G/A cg03060546 chr3:49711283 APEH -0.63 -7.36 -0.37 1.49e-12 Menarche (age at onset); LUSC cis rs1023500 0.573 rs133377 chr22:42466950 C/T cg15557168 chr22:42548783 NA -0.47 -7.33 -0.37 1.73e-12 Schizophrenia; LUSC trans rs11098499 0.865 rs10213221 chr4:120255926 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.47e-10 Corneal astigmatism; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.28 0.56 7.31e-29 Prudent dietary pattern; LUSC cis rs727505 1.000 rs10244817 chr7:124467470 T/C cg23710748 chr7:124431027 NA -0.42 -7.66 -0.39 2.06e-13 Lewy body disease; LUSC cis rs6089584 0.546 rs4925337 chr20:60637637 T/C cg24733560 chr20:60626293 TAF4 0.41 7.35 0.37 1.58e-12 Body mass index; LUSC cis rs7246967 0.673 rs34795935 chr19:22865188 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs1044826 1.000 rs114427693 chr3:139121721 G/A cg00490450 chr3:139108681 COPB2 0.55 7.32 0.37 1.82e-12 Obesity-related traits; LUSC cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg00071950 chr4:10020882 SLC2A9 -0.61 -10.12 -0.48 3.47e-21 Bone mineral density; LUSC cis rs2274273 0.870 rs59629906 chr14:55781189 T/C cg04306507 chr14:55594613 LGALS3 0.54 11.81 0.54 3.97e-27 Protein biomarker; LUSC cis rs137603 0.644 rs137621 chr22:39710244 G/A cg17798944 chr22:39715225 SNORD43;RPL3 -0.52 -8.22 -0.41 4.71e-15 Primary biliary cholangitis; LUSC cis rs11785400 0.793 rs10956992 chr8:143736235 A/C cg10596483 chr8:143751796 JRK 0.53 7.66 0.39 1.98e-13 Schizophrenia; LUSC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg04034577 chr2:241836375 C2orf54 -0.49 -9.19 -0.45 4.31e-18 Urinary metabolites; LUSC cis rs7927771 0.864 rs4752838 chr11:47466006 G/A cg05585544 chr11:47624801 NA -0.41 -7.02 -0.36 1.21e-11 Subjective well-being; LUSC cis rs6690583 0.623 rs55721024 chr1:85454447 A/C cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.02e-10 Serum sulfate level; LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg07092213 chr7:1199455 ZFAND2A -0.42 -6.68 -0.34 1e-10 Longevity;Endometriosis; LUSC cis rs62384625 1.000 rs17208670 chr5:141497239 A/G cg23435118 chr5:141488016 NDFIP1 0.35 6.06 0.31 3.74e-9 White blood cell count (basophil); LUSC cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg02466173 chr16:30829666 NA -0.58 -10.9 -0.51 7.02e-24 Multiple myeloma; LUSC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs11792861 0.926 rs10512391 chr9:111809530 A/G cg05043794 chr9:111880884 C9orf5 -0.3 -6.34 -0.33 7.54e-10 Menarche (age at onset); LUSC cis rs2932538 0.961 rs2932539 chr1:113215786 A/G cg22162597 chr1:113214053 CAPZA1 -0.68 -9.7 -0.47 9.01e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs9467773 0.587 rs12214031 chr6:26376628 T/C cg05738196 chr6:26577821 NA -0.5 -7.61 -0.38 2.89e-13 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.534 rs9356551 chr6:167400345 T/C cg23791538 chr6:167370224 RNASET2 0.5 8.27 0.41 3.19e-15 Crohn's disease; LUSC cis rs2073300 1.000 rs6048835 chr20:23462343 G/C cg09953122 chr20:23471693 CST8 -0.76 -7.49 -0.38 6.37e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs354225 0.513 rs10187338 chr2:54806611 A/G cg26097391 chr2:54893211 SPTBN1 0.42 6.39 0.33 5.6e-10 Schizophrenia; LUSC cis rs1044826 1.000 rs12494806 chr3:139067595 G/A cg00490450 chr3:139108681 COPB2 0.57 7.61 0.38 2.77e-13 Obesity-related traits; LUSC cis rs727505 0.607 rs17387389 chr7:124784751 T/C cg23710748 chr7:124431027 NA -0.39 -6.95 -0.36 1.93e-11 Lewy body disease; LUSC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg11752832 chr7:134001865 SLC35B4 0.52 8.01 0.4 1.89e-14 Mean platelet volume; LUSC cis rs1941023 0.503 rs11230288 chr11:60128968 G/A cg08716584 chr11:60157161 MS4A7 -0.61 -11.47 -0.53 6.92e-26 Congenital heart disease (maternal effect); LUSC cis rs9341808 0.754 rs978814 chr6:80959912 G/T cg08355045 chr6:80787529 NA 0.56 9.61 0.47 1.84e-19 Sitting height ratio; LUSC cis rs8072100 0.811 rs1912483 chr17:45443494 A/G cg25173405 chr17:45401733 C17orf57 -0.39 -5.92 -0.31 7.86e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11190604 1.000 rs11190589 chr10:102275471 A/G cg23241863 chr10:102295624 HIF1AN 0.49 6.07 0.32 3.38e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1957429 0.808 rs2357866 chr14:65336517 C/T cg23373153 chr14:65346875 NA 0.97 10.99 0.52 3.53e-24 Pediatric areal bone mineral density (radius); LUSC cis rs2963155 0.518 rs853179 chr5:142634773 G/T cg17617527 chr5:142782415 NR3C1 0.71 8.42 0.42 1.14e-15 Breast cancer; LUSC cis rs590121 0.876 rs650241 chr11:75277757 C/G cg26104986 chr11:75275303 SERPINH1 -0.29 -6.06 -0.31 3.74e-9 Coronary artery disease; LUSC cis rs796364 0.507 rs13035874 chr2:201109553 G/A cg04283868 chr2:201171347 SPATS2L 0.45 6.05 0.31 3.99e-9 Schizophrenia; LUSC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 8.84 0.44 5.48e-17 Schizophrenia; LUSC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg07212818 chr11:638076 DRD4 -0.41 -7.05 -0.36 1e-11 Systemic lupus erythematosus; LUSC cis rs6088580 0.524 rs6088565 chr20:33254986 A/C cg08999081 chr20:33150536 PIGU -0.36 -6.46 -0.33 3.62e-10 Glomerular filtration rate (creatinine); LUSC cis rs9479482 1.000 rs9479405 chr6:150338065 G/A cg25797454 chr6:150327115 RAET1K 0.37 8.48 0.42 7.48e-16 Alopecia areata; LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg22907277 chr7:1156413 C7orf50 0.68 8.11 0.41 9.63e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12950390 0.853 rs28589850 chr17:45855713 A/G cg06532163 chr17:45867833 NA 0.34 6.33 0.33 8.11e-10 IgG glycosylation; LUSC trans rs61931739 0.853 rs10844751 chr12:34099651 T/G cg26384229 chr12:38710491 ALG10B -0.58 -9.32 -0.45 1.69e-18 Morning vs. evening chronotype; LUSC cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs2295359 0.892 rs11209004 chr1:67613932 G/A cg03340356 chr1:67600835 NA 0.43 6.75 0.35 6.57e-11 Psoriasis; LUSC cis rs870825 0.860 rs34985821 chr4:185599489 G/A cg04058563 chr4:185651563 MLF1IP 0.84 11.85 0.54 2.72e-27 Blood protein levels; LUSC cis rs2677744 0.626 rs11857545 chr15:91489705 G/A cg23684204 chr15:91497937 RCCD1 0.53 7.33 0.37 1.73e-12 Attention deficit hyperactivity disorder; LUSC cis rs1448094 0.967 rs10779222 chr12:86330775 G/A cg00310523 chr12:86230176 RASSF9 0.4 7.33 0.37 1.8e-12 Major depressive disorder; LUSC cis rs16976116 0.806 rs117064453 chr15:55492319 T/A cg11288833 chr15:55489084 RSL24D1 0.5 5.88 0.31 1.02e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs55665837 0.961 rs60622588 chr11:14456998 T/C cg05501817 chr11:14380813 RRAS2 -0.41 -6.53 -0.34 2.5e-10 Vitamin D levels; LUSC cis rs669446 0.533 rs2158956 chr1:44211697 T/C cg15962314 chr1:44399869 ARTN 0.24 5.66 0.3 3.33e-8 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs1775715 0.707 rs2065443 chr10:32164236 C/G cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.62e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg00310523 chr12:86230176 RASSF9 0.47 8.62 0.43 2.74e-16 Major depressive disorder; LUSC cis rs4423214 0.592 rs10898191 chr11:71194601 G/A cg05163923 chr11:71159392 DHCR7 -0.66 -7.09 -0.36 8.08e-12 Vitamin D levels; LUSC cis rs1506636 1.000 rs767637 chr7:123321978 C/A cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs35883536 0.647 rs2783703 chr1:101040794 T/C cg06223162 chr1:101003688 GPR88 0.49 9.44 0.46 6.6e-19 Monocyte count; LUSC cis rs6754311 0.551 rs6739713 chr2:136488978 A/G cg07169764 chr2:136633963 MCM6 0.58 7.42 0.38 9.99e-13 Mosquito bite size; LUSC cis rs7364180 0.515 rs6002503 chr22:42208672 A/G cg03806693 chr22:41940476 POLR3H -0.63 -9.57 -0.46 2.46e-19 Alzheimer's disease biomarkers; LUSC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg18225595 chr11:63971243 STIP1 0.47 5.98 0.31 5.86e-9 Mean platelet volume; LUSC trans rs72674100 1.000 rs28520218 chr4:97966557 T/C cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg00152838 chr16:24741724 TNRC6A -0.46 -5.69 -0.3 2.74e-8 Intelligence (multi-trait analysis); LUSC cis rs6669919 0.530 rs11587621 chr1:211668400 C/T cg10512769 chr1:211675356 NA 0.28 6.71 0.34 8.34e-11 Intelligence (multi-trait analysis); LUSC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.62 -8.86 -0.44 4.81e-17 Mean platelet volume; LUSC cis rs6076065 0.748 rs2424542 chr20:23386800 C/T cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg00509249 chr6:109615579 CCDC162 0.32 5.79 0.3 1.61e-8 Reticulocyte fraction of red cells; LUSC cis rs1018836 0.923 rs11784529 chr8:91640956 C/A cg16814680 chr8:91681699 NA -0.76 -12.62 -0.57 3.87e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs13253111 0.603 rs28605937 chr8:28099179 A/G cg26534493 chr8:28060551 NA 0.37 6.78 0.35 5.48e-11 Childhood body mass index; LUSC cis rs427394 1.000 rs427394 chr5:6745875 A/G cg10857441 chr5:6722123 POLS -0.4 -7.55 -0.38 4.2e-13 Menopause (age at onset); LUSC cis rs4704187 0.687 rs7735937 chr5:74441700 G/A cg03227963 chr5:74354835 NA 0.31 6.63 0.34 1.35e-10 Response to amphetamines; LUSC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg07211511 chr3:129823064 LOC729375 -1.24 -20.25 -0.74 4.86e-60 Blood pressure (smoking interaction); LUSC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg24675658 chr1:53192096 ZYG11B -0.64 -10.02 -0.48 7.94e-21 Monocyte count; LUSC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg15556689 chr8:8085844 FLJ10661 -0.57 -8.67 -0.43 1.97e-16 Joint mobility (Beighton score); LUSC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg16743903 chr16:89593216 SPG7 -0.38 -5.88 -0.31 9.98e-9 Multiple myeloma (IgH translocation); LUSC cis rs6940638 0.513 rs4424065 chr6:27036456 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.31 -6.16 -0.32 2.07e-9 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 3.1e-34 Prudent dietary pattern; LUSC cis rs7824557 0.527 rs2572449 chr8:11239137 A/G cg12568669 chr8:11666485 FDFT1 -0.24 -5.66 -0.3 3.24e-8 Retinal vascular caliber; LUSC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg24562669 chr7:97807699 LMTK2 0.33 5.75 0.3 1.99e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC trans rs7819412 0.645 rs10156356 chr8:11046209 T/C cg15556689 chr8:8085844 FLJ10661 -0.51 -7.33 -0.37 1.78e-12 Triglycerides; LUSC cis rs3947 0.687 rs1736065 chr8:11685453 A/G cg00262122 chr8:11665843 FDFT1 -0.47 -5.86 -0.31 1.08e-8 Blood protein levels; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg01125463 chr6:42946178 PEX6 -0.34 -5.66 -0.3 3.19e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs865483 0.895 rs7501983 chr17:35783812 A/G cg06716730 chr17:35851459 DUSP14 -0.26 -5.73 -0.3 2.2e-8 Monocyte count; LUSC cis rs6547741 1.000 rs7604798 chr2:27824940 T/C cg12559939 chr2:27858050 GPN1 0.41 6.44 0.33 4.16e-10 Oral cavity cancer; LUSC cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs190945449 1 rs190945449 chr6:26828359 C/T cg06606381 chr12:133084897 FBRSL1 -0.84 -7.64 -0.39 2.38e-13 Urinary tract infection frequency; LUSC cis rs9650657 0.537 rs7016385 chr8:10779472 A/G cg27411982 chr8:10470053 RP1L1 0.47 7.06 0.36 9.53e-12 Neuroticism; LUSC cis rs921968 0.565 rs6436070 chr2:219597960 A/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.08 -0.48 4.89e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs7903847 0.619 rs10882912 chr10:99138077 C/T cg20016023 chr10:99160130 RRP12 -0.34 -8.25 -0.41 3.65e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs983392 0.680 rs7929589 chr11:59975078 C/T cg02771260 chr11:59836817 MS4A3 -0.37 -5.96 -0.31 6.25e-9 Alzheimer's disease (late onset); LUSC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.05 0.31 3.81e-9 Schizophrenia; LUSC cis rs7100689 0.577 rs10749551 chr10:82054001 A/C cg01528321 chr10:82214614 TSPAN14 0.94 14.4 0.62 6.41e-37 Post bronchodilator FEV1; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 12.94 0.58 2.61e-31 Platelet count; LUSC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg26314531 chr2:26401878 FAM59B 0.71 9.73 0.47 7.41e-20 Gut microbiome composition (summer); LUSC cis rs62481355 0.680 rs11563620 chr7:127059236 C/T cg25922125 chr7:127225783 GCC1 -0.42 -5.73 -0.3 2.29e-8 Type 2 diabetes; LUSC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg24838063 chr12:130822603 PIWIL1 0.69 10.79 0.51 1.69e-23 Menopause (age at onset); LUSC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg25767906 chr1:53392781 SCP2 0.45 7.9 0.4 4.06e-14 Monocyte count; LUSC cis rs4731207 0.594 rs6968500 chr7:124431722 G/C cg14311320 chr7:124405732 GPR37 -0.32 -6.01 -0.31 4.81e-9 Cutaneous malignant melanoma; LUSC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg11062466 chr8:58055876 NA -0.74 -8.91 -0.44 3.31e-17 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg24813613 chr7:1882135 MAD1L1 -0.35 -5.71 -0.3 2.52e-8 Bipolar disorder and schizophrenia; LUSC cis rs7833986 0.501 rs72653957 chr8:56990048 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.25 0.56 9.59e-29 Height; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg27588902 chr6:42928151 GNMT -0.3 -6.56 -0.34 2e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg24503407 chr1:205819492 PM20D1 -0.44 -6.07 -0.32 3.47e-9 Parkinson's disease; LUSC cis rs77140172 0.677 rs77860352 chr4:89627774 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 1.0 7.48 0.38 6.84e-13 Post bronchodilator FEV1; LUSC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.43 -7.23 -0.37 3.3e-12 Hip circumference adjusted for BMI; LUSC cis rs4919087 1.000 rs7076523 chr10:99089296 T/C cg25902810 chr10:99078978 FRAT1 -0.46 -6.66 -0.34 1.15e-10 Monocyte count; LUSC cis rs2075671 0.903 rs11760602 chr7:100264128 G/C cg00334542 chr7:100209784 MOSPD3 -0.49 -5.74 -0.3 2.11e-8 Other erythrocyte phenotypes; LUSC cis rs6690583 0.623 rs12047435 chr1:85452927 T/G cg22153463 chr1:85462885 MCOLN2 0.63 6.0 0.31 5.24e-9 Serum sulfate level; LUSC trans rs9929218 1.000 rs13334471 chr16:68800452 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.53 -0.53 4.11e-26 Colorectal cancer; LUSC cis rs4792901 0.685 rs9898065 chr17:41562473 T/G cg22562494 chr17:41607896 ETV4 -0.33 -6.34 -0.33 7.62e-10 Dupuytren's disease; LUSC cis rs2237234 0.542 rs7755997 chr6:26483048 G/A cg09904177 chr6:26538194 HMGN4 0.5 7.74 0.39 1.21e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg21906852 chr1:75198582 TYW3;CRYZ 0.37 5.72 0.3 2.32e-8 Resistin levels; LUSC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg17330251 chr7:94953956 PON1 -0.37 -5.86 -0.31 1.1e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs724744 0.742 rs1205934 chr6:22358196 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg03188948 chr7:1209495 NA 0.67 7.1 0.36 7.38e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg27284194 chr4:1044797 NA 0.36 5.98 0.31 5.86e-9 Obesity-related traits; LUSC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg22508957 chr16:3507546 NAT15 0.64 10.6 0.5 7.9399999999999994e-23 Tuberculosis; LUSC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg20203395 chr5:56204925 C5orf35 -0.46 -6.85 -0.35 3.61e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg24549020 chr5:56110836 MAP3K1 0.47 5.69 0.3 2.83e-8 Initial pursuit acceleration; LUSC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg06637938 chr14:75390232 RPS6KL1 0.52 8.26 0.41 3.33e-15 Height; LUSC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg11764359 chr7:65958608 NA 0.71 11.19 0.52 6.78e-25 Aortic root size; LUSC cis rs7246967 0.673 rs34425596 chr19:22899779 T/C cg23217946 chr19:22817039 ZNF492 0.41 5.69 0.3 2.85e-8 Bronchopulmonary dysplasia; LUSC trans rs1493916 0.905 rs34910379 chr18:31400047 A/G cg15819921 chr19:927150 ARID3A -0.42 -6.19 -0.32 1.79e-9 Life satisfaction; LUSC cis rs983392 0.805 rs7933805 chr11:59967526 A/G cg02771260 chr11:59836817 MS4A3 -0.36 -5.86 -0.31 1.11e-8 Alzheimer's disease (late onset); LUSC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg24450063 chr1:156163899 SLC25A44 1.21 30.68 0.86 3.34e-99 Testicular germ cell tumor; LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg10802521 chr3:52805072 NEK4 -0.52 -7.65 -0.39 2.12e-13 Bipolar disorder; LUSC cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg23711669 chr6:146136114 FBXO30 0.88 16.35 0.67 1.48e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs10911232 0.507 rs4422969 chr1:183020762 G/A ch.1.3577855R chr1:183094577 LAMC1 0.7 10.9 0.51 6.98e-24 Hypertriglyceridemia; LUSC cis rs868036 0.609 rs28742003 chr15:68127769 C/T cg24579218 chr15:68104479 NA -0.4 -6.29 -0.33 9.87e-10 Restless legs syndrome; LUSC cis rs9650657 0.538 rs11250093 chr8:10798828 C/T cg21775007 chr8:11205619 TDH 0.44 5.95 0.31 6.59e-9 Neuroticism; LUSC cis rs16910800 1.000 rs2468646 chr11:23202166 T/C cg20040320 chr11:23191996 NA 0.44 6.47 0.33 3.59e-10 Cancer; LUSC cis rs2692947 0.726 rs13009727 chr2:96769883 C/G cg23100626 chr2:96804247 ASTL -0.26 -6.36 -0.33 6.54e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg12560992 chr17:57184187 TRIM37 0.85 15.53 0.65 2.58e-41 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs6754311 0.861 rs12475139 chr2:136786651 A/T cg07169764 chr2:136633963 MCM6 0.48 6.63 0.34 1.33e-10 Mosquito bite size; LUSC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg09796270 chr17:17721594 SREBF1 0.43 7.6 0.38 2.97e-13 Total body bone mineral density; LUSC cis rs8114671 0.836 rs4911461 chr20:33629993 A/C cg24642439 chr20:33292090 TP53INP2 -0.4 -5.76 -0.3 1.92e-8 Height; LUSC cis rs79839061 0.610 rs62297062 chr4:869698 C/T cg07828340 chr4:882639 GAK 1.07 11.34 0.53 1.99e-25 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg12927641 chr6:109611667 NA -0.36 -6.13 -0.32 2.46e-9 Reticulocyte fraction of red cells; LUSC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs73001065 0.636 rs73002960 chr19:19582992 C/T cg03709012 chr19:19516395 GATAD2A 0.95 8.57 0.42 3.78e-16 LDL cholesterol; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg25703541 chr22:24373054 LOC391322 0.84 12.95 0.58 2.31e-31 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg15556689 chr8:8085844 FLJ10661 0.48 6.87 0.35 3.22e-11 Recombination measurement; LUSC cis rs921968 0.643 rs3845836 chr2:219504955 C/T cg02176678 chr2:219576539 TTLL4 0.59 10.78 0.51 1.92e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs7804356 1.000 rs7791513 chr7:26893357 A/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.13 -0.32 2.54e-9 Type 1 diabetes; LUSC cis rs6088590 0.550 rs12624640 chr20:32952125 G/A cg08999081 chr20:33150536 PIGU 0.43 7.43 0.38 9.41e-13 Coronary artery disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05019311 chr17:4807065 CHRNE -0.47 -6.04 -0.31 4.1e-9 Hepatitis; LUSC cis rs12478296 0.901 rs67951957 chr2:243004901 A/G cg06360820 chr2:242988706 NA -0.83 -9.66 -0.47 1.25e-19 Obesity-related traits; LUSC cis rs113835537 0.529 rs3892818 chr11:66240191 C/T cg24851651 chr11:66362959 CCS 0.56 8.77 0.43 9.26e-17 Airway imaging phenotypes; LUSC cis rs6964587 0.869 rs405 chr7:91546327 G/C cg17063962 chr7:91808500 NA -0.51 -7.84 -0.39 6.22e-14 Breast cancer; LUSC cis rs7937682 0.889 rs487985 chr11:111517908 G/A cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs9790314 0.875 rs7615592 chr3:160981548 A/C cg03342759 chr3:160939853 NMD3 -0.49 -8.15 -0.41 7.57e-15 Morning vs. evening chronotype; LUSC cis rs4690686 0.509 rs11730559 chr4:177259257 A/T cg17059388 chr4:177262070 NA 0.44 7.95 0.4 2.9e-14 Essential tremor; LUSC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg21856205 chr7:94953877 PON1 -0.36 -5.73 -0.3 2.29e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg05564831 chr3:52568323 NT5DC2 0.37 6.76 0.35 6.06e-11 Electroencephalogram traits; LUSC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.18 0.32 1.87e-9 Height; LUSC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs13392177 0.672 rs1877715 chr2:219052546 C/T cg00012203 chr2:219082015 ARPC2 0.8 13.84 0.6 9.57e-35 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg13852791 chr20:30311386 BCL2L1 0.82 10.86 0.51 9.72e-24 Mean corpuscular hemoglobin; LUSC trans rs12210905 0.614 rs12199685 chr6:27323486 G/A cg02699829 chr19:13216355 TRMT1 -0.56 -6.23 -0.32 1.39e-9 Hip circumference adjusted for BMI; LUSC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg15704280 chr7:45808275 SEPT13 1.0 17.03 0.68 2.91e-47 Coronary artery disease; LUSC cis rs67397200 0.590 rs12327712 chr19:17424947 T/G cg04248312 chr19:17393744 ANKLE1 -0.41 -5.99 -0.31 5.52e-9 Breast cancer;Breast Cancer in BRCA1 mutation carriers;Breast cancer (estrogen-receptor negative); LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg19266014 chr7:2183958 MAD1L1 -0.34 -5.73 -0.3 2.26e-8 Bipolar disorder and schizophrenia; LUSC cis rs7107174 0.688 rs11237489 chr11:78130325 G/A cg27205649 chr11:78285834 NARS2 -0.51 -5.87 -0.31 1.04e-8 Testicular germ cell tumor; LUSC cis rs1577917 1.000 rs10944161 chr6:86630376 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg21643547 chr1:205240462 TMCC2 -0.5 -9.31 -0.45 1.7e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg19774624 chr17:42201019 HDAC5 -0.81 -12.99 -0.58 1.61e-31 Total body bone mineral density; LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.932 rs417110 chr20:25458297 T/C cg08601574 chr20:25228251 PYGB 0.41 6.25 0.32 1.22e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6696846 0.765 rs72757524 chr1:205086473 C/T cg00857998 chr1:205179979 DSTYK 0.65 10.16 0.49 2.65e-21 Red blood cell count; LUSC cis rs62400317 0.859 rs4443508 chr6:45235952 C/T cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg23711669 chr6:146136114 FBXO30 0.82 14.65 0.63 7.15e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs12541635 0.677 rs12546875 chr8:107012915 C/T cg10147462 chr8:107024639 NA 0.68 14.28 0.62 1.94e-36 Age of smoking initiation; LUSC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg24531977 chr5:56204891 C5orf35 1.07 15.55 0.65 2.08e-41 Initial pursuit acceleration; LUSC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg21724239 chr8:58056113 NA 0.73 8.03 0.4 1.73e-14 Developmental language disorder (linguistic errors); LUSC cis rs721399 0.539 rs10088333 chr8:18267878 G/A cg18736775 chr8:18248649 NAT2 -0.58 -6.82 -0.35 4.22e-11 Blood metabolite levels; LUSC cis rs698813 0.604 rs4953077 chr2:44481207 C/T cg00619915 chr2:44497795 NA -0.54 -7.63 -0.39 2.41e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 10.15 0.49 2.77e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2115536 1.000 rs2115540 chr15:80190308 A/G cg00225070 chr15:80189496 MTHFS 0.62 9.63 0.47 1.56e-19 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.42 -0.38 9.82e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs72634258 0.945 rs12735338 chr1:8078569 T/C cg00042356 chr1:8021962 PARK7 0.77 9.68 0.47 1.1e-19 Inflammatory bowel disease; LUSC trans rs617791 0.530 rs735942 chr11:65749337 A/G cg17712092 chr4:129076599 LARP1B -0.72 -10.11 -0.48 3.92e-21 Breast cancer; LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg01879757 chr17:41196368 BRCA1 -0.39 -5.84 -0.3 1.22e-8 Menopause (age at onset); LUSC cis rs5758659 0.652 rs133326 chr22:42406885 G/A cg04733989 chr22:42467013 NAGA 0.39 6.5 0.33 3e-10 Cognitive function; LUSC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg22532475 chr10:104410764 TRIM8 -0.31 -6.96 -0.36 1.81e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs250677 1.000 rs36082 chr5:148428844 C/G cg18129178 chr5:148520854 ABLIM3 -0.75 -11.22 -0.52 5.15e-25 Breast cancer; LUSC cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg18681998 chr4:17616180 MED28 -0.88 -15.35 -0.64 1.25e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg21535247 chr6:8435926 SLC35B3 0.6 9.14 0.45 6.03e-18 Motion sickness; LUSC cis rs4654899 1.000 rs6700718 chr1:21299363 A/C cg01072550 chr1:21505969 NA 0.51 7.8 0.39 7.73e-14 Superior frontal gyrus grey matter volume; LUSC cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg27129171 chr3:47204927 SETD2 0.73 12.78 0.57 9.89e-31 Colorectal cancer; LUSC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg12826209 chr6:26865740 GUSBL1 0.75 9.06 0.44 1.16e-17 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs11190607 chr10:102303614 C/T cg23241863 chr10:102295624 HIF1AN 0.48 5.72 0.3 2.38e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9549367 0.713 rs9549357 chr13:113860121 C/T cg18105134 chr13:113819100 PROZ -0.66 -9.29 -0.45 2.06e-18 Platelet distribution width; LUSC cis rs7769051 0.521 rs9321367 chr6:133084359 G/T cg22852734 chr6:133119734 C6orf192 1.07 9.14 0.45 6.38e-18 Type 2 diabetes nephropathy; LUSC trans rs9329221 0.648 rs4512422 chr8:10258889 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.14 -0.36 5.95e-12 Neuroticism; LUSC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg19077165 chr18:44547161 KATNAL2 0.45 6.67 0.34 1.04e-10 Personality dimensions; LUSC cis rs6062509 0.929 rs55791529 chr20:62363858 C/T cg01176363 chr20:62369445 LIME1 -0.46 -6.96 -0.36 1.84e-11 Prostate cancer; LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.19 -0.32 1.8e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.71e-9 Body mass index; LUSC trans rs7819412 0.521 rs11777887 chr8:11036799 C/G cg06636001 chr8:8085503 FLJ10661 0.5 7.31 0.37 2.03e-12 Triglycerides; LUSC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.22e-30 Aortic root size; LUSC cis rs7824557 0.767 rs17797443 chr8:11164012 T/C cg21775007 chr8:11205619 TDH 0.71 11.41 0.53 1.14e-25 Retinal vascular caliber; LUSC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs926938 0.618 rs360587 chr1:115467553 A/G cg12756093 chr1:115239321 AMPD1 0.48 7.38 0.37 1.27e-12 Autism; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.64 0.54 1.62e-26 Prudent dietary pattern; LUSC cis rs921968 0.678 rs660432 chr2:219432127 C/T cg02176678 chr2:219576539 TTLL4 0.61 11.04 0.52 2.37e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs6542838 0.609 rs12712043 chr2:99541494 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -5.84 -0.3 1.22e-8 Fear of minor pain; LUSC cis rs7904368 0.754 rs12269366 chr10:16850344 G/A cg23933602 chr10:16859644 RSU1 0.58 6.81 0.35 4.63e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs12956009 0.518 rs4458096 chr18:44819555 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.44 -6.67 -0.34 1.05e-10 Educational attainment (years of education); LUSC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 6.35 0.33 7.02e-10 Personality dimensions; LUSC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.34 0.37 1.59e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11711311 1.000 rs9811746 chr3:113515060 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.64 0.34 1.3e-10 IgG glycosylation; LUSC cis rs500891 0.533 rs9444075 chr6:84171930 A/G cg08257003 chr6:84140564 ME1 0.36 8.65 0.43 2.27e-16 Platelet-derived growth factor BB levels; LUSC cis rs12900413 0.687 rs34484228 chr15:90304067 A/G cg24249390 chr15:90295951 MESP1 -0.36 -5.69 -0.3 2.82e-8 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg15704280 chr7:45808275 SEPT13 1.02 17.62 0.69 1.3e-49 Coronary artery disease; LUSC cis rs4073582 0.516 rs1151539 chr11:66031660 C/T cg14036092 chr11:66035641 RAB1B 0.45 6.51 0.34 2.75e-10 Gout; LUSC cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg17948913 chr5:572064 NA 0.38 6.44 0.33 4.26e-10 Obesity-related traits; LUSC cis rs17401966 0.540 rs4846216 chr1:10447792 A/T cg17425144 chr1:10567563 PEX14 0.36 6.38 0.33 5.84e-10 Hepatocellular carcinoma; LUSC cis rs7123876 0.587 rs55765314 chr11:72360935 C/A cg03713592 chr11:72463424 ARAP1 0.69 7.18 0.37 4.5e-12 Body mass index; LUSC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg27398817 chr8:82754497 SNX16 -0.47 -6.36 -0.33 6.61e-10 Diastolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02466933 chr2:9770529 YWHAQ -0.49 -6.47 -0.33 3.51e-10 Bipolar disorder and schizophrenia; LUSC cis rs6906287 0.647 rs4027880 chr6:118734134 A/T cg21191810 chr6:118973309 C6orf204 0.34 6.15 0.32 2.19e-9 Electrocardiographic conduction measures; LUSC cis rs12940923 0.810 rs16942910 chr17:56363513 C/T cg19466818 chr17:56409534 MIR142 -0.38 -6.89 -0.35 2.81e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs193541 0.632 rs34486978 chr5:122312543 G/A cg19077854 chr5:122220652 SNX24 -0.4 -8.54 -0.42 4.78e-16 Glucose homeostasis traits; LUSC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg02487422 chr3:49467188 NICN1 0.45 7.13 0.36 6.24e-12 Resting heart rate; LUSC cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg03146154 chr1:46216737 IPP -0.52 -7.39 -0.37 1.21e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs727505 1.000 rs10230610 chr7:124425398 A/C cg23710748 chr7:124431027 NA -0.44 -7.92 -0.4 3.66e-14 Lewy body disease; LUSC cis rs6693567 0.565 rs10157197 chr1:150250636 G/A cg15654264 chr1:150340011 RPRD2 -0.44 -6.79 -0.35 5.13e-11 Migraine; LUSC trans rs11098499 0.863 rs6858777 chr4:120475966 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs9549367 0.789 rs9549701 chr13:113881752 G/C cg00898013 chr13:113819073 PROZ -0.57 -8.06 -0.4 1.38e-14 Platelet distribution width; LUSC cis rs57590327 0.503 rs6776737 chr3:81513729 T/C cg07356753 chr3:81810745 GBE1 0.46 6.1 0.32 3.01e-9 Extraversion; LUSC cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 11.49 0.53 5.78e-26 Colorectal cancer; LUSC cis rs10992471 0.603 rs1121978 chr9:95140351 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.08 -0.4 1.17e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9311676 0.656 rs12496906 chr3:58390490 A/C cg13750441 chr3:58318267 PXK 0.35 6.75 0.35 6.64e-11 Systemic lupus erythematosus; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg21280719 chr6:42927975 GNMT -0.32 -7.91 -0.4 3.69e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1107366 0.513 rs10934761 chr3:125973585 G/T cg01346077 chr3:125931526 NA 0.37 6.5 0.33 3e-10 Metabolite levels; LUSC cis rs11992186 0.570 rs17628941 chr8:8587534 G/C cg15556689 chr8:8085844 FLJ10661 -0.44 -6.11 -0.32 2.7e-9 Neuroticism; LUSC cis rs7829975 0.572 rs28730413 chr8:8795447 A/C cg08975724 chr8:8085496 FLJ10661 -0.42 -6.52 -0.34 2.65e-10 Mood instability; LUSC cis rs10419226 0.555 rs12976113 chr19:18767480 A/G cg22001208 chr19:18782374 NA -0.38 -6.36 -0.33 6.5e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs4969178 0.930 rs7208596 chr17:76396528 C/G cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg22907277 chr7:1156413 C7orf50 0.64 9.98 0.48 1.05e-20 Longevity;Endometriosis; LUSC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 2.83e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs68170813 0.652 rs76924513 chr7:107205887 T/C cg02696742 chr7:106810147 HBP1 -0.65 -8.53 -0.42 5.3e-16 Coronary artery disease; LUSC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg27398817 chr8:82754497 SNX16 0.66 8.41 0.42 1.18e-15 Diastolic blood pressure; LUSC cis rs6121246 0.559 rs6119728 chr20:30413121 G/A cg18721089 chr20:30220636 NA -0.31 -5.67 -0.3 3.02e-8 Mean corpuscular hemoglobin; LUSC cis rs11785400 0.762 rs7007349 chr8:143722673 T/C cg10596483 chr8:143751796 JRK 0.52 7.62 0.38 2.61e-13 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13520315 chr14:24740853 RABGGTA -0.4 -6.04 -0.31 4.05e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4622329 0.595 rs7978722 chr12:102288952 G/T cg23541617 chr12:102225335 GNPTAB 0.27 6.21 0.32 1.55e-9 Systemic lupus erythematosus; LUSC cis rs244293 0.931 rs244306 chr17:53237683 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.93 -0.31 7.63e-9 Menarche (age at onset); LUSC cis rs11098499 0.739 rs9884728 chr4:120127079 C/T cg09307838 chr4:120376055 NA -0.6 -8.77 -0.43 8.98e-17 Corneal astigmatism; LUSC cis rs72960926 0.744 rs72959615 chr6:74991323 C/T cg03266952 chr6:74778945 NA -0.8 -6.78 -0.35 5.51e-11 Metabolite levels (MHPG); LUSC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg19920283 chr7:105172520 RINT1 0.59 6.15 0.32 2.24e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg17764715 chr19:33622953 WDR88 0.53 7.91 0.4 3.9e-14 Colorectal cancer; LUSC cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg13010199 chr12:38710504 ALG10B 0.69 11.38 0.53 1.39e-25 Heart rate; LUSC cis rs4839421 0.646 rs11102123 chr1:111016796 A/G cg06880108 chr1:111021908 CYMP 0.35 5.83 0.3 1.32e-8 Response to bupropion in depression; LUSC cis rs9650315 0.733 rs13260127 chr8:57202941 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.34 0.37 1.64e-12 Height; LUSC trans rs9784649 0.760 rs17403440 chr5:25054004 C/T cg08600765 chr20:34638493 LOC647979 -0.53 -6.78 -0.35 5.56e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC trans rs12080794 1.000 rs12736630 chr1:9153885 A/T cg11315153 chr6:62996299 KHDRBS2 -0.51 -6.1 -0.32 2.88e-9 Response to antidepressant treatment (citalopram); LUSC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -5.98 -0.31 5.71e-9 Personality dimensions; LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg04944784 chr2:26401820 FAM59B -0.74 -10.67 -0.5 4.46e-23 Gut microbiome composition (summer); LUSC cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Bladder cancer; LUSC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg00049323 chr5:472564 LOC25845 -0.44 -6.94 -0.35 2.05e-11 Cystic fibrosis severity; LUSC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg04455712 chr21:45112962 RRP1B 0.5 9.42 0.46 7.53e-19 Mean corpuscular volume; LUSC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg17554472 chr22:41940697 POLR3H -0.48 -5.87 -0.31 1.05e-8 Vitiligo; LUSC cis rs1691799 0.831 rs6581678 chr12:66776656 A/G cg16791601 chr12:66731901 HELB -0.71 -12.08 -0.55 3.93e-28 White blood cell count (basophil); LUSC trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg11887960 chr12:57824829 NA 0.57 7.01 0.36 1.3e-11 Lung disease severity in cystic fibrosis; LUSC trans rs6598955 0.671 rs12129482 chr1:26623641 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.66 -9.0 -0.44 1.77e-17 Obesity-related traits; LUSC cis rs17818399 0.926 rs7590693 chr2:46823992 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.47 -6.29 -0.33 9.92e-10 Height; LUSC trans rs9650657 0.585 rs4841401 chr8:10489592 C/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.45 -0.33 3.96e-10 Neuroticism; LUSC cis rs6120849 0.754 rs6120819 chr20:33653038 T/C cg24642439 chr20:33292090 TP53INP2 0.59 6.53 0.34 2.5e-10 Protein C levels; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg07677032 chr17:61819896 STRADA 0.52 8.61 0.43 2.91e-16 Prudent dietary pattern; LUSC cis rs10950821 0.505 rs6949755 chr7:20688042 C/G cg02470904 chr7:20686108 ABCB5 0.34 6.39 0.33 5.65e-10 Response to statin therapy; LUSC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.69 0.5 3.96e-23 Schizophrenia; LUSC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg24829409 chr8:58192753 C8orf71 -0.65 -6.49 -0.33 3.07e-10 Developmental language disorder (linguistic errors); LUSC trans rs8022206 1.000 rs72725138 chr14:68387979 C/T cg15809352 chr2:121748218 GLI2 0.44 6.25 0.32 1.28e-9 Platelet count;Mean platelet volume; LUSC cis rs12908161 1.000 rs34900908 chr15:85257599 G/A cg11189052 chr15:85197271 WDR73 0.49 5.98 0.31 5.78e-9 Schizophrenia; LUSC trans rs724744 0.742 rs714589 chr6:22359969 A/G cg13807341 chr11:118445984 ARCN1 -0.35 -5.97 -0.31 6.14e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs12410462 0.681 rs113984727 chr1:227553917 C/A cg04117972 chr1:227635322 NA 0.58 6.44 0.33 4.21e-10 Major depressive disorder; LUSC cis rs7224314 1.000 rs62084081 chr17:65387148 G/C cg01507342 chr17:65387096 PITPNC1 -0.44 -7.81 -0.39 7.54e-14 Diisocyanate-induced asthma; LUSC cis rs9309473 1.000 rs7598396 chr2:73652628 A/G cg20560298 chr2:73613845 ALMS1 -0.44 -6.4 -0.33 5.36e-10 Metabolite levels; LUSC cis rs870825 0.655 rs35764203 chr4:185639078 C/A cg04058563 chr4:185651563 MLF1IP 0.87 13.55 0.6 1.23e-33 Blood protein levels; LUSC cis rs4604732 0.536 rs12049066 chr1:247642655 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.38 5.67 0.3 3.07e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs861020 0.771 rs629150 chr1:209998467 C/T cg05527609 chr1:210001259 C1orf107 1.0 14.18 0.61 4.66e-36 Orofacial clefts; LUSC cis rs9865818 0.754 rs11706429 chr3:188099242 G/A cg23651889 chr3:188115336 LPP 0.39 5.82 0.3 1.4e-8 Allergic sensitization; LUSC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg14456004 chr13:21872349 NA 0.46 6.52 0.34 2.64e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg18477163 chr1:228402036 OBSCN -0.55 -10.34 -0.49 6.38e-22 Diastolic blood pressure; LUSC cis rs13223928 0.605 rs10951052 chr7:3155301 A/G cg19214707 chr7:3157722 NA -0.53 -10.38 -0.49 4.73e-22 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg23093090 chr10:104574429 C10orf26 -0.39 -7.25 -0.37 2.91e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1577917 0.687 rs1470531 chr6:86507369 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.74 -0.35 6.87e-11 Response to antipsychotic treatment; LUSC cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg22437258 chr11:111473054 SIK2 -0.48 -6.23 -0.32 1.41e-9 Primary sclerosing cholangitis; LUSC cis rs11997175 0.624 rs6996590 chr8:33680486 A/G ch.8.33884649F chr8:33765107 NA 0.47 7.05 0.36 1.01e-11 Body mass index; LUSC cis rs7833986 0.501 rs72653917 chr8:56892844 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.69 11.13 0.52 1.12e-24 Height; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs13082711 0.555 rs73149363 chr3:27265394 C/A cg02860705 chr3:27208620 NA 0.66 11.31 0.53 2.6e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs950169 0.887 rs3860265 chr15:84945185 C/T cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg20887711 chr4:1340912 KIAA1530 0.47 7.15 0.36 5.57e-12 Obesity-related traits; LUSC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg01579765 chr21:45077557 HSF2BP -0.55 -11.56 -0.53 3.06e-26 Mean corpuscular volume; LUSC cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg21280719 chr6:42927975 GNMT -0.3 -7.53 -0.38 4.9e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2425143 1.000 rs2378409 chr20:34392464 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -5.87 -0.31 1.03e-8 Blood protein levels; LUSC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.05e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg18252515 chr7:66147081 NA -1.18 -13.0 -0.58 1.52e-31 Diabetic kidney disease; LUSC cis rs698813 0.674 rs6544751 chr2:44495845 A/G cg00619915 chr2:44497795 NA -0.51 -6.95 -0.36 1.95e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs12310956 0.532 rs1352211 chr12:33983132 G/A cg13010199 chr12:38710504 ALG10B 0.52 7.72 0.39 1.34e-13 Morning vs. evening chronotype; LUSC trans rs11098499 0.954 rs7437420 chr4:120312903 A/G cg25214090 chr10:38739885 LOC399744 0.54 7.94 0.4 3.01e-14 Corneal astigmatism; LUSC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg18404041 chr3:52824283 ITIH1 -0.58 -9.89 -0.48 2.17e-20 Schizophrenia; LUSC cis rs9479482 1.000 rs9479403 chr6:150337746 C/T cg07578070 chr6:150326732 RAET1K -0.36 -5.68 -0.3 2.86e-8 Alopecia areata; LUSC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg06636001 chr8:8085503 FLJ10661 0.64 10.22 0.49 1.59e-21 Mood instability; LUSC cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg11266682 chr4:10021025 SLC2A9 0.43 7.6 0.38 2.94e-13 Bone mineral density; LUSC cis rs17253792 0.822 rs17746033 chr14:56061837 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs10992471 0.756 rs10992319 chr9:95127895 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.23 -0.41 4.27e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7208859 0.623 rs1061346 chr17:29114229 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.42 0.42 1.16e-15 Tonsillectomy; LUSC cis rs17604090 0.646 rs10258473 chr7:29690439 A/C cg19413766 chr7:29689036 LOC646762 -0.6 -7.26 -0.37 2.77e-12 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.15 0.36 5.38e-12 Rheumatoid arthritis; LUSC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs9646944 0.501 rs3771161 chr2:103003961 C/A cg20060108 chr2:102954350 IL1RL1 0.48 6.38 0.33 5.79e-10 Blood protein levels; LUSC cis rs2236918 1.000 rs2797605 chr1:242025245 A/T cg17736920 chr1:242011382 EXO1 0.44 6.94 0.36 2e-11 Menopause (age at onset); LUSC cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.21 28.93 0.85 5.33e-93 Chronic sinus infection; LUSC cis rs2898681 0.642 rs62336790 chr4:53728000 T/C cg00338735 chr4:53728038 RASL11B 0.41 5.71 0.3 2.49e-8 Optic nerve measurement (cup area); LUSC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg12257692 chr3:49977190 RBM6 0.24 6.67 0.34 1.06e-10 Intelligence (multi-trait analysis); LUSC cis rs6696846 0.936 rs1042831 chr1:205043250 G/C cg03948781 chr1:205179583 DSTYK 0.31 5.79 0.3 1.63e-8 Red blood cell count; LUSC cis rs17253792 0.822 rs77676035 chr14:56096229 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.4 0.38 1.14e-12 Motion sickness; LUSC trans rs72674100 0.867 rs10017627 chr4:97983818 T/G cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs826838 0.804 rs6580755 chr12:39159190 C/T cg26384229 chr12:38710491 ALG10B 0.92 17.62 0.69 1.4e-49 Heart rate; LUSC cis rs4953404 0.613 rs1531132 chr2:46892315 A/G cg09399716 chr2:46890238 NA -0.32 -7.25 -0.37 2.88e-12 Pulse pressure (alcohol consumption interaction); LUSC cis rs62400317 0.701 rs12194924 chr6:44961513 T/C cg18551225 chr6:44695536 NA -0.44 -7.03 -0.36 1.19e-11 Total body bone mineral density; LUSC cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg15556689 chr8:8085844 FLJ10661 0.59 9.16 0.45 5.29e-18 Mood instability; LUSC cis rs9287719 0.967 rs2024431 chr2:10731327 A/G cg00105475 chr2:10696890 NA 0.37 6.09 0.32 3.03e-9 Prostate cancer; LUSC cis rs7727544 0.545 rs3916443 chr5:131369079 T/C cg14196790 chr5:131705035 SLC22A5 0.41 6.49 0.33 3.17e-10 Blood metabolite levels; LUSC cis rs7246657 0.943 rs10422967 chr19:37850137 T/C cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC trans rs1223397 0.702 rs13191897 chr6:13288428 G/A cg13974761 chr1:152670598 LCE2A 0.37 5.96 0.31 6.56e-9 Blood pressure; LUSC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC cis rs12681288 0.676 rs2600514 chr8:994175 G/A cg04851639 chr8:1020857 NA -0.39 -8.18 -0.41 6.06e-15 Schizophrenia; LUSC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Melanoma; LUSC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg21951975 chr1:209979733 IRF6 0.63 8.04 0.4 1.53e-14 Cleft lip with or without cleft palate; LUSC cis rs9486719 0.895 rs12190520 chr6:96928620 A/C cg06623918 chr6:96969491 KIAA0776 -0.82 -10.0 -0.48 9.04e-21 Migraine;Coronary artery disease; LUSC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11890956 chr21:40555474 PSMG1 -0.74 -11.11 -0.52 1.3e-24 Menarche (age at onset); LUSC cis rs9868809 0.656 rs73078362 chr3:48703917 G/C cg00383909 chr3:49044727 WDR6 1.39 10.54 0.5 1.35e-22 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7568458 0.846 rs7605975 chr2:85772548 C/T cg02493740 chr2:85810744 VAMP5 -0.36 -6.43 -0.33 4.46e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg23758822 chr17:41437982 NA 1.04 19.81 0.74 2.6e-58 Menopause (age at onset); LUSC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg11752832 chr7:134001865 SLC35B4 0.6 9.32 0.45 1.62e-18 Mean platelet volume; LUSC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.91 -0.35 2.41e-11 Coronary artery disease; LUSC cis rs11098499 0.863 rs6853998 chr4:120475860 C/A cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg08773314 chr2:239334832 ASB1 0.39 8.34 0.42 2.02e-15 Multiple system atrophy; LUSC cis rs12220238 1.000 rs11000897 chr10:75911276 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.89 0.35 2.82e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2116941 1.000 rs2033493 chr19:10340854 A/C cg01850179 chr19:10340795 S1PR2 -0.71 -12.48 -0.56 1.29e-29 Pulse pressure; LUSC cis rs2898681 0.580 rs41279517 chr4:53729771 T/C cg00791764 chr4:53727839 RASL11B 0.57 7.24 0.37 3.1e-12 Optic nerve measurement (cup area); LUSC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg06808227 chr14:105710500 BRF1 -0.65 -10.01 -0.48 8.32e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs9457247 0.566 rs10946207 chr6:167456036 C/T cg06454157 chr6:167490870 NA -0.29 -6.61 -0.34 1.5e-10 Crohn's disease; LUSC cis rs4499344 0.921 rs4805776 chr19:33087759 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.61 -7.83 -0.39 6.39e-14 Mean platelet volume; LUSC cis rs7246967 0.611 rs1835993 chr19:22833037 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs3857536 0.813 rs9360189 chr6:66933424 A/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.79 0.7 2.73e-50 Chronic sinus infection; LUSC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg23985595 chr17:80112537 CCDC57 -0.3 -5.75 -0.3 2.05e-8 Life satisfaction; LUSC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg09323728 chr8:95962352 TP53INP1 -0.45 -9.45 -0.46 5.92e-19 Type 2 diabetes; LUSC cis rs68170813 0.559 rs2395881 chr7:107074323 A/C cg24556660 chr7:106842632 COG5;HBP1 -0.44 -5.71 -0.3 2.54e-8 Coronary artery disease; LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs7937682 0.632 rs2070894 chr11:111780837 G/A cg18187862 chr3:45730750 SACM1L -0.53 -6.51 -0.34 2.69e-10 Primary sclerosing cholangitis; LUSC cis rs3806843 0.547 rs246048 chr5:140327900 G/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs77972916 0.611 rs6709988 chr2:43601317 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.44 -5.75 -0.3 2.02e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs208520 0.690 rs176289 chr6:66766522 C/T cg07460842 chr6:66804631 NA -1.11 -17.44 -0.69 6.67e-49 Exhaled nitric oxide output; LUSC cis rs10789491 1.000 rs12794 chr1:47141718 T/C cg15501359 chr1:47185051 KIAA0494 0.8 11.38 0.53 1.41e-25 Response to hepatitis C treatment; LUSC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.75 11.01 0.52 3.04e-24 Cognitive test performance; LUSC cis rs4808199 0.649 rs17216693 chr19:19666574 T/C cg03709012 chr19:19516395 GATAD2A 0.92 10.27 0.49 1.13e-21 Nonalcoholic fatty liver disease; LUSC cis rs10489525 0.583 rs6660550 chr1:115650850 C/G cg01522456 chr1:115632236 TSPAN2 0.68 10.06 0.48 5.9e-21 Autism; LUSC cis rs11264213 0.901 rs74879824 chr1:36413117 T/A cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.39e-14 Schizophrenia; LUSC cis rs2429369 0.528 rs2526376 chr17:56427142 A/C cg12560992 chr17:57184187 TRIM37 0.45 6.98 0.36 1.61e-11 Cognitive function; LUSC cis rs2806561 0.765 rs2806556 chr1:23502850 G/A cg12483005 chr1:23474871 LUZP1 0.4 5.99 0.31 5.32e-9 Height; LUSC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs3761218 1.000 rs3761218 chr20:3776175 A/G cg02737268 chr20:3780182 CDC25B -0.32 -6.31 -0.33 8.91e-10 Bipolar disorder; LUSC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg24829409 chr8:58192753 C8orf71 -0.65 -6.51 -0.34 2.84e-10 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.534 rs4547187 chr12:34041259 T/C cg26384229 chr12:38710491 ALG10B 0.67 10.61 0.5 7.65e-23 Morning vs. evening chronotype; LUSC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg16235748 chr6:149772707 ZC3H12D -0.32 -6.47 -0.33 3.42e-10 Dupuytren's disease; LUSC cis rs909002 0.800 rs3134718 chr1:32089839 C/T cg01639898 chr1:32083012 HCRTR1 0.31 7.59 0.38 3.32e-13 Intelligence (multi-trait analysis); LUSC cis rs4862307 0.720 rs12650935 chr4:184989565 G/A cg06737308 chr4:185021514 ENPP6 0.47 6.98 0.36 1.6e-11 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs7312933 0.558 rs1796384 chr12:42780568 G/A cg01256987 chr12:42539512 GXYLT1 0.36 6.49 0.33 3.14e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6554196 0.644 rs7655709 chr4:55499386 C/G cg18836493 chr4:55524333 KIT -0.34 -5.67 -0.3 3.06e-8 Monocyte count; LUSC cis rs8060686 0.516 rs255052 chr16:68024995 C/T cg09835421 chr16:68378352 PRMT7 -0.56 -6.56 -0.34 2.05e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg00800038 chr16:89945340 TCF25 -0.75 -6.64 -0.34 1.26e-10 Skin colour saturation; LUSC cis rs10492096 1.000 rs11064210 chr12:6576721 C/T cg13857086 chr12:6580257 VAMP1 0.72 8.23 0.41 4.15e-15 Hip geometry; LUSC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg15556689 chr8:8085844 FLJ10661 -0.66 -10.27 -0.49 1.06e-21 Mood instability; LUSC cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg04455712 chr21:45112962 RRP1B 0.45 8.37 0.42 1.62e-15 Mean corpuscular volume; LUSC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg21963583 chr11:68658836 MRPL21 0.51 7.8 0.39 8.13e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs68170813 0.559 rs78888729 chr7:106940957 G/C cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.65 -0.3 3.5e-8 Coronary artery disease; LUSC cis rs2153535 0.967 rs10484750 chr6:8378609 A/G cg21535247 chr6:8435926 SLC35B3 -0.47 -7.01 -0.36 1.29e-11 Motion sickness; LUSC cis rs7903847 0.620 rs61863813 chr10:99112786 T/C cg08345082 chr10:99160200 RRP12 -0.36 -7.01 -0.36 1.35e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg05872129 chr22:39784769 NA 0.51 8.44 0.42 9.44e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6542838 0.611 rs6742047 chr2:99531460 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.51 -0.38 5.39e-13 Fear of minor pain; LUSC cis rs6714710 0.603 rs1875699 chr2:98580724 G/T cg26665480 chr2:98280029 ACTR1B 0.58 8.43 0.42 1.04e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7786877 0.626 rs11770389 chr7:100221218 T/G cg00334542 chr7:100209784 MOSPD3 -0.67 -7.51 -0.38 5.61e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs354225 0.544 rs7599241 chr2:54801856 G/A cg01766943 chr2:54829624 SPTBN1 0.47 7.56 0.38 3.95e-13 Schizophrenia; LUSC cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg03146154 chr1:46216737 IPP 0.56 8.32 0.41 2.35e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs41271473 1.000 rs1062060 chr1:228880021 A/G cg10167378 chr1:228756711 NA -0.49 -5.9 -0.31 9.06e-9 Chronic lymphocytic leukemia; LUSC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs11168618 0.776 rs7955785 chr12:48862538 T/A cg24011408 chr12:48396354 COL2A1 0.38 5.94 0.31 7.32e-9 Adiponectin levels; LUSC cis rs1997103 0.954 rs2177807 chr7:55391002 G/T cg17469321 chr7:55412551 NA -0.64 -11.03 -0.52 2.52e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs41271473 0.526 rs10916343 chr1:228727961 C/T cg10167378 chr1:228756711 NA 0.76 9.78 0.47 5.16e-20 Chronic lymphocytic leukemia; LUSC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg05425664 chr17:57184151 TRIM37 0.62 9.62 0.47 1.75e-19 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.666 rs60671275 chr2:238374318 C/A cg16989719 chr2:238392110 NA -0.47 -7.56 -0.38 4.01e-13 Prostate cancer; LUSC cis rs30380 0.632 rs26491 chr5:96134113 A/G cg16492584 chr5:96139282 ERAP1 -0.56 -7.56 -0.38 3.94e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg20887711 chr4:1340912 KIAA1530 -0.45 -7.1 -0.36 7.58e-12 Obesity-related traits; LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg11645453 chr3:52864694 ITIH4 0.35 8.0 0.4 2.1e-14 Bipolar disorder; LUSC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg15556689 chr8:8085844 FLJ10661 0.58 9.09 0.45 8.82e-18 Neuroticism; LUSC cis rs1712517 0.873 rs1712516 chr10:105033628 G/A cg05636881 chr10:105038444 INA 0.4 6.67 0.34 1.06e-10 Migraine; LUSC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg22535103 chr8:58192502 C8orf71 -0.74 -9.37 -0.46 1.15e-18 Developmental language disorder (linguistic errors); LUSC cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs722599 0.599 rs3825708 chr14:75200697 C/T cg08847533 chr14:75593920 NEK9 0.42 6.06 0.31 3.61e-9 IgG glycosylation; LUSC cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg13010199 chr12:38710504 ALG10B 0.66 10.18 0.49 2.16e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs1577917 1.000 rs791856 chr6:86681841 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.29 0.41 2.85e-15 Response to antipsychotic treatment; LUSC cis rs4718428 1.000 rs4718428 chr7:66421446 T/G cg18252515 chr7:66147081 NA -0.39 -6.0 -0.31 5e-9 Corneal structure; LUSC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg26513180 chr16:89883248 FANCA -0.54 -8.06 -0.4 1.39e-14 Vitiligo; LUSC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -6.9 -0.35 2.59e-11 Alzheimer's disease (late onset); LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02018176 chr4:1364513 KIAA1530 -0.73 -13.42 -0.59 3.88e-33 Longevity; LUSC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg12310025 chr6:25882481 NA -0.58 -9.6 -0.47 1.92e-19 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.78 -0.35 5.54e-11 Monocyte percentage of white cells; LUSC cis rs9311676 0.632 rs62258139 chr3:58406836 C/T cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.1e-10 Systemic lupus erythematosus; LUSC cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.04 0.31 4.19e-9 Schizophrenia; LUSC cis rs59104589 0.617 rs3771550 chr2:242302811 A/G cg14842376 chr2:242211374 HDLBP 0.53 5.99 0.31 5.3e-9 Fibrinogen levels; LUSC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg17264618 chr3:40429014 ENTPD3 0.35 7.08 0.36 8.58e-12 Renal cell carcinoma; LUSC trans rs10221833 0.530 rs355888 chr2:165634551 A/G cg26993132 chr16:89239499 CDH15 0.31 5.99 0.31 5.47e-9 Response to statin therapy; LUSC trans rs61931739 0.679 rs10844831 chr12:34311245 G/T cg13010199 chr12:38710504 ALG10B 0.41 6.37 0.33 6.44e-10 Morning vs. evening chronotype; LUSC cis rs1882538 0.564 rs12707090 chr7:133115163 G/A cg10665199 chr7:133106180 EXOC4 0.57 8.04 0.4 1.57e-14 Intelligence (multi-trait analysis); LUSC cis rs6961069 0.713 rs3211821 chr7:80278563 A/G cg04458919 chr7:80252533 CD36 0.34 6.16 0.32 2.09e-9 Platelet count; LUSC cis rs11122272 0.735 rs2250719 chr1:231486208 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.87 -0.48 2.48e-20 Hemoglobin concentration; LUSC cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg12573674 chr2:1569213 NA -0.52 -5.67 -0.3 3.07e-8 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs722599 0.748 rs61978932 chr14:75342954 C/T cg06637938 chr14:75390232 RPS6KL1 -0.41 -6.07 -0.32 3.46e-9 IgG glycosylation; LUSC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg00409905 chr10:38381863 ZNF37A 0.4 6.89 0.35 2.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg16049864 chr8:95962084 TP53INP1 -0.42 -7.14 -0.36 5.8e-12 Type 2 diabetes; LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg06258179 chr7:92463261 CDK6 0.39 5.99 0.31 5.31e-9 Bladder cancer; LUSC cis rs6012953 0.560 rs4811079 chr20:49157052 G/C cg13958625 chr20:49123093 NA -0.27 -5.69 -0.3 2.82e-8 Vitiligo; LUSC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg17971929 chr21:40555470 PSMG1 0.8 14.09 0.61 1.04e-35 Cognitive function; LUSC cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg10802521 chr3:52805072 NEK4 -0.42 -6.57 -0.34 1.9e-10 Electroencephalogram traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05662500 chr3:32147877 GPD1L 0.39 6.09 0.32 3.17e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6598955 0.543 rs17163720 chr1:26549399 A/G cg12744634 chr1:26560303 CCDC21 -0.39 -5.78 -0.3 1.74e-8 Obesity-related traits; LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg22166914 chr1:53195759 ZYG11B -0.62 -10.21 -0.49 1.73e-21 Monocyte count; LUSC trans rs890100 0.803 rs4672120 chr2:56722404 A/G cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.31 -5.99 -0.31 5.38e-9 Gut microbiome composition (summer); LUSC cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg13010199 chr12:38710504 ALG10B -0.58 -9.17 -0.45 4.95e-18 Bladder cancer; LUSC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg01879757 chr17:41196368 BRCA1 0.51 8.36 0.42 1.69e-15 Menopause (age at onset); LUSC trans rs17685 0.753 rs4728586 chr7:75802869 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 18.86 0.72 1.61e-54 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2760061 0.583 rs708123 chr1:228220495 A/G cg18477163 chr1:228402036 OBSCN 0.54 9.12 0.45 7.43e-18 Diastolic blood pressure; LUSC cis rs2224391 0.628 rs2773316 chr6:5254448 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.39 -0.33 5.73e-10 Height; LUSC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.5 0.34 2.94e-10 Lung cancer; LUSC cis rs929354 0.742 rs7785227 chr7:156999297 C/T cg17757837 chr7:157058334 UBE3C 0.83 13.32 0.59 9.03e-33 Body mass index; LUSC cis rs4499344 0.693 rs382416 chr19:33107938 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.81 -11.64 -0.54 1.66e-26 Mean platelet volume; LUSC cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg15395560 chr15:45543142 SLC28A2 0.33 5.66 0.3 3.25e-8 Uric acid levels; LUSC cis rs7202877 0.706 rs40217 chr16:75480066 C/A cg04384234 chr16:75411784 CFDP1 0.67 8.85 0.44 5.04e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs3806843 1.000 rs7710794 chr5:140209467 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.77 -0.3 1.79e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs3008870 1.000 rs2815352 chr1:67482104 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.31 0.64 1.87e-40 Lymphocyte percentage of white cells; LUSC cis rs4295623 0.559 rs4841600 chr8:11688148 T/C cg21775007 chr8:11205619 TDH 0.45 6.26 0.32 1.16e-9 Morning vs. evening chronotype; LUSC cis rs6987853 0.787 rs2974354 chr8:42413943 A/G cg09913449 chr8:42400586 C8orf40 0.5 8.49 0.42 7.07e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs7215564 0.908 rs7501674 chr17:78662177 C/T cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.27e-9 Myopia (pathological); LUSC cis rs9902453 0.765 rs62068653 chr17:28212663 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.38 0.53 1.44e-25 Coffee consumption (cups per day); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg13696300 chr17:18162128 FLII -0.45 -6.79 -0.35 5.14e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg02187348 chr16:89574699 SPG7 -0.47 -7.07 -0.36 9.27e-12 Multiple myeloma (IgH translocation); LUSC trans rs2228479 0.850 rs17226519 chr16:89839854 T/C cg24644049 chr4:85504048 CDS1 0.86 7.56 0.38 3.83e-13 Skin colour saturation; LUSC trans rs62055045 0.528 rs62056195 chr16:71549485 A/G cg09088153 chr15:96890598 NA -0.48 -6.56 -0.34 2.06e-10 Schizophrenia; LUSC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.88 0.35 2.89e-11 Menarche (age at onset); LUSC cis rs116095464 0.558 rs6866632 chr5:264429 C/G cg22857025 chr5:266934 NA -1.14 -15.9 -0.66 8.73e-43 Breast cancer; LUSC cis rs427941 0.703 rs201445 chr7:101737921 G/T cg06246474 chr7:101738831 CUX1 0.41 6.71 0.34 8.45e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs2667011 0.512 rs1995950 chr2:160800628 A/G cg06573604 chr2:160760825 LY75 0.44 6.17 0.32 1.98e-9 Bilirubin levels; LUSC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg00033643 chr7:134001901 SLC35B4 0.45 7.05 0.36 1.02e-11 Mean platelet volume; LUSC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg20744362 chr22:50050164 C22orf34 0.39 7.94 0.4 3.13e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg12463550 chr7:65579703 CRCP 0.43 6.2 0.32 1.71e-9 Aortic root size; LUSC trans rs7155454 0.935 rs11627531 chr14:65487796 T/C cg18497238 chr14:75083495 NA -0.25 -5.94 -0.31 6.97e-9 Mean corpuscular volume;Red blood cell traits;Mean corpuscular hemoglobin; LUSC cis rs1801251 1.000 rs6761324 chr2:233582793 T/G cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.33 2.99e-10 Coronary artery disease; LUSC cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.92 -11.76 -0.54 5.89e-27 Chronic sinus infection; LUSC cis rs7215564 0.818 rs34929663 chr17:78617212 C/T cg23238734 chr17:78661607 RPTOR 0.48 6.17 0.32 1.96e-9 Myopia (pathological); LUSC cis rs208520 0.874 rs208514 chr6:66945520 G/A cg07460842 chr6:66804631 NA -1.0 -14.23 -0.61 3.12e-36 Exhaled nitric oxide output; LUSC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.9 0.35 2.56e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg18404041 chr3:52824283 ITIH1 -0.51 -9.69 -0.47 1e-19 Bipolar disorder; LUSC cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -8.47 -0.42 8.04e-16 Personality dimensions; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -6.97 -0.36 1.75e-11 Bipolar disorder; LUSC cis rs7589342 0.628 rs35482041 chr2:106409436 A/G cg14210321 chr2:106509881 NCK2 -0.45 -5.73 -0.3 2.23e-8 Addiction; LUSC cis rs9287719 0.935 rs61424402 chr2:10758371 T/A cg00105475 chr2:10696890 NA 0.37 6.28 0.33 1.04e-9 Prostate cancer; LUSC cis rs7312933 0.618 rs12366848 chr12:42682215 A/G cg01256987 chr12:42539512 GXYLT1 -0.41 -7.56 -0.38 3.98e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg07148914 chr20:33460835 GGT7 0.55 8.4 0.42 1.33e-15 Height; LUSC cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg19628046 chr18:33552617 C18orf21 0.51 6.13 0.32 2.47e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg10018233 chr7:150070692 REPIN1 0.38 6.62 0.34 1.42e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.6 0.69 1.6e-49 Chronic sinus infection; LUSC cis rs7312933 0.558 rs11181463 chr12:42763636 C/T cg17420585 chr12:42539391 GXYLT1 -0.3 -5.75 -0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9457247 0.602 rs12209395 chr6:167463914 C/T cg06454157 chr6:167490870 NA -0.29 -6.89 -0.35 2.84e-11 Crohn's disease; LUSC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg18404041 chr3:52824283 ITIH1 -0.58 -9.62 -0.47 1.75e-19 Schizophrenia; LUSC cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg06550200 chr5:1325588 CLPTM1L -0.65 -11.16 -0.52 8.81e-25 Lung cancer; LUSC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg18230493 chr5:56204884 C5orf35 -0.88 -13.23 -0.59 2.03e-32 Initial pursuit acceleration; LUSC cis rs9457247 0.515 rs2757039 chr6:167370353 G/T cg25258033 chr6:167368657 RNASET2 -0.36 -5.79 -0.3 1.63e-8 Crohn's disease; LUSC cis rs354225 0.513 rs10187338 chr2:54806611 A/G cg01766943 chr2:54829624 SPTBN1 0.49 7.94 0.4 3.16e-14 Schizophrenia; LUSC cis rs11229555 0.874 rs11605269 chr11:58350872 A/G cg15696309 chr11:58395628 NA -0.71 -9.19 -0.45 4.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10911363 0.592 rs2702178 chr1:183452545 G/A cg09173681 chr1:183549694 NCF2 0.66 12.24 0.56 1.08e-28 Systemic lupus erythematosus; LUSC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg20203395 chr5:56204925 C5orf35 0.44 6.51 0.34 2.74e-10 Coronary artery disease; LUSC cis rs2303282 0.664 rs2440474 chr16:56432435 G/T cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.88e-12 Breast cancer; LUSC cis rs4853525 0.818 rs4853520 chr2:191719498 A/G cg11845111 chr2:191398756 TMEM194B -0.42 -6.18 -0.32 1.91e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs1950626 0.833 rs34463495 chr14:101411186 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.42 7.46 0.38 7.73e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg04450456 chr4:17643702 FAM184B 0.41 6.96 0.36 1.78e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7772697 0.508 rs6570924 chr6:149365050 C/T cg22609380 chr12:98849379 NA 0.36 6.58 0.34 1.78e-10 Diabetic retinopathy; LUSC cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg08807101 chr21:30365312 RNF160 0.8 15.16 0.64 7.39e-40 Dental caries; LUSC cis rs4746818 1.000 rs10823301 chr10:70885875 G/A cg11621586 chr10:70884670 VPS26A 1.15 14.56 0.62 1.52e-37 Left atrial antero-posterior diameter; LUSC cis rs6942756 1.000 rs2012919 chr7:128890812 C/T cg02491457 chr7:128862824 NA -0.52 -7.43 -0.38 9.06e-13 White matter hyperintensity burden; LUSC cis rs1005224 0.889 rs12717566 chr14:76147507 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.66 -8.86 -0.44 4.89e-17 Large artery stroke; LUSC cis rs7707921 0.705 rs226194 chr5:81585026 G/T cg15871215 chr5:81402204 ATG10 0.45 7.08 0.36 8.34e-12 Breast cancer; LUSC cis rs2635047 0.624 rs2289036 chr18:44595809 A/T cg19077165 chr18:44547161 KATNAL2 0.4 5.76 0.3 1.95e-8 Educational attainment; LUSC cis rs55794721 0.509 rs12027135 chr1:25775733 A/T cg23205692 chr1:25664452 TMEM50A 0.39 5.74 0.3 2.08e-8 Plateletcrit;Mean corpuscular volume; LUSC cis rs7512552 0.803 rs9436125 chr1:150487961 C/G cg15654264 chr1:150340011 RPRD2 0.61 9.84 0.47 3.16e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13732083 chr21:47605072 C21orf56 0.42 6.28 0.32 1.07e-9 Testicular germ cell tumor; LUSC cis rs7605827 0.897 rs6745917 chr2:15537924 G/C cg19274914 chr2:15703543 NA 0.46 8.95 0.44 2.44e-17 Educational attainment (years of education); LUSC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg14829155 chr15:31115871 NA -0.58 -8.1 -0.41 1.03e-14 Huntington's disease progression; LUSC cis rs477692 1.000 rs567700 chr10:131423126 C/T cg05714579 chr10:131428358 MGMT 0.5 7.43 0.38 9.36e-13 Response to temozolomide; LUSC cis rs7267979 0.714 rs6132825 chr20:25238309 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.6 11.06 0.52 1.95e-24 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10489525 0.599 rs2335724 chr1:115608444 T/C cg01522456 chr1:115632236 TSPAN2 0.49 6.98 0.36 1.56e-11 Autism; LUSC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg12365402 chr11:9010492 NRIP3 0.44 8.11 0.41 9.62e-15 Hemoglobin concentration; LUSC cis rs561341 0.609 rs11658984 chr17:30186612 C/T cg13647721 chr17:30228624 UTP6 -0.69 -7.5 -0.38 5.71e-13 Hip circumference adjusted for BMI; LUSC cis rs73416724 1.000 rs76823934 chr6:43359424 G/A cg26312998 chr6:43337775 ZNF318 0.56 6.67 0.34 1.04e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg22549504 chr19:17448937 GTPBP3 0.54 6.74 0.35 6.84e-11 Systemic lupus erythematosus; LUSC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg05868516 chr6:26286170 HIST1H4H 0.35 5.78 0.3 1.69e-8 Educational attainment; LUSC cis rs1448094 0.967 rs10863115 chr12:86332586 T/C cg02569458 chr12:86230093 RASSF9 0.42 6.79 0.35 5.11e-11 Major depressive disorder; LUSC cis rs7166081 0.672 rs12441715 chr15:67860587 G/A cg24579218 chr15:68104479 NA -0.35 -5.82 -0.3 1.38e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg09877947 chr5:131593287 PDLIM4 0.44 7.35 0.37 1.58e-12 Breast cancer; LUSC cis rs1577917 0.958 rs3900313 chr6:86537154 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg23758822 chr17:41437982 NA 1.05 19.04 0.72 3.07e-55 Menopause (age at onset); LUSC cis rs9329221 0.513 rs4841296 chr8:10105447 C/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.07 -0.32 3.47e-9 Neuroticism; LUSC cis rs6977660 1.000 rs12672557 chr7:19804237 G/A cg07541023 chr7:19748670 TWISTNB 0.56 6.28 0.33 1.05e-9 Thyroid stimulating hormone; LUSC cis rs12893668 0.703 rs4906336 chr14:104033265 C/G cg08213375 chr14:104286397 PPP1R13B 0.39 6.33 0.33 7.82e-10 Reticulocyte count; LUSC cis rs911119 0.866 rs6048925 chr20:23579056 C/A cg16589663 chr20:23618590 CST3 0.6 7.17 0.37 4.97e-12 Chronic kidney disease; LUSC cis rs983392 0.649 rs7936120 chr11:60000574 T/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.97 -0.31 6.15e-9 Alzheimer's disease (late onset); LUSC cis rs1044826 0.619 rs57357132 chr3:139118358 A/T cg15131784 chr3:139108705 COPB2 -0.42 -6.95 -0.36 1.89e-11 Obesity-related traits; LUSC cis rs1983170 1.000 rs483532 chr1:91980447 A/G cg25838465 chr1:92012736 NA -0.45 -6.3 -0.33 9.58e-10 Eosinophil percentage of white cells; LUSC cis rs478304 0.651 rs11227279 chr11:65495211 G/A cg27068330 chr11:65405492 SIPA1 -0.76 -10.93 -0.51 5.64e-24 Acne (severe); LUSC cis rs10740039 0.842 rs2119913 chr10:62395389 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs447735 0.587 rs258335 chr16:89720944 G/A cg04240660 chr16:89714849 CHMP1A -0.45 -7.13 -0.36 6.17e-12 Hemoglobin concentration; LUSC cis rs13256369 0.802 rs12541520 chr8:8564146 G/T cg17143192 chr8:8559678 CLDN23 0.62 9.13 0.45 6.45e-18 Obesity-related traits; LUSC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg20908204 chr19:46285434 DMPK 0.41 8.24 0.41 4.04e-15 Coronary artery disease; LUSC cis rs9902453 0.791 rs3098950 chr17:27998385 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.19 0.52 6.75e-25 Coffee consumption (cups per day); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg18530950 chr2:128284093 IWS1 -0.47 -5.94 -0.31 7.02e-9 Height; LUSC cis rs11626933 1.000 rs11626016 chr14:90747979 C/T cg14092571 chr14:90743983 NA -0.89 -18.83 -0.72 2.03e-54 Gut microbiota (bacterial taxa); LUSC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg06108461 chr20:60628389 TAF4 -1.01 -17.17 -0.68 8.19e-48 Body mass index; LUSC cis rs12210905 0.610 rs12216370 chr6:26878930 T/C cg23155468 chr6:27110703 HIST1H2BK -0.64 -5.66 -0.3 3.25e-8 Hip circumference adjusted for BMI; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20386705 chr6:38607295 BTBD9 0.42 5.96 0.31 6.3e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6998277 0.830 rs6981007 chr8:103598257 G/C cg10187029 chr8:103597600 NA 0.77 11.83 0.54 3.41e-27 Migraine; LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg25036284 chr2:26402008 FAM59B -0.74 -10.56 -0.5 1.13e-22 Gut microbiome composition (summer); LUSC cis rs10484885 0.775 rs72919985 chr6:90534641 A/G cg13799429 chr6:90582589 CASP8AP2 -0.85 -7.99 -0.4 2.23e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs5997397 0.934 rs6005863 chr22:29156448 A/G cg02153584 chr22:29168773 CCDC117 0.5 7.75 0.39 1.08e-13 Red cell distribution width; LUSC cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg00321850 chr1:175162397 KIAA0040 -0.46 -7.88 -0.4 4.74e-14 Alcohol dependence; LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.78 -0.57 1.02e-30 Platelet count; LUSC cis rs1577917 0.771 rs9362230 chr6:86305013 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.88 -0.51 8.15e-24 Response to antipsychotic treatment; LUSC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11644478 chr21:40555479 PSMG1 -0.61 -9.53 -0.46 3.45e-19 Menarche (age at onset); LUSC cis rs7954584 0.626 rs10840637 chr12:122427310 A/G cg01765077 chr12:122356316 WDR66 0.5 7.12 0.36 6.81e-12 Mean corpuscular volume; LUSC cis rs2795502 0.564 rs11239844 chr10:43453365 G/A cg08461752 chr10:43522343 NA -0.53 -6.52 -0.34 2.63e-10 Blood protein levels; LUSC cis rs9325144 0.560 rs1825802 chr12:38650341 C/T cg26384229 chr12:38710491 ALG10B -0.67 -10.52 -0.5 1.46e-22 Morning vs. evening chronotype; LUSC cis rs4474465 1.000 rs7950813 chr11:78215082 A/T cg27205649 chr11:78285834 NARS2 0.53 6.07 0.32 3.38e-9 Alzheimer's disease (survival time); LUSC cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg09626299 chr10:82213104 TSPAN14 -0.2 -6.01 -0.31 4.78e-9 Post bronchodilator FEV1; LUSC cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg23583168 chr7:148888333 NA -0.82 -14.59 -0.62 1.25e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg05457628 chr5:178986728 RUFY1 0.56 9.58 0.46 2.29e-19 Lung cancer; LUSC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg17554472 chr22:41940697 POLR3H -0.47 -5.73 -0.3 2.29e-8 Vitiligo; LUSC cis rs56399783 0.901 rs56007918 chr7:2826205 A/G cg14895029 chr7:2775587 GNA12 0.51 6.31 0.33 9.01e-10 Childhood ear infection; LUSC cis rs2219968 0.692 rs9657044 chr8:78942084 A/G cg00738934 chr8:78996279 NA -0.4 -7.22 -0.37 3.56e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4343996 0.754 rs7789887 chr7:3350051 C/G cg21248987 chr7:3385318 SDK1 0.37 6.27 0.32 1.14e-9 Motion sickness; LUSC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg03676636 chr4:99064102 C4orf37 0.35 7.79 0.39 8.28e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs13082711 0.863 rs34611823 chr3:27500344 A/G cg02860705 chr3:27208620 NA 0.49 8.41 0.42 1.18e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC trans rs1552272 1.000 rs1552272 chr16:85452695 A/G cg08438366 chr20:37230612 C20orf95 0.28 6.0 0.31 5.13e-9 Platelet distribution width; LUSC cis rs6121246 0.567 rs6060399 chr20:30220823 C/T cg13852791 chr20:30311386 BCL2L1 0.79 8.89 0.44 3.84e-17 Mean corpuscular hemoglobin; LUSC cis rs4730250 0.707 rs6977868 chr7:106790555 T/G cg02696742 chr7:106810147 HBP1 0.65 9.18 0.45 4.72e-18 Osteoarthritis; LUSC cis rs2635047 0.811 rs12962421 chr18:44787498 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 5.7 0.3 2.68e-8 Educational attainment; LUSC trans rs5756813 0.688 rs12484064 chr22:38126746 C/A cg19894588 chr14:64061835 NA -0.52 -6.7 -0.34 9.13e-11 Optic cup area;Vertical cup-disc ratio; LUSC cis rs7089973 0.523 rs7093330 chr10:116744574 T/A cg23260525 chr10:116636907 FAM160B1 0.3 5.79 0.3 1.61e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg07701084 chr6:150067640 NUP43 0.57 8.87 0.44 4.55e-17 Lung cancer; LUSC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.3 -0.37 2.16e-12 Extrinsic epigenetic age acceleration; LUSC cis rs5769707 0.521 rs5769719 chr22:50062101 G/A cg10356904 chr22:49881777 NA -0.29 -5.78 -0.3 1.75e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6942756 1.000 rs6467235 chr7:128939150 A/G cg02491457 chr7:128862824 NA 0.46 5.92 0.31 7.84e-9 White matter hyperintensity burden; LUSC cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg22676075 chr6:135203613 NA 0.59 9.48 0.46 5e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs16854884 0.837 rs6767236 chr3:143758399 A/C cg06585982 chr3:143692056 C3orf58 0.47 6.95 0.36 1.96e-11 Economic and political preferences (feminism/equality); LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg10360139 chr7:1886902 MAD1L1 -0.38 -5.68 -0.3 2.87e-8 Bipolar disorder and schizophrenia; LUSC trans rs208520 0.909 rs9354411 chr6:67019930 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 8.87 0.44 4.63e-17 Exhaled nitric oxide output; LUSC cis rs977987 0.800 rs1011121 chr16:75325933 A/G cg04384234 chr16:75411784 CFDP1 -0.38 -6.04 -0.31 4.05e-9 Dupuytren's disease; LUSC cis rs11250098 0.526 rs116793410 chr8:10770255 G/T cg27411982 chr8:10470053 RP1L1 -0.45 -6.73 -0.35 7.5e-11 Morning vs. evening chronotype; LUSC cis rs6121246 0.523 rs6060286 chr20:30197663 C/A cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg22903657 chr4:1355424 KIAA1530 -0.38 -6.2 -0.32 1.65e-9 Longevity; LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg15790184 chr11:494944 RNH1 0.53 6.01 0.31 4.84e-9 Body mass index; LUSC trans rs459571 0.959 rs2520100 chr9:136918137 A/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -12.41 -0.56 2.38e-29 Platelet distribution width; LUSC cis rs6733011 0.578 rs1581251 chr2:99500867 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.98 -0.36 1.57e-11 Bipolar disorder; LUSC trans rs11039798 0.507 rs56994343 chr11:48896970 G/A cg15704280 chr7:45808275 SEPT13 0.75 8.33 0.41 2.14e-15 Axial length; LUSC cis rs10887741 0.546 rs7078618 chr10:89440911 A/G cg13926569 chr10:89418898 PAPSS2 0.26 5.72 0.3 2.32e-8 Exercise (leisure time); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg02551882 chr22:31365455 MORC2;TUG1 0.76 6.44 0.33 4.21e-10 Body mass index; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg06446895 chr17:79829189 ARHGDIA -0.38 -6.64 -0.34 1.26e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9837602 1.000 rs1688771 chr3:99503359 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -6.04 -0.31 4.08e-9 Breast cancer; LUSC cis rs3126085 0.825 rs11204938 chr1:152193990 A/G cg03465714 chr1:152285911 FLG -0.41 -5.89 -0.31 9.28e-9 Atopic dermatitis; LUSC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 8.11 0.41 9.9e-15 Bipolar disorder; LUSC cis rs7267979 0.789 rs6050472 chr20:25219852 A/G cg08601574 chr20:25228251 PYGB 0.52 8.18 0.41 5.81e-15 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1997103 1.000 rs6945937 chr7:55407140 C/T cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs367615 0.704 rs60538082 chr5:108829101 A/G cg17395555 chr5:108820864 NA 0.64 11.56 0.53 3.06e-26 Colorectal cancer (SNP x SNP interaction); LUSC cis rs6489882 0.703 rs10850093 chr12:113360468 C/T cg20102336 chr12:113376681 OAS3 -0.4 -5.71 -0.3 2.46e-8 Chronic lymphocytic leukemia; LUSC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg05585544 chr11:47624801 NA -0.41 -7.23 -0.37 3.22e-12 Subjective well-being; LUSC cis rs9287719 0.967 rs10929682 chr2:10732189 C/A cg00105475 chr2:10696890 NA 0.36 5.95 0.31 6.6e-9 Prostate cancer; LUSC trans rs208520 0.690 rs207114 chr6:66791703 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -17.07 -0.68 2.08e-47 Exhaled nitric oxide output; LUSC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg01475377 chr6:109611718 NA -0.47 -8.65 -0.43 2.25e-16 Reticulocyte fraction of red cells; LUSC cis rs977987 0.750 rs4888407 chr16:75432390 T/C cg03315344 chr16:75512273 CHST6 0.52 10.09 0.48 4.42e-21 Dupuytren's disease; LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 12.88 0.58 4.13e-31 Platelet count; LUSC cis rs10911232 0.507 rs4652762 chr1:182993960 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs10193935 0.901 rs7594010 chr2:42534896 C/T cg27598129 chr2:42591480 NA -0.6 -8.2 -0.41 5.18e-15 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.697 rs35280960 chr4:120257059 G/A cg25214090 chr10:38739885 LOC399744 0.41 6.12 0.32 2.67e-9 Corneal astigmatism; LUSC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg20243544 chr17:37824526 PNMT -0.38 -5.78 -0.3 1.72e-8 Self-reported allergy; LUSC cis rs1577917 0.771 rs2842609 chr6:86296788 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.68 -10.82 -0.51 1.33e-23 Response to antipsychotic treatment; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg10802521 chr3:52805072 NEK4 -0.52 -8.23 -0.41 4.3e-15 Bipolar disorder; LUSC trans rs970548 0.688 rs10900228 chr10:46082128 A/G cg20477318 chr10:51623047 TIMM23 0.58 5.96 0.31 6.38e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs7577696 0.626 rs3769603 chr2:32360887 G/T cg02381751 chr2:32503542 YIPF4 -0.45 -6.27 -0.32 1.12e-9 Inflammatory biomarkers; LUSC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs7592578 0.508 rs55919641 chr2:191265414 G/A cg10560079 chr2:191398806 TMEM194B -0.51 -6.63 -0.34 1.39e-10 Diastolic blood pressure; LUSC cis rs9527 0.590 rs10883829 chr10:104840635 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -6.89 -0.35 2.73e-11 Arsenic metabolism; LUSC cis rs12594515 1.000 rs8031128 chr15:45988528 C/G cg06207120 chr15:45996521 NA 0.39 6.09 0.32 3.08e-9 Waist circumference;Weight; LUSC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg24531977 chr5:56204891 C5orf35 -1.04 -15.68 -0.65 6.73e-42 Initial pursuit acceleration; LUSC cis rs9911578 0.785 rs10853008 chr17:56993407 T/C cg05425664 chr17:57184151 TRIM37 0.58 8.01 0.4 1.96e-14 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23329156 chr3:190231815 IL1RAP -0.45 -6.55 -0.34 2.15e-10 Electrocardiographic conduction measures; LUSC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg03396347 chr1:1875803 NA -0.53 -11.79 -0.54 4.59e-27 Body mass index; LUSC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg05340658 chr4:99064831 C4orf37 0.64 10.99 0.52 3.39e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.930 rs2287276 chr2:15660254 A/G cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs6901250 0.851 rs607372 chr6:117155929 A/G cg12892004 chr6:117198278 RFX6 -0.44 -8.21 -0.41 4.87e-15 C-reactive protein levels; LUSC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.09 14.43 0.62 5.1e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6952808 1.000 rs12540579 chr7:1882227 C/A cg24247370 chr13:99142703 STK24 -0.34 -6.17 -0.32 2e-9 Bipolar disorder and schizophrenia; LUSC cis rs9326248 0.581 rs7120706 chr11:116830087 C/T cg26566898 chr11:117069891 TAGLN -0.35 -6.67 -0.34 1.04e-10 Blood protein levels; LUSC cis rs13161895 1.000 rs4129403 chr5:179476610 A/G cg02702477 chr5:179499311 RNF130 0.5 5.7 0.3 2.67e-8 LDL cholesterol; LUSC cis rs4409675 0.576 rs2295367 chr1:28224312 C/T cg23691781 chr1:28212827 C1orf38 0.3 7.25 0.37 2.98e-12 Corneal astigmatism; LUSC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg25019033 chr10:957182 NA -0.51 -6.36 -0.33 6.56e-10 Eosinophil percentage of granulocytes; LUSC cis rs7586879 0.828 rs11685125 chr2:25092104 A/G cg01884057 chr2:25150051 NA 0.4 8.18 0.41 5.98e-15 Body mass index; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02410524 chr20:36156167 BLCAP 0.72 6.33 0.33 7.87e-10 Cognitive performance; LUSC trans rs7786808 0.741 rs7789415 chr7:158227617 C/T cg02030672 chr11:45687055 CHST1 0.43 6.44 0.33 4.05e-10 Obesity-related traits; LUSC cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg21427119 chr20:30132790 HM13 -0.38 -5.91 -0.31 8.67e-9 Mean corpuscular hemoglobin; LUSC trans rs10097669 0.642 rs2725069 chr8:4439602 T/G cg16451306 chr5:71475356 MAP1B 0.29 5.95 0.31 6.75e-9 Trans fatty acid levels; LUSC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg16606324 chr3:10149918 C3orf24 0.63 8.88 0.44 4.09e-17 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05263790 chr21:38739726 DYRK1A 0.47 6.44 0.33 4.25e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs62400317 0.762 rs12215263 chr6:44831364 C/A cg20913747 chr6:44695427 NA -0.48 -7.5 -0.38 5.98e-13 Total body bone mineral density; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20243626 chr1:220263520 BPNT1 0.44 6.36 0.33 6.6e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg16606324 chr3:10149918 C3orf24 0.58 8.37 0.42 1.55e-15 Alzheimer's disease; LUSC trans rs9929218 0.953 rs9927329 chr16:68750331 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -13.08 -0.58 7.28e-32 Colorectal cancer; LUSC cis rs4919687 0.550 rs17784294 chr10:104479385 G/T cg04362960 chr10:104952993 NT5C2 0.45 6.46 0.33 3.78e-10 Colorectal cancer; LUSC cis rs8060686 0.516 rs73612297 chr16:68284754 T/G cg09835421 chr16:68378352 PRMT7 -0.51 -6.24 -0.32 1.33e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2274273 0.837 rs10131913 chr14:55787420 A/G cg04306507 chr14:55594613 LGALS3 0.56 12.99 0.58 1.58e-31 Protein biomarker; LUSC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg09904177 chr6:26538194 HMGN4 -0.53 -6.18 -0.32 1.91e-9 Intelligence (multi-trait analysis); LUSC cis rs9361491 0.657 rs9341742 chr6:79440229 C/T cg05283184 chr6:79620031 NA -0.34 -6.2 -0.32 1.66e-9 Intelligence (multi-trait analysis); LUSC cis rs7428 0.527 rs6547612 chr2:85551184 C/T cg24342717 chr2:85555507 TGOLN2 -0.76 -12.6 -0.57 4.93e-30 Ear protrusion; LUSC cis rs7577851 0.672 rs12477398 chr2:69628491 T/G cg10773587 chr2:69614142 GFPT1 0.56 6.3 0.33 9.29e-10 Parkinson's disease (age of onset); LUSC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.69 -0.34 9.49e-11 Alzheimer's disease (late onset); LUSC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.59 -0.5 8.37e-23 Gut microbiome composition (summer); LUSC cis rs921665 0.831 rs2167962 chr2:3192427 G/A cg16434511 chr2:3151078 NA -0.61 -6.86 -0.35 3.42e-11 World class endurance athleticism; LUSC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg11062466 chr8:58055876 NA 0.67 8.06 0.4 1.41e-14 Developmental language disorder (linguistic errors); LUSC cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg03146154 chr1:46216737 IPP -0.51 -7.57 -0.38 3.61e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9287719 0.967 rs4669598 chr2:10757838 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2050392 1.000 rs2183176 chr10:30698544 C/T cg18806716 chr10:30721971 MAP3K8 0.48 7.95 0.4 2.82e-14 Inflammatory bowel disease; LUSC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs6495122 0.501 rs6495144 chr15:75343438 T/C cg09165964 chr15:75287851 SCAMP5 -0.47 -6.84 -0.35 3.71e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC trans rs1422110 0.513 rs1422105 chr5:85448371 A/C cg01787110 chr1:109008453 NBPF6 0.44 8.08 0.4 1.16e-14 Attention function in attention deficit hyperactive disorder; LUSC cis rs1577917 0.655 rs7742691 chr6:86278691 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 9.31 0.45 1.72e-18 Response to antipsychotic treatment; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg24642844 chr7:1081250 C7orf50 -0.8 -11.08 -0.52 1.72e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2249625 0.504 rs2496508 chr6:72891398 A/G cg18830697 chr6:72922368 RIMS1 -0.38 -7.64 -0.39 2.39e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs6700896 0.500 rs11208699 chr1:66131377 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs7951105 1.000 rs12099337 chr11:39242600 C/A cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg19774624 chr17:42201019 HDAC5 -0.81 -13.41 -0.59 4.34e-33 Total body bone mineral density; LUSC cis rs10743315 0.643 rs75189071 chr12:19329505 C/T cg02471346 chr12:19282374 PLEKHA5 0.78 6.14 0.32 2.29e-9 Gut microbiota (bacterial taxa); LUSC trans rs11039571 0.544 rs7947811 chr11:48167738 C/T cg15704280 chr7:45808275 SEPT13 -0.62 -6.97 -0.36 1.68e-11 D-dimer levels; LUSC cis rs62400317 0.859 rs114017772 chr6:45113862 T/C cg18551225 chr6:44695536 NA -0.42 -6.82 -0.35 4.2e-11 Total body bone mineral density; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg13685833 chr1:53393034 SCP2 -0.39 -5.86 -0.31 1.11e-8 Monocyte count; LUSC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.81e-12 Depression; LUSC cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs727505 1.000 rs10265763 chr7:124451514 G/A cg23710748 chr7:124431027 NA -0.42 -7.57 -0.38 3.56e-13 Lewy body disease; LUSC cis rs11148252 0.669 rs4884320 chr13:53006914 T/C cg02158880 chr13:53174818 NA 0.41 5.96 0.31 6.35e-9 Lewy body disease; LUSC cis rs4014195 0.521 rs12576996 chr11:65580638 G/T cg27068330 chr11:65405492 SIPA1 0.68 8.54 0.42 4.67e-16 Glomerular filtration rate (creatinine);Chronic kidney disease; LUSC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg16447950 chr5:562315 NA -0.57 -6.95 -0.36 1.97e-11 Lung disease severity in cystic fibrosis; LUSC cis rs11822910 0.953 rs11827928 chr11:57197890 A/G cg00522883 chr11:57194120 SLC43A3 0.45 6.39 0.33 5.67e-10 Platelet distribution width; LUSC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.39 -0.37 1.19e-12 Menarche (age at onset); LUSC cis rs478304 0.900 rs502468 chr11:65525119 T/G cg05805236 chr11:65401703 PCNXL3 0.4 6.84 0.35 3.82e-11 Acne (severe); LUSC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg20933634 chr6:27740509 NA 0.41 5.85 0.31 1.15e-8 Parkinson's disease; LUSC cis rs9309711 0.621 rs12993215 chr2:3473727 T/C cg08493051 chr2:3487164 NA -0.51 -7.8 -0.39 8.08e-14 Neurofibrillary tangles; LUSC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg00815214 chr21:47717953 NA -0.35 -5.65 -0.3 3.42e-8 Testicular germ cell tumor; LUSC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg02574844 chr11:5959923 NA -0.43 -6.13 -0.32 2.54e-9 DNA methylation (variation); LUSC cis rs1595825 0.891 rs16824376 chr2:198684342 C/T cg00982548 chr2:198649783 BOLL -0.59 -7.27 -0.37 2.62e-12 Ulcerative colitis; LUSC cis rs1322512 0.837 rs2800627 chr6:153006507 C/A cg27316956 chr6:152958899 SYNE1 0.35 6.09 0.32 3.07e-9 Tonometry; LUSC cis rs3125734 0.633 rs4979773 chr10:63967731 G/C cg19640130 chr10:64028056 RTKN2 -0.41 -7.31 -0.37 1.98e-12 Rheumatoid arthritis; LUSC cis rs6754311 0.550 rs12994270 chr2:136518103 T/A cg07169764 chr2:136633963 MCM6 -0.59 -7.76 -0.39 1.02e-13 Mosquito bite size; LUSC cis rs9369695 0.842 rs9395262 chr6:47465267 T/C cg20196966 chr6:47445060 CD2AP 0.42 5.81 0.3 1.49e-8 Reticulocyte count; LUSC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC cis rs7208859 0.524 rs60114476 chr17:29097667 A/T cg13385521 chr17:29058706 SUZ12P 0.69 6.79 0.35 5.27e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7923609 0.841 rs10740131 chr10:65271488 A/T cg01631684 chr10:65280961 REEP3 -0.42 -6.43 -0.33 4.35e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg18099408 chr3:52552593 STAB1 -0.41 -7.04 -0.36 1.07e-11 Bipolar disorder; LUSC cis rs2820315 0.867 rs2819351 chr1:201885157 C/T cg10061532 chr1:201886748 LMOD1 0.28 6.41 0.33 5.09e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs9467773 0.525 rs1535274 chr6:26520747 A/C cg11502198 chr6:26597334 ABT1 0.75 11.72 0.54 8.53e-27 Intelligence (multi-trait analysis); LUSC trans rs67340775 0.541 rs200975 chr6:27855625 G/T cg05267876 chr1:229644265 NUP133 -0.56 -6.08 -0.32 3.25e-9 Lung cancer in ever smokers; LUSC cis rs11190604 0.943 rs3750632 chr10:102279295 G/C cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.8 8.04 0.4 1.62e-14 Lung cancer in ever smokers; LUSC cis rs887829 0.667 rs7577677 chr2:234590616 C/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.41 -6.54 -0.34 2.35e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs208520 0.526 rs7775830 chr6:66755249 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.2 24.22 0.8 1.65e-75 Exhaled nitric oxide output; LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg11494091 chr17:61959527 GH2 0.65 13.92 0.61 4.91e-35 Prudent dietary pattern; LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg03526776 chr6:41159608 TREML2 0.5 9.77 0.47 5.48e-20 Alzheimer's disease (late onset); LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg02951883 chr7:2050386 MAD1L1 -0.46 -8.03 -0.4 1.74e-14 Bipolar disorder and schizophrenia; LUSC trans rs61931739 0.517 rs11052977 chr12:34035030 A/C cg13010199 chr12:38710504 ALG10B 0.55 8.3 0.41 2.7e-15 Morning vs. evening chronotype; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.47 5.84 0.3 1.21e-8 Renal function-related traits (BUN); LUSC cis rs10754283 0.901 rs6663526 chr1:90110862 T/C cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs1376359 0.503 rs610502 chr1:103274928 A/C cg17154563 chr19:40477487 PSMC4 0.47 5.97 0.31 5.95e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.98 -0.31 5.72e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10992471 0.603 rs10992349 chr9:95233887 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.68 -0.39 1.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg14664628 chr15:75095509 CSK -0.55 -8.46 -0.42 8.72e-16 Breast cancer; LUSC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg24675056 chr1:15929824 NA 0.48 8.24 0.41 3.92e-15 Systolic blood pressure; LUSC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg24531977 chr5:56204891 C5orf35 -1.0 -14.93 -0.63 5.9e-39 Initial pursuit acceleration; LUSC cis rs7103648 1.000 rs10838709 chr11:47447346 C/T cg20307385 chr11:47447363 PSMC3 0.99 19.53 0.73 3.23e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg05025164 chr4:1340916 KIAA1530 0.46 7.07 0.36 9.08e-12 Obesity-related traits; LUSC cis rs12594515 1.000 rs8039974 chr15:45986665 A/G cg19682013 chr15:45996608 NA 0.39 5.9 0.31 8.82e-9 Waist circumference;Weight; LUSC cis rs7769051 0.522 rs6934155 chr6:133124021 C/T cg22852734 chr6:133119734 C6orf192 1.33 10.41 0.49 3.74e-22 Type 2 diabetes nephropathy; LUSC cis rs1670533 1.000 rs10084849 chr4:1053586 T/C cg27284194 chr4:1044797 NA 0.59 8.97 0.44 2.1e-17 Recombination rate (females); LUSC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg04362960 chr10:104952993 NT5C2 0.58 8.22 0.41 4.55e-15 Arsenic metabolism; LUSC trans rs8072100 0.817 rs9905581 chr17:45547185 C/T cg04995722 chr7:26192034 NFE2L3 -0.43 -6.7 -0.34 8.92e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg11790438 chr9:140317161 NOXA1;EXD3 0.42 6.32 0.33 8.17e-10 Metabolite levels (Pyroglutamine); LUSC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg18196295 chr10:418757 DIP2C -0.51 -8.5 -0.42 6.37e-16 Psychosis in Alzheimer's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11087358 chr12:57940980 DCTN2 0.46 6.65 0.34 1.18e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3824867 0.920 rs7107853 chr11:47453518 T/C cg20307385 chr11:47447363 PSMC3 -0.65 -9.65 -0.47 1.35e-19 Mean corpuscular hemoglobin; LUSC cis rs9462027 0.628 rs2814942 chr6:34644261 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.28 -0.32 1.07e-9 Systemic lupus erythematosus; LUSC cis rs760805 1.000 rs10903115 chr1:25261696 A/G cg22509179 chr1:25234806 RUNX3 -0.6 -10.51 -0.5 1.63e-22 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11608355 0.515 rs1045263 chr12:109974191 A/G cg05360138 chr12:110035743 NA 0.93 12.3 0.56 5.99e-29 Neuroticism; LUSC cis rs7208859 0.573 rs8064686 chr17:29134839 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.62 -0.34 1.44e-10 Monocyte percentage of white cells; LUSC trans rs7726839 0.540 rs12517638 chr5:645484 C/T cg25482853 chr8:67687455 SGK3 1.1 15.65 0.65 8.75e-42 Obesity-related traits; LUSC cis rs3820928 0.874 rs2272198 chr2:227893017 A/G cg11843606 chr2:227700838 RHBDD1 0.51 7.51 0.38 5.31e-13 Pulmonary function; LUSC cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.06 0.4 1.35e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs508618 0.731 rs12033229 chr1:231545703 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.56 6.83 0.35 4.01e-11 Red blood cell count; LUSC cis rs6918586 0.658 rs198813 chr6:26128226 C/T cg17691542 chr6:26056736 HIST1H1C 0.4 5.97 0.31 5.96e-9 Schizophrenia; LUSC trans rs12210905 0.858 rs72838249 chr6:26998489 A/G cg11837749 chr1:55047332 ACOT11 0.57 6.13 0.32 2.51e-9 Hip circumference adjusted for BMI; LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.58 0.38 3.35e-13 Prudent dietary pattern; LUSC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg11764359 chr7:65958608 NA 0.63 9.61 0.47 1.85e-19 Aortic root size; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg01655898 chr14:21439243 NA 0.43 6.66 0.34 1.12e-10 N-glycan levels; LUSC trans rs656319 0.559 rs17689037 chr8:9974858 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.6 -0.34 1.65e-10 Myopia (pathological); LUSC cis rs936229 0.749 rs8042694 chr15:75225415 G/A cg10253484 chr15:75165896 SCAMP2 -0.58 -7.8 -0.39 7.76e-14 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs4595586 0.545 rs1839402 chr12:39371615 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.01 0.31 4.72e-9 Morning vs. evening chronotype; LUSC cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg04586622 chr2:25135609 ADCY3 0.43 9.22 0.45 3.32e-18 Body mass index; LUSC cis rs16976116 0.851 rs13380400 chr15:55490518 A/G cg11288833 chr15:55489084 RSL24D1 0.5 5.98 0.31 5.65e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg16423285 chr20:60520624 NA -0.47 -5.92 -0.31 8.15e-9 Body mass index; LUSC cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg09323728 chr8:95962352 TP53INP1 -0.45 -9.37 -0.46 1.1e-18 Type 2 diabetes; LUSC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg26335602 chr6:28129616 ZNF389 0.41 5.78 0.3 1.74e-8 Parkinson's disease; LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.19 -0.32 1.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6977660 0.714 rs12536561 chr7:19816659 G/A cg05791153 chr7:19748676 TWISTNB 0.68 7.22 0.37 3.49e-12 Thyroid stimulating hormone; LUSC cis rs1448094 1.000 rs10083080 chr12:86348579 G/C cg18827107 chr12:86230957 RASSF9 -0.4 -5.96 -0.31 6.38e-9 Major depressive disorder; LUSC cis rs459571 0.883 rs2520096 chr9:136919416 A/G cg13789015 chr9:136890014 NCRNA00094 0.66 12.24 0.56 1.02e-28 Platelet distribution width; LUSC cis rs6960043 0.791 rs2191346 chr7:15053878 C/G cg19272540 chr7:15055459 NA -0.33 -8.22 -0.41 4.41e-15 Type 2 diabetes; LUSC trans rs2587949 0.571 rs2248969 chr3:4230023 T/C cg15139668 chr4:4577005 NA -0.42 -6.13 -0.32 2.49e-9 Periodontitis (DPAL); LUSC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg17971929 chr21:40555470 PSMG1 0.8 13.99 0.61 2.6e-35 Cognitive function; LUSC cis rs9302635 0.513 rs3812987 chr16:72158920 C/A cg01557791 chr16:72042693 DHODH -0.49 -6.49 -0.33 3.12e-10 Blood protein levels; LUSC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg10523679 chr1:76189770 ACADM 0.86 14.2 0.61 4.1e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg11764359 chr7:65958608 NA 0.63 9.66 0.47 1.2e-19 Aortic root size; LUSC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg16145915 chr7:1198662 ZFAND2A -0.41 -6.06 -0.31 3.65e-9 Bronchopulmonary dysplasia; LUSC cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg14689365 chr7:158441557 NCAPG2 -0.45 -6.13 -0.32 2.55e-9 Height; LUSC cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg17420585 chr12:42539391 GXYLT1 -0.4 -8.02 -0.4 1.82e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs17255340 0.501 rs1145916 chr6:83988986 G/T cg08257003 chr6:84140564 ME1 0.33 8.04 0.4 1.59e-14 Platelet-derived growth factor BB levels; LUSC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg17366294 chr4:99064904 C4orf37 0.56 10.0 0.48 8.92e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9300255 0.566 rs10744150 chr12:123721614 A/C cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.78 -0.35 5.48e-11 Neutrophil percentage of white cells; LUSC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg00074818 chr8:8560427 CLDN23 0.57 9.81 0.47 4.05e-20 Obesity-related traits; LUSC cis rs4727027 0.870 rs13237714 chr7:148884083 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.36 0.33 6.75e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs17021463 0.902 rs2865352 chr4:95253263 A/G cg11021082 chr4:95130006 SMARCAD1 -0.38 -7.04 -0.36 1.08e-11 Testicular germ cell tumor; LUSC cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg12219531 chr12:120966889 COQ5 0.61 8.11 0.41 9.99e-15 High light scatter reticulocyte count; LUSC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -12.61 -0.57 4.44e-30 Type 2 diabetes; LUSC cis rs2019216 0.500 rs71371082 chr17:21889647 T/C cg22648282 chr17:21454238 C17orf51 -0.54 -7.82 -0.39 6.97e-14 Pelvic organ prolapse; LUSC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg23630131 chr7:65973040 NA 0.2 5.73 0.3 2.29e-8 Aortic root size; LUSC cis rs11122272 0.735 rs2739507 chr1:231527329 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.91 0.48 1.86e-20 Hemoglobin concentration; LUSC cis rs11650494 0.908 rs75904857 chr17:47370449 T/G cg08112188 chr17:47440006 ZNF652 1.22 10.51 0.5 1.6e-22 Prostate cancer; LUSC cis rs12220238 1.000 rs11000905 chr10:75925532 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.88 0.35 2.97e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg22532475 chr10:104410764 TRIM8 -0.35 -7.76 -0.39 1.01e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19346786 chr7:2764209 NA -0.39 -6.8 -0.35 4.84e-11 Height; LUSC cis rs7727544 0.606 rs17622208 chr5:131717050 G/A cg09877947 chr5:131593287 PDLIM4 0.41 6.68 0.34 1.03e-10 Blood metabolite levels; LUSC cis rs7089973 0.549 rs34434610 chr10:116739745 A/G cg23260525 chr10:116636907 FAM160B1 0.29 5.71 0.3 2.43e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs8017423 1.000 rs11622075 chr14:90669894 G/T cg04374321 chr14:90722782 PSMC1 0.69 10.89 0.51 7.84e-24 Mortality in heart failure; LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg03188948 chr7:1209495 NA 0.66 6.92 0.35 2.35e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg14583973 chr4:3374767 RGS12 0.35 7.51 0.38 5.51e-13 Serum sulfate level; LUSC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.47 7.23 0.37 3.25e-12 Colorectal cancer; LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs4721295 0.546 rs1637766 chr7:2204400 G/A cg22963979 chr7:1858916 MAD1L1 0.4 5.91 0.31 8.33e-9 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs611744 0.573 rs1457210 chr8:109261562 A/G cg18478394 chr8:109455254 TTC35 -0.41 -6.56 -0.34 2.01e-10 Dupuytren's disease; LUSC cis rs7223966 1.000 rs55868506 chr17:61851686 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 7.0 0.36 1.39e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6545883 0.965 rs778752 chr2:61776902 C/G cg15711740 chr2:61764176 XPO1 -0.52 -8.47 -0.42 7.99e-16 Tuberculosis; LUSC cis rs2075371 0.611 rs12707154 chr7:134015832 C/T cg00033643 chr7:134001901 SLC35B4 0.42 6.07 0.32 3.5e-9 Mean platelet volume; LUSC cis rs9549367 0.713 rs3024761 chr13:113824090 C/G cg00898013 chr13:113819073 PROZ 0.67 9.46 0.46 5.87e-19 Platelet distribution width; LUSC cis rs9942416 0.533 rs4704235 chr5:75024380 A/C cg19683494 chr5:74908142 NA 0.48 6.74 0.35 7.12e-11 Age-related disease endophenotypes; LUSC cis rs2297440 0.527 rs4809318 chr20:62264760 G/A cg16989086 chr20:62203971 PRIC285 0.46 6.47 0.33 3.45e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.75 -0.35 6.53e-11 Monocyte percentage of white cells; LUSC cis rs1030268 0.651 rs13222377 chr7:133466346 C/T cg10665199 chr7:133106180 EXOC4 0.51 5.72 0.3 2.33e-8 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05654404 chr1:45452166 EIF2B3 0.48 7.41 0.38 1.06e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6752107 0.791 rs3792106 chr2:234190740 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 7.65 0.39 2.24e-13 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6754311 0.731 rs7579771 chr2:136580260 T/A cg07169764 chr2:136633963 MCM6 0.58 7.58 0.38 3.47e-13 Mosquito bite size; LUSC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg24531977 chr5:56204891 C5orf35 -0.85 -13.03 -0.58 1.12e-31 Coronary artery disease; LUSC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 6.31 0.33 8.74e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg09034736 chr1:150693464 HORMAD1 -0.4 -5.75 -0.3 2.05e-8 Tonsillectomy; LUSC cis rs6835098 1.000 rs10027708 chr4:174083116 T/C cg08422745 chr4:174089978 GALNT7 -0.84 -13.81 -0.6 1.25e-34 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.92 -0.35 2.31e-11 Alzheimer's disease (late onset); LUSC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg07741184 chr6:167504864 NA 0.4 7.14 0.36 5.87e-12 Crohn's disease; LUSC cis rs7617773 0.779 rs9833309 chr3:48327450 C/T cg20734569 chr3:48348370 SPINK8 -0.47 -8.17 -0.41 6.44e-15 Coronary artery disease; LUSC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg14830002 chr1:247616686 OR2B11 0.49 7.05 0.36 1.05e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.49 -7.62 -0.38 2.62e-13 Colorectal cancer; LUSC cis rs7712401 0.601 rs152039 chr5:122220665 C/T cg19077854 chr5:122220652 SNX24 0.42 9.49 0.46 4.54e-19 Mean platelet volume; LUSC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg18305652 chr10:134549665 INPP5A 0.45 6.76 0.35 6.08e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs13315871 0.929 rs9837903 chr3:58301906 A/T cg12435725 chr3:58293450 RPP14 -0.74 -7.47 -0.38 7.23e-13 Cholesterol, total; LUSC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.46 6.91 0.35 2.51e-11 Platelet count; LUSC cis rs11657217 0.638 rs4313839 chr17:77698619 C/T cg06901238 chr17:77706717 ENPP7 -0.5 -9.69 -0.47 1.01e-19 Diastolic blood pressure response to hydrochlorothiazide in hypertension; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06793798 chr10:62538126 CDK1;CDC2 0.43 6.44 0.33 4.14e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7296418 0.922 rs1790134 chr12:123697898 T/C cg13010344 chr12:123464640 ARL6IP4 -0.51 -7.97 -0.4 2.58e-14 Platelet count; LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.44 0.38 8.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs865483 0.895 rs853192 chr17:35821931 C/G cg06716730 chr17:35851459 DUSP14 0.27 6.03 0.31 4.28e-9 Monocyte count; LUSC cis rs7539542 0.556 rs10753926 chr1:202876085 C/T cg19681188 chr1:202830198 LOC148709 0.39 5.77 0.3 1.86e-8 Mean platelet volume; LUSC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.16e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg07936489 chr17:37558343 FBXL20 0.69 9.69 0.47 1.01e-19 Glomerular filtration rate (creatinine); LUSC cis rs9535307 0.929 rs6561550 chr13:50249423 C/T cg04663916 chr13:50265991 EBPL 0.49 5.7 0.3 2.63e-8 Obesity-related traits; LUSC cis rs12594515 1.000 rs6493167 chr15:45986809 G/A cg06207120 chr15:45996521 NA 0.4 6.23 0.32 1.38e-9 Waist circumference;Weight; LUSC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.57 9.07 0.44 1.02e-17 Total body bone mineral density; LUSC cis rs3820928 0.839 rs4675123 chr2:227800205 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.65 -0.39 2.11e-13 Pulmonary function; LUSC cis rs1561176 0.783 rs1124175 chr7:155015124 A/C cg08570118 chr7:155025533 NA 0.46 6.19 0.32 1.8e-9 Personality dimensions; LUSC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs1595825 0.891 rs60582020 chr2:198520555 A/C cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.34e-10 Ulcerative colitis; LUSC cis rs926392 0.896 rs7268772 chr20:37684501 A/G cg27552599 chr20:37590471 DHX35 0.34 5.94 0.31 6.98e-9 Dialysis-related mortality; LUSC cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.79 -0.54 4.47e-27 Chronic sinus infection; LUSC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg09913183 chr17:42254507 C17orf65;ASB16 0.56 8.42 0.42 1.1e-15 Total body bone mineral density; LUSC cis rs7561273 0.586 rs12477718 chr2:24330539 A/G cg20701182 chr2:24300061 SF3B14 0.51 6.55 0.34 2.19e-10 Quantitative traits; LUSC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg08677398 chr8:58056175 NA 0.44 6.05 0.31 3.87e-9 Developmental language disorder (linguistic errors); LUSC cis rs1670533 0.685 rs56019586 chr4:1059842 C/G cg02018176 chr4:1364513 KIAA1530 0.44 6.0 0.31 5.04e-9 Recombination rate (females); LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg15383120 chr6:291909 DUSP22 -0.66 -10.91 -0.51 6.8e-24 Menopause (age at onset); LUSC cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs9653442 0.545 rs12712067 chr2:100763900 A/C cg07810366 chr2:100720526 AFF3 0.44 7.37 0.37 1.34e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2742417 1.000 rs2673047 chr3:45743113 A/G cg04837898 chr3:45731254 SACM1L -0.35 -5.66 -0.3 3.28e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7107174 0.681 rs881337 chr11:78128335 G/C cg27205649 chr11:78285834 NARS2 -0.51 -5.87 -0.31 1.05e-8 Testicular germ cell tumor; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg03354898 chr7:1950403 MAD1L1 -0.32 -6.38 -0.33 5.9e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg22166914 chr1:53195759 ZYG11B -0.42 -6.22 -0.32 1.52e-9 Monocyte count; LUSC cis rs865483 0.895 rs4795200 chr17:35817105 A/G cg06716730 chr17:35851459 DUSP14 0.28 6.29 0.33 9.73e-10 Monocyte count; LUSC cis rs11051970 0.879 rs950080 chr12:32588503 G/A cg02745156 chr12:32552066 NA 0.43 7.29 0.37 2.29e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs208515 0.525 rs10944871 chr6:66690306 A/G cg07460842 chr6:66804631 NA 1.06 14.7 0.63 4.38e-38 Exhaled nitric oxide levels; LUSC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.82 -0.3 1.42e-8 Depression; LUSC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7119 0.717 rs12898281 chr15:77786903 C/T cg27398640 chr15:77910606 LINGO1 0.28 5.84 0.3 1.22e-8 Type 2 diabetes; LUSC cis rs477692 0.699 rs471357 chr10:131389373 C/G cg05714579 chr10:131428358 MGMT 0.45 6.3 0.33 9.35e-10 Response to temozolomide; LUSC trans rs6601450 0.522 rs7837979 chr8:10198534 C/T cg15556689 chr8:8085844 FLJ10661 0.45 6.81 0.35 4.53e-11 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg11645453 chr3:52864694 ITIH4 -0.49 -10.99 -0.52 3.31e-24 Schizophrenia; LUSC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -6.7 -0.34 8.86e-11 Major depressive disorder; LUSC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg11764359 chr7:65958608 NA -0.69 -10.77 -0.51 2.01e-23 Aortic root size; LUSC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg21017887 chr14:105400489 NA 0.69 13.27 0.59 1.45e-32 Rheumatoid arthritis; LUSC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg06494592 chr3:125709126 NA -0.49 -5.65 -0.3 3.46e-8 Blood pressure (smoking interaction); LUSC cis rs1801251 1.000 rs12990821 chr2:233617585 C/G cg08000102 chr2:233561755 GIGYF2 0.68 11.26 0.52 3.91e-25 Coronary artery disease; LUSC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg09365446 chr1:150670422 GOLPH3L -0.42 -6.24 -0.32 1.3e-9 Tonsillectomy; LUSC cis rs9733 0.681 rs7412746 chr1:150860471 C/T cg13175981 chr1:150552382 MCL1 0.46 6.39 0.33 5.67e-10 Tonsillectomy; LUSC cis rs7267979 1.000 rs2482927 chr20:25327151 T/C cg08601574 chr20:25228251 PYGB -0.42 -6.43 -0.33 4.42e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg16447950 chr5:562315 NA -0.59 -7.08 -0.36 8.42e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg24642439 chr20:33292090 TP53INP2 0.74 12.25 0.56 9.86e-29 Coronary artery disease; LUSC cis rs6782228 0.606 rs1127030 chr3:128338953 T/C cg16766828 chr3:128327626 NA -0.31 -5.66 -0.3 3.3e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs1499972 0.941 rs73168388 chr3:117645824 C/T cg07612923 chr3:117604196 NA 0.65 5.87 0.31 1.03e-8 Schizophrenia; LUSC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg16586182 chr3:47516702 SCAP 0.52 7.95 0.4 3e-14 Colorectal cancer; LUSC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg09455208 chr3:40491958 NA 0.54 9.73 0.47 7.2e-20 Renal cell carcinoma; LUSC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.91 -0.35 2.52e-11 Crohn's disease; LUSC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg06074448 chr4:187884817 NA -0.39 -6.52 -0.34 2.56e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg20503657 chr10:835505 NA 1.22 16.74 0.68 4.37e-46 Eosinophil percentage of granulocytes; LUSC cis rs2760061 0.599 rs644794 chr1:228148670 T/C cg01973587 chr1:228161476 NA 0.47 8.6 0.43 3.05e-16 Diastolic blood pressure; LUSC cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg13852791 chr20:30311386 BCL2L1 0.82 10.81 0.51 1.42e-23 Mean corpuscular hemoglobin; LUSC cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.68 -8.69 -0.43 1.69e-16 Chronic sinus infection; LUSC cis rs6504663 0.558 rs11871603 chr17:48559037 T/G cg03168497 chr17:48586147 MYCBPAP 0.5 6.66 0.34 1.15e-10 Visceral fat; LUSC cis rs950027 0.549 rs12909409 chr15:45608582 T/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.03 -0.4 1.68e-14 Response to fenofibrate (adiponectin levels); LUSC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg02423579 chr7:2872169 GNA12 -0.46 -6.5 -0.34 2.84e-10 Height; LUSC cis rs722599 0.748 rs17102884 chr14:75374899 C/T cg08847533 chr14:75593920 NEK9 -0.5 -7.19 -0.37 4.17e-12 IgG glycosylation; LUSC cis rs208520 0.690 rs12201219 chr6:66748862 A/T cg07460842 chr6:66804631 NA 1.1 17.27 0.69 3.31e-48 Exhaled nitric oxide output; LUSC cis rs12136530 0.774 rs883961 chr1:19781155 G/C cg01832549 chr1:19774989 CAPZB -0.32 -5.85 -0.3 1.15e-8 Lead levels in blood; LUSC cis rs6121246 0.529 rs7261354 chr20:30202414 T/C cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.23e-10 Mean corpuscular hemoglobin; LUSC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg04317338 chr11:64019027 PLCB3 0.68 7.7 0.39 1.52e-13 Mean platelet volume; LUSC cis rs11158026 0.722 rs2840268 chr14:55471983 C/G cg04306507 chr14:55594613 LGALS3 0.37 7.32 0.37 1.84e-12 Parkinson's disease; LUSC cis rs6733011 0.578 rs10169003 chr2:99508866 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.4 5.65 0.3 3.46e-8 Bipolar disorder; LUSC cis rs6669072 1.000 rs3904677 chr1:91252126 C/T cg08895590 chr1:91227319 NA -0.37 -8.2 -0.41 5.18e-15 Cognitive function; LUSC cis rs6665290 0.904 rs1343743 chr1:227183125 C/T cg10327440 chr1:227177885 CDC42BPA -1.21 -39.71 -0.91 1.49e-128 Myeloid white cell count; LUSC cis rs6545883 0.965 rs766447 chr2:61735569 C/T cg15711740 chr2:61764176 XPO1 -0.5 -7.97 -0.4 2.48e-14 Tuberculosis; LUSC cis rs62432291 0.681 rs423533 chr6:159664516 G/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.1 -0.32 2.86e-9 Joint mobility (Beighton score); LUSC cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.32 0.53 2.37e-25 Colorectal cancer; LUSC cis rs3740540 0.530 rs10794163 chr10:126291398 A/G cg04949429 chr10:126290192 LHPP 0.36 7.54 0.38 4.51e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs2692947 0.630 rs1168966 chr2:96798510 G/A cg22654517 chr2:96458247 NA 0.38 7.62 0.38 2.58e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg03233332 chr7:66118400 NA -0.41 -6.02 -0.31 4.61e-9 Aortic root size; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.28 0.56 7.31e-29 Prudent dietary pattern; LUSC cis rs877282 0.898 rs11253346 chr10:765313 A/G cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg12463550 chr7:65579703 CRCP 0.57 8.52 0.42 5.51e-16 Aortic root size; LUSC trans rs7980799 0.682 rs1601005 chr12:33634658 A/G cg13010199 chr12:38710504 ALG10B -0.42 -6.22 -0.32 1.49e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.96e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11809207 0.953 rs17163666 chr1:26525383 A/G cg00300879 chr1:26503847 CNKSR1 0.31 5.95 0.31 6.67e-9 Height; LUSC cis rs727505 0.866 rs67132333 chr7:124719801 A/G cg23710748 chr7:124431027 NA -0.4 -6.96 -0.36 1.79e-11 Lewy body disease; LUSC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.18e-11 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg15839431 chr19:19639596 YJEFN3 0.44 6.19 0.32 1.78e-9 Tonsillectomy; LUSC cis rs9399135 0.660 rs4267967 chr6:135272477 T/G cg22676075 chr6:135203613 NA 0.58 9.25 0.45 2.84e-18 Red blood cell count; LUSC cis rs7572644 0.766 rs2337372 chr2:28140349 G/A cg27432699 chr2:27873401 GPN1 0.52 6.43 0.33 4.31e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg00530320 chr1:46809349 NSUN4 0.55 8.47 0.42 7.65e-16 Menopause (age at onset); LUSC cis rs1018836 0.700 rs4735201 chr8:91528313 C/T cg16814680 chr8:91681699 NA -0.73 -11.41 -0.53 1.13e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg13010199 chr12:38710504 ALG10B 0.64 9.79 0.47 4.49e-20 Bladder cancer; LUSC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg24531977 chr5:56204891 C5orf35 -0.98 -14.56 -0.62 1.53e-37 Initial pursuit acceleration; LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 15.59 0.65 1.47e-41 Platelet count; LUSC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg20243544 chr17:37824526 PNMT 0.49 6.95 0.36 1.92e-11 Asthma; LUSC trans rs2197308 0.692 rs67352173 chr12:37906912 A/T cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.26e-10 Morning vs. evening chronotype; LUSC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg26513180 chr16:89883248 FANCA 0.63 5.86 0.31 1.11e-8 Skin colour saturation; LUSC cis rs950169 0.922 rs11635505 chr15:85097034 A/C cg17173187 chr15:85201210 NMB -0.37 -6.72 -0.34 8.03e-11 Schizophrenia; LUSC cis rs6554196 0.508 rs2237037 chr4:55525930 A/C cg18836493 chr4:55524333 KIT -0.44 -7.55 -0.38 4.21e-13 Monocyte count; LUSC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg11764359 chr7:65958608 NA 0.73 11.46 0.53 7.42e-26 Aortic root size; LUSC trans rs1941687 0.800 rs12968906 chr18:31378307 G/A cg27147174 chr7:100797783 AP1S1 -0.47 -6.92 -0.35 2.3e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs8072100 0.875 rs4794047 chr17:45763005 A/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.34 5.67 0.3 3.12e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7589728 1.000 rs7589728 chr2:88518440 G/A cg04511125 chr2:88470314 THNSL2 0.68 6.42 0.33 4.76e-10 Plasma clusterin levels; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.33 0.56 4.75e-29 Prudent dietary pattern; LUSC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.61 6.83 0.35 4.12e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504073 0.584 rs11776843 chr8:49928449 C/T cg00325661 chr8:49890786 NA 0.69 11.03 0.52 2.58e-24 Blood metabolite ratios; LUSC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg03526776 chr6:41159608 TREML2 0.33 6.26 0.32 1.2e-9 Alzheimer's disease (late onset); LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg04518342 chr5:131593106 PDLIM4 -0.45 -7.53 -0.38 4.66e-13 Breast cancer; LUSC cis rs2742234 0.955 rs2503849 chr10:43672776 G/A cg15436174 chr10:43711423 RASGEF1A -0.36 -6.34 -0.33 7.48e-10 Hirschsprung disease; LUSC cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg15839431 chr19:19639596 YJEFN3 -0.67 -7.36 -0.37 1.44e-12 Bipolar disorder; LUSC trans rs35110281 0.807 rs9984002 chr21:45061501 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 12.24 0.56 1.06e-28 Mean corpuscular volume; LUSC cis rs10740039 0.883 rs7898504 chr10:62417991 T/A cg18175470 chr10:62150864 ANK3 -0.46 -6.95 -0.36 1.97e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs17685 0.712 rs6976236 chr7:75741087 G/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.01 -0.4 1.99e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg24450063 chr1:156163899 SLC25A44 1.19 30.8 0.86 1.26e-99 Testicular germ cell tumor; LUSC cis rs9309473 0.948 rs10183818 chr2:73714556 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -7.1 -0.36 7.47e-12 Metabolite levels; LUSC cis rs17685 0.753 rs2286830 chr7:75693963 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.78 0.39 9.12e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg17971929 chr21:40555470 PSMG1 0.76 12.41 0.56 2.37e-29 Cognitive function; LUSC cis rs72799341 1.000 rs1458201 chr16:30916129 G/A cg02466173 chr16:30829666 NA -0.53 -7.99 -0.4 2.28e-14 Diastolic blood pressure; LUSC cis rs2762353 0.562 rs1165206 chr6:25867566 G/A cg12310025 chr6:25882481 NA -0.42 -7.11 -0.36 7.24e-12 Blood metabolite levels; LUSC cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg05340658 chr4:99064831 C4orf37 0.6 10.2 0.49 1.85e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg09359103 chr1:154839909 KCNN3 -0.7 -16.24 -0.66 4.09e-44 Prostate cancer; LUSC cis rs1062746 0.683 rs891094 chr16:87378001 C/G cg02258303 chr16:87377426 FBXO31 0.57 9.32 0.45 1.62e-18 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg12072164 chr19:44306565 LYPD5 0.3 6.27 0.32 1.09e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs7246967 0.551 rs34907478 chr19:22928831 T/C cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg08975724 chr8:8085496 FLJ10661 0.48 7.02 0.36 1.21e-11 Mood instability; LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg13560548 chr3:10150139 C3orf24 0.48 6.71 0.34 8.2e-11 Alzheimer's disease; LUSC cis rs3744061 0.530 rs2079778 chr17:74647097 C/T cg27546012 chr17:74684504 MXRA7 -0.35 -6.0 -0.31 5.16e-9 Retinal arteriolar caliber; LUSC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00934597 chr7:893267 UNC84A -0.45 -6.63 -0.34 1.35e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg16745616 chr19:8428856 ANGPTL4 -0.4 -6.03 -0.31 4.41e-9 HDL cholesterol; LUSC trans rs731565 0.737 rs6948030 chr7:147394199 C/T cg12847240 chr6:10382088 NA -0.54 -6.3 -0.33 9.21e-10 Diabetic kidney disease; LUSC cis rs5769707 0.681 rs739236 chr22:50041602 A/G cg05373962 chr22:49881684 NA -0.4 -8.29 -0.41 2.85e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1371867 0.810 rs3020182 chr8:101233008 T/C cg06002616 chr8:101225028 SPAG1 0.47 7.69 0.39 1.7e-13 Atrioventricular conduction; LUSC cis rs8017423 0.900 rs11625870 chr14:90693396 C/T cg14092571 chr14:90743983 NA 0.36 5.89 0.31 9.62e-9 Mortality in heart failure; LUSC cis rs17604090 0.536 rs112165062 chr7:29687592 C/T cg19413766 chr7:29689036 LOC646762 -0.58 -6.93 -0.35 2.12e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs6546550 0.901 rs7419837 chr2:70146625 T/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg18681998 chr4:17616180 MED28 -0.83 -14.35 -0.62 9.86e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs911119 0.913 rs34792920 chr20:23581876 C/T cg16589663 chr20:23618590 CST3 0.65 7.73 0.39 1.29e-13 Chronic kidney disease; LUSC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg19622623 chr12:86230825 RASSF9 -0.41 -5.69 -0.3 2.73e-8 Major depressive disorder; LUSC cis rs9486719 0.843 rs2499792 chr6:96846264 A/C cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs17270561 1.000 rs12211184 chr6:25823774 G/A cg17691542 chr6:26056736 HIST1H1C 0.76 9.88 0.48 2.38e-20 Iron status biomarkers; LUSC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg18099408 chr3:52552593 STAB1 -0.42 -7.38 -0.37 1.23e-12 Bipolar disorder; LUSC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg03806693 chr22:41940476 POLR3H -1.06 -15.24 -0.64 3.65e-40 Vitiligo; LUSC cis rs13217239 0.646 rs4269366 chr6:27016413 C/T cg12292205 chr6:26970375 C6orf41 0.5 8.3 0.41 2.6e-15 Schizophrenia; LUSC cis rs6456156 0.792 rs4710179 chr6:167513692 G/T cg07741184 chr6:167504864 NA 0.37 6.49 0.33 3.19e-10 Primary biliary cholangitis; LUSC cis rs868036 0.681 rs13329582 chr15:68104608 G/C cg05925327 chr15:68127851 NA -0.41 -6.46 -0.33 3.79e-10 Restless legs syndrome; LUSC cis rs12472274 0.646 rs34465035 chr2:239114093 C/A cg17459225 chr2:239074497 NA 0.57 7.86 0.4 5.33e-14 Phospholipid levels (plasma); LUSC cis rs12478296 0.792 rs6738361 chr2:243014257 C/T cg06360820 chr2:242988706 NA -0.91 -10.0 -0.48 8.84e-21 Obesity-related traits; LUSC trans rs76248362 0.748 rs943061 chr13:24431968 C/T cg08934785 chr7:27196759 HOXA7 -0.65 -6.97 -0.36 1.68e-11 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg07936489 chr17:37558343 FBXL20 0.7 9.8 0.47 4.14e-20 Glomerular filtration rate (creatinine); LUSC trans rs12579753 0.879 rs1922552 chr12:82158093 G/T cg07923666 chr12:49932857 KCNH3 -0.52 -6.75 -0.35 6.56e-11 Resting heart rate; LUSC cis rs6500395 1.000 rs1558816 chr16:48704868 T/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.87 -0.35 3.13e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg02038168 chr22:39784481 NA -0.41 -6.57 -0.34 1.99e-10 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg26384229 chr12:38710491 ALG10B 0.92 15.82 0.65 1.85e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.31 -0.33 8.87e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -8.91 -0.44 3.25e-17 Bipolar disorder and schizophrenia; LUSC cis rs11690935 0.550 rs55653103 chr2:172861816 T/C cg13550731 chr2:172543902 DYNC1I2 0.54 8.02 0.4 1.75e-14 Schizophrenia; LUSC cis rs6964587 1.000 rs7797369 chr7:91570615 C/A cg22117172 chr7:91764530 CYP51A1 -0.32 -5.82 -0.3 1.41e-8 Breast cancer; LUSC cis rs3818285 0.679 rs552419 chr10:111630883 G/T cg00817464 chr10:111662876 XPNPEP1 0.7 12.51 0.56 1.05e-29 Superior crus of antihelix expression; LUSC cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.29 -0.37 2.23e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg01652190 chr22:50026171 C22orf34 -0.31 -6.41 -0.33 5.03e-10 Monocyte count;Monocyte percentage of white cells; LUSC trans rs2727020 0.595 rs7924311 chr11:49507573 G/A cg03929089 chr4:120376271 NA -0.99 -17.63 -0.69 1.24e-49 Coronary artery disease; LUSC cis rs614226 0.938 rs7972244 chr12:120994872 A/G cg21053147 chr12:120880522 NA -0.48 -5.93 -0.31 7.41e-9 Type 1 diabetes nephropathy; LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.42 0.38 9.54e-13 Alzheimer's disease; LUSC trans rs61931739 0.500 rs11053251 chr12:34520743 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.09 0.45 9.21e-18 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg27170947 chr2:26402098 FAM59B 0.72 10.72 0.51 3.18e-23 Gut microbiome composition (summer); LUSC cis rs3782089 0.546 rs76146604 chr11:65277512 G/T cg00206168 chr11:65308501 LTBP3 1.26 8.19 0.41 5.76e-15 Height; LUSC cis rs8141529 1.000 rs132534 chr22:29299806 T/C cg15103426 chr22:29168792 CCDC117 -0.46 -5.66 -0.3 3.32e-8 Lymphocyte counts; LUSC cis rs17092148 0.887 rs6059915 chr20:33147737 C/G cg16810054 chr20:33298113 TP53INP2 -0.36 -5.79 -0.3 1.64e-8 Neuroticism; LUSC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs3741151 1.000 rs61037777 chr11:73046663 A/G cg17517138 chr11:73019481 ARHGEF17 0.91 8.52 0.42 5.7e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.03 0.4 1.69e-14 Parkinson's disease; LUSC cis rs4776059 1.000 rs11070907 chr15:52924231 G/T cg22715398 chr15:52968154 KIAA1370 -0.66 -9.48 -0.46 4.87e-19 Schizophrenia; LUSC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs62103177 0.564 rs11874805 chr18:77697110 T/C cg05926928 chr17:57297772 GDPD1 1.22 14.88 0.63 9.18e-39 Opioid sensitivity; LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg00149659 chr3:10157352 C3orf10 0.98 14.23 0.61 2.91e-36 Alzheimer's disease; LUSC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg12927641 chr6:109611667 NA -0.4 -6.92 -0.35 2.37e-11 Reticulocyte fraction of red cells; LUSC cis rs1994135 0.692 rs1816958 chr12:33695066 A/T cg06521331 chr12:34319734 NA -0.39 -5.83 -0.3 1.33e-8 Resting heart rate; LUSC cis rs859767 0.741 rs6729090 chr2:135401878 G/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.31 -0.33 9.04e-10 Neuroticism; LUSC trans rs7618501 0.635 rs7635002 chr3:49989155 T/G cg21659725 chr3:3221576 CRBN 0.63 10.4 0.49 3.79e-22 Intelligence (multi-trait analysis); LUSC cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg24692254 chr21:30365293 RNF160 0.79 12.99 0.58 1.66e-31 Selective IgA deficiency; LUSC cis rs61931739 0.500 rs7488438 chr12:34531359 G/T cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs7178572 0.568 rs12901739 chr15:77395491 C/T cg22256960 chr15:77711686 NA -0.5 -7.86 -0.4 5.17e-14 Type 2 diabetes; LUSC cis rs9653442 0.564 rs11687586 chr2:100789346 A/G cg07810366 chr2:100720526 AFF3 -0.43 -7.28 -0.37 2.43e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4285028 0.747 rs4048703 chr3:121374361 G/A cg11130432 chr3:121712080 ILDR1 -0.57 -8.17 -0.41 6.35e-15 Multiple sclerosis; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg11494091 chr17:61959527 GH2 0.64 13.66 0.6 4.76e-34 Prudent dietary pattern; LUSC cis rs3859192 0.561 rs12453343 chr17:38181176 C/A cg17467752 chr17:38218738 THRA -0.52 -7.44 -0.38 8.46e-13 White blood cell count; LUSC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg13770153 chr20:60521292 NA -0.64 -8.62 -0.43 2.74e-16 Body mass index; LUSC cis rs6545883 0.929 rs2593626 chr2:61665184 C/A cg15711740 chr2:61764176 XPO1 -0.46 -7.12 -0.36 6.47e-12 Tuberculosis; LUSC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg15790184 chr11:494944 RNH1 0.5 7.43 0.38 9.4e-13 Systemic lupus erythematosus; LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg05025164 chr4:1340916 KIAA1530 -0.65 -10.11 -0.48 3.82e-21 Obesity-related traits; LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg17968037 chr7:100024898 ZCWPW1 -0.44 -6.31 -0.33 8.82e-10 Platelet count; LUSC cis rs7917772 0.582 rs6584512 chr10:104329685 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.72 8.69 0.43 1.63e-16 Lung function (FEV1/FVC); LUSC cis rs1185460 0.967 rs1184902 chr11:118945337 A/G cg01677386 chr11:118938358 VPS11 -0.49 -7.01 -0.36 1.29e-11 Coronary artery disease; LUSC cis rs523522 0.962 rs655530 chr12:121022275 T/C cg12219531 chr12:120966889 COQ5 0.66 9.11 0.45 7.8e-18 High light scatter reticulocyte count; LUSC cis rs727505 0.866 rs56216989 chr7:124729068 T/A cg23710748 chr7:124431027 NA -0.4 -6.96 -0.36 1.79e-11 Lewy body disease; LUSC cis rs2694528 0.686 rs6864253 chr5:59862743 A/G cg11474532 chr5:59995715 DEPDC1B 0.81 6.43 0.33 4.46e-10 Parkinson's disease; LUSC cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg26384229 chr12:38710491 ALG10B -0.82 -14.07 -0.61 1.23e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg21535247 chr6:8435926 SLC35B3 0.58 8.97 0.44 2.22e-17 Motion sickness; LUSC cis rs7809950 0.817 rs58052742 chr7:107210003 A/G cg23024343 chr7:107201750 COG5 0.67 9.64 0.47 1.45e-19 Coronary artery disease; LUSC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg23985595 chr17:80112537 CCDC57 0.31 5.88 0.31 9.82e-9 Life satisfaction; LUSC trans rs6076960 0.652 rs3852946 chr20:6255311 C/T cg17788362 chr6:86352627 SYNCRIP 0.45 6.92 0.35 2.26e-11 Smooth-surface caries; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.21 -0.37 3.84e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg24675056 chr1:15929824 NA 0.48 8.27 0.41 3.15e-15 Systolic blood pressure; LUSC cis rs7759001 0.857 rs980961 chr6:27361019 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.77e-8 Glomerular filtration rate (creatinine); LUSC cis rs2219968 0.828 rs28764193 chr8:78942561 T/G cg00738934 chr8:78996279 NA -0.4 -7.22 -0.37 3.56e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs259282 0.605 rs60968670 chr19:33108982 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.65 9.65 0.47 1.39e-19 Schizophrenia; LUSC cis rs56104184 0.775 rs17272707 chr19:49404535 T/G cg21252483 chr19:49399788 TULP2 -0.48 -6.75 -0.35 6.68e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs77633900 0.614 rs2468113 chr15:76851421 G/C cg21673338 chr15:77095150 SCAPER -0.8 -7.32 -0.37 1.87e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs56283067 0.578 rs10948233 chr6:45364096 A/T cg20913747 chr6:44695427 NA 0.45 6.74 0.35 7.01e-11 Total body bone mineral density; LUSC cis rs9925964 0.869 rs749670 chr16:31088625 A/G cg02466173 chr16:30829666 NA 0.35 6.34 0.33 7.61e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg06064525 chr11:970664 AP2A2 -0.47 -10.41 -0.49 3.77e-22 Alzheimer's disease (late onset); LUSC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.25 0.45 2.85e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.88 0.31 9.91e-9 Intelligence (multi-trait analysis); LUSC cis rs1267303 0.642 rs2404611 chr1:46997127 C/G cg25110126 chr1:46999211 NA 0.73 9.98 0.48 1.09e-20 Monobrow; LUSC cis rs2197308 0.626 rs6581156 chr12:37858731 C/A cg26384229 chr12:38710491 ALG10B -0.83 -14.0 -0.61 2.35e-35 Morning vs. evening chronotype; LUSC cis rs1775715 0.870 rs1615256 chr10:32254101 T/C cg26784012 chr10:32216390 ARHGAP12 0.4 6.45 0.33 3.85e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11229555 0.645 rs34530191 chr11:58200854 A/G cg15696309 chr11:58395628 NA -0.67 -8.13 -0.41 8.64e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg08999081 chr20:33150536 PIGU 0.37 6.69 0.34 9.38e-11 Height; LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg21782813 chr7:2030301 MAD1L1 0.52 8.97 0.44 2.23e-17 Bipolar disorder and schizophrenia; LUSC trans rs853679 0.517 rs9348793 chr6:28084189 G/A cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg13298116 chr11:62369859 EML3;MTA2 0.59 9.64 0.47 1.43e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2729354 0.768 rs1001956 chr11:57266949 C/G cg24343310 chr11:57249947 NA 0.43 8.14 0.41 7.72e-15 Blood protein levels; LUSC cis rs6918586 0.658 rs198819 chr6:26124430 C/T cg17691542 chr6:26056736 HIST1H1C 0.39 5.88 0.31 9.77e-9 Schizophrenia; LUSC cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg21573476 chr21:45109991 RRP1B -0.4 -6.41 -0.33 4.97e-10 Mean corpuscular volume; LUSC cis rs1014246 0.778 rs12256473 chr10:118478448 G/A cg14919929 chr10:118506882 NA 0.45 6.67 0.34 1.07e-10 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs7786808 0.586 rs7794256 chr7:158206214 T/G cg02030672 chr11:45687055 CHST1 -0.39 -6.06 -0.31 3.73e-9 Obesity-related traits; LUSC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg15744005 chr10:104629667 AS3MT -0.28 -6.05 -0.31 3.84e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg07716408 chr11:68623521 NA -0.33 -6.44 -0.33 4.23e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -10.38 -0.49 4.77e-22 Platelet count; LUSC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11890956 chr21:40555474 PSMG1 -0.71 -11.09 -0.52 1.47e-24 Menarche (age at onset); LUSC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.47e-24 Aortic root size; LUSC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.706 rs763128 chr22:50018045 G/A cg20744362 chr22:50050164 C22orf34 0.39 7.33 0.37 1.75e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1577917 0.958 rs2084294 chr6:86565943 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.86 -0.44 4.78e-17 Response to antipsychotic treatment; LUSC cis rs5167 0.677 rs2238682 chr19:45458593 C/T cg25746394 chr19:45450501 APOC2 0.32 5.95 0.31 6.75e-9 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01797567 chr14:50087093 MGAT2;RPL36AL -0.43 -6.08 -0.32 3.29e-9 Electrocardiographic conduction measures; LUSC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.87 -0.4 5.04e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs12681287 0.640 rs13258126 chr8:87453378 G/T cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg11494091 chr17:61959527 GH2 0.65 13.92 0.61 4.91e-35 Prudent dietary pattern; LUSC cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg01689657 chr7:91764605 CYP51A1 0.33 6.03 0.31 4.29e-9 Breast cancer; LUSC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg07424592 chr7:64974309 NA 0.64 5.75 0.3 2e-8 Diabetic kidney disease; LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7107174 1.000 rs1318241 chr11:77930792 C/T cg02023728 chr11:77925099 USP35 0.52 7.26 0.37 2.76e-12 Testicular germ cell tumor; LUSC cis rs11779988 0.545 rs409217 chr8:17816597 C/G cg01800426 chr8:17659068 MTUS1 -0.5 -6.29 -0.33 9.96e-10 Breast cancer; LUSC cis rs12908161 1.000 rs35960805 chr15:85343980 T/G cg17507749 chr15:85114479 UBE2QP1 0.53 6.54 0.34 2.25e-10 Schizophrenia; LUSC cis rs6580649 0.941 rs4760683 chr12:48516296 T/C cg24011408 chr12:48396354 COL2A1 -0.48 -6.45 -0.33 4.01e-10 Lung cancer; LUSC cis rs2692947 0.763 rs7570074 chr2:96407037 T/C cg22654517 chr2:96458247 NA 0.37 7.48 0.38 6.63e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg09323728 chr8:95962352 TP53INP1 -0.29 -5.69 -0.3 2.72e-8 Type 2 diabetes; LUSC trans rs877282 0.898 rs11253344 chr10:765162 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC cis rs7851660 0.809 rs3808893 chr9:100663745 C/T cg13688889 chr9:100608707 NA -0.54 -8.42 -0.42 1.11e-15 Strep throat; LUSC cis rs6599077 0.950 rs11706046 chr3:40104137 T/C cg13683864 chr3:40499215 RPL14 -0.61 -7.6 -0.38 3.09e-13 Sleep-related phenotypes; LUSC cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg12292205 chr6:26970375 C6orf41 -0.51 -8.5 -0.42 6.34e-16 Schizophrenia; LUSC cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg24812749 chr6:127587940 RNF146 0.92 13.96 0.61 3.32e-35 Breast cancer; LUSC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg04398451 chr17:18023971 MYO15A -0.49 -7.99 -0.4 2.29e-14 Total body bone mineral density; LUSC cis rs847577 0.630 rs11764933 chr7:97825188 G/A cg21770322 chr7:97807741 LMTK2 0.56 10.08 0.48 4.99e-21 Breast cancer; LUSC cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg09537434 chr19:41945824 ATP5SL 0.68 10.12 0.48 3.58e-21 Migraine;Coronary artery disease; LUSC cis rs11229555 0.874 rs11605683 chr11:58350794 T/A cg15696309 chr11:58395628 NA -0.71 -9.19 -0.45 4.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg03264133 chr6:25882463 NA -0.48 -8.01 -0.4 1.98e-14 Intelligence (multi-trait analysis); LUSC cis rs17401966 0.522 rs946504 chr1:10308597 T/C cg19773385 chr1:10388646 KIF1B -0.37 -6.46 -0.33 3.77e-10 Hepatocellular carcinoma; LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg07507251 chr3:52567010 NT5DC2 0.31 6.2 0.32 1.7e-9 Bipolar disorder; LUSC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg11752832 chr7:134001865 SLC35B4 0.55 8.66 0.43 2.09e-16 Mean platelet volume; LUSC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.52 0.78 5.83e-69 Height; LUSC cis rs7582720 1.000 rs116382857 chr2:203751932 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC trans rs61931739 0.534 rs1387789 chr12:34056304 C/A cg26384229 chr12:38710491 ALG10B 0.7 10.84 0.51 1.12e-23 Morning vs. evening chronotype; LUSC cis rs6901250 0.851 rs7740481 chr6:117149307 G/C cg12892004 chr6:117198278 RFX6 0.43 8.16 0.41 7.04e-15 C-reactive protein levels; LUSC cis rs3092073 0.819 rs3848715 chr20:44564682 G/A cg27529037 chr20:44575021 PCIF1 -0.34 -5.77 -0.3 1.8e-8 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg05313129 chr8:58192883 C8orf71 -0.51 -6.52 -0.34 2.59e-10 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.524 rs12362318 chr11:47682671 T/C cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.46e-10 Subjective well-being; LUSC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 7.19 0.37 4.41e-12 Hip circumference adjusted for BMI; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05377162 chr1:185286996 IVNS1ABP -0.44 -5.97 -0.31 6.14e-9 Hepatitis; LUSC cis rs62458065 0.850 rs7804998 chr7:32461197 T/C cg20159608 chr7:32802032 NA -0.64 -7.57 -0.38 3.72e-13 Metabolite levels (HVA/MHPG ratio); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08258788 chr8:109455865 TTC35 0.48 7.17 0.37 4.71e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs67539049 1.000 rs55764254 chr8:11294184 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.4 -6.13 -0.32 2.51e-9 Itch intensity from mosquito bite; LUSC trans rs7824557 0.564 rs2736304 chr8:11236964 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.45 -0.38 7.98e-13 Retinal vascular caliber; LUSC trans rs7178375 0.678 rs34678577 chr15:31177465 A/C cg04373760 chr16:53404718 NA 0.62 8.15 0.41 7.19e-15 Hypertriglyceridemia; LUSC trans rs61931739 0.500 rs11519123 chr12:34436478 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.35e-33 Morning vs. evening chronotype; LUSC cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -7.76 -0.39 1.01e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10276381 1.000 rs10260837 chr7:28181129 C/T cg23620719 chr7:28220237 JAZF1 0.57 6.23 0.32 1.44e-9 Crohn's disease; LUSC trans rs9944715 0.954 rs9807157 chr18:43817755 T/C cg01718231 chr17:29326311 RNF135 -0.54 -7.71 -0.39 1.45e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs6736093 1.000 rs10496439 chr2:112664631 C/G cg12686935 chr2:112915763 FBLN7 -0.36 -5.8 -0.3 1.56e-8 Coronary artery disease; LUSC cis rs3126085 0.935 rs4845421 chr1:152173259 G/T cg03465714 chr1:152285911 FLG -0.41 -5.78 -0.3 1.71e-8 Atopic dermatitis; LUSC cis rs1950626 0.833 rs12897114 chr14:101395140 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.41 7.29 0.37 2.2e-12 Pelvic organ prolapse (moderate/severe); LUSC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg08847533 chr14:75593920 NEK9 -0.86 -15.86 -0.66 1.32e-42 Height; LUSC cis rs9549367 0.789 rs2287253 chr13:113891075 G/A cg18105134 chr13:113819100 PROZ 0.61 8.8 0.43 7.6e-17 Platelet distribution width; LUSC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg17366294 chr4:99064904 C4orf37 0.54 9.49 0.46 4.38e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs10489202 0.608 rs7533646 chr1:168077593 A/C cg24449463 chr1:168025552 DCAF6 -0.64 -9.52 -0.46 3.62e-19 Schizophrenia; LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg13732083 chr21:47605072 C21orf56 -0.45 -6.7 -0.34 8.72e-11 Testicular germ cell tumor; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg16647868 chr5:131706066 SLC22A5 0.35 5.87 0.31 1.03e-8 Blood metabolite levels; LUSC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg00343986 chr7:65444356 GUSB 0.48 7.27 0.37 2.51e-12 Aortic root size; LUSC cis rs9303401 0.659 rs12948133 chr17:56673602 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.96 0.61 3.28e-35 Cognitive test performance; LUSC cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg23093090 chr10:104574429 C10orf26 -0.43 -7.79 -0.39 8.73e-14 Arsenic metabolism; LUSC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15320075 chr8:145703422 NA -0.66 -11.35 -0.53 1.8e-25 Age at first birth; LUSC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.67 -9.12 -0.45 7.28e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg08754478 chr10:133766260 PPP2R2D 0.63 8.18 0.41 5.85e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs208520 1.000 rs12189683 chr6:66977716 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.86 -0.54 2.5e-27 Exhaled nitric oxide output; LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg07507251 chr3:52567010 NT5DC2 0.33 6.53 0.34 2.5e-10 Bipolar disorder; LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.04 0.36 1.12e-11 Bipolar disorder; LUSC cis rs2463822 0.669 rs72919475 chr11:62042361 T/A cg06239285 chr11:62104954 ASRGL1 -0.65 -6.65 -0.34 1.19e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg04455712 chr21:45112962 RRP1B 0.44 8.39 0.42 1.42e-15 Mean corpuscular volume; LUSC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg06641503 chr3:48959341 ARIH2 -0.39 -5.88 -0.31 9.73e-9 Parkinson's disease; LUSC cis rs11971779 0.680 rs10229358 chr7:139052545 C/T cg23387468 chr7:139079360 LUC7L2 -0.42 -6.32 -0.33 8.29e-10 Diisocyanate-induced asthma; LUSC trans rs1728785 1.000 rs1182968 chr16:68573945 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.65 0.39 2.18e-13 Ulcerative colitis; LUSC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs3806843 1.000 rs3756342 chr5:140165624 G/A cg26395211 chr5:140044315 WDR55 -0.37 -5.78 -0.3 1.74e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg24642439 chr20:33292090 TP53INP2 -0.51 -7.77 -0.39 1.01e-13 Glomerular filtration rate (creatinine); LUSC cis rs2073300 0.609 rs8183135 chr20:23384284 C/T cg12062639 chr20:23401060 NAPB 0.94 8.24 0.41 3.94e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2857891 0.817 rs2638102 chr11:6968610 T/C cg14883916 chr11:6947541 ZNF215 0.45 5.87 0.31 1.03e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg13393036 chr8:95962371 TP53INP1 -0.44 -9.42 -0.46 7.64e-19 Type 2 diabetes; LUSC cis rs12042938 0.507 rs1765776 chr1:231731607 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.73 -11.92 -0.55 1.54e-27 Neuranatomic and neurocognitive phenotypes; LUSC cis rs9399401 0.667 rs6912639 chr6:142770548 T/C cg03128060 chr6:142623767 GPR126 0.53 9.12 0.45 6.95e-18 Chronic obstructive pulmonary disease; LUSC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg14440974 chr22:39074834 NA -0.36 -5.96 -0.31 6.56e-9 Menopause (age at onset); LUSC cis rs7011049 1.000 rs11985185 chr8:53834494 T/C cg26025543 chr8:53854495 NA 0.51 6.3 0.33 9.53e-10 Systolic blood pressure; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg16145915 chr7:1198662 ZFAND2A -0.72 -14.73 -0.63 3.3e-38 Longevity;Endometriosis; LUSC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg25025879 chr12:53359317 NA -0.55 -8.18 -0.41 5.96e-15 Cancer (pleiotropy); LUSC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg06627628 chr2:24431161 ITSN2 -0.6 -7.16 -0.36 5.19e-12 Lymphocyte counts; LUSC cis rs394563 0.591 rs237012 chr6:149729198 T/C cg03678062 chr6:149772716 ZC3H12D -0.3 -6.2 -0.32 1.7e-9 Dupuytren's disease; LUSC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg15704280 chr7:45808275 SEPT13 -0.87 -14.83 -0.63 1.35e-38 Height; LUSC cis rs78366141 0.536 rs78517451 chr4:89650437 C/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.95 7.09 0.36 7.79e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11583043 0.958 rs12746722 chr1:101464789 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.25 0.32 1.23e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg03452623 chr4:187889614 NA -0.87 -17.7 -0.7 6.24e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467773 0.549 rs9467805 chr6:26583366 C/T cg05738196 chr6:26577821 NA 0.82 15.43 0.65 6.47e-41 Intelligence (multi-trait analysis); LUSC cis rs710216 0.763 rs12029931 chr1:43456880 C/T cg03128534 chr1:43423976 SLC2A1 0.46 6.47 0.33 3.53e-10 Red cell distribution width; LUSC cis rs929596 0.517 rs3806592 chr2:234625936 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -8.82 -0.43 6.26e-17 Total bilirubin levels in HIV-1 infection; LUSC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.05 -0.36 1.06e-11 Blood metabolite levels; LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3960554 0.808 rs112372188 chr7:75723376 G/A cg17325771 chr7:75508891 RHBDD2 -0.41 -5.71 -0.3 2.49e-8 Eotaxin levels; LUSC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg06618935 chr21:46677482 NA -0.42 -8.33 -0.41 2.07e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs57046232 0.552 rs2009127 chr20:6341680 C/T cg17788362 chr6:86352627 SYNCRIP 0.43 6.09 0.32 3.05e-9 Colorectal cancer; LUSC cis rs4654899 1.000 rs7535895 chr1:21439239 T/A cg01072550 chr1:21505969 NA -0.53 -8.1 -0.41 1.06e-14 Superior frontal gyrus grey matter volume; LUSC trans rs979233 0.502 rs10053179 chr5:42109207 A/G cg07010552 chr17:7358735 CHRNB1 -0.41 -6.01 -0.31 4.86e-9 Systemic lupus erythematosus; LUSC cis rs7818345 0.967 rs13258090 chr8:19285726 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.37 -7.05 -0.36 1.01e-11 Language performance in older adults (adjusted for episodic memory); LUSC trans rs7829975 0.572 rs7005000 chr8:8796602 A/G cg21775007 chr8:11205619 TDH -0.42 -6.36 -0.33 6.56e-10 Mood instability; LUSC cis rs950027 0.549 rs9920634 chr15:45596546 G/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.88 -0.4 4.78e-14 Response to fenofibrate (adiponectin levels); LUSC cis rs9815354 0.767 rs73077375 chr3:41853058 C/T cg03022575 chr3:42003672 ULK4 0.85 8.74 0.43 1.19e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 5.82 0.3 1.35e-8 Rheumatoid arthritis; LUSC cis rs9311676 0.632 rs62258078 chr3:58363432 G/A cg26110898 chr3:58419937 PDHB 0.42 6.76 0.35 6.24e-11 Systemic lupus erythematosus; LUSC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg06481639 chr22:41940642 POLR3H -0.52 -6.33 -0.33 7.88e-10 Vitiligo; LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18404041 chr3:52824283 ITIH1 -0.56 -10.89 -0.51 8.03e-24 Bipolar disorder; LUSC cis rs7681440 0.838 rs1348224 chr4:90761946 G/A cg20003494 chr4:90757398 SNCA -0.33 -5.7 -0.3 2.6e-8 Dementia with Lewy bodies; LUSC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg10792982 chr14:105748885 BRF1 -0.47 -8.49 -0.42 7.01e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.13 17.23 0.69 4.9e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs11048434 0.736 rs4309200 chr12:9121856 A/C cg13575925 chr12:9217583 LOC144571 0.35 6.42 0.33 4.65e-10 Sjögren's syndrome; LUSC cis rs9937943 0.667 rs35126294 chr16:74651005 T/C cg01733217 chr16:74700730 RFWD3 0.65 7.16 0.36 5.23e-12 Neutrophil percentage of white cells; LUSC cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.05 0.44 1.21e-17 Motion sickness; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg05896524 chr21:47604654 C21orf56 -0.57 -8.9 -0.44 3.65e-17 Testicular germ cell tumor; LUSC cis rs4076764 0.846 rs10753616 chr1:163415855 G/T cg06092702 chr1:163392909 NA 0.36 6.14 0.32 2.35e-9 Motion sickness; LUSC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg05855489 chr10:104503620 C10orf26 0.62 8.22 0.41 4.66e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4237845 0.537 rs4237844 chr12:58267987 A/G cg02175503 chr12:58329896 NA -0.46 -6.57 -0.34 1.88e-10 Intelligence (multi-trait analysis); LUSC cis rs12681288 0.576 rs7002793 chr8:963467 T/C cg04851639 chr8:1020857 NA -0.39 -7.66 -0.39 2.01e-13 Schizophrenia; LUSC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg06544989 chr22:39130855 UNC84B 0.34 5.91 0.31 8.34e-9 Menopause (age at onset); LUSC cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg15556689 chr8:8085844 FLJ10661 0.57 9.33 0.45 1.5e-18 Mood instability; LUSC cis rs7129556 0.539 rs1945747 chr11:77277387 A/T cg12586386 chr11:77299805 AQP11 0.23 5.69 0.3 2.84e-8 Weight loss (gastric bypass surgery); LUSC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg26513180 chr16:89883248 FANCA 0.9 16.77 0.68 3.15e-46 Vitiligo; LUSC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg13683864 chr3:40499215 RPL14 0.93 15.78 0.65 2.7e-42 Renal cell carcinoma; LUSC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.3 0.33 9.55e-10 Mean platelet volume; LUSC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg11211951 chr8:145729740 GPT -0.6 -12.41 -0.56 2.39e-29 Age at first birth; LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18099408 chr3:52552593 STAB1 -0.41 -7.0 -0.36 1.41e-11 Bipolar disorder; LUSC trans rs941408 0.890 rs1640269 chr19:2793194 A/C cg22153745 chr1:153894579 GATAD2B -0.56 -8.32 -0.41 2.32e-15 Total cholesterol levels; LUSC cis rs7927592 0.956 rs2510384 chr11:68391837 C/A cg16797656 chr11:68205561 LRP5 0.35 5.84 0.3 1.23e-8 Total body bone mineral density; LUSC trans rs2018683 0.649 rs12536605 chr7:28970500 C/T cg19402173 chr7:128379420 CALU -0.47 -7.13 -0.36 6.22e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs9811920 0.515 rs792836 chr3:99476384 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.31 -5.85 -0.31 1.15e-8 Axial length; LUSC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg06637938 chr14:75390232 RPS6KL1 0.5 7.67 0.39 1.92e-13 Height; LUSC cis rs9611565 0.729 rs203319 chr22:41914593 C/T cg03806693 chr22:41940476 POLR3H -0.79 -11.37 -0.53 1.55e-25 Vitiligo; LUSC cis rs10986311 0.802 rs1330811 chr9:127117346 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.46 7.37 0.37 1.33e-12 Vitiligo; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg27535305 chr1:53392650 SCP2 -0.43 -8.69 -0.43 1.62e-16 Monocyte count; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg07677032 chr17:61819896 STRADA 0.52 8.71 0.43 1.45e-16 Prudent dietary pattern; LUSC cis rs7223966 1.000 rs2013288 chr17:61785904 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.14 0.36 5.8e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.11 16.38 0.67 1.12e-44 Gut microbiome composition (summer); LUSC cis rs1113500 0.836 rs1539553 chr1:108589998 C/T cg06207961 chr1:108661230 NA -0.33 -6.09 -0.32 3.07e-9 Growth-regulated protein alpha levels; LUSC trans rs1927790 0.643 rs927710 chr13:97004796 T/G cg03198741 chr6:1003969 LOC285768 -0.41 -6.22 -0.32 1.5e-9 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07111501 chr17:62207504 ERN1 -0.45 -6.71 -0.34 8.11e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3087591 0.887 rs2905875 chr17:29541339 A/T cg24425628 chr17:29625626 OMG;NF1 0.59 8.5 0.42 6.53e-16 Hip circumference; LUSC cis rs7917772 0.582 rs10786691 chr10:104364652 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.94 0.51 5.25e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17270561 0.553 rs9379784 chr6:25725506 A/G cg17691542 chr6:26056736 HIST1H1C 0.58 7.89 0.4 4.37e-14 Iron status biomarkers; LUSC cis rs34779708 0.931 rs66887762 chr10:35330577 C/T cg03585969 chr10:35415529 CREM 0.65 9.29 0.45 2.04e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9329289 0.550 rs11251294 chr10:2562328 C/T cg15501526 chr10:2543763 NA -0.59 -9.54 -0.46 3.16e-19 Age-related hearing impairment; LUSC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg09263875 chr16:632152 PIGQ 0.71 13.28 0.59 1.29e-32 Height; LUSC cis rs1506636 0.962 rs629474 chr7:123399684 C/T cg03229431 chr7:123269106 ASB15 0.65 10.7 0.51 3.66e-23 Plateletcrit;Platelet count; LUSC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg00129232 chr17:37814104 STARD3 -0.48 -7.09 -0.36 8.24e-12 Asthma; LUSC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.37 5.66 0.3 3.23e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg14440974 chr22:39074834 NA -0.36 -5.92 -0.31 7.79e-9 Menopause (age at onset); LUSC cis rs4423214 0.592 rs79634040 chr11:71230169 G/C cg05163923 chr11:71159392 DHCR7 -0.68 -7.02 -0.36 1.22e-11 Vitamin D levels; LUSC cis rs887829 0.507 rs10929301 chr2:234663649 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.6 -0.38 2.97e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs9815354 0.680 rs112310714 chr3:42024797 A/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC trans rs61931739 0.534 rs11053029 chr12:34131766 G/T cg26384229 chr12:38710491 ALG10B 0.72 11.42 0.53 9.87e-26 Morning vs. evening chronotype; LUSC cis rs2758596 0.850 rs2842879 chr1:156163695 G/T cg24450063 chr1:156163899 SLC25A44 1.03 8.59 0.43 3.31e-16 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs7937682 0.889 rs3017767 chr11:111508098 A/G cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC cis rs9467773 1.000 rs6910899 chr6:26524339 A/G cg11502198 chr6:26597334 ABT1 0.59 9.3 0.45 1.85e-18 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg08219700 chr8:58056026 NA 0.72 7.76 0.39 1.04e-13 Developmental language disorder (linguistic errors); LUSC cis rs2979489 0.891 rs17626867 chr8:30311177 G/T cg26383811 chr8:30366931 RBPMS -0.48 -7.6 -0.38 3.05e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs308403 0.509 rs13117125 chr4:123670824 T/C cg10495464 chr4:123653540 BBS12;LOC729338 0.93 16.46 0.67 5.22e-45 Blood protein levels; LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg00814883 chr7:100076585 TSC22D4 -0.73 -9.76 -0.47 5.88e-20 Platelet count; LUSC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.8 0.39 8.21e-14 Parkinson's disease; LUSC trans rs1005277 0.579 rs2983343 chr10:38383332 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.57 -0.46 2.51e-19 Extrinsic epigenetic age acceleration; LUSC cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg02527881 chr3:46936655 PTH1R 0.41 7.19 0.37 4.41e-12 Colorectal cancer; LUSC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg07701084 chr6:150067640 NUP43 0.57 8.84 0.44 5.51e-17 Lung cancer; LUSC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.81 0.3 1.42e-8 Menopause (age at onset); LUSC cis rs11098499 0.644 rs10012252 chr4:120559139 T/C cg24375607 chr4:120327624 NA 0.72 11.47 0.53 6.89e-26 Corneal astigmatism; LUSC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg06697600 chr4:7070879 GRPEL1 -0.36 -5.77 -0.3 1.85e-8 Monocyte percentage of white cells; LUSC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg03258749 chr1:151040405 MLLT11 -0.58 -7.42 -0.38 9.51e-13 Blood trace element (Cu levels); LUSC trans rs11098499 0.863 rs10030660 chr4:120436704 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.66 0.34 1.15e-10 Corneal astigmatism; LUSC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg20243544 chr17:37824526 PNMT 0.48 6.87 0.35 3.24e-11 Asthma; LUSC cis rs2573652 0.722 rs12914180 chr15:100544416 T/C cg00587665 chr15:100533223 ADAMTS17 -0.38 -6.77 -0.35 5.66e-11 Height; LUSC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg22467129 chr15:76604101 ETFA -0.44 -7.03 -0.36 1.16e-11 Blood metabolite levels; LUSC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg05535760 chr7:792225 HEATR2 -0.78 -7.77 -0.39 1e-13 Cerebrospinal P-tau181p levels; LUSC cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.34 0.33 7.65e-10 Lobe attachment (rater-scored or self-reported); LUSC trans rs6951245 0.935 rs79143504 chr7:1110212 A/G cg13565492 chr6:43139072 SRF -0.63 -6.63 -0.34 1.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.39 0.42 1.37e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1559088 1.000 rs1559088 chr19:33551061 C/T cg27124370 chr19:33622961 WDR88 0.5 6.31 0.33 9.08e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg22903657 chr4:1355424 KIAA1530 -0.35 -5.78 -0.3 1.76e-8 Obesity-related traits; LUSC cis rs1981331 1.000 rs75843712 chr21:47976115 A/G cg23283320 chr21:48055893 PRMT2 1.13 8.24 0.41 3.91e-15 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg16230307 chr14:35515116 FAM177A1 0.68 8.18 0.41 5.81e-15 Psoriasis; LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17464271 chr1:1447047 ATAD3A 0.53 5.99 0.31 5.51e-9 Intelligence (multi-trait analysis); LUSC cis rs7481584 0.624 rs693687 chr11:3052494 A/G cg05729581 chr11:3078854 CARS 0.39 5.74 0.3 2.11e-8 Calcium levels; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg14893161 chr1:205819251 PM20D1 0.91 17.86 0.7 1.54e-50 Menarche (age at onset); LUSC cis rs2274273 0.624 rs67386901 chr14:55757364 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.88 0.48 2.24e-20 Protein biomarker; LUSC cis rs2346177 0.806 rs56048837 chr2:46656647 G/C cg02822958 chr2:46747628 ATP6V1E2 0.39 6.7 0.34 8.76e-11 HDL cholesterol; LUSC cis rs3960554 0.808 rs78340819 chr7:75673833 C/G cg17325771 chr7:75508891 RHBDD2 -0.4 -5.74 -0.3 2.11e-8 Eotaxin levels; LUSC trans rs561341 0.882 rs504887 chr17:30322881 T/A cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.52e-13 Hip circumference adjusted for BMI; LUSC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08109568 chr15:31115862 NA -0.58 -8.12 -0.41 9.22e-15 Huntington's disease progression; LUSC cis rs1577917 0.958 rs4707236 chr6:86583967 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.22 -0.32 1.45e-9 Response to antipsychotic treatment; LUSC cis rs7188861 0.768 rs430966 chr16:11389482 C/T cg00044050 chr16:11439710 C16orf75 0.57 6.18 0.32 1.87e-9 HDL cholesterol; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg13685833 chr1:53393034 SCP2 -0.4 -6.02 -0.31 4.59e-9 Monocyte count; LUSC cis rs2262909 0.962 rs422344 chr19:22230956 C/G cg11619707 chr19:22235551 ZNF257 0.38 5.78 0.3 1.75e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs72960926 0.744 rs11752717 chr6:74954435 G/A cg03266952 chr6:74778945 NA -0.85 -7.14 -0.36 5.86e-12 Metabolite levels (MHPG); LUSC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg14668632 chr7:2872130 GNA12 0.49 7.66 0.39 1.97e-13 Height; LUSC cis rs2439831 0.867 rs2447211 chr15:43936351 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC trans rs975739 0.868 rs5351 chr13:78475313 C/T cg24007552 chr7:39989862 CDK13 -0.39 -6.53 -0.34 2.41e-10 Hair color; LUSC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg27286337 chr10:134555280 INPP5A 0.92 12.05 0.55 5.3e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4253772 0.678 rs1053332 chr22:46640179 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.48 6.43 0.33 4.45e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.43e-34 Diabetic kidney disease; LUSC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg06238570 chr21:40685208 BRWD1 -0.62 -10.39 -0.49 4.36e-22 Cognitive function; LUSC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg19812747 chr11:111475976 SIK2 -0.51 -7.4 -0.38 1.1e-12 Primary sclerosing cholangitis; LUSC cis rs6570726 0.935 rs386344 chr6:145855622 A/G cg05347473 chr6:146136440 FBXO30 0.42 7.22 0.37 3.47e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6840360 0.593 rs10033405 chr4:152474489 A/G cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs2639990 1.000 rs632157 chr18:72911548 G/A cg11568697 chr18:72916393 ZADH2 0.62 6.81 0.35 4.62e-11 Vascular endothelial growth factor levels; LUSC cis rs3007168 1.000 rs3007168 chr14:51608293 G/A cg23942311 chr14:51606299 NA 0.36 5.99 0.31 5.57e-9 Cancer; LUSC cis rs3741151 1.000 rs112840535 chr11:73066771 G/A cg17517138 chr11:73019481 ARHGEF17 1.09 9.0 0.44 1.69e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg06784218 chr1:46089804 CCDC17 0.47 9.27 0.45 2.42e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12594515 0.967 rs12595138 chr15:45986108 G/C cg19682013 chr15:45996608 NA 0.38 5.75 0.3 2.03e-8 Waist circumference;Weight; LUSC cis rs7959452 0.640 rs4761233 chr12:69722880 T/C cg20891283 chr12:69753455 YEATS4 0.66 10.48 0.5 2.09e-22 Blood protein levels; LUSC cis rs4595586 0.679 rs7312898 chr12:39346833 T/C cg26384229 chr12:38710491 ALG10B 0.43 5.95 0.31 6.75e-9 Morning vs. evening chronotype; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21426974 chr4:140005758 ELF2 -0.38 -6.13 -0.32 2.52e-9 Electrocardiographic conduction measures; LUSC cis rs193541 0.586 rs11241662 chr5:122181975 A/G cg19077854 chr5:122220652 SNX24 -0.37 -8.05 -0.4 1.46e-14 Glucose homeostasis traits; LUSC cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg26384229 chr12:38710491 ALG10B 0.6 9.35 0.46 1.28e-18 Heart rate; LUSC cis rs7000551 0.751 rs2461490 chr8:22370115 G/C cg12081754 chr8:22256438 SLC39A14 0.46 6.9 0.35 2.56e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg19622623 chr12:86230825 RASSF9 -0.44 -6.2 -0.32 1.64e-9 Major depressive disorder; LUSC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs709400 1.000 rs58133129 chr14:104104759 A/G cg24130564 chr14:104152367 KLC1 -0.53 -7.69 -0.39 1.71e-13 Body mass index; LUSC cis rs600231 0.706 rs3782091 chr11:65336483 G/T cg21890820 chr11:65308645 LTBP3 -0.6 -8.62 -0.43 2.72e-16 Bone mineral density; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg13560548 chr3:10150139 C3orf24 0.51 7.2 0.37 4.08e-12 Alzheimer's disease; LUSC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg22800045 chr5:56110881 MAP3K1 -0.42 -5.87 -0.31 1.06e-8 Coronary artery disease; LUSC cis rs2637266 0.729 rs1099883 chr10:78516158 G/T cg18941641 chr10:78392320 NA 0.4 7.23 0.37 3.3e-12 Pulmonary function; LUSC cis rs62400317 0.859 rs10456548 chr6:45219699 T/C cg18551225 chr6:44695536 NA -0.45 -7.47 -0.38 7.03e-13 Total body bone mineral density; LUSC cis rs7197653 0.586 rs55856208 chr16:68324210 A/T cg05110241 chr16:68378359 PRMT7 -0.73 -8.01 -0.4 1.95e-14 Magnesium levels; LUSC cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg16339924 chr4:17578868 LAP3 0.55 8.15 0.41 7.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg05785598 chr3:49045655 WDR6 0.33 5.89 0.31 9.26e-9 Parkinson's disease; LUSC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg20790798 chr5:1857306 NA -0.49 -8.36 -0.42 1.66e-15 Cardiovascular disease risk factors; LUSC cis rs56283067 0.740 rs111810959 chr6:44709460 C/A cg18551225 chr6:44695536 NA -0.49 -8.57 -0.42 3.95e-16 Total body bone mineral density; LUSC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg17264618 chr3:40429014 ENTPD3 0.35 7.24 0.37 3.04e-12 Renal cell carcinoma; LUSC cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg09594475 chr20:60884601 LAMA5 -0.43 -5.76 -0.3 1.96e-8 Colorectal cancer; LUSC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.15 -0.32 2.27e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC trans rs11165623 0.564 rs7525803 chr1:97000791 T/C cg10631902 chr5:14652156 NA -0.41 -6.06 -0.31 3.69e-9 Hip circumference;Waist circumference; LUSC cis rs6977660 0.714 rs17141884 chr7:19790280 A/G cg07541023 chr7:19748670 TWISTNB -0.65 -7.17 -0.37 4.77e-12 Thyroid stimulating hormone; LUSC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg02574844 chr11:5959923 NA -0.46 -6.42 -0.33 4.66e-10 DNA methylation (variation); LUSC cis rs62458065 0.850 rs7785659 chr7:32461015 C/T cg20159608 chr7:32802032 NA -0.64 -7.57 -0.38 3.72e-13 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.11 0.45 7.69e-18 Tonsillectomy; LUSC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg17294928 chr15:75287854 SCAMP5 -0.83 -11.27 -0.52 3.6e-25 Blood trace element (Zn levels); LUSC cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg08999081 chr20:33150536 PIGU -0.51 -10.37 -0.49 5.03e-22 Glomerular filtration rate (creatinine); LUSC cis rs7647973 0.626 rs62262722 chr3:49769419 G/C cg13072238 chr3:49761600 GMPPB 0.7 8.8 0.43 7.46e-17 Menarche (age at onset); LUSC cis rs4363385 0.747 rs2339491 chr1:152985322 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.87 -0.31 1.07e-8 Inflammatory skin disease; LUSC cis rs427394 1.000 rs427394 chr5:6745875 A/G cg25011763 chr5:6727354 POLS -0.34 -5.87 -0.31 1.02e-8 Menopause (age at onset); LUSC cis rs7804356 0.954 rs10227673 chr7:26865299 G/A cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg11941060 chr3:133502564 NA -0.53 -8.19 -0.41 5.61e-15 Iron status biomarkers; LUSC cis rs896543 0.702 rs6715324 chr2:237495510 C/T cg25295825 chr2:237489920 CXCR7 0.51 6.31 0.33 9.02e-10 Alcohol dependence (age at onset); LUSC cis rs4077515 0.577 rs3812584 chr9:139312719 C/T cg14019695 chr9:139328340 INPP5E -0.47 -9.12 -0.45 7.29e-18 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC trans rs11039798 0.614 rs2174703 chr11:48788242 G/A cg03929089 chr4:120376271 NA 0.71 6.74 0.35 7.11e-11 Axial length; LUSC cis rs7712401 0.691 rs62377436 chr5:122353702 C/G cg19077854 chr5:122220652 SNX24 -0.4 -8.56 -0.42 4.22e-16 Mean platelet volume; LUSC cis rs12190007 0.547 rs3006181 chr6:169809117 T/A cg15038512 chr6:170123185 PHF10 -0.38 -6.14 -0.32 2.34e-9 Obesity-related traits; LUSC cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg03264133 chr6:25882463 NA -0.52 -9.58 -0.46 2.38e-19 Blood metabolite levels; LUSC cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg05347473 chr6:146136440 FBXO30 0.48 7.99 0.4 2.23e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -6.77 -0.35 5.9e-11 Developmental language disorder (linguistic errors); LUSC cis rs701145 0.585 rs357480 chr3:153891182 A/G cg10247383 chr3:153839028 SGEF -0.61 -5.74 -0.3 2.09e-8 Coronary artery disease; LUSC cis rs644799 0.525 rs3016206 chr11:95536724 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.85 14.09 0.61 1.05e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg16797656 chr11:68205561 LRP5 0.38 6.23 0.32 1.4e-9 Total body bone mineral density; LUSC cis rs11098499 0.657 rs9996569 chr4:120299004 G/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs4930103 0.935 rs2071094 chr11:2021164 G/T cg06197492 chr11:2016605 H19 0.42 6.97 0.36 1.68e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs6693567 0.545 rs2012751 chr1:150438266 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.11 0.36 7.28e-12 Migraine; LUSC cis rs3771570 0.901 rs62190407 chr2:242405772 G/A cg21155796 chr2:242212141 HDLBP 0.51 6.13 0.32 2.43e-9 Prostate cancer; LUSC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg15369054 chr17:80825471 TBCD -0.42 -6.81 -0.35 4.42e-11 Breast cancer; LUSC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg17385448 chr1:15911702 AGMAT 0.37 6.29 0.33 9.81e-10 Systolic blood pressure; LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg16325326 chr1:53192061 ZYG11B 0.71 11.6 0.54 2.19e-26 Monocyte count; LUSC cis rs17292804 0.506 rs71417868 chr14:104046592 A/T cg04998671 chr14:104000505 TRMT61A -0.47 -6.87 -0.35 3.1e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg03433033 chr1:76189801 ACADM 0.8 12.86 0.58 5.1e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10752881 1.000 rs12126434 chr1:182988414 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.68 -10.54 -0.5 1.25e-22 Colorectal cancer; LUSC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg25258033 chr6:167368657 RNASET2 0.45 7.1 0.36 7.58e-12 Crohn's disease; LUSC cis rs354225 0.544 rs4616509 chr2:54807982 T/C cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg10802521 chr3:52805072 NEK4 -0.47 -7.36 -0.37 1.43e-12 Bipolar disorder; LUSC trans rs8072100 0.967 rs4239162 chr17:45755810 G/A cg03886242 chr7:26192032 NFE2L3 -0.38 -6.26 -0.32 1.15e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12999616 0.948 rs35958372 chr2:98330858 T/C cg26665480 chr2:98280029 ACTR1B 0.65 6.91 0.35 2.44e-11 Colorectal cancer; LUSC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg08847533 chr14:75593920 NEK9 -0.8 -13.57 -0.6 9.99e-34 Height; LUSC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg10792982 chr14:105748885 BRF1 0.51 9.51 0.46 3.91e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs73198271 1.000 rs55971558 chr8:8614403 G/T cg01851573 chr8:8652454 MFHAS1 0.59 8.55 0.42 4.37e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2463822 0.748 rs2513053 chr11:62109473 T/A cg06239285 chr11:62104954 ASRGL1 0.98 10.97 0.51 4.05e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs16910800 0.689 rs4491218 chr11:23163977 G/A cg20040320 chr11:23191996 NA -0.61 -7.64 -0.39 2.32e-13 Cancer; LUSC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg26380479 chr7:97908229 NA -0.28 -6.27 -0.32 1.12e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs34734847 0.750 rs3829290 chr12:121126438 T/C cg21892295 chr12:121157589 UNC119B -0.36 -6.31 -0.33 9.04e-10 Mean corpuscular volume; LUSC cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg17063962 chr7:91808500 NA 0.6 9.42 0.46 7.55e-19 Breast cancer; LUSC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg09517075 chr8:22133004 PIWIL2 0.43 8.54 0.42 4.77e-16 Hypertriglyceridemia; LUSC trans rs16848425 1.000 rs58319662 chr4:73524244 A/G cg15289899 chr11:2397255 CD81 0.67 5.95 0.31 6.78e-9 Height; LUSC cis rs9300255 0.510 rs1790086 chr12:123672518 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.31 -0.33 8.81e-10 Neutrophil percentage of white cells; LUSC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg11632617 chr15:75315747 PPCDC -0.52 -6.68 -0.34 9.84e-11 Blood trace element (Zn levels); LUSC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg03188948 chr7:1209495 NA 0.59 6.9 0.35 2.67e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12464483 0.591 rs67686878 chr2:30895044 C/T cg17749961 chr2:30669863 LCLAT1 0.71 8.14 0.41 8.03e-15 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg11062466 chr8:58055876 NA 0.55 7.36 0.37 1.41e-12 Developmental language disorder (linguistic errors); LUSC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg18904891 chr8:8559673 CLDN23 0.6 8.13 0.41 8.64e-15 Obesity-related traits; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.58 9.66 0.47 1.29e-19 Lymphocyte counts; LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.29 0.67 2.45e-44 Gut microbiome composition (summer); LUSC cis rs12477438 0.765 rs7591992 chr2:99668954 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg09796270 chr17:17721594 SREBF1 0.42 7.43 0.38 9.16e-13 Total body bone mineral density; LUSC cis rs1003719 0.628 rs2252402 chr21:38520720 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.54 8.18 0.41 5.81e-15 Eye color traits; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg23034840 chr1:205782522 SLC41A1 0.56 7.78 0.39 9.23e-14 Menarche (age at onset); LUSC cis rs10089 1.000 rs10463838 chr5:127518305 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.83 0.54 3.25e-27 Ileal carcinoids; LUSC cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg18681998 chr4:17616180 MED28 0.78 13.54 0.6 1.34e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg00945038 chr17:61921165 SMARCD2 0.54 9.3 0.45 1.95e-18 Prudent dietary pattern; LUSC cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg23711669 chr6:146136114 FBXO30 0.87 16.23 0.66 4.29e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs7584330 0.704 rs11884395 chr2:238359366 C/T cg16989719 chr2:238392110 NA -0.41 -6.86 -0.35 3.42e-11 Prostate cancer; LUSC cis rs6545883 0.931 rs11125885 chr2:61755728 G/C cg15711740 chr2:61764176 XPO1 -0.5 -7.85 -0.39 5.9e-14 Tuberculosis; LUSC cis rs7208859 0.623 rs11657369 chr17:29136468 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg11764359 chr7:65958608 NA 0.55 7.23 0.37 3.32e-12 Aortic root size; LUSC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg14664628 chr15:75095509 CSK -0.55 -8.03 -0.4 1.66e-14 Breast cancer; LUSC cis rs7020830 0.858 rs1492714 chr9:37141259 T/C cg14294708 chr9:37120828 ZCCHC7 1.11 25.95 0.82 4.49e-82 Schizophrenia; LUSC cis rs7267979 0.966 rs2500433 chr20:25296335 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.51 -0.34 2.68e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11764590 0.715 rs55770986 chr7:2087823 T/C cg10840412 chr1:235813424 GNG4 0.51 6.18 0.32 1.87e-9 Neuroticism; LUSC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg13628971 chr7:2884303 GNA12 0.46 6.81 0.35 4.48e-11 Height; LUSC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg17279839 chr7:150038598 RARRES2 0.42 6.51 0.34 2.71e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs17604090 0.938 rs10241566 chr7:29690179 T/C cg19413766 chr7:29689036 LOC646762 -0.6 -7.26 -0.37 2.77e-12 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs12410462 0.581 rs112572966 chr1:227553905 C/T cg23173402 chr1:227635558 NA 0.54 6.37 0.33 6.19e-10 Major depressive disorder; LUSC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg06850241 chr22:41845214 NA 0.31 5.74 0.3 2.17e-8 Vitiligo; LUSC cis rs9388451 0.807 rs1268070 chr6:126041164 A/G cg05901451 chr6:126070800 HEY2 -0.88 -16.31 -0.67 2.12e-44 Brugada syndrome; LUSC cis rs4891159 0.505 rs680253 chr18:74167427 A/C cg24786174 chr18:74118243 ZNF516 -0.87 -17.07 -0.68 2.07e-47 Longevity; LUSC cis rs1957429 0.808 rs6573581 chr14:65331955 G/A cg23373153 chr14:65346875 NA 0.95 10.83 0.51 1.25e-23 Pediatric areal bone mineral density (radius); LUSC cis rs9581857 0.547 rs1235848 chr13:28111559 G/T cg22138327 chr13:27999177 GTF3A -0.53 -6.09 -0.32 3.1e-9 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs12579753 1.000 rs17692461 chr12:82171755 C/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.1 -0.32 2.86e-9 Resting heart rate; LUSC cis rs977987 0.585 rs62059845 chr16:75430713 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.77 -0.35 5.88e-11 Dupuytren's disease; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28785552 0.800 rs10853855 chr19:53232293 A/G cg10871876 chr19:53194124 ZNF83 0.55 8.46 0.42 8.24e-16 Response to paliperidone in schizophrenia (PANSS score); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20930060 chr6:163835395 QKI -0.42 -6.13 -0.32 2.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg22431228 chr1:16359049 CLCNKA -0.47 -9.53 -0.46 3.27e-19 Dilated cardiomyopathy; LUSC cis rs968567 0.528 rs174582 chr11:61607168 A/G cg21709803 chr11:61594965 FADS2 -0.39 -5.68 -0.3 2.89e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs4478037 0.643 rs9875798 chr3:33120448 G/C cg19404215 chr3:33155277 CRTAP 0.99 9.67 0.47 1.17e-19 Major depressive disorder; LUSC cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 8.25 0.41 3.64e-15 Colorectal cancer; LUSC cis rs1775715 0.737 rs2799000 chr10:32124894 C/T cg03015672 chr10:32216066 ARHGAP12 0.33 5.84 0.3 1.22e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs992157 0.710 rs7569907 chr2:219070551 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.49 7.69 0.39 1.71e-13 Colorectal cancer; LUSC cis rs8017423 0.647 rs12587362 chr14:90821227 G/T cg04374321 chr14:90722782 PSMC1 -0.44 -6.54 -0.34 2.26e-10 Mortality in heart failure; LUSC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg05084668 chr3:125655381 ALG1L -0.5 -6.98 -0.36 1.58e-11 Blood pressure (smoking interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25739137 chr3:183851986 EIF2B5 -0.48 -6.01 -0.31 4.97e-9 Bipolar disorder and schizophrenia; LUSC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg17830980 chr10:43048298 ZNF37B -0.47 -7.04 -0.36 1.07e-11 Breast cancer; LUSC trans rs629535 0.773 rs489206 chr8:70064883 T/C cg21567404 chr3:27674614 NA 0.97 15.32 0.64 1.75e-40 Dupuytren's disease; LUSC trans rs208520 0.526 rs4710310 chr6:66802808 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.22 -25.53 -0.81 1.79e-80 Exhaled nitric oxide output; LUSC cis rs344364 0.602 rs2437744 chr16:1908451 C/T cg00564555 chr16:1970112 NA 0.38 6.45 0.33 3.84e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs6456156 0.528 rs6936261 chr6:167469676 A/C cg06454157 chr6:167490870 NA -0.27 -6.65 -0.34 1.22e-10 Primary biliary cholangitis; LUSC cis rs3733418 0.929 rs12507869 chr4:165895674 T/C cg25904183 chr4:165877875 C4orf39;TRIM61 -0.46 -6.13 -0.32 2.42e-9 Obesity-related traits; LUSC cis rs7618501 1.000 rs9855505 chr3:49792158 T/G cg13072238 chr3:49761600 GMPPB -0.4 -6.52 -0.34 2.6e-10 Intelligence (multi-trait analysis); LUSC cis rs11690935 0.959 rs6754817 chr2:172663394 C/T cg13550731 chr2:172543902 DYNC1I2 -0.82 -13.45 -0.59 2.98e-33 Schizophrenia; LUSC cis rs965469 1.000 rs2236087 chr20:3255905 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -6.13 -0.32 2.44e-9 IFN-related cytopenia; LUSC cis rs10823500 0.748 rs12355080 chr10:71963608 G/A cg02100629 chr10:71892760 AIFM2 -0.38 -6.07 -0.32 3.45e-9 Blood protein levels; LUSC cis rs478304 0.637 rs11227255 chr11:65454044 C/T cg05805236 chr11:65401703 PCNXL3 -0.63 -10.33 -0.49 6.71e-22 Acne (severe); LUSC cis rs9814567 1.000 rs11706117 chr3:134212526 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.26 -0.59 1.54e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs17102423 0.594 rs2781374 chr14:65568563 C/T cg11161011 chr14:65562177 MAX -0.71 -10.82 -0.51 1.37e-23 Obesity-related traits; LUSC cis rs11018904 0.636 rs61903695 chr11:89922417 A/G cg26834418 chr11:89957033 CHORDC1 -0.46 -6.08 -0.32 3.36e-9 Intelligence (multi-trait analysis); LUSC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg24879335 chr3:133465180 TF 0.45 7.74 0.39 1.21e-13 Iron status biomarkers (transferrin levels); LUSC cis rs9300255 0.510 rs1790133 chr12:123698518 T/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.03 -0.31 4.36e-9 Neutrophil percentage of white cells; LUSC cis rs6577655 0.517 rs62525562 chr8:135587076 C/T cg17885191 chr8:135476712 NA 0.58 7.57 0.38 3.62e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs877282 0.891 rs12767062 chr10:797961 C/T cg13775593 chr10:823151 NA 0.3 5.7 0.3 2.61e-8 Uric acid levels; LUSC trans rs9401746 0.564 rs658429 chr6:124803536 C/T cg16857858 chr7:27213984 HOXA10 -0.53 -5.99 -0.31 5.4e-9 Bone mineral density (Ward's triangle area); LUSC cis rs61931739 0.534 rs11053016 chr12:34104372 C/T cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs9815354 0.812 rs35263917 chr3:41952852 T/C cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg01884057 chr2:25150051 NA 0.48 10.99 0.52 3.41e-24 Body mass index; LUSC cis rs790123 0.692 rs790129 chr3:122385170 C/T cg00926285 chr3:122398533 PARP14 0.38 5.71 0.3 2.5e-8 Response to angiotensin II receptor blocker therapy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22585957 chr12:8234808 NECAP1 0.47 7.01 0.36 1.31e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg09658497 chr7:2847517 GNA12 -0.35 -6.17 -0.32 2e-9 Height; LUSC cis rs9341835 0.772 rs9294197 chr6:64135648 A/G cg03326410 chr6:64151739 NA -0.37 -6.16 -0.32 2.09e-9 Schizophrenia; LUSC cis rs765787 0.530 rs16941017 chr15:45543281 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.67 -0.43 1.84e-16 Uric acid levels; LUSC cis rs6901250 0.851 rs339362 chr6:117165370 A/C cg12892004 chr6:117198278 RFX6 -0.45 -8.52 -0.42 5.53e-16 C-reactive protein levels; LUSC cis rs10392 0.543 rs4300896 chr20:37580130 A/C cg27552599 chr20:37590471 DHX35 0.43 6.99 0.36 1.53e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs11779988 0.543 rs410445 chr8:17882304 C/T cg01800426 chr8:17659068 MTUS1 -0.52 -6.41 -0.33 5.06e-10 Breast cancer; LUSC cis rs7590368 0.926 rs12621237 chr2:10957538 T/C cg15705551 chr2:10952987 PDIA6 0.53 7.38 0.37 1.25e-12 Educational attainment (years of education); LUSC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg23791538 chr6:167370224 RNASET2 -0.37 -5.74 -0.3 2.1e-8 Crohn's disease; LUSC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg21770322 chr7:97807741 LMTK2 0.42 7.35 0.37 1.52e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs11997175 0.574 rs9642707 chr8:33645789 C/G ch.8.33884649F chr8:33765107 NA 0.52 8.52 0.42 5.73e-16 Body mass index; LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg22638593 chr5:131593259 PDLIM4 0.49 7.48 0.38 6.76e-13 Acylcarnitine levels; LUSC trans rs4650994 0.524 rs2476558 chr1:178580953 C/T cg05059571 chr16:84539110 KIAA1609 0.46 8.86 0.44 4.98e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg13010199 chr12:38710504 ALG10B 0.7 10.81 0.51 1.44e-23 Bladder cancer; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -8.48 -0.42 7.45e-16 Longevity;Endometriosis; LUSC cis rs28647808 0.881 rs7029256 chr9:136263655 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs79387448 0.745 rs72995652 chr2:103171651 C/A cg09003973 chr2:102972529 NA 0.89 8.64 0.43 2.37e-16 Gut microbiota (bacterial taxa); LUSC cis rs10791323 0.569 rs546381 chr11:133760651 T/G cg00579200 chr11:133705235 NA -0.4 -6.02 -0.31 4.57e-9 Childhood ear infection; LUSC cis rs4595586 0.545 rs7976609 chr12:39394317 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs7291412 1.000 rs7291412 chr22:46459132 G/T cg09693106 chr22:46449821 C22orf26;LOC150381 0.39 6.38 0.33 5.94e-10 Dupuytren's disease;Subjective well-being; LUSC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg01368799 chr11:117014884 PAFAH1B2 0.52 6.86 0.35 3.39e-11 Blood protein levels; LUSC cis rs6845621 0.600 rs35850168 chr4:18913277 T/A cg12196642 chr4:18937545 NA -0.34 -6.3 -0.33 9.55e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.64 0.34 1.28e-10 Obesity-related traits; LUSC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.76 -0.43 1.02e-16 Lung cancer; LUSC cis rs9467711 0.591 rs10484435 chr6:26031811 A/C cg08501292 chr6:25962987 TRIM38 0.62 5.72 0.3 2.36e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2637266 0.685 rs2395427 chr10:78462535 G/A cg18941641 chr10:78392320 NA 0.34 5.8 0.3 1.51e-8 Pulmonary function; LUSC cis rs10193935 0.901 rs222464 chr2:42643889 C/T cg27598129 chr2:42591480 NA -0.61 -8.21 -0.41 4.76e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg13206674 chr6:150067644 NUP43 0.63 10.28 0.49 1.02e-21 Lung cancer; LUSC cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg13256891 chr4:100009986 ADH5 0.48 7.11 0.36 7.05e-12 Alcohol dependence; LUSC cis rs11098499 0.909 rs7681978 chr4:120383775 T/C cg24375607 chr4:120327624 NA 0.79 11.69 0.54 1.03e-26 Corneal astigmatism; LUSC cis rs5758659 1.000 rs5758677 chr22:42643039 A/C cg15557168 chr22:42548783 NA -0.43 -7.27 -0.37 2.62e-12 Cognitive function; LUSC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg09085632 chr11:111637200 PPP2R1B -1.09 -17.63 -0.69 1.17e-49 Primary sclerosing cholangitis; LUSC cis rs4589502 1.000 rs12440279 chr15:67133339 G/A cg09911534 chr15:67153556 NA -0.69 -7.45 -0.38 7.98e-13 Lung cancer (smoking interaction); LUSC cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg08807101 chr21:30365312 RNF160 -0.66 -10.28 -0.49 1.05e-21 Pancreatic cancer; LUSC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg04518342 chr5:131593106 PDLIM4 0.4 7.13 0.36 6.38e-12 Breast cancer; LUSC cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg19628046 chr18:33552617 C18orf21 -0.54 -6.5 -0.33 2.97e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs1451375 0.741 rs55738142 chr7:50632326 T/C cg18232548 chr7:50535776 DDC 0.52 8.07 0.4 1.32e-14 Malaria; LUSC cis rs6723226 0.961 rs13010404 chr2:32848854 T/G cg02381751 chr2:32503542 YIPF4 -0.57 -8.44 -0.42 9.44e-16 Intelligence (multi-trait analysis); LUSC cis rs1124376 1.000 rs9819628 chr3:20140837 A/G cg05072819 chr3:20081367 KAT2B -0.66 -7.68 -0.39 1.76e-13 Bipolar disorder and schizophrenia; LUSC cis rs3741151 0.773 rs73544783 chr11:73221256 C/G cg17517138 chr11:73019481 ARHGEF17 0.96 8.13 0.41 8.27e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9814567 0.896 rs1357764 chr3:134344928 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 13.84 0.6 9.53e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg27535305 chr1:53392650 SCP2 -0.49 -9.6 -0.47 1.96e-19 Monocyte count; LUSC cis rs722599 0.748 rs2537824 chr14:75367349 T/C cg08847533 chr14:75593920 NEK9 -0.48 -6.99 -0.36 1.51e-11 IgG glycosylation; LUSC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg20135002 chr11:47629003 NA -0.52 -8.08 -0.4 1.17e-14 Subjective well-being; LUSC cis rs10876993 0.928 rs7136269 chr12:58075937 G/A cg18357645 chr12:58087776 OS9 0.55 8.29 0.41 2.87e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs7106204 1.000 rs7931691 chr11:24221123 C/A ch.11.24196551F chr11:24239977 NA 0.99 9.97 0.48 1.12e-20 Response to Homoharringtonine (cytotoxicity); LUSC trans rs16918636 0.704 rs2356863 chr11:29127095 C/G cg01414886 chr20:62551784 DNAJC5 -0.42 -5.99 -0.31 5.44e-9 Menarche (age at onset); LUSC cis rs7089973 0.604 rs11196939 chr10:116593175 A/G cg03647239 chr10:116582469 FAM160B1 -0.42 -6.55 -0.34 2.12e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs629535 0.814 rs558511 chr8:70069908 C/A cg21567404 chr3:27674614 NA 0.98 15.66 0.65 7.7e-42 Dupuytren's disease; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg24675658 chr1:53192096 ZYG11B 0.57 8.92 0.44 3.22e-17 Monocyte count; LUSC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg23283495 chr1:209979779 IRF6 0.51 8.21 0.41 5.02e-15 Monobrow; LUSC cis rs6120849 0.707 rs6088694 chr20:33652371 G/A cg24642439 chr20:33292090 TP53INP2 0.58 6.5 0.34 2.87e-10 Protein C levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27649522 chr12:12877729 APOLD1 0.43 6.27 0.32 1.13e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.63 0.65 1.03e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs459571 0.959 rs461462 chr9:136911272 C/T cg14462750 chr9:136913113 BRD3 0.37 5.68 0.3 2.92e-8 Platelet distribution width; LUSC cis rs1451375 0.583 rs3807556 chr7:50610536 G/A cg18232548 chr7:50535776 DDC 0.55 7.48 0.38 6.45e-13 Malaria; LUSC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg12560992 chr17:57184187 TRIM37 0.83 15.03 0.64 2.42e-39 Intelligence (multi-trait analysis); LUSC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18404041 chr3:52824283 ITIH1 0.52 10.01 0.48 8.37e-21 Electroencephalogram traits; LUSC cis rs425277 0.565 rs61775448 chr1:2045376 A/G cg04315214 chr1:2043799 PRKCZ 0.47 9.93 0.48 1.51e-20 Height; LUSC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg04539111 chr16:67997858 SLC12A4 -0.46 -6.19 -0.32 1.8e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg26384229 chr12:38710491 ALG10B 0.63 10.04 0.48 6.9299999999999992e-21 Morning vs. evening chronotype; LUSC cis rs9467773 0.869 rs1796521 chr6:26421392 T/C cg09904177 chr6:26538194 HMGN4 -0.65 -10.57 -0.5 1.01e-22 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg10360323 chr17:41437877 NA 0.46 5.91 0.31 8.44e-9 Menopause (age at onset); LUSC cis rs6424115 0.800 rs2229583 chr1:24200983 C/T cg10978503 chr1:24200527 CNR2 0.54 13.12 0.58 5.28e-32 Immature fraction of reticulocytes; LUSC cis rs7572644 1.000 rs7572644 chr2:28320033 C/T cg27432699 chr2:27873401 GPN1 -0.48 -5.83 -0.3 1.33e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs10979 1.000 rs9373394 chr6:143890776 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs7223966 1.000 rs56057198 chr17:61733332 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.71 0.34 8.22e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs561341 0.739 rs7213369 chr17:30211878 G/A cg13647721 chr17:30228624 UTP6 -0.68 -7.96 -0.4 2.8e-14 Hip circumference adjusted for BMI; LUSC cis rs28595532 0.748 rs66615663 chr4:119336701 C/T cg21605333 chr4:119757512 SEC24D 0.95 7.97 0.4 2.59e-14 Cannabis dependence symptom count; LUSC cis rs6500602 0.702 rs17761816 chr16:4548832 C/G cg08645402 chr16:4508243 NA 0.51 8.67 0.43 1.91e-16 Schizophrenia; LUSC trans rs3960554 0.932 rs76873475 chr7:75829199 C/A cg19862616 chr7:65841803 NCRNA00174 0.88 9.98 0.48 1.04e-20 Eotaxin levels; LUSC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg09849774 chr21:43526787 UMODL1;C21orf128 -0.54 -8.15 -0.41 7.27e-15 IgG glycosylation; LUSC cis rs734999 0.588 rs2260976 chr1:2527678 A/G cg18854424 chr1:2615690 NA -0.49 -9.67 -0.47 1.15e-19 Ulcerative colitis; LUSC cis rs6460942 0.730 rs73053536 chr7:12323131 C/G cg06484146 chr7:12443880 VWDE -0.64 -5.83 -0.3 1.3e-8 Coronary artery disease; LUSC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg12564285 chr5:131593104 PDLIM4 0.44 8.0 0.4 2.08e-14 Breast cancer; LUSC cis rs7177699 0.581 rs7181432 chr15:79123779 C/T cg15571903 chr15:79123663 NA 0.34 6.32 0.33 8.21e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -5.67 -0.3 3.05e-8 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg07362569 chr17:61921086 SMARCD2 0.37 7.67 0.39 1.92e-13 Prudent dietary pattern; LUSC cis rs11098499 0.954 rs35091806 chr4:120325529 G/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs11190604 1.000 rs7080356 chr10:102266735 A/C cg16342193 chr10:102329863 NA -0.32 -5.94 -0.31 7.16e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg21782813 chr7:2030301 MAD1L1 0.47 7.93 0.4 3.39e-14 Bipolar disorder and schizophrenia; LUSC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg01657329 chr11:68192670 LRP5 -0.45 -7.18 -0.37 4.64e-12 Total body bone mineral density; LUSC cis rs877282 0.945 rs10904555 chr10:787740 C/A cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs7246657 0.943 rs4802766 chr19:37981933 T/C cg23950597 chr19:37808831 NA -0.62 -7.37 -0.37 1.31e-12 Coronary artery calcification; LUSC cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg26597838 chr10:835615 NA -0.47 -6.4 -0.33 5.37e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs6456156 0.586 rs720325 chr6:167467349 G/T cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.42e-8 Primary biliary cholangitis; LUSC cis rs472402 0.580 rs3736316 chr5:6656210 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.46 -6.68 -0.34 9.79e-11 Response to amphetamines; LUSC cis rs826838 0.586 rs10785554 chr12:38628749 T/A cg26384229 chr12:38710491 ALG10B 0.59 8.88 0.44 4.24e-17 Heart rate; LUSC cis rs231513 0.954 rs11654245 chr17:41992650 T/C cg26893861 chr17:41843967 DUSP3 0.55 5.82 0.3 1.36e-8 Cognitive function; LUSC cis rs4737010 0.501 rs2032736 chr8:41639266 C/A cg17182837 chr8:41585554 ANK1 0.4 6.87 0.35 3.23e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg13010199 chr12:38710504 ALG10B 0.57 8.64 0.43 2.29e-16 Bladder cancer; LUSC cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg13010199 chr12:38710504 ALG10B -0.58 -9.17 -0.45 4.85e-18 Bladder cancer; LUSC cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg16240275 chr20:61666158 NCRNA00029 0.42 8.89 0.44 3.82e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs7917772 0.505 rs61869211 chr10:104449836 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 8.43 0.42 1.05e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 6.97e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs72634258 0.554 rs4908699 chr1:7905274 G/A cg00042356 chr1:8021962 PARK7 0.52 5.67 0.3 3.1e-8 Inflammatory bowel disease; LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.78 0.47 5.13e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4664304 0.900 rs3828327 chr2:160742095 G/A cg03641300 chr2:160917029 PLA2R1 -0.39 -6.22 -0.32 1.46e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs2865776 chr4:97971736 C/T cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg09835421 chr16:68378352 PRMT7 -0.53 -6.11 -0.32 2.83e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9341808 0.718 rs9352803 chr6:80864667 G/T cg08355045 chr6:80787529 NA 0.56 9.59 0.46 2.07e-19 Sitting height ratio; LUSC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg09699651 chr6:150184138 LRP11 0.37 5.78 0.3 1.7e-8 Lung cancer; LUSC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg05373962 chr22:49881684 NA -0.44 -10.55 -0.5 1.24e-22 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg25072359 chr17:41440525 NA 0.59 8.37 0.42 1.62e-15 Menopause (age at onset); LUSC cis rs10934753 0.632 rs13070856 chr3:125909415 A/G cg01346077 chr3:125931526 NA -0.47 -8.9 -0.44 3.52e-17 Plasma homocysteine levels (post-methionine load test); LUSC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg05717871 chr11:638507 DRD4 -0.35 -6.1 -0.32 3.01e-9 Systemic lupus erythematosus; LUSC cis rs4285028 0.747 rs9808981 chr3:121429561 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.85 -0.58 5.58e-31 Multiple sclerosis; LUSC cis rs1030877 0.960 rs3792047 chr2:105901553 A/G cg02079111 chr2:105885981 TGFBRAP1 -0.74 -13.21 -0.59 2.32e-32 Obesity-related traits; LUSC cis rs1346 0.580 rs2298615 chr11:65352062 C/T cg17120908 chr11:65337727 SSSCA1 -0.44 -6.3 -0.33 9.23e-10 Vertical cup-disc ratio;Optic cup area; LUSC cis rs4363385 0.553 rs11580383 chr1:152942192 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -5.77 -0.3 1.77e-8 Inflammatory skin disease; LUSC cis rs988712 0.622 rs2030323 chr11:27728539 A/C cg10635145 chr11:27742435 BDNF 0.48 6.46 0.33 3.66e-10 Obesity; LUSC cis rs3736594 0.513 rs62138964 chr2:27814438 C/T cg27432699 chr2:27873401 GPN1 0.65 8.74 0.43 1.17e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg01191920 chr7:158217561 PTPRN2 -0.59 -12.05 -0.55 5.03e-28 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08243778 chr1:212458726 PPP2R5A 0.44 6.06 0.31 3.77e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10892173 0.566 rs10892174 chr11:117672565 A/C cg07621104 chr11:117668040 DSCAML1 0.49 6.41 0.33 4.91e-10 Myopia; LUSC cis rs12425451 0.544 rs28623776 chr12:3147631 C/T cg05389053 chr12:3131226 TEAD4 -0.44 -5.91 -0.31 8.45e-9 Narcolepsy with cataplexy; LUSC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.18e-11 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.967 rs6924865 chr6:26521353 A/G cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.11e-18 Intelligence (multi-trait analysis); LUSC cis rs524023 0.874 rs7105665 chr11:64396568 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.37 -0.49 4.89e-22 Urate levels in obese individuals; LUSC cis rs3862435 0.764 rs2589948 chr15:90952232 G/A cg22089800 chr15:90895588 ZNF774 0.58 6.32 0.33 8.53e-10 Response to exercise (triglyceride level interaction); LUSC cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.27 -0.37 2.57e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg16850897 chr7:100343110 ZAN 0.37 5.89 0.31 9.66e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs6998277 1.000 rs16869658 chr8:103633762 C/T cg10187029 chr8:103597600 NA 0.62 7.75 0.39 1.14e-13 Migraine; LUSC cis rs34779708 0.966 rs4934732 chr10:35431684 T/C cg03585969 chr10:35415529 CREM 0.6 9.01 0.44 1.64e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg05347473 chr6:146136440 FBXO30 0.55 9.23 0.45 3.28e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs8044995 0.706 rs73612697 chr16:68162016 G/A cg27539214 chr16:67997921 SLC12A4 -0.59 -7.21 -0.37 3.87e-12 Schizophrenia; LUSC cis rs3096299 0.802 rs3102336 chr16:89442006 C/T cg02187348 chr16:89574699 SPG7 0.51 7.52 0.38 4.97e-13 Multiple myeloma (IgH translocation); LUSC cis rs9283706 0.623 rs10055631 chr5:66305438 A/C cg11590213 chr5:66331682 MAST4 0.46 7.11 0.36 7.19e-12 Coronary artery disease; LUSC trans rs6502050 0.835 rs8077926 chr17:80117315 C/A cg07393940 chr7:158741817 NA 0.36 6.48 0.33 3.24e-10 Life satisfaction; LUSC cis rs11122272 0.735 rs2486727 chr1:231539245 A/G cg06096015 chr1:231504339 EGLN1 0.55 9.62 0.47 1.75e-19 Hemoglobin concentration; LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg13047869 chr3:10149882 C3orf24 -0.59 -8.41 -0.42 1.21e-15 Alzheimer's disease; LUSC cis rs713587 0.563 rs7591460 chr2:25103967 A/C cg15423357 chr2:25149977 NA 0.38 7.46 0.38 7.58e-13 Body mass index in non-asthmatics; LUSC cis rs11971779 0.680 rs7779900 chr7:139082987 G/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg18252515 chr7:66147081 NA -1.19 -12.9 -0.58 3.46e-31 Diabetic kidney disease; LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg08088566 chr11:430123 ANO9 0.59 6.84 0.35 3.72e-11 Body mass index; LUSC cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 5.82 0.3 1.36e-8 Schizophrenia; LUSC cis rs3858526 0.834 rs7113548 chr11:5989293 G/A cg02574844 chr11:5959923 NA -0.44 -6.11 -0.32 2.72e-9 DNA methylation (variation); LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg06600287 chr1:53387719 ECHDC2 -0.28 -5.73 -0.3 2.26e-8 Monocyte count; LUSC cis rs10744422 0.925 rs2292132 chr12:123332834 T/C cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.14e-12 Schizophrenia; LUSC cis rs4363385 0.626 rs12062847 chr1:153062994 A/G cg00922841 chr1:152955080 SPRR1A -0.34 -5.88 -0.31 1e-8 Inflammatory skin disease; LUSC trans rs11098499 0.618 rs28491261 chr4:120294900 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.05 0.31 3.85e-9 Corneal astigmatism; LUSC cis rs6089584 0.830 rs6089309 chr20:60585687 T/C cg23262073 chr20:60523788 NA -0.41 -6.02 -0.31 4.7e-9 Body mass index; LUSC cis rs2361710 0.704 rs4889979 chr17:78121707 T/A cg20811857 chr17:78079795 GAA -0.32 -5.95 -0.31 6.82e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs6977660 0.941 rs6953957 chr7:19820560 A/G cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs17818399 0.926 rs1378764 chr2:46839681 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.44 -5.85 -0.31 1.15e-8 Height; LUSC cis rs921968 0.528 rs13382651 chr2:219628191 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.35 -0.49 5.81e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs12928939 0.815 rs61753635 chr16:71660404 G/A cg03805757 chr16:71968109 PKD1L3 -0.4 -5.72 -0.3 2.35e-8 Post bronchodilator FEV1; LUSC cis rs6499188 0.571 rs1645975 chr16:68564448 C/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC trans rs61931739 0.517 rs1843735 chr12:34047389 C/G cg26384229 chr12:38710491 ALG10B 0.68 10.67 0.5 4.61e-23 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs2467864 chr15:45641098 C/T cg21132104 chr15:45694354 SPATA5L1 -0.57 -8.19 -0.41 5.58e-15 Homoarginine levels; LUSC cis rs2857891 0.817 rs1491829 chr11:6968941 T/A cg14883916 chr11:6947541 ZNF215 0.44 5.86 0.31 1.11e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.57 -8.43 -0.42 1.05e-15 Gut microbiome composition (summer); LUSC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg04369109 chr6:150039330 LATS1 -0.5 -7.2 -0.37 4.14e-12 Lung cancer; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg24642844 chr7:1081250 C7orf50 -0.8 -10.96 -0.51 4.5e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg09655341 chr17:79618100 PDE6G 0.27 6.31 0.33 9.05e-10 Eye color traits; LUSC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg12927641 chr6:109611667 NA -0.36 -6.12 -0.32 2.57e-9 Reticulocyte fraction of red cells; LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.24 0.37 3.2e-12 Gut microbiome composition (summer); LUSC cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.31 6.72 0.35 7.81e-11 Coronary artery disease; LUSC cis rs992157 0.697 rs13384682 chr2:219069137 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.49 7.69 0.39 1.7e-13 Colorectal cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06745235 chr1:180471494 ACBD6 0.45 6.76 0.35 6.08e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs2857891 0.650 rs2638087 chr11:6990516 C/T cg04053776 chr11:6947353 ZNF215 0.43 6.15 0.32 2.27e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg03264133 chr6:25882463 NA 0.38 6.29 0.33 9.97e-10 Intelligence (multi-trait analysis); LUSC cis rs829883 0.966 rs249853 chr12:98864908 A/C cg25150519 chr12:98850993 NA 0.53 7.6 0.38 2.99e-13 Colorectal adenoma (advanced); LUSC cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.86 -0.35 3.39e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs3806843 0.966 rs3756338 chr5:140180561 A/G cg25815440 chr2:42134162 NA -0.26 -6.02 -0.31 4.47e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs7107174 0.892 rs10899487 chr11:78085474 G/A cg02023728 chr11:77925099 USP35 0.45 6.6 0.34 1.6e-10 Testicular germ cell tumor; LUSC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg06582575 chr6:163149167 PACRG;PARK2 1.1 15.52 0.65 2.72e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs76878669 0.519 rs10791869 chr11:66117113 C/T cg18002602 chr11:66138449 SLC29A2 -0.48 -8.44 -0.42 9.66e-16 Educational attainment (years of education); LUSC trans rs8073060 0.586 rs225305 chr17:33921160 C/T cg19694781 chr19:47549865 TMEM160 -1.14 -18.05 -0.7 2.57e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.17e-9 Blood metabolite levels; LUSC cis rs12681287 0.888 rs13042 chr8:87484913 G/A cg27223183 chr8:87520930 FAM82B -0.49 -6.83 -0.35 3.91e-11 Caudate activity during reward; LUSC cis rs6580649 0.769 rs60629297 chr12:48438290 T/A cg24011408 chr12:48396354 COL2A1 -0.47 -6.22 -0.32 1.47e-9 Lung cancer; LUSC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg05855489 chr10:104503620 C10orf26 -0.63 -8.18 -0.41 5.81e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7100689 0.646 rs10749581 chr10:82141651 A/G cg01528321 chr10:82214614 TSPAN14 -0.87 -13.22 -0.59 2.19e-32 Post bronchodilator FEV1; LUSC cis rs11971779 0.680 rs6947215 chr7:139026638 A/G cg07862535 chr7:139043722 LUC7L2 0.52 7.17 0.37 4.75e-12 Diisocyanate-induced asthma; LUSC cis rs11676348 0.783 rs13035513 chr2:218960680 C/T cg00012203 chr2:219082015 ARPC2 -0.57 -9.14 -0.45 6.3e-18 Ulcerative colitis; LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg20607798 chr8:58055168 NA 0.51 5.67 0.3 3.06e-8 Developmental language disorder (linguistic errors); LUSC cis rs7584330 0.868 rs7571898 chr2:238383028 T/C cg16989719 chr2:238392110 NA -0.36 -5.9 -0.31 9.01e-9 Prostate cancer; LUSC cis rs9467711 0.560 rs6900665 chr6:26487169 C/T cg12826209 chr6:26865740 GUSBL1 0.66 5.78 0.3 1.72e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7193541 0.682 rs28681530 chr16:74682496 C/T cg01733217 chr16:74700730 RFWD3 0.97 22.15 0.77 1.61e-67 Multiple myeloma; LUSC cis rs7520050 0.966 rs2275426 chr1:46487552 G/A cg06784218 chr1:46089804 CCDC17 -0.29 -5.69 -0.3 2.83e-8 Red blood cell count;Reticulocyte count; LUSC cis rs9653442 0.593 rs4851273 chr2:100848321 A/G cg22139774 chr2:100720529 AFF3 -0.41 -6.72 -0.35 7.72e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9399401 0.922 rs9496369 chr6:142724918 C/T cg03128060 chr6:142623767 GPR126 0.33 6.0 0.31 5.15e-9 Chronic obstructive pulmonary disease; LUSC cis rs11098499 0.863 rs36040693 chr4:120477616 A/G cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg18538332 chr22:24372958 LOC391322 -0.46 -8.14 -0.41 8.15e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6701037 1.000 rs6677097 chr1:175123897 C/G cg00321850 chr1:175162397 KIAA0040 -0.38 -6.5 -0.33 2.98e-10 Alcohol dependence; LUSC cis rs7647973 0.848 rs4292260 chr3:49148890 T/C cg07636037 chr3:49044803 WDR6 0.96 11.89 0.55 1.93e-27 Menarche (age at onset); LUSC cis rs12579753 1.000 rs12811607 chr12:82233619 T/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg13736514 chr6:26305472 NA -0.49 -9.75 -0.47 6.16e-20 Educational attainment; LUSC cis rs734999 0.611 rs10797431 chr1:2501222 G/T cg18854424 chr1:2615690 NA 0.47 9.34 0.46 1.4e-18 Ulcerative colitis; LUSC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -8.44 -0.42 1.01e-15 Hemoglobin concentration; LUSC cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg16339924 chr4:17578868 LAP3 -0.44 -6.46 -0.33 3.69e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1153858 1.000 rs1288775 chr15:45661678 T/A cg14582100 chr15:45693742 SPATA5L1 0.57 10.28 0.49 1.04e-21 Homoarginine levels; LUSC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg14895029 chr7:2775587 GNA12 -0.37 -5.79 -0.3 1.62e-8 Height; LUSC cis rs459571 0.959 rs461462 chr9:136911272 C/T cg13789015 chr9:136890014 NCRNA00094 0.67 12.44 0.56 1.96e-29 Platelet distribution width; LUSC cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.21 29.12 0.85 1.14e-93 Chronic sinus infection; LUSC cis rs2204008 0.623 rs1663281 chr12:38120936 A/G cg13010199 chr12:38710504 ALG10B -0.53 -7.94 -0.4 3.11e-14 Bladder cancer; LUSC cis rs7914558 0.966 rs3977751 chr10:104920232 A/G cg04362960 chr10:104952993 NT5C2 0.58 9.49 0.46 4.46e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1728785 0.892 rs4783562 chr16:68562963 A/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.8 -0.3 1.52e-8 Ulcerative colitis; LUSC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.62 0.47 1.7e-19 Hip circumference adjusted for BMI; LUSC cis rs4474465 0.831 rs10899510 chr11:78170841 G/A cg27205649 chr11:78285834 NARS2 -0.49 -5.83 -0.3 1.3e-8 Alzheimer's disease (survival time); LUSC cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.03 0.55 6.29e-28 Motion sickness; LUSC cis rs9325144 0.560 rs6582561 chr12:38666821 G/A cg26384229 chr12:38710491 ALG10B -0.66 -10.27 -0.49 1.11e-21 Morning vs. evening chronotype; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg27384338 chr17:2031545 SMG6 -0.42 -6.98 -0.36 1.59e-11 N-glycan levels; LUSC cis rs6723226 0.804 rs17428810 chr2:32736043 T/C cg02381751 chr2:32503542 YIPF4 -0.67 -9.77 -0.47 5.3e-20 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 6.48 0.33 3.37e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9309473 1.000 rs13428235 chr2:73633430 G/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.83 -0.35 3.95e-11 Metabolite levels; LUSC cis rs6840360 0.642 rs2053566 chr4:152445831 A/C cg20465933 chr4:152376761 FAM160A1 0.33 5.97 0.31 6.02e-9 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg06238570 chr21:40685208 BRWD1 0.65 10.91 0.51 6.68e-24 Cognitive function; LUSC cis rs9715521 0.775 rs62301198 chr4:59848776 C/T cg11281224 chr4:60001000 NA -0.46 -6.47 -0.33 3.55e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1858037 0.867 rs55945621 chr2:65615354 G/A cg08085232 chr2:65598271 SPRED2 -0.42 -6.29 -0.33 9.78e-10 Rheumatoid arthritis; LUSC cis rs7246967 0.673 rs8103430 chr19:22931498 A/G cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg23649088 chr2:200775458 C2orf69 -0.54 -6.94 -0.36 2e-11 Schizophrenia; LUSC cis rs12908161 0.959 rs11637728 chr15:85203392 A/T cg12863693 chr15:85201151 NMB 0.43 8.74 0.43 1.12e-16 Schizophrenia; LUSC cis rs34779708 0.966 rs17500582 chr10:35498788 T/A cg04310649 chr10:35416472 CREM -0.41 -6.31 -0.33 8.89e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12594515 1.000 rs8039974 chr15:45986665 A/G cg01629716 chr15:45996671 NA 0.4 6.01 0.31 4.9e-9 Waist circumference;Weight; LUSC cis rs4363385 0.747 rs1577965 chr1:152968294 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.8 -0.39 8.1e-14 Inflammatory skin disease; LUSC cis rs6547741 1.000 rs2384654 chr2:27847364 C/T cg27432699 chr2:27873401 GPN1 0.81 15.35 0.64 1.26e-40 Oral cavity cancer; LUSC cis rs992157 1.000 rs736730 chr2:219120255 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.55 8.29 0.41 2.72e-15 Colorectal cancer; LUSC cis rs2921073 0.509 rs2976931 chr8:8257317 C/A cg11608241 chr8:8085544 FLJ10661 0.38 5.67 0.3 3.04e-8 Parkinson's disease; LUSC cis rs170557 0.573 rs2484034 chr1:210254787 A/G cg21951975 chr1:209979733 IRF6 0.41 5.87 0.31 1.04e-8 Alopecia areata; LUSC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.43 6.5 0.33 2.96e-10 Systemic lupus erythematosus; LUSC cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg09184832 chr6:79620586 NA -0.44 -7.04 -0.36 1.07e-11 Intelligence (multi-trait analysis); LUSC cis rs709400 0.628 rs1989565 chr14:103862193 G/A cg10523860 chr14:103875565 MARK3 0.4 6.47 0.33 3.44e-10 Body mass index; LUSC cis rs9814567 1.000 rs62271515 chr3:134300507 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6940638 0.688 rs9348750 chr6:27057945 T/G cg12826209 chr6:26865740 GUSBL1 0.55 8.07 0.4 1.26e-14 Intelligence (multi-trait analysis); LUSC cis rs10752881 1.000 rs12028740 chr1:182985581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg22823121 chr1:150693482 HORMAD1 0.61 9.49 0.46 4.64e-19 Tonsillectomy; LUSC cis rs12190007 0.508 rs6605539 chr6:169731997 A/T cg16388071 chr6:169726476 NA 0.38 6.18 0.32 1.87e-9 Obesity-related traits; LUSC cis rs9467711 0.560 rs6900665 chr6:26487169 C/T cg09904177 chr6:26538194 HMGN4 -0.74 -6.66 -0.34 1.1e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9467773 0.620 rs9461275 chr6:26590801 C/T cg11502198 chr6:26597334 ABT1 0.71 11.9 0.55 1.84e-27 Intelligence (multi-trait analysis); LUSC trans rs225245 0.791 rs4796103 chr17:34025182 A/G cg19694781 chr19:47549865 TMEM160 -0.39 -6.2 -0.32 1.66e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs2242116 0.932 rs4683301 chr3:46931478 A/T cg27129171 chr3:47204927 SETD2 -0.44 -6.43 -0.33 4.4e-10 Birth weight; LUSC cis rs5769707 0.732 rs135865 chr22:50004829 G/A cg10356904 chr22:49881777 NA -0.29 -5.86 -0.31 1.12e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9393692 0.967 rs6456712 chr6:26302573 A/C cg00631329 chr6:26305371 NA -0.49 -9.57 -0.46 2.41e-19 Educational attainment; LUSC cis rs981844 0.740 rs10024619 chr4:154684441 A/T cg14289246 chr4:154710475 SFRP2 -0.52 -7.43 -0.38 9.38e-13 Response to statins (LDL cholesterol change); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19566272 chr6:139695824 CITED2 0.46 6.24 0.32 1.34e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2279817 1.000 rs35148872 chr1:18020184 G/A cg21791023 chr1:18019539 ARHGEF10L -0.49 -6.72 -0.35 7.82e-11 Neuroticism; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg09033563 chr22:24373618 LOC391322 -0.54 -7.78 -0.39 9.32e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7586879 1.000 rs11683212 chr2:25120196 T/C cg01884057 chr2:25150051 NA 0.42 9.02 0.44 1.46e-17 Body mass index; LUSC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.887 rs717551 chr6:25855624 T/C cg17691542 chr6:26056736 HIST1H1C 0.79 9.74 0.47 6.83e-20 Iron status biomarkers; LUSC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg24110177 chr3:50126178 RBM5 -0.55 -8.92 -0.44 3.16e-17 Intelligence (multi-trait analysis); LUSC cis rs7180079 1.000 rs62024567 chr15:64494826 T/A cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs9905704 0.647 rs3809723 chr17:57061978 T/G cg12560992 chr17:57184187 TRIM37 0.62 9.93 0.48 1.62e-20 Testicular germ cell tumor; LUSC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.64 -9.55 -0.46 2.81e-19 Hip circumference adjusted for BMI; LUSC trans rs2243480 1.000 rs34560516 chr7:65404092 A/T cg10756647 chr7:56101905 PSPH 0.87 8.46 0.42 8.27e-16 Diabetic kidney disease; LUSC cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg08213375 chr14:104286397 PPP1R13B 0.52 10.17 0.49 2.35e-21 Schizophrenia; LUSC cis rs977987 0.843 rs6564260 chr16:75447426 A/G cg03315344 chr16:75512273 CHST6 0.48 8.92 0.44 3.16e-17 Dupuytren's disease; LUSC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg20608306 chr11:116969690 SIK3 0.37 6.33 0.33 7.85e-10 Blood protein levels; LUSC cis rs7474896 0.616 rs2474561 chr10:38373544 C/T cg25427524 chr10:38739819 LOC399744 -0.55 -7.23 -0.37 3.36e-12 Obesity (extreme); LUSC cis rs9326248 0.581 rs12804122 chr11:116902616 C/G cg26566898 chr11:117069891 TAGLN 0.34 6.46 0.33 3.77e-10 Blood protein levels; LUSC cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg10621924 chr7:39171070 POU6F2 0.44 6.53 0.34 2.51e-10 IgG glycosylation; LUSC cis rs11051970 0.704 rs2733694 chr12:32555230 A/G cg24626660 chr12:32551988 NA 0.31 5.72 0.3 2.39e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.52 0.5 1.55e-22 Schizophrenia; LUSC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg01616529 chr11:638424 DRD4 -0.32 -5.65 -0.3 3.4e-8 Systemic lupus erythematosus; LUSC cis rs6772849 0.930 rs7639400 chr3:128323356 T/C cg16766828 chr3:128327626 NA -0.31 -5.76 -0.3 1.89e-8 Monocyte percentage of white cells;Monocyte count; LUSC cis rs1559088 0.847 rs3760891 chr19:33599708 C/T cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.03e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7264396 0.790 rs10211771 chr20:34219994 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.72 -0.47 8.09e-20 Total cholesterol levels; LUSC cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.34 0.37 1.61e-12 Motion sickness; LUSC cis rs6690583 0.943 rs1837329 chr1:85469614 G/A cg11262906 chr1:85462892 MCOLN2 -0.7 -8.64 -0.43 2.28e-16 Serum sulfate level; LUSC trans rs11992162 0.560 rs13276386 chr8:11797421 T/A cg06636001 chr8:8085503 FLJ10661 0.46 6.38 0.33 5.76e-10 Monocyte count; LUSC cis rs11105298 0.891 rs10777162 chr12:89830523 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.18 -0.37 4.63e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg16339924 chr4:17578868 LAP3 0.55 8.37 0.42 1.57e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg12257692 chr3:49977190 RBM6 -0.25 -6.91 -0.35 2.48e-11 Body mass index; LUSC cis rs9747201 1.000 rs56283054 chr17:80135326 C/T cg18209359 chr17:80159595 CCDC57 0.38 6.52 0.34 2.65e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6674970 1.000 rs4970941 chr1:151068546 A/G cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.45 -6.05 -0.31 3.93e-9 Childhood ear infection; LUSC cis rs9341835 0.740 rs9294198 chr6:64136993 T/C cg00787780 chr6:64151745 NA -0.33 -5.77 -0.3 1.82e-8 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07184439 chr14:50087799 RPL36AL;MGAT2 0.5 6.86 0.35 3.35e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs300703 0.542 rs376385 chr2:190245 G/A cg21211680 chr2:198530 NA 0.56 6.76 0.35 6.18e-11 Blood protein levels; LUSC trans rs10882873 0.503 rs1253407 chr10:98969068 A/G cg03566752 chr6:35512600 NA -0.24 -5.97 -0.31 6.17e-9 Lymphocyte percentage of white cells; LUSC cis rs6700896 0.931 rs4655584 chr1:66155515 T/G cg04111102 chr1:66153794 NA 0.33 7.38 0.37 1.25e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg15605315 chr1:45957053 TESK2 0.51 8.49 0.42 6.93e-16 High light scatter reticulocyte count; LUSC cis rs6088580 0.524 rs7274854 chr20:33228672 A/C cg24642439 chr20:33292090 TP53INP2 0.53 8.39 0.42 1.41e-15 Glomerular filtration rate (creatinine); LUSC cis rs6736093 0.796 rs4848980 chr2:112816348 A/G cg12686935 chr2:112915763 FBLN7 -0.4 -6.47 -0.33 3.47e-10 Coronary artery disease; LUSC cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg27490568 chr2:178487706 NA -0.41 -6.07 -0.32 3.45e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg09367891 chr1:107599246 PRMT6 -0.54 -8.46 -0.42 8.55e-16 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.62e-13 Bipolar disorder; LUSC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.25 0.64 3.12e-40 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.735 rs1607015 chr15:76702429 C/T cg23625390 chr15:77176239 SCAPER -0.61 -9.39 -0.46 9.41e-19 Blood metabolite levels; LUSC cis rs8114671 0.935 rs6142313 chr20:33780427 A/G cg07148914 chr20:33460835 GGT7 -0.42 -6.32 -0.33 8.3e-10 Height; LUSC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg19774624 chr17:42201019 HDAC5 -0.8 -13.44 -0.59 3.23e-33 Total body bone mineral density; LUSC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.7 -8.69 -0.43 1.64e-16 Menarche (age at onset); LUSC cis rs7202877 0.610 rs3851735 chr16:75372092 A/G cg03315344 chr16:75512273 CHST6 0.4 5.7 0.3 2.7e-8 Type 2 diabetes;Type 1 diabetes; LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg13395646 chr4:1353034 KIAA1530 -0.59 -9.07 -0.44 1.08e-17 Obesity-related traits; LUSC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg02931644 chr1:25747376 RHCE 0.37 6.8 0.35 4.83e-11 Erythrocyte sedimentation rate; LUSC cis rs6754311 0.773 rs666407 chr2:136640233 A/G cg07169764 chr2:136633963 MCM6 0.56 7.49 0.38 6.24e-13 Mosquito bite size; LUSC cis rs6693567 0.565 rs7513182 chr1:150442612 A/G cg15654264 chr1:150340011 RPRD2 -0.44 -7.07 -0.36 8.88e-12 Migraine; LUSC cis rs1577917 0.610 rs11752795 chr6:86287129 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.48 7.46 0.38 7.67e-13 Response to antipsychotic treatment; LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.72 -0.39 1.35e-13 Lymphocyte counts; LUSC trans rs2262909 0.962 rs56369285 chr19:22267185 T/C cg17074339 chr11:11642133 GALNTL4 0.47 7.17 0.37 4.94e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg07061783 chr6:25882402 NA -0.38 -5.86 -0.31 1.12e-8 Blood metabolite levels; LUSC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC trans rs2898290 0.540 rs35005793 chr8:11450472 G/A cg08975724 chr8:8085496 FLJ10661 0.43 6.09 0.32 3.06e-9 Systolic blood pressure; LUSC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg13175981 chr1:150552382 MCL1 0.5 7.15 0.36 5.6e-12 Tonsillectomy; LUSC cis rs748404 0.631 rs1133395 chr15:43650384 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.29 0.33 1.01e-9 Lung cancer; LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.4 0.62 6.35e-37 Platelet count; LUSC cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs877282 0.891 rs12767043 chr10:797943 C/T cg13775593 chr10:823151 NA 0.3 5.7 0.3 2.61e-8 Uric acid levels; LUSC cis rs1372520 0.684 rs184810 chr4:90697979 T/C cg15133208 chr4:90757351 SNCA 0.55 8.14 0.41 8.08e-15 Neuroticism; LUSC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg19592336 chr6:28129416 ZNF389 0.48 6.3 0.33 9.46e-10 Depression; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg00814883 chr7:100076585 TSC22D4 -0.69 -9.31 -0.45 1.71e-18 Platelet count; LUSC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00504756 chr16:74330795 PSMD7 -0.46 -5.97 -0.31 6.18e-9 Bipolar disorder and schizophrenia; LUSC cis rs12216125 0.549 rs9358905 chr6:26077839 T/A cg17691542 chr6:26056736 HIST1H1C 0.53 8.08 0.4 1.17e-14 Iron status biomarkers; LUSC cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.47 6.96 0.36 1.81e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9747201 1.000 rs9303023 chr17:80175920 C/T cg07393940 chr7:158741817 NA 0.51 8.0 0.4 2.07e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg26384229 chr12:38710491 ALG10B 0.87 14.09 0.61 1.09e-35 Bladder cancer; LUSC cis rs1348850 0.914 rs4893938 chr2:178250095 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.4 0.42 1.28e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs17401966 0.522 rs10864450 chr1:10333959 G/T cg17425144 chr1:10567563 PEX14 -0.33 -5.96 -0.31 6.31e-9 Hepatocellular carcinoma; LUSC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg22823121 chr1:150693482 HORMAD1 0.61 9.33 0.45 1.48e-18 Urate levels; LUSC cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg04362960 chr10:104952993 NT5C2 0.59 8.98 0.44 2.07e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg26380479 chr7:97908229 NA -0.27 -5.95 -0.31 6.69e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg17042849 chr6:26104293 HIST1H4C -0.39 -5.74 -0.3 2.1e-8 Height; LUSC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg11663144 chr21:46675770 NA -0.4 -6.89 -0.35 2.74e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg17143192 chr8:8559678 CLDN23 0.59 8.54 0.42 4.85e-16 Obesity-related traits; LUSC cis rs7584330 0.554 rs2325838 chr2:238386515 C/A cg14458575 chr2:238380390 NA 0.68 8.33 0.41 2.15e-15 Prostate cancer; LUSC cis rs7215564 0.908 rs56078934 chr17:78658849 A/C cg23238734 chr17:78661607 RPTOR 0.48 6.16 0.32 2.07e-9 Myopia (pathological); LUSC cis rs868036 0.718 rs4776984 chr15:68118194 A/C cg24579218 chr15:68104479 NA -0.38 -6.68 -0.34 9.8e-11 Restless legs syndrome; LUSC trans rs3733585 0.631 rs7699671 chr4:10125874 C/T cg26043149 chr18:55253948 FECH -0.52 -7.36 -0.37 1.43e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs7119 0.717 rs12898656 chr15:77807995 C/T cg27398640 chr15:77910606 LINGO1 0.28 5.87 0.31 1.03e-8 Type 2 diabetes; LUSC cis rs4474465 0.850 rs10899551 chr11:78256998 A/C cg27205649 chr11:78285834 NARS2 -0.48 -5.73 -0.3 2.2e-8 Alzheimer's disease (survival time); LUSC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3540 0.574 rs2526000 chr15:90962626 C/T cg22089800 chr15:90895588 ZNF774 0.6 9.35 0.46 1.28e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10053149 chr1:28908509 SNHG12;SNORA44;SNORA16A 0.39 6.0 0.31 5.06e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22496380 chr5:211416 CCDC127 -0.85 -8.89 -0.44 3.85e-17 Breast cancer; LUSC cis rs478304 0.651 rs11227281 chr11:65496558 T/C cg10518572 chr11:65560635 OVOL1 -0.25 -5.75 -0.3 1.97e-8 Acne (severe); LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.29 0.37 2.23e-12 Alzheimer's disease; LUSC cis rs738322 0.775 rs4820324 chr22:38599857 G/C cg25457927 chr22:38595422 NA 0.48 10.04 0.48 6.43e-21 Cutaneous nevi; LUSC cis rs11098499 0.954 rs6849561 chr4:120409694 C/G cg09307838 chr4:120376055 NA -0.78 -11.04 -0.52 2.35e-24 Corneal astigmatism; LUSC cis rs7460090 0.620 rs13276221 chr8:57210878 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.34 0.37 1.63e-12 Height; LUSC cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg23625390 chr15:77176239 SCAPER 0.51 8.04 0.4 1.57e-14 Blood metabolite levels; LUSC cis rs11648796 0.757 rs66649828 chr16:766078 A/G cg07343612 chr16:622815 PIGQ -0.44 -5.91 -0.31 8.26e-9 Height; LUSC cis rs7572644 0.723 rs7578052 chr2:28318879 G/A cg27432699 chr2:27873401 GPN1 0.45 5.94 0.31 7e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs11098499 0.954 rs878373 chr4:120237484 A/T cg09307838 chr4:120376055 NA 0.81 12.04 0.55 5.49e-28 Corneal astigmatism; LUSC cis rs11792861 0.619 rs2289480 chr9:111705501 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.68 12.08 0.55 4.14e-28 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11947801 chr19:49016810 LMTK3 -0.4 -5.97 -0.31 6.1e-9 Electrocardiographic conduction measures; LUSC cis rs12474201 0.775 rs7584870 chr2:46973400 A/T cg06386533 chr2:46925753 SOCS5 0.64 9.79 0.47 4.71e-20 Height; LUSC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg00310523 chr12:86230176 RASSF9 0.51 9.63 0.47 1.52e-19 Major depressive disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20930514 chr14:77499758 NA 0.45 6.74 0.35 7.14e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13108904 0.870 rs2335855 chr4:1237968 T/C cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.88e-13 Obesity-related traits; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26169320 chr13:77901010 MYCBP2 -0.44 -6.02 -0.31 4.47e-9 Hepatitis; LUSC cis rs67696533 0.957 rs293566 chr20:31097877 T/C cg13636640 chr20:31349939 DNMT3B 0.41 5.98 0.31 5.67e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs7560272 0.501 rs11126417 chr2:73974315 A/G cg20560298 chr2:73613845 ALMS1 -0.38 -5.67 -0.3 3.02e-8 Schizophrenia; LUSC cis rs12541635 0.934 rs10955407 chr8:107020648 G/A cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.71e-20 Age of smoking initiation; LUSC cis rs1692580 0.682 rs12045693 chr1:2205581 A/C cg03732007 chr1:2071316 PRKCZ -0.36 -6.07 -0.32 3.48e-9 Coronary artery disease; LUSC trans rs4729127 1.000 rs9641132 chr7:94011381 G/T cg20086523 chr13:52378287 DHRS12 0.55 6.43 0.33 4.48e-10 Intelligence; LUSC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg22800045 chr5:56110881 MAP3K1 0.7 9.28 0.45 2.27e-18 Initial pursuit acceleration; LUSC cis rs7267979 0.714 rs1555329 chr20:25231858 G/A cg08601574 chr20:25228251 PYGB 0.48 7.44 0.38 8.75e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg18252515 chr7:66147081 NA -1.19 -12.9 -0.58 3.46e-31 Diabetic kidney disease; LUSC cis rs9807841 0.555 rs6511708 chr19:10788813 A/G cg17710535 chr19:10819994 QTRT1 0.4 6.34 0.33 7.34e-10 Inflammatory skin disease; LUSC trans rs7100689 0.622 rs2994389 chr10:82062257 C/G cg07663200 chr17:42030104 NA -0.37 -6.17 -0.32 1.99e-9 Post bronchodilator FEV1; LUSC trans rs61931739 0.500 rs11053268 chr12:34545121 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.57 7.32 0.37 1.83e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.15e-9 Blood metabolite levels; LUSC cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg27129171 chr3:47204927 SETD2 -0.69 -11.58 -0.54 2.66e-26 Colorectal cancer; LUSC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg20503657 chr10:835505 NA 0.78 9.74 0.47 6.96e-20 Eosinophil percentage of granulocytes; LUSC cis rs9325144 0.647 rs12830095 chr12:38864199 C/T cg26384229 chr12:38710491 ALG10B -0.6 -9.23 -0.45 3.26e-18 Morning vs. evening chronotype; LUSC trans rs11098499 0.754 rs10213554 chr4:120260785 A/G cg25214090 chr10:38739885 LOC399744 -0.41 -6.2 -0.32 1.62e-9 Corneal astigmatism; LUSC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -6.96 -0.36 1.82e-11 Cystic fibrosis severity; LUSC cis rs11785400 0.793 rs4430070 chr8:143729184 G/C cg24634471 chr8:143751801 JRK 0.51 7.23 0.37 3.35e-12 Schizophrenia; LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg02951883 chr7:2050386 MAD1L1 -0.59 -11.17 -0.52 8.06e-25 Bipolar disorder and schizophrenia; LUSC cis rs2439831 0.850 rs544122 chr15:43775732 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.33 0.41 2.1e-15 Lung cancer in ever smokers; LUSC cis rs7605827 0.866 rs13417550 chr2:15533895 A/G cg19274914 chr2:15703543 NA 0.46 9.07 0.44 1.07e-17 Educational attainment (years of education); LUSC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg01475377 chr6:109611718 NA -0.41 -7.38 -0.37 1.3e-12 Reticulocyte fraction of red cells; LUSC cis rs2346177 1.000 rs12619985 chr2:46641627 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.57 -9.27 -0.45 2.41e-18 HDL cholesterol; LUSC cis rs12681288 0.550 rs60530879 chr8:958381 G/C cg15309053 chr8:964076 NA 0.4 8.23 0.41 4.34e-15 Schizophrenia; LUSC cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg15691649 chr6:25882328 NA -0.38 -6.19 -0.32 1.75e-9 Blood metabolite levels; LUSC cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs4654899 0.714 rs12401630 chr1:21495049 G/A cg02927042 chr1:21476669 EIF4G3 -0.36 -5.65 -0.3 3.5e-8 Superior frontal gyrus grey matter volume; LUSC cis rs6690583 0.623 rs111687161 chr1:85443533 A/G cg11262906 chr1:85462892 MCOLN2 0.69 6.56 0.34 2.1e-10 Serum sulfate level; LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg16405210 chr4:1374714 KIAA1530 -0.53 -7.88 -0.4 4.77e-14 Obesity-related traits; LUSC cis rs4478858 0.735 rs4949393 chr1:31851875 G/A cg00250761 chr1:31883323 NA -0.35 -8.41 -0.42 1.17e-15 Alcohol dependence; LUSC cis rs9300255 0.602 rs1790126 chr12:123683563 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.58 0.34 1.85e-10 Neutrophil percentage of white cells; LUSC trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.95 0.31 6.85e-9 Rheumatoid arthritis; LUSC cis rs4363385 0.747 rs946099 chr1:152971618 A/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.83 -0.39 6.52e-14 Inflammatory skin disease; LUSC cis rs11711311 1.000 rs9826808 chr3:113455644 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg06815965 chr1:205818668 PM20D1 0.39 6.09 0.32 3.16e-9 Menarche (age at onset); LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.54 0.34 2.28e-10 Bipolar disorder; LUSC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg04756594 chr16:24857601 SLC5A11 0.46 6.64 0.34 1.25e-10 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.9e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11048434 0.736 rs7957321 chr12:9120154 C/T cg04155231 chr12:9217510 LOC144571 0.31 5.7 0.3 2.67e-8 Sjögren's syndrome; LUSC trans rs7615952 0.673 rs16834637 chr3:125605471 C/T cg07211511 chr3:129823064 LOC729375 -1.0 -12.35 -0.56 3.95e-29 Blood pressure (smoking interaction); LUSC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg04865166 chr7:105162814 PUS7 0.51 5.84 0.3 1.25e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7582180 0.629 rs13004216 chr2:100945402 G/A cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.722 rs7673476 chr4:120248683 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.42 5.96 0.31 6.45e-9 Corneal astigmatism; LUSC cis rs6060960 0.537 rs6089103 chr20:30464919 G/T cg06102403 chr20:30458708 TTLL9;DUSP15 0.43 5.88 0.31 1.02e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg11752832 chr7:134001865 SLC35B4 0.51 7.74 0.39 1.22e-13 Mean platelet volume; LUSC cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg02753203 chr1:228287806 NA -0.65 -11.16 -0.52 8.28e-25 Diastolic blood pressure; LUSC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg24154853 chr7:158122151 PTPRN2 0.44 8.52 0.42 5.45e-16 Calcium levels; LUSC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.9 0.48 2e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12210905 0.688 rs12212632 chr6:27472416 T/C cg08851530 chr6:28072375 NA 0.95 6.15 0.32 2.21e-9 Hip circumference adjusted for BMI; LUSC trans rs1448094 0.817 rs61929421 chr12:86342330 T/C cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.88e-9 Major depressive disorder; LUSC cis rs72717009 0.778 rs9427400 chr1:161477204 C/T cg23840854 chr1:161414152 NA -0.92 -11.2 -0.52 6.13e-25 Rheumatoid arthritis; LUSC cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Bladder cancer; LUSC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.19 -0.32 1.76e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs61931739 0.782 rs451940 chr12:34196005 T/C cg26384229 chr12:38710491 ALG10B 0.56 9.07 0.44 1.05e-17 Morning vs. evening chronotype; LUSC cis rs11039100 1.000 rs12366070 chr11:5828394 C/T cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg15691649 chr6:25882328 NA 0.5 7.52 0.38 5.12e-13 Blood metabolite levels; LUSC cis rs72781680 1.000 rs56104215 chr2:24133590 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg11266682 chr4:10021025 SLC2A9 0.5 9.17 0.45 5.13e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg25251562 chr2:3704773 ALLC -0.75 -12.42 -0.56 2.26e-29 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs1997103 1.000 rs9642580 chr7:55400359 G/A cg20935933 chr6:143382018 AIG1 0.51 7.36 0.37 1.45e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg13798780 chr7:105162888 PUS7 -0.56 -6.08 -0.32 3.36e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg13397359 chr6:42928475 GNMT 0.58 9.56 0.46 2.58e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6828523 0.640 rs74589934 chr4:175868757 G/A cg16870595 chr4:175839423 ADAM29 0.57 6.31 0.33 8.67e-10 Breast cancer; LUSC cis rs11122272 0.735 rs2808592 chr1:231523757 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs611744 0.870 rs634216 chr8:109174803 A/G cg18478394 chr8:109455254 TTC35 0.41 6.11 0.32 2.82e-9 Dupuytren's disease; LUSC cis rs34172651 0.876 rs2112785 chr16:24781176 C/T cg06028605 chr16:24865363 SLC5A11 0.46 8.1 0.41 1.02e-14 Intelligence (multi-trait analysis); LUSC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg18252515 chr7:66147081 NA -1.25 -13.9 -0.61 5.41e-35 Diabetic kidney disease; LUSC cis rs9473147 0.516 rs9381579 chr6:47556680 C/T cg02130027 chr6:47444894 CD2AP 0.35 5.7 0.3 2.68e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.89 0.48 2.14e-20 Bipolar disorder; LUSC cis rs4474465 0.850 rs7938816 chr11:78266227 T/C cg27205649 chr11:78285834 NARS2 0.54 6.17 0.32 2.03e-9 Alzheimer's disease (survival time); LUSC cis rs10823500 0.636 rs7082396 chr10:71945511 C/A cg26699283 chr10:71892715 AIFM2 -0.4 -6.36 -0.33 6.64e-10 Blood protein levels; LUSC cis rs72615157 0.539 rs2261360 chr7:99692993 G/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.48 6.61 0.34 1.48e-10 Lung function (FEV1/FVC); LUSC cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.76 0.35 6.11e-11 Rheumatoid arthritis; LUSC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg18230493 chr5:56204884 C5orf35 -0.65 -9.99 -0.48 1e-20 Coronary artery disease; LUSC trans rs11696501 0.688 rs6073851 chr20:44306978 C/T cg03272292 chr12:48577362 C12orf68 0.5 5.98 0.31 5.74e-9 Brain structure; LUSC cis rs7267979 1.000 rs6050629 chr20:25430680 G/A cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7712401 0.755 rs6595407 chr5:122100398 C/T cg19077854 chr5:122220652 SNX24 0.35 7.77 0.39 9.65e-14 Mean platelet volume; LUSC trans rs7939886 0.920 rs59300271 chr11:55961792 G/A cg15704280 chr7:45808275 SEPT13 0.89 6.81 0.35 4.56e-11 Myopia (pathological); LUSC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.62 11.16 0.52 8.47e-25 Menopause (age at onset); LUSC cis rs2835872 0.709 rs1709819 chr21:39036115 A/C cg20424643 chr21:39039972 KCNJ6 -0.45 -7.56 -0.38 3.89e-13 Electroencephalographic traits in alcoholism; LUSC trans rs10802346 0.545 rs10802347 chr1:246374268 G/A cg22732515 chr19:44031385 ETHE1 0.63 10.24 0.49 1.36e-21 Fractional exhaled nitric oxide (childhood); LUSC cis rs10986311 0.832 rs9695388 chr9:127141727 C/A cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.38 -6.07 -0.31 3.57e-9 Vitiligo; LUSC cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg15691649 chr6:25882328 NA -0.39 -6.34 -0.33 7.61e-10 Blood metabolite levels; LUSC cis rs9311676 0.632 rs11714389 chr3:58447299 C/T cg13750441 chr3:58318267 PXK 0.32 6.27 0.32 1.12e-9 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24225259 chr2:219575488 TTLL4 -0.41 -6.09 -0.32 3.08e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg06636001 chr8:8085503 FLJ10661 0.62 9.23 0.45 3.23e-18 Mood instability; LUSC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg04362960 chr10:104952993 NT5C2 0.59 9.39 0.46 1e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12701220 0.817 rs59471534 chr7:1085224 G/A cg23978390 chr7:1156363 C7orf50 0.49 6.07 0.32 3.51e-9 Bronchopulmonary dysplasia; LUSC cis rs2295359 1.000 rs10889664 chr1:67635475 C/T cg03340356 chr1:67600835 NA 0.4 6.38 0.33 5.74e-10 Psoriasis; LUSC cis rs7149337 0.804 rs4131981 chr14:51667504 A/T cg23942311 chr14:51606299 NA -0.45 -9.89 -0.48 2.09e-20 Cancer; LUSC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg16060761 chr17:80687452 NA -0.52 -8.07 -0.4 1.27e-14 Glycated hemoglobin levels; LUSC cis rs7072216 0.727 rs942807 chr10:100168219 G/A cg26618903 chr10:100175079 PYROXD2 -0.47 -8.82 -0.43 6.31e-17 Metabolite levels; LUSC cis rs7666738 0.515 rs13142498 chr4:98792443 G/T cg17366294 chr4:99064904 C4orf37 0.56 8.94 0.44 2.61e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.72 10.88 0.51 8.49e-24 Lymphocyte counts; LUSC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg04546413 chr19:29218101 NA 0.7 11.81 0.54 3.88e-27 Methadone dose in opioid dependence; LUSC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg02782426 chr3:40428986 ENTPD3 0.39 6.99 0.36 1.49e-11 Renal cell carcinoma; LUSC cis rs911555 0.655 rs10149470 chr14:104017953 A/G cg12935359 chr14:103987150 CKB -0.54 -9.07 -0.44 1.01e-17 Intelligence (multi-trait analysis); LUSC cis rs7674212 0.539 rs2866635 chr4:104121576 G/A cg16532752 chr4:104119610 CENPE -0.47 -6.8 -0.35 4.81e-11 Type 2 diabetes; LUSC cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg08999081 chr20:33150536 PIGU 0.53 10.53 0.5 1.36e-22 Glomerular filtration rate (creatinine); LUSC cis rs7824557 0.564 rs2736301 chr8:11236413 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.9 -0.31 8.72e-9 Retinal vascular caliber; LUSC cis rs7246657 0.943 rs7255972 chr19:37933841 T/C cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg16145915 chr7:1198662 ZFAND2A -0.61 -11.28 -0.53 3.24e-25 Longevity;Endometriosis; LUSC cis rs3099143 1.000 rs1398241 chr15:77153386 C/T cg21673338 chr15:77095150 SCAPER -0.8 -7.55 -0.38 4.27e-13 Recalcitrant atopic dermatitis; LUSC trans rs62103177 0.525 rs4799117 chr18:77756604 G/A cg05926928 chr17:57297772 GDPD1 -0.88 -10.12 -0.48 3.55e-21 Opioid sensitivity; LUSC trans rs1493916 0.837 rs4992177 chr18:31407020 C/T cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs9393777 0.623 rs3757150 chr6:26476782 T/A cg12826209 chr6:26865740 GUSBL1 0.68 7.67 0.39 1.85e-13 Intelligence (multi-trait analysis); LUSC cis rs6486730 1.000 rs6486730 chr12:129275027 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.42 -6.17 -0.32 1.93e-9 Systemic lupus erythematosus; LUSC cis rs7824557 0.564 rs2736288 chr8:11228100 G/A cg21775007 chr8:11205619 TDH -0.67 -10.41 -0.5 3.53e-22 Retinal vascular caliber; LUSC cis rs892961 0.932 rs35657663 chr17:75412482 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21294209 chr1:46713444 RAD54L -0.42 -6.15 -0.32 2.23e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg13206674 chr6:150067644 NUP43 0.5 7.5 0.38 5.68e-13 Lung cancer; LUSC cis rs9811920 0.535 rs704577 chr3:99487375 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.3 -5.76 -0.3 1.87e-8 Axial length; LUSC cis rs7582180 0.629 rs6757754 chr2:100951273 C/T cg08017756 chr2:100939284 LONRF2 0.43 8.01 0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.78 -0.3 1.71e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs796364 0.806 rs55985986 chr2:201120987 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -7.14 -0.36 5.97e-12 Schizophrenia; LUSC cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg03146154 chr1:46216737 IPP 0.5 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg08213375 chr14:104286397 PPP1R13B 0.43 7.51 0.38 5.47e-13 Reticulocyte count; LUSC cis rs4727027 0.933 rs6955564 chr7:148866173 A/G cg23158103 chr7:148848205 ZNF398 -0.46 -7.4 -0.38 1.12e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg00316803 chr15:76480434 C15orf27 -0.39 -6.68 -0.34 9.79e-11 Blood metabolite levels; LUSC cis rs921968 0.643 rs6708683 chr2:219504503 G/A cg02176678 chr2:219576539 TTLL4 0.59 10.77 0.51 2.08e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg14582100 chr15:45693742 SPATA5L1 -0.55 -10.18 -0.49 2.26e-21 Homoarginine levels; LUSC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg26380479 chr7:97908229 NA -0.27 -5.93 -0.31 7.44e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg08859206 chr1:53392774 SCP2 0.55 9.75 0.47 6.49e-20 Monocyte count; LUSC cis rs9790314 0.967 rs10804790 chr3:161039300 T/A cg03342759 chr3:160939853 NMD3 -0.49 -8.16 -0.41 6.68e-15 Morning vs. evening chronotype; LUSC cis rs1160297 0.576 rs6746666 chr2:53089346 C/T cg07782112 chr2:53107842 NA 0.37 6.32 0.33 8.21e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.6e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9788682 0.947 rs7169584 chr15:78822660 A/T cg06917634 chr15:78832804 PSMA4 -0.59 -7.08 -0.36 8.37e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs208515 0.525 rs4145045 chr6:66678949 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.01 13.77 0.6 1.75e-34 Exhaled nitric oxide levels; LUSC cis rs7917772 0.565 rs1043450 chr10:104434209 A/G cg05855489 chr10:104503620 C10orf26 -0.65 -8.42 -0.42 1.1e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12681288 0.550 rs4410933 chr8:959581 A/G cg15309053 chr8:964076 NA 0.42 8.68 0.43 1.73e-16 Schizophrenia; LUSC cis rs9341808 0.519 rs59232999 chr6:81018783 T/C cg08355045 chr6:80787529 NA -0.42 -7.18 -0.37 4.55e-12 Sitting height ratio; LUSC cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg12935359 chr14:103987150 CKB -0.65 -10.61 -0.5 7.5e-23 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6987853 0.749 rs2974367 chr8:42431194 G/C cg09913449 chr8:42400586 C8orf40 0.5 8.39 0.42 1.41e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.17e-12 Major depressive disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23429847 chr5:128430259 ISOC1 -0.41 -5.96 -0.31 6.53e-9 Electrocardiographic conduction measures; LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg13390004 chr1:15929781 NA 0.4 6.74 0.35 7.14e-11 Systolic blood pressure; LUSC trans rs2164273 0.565 rs2736387 chr8:11157371 A/C cg06636001 chr8:8085503 FLJ10661 0.46 6.89 0.35 2.71e-11 Extraversion; LUSC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg16447950 chr5:562315 NA -0.54 -6.28 -0.32 1.06e-9 Lung disease severity in cystic fibrosis; LUSC cis rs2933343 0.661 rs2630259 chr3:128606322 C/T cg11901034 chr3:128598214 ACAD9 -0.4 -6.21 -0.32 1.57e-9 IgG glycosylation; LUSC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC trans rs208520 0.706 rs851601 chr6:66893853 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -15.31 -0.64 1.92e-40 Exhaled nitric oxide output; LUSC cis rs11229555 1.000 rs12787765 chr11:58400686 G/A cg15696309 chr11:58395628 NA -0.7 -9.28 -0.45 2.12e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.68 -10.61 -0.5 7.54e-23 Hip circumference adjusted for BMI; LUSC cis rs7119 0.700 rs60701760 chr15:77888152 G/A cg27398640 chr15:77910606 LINGO1 0.37 8.6 0.43 3.26e-16 Type 2 diabetes; LUSC cis rs10876993 0.890 rs7976852 chr12:58100551 T/G cg15848620 chr12:58087721 OS9 -0.56 -8.06 -0.4 1.34e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.71 0.43 1.41e-16 Menopause (age at onset); LUSC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg16405210 chr4:1374714 KIAA1530 -0.56 -8.69 -0.43 1.65e-16 Obesity-related traits; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -8.46 -0.42 8.49e-16 Lymphocyte counts; LUSC cis rs6961069 0.806 rs1761665 chr7:80242079 A/G cg04458919 chr7:80252533 CD36 -0.34 -6.17 -0.32 1.93e-9 Platelet count; LUSC cis rs7582180 0.663 rs6542930 chr2:100944383 T/A cg12002119 chr2:101014098 CHST10 0.34 5.7 0.3 2.66e-8 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg07703079 chr11:430292 ANO9 0.65 6.66 0.34 1.11e-10 Body mass index; LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11945232 1.000 rs28372775 chr4:88343704 G/A cg23841344 chr4:88312519 HSD17B11 -0.66 -10.18 -0.49 2.19e-21 Intelligence (multi-trait analysis); LUSC cis rs9638182 0.697 rs12539316 chr7:72977898 C/T cg07452164 chr7:72993570 TBL2 -0.45 -6.43 -0.33 4.32e-10 Triglycerides; LUSC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg02269571 chr22:50332266 NA -0.55 -8.2 -0.41 5.16e-15 Schizophrenia; LUSC cis rs75229567 0.618 rs77168443 chr12:70208563 G/A cg10114359 chr12:70132523 RAB3IP 1.4 12.47 0.56 1.42e-29 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs12936587 0.595 rs9911672 chr17:17528670 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.46 7.37 0.37 1.33e-12 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; LUSC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.59 0.43 3.5e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs16912285 0.688 rs12801480 chr11:24270146 G/A ch.11.24196551F chr11:24239977 NA 0.89 9.68 0.47 1.05e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg23630131 chr7:65973040 NA -0.21 -5.91 -0.31 8.39e-9 Aortic root size; LUSC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg19077165 chr18:44547161 KATNAL2 -0.39 -5.89 -0.31 9.61e-9 Personality dimensions; LUSC cis rs1048238 0.506 rs848209 chr1:16256007 T/C cg21385522 chr1:16154831 NA -0.55 -8.29 -0.41 2.72e-15 Systolic blood pressure; LUSC cis rs6121246 0.567 rs2811 chr20:30194248 A/G cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg04369109 chr6:150039330 LATS1 -0.55 -8.07 -0.4 1.33e-14 Lung cancer; LUSC cis rs7618501 1.000 rs11130219 chr3:49752427 C/T cg13072238 chr3:49761600 GMPPB -0.38 -6.33 -0.33 8.04e-10 Intelligence (multi-trait analysis); LUSC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg06558623 chr16:89946397 TCF25 1.11 9.74 0.47 6.79e-20 Skin colour saturation; LUSC cis rs950169 0.922 rs4842946 chr15:84942331 G/A cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs6969780 0.778 rs2428433 chr7:27145517 T/C cg26364809 chr7:27145159 NA -0.59 -5.98 -0.31 5.69e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs9527 0.615 rs10883800 chr10:104671212 A/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.66 -0.34 1.11e-10 Arsenic metabolism; LUSC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg20283391 chr11:68216788 NA -0.55 -8.13 -0.41 8.23e-15 Total body bone mineral density; LUSC cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg17063962 chr7:91808500 NA 0.58 9.34 0.46 1.35e-18 Breast cancer; LUSC cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg11584989 chr19:19387371 SF4 0.59 6.95 0.36 1.98e-11 Bipolar disorder; LUSC cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg12011299 chr4:100065546 ADH4 0.71 11.07 0.52 1.75e-24 Alcohol dependence; LUSC trans rs56114371 0.777 rs200483 chr6:27774824 C/T cg01620082 chr3:125678407 NA -0.65 -7.09 -0.36 7.84e-12 Breast cancer; LUSC cis rs4969178 0.896 rs12602206 chr17:76397133 A/G cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC trans rs62103177 0.564 rs7228971 chr18:77738025 C/T cg05926928 chr17:57297772 GDPD1 -0.96 -10.67 -0.5 4.73e-23 Opioid sensitivity; LUSC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg06634786 chr22:41940651 POLR3H -0.55 -6.73 -0.35 7.44e-11 Vitiligo; LUSC cis rs6845621 0.901 rs1079812 chr4:18925913 A/C cg12196642 chr4:18937545 NA -0.35 -6.57 -0.34 1.91e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg07061783 chr6:25882402 NA 0.43 6.07 0.32 3.5e-9 Blood metabolite levels; LUSC cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg13010199 chr12:38710504 ALG10B 0.66 10.03 0.48 7.06e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg27170947 chr2:26402098 FAM59B -0.64 -9.3 -0.45 1.88e-18 Gut microbiome composition (summer); LUSC cis rs96067 0.652 rs274137 chr1:36577945 A/G cg27506609 chr1:36549197 TEKT2 -0.66 -9.15 -0.45 5.72e-18 Corneal structure; LUSC trans rs4295623 0.553 rs11250163 chr8:11596437 G/T cg27411982 chr8:10470053 RP1L1 0.41 6.55 0.34 2.19e-10 Morning vs. evening chronotype; LUSC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11644478 chr21:40555479 PSMG1 -0.75 -13.03 -0.58 1.21e-31 Cognitive function; LUSC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg08270630 chr22:50330655 NA 0.41 6.05 0.31 3.98e-9 Schizophrenia; LUSC cis rs7267979 0.966 rs6037097 chr20:25347221 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.87 20.23 0.74 5.89e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg18190219 chr22:46762943 CELSR1 -0.55 -6.38 -0.33 5.88e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg03188948 chr7:1209495 NA 0.62 6.51 0.34 2.73e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs208520 0.690 rs74707865 chr6:66717352 A/G cg07460842 chr6:66804631 NA 1.1 17.18 0.68 7.82e-48 Exhaled nitric oxide output; LUSC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg05802129 chr4:122689817 NA -0.47 -7.92 -0.4 3.55e-14 Type 2 diabetes; LUSC cis rs4253772 0.575 rs9615979 chr22:46789021 G/T cg24881330 chr22:46731750 TRMU 0.82 6.01 0.31 4.92e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg04944784 chr2:26401820 FAM59B -0.74 -10.67 -0.5 4.6e-23 Gut microbiome composition (summer); LUSC cis rs427394 0.802 rs274692 chr5:6734625 C/T cg10857441 chr5:6722123 POLS -0.47 -9.08 -0.44 9.73e-18 Menopause (age at onset); LUSC cis rs4595586 0.546 rs11609849 chr12:39258090 C/G cg26384229 chr12:38710491 ALG10B 0.79 11.89 0.55 1.95e-27 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21950561 chr5:61699692 DIMT1L -0.41 -6.08 -0.32 3.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11640436 0.651 rs11643318 chr16:77322757 C/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.37 5.72 0.3 2.31e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs877282 0.583 rs112372193 chr10:826602 A/G cg22713356 chr15:30763199 NA 0.77 10.03 0.48 7.44e-21 Uric acid levels; LUSC cis rs1801251 1.000 rs67013068 chr2:233608253 G/C cg08000102 chr2:233561755 GIGYF2 0.68 11.36 0.53 1.61e-25 Coronary artery disease; LUSC cis rs12410462 0.579 rs115037090 chr1:227666191 A/G cg23173402 chr1:227635558 NA 0.77 8.17 0.41 6.32e-15 Major depressive disorder; LUSC cis rs2996428 0.667 rs2368534 chr1:3740640 C/T cg13057898 chr1:3703894 LRRC47 0.5 8.35 0.42 1.9e-15 Red cell distribution width; LUSC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg13531842 chr10:38383804 ZNF37A -0.45 -6.99 -0.36 1.48e-11 Extrinsic epigenetic age acceleration; LUSC cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg01483505 chr11:975446 AP2A2 -0.4 -5.82 -0.3 1.38e-8 Alzheimer's disease (late onset); LUSC cis rs7568458 0.783 rs2166529 chr2:85742175 A/C cg02493740 chr2:85810744 VAMP5 0.41 7.47 0.38 7.08e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs12464559 0.649 rs4664496 chr2:152522556 T/C cg01189475 chr2:152685088 ARL5A -0.57 -6.26 -0.32 1.18e-9 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg14298792 chr15:30685198 CHRFAM7A -0.69 -8.87 -0.44 4.43e-17 Huntington's disease progression; LUSC cis rs7615952 0.546 rs2922171 chr3:125343193 C/T cg05084668 chr3:125655381 ALG1L -0.45 -6.02 -0.31 4.67e-9 Blood pressure (smoking interaction); LUSC cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC cis rs17292804 0.527 rs12887734 chr14:104046834 G/T cg04998671 chr14:104000505 TRMT61A -0.47 -6.81 -0.35 4.52e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs12950390 0.853 rs66471233 chr17:45867086 C/T cg06532163 chr17:45867833 NA 0.36 6.63 0.34 1.37e-10 IgG glycosylation; LUSC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg01657329 chr11:68192670 LRP5 0.45 6.69 0.34 9.28e-11 Total body bone mineral density; LUSC cis rs908922 0.676 rs4845789 chr1:152528100 A/G cg20991723 chr1:152506922 NA 0.49 9.23 0.45 3.09e-18 Hair morphology; LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg08888203 chr3:10149979 C3orf24 0.66 9.28 0.45 2.15e-18 Alzheimer's disease; LUSC trans rs853679 0.607 rs17763089 chr6:27835218 G/A cg01620082 chr3:125678407 NA -0.82 -7.32 -0.37 1.84e-12 Depression; LUSC cis rs500891 0.553 rs2154295 chr6:84170784 C/G cg08257003 chr6:84140564 ME1 0.35 8.67 0.43 1.87e-16 Platelet-derived growth factor BB levels; LUSC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.14 -0.32 2.34e-9 Major depressive disorder; LUSC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7582180 0.629 rs13031906 chr2:100939524 T/C cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.89e-8 Intelligence (multi-trait analysis); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg12601414 chr9:115249737 KIAA1958 -0.56 -6.36 -0.33 6.58e-10 Height; LUSC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg14893161 chr1:205819251 PM20D1 0.42 5.69 0.3 2.78e-8 Parkinson's disease; LUSC cis rs4363385 0.510 rs17627288 chr1:152923848 C/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.25 -0.32 1.22e-9 Inflammatory skin disease; LUSC cis rs9527 0.615 rs17725614 chr10:104685493 G/C cg04362960 chr10:104952993 NT5C2 0.59 9.23 0.45 3.21e-18 Arsenic metabolism; LUSC cis rs11122272 0.735 rs2244994 chr1:231537127 C/G cg06096015 chr1:231504339 EGLN1 0.57 10.04 0.48 6.89e-21 Hemoglobin concentration; LUSC cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg00071950 chr4:10020882 SLC2A9 -0.59 -10.1 -0.48 4.14e-21 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7246967 0.673 rs12979173 chr19:22820681 C/T cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.47e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs4595586 0.756 rs1400283 chr12:39364596 G/C cg26384229 chr12:38710491 ALG10B 0.5 6.99 0.36 1.48e-11 Morning vs. evening chronotype; LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg11494091 chr17:61959527 GH2 0.64 13.48 0.59 2.35e-33 Prudent dietary pattern; LUSC cis rs7512552 0.780 rs2794681 chr1:150321951 C/T cg15654264 chr1:150340011 RPRD2 0.68 11.51 0.53 4.95e-26 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg25643088 chr3:52874325 TMEM110 0.4 6.14 0.32 2.37e-9 Schizophrenia; LUSC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.62 6.04 0.31 4.07e-9 Cerebrospinal P-tau181p levels; LUSC cis rs9611519 1.000 rs5758268 chr22:41622419 A/T cg03806693 chr22:41940476 POLR3H -0.47 -6.45 -0.33 3.82e-10 Neuroticism; LUSC cis rs11264799 0.520 rs849820 chr1:157541565 G/C cg18268488 chr1:157545234 FCRL4 0.38 7.37 0.37 1.38e-12 IgA nephropathy; LUSC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg16447950 chr5:562315 NA -0.56 -6.88 -0.35 2.9e-11 Obesity-related traits; LUSC trans rs9561329 0.528 rs1323986 chr13:93999772 A/G cg19275536 chr6:52926650 ICK 0.49 6.27 0.32 1.13e-9 Neuroticism (age interaction); LUSC cis rs1801251 1.000 rs283484 chr2:233646505 A/G cg08000102 chr2:233561755 GIGYF2 0.71 11.67 0.54 1.3e-26 Coronary artery disease; LUSC cis rs12950390 0.853 rs11079790 chr17:45853626 G/A cg03474202 chr17:45855739 NA -0.29 -6.69 -0.34 9.51e-11 IgG glycosylation; LUSC trans rs10843647 0.935 rs2351219 chr12:30319380 C/T cg16899367 chr7:73097788 WBSCR22;DNAJC30 0.64 6.11 0.32 2.71e-9 Glucose homeostasis traits; LUSC trans rs1005277 0.557 rs176887 chr10:38406094 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.65 -0.47 1.39e-19 Extrinsic epigenetic age acceleration; LUSC cis rs722599 0.715 rs2300598 chr14:75359229 T/C cg06637938 chr14:75390232 RPS6KL1 -0.41 -5.96 -0.31 6.42e-9 IgG glycosylation; LUSC trans rs7567288 0.636 rs12993449 chr2:134463168 G/C cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06170053 chr6:21596959 SOX4 -0.44 -6.42 -0.33 4.8e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs72792513 1.000 rs72796597 chr2:22883689 G/A cg05844895 chr16:88969569 CBFA2T3 0.52 6.2 0.32 1.63e-9 Hepatitis B; LUSC cis rs1577917 0.837 rs10944157 chr6:86577199 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.13 -0.32 2.42e-9 Response to antipsychotic treatment; LUSC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs8060686 0.623 rs6499162 chr16:68239460 T/C cg26727032 chr16:67993705 SLC12A4 -0.4 -5.99 -0.31 5.32e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.49 0.38 6.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs243505 0.898 rs243532 chr7:148412371 A/G cg09806900 chr7:148480153 CUL1 -0.47 -6.62 -0.34 1.41e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg04267008 chr7:1944627 MAD1L1 -0.51 -7.5 -0.38 5.93e-13 Bipolar disorder and schizophrenia; LUSC cis rs2354432 0.891 rs2165743 chr1:146690319 C/T cg25205988 chr1:146714368 CHD1L 1.07 12.63 0.57 3.82e-30 Mitochondrial DNA levels; LUSC cis rs3741151 0.656 rs112699563 chr11:73015243 C/T cg17517138 chr11:73019481 ARHGEF17 0.92 8.39 0.42 1.44e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18588027 chr15:68132741 NA 0.7 6.01 0.31 4.78e-9 Cognitive performance; LUSC trans rs9291683 0.546 rs10939672 chr4:10052136 A/G cg26043149 chr18:55253948 FECH 0.47 6.87 0.35 3.21e-11 Bone mineral density; LUSC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg12823233 chr7:2316876 SNX8 -0.34 -5.83 -0.3 1.28e-8 Schizophrenia; LUSC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg21854759 chr1:92012499 NA -0.53 -8.99 -0.44 1.89e-17 Breast cancer; LUSC cis rs9987353 0.566 rs13260067 chr8:9071033 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.43 -0.33 4.45e-10 Recombination measurement; LUSC cis rs295140 1.000 rs13026151 chr2:201164570 T/A cg04283868 chr2:201171347 SPATS2L 0.44 6.63 0.34 1.36e-10 QT interval; LUSC cis rs926392 0.547 rs8118808 chr20:37674996 C/G cg16355469 chr20:37678765 NA 0.53 7.04 0.36 1.12e-11 Dialysis-related mortality; LUSC cis rs12122100 0.837 rs12742539 chr1:146507845 G/A cg03526459 chr1:146549940 NA -0.41 -6.66 -0.34 1.11e-10 HIV-1 control; LUSC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg22535103 chr8:58192502 C8orf71 -0.73 -9.16 -0.45 5.46e-18 Developmental language disorder (linguistic errors); LUSC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.88 0.35 3.04e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs295140 0.546 rs295119 chr2:201117944 C/T cg23649088 chr2:200775458 C2orf69 0.43 6.36 0.33 6.72e-10 QT interval; LUSC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg06808227 chr14:105710500 BRF1 -0.64 -9.6 -0.47 1.94e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs9325144 0.555 rs7968322 chr12:38792348 T/C cg26384229 chr12:38710491 ALG10B -0.61 -9.39 -0.46 9.45e-19 Morning vs. evening chronotype; LUSC cis rs11122272 0.701 rs2790894 chr1:231505587 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.85 -0.47 2.99e-20 Hemoglobin concentration; LUSC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg12524338 chr4:183729343 NA 0.69 9.38 0.46 1.08e-18 Pediatric autoimmune diseases; LUSC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg24881330 chr22:46731750 TRMU 0.85 7.57 0.38 3.77e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.83 10.81 0.51 1.47e-23 Schizophrenia; LUSC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg13628971 chr7:2884303 GNA12 0.45 6.38 0.33 6.04e-10 Height; LUSC cis rs2250402 0.510 rs2898984 chr15:40324075 G/C cg10636054 chr15:40330586 SRP14 0.92 9.07 0.44 1.08e-17 Corneal curvature; LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg22920501 chr2:26401640 FAM59B 0.8 11.94 0.55 1.33e-27 Gut microbiome composition (summer); LUSC trans rs7824557 0.767 rs11250127 chr8:11170209 G/A cg08975724 chr8:8085496 FLJ10661 0.46 6.74 0.35 6.94e-11 Retinal vascular caliber; LUSC cis rs3789045 0.560 rs1107339 chr1:204411942 C/T cg17419461 chr1:204415978 PIK3C2B -0.51 -5.77 -0.3 1.77e-8 Educational attainment (college completion); LUSC cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg17063962 chr7:91808500 NA 0.59 9.36 0.46 1.22e-18 Breast cancer; LUSC cis rs9650315 0.929 rs11994717 chr8:57160043 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.48 6.83 0.35 3.91e-11 Height; LUSC cis rs735860 0.726 rs209518 chr6:53208016 C/A cg10236188 chr6:53219634 NA 0.38 5.66 0.3 3.33e-8 Glaucoma; LUSC trans rs617791 0.669 rs4994056 chr11:65750997 G/A cg17712092 chr4:129076599 LARP1B 0.73 11.12 0.52 1.15e-24 Breast cancer; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg08280861 chr8:58055591 NA 0.57 6.03 0.31 4.4e-9 Developmental language disorder (linguistic errors); LUSC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg10556349 chr10:835070 NA 0.59 6.48 0.33 3.31e-10 Eosinophil percentage of granulocytes; LUSC cis rs459571 0.959 rs460888 chr9:136913123 C/G cg13789015 chr9:136890014 NCRNA00094 0.71 12.81 0.57 8.06e-31 Platelet distribution width; LUSC cis rs708547 1.000 rs708547 chr4:57821309 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.58 7.22 0.37 3.43e-12 Response to bleomycin (chromatid breaks); LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg06387496 chr7:2775674 GNA12 -0.36 -5.68 -0.3 2.9e-8 Height; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg10802521 chr3:52805072 NEK4 -0.43 -6.7 -0.34 8.64e-11 Electroencephalogram traits; LUSC cis rs9400467 0.508 rs11153293 chr6:111725899 A/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.89 -0.35 2.72e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.36 5.83 0.3 1.28e-8 IgG glycosylation; LUSC cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg23158103 chr7:148848205 ZNF398 -0.5 -8.45 -0.42 9.1e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs5758511 0.731 rs12158579 chr22:42351289 C/T cg00645731 chr22:42541494 CYP2D7P1 0.43 7.18 0.37 4.67e-12 Birth weight; LUSC trans rs8072100 0.967 rs4580230 chr17:45738861 G/A cg04995722 chr7:26192034 NFE2L3 -0.37 -6.0 -0.31 5.25e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12421382 0.614 rs12420249 chr11:109390254 T/G cg16359550 chr11:109292809 C11orf87 0.32 5.78 0.3 1.67e-8 Schizophrenia; LUSC cis rs7113850 0.541 rs75850541 chr11:24211467 C/G ch.11.24196551F chr11:24239977 NA 0.98 7.5 0.38 5.69e-13 Bone fracture in osteoporosis; LUSC cis rs8179 0.761 rs42034 chr7:92239144 A/G cg15732164 chr7:92237376 CDK6 -0.48 -6.58 -0.34 1.82e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs7215564 0.643 rs59992540 chr17:78658265 G/A cg09596252 chr17:78655493 RPTOR 0.55 6.04 0.31 4.18e-9 Myopia (pathological); LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs9311676 0.656 rs11918201 chr3:58387777 C/T cg26110898 chr3:58419937 PDHB 0.4 6.49 0.33 3.05e-10 Systemic lupus erythematosus; LUSC trans rs2392780 0.536 rs400818 chr8:128336546 T/C cg10195415 chr17:73887371 TRIM65 0.42 6.66 0.34 1.11e-10 Breast cancer (early onset); LUSC cis rs6736093 0.966 rs71414616 chr2:112696684 T/C cg12686935 chr2:112915763 FBLN7 -0.37 -5.9 -0.31 8.73e-9 Coronary artery disease; LUSC cis rs826838 0.585 rs12296822 chr12:38625829 A/T cg26384229 chr12:38710491 ALG10B -0.56 -8.45 -0.42 8.99e-16 Heart rate; LUSC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 6.2 0.32 1.64e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs834603 0.575 rs1799370 chr7:47467864 C/T cg09696706 chr7:47479511 TNS3 0.32 5.75 0.3 2.01e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg10356904 chr22:49881777 NA 0.33 7.61 0.38 2.85e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg24578937 chr1:2090814 PRKCZ -0.41 -9.13 -0.45 6.91e-18 Height; LUSC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg12412775 chr1:25698385 RHCE -0.29 -5.95 -0.31 6.65e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg11244672 chr19:19639970 YJEFN3 -0.58 -7.32 -0.37 1.84e-12 Bipolar disorder; LUSC cis rs7568458 0.507 rs719023 chr2:85818488 A/G cg23752985 chr2:85803571 VAMP8 -0.29 -6.03 -0.31 4.36e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs877282 0.898 rs11253343 chr10:765117 C/T cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs59698941 0.943 rs67460003 chr5:132289501 C/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg05313129 chr8:58192883 C8orf71 -0.53 -6.84 -0.35 3.89e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg26441486 chr22:50317300 CRELD2 0.47 6.54 0.34 2.31e-10 Schizophrenia; LUSC cis rs7131987 0.903 rs7974221 chr12:29399448 A/G cg09582351 chr12:29534625 ERGIC2 -0.32 -6.7 -0.34 9.06e-11 QT interval; LUSC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg04998671 chr14:104000505 TRMT61A -0.42 -5.93 -0.31 7.75e-9 Reticulocyte count; LUSC cis rs208520 1.000 rs72884025 chr6:66994185 T/C cg07460842 chr6:66804631 NA 0.93 12.09 0.55 3.65e-28 Exhaled nitric oxide output; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg23131131 chr22:24373011 LOC391322 -0.5 -6.86 -0.35 3.33e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1728785 1.000 rs1170426 chr16:68603798 C/T cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg19729930 chr2:74357872 NA -0.85 -15.6 -0.65 1.32e-41 Gestational age at birth (maternal effect); LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg03354898 chr7:1950403 MAD1L1 -0.36 -7.05 -0.36 1.05e-11 Bipolar disorder and schizophrenia; LUSC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg05872129 chr22:39784769 NA -0.56 -9.51 -0.46 4e-19 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg01341218 chr17:43662625 NA -0.76 -11.05 -0.52 2.07e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs61931739 0.500 rs35391785 chr12:34444478 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.75 0.65 3.58e-42 Morning vs. evening chronotype; LUSC cis rs7106204 0.748 rs11820336 chr11:24219701 G/A ch.11.24196551F chr11:24239977 NA 1.14 14.14 0.61 6.98e-36 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1994135 0.565 rs11052767 chr12:33731194 A/G cg06521331 chr12:34319734 NA -0.41 -5.96 -0.31 6.36e-9 Resting heart rate; LUSC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg12641515 chr19:46296257 DMWD 0.48 7.1 0.36 7.52e-12 Coronary artery disease; LUSC cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg04998671 chr14:104000505 TRMT61A -0.4 -6.02 -0.31 4.48e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs710216 0.917 rs900834 chr1:43412343 A/G cg03128534 chr1:43423976 SLC2A1 -0.48 -6.05 -0.31 3.83e-9 Red cell distribution width; LUSC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg18305652 chr10:134549665 INPP5A 0.45 6.77 0.35 5.66e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs7100689 0.646 rs1047952 chr10:82126808 C/G cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg22638593 chr5:131593259 PDLIM4 0.4 5.7 0.3 2.66e-8 Breast cancer; LUSC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg23262073 chr20:60523788 NA -0.46 -6.81 -0.35 4.43e-11 Body mass index; LUSC cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg04450456 chr4:17643702 FAM184B -0.37 -6.18 -0.32 1.81e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg25036284 chr2:26402008 FAM59B -0.47 -6.12 -0.32 2.62e-9 Gut microbiome composition (summer); LUSC cis rs5167 0.743 rs8111069 chr19:45483438 A/C cg13119609 chr19:45449297 APOC2 0.34 5.8 0.3 1.57e-8 Blood protein levels; LUSC cis rs4466137 0.951 rs336958 chr5:82973396 A/G cg16102102 chr5:83017553 HAPLN1 -0.82 -12.24 -0.56 1.02e-28 Prostate cancer; LUSC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg16049864 chr8:95962084 TP53INP1 -0.66 -12.3 -0.56 6.3e-29 Type 2 diabetes; LUSC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg22709100 chr7:91322751 NA -0.42 -6.11 -0.32 2.72e-9 Breast cancer; LUSC cis rs10186029 0.509 rs10194726 chr2:213936876 G/A cg08319019 chr2:214017104 IKZF2 -0.43 -6.25 -0.32 1.26e-9 Systemic sclerosis; LUSC cis rs1346 0.552 rs4326800 chr11:65367253 C/T cg17120908 chr11:65337727 SSSCA1 -0.41 -5.68 -0.3 2.94e-8 Vertical cup-disc ratio;Optic cup area; LUSC cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg13010199 chr12:38710504 ALG10B 0.65 10.01 0.48 8.37e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7178572 0.625 rs907372 chr15:77844516 G/T cg22256960 chr15:77711686 NA -0.43 -6.85 -0.35 3.61e-11 Type 2 diabetes; LUSC cis rs6681460 0.625 rs2872079 chr1:67130071 G/A cg02459107 chr1:67143332 SGIP1 0.33 5.76 0.3 1.91e-8 Presence of antiphospholipid antibodies; LUSC cis rs12477438 0.765 rs2278895 chr2:99613484 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.68 -0.57 2.41e-30 Chronic sinus infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08169830 chr7:97822374 LMTK2 -0.39 -6.12 -0.32 2.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg11266682 chr4:10021025 SLC2A9 -0.51 -9.58 -0.46 2.31e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg22117172 chr7:91764530 CYP51A1 0.33 5.82 0.3 1.36e-8 Breast cancer; LUSC cis rs68170813 0.523 rs11766131 chr7:107071138 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.26 -0.45 2.55e-18 Coronary artery disease; LUSC cis rs34779708 0.931 rs35136660 chr10:35385973 C/A cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg05585544 chr11:47624801 NA -0.41 -7.33 -0.37 1.74e-12 Subjective well-being; LUSC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg21854759 chr1:92012499 NA -0.57 -9.85 -0.47 2.93e-20 Breast cancer; LUSC cis rs10100465 0.961 rs10093232 chr8:118679361 A/T cg09430518 chr8:118662568 NA 0.3 5.69 0.3 2.72e-8 Leprosy; LUSC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.45 7.26 0.37 2.66e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9308433 0.643 rs7412913 chr1:214463228 G/A cg06198575 chr1:214491504 SMYD2 0.45 6.85 0.35 3.5e-11 IgG glycosylation; LUSC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg24642844 chr7:1081250 C7orf50 -0.45 -7.28 -0.37 2.41e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs34421088 0.506 rs4841519 chr8:11146228 A/T cg06636001 chr8:8085503 FLJ10661 0.46 7.26 0.37 2.68e-12 Neuroticism; LUSC cis rs7193541 0.684 rs4888265 chr16:74683737 T/C cg01733217 chr16:74700730 RFWD3 0.98 22.58 0.78 3.49e-69 Multiple myeloma; LUSC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg18404041 chr3:52824283 ITIH1 -0.51 -9.65 -0.47 1.32e-19 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02939508 chr14:21152672 RNASE4;ANG 0.48 6.54 0.34 2.31e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg23985595 chr17:80112537 CCDC57 0.31 5.97 0.31 6.13e-9 Life satisfaction; LUSC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg05472934 chr7:22766657 IL6 0.5 7.84 0.39 6.13e-14 Lung cancer; LUSC cis rs17102423 0.594 rs7159443 chr14:65550816 T/A cg11161011 chr14:65562177 MAX -0.72 -11.07 -0.52 1.85e-24 Obesity-related traits; LUSC trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.72 -0.35 7.77e-11 Monocyte count; LUSC cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg09085632 chr11:111637200 PPP2R1B 1.16 18.4 0.71 1.09e-52 Primary sclerosing cholangitis; LUSC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.86 11.47 0.53 6.92e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10791097 0.690 rs12284540 chr11:130729772 T/C cg12179176 chr11:130786555 SNX19 0.74 12.12 0.55 2.8e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg08499158 chr17:42289980 UBTF 0.56 9.12 0.45 7.32e-18 Total body bone mineral density; LUSC cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg24558204 chr6:135376177 HBS1L 0.68 10.58 0.5 9.61e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6580649 0.941 rs7963934 chr12:48477086 C/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.26 -0.37 2.71e-12 Menopause (age at onset); LUSC cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg24642439 chr20:33292090 TP53INP2 -0.49 -7.42 -0.38 9.53e-13 Glomerular filtration rate (creatinine); LUSC trans rs2905347 0.757 rs2961295 chr7:22696272 C/T cg09038599 chr8:57233391 SDR16C5 0.28 6.04 0.31 4.1e-9 Major depression and alcohol dependence; LUSC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.13 -0.41 8.24e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg03929089 chr4:120376271 NA -0.88 -11.86 -0.54 2.57e-27 Coronary artery disease; LUSC cis rs34779708 0.966 rs17591857 chr10:35499043 A/G cg04310649 chr10:35416472 CREM 0.41 6.34 0.33 7.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2629540 0.731 rs11245341 chr10:126408777 G/C cg08799069 chr10:126477246 METTL10 0.6 8.24 0.41 3.98e-15 Cocaine dependence; LUSC cis rs2658782 0.951 rs117384439 chr11:93111478 T/G cg15737290 chr11:93063684 CCDC67 -0.59 -7.0 -0.36 1.4e-11 Pulmonary function decline; LUSC cis rs12579753 0.917 rs2401003 chr12:82215192 G/A cg21231944 chr12:82153410 PPFIA2 -0.38 -5.73 -0.3 2.27e-8 Resting heart rate; LUSC trans rs11992162 0.621 rs13268810 chr8:11797430 A/T cg15556689 chr8:8085844 FLJ10661 0.48 6.83 0.35 4.01e-11 Monocyte count; LUSC cis rs11214589 0.870 rs10789942 chr11:113236199 C/T cg14159747 chr11:113255604 NA -0.28 -7.03 -0.36 1.19e-11 Neuroticism; LUSC cis rs4595586 0.525 rs35046524 chr12:39414535 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.38 4.39e-13 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs314370 0.951 rs17881696 chr7:100493359 G/A cg08558340 chr7:100472263 SRRT 0.51 6.27 0.32 1.11e-9 Resting heart rate; LUSC cis rs11997175 0.624 rs4355732 chr8:33676920 A/C ch.8.33884649F chr8:33765107 NA 0.47 7.11 0.36 7.19e-12 Body mass index; LUSC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg11663144 chr21:46675770 NA -0.41 -7.23 -0.37 3.33e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs394563 0.591 rs237029 chr6:149717425 A/G cg03678062 chr6:149772716 ZC3H12D -0.31 -6.32 -0.33 8.38e-10 Dupuytren's disease; LUSC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.54 7.5 0.38 5.84e-13 Multiple sclerosis; LUSC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg25019033 chr10:957182 NA -0.53 -5.83 -0.3 1.28e-8 Eosinophil percentage of granulocytes; LUSC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg01416388 chr22:39784598 NA -0.43 -7.09 -0.36 8.24e-12 Intelligence (multi-trait analysis); LUSC trans rs877282 0.838 rs11253408 chr10:796374 T/C cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs887829 0.570 rs4553819 chr2:234594083 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.31 -0.33 8.87e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs9649213 0.574 rs17436977 chr7:97883459 T/C cg21770322 chr7:97807741 LMTK2 0.45 7.57 0.38 3.6e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs1018836 0.923 rs2023626 chr8:91619264 G/T cg16814680 chr8:91681699 NA 0.77 12.73 0.57 1.55e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg17366294 chr4:99064904 C4orf37 0.54 8.86 0.44 4.93e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs11828289 0.660 rs77575887 chr11:23174504 T/A cg20040320 chr11:23191996 NA -0.58 -6.09 -0.32 3.05e-9 Cancer; LUSC cis rs4363385 0.747 rs3806219 chr1:152972522 C/T cg25856811 chr1:152973957 SPRR3 0.34 5.79 0.3 1.58e-8 Inflammatory skin disease; LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg20887711 chr4:1340912 KIAA1530 0.44 6.67 0.34 1.09e-10 Obesity-related traits; LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg22907277 chr7:1156413 C7orf50 0.72 7.56 0.38 4.05e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg11941060 chr3:133502564 NA -0.52 -8.12 -0.41 8.94e-15 Iron status biomarkers; LUSC cis rs710216 0.917 rs1681859 chr1:43411829 G/A cg22176566 chr1:43424700 SLC2A1 0.49 6.22 0.32 1.53e-9 Red cell distribution width; LUSC cis rs34779708 0.931 rs4934704 chr10:35332164 C/T cg03585969 chr10:35415529 CREM 0.62 8.91 0.44 3.39e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg08847533 chr14:75593920 NEK9 0.8 13.95 0.61 3.72e-35 Height; LUSC cis rs3806843 0.676 rs2563304 chr5:140072057 C/T cg19875535 chr5:140030758 IK -0.53 -8.76 -0.43 1.02e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs9323205 0.862 rs11629399 chr14:51612814 T/C cg23942311 chr14:51606299 NA -0.5 -10.24 -0.49 1.39e-21 Cancer; LUSC cis rs7940866 0.903 rs10750457 chr11:130850277 T/C cg12179176 chr11:130786555 SNX19 0.57 9.06 0.44 1.09e-17 Schizophrenia; LUSC cis rs4969178 0.965 rs16971107 chr17:76394042 C/T cg05887092 chr17:76393375 PGS1 0.51 9.38 0.46 1.03e-18 HDL cholesterol levels; LUSC cis rs807669 0.903 rs2800974 chr22:19168087 C/T cg02655711 chr22:19163373 SLC25A1 0.87 17.54 0.69 2.79e-49 Metabolite levels; LUSC cis rs12760731 0.623 rs16852708 chr1:178308249 T/G cg00404053 chr1:178313656 RASAL2 0.47 5.81 0.3 1.48e-8 Obesity-related traits; LUSC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9581857 0.547 rs9581869 chr13:28082498 G/A cg22138327 chr13:27999177 GTF3A 0.69 7.16 0.36 5.24e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs950169 0.922 rs4338765 chr15:84916836 G/T cg12863693 chr15:85201151 NMB 0.36 7.35 0.37 1.56e-12 Schizophrenia; LUSC cis rs477692 0.935 rs568918 chr10:131414455 A/G cg11019008 chr10:131425282 MGMT 0.41 6.36 0.33 6.79e-10 Response to temozolomide; LUSC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg20135002 chr11:47629003 NA -0.52 -8.08 -0.4 1.17e-14 Subjective well-being; LUSC cis rs7119167 0.686 rs7123298 chr11:73038820 C/T cg17517138 chr11:73019481 ARHGEF17 0.5 5.85 0.3 1.16e-8 Blood protein levels; LUSC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg00033643 chr7:134001901 SLC35B4 0.44 6.73 0.35 7.51e-11 Mean platelet volume; LUSC cis rs72781680 1.000 rs56339200 chr2:24188194 C/A cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg08677398 chr8:58056175 NA 0.44 6.39 0.33 5.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs10761482 0.861 rs4948405 chr10:62108419 G/T cg18175470 chr10:62150864 ANK3 -0.5 -7.1 -0.36 7.67e-12 Schizophrenia; LUSC cis rs6754311 0.773 rs188680 chr2:136630989 A/G cg07169764 chr2:136633963 MCM6 -0.57 -7.67 -0.39 1.95e-13 Mosquito bite size; LUSC cis rs77741769 0.571 rs61946382 chr12:121344574 A/T cg02419362 chr12:121203948 SPPL3 0.46 8.64 0.43 2.32e-16 Mean corpuscular volume; LUSC cis rs925255 0.743 rs7600164 chr2:28644862 A/T cg01273330 chr2:28605224 NA -0.38 -6.15 -0.32 2.26e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2425143 0.818 rs12481545 chr20:34407698 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -5.99 -0.31 5.47e-9 Blood protein levels; LUSC cis rs62400317 0.762 rs62436411 chr6:44940706 T/G cg20913747 chr6:44695427 NA -0.45 -7.1 -0.36 7.39e-12 Total body bone mineral density; LUSC cis rs9549367 0.664 rs9549689 chr13:113848387 G/A cg18105134 chr13:113819100 PROZ -0.76 -10.64 -0.5 5.78e-23 Platelet distribution width; LUSC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg09455208 chr3:40491958 NA 0.58 10.22 0.49 1.66e-21 Renal cell carcinoma; LUSC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg06634786 chr22:41940651 POLR3H 0.5 5.89 0.31 9.64e-9 Vitiligo; LUSC cis rs12950390 0.853 rs8071192 chr17:45856141 A/G cg03474202 chr17:45855739 NA -0.29 -6.67 -0.34 1.07e-10 IgG glycosylation; LUSC cis rs9399135 0.967 rs9402676 chr6:135355507 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.24 0.45 2.88e-18 Red blood cell count; LUSC cis rs7903847 0.642 rs11812223 chr10:99158455 T/C cg08345082 chr10:99160200 RRP12 -0.36 -7.17 -0.37 4.83e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg06238570 chr21:40685208 BRWD1 0.47 7.38 0.37 1.27e-12 Cognitive function; LUSC cis rs7569084 0.566 rs7584295 chr2:65581074 T/C cg08085232 chr2:65598271 SPRED2 -0.43 -6.75 -0.35 6.74e-11 Sum eosinophil basophil counts; LUSC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs7267979 0.844 rs6132824 chr20:25238173 T/C cg08601574 chr20:25228251 PYGB 0.55 8.83 0.44 5.91e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7647973 1.000 rs2140270 chr3:49439440 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.46 -6.99 -0.36 1.53e-11 Menarche (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02310229 chr5:32312285 MTMR12 0.37 5.99 0.31 5.56e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1983170 0.668 rs17131491 chr1:92017649 A/C cg25838465 chr1:92012736 NA 0.47 5.82 0.3 1.4e-8 Eosinophil percentage of white cells; LUSC trans rs7824557 0.510 rs2736297 chr8:11234885 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.76 -0.39 1.06e-13 Retinal vascular caliber; LUSC cis rs12042938 0.507 rs1765778 chr1:231732356 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.68 -11.24 -0.52 4.52e-25 Neuranatomic and neurocognitive phenotypes; LUSC cis rs11098499 0.863 rs10030660 chr4:120436704 G/A cg09307838 chr4:120376055 NA 0.73 10.33 0.49 6.88e-22 Corneal astigmatism; LUSC cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.78 0.39 9.22e-14 Colorectal cancer; LUSC cis rs3806843 1.000 rs6885319 chr5:140200611 A/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.77 -0.3 1.79e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7124681 0.546 rs7941399 chr11:47890421 A/T cg20307385 chr11:47447363 PSMC3 0.47 6.86 0.35 3.42e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs921968 0.541 rs488767 chr2:219466860 G/T cg02176678 chr2:219576539 TTLL4 0.68 13.08 0.58 7.78e-32 Mean corpuscular hemoglobin concentration; LUSC cis rs354225 0.626 rs7608414 chr2:54844995 G/A cg26097391 chr2:54893211 SPTBN1 0.42 6.28 0.32 1.08e-9 Schizophrenia; LUSC cis rs701145 0.938 rs355773 chr3:154036657 A/G cg17054900 chr3:154042577 DHX36 -0.8 -8.8 -0.43 7.48e-17 Coronary artery disease; LUSC cis rs2050392 0.858 rs2250569 chr10:30698914 G/C cg18806716 chr10:30721971 MAP3K8 -0.48 -7.92 -0.4 3.57e-14 Inflammatory bowel disease; LUSC cis rs12541635 0.677 rs2880950 chr8:106983624 C/A cg10147462 chr8:107024639 NA 0.66 13.52 0.59 1.56e-33 Age of smoking initiation; LUSC cis rs2274273 0.712 rs6572999 chr14:55527374 T/C cg04306507 chr14:55594613 LGALS3 0.49 10.73 0.51 2.75e-23 Protein biomarker; LUSC cis rs3749237 1.000 rs2307021 chr3:49765483 C/G cg03060546 chr3:49711283 APEH 0.59 8.09 0.4 1.1e-14 Resting heart rate; LUSC cis rs4285028 0.948 rs13089878 chr3:121703895 T/C cg11130432 chr3:121712080 ILDR1 -0.66 -10.1 -0.48 4.03e-21 Multiple sclerosis; LUSC cis rs13315871 1.000 rs13317835 chr3:58383275 C/T cg12435725 chr3:58293450 RPP14 -0.73 -7.19 -0.37 4.4e-12 Cholesterol, total; LUSC cis rs10740039 0.810 rs6479720 chr10:62370693 C/T cg18175470 chr10:62150864 ANK3 -0.44 -6.58 -0.34 1.82e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1577917 0.958 rs12198061 chr6:86550985 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.99 -0.44 1.88e-17 Response to antipsychotic treatment; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg01373262 chr20:44034880 DBNDD2;SYS1-DBNDD2 0.42 6.09 0.32 3.1e-9 Calcium levels; LUSC cis rs4319547 0.737 rs10846921 chr12:122943376 G/T cg23029597 chr12:123009494 RSRC2 0.72 9.62 0.47 1.64e-19 Body mass index; LUSC cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg21427119 chr20:30132790 HM13 -0.37 -5.66 -0.3 3.31e-8 Mean corpuscular hemoglobin; LUSC cis rs2439831 0.867 rs933941 chr15:43632226 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.03 12.36 0.56 3.86e-29 Lung cancer in ever smokers; LUSC cis rs2652834 0.821 rs7174174 chr15:63372327 A/G cg05507819 chr15:63340323 TPM1 -0.51 -6.43 -0.33 4.51e-10 HDL cholesterol; LUSC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg05805236 chr11:65401703 PCNXL3 -0.37 -5.65 -0.3 3.5e-8 Breast cancer; LUSC cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -14.72 -0.63 3.66e-38 Chronic sinus infection; LUSC cis rs2486288 0.656 rs8039354 chr15:45551756 A/G cg09092052 chr15:45571596 NA -0.43 -6.06 -0.31 3.63e-9 Glomerular filtration rate; LUSC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg06634786 chr22:41940651 POLR3H -0.56 -6.54 -0.34 2.36e-10 Vitiligo; LUSC cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.89 -0.4 4.34e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg24675658 chr1:53192096 ZYG11B 0.57 8.83 0.44 5.83e-17 Monocyte count; LUSC trans rs4729127 1.000 rs78697521 chr7:94012938 G/C cg20086523 chr13:52378287 DHRS12 0.6 6.61 0.34 1.55e-10 Intelligence; LUSC cis rs7582180 0.817 rs1437967 chr2:100929072 C/G cg12002119 chr2:101014098 CHST10 0.35 5.91 0.31 8.66e-9 Intelligence (multi-trait analysis); LUSC cis rs727505 1.000 rs7795943 chr7:124483796 C/A cg23710748 chr7:124431027 NA -0.42 -7.67 -0.39 1.93e-13 Lewy body disease; LUSC trans rs71435601 0.574 rs570033 chr2:21399567 C/G cg20757404 chr19:378427 NA 0.39 6.15 0.32 2.15e-9 Cholesterol, total; LUSC cis rs9527 0.662 rs4919687 chr10:104595248 G/A cg04362960 chr10:104952993 NT5C2 0.64 9.2 0.45 3.9e-18 Arsenic metabolism; LUSC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg26335602 chr6:28129616 ZNF389 0.43 5.75 0.3 1.98e-8 Depression; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg04267008 chr7:1944627 MAD1L1 -0.58 -8.95 -0.44 2.59e-17 Bipolar disorder and schizophrenia; LUSC cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.88 0.35 2.88e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08109568 chr15:31115862 NA -0.6 -8.2 -0.41 5.28e-15 Huntington's disease progression; LUSC cis rs804280 0.509 rs4841639 chr8:11796093 A/T cg21775007 chr8:11205619 TDH 0.47 6.67 0.34 1.05e-10 Myopia (pathological); LUSC cis rs1395 0.961 rs4665965 chr2:27536380 C/T cg23587288 chr2:27483067 SLC30A3 0.29 5.69 0.3 2.79e-8 Blood metabolite levels; LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs73416724 1.000 rs77529883 chr6:43364634 C/G cg26312998 chr6:43337775 ZNF318 0.54 6.29 0.33 1.01e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4927850 0.666 rs4927853 chr3:195752053 G/C cg01181863 chr3:195395398 SDHAP2 -0.68 -9.28 -0.45 2.26e-18 Pancreatic cancer; LUSC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.16 15.5 0.65 3.26e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs701145 0.556 rs355771 chr3:154039385 G/C cg10247383 chr3:153839028 SGEF -0.46 -5.72 -0.3 2.33e-8 Coronary artery disease; LUSC cis rs11155671 0.530 rs9969044 chr6:150209204 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.74 -0.3 2.1e-8 Testicular germ cell tumor; LUSC trans rs7615952 0.736 rs9866347 chr3:125669925 C/T cg07211511 chr3:129823064 LOC729375 -1.06 -13.26 -0.59 1.53e-32 Blood pressure (smoking interaction); LUSC cis rs208520 0.690 rs3843513 chr6:66836797 A/G cg07460842 chr6:66804631 NA -1.14 -17.8 -0.7 2.53e-50 Exhaled nitric oxide output; LUSC cis rs554111 0.593 rs9426660 chr1:21520449 A/G cg01072550 chr1:21505969 NA -0.4 -6.0 -0.31 5.22e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs1577917 1.000 rs12213149 chr6:86668644 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.73 -0.43 1.23e-16 Response to antipsychotic treatment; LUSC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.62 0.5 6.6e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1775715 0.870 rs1615256 chr10:32254101 T/C cg04359828 chr10:32216031 ARHGAP12 0.38 6.24 0.32 1.33e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6076065 0.723 rs6137905 chr20:23340938 G/A cg11657817 chr20:23433608 CST11 0.43 8.03 0.4 1.7e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs2898681 0.618 rs79471207 chr4:53738524 C/T cg00791764 chr4:53727839 RASL11B 0.5 6.58 0.34 1.8e-10 Optic nerve measurement (cup area); LUSC trans rs11992162 0.560 rs13256329 chr8:11782214 G/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.76 -0.35 6.16e-11 Monocyte count; LUSC cis rs662735 0.515 rs535845 chr11:30839228 C/A cg14844989 chr11:31128820 NA 0.36 5.79 0.3 1.64e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg15423357 chr2:25149977 NA 0.4 7.83 0.39 6.45e-14 Body mass index; LUSC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg08219700 chr8:58056026 NA 0.45 5.83 0.3 1.28e-8 Developmental language disorder (linguistic errors); LUSC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs62432291 0.681 rs3003173 chr6:159665692 G/T cg14500486 chr6:159655392 FNDC1 -0.55 -5.92 -0.31 7.8e-9 Joint mobility (Beighton score); LUSC cis rs9436116 1 rs9436116 chr1:150454724 G/T cg15654264 chr1:150340011 RPRD2 0.45 7.24 0.37 3.13e-12 Morning vs. evening chronotype; LUSC cis rs1728785 1.000 rs1645927 chr16:68589300 T/G cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.4e-10 Ulcerative colitis; LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs912057 0.671 rs1024246 chr6:6743505 A/T cg06612196 chr6:6737390 NA 0.57 11.22 0.52 5.41e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg20933634 chr6:27740509 NA 0.4 5.87 0.31 1.06e-8 Parkinson's disease; LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg27588902 chr6:42928151 GNMT -0.29 -6.28 -0.32 1.07e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7833986 1.000 rs34230678 chr8:57083117 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.62 9.25 0.45 2.7e-18 Height; LUSC cis rs1538970 1.000 rs4520450 chr1:45834773 A/G cg06784218 chr1:46089804 CCDC17 0.32 5.79 0.3 1.59e-8 Platelet count; LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.93 -0.35 2.21e-11 Bipolar disorder and schizophrenia; LUSC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.91 -0.31 8.39e-9 Life satisfaction; LUSC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg12365402 chr11:9010492 NRIP3 0.45 8.29 0.41 2.81e-15 Hemoglobin concentration; LUSC cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg21535247 chr6:8435926 SLC35B3 0.58 8.99 0.44 1.87e-17 Motion sickness; LUSC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg02782426 chr3:40428986 ENTPD3 0.36 7.1 0.36 7.74e-12 Renal cell carcinoma; LUSC cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.59 -8.52 -0.42 5.59e-16 IgG glycosylation; LUSC cis rs9300255 0.664 rs12316131 chr12:123817796 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.37 5.65 0.3 3.41e-8 Neutrophil percentage of white cells; LUSC trans rs890100 0.644 rs11125631 chr2:56686389 C/A cg01657744 chr10:88471748 LDB3 0.44 5.97 0.31 6.13e-9 Gut microbiome composition (summer); LUSC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.49 0.46 4.59e-19 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.51 0.56 1.01e-29 Motion sickness; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg00431813 chr7:1051703 C7orf50 -0.47 -8.07 -0.4 1.24e-14 Longevity;Endometriosis; LUSC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.36 6.44 0.33 4.27e-10 Neutrophil percentage of white cells; LUSC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg13531842 chr10:38383804 ZNF37A -0.48 -7.44 -0.38 8.5e-13 Extrinsic epigenetic age acceleration; LUSC cis rs7312933 0.558 rs7965743 chr12:42736822 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.8 -0.35 4.88e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12220238 1.000 rs11000924 chr10:75972311 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.22 0.37 3.42e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg26335602 chr6:28129616 ZNF389 0.46 6.49 0.33 3.18e-10 Parkinson's disease; LUSC cis rs9796 0.835 rs3100807 chr15:41292206 G/A cg18705301 chr15:41695430 NDUFAF1 0.45 7.89 0.4 4.43e-14 Menopause (age at onset); LUSC cis rs1322639 0.668 rs9766666 chr6:169613541 G/T cg04662567 chr6:169592167 NA -0.4 -6.4 -0.33 5.13e-10 Pulse pressure; LUSC cis rs1801251 0.896 rs6719061 chr2:233695885 C/T cg25237894 chr2:233734115 C2orf82 -0.34 -6.29 -0.33 9.71e-10 Coronary artery disease; LUSC cis rs12216125 0.801 rs56107510 chr6:25987436 C/A cg16482183 chr6:26056742 HIST1H1C 0.58 7.98 0.4 2.42e-14 Iron status biomarkers; LUSC cis rs1519814 0.915 rs10808507 chr8:121166429 G/A cg22335954 chr8:121166405 COL14A1 -0.46 -6.12 -0.32 2.55e-9 Breast cancer; LUSC cis rs11122272 0.735 rs1416916 chr1:231533027 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.11 -0.48 3.98e-21 Hemoglobin concentration; LUSC cis rs9858542 0.537 rs9863142 chr3:49366741 C/G cg00383909 chr3:49044727 WDR6 0.57 6.89 0.35 2.73e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs672059 1.000 rs3118181 chr1:183166970 T/C ch.1.3577855R chr1:183094577 LAMC1 0.56 8.2 0.41 5.21e-15 Hypertriglyceridemia; LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg25036284 chr2:26402008 FAM59B 0.77 11.34 0.53 1.89e-25 Gut microbiome composition (summer); LUSC cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.28 -5.75 -0.3 2.06e-8 Schizophrenia; LUSC cis rs477692 0.673 rs1970197 chr10:131359588 C/T cg26102564 chr10:131424627 MGMT 0.38 5.79 0.3 1.62e-8 Response to temozolomide; LUSC cis rs2839186 0.934 rs17182538 chr21:47705673 C/A cg13126279 chr21:47581558 C21orf56 -0.41 -6.02 -0.31 4.72e-9 Testicular germ cell tumor; LUSC trans rs2018683 0.677 rs12540529 chr7:28969384 A/G cg19402173 chr7:128379420 CALU -0.45 -6.83 -0.35 4.11e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs10887741 0.646 rs4244979 chr10:89425507 A/C cg13926569 chr10:89418898 PAPSS2 0.32 6.64 0.34 1.23e-10 Exercise (leisure time); LUSC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg24690094 chr11:67383802 NA 0.44 8.72 0.43 1.29e-16 Mean corpuscular volume; LUSC cis rs6542838 0.641 rs6760065 chr2:99486318 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.69 -0.3 2.81e-8 Fear of minor pain; LUSC cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg02569458 chr12:86230093 RASSF9 0.53 8.55 0.42 4.35e-16 Major depressive disorder; LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.38 0.33 5.87e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2742417 1.000 rs2673025 chr3:45760483 A/G cg09608765 chr3:45636137 LIMD1 -0.37 -7.43 -0.38 9.37e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7590255 1.000 rs7590255 chr2:37990079 C/T cg23497611 chr2:37985316 NA 0.41 6.4 0.33 5.2400000000000005e-10 Nonsyndromic cleft lip with cleft palate; LUSC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.77 0.35 5.69e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7216064 1.000 rs3206817 chr17:65892834 A/G cg12091567 chr17:66097778 LOC651250 -0.71 -9.12 -0.45 7.15e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg13393036 chr8:95962371 TP53INP1 -0.46 -9.53 -0.46 3.41e-19 Type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11820517 chr11:43964150 LOC387763 0.73 6.19 0.32 1.74e-9 Cognitive performance; LUSC cis rs472402 0.540 rs2288445 chr5:6620092 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.41 -6.06 -0.31 3.63e-9 Response to amphetamines; LUSC cis rs4776059 0.550 rs11070906 chr15:52922525 C/G cg22715398 chr15:52968154 KIAA1370 -0.62 -6.94 -0.35 2.08e-11 Schizophrenia; LUSC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg10909506 chr17:38081995 ORMDL3 0.34 6.05 0.31 3.93e-9 Self-reported allergy; LUSC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg00745463 chr17:30367425 LRRC37B -0.8 -9.48 -0.46 4.95e-19 Hip circumference adjusted for BMI; LUSC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg18252515 chr7:66147081 NA 1.2 13.62 0.6 6.4e-34 Diabetic kidney disease; LUSC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg11965913 chr1:205819406 PM20D1 0.48 6.87 0.35 3.09e-11 Parkinson's disease; LUSC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg12564285 chr5:131593104 PDLIM4 0.43 7.83 0.39 6.4e-14 Breast cancer; LUSC trans rs60843830 0.662 rs6721594 chr2:305203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.6 -10.33 -0.49 6.72e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg09263875 chr16:632152 PIGQ 0.71 13.39 0.59 5.22e-33 Height; LUSC cis rs1775715 0.707 rs1541262 chr10:32179771 A/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.84 0.39 6.15e-14 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs17685 0.775 rs11761172 chr7:75761547 C/T cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4499344 0.730 rs421607 chr19:33104951 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.85 13.06 0.58 9.06e-32 Mean platelet volume; LUSC cis rs6088580 0.543 rs13042351 chr20:33238573 G/A cg07148914 chr20:33460835 GGT7 -0.52 -8.13 -0.41 8.68e-15 Glomerular filtration rate (creatinine); LUSC cis rs12410462 0.748 rs1495853 chr1:227657336 A/G cg23173402 chr1:227635558 NA -0.46 -5.73 -0.3 2.2e-8 Major depressive disorder; LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg09060608 chr5:178986726 RUFY1 -0.73 -14.1 -0.61 9.34e-36 Lung cancer; LUSC trans rs9650657 0.547 rs11250099 chr8:10818657 C/T cg15556689 chr8:8085844 FLJ10661 0.53 8.08 0.4 1.2e-14 Neuroticism; LUSC cis rs7267979 0.932 rs1541061 chr20:25521057 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.82 0.7 2.19e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg23758822 chr17:41437982 NA 1.03 20.02 0.74 3.9e-59 Menopause (age at onset); LUSC cis rs9467773 0.595 rs4320356 chr6:26423560 C/T cg05738196 chr6:26577821 NA -0.51 -7.53 -0.38 4.78e-13 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg20503657 chr10:835505 NA 0.97 13.49 0.59 2.05e-33 Eosinophil percentage of granulocytes; LUSC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg02782426 chr3:40428986 ENTPD3 0.38 7.4 0.38 1.15e-12 Renal cell carcinoma; LUSC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg10883421 chr6:151773342 RMND1;C6orf211 0.66 11.32 0.53 2.26e-25 Menarche (age at onset); LUSC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg05347473 chr6:146136440 FBXO30 -0.57 -9.82 -0.47 3.54e-20 Lobe attachment (rater-scored or self-reported); LUSC trans rs6869502 0.871 rs13354207 chr5:110151791 C/G cg07744993 chr5:89705938 CETN3 -0.41 -6.05 -0.31 3.83e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs8141529 0.509 rs12628211 chr22:29239250 T/C cg15103426 chr22:29168792 CCDC117 0.49 6.47 0.33 3.39e-10 Lymphocyte counts; LUSC cis rs1577917 0.771 rs9362239 chr6:86429263 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 10.41 0.5 3.53e-22 Response to antipsychotic treatment; LUSC trans rs11098499 0.754 rs10212775 chr4:120239244 G/C cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -14.72 -0.63 3.66e-38 Chronic sinus infection; LUSC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg17376030 chr22:41985996 PMM1 -0.46 -5.88 -0.31 9.9e-9 Vitiligo; LUSC cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.44 0.33 4.16e-10 Mean platelet volume; LUSC cis rs9325144 0.513 rs7977596 chr12:38649067 C/A cg26384229 chr12:38710491 ALG10B -0.66 -10.28 -0.49 1.02e-21 Morning vs. evening chronotype; LUSC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg05347473 chr6:146136440 FBXO30 0.65 11.4 0.53 1.16e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs7917772 0.507 rs2778036 chr10:104485725 G/A cg22532475 chr10:104410764 TRIM8 -0.31 -6.05 -0.31 3.83e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg18904891 chr8:8559673 CLDN23 0.58 8.11 0.41 9.67e-15 Obesity-related traits; LUSC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg24562669 chr7:97807699 LMTK2 0.38 6.54 0.34 2.37e-10 Prostate cancer (SNP x SNP interaction); LUSC trans rs13011075 0.919 rs1542136 chr2:68620930 A/C cg14221825 chr19:46271408 SIX5 -0.44 -6.2 -0.32 1.7e-9 Mean corpuscular volume; LUSC cis rs7267979 1.000 rs1888997 chr20:25298988 G/A cg03522245 chr20:25566470 NINL -0.36 -5.77 -0.3 1.85e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg06634786 chr22:41940651 POLR3H 0.48 5.71 0.3 2.46e-8 Vitiligo; LUSC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC trans rs6952808 0.624 rs60137119 chr7:2083664 A/G cg04565464 chr8:145669602 NFKBIL2 0.41 6.58 0.34 1.83e-10 Bipolar disorder and schizophrenia; LUSC cis rs9814567 1.000 rs9289475 chr3:134236459 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.7 -0.6 3.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4474465 1.000 rs11602360 chr11:78179336 A/G cg27205649 chr11:78285834 NARS2 0.48 5.66 0.3 3.18e-8 Alzheimer's disease (survival time); LUSC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg22800045 chr5:56110881 MAP3K1 -0.79 -9.86 -0.47 2.76e-20 Initial pursuit acceleration; LUSC cis rs950776 0.518 rs2869055 chr15:78822388 G/C cg06917634 chr15:78832804 PSMA4 -0.8 -14.01 -0.61 2.11e-35 Sudden cardiac arrest; LUSC cis rs1865760 0.566 rs3752419 chr6:26027433 C/T cg16482183 chr6:26056742 HIST1H1C 0.49 7.21 0.37 3.84e-12 Height; LUSC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs34638657 0.732 rs10514532 chr16:82200337 C/T cg09439754 chr16:82129088 HSD17B2 0.39 6.62 0.34 1.41e-10 Lung adenocarcinoma; LUSC cis rs3824867 0.920 rs80241400 chr11:47453828 T/C cg20307385 chr11:47447363 PSMC3 -0.65 -9.65 -0.47 1.35e-19 Mean corpuscular hemoglobin; LUSC cis rs72634258 0.554 rs17374781 chr1:7919363 A/G cg26816564 chr1:7831052 VAMP3 -0.7 -9.71 -0.47 8.22e-20 Inflammatory bowel disease; LUSC cis rs78456975 1.000 rs13400784 chr2:1564473 T/A cg12573674 chr2:1569213 NA -0.56 -6.18 -0.32 1.86e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.84 -0.54 3.05e-27 Chronic sinus infection; LUSC cis rs6740322 1.000 rs4128209 chr2:43554729 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.46 -6.5 -0.34 2.88e-10 Coronary artery disease; LUSC cis rs939574 0.858 rs2891733 chr2:220135208 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.81 7.05 0.36 1.04e-11 Platelet distribution width; LUSC cis rs1018836 0.892 rs11776824 chr8:91553256 T/C cg16814680 chr8:91681699 NA -0.7 -11.5 -0.53 5.21e-26 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg26408565 chr15:76604113 ETFA 0.48 7.62 0.38 2.71e-13 Blood metabolite levels; LUSC cis rs7267979 1.000 rs6050617 chr20:25421648 C/T cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2180341 0.576 rs2057224 chr6:127624414 C/G cg24812749 chr6:127587940 RNF146 0.65 9.75 0.47 6.4e-20 Breast cancer; LUSC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg06238570 chr21:40685208 BRWD1 0.47 7.25 0.37 2.94e-12 Cognitive function; LUSC cis rs1595825 0.891 rs892512 chr2:198905910 C/A cg10547527 chr2:198650123 BOLL -0.47 -5.87 -0.31 1.07e-8 Ulcerative colitis; LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg27170947 chr2:26402098 FAM59B 0.63 8.84 0.44 5.69e-17 Gut microbiome composition (summer); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg00092287 chr2:152146295 NMI 0.41 5.96 0.31 6.58e-9 Mosquito bite size; LUSC cis rs472402 0.580 rs8192186 chr5:6652009 G/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.45 -6.6 -0.34 1.65e-10 Response to amphetamines; LUSC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg08847533 chr14:75593920 NEK9 0.51 7.46 0.38 7.67e-13 Caffeine consumption; LUSC trans rs853679 0.607 rs67340775 chr6:28304384 A/C cg06606381 chr12:133084897 FBRSL1 -1.04 -9.08 -0.44 9.35e-18 Depression; LUSC cis rs6967385 0.934 rs2253353 chr7:12370657 A/G cg06484146 chr7:12443880 VWDE 0.42 6.15 0.32 2.26e-9 Response to taxane treatment (placlitaxel); LUSC cis rs2777491 1.000 rs316605 chr15:41771591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.29 -0.59 1.24e-32 Ulcerative colitis; LUSC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg17533458 chr5:92956826 FAM172A;MIR2277 0.57 6.14 0.32 2.4e-9 Diabetic retinopathy; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg26304593 chr6:42947056 PEX6 -0.49 -7.34 -0.37 1.63e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs8062405 1.000 rs62036616 chr16:28826307 A/G cg05966235 chr16:28915196 ATP2A1 0.33 5.8 0.3 1.54e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2806561 0.929 rs627304 chr1:23537555 A/G cg19743168 chr1:23544995 NA 0.47 10.15 0.49 2.88e-21 Height; LUSC cis rs7312933 0.702 rs10785333 chr12:42586470 A/G cg01256987 chr12:42539512 GXYLT1 0.46 8.46 0.42 8.77e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs979233 0.502 rs276266 chr5:42068610 G/C cg07010552 chr17:7358735 CHRNB1 -0.41 -5.98 -0.31 5.65e-9 Systemic lupus erythematosus; LUSC cis rs9644630 0.870 rs4244453 chr8:19359711 G/A cg01280390 chr8:19363452 CSGALNACT1 0.36 6.92 0.35 2.26e-11 Oropharynx cancer; LUSC trans rs877282 1.000 rs12219807 chr10:772870 A/C cg22713356 chr15:30763199 NA 1.09 15.15 0.64 7.93e-40 Uric acid levels; LUSC cis rs3741151 0.773 rs7934218 chr11:73206729 C/T cg17517138 chr11:73019481 ARHGEF17 0.83 7.71 0.39 1.48e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7216064 0.765 rs6504550 chr17:65894542 A/G cg12091567 chr17:66097778 LOC651250 -0.64 -9.16 -0.45 5.35e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2658782 1.000 rs2658781 chr11:93166368 C/T cg15737290 chr11:93063684 CCDC67 -0.65 -8.16 -0.41 7.04e-15 Pulmonary function decline; LUSC cis rs13242816 1.000 rs13235720 chr7:116113663 T/C cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs4595586 0.545 rs1400284 chr12:39400419 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.06 0.36 9.57e-12 Morning vs. evening chronotype; LUSC cis rs7072216 0.763 rs6584205 chr10:100173806 C/T cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg06212747 chr3:49208901 KLHDC8B 0.44 6.01 0.31 4.85e-9 Parkinson's disease; LUSC cis rs17826219 0.636 rs79565452 chr17:29142841 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Body mass index; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg18230493 chr5:56204884 C5orf35 -0.55 -8.91 -0.44 3.36e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs4363385 0.574 rs6671520 chr1:152944156 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.76 -0.3 1.87e-8 Inflammatory skin disease; LUSC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg20608306 chr11:116969690 SIK3 0.36 6.82 0.35 4.26e-11 Blood protein levels; LUSC trans rs11743006 1.000 rs76245514 chr5:136523315 C/A cg07379741 chr17:7311030 NLGN2 0.42 6.01 0.31 4.9e-9 Mathematical ability; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11635074 chr17:40925442 VPS25 -0.41 -6.14 -0.32 2.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4737010 0.570 rs2111804 chr8:41644266 A/T cg17182837 chr8:41585554 ANK1 -0.36 -6.62 -0.34 1.4e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs7586879 0.609 rs7608976 chr2:25075281 G/A cg01884057 chr2:25150051 NA 0.4 8.99 0.44 1.87e-17 Body mass index; LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 6.28 0.32 1.08e-9 Bipolar disorder; LUSC cis rs965469 1.000 rs6037526 chr20:3251248 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -6.28 -0.33 1.04e-9 IFN-related cytopenia; LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg23788917 chr6:8435910 SLC35B3 0.5 7.31 0.37 2.03e-12 Motion sickness; LUSC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg18876405 chr7:65276391 NA -0.7 -12.66 -0.57 2.88e-30 Aortic root size; LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg13395646 chr4:1353034 KIAA1530 -0.62 -9.58 -0.46 2.23e-19 Obesity-related traits; LUSC cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg22875332 chr1:76189707 ACADM -0.42 -6.26 -0.32 1.16e-9 Daytime sleep phenotypes; LUSC cis rs6714710 0.603 rs13034929 chr2:98402772 G/C cg26665480 chr2:98280029 ACTR1B 0.63 9.1 0.45 8.41e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs10186029 0.680 rs13007271 chr2:213937767 G/C cg08319019 chr2:214017104 IKZF2 0.55 8.02 0.4 1.75e-14 Systemic sclerosis; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.79 0.6 1.44e-34 Platelet count; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC trans rs7647973 0.710 rs11130207 chr3:49611666 T/G cg21659725 chr3:3221576 CRBN -0.71 -7.82 -0.39 7.08e-14 Menarche (age at onset); LUSC cis rs13315871 0.790 rs13071148 chr3:58310838 A/C cg20936604 chr3:58311152 NA -0.77 -7.11 -0.36 7.27e-12 Cholesterol, total; LUSC cis rs72792276 1.000 rs72794379 chr5:127464965 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.92 7.84 0.39 5.98e-14 Red cell distribution width; LUSC cis rs977987 0.806 rs4887823 chr16:75433074 T/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.77 -0.35 5.95e-11 Dupuytren's disease; LUSC cis rs2625529 0.617 rs11633167 chr15:72179178 C/A cg16672083 chr15:72433130 SENP8 0.5 8.07 0.4 1.26e-14 Red blood cell count; LUSC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg09365446 chr1:150670422 GOLPH3L -0.39 -5.75 -0.3 1.99e-8 Tonsillectomy; LUSC cis rs9467711 0.591 rs10484433 chr6:26030492 G/T cg16898833 chr6:26189333 HIST1H4D 0.69 6.52 0.34 2.55e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9473147 0.543 rs1004173 chr6:47445017 C/T cg12968598 chr6:47444699 CD2AP 0.54 8.18 0.41 6.18e-15 Platelet distribution width;Mean platelet volume; LUSC trans rs7647973 0.667 rs6446286 chr3:49681704 A/G cg21659725 chr3:3221576 CRBN -0.68 -7.85 -0.39 5.77e-14 Menarche (age at onset); LUSC cis rs7927771 0.864 rs4752838 chr11:47466006 G/A cg18512352 chr11:47633146 NA -0.48 -9.64 -0.47 1.49e-19 Subjective well-being; LUSC trans rs61931739 0.635 rs1852224 chr12:33963080 A/C cg13010199 chr12:38710504 ALG10B 0.4 6.03 0.31 4.34e-9 Morning vs. evening chronotype; LUSC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg06618935 chr21:46677482 NA 0.38 7.01 0.36 1.33e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4474465 0.833 rs7934912 chr11:78218556 A/T cg27205649 chr11:78285834 NARS2 0.5 5.77 0.3 1.8e-8 Alzheimer's disease (survival time); LUSC cis rs6835098 0.887 rs12644699 chr4:174142874 A/G cg27433088 chr4:174089019 GALNT7 -0.4 -6.13 -0.32 2.51e-9 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg20891283 chr12:69753455 YEATS4 0.91 17.45 0.69 6.11e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs1983891 0.955 rs4714487 chr6:41547312 T/C cg20194872 chr6:41519635 FOXP4 0.36 6.37 0.33 6.21e-10 Prostate cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12882476 chr5:114632168 CCDC112 0.7 6.21 0.32 1.59e-9 Cognitive performance; LUSC cis rs1775715 0.677 rs2491272 chr10:32186783 A/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.65 0.34 1.22e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg27284194 chr4:1044797 NA 0.35 5.78 0.3 1.74e-8 Obesity-related traits; LUSC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 12.98 0.58 1.77e-31 Hip circumference adjusted for BMI; LUSC trans rs72674100 1.000 rs28575922 chr4:97974891 C/A cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.55 0.46 2.89e-19 Mean platelet volume; LUSC cis rs11711311 0.747 rs7638449 chr3:113343646 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -5.92 -0.31 8.18e-9 IgG glycosylation; LUSC cis rs9326248 0.727 rs4938347 chr11:117021759 T/A cg26566898 chr11:117069891 TAGLN 0.37 5.87 0.31 1.04e-8 Blood protein levels; LUSC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg12463550 chr7:65579703 CRCP -0.53 -7.72 -0.39 1.4e-13 Aortic root size; LUSC cis rs3806843 0.933 rs2879087 chr5:140188575 G/C cg19875535 chr5:140030758 IK 0.47 7.52 0.38 5.19e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs6494488 0.500 rs72744709 chr15:65013210 T/C cg08069370 chr15:64387884 SNX1 -0.66 -6.09 -0.32 3.06e-9 Coronary artery disease; LUSC trans rs6952808 0.895 rs12669518 chr7:1921429 G/C cg04565464 chr8:145669602 NFKBIL2 0.36 5.96 0.31 6.58e-9 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg07936489 chr17:37558343 FBXL20 0.71 9.7 0.47 9.15e-20 Glomerular filtration rate (creatinine); LUSC trans rs9291683 0.620 rs717615 chr4:10104670 C/T cg26043149 chr18:55253948 FECH 0.54 8.02 0.4 1.82e-14 Bone mineral density; LUSC cis rs6087990 0.735 rs2424914 chr20:31374520 A/G cg13636640 chr20:31349939 DNMT3B 0.91 18.44 0.71 7.17e-53 Ulcerative colitis; LUSC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg15369054 chr17:80825471 TBCD -0.36 -6.01 -0.31 4.8e-9 Breast cancer; LUSC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg23583168 chr7:148888333 NA -0.84 -14.83 -0.63 1.35e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7216064 1.000 rs7214758 chr17:65880538 T/C cg12091567 chr17:66097778 LOC651250 -0.76 -9.64 -0.47 1.51e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg22834771 chr12:69754056 YEATS4 -0.53 -8.07 -0.4 1.31e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs847577 0.748 rs940431 chr7:97716495 C/T cg24562669 chr7:97807699 LMTK2 0.43 7.32 0.37 1.86e-12 Breast cancer; LUSC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg15369054 chr17:80825471 TBCD -0.66 -11.0 -0.52 3.09e-24 Breast cancer; LUSC cis rs11583043 0.874 rs6577222 chr1:101420502 C/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.2 0.32 1.71e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs540254 0.619 rs4656932 chr1:160779495 C/T cg20255094 chr1:160771763 LY9 0.56 7.17 0.37 4.84e-12 Blood protein levels; LUSC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg05585544 chr11:47624801 NA 0.41 7.24 0.37 3.04e-12 Subjective well-being; LUSC trans rs13011075 0.878 rs13430654 chr2:68587710 C/G cg14221825 chr19:46271408 SIX5 0.42 5.96 0.31 6.37e-9 Mean corpuscular volume; LUSC cis rs4631830 0.863 rs4935162 chr10:51525699 C/G cg16070123 chr10:51489643 NA -0.53 -8.54 -0.42 4.82e-16 Prostate-specific antigen levels; LUSC trans rs9860340 0.690 rs7619452 chr3:87633703 C/G cg03644585 chr7:884825 UNC84A 0.42 6.09 0.32 3.17e-9 Electroencephalographic traits in alcoholism; LUSC cis rs4654899 0.897 rs12121807 chr1:21069129 A/C cg01072550 chr1:21505969 NA -0.46 -6.92 -0.35 2.25e-11 Superior frontal gyrus grey matter volume; LUSC cis rs360798 0.553 rs11682530 chr2:63073194 C/T cg17519650 chr2:63277830 OTX1 -0.52 -7.34 -0.37 1.65e-12 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05935283 chr3:190231667 IL1RAP -0.44 -6.56 -0.34 2.04e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2363709 0.764 rs9832823 chr3:67418273 C/T cg23062198 chr2:14774063 FAM84A -0.54 -5.98 -0.31 5.77e-9 IgE levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10122766 chr19:2977386 TLE6 -0.4 -6.12 -0.32 2.59e-9 Electrocardiographic conduction measures; LUSC cis rs1348850 0.574 rs13431105 chr2:178434674 A/G cg22681709 chr2:178499509 PDE11A -0.41 -5.68 -0.3 2.91e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs926938 0.527 rs58658580 chr1:115539726 A/G cg12756093 chr1:115239321 AMPD1 0.44 6.65 0.34 1.17e-10 Autism; LUSC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg03676636 chr4:99064102 C4orf37 0.33 7.23 0.37 3.25e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7618501 1.000 rs11130219 chr3:49752427 C/T cg24110177 chr3:50126178 RBM5 0.4 6.46 0.33 3.73e-10 Intelligence (multi-trait analysis); LUSC trans rs11782517 0.881 rs7845806 chr8:10110188 C/T cg15556689 chr8:8085844 FLJ10661 0.5 6.15 0.32 2.2e-9 Nose size; LUSC cis rs136211 0.577 rs9607339 chr22:36768932 G/T cg16924664 chr22:36878180 TXN2 0.41 6.22 0.32 1.52e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg18904891 chr8:8559673 CLDN23 0.38 5.94 0.31 7.25e-9 Mood instability; LUSC cis rs7818345 0.935 rs6983973 chr8:19287867 T/C cg11303988 chr8:19266685 CSGALNACT1 0.36 6.96 0.36 1.8e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2307022 0.586 rs3785123 chr16:68386581 C/T cg02226672 chr16:68398533 SMPD3 0.3 5.82 0.3 1.42e-8 Body mass index; LUSC cis rs317689 0.600 rs478188 chr12:69639215 A/G cg20891283 chr12:69753455 YEATS4 0.44 5.82 0.3 1.38e-8 Response to diuretic therapy; LUSC cis rs1712517 0.838 rs6584543 chr10:104997014 G/A cg05636881 chr10:105038444 INA -0.4 -6.65 -0.34 1.22e-10 Migraine; LUSC cis rs9487051 0.735 rs1341272 chr6:109507533 C/T cg01475377 chr6:109611718 NA 0.35 6.04 0.31 4.02e-9 Reticulocyte fraction of red cells; LUSC trans rs4332037 0.950 rs10267593 chr7:1937261 G/A cg11693508 chr17:37793320 STARD3 0.59 7.59 0.38 3.2e-13 Bipolar disorder; LUSC cis rs1577917 0.958 rs12665542 chr6:86544443 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.74 -0.35 6.92e-11 Response to antipsychotic treatment; LUSC cis rs3816788 0.792 rs7013323 chr8:21869024 C/G cg17168535 chr8:21777572 XPO7 0.81 13.03 0.58 1.19e-31 Lung cancer in ever smokers; LUSC cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg17063962 chr7:91808500 NA 0.57 8.81 0.43 7.14e-17 Breast cancer; LUSC cis rs1215050 0.740 rs6854802 chr4:99065480 A/C cg05340658 chr4:99064831 C4orf37 0.45 7.3 0.37 2.09e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg12016809 chr21:47604291 C21orf56 0.46 6.75 0.35 6.59e-11 Testicular germ cell tumor; LUSC cis rs1124376 1.000 rs9819739 chr3:20140760 G/A cg05072819 chr3:20081367 KAT2B 0.64 7.37 0.37 1.39e-12 Bipolar disorder and schizophrenia; LUSC cis rs9646944 0.501 rs3732127 chr2:103013750 G/C cg20060108 chr2:102954350 IL1RL1 0.48 6.51 0.34 2.73e-10 Blood protein levels; LUSC cis rs8072100 0.846 rs6503796 chr17:45765249 T/C cg08085267 chr17:45401833 C17orf57 -0.46 -6.96 -0.36 1.82e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.06 -0.4 1.35e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9399401 0.921 rs9373346 chr6:142746992 G/A cg03128060 chr6:142623767 GPR126 0.34 6.22 0.32 1.51e-9 Chronic obstructive pulmonary disease; LUSC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg04369109 chr6:150039330 LATS1 -0.55 -8.09 -0.4 1.09e-14 Lung cancer; LUSC cis rs3820928 0.874 rs7423610 chr2:227836262 A/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.42 -0.38 9.97e-13 Pulmonary function; LUSC cis rs7131987 0.622 rs7294598 chr12:29531989 A/C cg09582351 chr12:29534625 ERGIC2 0.33 6.58 0.34 1.79e-10 QT interval; LUSC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.38 7.37 0.37 1.32e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs2180341 0.618 rs11961994 chr6:127649350 A/G cg27446573 chr6:127587934 RNF146 -0.63 -10.23 -0.49 1.55e-21 Breast cancer; LUSC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg11764359 chr7:65958608 NA 0.71 10.68 0.5 4.16e-23 Aortic root size; LUSC cis rs8044995 0.706 rs111948678 chr16:68255959 G/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.02 -0.36 1.24e-11 Schizophrenia; LUSC cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg18876405 chr7:65276391 NA 0.55 8.81 0.43 6.74e-17 Aortic root size; LUSC cis rs7927592 0.956 rs7944870 chr11:68309108 C/G cg20283391 chr11:68216788 NA -0.57 -8.2 -0.41 5.27e-15 Total body bone mineral density; LUSC cis rs4363385 0.747 rs1577962 chr1:152962013 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.59 -0.38 3.15e-13 Inflammatory skin disease; LUSC cis rs10761482 0.813 rs4948411 chr10:62116075 T/G cg18175470 chr10:62150864 ANK3 -0.53 -7.5 -0.38 5.65e-13 Schizophrenia; LUSC trans rs1493916 0.905 rs34910379 chr18:31400047 A/G cg27147174 chr7:100797783 AP1S1 -0.63 -10.05 -0.48 6.29e-21 Life satisfaction; LUSC cis rs2742417 1.000 rs2742438 chr3:45743390 G/T cg04837898 chr3:45731254 SACM1L -0.35 -5.66 -0.3 3.28e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs3764021 0.870 rs2401395 chr12:9879540 A/C cg20894963 chr12:9885564 CLECL1 0.34 6.85 0.35 3.58e-11 Type 1 diabetes; LUSC cis rs7582180 0.967 rs7595580 chr2:100896964 A/G cg08017756 chr2:100939284 LONRF2 -0.36 -5.98 -0.31 5.76e-9 Intelligence (multi-trait analysis); LUSC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.95 0.36 1.97e-11 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03399598 chr4:174091002 GALNT7 0.44 6.49 0.33 3.16e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18815388 chr7:100291905 NA 0.36 6.09 0.32 3.15e-9 Asthma; LUSC cis rs137603 0.602 rs9611146 chr22:39718120 G/T cg17798944 chr22:39715225 SNORD43;RPL3 -0.52 -8.27 -0.41 3.22e-15 Primary biliary cholangitis; LUSC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg24562669 chr7:97807699 LMTK2 0.35 6.12 0.32 2.68e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11890956 chr21:40555474 PSMG1 0.74 11.98 0.55 9.17e-28 Cognitive function; LUSC cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.46e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7267979 1.000 rs2482940 chr20:25349830 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.51 -0.34 2.81e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs1953600 0.870 rs2573370 chr10:81951366 C/T cg00277334 chr10:82204260 NA 0.45 7.08 0.36 8.35e-12 Sarcoidosis; LUSC cis rs2354432 0.556 rs59180647 chr1:146772062 C/T cg25205988 chr1:146714368 CHD1L -1.02 -9.56 -0.46 2.71e-19 Mitochondrial DNA levels; LUSC cis rs4776059 1.000 rs62023352 chr15:52889448 T/C cg22715398 chr15:52968154 KIAA1370 -0.71 -10.09 -0.48 4.56e-21 Schizophrenia; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.7 0.39 1.61e-13 Prudent dietary pattern; LUSC cis rs2235642 0.750 rs1894649 chr16:1657284 C/G cg26528668 chr16:1614120 IFT140 0.41 7.02 0.36 1.21e-11 Coronary artery disease; LUSC cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.83e-11 Intelligence (multi-trait analysis); LUSC cis rs7172677 0.731 rs1108059 chr15:75338890 A/C cg14664628 chr15:75095509 CSK 0.52 6.82 0.35 4.35e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg18681998 chr4:17616180 MED28 -0.87 -15.39 -0.64 8.93e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg00166722 chr3:10149974 C3orf24 0.53 7.59 0.38 3.31e-13 Alzheimer's disease; LUSC cis rs9303401 0.659 rs7216648 chr17:56790858 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg21251018 chr6:28226885 NKAPL 0.31 5.83 0.3 1.31e-8 Cardiac Troponin-T levels; LUSC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg21724239 chr8:58056113 NA 0.54 6.86 0.35 3.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13911393 chr17:37894944 GRB7 -0.45 -6.38 -0.33 5.78e-10 Hepatitis; LUSC cis rs8078723 1.000 rs1042658 chr17:38173902 C/T cg17467752 chr17:38218738 THRA 0.78 12.57 0.57 5.92e-30 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs5769707 0.521 rs739244 chr22:50060158 A/G cg20744362 chr22:50050164 C22orf34 0.36 6.65 0.34 1.19e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11122272 0.735 rs2790885 chr1:231529925 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.25 -0.49 1.28e-21 Hemoglobin concentration; LUSC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg00784671 chr22:46762841 CELSR1 -0.49 -6.7 -0.34 8.75e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg08109568 chr15:31115862 NA -0.74 -11.04 -0.52 2.25e-24 Huntington's disease progression; LUSC cis rs3820928 1.000 rs11686072 chr2:227777493 A/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.8e-14 Pulmonary function; LUSC cis rs12200782 0.505 rs7765920 chr6:26514771 C/T cg11502198 chr6:26597334 ABT1 0.88 10.88 0.51 8.1e-24 Small cell lung carcinoma; LUSC cis rs7617773 0.817 rs6796490 chr3:48237104 A/C cg20734569 chr3:48348370 SPINK8 -0.41 -7.44 -0.38 8.58e-13 Coronary artery disease; LUSC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg08859206 chr1:53392774 SCP2 0.52 9.02 0.44 1.54e-17 Monocyte count; LUSC cis rs4805272 0.512 rs17772319 chr19:29343064 T/A cg12667521 chr19:29218732 NA 0.53 6.14 0.32 2.32e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg22782873 chr19:19639568 YJEFN3 -0.5 -6.17 -0.32 2.01e-9 Bipolar disorder; LUSC trans rs7939886 0.920 rs11227463 chr11:55955447 C/T cg03929089 chr4:120376271 NA 0.82 6.22 0.32 1.53e-9 Myopia (pathological); LUSC cis rs2882667 0.690 rs825669 chr5:138066947 A/T cg04439458 chr5:138467593 SIL1 0.36 6.99 0.36 1.47e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs4722551 0.507 rs10239682 chr7:26019353 G/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.41 -6.3 -0.33 9.34e-10 LDL cholesterol;Cholesterol, total;Triglycerides; LUSC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11644478 chr21:40555479 PSMG1 -0.84 -15.18 -0.64 5.82e-40 Cognitive function; LUSC cis rs6920965 0.507 rs12203025 chr6:126192034 C/T cg10911889 chr6:126070802 HEY2 0.39 5.65 0.3 3.36e-8 High light scatter reticulocyte count; LUSC cis rs10792830 0.741 rs541674 chr11:85737502 A/G cg07180834 chr11:85838833 NA -0.3 -5.7 -0.3 2.63e-8 Psychosis and Alzheimer's disease; LUSC cis rs2273669 0.504 rs77107907 chr6:109436345 C/A cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg15556689 chr8:8085844 FLJ10661 0.67 10.99 0.52 3.32e-24 Mood instability; LUSC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg19077165 chr18:44547161 KATNAL2 -0.42 -6.3 -0.33 9.64e-10 Personality dimensions; LUSC cis rs11098499 0.526 rs10026625 chr4:120280136 T/C cg24375607 chr4:120327624 NA 0.51 7.68 0.39 1.8e-13 Corneal astigmatism; LUSC cis rs17685 0.753 rs1104878 chr7:75685593 G/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.68 -0.39 1.74e-13 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs2243480 0.803 rs160649 chr7:65543199 C/T cg10756647 chr7:56101905 PSPH 0.87 8.88 0.44 4.33e-17 Diabetic kidney disease; LUSC cis rs3007168 1.000 rs2999360 chr14:51605429 G/A cg23942311 chr14:51606299 NA 0.37 6.02 0.31 4.5e-9 Cancer; LUSC cis rs7267979 1.000 rs6107046 chr20:25442049 G/A cg08601574 chr20:25228251 PYGB 0.43 6.57 0.34 1.94e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2839186 0.900 rs2839200 chr21:47709095 C/T cg13126279 chr21:47581558 C21orf56 -0.42 -6.11 -0.32 2.7e-9 Testicular germ cell tumor; LUSC cis rs2806561 0.894 rs598438 chr1:23531563 C/T cg19743168 chr1:23544995 NA 0.48 10.36 0.49 5.47e-22 Height; LUSC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg15485101 chr11:133734466 NA 0.42 7.57 0.38 3.78e-13 Childhood ear infection; LUSC cis rs2273669 0.667 rs11153156 chr6:109365911 C/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC trans rs2243480 1.000 rs431076 chr7:65600320 A/C cg10756647 chr7:56101905 PSPH 0.89 8.94 0.44 2.61e-17 Diabetic kidney disease; LUSC trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.33 0.41 2.17e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs11711311 1.000 rs9809850 chr3:113429010 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.64 0.34 1.25e-10 IgG glycosylation; LUSC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12667521 chr19:29218732 NA 0.63 9.05 0.44 1.18e-17 Methadone dose in opioid dependence; LUSC cis rs2219968 1.000 rs28551624 chr8:78957333 A/G cg00738934 chr8:78996279 NA 0.38 6.97 0.36 1.67e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7296418 0.738 rs1568428 chr12:123738876 A/G cg00376283 chr12:123451042 ABCB9 -0.68 -10.5 -0.5 1.76e-22 Platelet count; LUSC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg19920283 chr7:105172520 RINT1 0.58 6.25 0.32 1.25e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7568458 0.875 rs2044474 chr2:85758790 G/A cg17127132 chr2:85788382 GGCX 0.47 7.66 0.39 2e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2075371 0.501 rs1613152 chr7:134019837 A/G cg20476274 chr7:133979776 SLC35B4 0.68 11.23 0.52 4.9e-25 Mean platelet volume; LUSC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.77 0.35 5.72e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg13395646 chr4:1353034 KIAA1530 -0.56 -8.38 -0.42 1.54e-15 Longevity; LUSC trans rs61931739 0.517 rs10772139 chr12:34186178 A/T cg26384229 chr12:38710491 ALG10B 0.74 11.9 0.55 1.78e-27 Morning vs. evening chronotype; LUSC cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg18132916 chr6:79620363 NA -0.39 -5.98 -0.31 5.66e-9 Intelligence (multi-trait analysis); LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg08859206 chr1:53392774 SCP2 -0.68 -13.03 -0.58 1.13e-31 Monocyte count; LUSC cis rs208520 0.661 rs1100950 chr6:66827285 A/C cg07460842 chr6:66804631 NA -1.15 -18.3 -0.71 2.71e-52 Exhaled nitric oxide output; LUSC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg26913058 chr16:419975 MRPL28 -0.33 -5.66 -0.3 3.25e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs977987 0.806 rs2161684 chr16:75479153 T/C cg03315344 chr16:75512273 CHST6 0.5 9.67 0.47 1.17e-19 Dupuytren's disease; LUSC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs1832871 1.000 rs827857 chr6:158706497 C/T cg07165851 chr6:158734300 TULP4 0.37 6.47 0.33 3.49e-10 Height; LUSC cis rs2455601 0.786 rs10279 chr11:8969309 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -6.67 -0.34 1.04e-10 Schizophrenia; LUSC cis rs9457247 0.905 rs444210 chr6:167390242 A/G cg25258033 chr6:167368657 RNASET2 0.43 7.15 0.36 5.49e-12 Crohn's disease; LUSC cis rs2235544 0.565 rs633697 chr1:54468760 A/G cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.76 -0.35 6.24e-11 Total body bone mineral density; LUSC cis rs7903847 0.619 rs10786336 chr10:99134953 A/C cg06359132 chr10:99160096 RRP12 -0.24 -5.65 -0.3 3.39e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs7617773 0.780 rs11714176 chr3:48360862 C/T cg20734569 chr3:48348370 SPINK8 -0.47 -7.93 -0.4 3.4e-14 Coronary artery disease; LUSC cis rs4409675 0.912 rs11247730 chr1:28270737 A/G cg23691781 chr1:28212827 C1orf38 -0.28 -5.84 -0.3 1.22e-8 Corneal astigmatism; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg07677032 chr17:61819896 STRADA -0.51 -8.49 -0.42 6.65e-16 Prudent dietary pattern; LUSC cis rs7829975 0.606 rs891570 chr8:8794454 G/A cg15556689 chr8:8085844 FLJ10661 -0.61 -10.3 -0.49 8.92e-22 Mood instability; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg10360139 chr7:1886902 MAD1L1 -0.46 -7.08 -0.36 8.61e-12 Bipolar disorder and schizophrenia; LUSC cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg04455712 chr21:45112962 RRP1B 0.46 8.88 0.44 4.26e-17 Mean corpuscular volume; LUSC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg00784671 chr22:46762841 CELSR1 -0.47 -6.31 -0.33 8.66e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg07703079 chr11:430292 ANO9 0.66 6.75 0.35 6.51e-11 Body mass index; LUSC cis rs7267979 0.934 rs2500399 chr20:25354694 T/G cg08601574 chr20:25228251 PYGB -0.43 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11997175 0.574 rs4520125 chr8:33648628 C/T ch.8.33884649F chr8:33765107 NA 0.51 8.34 0.42 1.94e-15 Body mass index; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg16606324 chr3:10149918 C3orf24 0.58 8.28 0.41 2.99e-15 Alzheimer's disease; LUSC cis rs2050392 1.000 rs2489864 chr10:30693744 C/G cg18806716 chr10:30721971 MAP3K8 -0.48 -7.74 -0.39 1.18e-13 Inflammatory bowel disease; LUSC trans rs12310956 0.532 rs1525904 chr12:33962448 T/C cg26384229 chr12:38710491 ALG10B 0.75 11.9 0.55 1.83e-27 Morning vs. evening chronotype; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg03145290 chr16:32857923 NA 0.4 6.62 0.34 1.41e-10 Calcium levels; LUSC cis rs7267979 0.549 rs6138536 chr20:25182648 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.64 11.81 0.54 4.02e-27 Liver enzyme levels (alkaline phosphatase); LUSC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg14784868 chr12:69753453 YEATS4 0.92 16.31 0.67 2.09e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg05347473 chr6:146136440 FBXO30 0.45 7.69 0.39 1.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2688608 1.000 rs2688610 chr10:75654931 A/G cg17411546 chr10:75410026 SYNPO2L 0.43 6.57 0.34 1.89e-10 Inflammatory bowel disease; LUSC cis rs9457247 0.508 rs6918286 chr6:167505829 C/T cg07741184 chr6:167504864 NA 0.39 6.9 0.35 2.56e-11 Crohn's disease; LUSC cis rs2304069 1.000 rs10072275 chr5:149401596 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.77 10.43 0.5 3.16e-22 HIV-1 control; LUSC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg27494647 chr7:150038898 RARRES2 0.49 7.42 0.38 1.01e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg13206674 chr6:150067644 NUP43 0.56 8.59 0.43 3.41e-16 Lung cancer; LUSC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg24209194 chr3:40518798 ZNF619 0.41 5.85 0.3 1.18e-8 Renal cell carcinoma; LUSC cis rs7943203 0.568 rs228593 chr11:108141134 G/A cg04873221 chr11:107992290 ACAT1 -0.4 -5.87 -0.31 1.06e-8 Red blood cell count;Mean corpuscular volume; LUSC cis rs6696846 0.740 rs11240369 chr1:205115099 G/A cg21643547 chr1:205240462 TMCC2 -0.42 -7.65 -0.39 2.14e-13 Red blood cell count; LUSC cis rs4730250 0.707 rs3729876 chr7:106786952 T/C cg02696742 chr7:106810147 HBP1 0.65 9.18 0.45 4.72e-18 Osteoarthritis; LUSC cis rs10493773 0.618 rs17394091 chr1:86075098 A/G cg17807903 chr1:86174739 ZNHIT6 -0.39 -7.65 -0.39 2.24e-13 Urate levels in overweight individuals; LUSC cis rs2625529 0.824 rs12902006 chr15:72252996 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.44 -0.38 8.62e-13 Red blood cell count; LUSC cis rs10203711 0.901 rs907104 chr2:239564564 T/G cg14580085 chr2:239553406 NA 0.41 6.99 0.36 1.47e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.51 -7.25 -0.37 2.93e-12 Height; LUSC cis rs1624802 0.841 rs78426981 chr12:130497782 A/G cg15444478 chr12:130494697 NA -0.26 -5.95 -0.31 6.81e-9 Obesity-related traits; LUSC cis rs9905704 0.881 rs12942879 chr17:56861253 G/A cg12560992 chr17:57184187 TRIM37 0.56 8.02 0.4 1.81e-14 Testicular germ cell tumor; LUSC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg20307385 chr11:47447363 PSMC3 -0.44 -5.73 -0.3 2.23e-8 Subjective well-being; LUSC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg18876405 chr7:65276391 NA -0.55 -8.51 -0.42 5.92e-16 Aortic root size; LUSC cis rs7829975 0.539 rs4841012 chr8:8551710 C/A cg15556689 chr8:8085844 FLJ10661 -0.5 -7.23 -0.37 3.37e-12 Mood instability; LUSC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg18681998 chr4:17616180 MED28 0.89 17.39 0.69 1.05e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9467773 1.000 rs6925703 chr6:26521589 G/A cg09904177 chr6:26538194 HMGN4 0.75 14.21 0.61 3.52e-36 Intelligence (multi-trait analysis); LUSC cis rs1568889 0.838 rs10835304 chr11:28296529 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 12.97 0.58 1.94e-31 Bipolar disorder; LUSC cis rs9283706 0.608 rs12522430 chr5:66339522 T/C cg11590213 chr5:66331682 MAST4 0.47 6.93 0.35 2.14e-11 Coronary artery disease; LUSC trans rs853679 0.607 rs67662114 chr6:27932301 G/A cg01620082 chr3:125678407 NA -0.8 -7.24 -0.37 3.11e-12 Depression; LUSC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.935 rs380883 chr6:145822992 A/G cg23711669 chr6:146136114 FBXO30 0.74 12.72 0.57 1.68e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs61931739 0.890 rs1197560 chr12:34121447 G/C cg06521331 chr12:34319734 NA -0.38 -6.38 -0.33 6.01e-10 Morning vs. evening chronotype; LUSC cis rs11098499 0.618 rs6858383 chr4:120296772 T/C cg09307838 chr4:120376055 NA 0.78 11.3 0.53 2.71e-25 Corneal astigmatism; LUSC cis rs912057 0.841 rs1294423 chr6:6743795 C/T cg06612196 chr6:6737390 NA 0.55 10.47 0.5 2.33e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs7582180 0.585 rs13031711 chr2:100939433 T/C cg12002119 chr2:101014098 CHST10 0.35 5.81 0.3 1.5e-8 Intelligence (multi-trait analysis); LUSC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -12.93 -0.58 2.79e-31 Hemoglobin concentration; LUSC cis rs11864453 0.826 rs2074627 chr16:72136769 C/T cg23815491 chr16:72088622 HP 0.34 5.97 0.31 6.12e-9 Fibrinogen levels; LUSC cis rs7103648 0.966 rs896817 chr11:47394305 A/G cg20307385 chr11:47447363 PSMC3 -0.92 -17.15 -0.68 1.02e-47 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs6681460 0.966 rs10889642 chr1:67143334 T/G cg02459107 chr1:67143332 SGIP1 0.48 8.88 0.44 4.15e-17 Presence of antiphospholipid antibodies; LUSC cis rs7481584 0.962 rs2237905 chr11:2976584 T/C cg08508325 chr11:3079039 CARS 0.3 5.76 0.3 1.9e-8 Calcium levels; LUSC cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.6 9.2 0.45 3.97e-18 Menarche (age at onset); LUSC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs28595532 1.000 rs11938970 chr4:119660152 A/G cg11846333 chr4:119757529 SEC24D 0.78 6.68 0.34 9.94e-11 Cannabis dependence symptom count; LUSC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 9.97 0.48 1.14e-20 Eosinophil percentage of white cells; LUSC cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg00012203 chr2:219082015 ARPC2 -0.77 -13.8 -0.6 1.38e-34 Colorectal cancer; LUSC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg01616529 chr11:638424 DRD4 -0.34 -5.8 -0.3 1.58e-8 Systemic lupus erythematosus; LUSC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.74 -0.3 2.1e-8 Alzheimer's disease (late onset); LUSC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.56 7.85 0.39 5.86e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6964587 1.000 rs4727266 chr7:91570129 C/T cg01689657 chr7:91764605 CYP51A1 -0.33 -6.06 -0.31 3.68e-9 Breast cancer; LUSC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs478304 0.593 rs4645933 chr11:65485120 C/T cg05805236 chr11:65401703 PCNXL3 -0.66 -10.47 -0.5 2.22e-22 Acne (severe); LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.39 5.96 0.31 6.31e-9 Lymphocyte counts; LUSC cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg01884057 chr2:25150051 NA 0.48 11.28 0.53 3.33e-25 Body mass index; LUSC cis rs2832077 0.943 rs2832100 chr21:30175628 A/C cg24692254 chr21:30365293 RNF160 -0.49 -6.23 -0.32 1.41e-9 Cognitive test performance; LUSC cis rs11168618 0.904 rs7135125 chr12:48926268 A/T cg24011408 chr12:48396354 COL2A1 0.39 6.34 0.33 7.56e-10 Adiponectin levels; LUSC cis rs11229555 0.645 rs11229463 chr11:58210147 A/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg23711669 chr6:146136114 FBXO30 -0.94 -18.1 -0.7 1.7e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg02018176 chr4:1364513 KIAA1530 0.46 7.67 0.39 1.9e-13 Obesity-related traits; LUSC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg18190219 chr22:46762943 CELSR1 -0.51 -6.17 -0.32 2e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs3126085 0.778 rs10788828 chr1:152191879 G/A cg26876637 chr1:152193138 HRNR 0.44 6.13 0.32 2.46e-9 Atopic dermatitis; LUSC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.78 0.35 5.33e-11 Tonsillectomy; LUSC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg02275930 chr1:2372054 NA -0.44 -7.2 -0.37 4.12e-12 Schizophrenia; LUSC cis rs7937890 0.900 rs7118682 chr11:14274550 T/G cg22961513 chr11:14280813 SPON1 0.34 5.85 0.3 1.16e-8 Mitochondrial DNA levels; LUSC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg01125463 chr6:42946178 PEX6 -0.36 -5.97 -0.31 6.19e-9 Plasma homocysteine levels (post-methionine load test); LUSC cis rs62103177 0.608 rs4799115 chr18:77736365 A/T cg20368463 chr18:77673604 PQLC1 -0.67 -6.95 -0.36 1.94e-11 Opioid sensitivity; LUSC cis rs7824557 0.564 rs13268126 chr8:11230574 G/A cg27411982 chr8:10470053 RP1L1 -0.38 -5.89 -0.31 9.56e-9 Retinal vascular caliber; LUSC trans rs4713118 0.516 rs7739216 chr6:28079946 G/T cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Parkinson's disease; LUSC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg23758822 chr17:41437982 NA 1.03 19.13 0.72 1.36e-55 Menopause (age at onset); LUSC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.02e-11 Tonsillectomy; LUSC cis rs17826219 0.568 rs9898097 chr17:29072672 T/G cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Body mass index; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg21724239 chr8:58056113 NA 0.79 9.51 0.46 3.98e-19 Developmental language disorder (linguistic errors); LUSC cis rs703842 0.585 rs10877022 chr12:58223937 A/G cg00677455 chr12:58241039 CTDSP2 0.7 11.0 0.52 3.3e-24 Multiple sclerosis; LUSC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.77 0.3 1.82e-8 Intelligence (multi-trait analysis); LUSC cis rs10186029 0.676 rs10932464 chr2:213968315 T/A cg08319019 chr2:214017104 IKZF2 0.6 8.76 0.43 9.95e-17 Systemic sclerosis; LUSC cis rs2797160 1.000 rs1739377 chr6:126012236 T/C cg05901451 chr6:126070800 HEY2 0.57 8.58 0.42 3.72e-16 Endometrial cancer; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg08219700 chr8:58056026 NA 0.64 8.24 0.41 3.88e-15 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs1972460 0.506 rs62012050 chr15:82532274 T/G cg04831495 chr15:85060580 GOLGA6L5 -0.55 -8.54 -0.42 4.91e-16 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg05896524 chr21:47604654 C21orf56 0.53 8.14 0.41 7.98e-15 Testicular germ cell tumor; LUSC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg15445000 chr17:37608096 MED1 0.4 6.89 0.35 2.83e-11 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.88e-19 Developmental language disorder (linguistic errors); LUSC trans rs1941687 0.797 rs8086041 chr18:31402756 G/A cg27147174 chr7:100797783 AP1S1 -0.43 -6.33 -0.33 7.78e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12484325 chr11:3688985 CHRNA10 -0.85 -6.83 -0.35 4.12e-11 Cognitive performance; LUSC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg06363034 chr20:62225388 GMEB2 -0.46 -7.75 -0.39 1.11e-13 Glioblastoma; LUSC cis rs4948102 0.642 rs766333 chr7:56126704 T/A cg17215666 chr7:56131930 SUMF2 0.46 6.34 0.33 7.59e-10 Plasma homocysteine levels (post-methionine load test); LUSC cis rs12210905 0.688 rs72839471 chr6:27316959 C/T cg08851530 chr6:28072375 NA 0.9 5.78 0.3 1.75e-8 Hip circumference adjusted for BMI; LUSC cis rs360798 0.532 rs360797 chr2:62942840 C/T cg17519650 chr2:63277830 OTX1 -0.54 -7.64 -0.39 2.35e-13 Coronary artery disease; LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08109568 chr15:31115862 NA 0.49 7.13 0.36 6.39e-12 Huntington's disease progression; LUSC trans rs67539049 1.000 rs77865852 chr8:11303336 A/G cg26241650 chr22:40417538 FAM83F 0.43 5.99 0.31 5.54e-9 Itch intensity from mosquito bite; LUSC cis rs9287719 0.934 rs6727884 chr2:10757557 C/T cg00105475 chr2:10696890 NA -0.38 -6.27 -0.32 1.14e-9 Prostate cancer; LUSC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg03806693 chr22:41940476 POLR3H 0.88 12.29 0.56 7.03e-29 Vitiligo; LUSC cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg03146154 chr1:46216737 IPP -0.51 -7.46 -0.38 7.41e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11690935 1.000 rs6433311 chr2:172549248 A/G cg13550731 chr2:172543902 DYNC1I2 0.89 14.93 0.63 5.8e-39 Schizophrenia; LUSC cis rs950776 0.518 rs12910100 chr15:78822667 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs9457247 1.000 rs404222 chr6:167402150 G/A cg23791538 chr6:167370224 RNASET2 -0.41 -6.49 -0.33 3.02e-10 Crohn's disease; LUSC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg27068330 chr11:65405492 SIPA1 -0.45 -5.95 -0.31 6.62e-9 Breast cancer; LUSC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.12 16.67 0.67 7.63e-46 Age-related macular degeneration (geographic atrophy); LUSC cis rs778371 1.000 rs11535 chr2:233743532 G/C cg08000102 chr2:233561755 GIGYF2 -0.74 -11.26 -0.52 3.85e-25 Schizophrenia; LUSC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg25282410 chr6:160211355 TCP1;MRPL18 1.06 15.99 0.66 3.89e-43 Age-related macular degeneration (geographic atrophy); LUSC cis rs344364 0.511 rs2917515 chr16:1945271 G/C cg26897989 chr16:1907736 C16orf73 -0.46 -6.81 -0.35 4.67e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.27 -0.37 2.57e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg18350739 chr11:68623251 NA -0.36 -6.35 -0.33 7.2e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1451375 0.698 rs56233242 chr7:50634053 C/A cg18232548 chr7:50535776 DDC 0.52 7.97 0.4 2.49e-14 Malaria; LUSC trans rs6952808 0.723 rs4721287 chr7:2028663 A/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.41 0.33 4.9e-10 Bipolar disorder and schizophrenia; LUSC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg13866156 chr1:1669148 SLC35E2 0.55 9.11 0.45 7.93e-18 Body mass index; LUSC cis rs7180079 1.000 rs7165405 chr15:64662900 C/T cg02848875 chr15:64387786 SNX1 -0.4 -5.67 -0.3 3.07e-8 Monocyte count; LUSC cis rs1577917 0.917 rs13213603 chr6:86534758 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs1942 1.000 rs1942 chr15:41774423 A/G cg18705301 chr15:41695430 NDUFAF1 -0.41 -6.45 -0.33 3.99e-10 Eosinophil percentage of granulocytes; LUSC cis rs1865721 0.804 rs719179 chr18:73146396 A/G cg26385618 chr18:73139727 C18orf62 -0.53 -9.74 -0.47 6.68e-20 Intelligence; LUSC cis rs477692 0.837 rs543454 chr10:131420536 T/C cg05714579 chr10:131428358 MGMT 0.52 7.9 0.4 4e-14 Response to temozolomide; LUSC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.05 16.05 0.66 2.22e-43 Age-related macular degeneration (geographic atrophy); LUSC cis rs2625529 0.730 rs6494990 chr15:72401074 T/A cg16672083 chr15:72433130 SENP8 0.5 8.23 0.41 4.26e-15 Red blood cell count; LUSC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.68 0.3 2.98e-8 Tonsillectomy; LUSC cis rs1595825 0.891 rs57340905 chr2:198565823 C/T cg00982548 chr2:198649783 BOLL -0.55 -7.05 -0.36 1.03e-11 Ulcerative colitis; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg21548813 chr6:291882 DUSP22 -0.71 -11.7 -0.54 9.53e-27 Menopause (age at onset); LUSC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg05855489 chr10:104503620 C10orf26 0.66 10.06 0.48 5.56e-21 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs12618769 0.543 rs4851132 chr2:99042782 T/C cg10123293 chr2:99228465 UNC50 0.45 7.64 0.39 2.31e-13 Bipolar disorder; LUSC cis rs2797160 0.967 rs2797162 chr6:126011381 G/T cg05901451 chr6:126070800 HEY2 0.57 8.56 0.42 4.25e-16 Endometrial cancer; LUSC cis rs180358 0.568 rs1268353 chr11:116639692 C/T cg08985259 chr11:116699649 APOC3 0.27 6.02 0.31 4.67e-9 Multiple sclerosis (severity); LUSC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.79 0.35 5.21e-11 Tonsillectomy; LUSC cis rs1728785 1.000 rs11647432 chr16:68565426 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs3824867 0.804 rs12419342 chr11:47468545 C/T cg20307385 chr11:47447363 PSMC3 0.65 9.46 0.46 5.81e-19 Mean corpuscular hemoglobin; LUSC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg12292205 chr6:26970375 C6orf41 -0.52 -8.64 -0.43 2.31e-16 Schizophrenia; LUSC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg04287289 chr16:89883240 FANCA 0.77 6.23 0.32 1.42e-9 Skin colour saturation; LUSC cis rs7208859 0.623 rs9898084 chr17:29082334 C/G cg13385521 chr17:29058706 SUZ12P 0.68 6.84 0.35 3.86e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9987353 0.544 rs2929469 chr8:9062656 T/G cg15556689 chr8:8085844 FLJ10661 0.42 5.9 0.31 9.05e-9 Recombination measurement; LUSC trans rs12210905 0.925 rs7753123 chr6:26991540 G/C cg11837749 chr1:55047332 ACOT11 0.55 6.0 0.31 5.25e-9 Hip circumference adjusted for BMI; LUSC trans rs61931739 0.635 rs7138254 chr12:33914422 G/T cg13010199 chr12:38710504 ALG10B 0.41 6.12 0.32 2.65e-9 Morning vs. evening chronotype; LUSC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg16228356 chr17:43848958 NA 0.25 5.86 0.31 1.13e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg17294928 chr15:75287854 SCAMP5 -0.76 -10.12 -0.48 3.67e-21 Blood trace element (Zn levels); LUSC trans rs853679 0.517 rs9468298 chr6:28122345 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.19e-9 Depression; LUSC cis rs10089 1.000 rs4836363 chr5:127462737 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.99 0.55 8.74e-28 Ileal carcinoids; LUSC cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg12698349 chr2:225449008 CUL3 0.69 8.57 0.42 3.83e-16 IgE levels in asthmatics (D.p. specific); LUSC cis rs7147624 0.938 rs7151148 chr14:65936665 G/C cg03016385 chr14:66212404 NA -0.81 -9.5 -0.46 4.2e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg12463550 chr7:65579703 CRCP 0.47 7.06 0.36 9.86e-12 Aortic root size; LUSC cis rs11645898 0.630 rs72791135 chr16:72259718 G/C cg14768367 chr16:72042858 DHODH -0.57 -5.89 -0.31 9.64e-9 Blood protein levels; LUSC cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg24642439 chr20:33292090 TP53INP2 -0.52 -7.93 -0.4 3.32e-14 Glomerular filtration rate (creatinine); LUSC trans rs4662863 0.529 rs17049003 chr2:129766337 A/G cg05506011 chr3:118864587 C3orf30;IGSF11 0.36 6.08 0.32 3.2e-9 Gut microbiome composition (winter); LUSC cis rs9649213 0.511 rs6950994 chr7:97887872 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.68 -0.3 2.91e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg27266060 chr8:22091797 NA 0.39 7.12 0.36 6.62e-12 Hypertriglyceridemia; LUSC cis rs4499344 0.633 rs259260 chr19:33153261 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.42 0.53 1.02e-25 Mean platelet volume; LUSC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg18350739 chr11:68623251 NA -0.36 -6.29 -0.33 9.83e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9311676 0.656 rs11130632 chr3:58369324 C/T cg26110898 chr3:58419937 PDHB 0.42 6.88 0.35 2.97e-11 Systemic lupus erythematosus; LUSC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg24733560 chr20:60626293 TAF4 0.42 7.58 0.38 3.34e-13 Body mass index; LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg25036284 chr2:26402008 FAM59B -0.76 -11.1 -0.52 1.35e-24 Gut microbiome composition (summer); LUSC cis rs911119 1.000 rs6114208 chr20:23621734 C/G cg16589663 chr20:23618590 CST3 0.59 6.95 0.36 1.96e-11 Chronic kidney disease; LUSC cis rs8014204 0.868 rs2230237 chr14:75359670 G/A cg08847533 chr14:75593920 NEK9 -0.39 -5.68 -0.3 2.98e-8 Caffeine consumption; LUSC cis rs4474465 0.833 rs11606128 chr11:78156960 T/C cg27205649 chr11:78285834 NARS2 -0.51 -5.97 -0.31 6.15e-9 Alzheimer's disease (survival time); LUSC cis rs7560272 0.538 rs17434655 chr2:73923089 C/T cg20560298 chr2:73613845 ALMS1 -0.4 -6.12 -0.32 2.66e-9 Schizophrenia; LUSC cis rs12474201 0.832 rs4953419 chr2:46989869 T/G cg06386533 chr2:46925753 SOCS5 0.66 9.62 0.47 1.66e-19 Height; LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg12564285 chr5:131593104 PDLIM4 0.56 10.77 0.51 2e-23 Acylcarnitine levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04667467 chr16:90089176 GAS8 -0.47 -6.3 -0.33 9.45e-10 Bipolar disorder and schizophrenia; LUSC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg14829155 chr15:31115871 NA 0.56 6.95 0.36 1.93e-11 Huntington's disease progression; LUSC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg02503808 chr4:7069936 GRPEL1 1.0 14.09 0.61 1.01e-35 Monocyte percentage of white cells; LUSC trans rs7613875 0.580 rs6808044 chr3:50136165 A/G cg21659725 chr3:3221576 CRBN -0.55 -8.6 -0.43 3.23e-16 Body mass index; LUSC cis rs965469 1.000 rs6037547 chr20:3299228 C/A cg25506879 chr20:3388711 C20orf194 -0.52 -5.66 -0.3 3.18e-8 IFN-related cytopenia; LUSC trans rs61931739 0.500 rs6416261 chr12:34540377 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs2370759 1.000 rs79578760 chr10:32611264 C/A cg01819863 chr10:32635814 EPC1 1.06 12.87 0.58 4.58e-31 Sexual dysfunction (female); LUSC cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg23711669 chr6:146136114 FBXO30 0.9 17.15 0.68 1.03e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg17971929 chr21:40555470 PSMG1 0.78 13.72 0.6 2.7e-34 Cognitive function; LUSC cis rs6951245 0.572 rs73264028 chr7:1045455 G/A cg24642844 chr7:1081250 C7orf50 -0.69 -6.56 -0.34 2.02e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.74 0.47 6.84e-20 Height; LUSC cis rs6546886 0.912 rs6741544 chr2:74294221 T/C cg14702570 chr2:74259524 NA -0.31 -5.85 -0.31 1.15e-8 Dialysis-related mortality; LUSC cis rs9788682 0.747 rs3743078 chr15:78894759 C/G cg06917634 chr15:78832804 PSMA4 0.48 6.18 0.32 1.83e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs478304 0.651 rs10896037 chr11:65503424 A/G cg27068330 chr11:65405492 SIPA1 -0.76 -10.87 -0.51 9.41e-24 Acne (severe); LUSC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.79e-10 Schizophrenia; LUSC cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs10751667 0.600 rs7394783 chr11:1005108 C/T ch.11.42038R chr11:967971 AP2A2 -0.44 -6.7 -0.34 8.96e-11 Alzheimer's disease (late onset); LUSC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.84 -11.33 -0.53 2.16e-25 Schizophrenia; LUSC cis rs208520 0.909 rs9354410 chr6:67018584 C/T cg07460842 chr6:66804631 NA 0.87 8.76 0.43 1.01e-16 Exhaled nitric oxide output; LUSC cis rs12410462 0.581 rs77837509 chr1:227559873 C/T cg23173402 chr1:227635558 NA 0.56 6.26 0.32 1.2e-9 Major depressive disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02710346 chr3:148805157 HLTF -0.75 -6.07 -0.32 3.38e-9 Cognitive performance; LUSC cis rs11031096 0.568 rs10767891 chr11:4234524 A/G cg18678763 chr11:4115507 RRM1 -0.4 -5.65 -0.3 3.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11098499 0.754 rs1511025 chr4:120240238 T/C cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC cis rs2014572 0.933 rs8107516 chr19:57758445 A/G cg24459738 chr19:57751996 ZNF805 -0.52 -7.68 -0.39 1.83e-13 Hyperactive-impulsive symptoms; LUSC cis rs7843479 0.601 rs6557712 chr8:21826421 C/T cg17168535 chr8:21777572 XPO7 0.86 15.72 0.65 4.39e-42 Mean corpuscular volume; LUSC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg08677398 chr8:58056175 NA 0.52 6.29 0.33 9.86e-10 Developmental language disorder (linguistic errors); LUSC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg11845111 chr2:191398756 TMEM194B 0.54 9.11 0.45 7.98e-18 Pulse pressure; LUSC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg21770322 chr7:97807741 LMTK2 0.5 8.58 0.43 3.54e-16 Breast cancer; LUSC cis rs11677416 1.000 rs1878320 chr2:113544467 T/C cg27083787 chr2:113543245 IL1A 0.45 7.13 0.36 6.29e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC trans rs9401746 0.646 rs693793 chr6:124789269 A/G cg16857858 chr7:27213984 HOXA10 0.55 6.32 0.33 8.57e-10 Bone mineral density (Ward's triangle area); LUSC cis rs7903847 0.642 rs10786339 chr10:99153076 A/G cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.24e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg02711726 chr17:80685570 FN3KRP -0.41 -6.22 -0.32 1.52e-9 Glycated hemoglobin levels; LUSC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg22834771 chr12:69754056 YEATS4 -0.5 -7.44 -0.38 8.41e-13 Blood protein levels; LUSC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg04013166 chr16:89971882 TCF25 -0.68 -8.24 -0.41 3.96e-15 Skin colour saturation; LUSC trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg03929089 chr4:120376271 NA 0.73 8.86 0.44 4.73e-17 Coronary artery disease; LUSC cis rs9326248 0.581 rs6589590 chr11:116936081 A/C cg26566898 chr11:117069891 TAGLN 0.35 6.69 0.34 9.68e-11 Blood protein levels; LUSC cis rs909341 0.909 rs6122158 chr20:62363096 G/A cg09650180 chr20:62225654 GMEB2 -0.45 -5.85 -0.31 1.14e-8 Atopic dermatitis; LUSC cis rs2652834 1.000 rs36116701 chr15:63397494 T/C cg05507819 chr15:63340323 TPM1 0.68 8.27 0.41 3.21e-15 HDL cholesterol; LUSC cis rs16966142 1.000 rs3890534 chr16:89835289 A/G cg26513180 chr16:89883248 FANCA -0.76 -6.9 -0.35 2.58e-11 Caffeine consumption; LUSC cis rs208520 0.754 rs7753158 chr6:66875633 A/C cg07460842 chr6:66804631 NA -1.04 -15.6 -0.65 1.29e-41 Exhaled nitric oxide output; LUSC cis rs1953600 0.870 rs2789690 chr10:81938204 G/T cg00277334 chr10:82204260 NA 0.45 7.12 0.36 6.71e-12 Sarcoidosis; LUSC cis rs5769707 0.740 rs79946167 chr22:50017556 G/A cg07959070 chr22:50026188 C22orf34 -0.31 -6.3 -0.33 9.24e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg08219700 chr8:58056026 NA 0.46 6.02 0.31 4.64e-9 Developmental language disorder (linguistic errors); LUSC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg16479474 chr6:28041457 NA -0.33 -5.85 -0.31 1.14e-8 Depression; LUSC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg18196295 chr10:418757 DIP2C 0.5 8.32 0.41 2.28e-15 Psychosis in Alzheimer's disease; LUSC cis rs4820539 1.000 rs3788347 chr22:23467804 G/A cg21100191 chr22:23484243 RTDR1 0.89 15.1 0.64 1.26e-39 Bone mineral density; LUSC cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg17173187 chr15:85201210 NMB 0.37 5.99 0.31 5.29e-9 Schizophrenia; LUSC cis rs10887741 0.690 rs4934358 chr10:89439744 C/A cg24243914 chr10:89418206 PAPSS2 0.34 6.9 0.35 2.64e-11 Exercise (leisure time); LUSC cis rs7524258 0.868 rs8179413 chr1:7267729 T/G cg07173049 chr1:7289937 CAMTA1 0.35 7.25 0.37 2.85e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs478304 0.651 rs4930313 chr11:65500428 C/T cg10518572 chr11:65560635 OVOL1 -0.25 -5.75 -0.3 1.97e-8 Acne (severe); LUSC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.48 7.02 0.36 1.27e-11 Schizophrenia; LUSC cis rs7267979 0.565 rs13040726 chr20:25559881 T/G cg03522245 chr20:25566470 NINL -0.39 -6.06 -0.31 3.64e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs950169 0.580 rs11635597 chr15:85165699 C/T cg17507749 chr15:85114479 UBE2QP1 0.56 7.14 0.36 5.77e-12 Schizophrenia; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg02136620 chr5:178986620 RUFY1 0.51 8.34 0.42 1.91e-15 Lung cancer; LUSC cis rs7789940 0.951 rs7779014 chr7:75975586 C/T cg10167463 chr7:75959203 YWHAG -0.66 -10.07 -0.48 5.33e-21 Multiple sclerosis; LUSC cis rs3771570 0.792 rs4675970 chr2:242200406 G/A cg21155796 chr2:242212141 HDLBP 0.6 7.04 0.36 1.1e-11 Prostate cancer; LUSC cis rs1376877 0.519 rs10197623 chr2:204243759 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.48 6.15 0.32 2.16e-9 Subclinical atherosclerosis traits (other); LUSC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -9.97 -0.48 1.14e-20 Personality dimensions; LUSC cis rs4919694 1.000 rs17881215 chr10:104629236 G/C cg23093090 chr10:104574429 C10orf26 -0.49 -6.07 -0.32 3.4e-9 Arsenic metabolism; LUSC cis rs7267979 0.816 rs8115257 chr20:25207931 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.69 13.14 0.58 4.41e-32 Liver enzyme levels (alkaline phosphatase); LUSC cis rs908922 0.573 rs7544564 chr1:152527007 A/C cg20991723 chr1:152506922 NA 0.48 9.12 0.45 6.99e-18 Hair morphology; LUSC trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg27661571 chr11:113659931 NA -0.68 -7.8 -0.39 8.18e-14 Hip circumference adjusted for BMI; LUSC cis rs4285028 0.948 rs34543553 chr3:121675637 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.57 -0.46 2.41e-19 Multiple sclerosis; LUSC cis rs34779708 0.931 rs34815241 chr10:35296676 T/C cg03585969 chr10:35415529 CREM 0.6 8.73 0.43 1.27e-16 Inflammatory bowel disease;Crohn's disease; LUSC trans rs683250 0.730 rs2374424 chr11:83187113 A/G cg26617787 chr11:123396133 GRAMD1B 0.3 6.06 0.31 3.7e-9 Subcortical brain region volumes; LUSC cis rs7107174 0.901 rs4944199 chr11:78122779 A/G cg02023728 chr11:77925099 USP35 0.4 5.89 0.31 9.23e-9 Testicular germ cell tumor; LUSC cis rs7224314 0.895 rs11654663 chr17:65389305 A/C cg01507342 chr17:65387096 PITPNC1 -0.44 -7.71 -0.39 1.5e-13 Diisocyanate-induced asthma; LUSC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg26818010 chr10:134567672 INPP5A -0.84 -10.95 -0.51 4.73e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg12463550 chr7:65579703 CRCP 0.56 8.38 0.42 1.53e-15 Aortic root size; LUSC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg19346786 chr7:2764209 NA -0.46 -7.71 -0.39 1.41e-13 Height; LUSC cis rs4704187 0.687 rs13360638 chr5:74433258 G/A cg03227963 chr5:74354835 NA 0.3 6.51 0.34 2.8e-10 Response to amphetamines; LUSC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg20203395 chr5:56204925 C5orf35 -0.48 -7.29 -0.37 2.32e-12 Breast cancer;Breast cancer (early onset); LUSC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg05025164 chr4:1340916 KIAA1530 0.5 8.05 0.4 1.42e-14 Obesity-related traits; LUSC cis rs12980942 0.872 rs66724427 chr19:41776257 A/G cg25627403 chr19:41769009 HNRNPUL1 0.59 6.49 0.33 3.13e-10 Coronary artery disease; LUSC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg21171335 chr12:122356390 WDR66 0.64 9.81 0.47 3.96e-20 Mean platelet volume; LUSC cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14240646 chr10:27532245 ACBD5 -0.66 -7.8 -0.39 8.22e-14 Breast cancer; LUSC cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.17e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs28374715 0.681 rs7168307 chr15:41620534 A/G cg18705301 chr15:41695430 NDUFAF1 -0.93 -18.56 -0.71 2.52e-53 Ulcerative colitis; LUSC cis rs3020736 0.500 rs4147640 chr22:42485292 T/C cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg05347473 chr6:146136440 FBXO30 -0.41 -7.02 -0.36 1.27e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg26647111 chr11:31128758 NA -0.43 -6.22 -0.32 1.48e-9 Red blood cell count; LUSC cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg23625390 chr15:77176239 SCAPER 0.54 8.33 0.41 2.18e-15 Blood metabolite levels; LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg08470875 chr2:26401718 FAM59B 0.74 10.13 0.48 3.38e-21 Gut microbiome composition (summer); LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.58 0.67 1.84e-45 Platelet count; LUSC cis rs7917772 0.545 rs3934960 chr10:104355275 A/G cg22532475 chr10:104410764 TRIM8 0.26 6.14 0.32 2.32e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg22166914 chr1:53195759 ZYG11B -0.7 -12.19 -0.55 1.63e-28 Monocyte count; LUSC cis rs2130392 0.962 rs35613786 chr4:185625657 A/G cg04058563 chr4:185651563 MLF1IP -0.41 -6.67 -0.34 1.06e-10 Kawasaki disease; LUSC cis rs2963155 0.518 rs853178 chr5:142634799 C/T cg17617527 chr5:142782415 NR3C1 0.7 8.24 0.41 3.96e-15 Breast cancer; LUSC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg16240275 chr20:61666158 NCRNA00029 0.42 9.29 0.45 1.97e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6494488 0.500 rs72744764 chr15:65076887 G/A cg08069370 chr15:64387884 SNX1 -0.65 -5.91 -0.31 8.23e-9 Coronary artery disease; LUSC cis rs7572733 0.534 rs771009 chr2:198691082 A/G cg00792783 chr2:198669748 PLCL1 0.43 5.68 0.3 3.01e-8 Dermatomyositis; LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -5.89 -0.31 9.42e-9 Platelet count; LUSC cis rs11626933 1.000 rs4559843 chr14:90747488 T/C cg14092571 chr14:90743983 NA -0.89 -18.83 -0.72 2.03e-54 Gut microbiota (bacterial taxa); LUSC cis rs5769765 0.955 rs8135816 chr22:50291976 G/C cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.04 0.36 1.07e-11 Schizophrenia; LUSC cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.93 -0.44 2.85e-17 Monocyte percentage of white cells; LUSC cis rs6076065 1.000 rs2424533 chr20:23375907 C/T cg11657817 chr20:23433608 CST11 0.44 8.66 0.43 2.12e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg20608306 chr11:116969690 SIK3 0.38 6.33 0.33 8.09e-10 Blood protein levels; LUSC cis rs250677 0.798 rs11168080 chr5:148409821 C/T cg18129178 chr5:148520854 ABLIM3 -0.64 -9.41 -0.46 8.54e-19 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00556132 chr3:11684351 VGLL4 -0.42 -6.36 -0.33 6.65e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10089 0.953 rs7713860 chr5:127428789 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.33 0.56 4.73e-29 Ileal carcinoids; LUSC cis rs9865818 0.791 rs4686955 chr3:188106379 A/G cg23651889 chr3:188115336 LPP 0.39 5.91 0.31 8.23e-9 Allergic sensitization; LUSC cis rs9902453 0.619 rs2244585 chr17:28072176 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.68 -0.5 4.31e-23 Coffee consumption (cups per day); LUSC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg12826209 chr6:26865740 GUSBL1 0.75 9.0 0.44 1.72e-17 Intelligence (multi-trait analysis); LUSC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg07343612 chr16:622815 PIGQ -0.75 -13.15 -0.58 4.26e-32 Height; LUSC cis rs8060686 0.545 rs12597573 chr16:68167521 A/C cg05110241 chr16:68378359 PRMT7 0.66 7.04 0.36 1.13e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2729354 0.953 rs2649650 chr11:57327567 C/T cg24343310 chr11:57249947 NA 0.34 6.26 0.32 1.15e-9 Blood protein levels; LUSC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.39 0.33 5.58e-10 Intelligence (multi-trait analysis); LUSC cis rs3008870 0.755 rs2815363 chr1:67497221 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.74 -12.2 -0.56 1.48e-28 Lymphocyte percentage of white cells; LUSC cis rs983392 0.709 rs11230194 chr11:59980315 C/G cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.1e-9 Alzheimer's disease (late onset); LUSC cis rs11098499 0.909 rs73842633 chr4:120375464 G/A cg24375607 chr4:120327624 NA 0.77 11.13 0.52 1.13e-24 Corneal astigmatism; LUSC cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 29.27 0.85 3.41e-94 Chronic sinus infection; LUSC cis rs7267979 0.528 rs34485039 chr20:25583763 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -12.37 -0.56 3.44e-29 Liver enzyme levels (alkaline phosphatase); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22438603 chr5:127418940 SLC12A2;FLJ33630 -0.53 -7.07 -0.36 8.83e-12 Bipolar disorder and schizophrenia; LUSC cis rs11792861 0.926 rs7046725 chr9:111882729 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.94 0.44 2.8e-17 Menarche (age at onset); LUSC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg12463550 chr7:65579703 CRCP 0.59 5.73 0.3 2.27e-8 Diabetic kidney disease; LUSC cis rs7106204 0.858 rs2403889 chr11:24210226 T/C ch.11.24196551F chr11:24239977 NA 1.13 12.76 0.57 1.21e-30 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2274273 0.592 rs2878174 chr14:55470624 T/C cg04306507 chr14:55594613 LGALS3 0.42 8.91 0.44 3.47e-17 Protein biomarker; LUSC cis rs9469578 0.901 rs57303110 chr6:33706159 G/A cg18708504 chr6:33715942 IP6K3 0.73 9.08 0.44 9.9e-18 Phosphorus levels; LUSC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg03264133 chr6:25882463 NA -0.53 -8.82 -0.43 6.36e-17 Intelligence (multi-trait analysis); LUSC cis rs2361710 0.704 rs12937349 chr17:78120320 G/C cg06718696 chr17:78121285 EIF4A3 0.44 6.33 0.33 7.81e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs2075671 0.903 rs4729602 chr7:100260591 T/C cg20848291 chr7:100343083 ZAN -0.59 -7.99 -0.4 2.26e-14 Other erythrocyte phenotypes; LUSC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg00310523 chr12:86230176 RASSF9 0.49 9.42 0.46 7.56e-19 Major depressive disorder; LUSC cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.11 0.41 9.98e-15 Axial length; LUSC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg05855489 chr10:104503620 C10orf26 0.59 8.99 0.44 1.94e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs926938 0.527 rs2335954 chr1:115534151 C/T cg01522456 chr1:115632236 TSPAN2 0.43 6.75 0.35 6.72e-11 Autism; LUSC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC trans rs6952808 1.000 rs6977733 chr7:1886725 A/T cg24247370 chr13:99142703 STK24 0.33 6.17 0.32 1.92e-9 Bipolar disorder and schizophrenia; LUSC cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Alcohol dependence; LUSC cis rs59104589 0.617 rs16843642 chr2:242351379 T/G cg14842376 chr2:242211374 HDLBP 0.56 6.63 0.34 1.32e-10 Fibrinogen levels; LUSC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.08 -0.48 4.71e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11543725 chr11:10329292 NA -0.47 -6.36 -0.33 6.58e-10 Bipolar disorder and schizophrenia; LUSC cis rs9457247 0.534 rs2345568 chr6:167381804 A/G cg23791538 chr6:167370224 RNASET2 0.5 8.28 0.41 3.04e-15 Crohn's disease; LUSC cis rs9297145 0.724 rs62473013 chr7:98762418 G/T cg05967295 chr7:98741636 SMURF1 0.95 13.67 0.6 4.25e-34 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs12760731 0.623 rs2300300 chr1:178419387 G/C cg00404053 chr1:178313656 RASAL2 0.48 5.67 0.3 3.16e-8 Obesity-related traits; LUSC cis rs6469656 0.892 rs10086419 chr8:117744771 C/T cg24004040 chr8:117650383 NA -0.43 -6.23 -0.32 1.4e-9 Colorectal cancer; LUSC cis rs7666738 0.546 rs10010088 chr4:98655945 C/T cg05340658 chr4:99064831 C4orf37 0.59 8.83 0.43 6.11e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg01689657 chr7:91764605 CYP51A1 0.32 5.82 0.3 1.42e-8 Breast cancer; LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg25036284 chr2:26402008 FAM59B 0.77 10.92 0.51 5.98e-24 Gut microbiome composition (summer); LUSC cis rs6121246 0.609 rs1009453 chr20:30404840 C/G cg18721089 chr20:30220636 NA -0.31 -5.67 -0.3 3.02e-8 Mean corpuscular hemoglobin; LUSC cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg15423357 chr2:25149977 NA 0.44 8.76 0.43 1.03e-16 Body mass index; LUSC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg00745463 chr17:30367425 LRRC37B -0.83 -9.75 -0.47 6.44e-20 Hip circumference adjusted for BMI; LUSC cis rs7712401 0.569 rs10080185 chr5:122351856 A/G cg19077854 chr5:122220652 SNX24 -0.27 -6.25 -0.32 1.23e-9 Mean platelet volume; LUSC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg04414720 chr1:150670196 GOLPH3L -0.49 -7.76 -0.39 1.07e-13 Tonsillectomy; LUSC cis rs748404 0.631 rs8042688 chr15:43638525 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.46 6.48 0.33 3.22e-10 Lung cancer; LUSC trans rs11098499 0.863 rs10009626 chr4:120470005 T/C cg25214090 chr10:38739885 LOC399744 0.54 7.98 0.4 2.39e-14 Corneal astigmatism; LUSC cis rs4702 0.611 rs7177338 chr15:91428636 G/A cg05469396 chr15:91419421 FURIN 0.46 8.18 0.41 6.19e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs453301 0.571 rs2929454 chr8:9083854 A/C cg21775007 chr8:11205619 TDH -0.44 -6.2 -0.32 1.69e-9 Joint mobility (Beighton score); LUSC cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg03146154 chr1:46216737 IPP -0.57 -8.28 -0.41 2.93e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3126085 0.935 rs6587647 chr1:152192631 C/T cg26876637 chr1:152193138 HRNR 0.44 6.13 0.32 2.46e-9 Atopic dermatitis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07133894 chr22:32808171 C22orf28 -0.49 -6.39 -0.33 5.5e-10 Hepatitis; LUSC cis rs4474465 0.850 rs11237546 chr11:78266924 T/C cg27205649 chr11:78285834 NARS2 0.52 6.11 0.32 2.71e-9 Alzheimer's disease (survival time); LUSC cis rs11098499 0.691 rs12502524 chr4:120271414 G/A cg24375607 chr4:120327624 NA 0.66 10.52 0.5 1.48e-22 Corneal astigmatism; LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg11062466 chr8:58055876 NA -0.5 -6.92 -0.35 2.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg21361702 chr7:150065534 REPIN1 0.56 8.24 0.41 4.1e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg23630131 chr7:65973040 NA -0.2 -5.72 -0.3 2.34e-8 Aortic root size; LUSC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg21770322 chr7:97807741 LMTK2 0.4 7.03 0.36 1.18e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs300703 0.515 rs424292 chr2:191931 C/T cg21211680 chr2:198530 NA -0.52 -6.32 -0.33 8.23e-10 Blood protein levels; LUSC cis rs3771570 0.901 rs3771587 chr2:242409701 A/G cg21155796 chr2:242212141 HDLBP 0.61 6.86 0.35 3.35e-11 Prostate cancer; LUSC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg04414720 chr1:150670196 GOLPH3L 0.49 7.88 0.4 4.66e-14 Tonsillectomy; LUSC cis rs7572644 0.709 rs7607546 chr2:28118662 G/A cg27432699 chr2:27873401 GPN1 -0.52 -6.44 -0.33 4.27e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs6500602 0.826 rs7205189 chr16:4460114 A/G cg08645402 chr16:4508243 NA 0.49 7.34 0.37 1.66e-12 Schizophrenia; LUSC cis rs13256369 0.950 rs1522839 chr8:8580453 C/T cg06671706 chr8:8559999 CLDN23 0.49 6.36 0.33 6.69e-10 Obesity-related traits; LUSC cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg19628046 chr18:33552617 C18orf21 0.52 6.36 0.33 6.8e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg22601191 chr20:60968625 CABLES2 0.41 5.95 0.31 6.76e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs4729127 0.908 rs55746023 chr7:94006138 G/A cg20086523 chr13:52378287 DHRS12 0.54 6.31 0.33 8.9e-10 Intelligence; LUSC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg08219700 chr8:58056026 NA -0.45 -5.95 -0.31 6.94e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.11e-9 Developmental language disorder (linguistic errors); LUSC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg18240062 chr17:79603768 NPLOC4 -0.8 -15.53 -0.65 2.54e-41 Eye color traits; LUSC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.55e-10 Life satisfaction; LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg14092988 chr3:52407081 DNAH1 0.32 6.28 0.33 1.05e-9 Bipolar disorder; LUSC trans rs2587949 0.615 rs2600113 chr3:4225734 T/G cg15139668 chr4:4577005 NA -0.42 -6.25 -0.32 1.28e-9 Periodontitis (DPAL); LUSC cis rs10504229 0.680 rs16921675 chr8:58052082 A/G cg22535103 chr8:58192502 C8orf71 -0.56 -6.74 -0.35 7.17e-11 Developmental language disorder (linguistic errors); LUSC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg23791538 chr6:167370224 RNASET2 0.42 6.77 0.35 5.78e-11 Crohn's disease; LUSC trans rs7939886 0.920 rs17150095 chr11:55902900 A/G cg03929089 chr4:120376271 NA 0.77 6.09 0.32 3.03e-9 Myopia (pathological); LUSC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs11039100 0.850 rs35990969 chr11:5834242 G/A cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9388451 0.839 rs980014 chr6:126068001 T/G cg10911889 chr6:126070802 HEY2 0.42 6.44 0.33 4.14e-10 Brugada syndrome; LUSC cis rs478304 0.651 rs10896037 chr11:65503424 A/G cg10518572 chr11:65560635 OVOL1 -0.25 -5.78 -0.3 1.76e-8 Acne (severe); LUSC cis rs3808502 0.647 rs7821302 chr8:11236572 T/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.9 -0.31 8.72e-9 Neuroticism; LUSC cis rs16854884 0.657 rs6766685 chr3:143736916 C/T cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg21535247 chr6:8435926 SLC35B3 0.6 9.36 0.46 1.23e-18 Motion sickness; LUSC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg09455208 chr3:40491958 NA 0.58 10.55 0.5 1.17e-22 Renal cell carcinoma; LUSC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg12292205 chr6:26970375 C6orf41 -0.58 -7.16 -0.36 5.14e-12 Intelligence (multi-trait analysis); LUSC cis rs10843647 1.000 rs1586280 chr12:30325540 G/T cg12718339 chr12:29936407 TMTC1 -0.35 -5.89 -0.31 9.61e-9 Glucose homeostasis traits; LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.21 0.52 5.93e-25 Prudent dietary pattern; LUSC cis rs2445762 0.584 rs17602588 chr15:51655475 A/T cg07517944 chr15:51633816 GLDN 0.39 6.5 0.34 2.84e-10 Hormone measurements; LUSC cis rs7772486 0.558 rs2142980 chr6:146080679 G/A cg23711669 chr6:146136114 FBXO30 -0.7 -9.96 -0.48 1.22e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg22800045 chr5:56110881 MAP3K1 0.79 10.02 0.48 7.68e-21 Initial pursuit acceleration; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg01238044 chr22:24384105 GSTT1 -0.53 -7.79 -0.39 8.77e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.91e-16 Menopause (age at onset); LUSC cis rs11997175 0.603 rs11778978 chr8:33804743 G/T ch.8.33884649F chr8:33765107 NA 0.42 6.36 0.33 6.55e-10 Body mass index; LUSC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg17385448 chr1:15911702 AGMAT 0.35 5.83 0.3 1.33e-8 Systolic blood pressure; LUSC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.04 0.31 4.11e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1499972 0.941 rs62264763 chr3:117637305 G/A cg07612923 chr3:117604196 NA 0.62 5.64 0.3 3.54e-8 Schizophrenia; LUSC trans rs2229238 0.911 rs111600849 chr1:154487489 G/A cg25273160 chr11:56955011 LRRC55 0.32 6.23 0.32 1.44e-9 Coronary heart disease; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg02018176 chr4:1364513 KIAA1530 0.53 9.24 0.45 2.99e-18 Obesity-related traits; LUSC cis rs2579519 0.547 rs11683523 chr2:96544855 T/C cg23100626 chr2:96804247 ASTL 0.29 6.83 0.35 4.03e-11 Diastolic blood pressure; LUSC cis rs826838 0.616 rs7966266 chr12:38626138 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.45 -0.42 8.99e-16 Heart rate; LUSC cis rs72781680 0.898 rs10490751 chr2:24001356 A/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs9503598 0.714 rs11242859 chr6:3454032 G/A cg00476032 chr6:3446245 SLC22A23 0.38 7.59 0.38 3.22e-13 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC cis rs12137294 0.794 rs1172160 chr1:205207015 G/A cg21643547 chr1:205240462 TMCC2 -0.36 -6.46 -0.33 3.74e-10 Red cell distribution width; LUSC cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg22601191 chr20:60968625 CABLES2 0.55 9.49 0.46 4.45e-19 Colorectal cancer; LUSC cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs7760949 0.889 rs9475795 chr6:13931270 A/C cg27413430 chr6:13925136 RNF182 0.6 9.2 0.45 3.94e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs2652822 1.000 rs1126309 chr15:63429062 A/G cg02713581 chr15:63449717 RPS27L 0.4 6.46 0.33 3.69e-10 Metabolic traits; LUSC cis rs9462027 0.585 rs188190 chr6:34551086 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.03 -0.31 4.43e-9 Systemic lupus erythematosus; LUSC cis rs1018836 0.632 rs7017630 chr8:91482604 A/G cg16814680 chr8:91681699 NA -0.66 -9.9 -0.48 1.9e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg06028605 chr16:24865363 SLC5A11 0.5 8.62 0.43 2.69e-16 Intelligence (multi-trait analysis); LUSC cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg00857998 chr1:205179979 DSTYK 0.61 9.24 0.45 2.97e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.74 0.35 6.84e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6912958 0.712 rs2307379 chr6:88366771 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -7.06 -0.36 9.86e-12 Monocyte percentage of white cells; LUSC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg14820908 chr5:178986412 RUFY1 0.56 9.79 0.47 4.73e-20 Lung cancer; LUSC cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg13319975 chr6:146136371 FBXO30 0.49 7.37 0.37 1.31e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs886126 1.000 rs876027 chr12:111678458 A/T cg10833066 chr12:111807467 FAM109A 0.4 6.56 0.34 2.05e-10 Coronary heart disease; LUSC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg17971929 chr21:40555470 PSMG1 0.51 7.96 0.4 2.65e-14 Cognitive function; LUSC cis rs7824557 0.628 rs3174048 chr8:11184937 G/A cg21775007 chr8:11205619 TDH 0.79 13.15 0.58 4.09e-32 Retinal vascular caliber; LUSC cis rs4780401 0.632 rs7192366 chr16:11835209 C/G cg01061890 chr16:11836724 TXNDC11 -0.56 -8.47 -0.42 8.12e-16 Rheumatoid arthritis; LUSC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg26897989 chr16:1907736 C16orf73 0.48 7.21 0.37 3.84e-12 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7937682 1.000 rs11213973 chr11:111538903 A/T cg22437258 chr11:111473054 SIK2 0.48 6.45 0.33 4.01e-10 Primary sclerosing cholangitis; LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg00166722 chr3:10149974 C3orf24 0.53 7.36 0.37 1.41e-12 Alzheimer's disease; LUSC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.44e-8 Extrinsic epigenetic age acceleration; LUSC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg07936489 chr17:37558343 FBXL20 -0.71 -9.84 -0.47 3.21e-20 Glomerular filtration rate (creatinine); LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 13.4 0.59 4.48e-33 Alzheimer's disease; LUSC cis rs6496667 0.533 rs886491 chr15:90993215 G/A cg22089800 chr15:90895588 ZNF774 0.53 7.56 0.38 3.96e-13 Rheumatoid arthritis; LUSC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg07395648 chr5:131743802 NA -0.41 -6.45 -0.33 3.85e-10 Breast cancer;Mosquito bite size; LUSC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.02 14.89 0.63 8.02e-39 Age-related macular degeneration (geographic atrophy); LUSC cis rs3892630 0.824 rs35654350 chr19:33223766 T/C cg22980127 chr19:33182716 NUDT19 0.92 12.61 0.57 4.49e-30 Red blood cell traits; LUSC trans rs7613875 0.580 rs2624819 chr3:50010571 G/T cg21659725 chr3:3221576 CRBN 0.52 8.17 0.41 6.5e-15 Body mass index; LUSC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.53 9.38 0.46 1.02e-18 Menopause (age at onset); LUSC cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg02423579 chr7:2872169 GNA12 -0.41 -6.41 -0.33 4.97e-10 Height; LUSC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.52 -8.41 -0.42 1.18e-15 IgG glycosylation; LUSC cis rs13401104 0.686 rs72620812 chr2:237118765 C/T cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs6940638 1.000 rs12215241 chr6:27023081 G/A cg05738196 chr6:26577821 NA -0.5 -5.65 -0.3 3.46e-8 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg08280861 chr8:58055591 NA 0.53 5.8 0.3 1.53e-8 Developmental language disorder (linguistic errors); LUSC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg20203395 chr5:56204925 C5orf35 -0.72 -9.84 -0.47 3.21e-20 Initial pursuit acceleration; LUSC cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg12310025 chr6:25882481 NA -0.5 -9.07 -0.44 1.03e-17 Blood metabolite levels; LUSC cis rs4654899 1.000 rs4654899 chr1:21410231 G/T cg01072550 chr1:21505969 NA -0.54 -8.53 -0.42 5.19e-16 Superior frontal gyrus grey matter volume; LUSC cis rs12579753 0.789 rs35448307 chr12:82165817 A/G cg07988820 chr12:82153109 PPFIA2 -0.42 -6.25 -0.32 1.22e-9 Resting heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02916409 chr16:2510063 C16orf59 0.41 6.13 0.32 2.53e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs709400 1.000 rs57218990 chr14:104128007 T/A cg24130564 chr14:104152367 KLC1 -0.54 -7.82 -0.39 6.77e-14 Body mass index; LUSC cis rs950776 0.518 rs4887062 chr15:78837801 G/A cg22563815 chr15:78856949 CHRNA5 -0.26 -6.23 -0.32 1.41e-9 Sudden cardiac arrest; LUSC cis rs478607 0.915 rs61884449 chr11:64485193 C/T cg19131476 chr11:64387923 NRXN2 0.34 5.89 0.31 9.28e-9 Urate levels; LUSC cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg23583168 chr7:148888333 NA -0.9 -16.73 -0.68 4.51e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11958404 0.932 rs72816580 chr5:157432221 A/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs9916302 0.706 rs8078599 chr17:37518660 C/T cg07936489 chr17:37558343 FBXL20 0.81 9.95 0.48 1.31e-20 Glomerular filtration rate (creatinine); LUSC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg18350739 chr11:68623251 NA -0.37 -6.34 -0.33 7.66e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs477692 0.905 rs4751106 chr10:131424653 G/T cg11019008 chr10:131425282 MGMT -0.41 -6.28 -0.32 1.08e-9 Response to temozolomide; LUSC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg09165964 chr15:75287851 SCAMP5 -1.01 -15.09 -0.64 1.33e-39 Blood trace element (Zn levels); LUSC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg02038168 chr22:39784481 NA -0.47 -7.53 -0.38 4.64e-13 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg22903657 chr4:1355424 KIAA1530 -0.38 -6.43 -0.33 4.46e-10 Longevity; LUSC cis rs9790314 0.875 rs55688744 chr3:160944222 G/A cg03342759 chr3:160939853 NMD3 -0.57 -9.73 -0.47 7.28e-20 Morning vs. evening chronotype; LUSC trans rs6951245 0.554 rs2070118 chr7:1132505 G/A cg13565492 chr6:43139072 SRF -0.74 -10.65 -0.5 5.16e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9325144 0.647 rs7957185 chr12:38909710 G/A cg26384229 chr12:38710491 ALG10B -0.59 -9.01 -0.44 1.6e-17 Morning vs. evening chronotype; LUSC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg00701064 chr4:6280414 WFS1 0.58 14.08 0.61 1.13e-35 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg11141652 chr22:24348549 GSTTP1 0.38 5.79 0.3 1.63e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg23590916 chr17:43697445 MGC57346 -0.49 -6.64 -0.34 1.25e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg09436375 chr6:42928200 GNMT -0.29 -6.82 -0.35 4.33e-11 Plasma homocysteine levels (post-methionine load test); LUSC cis rs2677744 0.626 rs11207 chr15:91497239 C/T cg22570213 chr15:91497863 RCCD1 0.39 5.7 0.3 2.57e-8 Attention deficit hyperactivity disorder; LUSC trans rs11098499 0.865 rs4001305 chr4:120359236 G/T cg25214090 chr10:38739885 LOC399744 0.54 8.03 0.4 1.7e-14 Corneal astigmatism; LUSC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.44 -0.46 6.41e-19 Chronic sinus infection; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg27094323 chr7:1216898 NA -0.43 -7.47 -0.38 7.24e-13 Longevity;Endometriosis; LUSC cis rs7589342 0.929 rs7562054 chr2:106433513 G/C cg16077055 chr2:106428750 NCK2 0.38 7.26 0.37 2.75e-12 Addiction; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23016766 chr1:33116697 RBBP4;ZBTB8OS -0.47 -6.98 -0.36 1.56e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4400599 0.572 rs7516809 chr1:154205501 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.84 -0.3 1.26e-8 Platelet distribution width; LUSC cis rs7586879 0.964 rs11688665 chr2:25121168 G/T cg01884057 chr2:25150051 NA 0.42 8.87 0.44 4.34e-17 Body mass index; LUSC cis rs5769707 0.632 rs5770601 chr22:50021903 A/G cg07959070 chr22:50026188 C22orf34 -0.32 -5.71 -0.3 2.51e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11214589 0.774 rs7107223 chr11:113255574 A/T cg14159747 chr11:113255604 NA 0.32 8.22 0.41 4.5e-15 Neuroticism; LUSC cis rs6500395 1.000 rs9938308 chr16:48607229 A/G cg04672837 chr16:48644449 N4BP1 0.46 6.89 0.35 2.76e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.48 0.33 3.36e-10 Menarche (age at onset); LUSC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg18230493 chr5:56204884 C5orf35 -0.87 -12.96 -0.58 2.16e-31 Initial pursuit acceleration; LUSC cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg01657329 chr11:68192670 LRP5 -0.42 -6.36 -0.33 6.68e-10 Total body bone mineral density; LUSC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg18654377 chr3:49208889 KLHDC8B -0.43 -5.66 -0.3 3.28e-8 Menarche (age at onset); LUSC cis rs929354 1.000 rs8101 chr7:157061474 A/G cg05182265 chr7:156933206 UBE3C 0.48 7.12 0.36 6.64e-12 Body mass index; LUSC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg13699009 chr12:122356056 WDR66 0.51 8.15 0.41 7.36e-15 Mean platelet volume; LUSC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg20503657 chr10:835505 NA 0.99 14.13 0.61 7.27e-36 Eosinophil percentage of granulocytes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14176475 chr9:135282081 TTF1 0.44 6.33 0.33 8.05e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8017423 0.967 rs7154683 chr14:90700692 A/G cg04374321 chr14:90722782 PSMC1 0.73 11.56 0.53 3.11e-26 Mortality in heart failure; LUSC cis rs2439831 1.000 rs689596 chr15:43761717 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs6942756 0.806 rs10248810 chr7:128993806 G/A cg02491457 chr7:128862824 NA -0.5 -7.33 -0.37 1.73e-12 White matter hyperintensity burden; LUSC trans rs2039659 0.719 rs1753741 chr13:86250565 A/G cg22803222 chr6:76636725 IMPG1 0.38 6.06 0.31 3.77e-9 Blood osmolality (transformed sodium); LUSC trans rs62238980 0.614 rs79173736 chr22:32379966 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg21545522 chr1:205238299 TMCC2 0.5 9.4 0.46 9.21e-19 Mean corpuscular volume;Mean platelet volume; LUSC trans rs57046232 0.552 rs6133307 chr20:6333298 C/T cg21095983 chr6:86352623 SYNCRIP 0.47 7.02 0.36 1.26e-11 Colorectal cancer; LUSC cis rs10927875 0.562 rs10803401 chr1:16147377 G/A cg21385522 chr1:16154831 NA -1.02 -20.42 -0.75 1.04e-60 Dilated cardiomyopathy; LUSC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg02569458 chr12:86230093 RASSF9 0.57 9.54 0.46 3.09e-19 Major depressive disorder; LUSC cis rs734999 0.566 rs10752747 chr1:2524915 G/T cg18932078 chr1:2524107 MMEL1 0.32 7.12 0.36 6.57e-12 Ulcerative colitis; LUSC cis rs713587 0.563 rs1529897 chr2:25086827 T/G cg01884057 chr2:25150051 NA 0.44 10.07 0.48 5.3e-21 Body mass index in non-asthmatics; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16327326 chr16:1662895 IFT140 0.38 6.81 0.35 4.48e-11 Triglycerides; LUSC cis rs2860975 0.501 rs602941 chr10:96961184 G/A cg09036531 chr10:96991505 NA -0.62 -10.18 -0.49 2.18e-21 Immune response to smallpox vaccine (IL-6); LUSC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs62400317 0.762 rs12214794 chr6:44931465 G/A cg18551225 chr6:44695536 NA -0.45 -7.23 -0.37 3.38e-12 Total body bone mineral density; LUSC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg07256732 chr16:621771 PIGQ -0.36 -6.42 -0.33 4.56e-10 Height; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg18538332 chr22:24372958 LOC391322 -0.49 -8.74 -0.43 1.12e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10979 1.000 rs9376762 chr6:143887248 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.01 -0.55 7.28e-28 Hypospadias; LUSC cis rs12760731 0.720 rs12037817 chr1:178261750 A/G cg00404053 chr1:178313656 RASAL2 0.58 6.29 0.33 1e-9 Obesity-related traits; LUSC cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg13010199 chr12:38710504 ALG10B 0.7 10.81 0.51 1.48e-23 Bladder cancer; LUSC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg13798912 chr7:905769 UNC84A 0.59 5.97 0.31 6.05e-9 Cerebrospinal P-tau181p levels; LUSC cis rs11055008 0.620 rs2111941 chr12:12829404 A/T cg04607235 chr12:12878440 APOLD1 0.51 7.56 0.38 3.87e-13 Pulse pressure; LUSC cis rs7681440 0.605 rs1372509 chr4:90817311 A/G cg20003494 chr4:90757398 SNCA -0.35 -5.87 -0.31 1.07e-8 Dementia with Lewy bodies; LUSC cis rs7681440 0.647 rs11941110 chr4:90819569 T/C cg15133208 chr4:90757351 SNCA -0.36 -5.98 -0.31 5.72e-9 Dementia with Lewy bodies; LUSC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg24920358 chr1:40204285 PPIE 0.6 10.8 0.51 1.64e-23 Blood protein levels; LUSC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg12963246 chr6:28129442 ZNF389 0.42 6.47 0.33 3.5e-10 Parkinson's disease; LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg13010199 chr12:38710504 ALG10B 0.7 10.75 0.51 2.4e-23 Bladder cancer; LUSC cis rs28655083 1.000 rs28655083 chr16:77061214 C/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.42 -6.33 -0.33 7.84e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg04369109 chr6:150039330 LATS1 -0.6 -8.83 -0.43 6.2e-17 Lung cancer; LUSC cis rs12477438 0.520 rs13031919 chr2:99848932 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.15 23.78 0.79 7.4e-74 Chronic sinus infection; LUSC cis rs34779708 0.931 rs2384275 chr10:35297142 A/G cg04310649 chr10:35416472 CREM -0.4 -6.27 -0.32 1.13e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg19318889 chr4:1322082 MAEA 0.48 7.69 0.39 1.68e-13 Obesity-related traits; LUSC cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg26314531 chr2:26401878 FAM59B 0.66 8.91 0.44 3.32e-17 Gut microbiome composition (summer); LUSC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg10909506 chr17:38081995 ORMDL3 0.34 6.03 0.31 4.45e-9 Self-reported allergy; LUSC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg19052272 chr2:3704530 ALLC -0.49 -8.19 -0.41 5.6e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg08888203 chr3:10149979 C3orf24 0.58 7.61 0.38 2.91e-13 Alzheimer's disease; LUSC cis rs1953600 0.687 rs3851054 chr10:81933306 A/G cg00277334 chr10:82204260 NA 0.36 5.72 0.3 2.4e-8 Sarcoidosis; LUSC cis rs6460942 0.591 rs62448727 chr7:12332362 G/C cg06484146 chr7:12443880 VWDE -0.57 -5.98 -0.31 5.79e-9 Coronary artery disease; LUSC cis rs981844 1.000 rs2606328 chr4:154653864 C/T cg10279832 chr4:154682576 RNF175 -0.38 -5.91 -0.31 8.4e-9 Response to statins (LDL cholesterol change); LUSC cis rs1957429 0.901 rs1467571 chr14:65347682 C/T cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs73206853 0.841 rs73191839 chr12:110967652 G/T cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1371867 0.875 rs1962901 chr8:101326428 A/G cg06002616 chr8:101225028 SPAG1 -0.41 -6.83 -0.35 4.11e-11 Atrioventricular conduction; LUSC cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg26384229 chr12:38710491 ALG10B 0.92 15.67 0.65 7e-42 Bladder cancer; LUSC cis rs7098414 0.511 rs7907575 chr10:82152675 T/G cg00277334 chr10:82204260 NA -0.59 -9.81 -0.47 4.05e-20 Post bronchodilator FEV1; LUSC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.7 -11.17 -0.52 8.08e-25 Monocyte percentage of white cells; LUSC cis rs9948 0.529 rs62156208 chr2:97383686 A/G cg01990225 chr2:97406019 LMAN2L -1.09 -7.42 -0.38 9.98e-13 Erectile dysfunction and prostate cancer treatment; LUSC cis rs13082711 0.911 rs6773733 chr3:27502131 C/A cg02860705 chr3:27208620 NA 0.5 8.35 0.42 1.86e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6121246 0.909 rs8126355 chr20:30332660 C/T cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.81 0.54 3.94e-27 Prudent dietary pattern; LUSC cis rs10771431 0.597 rs10771413 chr12:9354413 C/T cg08997352 chr12:9597637 DDX12 -0.71 -11.07 -0.52 1.83e-24 Breast size; LUSC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 5.83 0.3 1.33e-8 Menopause (age at onset); LUSC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg15649852 chr7:65879115 NA -0.4 -5.66 -0.3 3.23e-8 Aortic root size; LUSC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg23711669 chr6:146136114 FBXO30 0.9 16.79 0.68 2.66e-46 Lobe attachment (rater-scored or self-reported); LUSC trans rs9393777 0.920 rs55834529 chr6:27072542 A/G cg06606381 chr12:133084897 FBRSL1 -0.97 -8.2 -0.41 5.16e-15 Intelligence (multi-trait analysis); LUSC cis rs1256061 0.646 rs1256059 chr14:64710417 A/G cg21174375 chr14:64681225 SYNE2 0.32 5.81 0.3 1.45e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -7.96 -0.4 2.65e-14 Schizophrenia; LUSC cis rs9311676 0.656 rs11130634 chr3:58379123 A/C cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs6977660 0.943 rs10225293 chr7:19840636 C/T cg07541023 chr7:19748670 TWISTNB -0.52 -6.01 -0.31 4.8e-9 Thyroid stimulating hormone; LUSC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg06481639 chr22:41940642 POLR3H 0.51 5.8 0.3 1.51e-8 Vitiligo; LUSC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.8 10.48 0.5 2.06e-22 Schizophrenia; LUSC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg25427524 chr10:38739819 LOC399744 -0.66 -12.01 -0.55 7.21e-28 Extrinsic epigenetic age acceleration; LUSC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.23e-10 Extrinsic epigenetic age acceleration; LUSC cis rs4363385 0.747 rs2339493 chr1:152975277 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC trans rs2624839 0.629 rs2526397 chr3:50187790 A/C cg21659725 chr3:3221576 CRBN -0.46 -7.03 -0.36 1.16e-11 Intelligence (multi-trait analysis); LUSC cis rs68170813 0.523 rs4730241 chr7:107057361 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.06 -0.44 1.15e-17 Coronary artery disease; LUSC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg03433033 chr1:76189801 ACADM 0.75 11.6 0.54 2.29e-26 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6960043 0.743 rs1002061 chr7:15039499 A/T cg19272540 chr7:15055459 NA -0.35 -8.39 -0.42 1.35e-15 Type 2 diabetes; LUSC cis rs1595825 0.891 rs892513 chr2:198905874 A/G cg10547527 chr2:198650123 BOLL 0.49 5.79 0.3 1.63e-8 Ulcerative colitis; LUSC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg18230493 chr5:56204884 C5orf35 -0.95 -14.05 -0.61 1.46e-35 Type 2 diabetes; LUSC cis rs7647973 0.626 rs12715437 chr3:49751856 T/C cg03060546 chr3:49711283 APEH 0.63 7.35 0.37 1.52e-12 Menarche (age at onset); LUSC cis rs7107174 1.000 rs1017908 chr11:77948095 A/G cg02023728 chr11:77925099 USP35 0.46 6.33 0.33 7.78e-10 Testicular germ cell tumor; LUSC cis rs6942756 1.000 rs7806089 chr7:128972215 C/G cg02491457 chr7:128862824 NA -0.48 -6.47 -0.33 3.56e-10 White matter hyperintensity burden; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg16405210 chr4:1374714 KIAA1530 0.79 13.73 0.6 2.63e-34 Longevity; LUSC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg13114125 chr14:105738426 BRF1 -0.9 -15.55 -0.65 2.13e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg23283495 chr1:209979779 IRF6 0.56 7.63 0.39 2.55e-13 Cleft lip with or without cleft palate; LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.83 0.35 3.98e-11 Platelet count; LUSC cis rs7091068 0.721 rs618951 chr10:95404967 A/G cg20715218 chr10:95462985 C10orf4 -0.62 -7.25 -0.37 2.98e-12 Urinary tract infection frequency; LUSC cis rs7615316 1.000 rs6784089 chr3:142356496 T/C cg16271453 chr3:142027066 XRN1 -0.34 -5.74 -0.3 2.09e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2625529 0.526 rs7183810 chr15:72560458 A/T cg16672083 chr15:72433130 SENP8 0.47 7.71 0.39 1.45e-13 Red blood cell count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18417464 chr7:139025179 C7orf55 -0.4 -5.99 -0.31 5.56e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg06634786 chr22:41940651 POLR3H 0.49 5.78 0.3 1.74e-8 Vitiligo; LUSC cis rs546131 0.890 rs485845 chr11:34830389 G/T cg06937548 chr11:34938143 PDHX;APIP -0.41 -5.66 -0.3 3.25e-8 Lung disease severity in cystic fibrosis; LUSC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.71 0.54 9.16e-27 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12579753 1.000 rs2401004 chr12:82214822 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.08 -0.32 3.31e-9 Resting heart rate; LUSC cis rs8099014 1.000 rs4637007 chr18:56126282 G/A cg12907477 chr18:56117327 MIR122 0.44 6.9 0.35 2.6e-11 Platelet count; LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg04166393 chr7:2884313 GNA12 0.43 5.66 0.3 3.31e-8 Height; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.86 -0.58 4.88e-31 Alzheimer's disease; LUSC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg18230493 chr5:56204884 C5orf35 -0.92 -13.91 -0.61 5.09e-35 Initial pursuit acceleration; LUSC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg08859206 chr1:53392774 SCP2 0.46 7.75 0.39 1.1e-13 Monocyte count; LUSC cis rs9646944 0.531 rs17027029 chr2:102990648 G/C cg20060108 chr2:102954350 IL1RL1 0.48 6.35 0.33 6.92e-10 Blood protein levels; LUSC cis rs3947 0.906 rs709822 chr8:11702313 C/G cg00262122 chr8:11665843 FDFT1 -0.6 -7.98 -0.4 2.4e-14 Blood protein levels; LUSC cis rs2948294 0.524 rs13270062 chr8:8112650 C/A cg06636001 chr8:8085503 FLJ10661 0.74 10.4 0.49 3.89e-22 Red cell distribution width; LUSC cis rs7954584 0.710 rs10840641 chr12:122465831 G/T cg21171335 chr12:122356390 WDR66 0.42 6.04 0.31 4.22e-9 Mean corpuscular volume; LUSC cis rs1461503 0.868 rs7126785 chr11:122839564 C/A cg27398637 chr11:122830231 C11orf63 -0.4 -6.51 -0.34 2.81e-10 Menarche (age at onset); LUSC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg17340268 chr14:105411764 AHNAK2 -0.38 -6.07 -0.32 3.45e-9 Rheumatoid arthritis; LUSC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg07636037 chr3:49044803 WDR6 0.44 6.39 0.33 5.46e-10 Resting heart rate; LUSC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.49 -0.33 3.09e-10 High light scatter reticulocyte count; LUSC cis rs6840360 0.615 rs2406973 chr4:152608339 G/T cg22705602 chr4:152727874 NA 0.35 7.6 0.38 3.1e-13 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg09177884 chr7:1199841 ZFAND2A -0.45 -6.49 -0.33 3.07e-10 Longevity;Endometriosis; LUSC cis rs9902453 0.845 rs7501472 chr17:28010628 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.53 0.46 3.29e-19 Coffee consumption (cups per day); LUSC cis rs4474465 1.000 rs10899511 chr11:78170923 T/A cg27205649 chr11:78285834 NARS2 -0.48 -5.74 -0.3 2.14e-8 Alzheimer's disease (survival time); LUSC cis rs6754311 0.593 rs7355359 chr2:136462441 C/T cg07169764 chr2:136633963 MCM6 -0.55 -7.3 -0.37 2.16e-12 Mosquito bite size; LUSC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg23649088 chr2:200775458 C2orf69 -0.58 -7.13 -0.36 6.36e-12 Schizophrenia; LUSC trans rs9944715 0.954 rs8086610 chr18:43844658 A/C cg01718231 chr17:29326311 RNF135 -0.48 -6.56 -0.34 2.06e-10 Red cell distribution width;Mean corpuscular volume; LUSC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg14784868 chr12:69753453 YEATS4 0.61 8.54 0.42 4.9e-16 Response to diuretic therapy; LUSC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg18681998 chr4:17616180 MED28 0.85 15.99 0.66 3.99e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg08045932 chr20:61659980 NA 0.6 10.57 0.5 1.04e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs6460942 1.000 rs77010200 chr7:12290724 G/A cg06484146 chr7:12443880 VWDE -0.58 -6.06 -0.31 3.64e-9 Coronary artery disease; LUSC cis rs2688608 0.934 rs2675679 chr10:75658581 C/T cg17411546 chr10:75410026 SYNPO2L -0.43 -6.37 -0.33 6.36e-10 Inflammatory bowel disease; LUSC cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg03264133 chr6:25882463 NA 0.62 10.38 0.49 4.71e-22 Blood metabolite levels; LUSC cis rs6456156 0.565 rs12525345 chr6:167478875 T/C cg07741184 chr6:167504864 NA 0.4 7.1 0.36 7.74e-12 Primary biliary cholangitis; LUSC cis rs7666738 0.546 rs34159897 chr4:98787367 T/C cg03676636 chr4:99064102 C4orf37 0.3 5.99 0.31 5.55e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs737008 0.960 rs11640295 chr16:11390728 C/G cg00044050 chr16:11439710 C16orf75 0.57 8.62 0.43 2.71e-16 Obesity-related traits; LUSC cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Drug-induced liver injury (flucloxacillin); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13802269 chr4:120133706 USP53 -0.45 -6.68 -0.34 9.99e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.03 0.31 4.3e-9 Schizophrenia; LUSC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.72 7.21 0.37 3.65e-12 Initial pursuit acceleration; LUSC trans rs208520 0.955 rs208538 chr6:66964492 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.26 -0.56 8.59e-29 Exhaled nitric oxide output; LUSC cis rs394563 1.000 rs394563 chr6:149797014 T/G cg07828024 chr6:149772892 ZC3H12D -0.32 -7.04 -0.36 1.1e-11 Dupuytren's disease; LUSC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg23262073 chr20:60523788 NA -0.46 -6.81 -0.35 4.43e-11 Body mass index; LUSC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg04871131 chr7:94954202 PON1 -0.38 -6.06 -0.31 3.74e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.35e-11 Total body bone mineral density; LUSC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs4555082 0.874 rs78923231 chr14:105754033 C/T cg13114125 chr14:105738426 BRF1 -0.94 -15.18 -0.64 5.83e-40 Mean platelet volume;Platelet distribution width; LUSC cis rs7100689 0.622 rs1417221 chr10:82100428 G/A cg01528321 chr10:82214614 TSPAN14 0.83 12.43 0.56 2.11e-29 Post bronchodilator FEV1; LUSC cis rs6964587 1.000 rs6944591 chr7:91642714 T/C cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.08e-8 Breast cancer; LUSC cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg08975724 chr8:8085496 FLJ10661 0.55 8.03 0.4 1.7e-14 Neuroticism; LUSC cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg04450456 chr4:17643702 FAM184B 0.35 5.77 0.3 1.81e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7903847 0.642 rs11189191 chr10:99148796 T/C cg20016023 chr10:99160130 RRP12 -0.34 -7.9 -0.4 4.1e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg14004847 chr7:1930337 MAD1L1 0.47 6.98 0.36 1.59e-11 Bipolar disorder and schizophrenia; LUSC cis rs4474465 0.850 rs10899549 chr11:78255389 T/C cg27205649 chr11:78285834 NARS2 0.51 6.17 0.32 2.03e-9 Alzheimer's disease (survival time); LUSC cis rs983392 0.836 rs7946992 chr11:59944810 T/C cg20284999 chr11:59952153 MS4A6A -0.38 -6.25 -0.32 1.25e-9 Alzheimer's disease (late onset); LUSC cis rs9612 1.000 rs2277745 chr19:44259077 C/T cg08581076 chr19:44259116 C19orf61 0.55 6.88 0.35 3.03e-11 Exhaled nitric oxide output; LUSC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg05025164 chr4:1340916 KIAA1530 0.64 9.77 0.47 5.24e-20 Longevity; LUSC cis rs7923609 0.967 rs2393977 chr10:65247609 A/C cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.1e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs2439831 0.850 rs28413881 chr15:44174099 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.72 6.78 0.35 5.61e-11 Lung cancer in ever smokers; LUSC cis rs67460515 0.563 rs11922959 chr3:160828871 A/G cg03342759 chr3:160939853 NMD3 -0.44 -6.11 -0.32 2.7e-9 Parkinson's disease; LUSC cis rs1775715 0.811 rs1775741 chr10:32267284 C/T cg26784012 chr10:32216390 ARHGAP12 -0.43 -6.97 -0.36 1.7e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11051970 0.918 rs11051969 chr12:32537123 T/C cg02745156 chr12:32552066 NA 0.44 7.05 0.36 1.05e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1065852 0.526 rs12166549 chr22:42410419 T/C cg22189786 chr22:42395067 WBP2NL 0.43 5.77 0.3 1.78e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC trans rs7824557 0.593 rs11774673 chr8:11191537 T/C cg15556689 chr8:8085844 FLJ10661 0.46 6.9 0.35 2.6e-11 Retinal vascular caliber; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25460985 chr2:74055950 STAMBP 0.45 6.12 0.32 2.58e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs10266483 0.705 rs599522 chr7:63758482 A/G cg24201672 chr7:64023550 ZNF680 -0.45 -5.82 -0.3 1.38e-8 Response to statin therapy; LUSC trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg03929089 chr4:120376271 NA 0.82 11.44 0.53 8.55e-26 Coronary artery disease; LUSC cis rs1662342 1.000 rs7811 chr18:3256112 A/G cg00760847 chr18:3262519 MYL12B -0.59 -5.81 -0.3 1.44e-8 QRS duration; LUSC cis rs4604732 0.527 rs77361748 chr1:247626475 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs4654899 0.785 rs7531381 chr1:21403348 A/G cg01072550 chr1:21505969 NA -0.51 -7.75 -0.39 1.11e-13 Superior frontal gyrus grey matter volume; LUSC cis rs12824058 0.831 rs11608407 chr12:130805869 G/A cg23887609 chr12:130822674 PIWIL1 0.48 7.11 0.36 7.08e-12 Menopause (age at onset); LUSC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.99 -0.36 1.51e-11 Lung cancer; LUSC cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg23711669 chr6:146136114 FBXO30 -0.88 -17.33 -0.69 1.92e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs9463078 0.546 rs10948191 chr6:44947281 G/T cg25276700 chr6:44698697 NA 0.28 5.69 0.3 2.85e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg16339924 chr4:17578868 LAP3 0.53 8.03 0.4 1.72e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9796 0.870 rs7181816 chr15:41358720 T/A cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.98 -0.36 1.55e-11 Menopause (age at onset); LUSC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11890956 chr21:40555474 PSMG1 1.03 20.27 0.74 4.12e-60 Cognitive function; LUSC cis rs540254 0.504 rs11265492 chr1:160799274 C/T cg20255094 chr1:160771763 LY9 0.54 6.56 0.34 2.04e-10 Blood protein levels; LUSC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9467773 0.935 rs4573 chr6:26546808 A/G cg09904177 chr6:26538194 HMGN4 0.72 12.91 0.58 3.29e-31 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs2412459 0.611 rs4924402 chr15:40245754 C/T cg25407064 chr15:40226267 EIF2AK4 -0.51 -5.67 -0.3 3.09e-8 Response to haloperidol in psychosis; LUSC cis rs12368653 0.641 rs7311632 chr12:58086340 A/C cg12615879 chr12:58013172 SLC26A10 0.36 8.43 0.42 1.07e-15 Multiple sclerosis; LUSC cis rs6424115 0.830 rs2229584 chr1:24200969 T/C cg15997130 chr1:24165203 NA 0.52 8.58 0.43 3.6e-16 Immature fraction of reticulocytes; LUSC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg20406979 chr6:167373233 NA -0.26 -6.22 -0.32 1.5e-9 Crohn's disease; LUSC cis rs12519773 0.526 rs4242240 chr5:92517203 A/G cg18783429 chr5:92414398 NA 0.33 7.03 0.36 1.17e-11 Migraine; LUSC cis rs9549367 0.826 rs1885688 chr13:113894236 G/T cg18105134 chr13:113819100 PROZ -0.64 -9.35 -0.46 1.26e-18 Platelet distribution width; LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg08200582 chr11:442649 ANO9 -0.53 -6.13 -0.32 2.49e-9 Body mass index; LUSC cis rs425277 0.917 rs78609670 chr1:2045886 G/T cg03732007 chr1:2071316 PRKCZ 0.46 7.33 0.37 1.77e-12 Height; LUSC cis rs7605827 0.930 rs6431699 chr2:15540281 A/G cg19274914 chr2:15703543 NA 0.46 8.98 0.44 2.07e-17 Educational attainment (years of education); LUSC cis rs6977660 1.000 rs6955510 chr7:19821333 G/C cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs9868809 0.505 rs11719291 chr3:48735706 A/G cg00383909 chr3:49044727 WDR6 1.03 9.81 0.47 4.11e-20 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs2048656 0.535 rs2014514 chr8:9647196 A/T cg15556689 chr8:8085844 FLJ10661 0.5 7.44 0.38 8.61e-13 Schizophrenia; LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.22 0.52 5.34e-25 Prudent dietary pattern; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg10150615 chr22:24372951 LOC391322 -0.42 -6.82 -0.35 4.24e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg07636037 chr3:49044803 WDR6 1.04 18.16 0.7 9.65e-52 Parkinson's disease; LUSC cis rs12422267 0.536 rs7976530 chr12:132609140 C/T cg26561844 chr12:132562101 EP400 -0.53 -5.65 -0.3 3.46e-8 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs8072100 0.539 rs36043200 chr17:45629406 G/A cg25173405 chr17:45401733 C17orf57 0.39 6.16 0.32 2.03e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7100689 0.577 rs873395 chr10:82037215 C/T cg01528321 chr10:82214614 TSPAN14 -0.97 -14.46 -0.62 3.97e-37 Post bronchodilator FEV1; LUSC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg04518342 chr5:131593106 PDLIM4 -0.32 -5.81 -0.3 1.47e-8 Breast cancer;Mosquito bite size; LUSC cis rs4629180 0.586 rs57563359 chr2:102125309 A/G cg01388757 chr2:102091195 RFX8 -0.36 -6.14 -0.32 2.38e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs16854884 0.632 rs1910691 chr3:143656905 G/A cg06585982 chr3:143692056 C3orf58 0.52 8.16 0.41 6.68e-15 Economic and political preferences (feminism/equality); LUSC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11890956 chr21:40555474 PSMG1 -0.74 -11.41 -0.53 1.14e-25 Menarche (age at onset); LUSC cis rs4555082 0.957 rs2816609 chr14:105720803 A/C cg13114125 chr14:105738426 BRF1 -0.91 -14.94 -0.63 5.2e-39 Mean platelet volume;Platelet distribution width; LUSC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.51 7.94 0.4 3.2e-14 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs17685 0.535 rs41299460 chr7:75600951 G/A cg19862616 chr7:65841803 NCRNA00174 0.46 6.2 0.32 1.7e-9 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.57 8.65 0.43 2.14e-16 Alzheimer's disease; LUSC cis rs9393777 0.623 rs34313099 chr6:26489607 C/T cg09904177 chr6:26538194 HMGN4 -0.53 -5.9 -0.31 8.95e-9 Intelligence (multi-trait analysis); LUSC cis rs10779751 0.734 rs1130683 chr1:11132217 G/A cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs12908161 1.000 rs17601029 chr15:85347709 A/G cg17507749 chr15:85114479 UBE2QP1 0.53 6.57 0.34 1.94e-10 Schizophrenia; LUSC cis rs12776158 0.901 rs61848384 chr10:71215225 T/G cg12610070 chr10:71211762 TSPAN15 -0.46 -6.04 -0.31 4.07e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs2840044 1.000 rs225295 chr17:33925755 A/G cg19694781 chr19:47549865 TMEM160 -0.59 -9.38 -0.46 1.07e-18 Response to radiotherapy in cancer (late toxicity); LUSC cis rs16937 0.711 rs10900471 chr1:205173134 A/G cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15302128 chr10:104474204 SFXN2;ARL3 -0.42 -6.46 -0.33 3.73e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 14.15 0.61 6.38e-36 Platelet count; LUSC cis rs3741151 0.892 rs7107905 chr11:73061232 A/T cg17517138 chr11:73019481 ARHGEF17 0.85 8.03 0.4 1.63e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1371867 0.817 rs7846076 chr8:101327629 A/G cg06636551 chr8:101224915 SPAG1 -0.43 -8.06 -0.4 1.42e-14 Atrioventricular conduction; LUSC trans rs2562456 0.520 rs279793 chr19:21455774 C/T cg00806126 chr19:22604979 ZNF98 -0.43 -6.14 -0.32 2.37e-9 Pain; LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs4308124 0.708 rs2137168 chr2:111986509 C/T cg04571233 chr2:111982156 NA -0.53 -6.89 -0.35 2.82e-11 Vitiligo; LUSC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg18876405 chr7:65276391 NA -0.55 -8.77 -0.43 8.95e-17 Aortic root size; LUSC cis rs5758511 0.773 rs1894714 chr22:42349134 T/G cg00645731 chr22:42541494 CYP2D7P1 -0.44 -7.21 -0.37 3.78e-12 Birth weight; LUSC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.1 -0.41 1.05e-14 Intelligence (multi-trait analysis); LUSC cis rs601339 0.877 rs2649991 chr12:123179461 A/G cg11919336 chr12:123188078 GPR109A 0.43 6.52 0.34 2.64e-10 Adiponectin levels; LUSC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Parkinson's disease; LUSC cis rs748404 0.578 rs552701 chr15:43613810 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.46 6.32 0.33 8.46e-10 Lung cancer; LUSC cis rs11039100 1.000 rs11039110 chr11:5829111 A/G cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.33e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.1 -0.58 6.15e-32 Platelet count; LUSC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg18230493 chr5:56204884 C5orf35 0.5 7.86 0.4 5.2e-14 Coronary artery disease; LUSC cis rs4423214 1.000 rs3750997 chr11:71158841 A/C cg05163923 chr11:71159392 DHCR7 0.7 10.21 0.49 1.71e-21 Vitamin D levels; LUSC cis rs2219968 1.000 rs7465474 chr8:78959166 C/T cg00738934 chr8:78996279 NA 0.34 6.19 0.32 1.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2479724 0.625 rs9394835 chr6:41818200 A/T cg17623882 chr6:41773611 USP49 -0.49 -7.15 -0.36 5.63e-12 Menarche (age at onset); LUSC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg04053776 chr11:6947353 ZNF215 0.55 7.89 0.4 4.23e-14 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs9362426 1.000 rs9294377 chr6:88084839 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.39 6.19 0.32 1.8e-9 Depressive episodes in bipolar disorder; LUSC cis rs8018808 0.875 rs7250 chr14:77935520 G/A cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.94e-8 Myeloid white cell count; LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg05368731 chr17:41323189 NBR1 0.93 15.89 0.66 1.01e-42 Menopause (age at onset); LUSC cis rs71403859 0.685 rs12444890 chr16:71636026 G/A cg08717414 chr16:71523259 ZNF19 -0.74 -7.99 -0.4 2.26e-14 Post bronchodilator FEV1; LUSC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs694739 0.628 rs475032 chr11:64140737 G/C cg02228329 chr11:64053129 BAD;GPR137 -0.41 -5.94 -0.31 7.08e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs6733011 0.500 rs11123754 chr2:99433782 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.18 -0.32 1.92e-9 Bipolar disorder; LUSC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs9300255 0.568 rs1627724 chr12:123638580 T/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.17 -0.32 1.95e-9 Neutrophil percentage of white cells; LUSC cis rs1595825 0.838 rs80172713 chr2:198508044 T/C cg00982548 chr2:198649783 BOLL -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis; LUSC cis rs6062509 0.965 rs4809330 chr20:62349586 A/G cg01176363 chr20:62369445 LIME1 -0.46 -6.94 -0.35 2.09e-11 Prostate cancer; LUSC cis rs12464559 0.522 rs6759419 chr2:152549703 G/A cg01189475 chr2:152685088 ARL5A 0.63 5.65 0.3 3.42e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg05625103 chr10:2543513 NA 0.38 5.83 0.3 1.33e-8 Age-related hearing impairment; LUSC cis rs7577851 0.548 rs59129812 chr2:69656354 T/C cg10773587 chr2:69614142 GFPT1 0.52 5.71 0.3 2.48e-8 Parkinson's disease (age of onset); LUSC cis rs11051970 0.918 rs12229856 chr12:32531220 C/T cg24626660 chr12:32551988 NA 0.37 6.12 0.32 2.66e-9 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs61931739 0.500 rs7484658 chr12:34515879 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.09 0.45 9.21e-18 Morning vs. evening chronotype; LUSC cis rs11622475 1.000 rs2269186 chr14:104379912 C/T cg12183467 chr14:104352244 NA -0.45 -8.06 -0.4 1.36e-14 Bipolar disorder; LUSC cis rs11098499 0.863 rs28718422 chr4:120466304 C/A cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.66e-25 Corneal astigmatism; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15981295 chr2:62081471 FAM161A 0.4 6.15 0.32 2.17e-9 Triglycerides; LUSC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.62 -7.89 -0.4 4.43e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.91 -0.4 3.77e-14 Blood metabolite levels; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg24503407 chr1:205819492 PM20D1 -0.8 -15.51 -0.65 2.94e-41 Monocyte percentage of white cells; LUSC cis rs13082711 0.911 rs6789539 chr3:27444076 T/A cg02860705 chr3:27208620 NA 0.48 8.32 0.41 2.29e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs17255340 0.539 rs3778206 chr6:84058013 G/A cg08257003 chr6:84140564 ME1 0.34 8.23 0.41 4.23e-15 Platelet-derived growth factor BB levels; LUSC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg13395646 chr4:1353034 KIAA1530 -0.59 -9.25 -0.45 2.72e-18 Longevity; LUSC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg05585544 chr11:47624801 NA -0.42 -7.6 -0.38 2.95e-13 Subjective well-being; LUSC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.91 -0.35 2.41e-11 Coronary artery disease; LUSC cis rs10465746 0.780 rs1871924 chr1:84398466 T/A cg10977910 chr1:84465055 TTLL7 0.46 6.73 0.35 7.53e-11 Obesity-related traits; LUSC trans rs9329221 0.572 rs4841295 chr8:10105115 C/T cg15556689 chr8:8085844 FLJ10661 0.53 7.73 0.39 1.31e-13 Neuroticism; LUSC cis rs7666738 0.716 rs6814353 chr4:99074202 A/G cg05340658 chr4:99064831 C4orf37 0.65 10.93 0.51 5.72e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg13736514 chr6:26305472 NA -0.47 -9.19 -0.45 4.35e-18 Educational attainment; LUSC cis rs55665837 1.000 rs4412729 chr11:14439000 A/G cg19336497 chr11:14380999 RRAS2 -0.38 -7.5 -0.38 5.91e-13 Vitamin D levels; LUSC cis rs911119 0.913 rs4815222 chr20:23576964 A/G cg16589663 chr20:23618590 CST3 -0.6 -7.04 -0.36 1.11e-11 Chronic kidney disease; LUSC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.35 0.49 5.72e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7705502 1.000 rs72812832 chr5:173372625 G/A cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.3e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg04450456 chr4:17643702 FAM184B 0.39 6.6 0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6987853 0.563 rs7004796 chr8:42450170 T/G cg09913449 chr8:42400586 C8orf40 0.4 6.7 0.34 9.1e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg22800045 chr5:56110881 MAP3K1 0.46 6.17 0.32 1.96e-9 Coronary artery disease; LUSC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg25204440 chr1:209979598 IRF6 0.49 5.74 0.3 2.14e-8 Cleft lip with or without cleft palate; LUSC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg15595755 chr5:1867978 NA 0.47 8.6 0.43 3.12e-16 Cardiovascular disease risk factors; LUSC cis rs12042938 0.507 rs2570408 chr1:231732934 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.68 -0.5 4.34e-23 Neuranatomic and neurocognitive phenotypes; LUSC cis rs28830936 0.966 rs3743024 chr15:42118971 A/G cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.92 -0.31 7.95e-9 Diastolic blood pressure; LUSC trans rs8072100 0.967 rs8075411 chr17:45676760 C/T cg04995722 chr7:26192034 NFE2L3 0.37 6.15 0.32 2.24e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7267979 1.000 rs4815408 chr20:25346678 C/T cg08601574 chr20:25228251 PYGB -0.44 -6.79 -0.35 5.29e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -11.08 -0.52 1.61e-24 Alzheimer's disease; LUSC cis rs1524927 1.000 rs12704875 chr7:96341385 G/A cg03808172 chr7:96339361 SHFM1 0.43 6.66 0.34 1.12e-10 Total body bone mineral density; LUSC trans rs975739 0.868 rs5351 chr13:78475313 C/T cg15657206 chr11:10772781 CTR9 -0.36 -6.06 -0.31 3.66e-9 Hair color; LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg06387496 chr7:2775674 GNA12 -0.37 -5.72 -0.3 2.34e-8 Height; LUSC cis rs40363 1.000 rs37769 chr16:3514580 C/G cg00484396 chr16:3507460 NAT15 0.86 11.33 0.53 2.21e-25 Tuberculosis; LUSC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs12289510 0.539 rs3808995 chr11:124955977 A/G cg03868193 chr11:124958746 SLC37A2 0.59 9.19 0.45 4.22e-18 Platelet-derived growth factor BB levels; LUSC cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg12935359 chr14:103987150 CKB -0.51 -7.89 -0.4 4.39e-14 Body mass index; LUSC cis rs7103648 0.669 rs7131262 chr11:47836302 T/A cg20307385 chr11:47447363 PSMC3 0.81 11.79 0.54 4.49e-27 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs4820294 0.669 rs12628135 chr22:38065655 A/G cg21798802 chr22:38057573 PDXP 0.35 7.25 0.37 2.91e-12 Fat distribution (HIV); LUSC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg13206674 chr6:150067644 NUP43 0.61 9.71 0.47 8.23e-20 Lung cancer; LUSC cis rs7399018 0.739 rs7399073 chr12:51614050 C/A cg12163867 chr12:51592794 POU6F1 -0.46 -8.4 -0.42 1.27e-15 Cisplatin-induced ototoxicity; LUSC cis rs72634258 0.891 rs404381 chr1:8080745 C/T cg26816564 chr1:7831052 VAMP3 0.47 6.38 0.33 5.83e-10 Inflammatory bowel disease; LUSC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.74 0.63 3.2e-38 Platelet count; LUSC cis rs2439831 0.850 rs7169988 chr15:44060435 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.81 0.43 6.73e-17 Lung cancer in ever smokers; LUSC trans rs61931739 0.534 rs10844791 chr12:34211659 C/T cg26384229 chr12:38710491 ALG10B 0.74 12.07 0.55 4.31e-28 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg16606324 chr3:10149918 C3orf24 0.68 9.98 0.48 1.06e-20 Alzheimer's disease; LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg10862848 chr6:42927986 GNMT -0.28 -6.58 -0.34 1.83e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7772486 0.712 rs1292335 chr6:145967877 G/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.73 -0.3 2.24e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs12545109 0.571 rs1370306 chr8:57299137 C/G cg09654669 chr8:57350985 NA -0.45 -5.98 -0.31 5.7e-9 Obesity-related traits; LUSC cis rs10193935 0.901 rs6713242 chr2:42470794 C/T cg27598129 chr2:42591480 NA -0.63 -7.45 -0.38 8.04e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg27279351 chr12:120934652 DYNLL1 0.62 8.23 0.41 4.34e-15 High light scatter reticulocyte count; LUSC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg12257692 chr3:49977190 RBM6 0.24 6.43 0.33 4.41e-10 Body mass index; LUSC cis rs1577917 0.655 rs6454472 chr6:86224053 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 7.1 0.36 7.47e-12 Response to antipsychotic treatment; LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg07507251 chr3:52567010 NT5DC2 0.38 7.83 0.39 6.61e-14 Electroencephalogram traits; LUSC cis rs3540 0.533 rs2256097 chr15:90971331 A/T cg22089800 chr15:90895588 ZNF774 0.65 10.24 0.49 1.41e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg20650035 chr12:29542837 NA -0.45 -6.01 -0.31 4.85e-9 Thyroid stimulating hormone; LUSC cis rs9815354 0.812 rs55682201 chr3:41848497 A/G cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4295623 0.585 rs34421088 chr8:11589042 A/G cg21775007 chr8:11205619 TDH -0.47 -6.72 -0.35 7.66e-11 Morning vs. evening chronotype; LUSC cis rs4664308 0.967 rs7563607 chr2:160910215 C/G cg03641300 chr2:160917029 PLA2R1 -0.67 -11.33 -0.53 2.16e-25 Idiopathic membranous nephropathy; LUSC cis rs3749237 0.964 rs35210174 chr3:49812606 C/T cg03060546 chr3:49711283 APEH 0.59 8.31 0.41 2.5e-15 Resting heart rate; LUSC cis rs34779708 0.966 rs11010122 chr10:35493518 A/C cg03585969 chr10:35415529 CREM 0.64 9.53 0.46 3.25e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.59 8.81 0.43 6.86e-17 Hip circumference adjusted for BMI; LUSC cis rs8102476 0.703 rs4803899 chr19:38727640 A/T cg14131526 chr19:38747285 PPP1R14A 0.33 5.93 0.31 7.39e-9 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs1005277 0.638 rs1005278 chr10:38218748 G/A cg25427524 chr10:38739819 LOC399744 0.56 8.71 0.43 1.48e-16 Extrinsic epigenetic age acceleration; LUSC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg27211696 chr2:191398769 TMEM194B -0.61 -11.76 -0.54 5.82e-27 Pulse pressure; LUSC cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.04 -0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18231159 chr7:99214508 ZNF498 -0.49 -6.27 -0.32 1.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs9325144 0.560 rs1601745 chr12:38647828 G/A cg26384229 chr12:38710491 ALG10B -0.67 -10.52 -0.5 1.46e-22 Morning vs. evening chronotype; LUSC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg08564027 chr20:61660810 NA 0.9 17.32 0.69 2.14e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs7107174 1.000 rs10899457 chr11:78001163 T/A cg02023728 chr11:77925099 USP35 0.48 6.84 0.35 3.87e-11 Testicular germ cell tumor; LUSC cis rs752010 0.574 rs2148636 chr1:42119844 C/T cg06885757 chr1:42089581 HIVEP3 -0.45 -9.65 -0.47 1.34e-19 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg12419862 chr22:24373484 LOC391322 -1.0 -19.21 -0.72 6.09e-56 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs354225 0.584 rs11898033 chr2:54821518 G/A cg26097391 chr2:54893211 SPTBN1 0.41 6.27 0.32 1.12e-9 Schizophrenia; LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs6752107 1.000 rs12994997 chr2:234173503 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.6 0.54 2.35e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.83 -0.47 3.42e-20 Chronic sinus infection; LUSC trans rs10838798 0.504 rs10838852 chr11:48286256 C/T cg03929089 chr4:120376271 NA -0.44 -6.06 -0.31 3.68e-9 Height; LUSC cis rs2639990 1.000 rs632157 chr18:72911548 G/A cg02750262 chr18:72916776 ZADH2 0.69 7.65 0.39 2.14e-13 Vascular endothelial growth factor levels; LUSC cis rs4242434 0.927 rs57594397 chr8:22475657 T/C cg03733263 chr8:22462867 KIAA1967 0.99 17.75 0.7 4.21e-50 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs9443645 0.507 rs9343814 chr6:79473073 C/G cg05283184 chr6:79620031 NA -0.38 -7.02 -0.36 1.25e-11 Intelligence (multi-trait analysis); LUSC cis rs977987 0.771 rs4888387 chr16:75389755 T/G cg03315344 chr16:75512273 CHST6 0.51 9.71 0.47 8.39e-20 Dupuytren's disease; LUSC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg14773178 chr5:1868261 NA 0.33 6.12 0.32 2.56e-9 Cardiovascular disease risk factors; LUSC cis rs4363385 0.693 rs418550 chr1:153048045 A/T cg00922841 chr1:152955080 SPRR1A -0.42 -7.18 -0.37 4.6e-12 Inflammatory skin disease; LUSC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg03538708 chr1:25844672 NA -0.36 -5.96 -0.31 6.51e-9 Erythrocyte sedimentation rate; LUSC cis rs950169 0.887 rs12903946 chr15:84954430 T/C cg17173187 chr15:85201210 NMB 0.37 6.4 0.33 5.31e-10 Schizophrenia; LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg18404041 chr3:52824283 ITIH1 -0.69 -13.09 -0.58 7.01e-32 Bipolar disorder; LUSC cis rs72781680 0.848 rs56021814 chr2:24073437 T/A cg08917208 chr2:24149416 ATAD2B 0.87 9.91 0.48 1.8899999999999998e-20 Lymphocyte counts; LUSC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg05754148 chr16:3507555 NAT15 0.52 7.82 0.39 6.97e-14 Tuberculosis; LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg18477163 chr1:228402036 OBSCN -0.58 -10.89 -0.51 7.96e-24 Diastolic blood pressure; LUSC cis rs3105593 0.575 rs3098174 chr15:50778853 C/T cg08437265 chr15:50716283 USP8 0.41 5.9 0.31 8.98e-9 QT interval; LUSC cis rs861020 0.771 rs629150 chr1:209998467 C/T cg09163369 chr1:210001066 C1orf107 0.57 6.7 0.34 8.8e-11 Orofacial clefts; LUSC cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg13390004 chr1:15929781 NA 0.44 7.32 0.37 1.87e-12 Systolic blood pressure; LUSC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.27 -0.32 1.09e-9 Lung cancer; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg08888203 chr3:10149979 C3orf24 0.59 8.22 0.41 4.45e-15 Alzheimer's disease; LUSC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg10755058 chr3:40428713 ENTPD3 0.37 5.99 0.31 5.42e-9 Renal cell carcinoma; LUSC cis rs3540 0.576 rs10152871 chr15:91047469 G/A cg22089800 chr15:90895588 ZNF774 -0.63 -9.45 -0.46 6.21e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs427394 0.659 rs419128 chr5:6739791 G/A cg10857441 chr5:6722123 POLS -0.44 -8.11 -0.41 9.83e-15 Menopause (age at onset); LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 13.25 0.59 1.72e-32 Alzheimer's disease; LUSC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg02753203 chr1:228287806 NA -0.65 -10.96 -0.51 4.35e-24 Diastolic blood pressure; LUSC cis rs34779708 0.966 rs17499247 chr10:35426755 A/G cg03585969 chr10:35415529 CREM 0.6 8.97 0.44 2.11e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.73 0.39 1.3e-13 Eosinophil percentage of white cells; LUSC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg16850897 chr7:100343110 ZAN -0.6 -8.3 -0.41 2.61e-15 Other erythrocyte phenotypes; LUSC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg22549504 chr19:17448937 GTPBP3 0.57 7.28 0.37 2.45e-12 Systemic lupus erythematosus; LUSC cis rs6714710 0.535 rs13006932 chr2:98370698 T/A cg26665480 chr2:98280029 ACTR1B 0.63 9.15 0.45 5.81e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg24739457 chr1:205821442 NA 0.36 6.19 0.32 1.72e-9 Menarche (age at onset); LUSC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.29e-11 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs1595825 0.786 rs77218291 chr2:198565011 A/G cg00982548 chr2:198649783 BOLL -0.55 -7.05 -0.36 1.03e-11 Ulcerative colitis; LUSC trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg20587970 chr11:113659929 NA -1.27 -17.75 -0.7 4.04e-50 Hip circumference adjusted for BMI; LUSC trans rs7824557 0.564 rs2736301 chr8:11236413 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.54 -0.38 4.51e-13 Retinal vascular caliber; LUSC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs2408955 0.500 rs12816820 chr12:48558325 A/G cg24011408 chr12:48396354 COL2A1 0.4 5.8 0.3 1.55e-8 Glycated hemoglobin levels; LUSC trans rs12579753 0.956 rs11115039 chr12:82217338 A/C cg07923666 chr12:49932857 KCNH3 -0.51 -6.3 -0.33 9.31e-10 Resting heart rate; LUSC cis rs6547741 0.775 rs11692692 chr2:27861707 G/A cg27432699 chr2:27873401 GPN1 -0.89 -17.47 -0.69 5.44e-49 Oral cavity cancer; LUSC cis rs17125944 0.615 rs1998777 chr14:53295706 C/T cg00686598 chr14:53173677 PSMC6 -0.69 -6.73 -0.35 7.49e-11 Alzheimer's disease (late onset); LUSC trans rs877282 0.947 rs7904978 chr10:768078 C/T cg13042288 chr15:90349979 ANPEP -0.49 -7.08 -0.36 8.35e-12 Uric acid levels; LUSC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.1 0.48 4.16e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs929354 0.772 rs3802117 chr7:156987000 C/T cg05182265 chr7:156933206 UBE3C -0.59 -9.56 -0.46 2.61e-19 Body mass index; LUSC cis rs72634258 0.945 rs34466510 chr1:8147412 T/C cg26816564 chr1:7831052 VAMP3 0.48 5.87 0.31 1.08e-8 Inflammatory bowel disease; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg12419862 chr22:24373484 LOC391322 -0.86 -14.05 -0.61 1.52e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg18880390 chr1:175162128 KIAA0040 0.45 6.13 0.32 2.48e-9 Cognitive function;Information processing speed; LUSC trans rs1994135 0.617 rs12821909 chr12:33723466 T/C cg13010199 chr12:38710504 ALG10B 0.55 7.61 0.38 2.91e-13 Resting heart rate; LUSC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg13114125 chr14:105738426 BRF1 -0.9 -15.48 -0.65 3.89e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs3892630 0.588 rs2112917 chr19:33317543 C/T cg22980127 chr19:33182716 NUDT19 0.9 13.06 0.58 9.02e-32 Red blood cell traits; LUSC cis rs6541297 0.555 rs910502 chr1:230294185 A/T cg05784532 chr1:230284198 GALNT2 0.59 6.51 0.34 2.7e-10 Coronary artery disease; LUSC cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg00071950 chr4:10020882 SLC2A9 0.66 11.13 0.52 1.13e-24 Bone mineral density; LUSC cis rs2820315 1.000 rs2494114 chr1:201801011 C/G cg10061532 chr1:201886748 LMOD1 0.25 5.7 0.3 2.68e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg13683864 chr3:40499215 RPL14 -0.94 -15.82 -0.65 1.87e-42 Renal cell carcinoma; LUSC trans rs877282 0.945 rs10904555 chr10:787740 C/A cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg16743903 chr16:89593216 SPG7 -0.38 -5.81 -0.3 1.43e-8 Multiple myeloma (IgH translocation); LUSC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg15468180 chr1:107600409 PRMT6 0.36 5.92 0.31 7.8e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs4805272 0.512 rs12373558 chr19:29337692 A/G cg12667521 chr19:29218732 NA 0.51 6.08 0.32 3.35e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs208520 0.690 rs4386800 chr6:66755242 A/G cg07460842 chr6:66804631 NA 1.09 17.23 0.69 4.89e-48 Exhaled nitric oxide output; LUSC trans rs272594 0.614 rs420304 chr8:81475569 A/G cg01004056 chr1:230560318 NA -0.49 -6.5 -0.34 2.93e-10 Neutrophil count; LUSC cis rs9905704 0.647 rs7221274 chr17:57008128 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.35 -0.37 1.51e-12 Testicular germ cell tumor; LUSC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.85 0.3 1.2e-8 Tonsillectomy; LUSC cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.4 0.56 2.57e-29 Motion sickness; LUSC cis rs12497850 1.000 rs6788650 chr3:48749543 T/C cg07636037 chr3:49044803 WDR6 0.94 15.65 0.65 8.63e-42 Parkinson's disease; LUSC cis rs62458065 0.850 rs10273165 chr7:32460840 G/A cg20159608 chr7:32802032 NA -0.64 -7.57 -0.38 3.72e-13 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC trans rs1459104 0.571 rs10459012 chr11:55091574 C/A cg15704280 chr7:45808275 SEPT13 0.57 6.39 0.33 5.57e-10 Body mass index; LUSC cis rs17270561 0.583 rs9393661 chr6:25739080 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg19230755 chr7:65878503 NA -0.43 -6.02 -0.31 4.48e-9 Aortic root size; LUSC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg26597838 chr10:835615 NA 0.98 13.46 0.59 2.73e-33 Eosinophil percentage of granulocytes; LUSC cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -9.37 -0.46 1.15e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs72781680 0.898 rs72786286 chr2:24074659 T/A cg20701182 chr2:24300061 SF3B14 0.55 5.83 0.3 1.28e-8 Lymphocyte counts; LUSC cis rs2309752 1 rs2309752 chr2:100762169 T/A cg22139774 chr2:100720529 AFF3 -0.52 -9.11 -0.45 7.58e-18 Intelligence (multi-trait analysis); LUSC cis rs1577917 1.000 rs12192992 chr6:86609915 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs55883249 1.000 rs62119428 chr2:9743332 T/C cg23886495 chr2:9695866 ADAM17 0.49 5.78 0.3 1.71e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.83 0.35 3.93e-11 Lung cancer; LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg23283495 chr1:209979779 IRF6 0.64 7.74 0.39 1.2e-13 Cleft lip with or without cleft palate; LUSC cis rs8063160 0.740 rs35850949 chr16:89720724 C/A cg07984980 chr16:89898383 SPIRE2 0.85 6.4 0.33 5.27e-10 Red vs non-red hair color;Light vs. dark hair color;Brown vs. non-brown hair color; LUSC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg22920501 chr2:26401640 FAM59B -0.74 -10.5 -0.5 1.77e-22 Gut microbiome composition (summer); LUSC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC trans rs12188164 0.965 rs72717438 chr5:448663 C/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg18681998 chr4:17616180 MED28 0.85 15.23 0.64 3.79e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg02527881 chr3:46936655 PTH1R 0.66 11.95 0.55 1.2100000000000001e-27 Birth weight; LUSC cis rs7267979 1.000 rs2482928 chr20:25331530 A/G cg08601574 chr20:25228251 PYGB -0.44 -6.8 -0.35 4.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg18131467 chr2:239335373 ASB1 1.03 25.05 0.81 1.11e-78 Multiple system atrophy; LUSC cis rs9527 0.590 rs7092029 chr10:104823909 A/T cg04362960 chr10:104952993 NT5C2 0.62 9.62 0.47 1.71e-19 Arsenic metabolism; LUSC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg01475377 chr6:109611718 NA -0.45 -8.27 -0.41 3.3e-15 Reticulocyte fraction of red cells; LUSC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs9921338 0.887 rs7189044 chr16:11442196 G/C cg00044050 chr16:11439710 C16orf75 -0.5 -6.73 -0.35 7.26e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs13082711 0.911 rs34981505 chr3:27437322 A/T cg02860705 chr3:27208620 NA 0.46 7.66 0.39 2e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg25894440 chr7:65020034 NA -0.37 -5.81 -0.3 1.44e-8 Calcium levels; LUSC cis rs9814567 0.712 rs4306900 chr3:134334327 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.78 12.56 0.57 6.86e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg13256891 chr4:100009986 ADH5 0.49 6.25 0.32 1.27e-9 Alcohol dependence; LUSC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg18904891 chr8:8559673 CLDN23 0.61 8.43 0.42 1.02e-15 Obesity-related traits; LUSC cis rs6964587 0.900 rs7783674 chr7:91784212 T/A cg01689657 chr7:91764605 CYP51A1 0.32 5.91 0.31 8.67e-9 Breast cancer; LUSC cis rs929354 0.713 rs6459733 chr7:156930550 G/C cg05182265 chr7:156933206 UBE3C -0.58 -9.02 -0.44 1.46e-17 Body mass index; LUSC cis rs6489882 0.836 rs12322160 chr12:113368505 A/G cg20102336 chr12:113376681 OAS3 -0.42 -6.13 -0.32 2.44e-9 Chronic lymphocytic leukemia; LUSC cis rs9902453 0.868 rs9890075 chr17:28470464 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.13 0.45 6.89e-18 Coffee consumption (cups per day); LUSC trans rs17507216 0.958 rs28648832 chr15:83236392 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.45 -6.2 -0.32 1.68e-9 Excessive daytime sleepiness; LUSC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg05535760 chr7:792225 HEATR2 -0.73 -7.33 -0.37 1.7e-12 Cerebrospinal P-tau181p levels; LUSC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg01097406 chr16:89675127 NA -0.47 -9.78 -0.47 4.84e-20 Vitiligo; LUSC trans rs208520 0.690 rs207118 chr6:66788948 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg00484396 chr16:3507460 NAT15 0.88 11.54 0.53 3.68e-26 Tuberculosis; LUSC cis rs644799 0.610 rs1255179 chr11:95472097 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.49 6.98 0.36 1.63e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9314323 0.964 rs2304300 chr8:26249018 G/A cg13160058 chr8:26243215 BNIP3L -0.42 -7.53 -0.38 4.82e-13 Red cell distribution width; LUSC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg11062466 chr8:58055876 NA 0.55 7.63 0.39 2.45e-13 Developmental language disorder (linguistic errors); LUSC cis rs3126085 0.877 rs4457589 chr1:152247860 T/C cg26876637 chr1:152193138 HRNR 0.45 6.03 0.31 4.34e-9 Atopic dermatitis; LUSC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg01448562 chr3:133502909 NA 0.68 10.99 0.52 3.51e-24 Iron status biomarkers; LUSC cis rs4253772 0.678 rs1055659 chr22:46638298 C/T cg24881330 chr22:46731750 TRMU 0.54 6.17 0.32 1.94e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs9300255 0.568 rs1047158 chr12:123644056 C/A cg00376283 chr12:123451042 ABCB9 0.67 8.44 0.42 9.73e-16 Neutrophil percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14095692 chr18:8707237 NA 0.4 6.05 0.31 3.93e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg05025164 chr4:1340916 KIAA1530 0.42 6.35 0.33 7.2e-10 Longevity; LUSC cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg23788917 chr6:8435910 SLC35B3 -0.51 -7.49 -0.38 6.2800000000000005e-13 Motion sickness; LUSC cis rs8017423 0.967 rs28424204 chr14:90705669 G/C cg04374321 chr14:90722782 PSMC1 0.73 11.56 0.53 3.22e-26 Mortality in heart failure; LUSC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7771547 0.519 rs12202691 chr6:36377820 G/A cg07856975 chr6:36356162 ETV7 0.45 6.53 0.34 2.44e-10 Platelet distribution width; LUSC trans rs7824557 0.527 rs2572448 chr8:11239352 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -7.41 -0.38 1.04e-12 Retinal vascular caliber; LUSC cis rs2692947 0.695 rs12464148 chr2:96596710 G/C cg22654517 chr2:96458247 NA 0.34 6.82 0.35 4.29e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg12219531 chr12:120966889 COQ5 0.67 9.24 0.45 2.95e-18 High light scatter reticulocyte count; LUSC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg12365402 chr11:9010492 NRIP3 -0.44 -8.24 -0.41 3.89e-15 Hemoglobin concentration; LUSC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg11965913 chr1:205819406 PM20D1 0.48 6.84 0.35 3.86e-11 Parkinson's disease; LUSC cis rs5753618 0.539 rs8135344 chr22:31671932 G/T cg22777020 chr22:31556080 RNF185 -0.46 -5.87 -0.31 1.04e-8 Colorectal cancer; LUSC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12667521 chr19:29218732 NA 0.63 9.05 0.44 1.18e-17 Methadone dose in opioid dependence; LUSC cis rs668210 0.793 rs619701 chr11:65772080 G/A cg04700828 chr11:65773979 NA 0.4 5.82 0.3 1.41e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs6469656 0.892 rs4645587 chr8:117651760 C/T cg24004040 chr8:117650383 NA -0.42 -6.12 -0.32 2.69e-9 Colorectal cancer; LUSC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg16145915 chr7:1198662 ZFAND2A 0.43 6.34 0.33 7.35e-10 Bronchopulmonary dysplasia; LUSC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.71 -9.21 -0.45 3.81e-18 Gut microbiome composition (summer); LUSC cis rs7107174 1.000 rs2256051 chr11:77920457 G/A cg02023728 chr11:77925099 USP35 0.49 7.17 0.37 4.73e-12 Testicular germ cell tumor; LUSC cis rs765787 0.530 rs12913123 chr15:45516425 C/T cg25801113 chr15:45476975 SHF -0.32 -6.45 -0.33 3.89e-10 Uric acid levels; LUSC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg05855489 chr10:104503620 C10orf26 -0.69 -10.18 -0.49 2.31e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg04455712 chr21:45112962 RRP1B 0.45 8.63 0.43 2.55e-16 Mean corpuscular volume; LUSC cis rs2692947 0.727 rs893173 chr2:96789787 T/C cg23100626 chr2:96804247 ASTL 0.28 7.05 0.36 1.04e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13679077 chr7:22862647 TOMM7 -0.46 -7.05 -0.36 1.06e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs12579753 0.917 rs7138533 chr12:82187885 C/G cg07923666 chr12:49932857 KCNH3 -0.5 -6.26 -0.32 1.16e-9 Resting heart rate; LUSC cis rs477692 0.789 rs507900 chr10:131398144 A/G cg05714579 chr10:131428358 MGMT -0.48 -7.01 -0.36 1.36e-11 Response to temozolomide; LUSC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg05368731 chr17:41323189 NBR1 0.93 15.96 0.66 5.28e-43 Menopause (age at onset); LUSC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg25754956 chr12:51612065 POU6F1 0.98 13.5 0.59 1.87e-33 Cisplatin-induced ototoxicity; LUSC cis rs60015123 0.850 rs58845597 chr12:7120942 T/C cg26269324 chr12:6977084 TPI1 0.77 5.82 0.3 1.36e-8 Red cell distribution width; LUSC cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.6 -8.43 -0.42 1.05e-15 Systemic lupus erythematosus; LUSC cis rs9677476 0.863 rs58067379 chr2:232088295 A/T cg07929768 chr2:232055508 NA 0.34 6.53 0.34 2.5e-10 Food antigen IgG levels; LUSC cis rs1519814 0.876 rs10955954 chr8:121108052 A/G cg22335954 chr8:121166405 COL14A1 -0.41 -5.65 -0.3 3.44e-8 Breast cancer; LUSC cis rs798766 1.000 rs1665366 chr4:1728381 A/G cg05874882 chr4:1763078 NA 0.58 9.3 0.45 1.85e-18 Bladder cancer;Urinary bladder cancer; LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg16393715 chr7:1948819 MAD1L1 0.37 6.34 0.33 7.41e-10 Bipolar disorder and schizophrenia; LUSC cis rs8141529 0.636 rs5762813 chr22:29203314 C/T cg02153584 chr22:29168773 CCDC117 0.53 6.79 0.35 5.07e-11 Lymphocyte counts; LUSC cis rs7582720 1.000 rs72934737 chr2:203740798 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs7618501 0.633 rs4688758 chr3:50028385 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.92 0.44 3.12e-17 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.913 rs12363722 chr11:68236291 A/C cg16797656 chr11:68205561 LRP5 0.37 6.14 0.32 2.34e-9 Total body bone mineral density; LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg17971929 chr21:40555470 PSMG1 0.78 13.04 0.58 1.06e-31 Cognitive function; LUSC cis rs11676348 0.772 rs12471105 chr2:218950209 G/A cg00012203 chr2:219082015 ARPC2 -0.5 -7.65 -0.39 2.21e-13 Ulcerative colitis; LUSC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg11764359 chr7:65958608 NA -0.68 -10.5 -0.5 1.84e-22 Aortic root size; LUSC cis rs17102423 0.559 rs11627382 chr14:65480208 A/G cg11161011 chr14:65562177 MAX -0.64 -8.87 -0.44 4.49e-17 Obesity-related traits; LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs6840360 0.615 rs7669761 chr4:152609304 G/A cg22705602 chr4:152727874 NA -0.35 -7.69 -0.39 1.68e-13 Intelligence (multi-trait analysis); LUSC cis rs12681288 0.550 rs12674921 chr8:957969 A/C cg15309053 chr8:964076 NA 0.42 8.66 0.43 2.11e-16 Schizophrenia; LUSC cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg00101154 chr16:420108 MRPL28 0.52 9.22 0.45 3.43e-18 Bone mineral density (spine);Bone mineral density; LUSC cis rs7647973 0.696 rs3087866 chr3:49054692 A/G cg21141812 chr3:48556323 PFKFB4 0.37 6.33 0.33 7.98e-10 Menarche (age at onset); LUSC trans rs2288327 0.673 rs35504893 chr2:179421294 C/T cg14011486 chr1:26737247 LIN28 0.53 7.02 0.36 1.26e-11 Atrial fibrillation; LUSC cis rs7824557 0.603 rs11250130 chr8:11214455 C/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.14 -0.32 2.36e-9 Retinal vascular caliber; LUSC cis rs11971779 0.715 rs10954646 chr7:139061069 C/G cg07862535 chr7:139043722 LUC7L2 -0.54 -7.0 -0.36 1.38e-11 Diisocyanate-induced asthma; LUSC trans rs800082 0.839 rs11714177 chr3:144312862 T/C cg24215973 chr2:240111563 HDAC4 -0.44 -6.54 -0.34 2.29e-10 Smoking behavior; LUSC cis rs11098499 0.697 rs35280960 chr4:120257059 G/A cg09307838 chr4:120376055 NA 0.69 10.4 0.49 3.82e-22 Corneal astigmatism; LUSC trans rs11098499 0.657 rs4463052 chr4:120313258 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05901451 chr6:126070800 HEY2 0.58 9.29 0.45 2.09e-18 Endometrial cancer; LUSC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg13939156 chr17:80058883 NA -0.33 -6.6 -0.34 1.59e-10 Life satisfaction; LUSC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg16928487 chr17:17741425 SREBF1 -0.43 -8.55 -0.42 4.5e-16 Total body bone mineral density; LUSC cis rs7617773 0.780 rs13084616 chr3:48339699 A/G cg20734569 chr3:48348370 SPINK8 0.45 7.88 0.4 4.6e-14 Coronary artery disease; LUSC cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.59 -0.46 2.18e-19 Chronic sinus infection; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09555414 chr11:57520668 BTBD18 -0.72 -5.98 -0.31 5.68e-9 Cognitive performance; LUSC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.06 -0.31 3.74e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3740713 0.669 rs61736803 chr11:18422487 C/A cg23797887 chr11:18477753 LDHAL6A -0.49 -5.86 -0.31 1.09e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg15448220 chr1:150897856 SETDB1 0.44 6.49 0.33 3.08e-10 Melanoma; LUSC cis rs3540 0.574 rs2601205 chr15:90961813 A/G cg04176472 chr15:90893244 GABARAPL3 0.33 5.98 0.31 5.61e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6424115 0.965 rs2502979 chr1:24149315 C/A cg15997130 chr1:24165203 NA 0.54 8.82 0.43 6.62e-17 Immature fraction of reticulocytes; LUSC cis rs472402 0.580 rs6884552 chr5:6661966 C/T cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.55 -7.77 -0.39 9.82e-14 Response to amphetamines; LUSC cis rs6542838 0.583 rs12712040 chr2:99513416 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.18 -0.32 1.86e-9 Fear of minor pain; LUSC cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg20848291 chr7:100343083 ZAN 0.39 5.99 0.31 5.34e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg27398817 chr8:82754497 SNX16 0.66 8.41 0.42 1.18e-15 Diastolic blood pressure; LUSC trans rs800082 0.516 rs7622736 chr3:144229272 A/G cg24215973 chr2:240111563 HDAC4 0.46 6.92 0.35 2.37e-11 Smoking behavior; LUSC cis rs7617773 0.925 rs6442105 chr3:48182326 A/G cg11946769 chr3:48343235 NME6 -0.64 -9.47 -0.46 5.08e-19 Coronary artery disease; LUSC cis rs6674970 0.518 rs15740 chr1:151040435 G/A cg03258749 chr1:151040405 MLLT11 -0.62 -8.73 -0.43 1.27e-16 Childhood ear infection; LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -8.66 -0.43 2.09e-16 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs1577917 0.958 rs12192033 chr6:86472559 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.76 -0.43 1.02e-16 Response to antipsychotic treatment; LUSC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg02782426 chr3:40428986 ENTPD3 0.41 7.32 0.37 1.82e-12 Renal cell carcinoma; LUSC cis rs6580649 0.941 rs72644841 chr12:48411987 A/G cg24011408 chr12:48396354 COL2A1 -0.49 -6.62 -0.34 1.43e-10 Lung cancer; LUSC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.04 -0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs2742234 0.590 rs2435383 chr10:43675671 T/C cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs2404602 0.967 rs7167613 chr15:77041192 C/A cg26408565 chr15:76604113 ETFA -0.44 -6.86 -0.35 3.26e-11 Blood metabolite levels; LUSC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg03806693 chr22:41940476 POLR3H 1.04 14.71 0.63 4.1e-38 Vitiligo; LUSC cis rs4925386 0.808 rs1741634 chr20:60925979 A/C cg06026331 chr20:60912101 LAMA5 -0.43 -5.77 -0.3 1.78e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs9287719 0.967 rs2287062 chr2:10743191 G/A cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs4478858 0.735 rs4949384 chr1:31792141 A/G cg00250761 chr1:31883323 NA -0.37 -8.97 -0.44 2.17e-17 Alcohol dependence; LUSC cis rs2180341 0.640 rs11154395 chr6:127629138 T/C cg24812749 chr6:127587940 RNF146 0.66 9.92 0.48 1.74e-20 Breast cancer; LUSC cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg23711669 chr6:146136114 FBXO30 -0.92 -18.15 -0.7 1.02e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs6696846 0.765 rs2836 chr1:205111761 G/T cg21545522 chr1:205238299 TMCC2 -0.48 -9.08 -0.45 9.35e-18 Red blood cell count; LUSC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg22496339 chr2:162101262 NA 0.73 11.88 0.54 2.26e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg15383120 chr6:291909 DUSP22 0.44 6.91 0.35 2.4e-11 Menopause (age at onset); LUSC cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg11584989 chr19:19387371 SF4 0.58 7.02 0.36 1.22e-11 Bipolar disorder; LUSC cis rs4899554 0.640 rs4899555 chr14:75719834 T/C cg18117039 chr14:75741733 NA 0.53 7.11 0.36 7.04e-12 Inflammatory bowel disease; LUSC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.13 -0.45 6.61e-18 Gut microbiome composition (summer); LUSC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -6.53 -0.34 2.4e-10 Developmental language disorder (linguistic errors); LUSC cis rs4776059 1.000 rs1863512 chr15:52959687 C/T cg22715398 chr15:52968154 KIAA1370 -0.67 -9.6 -0.47 1.92e-19 Schizophrenia; LUSC cis rs4285028 0.948 rs2332033 chr3:121699548 C/T cg11130432 chr3:121712080 ILDR1 -0.65 -9.87 -0.48 2.52e-20 Multiple sclerosis; LUSC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg12927641 chr6:109611667 NA -0.43 -7.58 -0.38 3.41e-13 Reticulocyte fraction of red cells; LUSC cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.44e-12 Motion sickness; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg03790207 chr6:42947109 PEX6 -0.46 -6.98 -0.36 1.57e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12421382 0.659 rs60143378 chr11:109385513 T/C cg16359550 chr11:109292809 C11orf87 0.37 6.46 0.33 3.71e-10 Schizophrenia; LUSC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg23262073 chr20:60523788 NA -0.5 -7.14 -0.36 5.94e-12 Body mass index; LUSC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg03351412 chr1:154909251 PMVK 0.55 8.7 0.43 1.52e-16 Prostate cancer; LUSC cis rs6977660 0.562 rs2189566 chr7:19768960 G/A cg05791153 chr7:19748676 TWISTNB 0.92 9.51 0.46 4.04e-19 Thyroid stimulating hormone; LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg16362232 chr11:430036 ANO9 0.71 8.68 0.43 1.82e-16 Body mass index; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg07167872 chr1:205819463 PM20D1 0.99 23.0 0.78 8.03e-71 Menarche (age at onset); LUSC cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg23649088 chr2:200775458 C2orf69 -0.5 -6.86 -0.35 3.41e-11 Schizophrenia; LUSC cis rs55665837 1.000 rs10832257 chr11:14443316 A/G cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.35 0.37 1.56e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs921968 0.584 rs2305833 chr2:219305404 G/C cg02176678 chr2:219576539 TTLL4 0.57 9.93 0.48 1.54e-20 Mean corpuscular hemoglobin concentration; LUSC trans rs9951602 1.000 rs9949784 chr18:76649994 A/G cg02800362 chr5:177631904 HNRNPAB 1.01 10.99 0.52 3.48e-24 Obesity-related traits; LUSC cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg15997130 chr1:24165203 NA 0.5 8.37 0.42 1.63e-15 Immature fraction of reticulocytes; LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg18099408 chr3:52552593 STAB1 -0.41 -6.93 -0.35 2.12e-11 Bipolar disorder; LUSC cis rs11690935 0.959 rs11904009 chr2:172627343 T/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.37 -0.62 8.79e-37 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17431860 chr11:118966319 H2AFX -0.44 -6.83 -0.35 4.07e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4253772 0.530 rs28362161 chr22:46807439 C/T cg00784671 chr22:46762841 CELSR1 -0.55 -5.9 -0.31 8.78e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11890956 chr21:40555474 PSMG1 0.99 18.0 0.7 3.97e-51 Cognitive function; LUSC cis rs2303282 0.773 rs12918376 chr16:56558181 G/T cg00500540 chr16:56394104 NA 0.43 7.02 0.36 1.22e-11 Breast cancer; LUSC trans rs7681440 0.874 rs1372524 chr4:90776045 A/G cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.96 -0.31 6.49e-9 Dementia with Lewy bodies; LUSC cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg26384229 chr12:38710491 ALG10B 0.87 14.29 0.62 1.83e-36 Bladder cancer; LUSC cis rs911119 0.866 rs4346460 chr20:23569400 C/T cg16589663 chr20:23618590 CST3 0.63 7.33 0.37 1.74e-12 Chronic kidney disease; LUSC cis rs6060717 0.536 rs6060699 chr20:34523833 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -6.01 -0.31 4.81e-9 Hip circumference adjusted for BMI; LUSC cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg16339924 chr4:17578868 LAP3 0.55 8.17 0.41 6.53e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg03351412 chr1:154909251 PMVK 0.45 7.0 0.36 1.38e-11 Prostate cancer; LUSC cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg18252515 chr7:66147081 NA -1.19 -12.67 -0.57 2.71e-30 Diabetic kidney disease; LUSC cis rs34421088 0.532 rs2736388 chr8:11159588 T/C cg21775007 chr8:11205619 TDH 0.48 6.88 0.35 2.97e-11 Neuroticism; LUSC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg22800045 chr5:56110881 MAP3K1 0.43 5.83 0.3 1.3e-8 Coronary artery disease; LUSC cis rs1018697 0.518 rs2790914 chr10:104568018 C/T cg04362960 chr10:104952993 NT5C2 -0.72 -8.51 -0.42 5.89e-16 Colorectal adenoma (advanced); LUSC cis rs4474465 0.850 rs10793330 chr11:78269985 T/C cg27205649 chr11:78285834 NARS2 0.51 6.08 0.32 3.26e-9 Alzheimer's disease (survival time); LUSC trans rs11250098 0.547 rs2409764 chr8:11281273 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.05 0.4 1.51e-14 Morning vs. evening chronotype; LUSC cis rs8028313 0.609 rs28735117 chr15:67933892 C/T cg05925327 chr15:68127851 NA -0.38 -5.89 -0.31 9.25e-9 Obesity; LUSC cis rs826838 0.967 rs7963716 chr12:38876090 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.1 0.48 4.31e-21 Heart rate; LUSC cis rs4356932 0.967 rs10856873 chr4:76972924 T/G cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs11711311 0.955 rs10934241 chr3:113394705 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -5.97 -0.31 6.21e-9 IgG glycosylation; LUSC cis rs259282 0.524 rs731674 chr19:33132395 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.75 12.21 0.56 1.3e-28 Schizophrenia; LUSC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg27170947 chr2:26402098 FAM59B -0.65 -9.52 -0.46 3.75e-19 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg08677398 chr8:58056175 NA 0.52 7.15 0.36 5.67e-12 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg22875332 chr1:76189707 ACADM 0.66 8.43 0.42 1.06e-15 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6549438 1.000 rs6798993 chr3:72161623 A/C cg14550559 chr2:240039617 HDAC4 0.43 5.95 0.31 6.83e-9 Migraine - clinic-based; LUSC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg10802521 chr3:52805072 NEK4 -0.56 -9.11 -0.45 7.82e-18 Bipolar disorder; LUSC cis rs9311676 0.656 rs68021431 chr3:58403136 A/G cg13750441 chr3:58318267 PXK 0.34 6.55 0.34 2.19e-10 Systemic lupus erythematosus; LUSC cis rs11229555 0.645 rs12786744 chr11:58177549 T/C cg15696309 chr11:58395628 NA -0.66 -8.17 -0.41 6.33e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7589342 0.831 rs6731173 chr2:106522928 A/G cg16077055 chr2:106428750 NCK2 0.35 6.54 0.34 2.36e-10 Addiction; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg23034840 chr1:205782522 SLC41A1 -0.74 -12.33 -0.56 4.66e-29 Monocyte percentage of white cells; LUSC cis rs929596 0.517 rs1875263 chr2:234625622 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -8.74 -0.43 1.15e-16 Total bilirubin levels in HIV-1 infection; LUSC cis rs72781680 1.000 rs6731001 chr2:24192952 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg06671706 chr8:8559999 CLDN23 0.49 6.57 0.34 1.94e-10 Obesity-related traits; LUSC cis rs1044826 1.000 rs9834607 chr3:139234184 A/G cg00490450 chr3:139108681 COPB2 0.52 6.81 0.35 4.58e-11 Obesity-related traits; LUSC cis rs983392 0.679 rs636341 chr11:60019161 A/C cg24026212 chr11:59952134 MS4A6A 0.37 6.45 0.33 3.95e-10 Alzheimer's disease (late onset); LUSC trans rs705162 0.542 rs845102 chr10:125185442 C/T cg03174038 chr16:2134317 TSC2 -0.43 -6.06 -0.31 3.63e-9 Migraine; LUSC cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg08807101 chr21:30365312 RNF160 -0.69 -11.92 -0.55 1.54e-27 Dental caries; LUSC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg11764359 chr7:65958608 NA 0.71 10.7 0.51 3.64e-23 Aortic root size; LUSC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.03e-34 Prostate cancer; LUSC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg20476274 chr7:133979776 SLC35B4 0.86 16.48 0.67 4.59e-45 Mean platelet volume; LUSC cis rs36093844 0.605 rs79719453 chr11:85582217 C/A cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs41271473 0.948 rs12144495 chr1:228810937 G/T cg16512390 chr1:228756714 NA -0.52 -6.3 -0.33 9.2e-10 Chronic lymphocytic leukemia; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg00634984 chr7:65235879 NA 0.4 5.83 0.3 1.28e-8 Calcium levels; LUSC cis rs4704187 0.663 rs1422697 chr5:74445817 G/A cg03227963 chr5:74354835 NA 0.31 6.77 0.35 5.96e-11 Response to amphetamines; LUSC cis rs8060686 0.591 rs255054 chr16:68017356 A/G cg09835421 chr16:68378352 PRMT7 -0.55 -6.33 -0.33 8.08e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs1008375 0.835 rs9760627 chr4:17651508 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.54 0.34 2.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg06873352 chr17:61820015 STRADA 0.71 12.79 0.57 9.66e-31 Prudent dietary pattern; LUSC cis rs4356932 0.905 rs4859597 chr4:76956630 A/T cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs4919694 1.000 rs74749600 chr10:104732996 T/C cg04362960 chr10:104952993 NT5C2 1.16 13.56 0.6 1.16e-33 Arsenic metabolism; LUSC cis rs7904368 0.806 rs7099178 chr10:16862578 C/G cg14835575 chr10:16859367 RSU1 0.73 9.57 0.46 2.42e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.97 -17.67 -0.7 8.15e-50 Chronic sinus infection; LUSC cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg21252483 chr19:49399788 TULP2 -0.48 -6.77 -0.35 5.81e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.32e-11 Tonsillectomy; LUSC trans rs62458065 0.850 rs62458100 chr7:32473142 C/G cg00845942 chr12:64062724 DPY19L2 -0.53 -6.08 -0.32 3.33e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg01416388 chr22:39784598 NA -0.43 -7.17 -0.37 4.92e-12 Intelligence (multi-trait analysis); LUSC cis rs9925964 0.622 rs8046707 chr16:30916233 G/A cg02466173 chr16:30829666 NA 0.37 6.91 0.35 2.41e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg14664628 chr15:75095509 CSK -0.58 -9.06 -0.44 1.13e-17 Breast cancer; LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.4 -0.38 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9837602 1.000 rs6790877 chr3:99779658 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.37 5.72 0.3 2.4e-8 Breast cancer; LUSC cis rs568617 0.716 rs77779142 chr11:65599656 C/T cg19792802 chr11:65647270 CTSW 0.46 6.42 0.33 4.68e-10 Crohn's disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00827380 chr2:118572045 DDX18 0.37 5.97 0.31 6.11e-9 Triglycerides; LUSC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg12560992 chr17:57184187 TRIM37 -0.84 -15.43 -0.64 6.56e-41 Intelligence (multi-trait analysis); LUSC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg08704250 chr15:31115839 NA 0.59 9.38 0.46 1.08e-18 Huntington's disease progression; LUSC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg15556689 chr8:8085844 FLJ10661 -0.69 -10.29 -0.49 9.15e-22 Neuroticism; LUSC trans rs12210905 0.925 rs72838238 chr6:26971681 G/A cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC trans rs2204008 0.837 rs11180482 chr12:38235950 G/A cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.38e-9 Bladder cancer; LUSC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg18357645 chr12:58087776 OS9 -0.43 -6.13 -0.32 2.46e-9 Multiple sclerosis; LUSC cis rs2236521 0.617 rs2236520 chr20:60892172 T/C cg12382846 chr20:60892121 LAMA5 0.33 5.92 0.31 8.17e-9 Pelvic organ prolapse; LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg06600287 chr1:53387719 ECHDC2 0.31 6.24 0.32 1.35e-9 Monocyte count; LUSC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg08677398 chr8:58056175 NA 0.5 5.74 0.3 2.16e-8 Developmental language disorder (linguistic errors); LUSC cis rs12594515 0.967 rs11857628 chr15:45998206 C/T cg06207120 chr15:45996521 NA 0.39 6.03 0.31 4.46e-9 Waist circumference;Weight; LUSC cis rs9807989 0.507 rs3755266 chr2:103042712 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.92e-12 Asthma; LUSC trans rs1728785 1.000 rs1645938 chr16:68595197 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.22 0.41 4.57e-15 Ulcerative colitis; LUSC cis rs4356932 0.691 rs2242474 chr4:76878982 T/C cg00809888 chr4:76862425 NAAA -0.36 -5.72 -0.3 2.31e-8 Blood protein levels; LUSC cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.42 -5.79 -0.3 1.58e-8 Alzheimer's disease (late onset); LUSC cis rs1372520 0.577 rs2737028 chr4:90717016 A/G cg01966878 chr4:90757139 SNCA -0.4 -5.7 -0.3 2.7e-8 Neuroticism; LUSC cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.26 -0.37 2.73e-12 Bipolar disorder; LUSC cis rs7267979 0.844 rs869358 chr20:25374674 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -16.6 -0.67 1.46e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -7.78 -0.39 9.38e-14 Chronic sinus infection; LUSC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs77741769 0.926 rs61946386 chr12:121364025 T/C cg02403541 chr12:121454288 C12orf43 0.49 7.25 0.37 2.88e-12 Mean corpuscular volume; LUSC cis rs983392 0.679 rs600064 chr11:60013451 A/G cg24026212 chr11:59952134 MS4A6A 0.36 6.21 0.32 1.55e-9 Alzheimer's disease (late onset); LUSC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg21972741 chr5:435613 AHRR 0.34 6.42 0.33 4.6e-10 Cystic fibrosis severity; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg24626850 chr1:36615251 TRAPPC3 0.48 6.18 0.32 1.86e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7582180 0.715 rs764828 chr2:100908634 A/C cg08017756 chr2:100939284 LONRF2 -0.42 -7.71 -0.39 1.46e-13 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.908 rs138864 chr22:50204712 G/A cg08270630 chr22:50330655 NA -0.41 -6.27 -0.32 1.15e-9 Schizophrenia; LUSC cis rs1372520 0.684 rs1442144 chr4:90736113 T/C cg15133208 chr4:90757351 SNCA -0.54 -8.45 -0.42 9.03e-16 Neuroticism; LUSC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.8 -0.35 4.84e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7208859 0.524 rs11653098 chr17:29122501 C/T cg13385521 chr17:29058706 SUZ12P 0.66 6.31 0.33 8.81e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1448094 0.935 rs10746355 chr12:86330227 A/T cg18827107 chr12:86230957 RASSF9 -0.41 -6.01 -0.31 4.85e-9 Major depressive disorder; LUSC cis rs10883723 0.518 rs10786679 chr10:104315667 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -6.84 -0.35 3.86e-11 Allergic disease (asthma, hay fever or eczema); LUSC trans rs208520 0.779 rs208446 chr6:66903515 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.96 -12.9 -0.58 3.55e-31 Exhaled nitric oxide output; LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg23602909 chr7:157956050 PTPRN2 -0.5 -9.68 -0.47 1.06e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9906944 0.707 rs11655950 chr17:47129121 C/T cg14634687 chr17:47094252 IGF2BP1 0.32 6.75 0.35 6.54e-11 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg26769984 chr7:1090371 C7orf50 0.58 8.12 0.41 9.22e-15 Bronchopulmonary dysplasia; LUSC cis rs17102884 0.506 rs4899541 chr14:75403437 T/G cg06637938 chr14:75390232 RPS6KL1 -0.44 -6.55 -0.34 2.2e-10 Neuroticism; LUSC cis rs3931020 0.688 rs1051122 chr1:75190452 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.63 8.43 0.42 1.02e-15 Resistin levels; LUSC cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg15423357 chr2:25149977 NA 0.44 8.97 0.44 2.2e-17 Body mass index; LUSC trans rs17683430 0.702 rs117079807 chr22:32407021 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2835872 0.758 rs1787395 chr21:39036478 A/C cg20424643 chr21:39039972 KCNJ6 -0.45 -7.57 -0.38 3.65e-13 Electroencephalographic traits in alcoholism; LUSC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg22903471 chr2:27725779 GCKR -0.42 -7.13 -0.36 6.42e-12 Total body bone mineral density; LUSC cis rs10791097 0.642 rs7107568 chr11:130779668 T/C cg12179176 chr11:130786555 SNX19 0.9 17.34 0.69 1.8e-48 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs12579753 0.879 rs11115008 chr12:82164859 C/T cg07988820 chr12:82153109 PPFIA2 -0.44 -6.46 -0.33 3.67e-10 Resting heart rate; LUSC cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01632311 chr7:2281785 NUDT1;FTSJ2 -0.44 -6.83 -0.35 4.05e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.21 -0.37 3.86e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs61931739 0.500 rs11053243 chr12:34514155 T/C cg06521331 chr12:34319734 NA -0.41 -6.8 -0.35 4.96e-11 Morning vs. evening chronotype; LUSC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg14440974 chr22:39074834 NA -0.35 -5.84 -0.3 1.26e-8 Menopause (age at onset); LUSC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg13395646 chr4:1353034 KIAA1530 -0.78 -13.18 -0.59 3.08e-32 Obesity-related traits; LUSC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg20476274 chr7:133979776 SLC35B4 0.8 14.19 0.61 4.15e-36 Mean platelet volume; LUSC cis rs7683537 0.501 rs2171838 chr4:185667404 A/G cg04058563 chr4:185651563 MLF1IP -0.69 -9.63 -0.47 1.52e-19 Systemic lupus erythematosus; LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg05025164 chr4:1340916 KIAA1530 -0.65 -10.15 -0.49 2.87e-21 Obesity-related traits; LUSC cis rs950169 0.922 rs62021167 chr15:85118051 T/A cg11189052 chr15:85197271 WDR73 0.47 5.76 0.3 1.88e-8 Schizophrenia; LUSC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg18252515 chr7:66147081 NA -1.22 -13.35 -0.59 7.04e-33 Diabetic kidney disease; LUSC cis rs67696533 1.000 rs6141319 chr20:31144807 A/G cg13636640 chr20:31349939 DNMT3B 0.46 6.7 0.34 8.67e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs12928939 0.517 rs10852507 chr16:71971900 G/A cg03805757 chr16:71968109 PKD1L3 -0.64 -9.8 -0.47 4.31e-20 Post bronchodilator FEV1; LUSC cis rs77633900 0.614 rs280030 chr15:77026853 T/C cg21673338 chr15:77095150 SCAPER -0.81 -7.96 -0.4 2.63e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs7072216 0.763 rs2274243 chr10:100175267 T/C cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs5753037 0.809 rs5763512 chr22:30212366 C/T cg11564601 chr22:30592435 NA 0.32 5.72 0.3 2.39e-8 Type 1 diabetes; LUSC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg12927641 chr6:109611667 NA 0.44 7.67 0.39 1.95e-13 Reticulocyte fraction of red cells; LUSC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg11657440 chr19:46296263 DMWD -0.68 -10.2 -0.49 1.96e-21 Coronary artery disease; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg25703541 chr22:24373054 LOC391322 -0.98 -18.05 -0.7 2.69e-51 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg24812749 chr6:127587940 RNF146 0.86 12.58 0.57 5.68e-30 Breast cancer; LUSC trans rs1459104 0.759 rs7939392 chr11:55257285 C/T cg15704280 chr7:45808275 SEPT13 0.61 6.55 0.34 2.23e-10 Body mass index; LUSC cis rs55882075 0.634 rs11249657 chr5:179111637 G/C cg14593053 chr5:179126677 CANX 0.39 6.06 0.31 3.69e-9 Monocyte percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02003818 chr14:58893672 KIAA0586;TIMM9 -0.41 -6.32 -0.33 8.27e-10 Electrocardiographic conduction measures; LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg05368731 chr17:41323189 NBR1 0.94 16.46 0.67 5.38e-45 Menopause (age at onset); LUSC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg14983838 chr19:29218262 NA 0.65 9.87 0.48 2.53e-20 Methadone dose in opioid dependence; LUSC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg11062466 chr8:58055876 NA 0.7 8.01 0.4 1.91e-14 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.565 rs55857142 chr16:68236741 A/T cg09835421 chr16:68378352 PRMT7 -0.59 -6.32 -0.33 8.14e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9372253 1.000 rs7740028 chr6:110719180 A/G cg19196401 chr6:110721138 DDO -0.45 -8.49 -0.42 7.05e-16 Platelet distribution width; LUSC cis rs17270561 0.723 rs12213243 chr6:25890108 C/T cg16482183 chr6:26056742 HIST1H1C 0.88 11.7 0.54 9.71e-27 Iron status biomarkers; LUSC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.08 0.32 3.26e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2932538 0.922 rs6691917 chr1:113137043 G/C cg22162597 chr1:113214053 CAPZA1 0.53 7.69 0.39 1.66e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs988712 0.705 rs16917204 chr11:27668355 G/C cg10635145 chr11:27742435 BDNF -0.46 -5.96 -0.31 6.27e-9 Obesity; LUSC cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg03146154 chr1:46216737 IPP 0.52 7.74 0.39 1.22e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs834603 0.546 rs1704969 chr7:47467787 A/G cg09696706 chr7:47479511 TNS3 0.32 5.75 0.3 2.01e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11890956 chr21:40555474 PSMG1 -0.74 -11.4 -0.53 1.16e-25 Menarche (age at onset); LUSC cis rs2857891 0.817 rs1907611 chr11:6968302 A/G cg04053776 chr11:6947353 ZNF215 0.41 5.98 0.31 5.69e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs11971779 0.680 rs7785903 chr7:139122643 T/C cg23387468 chr7:139079360 LUC7L2 0.38 5.73 0.3 2.19e-8 Diisocyanate-induced asthma; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg23978390 chr7:1156363 C7orf50 0.5 7.17 0.37 4.98e-12 Longevity;Endometriosis; LUSC cis rs757278 0.552 rs35292549 chr7:117318803 G/A cg10524701 chr7:117356490 CTTNBP2 0.4 5.68 0.3 2.98e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs3087591 0.708 rs7503922 chr17:29641935 C/A cg24425628 chr17:29625626 OMG;NF1 0.48 7.23 0.37 3.31e-12 Hip circumference; LUSC cis rs4889855 0.530 rs75398920 chr17:78544540 C/T cg16591659 chr17:78472290 NA 0.33 5.86 0.31 1.1e-8 Fractional excretion of uric acid; LUSC cis rs367615 0.704 rs4286723 chr5:108835959 G/A cg17395555 chr5:108820864 NA 0.62 11.38 0.53 1.43e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg04369109 chr6:150039330 LATS1 -0.58 -8.47 -0.42 8.09e-16 Lung cancer; LUSC cis rs4409675 0.576 rs11247705 chr1:28212272 G/A cg23691781 chr1:28212827 C1orf38 0.32 7.43 0.38 9.44e-13 Corneal astigmatism; LUSC cis rs559928 0.948 rs1198984 chr11:64148420 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.57 -6.21 -0.32 1.61e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg27170947 chr2:26402098 FAM59B -0.7 -10.49 -0.5 1.87e-22 Gut microbiome composition (summer); LUSC cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg02527881 chr3:46936655 PTH1R -0.38 -6.67 -0.34 1.03e-10 Colorectal cancer; LUSC cis rs597583 0.664 rs10892133 chr11:117383694 C/T cg27161313 chr11:117392002 DSCAML1 -0.48 -7.6 -0.38 3.06e-13 Putamen volume; LUSC trans rs61931739 0.857 rs1828514 chr12:34139600 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.93 0.35 2.21e-11 Morning vs. evening chronotype; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg04015486 chr20:44044769 PIGT 0.44 6.4 0.33 5.25e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg04234412 chr22:24373322 LOC391322 -0.96 -18.07 -0.7 2.23e-51 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg24399712 chr22:39784796 NA -0.63 -10.75 -0.51 2.44e-23 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.789 rs12498994 chr4:120250818 A/C cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg12826209 chr6:26865740 GUSBL1 0.76 6.5 0.33 2.98e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg04455712 chr21:45112962 RRP1B 0.45 8.53 0.42 5.06e-16 Mean corpuscular volume; LUSC cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg21573476 chr21:45109991 RRP1B -0.4 -6.63 -0.34 1.33e-10 Mean corpuscular volume; LUSC cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg07061783 chr6:25882402 NA -0.37 -5.81 -0.3 1.42e-8 Blood metabolite levels; LUSC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs1018836 0.828 rs10086462 chr8:91558089 A/G cg16814680 chr8:91681699 NA -0.69 -11.18 -0.52 7.13e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 1.000 rs422424 chr20:25445446 G/C cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1712517 0.525 rs7911488 chr10:105154089 A/G cg04362960 chr10:104952993 NT5C2 -0.52 -6.97 -0.36 1.67e-11 Migraine; LUSC cis rs12618769 1.000 rs72825710 chr2:99239497 G/A cg10123293 chr2:99228465 UNC50 0.41 5.7 0.3 2.57e-8 Bipolar disorder; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg13094219 chr2:46926190 SOCS5 -0.4 -5.95 -0.31 6.68e-9 Triglycerides; LUSC cis rs56804039 1.000 rs34154295 chr8:8383477 C/T cg15556689 chr8:8085844 FLJ10661 -0.59 -7.41 -0.38 1.03e-12 Cervical cancer; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg04775059 chr7:64541387 NA 0.55 8.07 0.4 1.29e-14 Calcium levels; LUSC cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg24130564 chr14:104152367 KLC1 -0.42 -6.08 -0.32 3.38e-9 Body mass index; LUSC cis rs8028313 0.731 rs13380201 chr15:67973665 A/G cg24579218 chr15:68104479 NA -0.38 -6.55 -0.34 2.21e-10 Obesity; LUSC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg06558623 chr16:89946397 TCF25 1.1 9.65 0.47 1.34e-19 Skin colour saturation; LUSC cis rs860295 0.812 rs2297775 chr1:155735012 C/T cg08949192 chr1:155289623 RUSC1;FDPS 0.34 5.68 0.3 2.97e-8 Body mass index; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg11645453 chr3:52864694 ITIH4 -0.32 -7.48 -0.38 6.74e-13 Bipolar disorder; LUSC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg24209194 chr3:40518798 ZNF619 0.49 6.52 0.34 2.64e-10 Renal cell carcinoma; LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -8.28 -0.41 3.06e-15 Bipolar disorder and schizophrenia; LUSC trans rs1908814 0.516 rs11996277 chr8:11800031 G/A cg08975724 chr8:8085496 FLJ10661 0.46 6.65 0.34 1.22e-10 Neuroticism; LUSC cis rs11608355 0.618 rs7958220 chr12:109830980 T/C cg19025524 chr12:109796872 NA -0.47 -8.95 -0.44 2.6e-17 Neuroticism; LUSC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg18876405 chr7:65276391 NA -0.54 -8.64 -0.43 2.4e-16 Aortic root size; LUSC cis rs238295 0.766 rs6038204 chr20:5549071 T/A cg15842884 chr20:5591925 RP5-1022P6.2 -0.43 -5.87 -0.31 1.07e-8 Occipital cortical area (total cortical area interaction); LUSC cis rs2979489 0.786 rs62508366 chr8:30369499 G/A cg26383811 chr8:30366931 RBPMS -0.51 -7.89 -0.4 4.45e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs2637266 0.783 rs12268496 chr10:78487192 G/A cg18941641 chr10:78392320 NA 0.36 6.58 0.34 1.79e-10 Pulmonary function; LUSC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 9.93 0.48 1.55e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1044826 0.619 rs7375091 chr3:139090389 T/A cg00490450 chr3:139108681 COPB2 -0.5 -7.88 -0.4 4.66e-14 Obesity-related traits; LUSC cis rs12208915 0.731 rs9443630 chr6:79661777 G/T cg05283184 chr6:79620031 NA 0.48 7.25 0.37 2.86e-12 Left atrial antero-posterior diameter; LUSC cis rs7769051 1.000 rs9493454 chr6:133144629 G/T cg07930552 chr6:133119739 C6orf192 -0.79 -10.53 -0.5 1.41e-22 Type 2 diabetes nephropathy; LUSC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg05872129 chr22:39784769 NA -0.61 -11.33 -0.53 2.14e-25 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg18132916 chr6:79620363 NA -0.4 -6.14 -0.32 2.4e-9 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.0 -0.55 7.87e-28 Platelet count; LUSC cis rs877282 1.000 rs877281 chr10:771557 T/G cg17470449 chr10:769945 NA 0.54 7.38 0.37 1.24e-12 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09509035 chr1:235490977 GGPS1;ARID4B -0.44 -6.49 -0.33 3.1e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.72 13.25 0.59 1.73e-32 Intelligence (multi-trait analysis); LUSC cis rs12478296 1.000 rs4973685 chr2:243019089 A/C cg06360820 chr2:242988706 NA -0.91 -10.03 -0.48 7.34e-21 Obesity-related traits; LUSC cis rs2279817 0.863 rs12139706 chr1:18026435 G/A cg21791023 chr1:18019539 ARHGEF10L 0.47 6.86 0.35 3.35e-11 Neuroticism; LUSC cis rs10876993 0.928 rs2640636 chr12:58077544 A/G cg18357645 chr12:58087776 OS9 0.58 8.67 0.43 1.94e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg15448220 chr1:150897856 SETDB1 0.42 6.05 0.31 3.98e-9 Melanoma; LUSC cis rs8180040 1.000 rs807810 chr3:47403892 G/A cg02527881 chr3:46936655 PTH1R 0.42 7.53 0.38 4.79e-13 Colorectal cancer; LUSC cis rs7241530 0.662 rs12458336 chr18:75909080 T/A cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC trans rs7615952 0.932 rs7630077 chr3:125649676 T/C cg07211511 chr3:129823064 LOC729375 -1.27 -20.37 -0.74 1.62e-60 Blood pressure (smoking interaction); LUSC cis rs7917772 0.582 rs4408249 chr10:104374653 T/A cg05855489 chr10:104503620 C10orf26 -0.48 -7.3 -0.37 2.15e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9467711 0.606 rs12176317 chr6:26372786 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg20307385 chr11:47447363 PSMC3 -0.45 -5.78 -0.3 1.71e-8 Subjective well-being; LUSC cis rs7072216 0.690 rs113195335 chr10:100175532 A/C cg26618903 chr10:100175079 PYROXD2 -0.48 -8.96 -0.44 2.27e-17 Metabolite levels; LUSC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg24060327 chr5:131705240 SLC22A5 0.48 8.12 0.41 9.37e-15 Breast cancer; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg10351095 chr21:47802916 PCNT -0.42 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC cis rs1152591 0.524 rs1255991 chr14:64661642 G/A cg21174375 chr14:64681225 SYNE2 0.31 5.66 0.3 3.24e-8 Atrial fibrillation; LUSC cis rs500891 0.693 rs1145915 chr6:83989771 A/G cg08257003 chr6:84140564 ME1 0.33 7.15 0.36 5.67e-12 Platelet-derived growth factor BB levels; LUSC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg12292205 chr6:26970375 C6orf41 0.6 7.53 0.38 4.85e-13 Intelligence (multi-trait analysis); LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg01125463 chr6:42946178 PEX6 -0.36 -5.97 -0.31 6.19e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7589342 0.894 rs7557976 chr2:106435061 C/A cg14210321 chr2:106509881 NCK2 -0.54 -8.12 -0.41 9.28e-15 Addiction; LUSC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21582582 chr3:182698605 DCUN1D1 0.46 8.27 0.41 3.11e-15 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg20887711 chr4:1340912 KIAA1530 0.56 8.9 0.44 3.54e-17 Longevity; LUSC cis rs9325144 0.560 rs2387923 chr12:38662677 G/A cg26384229 chr12:38710491 ALG10B -0.67 -10.52 -0.5 1.46e-22 Morning vs. evening chronotype; LUSC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg02079420 chr8:82753780 SNX16 -0.38 -5.79 -0.3 1.64e-8 Diastolic blood pressure; LUSC cis rs4285028 0.948 rs34566912 chr3:121679626 G/A cg11130432 chr3:121712080 ILDR1 -0.64 -9.64 -0.47 1.48e-19 Multiple sclerosis; LUSC cis rs611744 0.647 rs676654 chr8:109242303 A/G cg18478394 chr8:109455254 TTC35 0.42 6.18 0.32 1.85e-9 Dupuytren's disease; LUSC cis rs5769765 0.542 rs1535189 chr22:50249131 T/C cg02269571 chr22:50332266 NA 0.58 7.48 0.38 6.75e-13 Schizophrenia; LUSC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg18479299 chr3:125709523 NA -0.51 -5.87 -0.31 1.05e-8 Blood pressure (smoking interaction); LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.47 -0.33 3.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg06238570 chr21:40685208 BRWD1 0.53 7.97 0.4 2.47e-14 Cognitive function; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg11494091 chr17:61959527 GH2 -0.64 -13.38 -0.59 5.62e-33 Prudent dietary pattern; LUSC cis rs782590 0.774 rs782632 chr2:55898290 C/G cg03859395 chr2:55845619 SMEK2 0.86 15.72 0.65 4.52e-42 Metabolic syndrome; LUSC cis rs56399783 0.901 rs73049327 chr7:2795544 T/G cg19731401 chr7:2775893 GNA12 0.72 8.62 0.43 2.68e-16 Childhood ear infection; LUSC cis rs12711979 0.692 rs6751947 chr2:3820739 G/A cg17052675 chr2:3827356 NA -0.58 -11.37 -0.53 1.47e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs7917772 0.582 rs12782153 chr10:104368294 A/G cg22532475 chr10:104410764 TRIM8 0.26 6.11 0.32 2.7e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 7.77 0.39 9.93e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7712401 0.623 rs922140 chr5:122088890 A/G cg19077854 chr5:122220652 SNX24 0.29 6.39 0.33 5.65e-10 Mean platelet volume; LUSC cis rs4803468 1.000 rs2241710 chr19:41912092 G/C cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.42 5.75 0.3 1.98e-8 Height; LUSC cis rs6723108 0.738 rs10928512 chr2:135451302 A/C cg12500956 chr2:135428796 TMEM163 0.27 6.38 0.33 5.97e-10 Type 2 diabetes; LUSC cis rs12950390 0.893 rs72831644 chr17:45824391 T/C cg06532163 chr17:45867833 NA 0.34 6.22 0.32 1.49e-9 IgG glycosylation; LUSC cis rs8078723 0.677 rs11658328 chr17:38149236 T/C cg17467752 chr17:38218738 THRA -0.7 -11.27 -0.52 3.54e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg07828340 chr4:882639 GAK 1.06 11.16 0.52 8.87e-25 Intelligence (multi-trait analysis); LUSC cis rs9393777 0.623 rs34313099 chr6:26489607 C/T cg05738196 chr6:26577821 NA -0.56 -6.16 -0.32 2.12e-9 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg24692254 chr21:30365293 RNF160 -0.79 -14.4 -0.62 6.32e-37 Dental caries; LUSC cis rs559928 1.000 rs559928 chr11:64150370 A/G cg24687543 chr11:63912206 MACROD1 -0.42 -6.15 -0.32 2.26e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7903847 0.642 rs11189178 chr10:99143272 T/G cg20016023 chr10:99160130 RRP12 -0.33 -8.07 -0.4 1.26e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg04944784 chr2:26401820 FAM59B -0.68 -9.49 -0.46 4.45e-19 Gut microbiome composition (summer); LUSC cis rs13385 0.769 rs34994530 chr5:139558669 C/T cg26211634 chr5:139558579 C5orf32 0.45 6.3 0.33 9.46e-10 Atrial fibrillation; LUSC cis rs17621444 0.522 rs10886579 chr10:121803607 C/T cg02041677 chr10:121771263 NA -0.34 -6.37 -0.33 6.24e-10 IgG glycosylation; LUSC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg05890377 chr2:74357713 NA 0.7 11.56 0.53 3.06e-26 Gestational age at birth (maternal effect); LUSC cis rs7572644 0.699 rs10194283 chr2:28159079 G/A cg27432699 chr2:27873401 GPN1 -0.51 -6.86 -0.35 3.39e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs654950 0.841 rs2759247 chr1:41991756 G/C cg06885757 chr1:42089581 HIVEP3 -0.37 -7.28 -0.37 2.38e-12 Airway imaging phenotypes; LUSC cis rs1801251 1.000 rs6714245 chr2:233580505 T/C cg08000102 chr2:233561755 GIGYF2 0.7 11.71 0.54 9.4e-27 Coronary artery disease; LUSC cis rs11577318 0.579 rs11247936 chr1:26698884 A/G cg00852783 chr1:26633632 UBXN11 -0.55 -7.49 -0.38 6.33e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.53 0.34 2.38e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg24838063 chr12:130822603 PIWIL1 0.71 11.02 0.52 2.71e-24 Menopause (age at onset); LUSC cis rs7833787 0.832 rs12546229 chr8:18701879 C/T cg17701159 chr8:18705777 PSD3 -0.37 -5.96 -0.31 6.34e-9 Obesity-related traits; LUSC trans rs561341 1.000 rs498391 chr17:30328704 G/A cg27661571 chr11:113659931 NA -0.69 -7.9 -0.4 4.08e-14 Hip circumference adjusted for BMI; LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg25036284 chr2:26402008 FAM59B 0.77 11.29 0.53 2.89e-25 Gut microbiome composition (summer); LUSC cis rs2760061 0.598 rs849904 chr1:228137145 G/C cg18477163 chr1:228402036 OBSCN -0.56 -10.27 -0.49 1.1e-21 Diastolic blood pressure; LUSC cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg21770322 chr7:97807741 LMTK2 0.47 7.93 0.4 3.39e-14 Breast cancer; LUSC trans rs62238980 0.614 rs743764 chr22:32459217 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs9549367 0.865 rs3861721 chr13:113906308 C/T cg00898013 chr13:113819073 PROZ -0.57 -8.13 -0.41 8.59e-15 Platelet distribution width; LUSC cis rs8025790 0.508 rs12905371 chr15:67845930 C/T cg27219399 chr15:67835830 MAP2K5 0.36 5.71 0.3 2.56e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs10760279 0.584 rs10760280 chr9:126112812 A/G cg14503395 chr9:126128745 CRB2 0.33 5.7 0.3 2.59e-8 Body mass index; LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg22963979 chr7:1858916 MAD1L1 -0.7 -11.64 -0.54 1.62e-26 Bipolar disorder and schizophrenia; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg18309895 chr10:105445329 SH3PXD2A -0.37 -6.07 -0.32 3.52e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6542838 0.641 rs7565510 chr2:99494833 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.33 -0.33 7.77e-10 Fear of minor pain; LUSC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs6696846 0.716 rs6593921 chr1:205062861 A/G cg21643547 chr1:205240462 TMCC2 -0.38 -6.95 -0.36 1.89e-11 Red blood cell count; LUSC cis rs701145 0.585 rs398512 chr3:153909988 T/C cg17054900 chr3:154042577 DHX36 0.68 6.76 0.35 5.99e-11 Coronary artery disease; LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.27 0.52 3.53e-25 Prudent dietary pattern; LUSC cis rs9372253 0.678 rs9372251 chr6:110700656 A/G cg00083206 chr6:110721305 DDO -0.43 -7.69 -0.39 1.66e-13 Platelet distribution width; LUSC cis rs11098499 0.863 rs3775843 chr4:120427844 T/C cg24375607 chr4:120327624 NA 0.76 11.36 0.53 1.73e-25 Corneal astigmatism; LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg19678392 chr7:94953810 PON1 -0.5 -9.61 -0.47 1.81e-19 Paraoxonase activity; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02047359 chr10:75174015 ANXA7 0.45 7.03 0.36 1.18e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs765787 0.530 rs28733848 chr15:45516047 C/T cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.44e-17 Uric acid levels; LUSC cis rs7095944 0.614 rs4962697 chr10:126447545 G/C cg08799069 chr10:126477246 METTL10 -0.41 -6.3 -0.33 9.46e-10 Asthma; LUSC cis rs1712517 0.873 rs7903004 chr10:105004101 G/A cg05636881 chr10:105038444 INA -0.39 -6.44 -0.33 4.18e-10 Migraine; LUSC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg13206674 chr6:150067644 NUP43 0.58 9.08 0.45 9.37e-18 Lung cancer; LUSC cis rs12891047 0.901 rs2235967 chr14:68249499 C/T cg20999565 chr14:68265668 ZFYVE26 0.39 5.89 0.31 9.42e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg07092213 chr7:1199455 ZFAND2A -0.64 -10.82 -0.51 1.34e-23 Longevity;Endometriosis; LUSC trans rs7819412 0.505 rs17782554 chr8:11022106 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.47 -0.38 7.19e-13 Triglycerides; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.6 7.62 0.38 2.59e-13 Renal function-related traits (BUN); LUSC cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg22709100 chr7:91322751 NA 0.41 6.0 0.31 5.02e-9 Breast cancer; LUSC cis rs72781680 0.752 rs55859418 chr2:23904231 C/A cg20701182 chr2:24300061 SF3B14 0.73 7.06 0.36 9.63e-12 Lymphocyte counts; LUSC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -6.89 -0.35 2.79e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs4664304 0.629 rs1606117 chr2:160850716 C/T cg05371993 chr16:1458494 UNKL 0.41 6.01 0.31 4.74e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6547741 0.967 rs4665999 chr2:27834444 T/C cg27432699 chr2:27873401 GPN1 0.8 14.94 0.63 5.09e-39 Oral cavity cancer; LUSC cis rs62103177 0.525 rs4799117 chr18:77756604 G/A cg20368463 chr18:77673604 PQLC1 -0.68 -7.43 -0.38 9.24e-13 Opioid sensitivity; LUSC cis rs4662945 0.525 rs4662951 chr2:130256272 C/T cg05962382 chr2:130345044 NA -0.36 -6.28 -0.32 1.05e-9 Response to cytidine analogues (gemcitabine); LUSC cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg13010199 chr12:38710504 ALG10B 0.62 9.23 0.45 3.2e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg00024416 chr22:24240387 NA 0.35 6.04 0.31 4.19e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.1 0.41 1.04e-14 Bipolar disorder; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg18876405 chr7:65276391 NA 0.49 7.66 0.39 1.98e-13 Calcium levels; LUSC cis rs2732480 0.577 rs2634691 chr12:48708259 G/T cg04545296 chr12:48745243 ZNF641 0.37 6.78 0.35 5.33e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1160297 0.585 rs12713229 chr2:53090105 T/C cg07782112 chr2:53107842 NA 0.37 6.22 0.32 1.46e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs6120849 0.663 rs6088662 chr20:33547633 A/C cg24642439 chr20:33292090 TP53INP2 0.59 6.79 0.35 5.13e-11 Protein C levels; LUSC cis rs8060686 0.641 rs112099181 chr16:68154230 T/C cg27539214 chr16:67997921 SLC12A4 -0.54 -7.27 -0.37 2.56e-12 HDL cholesterol;Metabolic syndrome; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg14591386 chr6:97345725 NDUFAF4 0.52 6.07 0.32 3.38e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1577917 1.000 rs34581302 chr6:86705948 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.73 -0.43 1.28e-16 Response to antipsychotic treatment; LUSC cis rs11190604 1.000 rs7090431 chr10:102261753 A/G cg07080220 chr10:102295463 HIF1AN 0.67 9.27 0.45 2.29e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11971779 0.648 rs6947309 chr7:139035830 C/T cg07862535 chr7:139043722 LUC7L2 0.52 6.58 0.34 1.81e-10 Diisocyanate-induced asthma; LUSC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg13902645 chr11:5959945 NA -0.58 -8.23 -0.41 4.32e-15 DNA methylation (variation); LUSC cis rs7584330 0.554 rs13405619 chr2:238445661 C/T cg14458575 chr2:238380390 NA 0.45 5.72 0.3 2.41e-8 Prostate cancer; LUSC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg11812906 chr14:75593930 NEK9 0.65 11.1 0.52 1.41e-24 Height; LUSC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg20608306 chr11:116969690 SIK3 0.38 6.39 0.33 5.59e-10 Blood protein levels; LUSC cis rs1595825 0.891 rs892513 chr2:198905874 A/G cg00982548 chr2:198649783 BOLL 0.53 6.69 0.34 9.31e-11 Ulcerative colitis; LUSC cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg08477640 chr19:41863820 B9D2 -0.5 -7.81 -0.39 7.6e-14 Migraine;Coronary artery disease; LUSC cis rs9311676 0.632 rs67904096 chr3:58365508 T/A cg13750441 chr3:58318267 PXK 0.35 6.76 0.35 6.33e-11 Systemic lupus erythematosus; LUSC cis rs4969178 0.896 rs12602206 chr17:76397133 A/G cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs6964587 1.000 rs4727267 chr7:91570290 G/C cg01689657 chr7:91764605 CYP51A1 -0.33 -6.06 -0.31 3.68e-9 Breast cancer; LUSC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg04944784 chr2:26401820 FAM59B 0.65 8.32 0.41 2.22e-15 Gut microbiome composition (summer); LUSC cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg13010199 chr12:38710504 ALG10B 0.66 10.21 0.49 1.83e-21 Bladder cancer; LUSC cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs10484885 0.591 rs72912551 chr6:90178347 C/T cg13799429 chr6:90582589 CASP8AP2 -0.64 -5.95 -0.31 6.77e-9 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.96 -0.36 1.83e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg24324837 chr19:49891574 CCDC155 0.53 7.39 0.37 1.17e-12 Multiple sclerosis; LUSC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg12564285 chr5:131593104 PDLIM4 0.42 7.7 0.39 1.52e-13 Breast cancer; LUSC cis rs9902453 0.845 rs2321331 chr17:28025528 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.44 0.46 6.85e-19 Coffee consumption (cups per day); LUSC cis rs7188861 0.768 rs12925649 chr16:11390445 T/C cg00044050 chr16:11439710 C16orf75 0.53 5.99 0.31 5.45e-9 HDL cholesterol; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg22907277 chr7:1156413 C7orf50 0.6 9.37 0.46 1.16e-18 Longevity;Endometriosis; LUSC cis rs62458065 0.850 rs73096034 chr7:32472048 A/G cg20159608 chr7:32802032 NA -0.66 -7.83 -0.39 6.35e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7923609 0.967 rs4486511 chr10:65264266 C/T cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.07e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.87 -0.48 2.59e-20 Glomerular filtration rate (creatinine); LUSC cis rs11105298 0.891 rs11105316 chr12:89925200 T/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.06e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7666738 0.515 rs11733968 chr4:98906448 A/C cg17366294 chr4:99064904 C4orf37 -0.52 -8.77 -0.43 9.01e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs4975709 0.838 rs4975752 chr5:1880588 A/C cg15595755 chr5:1867978 NA 0.4 6.43 0.33 4.34e-10 Cardiovascular disease risk factors; LUSC cis rs9902453 0.791 rs28492945 chr17:28223982 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.38 0.53 1.44e-25 Coffee consumption (cups per day); LUSC cis rs6740322 0.841 rs10210507 chr2:43556636 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.56 -7.7 -0.39 1.6e-13 Coronary artery disease; LUSC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg03351412 chr1:154909251 PMVK 0.52 8.08 0.4 1.18e-14 Prostate cancer; LUSC cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.99 0.55 8.55e-28 Chronic sinus infection; LUSC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg12751644 chr20:60527061 NA -0.33 -6.14 -0.32 2.4e-9 Body mass index; LUSC cis rs74181299 0.964 rs2540951 chr2:65276736 A/G cg05010058 chr2:65284262 CEP68 0.31 6.17 0.32 1.97e-9 Pulse pressure; LUSC cis rs12195417 0.574 rs1170459 chr6:84000234 G/T cg08257003 chr6:84140564 ME1 0.32 7.58 0.38 3.4e-13 Schizophrenia; LUSC cis rs11264213 0.901 rs72661613 chr1:36364781 A/G cg27506609 chr1:36549197 TEKT2 0.7 8.04 0.4 1.62e-14 Schizophrenia; LUSC cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg03684893 chr10:554711 DIP2C -0.38 -6.93 -0.35 2.24e-11 Psychosis in Alzheimer's disease; LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.09 0.77 2.83e-67 Prudent dietary pattern; LUSC cis rs9788721 0.934 rs55676755 chr15:78898932 C/G cg06917634 chr15:78832804 PSMA4 -0.44 -5.96 -0.31 6.28e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg13736514 chr6:26305472 NA -0.47 -9.37 -0.46 1.16e-18 Educational attainment; LUSC trans rs7939886 0.920 rs1905069 chr11:55887135 T/C cg15704280 chr7:45808275 SEPT13 0.82 6.77 0.35 5.73e-11 Myopia (pathological); LUSC cis rs2486288 0.656 rs12911861 chr15:45566718 T/C cg09092052 chr15:45571596 NA 0.47 6.64 0.34 1.24e-10 Glomerular filtration rate; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.6 10.15 0.49 2.75e-21 Lymphocyte counts; LUSC cis rs1577917 0.876 rs11752223 chr6:86573394 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.91 -0.35 2.52e-11 Response to antipsychotic treatment; LUSC cis rs244293 0.700 rs12939352 chr17:53007655 T/G cg19360675 chr17:53046073 COX11;STXBP4 -0.42 -6.25 -0.32 1.28e-9 Menarche (age at onset); LUSC cis rs1957429 0.808 rs1570296 chr14:65332294 T/A cg23373153 chr14:65346875 NA 0.95 10.83 0.51 1.25e-23 Pediatric areal bone mineral density (radius); LUSC cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.15e-14 Glomerular filtration rate (creatinine); LUSC cis rs9650315 0.866 rs76623919 chr8:57191191 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.54 6.96 0.36 1.75e-11 Height; LUSC cis rs6430585 0.527 rs1446586 chr2:136407445 C/T cg07169764 chr2:136633963 MCM6 -1.04 -14.03 -0.61 1.73e-35 Corneal structure; LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg20135002 chr11:47629003 NA -0.51 -8.1 -0.41 1.07e-14 Neuroticism; LUSC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg09323728 chr8:95962352 TP53INP1 -0.31 -5.83 -0.3 1.34e-8 Type 2 diabetes; LUSC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 8.08 0.4 1.18e-14 Lung cancer; LUSC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg18681998 chr4:17616180 MED28 0.85 15.67 0.65 6.85e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg10802521 chr3:52805072 NEK4 -0.55 -8.99 -0.44 1.85e-17 Electroencephalogram traits; LUSC cis rs7681440 0.904 rs2870029 chr4:90772057 G/T cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.22e-8 Dementia with Lewy bodies; LUSC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg27532560 chr4:187881888 NA -0.38 -6.27 -0.32 1.1e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs6980507 0.523 rs2974294 chr8:42369473 C/T cg09913449 chr8:42400586 C8orf40 -0.44 -7.71 -0.39 1.44e-13 Glycated hemoglobin levels; LUSC cis rs7681440 0.904 rs28777703 chr4:90769924 A/G cg01966878 chr4:90757139 SNCA 0.35 6.1 0.32 2.9e-9 Dementia with Lewy bodies; LUSC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg12463550 chr7:65579703 CRCP 0.45 6.76 0.35 6.2e-11 Aortic root size; LUSC cis rs9649213 0.559 rs56997921 chr7:98009224 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.72 -10.12 -0.48 3.48e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs9494145 0.838 rs9483788 chr6:135435501 T/C cg22676075 chr6:135203613 NA 0.57 7.43 0.38 9.09e-13 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs760805 0.932 rs1005734 chr1:25262022 C/A cg22509179 chr1:25234806 RUNX3 -0.61 -10.16 -0.49 2.58e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs8072100 0.967 rs4338849 chr17:45512483 A/G cg08085267 chr17:45401833 C17orf57 -0.63 -10.73 -0.51 2.9e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg07157834 chr1:205819609 PM20D1 -0.73 -13.75 -0.6 2.2e-34 Monocyte percentage of white cells; LUSC cis rs6546537 1.000 rs2048256 chr2:69847357 G/C cg10773587 chr2:69614142 GFPT1 -0.54 -8.13 -0.41 8.56e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs9902453 0.967 rs6505155 chr17:28372783 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.89 -0.44 3.97e-17 Coffee consumption (cups per day); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09613494 chr21:44846625 SIK1 0.43 5.98 0.31 5.64e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg01973587 chr1:228161476 NA -0.46 -8.31 -0.41 2.43e-15 Diastolic blood pressure; LUSC cis rs2658782 0.724 rs2248655 chr11:93254612 T/C cg15737290 chr11:93063684 CCDC67 0.61 7.33 0.37 1.79e-12 Pulmonary function decline; LUSC cis rs10740039 0.842 rs7069157 chr10:62389233 A/G cg18175470 chr10:62150864 ANK3 -0.48 -7.11 -0.36 7.18e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10238396 chr2:64067940 UGP2 -0.4 -6.17 -0.32 2e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4499344 0.622 rs73573371 chr19:33047095 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.79 -10.04 -0.48 6.86e-21 Mean platelet volume; LUSC cis rs9393777 0.557 rs6933999 chr6:27074929 G/A cg12826209 chr6:26865740 GUSBL1 0.63 8.43 0.42 1.03e-15 Intelligence (multi-trait analysis); LUSC cis rs6828523 0.698 rs4695984 chr4:175858796 C/T cg16870595 chr4:175839423 ADAM29 0.49 6.09 0.32 3.04e-9 Breast cancer; LUSC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.08 0.32 3.27e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs61990749 0.597 rs12896026 chr14:78244436 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.61 6.69 0.34 9.25e-11 Fibroblast growth factor basic levels; LUSC cis rs7200543 1.000 rs72774845 chr16:15147954 A/C cg03427771 chr16:15082598 PDXDC1 -0.4 -5.81 -0.3 1.47e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10120925 chr2:223520811 FARSB -0.41 -6.06 -0.31 3.66e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7617480 0.616 rs9873227 chr3:48773108 G/C cg07636037 chr3:49044803 WDR6 0.87 11.31 0.53 2.55e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.07 -0.36 9.2e-12 Alzheimer's disease (late onset); LUSC cis rs2816062 0.721 rs2816047 chr1:18893728 A/C cg18795169 chr1:18902165 NA -1.0 -23.93 -0.79 2.05e-74 Urate levels in lean individuals; LUSC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg20243544 chr17:37824526 PNMT -0.48 -5.84 -0.3 1.22e-8 Glomerular filtration rate (creatinine); LUSC cis rs10203711 0.966 rs6716938 chr2:239599283 A/G cg14580085 chr2:239553406 NA 0.43 7.2 0.37 4.12e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2730245 0.527 rs2527194 chr7:158732959 G/A cg11984989 chr7:158649758 WDR60 -1.04 -12.33 -0.56 4.97e-29 Height; LUSC cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg01943577 chr7:158741284 NA -0.4 -5.74 -0.3 2.15e-8 Height; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg05863683 chr7:1912471 MAD1L1 0.3 5.65 0.3 3.39e-8 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.01 -0.4 1.98e-14 Lung cancer; LUSC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.62e-13 Bipolar disorder; LUSC cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC trans rs2838344 0.776 rs2298561 chr21:45085234 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 9.89 0.48 2.13e-20 Coronary artery disease; LUSC cis rs8038465 0.967 rs55868793 chr15:73956856 T/G cg15420318 chr15:73925796 NPTN 0.42 6.84 0.35 3.82e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs34734847 1.000 rs34734847 chr12:121154221 T/C cg21892295 chr12:121157589 UNC119B -0.51 -9.35 -0.46 1.29e-18 Mean corpuscular volume; LUSC cis rs9788682 1.000 rs57064725 chr15:78833036 C/A cg06917634 chr15:78832804 PSMA4 -0.54 -6.79 -0.35 5.03e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs77956314 0.515 rs60940473 chr12:117462582 C/T cg02017074 chr12:117425053 FBXW8 -0.65 -7.66 -0.39 1.98e-13 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs897984 0.683 rs12447534 chr16:30804257 C/T cg02466173 chr16:30829666 NA 0.69 16.24 0.66 3.88e-44 Dementia with Lewy bodies; LUSC cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg23029597 chr12:123009494 RSRC2 -0.74 -9.58 -0.46 2.27e-19 Body mass index; LUSC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg17173187 chr15:85201210 NMB -0.33 -6.81 -0.35 4.42e-11 P wave terminal force; LUSC cis rs8114671 0.836 rs13042358 chr20:33634479 G/A cg24642439 chr20:33292090 TP53INP2 -0.4 -5.76 -0.3 1.92e-8 Height; LUSC cis rs4285028 0.948 rs12488334 chr3:121702526 T/C cg11130432 chr3:121712080 ILDR1 -0.65 -9.82 -0.47 3.69e-20 Multiple sclerosis; LUSC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg17366294 chr4:99064904 C4orf37 0.56 9.91 0.48 1.76e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.871 rs55953412 chr11:68328283 C/T cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.54e-9 Total body bone mineral density; LUSC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.75 0.35 6.4e-11 Menarche (age at onset); LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg08888203 chr3:10149979 C3orf24 0.61 8.44 0.42 9.76e-16 Alzheimer's disease; LUSC cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 5.86 0.31 1.09e-8 Rheumatoid arthritis; LUSC cis rs10746514 1.000 rs10864715 chr1:232243817 G/A cg09506761 chr1:232265262 NA 0.54 8.72 0.43 1.34e-16 Response to statin therapy; LUSC cis rs1775715 0.737 rs2778672 chr10:32122419 T/C cg18675610 chr10:32216311 ARHGAP12 0.29 6.23 0.32 1.44e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7772486 0.902 rs2144476 chr6:146322484 G/A cg05347473 chr6:146136440 FBXO30 0.43 7.05 0.36 1.02e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7940866 0.774 rs10894292 chr11:130820757 C/T cg12179176 chr11:130786555 SNX19 0.64 9.73 0.47 7.5e-20 Schizophrenia; LUSC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg14668632 chr7:2872130 GNA12 -0.46 -7.14 -0.36 5.8e-12 Height; LUSC trans rs11098499 1.000 rs10029750 chr4:120172543 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.39 0.33 5.53e-10 Corneal astigmatism; LUSC cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg03060546 chr3:49711283 APEH 0.65 7.28 0.37 2.42e-12 Menarche (age at onset); LUSC trans rs10432489 0.708 rs3922471 chr2:181771937 T/C cg07312954 chr1:153914453 DENND4B -0.83 -6.07 -0.32 3.54e-9 QT interval; LUSC cis rs2742234 0.541 rs10793426 chr10:43745280 G/A cg15436174 chr10:43711423 RASGEF1A 0.42 6.71 0.34 8.14e-11 Hirschsprung disease; LUSC cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg03146154 chr1:46216737 IPP 0.55 8.21 0.41 5.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg07167872 chr1:205819463 PM20D1 0.54 9.1 0.45 8.19e-18 Menarche (age at onset); LUSC cis rs4253772 0.530 rs11090875 chr22:46785301 C/T cg18190219 chr22:46762943 CELSR1 -0.58 -5.68 -0.3 2.93e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg09177884 chr7:1199841 ZFAND2A -0.58 -8.22 -0.41 4.41e-15 Longevity;Endometriosis; LUSC trans rs4729127 0.901 rs112784431 chr7:94017313 G/A cg20086523 chr13:52378287 DHRS12 0.62 6.69 0.34 9.44e-11 Intelligence; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06812693 chr4:26323246 RBPJ 0.48 7.19 0.37 4.21e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg26314531 chr2:26401878 FAM59B -0.69 -9.39 -0.46 9.76e-19 Gut microbiome composition (summer); LUSC trans rs79976124 0.879 rs17511467 chr6:66627293 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 8.49 0.42 7.03e-16 Type 2 diabetes; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg11710924 chr2:32503219 YIPF4 0.37 6.21 0.32 1.55e-9 Asthma; LUSC cis rs12824058 0.737 rs2398510 chr12:130816637 G/A cg26677194 chr12:130822605 PIWIL1 0.6 8.79 0.43 7.95e-17 Menopause (age at onset); LUSC cis rs3916 0.688 rs9204 chr12:121177778 A/G cg27246729 chr12:121163418 ACADS 0.43 6.41 0.33 4.85e-10 Urinary metabolites (H-NMR features); LUSC cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.78 -0.35 5.62e-11 Monocyte percentage of white cells; LUSC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg15556689 chr8:8085844 FLJ10661 -0.7 -11.53 -0.53 4.08e-26 Mood instability; LUSC trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg13615516 chr5:77269221 NA 0.39 6.62 0.34 1.4e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg12011299 chr4:100065546 ADH4 -0.72 -11.25 -0.52 4.13e-25 Alcohol dependence; LUSC cis rs2204008 0.582 rs11179135 chr12:38204689 A/C cg13010199 chr12:38710504 ALG10B 0.7 10.59 0.5 8.81e-23 Bladder cancer; LUSC cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg24692254 chr21:30365293 RNF160 0.91 18.66 0.71 9.36e-54 Dental caries; LUSC cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.33 0.49 6.73e-22 Schizophrenia; LUSC cis rs11971779 0.564 rs6467841 chr7:139066092 T/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs4664304 0.802 rs62175470 chr2:160858255 G/C cg03641300 chr2:160917029 PLA2R1 -0.38 -6.1 -0.32 2.98e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs317689 0.718 rs315122 chr12:69771073 G/T cg20891283 chr12:69753455 YEATS4 0.59 8.08 0.4 1.22e-14 Response to diuretic therapy; LUSC cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg05283184 chr6:79620031 NA -0.58 -12.17 -0.55 1.82e-28 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.764 rs11683121 chr2:100920705 C/T cg12002119 chr2:101014098 CHST10 0.34 5.74 0.3 2.1e-8 Intelligence (multi-trait analysis); LUSC cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.46 -0.42 8.29e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg19052272 chr2:3704530 ALLC -0.46 -7.58 -0.38 3.35e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs524023 0.958 rs2021860 chr11:64361384 G/T cg07220939 chr11:64358617 SLC22A12 -0.22 -5.76 -0.3 1.91e-8 Urate levels in obese individuals; LUSC trans rs453301 0.571 rs2929452 chr8:9084465 G/A cg21775007 chr8:11205619 TDH -0.44 -6.18 -0.32 1.84e-9 Joint mobility (Beighton score); LUSC cis rs13256369 0.802 rs11995449 chr8:8559898 G/A cg18904891 chr8:8559673 CLDN23 0.6 7.82 0.39 7.06e-14 Obesity-related traits; LUSC cis rs17688076 0.511 rs2418738 chr16:68122604 G/C cg04539111 chr16:67997858 SLC12A4 -0.42 -5.87 -0.31 1.04e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); LUSC cis rs5758511 0.680 rs5758657 chr22:42618669 A/G cg00645731 chr22:42541494 CYP2D7P1 0.58 10.21 0.49 1.8e-21 Birth weight; LUSC cis rs636291 0.517 rs673254 chr1:10550352 C/T cg17425144 chr1:10567563 PEX14 0.61 12.82 0.57 6.89e-31 Prostate cancer; LUSC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg06636001 chr8:8085503 FLJ10661 -0.55 -9.07 -0.44 1.07e-17 Mood instability; LUSC cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.6 0.85 2.14e-95 Chronic sinus infection; LUSC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 7.66e-25 Mean corpuscular volume; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -1.0 -12.21 -0.56 1.28e-28 Alzheimer's disease; LUSC trans rs62238980 0.614 rs116872567 chr22:32460255 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs3799379 0.550 rs9467736 chr6:26380032 A/G cg09904177 chr6:26538194 HMGN4 -0.46 -6.26 -0.32 1.21e-9 Intelligence (multi-trait analysis); LUSC cis rs7940866 0.874 rs10894290 chr11:130811049 T/G cg12179176 chr11:130786555 SNX19 0.62 9.28 0.45 2.22e-18 Schizophrenia; LUSC cis rs568617 0.953 rs583887 chr11:65644027 T/C cg19792802 chr11:65647270 CTSW -0.41 -6.21 -0.32 1.54e-9 Crohn's disease; LUSC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg11812906 chr14:75593930 NEK9 -0.64 -10.47 -0.5 2.32e-22 Height; LUSC cis rs7220711 1.000 rs8072333 chr17:41793893 C/T cg26893861 chr17:41843967 DUSP3 0.43 6.04 0.31 4.22e-9 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs9311676 0.656 rs10866016 chr3:58390844 C/T cg26110898 chr3:58419937 PDHB 0.4 6.46 0.33 3.74e-10 Systemic lupus erythematosus; LUSC cis rs11098499 0.954 rs10017371 chr4:120293776 A/G cg09307838 chr4:120376055 NA 0.8 11.28 0.53 3.3e-25 Corneal astigmatism; LUSC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC trans rs2204008 0.837 rs7974888 chr12:37945215 A/G cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.26e-10 Bladder cancer; LUSC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg00166722 chr3:10149974 C3orf24 0.39 5.81 0.3 1.43e-8 Alzheimer's disease; LUSC cis rs6714710 0.580 rs6711101 chr2:98379813 G/A cg26665480 chr2:98280029 ACTR1B 0.58 8.38 0.42 1.51e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs4942242 0.512 rs9533552 chr13:44187194 C/T cg19169023 chr15:41853346 TYRO3 -0.66 -9.97 -0.48 1.18e-20 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9527 0.668 rs7092815 chr10:104736345 G/T cg05855489 chr10:104503620 C10orf26 0.51 7.56 0.38 3.95e-13 Arsenic metabolism; LUSC cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg23711669 chr6:146136114 FBXO30 0.84 14.36 0.62 9.59e-37 Lobe attachment (rater-scored or self-reported); LUSC trans rs6089829 0.962 rs3899032 chr20:61658542 G/A cg13615516 chr5:77269221 NA 0.4 6.56 0.34 2.02e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1355223 0.902 rs7121272 chr11:34752562 T/G cg11058730 chr11:34937778 PDHX;APIP -0.39 -5.65 -0.3 3.4e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.44 6.88 0.35 2.97e-11 Depressive symptoms; LUSC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg07701084 chr6:150067640 NUP43 0.55 8.35 0.42 1.78e-15 Lung cancer; LUSC trans rs2363709 0.881 rs73096338 chr3:67387800 C/T cg23062198 chr2:14774063 FAM84A 0.58 6.21 0.32 1.58e-9 IgE levels; LUSC cis rs7903847 0.620 rs10882904 chr10:99115683 A/G cg08345082 chr10:99160200 RRP12 -0.35 -6.94 -0.35 2.1e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg15468180 chr1:107600409 PRMT6 -0.39 -6.3 -0.33 9.37e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs870825 0.616 rs6818447 chr4:185650154 G/A cg04058563 chr4:185651563 MLF1IP 0.81 12.21 0.56 1.35e-28 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15703070 chr1:227128038 CABC1 -0.43 -6.43 -0.33 4.47e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs11039798 1.000 rs7125913 chr11:48984318 G/A cg03929089 chr4:120376271 NA 0.71 6.79 0.35 5.04e-11 Axial length; LUSC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg06713675 chr4:122721982 EXOSC9 -0.48 -8.41 -0.42 1.2e-15 Type 2 diabetes; LUSC cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.77 0.35 5.7e-11 Rheumatoid arthritis; LUSC cis rs2969070 0.898 rs2906165 chr7:2508177 T/C cg03277898 chr7:2518824 NA -0.27 -5.76 -0.3 1.87e-8 Diastolic blood pressure; LUSC cis rs2224391 0.518 rs116670419 chr6:5261263 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.46 -5.75 -0.3 2.02e-8 Height; LUSC trans rs853679 0.607 rs28360499 chr6:27945396 G/A cg06606381 chr12:133084897 FBRSL1 -0.95 -8.54 -0.42 4.88e-16 Depression; LUSC cis rs1878931 0.582 rs9635562 chr16:3416689 G/A cg00484396 chr16:3507460 NAT15 -0.46 -6.77 -0.35 5.73e-11 Body mass index (adult); LUSC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.47e-12 Lung disease severity in cystic fibrosis; LUSC cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -7.01 -0.36 1.33e-11 Chronic sinus infection; LUSC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12497850 0.644 rs11928552 chr3:48739883 T/C cg07636037 chr3:49044803 WDR6 0.9 14.5 0.62 2.81e-37 Parkinson's disease; LUSC cis rs8114671 0.836 rs1885114 chr20:33577361 A/G cg24642439 chr20:33292090 TP53INP2 -0.42 -6.12 -0.32 2.67e-9 Height; LUSC trans rs61931739 0.517 rs1586409 chr12:34046614 C/A cg13010199 chr12:38710504 ALG10B 0.53 7.95 0.4 2.82e-14 Morning vs. evening chronotype; LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg23205692 chr1:25664452 TMEM50A 0.45 6.75 0.35 6.4e-11 Erythrocyte sedimentation rate; LUSC cis rs11603020 0.950 rs11229066 chr11:57374871 C/G cg23127183 chr11:57508653 C11orf31 -0.45 -6.18 -0.32 1.82e-9 Blood protein levels; LUSC cis rs4466137 0.904 rs6887104 chr5:83003535 G/A cg16102102 chr5:83017553 HAPLN1 -0.94 -14.19 -0.61 4.29e-36 Prostate cancer; LUSC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg02896835 chr1:92012615 NA 0.64 11.4 0.53 1.22e-25 Breast cancer; LUSC cis rs9420 0.961 rs11570190 chr11:57560452 A/C cg02958346 chr11:57425731 CLP1 -0.44 -6.43 -0.33 4.54e-10 Schizophrenia; LUSC cis rs9581857 0.547 rs75800999 chr13:28055293 A/G cg22138327 chr13:27999177 GTF3A 0.77 8.18 0.41 5.84e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC trans rs9388451 0.839 rs10457469 chr6:126083658 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.61 -9.7 -0.47 9.43e-20 Brugada syndrome; LUSC cis rs9527 0.590 rs7087459 chr10:104790999 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.57 0.46 2.39e-19 Arsenic metabolism; LUSC cis rs10465746 0.747 rs34155960 chr1:84447539 T/G cg10977910 chr1:84465055 TTLL7 0.44 6.37 0.33 6.26e-10 Obesity-related traits; LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg13560548 chr3:10150139 C3orf24 0.54 7.42 0.38 9.97e-13 Alzheimer's disease; LUSC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg14196790 chr5:131705035 SLC22A5 0.49 8.32 0.41 2.31e-15 Blood metabolite levels; LUSC cis rs4666002 0.956 rs4665383 chr2:27791555 C/G cg27432699 chr2:27873401 GPN1 0.43 6.07 0.32 3.43e-9 Phospholipid levels (plasma); LUSC cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg08999081 chr20:33150536 PIGU 0.44 8.13 0.41 8.26e-15 Coronary artery disease; LUSC cis rs12145833 0.596 rs61833906 chr1:243419706 T/C cg02356786 chr1:243265016 LOC731275 0.68 6.23 0.32 1.41e-9 Obesity (early onset extreme); LUSC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.61 0.5 7.35e-23 Monocyte percentage of white cells; LUSC cis rs3768617 0.510 rs3768619 chr1:183092404 C/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.94 0.51 4.97e-24 Fuchs's corneal dystrophy; LUSC cis rs782590 0.967 rs1975484 chr2:55803167 T/A cg18811423 chr2:55921094 PNPT1 0.83 14.27 0.62 2.19e-36 Metabolic syndrome; LUSC cis rs208520 0.690 rs12192710 chr6:66718137 C/T cg07460842 chr6:66804631 NA 1.1 17.21 0.69 5.83e-48 Exhaled nitric oxide output; LUSC cis rs6961069 0.756 rs4731642 chr7:80248001 A/G cg04458919 chr7:80252533 CD36 0.35 5.97 0.31 6.21e-9 Platelet count; LUSC cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg24879335 chr3:133465180 TF 0.44 7.51 0.38 5.49e-13 Iron status biomarkers (transferrin levels); LUSC cis rs11098499 0.954 rs7654587 chr4:120388406 C/T cg24375607 chr4:120327624 NA 0.79 11.67 0.54 1.23e-26 Corneal astigmatism; LUSC cis rs929354 1.000 rs1182413 chr7:157058557 G/A cg05182265 chr7:156933206 UBE3C 0.45 6.85 0.35 3.58e-11 Body mass index; LUSC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg09796270 chr17:17721594 SREBF1 -0.42 -7.2 -0.37 3.89e-12 Body mass index; LUSC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg06544989 chr22:39130855 UNC84B 0.33 5.76 0.3 1.86e-8 Menopause (age at onset); LUSC cis rs4363385 0.720 rs6665527 chr1:152967009 C/A cg00922841 chr1:152955080 SPRR1A -0.42 -7.32 -0.37 1.85e-12 Inflammatory skin disease; LUSC cis rs9814567 0.806 rs4955526 chr3:134317337 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.86 -0.58 4.9e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22307029 chr19:49891270 CCDC155 0.68 9.57 0.46 2.55e-19 Multiple sclerosis; LUSC cis rs868036 0.681 rs3784718 chr15:68098004 C/T cg08079166 chr15:68083412 MAP2K5 0.41 7.43 0.38 8.94e-13 Restless legs syndrome; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.68 0.54 1.18e-26 Prudent dietary pattern; LUSC cis rs7582180 0.591 rs2241810 chr2:101011877 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.68 -0.43 1.83e-16 Intelligence (multi-trait analysis); LUSC cis rs10740039 0.810 rs2165691 chr10:62371649 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.84 -0.35 3.76e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.954 rs1546505 chr4:120241224 A/G cg24375607 chr4:120327624 NA 0.82 11.96 0.55 1.08e-27 Corneal astigmatism; LUSC cis rs9549260 0.755 rs2755214 chr13:41149345 T/G cg21288729 chr13:41239152 FOXO1 0.6 9.39 0.46 9.46e-19 Red blood cell count; LUSC cis rs10752881 0.652 rs10911262 chr1:183114956 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 10.08 0.48 4.84e-21 Colorectal cancer; LUSC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.3 0.49 8.56e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9943753 0.508 rs11066422 chr12:109807153 A/G cg19025524 chr12:109796872 NA -0.39 -7.12 -0.36 6.5e-12 HDL cholesterol; LUSC cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.99 -0.36 1.54e-11 Menarche (age at onset); LUSC trans rs11098499 0.754 rs11098502 chr4:120252063 T/A cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg22437258 chr11:111473054 SIK2 -0.49 -6.82 -0.35 4.3e-11 Primary sclerosing cholangitis; LUSC cis rs7584330 0.737 rs937392 chr2:238367130 C/T cg16989719 chr2:238392110 NA -0.38 -6.57 -0.34 1.92e-10 Prostate cancer; LUSC cis rs6700896 0.931 rs2211651 chr1:66156021 G/T cg04111102 chr1:66153794 NA 0.33 7.33 0.37 1.72e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Urate levels; LUSC cis rs7481584 0.624 rs413368 chr11:3047646 C/G cg25174290 chr11:3078921 CARS -0.41 -6.19 -0.32 1.8e-9 Calcium levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg25355645 chr19:42873746 MEGF8 -0.41 -6.21 -0.32 1.56e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs600231 0.690 rs1152619 chr11:65255589 C/A cg21890820 chr11:65308645 LTBP3 0.52 7.05 0.36 1.02e-11 Bone mineral density; LUSC cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg26384229 chr12:38710491 ALG10B 0.88 15.03 0.64 2.3e-39 Bladder cancer; LUSC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg24550644 chr17:30846204 MYO1D -0.56 -9.64 -0.47 1.46e-19 Schizophrenia; LUSC cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg25427524 chr10:38739819 LOC399744 -0.68 -11.87 -0.54 2.3e-27 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7769051 1.000 rs5006218 chr6:133126220 T/G cg07930552 chr6:133119739 C6orf192 0.79 10.25 0.49 1.34e-21 Type 2 diabetes nephropathy; LUSC cis rs281408 0.559 rs204248 chr19:49216224 G/C cg13540341 chr19:49222985 MAMSTR 0.38 6.24 0.32 1.31e-9 Urinary metabolites (H-NMR features); LUSC cis rs62400317 0.826 rs62438867 chr6:45049787 G/A cg20913747 chr6:44695427 NA -0.46 -7.45 -0.38 8.3e-13 Total body bone mineral density; LUSC cis rs427941 0.595 rs201477 chr7:101746915 G/A cg06246474 chr7:101738831 CUX1 0.39 6.42 0.33 4.68e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg22764044 chr5:178986830 RUFY1 -0.6 -10.93 -0.51 5.73e-24 Lung cancer; LUSC cis rs1003719 0.715 rs7280251 chr21:38567911 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.2 -0.49 1.9e-21 Eye color traits; LUSC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg20135002 chr11:47629003 NA -0.5 -7.86 -0.39 5.43e-14 Subjective well-being; LUSC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.14 0.64 8.69e-40 Intelligence (multi-trait analysis); LUSC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg26116260 chr4:7069785 GRPEL1 -1.0 -12.27 -0.56 7.97e-29 Monocyte percentage of white cells; LUSC cis rs10832963 1.000 rs10128711 chr11:18632984 A/G cg20219074 chr11:18656078 SPTY2D1 0.73 10.97 0.51 4.22e-24 Breast cancer; LUSC cis rs3096299 0.967 rs2965830 chr16:89460290 T/C cg00750074 chr16:89608354 SPG7 -0.47 -8.24 -0.41 4.05e-15 Multiple myeloma (IgH translocation); LUSC cis rs11931598 0.511 rs4689576 chr4:7025523 T/C cg26116260 chr4:7069785 GRPEL1 0.47 6.95 0.36 1.93e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC trans rs1493916 0.606 rs10432168 chr18:31312106 T/C cg27147174 chr7:100797783 AP1S1 -0.51 -7.98 -0.4 2.42e-14 Life satisfaction; LUSC cis rs7246967 0.673 rs34682021 chr19:22826728 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs9467773 0.620 rs2494700 chr6:26631306 C/T cg09904177 chr6:26538194 HMGN4 0.65 11.7 0.54 9.83e-27 Intelligence (multi-trait analysis); LUSC cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg17143192 chr8:8559678 CLDN23 0.64 9.02 0.44 1.47e-17 Obesity-related traits; LUSC cis rs3008870 1.000 rs2065001 chr1:67486509 C/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.21 0.64 4.77e-40 Lymphocyte percentage of white cells; LUSC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg09034736 chr1:150693464 HORMAD1 0.42 5.85 0.3 1.16e-8 Melanoma; LUSC cis rs9467773 0.526 rs12199613 chr6:26367218 C/T cg05738196 chr6:26577821 NA -0.47 -7.28 -0.37 2.42e-12 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg10729496 chr3:10149963 C3orf24 0.52 7.11 0.36 7.19e-12 Alzheimer's disease; LUSC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg04546413 chr19:29218101 NA 0.72 11.5 0.53 5.38e-26 Methadone dose in opioid dependence; LUSC cis rs6456156 0.586 rs6456149 chr6:167463902 T/C cg06454157 chr6:167490870 NA -0.27 -6.67 -0.34 1.07e-10 Primary biliary cholangitis; LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg07404485 chr7:94953653 PON1 -0.3 -5.88 -0.31 1.02e-8 Paraoxonase activity; LUSC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.94 0.44 2.8e-17 Menopause (age at onset); LUSC cis rs9462027 0.583 rs6937784 chr6:34644276 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.21 -0.32 1.53e-9 Systemic lupus erythematosus; LUSC cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg21016266 chr12:122356598 WDR66 0.62 9.27 0.45 2.35e-18 Mean corpuscular volume; LUSC cis rs983392 0.836 rs7935829 chr11:59942815 A/G cg02771260 chr11:59836817 MS4A3 -0.38 -6.16 -0.32 2.11e-9 Alzheimer's disease (late onset); LUSC cis rs7829975 0.606 rs10112585 chr8:8795030 A/T cg15556689 chr8:8085844 FLJ10661 -0.6 -9.97 -0.48 1.17e-20 Mood instability; LUSC cis rs10782582 0.593 rs4638068 chr1:76161663 G/A cg03433033 chr1:76189801 ACADM -0.46 -6.88 -0.35 2.95e-11 Daytime sleep phenotypes; LUSC cis rs1559088 0.895 rs13345542 chr19:33586739 G/C cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.38e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs41271473 0.526 rs12094319 chr1:228717836 G/C cg10167378 chr1:228756711 NA 0.76 9.72 0.47 8.12e-20 Chronic lymphocytic leukemia; LUSC cis rs36715 1.000 rs36715 chr5:127562880 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.41 5.87 0.31 1.05e-8 Breast cancer; LUSC cis rs7119 0.717 rs11631274 chr15:77816431 A/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs9341808 0.727 rs1324120 chr6:80976125 G/C cg08355045 chr6:80787529 NA 0.56 9.76 0.47 5.61e-20 Sitting height ratio; LUSC cis rs9549367 0.789 rs12584008 chr13:113881228 C/T cg18105134 chr13:113819100 PROZ -0.69 -9.77 -0.47 5.23e-20 Platelet distribution width; LUSC cis rs12973672 1.000 rs10421599 chr19:35767933 G/A cg12095397 chr19:35769544 USF2 0.44 6.92 0.35 2.37e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7512552 0.803 rs2454286 chr1:150355538 G/A cg15654264 chr1:150340011 RPRD2 0.62 10.12 0.48 3.62e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.67 0.3 3.16e-8 Rheumatoid arthritis; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg17647192 chr12:65563900 LEMD3 0.43 6.34 0.33 7.37e-10 N-glycan levels; LUSC cis rs9325144 0.647 rs12227834 chr12:38849246 G/C cg26384229 chr12:38710491 ALG10B -0.61 -9.24 -0.45 2.95e-18 Morning vs. evening chronotype; LUSC cis rs208520 0.690 rs12201156 chr6:66720874 G/T cg07460842 chr6:66804631 NA 1.07 16.47 0.67 5.03e-45 Exhaled nitric oxide output; LUSC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg12463550 chr7:65579703 CRCP -0.57 -8.46 -0.42 8.37e-16 Aortic root size; LUSC cis rs7000551 0.581 rs4872487 chr8:22256414 C/T cg12081754 chr8:22256438 SLC39A14 0.99 16.38 0.67 1.08e-44 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs7944735 0.507 rs7934659 chr11:48066374 C/T cg15704280 chr7:45808275 SEPT13 0.61 7.31 0.37 2.04e-12 Intraocular pressure; LUSC cis rs4363385 0.574 rs4845503 chr1:152959939 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -6.01 -0.31 4.98e-9 Inflammatory skin disease; LUSC cis rs6163 0.588 rs11191392 chr10:104526951 C/A cg23093090 chr10:104574429 C10orf26 -0.41 -7.81 -0.39 7.36e-14 Waist circumference;Hip circumference; LUSC trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -15.51 -0.65 3.07e-41 Coronary artery disease; LUSC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11644478 chr21:40555479 PSMG1 -0.78 -13.64 -0.6 5.72e-34 Cognitive function; LUSC cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg05347473 chr6:146136440 FBXO30 0.54 9.34 0.46 1.36e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303401 0.614 rs2333409 chr17:57139134 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.8 12.18 0.55 1.72e-28 Cognitive test performance; LUSC cis rs1018836 0.923 rs10956720 chr8:91576222 C/T cg16814680 chr8:91681699 NA -0.76 -13.02 -0.58 1.27e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs747782 0.527 rs2270993 chr11:48145166 G/A cg03929089 chr4:120376271 NA 0.71 6.42 0.33 4.63e-10 Intraocular pressure; LUSC cis rs936229 0.813 rs7085 chr15:75095483 T/C cg14664628 chr15:75095509 CSK -1.02 -18.12 -0.7 1.35e-51 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs11229555 0.574 rs12271501 chr11:58214969 T/C cg15696309 chr11:58395628 NA -0.64 -7.83 -0.39 6.55e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs662064 0.962 rs648324 chr1:10556447 G/T cg20482658 chr1:10539492 PEX14 -0.34 -6.88 -0.35 2.94e-11 Asthma; LUSC cis rs13385 0.728 rs10055141 chr5:139616609 T/C cg26211634 chr5:139558579 C5orf32 0.46 7.05 0.36 1.04e-11 Atrial fibrillation; LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.28 -0.32 1.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg03713592 chr11:72463424 ARAP1 0.49 6.81 0.35 4.45e-11 Body mass index; LUSC cis rs9646954 0.542 rs4149512 chr2:101022886 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.86 -0.44 4.94e-17 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.21 -0.37 3.86e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg18252515 chr7:66147081 NA -1.19 -12.97 -0.58 2.03e-31 Diabetic kidney disease; LUSC cis rs738322 0.967 rs132985 chr22:38563471 C/T cg25457927 chr22:38595422 NA -0.38 -7.86 -0.4 5.22e-14 Cutaneous nevi; LUSC cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs637571 0.565 rs633800 chr11:65638719 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.5 -6.64 -0.34 1.29e-10 Eosinophil percentage of white cells; LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg24675658 chr1:53192096 ZYG11B -0.57 -8.85 -0.44 5.19e-17 Monocyte count; LUSC cis rs9905704 0.846 rs7212271 chr17:56863918 C/T cg12560992 chr17:57184187 TRIM37 0.58 8.38 0.42 1.5e-15 Testicular germ cell tumor; LUSC cis rs4629180 0.562 rs10198901 chr2:102127937 G/A cg04415270 chr2:102091202 RFX8 -0.44 -7.76 -0.39 1.05e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg18404041 chr3:52824283 ITIH1 -0.57 -11.1 -0.52 1.43e-24 Bipolar disorder; LUSC cis rs4253772 0.938 rs75977757 chr22:46641525 G/T cg09491104 chr22:46646882 C22orf40 -0.63 -6.52 -0.34 2.57e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1371867 0.875 rs1619759 chr8:101337560 T/C cg00191853 chr8:101177733 SPAG1 -0.39 -6.37 -0.33 6.33e-10 Atrioventricular conduction; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00232805 chr2:97779565 ANKRD36 0.44 6.93 0.35 2.21e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg18225595 chr11:63971243 STIP1 0.5 6.32 0.33 8.14e-10 Mean platelet volume; LUSC cis rs8060686 0.623 rs7204208 chr16:68069416 A/G cg09835421 chr16:68378352 PRMT7 -0.44 -5.66 -0.3 3.18e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg22166914 chr1:53195759 ZYG11B -0.49 -7.76 -0.39 1.04e-13 Monocyte count; LUSC cis rs62244186 0.535 rs59726036 chr3:44850074 G/T cg02073558 chr3:44770973 ZNF501 0.61 10.19 0.49 1.99e-21 Depressive symptoms; LUSC cis rs6500395 1.000 rs9931737 chr16:48623539 C/T cg04672837 chr16:48644449 N4BP1 0.49 7.28 0.37 2.46e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg12463550 chr7:65579703 CRCP 0.5 7.02 0.36 1.22e-11 Aortic root size; LUSC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg12311346 chr5:56204834 C5orf35 0.93 13.76 0.6 1.93e-34 Initial pursuit acceleration; LUSC cis rs1639906 1.000 rs1637759 chr7:2220053 C/T cg18044113 chr7:2236405 MAD1L1 -0.33 -6.2 -0.32 1.66e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7582180 0.838 rs13024601 chr2:100902032 C/T cg08017756 chr2:100939284 LONRF2 -0.36 -6.16 -0.32 2.12e-9 Intelligence (multi-trait analysis); LUSC trans rs2235573 0.551 rs84770 chr22:38390128 T/G cg19894588 chr14:64061835 NA 0.49 7.1 0.36 7.68e-12 Glioblastoma;Glioma; LUSC trans rs35110281 0.667 rs4819286 chr21:45120121 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.91 0.51 6.48e-24 Mean corpuscular volume; LUSC cis rs7508679 1.000 rs7248104 chr19:7224431 A/G cg09779027 chr19:7224513 INSR 0.46 9.79 0.47 4.74e-20 Hypothyroidism; LUSC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg09035930 chr12:129282057 SLC15A4 0.66 13.23 0.59 1.95e-32 Systemic lupus erythematosus; LUSC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg17279839 chr7:150038598 RARRES2 0.45 6.92 0.35 2.28e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs7829975 0.742 rs882462 chr8:8678530 G/A cg08975724 chr8:8085496 FLJ10661 0.52 7.68 0.39 1.76e-13 Mood instability; LUSC cis rs1371867 0.875 rs1660344 chr8:101324659 A/G cg06002616 chr8:101225028 SPAG1 -0.47 -7.62 -0.38 2.59e-13 Atrioventricular conduction; LUSC trans rs7615952 0.673 rs35001498 chr3:125628644 A/G cg07211511 chr3:129823064 LOC729375 -1.02 -12.63 -0.57 3.59e-30 Blood pressure (smoking interaction); LUSC cis rs3007168 0.711 rs10144823 chr14:51640225 T/C cg23942311 chr14:51606299 NA -0.35 -6.4 -0.33 5.31e-10 Cancer; LUSC cis rs72717009 0.756 rs10494359 chr1:161463876 G/C cg23840854 chr1:161414152 NA -0.9 -11.05 -0.52 2.16e-24 Rheumatoid arthritis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25341937 chr6:17706893 NUP153 -0.53 -6.42 -0.33 4.71e-10 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg08736216 chr1:53307985 ZYG11A -0.29 -6.27 -0.32 1.12e-9 Monocyte count; LUSC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg06112835 chr11:68658793 MRPL21 0.51 7.68 0.39 1.84e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg26304593 chr6:42947056 PEX6 -0.52 -8.12 -0.41 9e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg20243544 chr17:37824526 PNMT 0.39 5.82 0.3 1.37e-8 Self-reported allergy; LUSC cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg03647239 chr10:116582469 FAM160B1 0.47 7.58 0.38 3.35e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1801251 1.000 rs2592113 chr2:233669553 C/T cg25237894 chr2:233734115 C2orf82 0.34 6.29 0.33 9.81e-10 Coronary artery disease; LUSC cis rs950881 0.932 rs72823646 chr2:102954213 G/A cg20060108 chr2:102954350 IL1RL1 0.45 5.9 0.31 8.86e-9 Allergy; LUSC cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs559928 0.606 rs60394481 chr11:63909035 G/A cg05555928 chr11:63887634 MACROD1 -0.48 -6.09 -0.32 3.08e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs17095355 1.000 rs11194923 chr10:111695762 A/G cg00817464 chr10:111662876 XPNPEP1 -0.56 -6.88 -0.35 3.05e-11 Biliary atresia; LUSC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg12564285 chr5:131593104 PDLIM4 0.36 6.93 0.35 2.2e-11 Blood metabolite levels; LUSC cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg07636037 chr3:49044803 WDR6 0.91 13.99 0.61 2.57e-35 Parkinson's disease; LUSC cis rs7180079 0.502 rs6494466 chr15:64508763 A/G cg02848875 chr15:64387786 SNX1 0.4 7.92 0.4 3.63e-14 Monocyte count; LUSC cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg09307838 chr4:120376055 NA 0.78 11.23 0.52 4.68e-25 Corneal astigmatism; LUSC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg24733560 chr20:60626293 TAF4 0.36 5.93 0.31 7.62e-9 Body mass index; LUSC cis rs11764590 0.666 rs3996325 chr7:2053747 T/C cg02825527 chr7:2087843 MAD1L1 -0.46 -5.79 -0.3 1.67e-8 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07237882 chr5:137090689 HNRNPA0 -0.47 -6.25 -0.32 1.25e-9 Bipolar disorder and schizophrenia; LUSC cis rs9287719 0.967 rs759403 chr2:10729897 C/T cg00105475 chr2:10696890 NA 0.37 6.09 0.32 3.03e-9 Prostate cancer; LUSC cis rs76793172 1.000 rs16980059 chr19:46353634 C/T cg27118825 chr19:46318748 RSPH6A;SYMPK 0.45 5.8 0.3 1.54e-8 Eosinophil counts; LUSC cis rs4073582 0.595 rs1151540 chr11:66041807 A/C cg14036092 chr11:66035641 RAB1B 0.44 6.31 0.33 9.07e-10 Gout; LUSC cis rs1448094 0.967 rs7301496 chr12:86321212 A/C cg00310523 chr12:86230176 RASSF9 0.39 6.99 0.36 1.53e-11 Major depressive disorder; LUSC cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg06784218 chr1:46089804 CCDC17 -0.52 -9.87 -0.48 2.51e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg13939156 chr17:80058883 NA 0.33 6.46 0.33 3.73e-10 Life satisfaction; LUSC cis rs12155623 0.592 rs12682003 chr8:49865454 G/T cg22283653 chr8:49824208 NA 0.32 6.2 0.32 1.62e-9 Sudden cardiac arrest; LUSC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg00750074 chr16:89608354 SPG7 -0.46 -7.04 -0.36 1.08e-11 Multiple myeloma (IgH translocation); LUSC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg06713675 chr4:122721982 EXOSC9 -0.7 -12.04 -0.55 5.88e-28 Type 2 diabetes; LUSC cis rs10465746 0.967 rs12759527 chr1:84434425 T/C cg10977910 chr1:84465055 TTLL7 0.42 6.23 0.32 1.41e-9 Obesity-related traits; LUSC trans rs12043259 0.502 rs4951111 chr1:204725646 C/T cg06849515 chr4:13549607 LOC285548 -0.63 -6.29 -0.33 9.95e-10 Addiction; LUSC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg21856205 chr7:94953877 PON1 -0.36 -5.81 -0.3 1.45e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1865760 0.566 rs7772312 chr6:26049616 G/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.9 0.4 4.01e-14 Height; LUSC cis rs6690583 0.623 rs12037219 chr1:85505951 G/A cg11262906 chr1:85462892 MCOLN2 0.63 5.99 0.31 5.34e-9 Serum sulfate level; LUSC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs12579753 1.000 rs7966755 chr12:82221604 A/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.18e-9 Resting heart rate; LUSC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg22467129 chr15:76604101 ETFA -0.51 -8.18 -0.41 5.92e-15 Blood metabolite levels; LUSC cis rs5769707 0.554 rs10854876 chr22:50010570 T/C cg05373962 chr22:49881684 NA -0.41 -8.54 -0.42 4.99e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11645898 0.745 rs72787062 chr16:72105844 G/A cg14768367 chr16:72042858 DHODH -0.66 -7.3 -0.37 2.18e-12 Blood protein levels; LUSC cis rs10761482 0.861 rs4600155 chr10:62101381 T/A cg18175470 chr10:62150864 ANK3 -0.52 -7.44 -0.38 8.5e-13 Schizophrenia; LUSC cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg11266682 chr4:10021025 SLC2A9 -0.5 -8.45 -0.42 8.83e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4903604 0.560 rs4903605 chr14:78035619 C/T cg18872420 chr14:78023429 SPTLC2 0.38 5.94 0.31 7.06e-9 Gut microbiome composition (winter); LUSC cis rs59698941 0.943 rs67952459 chr5:132297902 C/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg12442385 chr7:1034912 NA -0.36 -6.19 -0.32 1.8e-9 Longevity;Endometriosis; LUSC cis rs28374715 0.681 rs7163989 chr15:41614621 A/G cg18705301 chr15:41695430 NDUFAF1 -0.92 -18.25 -0.71 4.09e-52 Ulcerative colitis; LUSC cis rs9300255 0.739 rs4759415 chr12:123743674 C/T cg05973401 chr12:123451056 ABCB9 -0.52 -6.51 -0.34 2.69e-10 Neutrophil percentage of white cells; LUSC cis rs7945718 0.934 rs10831905 chr11:12776467 C/T cg25843174 chr11:12811716 TEAD1 -0.31 -6.83 -0.35 4.01e-11 Educational attainment (years of education); LUSC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 9.91e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.09 0.58 6.67e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2274273 1.000 rs2075603 chr14:55609955 C/A cg04306507 chr14:55594613 LGALS3 0.54 11.53 0.53 3.94e-26 Protein biomarker; LUSC cis rs9527 0.590 rs10786744 chr10:104945028 A/C cg05855489 chr10:104503620 C10orf26 -0.53 -8.21 -0.41 4.73e-15 Arsenic metabolism; LUSC cis rs8060686 0.641 rs73612208 chr16:68206844 G/A cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs72781680 0.752 rs7578606 chr2:23902360 T/C cg08917208 chr2:24149416 ATAD2B 0.98 9.69 0.47 9.64e-20 Lymphocyte counts; LUSC cis rs6084875 0.840 rs2422933 chr20:4720035 T/C cg26097573 chr20:4721490 PRNT -0.31 -5.71 -0.3 2.44e-8 Systemic lupus erythematosus; LUSC cis rs4077515 0.806 rs3812564 chr9:139271190 A/G cg14169450 chr9:139327907 INPP5E 0.42 7.5 0.38 5.93e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6456156 0.586 rs2017338 chr6:167471714 G/A cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs7674212 0.541 rs2045746 chr4:104083578 A/C cg16532752 chr4:104119610 CENPE 0.47 6.71 0.34 8.55e-11 Type 2 diabetes; LUSC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs2180341 0.566 rs982306 chr6:127777039 T/C cg27446573 chr6:127587934 RNF146 0.57 8.55 0.42 4.54e-16 Breast cancer; LUSC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12667521 chr19:29218732 NA 0.62 8.99 0.44 1.87e-17 Methadone dose in opioid dependence; LUSC cis rs4141404 0.851 rs5997893 chr22:31556103 A/G cg22777020 chr22:31556080 RNF185 -0.49 -6.66 -0.34 1.15e-10 Paclitaxel-induced neuropathy; LUSC cis rs6565180 0.926 rs4787643 chr16:30393660 G/A cg17640201 chr16:30407289 ZNF48 0.9 15.41 0.64 7.41e-41 Tonsillectomy; LUSC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg03351412 chr1:154909251 PMVK 0.52 8.08 0.4 1.22e-14 Prostate cancer; LUSC trans rs6502050 0.835 rs66531647 chr17:80089022 G/T cg07393940 chr7:158741817 NA 0.37 6.7 0.34 8.88e-11 Life satisfaction; LUSC cis rs1385374 1.000 rs1385374 chr12:129300694 C/T cg09035930 chr12:129282057 SLC15A4 -0.58 -6.34 -0.33 7.39e-10 Systemic lupus erythematosus; LUSC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg08798685 chr6:27730294 NA -0.63 -5.88 -0.31 1.01e-8 Depression; LUSC cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.44 0.65 5.67e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.07e-17 Prudent dietary pattern; LUSC trans rs2243480 1.000 rs2707831 chr7:66062511 G/A cg10756647 chr7:56101905 PSPH 0.88 8.95 0.44 2.46e-17 Diabetic kidney disease; LUSC cis rs477692 1.000 rs558764 chr10:131426957 G/T cg26102564 chr10:131424627 MGMT -0.4 -6.26 -0.32 1.2e-9 Response to temozolomide; LUSC trans rs11039798 0.614 rs11039954 chr11:48741818 A/G cg15704280 chr7:45808275 SEPT13 0.81 7.73 0.39 1.27e-13 Axial length; LUSC trans rs1005277 0.563 rs2505215 chr10:38481273 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.15 -0.45 5.6e-18 Extrinsic epigenetic age acceleration; LUSC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg24879335 chr3:133465180 TF -0.46 -8.1 -0.41 1.01e-14 Iron status biomarkers (transferrin levels); LUSC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg18252515 chr7:66147081 NA -1.23 -13.29 -0.59 1.17e-32 Diabetic kidney disease; LUSC cis rs57920188 0.584 rs12068729 chr1:4091650 A/G cg20703997 chr1:4087676 NA 0.56 8.33 0.41 2.12e-15 Interleukin-17 levels; LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg07217954 chr7:1067459 C7orf50 0.54 5.71 0.3 2.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4555082 1.000 rs4334224 chr14:105759198 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.72 -0.39 1.36e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs7582180 0.652 rs4851311 chr2:100980398 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.76 -0.43 9.63e-17 Intelligence (multi-trait analysis); LUSC cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.76 -0.35 6.21e-11 Menopause (age at onset); LUSC cis rs765787 0.556 rs10851422 chr15:45513738 T/C cg24006582 chr15:45444508 DUOX1 0.67 9.67 0.47 1.16e-19 Uric acid levels; LUSC cis rs66887589 0.616 rs11731675 chr4:120212514 T/C cg13609457 chr4:120235615 NA 0.37 5.7 0.3 2.61e-8 Diastolic blood pressure; LUSC cis rs870825 0.616 rs7681824 chr4:185617525 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.29 0.59 1.2e-32 Blood protein levels; LUSC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg00800038 chr16:89945340 TCF25 -0.66 -6.82 -0.35 4.41e-11 Skin colour saturation; LUSC trans rs2840044 1.000 rs11653310 chr17:33893378 C/G cg19694781 chr19:47549865 TMEM160 -0.57 -9.41 -0.46 8.09e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs13217239 0.646 rs7451149 chr6:27057518 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -6.03 -0.31 4.23e-9 Schizophrenia; LUSC trans rs62458065 0.513 rs787220 chr7:32581139 C/G cg00845942 chr12:64062724 DPY19L2 -0.62 -7.97 -0.4 2.45e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -14.2 -0.61 3.99e-36 Hemoglobin concentration; LUSC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg18904891 chr8:8559673 CLDN23 -0.61 -8.47 -0.42 8.17e-16 Obesity-related traits; LUSC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg12963246 chr6:28129442 ZNF389 0.48 6.55 0.34 2.12e-10 Depression; LUSC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg15369054 chr17:80825471 TBCD 0.68 11.02 0.52 2.78e-24 Breast cancer; LUSC cis rs477692 0.685 rs534430 chr10:131398734 A/C cg11019008 chr10:131425282 MGMT 0.45 6.7 0.34 8.92e-11 Response to temozolomide; LUSC cis rs11077998 0.935 rs11653926 chr17:80484953 G/A cg10255544 chr17:80519551 FOXK2 0.39 6.38 0.33 5.79e-10 Reticulocyte fraction of red cells; LUSC cis rs738322 0.967 rs4383 chr22:38570927 C/G cg25457927 chr22:38595422 NA -0.42 -8.92 -0.44 3.05e-17 Cutaneous nevi; LUSC cis rs28374715 0.617 rs16971735 chr15:41563970 C/G cg18705301 chr15:41695430 NDUFAF1 -0.63 -11.24 -0.52 4.3e-25 Ulcerative colitis; LUSC trans rs724744 0.772 rs1205913 chr6:22371494 A/G cg13807341 chr11:118445984 ARCN1 0.35 6.1 0.32 2.88e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 3.03e-15 Tonsillectomy; LUSC trans rs11039798 0.764 rs2089208 chr11:48899860 C/T cg15704280 chr7:45808275 SEPT13 0.79 7.49 0.38 6.36e-13 Axial length; LUSC cis rs8048589 0.515 rs12443524 chr16:12239979 A/G cg02910054 chr16:12241554 SNX29 -0.49 -7.05 -0.36 1.06e-11 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs8113142 0.651 rs16961698 chr19:29111032 T/C cg04546413 chr19:29218101 NA 0.42 5.76 0.3 1.96e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.16 0.61 5.72e-36 Platelet count; LUSC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg05855489 chr10:104503620 C10orf26 0.59 9.45 0.46 6.25e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12950390 0.853 rs8078052 chr17:45859434 A/G cg03474202 chr17:45855739 NA -0.3 -6.93 -0.35 2.14e-11 IgG glycosylation; LUSC cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg06026331 chr20:60912101 LAMA5 -0.56 -6.78 -0.35 5.63e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs8062405 0.965 rs7359397 chr16:28885659 C/T cg05966235 chr16:28915196 ATP2A1 0.34 5.96 0.31 6.43e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs950776 0.720 rs11637890 chr15:78935419 C/G cg06917634 chr15:78832804 PSMA4 -0.6 -8.96 -0.44 2.37e-17 Sudden cardiac arrest; LUSC cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg23711669 chr6:146136114 FBXO30 0.92 17.68 0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18802885 chr22:26908376 TFIP11 0.43 6.31 0.33 9.06e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6723108 0.713 rs6728095 chr2:135376072 T/A cg12500956 chr2:135428796 TMEM163 -0.29 -6.78 -0.35 5.44e-11 Type 2 diabetes; LUSC cis rs6547741 0.717 rs2178197 chr2:27860551 C/T cg12559939 chr2:27858050 GPN1 0.39 5.99 0.31 5.52e-9 Oral cavity cancer; LUSC cis rs6714710 0.627 rs11680883 chr2:98472610 T/C cg26665480 chr2:98280029 ACTR1B 0.64 9.21 0.45 3.6e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs9886428 1.000 rs34786320 chr8:14115490 G/C cg19037007 chr20:741798 C20orf54 -0.39 -6.11 -0.32 2.77e-9 IgG glycosylation; LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC cis rs6061231 0.505 rs13037253 chr20:60928724 G/A cg03359095 chr20:61002866 C20orf151 -0.3 -5.83 -0.3 1.29e-8 Colorectal cancer; LUSC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg12751644 chr20:60527061 NA 0.37 6.4 0.33 5.25e-10 Body mass index; LUSC cis rs9902453 0.808 rs1986555 chr17:28014448 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.49 0.46 4.69e-19 Coffee consumption (cups per day); LUSC cis rs4665630 0.522 rs2712100 chr2:23931925 A/T cg08063864 chr2:24346004 PFN4;LOC375190 -0.81 -7.26 -0.37 2.79e-12 Hypertension; LUSC cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg15073853 chr19:18549131 ISYNA1 -0.33 -6.16 -0.32 2.13e-9 Breast cancer; LUSC cis rs77633900 0.614 rs280014 chr15:76986890 A/G cg21673338 chr15:77095150 SCAPER -0.81 -8.23 -0.41 4.3e-15 Non-glioblastoma glioma;Glioma; LUSC cis rs6977660 0.714 rs2390157 chr7:19786177 G/A cg07541023 chr7:19748670 TWISTNB 0.67 6.71 0.34 8.19e-11 Thyroid stimulating hormone; LUSC cis rs6686643 1.000 rs6686643 chr1:165616588 T/C cg16553119 chr1:165599451 MGST3 -0.46 -6.73 -0.35 7.28e-11 Total ventricular volume; LUSC cis rs4423214 1.000 rs11606612 chr11:71164047 C/A cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs9653442 0.564 rs11902705 chr2:100795207 A/G cg07810366 chr2:100720526 AFF3 0.41 6.98 0.36 1.57e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4808199 0.947 rs754255 chr19:19578890 T/C cg03709012 chr19:19516395 GATAD2A 1.08 14.22 0.61 3.19e-36 Nonalcoholic fatty liver disease; LUSC cis rs2580764 0.566 rs2972075 chr2:55292322 T/G cg09592903 chr2:55203963 RTN4 0.48 9.85 0.47 2.91e-20 Mean platelet volume; LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg10729496 chr3:10149963 C3orf24 0.52 6.88 0.35 2.9100000000000002e-11 Alzheimer's disease; LUSC cis rs6725041 0.547 rs17419211 chr2:213207921 C/T cg16329650 chr2:213403929 ERBB4 -0.43 -6.71 -0.34 8.3e-11 QT interval (ambient particulate matter interaction); LUSC trans rs11992162 0.967 rs7836456 chr8:11829175 T/G cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.36e-15 Monocyte count; LUSC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 10.66 0.5 4.87e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -5.99 -0.31 5.28e-9 Platelet count; LUSC cis rs6424115 0.729 rs1737362 chr1:24054800 T/C cg10978503 chr1:24200527 CNR2 0.47 10.39 0.49 4.37e-22 Immature fraction of reticulocytes; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.67 0.6 4.39e-34 Alzheimer's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11251232 chr1:93811340 DR1 0.73 6.38 0.33 5.85e-10 Cognitive performance; LUSC cis rs3858526 0.834 rs7125244 chr11:5980359 T/C cg25319279 chr11:5960081 NA -0.46 -6.46 -0.33 3.71e-10 DNA methylation (variation); LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg00166722 chr3:10149974 C3orf24 0.55 7.46 0.38 7.77e-13 Alzheimer's disease; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.11e-9 Menopause (age at onset); LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg02475777 chr4:1388615 CRIPAK 0.62 9.23 0.45 3.15e-18 Longevity; LUSC trans rs3857536 0.673 rs7759888 chr6:66891922 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC cis rs2742417 0.603 rs13059502 chr3:45781380 A/G cg04837898 chr3:45731254 SACM1L -0.45 -7.45 -0.38 8.27e-13 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs72674100 1.000 rs2865776 chr4:97971736 C/T cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg07507251 chr3:52567010 NT5DC2 0.34 6.66 0.34 1.1e-10 Bipolar disorder; LUSC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg02475777 chr4:1388615 CRIPAK 0.42 6.33 0.33 7.85e-10 Obesity-related traits; LUSC cis rs1728785 1.000 rs1170445 chr16:68573064 G/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.24 0.52 4.35e-25 Menopause (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19698570 chr19:3500953 DOHH 0.79 6.51 0.34 2.79e-10 Cognitive performance; LUSC cis rs28374715 0.532 rs11070328 chr15:41651569 T/C cg18705301 chr15:41695430 NDUFAF1 -1.05 -23.22 -0.79 1.12e-71 Ulcerative colitis; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg00166722 chr3:10149974 C3orf24 0.6 8.12 0.41 9.32e-15 Alzheimer's disease; LUSC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg19774624 chr17:42201019 HDAC5 0.7 10.38 0.49 4.71e-22 Total body bone mineral density; LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg22868518 chr11:507468 RNH1 -0.63 -5.92 -0.31 7.8e-9 Body mass index; LUSC cis rs6840360 0.530 rs11946622 chr4:152486018 C/T cg22705602 chr4:152727874 NA -0.33 -6.48 -0.33 3.37e-10 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.534 rs10844732 chr12:34037104 A/C cg13010199 chr12:38710504 ALG10B 0.55 8.36 0.42 1.74e-15 Morning vs. evening chronotype; LUSC cis rs9341808 0.718 rs910266 chr6:80921170 A/T cg08355045 chr6:80787529 NA 0.58 10.2 0.49 1.97e-21 Sitting height ratio; LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13126279 chr21:47581558 C21orf56 -0.55 -8.41 -0.42 1.21e-15 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs2204008 0.660 rs2320745 chr12:38239101 T/C cg26384229 chr12:38710491 ALG10B 0.88 15.06 0.64 1.84e-39 Bladder cancer; LUSC cis rs1003719 0.667 rs8127148 chr21:38481292 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.68 10.93 0.51 5.78e-24 Eye color traits; LUSC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.44 0.38 8.35e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12971120 0.891 rs2303463 chr18:72168608 G/A cg26446133 chr18:72167187 CNDP2 -0.81 -9.95 -0.48 1.35e-20 Refractive error; LUSC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg23630131 chr7:65973040 NA 0.21 5.79 0.3 1.6e-8 Aortic root size; LUSC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.94 0.4 3.02e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg17366294 chr4:99064904 C4orf37 0.6 10.71 0.51 3.43e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1559088 0.948 rs10410778 chr19:33592301 C/A cg03563238 chr19:33554763 RHPN2 -0.4 -6.47 -0.33 3.46e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9467773 0.626 rs9379860 chr6:26370605 T/C cg05738196 chr6:26577821 NA -0.49 -7.55 -0.38 4.29e-13 Intelligence (multi-trait analysis); LUSC cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg12219531 chr12:120966889 COQ5 0.68 9.28 0.45 2.19e-18 High light scatter reticulocyte count; LUSC cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs7246657 0.943 rs4452075 chr19:37879589 A/G cg23950597 chr19:37808831 NA -0.62 -7.63 -0.39 2.54e-13 Coronary artery calcification; LUSC trans rs7259376 0.936 rs55983151 chr19:22552936 T/A cg08058610 chr19:52674483 ZNF836 0.38 5.95 0.31 6.93e-9 Menopause (age at onset); LUSC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg06873352 chr17:61820015 STRADA 0.56 8.73 0.43 1.25e-16 Height; LUSC cis rs977987 0.843 rs12443834 chr16:75438469 C/T cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.8e-17 Dupuytren's disease; LUSC trans rs1814175 0.645 rs28441045 chr11:50048971 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs1728785 1.000 rs8058145 chr16:68584090 G/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.17e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs11098499 0.820 rs6534140 chr4:120455311 C/T cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs17095355 0.818 rs12572438 chr10:111769236 T/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -6.85 -0.35 3.58e-11 Biliary atresia; LUSC trans rs17685 0.884 rs6978677 chr7:75636240 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 15.59 0.65 1.45e-41 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg21918786 chr6:109611834 NA -0.42 -7.29 -0.37 2.21e-12 Reticulocyte fraction of red cells; LUSC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg08847533 chr14:75593920 NEK9 0.84 15.46 0.65 4.83e-41 Height; LUSC cis rs11098499 0.863 rs3733525 chr4:120447048 A/G cg24375607 chr4:120327624 NA 0.76 11.14 0.52 1e-24 Corneal astigmatism; LUSC trans rs11098499 1.000 rs13116504 chr4:120209412 A/C cg25214090 chr10:38739885 LOC399744 0.45 6.52 0.34 2.58e-10 Corneal astigmatism; LUSC cis rs7191700 0.673 rs12325495 chr16:11418328 C/T cg00044050 chr16:11439710 C16orf75 0.75 14.14 0.61 6.59e-36 Multiple sclerosis; LUSC cis rs8179 0.552 rs2888877 chr7:92228400 C/T cg15732164 chr7:92237376 CDK6 -0.48 -6.54 -0.34 2.25e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs36093844 0.752 rs1445505 chr11:85584722 A/G cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs12310956 0.532 rs10844707 chr12:33936089 T/C cg26384229 chr12:38710491 ALG10B 0.75 11.87 0.54 2.4200000000000002e-27 Morning vs. evening chronotype; LUSC cis rs11030122 0.604 rs10835557 chr11:4083121 A/G cg18678763 chr11:4115507 RRM1 -0.46 -6.23 -0.32 1.38e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.48 7.46 0.38 7.64e-13 Colorectal cancer; LUSC cis rs72781680 1.000 rs17762782 chr2:24126493 A/G cg08917208 chr2:24149416 ATAD2B 0.89 10.1 0.48 4.26e-21 Lymphocyte counts; LUSC cis rs4285028 0.948 rs34837785 chr3:121657776 G/A cg11130432 chr3:121712080 ILDR1 -0.64 -9.86 -0.47 2.62e-20 Multiple sclerosis; LUSC cis rs7937682 1.000 rs4936661 chr11:111587495 G/A cg19812747 chr11:111475976 SIK2 0.52 6.93 0.35 2.19e-11 Primary sclerosing cholangitis; LUSC cis rs4595586 0.525 rs11613788 chr12:39390710 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs6121246 0.529 rs6058196 chr20:30194714 A/T cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs672059 0.565 rs525410 chr1:183176430 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.41 -6.02 -0.31 4.7e-9 Hypertriglyceridemia; LUSC cis rs17253792 0.732 rs8017891 chr14:56172967 A/G cg01858014 chr14:56050164 KTN1 0.71 6.28 0.33 1.03e-9 Putamen volume; LUSC cis rs4974559 1.000 rs1882099 chr4:1352685 A/G cg02980000 chr4:1222292 CTBP1 0.7 7.94 0.4 3.16e-14 Systolic blood pressure; LUSC trans rs8073060 0.586 rs225300 chr17:33922428 C/T cg19694781 chr19:47549865 TMEM160 -1.12 -17.91 -0.7 9.17e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs748404 0.660 rs2602141 chr15:43724646 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.38 5.69 0.3 2.85e-8 Lung cancer; LUSC trans rs17039065 1.000 rs16996969 chr4:109382668 A/T cg07444054 chr2:108107501 NA 0.43 6.27 0.32 1.1e-9 Gut microbiome composition (summer); LUSC trans rs6427908 0.535 rs481298 chr1:201430436 C/T cg19931106 chr2:37311892 CCDC75;HEATR5B 0.41 6.16 0.32 2.13e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.81 -0.39 7.56e-14 Neuroticism; LUSC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg10523679 chr1:76189770 ACADM 0.89 15.95 0.66 5.74e-43 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg06454157 chr6:167490870 NA -0.25 -6.29 -0.33 1.01e-9 Crohn's disease; LUSC trans rs6828577 0.560 rs114938210 chr4:119457257 A/T cg26518628 chr1:97050305 NA -0.52 -7.58 -0.38 3.34e-13 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC trans rs11723530 0.512 rs6848359 chr4:170815842 C/T cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.15 -0.32 2.19e-9 Myopia (pathological); LUSC cis rs727505 0.521 rs66787780 chr7:124791849 G/A cg23710748 chr7:124431027 NA -0.4 -6.98 -0.36 1.61e-11 Lewy body disease; LUSC cis rs7577851 0.715 rs6759021 chr2:69632620 T/C cg10773587 chr2:69614142 GFPT1 0.56 6.3 0.33 9.29e-10 Parkinson's disease (age of onset); LUSC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -12.63 -0.57 3.54e-30 Extrinsic epigenetic age acceleration; LUSC cis rs12682352 0.602 rs28399241 chr8:8663215 C/T cg06636001 chr8:8085503 FLJ10661 0.57 8.17 0.41 6.49e-15 Neuroticism; LUSC cis rs2835872 0.965 rs1787331 chr21:39003525 T/G cg20424643 chr21:39039972 KCNJ6 -0.39 -5.91 -0.31 8.28e-9 Electroencephalographic traits in alcoholism; LUSC cis rs751728 1.000 rs751728 chr6:33764033 C/T cg25922239 chr6:33757077 LEMD2 0.54 8.02 0.4 1.78e-14 Crohn's disease; LUSC cis rs34891900 0.507 rs12167823 chr22:18124362 G/A cg19898043 chr22:18121309 BCL2L13 0.41 6.26 0.32 1.18e-9 Sum neutrophil eosinophil counts; LUSC cis rs734999 0.549 rs2764845 chr1:2528999 G/T cg18854424 chr1:2615690 NA -0.52 -10.62 -0.5 6.92e-23 Ulcerative colitis; LUSC cis rs62458065 0.850 rs62458099 chr7:32472395 C/T cg20159608 chr7:32802032 NA -0.66 -7.83 -0.39 6.35e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg14061069 chr19:46274453 DMPK -0.49 -8.32 -0.41 2.34e-15 Coronary artery disease; LUSC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg02569458 chr12:86230093 RASSF9 0.57 9.47 0.46 5.46e-19 Major depressive disorder; LUSC cis rs9814567 1.000 rs17694011 chr3:134213981 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.75 -0.6 2.1e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg20607287 chr7:12443886 VWDE -0.65 -6.34 -0.33 7.48e-10 Coronary artery disease; LUSC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs11190604 0.806 rs76835764 chr10:102193612 C/T cg07080220 chr10:102295463 HIF1AN 0.61 8.14 0.41 8.11e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg10645314 chr2:3704589 ALLC -0.49 -7.33 -0.37 1.72e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs6835098 0.961 rs17322893 chr4:174122556 A/G cg08422745 chr4:174089978 GALNT7 0.81 13.22 0.59 2.12e-32 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg15448220 chr1:150897856 SETDB1 0.42 5.86 0.31 1.09e-8 Urate levels; LUSC cis rs10045504 0.502 rs72746038 chr5:38753999 G/A cg15396434 chr5:38725168 NA -0.51 -5.79 -0.3 1.61e-8 Night sleep phenotypes; LUSC cis rs1065852 0.526 rs9611711 chr22:42410695 G/A cg22189786 chr22:42395067 WBP2NL 0.43 5.77 0.3 1.78e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3126085 0.935 rs6587651 chr1:152193121 G/T cg26876637 chr1:152193138 HRNR 0.44 6.4 0.33 5.27e-10 Atopic dermatitis; LUSC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.8 0.3 1.56e-8 Personality dimensions; LUSC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg18827107 chr12:86230957 RASSF9 0.46 6.98 0.36 1.65e-11 Major depressive disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18441082 chr5:16466057 ZNF622 0.42 6.27 0.32 1.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC trans rs17495987 0.871 rs73061231 chr7:7904396 T/C cg25844211 chr1:229761456 URB2;TAF5L 0.45 6.05 0.31 3.83e-9 Tonsillectomy; LUSC trans rs7824557 0.603 rs7016671 chr8:11182455 A/G cg06636001 chr8:8085503 FLJ10661 0.43 6.27 0.32 1.11e-9 Retinal vascular caliber; LUSC cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg00074818 chr8:8560427 CLDN23 0.59 9.92 0.48 1.71e-20 Obesity-related traits; LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg02353165 chr6:42928485 GNMT 0.66 11.38 0.53 1.45e-25 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs554111 0.656 rs10916930 chr1:21395357 C/T cg01072550 chr1:21505969 NA -0.37 -5.68 -0.3 2.92e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg19468946 chr17:37922297 IKZF3 -0.43 -6.86 -0.35 3.45e-11 Self-reported allergy; LUSC cis rs1577917 0.958 rs12213343 chr6:86443019 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.69e-11 Response to antipsychotic treatment; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03087852 chr16:30969112 SETD1A 0.78 6.13 0.32 2.47e-9 Cognitive performance; LUSC cis rs6066835 1.000 rs6095272 chr20:47357517 A/G cg18078177 chr20:47281410 PREX1 0.75 6.44 0.33 4.14e-10 Multiple myeloma; LUSC cis rs6942756 1.000 rs6974155 chr7:128914545 C/G cg02491457 chr7:128862824 NA -0.53 -7.63 -0.39 2.4e-13 White matter hyperintensity burden; LUSC cis rs11122272 0.735 rs2808591 chr1:231523421 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC trans rs2302464 1.000 rs111541714 chr4:15730405 C/A cg17675199 chr6:35436792 RPL10A -0.88 -6.15 -0.32 2.26e-9 Cerebrospinal fluid biomarker levels; LUSC trans rs35110281 0.782 rs2838329 chr21:45023329 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.32 0.53 2.25e-25 Mean corpuscular volume; LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.44 0.53 8.79e-26 Prudent dietary pattern; LUSC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.05e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs488628 1.000 rs487147 chr3:118135310 A/G cg06621744 chr14:37052470 NKX2-8 -0.29 -6.7 -0.34 8.64e-11 White matter integrity (bipolar disorder risk interaction); LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg22963979 chr7:1858916 MAD1L1 -0.74 -12.57 -0.57 6.08e-30 Bipolar disorder and schizophrenia; LUSC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg09035930 chr12:129282057 SLC15A4 0.66 13.35 0.59 7.04e-33 Systemic lupus erythematosus; LUSC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.51 0.59 1.72e-33 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.64 7.97 0.4 2.5e-14 Lung function (FEV1/FVC); LUSC trans rs10435719 0.638 rs67146188 chr8:11782433 A/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.76 -0.35 6.16e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7267979 1.000 rs2474777 chr20:25272633 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 19.83 0.74 2.17e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg15017067 chr4:17643749 FAM184B 0.34 5.75 0.3 2e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2969070 1.000 rs917079 chr7:2514181 C/T cg03277898 chr7:2518824 NA -0.26 -5.65 -0.3 3.39e-8 Diastolic blood pressure; LUSC cis rs78579285 0.545 rs79311053 chr16:88785206 C/T cg01900006 chr16:88814613 FAM38A 0.54 6.13 0.32 2.49e-9 Joint mobility (Beighton score); LUSC cis rs61931739 0.534 rs2667447 chr12:34133468 C/A cg06521331 chr12:34319734 NA -0.49 -8.14 -0.41 8e-15 Morning vs. evening chronotype; LUSC cis rs8060686 0.641 rs73612222 chr16:68216072 A/G cg04539111 chr16:67997858 SLC12A4 -0.43 -5.74 -0.3 2.09e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7264396 0.779 rs2425162 chr20:34429974 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.03 -0.44 1.42e-17 Total cholesterol levels; LUSC cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.29 0.49 9.75e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6545883 0.894 rs2177962 chr2:61588070 T/A cg15711740 chr2:61764176 XPO1 0.44 6.69 0.34 9.36e-11 Tuberculosis; LUSC cis rs7615316 0.934 rs6440094 chr3:142316443 C/T cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.61e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg03354898 chr7:1950403 MAD1L1 -0.42 -8.36 -0.42 1.72e-15 Bipolar disorder and schizophrenia; LUSC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs4780401 0.609 rs8047190 chr16:11807097 T/C cg01061890 chr16:11836724 TXNDC11 -0.56 -8.63 -0.43 2.52e-16 Rheumatoid arthritis; LUSC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg16049864 chr8:95962084 TP53INP1 -0.43 -7.21 -0.37 3.66e-12 Type 2 diabetes; LUSC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg05585544 chr11:47624801 NA -0.41 -7.37 -0.37 1.38e-12 Subjective well-being; LUSC cis rs4356932 1.000 rs6814012 chr4:76950778 C/T cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.59e-8 Blood protein levels; LUSC cis rs61612642 0.537 rs6915565 chr6:42192582 G/A cg01092361 chr6:42185687 MRPS10 0.78 8.49 0.42 6.66e-16 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg20203395 chr5:56204925 C5orf35 -0.45 -6.75 -0.35 6.69e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs2979489 0.591 rs62508371 chr8:30422060 C/T cg26383811 chr8:30366931 RBPMS -0.42 -6.65 -0.34 1.18e-10 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs9527 0.569 rs10883801 chr10:104677887 A/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.66 -0.34 1.11e-10 Arsenic metabolism; LUSC cis rs748404 0.697 rs493444 chr15:43566470 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.6 0.43 3.06e-16 Lung cancer; LUSC trans rs9297145 0.724 rs6958790 chr7:98774738 C/T cg07879474 chr5:139064216 NA -0.4 -6.05 -0.31 3.83e-9 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg08027265 chr7:2291960 NA -0.35 -5.67 -0.3 3.08e-8 Schizophrenia; LUSC cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg24642439 chr20:33292090 TP53INP2 0.5 7.46 0.38 7.71e-13 Height; LUSC cis rs7804356 0.906 rs73069541 chr7:26904928 A/G cg03456212 chr7:26904342 SKAP2 -0.58 -6.65 -0.34 1.22e-10 Type 1 diabetes; LUSC cis rs735539 1.000 rs6490605 chr13:21285009 C/T cg04906043 chr13:21280425 IL17D -0.45 -8.67 -0.43 1.97e-16 Dental caries; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg22903657 chr4:1355424 KIAA1530 -0.35 -5.96 -0.31 6.32e-9 Obesity-related traits; LUSC cis rs12900413 0.687 rs28513927 chr15:90304471 T/G cg24249390 chr15:90295951 MESP1 -0.39 -6.01 -0.31 4.94e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg05025164 chr4:1340916 KIAA1530 -0.65 -10.15 -0.49 2.91e-21 Obesity-related traits; LUSC cis rs6700896 0.931 rs7531867 chr1:66107546 A/G cg04111102 chr1:66153794 NA -0.33 -7.44 -0.38 8.86e-13 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg23711669 chr6:146136114 FBXO30 0.91 17.88 0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12667521 chr19:29218732 NA 0.61 8.88 0.44 4.2e-17 Methadone dose in opioid dependence; LUSC cis rs16854884 0.586 rs6795008 chr3:143738421 A/G cg06585982 chr3:143692056 C3orf58 0.52 8.29 0.41 2.86e-15 Economic and political preferences (feminism/equality); LUSC cis rs5753618 0.561 rs2073857 chr22:31658281 A/G cg22777020 chr22:31556080 RNF185 -0.45 -5.76 -0.3 1.95e-8 Colorectal cancer; LUSC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg11764359 chr7:65958608 NA 0.68 10.97 0.51 3.99e-24 Aortic root size; LUSC trans rs1814175 0.754 rs10219245 chr11:49645052 C/T cg03929089 chr4:120376271 NA -1.02 -19.42 -0.73 9.06e-57 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00118684 chr18:13726609 RNMT;C18orf19 0.44 5.95 0.31 6.78e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs727505 1.000 rs28622327 chr7:124526213 C/T cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg00684032 chr4:1343700 KIAA1530 0.34 6.1 0.32 2.95e-9 Longevity; LUSC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.83 -10.92 -0.51 6.32e-24 Schizophrenia; LUSC cis rs8017423 0.967 rs11627429 chr14:90689232 G/A cg04374321 chr14:90722782 PSMC1 -0.68 -10.22 -0.49 1.66e-21 Mortality in heart failure; LUSC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs9300255 0.679 rs4759409 chr12:123719585 G/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.88 -0.31 9.74e-9 Neutrophil percentage of white cells; LUSC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg22834771 chr12:69754056 YEATS4 -0.42 -5.76 -0.3 1.96e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg21782813 chr7:2030301 MAD1L1 -0.43 -7.25 -0.37 2.85e-12 Bipolar disorder and schizophrenia; LUSC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg00990874 chr7:1149470 C7orf50 -0.51 -6.39 -0.33 5.43e-10 Bronchopulmonary dysplasia; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg13047869 chr3:10149882 C3orf24 0.65 9.2 0.45 3.94e-18 Alzheimer's disease; LUSC cis rs9326248 1.000 rs7946257 chr11:117053165 A/G cg11861562 chr11:117069780 TAGLN 0.45 8.02 0.4 1.75e-14 Blood protein levels; LUSC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg06671706 chr8:8559999 CLDN23 0.51 6.98 0.36 1.6e-11 Obesity-related traits; LUSC cis rs4243830 0.850 rs12029123 chr1:6607142 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.88 10.36 0.49 5.27e-22 Body mass index; LUSC cis rs1797081 0.542 rs2603796 chr10:16871456 C/T cg23933602 chr10:16859644 RSU1 0.67 11.14 0.52 9.93e-25 Platelet distribution width; LUSC cis rs1784581 0.894 rs1790000 chr6:162388707 A/G cg17173639 chr6:162384350 PARK2 0.84 16.23 0.66 4.22e-44 Itch intensity from mosquito bite; LUSC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg18252515 chr7:66147081 NA 1.23 14.1 0.61 9.75e-36 Diabetic kidney disease; LUSC cis rs5769707 0.604 rs1018814 chr22:50036900 T/C cg20744362 chr22:50050164 C22orf34 0.39 7.29 0.37 2.32e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs950776 0.518 rs11636131 chr15:78821606 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.61 0.69 1.51e-49 Chronic sinus infection; LUSC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg24296786 chr1:45957014 TESK2 0.52 8.13 0.41 8.45e-15 High light scatter reticulocyte count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01252224 chr16:83841660 HSBP1 0.46 6.34 0.33 7.54e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13256369 0.802 rs34762800 chr8:8559294 G/A cg17143192 chr8:8559678 CLDN23 0.64 8.85 0.44 5.04e-17 Obesity-related traits; LUSC trans rs747782 0.582 rs11039571 chr11:48207259 G/A cg03929089 chr4:120376271 NA 0.67 6.3 0.33 9.53e-10 Intraocular pressure; LUSC cis rs7208859 0.573 rs28779471 chr17:29084369 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg20503657 chr10:835505 NA 0.97 13.53 0.6 1.42e-33 Eosinophil percentage of granulocytes; LUSC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.14 16.34 0.67 1.63e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9308433 0.529 rs4655243 chr1:214497291 A/G cg06198575 chr1:214491504 SMYD2 0.45 7.06 0.36 9.75e-12 IgG glycosylation; LUSC cis rs6426558 0.537 rs694740 chr1:227293451 A/G cg10327440 chr1:227177885 CDC42BPA 0.54 7.26 0.37 2.82e-12 Neutrophil percentage of white cells; LUSC cis rs56804039 1.000 rs59620654 chr8:8382632 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -6.66 -0.34 1.11e-10 Cervical cancer; LUSC trans rs11992162 0.613 rs6998690 chr8:11798796 A/T cg27411982 chr8:10470053 RP1L1 0.42 6.33 0.33 7.72e-10 Monocyte count; LUSC cis rs4654899 1.000 rs6426656 chr1:21343245 G/C cg01072550 chr1:21505969 NA -0.55 -8.41 -0.42 1.23e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.48 0.53 5.96e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.71 12.0 0.55 7.98e-28 Prudent dietary pattern; LUSC cis rs3859192 0.599 rs12451897 chr17:38179275 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.98 0.58 1.85e-31 White blood cell count; LUSC cis rs4132509 0.895 rs7556516 chr1:243782009 G/A cg21452805 chr1:244014465 NA 0.49 5.65 0.3 3.37e-8 RR interval (heart rate); LUSC cis rs35306767 0.633 rs17221491 chr10:1065191 A/G cg20503657 chr10:835505 NA 0.7 8.52 0.42 5.57e-16 Eosinophil percentage of granulocytes; LUSC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg27432699 chr2:27873401 GPN1 -0.63 -9.66 -0.47 1.2e-19 Total body bone mineral density; LUSC trans rs28647808 0.881 rs71483208 chr9:136258824 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs9329221 0.905 rs4433149 chr8:10249268 A/T cg21775007 chr8:11205619 TDH -0.56 -8.31 -0.41 2.46e-15 Neuroticism; LUSC cis rs7202877 0.706 rs4993971 chr16:75411634 C/G cg03315344 chr16:75512273 CHST6 -0.41 -6.22 -0.32 1.5e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg11645453 chr3:52864694 ITIH4 0.35 8.38 0.42 1.53e-15 Bipolar disorder; LUSC cis rs4930561 0.714 rs7126326 chr11:67947275 T/G cg04465784 chr11:67976953 SUV420H1 -0.28 -5.67 -0.3 3.05e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs1018836 0.663 rs2205151 chr8:91483468 A/C cg16814680 chr8:91681699 NA -0.65 -9.85 -0.47 2.9e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18758796 chr5:131593413 PDLIM4 0.53 9.17 0.45 4.88e-18 Acylcarnitine levels; LUSC trans rs561341 0.714 rs474455 chr17:30312465 A/T cg27661571 chr11:113659931 NA -0.6 -7.25 -0.37 2.83e-12 Hip circumference adjusted for BMI; LUSC cis rs12421382 0.507 rs2186673 chr11:109285519 G/A cg16359550 chr11:109292809 C11orf87 0.44 7.06 0.36 9.47e-12 Schizophrenia; LUSC cis rs950169 0.580 rs4603535 chr15:85173872 C/T cg11189052 chr15:85197271 WDR73 0.5 6.26 0.32 1.17e-9 Schizophrenia; LUSC cis rs6537837 1.000 rs11810577 chr1:110138109 C/T cg05049280 chr1:110155535 GNAT2 0.47 6.55 0.34 2.15e-10 Major depressive disorder; LUSC cis rs2250402 0.510 rs6492926 chr15:40325829 T/G cg10636054 chr15:40330586 SRP14 0.88 8.33 0.41 2.17e-15 Corneal curvature; LUSC cis rs9581857 0.685 rs9579084 chr13:28028201 A/G cg22138327 chr13:27999177 GTF3A -0.72 -8.57 -0.42 3.95e-16 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg02825527 chr7:2087843 MAD1L1 0.51 5.85 0.3 1.16e-8 Bipolar disorder; LUSC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg13047869 chr3:10149882 C3orf24 0.42 6.44 0.33 4.21e-10 Alzheimer's disease; LUSC cis rs1163251 0.902 rs511059 chr1:120217081 G/T cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC cis rs9297145 0.565 rs7794690 chr7:98764768 G/A cg05967295 chr7:98741636 SMURF1 -0.66 -10.48 -0.5 2.17e-22 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs912057 0.965 rs1294415 chr6:6740633 G/A cg06612196 chr6:6737390 NA 0.55 10.39 0.49 4.32e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs2295359 0.892 rs72676058 chr1:67627681 C/A cg03340356 chr1:67600835 NA 0.43 6.64 0.34 1.28e-10 Psoriasis; LUSC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.55 7.11 0.36 6.89e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -6.99 -0.36 1.55e-11 Major depressive disorder; LUSC cis rs9399401 0.626 rs4304190 chr6:142778912 A/G cg04461802 chr6:142623433 GPR126 0.46 5.9 0.31 8.82e-9 Chronic obstructive pulmonary disease; LUSC cis rs10791323 0.569 rs10791335 chr11:133739571 A/T cg00579200 chr11:133705235 NA -0.41 -6.15 -0.32 2.23e-9 Childhood ear infection; LUSC cis rs4803468 0.901 rs3745292 chr19:41888506 A/G cg09537434 chr19:41945824 ATP5SL -0.88 -15.47 -0.65 4.51e-41 Height; LUSC cis rs12220238 1.000 rs111704178 chr10:75957251 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.22 0.37 3.42e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9486715 0.830 rs2475023 chr6:96996833 G/A cg06623918 chr6:96969491 KIAA0776 -0.95 -17.65 -0.69 1.04e-49 Headache; LUSC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.04 -0.44 1.26e-17 Monocyte percentage of white cells; LUSC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg11764359 chr7:65958608 NA 0.63 9.69 0.47 1.01e-19 Calcium levels; LUSC cis rs4919087 1.000 rs4919087 chr10:99072507 C/T cg25902810 chr10:99078978 FRAT1 -0.49 -7.19 -0.37 4.17e-12 Monocyte count; LUSC cis rs79149102 0.649 rs1531162 chr15:75111984 C/T cg09165964 chr15:75287851 SCAMP5 -0.91 -6.49 -0.33 3.08e-10 Lung cancer; LUSC cis rs611744 0.870 rs429315 chr8:109094068 A/G cg18478394 chr8:109455254 TTC35 -0.39 -5.74 -0.3 2.12e-8 Dupuytren's disease; LUSC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg21251018 chr6:28226885 NKAPL -0.32 -6.17 -0.32 1.97e-9 Cardiac Troponin-T levels; LUSC cis rs6489882 0.867 rs6489870 chr12:113363972 G/A cg20102336 chr12:113376681 OAS3 -0.41 -5.89 -0.31 9.59e-9 Chronic lymphocytic leukemia; LUSC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.8 -11.57 -0.53 2.85e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs16910800 0.731 rs1871953 chr11:23192677 G/A cg20040320 chr11:23191996 NA -0.6 -7.56 -0.38 4.05e-13 Cancer; LUSC cis rs8044995 0.563 rs55968019 chr16:68398111 G/A cg09835421 chr16:68378352 PRMT7 -0.77 -8.57 -0.42 3.86e-16 Schizophrenia; LUSC cis rs9914988 0.943 rs2043031 chr17:27085564 A/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.68 -0.3 3e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs897984 0.537 rs8045637 chr16:30818662 C/T cg00531865 chr16:30841666 NA -0.33 -6.01 -0.31 4.87e-9 Dementia with Lewy bodies; LUSC cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg07148914 chr20:33460835 GGT7 -0.52 -8.11 -0.41 1e-14 Glomerular filtration rate (creatinine); LUSC cis rs7267979 1.000 rs2500443 chr20:25331442 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.18 -0.71 7.93e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg01879757 chr17:41196368 BRCA1 -0.48 -7.29 -0.37 2.23e-12 Menopause (age at onset); LUSC cis rs1160297 0.576 rs1451456 chr2:53092604 A/C cg07782112 chr2:53107842 NA 0.44 7.09 0.36 8.14e-12 Hemostatic factors and hematological phenotypes; LUSC trans rs61931739 0.929 rs1825358 chr12:34011895 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.77 -0.39 1e-13 Morning vs. evening chronotype; LUSC trans rs12579753 0.797 rs1922561 chr12:82152640 C/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.59 -0.34 1.74e-10 Resting heart rate; LUSC cis rs1865760 1.000 rs9393675 chr6:25930116 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 6.87 0.35 3.19e-11 Height; LUSC cis rs8114671 0.967 rs2069945 chr20:33761837 C/G cg24642439 chr20:33292090 TP53INP2 0.45 6.35 0.33 7.14e-10 Height; LUSC cis rs6918586 0.658 rs198822 chr6:26123539 G/C cg17691542 chr6:26056736 HIST1H1C 0.39 5.85 0.3 1.17e-8 Schizophrenia; LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg00149659 chr3:10157352 C3orf10 0.93 13.6 0.6 7.69e-34 Alzheimer's disease; LUSC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg12379764 chr21:47803548 PCNT 0.45 6.24 0.32 1.34e-9 Testicular germ cell tumor; LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg08219700 chr8:58056026 NA 0.64 8.26 0.41 3.49e-15 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.812 rs17214987 chr3:41810481 C/T cg03022575 chr3:42003672 ULK4 -0.79 -8.58 -0.42 3.64e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg11764359 chr7:65958608 NA 0.71 10.66 0.5 5.06e-23 Aortic root size; LUSC cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg08999081 chr20:33150536 PIGU 0.55 11.08 0.52 1.6e-24 Coronary artery disease; LUSC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -7.59 -0.38 3.19e-13 Developmental language disorder (linguistic errors); LUSC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg22532475 chr10:104410764 TRIM8 -0.32 -6.94 -0.36 2.03e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg24642439 chr20:33292090 TP53INP2 0.5 7.43 0.38 8.94e-13 Height; LUSC cis rs35995292 0.534 rs2392604 chr7:38918012 C/T cg19327137 chr7:38886074 VPS41 0.55 10.36 0.49 5.52e-22 Subjective well-being (multi-trait analysis); LUSC trans rs6598955 0.671 rs13374173 chr1:26602256 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.47 -0.42 7.94e-16 Obesity-related traits; LUSC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg03676636 chr4:99064102 C4orf37 0.37 7.91 0.4 3.7e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 0.967 rs7786031 chr7:91649001 T/G cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.08e-8 Breast cancer; LUSC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11644478 chr21:40555479 PSMG1 -0.8 -14.48 -0.62 3.24e-37 Cognitive function; LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs765787 0.530 rs11636395 chr15:45535684 G/C cg25801113 chr15:45476975 SHF 0.35 7.02 0.36 1.23e-11 Uric acid levels; LUSC cis rs2882667 0.964 rs11958050 chr5:138301828 A/G cg04439458 chr5:138467593 SIL1 -0.39 -8.0 -0.4 2.05e-14 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4332037 0.539 rs11764780 chr7:2020904 G/C cg23422044 chr7:1970798 MAD1L1 -0.56 -6.17 -0.32 2.02e-9 Bipolar disorder; LUSC cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg24642439 chr20:33292090 TP53INP2 0.73 11.98 0.55 9.08e-28 Coronary artery disease; LUSC cis rs6696846 0.740 rs12125465 chr1:205074854 C/A cg21643547 chr1:205240462 TMCC2 -0.42 -7.65 -0.39 2.15e-13 Red blood cell count; LUSC cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg04586622 chr2:25135609 ADCY3 0.4 8.27 0.41 3.29e-15 Body mass index; LUSC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg05347473 chr6:146136440 FBXO30 -0.55 -9.5 -0.46 4.19e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.35 0.46 1.28e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.09 -16.92 -0.68 7.95e-47 Gut microbiome composition (summer); LUSC cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg14844989 chr11:31128820 NA 0.36 5.64 0.3 3.56e-8 Red blood cell count; LUSC cis rs698833 0.501 rs35347977 chr2:44506921 C/T cg04920474 chr2:44395004 PPM1B 0.55 9.05 0.44 1.23e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg16586182 chr3:47516702 SCAP 0.51 8.12 0.41 9.02e-15 Colorectal cancer; LUSC cis rs3774749 0.565 rs1005678 chr3:50210289 C/G cg14019146 chr3:50243930 SLC38A3 -0.44 -10.02 -0.48 7.72e-21 Intelligence (multi-trait analysis); LUSC cis rs7589342 0.791 rs4438504 chr2:106461035 A/C cg14210321 chr2:106509881 NCK2 -0.52 -7.64 -0.39 2.35e-13 Addiction; LUSC cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg17063962 chr7:91808500 NA -0.6 -9.44 -0.46 6.87e-19 Breast cancer; LUSC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.36 -5.84 -0.3 1.21e-8 Personality dimensions; LUSC cis rs4561483 0.545 rs9927446 chr16:11957164 A/T cg08843971 chr16:11963173 GSPT1 0.42 6.4 0.33 5.2e-10 Testicular germ cell tumor; LUSC cis rs7267979 1.000 rs6107045 chr20:25441936 G/A cg08601574 chr20:25228251 PYGB 0.43 6.57 0.34 1.94e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4285028 0.747 rs9817818 chr3:121466826 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.86 -0.58 5.27e-31 Multiple sclerosis; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg26354017 chr1:205819088 PM20D1 0.95 19.87 0.74 1.49e-58 Menarche (age at onset); LUSC trans rs208520 0.690 rs12201156 chr6:66720874 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 16.21 0.66 5.29e-44 Exhaled nitric oxide output; LUSC cis rs11155671 0.530 rs6935829 chr6:150217811 C/T cg13206674 chr6:150067644 NUP43 0.44 6.71 0.34 8.28e-11 Testicular germ cell tumor; LUSC cis rs921968 0.643 rs523396 chr2:219338789 T/G cg02176678 chr2:219576539 TTLL4 0.64 11.63 0.54 1.77e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs2224391 0.628 rs2753231 chr6:5248915 C/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.5 -0.34 2.92e-10 Height; LUSC cis rs644799 0.710 rs564480 chr11:95561741 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.82 13.52 0.59 1.58e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg21770322 chr7:97807741 LMTK2 0.4 7.01 0.36 1.31e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs11155671 0.530 rs9371223 chr6:150214806 T/C cg09699651 chr6:150184138 LRP11 0.45 7.08 0.36 8.5e-12 Testicular germ cell tumor; LUSC cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.37 0.49 5.09e-22 Bladder cancer; LUSC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg20933634 chr6:27740509 NA 0.42 5.92 0.31 8.17e-9 Parkinson's disease; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg04141948 chr7:1023156 CYP2W1 0.29 5.87 0.31 1.05e-8 Longevity;Endometriosis; LUSC cis rs1949733 0.656 rs2688224 chr4:8404700 C/G cg11789530 chr4:8429930 ACOX3 0.57 8.88 0.44 4.27e-17 Response to antineoplastic agents; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18516985 chr5:159846223 SLU7 0.44 6.06 0.31 3.72e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg11645453 chr3:52864694 ITIH4 0.33 7.75 0.39 1.11e-13 Bipolar disorder; LUSC cis rs644799 0.672 rs11021307 chr11:95501407 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.07 0.61 1.23e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs7900823 0.529 rs10826438 chr10:28556616 C/T cg06646548 chr10:77152949 NA -0.44 -5.96 -0.31 6.52e-9 Lung cancer; LUSC cis rs709400 0.859 rs942863 chr14:104021268 C/T cg24130564 chr14:104152367 KLC1 -0.51 -7.2 -0.37 4.01e-12 Body mass index; LUSC cis rs113601626 1 rs113601626 chr2:24239189 T/TCCTGGC cg08917208 chr2:24149416 ATAD2B 0.99 10.36 0.49 5.38e-22 Lymphocyte percentage of white cells; LUSC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg22535103 chr8:58192502 C8orf71 -0.69 -7.28 -0.37 2.35e-12 Developmental language disorder (linguistic errors); LUSC cis rs6714710 0.603 rs11680321 chr2:98379267 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.38 0.42 1.51e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6693567 0.545 rs1260385 chr1:150316385 G/A cg15654264 chr1:150340011 RPRD2 0.45 7.33 0.37 1.8e-12 Migraine; LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg08027265 chr7:2291960 NA -0.38 -6.24 -0.32 1.33e-9 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs4423214 1.000 rs2282620 chr11:71183477 C/T cg05163923 chr11:71159392 DHCR7 0.78 11.49 0.53 5.51e-26 Vitamin D levels; LUSC cis rs3018712 0.532 rs2510397 chr11:68419559 A/G cg22747802 chr11:68417633 NA -0.43 -5.81 -0.3 1.48e-8 Total body bone mineral density; LUSC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg04025307 chr7:1156635 C7orf50 0.46 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9815354 0.812 rs73828283 chr3:41835099 T/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs73195822 0.614 rs56259130 chr12:111225650 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.14 0.36 5.98e-12 Itch intensity from mosquito bite; LUSC cis rs12986413 0.619 rs1859954 chr19:2145481 G/T cg09261902 chr19:2140048 AP3D1 -0.37 -7.05 -0.36 1.06e-11 Height; LUSC cis rs2635047 0.811 rs10502880 chr18:44770746 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 6.01 0.31 4.85e-9 Educational attainment; LUSC cis rs9346649 0.967 rs6920748 chr6:168490047 T/G cg02770688 chr6:168491649 NA -0.4 -7.65 -0.39 2.23e-13 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs3812762 0.912 rs10769954 chr11:8783713 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.36 6.08 0.32 3.38e-9 Hypospadias; LUSC cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg18721089 chr20:30220636 NA -0.37 -6.48 -0.33 3.28e-10 Mean corpuscular hemoglobin; LUSC cis rs727505 1.000 rs66665074 chr7:124550526 C/T cg23710748 chr7:124431027 NA -0.42 -7.58 -0.38 3.43e-13 Lewy body disease; LUSC cis rs9300255 0.509 rs641760 chr12:123518866 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.1 0.32 2.87e-9 Neutrophil percentage of white cells; LUSC cis rs9527 1.000 rs4919690 chr10:104616500 C/T cg23093090 chr10:104574429 C10orf26 0.39 6.63 0.34 1.34e-10 Arsenic metabolism; LUSC cis rs9479482 0.967 rs34006533 chr6:150350574 C/A cg25797454 chr6:150327115 RAET1K 0.34 7.8 0.39 8.08e-14 Alopecia areata; LUSC cis rs897984 0.806 rs1458202 chr16:30953202 A/G cg02466173 chr16:30829666 NA -0.57 -11.52 -0.53 4.32e-26 Dementia with Lewy bodies; LUSC trans rs2204008 0.777 rs8189597 chr12:38307739 G/C cg06521331 chr12:34319734 NA 0.41 6.21 0.32 1.55e-9 Bladder cancer; LUSC cis rs12042938 0.935 rs751229 chr1:231768539 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.47 6.9 0.35 2.64e-11 Neuranatomic and neurocognitive phenotypes; LUSC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg24879335 chr3:133465180 TF 0.46 8.02 0.4 1.86e-14 Iron status biomarkers (transferrin levels); LUSC cis rs400736 0.602 rs10864330 chr1:8168564 C/T cg25007680 chr1:8021821 PARK7 -0.44 -6.57 -0.34 1.96e-10 Response to antidepressants and depression; LUSC trans rs7746199 0.736 rs17750424 chr6:27701122 T/C cg01620082 chr3:125678407 NA -0.78 -7.29 -0.37 2.28e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg13390004 chr1:15929781 NA 0.41 6.91 0.35 2.52e-11 Systolic blood pressure; LUSC cis rs1823874 0.581 rs12910401 chr15:100339897 T/C cg16400843 chr15:100339927 C15orf51 0.4 7.38 0.37 1.3e-12 IgG glycosylation; LUSC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs28374715 0.532 rs316604 chr15:41775221 C/T cg18705301 chr15:41695430 NDUFAF1 -1.05 -22.08 -0.77 3.04e-67 Ulcerative colitis; LUSC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg17971929 chr21:40555470 PSMG1 0.77 13.53 0.6 1.44e-33 Cognitive function; LUSC trans rs1005277 0.579 rs1780139 chr10:38503018 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.5 -0.46 4.09e-19 Extrinsic epigenetic age acceleration; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg04025307 chr7:1156635 C7orf50 0.4 6.35 0.33 7.06e-10 Longevity;Endometriosis; LUSC cis rs2230307 0.536 rs11166409 chr1:100641411 T/C cg24955406 chr1:100503596 HIAT1 -0.59 -6.52 -0.34 2.52e-10 Carotid intima media thickness; LUSC cis rs600231 0.665 rs2846861 chr11:65222305 A/G cg17120908 chr11:65337727 SSSCA1 -0.54 -9.54 -0.46 3.19e-19 Bone mineral density; LUSC cis rs7804356 1.000 rs12333525 chr7:26847762 C/T cg03456212 chr7:26904342 SKAP2 -0.56 -6.54 -0.34 2.38e-10 Type 1 diabetes; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg21782813 chr7:2030301 MAD1L1 0.53 9.11 0.45 7.49e-18 Bipolar disorder and schizophrenia; LUSC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg18876405 chr7:65276391 NA 0.6 9.67 0.47 1.14e-19 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12262069 chr3:5028410 NA 0.42 6.11 0.32 2.8e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.37 -0.37 1.36e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg18876405 chr7:65276391 NA 0.55 8.73 0.43 1.2e-16 Aortic root size; LUSC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -7.59 -0.38 3.15e-13 Allergic disease (asthma, hay fever or eczema); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07570075 chr5:159343275 ADRA1B -0.51 -6.41 -0.33 4.96e-10 Bipolar disorder and schizophrenia; LUSC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg19774624 chr17:42201019 HDAC5 -0.82 -13.73 -0.6 2.43e-34 Total body bone mineral density; LUSC cis rs11105298 0.891 rs10777163 chr12:89830720 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.52 -7.1 -0.36 7.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs35362007 0.530 rs11621250 chr14:96011442 C/T cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.58 5.67 0.3 3.09e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2413583 0.591 rs12484030 chr22:39712936 G/A cg17798944 chr22:39715225 SNORD43;RPL3 0.68 6.54 0.34 2.37e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.27 0.59 1.45e-32 Chronic sinus infection; LUSC cis rs17604090 0.938 rs73088374 chr7:29654819 C/A cg19413766 chr7:29689036 LOC646762 -0.58 -6.58 -0.34 1.85e-10 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs8114671 0.562 rs8116657 chr20:33476474 C/G cg07148914 chr20:33460835 GGT7 0.56 8.56 0.42 4.04e-16 Height; LUSC cis rs4663969 0.541 rs11902131 chr2:234594269 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.31 -0.33 8.87e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs9818941 0.824 rs13065628 chr3:157789277 A/G cg08654915 chr3:157813417 NA -0.29 -6.61 -0.34 1.49e-10 Height; LUSC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.75e-10 Crohn's disease; LUSC trans rs4729127 0.708 rs17166230 chr7:94017794 G/C cg22713327 chr12:120703336 PXN 0.57 6.0 0.31 5.17e-9 Intelligence; LUSC cis rs4423214 0.569 rs4944044 chr11:71120213 G/A cg05163923 chr11:71159392 DHCR7 0.55 8.08 0.4 1.2e-14 Vitamin D levels; LUSC cis rs4363385 0.818 rs10788852 chr1:153000491 C/G cg25856811 chr1:152973957 SPRR3 -0.35 -5.68 -0.3 2.94e-8 Inflammatory skin disease; LUSC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg12927641 chr6:109611667 NA 0.44 7.68 0.39 1.82e-13 Reticulocyte fraction of red cells; LUSC cis rs9392556 0.829 rs7757606 chr6:4119704 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.22 -0.32 1.53e-9 Blood metabolite levels; LUSC cis rs870825 0.616 rs7678900 chr4:185635249 A/G cg04058563 chr4:185651563 MLF1IP 0.8 13.2 0.59 2.71e-32 Blood protein levels; LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg02475777 chr4:1388615 CRIPAK 0.46 6.77 0.35 5.88e-11 Obesity-related traits; LUSC cis rs7582720 0.832 rs114139737 chr2:203721733 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6489882 0.867 rs7972033 chr12:113363283 C/T cg20102336 chr12:113376681 OAS3 -0.42 -5.92 -0.31 7.96e-9 Chronic lymphocytic leukemia; LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.94e-10 Menopause (age at onset); LUSC cis rs7927771 0.524 rs7110300 chr11:47848442 T/G cg20307385 chr11:47447363 PSMC3 0.45 6.52 0.34 2.68e-10 Subjective well-being; LUSC cis rs10497399 0.730 rs73974114 chr2:174116812 C/A cg22854985 chr2:174082101 ZAK -0.51 -5.73 -0.3 2.2e-8 Adiponectin levels; LUSC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg08847533 chr14:75593920 NEK9 -0.81 -14.58 -0.62 1.31e-37 Height; LUSC cis rs7681440 0.904 rs10004413 chr4:90769479 T/C cg01966878 chr4:90757139 SNCA -0.34 -5.94 -0.31 7.11e-9 Dementia with Lewy bodies; LUSC cis rs4906332 1.000 rs12889703 chr14:103872951 T/A cg04998671 chr14:104000505 TRMT61A -0.46 -7.03 -0.36 1.16e-11 Coronary artery disease; LUSC cis rs7705502 1.000 rs72812826 chr5:173362726 C/T cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.3e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs12950390 0.893 rs4239166 chr17:45847329 A/G cg06532163 chr17:45867833 NA 0.34 6.22 0.32 1.5e-9 IgG glycosylation; LUSC cis rs782590 0.967 rs4290693 chr2:55799991 C/G cg03859395 chr2:55845619 SMEK2 0.86 15.91 0.66 8.28e-43 Metabolic syndrome; LUSC cis rs2230307 0.656 rs1395332 chr1:100503993 A/C cg24955406 chr1:100503596 HIAT1 0.57 6.15 0.32 2.23e-9 Carotid intima media thickness; LUSC cis rs7819412 0.623 rs7833435 chr8:10801137 A/G cg27411982 chr8:10470053 RP1L1 -0.45 -6.98 -0.36 1.55e-11 Triglycerides; LUSC cis rs10740039 0.810 rs4440977 chr10:62377921 C/G cg18175470 chr10:62150864 ANK3 -0.45 -6.58 -0.34 1.87e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6912958 0.712 rs2307379 chr6:88366771 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -9.35 -0.46 1.28e-18 Monocyte percentage of white cells; LUSC cis rs11642862 1.000 rs11642862 chr16:30785824 A/G cg02466173 chr16:30829666 NA 0.65 7.24 0.37 3.07e-12 Tonsillectomy; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18604876 chr3:5164258 ARL8B 0.41 6.0 0.31 5.16e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11756438 0.572 rs2638551 chr6:118998756 T/C cg21191810 chr6:118973309 C6orf204 0.35 5.91 0.31 8.34e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4664308 1.000 rs17831161 chr2:160909360 A/G cg03641300 chr2:160917029 PLA2R1 -0.67 -11.33 -0.53 2.16e-25 Idiopathic membranous nephropathy; LUSC cis rs4654899 0.931 rs7543140 chr1:21180250 G/A cg01072550 chr1:21505969 NA 0.47 7.06 0.36 9.68e-12 Superior frontal gyrus grey matter volume; LUSC cis rs6500602 0.702 rs4786493 chr16:4500122 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.47 6.35 0.33 6.86e-10 Schizophrenia; LUSC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg18350739 chr11:68623251 NA -0.38 -6.67 -0.34 1.04e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.45 -7.12 -0.36 6.52e-12 Alzheimer's disease (late onset); LUSC cis rs7178572 0.568 rs7167794 chr15:77635875 T/C cg22256960 chr15:77711686 NA -0.5 -8.04 -0.4 1.57e-14 Type 2 diabetes; LUSC cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg16102102 chr5:83017553 HAPLN1 0.84 13.08 0.58 7.2e-32 Prostate cancer; LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.5 0.42 6.19e-16 Prudent dietary pattern; LUSC cis rs6835098 0.924 rs13138282 chr4:174120906 C/T cg08422745 chr4:174089978 GALNT7 0.8 12.77 0.57 1.06e-30 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs4363385 0.667 rs399550 chr1:153049917 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.42e-13 Inflammatory skin disease; LUSC cis rs7954584 0.567 rs11043243 chr12:122356370 G/C cg01765077 chr12:122356316 WDR66 0.54 7.58 0.38 3.5e-13 Mean corpuscular volume; LUSC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg06022373 chr22:39101656 GTPBP1 0.8 12.51 0.56 1.05e-29 Menopause (age at onset); LUSC cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg23093090 chr10:104574429 C10orf26 -0.4 -6.86 -0.35 3.45e-11 Arsenic metabolism; LUSC cis rs939574 1.000 rs2293078 chr2:220100683 C/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.09 8.72 0.43 1.31e-16 Platelet distribution width; LUSC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg08807101 chr21:30365312 RNF160 0.8 15.45 0.65 5.01e-41 Dental caries; LUSC cis rs9303401 0.659 rs8074016 chr17:56840587 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.83 13.21 0.59 2.41e-32 Cognitive test performance; LUSC cis rs6977660 0.714 rs12700077 chr7:19791607 A/G cg05791153 chr7:19748676 TWISTNB -0.75 -8.29 -0.41 2.73e-15 Thyroid stimulating hormone; LUSC trans rs10506458 0.834 rs55966529 chr12:63384114 A/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.14 -14.21 -0.61 3.45e-36 Hemostatic factors and hematological phenotypes; LUSC cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg05347473 chr6:146136440 FBXO30 0.58 10.14 0.49 3.11e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs7799006 0.755 rs12534131 chr7:2294123 C/T cg08027265 chr7:2291960 NA -0.64 -11.76 -0.54 5.74e-27 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7937682 0.924 rs499750 chr11:111513645 T/G cg22437258 chr11:111473054 SIK2 0.51 6.96 0.36 1.86e-11 Primary sclerosing cholangitis; LUSC cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg22508957 chr16:3507546 NAT15 0.44 6.26 0.32 1.18e-9 Body mass index (adult); LUSC cis rs7208859 0.623 rs2035494 chr17:29130393 T/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs151234 0.565 rs9924471 chr16:28591530 G/A cg01378222 chr16:28622494 SULT1A1 -0.56 -8.28 -0.41 3.07e-15 Platelet distribution width; LUSC cis rs189798 0.807 rs330909 chr8:8995387 A/G cg15556689 chr8:8085844 FLJ10661 0.46 6.15 0.32 2.18e-9 Myopia (pathological); LUSC cis rs3806843 0.548 rs246055 chr5:140325662 C/T cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs77106637 0.932 rs7109082 chr11:72707441 A/C cg04827223 chr11:72435913 ARAP1 -0.66 -8.43 -0.42 1.09e-15 Type 2 diabetes; LUSC cis rs2742417 1.000 rs2742452 chr3:45765708 C/T cg18779283 chr3:45636154 LIMD1 -0.33 -5.71 -0.3 2.47e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.36 -0.37 1.48e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13108601 chr6:41748242 FRS3;PRICKLE4 0.44 6.17 0.32 1.96e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg18110333 chr6:292329 DUSP22 -0.72 -11.92 -0.55 1.5e-27 Menopause (age at onset); LUSC cis rs10203711 0.933 rs2334025 chr2:239564114 A/G cg14580085 chr2:239553406 NA -0.39 -6.62 -0.34 1.42e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs2235649 0.753 rs4316755 chr16:1849916 T/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.44 -6.04 -0.31 4.12e-9 Blood metabolite levels; LUSC trans rs9510787 1.000 rs4411364 chr13:24191374 A/C cg20646490 chr19:45971291 FOSB 0.51 6.06 0.31 3.69e-9 Nasopharyngeal carcinoma; LUSC cis rs7809950 0.599 rs2237658 chr7:106837866 T/G cg23024343 chr7:107201750 COG5 -0.49 -7.14 -0.36 5.94e-12 Coronary artery disease; LUSC trans rs4650994 0.525 rs11806608 chr1:178511375 T/C cg05059571 chr16:84539110 KIAA1609 -0.46 -8.67 -0.43 1.87e-16 HDL cholesterol levels;HDL cholesterol; LUSC cis rs9473147 0.543 rs9349407 chr6:47453378 C/G cg12968598 chr6:47444699 CD2AP 0.52 7.96 0.4 2.63e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7572644 0.766 rs34483784 chr2:28129391 G/A cg27432699 chr2:27873401 GPN1 0.52 6.43 0.33 4.31e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6714710 0.603 rs13020776 chr2:98402753 T/A cg26665480 chr2:98280029 ACTR1B 0.58 8.41 0.42 1.17e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs2797160 1.000 rs1739376 chr6:126012084 C/G cg05039488 chr6:79577232 IRAK1BP1 0.44 6.59 0.34 1.74e-10 Endometrial cancer; LUSC cis rs722599 0.683 rs11848876 chr14:75224626 C/G cg08847533 chr14:75593920 NEK9 0.47 6.56 0.34 2e-10 IgG glycosylation; LUSC cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg08213375 chr14:104286397 PPP1R13B 0.53 10.28 0.49 1.01e-21 Schizophrenia; LUSC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg23625390 chr15:77176239 SCAPER -0.51 -7.75 -0.39 1.11e-13 Blood metabolite levels; LUSC cis rs9393777 0.588 rs3799380 chr6:26467182 C/T cg12292205 chr6:26970375 C6orf41 0.6 7.71 0.39 1.48e-13 Intelligence (multi-trait analysis); LUSC cis rs950169 0.845 rs4106951 chr15:84833394 C/G cg17173187 chr15:85201210 NMB 0.37 6.7 0.34 8.96e-11 Schizophrenia; LUSC cis rs1865721 1.000 rs8094181 chr18:73193976 T/A cg26385618 chr18:73139727 C18orf62 -0.48 -8.1 -0.41 1.04e-14 Intelligence; LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg20295408 chr7:1910781 MAD1L1 -0.43 -5.87 -0.31 1.04e-8 Bipolar disorder and schizophrenia; LUSC cis rs737008 0.959 rs11865598 chr16:11403432 T/C cg00044050 chr16:11439710 C16orf75 0.58 8.83 0.44 5.88e-17 Obesity-related traits; LUSC cis rs174479 0.647 rs174454 chr11:61650747 A/G cg01500311 chr11:61656094 FADS3 -0.37 -6.43 -0.33 4.29e-10 Sphingolipid levels; LUSC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg06740227 chr12:86229804 RASSF9 0.4 6.38 0.33 5.89e-10 Major depressive disorder; LUSC cis rs2742234 0.541 rs1879310 chr10:43734775 A/G cg02780029 chr10:43622663 RET 0.34 5.76 0.3 1.88e-8 Hirschsprung disease; LUSC cis rs7312933 0.558 rs4768399 chr12:42742696 G/A cg01256987 chr12:42539512 GXYLT1 0.34 6.19 0.32 1.77e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6599077 0.724 rs13326962 chr3:40087181 C/T cg13683864 chr3:40499215 RPL14 -0.47 -6.61 -0.34 1.48e-10 Sleep-related phenotypes; LUSC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg11645453 chr3:52864694 ITIH4 -0.33 -7.39 -0.37 1.17e-12 Bipolar disorder; LUSC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg23262073 chr20:60523788 NA 0.63 9.03 0.44 1.39e-17 Obesity-related traits; LUSC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.71 0.39 1.44e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3809863 0.602 rs2317677 chr17:45393407 G/A cg25173405 chr17:45401733 C17orf57 -0.46 -6.7 -0.34 8.87e-11 Glaucoma (primary open-angle); LUSC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg22920501 chr2:26401640 FAM59B 0.75 10.05 0.48 6.04e-21 Gut microbiome composition (summer); LUSC cis rs6733011 0.578 rs6714243 chr2:99510039 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.4 -5.67 -0.3 3.09e-8 Bipolar disorder; LUSC cis rs9399135 0.933 rs41294852 chr6:135376379 T/G cg24558204 chr6:135376177 HBS1L 0.58 8.86 0.44 4.81e-17 Red blood cell count; LUSC cis rs4654899 0.802 rs7517642 chr1:21252696 T/C cg01072550 chr1:21505969 NA -0.48 -6.99 -0.36 1.48e-11 Superior frontal gyrus grey matter volume; LUSC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg02034447 chr16:89574710 SPG7 0.46 7.03 0.36 1.19e-11 Multiple myeloma (IgH translocation); LUSC cis rs1034435 0.755 rs6007869 chr22:48894213 A/G cg05992904 chr22:48892994 FAM19A5 -0.41 -8.18 -0.41 6.13e-15 Late-onset Alzheimer's disease; LUSC cis rs977987 0.751 rs56004344 chr16:75474189 T/C cg03315344 chr16:75512273 CHST6 0.49 9.38 0.46 1.03e-18 Dupuytren's disease; LUSC cis rs28489187 0.617 rs11161606 chr1:85853902 T/C cg02862864 chr1:85742044 BCL10 -0.42 -5.79 -0.3 1.62e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC trans rs979233 0.502 rs276254 chr5:42063808 T/C cg07010552 chr17:7358735 CHRNB1 -0.41 -6.02 -0.31 4.72e-9 Systemic lupus erythematosus; LUSC cis rs9517320 0.534 rs4772090 chr13:99150674 T/C cg07423050 chr13:99094983 FARP1 -0.55 -10.68 -0.5 4.25e-23 Longevity; LUSC cis rs7264396 0.635 rs7263302 chr20:34545858 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.83 -0.44 6.04e-17 Total cholesterol levels; LUSC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg27572855 chr1:25598939 RHD -0.46 -8.38 -0.42 1.49e-15 Plateletcrit;Mean corpuscular volume; LUSC cis rs11971779 0.680 rs6954547 chr7:139054734 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC trans rs57221529 0.766 rs72706606 chr5:558609 T/C cg11887960 chr12:57824829 NA 0.55 7.21 0.37 3.7e-12 Lung disease severity in cystic fibrosis; LUSC trans rs2197308 0.765 rs12370231 chr12:37917881 T/C cg06521331 chr12:34319734 NA -0.39 -5.95 -0.31 6.95e-9 Morning vs. evening chronotype; LUSC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg13393036 chr8:95962371 TP53INP1 -0.34 -6.34 -0.33 7.43e-10 Type 2 diabetes; LUSC cis rs72781680 0.752 rs72796138 chr2:23926233 C/T cg08917208 chr2:24149416 ATAD2B 1.0 10.21 0.49 1.77e-21 Lymphocyte counts; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg06873352 chr17:61820015 STRADA 0.71 12.78 0.57 9.99e-31 Prudent dietary pattern; LUSC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.35 -0.42 1.86e-15 Mean platelet volume; LUSC cis rs12911832 1.000 rs12911961 chr15:58985867 C/T cg05156742 chr15:59063176 FAM63B 0.51 7.28 0.37 2.45e-12 Schizophrenia; LUSC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg19912559 chr1:40204330 PPIE 0.5 7.52 0.38 5.17e-13 Blood protein levels; LUSC cis rs12476592 0.602 rs174485 chr2:63857402 G/A cg10828910 chr2:63850056 LOC388955 0.48 5.69 0.3 2.72e-8 Childhood ear infection; LUSC cis rs12586317 0.531 rs57856432 chr14:35719708 G/T cg07166546 chr14:35805898 NA -0.27 -6.22 -0.32 1.45e-9 Psoriasis; LUSC cis rs892961 0.932 rs7224442 chr17:75413439 A/G cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs2762353 0.603 rs9393670 chr6:25789061 A/G cg12310025 chr6:25882481 NA 0.39 6.67 0.34 1.09e-10 Blood metabolite levels; LUSC trans rs11098499 0.820 rs28394116 chr4:120524283 T/G cg25214090 chr10:38739885 LOC399744 0.51 7.82 0.39 7.21e-14 Corneal astigmatism; LUSC cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.18 -0.41 6.1e-15 Axial length; LUSC trans rs35110281 0.774 rs141521 chr21:44963686 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.51 0.46 3.79e-19 Mean corpuscular volume; LUSC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg18876405 chr7:65276391 NA -0.53 -8.4 -0.42 1.28e-15 Aortic root size; LUSC cis rs2219968 0.828 rs60036550 chr8:78911936 G/A cg00738934 chr8:78996279 NA -0.41 -7.37 -0.37 1.35e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9325144 0.556 rs34565156 chr12:39028239 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.91 -0.48 1.84e-20 Morning vs. evening chronotype; LUSC cis rs2050392 0.767 rs2183175 chr10:30699336 A/G cg18806716 chr10:30721971 MAP3K8 0.72 11.56 0.53 3.13e-26 Inflammatory bowel disease; LUSC cis rs8028313 0.731 rs6494678 chr15:67946247 C/T cg05925327 chr15:68127851 NA -0.37 -5.76 -0.3 1.92e-8 Obesity; LUSC trans rs7980799 0.682 rs1580396 chr12:33615841 C/A cg26384229 chr12:38710491 ALG10B -0.58 -8.7 -0.43 1.5e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg14092988 chr3:52407081 DNAH1 0.31 6.18 0.32 1.82e-9 Bipolar disorder; LUSC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.11e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg14552801 chr7:65878734 NA 0.39 6.08 0.32 3.37e-9 Aortic root size; LUSC cis rs3087591 1.000 rs9902427 chr17:29625430 G/A cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.12 -0.41 8.94e-15 Hip circumference; LUSC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs6430585 0.528 rs16832205 chr2:136684632 G/A cg07169764 chr2:136633963 MCM6 1.14 17.51 0.69 3.64e-49 Corneal structure; LUSC cis rs4919694 0.572 rs72846714 chr10:104878454 G/A cg05855489 chr10:104503620 C10orf26 0.54 6.39 0.33 5.67e-10 Arsenic metabolism; LUSC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.19 0.32 1.74e-9 Obesity-related traits; LUSC cis rs4148883 0.675 rs116265877 chr4:100096896 G/A cg12011299 chr4:100065546 ADH4 0.47 7.67 0.39 1.9e-13 Alcohol dependence; LUSC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.53 0.53 4.18e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9325144 0.624 rs7309400 chr12:39150369 G/C cg13010199 chr12:38710504 ALG10B -0.47 -7.25 -0.37 2.94e-12 Morning vs. evening chronotype; LUSC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg27286337 chr10:134555280 INPP5A 0.92 12.19 0.55 1.56e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg17330251 chr7:94953956 PON1 -0.37 -5.99 -0.31 5.57e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13980399 chr14:61447827 SLC38A6;TRMT5 -0.43 -6.45 -0.33 4.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3790645 1.000 rs3790645 chr1:26884864 G/A cg17456097 chr1:26900765 RPS6KA1 0.43 6.24 0.32 1.32e-9 Glucose homeostasis traits; LUSC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.32e-11 Tonsillectomy; LUSC cis rs6582630 0.576 rs2387836 chr12:38560070 A/G cg26384229 chr12:38710491 ALG10B 0.55 8.35 0.42 1.78e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs6674970 0.777 rs11204782 chr1:151118035 C/G cg11822372 chr1:151115635 SEMA6C -0.84 -13.58 -0.6 9.82e-34 Childhood ear infection; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg12419862 chr22:24373484 LOC391322 -0.87 -14.23 -0.61 2.98e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7267979 0.966 rs2261784 chr20:25262396 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.74 0.75 5.35e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg06637938 chr14:75390232 RPS6KL1 -0.5 -8.07 -0.4 1.32e-14 Height; LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.28e-9 Menopause (age at onset); LUSC cis rs36093844 0.904 rs4631905 chr11:85589418 T/C cg25872744 chr11:85566296 CCDC83 -0.42 -6.84 -0.35 3.7e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs4911259 0.552 rs11697394 chr20:31460076 G/A cg09781936 chr22:19749961 TBX1 -0.34 -6.02 -0.31 4.72e-9 Inflammatory bowel disease; LUSC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.73 12.99 0.58 1.65e-31 Personality dimensions; LUSC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg22862634 chr11:62369728 EML3;MTA2 0.59 9.32 0.45 1.64e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9398803 0.865 rs9398805 chr6:126726295 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.27 0.32 1.09e-9 Male-pattern baldness; LUSC cis rs4356932 0.967 rs6532159 chr4:76978124 A/G cg00809888 chr4:76862425 NAAA 0.34 5.69 0.3 2.75e-8 Blood protein levels; LUSC cis rs3764563 0.735 rs62106282 chr19:15727124 T/C cg20725493 chr19:15740067 CYP4F8 -0.66 -6.83 -0.35 3.91e-11 Inflammatory biomarkers; LUSC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg23985595 chr17:80112537 CCDC57 0.31 5.88 0.31 9.82e-9 Life satisfaction; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg01802117 chr1:53393560 SCP2 0.43 6.89 0.35 2.77e-11 Monocyte count; LUSC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg16680214 chr1:154839983 KCNN3 -0.44 -7.75 -0.39 1.11e-13 Prostate cancer; LUSC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.5 -7.59 -0.38 3.24e-13 Personality dimensions; LUSC cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg08999081 chr20:33150536 PIGU -0.39 -7.43 -0.38 9.12e-13 Glomerular filtration rate (creatinine); LUSC trans rs12043259 0.685 rs12407417 chr1:204812698 C/T cg05134015 chr14:36973365 SFTA3 -0.49 -6.01 -0.31 4.77e-9 Addiction; LUSC cis rs9815354 0.812 rs57162396 chr3:41896031 G/A cg03022575 chr3:42003672 ULK4 0.84 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4974559 0.739 rs28444605 chr4:1290281 C/A cg02980000 chr4:1222292 CTBP1 1.02 9.35 0.46 1.28e-18 Systolic blood pressure; LUSC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.64 8.74 0.43 1.15e-16 Multiple sclerosis; LUSC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg17971929 chr21:40555470 PSMG1 0.79 13.58 0.6 9.54e-34 Cognitive function; LUSC cis rs35146811 0.731 rs2257213 chr7:99810113 T/C cg19116668 chr7:99932089 PMS2L1 0.34 5.76 0.3 1.94e-8 Coronary artery disease; LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 16.4 0.67 9.02e-45 Platelet count; LUSC cis rs7267979 1.000 rs2424716 chr20:25423538 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.75 0.73 4.73e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg03060546 chr3:49711283 APEH 0.67 8.03 0.4 1.64e-14 Menarche (age at onset); LUSC cis rs6435862 0.636 rs717548 chr2:215676905 G/A cg04004882 chr2:215674386 BARD1 -0.6 -9.01 -0.44 1.64e-17 Neuroblastoma (high-risk); LUSC cis rs1506636 1.000 rs684548 chr7:123397102 A/T cg03229431 chr7:123269106 ASB15 0.65 10.78 0.51 1.82e-23 Plateletcrit;Platelet count; LUSC cis rs1568889 0.838 rs7933991 chr11:28059761 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.92 0.58 3e-31 Bipolar disorder; LUSC cis rs12711979 0.765 rs6715805 chr2:3821117 T/C cg17052675 chr2:3827356 NA -0.58 -11.38 -0.53 1.42e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg12560992 chr17:57184187 TRIM37 -0.84 -15.34 -0.64 1.38e-40 Intelligence (multi-trait analysis); LUSC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.43 -6.81 -0.35 4.6e-11 Alzheimer's disease (late onset); LUSC cis rs11997175 0.603 rs7386384 chr8:33782471 C/T ch.8.33884649F chr8:33765107 NA 0.41 6.26 0.32 1.21e-9 Body mass index; LUSC trans rs7647973 0.593 rs62262730 chr3:49808274 T/G cg21659725 chr3:3221576 CRBN 0.69 8.15 0.41 7.46e-15 Menarche (age at onset); LUSC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg15448220 chr1:150897856 SETDB1 0.39 5.77 0.3 1.79e-8 Tonsillectomy; LUSC cis rs9473147 0.516 rs9367284 chr6:47516369 A/G cg12968598 chr6:47444699 CD2AP 0.52 7.94 0.4 3.18e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg18302933 chr2:88491318 NA -0.38 -7.45 -0.38 8.02e-13 Response to metformin (IC50); LUSC trans rs9944715 1.000 rs4890320 chr18:43814124 T/C cg01718231 chr17:29326311 RNF135 -0.54 -7.71 -0.39 1.45e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7107174 1.000 rs2511180 chr11:77937255 A/G cg02023728 chr11:77925099 USP35 0.51 7.15 0.36 5.67e-12 Testicular germ cell tumor; LUSC cis rs6545883 0.965 rs12713439 chr2:61752154 G/A cg15711740 chr2:61764176 XPO1 -0.5 -7.94 -0.4 3.05e-14 Tuberculosis; LUSC cis rs9467773 0.550 rs4712987 chr6:26399615 A/C cg05738196 chr6:26577821 NA -0.5 -7.13 -0.36 6.37e-12 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.830 rs35635199 chr7:150063342 C/T cg27494647 chr7:150038898 RARRES2 0.43 6.47 0.33 3.51e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg22823121 chr1:150693482 HORMAD1 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs2204008 0.743 rs2132212 chr12:38039405 G/A cg13010199 chr12:38710504 ALG10B 0.6 9.37 0.46 1.09e-18 Bladder cancer; LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg13628971 chr7:2884303 GNA12 0.47 6.5 0.34 2.89e-10 Height; LUSC cis rs765787 0.530 rs2413776 chr15:45544170 A/G cg15395560 chr15:45543142 SLC28A2 0.34 5.72 0.3 2.38e-8 Uric acid levels; LUSC cis rs1371867 0.641 rs1788209 chr8:101337056 C/T cg06002616 chr8:101225028 SPAG1 -0.41 -6.85 -0.35 3.54e-11 Atrioventricular conduction; LUSC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg10802521 chr3:52805072 NEK4 -0.55 -9.0 -0.44 1.75e-17 Electroencephalogram traits; LUSC trans rs561341 0.941 rs550213 chr17:30317518 C/G cg27661571 chr11:113659931 NA -0.62 -7.41 -0.38 1.05e-12 Hip circumference adjusted for BMI; LUSC cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg07828340 chr4:882639 GAK 1.09 11.48 0.53 5.93e-26 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.836 rs2104083 chr20:33649133 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -5.86 -0.31 1.09e-8 Height; LUSC trans rs11098499 0.863 rs1155576 chr4:120450159 A/C cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.36e-13 Corneal astigmatism; LUSC cis rs929354 0.772 rs1182362 chr7:157019535 A/G cg05182265 chr7:156933206 UBE3C 0.58 9.39 0.46 9.77e-19 Body mass index; LUSC trans rs7937682 0.889 rs11213971 chr11:111529829 A/G cg18187862 chr3:45730750 SACM1L 0.55 7.02 0.36 1.27e-11 Primary sclerosing cholangitis; LUSC cis rs4925386 0.808 rs1760073 chr20:60926106 A/G cg06026331 chr20:60912101 LAMA5 -0.43 -5.77 -0.3 1.78e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs724744 0.772 rs1737236 chr6:22350806 C/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.18 -0.32 1.89e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs9814567 0.896 rs6794258 chr3:134344505 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.97 -0.61 2.98e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg16405210 chr4:1374714 KIAA1530 0.55 8.36 0.42 1.72e-15 Obesity-related traits; LUSC cis rs11122272 0.735 rs2808580 chr1:231509259 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg24812749 chr6:127587940 RNF146 0.7 9.92 0.48 1.75e-20 Breast cancer; LUSC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg03709012 chr19:19516395 GATAD2A 0.83 14.07 0.61 1.24e-35 Tonsillectomy; LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg00684032 chr4:1343700 KIAA1530 0.35 5.99 0.31 5.45e-9 Obesity-related traits; LUSC cis rs7605827 0.897 rs11693457 chr2:15612683 A/C cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs9388451 0.626 rs1739384 chr6:126099246 C/A cg05901451 chr6:126070800 HEY2 -0.77 -13.31 -0.59 1.02e-32 Brugada syndrome; LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs4478137 0.501 rs28477602 chr4:164230477 C/T cg06758707 chr4:164254230 NPY1R -0.5 -6.67 -0.34 1.08e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2742234 0.541 rs10899778 chr10:43718509 G/C cg02780029 chr10:43622663 RET 0.35 5.82 0.3 1.41e-8 Hirschsprung disease; LUSC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg12927641 chr6:109611667 NA -0.37 -6.35 -0.33 6.85e-10 Reticulocyte fraction of red cells; LUSC trans rs28647808 0.786 rs4962136 chr9:136256794 A/G cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg04672769 chr5:140070921 HARS;HARS2 0.53 6.22 0.32 1.46e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs611744 0.647 rs702808 chr8:109252554 T/C cg21045802 chr8:109455806 TTC35 0.43 6.57 0.34 1.92e-10 Dupuytren's disease; LUSC cis rs9329221 0.537 rs1351876 chr8:9984777 A/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.7 -0.3 2.69e-8 Neuroticism; LUSC cis rs1113500 0.933 rs10785833 chr1:108639082 A/G cg06207961 chr1:108661230 NA 0.41 7.61 0.38 2.76e-13 Growth-regulated protein alpha levels; LUSC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg11764359 chr7:65958608 NA 0.52 6.98 0.36 1.61e-11 Aortic root size; LUSC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.87 0.35 3.2e-11 Intelligence (multi-trait analysis); LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg24739457 chr1:205821442 NA 0.36 6.2 0.32 1.63e-9 Menarche (age at onset); LUSC cis rs1348850 0.574 rs2365617 chr2:178421934 C/A cg27490568 chr2:178487706 NA 0.45 6.32 0.33 8.19e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg18681998 chr4:17616180 MED28 0.84 15.64 0.65 9.43e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg19539972 chr4:7069911 GRPEL1 0.69 8.68 0.43 1.76e-16 Monocyte percentage of white cells; LUSC cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg02527881 chr3:46936655 PTH1R 0.4 6.96 0.36 1.78e-11 Colorectal cancer; LUSC cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg17063962 chr7:91808500 NA 0.57 8.66 0.43 2.03e-16 Breast cancer; LUSC cis rs9649213 0.614 rs1006169 chr7:97938443 A/G cg09267113 chr7:98030324 BAIAP2L1 0.72 10.24 0.49 1.4e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs7568458 0.591 rs55971080 chr2:85812746 T/C cg23752985 chr2:85803571 VAMP8 0.32 6.7 0.34 9.08e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg08975724 chr8:8085496 FLJ10661 0.49 7.31 0.37 2.02e-12 Myopia (pathological); LUSC cis rs61931739 0.500 rs56056630 chr12:34543465 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs2109514 0.967 rs55883210 chr7:116160524 G/A cg12739419 chr7:116140593 CAV2 -0.28 -6.24 -0.32 1.31e-9 Prevalent atrial fibrillation; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg21782813 chr7:2030301 MAD1L1 0.49 8.48 0.42 7.26e-16 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg09877947 chr5:131593287 PDLIM4 0.59 10.0 0.48 8.91e-21 Acylcarnitine levels; LUSC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.07 -0.32 3.43e-9 Major depressive disorder; LUSC cis rs644799 0.710 rs522536 chr11:95528714 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.51 0.59 1.77e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg09904177 chr6:26538194 HMGN4 -0.75 -6.61 -0.34 1.51e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs11098499 0.954 rs2892848 chr4:120381341 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.46 0.33 3.67e-10 Corneal astigmatism; LUSC cis rs7829975 0.626 rs332040 chr8:8730488 G/A cg15556689 chr8:8085844 FLJ10661 0.7 11.15 0.52 9.54e-25 Mood instability; LUSC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.72e-8 Lung cancer; LUSC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg00310523 chr12:86230176 RASSF9 0.52 9.82 0.47 3.74e-20 Major depressive disorder; LUSC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg19418458 chr7:158789849 NA -0.5 -8.14 -0.41 8.12e-15 Facial morphology (factor 20); LUSC cis rs4919694 1.000 rs7083328 chr10:104769268 G/A cg23093090 chr10:104574429 C10orf26 -0.47 -5.76 -0.3 1.93e-8 Arsenic metabolism; LUSC cis rs478304 0.651 rs11532071 chr11:65500198 C/A cg27068330 chr11:65405492 SIPA1 -0.77 -11.03 -0.52 2.43e-24 Acne (severe); LUSC cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.19e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg02951883 chr7:2050386 MAD1L1 0.45 7.75 0.39 1.11e-13 Bipolar disorder and schizophrenia; LUSC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg26513180 chr16:89883248 FANCA 0.79 6.37 0.33 6.26e-10 Skin colour saturation; LUSC cis rs859767 0.741 rs6759065 chr2:135389197 A/G cg12500956 chr2:135428796 TMEM163 -0.28 -6.37 -0.33 6.39e-10 Neuroticism; LUSC cis rs734999 0.588 rs745367 chr1:2524457 T/C cg18854424 chr1:2615690 NA 0.51 10.34 0.49 6.36e-22 Ulcerative colitis; LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 6.35 0.33 7.14e-10 Electroencephalogram traits; LUSC cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.81 -0.35 4.48e-11 Monocyte percentage of white cells; LUSC cis rs28647808 0.881 rs7029256 chr9:136263655 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg08677398 chr8:58056175 NA 0.52 6.07 0.32 3.47e-9 Developmental language disorder (linguistic errors); LUSC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg00129232 chr17:37814104 STARD3 -0.48 -7.2 -0.37 3.94e-12 Asthma; LUSC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.64 -9.04 -0.44 1.3e-17 Schizophrenia; LUSC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg02082929 chr2:109068933 GCC2 0.41 8.68 0.43 1.82e-16 Mean platelet volume; LUSC cis rs72772090 1.000 rs72772092 chr5:96046912 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -6.91 -0.35 2.5e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg02527881 chr3:46936655 PTH1R 0.39 6.85 0.35 3.57e-11 Colorectal cancer; LUSC cis rs2652834 0.904 rs2729827 chr15:63360564 C/T cg05507819 chr15:63340323 TPM1 0.67 8.89 0.44 3.9e-17 HDL cholesterol; LUSC trans rs2832191 0.716 rs7509628 chr21:30454252 C/T cg14791747 chr16:20752902 THUMPD1 -0.4 -6.16 -0.32 2.09e-9 Dental caries; LUSC cis rs17401966 0.931 rs12131441 chr1:10428952 G/A cg19773385 chr1:10388646 KIF1B -0.57 -9.86 -0.47 2.77e-20 Hepatocellular carcinoma; LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg20295408 chr7:1910781 MAD1L1 -0.48 -6.83 -0.35 4.05e-11 Bipolar disorder and schizophrenia; LUSC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg09509183 chr1:209979624 IRF6 0.44 5.88 0.31 1e-8 Cleft lip with or without cleft palate; LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg22920501 chr2:26401640 FAM59B 0.84 12.37 0.56 3.46e-29 Gut microbiome composition (summer); LUSC cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg03264133 chr6:25882463 NA -0.5 -9.15 -0.45 5.74e-18 Blood metabolite levels; LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg18758796 chr5:131593413 PDLIM4 0.4 7.06 0.36 9.82e-12 Blood metabolite levels; LUSC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg06481639 chr22:41940642 POLR3H -0.5 -5.71 -0.3 2.56e-8 Vitiligo; LUSC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05787193 chr1:84543369 PRKACB 0.41 5.98 0.31 5.87e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs3857536 0.776 rs6941904 chr6:66931042 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs2932538 0.922 rs12136781 chr1:113090655 C/T cg22162597 chr1:113214053 CAPZA1 0.7 10.11 0.48 3.74e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs10432489 0.708 rs12328545 chr2:181771545 T/A cg07312954 chr1:153914453 DENND4B -0.83 -6.07 -0.32 3.54e-9 QT interval; LUSC cis rs2040771 0.804 rs1340958 chr22:19253332 A/G cg02655711 chr22:19163373 SLC25A1 -0.48 -8.58 -0.42 3.64e-16 Metabolite levels (small molecules and protein measures); LUSC trans rs72674100 1.000 rs28368230 chr4:97970611 G/A cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01295842 chr19:16683254 SLC35E1 -0.39 -5.96 -0.31 6.44e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg23583168 chr7:148888333 NA -0.92 -17.33 -0.69 1.88e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg20406979 chr6:167373233 NA 0.26 6.11 0.32 2.77e-9 Crohn's disease; LUSC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg06454157 chr6:167490870 NA -0.25 -6.11 -0.32 2.75e-9 Crohn's disease; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg00814883 chr7:100076585 TSC22D4 -0.76 -9.74 -0.47 6.61e-20 Platelet count; LUSC cis rs3812831 0.695 rs7983872 chr13:114944781 T/G cg15896084 chr13:114927664 NA 0.39 7.02 0.36 1.28e-11 Schizophrenia; LUSC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.37 -0.37 1.34e-12 Electroencephalogram traits; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg09033563 chr22:24373618 LOC391322 -0.48 -6.79 -0.35 5.24e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs8077889 0.672 rs4793028 chr17:41857212 T/C cg26893861 chr17:41843967 DUSP3 1.11 23.99 0.8 1.25e-74 Triglycerides; LUSC cis rs644148 0.836 rs2571111 chr19:45000581 C/A cg15540054 chr19:45004280 ZNF180 -0.64 -9.41 -0.46 8.26e-19 Personality dimensions; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg16743811 chr6:3752421 C6orf145 0.39 6.13 0.32 2.44e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.04 0.58 1.03e-31 Platelet count; LUSC cis rs7264396 0.836 rs6058275 chr20:34186331 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -8.05 -0.4 1.48e-14 Total cholesterol levels; LUSC cis rs1419980 0.673 rs7296837 chr12:7757832 A/G cg25828445 chr12:7781288 NA 0.61 6.46 0.33 3.65e-10 HDL cholesterol levels; LUSC cis rs9291683 0.588 rs13121211 chr4:9999539 A/G cg00071950 chr4:10020882 SLC2A9 0.64 10.69 0.51 3.8e-23 Bone mineral density; LUSC cis rs524281 0.692 rs10791845 chr11:65834340 C/G cg16950941 chr11:66035639 RAB1B 0.47 5.64 0.3 3.55e-8 Electroencephalogram traits; LUSC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.73 -10.49 -0.5 1.86e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10911251 0.546 rs2147578 chr1:183107699 G/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC cis rs354225 0.554 rs4374410 chr2:54819088 G/T cg01766943 chr2:54829624 SPTBN1 0.48 7.78 0.39 9.33e-14 Schizophrenia; LUSC cis rs7903847 0.642 rs7078004 chr10:99140511 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.09 -0.4 1.12e-14 Granulocyte percentage of myeloid white cells; LUSC trans rs11098499 0.954 rs12507964 chr4:120413061 T/A cg25214090 chr10:38739885 LOC399744 0.54 8.06 0.4 1.36e-14 Corneal astigmatism; LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg25036284 chr2:26402008 FAM59B 0.77 11.38 0.53 1.46e-25 Gut microbiome composition (summer); LUSC cis rs7246657 0.653 rs4805207 chr19:37673733 G/A cg23950597 chr19:37808831 NA -0.58 -5.88 -0.31 1.01e-8 Coronary artery calcification; LUSC cis rs7100689 0.577 rs9420349 chr10:82031160 T/C cg01528321 chr10:82214614 TSPAN14 0.84 12.86 0.58 5.03e-31 Post bronchodilator FEV1; LUSC trans rs7824557 0.564 rs2572399 chr8:11234520 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.28 -0.32 1.06e-9 Retinal vascular caliber; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg21906728 chr3:138634677 NA -0.46 -6.14 -0.32 2.3e-9 Hepatitis; LUSC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg02807482 chr3:125708958 NA -0.52 -6.4 -0.33 5.2400000000000005e-10 Blood pressure (smoking interaction); LUSC cis rs9650315 0.866 rs13272994 chr8:57183788 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg16447950 chr5:562315 NA -0.57 -6.95 -0.36 1.97e-11 Lung disease severity in cystic fibrosis; LUSC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg12641515 chr19:46296257 DMWD 0.5 7.42 0.38 9.68e-13 Coronary artery disease; LUSC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.37 -6.4 -0.33 5.39e-10 High light scatter reticulocyte count; LUSC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg18350739 chr11:68623251 NA -0.39 -6.78 -0.35 5.47e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs35110281 0.720 rs162376 chr21:44926759 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.63 -10.68 -0.5 4.31e-23 Mean corpuscular volume; LUSC cis rs9467773 1.000 rs12526680 chr6:26550954 A/G cg05738196 chr6:26577821 NA 0.8 14.86 0.63 1.08e-38 Intelligence (multi-trait analysis); LUSC cis rs10186029 0.582 rs2371795 chr2:213994789 C/G cg08319019 chr2:214017104 IKZF2 0.49 7.48 0.38 6.49e-13 Systemic sclerosis; LUSC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.4 -0.33 5.3e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7944584 0.502 rs10769256 chr11:47378396 C/T cg20307385 chr11:47447363 PSMC3 0.89 15.42 0.64 6.82e-41 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg03433033 chr1:76189801 ACADM 0.8 12.36 0.56 3.86e-29 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22625903 chr11:62313283 AHNAK 0.44 5.95 0.31 6.59e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4792901 0.959 rs3826413 chr17:41633645 C/G cg22562494 chr17:41607896 ETV4 0.28 5.66 0.3 3.22e-8 Dupuytren's disease; LUSC cis rs7216064 0.953 rs2086744 chr17:65849275 C/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.32 -0.45 1.62e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg06022373 chr22:39101656 GTPBP1 0.84 13.88 0.6 6.44e-35 Menopause (age at onset); LUSC cis rs2985684 0.846 rs11157693 chr14:50048426 T/C cg04989706 chr14:50066350 PPIL5 -0.46 -6.21 -0.32 1.57e-9 Carotid intima media thickness; LUSC cis rs4423214 1.000 rs2276360 chr11:71169547 C/G cg05163923 chr11:71159392 DHCR7 0.75 11.35 0.53 1.82e-25 Vitamin D levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12107626 chr17:39992626 KLHL10;NT5C3L 0.47 6.58 0.34 1.78e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs7824557 0.545 rs2572450 chr8:11229638 C/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.12 -0.32 2.56e-9 Retinal vascular caliber; LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03352830 chr11:487213 PTDSS2 0.73 8.74 0.43 1.18e-16 Body mass index; LUSC cis rs6690583 0.623 rs1371143 chr1:85455532 C/T cg22153463 chr1:85462885 MCOLN2 0.62 6.2 0.32 1.68e-9 Serum sulfate level; LUSC cis rs501916 0.727 rs12439630 chr15:48035191 C/T cg16110827 chr15:48056943 SEMA6D -0.43 -6.79 -0.35 5.18e-11 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs61612642 0.523 rs59004693 chr6:42157392 G/A cg10382835 chr6:42185730 MRPS10 0.7 7.17 0.37 4.92e-12 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1707322 0.638 rs1416706 chr1:46602844 G/A cg06784218 chr1:46089804 CCDC17 -0.4 -7.19 -0.37 4.22e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1448094 0.845 rs10863123 chr12:86346254 G/A cg00310523 chr12:86230176 RASSF9 0.39 6.95 0.36 1.87e-11 Major depressive disorder; LUSC cis rs2991971 1.000 rs2991970 chr1:46011005 C/T cg15605315 chr1:45957053 TESK2 0.49 7.8 0.39 7.94e-14 High light scatter reticulocyte count; LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs72781680 0.898 rs72788218 chr2:24090435 C/T cg08917208 chr2:24149416 ATAD2B 0.84 9.78 0.47 4.84e-20 Lymphocyte counts; LUSC cis rs3818285 1.000 rs3740138 chr10:111630931 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.62 -0.38 2.58e-13 Superior crus of antihelix expression; LUSC cis rs6542838 0.671 rs6752025 chr2:99505699 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.13 -0.32 2.49e-9 Fear of minor pain; LUSC cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg23788917 chr6:8435910 SLC35B3 0.51 7.48 0.38 6.83e-13 Motion sickness; LUSC cis rs1395 0.744 rs9653564 chr2:27472618 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.46 7.36 0.37 1.47e-12 Blood metabolite levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg02864875 chr20:36662390 KIAA0406;RPRD1B -0.48 -6.24 -0.32 1.32e-9 Hepatitis; LUSC cis rs981844 0.796 rs11099904 chr4:154681861 A/G cg14289246 chr4:154710475 SFRP2 0.52 7.14 0.36 5.7e-12 Response to statins (LDL cholesterol change); LUSC cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg26647111 chr11:31128758 NA -0.42 -6.12 -0.32 2.69e-9 Red blood cell count; LUSC cis rs11190604 1.000 rs4919469 chr10:102298855 C/A cg23241863 chr10:102295624 HIF1AN 0.48 5.91 0.31 8.26e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs870825 0.790 rs12513128 chr4:185576729 G/C cg04058563 chr4:185651563 MLF1IP 0.83 11.33 0.53 2.12e-25 Blood protein levels; LUSC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg18190219 chr22:46762943 CELSR1 0.42 5.7 0.3 2.63e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs1005277 0.579 rs2505248 chr10:38459097 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.65 -0.47 1.31e-19 Extrinsic epigenetic age acceleration; LUSC cis rs9814567 1.000 rs6800862 chr3:134228628 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.32 -0.59 9.43e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.19 -0.41 5.67e-15 Intelligence (multi-trait analysis); LUSC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg17294928 chr15:75287854 SCAMP5 -0.93 -13.5 -0.59 1.92e-33 Blood trace element (Zn levels); LUSC cis rs4919694 1.000 rs17881215 chr10:104629236 G/C cg04362960 chr10:104952993 NT5C2 1.11 12.64 0.57 3.43e-30 Arsenic metabolism; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg13560548 chr3:10150139 C3orf24 0.49 6.91 0.35 2.43e-11 Alzheimer's disease; LUSC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.57 7.34 0.37 1.68e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs2832191 0.791 rs2251517 chr21:30531951 T/G cg08807101 chr21:30365312 RNF160 0.74 13.26 0.59 1.55e-32 Dental caries; LUSC cis rs12928939 0.517 rs12149325 chr16:71968147 G/C cg03805757 chr16:71968109 PKD1L3 -0.64 -9.8 -0.47 4.31e-20 Post bronchodilator FEV1; LUSC cis rs9487051 1.000 rs6568571 chr6:109613252 A/T cg12927641 chr6:109611667 NA -0.35 -5.86 -0.31 1.13e-8 Reticulocyte fraction of red cells; LUSC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg06112835 chr11:68658793 MRPL21 0.49 7.65 0.39 2.19e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.82 -0.47 3.69e-20 Chronic sinus infection; LUSC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg12963246 chr6:28129442 ZNF389 0.52 7.17 0.37 4.94e-12 Depression; LUSC trans rs1997103 0.954 rs6953004 chr7:55411919 G/A cg20935933 chr6:143382018 AIG1 0.51 7.43 0.38 8.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs11785693 0.819 rs6994891 chr8:4989856 T/A cg26367366 chr8:4980734 NA 0.8 9.32 0.45 1.65e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg07606381 chr6:8435919 SLC35B3 -0.71 -11.8 -0.54 4.33e-27 Motion sickness; LUSC cis rs4751006 0.543 rs9794336 chr10:128777873 C/T cg05702161 chr10:128779687 DOCK1 0.5 5.78 0.3 1.72e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs12413816 0.784 rs35537139 chr10:13768894 G/A cg16485048 chr10:13749193 FRMD4A 0.45 7.51 0.38 5.54e-13 Red cell distribution width; LUSC cis rs1577917 0.740 rs2842614 chr6:86306069 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.74 -0.39 1.16e-13 Response to antipsychotic treatment; LUSC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg08219700 chr8:58056026 NA 0.47 5.79 0.3 1.61e-8 Developmental language disorder (linguistic errors); LUSC trans rs7824557 0.510 rs1435274 chr8:11235910 G/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.34 -0.33 7.65e-10 Retinal vascular caliber; LUSC cis rs308403 0.600 rs13135445 chr4:123664457 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.82 11.03 0.52 2.39e-24 Blood protein levels; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg14092988 chr3:52407081 DNAH1 -0.31 -6.01 -0.31 4.97e-9 Bipolar disorder; LUSC trans rs61931739 0.500 rs7963282 chr12:34535255 A/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg12615879 chr12:58013172 SLC26A10 -0.31 -6.57 -0.34 1.95e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs929354 1.000 rs1182378 chr7:157048322 T/C cg05182265 chr7:156933206 UBE3C 0.49 7.4 0.38 1.13e-12 Body mass index; LUSC cis rs7917772 0.582 rs3936017 chr10:104354424 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.94 0.51 5.25e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7599312 0.534 rs6735626 chr2:213403972 G/A cg16329650 chr2:213403929 ERBB4 0.86 18.45 0.71 6.91e-53 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7762018 0.514 rs60671539 chr6:170165981 A/G cg06875740 chr19:51307921 C19orf48 -0.52 -7.08 -0.36 8.45e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs8114671 0.967 rs9574 chr20:33764632 C/G cg07148914 chr20:33460835 GGT7 0.46 6.86 0.35 3.3e-11 Height; LUSC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.43 6.72 0.35 7.65e-11 Alzheimer's disease (late onset); LUSC cis rs7945718 0.967 rs12417886 chr11:12811731 A/C cg25843174 chr11:12811716 TEAD1 -0.34 -7.6 -0.38 3.01e-13 Educational attainment (years of education); LUSC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs11039100 0.850 rs12792985 chr11:5833742 A/G cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7107174 0.688 rs10899501 chr11:78131408 C/T cg02023728 chr11:77925099 USP35 0.43 6.55 0.34 2.17e-10 Testicular germ cell tumor; LUSC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -7.03 -0.36 1.14e-11 Mean platelet volume; LUSC cis rs2730245 0.618 rs859781 chr7:158661758 G/A cg14689365 chr7:158441557 NCAPG2 0.52 7.56 0.38 3.97e-13 Height; LUSC cis rs35146811 0.735 rs6948729 chr7:99787372 A/G cg13334819 chr7:99746414 C7orf59 -0.5 -6.73 -0.35 7.41e-11 Coronary artery disease; LUSC cis rs62400317 0.859 rs12205860 chr6:45157323 G/A cg20913747 chr6:44695427 NA -0.48 -7.67 -0.39 1.91e-13 Total body bone mineral density; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.75 0.35 6.62e-11 Platelet count; LUSC trans rs9409565 0.826 rs9409550 chr9:97223294 C/G cg05679027 chr9:99775184 HIATL2 -0.49 -6.94 -0.36 2.05e-11 Colorectal cancer (alcohol consumption interaction); LUSC cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.56 -0.6 1.12e-33 Chronic sinus infection; LUSC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg24154853 chr7:158122151 PTPRN2 -0.42 -8.24 -0.41 3.96e-15 Calcium levels; LUSC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg15704280 chr7:45808275 SEPT13 1.03 17.64 0.69 1.06e-49 Coronary artery disease; LUSC cis rs4595586 0.545 rs12811619 chr12:39392196 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs2742234 1.000 rs1864395 chr10:43655697 G/A cg02780029 chr10:43622663 RET -0.35 -6.78 -0.35 5.34e-11 Hirschsprung disease; LUSC trans rs2832077 0.943 rs2832097 chr21:30173340 A/T cg14791747 chr16:20752902 THUMPD1 -0.73 -10.1 -0.48 4.06e-21 Cognitive test performance; LUSC cis rs6500602 0.702 rs3761680 chr16:4524060 C/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.52 6.93 0.35 2.15e-11 Schizophrenia; LUSC cis rs9549260 0.755 rs4941987 chr13:41195992 T/C cg21288729 chr13:41239152 FOXO1 0.6 9.19 0.45 4.44e-18 Red blood cell count; LUSC cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg01206211 chr2:36825736 FEZ2 0.51 10.81 0.51 1.51e-23 Height; LUSC cis rs41271473 0.898 rs17352535 chr1:228822284 C/G cg10167378 chr1:228756711 NA 0.6 7.15 0.36 5.44e-12 Chronic lymphocytic leukemia; LUSC cis rs11190604 1.000 rs11190587 chr10:102266638 C/T cg07080220 chr10:102295463 HIF1AN 0.68 8.76 0.43 9.71e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3812831 0.669 rs7327370 chr13:114946858 A/G cg08824895 chr13:115047677 UPF3A 0.57 8.85 0.44 5.1e-17 Schizophrenia; LUSC cis rs4969178 0.930 rs7208596 chr17:76396528 C/G cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs11785400 1.000 rs4327844 chr8:143733540 C/T cg10596483 chr8:143751796 JRK -0.57 -9.07 -0.44 1.07e-17 Schizophrenia; LUSC cis rs8018808 0.905 rs7142380 chr14:77931231 T/C cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg13722127 chr7:150037890 RARRES2 0.38 5.64 0.3 3.58e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs4974559 0.947 rs28649968 chr4:1362913 G/A cg02980000 chr4:1222292 CTBP1 0.7 6.35 0.33 7.08e-10 Systolic blood pressure; LUSC cis rs7647973 0.710 rs6446285 chr3:49626306 G/A cg03060546 chr3:49711283 APEH 0.65 6.77 0.35 5.86e-11 Menarche (age at onset); LUSC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg20848291 chr7:100343083 ZAN -0.52 -6.33 -0.33 7.73e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs66887589 0.720 rs2036858 chr4:120249237 A/C cg24375607 chr4:120327624 NA 0.53 8.16 0.41 6.95e-15 Diastolic blood pressure; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg21733973 chr7:65235735 NA 0.4 5.67 0.3 3.1e-8 Calcium levels; LUSC trans rs9951602 1.000 rs9951602 chr18:76657779 C/T cg02800362 chr5:177631904 HNRNPAB 0.97 10.55 0.5 1.17e-22 Obesity-related traits; LUSC cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg03060546 chr3:49711283 APEH -0.64 -9.46 -0.46 5.66e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs1670533 1.000 rs2045069 chr4:1052206 T/C cg16405210 chr4:1374714 KIAA1530 -0.48 -6.0 -0.31 5.02e-9 Recombination rate (females); LUSC cis rs1215050 0.791 rs6838628 chr4:98809574 A/G cg05340658 chr4:99064831 C4orf37 0.43 6.87 0.35 3.2e-11 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg03929089 chr4:120376271 NA -0.96 -15.51 -0.65 3.14e-41 Coronary artery disease; LUSC cis rs1808579 0.935 rs6507720 chr18:21119291 A/G cg14672496 chr18:21087552 C18orf8 0.36 6.13 0.32 2.43e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs9815354 0.812 rs73071328 chr3:41810055 A/C cg03022575 chr3:42003672 ULK4 0.83 8.34 0.41 2.04e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg13114125 chr14:105738426 BRF1 -0.9 -15.75 -0.65 3.61e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg23649088 chr2:200775458 C2orf69 0.55 7.39 0.38 1.15e-12 Schizophrenia; LUSC cis rs9341808 0.667 rs10943698 chr6:80934301 C/T cg08355045 chr6:80787529 NA 0.45 7.63 0.39 2.45e-13 Sitting height ratio; LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg16606324 chr3:10149918 C3orf24 0.55 7.4 0.38 1.11e-12 Alzheimer's disease; LUSC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg12463550 chr7:65579703 CRCP 0.52 7.54 0.38 4.41e-13 Aortic root size; LUSC cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg06064525 chr11:970664 AP2A2 -0.35 -7.0 -0.36 1.44e-11 Alzheimer's disease (late onset); LUSC trans rs804280 0.662 rs11784764 chr8:11610874 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -6.25 -0.32 1.27e-9 Myopia (pathological); LUSC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg15145296 chr3:125709740 NA -0.56 -6.26 -0.32 1.2e-9 Blood pressure (smoking interaction); LUSC trans rs488628 0.839 rs507279 chr3:118146851 T/C cg06621744 chr14:37052470 NKX2-8 -0.29 -6.35 -0.33 6.85e-10 White matter integrity (bipolar disorder risk interaction); LUSC cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg27446573 chr6:127587934 RNF146 0.7 10.87 0.51 9.12e-24 Breast cancer; LUSC cis rs10100465 0.961 rs34660998 chr8:118679746 T/C cg09430518 chr8:118662568 NA 0.31 5.91 0.31 8.48e-9 Leprosy; LUSC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg16339924 chr4:17578868 LAP3 0.59 9.2 0.45 3.85e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs61931739 0.782 rs451940 chr12:34196005 T/C cg06521331 chr12:34319734 NA -0.35 -5.93 -0.31 7.61e-9 Morning vs. evening chronotype; LUSC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg06600287 chr1:53387719 ECHDC2 0.28 5.7 0.3 2.58e-8 Monocyte count; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.79 -0.57 9.23e-31 Platelet count; LUSC cis rs1577917 1.000 rs12661204 chr6:86678586 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.91 -0.35 2.45e-11 Response to antipsychotic treatment; LUSC cis rs9329221 0.736 rs2001337 chr8:10251154 G/A cg21775007 chr8:11205619 TDH 0.44 5.76 0.3 1.94e-8 Neuroticism; LUSC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg20811857 chr17:78079795 GAA -0.31 -5.82 -0.3 1.36e-8 Yeast infection; LUSC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg07937631 chr13:79184529 NA -0.37 -6.37 -0.33 6.12e-10 Large artery stroke; LUSC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 9.01 0.44 1.56e-17 Hip circumference adjusted for BMI; LUSC cis rs6545883 0.929 rs1900572 chr2:61650715 T/G cg15711740 chr2:61764176 XPO1 0.43 6.55 0.34 2.13e-10 Tuberculosis; LUSC cis rs8028313 0.630 rs12900208 chr15:67963058 C/G cg27219399 chr15:67835830 MAP2K5 0.37 5.75 0.3 2.05e-8 Obesity; LUSC cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg18357645 chr12:58087776 OS9 -0.53 -7.84 -0.39 6.03e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs9467773 0.595 rs4320356 chr6:26423560 C/T cg09904177 chr6:26538194 HMGN4 -0.56 -8.54 -0.42 4.88e-16 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg16339924 chr4:17578868 LAP3 0.69 11.25 0.52 4.06e-25 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg06636001 chr8:8085503 FLJ10661 0.68 10.58 0.5 9.08e-23 Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04169263 chr16:1756061 MAPK8IP3 -0.4 -6.0 -0.31 5.15e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg00106254 chr7:1943704 MAD1L1 -0.41 -5.88 -0.31 1e-8 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.89 0.31 9.35e-9 Menopause (age at onset); LUSC cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg18904891 chr8:8559673 CLDN23 0.6 8.08 0.4 1.2e-14 Obesity-related traits; LUSC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Parkinson's disease; LUSC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg07636037 chr3:49044803 WDR6 0.46 6.62 0.34 1.41e-10 Resting heart rate; LUSC cis rs1007190 0.881 rs12941832 chr17:42987482 G/T cg15406952 chr17:42872593 NA 0.57 5.71 0.3 2.54e-8 DNA methylation (variation); LUSC cis rs7607369 0.500 rs6712856 chr2:219658617 A/T cg02176678 chr2:219576539 TTLL4 -0.61 -11.37 -0.53 1.57e-25 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15311382 chr11:1404750 NA 0.41 6.2 0.32 1.7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7621025 0.500 rs16844241 chr3:136635171 A/G cg15507776 chr3:136538369 TMEM22 -0.6 -8.36 -0.42 1.73e-15 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg04362960 chr10:104952993 NT5C2 0.57 8.19 0.41 5.56e-15 Arsenic metabolism; LUSC cis rs5167 0.566 rs2075618 chr19:45495668 G/C cg13119609 chr19:45449297 APOC2 0.34 5.67 0.3 3.01e-8 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg27203200 chr16:67193754 TRADD;FBXL8 -0.42 -6.43 -0.33 4.37e-10 Electrocardiographic conduction measures; LUSC trans rs1998174 0.509 rs10798706 chr1:171820018 C/G cg13482142 chr2:234261155 NA 0.41 5.98 0.31 5.69e-9 Platelet distribution width; LUSC cis rs708547 0.874 rs1315006 chr4:57858193 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 8.81 0.43 7e-17 Response to bleomycin (chromatid breaks); LUSC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg03351412 chr1:154909251 PMVK 0.55 8.83 0.44 5.92e-17 Prostate cancer; LUSC cis rs2354432 1.000 rs6680778 chr1:146747153 T/C cg25205988 chr1:146714368 CHD1L 1.12 16.22 0.66 5.04e-44 Mitochondrial DNA levels; LUSC cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs2019216 0.542 rs12450889 chr17:21889379 A/G cg22648282 chr17:21454238 C17orf51 -0.53 -7.71 -0.39 1.47e-13 Pelvic organ prolapse; LUSC cis rs9393692 1.000 rs3999544 chr6:26285867 C/T cg00631329 chr6:26305371 NA -0.49 -9.55 -0.46 2.97e-19 Educational attainment; LUSC cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.86 0.4 5.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs877282 0.945 rs71491303 chr10:772884 G/T cg22713356 chr15:30763199 NA 1.09 15.15 0.64 7.93e-40 Uric acid levels; LUSC cis rs9638182 0.638 rs6946689 chr7:72977637 T/A cg07452164 chr7:72993570 TBL2 0.45 6.36 0.33 6.67e-10 Triglycerides; LUSC trans rs35110281 0.837 rs12627667 chr21:45071396 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.97 0.48 1.14e-20 Mean corpuscular volume; LUSC cis rs751728 1.000 rs6904991 chr6:33732262 T/G cg25922239 chr6:33757077 LEMD2 0.53 7.83 0.39 6.64e-14 Crohn's disease; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg13560548 chr3:10150139 C3orf24 0.52 7.18 0.37 4.69e-12 Alzheimer's disease; LUSC cis rs4975709 0.609 rs2232373 chr5:1882280 C/G cg15595755 chr5:1867978 NA 0.4 6.29 0.33 9.77e-10 Cardiovascular disease risk factors; LUSC cis rs8099014 0.861 rs4940703 chr18:56115386 A/G cg12907477 chr18:56117327 MIR122 0.45 7.05 0.36 1.01e-11 Platelet count; LUSC cis rs9649213 0.614 rs3801258 chr7:97988428 G/A cg08684580 chr7:98029266 BAIAP2L1 0.38 5.71 0.3 2.48e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs11828289 0.660 rs75816907 chr11:23175126 G/A cg20040320 chr11:23191996 NA -0.58 -6.09 -0.32 3.05e-9 Cancer; LUSC cis rs7677751 0.806 rs6850748 chr4:55099164 T/G cg17187183 chr4:55093834 PDGFRA 0.39 5.82 0.3 1.41e-8 Corneal astigmatism; LUSC cis rs7809950 0.862 rs12112877 chr7:106941324 T/C cg23024343 chr7:107201750 COG5 -0.52 -8.26 -0.41 3.36e-15 Coronary artery disease; LUSC cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg09469691 chr10:81107165 PPIF 0.59 8.91 0.44 3.38e-17 Height; LUSC cis rs57244997 1.000 rs57244997 chr6:162397506 G/A cg17173639 chr6:162384350 PARK2 -0.66 -6.54 -0.34 2.34e-10 Mosquito bite size; LUSC cis rs273573 0.961 rs158582 chr11:30995033 T/C cg14844989 chr11:31128820 NA 0.38 5.95 0.31 6.59e-9 Total body bone mineral density; LUSC cis rs12618769 0.652 rs2276603 chr2:99205962 C/T cg10123293 chr2:99228465 UNC50 -0.49 -7.95 -0.4 2.88e-14 Bipolar disorder; LUSC cis rs2204008 0.805 rs4589389 chr12:37946120 C/A cg26384229 chr12:38710491 ALG10B -0.82 -13.75 -0.6 2.18e-34 Bladder cancer; LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg09877947 chr5:131593287 PDLIM4 0.47 7.33 0.37 1.71e-12 Breast cancer; LUSC trans rs11088226 1.000 rs2833889 chr21:33927768 G/T cg09050820 chr6:167586206 TCP10L2 -0.6 -8.16 -0.41 6.84e-15 Gastritis; LUSC trans rs3733585 0.605 rs7656624 chr4:10121097 T/C cg26043149 chr18:55253948 FECH -0.54 -7.8 -0.39 7.94e-14 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20783262 chr1:68152310 GADD45A 0.46 7.26 0.37 2.7e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs67460515 0.892 rs34771618 chr3:161059795 A/C cg03342759 chr3:160939853 NMD3 -0.52 -7.45 -0.38 8.2e-13 Parkinson's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05388307 chr4:166248715 SC4MOL 0.43 6.3 0.33 9.52e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72781680 0.948 rs72781652 chr2:24213754 G/A cg20701182 chr2:24300061 SF3B14 0.59 6.26 0.32 1.21e-9 Lymphocyte counts; LUSC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.5 0.56 1.12e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6424115 0.708 rs34570472 chr1:24191720 A/G cg10978503 chr1:24200527 CNR2 -0.46 -9.69 -0.47 9.61e-20 Immature fraction of reticulocytes; LUSC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg19230755 chr7:65878503 NA -0.4 -5.77 -0.3 1.79e-8 Aortic root size; LUSC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg16235748 chr6:149772707 ZC3H12D -0.28 -5.8 -0.3 1.5e-8 Dupuytren's disease; LUSC trans rs3806843 1.000 rs3806845 chr5:140180737 C/T cg25815440 chr2:42134162 NA -0.26 -6.02 -0.31 4.51e-9 Depressive symptoms (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12213003 chr6:10747896 TMEM14B -0.42 -6.12 -0.32 2.65e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg00990874 chr7:1149470 C7orf50 -0.53 -6.71 -0.34 8.33e-11 Bronchopulmonary dysplasia; LUSC cis rs2404602 0.967 rs7174096 chr15:77072400 A/G cg23625390 chr15:77176239 SCAPER 0.55 8.65 0.43 2.17e-16 Blood metabolite levels; LUSC cis rs67460515 0.892 rs4856703 chr3:161047720 G/T cg03342759 chr3:160939853 NMD3 -0.52 -7.46 -0.38 7.72e-13 Parkinson's disease; LUSC cis rs2073300 0.609 rs3746733 chr20:23349749 C/T cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg09223439 chr15:65282374 SPG21 0.37 6.39 0.33 5.61e-10 Triglycerides; LUSC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg06640241 chr16:89574553 SPG7 0.93 17.31 0.69 2.35e-48 Multiple myeloma (IgH translocation); LUSC cis rs870825 0.616 rs7682557 chr4:185640773 A/G cg04058563 chr4:185651563 MLF1IP 0.86 13.38 0.59 5.34e-33 Blood protein levels; LUSC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg07936489 chr17:37558343 FBXL20 0.7 9.69 0.47 1.02e-19 Glomerular filtration rate (creatinine); LUSC trans rs7937682 0.847 rs583032 chr11:111432757 C/T cg18187862 chr3:45730750 SACM1L 0.55 6.92 0.35 2.3e-11 Primary sclerosing cholangitis; LUSC cis rs34779708 0.931 rs4934724 chr10:35393669 C/T cg03585969 chr10:35415529 CREM 0.62 9.02 0.44 1.55e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg13010199 chr12:38710504 ALG10B 0.49 7.48 0.38 6.62e-13 Morning vs. evening chronotype; LUSC cis rs7614311 0.681 rs55917937 chr3:63894829 A/C cg22134162 chr3:63841271 THOC7 -0.43 -5.7 -0.3 2.59e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs7267979 1.000 rs2027003 chr20:25350498 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.87 -0.7 1.34e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8038465 0.568 rs62004592 chr15:73878019 A/G cg15420318 chr15:73925796 NPTN 0.56 9.45 0.46 6.15e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs868036 0.718 rs922494 chr15:68120644 T/C cg05925327 chr15:68127851 NA -0.4 -6.32 -0.33 8.42e-10 Restless legs syndrome; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20355062 chr10:3827618 KLF6 -0.41 -6.37 -0.33 6.33e-10 Electrocardiographic conduction measures; LUSC cis rs61931739 0.591 rs1608907 chr12:33945435 A/G cg06521331 chr12:34319734 NA -0.42 -6.86 -0.35 3.29e-11 Morning vs. evening chronotype; LUSC cis rs4730250 0.707 rs257372 chr7:106796977 T/G cg02696742 chr7:106810147 HBP1 -0.64 -9.1 -0.45 8.66e-18 Osteoarthritis; LUSC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC trans rs7824557 0.544 rs1865521 chr8:11231249 T/C cg06636001 chr8:8085503 FLJ10661 0.56 8.34 0.42 1.92e-15 Retinal vascular caliber; LUSC cis rs8062405 1.000 rs62037367 chr16:28874547 C/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg25482853 chr8:67687455 SGK3 1.18 18.42 0.71 8.56e-53 Lung disease severity in cystic fibrosis; LUSC cis rs28830936 1.000 rs2412622 chr15:41960311 A/G cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.3 -0.33 9.57e-10 Diastolic blood pressure; LUSC cis rs7617480 0.648 rs14018 chr3:48784270 G/A cg07636037 chr3:49044803 WDR6 0.89 10.8 0.51 1.56e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs9341808 0.558 rs2322635 chr6:80897210 A/G cg08355045 chr6:80787529 NA 0.48 8.29 0.41 2.72e-15 Sitting height ratio; LUSC cis rs181744922 1 rs181744922 chr3:134974529 T/A cg07149179 chr3:134978680 EPHB1 -0.35 -5.76 -0.3 1.93e-8 Daytime sleep phenotypes; LUSC cis rs6582630 0.516 rs8186746 chr12:38347638 G/T cg26384229 chr12:38710491 ALG10B -0.54 -7.93 -0.4 3.38e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.52 7.62 0.39 2.57e-13 Axial length; LUSC cis rs4499344 0.730 rs12460663 chr19:33098238 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.83 12.47 0.56 1.45e-29 Mean platelet volume; LUSC cis rs34779708 0.733 rs11010146 chr10:35541561 T/A cg03585969 chr10:35415529 CREM 0.55 7.59 0.38 3.21e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg02269571 chr22:50332266 NA -0.59 -8.72 -0.43 1.31e-16 Schizophrenia; LUSC cis rs757278 0.552 rs10441245 chr7:117311066 A/G cg10524701 chr7:117356490 CTTNBP2 0.4 5.75 0.3 1.99e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs367943 1.000 rs348954 chr5:112821716 A/G cg12552261 chr5:112820674 MCC -0.44 -7.11 -0.36 7.19e-12 Type 2 diabetes; LUSC cis rs7267979 0.789 rs4815400 chr20:25292560 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.77 -16.29 -0.67 2.51e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6835098 0.923 rs9997477 chr4:174112543 C/T cg08422745 chr4:174089978 GALNT7 -0.8 -13.05 -0.58 9.68e-32 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs9733 0.744 rs2039590 chr1:150813315 G/A cg13175981 chr1:150552382 MCL1 0.45 6.35 0.33 6.95e-10 Tonsillectomy; LUSC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg04317338 chr11:64019027 PLCB3 0.56 5.91 0.31 8.27e-9 Mean platelet volume; LUSC cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg20283391 chr11:68216788 NA -0.59 -8.3 -0.41 2.64e-15 Total body bone mineral density; LUSC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg25456477 chr12:86230367 RASSF9 0.41 7.26 0.37 2.76e-12 Major depressive disorder; LUSC cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg05347473 chr6:146136440 FBXO30 0.46 7.89 0.4 4.31e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg06022373 chr22:39101656 GTPBP1 0.79 12.22 0.56 1.2e-28 Menopause (age at onset); LUSC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg17948913 chr5:572064 NA 0.38 6.27 0.32 1.09e-9 Obesity-related traits; LUSC cis rs9646954 0.542 rs4149512 chr2:101022886 C/T cg12002119 chr2:101014098 CHST10 0.36 5.93 0.31 7.72e-9 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg18099408 chr3:52552593 STAB1 -0.42 -7.2 -0.37 4.03e-12 Bipolar disorder; LUSC cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg14583973 chr4:3374767 RGS12 0.37 7.79 0.39 8.62e-14 Serum sulfate level; LUSC cis rs2073300 0.609 rs6137907 chr20:23344511 C/T cg09953122 chr20:23471693 CST8 -0.67 -5.72 -0.3 2.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg03146154 chr1:46216737 IPP -0.51 -7.14 -0.36 5.86e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs56176327 0.532 rs9849038 chr3:49771990 A/G cg13072238 chr3:49761600 GMPPB -0.63 -8.19 -0.41 5.63e-15 Intelligence (multi-trait analysis); LUSC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg02503808 chr4:7069936 GRPEL1 -1.06 -12.04 -0.55 5.64e-28 Monocyte percentage of white cells; LUSC cis rs920590 0.643 rs6982084 chr8:19669333 G/A cg03894339 chr8:19674705 INTS10 -0.43 -6.2 -0.32 1.64e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs7829975 0.509 rs7838674 chr8:8797073 A/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.85 -0.35 3.59e-11 Mood instability; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg24503407 chr1:205819492 PM20D1 1.01 22.85 0.78 3.1e-70 Menarche (age at onset); LUSC cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.39 0.49 4.16e-22 Bladder cancer; LUSC cis rs4242434 0.927 rs2272718 chr8:22457388 G/A cg03733263 chr8:22462867 KIAA1967 1.01 18.65 0.71 1.11e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg08470875 chr2:26401718 FAM59B -0.68 -9.29 -0.45 2.07e-18 Gut microbiome composition (summer); LUSC cis rs6012953 1.000 rs6012953 chr20:49123043 A/G cg13958625 chr20:49123093 NA 0.31 6.63 0.34 1.33e-10 Vitiligo; LUSC cis rs1448094 0.842 rs7301280 chr12:86455752 G/T cg02569458 chr12:86230093 RASSF9 -0.36 -5.78 -0.3 1.69e-8 Major depressive disorder; LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs28595532 0.702 rs72670256 chr4:119391043 G/A cg21605333 chr4:119757512 SEC24D 1.02 8.31 0.41 2.46e-15 Cannabis dependence symptom count; LUSC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.48 0.53 5.96e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20318713 chr1:45805724 MUTYH;TOE1 -0.48 -6.11 -0.32 2.74e-9 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC cis rs155346 0.901 rs265179 chr5:139365452 C/G cg01090482 chr5:139365336 NRG2 -0.41 -6.53 -0.34 2.41e-10 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg16797656 chr11:68205561 LRP5 0.42 7.75 0.39 1.09e-13 Total body bone mineral density; LUSC cis rs7296418 0.630 rs28419092 chr12:123812629 G/C cg05973401 chr12:123451056 ABCB9 0.55 8.05 0.4 1.5e-14 Platelet count; LUSC trans rs1874124 0.836 rs7549963 chr1:220988260 C/T cg00338749 chr11:1036677 MUC6 0.4 6.31 0.33 8.8e-10 Cholesterol, total; LUSC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg05472934 chr7:22766657 IL6 0.5 7.69 0.39 1.71e-13 Lung cancer; LUSC cis rs1348850 0.914 rs1374437 chr2:178363423 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.69 0.39 1.65e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11039100 0.850 rs34286221 chr11:5834852 G/T cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs116988415 0.584 rs11622171 chr14:65258644 C/G cg00114569 chr14:65239327 SPTB 0.72 7.48 0.38 6.69e-13 Daytime sleep phenotypes; LUSC cis rs7215564 0.908 rs2316067 chr17:78659720 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC trans rs11098499 0.863 rs10034450 chr4:120455649 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs10876993 0.890 rs1082502 chr12:58035706 C/T cg15848620 chr12:58087721 OS9 -0.52 -7.47 -0.38 7.21e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg13114125 chr14:105738426 BRF1 -0.92 -15.9 -0.66 9.08e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg10978503 chr1:24200527 CNR2 0.47 11.01 0.52 2.83e-24 Immature fraction of reticulocytes; LUSC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg06462663 chr19:18546047 ISYNA1 0.49 8.04 0.4 1.59e-14 Breast cancer; LUSC cis rs2573652 0.755 rs1469830 chr15:100517403 G/T cg09918751 chr15:100517450 ADAMTS17 0.53 10.21 0.49 1.74e-21 Height; LUSC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg15110403 chr19:17392923 ANKLE1 -0.52 -7.17 -0.37 4.89e-12 Systemic lupus erythematosus; LUSC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg06221963 chr1:154839813 KCNN3 -0.49 -10.02 -0.48 7.84e-21 Prostate cancer; LUSC cis rs6542838 0.554 rs4311103 chr2:99538362 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.46 -6.27 -0.32 1.1e-9 Fear of minor pain; LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.29e-12 Platelet count; LUSC cis rs826838 1.000 rs11183160 chr12:38676702 T/C cg26384229 chr12:38710491 ALG10B 0.96 17.78 0.7 3.11e-50 Heart rate; LUSC cis rs477692 0.699 rs578932 chr10:131370724 C/A cg05714579 chr10:131428358 MGMT 0.47 6.56 0.34 2.03e-10 Response to temozolomide; LUSC cis rs2979489 0.891 rs6982511 chr8:30355513 G/T cg26383811 chr8:30366931 RBPMS -0.51 -7.99 -0.4 2.18e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg22800045 chr5:56110881 MAP3K1 -0.42 -5.89 -0.31 9.33e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs1448094 0.872 rs7313373 chr12:86398370 C/G cg18827107 chr12:86230957 RASSF9 -0.38 -5.66 -0.3 3.3e-8 Major depressive disorder; LUSC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg25036284 chr2:26402008 FAM59B -0.68 -9.45 -0.46 6.03e-19 Gut microbiome composition (summer); LUSC cis rs12618769 0.597 rs72819996 chr2:99059983 G/A cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs3813567 0.759 rs12594550 chr15:78959037 C/G cg04896959 chr15:78267971 NA 0.41 6.64 0.34 1.28e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.85 0.39 5.81e-14 Electroencephalogram traits; LUSC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg18131467 chr2:239335373 ASB1 1.05 25.16 0.81 4.26e-79 Multiple system atrophy; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.35 0.33 6.89e-10 Bipolar disorder; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg03609292 chr17:4799832 MINK1 -0.42 -6.96 -0.36 1.78e-11 N-glycan levels; LUSC cis rs3740540 0.530 rs10751598 chr10:126290951 A/G cg04949429 chr10:126290192 LHPP -0.35 -7.39 -0.37 1.23e-12 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC trans rs9291683 0.595 rs10939665 chr4:10037628 T/C cg26043149 chr18:55253948 FECH 0.5 7.39 0.37 1.22e-12 Bone mineral density; LUSC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg17173187 chr15:85201210 NMB 0.37 6.61 0.34 1.55e-10 Schizophrenia; LUSC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14240646 chr10:27532245 ACBD5 0.7 8.12 0.41 9.18e-15 Breast cancer; LUSC cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -14.28 -0.62 1.95e-36 Chronic sinus infection; LUSC cis rs9473147 0.516 rs2151975 chr6:47515663 T/C cg20196966 chr6:47445060 CD2AP 0.41 5.8 0.3 1.57e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs765787 0.530 rs12906537 chr15:45520061 T/C cg24006582 chr15:45444508 DUOX1 0.67 9.69 0.47 1.01e-19 Uric acid levels; LUSC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg18512352 chr11:47633146 NA -0.42 -8.77 -0.43 8.98e-17 Subjective well-being; LUSC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg13683864 chr3:40499215 RPL14 -0.97 -16.23 -0.66 4.38e-44 Renal cell carcinoma; LUSC cis rs9329221 0.905 rs17765901 chr8:10249480 G/T cg27411982 chr8:10470053 RP1L1 -0.5 -8.09 -0.4 1.11e-14 Neuroticism; LUSC cis rs4629180 0.586 rs2048252 chr2:102138384 C/T cg04415270 chr2:102091202 RFX8 -0.42 -7.2 -0.37 3.9e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs9837602 1.000 rs62285461 chr3:99767642 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.15 0.32 2.19e-9 Breast cancer; LUSC cis rs17270561 0.609 rs9358878 chr6:25740273 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.86 0.44 4.97e-17 Iron status biomarkers; LUSC cis rs9303401 0.527 rs7224468 chr17:56749943 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.17 0.58 3.55e-32 Cognitive test performance; LUSC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.88 0.4 4.75e-14 Major depressive disorder; LUSC cis rs3736594 0.513 rs62138971 chr2:27840754 G/A cg27432699 chr2:27873401 GPN1 0.64 8.58 0.43 3.6e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2074585 0.517 rs11637971 chr15:91079863 A/C cg10434728 chr15:90938212 IQGAP1 -0.36 -6.85 -0.35 3.64e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs8072100 0.837 rs8070463 chr17:45768836 A/G cg08085267 chr17:45401833 C17orf57 -0.5 -8.07 -0.4 1.25e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg08219700 chr8:58056026 NA 0.51 6.41 0.33 5e-10 Developmental language disorder (linguistic errors); LUSC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg25643088 chr3:52874325 TMEM110 0.39 5.82 0.3 1.4e-8 Schizophrenia; LUSC cis rs9513627 0.920 rs7335315 chr13:100121308 G/A cg25919922 chr13:100150906 NA -0.8 -6.96 -0.36 1.83e-11 Obesity-related traits; LUSC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg07936489 chr17:37558343 FBXL20 -0.7 -9.6 -0.47 1.98e-19 Glomerular filtration rate (creatinine); LUSC cis rs6582630 0.638 rs4882309 chr12:38448595 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.48 -0.33 3.36e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg23788917 chr6:8435910 SLC35B3 0.51 7.48 0.38 6.83e-13 Motion sickness; LUSC cis rs9326248 0.581 rs7120515 chr11:116991926 A/G cg01368799 chr11:117014884 PAFAH1B2 0.59 9.12 0.45 7.15e-18 Blood protein levels; LUSC cis rs4555082 0.915 rs66527719 chr14:105750523 C/G cg27165867 chr14:105738592 BRF1 -0.55 -7.87 -0.4 4.93e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg05585544 chr11:47624801 NA -0.37 -6.45 -0.33 3.82e-10 Subjective well-being; LUSC trans rs4332037 0.506 rs62442924 chr7:1989976 C/T cg10840412 chr1:235813424 GNG4 0.54 7.11 0.36 7.15e-12 Bipolar disorder; LUSC cis rs1372520 0.684 rs2197120 chr4:90729602 A/G cg15133208 chr4:90757351 SNCA -0.55 -8.63 -0.43 2.6e-16 Neuroticism; LUSC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg13798780 chr7:105162888 PUS7 0.56 6.08 0.32 3.26e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9309711 0.772 rs9309714 chr2:3491830 G/C cg10845886 chr2:3471009 TTC15 -0.53 -6.79 -0.35 5.25e-11 Neurofibrillary tangles; LUSC cis rs17125944 0.615 rs2025632 chr14:53294319 T/C cg00686598 chr14:53173677 PSMC6 -0.75 -6.86 -0.35 3.27e-11 Alzheimer's disease (late onset); LUSC trans rs2243480 1.000 rs4718317 chr7:65648901 A/G cg10756647 chr7:56101905 PSPH -0.82 -8.21 -0.41 5.01e-15 Diabetic kidney disease; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg10729496 chr3:10149963 C3orf24 0.55 7.48 0.38 6.53e-13 Alzheimer's disease; LUSC cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.42 -0.38 9.53e-13 Glomerular filtration rate (creatinine); LUSC cis rs10876993 0.928 rs2640629 chr12:58065448 C/T cg15848620 chr12:58087721 OS9 -0.58 -8.48 -0.42 7.58e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg20891283 chr12:69753455 YEATS4 0.94 18.17 0.71 8.64e-52 Cerebrospinal fluid biomarker levels; LUSC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24654547 chr16:68057165 DUS2L;DDX28 0.44 7.54 0.38 4.51e-13 Triglycerides; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12564526 chr7:66767603 PMS2L4;STAG3L4 -0.5 -6.74 -0.35 7.16e-11 Bipolar disorder and schizophrenia; LUSC trans rs853679 0.546 rs200996 chr6:27811828 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -7.75 -0.39 1.1e-13 Depression; LUSC cis rs12422267 0.536 rs11831679 chr12:132609960 C/T cg09764611 chr12:132620959 NA -0.59 -8.71 -0.43 1.41e-16 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs12310956 0.532 rs11052922 chr12:33957476 A/G cg06521331 chr12:34319734 NA -0.45 -7.33 -0.37 1.77e-12 Morning vs. evening chronotype; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg15383120 chr6:291909 DUSP22 -0.66 -11.07 -0.52 1.86e-24 Menopause (age at onset); LUSC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg00033643 chr7:134001901 SLC35B4 0.47 7.27 0.37 2.58e-12 Mean platelet volume; LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg11235426 chr6:292522 DUSP22 -0.46 -6.96 -0.36 1.86e-11 Menopause (age at onset); LUSC cis rs753274 0.650 rs7257738 chr19:14418921 G/C cg25450033 chr19:14444658 NA 0.34 5.82 0.3 1.35e-8 Tumor necrosis factor beta levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13620744 chr19:36478289 NA 0.77 6.69 0.34 9.31e-11 Cognitive performance; LUSC cis rs11105298 0.891 rs12228177 chr12:89862030 G/T cg00757033 chr12:89920650 WDR51B 0.6 10.33 0.49 7.01e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01123282 chr2:157189755 NR4A2 -0.4 -6.06 -0.31 3.73e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12541635 0.966 rs7839195 chr8:107020193 G/A cg10147462 chr8:107024639 NA 0.55 9.84 0.47 3.24e-20 Age of smoking initiation; LUSC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg07701084 chr6:150067640 NUP43 -0.54 -8.2 -0.41 5.21e-15 Lung cancer; LUSC cis rs7584330 0.666 rs72620818 chr2:238354652 G/A cg16989719 chr2:238392110 NA -0.42 -6.68 -0.34 1.02e-10 Prostate cancer; LUSC cis rs13089785 1.000 rs2332682 chr3:123654633 C/T cg02558132 chr3:123411198 MYLK 0.35 6.14 0.32 2.39e-9 Intelligence (multi-trait analysis); LUSC cis rs2439831 1.000 rs2245908 chr15:43731454 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.33 0.41 2.06e-15 Lung cancer in ever smokers; LUSC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg17211192 chr8:82754475 SNX16 0.81 11.11 0.52 1.32e-24 Diastolic blood pressure; LUSC trans rs10432489 0.708 rs4531892 chr2:181746482 T/A cg04744134 chr19:8408128 KANK3 -0.87 -6.65 -0.34 1.19e-10 QT interval; LUSC cis rs9650315 0.538 rs4075154 chr8:57209246 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.69 0.39 1.65e-13 Height; LUSC cis rs10493773 0.609 rs10873716 chr1:86178347 G/T cg17807903 chr1:86174739 ZNHIT6 -0.55 -15.02 -0.63 2.6e-39 Urate levels in overweight individuals; LUSC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.737 rs7595979 chr2:238364492 G/T cg14458575 chr2:238380390 NA 0.67 11.63 0.54 1.77e-26 Prostate cancer; LUSC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg16680214 chr1:154839983 KCNN3 -0.55 -10.51 -0.5 1.68e-22 Prostate cancer; LUSC cis rs7598759 0.966 rs6754426 chr2:232322779 G/A cg19187155 chr2:232395269 NMUR1 0.5 7.48 0.38 6.58e-13 Noise-induced hearing loss; LUSC cis rs955333 0.685 rs6924083 chr6:154899155 G/A cg20019720 chr6:154832845 CNKSR3 0.45 6.35 0.33 6.89e-10 Diabetic kidney disease; LUSC cis rs208520 0.837 rs208488 chr6:66926902 C/T cg07460842 chr6:66804631 NA -1.03 -14.29 -0.62 1.74e-36 Exhaled nitric oxide output; LUSC cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg23711669 chr6:146136114 FBXO30 -0.89 -16.79 -0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs11098499 0.863 rs3775841 chr4:120425777 A/C cg24375607 chr4:120327624 NA 0.75 11.24 0.52 4.35e-25 Corneal astigmatism; LUSC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg00409905 chr10:38381863 ZNF37A -0.36 -6.27 -0.32 1.12e-9 Extrinsic epigenetic age acceleration; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg06873352 chr17:61820015 STRADA 0.7 12.66 0.57 2.96e-30 Prudent dietary pattern; LUSC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg01416388 chr22:39784598 NA -0.45 -7.6 -0.38 3.11e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs1185460 0.967 rs1784459 chr11:118938388 C/A cg01677386 chr11:118938358 VPS11 -0.48 -6.82 -0.35 4.41e-11 Coronary artery disease; LUSC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg22535103 chr8:58192502 C8orf71 -0.67 -7.14 -0.36 5.79e-12 Developmental language disorder (linguistic errors); LUSC cis rs1443512 0.812 rs4759058 chr12:54339052 C/A cg25024717 chr12:54324583 NA -0.38 -6.33 -0.33 7.96e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9479482 0.967 rs61730071 chr6:150342232 G/A cg03788504 chr6:150331562 NA -0.25 -5.72 -0.3 2.34e-8 Alopecia areata; LUSC cis rs34172651 0.917 rs200529 chr16:24758502 T/C cg06028605 chr16:24865363 SLC5A11 -0.47 -8.49 -0.42 6.75e-16 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.836 rs6539935 chr12:86376809 T/C cg18827107 chr12:86230957 RASSF9 -0.38 -5.65 -0.3 3.52e-8 Major depressive disorder; LUSC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg13607699 chr17:42295918 UBTF 0.55 8.37 0.42 1.62e-15 Total body bone mineral density; LUSC cis rs208520 0.507 rs3903670 chr6:66812183 T/C cg07460842 chr6:66804631 NA -1.25 -27.77 -0.84 8.58e-89 Exhaled nitric oxide output; LUSC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11890956 chr21:40555474 PSMG1 0.88 16.21 0.66 5.23e-44 Cognitive function; LUSC cis rs7264396 0.563 rs6060566 chr20:34288226 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.64 -0.43 2.38e-16 Total cholesterol levels; LUSC cis rs11971779 0.680 rs17613690 chr7:139088401 C/T cg23387468 chr7:139079360 LUC7L2 -0.42 -6.28 -0.32 1.05e-9 Diisocyanate-induced asthma; LUSC cis rs561341 0.609 rs9906443 chr17:30185565 C/T cg00745463 chr17:30367425 LRRC37B 0.64 7.67 0.39 1.9e-13 Hip circumference adjusted for BMI; LUSC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.66 -10.08 -0.48 4.86e-21 Hip circumference adjusted for BMI; LUSC cis rs727505 1.000 rs10240673 chr7:124513050 A/G cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs6692729 0.966 rs1150897 chr1:227047249 A/G cg10327440 chr1:227177885 CDC42BPA 0.51 7.28 0.37 2.44e-12 Electrodermal activity; LUSC cis rs778371 0.676 rs13024330 chr2:233715487 A/G cg08000102 chr2:233561755 GIGYF2 0.79 12.42 0.56 2.18e-29 Schizophrenia; LUSC cis rs1355223 1.000 rs1355222 chr11:34758716 C/G cg11058730 chr11:34937778 PDHX;APIP -0.4 -5.64 -0.3 3.54e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.07 -0.44 1.01e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg04539111 chr16:67997858 SLC12A4 -0.46 -6.25 -0.32 1.23e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs11048434 0.736 rs11048190 chr12:9104939 C/T cg23795048 chr12:9217529 LOC144571 0.33 5.76 0.3 1.94e-8 Sjögren's syndrome; LUSC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -9.93 -0.48 1.63e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11098499 0.866 rs7665125 chr4:120402079 G/T cg24375607 chr4:120327624 NA 0.66 10.31 0.49 7.92e-22 Corneal astigmatism; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20060089 chr17:41561319 DHX8 0.42 6.52 0.34 2.65e-10 Triglycerides; LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg19748678 chr4:122722346 EXOSC9 0.74 10.58 0.5 9.68e-23 Type 2 diabetes; LUSC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg09021430 chr5:549028 NA -0.55 -7.37 -0.37 1.35e-12 Obesity-related traits; LUSC cis rs1801251 0.896 rs921054 chr2:233694673 G/A cg25237894 chr2:233734115 C2orf82 -0.34 -6.22 -0.32 1.52e-9 Coronary artery disease; LUSC cis rs7267979 1.000 rs2257809 chr20:25266476 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.54 0.75 3.49e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg19046167 chr17:80928561 B3GNTL1 -0.36 -5.85 -0.31 1.15e-8 Breast cancer; LUSC trans rs75804782 0.641 rs59499060 chr2:239341411 C/T cg01134436 chr17:81009848 B3GNTL1 0.65 6.37 0.33 6.32e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.78e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.38 0.69 1.15e-48 Chronic sinus infection; LUSC trans rs11700980 0.515 rs12481795 chr21:30113730 G/A cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg27398817 chr8:82754497 SNX16 -0.48 -6.43 -0.33 4.53e-10 Diastolic blood pressure; LUSC cis rs1957429 0.731 rs10144554 chr14:65321514 T/G cg23373153 chr14:65346875 NA 0.94 10.5 0.5 1.76e-22 Pediatric areal bone mineral density (radius); LUSC cis rs9467773 1.000 rs2208331 chr6:26507319 A/G cg05738196 chr6:26577821 NA 0.81 15.2 0.64 4.95e-40 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.28e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7786808 0.608 rs6978352 chr7:158209802 T/C cg09998033 chr7:158218633 PTPRN2 0.41 6.39 0.33 5.68e-10 Obesity-related traits; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.38 -6.28 -0.32 1.06e-9 Longevity;Endometriosis; LUSC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg00129232 chr17:37814104 STARD3 -0.47 -7.03 -0.36 1.18e-11 Asthma; LUSC trans rs7824557 0.591 rs2736283 chr8:11225910 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.92 -0.35 2.35e-11 Retinal vascular caliber; LUSC cis rs9329221 0.620 rs6601427 chr8:10156025 A/G cg27411982 chr8:10470053 RP1L1 -0.46 -7.76 -0.39 1.05e-13 Neuroticism; LUSC trans rs8073060 0.544 rs225244 chr17:33946581 A/G cg19694781 chr19:47549865 TMEM160 1.13 18.03 0.7 2.99e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs61863818 0.557 rs7895646 chr10:99167436 A/G cg20016023 chr10:99160130 RRP12 -0.23 -5.69 -0.3 2.72e-8 Monocyte percentage of white cells; LUSC cis rs9326248 0.652 rs7128382 chr11:117023487 A/C cg26566898 chr11:117069891 TAGLN 0.4 6.41 0.33 4.83e-10 Blood protein levels; LUSC cis rs7267979 1.000 rs6050598 chr20:25397257 C/G cg08601574 chr20:25228251 PYGB 0.41 6.28 0.32 1.06e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs7772486 0.806 rs4243478 chr6:146284560 A/G cg13319975 chr6:146136371 FBXO30 0.46 7.01 0.36 1.33e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg25817165 chr18:72167213 CNDP2 -0.72 -10.68 -0.5 4.31e-23 Refractive error; LUSC trans rs4689592 0.619 rs3796908 chr4:7061378 G/A cg07817883 chr1:32538562 TMEM39B -0.56 -6.75 -0.35 6.65e-11 Monocyte percentage of white cells; LUSC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.86 -0.39 5.41e-14 Blood metabolite levels; LUSC cis rs10504229 0.516 rs4361758 chr8:57990401 C/T cg22535103 chr8:58192502 C8orf71 -0.49 -6.43 -0.33 4.5e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg24829409 chr8:58192753 C8orf71 -0.62 -8.02 -0.4 1.78e-14 Developmental language disorder (linguistic errors); LUSC trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4561483 0.801 rs154148 chr16:11956478 T/C cg08843971 chr16:11963173 GSPT1 -0.49 -7.39 -0.37 1.22e-12 Testicular germ cell tumor; LUSC cis rs7647973 0.626 rs1996664 chr3:49878395 A/G cg13072238 chr3:49761600 GMPPB 0.69 8.87 0.44 4.43e-17 Menarche (age at onset); LUSC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg11812906 chr14:75593930 NEK9 0.67 11.71 0.54 8.78e-27 Height; LUSC trans rs9467603 1.000 rs6939997 chr6:25821224 C/T cg06606381 chr12:133084897 FBRSL1 -0.61 -6.14 -0.32 2.39e-9 Intelligence (multi-trait analysis); LUSC cis rs7223966 0.960 rs113155878 chr17:61706560 C/A cg05941027 chr17:61774174 LIMD2 0.22 5.72 0.3 2.4e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg19920283 chr7:105172520 RINT1 0.59 6.08 0.32 3.38e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6545883 0.965 rs10186325 chr2:61757721 G/T cg15711740 chr2:61764176 XPO1 -0.49 -7.75 -0.39 1.12e-13 Tuberculosis; LUSC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -12.08 -0.55 3.94e-28 Type 2 diabetes; LUSC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg04871131 chr7:94954202 PON1 -0.38 -6.08 -0.32 3.2e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.45 8.72 0.43 1.35e-16 Monocyte percentage of white cells; LUSC cis rs11785400 0.963 rs4579507 chr8:143733663 C/G cg24634471 chr8:143751801 JRK 0.59 8.99 0.44 1.82e-17 Schizophrenia; LUSC cis rs7223966 1.000 rs2665826 chr17:61944924 A/G cg11494091 chr17:61959527 GH2 0.35 5.78 0.3 1.73e-8 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs7849782 0.905 rs10819973 chr9:104422240 C/T cg22914338 chr19:14376960 NA 0.26 6.36 0.33 6.77e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs2224391 0.534 rs2753228 chr6:5246623 G/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.49 -6.74 -0.35 7e-11 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22409223 chr3:130465572 PIK3R4 -0.44 -6.04 -0.31 4.13e-9 Hepatitis; LUSC cis rs10504073 0.669 rs818559 chr8:50035806 C/T cg00325661 chr8:49890786 NA 0.6 9.75 0.47 6.18e-20 Blood metabolite ratios; LUSC trans rs9886428 1.000 rs9886428 chr8:14113816 G/A cg19037007 chr20:741798 C20orf54 -0.39 -6.11 -0.32 2.77e-9 IgG glycosylation; LUSC cis rs4631830 0.863 rs4486572 chr10:51531805 A/G cg20129853 chr10:51489980 NA -0.34 -6.62 -0.34 1.4e-10 Prostate-specific antigen levels; LUSC cis rs936229 0.626 rs3765066 chr15:75140854 G/A cg10253484 chr15:75165896 SCAMP2 -0.48 -6.69 -0.34 9.15e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs4356932 1.000 rs10014049 chr4:76953532 C/A cg00809888 chr4:76862425 NAAA 0.34 5.71 0.3 2.44e-8 Blood protein levels; LUSC cis rs7107174 0.792 rs12291726 chr11:78088210 A/G cg02023728 chr11:77925099 USP35 0.45 6.57 0.34 1.98e-10 Testicular germ cell tumor; LUSC cis rs4065321 0.609 rs8075668 chr17:38137623 C/T cg17467752 chr17:38218738 THRA -0.53 -7.87 -0.4 4.97e-14 White blood cell count (basophil);White blood cell count; LUSC cis rs11971779 0.793 rs4728464 chr7:139017670 C/T cg07862535 chr7:139043722 LUC7L2 -0.58 -7.07 -0.36 8.94e-12 Diisocyanate-induced asthma; LUSC cis rs7197653 0.519 rs55757091 chr16:68323654 G/A cg05110241 chr16:68378359 PRMT7 -0.64 -7.62 -0.38 2.72e-13 Magnesium levels; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg06873352 chr17:61820015 STRADA 0.72 12.86 0.58 4.99e-31 Prudent dietary pattern; LUSC cis rs7615952 0.673 rs115942855 chr3:125601960 G/A cg05084668 chr3:125655381 ALG1L -0.91 -11.75 -0.54 6.42e-27 Blood pressure (smoking interaction); LUSC cis rs7709377 0.597 rs6594952 chr5:115488032 A/C cg23108291 chr5:115420582 COMMD10 0.41 5.79 0.3 1.59e-8 Metabolite levels (X-11787); LUSC cis rs3768617 0.510 rs10797852 chr1:183101302 C/T ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC cis rs6540559 0.543 rs672819 chr1:210436404 T/A cg22029157 chr1:209979665 IRF6 0.54 6.14 0.32 2.35e-9 Cleft lip with or without cleft palate; LUSC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg04455712 chr21:45112962 RRP1B 0.43 8.14 0.41 7.98e-15 Mean corpuscular volume; LUSC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg12365402 chr11:9010492 NRIP3 -0.49 -9.32 -0.45 1.64e-18 Hemoglobin concentration; LUSC cis rs3770081 1.000 rs17026854 chr2:86280496 T/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.06 -7.07 -0.36 9.17e-12 Facial emotion recognition (sad faces); LUSC cis rs9914988 0.943 rs7217547 chr17:27106872 C/G cg09479241 chr17:27052676 TLCD1 0.41 5.68 0.3 2.93e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs67072384 1.000 rs12289259 chr11:72446731 A/C cg04827223 chr11:72435913 ARAP1 -0.81 -7.68 -0.39 1.72e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9649213 0.614 rs62479858 chr7:97924226 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.7 -9.89 -0.48 2.1e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg14552801 chr7:65878734 NA 0.39 5.98 0.31 5.64e-9 Aortic root size; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg23758822 chr17:41437982 NA 1.05 20.03 0.74 3.41e-59 Menopause (age at onset); LUSC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.65 -0.43 2.14e-16 Neuroticism; LUSC cis rs2078087 0.831 rs10911295 chr1:183245285 C/A cg13843938 chr1:183241246 NMNAT2 0.45 6.09 0.32 3.13e-9 Obesity-related traits; LUSC cis rs1609391 0.543 rs9881139 chr3:136634040 A/G cg15507776 chr3:136538369 TMEM22 0.52 8.61 0.43 2.84e-16 Neuroticism; LUSC cis rs6547741 1.000 rs2384654 chr2:27847364 C/T cg12559939 chr2:27858050 GPN1 0.4 6.3 0.33 9.22e-10 Oral cavity cancer; LUSC cis rs427394 0.743 rs274716 chr5:6722289 T/C cg25011763 chr5:6727354 POLS -0.35 -5.66 -0.3 3.33e-8 Menopause (age at onset); LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.9 -0.31 8.73e-9 Platelet count; LUSC cis rs911555 0.723 rs6575982 chr14:103862681 G/A cg12935359 chr14:103987150 CKB 0.65 10.36 0.49 5.6e-22 Intelligence (multi-trait analysis); LUSC cis rs7586879 1.000 rs11683212 chr2:25120196 T/C cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.48e-10 Body mass index; LUSC trans rs11098499 0.954 rs10005644 chr4:120298477 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg18099408 chr3:52552593 STAB1 -0.4 -6.78 -0.35 5.39e-11 Bipolar disorder; LUSC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg11062466 chr8:58055876 NA 0.65 8.32 0.41 2.24e-15 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg15704280 chr7:45808275 SEPT13 -1.02 -19.49 -0.73 4.84e-57 Height; LUSC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Metabolite levels (small molecules and protein measures); LUSC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC cis rs3850699 0.683 rs67646802 chr10:104303748 C/T cg05855489 chr10:104503620 C10orf26 0.6 8.39 0.42 1.4e-15 Prostate cancer; LUSC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg05313129 chr8:58192883 C8orf71 -0.51 -5.79 -0.3 1.64e-8 Developmental language disorder (linguistic errors); LUSC cis rs1371867 0.846 rs1660316 chr8:101333049 T/C cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03629926 chr19:8438839 ANGPTL4 0.44 6.5 0.34 2.89e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg03395511 chr6:291903 DUSP22 -0.7 -11.7 -0.54 9.52e-27 Menopause (age at onset); LUSC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg22920501 chr2:26401640 FAM59B -0.73 -10.61 -0.5 7.14e-23 Gut microbiome composition (summer); LUSC cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.32 0.53 2.37e-25 Colorectal cancer; LUSC cis rs7089973 0.604 rs17663670 chr10:116596269 A/C cg23260525 chr10:116636907 FAM160B1 -0.44 -9.43 -0.46 7.2e-19 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11585357 0.843 rs12095095 chr1:17625832 C/G cg08277548 chr1:17600880 PADI3 -0.6 -6.53 -0.34 2.39e-10 Hair shape; LUSC cis rs12760731 0.565 rs34593395 chr1:178129488 C/T cg00404053 chr1:178313656 RASAL2 0.68 6.84 0.35 3.78e-11 Obesity-related traits; LUSC trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg15934090 chr1:100435551 SLC35A3 0.48 8.32 0.41 2.2e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg06008330 chr7:65541103 ASL -0.4 -6.28 -0.32 1.05e-9 Aortic root size; LUSC cis rs7829975 0.582 rs6983150 chr8:8792426 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.96 -0.48 1.27e-20 Mood instability; LUSC cis rs9790314 1.000 rs62279921 chr3:161065441 T/C cg03342759 chr3:160939853 NMD3 -0.49 -8.17 -0.41 6.64e-15 Morning vs. evening chronotype; LUSC cis rs7746199 0.736 rs13195636 chr6:27509493 A/C cg26958806 chr6:27640298 NA 0.76 6.31 0.33 8.8e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs4942242 0.602 rs61960076 chr13:44217784 T/C cg19169023 chr15:41853346 TYRO3 -0.58 -8.85 -0.44 5.15e-17 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4363385 0.510 rs61811902 chr1:153053464 A/G cg00922841 chr1:152955080 SPRR1A -0.42 -6.88 -0.35 3.04e-11 Inflammatory skin disease; LUSC cis rs11190604 1.000 rs11190572 chr10:102232879 A/G cg16342193 chr10:102329863 NA -0.35 -6.24 -0.32 1.32e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.53 -7.28 -0.37 2.39e-12 Mean platelet volume; LUSC cis rs11098499 0.789 rs10212719 chr4:120254437 T/C cg09307838 chr4:120376055 NA 0.69 10.49 0.5 1.94e-22 Corneal astigmatism; LUSC trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg03929089 chr4:120376271 NA -0.76 -10.07 -0.48 5.24e-21 Coronary artery disease; LUSC cis rs10193935 0.901 rs10196091 chr2:42541591 T/C cg27598129 chr2:42591480 NA -0.56 -7.79 -0.39 8.61e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7584330 0.666 rs72620819 chr2:238354982 C/T cg16989719 chr2:238392110 NA -0.41 -6.33 -0.33 7.93e-10 Prostate cancer; LUSC trans rs961253 0.556 rs6054135 chr20:6326654 C/T cg21095983 chr6:86352623 SYNCRIP 0.45 6.78 0.35 5.62e-11 Colorectal cancer; LUSC cis rs7107174 1.000 rs2512544 chr11:77986371 A/T cg02023728 chr11:77925099 USP35 0.5 7.27 0.37 2.53e-12 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.44e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs11039798 1.000 rs7123704 chr11:48580535 G/A cg15704280 chr7:45808275 SEPT13 0.73 6.87 0.35 3.11e-11 Axial length; LUSC cis rs7809950 1.000 rs2520265 chr7:107181231 A/G cg23024343 chr7:107201750 COG5 -0.55 -8.55 -0.42 4.56e-16 Coronary artery disease; LUSC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.11 0.41 9.81e-15 Electroencephalogram traits; LUSC cis rs62458065 0.850 rs28677012 chr7:32469811 C/A cg20159608 chr7:32802032 NA -0.63 -7.5 -0.38 5.76e-13 Metabolite levels (HVA/MHPG ratio); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg10174397 chr17:41150394 RPL27 0.41 6.31 0.33 8.68e-10 Mosquito bite size; LUSC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.35 -0.42 1.81e-15 Neuroticism; LUSC trans rs7746199 0.736 rs17749927 chr6:27669976 A/G cg01620082 chr3:125678407 NA -0.77 -6.9 -0.35 2.57e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg13010199 chr12:38710504 ALG10B 0.69 11.39 0.53 1.28e-25 Heart rate; LUSC cis rs13114435 0.723 rs17331744 chr4:183815561 T/C cg00486011 chr4:183851557 NA 0.31 5.75 0.3 2.06e-8 Obesity-related traits; LUSC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg23791538 chr6:167370224 RNASET2 0.41 6.78 0.35 5.51e-11 Crohn's disease; LUSC cis rs10207060 0.500 rs72992164 chr2:240711780 G/A cg20333904 chr2:240724165 NA -0.37 -6.25 -0.32 1.25e-9 Obesity-related traits; LUSC cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.97 0.36 1.7e-11 Rheumatoid arthritis; LUSC cis rs9733 0.621 rs932054 chr1:150539867 C/G cg17724175 chr1:150552817 MCL1 -0.33 -5.73 -0.3 2.29e-8 Tonsillectomy; LUSC cis rs4692589 0.802 rs1480542 chr4:170953614 C/T cg19918862 chr4:170955249 NA 0.32 6.15 0.32 2.22e-9 Anxiety disorder; LUSC trans rs931812 0.691 rs884488 chr8:101898523 C/G cg20993868 chr7:22813445 NA 0.53 9.76 0.47 5.94e-20 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.35 -5.7 -0.3 2.59e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17125944 0.505 rs74620173 chr14:53194068 G/T cg00686598 chr14:53173677 PSMC6 1.13 10.33 0.49 7.02e-22 Alzheimer's disease (late onset); LUSC trans rs8002861 0.967 rs9525871 chr13:44477712 A/T cg17145862 chr1:211918768 LPGAT1 0.23 6.01 0.31 4.76e-9 Leprosy; LUSC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg27572855 chr1:25598939 RHD 0.42 7.36 0.37 1.45e-12 Erythrocyte sedimentation rate; LUSC cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg22681709 chr2:178499509 PDE11A -0.48 -8.92 -0.44 3.19e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2944755 0.959 rs2977491 chr8:141574277 A/G cg08444833 chr8:141574162 EIF2C2 -0.47 -6.05 -0.31 3.94e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7086627 0.507 rs7077907 chr10:82017082 A/G cg01528321 chr10:82214614 TSPAN14 0.59 9.05 0.44 1.22e-17 Post bronchodilator FEV1; LUSC cis rs11098499 0.863 rs13140391 chr4:120503437 A/G cg24375607 chr4:120327624 NA 0.76 11.45 0.53 7.76e-26 Corneal astigmatism; LUSC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg21984481 chr17:79567631 NPLOC4 -0.56 -10.83 -0.51 1.23e-23 Eye color traits; LUSC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg04287289 chr16:89883240 FANCA 0.78 13.77 0.6 1.85e-34 Vitiligo; LUSC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg12386194 chr3:101231763 SENP7 0.63 8.73 0.43 1.22e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs637571 0.510 rs10750772 chr11:65577427 C/T cg26695010 chr11:65641043 EFEMP2 0.46 6.68 0.34 1.02e-10 Eosinophil percentage of white cells; LUSC cis rs59918340 0.728 rs2304279 chr8:142229891 A/G cg23750338 chr8:142222470 SLC45A4 0.58 11.04 0.52 2.3e-24 Immature fraction of reticulocytes; LUSC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg14583973 chr4:3374767 RGS12 0.33 7.17 0.37 4.71e-12 Serum sulfate level; LUSC cis rs9807841 0.670 rs2569512 chr19:10790162 A/G cg17710535 chr19:10819994 QTRT1 0.4 6.43 0.33 4.47e-10 Inflammatory skin disease; LUSC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg18876405 chr7:65276391 NA 0.6 9.71 0.47 8.76e-20 Aortic root size; LUSC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg23982607 chr1:1823379 GNB1 0.72 14.8 0.63 1.78e-38 Body mass index; LUSC cis rs7605827 0.930 rs11893253 chr2:15606618 A/G cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.36e-16 Educational attainment (years of education); LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg27284194 chr4:1044797 NA 0.35 5.98 0.31 5.85e-9 Obesity-related traits; LUSC trans rs9291683 0.595 rs35501905 chr4:10053431 C/T cg26043149 chr18:55253948 FECH 0.48 6.96 0.36 1.8e-11 Bone mineral density; LUSC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg06494592 chr3:125709126 NA -0.5 -5.76 -0.3 1.9e-8 Blood pressure (smoking interaction); LUSC cis rs7615316 1.000 rs6775813 chr3:142345623 A/C cg16271453 chr3:142027066 XRN1 -0.34 -5.82 -0.3 1.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs2204008 0.748 rs8186658 chr12:38301461 A/C cg06521331 chr12:34319734 NA -0.42 -6.51 -0.34 2.71e-10 Bladder cancer; LUSC cis rs1801251 1.000 rs13008942 chr2:233594875 G/A cg08000102 chr2:233561755 GIGYF2 0.68 11.42 0.53 9.96e-26 Coronary artery disease; LUSC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg16414030 chr3:133502952 NA -0.41 -6.47 -0.33 3.45e-10 Iron status biomarkers; LUSC cis rs7615316 0.725 rs7428289 chr3:142008699 A/G cg16271453 chr3:142027066 XRN1 -0.4 -7.05 -0.36 1.05e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg15147215 chr3:52552868 STAB1 -0.32 -6.26 -0.32 1.19e-9 Bipolar disorder; LUSC cis rs7772486 0.875 rs2814871 chr6:146312274 G/T cg05347473 chr6:146136440 FBXO30 0.51 8.53 0.42 5.01e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs9921338 0.961 rs9937269 chr16:11416679 A/G cg00044050 chr16:11439710 C16orf75 0.49 6.53 0.34 2.38e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg03233332 chr7:66118400 NA -0.43 -6.18 -0.32 1.83e-9 Aortic root size; LUSC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.28 0.32 1.08e-9 Height; LUSC cis rs74377301 1 rs74377301 chr7:123232495 C/T cg03229431 chr7:123269106 ASB15 -0.61 -9.19 -0.45 4.18e-18 Left ventricular obstructive tract defect (inherited effect); LUSC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.83 0.39 6.37e-14 Bipolar disorder; LUSC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg23985595 chr17:80112537 CCDC57 0.31 5.97 0.31 6.13e-9 Life satisfaction; LUSC cis rs10740039 0.883 rs7902632 chr10:62403569 G/T cg18175470 chr10:62150864 ANK3 -0.47 -6.96 -0.36 1.77e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6456156 0.774 rs1012656 chr6:167525303 G/C cg07741184 chr6:167504864 NA -0.34 -5.91 -0.31 8.59e-9 Primary biliary cholangitis; LUSC cis rs9462027 0.675 rs7755926 chr6:34722574 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.65 -0.3 3.5e-8 Systemic lupus erythematosus; LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg07167872 chr1:205819463 PM20D1 -0.52 -8.3 -0.41 2.61e-15 Menarche (age at onset); LUSC cis rs7589342 0.899 rs879900 chr2:106494347 A/G cg16077055 chr2:106428750 NCK2 0.32 5.94 0.31 7.17e-9 Addiction; LUSC trans rs4942242 1.000 rs9594987 chr13:44230994 C/T cg19169023 chr15:41853346 TYRO3 0.48 7.9 0.4 4.13e-14 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.04 -0.4 1.57e-14 Lymphocyte counts; LUSC cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC trans rs1923243 0.546 rs11210226 chr1:73854284 A/G ch.8.34907260F chr8:34787718 NA -0.4 -6.02 -0.31 4.66e-9 Migraine; LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.1 0.41 1.05e-14 Prudent dietary pattern; LUSC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs7939886 0.920 rs7107736 chr11:55987980 C/G cg15704280 chr7:45808275 SEPT13 0.9 6.77 0.35 5.92e-11 Myopia (pathological); LUSC cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg12573674 chr2:1569213 NA -0.57 -8.12 -0.41 9.19e-15 IgG glycosylation; LUSC cis rs765787 0.530 rs2899378 chr15:45537584 C/T cg25801113 chr15:45476975 SHF -0.36 -7.03 -0.36 1.19e-11 Uric acid levels; LUSC cis rs6599077 1.000 rs4676559 chr3:40090667 C/T cg13683864 chr3:40499215 RPL14 -0.56 -7.22 -0.37 3.44e-12 Sleep-related phenotypes; LUSC cis rs6066835 1.000 rs3746819 chr20:47307934 A/G cg18078177 chr20:47281410 PREX1 0.77 6.37 0.33 6.12e-10 Multiple myeloma; LUSC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.54 -7.05 -0.36 1.02e-11 Height; LUSC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg15605315 chr1:45957053 TESK2 0.48 7.94 0.4 3.1e-14 High light scatter reticulocyte count; LUSC cis rs4237845 0.804 rs10877034 chr12:58286444 T/C cg02175503 chr12:58329896 NA 0.61 9.88 0.48 2.39e-20 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg04553112 chr3:125709451 NA -0.51 -5.67 -0.3 3.12e-8 Blood pressure (smoking interaction); LUSC cis rs9359856 0.564 rs34732313 chr6:90368380 G/A cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.89 -0.44 3.94e-17 Bipolar disorder; LUSC cis rs10992471 0.603 rs7045572 chr9:95137964 T/C cg14631576 chr9:95140430 CENPP -0.37 -6.5 -0.33 3e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.99 0.36 1.46e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg02018176 chr4:1364513 KIAA1530 -0.57 -9.9 -0.48 2e-20 Obesity-related traits; LUSC cis rs2361710 0.704 rs12937349 chr17:78120320 G/C cg20811857 chr17:78079795 GAA -0.32 -6.08 -0.32 3.25e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs12893668 0.703 rs34026011 chr14:104050883 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -6.25 -0.32 1.28e-9 Reticulocyte count; LUSC cis rs9300255 0.602 rs1727296 chr12:123647725 G/C cg05973401 chr12:123451056 ABCB9 0.54 6.64 0.34 1.24e-10 Neutrophil percentage of white cells; LUSC cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs6961069 0.777 rs4731643 chr7:80248029 A/G cg04458919 chr7:80252533 CD36 -0.37 -6.59 -0.34 1.7e-10 Platelet count; LUSC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC trans rs6840360 0.642 rs2724577 chr4:152354905 C/G ch.11.1652751R chr11:76171117 C11orf30 0.49 6.28 0.32 1.07e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -5.92 -0.31 8.21e-9 Developmental language disorder (linguistic errors); LUSC cis rs2219968 1.000 rs13248343 chr8:78975745 A/G cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11209002 0.524 rs982131 chr1:67542360 T/C cg02640540 chr1:67518911 SLC35D1 0.62 8.56 0.42 4.25e-16 Crohn's disease; LUSC cis rs1372520 0.577 rs748849 chr4:90734961 G/A cg01966878 chr4:90757139 SNCA -0.43 -6.26 -0.32 1.22e-9 Neuroticism; LUSC cis rs4664308 0.870 rs1870104 chr2:161032285 A/G cg03641300 chr2:160917029 PLA2R1 -0.64 -10.9 -0.51 7.12e-24 Idiopathic membranous nephropathy; LUSC cis rs734999 0.545 rs7368072 chr1:2556125 C/T cg18854424 chr1:2615690 NA 0.5 10.05 0.48 6.38e-21 Ulcerative colitis; LUSC cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg24642439 chr20:33292090 TP53INP2 0.48 7.35 0.37 1.51e-12 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.24 0.37 3.11e-12 Bipolar disorder; LUSC cis rs832540 0.902 rs194059 chr5:56197416 G/A cg12311346 chr5:56204834 C5orf35 -0.61 -9.34 -0.45 1.44e-18 Coronary artery disease; LUSC trans rs7726839 0.540 rs7434 chr5:660804 A/G cg25482853 chr8:67687455 SGK3 -1.09 -15.98 -0.66 4.46e-43 Obesity-related traits; LUSC cis rs2439831 0.681 rs1095386 chr15:43609509 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.07 15.18 0.64 5.83e-40 Lung cancer in ever smokers; LUSC cis rs870825 0.655 rs10013685 chr4:185617785 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.7e-32 Blood protein levels; LUSC trans rs3808502 0.534 rs1529858 chr8:11145662 G/T cg06636001 chr8:8085503 FLJ10661 0.49 7.08 0.36 8.67e-12 Neuroticism; LUSC cis rs6496044 0.547 rs1564719 chr15:86054266 C/T cg13263323 chr15:86062960 AKAP13 -0.36 -5.99 -0.31 5.34e-9 Interstitial lung disease; LUSC cis rs8060686 0.546 rs8047343 chr16:68143745 G/A cg26727032 chr16:67993705 SLC12A4 -0.42 -6.71 -0.34 8.2e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg21535247 chr6:8435926 SLC35B3 0.6 9.37 0.46 1.13e-18 Motion sickness; LUSC cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.79 0.7 2.73e-50 Chronic sinus infection; LUSC cis rs9815354 0.857 rs9816772 chr3:41872877 C/T cg03022575 chr3:42003672 ULK4 0.59 6.58 0.34 1.77e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs6998277 0.830 rs12543008 chr8:103603747 C/T cg10187029 chr8:103597600 NA 0.8 12.4 0.56 2.76e-29 Migraine; LUSC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg02569458 chr12:86230093 RASSF9 0.55 9.38 0.46 1.01e-18 Major depressive disorder; LUSC cis rs6546537 0.910 rs10779953 chr2:69886757 A/G cg10773587 chr2:69614142 GFPT1 -0.49 -7.48 -0.38 6.62e-13 Serum thyroid-stimulating hormone levels; LUSC trans rs10435719 0.834 rs11250176 chr8:11792816 A/G cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.64e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.22 0.88 3.18e-111 Chronic sinus infection; LUSC cis rs1215050 0.791 rs649866 chr4:98738826 T/C cg05340658 chr4:99064831 C4orf37 0.43 6.79 0.35 5.28e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg20503657 chr10:835505 NA 0.97 12.79 0.57 9.13e-31 Eosinophil percentage of granulocytes; LUSC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg16405210 chr4:1374714 KIAA1530 -0.64 -10.33 -0.49 6.97e-22 Longevity; LUSC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg25039879 chr17:56429692 SUPT4H1 0.72 9.79 0.47 4.65e-20 Cognitive test performance; LUSC cis rs9534288 0.956 rs2094244 chr13:46605803 T/C cg15192986 chr13:46630673 CPB2 -0.74 -11.78 -0.54 4.87e-27 Blood protein levels; LUSC cis rs11229555 0.609 rs12273635 chr11:58186327 T/C cg15696309 chr11:58395628 NA -0.64 -7.78 -0.39 9.19e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg05393297 chr12:53359155 NA -0.71 -10.57 -0.5 1.05e-22 Cancer (pleiotropy); LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs9287719 0.674 rs759399 chr2:10796883 T/C cg02196655 chr2:10830764 NOL10 0.34 5.76 0.3 1.89e-8 Prostate cancer; LUSC cis rs1113500 0.814 rs1592282 chr1:108601365 T/C cg06207961 chr1:108661230 NA 0.3 5.65 0.3 3.53e-8 Growth-regulated protein alpha levels; LUSC trans rs4713118 0.515 rs9368549 chr6:28050047 T/A cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Parkinson's disease; LUSC cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg13256891 chr4:100009986 ADH5 -0.43 -6.0 -0.31 5.06e-9 Alcohol dependence; LUSC cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg13770153 chr20:60521292 NA -0.61 -8.39 -0.42 1.43e-15 Body mass index; LUSC cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg23583168 chr7:148888333 NA -0.88 -16.87 -0.68 1.31e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4566357 1.000 rs4566357 chr2:227922015 C/T cg11843606 chr2:227700838 RHBDD1 0.41 5.7 0.3 2.59e-8 Coronary artery disease; LUSC cis rs7759001 0.857 rs6456778 chr6:27370046 T/G cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC trans rs11098499 0.954 rs1022145 chr4:120230979 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.59 0.38 3.13e-13 Corneal astigmatism; LUSC cis rs34779708 0.897 rs12830 chr10:35302705 C/T cg03585969 chr10:35415529 CREM 0.65 9.4 0.46 9.06e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg07677032 chr17:61819896 STRADA 0.52 8.78 0.43 8.47e-17 Prudent dietary pattern; LUSC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg10523679 chr1:76189770 ACADM 0.89 12.46 0.56 1.56e-29 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17152411 1.000 rs17152411 chr10:126649516 A/G cg07906193 chr10:126599966 NA 0.38 5.7 0.3 2.66e-8 Height; LUSC cis rs8113142 0.614 rs1861173 chr19:29128097 C/A cg04546413 chr19:29218101 NA 0.45 6.24 0.32 1.29e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg15839431 chr19:19639596 YJEFN3 -0.62 -6.47 -0.33 3.47e-10 Bipolar disorder; LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg08888203 chr3:10149979 C3orf24 0.66 9.28 0.45 2.15e-18 Alzheimer's disease; LUSC trans rs7824557 1.000 rs7824557 chr8:11104111 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.14 -0.41 8.05e-15 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg07677032 chr17:61819896 STRADA 0.54 8.96 0.44 2.42e-17 Prudent dietary pattern; LUSC trans rs60787346 0.883 rs2838334 chr21:45064961 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.15 0.32 2.16e-9 Coronary artery disease; LUSC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg02807482 chr3:125708958 NA -0.53 -7.02 -0.36 1.27e-11 Blood pressure (smoking interaction); LUSC cis rs11958404 0.932 rs111802867 chr5:157424971 G/A cg05962755 chr5:157440814 NA 0.55 6.44 0.33 4.08e-10 IgG glycosylation; LUSC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11644478 chr21:40555479 PSMG1 0.9 16.45 0.67 5.98e-45 Cognitive function; LUSC cis rs60015123 1.000 rs34962575 chr12:7114074 A/C cg26269324 chr12:6977084 TPI1 0.78 6.16 0.32 2.06e-9 Red cell distribution width; LUSC cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg13319975 chr6:146136371 FBXO30 0.48 7.26 0.37 2.74e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs8017423 0.967 rs55962513 chr14:90729460 C/G cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs9815354 1.000 rs56207540 chr3:41976627 G/C cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1448094 0.842 rs7966352 chr12:86438705 A/C cg02569458 chr12:86230093 RASSF9 0.39 6.26 0.32 1.17e-9 Major depressive disorder; LUSC cis rs208520 0.802 rs1342959 chr6:66883329 A/G cg07460842 chr6:66804631 NA -1.05 -15.66 -0.65 7.51e-42 Exhaled nitric oxide output; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg18099408 chr3:52552593 STAB1 -0.35 -6.01 -0.31 4.88e-9 Electroencephalogram traits; LUSC cis rs12122100 0.651 rs12743228 chr1:146548275 G/A cg03526459 chr1:146549940 NA -0.41 -6.56 -0.34 2.04e-10 HIV-1 control; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12862548 chr5:93954431 ANKRD32;C5orf36 0.43 6.17 0.32 1.99e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs73110464 0.505 rs2638503 chr12:53307369 C/G cg05393297 chr12:53359155 NA -0.36 -6.46 -0.33 3.7e-10 Cancer (pleiotropy); LUSC cis rs11098499 0.826 rs4472123 chr4:120236630 T/A cg24375607 chr4:120327624 NA 0.76 11.9 0.55 1.79e-27 Corneal astigmatism; LUSC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg06850241 chr22:41845214 NA -0.32 -5.95 -0.31 6.61e-9 Vitiligo; LUSC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg19774624 chr17:42201019 HDAC5 0.82 14.31 0.62 1.44e-36 Total body bone mineral density; LUSC cis rs6089584 0.527 rs927589 chr20:60606363 A/G cg24733560 chr20:60626293 TAF4 0.44 8.09 0.4 1.11e-14 Body mass index; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 15.14 0.64 8.98e-40 Platelet count; LUSC cis rs9796 0.621 rs2918462 chr15:41481254 A/G cg18705301 chr15:41695430 NDUFAF1 0.5 8.93 0.44 2.91e-17 Menopause (age at onset); LUSC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg15448220 chr1:150897856 SETDB1 -0.39 -5.73 -0.3 2.27e-8 Melanoma; LUSC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg12311346 chr5:56204834 C5orf35 0.65 9.8 0.47 4.4e-20 Type 2 diabetes; LUSC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg19748678 chr4:122722346 EXOSC9 0.73 10.65 0.5 5.39e-23 Type 2 diabetes; LUSC cis rs6087990 0.735 rs1040555 chr20:31380201 A/T cg13636640 chr20:31349939 DNMT3B -0.9 -18.75 -0.72 4.22e-54 Ulcerative colitis; LUSC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.77 -0.3 1.85e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12711979 0.740 rs6715434 chr2:3820862 T/G cg17052675 chr2:3827356 NA -0.58 -11.38 -0.53 1.42e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs6733011 0.600 rs1356424 chr2:99425838 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.28 -0.33 1.03e-9 Bipolar disorder; LUSC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg13393036 chr8:95962371 TP53INP1 -0.46 -9.57 -0.46 2.49e-19 Type 2 diabetes; LUSC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.92 -0.35 2.31e-11 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg17366294 chr4:99064904 C4orf37 0.58 9.85 0.47 2.87e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.632 rs7206546 chr16:89799079 C/T cg01097406 chr16:89675127 NA 0.33 6.44 0.33 4.24e-10 Vitiligo; LUSC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg06008330 chr7:65541103 ASL 0.37 5.68 0.3 2.98e-8 Aortic root size; LUSC cis rs10782582 0.609 rs5745331 chr1:76273313 A/G cg03433033 chr1:76189801 ACADM -0.42 -6.21 -0.32 1.57e-9 Daytime sleep phenotypes; LUSC cis rs295140 1.000 rs55677233 chr2:201168695 T/C cg04283868 chr2:201171347 SPATS2L 0.44 6.63 0.34 1.36e-10 QT interval; LUSC cis rs477692 0.625 rs4751104 chr10:131405358 G/A cg05714579 chr10:131428358 MGMT -0.71 -11.38 -0.53 1.4e-25 Response to temozolomide; LUSC cis rs7312933 0.584 rs6582391 chr12:42634686 G/A cg17420585 chr12:42539391 GXYLT1 -0.34 -6.48 -0.33 3.32e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.49 -6.22 -0.32 1.45e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs34421088 0.532 rs2736258 chr8:11170449 C/T cg15556689 chr8:8085844 FLJ10661 0.46 6.37 0.33 6.1e-10 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12152867 chr6:56708725 DST -0.48 -6.43 -0.33 4.39e-10 Bipolar disorder and schizophrenia; LUSC cis rs9287719 0.967 rs10929686 chr2:10743705 A/C cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs4930103 0.782 rs10840167 chr11:2022023 G/T cg06197492 chr11:2016605 H19 0.41 6.71 0.34 8.55e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg22681709 chr2:178499509 PDE11A -0.51 -9.18 -0.45 4.5e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9916302 0.706 rs667239 chr17:37442241 A/G cg07936489 chr17:37558343 FBXL20 0.82 10.53 0.5 1.37e-22 Glomerular filtration rate (creatinine); LUSC cis rs6121246 0.523 rs6060286 chr20:30197663 C/A cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg16680214 chr1:154839983 KCNN3 -0.57 -11.2 -0.52 6.14e-25 Prostate cancer; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg25072359 chr17:41440525 NA 0.68 9.69 0.47 9.97e-20 Menopause (age at onset); LUSC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.52 0.38 4.99e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3857536 0.740 rs7745163 chr6:66889936 A/G cg07460842 chr6:66804631 NA -0.47 -6.54 -0.34 2.29e-10 Blood trace element (Cu levels); LUSC cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1950500 1.000 rs1950500 chr14:24830850 T/C cg16194253 chr14:24768981 DHRS1;C14orf21 0.48 6.29 0.33 1.02e-9 Height; LUSC trans rs12543645 0.598 rs17767186 chr8:10277494 C/T cg15556689 chr8:8085844 FLJ10661 0.44 6.17 0.32 2.02e-9 Schizophrenia; LUSC cis rs9467773 0.595 rs3846845 chr6:26444915 G/A cg09904177 chr6:26538194 HMGN4 -0.57 -8.72 -0.43 1.3e-16 Intelligence (multi-trait analysis); LUSC cis rs35883536 0.647 rs2647325 chr1:101040195 T/C cg09408571 chr1:101003634 GPR88 0.29 5.84 0.3 1.25e-8 Monocyte count; LUSC trans rs12200782 0.769 rs10456329 chr6:26436399 G/A cg11837749 chr1:55047332 ACOT11 0.52 6.2 0.32 1.67e-9 Small cell lung carcinoma; LUSC cis rs7647973 1.000 rs6785045 chr3:49435243 G/C cg07636037 chr3:49044803 WDR6 -0.69 -9.2 -0.45 4.05e-18 Menarche (age at onset); LUSC cis rs9560113 1.000 rs61967684 chr13:112178026 G/C cg14154082 chr13:112174009 NA 0.38 7.76 0.39 1.03e-13 Menarche (age at onset); LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.29e-12 Platelet count; LUSC cis rs1371867 0.641 rs1788209 chr8:101337056 C/T cg06636551 chr8:101224915 SPAG1 -0.4 -7.35 -0.37 1.52e-12 Atrioventricular conduction; LUSC cis rs9392556 0.829 rs659305 chr6:4125655 A/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -6.64 -0.34 1.27e-10 Blood metabolite levels; LUSC cis rs6906287 0.552 rs7740645 chr6:118929208 T/A cg21191810 chr6:118973309 C6orf204 0.32 5.96 0.31 6.53e-9 Electrocardiographic conduction measures; LUSC cis rs1348850 0.651 rs1901824 chr2:178225466 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.58 0.34 1.8e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6484504 0.600 rs208063 chr11:31159777 C/T cg06552810 chr11:31128660 NA -0.38 -6.86 -0.35 3.42e-11 Red blood cell count; LUSC cis rs7520050 0.801 rs6703960 chr1:46232723 C/T cg24296786 chr1:45957014 TESK2 0.41 5.84 0.3 1.24e-8 Red blood cell count;Reticulocyte count; LUSC cis rs2398893 0.924 rs7855830 chr9:96798659 A/G cg14459158 chr9:96720562 NA 0.29 5.71 0.3 2.47e-8 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg16362232 chr11:430036 ANO9 0.68 8.52 0.42 5.61e-16 Body mass index; LUSC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg11062466 chr8:58055876 NA 0.5 6.45 0.33 3.85e-10 Developmental language disorder (linguistic errors); LUSC cis rs7715806 0.517 rs34340 chr5:74932099 A/C cg06933384 chr5:74808293 COL4A3BP;POLK 0.39 5.65 0.3 3.41e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs660498 0.507 rs765700 chr10:27734885 G/A cg04084786 chr10:27609163 NA 0.39 5.76 0.3 1.96e-8 Asthma (childhood onset); LUSC cis rs11583043 0.708 rs36023027 chr1:101575205 T/C cg11406453 chr1:101602562 NA -0.4 -6.94 -0.36 2.03e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7917772 0.507 rs2778036 chr10:104485725 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 7.96 0.4 2.8e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs61863818 0.557 rs7898743 chr10:99153540 T/G cg20016023 chr10:99160130 RRP12 -0.27 -6.74 -0.35 6.91e-11 Monocyte percentage of white cells; LUSC cis rs10779751 0.770 rs1417131 chr1:11191922 T/C cg08854313 chr1:11322531 MTOR -0.82 -12.52 -0.57 9.1e-30 Body mass index; LUSC cis rs4595586 0.545 rs6580910 chr12:39390052 C/A cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg10360139 chr7:1886902 MAD1L1 -0.46 -7.16 -0.36 5.12e-12 Bipolar disorder and schizophrenia; LUSC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg18876405 chr7:65276391 NA 0.58 9.4 0.46 8.87e-19 Aortic root size; LUSC cis rs8036030 0.604 rs11856835 chr15:74716174 G/A cg10253484 chr15:75165896 SCAMP2 -0.48 -7.24 -0.37 3.06e-12 Airflow obstruction; LUSC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg17178900 chr1:205818956 PM20D1 -0.78 -13.36 -0.59 6.3e-33 Menarche (age at onset); LUSC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg19622623 chr12:86230825 RASSF9 -0.4 -5.7 -0.3 2.69e-8 Major depressive disorder; LUSC cis rs11168618 0.846 rs11168599 chr12:48879951 A/C cg24011408 chr12:48396354 COL2A1 0.37 6.02 0.31 4.7e-9 Adiponectin levels; LUSC cis rs10892173 0.566 rs111578166 chr11:117666714 G/T cg07621104 chr11:117668040 DSCAML1 0.51 6.82 0.35 4.18e-11 Myopia; LUSC cis rs6696846 0.765 rs3738155 chr1:205074424 C/T cg00857998 chr1:205179979 DSTYK 0.64 10.11 0.48 3.78e-21 Red blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04371528 chr3:20081516 KAT2B 0.46 6.53 0.34 2.39e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg24642844 chr7:1081250 C7orf50 -0.64 -9.19 -0.45 4.28e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1878931 0.580 rs3848355 chr16:3407489 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.87 16.82 0.68 1.96e-46 Body mass index (adult); LUSC cis rs1559088 0.847 rs10416218 chr19:33599127 T/C cg03563238 chr19:33554763 RHPN2 -0.4 -6.43 -0.33 4.3e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg16049864 chr8:95962084 TP53INP1 0.57 10.6 0.5 7.78e-23 Type 2 diabetes; LUSC cis rs9815354 0.761 rs12635286 chr3:42051836 T/C cg03022575 chr3:42003672 ULK4 0.61 6.44 0.33 4.06e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs1371867 0.846 rs1660326 chr8:101290447 G/A cg06002616 chr8:101225028 SPAG1 -0.45 -7.28 -0.37 2.36e-12 Atrioventricular conduction; LUSC cis rs71403859 0.667 rs12920890 chr16:71787588 G/A cg08717414 chr16:71523259 ZNF19 -0.64 -7.06 -0.36 9.68e-12 Post bronchodilator FEV1; LUSC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg24920358 chr1:40204285 PPIE -0.61 -10.93 -0.51 5.64e-24 Blood protein levels; LUSC cis rs7267979 1.000 rs4815424 chr20:25390284 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.7 -0.73 7.16e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.52 0.42 5.63e-16 Prudent dietary pattern; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -12.08 -0.55 3.96e-28 Alzheimer's disease; LUSC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.8 0.47 4.41e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg08859206 chr1:53392774 SCP2 -0.44 -7.56 -0.38 3.88e-13 Monocyte count; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 13.17 0.58 3.39e-32 Alzheimer's disease; LUSC cis rs12421382 0.659 rs1866530 chr11:109380899 T/A cg16359550 chr11:109292809 C11orf87 0.35 6.05 0.31 3.96e-9 Schizophrenia; LUSC trans rs629535 0.814 rs549643 chr8:70062884 C/T cg21567404 chr3:27674614 NA 0.96 15.28 0.64 2.49e-40 Dupuytren's disease; LUSC cis rs17125944 0.686 rs76673112 chr14:53366692 T/C cg00686598 chr14:53173677 PSMC6 0.86 7.54 0.38 4.57e-13 Alzheimer's disease (late onset); LUSC cis rs4820294 1.000 rs62236668 chr22:38063870 G/A cg21798802 chr22:38057573 PDXP 0.48 10.64 0.5 6.02e-23 Fat distribution (HIV); LUSC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg06634786 chr22:41940651 POLR3H -0.54 -6.15 -0.32 2.25e-9 Vitiligo; LUSC cis rs1200821 0.529 rs2505707 chr10:37801254 T/C cg25427524 chr10:38739819 LOC399744 -0.39 -6.38 -0.33 5.94e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg15691649 chr6:25882328 NA -0.38 -6.21 -0.32 1.58e-9 Blood metabolite levels; LUSC cis rs9467773 1.000 rs9467773 chr6:26498426 A/G cg05738196 chr6:26577821 NA 0.79 14.86 0.63 1.05e-38 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg23978390 chr7:1156363 C7orf50 0.53 7.48 0.38 6.61e-13 Longevity;Endometriosis; LUSC cis rs7605827 0.897 rs6431694 chr2:15523031 T/C cg19274914 chr2:15703543 NA 0.47 9.27 0.45 2.39e-18 Educational attainment (years of education); LUSC cis rs12543725 0.601 rs7018178 chr8:142239210 C/T cg23750338 chr8:142222470 SLC45A4 -0.34 -6.39 -0.33 5.46e-10 Birth weight; LUSC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg04362960 chr10:104952993 NT5C2 0.59 9.47 0.46 5.39e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg16049864 chr8:95962084 TP53INP1 -0.43 -7.21 -0.37 3.66e-12 Type 2 diabetes; LUSC cis rs13217239 0.646 rs4269366 chr6:27016413 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.3 6.18 0.32 1.86e-9 Schizophrenia; LUSC cis rs654950 0.783 rs639298 chr1:42001530 A/G cg06885757 chr1:42089581 HIVEP3 -0.34 -6.52 -0.34 2.65e-10 Airway imaging phenotypes; LUSC cis rs929354 0.772 rs3802124 chr7:156970609 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs7904985 1.000 rs12358144 chr10:88114486 C/G cg07322936 chr10:88137208 NA -0.57 -7.32 -0.37 1.81e-12 Barrett's esophagus; LUSC cis rs968567 0.539 rs174555 chr11:61579760 T/C cg19610905 chr11:61596333 FADS2 -0.54 -7.88 -0.4 4.52e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg18681998 chr4:17616180 MED28 0.83 14.9 0.63 7.16e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs11992162 0.591 rs4240678 chr8:11802426 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.29 -0.37 2.29e-12 Monocyte count; LUSC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg03929089 chr4:120376271 NA -0.94 -16.31 -0.67 2.11e-44 Height; LUSC cis rs62380364 0.602 rs665324 chr5:88055517 T/C cg22951263 chr5:87985283 NA -0.46 -7.53 -0.38 4.89e-13 Intelligence (multi-trait analysis); LUSC cis rs9393777 0.622 rs13191326 chr6:27031029 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.53 -6.0 -0.31 5.25e-9 Intelligence (multi-trait analysis); LUSC cis rs9309473 0.519 rs2421583 chr2:73898785 C/G cg20560298 chr2:73613845 ALMS1 0.48 7.26 0.37 2.76e-12 Metabolite levels; LUSC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08704250 chr15:31115839 NA -0.47 -7.03 -0.36 1.17e-11 Huntington's disease progression; LUSC cis rs12928939 0.815 rs8049163 chr16:71719353 C/T cg03805757 chr16:71968109 PKD1L3 -0.4 -5.74 -0.3 2.13e-8 Post bronchodilator FEV1; LUSC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg07777115 chr5:623756 CEP72 -0.46 -5.74 -0.3 2.09e-8 Obesity-related traits; LUSC cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg14343924 chr8:8086146 FLJ10661 -0.43 -5.79 -0.3 1.66e-8 Mood instability; LUSC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg12310025 chr6:25882481 NA -0.41 -7.31 -0.37 1.93e-12 Height; LUSC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg22676075 chr6:135203613 NA 0.55 8.72 0.43 1.37e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg27535305 chr1:53392650 SCP2 0.52 10.01 0.48 8.43e-21 Monocyte count; LUSC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.41 0.53 1.14e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11864453 0.514 rs2269918 chr16:72134831 C/A cg01557791 chr16:72042693 DHODH -0.43 -6.53 -0.34 2.42e-10 Fibrinogen levels; LUSC cis rs4986172 0.655 rs1044977 chr17:43227214 T/C cg10701640 chr17:43249399 NA 0.47 10.0 0.48 8.96e-21 Height; LUSC cis rs9653442 0.835 rs11694875 chr2:100732845 A/G cg07810366 chr2:100720526 AFF3 0.53 9.48 0.46 4.89e-19 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.42e-17 Prudent dietary pattern; LUSC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg11764359 chr7:65958608 NA 0.61 9.21 0.45 3.66e-18 Aortic root size; LUSC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs12545109 0.642 rs2055984 chr8:57418332 A/G cg09654669 chr8:57350985 NA -0.52 -6.33 -0.33 7.94e-10 Obesity-related traits; LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg12432903 chr7:1882776 MAD1L1 -0.51 -8.71 -0.43 1.47e-16 Bipolar disorder and schizophrenia; LUSC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg00074818 chr8:8560427 CLDN23 0.54 9.39 0.46 9.83e-19 Obesity-related traits; LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs17433780 0.897 rs17434151 chr1:89500526 G/T cg09516651 chr1:89888402 LOC400759 0.58 10.0 0.48 8.92e-21 Carotid intima media thickness; LUSC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs1801251 1.000 rs3817311 chr2:233612557 C/T cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.34 2.87e-10 Coronary artery disease; LUSC cis rs734999 0.505 rs4073286 chr1:2539901 A/C cg18932078 chr1:2524107 MMEL1 0.29 6.26 0.32 1.18e-9 Ulcerative colitis; LUSC trans rs2797160 1.000 rs1832980 chr6:125997444 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.47 -0.33 3.53e-10 Endometrial cancer; LUSC cis rs4343996 0.626 rs7791898 chr7:3398325 C/T cg21248987 chr7:3385318 SDK1 -0.37 -6.21 -0.32 1.61e-9 Motion sickness; LUSC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg00933542 chr6:150070202 PCMT1 0.29 5.95 0.31 6.66e-9 Lung cancer; LUSC cis rs72781680 0.898 rs72796166 chr2:23939311 G/C cg08917208 chr2:24149416 ATAD2B 0.99 10.09 0.48 4.53e-21 Lymphocyte counts; LUSC cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg08999081 chr20:33150536 PIGU 0.37 6.81 0.35 4.46e-11 Height; LUSC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg03354898 chr7:1950403 MAD1L1 0.34 6.67 0.34 1.09e-10 Bipolar disorder and schizophrenia; LUSC cis rs13064411 0.627 rs9825827 chr3:113182231 T/C cg18753928 chr3:113234510 CCDC52 -0.53 -8.27 -0.41 3.16e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs977987 0.800 rs3784935 chr16:75336430 T/G cg04384234 chr16:75411784 CFDP1 -0.36 -5.68 -0.3 2.97e-8 Dupuytren's disease; LUSC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg24397884 chr7:158709396 WDR60 0.68 11.89 0.55 2.03e-27 Height; LUSC cis rs9399401 0.626 rs13198644 chr6:142783233 A/G cg04461802 chr6:142623433 GPR126 0.46 5.9 0.31 8.97e-9 Chronic obstructive pulmonary disease; LUSC cis rs7119 0.717 rs7181283 chr15:77814544 G/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs6665290 0.935 rs1929863 chr1:227195728 C/T cg10327440 chr1:227177885 CDC42BPA -1.21 -40.31 -0.91 2.47e-130 Myeloid white cell count; LUSC trans rs11088226 1.000 rs11088226 chr21:33925531 C/G cg09050820 chr6:167586206 TCP10L2 0.53 7.23 0.37 3.37e-12 Gastritis; LUSC cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7119038 0.818 rs715412 chr11:118684610 G/A cg19308663 chr11:118741387 NA 0.36 6.3 0.33 9.39e-10 Sjögren's syndrome; LUSC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg18252515 chr7:66147081 NA -0.39 -5.66 -0.3 3.22e-8 Aortic root size; LUSC cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg26384229 chr12:38710491 ALG10B 0.88 14.94 0.63 5.21e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs7829975 0.582 rs6982832 chr8:8792217 A/C cg15556689 chr8:8085844 FLJ10661 -0.6 -9.92 -0.48 1.72e-20 Mood instability; LUSC cis rs7917772 0.582 rs10786685 chr10:104323103 C/T cg05855489 chr10:104503620 C10orf26 -0.48 -7.4 -0.38 1.09e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1728785 0.901 rs1645934 chr16:68564490 T/A cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs1355223 1.000 rs11602909 chr11:34768003 T/C cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.85 -0.31 1.14e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs911119 0.913 rs1158167 chr20:23578189 G/A cg16589663 chr20:23618590 CST3 -0.56 -6.6 -0.34 1.57e-10 Chronic kidney disease; LUSC cis rs524023 0.874 rs506338 chr11:64440920 T/C cg07220939 chr11:64358617 SLC22A12 -0.21 -5.68 -0.3 2.86e-8 Urate levels in obese individuals; LUSC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.4 7.94 0.4 3.05e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs853679 0.546 rs200977 chr6:27854301 T/C cg06606381 chr12:133084897 FBRSL1 -0.81 -7.48 -0.38 6.5e-13 Depression; LUSC cis rs9467773 1.000 rs2208331 chr6:26507319 A/G cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.97e-18 Intelligence (multi-trait analysis); LUSC cis rs17604090 1.000 rs67970052 chr7:29655038 C/T cg19413766 chr7:29689036 LOC646762 -0.59 -6.84 -0.35 3.89e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7572644 0.640 rs7593136 chr2:28017792 A/G cg27432699 chr2:27873401 GPN1 0.56 7.26 0.37 2.75e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7618501 1.000 rs7649348 chr3:49772375 G/A cg13072238 chr3:49761600 GMPPB -0.39 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs10791323 0.572 rs4412766 chr11:133742811 A/C cg15485101 chr11:133734466 NA 0.39 7.04 0.36 1.08e-11 Childhood ear infection; LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg20821713 chr7:1055600 C7orf50 -0.47 -7.64 -0.39 2.33e-13 Longevity;Endometriosis; LUSC cis rs9467711 0.606 rs9393714 chr6:26373740 G/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg09455208 chr3:40491958 NA 0.56 10.12 0.48 3.46e-21 Renal cell carcinoma; LUSC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg02018176 chr4:1364513 KIAA1530 0.45 7.45 0.38 7.89e-13 Obesity-related traits; LUSC cis rs9517320 0.515 rs61969456 chr13:99174799 C/G cg07423050 chr13:99094983 FARP1 -0.55 -10.19 -0.49 2.04e-21 Longevity; LUSC cis rs1395 0.778 rs17005956 chr2:27451099 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.47 7.0 0.36 1.44e-11 Blood metabolite levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21257117 chr11:65029643 POLA2 0.42 6.07 0.32 3.57e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg00409905 chr10:38381863 ZNF37A -0.35 -5.98 -0.31 5.82e-9 Extrinsic epigenetic age acceleration; LUSC cis rs12220238 1.000 rs12359456 chr10:75937994 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.89 0.35 2.71e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg20818283 chr2:191399100 TMEM194B -0.42 -6.62 -0.34 1.48e-10 Pulse pressure; LUSC cis rs12291225 0.546 rs12795545 chr11:14355564 G/A cg19336497 chr11:14380999 RRAS2 -0.6 -13.54 -0.6 1.31e-33 Sense of smell; LUSC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg07716408 chr11:68623521 NA -0.3 -5.73 -0.3 2.27e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg16447950 chr5:562315 NA -0.54 -6.69 -0.34 9.21e-11 Obesity-related traits; LUSC cis rs7605827 0.930 rs7588148 chr2:15706392 G/A cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.74e-17 Educational attainment (years of education); LUSC cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9287719 0.967 rs6750891 chr2:10738563 T/C cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs7582720 1.000 rs77268589 chr2:203751981 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7512552 0.839 rs1260421 chr1:150357780 G/A cg15654264 chr1:150340011 RPRD2 0.66 10.96 0.51 4.44e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs11122272 0.735 rs2486737 chr1:231520523 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg13175981 chr1:150552382 MCL1 0.43 6.12 0.32 2.66e-9 Tonsillectomy; LUSC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg16680214 chr1:154839983 KCNN3 -0.55 -10.3 -0.49 8.87e-22 Prostate cancer; LUSC cis rs6982240 0.514 rs10088801 chr8:142275801 T/C cg00131261 chr8:142287264 NA -0.36 -6.05 -0.31 3.99e-9 Tonsillectomy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27337868 chr5:139944050 APBB3;SLC35A4 -0.37 -5.95 -0.31 6.78e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4474465 0.850 rs4590904 chr11:78263847 C/T cg27205649 chr11:78285834 NARS2 0.5 5.87 0.31 1.04e-8 Alzheimer's disease (survival time); LUSC cis rs711245 1.000 rs848602 chr2:36778372 G/A cg09467607 chr2:36825704 FEZ2 0.4 8.33 0.41 2.06e-15 Height; LUSC trans rs116175374 0.793 rs6709207 chr2:31431064 C/T cg15543616 chr12:5019024 KCNA1 -0.77 -6.01 -0.31 4.9e-9 Endometriosis; LUSC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg14196790 chr5:131705035 SLC22A5 0.36 6.0 0.31 5.21e-9 Blood metabolite levels; LUSC cis rs8060686 0.641 rs12446007 chr16:68189054 C/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs12310956 0.510 rs4931758 chr12:33871870 C/T cg06521331 chr12:34319734 NA -0.37 -6.17 -0.32 2.03e-9 Morning vs. evening chronotype; LUSC cis rs7223966 1.000 rs7220892 chr17:61908316 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.73 0.35 7.51e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg05347473 chr6:146136440 FBXO30 -0.56 -9.71 -0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs8049040 0.609 rs4258624 chr16:71467951 C/T cg08717414 chr16:71523259 ZNF19 0.4 5.81 0.3 1.48e-8 Blood protein levels; LUSC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg12463550 chr7:65579703 CRCP -0.55 -8.03 -0.4 1.68e-14 Aortic root size; LUSC cis rs7191439 0.858 rs4238685 chr16:88775220 T/C cg02389323 chr16:88786976 FAM38A 1.17 10.58 0.5 9.66e-23 Plateletcrit; LUSC trans rs4912314 1.000 rs4912314 chr1:56968477 A/G cg13443768 chr11:65084386 CDC42EP2 -0.33 -6.14 -0.32 2.39e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.32 -0.33 8.54e-10 Lung cancer; LUSC cis rs4268898 0.552 rs7560342 chr2:24371691 T/C cg06627628 chr2:24431161 ITSN2 0.52 7.29 0.37 2.29e-12 Asthma; LUSC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg14552801 chr7:65878734 NA -0.38 -5.9 -0.31 8.98e-9 Aortic root size; LUSC cis rs2953174 0.938 rs2975763 chr2:241533845 T/C cg07929629 chr2:241523174 NA 0.46 5.98 0.31 5.59e-9 Bipolar disorder; LUSC cis rs2295359 1.000 rs4655682 chr1:67610967 C/T cg12940439 chr1:67600707 NA 0.38 6.28 0.33 1.04e-9 Psoriasis; LUSC cis rs427394 0.659 rs274717 chr5:6721067 C/T cg10857441 chr5:6722123 POLS 0.46 8.51 0.42 6.12e-16 Menopause (age at onset); LUSC cis rs6542838 0.702 rs4851167 chr2:99496303 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.78 -0.3 1.71e-8 Fear of minor pain; LUSC trans rs35110281 0.748 rs162403 chr21:44963365 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 11.11 0.52 1.33e-24 Mean corpuscular volume; LUSC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg15147215 chr3:52552868 STAB1 -0.31 -6.16 -0.32 2.06e-9 Bipolar disorder; LUSC cis rs1570884 0.516 rs7330830 chr13:50167929 T/A cg03651054 chr13:50194643 NA 0.35 5.9 0.31 8.94e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06635371 chr11:62554837 TMEM179B 0.47 6.33 0.33 8e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4363385 0.818 rs12029168 chr1:152987993 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.61 -0.38 2.91e-13 Inflammatory skin disease; LUSC cis rs1577917 1.000 rs12216203 chr6:86675301 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.87 -0.35 3.13e-11 Response to antipsychotic treatment; LUSC cis rs13006833 0.694 rs291448 chr2:191177216 T/C cg21644426 chr2:191273491 MFSD6 0.43 6.16 0.32 2.13e-9 Urinary metabolites; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02084808 chr1:172413246 PIGC;C1orf105 0.77 5.97 0.31 5.97e-9 Cognitive performance; LUSC cis rs2742234 0.614 rs3026750 chr10:43607756 G/A cg15436174 chr10:43711423 RASGEF1A -0.36 -6.39 -0.33 5.51e-10 Hirschsprung disease; LUSC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg02423579 chr7:2872169 GNA12 -0.52 -7.15 -0.36 5.68e-12 Height; LUSC cis rs2404602 0.692 rs35170561 chr15:77130695 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.76 -0.39 1.07e-13 Blood metabolite levels; LUSC cis rs17001868 0.568 rs3788578 chr22:40742921 C/T cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs117352156 0.943 rs7092115 chr10:29220307 C/T cg06394621 chr10:29236369 NA -0.45 -5.91 -0.31 8.29e-9 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs12410462 0.681 rs78978081 chr1:227571619 G/A cg23173402 chr1:227635558 NA 0.56 6.28 0.32 1.07e-9 Major depressive disorder; LUSC cis rs1799949 0.587 rs1824890 chr17:41421904 T/C cg25072359 chr17:41440525 NA 0.62 7.72 0.39 1.38e-13 Menopause (age at onset); LUSC cis rs6469656 1.000 rs13258529 chr8:117797989 G/A cg24004040 chr8:117650383 NA 0.43 5.88 0.31 1.01e-8 Colorectal cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14546197 chr17:38137043 PSMD3 -0.47 -6.1 -0.32 2.94e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC cis rs9399401 0.667 rs12213892 chr6:142702234 A/G cg04461802 chr6:142623433 GPR126 0.47 5.87 0.31 1.06e-8 Chronic obstructive pulmonary disease; LUSC cis rs9788682 0.706 rs2568493 chr15:78740233 G/A cg06917634 chr15:78832804 PSMA4 0.49 6.05 0.31 3.95e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9392556 0.829 rs643232 chr6:4122249 C/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.35 -5.91 -0.31 8.67e-9 Blood metabolite levels; LUSC cis rs4243830 1.000 rs58415361 chr1:6592377 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.94 9.09 0.45 9.12e-18 Body mass index; LUSC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg18252515 chr7:66147081 NA -1.19 -12.75 -0.57 1.35e-30 Diabetic kidney disease; LUSC cis rs2073300 0.609 rs79250740 chr20:23417165 G/A cg09953122 chr20:23471693 CST8 -0.66 -5.76 -0.3 1.95e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1595825 0.945 rs73058818 chr2:198862600 C/T cg10547527 chr2:198650123 BOLL -0.49 -5.82 -0.3 1.35e-8 Ulcerative colitis; LUSC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg22117172 chr7:91764530 CYP51A1 -0.33 -5.93 -0.31 7.65e-9 Breast cancer; LUSC cis rs9467773 1.000 rs10946834 chr6:26533664 G/C cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.86e-18 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs2495745 chr10:102329075 A/G cg07080220 chr10:102295463 HIF1AN 0.65 8.97 0.44 2.25e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs909341 0.678 rs6011018 chr20:62303622 T/G cg16989086 chr20:62203971 PRIC285 -0.53 -7.31 -0.37 1.95e-12 Atopic dermatitis; LUSC cis rs8040855 0.627 rs12913859 chr15:85638418 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.39 -5.7 -0.3 2.68e-8 Bulimia nervosa; LUSC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg19046167 chr17:80928561 B3GNTL1 0.47 7.15 0.36 5.61e-12 Breast cancer; LUSC trans rs35110281 0.626 rs162368 chr21:44934767 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.89 0.44 3.78e-17 Mean corpuscular volume; LUSC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg00074818 chr8:8560427 CLDN23 -0.55 -9.36 -0.46 1.22e-18 Obesity-related traits; LUSC cis rs11105298 0.838 rs4842488 chr12:89881564 C/G cg00757033 chr12:89920650 WDR51B 0.6 10.35 0.49 5.9e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8044995 0.563 rs73613962 chr16:68361974 T/G cg05110241 chr16:68378359 PRMT7 -0.81 -8.76 -0.43 1.02e-16 Schizophrenia; LUSC cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg04455712 chr21:45112962 RRP1B 0.46 8.58 0.43 3.51e-16 Mean corpuscular volume; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg16647868 chr5:131706066 SLC22A5 -0.38 -5.67 -0.3 3.17e-8 Blood metabolite levels; LUSC trans rs62103177 0.564 rs1864529 chr18:77748975 G/A cg05926928 chr17:57297772 GDPD1 -0.91 -10.34 -0.49 6.39e-22 Opioid sensitivity; LUSC cis rs1801251 0.727 rs13029336 chr2:233569935 A/G cg08000102 chr2:233561755 GIGYF2 -0.65 -11.07 -0.52 1.78e-24 Coronary artery disease; LUSC cis rs7267979 1.000 rs2027003 chr20:25350498 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.51 -0.34 2.81e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3862030 0.694 rs1984795 chr10:104226830 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.92 -0.44 3.02e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs965469 1.000 rs6051703 chr20:3252347 A/T cg25506879 chr20:3388711 C20orf194 -0.54 -6.31 -0.33 8.79e-10 IFN-related cytopenia; LUSC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg21433313 chr16:3507492 NAT15 -0.81 -8.94 -0.44 2.7e-17 Tuberculosis; LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -11.98 -0.55 9.35e-28 Platelet count; LUSC cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 6.95 0.36 1.93e-11 Colorectal cancer; LUSC trans rs2727020 0.576 rs12293522 chr11:49558425 T/A cg03929089 chr4:120376271 NA -0.99 -17.65 -0.69 9.8e-50 Coronary artery disease; LUSC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg03806693 chr22:41940476 POLR3H -0.96 -13.04 -0.58 1.08e-31 Vitiligo; LUSC cis rs10504073 0.669 rs341799 chr8:50036574 A/G cg00325661 chr8:49890786 NA 0.59 9.63 0.47 1.56e-19 Blood metabolite ratios; LUSC trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg08975724 chr8:8085496 FLJ10661 -0.45 -6.9 -0.35 2.56e-11 Neuroticism; LUSC cis rs7826238 0.509 rs2948288 chr8:8115304 A/G cg15556689 chr8:8085844 FLJ10661 0.8 13.46 0.59 2.74e-33 Systolic blood pressure; LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg07362569 chr17:61921086 SMARCD2 0.37 7.67 0.39 1.94e-13 Prudent dietary pattern; LUSC cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg15839431 chr19:19639596 YJEFN3 0.66 7.27 0.37 2.65e-12 Bipolar disorder; LUSC cis rs6733011 0.628 rs10188156 chr2:99465875 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.71 -0.3 2.51e-8 Bipolar disorder; LUSC cis rs1113500 0.862 rs2336129 chr1:108640669 A/G cg06207961 chr1:108661230 NA -0.4 -7.51 -0.38 5.44e-13 Growth-regulated protein alpha levels; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg16325326 chr1:53192061 ZYG11B -0.89 -16.48 -0.67 4.45e-45 Monocyte count; LUSC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg11764359 chr7:65958608 NA 0.7 10.7 0.51 3.64e-23 Aortic root size; LUSC cis rs11158026 0.757 rs7159933 chr14:55441641 C/A cg04306507 chr14:55594613 LGALS3 0.38 7.46 0.38 7.57e-13 Parkinson's disease; LUSC cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg23158103 chr7:148848205 ZNF398 -0.49 -7.93 -0.4 3.26e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.81 0.47 3.84e-20 Major depressive disorder; LUSC cis rs3126085 1.000 rs3126092 chr1:152307955 T/A cg26876637 chr1:152193138 HRNR -0.44 -5.7 -0.3 2.68e-8 Atopic dermatitis; LUSC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg01579765 chr21:45077557 HSF2BP -0.57 -12.09 -0.55 3.78e-28 Mean corpuscular volume; LUSC cis rs662064 0.748 rs2480777 chr1:10597551 C/T cg20482658 chr1:10539492 PEX14 0.32 6.45 0.33 3.89e-10 Asthma; LUSC trans rs804280 0.542 rs36100659 chr8:11791653 A/T cg27411982 chr8:10470053 RP1L1 0.4 6.1 0.32 2.91e-9 Myopia (pathological); LUSC trans rs11088226 0.645 rs7281844 chr21:33932435 T/C cg09050820 chr6:167586206 TCP10L2 0.76 9.85 0.47 2.91e-20 Gastritis; LUSC cis rs273573 1.000 rs175398 chr11:30930393 T/G cg06552810 chr11:31128660 NA 0.32 5.69 0.3 2.78e-8 Total body bone mineral density; LUSC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.29 -0.37 2.32e-12 Personality dimensions; LUSC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg14262678 chr6:151773367 RMND1;C6orf211 0.47 7.45 0.38 7.79e-13 Menarche (age at onset); LUSC cis rs2976388 0.647 rs2572898 chr8:143782274 G/C cg17252645 chr8:143867129 LY6D 0.38 6.68 0.34 9.86e-11 Urinary tract infection frequency; LUSC cis rs12519773 0.526 rs7714485 chr5:92515301 A/C cg18783429 chr5:92414398 NA 0.33 7.11 0.36 7.23e-12 Migraine; LUSC cis rs4631830 0.900 rs10763588 chr10:51539762 G/T cg10326726 chr10:51549505 MSMB -0.35 -6.0 -0.31 5.09e-9 Prostate-specific antigen levels; LUSC cis rs6901250 0.523 rs641338 chr6:117086265 C/A cg12892004 chr6:117198278 RFX6 0.34 6.24 0.32 1.3e-9 C-reactive protein levels; LUSC cis rs4285028 0.948 rs12630486 chr3:121685267 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.68 -0.47 1.07e-19 Multiple sclerosis; LUSC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg24733560 chr20:60626293 TAF4 0.44 8.11 0.41 9.46e-15 Body mass index; LUSC cis rs2486288 0.656 rs8041702 chr15:45547093 C/T cg09092052 chr15:45571596 NA 0.47 6.55 0.34 2.22e-10 Glomerular filtration rate; LUSC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs9527 0.590 rs943039 chr10:104825132 C/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.62 -0.34 1.42e-10 Arsenic metabolism; LUSC cis rs7191439 0.674 rs4782429 chr16:88792097 A/G cg27087555 chr16:88793112 FAM38A -1.45 -17.16 -0.68 9.32e-48 Plateletcrit; LUSC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs73206853 0.841 rs73191826 chr12:110943001 G/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 7.83e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs11039798 1.000 rs6485856 chr11:48556298 G/C cg15704280 chr7:45808275 SEPT13 0.69 6.56 0.34 2.06e-10 Axial length; LUSC cis rs2637266 0.783 rs846645 chr10:78516000 A/G cg18941641 chr10:78392320 NA 0.4 7.23 0.37 3.3e-12 Pulmonary function; LUSC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg22143856 chr6:28129313 ZNF389 0.41 5.8 0.3 1.53e-8 Depression; LUSC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg11843238 chr5:131593191 PDLIM4 -0.38 -6.07 -0.32 3.54e-9 Breast cancer; LUSC trans rs62238980 0.522 rs117129307 chr22:32519810 A/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -5.98 -0.31 5.76e-9 Childhood ear infection; LUSC trans rs4714291 0.963 rs847777 chr6:40055754 C/T cg02267698 chr19:7991119 CTXN1 0.53 7.42 0.38 9.76e-13 Strep throat; LUSC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg09365446 chr1:150670422 GOLPH3L -0.46 -6.89 -0.35 2.79e-11 Melanoma; LUSC cis rs12681287 0.517 rs68008113 chr8:87520894 C/A cg27223183 chr8:87520930 FAM82B -0.55 -7.23 -0.37 3.3e-12 Caudate activity during reward; LUSC cis rs2294693 0.947 rs9296351 chr6:40988102 T/C cg14769373 chr6:40998127 UNC5CL -0.54 -8.03 -0.4 1.71e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7903847 0.642 rs1048442 chr10:99160152 A/G cg20016023 chr10:99160130 RRP12 -0.3 -7.47 -0.38 6.85e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs8062405 0.755 rs62034358 chr16:28587597 G/T cg07382826 chr16:28625726 SULT1A1 0.28 5.97 0.31 5.93e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4499344 0.921 rs12973855 chr19:33085395 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.59 -7.54 -0.38 4.59e-13 Mean platelet volume; LUSC cis rs7582180 0.629 rs11682557 chr2:100948008 C/A cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.5e-8 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.710 rs1059306 chr6:86388109 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.69 10.94 0.51 5.25e-24 Response to antipsychotic treatment; LUSC cis rs983392 0.709 rs56273223 chr11:59984676 A/C cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.1e-9 Alzheimer's disease (late onset); LUSC cis rs6089584 0.508 rs6061988 chr20:60626300 C/T cg06108461 chr20:60628389 TAF4 -0.74 -11.89 -0.55 2.01e-27 Body mass index; LUSC cis rs1577917 0.771 rs9353318 chr6:86231721 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 10.74 0.51 2.53e-23 Response to antipsychotic treatment; LUSC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg14004847 chr7:1930337 MAD1L1 -0.62 -10.19 -0.49 2.1e-21 Schizophrenia; LUSC cis rs12701220 0.817 rs7798459 chr7:1087965 C/T cg20821713 chr7:1055600 C7orf50 -0.49 -6.75 -0.35 6.63e-11 Bronchopulmonary dysplasia; LUSC cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg05283184 chr6:79620031 NA -0.57 -12.12 -0.55 2.99e-28 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs6714710 0.603 rs12104810 chr2:98443658 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7432375 0.610 rs60574021 chr3:136520281 C/G cg15507776 chr3:136538369 TMEM22 0.44 7.37 0.37 1.31e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs2067615 0.579 rs1922438 chr12:107085171 C/G cg15890332 chr12:107067104 RFX4 0.33 5.98 0.31 5.83e-9 Heart rate; LUSC cis rs7143963 1.000 rs7153002 chr14:103323915 C/T cg21920469 chr14:103375193 NA -0.45 -5.67 -0.3 3.07e-8 Body mass index; LUSC cis rs17001868 0.568 rs6001894 chr22:40779197 T/C cg07138101 chr22:40742427 ADSL 0.62 7.61 0.38 2.76e-13 Mammographic density (dense area); LUSC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg15147215 chr3:52552868 STAB1 -0.32 -6.3 -0.33 9.32e-10 Electroencephalogram traits; LUSC cis rs7617773 0.817 rs9818937 chr3:48325281 G/A cg11946769 chr3:48343235 NME6 0.86 13.89 0.61 6e-35 Coronary artery disease; LUSC cis rs113835537 0.529 rs57691879 chr11:66236604 C/T cg24851651 chr11:66362959 CCS 0.54 8.27 0.41 3.33e-15 Airway imaging phenotypes; LUSC cis rs6964587 0.900 rs4279 chr7:91764128 C/A cg01689657 chr7:91764605 CYP51A1 0.34 6.09 0.32 3.12e-9 Breast cancer; LUSC cis rs9747201 1.000 rs58472289 chr17:80111895 G/T cg18209359 chr17:80159595 CCDC57 0.38 6.41 0.33 5.03e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs478304 0.654 rs10896032 chr11:65459419 C/A cg27068330 chr11:65405492 SIPA1 -0.75 -10.33 -0.49 7.02e-22 Acne (severe); LUSC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.88 0.58 4.32e-31 Platelet count; LUSC cis rs17270561 0.609 rs9379783 chr6:25725207 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.87 0.44 4.41e-17 Iron status biomarkers; LUSC cis rs911555 0.723 rs4906320 chr14:103876925 T/C cg24130564 chr14:104152367 KLC1 0.45 6.25 0.32 1.25e-9 Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs12704635 chr7:91737324 T/G cg22117172 chr7:91764530 CYP51A1 0.33 5.84 0.3 1.24e-8 Breast cancer; LUSC cis rs6740322 0.748 rs6732337 chr2:43462822 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.52 6.91 0.35 2.53e-11 Coronary artery disease; LUSC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.24e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26695780 chr7:66021476 LOC493754 -0.72 -6.07 -0.32 3.41e-9 Cognitive performance; LUSC cis rs10189230 0.967 rs11692482 chr2:222352405 C/T cg14652038 chr2:222343519 EPHA4 0.32 5.79 0.3 1.66e-8 Urate levels in lean individuals; LUSC cis rs7809950 0.678 rs62483641 chr7:106901741 T/C cg23024343 chr7:107201750 COG5 -0.66 -10.06 -0.48 5.78e-21 Coronary artery disease; LUSC cis rs3743266 0.613 rs12442393 chr15:60734460 C/G cg21667061 chr15:60772094 NARG2 -0.37 -6.13 -0.32 2.55e-9 Menarche (age at onset); LUSC cis rs7072216 0.922 rs4488133 chr10:100159136 A/T cg26618903 chr10:100175079 PYROXD2 0.31 6.18 0.32 1.85e-9 Metabolite levels; LUSC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.21e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs713587 0.967 rs6749422 chr2:25150011 C/G cg04586622 chr2:25135609 ADCY3 0.4 8.29 0.41 2.8e-15 Body mass index in non-asthmatics; LUSC cis rs7582720 1.000 rs115810193 chr2:203943168 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg13736514 chr6:26305472 NA -0.48 -9.49 -0.46 4.46e-19 Educational attainment; LUSC cis rs13108904 0.870 rs2335855 chr4:1237968 T/C cg02018176 chr4:1364513 KIAA1530 0.46 7.74 0.39 1.17e-13 Obesity-related traits; LUSC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2279817 0.780 rs12737453 chr1:18006107 A/C cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.2 -0.32 1.71e-9 Neuroticism; LUSC trans rs11250098 0.574 rs4554431 chr8:10771638 T/A cg15556689 chr8:8085844 FLJ10661 -0.56 -7.91 -0.4 3.77e-14 Morning vs. evening chronotype; LUSC cis rs977987 0.788 rs7184525 chr16:75437186 A/G cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.8e-17 Dupuytren's disease; LUSC cis rs28830936 0.510 rs11070349 chr15:42085017 A/C cg17847044 chr15:42102381 MAPKBP1 -0.37 -9.13 -0.45 6.74e-18 Diastolic blood pressure; LUSC cis rs1775715 0.966 rs1639132 chr10:32301260 G/A cg04359828 chr10:32216031 ARHGAP12 -0.36 -6.08 -0.32 3.27e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs8060686 0.668 rs255056 chr16:68016185 G/C cg05110241 chr16:68378359 PRMT7 -0.54 -6.3 -0.33 9.39e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7296418 0.636 rs11057261 chr12:123797567 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.48 -0.33 3.28e-10 Platelet count; LUSC cis rs6681460 0.649 rs6691033 chr1:67007429 C/T cg02459107 chr1:67143332 SGIP1 0.39 6.56 0.34 2.03e-10 Presence of antiphospholipid antibodies; LUSC cis rs17270561 0.723 rs12213243 chr6:25890108 C/T cg17691542 chr6:26056736 HIST1H1C 0.84 11.25 0.52 4.11e-25 Iron status biomarkers; LUSC cis rs6690583 0.697 rs10873684 chr1:85522196 T/C cg22153463 chr1:85462885 MCOLN2 -0.62 -8.01 -0.4 1.89e-14 Serum sulfate level; LUSC trans rs9929218 0.954 rs2961 chr16:68818903 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -11.19 -0.52 6.92e-25 Colorectal cancer; LUSC cis rs1376877 0.519 rs113217304 chr2:204281120 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.49 6.29 0.33 9.96e-10 Subclinical atherosclerosis traits (other); LUSC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg03233332 chr7:66118400 NA 0.42 5.98 0.31 5.61e-9 Aortic root size; LUSC cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg01884057 chr2:25150051 NA 0.42 9.13 0.45 6.57e-18 Body mass index; LUSC cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.84 -0.3 1.26e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs1979679 0.608 rs4931082 chr12:28720020 G/A cg13890972 chr12:28721907 NA -0.43 -6.04 -0.31 4.05e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC trans rs877282 0.842 rs12357963 chr10:757562 C/T cg22713356 chr15:30763199 NA 1.03 13.61 0.6 7.56e-34 Uric acid levels; LUSC cis rs8078723 0.933 rs55846942 chr17:38164470 G/A cg17467752 chr17:38218738 THRA 0.77 12.45 0.56 1.7e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg14159672 chr1:205819179 PM20D1 -0.78 -14.79 -0.63 2.07e-38 Monocyte percentage of white cells; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg27535305 chr1:53392650 SCP2 -0.41 -8.1 -0.41 1.05e-14 Monocyte count; LUSC cis rs3125734 0.633 rs1368157 chr10:64001114 T/C cg09941381 chr10:64027924 RTKN2 -0.38 -7.04 -0.36 1.11e-11 Rheumatoid arthritis; LUSC cis rs6961069 0.777 rs4545029 chr7:80252518 T/G cg04458919 chr7:80252533 CD36 0.36 6.47 0.33 3.52e-10 Platelet count; LUSC cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14169450 chr9:139327907 INPP5E -0.46 -8.76 -0.43 1.01e-16 Granulocyte percentage of myeloid white cells; LUSC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg22875332 chr1:76189707 ACADM 0.81 14.53 0.62 2.1e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7772486 0.875 rs2073287 chr6:146350264 T/C cg05347473 chr6:146136440 FBXO30 0.5 8.39 0.42 1.35e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs870825 0.616 rs56232457 chr4:185628153 T/G cg04058563 chr4:185651563 MLF1IP 0.88 13.27 0.59 1.4e-32 Blood protein levels; LUSC cis rs73206853 0.841 rs56324794 chr12:111086449 T/A cg12870014 chr12:110450643 ANKRD13A 0.7 7.29 0.37 2.21e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg01879757 chr17:41196368 BRCA1 0.46 6.96 0.36 1.77e-11 Menopause (age at onset); LUSC cis rs3960554 0.733 rs59170362 chr7:75629267 G/C cg17325771 chr7:75508891 RHBDD2 -0.4 -5.79 -0.3 1.66e-8 Eotaxin levels; LUSC cis rs7177699 0.557 rs7403593 chr15:79111962 A/G cg00540400 chr15:79124168 NA -0.48 -8.43 -0.42 1.04e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9473147 0.516 rs10948363 chr6:47487762 A/G cg20196966 chr6:47445060 CD2AP 0.41 5.79 0.3 1.66e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs1801251 1.000 rs10933412 chr2:233707226 G/C cg08000102 chr2:233561755 GIGYF2 -0.69 -11.44 -0.53 8.87e-26 Coronary artery disease; LUSC cis rs7503807 0.967 rs9915162 chr17:78614326 T/C cg09596252 chr17:78655493 RPTOR 0.44 7.53 0.38 4.77e-13 Obesity; LUSC cis rs3540 0.574 rs2657947 chr15:90968977 C/T cg04176472 chr15:90893244 GABARAPL3 -0.34 -6.19 -0.32 1.8e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs9902453 0.817 rs62068625 chr17:28176581 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.63 0.47 1.5700000000000001e-19 Coffee consumption (cups per day); LUSC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.67e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11785400 1.000 rs11776301 chr8:143737142 A/G cg10596483 chr8:143751796 JRK 0.61 9.31 0.45 1.73e-18 Schizophrenia; LUSC cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -11.11 -0.52 1.25e-24 Chronic sinus infection; LUSC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg21918786 chr6:109611834 NA -0.42 -7.28 -0.37 2.36e-12 Reticulocyte fraction of red cells; LUSC cis rs6977660 0.714 rs6945753 chr7:19814255 A/G cg05791153 chr7:19748676 TWISTNB 0.7 7.45 0.38 8.29e-13 Thyroid stimulating hormone; LUSC cis rs4964805 0.657 rs11111783 chr12:104188523 A/G cg02344784 chr12:104178138 NT5DC3 0.46 8.9 0.44 3.59e-17 Attention deficit hyperactivity disorder; LUSC cis rs17095355 0.818 rs61881638 chr10:111863396 C/G cg00817464 chr10:111662876 XPNPEP1 -0.59 -6.84 -0.35 3.69e-11 Biliary atresia; LUSC cis rs870825 0.929 rs72689265 chr4:185590982 A/G cg04058563 chr4:185651563 MLF1IP 0.83 11.29 0.53 2.87e-25 Blood protein levels; LUSC cis rs9389248 0.690 rs2072826 chr6:135253558 G/C cg22676075 chr6:135203613 NA -0.65 -10.27 -0.49 1.13e-21 High light scatter reticulocyte percentage of red cells; LUSC cis rs7666738 0.546 rs10010088 chr4:98655945 C/T cg03676636 chr4:99064102 C4orf37 0.3 6.03 0.31 4.28e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg06618935 chr21:46677482 NA -0.34 -6.53 -0.34 2.49e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3857536 0.813 rs2040594 chr6:66943966 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.04 -0.31 4.02e-9 Blood trace element (Cu levels); LUSC trans rs11098499 0.954 rs10005644 chr4:120298477 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC trans rs9409565 0.586 rs9409547 chr9:97212196 A/C cg05679027 chr9:99775184 HIATL2 -0.46 -6.05 -0.31 3.78e-9 Colorectal cancer (alcohol consumption interaction); LUSC cis rs155346 1.000 rs265148 chr5:139400779 T/C cg01090482 chr5:139365336 NRG2 -0.36 -5.93 -0.31 7.65e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg05025164 chr4:1340916 KIAA1530 -0.5 -7.63 -0.39 2.52e-13 Obesity-related traits; LUSC cis rs4721295 0.546 rs1637766 chr7:2204400 G/A cg21782813 chr7:2030301 MAD1L1 -0.38 -6.35 -0.33 7.12e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg20573242 chr4:122745356 CCNA2 0.44 6.77 0.35 5.65e-11 Type 2 diabetes; LUSC cis rs911186 0.730 rs2393911 chr6:27057079 C/T cg05738196 chr6:26577821 NA -0.46 -5.76 -0.3 1.88e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg01943577 chr7:158741284 NA -0.4 -5.7 -0.3 2.58e-8 Height; LUSC trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg03929089 chr4:120376271 NA -0.6 -7.24 -0.37 3.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg03806693 chr22:41940476 POLR3H -1.05 -15.24 -0.64 3.49e-40 Vitiligo; LUSC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg21699342 chr2:239360505 ASB1 0.58 10.75 0.51 2.47e-23 Multiple system atrophy; LUSC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs8058578 1.000 rs7198250 chr16:30746822 C/A cg05768032 chr16:30646687 NA 0.4 5.92 0.31 7.93e-9 Multiple myeloma; LUSC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.59 -0.38 3.13e-13 Intelligence (multi-trait analysis); LUSC cis rs9314323 0.729 rs7007256 chr8:26203081 G/A cg13160058 chr8:26243215 BNIP3L -0.37 -6.56 -0.34 2.02e-10 Red cell distribution width; LUSC cis rs860295 0.812 rs10908481 chr1:155713650 T/G cg08949192 chr1:155289623 RUSC1;FDPS -0.34 -5.75 -0.3 2.03e-8 Body mass index; LUSC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.39 6.16 0.32 2.06e-9 Cognitive test performance; LUSC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg13531842 chr10:38383804 ZNF37A -0.46 -7.19 -0.37 4.35e-12 Extrinsic epigenetic age acceleration; LUSC cis rs11098499 0.575 rs907204 chr4:120238654 G/A cg09307838 chr4:120376055 NA 0.69 10.51 0.5 1.65e-22 Corneal astigmatism; LUSC cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg24642439 chr20:33292090 TP53INP2 0.5 7.5 0.38 5.67e-13 Glomerular filtration rate (creatinine); LUSC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg24642844 chr7:1081250 C7orf50 -0.69 -9.84 -0.47 3.18e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2406342 0.528 rs75536638 chr18:74499060 G/T cg14129931 chr18:74513950 NA 0.43 6.24 0.32 1.35e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); LUSC cis rs7561273 0.609 rs10197527 chr2:24352398 A/C cg06627628 chr2:24431161 ITSN2 -0.52 -6.99 -0.36 1.55e-11 Quantitative traits; LUSC cis rs10504073 0.647 rs10105794 chr8:50012793 G/C cg00325661 chr8:49890786 NA 0.63 10.7 0.51 3.73e-23 Blood metabolite ratios; LUSC cis rs9796 0.870 rs2925342 chr15:41305733 A/G cg18705301 chr15:41695430 NDUFAF1 0.45 7.88 0.4 4.51e-14 Menopause (age at onset); LUSC cis rs11208691 0.513 rs10443260 chr1:66128866 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 Lymphocyte percentage of white cells; LUSC trans rs10435719 0.899 rs9329251 chr8:11793606 G/A cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.77e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg05729581 chr11:3078854 CARS -0.56 -8.5 -0.42 6.4e-16 Longevity; LUSC cis rs11098499 0.532 rs4833624 chr4:120585497 C/T cg09307838 chr4:120376055 NA 0.67 9.35 0.46 1.28e-18 Corneal astigmatism; LUSC cis rs3540 0.553 rs2158406 chr15:90994499 T/C cg10434728 chr15:90938212 IQGAP1 0.43 8.66 0.43 1.98e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs2797160 1.000 rs1739375 chr6:126012013 T/C cg05039488 chr6:79577232 IRAK1BP1 0.44 6.6 0.34 1.66e-10 Endometrial cancer; LUSC cis rs12220238 1.000 rs7907801 chr10:75976638 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.12e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs6831352 0.819 rs896992 chr4:100002372 C/T cg13256891 chr4:100009986 ADH5 0.42 5.98 0.31 5.85e-9 Alcohol dependence; LUSC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg14552801 chr7:65878734 NA 0.45 6.53 0.34 2.5e-10 Aortic root size; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg14159672 chr1:205819179 PM20D1 0.94 18.97 0.72 5.91e-55 Menarche (age at onset); LUSC cis rs2439831 0.681 rs956391 chr15:43617493 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.96 -13.16 -0.58 3.9e-32 Lung cancer in ever smokers; LUSC cis rs9467711 0.523 rs9379853 chr6:26357635 A/G cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs11748023 0.531 rs155947 chr5:139520556 C/T cg26211634 chr5:139558579 C5orf32 0.34 6.17 0.32 2e-9 Intelligence (multi-trait analysis); LUSC cis rs672059 1.000 rs1760624 chr1:183158552 C/A ch.1.3577855R chr1:183094577 LAMC1 0.54 7.98 0.4 2.42e-14 Hypertriglyceridemia; LUSC cis rs2840044 0.534 rs167691 chr17:33885826 G/A cg05299278 chr17:33885742 SLFN14 0.34 7.77 0.39 9.6e-14 Response to radiotherapy in cancer (late toxicity); LUSC cis rs9815354 0.812 rs113772069 chr3:41933389 T/C cg03022575 chr3:42003672 ULK4 0.82 8.55 0.42 4.49e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg22508957 chr16:3507546 NAT15 0.68 11.08 0.52 1.69e-24 Tuberculosis; LUSC cis rs2479724 0.935 rs7753507 chr6:41784094 C/T cg17623882 chr6:41773611 USP49 0.61 10.1 0.48 4.13e-21 Menarche (age at onset); LUSC cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg04756594 chr16:24857601 SLC5A11 -0.38 -6.34 -0.33 7.66e-10 Intelligence (multi-trait analysis); LUSC cis rs4285028 0.747 rs3732407 chr3:121416623 G/C cg11130432 chr3:121712080 ILDR1 -0.59 -8.53 -0.42 5.25e-16 Multiple sclerosis; LUSC cis rs2404602 0.655 rs8028294 chr15:77084877 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.64 -0.39 2.3e-13 Blood metabolite levels; LUSC cis rs2635047 0.530 rs4986228 chr18:44595259 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.2 0.32 1.68e-9 Educational attainment; LUSC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg24562669 chr7:97807699 LMTK2 0.35 6.06 0.31 3.63e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3760982 1.000 rs3760983 chr19:44286660 C/T cg11993925 chr19:44307056 LYPD5 -0.28 -6.2 -0.32 1.65e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.06 -0.48 5.7e-21 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7582180 0.663 rs930374 chr2:100962700 A/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.61 -0.43 2.9e-16 Intelligence (multi-trait analysis); LUSC trans rs17150703 0.630 rs12545481 chr8:9747377 G/A cg06636001 chr8:8085503 FLJ10661 0.51 6.41 0.33 4.89e-10 Obesity (early onset extreme); LUSC cis rs1808579 0.904 rs1618725 chr18:21126952 C/T cg14672496 chr18:21087552 C18orf8 0.37 6.54 0.34 2.34e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg07777115 chr5:623756 CEP72 -0.46 -5.93 -0.31 7.72e-9 Obesity-related traits; LUSC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.56e-11 Total body bone mineral density; LUSC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg23719950 chr11:63933701 MACROD1 -0.63 -8.13 -0.41 8.2e-15 Mean platelet volume; LUSC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg09904177 chr6:26538194 HMGN4 0.42 6.14 0.32 2.41e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7582180 0.700 rs11685401 chr2:100976685 A/G cg12002119 chr2:101014098 CHST10 0.36 6.13 0.32 2.41e-9 Intelligence (multi-trait analysis); LUSC cis rs8141529 0.871 rs5762877 chr22:29277555 G/A cg15103426 chr22:29168792 CCDC117 0.53 6.47 0.33 3.54e-10 Lymphocyte counts; LUSC trans rs7951105 0.737 rs976909 chr11:39247793 C/G cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08109568 chr15:31115862 NA 0.48 6.64 0.34 1.3e-10 Huntington's disease progression; LUSC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.75 -7.22 -0.37 3.53e-12 Cerebrospinal P-tau181p levels; LUSC trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -8.09 -0.4 1.15e-14 Triglycerides; LUSC cis rs9463078 0.506 rs4714820 chr6:44736737 T/A cg25276700 chr6:44698697 NA 0.3 6.3 0.33 9.28e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs11677416 1.000 rs2856837 chr2:113541925 G/A cg27083787 chr2:113543245 IL1A 0.47 7.39 0.37 1.17e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08109568 chr15:31115862 NA -0.59 -8.22 -0.41 4.55e-15 Huntington's disease progression; LUSC cis rs10266483 0.774 rs642909 chr7:63770321 T/C cg24201672 chr7:64023550 ZNF680 -0.47 -5.93 -0.31 7.74e-9 Response to statin therapy; LUSC cis rs9479482 1.000 rs11155696 chr6:150357283 G/A cg00432049 chr6:150390894 ULBP3 -0.27 -5.7 -0.3 2.7e-8 Alopecia areata; LUSC cis rs9309473 0.607 rs58962779 chr2:73555801 T/C cg20560298 chr2:73613845 ALMS1 -0.54 -8.24 -0.41 4.1e-15 Metabolite levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05787193 chr1:84543369 PRKACB -0.41 -6.46 -0.33 3.8e-10 Electrocardiographic conduction measures; LUSC cis rs240764 0.658 rs9322212 chr6:101248474 T/C cg09795085 chr6:101329169 ASCC3 -0.46 -6.65 -0.34 1.18e-10 Neuroticism; LUSC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg25282410 chr6:160211355 TCP1;MRPL18 1.13 17.23 0.69 4.9e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs2997447 0.846 rs3008419 chr1:26402820 A/C cg19633962 chr1:26362018 EXTL1 -0.49 -5.76 -0.3 1.92e-8 QRS complex (12-leadsum); LUSC cis rs72781680 0.898 rs2339851 chr2:23938883 G/A cg20701182 chr2:24300061 SF3B14 0.74 7.33 0.37 1.77e-12 Lymphocyte counts; LUSC cis rs8072100 0.713 rs8074451 chr17:45477573 C/T cg08085267 chr17:45401833 C17orf57 -0.46 -6.54 -0.34 2.3e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2112347 0.502 rs34339 chr5:74931333 G/T cg19683494 chr5:74908142 NA -0.57 -7.06 -0.36 9.82e-12 Body mass index (joint analysis main effects and smoking interaction);Waist circumference;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Hip circumference;Body mass index;Body mass index in physically active individuals;Obesity; LUSC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs71403859 0.730 rs17355804 chr16:71717214 A/G cg08717414 chr16:71523259 ZNF19 -0.65 -7.28 -0.37 2.47e-12 Post bronchodilator FEV1; LUSC cis rs7617480 0.585 rs7373072 chr3:48960017 T/A cg07636037 chr3:49044803 WDR6 0.93 12.86 0.58 5.16e-31 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs12458462 0.892 rs35928863 chr18:77438956 A/G cg11879182 chr18:77439856 CTDP1 0.72 11.91 0.55 1.68e-27 Monocyte count; LUSC cis rs7264396 0.676 rs1341603 chr20:34556216 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC trans rs61931739 0.534 rs11053014 chr12:34103519 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs7760535 0.597 rs9320368 chr6:111904737 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.44 -8.73 -0.43 1.23e-16 Metabolic traits; LUSC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg10523679 chr1:76189770 ACADM 0.89 15.83 0.65 1.73e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7582180 0.629 rs11686880 chr2:100956229 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.82 0.3 1.4e-8 Intelligence (multi-trait analysis); LUSC cis rs738322 0.511 rs2267371 chr22:38577119 T/G cg25457927 chr22:38595422 NA -0.37 -7.11 -0.36 6.88e-12 Cutaneous nevi; LUSC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.37 -0.42 1.58e-15 Platelet count; LUSC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg08219700 chr8:58056026 NA 0.45 5.84 0.3 1.24e-8 Developmental language disorder (linguistic errors); LUSC cis rs59104589 0.617 rs16843671 chr2:242374358 T/C cg14842376 chr2:242211374 HDLBP 0.53 6.1 0.32 2.97e-9 Fibrinogen levels; LUSC cis rs12472274 0.529 rs11677996 chr2:239118007 A/G cg17459225 chr2:239074497 NA 0.54 7.32 0.37 1.82e-12 Phospholipid levels (plasma); LUSC cis rs7223966 1.000 rs7222060 chr17:61868279 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.9 0.35 2.56e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg02018176 chr4:1364513 KIAA1530 0.45 7.71 0.39 1.42e-13 Obesity-related traits; LUSC cis rs7923609 0.740 rs10761784 chr10:65308750 A/T cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.27e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs2239547 0.522 rs2581815 chr3:52982159 C/G cg18404041 chr3:52824283 ITIH1 -0.53 -9.01 -0.44 1.63e-17 Schizophrenia; LUSC cis rs72717009 0.825 rs867624 chr1:161467837 A/T cg23840854 chr1:161414152 NA -0.9 -11.46 -0.53 7e-26 Rheumatoid arthritis; LUSC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg07395648 chr5:131743802 NA -0.43 -7.25 -0.37 2.94e-12 Blood metabolite levels; LUSC trans rs853679 0.882 rs9366717 chr6:28191057 C/T cg01620082 chr3:125678407 NA -0.59 -6.38 -0.33 5.96e-10 Depression; LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg15147215 chr3:52552868 STAB1 -0.35 -6.96 -0.36 1.86e-11 Bipolar disorder; LUSC cis rs3106136 0.967 rs11097409 chr4:95168515 C/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.11 -0.32 2.76e-9 Capecitabine sensitivity; LUSC cis rs9287719 0.674 rs11691060 chr2:10827061 T/C cg02196655 chr2:10830764 NOL10 0.34 5.79 0.3 1.64e-8 Prostate cancer; LUSC cis rs4969178 0.896 rs1976704 chr17:76401318 C/T cg20026190 chr17:76395443 PGS1 0.46 8.13 0.41 8.42e-15 HDL cholesterol levels; LUSC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg04865166 chr7:105162814 PUS7 0.51 5.71 0.3 2.49e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6582630 0.533 rs2120464 chr12:38280289 A/C cg13010199 chr12:38710504 ALG10B 0.47 7.03 0.36 1.14e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg05347473 chr6:146136440 FBXO30 0.44 7.57 0.38 3.75e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7804356 0.813 rs76438067 chr7:26911904 C/T cg03456212 chr7:26904342 SKAP2 -0.6 -6.68 -0.34 9.83e-11 Type 1 diabetes; LUSC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.54 9.08 0.44 9.91e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg23630131 chr7:65973040 NA 0.2 5.73 0.3 2.29e-8 Aortic root size; LUSC cis rs6121246 0.529 rs6120862 chr20:30199459 T/C cg18721089 chr20:30220636 NA -0.37 -5.76 -0.3 1.86e-8 Mean corpuscular hemoglobin; LUSC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg20818283 chr2:191399100 TMEM194B 0.45 6.98 0.36 1.58e-11 Pulse pressure; LUSC cis rs7827545 1.000 rs6578232 chr8:135565690 G/A cg17885191 chr8:135476712 NA 0.56 8.35 0.42 1.87e-15 Hypertension (SNP x SNP interaction); LUSC cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg15395560 chr15:45543142 SLC28A2 0.34 5.9 0.31 9.13e-9 Uric acid levels; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.89 -0.31 9.55e-9 Platelet count; LUSC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg22105103 chr4:187893119 NA 0.7 13.16 0.58 3.88e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg22549504 chr19:17448937 GTPBP3 0.55 7.06 0.36 9.83e-12 Systemic lupus erythematosus; LUSC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00930347 chr6:110012366 AKD1;FIG4 0.37 6.01 0.31 4.77e-9 Triglycerides; LUSC cis rs6681460 0.966 rs4655646 chr1:67094336 G/A cg02459107 chr1:67143332 SGIP1 0.46 8.54 0.42 4.73e-16 Presence of antiphospholipid antibodies; LUSC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg19592336 chr6:28129416 ZNF389 0.51 6.58 0.34 1.8e-10 Parkinson's disease; LUSC cis rs644148 0.693 rs2686772 chr19:44999729 T/C cg15540054 chr19:45004280 ZNF180 -0.55 -7.79 -0.39 8.35e-14 Personality dimensions; LUSC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg13319975 chr6:146136371 FBXO30 0.51 7.64 0.39 2.31e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg18225595 chr11:63971243 STIP1 -0.46 -5.92 -0.31 8.04e-9 Mean platelet volume; LUSC cis rs7122539 0.646 rs608248 chr11:66562248 C/T cg24851651 chr11:66362959 CCS -0.54 -9.7 -0.47 9.09e-20 HIV-1 susceptibility; LUSC trans rs7849782 0.664 rs1407875 chr9:104391744 A/G cg22914338 chr19:14376960 NA 0.26 6.41 0.33 4.87e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs3008870 0.755 rs10749766 chr1:67376921 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.48 0.56 1.31e-29 Lymphocyte percentage of white cells; LUSC cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg23711669 chr6:146136114 FBXO30 0.9 16.97 0.68 5.1e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.37 5.65 0.3 3.5e-8 Menarche (age at onset); LUSC cis rs7572644 0.699 rs1841068 chr2:28191629 C/T cg27432699 chr2:27873401 GPN1 -0.52 -7.01 -0.36 1.34e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2014572 0.967 rs10411941 chr19:57762886 C/T cg24459738 chr19:57751996 ZNF805 -0.51 -7.53 -0.38 4.85e-13 Hyperactive-impulsive symptoms; LUSC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg01503450 chr10:980765 NA -0.38 -5.7 -0.3 2.68e-8 Eosinophil percentage of granulocytes; LUSC cis rs12986413 1.000 rs11882273 chr19:2173836 T/C cg09261902 chr19:2140048 AP3D1 0.31 5.93 0.31 7.5e-9 Height; LUSC cis rs7771547 0.642 rs628213 chr6:36508646 T/C cg07856975 chr6:36356162 ETV7 0.37 6.49 0.33 3.18e-10 Platelet distribution width; LUSC cis rs10203711 0.901 rs907101 chr2:239564458 T/A cg14580085 chr2:239553406 NA 0.4 6.95 0.36 1.95e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs314370 1.000 rs12705089 chr7:100465355 C/T cg08558340 chr7:100472263 SRRT 0.51 6.33 0.33 8.05e-10 Resting heart rate; LUSC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg15744005 chr10:104629667 AS3MT 0.31 6.51 0.34 2.77e-10 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg07701084 chr6:150067640 NUP43 0.56 8.63 0.43 2.49e-16 Lung cancer; LUSC cis rs7179456 0.557 rs446126 chr15:59113102 A/G cg05156742 chr15:59063176 FAM63B 0.55 8.57 0.42 3.76e-16 Asperger disorder; LUSC cis rs6964587 0.967 rs12535601 chr7:91718346 A/G cg17063962 chr7:91808500 NA 0.59 9.25 0.45 2.65e-18 Breast cancer; LUSC trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg21153622 chr11:89784906 NA -0.39 -6.0 -0.31 5.21e-9 HDL cholesterol; LUSC cis rs11822910 0.911 rs61886978 chr11:57194848 G/C cg00522883 chr11:57194120 SLC43A3 0.43 6.95 0.36 1.9e-11 Platelet distribution width; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg02353165 chr6:42928485 GNMT 0.7 11.99 0.55 8.93e-28 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg12310025 chr6:25882481 NA -0.5 -8.97 -0.44 2.17e-17 Blood metabolite levels; LUSC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.38 -5.99 -0.31 5.32e-9 Alzheimer's disease (late onset); LUSC cis rs17572109 0.666 rs4674297 chr2:219229147 A/G cg00012203 chr2:219082015 ARPC2 0.45 5.84 0.3 1.23e-8 Platelet count;Platelet distribution width;Mean platelet volume; LUSC cis rs7267979 1.000 rs6037121 chr20:25428311 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg02269571 chr22:50332266 NA -0.55 -8.22 -0.41 4.65e-15 Schizophrenia; LUSC cis rs62400317 0.859 rs10948214 chr6:45170466 T/C cg18551225 chr6:44695536 NA -0.45 -7.42 -0.38 9.52e-13 Total body bone mineral density; LUSC cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.74 -0.3 2.09e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs909674 0.734 rs1005522 chr22:39845898 C/A cg11247378 chr22:39784982 NA -0.57 -9.33 -0.45 1.51e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs61931739 0.517 rs11513519 chr12:34075077 G/A cg06521331 chr12:34319734 NA -0.47 -7.63 -0.39 2.47e-13 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs9300255 0.722 rs10773008 chr12:123800820 A/G cg00376283 chr12:123451042 ABCB9 0.66 7.74 0.39 1.2e-13 Neutrophil percentage of white cells; LUSC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg17724175 chr1:150552817 MCL1 0.37 6.78 0.35 5.38e-11 Tonsillectomy; LUSC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg22968622 chr17:43663579 NA 0.77 11.94 0.55 1.35e-27 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2742417 0.967 rs2742419 chr3:45731929 G/A cg09608765 chr3:45636137 LIMD1 -0.37 -7.21 -0.37 3.68e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.48 0.38 6.76e-13 Alzheimer's disease; LUSC cis rs6500602 0.647 rs3747600 chr16:4586222 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.53 7.43 0.38 8.98e-13 Schizophrenia; LUSC trans rs853679 0.599 rs149949 chr6:28011516 T/C cg06606381 chr12:133084897 FBRSL1 -0.64 -7.23 -0.37 3.28e-12 Depression; LUSC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg04352962 chr1:209979756 IRF6 0.5 6.74 0.35 7.02e-11 Cleft lip with or without cleft palate; LUSC cis rs6089584 0.526 rs6089619 chr20:60610916 C/T cg06108461 chr20:60628389 TAF4 -0.74 -12.29 -0.56 6.68e-29 Body mass index; LUSC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg12365402 chr11:9010492 NRIP3 -0.49 -9.43 -0.46 7.35e-19 Hemoglobin concentration; LUSC cis rs35883536 0.647 rs55728953 chr1:101046863 T/C cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.35 -0.46 1.28e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.46 6.13 0.32 2.45e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs61931739 0.500 rs7484658 chr12:34515879 A/G cg06521331 chr12:34319734 NA -0.41 -6.8 -0.35 4.96e-11 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg11494091 chr17:61959527 GH2 0.64 13.71 0.6 2.98e-34 Prudent dietary pattern; LUSC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg03709012 chr19:19516395 GATAD2A 0.67 9.51 0.46 3.78e-19 Tonsillectomy; LUSC cis rs9399135 1.000 rs6569988 chr6:135352303 C/A cg22676075 chr6:135203613 NA 0.48 7.5 0.38 5.76e-13 Red blood cell count; LUSC cis rs7586673 0.964 rs34444368 chr2:161954217 G/A cg22496339 chr2:162101262 NA 0.5 7.18 0.37 4.47e-12 Intelligence (multi-trait analysis); LUSC cis rs1950626 0.833 rs35151884 chr14:101394196 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.08 0.36 8.68e-12 Pelvic organ prolapse (moderate/severe); LUSC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC trans rs3733585 0.664 rs28602527 chr4:9958327 G/A cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs10493773 0.502 rs12066742 chr1:86081149 A/G cg17807903 chr1:86174739 ZNHIT6 -0.39 -8.23 -0.41 4.21e-15 Urate levels in overweight individuals; LUSC cis rs2273669 0.667 rs11153148 chr6:109304084 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.19 -0.32 1.76e-9 Prostate cancer; LUSC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg01570182 chr17:44337453 NA 0.62 9.3 0.45 1.83e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10791097 0.694 rs4264159 chr11:130755784 G/T cg12179176 chr11:130786555 SNX19 0.85 14.78 0.63 2.24e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7100689 0.753 rs1361458 chr10:82090339 A/T cg00277334 chr10:82204260 NA -0.55 -7.69 -0.39 1.69e-13 Post bronchodilator FEV1; LUSC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg18135555 chr8:22132992 PIWIL2 0.39 8.06 0.4 1.33e-14 Hypertriglyceridemia; LUSC cis rs10992471 0.603 rs4744141 chr9:95352140 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.75 -0.35 6.38e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg03676636 chr4:99064102 C4orf37 0.35 6.37 0.33 6.18e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg02527881 chr3:46936655 PTH1R 0.34 6.07 0.32 3.45e-9 Colorectal cancer; LUSC cis rs977987 0.843 rs11644741 chr16:75466433 C/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.4e-11 Dupuytren's disease; LUSC cis rs714027 0.585 rs41171 chr22:30422107 C/G cg11564601 chr22:30592435 NA -0.36 -6.15 -0.32 2.17e-9 Lymphocyte counts; LUSC cis rs1577917 0.518 rs2475787 chr6:86415236 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.51 7.96 0.4 2.78e-14 Response to antipsychotic treatment; LUSC cis rs1595825 0.891 rs77706948 chr2:198608441 T/G cg19156104 chr2:198669113 PLCL1 -0.48 -5.83 -0.3 1.29e-8 Ulcerative colitis; LUSC cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg08085267 chr17:45401833 C17orf57 -0.6 -9.93 -0.48 1.6e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02952711 chr10:134145586 LRRC27 -0.44 -6.49 -0.33 3.03e-10 Electrocardiographic conduction measures; LUSC cis rs4891159 0.790 rs11872411 chr18:74132051 C/T cg24786174 chr18:74118243 ZNF516 -0.83 -15.21 -0.64 4.41e-40 Longevity; LUSC cis rs7267979 1.000 rs6107046 chr20:25442049 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.22 0.71 5.32e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7605827 0.930 rs722327 chr2:15657263 T/A cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.48 0.33 3.33e-10 Lung cancer; LUSC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg14552801 chr7:65878734 NA -0.45 -6.54 -0.34 2.33e-10 Aortic root size; LUSC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg00857998 chr1:205179979 DSTYK 0.64 9.81 0.47 4.01e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC trans rs6841433 0.615 rs13147106 chr4:115473362 T/C cg01865118 chr8:29204221 DUSP4 -0.51 -5.97 -0.31 5.93e-9 Hemoglobin concentration; LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg00149659 chr3:10157352 C3orf10 0.9 11.67 0.54 1.28e-26 Alzheimer's disease; LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.63 0.5 6.31e-23 Menopause (age at onset); LUSC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.61e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7590368 0.961 rs13431852 chr2:10960410 T/C cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC trans rs11764590 0.715 rs56289396 chr7:2091415 G/A cg25206134 chr2:45395956 NA 0.56 6.14 0.32 2.38e-9 Neuroticism; LUSC cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.51e-15 Axial length; LUSC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -5.86 -0.31 1.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs9318086 0.901 rs7336730 chr13:24452104 T/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.39 -5.93 -0.31 7.54e-9 Myopia (pathological); LUSC cis rs7267979 0.903 rs2500423 chr20:25374882 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.57 -0.69 2.11e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.28e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs4363385 0.626 rs11205179 chr1:153021399 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -6.03 -0.31 4.41e-9 Inflammatory skin disease; LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg18402987 chr7:1209562 NA 0.73 7.85 0.39 5.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg27129171 chr3:47204927 SETD2 0.66 11.09 0.52 1.47e-24 Colorectal cancer; LUSC trans rs853679 0.517 rs9368550 chr6:28051803 T/A cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC trans rs7178375 1.000 rs7178375 chr15:31215935 C/T cg04373760 chr16:53404718 NA 0.65 8.8 0.43 7.59e-17 Hypertriglyceridemia; LUSC cis rs7615316 0.934 rs9683085 chr3:142248498 G/A cg16271453 chr3:142027066 XRN1 -0.4 -6.83 -0.35 3.93e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.4e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs9291683 0.575 rs3756223 chr4:10105797 C/T cg26043149 chr18:55253948 FECH 0.48 7.31 0.37 2.04e-12 Bone mineral density; LUSC trans rs7615952 0.641 rs61048217 chr3:125807905 G/T cg07211511 chr3:129823064 LOC729375 -0.75 -9.68 -0.47 1.1e-19 Blood pressure (smoking interaction); LUSC cis rs59698941 0.943 rs17691584 chr5:132284251 A/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.53 -0.34 2.52e-10 Apolipoprotein A-IV levels; LUSC cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Bone mineral density; LUSC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11644478 chr21:40555479 PSMG1 -0.66 -10.26 -0.49 1.21e-21 Menarche (age at onset); LUSC trans rs7726839 0.540 rs7434 chr5:660804 A/G cg08313168 chr12:7315531 NA -0.46 -5.98 -0.31 5.67e-9 Obesity-related traits; LUSC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg03354898 chr7:1950403 MAD1L1 -0.38 -7.18 -0.37 4.63e-12 Bipolar disorder and schizophrenia; LUSC cis rs9457247 0.905 rs444210 chr6:167390242 A/G cg20406979 chr6:167373233 NA 0.27 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs10788264 0.621 rs7907952 chr10:124056774 C/T cg09507567 chr10:124027408 NA -0.44 -7.47 -0.38 7.3e-13 Total body bone mineral density; LUSC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg16624210 chr5:671434 TPPP 0.49 6.05 0.31 3.83e-9 Lung disease severity in cystic fibrosis; LUSC cis rs2046867 0.818 rs62249863 chr3:72868666 G/C cg25664220 chr3:72788482 NA -0.71 -11.9 -0.55 1.87e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9648716 0.515 rs38720 chr7:140694458 A/T cg23214464 chr7:140373596 ADCK2 0.74 6.33 0.33 8.04e-10 Type 2 diabetes; LUSC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11677416 1.000 rs3783520 chr2:113544339 C/T cg27083787 chr2:113543245 IL1A 0.47 7.35 0.37 1.56e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC trans rs683250 1.000 rs505621 chr11:83277927 A/G cg26617787 chr11:123396133 GRAMD1B -0.32 -6.13 -0.32 2.46e-9 Subcortical brain region volumes; LUSC cis rs11098499 0.954 rs7656252 chr4:120404268 T/C cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.57e-25 Corneal astigmatism; LUSC cis rs9462027 0.583 rs11755420 chr6:34760956 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg17971929 chr21:40555470 PSMG1 -0.48 -7.2 -0.37 4.1e-12 Menarche (age at onset); LUSC cis rs3008870 0.883 rs2755249 chr1:67493662 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.96 15.46 0.65 4.83e-41 Lymphocyte percentage of white cells; LUSC cis rs61990749 0.597 rs11624101 chr14:78138059 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.6 -6.43 -0.33 4.5e-10 Fibroblast growth factor basic levels; LUSC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg06873352 chr17:61820015 STRADA 0.56 8.68 0.43 1.83e-16 Height; LUSC cis rs3820068 0.580 rs61169376 chr1:16003832 A/G cg17385448 chr1:15911702 AGMAT 0.36 5.98 0.31 5.86e-9 Systolic blood pressure; LUSC cis rs12200782 1.000 rs72844495 chr6:26610640 T/C cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs968451 1.000 rs968451 chr22:39670851 G/T cg17798944 chr22:39715225 SNORD43;RPL3 0.72 9.02 0.44 1.5e-17 Primary biliary cholangitis; LUSC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg21782813 chr7:2030301 MAD1L1 0.46 7.62 0.38 2.72e-13 Schizophrenia; LUSC cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg26384229 chr12:38710491 ALG10B 0.84 13.92 0.61 4.87e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs12928939 0.954 rs8057568 chr16:71811995 G/A cg03805757 chr16:71968109 PKD1L3 -0.46 -6.71 -0.34 8.33e-11 Post bronchodilator FEV1; LUSC cis rs944990 0.538 rs10821123 chr9:96169561 G/A cg13717394 chr9:96054313 WNK2 -0.37 -5.99 -0.31 5.3e-9 Body mass index; LUSC cis rs79349575 0.749 rs12601672 chr17:47006493 T/C cg22482690 chr17:47019901 SNF8 0.39 7.34 0.37 1.64e-12 Type 2 diabetes; LUSC cis rs6546550 0.935 rs4853027 chr2:70039224 A/G cg02498382 chr2:70120550 SNRNP27 0.29 6.89 0.35 2.8e-11 Prevalent atrial fibrillation; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg18240814 chr5:107718300 FBXL17 0.34 6.42 0.33 4.64e-10 Tuberculosis; LUSC cis rs9303401 0.734 rs8073316 chr17:57211381 A/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.48 -7.23 -0.37 3.26e-12 Cognitive test performance; LUSC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.56 9.13 0.45 6.91e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg11657440 chr19:46296263 DMWD -0.75 -11.94 -0.55 1.29e-27 Coronary artery disease; LUSC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg22875332 chr1:76189707 ACADM 0.83 15.03 0.64 2.24e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1729951 0.575 rs361239 chr3:136701295 G/T cg12473912 chr3:136751656 NA 0.39 6.99 0.36 1.48e-11 Neuroticism; LUSC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg03060546 chr3:49711283 APEH 0.72 12.18 0.55 1.79e-28 Resting heart rate; LUSC cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg00071950 chr4:10020882 SLC2A9 0.63 10.39 0.49 4.28e-22 Bone mineral density; LUSC cis rs9420 1.000 rs9420 chr11:57510294 A/G cg02958346 chr11:57425731 CLP1 0.42 6.18 0.32 1.9e-9 Schizophrenia; LUSC cis rs754466 0.651 rs2004382 chr10:79650351 G/C cg17075019 chr10:79541650 NA -0.73 -11.76 -0.54 5.75e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs861020 0.771 rs661849 chr1:210001233 C/T cg09163369 chr1:210001066 C1orf107 0.58 6.83 0.35 4.08e-11 Orofacial clefts; LUSC cis rs9469578 1.000 rs9469578 chr6:33706479 C/T cg18708504 chr6:33715942 IP6K3 0.73 9.16 0.45 5.26e-18 Phosphorus levels; LUSC trans rs7824557 0.872 rs2572431 chr8:11105077 C/T cg08975724 chr8:8085496 FLJ10661 -0.49 -7.26 -0.37 2.81e-12 Retinal vascular caliber; LUSC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg00944433 chr1:107599041 PRMT6 0.37 6.78 0.35 5.37e-11 Facial morphology (factor 21, depth of nasal alae); LUSC trans rs2243480 1.000 rs316312 chr7:65596491 T/G cg10756647 chr7:56101905 PSPH 0.86 8.85 0.44 5.22e-17 Diabetic kidney disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09559324 chr16:31475905 ARMC5 0.47 6.27 0.32 1.12e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9467711 0.659 rs34246779 chr6:26549212 G/A cg09904177 chr6:26538194 HMGN4 -0.77 -6.04 -0.31 4.1e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs56399783 0.901 rs73033407 chr7:2878857 G/C cg19731401 chr7:2775893 GNA12 0.76 9.5 0.46 4.1e-19 Childhood ear infection; LUSC cis rs752010 0.631 rs4660549 chr1:42088102 A/G cg06885757 chr1:42089581 HIVEP3 0.61 12.37 0.56 3.3e-29 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs4780401 0.655 rs11648550 chr16:11787714 C/G cg01061890 chr16:11836724 TXNDC11 0.39 5.7 0.3 2.65e-8 Rheumatoid arthritis; LUSC cis rs17685 0.712 rs59659102 chr7:75710114 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.05 -0.4 1.52e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg05025164 chr4:1340916 KIAA1530 0.63 9.94 0.48 1.43e-20 Longevity; LUSC cis rs6542838 0.588 rs4851174 chr2:99530113 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.45 -0.38 7.98e-13 Fear of minor pain; LUSC cis rs478304 0.593 rs6591188 chr11:65467953 T/C cg27068330 chr11:65405492 SIPA1 -0.77 -10.84 -0.51 1.18e-23 Acne (severe); LUSC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11890956 chr21:40555474 PSMG1 1.03 20.03 0.74 3.61e-59 Cognitive function; LUSC cis rs7824557 0.602 rs11784458 chr8:11204184 G/A cg21293242 chr8:11204541 TDH 0.31 5.73 0.3 2.21e-8 Retinal vascular caliber; LUSC cis rs11997175 0.536 rs10096323 chr8:33776507 T/C ch.8.33884649F chr8:33765107 NA 0.42 6.28 0.33 1.03e-9 Body mass index; LUSC trans rs453301 0.522 rs2929309 chr8:9083771 C/A cg21775007 chr8:11205619 TDH -0.44 -6.21 -0.32 1.61e-9 Joint mobility (Beighton score); LUSC cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14442939 chr10:27389572 ANKRD26 -0.73 -8.94 -0.44 2.67e-17 Breast cancer; LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg22535103 chr8:58192502 C8orf71 -0.67 -7.57 -0.38 3.68e-13 Developmental language disorder (linguistic errors); LUSC cis rs868036 0.718 rs28463100 chr15:68078769 T/C cg24579218 chr15:68104479 NA -0.36 -6.45 -0.33 4.01e-10 Restless legs syndrome; LUSC cis rs2302777 0.507 rs9889716 chr17:38108298 A/G cg26162295 chr17:38119207 GSDMA -0.28 -6.33 -0.33 8.07e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs11098499 0.955 rs7685268 chr4:120162188 G/A cg24375607 chr4:120327624 NA 0.76 11.59 0.54 2.52e-26 Corneal astigmatism; LUSC cis rs6692729 0.933 rs2236915 chr1:227079222 C/G cg10327440 chr1:227177885 CDC42BPA 0.49 6.99 0.36 1.49e-11 Electrodermal activity; LUSC cis rs6665290 0.935 rs6693535 chr1:227197685 G/A cg10327440 chr1:227177885 CDC42BPA -1.22 -39.91 -0.91 3.76e-129 Myeloid white cell count; LUSC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg11663144 chr21:46675770 NA -0.35 -5.78 -0.3 1.71e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.08 0.44 9.64e-18 Motion sickness; LUSC cis rs10979 1.000 rs9321923 chr6:143897206 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Vitiligo; LUSC cis rs11122272 0.766 rs2024879 chr1:231528638 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.17 -0.49 2.5e-21 Hemoglobin concentration; LUSC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg19230755 chr7:65878503 NA -0.42 -6.04 -0.31 4.19e-9 Aortic root size; LUSC cis rs4950928 0.823 rs4950882 chr1:203164848 A/G cg17014757 chr1:203156097 CHI3L1 -0.43 -7.68 -0.39 1.73e-13 YKL-40 levels; LUSC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.3 0.53 2.82e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs62400317 0.826 rs62400335 chr6:45347782 G/A cg18551225 chr6:44695536 NA -0.43 -7.18 -0.37 4.6e-12 Total body bone mineral density; LUSC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg20243544 chr17:37824526 PNMT 0.41 6.25 0.32 1.23e-9 Self-reported allergy; LUSC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg15691649 chr6:25882328 NA -0.39 -5.73 -0.3 2.25e-8 Intelligence (multi-trait analysis); LUSC trans rs1728785 1.000 rs1099296 chr16:68588653 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.29 0.41 2.71e-15 Ulcerative colitis; LUSC cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg24642439 chr20:33292090 TP53INP2 0.5 7.32 0.37 1.87e-12 Height; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25707994 chr7:157129685 DNAJB6 0.4 7.02 0.36 1.26e-11 Triglycerides; LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg00814883 chr7:100076585 TSC22D4 -0.67 -9.02 -0.44 1.51e-17 Platelet count; LUSC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg11764359 chr7:65958608 NA -0.7 -10.85 -0.51 1.03e-23 Aortic root size; LUSC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg07936489 chr17:37558343 FBXL20 -0.7 -9.68 -0.47 1.04e-19 Lung function (FEV1); LUSC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg17724175 chr1:150552817 MCL1 0.32 5.69 0.3 2.73e-8 Melanoma; LUSC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs9635231 1 rs9635231 chr14:55887703 C/T cg04306507 chr14:55594613 LGALS3 -0.32 -6.41 -0.33 5.02e-10 Pediatric bone mineral density (femoral neck); LUSC cis rs1790761 0.505 rs7945035 chr11:67348162 A/G cg24690094 chr11:67383802 NA -0.3 -5.75 -0.3 1.98e-8 Mean corpuscular volume; LUSC cis rs2235642 0.592 rs743963 chr16:1657350 A/T cg26528668 chr16:1614120 IFT140 0.43 7.13 0.36 6.37e-12 Coronary artery disease; LUSC cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg15839431 chr19:19639596 YJEFN3 0.66 7.17 0.37 4.73e-12 Bipolar disorder; LUSC trans rs72674100 1.000 rs4632666 chr4:97990707 A/T cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7582180 0.663 rs4850929 chr2:100990707 A/C cg08017756 chr2:100939284 LONRF2 -0.41 -7.66 -0.39 2.1e-13 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg15494558 chr6:150152522 LRP11 0.34 5.81 0.3 1.45e-8 Lung cancer; LUSC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg22823121 chr1:150693482 HORMAD1 0.48 7.06 0.36 9.78e-12 Melanoma; LUSC cis rs1950626 0.716 rs34158896 chr14:101447373 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.76 0.39 1.03e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs79387448 0.745 rs76720903 chr2:103162826 G/A cg09003973 chr2:102972529 NA 0.89 8.59 0.43 3.43e-16 Gut microbiota (bacterial taxa); LUSC cis rs600231 0.665 rs1784859 chr11:65220749 A/G cg21890820 chr11:65308645 LTBP3 -0.49 -7.35 -0.37 1.56e-12 Bone mineral density; LUSC cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg24812749 chr6:127587940 RNF146 0.63 8.95 0.44 2.58e-17 Breast cancer; LUSC cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg06784218 chr1:46089804 CCDC17 0.55 11.2 0.52 6.11e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg12311346 chr5:56204834 C5orf35 -0.61 -9.32 -0.45 1.6e-18 Coronary artery disease; LUSC cis rs713587 0.563 rs2384057 chr2:25100167 C/G cg15423357 chr2:25149977 NA 0.39 7.57 0.38 3.74e-13 Body mass index in non-asthmatics; LUSC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg17376030 chr22:41985996 PMM1 0.47 5.99 0.31 5.5e-9 Vitiligo; LUSC cis rs239198 0.602 rs4840157 chr6:101326375 C/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.37 -0.33 6.19e-10 Menarche (age at onset); LUSC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg23630131 chr7:65973040 NA 0.21 5.93 0.31 7.77e-9 Aortic root size; LUSC cis rs1348850 0.632 rs12471621 chr2:178502353 T/C cg22681709 chr2:178499509 PDE11A -0.6 -12.05 -0.55 5.29e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.75e-17 Prudent dietary pattern; LUSC cis rs12545109 0.800 rs2609979 chr8:57390066 G/A cg09654669 chr8:57350985 NA -0.51 -7.04 -0.36 1.1e-11 Obesity-related traits; LUSC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC trans rs7937682 1.000 rs2186839 chr11:111534442 T/G cg18187862 chr3:45730750 SACM1L 0.55 7.01 0.36 1.35e-11 Primary sclerosing cholangitis; LUSC cis rs36093844 0.800 rs75203358 chr11:85567390 A/G cg25872744 chr11:85566296 CCDC83 -0.45 -5.85 -0.3 1.16e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs80282103 0.867 rs11819178 chr10:1098417 A/G cg08668510 chr10:1095578 IDI1 0.69 6.23 0.32 1.39e-9 Glomerular filtration rate (creatinine); LUSC cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg26373071 chr5:1325741 CLPTM1L 0.42 7.62 0.39 2.57e-13 Lung cancer; LUSC cis rs1559088 0.948 rs3760893 chr19:33597930 C/A cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.38e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1577917 0.958 rs12203457 chr6:86689277 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.41 -0.33 5.09e-10 Response to antipsychotic treatment; LUSC cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs6500395 0.962 rs1564979 chr16:48647017 C/A cg04672837 chr16:48644449 N4BP1 0.47 6.66 0.34 1.16e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9814567 1.000 rs62271514 chr3:134298554 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs2404602 0.692 rs12437733 chr15:77155562 A/G cg22467129 chr15:76604101 ETFA -0.44 -6.85 -0.35 3.61e-11 Blood metabolite levels; LUSC trans rs7607980 1.000 rs79953491 chr2:165555539 A/G cg21604450 chr1:66998563 SGIP1 0.53 6.06 0.31 3.6e-9 Fasting blood insulin (BMI interaction);Fasting blood insulin;Type 2 diabetes; LUSC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg00933542 chr6:150070202 PCMT1 0.33 6.82 0.35 4.37e-11 Lung cancer; LUSC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg18230493 chr5:56204884 C5orf35 -0.68 -10.47 -0.5 2.23e-22 Coronary artery disease; LUSC cis rs11971779 0.616 rs10269683 chr7:139100868 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.25 0.32 1.25e-9 Diisocyanate-induced asthma; LUSC cis rs782590 0.967 rs10496050 chr2:55806313 C/T cg03859395 chr2:55845619 SMEK2 0.87 16.02 0.66 2.91e-43 Metabolic syndrome; LUSC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg08508325 chr11:3079039 CARS -0.5 -11.54 -0.53 3.81e-26 Longevity; LUSC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.78 -0.39 9.03e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs56283067 0.578 rs2894641 chr6:45393174 A/G cg20913747 chr6:44695427 NA -0.42 -6.07 -0.32 3.56e-9 Total body bone mineral density; LUSC cis rs7127900 0.614 rs11564708 chr11:2206326 C/G cg25635251 chr11:2234043 NA 0.61 8.36 0.42 1.76e-15 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); LUSC cis rs11955175 0.717 rs41271053 chr5:40835393 A/C cg17351974 chr5:40835760 RPL37 0.68 5.73 0.3 2.23e-8 Bipolar disorder and schizophrenia; LUSC cis rs4588572 0.537 rs7702000 chr5:77730556 A/G cg11547950 chr5:77652471 NA -0.48 -7.19 -0.37 4.18e-12 Triglycerides; LUSC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg01097406 chr16:89675127 NA 0.33 6.34 0.33 7.27e-10 Vitiligo; LUSC cis rs4819852 0.958 rs2238792 chr22:19983213 C/T cg07821417 chr22:19972146 ARVCF 0.31 5.79 0.3 1.65e-8 Pulse pressure; LUSC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg04455712 chr21:45112962 RRP1B 0.47 9.0 0.44 1.71e-17 Mean corpuscular volume; LUSC trans rs7829975 0.623 rs10092965 chr8:8373485 A/G cg21775007 chr8:11205619 TDH 0.42 6.13 0.32 2.43e-9 Mood instability; LUSC cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg00484396 chr16:3507460 NAT15 0.49 7.38 0.37 1.28e-12 Body mass index (adult); LUSC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs6545883 0.929 rs10193666 chr2:61629408 C/T cg15711740 chr2:61764176 XPO1 0.43 6.53 0.34 2.4e-10 Tuberculosis; LUSC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 11.25 0.52 4.26e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12627970 0.565 rs5757613 chr22:39715262 G/A cg17798944 chr22:39715225 SNORD43;RPL3 0.82 14.48 0.62 3.09e-37 Inflammatory bowel disease; LUSC cis rs7246657 0.882 rs10412043 chr19:37826626 A/C cg23950597 chr19:37808831 NA -0.64 -7.9 -0.4 4.2e-14 Coronary artery calcification; LUSC cis rs7615952 0.604 rs9837847 chr3:125623919 G/A cg05084668 chr3:125655381 ALG1L -0.89 -12.87 -0.58 4.67e-31 Blood pressure (smoking interaction); LUSC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg17279839 chr7:150038598 RARRES2 0.49 7.49 0.38 6.19e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg21984481 chr17:79567631 NPLOC4 -0.72 -15.12 -0.64 1.07e-39 Eye color traits; LUSC cis rs2236918 0.687 rs2797601 chr1:242029249 C/G cg17736920 chr1:242011382 EXO1 0.4 6.35 0.33 7.03e-10 Menopause (age at onset); LUSC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg04398451 chr17:18023971 MYO15A -0.47 -7.69 -0.39 1.66e-13 Total body bone mineral density; LUSC cis rs17401966 0.540 rs6674949 chr1:10458480 A/G cg17425144 chr1:10567563 PEX14 -0.32 -5.73 -0.3 2.2e-8 Hepatocellular carcinoma; LUSC trans rs61931739 0.890 rs1849160 chr12:34140191 A/G cg13010199 chr12:38710504 ALG10B 0.43 6.72 0.35 7.83e-11 Morning vs. evening chronotype; LUSC cis rs939658 0.683 rs1474256 chr15:79463847 C/T cg17916960 chr15:79447300 NA 0.39 7.06 0.36 9.75e-12 Refractive error; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg02951883 chr7:2050386 MAD1L1 -0.46 -7.88 -0.4 4.7e-14 Bipolar disorder and schizophrenia; LUSC cis rs72829446 0.530 rs7210292 chr17:7380305 G/T cg02795151 chr17:7402630 POLR2A 0.61 7.43 0.38 9.45e-13 Androgen levels; LUSC cis rs2273669 0.667 rs12208578 chr6:109369745 T/C cg05315195 chr6:109294784 ARMC2 -0.53 -5.79 -0.3 1.65e-8 Prostate cancer; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg23158103 chr7:148848205 ZNF398 -0.39 -6.19 -0.32 1.77e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4629710 0.592 rs4310080 chr6:131538377 T/G cg12700074 chr6:131571435 AKAP7 -0.37 -6.15 -0.32 2.17e-9 Multiple myeloma (IgH translocation); LUSC trans rs1409005 1.000 rs76135795 chr13:79161205 C/T cg04653021 chr3:122514541 DIRC2 0.47 6.0 0.31 5.25e-9 Serum thyroid-stimulating hormone levels; LUSC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg05754148 chr16:3507555 NAT15 -0.83 -8.86 -0.44 4.97e-17 Tuberculosis; LUSC cis rs7647973 0.925 rs11130183 chr3:49228946 A/G cg07636037 chr3:49044803 WDR6 0.68 8.81 0.43 6.81e-17 Menarche (age at onset); LUSC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg11812906 chr14:75593930 NEK9 0.65 11.2 0.52 6.3e-25 Height; LUSC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg18305652 chr10:134549665 INPP5A 0.44 6.68 0.34 9.79e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg10909506 chr17:38081995 ORMDL3 0.34 6.14 0.32 2.39e-9 Self-reported allergy; LUSC trans rs17685 0.753 rs869806 chr7:75688623 C/T cg19862616 chr7:65841803 NCRNA00174 1.11 19.54 0.73 3.07e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg18904891 chr8:8559673 CLDN23 -0.41 -6.13 -0.32 2.51e-9 Neuroticism; LUSC cis rs7705502 1.000 rs747472 chr5:173353514 T/C cg18693985 chr5:173351052 CPEB4 -0.38 -5.94 -0.31 7.17e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9640161 0.711 rs10259796 chr7:150050427 T/C cg17279839 chr7:150038598 RARRES2 0.42 6.57 0.34 1.92e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg06028605 chr16:24865363 SLC5A11 0.66 9.73 0.47 7.15e-20 Intelligence (multi-trait analysis); LUSC cis rs2540226 0.816 rs1986876 chr2:39987398 A/G cg23576258 chr2:39999331 THUMPD2 0.34 5.92 0.31 7.79e-9 Personality dimensions; LUSC cis rs11583043 0.575 rs56403901 chr1:101586047 A/T cg11406453 chr1:101602562 NA -0.4 -6.86 -0.35 3.31e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg03264133 chr6:25882463 NA -0.52 -9.48 -0.46 4.99e-19 Blood metabolite levels; LUSC trans rs961253 0.556 rs6054140 chr20:6331643 A/G cg21095983 chr6:86352623 SYNCRIP 0.45 6.81 0.35 4.68e-11 Colorectal cancer; LUSC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg19748678 chr4:122722346 EXOSC9 0.74 11.22 0.52 5.1e-25 Type 2 diabetes; LUSC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg12311346 chr5:56204834 C5orf35 -0.92 -13.49 -0.59 2.07e-33 Initial pursuit acceleration; LUSC trans rs11098499 0.865 rs4507344 chr4:120307485 C/A cg25214090 chr10:38739885 LOC399744 0.54 7.83 0.39 6.41e-14 Corneal astigmatism; LUSC cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg11764359 chr7:65958608 NA -0.68 -10.95 -0.51 4.86e-24 Aortic root size; LUSC cis rs7617480 0.544 rs6442129 chr3:48735256 T/C cg21141812 chr3:48556323 PFKFB4 0.35 6.36 0.33 6.81e-10 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs835154 1.000 rs835154 chr5:14876569 A/G cg14843632 chr5:14870594 ANKH -0.38 -7.4 -0.38 1.08e-12 Blood metabolite levels; LUSC trans rs61931739 0.620 rs745608 chr12:33711564 A/G cg26384229 chr12:38710491 ALG10B 0.42 6.13 0.32 2.41e-9 Morning vs. evening chronotype; LUSC cis rs11676348 0.935 rs2230054 chr2:219000310 C/T cg06547715 chr2:218990976 CXCR2 0.31 5.88 0.31 9.97e-9 Ulcerative colitis; LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg00166722 chr3:10149974 C3orf24 0.62 8.47 0.42 8.07e-16 Alzheimer's disease; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg00817870 chr12:65153201 GNS 0.41 6.35 0.33 6.97e-10 Metabolite levels (Pyroglutamine); LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg26314531 chr2:26401878 FAM59B -0.7 -9.75 -0.47 6.29e-20 Gut microbiome composition (summer); LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg06877462 chr1:205807181 PM20D1 -0.39 -7.02 -0.36 1.21e-11 Menarche (age at onset); LUSC cis rs9326248 0.581 rs10892072 chr11:116960313 G/A cg26566898 chr11:117069891 TAGLN 0.34 6.51 0.34 2.82e-10 Blood protein levels; LUSC cis rs807669 1.000 rs807669 chr22:19154522 T/C cg02655711 chr22:19163373 SLC25A1 0.85 16.29 0.67 2.51e-44 Metabolite levels; LUSC cis rs11992162 0.573 rs13264994 chr8:11782759 G/A cg21775007 chr8:11205619 TDH -0.41 -5.79 -0.3 1.62e-8 Monocyte count; LUSC trans rs9329221 0.513 rs4841296 chr8:10105447 C/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.97 -0.36 1.71e-11 Neuroticism; LUSC cis rs4834770 1.000 rs6823963 chr4:120242164 A/C cg24375607 chr4:120327624 NA 0.41 5.84 0.3 1.26e-8 Blood protein levels; LUSC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg20908204 chr19:46285434 DMPK 0.41 8.22 0.41 4.62e-15 Coronary artery disease; LUSC trans rs11039798 0.777 rs2202454 chr11:49011009 T/C cg03929089 chr4:120376271 NA 0.74 6.78 0.35 5.58e-11 Axial length; LUSC cis rs9300255 0.537 rs1619561 chr12:123620268 G/C cg00376283 chr12:123451042 ABCB9 0.66 8.35 0.42 1.82e-15 Neutrophil percentage of white cells; LUSC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg06634786 chr22:41940651 POLR3H 0.49 5.99 0.31 5.54e-9 Vitiligo; LUSC cis rs7202877 0.706 rs1074961 chr16:75389484 C/T cg03315344 chr16:75512273 CHST6 0.44 6.51 0.34 2.74e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs710216 0.718 rs841851 chr1:43401829 A/G cg03128534 chr1:43423976 SLC2A1 0.46 5.88 0.31 9.93e-9 Red cell distribution width; LUSC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg04450456 chr4:17643702 FAM184B 0.39 6.6 0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg17554472 chr22:41940697 POLR3H -0.49 -5.8 -0.3 1.52e-8 Vitiligo; LUSC cis rs2274273 0.682 rs8008134 chr14:55507520 T/C cg04306507 chr14:55594613 LGALS3 0.5 11.03 0.52 2.44e-24 Protein biomarker; LUSC cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg13319975 chr6:146136371 FBXO30 0.5 7.48 0.38 6.55e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7771547 0.642 rs605684 chr6:36493265 T/C cg07856975 chr6:36356162 ETV7 0.36 6.19 0.32 1.72e-9 Platelet distribution width; LUSC cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg03146154 chr1:46216737 IPP 0.56 8.36 0.42 1.75e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs72781680 1.000 rs72796337 chr2:24142957 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs2721195 1.000 rs1871541 chr8:145681713 G/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.78 -13.78 -0.6 1.62e-34 Age at first birth; LUSC cis rs710216 0.879 rs710218 chr1:43427218 A/T cg03128534 chr1:43423976 SLC2A1 0.51 6.54 0.34 2.28e-10 Red cell distribution width; LUSC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg05585544 chr11:47624801 NA -0.42 -7.32 -0.37 1.91e-12 Subjective well-being; LUSC cis rs611744 0.563 rs7815105 chr8:109298794 C/T cg18478394 chr8:109455254 TTC35 0.46 6.65 0.34 1.21e-10 Dupuytren's disease; LUSC cis rs13394619 1.000 rs4669752 chr2:11727988 G/C cg07314298 chr2:11723111 GREB1 -0.57 -10.09 -0.48 4.41e-21 Endometriosis; LUSC cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs72901758 0.669 rs17641275 chr17:76247796 A/C cg26068271 chr17:76253126 NA -0.52 -9.73 -0.47 7.19e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7584330 0.955 rs7581882 chr2:238390745 T/C cg16989719 chr2:238392110 NA -0.42 -7.19 -0.37 4.35e-12 Prostate cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04651707 chr7:43622869 STK17A -0.46 -6.23 -0.32 1.39e-9 Hepatitis; LUSC cis rs7223966 1.000 rs78172786 chr17:61847114 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.7 0.34 8.64e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9611565 0.649 rs5758434 chr22:42116163 G/A cg03806693 chr22:41940476 POLR3H 0.87 12.97 0.58 2.02e-31 Vitiligo; LUSC trans rs10435719 0.899 rs9693925 chr8:11789963 A/G cg08975724 chr8:8085496 FLJ10661 0.48 7.02 0.36 1.24e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs3862030 0.836 rs12771867 chr10:104246691 G/A cg05855489 chr10:104503620 C10orf26 0.51 7.75 0.39 1.14e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs859767 0.741 rs6713239 chr2:135434849 C/T cg12500956 chr2:135428796 TMEM163 -0.28 -6.4 -0.33 5.39e-10 Neuroticism; LUSC cis rs7119 0.635 rs938090 chr15:77879975 A/G cg27398640 chr15:77910606 LINGO1 0.35 8.28 0.41 3.07e-15 Type 2 diabetes; LUSC cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg24692254 chr21:30365293 RNF160 0.69 11.35 0.53 1.8e-25 Pancreatic cancer; LUSC cis rs116988415 0.539 rs17180350 chr14:65249066 C/T cg00114569 chr14:65239327 SPTB 0.63 6.92 0.35 2.28e-11 Daytime sleep phenotypes; LUSC trans rs4332037 0.539 rs57148375 chr7:2025001 G/C cg25206134 chr2:45395956 NA 0.59 6.72 0.35 7.76e-11 Bipolar disorder; LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.52 -7.38 -0.37 1.27e-12 Renal function-related traits (BUN); LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg08677398 chr8:58056175 NA 0.53 7.05 0.36 1.04e-11 Developmental language disorder (linguistic errors); LUSC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg23887609 chr12:130822674 PIWIL1 0.48 7.03 0.36 1.19e-11 Menopause (age at onset); LUSC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg11663144 chr21:46675770 NA -0.4 -6.81 -0.35 4.49e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg05025164 chr4:1340916 KIAA1530 0.42 6.67 0.34 1.09e-10 Obesity-related traits; LUSC cis rs1124376 1.000 rs11712709 chr3:20139777 G/C cg05072819 chr3:20081367 KAT2B 0.67 7.49 0.38 6.17e-13 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.836 rs7199062 chr16:75474827 G/A cg03315344 chr16:75512273 CHST6 0.53 10.39 0.49 4.26e-22 Dupuytren's disease; LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg08200582 chr11:442649 ANO9 -0.52 -5.96 -0.31 6.31e-9 Body mass index; LUSC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.5 6.59 0.34 1.74e-10 Tuberculosis; LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg20295408 chr7:1910781 MAD1L1 -0.48 -6.83 -0.35 4.05e-11 Bipolar disorder and schizophrenia; LUSC cis rs9393777 0.623 rs16891717 chr6:26477143 T/A cg12292205 chr6:26970375 C6orf41 -0.63 -7.57 -0.38 3.72e-13 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.958 rs11755864 chr6:86691791 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.57 -0.34 1.88e-10 Response to antipsychotic treatment; LUSC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg24549020 chr5:56110836 MAP3K1 0.47 5.66 0.3 3.31e-8 Initial pursuit acceleration; LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.14 0.32 2.34e-9 Alzheimer's disease; LUSC cis rs8027181 1.000 rs7164727 chr15:73093991 C/T cg25632853 chr15:73088954 NA 0.33 6.6 0.34 1.57e-10 Triglyceride levels; LUSC trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg15704280 chr7:45808275 SEPT13 -0.98 -14.37 -0.62 9.01e-37 Height; LUSC cis rs3812762 0.833 rs3850933 chr11:8801135 C/A cg21881798 chr11:8931708 C11orf17;ST5 0.39 6.73 0.35 7.57e-11 Hypospadias; LUSC cis rs4727027 0.704 rs7787753 chr7:148901779 A/T cg23583168 chr7:148888333 NA -0.93 -18.52 -0.71 3.49e-53 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg11764359 chr7:65958608 NA 0.68 11.06 0.52 2e-24 Aortic root size; LUSC cis rs7212590 0.655 rs34687426 chr17:57997857 A/G cg10252138 chr17:58120427 NA -0.73 -7.09 -0.36 7.8e-12 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC trans rs1493916 0.870 rs7235698 chr18:31382486 A/G cg15819921 chr19:927150 ARID3A -0.44 -6.61 -0.34 1.51e-10 Life satisfaction; LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg11645453 chr3:52864694 ITIH4 0.34 7.82 0.39 6.91e-14 Bipolar disorder; LUSC cis rs7267979 1.000 rs6083805 chr20:25317356 T/C cg08601574 chr20:25228251 PYGB -0.44 -6.72 -0.35 7.65e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11583043 1.000 rs7535068 chr1:101490329 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.25 0.32 1.22e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs67539049 1.000 rs77865852 chr8:11303336 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.41 -6.33 -0.33 7.98e-10 Itch intensity from mosquito bite; LUSC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg05872129 chr22:39784769 NA -0.59 -10.0 -0.48 9.36e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs6828577 0.695 rs62324878 chr4:119455605 G/A cg26518628 chr1:97050305 NA -0.52 -7.61 -0.38 2.77e-13 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg03909863 chr11:638404 DRD4 -0.41 -6.18 -0.32 1.84e-9 Systemic lupus erythematosus; LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9796 0.516 rs28473405 chr15:41293170 C/T cg18705301 chr15:41695430 NDUFAF1 -0.55 -9.33 -0.45 1.47e-18 Menopause (age at onset); LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg19318889 chr4:1322082 MAEA -0.39 -6.41 -0.33 4.82e-10 Obesity-related traits; LUSC cis rs11030122 0.632 rs4910596 chr11:4084604 A/G cg18678763 chr11:4115507 RRM1 -0.47 -6.32 -0.33 8.53e-10 Mean platelet volume;Platelet distribution width; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg07395648 chr5:131743802 NA -0.39 -5.85 -0.3 1.2e-8 Acylcarnitine levels; LUSC cis rs6484504 0.652 rs485265 chr11:31407788 G/A cg06552810 chr11:31128660 NA 0.36 6.16 0.32 2.1e-9 Red blood cell count; LUSC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg13628971 chr7:2884303 GNA12 0.42 6.25 0.32 1.26e-9 Height; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg11965913 chr1:205819406 PM20D1 1.01 24.37 0.8 4.34e-76 Menarche (age at onset); LUSC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4474465 1.000 rs10793314 chr11:78174196 G/C cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg19812747 chr11:111475976 SIK2 -0.45 -6.16 -0.32 2.1e-9 Primary sclerosing cholangitis; LUSC cis rs9527 0.590 rs10883818 chr10:104759586 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.4 -0.33 5.4e-10 Arsenic metabolism; LUSC cis rs7587476 0.601 rs17489231 chr2:215673739 T/G cg04004882 chr2:215674386 BARD1 -0.52 -7.28 -0.37 2.42e-12 Neuroblastoma; LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg03188948 chr7:1209495 NA 0.61 6.38 0.33 5.97e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7560272 0.538 rs11126414 chr2:73932044 G/A cg20560298 chr2:73613845 ALMS1 0.38 5.72 0.3 2.43e-8 Schizophrenia; LUSC cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg08999081 chr20:33150536 PIGU 0.51 10.12 0.48 3.48e-21 Glomerular filtration rate (creatinine); LUSC cis rs9308433 0.798 rs10157166 chr1:214484950 C/T cg06198575 chr1:214491504 SMYD2 0.45 7.12 0.36 6.86e-12 IgG glycosylation; LUSC cis rs1790761 0.692 rs674783 chr11:67339076 C/T cg08355456 chr11:67383691 NA 0.38 7.01 0.36 1.35e-11 Mean corpuscular volume; LUSC cis rs9303401 0.659 rs62083362 chr17:56846464 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.34 0.59 7.79e-33 Cognitive test performance; LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.84 -0.57 5.88e-31 Platelet count; LUSC cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.44 -0.33 4.25e-10 Extrinsic epigenetic age acceleration; LUSC cis rs77741769 0.571 rs1696357 chr12:121348649 A/G cg02419362 chr12:121203948 SPPL3 0.44 8.47 0.42 8.13e-16 Mean corpuscular volume; LUSC cis rs6543140 0.964 rs4851578 chr2:103028951 T/G cg09003973 chr2:102972529 NA 0.55 7.19 0.37 4.2e-12 Blood protein levels; LUSC cis rs16867321 0.507 rs2013577 chr2:181370505 C/T cg23363182 chr2:181467187 NA -0.45 -7.31 -0.37 1.96e-12 Obesity; LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.56 0.65 1.98e-41 Platelet count; LUSC cis rs9325144 0.560 rs10785562 chr12:38637419 A/C cg13010199 chr12:38710504 ALG10B -0.52 -7.85 -0.39 5.58e-14 Morning vs. evening chronotype; LUSC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg02423579 chr7:2872169 GNA12 -0.46 -6.3 -0.33 9.36e-10 Height; LUSC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.13 -0.32 2.41e-9 Life satisfaction; LUSC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg00339695 chr16:24857497 SLC5A11 0.61 9.52 0.46 3.52e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg11057378 chr10:81107060 PPIF 0.34 6.04 0.31 4.15e-9 Height; LUSC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs5758659 0.657 rs5758587 chr22:42517636 C/G cg04733989 chr22:42467013 NAGA -0.4 -6.58 -0.34 1.77e-10 Cognitive function; LUSC cis rs7786877 0.521 rs4729607 chr7:100326744 T/A cg00334542 chr7:100209784 MOSPD3 -0.48 -5.82 -0.3 1.42e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg23283495 chr1:209979779 IRF6 0.44 7.21 0.37 3.74e-12 Monobrow; LUSC cis rs1451375 0.652 rs10249420 chr7:50623451 C/G cg18232548 chr7:50535776 DDC -0.47 -6.52 -0.34 2.56e-10 Malaria; LUSC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg15595755 chr5:1867978 NA 0.45 8.2 0.41 5.37e-15 Cardiovascular disease risk factors; LUSC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg20307385 chr11:47447363 PSMC3 0.44 5.8 0.3 1.58e-8 Subjective well-being; LUSC cis rs3771570 0.579 rs62190373 chr2:242388685 G/A cg21155796 chr2:242212141 HDLBP 0.6 6.51 0.34 2.8e-10 Prostate cancer; LUSC cis rs4689388 0.610 rs4328980 chr4:6281756 A/G cg00701064 chr4:6280414 WFS1 0.5 10.42 0.5 3.27e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6594499 0.500 rs10491424 chr5:110453806 T/C cg04022379 chr5:110408740 TSLP 0.57 8.62 0.43 2.81e-16 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.22 -0.72 5.88e-56 Height; LUSC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.38 0.42 1.53e-15 Tonsillectomy; LUSC cis rs6537837 0.838 rs6537830 chr1:110107044 A/G cg05049280 chr1:110155535 GNAT2 0.39 5.74 0.3 2.12e-8 Major depressive disorder; LUSC trans rs1728785 1.000 rs1749792 chr16:68569440 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs2050392 0.630 rs303428 chr10:30739058 C/T cg18806716 chr10:30721971 MAP3K8 0.44 6.87 0.35 3.11e-11 Inflammatory bowel disease; LUSC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg02951883 chr7:2050386 MAD1L1 0.55 9.96 0.48 1.21e-20 Bipolar disorder and schizophrenia; LUSC cis rs13315871 0.929 rs7643185 chr3:58311158 A/C cg12435725 chr3:58293450 RPP14 0.67 7.17 0.37 4.88e-12 Cholesterol, total; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.62e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs16912285 0.748 rs7952223 chr11:24256443 G/C ch.11.24196551F chr11:24239977 NA 0.89 9.13 0.45 6.92e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01939664 chr1:33722135 ZNF362 -0.49 -5.96 -0.31 6.56e-9 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.49 -8.07 -0.4 1.27e-14 Bipolar disorder; LUSC cis rs1538970 1.000 rs61791368 chr1:45867944 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.65 0.3 3.43e-8 Platelet count; LUSC cis rs1577917 0.740 rs12212560 chr6:86342679 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.9 -0.4 4.05e-14 Response to antipsychotic treatment; LUSC cis rs1009647 0.583 rs68175860 chr14:55633590 T/C cg04306507 chr14:55594613 LGALS3 0.46 6.35 0.33 6.89e-10 Testicular germ cell tumor; LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs6104690 1.000 rs6078005 chr20:10983151 T/C cg07172334 chr21:31655261 KRTAP24-1 -0.34 -6.11 -0.32 2.85e-9 Bladder cancer; LUSC cis rs7572644 0.621 rs4462754 chr2:28063994 C/T cg27432699 chr2:27873401 GPN1 0.51 6.96 0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg00945038 chr17:61921165 SMARCD2 0.53 9.25 0.45 2.66e-18 Prudent dietary pattern; LUSC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs9462027 0.607 rs205259 chr6:34564066 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.21 -0.32 1.59e-9 Systemic lupus erythematosus; LUSC trans rs3733585 0.638 rs6414766 chr4:9956474 G/A cg26043149 chr18:55253948 FECH -0.45 -7.09 -0.36 8.09e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4319547 0.695 rs6488939 chr12:122858250 T/C cg05707623 chr12:122985044 ZCCHC8 -0.55 -6.87 -0.35 3.23e-11 Body mass index; LUSC cis rs11190604 1.000 rs10883513 chr10:102316964 A/G cg16342193 chr10:102329863 NA -0.36 -6.06 -0.31 3.64e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg15147215 chr3:52552868 STAB1 -0.31 -6.09 -0.32 3.15e-9 Bipolar disorder; LUSC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg26818010 chr10:134567672 INPP5A -0.87 -10.88 -0.51 8.59e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs77216612 0.877 rs66561220 chr12:12878765 T/C cg09462578 chr12:12878428 APOLD1 -1.0 -17.21 -0.69 5.77e-48 Lymphocyte counts; LUSC cis rs7954584 0.626 rs12809676 chr12:122442381 C/A cg10207240 chr12:122356781 WDR66 0.43 6.0 0.31 5.28e-9 Mean corpuscular volume; LUSC cis rs11098499 0.722 rs28713555 chr4:120251995 C/T cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.41e-23 Bladder cancer; LUSC cis rs9303401 0.659 rs17822908 chr17:56801778 T/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs11264213 0.901 rs72661636 chr1:36426483 T/C cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.39e-14 Schizophrenia; LUSC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg07148914 chr20:33460835 GGT7 -0.53 -8.1 -0.41 1.05e-14 Glomerular filtration rate (creatinine); LUSC cis rs2404602 0.692 rs12904198 chr15:77146978 G/A cg23625390 chr15:77176239 SCAPER 0.47 7.09 0.36 8.04e-12 Blood metabolite levels; LUSC cis rs637571 0.522 rs649000 chr11:65742933 T/C cg26695010 chr11:65641043 EFEMP2 -0.46 -6.92 -0.35 2.32e-11 Eosinophil percentage of white cells; LUSC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.05 -0.36 1.01e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs870825 0.616 rs3184982 chr4:185615768 T/G cg04058563 chr4:185651563 MLF1IP 0.86 13.29 0.59 1.2e-32 Blood protein levels; LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg22963979 chr7:1858916 MAD1L1 -0.6 -9.44 -0.46 6.45e-19 Bipolar disorder and schizophrenia; LUSC cis rs2086824 0.702 rs3114896 chr16:89393562 C/T cg06640241 chr16:89574553 SPG7 -0.53 -7.99 -0.4 2.28e-14 Multiple myeloma (IgH translocation); LUSC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg02549819 chr16:58548995 SETD6 0.94 9.18 0.45 4.63e-18 Schizophrenia; LUSC cis rs4713675 0.584 rs2966 chr6:33689520 C/T cg14003231 chr6:33640908 ITPR3 0.29 5.7 0.3 2.59e-8 Plateletcrit; LUSC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg18252515 chr7:66147081 NA -1.25 -14.23 -0.61 3.05e-36 Diabetic kidney disease; LUSC cis rs10752881 0.967 rs8179361 chr1:182974572 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.82e-23 Colorectal cancer; LUSC cis rs11608355 0.545 rs7315846 chr12:109908617 T/C cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs7178572 1.000 rs12904938 chr15:77721225 A/G cg22256960 chr15:77711686 NA -0.54 -9.04 -0.44 1.29e-17 Type 2 diabetes; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg15112475 chr7:1198522 ZFAND2A -0.29 -5.98 -0.31 5.66e-9 Longevity;Endometriosis; LUSC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.23 0.52 4.92e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.930 rs10929375 chr2:15684483 A/G cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC trans rs7618501 0.633 rs4688690 chr3:50022292 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.92 0.44 3.12e-17 Intelligence (multi-trait analysis); LUSC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg12463550 chr7:65579703 CRCP -0.52 -7.5 -0.38 5.79e-13 Aortic root size; LUSC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.27 0.41 3.27e-15 Melanoma; LUSC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg27398817 chr8:82754497 SNX16 -0.64 -8.14 -0.41 7.68e-15 Diastolic blood pressure; LUSC cis rs9640161 0.830 rs1051823 chr7:150070814 G/A cg17279839 chr7:150038598 RARRES2 0.36 5.86 0.31 1.13e-8 Blood protein levels;Circulating chemerin levels; LUSC trans rs11088226 0.681 rs9622 chr21:33951068 T/C cg09050820 chr6:167586206 TCP10L2 0.75 9.93 0.48 1.54e-20 Gastritis; LUSC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg05234568 chr11:5960015 NA -0.56 -8.15 -0.41 7.16e-15 DNA methylation (variation); LUSC trans rs11935423 0.778 rs11946658 chr4:100491680 C/A cg02164153 chr5:172068145 NEURL1B -0.47 -6.1 -0.32 3e-9 Gut microbiome composition (summer); LUSC cis rs921968 0.643 rs2243911 chr2:219529348 C/T cg02176678 chr2:219576539 TTLL4 -0.58 -10.59 -0.5 8.77e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs1775715 0.737 rs55859032 chr10:32213239 C/T cg18675610 chr10:32216311 ARHGAP12 0.29 6.43 0.33 4.5e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.68 10.28 0.49 1.02e-21 Lymphocyte counts; LUSC cis rs9472414 0.510 rs3997503 chr6:44708416 G/A cg20913747 chr6:44695427 NA 0.38 5.77 0.3 1.81e-8 Height; LUSC cis rs11039100 1.000 rs35466594 chr11:5826684 T/G cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7428 0.527 rs1053560 chr2:85546192 C/T cg24342717 chr2:85555507 TGOLN2 -0.74 -12.31 -0.56 5.74e-29 Ear protrusion; LUSC cis rs981844 0.753 rs62325149 chr4:154728006 G/C cg14289246 chr4:154710475 SFRP2 0.44 5.86 0.31 1.09e-8 Response to statins (LDL cholesterol change); LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg15790184 chr11:494944 RNH1 0.6 6.47 0.33 3.42e-10 Body mass index; LUSC cis rs7246657 0.943 rs3760825 chr19:37945601 C/T cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg08462924 chr1:41848221 NA 0.49 8.26 0.41 3.55e-15 Intelligence (multi-trait analysis); LUSC cis rs60843830 1.000 rs9213 chr2:218386 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 8.09 0.4 1.15e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs2243480 1.000 rs6958289 chr7:65657111 T/G cg10756647 chr7:56101905 PSPH -0.86 -8.54 -0.42 4.98e-16 Diabetic kidney disease; LUSC trans rs62103177 0.714 rs12607447 chr18:77605212 A/G cg05926928 chr17:57297772 GDPD1 1.07 13.14 0.58 4.62e-32 Opioid sensitivity; LUSC cis rs4664304 0.900 rs62176692 chr2:160743463 C/T cg23995753 chr2:160760732 LY75 -0.32 -5.99 -0.31 5.5e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6547741 0.788 rs7595739 chr2:27874563 G/T cg27432699 chr2:27873401 GPN1 -0.88 -17.51 -0.69 3.63e-49 Oral cavity cancer; LUSC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg05585544 chr11:47624801 NA -0.33 -5.99 -0.31 5.37e-9 Subjective well-being; LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg22868518 chr11:507468 RNH1 -0.65 -6.08 -0.32 3.34e-9 Body mass index; LUSC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg13206674 chr6:150067644 NUP43 0.62 9.92 0.48 1.7e-20 Lung cancer; LUSC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg22800045 chr5:56110881 MAP3K1 0.45 6.36 0.33 6.68e-10 Breast cancer;Breast cancer (early onset); LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.49 -8.47 -0.42 8.09e-16 Lymphocyte counts; LUSC cis rs17826219 0.706 rs9893922 chr17:29068425 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Body mass index; LUSC cis rs950776 0.518 rs12902493 chr15:78819275 C/G cg06917634 chr15:78832804 PSMA4 0.83 15.05 0.64 1.87e-39 Sudden cardiac arrest; LUSC cis rs7903847 0.667 rs3818787 chr10:99145179 T/C cg08345082 chr10:99160200 RRP12 -0.36 -7.37 -0.37 1.31e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs11190604 1.000 rs7073586 chr10:102307671 A/G cg23241863 chr10:102295624 HIF1AN 0.47 6.0 0.31 5.01e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.0 0.31 5.03e-9 Personality dimensions; LUSC cis rs7923837 0.574 rs2488075 chr10:94490174 T/C cg25093409 chr10:94429542 NA -0.35 -5.93 -0.31 7.46e-9 Body mass index;Multiple sclerosis; LUSC cis rs8017423 0.904 rs7147212 chr14:90697809 A/C cg14092571 chr14:90743983 NA -0.36 -5.99 -0.31 5.35e-9 Mortality in heart failure; LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11060661 chr22:24314208 DDT;DDTL -0.41 -6.88 -0.35 3.03e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4664308 0.840 rs1870102 chr2:161070582 A/G cg03641300 chr2:160917029 PLA2R1 -0.62 -10.55 -0.5 1.21e-22 Idiopathic membranous nephropathy; LUSC cis rs4499344 0.604 rs259275 chr19:33159693 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.75 11.51 0.53 4.84e-26 Mean platelet volume; LUSC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.18 0.49 2.32e-21 Electroencephalogram traits; LUSC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg16262614 chr3:133464971 TF 0.42 7.19 0.37 4.19e-12 Iron status biomarkers (transferrin levels); LUSC cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg12386194 chr3:101231763 SENP7 0.56 7.61 0.38 2.8e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2408955 0.504 rs11168441 chr12:48576054 G/A cg24011408 chr12:48396354 COL2A1 0.41 5.86 0.31 1.13e-8 Glycated hemoglobin levels; LUSC cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg22508957 chr16:3507546 NAT15 0.42 6.02 0.31 4.59e-9 Body mass index (adult); LUSC cis rs1018836 0.608 rs1033347 chr8:91464137 G/A cg16814680 chr8:91681699 NA -0.52 -7.56 -0.38 3.97e-13 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg26338869 chr17:61819248 STRADA 0.41 5.81 0.3 1.49e-8 Prudent dietary pattern; LUSC cis rs113835537 0.529 rs11227515 chr11:66287383 C/T cg24851651 chr11:66362959 CCS 0.53 8.06 0.4 1.33e-14 Airway imaging phenotypes; LUSC cis rs3820928 0.967 rs16822905 chr2:227770727 G/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.84 -0.39 5.95e-14 Pulmonary function; LUSC cis rs1215050 0.791 rs155019 chr4:98759126 G/A cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.25e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1153858 1.000 rs28679834 chr15:45616206 C/T cg26924012 chr15:45694286 SPATA5L1 1.15 20.56 0.75 2.89e-61 Homoarginine levels; LUSC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg24675658 chr1:53192096 ZYG11B -0.6 -9.25 -0.45 2.67e-18 Monocyte count; LUSC cis rs75920871 0.528 rs983567 chr11:116783600 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.47 -5.96 -0.31 6.54e-9 Subjective well-being; LUSC cis rs7904368 0.806 rs7899853 chr10:16857603 A/T cg23933602 chr10:16859644 RSU1 0.5 6.01 0.31 4.84e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg02931644 chr1:25747376 RHCE -0.31 -5.66 -0.3 3.33e-8 Erythrocyte sedimentation rate; LUSC trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg15704280 chr7:45808275 SEPT13 -0.45 -6.3 -0.33 9.59e-10 Height; LUSC cis rs897984 0.511 rs7196726 chr16:31092075 G/A cg02466173 chr16:30829666 NA -0.49 -9.38 -0.46 1.07e-18 Dementia with Lewy bodies; LUSC cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg25427524 chr10:38739819 LOC399744 -0.6 -10.74 -0.51 2.63e-23 Extrinsic epigenetic age acceleration; LUSC cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg05347473 chr6:146136440 FBXO30 0.59 10.6 0.5 8.2000000000000006e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg15445000 chr17:37608096 MED1 0.38 6.63 0.34 1.34e-10 Glomerular filtration rate (creatinine); LUSC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg25767906 chr1:53392781 SCP2 -0.34 -5.69 -0.3 2.72e-8 Monocyte count; LUSC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.24 0.45 2.94e-18 Total body bone mineral density; LUSC cis rs1538970 1.000 rs7417107 chr1:45831915 G/C cg05343316 chr1:45956843 TESK2 0.58 8.08 0.4 1.22e-14 Platelet count; LUSC cis rs10782582 0.593 rs17585530 chr1:76134990 G/A cg10523679 chr1:76189770 ACADM -0.49 -7.11 -0.36 6.92e-12 Daytime sleep phenotypes; LUSC cis rs4969178 0.965 rs56658017 chr17:76396164 G/A cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg22907277 chr7:1156413 C7orf50 0.38 5.86 0.31 1.11e-8 Longevity;Endometriosis; LUSC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -8.27 -0.41 3.23e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg23711669 chr6:146136114 FBXO30 0.78 12.85 0.58 5.36e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs909341 0.859 rs2297441 chr20:62327582 A/G cg09650180 chr20:62225654 GMEB2 -0.47 -6.15 -0.32 2.19e-9 Atopic dermatitis; LUSC cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg00071950 chr4:10020882 SLC2A9 -0.49 -8.17 -0.41 6.57e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7824557 0.815 rs2572430 chr8:11105304 G/T cg08975724 chr8:8085496 FLJ10661 0.45 6.4 0.33 5.23e-10 Retinal vascular caliber; LUSC cis rs9311676 0.656 rs11714807 chr3:58405431 A/G cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.1e-10 Systemic lupus erythematosus; LUSC cis rs7572644 0.713 rs11127129 chr2:28076708 C/G cg27432699 chr2:27873401 GPN1 -0.53 -6.98 -0.36 1.63e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs10832963 0.961 rs10832954 chr11:18643559 G/A cg09201001 chr11:18656081 SPTY2D1 0.92 15.07 0.64 1.57e-39 Breast cancer; LUSC cis rs193541 0.530 rs2045626 chr5:122081253 A/C cg19077854 chr5:122220652 SNX24 0.34 7.14 0.36 5.93e-12 Glucose homeostasis traits; LUSC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs7954584 0.635 rs7313252 chr12:122347600 G/A cg10207240 chr12:122356781 WDR66 0.45 6.51 0.34 2.83e-10 Mean corpuscular volume; LUSC cis rs13401104 0.633 rs11679598 chr2:237112451 A/C cg19324714 chr2:237145437 ASB18 0.43 5.76 0.3 1.94e-8 Educational attainment; LUSC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg11812906 chr14:75593930 NEK9 0.4 5.91 0.31 8.27e-9 Caffeine consumption; LUSC cis rs11032090 1 rs11032090 chr11:4417129 A/G cg09983885 chr11:4415245 TRIM21 0.56 9.34 0.46 1.41e-18 Lung cancer; LUSC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg01097406 chr16:89675127 NA -0.34 -6.72 -0.34 8.09e-11 Vitiligo; LUSC cis rs4363385 0.818 rs1334848 chr1:153004721 A/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.46e-8 Inflammatory skin disease; LUSC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg14784868 chr12:69753453 YEATS4 0.61 9.05 0.44 1.18e-17 Blood protein levels; LUSC cis rs7246967 0.611 rs3902164 chr19:22866281 T/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg22467129 chr15:76604101 ETFA -0.51 -8.29 -0.41 2.77e-15 Blood metabolite levels; LUSC cis rs4478858 0.684 rs10753245 chr1:31731208 A/G cg00250761 chr1:31883323 NA -0.34 -8.37 -0.42 1.58e-15 Alcohol dependence; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.97 0.31 5.94e-9 Renal function-related traits (BUN); LUSC trans rs6598955 0.671 rs11247896 chr1:26600483 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.53 -0.42 5.13e-16 Obesity-related traits; LUSC trans rs1908814 0.516 rs7812563 chr8:11794488 T/G cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.76e-9 Neuroticism; LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.59 -0.5 8.72e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg04287289 chr16:89883240 FANCA -0.41 -5.95 -0.31 6.6e-9 Vitiligo; LUSC cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 3.93e-12 Motion sickness; LUSC cis rs9905704 0.624 rs8080071 chr17:57093825 C/T cg05425664 chr17:57184151 TRIM37 0.48 7.23 0.37 3.4e-12 Testicular germ cell tumor; LUSC trans rs79976124 0.800 rs12194767 chr6:66639599 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 8.58 0.42 3.62e-16 Type 2 diabetes; LUSC cis rs4654899 0.758 rs7530739 chr1:21447480 C/A cg01072550 chr1:21505969 NA -0.52 -8.05 -0.4 1.46e-14 Superior frontal gyrus grey matter volume; LUSC cis rs9323205 0.577 rs9672038 chr14:51724856 A/G cg23942311 chr14:51606299 NA -0.42 -9.08 -0.44 9.68e-18 Cancer; LUSC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg11344533 chr11:111475393 SIK2 -0.49 -6.81 -0.35 4.52e-11 Primary sclerosing cholangitis; LUSC cis rs2694528 0.623 rs1563517 chr5:60063511 A/C cg11474532 chr5:59995715 DEPDC1B -0.65 -7.19 -0.37 4.19e-12 Parkinson's disease; LUSC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg02428538 chr16:24856791 SLC5A11 -0.44 -5.69 -0.3 2.76e-8 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.7 -0.43 1.5e-16 Axial length; LUSC trans rs11098499 0.754 rs10212714 chr4:120254302 T/C cg25214090 chr10:38739885 LOC399744 0.42 6.42 0.33 4.6e-10 Corneal astigmatism; LUSC cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg04586622 chr2:25135609 ADCY3 0.4 8.45 0.42 9.14e-16 Body mass index; LUSC cis rs9650657 0.513 rs7005884 chr8:10796472 A/G cg27411982 chr8:10470053 RP1L1 -0.47 -7.55 -0.38 4.23e-13 Neuroticism; LUSC cis rs9534288 0.830 rs2897027 chr13:46636235 A/G cg15192986 chr13:46630673 CPB2 -0.81 -12.51 -0.57 9.9e-30 Blood protein levels; LUSC cis rs7296418 0.961 rs11608811 chr12:123529056 A/G cg05973401 chr12:123451056 ABCB9 0.65 9.62 0.47 1.71e-19 Platelet count; LUSC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg08499158 chr17:42289980 UBTF 0.39 6.1 0.32 2.97e-9 Total body bone mineral density; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg11905131 chr22:24372483 LOC391322 -0.58 -9.61 -0.47 1.78e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg22875332 chr1:76189707 ACADM 0.83 14.07 0.61 1.27e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs709400 0.663 rs62007719 chr14:103943130 G/T cg10523860 chr14:103875565 MARK3 -0.38 -6.03 -0.31 4.44e-9 Body mass index; LUSC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs1865760 1.000 rs12209482 chr6:25909229 T/G cg16482183 chr6:26056742 HIST1H1C 0.44 6.59 0.34 1.72e-10 Height; LUSC cis rs7666738 0.546 rs28590002 chr4:98722642 C/T cg17366294 chr4:99064904 C4orf37 0.54 8.56 0.42 4.08e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg03609598 chr5:56110824 MAP3K1 -0.41 -5.9 -0.31 8.97e-9 Initial pursuit acceleration; LUSC cis rs6696846 0.749 rs7515178 chr1:205084120 G/A cg00857998 chr1:205179979 DSTYK 0.62 9.92 0.48 1.67e-20 Red blood cell count; LUSC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg13298116 chr11:62369859 EML3;MTA2 0.61 9.71 0.47 8.33e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg03060546 chr3:49711283 APEH 0.65 6.99 0.36 1.46e-11 Menarche (age at onset); LUSC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg16423285 chr20:60520624 NA -0.46 -5.86 -0.31 1.12e-8 Body mass index; LUSC cis rs644799 0.601 rs662168 chr11:95586982 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.69 10.32 0.49 7.69e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3540 0.533 rs1869179 chr15:90895564 A/C cg22089800 chr15:90895588 ZNF774 0.67 10.71 0.51 3.27e-23 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4664304 0.802 rs17830307 chr2:160871799 T/C cg23995753 chr2:160760732 LY75 -0.34 -6.4 -0.33 5.23e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs12310956 0.532 rs11052930 chr12:33964824 A/G cg13010199 chr12:38710504 ALG10B 0.56 8.46 0.42 8.59e-16 Morning vs. evening chronotype; LUSC cis rs6987853 0.787 rs2923427 chr8:42385748 A/C cg09913449 chr8:42400586 C8orf40 0.54 9.26 0.45 2.61e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.94 -0.44 2.75e-17 Breast cancer; LUSC cis rs314370 1.000 rs314370 chr7:100453208 T/C cg08558340 chr7:100472263 SRRT 0.52 6.49 0.33 3.13e-10 Resting heart rate; LUSC cis rs11122272 0.735 rs2491405 chr1:231513431 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7809950 0.954 rs2520245 chr7:107137428 G/C cg23024343 chr7:107201750 COG5 -0.55 -8.73 -0.43 1.26e-16 Coronary artery disease; LUSC cis rs8028313 0.731 rs4776964 chr15:68016955 T/G cg05925327 chr15:68127851 NA -0.4 -6.27 -0.32 1.09e-9 Obesity; LUSC cis rs10904908 1.000 rs7920002 chr10:17259766 T/A cg01003015 chr10:17271136 VIM -0.43 -6.17 -0.32 2e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs997295 0.504 rs12905397 chr15:68034150 T/C cg08079166 chr15:68083412 MAP2K5 -0.38 -7.75 -0.39 1.11e-13 Motion sickness; LUSC trans rs6480314 0.542 rs61854816 chr10:70028808 C/T cg04882175 chr6:131122610 NA -0.54 -6.32 -0.33 8.24e-10 Optic nerve measurement (disc area); LUSC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg01475377 chr6:109611718 NA -0.38 -6.75 -0.35 6.74e-11 Reticulocyte fraction of red cells; LUSC cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs826838 0.616 rs10880738 chr12:38617762 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.45 -0.42 8.99e-16 Heart rate; LUSC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg15744005 chr10:104629667 AS3MT -0.29 -6.28 -0.33 1.04e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs7824557 0.606 rs2736273 chr8:11199938 C/A cg08975724 chr8:8085496 FLJ10661 0.49 6.98 0.36 1.61e-11 Retinal vascular caliber; LUSC cis rs7760535 0.794 rs463860 chr6:111691721 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -7.01 -0.36 1.36e-11 Metabolic traits; LUSC cis rs4474465 0.850 rs7938257 chr11:78224908 A/G cg27205649 chr11:78285834 NARS2 0.54 6.14 0.32 2.36e-9 Alzheimer's disease (survival time); LUSC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC trans rs61931739 0.517 rs7958856 chr12:34294737 T/C cg13010199 chr12:38710504 ALG10B 0.53 8.24 0.41 4.01e-15 Morning vs. evening chronotype; LUSC cis rs9486719 1.000 rs3798295 chr6:97052164 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -10.08 -0.48 4.76e-21 Migraine;Coronary artery disease; LUSC cis rs7560272 0.538 rs2001436 chr2:73928965 A/T cg20560298 chr2:73613845 ALMS1 0.38 5.84 0.3 1.22e-8 Schizophrenia; LUSC cis rs708547 0.915 rs28605409 chr4:57766261 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.54 6.5 0.34 2.86e-10 Response to bleomycin (chromatid breaks); LUSC trans rs6600671 1.000 rs2185281 chr1:121179991 A/G cg00646200 chr1:148855367 NA 0.45 7.09 0.36 8.01e-12 Hip geometry; LUSC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg12826209 chr6:26865740 GUSBL1 0.75 9.06 0.44 1.16e-17 Intelligence (multi-trait analysis); LUSC cis rs3857067 0.806 rs9307137 chr4:95135712 T/C cg11021082 chr4:95130006 SMARCAD1 -0.32 -5.69 -0.3 2.78e-8 QT interval; LUSC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg14668632 chr7:2872130 GNA12 -0.43 -6.37 -0.33 6.22e-10 Height; LUSC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg06221963 chr1:154839813 KCNN3 -0.66 -15.73 -0.65 4.11e-42 Prostate cancer; LUSC cis rs6582630 0.554 rs7299735 chr12:38450890 A/C cg13010199 chr12:38710504 ALG10B -0.44 -6.66 -0.34 1.15e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs11098499 0.866 rs9991221 chr4:120292107 G/C cg09307838 chr4:120376055 NA 0.69 10.35 0.49 5.71e-22 Corneal astigmatism; LUSC cis rs3770081 0.793 rs60719866 chr2:86284378 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.99 -0.36 1.51e-11 Facial emotion recognition (sad faces); LUSC cis rs273573 1.000 rs273604 chr11:30966112 G/A cg14844989 chr11:31128820 NA 0.37 5.89 0.31 9.5e-9 Total body bone mineral density; LUSC cis rs2274459 0.749 rs2281831 chr6:33695815 G/A cg06253072 chr6:33679850 C6orf125 0.48 5.9 0.31 9.13e-9 Obesity (extreme); LUSC cis rs4478858 0.775 rs6701667 chr1:31707971 A/C cg00250761 chr1:31883323 NA -0.35 -9.25 -0.45 2.79e-18 Alcohol dependence; LUSC cis rs146817970 1 rs146817970 chr5:81512947 TA/T cg15871215 chr5:81402204 ATG10 -0.45 -6.62 -0.34 1.47e-10 Breast cancer; LUSC cis rs2742417 1.000 rs1877932 chr3:45753539 A/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2742417 0.967 rs9825559 chr3:45740278 T/C cg04837898 chr3:45731254 SACM1L -0.35 -5.66 -0.3 3.31e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.93 0.48 1.52e-20 Bipolar disorder; LUSC cis rs9467711 0.606 rs9358936 chr6:26370657 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs3808502 0.549 rs11991139 chr8:11428395 C/T cg06636001 chr8:8085503 FLJ10661 -0.63 -9.41 -0.46 8.22e-19 Neuroticism; LUSC cis rs6545883 0.868 rs2518933 chr2:61797030 C/A cg15711740 chr2:61764176 XPO1 -0.46 -7.38 -0.37 1.3e-12 Tuberculosis; LUSC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg05528280 chr10:464225 DIP2C 0.39 6.0 0.31 5.23e-9 Psychosis in Alzheimer's disease; LUSC cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg04586622 chr2:25135609 ADCY3 0.43 9.23 0.45 3.12e-18 Body mass index; LUSC cis rs9303401 0.659 rs12602808 chr17:56698420 A/G cg25039879 chr17:56429692 SUPT4H1 0.64 8.67 0.43 1.92e-16 Cognitive test performance; LUSC cis rs6977660 1.000 rs13230910 chr7:19806003 A/G cg07541023 chr7:19748670 TWISTNB -0.53 -6.08 -0.32 3.3e-9 Thyroid stimulating hormone; LUSC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg07685180 chr8:600429 NA -0.66 -6.53 -0.34 2.44e-10 IgG glycosylation; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg07677032 chr17:61819896 STRADA 0.54 8.94 0.44 2.72e-17 Prudent dietary pattern; LUSC cis rs11608355 0.515 rs12831026 chr12:109903651 C/T cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg08355456 chr11:67383691 NA 0.47 9.34 0.46 1.39e-18 Mean corpuscular volume; LUSC cis rs2637266 0.777 rs2637254 chr10:78312002 G/A cg18941641 chr10:78392320 NA 0.39 7.01 0.36 1.36e-11 Pulmonary function; LUSC trans rs9944715 1.000 rs9944715 chr18:43831259 A/G cg01718231 chr17:29326311 RNF135 -0.5 -7.12 -0.36 6.79e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.12 0.52 1.19e-24 Colorectal cancer; LUSC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg14440974 chr22:39074834 NA -0.4 -6.75 -0.35 6.63e-11 Menopause (age at onset); LUSC cis rs7523050 0.643 rs36052234 chr1:109402943 C/T cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg26061582 chr7:22766209 IL6 0.48 6.91 0.35 2.51e-11 Lung cancer; LUSC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg20135002 chr11:47629003 NA -0.53 -8.25 -0.41 3.67e-15 Subjective well-being; LUSC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg02896835 chr1:92012615 NA -0.65 -11.83 -0.54 3.3e-27 Breast cancer; LUSC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.74 11.02 0.52 2.64e-24 Multiple sclerosis; LUSC cis rs9303401 0.580 rs2013166 chr17:56637630 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg04469686 chr1:162760199 HSD17B7 -0.47 -6.77 -0.35 5.87e-11 Breast cancer; LUSC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg12615879 chr12:58013172 SLC26A10 -0.28 -5.81 -0.3 1.49e-8 Multiple sclerosis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg09000178 chr16:67063319 CBFB 0.43 6.77 0.35 5.84e-11 Triglycerides; LUSC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg18240062 chr17:79603768 NPLOC4 0.79 15.29 0.64 2.32e-40 Eye color traits; LUSC cis rs4423214 0.592 rs78300366 chr11:71205514 A/G cg05163923 chr11:71159392 DHCR7 -0.68 -7.11 -0.36 7.22e-12 Vitamin D levels; LUSC trans rs9401746 0.564 rs671820 chr6:124796163 T/A cg16857858 chr7:27213984 HOXA10 0.55 6.28 0.32 1.08e-9 Bone mineral density (Ward's triangle area); LUSC cis rs2124969 0.522 rs6432608 chr2:161034991 C/T cg03641300 chr2:160917029 PLA2R1 -0.46 -7.35 -0.37 1.57e-12 Waist circumference adjusted for body mass index; LUSC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.94 0.36 2.05e-11 Cystic fibrosis severity; LUSC trans rs6598955 0.671 rs10902735 chr1:26617936 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.28 -0.41 2.95e-15 Obesity-related traits; LUSC cis rs955333 0.925 rs1533746 chr6:154929308 G/A cg20019720 chr6:154832845 CNKSR3 0.47 5.84 0.3 1.23e-8 Diabetic kidney disease; LUSC cis rs62400317 0.762 rs12209944 chr6:44788156 G/C cg20913747 chr6:44695427 NA -0.48 -7.12 -0.36 6.56e-12 Total body bone mineral density; LUSC cis rs7267979 0.764 rs2474767 chr20:25246733 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.73 14.75 0.63 2.86e-38 Liver enzyme levels (alkaline phosphatase); LUSC cis rs929596 0.785 rs34352510 chr2:234650562 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.69 -11.98 -0.55 9.48e-28 Total bilirubin levels in HIV-1 infection; LUSC cis rs714027 0.546 rs5763614 chr22:30331290 A/G cg11564601 chr22:30592435 NA 0.34 5.77 0.3 1.83e-8 Lymphocyte counts; LUSC cis rs6121246 0.529 rs2889528 chr20:30210021 C/T cg21427119 chr20:30132790 HM13 -0.43 -6.1 -0.32 3.01e-9 Mean corpuscular hemoglobin; LUSC cis rs11209002 0.614 rs4655515 chr1:67566898 T/C cg02640540 chr1:67518911 SLC35D1 0.63 8.8 0.43 7.73e-17 Crohn's disease; LUSC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 7.33 0.37 1.78e-12 Personality dimensions; LUSC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg05082376 chr22:42548792 NA -0.43 -6.48 -0.33 3.36e-10 Schizophrenia; LUSC trans rs3733585 0.579 rs4235356 chr4:10123106 G/C cg26043149 chr18:55253948 FECH -0.53 -7.78 -0.39 9.38e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.06 0.31 3.64e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg06238570 chr21:40685208 BRWD1 -0.59 -9.9 -0.48 2.04e-20 Cognitive function; LUSC cis rs68170813 0.559 rs74584447 chr7:106944755 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.7 -0.47 8.88e-20 Coronary artery disease; LUSC cis rs7582180 0.903 rs13031712 chr2:100896512 G/A cg08017756 chr2:100939284 LONRF2 -0.36 -6.01 -0.31 4.77e-9 Intelligence (multi-trait analysis); LUSC cis rs8014204 0.935 rs10141438 chr14:75354600 A/G cg06637938 chr14:75390232 RPS6KL1 -0.67 -11.3 -0.53 2.66e-25 Caffeine consumption; LUSC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg11645453 chr3:52864694 ITIH4 0.34 8.14 0.41 7.76e-15 Bipolar disorder; LUSC cis rs9398803 0.965 rs9388490 chr6:126704795 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.96e-9 Male-pattern baldness; LUSC cis rs3820068 0.705 rs4646063 chr1:15829813 G/A cg17385448 chr1:15911702 AGMAT 0.4 6.11 0.32 2.83e-9 Systolic blood pressure; LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg04944784 chr2:26401820 FAM59B 0.78 11.21 0.52 5.48e-25 Gut microbiome composition (summer); LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg00166722 chr3:10149974 C3orf24 0.57 7.28 0.37 2.43e-12 Alzheimer's disease; LUSC trans rs2204008 0.775 rs3900361 chr12:38238936 A/G cg06521331 chr12:34319734 NA 0.43 6.7 0.34 8.88e-11 Bladder cancer; LUSC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg04317338 chr11:64019027 PLCB3 0.64 7.33 0.37 1.77e-12 Mean platelet volume; LUSC cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg09184832 chr6:79620586 NA -0.44 -7.09 -0.36 8.02e-12 Intelligence (multi-trait analysis); LUSC cis rs7818345 0.967 rs4433156 chr8:19284247 A/C cg11303988 chr8:19266685 CSGALNACT1 0.38 7.36 0.37 1.43e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg02466173 chr16:30829666 NA -0.59 -10.99 -0.52 3.56e-24 Multiple myeloma; LUSC trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg15704280 chr7:45808275 SEPT13 -0.58 -7.16 -0.36 5.02e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg23758822 chr17:41437982 NA -0.97 -17.29 -0.69 2.87e-48 Menopause (age at onset); LUSC cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg15557168 chr22:42548783 NA 0.35 5.84 0.3 1.25e-8 Cognitive function; LUSC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg16624210 chr5:671434 TPPP 0.5 6.47 0.33 3.58e-10 Obesity-related traits; LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.06 -0.36 9.55e-12 Bipolar disorder; LUSC cis rs2979489 0.533 rs62505279 chr8:30447069 C/T cg26383811 chr8:30366931 RBPMS -0.46 -7.38 -0.37 1.29e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 3.1e-34 Prudent dietary pattern; LUSC cis rs9467711 0.516 rs1177441 chr6:25859413 A/G cg08501292 chr6:25962987 TRIM38 0.57 5.8 0.3 1.53e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7561273 0.609 rs2160943 chr2:24288775 G/A cg06627628 chr2:24431161 ITSN2 -0.51 -6.83 -0.35 3.93e-11 Quantitative traits; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg05025164 chr4:1340916 KIAA1530 0.42 6.45 0.33 3.96e-10 Obesity-related traits; LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.39 0.33 5.73e-10 Menopause (age at onset); LUSC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg09323728 chr8:95962352 TP53INP1 -0.45 -9.18 -0.45 4.76e-18 Type 2 diabetes; LUSC trans rs72674100 1.000 rs28520218 chr4:97966557 T/C cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg01738412 chr7:87505461 SLC25A40;DBF4 0.39 6.01 0.31 4.99e-9 Schizophrenia; LUSC cis rs921968 0.643 rs471846 chr2:219432237 C/T cg02176678 chr2:219576539 TTLL4 0.61 11.04 0.52 2.37e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs9807989 0.839 rs10204837 chr2:102977730 C/A cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.98 0.31 5.66e-9 Intelligence (multi-trait analysis); LUSC cis rs3540 0.576 rs12907587 chr15:91045851 G/C cg22089800 chr15:90895588 ZNF774 -0.64 -9.53 -0.46 3.44e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs3858145 0.588 rs61854831 chr10:70035837 C/T cg04882175 chr6:131122610 NA -0.65 -8.71 -0.43 1.4e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC cis rs2404602 0.569 rs283793 chr15:76774752 G/A cg23625390 chr15:77176239 SCAPER 0.53 7.63 0.39 2.41e-13 Blood metabolite levels; LUSC cis rs10186029 0.708 rs4672673 chr2:213981463 A/G cg08319019 chr2:214017104 IKZF2 0.6 8.62 0.43 2.73e-16 Systemic sclerosis; LUSC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg10523679 chr1:76189770 ACADM 0.86 12.77 0.57 1.13e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17030434 0.906 rs78436201 chr4:154661755 C/A cg14289246 chr4:154710475 SFRP2 -0.56 -7.22 -0.37 3.64e-12 Electrocardiographic conduction measures; LUSC cis rs11122272 0.735 rs2572263 chr1:231509408 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.75 0.3 2.05e-8 Personality dimensions; LUSC cis rs11229555 0.645 rs11229435 chr11:58185796 G/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2637266 1.000 rs7474960 chr10:78359021 C/T cg18941641 chr10:78392320 NA 0.39 7.41 0.38 1.02e-12 Pulmonary function; LUSC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg12756686 chr19:29218302 NA 0.56 6.74 0.35 6.93e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs8077889 0.956 rs6503476 chr17:41850163 C/T cg26893861 chr17:41843967 DUSP3 0.96 15.09 0.64 1.36e-39 Triglycerides; LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg16615211 chr3:44902933 MIR564;TMEM42 0.39 7.05 0.36 1.05e-11 Depressive symptoms; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg20591408 chr2:241516333 RNPEPL1 0.45 6.55 0.34 2.17e-10 Cognitive function;Information processing speed; LUSC cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg03264133 chr6:25882463 NA 0.61 10.28 0.49 1.03e-21 Blood metabolite levels; LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg14004847 chr7:1930337 MAD1L1 -0.45 -6.58 -0.34 1.81e-10 Bipolar disorder and schizophrenia; LUSC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg18904891 chr8:8559673 CLDN23 0.56 7.71 0.39 1.42e-13 Obesity-related traits; LUSC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg09877947 chr5:131593287 PDLIM4 0.37 6.23 0.32 1.39e-9 Breast cancer;Mosquito bite size; LUSC cis rs6782228 0.585 rs9841161 chr3:128331870 A/G cg16766828 chr3:128327626 NA -0.32 -5.84 -0.3 1.25e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg25767906 chr1:53392781 SCP2 -0.48 -8.74 -0.43 1.13e-16 Monocyte count; LUSC cis rs9660992 0.649 rs72745216 chr1:205261016 G/A cg21545522 chr1:205238299 TMCC2 0.5 9.45 0.46 5.97e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9616064 0.506 rs2542038 chr22:47059282 C/T cg25730555 chr22:47059586 GRAMD4 0.45 7.82 0.39 7.06e-14 Urate levels in obese individuals; LUSC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg18252515 chr7:66147081 NA -1.23 -13.58 -0.6 9.14e-34 Diabetic kidney disease; LUSC cis rs4285028 0.948 rs34478505 chr3:121694071 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.71 -9.34 -0.46 1.36e-18 Multiple sclerosis; LUSC cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg23992470 chr4:843637 GAK 0.6 6.41 0.33 5.02e-10 Intelligence (multi-trait analysis); LUSC cis rs72772090 0.539 rs17481759 chr5:96114695 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.87 -0.35 3.07e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.66 0.34 1.15e-10 Menopause (age at onset); LUSC cis rs10782582 0.593 rs6673786 chr1:76149637 C/T cg03433033 chr1:76189801 ACADM -0.44 -6.47 -0.33 3.43e-10 Daytime sleep phenotypes; LUSC cis rs1775715 0.769 rs2799030 chr10:32172935 G/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.65 0.34 1.19e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7089973 0.584 rs6585300 chr10:116639889 A/C cg03647239 chr10:116582469 FAM160B1 0.45 7.12 0.36 6.47e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9479482 1.000 rs9479482 chr6:150358012 T/C cg00432049 chr6:150390894 ULBP3 -0.27 -5.68 -0.3 2.86e-8 Alopecia areata; LUSC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.4 -0.33 5.18e-10 Breast cancer; LUSC trans rs7824557 0.628 rs34237267 chr8:11197301 G/C cg08975724 chr8:8085496 FLJ10661 0.43 6.2 0.32 1.62e-9 Retinal vascular caliber; LUSC cis rs2730245 0.527 rs2730237 chr7:158706166 A/G cg11984989 chr7:158649758 WDR60 1.04 13.31 0.59 1e-32 Height; LUSC cis rs7107174 0.892 rs11601195 chr11:78073501 A/G cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.08 14.54 0.62 1.89e-37 Gut microbiome composition (summer); LUSC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg23758822 chr17:41437982 NA -1.0 -19.95 -0.74 7.3e-59 Menopause (age at onset); LUSC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs921968 0.643 rs589967 chr2:219445165 T/C cg02176678 chr2:219576539 TTLL4 0.64 11.82 0.54 3.7e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg13395646 chr4:1353034 KIAA1530 -0.56 -8.6 -0.43 3.26e-16 Obesity-related traits; LUSC cis rs700651 0.856 rs9288280 chr2:198744324 A/G cg00792783 chr2:198669748 PLCL1 0.45 5.98 0.31 5.69e-9 Intracranial aneurysm; LUSC cis rs701145 0.585 rs1727949 chr3:153875713 A/G cg17054900 chr3:154042577 DHX36 0.58 5.93 0.31 7.52e-9 Coronary artery disease; LUSC trans rs9944715 1.000 rs12605945 chr18:43834118 A/G cg01718231 chr17:29326311 RNF135 -0.5 -6.97 -0.36 1.71e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs10782582 0.593 rs77208152 chr1:76124255 T/C cg22875332 chr1:76189707 ACADM -0.42 -6.24 -0.32 1.35e-9 Daytime sleep phenotypes; LUSC cis rs6845621 0.727 rs10032307 chr4:18911775 T/C cg12196642 chr4:18937545 NA -0.34 -6.3 -0.33 9.55e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.36 0.33 6.53e-10 Mean platelet volume; LUSC cis rs2404602 0.692 rs55864032 chr15:77122548 A/G cg22467129 chr15:76604101 ETFA -0.44 -6.92 -0.35 2.29e-11 Blood metabolite levels; LUSC cis rs6456156 0.586 rs720325 chr6:167467349 G/T cg07741184 chr6:167504864 NA 0.4 6.95 0.36 1.91e-11 Primary biliary cholangitis; LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg27284194 chr4:1044797 NA 0.35 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs868036 0.681 rs2241423 chr15:68086838 G/A cg08079166 chr15:68083412 MAP2K5 0.41 7.46 0.38 7.5e-13 Restless legs syndrome; LUSC cis rs4474465 1.000 rs7395344 chr11:78202388 A/G cg27205649 chr11:78285834 NARS2 -0.5 -5.98 -0.31 5.76e-9 Alzheimer's disease (survival time); LUSC cis rs11690935 0.885 rs6750058 chr2:172786909 G/T cg13550731 chr2:172543902 DYNC1I2 -0.8 -12.74 -0.57 1.47e-30 Schizophrenia; LUSC cis rs9581857 0.579 rs7332104 chr13:27957831 C/G cg22138327 chr13:27999177 GTF3A -0.63 -7.44 -0.38 8.83e-13 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs11971779 0.680 rs2355783 chr7:139075879 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg12927641 chr6:109611667 NA -0.43 -7.58 -0.38 3.41e-13 Reticulocyte fraction of red cells; LUSC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg17264618 chr3:40429014 ENTPD3 0.28 6.08 0.32 3.22e-9 Renal cell carcinoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01525244 chr22:39548611 CBX7 0.57 9.23 0.45 3.17e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg05340658 chr4:99064831 C4orf37 0.6 10.21 0.49 1.82e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs2197308 0.765 rs11182434 chr12:37923968 C/A cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg25124228 chr12:125621409 AACS -0.59 -9.9 -0.48 1.99e-20 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg00033643 chr7:134001901 SLC35B4 0.46 7.11 0.36 7e-12 Mean platelet volume; LUSC cis rs7824557 0.583 rs2736292 chr8:11234500 A/T cg21775007 chr8:11205619 TDH 0.65 10.49 0.5 1.95e-22 Retinal vascular caliber; LUSC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg03676636 chr4:99064102 C4orf37 0.36 7.7 0.39 1.5700000000000001e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3015497 0.753 rs12881776 chr14:51136330 T/G cg26011998 chr14:51135199 SAV1 -0.39 -5.65 -0.3 3.5e-8 Mean platelet volume; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg12379764 chr21:47803548 PCNT 0.49 7.0 0.36 1.4e-11 Testicular germ cell tumor; LUSC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg04398451 chr17:18023971 MYO15A 0.57 9.53 0.46 3.41e-19 Total body bone mineral density; LUSC cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.83 0.3 1.31e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg02931644 chr1:25747376 RHCE 0.37 7.0 0.36 1.38e-11 Erythrocyte sedimentation rate; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg12463550 chr7:65579703 CRCP 0.57 8.54 0.42 4.77e-16 Aortic root size; LUSC cis rs12421382 0.511 rs2212430 chr11:109289538 C/T cg16359550 chr11:109292809 C11orf87 0.47 7.88 0.4 4.73e-14 Schizophrenia; LUSC cis rs4629180 1.000 rs11123889 chr2:102107180 G/A cg04415270 chr2:102091202 RFX8 0.57 9.22 0.45 3.55e-18 Chronic rhinosinusitis with nasal polyps; LUSC trans rs62238980 0.614 rs55695217 chr22:32463135 C/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs55871839 0.708 rs4738733 chr8:59813760 T/C cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg26384229 chr12:38710491 ALG10B 0.89 15.2 0.64 5.1e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs6546550 0.901 rs12232914 chr2:70117176 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.35 -0.37 1.54e-12 Prevalent atrial fibrillation; LUSC cis rs2273669 0.667 rs11757168 chr6:109301091 A/G cg05315195 chr6:109294784 ARMC2 -0.56 -6.19 -0.32 1.78e-9 Prostate cancer; LUSC cis rs4953318 0.619 rs10198247 chr2:46362677 C/T cg12428440 chr2:46370979 PRKCE -0.47 -7.95 -0.4 2.98e-14 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs865483 0.860 rs853228 chr17:35799889 G/T cg06716730 chr17:35851459 DUSP14 0.27 5.91 0.31 8.66e-9 Monocyte count; LUSC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg07343612 chr16:622815 PIGQ -0.73 -12.51 -0.56 1.07e-29 Height; LUSC trans rs12571093 0.803 rs61854826 chr10:70031558 C/A cg04882175 chr6:131122610 NA -0.55 -6.27 -0.32 1.09e-9 Optic nerve measurement (disc area); LUSC cis rs7215564 0.818 rs34760119 chr17:78604583 G/T cg09596252 chr17:78655493 RPTOR 0.55 6.24 0.32 1.33e-9 Myopia (pathological); LUSC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg18876405 chr7:65276391 NA 0.54 8.33 0.41 2.05e-15 Aortic root size; LUSC cis rs7560272 0.723 rs6729468 chr2:73765253 C/A cg20560298 chr2:73613845 ALMS1 -0.49 -7.6 -0.38 2.92e-13 Schizophrenia; LUSC cis rs3768617 0.610 rs10911228 chr1:183049792 T/C ch.1.3577855R chr1:183094577 LAMC1 0.6 8.64 0.43 2.3e-16 Fuchs's corneal dystrophy; LUSC trans rs9467711 0.524 rs13216484 chr6:26762087 C/T cg06606381 chr12:133084897 FBRSL1 -0.88 -7.56 -0.38 3.87e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs9361491 0.621 rs12196457 chr6:79627743 A/T cg05283184 chr6:79620031 NA -0.45 -8.54 -0.42 4.85e-16 Intelligence (multi-trait analysis); LUSC cis rs2798269 0.646 rs4770182 chr13:22179186 G/T cg18095732 chr13:22033692 ZDHHC20 0.38 6.03 0.31 4.31e-9 PR segment; LUSC cis rs1355223 0.872 rs7116409 chr11:34751007 T/G cg11058730 chr11:34937778 PDHX;APIP -0.39 -5.67 -0.3 3.13e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs10203711 1.000 rs907099 chr2:239559769 G/C cg14580085 chr2:239553406 NA 0.41 6.96 0.36 1.79e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.97 0.31 6.05e-9 Menopause (age at onset); LUSC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.51 -8.7 -0.43 1.55e-16 IgG glycosylation; LUSC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg20607287 chr7:12443886 VWDE -0.65 -6.49 -0.33 3.03e-10 Coronary artery disease; LUSC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg11663144 chr21:46675770 NA -0.41 -7.12 -0.36 6.49e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg11608241 chr8:8085544 FLJ10661 0.43 6.46 0.33 3.78e-10 Systolic blood pressure; LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg08859206 chr1:53392774 SCP2 -0.54 -9.57 -0.46 2.45e-19 Monocyte count; LUSC cis rs34779708 0.931 rs12242882 chr10:35347860 G/C cg03585969 chr10:35415529 CREM 0.6 8.84 0.44 5.75e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg10150615 chr22:24372951 LOC391322 -0.43 -7.07 -0.36 9.39e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7246967 0.673 rs12975767 chr19:22862809 A/C cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs4308124 0.708 rs6727313 chr2:111971540 G/A cg04571233 chr2:111982156 NA -0.52 -6.75 -0.35 6.59e-11 Vitiligo; LUSC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg24531977 chr5:56204891 C5orf35 -1.08 -15.78 -0.65 2.71e-42 Initial pursuit acceleration; LUSC cis rs12928939 0.517 rs8050058 chr16:71981374 T/G cg03805757 chr16:71968109 PKD1L3 -0.62 -9.52 -0.46 3.66e-19 Post bronchodilator FEV1; LUSC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg17366294 chr4:99064904 C4orf37 -0.54 -8.96 -0.44 2.31e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs10740039 0.960 rs10443928 chr10:62405476 A/T cg18175470 chr10:62150864 ANK3 -0.46 -6.86 -0.35 3.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs13082711 0.911 rs57992391 chr3:27511567 A/C cg02860705 chr3:27208620 NA 0.47 7.96 0.4 2.67e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC trans rs6502050 0.835 rs9901076 chr17:80170020 G/A cg07393940 chr7:158741817 NA 0.36 6.41 0.33 5.07e-10 Life satisfaction; LUSC cis rs11640533 1.000 rs11640533 chr16:53412862 A/G cg08681685 chr16:53407594 NA -0.38 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg23711669 chr6:146136114 FBXO30 0.73 12.43 0.56 2.1e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs611744 0.573 rs674580 chr8:109251690 C/G cg18478394 chr8:109455254 TTC35 0.46 7.13 0.36 6.27e-12 Dupuytren's disease; LUSC cis rs2273669 0.667 rs75671532 chr6:109341298 A/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 8.89e-9 Prostate cancer; LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.7 -0.3 2.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1832871 0.711 rs9459924 chr6:158703902 G/A cg07165851 chr6:158734300 TULP4 0.5 7.8 0.39 7.9e-14 Height; LUSC cis rs427941 0.632 rs201478 chr7:101746964 G/C cg06246474 chr7:101738831 CUX1 0.39 6.42 0.33 4.68e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09820084 chr6:18387507 RNF144B 0.49 7.65 0.39 2.17e-13 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9611565 0.569 rs6002328 chr22:41710034 T/C cg03806693 chr22:41940476 POLR3H -0.61 -9.08 -0.44 9.64e-18 Vitiligo; LUSC cis rs12908161 0.959 rs2175567 chr15:85200946 C/G cg17507749 chr15:85114479 UBE2QP1 0.58 7.32 0.37 1.84e-12 Schizophrenia; LUSC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg22800045 chr5:56110881 MAP3K1 0.43 5.9 0.31 8.91e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs9916302 0.752 rs12150047 chr17:37601755 A/G cg07936489 chr17:37558343 FBXL20 -0.81 -9.88 -0.48 2.31e-20 Glomerular filtration rate (creatinine); LUSC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg18252515 chr7:66147081 NA -1.19 -12.9 -0.58 3.46e-31 Diabetic kidney disease; LUSC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg07212818 chr11:638076 DRD4 -0.42 -7.15 -0.36 5.65e-12 Systemic lupus erythematosus; LUSC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.85 0.3 1.2e-8 Tonsillectomy; LUSC cis rs11608355 0.618 rs4486687 chr12:109790741 T/A cg19025524 chr12:109796872 NA -0.48 -9.16 -0.45 5.26e-18 Neuroticism; LUSC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg08048268 chr3:133502702 NA -0.52 -10.37 -0.49 4.91e-22 Iron status biomarkers; LUSC cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg13010199 chr12:38710504 ALG10B 0.67 9.61 0.47 1.83e-19 Bladder cancer; LUSC cis rs6693567 0.565 rs1776276 chr1:150293078 A/C cg15654264 chr1:150340011 RPRD2 0.45 7.27 0.37 2.62e-12 Migraine; LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs4919694 1.000 rs4917988 chr10:104752830 T/G cg04362960 chr10:104952993 NT5C2 1.17 13.66 0.6 4.81e-34 Arsenic metabolism; LUSC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg04871131 chr7:94954202 PON1 -0.39 -6.11 -0.32 2.7e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg00745463 chr17:30367425 LRRC37B -0.8 -9.48 -0.46 4.95e-19 Hip circumference adjusted for BMI; LUSC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg18827107 chr12:86230957 RASSF9 -0.47 -7.14 -0.36 5.93e-12 Major depressive disorder; LUSC cis rs4820294 0.669 rs1894532 chr22:38059750 T/C cg21798802 chr22:38057573 PDXP 0.35 7.23 0.37 3.32e-12 Fat distribution (HIV); LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg12432903 chr7:1882776 MAD1L1 -0.37 -5.89 -0.31 9.45e-9 Bipolar disorder and schizophrenia; LUSC trans rs853679 0.546 rs200948 chr6:27835272 T/C cg06606381 chr12:133084897 FBRSL1 -0.81 -7.69 -0.39 1.71e-13 Depression; LUSC trans rs4295623 0.553 rs34962960 chr8:11594597 G/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.27 -0.32 1.15e-9 Morning vs. evening chronotype; LUSC cis rs2742234 0.541 rs2742235 chr10:43616325 A/G cg15436174 chr10:43711423 RASGEF1A -0.46 -7.51 -0.38 5.29e-13 Hirschsprung disease; LUSC cis rs9326248 0.559 rs609177 chr11:116770517 A/G cg10130564 chr11:117069849 TAGLN 0.31 5.76 0.3 1.86e-8 Blood protein levels; LUSC cis rs11650494 0.710 rs74619404 chr17:47484445 C/T cg08112188 chr17:47440006 ZNF652 1.33 9.54 0.46 3.15e-19 Prostate cancer; LUSC trans rs10802346 0.515 rs1113270 chr1:246423217 A/G cg13514129 chr1:39547527 MACF1 0.74 12.07 0.55 4.49e-28 Fractional exhaled nitric oxide (childhood); LUSC cis rs9467773 0.565 rs4343916 chr6:26522675 A/T cg05738196 chr6:26577821 NA 0.74 12.18 0.55 1.72e-28 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs1908814 0.516 rs13281077 chr8:11794814 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.7e-9 Neuroticism; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.79 0.6 1.47e-34 Alzheimer's disease; LUSC cis rs7577851 0.669 rs12464941 chr2:69628089 A/T cg10773587 chr2:69614142 GFPT1 0.56 6.3 0.33 9.29e-10 Parkinson's disease (age of onset); LUSC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg07936489 chr17:37558343 FBXL20 -0.7 -9.74 -0.47 6.83e-20 Glomerular filtration rate (creatinine); LUSC cis rs12208915 0.848 rs2174740 chr6:79536565 A/G cg05283184 chr6:79620031 NA -0.42 -5.78 -0.3 1.68e-8 Left atrial antero-posterior diameter; LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg20587970 chr11:113659929 NA -1.03 -13.81 -0.6 1.22e-34 Hip circumference adjusted for BMI; LUSC cis rs61931739 0.534 rs11052984 chr12:34045904 T/C cg06521331 chr12:34319734 NA -0.51 -8.42 -0.42 1.14e-15 Morning vs. evening chronotype; LUSC cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg23173402 chr1:227635558 NA 0.59 7.08 0.36 8.53e-12 Major depressive disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13476336 chr17:38255694 NR1D1 0.42 6.01 0.31 4.83e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs8062405 0.690 rs62034351 chr16:28565489 G/A cg07382826 chr16:28625726 SULT1A1 0.28 5.88 0.31 9.79e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs12776158 0.901 rs61086796 chr10:71216848 T/C cg12610070 chr10:71211762 TSPAN15 -0.46 -5.93 -0.31 7.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs3818285 0.544 rs9787456 chr10:111711822 A/G cg00817464 chr10:111662876 XPNPEP1 -0.63 -9.08 -0.44 9.95e-18 Superior crus of antihelix expression; LUSC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg14343924 chr8:8086146 FLJ10661 0.4 5.79 0.3 1.61e-8 Mood instability; LUSC cis rs7829975 0.660 rs10093926 chr8:8549020 A/C cg15556689 chr8:8085844 FLJ10661 -0.59 -9.13 -0.45 6.7e-18 Mood instability; LUSC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.71 -0.3 2.52e-8 Total body bone mineral density; LUSC cis rs9359856 0.564 rs76069351 chr6:90425043 C/T cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.68 -0.43 1.83e-16 Bipolar disorder; LUSC cis rs4478858 0.611 rs6425721 chr1:31714807 C/T cg00250761 chr1:31883323 NA -0.34 -8.29 -0.41 2.72e-15 Alcohol dependence; LUSC cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 18.01 0.7 3.66e-51 Chronic sinus infection; LUSC cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.0 -0.44 1.72e-17 Monocyte percentage of white cells; LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg11843238 chr5:131593191 PDLIM4 0.46 7.78 0.39 9.34e-14 Acylcarnitine levels; LUSC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg11663144 chr21:46675770 NA -0.4 -6.9 -0.35 2.58e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1728785 0.818 rs1814299 chr16:68581332 G/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs925255 0.747 rs6547851 chr2:28629367 G/C cg01273330 chr2:28605224 NA 0.41 6.69 0.34 9.19e-11 Inflammatory bowel disease;Crohn's disease; LUSC trans rs72674100 1.000 rs10016964 chr4:97989089 T/C cg09670535 chr1:18959427 PAX7 -0.62 -6.34 -0.33 7.58e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg17971929 chr21:40555470 PSMG1 -0.64 -9.73 -0.47 7.26e-20 Cognitive function; LUSC cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg13010199 chr12:38710504 ALG10B 0.65 10.24 0.49 1.35e-21 Bladder cancer; LUSC cis rs7589342 0.895 rs2033008 chr2:106502585 T/A cg14210321 chr2:106509881 NCK2 -0.6 -9.09 -0.45 9.21e-18 Addiction; LUSC cis rs1538970 1.000 rs2050884 chr1:45830824 A/G cg05343316 chr1:45956843 TESK2 0.58 8.08 0.4 1.22e-14 Platelet count; LUSC cis rs59104589 0.535 rs73004374 chr2:242378000 T/C cg14842376 chr2:242211374 HDLBP 0.5 5.8 0.3 1.57e-8 Fibrinogen levels; LUSC cis rs8099014 1.000 rs17064977 chr18:56107697 C/T cg12907477 chr18:56117327 MIR122 0.41 6.54 0.34 2.24e-10 Platelet count; LUSC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.43 -0.5 3.09e-22 Gut microbiome composition (summer); LUSC cis rs911119 1.000 rs5030707 chr20:23618656 C/G cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9287719 0.935 rs1309 chr2:10743546 A/G cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg18681998 chr4:17616180 MED28 0.85 16.13 0.66 1.06e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg11632617 chr15:75315747 PPCDC -0.52 -6.76 -0.35 6.32e-11 Blood trace element (Zn levels); LUSC trans rs9291683 0.526 rs7695555 chr4:10001656 T/C cg26043149 chr18:55253948 FECH 0.43 6.32 0.33 8.57e-10 Bone mineral density; LUSC cis rs6964587 0.967 rs34863529 chr7:91644341 C/G cg17063962 chr7:91808500 NA 0.56 8.69 0.43 1.67e-16 Breast cancer; LUSC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg18200150 chr17:30822561 MYO1D 0.52 10.91 0.51 6.73e-24 Schizophrenia; LUSC cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg16339924 chr4:17578868 LAP3 0.58 8.75 0.43 1.1e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8077889 0.871 rs72836549 chr17:41904360 G/T cg26893861 chr17:41843967 DUSP3 0.96 14.8 0.63 1.86e-38 Triglycerides; LUSC cis rs13315871 1.000 rs9844128 chr3:58391127 C/T cg12435725 chr3:58293450 RPP14 -0.73 -7.35 -0.37 1.56e-12 Cholesterol, total; LUSC cis rs72781680 0.652 rs72794281 chr2:23893265 G/A cg08917208 chr2:24149416 ATAD2B 0.98 9.69 0.47 1.02e-19 Lymphocyte counts; LUSC cis rs2228479 0.681 rs10153196 chr16:89967397 A/C cg04013166 chr16:89971882 TCF25 0.64 7.33 0.37 1.71e-12 Skin colour saturation; LUSC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg27541892 chr1:1571801 CDK11B 0.52 8.54 0.42 4.75e-16 Body mass index; LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg11062466 chr8:58055876 NA 0.72 8.79 0.43 8.28e-17 Developmental language disorder (linguistic errors); LUSC cis rs4947962 0.651 rs17586365 chr7:55140786 A/G cg23757825 chr7:55092271 EGFR 0.61 7.35 0.37 1.51e-12 Subjective response to lithium treatment; LUSC trans rs9291683 0.507 rs3796837 chr4:10011321 C/G cg26043149 chr18:55253948 FECH 0.51 7.59 0.38 3.2e-13 Bone mineral density; LUSC cis rs12618769 0.597 rs10199199 chr2:99061834 T/C cg10123293 chr2:99228465 UNC50 0.46 7.72 0.39 1.39e-13 Bipolar disorder; LUSC cis rs208520 0.837 rs208467 chr6:66914837 T/C cg07460842 chr6:66804631 NA -1.01 -14.28 -0.62 1.98e-36 Exhaled nitric oxide output; LUSC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.54 -0.34 2.34e-10 Schizophrenia; LUSC trans rs7819412 0.540 rs11777355 chr8:11044689 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.1 -0.36 7.39e-12 Triglycerides; LUSC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -10.3 -0.49 8.52e-22 Menarche (age at onset); LUSC cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg04545296 chr12:48745243 ZNF641 0.37 6.68 0.34 1.01e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9399135 0.967 rs6902438 chr6:135336587 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.07 0.44 1.01e-17 Red blood cell count; LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs10844848 chr12:34409705 A/C cg13010199 chr12:38710504 ALG10B 0.69 10.93 0.51 5.83e-24 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.62 -5.94 -0.31 7.17e-9 Cerebrospinal P-tau181p levels; LUSC cis rs1865760 1.000 rs7770139 chr6:25925823 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.79 0.35 5.03e-11 Height; LUSC cis rs7904985 1.000 rs7084928 chr10:88122516 C/T cg07322936 chr10:88137208 NA -0.58 -7.4 -0.38 1.1e-12 Barrett's esophagus; LUSC cis rs7577851 0.672 rs60680381 chr2:69533492 A/G cg10773587 chr2:69614142 GFPT1 0.59 6.38 0.33 6.04e-10 Parkinson's disease (age of onset); LUSC trans rs7465272 1.000 rs35476574 chr8:143683784 C/A cg23094728 chr5:56110263 MAP3K1 0.45 6.02 0.31 4.63e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg08882882 chr6:84937375 KIAA1009 0.45 6.02 0.31 4.59e-9 Cognitive function;Information processing speed; LUSC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg10053473 chr17:62856997 LRRC37A3 -0.68 -10.9 -0.51 7.23e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1008375 1.000 rs2872958 chr4:17665032 A/G cg04450456 chr4:17643702 FAM184B 0.41 6.84 0.35 3.75e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg05896524 chr21:47604654 C21orf56 0.47 7.07 0.36 9.19e-12 Testicular germ cell tumor; LUSC cis rs1198872 0.558 rs10929699 chr2:10918209 C/T cg15705551 chr2:10952987 PDIA6 0.48 6.29 0.33 9.93e-10 Cardiac Troponin-T levels; LUSC cis rs1580019 0.921 rs1580023 chr7:32497881 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.86 0.54 2.63e-27 Cognitive ability; LUSC cis rs8114671 0.836 rs6142294 chr20:33671497 A/G cg24642439 chr20:33292090 TP53INP2 -0.4 -5.8 -0.3 1.54e-8 Height; LUSC trans rs11039798 0.582 rs1304193 chr11:48688588 C/T cg03929089 chr4:120376271 NA 0.67 7.39 0.37 1.2e-12 Axial length; LUSC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg15839431 chr19:19639596 YJEFN3 -0.4 -5.69 -0.3 2.76e-8 Tonsillectomy; LUSC cis rs7107174 0.892 rs1893449 chr11:77968977 G/C cg02023728 chr11:77925099 USP35 0.52 7.2 0.37 4.11e-12 Testicular germ cell tumor; LUSC cis rs2235544 0.565 rs665421 chr1:54469883 T/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.01 0.31 4.76e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs440932 0.798 rs330942 chr8:9020439 A/C cg15556689 chr8:8085844 FLJ10661 0.42 6.15 0.32 2.17e-9 High light scatter reticulocyte percentage of red cells; LUSC trans rs10435719 0.902 rs11250179 chr8:11800332 C/T cg15556689 chr8:8085844 FLJ10661 0.58 8.88 0.44 4.09e-17 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg13126279 chr21:47581558 C21orf56 -0.4 -5.78 -0.3 1.75e-8 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC trans rs12210905 0.925 rs12193463 chr6:26961882 T/G cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs1577917 0.958 rs67024565 chr6:86553997 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.64 -8.87 -0.44 4.66e-17 Response to antipsychotic treatment; LUSC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg03233332 chr7:66118400 NA 0.42 6.12 0.32 2.67e-9 Aortic root size; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg09033563 chr22:24373618 LOC391322 -0.48 -6.74 -0.35 7.08e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9356171 0.572 rs2281407 chr6:164325926 C/T cg25752492 chr6:164341247 NA -0.38 -6.54 -0.34 2.25e-10 Diisocyanate-induced asthma; LUSC cis rs61931739 0.500 rs11053194 chr12:34440841 A/G cg06521331 chr12:34319734 NA -0.41 -6.74 -0.35 6.92e-11 Morning vs. evening chronotype; LUSC cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.92 -13.36 -0.59 6.46e-33 Chronic sinus infection; LUSC cis rs7940866 0.874 rs7111478 chr11:130819628 A/G cg12179176 chr11:130786555 SNX19 0.62 9.39 0.46 9.86e-19 Schizophrenia; LUSC cis rs2236918 0.710 rs851781 chr1:242034868 C/T cg17736920 chr1:242011382 EXO1 0.42 6.59 0.34 1.7e-10 Menopause (age at onset); LUSC cis rs4478858 0.735 rs1566963 chr1:31772206 G/A cg00250761 chr1:31883323 NA -0.33 -7.82 -0.39 6.82e-14 Alcohol dependence; LUSC cis rs7605827 0.930 rs7605274 chr2:15604269 A/T cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs8062405 1.000 rs7198606 chr16:28875122 T/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg03233332 chr7:66118400 NA -0.41 -5.95 -0.31 6.91e-9 Aortic root size; LUSC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7408868 0.520 rs10417567 chr19:15308068 C/T cg14696996 chr19:15285081 NOTCH3 -0.72 -7.17 -0.37 4.71e-12 Pulse pressure; LUSC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg20503657 chr10:835505 NA 0.97 13.38 0.59 5.37e-33 Eosinophil percentage of granulocytes; LUSC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg24531977 chr5:56204891 C5orf35 -1.01 -15.01 -0.63 2.75e-39 Initial pursuit acceleration; LUSC cis rs7937682 0.883 rs1789351 chr11:111456436 T/A cg19812747 chr11:111475976 SIK2 -0.55 -8.08 -0.4 1.16e-14 Primary sclerosing cholangitis; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg19747945 chr6:42946146 PEX6 -0.35 -5.88 -0.31 9.89e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs951366 0.576 rs11240559 chr1:205709621 T/G cg07157834 chr1:205819609 PM20D1 -0.44 -5.89 -0.31 9.66e-9 Menarche (age at onset); LUSC cis rs9650657 0.530 rs6982381 chr8:10952500 A/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.94 -0.31 7.29e-9 Neuroticism; LUSC cis rs1577917 0.839 rs6929514 chr6:86525768 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.35 -0.33 6.87e-10 Response to antipsychotic treatment; LUSC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg15557168 chr22:42548783 NA -0.34 -5.65 -0.3 3.39e-8 Cognitive function; LUSC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.17 0.32 2.03e-9 Height; LUSC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.77e-9 Aortic root size; LUSC cis rs11039100 1.000 rs35466594 chr11:5826684 T/G cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.66 0.34 1.15e-10 Menopause (age at onset); LUSC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg15445000 chr17:37608096 MED1 -0.38 -6.58 -0.34 1.84e-10 Glomerular filtration rate (creatinine); LUSC cis rs7091068 0.707 rs829107 chr10:95418102 C/T cg20715218 chr10:95462985 C10orf4 -0.56 -5.83 -0.3 1.33e-8 Urinary tract infection frequency; LUSC cis rs9807989 0.507 rs10204757 chr2:102998974 A/C cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.27e-12 Asthma; LUSC cis rs7917772 0.582 rs7907417 chr10:104370662 A/G cg22532475 chr10:104410764 TRIM8 0.26 6.23 0.32 1.39e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1215050 0.791 rs165242 chr4:98686482 A/C cg05340658 chr4:99064831 C4orf37 -0.37 -5.67 -0.3 3.14e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs12618769 0.597 rs2278206 chr2:99172244 A/G cg10123293 chr2:99228465 UNC50 0.46 7.27 0.37 2.57e-12 Bipolar disorder; LUSC cis rs8060686 0.623 rs6499157 chr16:68105474 A/C cg09835421 chr16:68378352 PRMT7 -0.43 -5.74 -0.3 2.16e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg16235748 chr6:149772707 ZC3H12D -0.28 -5.74 -0.3 2.09e-8 Dupuytren's disease; LUSC cis rs8060686 0.641 rs112099181 chr16:68154230 T/C cg05110241 chr16:68378359 PRMT7 -0.52 -6.21 -0.32 1.6e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs6435862 0.500 rs12477063 chr2:215673664 C/T cg04004882 chr2:215674386 BARD1 -0.55 -7.99 -0.4 2.27e-14 Neuroblastoma (high-risk); LUSC cis rs12286929 0.687 rs6589485 chr11:115083875 G/A cg04055981 chr11:115044050 NA -0.36 -6.28 -0.32 1.07e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs877282 0.898 rs2004478 chr10:770709 C/A cg13042288 chr15:90349979 ANPEP -0.46 -6.67 -0.34 1.07e-10 Uric acid levels; LUSC cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg23711669 chr6:146136114 FBXO30 0.87 16.03 0.66 2.75e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg15242686 chr22:24348715 GSTTP1 0.42 6.21 0.32 1.53e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4950928 0.887 rs7556099 chr1:203166198 C/G cg17014757 chr1:203156097 CHI3L1 -0.43 -7.66 -0.39 2.09e-13 YKL-40 levels; LUSC cis rs2486288 0.656 rs8041702 chr15:45547093 C/T cg04036182 chr15:45458818 NA -0.39 -6.35 -0.33 6.96e-10 Glomerular filtration rate; LUSC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg17252645 chr8:143867129 LY6D 0.37 6.58 0.34 1.77e-10 Urinary tract infection frequency; LUSC trans rs1728785 0.892 rs1103955 chr16:68588488 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.29 0.41 2.71e-15 Ulcerative colitis; LUSC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg22535103 chr8:58192502 C8orf71 -0.58 -6.89 -0.35 2.76e-11 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg23985595 chr17:80112537 CCDC57 0.33 6.49 0.33 3.11e-10 Life satisfaction; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg07806771 chr7:64541737 NA 0.44 6.32 0.33 8.38e-10 Calcium levels; LUSC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 11.15 0.52 9.46e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4925386 0.921 rs11204472 chr20:60920887 G/A cg06026331 chr20:60912101 LAMA5 -0.42 -5.72 -0.3 2.41e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs7715806 0.500 rs72633985 chr5:75006384 A/G cg19683494 chr5:74908142 NA 0.57 7.68 0.39 1.83e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs929354 0.772 rs6971896 chr7:156978412 C/T cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs3087591 1.000 rs8082020 chr17:29694795 G/A cg24425628 chr17:29625626 OMG;NF1 -0.58 -8.18 -0.41 6.14e-15 Hip circumference; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00513467 chr9:21335551 KLHL9 -0.38 -6.44 -0.33 4.18e-10 Electrocardiographic conduction measures; LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.07 15.97 0.66 4.76e-43 Gut microbiome composition (summer); LUSC cis rs921968 0.565 rs7605055 chr2:219627050 G/C cg02176678 chr2:219576539 TTLL4 -0.58 -10.36 -0.49 5.62e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs3126085 0.935 rs12401851 chr1:152259022 T/C cg26876637 chr1:152193138 HRNR -0.44 -5.91 -0.31 8.63e-9 Atopic dermatitis; LUSC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg19748678 chr4:122722346 EXOSC9 0.49 7.57 0.38 3.59e-13 Type 2 diabetes; LUSC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg18252515 chr7:66147081 NA -1.19 -12.97 -0.58 2.03e-31 Diabetic kidney disease; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.49 -7.37 -0.37 1.33e-12 Renal function-related traits (BUN); LUSC cis rs1403694 0.695 rs67173199 chr3:186432858 G/A cg12454167 chr3:186435060 KNG1 0.34 8.4 0.42 1.26e-15 Blood protein levels; LUSC cis rs2070488 0.745 rs9838792 chr3:38546726 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.69 -12.07 -0.55 4.42e-28 Electrocardiographic conduction measures; LUSC cis rs921968 0.541 rs634590 chr2:219372768 C/A cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs9486719 0.790 rs2499790 chr6:96845078 G/A cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs12980942 0.935 rs2241718 chr19:41829606 G/A cg25627403 chr19:41769009 HNRNPUL1 0.57 6.14 0.32 2.37e-9 Coronary artery disease; LUSC cis rs2607426 1.000 rs2604877 chr19:41275048 T/C cg05508168 chr19:41255947 C19orf54;SNRPA 0.63 5.7 0.3 2.68e-8 Blood protein levels; LUSC cis rs1949733 1.000 rs3103071 chr4:8508579 C/G cg11789530 chr4:8429930 ACOX3 -0.6 -8.78 -0.43 8.78e-17 Response to antineoplastic agents; LUSC cis rs66573146 0.634 rs56097119 chr4:7018692 C/G cg00086871 chr4:6988644 TBC1D14 0.89 8.93 0.44 2.86e-17 Granulocyte percentage of myeloid white cells; LUSC cis rs4363385 0.747 rs4240866 chr1:152954875 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.78 -0.39 9.11e-14 Inflammatory skin disease; LUSC cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.27 0.59 1.45e-32 Chronic sinus infection; LUSC cis rs66887589 0.967 rs2892869 chr4:120521297 T/C cg09307838 chr4:120376055 NA -0.48 -7.3 -0.37 2.15e-12 Diastolic blood pressure; LUSC cis rs9660992 0.508 rs113817010 chr1:205104581 C/A cg00857998 chr1:205179979 DSTYK 0.66 10.43 0.5 3.11e-22 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1577917 0.958 rs2324839 chr6:86536942 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs1729951 0.575 rs2163896 chr3:136691177 G/A cg21827317 chr3:136751795 NA 0.39 6.96 0.36 1.83e-11 Neuroticism; LUSC cis rs911119 0.955 rs67997662 chr20:23592864 G/A cg16589663 chr20:23618590 CST3 0.57 6.79 0.35 5.04e-11 Chronic kidney disease; LUSC cis rs9420 0.961 rs527528 chr11:57433327 C/T cg23127183 chr11:57508653 C11orf31 -0.51 -7.7 -0.39 1.55e-13 Schizophrenia; LUSC trans rs4332037 0.539 rs34809719 chr7:2028968 G/T cg25206134 chr2:45395956 NA 0.61 6.92 0.35 2.38e-11 Bipolar disorder; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg11062466 chr8:58055876 NA 0.76 9.09 0.45 9.22e-18 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg22166914 chr1:53195759 ZYG11B -0.49 -7.71 -0.39 1.5e-13 Monocyte count; LUSC cis rs4604732 0.631 rs11490200 chr1:247625915 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg25767906 chr1:53392781 SCP2 0.39 6.64 0.34 1.29e-10 Monocyte count; LUSC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg04414720 chr1:150670196 GOLPH3L 0.56 8.99 0.44 1.87e-17 Tonsillectomy; LUSC cis rs4499344 0.657 rs4805768 chr19:33049678 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.75 -10.04 -0.48 6.55e-21 Mean platelet volume; LUSC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg10802521 chr3:52805072 NEK4 -0.53 -8.46 -0.42 8.34e-16 Bipolar disorder; LUSC cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC cis rs2816316 0.943 rs2760524 chr1:192530548 C/T cg02586212 chr1:192544902 RGS1 -0.31 -5.68 -0.3 2.86e-8 Celiac disease; LUSC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg02018176 chr4:1364513 KIAA1530 -0.54 -9.43 -0.46 7.04e-19 Obesity-related traits; LUSC cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg23788917 chr6:8435910 SLC35B3 0.48 7.03 0.36 1.17e-11 Motion sickness; LUSC cis rs7824557 0.628 rs7841394 chr8:11185671 G/T cg21293242 chr8:11204541 TDH 0.32 6.0 0.31 5.24e-9 Retinal vascular caliber; LUSC cis rs7296418 0.961 rs11608811 chr12:123529056 A/G cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.43 -0.42 1.04e-15 Platelet count; LUSC cis rs7106204 0.748 rs4382909 chr11:24236618 C/T ch.11.24196551F chr11:24239977 NA 1.16 14.62 0.62 8.9e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs8028182 0.501 rs11072553 chr15:75932777 C/T cg20655648 chr15:75932815 IMP3 0.46 6.03 0.31 4.31e-9 Sudden cardiac arrest; LUSC cis rs1577917 0.917 rs1414201 chr6:86500316 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.82 -0.43 6.53e-17 Response to antipsychotic treatment; LUSC cis rs12973672 1.000 rs1051995 chr19:35770292 C/T cg12095397 chr19:35769544 USF2 0.44 6.91 0.35 2.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.29e-12 Extrinsic epigenetic age acceleration; LUSC cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg27279351 chr12:120934652 DYNLL1 0.63 8.35 0.42 1.8e-15 High light scatter reticulocyte count; LUSC cis rs1008375 0.898 rs4698623 chr4:17594702 T/C cg16339924 chr4:17578868 LAP3 0.63 9.83 0.47 3.27e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs11098499 0.775 rs2002049 chr4:120257417 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.34e-10 Corneal astigmatism; LUSC cis rs9467711 0.606 rs12173854 chr6:26371679 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1996152 0.543 rs9906415 chr17:72389282 A/G cg23221732 chr17:72383708 NA 0.32 6.34 0.33 7.41e-10 Interleukin-12p70 levels; LUSC cis rs12681287 0.640 rs7816629 chr8:87350788 A/T cg27223183 chr8:87520930 FAM82B -0.54 -7.06 -0.36 9.96e-12 Caudate activity during reward; LUSC trans rs7937682 0.575 rs7950926 chr11:111776437 G/C cg18187862 chr3:45730750 SACM1L -0.53 -6.66 -0.34 1.14e-10 Primary sclerosing cholangitis; LUSC cis rs1801251 0.963 rs66549961 chr2:233602293 A/G cg08000102 chr2:233561755 GIGYF2 0.68 11.22 0.52 5.36e-25 Coronary artery disease; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg26304593 chr6:42947056 PEX6 -0.52 -8.27 -0.41 3.21e-15 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs11098499 0.866 rs7677068 chr4:120291704 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.53 0.38 4.82e-13 Corneal astigmatism; LUSC cis rs9747201 0.962 rs35051180 chr17:80135046 G/A cg17462356 chr17:80056334 FASN 0.46 6.21 0.32 1.53e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg21427119 chr20:30132790 HM13 -0.38 -5.82 -0.3 1.37e-8 Mean corpuscular hemoglobin; LUSC cis rs2046867 0.628 rs62249880 chr3:72918940 C/T cg25664220 chr3:72788482 NA -0.58 -10.29 -0.49 9.51e-22 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs1912483 0.505 rs11079772 chr17:45393739 A/C cg03185820 chr7:149158252 ZNF777 0.37 6.1 0.32 3.01e-9 Coronary artery disease; LUSC cis rs6500395 0.775 rs13331298 chr16:48661489 G/A cg04672837 chr16:48644449 N4BP1 0.46 6.97 0.36 1.7e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg09177884 chr7:1199841 ZFAND2A -0.53 -7.11 -0.36 6.97e-12 Longevity;Endometriosis; LUSC cis rs3845702 1.000 rs3845697 chr2:180798553 C/T cg01881094 chr2:180872142 CWC22 0.81 10.23 0.49 1.49e-21 Schizophrenia; LUSC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg13498757 chr1:152161927 NA 0.35 5.77 0.3 1.78e-8 Inflammatory skin disease; LUSC cis rs9660992 0.674 rs17345816 chr1:205262868 A/T cg21643547 chr1:205240462 TMCC2 0.5 9.5 0.46 4.26e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7107174 1.000 rs2450128 chr11:77940075 G/A cg02023728 chr11:77925099 USP35 0.54 7.76 0.39 1.08e-13 Testicular germ cell tumor; LUSC cis rs61990749 0.597 rs2364584 chr14:78152286 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.38 -0.33 6.06e-10 Fibroblast growth factor basic levels; LUSC cis rs7020830 0.861 rs13289001 chr9:37311592 A/G cg14294708 chr9:37120828 ZCCHC7 1.1 26.23 0.82 4.23e-83 Schizophrenia; LUSC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg19318889 chr4:1322082 MAEA 0.56 9.52 0.46 3.67e-19 Longevity; LUSC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.11 -0.32 2.77e-9 Major depressive disorder; LUSC cis rs73129298 0.551 rs4647958 chr20:48600631 T/C cg25655593 chr20:48599521 SNAI1 0.6 6.43 0.33 4.49e-10 Inflammatory skin disease; LUSC cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.13 -0.36 6.41e-12 Menopause (age at onset); LUSC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.74 -9.39 -0.46 9.84e-19 Gut microbiome composition (summer); LUSC cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg21466736 chr12:48725269 NA -0.33 -5.73 -0.3 2.2e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg04141948 chr7:1023156 CYP2W1 0.28 5.87 0.31 1.03e-8 Longevity;Endometriosis; LUSC cis rs2115536 0.640 rs934134 chr15:80168218 T/C cg00225070 chr15:80189496 MTHFS 0.43 6.12 0.32 2.55e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7584330 0.826 rs72620825 chr2:238381243 G/A cg14458575 chr2:238380390 NA 0.85 14.2 0.61 4.06e-36 Prostate cancer; LUSC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg09650180 chr20:62225654 GMEB2 -0.67 -9.6 -0.47 1.9e-19 Glioblastoma; LUSC cis rs66887589 0.616 rs1052633 chr4:120215314 A/G cg24375607 chr4:120327624 NA 0.5 7.46 0.38 7.65e-13 Diastolic blood pressure; LUSC cis rs7923609 0.967 rs7915779 chr10:65244244 G/C cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.1e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs4268898 0.636 rs76172309 chr2:24458911 G/C cg06627628 chr2:24431161 ITSN2 -0.87 -12.73 -0.57 1.52e-30 Asthma; LUSC cis rs9811920 0.809 rs13059754 chr3:99678490 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.41 -7.79 -0.39 8.44e-14 Axial length; LUSC cis rs9660992 0.674 rs12122105 chr1:205256818 C/T cg21545522 chr1:205238299 TMCC2 0.5 9.4 0.46 8.73e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.22 0.88 3.18e-111 Chronic sinus infection; LUSC trans rs7951105 1.000 rs1906684 chr11:39254930 G/A cg24085930 chr3:21832523 NA 0.48 6.02 0.31 4.72e-9 Free thyroxine concentration; LUSC cis rs6964587 0.900 rs6465352 chr7:91775117 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.89 0.31 9.34e-9 Breast cancer; LUSC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg04362960 chr10:104952993 NT5C2 0.58 9.07 0.44 1.03e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg03351412 chr1:154909251 PMVK 0.51 7.84 0.39 6.3e-14 Prostate cancer; LUSC trans rs3733585 0.699 rs7435196 chr4:9967556 A/C cg26043149 chr18:55253948 FECH -0.46 -6.98 -0.36 1.55e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs853679 0.607 rs13208096 chr6:28225311 C/G cg06606381 chr12:133084897 FBRSL1 -1.04 -9.45 -0.46 6.23e-19 Depression; LUSC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.65 -0.34 1.21e-10 Total body bone mineral density; LUSC cis rs10193935 0.901 rs59890734 chr2:42595662 G/A cg27598129 chr2:42591480 NA -0.66 -8.78 -0.43 8.72e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7824557 0.564 rs2043508 chr8:11227406 G/A cg27411982 chr8:10470053 RP1L1 -0.39 -6.05 -0.31 3.78e-9 Retinal vascular caliber; LUSC cis rs7809950 0.906 rs62483723 chr7:107186358 A/C cg23024343 chr7:107201750 COG5 -0.55 -8.7 -0.43 1.53e-16 Coronary artery disease; LUSC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg21770322 chr7:97807741 LMTK2 0.42 7.51 0.38 5.55e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.34e-8 Diabetic kidney disease; LUSC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg02038168 chr22:39784481 NA -0.49 -7.85 -0.39 5.62e-14 Intelligence (multi-trait analysis); LUSC cis rs7577696 0.554 rs35978916 chr2:32400635 T/C cg02381751 chr2:32503542 YIPF4 -0.56 -7.26 -0.37 2.68e-12 Inflammatory biomarkers; LUSC cis rs1729951 0.575 rs16844325 chr3:136678161 C/G cg21827317 chr3:136751795 NA 0.39 6.91 0.35 2.41e-11 Neuroticism; LUSC cis rs73198271 0.740 rs10098636 chr8:8647324 C/T cg15556689 chr8:8085844 FLJ10661 -0.47 -6.2 -0.32 1.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs757081 0.667 rs60173525 chr11:17259967 A/G cg15432903 chr11:17409602 KCNJ11 -0.38 -5.9 -0.31 8.75e-9 Systolic blood pressure; LUSC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg22823121 chr1:150693482 HORMAD1 -0.45 -6.73 -0.35 7.45e-11 Tonsillectomy; LUSC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg11663144 chr21:46675770 NA -0.4 -7.11 -0.36 6.96e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2219968 1.000 rs6473087 chr8:78974859 A/G cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9300255 0.739 rs6633 chr12:123745809 G/T cg00376283 chr12:123451042 ABCB9 -0.7 -7.81 -0.39 7.42e-14 Neutrophil percentage of white cells; LUSC cis rs7106204 0.614 rs117122818 chr11:24245880 C/T ch.11.24196551F chr11:24239977 NA 1.01 9.09 0.45 9.05e-18 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.54 -8.07 -0.4 1.29e-14 Axial length; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg11494091 chr17:61959527 GH2 0.61 13.02 0.58 1.31e-31 Prudent dietary pattern; LUSC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7809950 1.000 rs2808 chr7:107260856 A/G cg23024343 chr7:107201750 COG5 0.54 8.41 0.42 1.2e-15 Coronary artery disease; LUSC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.86 10.86 0.51 1.01e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs422249 0.547 rs174537 chr11:61552680 G/T cg19610905 chr11:61596333 FADS2 -0.54 -8.2 -0.41 5.22e-15 Trans fatty acid levels; LUSC cis rs9650657 0.538 rs11250093 chr8:10798828 C/T cg27411982 chr8:10470053 RP1L1 0.46 6.83 0.35 4.01e-11 Neuroticism; LUSC cis rs11864453 0.749 rs7192730 chr16:72124219 T/C cg01557791 chr16:72042693 DHODH -0.52 -7.54 -0.38 4.42e-13 Fibrinogen levels; LUSC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg12310025 chr6:25882481 NA -0.5 -8.34 -0.42 1.97e-15 Intelligence (multi-trait analysis); LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G ch.19.748535F chr19:17764577 UNC13A 0.38 6.07 0.32 3.48e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg20019365 chr2:219134978 PNKD;AAMP -0.47 -7.16 -0.36 5.16e-12 Colorectal cancer; LUSC cis rs2797160 1.000 rs1739367 chr6:126004720 G/T cg05901451 chr6:126070800 HEY2 -0.58 -8.59 -0.43 3.43e-16 Endometrial cancer; LUSC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg01652190 chr22:50026171 C22orf34 -0.3 -6.16 -0.32 2.04e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs56399783 0.901 rs17300022 chr7:2808517 C/T cg19731401 chr7:2775893 GNA12 -0.66 -8.52 -0.42 5.64e-16 Childhood ear infection; LUSC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg13175981 chr1:150552382 MCL1 0.44 5.74 0.3 2.1e-8 Blood protein levels; LUSC cis rs11785400 0.793 rs4403386 chr8:143736770 C/G cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg02487422 chr3:49467188 NICN1 0.44 7.01 0.36 1.33e-11 Resting heart rate; LUSC cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg10172584 chr19:19639581 YJEFN3 -0.48 -5.71 -0.3 2.5e-8 Bipolar disorder; LUSC trans rs7939886 0.841 rs11227702 chr11:56034774 A/C cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg24324837 chr19:49891574 CCDC155 0.52 7.4 0.38 1.1e-12 Multiple sclerosis; LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16732880 chr16:791244 NARFL -0.45 -6.58 -0.34 1.79e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs308403 0.568 rs67050821 chr4:123674383 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.79 9.88 0.48 2.3e-20 Blood protein levels; LUSC cis rs10992471 0.597 rs11789163 chr9:95234973 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.58 -0.34 1.78e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg02018176 chr4:1364513 KIAA1530 -0.43 -7.56 -0.38 4.04e-13 Obesity-related traits; LUSC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.45 6.37 0.33 6.4e-10 Tonsillectomy; LUSC cis rs7789940 0.951 rs73140055 chr7:75975777 A/T cg15798862 chr7:76129360 DTX2 -0.48 -7.93 -0.4 3.23e-14 Multiple sclerosis; LUSC cis rs4930561 0.714 rs6591335 chr11:67976812 T/C cg04465784 chr11:67976953 SUV420H1 -0.29 -5.71 -0.3 2.43e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs11105298 0.891 rs11105316 chr12:89925200 T/G cg00757033 chr12:89920650 WDR51B 0.59 10.4 0.49 3.99e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 3.03e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9326248 0.559 rs12808524 chr11:116890993 T/C cg20608306 chr11:116969690 SIK3 0.38 7.04 0.36 1.09e-11 Blood protein levels; LUSC cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg24812749 chr6:127587940 RNF146 -0.81 -11.04 -0.52 2.2e-24 Breast cancer; LUSC cis rs17828380 1.000 rs71393137 chr15:63505505 G/T cg05507819 chr15:63340323 TPM1 -0.7 -5.9 -0.31 8.94e-9 Social communication problems; LUSC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs34779708 0.658 rs4934715 chr10:35364992 G/T cg04310649 chr10:35416472 CREM -0.44 -6.83 -0.35 3.97e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12579753 0.956 rs34747993 chr12:82217777 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.04 -0.31 4.21e-9 Resting heart rate; LUSC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg11812906 chr14:75593930 NEK9 -0.64 -10.99 -0.52 3.49e-24 Height; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18404041 chr3:52824283 ITIH1 -0.54 -10.29 -0.49 9.04e-22 Electroencephalogram traits; LUSC cis rs12999616 0.817 rs62157581 chr2:98327502 G/T cg26665480 chr2:98280029 ACTR1B 0.53 6.05 0.31 3.91e-9 Colorectal cancer; LUSC cis rs7618501 1.000 rs6802890 chr3:49832261 A/G cg13072238 chr3:49761600 GMPPB 0.41 6.86 0.35 3.33e-11 Intelligence (multi-trait analysis); LUSC cis rs1124376 0.935 rs12490215 chr3:20156185 A/G cg05072819 chr3:20081367 KAT2B 0.6 7.1 0.36 7.58e-12 Bipolar disorder and schizophrenia; LUSC cis rs7568458 0.709 rs56819945 chr2:85755139 C/T cg23752985 chr2:85803571 VAMP8 0.33 6.44 0.33 4.16e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1215050 0.791 rs783950 chr4:98878395 C/T cg05340658 chr4:99064831 C4orf37 -0.44 -6.85 -0.35 3.49e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs240764 0.658 rs10457077 chr6:101196767 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC cis rs9549367 0.789 rs9549699 chr13:113878263 T/A cg18105134 chr13:113819100 PROZ -0.69 -9.94 -0.48 1.48e-20 Platelet distribution width; LUSC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7914558 1.000 rs11191577 chr10:104902165 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.58 0.46 2.38e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg06191203 chr2:152266755 RIF1 -0.54 -7.33 -0.37 1.71e-12 Lung cancer; LUSC cis rs6456156 0.586 rs12528689 chr6:167461746 A/G cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs6121246 0.567 rs6058197 chr20:30194899 A/G cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs7818345 0.967 rs12543061 chr8:19286181 G/T cg11303988 chr8:19266685 CSGALNACT1 -0.38 -7.47 -0.38 6.86e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs4919687 0.577 rs12765459 chr10:104465687 G/C cg05855489 chr10:104503620 C10orf26 0.75 11.25 0.52 3.97e-25 Colorectal cancer; LUSC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg18827107 chr12:86230957 RASSF9 -0.49 -7.15 -0.36 5.47e-12 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17484629 chr4:111119220 ELOVL6 -0.45 -6.62 -0.34 1.41e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs477692 1.000 rs522891 chr10:131430916 T/C cg11019008 chr10:131425282 MGMT -0.4 -5.95 -0.31 6.82e-9 Response to temozolomide; LUSC cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg06784218 chr1:46089804 CCDC17 0.36 6.12 0.32 2.66e-9 Platelet count; LUSC cis rs11785400 0.793 rs9297970 chr8:143723386 C/T cg10596483 chr8:143751796 JRK 0.52 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.79 0.39 8.73e-14 Prudent dietary pattern; LUSC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg11764359 chr7:65958608 NA -0.7 -10.81 -0.51 1.42e-23 Aortic root size; LUSC cis rs250677 0.652 rs1422582 chr5:148436925 T/C cg12140854 chr5:148520817 ABLIM3 -0.4 -5.94 -0.31 7.27e-9 Breast cancer; LUSC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg21970626 chr13:21893289 NA -0.42 -5.67 -0.3 3.12e-8 White matter hyperintensity burden; LUSC cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg15352829 chr14:105391018 PLD4 -0.41 -8.51 -0.42 5.91e-16 Rheumatoid arthritis; LUSC cis rs5758659 0.652 rs133314 chr22:42401841 G/A cg15557168 chr22:42548783 NA -0.33 -5.72 -0.3 2.43e-8 Cognitive function; LUSC cis rs6740322 0.696 rs10188539 chr2:43484675 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -6.46 -0.33 3.65e-10 Coronary artery disease; LUSC cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg06454157 chr6:167490870 NA -0.24 -6.04 -0.31 4.19e-9 Crohn's disease; LUSC trans rs10506458 0.915 rs17763441 chr12:63418335 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.58 -0.65 1.68e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg07636037 chr3:49044803 WDR6 0.91 13.97 0.61 2.92e-35 Menarche (age at onset); LUSC cis rs12950390 0.893 rs11079789 chr17:45849715 A/G cg06532163 chr17:45867833 NA 0.33 6.06 0.31 3.6e-9 IgG glycosylation; LUSC cis rs4629180 0.544 rs7595274 chr2:102140086 T/C cg01388757 chr2:102091195 RFX8 -0.36 -6.16 -0.32 2.03e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.92 0.31 8.17e-9 Tonsillectomy; LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.72 -0.43 1.32e-16 Bipolar disorder; LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg22920501 chr2:26401640 FAM59B 0.83 12.38 0.56 3.16e-29 Gut microbiome composition (summer); LUSC cis rs7188861 0.768 rs60409583 chr16:11392098 C/T cg00044050 chr16:11439710 C16orf75 0.57 6.35 0.33 7.17e-10 HDL cholesterol; LUSC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg12463550 chr7:65579703 CRCP -0.57 -8.62 -0.43 2.65e-16 Aortic root size; LUSC cis rs7089973 0.646 rs35453961 chr10:116638166 T/C cg25233709 chr10:116636983 FAM160B1 0.39 6.59 0.34 1.7e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.5 7.9 0.4 4.19e-14 Parkinson's disease; LUSC cis rs262150 0.530 rs2730232 chr7:158784469 C/T cg12590608 chr7:158785262 NA -0.37 -6.3 -0.33 9.26e-10 Facial morphology (factor 20); LUSC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg12463550 chr7:65579703 CRCP 0.55 8.21 0.41 4.85e-15 Aortic root size; LUSC cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg12935359 chr14:103987150 CKB -0.52 -8.09 -0.4 1.15e-14 Body mass index; LUSC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg23711669 chr6:146136114 FBXO30 0.82 14.38 0.62 8.11e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.744 rs11204737 chr1:150847647 C/T cg13175981 chr1:150552382 MCL1 0.44 6.13 0.32 2.47e-9 Tonsillectomy; LUSC cis rs500891 0.574 rs13196407 chr6:84120820 G/A cg08257003 chr6:84140564 ME1 0.34 7.6 0.38 3.06e-13 Platelet-derived growth factor BB levels; LUSC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg24531977 chr5:56204891 C5orf35 -0.95 -14.71 -0.63 4.02e-38 Initial pursuit acceleration; LUSC trans rs11098499 0.820 rs28578366 chr4:120536905 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.44 -6.28 -0.32 1.08e-9 Corneal astigmatism; LUSC cis rs61931739 0.534 rs11052973 chr12:34029708 A/G cg06521331 chr12:34319734 NA -0.47 -7.68 -0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs1670533 1.000 rs62879260 chr4:1050850 T/C cg27284194 chr4:1044797 NA 0.57 8.39 0.42 1.35e-15 Recombination rate (females); LUSC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg09640425 chr7:158790006 NA -0.4 -6.22 -0.32 1.5e-9 Facial morphology (factor 20); LUSC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.46 0.59 2.79e-33 Platelet count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11559952 chr10:112064744 SMNDC1 -0.52 -6.29 -0.33 1.01e-9 Bipolar disorder and schizophrenia; LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg24060327 chr5:131705240 SLC22A5 -0.67 -11.47 -0.53 6.44e-26 Acylcarnitine levels; LUSC cis rs12200560 0.505 rs4839849 chr6:97076673 T/C cg06623918 chr6:96969491 KIAA0776 0.5 7.21 0.37 3.75e-12 Coronary heart disease; LUSC cis rs1538970 0.924 rs12046816 chr1:45891543 G/T cg05343316 chr1:45956843 TESK2 0.65 8.88 0.44 4.17e-17 Platelet count; LUSC cis rs12928939 0.769 rs12445161 chr16:71741928 C/T cg03805757 chr16:71968109 PKD1L3 -0.4 -5.86 -0.31 1.08e-8 Post bronchodilator FEV1; LUSC cis rs9814567 0.752 rs13075117 chr3:134329535 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.78 12.62 0.57 3.86e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs477692 0.905 rs693402 chr10:131422882 G/A cg05714579 chr10:131428358 MGMT 0.52 7.98 0.4 2.44e-14 Response to temozolomide; LUSC cis rs7000551 0.725 rs2449349 chr8:22383284 A/G cg12081754 chr8:22256438 SLC39A14 0.43 6.47 0.33 3.5e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.38 0.49 4.76e-22 Schizophrenia; LUSC cis rs12367572 0.965 rs10748405 chr12:45321341 C/G cg04608330 chr12:45269318 NELL2 -0.56 -8.95 -0.44 2.49e-17 Gut microbiome composition (summer); LUSC trans rs10506458 0.915 rs1463821 chr12:63402875 C/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.26 15.61 0.65 1.19e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -7.97 -0.4 2.62e-14 Developmental language disorder (linguistic errors); LUSC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg25554036 chr4:6271136 WFS1 0.62 12.65 0.57 3.08e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2732480 0.500 rs2932093 chr12:48648271 G/T cg04545296 chr12:48745243 ZNF641 0.34 6.17 0.32 1.98e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1538970 0.816 rs61788356 chr1:46006675 C/T cg06784218 chr1:46089804 CCDC17 0.35 6.0 0.31 5.17e-9 Platelet count; LUSC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg11941060 chr3:133502564 NA -0.56 -8.62 -0.43 2.63e-16 Iron status biomarkers; LUSC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg09491104 chr22:46646882 C22orf40 0.58 7.18 0.37 4.48e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs11030122 0.702 rs10767713 chr11:3950157 T/C cg18678763 chr11:4115507 RRM1 -0.43 -5.67 -0.3 3.11e-8 Mean platelet volume;Platelet distribution width; LUSC trans rs1997103 1.000 rs6976824 chr7:55396115 A/C cg20935933 chr6:143382018 AIG1 0.43 6.55 0.34 2.15e-10 QRS interval (sulfonylurea treatment interaction); LUSC cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg08085267 chr17:45401833 C17orf57 0.54 8.83 0.44 6.01e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs9329221 0.710 rs11785061 chr8:10259528 G/C cg15556689 chr8:8085844 FLJ10661 0.57 7.82 0.39 6.97e-14 Neuroticism; LUSC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Body mass index; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg20821713 chr7:1055600 C7orf50 -0.38 -6.03 -0.31 4.42e-9 Longevity;Endometriosis; LUSC cis rs738322 0.555 rs5750548 chr22:38547016 C/A cg25457927 chr22:38595422 NA -0.4 -7.95 -0.4 2.85e-14 Cutaneous nevi; LUSC trans rs79976124 0.837 rs12194087 chr6:66644399 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 8.73 0.43 1.23e-16 Type 2 diabetes; LUSC cis rs1348850 0.632 rs11678875 chr2:178509068 A/G cg22681709 chr2:178499509 PDE11A -0.61 -12.34 -0.56 4.35e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs983392 0.805 rs7116190 chr11:59964992 G/A cg24026212 chr11:59952134 MS4A6A -0.36 -6.17 -0.32 1.95e-9 Alzheimer's disease (late onset); LUSC cis rs7267979 1.000 rs6050629 chr20:25430680 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg14440974 chr22:39074834 NA -0.35 -5.79 -0.3 1.59e-8 Menopause (age at onset); LUSC cis rs10197940 0.578 rs6718372 chr2:152345871 C/G cg06191203 chr2:152266755 RIF1 -0.42 -5.84 -0.3 1.23e-8 Lung cancer; LUSC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs1018836 0.923 rs6988733 chr8:91535686 C/T cg16814680 chr8:91681699 NA -0.76 -12.65 -0.57 3.18e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9311676 0.656 rs11130635 chr3:58379143 A/G cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs9467711 0.720 rs7749823 chr6:26158079 A/C cg12315302 chr6:26189340 HIST1H4D 0.58 5.79 0.3 1.64e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2219968 0.962 rs4565449 chr8:78939877 C/T cg00738934 chr8:78996279 NA -0.39 -6.87 -0.35 3.21e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs10761482 0.769 rs1417380 chr10:62111286 T/C cg18175470 chr10:62150864 ANK3 -0.53 -7.5 -0.38 5.65e-13 Schizophrenia; LUSC cis rs9420 0.961 rs682503 chr11:57640994 C/G cg23127183 chr11:57508653 C11orf31 0.53 7.68 0.39 1.76e-13 Schizophrenia; LUSC cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg03433033 chr1:76189801 ACADM -0.45 -6.73 -0.35 7.44e-11 Daytime sleep phenotypes; LUSC cis rs9309473 0.660 rs17349321 chr2:73643753 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -5.86 -0.31 1.14e-8 Metabolite levels; LUSC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg18876405 chr7:65276391 NA 0.6 9.58 0.46 2.35e-19 Aortic root size; LUSC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg19592336 chr6:28129416 ZNF389 0.46 6.38 0.33 5.9e-10 Parkinson's disease; LUSC trans rs2490361 0.966 rs2490362 chr1:237325861 C/T cg15653282 chr18:11689218 GNAL 0.4 6.05 0.31 3.92e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9303401 0.703 rs8077052 chr17:57208921 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.51 7.53 0.38 4.68e-13 Cognitive test performance; LUSC cis rs7605827 0.930 rs11689686 chr2:15527659 C/T cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs1113500 0.933 rs2077259 chr1:108629551 T/C cg11967332 chr1:108735228 SLC25A24 0.38 5.76 0.3 1.92e-8 Growth-regulated protein alpha levels; LUSC cis rs11758351 1.000 rs74363821 chr6:26189524 G/C cg01420254 chr6:26195488 NA 0.69 7.48 0.38 6.55e-13 Gout;Renal underexcretion gout; LUSC cis rs4077515 0.504 rs10870164 chr9:139315682 C/T cg14019695 chr9:139328340 INPP5E -0.51 -10.03 -0.48 7.34e-21 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14558428 chr5:142784982 NR3C1 -0.4 -6.05 -0.31 3.97e-9 Electrocardiographic conduction measures; LUSC cis rs9467773 0.620 rs2504599 chr6:26641060 C/T cg11502198 chr6:26597334 ABT1 0.72 12.07 0.55 4.23e-28 Intelligence (multi-trait analysis); LUSC cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg13736514 chr6:26305472 NA -0.45 -8.94 -0.44 2.72e-17 Educational attainment; LUSC trans rs7647973 0.710 rs1491983 chr3:49639803 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.63 -0.39 2.43e-13 Menarche (age at onset); LUSC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.6 -0.34 1.58e-10 Lung cancer; LUSC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg09835421 chr16:68378352 PRMT7 -0.54 -6.08 -0.32 3.32e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9650315 0.866 rs4576404 chr8:57181155 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.8 0.35 4.85e-11 Height; LUSC trans rs3733585 0.605 rs4235354 chr4:10122942 C/A cg26043149 chr18:55253948 FECH -0.52 -7.6 -0.38 3e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg15839431 chr19:19639596 YJEFN3 -0.63 -7.11 -0.36 7.15e-12 Bipolar disorder; LUSC cis rs4073582 0.595 rs474005 chr11:66033301 C/T cg16950941 chr11:66035639 RAB1B 0.53 7.8 0.39 7.78e-14 Gout; LUSC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg21573476 chr21:45109991 RRP1B -0.43 -6.97 -0.36 1.75e-11 Mean corpuscular volume; LUSC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg21361702 chr7:150065534 REPIN1 0.5 6.77 0.35 5.8200000000000003e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs11690935 0.655 rs1028127 chr2:172530036 T/C cg13550731 chr2:172543902 DYNC1I2 0.59 9.42 0.46 7.79e-19 Schizophrenia; LUSC cis rs1018836 0.923 rs13277387 chr8:91633713 C/G cg16814680 chr8:91681699 NA -0.76 -12.28 -0.56 7.07e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg02569458 chr12:86230093 RASSF9 0.48 7.63 0.39 2.4e-13 Major depressive disorder; LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg22963979 chr7:1858916 MAD1L1 -0.58 -9.02 -0.44 1.49e-17 Bipolar disorder and schizophrenia; LUSC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg07424592 chr7:64974309 NA 0.7 6.05 0.31 3.99e-9 Diabetic kidney disease; LUSC cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg17173187 chr15:85201210 NMB 0.48 9.28 0.45 2.17e-18 Schizophrenia; LUSC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg00339695 chr16:24857497 SLC5A11 0.62 9.33 0.45 1.54e-18 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.582 rs7091252 chr10:104328859 G/T cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9467711 0.606 rs34781270 chr6:26593037 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -5.79 -0.3 1.63e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs8044995 0.563 rs3785113 chr16:68369213 T/C cg05110241 chr16:68378359 PRMT7 -0.76 -8.6 -0.43 3.22e-16 Schizophrenia; LUSC cis rs780094 0.500 rs12987055 chr2:27834152 T/C cg27432699 chr2:27873401 GPN1 0.41 5.82 0.3 1.35e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC trans rs7916697 0.626 rs3858146 chr10:70013250 C/T cg04882175 chr6:131122610 NA -0.51 -6.59 -0.34 1.74e-10 Optic disc area; LUSC cis rs778371 0.723 rs6704763 chr2:233592487 C/T cg08000102 chr2:233561755 GIGYF2 0.8 13.77 0.6 1.83e-34 Schizophrenia; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg12439834 chr1:1410849 ATAD3B -0.39 -6.06 -0.31 3.75e-9 Schizophrenia (age at onset); LUSC cis rs193541 0.530 rs9327272 chr5:122073548 T/C cg19077854 chr5:122220652 SNX24 0.34 7.04 0.36 1.13e-11 Glucose homeostasis traits; LUSC cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -8.59 -0.43 3.28e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7089973 0.604 rs11196924 chr10:116571796 A/C cg03647239 chr10:116582469 FAM160B1 -0.43 -6.84 -0.35 3.71e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3862435 0.706 rs2601198 chr15:90945443 C/G cg22089800 chr15:90895588 ZNF774 -0.56 -6.12 -0.32 2.57e-9 Response to exercise (triglyceride level interaction); LUSC cis rs2276314 1.000 rs16967317 chr18:33573400 A/G cg05985134 chr18:33552581 C18orf21 0.52 7.09 0.36 8.19e-12 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs7819412 0.669 rs6601568 chr8:11073402 G/A cg15556689 chr8:8085844 FLJ10661 -0.59 -8.57 -0.42 4.02e-16 Triglycerides; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 10.05 0.48 6.22e-21 Lymphocyte counts; LUSC cis rs921968 0.565 rs2272191 chr2:219609776 G/A cg02176678 chr2:219576539 TTLL4 -0.58 -10.17 -0.49 2.38e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs2361710 0.611 rs12051781 chr17:78074468 A/G cg09238746 chr17:78121135 EIF4A3 -0.43 -6.11 -0.32 2.83e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC cis rs3790645 1.000 rs188158 chr1:26898142 A/G cg17456097 chr1:26900765 RPS6KA1 0.45 6.6 0.34 1.58e-10 Glucose homeostasis traits; LUSC cis rs11958404 0.932 rs113264420 chr5:157437779 T/C cg05962755 chr5:157440814 NA 0.53 6.3 0.33 9.34e-10 IgG glycosylation; LUSC cis rs7191700 0.578 rs243327 chr16:11353304 C/T cg00044050 chr16:11439710 C16orf75 -0.67 -12.16 -0.55 2.04e-28 Multiple sclerosis; LUSC cis rs2692947 0.666 rs10183151 chr2:96774786 T/G cg23100626 chr2:96804247 ASTL -0.29 -6.74 -0.35 6.92e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6429082 0.714 rs704719 chr1:235667170 G/A cg26050004 chr1:235667680 B3GALNT2 0.63 8.41 0.42 1.25e-15 Adiposity; LUSC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC cis rs9916302 0.706 rs57933226 chr17:37412829 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -10.2 -0.49 1.94e-21 Glomerular filtration rate (creatinine); LUSC cis rs6696846 0.791 rs7520752 chr1:205054114 C/T cg21545522 chr1:205238299 TMCC2 -0.46 -8.49 -0.42 6.98e-16 Red blood cell count; LUSC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg23093090 chr10:104574429 C10orf26 0.48 9.08 0.44 9.75e-18 Waist circumference;Hip circumference; LUSC cis rs9814567 1.000 rs55913793 chr3:134285968 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.05 -0.61 1.51e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg05872129 chr22:39784769 NA -0.59 -11.12 -0.52 1.21e-24 Intelligence (multi-trait analysis); LUSC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg06238570 chr21:40685208 BRWD1 -0.54 -8.4 -0.42 1.28e-15 Menarche (age at onset); LUSC cis rs9650315 0.866 rs34931142 chr8:57186807 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs654950 0.934 rs662999 chr1:42001160 A/C cg06885757 chr1:42089581 HIVEP3 0.41 7.69 0.39 1.65e-13 Airway imaging phenotypes; LUSC trans rs75804782 0.520 rs34058921 chr2:239318665 C/T cg01134436 chr17:81009848 B3GNTL1 0.64 6.08 0.32 3.37e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg05872129 chr22:39784769 NA -0.59 -10.95 -0.51 4.72e-24 Intelligence (multi-trait analysis); LUSC cis rs35146811 0.735 rs1727133 chr7:99812870 C/T cg13334819 chr7:99746414 C7orf59 0.5 6.79 0.35 5.04e-11 Coronary artery disease; LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.53 -7.42 -0.38 9.89e-13 Renal function-related traits (BUN); LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg08948841 chr4:1244042 CTBP1;C4orf42 0.32 6.25 0.32 1.23e-9 Obesity-related traits; LUSC cis rs10465746 0.846 rs12146038 chr1:84405065 A/T cg10977910 chr1:84465055 TTLL7 0.41 6.09 0.32 3.06e-9 Obesity-related traits; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25880573 chr1:24073129 TCEB3 -0.37 -5.99 -0.31 5.56e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9788682 0.747 rs2938671 chr15:78732754 A/G cg18825076 chr15:78729989 IREB2 -0.47 -6.49 -0.33 3.1e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs500891 0.574 rs7750443 chr6:84112468 A/G cg08257003 chr6:84140564 ME1 0.34 8.01 0.4 1.98e-14 Platelet-derived growth factor BB levels; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg08736216 chr1:53307985 ZYG11A -0.29 -6.27 -0.32 1.11e-9 Monocyte count; LUSC cis rs6977660 1.000 rs5017191 chr7:19820158 C/A cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg11764359 chr7:65958608 NA -0.58 -8.99 -0.44 1.87e-17 Aortic root size; LUSC cis rs13401104 0.754 rs11687335 chr2:237117233 A/C cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs2073300 0.609 rs77908916 chr20:23405626 C/G cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1577917 0.958 rs12192546 chr6:86476484 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 6.71 0.34 8.3e-11 Response to antipsychotic treatment; LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.51 0.62 2.44e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg19628046 chr18:33552617 C18orf21 0.52 6.29 0.33 9.87e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg27165867 chr14:105738592 BRF1 -0.49 -7.11 -0.36 7.05e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs796825 0.530 rs2319670 chr3:119996276 T/C cg21790991 chr3:120137480 FSTL1 -0.33 -6.07 -0.32 3.49e-9 HIV-1 susceptibility; LUSC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg26314531 chr2:26401878 FAM59B -0.68 -9.23 -0.45 3.17e-18 Gut microbiome composition (summer); LUSC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg17764715 chr19:33622953 WDR88 0.62 9.16 0.45 5.18e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs116095464 0.558 rs62346506 chr5:201594 T/C cg22857025 chr5:266934 NA -1.2 -14.11 -0.61 8.51e-36 Breast cancer; LUSC cis rs2625529 0.824 rs12906711 chr15:72215065 A/G cg16672083 chr15:72433130 SENP8 -0.52 -7.54 -0.38 4.52e-13 Red blood cell count; LUSC cis rs1595825 0.891 rs112898725 chr2:198650006 C/T cg10547527 chr2:198650123 BOLL -0.51 -5.98 -0.31 5.87e-9 Ulcerative colitis; LUSC cis rs12210905 0.688 rs72839474 chr6:27324757 T/C cg08851530 chr6:28072375 NA 0.9 5.78 0.3 1.75e-8 Hip circumference adjusted for BMI; LUSC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg12310025 chr6:25882481 NA -0.48 -8.08 -0.4 1.24e-14 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs57466243 1 rs57466243 chr17:27059666 T/A cg09479241 chr17:27052676 TLCD1 -0.34 -5.96 -0.31 6.38e-9 Reticulocyte count; LUSC cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg23711669 chr6:146136114 FBXO30 0.92 17.69 0.7 7.02e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs2075165 0.901 rs1043165 chr1:156220056 T/C cg20302342 chr1:156215951 PAQR6 0.33 6.3 0.33 9.13e-10 Tonsillectomy; LUSC cis rs7267979 1.000 rs2856 chr20:25433536 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.63 0.73 1.36e-57 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg23933602 chr10:16859644 RSU1 0.6 7.28 0.37 2.43e-12 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg25072359 chr17:41440525 NA 0.66 9.28 0.45 2.14e-18 Menopause (age at onset); LUSC cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC trans rs57221529 0.766 rs12519469 chr5:581772 A/G cg11887960 chr12:57824829 NA 0.53 6.51 0.34 2.81e-10 Lung disease severity in cystic fibrosis; LUSC cis rs425277 0.916 rs414777 chr1:2101687 G/A cg24578937 chr1:2090814 PRKCZ 0.6 13.87 0.6 7.29e-35 Height; LUSC cis rs7615316 1.000 rs1357530 chr3:142350756 C/T cg16271453 chr3:142027066 XRN1 -0.34 -5.82 -0.3 1.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg12143784 chr7:64541923 NA -0.38 -6.05 -0.31 3.95e-9 Calcium levels; LUSC cis rs2797160 1.000 rs984040 chr6:126021277 A/G cg05901451 chr6:126070800 HEY2 0.57 8.8 0.43 7.65e-17 Endometrial cancer; LUSC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg06850241 chr22:41845214 NA 0.31 5.86 0.31 1.13e-8 Vitiligo; LUSC cis rs2274273 0.840 rs7153110 chr14:55820628 A/G cg04306507 chr14:55594613 LGALS3 0.57 13.21 0.59 2.46e-32 Protein biomarker; LUSC cis rs9309711 0.772 rs9752251 chr2:3489869 C/T cg10845886 chr2:3471009 TTC15 -0.52 -6.97 -0.36 1.71e-11 Neurofibrillary tangles; LUSC cis rs734999 0.549 rs2764845 chr1:2528999 G/T cg18932078 chr1:2524107 MMEL1 -0.29 -6.44 -0.33 4.14e-10 Ulcerative colitis; LUSC cis rs35146811 0.735 rs858506 chr7:99820050 T/C cg22906224 chr7:99728672 NA -0.5 -6.94 -0.35 2.09e-11 Coronary artery disease; LUSC cis rs2976388 0.647 rs13272904 chr8:143782614 T/C cg17252645 chr8:143867129 LY6D 0.39 6.84 0.35 3.86e-11 Urinary tract infection frequency; LUSC cis rs5756813 0.727 rs58765732 chr22:38160794 A/C cg06521852 chr22:38141419 TRIOBP 0.43 6.56 0.34 2.08e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs7829975 0.606 rs7819827 chr8:8797055 G/C cg15556689 chr8:8085844 FLJ10661 -0.6 -9.94 -0.48 1.47e-20 Mood instability; LUSC cis rs13315871 1.000 rs36097398 chr3:58367330 G/A cg12435725 chr3:58293450 RPP14 -0.72 -7.16 -0.36 5.13e-12 Cholesterol, total; LUSC cis rs2860975 1.000 rs2226070 chr10:96776721 C/T cg09036531 chr10:96991505 NA -0.41 -5.69 -0.3 2.75e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs9902453 0.845 rs72823935 chr17:28008595 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.53 0.46 3.29e-19 Coffee consumption (cups per day); LUSC cis rs7590368 0.715 rs72779452 chr2:10959461 G/T cg15705551 chr2:10952987 PDIA6 0.58 6.24 0.32 1.31e-9 Educational attainment (years of education); LUSC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg11752832 chr7:134001865 SLC35B4 0.59 9.15 0.45 5.74e-18 Mean platelet volume; LUSC cis rs478304 0.900 rs502468 chr11:65525119 T/G cg08755490 chr11:65554678 OVOL1 0.4 5.82 0.3 1.4e-8 Acne (severe); LUSC trans rs60843830 1.000 rs55946380 chr2:268293 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.35 0.49 5.71e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs11858210 1 rs11858210 chr15:79078358 G/A cg00540400 chr15:79124168 NA -0.4 -6.97 -0.36 1.71e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.87 -0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs11048434 0.736 rs7301381 chr12:9123932 T/C cg23795048 chr12:9217529 LOC144571 0.34 5.93 0.31 7.77e-9 Sjögren's syndrome; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg00024416 chr22:24240387 NA -0.33 -5.68 -0.3 2.96e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11098499 0.954 rs11098525 chr4:120390152 G/A cg09307838 chr4:120376055 NA 0.79 11.33 0.53 2.2e-25 Corneal astigmatism; LUSC cis rs765787 0.530 rs7167389 chr15:45535683 A/G cg15395560 chr15:45543142 SLC28A2 0.34 5.71 0.3 2.5e-8 Uric acid levels; LUSC trans rs853679 0.517 rs9393891 chr6:28079160 C/T cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC trans rs1459104 0.641 rs12790762 chr11:54933709 T/A cg15704280 chr7:45808275 SEPT13 0.66 5.96 0.31 6.31e-9 Body mass index; LUSC cis rs4268898 0.931 rs2111882 chr2:24434424 A/G cg06627628 chr2:24431161 ITSN2 0.64 9.57 0.46 2.49e-19 Asthma; LUSC cis rs8062405 0.755 rs111693583 chr16:28583610 C/T cg07382826 chr16:28625726 SULT1A1 0.27 5.82 0.3 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs231513 0.954 rs231479 chr17:41983616 A/G cg26893861 chr17:41843967 DUSP3 -0.53 -6.06 -0.31 3.64e-9 Cognitive function; LUSC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg20243544 chr17:37824526 PNMT 0.45 5.7 0.3 2.69e-8 Glomerular filtration rate (creatinine); LUSC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.94 0.36 2.05e-11 Cystic fibrosis severity; LUSC cis rs4077515 0.967 rs3812558 chr9:139269135 A/G cg14019695 chr9:139328340 INPP5E 0.45 8.14 0.41 7.67e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7582180 0.629 rs74177696 chr2:100938481 C/G cg14675211 chr2:100938903 LONRF2 0.37 5.72 0.3 2.35e-8 Intelligence (multi-trait analysis); LUSC cis rs1048238 0.506 rs10927866 chr1:16175317 C/T cg21385522 chr1:16154831 NA 0.56 8.91 0.44 3.29e-17 Systolic blood pressure; LUSC trans rs7824557 0.564 rs12550129 chr8:11233917 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.37 -0.33 6.16e-10 Retinal vascular caliber; LUSC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.11 0.32 2.79e-9 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg03213289 chr20:61660250 NA 0.67 13.61 0.6 7.23e-34 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.546 rs1456207 chr4:98676911 G/A cg05340658 chr4:99064831 C4orf37 0.59 8.88 0.44 4.12e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7215564 0.908 rs2316059 chr17:78663732 C/T cg23238734 chr17:78661607 RPTOR 0.47 6.1 0.32 2.98e-9 Myopia (pathological); LUSC trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -8.22 -0.41 4.54e-15 Neuroticism; LUSC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg15595755 chr5:1867978 NA 0.47 8.71 0.43 1.4e-16 Cardiovascular disease risk factors; LUSC cis rs1670533 1.000 rs2290408 chr4:1067267 A/C cg27284194 chr4:1044797 NA -0.57 -8.93 -0.44 2.9e-17 Recombination rate (females); LUSC cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.18 0.37 4.48e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg08999081 chr20:33150536 PIGU 0.37 6.69 0.34 9.61e-11 Height; LUSC cis rs17756712 0.527 rs1747586 chr6:614375 A/C cg14374089 chr6:596013 EXOC2 0.5 6.69 0.34 9.15e-11 Vertical cup-disc ratio; LUSC cis rs9527 0.662 rs4919686 chr10:104592249 A/C cg15744005 chr10:104629667 AS3MT -0.32 -5.95 -0.31 6.93e-9 Arsenic metabolism; LUSC cis rs478304 0.934 rs506853 chr11:65521247 C/T cg05805236 chr11:65401703 PCNXL3 0.4 6.79 0.35 5.06e-11 Acne (severe); LUSC cis rs12586317 0.620 rs8021414 chr14:35581480 T/A cg05294307 chr14:35346193 BAZ1A -0.57 -7.05 -0.36 1.03e-11 Psoriasis; LUSC cis rs8114671 0.836 rs1885114 chr20:33577361 A/G cg07148914 chr20:33460835 GGT7 -0.44 -6.57 -0.34 1.98e-10 Height; LUSC trans rs1376359 0.537 rs594441 chr1:103264019 T/G cg17154563 chr19:40477487 PSMC4 0.47 5.97 0.31 5.92e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs2204008 0.652 rs11520002 chr12:38022179 G/T cg13010199 chr12:38710504 ALG10B 0.71 10.9 0.51 7.24e-24 Bladder cancer; LUSC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg14784868 chr12:69753453 YEATS4 0.64 9.48 0.46 4.77e-19 Blood protein levels; LUSC trans rs35110281 0.715 rs2838353 chr21:45119228 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 9.12 0.45 7.26e-18 Mean corpuscular volume; LUSC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.16 16.28 0.67 2.76e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg19875535 chr5:140030758 IK -0.55 -8.95 -0.44 2.52e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs61931739 0.500 rs11053236 chr12:34507962 C/G cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.57e-10 Morning vs. evening chronotype; LUSC trans rs6598955 0.671 rs10902727 chr1:26597781 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.56 -0.42 4.22e-16 Obesity-related traits; LUSC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg23262073 chr20:60523788 NA -0.5 -7.08 -0.36 8.41e-12 Body mass index; LUSC cis rs9581857 0.547 rs9581870 chr13:28083957 T/G cg22138327 chr13:27999177 GTF3A 0.65 6.86 0.35 3.45e-11 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg10523679 chr1:76189770 ACADM 0.9 13.04 0.58 1.02e-31 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6842047 0.706 rs4862666 chr4:187136307 A/G cg00427296 chr17:8534932 MYH10 -0.54 -6.03 -0.31 4.38e-9 Blood protein levels; LUSC cis rs30380 0.632 rs26500 chr5:96133712 A/C cg16492584 chr5:96139282 ERAP1 -0.56 -7.56 -0.38 3.84e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg24733560 chr20:60626293 TAF4 0.41 6.75 0.35 6.46e-11 Body mass index; LUSC cis rs6547741 1.000 rs6706610 chr2:27778091 G/A cg12559939 chr2:27858050 GPN1 0.41 6.41 0.33 5e-10 Oral cavity cancer; LUSC trans rs8002861 0.664 rs9533686 chr13:44468494 A/G cg12856521 chr11:46389249 DGKZ 0.43 6.41 0.33 4.88e-10 Leprosy; LUSC cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg04990556 chr1:26633338 UBXN11 -0.82 -15.32 -0.64 1.72e-40 Obesity-related traits; LUSC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg19622623 chr12:86230825 RASSF9 -0.45 -6.22 -0.32 1.53e-9 Major depressive disorder; LUSC cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.17 0.37 4.94e-12 Cognitive ability; LUSC trans rs7615952 0.641 rs6438951 chr3:125696999 A/G cg07211511 chr3:129823064 LOC729375 -0.81 -10.75 -0.51 2.48e-23 Blood pressure (smoking interaction); LUSC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg08888203 chr3:10149979 C3orf24 0.45 6.83 0.35 4.08e-11 Alzheimer's disease; LUSC cis rs11098499 0.505 rs75122014 chr4:120362426 G/C cg09307838 chr4:120376055 NA 0.78 11.2 0.52 6.08e-25 Corneal astigmatism; LUSC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg14552801 chr7:65878734 NA 0.44 6.3 0.33 9.33e-10 Aortic root size; LUSC cis rs7824557 0.603 rs6995404 chr8:11182148 C/G cg21293242 chr8:11204541 TDH 0.33 6.32 0.33 8.31e-10 Retinal vascular caliber; LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg18758796 chr5:131593413 PDLIM4 -0.42 -6.76 -0.35 6.25e-11 Breast cancer; LUSC cis rs7940866 0.838 rs12790299 chr11:130803634 A/G cg12179176 chr11:130786555 SNX19 0.65 9.94 0.48 1.5e-20 Schizophrenia; LUSC cis rs72781680 0.898 rs72782126 chr2:24039901 A/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs11992162 0.967 rs7461062 chr8:11831948 T/C cg21775007 chr8:11205619 TDH 0.54 7.52 0.38 5.09e-13 Monocyte count; LUSC cis rs870825 0.616 rs4615214 chr4:185624129 G/C cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs76419734 0.510 rs3943980 chr4:106676766 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.57 -6.5 -0.34 2.9e-10 Post bronchodilator FEV1; LUSC cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg17063962 chr7:91808500 NA 0.56 8.6 0.43 3.04e-16 Breast cancer; LUSC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg03609598 chr5:56110824 MAP3K1 -0.42 -6.19 -0.32 1.79e-9 Initial pursuit acceleration; LUSC trans rs7937682 0.921 rs10891280 chr11:111433609 A/T cg18187862 chr3:45730750 SACM1L -0.53 -6.54 -0.34 2.33e-10 Primary sclerosing cholangitis; LUSC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg13939156 chr17:80058883 NA 0.34 6.64 0.34 1.27e-10 Life satisfaction; LUSC cis rs6005807 0.719 rs12165893 chr22:29033545 T/C cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2295359 1.000 rs11465754 chr1:67631431 A/G cg03340356 chr1:67600835 NA 0.39 6.37 0.33 6.14e-10 Psoriasis; LUSC cis rs1348850 0.651 rs4893821 chr2:178229352 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.45 -6.45 -0.33 3.96e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6964587 1.000 rs6953515 chr7:91658620 C/T cg17063962 chr7:91808500 NA 0.56 8.68 0.43 1.72e-16 Breast cancer; LUSC cis rs17253792 0.822 rs77415412 chr14:56154146 A/G cg01858014 chr14:56050164 KTN1 -0.82 -6.77 -0.35 5.9e-11 Putamen volume; LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg09455208 chr3:40491958 NA 0.53 9.59 0.46 2.07e-19 Renal cell carcinoma; LUSC cis rs713587 0.571 rs2438679 chr2:25317653 C/T cg01884057 chr2:25150051 NA -0.27 -5.84 -0.3 1.26e-8 Body mass index in non-asthmatics; LUSC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg12310025 chr6:25882481 NA 0.43 7.29 0.37 2.2e-12 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg05855489 chr10:104503620 C10orf26 -0.71 -10.35 -0.49 5.72e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs35851103 0.600 rs4841662 chr8:11843758 A/G cg15556689 chr8:8085844 FLJ10661 -0.63 -9.99 -0.48 1.01e-20 Neuroticism; LUSC cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg04362960 chr10:104952993 NT5C2 0.6 9.71 0.47 8.52e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs950776 0.593 rs621849 chr15:78872861 G/A cg22563815 chr15:78856949 CHRNA5 -0.25 -6.03 -0.31 4.36e-9 Sudden cardiac arrest; LUSC cis rs16912285 0.688 rs11827298 chr11:24324000 G/A ch.11.24196551F chr11:24239977 NA 0.9 9.52 0.46 3.58e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg22681709 chr2:178499509 PDE11A -0.6 -11.81 -0.54 3.82e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg06784218 chr1:46089804 CCDC17 -0.5 -9.46 -0.46 5.75e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg18904891 chr8:8559673 CLDN23 0.61 8.43 0.42 1.05e-15 Obesity-related traits; LUSC cis rs6546886 0.912 rs6745792 chr2:74284033 G/A cg14702570 chr2:74259524 NA -0.31 -5.83 -0.3 1.31e-8 Dialysis-related mortality; LUSC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg22535103 chr8:58192502 C8orf71 -0.73 -7.31 -0.37 1.94e-12 Developmental language disorder (linguistic errors); LUSC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg18876405 chr7:65276391 NA -0.67 -11.8 -0.54 4.41e-27 Aortic root size; LUSC cis rs9902453 0.904 rs4461132 chr17:28423430 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 10.76 0.51 2.17e-23 Coffee consumption (cups per day); LUSC cis rs394563 0.726 rs366905 chr6:149735097 T/A cg03678062 chr6:149772716 ZC3H12D -0.32 -6.63 -0.34 1.34e-10 Dupuytren's disease; LUSC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg01181863 chr3:195395398 SDHAP2 -0.6 -8.15 -0.41 7.43e-15 Pancreatic cancer; LUSC cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg04727924 chr7:799746 HEATR2 -0.55 -6.75 -0.35 6.66e-11 Cerebrospinal P-tau181p levels; LUSC cis rs1595825 0.891 rs16824376 chr2:198684342 C/T cg10547527 chr2:198650123 BOLL -0.51 -5.9 -0.31 8.72e-9 Ulcerative colitis; LUSC cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.51 -0.42 5.93e-16 Chronic sinus infection; LUSC cis rs778371 0.630 rs13007579 chr2:233725364 G/A cg08000102 chr2:233561755 GIGYF2 -0.79 -12.61 -0.57 4.31e-30 Schizophrenia; LUSC cis rs9359856 0.517 rs72919948 chr6:90509389 C/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.22 -0.41 4.65e-15 Bipolar disorder; LUSC cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg01028140 chr2:1542097 TPO -0.6 -8.18 -0.41 5.94e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs72781680 1.000 rs6751655 chr2:24155478 A/G cg08917208 chr2:24149416 ATAD2B 1.01 10.6 0.5 7.75e-23 Lymphocyte counts; LUSC cis rs2479724 0.901 rs33954419 chr6:41786136 A/G cg17623882 chr6:41773611 USP49 -0.64 -10.74 -0.51 2.65e-23 Menarche (age at onset); LUSC cis rs2346177 0.513 rs1530625 chr2:46658067 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.61 -9.71 -0.47 8.36e-20 HDL cholesterol; LUSC cis rs2835872 0.861 rs8126563 chr21:39052624 C/T cg20424643 chr21:39039972 KCNJ6 0.44 6.84 0.35 3.71e-11 Electroencephalographic traits in alcoholism; LUSC cis rs7202877 0.706 rs247450 chr16:75490017 C/A cg04384234 chr16:75411784 CFDP1 0.66 8.56 0.42 4.08e-16 Type 2 diabetes;Type 1 diabetes; LUSC trans rs9291683 0.704 rs11726271 chr4:10098192 G/A cg26043149 chr18:55253948 FECH -0.54 -8.09 -0.4 1.13e-14 Bone mineral density; LUSC trans rs3960554 0.808 rs111714534 chr7:75748896 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 9.42 0.46 7.54e-19 Eotaxin levels; LUSC cis rs34779708 0.931 rs79749947 chr10:35277081 A/T cg04310649 chr10:35416472 CREM -0.43 -6.38 -0.33 5.89e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg02167203 chr6:41068553 NFYA;LOC221442 0.39 5.82 0.3 1.35e-8 Alzheimer's disease (late onset); LUSC cis rs617219 0.819 rs6453434 chr5:78570219 G/T cg24856658 chr5:78533917 JMY 0.31 6.0 0.31 5.2e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg10523679 chr1:76189770 ACADM -0.87 -11.82 -0.54 3.63e-27 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC trans rs4332037 0.539 rs868754 chr7:2033780 G/C cg25206134 chr2:45395956 NA 0.59 6.5 0.34 2.95e-10 Bipolar disorder; LUSC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg17554472 chr22:41940697 POLR3H -0.47 -5.74 -0.3 2.18e-8 Vitiligo; LUSC cis rs7267979 1.000 rs6115182 chr20:25410259 G/A cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25530631 chr11:61100500 DDB1;DAK -0.41 -6.02 -0.31 4.51e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 13.0 0.58 1.5e-31 Alzheimer's disease; LUSC cis rs2580764 0.566 rs2968794 chr2:55290651 C/G cg09592903 chr2:55203963 RTN4 -0.48 -9.92 -0.48 1.76e-20 Mean platelet volume; LUSC trans rs9467711 0.722 rs13201782 chr6:26651053 T/A cg06606381 chr12:133084897 FBRSL1 -0.9 -7.7 -0.39 1.51e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg05855489 chr10:104503620 C10orf26 0.58 9.25 0.45 2.73e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs28374715 0.662 rs691907 chr15:41474657 C/G cg18705301 chr15:41695430 NDUFAF1 0.81 14.85 0.63 1.19e-38 Ulcerative colitis; LUSC cis rs7267979 0.549 rs6138536 chr20:25182648 A/G cg08601574 chr20:25228251 PYGB 0.44 6.73 0.35 7.59e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7408868 1.000 rs1548554 chr19:15277938 C/T cg14696996 chr19:15285081 NOTCH3 0.96 9.25 0.45 2.69e-18 Pulse pressure; LUSC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg19622623 chr12:86230825 RASSF9 -0.42 -6.01 -0.31 4.85e-9 Major depressive disorder; LUSC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.53 0.46 3.44e-19 Bipolar disorder; LUSC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg12257692 chr3:49977190 RBM6 0.24 6.67 0.34 1.06e-10 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.8 -0.43 7.27e-17 Monocyte percentage of white cells; LUSC cis rs250677 0.687 rs40149 chr5:148444275 A/T cg18129178 chr5:148520854 ABLIM3 -0.69 -10.61 -0.5 7.34e-23 Breast cancer; LUSC cis rs2898290 0.592 rs2736342 chr8:11347289 A/C cg21775007 chr8:11205619 TDH -0.47 -6.82 -0.35 4.4e-11 Systolic blood pressure; LUSC cis rs2540226 0.788 rs12623462 chr2:39977265 T/C cg23576258 chr2:39999331 THUMPD2 0.34 5.79 0.3 1.65e-8 Personality dimensions; LUSC cis rs11098499 0.863 rs10009626 chr4:120470005 T/C cg09307838 chr4:120376055 NA 0.76 11.04 0.52 2.31e-24 Corneal astigmatism; LUSC cis rs12410462 0.581 rs113827839 chr1:227547180 C/T cg04117972 chr1:227635322 NA 0.6 6.68 0.34 1e-10 Major depressive disorder; LUSC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg06028605 chr16:24865363 SLC5A11 -0.68 -10.88 -0.51 8.33e-24 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg05340658 chr4:99064831 C4orf37 0.66 11.25 0.52 4.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC cis rs2692947 0.673 rs4907279 chr2:96399968 G/C cg23100626 chr2:96804247 ASTL 0.3 6.96 0.36 1.81e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07626433 chr4:141071632 MAML3 -0.42 -6.26 -0.32 1.16e-9 Hepatitis; LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.89 0.31 9.61e-9 Menopause (age at onset); LUSC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg18230493 chr5:56204884 C5orf35 -0.79 -12.49 -0.56 1.27e-29 Initial pursuit acceleration; LUSC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg17554472 chr22:41940697 POLR3H 0.47 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs12579753 0.879 rs11115008 chr12:82164859 C/T cg21231944 chr12:82153410 PPFIA2 -0.38 -5.99 -0.31 5.3e-9 Resting heart rate; LUSC cis rs7216064 0.684 rs7406031 chr17:66021753 C/T cg12091567 chr17:66097778 LOC651250 0.88 14.18 0.61 4.62e-36 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg27446573 chr6:127587934 RNF146 0.59 9.41 0.46 8.36e-19 Breast cancer; LUSC trans rs7647973 0.593 rs55997059 chr3:49858661 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.62 0.38 2.61e-13 Menarche (age at onset); LUSC cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs2050392 0.931 rs2265189 chr10:30689316 C/T cg18806716 chr10:30721971 MAP3K8 0.38 6.23 0.32 1.42e-9 Inflammatory bowel disease; LUSC cis rs1044826 1.000 rs9849578 chr3:139089602 C/T cg00490450 chr3:139108681 COPB2 0.55 7.37 0.37 1.34e-12 Obesity-related traits; LUSC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg07395648 chr5:131743802 NA -0.41 -6.42 -0.33 4.76e-10 Breast cancer;Mosquito bite size; LUSC cis rs868036 1.000 rs4776974 chr15:68095927 G/A cg08079166 chr15:68083412 MAP2K5 0.4 8.32 0.41 2.2e-15 Restless legs syndrome; LUSC cis rs62244186 0.535 rs59726036 chr3:44850074 G/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.53 8.35 0.42 1.78e-15 Depressive symptoms; LUSC cis rs6714710 0.603 rs12995673 chr2:98409046 G/A cg26665480 chr2:98280029 ACTR1B 0.63 9.17 0.45 5.08e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs1941687 0.797 rs2976 chr18:31403254 T/C cg27147174 chr7:100797783 AP1S1 -0.46 -6.92 -0.35 2.29e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs34779708 0.931 rs35848945 chr10:35287561 G/T cg04310649 chr10:35416472 CREM -0.41 -6.14 -0.32 2.29e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg16797656 chr11:68205561 LRP5 0.4 7.21 0.37 3.68e-12 Total body bone mineral density; LUSC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg09263875 chr16:632152 PIGQ 0.71 13.18 0.59 3.08e-32 Height; LUSC cis rs75804782 0.521 rs58568091 chr2:239430582 G/A cg18131467 chr2:239335373 ASB1 -0.66 -5.95 -0.31 6.8e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs73110464 0.609 rs4919752 chr12:53359229 G/C cg16329197 chr12:53359506 NA -0.63 -8.63 -0.43 2.49e-16 Cancer (pleiotropy); LUSC cis rs2370759 1.000 rs79806114 chr10:32618022 T/C cg01819863 chr10:32635814 EPC1 1.08 13.27 0.59 1.47e-32 Sexual dysfunction (female); LUSC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg14004847 chr7:1930337 MAD1L1 -0.6 -9.11 -0.45 7.68e-18 Schizophrenia; LUSC cis rs6121246 0.567 rs6120890 chr20:30207659 T/G cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.23e-10 Mean corpuscular hemoglobin; LUSC cis rs4622329 0.615 rs4764672 chr12:102289215 A/G cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg13010199 chr12:38710504 ALG10B 0.67 10.36 0.49 5.56e-22 Heart rate; LUSC trans rs62238980 0.614 rs117432936 chr22:32382309 G/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs11148252 0.553 rs9536219 chr13:53227301 C/T cg00495681 chr13:53174319 NA 0.8 15.19 0.64 5.46e-40 Lewy body disease; LUSC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg03036452 chr22:46663545 TTC38 0.52 5.68 0.3 2.85e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16424519 chr16:21531031 SLC7A5P2 0.44 5.95 0.31 6.75e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6547741 0.967 rs4665999 chr2:27834444 T/C cg12559939 chr2:27858050 GPN1 0.41 6.48 0.33 3.28e-10 Oral cavity cancer; LUSC cis rs4595586 0.545 rs12820138 chr12:39357049 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC cis rs10875595 0.836 rs6868387 chr5:140660814 G/A cg24830062 chr5:140700576 TAF7 -0.52 -6.29 -0.33 1e-9 Pulmonary function decline; LUSC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.61e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.79 0.39 8.73e-14 Prudent dietary pattern; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg15147215 chr3:52552868 STAB1 -0.32 -6.49 -0.33 3.07e-10 Electroencephalogram traits; LUSC trans rs2790216 0.526 rs1199093 chr10:59896794 C/G cg04559609 chr1:101361710 SLC30A7;EXTL2 -0.36 -5.96 -0.31 6.29e-9 Inflammatory bowel disease; LUSC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg18230493 chr5:56204884 C5orf35 0.9 13.5 0.59 1.85e-33 Initial pursuit acceleration; LUSC cis rs26868 0.690 rs26835 chr16:2237549 C/T cg27608139 chr16:2294856 DCI 0.33 5.8 0.3 1.53e-8 Height; LUSC cis rs6696846 0.765 rs11577406 chr1:205065733 G/T cg03948781 chr1:205179583 DSTYK 0.32 6.24 0.32 1.33e-9 Red blood cell count; LUSC cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg23711669 chr6:146136114 FBXO30 0.71 12.32 0.56 5.36e-29 Lobe attachment (rater-scored or self-reported); LUSC trans rs1814175 0.645 rs28627251 chr11:50048125 G/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs2692947 0.655 rs4605406 chr2:96583735 A/C cg22654517 chr2:96458247 NA 0.37 6.82 0.35 4.36e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg08999081 chr20:33150536 PIGU 0.37 6.69 0.34 9.61e-11 Height; LUSC cis rs440932 0.565 rs19334 chr8:9009906 C/T cg06636001 chr8:8085503 FLJ10661 0.42 6.28 0.32 1.06e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg19077165 chr18:44547161 KATNAL2 -0.38 -5.71 -0.3 2.45e-8 Personality dimensions; LUSC trans rs1493916 0.905 rs7239283 chr18:31395397 G/A cg15819921 chr19:927150 ARID3A -0.43 -6.36 -0.33 6.54e-10 Life satisfaction; LUSC cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg11645453 chr3:52864694 ITIH4 0.47 10.53 0.5 1.41e-22 Schizophrenia; LUSC cis rs7903847 0.642 rs11189206 chr10:99167802 T/C cg20016023 chr10:99160130 RRP12 -0.3 -7.45 -0.38 7.84e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs113835537 0.529 rs11227495 chr11:66263243 C/T cg24851651 chr11:66362959 CCS 0.54 8.08 0.4 1.17e-14 Airway imaging phenotypes; LUSC cis rs861020 0.563 rs61820640 chr1:210041297 G/T cg05527609 chr1:210001259 C1orf107 -0.86 -11.31 -0.53 2.55e-25 Orofacial clefts; LUSC cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.59 -0.46 2.18e-19 Chronic sinus infection; LUSC cis rs7615316 0.934 rs6440089 chr3:142279796 T/C cg16271453 chr3:142027066 XRN1 -0.37 -6.47 -0.33 3.43e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.92 0.44 3.2e-17 Motion sickness; LUSC cis rs7000551 0.751 rs2449338 chr8:22369232 A/G cg12081754 chr8:22256438 SLC39A14 0.42 6.14 0.32 2.28e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs6502050 0.799 rs7501461 chr17:80109806 C/T cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs6500395 0.890 rs3843724 chr16:48618573 C/G cg04672837 chr16:48644449 N4BP1 0.49 7.09 0.36 7.99e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2224391 0.628 rs2753244 chr6:5257610 T/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.49 -6.1 -0.32 3.01e-9 Height; LUSC cis rs9527 0.640 rs7089061 chr10:104723015 C/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.68 -0.34 1e-10 Arsenic metabolism; LUSC cis rs12594515 1.000 rs12185095 chr15:45994635 G/T cg06207120 chr15:45996521 NA 0.38 5.85 0.3 1.16e-8 Waist circumference;Weight; LUSC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9611519 1.000 rs5751069 chr22:41627775 C/G cg13813247 chr22:41461852 NA -0.33 -5.84 -0.3 1.26e-8 Neuroticism; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg02475777 chr4:1388615 CRIPAK 0.45 6.76 0.35 6.03e-11 Obesity-related traits; LUSC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg06212747 chr3:49208901 KLHDC8B 0.44 5.98 0.31 5.79e-9 Parkinson's disease; LUSC cis rs1044826 0.642 rs2118981 chr3:139178853 A/G cg00490450 chr3:139108681 COPB2 0.46 7.11 0.36 6.89e-12 Obesity-related traits; LUSC cis rs6542838 0.641 rs4851176 chr2:99534859 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.62 -0.34 1.44e-10 Fear of minor pain; LUSC cis rs3862030 0.720 rs7081467 chr10:104231662 G/C cg05855489 chr10:104503620 C10orf26 0.48 7.28 0.37 2.41e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs4308124 0.708 rs28871990 chr2:111962441 G/A cg04571233 chr2:111982156 NA -0.5 -6.55 -0.34 2.11e-10 Vitiligo; LUSC trans rs890100 0.769 rs1978534 chr2:56716404 G/A cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.62e-9 Gut microbiome composition (summer); LUSC cis rs7572644 0.713 rs4666021 chr2:28055881 A/G cg27432699 chr2:27873401 GPN1 0.52 6.73 0.35 7.41e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg05855489 chr10:104503620 C10orf26 -0.69 -9.84 -0.47 3.15e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs2404602 0.684 rs3910756 chr15:76945369 C/T cg23625390 chr15:77176239 SCAPER -0.61 -8.98 -0.44 2.03e-17 Blood metabolite levels; LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg21280719 chr6:42927975 GNMT -0.32 -7.93 -0.4 3.42e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7215564 0.908 rs74000898 chr17:78653532 A/C cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs701145 0.585 rs62276840 chr3:153783622 G/C cg17054900 chr3:154042577 DHX36 -0.73 -7.44 -0.38 8.72e-13 Coronary artery disease; LUSC cis rs79387448 0.745 rs17027413 chr2:103153667 A/G cg09003973 chr2:102972529 NA -0.88 -8.2 -0.41 5.26e-15 Gut microbiota (bacterial taxa); LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7917772 0.560 rs11595170 chr10:104339851 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.7 -0.51 3.58e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg09763514 chr7:2298050 SNX8 -0.42 -6.39 -0.33 5.69e-10 Mosquito bite size; LUSC trans rs10221833 0.636 rs355891 chr2:165634983 T/C cg26993132 chr16:89239499 CDH15 0.31 5.99 0.31 5.47e-9 Response to statin therapy; LUSC trans rs9944715 1.000 rs6507690 chr18:43808597 A/G cg01718231 chr17:29326311 RNF135 -0.53 -7.33 -0.37 1.76e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg24060327 chr5:131705240 SLC22A5 -0.53 -8.88 -0.44 4.11e-17 Breast cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04422289 chr4:48833305 OCIAD1 -0.44 -6.08 -0.32 3.25e-9 Electrocardiographic conduction measures; LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.33 0.37 1.72e-12 Platelet count; LUSC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg27165867 chr14:105738592 BRF1 -0.51 -7.21 -0.37 3.77e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs2820315 1.000 rs2820312 chr1:201869257 G/A cg10061532 chr1:201886748 LMOD1 0.28 6.17 0.32 2.03e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg21153622 chr11:89784906 NA -0.39 -6.13 -0.32 2.5e-9 Coronary artery disease; LUSC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg09877947 chr5:131593287 PDLIM4 0.46 7.44 0.38 8.87e-13 Breast cancer; LUSC cis rs981844 0.740 rs6858578 chr4:154682058 G/T cg14289246 chr4:154710475 SFRP2 -0.5 -7.2 -0.37 3.92e-12 Response to statins (LDL cholesterol change); LUSC cis rs2625529 0.761 rs4776582 chr15:72207520 A/T cg16672083 chr15:72433130 SENP8 -0.5 -7.35 -0.37 1.56e-12 Red blood cell count; LUSC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg19678392 chr7:94953810 PON1 -0.35 -5.68 -0.3 2.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg14004847 chr7:1930337 MAD1L1 -0.49 -7.53 -0.38 4.8e-13 Bipolar disorder and schizophrenia; LUSC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg24733560 chr20:60626293 TAF4 0.43 7.85 0.39 5.6e-14 Body mass index; LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg08742575 chr21:47604166 C21orf56 0.43 6.51 0.34 2.78e-10 Testicular germ cell tumor; LUSC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg09034736 chr1:150693464 HORMAD1 0.43 6.08 0.32 3.32e-9 Melanoma; LUSC cis rs7937682 0.924 rs489783 chr11:111520522 A/G cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs637571 0.584 rs594689 chr11:65635559 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.51 -6.88 -0.35 3.03e-11 Eosinophil percentage of white cells; LUSC cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.81 0.43 6.77e-17 Axial length; LUSC cis rs2120019 0.508 rs8030528 chr15:75171825 C/T cg09165964 chr15:75287851 SCAMP5 -0.94 -11.65 -0.54 1.46e-26 Blood trace element (Zn levels); LUSC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg13770153 chr20:60521292 NA -0.62 -8.16 -0.41 6.68e-15 Body mass index; LUSC cis rs10751667 0.600 rs11246376 chr11:999622 C/T cg06064525 chr11:970664 AP2A2 -0.31 -6.09 -0.32 3.07e-9 Alzheimer's disease (late onset); LUSC cis rs6519955 0.765 rs7292527 chr22:46423125 G/T cg05468064 chr22:46423449 NA -0.43 -6.75 -0.35 6.62e-11 Dupuytren's disease; LUSC cis rs6456156 0.792 rs7775443 chr6:167513252 A/C cg07741184 chr6:167504864 NA -0.38 -6.66 -0.34 1.15e-10 Primary biliary cholangitis; LUSC cis rs2197308 0.623 rs1672426 chr12:38118671 C/T cg13010199 chr12:38710504 ALG10B -0.51 -7.72 -0.39 1.33e-13 Morning vs. evening chronotype; LUSC cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg18252515 chr7:66147081 NA -1.23 -14.09 -0.61 1.07e-35 Diabetic kidney disease; LUSC cis rs17401966 1.000 rs3753037 chr1:10355834 C/T cg19773385 chr1:10388646 KIF1B -0.54 -8.43 -0.42 1.03e-15 Hepatocellular carcinoma; LUSC cis rs929596 1.000 rs929596 chr2:234674476 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.71 -11.69 -0.54 1.06e-26 Total bilirubin levels in HIV-1 infection; LUSC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg23758822 chr17:41437982 NA 1.06 22.0 0.77 6.35e-67 Menopause (age at onset); LUSC cis rs926938 0.505 rs360593 chr1:115472265 T/G cg01522456 chr1:115632236 TSPAN2 -0.41 -6.43 -0.33 4.47e-10 Autism; LUSC trans rs8073060 0.586 rs72829923 chr17:34045089 T/A cg19694781 chr19:47549865 TMEM160 1.14 18.04 0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2540226 0.539 rs2716694 chr2:39911336 A/G cg23576258 chr2:39999331 THUMPD2 0.35 5.76 0.3 1.89e-8 Personality dimensions; LUSC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg21862992 chr11:68658383 NA 0.5 7.99 0.4 2.28e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.61 -0.34 1.51e-10 Arsenic metabolism; LUSC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg18225595 chr11:63971243 STIP1 0.63 10.91 0.51 6.77e-24 Platelet count; LUSC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg13902645 chr11:5959945 NA -0.6 -8.44 -0.42 9.71e-16 DNA methylation (variation); LUSC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg15212455 chr7:39170539 POU6F2 0.66 11.53 0.53 4.21e-26 IgG glycosylation; LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg02951883 chr7:2050386 MAD1L1 -0.59 -10.93 -0.51 5.62e-24 Bipolar disorder and schizophrenia; LUSC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg27432699 chr2:27873401 GPN1 -0.58 -8.64 -0.43 2.41e-16 Total body bone mineral density; LUSC cis rs6582630 0.555 rs7294313 chr12:38323603 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.51 -0.34 2.82e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg03929089 chr4:120376271 NA 0.68 7.56 0.38 4.05e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg01741372 chr11:783889 NA -0.51 -9.2 -0.45 3.84e-18 Breast cancer; LUSC cis rs8032315 0.965 rs8027450 chr15:91418394 C/T cg05469396 chr15:91419421 FURIN -0.42 -6.7 -0.34 8.98e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7681440 0.904 rs2301135 chr4:90758389 G/C cg15133208 chr4:90757351 SNCA -0.32 -5.72 -0.3 2.32e-8 Dementia with Lewy bodies; LUSC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg09034736 chr1:150693464 HORMAD1 0.4 5.72 0.3 2.34e-8 Melanoma; LUSC trans rs80093141 0.575 rs17108513 chr14:39356146 A/G cg08262584 chr8:54154426 OPRK1 0.44 6.08 0.32 3.21e-9 Common carotid intima-media thickness in HIV infection; LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2197308 0.594 rs9705810 chr12:37895003 G/A cg13010199 chr12:38710504 ALG10B -0.57 -8.69 -0.43 1.71e-16 Morning vs. evening chronotype; LUSC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg20891283 chr12:69753455 YEATS4 0.93 18.04 0.7 2.85e-51 Cerebrospinal fluid biomarker levels; LUSC trans rs1814175 0.935 rs11040462 chr11:49683158 G/A cg15704280 chr7:45808275 SEPT13 -1.09 -22.46 -0.78 1.02e-68 Height; LUSC cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg07274523 chr3:49395745 GPX1 0.68 10.63 0.5 6.13e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg05738196 chr6:26577821 NA 0.53 8.32 0.41 2.23e-15 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22658884 chr19:14192470 NA 0.51 6.96 0.36 1.78e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17125944 0.686 rs2296495 chr14:53379878 G/A cg00686598 chr14:53173677 PSMC6 0.84 7.57 0.38 3.6e-13 Alzheimer's disease (late onset); LUSC trans rs35110281 0.714 rs2282526 chr21:45080552 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.47 0.53 6.76e-26 Mean corpuscular volume; LUSC cis rs1559088 0.803 rs10405770 chr19:33616549 C/T cg27124370 chr19:33622961 WDR88 0.54 7.16 0.36 5.12e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9303401 0.659 rs34468504 chr17:56648277 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC cis rs1030877 0.515 rs2679893 chr2:105909554 A/G cg02079111 chr2:105885981 TGFBRAP1 0.65 8.95 0.44 2.53e-17 Obesity-related traits; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg23102388 chr7:1867652 MAD1L1 -0.3 -5.68 -0.3 2.97e-8 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18099408 chr3:52552593 STAB1 -0.4 -6.79 -0.35 5.01e-11 Bipolar disorder; LUSC cis rs2073300 0.609 rs2295238 chr20:23387946 C/G cg12062639 chr20:23401060 NAPB 0.88 7.84 0.39 5.96e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg04414720 chr1:150670196 GOLPH3L 0.52 8.27 0.41 3.27e-15 Melanoma; LUSC trans rs11923600 0.793 rs62285823 chr3:175891124 C/G cg02188190 chr13:112894616 NA 0.45 6.37 0.33 6.1e-10 Height; LUSC cis rs5769707 0.642 rs135880 chr22:50018654 T/A cg10356904 chr22:49881777 NA -0.3 -6.19 -0.32 1.74e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8060686 0.623 rs58388686 chr16:68075439 A/G cg26727032 chr16:67993705 SLC12A4 -0.42 -6.56 -0.34 2.06e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg00750074 chr16:89608354 SPG7 0.42 7.01 0.36 1.31e-11 Multiple myeloma (IgH translocation); LUSC cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs6028335 0.502 rs7265661 chr20:37586842 G/T cg27552599 chr20:37590471 DHX35 0.45 7.34 0.37 1.68e-12 Alcohol and nicotine co-dependence; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16066221 chr17:28512115 CCDC55 0.44 6.7 0.34 9.01e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg04800585 chr6:26043546 HIST1H2BB 0.43 6.07 0.32 3.4e-9 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg07741184 chr6:167504864 NA 0.34 6.18 0.32 1.86e-9 Crohn's disease; LUSC trans rs61931739 0.500 rs7306435 chr12:34482933 A/G cg13010199 chr12:38710504 ALG10B -0.68 -10.73 -0.51 2.72e-23 Morning vs. evening chronotype; LUSC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11890956 chr21:40555474 PSMG1 -0.83 -14.73 -0.63 3.56e-38 Cognitive function; LUSC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg19748678 chr4:122722346 EXOSC9 0.49 7.57 0.38 3.59e-13 Type 2 diabetes; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg06145435 chr7:1022769 CYP2W1 0.31 6.3 0.33 9.28e-10 Longevity;Endometriosis; LUSC cis rs11785400 0.701 rs9721143 chr8:143727511 A/T cg24634471 chr8:143751801 JRK 0.51 7.21 0.37 3.71e-12 Schizophrenia; LUSC trans rs17685 0.712 rs28456330 chr7:75810542 A/G cg19862616 chr7:65841803 NCRNA00174 1.09 18.27 0.71 3.31e-52 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4631830 0.900 rs7914347 chr10:51537431 C/T cg10326726 chr10:51549505 MSMB -0.36 -6.16 -0.32 2.09e-9 Prostate-specific antigen levels; LUSC cis rs3806843 1.000 rs10038174 chr5:140210616 G/A cg26395211 chr5:140044315 WDR55 -0.38 -5.76 -0.3 1.87e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg18404041 chr3:52824283 ITIH1 -0.52 -9.82 -0.47 3.77e-20 Bipolar disorder; LUSC cis rs9811920 0.809 rs6440967 chr3:99722396 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 6.45 0.33 3.83e-10 Axial length; LUSC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19717773 chr7:2847554 GNA12 -0.38 -6.13 -0.32 2.51e-9 Height; LUSC trans rs17685 0.753 rs2302438 chr7:75677065 C/A cg19862616 chr7:65841803 NCRNA00174 1.12 19.81 0.73 2.72e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg05776053 chr2:74358815 NA 0.42 6.27 0.32 1.1e-9 Gestational age at birth (maternal effect); LUSC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg22467129 chr15:76604101 ETFA -0.45 -7.18 -0.37 4.52e-12 Blood metabolite levels; LUSC cis rs7180079 1.000 rs6494477 chr15:64667334 T/C cg08069370 chr15:64387884 SNX1 0.58 6.2 0.32 1.68e-9 Monocyte count; LUSC cis rs7107174 1.000 rs2450131 chr11:77944568 A/C cg02023728 chr11:77925099 USP35 0.51 7.12 0.36 6.48e-12 Testicular germ cell tumor; LUSC cis rs603446 0.935 rs918143 chr11:116630600 C/T cg08985259 chr11:116699649 APOC3 -0.25 -5.67 -0.3 3.13e-8 Triglycerides; LUSC cis rs7940866 0.804 rs10894287 chr11:130808483 C/T cg12179176 chr11:130786555 SNX19 0.62 9.4 0.46 8.93e-19 Schizophrenia; LUSC cis rs2262909 0.962 rs11673195 chr19:22313814 T/C cg11619707 chr19:22235551 ZNF257 0.39 5.95 0.31 6.77e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.66 11.48 0.53 6.12e-26 Menarche (age at onset); LUSC trans rs12200782 0.929 rs72843734 chr6:26448344 C/G cg11837749 chr1:55047332 ACOT11 0.58 6.23 0.32 1.41e-9 Small cell lung carcinoma; LUSC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg22496380 chr5:211416 CCDC127 0.62 7.31 0.37 2.02e-12 Breast cancer; LUSC cis rs1568889 1.000 rs34337978 chr11:28136746 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 8.69 0.43 1.61e-16 Bipolar disorder; LUSC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg12560992 chr17:57184187 TRIM37 0.78 13.83 0.6 1.07e-34 Intelligence (multi-trait analysis); LUSC cis rs2952156 0.959 rs11653998 chr17:37877447 C/G cg20243544 chr17:37824526 PNMT 0.49 6.91 0.35 2.42e-11 Asthma; LUSC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg03161606 chr19:29218774 NA 0.6 8.75 0.43 1.08e-16 Methadone dose in opioid dependence; LUSC cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.45 0.53 7.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs12579753 1.000 rs12580330 chr12:82241280 T/G cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC trans rs7903456 0.648 rs6586053 chr10:88829872 G/T cg16309350 chr10:134983667 KNDC1 0.34 5.97 0.31 6.2e-9 Gout;Renal underexcretion gout; LUSC cis rs4845570 0.749 rs11586446 chr1:151712488 A/G cg07092448 chr1:151763213 TDRKH -1.07 -10.77 -0.51 2.03e-23 Coronary artery disease; LUSC cis rs6754311 0.731 rs3754686 chr2:136603276 T/C cg15123519 chr2:136567270 LCT 0.39 5.93 0.31 7.56e-9 Mosquito bite size; LUSC cis rs4363385 0.818 rs10788853 chr1:153002231 C/T cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC cis rs7100689 0.622 rs1340379 chr10:82121455 G/A cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg23283495 chr1:209979779 IRF6 0.63 7.67 0.39 1.85e-13 Coronary artery disease; LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.53 6.53 0.34 2.46e-10 Renal function-related traits (BUN); LUSC cis rs79387448 0.745 rs59694233 chr2:103116521 G/A cg09003973 chr2:102972529 NA 0.86 8.49 0.42 6.99e-16 Gut microbiota (bacterial taxa); LUSC cis rs1376877 0.519 rs4675332 chr2:204190907 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.47 5.77 0.3 1.82e-8 Subclinical atherosclerosis traits (other); LUSC cis rs6430585 0.583 rs111837148 chr2:136612036 G/A cg07169764 chr2:136633963 MCM6 1.23 19.55 0.73 2.84e-57 Corneal structure; LUSC cis rs6815814 0.950 rs11722889 chr4:38810975 C/T cg02016764 chr4:38805732 TLR1 -0.54 -5.72 -0.3 2.43e-8 Breast cancer; LUSC cis rs10876993 0.890 rs7976852 chr12:58100551 T/G cg18357645 chr12:58087776 OS9 0.57 8.58 0.42 3.74e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg04025307 chr7:1156635 C7orf50 0.43 6.83 0.35 4.02e-11 Longevity;Endometriosis; LUSC cis rs909002 0.962 rs7537646 chr1:32135495 G/A cg13919466 chr1:32135498 COL16A1 -0.32 -5.81 -0.3 1.49e-8 Intelligence (multi-trait analysis); LUSC cis rs2522056 1.000 rs2106854 chr5:131769174 C/T cg24060327 chr5:131705240 SLC22A5 0.47 6.72 0.35 7.82e-11 Lymphocyte counts;Fibrinogen; LUSC cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.6 -0.57 4.72e-30 Chronic sinus infection; LUSC cis rs9300255 0.568 rs1790108 chr12:123636841 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.14 -0.32 2.38e-9 Neutrophil percentage of white cells; LUSC cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14240646 chr10:27532245 ACBD5 0.71 8.18 0.41 5.94e-15 Breast cancer; LUSC cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg23711669 chr6:146136114 FBXO30 -0.82 -14.5 -0.62 2.82e-37 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20110780 chr8:109261090 EIF3E 0.38 6.22 0.32 1.49e-9 Triglycerides; LUSC cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg22782873 chr19:19639568 YJEFN3 -0.51 -6.3 -0.33 9.18e-10 Bipolar disorder; LUSC cis rs244731 0.959 rs6872021 chr5:176610012 G/A cg17509989 chr5:176798049 RGS14 -0.68 -9.64 -0.47 1.48e-19 Urate levels in lean individuals; LUSC trans rs61931739 0.578 rs61927759 chr12:33713297 C/T cg26384229 chr12:38710491 ALG10B -0.42 -6.16 -0.32 2.08e-9 Morning vs. evening chronotype; LUSC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs208520 1.000 rs12190773 chr6:66968194 T/C cg07460842 chr6:66804631 NA 0.96 12.45 0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs9790314 1.000 rs28515190 chr3:161028605 G/A cg04691961 chr3:161091175 C3orf57 -0.36 -6.12 -0.32 2.6e-9 Morning vs. evening chronotype; LUSC cis rs921968 0.613 rs1427445 chr2:219555573 C/A cg02176678 chr2:219576539 TTLL4 -0.59 -10.62 -0.5 6.76e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg13319975 chr6:146136371 FBXO30 0.45 6.99 0.36 1.51e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg23649088 chr2:200775458 C2orf69 0.55 7.39 0.38 1.15e-12 Schizophrenia; LUSC cis rs1322512 0.917 rs2623943 chr6:152951141 A/G cg27316956 chr6:152958899 SYNE1 -0.37 -6.32 -0.33 8.59e-10 Tonometry; LUSC cis rs6546550 0.935 rs11673826 chr2:70041033 G/A cg02498382 chr2:70120550 SNRNP27 -0.29 -6.95 -0.36 1.89e-11 Prevalent atrial fibrillation; LUSC cis rs6733011 0.582 rs2280256 chr2:99449174 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -6.06 -0.31 3.62e-9 Bipolar disorder; LUSC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg23281280 chr6:28129359 ZNF389 0.45 5.67 0.3 3.04e-8 Depression; LUSC cis rs2625529 0.761 rs972028 chr15:72173092 C/T cg16672083 chr15:72433130 SENP8 -0.46 -6.89 -0.35 2.78e-11 Red blood cell count; LUSC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg02524346 chr8:600233 NA -0.94 -9.29 -0.45 2.08e-18 IgG glycosylation; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs73129298 0.551 rs16995010 chr20:48602623 C/G cg25655593 chr20:48599521 SNAI1 -0.56 -6.04 -0.31 4.18e-9 Inflammatory skin disease; LUSC cis rs2404602 0.647 rs11072625 chr15:77084984 A/G cg23625390 chr15:77176239 SCAPER 0.63 9.37 0.46 1.13e-18 Blood metabolite levels; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg01125463 chr6:42946178 PEX6 -0.36 -6.06 -0.31 3.74e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg06784218 chr1:46089804 CCDC17 -0.47 -8.92 -0.44 3.06e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11264799 0.669 rs12082378 chr1:157634567 C/A cg18268488 chr1:157545234 FCRL4 0.33 6.0 0.31 5.27e-9 IgA nephropathy; LUSC cis rs11640533 1.000 rs11640533 chr16:53412862 A/G cg04653913 chr16:53407753 NA -0.45 -7.13 -0.36 6.24e-12 Intelligence (multi-trait analysis); LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC trans rs9291683 0.588 rs6844329 chr4:10018544 T/C cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Bone mineral density; LUSC cis rs738322 0.555 rs2284063 chr22:38544298 C/T cg25457927 chr22:38595422 NA 0.42 8.44 0.42 9.61e-16 Cutaneous nevi; LUSC cis rs1023500 0.573 rs133382 chr22:42471774 C/T cg05082376 chr22:42548792 NA -0.43 -6.5 -0.33 2.98e-10 Schizophrenia; LUSC cis rs7408868 0.908 rs1044006 chr19:15285052 T/C cg14696996 chr19:15285081 NOTCH3 0.95 9.06 0.44 1.14e-17 Pulse pressure; LUSC trans rs4800353 0.929 rs899639 chr18:19608112 T/C cg01841828 chr16:69166849 CHTF8;CIRH1A -0.58 -6.02 -0.31 4.53e-9 Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs2200578 0.841 rs62154623 chr2:99611488 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.62 7.49 0.38 6.26e-13 IgG glycosylation; LUSC cis rs8180040 0.764 rs2132173 chr3:47247060 C/T cg02527881 chr3:46936655 PTH1R 0.41 7.47 0.38 6.86e-13 Colorectal cancer; LUSC cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg14121845 chr20:25566513 NINL 0.31 5.66 0.3 3.21e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4363385 0.567 rs7551791 chr1:153024267 A/T cg00922841 chr1:152955080 SPRR1A -0.38 -6.22 -0.32 1.52e-9 Inflammatory skin disease; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg00684032 chr4:1343700 KIAA1530 0.37 6.47 0.33 3.48e-10 Obesity-related traits; LUSC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg11062466 chr8:58055876 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs10089 1.000 rs4836368 chr5:127486330 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.33 0.56 4.83e-29 Ileal carcinoids; LUSC cis rs1577917 0.771 rs4441928 chr6:86241894 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.52 8.18 0.41 5.84e-15 Response to antipsychotic treatment; LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg04362960 chr10:104952993 NT5C2 0.55 8.12 0.41 9.21e-15 Arsenic metabolism; LUSC cis rs765787 0.530 rs11636018 chr15:45539137 T/C cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC cis rs1670533 1.000 rs13107058 chr4:1054379 G/A cg27284194 chr4:1044797 NA 0.59 8.86 0.44 4.9e-17 Recombination rate (females); LUSC cis rs3540 0.597 rs1978150 chr15:91037041 A/G cg22089800 chr15:90895588 ZNF774 -0.57 -8.3 -0.41 2.68e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg21782813 chr7:2030301 MAD1L1 0.48 7.92 0.4 3.51e-14 Schizophrenia; LUSC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg11871910 chr12:69753446 YEATS4 0.62 9.27 0.45 2.35e-18 Blood protein levels; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.19 0.55 1.64e-28 Prudent dietary pattern; LUSC cis rs2204008 0.528 rs11503820 chr12:38395379 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.72 -0.35 7.96e-11 Bladder cancer; LUSC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3820928 0.874 rs9288618 chr2:227872617 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.64 -0.39 2.35e-13 Pulmonary function; LUSC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg25767906 chr1:53392781 SCP2 0.46 8.12 0.41 8.86e-15 Monocyte count; LUSC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.81 0.3 1.44e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs459571 0.883 rs2520096 chr9:136919416 A/G cg01294253 chr9:136912663 BRD3 0.34 6.07 0.32 3.5e-9 Platelet distribution width; LUSC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.37 0.33 6.32e-10 Lung cancer; LUSC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg04414720 chr1:150670196 GOLPH3L 0.49 7.43 0.38 9.4e-13 Melanoma; LUSC trans rs459571 0.959 rs460888 chr9:136913123 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.76 -12.4 -0.56 2.67e-29 Platelet distribution width; LUSC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg05347473 chr6:146136440 FBXO30 -0.4 -6.76 -0.35 6.3e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9653442 0.712 rs7582731 chr2:100686486 T/C cg07810366 chr2:100720526 AFF3 -0.44 -7.36 -0.37 1.4e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg27170947 chr2:26402098 FAM59B -0.62 -9.26 -0.45 2.58e-18 Gut microbiome composition (summer); LUSC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg07424592 chr7:64974309 NA -0.63 -5.65 -0.3 3.53e-8 Diabetic kidney disease; LUSC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg07701084 chr6:150067640 NUP43 0.57 8.82 0.43 6.43e-17 Lung cancer; LUSC trans rs561341 0.739 rs7213369 chr17:30211878 G/A cg20587970 chr11:113659929 NA 0.77 9.88 0.48 2.27e-20 Hip circumference adjusted for BMI; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21459921 chr20:60878267 ADRM1 -0.52 -6.25 -0.32 1.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg14552801 chr7:65878734 NA 0.38 5.9 0.31 9.1e-9 Aortic root size; LUSC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg18099408 chr3:52552593 STAB1 0.37 6.19 0.32 1.78e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg21770322 chr7:97807741 LMTK2 0.42 7.2 0.37 4.04e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg06784218 chr1:46089804 CCDC17 -0.47 -9.14 -0.45 6.34e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2282032 1.000 rs75816060 chr14:90759470 C/T cg14092571 chr14:90743983 NA 0.53 6.83 0.35 4.02e-11 Longevity; LUSC cis rs12579753 1.000 rs7306395 chr12:82175867 A/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.04 -0.31 4.21e-9 Resting heart rate; LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg08736216 chr1:53307985 ZYG11A -0.3 -6.15 -0.32 2.18e-9 Monocyte count; LUSC cis rs2996428 0.667 rs2368534 chr1:3740640 C/T cg22529645 chr1:3704559 LRRC47 0.37 6.23 0.32 1.44e-9 Red cell distribution width; LUSC cis rs2762353 0.935 rs1165209 chr6:25801319 G/A cg03517284 chr6:25882590 NA -0.43 -7.73 -0.39 1.24e-13 Blood metabolite levels; LUSC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg14829155 chr15:31115871 NA 0.7 10.75 0.51 2.49e-23 Huntington's disease progression; LUSC cis rs929354 0.742 rs2107863 chr7:156963731 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg16680214 chr1:154839983 KCNN3 -0.55 -10.2 -0.49 1.94e-21 Prostate cancer; LUSC cis rs72792276 1.000 rs56657382 chr5:127387338 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 7.42 0.38 9.76e-13 Red cell distribution width; LUSC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg18876405 chr7:65276391 NA -0.55 -8.63 -0.43 2.54e-16 Aortic root size; LUSC cis rs45535039 0.506 rs2511856 chr11:119144148 A/C cg22259797 chr11:118986860 C2CD2L 0.33 6.03 0.31 4.3e-9 Plateletcrit; LUSC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.85 0.3 1.2e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs427941 0.632 rs201471 chr7:101744145 T/G cg06246474 chr7:101738831 CUX1 0.39 6.42 0.33 4.68e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs1372520 0.567 rs2619349 chr4:90746646 G/T cg01966878 chr4:90757139 SNCA -0.42 -5.96 -0.31 6.24e-9 Neuroticism; LUSC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg00129232 chr17:37814104 STARD3 -0.55 -8.25 -0.41 3.77e-15 Asthma; LUSC cis rs7584330 0.554 rs7582964 chr2:238385766 C/T cg14458575 chr2:238380390 NA -0.6 -7.76 -0.39 1.05e-13 Prostate cancer; LUSC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg06219351 chr7:158114137 PTPRN2 -0.51 -9.22 -0.45 3.39e-18 Calcium levels; LUSC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg03452623 chr4:187889614 NA -0.91 -19.08 -0.72 2.06e-55 Lobe attachment (rater-scored or self-reported); LUSC cis rs4604732 0.631 rs74154673 chr1:247625629 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs17095355 0.818 rs6584970 chr10:111847820 A/G cg00817464 chr10:111662876 XPNPEP1 -0.54 -5.99 -0.31 5.57e-9 Biliary atresia; LUSC cis rs7089973 0.604 rs11196936 chr10:116588630 C/T cg25233709 chr10:116636983 FAM160B1 0.37 6.59 0.34 1.69e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs34172651 0.917 rs12599173 chr16:24823619 T/C cg06028605 chr16:24865363 SLC5A11 0.44 7.97 0.4 2.6e-14 Intelligence (multi-trait analysis); LUSC trans rs877282 0.786 rs10904558 chr10:797509 C/T cg22713356 chr15:30763199 NA 1.07 15.84 0.65 1.52e-42 Uric acid levels; LUSC cis rs3812762 0.912 rs11042058 chr11:8763815 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.37 -5.91 -0.31 8.63e-9 Hypospadias; LUSC cis rs877282 1.000 rs10904552 chr10:774326 A/G cg17470449 chr10:769945 NA 0.51 7.23 0.37 3.28e-12 Uric acid levels; LUSC cis rs193541 0.632 rs6595413 chr5:122156949 G/A cg19077854 chr5:122220652 SNX24 0.38 7.9 0.4 4.18e-14 Glucose homeostasis traits; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg27170947 chr2:26402098 FAM59B 0.71 11.01 0.52 2.92e-24 Gut microbiome composition (summer); LUSC cis rs2288073 0.801 rs2384008 chr2:24373150 A/G cg06627628 chr2:24431161 ITSN2 -0.68 -9.3 -0.45 1.85e-18 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs877282 0.945 rs10904550 chr10:774177 C/T cg17470449 chr10:769945 NA 0.51 7.3 0.37 2.06e-12 Uric acid levels; LUSC trans rs747782 0.640 rs11039603 chr11:48256786 G/A cg03929089 chr4:120376271 NA 0.71 6.03 0.31 4.35e-9 Intraocular pressure; LUSC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg20503657 chr10:835505 NA 1.0 13.12 0.58 5.24e-32 Eosinophil percentage of granulocytes; LUSC cis rs7107174 1.000 rs1893448 chr11:77969180 G/A cg02023728 chr11:77925099 USP35 0.47 7.12 0.36 6.7e-12 Testicular germ cell tumor; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18090447 chr1:165797377 UCK2 0.4 6.48 0.33 3.29e-10 Asthma; LUSC cis rs2742234 0.541 rs10793426 chr10:43745280 G/A cg02780029 chr10:43622663 RET 0.35 5.72 0.3 2.4e-8 Hirschsprung disease; LUSC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.67 0.39 1.92e-13 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg23630131 chr7:65973040 NA 0.2 5.74 0.3 2.1e-8 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15226532 chr19:44506876 ZNF230 -0.44 -6.58 -0.34 1.87e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2270927 0.510 rs10942765 chr5:75591324 G/A cg13563193 chr19:33072644 PDCD5 0.78 6.16 0.32 2.05e-9 Mean corpuscular volume; LUSC cis rs9300255 0.739 rs11057210 chr12:123733799 A/G cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.88 -0.31 9.74e-9 Neutrophil percentage of white cells; LUSC cis rs1018697 0.966 rs11191396 chr10:104552865 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.46 0.33 3.65e-10 Colorectal adenoma (advanced); LUSC cis rs9902453 0.838 rs7217638 chr17:28336772 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.79 -0.43 8.23e-17 Coffee consumption (cups per day); LUSC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg05347473 chr6:146136440 FBXO30 0.56 9.49 0.46 4.63e-19 Lobe attachment (rater-scored or self-reported); LUSC trans rs1941687 0.673 rs4427879 chr18:31404751 A/G cg27147174 chr7:100797783 AP1S1 -0.43 -6.56 -0.34 1.99e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs921968 0.613 rs556497 chr2:219446477 G/A cg02176678 chr2:219576539 TTLL4 0.64 11.82 0.54 3.7e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs9308433 0.529 rs11120298 chr1:214500620 A/G cg06198575 chr1:214491504 SMYD2 0.45 6.94 0.36 2.02e-11 IgG glycosylation; LUSC trans rs11039798 0.698 rs6485805 chr11:48101723 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.33 0.33 7.86e-10 Axial length; LUSC cis rs7246657 0.765 rs7247259 chr19:37851090 T/C cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs1775715 0.707 rs2808079 chr10:32167385 C/T cg26784012 chr10:32216390 ARHGAP12 0.44 7.45 0.38 8.2e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7107174 0.688 rs2063725 chr11:78133452 T/G cg27205649 chr11:78285834 NARS2 -0.5 -5.87 -0.31 1.03e-8 Testicular germ cell tumor; LUSC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg12311346 chr5:56204834 C5orf35 0.85 13.67 0.6 4.36e-34 Initial pursuit acceleration; LUSC cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -8.05 -0.4 1.48e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9487051 0.766 rs351748 chr6:109532296 C/T cg12927641 chr6:109611667 NA 0.35 5.74 0.3 2.09e-8 Reticulocyte fraction of red cells; LUSC cis rs77633900 0.614 rs280008 chr15:77011815 T/C cg21673338 chr15:77095150 SCAPER -0.82 -8.05 -0.4 1.48e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg06582575 chr6:163149167 PACRG;PARK2 1.1 15.84 0.66 1.47e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7572644 0.699 rs898032 chr2:28202936 C/G cg27432699 chr2:27873401 GPN1 -0.51 -6.9 -0.35 2.65e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg00546932 chr16:1947055 NA 0.37 5.68 0.3 2.97e-8 Glomerular filtration rate in chronic kidney disease; LUSC trans rs11700980 1.000 rs77484014 chr21:30125709 G/A cg05609335 chr17:75789393 NA 0.41 6.21 0.32 1.59e-9 QRS complex (12-leadsum); LUSC trans rs4650994 0.544 rs11579513 chr1:178496092 T/C cg05059571 chr16:84539110 KIAA1609 -0.47 -9.14 -0.45 6.17e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg12463550 chr7:65579703 CRCP -0.49 -7.02 -0.36 1.23e-11 Aortic root size; LUSC cis rs9905704 0.647 rs33922512 chr17:57114148 C/G cg12560992 chr17:57184187 TRIM37 -0.64 -10.6 -0.5 7.99e-23 Testicular germ cell tumor; LUSC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg06740227 chr12:86229804 RASSF9 0.45 7.16 0.36 5.25e-12 Major depressive disorder; LUSC cis rs4595586 0.545 rs1319791 chr12:39372486 G/T cg13010199 chr12:38710504 ALG10B 0.44 6.17 0.32 1.92e-9 Morning vs. evening chronotype; LUSC trans rs2416257 0.673 rs17625012 chr5:110462919 A/T cg17356964 chr6:106582638 NA 0.7 6.36 0.33 6.51e-10 Eosinophil counts; LUSC cis rs4474465 0.688 rs10501429 chr11:78279790 T/G cg27205649 chr11:78285834 NARS2 0.54 6.6 0.34 1.63e-10 Alzheimer's disease (survival time); LUSC cis rs62400317 0.859 rs72858511 chr6:45218119 A/G cg18551225 chr6:44695536 NA -0.46 -7.58 -0.38 3.53e-13 Total body bone mineral density; LUSC trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg15556689 chr8:8085844 FLJ10661 -0.52 -7.73 -0.39 1.27e-13 Monocyte count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25386820 chr18:21242428 ANKRD29 0.43 6.0 0.31 5.25e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg11645453 chr3:52864694 ITIH4 0.35 8.1 0.41 1.07e-14 Bipolar disorder; LUSC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg07701084 chr6:150067640 NUP43 0.54 8.23 0.41 4.16e-15 Lung cancer; LUSC cis rs9487051 0.735 rs351756 chr6:109538773 A/G cg01475377 chr6:109611718 NA 0.35 6.03 0.31 4.42e-9 Reticulocyte fraction of red cells; LUSC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC cis rs965604 1.000 rs12903295 chr15:78778972 A/G cg18825076 chr15:78729989 IREB2 -0.43 -6.93 -0.35 2.12e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs3857536 0.813 rs9354405 chr6:66948575 G/T cg07460842 chr6:66804631 NA -0.45 -6.37 -0.33 6.42e-10 Blood trace element (Cu levels); LUSC cis rs9788682 0.668 rs2036529 chr15:78726272 A/T cg06917634 chr15:78832804 PSMA4 0.5 6.12 0.32 2.55e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7127900 0.583 rs11043147 chr11:2234169 C/G cg25635251 chr11:2234043 NA 0.87 16.25 0.66 3.75e-44 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); LUSC cis rs4969178 0.965 rs4969186 chr17:76398404 C/G cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 9.01e-21 HDL cholesterol levels; LUSC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg24733560 chr20:60626293 TAF4 0.36 5.93 0.31 7.49e-9 Body mass index; LUSC cis rs6066835 1.000 rs6066828 chr20:47344233 C/T cg18078177 chr20:47281410 PREX1 0.69 5.98 0.31 5.66e-9 Multiple myeloma; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg25767906 chr1:53392781 SCP2 -0.62 -12.25 -0.56 9.28e-29 Monocyte count; LUSC cis rs4595586 0.545 rs61939643 chr12:39378460 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg22875332 chr1:76189707 ACADM 0.78 13.23 0.59 1.98e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg11663144 chr21:46675770 NA -0.43 -7.55 -0.38 4.24e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7191439 0.858 rs4238685 chr16:88775220 T/C cg27087555 chr16:88793112 FAM38A -1.42 -12.34 -0.56 4.47e-29 Plateletcrit; LUSC cis rs9549367 0.789 rs9549715 chr13:113908240 G/C cg00898013 chr13:113819073 PROZ -0.56 -8.11 -0.41 1.01e-14 Platelet distribution width; LUSC cis rs13385 0.769 rs4913075 chr5:139613571 A/G cg26211634 chr5:139558579 C5orf32 0.45 6.7 0.34 9.06e-11 Atrial fibrillation; LUSC cis rs2857891 0.817 rs2857885 chr11:6967187 G/A cg04053776 chr11:6947353 ZNF215 0.43 6.16 0.32 2.05e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7903847 0.642 rs7903562 chr10:99154782 T/C cg08345082 chr10:99160200 RRP12 -0.36 -7.41 -0.38 1.02e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.36 0.33 6.49e-10 Menopause (age at onset); LUSC cis rs9303401 0.659 rs9303399 chr17:56672309 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.39 0.59 5.2e-33 Cognitive test performance; LUSC cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.53e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2197308 0.740 rs1842595 chr12:37906223 G/A cg06521331 chr12:34319734 NA 0.4 6.32 0.33 8.45e-10 Morning vs. evening chronotype; LUSC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg25204440 chr1:209979598 IRF6 0.5 5.72 0.3 2.36e-8 Cleft lip with or without cleft palate; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg15112475 chr7:1198522 ZFAND2A -0.28 -5.64 -0.3 3.55e-8 Longevity;Endometriosis; LUSC trans rs710987 0.760 rs710995 chr5:3515519 A/G cg27629735 chr1:3556483 WDR8 -0.37 -6.18 -0.32 1.9e-9 Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis; LUSC cis rs4843185 0.637 rs4143866 chr16:85716366 A/G cg05245094 chr16:85669572 KIAA0182 0.43 6.14 0.32 2.41e-9 Platelet distribution width; LUSC trans rs11098499 0.909 rs9759478 chr4:120367998 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.23 0.41 4.34e-15 Corneal astigmatism; LUSC trans rs11696501 0.688 rs714595 chr20:44330591 G/A cg03272292 chr12:48577362 C12orf68 0.49 6.02 0.31 4.69e-9 Brain structure; LUSC cis rs3809566 1.000 rs4775612 chr15:63332157 T/C cg00520135 chr15:63333846 TPM1 -0.34 -6.78 -0.35 5.42e-11 Platelet count; LUSC trans rs61931739 0.817 rs188588 chr12:34215277 G/A cg26384229 chr12:38710491 ALG10B 0.54 8.6 0.43 3.09e-16 Morning vs. evening chronotype; LUSC cis rs7572644 0.699 rs2016616 chr2:28134037 A/G cg27432699 chr2:27873401 GPN1 -0.52 -6.95 -0.36 1.91e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs34734847 0.787 rs695949 chr12:121149736 A/G cg21892295 chr12:121157589 UNC119B -0.45 -8.06 -0.4 1.35e-14 Mean corpuscular volume; LUSC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Vitiligo; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08345776 chr10:71993218 PPA1 -0.37 -6.03 -0.31 4.42e-9 Electrocardiographic conduction measures; LUSC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg17264618 chr3:40429014 ENTPD3 0.35 7.19 0.37 4.15e-12 Renal cell carcinoma; LUSC cis rs17155006 0.711 rs377007 chr7:107750446 T/A cg05962710 chr7:107745446 LAMB4 -0.36 -6.29 -0.33 9.97e-10 Pneumococcal bacteremia; LUSC cis rs7495211 0.529 rs11247364 chr15:98623984 A/T cg25404375 chr15:99409942 IGF1R -0.39 -5.87 -0.31 1.07e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg04362960 chr10:104952993 NT5C2 0.49 6.24 0.32 1.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs4729127 1.000 rs12669501 chr7:93995008 C/T cg20086523 chr13:52378287 DHRS12 0.57 6.09 0.32 3.07e-9 Intelligence; LUSC cis rs2932538 0.922 rs6671645 chr1:113129128 A/G cg22162597 chr1:113214053 CAPZA1 0.53 7.69 0.39 1.66e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs733592 0.931 rs765260 chr12:48431936 C/T cg24011408 chr12:48396354 COL2A1 -0.46 -7.59 -0.38 3.32e-13 Plateletcrit; LUSC cis rs10193935 0.892 rs12622152 chr2:42482929 C/A cg27598129 chr2:42591480 NA -0.61 -8.22 -0.41 4.7e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9807989 0.507 rs4851571 chr2:103019000 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.17e-12 Asthma; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg25036284 chr2:26402008 FAM59B -0.69 -10.17 -0.49 2.34e-21 Gut microbiome composition (summer); LUSC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.61 0.62 1.05e-37 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9612 1.000 rs346526 chr19:44259565 A/G cg08581076 chr19:44259116 C19orf61 0.53 6.66 0.34 1.1e-10 Exhaled nitric oxide output; LUSC cis rs6598955 0.671 rs17162105 chr1:26591255 A/G cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs977987 0.843 rs4887820 chr16:75397287 C/T cg03315344 chr16:75512273 CHST6 0.48 9.18 0.45 4.78e-18 Dupuytren's disease; LUSC cis rs55871839 0.708 rs1448541 chr8:59812938 G/A cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg07157834 chr1:205819609 PM20D1 0.89 16.47 0.67 5.01e-45 Menarche (age at onset); LUSC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg02772935 chr3:125709198 NA -0.48 -5.78 -0.3 1.7e-8 Blood pressure (smoking interaction); LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.29 0.67 2.45e-44 Gut microbiome composition (summer); LUSC cis rs12618769 0.597 rs4851140 chr2:99079339 T/C cg10123293 chr2:99228465 UNC50 0.46 7.74 0.39 1.21e-13 Bipolar disorder; LUSC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg10169327 chr19:45448959 APOC2 0.3 6.21 0.32 1.59e-9 Blood protein levels; LUSC cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs911555 0.692 rs7146215 chr14:103915908 A/G cg12935359 chr14:103987150 CKB 0.66 10.73 0.51 2.73e-23 Intelligence (multi-trait analysis); LUSC cis rs17270561 0.636 rs7453371 chr6:25719256 A/G cg17691542 chr6:26056736 HIST1H1C 0.56 7.84 0.39 6.1e-14 Iron status biomarkers; LUSC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg11062466 chr8:58055876 NA 0.67 8.14 0.41 7.83e-15 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg19717773 chr7:2847554 GNA12 -0.39 -6.16 -0.32 2.12e-9 Height; LUSC cis rs4919694 0.572 rs12240508 chr10:104939232 G/A cg05855489 chr10:104503620 C10orf26 0.55 6.36 0.33 6.81e-10 Arsenic metabolism; LUSC cis rs6582630 0.516 rs12814528 chr12:38296111 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.97 -0.36 1.72e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs11122272 0.735 rs2474634 chr1:231487017 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.8 0.47 4.44e-20 Hemoglobin concentration; LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg22535103 chr8:58192502 C8orf71 -0.79 -8.22 -0.41 4.44e-15 Developmental language disorder (linguistic errors); LUSC cis rs9811920 0.809 rs1387647 chr3:99826942 T/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 6.39 0.33 5.5e-10 Axial length; LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg23978390 chr7:1156363 C7orf50 0.46 6.6 0.34 1.6e-10 Longevity;Endometriosis; LUSC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.8 0.65 2.17e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs11148252 0.634 rs4941727 chr13:52721067 A/G cg18335740 chr13:41363409 SLC25A15 -0.45 -6.96 -0.36 1.77e-11 Lewy body disease; LUSC cis rs7647973 0.826 rs9834535 chr3:49378797 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.43 6.44 0.33 4.24e-10 Menarche (age at onset); LUSC cis rs921968 0.565 rs3770220 chr2:219619550 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs8177253 0.555 rs4481157 chr3:133464684 G/A cg01448562 chr3:133502909 NA -0.47 -7.4 -0.38 1.15e-12 Iron status biomarkers; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.12 0.41 9.04e-15 Prudent dietary pattern; LUSC cis rs7202877 0.706 rs247423 chr16:75456631 C/A cg03315344 chr16:75512273 CHST6 -0.42 -5.99 -0.31 5.52e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs477692 1.000 rs530466 chr10:131427717 A/G cg05714579 chr10:131428358 MGMT 0.52 7.81 0.39 7.51e-14 Response to temozolomide; LUSC cis rs427394 0.664 rs274697 chr5:6731477 A/C cg25011763 chr5:6727354 POLS -0.36 -6.18 -0.32 1.83e-9 Menopause (age at onset); LUSC cis rs3768617 0.811 rs12563494 chr1:183039698 G/A ch.1.3577855R chr1:183094577 LAMC1 0.6 8.64 0.43 2.29e-16 Fuchs's corneal dystrophy; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg10802521 chr3:52805072 NEK4 -0.57 -9.09 -0.45 8.74e-18 Bipolar disorder; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg25703541 chr22:24373054 LOC391322 -1.0 -19.87 -0.74 1.49e-58 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9905704 0.918 rs302880 chr17:56761411 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.79 0.39 8.77e-14 Testicular germ cell tumor; LUSC cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg24130564 chr14:104152367 KLC1 0.69 10.87 0.51 8.84e-24 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.806 rs2293293 chr3:134322742 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.79 -12.52 -0.57 9.26e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3755132 0.929 rs976233 chr2:15774115 C/T cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09376238 chr14:96830058 ATG2B -0.4 -6.02 -0.31 4.61e-9 Electrocardiographic conduction measures; LUSC trans rs12310956 0.515 rs1872745 chr12:33985987 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.83 0.51 1.22e-23 Morning vs. evening chronotype; LUSC cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.94 -0.31 7.02e-9 Body mass index; LUSC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.11 -0.41 9.73e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11890956 chr21:40555474 PSMG1 1.03 20.73 0.75 5.92e-62 Cognitive function; LUSC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg13319975 chr6:146136371 FBXO30 0.71 10.36 0.49 5.35e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs4794106 0.792 rs11365 chr17:48211533 T/G cg13127421 chr17:48202128 SAMD14 -0.55 -9.02 -0.44 1.47e-17 Temporomandibular joint disorder; LUSC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs9325144 0.600 rs12227663 chr12:38734922 C/T cg13010199 chr12:38710504 ALG10B -0.48 -7.35 -0.37 1.5e-12 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.56 0.38 3.83e-13 Prudent dietary pattern; LUSC cis rs55665837 1.000 rs11023216 chr11:14437153 G/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.54 -0.38 4.53e-13 Vitamin D levels; LUSC cis rs7241530 0.662 rs6506755 chr18:75905002 A/G cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs6840360 0.550 rs6816471 chr4:152494869 A/G cg22705602 chr4:152727874 NA -0.33 -6.67 -0.34 1.08e-10 Intelligence (multi-trait analysis); LUSC cis rs62481355 0.680 rs2106177 chr7:127072695 T/G cg25922125 chr7:127225783 GCC1 -0.42 -5.74 -0.3 2.16e-8 Type 2 diabetes; LUSC cis rs10857712 0.950 rs10857711 chr10:135224059 G/A cg01444801 chr10:135216882 MTG1 -0.49 -6.49 -0.33 3.08e-10 Systemic lupus erythematosus; LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.45 -5.92 -0.31 8.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -7.44 -0.38 8.73e-13 Menarche (age at onset); LUSC cis rs6570726 0.967 rs1396648 chr6:145785248 C/A cg05347473 chr6:146136440 FBXO30 -0.38 -6.3 -0.33 9.2e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs34172651 0.917 rs1075987 chr16:24794957 G/A cg06028605 chr16:24865363 SLC5A11 0.45 7.95 0.4 2.96e-14 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.803 rs12701432 chr7:1052453 C/T cg06145435 chr7:1022769 CYP2W1 0.34 5.8 0.3 1.52e-8 Bronchopulmonary dysplasia; LUSC trans rs57046232 0.552 rs6038449 chr20:6337980 C/T cg17788362 chr6:86352627 SYNCRIP 0.44 6.21 0.32 1.61e-9 Colorectal cancer; LUSC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg25456477 chr12:86230367 RASSF9 0.35 6.25 0.32 1.24e-9 Major depressive disorder; LUSC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.54 -10.18 -0.49 2.29e-21 Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10581632 chr12:56360715 CDK2;SILV 0.41 6.12 0.32 2.63e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs79387448 0.638 rs76255660 chr2:103091028 T/C cg09003973 chr2:102972529 NA 0.98 9.6 0.47 1.9e-19 Gut microbiota (bacterial taxa); LUSC cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.36 -5.84 -0.3 1.25e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504073 0.669 rs341802 chr8:50039313 C/T cg00325661 chr8:49890786 NA 0.59 9.47 0.46 5.11e-19 Blood metabolite ratios; LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg26338869 chr17:61819248 STRADA 0.42 5.96 0.31 6.57e-9 Prudent dietary pattern; LUSC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg27398817 chr8:82754497 SNX16 -0.46 -6.18 -0.32 1.82e-9 Diastolic blood pressure; LUSC cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg03213289 chr20:61660250 NA 0.66 13.48 0.59 2.21e-33 Prostate cancer (SNP x SNP interaction); LUSC cis rs9296092 0.517 rs56206922 chr6:33522567 C/T cg13560919 chr6:33536144 NA -0.82 -15.86 -0.66 1.26e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg17971929 chr21:40555470 PSMG1 0.8 14.11 0.61 8.94e-36 Cognitive function; LUSC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg17971929 chr21:40555470 PSMG1 -0.51 -7.69 -0.39 1.67e-13 Menarche (age at onset); LUSC cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.74e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7084921 0.608 rs2862950 chr10:101844785 A/G cg02250046 chr10:101825185 CPN1 -0.33 -5.97 -0.31 6.19e-9 Bone mineral density; LUSC cis rs9296092 0.538 rs78061112 chr6:33526587 T/G cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7100689 0.646 rs2486302 chr10:82076600 G/A cg00277334 chr10:82204260 NA -0.58 -8.73 -0.43 1.25e-16 Post bronchodilator FEV1; LUSC cis rs870825 0.860 rs72703527 chr4:185605997 C/A cg04058563 chr4:185651563 MLF1IP 0.77 10.15 0.49 2.77e-21 Blood protein levels; LUSC cis rs4363385 0.818 rs407448 chr1:153007504 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.87 -0.31 1.04e-8 Inflammatory skin disease; LUSC cis rs9467773 1.000 rs2393670 chr6:26535541 A/G cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.86e-18 Intelligence (multi-trait analysis); LUSC cis rs597583 0.806 rs11603340 chr11:117396527 C/G cg27161313 chr11:117392002 DSCAML1 -0.43 -7.19 -0.37 4.33e-12 Putamen volume; LUSC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg09034736 chr1:150693464 HORMAD1 0.45 6.46 0.33 3.6e-10 Melanoma; LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg18404041 chr3:52824283 ITIH1 -0.61 -11.74 -0.54 7.31e-27 Bipolar disorder; LUSC cis rs10927875 0.757 rs4661679 chr1:16321010 C/T cg21385522 chr1:16154831 NA 0.51 7.87 0.4 4.91e-14 Dilated cardiomyopathy; LUSC cis rs11051970 0.879 rs2171373 chr12:32575777 C/T cg24626660 chr12:32551988 NA 0.33 5.7 0.3 2.69e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2625529 0.652 rs2957745 chr15:72288077 T/C cg16672083 chr15:72433130 SENP8 0.48 8.0 0.4 2.08e-14 Red blood cell count; LUSC cis rs721399 0.583 rs4646267 chr8:18247913 A/G cg18736775 chr8:18248649 NAT2 -0.57 -6.55 -0.34 2.12e-10 Blood metabolite levels; LUSC cis rs9549367 0.789 rs9549716 chr13:113908478 G/A cg00898013 chr13:113819073 PROZ -0.53 -7.85 -0.39 5.78e-14 Platelet distribution width; LUSC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg13770153 chr20:60521292 NA -1.04 -16.15 -0.66 9.53e-44 Obesity-related traits; LUSC cis rs8014204 0.905 rs8014289 chr14:75377352 A/G cg06637938 chr14:75390232 RPS6KL1 -0.69 -12.23 -0.56 1.12e-28 Caffeine consumption; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.04e-26 Prudent dietary pattern; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg00684032 chr4:1343700 KIAA1530 -0.37 -6.51 -0.34 2.81e-10 Obesity-related traits; LUSC cis rs9443645 0.527 rs9359360 chr6:79702796 C/T cg05283184 chr6:79620031 NA -0.46 -8.62 -0.43 2.78e-16 Intelligence (multi-trait analysis); LUSC cis rs6121246 0.697 rs6087716 chr20:30229040 C/T cg13852791 chr20:30311386 BCL2L1 0.84 10.32 0.49 7.33e-22 Mean corpuscular hemoglobin; LUSC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg26818010 chr10:134567672 INPP5A -0.84 -10.6 -0.5 7.9e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs877282 0.891 rs34383514 chr10:800181 T/C cg22713356 chr15:30763199 NA 1.14 15.73 0.65 3.98e-42 Uric acid levels; LUSC cis rs5769765 0.773 rs138834 chr22:50180497 A/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.69 -8.69 -0.43 1.6e-16 Schizophrenia; LUSC cis rs8044995 0.563 rs56331745 chr16:68368770 G/T cg05110241 chr16:68378359 PRMT7 -0.76 -8.6 -0.43 3.22e-16 Schizophrenia; LUSC cis rs11190604 1.000 rs11190589 chr10:102275471 A/G cg16342193 chr10:102329863 NA -0.36 -6.64 -0.34 1.3e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg26408565 chr15:76604113 ETFA 0.48 7.81 0.39 7.41e-14 Blood metabolite levels; LUSC cis rs7503807 0.967 rs4889867 chr17:78593058 C/T cg09596252 chr17:78655493 RPTOR 0.43 7.44 0.38 8.47e-13 Obesity; LUSC cis rs4343996 0.727 rs4499989 chr7:3371291 T/G cg21248987 chr7:3385318 SDK1 -0.36 -6.15 -0.32 2.17e-9 Motion sickness; LUSC cis rs12474201 0.963 rs11676737 chr2:46929873 T/C cg06386533 chr2:46925753 SOCS5 0.77 11.77 0.54 5.58e-27 Height; LUSC cis rs7520050 0.807 rs6671802 chr1:46124663 A/G cg24296786 chr1:45957014 TESK2 -0.41 -5.81 -0.3 1.47e-8 Red blood cell count;Reticulocyte count; LUSC cis rs941873 0.805 rs876678 chr10:81111036 G/T cg09469691 chr10:81107165 PPIF 0.59 8.85 0.44 5.28e-17 Height; LUSC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg07636037 chr3:49044803 WDR6 1.05 18.92 0.72 9.37e-55 Parkinson's disease; LUSC cis rs1448094 0.967 rs7978132 chr12:86323484 T/C cg00310523 chr12:86230176 RASSF9 0.39 6.98 0.36 1.58e-11 Major depressive disorder; LUSC cis rs9311676 0.656 rs66793022 chr3:58391565 C/T cg13750441 chr3:58318267 PXK 0.35 6.77 0.35 5.89e-11 Systemic lupus erythematosus; LUSC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg08677398 chr8:58056175 NA 0.54 6.56 0.34 2.1e-10 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg21573476 chr21:45109991 RRP1B -0.36 -5.68 -0.3 2.96e-8 Mean corpuscular volume; LUSC cis rs11209185 0.545 rs11209184 chr1:68421069 C/T cg22082780 chr1:68452167 NA 0.38 6.52 0.34 2.67e-10 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg06022373 chr22:39101656 GTPBP1 0.83 13.96 0.61 3.27e-35 Menopause (age at onset); LUSC cis rs6736093 1.000 rs79688911 chr2:112657907 C/T cg12686935 chr2:112915763 FBLN7 -0.39 -6.05 -0.31 3.78e-9 Coronary artery disease; LUSC cis rs8056893 0.714 rs1530643 chr16:68396092 T/C cg02226672 chr16:68398533 SMPD3 0.33 5.93 0.31 7.59e-9 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs73198271 0.920 rs11781542 chr8:8617181 G/T cg01851573 chr8:8652454 MFHAS1 0.56 8.51 0.42 6.09e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10761482 0.813 rs3808942 chr10:62150848 C/T cg18175470 chr10:62150864 ANK3 -0.56 -8.45 -0.42 9.38e-16 Schizophrenia; LUSC cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.61 -0.34 1.48e-10 Arsenic metabolism; LUSC cis rs16910800 1.000 rs7114414 chr11:23201509 A/G cg20040320 chr11:23191996 NA -0.44 -6.35 -0.33 6.87e-10 Cancer; LUSC cis rs4906332 0.966 rs7401563 chr14:103964425 G/A cg04998671 chr14:104000505 TRMT61A -0.45 -7.12 -0.36 6.63e-12 Coronary artery disease; LUSC cis rs2404602 0.716 rs2404736 chr15:76875943 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.13 -0.36 6.09e-12 Blood metabolite levels; LUSC cis rs963731 0.579 rs1454226 chr2:39246862 A/G cg04010122 chr2:39346883 SOS1 -0.82 -5.74 -0.3 2.11e-8 Corticobasal degeneration; LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs3733585 0.699 rs10001964 chr4:9959275 C/T cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10751667 0.961 rs7480178 chr11:927108 T/C cg06064525 chr11:970664 AP2A2 -0.36 -7.17 -0.37 4.88e-12 Alzheimer's disease (late onset); LUSC cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs9393777 0.623 rs3734544 chr6:26468660 G/A cg05738196 chr6:26577821 NA -0.55 -5.96 -0.31 6.48e-9 Intelligence (multi-trait analysis); LUSC cis rs3857536 0.813 rs9453639 chr6:66933538 C/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs225245 0.755 rs8078905 chr17:34009029 T/C cg05299278 chr17:33885742 SLFN14 0.3 6.46 0.33 3.8e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.44 0.53 8.79e-26 Prudent dietary pattern; LUSC trans rs459571 0.883 rs2520096 chr9:136919416 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.72 -12.14 -0.55 2.36e-28 Platelet distribution width; LUSC cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs10876993 0.928 rs1689594 chr12:58057156 T/C cg18357645 chr12:58087776 OS9 0.55 8.34 0.42 1.95e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs372883 0.530 rs2832302 chr21:30749793 G/T cg24692254 chr21:30365293 RNF160 -0.68 -11.01 -0.52 3.01e-24 Pancreatic cancer; LUSC cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg00071950 chr4:10020882 SLC2A9 0.66 10.98 0.51 3.84e-24 Bone mineral density; LUSC cis rs782590 0.967 rs11125579 chr2:55739804 T/C cg18811423 chr2:55921094 PNPT1 0.75 12.82 0.57 7.34e-31 Metabolic syndrome; LUSC cis rs868036 0.718 rs4776984 chr15:68118194 A/C cg08079166 chr15:68083412 MAP2K5 0.39 6.96 0.36 1.75e-11 Restless legs syndrome; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg10862848 chr6:42927986 GNMT -0.29 -6.83 -0.35 4.02e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg05025164 chr4:1340916 KIAA1530 0.48 7.58 0.38 3.53e-13 Obesity-related traits; LUSC cis rs1957429 0.520 rs66511472 chr14:65330330 C/A cg23373153 chr14:65346875 NA -0.85 -7.9 -0.4 4.11e-14 Pediatric areal bone mineral density (radius); LUSC cis rs2806561 0.765 rs2806565 chr1:23507068 A/G cg12483005 chr1:23474871 LUZP1 0.41 6.38 0.33 6.03e-10 Height; LUSC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg06212747 chr3:49208901 KLHDC8B 0.45 6.13 0.32 2.45e-9 Parkinson's disease; LUSC cis rs3020736 0.500 rs7292241 chr22:42492063 G/A cg15557168 chr22:42548783 NA 0.45 6.76 0.35 6.2e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg21361702 chr7:150065534 REPIN1 0.59 8.39 0.42 1.38e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs3812831 0.695 rs6560935 chr13:114945867 G/A cg15896084 chr13:114927664 NA 0.41 7.4 0.38 1.11e-12 Schizophrenia; LUSC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 7.78 0.39 9.16e-14 Schizophrenia; LUSC cis rs8042849 1 rs8042849 chr15:78817929 C/T cg06917634 chr15:78832804 PSMA4 0.45 6.33 0.33 7.88e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Parental lifespan;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg02228329 chr11:64053129 BAD;GPR137 0.53 7.78 0.39 9.38e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs208520 0.690 rs12192851 chr6:66705862 G/C cg07460842 chr6:66804631 NA 1.08 16.95 0.68 6.24e-47 Exhaled nitric oxide output; LUSC cis rs977987 0.806 rs34996006 chr16:75479434 A/G cg04384234 chr16:75411784 CFDP1 -0.42 -6.96 -0.36 1.8e-11 Dupuytren's disease; LUSC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg07959070 chr22:50026188 C22orf34 -0.35 -6.99 -0.36 1.55e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg23172400 chr8:95962367 TP53INP1 -0.41 -8.5 -0.42 6.24e-16 Type 2 diabetes; LUSC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg16060761 chr17:80687452 NA -0.41 -6.61 -0.34 1.49e-10 Breast cancer; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg03188948 chr7:1209495 NA 0.62 6.56 0.34 2.03e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg19812747 chr11:111475976 SIK2 -0.55 -8.17 -0.41 6.25e-15 Primary sclerosing cholangitis; LUSC cis rs7532866 0.885 rs7520137 chr1:26731035 T/G cg17456097 chr1:26900765 RPS6KA1 -0.42 -6.11 -0.32 2.85e-9 Height; LUSC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.92 -13.21 -0.59 2.33e-32 Chronic sinus infection; LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg11766577 chr21:47581405 C21orf56 -0.54 -8.5 -0.42 6.6e-16 Testicular germ cell tumor; LUSC cis rs8062405 0.755 rs17640009 chr16:28595700 A/G cg16576597 chr16:28551801 NUPR1 0.3 6.19 0.32 1.81e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11890956 chr21:40555474 PSMG1 -0.73 -10.86 -0.51 9.87e-24 Menarche (age at onset); LUSC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg00677455 chr12:58241039 CTDSP2 0.61 8.47 0.42 7.68e-16 Multiple sclerosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02533120 chr21:33031840 SOD1 -0.54 -6.46 -0.33 3.71e-10 Bipolar disorder and schizophrenia; LUSC cis rs1801251 1.000 rs11555646 chr2:233599904 A/C cg08000102 chr2:233561755 GIGYF2 0.7 11.65 0.54 1.45e-26 Coronary artery disease; LUSC cis rs7553864 0.667 rs7512650 chr1:87609076 T/C cg17420885 chr1:87600446 LOC339524 -0.49 -6.77 -0.35 5.83e-11 Smoking behavior; LUSC trans rs11098499 0.863 rs1480940 chr4:120457682 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.73 0.35 7.27e-11 Corneal astigmatism; LUSC cis rs870825 0.520 rs10022842 chr4:185649459 A/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC trans rs1275468 0.689 rs1795382 chr12:75979893 A/G cg04012681 chr10:1511277 ADARB2 0.37 5.98 0.31 5.77e-9 Polycystic ovary syndrome; LUSC cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg12219531 chr12:120966889 COQ5 0.57 7.73 0.39 1.29e-13 High light scatter reticulocyte count; LUSC cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14240646 chr10:27532245 ACBD5 -0.74 -8.23 -0.41 4.36e-15 Breast cancer; LUSC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.03 -0.31 4.44e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs8060686 0.641 rs1125333 chr16:68227566 C/A cg04539111 chr16:67997858 SLC12A4 -0.43 -5.68 -0.3 2.99e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7172677 0.696 rs56262544 chr15:75379471 A/G cg14664628 chr15:75095509 CSK 0.51 6.53 0.34 2.38e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg24503407 chr1:205819492 PM20D1 -0.44 -6.54 -0.34 2.26e-10 Menarche (age at onset); LUSC cis rs62432291 0.681 rs447637 chr6:159658726 A/G cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G ch.12.124321348F chr12:125755395 NA 0.45 6.04 0.31 4.07e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4729127 1.000 rs17166229 chr7:94017673 A/G cg22713327 chr12:120703336 PXN 0.57 6.0 0.31 5.17e-9 Intelligence; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg18765753 chr7:1198926 ZFAND2A -0.58 -10.91 -0.51 6.49e-24 Longevity;Endometriosis; LUSC trans rs62103177 0.810 rs62096746 chr18:77619556 T/A cg05926928 chr17:57297772 GDPD1 1.43 17.45 0.69 6.4e-49 Opioid sensitivity; LUSC trans rs4843747 0.671 rs28671027 chr16:88116323 G/A cg26811252 chr16:29126840 RRN3P2 0.6 9.64 0.47 1.46e-19 Menopause (age at onset); LUSC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg23172400 chr8:95962367 TP53INP1 -0.39 -8.1 -0.41 1.04e-14 Type 2 diabetes; LUSC cis rs12900413 0.687 rs6496599 chr15:90314582 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.75 -0.3 2.05e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs554111 0.656 rs12567861 chr1:21395133 C/T cg01072550 chr1:21505969 NA 0.37 5.71 0.3 2.51e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs4803468 0.967 rs3786553 chr19:41902746 T/G cg09537434 chr19:41945824 ATP5SL -0.88 -15.08 -0.64 1.52e-39 Height; LUSC cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4642101 0.680 rs7626609 chr3:12806080 A/G cg05775895 chr3:12838266 CAND2 -0.48 -7.68 -0.39 1.75e-13 QRS complex (12-leadsum); LUSC cis rs6594499 0.872 rs1379298 chr5:110435726 T/C cg04022379 chr5:110408740 TSLP 0.43 6.47 0.33 3.54e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2708377 0.860 rs35318883 chr12:11309750 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg03354898 chr7:1950403 MAD1L1 -0.46 -9.57 -0.46 2.45e-19 Bipolar disorder and schizophrenia; LUSC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg27165867 chr14:105738592 BRF1 -0.52 -7.45 -0.38 7.91e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs2439831 0.867 rs4583210 chr15:43660925 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.16 0.58 3.88e-32 Lung cancer in ever smokers; LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.33 -0.37 1.75e-12 Developmental language disorder (linguistic errors); LUSC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg24531977 chr5:56204891 C5orf35 -0.56 -8.16 -0.41 6.79e-15 Coronary artery disease; LUSC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 8.91 0.44 3.34e-17 Total body bone mineral density; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg02951883 chr7:2050386 MAD1L1 -0.44 -7.58 -0.38 3.41e-13 Bipolar disorder and schizophrenia; LUSC cis rs3106136 0.934 rs4693004 chr4:95168456 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.11 -0.32 2.76e-9 Capecitabine sensitivity; LUSC cis rs10876993 0.890 rs115106209 chr12:58059331 G/A cg15848620 chr12:58087721 OS9 -0.55 -7.87 -0.4 4.88e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg08213375 chr14:104286397 PPP1R13B 0.48 8.53 0.42 5.03e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs7771547 0.519 rs4713972 chr6:36371316 C/A cg07856975 chr6:36356162 ETV7 0.44 6.49 0.33 3.08e-10 Platelet distribution width; LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg25767906 chr1:53392781 SCP2 -0.52 -9.52 -0.46 3.62e-19 Monocyte count; LUSC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg05425664 chr17:57184151 TRIM37 -0.55 -8.05 -0.4 1.47e-14 Intelligence (multi-trait analysis); LUSC cis rs9768139 0.634 rs11762383 chr7:158113889 C/T cg24154853 chr7:158122151 PTPRN2 0.44 8.6 0.43 3.06e-16 Calcium levels; LUSC cis rs7089973 0.604 rs1359079 chr10:116582502 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.16 0.45 5.47e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs950169 0.887 rs3860265 chr15:84945185 C/T cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.96 0.58 2.08e-31 Hip circumference adjusted for BMI; LUSC cis rs4727027 0.870 rs1534196 chr7:148790591 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.12 0.32 2.63e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1371867 0.846 rs1692007 chr8:101268343 T/C cg06636551 chr8:101224915 SPAG1 0.38 7.02 0.36 1.23e-11 Atrioventricular conduction; LUSC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg19729930 chr2:74357872 NA 0.88 16.75 0.68 3.82e-46 Gestational age at birth (maternal effect); LUSC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg26597838 chr10:835615 NA 0.99 14.04 0.61 1.7000000000000001e-35 Eosinophil percentage of granulocytes; LUSC trans rs7951105 0.867 rs976908 chr11:39247801 C/T cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg13072238 chr3:49761600 GMPPB 0.37 5.93 0.31 7.36e-9 Body mass index; LUSC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.15 -0.36 5.59e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.8 0.47 4.24e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6598955 0.543 rs60433268 chr1:26548055 A/C cg04990556 chr1:26633338 UBXN11 0.84 11.12 0.52 1.24e-24 Obesity-related traits; LUSC cis rs2439831 1.000 rs2439850 chr15:43784854 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs921968 0.510 rs2577761 chr2:219462500 G/A cg02176678 chr2:219576539 TTLL4 0.75 14.7 0.63 4.6e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg21951975 chr1:209979733 IRF6 0.61 7.89 0.4 4.43e-14 Cleft lip with or without cleft palate; LUSC cis rs7481584 0.624 rs438384 chr11:3045651 A/G cg08508325 chr11:3079039 CARS 0.39 8.3 0.41 2.7e-15 Calcium levels; LUSC cis rs9644630 0.897 rs4921654 chr8:19359974 G/T cg01280390 chr8:19363452 CSGALNACT1 -0.35 -6.59 -0.34 1.69e-10 Oropharynx cancer; LUSC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg03709012 chr19:19516395 GATAD2A 0.74 11.3 0.53 2.7e-25 Tonsillectomy; LUSC cis rs13315871 0.790 rs13066409 chr3:58428444 A/G cg12435725 chr3:58293450 RPP14 -0.7 -6.89 -0.35 2.75e-11 Cholesterol, total; LUSC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg05425664 chr17:57184151 TRIM37 -0.55 -8.11 -0.41 9.42e-15 Intelligence (multi-trait analysis); LUSC cis rs7131987 0.683 rs12366505 chr12:29474110 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.77 -0.35 5.69e-11 QT interval; LUSC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg15445000 chr17:37608096 MED1 -0.4 -6.8 -0.35 4.69e-11 Glomerular filtration rate (creatinine); LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg16405210 chr4:1374714 KIAA1530 0.78 12.42 0.56 2.27e-29 Longevity; LUSC cis rs9640161 0.830 rs1051760 chr7:150070630 A/G cg10018233 chr7:150070692 REPIN1 0.45 9.0 0.44 1.78e-17 Blood protein levels;Circulating chemerin levels; LUSC cis rs1950500 0.565 rs3181248 chr14:24808168 G/A cg16194253 chr14:24768981 DHRS1;C14orf21 0.6 9.82 0.47 3.65e-20 Height; LUSC cis rs77741769 0.529 rs2893876 chr12:121245158 T/C cg02419362 chr12:121203948 SPPL3 0.45 8.29 0.41 2.83e-15 Mean corpuscular volume; LUSC cis rs694739 0.892 rs647152 chr11:64109118 T/G cg02228329 chr11:64053129 BAD;GPR137 0.52 7.68 0.39 1.75e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7903847 0.642 rs11189177 chr10:99141663 C/T cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.57e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs2839186 0.934 rs17182538 chr21:47705673 C/A cg12379764 chr21:47803548 PCNT -0.43 -5.99 -0.31 5.53e-9 Testicular germ cell tumor; LUSC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg17971929 chr21:40555470 PSMG1 0.77 12.84 0.57 5.9e-31 Cognitive function; LUSC cis rs3741798 1.000 rs61922026 chr12:12486428 C/G cg08615371 chr12:12503544 MANSC1 1.07 10.76 0.51 2.28e-23 Cerebrospinal fluid biomarker levels; LUSC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.72 0.51 3.03e-23 Monocyte percentage of white cells; LUSC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg01657329 chr11:68192670 LRP5 0.45 7.33 0.37 1.71e-12 Total body bone mineral density; LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.12 0.55 2.82e-28 Prudent dietary pattern; LUSC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg26924012 chr15:45694286 SPATA5L1 1.14 21.1 0.76 2.08e-63 Homoarginine levels; LUSC cis rs5769707 0.872 rs5770604 chr22:50030672 G/A cg07959070 chr22:50026188 C22orf34 -0.33 -6.83 -0.35 3.92e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs16866061 0.890 rs72972401 chr2:225404668 T/C cg12698349 chr2:225449008 CUL3 0.87 14.37 0.62 8.48e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg15649852 chr7:65879115 NA -0.41 -5.76 -0.3 1.96e-8 Aortic root size; LUSC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg23719950 chr11:63933701 MACROD1 -0.6 -7.9 -0.4 4.11e-14 Mean platelet volume; LUSC cis rs1832871 0.672 rs56115227 chr6:158773884 G/A cg07165851 chr6:158734300 TULP4 0.47 7.16 0.36 5.04e-12 Height; LUSC cis rs35306767 0.714 rs12783621 chr10:1083304 C/T cg26597838 chr10:835615 NA 0.56 7.33 0.37 1.74e-12 Eosinophil percentage of granulocytes; LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC trans rs11098499 0.908 rs7696649 chr4:120322177 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg23711669 chr6:146136114 FBXO30 0.7 12.24 0.56 1.03e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs12286929 0.639 rs4938181 chr11:115041163 A/G cg04055981 chr11:115044050 NA 0.44 8.05 0.4 1.44e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.51 -8.46 -0.42 8.42e-16 IgG glycosylation; LUSC cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg11871910 chr12:69753446 YEATS4 0.73 11.28 0.53 3.1e-25 Cerebrospinal fluid biomarker levels; LUSC cis rs36405 0.500 rs8003168 chr14:72363388 A/G cg23396177 chr14:72358413 NA -0.34 -6.39 -0.33 5.6e-10 Yang-deficiency constitution; LUSC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.43 -6.79 -0.35 5.04e-11 Alzheimer's disease (late onset); LUSC cis rs16976116 0.951 rs11857087 chr15:55487181 T/A cg11288833 chr15:55489084 RSL24D1 0.48 5.69 0.3 2.8e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg04317338 chr11:64019027 PLCB3 0.67 7.69 0.39 1.71e-13 Mean platelet volume; LUSC cis rs9473147 0.602 rs9296567 chr6:47553402 G/A cg20196966 chr6:47445060 CD2AP 0.43 6.05 0.31 3.86e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs634534 0.562 rs642293 chr11:65730217 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.49 7.49 0.38 6.36e-13 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.19 -0.32 1.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3125734 0.633 rs6479791 chr10:63980341 T/C cg09941381 chr10:64027924 RTKN2 -0.39 -7.36 -0.37 1.43e-12 Rheumatoid arthritis; LUSC cis rs9420 0.528 rs34052104 chr11:57384519 A/C cg23127183 chr11:57508653 C11orf31 -0.47 -6.57 -0.34 1.95e-10 Schizophrenia; LUSC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg02079420 chr8:82753780 SNX16 0.41 7.01 0.36 1.29e-11 Diastolic blood pressure; LUSC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.8 -0.35 4.89e-11 Lung cancer; LUSC cis rs981844 1.000 rs116588966 chr4:154664794 T/C cg10279832 chr4:154682576 RNF175 -0.4 -5.85 -0.3 1.19e-8 Response to statins (LDL cholesterol change); LUSC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg07701084 chr6:150067640 NUP43 0.57 8.77 0.43 9.32e-17 Lung cancer; LUSC cis rs2637266 0.935 rs7909808 chr10:78392318 A/G cg18941641 chr10:78392320 NA 0.4 7.34 0.37 1.66e-12 Pulmonary function; LUSC cis rs453301 0.506 rs686189 chr8:8623637 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -8.92 -0.44 3.05e-17 Joint mobility (Beighton score); LUSC cis rs11997175 0.646 rs4612298 chr8:33713451 G/A ch.8.33884649F chr8:33765107 NA 0.46 7.0 0.36 1.44e-11 Body mass index; LUSC cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg05868516 chr6:26286170 HIST1H4H 0.36 5.8 0.3 1.58e-8 Educational attainment; LUSC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.17 -0.32 1.97e-9 Lung cancer; LUSC cis rs9815354 0.680 rs73830596 chr3:42028223 G/A cg03022575 chr3:42003672 ULK4 0.71 7.27 0.37 2.5e-12 Pulse pressure;Diastolic blood pressure; LUSC cis rs7937682 0.562 rs12275761 chr11:111367083 T/A cg09085632 chr11:111637200 PPP2R1B 0.5 6.97 0.36 1.67e-11 Primary sclerosing cholangitis; LUSC cis rs13006833 0.668 rs2582770 chr2:191136794 A/C cg21644426 chr2:191273491 MFSD6 0.45 6.36 0.33 6.83e-10 Urinary metabolites; LUSC cis rs941873 0.868 rs1483733 chr10:81130036 A/G cg09469691 chr10:81107165 PPIF 0.56 8.33 0.41 2.08e-15 Height; LUSC cis rs72781680 0.848 rs6754694 chr2:24155448 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.12 0.32 2.59e-9 Lymphocyte counts; LUSC cis rs7851660 0.809 rs9299258 chr9:100666543 T/G cg13688889 chr9:100608707 NA -0.54 -8.43 -0.42 1.05e-15 Strep throat; LUSC cis rs9287719 0.967 rs6721739 chr2:10751246 G/T cg00105475 chr2:10696890 NA -0.38 -6.39 -0.33 5.66e-10 Prostate cancer; LUSC cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg03146154 chr1:46216737 IPP 0.54 8.24 0.41 4e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9467711 0.790 rs66488313 chr6:26631568 G/T cg09904177 chr6:26538194 HMGN4 -0.78 -5.7 -0.3 2.64e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7267979 1.000 rs6083825 chr20:25366424 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg17252645 chr8:143867129 LY6D 0.38 6.7 0.34 8.75e-11 Urinary tract infection frequency; LUSC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg26597838 chr10:835615 NA 0.99 13.99 0.61 2.53e-35 Eosinophil percentage of granulocytes; LUSC cis rs870825 0.616 rs6817521 chr4:185649827 A/G cg04058563 chr4:185651563 MLF1IP -0.83 -13.01 -0.58 1.36e-31 Blood protein levels; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg00431813 chr7:1051703 C7orf50 -0.37 -5.79 -0.3 1.6e-8 Longevity;Endometriosis; LUSC cis rs72781680 0.898 rs72786278 chr2:24063243 C/T cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs4423214 1.000 rs4944955 chr11:71167677 C/T cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.38e-24 Vitamin D levels; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg22963979 chr7:1858916 MAD1L1 -0.74 -12.73 -0.57 1.57e-30 Bipolar disorder and schizophrenia; LUSC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg00784671 chr22:46762841 CELSR1 -0.48 -5.97 -0.31 6.04e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7267979 1.000 rs2258563 chr20:25273435 C/T cg03522245 chr20:25566470 NINL 0.36 5.75 0.3 2e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg21545522 chr1:205238299 TMCC2 0.49 9.2 0.45 3.93e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs865483 0.895 rs2522965 chr17:35816318 C/G cg06716730 chr17:35851459 DUSP14 0.27 6.04 0.31 4.13e-9 Monocyte count; LUSC cis rs7945718 0.806 rs7927346 chr11:12835835 C/T cg25843174 chr11:12811716 TEAD1 0.31 7.12 0.36 6.45e-12 Educational attainment (years of education); LUSC cis rs2439831 0.867 rs28415933 chr15:43635800 T/C cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.16 0.58 3.88e-32 Lung cancer in ever smokers; LUSC cis rs12620999 0.838 rs7589198 chr2:237967615 C/T cg23555395 chr2:238036564 NA 0.4 6.85 0.35 3.56e-11 Systemic lupus erythematosus; LUSC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg20891283 chr12:69753455 YEATS4 0.93 17.88 0.7 1.24e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg12963246 chr6:28129442 ZNF389 0.41 6.35 0.33 6.93e-10 Parkinson's disease; LUSC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.14 -0.32 2.36e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg01028140 chr2:1542097 TPO -0.6 -7.99 -0.4 2.16e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg04121214 chr22:50244548 NA -0.34 -5.69 -0.3 2.79e-8 Schizophrenia; LUSC cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.86 -0.44 4.84e-17 Monocyte percentage of white cells; LUSC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -7.7 -0.39 1.54e-13 Tuberculosis; LUSC cis rs1048238 0.506 rs12039892 chr1:16167974 A/G cg22431228 chr1:16359049 CLCNKA -0.42 -8.34 -0.42 2.02e-15 Systolic blood pressure; LUSC cis rs6738485 0.507 rs66569888 chr2:106886967 G/A cg16099169 chr2:106886729 NA -0.53 -6.45 -0.33 3.86e-10 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.56 0.38 4.05e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10744422 1.000 rs3852536 chr12:123333824 C/T cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.14e-12 Schizophrenia; LUSC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg12463550 chr7:65579703 CRCP -0.55 -8.23 -0.41 4.3e-15 Aortic root size; LUSC cis rs11190604 0.767 rs10883484 chr10:102174803 G/C cg07080220 chr10:102295463 HIF1AN 0.59 7.61 0.38 2.86e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg21775979 chr11:780331 NA 0.41 6.71 0.34 8.57e-11 Breast cancer; LUSC cis rs8062405 0.755 rs55792032 chr16:28599411 A/G cg16576597 chr16:28551801 NUPR1 0.3 6.24 0.32 1.34e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7189233 0.955 rs72801817 chr16:53474568 C/T cg04059762 chr16:53544020 NA -0.32 -5.83 -0.3 1.32e-8 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.659 rs17222621 chr17:56695923 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.59 0.6 9.01e-34 Cognitive test performance; LUSC cis rs6500602 0.826 rs11076831 chr16:4460133 A/G cg08645402 chr16:4508243 NA -0.48 -7.35 -0.37 1.56e-12 Schizophrenia; LUSC cis rs6489882 0.867 rs4766676 chr12:113365581 A/G cg20102336 chr12:113376681 OAS3 0.41 5.97 0.31 6.01e-9 Chronic lymphocytic leukemia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18802567 chr5:171433913 FBXW11 0.46 7.2 0.37 4.13e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.39e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2235649 0.828 rs9938694 chr16:1849872 T/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.18 -0.32 1.84e-9 Blood metabolite levels; LUSC cis rs372883 0.901 rs407463 chr21:30722440 G/A cg24692254 chr21:30365293 RNF160 -0.41 -5.86 -0.31 1.14e-8 Pancreatic cancer; LUSC cis rs6701037 1.000 rs7514749 chr1:175122123 A/G cg00321850 chr1:175162397 KIAA0040 -0.44 -7.52 -0.38 5.14e-13 Alcohol dependence; LUSC cis rs1865760 0.865 rs9467652 chr6:25959127 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.9 0.35 2.67e-11 Height; LUSC cis rs6669072 0.647 rs698274 chr1:91244177 A/G cg08895590 chr1:91227319 NA -0.38 -8.51 -0.42 6.02e-16 Cognitive function; LUSC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.11e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg06600287 chr1:53387719 ECHDC2 -0.29 -6.27 -0.32 1.15e-9 Monocyte count; LUSC cis rs9467773 0.526 rs3734536 chr6:26365346 C/G cg09904177 chr6:26538194 HMGN4 -0.47 -7.35 -0.37 1.5e-12 Intelligence (multi-trait analysis); LUSC cis rs7258465 0.931 rs875396 chr19:18611147 A/G cg15073853 chr19:18549131 ISYNA1 -0.33 -5.97 -0.31 5.91e-9 Breast cancer; LUSC cis rs1577917 0.958 rs10944136 chr6:86448499 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.85 -0.44 5.13e-17 Response to antipsychotic treatment; LUSC cis rs1178127 0.580 rs17139842 chr7:18800697 C/G cg02370815 chr7:18831390 HDAC9 -0.42 -6.17 -0.32 2.02e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); LUSC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg19592336 chr6:28129416 ZNF389 0.48 6.3 0.33 9.46e-10 Depression; LUSC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg10253484 chr15:75165896 SCAMP2 -0.46 -6.64 -0.34 1.24e-10 Breast cancer; LUSC cis rs2230307 0.572 rs512999 chr1:100563330 A/G cg24955406 chr1:100503596 HIAT1 0.59 6.36 0.33 6.62e-10 Carotid intima media thickness; LUSC cis rs9457247 1.000 rs408040 chr6:167398903 A/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.74 -0.35 6.85e-11 Crohn's disease; LUSC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.61 9.15 0.45 5.97e-18 Height; LUSC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg13206674 chr6:150067644 NUP43 0.6 9.7 0.47 9.47e-20 Lung cancer; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg11494091 chr17:61959527 GH2 0.65 13.73 0.6 2.53e-34 Prudent dietary pattern; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25266327 chr19:16435660 KLF2 -0.47 -6.48 -0.33 3.23e-10 Bipolar disorder and schizophrenia; LUSC trans rs10802346 0.545 rs4607841 chr1:246373295 T/C cg13514129 chr1:39547527 MACF1 0.73 11.88 0.55 2.1e-27 Fractional exhaled nitric oxide (childhood); LUSC trans rs637571 0.584 rs7107912 chr11:65603252 G/A cg17712092 chr4:129076599 LARP1B -0.82 -12.09 -0.55 3.78e-28 Eosinophil percentage of white cells; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg00684032 chr4:1343700 KIAA1530 0.41 7.34 0.37 1.6e-12 Obesity-related traits; LUSC cis rs6430585 0.527 rs57530667 chr2:136444338 A/G cg07169764 chr2:136633963 MCM6 1.06 14.11 0.61 8.61e-36 Corneal structure; LUSC cis rs10193935 1.000 rs10173107 chr2:42420302 A/T cg27598129 chr2:42591480 NA -0.62 -8.48 -0.42 7.18e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg13319975 chr6:146136371 FBXO30 -0.7 -10.69 -0.5 3.9e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.96 0.55 1.14e-27 Personality dimensions; LUSC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg21724239 chr8:58056113 NA 0.55 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.91 15.51 0.65 2.93e-41 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1014246 0.848 rs10749227 chr10:118468631 G/C cg14919929 chr10:118506882 NA 0.43 6.47 0.33 3.43e-10 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2742234 0.541 rs7073849 chr10:43740474 G/C cg07801480 chr10:43725741 RASGEF1A -0.39 -5.88 -0.31 1.02e-8 Hirschsprung disease; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg01879757 chr17:41196368 BRCA1 -0.46 -7.0 -0.36 1.42e-11 Menopause (age at onset); LUSC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg06640241 chr16:89574553 SPG7 0.85 15.08 0.64 1.43e-39 Multiple myeloma (IgH translocation); LUSC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg24110177 chr3:50126178 RBM5 -0.53 -8.73 -0.43 1.28e-16 Intelligence (multi-trait analysis); LUSC cis rs17401966 0.838 rs9332414 chr1:10326963 C/T cg19773385 chr1:10388646 KIF1B -0.5 -8.83 -0.44 5.98e-17 Hepatocellular carcinoma; LUSC cis rs6121246 0.567 rs6060263 chr20:30193110 T/C cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs943466 0.513 rs943467 chr6:33731811 A/T cg25922239 chr6:33757077 LEMD2 0.4 5.65 0.3 3.42e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; LUSC cis rs2204008 0.619 rs8189576 chr12:38307275 G/A cg26384229 chr12:38710491 ALG10B -0.57 -8.5 -0.42 6.4e-16 Bladder cancer; LUSC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg07424592 chr7:64974309 NA 0.69 6.07 0.32 3.41e-9 Diabetic kidney disease; LUSC cis rs416603 0.967 rs7191538 chr16:11363389 C/G cg00044050 chr16:11439710 C16orf75 -0.68 -12.11 -0.55 3.25e-28 Type 1 diabetes; LUSC cis rs8060686 0.641 rs1125333 chr16:68227566 C/A cg09835421 chr16:68378352 PRMT7 -0.54 -5.91 -0.31 8.4e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg08470875 chr2:26401718 FAM59B 0.62 8.51 0.42 5.98e-16 Gut microbiome composition (summer); LUSC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg04248312 chr19:17393744 ANKLE1 -1.0 -16.83 -0.68 1.77e-46 Systemic lupus erythematosus; LUSC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.33 5.72 0.3 2.33e-8 Parkinson's disease; LUSC cis rs868036 1.000 rs4776376 chr15:68093435 G/A cg05925327 chr15:68127851 NA -0.32 -5.7 -0.3 2.67e-8 Restless legs syndrome; LUSC cis rs10162002 1.000 rs17078796 chr13:24043830 A/G cg00158254 chr13:24040743 NA -0.58 -6.5 -0.34 2.94e-10 Hypothyroidism; LUSC cis rs9815354 0.868 rs1716653 chr3:41975598 C/A cg03022575 chr3:42003672 ULK4 -0.59 -6.52 -0.34 2.53e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs1858037 0.867 rs61226353 chr2:65590771 G/A cg08085232 chr2:65598271 SPRED2 -0.39 -5.73 -0.3 2.3e-8 Rheumatoid arthritis; LUSC cis rs61931739 0.534 rs11053073 chr12:34202412 C/T cg06521331 chr12:34319734 NA -0.46 -7.55 -0.38 4.16e-13 Morning vs. evening chronotype; LUSC cis rs1018697 1.000 rs7086400 chr10:104562097 G/A cg04362960 chr10:104952993 NT5C2 0.48 6.59 0.34 1.74e-10 Colorectal adenoma (advanced); LUSC cis rs7216064 1.000 rs4791212 chr17:65975385 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.52 -0.46 3.49e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg22508957 chr16:3507546 NAT15 -0.92 -10.64 -0.5 5.74e-23 Tuberculosis; LUSC cis rs7561273 0.565 rs6545275 chr2:24331860 A/G cg20701182 chr2:24300061 SF3B14 0.51 6.55 0.34 2.19e-10 Quantitative traits; LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg27535305 chr1:53392650 SCP2 0.37 6.79 0.35 5.29e-11 Monocyte count; LUSC cis rs72901758 0.768 rs72901762 chr17:76244926 A/G cg25512537 chr17:76250053 NA 0.49 8.64 0.43 2.33e-16 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs4843747 0.605 rs28399183 chr16:88107277 G/A cg26811252 chr16:29126840 RRN3P2 0.58 9.33 0.45 1.5e-18 Menopause (age at onset); LUSC cis rs7584330 0.666 rs7600317 chr2:238353513 C/T cg14458575 chr2:238380390 NA 0.77 13.36 0.59 6.69e-33 Prostate cancer; LUSC cis rs75804782 0.520 rs34058921 chr2:239318665 C/T cg18131467 chr2:239335373 ASB1 -0.74 -6.64 -0.34 1.28e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7605827 0.930 rs3805104 chr2:15535147 C/T cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.31e-17 Educational attainment (years of education); LUSC cis rs2439831 0.764 rs2447193 chr15:43929733 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC cis rs7119 0.604 rs907383 chr15:77870646 A/G cg27398640 chr15:77910606 LINGO1 0.35 7.71 0.39 1.49e-13 Type 2 diabetes; LUSC trans rs868943 0.582 rs12210252 chr6:116477493 G/T cg01703780 chr2:192353242 NA 0.34 5.94 0.31 7.01e-9 Total cholesterol levels; LUSC cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg15605315 chr1:45957053 TESK2 -0.43 -6.59 -0.34 1.73e-10 High light scatter reticulocyte count; LUSC cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC trans rs2392780 0.536 rs594154 chr8:128334911 G/A cg10897648 chr18:56338258 MALT1 -0.41 -6.17 -0.32 1.92e-9 Breast cancer (early onset); LUSC cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -7.99 -0.4 2.18e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -7.11 -0.36 7.15e-12 Alzheimer's disease (late onset); LUSC cis rs35146811 0.735 rs6465766 chr7:99785671 A/G cg19116668 chr7:99932089 PMS2L1 -0.33 -5.65 -0.3 3.49e-8 Coronary artery disease; LUSC cis rs4919087 0.962 rs10882891 chr10:99059645 C/A cg25902810 chr10:99078978 FRAT1 0.49 7.18 0.37 4.51e-12 Monocyte count; LUSC trans rs9380880 0.826 rs2273062 chr6:39550935 C/A cg14673904 chr12:46609063 SLC38A1 0.54 5.99 0.31 5.41e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs9549367 0.713 rs553316 chr13:113838015 A/G cg00898013 chr13:113819073 PROZ 0.55 8.22 0.41 4.58e-15 Platelet distribution width; LUSC cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg07148914 chr20:33460835 GGT7 0.54 8.25 0.41 3.63e-15 Height; LUSC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg09165964 chr15:75287851 SCAMP5 -1.15 -19.33 -0.73 2.1e-56 Blood trace element (Zn levels); LUSC cis rs694739 0.536 rs671976 chr11:64046029 G/A cg26318627 chr11:63887540 MACROD1 -0.32 -6.11 -0.32 2.71e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7246967 0.673 rs2361245 chr19:22834530 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs6565180 1.000 rs6565180 chr16:30361341 G/T cg17640201 chr16:30407289 ZNF48 -0.87 -15.27 -0.64 2.6e-40 Tonsillectomy; LUSC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.18 -0.41 6e-15 Platelet count; LUSC cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg15103426 chr22:29168792 CCDC117 0.45 5.77 0.3 1.81e-8 Lymphocyte counts; LUSC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg16447950 chr5:562315 NA -0.53 -6.97 -0.36 1.69e-11 Obesity-related traits; LUSC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11644478 chr21:40555479 PSMG1 -0.65 -10.02 -0.48 7.56e-21 Menarche (age at onset); LUSC cis rs7772486 0.902 rs2777480 chr6:146309983 T/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.76 -0.35 6.04e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg00884529 chr7:16685823 BZW2;ANKMY2 0.51 6.13 0.32 2.52e-9 Cognitive function;Information processing speed; LUSC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC cis rs11992162 0.569 rs35283519 chr8:11831661 C/T cg20542592 chr8:11973495 FAM66D 0.45 5.82 0.3 1.41e-8 Monocyte count; LUSC cis rs3008870 0.958 rs12143044 chr1:67460054 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs6138458 1.000 rs4273288 chr20:24900873 G/A cg06937882 chr20:24974362 C20orf3 0.42 7.0 0.36 1.43e-11 Blood protein levels; LUSC trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg17470723 chr8:74884337 TCEB1 0.52 8.2 0.41 5.26e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg23590916 chr17:43697445 MGC57346 0.5 6.67 0.34 1.08e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -11.98 -0.55 9.35e-28 Platelet count; LUSC cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01755729 chr8:146012904 ZNF34 0.68 6.18 0.32 1.82e-9 Cognitive performance; LUSC trans rs57046232 0.531 rs6054146 chr20:6335865 G/T cg17788362 chr6:86352627 SYNCRIP 0.42 6.1 0.32 2.95e-9 Colorectal cancer; LUSC cis rs9790314 1.000 rs7647327 chr3:161016421 T/C cg03342759 chr3:160939853 NMD3 -0.5 -8.44 -0.42 9.95e-16 Morning vs. evening chronotype; LUSC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg12963246 chr6:28129442 ZNF389 0.48 5.88 0.31 1.01e-8 Depression; LUSC cis rs7949030 0.754 rs36104523 chr11:62395740 A/T cg22862634 chr11:62369728 EML3;MTA2 -0.5 -8.3 -0.41 2.53e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12802244 1 rs12802244 chr11:47932666 G/A cg18512352 chr11:47633146 NA -0.41 -8.15 -0.41 7.45e-15 Neuroticism; LUSC cis rs11997175 0.549 rs4357253 chr8:33652458 G/A ch.8.33884649F chr8:33765107 NA 0.52 8.57 0.42 3.9e-16 Body mass index; LUSC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.4 -8.0 -0.4 2.04e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs1577917 0.916 rs7759727 chr6:86518878 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.22 -0.32 1.48e-9 Response to antipsychotic treatment; LUSC cis rs72781680 0.800 rs72780112 chr2:23991182 C/T cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs4363385 0.647 rs7548977 chr1:152987365 T/G cg00922841 chr1:152955080 SPRR1A -0.38 -6.18 -0.32 1.83e-9 Inflammatory skin disease; LUSC cis rs10905065 0.827 rs10752111 chr10:5837286 T/C cg11519256 chr10:5708881 ASB13 0.4 5.78 0.3 1.7e-8 Menopause (age at onset); LUSC cis rs12980942 0.630 rs11881940 chr19:41808432 A/T cg25627403 chr19:41769009 HNRNPUL1 0.61 6.59 0.34 1.68e-10 Coronary artery disease; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg08736216 chr1:53307985 ZYG11A -0.3 -6.51 -0.34 2.8e-10 Monocyte count; LUSC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.25 -0.41 3.64e-15 Joint mobility (Beighton score); LUSC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg23711669 chr6:146136114 FBXO30 -0.74 -13.05 -0.58 1.02e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs6502050 0.842 rs6502053 chr17:80066714 C/T cg13939156 chr17:80058883 NA 0.33 6.51 0.34 2.73e-10 Life satisfaction; LUSC cis rs9359856 0.564 rs6914142 chr6:90398903 C/T cg13799429 chr6:90582589 CASP8AP2 -0.86 -8.75 -0.43 1.09e-16 Bipolar disorder; LUSC cis rs2573652 0.722 rs12595247 chr15:100541689 C/T cg00587665 chr15:100533223 ADAMTS17 -0.39 -7.0 -0.36 1.38e-11 Height; LUSC cis rs8016982 0.674 rs6574631 chr14:81675772 C/T cg01989461 chr14:81687754 GTF2A1 0.74 13.33 0.59 8.29e-33 Schizophrenia; LUSC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg04871131 chr7:94954202 PON1 -0.4 -6.2 -0.32 1.67e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs497273 0.517 rs580240 chr12:121199903 T/G cg02419362 chr12:121203948 SPPL3 0.43 7.9 0.4 3.94e-14 Systemic lupus erythematosus; LUSC cis rs73198271 0.740 rs10105690 chr8:8649232 G/T cg01851573 chr8:8652454 MFHAS1 0.55 9.18 0.45 4.78e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs74181299 0.964 rs2723065 chr2:65279414 A/G cg05010058 chr2:65284262 CEP68 0.31 6.2 0.32 1.67e-9 Pulse pressure; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg14092988 chr3:52407081 DNAH1 0.31 6.18 0.32 1.82e-9 Bipolar disorder; LUSC cis rs3820068 0.705 rs4646072 chr1:15827711 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.3 1.45e-8 Systolic blood pressure; LUSC trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs2637266 0.935 rs2579720 chr10:78399918 T/C cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC cis rs1577917 1.000 rs10455449 chr6:86592226 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.87 -0.35 3.12e-11 Response to antipsychotic treatment; LUSC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg11752832 chr7:134001865 SLC35B4 0.55 8.65 0.43 2.28e-16 Mean platelet volume; LUSC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg27494647 chr7:150038898 RARRES2 0.49 7.47 0.38 6.9e-13 Blood protein levels;Circulating chemerin levels; LUSC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg15704280 chr7:45808275 SEPT13 -1.08 -21.89 -0.77 1.67e-66 Height; LUSC cis rs1451375 0.572 rs4948205 chr7:50557774 G/A cg18232548 chr7:50535776 DDC -0.53 -7.47 -0.38 6.91e-13 Malaria; LUSC cis rs651907 0.737 rs9844218 chr3:101584983 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.57 -7.76 -0.39 1.01e-13 Colorectal cancer; LUSC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg26335602 chr6:28129616 ZNF389 0.46 6.13 0.32 2.5e-9 Depression; LUSC cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg24375607 chr4:120327624 NA 0.77 11.27 0.53 3.36e-25 Corneal astigmatism; LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg19592336 chr6:28129416 ZNF389 0.54 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs6754311 0.509 rs12616520 chr2:136516748 A/T cg07169764 chr2:136633963 MCM6 -0.72 -9.84 -0.47 3.19e-20 Mosquito bite size; LUSC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg02915803 chr1:1606292 LOC728661;CDK11B 0.37 5.78 0.3 1.76e-8 Body mass index; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10163222 chr19:45004637 ZNF180 0.77 6.1 0.32 2.95e-9 Cognitive performance; LUSC trans rs9929218 0.529 rs8060790 chr16:68729112 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.06 23.53 0.79 6.92e-73 Colorectal cancer; LUSC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg03676636 chr4:99064102 C4orf37 -0.33 -7.12 -0.36 6.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.903 rs6050481 chr20:25224580 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.27 0.71 3.52e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs782590 0.738 rs4312532 chr2:55812061 A/G cg03859395 chr2:55845619 SMEK2 -0.8 -13.47 -0.59 2.51e-33 Metabolic syndrome; LUSC cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg15103426 chr22:29168792 CCDC117 0.45 5.98 0.31 5.88e-9 Lymphocyte counts; LUSC cis rs1728785 0.688 rs698718 chr16:68560185 A/G cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg04414720 chr1:150670196 GOLPH3L 0.51 7.82 0.39 6.77e-14 Melanoma; LUSC cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg01849466 chr14:104193079 ZFYVE21 0.45 6.78 0.35 5.31e-11 Reticulocyte count; LUSC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg23758822 chr17:41437982 NA 1.04 19.29 0.73 2.97e-56 Menopause (age at onset); LUSC cis rs13031619 0.607 rs13011199 chr2:3694994 A/G cg00999904 chr2:3704751 ALLC 0.32 5.73 0.3 2.25e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs11645898 0.683 rs72787038 chr16:72066102 A/C cg14768367 chr16:72042858 DHODH -0.59 -6.74 -0.35 7.12e-11 Blood protein levels; LUSC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg19717773 chr7:2847554 GNA12 -0.39 -6.0 -0.31 5.14e-9 Height; LUSC cis rs4423214 0.840 rs1792229 chr11:71179395 A/G cg05163923 chr11:71159392 DHCR7 -0.78 -9.97 -0.48 1.18e-20 Vitamin D levels; LUSC cis rs4631830 0.863 rs2843550 chr10:51521452 C/T cg16070123 chr10:51489643 NA -0.51 -8.08 -0.4 1.23e-14 Prostate-specific antigen levels; LUSC trans rs877282 0.797 rs11253329 chr10:753200 A/T cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg18765753 chr7:1198926 ZFAND2A -0.46 -8.1 -0.41 1.02e-14 Longevity;Endometriosis; LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg13390004 chr1:15929781 NA 0.42 7.01 0.36 1.31e-11 Systolic blood pressure; LUSC cis rs4343996 0.686 rs4722654 chr7:3336778 A/C cg21248987 chr7:3385318 SDK1 0.36 6.2 0.32 1.67e-9 Motion sickness; LUSC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg09165964 chr15:75287851 SCAMP5 -1.16 -19.7 -0.73 7.33e-58 Blood trace element (Zn levels); LUSC trans rs10792665 0.575 rs4625493 chr11:82540975 C/T cg05721830 chr1:37980522 MEAF6 -0.35 -6.21 -0.32 1.55e-9 Obesity-related traits; LUSC cis rs72949976 0.934 rs1922794 chr2:214026181 G/A cg08319019 chr2:214017104 IKZF2 -0.64 -9.94 -0.48 1.48e-20 Lung cancer;Squamous cell lung carcinoma; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg23420005 chr9:34957718 KIAA1045 0.72 6.14 0.32 2.39e-9 Body mass index; LUSC cis rs7512552 0.809 rs828783 chr1:150376977 C/T cg15654264 chr1:150340011 RPRD2 0.66 10.96 0.51 4.44e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2806561 0.734 rs1952527 chr1:23400969 T/C cg19743168 chr1:23544995 NA 0.39 7.26 0.37 2.8e-12 Height; LUSC cis rs2445762 0.518 rs6493496 chr15:51628119 A/T cg07517944 chr15:51633816 GLDN 0.37 6.89 0.35 2.83e-11 Hormone measurements; LUSC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg00750074 chr16:89608354 SPG7 -0.45 -7.9 -0.4 4.21e-14 Multiple myeloma (IgH translocation); LUSC cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg08999081 chr20:33150536 PIGU -0.54 -10.56 -0.5 1.1e-22 Glomerular filtration rate (creatinine); LUSC trans rs11098499 0.863 rs11723090 chr4:120490592 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.65 0.34 1.22e-10 Corneal astigmatism; LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.99 -0.31 5.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg03060546 chr3:49711283 APEH 0.72 12.22 0.56 1.2e-28 Resting heart rate; LUSC cis rs250677 0.652 rs250670 chr5:148446646 G/T cg23229984 chr5:148520753 ABLIM3 0.41 6.48 0.33 3.22e-10 Breast cancer; LUSC cis rs782590 0.837 rs782585 chr2:55922930 C/T cg18811423 chr2:55921094 PNPT1 0.89 16.03 0.66 2.76e-43 Metabolic syndrome; LUSC cis rs7659604 0.540 rs10004284 chr4:122699222 A/T cg06713675 chr4:122721982 EXOSC9 0.37 6.06 0.31 3.77e-9 Type 2 diabetes; LUSC cis rs477692 0.673 rs579325 chr10:131363688 C/T cg11019008 chr10:131425282 MGMT 0.43 6.22 0.32 1.46e-9 Response to temozolomide; LUSC cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg08807101 chr21:30365312 RNF160 -0.69 -12.08 -0.55 3.97e-28 Dental caries; LUSC cis rs45509595 0.556 rs34409918 chr6:27685348 A/G cg26958806 chr6:27640298 NA 0.72 5.79 0.3 1.65e-8 Breast cancer; LUSC cis rs922692 0.744 rs11072806 chr15:79079074 G/A cg00540400 chr15:79124168 NA -0.4 -7.02 -0.36 1.22e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg08470875 chr2:26401718 FAM59B 0.73 10.0 0.48 9.08e-21 Gut microbiome composition (summer); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02047577 chr20:62587702 UCKL1AS;UCKL1 0.5 6.83 0.35 4e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4786125 0.587 rs1473515 chr16:6923092 T/G cg03623568 chr16:6915990 A2BP1 -0.51 -8.43 -0.42 1.04e-15 Heart rate variability traits (SDNN); LUSC cis rs1178968 1.000 rs6460041 chr7:72757671 A/G cg25889504 chr7:72793014 NA 0.58 7.54 0.38 4.5e-13 Triglyceride levels; LUSC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg23887609 chr12:130822674 PIWIL1 0.48 7.08 0.36 8.43e-12 Menopause (age at onset); LUSC cis rs4808199 0.895 rs8105984 chr19:19374068 T/C cg03709012 chr19:19516395 GATAD2A 0.94 10.71 0.51 3.28e-23 Nonalcoholic fatty liver disease; LUSC cis rs4906332 1.000 rs4900574 chr14:103879024 G/A cg04998671 chr14:104000505 TRMT61A 0.47 7.36 0.37 1.43e-12 Coronary artery disease; LUSC cis rs6424115 0.931 rs11800561 chr1:24164398 T/G cg10978503 chr1:24200527 CNR2 0.49 11.52 0.53 4.34e-26 Immature fraction of reticulocytes; LUSC cis rs929596 0.755 rs6742078 chr2:234672639 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.64 10.77 0.51 2.06e-23 Total bilirubin levels in HIV-1 infection; LUSC cis rs2235642 0.750 rs1894649 chr16:1657284 C/G cg09025071 chr16:1593152 IFT140;TMEM204 0.32 7.48 0.38 6.78e-13 Coronary artery disease; LUSC cis rs7215564 0.558 rs4889876 chr17:78657071 T/G cg23238734 chr17:78661607 RPTOR 0.48 6.16 0.32 2.07e-9 Myopia (pathological); LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg10729496 chr3:10149963 C3orf24 0.58 7.69 0.39 1.61e-13 Alzheimer's disease; LUSC cis rs6847149 0.714 rs6850377 chr4:110814115 T/C cg07850274 chr4:110748770 RRH 0.52 7.2 0.37 3.95e-12 Exercise treadmill test traits; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg13560548 chr3:10150139 C3orf24 0.47 6.6 0.34 1.64e-10 Alzheimer's disease; LUSC cis rs2070433 0.539 rs1008548 chr21:47959692 G/A cg12379764 chr21:47803548 PCNT 0.8 12.1 0.55 3.4e-28 Lymphocyte counts; LUSC cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -6.09 -0.32 3.1e-9 Personality dimensions; LUSC cis rs7572644 0.699 rs937812 chr2:28255302 C/T cg27432699 chr2:27873401 GPN1 -0.52 -7.07 -0.36 9.22e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs500891 0.525 rs6940284 chr6:84063926 T/G cg08257003 chr6:84140564 ME1 0.34 8.4 0.42 1.3e-15 Platelet-derived growth factor BB levels; LUSC cis rs6121246 0.697 rs6088856 chr20:30226543 C/G cg21427119 chr20:30132790 HM13 -0.42 -6.28 -0.32 1.07e-9 Mean corpuscular hemoglobin; LUSC trans rs34421088 0.623 rs2572433 chr8:11101041 C/T cg15556689 chr8:8085844 FLJ10661 0.51 6.98 0.36 1.63e-11 Neuroticism; LUSC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg24250549 chr1:154909240 PMVK 0.58 9.35 0.46 1.28e-18 Prostate cancer; LUSC cis rs10203711 0.966 rs4663939 chr2:239569867 C/A cg14580085 chr2:239553406 NA 0.43 7.39 0.37 1.21e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4889855 0.614 rs7208670 chr17:78494220 T/G cg00066239 chr17:78472159 NA -0.42 -7.0 -0.36 1.41e-11 Fractional excretion of uric acid; LUSC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg08773314 chr2:239334832 ASB1 0.42 9.03 0.44 1.38e-17 Multiple system atrophy; LUSC cis rs300703 0.935 rs300755 chr2:228505 C/T cg21211680 chr2:198530 NA 0.74 7.5 0.38 5.85e-13 Blood protein levels; LUSC cis rs6005807 0.668 rs9620808 chr22:28993331 A/C cg12565055 chr22:29076175 TTC28 0.56 5.97 0.31 6.06e-9 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs9473147 0.516 rs6931478 chr6:47461913 C/A cg12968598 chr6:47444699 CD2AP 0.53 8.0 0.4 2.1e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg08677398 chr8:58056175 NA 0.58 7.13 0.36 6.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs8113142 0.614 rs60001754 chr19:29190250 C/T cg04546413 chr19:29218101 NA 0.44 5.93 0.31 7.76e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs11214589 0.747 rs11214582 chr11:113218050 C/T cg14159747 chr11:113255604 NA 0.24 5.96 0.31 6.4e-9 Neuroticism; LUSC cis rs11997175 0.838 rs7836762 chr8:33667153 A/G ch.8.33884649F chr8:33765107 NA 0.45 6.97 0.36 1.74e-11 Body mass index; LUSC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.68 -10.37 -0.49 5.14e-22 Platelet count; LUSC cis rs7089973 0.604 rs17663670 chr10:116596269 A/C cg25233709 chr10:116636983 FAM160B1 -0.37 -6.64 -0.34 1.3e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9325144 0.560 rs2013804 chr12:38631079 C/T cg26384229 chr12:38710491 ALG10B -0.67 -10.45 -0.5 2.63e-22 Morning vs. evening chronotype; LUSC cis rs7177699 0.557 rs7403593 chr15:79111962 A/G cg15571903 chr15:79123663 NA -0.33 -6.13 -0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs11039798 0.588 rs61932767 chr11:48704806 C/T cg15704280 chr7:45808275 SEPT13 0.7 8.12 0.41 9.08e-15 Axial length; LUSC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6494488 0.500 rs72744788 chr15:65095235 C/T cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg03929089 chr4:120376271 NA -0.44 -6.1 -0.32 2.87e-9 Height; LUSC cis rs137603 0.562 rs137644 chr22:39728139 A/G cg17798944 chr22:39715225 SNORD43;RPL3 -0.51 -8.25 -0.41 3.83e-15 Primary biliary cholangitis; LUSC cis rs4718428 0.705 rs2901311 chr7:66415069 T/C cg12165864 chr7:66369176 NA -0.56 -7.37 -0.37 1.37e-12 Corneal structure; LUSC cis rs12579753 0.827 rs7311917 chr12:82187551 G/T cg07988820 chr12:82153109 PPFIA2 -0.42 -6.12 -0.32 2.62e-9 Resting heart rate; LUSC cis rs955333 0.641 rs73003010 chr6:154903170 T/C cg20019720 chr6:154832845 CNKSR3 0.49 6.51 0.34 2.7e-10 Diabetic kidney disease; LUSC cis rs34779708 0.966 rs17591857 chr10:35499043 A/G cg03585969 chr10:35415529 CREM -0.63 -9.46 -0.46 5.54e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg23158103 chr7:148848205 ZNF398 -0.42 -6.62 -0.34 1.46e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg24642844 chr7:1081250 C7orf50 -0.45 -7.21 -0.37 3.68e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7512552 0.839 rs4581308 chr1:150276872 A/G cg15654264 chr1:150340011 RPRD2 -0.66 -11.21 -0.52 5.91e-25 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs72960926 0.744 rs55792900 chr6:74924010 C/A cg03266952 chr6:74778945 NA -0.77 -6.79 -0.35 5.1e-11 Metabolite levels (MHPG); LUSC cis rs653178 0.501 rs17696736 chr12:112486818 C/T cg10833066 chr12:111807467 FAM109A 0.31 6.0 0.31 5.09e-9 Tonsillectomy;Monocyte count;Eosinophil percentage of white cells;Myocardial infarction;Crohn's disease;Inflammatory bowel disease;Eosinophil counts;Chronic kidney disease;Diastolic blood pressure;Celiac disease;Thyroid peroxidase antibody positivity;Sum eosinophil basophil counts;Blood pressure;Peripheral artery disease;Alopecia areata;Celiac disease or Rheumatoid arthritis;Urate levels;Thyroid peroxidase antibody levels;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs4930103 0.619 rs10769945 chr11:1985127 C/T cg26856596 chr11:1961893 NA 0.33 6.08 0.32 3.25e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs250677 0.798 rs11168080 chr5:148409821 C/T cg23229984 chr5:148520753 ABLIM3 0.39 6.0 0.31 5.22e-9 Breast cancer; LUSC cis rs6060717 0.610 rs1891151 chr20:34612726 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -6.25 -0.32 1.22e-9 Hip circumference adjusted for BMI; LUSC cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg10645314 chr2:3704589 ALLC 0.48 7.22 0.37 3.64e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs559928 0.593 rs112275221 chr11:63936994 C/T cg24687543 chr11:63912206 MACROD1 0.47 5.82 0.3 1.4e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg09365446 chr1:150670422 GOLPH3L -0.54 -8.25 -0.41 3.61e-15 Tonsillectomy; LUSC trans rs9372498 0.505 rs9489493 chr6:118992323 T/C cg07666134 chr16:1331609 NA 0.37 6.18 0.32 1.83e-9 Diastolic blood pressure; LUSC cis rs6845621 0.901 rs7436965 chr4:18917774 G/A cg12196642 chr4:18937545 NA -0.34 -6.43 -0.33 4.3e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs80130819 0.515 rs1793917 chr12:48384944 A/T cg05342945 chr12:48394962 COL2A1 -0.45 -5.69 -0.3 2.74e-8 Prostate cancer; LUSC cis rs6815814 0.950 rs66922907 chr4:38812537 A/G cg02016764 chr4:38805732 TLR1 -0.54 -5.71 -0.3 2.55e-8 Breast cancer; LUSC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg08048268 chr3:133502702 NA -0.38 -6.82 -0.35 4.23e-11 Iron status biomarkers; LUSC cis rs2637266 0.739 rs2395404 chr10:78380513 G/T cg18941641 chr10:78392320 NA 0.37 6.65 0.34 1.21e-10 Pulmonary function; LUSC trans rs877282 0.853 rs11593836 chr10:756715 G/A cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC trans rs7681440 0.869 rs894280 chr4:90760883 C/T cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.08 -0.32 3.28e-9 Dementia with Lewy bodies; LUSC cis rs1865760 0.713 rs2013063 chr6:25994098 C/T cg16482183 chr6:26056742 HIST1H1C 0.47 6.88 0.35 2.95e-11 Height; LUSC cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.49 0.69 4.31e-49 Chronic sinus infection; LUSC cis rs7575217 0.697 rs34429055 chr2:101703696 G/C cg23907051 chr2:101730305 TBC1D8 0.28 7.5 0.38 5.98e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg05347473 chr6:146136440 FBXO30 0.56 9.79 0.47 4.57e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg00990874 chr7:1149470 C7orf50 -0.5 -6.32 -0.33 8.61e-10 Bronchopulmonary dysplasia; LUSC cis rs7809950 0.817 rs3779495 chr7:107250260 G/A cg23024343 chr7:107201750 COG5 0.67 9.92 0.48 1.73e-20 Coronary artery disease; LUSC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg13877915 chr19:58951672 ZNF132 0.49 7.73 0.39 1.32e-13 Uric acid clearance; LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg08859206 chr1:53392774 SCP2 0.5 8.51 0.42 6.03e-16 Monocyte count; LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg25072359 chr17:41440525 NA 0.66 9.47 0.46 5.09e-19 Menopause (age at onset); LUSC cis rs1348850 0.574 rs12988366 chr2:178417945 A/C cg22681709 chr2:178499509 PDE11A 0.42 5.95 0.31 6.93e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg05872129 chr22:39784769 NA -0.59 -10.78 -0.51 1.82e-23 Intelligence (multi-trait analysis); LUSC cis rs12421382 0.659 rs12420684 chr11:109391788 T/C cg16359550 chr11:109292809 C11orf87 0.38 6.51 0.34 2.8e-10 Schizophrenia; LUSC trans rs7829975 0.533 rs1039917 chr8:8718850 C/T cg21775007 chr8:11205619 TDH 0.43 6.13 0.32 2.51e-9 Mood instability; LUSC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.73 11.11 0.52 1.28e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12905574 chr5:134181527 C5orf24 0.37 6.05 0.31 3.85e-9 Asthma; LUSC cis rs9902453 1.000 rs7223786 chr17:28332107 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.56 -8.42 -0.42 1.12e-15 Coffee consumption (cups per day); LUSC cis rs1997103 0.705 rs56301138 chr7:55396555 G/T cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg12419862 chr22:24373484 LOC391322 -0.84 -13.67 -0.6 4.33e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.32 0.41 2.23e-15 Height; LUSC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg08847533 chr14:75593920 NEK9 -0.81 -13.97 -0.61 3.03e-35 Height; LUSC trans rs62103177 0.525 rs62101233 chr18:77724288 C/T cg14227996 chr4:17616232 MED28 0.65 7.06 0.36 9.85e-12 Opioid sensitivity; LUSC cis rs9473147 0.516 rs10948367 chr6:47585615 A/G cg20196966 chr6:47445060 CD2AP 0.43 6.12 0.32 2.62e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs9359856 0.564 rs34766278 chr6:90397132 G/C cg13799429 chr6:90582589 CASP8AP2 -0.83 -8.49 -0.42 7e-16 Bipolar disorder; LUSC cis rs11039100 0.850 rs35746872 chr11:5834335 T/A cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.73 11.45 0.53 7.9e-26 Colorectal cancer; LUSC cis rs3820068 0.608 rs10927831 chr1:16028373 T/G cg13390004 chr1:15929781 NA 0.41 6.79 0.35 5.02e-11 Systolic blood pressure; LUSC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg19622623 chr12:86230825 RASSF9 -0.42 -6.01 -0.31 4.85e-9 Major depressive disorder; LUSC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg18225595 chr11:63971243 STIP1 0.51 6.39 0.33 5.51e-10 Mean platelet volume; LUSC cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg16586182 chr3:47516702 SCAP 0.55 8.64 0.43 2.39e-16 Colorectal cancer; LUSC cis rs7917772 0.582 rs12784963 chr10:104336986 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.7 -0.51 3.58e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg23711669 chr6:146136114 FBXO30 -0.93 -17.64 -0.69 1.1e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg11366901 chr6:160182831 ACAT2 0.94 13.19 0.59 2.77e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg13395646 chr4:1353034 KIAA1530 -0.58 -8.15 -0.41 7.44e-15 Obesity-related traits; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20781819 chr1:173837197 SNORD76;SNORD74;SNORD75;GAS5;ZBTB37 0.36 5.97 0.31 6.14e-9 Asthma; LUSC trans rs2898290 0.622 rs13272061 chr8:11352261 G/T cg08975724 chr8:8085496 FLJ10661 -0.41 -6.07 -0.32 3.44e-9 Systolic blood pressure; LUSC cis rs4363385 0.747 rs2339496 chr1:152970719 C/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.59 -0.38 3.32e-13 Inflammatory skin disease; LUSC cis rs4631830 0.863 rs2249986 chr10:51521684 T/G cg16070123 chr10:51489643 NA -0.52 -8.38 -0.42 1.5e-15 Prostate-specific antigen levels; LUSC cis rs3806843 0.518 rs173471 chr5:140335226 A/G cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9393777 0.513 rs6924727 chr6:26491234 A/G cg12292205 chr6:26970375 C6orf41 -0.62 -7.57 -0.38 3.56e-13 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg00814883 chr7:100076585 TSC22D4 0.67 8.73 0.43 1.24e-16 Platelet count; LUSC cis rs2204008 0.645 rs9989043 chr12:38238505 G/A cg13010199 chr12:38710504 ALG10B -0.48 -7.07 -0.36 9.26e-12 Bladder cancer; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.61 0.43 3.03e-16 Prudent dietary pattern; LUSC cis rs4129767 0.869 rs4969142 chr17:76398304 G/A cg20026190 chr17:76395443 PGS1 0.35 6.0 0.31 5.17e-9 HDL cholesterol; LUSC cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg02017074 chr12:117425053 FBXW8 0.69 7.93 0.4 3.28e-14 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs72772090 0.539 rs11750464 chr5:96113031 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.76 7.47 0.38 7.02e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11890956 chr21:40555474 PSMG1 -0.72 -10.83 -0.51 1.28e-23 Menarche (age at onset); LUSC cis rs62158211 1.000 rs4618068 chr2:114109355 C/T cg17784749 chr2:114082611 LOC440839 0.52 6.19 0.32 1.74e-9 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; LUSC cis rs4363385 0.782 rs2152993 chr1:152991695 C/A cg25856811 chr1:152973957 SPRR3 -0.34 -5.67 -0.3 3.14e-8 Inflammatory skin disease; LUSC cis rs694739 0.628 rs508168 chr11:64135435 G/A cg23796481 chr11:64053134 BAD;GPR137 0.52 8.14 0.41 7.67e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg14004847 chr7:1930337 MAD1L1 -0.53 -8.07 -0.4 1.31e-14 Bipolar disorder and schizophrenia; LUSC trans rs72674100 0.867 rs72880579 chr4:97979244 T/A cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs4714291 0.832 rs9471244 chr6:40092331 A/G cg02267698 chr19:7991119 CTXN1 0.54 8.31 0.41 2.44e-15 Strep throat; LUSC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg24675056 chr1:15929824 NA 0.48 8.27 0.41 3.15e-15 Systolic blood pressure; LUSC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.43 -6.79 -0.35 5.04e-11 Alzheimer's disease (late onset); LUSC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.36 -6.1 -0.32 2.87e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs72781680 0.898 rs10490751 chr2:24001356 A/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7399018 1.000 rs7399018 chr12:51610365 C/T cg25754956 chr12:51612065 POU6F1 -0.87 -11.58 -0.54 2.75e-26 Cisplatin-induced ototoxicity; LUSC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg21724239 chr8:58056113 NA 0.62 7.07 0.36 9.3e-12 Developmental language disorder (linguistic errors); LUSC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg09359103 chr1:154839909 KCNN3 -0.72 -17.45 -0.69 6.51e-49 Prostate cancer; LUSC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg04850211 chr1:228464232 OBSCN 0.32 5.83 0.3 1.28e-8 Diastolic blood pressure; LUSC cis rs1595825 0.838 rs60079260 chr2:198673636 G/A cg10547527 chr2:198650123 BOLL -0.51 -5.77 -0.3 1.82e-8 Ulcerative colitis; LUSC trans rs3808502 0.647 rs7821302 chr8:11236572 T/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.83 -0.39 6.41e-14 Neuroticism; LUSC cis rs9921192 1.000 rs251733 chr16:4321605 A/T cg00021532 chr16:4324280 TFAP4 0.76 13.72 0.6 2.88e-34 Prostate-specific antigen levels; LUSC trans rs61931739 0.529 rs1525900 chr12:33976652 T/G cg13010199 chr12:38710504 ALG10B 0.4 6.05 0.31 3.86e-9 Morning vs. evening chronotype; LUSC cis rs13720 0.722 rs163795 chr20:57577505 C/G cg23907860 chr20:57583709 CTSZ -0.42 -5.75 -0.3 2.02e-8 Platelet distribution width; LUSC cis rs6669072 0.835 rs12046172 chr1:91325323 T/G cg08895590 chr1:91227319 NA -0.32 -6.78 -0.35 5.51e-11 Cognitive function; LUSC trans rs8072100 0.967 rs7221548 chr17:45582952 T/C cg04995722 chr7:26192034 NFE2L3 0.36 5.95 0.31 6.93e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13057196 chr4:8442503 ACOX3 -0.42 -6.22 -0.32 1.53e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg03354898 chr7:1950403 MAD1L1 -0.34 -6.66 -0.34 1.15e-10 Bipolar disorder and schizophrenia; LUSC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg27068330 chr11:65405492 SIPA1 -0.46 -5.96 -0.31 6.51e-9 Breast cancer; LUSC cis rs13031619 0.517 rs10864995 chr2:3683557 C/T cg19052272 chr2:3704530 ALLC -0.43 -6.12 -0.32 2.56e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs2262909 0.853 rs56207853 chr19:22292357 C/T cg05197062 chr11:11642011 GALNTL4 0.52 7.29 0.37 2.22e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs62103177 0.608 rs59300126 chr18:77694439 C/A cg05926928 chr17:57297772 GDPD1 1.21 14.34 0.62 1.11e-36 Opioid sensitivity; LUSC cis rs1348850 0.801 rs11890163 chr2:178327134 G/A cg22681709 chr2:178499509 PDE11A -0.42 -5.76 -0.3 1.91e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg09904177 chr6:26538194 HMGN4 -0.39 -5.69 -0.3 2.76e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs10493773 0.674 rs414618 chr1:86220418 G/A cg17807903 chr1:86174739 ZNHIT6 0.43 10.64 0.5 6.01e-23 Urate levels in overweight individuals; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg10729496 chr3:10149963 C3orf24 0.56 7.51 0.38 5.4e-13 Alzheimer's disease; LUSC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg04414720 chr1:150670196 GOLPH3L -0.42 -6.47 -0.33 3.51e-10 Tonsillectomy; LUSC cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg26384229 chr12:38710491 ALG10B 0.94 17.87 0.7 1.34e-50 Heart rate; LUSC cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg20821713 chr7:1055600 C7orf50 -0.5 -7.31 -0.37 1.99e-12 Bronchopulmonary dysplasia; LUSC cis rs6121246 0.567 rs6060344 chr20:30207316 A/G cg13852791 chr20:30311386 BCL2L1 0.77 8.74 0.43 1.15e-16 Mean corpuscular hemoglobin; LUSC trans rs76248362 0.881 rs7328209 chr13:24434624 G/A cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC trans rs7395662 0.591 rs12807777 chr11:48593754 A/T cg03929089 chr4:120376271 NA -0.44 -6.03 -0.31 4.27e-9 HDL cholesterol; LUSC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.81 0.35 4.51e-11 Menarche (age at onset); LUSC cis rs4629710 0.568 rs9492883 chr6:131573872 A/T cg12700074 chr6:131571435 AKAP7 -0.35 -5.9 -0.31 8.89e-9 Multiple myeloma (IgH translocation); LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.82 -0.47 3.69e-20 Chronic sinus infection; LUSC cis rs478304 0.627 rs11604568 chr11:65511336 G/A cg05805236 chr11:65401703 PCNXL3 -0.56 -9.1 -0.45 8.47e-18 Acne (severe); LUSC cis rs2245008 0.671 rs907036 chr16:83989850 A/T cg27171569 chr16:83987465 OSGIN1 0.64 13.57 0.6 9.94e-34 Pursuit maintenance gain; LUSC cis rs9583531 0.891 rs61969072 chr13:111380701 T/G cg24331049 chr13:111365604 ING1 -0.65 -7.42 -0.38 9.53e-13 Coronary artery disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg20260663 chr12:56211576 ORMDL2;SARNP 0.37 5.97 0.31 6.2e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11890956 chr21:40555474 PSMG1 -0.85 -15.07 -0.64 1.55e-39 Cognitive function; LUSC cis rs8017423 0.967 rs8021881 chr14:90722276 T/C cg14092571 chr14:90743983 NA -0.36 -5.86 -0.31 1.11e-8 Mortality in heart failure; LUSC cis rs60154123 0.772 rs628908 chr1:210428002 C/T cg22029157 chr1:209979665 IRF6 0.58 5.96 0.31 6.51e-9 Coronary artery disease; LUSC cis rs6430585 0.528 rs6750549 chr2:136707480 A/G cg07169764 chr2:136633963 MCM6 1.15 18.77 0.72 3.45e-54 Corneal structure; LUSC cis rs6542838 0.611 rs7423519 chr2:99518319 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.43 -5.82 -0.3 1.39e-8 Fear of minor pain; LUSC cis rs7618501 1.000 rs1049256 chr3:49763338 T/C cg13072238 chr3:49761600 GMPPB -0.39 -6.43 -0.33 4.5e-10 Intelligence (multi-trait analysis); LUSC trans rs2739330 0.796 rs1006771 chr22:24314006 G/T cg06437703 chr8:37914619 EIF4EBP1 -0.48 -6.95 -0.36 1.97e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10979 0.557 rs9390117 chr6:143907590 C/T cg25407410 chr6:143891975 LOC285740 -0.65 -8.19 -0.41 5.6e-15 Hypospadias; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg03790207 chr6:42947109 PEX6 -0.46 -7.06 -0.36 9.53e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7215564 0.818 rs35638109 chr17:78657367 C/T cg23238734 chr17:78661607 RPTOR 0.48 6.16 0.32 2.07e-9 Myopia (pathological); LUSC cis rs4730250 0.707 rs6960148 chr7:106786142 A/G cg02696742 chr7:106810147 HBP1 0.65 9.18 0.45 4.72e-18 Osteoarthritis; LUSC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg11663144 chr21:46675770 NA 0.38 6.64 0.34 1.24e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7659604 0.521 rs6822155 chr4:122673274 C/A cg19748678 chr4:122722346 EXOSC9 -0.41 -6.06 -0.31 3.7e-9 Type 2 diabetes; LUSC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg16414030 chr3:133502952 NA -0.48 -7.6 -0.38 3.02e-13 Iron status biomarkers; LUSC cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.45 -0.42 8.92e-16 Schizophrenia; LUSC cis rs60154123 0.614 rs661190 chr1:210458697 G/T cg22029157 chr1:209979665 IRF6 0.51 5.92 0.31 7.78e-9 Coronary artery disease; LUSC cis rs17102423 0.594 rs4902360 chr14:65546722 A/C cg11161011 chr14:65562177 MAX -0.72 -11.23 -0.52 4.71e-25 Obesity-related traits; LUSC cis rs4930103 1.000 rs4929983 chr11:2024579 C/T cg23202291 chr11:1979235 NA 0.41 6.34 0.33 7.46e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs2204008 0.557 rs11520191 chr12:38197057 T/A cg06521331 chr12:34319734 NA -0.4 -6.13 -0.32 2.51e-9 Bladder cancer; LUSC trans rs1005277 0.602 rs2504142 chr10:38383793 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.57 -0.46 2.51e-19 Extrinsic epigenetic age acceleration; LUSC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs611744 0.608 rs1448152 chr8:109278249 C/T cg18478394 chr8:109455254 TTC35 0.42 6.53 0.34 2.38e-10 Dupuytren's disease; LUSC cis rs9625935 0.843 rs41172 chr22:30422865 T/C cg11564601 chr22:30592435 NA -0.37 -5.84 -0.3 1.21e-8 Tonsillectomy; LUSC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.8 0.35 4.77e-11 Lung cancer; LUSC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.74 -0.39 1.18e-13 Aortic root size; LUSC cis rs4363385 0.647 rs7548977 chr1:152987365 T/G cg25856811 chr1:152973957 SPRR3 -0.38 -6.13 -0.32 2.54e-9 Inflammatory skin disease; LUSC cis rs1371867 0.875 rs1371868 chr8:101330267 C/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs11971779 0.666 rs7786851 chr7:139007020 C/G cg07862535 chr7:139043722 LUC7L2 -0.56 -6.27 -0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7804356 1.000 rs12539719 chr7:26844852 A/T cg03456212 chr7:26904342 SKAP2 -0.56 -6.55 -0.34 2.2e-10 Type 1 diabetes; LUSC cis rs73206853 0.563 rs80044246 chr12:111133535 C/A cg12870014 chr12:110450643 ANKRD13A 0.67 7.36 0.37 1.45e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.37 0.53 1.58e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1728785 0.901 rs6499186 chr16:68660565 C/T cg02972257 chr16:68554789 NA -0.53 -6.37 -0.33 6.25e-10 Ulcerative colitis; LUSC cis rs1670533 1.000 rs2045068 chr4:1052212 G/A cg16405210 chr4:1374714 KIAA1530 -0.48 -6.0 -0.31 5.02e-9 Recombination rate (females); LUSC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.13e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6687430 0.526 rs6688558 chr1:10611403 A/G cg17425144 chr1:10567563 PEX14 0.6 11.67 0.54 1.29e-26 Hand grip strength; LUSC cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.17 -0.37 4.9e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg22800045 chr5:56110881 MAP3K1 0.8 10.13 0.48 3.29e-21 Initial pursuit acceleration; LUSC cis rs35771425 0.509 rs3120782 chr1:211419700 A/T cg25617285 chr1:211431773 RCOR3 -0.38 -5.74 -0.3 2.08e-8 Educational attainment (years of education); LUSC cis rs9905704 0.633 rs2680697 chr17:56478711 T/A cg12560992 chr17:57184187 TRIM37 -0.46 -5.65 -0.3 3.52e-8 Testicular germ cell tumor; LUSC cis rs9325144 0.647 rs11168819 chr12:39011082 C/A cg13010199 chr12:38710504 ALG10B -0.52 -7.91 -0.4 3.77e-14 Morning vs. evening chronotype; LUSC cis rs7223966 1.000 rs6504170 chr17:61709168 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 7.09 0.36 7.84e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg04369109 chr6:150039330 LATS1 -0.52 -7.5 -0.38 5.95e-13 Lung cancer; LUSC cis rs7267979 0.932 rs6107052 chr20:25530838 G/A cg03522245 chr20:25566470 NINL 0.37 5.96 0.31 6.45e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg12463550 chr7:65579703 CRCP 0.5 7.03 0.36 1.17e-11 Aortic root size; LUSC cis rs9905704 0.846 rs35082135 chr17:56939694 A/G cg12560992 chr17:57184187 TRIM37 0.6 8.56 0.42 4.06e-16 Testicular germ cell tumor; LUSC cis rs7937890 0.904 rs67623158 chr11:14295196 T/C cg22961513 chr11:14280813 SPON1 0.34 5.73 0.3 2.29e-8 Mitochondrial DNA levels; LUSC cis rs2479724 1.000 rs1536703 chr6:41852755 C/T cg17623882 chr6:41773611 USP49 -0.59 -9.81 -0.47 4.11e-20 Menarche (age at onset); LUSC cis rs4700695 0.841 rs153367 chr5:65419170 G/A cg21114390 chr5:65439923 SFRS12 -0.47 -5.7 -0.3 2.6e-8 Facial morphology (factor 19); LUSC cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg26597838 chr10:835615 NA 0.64 8.08 0.4 1.21e-14 Eosinophil percentage of granulocytes; LUSC cis rs78456975 1.000 rs13400784 chr2:1564473 T/A cg01028140 chr2:1542097 TPO -0.61 -8.28 -0.41 2.96e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg11266682 chr4:10021025 SLC2A9 0.46 8.18 0.41 6.14e-15 Bone mineral density; LUSC cis rs10791097 0.694 rs12361892 chr11:130744490 T/G cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26918957 chr8:22926800 TNFRSF10B 0.38 5.94 0.31 7.02e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg00784671 chr22:46762841 CELSR1 -0.49 -6.67 -0.34 1.04e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1185460 0.967 rs3825061 chr11:118944675 C/T cg01677386 chr11:118938358 VPS11 -0.48 -6.46 -0.33 3.62e-10 Coronary artery disease; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg02018176 chr4:1364513 KIAA1530 0.51 8.73 0.43 1.2e-16 Obesity-related traits; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg08888203 chr3:10149979 C3orf24 0.69 9.25 0.45 2.66e-18 Alzheimer's disease; LUSC trans rs7944735 0.517 rs11039520 chr11:48130794 A/G cg03929089 chr4:120376271 NA 0.67 6.13 0.32 2.52e-9 Intraocular pressure; LUSC cis rs7772486 0.776 rs4316025 chr6:146238032 C/T cg05347473 chr6:146136440 FBXO30 -0.48 -8.2 -0.41 5.16e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg16049864 chr8:95962084 TP53INP1 -0.65 -12.61 -0.57 4.44e-30 Type 2 diabetes; LUSC cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg09307838 chr4:120376055 NA 0.78 11.23 0.52 4.68e-25 Corneal astigmatism; LUSC cis rs834603 0.575 rs834592 chr7:47474328 T/C cg09696706 chr7:47479511 TNS3 0.33 6.01 0.31 4.93e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18099408 chr3:52552593 STAB1 -0.4 -7.03 -0.36 1.19e-11 Electroencephalogram traits; LUSC cis rs79349575 0.715 rs55724082 chr17:47017879 G/A cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs55665837 1.000 rs10832256 chr11:14442875 G/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs9902453 0.967 rs17825877 chr17:28515188 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.79 0.43 8.12e-17 Coffee consumption (cups per day); LUSC trans rs9951602 0.512 rs1599636 chr18:76643916 G/A cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.34e-8 Diabetic kidney disease; LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02018176 chr4:1364513 KIAA1530 0.72 13.9 0.61 5.85e-35 Longevity; LUSC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg14784868 chr12:69753453 YEATS4 -0.68 -11.25 -0.52 4.15e-25 Blood protein levels; LUSC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg04455712 chr21:45112962 RRP1B 0.43 8.13 0.41 8.46e-15 Mean corpuscular volume; LUSC cis rs17253792 0.822 rs118027213 chr14:56039076 T/C cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg13390004 chr1:15929781 NA 0.41 7.12 0.36 6.8e-12 Systolic blood pressure; LUSC cis rs1538970 0.962 rs9429075 chr1:45818421 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.8 0.3 1.52e-8 Platelet count; LUSC trans rs208520 0.690 rs1351867 chr6:66760995 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 16.76 0.68 3.52e-46 Exhaled nitric oxide output; LUSC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg13206674 chr6:150067644 NUP43 0.6 9.5 0.46 4.09e-19 Lung cancer; LUSC cis rs8060686 0.545 rs12598630 chr16:68258852 T/G cg27539214 chr16:67997921 SLC12A4 -0.57 -7.02 -0.36 1.23e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs17253792 0.822 rs78615025 chr14:56168012 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.09e-12 Putamen volume; LUSC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 8.07 0.4 1.32e-14 Personality dimensions; LUSC cis rs11122272 0.735 rs1076804 chr1:231498460 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.06 -0.48 5.69e-21 Hemoglobin concentration; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg00149659 chr3:10157352 C3orf10 0.99 14.53 0.62 2.01e-37 Alzheimer's disease; LUSC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg13683864 chr3:40499215 RPL14 -1.05 -18.25 -0.71 4.01e-52 Renal cell carcinoma; LUSC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg13395646 chr4:1353034 KIAA1530 -0.6 -9.51 -0.46 3.89e-19 Longevity; LUSC cis rs9300255 0.510 rs1727323 chr12:123698790 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.84 -0.39 6.1e-14 Blood metabolite levels; LUSC cis rs6963495 0.818 rs1721500 chr7:105219233 T/G cg19920283 chr7:105172520 RINT1 0.61 6.48 0.33 3.26e-10 Bipolar disorder (body mass index interaction); LUSC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.88 -0.35 2.94e-11 Monocyte percentage of white cells; LUSC cis rs9914988 0.887 rs34644886 chr17:27168327 T/C cg09479241 chr17:27052676 TLCD1 0.42 5.79 0.3 1.64e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs662064 0.926 rs589400 chr1:10561282 A/G cg20482658 chr1:10539492 PEX14 0.34 6.85 0.35 3.47e-11 Asthma; LUSC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg25258033 chr6:167368657 RNASET2 0.44 7.02 0.36 1.25e-11 Crohn's disease; LUSC cis rs2219968 0.669 rs10099742 chr8:78871804 C/G cg00738934 chr8:78996279 NA -0.38 -6.74 -0.35 7.11e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.73 0.35 7.56e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg24531977 chr5:56204891 C5orf35 0.62 9.3 0.45 1.94e-18 Coronary artery disease; LUSC trans rs747782 0.527 rs2270993 chr11:48145166 G/A cg15704280 chr7:45808275 SEPT13 0.71 6.42 0.33 4.6e-10 Intraocular pressure; LUSC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC cis rs2274273 1.000 rs6573006 chr14:55610432 T/C cg04306507 chr14:55594613 LGALS3 0.57 13.17 0.58 3.46e-32 Protein biomarker; LUSC trans rs629535 0.821 rs650267 chr8:70029160 C/T cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs8017423 0.967 rs8016385 chr14:90721946 G/A cg04374321 chr14:90722782 PSMC1 0.75 12.12 0.55 2.92e-28 Mortality in heart failure; LUSC cis rs6690583 0.573 rs75119114 chr1:85451385 A/C cg22153463 chr1:85462885 MCOLN2 0.63 6.02 0.31 4.49e-9 Serum sulfate level; LUSC cis rs4660531 1.000 rs4660532 chr1:41840197 C/T cg08462924 chr1:41848221 NA 0.43 6.6 0.34 1.61e-10 Bipolar disorder; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 6.96 0.36 1.85e-11 Calcium levels; LUSC trans rs1325195 0.920 rs2636280 chr1:179156375 A/C cg11624085 chr17:8464688 MYH10 0.4 6.53 0.34 2.44e-10 IgE grass sensitization; LUSC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.54 -0.34 2.34e-10 Schizophrenia; LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg18404041 chr3:52824283 ITIH1 0.57 10.92 0.51 6.02e-24 Bipolar disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg02397499 chr11:61891354 INCENP -0.5 -6.81 -0.35 4.61e-11 Hepatitis; LUSC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg04871131 chr7:94954202 PON1 -0.38 -6.05 -0.31 3.93e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9906944 0.585 rs11650936 chr17:47072261 C/G cg14634687 chr17:47094252 IGF2BP1 -0.26 -6.0 -0.31 5.1e-9 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs7927771 0.524 rs7111576 chr11:47787445 G/A cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs5769707 0.967 rs9616713 chr22:50049109 G/A cg01652190 chr22:50026171 C22orf34 -0.31 -6.39 -0.33 5.6e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9902453 1.000 rs12600993 chr17:28291222 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.62 0.43 2.78e-16 Coffee consumption (cups per day); LUSC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg22590775 chr19:49891494 CCDC155 0.49 6.8 0.35 4.87e-11 Multiple sclerosis; LUSC cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg24112000 chr20:60950667 NA -0.46 -8.84 -0.44 5.57e-17 Colorectal cancer; LUSC cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg24642439 chr20:33292090 TP53INP2 0.73 11.86 0.54 2.48e-27 Coronary artery disease; LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg21782813 chr7:2030301 MAD1L1 0.43 7.05 0.36 1.03e-11 Bipolar disorder and schizophrenia; LUSC cis rs1003719 0.762 rs8130846 chr21:38480242 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.1 0.52 1.35e-24 Eye color traits; LUSC cis rs2204008 0.659 rs4002655 chr12:38169881 T/G cg26384229 chr12:38710491 ALG10B 0.9 15.55 0.65 2.12e-41 Bladder cancer; LUSC cis rs738321 0.711 rs5995541 chr22:38553411 C/T cg25457927 chr22:38595422 NA -0.39 -7.35 -0.37 1.54e-12 Breast cancer; LUSC cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg24642439 chr20:33292090 TP53INP2 0.5 7.58 0.38 3.46e-13 Glomerular filtration rate (creatinine); LUSC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg06618935 chr21:46677482 NA -0.37 -7.59 -0.38 3.25e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.73 -0.35 7.53e-11 Neuroticism; LUSC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg03433033 chr1:76189801 ACADM -0.74 -9.73 -0.47 7.14e-20 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg23422044 chr7:1970798 MAD1L1 -0.54 -5.79 -0.3 1.63e-8 Bipolar disorder; LUSC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.79 -0.47 4.46e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs10740039 0.768 rs10761549 chr10:62461660 A/G cg18175470 chr10:62150864 ANK3 -0.43 -6.64 -0.34 1.28e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg21724239 chr8:58056113 NA 0.82 9.61 0.47 1.8e-19 Developmental language disorder (linguistic errors); LUSC cis rs1153858 1.000 rs1049508 chr15:45653592 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.31 0.41 2.49e-15 Homoarginine levels; LUSC cis rs16937 0.662 rs10900464 chr1:205157100 T/C cg00857998 chr1:205179979 DSTYK 0.46 6.45 0.33 4e-10 Schizophrenia; LUSC cis rs909341 0.710 rs6010998 chr20:62294402 A/T cg16989086 chr20:62203971 PRIC285 -0.53 -7.38 -0.37 1.26e-12 Atopic dermatitis; LUSC cis rs4766646 0.757 rs4766641 chr12:110301492 T/A cg10794374 chr12:110278745 NA -0.31 -6.47 -0.33 3.45e-10 Metabolite levels (MHPG); LUSC cis rs9611519 1.000 rs6002271 chr22:41566595 C/T cg13813247 chr22:41461852 NA -0.36 -6.51 -0.34 2.83e-10 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17665931 chr19:38894173 FAM98C 0.39 6.01 0.31 4.82e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg25036284 chr2:26402008 FAM59B -0.73 -10.66 -0.5 4.85e-23 Gut microbiome composition (summer); LUSC cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg15839431 chr19:19639596 YJEFN3 -0.63 -7.15 -0.36 5.48e-12 Bipolar disorder; LUSC cis rs1881797 1.000 rs1881794 chr1:247682920 G/C cg14830002 chr1:247616686 OR2B11 -0.53 -8.1 -0.41 1.07e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs17789174 0.903 rs12597107 chr16:85070381 G/T cg01715842 chr16:85045600 ZDHHC7 -0.42 -5.8 -0.3 1.53e-8 Dysphagia; LUSC trans rs11992162 0.636 rs4841646 chr8:11798707 C/G cg06636001 chr8:8085503 FLJ10661 0.45 6.33 0.33 7.77e-10 Monocyte count; LUSC trans rs11098499 0.954 rs10006706 chr4:120409152 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.26 0.32 1.21e-9 Corneal astigmatism; LUSC cis rs6456156 0.524 rs6932740 chr6:167466439 G/A cg06454157 chr6:167490870 NA -0.28 -6.85 -0.35 3.67e-11 Primary biliary cholangitis; LUSC cis rs1775715 0.870 rs1775737 chr10:32256871 T/C cg03015672 chr10:32216066 ARHGAP12 0.33 5.7 0.3 2.58e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg19717773 chr7:2847554 GNA12 -0.4 -7.27 -0.37 2.61e-12 Height; LUSC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg25072359 chr17:41440525 NA -0.62 -9.23 -0.45 3.21e-18 Menopause (age at onset); LUSC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.59 0.34 1.69e-10 Systemic lupus erythematosus; LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg26314531 chr2:26401878 FAM59B -0.68 -8.97 -0.44 2.21e-17 Gut microbiome composition (summer); LUSC cis rs27434 0.607 rs34753 chr5:96150911 C/T cg16492584 chr5:96139282 ERAP1 -0.56 -7.67 -0.39 1.88e-13 Ankylosing spondylitis; LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.69 -10.09 -0.48 4.37e-21 Systemic lupus erythematosus; LUSC cis rs2147959 0.825 rs12746910 chr1:228658133 G/A cg18477163 chr1:228402036 OBSCN 0.41 5.65 0.3 3.39e-8 Adult asthma; LUSC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg13918804 chr1:2043761 PRKCZ 0.27 5.82 0.3 1.41e-8 Height; LUSC cis rs7084921 0.608 rs7474634 chr10:101863410 A/C cg02250046 chr10:101825185 CPN1 0.34 6.31 0.33 8.61e-10 Bone mineral density; LUSC cis rs1472147 1.000 rs3736609 chr7:128509319 G/A cg00260937 chr7:128520193 KCP 0.46 6.04 0.31 4.15e-9 Calcium levels; LUSC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg13918804 chr1:2043761 PRKCZ 0.27 5.74 0.3 2.12e-8 Height; LUSC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg18225595 chr11:63971243 STIP1 0.63 10.83 0.51 1.23e-23 Platelet count; LUSC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg08684580 chr7:98029266 BAIAP2L1 0.44 8.04 0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg00745463 chr17:30367425 LRRC37B 0.79 8.83 0.44 5.9e-17 Hip circumference adjusted for BMI; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07630649 chr16:75600717 GABARAPL2 -0.38 -5.94 -0.31 7.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9888739 0.800 rs7200615 chr16:31337155 G/A cg15817542 chr16:31343056 ITGAM -0.52 -7.01 -0.36 1.34e-11 Systemic lupus erythematosus; LUSC cis rs59698941 0.943 rs997633 chr5:132219304 A/T cg02081065 chr5:132209139 LEAP2 -0.65 -6.76 -0.35 6.04e-11 Apolipoprotein A-IV levels; LUSC cis rs2637266 1.000 rs2637270 chr10:78336901 C/T cg18941641 chr10:78392320 NA 0.37 6.91 0.35 2.4e-11 Pulmonary function; LUSC cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg03517284 chr6:25882590 NA -0.52 -9.69 -0.47 9.99e-20 Blood metabolite levels; LUSC cis rs9300255 0.510 rs1790086 chr12:123672518 A/G cg13010344 chr12:123464640 ARL6IP4 -0.47 -6.43 -0.33 4.42e-10 Neutrophil percentage of white cells; LUSC cis rs11758351 0.587 rs16891466 chr6:26235737 G/A cg01420254 chr6:26195488 NA 0.65 7.24 0.37 3.03e-12 Gout;Renal underexcretion gout; LUSC trans rs561341 0.505 rs28708703 chr17:30386845 C/G cg27661571 chr11:113659931 NA -0.64 -7.53 -0.38 4.66e-13 Hip circumference adjusted for BMI; LUSC trans rs9929218 0.551 rs2281850 chr16:68718750 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -1.05 -25.92 -0.82 6.1e-82 Colorectal cancer; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg24846343 chr22:24311635 DDTL 0.68 15.09 0.64 1.4e-39 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6684514 1.000 rs12045339 chr1:156294211 C/T cg16558208 chr1:156270281 VHLL 0.36 5.8 0.3 1.58e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs3736594 0.513 rs76013440 chr2:27816315 G/A cg27432699 chr2:27873401 GPN1 0.66 8.64 0.43 2.45e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7829975 0.742 rs7832968 chr8:8652889 G/A cg15556689 chr8:8085844 FLJ10661 0.68 10.6 0.5 8.19e-23 Mood instability; LUSC cis rs9914988 0.887 rs11080072 chr17:27081160 G/T cg19789473 chr17:27170043 C17orf63 -0.29 -5.65 -0.3 3.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg18305652 chr10:134549665 INPP5A 0.39 6.78 0.35 5.58e-11 Migraine; LUSC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg08470875 chr2:26401718 FAM59B 0.69 8.48 0.42 7.18e-16 Gut microbiome composition (summer); LUSC cis rs9393777 0.588 rs6941920 chr6:26492149 C/T cg12292205 chr6:26970375 C6orf41 -0.62 -7.57 -0.38 3.56e-13 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.749 rs11991118 chr8:10939273 A/C cg15556689 chr8:8085844 FLJ10661 0.48 7.34 0.37 1.65e-12 Triglycerides; LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg00684032 chr4:1343700 KIAA1530 -0.36 -6.29 -0.33 1e-9 Obesity-related traits; LUSC cis rs8062405 0.690 rs62034351 chr16:28565489 G/A cg16576597 chr16:28551801 NUPR1 0.34 6.8 0.35 4.9e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1775715 0.870 rs1755072 chr10:32266642 A/G cg03015672 chr10:32216066 ARHGAP12 -0.33 -5.81 -0.3 1.44e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs8072100 0.688 rs12602134 chr17:45582136 C/G cg08085267 chr17:45401833 C17orf57 0.58 9.56 0.46 2.63e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs11722228 0.549 rs73212863 chr4:10104173 C/T cg26043149 chr18:55253948 FECH 0.98 14.97 0.63 4.11e-39 Gout;Urate levels;Serum uric acid levels; LUSC cis rs11098499 0.954 rs7687843 chr4:120421211 C/T cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.66 -0.34 1.15e-10 Monocyte percentage of white cells; LUSC cis rs2637266 0.783 rs846585 chr10:78494466 T/G cg18941641 chr10:78392320 NA 0.39 7.1 0.36 7.32e-12 Pulmonary function; LUSC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.62 10.72 0.51 3.07e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs61931739 0.635 rs1405025 chr12:33908491 C/T cg13010199 chr12:38710504 ALG10B 0.41 6.12 0.32 2.65e-9 Morning vs. evening chronotype; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg00024416 chr22:24240387 NA -0.34 -5.91 -0.31 8.55e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs8060686 0.668 rs2418739 chr16:68092850 G/C cg05110241 chr16:68378359 PRMT7 -0.45 -6.05 -0.31 3.96e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.1e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.23e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg09021430 chr5:549028 NA -0.55 -7.25 -0.37 2.95e-12 Lung disease severity in cystic fibrosis; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.11 0.45 7.69e-18 Prudent dietary pattern; LUSC cis rs11190604 1.000 rs7078799 chr10:102301447 G/A cg23241863 chr10:102295624 HIF1AN 0.47 5.65 0.3 3.41e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg13010199 chr12:38710504 ALG10B 0.68 11.02 0.52 2.8e-24 Heart rate; LUSC cis rs8040855 0.599 rs6496792 chr15:85725745 T/A cg04831495 chr15:85060580 GOLGA6L5 0.41 6.87 0.35 3.1e-11 Bulimia nervosa; LUSC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg03233332 chr7:66118400 NA -0.44 -6.28 -0.33 1.05e-9 Aortic root size; LUSC cis rs2717559 0.542 rs2717560 chr8:143881670 G/A cg17252645 chr8:143867129 LY6D -0.55 -10.43 -0.5 3.02e-22 Urinary tract infection frequency; LUSC trans rs62238980 0.614 rs78907591 chr22:32459673 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg26513180 chr16:89883248 FANCA 0.9 16.51 0.67 3.45e-45 Vitiligo; LUSC cis rs9393777 0.528 rs9467989 chr6:27064275 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.36 -6.13 -0.32 2.42e-9 Intelligence (multi-trait analysis); LUSC cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg06784218 chr1:46089804 CCDC17 0.5 10.14 0.49 3.03e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7512552 0.809 rs2794685 chr1:150312268 C/T cg15654264 chr1:150340011 RPRD2 0.68 11.51 0.53 4.95e-26 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs8060686 0.641 rs73598006 chr16:68074454 C/G cg27539214 chr16:67997921 SLC12A4 -0.55 -7.52 -0.38 5.26e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.9 0.77 1.58e-66 Prudent dietary pattern; LUSC cis rs2677744 0.688 rs7183098 chr15:91452294 A/G cg23684204 chr15:91497937 RCCD1 0.44 6.13 0.32 2.47e-9 Attention deficit hyperactivity disorder; LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg21724239 chr8:58056113 NA 0.77 8.37 0.42 1.55e-15 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg13390004 chr1:15929781 NA 0.42 6.86 0.35 3.25e-11 Systolic blood pressure; LUSC cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg17892150 chr10:133769511 PPP2R2D 0.64 9.27 0.45 2.42e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.47 6.15 0.32 2.21e-9 Renal function-related traits (BUN); LUSC cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.92 0.44 3.2e-17 Motion sickness; LUSC cis rs6542838 0.646 rs17756034 chr2:99382810 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.49 -0.33 3.01e-10 Fear of minor pain; LUSC cis rs1506636 0.962 rs2456551 chr7:123394610 C/G cg03229431 chr7:123269106 ASB15 0.65 10.78 0.51 1.82e-23 Plateletcrit;Platelet count; LUSC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg20203395 chr5:56204925 C5orf35 -0.78 -10.61 -0.5 7.52e-23 Initial pursuit acceleration; LUSC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg06287003 chr12:125626642 AACS -0.39 -6.39 -0.33 5.71e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg15448220 chr1:150897856 SETDB1 0.41 5.91 0.31 8.67e-9 Melanoma; LUSC cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg14582100 chr15:45693742 SPATA5L1 0.59 10.69 0.5 4.01e-23 Homoarginine levels; LUSC cis rs4595586 0.545 rs67985200 chr12:39386891 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.36 0.37 1.42e-12 Morning vs. evening chronotype; LUSC cis rs1799949 0.602 rs8176199 chr17:41230524 T/G cg23758822 chr17:41437982 NA 1.01 15.0 0.63 3.04e-39 Menopause (age at onset); LUSC trans rs12692738 0.526 rs355869 chr2:165631397 C/T cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs78456975 1.000 rs6720874 chr2:1580504 A/G cg01028140 chr2:1542097 TPO -0.48 -6.8 -0.35 4.94e-11 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs763121 0.925 rs5757165 chr22:38994577 C/T cg06544989 chr22:39130855 UNC84B 0.36 6.59 0.34 1.67e-10 Menopause (age at onset); LUSC cis rs9303401 0.659 rs66514313 chr17:56714057 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.55e-35 Cognitive test performance; LUSC cis rs11168351 0.517 rs10875754 chr12:48557922 G/C cg24011408 chr12:48396354 COL2A1 0.52 8.64 0.43 2.3e-16 Bipolar disorder and schizophrenia; LUSC cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg03146154 chr1:46216737 IPP -0.55 -8.13 -0.41 8.57e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6484504 0.779 rs16921914 chr11:31210771 G/A cg14844989 chr11:31128820 NA -0.47 -6.74 -0.35 7.15e-11 Red blood cell count; LUSC cis rs11997175 0.603 rs7464072 chr8:33776973 G/A ch.8.33884649F chr8:33765107 NA 0.48 7.29 0.37 2.23e-12 Body mass index; LUSC cis rs7582180 0.613 rs12988464 chr2:100946285 A/G cg12002119 chr2:101014098 CHST10 0.35 5.94 0.31 6.99e-9 Intelligence (multi-trait analysis); LUSC trans rs3785574 0.962 rs62077509 chr17:61848973 A/G cg09060275 chr22:27053596 MIAT -0.4 -6.03 -0.31 4.45e-9 Height; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg22907277 chr7:1156413 C7orf50 0.45 6.9 0.35 2.7e-11 Longevity;Endometriosis; LUSC cis rs3126085 0.935 rs1552993 chr1:152171483 A/G cg03465714 chr1:152285911 FLG -0.4 -5.75 -0.3 2.05e-8 Atopic dermatitis; LUSC cis rs738321 0.757 rs4820314 chr22:38518538 G/A cg25457927 chr22:38595422 NA -0.37 -7.11 -0.36 7.29e-12 Breast cancer; LUSC cis rs7615952 0.736 rs13063122 chr3:125643860 G/A cg05084668 chr3:125655381 ALG1L -0.74 -11.37 -0.53 1.55e-25 Blood pressure (smoking interaction); LUSC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg12257692 chr3:49977190 RBM6 -0.25 -6.79 -0.35 5.24e-11 Intelligence (multi-trait analysis); LUSC cis rs7719624 1.000 rs2282791 chr5:135377730 T/G cg12897067 chr5:135418308 NA 0.42 6.11 0.32 2.72e-9 Response to cytidine analogues (gemcitabine); LUSC cis rs4815879 0.509 rs4815883 chr20:6040283 C/T cg25325723 chr20:6104886 FERMT1 -0.52 -6.17 -0.32 1.94e-9 Preeclampsia; LUSC cis rs4268898 0.610 rs34216622 chr2:24463445 G/C cg06627628 chr2:24431161 ITSN2 -0.87 -12.73 -0.57 1.52e-30 Asthma; LUSC trans rs7615952 0.512 rs1077621 chr3:125819799 A/G cg07211511 chr3:129823064 LOC729375 -0.75 -9.7 -0.47 9.15e-20 Blood pressure (smoking interaction); LUSC cis rs7568458 0.870 rs1058588 chr2:85808871 A/G cg17127132 chr2:85788382 GGCX -0.47 -7.57 -0.38 3.71e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg10224037 chr5:178157518 ZNF354A 0.64 8.58 0.43 3.59e-16 Neutrophil percentage of white cells; LUSC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg04455712 chr21:45112962 RRP1B -0.51 -9.87 -0.48 2.53e-20 Mean corpuscular volume; LUSC cis rs2486288 0.656 rs10519018 chr15:45549265 C/T cg09092052 chr15:45571596 NA 0.47 6.67 0.34 1.09e-10 Glomerular filtration rate; LUSC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg06494592 chr3:125709126 NA -0.5 -5.73 -0.3 2.24e-8 Blood pressure (smoking interaction); LUSC cis rs2963155 0.518 rs864355 chr5:142633229 A/G cg17617527 chr5:142782415 NR3C1 0.71 8.42 0.42 1.14e-15 Breast cancer; LUSC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg08392591 chr16:89556376 ANKRD11 0.45 6.69 0.34 9.38e-11 Multiple myeloma (IgH translocation); LUSC cis rs3740713 1.000 rs73440625 chr11:18470800 A/G cg23797887 chr11:18477753 LDHAL6A -0.56 -6.77 -0.35 5.8e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7927592 0.913 rs11228268 chr11:68287447 A/T cg20283391 chr11:68216788 NA -0.61 -8.55 -0.42 4.43e-16 Total body bone mineral density; LUSC cis rs11168618 0.875 rs11458 chr12:48888594 C/T cg24011408 chr12:48396354 COL2A1 0.4 6.28 0.33 1.04e-9 Adiponectin levels; LUSC cis rs9403521 0.580 rs9376772 chr6:143960454 T/C cg18240653 chr6:144019428 PHACTR2 -0.51 -5.75 -0.3 2.06e-8 Obesity-related traits; LUSC cis rs908922 0.887 rs1415432 chr1:152480654 G/A cg20991723 chr1:152506922 NA 0.53 8.84 0.44 5.62e-17 Hair morphology; LUSC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg19717773 chr7:2847554 GNA12 -0.35 -6.0 -0.31 5.27e-9 Height; LUSC cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.27 0.45 2.34e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs3806843 1.000 rs2098058 chr5:140157427 A/C cg19875535 chr5:140030758 IK -0.47 -7.79 -0.39 8.34e-14 Depressive symptoms (multi-trait analysis); LUSC trans rs7618501 0.633 rs9866695 chr3:50069452 G/T cg21659725 chr3:3221576 CRBN -0.65 -10.79 -0.51 1.73e-23 Intelligence (multi-trait analysis); LUSC cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg22349387 chr12:9600060 DDX12 -0.43 -6.99 -0.36 1.49e-11 Breast size; LUSC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7589342 0.831 rs11124062 chr2:106455967 G/A cg14210321 chr2:106509881 NCK2 -0.54 -8.06 -0.4 1.35e-14 Addiction; LUSC cis rs13256369 0.865 rs13277708 chr8:8573936 T/C cg18904891 chr8:8559673 CLDN23 0.55 7.67 0.39 1.85e-13 Obesity-related traits; LUSC cis rs2486288 0.656 rs8039352 chr15:45551790 A/G cg09092052 chr15:45571596 NA 0.43 5.96 0.31 6.56e-9 Glomerular filtration rate; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg08088566 chr11:430123 ANO9 0.73 8.04 0.4 1.55e-14 Body mass index; LUSC cis rs8114671 0.967 rs6142323 chr20:33788983 A/G cg07148914 chr20:33460835 GGT7 -0.44 -6.51 -0.34 2.74e-10 Height; LUSC cis rs6076065 0.723 rs2424548 chr20:23394456 A/C cg11657817 chr20:23433608 CST11 0.43 8.16 0.41 6.81e-15 Facial morphology (factor 15, philtrum width); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12187437 chr12:66524584 LLPH 0.43 6.19 0.32 1.76e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17095355 1.000 rs13377046 chr10:111729228 T/A cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.42 -0.38 1.01e-12 Biliary atresia; LUSC cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg12463550 chr7:65579703 CRCP 0.47 6.74 0.35 6.77e-11 Aortic root size; LUSC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg15145296 chr3:125709740 NA -0.56 -6.65 -0.34 1.22e-10 Blood pressure (smoking interaction); LUSC cis rs11098499 0.863 rs3775848 chr4:120447724 C/T cg24375607 chr4:120327624 NA 0.76 11.14 0.52 1e-24 Corneal astigmatism; LUSC cis rs9815354 0.812 rs17217536 chr3:41923300 A/C cg03022575 chr3:42003672 ULK4 0.83 8.57 0.42 3.85e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg14004847 chr7:1930337 MAD1L1 0.54 8.46 0.42 8.35e-16 Bipolar disorder and schizophrenia; LUSC cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg05714579 chr10:131428358 MGMT 0.46 6.56 0.34 2e-10 Response to temozolomide; LUSC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC trans rs561341 1.000 rs546519 chr17:30297682 T/G cg20587970 chr11:113659929 NA -1.11 -15.3 -0.64 1.99e-40 Hip circumference adjusted for BMI; LUSC cis rs12940923 0.872 rs59775965 chr17:56370439 T/C cg19466818 chr17:56409534 MIR142 -0.38 -6.76 -0.35 6.25e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs62400317 0.821 rs12206568 chr6:45152747 C/T cg18551225 chr6:44695536 NA -0.42 -6.89 -0.35 2.85e-11 Total body bone mineral density; LUSC cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg15839431 chr19:19639596 YJEFN3 0.64 6.99 0.36 1.5e-11 Bipolar disorder; LUSC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg21138405 chr5:131827807 IRF1 -0.35 -6.24 -0.32 1.31e-9 Breast cancer;Mosquito bite size; LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg11843238 chr5:131593191 PDLIM4 -0.35 -6.14 -0.32 2.41e-9 Breast cancer; LUSC cis rs10752881 0.935 rs10911235 chr1:183053746 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Colorectal cancer; LUSC cis rs2742417 1.000 rs2742389 chr3:45756683 G/C cg18779283 chr3:45636154 LIMD1 -0.34 -5.9 -0.31 8.79e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4604732 0.642 rs4489599 chr1:247635213 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.34 -5.74 -0.3 2.17e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs524023 0.874 rs7102344 chr11:64396569 A/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.37 -0.49 4.89e-22 Urate levels in obese individuals; LUSC cis rs4595586 0.655 rs11170269 chr12:39387077 G/A cg26384229 chr12:38710491 ALG10B 0.42 5.8 0.3 1.56e-8 Morning vs. evening chronotype; LUSC cis rs6692729 0.933 rs1794038 chr1:227073712 T/G cg10327440 chr1:227177885 CDC42BPA -0.49 -6.9 -0.35 2.57e-11 Electrodermal activity; LUSC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg22442454 chr1:209979470 IRF6 0.43 5.88 0.31 9.86e-9 Cleft lip with or without cleft palate; LUSC cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg27170947 chr2:26402098 FAM59B -0.64 -9.34 -0.46 1.35e-18 Gut microbiome composition (summer); LUSC trans rs2151145 0.823 rs1930259 chr9:82314409 A/G cg21119293 chr14:104621601 KIF26A -0.3 -5.98 -0.31 5.6e-9 Menopause (age at onset); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg05670192 chr19:56154902 ZNF581 0.4 6.26 0.32 1.2e-9 Calcium levels; LUSC cis rs7953508 0.750 rs7310512 chr12:93976703 C/T cg18151635 chr12:93972918 NA -0.56 -7.98 -0.4 2.32e-14 Pubertal anthropometrics; LUSC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs9581857 0.685 rs9319371 chr13:28042564 A/G cg22138327 chr13:27999177 GTF3A 0.74 8.04 0.4 1.53e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs703842 0.575 rs701006 chr12:58106836 C/T cg15848620 chr12:58087721 OS9 0.47 6.89 0.35 2.86e-11 Multiple sclerosis; LUSC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg05347473 chr6:146136440 FBXO30 -0.58 -10.02 -0.48 7.55e-21 Lobe attachment (rater-scored or self-reported); LUSC trans rs60843830 0.661 rs62116681 chr2:104197 A/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.52 8.01 0.4 1.99e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7586879 0.639 rs4077678 chr2:25122840 C/G cg15423357 chr2:25149977 NA 0.44 8.97 0.44 2.13e-17 Body mass index; LUSC cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -6.99 -0.36 1.5e-11 Bipolar disorder; LUSC cis rs4631830 0.900 rs10763546 chr10:51536399 C/G cg20129853 chr10:51489980 NA -0.34 -6.91 -0.35 2.45e-11 Prostate-specific antigen levels; LUSC cis rs10170310 0.938 rs11680891 chr2:139264454 T/G cg03782584 chr2:139258740 SPOPL 0.34 5.92 0.31 7.97e-9 Response to antipsychotic treatment; LUSC cis rs7681440 0.869 rs894280 chr4:90760883 C/T cg20003494 chr4:90757398 SNCA -0.34 -5.86 -0.31 1.13e-8 Dementia with Lewy bodies; LUSC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC cis rs11864453 0.612 rs11862813 chr16:72132356 C/T cg16558253 chr16:72132732 DHX38 -0.37 -5.92 -0.31 8.15e-9 Fibrinogen levels; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg25767906 chr1:53392781 SCP2 -0.54 -10.54 -0.5 1.27e-22 Monocyte count; LUSC cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg06784218 chr1:46089804 CCDC17 0.53 10.49 0.5 1.9e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg14773178 chr5:1868261 NA 0.33 6.03 0.31 4.33e-9 Cardiovascular disease risk factors; LUSC cis rs12973672 0.812 rs2280745 chr19:35756178 T/C cg12095397 chr19:35769544 USF2 0.41 6.1 0.32 3.01e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4478858 0.684 rs4949372 chr1:31738857 G/A cg00250761 chr1:31883323 NA -0.34 -8.19 -0.41 5.53e-15 Alcohol dependence; LUSC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg00376283 chr12:123451042 ABCB9 0.76 12.01 0.55 7.33e-28 Platelet count; LUSC cis rs2455601 0.882 rs10840139 chr11:8894838 T/G cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -8.42 -0.42 1.09e-15 Schizophrenia; LUSC cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg16586182 chr3:47516702 SCAP -0.51 -7.91 -0.4 3.91e-14 Colorectal cancer; LUSC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg09365446 chr1:150670422 GOLPH3L 0.54 7.82 0.39 7.08e-14 Melanoma; LUSC cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg21427119 chr20:30132790 HM13 -0.42 -6.28 -0.33 1.05e-9 Mean corpuscular hemoglobin; LUSC cis rs1163251 0.902 rs639761 chr1:120217558 G/A cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC cis rs950027 0.620 rs1153857 chr15:45659095 G/T cg21132104 chr15:45694354 SPATA5L1 0.42 6.13 0.32 2.45e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs6429082 0.715 rs9793740 chr1:235595590 T/C cg26050004 chr1:235667680 B3GALNT2 -0.54 -7.59 -0.38 3.25e-13 Adiposity; LUSC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg21699342 chr2:239360505 ASB1 0.56 10.41 0.49 3.78e-22 Multiple system atrophy; LUSC cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg12863693 chr15:85201151 NMB 0.39 8.08 0.4 1.19e-14 Schizophrenia; LUSC trans rs6561151 0.681 rs10507521 chr13:44441834 C/G cg12856521 chr11:46389249 DGKZ -0.76 -10.12 -0.48 3.6e-21 Crohn's disease; LUSC cis rs1983170 0.808 rs2893176 chr1:92017684 A/C cg25838465 chr1:92012736 NA 0.42 5.82 0.3 1.4e-8 Eosinophil percentage of white cells; LUSC cis rs11711311 0.747 rs7638378 chr3:113343630 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.97 -0.31 6.16e-9 IgG glycosylation; LUSC cis rs11583043 0.708 rs12754497 chr1:101571888 A/G cg11406453 chr1:101602562 NA 0.4 6.91 0.35 2.5e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg21724239 chr8:58056113 NA 0.55 6.61 0.34 1.48e-10 Developmental language disorder (linguistic errors); LUSC trans rs2797160 1.000 rs1777225 chr6:126018270 T/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.95 0.36 1.88e-11 Endometrial cancer; LUSC trans rs564343 0.545 rs576836 chr11:65823569 G/C cg26701943 chr11:108369231 KDELC2 -0.44 -6.02 -0.31 4.66e-9 Obesity (early onset extreme); LUSC cis rs12594515 1.000 rs6493176 chr15:45990026 A/G cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.42 -6.95 -0.36 1.98e-11 Neutrophil percentage of white cells; LUSC cis rs6460942 0.822 rs13340498 chr7:12233877 G/T cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs7119 0.717 rs10519167 chr15:77723027 G/T cg27398640 chr15:77910606 LINGO1 -0.28 -5.91 -0.31 8.58e-9 Type 2 diabetes; LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.37 0.37 1.34e-12 Prudent dietary pattern; LUSC cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg21918786 chr6:109611834 NA -0.4 -6.91 -0.35 2.49e-11 Reticulocyte fraction of red cells; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27451230 chr4:77870891 SEPT11 -0.48 -6.26 -0.32 1.18e-9 Bipolar disorder and schizophrenia; LUSC cis rs3845702 1.000 rs262279 chr2:180869145 G/A cg01881094 chr2:180872142 CWC22 0.8 10.29 0.49 9.18e-22 Schizophrenia; LUSC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg05585544 chr11:47624801 NA -0.43 -7.51 -0.38 5.31e-13 Subjective well-being; LUSC cis rs2029213 0.523 rs4687715 chr3:53269904 G/A cg16894138 chr3:53270350 TKT 0.34 7.3 0.37 2.12e-12 Heart rate; LUSC cis rs2067615 0.579 rs11113119 chr12:107200056 C/A cg15890332 chr12:107067104 RFX4 0.34 6.26 0.32 1.21e-9 Heart rate; LUSC trans rs11098499 0.863 rs7669520 chr4:120515278 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.68 0.34 9.88e-11 Corneal astigmatism; LUSC cis rs2108225 0.837 rs7810937 chr7:107447500 A/G cg18560240 chr7:107437656 SLC26A3 -0.45 -6.67 -0.34 1.06e-10 Ulcerative colitis; LUSC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg24733560 chr20:60626293 TAF4 0.39 6.31 0.33 8.99e-10 Body mass index; LUSC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg23788917 chr6:8435910 SLC35B3 0.48 7.11 0.36 7.03e-12 Motion sickness; LUSC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.49 -6.83 -0.35 3.92e-11 Tonsillectomy; LUSC cis rs6504249 0.893 rs2521827 chr17:62692728 T/G cg02598441 chr17:62777298 LOC146880 -0.56 -7.28 -0.37 2.48e-12 Joint mobility (Beighton score); LUSC trans rs75804782 0.641 rs6715311 chr2:239363321 A/G cg01134436 chr17:81009848 B3GNTL1 0.61 5.96 0.31 6.34e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg09034736 chr1:150693464 HORMAD1 0.49 7.16 0.36 5.33e-12 Tonsillectomy; LUSC cis rs13315871 0.929 rs1045115 chr3:58305199 C/T cg20936604 chr3:58311152 NA -0.65 -6.78 -0.35 5.4e-11 Cholesterol, total; LUSC cis rs17401966 0.867 rs12403443 chr1:10423988 A/G cg19773385 chr1:10388646 KIF1B -0.5 -7.57 -0.38 3.73e-13 Hepatocellular carcinoma; LUSC cis rs6840360 1.000 rs17360475 chr4:152671640 C/G cg22705602 chr4:152727874 NA 0.34 6.83 0.35 4.01e-11 Intelligence (multi-trait analysis); LUSC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg11752832 chr7:134001865 SLC35B4 0.59 9.06 0.44 1.1e-17 Mean platelet volume; LUSC trans rs1728785 1.000 rs1645928 chr16:68590610 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.64 8.21 0.41 4.86e-15 Ulcerative colitis; LUSC cis rs7267979 0.934 rs2261115 chr20:25259807 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.87 19.06 0.72 2.56e-55 Liver enzyme levels (alkaline phosphatase); LUSC trans rs72674100 0.867 rs75247520 chr4:97980121 C/T cg16405019 chr1:18959625 PAX7 -0.61 -6.0 -0.31 5.27e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg23262073 chr20:60523788 NA -0.42 -6.0 -0.31 5.03e-9 Body mass index; LUSC cis rs2413583 0.591 rs79605405 chr22:39696638 C/A cg17798944 chr22:39715225 SNORD43;RPL3 0.66 6.54 0.34 2.36e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs11971779 0.680 rs17691238 chr7:139052284 A/G cg23387468 chr7:139079360 LUC7L2 -0.39 -6.01 -0.31 4.84e-9 Diisocyanate-induced asthma; LUSC cis rs4363385 0.510 rs11590835 chr1:153047166 T/C cg00922841 chr1:152955080 SPRR1A -0.38 -6.35 -0.33 6.9e-10 Inflammatory skin disease; LUSC cis rs7523050 0.643 rs35885176 chr1:109401868 G/A cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs9300255 0.596 rs1568427 chr12:123738678 A/G cg00376283 chr12:123451042 ABCB9 0.67 9.37 0.46 1.12e-18 Neutrophil percentage of white cells; LUSC cis rs7267979 0.966 rs2263204 chr20:25377688 A/T cg03522245 chr20:25566470 NINL -0.35 -5.74 -0.3 2.18e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg03709012 chr19:19516395 GATAD2A -0.76 -11.95 -0.55 1.18e-27 Tonsillectomy; LUSC cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.44 6.62 0.34 1.47e-10 Systemic lupus erythematosus; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg12016809 chr21:47604291 C21orf56 -0.46 -6.97 -0.36 1.69e-11 Testicular germ cell tumor; LUSC cis rs317689 1.000 rs317689 chr12:69727190 G/A cg11871910 chr12:69753446 YEATS4 0.55 7.12 0.36 6.71e-12 Response to diuretic therapy; LUSC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg04539111 chr16:67997858 SLC12A4 -0.46 -6.16 -0.32 2.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2243480 1.000 rs1618893 chr7:66096119 C/T cg18252515 chr7:66147081 NA -1.02 -11.15 -0.52 9.24e-25 Diabetic kidney disease; LUSC cis rs1568889 0.641 rs34857148 chr11:28481976 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.53 6.64 0.34 1.28e-10 Bipolar disorder; LUSC cis rs6938 0.618 rs62029167 chr15:75228350 G/A cg03289416 chr15:75166202 SCAMP2 0.46 7.02 0.36 1.23e-11 Breast cancer; LUSC cis rs7100689 0.577 rs1417219 chr10:82041409 C/T cg01528321 chr10:82214614 TSPAN14 0.94 14.76 0.63 2.59e-38 Post bronchodilator FEV1; LUSC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs12682352 0.602 rs28399241 chr8:8663215 C/T cg18904891 chr8:8559673 CLDN23 0.42 6.05 0.31 3.9e-9 Neuroticism; LUSC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg00033643 chr7:134001901 SLC35B4 0.47 7.42 0.38 9.63e-13 Mean platelet volume; LUSC cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg01884057 chr2:25150051 NA 0.48 11.39 0.53 1.29e-25 Body mass index; LUSC cis rs6840360 0.571 rs11940881 chr4:152501050 C/G cg22705602 chr4:152727874 NA -0.32 -6.49 -0.33 3.07e-10 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 8.12e-16 Aortic root size; LUSC cis rs7605827 0.930 rs7578126 chr2:15522772 C/T cg19274914 chr2:15703543 NA 0.45 8.93 0.44 2.91e-17 Educational attainment (years of education); LUSC cis rs17253792 0.749 rs79713967 chr14:56124186 T/C cg01858014 chr14:56050164 KTN1 -0.8 -6.58 -0.34 1.79e-10 Putamen volume; LUSC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg22823121 chr1:150693482 HORMAD1 0.5 7.44 0.38 8.47e-13 Melanoma; LUSC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC trans rs61931739 0.500 rs11053261 chr12:34530810 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.72e-21 Monocyte count; LUSC trans rs7746199 0.736 rs34064842 chr6:27688625 G/T cg01620082 chr3:125678407 NA -0.78 -7.29 -0.37 2.28e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg21665744 chr7:39171113 POU6F2 0.43 6.51 0.34 2.82e-10 IgG glycosylation; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg13560548 chr3:10150139 C3orf24 0.54 7.11 0.36 7.09e-12 Alzheimer's disease; LUSC cis rs11168618 0.904 rs12371700 chr12:48919213 G/T cg24011408 chr12:48396354 COL2A1 -0.39 -6.22 -0.32 1.46e-9 Adiponectin levels; LUSC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg06238570 chr21:40685208 BRWD1 -0.56 -9.03 -0.44 1.37e-17 Menarche (age at onset); LUSC cis rs1113500 0.636 rs3853493 chr1:108637193 G/A cg06207961 chr1:108661230 NA 0.31 5.78 0.3 1.69e-8 Growth-regulated protein alpha levels; LUSC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs11711311 1.000 rs62268169 chr3:113493860 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.84 -0.3 1.24e-8 IgG glycosylation; LUSC cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs7267979 0.903 rs6132819 chr20:25218618 C/G cg08601574 chr20:25228251 PYGB 0.48 7.37 0.37 1.33e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2324229 0.789 rs1180197 chr6:83959124 C/T cg08257003 chr6:84140564 ME1 0.3 6.96 0.36 1.76e-11 Platelet-derived growth factor BB levels; LUSC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs7605827 0.930 rs2287263 chr2:15637366 C/T cg19274914 chr2:15703543 NA 0.45 8.51 0.42 5.89e-16 Educational attainment (years of education); LUSC trans rs1814175 0.935 rs7950947 chr11:49668369 C/T cg15704280 chr7:45808275 SEPT13 -1.09 -22.35 -0.77 2.54e-68 Height; LUSC cis rs7712401 0.601 rs36180885 chr5:122356403 C/A cg19077854 chr5:122220652 SNX24 -0.37 -7.58 -0.38 3.54e-13 Mean platelet volume; LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg22166914 chr1:53195759 ZYG11B -0.49 -7.7 -0.39 1.5700000000000001e-13 Monocyte count; LUSC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg15445000 chr17:37608096 MED1 0.38 6.69 0.34 9.58e-11 Glomerular filtration rate (creatinine); LUSC cis rs9747201 0.862 rs57596657 chr17:80147978 C/T cg18209359 chr17:80159595 CCDC57 -0.39 -6.66 -0.34 1.15e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg06636001 chr8:8085503 FLJ10661 -0.63 -9.83 -0.47 3.5e-20 Joint mobility (Beighton score); LUSC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg17264618 chr3:40429014 ENTPD3 0.32 6.83 0.35 3.96e-11 Renal cell carcinoma; LUSC cis rs11971779 0.638 rs77668044 chr7:139111085 T/A cg07862535 chr7:139043722 LUC7L2 0.7 7.58 0.38 3.5e-13 Diisocyanate-induced asthma; LUSC cis rs36093844 0.706 rs79814326 chr11:85585573 A/G cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs11098499 0.954 rs12499324 chr4:120393786 C/T cg24375607 chr4:120327624 NA 0.81 12.0 0.55 8.02e-28 Corneal astigmatism; LUSC cis rs4654899 1.000 rs3767248 chr1:21276854 A/G cg01072550 chr1:21505969 NA -0.56 -8.63 -0.43 2.5e-16 Superior frontal gyrus grey matter volume; LUSC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.67 0.47 1.12e-19 Height; LUSC cis rs4268898 0.662 rs2891382 chr2:24511491 C/G cg06627628 chr2:24431161 ITSN2 -0.85 -12.72 -0.57 1.7e-30 Asthma; LUSC cis rs9309473 0.904 rs62149783 chr2:73821384 T/A cg20560298 chr2:73613845 ALMS1 -0.44 -6.33 -0.33 7.94e-10 Metabolite levels; LUSC cis rs7000551 0.675 rs2443503 chr8:22381850 A/G cg12081754 chr8:22256438 SLC39A14 0.45 6.66 0.34 1.14e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg00898013 chr13:113819073 PROZ -0.52 -7.77 -0.39 9.57e-14 Platelet distribution width; LUSC cis rs4812048 0.793 rs62205397 chr20:57597011 C/T cg14073986 chr20:57617431 SLMO2 0.71 7.26 0.37 2.68e-12 Mean platelet volume; LUSC cis rs9581857 0.512 rs9581866 chr13:28063176 G/A cg22138327 chr13:27999177 GTF3A 0.81 8.37 0.42 1.61e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs965469 1.000 rs6037554 chr20:3315613 G/A cg25506879 chr20:3388711 C20orf194 -0.51 -5.68 -0.3 2.97e-8 IFN-related cytopenia; LUSC trans rs7824557 0.545 rs2736303 chr8:11236850 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.19e-14 Retinal vascular caliber; LUSC trans rs45509595 0.822 rs200484 chr6:27775674 A/G cg01620082 chr3:125678407 NA -0.69 -7.05 -0.36 1.06e-11 Breast cancer; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg05095774 chr18:52495848 RAB27B 0.49 6.07 0.32 3.52e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg08859206 chr1:53392774 SCP2 -0.7 -13.19 -0.59 3.01e-32 Monocyte count; LUSC cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg21535247 chr6:8435926 SLC35B3 0.58 9.13 0.45 6.72e-18 Motion sickness; LUSC cis rs897984 0.762 rs4889599 chr16:30968589 C/T cg02466173 chr16:30829666 NA 0.56 11.1 0.52 1.39e-24 Dementia with Lewy bodies; LUSC cis rs4319547 0.585 rs7952868 chr12:122846949 A/G cg23029597 chr12:123009494 RSRC2 -0.73 -9.1 -0.45 8.29e-18 Body mass index; LUSC cis rs1670533 1.000 rs10007978 chr4:1060984 A/T cg02018176 chr4:1364513 KIAA1530 0.43 5.85 0.3 1.16e-8 Recombination rate (females); LUSC cis rs7106204 0.686 rs12803800 chr11:24258319 A/G ch.11.24196551F chr11:24239977 NA 0.73 6.22 0.32 1.49e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1372520 0.627 rs2737025 chr4:90719192 A/G cg15133208 chr4:90757351 SNCA -0.55 -8.63 -0.43 2.6e-16 Neuroticism; LUSC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs8016982 0.657 rs11625861 chr14:81735001 C/T cg01989461 chr14:81687754 GTF2A1 -0.67 -11.79 -0.54 4.58e-27 Schizophrenia; LUSC cis rs11166629 1.000 rs6992668 chr8:135645129 T/C cg27224718 chr8:135614730 ZFAT 0.66 10.9 0.51 6.87e-24 Smoking quantity; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg08859206 chr1:53392774 SCP2 -0.57 -10.68 -0.5 4.36e-23 Monocyte count; LUSC cis rs4774899 0.837 rs12899904 chr15:57416843 A/T cg21617494 chr15:57618479 NA -0.36 -6.0 -0.31 5.18e-9 Urinary tract infection frequency; LUSC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2980439 0.557 rs2976876 chr8:8318850 T/C cg15556689 chr8:8085844 FLJ10661 0.68 11.09 0.52 1.56e-24 Neuroticism; LUSC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg11608241 chr8:8085544 FLJ10661 -0.4 -5.67 -0.3 3.11e-8 Mean corpuscular volume; LUSC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg05855489 chr10:104503620 C10orf26 -0.7 -10.43 -0.5 3.12e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12310956 0.510 rs10844694 chr12:33865682 A/C cg06521331 chr12:34319734 NA -0.38 -6.21 -0.32 1.57e-9 Morning vs. evening chronotype; LUSC cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg07636037 chr3:49044803 WDR6 0.64 8.29 0.41 2.8e-15 Menarche (age at onset); LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg08677398 chr8:58056175 NA 0.58 7.13 0.36 6.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg24675658 chr1:53192096 ZYG11B 0.59 9.22 0.45 3.51e-18 Monocyte count; LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg26314531 chr2:26401878 FAM59B 0.72 10.16 0.49 2.55e-21 Gut microbiome composition (summer); LUSC cis rs9790314 1.000 rs2218803 chr3:161047973 T/G cg04691961 chr3:161091175 C3orf57 -0.35 -5.94 -0.31 7.23e-9 Morning vs. evening chronotype; LUSC cis rs6980507 0.524 rs4568607 chr8:42364354 T/C cg09913449 chr8:42400586 C8orf40 -0.44 -7.67 -0.39 1.84e-13 Glycated hemoglobin levels; LUSC cis rs2742540 0.503 rs11042121 chr11:8932640 A/C cg12365402 chr11:9010492 NRIP3 0.4 6.83 0.35 4.06e-11 Hematocrit; LUSC cis rs7312933 0.584 rs6582391 chr12:42634686 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.92 0.35 2.25e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs3008870 0.959 rs2815353 chr1:67483372 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.31 0.64 1.87e-40 Lymphocyte percentage of white cells; LUSC cis rs10740039 1.000 rs10761545 chr10:62418569 C/T cg18175470 chr10:62150864 ANK3 -0.43 -6.8 -0.35 4.8e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs10432489 0.708 rs10189224 chr2:181764318 A/C cg11196870 chr8:41386826 GINS4 -0.91 -6.37 -0.33 6.21e-10 QT interval; LUSC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg13798780 chr7:105162888 PUS7 0.57 5.99 0.31 5.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1009647 0.583 rs72715746 chr14:55741370 G/A cg04306507 chr14:55594613 LGALS3 0.43 5.82 0.3 1.37e-8 Testicular germ cell tumor; LUSC cis rs8060686 0.920 rs12448923 chr16:67839128 C/T cg27539214 chr16:67997921 SLC12A4 -0.46 -5.93 -0.31 7.38e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg07936489 chr17:37558343 FBXL20 -0.71 -9.96 -0.48 1.21e-20 Glomerular filtration rate (creatinine); LUSC cis rs2204008 0.743 rs2132212 chr12:38039405 G/A cg26384229 chr12:38710491 ALG10B 0.8 13.36 0.59 6.6e-33 Bladder cancer; LUSC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg20295408 chr7:1910781 MAD1L1 -0.49 -6.82 -0.35 4.23e-11 Schizophrenia; LUSC cis rs977987 0.806 rs35552529 chr16:75405879 G/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.85 -0.35 3.49e-11 Dupuytren's disease; LUSC trans rs79976124 0.879 rs17432710 chr6:66621744 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.32 0.41 2.23e-15 Type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20566420 chr12:122327043 PSMD9 0.45 6.28 0.32 1.05e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7264396 0.887 rs6120954 chr20:34059536 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -5.85 -0.3 1.17e-8 Total cholesterol levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16689800 chr10:122216376 PPAPDC1A -0.5 -6.06 -0.31 3.63e-9 Bipolar disorder and schizophrenia; LUSC cis rs3849570 0.615 rs6766011 chr3:81986136 G/A cg07356753 chr3:81810745 GBE1 -0.42 -6.19 -0.32 1.73e-9 Waist circumference;Body mass index; LUSC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.86 11.47 0.53 6.92e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28595532 0.702 rs72670256 chr4:119391043 G/A cg02775129 chr4:119771670 NA -0.79 -6.58 -0.34 1.85e-10 Cannabis dependence symptom count; LUSC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg10207240 chr12:122356781 WDR66 -0.46 -6.82 -0.35 4.18e-11 Mean corpuscular volume; LUSC cis rs231513 0.871 rs231522 chr17:41954602 A/G cg26893861 chr17:41843967 DUSP3 -0.53 -5.84 -0.3 1.26e-8 Cognitive function; LUSC cis rs4851254 0.550 rs13402289 chr2:100659389 C/T cg07810366 chr2:100720526 AFF3 -0.46 -5.95 -0.31 6.87e-9 Intelligence (multi-trait analysis); LUSC cis rs9549260 0.564 rs4943805 chr13:41270080 A/G cg21288729 chr13:41239152 FOXO1 0.53 8.01 0.4 1.99e-14 Red blood cell count; LUSC cis rs4144027 0.967 rs12879686 chr14:104360741 C/T cg01849466 chr14:104193079 ZFYVE21 -0.37 -5.67 -0.3 3.04e-8 Blood metabolite levels; LUSC cis rs2387326 0.671 rs12256275 chr10:129947139 T/C cg16087940 chr10:129947807 NA -0.39 -5.89 -0.31 9.25e-9 Select biomarker traits; LUSC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg23262073 chr20:60523788 NA -0.44 -6.23 -0.32 1.4e-9 Body mass index; LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg25072359 chr17:41440525 NA 0.68 9.69 0.47 9.97e-20 Menopause (age at onset); LUSC cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg23625390 chr15:77176239 SCAPER 0.53 8.27 0.41 3.11e-15 Blood metabolite levels; LUSC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08704250 chr15:31115839 NA -0.48 -7.12 -0.36 6.63e-12 Huntington's disease progression; LUSC cis rs6120849 0.754 rs6119560 chr20:33606977 G/C cg24642439 chr20:33292090 TP53INP2 0.62 6.82 0.35 4.29e-11 Protein C levels; LUSC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg07636037 chr3:49044803 WDR6 1.08 19.15 0.72 1.09e-55 Parkinson's disease; LUSC cis rs11191205 0.686 rs10883676 chr10:103445325 A/C cg15320455 chr10:103880129 LDB1 -0.46 -5.65 -0.3 3.43e-8 Intelligence (multi-trait analysis); LUSC cis rs983392 0.679 rs7930318 chr11:60033371 C/T cg24026212 chr11:59952134 MS4A6A 0.36 6.32 0.33 8.42e-10 Alzheimer's disease (late onset); LUSC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg13206674 chr6:150067644 NUP43 0.53 8.03 0.4 1.65e-14 Lung cancer; LUSC cis rs3772130 0.962 rs9812228 chr3:121495682 C/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.23 0.49 1.48e-21 Cognitive performance; LUSC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg19774624 chr17:42201019 HDAC5 0.72 10.55 0.5 1.22e-22 Total body bone mineral density; LUSC cis rs7818345 0.967 rs17479099 chr8:19277144 T/C cg11303988 chr8:19266685 CSGALNACT1 0.38 7.35 0.37 1.57e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs453301 0.562 rs1038248 chr8:9040858 G/T cg06636001 chr8:8085503 FLJ10661 -0.41 -6.1 -0.32 2.86e-9 Joint mobility (Beighton score); LUSC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg05347473 chr6:146136440 FBXO30 0.56 9.76 0.47 6e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.54 0.34 2.27e-10 Tonsillectomy; LUSC trans rs9860340 0.690 rs67833493 chr3:87635809 C/T cg03644585 chr7:884825 UNC84A 0.42 6.09 0.32 3.17e-9 Electroencephalographic traits in alcoholism; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.38 0.33 5.75e-10 Calcium levels; LUSC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg08270630 chr22:50330655 NA 0.4 5.94 0.31 7.32e-9 Schizophrenia; LUSC cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg11057378 chr10:81107060 PPIF 0.34 5.73 0.3 2.3e-8 Height; LUSC cis rs7147624 1.000 rs11848209 chr14:66022832 T/A cg03016385 chr14:66212404 NA -0.85 -9.58 -0.46 2.21e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12477438 0.765 rs2309521 chr2:99592069 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.51e-15 Chronic sinus infection; LUSC cis rs4494114 0.967 rs9439083 chr1:39344766 C/T cg25970120 chr1:39325951 RRAGC -0.41 -6.47 -0.33 3.56e-10 Blood protein levels; LUSC cis rs6840360 0.571 rs10026670 chr4:152539212 C/T cg22705602 chr4:152727874 NA -0.32 -6.59 -0.34 1.73e-10 Intelligence (multi-trait analysis); LUSC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg06609049 chr19:2785107 THOP1 -1.12 -21.84 -0.77 2.7e-66 Total cholesterol levels; LUSC trans rs12210905 0.920 rs72839453 chr6:27265761 A/G cg11837749 chr1:55047332 ACOT11 0.66 6.32 0.33 8.31e-10 Hip circumference adjusted for BMI; LUSC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19346786 chr7:2764209 NA -0.44 -7.56 -0.38 3.82e-13 Height; LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg18758796 chr5:131593413 PDLIM4 0.41 6.79 0.35 5.11e-11 Breast cancer; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg10802521 chr3:52805072 NEK4 -0.49 -7.86 -0.4 5.4e-14 Bipolar disorder; LUSC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg14262678 chr6:151773367 RMND1;C6orf211 0.48 7.68 0.39 1.75e-13 Menarche (age at onset); LUSC cis rs7072216 0.763 rs7091709 chr10:100167605 G/A cg26618903 chr10:100175079 PYROXD2 -0.44 -8.37 -0.42 1.56e-15 Metabolite levels; LUSC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg14829155 chr15:31115871 NA -0.57 -7.93 -0.4 3.23e-14 Huntington's disease progression; LUSC trans rs11250098 0.574 rs7015168 chr8:10772210 G/C cg06636001 chr8:8085503 FLJ10661 -0.53 -7.47 -0.38 7.04e-13 Morning vs. evening chronotype; LUSC cis rs3931020 0.508 rs2345436 chr1:75198740 A/C cg21906852 chr1:75198582 TYW3;CRYZ 0.45 6.45 0.33 4.02e-10 Resistin levels; LUSC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg10792982 chr14:105748885 BRF1 0.5 9.13 0.45 6.94e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs6499755 0.965 rs2042448 chr16:55352063 G/A cg02859129 chr16:55357253 IRX6 0.35 5.91 0.31 8.5e-9 Hypospadias; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg27094323 chr7:1216898 NA -0.43 -7.32 -0.37 1.92e-12 Longevity;Endometriosis; LUSC cis rs1577917 0.958 rs12213343 chr6:86443019 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.84 -0.44 5.48e-17 Response to antipsychotic treatment; LUSC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg27608139 chr16:2294856 DCI 0.42 7.98 0.4 2.44e-14 Height; LUSC cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg03146154 chr1:46216737 IPP 0.5 7.43 0.38 9.1e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs847577 0.748 rs940430 chr7:97716540 A/G cg21770322 chr7:97807741 LMTK2 0.5 8.59 0.43 3.5e-16 Breast cancer; LUSC cis rs116139393 0.611 rs62439722 chr7:6764940 G/A cg09896999 chr7:6746977 ZNF12 -0.51 -6.91 -0.35 2.46e-11 Alzheimer's disease (APOE e4 interaction); LUSC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg07636037 chr3:49044803 WDR6 1.0 16.07 0.66 1.81e-43 Parkinson's disease; LUSC cis rs6722750 0.683 rs2901647 chr2:64418097 G/C cg22352474 chr2:64371530 PELI1 -0.51 -7.67 -0.39 1.89e-13 Neuroticism; LUSC cis rs11229555 0.645 rs1986404 chr11:58194614 T/C cg15696309 chr11:58395628 NA -0.67 -8.13 -0.41 8.64e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg13939156 chr17:80058883 NA -0.32 -6.29 -0.33 1.01e-9 Life satisfaction; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16322581 chr12:70636648 CNOT2 -0.52 -6.48 -0.33 3.32e-10 Bipolar disorder and schizophrenia; LUSC cis rs4595586 0.545 rs12820138 chr12:39357049 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg14416269 chr4:6271139 WFS1 0.5 10.55 0.5 1.2e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs61931739 1.000 rs11052967 chr12:34020030 T/G cg06521331 chr12:34319734 NA 0.4 6.55 0.34 2.17e-10 Morning vs. evening chronotype; LUSC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg12863693 chr15:85201151 NMB 0.35 6.97 0.36 1.68e-11 Schizophrenia; LUSC cis rs2625529 0.713 rs16956634 chr15:72552243 C/G cg16672083 chr15:72433130 SENP8 0.49 7.29 0.37 2.32e-12 Red blood cell count; LUSC trans rs9329221 0.662 rs12541491 chr8:10250048 C/T cg06636001 chr8:8085503 FLJ10661 0.56 7.71 0.39 1.41e-13 Neuroticism; LUSC cis rs17102423 0.755 rs8009714 chr14:65573446 G/T cg11161011 chr14:65562177 MAX -0.81 -12.19 -0.55 1.57e-28 Obesity-related traits; LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs9467711 0.559 rs12176129 chr6:26514940 C/T cg12826209 chr6:26865740 GUSBL1 0.64 5.72 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs11098499 0.542 rs7677836 chr4:120310638 T/A cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs2839186 0.721 rs13051200 chr21:47701693 A/T cg05896524 chr21:47604654 C21orf56 0.4 5.91 0.31 8.52e-9 Testicular germ cell tumor; LUSC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg14552801 chr7:65878734 NA 0.38 5.79 0.3 1.65e-8 Aortic root size; LUSC cis rs9517320 0.967 rs9517317 chr13:99125711 G/C cg07423050 chr13:99094983 FARP1 0.33 6.35 0.33 6.94e-10 Longevity; LUSC cis rs10465746 0.935 rs4907189 chr1:84374982 G/T cg10977910 chr1:84465055 TTLL7 0.43 6.14 0.32 2.33e-9 Obesity-related traits; LUSC cis rs61931739 0.963 rs12298565 chr12:34036188 C/T cg06521331 chr12:34319734 NA 0.4 6.61 0.34 1.48e-10 Morning vs. evening chronotype; LUSC cis rs73198271 0.628 rs11783457 chr8:8588842 G/C cg01851573 chr8:8652454 MFHAS1 0.48 6.05 0.31 3.9e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4242434 0.927 rs3735901 chr8:22462374 T/C cg03733263 chr8:22462867 KIAA1967 1.02 19.27 0.73 3.62e-56 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs3020736 0.500 rs6002605 chr22:42494335 A/G cg15557168 chr22:42548783 NA 0.48 7.39 0.38 1.16e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs1568889 1.000 rs7951681 chr11:28273894 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.32 0.45 1.66e-18 Bipolar disorder; LUSC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg01181863 chr3:195395398 SDHAP2 -0.6 -8.15 -0.41 7.43e-15 Pancreatic cancer; LUSC cis rs7592578 0.771 rs4258824 chr2:191395027 C/T cg11845111 chr2:191398756 TMEM194B -0.87 -11.29 -0.53 2.84e-25 Diastolic blood pressure; LUSC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg25258033 chr6:167368657 RNASET2 0.44 7.05 0.36 1.02e-11 Crohn's disease; LUSC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg20891283 chr12:69753455 YEATS4 0.81 14.27 0.62 2.16e-36 Blood protein levels; LUSC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg20476274 chr7:133979776 SLC35B4 0.87 17.01 0.68 3.43e-47 Mean platelet volume; LUSC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.45 -7.93 -0.4 3.43e-14 Total body bone mineral density; LUSC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg17971929 chr21:40555470 PSMG1 0.77 13.37 0.59 5.99e-33 Cognitive function; LUSC trans rs867371 0.502 rs3759800 chr15:82532963 A/C cg04831495 chr15:85060580 GOLGA6L5 0.38 6.39 0.33 5.49e-10 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs34779708 0.733 rs7070778 chr10:35541688 T/C cg03585969 chr10:35415529 CREM 0.54 7.56 0.38 4.03e-13 Inflammatory bowel disease;Crohn's disease; LUSC trans rs7726839 0.574 rs11739866 chr5:636299 C/T cg11887960 chr12:57824829 NA 0.54 6.65 0.34 1.18e-10 Obesity-related traits; LUSC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08109568 chr15:31115862 NA 0.49 6.98 0.36 1.56e-11 Huntington's disease progression; LUSC cis rs12681288 0.823 rs12681230 chr8:994422 G/A cg04851639 chr8:1020857 NA -0.41 -8.71 -0.43 1.39e-16 Schizophrenia; LUSC cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg24558204 chr6:135376177 HBS1L 0.67 10.49 0.5 2e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg13319975 chr6:146136371 FBXO30 0.5 7.48 0.38 6.8e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg08132940 chr7:1081526 C7orf50 -0.48 -5.95 -0.31 6.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3816788 0.837 rs6557640 chr8:21771731 A/T cg17168535 chr8:21777572 XPO7 0.69 11.68 0.54 1.16e-26 Lung cancer in ever smokers; LUSC cis rs62400317 0.859 rs72870950 chr6:45154779 A/G cg20913747 chr6:44695427 NA -0.47 -7.46 -0.38 7.32e-13 Total body bone mineral density; LUSC cis rs11583043 0.958 rs12730160 chr1:101438791 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.25 0.32 1.22e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs17286411 1.000 rs17286411 chr16:71968701 C/G cg03805757 chr16:71968109 PKD1L3 0.37 5.96 0.31 6.38e-9 Blood protein levels; LUSC cis rs554111 0.660 rs12042978 chr1:21170811 T/C cg01072550 chr1:21505969 NA 0.39 5.96 0.31 6.44e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg02574844 chr11:5959923 NA -0.5 -7.94 -0.4 3.11e-14 DNA methylation (variation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12698784 chr3:119813316 GSK3B -0.4 -5.95 -0.31 6.8e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg08859206 chr1:53392774 SCP2 0.51 8.74 0.43 1.18e-16 Monocyte count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16491909 chr1:154193730 C1orf43;UBAP2L 0.46 6.45 0.33 4.03e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg08470875 chr2:26401718 FAM59B 0.75 9.99 0.48 1e-20 Gut microbiome composition (summer); LUSC cis rs2439831 0.557 rs13329084 chr15:44151063 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.94 -8.7 -0.43 1.5e-16 Lung cancer in ever smokers; LUSC cis rs11122272 0.735 rs2437150 chr1:231488524 A/G cg06096015 chr1:231504339 EGLN1 -0.52 -9.38 -0.46 1.02e-18 Hemoglobin concentration; LUSC cis rs9914988 1.000 rs901975 chr17:27189774 A/G cg09479241 chr17:27052676 TLCD1 -0.43 -5.79 -0.3 1.65e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs76878669 0.561 rs7117630 chr11:66154777 C/T cg24851651 chr11:66362959 CCS 0.37 5.89 0.31 9.66e-9 Educational attainment (years of education); LUSC cis rs3744061 0.557 rs9889902 chr17:74648034 T/C cg27546012 chr17:74684504 MXRA7 -0.39 -6.47 -0.33 3.43e-10 Retinal arteriolar caliber; LUSC cis rs56399783 0.901 rs6964740 chr7:2819656 C/G cg19731401 chr7:2775893 GNA12 0.6 8.04 0.4 1.6e-14 Childhood ear infection; LUSC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg23262073 chr20:60523788 NA -0.42 -5.87 -0.31 1.05e-8 Body mass index; LUSC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg11871910 chr12:69753446 YEATS4 0.62 9.83 0.47 3.37e-20 Response to diuretic therapy; LUSC cis rs380904 1.000 rs12543128 chr8:144595042 G/A cg20583945 chr8:144636462 GSDMD 0.42 5.65 0.3 3.37e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg01191920 chr7:158217561 PTPRN2 -0.58 -11.9 -0.55 1.78e-27 Obesity-related traits; LUSC cis rs2625529 0.824 rs12439900 chr15:72373640 A/G cg16672083 chr15:72433130 SENP8 -0.52 -7.64 -0.39 2.38e-13 Red blood cell count; LUSC trans rs7309687 1.000 rs4288814 chr12:43067451 A/G cg05280148 chr16:30134882 MAPK3 -0.43 -6.21 -0.32 1.61e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9473147 0.543 rs13211285 chr6:47479618 C/T cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg26384229 chr12:38710491 ALG10B 0.8 14.23 0.61 2.9e-36 Morning vs. evening chronotype; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18099408 chr3:52552593 STAB1 -0.44 -7.74 -0.39 1.17e-13 Bipolar disorder; LUSC cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg10523679 chr1:76189770 ACADM -0.48 -7.11 -0.36 7.25e-12 Daytime sleep phenotypes; LUSC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg13206674 chr6:150067644 NUP43 0.59 9.36 0.46 1.24e-18 Lung cancer; LUSC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg05623727 chr3:50126028 RBM5 -0.32 -6.1 -0.32 2.86e-9 Body mass index; LUSC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg24531977 chr5:56204891 C5orf35 0.86 13.99 0.61 2.45e-35 Initial pursuit acceleration; LUSC trans rs3857536 0.813 rs6904511 chr6:66939102 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs68170813 0.559 rs6963917 chr7:106953427 T/G cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC cis rs12188164 0.525 rs1114665 chr5:452247 C/T cg15813090 chr5:442598 EXOC3;C5orf55 -0.37 -5.74 -0.3 2.13e-8 Cystic fibrosis severity; LUSC cis rs7617480 0.616 rs7429596 chr3:48808531 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.34 0.46 1.38e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs9309473 1.000 rs13431267 chr2:73782200 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.45 -0.33 4.02e-10 Metabolite levels; LUSC cis rs250677 0.522 rs10050928 chr5:148353463 C/A cg18129178 chr5:148520854 ABLIM3 0.53 7.56 0.38 3.89e-13 Breast cancer; LUSC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg16928487 chr17:17741425 SREBF1 0.36 6.77 0.35 5.75e-11 Total body bone mineral density; LUSC trans rs61931739 0.649 rs12426686 chr12:33714473 A/G cg26384229 chr12:38710491 ALG10B -0.42 -6.17 -0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.1 0.41 1.07e-14 Bipolar disorder; LUSC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03264133 chr6:25882463 NA -0.54 -9.26 -0.45 2.57e-18 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs34311866 0.808 rs4583705 chr4:973036 C/T cg07828340 chr4:882639 GAK 0.97 9.94 0.48 1.5e-20 Parkinson's disease; LUSC cis rs28374715 0.578 rs10518717 chr15:41623368 C/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -22.34 -0.77 2.99e-68 Ulcerative colitis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16025584 chr9:139887217 C9orf142 0.41 6.14 0.32 2.3e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg03188948 chr7:1209495 NA 0.63 6.64 0.34 1.3e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg08677398 chr8:58056175 NA 0.47 5.98 0.31 5.86e-9 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg13560548 chr3:10150139 C3orf24 -0.53 -7.72 -0.39 1.4e-13 Alzheimer's disease; LUSC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs7192380 0.965 rs7205551 chr16:69605968 G/A cg26679644 chr16:69762563 NA 0.34 6.04 0.31 4.02e-9 Sjögren's syndrome; LUSC trans rs8072100 0.748 rs9908016 chr17:45551361 G/A cg04995722 chr7:26192034 NFE2L3 -0.43 -6.67 -0.34 1.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7119 0.678 rs12914098 chr15:77823013 C/T cg27398640 chr15:77910606 LINGO1 -0.3 -6.32 -0.33 8.13e-10 Type 2 diabetes; LUSC trans rs7824557 0.591 rs2736283 chr8:11225910 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.47 -0.38 7e-13 Retinal vascular caliber; LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.13 0.41 8.64e-15 Bipolar disorder; LUSC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg04865166 chr7:105162814 PUS7 0.53 5.87 0.31 1.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs11864453 0.647 rs3764314 chr16:72127078 T/C cg16558253 chr16:72132732 DHX38 -0.37 -5.76 -0.3 1.86e-8 Fibrinogen levels; LUSC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg01579765 chr21:45077557 HSF2BP -0.48 -10.11 -0.48 3.97e-21 Mean corpuscular volume; LUSC cis rs6690583 0.623 rs2028304 chr1:85488030 G/A cg22153463 chr1:85462885 MCOLN2 -0.58 -5.73 -0.3 2.3e-8 Serum sulfate level; LUSC trans rs7824557 0.510 rs1435274 chr8:11235910 G/A cg15556689 chr8:8085844 FLJ10661 -0.48 -7.23 -0.37 3.28e-12 Retinal vascular caliber; LUSC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.69 0.6 3.45e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg00166722 chr3:10149974 C3orf24 0.54 7.45 0.38 7.83e-13 Alzheimer's disease; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg08677398 chr8:58056175 NA 0.52 7.04 0.36 1.09e-11 Developmental language disorder (linguistic errors); LUSC cis rs11711311 0.822 rs9850256 chr3:113408382 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.22 0.32 1.46e-9 IgG glycosylation; LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg16393715 chr7:1948819 MAD1L1 -0.36 -6.28 -0.32 1.05e-9 Bipolar disorder and schizophrenia; LUSC cis rs835154 0.900 rs835153 chr5:14877474 A/G cg14843632 chr5:14870594 ANKH 0.42 7.89 0.4 4.29e-14 Blood metabolite levels; LUSC cis rs7223966 0.515 rs2727315 chr17:61961458 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.95 0.36 1.96e-11 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs804280 0.543 rs13261205 chr8:11791216 A/G cg14343924 chr8:8086146 FLJ10661 0.44 6.11 0.32 2.74e-9 Myopia (pathological); LUSC trans rs7829975 0.564 rs2921060 chr8:8317817 G/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.46 -0.33 3.61e-10 Mood instability; LUSC cis rs9329221 0.905 rs28712068 chr8:10251145 G/C cg21775007 chr8:11205619 TDH -0.55 -7.97 -0.4 2.54e-14 Neuroticism; LUSC cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.92 -0.35 2.28e-11 Menopause (age at onset); LUSC cis rs6547741 0.935 rs6547738 chr2:27852637 A/G cg27432699 chr2:27873401 GPN1 0.83 15.85 0.66 1.4e-42 Oral cavity cancer; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg22868518 chr11:507468 RNH1 -0.65 -5.92 -0.31 8.03e-9 Body mass index; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg18538332 chr22:24372958 LOC391322 -0.47 -8.47 -0.42 8.05e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg14440974 chr22:39074834 NA -0.39 -6.46 -0.33 3.67e-10 Menopause (age at onset); LUSC cis rs9341808 0.628 rs2490245 chr6:80892427 A/G cg08355045 chr6:80787529 NA 0.48 8.2 0.41 5.06e-15 Sitting height ratio; LUSC cis rs9486719 0.895 rs3798294 chr6:97049587 G/A cg06623918 chr6:96969491 KIAA0776 -0.84 -10.5 -0.5 1.72e-22 Migraine;Coronary artery disease; LUSC cis rs8038465 0.622 rs7182124 chr15:73915254 C/T cg15420318 chr15:73925796 NPTN 0.55 9.48 0.46 4.97e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs72949976 0.584 rs13001511 chr2:214025262 G/A cg08319019 chr2:214017104 IKZF2 0.68 11.62 0.54 1.9e-26 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.26 -0.37 2.69e-12 Major depressive disorder; LUSC trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg23533926 chr12:111358616 MYL2 0.34 6.12 0.32 2.64e-9 Extrinsic epigenetic age acceleration; LUSC cis rs753274 0.650 rs28497965 chr19:14417402 T/G cg25450033 chr19:14444658 NA 0.36 5.99 0.31 5.3300000000000004e-09 Tumor necrosis factor beta levels; LUSC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg26441486 chr22:50317300 CRELD2 -0.54 -8.2 -0.41 5.14e-15 Schizophrenia; LUSC cis rs17539620 0.534 rs7768635 chr6:154827861 C/T cg20019720 chr6:154832845 CNKSR3 0.58 8.67 0.43 1.91e-16 Lipoprotein (a) levels; LUSC cis rs7267979 1.000 rs2257808 chr20:25266450 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.54 0.75 3.49e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7520050 0.778 rs3013597 chr1:46128356 C/A cg24296786 chr1:45957014 TESK2 -0.41 -5.81 -0.3 1.47e-8 Red blood cell count;Reticulocyte count; LUSC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -11.85 -0.54 2.83e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg14784868 chr12:69753453 YEATS4 0.89 15.67 0.65 7.27e-42 Cerebrospinal fluid biomarker levels; LUSC cis rs10910092 1 rs10910092 chr1:2501516 A/G cg18854424 chr1:2615690 NA 0.46 9.58 0.46 2.38e-19 Ulcerative colitis; LUSC cis rs72781680 0.898 rs12623079 chr2:24103749 G/A cg08917208 chr2:24149416 ATAD2B 0.88 10.02 0.48 7.83e-21 Lymphocyte counts; LUSC cis rs7572733 0.534 rs13026569 chr2:198783330 C/G cg00792783 chr2:198669748 PLCL1 -0.44 -5.96 -0.31 6.57e-9 Dermatomyositis; LUSC cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 13.58 0.6 9.08e-34 Chronic sinus infection; LUSC cis rs6733011 0.500 rs7560696 chr2:99405800 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -5.96 -0.31 6.58e-9 Bipolar disorder; LUSC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.66 0.39 2.07e-13 Vitiligo; LUSC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg01256987 chr12:42539512 GXYLT1 0.45 8.58 0.42 3.75e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16203607 chr17:62500946 DDX5 0.35 6.26 0.32 1.18e-9 Triglycerides; LUSC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg26408565 chr15:76604113 ETFA -0.5 -8.05 -0.4 1.45e-14 Blood metabolite levels; LUSC cis rs17661538 0.504 rs11591660 chr10:18432750 C/G cg03634479 chr10:18430412 CACNB2 0.67 6.29 0.33 9.7e-10 Response to antipsychotic treatment; LUSC cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg18681998 chr4:17616180 MED28 0.86 15.62 0.65 1.1e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4332037 0.539 rs55790766 chr7:2021248 C/T cg10840412 chr1:235813424 GNG4 0.6 7.72 0.39 1.38e-13 Bipolar disorder; LUSC cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.28 0.37 2.34e-12 Cognitive ability; LUSC cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg02527881 chr3:46936655 PTH1R -0.39 -6.85 -0.35 3.66e-11 Colorectal cancer; LUSC cis rs975210 0.656 rs16954106 chr15:70357918 C/T cg12349571 chr15:70364359 TLE3 -0.6 -7.11 -0.36 7.28e-12 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; LUSC cis rs7100689 0.646 rs10749579 chr10:82140959 C/T cg01528321 chr10:82214614 TSPAN14 0.87 13.3 0.59 1.1e-32 Post bronchodilator FEV1; LUSC cis rs4285028 0.948 rs12497349 chr3:121708517 T/C cg11130432 chr3:121712080 ILDR1 -0.65 -10.09 -0.48 4.39e-21 Multiple sclerosis; LUSC cis rs68170813 0.641 rs79328953 chr7:106901557 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.92 -0.48 1.74e-20 Coronary artery disease; LUSC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg15147215 chr3:52552868 STAB1 -0.33 -6.45 -0.33 3.88e-10 Intelligence (multi-trait analysis); LUSC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg11764359 chr7:65958608 NA -0.68 -10.47 -0.5 2.3e-22 Aortic root size; LUSC cis rs10162002 0.872 rs3764067 chr13:24042897 T/C cg00158254 chr13:24040743 NA 0.54 6.03 0.31 4.46e-9 Hypothyroidism; LUSC cis rs7264396 0.580 rs2425173 chr20:34445142 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -6.78 -0.35 5.47e-11 Total cholesterol levels; LUSC cis rs9329289 0.510 rs28579610 chr10:2546080 C/A cg15501526 chr10:2543763 NA 0.56 9.92 0.48 1.64e-20 Age-related hearing impairment; LUSC cis rs7582720 1.000 rs76890136 chr2:203850011 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9527 0.640 rs6584541 chr10:104929124 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.4 0.46 8.7e-19 Arsenic metabolism; LUSC trans rs11098499 0.691 rs12510133 chr4:120271344 A/C cg25214090 chr10:38739885 LOC399744 0.39 5.96 0.31 6.43e-9 Corneal astigmatism; LUSC cis rs977987 0.843 rs62062568 chr16:75445324 T/C cg03315344 chr16:75512273 CHST6 0.53 10.2 0.49 1.89e-21 Dupuytren's disease; LUSC cis rs9788682 0.747 rs16969894 chr15:78776456 C/T cg24631222 chr15:78858424 CHRNA5 0.64 8.42 0.42 1.09e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7712401 0.601 rs13155907 chr5:122334633 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.22 -0.45 3.4e-18 Mean platelet volume; LUSC cis rs6599077 1.000 rs2068977 chr3:40095152 A/T cg13683864 chr3:40499215 RPL14 -0.6 -7.66 -0.39 2.06e-13 Sleep-related phenotypes; LUSC trans rs804280 0.509 rs13276433 chr8:11783036 A/G cg27411982 chr8:10470053 RP1L1 0.4 6.26 0.32 1.19e-9 Myopia (pathological); LUSC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg25019033 chr10:957182 NA 0.5 6.26 0.32 1.2e-9 Eosinophil percentage of granulocytes; LUSC cis rs3741798 1.000 rs55865572 chr12:12497333 T/C cg08615371 chr12:12503544 MANSC1 1.08 11.07 0.52 1.79e-24 Cerebrospinal fluid biomarker levels; LUSC trans rs7181230 0.885 rs28826672 chr15:40360366 G/T cg22705835 chr10:65332833 REEP3 -0.39 -6.27 -0.32 1.12e-9 Dehydroepiandrosterone sulphate levels; LUSC cis rs73206853 0.841 rs73191808 chr12:110904685 T/C cg12870014 chr12:110450643 ANKRD13A 0.67 6.46 0.33 3.72e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs672059 1.000 rs674343 chr1:183162052 G/A ch.1.3577855R chr1:183094577 LAMC1 0.55 7.96 0.4 2.78e-14 Hypertriglyceridemia; LUSC cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs748404 0.697 rs572959 chr15:43550502 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.42 6.11 0.32 2.83e-9 Lung cancer; LUSC cis rs9814567 0.964 rs1534028 chr3:134284639 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.05 -0.61 1.51e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg13206674 chr6:150067644 NUP43 0.63 10.38 0.49 4.6e-22 Lung cancer; LUSC cis rs28795989 0.795 rs4696778 chr4:7919308 C/G cg24250820 chr4:7887609 AFAP1 -0.48 -8.92 -0.44 3.13e-17 Intraocular pressure; LUSC trans rs6598955 0.671 rs17162105 chr1:26591255 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs7577696 0.597 rs11691939 chr2:32339561 A/G cg02381751 chr2:32503542 YIPF4 0.51 7.01 0.36 1.31e-11 Inflammatory biomarkers; LUSC cis rs4803468 0.934 rs11880674 chr19:41889423 A/T cg09537434 chr19:41945824 ATP5SL -0.89 -15.69 -0.65 6e-42 Height; LUSC cis rs6669008 1.000 rs55912359 chr1:114167099 C/T cg13572289 chr1:114447746 DCLRE1B;AP4B1 -0.36 -5.73 -0.3 2.21e-8 Bacteremia; LUSC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.12 0.41 9.01e-15 Homoarginine levels; LUSC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg15782153 chr7:917662 C7orf20 0.43 6.52 0.34 2.54e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg16928487 chr17:17741425 SREBF1 0.37 7.13 0.36 6.28e-12 Total body bone mineral density; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg02723225 chr16:3019192 PAQR4 0.38 6.04 0.31 4.1e-9 Schizophrenia (age at onset); LUSC trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21659725 chr3:3221576 CRBN -0.58 -8.06 -0.4 1.35e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18404041 chr3:52824283 ITIH1 -0.68 -13.31 -0.59 9.73e-33 Bipolar disorder; LUSC cis rs4363385 0.818 rs423692 chr1:153005681 T/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC trans rs35110281 0.776 rs9983763 chr21:44990578 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.64 -10.83 -0.51 1.27e-23 Mean corpuscular volume; LUSC cis rs9807989 0.801 rs72823663 chr2:102968738 G/C cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs9527 0.569 rs10786730 chr10:104724200 G/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.61 -0.34 1.54e-10 Arsenic metabolism; LUSC cis rs6918586 0.594 rs198842 chr6:26111448 C/T cg17691542 chr6:26056736 HIST1H1C 0.4 5.99 0.31 5.45e-9 Schizophrenia; LUSC cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg06784218 chr1:46089804 CCDC17 0.48 9.57 0.46 2.47e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg18196295 chr10:418757 DIP2C 0.5 8.29 0.41 2.88e-15 Psychosis in Alzheimer's disease; LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.86 0.35 3.29e-11 Platelet count; LUSC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg18681998 chr4:17616180 MED28 0.77 13.81 0.6 1.24e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs654950 0.806 rs2759251 chr1:42041749 C/G cg06885757 chr1:42089581 HIVEP3 -0.44 -9.01 -0.44 1.57e-17 Airway imaging phenotypes; LUSC cis rs5771242 0.518 rs6010216 chr22:50679471 C/T cg16473166 chr22:50639996 SELO 0.72 10.06 0.48 5.85e-21 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); LUSC cis rs4975709 0.686 rs2307118 chr5:1881916 A/C cg20790798 chr5:1857306 NA -0.38 -5.66 -0.3 3.27e-8 Cardiovascular disease risk factors; LUSC cis rs7241530 0.662 rs55634452 chr18:75902067 A/G cg14642773 chr18:75888474 NA 0.4 5.86 0.31 1.11e-8 Educational attainment (years of education); LUSC cis rs9311676 0.632 rs11130630 chr3:58360800 A/G cg26110898 chr3:58419937 PDHB 0.41 6.64 0.34 1.28e-10 Systemic lupus erythematosus; LUSC cis rs78572108 0.858 rs13397360 chr2:42265162 T/A cg00607755 chr2:42274082 PKDCC 0.36 6.52 0.34 2.61e-10 Total body bone mineral density; LUSC trans rs7980799 0.905 rs4244865 chr12:33511917 C/T cg26384229 chr12:38710491 ALG10B -0.41 -5.96 -0.31 6.41e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2832077 0.824 rs4816333 chr21:30201777 C/G cg08807101 chr21:30365312 RNF160 -0.54 -6.85 -0.35 3.48e-11 Cognitive test performance; LUSC cis rs9457247 0.902 rs366938 chr6:167403538 T/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs3764021 0.933 rs2268146 chr12:9869271 A/G cg20894963 chr12:9885564 CLECL1 0.35 7.02 0.36 1.23e-11 Type 1 diabetes; LUSC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.74 -0.35 6.77e-11 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg13010199 chr12:38710504 ALG10B 0.64 9.79 0.47 4.49e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg26769984 chr7:1090371 C7orf50 0.59 8.17 0.41 6.32e-15 Bronchopulmonary dysplasia; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.56 -9.4 -0.46 9.24e-19 Lymphocyte counts; LUSC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg03929089 chr4:120376271 NA -0.49 -6.91 -0.35 2.47e-11 HDL cholesterol; LUSC cis rs7809950 0.731 rs4730238 chr7:107054787 G/A cg23024343 chr7:107201750 COG5 -0.7 -10.09 -0.48 4.47e-21 Coronary artery disease; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg00510360 chr3:108308232 KIAA1524;DZIP3 0.49 6.23 0.32 1.44e-9 Cognitive function;Information processing speed; LUSC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg12311346 chr5:56204834 C5orf35 -0.55 -8.5 -0.42 6.48e-16 Coronary artery disease; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg20295408 chr7:1910781 MAD1L1 0.42 6.06 0.31 3.61e-9 Bipolar disorder and schizophrenia; LUSC cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg05868516 chr6:26286170 HIST1H4H 0.37 6.1 0.32 2.86e-9 Educational attainment; LUSC cis rs9807989 0.507 rs2310300 chr2:103049074 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.98e-12 Asthma; LUSC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg14983838 chr19:29218262 NA 0.55 6.21 0.32 1.53e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg24812749 chr6:127587940 RNF146 -0.62 -8.84 -0.44 5.43e-17 Breast cancer; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.36 0.37 1.48e-12 Prudent dietary pattern; LUSC cis rs4917300 0.549 rs902819 chr8:143098548 C/T cg25363559 chr8:143086065 NA -0.32 -7.15 -0.36 5.52e-12 Amyotrophic lateral sclerosis; LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg05025164 chr4:1340916 KIAA1530 -0.64 -10.07 -0.48 5.35e-21 Obesity-related traits; LUSC cis rs73071352 0.577 rs73075228 chr3:42049629 T/G cg03022575 chr3:42003672 ULK4 0.79 7.96 0.4 2.75e-14 Multiple myeloma and monoclonal gammopathy;Multiple myeloma; LUSC trans rs2797160 1.000 rs78602343 chr6:126019768 T/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.94 0.36 2.04e-11 Endometrial cancer; LUSC trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg15704280 chr7:45808275 SEPT13 -0.83 -11.71 -0.54 8.72e-27 Coronary artery disease; LUSC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg18230493 chr5:56204884 C5orf35 -0.64 -9.93 -0.48 1.53e-20 Coronary artery disease; LUSC cis rs10097731 0.901 rs9298344 chr8:82043063 C/T cg25230327 chr8:82042993 NA -0.48 -7.06 -0.36 9.8e-12 Serum total protein level; LUSC cis rs9788682 1.000 rs7163730 chr15:78814681 A/G cg06917634 chr15:78832804 PSMA4 -0.56 -6.95 -0.36 1.97e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg11050988 chr7:1952600 MAD1L1 -0.31 -5.89 -0.31 9.17e-9 Bipolar disorder and schizophrenia; LUSC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg04315214 chr1:2043799 PRKCZ 0.49 10.42 0.5 3.37e-22 Height; LUSC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg27572855 chr1:25598939 RHD 0.43 7.5 0.38 5.96e-13 Erythrocyte sedimentation rate; LUSC cis rs5769765 0.908 rs7410601 chr22:50317187 C/T cg08270630 chr22:50330655 NA -0.46 -6.85 -0.35 3.56e-11 Schizophrenia; LUSC cis rs41271473 0.948 rs17437060 chr1:228822374 C/T cg16512390 chr1:228756714 NA 0.55 6.53 0.34 2.42e-10 Chronic lymphocytic leukemia; LUSC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.45 0.46 5.94e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12681287 0.547 rs6998303 chr8:87510185 T/C cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs7315438 0.785 rs10850518 chr12:115898565 C/A cg24172291 chr12:115889509 NA -0.34 -5.72 -0.3 2.33e-8 Colorectal cancer; LUSC cis rs1595825 0.891 rs73056823 chr2:198769788 T/C cg10547527 chr2:198650123 BOLL -0.49 -5.72 -0.3 2.32e-8 Ulcerative colitis; LUSC cis rs259282 0.628 rs35946544 chr19:33109983 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.67 10.01 0.48 8.13e-21 Schizophrenia; LUSC cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg27446573 chr6:127587934 RNF146 0.91 15.04 0.64 2.2e-39 Breast cancer; LUSC cis rs11051970 0.655 rs7298381 chr12:32530257 G/T cg02745156 chr12:32552066 NA 0.39 7.0 0.36 1.44e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs6952808 0.723 rs11766575 chr7:2005747 T/C cg04565464 chr8:145669602 NFKBIL2 0.37 6.13 0.32 2.44e-9 Bipolar disorder and schizophrenia; LUSC cis rs7106204 1.000 rs7106204 chr11:24236096 C/T ch.11.24196551F chr11:24239977 NA -1.04 -10.17 -0.49 2.5e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg02782426 chr3:40428986 ENTPD3 0.34 6.39 0.33 5.46e-10 Renal cell carcinoma; LUSC cis rs617219 0.890 rs72764981 chr5:78494003 C/T cg24856658 chr5:78533917 JMY -0.3 -5.86 -0.31 1.13e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs1185460 0.967 rs1307145 chr11:118950217 C/G cg01677386 chr11:118938358 VPS11 -0.49 -6.9 -0.35 2.61e-11 Coronary artery disease; LUSC trans rs11039798 0.512 rs1588069 chr11:48694871 A/G cg15704280 chr7:45808275 SEPT13 0.73 8.29 0.41 2.88e-15 Axial length; LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 14.92 0.63 6.36e-39 Platelet count; LUSC cis rs7568458 0.704 rs10176176 chr2:85762048 A/T cg17127132 chr2:85788382 GGCX 0.45 6.94 0.36 2e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7568458 0.660 rs6722691 chr2:85758352 C/T cg23752985 chr2:85803571 VAMP8 0.32 6.26 0.32 1.19e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs425277 1.000 rs12401379 chr1:2058580 G/C cg03732007 chr1:2071316 PRKCZ 0.48 7.77 0.39 9.67e-14 Height; LUSC trans rs11098499 0.955 rs7685268 chr4:120162188 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.27 0.32 1.09e-9 Corneal astigmatism; LUSC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC cis rs4925114 0.568 rs941448 chr17:17654542 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.97 -0.36 1.73e-11 Body mass index; LUSC cis rs7216064 1.000 rs59950564 chr17:65860859 A/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7568458 0.870 rs2366639 chr2:85809955 A/G cg23752985 chr2:85803571 VAMP8 0.38 8.17 0.41 6.53e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12188164 0.515 rs2672744 chr5:411047 A/G cg17553881 chr5:443987 EXOC3;C5orf55 0.3 6.65 0.34 1.18e-10 Cystic fibrosis severity; LUSC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs9329221 0.537 rs1484640 chr8:9983243 G/T cg21775007 chr8:11205619 TDH 0.44 6.27 0.32 1.13e-9 Neuroticism; LUSC cis rs694739 1.000 rs499425 chr11:64105929 A/G cg26898376 chr11:64110657 CCDC88B -0.36 -6.95 -0.36 1.88e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs11997175 0.766 rs4733176 chr8:33685334 A/T ch.8.33884649F chr8:33765107 NA 0.39 6.1 0.32 3e-9 Body mass index; LUSC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Vitiligo; LUSC cis rs2014572 0.967 rs4801452 chr19:57768066 A/G cg24459738 chr19:57751996 ZNF805 -0.51 -7.54 -0.38 4.41e-13 Hyperactive-impulsive symptoms; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg14668632 chr7:2872130 GNA12 -0.43 -6.07 -0.32 3.53e-9 Height; LUSC cis rs3931020 0.657 rs10890142 chr1:75179129 G/A cg21906852 chr1:75198582 TYW3;CRYZ 0.45 5.86 0.31 1.08e-8 Resistin levels; LUSC cis rs6456156 0.586 rs1358883 chr6:167467433 C/G cg06454157 chr6:167490870 NA 0.27 6.58 0.34 1.82e-10 Primary biliary cholangitis; LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg25767906 chr1:53392781 SCP2 0.47 8.55 0.42 4.37e-16 Monocyte count; LUSC cis rs79149102 0.579 rs59303424 chr15:75370014 G/A cg09165964 chr15:75287851 SCAMP5 -0.73 -6.73 -0.35 7.21e-11 Lung cancer; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg03188948 chr7:1209495 NA 0.62 6.56 0.34 2.03e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17102423 0.963 rs11626496 chr14:65600981 C/G cg11161011 chr14:65562177 MAX -0.62 -9.61 -0.47 1.88e-19 Obesity-related traits; LUSC trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 8.12e-16 Aortic root size; LUSC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg20302533 chr7:39170763 POU6F2 0.57 9.49 0.46 4.54e-19 IgG glycosylation; LUSC trans rs3733585 0.673 rs6843873 chr4:9958788 A/C cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.15e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg05347473 chr6:146136440 FBXO30 0.38 6.42 0.33 4.67e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs6599077 1.000 rs6599077 chr3:40096618 G/A cg13683864 chr3:40499215 RPL14 -0.6 -7.64 -0.39 2.38e-13 Sleep-related phenotypes; LUSC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg06713675 chr4:122721982 EXOSC9 -0.66 -11.62 -0.54 1.92e-26 Type 2 diabetes; LUSC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg27266027 chr21:40555129 PSMG1 -0.41 -5.92 -0.31 7.8e-9 Cognitive function; LUSC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg04553112 chr3:125709451 NA -0.5 -5.66 -0.3 3.27e-8 Blood pressure (smoking interaction); LUSC cis rs6598163 0.564 rs12319878 chr12:132289989 C/T cg07389463 chr12:132296394 NA 0.41 7.41 0.38 1.02e-12 Migraine; LUSC cis rs1448094 0.967 rs6539934 chr12:86343973 G/A cg02569458 chr12:86230093 RASSF9 0.41 6.65 0.34 1.23e-10 Major depressive disorder; LUSC cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg26924012 chr15:45694286 SPATA5L1 -1.09 -19.88 -0.74 1.39e-58 Homoarginine levels; LUSC cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg08213375 chr14:104286397 PPP1R13B 0.47 9.32 0.45 1.63e-18 Schizophrenia; LUSC cis rs12931792 0.682 rs12373113 chr16:30187513 C/T cg17640201 chr16:30407289 ZNF48 0.61 9.82 0.47 3.61e-20 Tonsillectomy; LUSC trans rs78049276 0.512 rs6820938 chr4:148395903 A/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.55 -6.35 -0.33 6.92e-10 Pulse pressure; LUSC trans rs11039798 0.588 rs11039781 chr11:48523085 T/G cg15704280 chr7:45808275 SEPT13 0.66 7.22 0.37 3.45e-12 Axial length; LUSC trans rs11764590 0.671 rs62444906 chr7:2083161 G/T cg25206134 chr2:45395956 NA 0.59 6.06 0.31 3.66e-9 Neuroticism; LUSC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg03060546 chr3:49711283 APEH 0.72 11.81 0.54 3.94e-27 Resting heart rate; LUSC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg09165964 chr15:75287851 SCAMP5 -1.15 -19.33 -0.73 2.1e-56 Blood trace element (Zn levels); LUSC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.35 0.33 6.99e-10 Tonsillectomy; LUSC cis rs7577696 0.785 rs7572964 chr2:32372096 A/T cg02381751 chr2:32503542 YIPF4 -0.43 -6.07 -0.32 3.38e-9 Inflammatory biomarkers; LUSC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.42 0.38 9.68e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9303401 0.659 rs12935851 chr17:56600244 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.95 0.58 2.35e-31 Cognitive test performance; LUSC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.03 0.4 1.67e-14 Parkinson's disease; LUSC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.65 -0.43 2.14e-16 Breast cancer; LUSC trans rs2204008 0.807 rs4123933 chr12:37973539 G/A cg06521331 chr12:34319734 NA -0.39 -5.98 -0.31 5.82e-9 Bladder cancer; LUSC cis rs5769765 0.913 rs28670284 chr22:50221973 C/T cg08270630 chr22:50330655 NA -0.4 -5.76 -0.3 1.93e-8 Schizophrenia; LUSC cis rs2731664 0.792 rs335468 chr5:176892349 A/G cg23176889 chr5:176863531 GRK6 0.66 13.78 0.6 1.56e-34 Intelligence (multi-trait analysis); LUSC cis rs12594515 0.967 rs11070466 chr15:45984955 C/T cg06207120 chr15:45996521 NA 0.4 6.14 0.32 2.33e-9 Waist circumference;Weight; LUSC cis rs2067615 0.524 rs4275715 chr12:107062246 C/T cg15890332 chr12:107067104 RFX4 0.34 6.06 0.31 3.72e-9 Heart rate; LUSC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2279817 0.863 rs6586569 chr1:18027377 T/C cg21791023 chr1:18019539 ARHGEF10L 0.48 6.8 0.35 4.82e-11 Neuroticism; LUSC trans rs8072100 0.576 rs7216112 chr17:45406345 C/T cg03185820 chr7:149158252 ZNF777 0.4 6.47 0.33 3.51e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2186369 0.681 rs5760020 chr22:24133092 G/A cg16317291 chr12:7076865 SCARNA12;PHB2 -0.4 -5.99 -0.31 5.48e-9 IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation; LUSC cis rs6842047 0.563 rs10025990 chr4:187146258 T/C cg09526685 chr4:187126073 CYP4V2 0.62 5.91 0.31 8.56e-9 Blood protein levels; LUSC cis rs4654899 0.571 rs34530426 chr1:21085204 C/T cg01072550 chr1:21505969 NA -0.47 -7.04 -0.36 1.07e-11 Superior frontal gyrus grey matter volume; LUSC cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg22681709 chr2:178499509 PDE11A -0.58 -11.31 -0.53 2.6e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg04518342 chr5:131593106 PDLIM4 0.36 6.69 0.34 9.4e-11 Blood metabolite levels; LUSC cis rs1957429 0.614 rs66883381 chr14:65334773 C/T cg23373153 chr14:65346875 NA -0.88 -8.1 -0.41 1.06e-14 Pediatric areal bone mineral density (radius); LUSC cis rs912057 0.671 rs1294427 chr6:6744546 T/G cg06612196 chr6:6737390 NA 0.56 11.11 0.52 1.32e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.55 0.46 2.95e-19 Prudent dietary pattern; LUSC cis rs26868 0.690 rs26835 chr16:2237549 C/T cg07587117 chr16:2239488 CASKIN1 0.39 7.56 0.38 3.98e-13 Height; LUSC cis rs968451 1.000 rs971964 chr22:39702473 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.69 8.9 0.44 3.55e-17 Primary biliary cholangitis; LUSC cis rs208520 0.690 rs3846808 chr6:66818604 A/G cg07460842 chr6:66804631 NA -1.14 -18.07 -0.7 2.26e-51 Exhaled nitric oxide output; LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg14004847 chr7:1930337 MAD1L1 -0.51 -7.76 -0.39 1.03e-13 Bipolar disorder and schizophrenia; LUSC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg25428297 chr7:1022841 CYP2W1 0.3 6.4 0.33 5.32e-10 Longevity;Endometriosis; LUSC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs3126085 0.877 rs6662450 chr1:152191709 C/G cg26876637 chr1:152193138 HRNR 0.43 6.24 0.32 1.34e-9 Atopic dermatitis; LUSC cis rs7903847 0.642 rs10882914 chr10:99142057 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.57e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs7107174 1.000 rs72931642 chr11:78037862 A/T cg02023728 chr11:77925099 USP35 0.47 6.76 0.35 6.01e-11 Testicular germ cell tumor; LUSC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg18099408 chr3:52552593 STAB1 0.44 7.77 0.39 9.83e-14 Bipolar disorder; LUSC cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg04455712 chr21:45112962 RRP1B 0.48 8.77 0.43 9.22e-17 Mean corpuscular volume; LUSC cis rs7851660 0.874 rs1443436 chr9:100631298 T/A cg13688889 chr9:100608707 NA -0.56 -8.91 -0.44 3.48e-17 Strep throat; LUSC trans rs1267813 1 rs1267813 chr11:133981075 G/C cg13056653 chr4:141538969 NA 0.28 6.17 0.32 1.92e-9 Schizophrenia; LUSC cis rs11971779 0.680 rs6961812 chr7:139043808 A/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs6500602 0.702 rs56895104 chr16:4548132 G/A cg08645402 chr16:4508243 NA 0.52 8.77 0.43 9.04e-17 Schizophrenia; LUSC trans rs61931739 0.500 rs10844844 chr12:34380350 G/T cg26384229 chr12:38710491 ALG10B 0.85 14.53 0.62 2.07e-37 Morning vs. evening chronotype; LUSC cis rs7191439 0.789 rs4598894 chr16:88776141 G/A cg02389323 chr16:88786976 FAM38A 1.17 10.06 0.48 5.79e-21 Plateletcrit; LUSC trans rs561341 1.000 rs554078 chr17:30330109 A/C cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs3540 0.533 rs12916560 chr15:91056259 A/C cg22089800 chr15:90895588 ZNF774 -0.64 -9.66 -0.47 1.27e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs259282 0.524 rs1559180 chr19:33127443 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.79 12.84 0.57 6e-31 Schizophrenia; LUSC trans rs10506458 1.000 rs17763435 chr12:63416511 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.14 14.2 0.61 3.95e-36 Hemostatic factors and hematological phenotypes; LUSC cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.63 9.89 0.48 2.11e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg03929089 chr4:120376271 NA 0.87 12.01 0.55 7.53e-28 Coronary artery disease; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.16 0.77 1.43e-67 Prudent dietary pattern; LUSC trans rs72792513 1.000 rs7602014 chr2:22920499 G/T cg05844895 chr16:88969569 CBFA2T3 0.5 6.2 0.32 1.69e-9 Hepatitis B; LUSC cis rs12579753 0.879 rs1922552 chr12:82158093 G/T cg21231944 chr12:82153410 PPFIA2 -0.4 -6.31 -0.33 8.73e-10 Resting heart rate; LUSC cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg11189052 chr15:85197271 WDR73 0.51 6.41 0.33 5.07e-10 Schizophrenia; LUSC cis rs7927771 0.524 rs12226431 chr11:47805856 G/A cg20307385 chr11:47447363 PSMC3 0.44 6.43 0.33 4.36e-10 Subjective well-being; LUSC cis rs191220855 1 rs191220855 chr2:200778130 A/G cg17644776 chr2:200775616 C2orf69 -0.51 -6.63 -0.34 1.34e-10 Chickenpox; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg13047869 chr3:10149882 C3orf24 0.56 7.72 0.39 1.37e-13 Alzheimer's disease; LUSC cis rs6582630 0.598 rs11182207 chr12:38477514 T/C cg26384229 chr12:38710491 ALG10B -0.55 -8.25 -0.41 3.63e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs17270561 0.609 rs4712968 chr6:25760344 T/C cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs4851254 0.961 rs11691486 chr2:100796182 T/C cg07810366 chr2:100720526 AFF3 -0.36 -5.75 -0.3 2.06e-8 Intelligence (multi-trait analysis); LUSC cis rs10791097 0.608 rs12363140 chr11:130744268 A/C cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4072705 0.646 rs7037254 chr9:127245412 C/T cg13476313 chr9:127244764 NR5A1 -0.36 -6.78 -0.35 5.4e-11 Menarche (age at onset); LUSC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.86 -0.4 5.18e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg11494091 chr17:61959527 GH2 0.64 13.4 0.59 4.47e-33 Prudent dietary pattern; LUSC cis rs9287719 0.967 rs10929688 chr2:10756650 T/C cg00105475 chr2:10696890 NA 0.38 6.36 0.33 6.75e-10 Prostate cancer; LUSC cis rs4692589 0.556 rs13133562 chr4:170965709 C/T cg19918862 chr4:170955249 NA 0.36 6.6 0.34 1.57e-10 Anxiety disorder; LUSC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg21880101 chr17:80066754 CCDC57 -0.31 -5.91 -0.31 8.52e-9 Life satisfaction; LUSC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg24324837 chr19:49891574 CCDC155 0.53 7.32 0.37 1.89e-12 Multiple sclerosis; LUSC cis rs2953145 0.617 rs7557192 chr2:241541274 T/C cg03371404 chr2:241525653 CAPN10 -0.41 -5.71 -0.3 2.45e-8 Bipolar disorder; LUSC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg06656553 chr16:89960601 TCF25 -0.63 -5.7 -0.3 2.68e-8 Skin colour saturation; LUSC cis rs7937682 0.575 rs1940391 chr11:111776891 G/A cg09085632 chr11:111637200 PPP2R1B 0.94 13.31 0.59 1.05e-32 Primary sclerosing cholangitis; LUSC cis rs13401104 0.796 rs10929170 chr2:237115591 A/G cg19324714 chr2:237145437 ASB18 0.43 5.65 0.3 3.43e-8 Educational attainment; LUSC cis rs67478160 0.609 rs1547604 chr14:104270659 A/T cg08213375 chr14:104286397 PPP1R13B 0.44 8.56 0.42 4.21e-16 Schizophrenia; LUSC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg17554472 chr22:41940697 POLR3H 0.48 5.91 0.31 8.32e-9 Cannabis dependence symptom count; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg08888203 chr3:10149979 C3orf24 0.46 6.81 0.35 4.62e-11 Alzheimer's disease; LUSC cis rs9611565 0.765 rs132906 chr22:41799767 G/C cg03806693 chr22:41940476 POLR3H 0.8 11.19 0.52 6.91e-25 Vitiligo; LUSC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs9287719 0.649 rs2160258 chr2:10717221 T/A cg00105475 chr2:10696890 NA 0.34 5.66 0.3 3.24e-8 Prostate cancer; LUSC cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg03146154 chr1:46216737 IPP -0.51 -7.35 -0.37 1.59e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg24060327 chr5:131705240 SLC22A5 -0.42 -6.79 -0.35 5.22e-11 Blood metabolite levels; LUSC cis rs9486719 0.948 rs6920913 chr6:96874297 A/G cg06623918 chr6:96969491 KIAA0776 0.77 9.83 0.47 3.42e-20 Migraine;Coronary artery disease; LUSC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg03433033 chr1:76189801 ACADM 0.78 10.89 0.51 7.61e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 12.99 0.58 1.6e-31 Platelet count; LUSC cis rs868036 1.000 rs4325504 chr15:68055570 A/G cg08079166 chr15:68083412 MAP2K5 -0.42 -8.62 -0.43 2.79e-16 Restless legs syndrome; LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg05025164 chr4:1340916 KIAA1530 -0.43 -6.53 -0.34 2.51e-10 Obesity-related traits; LUSC cis rs7512552 0.698 rs12028001 chr1:150407820 C/T cg15654264 chr1:150340011 RPRD2 0.61 10.13 0.48 3.39e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7584330 0.826 rs72620824 chr2:238381083 G/A cg16989719 chr2:238392110 NA -0.45 -7.12 -0.36 6.79e-12 Prostate cancer; LUSC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.38 0.46 1.04e-18 Monocyte percentage of white cells; LUSC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg12927641 chr6:109611667 NA -0.4 -6.92 -0.35 2.37e-11 Reticulocyte fraction of red cells; LUSC cis rs9311676 0.609 rs55646457 chr3:58415263 T/A cg13750441 chr3:58318267 PXK 0.35 6.86 0.35 3.38e-11 Systemic lupus erythematosus; LUSC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg11247378 chr22:39784982 NA -0.68 -13.63 -0.6 6.14e-34 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.9 0.31 9.02e-9 Menopause (age at onset); LUSC cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg09877947 chr5:131593287 PDLIM4 0.41 6.67 0.34 1.05e-10 Blood metabolite levels; LUSC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg00750074 chr16:89608354 SPG7 -0.45 -7.36 -0.37 1.47e-12 Multiple myeloma (IgH translocation); LUSC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.34e-8 Diabetic kidney disease; LUSC cis rs9549260 0.755 rs2721066 chr13:41156188 C/T cg21288729 chr13:41239152 FOXO1 -0.61 -9.64 -0.47 1.44e-19 Red blood cell count; LUSC cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg19875535 chr5:140030758 IK 0.47 7.68 0.39 1.78e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs1728785 1.000 rs1170433 chr16:68606081 A/G cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC trans rs2797160 1.000 rs1935772 chr6:125994708 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.63 -0.34 1.33e-10 Endometrial cancer; LUSC trans rs11098499 0.863 rs6534141 chr4:120485223 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.75e-10 Corneal astigmatism; LUSC cis rs7267979 1.000 rs397119 chr20:25440187 C/A cg08601574 chr20:25228251 PYGB 0.43 6.51 0.34 2.77e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg12963246 chr6:28129442 ZNF389 0.48 6.63 0.34 1.34e-10 Depression; LUSC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg04756594 chr16:24857601 SLC5A11 -0.49 -6.88 -0.35 2.92e-11 Intelligence (multi-trait analysis); LUSC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg06850241 chr22:41845214 NA -0.31 -5.66 -0.3 3.27e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9650315 0.714 rs7463962 chr8:57195932 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.13 0.36 6.25e-12 Height; LUSC cis rs10782582 0.609 rs72979226 chr1:76302222 C/A cg03433033 chr1:76189801 ACADM -0.43 -6.39 -0.33 5.51e-10 Daytime sleep phenotypes; LUSC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08704250 chr15:31115839 NA -0.47 -7.07 -0.36 9.16e-12 Huntington's disease progression; LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.14 0.41 7.83e-15 Prudent dietary pattern; LUSC cis rs1983170 0.808 rs6685254 chr1:92018415 T/C cg25838465 chr1:92012736 NA 0.42 5.86 0.31 1.09e-8 Eosinophil percentage of white cells; LUSC cis rs231513 0.954 rs425135 chr17:41984517 A/C cg26893861 chr17:41843967 DUSP3 -0.5 -5.82 -0.3 1.42e-8 Cognitive function; LUSC cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg06092702 chr1:163392909 NA -0.45 -7.43 -0.38 9.13e-13 Motion sickness; LUSC cis rs9815354 0.904 rs9848992 chr3:41875297 C/T cg03022575 chr3:42003672 ULK4 0.64 7.02 0.36 1.21e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.57 -0.38 3.57e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs10489525 0.599 rs11102879 chr1:115603504 C/T cg01522456 chr1:115632236 TSPAN2 0.5 7.33 0.37 1.8e-12 Autism; LUSC cis rs1790761 0.692 rs1269981 chr11:67334959 G/A cg00864171 chr11:67383662 NA 0.34 5.97 0.31 5.93e-9 Mean corpuscular volume; LUSC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg24642439 chr20:33292090 TP53INP2 0.64 10.01 0.48 8.11e-21 Coronary artery disease; LUSC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg09365446 chr1:150670422 GOLPH3L 0.52 7.56 0.38 3.81e-13 Melanoma; LUSC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg24531977 chr5:56204891 C5orf35 -1.08 -16.08 -0.66 1.79e-43 Initial pursuit acceleration; LUSC cis rs9287719 0.967 rs6735074 chr2:10734766 G/T cg03983476 chr2:10830698 NOL10 0.38 5.94 0.31 7.17e-9 Prostate cancer; LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 6.97 0.36 1.66e-11 Platelet count; LUSC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg14562523 chr21:43528734 C21orf128;UMODL1 -0.39 -6.36 -0.33 6.75e-10 IgG glycosylation; LUSC cis rs2839186 0.872 rs13052233 chr21:47707284 G/T cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC cis rs4699052 0.787 rs2169508 chr4:104066890 T/A cg16532752 chr4:104119610 CENPE -0.5 -7.09 -0.36 8.02e-12 Testicular germ cell tumor; LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg09177884 chr7:1199841 ZFAND2A -0.46 -5.99 -0.31 5.49e-9 Longevity;Endometriosis; LUSC cis rs3931020 0.657 rs277369 chr1:75234661 T/C cg10128416 chr1:75198403 TYW3;CRYZ -0.63 -8.39 -0.42 1.38e-15 Resistin levels; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.32 -0.37 1.89e-12 Bipolar disorder; LUSC cis rs72949976 0.646 rs11681232 chr2:214033002 G/A cg08319019 chr2:214017104 IKZF2 0.67 11.13 0.52 1.13e-24 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs6867032 1.000 rs16902318 chr5:2013568 A/G cg26168224 chr5:2018326 NA 0.81 15.07 0.64 1.65e-39 Gut microbiome composition (winter); LUSC cis rs9807841 0.592 rs1053007 chr19:10754400 A/G cg09936142 chr19:10668400 KRI1 -0.4 -6.47 -0.33 3.57e-10 Inflammatory skin disease; LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs61931739 0.817 rs2636084 chr12:34130210 G/A cg06521331 chr12:34319734 NA -0.37 -6.31 -0.33 8.65e-10 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs992157 0.798 rs2382817 chr2:219151218 A/C cg00012203 chr2:219082015 ARPC2 0.7 11.53 0.53 3.91e-26 Colorectal cancer; LUSC cis rs7608623 0.773 rs17507628 chr2:23921287 T/C cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs7100689 0.646 rs10736347 chr10:82134465 G/A cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg15448220 chr1:150897856 SETDB1 0.41 6.18 0.32 1.84e-9 Melanoma; LUSC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg06873352 chr17:61820015 STRADA 0.56 8.67 0.43 1.94e-16 Height; LUSC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg12463550 chr7:65579703 CRCP -0.55 -8.3 -0.41 2.62e-15 Aortic root size; LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg18876405 chr7:65276391 NA -0.55 -8.79 -0.43 8.32e-17 Aortic root size; LUSC cis rs2439831 0.867 rs689616 chr15:43761901 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs6457821 1.000 rs73415611 chr6:35437630 T/C cg06087101 chr6:35551932 FKBP5 0.62 5.71 0.3 2.51e-8 Height; LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.99 0.4 2.24e-14 Bipolar disorder; LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg08736216 chr1:53307985 ZYG11A 0.29 6.03 0.31 4.36e-9 Monocyte count; LUSC cis rs9815354 0.680 rs73075219 chr3:42038429 A/C cg03022575 chr3:42003672 ULK4 0.78 7.87 0.4 5.1e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg11494091 chr17:61959527 GH2 -0.75 -18.0 -0.7 4.07e-51 Prudent dietary pattern; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg07677032 chr17:61819896 STRADA -0.54 -8.99 -0.44 1.89e-17 Prudent dietary pattern; LUSC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 9.8 0.47 4.32e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1048238 0.506 rs10737911 chr1:16167855 C/T cg22431228 chr1:16359049 CLCNKA 0.37 7.86 0.4 5.22e-14 Systolic blood pressure; LUSC cis rs9378688 1.000 rs3800184 chr6:2211690 A/T cg12303981 chr6:2244766 GMDS 0.56 6.83 0.35 4.12e-11 Caudate nucleus volume; LUSC cis rs9297145 0.565 rs56132062 chr7:98778198 C/T cg05967295 chr7:98741636 SMURF1 -0.63 -9.7 -0.47 9.17e-20 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs3749237 0.964 rs1799843 chr3:49849723 G/A cg03060546 chr3:49711283 APEH 0.56 8.06 0.4 1.36e-14 Resting heart rate; LUSC cis rs1577917 0.771 rs9450319 chr6:86427325 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 10.37 0.49 4.94e-22 Response to antipsychotic treatment; LUSC cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg11266682 chr4:10021025 SLC2A9 0.51 9.35 0.46 1.35e-18 Bone mineral density; LUSC cis rs73198271 0.515 rs113524005 chr8:8634672 C/A cg01851573 chr8:8652454 MFHAS1 0.58 6.53 0.34 2.49e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2404602 0.669 rs9788684 chr15:77194838 A/T cg22467129 chr15:76604101 ETFA -0.44 -6.89 -0.35 2.82e-11 Blood metabolite levels; LUSC trans rs61931739 0.534 rs4365131 chr12:34053308 T/C cg13010199 chr12:38710504 ALG10B 0.53 7.95 0.4 2.88e-14 Morning vs. evening chronotype; LUSC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg23625390 chr15:77176239 SCAPER 0.5 7.75 0.39 1.11e-13 Blood metabolite levels; LUSC cis rs1670533 1.000 rs7685541 chr4:1058501 G/A cg27284194 chr4:1044797 NA 0.6 8.8 0.43 7.32e-17 Recombination rate (females); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12145289 chr11:65385911 PCNXL3 0.47 6.09 0.32 3.19e-9 Bipolar disorder and schizophrenia; LUSC cis rs4622329 0.615 rs7137913 chr12:102291377 C/T cg23541617 chr12:102225335 GNPTAB 0.27 6.21 0.32 1.55e-9 Systemic lupus erythematosus; LUSC cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.01 0.52 2.99e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.13 0.55 2.67e-28 Motion sickness; LUSC cis rs7106204 0.748 rs6484028 chr11:24222438 A/G ch.11.24196551F chr11:24239977 NA 1.14 14.29 0.62 1.8e-36 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11671005 0.737 rs11671033 chr19:58963669 G/T cg13877915 chr19:58951672 ZNF132 0.47 5.73 0.3 2.29e-8 Mean platelet volume; LUSC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg17971929 chr21:40555470 PSMG1 0.75 11.63 0.54 1.7e-26 Cognitive function; LUSC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg24531977 chr5:56204891 C5orf35 -0.95 -10.9 -0.51 7.15e-24 Type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02750587 chr1:85156370 SSX2IP 0.4 6.92 0.35 2.39e-11 Triglycerides; LUSC cis rs977987 0.771 rs8048527 chr16:75422054 C/A cg03315344 chr16:75512273 CHST6 0.47 8.98 0.44 1.95e-17 Dupuytren's disease; LUSC cis rs3087591 0.708 rs4794887 chr17:29649696 G/A cg24425628 chr17:29625626 OMG;NF1 0.46 6.87 0.35 3.09e-11 Hip circumference; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg26314531 chr2:26401878 FAM59B -0.7 -9.75 -0.47 6.29e-20 Gut microbiome composition (summer); LUSC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08704250 chr15:31115839 NA -0.47 -7.03 -0.36 1.19e-11 Huntington's disease progression; LUSC cis rs3733418 0.929 rs12512234 chr4:165908865 C/T cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -5.92 -0.31 7.89e-9 Obesity-related traits; LUSC cis rs9790314 0.690 rs1599389 chr3:160836006 G/A cg03342759 chr3:160939853 NMD3 -0.41 -6.78 -0.35 5.57e-11 Morning vs. evening chronotype; LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs11098499 0.604 rs10022185 chr4:120571765 C/G cg09307838 chr4:120376055 NA 0.7 9.88 0.48 2.23e-20 Corneal astigmatism; LUSC cis rs9788721 0.868 rs17486278 chr15:78867482 A/C cg18825076 chr15:78729989 IREB2 -0.47 -7.28 -0.37 2.37e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs75804782 0.521 rs72982590 chr2:239451826 T/C cg18131467 chr2:239335373 ASB1 -0.65 -6.01 -0.31 4.81e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs16966142 1.000 rs3890534 chr16:89835289 A/G cg04287289 chr16:89883240 FANCA -0.64 -5.69 -0.3 2.82e-8 Caffeine consumption; LUSC cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.71 0.7 5.89e-50 Chronic sinus infection; LUSC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg16339924 chr4:17578868 LAP3 0.63 9.88 0.48 2.3e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10751667 0.643 rs10902244 chr11:949981 A/G ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.69e-9 Alzheimer's disease (late onset); LUSC cis rs2235649 0.592 rs11647980 chr16:1959753 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.47 -5.95 -0.31 6.66e-9 Blood metabolite levels; LUSC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg02527881 chr3:46936655 PTH1R -0.45 -8.13 -0.41 8.66e-15 Colorectal cancer; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.98 -0.52 3.66e-24 Alzheimer's disease; LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17376456 0.542 rs17083380 chr5:93170476 C/G cg25358565 chr5:93447407 FAM172A -0.58 -8.26 -0.41 3.48e-15 Diabetic retinopathy; LUSC cis rs7582180 0.614 rs1030901 chr2:101007314 G/A cg08017756 chr2:100939284 LONRF2 -0.43 -8.06 -0.4 1.41e-14 Intelligence (multi-trait analysis); LUSC cis rs11051970 0.879 rs950079 chr12:32588620 A/G cg24626660 chr12:32551988 NA 0.33 5.66 0.3 3.2e-8 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs11098499 0.863 rs6853998 chr4:120475860 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg06484146 chr7:12443880 VWDE -0.72 -7.25 -0.37 2.84e-12 Coronary artery disease; LUSC cis rs17490626 0.533 rs12771890 chr10:71189483 T/A cg14388049 chr10:71211838 TSPAN15 -0.32 -5.87 -0.31 1.04e-8 Thrombosis; LUSC cis rs7107174 1.000 rs10793302 chr11:78040961 C/T cg02023728 chr11:77925099 USP35 0.47 7.11 0.36 7.28e-12 Testicular germ cell tumor; LUSC cis rs11971779 0.680 rs10242419 chr7:139089380 A/G cg07862535 chr7:139043722 LUC7L2 -0.58 -7.32 -0.37 1.86e-12 Diisocyanate-induced asthma; LUSC trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg03929089 chr4:120376271 NA -0.79 -10.53 -0.5 1.35e-22 Coronary artery disease; LUSC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs2281845 1.000 rs2281845 chr1:201081943 C/T cg22815214 chr1:201083145 CACNA1S 0.56 9.82 0.47 3.69e-20 Permanent tooth development; LUSC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg00310523 chr12:86230176 RASSF9 0.51 9.61 0.47 1.8e-19 Major depressive disorder; LUSC trans rs12579753 0.871 rs10862362 chr12:82199383 T/G cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs6430585 0.528 rs309167 chr2:136669264 C/T cg07169764 chr2:136633963 MCM6 1.13 17.57 0.69 2.12e-49 Corneal structure; LUSC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.03 0.55 6.07e-28 Chronic sinus infection; LUSC cis rs4888262 0.526 rs6564145 chr16:74621129 G/A cg01733217 chr16:74700730 RFWD3 0.8 13.42 0.59 3.86e-33 Testicular germ cell tumor; LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg03354898 chr7:1950403 MAD1L1 -0.33 -6.22 -0.32 1.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg04369109 chr6:150039330 LATS1 -0.51 -7.32 -0.37 1.81e-12 Lung cancer; LUSC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -8.57 -0.42 3.99e-16 Personality dimensions; LUSC cis rs9443645 0.509 rs9352668 chr6:79572678 A/G cg09184832 chr6:79620586 NA -0.44 -6.95 -0.36 1.89e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg11764359 chr7:65958608 NA 0.69 11.09 0.52 1.48e-24 Aortic root size; LUSC cis rs7769051 1.000 rs58832890 chr6:133127139 C/T cg07930552 chr6:133119739 C6orf192 0.84 10.54 0.5 1.29e-22 Type 2 diabetes nephropathy; LUSC cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.9 0.31 8.84e-9 Rheumatoid arthritis; LUSC cis rs4474633 1 rs4474633 chr15:49260601 A/G cg19135536 chr15:49267992 NA -0.45 -6.61 -0.34 1.54e-10 Major depressive disorder; LUSC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg15445000 chr17:37608096 MED1 -0.39 -6.7 -0.34 8.93e-11 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2758596 0.850 rs2842879 chr1:156163695 G/T cg25208724 chr1:156163844 SLC25A44 0.79 6.57 0.34 1.94e-10 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs7799006 0.582 rs7781284 chr7:2339405 G/T cg08027265 chr7:2291960 NA -0.47 -8.12 -0.41 9.28e-15 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9430161 0.564 rs12081176 chr1:11034145 T/C cg27631724 chr1:11040367 C1orf127 0.54 9.4 0.46 8.69e-19 Ewing sarcoma; LUSC cis rs1775715 0.769 rs2799030 chr10:32172935 G/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.66 0.34 1.14e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11625487 0.609 rs78677337 chr14:77966223 G/A cg16049707 chr14:77965284 ISM2 -0.64 -6.78 -0.35 5.31e-11 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 14.24 0.61 2.72e-36 Platelet count; LUSC cis rs9467773 0.596 rs3001369 chr6:26670969 C/T cg09904177 chr6:26538194 HMGN4 0.64 11.07 0.52 1.85e-24 Intelligence (multi-trait analysis); LUSC cis rs8017423 0.967 rs2401875 chr14:90688451 A/G cg14092571 chr14:90743983 NA -0.36 -5.9 -0.31 8.76e-9 Mortality in heart failure; LUSC trans rs9929218 0.953 rs11075696 chr16:68731365 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -12.64 -0.57 3.34e-30 Colorectal cancer; LUSC cis rs2303282 0.716 rs1478478 chr16:56402531 C/A cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs4595586 0.545 rs2388176 chr12:39372357 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.08e-9 Morning vs. evening chronotype; LUSC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg09359103 chr1:154839909 KCNN3 -0.43 -8.18 -0.41 6.13e-15 Schizophrenia; LUSC cis rs6500602 0.627 rs863501 chr16:4588394 G/C cg08645402 chr16:4508243 NA -0.46 -7.26 -0.37 2.66e-12 Schizophrenia; LUSC cis rs13006833 0.765 rs291431 chr2:191199530 G/A cg21644426 chr2:191273491 MFSD6 0.46 6.47 0.33 3.45e-10 Urinary metabolites; LUSC cis rs9300255 0.739 rs1533703 chr12:123742093 T/G cg05973401 chr12:123451056 ABCB9 0.52 6.43 0.33 4.29e-10 Neutrophil percentage of white cells; LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18404041 chr3:52824283 ITIH1 -0.63 -12.21 -0.56 1.38e-28 Bipolar disorder; LUSC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg11663144 chr21:46675770 NA -0.43 -7.65 -0.39 2.21e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg19729930 chr2:74357872 NA 0.94 18.09 0.7 1.76e-51 Gestational age at birth (maternal effect); LUSC cis rs1577917 0.958 rs1337843 chr6:86675545 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.23 -0.32 1.43e-9 Response to antipsychotic treatment; LUSC trans rs9329221 0.512 rs7843924 chr8:9976540 C/T cg21775007 chr8:11205619 TDH 0.44 6.26 0.32 1.19e-9 Neuroticism; LUSC cis rs9807989 0.811 rs4485585 chr2:102970759 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs4666002 0.956 rs10179872 chr2:27778572 G/A cg27432699 chr2:27873401 GPN1 0.41 5.7 0.3 2.69e-8 Phospholipid levels (plasma); LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg04369109 chr6:150039330 LATS1 -0.56 -8.25 -0.41 3.68e-15 Lung cancer; LUSC cis rs11098499 0.865 rs1112817 chr4:120297800 T/C cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg22834771 chr12:69754056 YEATS4 -0.49 -7.41 -0.38 1.02e-12 Blood protein levels; LUSC cis rs1775715 0.678 rs2778649 chr10:32146803 C/G cg26784012 chr10:32216390 ARHGAP12 0.45 7.51 0.38 5.36e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs611744 0.647 rs615126 chr8:109247619 C/T cg21045802 chr8:109455806 TTC35 0.43 6.59 0.34 1.68e-10 Dupuytren's disease; LUSC cis rs9790314 0.502 rs2404342 chr3:161092562 C/T cg03342759 chr3:160939853 NMD3 -0.52 -7.23 -0.37 3.37e-12 Morning vs. evening chronotype; LUSC cis rs7911264 0.739 rs10882091 chr10:94374377 C/T cg25093409 chr10:94429542 NA 0.36 6.21 0.32 1.59e-9 Inflammatory bowel disease; LUSC cis rs2835872 0.828 rs73220494 chr21:38989276 C/T cg20424643 chr21:39039972 KCNJ6 0.36 5.69 0.3 2.84e-8 Electroencephalographic traits in alcoholism; LUSC trans rs72674100 1.000 rs7694339 chr4:97968342 C/T cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11644478 chr21:40555479 PSMG1 -0.82 -14.41 -0.62 6.05e-37 Cognitive function; LUSC cis rs4906332 1.000 rs13987 chr14:103969909 A/G cg04998671 chr14:104000505 TRMT61A -0.49 -7.76 -0.39 1.07e-13 Coronary artery disease; LUSC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg18131467 chr2:239335373 ASB1 1.05 25.01 0.81 1.55e-78 Multiple system atrophy; LUSC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg02038168 chr22:39784481 NA 0.41 6.16 0.32 2.1e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg22638593 chr5:131593259 PDLIM4 0.39 5.76 0.3 1.9e-8 Breast cancer; LUSC cis rs950169 0.922 rs4842939 chr15:84827966 C/T cg12863693 chr15:85201151 NMB -0.27 -5.9 -0.31 9e-9 Schizophrenia; LUSC cis rs11190604 1.000 rs10883506 chr10:102289743 C/G cg07080220 chr10:102295463 HIF1AN 0.7 9.4 0.46 8.73e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg15147215 chr3:52552868 STAB1 -0.31 -6.08 -0.32 3.28e-9 Bipolar disorder; LUSC cis rs887829 0.641 rs10167119 chr2:234589312 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -6.55 -0.34 2.23e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs12541635 0.677 rs6997487 chr8:106965511 A/C cg10147462 chr8:107024639 NA 0.64 12.92 0.58 3.03e-31 Age of smoking initiation; LUSC cis rs6840360 0.642 rs1470281 chr4:152431552 A/G cg20465933 chr4:152376761 FAM160A1 0.33 5.91 0.31 8.36e-9 Intelligence (multi-trait analysis); LUSC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg07424592 chr7:64974309 NA 0.69 6.07 0.32 3.41e-9 Diabetic kidney disease; LUSC cis rs2832077 1.000 rs12329875 chr21:30137796 C/T cg08807101 chr21:30365312 RNF160 -0.51 -6.44 -0.33 4.27e-10 Cognitive test performance; LUSC cis rs17685 0.712 rs10275521 chr7:75770972 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2898681 0.581 rs731073 chr4:53680090 A/G cg00338735 chr4:53728038 RASL11B 0.42 5.77 0.3 1.78e-8 Optic nerve measurement (cup area); LUSC trans rs7829975 0.714 rs60315134 chr8:8670599 A/G cg21775007 chr8:11205619 TDH 0.43 6.2 0.32 1.69e-9 Mood instability; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg14004847 chr7:1930337 MAD1L1 -0.51 -7.83 -0.39 6.51e-14 Bipolar disorder and schizophrenia; LUSC trans rs10771431 1.000 rs11611670 chr12:9385535 C/T cg27600084 chr12:12264075 NA 0.49 7.18 0.37 4.46e-12 Breast size; LUSC cis rs911555 0.723 rs7144010 chr14:103869869 G/A cg12935359 chr14:103987150 CKB 0.65 10.54 0.5 1.31e-22 Intelligence (multi-trait analysis); LUSC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg00033643 chr7:134001901 SLC35B4 0.46 7.25 0.37 2.87e-12 Mean platelet volume; LUSC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11890956 chr21:40555474 PSMG1 -0.91 -16.52 -0.67 3.02e-45 Cognitive function; LUSC cis rs2573652 0.722 rs11636047 chr15:100543341 A/G cg00587665 chr15:100533223 ADAMTS17 -0.35 -6.27 -0.32 1.09e-9 Height; LUSC cis rs1348850 0.872 rs12991272 chr2:178457339 T/C cg22681709 chr2:178499509 PDE11A -0.47 -8.43 -0.42 1.02e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11098499 0.909 rs79704848 chr4:120309351 T/A cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs6681460 0.546 rs10889648 chr1:67168182 T/C cg02459107 chr1:67143332 SGIP1 0.33 5.88 0.31 9.9e-9 Presence of antiphospholipid antibodies; LUSC cis rs1524927 0.966 rs7812179 chr7:96354770 A/G cg03808172 chr7:96339361 SHFM1 0.43 6.53 0.34 2.48e-10 Total body bone mineral density; LUSC cis rs662064 0.962 rs622623 chr1:10555257 C/T cg20482658 chr1:10539492 PEX14 -0.32 -6.61 -0.34 1.54e-10 Asthma; LUSC cis rs4803468 1.000 rs284663 chr19:41932612 C/T cg09537434 chr19:41945824 ATP5SL -0.96 -16.5 -0.67 3.73e-45 Height; LUSC cis rs4718428 1.000 rs12534637 chr7:66327654 G/C cg11764359 chr7:65958608 NA 0.44 6.29 0.33 9.94e-10 Corneal structure; LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg20887711 chr4:1340912 KIAA1530 -0.5 -7.5 -0.38 5.93e-13 Obesity-related traits; LUSC cis rs3820928 0.874 rs7605032 chr2:227847630 T/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.58 -0.38 3.4e-13 Pulmonary function; LUSC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -13.41 -0.59 4.27e-33 Hemoglobin concentration; LUSC cis rs2120019 0.567 rs8037152 chr15:75156996 A/T cg17294928 chr15:75287854 SCAMP5 -0.72 -8.16 -0.41 6.7e-15 Blood trace element (Zn levels); LUSC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg12311346 chr5:56204834 C5orf35 -0.58 -8.98 -0.44 1.99e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs17604090 0.793 rs17136535 chr7:29689158 C/T cg19413766 chr7:29689036 LOC646762 -0.56 -7.01 -0.36 1.36e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg00677455 chr12:58241039 CTDSP2 0.71 10.73 0.51 2.77e-23 Intelligence (multi-trait analysis); LUSC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.86 -13.72 -0.6 2.77e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4888262 0.526 rs8062959 chr16:74627628 T/C cg01733217 chr16:74700730 RFWD3 0.8 13.43 0.59 3.48e-33 Testicular germ cell tumor; LUSC cis rs7180079 0.563 rs2733381 chr15:64857043 T/C cg08069370 chr15:64387884 SNX1 0.51 5.71 0.3 2.47e-8 Monocyte count; LUSC cis rs2456568 0.548 rs6483280 chr11:93661592 T/C cg26875233 chr11:93583750 C11orf90 -0.31 -6.04 -0.31 4.07e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs11158026 0.757 rs56164809 chr14:55400212 A/G cg04306507 chr14:55594613 LGALS3 0.34 6.43 0.33 4.48e-10 Parkinson's disease; LUSC cis rs3099143 1.000 rs35645941 chr15:77140302 C/T cg21673338 chr15:77095150 SCAPER -0.8 -7.36 -0.37 1.41e-12 Recalcitrant atopic dermatitis; LUSC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 9.09 0.45 8.97e-18 Tonsillectomy; LUSC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg25019033 chr10:957182 NA -0.51 -6.36 -0.33 6.76e-10 Eosinophil percentage of granulocytes; LUSC cis rs9858542 0.953 rs11715915 chr3:49455330 A/G cg07274523 chr3:49395745 GPX1 -0.62 -8.83 -0.43 6.23e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs611744 0.647 rs2594358 chr8:109256018 A/G cg18478394 chr8:109455254 TTC35 0.43 6.65 0.34 1.22e-10 Dupuytren's disease; LUSC trans rs895636 0.898 rs10205310 chr2:45188646 A/G cg01331992 chr9:19379118 RPS6 0.48 5.98 0.31 5.67e-9 Metabolite levels;Fasting plasma glucose; LUSC cis rs826838 0.616 rs7977357 chr12:38626008 C/G cg26384229 chr12:38710491 ALG10B -0.56 -8.45 -0.42 8.99e-16 Heart rate; LUSC cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.52e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs9815354 0.767 rs73069245 chr3:41951452 G/A cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg27286337 chr10:134555280 INPP5A -0.87 -11.31 -0.53 2.45e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7949030 0.653 rs2516634 chr11:62367186 G/A cg11742103 chr11:62369870 EML3;MTA2 -0.53 -8.87 -0.44 4.42e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7589342 0.839 rs7589790 chr2:106433909 C/G cg16077055 chr2:106428750 NCK2 -0.35 -6.44 -0.33 4.18e-10 Addiction; LUSC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.53e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg21699342 chr2:239360505 ASB1 0.55 10.14 0.48 3.17e-21 Multiple system atrophy; LUSC cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg25801113 chr15:45476975 SHF 0.35 7.08 0.36 8.74e-12 Uric acid levels; LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.84 -0.3 1.22e-8 Platelet count; LUSC cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg09184832 chr6:79620586 NA -0.41 -6.32 -0.33 8.39e-10 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs12354411 chr10:102294537 G/A cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg16339924 chr4:17578868 LAP3 0.47 7.37 0.37 1.34e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7917772 0.636 rs7079231 chr10:104527341 A/G cg05855489 chr10:104503620 C10orf26 -0.53 -7.28 -0.37 2.44e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2742234 0.541 rs11238481 chr10:43719286 A/G cg15436174 chr10:43711423 RASGEF1A 0.44 7.06 0.36 9.75e-12 Hirschsprung disease; LUSC cis rs9549260 0.604 rs9532587 chr13:41302694 A/T cg21288729 chr13:41239152 FOXO1 0.56 6.37 0.33 6.19e-10 Red blood cell count; LUSC cis rs7674212 0.512 rs2720462 chr4:104056210 T/G cg16532752 chr4:104119610 CENPE -0.47 -6.66 -0.34 1.1e-10 Type 2 diabetes; LUSC cis rs11122272 0.766 rs2808608 chr1:231543175 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.69 -10.9 -0.51 6.89e-24 Hemoglobin concentration; LUSC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg22601191 chr20:60968625 CABLES2 -0.45 -6.29 -0.33 9.93e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg13683864 chr3:40499215 RPL14 -0.93 -15.94 -0.66 5.93e-43 Renal cell carcinoma; LUSC cis rs7098414 0.511 rs7898787 chr10:82156042 G/A cg01528321 chr10:82214614 TSPAN14 0.62 9.31 0.45 1.74e-18 Post bronchodilator FEV1; LUSC trans rs7829975 0.623 rs10087493 chr8:8373557 A/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.58 -0.34 1.78e-10 Mood instability; LUSC cis rs7216064 1.000 rs55939964 chr17:65869297 G/A cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg09839279 chr12:125627357 AACS -0.33 -6.01 -0.31 4.96e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs17407555 0.738 rs55731306 chr4:10067885 G/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.26 -0.32 1.19e-9 Schizophrenia (age at onset); LUSC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg13114125 chr14:105738426 BRF1 -0.93 -16.05 -0.66 2.23e-43 Mean platelet volume;Platelet distribution width; LUSC trans rs61931739 0.517 rs11612493 chr12:34114272 A/C cg13010199 chr12:38710504 ALG10B 0.52 8.0 0.4 2.01e-14 Morning vs. evening chronotype; LUSC cis rs7903847 0.642 rs7088410 chr10:99135539 G/T cg06359132 chr10:99160096 RRP12 -0.24 -5.66 -0.3 3.33e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs11098499 0.909 rs10017335 chr4:120381523 C/G cg24375607 chr4:120327624 NA -0.77 -11.67 -0.54 1.25e-26 Corneal astigmatism; LUSC cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs13256369 0.789 rs13282500 chr8:8568489 A/T cg17143192 chr8:8559678 CLDN23 0.55 8.03 0.4 1.65e-14 Obesity-related traits; LUSC cis rs2486288 0.656 rs8037583 chr15:45546378 A/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.8 -0.39 7.79e-14 Glomerular filtration rate; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg17720231 chr1:159915374 IGSF9 -0.37 -6.42 -0.33 4.56e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2637266 0.935 rs7393727 chr10:78365977 T/A cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.61e-12 Pulmonary function; LUSC cis rs6964587 1.000 rs3753109 chr7:91630001 G/C cg01689657 chr7:91764605 CYP51A1 0.32 5.78 0.3 1.76e-8 Breast cancer; LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs9788682 0.747 rs12101809 chr15:78779801 C/T cg18825076 chr15:78729989 IREB2 0.44 6.06 0.31 3.7e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7617480 0.617 rs7610519 chr3:48746427 C/G cg21141812 chr3:48556323 PFKFB4 0.34 6.2 0.32 1.68e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg21782813 chr7:2030301 MAD1L1 -0.54 -9.16 -0.45 5.26e-18 Bipolar disorder and schizophrenia; LUSC cis rs7493 0.950 rs11977702 chr7:95029767 C/T cg04871131 chr7:94954202 PON1 -0.37 -5.9 -0.31 8.9e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.33 -5.82 -0.3 1.4e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg00343986 chr7:65444356 GUSB 0.43 6.51 0.34 2.7e-10 Aortic root size; LUSC cis rs4423214 1.000 rs12806844 chr11:71170770 G/A cg05163923 chr11:71159392 DHCR7 0.74 11.07 0.52 1.79e-24 Vitamin D levels; LUSC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg06671706 chr8:8559999 CLDN23 0.5 6.68 0.34 9.98e-11 Obesity-related traits; LUSC trans rs1927790 0.759 rs12583996 chr13:96991702 G/A cg03198741 chr6:1003969 LOC285768 -0.4 -5.99 -0.31 5.57e-9 Body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17608500 chr1:154955711 FLAD1 0.42 6.35 0.33 7.18e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs34779708 0.931 rs12773169 chr10:35366462 G/C cg03585969 chr10:35415529 CREM 0.6 8.88 0.44 4.32e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs16976116 0.901 rs73409851 chr15:55502516 G/A cg11288833 chr15:55489084 RSL24D1 0.51 6.13 0.32 2.5e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9527 0.830 rs10883790 chr10:104640955 A/C cg04362960 chr10:104952993 NT5C2 0.65 9.45 0.46 6.2e-19 Arsenic metabolism; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg16647868 chr5:131706066 SLC22A5 0.35 5.87 0.31 1.03e-8 Blood metabolite levels; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg16325326 chr1:53192061 ZYG11B 0.75 12.8 0.57 8.33e-31 Monocyte count; LUSC cis rs13006833 0.668 rs291447 chr2:191177005 A/C cg21644426 chr2:191273491 MFSD6 0.43 6.14 0.32 2.39e-9 Urinary metabolites; LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18402987 chr7:1209562 NA 0.38 5.84 0.3 1.22e-8 Longevity;Endometriosis; LUSC trans rs236907 0.859 rs36080557 chr1:171764003 A/G cg13482142 chr2:234261155 NA 0.49 6.17 0.32 1.95e-9 Mean platelet volume; LUSC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg15605315 chr1:45957053 TESK2 0.46 7.33 0.37 1.78e-12 High light scatter reticulocyte count; LUSC cis rs12791968 0.765 rs12794846 chr11:44998943 C/T cg11846598 chr11:44996168 LOC221122 0.6 8.57 0.42 3.94e-16 Inhibitory control; LUSC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.97 0.36 1.66e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6982240 0.514 rs10088801 chr8:142275801 T/C cg27411547 chr8:142287226 NA -0.47 -8.02 -0.4 1.77e-14 Tonsillectomy; LUSC cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg05340658 chr4:99064831 C4orf37 0.68 11.58 0.54 2.61e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs12760731 0.623 rs71628283 chr1:178458450 G/A cg00404053 chr1:178313656 RASAL2 0.63 6.67 0.34 1.09e-10 Obesity-related traits; LUSC cis rs16937 0.711 rs3851289 chr1:205149657 G/T cg00857998 chr1:205179979 DSTYK 0.46 6.47 0.33 3.46e-10 Schizophrenia; LUSC cis rs611744 0.870 rs2212703 chr8:109198401 G/C cg18478394 chr8:109455254 TTC35 0.4 5.95 0.31 6.61e-9 Dupuytren's disease; LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg04155289 chr7:94953770 PON1 -0.47 -9.47 -0.46 5.37e-19 Paraoxonase activity; LUSC trans rs208520 0.690 rs851459 chr6:66813989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.68 -0.7 7.51e-50 Exhaled nitric oxide output; LUSC cis rs6732160 0.691 rs11886257 chr2:73416873 C/T cg24220031 chr2:73402428 NA -0.23 -5.76 -0.3 1.9e-8 Intelligence (multi-trait analysis); LUSC cis rs7119 0.717 rs7180732 chr15:77829921 G/A cg27398640 chr15:77910606 LINGO1 -0.32 -6.8 -0.35 4.98e-11 Type 2 diabetes; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.35 0.42 1.82e-15 Prudent dietary pattern; LUSC cis rs1044826 1.000 rs13092935 chr3:139175464 C/T cg00490450 chr3:139108681 COPB2 0.5 6.67 0.34 1.04e-10 Obesity-related traits; LUSC cis rs422421 1.000 rs422421 chr5:176517326 A/G cg00618323 chr5:176515533 FGFR4 0.37 5.69 0.3 2.74e-8 Height; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg18404041 chr3:52824283 ITIH1 -0.7 -13.11 -0.58 6.02e-32 Bipolar disorder; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02475777 chr4:1388615 CRIPAK 0.58 9.03 0.44 1.42e-17 Longevity; LUSC cis rs5770917 1.000 rs2073604 chr22:51008925 G/A cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.89 -0.31 9.54e-9 Narcolepsy; LUSC trans rs6951245 1.000 rs11770909 chr7:1086716 G/A cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9914988 0.778 rs9907185 chr17:27122414 C/T cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg27170947 chr2:26402098 FAM59B -0.63 -9.24 -0.45 3.04e-18 Gut microbiome composition (summer); LUSC cis rs11758351 1.000 rs79868973 chr6:26189312 C/G cg01420254 chr6:26195488 NA 0.67 7.5 0.38 5.77e-13 Gout;Renal underexcretion gout; LUSC cis rs71403859 0.554 rs12920245 chr16:72029069 C/A cg08717414 chr16:71523259 ZNF19 -0.7 -5.84 -0.3 1.21e-8 Post bronchodilator FEV1; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg26338869 chr17:61819248 STRADA 0.42 6.06 0.31 3.7e-9 Prudent dietary pattern; LUSC trans rs8073060 0.521 rs225254 chr17:33953384 G/A cg19694781 chr19:47549865 TMEM160 -0.58 -9.38 -0.46 1.03e-18 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs295140 1.000 rs10931899 chr2:201176901 A/G cg04283868 chr2:201171347 SPATS2L -0.42 -6.29 -0.33 9.83e-10 QT interval; LUSC cis rs3862030 0.810 rs11593710 chr10:104328719 A/C cg22532475 chr10:104410764 TRIM8 0.25 5.96 0.31 6.52e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs61931739 0.517 rs10844830 chr12:34308133 C/T cg06521331 chr12:34319734 NA -0.52 -9.1 -0.45 8.63e-18 Morning vs. evening chronotype; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg25767906 chr1:53392781 SCP2 0.71 14.08 0.61 1.12e-35 Monocyte count; LUSC cis rs4654899 1.000 rs2271115 chr1:21295864 C/T cg01072550 chr1:21505969 NA -0.55 -8.41 -0.42 1.23e-15 Superior frontal gyrus grey matter volume; LUSC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg12334488 chr2:20871173 GDF7 -0.34 -6.18 -0.32 1.82e-9 Abdominal aortic aneurysm; LUSC cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.2e-17 Motion sickness; LUSC cis rs9039 0.959 rs4985101 chr16:9194963 T/C cg08831531 chr16:9218945 NA -0.56 -8.76 -0.43 1.01e-16 Menopause (age at onset); LUSC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs6736093 0.796 rs4848971 chr2:112790446 C/T cg12686935 chr2:112915763 FBLN7 -0.39 -6.28 -0.32 1.08e-9 Coronary artery disease; LUSC cis rs1957429 0.808 rs11158564 chr14:65335082 G/A cg23373153 chr14:65346875 NA 0.97 11.0 0.52 3.19e-24 Pediatric areal bone mineral density (radius); LUSC cis rs7119 0.651 rs8025968 chr15:77839616 C/T cg27398640 chr15:77910606 LINGO1 -0.33 -6.63 -0.34 1.32e-10 Type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21902160 chr7:29689075 LOC646762 0.49 6.17 0.32 1.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg16928487 chr17:17741425 SREBF1 0.48 9.72 0.47 7.76e-20 Total body bone mineral density; LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg08742575 chr21:47604166 C21orf56 0.48 7.27 0.37 2.5e-12 Testicular germ cell tumor; LUSC cis rs453301 0.686 rs28665409 chr8:8869277 G/A cg15556689 chr8:8085844 FLJ10661 -0.62 -9.57 -0.46 2.49e-19 Joint mobility (Beighton score); LUSC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.74 11.67 0.54 1.26e-26 Hip circumference adjusted for BMI; LUSC cis rs2235642 0.717 rs2236269 chr16:1652614 T/A cg26528668 chr16:1614120 IFT140 0.41 6.77 0.35 5.98e-11 Coronary artery disease; LUSC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg27572855 chr1:25598939 RHD 0.45 8.23 0.41 4.38e-15 Erythrocyte sedimentation rate; LUSC cis rs9796 0.621 rs2899013 chr15:41492283 G/T cg18705301 chr15:41695430 NDUFAF1 -0.51 -8.99 -0.44 1.88e-17 Menopause (age at onset); LUSC trans rs60843830 1.000 rs7566279 chr2:281178 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 10.79 0.51 1.78e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs11122272 0.735 rs2749708 chr1:231529610 G/A cg06096015 chr1:231504339 EGLN1 0.58 10.45 0.5 2.68e-22 Hemoglobin concentration; LUSC cis rs6665290 0.904 rs6677602 chr1:227187838 G/T cg10327440 chr1:227177885 CDC42BPA -1.1 -27.19 -0.83 1.14e-86 Myeloid white cell count; LUSC cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg04025307 chr7:1156635 C7orf50 0.43 5.8 0.3 1.51e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg18230493 chr5:56204884 C5orf35 0.62 9.15 0.45 5.73e-18 Coronary artery disease; LUSC cis rs4595586 0.545 rs9668716 chr12:39378833 G/T cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs17270561 0.609 rs4712964 chr6:25740822 A/T cg16482183 chr6:26056742 HIST1H1C 0.64 9.18 0.45 4.59e-18 Iron status biomarkers; LUSC trans rs6601327 0.575 rs6994574 chr8:9578255 G/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.6 -0.34 1.66e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs28655083 1.000 rs8045658 chr16:77056343 A/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.42 -6.27 -0.32 1.12e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs56804039 1.000 rs58361948 chr8:8380995 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -6.27 -0.32 1.12e-9 Cervical cancer; LUSC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg10792982 chr14:105748885 BRF1 0.49 8.88 0.44 4.19e-17 Mean platelet volume;Platelet distribution width; LUSC trans rs4332037 0.624 rs11766944 chr7:1888051 G/A cg25206134 chr2:45395956 NA 0.51 5.98 0.31 5.87e-9 Bipolar disorder; LUSC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.71 -0.34 8.52e-11 Alzheimer's disease (late onset); LUSC cis rs1950626 0.827 rs35829821 chr14:101409763 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.42 7.46 0.38 7.73e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs6961069 0.743 rs1054517 chr7:80285003 C/T cg04458919 chr7:80252533 CD36 -0.35 -6.14 -0.32 2.28e-9 Platelet count; LUSC cis rs4664308 1.000 rs6719686 chr2:160908292 T/G cg03641300 chr2:160917029 PLA2R1 -0.66 -11.25 -0.52 4.06e-25 Idiopathic membranous nephropathy; LUSC cis rs4689388 0.926 rs12508672 chr4:6287965 G/A cg00701064 chr4:6280414 WFS1 0.58 13.96 0.61 3.27e-35 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6084875 0.840 rs2065705 chr20:4719407 A/G cg07258627 chr20:4721683 PRNT 0.34 6.21 0.32 1.6e-9 Systemic lupus erythematosus; LUSC cis rs6546537 0.911 rs62133968 chr2:69891910 C/T cg10773587 chr2:69614142 GFPT1 -0.53 -8.12 -0.41 9.2e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs73416724 0.858 rs4466248 chr6:43279652 T/C cg26312998 chr6:43337775 ZNF318 -0.53 -6.14 -0.32 2.38e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg10792982 chr14:105748885 BRF1 0.52 9.29 0.45 2.08e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs2652834 0.808 rs11071723 chr15:63355275 A/T cg05507819 chr15:63340323 TPM1 0.69 8.66 0.43 2.05e-16 HDL cholesterol; LUSC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg04518342 chr5:131593106 PDLIM4 0.34 6.18 0.32 1.92e-9 Blood metabolite levels; LUSC cis rs568617 0.953 rs658938 chr11:65651830 A/G cg19792802 chr11:65647270 CTSW -0.41 -6.23 -0.32 1.38e-9 Crohn's disease; LUSC cis rs13064411 0.735 rs6778800 chr3:113149236 A/G cg18753928 chr3:113234510 CCDC52 -0.44 -6.76 -0.35 6.31e-11 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg18252515 chr7:66147081 NA -1.22 -13.8 -0.6 1.31e-34 Diabetic kidney disease; LUSC cis rs9814567 1.000 rs6772896 chr3:134203347 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.58 -0.6 9.26e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1018836 0.798 rs4735295 chr8:91671608 C/A cg16814680 chr8:91681699 NA -0.98 -18.51 -0.71 3.7e-53 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs617219 0.819 rs10074882 chr5:78602863 C/T cg24856658 chr5:78533917 JMY -0.31 -6.23 -0.32 1.39e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs7954584 0.616 rs10743185 chr12:122356435 G/A cg21016266 chr12:122356598 WDR66 0.54 7.68 0.39 1.82e-13 Mean corpuscular volume; LUSC trans rs11098499 0.955 rs13129661 chr4:120152909 C/G cg25214090 chr10:38739885 LOC399744 0.45 6.49 0.33 3.1e-10 Corneal astigmatism; LUSC cis rs559928 0.606 rs78038516 chr11:63978067 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 7.68 0.39 1.82e-13 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg25208724 chr1:156163844 SLC25A44 -1.07 -25.74 -0.82 2.75e-81 Testicular germ cell tumor; LUSC trans rs11700980 0.551 rs2251445 chr21:30109148 G/A cg14791747 chr16:20752902 THUMPD1 0.56 6.1 0.32 2.88e-9 QRS complex (12-leadsum); LUSC cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.74 0.84 1.09e-88 Chronic sinus infection; LUSC cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg16586182 chr3:47516702 SCAP 0.5 7.81 0.39 7.26e-14 Colorectal cancer; LUSC cis rs12940923 1.000 rs12452417 chr17:56367202 G/A cg19466818 chr17:56409534 MIR142 -0.39 -6.87 -0.35 3.19e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg19774624 chr17:42201019 HDAC5 -0.8 -13.44 -0.59 3.23e-33 Total body bone mineral density; LUSC cis rs3741151 1.000 rs76570090 chr11:73066321 A/T cg17517138 chr11:73019481 ARHGEF17 1.09 9.0 0.44 1.69e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg19230755 chr7:65878503 NA -0.41 -5.75 -0.3 2e-8 Aortic root size; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.96 0.51 4.51e-24 Menopause (age at onset); LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg14893161 chr1:205819251 PM20D1 0.58 10.01 0.48 8.11e-21 Menarche (age at onset); LUSC cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -11.9 -0.55 1.89e-27 Mean corpuscular volume; LUSC cis rs11864453 0.826 rs12325142 chr16:72138112 G/T cg16558253 chr16:72132732 DHX38 -0.41 -6.32 -0.33 8.5e-10 Fibrinogen levels; LUSC cis rs2932538 0.922 rs12143068 chr1:113138110 A/G cg22162597 chr1:113214053 CAPZA1 0.7 10.1 0.48 4.1e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs10504073 0.647 rs4493918 chr8:50015937 C/G cg00325661 chr8:49890786 NA 0.62 10.04 0.48 6.47e-21 Blood metabolite ratios; LUSC trans rs2243480 0.908 rs55876148 chr7:65379800 G/A cg10756647 chr7:56101905 PSPH 0.88 8.43 0.42 1.02e-15 Diabetic kidney disease; LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg18404041 chr3:52824283 ITIH1 -0.63 -11.65 -0.54 1.45e-26 Bipolar disorder; LUSC cis rs908922 0.676 rs477621 chr1:152486252 T/C cg20991723 chr1:152506922 NA 0.49 8.97 0.44 2.19e-17 Hair morphology; LUSC cis rs6733011 0.628 rs4851163 chr2:99466664 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.71 -0.34 8.42e-11 Bipolar disorder; LUSC cis rs17155006 0.655 rs426812 chr7:107728512 T/C cg05962710 chr7:107745446 LAMB4 -0.33 -5.83 -0.3 1.31e-8 Pneumococcal bacteremia; LUSC trans rs11098499 0.863 rs3775847 chr4:120447642 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.55 0.34 2.17e-10 Corneal astigmatism; LUSC cis rs11190604 1.000 rs10883496 chr10:102221931 T/C cg16342193 chr10:102329863 NA -0.35 -6.39 -0.33 5.63e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs666930 0.519 rs662602 chr1:120266903 C/G cg19096424 chr1:120255104 PHGDH 0.59 8.28 0.41 3.02e-15 Breast cancer; LUSC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg18190219 chr22:46762943 CELSR1 -0.55 -6.02 -0.31 4.66e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs61931739 0.500 rs10772154 chr12:34373271 A/C cg26384229 chr12:38710491 ALG10B 0.77 13.05 0.58 1e-31 Morning vs. evening chronotype; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 14.01 0.61 2.15e-35 Platelet count; LUSC cis rs72781680 0.848 rs56218741 chr2:23977377 A/C cg20701182 chr2:24300061 SF3B14 0.57 6.02 0.31 4.55e-9 Lymphocyte counts; LUSC cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg21535247 chr6:8435926 SLC35B3 0.58 9.01 0.44 1.57e-17 Motion sickness; LUSC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs1185460 0.967 rs1784302 chr11:118940957 C/G cg23280166 chr11:118938394 VPS11 0.48 7.57 0.38 3.62e-13 Coronary artery disease; LUSC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg09085632 chr11:111637200 PPP2R1B -1.06 -17.67 -0.7 8.51e-50 Primary sclerosing cholangitis; LUSC cis rs17253792 0.822 rs75936910 chr14:56149351 T/C cg01858014 chr14:56050164 KTN1 -0.81 -6.96 -0.36 1.84e-11 Putamen volume; LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.06 0.31 3.77e-9 Menopause (age at onset); LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg24503407 chr1:205819492 PM20D1 1.01 23.16 0.79 1.86e-71 Menarche (age at onset); LUSC trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg03929089 chr4:120376271 NA 0.81 11.34 0.53 2e-25 Coronary artery disease; LUSC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 5.86 0.31 1.13e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg00220769 chr6:153305382 FBXO5 -0.43 -5.94 -0.31 7.04e-9 Neuroticism; LUSC cis rs9807989 0.507 rs6749014 chr2:103006448 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.29e-12 Asthma; LUSC cis rs1728785 0.901 rs3087783 chr16:68599668 C/T cg02972257 chr16:68554789 NA -0.52 -6.48 -0.33 3.26e-10 Ulcerative colitis; LUSC cis rs2279817 1.000 rs2279815 chr1:18022066 G/T cg21791023 chr1:18019539 ARHGEF10L 0.48 6.7 0.34 8.91e-11 Neuroticism; LUSC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg02891314 chr5:179741120 GFPT2 -0.58 -9.12 -0.45 6.99e-18 Height; LUSC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs10740039 0.883 rs7093573 chr10:62394369 C/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1506636 0.927 rs11983604 chr7:123329754 T/G cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.83 0.3 1.3e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3812831 0.695 rs6560935 chr13:114945867 G/A cg08824895 chr13:115047677 UPF3A 0.55 8.53 0.42 5.28e-16 Schizophrenia; LUSC cis rs631288 0.793 rs11239952 chr1:146715204 A/G cg25205988 chr1:146714368 CHD1L 1.08 7.41 0.38 1.02e-12 PR interval in Tripanosoma cruzi seropositivity; LUSC cis rs6121246 0.909 rs6060929 chr20:30345914 C/T cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.6 8.66 0.43 2.06e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg02503808 chr4:7069936 GRPEL1 1.04 14.8 0.63 1.77e-38 Monocyte percentage of white cells; LUSC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg05729581 chr11:3078854 CARS -0.54 -8.34 -0.42 1.97e-15 Longevity; LUSC cis rs1577917 0.958 rs4707223 chr6:86509802 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.72 -0.35 7.72e-11 Response to antipsychotic treatment; LUSC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg08677398 chr8:58056175 NA 0.5 5.85 0.3 1.17e-8 Developmental language disorder (linguistic errors); LUSC cis rs1185460 0.967 rs11217133 chr11:118928249 G/A cg23280166 chr11:118938394 VPS11 0.44 6.39 0.33 5.73e-10 Coronary artery disease; LUSC cis rs9660992 0.789 rs1768584 chr1:205240145 A/G cg21545522 chr1:205238299 TMCC2 0.5 9.64 0.47 1.48e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.11 -0.48 3.79e-21 Electroencephalogram traits; LUSC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.1 0.32 2.86e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs708547 0.874 rs1713984 chr4:57886493 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.67 8.58 0.43 3.53e-16 Response to bleomycin (chromatid breaks); LUSC cis rs67311347 0.577 rs1880763 chr3:40283255 C/T cg09455208 chr3:40491958 NA -0.47 -8.91 -0.44 3.28e-17 Renal cell carcinoma; LUSC cis rs6815814 0.861 rs7658651 chr4:38786002 A/C cg06935464 chr4:38784597 TLR10 0.45 5.81 0.3 1.42e-8 Breast cancer; LUSC cis rs4474465 1.000 rs10899513 chr11:78172353 T/C cg27205649 chr11:78285834 NARS2 -0.49 -5.79 -0.3 1.6e-8 Alzheimer's disease (survival time); LUSC cis rs7166081 0.738 rs28399271 chr15:67710011 G/A cg27219399 chr15:67835830 MAP2K5 0.37 5.95 0.31 6.81e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs7647973 0.626 rs7649428 chr3:49868876 A/T cg13072238 chr3:49761600 GMPPB 0.68 8.75 0.43 1.04e-16 Menarche (age at onset); LUSC cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.71e-9 Body mass index; LUSC cis rs4654899 0.965 rs4654898 chr1:21376383 T/C cg01072550 chr1:21505969 NA -0.53 -8.04 -0.4 1.55e-14 Superior frontal gyrus grey matter volume; LUSC cis rs12586317 0.620 rs10145433 chr14:35583333 G/A cg16230307 chr14:35515116 FAM177A1 0.77 10.07 0.48 5.28e-21 Psoriasis; LUSC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg05313129 chr8:58192883 C8orf71 -0.51 -6.64 -0.34 1.26e-10 Developmental language disorder (linguistic errors); LUSC cis rs1256061 0.654 rs1256031 chr14:64746179 C/T cg21174375 chr14:64681225 SYNE2 0.34 6.27 0.32 1.09e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs710216 0.752 rs841845 chr1:43404713 C/T cg03128534 chr1:43423976 SLC2A1 -0.46 -5.92 -0.31 8.03e-9 Red cell distribution width; LUSC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg23649088 chr2:200775458 C2orf69 0.55 7.42 0.38 9.66e-13 Schizophrenia; LUSC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 7.27 0.37 2.54e-12 Hip circumference adjusted for BMI; LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg27535305 chr1:53392650 SCP2 -0.48 -9.47 -0.46 5.31e-19 Monocyte count; LUSC trans rs3932549 1 rs3932549 chr9:97073588 A/C cg05679027 chr9:99775184 HIATL2 0.43 6.0 0.31 5.25e-9 Body mass index; LUSC cis rs12579753 1.000 rs10862374 chr12:82250809 G/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.86 -0.31 1.08e-8 Resting heart rate; LUSC cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg23711669 chr6:146136114 FBXO30 -0.83 -14.84 -0.63 1.25e-38 Lobe attachment (rater-scored or self-reported); LUSC trans rs979233 0.502 rs276259 chr5:42066323 C/T cg07010552 chr17:7358735 CHRNB1 -0.41 -6.02 -0.31 4.72e-9 Systemic lupus erythematosus; LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg01171360 chr6:293285 DUSP22 0.48 7.3 0.37 2.17e-12 Menopause (age at onset); LUSC trans rs7824557 0.815 rs2736372 chr8:11106041 T/C cg06636001 chr8:8085503 FLJ10661 -0.54 -8.32 -0.41 2.27e-15 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg07362569 chr17:61921086 SMARCD2 0.39 7.75 0.39 1.11e-13 Prudent dietary pattern; LUSC cis rs722599 0.683 rs10139016 chr14:75274288 T/C cg08847533 chr14:75593920 NEK9 0.45 6.33 0.33 7.74e-10 IgG glycosylation; LUSC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg10057126 chr4:77819792 ANKRD56 0.53 7.88 0.4 4.75e-14 Emphysema distribution in smoking; LUSC cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg00071950 chr4:10020882 SLC2A9 0.51 8.7 0.43 1.49e-16 Bone mineral density; LUSC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg00310523 chr12:86230176 RASSF9 0.44 7.75 0.39 1.12e-13 Major depressive disorder; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg18538332 chr22:24372958 LOC391322 -0.47 -8.25 -0.41 3.64e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1448094 0.842 rs12809288 chr12:86455427 C/T cg00310523 chr12:86230176 RASSF9 -0.36 -6.5 -0.33 2.98e-10 Major depressive disorder; LUSC cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.96e-12 Motion sickness; LUSC cis rs477692 0.870 rs512655 chr10:131424547 T/A cg11019008 chr10:131425282 MGMT 0.41 6.28 0.32 1.08e-9 Response to temozolomide; LUSC cis rs35146811 0.735 rs1727133 chr7:99812870 C/T cg22906224 chr7:99728672 NA -0.47 -6.52 -0.34 2.56e-10 Coronary artery disease; LUSC cis rs4953318 0.619 rs13406773 chr2:46362868 T/C cg12428440 chr2:46370979 PRKCE 0.46 7.74 0.39 1.18e-13 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg06873352 chr17:61820015 STRADA 0.57 8.78 0.43 8.9e-17 Height; LUSC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg23625390 chr15:77176239 SCAPER 0.46 7.05 0.36 1.05e-11 Blood metabolite levels; LUSC cis rs10822145 1 rs10822145 chr10:64934548 C/T cg01631684 chr10:65280961 REEP3 -0.4 -6.27 -0.32 1.1e-9 Triglycerides; LUSC cis rs12458462 0.859 rs35493271 chr18:77448793 G/T cg20476159 chr18:77451067 CTDP1 -0.31 -5.76 -0.3 1.95e-8 Monocyte count; LUSC cis rs427941 0.703 rs201453 chr7:101739788 T/C cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC trans rs617791 0.569 rs11227370 chr11:65747693 C/T cg17712092 chr4:129076599 LARP1B -0.73 -10.31 -0.49 7.87e-22 Breast cancer; LUSC trans rs10435719 0.902 rs7014580 chr8:11803262 C/G cg15556689 chr8:8085844 FLJ10661 0.58 8.79 0.43 7.75e-17 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1371867 0.817 rs1660314 chr8:101332953 C/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.91 -0.51 6.33e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs35110281 0.713 rs6518310 chr21:45098670 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.5 0.46 4.24e-19 Mean corpuscular volume; LUSC cis rs10905065 0.735 rs10795347 chr10:5742077 C/G cg11519256 chr10:5708881 ASB13 -0.45 -6.56 -0.34 2.07e-10 Menopause (age at onset); LUSC cis rs1983170 0.808 rs10874788 chr1:92017941 C/T cg25838465 chr1:92012736 NA 0.41 5.8 0.3 1.57e-8 Eosinophil percentage of white cells; LUSC cis rs612683 0.694 rs6688166 chr1:101000717 G/C cg09408571 chr1:101003634 GPR88 0.32 5.95 0.31 6.87e-9 Breast cancer; LUSC cis rs10979 0.557 rs9376767 chr6:143909380 G/A cg25407410 chr6:143891975 LOC285740 -0.65 -8.11 -0.41 9.93e-15 Hypospadias; LUSC cis rs7584330 0.737 rs1497127 chr2:238369282 A/G cg14458575 chr2:238380390 NA 0.61 10.83 0.51 1.22e-23 Prostate cancer; LUSC cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg03146154 chr1:46216737 IPP 0.56 8.36 0.42 1.75e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs372883 0.506 rs2832300 chr21:30749315 A/G cg24692254 chr21:30365293 RNF160 0.68 10.73 0.51 2.77e-23 Pancreatic cancer; LUSC cis rs1559088 0.948 rs10408093 chr19:33597816 T/C cg17764715 chr19:33622953 WDR88 0.6 8.29 0.41 2.72e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg04944784 chr2:26401820 FAM59B 0.78 11.34 0.53 1.94e-25 Gut microbiome composition (summer); LUSC cis rs9815354 0.680 rs61646756 chr3:42029352 A/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs977987 0.806 rs72787160 chr16:75445162 G/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.63 -0.34 1.3100000000000001e-10 Dupuytren's disease; LUSC cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg22467129 chr15:76604101 ETFA -0.42 -6.74 -0.35 7.16e-11 Blood metabolite levels; LUSC cis rs62400317 0.859 rs62438864 chr6:45041787 G/A cg20913747 chr6:44695427 NA -0.46 -7.43 -0.38 9.41e-13 Total body bone mineral density; LUSC trans rs12579753 1.000 rs7966755 chr12:82221604 A/G cg07923666 chr12:49932857 KCNH3 -0.52 -6.4 -0.33 5.15e-10 Resting heart rate; LUSC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg00074818 chr8:8560427 CLDN23 -0.51 -8.75 -0.43 1.07e-16 Obesity-related traits; LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg09877947 chr5:131593287 PDLIM4 0.51 7.88 0.4 4.63e-14 Acylcarnitine levels; LUSC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg23719950 chr11:63933701 MACROD1 0.41 6.36 0.33 6.75e-10 Platelet count; LUSC cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg06784218 chr1:46089804 CCDC17 0.48 9.33 0.45 1.47e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.96 0.44 2.3e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs7587476 0.784 rs34112702 chr2:215696002 A/G cg04004882 chr2:215674386 BARD1 0.49 6.38 0.33 5.93e-10 Neuroblastoma; LUSC cis rs868036 0.681 rs4776375 chr15:68085555 G/A cg05925327 chr15:68127851 NA -0.41 -6.62 -0.34 1.46e-10 Restless legs syndrome; LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.5 7.67 0.39 1.86e-13 Parkinson's disease; LUSC cis rs694739 1.000 rs499425 chr11:64105929 A/G cg23796481 chr11:64053134 BAD;GPR137 -0.6 -9.9 -0.48 2e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg17385448 chr1:15911702 AGMAT 0.37 6.15 0.32 2.19e-9 Systolic blood pressure; LUSC cis rs1023500 0.551 rs4822076 chr22:42364057 C/T cg04733989 chr22:42467013 NAGA 0.49 6.66 0.34 1.12e-10 Schizophrenia; LUSC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg09455208 chr3:40491958 NA 0.58 9.77 0.47 5.57e-20 Renal cell carcinoma; LUSC cis rs1448094 0.935 rs11117108 chr12:86322310 T/A cg00310523 chr12:86230176 RASSF9 0.4 7.33 0.37 1.8e-12 Major depressive disorder; LUSC cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg08999081 chr20:33150536 PIGU -0.53 -10.53 -0.5 1.36e-22 Glomerular filtration rate (creatinine); LUSC cis rs713587 0.713 rs11682135 chr2:25205377 G/A cg15423357 chr2:25149977 NA -0.37 -7.35 -0.37 1.55e-12 Body mass index in non-asthmatics; LUSC cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg00677455 chr12:58241039 CTDSP2 0.59 8.39 0.42 1.35e-15 Multiple sclerosis; LUSC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs7818345 0.967 rs4617172 chr8:19273362 G/A cg11303988 chr8:19266685 CSGALNACT1 0.4 7.63 0.39 2.52e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs10782582 0.569 rs4549990 chr1:76125075 A/G cg22875332 chr1:76189707 ACADM -0.42 -6.24 -0.32 1.35e-9 Daytime sleep phenotypes; LUSC cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg00631329 chr6:26305371 NA -0.45 -8.86 -0.44 4.68e-17 Educational attainment; LUSC cis rs12474201 0.894 rs34401107 chr2:46972768 A/C cg06386533 chr2:46925753 SOCS5 0.72 10.74 0.51 2.66e-23 Height; LUSC trans rs7939886 0.920 rs11227158 chr11:55843795 A/G cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg26384229 chr12:38710491 ALG10B 0.92 17.56 0.69 2.35e-49 Heart rate; LUSC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg05340658 chr4:99064831 C4orf37 0.68 11.57 0.53 2.84e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.863 rs1480939 chr4:120456927 T/C cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs11122272 0.735 rs2572254 chr1:231512593 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.88 0.48 2.27e-20 Hemoglobin concentration; LUSC cis rs1550582 0.548 rs7828645 chr8:135497385 A/G cg17885191 chr8:135476712 NA -0.91 -14.09 -0.61 1.07e-35 Educational attainment; LUSC cis rs10779751 1.000 rs4845858 chr1:11304720 C/T cg08854313 chr1:11322531 MTOR 0.9 16.01 0.66 3.38e-43 Body mass index; LUSC cis rs10779751 0.690 rs2791659 chr1:11126569 C/A cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs7264396 0.790 rs2207889 chr20:34224898 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -10.02 -0.48 7.54e-21 Total cholesterol levels; LUSC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg07424592 chr7:64974309 NA 0.69 6.18 0.32 1.88e-9 Diabetic kidney disease; LUSC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg03354898 chr7:1950403 MAD1L1 -0.35 -6.8 -0.35 4.76e-11 Schizophrenia; LUSC cis rs6089829 0.962 rs6011544 chr20:61658782 T/C cg08045932 chr20:61659980 NA 0.55 9.23 0.45 3.17e-18 Prostate cancer (SNP x SNP interaction); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04198698 chr15:62515913 NA 0.34 6.43 0.33 4.48e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs12681287 0.547 rs35871312 chr8:87543219 T/C cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs965469 1.000 rs6037590 chr20:3374085 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -5.76 -0.3 1.93e-8 IFN-related cytopenia; LUSC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg10792982 chr14:105748885 BRF1 0.48 8.77 0.43 9.27e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs13082711 0.595 rs17317435 chr3:27339326 A/G cg02860705 chr3:27208620 NA 0.75 11.94 0.55 1.31e-27 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs11992162 0.573 rs13275808 chr8:11782815 T/C cg14343924 chr8:8086146 FLJ10661 -0.45 -6.23 -0.32 1.43e-9 Monocyte count; LUSC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg14061069 chr19:46274453 DMPK 0.68 14.06 0.61 1.34e-35 Coronary artery disease; LUSC cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg18404041 chr3:52824283 ITIH1 0.39 6.73 0.35 7.52e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs11209002 0.524 rs2815386 chr1:67541996 A/G cg02640540 chr1:67518911 SLC35D1 0.62 8.53 0.42 5.27e-16 Crohn's disease; LUSC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg24060327 chr5:131705240 SLC22A5 -0.47 -8.21 -0.41 4.91e-15 Blood metabolite levels; LUSC cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg09034736 chr1:150693464 HORMAD1 -0.43 -5.84 -0.3 1.24e-8 Urate levels; LUSC trans rs4927850 1.000 rs7627706 chr3:195753353 A/C cg21051086 chr3:73046214 PPP4R2 -0.52 -7.96 -0.4 2.63e-14 Pancreatic cancer; LUSC cis rs10197940 0.624 rs13393122 chr2:152413315 A/G cg06191203 chr2:152266755 RIF1 -0.55 -7.29 -0.37 2.21e-12 Lung cancer; LUSC trans rs11782517 0.883 rs13258235 chr8:10106503 A/G cg15556689 chr8:8085844 FLJ10661 -0.52 -6.05 -0.31 3.99e-9 Nose size; LUSC cis rs3796619 1.000 rs4045481 chr4:1090625 C/T cg27284194 chr4:1044797 NA 0.45 7.34 0.37 1.67e-12 Recombination rate (males); LUSC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg04511125 chr2:88470314 THNSL2 0.96 9.14 0.45 6.02e-18 Plasma clusterin levels; LUSC cis rs9650315 0.530 rs7830138 chr8:57084125 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.54 8.36 0.42 1.72e-15 Height; LUSC trans rs1994135 0.565 rs11052767 chr12:33731194 A/G cg13010199 chr12:38710504 ALG10B 0.51 7.0 0.36 1.4e-11 Resting heart rate; LUSC cis rs4363385 0.747 rs6665575 chr1:152960506 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.49 -0.38 6.08e-13 Inflammatory skin disease; LUSC cis rs7937682 0.924 rs7938360 chr11:111539875 A/G cg19812747 chr11:111475976 SIK2 -0.49 -6.99 -0.36 1.51e-11 Primary sclerosing cholangitis; LUSC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.35 -0.42 1.79e-15 Height; LUSC cis rs10892173 0.765 rs7125694 chr11:117670657 C/T cg21640587 chr11:117668038 DSCAML1 0.35 5.72 0.3 2.35e-8 Myopia; LUSC cis rs11716531 0.512 rs7612312 chr3:27230230 C/A cg02860705 chr3:27208620 NA 0.43 7.82 0.39 6.87e-14 Diastolic blood pressure; LUSC cis rs10504073 0.584 rs62507178 chr8:49938572 A/C cg00325661 chr8:49890786 NA 0.71 11.19 0.52 6.77e-25 Blood metabolite ratios; LUSC cis rs3096299 0.606 rs2965960 chr16:89541795 G/A cg00750074 chr16:89608354 SPG7 -0.46 -7.0 -0.36 1.41e-11 Multiple myeloma (IgH translocation); LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg27094323 chr7:1216898 NA -0.42 -7.08 -0.36 8.7e-12 Longevity;Endometriosis; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg01628140 chr12:102590990 C12orf48;PMCH -0.4 -6.15 -0.32 2.24e-9 Calcium levels; LUSC cis rs1691799 0.899 rs903590 chr12:66745777 C/G cg16791601 chr12:66731901 HELB -0.74 -12.51 -0.56 9.93e-30 White blood cell count (basophil); LUSC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg21724239 chr8:58056113 NA 0.55 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.24 0.32 1.29e-9 Age-related macular degeneration (geographic atrophy); LUSC trans rs561341 1.000 rs527256 chr17:30321293 C/G cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC trans rs6089829 0.962 rs2277768 chr20:61666823 T/C cg23505145 chr19:12996616 KLF1 0.64 10.87 0.51 8.87e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg18252515 chr7:66147081 NA -0.57 -7.85 -0.39 5.71e-14 Corneal structure; LUSC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.26 0.56 8.73e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg02079420 chr8:82753780 SNX16 0.42 7.19 0.37 4.24e-12 Diastolic blood pressure; LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg11843238 chr5:131593191 PDLIM4 0.5 9.01 0.44 1.63e-17 Acylcarnitine levels; LUSC cis rs11122272 0.766 rs2024879 chr1:231528638 A/G cg06096015 chr1:231504339 EGLN1 0.57 10.12 0.48 3.69e-21 Hemoglobin concentration; LUSC cis rs1790761 0.692 rs10444362 chr11:67333090 G/A cg24690094 chr11:67383802 NA 0.42 8.24 0.41 4.1e-15 Mean corpuscular volume; LUSC cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -6.26 -0.32 1.16e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg07167872 chr1:205819463 PM20D1 0.84 15.52 0.65 2.81e-41 Menarche (age at onset); LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg22903657 chr4:1355424 KIAA1530 -0.35 -5.78 -0.3 1.68e-8 Obesity-related traits; LUSC cis rs12776158 1.000 rs34618077 chr10:71216134 T/C cg12610070 chr10:71211762 TSPAN15 -0.46 -6.05 -0.31 3.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9611565 0.918 rs4820438 chr22:41767135 C/T cg06634786 chr22:41940651 POLR3H -0.46 -5.9 -0.31 8.9e-9 Vitiligo; LUSC cis rs533581 0.866 rs2968474 chr16:88970566 A/G cg16701003 chr16:89028210 CBFA2T3 -0.32 -5.78 -0.3 1.7e-8 Social autistic-like traits; LUSC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7647973 1.000 rs940045 chr3:49449638 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.89 0.35 2.77e-11 Menarche (age at onset); LUSC cis rs1790761 0.692 rs1269981 chr11:67334959 G/A cg00290607 chr11:67383545 NA 0.36 6.7 0.34 9.12e-11 Mean corpuscular volume; LUSC cis rs911119 1.000 rs911119 chr20:23612737 C/T cg16589663 chr20:23618590 CST3 -0.53 -6.4 -0.33 5.13e-10 Chronic kidney disease; LUSC cis rs4851254 0.920 rs4850920 chr2:100757308 C/A cg07810366 chr2:100720526 AFF3 -0.36 -5.66 -0.3 3.19e-8 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.44 -5.97 -0.31 5.99e-9 Renal function-related traits (BUN); LUSC cis rs7917772 0.582 rs10786684 chr10:104323028 A/C cg22532475 chr10:104410764 TRIM8 0.26 6.27 0.32 1.15e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34779708 0.702 rs4244995 chr10:35547175 A/G cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13401104 0.796 rs12464503 chr2:237113007 C/T cg19324714 chr2:237145437 ASB18 0.43 5.79 0.3 1.67e-8 Educational attainment; LUSC cis rs708547 0.874 rs1718837 chr4:57871203 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.69 9.61 0.47 1.89e-19 Response to bleomycin (chromatid breaks); LUSC cis rs11971779 0.584 rs17613864 chr7:139095587 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg18240062 chr17:79603768 NPLOC4 0.58 10.09 0.48 4.35e-21 Eye color traits; LUSC cis rs67311347 0.955 rs2123999 chr3:40378738 C/T cg09455208 chr3:40491958 NA 0.52 9.54 0.46 3.11e-19 Renal cell carcinoma; LUSC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg07414643 chr4:187882934 NA 0.57 10.8 0.51 1.61e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs12586317 0.620 rs17091786 chr14:35565856 A/T cg05294307 chr14:35346193 BAZ1A -0.56 -6.62 -0.34 1.39e-10 Psoriasis; LUSC cis rs1395 0.778 rs2580761 chr2:27426362 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.27 0.37 2.64e-12 Blood metabolite levels; LUSC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg23711669 chr6:146136114 FBXO30 0.82 14.02 0.61 2e-35 Lobe attachment (rater-scored or self-reported); LUSC trans rs7615952 0.866 rs11922276 chr3:125631326 G/T cg07211511 chr3:129823064 LOC729375 -1.18 -17.99 -0.7 4.68e-51 Blood pressure (smoking interaction); LUSC cis rs950776 0.752 rs62010327 chr15:78892784 G/A cg06917634 chr15:78832804 PSMA4 0.74 12.35 0.56 4.13e-29 Sudden cardiac arrest; LUSC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.44 8.21 0.41 5e-15 Breast cancer; LUSC cis rs6076065 0.723 rs761726 chr20:23401481 G/C cg11657817 chr20:23433608 CST11 0.41 7.38 0.37 1.29e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg27539214 chr16:67997921 SLC12A4 -0.58 -7.67 -0.39 1.9e-13 HDL cholesterol;Metabolic syndrome; LUSC trans rs2727020 0.553 rs61904166 chr11:49581461 T/C cg03929089 chr4:120376271 NA -0.95 -16.18 -0.66 6.84e-44 Coronary artery disease; LUSC cis rs7786808 0.586 rs7794256 chr7:158206214 T/G cg01191920 chr7:158217561 PTPRN2 0.42 8.39 0.42 1.41e-15 Obesity-related traits; LUSC cis rs11098499 0.754 rs10518300 chr4:120249499 G/T cg09307838 chr4:120376055 NA -0.66 -9.63 -0.47 1.61e-19 Corneal astigmatism; LUSC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.62 8.02 0.4 1.82e-14 Schizophrenia; LUSC cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg14844989 chr11:31128820 NA -0.37 -5.86 -0.31 1.13e-8 Red blood cell count; LUSC trans rs877282 1.000 rs2004479 chr10:770854 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.76 -0.35 5.99e-11 Uric acid levels; LUSC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg16447950 chr5:562315 NA -0.57 -6.95 -0.36 1.97e-11 Lung disease severity in cystic fibrosis; LUSC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.43 -6.66 -0.34 1.13e-10 Alzheimer's disease (late onset); LUSC cis rs6964587 0.692 rs4729021 chr7:91758422 C/A cg17063962 chr7:91808500 NA 0.58 9.73 0.47 7.14e-20 Breast cancer; LUSC cis rs859767 0.741 rs883964 chr2:135436200 G/C cg12500956 chr2:135428796 TMEM163 -0.29 -6.47 -0.33 3.55e-10 Neuroticism; LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18099408 chr3:52552593 STAB1 -0.4 -6.79 -0.35 5.01e-11 Bipolar disorder; LUSC cis rs9341808 0.754 rs1015158 chr6:80945745 C/T cg08355045 chr6:80787529 NA 0.56 9.62 0.47 1.7e-19 Sitting height ratio; LUSC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7937682 0.562 rs527847 chr11:111369132 A/C cg09085632 chr11:111637200 PPP2R1B 0.52 7.43 0.38 9.4e-13 Primary sclerosing cholangitis; LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 16.51 0.67 3.47e-45 Gut microbiome composition (summer); LUSC cis rs7927592 0.913 rs7106339 chr11:68240241 C/T cg20283391 chr11:68216788 NA -0.61 -8.53 -0.42 5e-16 Total body bone mineral density; LUSC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.78 0.51 1.84e-23 Hip circumference adjusted for BMI; LUSC cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg26647111 chr11:31128758 NA -0.42 -6.05 -0.31 3.81e-9 Red blood cell count; LUSC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg13114125 chr14:105738426 BRF1 -0.92 -15.57 -0.65 1.81e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg23791538 chr6:167370224 RNASET2 0.42 6.82 0.35 4.24e-11 Crohn's disease; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg12143784 chr7:64541923 NA -0.38 -6.02 -0.31 4.68e-9 Calcium levels; LUSC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.54 0.46 3.18e-19 Mean platelet volume; LUSC trans rs9944715 0.954 rs8098751 chr18:43850587 G/A cg01718231 chr17:29326311 RNF135 -0.5 -7.07 -0.36 9.02e-12 Red cell distribution width;Mean corpuscular volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15505349 chr1:246670199 SMYD3 0.51 6.9 0.35 2.63e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.74 0.51 2.64e-23 Bladder cancer; LUSC cis rs9902453 0.874 rs7213517 chr17:28401740 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.84 -0.51 1.16e-23 Coffee consumption (cups per day); LUSC cis rs1568889 0.838 rs1483858 chr11:28189639 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.66 0.57 2.87e-30 Bipolar disorder; LUSC cis rs5769765 0.908 rs7410318 chr22:50317049 T/C cg02269571 chr22:50332266 NA -0.64 -9.46 -0.46 5.77e-19 Schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06459454 chr8:146033798 ZNF517 -0.79 -6.5 -0.34 2.87e-10 Cognitive performance; LUSC cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg13798780 chr7:105162888 PUS7 0.53 5.96 0.31 6.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.78 -10.02 -0.48 7.58e-21 Gut microbiome composition (summer); LUSC cis rs5769765 0.542 rs1033666 chr22:50252783 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.63 6.79 0.35 5e-11 Schizophrenia; LUSC cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.43 -6.62 -0.34 1.41e-10 Intelligence (multi-trait analysis); LUSC cis rs11608355 0.515 rs1045582 chr12:109915727 G/T cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg10802521 chr3:52805072 NEK4 -0.54 -8.71 -0.43 1.43e-16 Bipolar disorder; LUSC cis rs2857891 0.817 rs2857903 chr11:6979378 G/A cg14883916 chr11:6947541 ZNF215 0.45 5.79 0.3 1.59e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs17401966 0.540 rs10864452 chr1:10395683 G/T cg19773385 chr1:10388646 KIF1B -0.39 -6.82 -0.35 4.2e-11 Hepatocellular carcinoma; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs6542838 0.641 rs12467189 chr2:99495820 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.39 -0.33 5.73e-10 Fear of minor pain; LUSC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs2839186 0.721 rs13051200 chr21:47701693 A/T cg13126279 chr21:47581558 C21orf56 -0.42 -6.17 -0.32 1.93e-9 Testicular germ cell tumor; LUSC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg21573476 chr21:45109991 RRP1B -0.42 -6.82 -0.35 4.16e-11 Mean corpuscular volume; LUSC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg15145296 chr3:125709740 NA -0.57 -6.36 -0.33 6.67e-10 Blood pressure (smoking interaction); LUSC trans rs11098499 0.954 rs56270433 chr4:120406030 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 4.01e-10 Corneal astigmatism; LUSC cis rs708547 0.676 rs11133470 chr4:57864926 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.56 8.38 0.42 1.49e-15 Response to bleomycin (chromatid breaks); LUSC cis rs4919694 1.000 rs12246689 chr10:104817031 C/T cg04362960 chr10:104952993 NT5C2 1.18 13.92 0.61 4.83e-35 Arsenic metabolism; LUSC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg24675056 chr1:15929824 NA 0.45 7.76 0.39 1.02e-13 Systolic blood pressure; LUSC cis rs1322512 0.713 rs1631244 chr6:152939865 C/T cg27316956 chr6:152958899 SYNE1 -0.35 -5.8 -0.3 1.58e-8 Tonometry; LUSC trans rs62458065 0.713 rs3801329 chr7:32496956 A/C cg00845942 chr12:64062724 DPY19L2 -0.55 -6.59 -0.34 1.74e-10 Metabolite levels (HVA/MHPG ratio); LUSC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg27170947 chr2:26402098 FAM59B -0.61 -9.13 -0.45 6.72e-18 Gut microbiome composition (summer); LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs7267979 1.000 rs6050562 chr20:25336186 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.8 -0.73 2.78e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg25019033 chr10:957182 NA -0.53 -6.74 -0.35 6.97e-11 Eosinophil percentage of granulocytes; LUSC cis rs6120849 0.707 rs3746444 chr20:33578251 A/G cg24642439 chr20:33292090 TP53INP2 0.62 6.81 0.35 4.68e-11 Protein C levels; LUSC cis rs6494488 0.500 rs72742966 chr15:64919179 G/A cg08069370 chr15:64387884 SNX1 -0.65 -5.78 -0.3 1.75e-8 Coronary artery disease; LUSC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.03 0.55 6.17e-28 Cognitive test performance; LUSC cis rs6714710 0.603 rs55776387 chr2:98405034 T/C cg26665480 chr2:98280029 ACTR1B 0.6 8.75 0.43 1.06e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs478304 0.903 rs546202 chr11:65510024 C/T cg08755490 chr11:65554678 OVOL1 -0.4 -5.76 -0.3 1.9e-8 Acne (severe); LUSC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg16447950 chr5:562315 NA -0.51 -6.51 -0.34 2.71e-10 Obesity-related traits; LUSC cis rs2486288 0.656 rs11632920 chr15:45551264 C/T cg09092052 chr15:45571596 NA 0.46 6.56 0.34 2.1e-10 Glomerular filtration rate; LUSC cis rs80282103 0.764 rs12247779 chr10:1107957 T/G cg18964960 chr10:1102726 WDR37 0.69 6.33 0.33 8e-10 Glomerular filtration rate (creatinine); LUSC cis rs9326248 0.539 rs660443 chr11:116760693 T/C cg01368799 chr11:117014884 PAFAH1B2 0.58 8.71 0.43 1.48e-16 Blood protein levels; LUSC cis rs7223966 1.000 rs11658175 chr17:61923838 G/A cg05941027 chr17:61774174 LIMD2 0.22 5.8 0.3 1.56e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg02423579 chr7:2872169 GNA12 -0.43 -6.26 -0.32 1.21e-9 Height; LUSC trans rs637571 0.522 rs12792888 chr11:65761446 C/T cg17712092 chr4:129076599 LARP1B 0.81 12.23 0.56 1.17e-28 Eosinophil percentage of white cells; LUSC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg01181863 chr3:195395398 SDHAP2 0.6 8.1 0.41 1.02e-14 Pancreatic cancer; LUSC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 5.93 0.31 7.71e-9 Intelligence (multi-trait analysis); LUSC cis rs113352275 1 rs113352275 chr15:78840567 C/T cg24631222 chr15:78858424 CHRNA5 0.87 11.71 0.54 9.44e-27 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg05855489 chr10:104503620 C10orf26 0.59 9.39 0.46 9.82e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg27165867 chr14:105738592 BRF1 -0.52 -7.54 -0.38 4.4e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg22963979 chr7:1858916 MAD1L1 -0.7 -11.43 -0.53 8.94e-26 Bipolar disorder and schizophrenia; LUSC cis rs9399135 0.967 rs9389254 chr6:135330709 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.12 0.45 7.4e-18 Red blood cell count; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.29 6.17 0.32 2e-9 Electroencephalogram traits; LUSC cis rs9326248 0.509 rs533556 chr11:116741572 A/C cg20608306 chr11:116969690 SIK3 0.36 6.75 0.35 6.56e-11 Blood protein levels; LUSC cis rs4478037 1.000 rs58864038 chr3:33161355 G/A cg19404215 chr3:33155277 CRTAP 0.96 9.76 0.47 5.72e-20 Major depressive disorder; LUSC cis rs908922 0.676 rs945789 chr1:152512705 C/A cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6121246 0.909 rs1994249 chr20:30287593 C/T cg13852791 chr20:30311386 BCL2L1 0.88 11.91 0.55 1.72e-27 Mean corpuscular hemoglobin; LUSC trans rs61931739 0.500 rs11053278 chr12:34555955 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs4843185 0.669 rs889502 chr16:85716832 A/G cg05245094 chr16:85669572 KIAA0182 0.43 6.2 0.32 1.64e-9 Platelet distribution width; LUSC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg06636001 chr8:8085503 FLJ10661 0.59 9.16 0.45 5.33e-18 Mood instability; LUSC cis rs9487051 0.768 rs1269172 chr6:109522080 G/C cg00509249 chr6:109615579 CCDC162 -0.33 -5.79 -0.3 1.66e-8 Reticulocyte fraction of red cells; LUSC cis rs17001868 0.568 rs9607699 chr22:40737036 G/A cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs7520050 0.778 rs2088102 chr1:46032974 T/C cg06784218 chr1:46089804 CCDC17 -0.3 -5.89 -0.31 9.63e-9 Red blood cell count;Reticulocyte count; LUSC trans rs2018683 0.707 rs10279870 chr7:28968935 A/G cg19402173 chr7:128379420 CALU -0.45 -6.87 -0.35 3.06e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg24562669 chr7:97807699 LMTK2 0.35 6.27 0.32 1.13e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2197308 0.606 rs2218397 chr12:38278307 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.76 -0.35 6.16e-11 Morning vs. evening chronotype; LUSC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg11663144 chr21:46675770 NA -0.42 -7.34 -0.37 1.59e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.35 0.42 1.88e-15 Hemoglobin concentration; LUSC cis rs791888 1.000 rs791888 chr10:89412575 G/T cg13926569 chr10:89418898 PAPSS2 -0.3 -5.7 -0.3 2.6e-8 Magnesium levels; LUSC cis rs2625529 0.526 rs10851850 chr15:72486509 A/G cg16672083 chr15:72433130 SENP8 0.47 7.72 0.39 1.34e-13 Red blood cell count; LUSC cis rs7615952 0.673 rs3811677 chr3:125648080 G/A cg02807482 chr3:125708958 NA -0.49 -5.73 -0.3 2.21e-8 Blood pressure (smoking interaction); LUSC cis rs765787 0.530 rs12323957 chr15:45490773 C/T cg25801113 chr15:45476975 SHF -0.33 -6.44 -0.33 4.06e-10 Uric acid levels; LUSC cis rs6088813 1.000 rs2425066 chr20:33927006 A/C cg14752227 chr20:34000481 UQCC 0.36 5.65 0.3 3.4e-8 Height; LUSC cis rs12681287 0.640 rs13264364 chr8:87466385 G/T cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs12210905 0.925 rs12192502 chr6:26995720 A/C cg23155468 chr6:27110703 HIST1H2BK 0.6 5.74 0.3 2.1e-8 Hip circumference adjusted for BMI; LUSC cis rs983392 0.679 rs4938932 chr11:60033448 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.08 0.32 3.31e-9 Alzheimer's disease (late onset); LUSC cis rs9814567 0.806 rs13076825 chr3:134317239 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.77 12.6 0.57 4.77e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs988712 0.705 rs4923460 chr11:27656789 A/C cg10635145 chr11:27742435 BDNF 0.45 6.07 0.32 3.5e-9 Obesity; LUSC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.76 -0.35 6.22e-11 Lung cancer; LUSC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC cis rs308403 0.568 rs13135778 chr4:123664446 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.79 10.18 0.49 2.16e-21 Blood protein levels; LUSC cis rs4285028 0.731 rs2877561 chr3:121712051 A/C cg11130432 chr3:121712080 ILDR1 0.71 11.85 0.54 2.72e-27 Multiple sclerosis; LUSC cis rs7769051 0.522 rs57176306 chr6:133142168 C/T cg22852734 chr6:133119734 C6orf192 1.28 10.95 0.51 4.58e-24 Type 2 diabetes nephropathy; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.72 0.43 1.34e-16 Prudent dietary pattern; LUSC cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs72949976 1.000 rs62186568 chr2:214033955 G/A cg08319019 chr2:214017104 IKZF2 -0.61 -9.37 -0.46 1.15e-18 Lung cancer;Squamous cell lung carcinoma; LUSC trans rs3960554 0.569 rs11973658 chr7:75882026 A/C cg19862616 chr7:65841803 NCRNA00174 0.65 8.14 0.41 7.96e-15 Eotaxin levels; LUSC cis rs988712 0.622 rs4922793 chr11:27729505 A/G cg10635145 chr11:27742435 BDNF -0.48 -6.46 -0.33 3.66e-10 Obesity; LUSC trans rs1864729 0.892 rs1821134 chr8:98266824 C/T cg08679828 chr8:102218111 ZNF706 0.79 7.12 0.36 6.56e-12 Estradiol plasma levels (breast cancer); LUSC cis rs12986413 1.000 rs12983458 chr19:2168612 A/G cg09261902 chr19:2140048 AP3D1 0.31 5.93 0.31 7.51e-9 Height; LUSC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08109568 chr15:31115862 NA -0.74 -11.03 -0.52 2.51e-24 Huntington's disease progression; LUSC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.32 -0.33 8.19e-10 Lung cancer; LUSC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 10.18 0.49 2.24e-21 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg05340658 chr4:99064831 C4orf37 -0.67 -11.16 -0.52 8.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1003719 0.788 rs2040341 chr21:38489753 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.24 0.52 4.29e-25 Eye color traits; LUSC cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg01849466 chr14:104193079 ZFYVE21 0.53 8.12 0.41 8.99e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs2708377 0.799 rs7296270 chr12:11311590 A/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs7216064 0.911 rs6504551 chr17:65903326 T/G cg12091567 chr17:66097778 LOC651250 -0.64 -9.14 -0.45 6.26e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs10892173 0.765 rs7125693 chr11:117670651 C/T cg21640587 chr11:117668038 DSCAML1 0.35 5.72 0.3 2.35e-8 Myopia; LUSC cis rs4363385 0.617 rs5010885 chr1:152973141 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.67 -0.3 3.09e-8 Inflammatory skin disease; LUSC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg05855489 chr10:104503620 C10orf26 0.59 9.5 0.46 4.35e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.53e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs3764021 0.933 rs10492165 chr12:9885961 A/G cg20894963 chr12:9885564 CLECL1 0.35 7.05 0.36 1.06e-11 Type 1 diabetes; LUSC cis rs2280018 0.526 rs2966128 chr16:15153389 G/T cg27102117 chr16:15229624 NA 0.49 7.55 0.38 4.18e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs10511400 0.867 rs6438569 chr3:119953272 C/T cg02809009 chr19:50354510 PTOV1 -0.69 -6.04 -0.31 4.15e-9 Economic and political preferences (feminism/equality); LUSC cis rs4629710 0.645 rs34601891 chr6:131551238 C/T cg12700074 chr6:131571435 AKAP7 -0.36 -5.96 -0.31 6.33e-9 Multiple myeloma (IgH translocation); LUSC cis rs2762353 0.603 rs9393670 chr6:25789061 A/G cg03517284 chr6:25882590 NA 0.35 6.14 0.32 2.35e-9 Blood metabolite levels; LUSC cis rs60843830 1.000 rs60843830 chr2:286756 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.64 9.39 0.46 9.47e-19 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg21573476 chr21:45109991 RRP1B -0.41 -6.69 -0.34 9.51e-11 Mean corpuscular volume; LUSC cis rs3806843 0.932 rs2563256 chr5:140141779 G/T cg26395211 chr5:140044315 WDR55 0.37 5.72 0.3 2.32e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg06637938 chr14:75390232 RPS6KL1 -0.43 -6.46 -0.33 3.73e-10 Neuroticism; LUSC cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs7945705 0.875 rs10769947 chr11:8758114 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.31 6.17 0.32 1.96e-9 Hemoglobin concentration; LUSC cis rs61931739 0.500 rs11836198 chr12:34552782 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.39 8.34 0.42 1.98e-15 Hemoglobin concentration; LUSC cis rs9494145 0.667 rs1331309 chr6:135406178 T/G cg22676075 chr6:135203613 NA 0.68 9.47 0.46 5.29e-19 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs9359856 0.510 rs78649003 chr6:90454644 A/C cg13799429 chr6:90582589 CASP8AP2 -0.91 -10.67 -0.5 4.44e-23 Bipolar disorder; LUSC cis rs16854884 0.584 rs34372603 chr3:143738249 T/C cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs7772486 0.774 rs2247571 chr6:146219533 T/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.17 -0.32 1.95e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs617219 0.927 rs949644 chr5:78442351 A/G cg24856658 chr5:78533917 JMY -0.3 -5.7 -0.3 2.69e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs7829975 0.573 rs7842359 chr8:8797078 T/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.94 -0.48 1.47e-20 Mood instability; LUSC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.43 6.42 0.33 4.69e-10 Systemic lupus erythematosus; LUSC cis rs897984 0.683 rs12447534 chr16:30804257 C/T cg00531865 chr16:30841666 NA 0.34 6.14 0.32 2.31e-9 Dementia with Lewy bodies; LUSC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg13206674 chr6:150067644 NUP43 0.59 9.6 0.47 1.94e-19 Lung cancer; LUSC trans rs9329221 1.000 rs9329221 chr8:10240202 G/T cg15556689 chr8:8085844 FLJ10661 0.53 8.04 0.4 1.57e-14 Neuroticism; LUSC cis rs1577917 0.740 rs2758843 chr6:86328431 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -9.44 -0.46 6.56e-19 Response to antipsychotic treatment; LUSC cis rs9653442 0.564 rs4851261 chr2:100786717 A/G cg22139774 chr2:100720529 AFF3 -0.41 -7.12 -0.36 6.51e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs868036 0.681 rs4548812 chr15:68060552 G/A cg08079166 chr15:68083412 MAP2K5 0.41 7.35 0.37 1.51e-12 Restless legs syndrome; LUSC cis rs7524258 0.868 rs11120885 chr1:7306755 C/G cg07173049 chr1:7289937 CAMTA1 0.32 6.71 0.34 8.32e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs11229555 0.645 rs12802960 chr11:58174775 T/C cg15696309 chr11:58395628 NA -0.63 -7.8 -0.39 8.25e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs12579753 0.917 rs11612874 chr12:82212649 A/C cg07923666 chr12:49932857 KCNH3 0.51 6.04 0.31 4.1e-9 Resting heart rate; LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.51 0.65 3.02e-41 Platelet count; LUSC cis rs73416724 1.000 rs70953686 chr6:43269516 G/A cg26312998 chr6:43337775 ZNF318 0.56 6.34 0.33 7.59e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.0 -0.31 5.24e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4903604 0.581 rs4903607 chr14:78038462 G/A cg18872420 chr14:78023429 SPTLC2 0.39 6.09 0.32 3.17e-9 Gut microbiome composition (winter); LUSC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs5758511 0.573 rs4501042 chr22:42245763 C/T cg03131358 chr22:42195972 CCDC134 -0.32 -5.73 -0.3 2.24e-8 Birth weight; LUSC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg04398451 chr17:18023971 MYO15A -0.56 -9.16 -0.45 5.29e-18 Total body bone mineral density; LUSC cis rs73198271 0.740 rs10105920 chr8:8648737 A/G cg15556689 chr8:8085844 FLJ10661 0.46 6.27 0.32 1.1e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs8027181 0.839 rs998021 chr15:72999825 T/C cg25632853 chr15:73088954 NA 0.32 6.62 0.34 1.47e-10 Triglyceride levels; LUSC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg11871910 chr12:69753446 YEATS4 -0.68 -10.48 -0.5 2.1e-22 Blood protein levels; LUSC cis rs11051970 1.000 rs6488051 chr12:32532733 G/C cg02745156 chr12:32552066 NA 0.44 7.24 0.37 3.07e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg09365446 chr1:150670422 GOLPH3L 0.46 6.93 0.35 2.16e-11 Melanoma; LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg22166914 chr1:53195759 ZYG11B -0.61 -10.24 -0.49 1.4e-21 Monocyte count; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg24846343 chr22:24311635 DDTL 0.62 13.2 0.59 2.61e-32 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.5 -8.11 -0.41 9.76e-15 IgG glycosylation; LUSC cis rs66679842 1 rs66679842 chr6:88171407 AC/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -6.15 -0.32 2.2e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.21 0.32 1.54e-9 Personality dimensions; LUSC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg20243544 chr17:37824526 PNMT 0.39 5.76 0.3 1.96e-8 Self-reported allergy; LUSC cis rs4664308 0.618 rs62175488 chr2:160892758 T/C cg03641300 chr2:160917029 PLA2R1 -0.48 -7.9 -0.4 4.1e-14 Idiopathic membranous nephropathy; LUSC cis rs1957429 0.520 rs17102258 chr14:65332369 G/A cg23373153 chr14:65346875 NA -0.85 -7.9 -0.4 4.11e-14 Pediatric areal bone mineral density (radius); LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg27535305 chr1:53392650 SCP2 -0.4 -7.44 -0.38 8.64e-13 Monocyte count; LUSC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC trans rs12692738 0.526 rs355871 chr2:165632068 A/G cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.538 rs6454483 chr6:86418283 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.4 6.3 0.33 9.6e-10 Response to antipsychotic treatment; LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg22166914 chr1:53195759 ZYG11B -0.5 -7.92 -0.4 3.64e-14 Monocyte count; LUSC cis rs9902453 0.808 rs4595850 chr17:28206326 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 10.03 0.48 7.03e-21 Coffee consumption (cups per day); LUSC cis rs7582180 0.606 rs4851299 chr2:100954191 C/A cg08017756 chr2:100939284 LONRF2 -0.47 -8.65 -0.43 2.25e-16 Intelligence (multi-trait analysis); LUSC trans rs621559 0.540 rs583116 chr1:43548257 C/G cg17613259 chr2:105484139 NA -0.49 -6.21 -0.32 1.58e-9 Telomere length; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.61e-17 Prudent dietary pattern; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg21548813 chr6:291882 DUSP22 -0.7 -11.71 -0.54 9.09e-27 Menopause (age at onset); LUSC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg08677398 chr8:58056175 NA 0.56 7.07 0.36 9.1e-12 Developmental language disorder (linguistic errors); LUSC cis rs9308433 0.529 rs867445 chr1:214502230 C/G cg06198575 chr1:214491504 SMYD2 0.45 7.11 0.36 7.28e-12 IgG glycosylation; LUSC trans rs11250098 0.642 rs4841460 chr8:10789493 C/G cg15556689 chr8:8085844 FLJ10661 -0.54 -7.65 -0.39 2.24e-13 Morning vs. evening chronotype; LUSC cis rs6570726 0.516 rs9376932 chr6:145729490 T/C cg23711669 chr6:146136114 FBXO30 0.47 7.3 0.37 2.18e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -5.83 -0.3 1.33e-8 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.966 rs1860591 chr4:17577329 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.21 0.32 1.53e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs60843830 1.000 rs7605824 chr2:280819 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.66 -10.75 -0.51 2.45e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9325144 0.647 rs12822023 chr12:39097964 T/C cg13010199 chr12:38710504 ALG10B -0.52 -7.93 -0.4 3.26e-14 Morning vs. evening chronotype; LUSC cis rs3740713 1.000 rs35593189 chr11:18468378 C/T cg07915343 chr11:18477680 LDHAL6A -0.56 -7.06 -0.36 9.87e-12 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs2926702 0.810 rs16936749 chr8:71046183 G/A cg16517358 chr11:46164796 NA 0.37 5.97 0.31 6.03e-9 Non-small cell lung cancer; LUSC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg19346786 chr7:2764209 NA -0.5 -8.56 -0.42 4.06e-16 Height; LUSC trans rs7819412 0.521 rs2409720 chr8:11037903 A/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.25 -0.32 1.27e-9 Triglycerides; LUSC cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg11266682 chr4:10021025 SLC2A9 0.59 10.66 0.5 4.93e-23 Bone mineral density; LUSC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg23625390 chr15:77176239 SCAPER 0.46 6.85 0.35 3.54e-11 Blood metabolite levels; LUSC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9323205 0.765 rs2999387 chr14:51652986 C/G cg23942311 chr14:51606299 NA -0.33 -6.85 -0.35 3.62e-11 Cancer; LUSC cis rs7582180 0.629 rs36103184 chr2:100942634 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -7.55 -0.38 4.16e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg15369054 chr17:80825471 TBCD 0.7 11.95 0.55 1.16e-27 Breast cancer; LUSC trans rs1814175 0.511 rs61905634 chr11:49819736 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.24 -0.8 1.33e-75 Height; LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -8.48 -0.42 7.37e-16 Bipolar disorder and schizophrenia; LUSC cis rs4594175 0.926 rs4349056 chr14:51625819 A/G cg23942311 chr14:51606299 NA 0.31 5.88 0.31 1.01e-8 Cancer; LUSC cis rs28595532 1.000 rs11098451 chr4:119717673 C/T cg11846333 chr4:119757529 SEC24D 0.86 6.35 0.33 6.97e-10 Cannabis dependence symptom count; LUSC cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg18404041 chr3:52824283 ITIH1 0.4 6.94 0.35 2.07e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg06212747 chr3:49208901 KLHDC8B 0.43 5.86 0.31 1.1e-8 Parkinson's disease; LUSC cis rs72781680 1.000 rs6710426 chr2:24159288 A/G cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs4285028 0.948 rs10934565 chr3:121664661 G/A cg11130432 chr3:121712080 ILDR1 -0.64 -9.78 -0.47 4.84e-20 Multiple sclerosis; LUSC trans rs7944735 0.517 rs74763661 chr11:48233772 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.48 0.33 3.28e-10 Intraocular pressure; LUSC cis rs4805272 0.512 rs7245724 chr19:29341679 C/T cg12756686 chr19:29218302 NA 0.56 6.32 0.33 8.42e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg22244940 chr12:132335942 MMP17 0.4 6.03 0.31 4.37e-9 Migraine; LUSC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.47e-12 Lung disease severity in cystic fibrosis; LUSC trans rs35851103 0.600 rs4841662 chr8:11843758 A/G cg27411982 chr8:10470053 RP1L1 -0.49 -7.94 -0.4 3.08e-14 Neuroticism; LUSC cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.74 -0.3 2.1e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs931812 0.825 rs35472498 chr8:101894167 G/A cg20993868 chr7:22813445 NA 0.59 10.22 0.49 1.62e-21 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs11711311 1.000 rs7633832 chr3:113472292 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.69 0.34 9.42e-11 IgG glycosylation; LUSC cis rs8078723 1.000 rs4794823 chr17:38166265 A/T cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.94 -0.36 1.99e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs763121 0.962 rs5757135 chr22:38952573 C/T cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.27e-27 Menopause (age at onset); LUSC trans rs3857536 0.813 rs6903411 chr6:66938288 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs3845702 0.866 rs818659 chr2:180870893 G/A cg01881094 chr2:180872142 CWC22 0.81 10.37 0.49 4.91e-22 Schizophrenia; LUSC cis rs2970818 0.731 rs11063199 chr12:4591854 C/T cg11146114 chr12:4671731 NA 0.57 6.17 0.32 1.99e-9 Phosphorus levels; LUSC cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg00321850 chr1:175162397 KIAA0040 0.45 7.79 0.39 8.55e-14 Alcohol dependence; LUSC cis rs7089973 0.604 rs11196952 chr10:116607592 G/A cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11605924 0.766 rs12419690 chr11:45858584 G/A ch.11.939596F chr11:45881766 CRY2 -0.5 -7.38 -0.37 1.28e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs34375054 0.525 rs1080910 chr12:125608492 T/C cg06287003 chr12:125626642 AACS -0.43 -7.49 -0.38 6.15e-13 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2247341 1.000 rs13124276 chr4:1700368 C/T cg07465881 chr4:1713556 SLBP -0.37 -5.69 -0.3 2.73e-8 Hip circumference adjusted for BMI;Height; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg26921846 chr21:30671131 BACH1 -0.45 -6.22 -0.32 1.49e-9 Cognitive function;Information processing speed; LUSC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg27121462 chr16:89883253 FANCA 0.55 8.8 0.43 7.59e-17 Vitiligo; LUSC cis rs2404602 0.735 rs3765115 chr15:76673716 T/C cg23625390 chr15:77176239 SCAPER -0.61 -9.7 -0.47 9.55e-20 Blood metabolite levels; LUSC cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg20283391 chr11:68216788 NA -0.59 -8.4 -0.42 1.26e-15 Total body bone mineral density; LUSC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg05585544 chr11:47624801 NA 0.41 7.34 0.37 1.64e-12 Subjective well-being; LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7647973 0.626 rs4855849 chr3:49653378 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -7.25 -0.37 2.89e-12 Menarche (age at onset); LUSC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs7223966 1.000 rs2665826 chr17:61944924 A/G cg00945038 chr17:61921165 SMARCD2 0.4 6.02 0.31 4.69e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2274273 0.600 rs10131730 chr14:55840092 C/T cg04306507 chr14:55594613 LGALS3 0.49 9.94 0.48 1.47e-20 Protein biomarker; LUSC cis rs10464366 1.000 rs10464366 chr7:39121500 A/T cg15212455 chr7:39170539 POU6F2 -0.51 -7.62 -0.38 2.63e-13 IgG glycosylation; LUSC cis rs300703 0.654 rs401364 chr2:119493 G/A cg21211680 chr2:198530 NA -0.76 -8.15 -0.41 7.15e-15 Blood protein levels; LUSC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg13902645 chr11:5959945 NA -0.56 -8.03 -0.4 1.7e-14 DNA methylation (variation); LUSC cis rs1062746 0.528 rs12149622 chr16:87340235 A/G cg02258303 chr16:87377426 FBXO31 -0.52 -7.84 -0.39 6.23e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg12564285 chr5:131593104 PDLIM4 -0.46 -7.86 -0.4 5.35e-14 Breast cancer; LUSC cis rs7215564 0.908 rs35844609 chr17:78664850 T/C cg09596252 chr17:78655493 RPTOR 0.53 5.78 0.3 1.71e-8 Myopia (pathological); LUSC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg18876405 chr7:65276391 NA 0.75 13.48 0.59 2.18e-33 Aortic root size; LUSC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg25072359 chr17:41440525 NA -0.62 -9.09 -0.45 8.9e-18 Menopause (age at onset); LUSC cis rs10504229 0.679 rs60869047 chr8:58053221 G/A cg08219700 chr8:58056026 NA 0.46 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); LUSC cis rs4805272 0.512 rs8106166 chr19:29339578 A/G cg12756686 chr19:29218302 NA -0.5 -5.78 -0.3 1.74e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg03146154 chr1:46216737 IPP -0.5 -7.52 -0.38 5.04e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs244731 0.959 rs4976677 chr5:176629546 G/A cg06060754 chr5:176797920 RGS14 -0.62 -8.96 -0.44 2.3e-17 Urate levels in lean individuals; LUSC cis rs12210905 0.925 rs72838243 chr6:26984198 A/T cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs11098499 1.000 rs28419773 chr4:120211061 T/C cg24375607 chr4:120327624 NA 0.73 10.64 0.5 5.66e-23 Corneal astigmatism; LUSC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg20307385 chr11:47447363 PSMC3 -0.47 -6.05 -0.31 3.8e-9 Subjective well-being; LUSC cis rs2295359 1.000 rs2295359 chr1:67635950 G/A cg03340356 chr1:67600835 NA 0.4 6.38 0.33 5.74e-10 Psoriasis; LUSC cis rs9611519 0.894 rs13053242 chr22:41459486 G/A cg03806693 chr22:41940476 POLR3H -0.54 -7.37 -0.37 1.33e-12 Neuroticism; LUSC trans rs13219787 0.915 rs13214703 chr6:27941387 A/G cg12734449 chr6:30038004 PPP1R11 0.78 7.03 0.36 1.18e-11 Mean corpuscular volume;Hemoglobin levels;Mean corpuscular hemoglobin; LUSC cis rs3772130 1.000 rs3732408 chr3:121421179 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.64 9.28 0.45 2.14e-18 Cognitive performance; LUSC cis rs1401999 0.668 rs6806313 chr3:183642152 G/C cg01324343 chr3:183735012 ABCC5 0.68 17.6 0.69 1.6e-49 Anterior chamber depth; LUSC cis rs4243830 0.850 rs12410405 chr1:6581283 C/G cg05709478 chr1:6581295 PLEKHG5 0.56 6.92 0.35 2.28e-11 Body mass index; LUSC cis rs10992471 0.603 rs7045572 chr9:95137964 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.08 -0.4 1.17e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs727505 0.954 rs1009450 chr7:124628723 C/G cg23710748 chr7:124431027 NA -0.37 -6.25 -0.32 1.27e-9 Lewy body disease; LUSC cis rs1451375 0.698 rs1839740 chr7:50646280 C/T cg18232548 chr7:50535776 DDC 0.5 7.58 0.38 3.49e-13 Malaria; LUSC cis rs8114671 0.967 rs4911478 chr20:33782625 A/C cg07148914 chr20:33460835 GGT7 -0.44 -6.55 -0.34 2.12e-10 Height; LUSC cis rs713587 0.875 rs6746013 chr2:25143649 C/G cg15423357 chr2:25149977 NA 0.47 9.5 0.46 4.11e-19 Body mass index in non-asthmatics; LUSC cis rs7089973 0.604 rs58587374 chr10:116597572 A/G cg03647239 chr10:116582469 FAM160B1 0.44 7.16 0.36 5.24e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12618769 0.597 rs72819972 chr2:99035113 A/C cg10123293 chr2:99228465 UNC50 0.47 7.9 0.4 3.99e-14 Bipolar disorder; LUSC cis rs2486288 0.656 rs11632778 chr15:45551056 C/T cg09092052 chr15:45571596 NA 0.46 6.36 0.33 6.52e-10 Glomerular filtration rate; LUSC trans rs11039798 0.687 rs11499938 chr11:48957297 G/A cg03929089 chr4:120376271 NA 0.72 6.87 0.35 3.08e-11 Axial length; LUSC cis rs8060686 0.516 rs7206792 chr16:68168200 C/G cg05110241 chr16:68378359 PRMT7 -0.5 -6.45 -0.33 3.95e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs791888 0.929 rs791887 chr10:89411554 A/G cg10377144 chr10:89419177 PAPSS2 -0.27 -5.92 -0.31 8.13e-9 Magnesium levels; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.66 10.01 0.48 8.59e-21 Lymphocyte counts; LUSC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg16414030 chr3:133502952 NA -0.43 -6.68 -0.34 1.02e-10 Iron status biomarkers; LUSC cis rs698813 0.572 rs4953076 chr2:44480950 G/C cg00619915 chr2:44497795 NA -0.52 -7.34 -0.37 1.61e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.46 -0.38 7.61e-13 Height; LUSC cis rs372883 0.901 rs733610 chr21:30656199 G/A cg24692254 chr21:30365293 RNF160 -0.41 -5.77 -0.3 1.76e-8 Pancreatic cancer; LUSC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg21699342 chr2:239360505 ASB1 0.55 10.46 0.5 2.51e-22 Multiple system atrophy; LUSC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg02034447 chr16:89574710 SPG7 0.43 6.39 0.33 5.63e-10 Multiple myeloma (IgH translocation); LUSC cis rs12421382 0.683 rs10789735 chr11:109431361 A/T cg27471124 chr11:109292789 C11orf87 0.47 7.82 0.39 6.91e-14 Schizophrenia; LUSC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg16384552 chr7:74938386 SPDYE8P -0.61 -9.39 -0.46 9.4e-19 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg07424592 chr7:64974309 NA -0.63 -5.7 -0.3 2.63e-8 Diabetic kidney disease; LUSC cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs478304 0.754 rs2004649 chr11:65380916 G/A cg27068330 chr11:65405492 SIPA1 -0.69 -9.73 -0.47 7.13e-20 Acne (severe); LUSC cis rs983392 0.617 rs667897 chr11:59936979 C/T cg20284999 chr11:59952153 MS4A6A 0.36 6.53 0.34 2.44e-10 Alzheimer's disease (late onset); LUSC trans rs2727020 0.595 rs11040416 chr11:49566429 C/T cg15704280 chr7:45808275 SEPT13 -1.1 -22.35 -0.77 2.55e-68 Coronary artery disease; LUSC cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg04545296 chr12:48745243 ZNF641 0.37 6.79 0.35 5e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg22963979 chr7:1858916 MAD1L1 -0.58 -9.03 -0.44 1.39e-17 Bipolar disorder and schizophrenia; LUSC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg06494592 chr3:125709126 NA -0.52 -5.82 -0.3 1.35e-8 Blood pressure (smoking interaction); LUSC cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg23649088 chr2:200775458 C2orf69 -0.54 -6.89 -0.35 2.72e-11 Schizophrenia; LUSC cis rs10197940 0.789 rs2444256 chr2:152280365 C/T cg06191203 chr2:152266755 RIF1 -0.57 -8.05 -0.4 1.49e-14 Lung cancer; LUSC cis rs9300255 0.569 rs1727320 chr12:123700476 T/A cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg00745463 chr17:30367425 LRRC37B -0.7 -8.52 -0.42 5.45e-16 Hip circumference adjusted for BMI; LUSC trans rs1005277 0.505 rs7069702 chr10:38247359 G/T cg17830980 chr10:43048298 ZNF37B 0.46 7.21 0.37 3.81e-12 Extrinsic epigenetic age acceleration; LUSC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg17718321 chr1:152188247 HRNR -0.38 -6.81 -0.35 4.52e-11 Inflammatory skin disease; LUSC cis rs7833787 0.965 rs7830045 chr8:18700282 A/C cg17701159 chr8:18705777 PSD3 -0.37 -5.96 -0.31 6.32e-9 Obesity-related traits; LUSC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg11344533 chr11:111475393 SIK2 -0.49 -6.89 -0.35 2.86e-11 Primary sclerosing cholangitis; LUSC cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg00631329 chr6:26305371 NA -0.48 -9.6 -0.47 1.98e-19 Educational attainment; LUSC cis rs694739 0.628 rs475032 chr11:64140737 G/C cg26898376 chr11:64110657 CCDC88B -0.32 -6.11 -0.32 2.82e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs2067615 0.579 rs10861657 chr12:107131314 A/G cg15890332 chr12:107067104 RFX4 0.33 6.09 0.32 3.14e-9 Heart rate; LUSC cis rs17828380 1.000 rs35612331 chr15:63494964 T/C cg05507819 chr15:63340323 TPM1 -0.7 -5.89 -0.31 9.42e-9 Social communication problems; LUSC cis rs3126085 0.935 rs6587651 chr1:152193121 G/T cg03465714 chr1:152285911 FLG -0.4 -5.71 -0.3 2.53e-8 Atopic dermatitis; LUSC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg23625390 chr15:77176239 SCAPER 0.5 7.73 0.39 1.31e-13 Blood metabolite levels; LUSC cis rs868036 0.718 rs28587941 chr15:68122509 T/C cg05925327 chr15:68127851 NA -0.38 -6.01 -0.31 4.92e-9 Restless legs syndrome; LUSC cis rs1790761 0.632 rs625978 chr11:67344664 C/T cg24690094 chr11:67383802 NA 0.43 8.51 0.42 5.91e-16 Mean corpuscular volume; LUSC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg06481639 chr22:41940642 POLR3H -0.53 -6.18 -0.32 1.88e-9 Vitiligo; LUSC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg04369109 chr6:150039330 LATS1 -0.58 -8.5 -0.42 6.24e-16 Lung cancer; LUSC trans rs11039798 0.920 rs61448762 chr11:48923756 G/A cg03929089 chr4:120376271 NA 0.73 6.3 0.33 9.27e-10 Axial length; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00472393 chr6:97730957 C6orf167;MIR548H3 -0.55 -6.71 -0.34 8.17e-11 Bipolar disorder and schizophrenia; LUSC cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg02153584 chr22:29168773 CCDC117 0.6 9.05 0.44 1.17e-17 Lymphocyte counts; LUSC cis rs9747201 1.000 rs56051385 chr17:80126712 T/C cg17462356 chr17:80056334 FASN 0.44 5.95 0.31 6.92e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs41271951 0.512 rs77306500 chr1:151080096 G/C cg11822372 chr1:151115635 SEMA6C -0.78 -7.18 -0.37 4.51e-12 Blood protein levels; LUSC cis rs6121246 0.821 rs115585940 chr20:30317902 T/C cg21427119 chr20:30132790 HM13 -0.39 -5.73 -0.3 2.19e-8 Mean corpuscular hemoglobin; LUSC cis rs2288073 0.965 rs6545338 chr2:24422156 C/T cg06627628 chr2:24431161 ITSN2 -0.78 -11.39 -0.53 1.28e-25 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg21770322 chr7:97807741 LMTK2 0.44 7.53 0.38 4.65e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs67460515 0.892 rs11929238 chr3:161045937 A/T cg03342759 chr3:160939853 NMD3 -0.52 -7.42 -0.38 9.59e-13 Parkinson's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24951396 chr12:125473687 DHX37 0.52 7.43 0.38 8.92e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg20283391 chr11:68216788 NA 0.58 8.19 0.41 5.8e-15 Total body bone mineral density; LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg25428297 chr7:1022841 CYP2W1 0.28 5.82 0.3 1.37e-8 Longevity;Endometriosis; LUSC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg06212747 chr3:49208901 KLHDC8B 0.44 5.93 0.31 7.49e-9 Parkinson's disease; LUSC cis rs9469578 1.000 rs16869458 chr6:33714639 C/T cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs2274273 0.624 rs72717738 chr14:55842761 C/G cg04306507 chr14:55594613 LGALS3 0.48 9.63 0.47 1.6e-19 Protein biomarker; LUSC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.58 -8.69 -0.43 1.61e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC cis rs2963155 0.518 rs853177 chr5:142635460 A/G cg17617527 chr5:142782415 NR3C1 0.7 8.24 0.41 3.96e-15 Breast cancer; LUSC cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg08270630 chr22:50330655 NA 0.55 7.1 0.36 7.49e-12 Schizophrenia; LUSC cis rs8017423 0.967 rs11845329 chr14:90727749 C/T cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs1965732 1.000 rs11696000 chr2:3709907 A/G cg19052272 chr2:3704530 ALLC -0.35 -6.68 -0.34 1.02e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg04414720 chr1:150670196 GOLPH3L 0.51 8.18 0.41 5.89e-15 Melanoma; LUSC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg03804128 chr16:635623 NA 0.3 5.83 0.3 1.28e-8 Height; LUSC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg20283391 chr11:68216788 NA -0.53 -7.78 -0.39 9.29e-14 Total body bone mineral density; LUSC cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.03 0.44 1.4e-17 Prudent dietary pattern; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20912066 chr11:107436729 ALKBH8 0.39 6.04 0.31 4.06e-9 Triglycerides; LUSC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg02569458 chr12:86230093 RASSF9 0.58 9.82 0.47 3.54e-20 Major depressive disorder; LUSC trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg06238570 chr21:40685208 BRWD1 0.47 7.11 0.36 7.08e-12 Cognitive function; LUSC trans rs11098499 1.000 rs3749591 chr4:120214030 T/G cg25214090 chr10:38739885 LOC399744 0.47 6.77 0.35 5.73e-11 Corneal astigmatism; LUSC cis rs2012796 0.743 rs12435764 chr14:81836866 A/C cg02996355 chr14:81879375 NA 0.53 7.74 0.39 1.19e-13 Night sleep phenotypes; LUSC cis rs36093844 0.898 rs11234457 chr11:85591041 C/T cg25872744 chr11:85566296 CCDC83 -0.42 -6.2 -0.32 1.64e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs1451882 0.698 rs1376786 chr8:1061074 A/G cg25830660 chr3:197026096 DLG1 0.59 6.96 0.36 1.84e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11214589 0.807 rs2155463 chr11:113242301 T/C cg14159747 chr11:113255604 NA 0.26 6.48 0.33 3.21e-10 Neuroticism; LUSC cis rs10493773 0.775 rs2069208 chr1:86117583 T/C cg17807903 chr1:86174739 ZNHIT6 -0.49 -12.22 -0.56 1.18e-28 Urate levels in overweight individuals; LUSC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.79 -0.57 9.28e-31 Platelet count; LUSC cis rs780094 0.500 rs12995461 chr2:27778167 A/C cg27432699 chr2:27873401 GPN1 0.4 5.65 0.3 3.43e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs4689388 0.609 rs1046319 chr4:6304286 C/T cg00701064 chr4:6280414 WFS1 0.41 7.5 0.38 5.64e-13 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg03146154 chr1:46216737 IPP 0.51 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7618501 0.633 rs4688755 chr3:50064424 G/A cg21659725 chr3:3221576 CRBN -0.64 -10.69 -0.5 3.96e-23 Intelligence (multi-trait analysis); LUSC cis rs9644630 0.870 rs10888165 chr8:19358961 T/C cg01280390 chr8:19363452 CSGALNACT1 0.38 7.24 0.37 3.09e-12 Oropharynx cancer; LUSC trans rs11039798 0.777 rs2202454 chr11:49011009 T/C cg15704280 chr7:45808275 SEPT13 0.81 7.57 0.38 3.71e-13 Axial length; LUSC cis rs2408955 0.522 rs3997 chr12:48481587 T/C cg24011408 chr12:48396354 COL2A1 -0.39 -5.65 -0.3 3.45e-8 Glycated hemoglobin levels; LUSC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg07424592 chr7:64974309 NA 0.69 6.07 0.32 3.4e-9 Diabetic kidney disease; LUSC trans rs2790216 0.526 rs1199093 chr10:59896794 C/G cg04544938 chr11:76092429 PRKRIR -0.39 -6.25 -0.32 1.25e-9 Inflammatory bowel disease; LUSC cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg11890956 chr21:40555474 PSMG1 -0.73 -11.03 -0.52 2.4e-24 Menarche (age at onset); LUSC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 14.53 0.62 2.03e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2580764 0.517 rs2972070 chr2:55301691 G/A cg09592903 chr2:55203963 RTN4 0.45 8.87 0.44 4.58e-17 Mean platelet volume; LUSC cis rs7681440 0.904 rs2301134 chr4:90758945 A/G cg01966878 chr4:90757139 SNCA -0.36 -6.11 -0.32 2.77e-9 Dementia with Lewy bodies; LUSC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg23711669 chr6:146136114 FBXO30 0.71 12.44 0.56 1.93e-29 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06307169 chr17:38296698 CASC3 0.54 8.11 0.41 9.49e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg25767906 chr1:53392781 SCP2 0.45 8.08 0.4 1.2e-14 Monocyte count; LUSC cis rs9790314 0.846 rs7652267 chr3:160998497 A/G cg03342759 chr3:160939853 NMD3 -0.61 -11.12 -0.52 1.16e-24 Morning vs. evening chronotype; LUSC trans rs7613875 0.620 rs11721204 chr3:49982765 C/T cg21659725 chr3:3221576 CRBN 0.57 9.0 0.44 1.7e-17 Body mass index; LUSC cis rs7615952 0.932 rs13325495 chr3:125637416 T/G cg05084668 chr3:125655381 ALG1L -0.8 -11.68 -0.54 1.21e-26 Blood pressure (smoking interaction); LUSC cis rs17685 0.925 rs1057868 chr7:75615006 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -5.82 -0.3 1.35e-8 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4237845 0.537 rs10747786 chr12:58260601 G/T cg00677455 chr12:58241039 CTDSP2 0.7 11.11 0.52 1.29e-24 Intelligence (multi-trait analysis); LUSC cis rs804280 0.662 rs11250164 chr8:11610686 C/T cg26752888 chr8:11627280 NEIL2 0.52 7.27 0.37 2.57e-12 Myopia (pathological); LUSC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg16145915 chr7:1198662 ZFAND2A -0.41 -5.87 -0.31 1.05e-8 Bronchopulmonary dysplasia; LUSC cis rs858239 0.601 rs73272048 chr7:23152653 C/G cg23682824 chr7:23144976 KLHL7 0.4 5.88 0.31 9.71e-9 Cerebrospinal fluid biomarker levels; LUSC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg11965913 chr1:205819406 PM20D1 0.51 7.64 0.39 2.27e-13 Menarche (age at onset); LUSC cis rs7188861 0.681 rs12922409 chr16:11415289 C/T cg00044050 chr16:11439710 C16orf75 0.6 6.3 0.33 9.51e-10 HDL cholesterol; LUSC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg09035930 chr12:129282057 SLC15A4 0.73 16.11 0.66 1.27e-43 Systemic lupus erythematosus; LUSC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg02569458 chr12:86230093 RASSF9 -0.57 -9.75 -0.47 6.41e-20 Major depressive disorder; LUSC cis rs2204008 0.557 rs11520191 chr12:38197057 T/A cg13010199 chr12:38710504 ALG10B 0.69 10.8 0.51 1.59e-23 Bladder cancer; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25860314 chr4:119757220 SEC24D 0.43 6.02 0.31 4.64e-9 Mosquito bite size; LUSC trans rs1493916 0.837 rs9952002 chr18:31414314 C/G cg13755796 chr4:20253514 NA -0.39 -6.04 -0.31 4.22e-9 Life satisfaction; LUSC trans rs7786808 0.564 rs10267128 chr7:158198490 G/A cg02030672 chr11:45687055 CHST1 -0.43 -6.62 -0.34 1.42e-10 Obesity-related traits; LUSC trans rs2786098 0.656 rs12731480 chr1:197529264 T/C cg16005942 chr6:160526640 IGF2R 0.51 6.03 0.31 4.34e-9 Asthma; LUSC cis rs2073300 0.793 rs75758241 chr20:23434696 A/G cg09953122 chr20:23471693 CST8 -0.71 -6.44 -0.33 4.11e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2486288 0.656 rs2413768 chr15:45561984 A/G cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.52 -0.5 1.57e-22 Glomerular filtration rate; LUSC cis rs6459804 1.000 rs6459805 chr7:157510294 T/C cg05731713 chr7:157510257 PTPRN2 0.48 9.12 0.45 7.23e-18 Bipolar disorder and schizophrenia; LUSC trans rs7647973 0.626 rs4855882 chr3:49715354 G/T cg21659725 chr3:3221576 CRBN -0.68 -7.67 -0.39 1.89e-13 Menarche (age at onset); LUSC cis rs9517320 0.515 rs9556972 chr13:99209815 C/T cg07423050 chr13:99094983 FARP1 -0.52 -9.83 -0.47 3.38e-20 Longevity; LUSC cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg04117972 chr1:227635322 NA 0.57 6.58 0.34 1.78e-10 Major depressive disorder; LUSC cis rs3125734 0.633 rs12217669 chr10:63988456 A/G cg09941381 chr10:64027924 RTKN2 0.4 7.35 0.37 1.56e-12 Rheumatoid arthritis; LUSC cis rs8060686 0.565 rs8044328 chr16:68146859 G/C cg05110241 chr16:68378359 PRMT7 -0.51 -6.12 -0.32 2.69e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg09835421 chr16:68378352 PRMT7 -0.54 -6.12 -0.32 2.56e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg19318889 chr4:1322082 MAEA -0.71 -12.52 -0.57 9.8e-30 Obesity-related traits; LUSC cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg22532475 chr10:104410764 TRIM8 0.33 6.92 0.35 2.26e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.36 -0.46 1.25e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6460942 0.908 rs59410610 chr7:12282847 A/G cg06484146 chr7:12443880 VWDE -0.54 -5.82 -0.3 1.41e-8 Coronary artery disease; LUSC cis rs6815814 0.898 rs5743592 chr4:38803063 A/G cg02016764 chr4:38805732 TLR1 -0.53 -6.01 -0.31 4.98e-9 Breast cancer; LUSC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.84 12.77 0.57 1.1e-30 Cognitive test performance; LUSC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.78 -13.72 -0.6 2.75e-34 Total body bone mineral density; LUSC cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.83 -0.39 6.35e-14 Chronic sinus infection; LUSC trans rs8002861 0.935 rs7320988 chr13:44413523 C/T cg12856521 chr11:46389249 DGKZ 0.39 6.35 0.33 7.19e-10 Leprosy; LUSC cis rs9303401 0.615 rs35288118 chr17:56600748 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 12.81 0.57 7.56e-31 Cognitive test performance; LUSC cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg09184832 chr6:79620586 NA -0.44 -7.24 -0.37 3.16e-12 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35146811 0.735 rs6948729 chr7:99787372 A/G cg19116668 chr7:99932089 PMS2L1 -0.33 -5.67 -0.3 3.17e-8 Coronary artery disease; LUSC cis rs13385 0.769 rs13353859 chr5:139620455 A/G cg26211634 chr5:139558579 C5orf32 0.46 7.08 0.36 8.79e-12 Atrial fibrillation; LUSC cis rs6685188 0.925 rs12752037 chr1:205661614 A/C cg24503407 chr1:205819492 PM20D1 -0.4 -5.85 -0.3 1.19e-8 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg10074409 chr1:209979377 IRF6 0.33 6.63 0.34 1.36e-10 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg06481639 chr22:41940642 POLR3H -0.46 -5.67 -0.3 3.09e-8 Vitiligo; LUSC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -7.31 -0.37 1.95e-12 Developmental language disorder (linguistic errors); LUSC cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg24130564 chr14:104152367 KLC1 0.44 6.33 0.33 8.02e-10 Intelligence (multi-trait analysis); LUSC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.96 0.55 1.14e-27 Personality dimensions; LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.47 5.81 0.3 1.45e-8 Renal function-related traits (BUN); LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg22535103 chr8:58192502 C8orf71 -0.58 -7.1 -0.36 7.4e-12 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26975351 chr11:10315761 SBF2 -0.41 -6.28 -0.32 1.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1808579 0.935 rs4800488 chr18:21117571 C/A cg14672496 chr18:21087552 C18orf8 0.37 6.28 0.33 1.05e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.44 -6.12 -0.32 2.64e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9486719 0.857 rs2971606 chr6:97043025 C/G cg06623918 chr6:96969491 KIAA0776 -0.85 -12.48 -0.56 1.3e-29 Migraine;Coronary artery disease; LUSC cis rs67311347 1.000 rs9842564 chr3:40405810 A/G cg13683864 chr3:40499215 RPL14 0.95 15.51 0.65 3.17e-41 Renal cell carcinoma; LUSC cis rs4727027 0.704 rs12704073 chr7:148905067 G/A cg14690467 chr7:148917905 ZNF282 -0.25 -5.66 -0.3 3.19e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2274273 0.522 rs2251366 chr14:55518156 A/G cg04306507 chr14:55594613 LGALS3 0.49 10.52 0.5 1.55e-22 Protein biomarker; LUSC cis rs6940638 0.688 rs6456766 chr6:27019575 G/A cg09904177 chr6:26538194 HMGN4 -0.46 -6.58 -0.34 1.84e-10 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.23e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg02569458 chr12:86230093 RASSF9 0.55 9.43 0.46 7.16e-19 Major depressive disorder; LUSC cis rs4629710 0.592 rs749375 chr6:131553692 C/G cg12700074 chr6:131571435 AKAP7 -0.35 -5.76 -0.3 1.91e-8 Multiple myeloma (IgH translocation); LUSC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg05844789 chr1:228464394 OBSCN -0.3 -5.76 -0.3 1.89e-8 Diastolic blood pressure; LUSC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg13770153 chr20:60521292 NA -0.75 -10.35 -0.49 5.93e-22 Body mass index; LUSC trans rs11764590 0.715 rs55770986 chr7:2087823 T/C cg25206134 chr2:45395956 NA 0.56 6.14 0.32 2.38e-9 Neuroticism; LUSC trans rs11098499 0.863 rs2127823 chr4:120485670 G/T cg25214090 chr10:38739885 LOC399744 0.52 7.7 0.39 1.5700000000000001e-13 Corneal astigmatism; LUSC cis rs2115630 1.000 rs2879828 chr15:85361977 G/T cg11189052 chr15:85197271 WDR73 -0.39 -5.67 -0.3 3.16e-8 P wave terminal force; LUSC cis rs9372253 0.967 rs1055301 chr6:110713042 A/G cg00083206 chr6:110721305 DDO -0.43 -7.6 -0.38 2.97e-13 Platelet distribution width; LUSC cis rs7582180 0.934 rs2309817 chr2:100897674 T/A cg08017756 chr2:100939284 LONRF2 -0.34 -5.74 -0.3 2.15e-8 Intelligence (multi-trait analysis); LUSC trans rs656319 0.647 rs13264668 chr8:9884877 C/T cg21775007 chr8:11205619 TDH -0.45 -6.34 -0.33 7.46e-10 Myopia (pathological); LUSC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg20203395 chr5:56204925 C5orf35 -0.78 -10.48 -0.5 2.01e-22 Initial pursuit acceleration; LUSC cis rs7267979 1.000 rs4815426 chr20:25405186 A/C cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4285028 0.747 rs7648343 chr3:121426195 G/A cg11130432 chr3:121712080 ILDR1 -0.59 -8.53 -0.42 5.25e-16 Multiple sclerosis; LUSC cis rs1355223 0.833 rs11032804 chr11:34680598 C/A cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.75 -0.3 2.07e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11992162 0.560 rs13276386 chr8:11797421 T/A cg21775007 chr8:11205619 TDH 0.44 5.96 0.31 6.26e-9 Monocyte count; LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg10729496 chr3:10149963 C3orf24 0.54 7.1 0.36 7.41e-12 Alzheimer's disease; LUSC cis rs6543140 0.964 rs62154972 chr2:103048738 G/A cg09003973 chr2:102972529 NA 0.55 7.15 0.36 5.37e-12 Blood protein levels; LUSC cis rs2281845 0.791 rs1325313 chr1:201076167 C/T cg22815214 chr1:201083145 CACNA1S 0.52 8.79 0.43 8.33e-17 Permanent tooth development; LUSC cis rs9952991 0.941 rs2542150 chr18:12779763 G/C cg23544223 chr18:12777786 NA 0.59 6.27 0.32 1.15e-9 Inflammatory skin disease; LUSC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg02772935 chr3:125709198 NA -0.48 -5.78 -0.3 1.7e-8 Blood pressure (smoking interaction); LUSC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg15556689 chr8:8085844 FLJ10661 0.68 10.85 0.51 1.06e-23 Mood instability; LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg08999081 chr20:33150536 PIGU 0.52 10.42 0.5 3.46e-22 Glomerular filtration rate (creatinine); LUSC cis rs2279817 0.863 rs28481933 chr1:18026277 A/G cg21791023 chr1:18019539 ARHGEF10L 0.46 6.72 0.35 7.76e-11 Neuroticism; LUSC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15506890 chr2:3487001 NA -0.57 -9.3 -0.45 1.96e-18 Neurofibrillary tangles; LUSC trans rs62103177 0.535 rs4799109 chr18:77675188 A/T cg05926928 chr17:57297772 GDPD1 1.26 14.89 0.63 7.86e-39 Opioid sensitivity; LUSC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg20503657 chr10:835505 NA 0.97 13.55 0.6 1.23e-33 Eosinophil percentage of granulocytes; LUSC trans rs57221529 0.766 rs12521988 chr5:556421 C/T cg25482853 chr8:67687455 SGK3 1.19 19.12 0.72 1.43e-55 Lung disease severity in cystic fibrosis; LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg08219700 chr8:58056026 NA 0.64 8.1 0.41 1.03e-14 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs6946356 chr7:91727385 G/A cg22709100 chr7:91322751 NA 0.4 5.85 0.3 1.17e-8 Breast cancer; LUSC trans rs61931739 0.500 rs6488224 chr12:34537205 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg03929089 chr4:120376271 NA 0.66 6.25 0.32 1.23e-9 Intraocular pressure; LUSC cis rs10654220 1 rs10654220 chr12:123703422 A/AGTT cg13010344 chr12:123464640 ARL6IP4 -0.48 -5.84 -0.3 1.23e-8 Platelet count; LUSC cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.74 -0.65 3.74e-42 Gut microbiome composition (summer); LUSC cis rs1376877 0.519 rs13416670 chr2:204285774 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.51 6.53 0.34 2.46e-10 Subclinical atherosclerosis traits (other); LUSC trans rs1325195 0.920 rs2816170 chr1:179214726 G/A cg11624085 chr17:8464688 MYH10 0.41 6.82 0.35 4.27e-11 IgE grass sensitization; LUSC trans rs10802346 0.545 rs4478780 chr1:246372241 T/C cg22732515 chr19:44031385 ETHE1 0.62 10.32 0.49 7.17e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs11098499 0.865 rs3956464 chr4:120256764 T/C cg09307838 chr4:120376055 NA 0.69 10.47 0.5 2.2e-22 Corneal astigmatism; LUSC cis rs7605827 0.930 rs6732252 chr2:15595473 T/C cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.26e-17 Educational attainment (years of education); LUSC cis rs9311676 0.656 rs55692656 chr3:58383174 A/T cg26110898 chr3:58419937 PDHB 0.39 6.32 0.33 8.19e-10 Systemic lupus erythematosus; LUSC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.9 -0.4 4.2e-14 Height; LUSC cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg09479241 chr17:27052676 TLCD1 0.43 5.78 0.3 1.74e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9549260 0.564 rs9549271 chr13:41295477 T/C cg21288729 chr13:41239152 FOXO1 0.54 7.96 0.4 2.75e-14 Red blood cell count; LUSC cis rs950169 0.960 rs35159785 chr15:84804014 G/A cg17173187 chr15:85201210 NMB 0.37 6.45 0.33 3.94e-10 Schizophrenia; LUSC cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg06550200 chr5:1325588 CLPTM1L -0.67 -11.73 -0.54 7.83e-27 Lung cancer; LUSC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs10464366 0.560 rs12701692 chr7:39135551 A/G cg10621924 chr7:39171070 POU6F2 0.44 6.82 0.35 4.26e-11 IgG glycosylation; LUSC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg08847533 chr14:75593920 NEK9 0.86 16.21 0.66 5.23e-44 Height; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg20887711 chr4:1340912 KIAA1530 0.47 7.17 0.37 4.96e-12 Obesity-related traits; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.65 0.43 2.26e-16 Prudent dietary pattern; LUSC cis rs17828380 0.844 rs34568831 chr15:63444365 C/T cg05507819 chr15:63340323 TPM1 -0.78 -5.91 -0.31 8.37e-9 Social communication problems; LUSC cis rs17270561 0.609 rs7754733 chr6:25745049 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 7.79 0.39 8.71e-14 Iron status biomarkers; LUSC cis rs734999 0.545 rs28690427 chr1:2571823 A/G cg18932078 chr1:2524107 MMEL1 -0.3 -6.47 -0.33 3.48e-10 Ulcerative colitis; LUSC cis rs7829975 0.711 rs4481596 chr8:8704330 G/C cg15556689 chr8:8085844 FLJ10661 0.7 11.34 0.53 1.91e-25 Mood instability; LUSC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs614226 0.872 rs12307148 chr12:120903179 T/C cg21053147 chr12:120880522 NA 0.5 6.01 0.31 4.82e-9 Type 1 diabetes nephropathy; LUSC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg00933542 chr6:150070202 PCMT1 0.33 6.89 0.35 2.85e-11 Lung cancer; LUSC cis rs4654899 0.758 rs1609558 chr1:21525228 C/T cg01072550 chr1:21505969 NA 0.55 8.53 0.42 5.1e-16 Superior frontal gyrus grey matter volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18767321 chr22:39096505 JOSD1 -0.49 -5.97 -0.31 6.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs12908161 1.000 rs56864281 chr15:85357649 C/A cg17173187 chr15:85201210 NMB 0.51 9.44 0.46 6.57e-19 Schizophrenia; LUSC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs3540 0.576 rs12907587 chr15:91045851 G/C cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.71 -0.3 2.48e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs2795502 1.000 rs1581702 chr10:43344246 G/A cg20628663 chr10:43360327 NA 0.76 11.26 0.52 3.79e-25 Blood protein levels; LUSC cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg04025307 chr7:1156635 C7orf50 0.45 6.47 0.33 3.52e-10 Bronchopulmonary dysplasia; LUSC cis rs10992471 0.603 rs10820968 chr9:95106443 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -7.92 -0.4 3.56e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs950169 0.922 rs11633534 chr15:85124642 C/T cg11189052 chr15:85197271 WDR73 0.48 5.86 0.31 1.14e-8 Schizophrenia; LUSC cis rs9300255 0.544 rs1727310 chr12:123660510 A/G cg13010344 chr12:123464640 ARL6IP4 -0.57 -6.79 -0.35 5.23e-11 Neutrophil percentage of white cells; LUSC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg24110177 chr3:50126178 RBM5 0.56 9.27 0.45 2.36e-18 Intelligence (multi-trait analysis); LUSC cis rs897984 0.806 rs10782001 chr16:30942625 G/A cg02466173 chr16:30829666 NA 0.56 11.3 0.53 2.68e-25 Dementia with Lewy bodies; LUSC cis rs9527 0.590 rs2148198 chr10:104915310 A/G cg23093090 chr10:104574429 C10orf26 0.33 5.78 0.3 1.75e-8 Arsenic metabolism; LUSC cis rs9309473 0.519 rs2178154 chr2:73661738 C/T cg20560298 chr2:73613845 ALMS1 0.46 7.18 0.37 4.44e-12 Metabolite levels; LUSC cis rs7712401 0.715 rs401226 chr5:122347726 G/A cg19077854 chr5:122220652 SNX24 -0.41 -8.85 -0.44 5.29e-17 Mean platelet volume; LUSC cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg19920283 chr7:105172520 RINT1 0.6 6.23 0.32 1.38e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg02018176 chr4:1364513 KIAA1530 0.49 8.27 0.41 3.33e-15 Obesity-related traits; LUSC cis rs4268898 0.608 rs72793980 chr2:24428859 T/C cg06627628 chr2:24431161 ITSN2 -0.77 -11.54 -0.53 3.75e-26 Asthma; LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC cis rs10782582 0.609 rs1796827 chr1:76391536 A/T cg10523679 chr1:76189770 ACADM -0.45 -6.55 -0.34 2.23e-10 Daytime sleep phenotypes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03397389 chr1:36397003 EIF2C3 0.47 6.86 0.35 3.38e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs68170813 0.559 rs11769861 chr7:106979559 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.62 -0.47 1.71e-19 Coronary artery disease; LUSC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg15369054 chr17:80825471 TBCD 0.38 6.4 0.33 5.19e-10 Breast cancer; LUSC cis rs16937 0.662 rs10900472 chr1:205181526 A/G cg00857998 chr1:205179979 DSTYK 0.4 5.86 0.31 1.09e-8 Schizophrenia; LUSC cis rs7173743 0.756 rs12903668 chr15:79129320 A/G cg00540400 chr15:79124168 NA 0.36 6.36 0.33 6.71e-10 Coronary artery disease; LUSC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg14668632 chr7:2872130 GNA12 -0.48 -7.02 -0.36 1.27e-11 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03289602 chr19:11708437 ZNF627 -0.44 -6.0 -0.31 5.16e-9 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg19318889 chr4:1322082 MAEA 0.47 7.52 0.38 4.99e-13 Obesity-related traits; LUSC cis rs6163 0.588 rs3818708 chr10:104503584 C/T cg04362960 chr10:104952993 NT5C2 0.45 6.65 0.34 1.17e-10 Waist circumference;Hip circumference; LUSC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs12429206 0.520 rs75594262 chr13:51474385 T/C cg00778807 chr1:43524347 NA -0.36 -5.95 -0.31 6.91e-9 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg18350739 chr11:68623251 NA -0.36 -6.45 -0.33 3.97e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20279784 chr6:112408575 TUBE1;C6orf225 0.65 6.04 0.31 4.16e-9 Cognitive performance; LUSC cis rs2839186 0.843 rs17182671 chr21:47696238 T/C cg05896524 chr21:47604654 C21orf56 0.42 6.2 0.32 1.69e-9 Testicular germ cell tumor; LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg00149659 chr3:10157352 C3orf10 0.9 11.67 0.54 1.28e-26 Alzheimer's disease; LUSC cis rs7914558 0.932 rs4307650 chr10:104959852 C/A cg04362960 chr10:104952993 NT5C2 0.61 9.82 0.47 3.72e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg05585544 chr11:47624801 NA -0.41 -7.17 -0.37 4.95e-12 Subjective well-being; LUSC cis rs7954584 0.546 rs10840630 chr12:122352445 C/T cg01765077 chr12:122356316 WDR66 0.54 7.5 0.38 5.86e-13 Mean corpuscular volume; LUSC cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg12350822 chr6:88032061 C6orf162;GJB7 0.54 10.52 0.5 1.48e-22 Monocyte percentage of white cells; LUSC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg20701182 chr2:24300061 SF3B14 0.89 11.43 0.53 9.08e-26 Lymphocyte counts; LUSC cis rs1003719 0.788 rs9977602 chr21:38450650 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.43 0.53 9.1e-26 Eye color traits; LUSC trans rs12614435 0.512 rs36113194 chr2:179490785 C/T cg14011486 chr1:26737247 LIN28 0.48 6.65 0.34 1.19e-10 Atrial fibrillation; LUSC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg20307385 chr11:47447363 PSMC3 -0.44 -5.8 -0.3 1.5e-8 Subjective well-being; LUSC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.75 0.43 1.09e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg03351412 chr1:154909251 PMVK -0.42 -6.28 -0.33 1.05e-9 Prostate cancer; LUSC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.72 12.81 0.57 8.15e-31 Intelligence (multi-trait analysis); LUSC cis rs4566357 0.615 rs10198406 chr2:227913539 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -8.29 -0.41 2.72e-15 Coronary artery disease; LUSC cis rs66887589 0.934 rs6817317 chr4:120542827 A/G cg24375607 chr4:120327624 NA -0.47 -7.24 -0.37 3.1e-12 Diastolic blood pressure; LUSC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03576123 chr11:487126 PTDSS2 -0.94 -10.06 -0.48 5.76e-21 Body mass index; LUSC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg24399712 chr22:39784796 NA 0.63 11.42 0.53 9.75e-26 Intelligence (multi-trait analysis); LUSC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg14196790 chr5:131705035 SLC22A5 0.45 7.38 0.37 1.27e-12 Breast cancer;Mosquito bite size; LUSC cis rs4474465 0.831 rs7121299 chr11:78189133 G/T cg27205649 chr11:78285834 NARS2 -0.48 -5.72 -0.3 2.42e-8 Alzheimer's disease (survival time); LUSC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.03 0.31 4.3e-9 Schizophrenia; LUSC cis rs10754283 0.967 rs7523046 chr1:90109499 G/A cg21401794 chr1:90099060 LRRC8C 0.64 9.65 0.47 1.33e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1965732 1.000 rs6707320 chr2:3708966 A/G cg19052272 chr2:3704530 ALLC -0.36 -6.85 -0.35 3.49e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1577917 0.958 rs12203457 chr6:86689277 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.28 -0.41 2.9e-15 Response to antipsychotic treatment; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg07507251 chr3:52567010 NT5DC2 0.34 6.72 0.35 7.76e-11 Bipolar disorder; LUSC cis rs9527 0.615 rs7096452 chr10:104736563 G/A cg05855489 chr10:104503620 C10orf26 0.52 8.0 0.4 2.12e-14 Arsenic metabolism; LUSC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg01475377 chr6:109611718 NA -0.44 -7.84 -0.39 6.06e-14 Reticulocyte fraction of red cells; LUSC cis rs709400 0.633 rs8013101 chr14:103951772 G/C cg12935359 chr14:103987150 CKB -0.51 -7.98 -0.4 2.31e-14 Body mass index; LUSC cis rs6906287 0.647 rs11153734 chr6:118726220 A/G cg21191810 chr6:118973309 C6orf204 0.33 6.06 0.31 3.77e-9 Electrocardiographic conduction measures; LUSC trans rs7937682 0.924 rs11213968 chr11:111527629 G/C cg18187862 chr3:45730750 SACM1L 0.55 7.1 0.36 7.64e-12 Primary sclerosing cholangitis; LUSC cis rs6835098 0.509 rs2332655 chr4:174093002 A/G cg08422745 chr4:174089978 GALNT7 0.67 11.02 0.52 2.71e-24 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg07507251 chr3:52567010 NT5DC2 -0.34 -6.67 -0.34 1.04e-10 Bipolar disorder; LUSC cis rs6977660 0.660 rs10269891 chr7:19816063 T/C cg05791153 chr7:19748676 TWISTNB 0.69 7.36 0.37 1.48e-12 Thyroid stimulating hormone; LUSC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg06640241 chr16:89574553 SPG7 0.7 11.11 0.52 1.31e-24 Multiple myeloma (IgH translocation); LUSC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg06740227 chr12:86229804 RASSF9 0.45 7.14 0.36 5.83e-12 Major depressive disorder; LUSC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg07777115 chr5:623756 CEP72 -0.45 -5.65 -0.3 3.48e-8 Obesity-related traits; LUSC cis rs72781680 0.898 rs72782106 chr2:24022009 A/G cg08917208 chr2:24149416 ATAD2B 0.96 9.92 0.48 1.69e-20 Lymphocyte counts; LUSC cis rs10892173 0.846 rs7943887 chr11:117670282 C/G cg21640587 chr11:117668038 DSCAML1 0.36 5.82 0.3 1.35e-8 Myopia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22949040 chr2:204399512 RAPH1 0.43 6.28 0.32 1.05e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.39 0.59 5.01e-33 Allergic disease (asthma, hay fever or eczema); LUSC trans rs7613875 0.600 rs7061 chr3:50114515 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -8.53 -0.42 5.12e-16 Body mass index; LUSC cis rs7954584 0.635 rs11043242 chr12:122356293 G/C cg01765077 chr12:122356316 WDR66 0.54 7.6 0.38 2.96e-13 Mean corpuscular volume; LUSC cis rs950169 0.922 rs12911223 chr15:84831671 G/A cg17173187 chr15:85201210 NMB -0.37 -6.7 -0.34 8.96e-11 Schizophrenia; LUSC cis rs8060686 0.858 rs13334918 chr16:67901343 A/G cg26727032 chr16:67993705 SLC12A4 -0.38 -5.76 -0.3 1.88e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg08213375 chr14:104286397 PPP1R13B -0.51 -10.41 -0.5 3.5e-22 Schizophrenia; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg14159672 chr1:205819179 PM20D1 -0.5 -7.58 -0.38 3.45e-13 Menarche (age at onset); LUSC cis rs7481584 0.581 rs515481 chr11:3047184 A/G cg08508325 chr11:3079039 CARS 0.37 8.27 0.41 3.15e-15 Calcium levels; LUSC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg27494647 chr7:150038898 RARRES2 -0.48 -7.37 -0.37 1.34e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs6500602 0.679 rs736685 chr16:4508606 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 7.41 0.38 1.05e-12 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07134292 chr1:51702069 RNF11 0.43 6.01 0.31 4.88e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9527 0.615 rs17725614 chr10:104685493 G/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.66 -0.34 1.11e-10 Arsenic metabolism; LUSC cis rs1577917 1.000 rs1999852 chr6:86705738 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.57 -0.34 1.94e-10 Response to antipsychotic treatment; LUSC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.8 0.3 1.56e-8 Personality dimensions; LUSC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -8.43 -0.42 1.02e-15 Alzheimer's disease; LUSC cis rs10489202 1.000 rs1060041 chr1:167973976 C/T cg24449463 chr1:168025552 DCAF6 -0.54 -6.92 -0.35 2.34e-11 Schizophrenia; LUSC cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg26116260 chr4:7069785 GRPEL1 0.62 9.91 0.48 1.86e-20 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs7923609 1.000 rs10761727 chr10:64995493 C/T cg01631684 chr10:65280961 REEP3 -0.4 -6.26 -0.32 1.19e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.61 -7.9 -0.4 4.15e-14 Body mass index (adult); LUSC cis rs4689388 0.609 rs1046319 chr4:6304286 C/T cg25554036 chr4:6271136 WFS1 0.41 6.53 0.34 2.41e-10 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.61 0.43 2.95e-16 Height; LUSC cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg08999081 chr20:33150536 PIGU -0.38 -6.88 -0.35 3.03e-11 Coronary artery disease; LUSC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg04352962 chr1:209979756 IRF6 0.5 6.75 0.35 6.6e-11 Cleft lip with or without cleft palate; LUSC cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg24642439 chr20:33292090 TP53INP2 0.5 7.58 0.38 3.43e-13 Height; LUSC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg04450456 chr4:17643702 FAM184B 0.37 6.42 0.33 4.74e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1018836 0.851 rs7007129 chr8:91629790 T/G cg16814680 chr8:91681699 NA -0.79 -13.33 -0.59 8.69e-33 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs10743315 0.643 rs12579951 chr12:19331186 C/T cg02471346 chr12:19282374 PLEKHA5 0.6 6.05 0.31 3.94e-9 Gut microbiota (bacterial taxa); LUSC cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg07148914 chr20:33460835 GGT7 -0.56 -8.54 -0.42 4.68e-16 Glomerular filtration rate (creatinine); LUSC trans rs7726839 0.540 rs4957080 chr5:644552 A/C cg25482853 chr8:67687455 SGK3 -1.1 -15.86 -0.66 1.25e-42 Obesity-related traits; LUSC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg06484146 chr7:12443880 VWDE -0.62 -7.21 -0.37 3.69e-12 Coronary artery disease; LUSC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg25811766 chr13:21894605 NA 0.62 9.61 0.47 1.83e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs2115536 0.730 rs12898642 chr15:80182050 T/C cg00225070 chr15:80189496 MTHFS 0.43 6.18 0.32 1.84e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4474465 0.688 rs4944210 chr11:78282878 C/T cg27205649 chr11:78285834 NARS2 0.56 6.79 0.35 5.06e-11 Alzheimer's disease (survival time); LUSC cis rs180358 0.588 rs2542062 chr11:116680449 G/A cg08985259 chr11:116699649 APOC3 0.3 5.93 0.31 7.39e-9 Multiple sclerosis (severity); LUSC cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg24812749 chr6:127587940 RNF146 0.71 10.21 0.49 1.76e-21 Breast cancer; LUSC cis rs16949788 0.793 rs12439705 chr15:66668003 C/A cg08120210 chr15:66682733 MAP2K1 -0.58 -5.82 -0.3 1.41e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs965469 1.000 rs6051705 chr20:3253143 G/A cg25506879 chr20:3388711 C20orf194 -0.54 -6.31 -0.33 8.79e-10 IFN-related cytopenia; LUSC cis rs13064411 0.696 rs1486897 chr3:113215818 G/A cg18753928 chr3:113234510 CCDC52 -0.54 -8.23 -0.41 4.16e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs4319547 0.695 rs6488939 chr12:122858250 T/C cg23029597 chr12:123009494 RSRC2 -0.7 -9.23 -0.45 3.12e-18 Body mass index; LUSC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg24110177 chr3:50126178 RBM5 -0.57 -9.4 -0.46 8.81e-19 Intelligence (multi-trait analysis); LUSC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs2108225 1.000 rs2108226 chr7:107453279 A/C cg18560240 chr7:107437656 SLC26A3 -0.44 -6.54 -0.34 2.36e-10 Ulcerative colitis; LUSC cis rs11122272 0.701 rs2011383 chr1:231479788 T/A cg06096015 chr1:231504339 EGLN1 0.57 10.02 0.48 7.85e-21 Hemoglobin concentration; LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.11 16.38 0.67 1.12e-44 Gut microbiome composition (summer); LUSC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.83 -0.3 1.34e-8 Tonsillectomy; LUSC cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg18681998 chr4:17616180 MED28 -0.76 -13.35 -0.59 7.4e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs727505 0.909 rs1031957 chr7:124627301 T/C cg23710748 chr7:124431027 NA -0.37 -6.43 -0.33 4.42e-10 Lewy body disease; LUSC cis rs4474465 0.850 rs4944205 chr11:78227790 T/A cg27205649 chr11:78285834 NARS2 0.5 5.75 0.3 2.03e-8 Alzheimer's disease (survival time); LUSC cis rs9473147 0.516 rs9296564 chr6:47494759 A/G cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs4343996 0.967 rs6958390 chr7:3353005 T/C cg21248987 chr7:3385318 SDK1 -0.39 -6.53 -0.34 2.47e-10 Motion sickness; LUSC cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.5 -5.74 -0.3 2.15e-8 Schizophrenia; LUSC cis rs2742234 0.541 rs10899782 chr10:43736361 A/T cg15436174 chr10:43711423 RASGEF1A 0.43 7.01 0.36 1.33e-11 Hirschsprung disease; LUSC cis rs77741769 0.571 rs7969140 chr12:121303626 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.64 0.43 2.42e-16 Mean corpuscular volume; LUSC cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg27247225 chr6:26970382 C6orf41 -0.47 -5.81 -0.3 1.44e-8 Intelligence (multi-trait analysis); LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg18099408 chr3:52552593 STAB1 0.39 6.71 0.34 8.57e-11 Bipolar disorder; LUSC cis rs9865818 0.626 rs12485704 chr3:188109766 C/T cg23651889 chr3:188115336 LPP -0.4 -5.91 -0.31 8.44e-9 Allergic sensitization; LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg11645453 chr3:52864694 ITIH4 0.36 8.63 0.43 2.5e-16 Bipolar disorder; LUSC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg01579765 chr21:45077557 HSF2BP 0.54 11.46 0.53 7.23e-26 Mean corpuscular volume; LUSC trans rs10435719 0.867 rs6999030 chr8:11795308 G/A cg08975724 chr8:8085496 FLJ10661 0.48 7.0 0.36 1.44e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.78e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs9944715 0.911 rs7230154 chr18:43835793 C/T cg01718231 chr17:29326311 RNF135 -0.54 -7.49 -0.38 6.16e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7582720 1.000 rs79539678 chr2:203740938 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs1728785 1.000 rs1170428 chr16:68603988 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.5 0.42 6.47e-16 Ulcerative colitis; LUSC cis rs73198271 0.960 rs17154702 chr8:8609880 C/T cg01851573 chr8:8652454 MFHAS1 0.6 8.17 0.41 6.27e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4144743 1.000 rs67615769 chr17:45325478 A/G cg18085866 chr17:45331354 ITGB3 -0.73 -7.75 -0.39 1.12e-13 Body mass index; LUSC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg15445000 chr17:37608096 MED1 -0.38 -6.62 -0.34 1.42e-10 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.65 -11.36 -0.53 1.59e-25 Menopause (age at onset); LUSC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg11764359 chr7:65958608 NA 0.58 8.91 0.44 3.25e-17 Aortic root size; LUSC cis rs73110464 0.505 rs2682296 chr12:53308265 G/A cg10046767 chr12:53297693 KRT8 0.46 6.46 0.33 3.61e-10 Cancer (pleiotropy); LUSC trans rs656319 0.625 rs4526366 chr8:9890179 C/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.43 -0.38 9.21e-13 Myopia (pathological); LUSC cis rs25645 0.502 rs7209742 chr17:38108708 A/G cg17467752 chr17:38218738 THRA 0.41 5.69 0.3 2.73e-8 Myeloid white cell count; LUSC cis rs7296418 0.961 rs1790122 chr12:123606739 G/A cg00376283 chr12:123451042 ABCB9 0.8 12.14 0.55 2.4e-28 Platelet count; LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17840061 chr6:70577478 COL19A1 -0.52 -6.82 -0.35 4.34e-11 Bipolar disorder and schizophrenia; LUSC cis rs9807989 0.801 rs6752482 chr2:102967858 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.9 0.31 9.04e-9 Asthma; LUSC cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg19784903 chr17:45786737 TBKBP1 -0.43 -6.15 -0.32 2.18e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg07211511 chr3:129823064 LOC729375 -0.63 -8.24 -0.41 3.95e-15 Blood pressure (smoking interaction); LUSC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg23985595 chr17:80112537 CCDC57 -0.31 -5.98 -0.31 5.8e-9 Life satisfaction; LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg10360139 chr7:1886902 MAD1L1 -0.39 -5.81 -0.3 1.44e-8 Bipolar disorder and schizophrenia; LUSC cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg23583168 chr7:148888333 NA 0.86 16.22 0.66 5e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg15704280 chr7:45808275 SEPT13 -1.02 -19.49 -0.73 4.84e-57 Height; LUSC trans rs7647973 0.626 rs11130217 chr3:49737323 A/G cg21659725 chr3:3221576 CRBN -0.67 -7.97 -0.4 2.5e-14 Menarche (age at onset); LUSC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg23649088 chr2:200775458 C2orf69 0.53 7.23 0.37 3.26e-12 Schizophrenia; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg18538332 chr22:24372958 LOC391322 -0.47 -8.07 -0.4 1.31e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg20573242 chr4:122745356 CCNA2 0.65 9.59 0.46 2.18e-19 Type 2 diabetes; LUSC cis rs9443189 0.526 rs775060 chr6:76373567 G/A cg01950844 chr6:76311363 SENP6 -0.68 -6.8 -0.35 4.89e-11 Prostate cancer; LUSC trans rs8072100 0.967 rs4239163 chr17:45755954 C/T cg03886242 chr7:26192032 NFE2L3 -0.38 -6.26 -0.32 1.17e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg08859206 chr1:53392774 SCP2 0.53 9.22 0.45 3.44e-18 Monocyte count; LUSC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.56 0.34 2e-10 Neutrophil percentage of white cells; LUSC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg03264133 chr6:25882463 NA -0.45 -7.56 -0.38 3.94e-13 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg20891558 chr2:74357851 NA 0.78 14.27 0.62 2.1e-36 Gestational age at birth (maternal effect); LUSC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -12.67 -0.57 2.58e-30 Hemoglobin concentration; LUSC cis rs12200782 1.000 rs12204145 chr6:26600156 C/T cg11502198 chr6:26597334 ABT1 -0.76 -5.73 -0.3 2.24e-8 Small cell lung carcinoma; LUSC cis rs6964587 1.000 rs13231578 chr7:91663266 C/T cg17063962 chr7:91808500 NA 0.6 9.71 0.47 8.83e-20 Breast cancer; LUSC cis rs73200209 0.744 rs7136498 chr12:116483993 T/G cg01776926 chr12:116560359 MED13L -0.5 -5.97 -0.31 6.1e-9 Total body bone mineral density; LUSC cis rs7000551 0.778 rs2469760 chr8:22365945 A/G cg12081754 chr8:22256438 SLC39A14 0.42 6.4 0.33 5.13e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs897080 0.552 rs1067365 chr2:44655398 G/A cg00619915 chr2:44497795 NA -0.43 -6.37 -0.33 6.39e-10 Height; LUSC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg17252645 chr8:143867129 LY6D 0.38 6.78 0.35 5.63e-11 Urinary tract infection frequency; LUSC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg18681998 chr4:17616180 MED28 0.84 15.71 0.65 5.11e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12618769 0.652 rs17034171 chr2:99221095 A/G cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.5 -0.46 4.24e-19 Chronic sinus infection; LUSC cis rs908922 0.676 rs4845780 chr1:152488846 T/G cg20991723 chr1:152506922 NA 0.53 10.17 0.49 2.39e-21 Hair morphology; LUSC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 10.41 0.5 3.59e-22 Hip circumference adjusted for BMI; LUSC cis rs7534801 0.579 rs10803244 chr1:244908049 G/A cg20597013 chr1:244894274 NA -0.4 -6.06 -0.31 3.67e-9 Longitudinal change in brain amyloid plaque burden; LUSC cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg01420254 chr6:26195488 NA -0.63 -7.06 -0.36 9.94e-12 Gout;Renal underexcretion gout; LUSC cis rs9653442 0.564 rs10185510 chr2:100790581 C/T cg07810366 chr2:100720526 AFF3 -0.44 -7.49 -0.38 6.14e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4423214 0.592 rs10898223 chr11:71219264 G/A cg05163923 chr11:71159392 DHCR7 -0.7 -7.3 -0.37 2.12e-12 Vitamin D levels; LUSC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg15352829 chr14:105391018 PLD4 -0.42 -8.9 -0.44 3.73e-17 Rheumatoid arthritis; LUSC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.7 -0.43 1.56e-16 Lung cancer; LUSC cis rs2692947 0.711 rs34639392 chr2:96508976 T/C cg23100626 chr2:96804247 ASTL 0.26 6.31 0.33 8.96e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6545883 0.929 rs1186707 chr2:61673520 C/A cg15711740 chr2:61764176 XPO1 -0.45 -6.87 -0.35 3.09e-11 Tuberculosis; LUSC cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg03146154 chr1:46216737 IPP 0.52 7.62 0.38 2.68e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6547741 1.000 rs13026621 chr2:27807624 G/A cg12559939 chr2:27858050 GPN1 0.41 6.45 0.33 3.94e-10 Oral cavity cancer; LUSC cis rs9354352 0.784 rs2062327 chr6:66689923 C/G cg07460842 chr6:66804631 NA -0.62 -8.95 -0.44 2.44e-17 Initial pursuit acceleration in psychotic disorders; LUSC cis rs2219968 0.701 rs34965401 chr8:78991957 C/G cg00738934 chr8:78996279 NA 0.42 7.61 0.38 2.9e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs7267979 1.000 rs2184000 chr20:25395878 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs747782 0.527 rs7113857 chr11:48141859 G/T cg03929089 chr4:120376271 NA 0.69 6.32 0.33 8.25e-10 Intraocular pressure; LUSC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg24789503 chr3:195384528 SDHAP2 -0.61 -6.98 -0.36 1.59e-11 Lung disease severity in cystic fibrosis; LUSC cis rs3925075 0.966 rs12935192 chr16:31359330 G/A cg02846316 chr16:31340340 ITGAM 0.33 6.0 0.31 5e-9 IgA nephropathy; LUSC cis rs6500602 0.727 rs11076836 chr16:4569331 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.6 0.38 2.93e-13 Schizophrenia; LUSC cis rs1419980 0.643 rs10743997 chr12:7798565 A/C cg10578777 chr12:7781093 NA 0.61 5.73 0.3 2.19e-8 HDL cholesterol levels; LUSC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg21984481 chr17:79567631 NPLOC4 -0.72 -15.07 -0.64 1.65e-39 Eye color traits; LUSC cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg18196295 chr10:418757 DIP2C 0.49 8.06 0.4 1.38e-14 Psychosis in Alzheimer's disease; LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg16647868 chr5:131706066 SLC22A5 0.34 5.71 0.3 2.51e-8 Blood metabolite levels; LUSC cis rs4986172 0.726 rs12946454 chr17:43208121 A/T cg10701640 chr17:43249399 NA 0.45 9.47 0.46 5.36e-19 Height; LUSC cis rs28374715 0.528 rs7181982 chr15:41623020 C/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -22.54 -0.78 4.9e-69 Ulcerative colitis; LUSC cis rs73206853 0.841 rs7961345 chr12:111081598 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.51 0.34 2.76e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7572733 0.534 rs1435568 chr2:198762879 T/C cg00792783 chr2:198669748 PLCL1 0.46 6.19 0.32 1.79e-9 Dermatomyositis; LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg08888203 chr3:10149979 C3orf24 0.59 8.2 0.41 5.23e-15 Alzheimer's disease; LUSC cis rs4654899 1.000 rs6426668 chr1:21396596 T/C cg01072550 chr1:21505969 NA -0.53 -8.02 -0.4 1.78e-14 Superior frontal gyrus grey matter volume; LUSC trans rs643955 0.609 rs13259465 chr8:9982953 C/G cg21775007 chr8:11205619 TDH -0.48 -6.47 -0.33 3.44e-10 Systemic lupus erythematosus; LUSC cis rs17818399 0.533 rs4384837 chr2:46789514 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.53 -7.68 -0.39 1.76e-13 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg27277848 chr15:40575356 NA -0.41 -6.09 -0.32 3.11e-9 Electrocardiographic conduction measures; LUSC cis rs7605827 0.930 rs4668911 chr2:15610650 A/C cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs2832191 0.967 rs2251377 chr21:30530599 T/C cg08807101 chr21:30365312 RNF160 0.68 11.44 0.53 8.68e-26 Dental caries; LUSC cis rs5758659 0.967 rs5751250 chr22:42639645 T/G cg05082376 chr22:42548792 NA -0.4 -6.6 -0.34 1.61e-10 Cognitive function; LUSC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg17554472 chr22:41940697 POLR3H -0.47 -5.75 -0.3 1.97e-8 Vitiligo; LUSC cis rs734999 0.588 rs745367 chr1:2524457 T/C cg18932078 chr1:2524107 MMEL1 0.29 6.43 0.33 4.29e-10 Ulcerative colitis; LUSC cis rs34779708 0.966 rs12782948 chr10:35450607 G/A cg03585969 chr10:35415529 CREM 0.62 9.27 0.45 2.43e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg06873352 chr17:61820015 STRADA 0.68 11.51 0.53 4.9e-26 Prudent dietary pattern; LUSC cis rs4423214 0.921 rs11603330 chr11:71153459 C/A cg05163923 chr11:71159392 DHCR7 0.69 10.49 0.5 1.88e-22 Vitamin D levels; LUSC trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg17470723 chr8:74884337 TCEB1 0.52 8.06 0.4 1.33e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs72627509 0.951 rs72606404 chr4:57841213 G/C cg26694713 chr4:57773883 REST 0.49 5.68 0.3 2.93e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg10609677 chr17:41278573 BRCA1;NBR2 0.36 5.86 0.31 1.09e-8 Menopause (age at onset); LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -6.47 -0.33 3.45e-10 Longevity;Endometriosis; LUSC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg03929089 chr4:120376271 NA -1.03 -20.11 -0.74 1.74e-59 Height; LUSC trans rs9329221 0.597 rs17751178 chr8:10116730 A/G cg15556689 chr8:8085844 FLJ10661 0.52 7.4 0.38 1.09e-12 Neuroticism; LUSC cis rs1568889 1.000 rs1568889 chr11:28009463 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.58 8.27 0.41 3.16e-15 Bipolar disorder; LUSC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg07701084 chr6:150067640 NUP43 0.57 8.69 0.43 1.6e-16 Lung cancer; LUSC cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg01483505 chr11:975446 AP2A2 0.43 6.0 0.31 5.08e-9 Alzheimer's disease (late onset); LUSC cis rs7647973 0.626 rs11709734 chr3:49745235 G/A cg03060546 chr3:49711283 APEH 0.65 7.67 0.39 1.84e-13 Menarche (age at onset); LUSC trans rs116175374 0.793 rs77354826 chr2:31431980 C/T cg15543616 chr12:5019024 KCNA1 -0.77 -6.01 -0.31 4.9e-9 Endometriosis; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg05564831 chr3:52568323 NT5DC2 0.37 6.63 0.34 1.33e-10 Electroencephalogram traits; LUSC cis rs11971779 0.555 rs6950143 chr7:139054418 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9283706 0.594 rs7735834 chr5:66337444 A/G cg11590213 chr5:66331682 MAST4 -0.45 -6.73 -0.35 7.4e-11 Coronary artery disease; LUSC trans rs6502050 0.765 rs6502075 chr17:80121813 G/A cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs7173743 0.518 rs12899452 chr15:79112550 T/A cg15571903 chr15:79123663 NA 0.31 5.76 0.3 1.86e-8 Coronary artery disease; LUSC cis rs4363385 0.531 rs11205188 chr1:153053645 A/T cg00922841 chr1:152955080 SPRR1A -0.4 -6.67 -0.34 1.04e-10 Inflammatory skin disease; LUSC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.646 rs8067682 chr17:57219391 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.44 6.64 0.34 1.25e-10 Cognitive test performance; LUSC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg13607699 chr17:42295918 UBTF 0.7 11.02 0.52 2.73e-24 Total body bone mineral density; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg11645453 chr3:52864694 ITIH4 -0.34 -7.97 -0.4 2.58e-14 Bipolar disorder; LUSC cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg06637938 chr14:75390232 RPS6KL1 -0.53 -8.35 -0.42 1.89e-15 Height; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg06873352 chr17:61820015 STRADA -0.6 -10.29 -0.49 9.13e-22 Prudent dietary pattern; LUSC cis rs17286411 0.750 rs2288030 chr16:71914107 G/A cg03805757 chr16:71968109 PKD1L3 0.42 6.89 0.35 2.72e-11 Blood protein levels; LUSC trans rs8072100 0.790 rs7222225 chr17:45693497 A/G cg04995722 chr7:26192034 NFE2L3 0.42 6.59 0.34 1.7e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1577917 0.958 rs12665542 chr6:86544443 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.79 -0.43 7.94e-17 Response to antipsychotic treatment; LUSC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg22484793 chr3:52261325 TLR9 0.26 6.04 0.31 4.13e-9 Electroencephalogram traits; LUSC cis rs7954584 0.635 rs7137218 chr12:122342877 G/T cg21016266 chr12:122356598 WDR66 0.57 8.62 0.43 2.82e-16 Mean corpuscular volume; LUSC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg04398451 chr17:18023971 MYO15A -0.49 -8.18 -0.41 6.05e-15 Total body bone mineral density; LUSC cis rs10788264 0.544 rs10788269 chr10:124022870 A/G cg09507567 chr10:124027408 NA 0.53 9.3 0.45 1.84e-18 Total body bone mineral density; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg14893161 chr1:205819251 PM20D1 1.02 24.42 0.8 2.7e-76 Menarche (age at onset); LUSC cis rs7264396 0.790 rs2425096 chr20:34308588 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.52 -0.46 3.57e-19 Total cholesterol levels; LUSC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg17554472 chr22:41940697 POLR3H -0.46 -5.78 -0.3 1.67e-8 Vitiligo; LUSC trans rs12692738 0.526 rs355866 chr2:165630823 G/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2274273 0.840 rs7144737 chr14:55822946 C/T cg04306507 chr14:55594613 LGALS3 0.55 11.98 0.55 9.68e-28 Protein biomarker; LUSC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg15110403 chr19:17392923 ANKLE1 0.52 7.3 0.37 2.12e-12 Systemic lupus erythematosus; LUSC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg07936489 chr17:37558343 FBXL20 0.72 10.01 0.48 8.24e-21 Glomerular filtration rate (creatinine); LUSC trans rs6993770 0.813 rs4734875 chr8:106554737 A/G cg03716822 chr8:38126029 PPAPDC1B 0.46 5.97 0.31 5.95e-9 Interleukin-12p70 levels;Plateletcrit;Vascular endothelial growth factor levels;Platelet distribution width;Platelet count;Mean platelet volume; LUSC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg04586622 chr2:25135609 ADCY3 0.43 9.11 0.45 7.9e-18 Body mass index; LUSC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg04013166 chr16:89971882 TCF25 0.54 6.03 0.31 4.38e-9 Skin colour saturation; LUSC cis rs11209002 0.614 rs7544189 chr1:67568351 C/T cg02640540 chr1:67518911 SLC35D1 0.63 8.8 0.43 7.73e-17 Crohn's disease; LUSC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg12412775 chr1:25698385 RHCE -0.3 -6.17 -0.32 1.94e-9 Erythrocyte sedimentation rate; LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg20295408 chr7:1910781 MAD1L1 -0.45 -6.48 -0.33 3.28e-10 Bipolar disorder and schizophrenia; LUSC cis rs13315871 0.929 rs4560319 chr3:58386274 C/T cg20936604 chr3:58311152 NA -0.67 -6.29 -0.33 9.73e-10 Cholesterol, total; LUSC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg13939156 chr17:80058883 NA 0.34 6.69 0.34 9.5e-11 Life satisfaction; LUSC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg17948913 chr5:572064 NA 0.37 5.65 0.3 3.4e-8 Obesity-related traits; LUSC cis rs244731 0.920 rs244707 chr5:176555636 A/T cg06060754 chr5:176797920 RGS14 0.58 7.83 0.39 6.58e-14 Urate levels in lean individuals; LUSC cis rs2932538 0.922 rs3790612 chr1:113084146 G/A cg22162597 chr1:113214053 CAPZA1 0.71 10.22 0.49 1.66e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs9309473 0.519 rs12618600 chr2:73890682 T/C cg20560298 chr2:73613845 ALMS1 0.48 7.31 0.37 1.99e-12 Metabolite levels; LUSC cis rs9638182 0.666 rs12531645 chr7:73023881 G/A cg07452164 chr7:72993570 TBL2 0.48 6.7 0.34 9.01e-11 Triglycerides; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04498971 chr17:56084468 SFRS1 0.46 6.35 0.33 7.14e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 14.7 0.63 4.49e-38 Platelet count; LUSC cis rs11153730 0.503 rs12212582 chr6:118626480 A/G cg21191810 chr6:118973309 C6orf204 0.34 5.87 0.31 1.04e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); LUSC cis rs10197940 0.662 rs6735771 chr2:152273503 G/A cg06191203 chr2:152266755 RIF1 0.52 7.13 0.36 6.27e-12 Lung cancer; LUSC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg03929089 chr4:120376271 NA -0.93 -16.02 -0.66 2.85e-43 Height; LUSC cis rs8072100 0.967 rs7219303 chr17:45737701 A/G cg08085267 chr17:45401833 C17orf57 0.54 8.87 0.44 4.44e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg10792982 chr14:105748885 BRF1 0.47 8.3 0.41 2.56e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg18827107 chr12:86230957 RASSF9 -0.5 -7.46 -0.38 7.62e-13 Major depressive disorder; LUSC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg18479299 chr3:125709523 NA -0.5 -5.7 -0.3 2.7e-8 Blood pressure (smoking interaction); LUSC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg23711669 chr6:146136114 FBXO30 -0.79 -13.87 -0.6 7.6e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs9926296 0.632 rs7184315 chr16:89799373 C/G cg26513180 chr16:89883248 FANCA -0.57 -8.83 -0.43 6.19e-17 Vitiligo; LUSC trans rs61931739 0.635 rs1486884 chr12:33908876 A/T cg26384229 chr12:38710491 ALG10B -0.5 -7.63 -0.39 2.48e-13 Morning vs. evening chronotype; LUSC cis rs1461503 0.780 rs75981430 chr11:122842469 A/C cg27398637 chr11:122830231 C11orf63 -0.4 -6.46 -0.33 3.72e-10 Menarche (age at onset); LUSC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg10018233 chr7:150070692 REPIN1 0.37 6.45 0.33 3.98e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs6541297 0.645 rs4846918 chr1:230300586 A/G cg05784532 chr1:230284198 GALNT2 -0.57 -6.88 -0.35 2.98e-11 Coronary artery disease; LUSC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg06108461 chr20:60628389 TAF4 -1.01 -17.29 -0.69 2.65e-48 Body mass index; LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg16510040 chr1:40042432 PABPC4 -0.56 -6.02 -0.31 4.62e-9 Schizophrenia; LUSC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg19912559 chr1:40204330 PPIE -0.53 -8.03 -0.4 1.68e-14 Blood protein levels; LUSC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg14552801 chr7:65878734 NA 0.45 6.33 0.33 8.04e-10 Aortic root size; LUSC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs225245 0.782 rs225293 chr17:33925906 A/G cg05299278 chr17:33885742 SLFN14 0.31 6.82 0.35 4.37e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs10763170 0.669 rs11004721 chr10:56824909 C/G cg10538533 chr12:53074328 KRT1 0.3 5.97 0.31 6e-9 Sporadic pituitary adenoma; LUSC cis rs10779751 0.734 rs2791658 chr1:11127871 A/G cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs7131987 0.868 rs10771508 chr12:29414211 G/A cg09582351 chr12:29534625 ERGIC2 -0.3 -6.25 -0.32 1.28e-9 QT interval; LUSC cis rs354225 0.544 rs4641979 chr2:54811917 G/A cg01766943 chr2:54829624 SPTBN1 0.48 7.95 0.4 2.85e-14 Schizophrenia; LUSC trans rs4650994 0.507 rs2811312 chr1:178617603 A/G cg05059571 chr16:84539110 KIAA1609 0.47 8.83 0.44 6.21e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs9462027 0.583 rs9469862 chr6:34729848 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.93 -0.31 7.62e-9 Systemic lupus erythematosus; LUSC cis rs9929218 1.000 rs7186084 chr16:68816260 C/G cg02972257 chr16:68554789 NA -0.43 -5.74 -0.3 2.12e-8 Colorectal cancer; LUSC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg09165964 chr15:75287851 SCAMP5 -1.16 -19.39 -0.73 1.27e-56 Blood trace element (Zn levels); LUSC trans rs7824557 0.701 rs4568582 chr8:11160495 A/T cg06636001 chr8:8085503 FLJ10661 0.51 7.67 0.39 1.84e-13 Retinal vascular caliber; LUSC cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg20019365 chr2:219134978 PNKD;AAMP 0.42 6.5 0.34 2.88e-10 Colorectal cancer; LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg16132339 chr22:24313637 DDTL;DDT 0.41 6.39 0.33 5.59e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg05347473 chr6:146136440 FBXO30 0.46 7.97 0.4 2.55e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg26384229 chr12:38710491 ALG10B 0.88 15.03 0.64 2.3e-39 Bladder cancer; LUSC cis rs603424 0.551 rs646767 chr10:102084897 A/G cg10365880 chr10:102089681 PKD2L1 -0.55 -7.04 -0.36 1.08e-11 Phospholipid levels (plasma);Palmitic acid (16:0) levels;Palmitoleic acid (16:1n-7) levels;Mean platelet volume;Serum metabolite levels;Blood metabolite levels;Vaccenic acid (18:1n-7) levels;Metabolic traits;Coronary artery disease;Blood metabolite ratios;Glycerophospholipid levels; LUSC cis rs4595586 0.525 rs4441057 chr12:39420620 T/A cg13010199 chr12:38710504 ALG10B 0.45 6.4 0.33 5.12e-10 Morning vs. evening chronotype; LUSC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg10802521 chr3:52805072 NEK4 -0.52 -8.38 -0.42 1.51e-15 Bipolar disorder; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg04287289 chr16:89883240 FANCA -0.48 -7.18 -0.37 4.64e-12 Vitiligo; LUSC cis rs9646944 0.501 rs13030642 chr2:103091585 C/A cg20060108 chr2:102954350 IL1RL1 0.47 6.25 0.32 1.24e-9 Blood protein levels; LUSC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg18252515 chr7:66147081 NA 1.2 13.62 0.6 6.4e-34 Diabetic kidney disease; LUSC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg21435336 chr19:17392852 ANKLE1 -0.47 -6.49 -0.33 3.15e-10 Systemic lupus erythematosus; LUSC cis rs2115630 0.905 rs6496401 chr15:85297793 A/T cg11189052 chr15:85197271 WDR73 -0.45 -6.48 -0.33 3.35e-10 P wave terminal force; LUSC cis rs8062405 0.824 rs62034324 chr16:28536762 T/C cg16576597 chr16:28551801 NUPR1 0.29 5.75 0.3 2.01e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs8038465 0.594 rs55816897 chr15:73869767 G/T cg15420318 chr15:73925796 NPTN 0.55 9.33 0.45 1.53e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg12257692 chr3:49977190 RBM6 0.25 6.82 0.35 4.34e-11 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg06636001 chr8:8085503 FLJ10661 0.68 11.49 0.53 5.44e-26 Mood instability; LUSC cis rs7119038 0.865 rs10892299 chr11:118726843 C/T cg19308663 chr11:118741387 NA 0.34 5.65 0.3 3.47e-8 Sjögren's syndrome; LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg05025164 chr4:1340916 KIAA1530 0.47 7.32 0.37 1.89e-12 Obesity-related traits; LUSC cis rs4280164 0.551 rs3212242 chr14:24810401 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.55 -6.86 -0.35 3.38e-11 Parent of origin effect on language impairment (paternal); LUSC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg25036284 chr2:26402008 FAM59B -0.68 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC cis rs12908161 0.920 rs35738019 chr15:85280210 T/C cg17507749 chr15:85114479 UBE2QP1 0.54 6.73 0.35 7.18e-11 Schizophrenia; LUSC cis rs394563 0.534 rs388335 chr6:149791986 T/C cg03678062 chr6:149772716 ZC3H12D -0.35 -6.24 -0.32 1.3e-9 Dupuytren's disease; LUSC cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg01657329 chr11:68192670 LRP5 -0.43 -6.35 -0.33 7.09e-10 Total body bone mineral density; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg06795559 chr20:5931181 MCM8;TRMT6 0.62 6.41 0.33 4.98e-10 Myocardial infarction; LUSC cis rs2197308 0.740 rs11182251 chr12:37919611 C/T cg13010199 chr12:38710504 ALG10B -0.6 -9.31 -0.45 1.8e-18 Morning vs. evening chronotype; LUSC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs10927875 0.662 rs698893 chr1:16302982 C/T cg21385522 chr1:16154831 NA 0.54 8.28 0.41 2.99e-15 Dilated cardiomyopathy; LUSC cis rs9325144 0.560 rs13377717 chr12:38639474 T/A cg13010199 chr12:38710504 ALG10B -0.54 -8.16 -0.41 6.81e-15 Morning vs. evening chronotype; LUSC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg08975724 chr8:8085496 FLJ10661 -0.54 -7.5 -0.38 5.66e-13 Neuroticism; LUSC cis rs34779708 0.931 rs7099593 chr10:35366878 A/C cg04310649 chr10:35416472 CREM -0.41 -6.54 -0.34 2.32e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11098499 0.909 rs28555550 chr4:120211040 C/G cg09307838 chr4:120376055 NA 0.72 10.36 0.49 5.25e-22 Corneal astigmatism; LUSC cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg13256891 chr4:100009986 ADH5 0.47 6.46 0.33 3.62e-10 Alcohol dependence; LUSC cis rs7223966 1.000 rs9901507 chr17:61765524 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.27 0.37 2.56e-12 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs2514895 0.660 rs56297939 chr11:127112010 G/A cg22738642 chr12:43137977 NA 0.5 6.26 0.32 1.17e-9 IgG glycosylation; LUSC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg18230493 chr5:56204884 C5orf35 -0.79 -12.52 -0.57 9.14e-30 Initial pursuit acceleration; LUSC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg24838063 chr12:130822603 PIWIL1 0.69 10.79 0.51 1.69e-23 Menopause (age at onset); LUSC cis rs7954584 0.604 rs34159444 chr12:122416667 A/G cg21016266 chr12:122356598 WDR66 0.6 9.11 0.45 7.92e-18 Mean corpuscular volume; LUSC trans rs12200782 1.000 rs12205909 chr6:26630999 G/A cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC cis rs472402 0.580 rs7720479 chr5:6640049 A/G cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.53 -7.7 -0.39 1.54e-13 Response to amphetamines; LUSC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg13319975 chr6:146136371 FBXO30 0.71 11.26 0.52 3.93e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs28647808 0.786 rs28649804 chr9:136257709 C/T cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs2404602 0.692 rs8037005 chr15:76951109 C/T cg26408565 chr15:76604113 ETFA -0.48 -7.63 -0.39 2.4e-13 Blood metabolite levels; LUSC cis rs362272 0.545 rs3135145 chr4:3299504 T/C cg14583973 chr4:3374767 RGS12 0.35 7.27 0.37 2.6e-12 Serum sulfate level; LUSC cis rs9522267 0.535 rs9522303 chr13:112237301 T/C cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 3e-8 Hepatitis; LUSC cis rs11642862 0.901 rs11647243 chr16:30965308 G/A cg02466173 chr16:30829666 NA -0.63 -6.45 -0.33 3.9e-10 Tonsillectomy; LUSC cis rs2398893 0.960 rs34849895 chr9:96751069 T/C cg14459158 chr9:96720562 NA 0.31 5.87 0.31 1.06e-8 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg15605315 chr1:45957053 TESK2 0.47 7.57 0.38 3.68e-13 High light scatter reticulocyte count; LUSC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg26380479 chr7:97908229 NA -0.28 -6.26 -0.32 1.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.69 0.54 1.07e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1062746 0.520 rs67174101 chr16:87328817 G/A cg02258303 chr16:87377426 FBXO31 -0.53 -7.88 -0.4 4.52e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg05283184 chr6:79620031 NA -0.57 -11.83 -0.54 3.38e-27 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1351164 0.688 rs34587525 chr2:218253689 G/A cg15335768 chr2:218268053 DIRC3 -0.33 -5.88 -0.31 1.01e-8 Height; LUSC cis rs9535307 0.745 rs1407440 chr13:50286218 T/C cg04663916 chr13:50265991 EBPL 0.49 5.71 0.3 2.44e-8 Obesity-related traits; LUSC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.41 0.42 1.18e-15 Tonsillectomy; LUSC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.89 0.51 7.85e-24 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2692947 0.770 rs72823920 chr2:96430876 G/A cg23100626 chr2:96804247 ASTL 0.29 6.86 0.35 3.31e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg26220528 chr12:57623348 SHMT2 0.37 6.39 0.33 5.58e-10 Tuberculosis; LUSC cis rs9818758 0.607 rs12715434 chr3:49295025 G/C cg00383909 chr3:49044727 WDR6 1.15 10.52 0.5 1.54e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC trans rs853679 0.882 rs9380064 chr6:28143118 A/G cg01620082 chr3:125678407 NA -0.59 -6.55 -0.34 2.21e-10 Depression; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02619805 chr19:5623015 SAFB2;SAFB -0.42 -6.27 -0.32 1.14e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.73 0.35 7.39e-11 Intelligence (multi-trait analysis); LUSC trans rs1547374 0.960 rs4920090 chr21:43777897 A/G cg09521743 chr10:75415752 SYNPO2L -0.44 -7.24 -0.37 3.2e-12 Pancreatic cancer; LUSC cis rs34779708 0.966 rs4294520 chr10:35422506 C/T cg04310649 chr10:35416472 CREM -0.43 -6.64 -0.34 1.29e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg11742103 chr11:62369870 EML3;MTA2 0.55 9.04 0.44 1.3e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs870825 0.860 rs72703518 chr4:185602109 T/C cg04058563 chr4:185651563 MLF1IP 0.81 10.68 0.5 4.15e-23 Blood protein levels; LUSC trans rs12579753 0.917 rs4842410 chr12:82219225 A/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.18 -0.32 1.9e-9 Resting heart rate; LUSC cis rs8072100 0.905 rs9895274 chr17:45539117 C/T cg08085267 chr17:45401833 C17orf57 -0.63 -10.63 -0.5 6.32e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504073 0.584 rs60449482 chr8:49974865 G/A cg00325661 chr8:49890786 NA 0.7 11.11 0.52 1.32e-24 Blood metabolite ratios; LUSC cis rs7824557 0.564 rs11782430 chr8:11226071 A/G cg21775007 chr8:11205619 TDH -0.73 -11.4 -0.53 1.21e-25 Retinal vascular caliber; LUSC cis rs231513 0.906 rs11657450 chr17:42002464 C/T cg26893861 chr17:41843967 DUSP3 0.55 5.74 0.3 2.11e-8 Cognitive function; LUSC cis rs6456156 0.565 rs2181058 chr6:167465330 A/T cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs921968 0.643 rs4674305 chr2:219293326 C/T cg02176678 chr2:219576539 TTLL4 0.55 9.51 0.46 3.97e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg00509249 chr6:109615579 CCDC162 -0.33 -5.97 -0.31 5.98e-9 Reticulocyte fraction of red cells; LUSC cis rs360798 0.512 rs17027429 chr2:63079983 C/T cg17519650 chr2:63277830 OTX1 0.48 6.75 0.35 6.5e-11 Coronary artery disease; LUSC cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg24130564 chr14:104152367 KLC1 -0.4 -5.7 -0.3 2.66e-8 Body mass index; LUSC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg06134567 chr22:46658398 PKDREJ -0.53 -6.0 -0.31 5.15e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg08470875 chr2:26401718 FAM59B 0.71 9.86 0.47 2.71e-20 Gut microbiome composition (summer); LUSC cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg16339924 chr4:17578868 LAP3 0.51 7.85 0.39 5.82e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.55 -0.34 2.2e-10 Alzheimer's disease (late onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15740054 chr19:41221099 ADCK4 -0.39 -5.94 -0.31 7.03e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg11941060 chr3:133502564 NA -0.63 -10.22 -0.49 1.62e-21 Iron status biomarkers; LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg24675658 chr1:53192096 ZYG11B -0.69 -11.28 -0.53 3.12e-25 Monocyte count; LUSC cis rs614226 0.935 rs3887875 chr12:120895749 A/G cg21053147 chr12:120880522 NA 0.5 6.08 0.32 3.37e-9 Type 1 diabetes nephropathy; LUSC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 9.42 0.46 7.9e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs8072100 0.967 rs12452315 chr17:45479446 G/T cg03886242 chr7:26192032 NFE2L3 0.36 5.96 0.31 6.58e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2816062 0.786 rs2745317 chr1:18896552 G/A cg18795169 chr1:18902165 NA -1.01 -24.69 -0.8 2.52e-77 Urate levels in lean individuals; LUSC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg09359103 chr1:154839909 KCNN3 -0.74 -17.87 -0.7 1.33e-50 Prostate cancer; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg02018176 chr4:1364513 KIAA1530 -0.46 -8.16 -0.41 7.05e-15 Obesity-related traits; LUSC cis rs7267979 1.000 rs4815424 chr20:25390284 T/C cg08601574 chr20:25228251 PYGB -0.44 -6.78 -0.35 5.45e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8025790 0.508 rs35930676 chr15:67827705 G/A cg24579218 chr15:68104479 NA -0.34 -5.79 -0.3 1.63e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs6547741 0.874 rs58737572 chr2:27852118 A/C cg12559939 chr2:27858050 GPN1 0.4 6.13 0.32 2.52e-9 Oral cavity cancer; LUSC trans rs2587949 0.615 rs2629241 chr3:4208798 A/G cg15139668 chr4:4577005 NA -0.41 -6.03 -0.31 4.44e-9 Periodontitis (DPAL); LUSC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg11494091 chr17:61959527 GH2 0.4 6.91 0.35 2.47e-11 Height; LUSC cis rs34779708 0.931 rs2384289 chr10:35343525 G/A cg04310649 chr10:35416472 CREM -0.41 -6.47 -0.33 3.43e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7824557 0.564 rs2572386 chr8:11236975 A/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.75 -0.3 2.03e-8 Retinal vascular caliber; LUSC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg09877947 chr5:131593287 PDLIM4 -0.39 -6.65 -0.34 1.23e-10 Blood metabolite levels; LUSC cis rs9811920 0.809 rs6806323 chr3:99722564 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -7.14 -0.36 5.79e-12 Axial length; LUSC cis rs9300255 0.568 rs1790102 chr12:123704890 G/A cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC trans rs2243480 1.000 rs34703416 chr7:65300642 A/G cg10756647 chr7:56101905 PSPH 0.87 8.4 0.42 1.31e-15 Diabetic kidney disease; LUSC cis rs4474465 1.000 rs7943673 chr11:78172986 A/G cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.26 0.37 2.75e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7523273 0.606 rs2724382 chr1:207928635 G/C cg22525895 chr1:207977042 MIR29B2 0.4 6.43 0.33 4.3e-10 Schizophrenia; LUSC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.63 0.5 6.24e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -25.14 -0.81 4.96e-79 Height; LUSC cis rs911555 0.617 rs7156036 chr14:103908142 A/G cg12935359 chr14:103987150 CKB 0.66 10.73 0.51 2.73e-23 Intelligence (multi-trait analysis); LUSC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg20476274 chr7:133979776 SLC35B4 0.86 16.01 0.66 3.35e-43 Mean platelet volume; LUSC cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg03713592 chr11:72463424 ARAP1 0.59 7.75 0.39 1.09e-13 Body mass index; LUSC cis rs1018836 0.884 rs2073640 chr8:91594853 A/G cg16814680 chr8:91681699 NA -0.76 -13.13 -0.58 5.03e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg13395646 chr4:1353034 KIAA1530 -0.64 -10.09 -0.48 4.43e-21 Obesity-related traits; LUSC cis rs7267979 1.000 rs6083813 chr20:25337671 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.56 -0.34 2.05e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00543196 chr1:147142741 ACP6 -0.42 -6.1 -0.32 2.93e-9 Electrocardiographic conduction measures; LUSC cis rs6782228 0.606 rs9828893 chr3:128332925 T/C cg16766828 chr3:128327626 NA -0.32 -5.85 -0.3 1.19e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs11971779 0.680 rs4728467 chr7:139120562 G/A cg07862535 chr7:139043722 LUC7L2 0.59 7.16 0.36 5.33e-12 Diisocyanate-induced asthma; LUSC cis rs9341808 0.718 rs2874829 chr6:80856097 A/G cg08355045 chr6:80787529 NA 0.57 9.9 0.48 1.96e-20 Sitting height ratio; LUSC cis rs6840360 0.642 rs7666571 chr4:152443273 C/T cg20465933 chr4:152376761 FAM160A1 0.32 5.84 0.3 1.22e-8 Intelligence (multi-trait analysis); LUSC cis rs12493885 0.818 rs1521324 chr3:153758863 G/T cg17054900 chr3:154042577 DHX36 -0.75 -7.65 -0.39 2.18e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9420 0.961 rs12804972 chr11:57463767 T/C cg23127183 chr11:57508653 C11orf31 -0.58 -9.06 -0.44 1.08e-17 Schizophrenia; LUSC cis rs76878669 0.561 rs4930363 chr11:66169676 C/T cg18002602 chr11:66138449 SLC29A2 0.45 8.16 0.41 6.95e-15 Educational attainment (years of education); LUSC cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg03433033 chr1:76189801 ACADM 0.53 7.42 0.38 9.88e-13 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg14552801 chr7:65878734 NA 0.37 5.85 0.3 1.18e-8 Aortic root size; LUSC cis rs10761482 0.813 rs4948407 chr10:62110199 T/G cg18175470 chr10:62150864 ANK3 -0.5 -7.05 -0.36 1.05e-11 Schizophrenia; LUSC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.85 -0.39 5.74e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs77106637 0.858 rs117819392 chr11:72514503 C/T cg03878208 chr11:72483293 STARD10 0.57 7.28 0.37 2.33e-12 Type 2 diabetes; LUSC cis rs1003719 0.667 rs28666643 chr21:38455999 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 9.49 0.46 4.57e-19 Eye color traits; LUSC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg03806693 chr22:41940476 POLR3H -0.97 -13.08 -0.58 7.85e-32 Vitiligo; LUSC trans rs2243480 1.000 rs6959002 chr7:65650496 A/G cg10756647 chr7:56101905 PSPH -0.84 -8.42 -0.42 1.14e-15 Diabetic kidney disease; LUSC cis rs9283706 0.608 rs10060497 chr5:66332406 A/G cg11590213 chr5:66331682 MAST4 0.47 7.17 0.37 4.71e-12 Coronary artery disease; LUSC trans rs8072100 0.935 rs12150231 chr17:45717091 G/A cg04995722 chr7:26192034 NFE2L3 0.37 6.06 0.31 3.67e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs826838 0.616 rs11182893 chr12:38627715 C/G cg26384229 chr12:38710491 ALG10B -0.57 -8.5 -0.42 6.44e-16 Heart rate; LUSC cis rs12681287 0.604 rs71502657 chr8:87478781 T/A cg27223183 chr8:87520930 FAM82B -0.51 -6.81 -0.35 4.59e-11 Caudate activity during reward; LUSC cis rs17001868 0.568 rs12484697 chr22:40736472 A/G cg07138101 chr22:40742427 ADSL -0.61 -7.32 -0.37 1.87e-12 Mammographic density (dense area); LUSC trans rs1994135 0.715 rs11052742 chr12:33692290 A/C cg13010199 chr12:38710504 ALG10B 0.47 6.56 0.34 2.1e-10 Resting heart rate; LUSC cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1256061 0.603 rs1269056 chr14:64743890 T/C cg23250157 chr14:64679961 SYNE2 0.32 5.71 0.3 2.56e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs6429422 0.725 rs2787232 chr1:243306475 G/C cg01826367 chr1:224180288 NA 0.43 6.36 0.33 6.77e-10 Cognitive ability (multi-trait analysis); LUSC cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 10.0 0.48 9.35e-21 Eosinophil percentage of white cells; LUSC cis rs9329221 0.506 rs17689674 chr8:9981854 C/A cg27411982 chr8:10470053 RP1L1 0.38 5.81 0.3 1.43e-8 Neuroticism; LUSC cis rs4805272 0.512 rs7260055 chr19:29341599 G/A cg04546413 chr19:29218101 NA 0.58 7.23 0.37 3.31e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6496667 0.533 rs2074583 chr15:91009192 T/C cg22089800 chr15:90895588 ZNF774 0.51 7.43 0.38 9.16e-13 Rheumatoid arthritis; LUSC cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs1018836 0.544 rs2063978 chr8:91459525 C/T cg16814680 chr8:91681699 NA -0.48 -6.89 -0.35 2.85e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4423214 0.840 rs1619577 chr11:71181485 C/T cg05163923 chr11:71159392 DHCR7 -0.77 -10.04 -0.48 6.5e-21 Vitamin D levels; LUSC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg23711669 chr6:146136114 FBXO30 0.82 14.54 0.62 1.91e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs7949030 0.653 rs2849030 chr11:62366986 G/A cg13298116 chr11:62369859 EML3;MTA2 -0.58 -9.75 -0.47 6.24e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs1348850 0.958 rs12471741 chr2:178448196 A/G cg22681709 chr2:178499509 PDE11A -0.48 -8.58 -0.43 3.54e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12711979 0.875 rs11686157 chr2:3855020 C/G cg17052675 chr2:3827356 NA -0.45 -8.16 -0.41 6.98e-15 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.37 0.49 4.95e-22 Bladder cancer; LUSC cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg14061069 chr19:46274453 DMPK -0.49 -8.35 -0.42 1.89e-15 Coronary artery disease; LUSC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg22823121 chr1:150693482 HORMAD1 -0.6 -9.43 -0.46 7.2e-19 Tonsillectomy; LUSC cis rs2637266 0.935 rs751770 chr10:78393956 A/G cg18941641 chr10:78392320 NA 0.38 6.74 0.35 7.15e-11 Pulmonary function; LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg15704280 chr7:45808275 SEPT13 0.92 14.5 0.62 2.79e-37 Height; LUSC cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg18681998 chr4:17616180 MED28 -0.76 -13.48 -0.59 2.2e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg11214544 chr1:2391121 NA -0.36 -6.14 -0.32 2.29e-9 Schizophrenia; LUSC cis rs7246967 0.611 rs60021625 chr19:22829554 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs1865721 0.771 rs8093397 chr18:73136217 C/G cg26385618 chr18:73139727 C18orf62 -0.55 -10.1 -0.48 4.25e-21 Intelligence; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23336486 chr4:1341064 KIAA1530 0.39 6.31 0.33 8.62e-10 Asthma; LUSC cis rs62400317 0.762 rs62436376 chr6:44885817 C/T cg18551225 chr6:44695536 NA -0.48 -7.86 -0.4 5.3e-14 Total body bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07336999 chr16:89939803 TCF25 0.41 6.36 0.33 6.65e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg06484146 chr7:12443880 VWDE -0.68 -8.42 -0.42 1.16e-15 Coronary artery disease; LUSC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg00290607 chr11:67383545 NA 0.35 6.59 0.34 1.67e-10 Mean corpuscular volume; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg24675658 chr1:53192096 ZYG11B 0.82 13.93 0.61 4.42e-35 Monocyte count; LUSC trans rs61931739 0.592 rs815042 chr12:33724221 C/A cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.97 -0.51 4.1e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg23985595 chr17:80112537 CCDC57 -0.3 -5.71 -0.3 2.52e-8 Life satisfaction; LUSC cis rs7474896 0.583 rs12783272 chr10:38024885 T/G cg25427524 chr10:38739819 LOC399744 -0.51 -6.47 -0.33 3.52e-10 Obesity (extreme); LUSC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg20891283 chr12:69753455 YEATS4 0.91 17.85 0.7 1.61e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs3768617 0.510 rs6424888 chr1:183085696 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.67 -10.26 -0.49 1.18e-21 Fuchs's corneal dystrophy; LUSC cis rs9916302 0.706 rs2302073 chr17:37457342 A/G cg07936489 chr17:37558343 FBXL20 0.78 9.89 0.48 2.15e-20 Glomerular filtration rate (creatinine); LUSC cis rs644799 0.672 rs11021307 chr11:95501407 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.13 0.58 4.89e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs877282 0.755 rs2486578 chr10:785227 C/T cg13042288 chr15:90349979 ANPEP 0.39 6.1 0.32 2.99e-9 Uric acid levels; LUSC trans rs7726839 0.507 rs56282020 chr5:596701 T/C cg25482853 chr8:67687455 SGK3 1.12 16.14 0.66 1.01e-43 Obesity-related traits; LUSC cis rs11785400 0.793 rs7007891 chr8:143749228 C/T cg24634471 chr8:143751801 JRK -0.5 -7.15 -0.36 5.65e-12 Schizophrenia; LUSC cis rs3768617 0.510 rs4651139 chr1:183091963 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.94 0.51 4.97e-24 Fuchs's corneal dystrophy; LUSC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg10253484 chr15:75165896 SCAMP2 -0.48 -7.36 -0.37 1.42e-12 Breast cancer; LUSC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg08847533 chr14:75593920 NEK9 0.83 14.44 0.62 4.55e-37 Height; LUSC cis rs3741151 0.881 rs10898917 chr11:73065979 G/A cg17517138 chr11:73019481 ARHGEF17 0.89 8.11 0.41 9.44e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9303401 0.614 rs17175663 chr17:57108437 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.84 12.75 0.57 1.34e-30 Cognitive test performance; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg05368731 chr17:41323189 NBR1 0.93 15.69 0.65 5.75e-42 Menopause (age at onset); LUSC cis rs7809950 1.000 rs10267907 chr7:107184466 C/T cg23024343 chr7:107201750 COG5 -0.55 -8.66 -0.43 2.12e-16 Coronary artery disease; LUSC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg13628971 chr7:2884303 GNA12 0.5 6.87 0.35 3.08e-11 Height; LUSC cis rs1113500 0.933 rs10881498 chr1:108634984 C/A cg06207961 chr1:108661230 NA 0.41 7.61 0.38 2.89e-13 Growth-regulated protein alpha levels; LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg03909863 chr11:638404 DRD4 -0.41 -6.19 -0.32 1.81e-9 Systemic lupus erythematosus; LUSC cis rs2985684 0.625 rs4900931 chr14:50022793 A/T cg04989706 chr14:50066350 PPIL5 -0.44 -5.81 -0.3 1.42e-8 Carotid intima media thickness; LUSC cis rs6545883 0.794 rs12053388 chr2:61532320 G/A cg15711740 chr2:61764176 XPO1 0.46 6.99 0.36 1.46e-11 Tuberculosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25445977 chr19:2061242 NA -0.51 -5.98 -0.31 5.81e-9 Bipolar disorder and schizophrenia; LUSC cis rs7582180 0.629 rs4851294 chr2:100941109 C/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.32 -0.41 2.31e-15 Intelligence (multi-trait analysis); LUSC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg02753203 chr1:228287806 NA -0.68 -11.8 -0.54 4.37e-27 Diastolic blood pressure; LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg12442385 chr7:1034912 NA -0.37 -6.38 -0.33 5.88e-10 Longevity;Endometriosis; LUSC cis rs7542375 0.930 rs6680690 chr1:221063684 T/A cg16008148 chr1:221062819 NA 0.37 6.61 0.34 1.49e-10 Obesity-related traits; LUSC cis rs1577917 0.958 rs11758508 chr6:86506878 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.45 6.26 0.32 1.18e-9 Response to antipsychotic treatment; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08089031 chr6:139456240 HECA -0.46 -6.22 -0.32 1.47e-9 Bipolar disorder and schizophrenia; LUSC cis rs7291412 0.540 rs9627391 chr22:46447097 C/T cg23691090 chr22:46449981 C22orf26;LOC150381 0.37 6.45 0.33 3.88e-10 Dupuytren's disease;Subjective well-being; LUSC cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg03146154 chr1:46216737 IPP -0.53 -7.64 -0.39 2.39e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs17401966 0.558 rs12128374 chr1:10426417 G/A cg19773385 chr1:10388646 KIF1B -0.37 -6.41 -0.33 4.88e-10 Hepatocellular carcinoma; LUSC cis rs9911578 0.835 rs723991 chr17:56482039 G/A cg05425664 chr17:57184151 TRIM37 0.55 8.57 0.42 3.81e-16 Intelligence (multi-trait analysis); LUSC cis rs950776 0.752 rs62010328 chr15:78894971 C/T cg06917634 chr15:78832804 PSMA4 0.68 10.78 0.51 1.93e-23 Sudden cardiac arrest; LUSC cis rs4589502 0.502 rs2169460 chr15:67197240 A/G cg12317470 chr15:67143691 NA -0.62 -8.06 -0.4 1.4e-14 Lung cancer (smoking interaction); LUSC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg09165964 chr15:75287851 SCAMP5 0.52 7.59 0.38 3.32e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs12681288 0.676 rs2701927 chr8:995886 G/A cg04851639 chr8:1020857 NA -0.38 -7.76 -0.39 1.02e-13 Schizophrenia; LUSC cis rs8013055 0.846 rs10147392 chr14:105978537 T/G cg19700328 chr14:106028568 NA -0.37 -6.22 -0.32 1.45e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs11190604 1.000 rs17746014 chr10:102315354 T/C cg07080220 chr10:102295463 HIF1AN 0.66 8.51 0.42 5.81e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2295359 0.824 rs12060309 chr1:67604219 T/C cg03340356 chr1:67600835 NA 0.42 6.51 0.34 2.8e-10 Psoriasis; LUSC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg12963246 chr6:28129442 ZNF389 0.4 6.25 0.32 1.27e-9 Parkinson's disease; LUSC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg04455712 chr21:45112962 RRP1B 0.47 8.82 0.43 6.3e-17 Mean corpuscular volume; LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg16325326 chr1:53192061 ZYG11B 0.89 16.36 0.67 1.39e-44 Monocyte count; LUSC cis rs56283067 0.847 rs56172130 chr6:44696262 G/A cg18551225 chr6:44695536 NA -0.48 -8.15 -0.41 7.32e-15 Total body bone mineral density; LUSC trans rs853679 0.517 rs2273564 chr6:28057594 A/T cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.31e-9 Depression; LUSC cis rs1728785 1.000 rs12918861 chr16:68566508 G/A cg02972257 chr16:68554789 NA -0.48 -6.21 -0.32 1.56e-9 Ulcerative colitis; LUSC cis rs9322193 0.567 rs7742692 chr6:150213499 A/G cg09699651 chr6:150184138 LRP11 0.45 7.21 0.37 3.88e-12 Lung cancer; LUSC cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg13319975 chr6:146136371 FBXO30 0.48 7.28 0.37 2.41e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs2262909 0.962 rs2017521 chr19:22126138 T/C cg05197062 chr11:11642011 GALNTL4 -0.51 -7.02 -0.36 1.27e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.3 0.33 9.28e-10 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04246999 chr16:71930048 KIAA0174 -0.43 -6.68 -0.34 1.01e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7119 0.651 rs35577135 chr15:77840074 C/T cg27398640 chr15:77910606 LINGO1 -0.33 -6.66 -0.34 1.15e-10 Type 2 diabetes; LUSC cis rs1801251 1.000 rs11555646 chr2:233599904 A/C cg25237894 chr2:233734115 C2orf82 0.34 6.24 0.32 1.3e-9 Coronary artery disease; LUSC cis rs2857891 0.817 rs1491829 chr11:6968941 T/A cg04053776 chr11:6947353 ZNF215 0.42 5.86 0.31 1.14e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12760731 0.668 rs72482621 chr1:178410442 C/T cg00404053 chr1:178313656 RASAL2 0.59 6.22 0.32 1.46e-9 Obesity-related traits; LUSC cis rs8072100 0.967 rs11656855 chr17:45714655 C/T cg08085267 chr17:45401833 C17orf57 0.55 8.96 0.44 2.32e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg27411982 chr8:10470053 RP1L1 -0.46 -7.16 -0.36 5.17e-12 Monocyte count; LUSC cis rs7809950 1.000 rs2395883 chr7:107089670 T/C cg23024343 chr7:107201750 COG5 -0.56 -8.85 -0.44 5.32e-17 Coronary artery disease; LUSC cis rs68170813 0.559 rs2189501 chr7:106942766 A/T cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.64 -0.3 3.56e-8 Coronary artery disease; LUSC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg08847533 chr14:75593920 NEK9 -0.82 -15.13 -0.64 9.25e-40 Height; LUSC cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs10754283 0.967 rs7513928 chr1:90104834 A/G cg21401794 chr1:90099060 LRRC8C 0.66 9.93 0.48 1.55e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg06718696 chr17:78121285 EIF4A3 -0.79 -11.69 -0.54 1.09e-26 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC cis rs9549260 0.755 rs2721069 chr13:41143720 C/T cg21288729 chr13:41239152 FOXO1 0.58 8.69 0.43 1.62e-16 Red blood cell count; LUSC cis rs8078723 0.510 rs9898547 chr17:38136026 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.58 9.9 0.48 1.97e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs870825 0.616 rs6810635 chr4:185616859 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.4 0.59 4.75e-33 Blood protein levels; LUSC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg27494647 chr7:150038898 RARRES2 0.49 7.42 0.38 1.01e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs834811 0.829 rs834818 chr7:135895070 A/G cg01726295 chr7:135938950 NA 0.41 7.17 0.37 4.72e-12 Post-traumatic stress disorder; LUSC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08704250 chr15:31115839 NA -0.47 -7.09 -0.36 8.12e-12 Huntington's disease progression; LUSC trans rs2243480 1.000 rs1979823 chr7:65704613 G/A cg10756647 chr7:56101905 PSPH -0.87 -8.68 -0.43 1.81e-16 Diabetic kidney disease; LUSC cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg15744005 chr10:104629667 AS3MT -0.27 -5.71 -0.3 2.44e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg00071950 chr4:10020882 SLC2A9 -0.53 -8.08 -0.4 1.17e-14 Bone mineral density; LUSC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg01616529 chr11:638424 DRD4 -0.33 -5.73 -0.3 2.3e-8 Systemic lupus erythematosus; LUSC cis rs763121 0.853 rs5750621 chr22:38956166 C/T cg06022373 chr22:39101656 GTPBP1 0.77 11.77 0.54 5.6e-27 Menopause (age at onset); LUSC cis rs6594499 0.843 rs1993465 chr5:110433098 A/G cg04022379 chr5:110408740 TSLP 0.45 6.78 0.35 5.51e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs250677 0.522 rs1007400 chr5:148382635 C/T cg18129178 chr5:148520854 ABLIM3 0.49 7.25 0.37 2.97e-12 Breast cancer; LUSC cis rs62400317 0.826 rs12213735 chr6:45152848 C/T cg18551225 chr6:44695536 NA 0.42 6.96 0.36 1.83e-11 Total body bone mineral density; LUSC trans rs3733585 0.673 rs4292333 chr4:9953871 G/A cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6964587 1.000 rs1859037 chr7:91568272 A/G cg01689657 chr7:91764605 CYP51A1 -0.34 -6.02 -0.31 4.56e-9 Breast cancer; LUSC cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs2282300 0.739 rs34224414 chr11:30251041 T/G cg25418670 chr11:30344373 C11orf46 -0.66 -9.53 -0.46 3.4e-19 Morning vs. evening chronotype; LUSC cis rs9326248 0.520 rs1446105 chr11:116798544 C/T cg01368799 chr11:117014884 PAFAH1B2 0.58 8.85 0.44 5.08e-17 Blood protein levels; LUSC trans rs11671005 0.610 rs4756 chr19:59074653 T/C cg22037779 chr5:139682734 PFDN1 -0.57 -7.4 -0.38 1.08e-12 Mean platelet volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11192808 chr8:101170185 SPAG1 -0.49 -6.39 -0.33 5.67e-10 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09746031 chr17:40336180 HCRT 0.43 6.34 0.33 7.29e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg01475377 chr6:109611718 NA -0.37 -6.55 -0.34 2.22e-10 Reticulocyte fraction of red cells; LUSC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg00310523 chr12:86230176 RASSF9 0.44 7.91 0.4 3.74e-14 Major depressive disorder; LUSC cis rs668210 0.793 rs507672 chr11:65767153 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 -0.58 -7.72 -0.39 1.34e-13 Cerebrospinal fluid biomarker levels; LUSC trans rs7824557 0.872 rs2572417 chr8:11111462 A/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.91 -0.4 3.82e-14 Retinal vascular caliber; LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02018176 chr4:1364513 KIAA1530 0.72 13.96 0.61 3.36e-35 Longevity; LUSC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg11812906 chr14:75593930 NEK9 -0.65 -11.23 -0.52 4.73e-25 Height; LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg10802521 chr3:52805072 NEK4 -0.56 -8.78 -0.43 8.37e-17 Bipolar disorder; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg27284194 chr4:1044797 NA 0.35 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs9650657 0.644 rs7012206 chr8:10697015 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.32 -0.33 8.37e-10 Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20477929 chr11:70116563 PPFIA1 -0.44 -6.68 -0.34 1.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4619890 0.528 rs28417050 chr4:7883077 T/C cg24250820 chr4:7887609 AFAP1 0.36 6.19 0.32 1.73e-9 Glaucoma (primary open-angle); LUSC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg24531977 chr5:56204891 C5orf35 -0.83 -12.98 -0.58 1.72e-31 Coronary artery disease; LUSC cis rs8060686 0.623 rs7201591 chr16:68086105 A/G cg05110241 chr16:68378359 PRMT7 -0.46 -6.12 -0.32 2.59e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg26384229 chr12:38710491 ALG10B 0.94 17.96 0.7 5.88e-51 Heart rate; LUSC cis rs4604732 0.631 rs12080860 chr1:247623053 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.69 0.34 9.48e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs4629710 0.592 rs10484763 chr6:131549060 T/C cg12700074 chr6:131571435 AKAP7 -0.37 -6.11 -0.32 2.84e-9 Multiple myeloma (IgH translocation); LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg08472276 chr7:1133186 C7orf50;GPER -0.34 -5.79 -0.3 1.62e-8 Longevity;Endometriosis; LUSC cis rs4343996 0.934 rs6959232 chr7:3376530 A/G cg21248987 chr7:3385318 SDK1 -0.4 -6.8 -0.35 4.75e-11 Motion sickness; LUSC cis rs561341 0.739 rs1978116 chr17:30220978 A/C cg00745463 chr17:30367425 LRRC37B -0.56 -7.16 -0.36 5.04e-12 Hip circumference adjusted for BMI; LUSC cis rs12893668 0.638 rs11851616 chr14:104065600 G/A cg08213375 chr14:104286397 PPP1R13B 0.4 6.94 0.35 2.08e-11 Reticulocyte count; LUSC cis rs2000999 0.515 rs2854956 chr16:72115238 A/T cg01557791 chr16:72042693 DHODH -0.54 -7.84 -0.39 6.29e-14 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; LUSC cis rs807669 0.548 rs9605957 chr22:19187375 G/A cg02655711 chr22:19163373 SLC25A1 0.54 9.91 0.48 1.78e-20 Metabolite levels; LUSC cis rs4363385 0.667 rs11803197 chr1:152934420 G/A cg00922841 chr1:152955080 SPRR1A -0.38 -6.09 -0.32 3.1e-9 Inflammatory skin disease; LUSC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg21724239 chr8:58056113 NA 0.69 7.53 0.38 4.92e-13 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.76 0.35 6.26e-11 Obesity-related traits; LUSC cis rs7772486 0.875 rs1960885 chr6:146325930 G/T cg23711669 chr6:146136114 FBXO30 0.84 15.12 0.64 9.9e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 0.572 rs11559183 chr7:1037025 C/A cg24642844 chr7:1081250 C7orf50 -0.71 -6.69 -0.34 9.41e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg12516959 chr21:47718080 NA -0.39 -6.32 -0.33 8.37e-10 Testicular germ cell tumor; LUSC cis rs1997103 1.000 rs4948011 chr7:55403859 A/G cg17469321 chr7:55412551 NA 0.62 10.13 0.48 3.24e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10782582 0.532 rs78106188 chr1:76137836 A/G cg03433033 chr1:76189801 ACADM -0.46 -6.97 -0.36 1.73e-11 Daytime sleep phenotypes; LUSC cis rs7315438 0.600 rs7962892 chr12:115877766 T/A cg24172291 chr12:115889509 NA -0.35 -5.96 -0.31 6.3e-9 Colorectal cancer; LUSC cis rs921968 0.540 rs6746040 chr2:219588890 G/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.19 -0.49 2.02e-21 Mean corpuscular hemoglobin concentration; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15235185 chr1:193028809 TROVE2;UCHL5 0.41 6.04 0.31 4.04e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs7618501 0.633 rs2353579 chr3:50027774 C/T cg21659725 chr3:3221576 CRBN 0.63 10.24 0.49 1.43e-21 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.8 0.39 7.87e-14 Gut microbiome composition (summer); LUSC cis rs8141529 0.636 rs5762799 chr22:29187380 G/T cg02153584 chr22:29168773 CCDC117 0.5 6.53 0.34 2.45e-10 Lymphocyte counts; LUSC cis rs4820539 0.708 rs5751591 chr22:23489042 G/A cg14186256 chr22:23484241 RTDR1 0.73 11.49 0.53 5.69e-26 Bone mineral density; LUSC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg07936489 chr17:37558343 FBXL20 0.72 10.11 0.48 3.74e-21 Glomerular filtration rate (creatinine); LUSC cis rs453301 0.631 rs28572014 chr8:8793607 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.7 -0.39 1.53e-13 Joint mobility (Beighton score); LUSC cis rs2880765 0.835 rs11074276 chr15:86030363 C/A cg13263323 chr15:86062960 AKAP13 -0.35 -5.72 -0.3 2.38e-8 Coronary artery disease; LUSC cis rs7119 0.679 rs34075648 chr15:77847802 G/C cg27398640 chr15:77910606 LINGO1 -0.33 -7.04 -0.36 1.12e-11 Type 2 diabetes; LUSC cis rs8038465 0.622 rs17185525 chr15:73885539 T/C cg15420318 chr15:73925796 NPTN 0.55 9.31 0.45 1.8e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg26384229 chr12:38710491 ALG10B 0.86 14.38 0.62 7.74e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg18876405 chr7:65276391 NA -0.56 -8.93 -0.44 2.86e-17 Aortic root size; LUSC cis rs79387448 0.745 rs6709719 chr2:103144953 G/A cg09003973 chr2:102972529 NA 0.89 8.68 0.43 1.76e-16 Gut microbiota (bacterial taxa); LUSC cis rs4665630 0.522 rs75866363 chr2:24046426 G/A cg08063864 chr2:24346004 PFN4;LOC375190 0.94 8.03 0.4 1.74e-14 Hypertension; LUSC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg24531977 chr5:56204891 C5orf35 -0.78 -11.46 -0.53 7.52e-26 Type 2 diabetes; LUSC cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.58 -11.12 -0.52 1.17e-24 Monocyte percentage of white cells; LUSC cis rs887829 0.570 rs11680450 chr2:234597483 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.28 -0.33 1.04e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 3.96e-12 Motion sickness; LUSC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.46 0.59 2.79e-33 Platelet count; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg11060661 chr22:24314208 DDT;DDTL -0.48 -7.81 -0.39 7.47e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2479724 0.805 rs11756454 chr6:41798578 T/A cg17623882 chr6:41773611 USP49 0.65 10.61 0.5 7.42e-23 Menarche (age at onset); LUSC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg05855489 chr10:104503620 C10orf26 0.6 8.7 0.43 1.55e-16 Arsenic metabolism; LUSC trans rs1814175 0.645 rs28549248 chr11:50042740 C/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg23788917 chr6:8435910 SLC35B3 0.51 7.58 0.38 3.38e-13 Motion sickness; LUSC cis rs12425451 0.544 rs3741951 chr12:3147080 A/G cg05389053 chr12:3131226 TEAD4 0.43 5.75 0.3 1.96e-8 Narcolepsy with cataplexy; LUSC cis rs9300255 0.739 rs1402275 chr12:123750895 A/G cg00376283 chr12:123451042 ABCB9 0.68 8.44 0.42 1.01e-15 Neutrophil percentage of white cells; LUSC cis rs9916302 0.706 rs4795375 chr17:37662932 T/C cg07936489 chr17:37558343 FBXL20 -0.82 -9.8 -0.47 4.44e-20 Glomerular filtration rate (creatinine); LUSC cis rs25645 0.760 rs11870683 chr17:38129841 T/A cg17344932 chr17:38183730 MED24;SNORD124 0.65 11.09 0.52 1.47e-24 Myeloid white cell count; LUSC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg06238570 chr21:40685208 BRWD1 0.47 7.27 0.37 2.56e-12 Cognitive function; LUSC cis rs16976116 0.951 rs12385963 chr15:55482851 A/G cg11288833 chr15:55489084 RSL24D1 0.53 6.35 0.33 7.21e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg21856205 chr7:94953877 PON1 -0.36 -5.77 -0.3 1.77e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg21141812 chr3:48556323 PFKFB4 0.33 5.68 0.3 2.96e-8 Menarche (age at onset); LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg26304593 chr6:42947056 PEX6 -0.54 -8.39 -0.42 1.35e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg24130564 chr14:104152367 KLC1 -0.39 -5.69 -0.3 2.71e-8 Body mass index; LUSC cis rs56283067 0.578 rs12201563 chr6:45359394 T/C cg18551225 chr6:44695536 NA -0.44 -6.58 -0.34 1.86e-10 Total body bone mineral density; LUSC cis rs9486719 1.000 rs35487471 chr6:96879715 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs9640161 0.830 rs12703061 chr7:150062545 T/C cg10018233 chr7:150070692 REPIN1 0.39 7.08 0.36 8.46e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs752010 0.530 rs10789401 chr1:42081111 A/G cg06885757 chr1:42089581 HIVEP3 0.63 13.32 0.59 9.24e-33 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs4862307 0.836 rs6829678 chr4:185001631 C/T cg06737308 chr4:185021514 ENPP6 -0.46 -7.14 -0.36 5.87e-12 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs733592 0.507 rs3825403 chr12:48457159 G/A cg24011408 chr12:48396354 COL2A1 -0.53 -8.72 -0.43 1.34e-16 Plateletcrit; LUSC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg00944433 chr1:107599041 PRMT6 -0.38 -6.97 -0.36 1.69e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9611565 1.000 rs1109151 chr22:41752944 A/G cg03806693 chr22:41940476 POLR3H -0.75 -10.71 -0.51 3.31e-23 Vitiligo; LUSC cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg06026331 chr20:60912101 LAMA5 0.58 6.9 0.35 2.65e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg13685833 chr1:53393034 SCP2 0.39 5.93 0.31 7.74e-9 Monocyte count; LUSC cis rs9300255 0.679 rs58809476 chr12:123724880 C/T cg13010344 chr12:123464640 ARL6IP4 0.47 5.85 0.3 1.18e-8 Neutrophil percentage of white cells; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg10862848 chr6:42927986 GNMT -0.29 -7.04 -0.36 1.08e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg19901468 chr14:105411992 AHNAK2 -0.7 -12.14 -0.55 2.36e-28 Rheumatoid arthritis; LUSC cis rs7267979 1.000 rs401166 chr20:25446308 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg23172400 chr8:95962367 TP53INP1 -0.4 -8.42 -0.42 1.12e-15 Type 2 diabetes; LUSC cis rs1577917 1.000 rs1962716 chr6:86648436 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.7 -0.34 8.66e-11 Response to antipsychotic treatment; LUSC cis rs7267979 0.966 rs2482923 chr20:25308981 T/C cg03522245 chr20:25566470 NINL -0.36 -5.88 -0.31 1.02e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg13628971 chr7:2884303 GNA12 0.47 6.64 0.34 1.27e-10 Height; LUSC cis rs17270561 1.000 rs79867288 chr6:25828416 A/G cg16482183 chr6:26056742 HIST1H1C 0.78 9.84 0.47 3.11e-20 Iron status biomarkers; LUSC trans rs10090774 0.965 rs13264974 chr8:141918720 C/A cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 5.96 0.31 6.36e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25878452 chr7:6746558 ZNF12 -0.47 -6.95 -0.36 1.91e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2901656 0.677 rs2301455 chr1:172418268 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.35 7.03 0.36 1.15e-11 Red cell distribution width;Platelet distribution width; LUSC cis rs2273669 0.585 rs6900472 chr6:109372120 G/A cg05315195 chr6:109294784 ARMC2 -0.51 -5.71 -0.3 2.53e-8 Prostate cancer; LUSC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg14668632 chr7:2872130 GNA12 -0.43 -6.01 -0.31 4.78e-9 Height; LUSC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.61 9.29 0.45 2.02e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg15534755 chr11:117069859 TAGLN 0.36 6.3 0.33 9.54e-10 Blood protein levels; LUSC cis rs10821973 0.558 rs6479799 chr10:64023166 A/G cg19640130 chr10:64028056 RTKN2 -0.39 -6.31 -0.33 8.72e-10 Hypothyroidism; LUSC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg11663144 chr21:46675770 NA -0.41 -7.09 -0.36 7.96e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg04398451 chr17:18023971 MYO15A -0.46 -7.29 -0.37 2.3e-12 Total body bone mineral density; LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.18 0.37 4.54e-12 Bipolar disorder; LUSC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg06453172 chr10:134556979 INPP5A -0.49 -6.11 -0.32 2.78e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs57046232 0.552 rs4402836 chr20:6338026 G/A cg21095983 chr6:86352623 SYNCRIP 0.46 6.91 0.35 2.45e-11 Colorectal cancer; LUSC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg20243544 chr17:37824526 PNMT 0.38 5.78 0.3 1.7e-8 Self-reported allergy; LUSC cis rs748404 0.697 rs1095389 chr15:43566671 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.44 6.23 0.32 1.43e-9 Lung cancer; LUSC cis rs8062405 0.755 rs4788074 chr16:28593597 A/G cg07382826 chr16:28625726 SULT1A1 -0.28 -6.08 -0.32 3.29e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11098499 0.863 rs11947234 chr4:120474859 A/G cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg27129171 chr3:47204927 SETD2 -0.7 -11.7 -0.54 1.02e-26 Colorectal cancer; LUSC trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg15704280 chr7:45808275 SEPT13 -1.11 -22.0 -0.77 6.18e-67 Height; LUSC cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.39 -5.73 -0.3 2.23e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06395280 chr2:242295608 FARP2 -0.42 -6.2 -0.32 1.65e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.05 20.0 0.74 4.7e-59 Cognitive ability; LUSC cis rs907683 0.570 rs2666104 chr2:220281010 C/T cg15015639 chr2:220282977 DES -0.31 -7.05 -0.36 1.03e-11 Resting heart rate; LUSC cis rs9300255 0.602 rs1790095 chr12:123681222 G/A cg05973401 chr12:123451056 ABCB9 0.52 6.46 0.33 3.79e-10 Neutrophil percentage of white cells; LUSC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg18876405 chr7:65276391 NA 0.55 5.87 0.31 1.06e-8 Diabetic kidney disease; LUSC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg06636001 chr8:8085503 FLJ10661 0.65 10.52 0.5 1.58e-22 Mood instability; LUSC cis rs2302777 0.507 rs9889711 chr17:38108292 A/T cg26162295 chr17:38119207 GSDMA -0.28 -6.33 -0.33 8.07e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg23758822 chr17:41437982 NA 1.05 20.23 0.74 5.91e-60 Menopause (age at onset); LUSC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg19717773 chr7:2847554 GNA12 -0.37 -6.05 -0.31 3.98e-9 Height; LUSC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg20203395 chr5:56204925 C5orf35 -0.72 -9.94 -0.48 1.41e-20 Initial pursuit acceleration; LUSC cis rs2294693 0.786 rs10456497 chr6:40989057 T/C cg14769373 chr6:40998127 UNC5CL -0.57 -7.32 -0.37 1.86e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg09455208 chr3:40491958 NA 0.58 10.15 0.49 2.74e-21 Renal cell carcinoma; LUSC cis rs977987 0.836 rs7199062 chr16:75474827 G/A cg04384234 chr16:75411784 CFDP1 -0.45 -7.5 -0.38 5.93e-13 Dupuytren's disease; LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg16405210 chr4:1374714 KIAA1530 0.78 12.42 0.56 2.27e-29 Longevity; LUSC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg15468180 chr1:107600409 PRMT6 -0.36 -5.83 -0.3 1.31e-8 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg11742103 chr11:62369870 EML3;MTA2 0.48 7.36 0.37 1.45e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg08847533 chr14:75593920 NEK9 0.86 16.21 0.66 5.23e-44 Height; LUSC cis rs28595532 0.748 rs67928655 chr4:119336525 C/A cg21605333 chr4:119757512 SEC24D 0.97 8.07 0.4 1.26e-14 Cannabis dependence symptom count; LUSC trans rs7824557 0.603 rs2250028 chr8:11213589 T/G cg15556689 chr8:8085844 FLJ10661 0.57 8.34 0.42 1.98e-15 Retinal vascular caliber; LUSC trans rs1814175 0.781 rs1851872 chr11:50009770 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg01849466 chr14:104193079 ZFYVE21 -0.55 -7.88 -0.4 4.53e-14 Reticulocyte count; LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg04944784 chr2:26401820 FAM59B 0.77 11.41 0.53 1.12e-25 Gut microbiome composition (summer); LUSC cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.47 6.7 0.34 8.83e-11 Monocyte percentage of white cells; LUSC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg23985595 chr17:80112537 CCDC57 -0.31 -5.94 -0.31 7.02e-9 Life satisfaction; LUSC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg21573476 chr21:45109991 RRP1B -0.36 -6.04 -0.31 4.04e-9 Mean corpuscular volume; LUSC cis rs7215564 0.818 rs35459747 chr17:78661475 T/C cg23238734 chr17:78661607 RPTOR 0.47 6.09 0.32 3.13e-9 Myopia (pathological); LUSC cis rs7954584 0.626 rs10840637 chr12:122427310 A/G cg21016266 chr12:122356598 WDR66 0.57 8.48 0.42 7.25e-16 Mean corpuscular volume; LUSC cis rs9905704 0.918 rs12949138 chr17:56934865 A/C cg12560992 chr17:57184187 TRIM37 0.54 7.75 0.39 1.15e-13 Testicular germ cell tumor; LUSC cis rs9303401 0.659 rs9303399 chr17:56672309 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.85 13.09 0.58 7.12e-32 Cognitive test performance; LUSC cis rs7824557 0.628 rs7008205 chr8:11197323 T/G cg21775007 chr8:11205619 TDH 0.81 13.85 0.6 8.77e-35 Retinal vascular caliber; LUSC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg12751644 chr20:60527061 NA -0.33 -5.91 -0.31 8.33e-9 Body mass index; LUSC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg24399712 chr22:39784796 NA -0.63 -10.47 -0.5 2.18e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs8060686 0.641 rs2107369 chr16:68116018 A/C cg26727032 chr16:67993705 SLC12A4 -0.44 -6.2 -0.32 1.65e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg03676636 chr4:99064102 C4orf37 0.38 8.0 0.4 2.02e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 8.01e-25 Mean corpuscular volume; LUSC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -14.06 -0.61 1.38e-35 Extrinsic epigenetic age acceleration; LUSC cis rs3744061 0.557 rs2098091 chr17:74646817 A/G cg27546012 chr17:74684504 MXRA7 -0.37 -6.37 -0.33 6.19e-10 Retinal arteriolar caliber; LUSC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg22800045 chr5:56110881 MAP3K1 -0.48 -6.35 -0.33 7.05e-10 Coronary artery disease; LUSC cis rs3771570 1.000 rs73004382 chr2:242382192 C/T cg21155796 chr2:242212141 HDLBP 0.6 6.54 0.34 2.28e-10 Prostate cancer; LUSC trans rs2243480 0.803 rs423187 chr7:65509499 G/C cg10756647 chr7:56101905 PSPH 0.87 8.5 0.42 6.62e-16 Diabetic kidney disease; LUSC cis rs3796619 0.924 rs11940546 chr4:1072485 C/T cg27284194 chr4:1044797 NA 0.51 8.48 0.42 7.14e-16 Recombination rate (males); LUSC cis rs9457247 0.508 rs9457268 chr6:167503639 A/T cg07741184 chr6:167504864 NA 0.39 6.9 0.35 2.56e-11 Crohn's disease; LUSC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg17143192 chr8:8559678 CLDN23 0.66 9.26 0.45 2.46e-18 Obesity-related traits; LUSC cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.19 -0.32 1.79e-9 IgG glycosylation; LUSC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg06636001 chr8:8085503 FLJ10661 -0.64 -9.96 -0.48 1.24e-20 Mood instability; LUSC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg04287289 chr16:89883240 FANCA -0.72 -10.77 -0.51 2.11e-23 Vitiligo; LUSC cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg06784218 chr1:46089804 CCDC17 -0.57 -11.28 -0.53 3.09e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.47 7.17 0.37 4.86e-12 Cognitive test performance; LUSC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.64 8.05 0.4 1.45e-14 Lung function (FEV1/FVC); LUSC cis rs4820294 0.669 rs732857 chr22:38060850 C/T cg21798802 chr22:38057573 PDXP 0.34 7.17 0.37 4.89e-12 Fat distribution (HIV); LUSC trans rs28735056 0.563 rs12968139 chr18:77685520 A/G cg05926928 chr17:57297772 GDPD1 -0.46 -6.46 -0.33 3.76e-10 Schizophrenia; LUSC cis rs77633900 0.614 rs203753 chr15:76946195 A/T cg21673338 chr15:77095150 SCAPER -0.74 -7.39 -0.37 1.19e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs1670533 1.000 rs6852155 chr4:1067638 T/G cg27284194 chr4:1044797 NA 0.6 9.01 0.44 1.62e-17 Recombination rate (females); LUSC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg01191920 chr7:158217561 PTPRN2 -0.51 -10.71 -0.51 3.3e-23 Obesity-related traits; LUSC cis rs11122272 0.735 rs2808584 chr1:231512925 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20541753 chr11:34938014 PDHX;APIP -0.45 -6.75 -0.35 6.43e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg21211367 chr2:162094118 NA 0.44 7.13 0.36 6.38e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg24829409 chr8:58192753 C8orf71 0.54 6.01 0.31 4.95e-9 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs500891 0.553 rs9449623 chr6:84180355 A/T cg08257003 chr6:84140564 ME1 -0.32 -7.79 -0.39 8.71e-14 Platelet-derived growth factor BB levels; LUSC trans rs7937682 0.632 rs11214009 chr11:111683142 T/C cg18187862 chr3:45730750 SACM1L -0.52 -6.33 -0.33 7.7e-10 Primary sclerosing cholangitis; LUSC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg11344533 chr11:111475393 SIK2 -0.49 -6.89 -0.35 2.86e-11 Primary sclerosing cholangitis; LUSC cis rs11098499 0.955 rs6815725 chr4:120158410 C/A cg09307838 chr4:120376055 NA 0.7 10.17 0.49 2.4e-21 Corneal astigmatism; LUSC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg07424592 chr7:64974309 NA 0.66 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg22823121 chr1:150693482 HORMAD1 0.5 7.24 0.37 3.11e-12 Melanoma; LUSC cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg16339924 chr4:17578868 LAP3 0.55 8.37 0.42 1.57e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6700896 0.931 rs4655585 chr1:66155627 T/C cg04111102 chr1:66153794 NA 0.33 7.4 0.38 1.14e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2860975 1.000 rs7899746 chr10:96787859 T/C cg09036531 chr10:96991505 NA -0.42 -5.71 -0.3 2.46e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs9486719 1.000 rs4262195 chr6:96929475 T/C cg06623918 chr6:96969491 KIAA0776 -0.82 -10.0 -0.48 9.04e-21 Migraine;Coronary artery disease; LUSC trans rs11039798 0.588 rs3924476 chr11:48581733 T/C cg03929089 chr4:120376271 NA 0.58 6.49 0.33 3.04e-10 Axial length; LUSC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg17986701 chr20:44574422 PCIF1 0.37 6.64 0.34 1.26e-10 Intelligence (multi-trait analysis); LUSC cis rs9650657 0.655 rs4841434 chr8:10586123 T/C cg14992524 chr8:10586135 SOX7 -0.33 -5.94 -0.31 7.03e-9 Neuroticism; LUSC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg17986701 chr20:44574422 PCIF1 0.4 7.12 0.36 6.79e-12 Intelligence (multi-trait analysis); LUSC cis rs9648716 0.515 rs38730 chr7:140704638 C/T cg23214464 chr7:140373596 ADCK2 0.72 6.24 0.32 1.34e-9 Type 2 diabetes; LUSC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg15664640 chr17:80829946 TBCD -0.72 -12.55 -0.57 7.43e-30 Breast cancer; LUSC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg23630131 chr7:65973040 NA 0.21 5.78 0.3 1.74e-8 Aortic root size; LUSC cis rs611744 0.647 rs2597658 chr8:109256014 C/T cg18478394 chr8:109455254 TTC35 0.42 6.41 0.33 5.04e-10 Dupuytren's disease; LUSC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg26513180 chr16:89883248 FANCA 0.92 17.48 0.69 4.71e-49 Vitiligo; LUSC trans rs6480314 0.542 rs17297383 chr10:70028863 C/T cg04882175 chr6:131122610 NA -0.54 -6.26 -0.32 1.18e-9 Optic nerve measurement (disc area); LUSC cis rs9790314 0.521 rs60625846 chr3:161084525 G/T cg03342759 chr3:160939853 NMD3 -0.41 -5.98 -0.31 5.71e-9 Morning vs. evening chronotype; LUSC cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg08807101 chr21:30365312 RNF160 0.79 14.92 0.63 6.05e-39 Dental caries; LUSC cis rs7827545 0.545 rs1867062 chr8:135559079 G/A cg17885191 chr8:135476712 NA 0.62 7.91 0.4 3.76e-14 Hypertension (SNP x SNP interaction); LUSC cis rs6496044 0.568 rs12708554 chr15:86074297 C/G cg13263323 chr15:86062960 AKAP13 -0.35 -5.73 -0.3 2.25e-8 Interstitial lung disease; LUSC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg23590916 chr17:43697445 MGC57346 -0.49 -6.59 -0.34 1.7e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9325144 0.647 rs11168819 chr12:39011082 C/A cg26384229 chr12:38710491 ALG10B -0.64 -9.95 -0.48 1.37e-20 Morning vs. evening chronotype; LUSC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg24549020 chr5:56110836 MAP3K1 0.48 5.71 0.3 2.46e-8 Initial pursuit acceleration; LUSC cis rs1957429 0.614 rs73279823 chr14:65351315 A/G cg23373153 chr14:65346875 NA -0.99 -8.98 -0.44 1.97e-17 Pediatric areal bone mineral density (radius); LUSC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg03433033 chr1:76189801 ACADM -0.65 -8.92 -0.44 3.2e-17 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs724744 0.935 rs707871 chr6:22335048 T/C cg13807341 chr11:118445984 ARCN1 -0.35 -6.02 -0.31 4.72e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.78 7.41 0.38 1.08e-12 Cerebrospinal P-tau181p levels; LUSC cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg05855489 chr10:104503620 C10orf26 0.52 8.0 0.4 2.13e-14 Arsenic metabolism; LUSC cis rs2439831 1.000 rs690263 chr15:43704465 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.73 0.43 1.22e-16 Lung cancer in ever smokers; LUSC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg22875332 chr1:76189707 ACADM 0.85 15.67 0.65 6.91e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg18252515 chr7:66147081 NA -1.23 -14.09 -0.61 1.07e-35 Diabetic kidney disease; LUSC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg19257562 chr1:2043853 PRKCZ 0.31 6.25 0.32 1.23e-9 Height; LUSC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg22535103 chr8:58192502 C8orf71 -0.73 -7.44 -0.38 8.49e-13 Developmental language disorder (linguistic errors); LUSC cis rs3847687 1.000 rs3847688 chr12:131525310 C/T cg25772418 chr12:131519998 GPR133 -0.26 -5.74 -0.3 2.11e-8 Longevity; LUSC cis rs1670533 1.000 rs10031302 chr4:1059664 G/A cg27284194 chr4:1044797 NA 0.59 8.7 0.43 1.49e-16 Recombination rate (females); LUSC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg18904891 chr8:8559673 CLDN23 0.56 7.8 0.39 7.89e-14 Obesity-related traits; LUSC cis rs12579753 1.000 rs12580330 chr12:82241280 T/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs7578035 0.500 rs17021941 chr2:99384299 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.29 -0.33 9.72e-10 Bipolar disorder; LUSC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg18350739 chr11:68623251 NA -0.37 -6.36 -0.33 6.73e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC trans rs2229238 0.911 rs6674171 chr1:154491683 A/G cg25273160 chr11:56955011 LRRC55 0.31 5.96 0.31 6.37e-9 Coronary heart disease; LUSC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg22875332 chr1:76189707 ACADM 0.85 13.81 0.6 1.22e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg11344533 chr11:111475393 SIK2 -0.47 -6.31 -0.33 8.66e-10 Primary sclerosing cholangitis; LUSC cis rs6961069 0.745 rs1953298 chr7:80265451 C/T cg04458919 chr7:80252533 CD36 -0.37 -6.69 -0.34 9.65e-11 Platelet count; LUSC cis rs9399135 0.967 rs1014020 chr6:135334426 C/A cg24558204 chr6:135376177 HBS1L 0.59 9.12 0.45 7.4e-18 Red blood cell count; LUSC cis rs9325144 0.510 rs6582599 chr12:38715965 T/G cg26384229 chr12:38710491 ALG10B 0.6 9.35 0.46 1.34e-18 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.91 -13.29 -0.59 1.22e-32 Alzheimer's disease; LUSC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg04455712 chr21:45112962 RRP1B 0.49 9.23 0.45 3.25e-18 Mean corpuscular volume; LUSC cis rs2274273 0.588 rs11158037 chr14:55832152 C/A cg04306507 chr14:55594613 LGALS3 0.49 9.82 0.47 3.79e-20 Protein biomarker; LUSC cis rs1784581 0.588 rs1784606 chr6:162405992 A/T cg17173639 chr6:162384350 PARK2 -0.54 -9.26 -0.45 2.55e-18 Itch intensity from mosquito bite; LUSC cis rs2455601 0.671 rs2568091 chr11:8986048 C/A cg09997546 chr11:8931473 C11orf17;ST5 -0.43 -7.09 -0.36 8.27e-12 Schizophrenia; LUSC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg08975724 chr8:8085496 FLJ10661 0.59 8.85 0.44 5.37e-17 Systolic blood pressure; LUSC cis rs367943 0.712 rs7714734 chr5:112691261 G/A cg12552261 chr5:112820674 MCC 0.41 6.69 0.34 9.64e-11 Type 2 diabetes; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg09877947 chr5:131593287 PDLIM4 0.49 8.45 0.42 9.13e-16 Blood metabolite levels; LUSC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg16423285 chr20:60520624 NA -0.46 -5.76 -0.3 1.94e-8 Body mass index; LUSC cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg20701182 chr2:24300061 SF3B14 0.89 11.69 0.54 1.08e-26 Lymphocyte counts; LUSC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 3.03e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.36 -5.86 -0.31 1.11e-8 Alzheimer's disease (late onset); LUSC cis rs11051970 0.879 rs2651378 chr12:32581794 A/G cg02745156 chr12:32552066 NA 0.43 7.32 0.37 1.88e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg06784218 chr1:46089804 CCDC17 0.56 11.25 0.52 4.04e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg16339924 chr4:17578868 LAP3 0.67 10.72 0.51 2.97e-23 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9549367 0.713 rs2476328 chr13:113829350 C/T cg18105134 chr13:113819100 PROZ 0.66 9.57 0.46 2.46e-19 Platelet distribution width; LUSC cis rs2652834 1.000 rs68088462 chr15:63397617 T/C cg05507819 chr15:63340323 TPM1 0.67 8.13 0.41 8.72e-15 HDL cholesterol; LUSC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.87 0.4 4.98e-14 Major depressive disorder; LUSC cis rs3126085 0.935 rs3126094 chr1:152308243 T/C cg26876637 chr1:152193138 HRNR -0.45 -6.32 -0.33 8.44e-10 Atopic dermatitis; LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.06 0.4 1.36e-14 Bipolar disorder; LUSC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg04362960 chr10:104952993 NT5C2 0.58 9.19 0.45 4.29e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg09365446 chr1:150670422 GOLPH3L -0.41 -6.15 -0.32 2.23e-9 Tonsillectomy; LUSC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg23719950 chr11:63933701 MACROD1 -0.6 -7.48 -0.38 6.57e-13 Mean platelet volume; LUSC cis rs2235649 0.552 rs8056773 chr16:1959432 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.47 -5.69 -0.3 2.76e-8 Blood metabolite levels; LUSC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs6977660 1.000 rs6959591 chr7:19821824 A/G cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg12292205 chr6:26970375 C6orf41 0.57 7.34 0.37 1.62e-12 Intelligence (multi-trait analysis); LUSC cis rs9287719 0.967 rs7587231 chr2:10740093 C/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC trans rs11039798 0.511 rs717896 chr11:48375335 G/T cg15704280 chr7:45808275 SEPT13 -0.65 -7.06 -0.36 9.8e-12 Axial length; LUSC cis rs9287719 0.967 rs7355649 chr2:10748094 C/A cg00105475 chr2:10696890 NA 0.36 6.0 0.31 5.25e-9 Prostate cancer; LUSC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.05 0.55 5.3e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19627864 chr1:16940181 NBPF1 -0.4 -5.99 -0.31 5.51e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1728785 0.688 rs698718 chr16:68560185 A/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs4073416 0.595 rs11158598 chr14:65923738 A/G cg03016385 chr14:66212404 NA -0.38 -5.89 -0.31 9.65e-9 N-glycan levels; LUSC cis rs7296418 0.961 rs12425850 chr12:123501972 T/C cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.35 -0.42 1.8e-15 Platelet count; LUSC cis rs9549367 0.789 rs9549715 chr13:113908240 G/C cg18105134 chr13:113819100 PROZ -0.69 -9.9 -0.48 2.01e-20 Platelet distribution width; LUSC cis rs12425451 0.544 rs7961302 chr12:3146436 G/C cg05389053 chr12:3131226 TEAD4 -0.43 -5.73 -0.3 2.26e-8 Narcolepsy with cataplexy; LUSC cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg09479241 chr17:27052676 TLCD1 0.43 5.78 0.3 1.74e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1729951 0.546 rs835632 chr3:136676525 A/T cg21827317 chr3:136751795 NA 0.37 6.57 0.34 1.9e-10 Neuroticism; LUSC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC cis rs11971779 0.715 rs6943973 chr7:139029893 G/C cg23387468 chr7:139079360 LUC7L2 0.42 6.34 0.33 7.52e-10 Diisocyanate-induced asthma; LUSC cis rs11264213 0.901 rs72661643 chr1:36451599 A/G cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.33e-14 Schizophrenia; LUSC cis rs10484885 0.759 rs56230212 chr6:90234654 G/A cg13799429 chr6:90582589 CASP8AP2 -0.71 -6.47 -0.33 3.49e-10 QRS interval (sulfonylurea treatment interaction); LUSC cis rs34779708 0.733 rs4444023 chr10:35548354 G/A cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11758351 1.000 rs112751982 chr6:26191958 C/T cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC cis rs8062405 0.755 rs111693583 chr16:28583610 C/T cg16576597 chr16:28551801 NUPR1 0.31 6.24 0.32 1.29e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.71 -0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs8072100 0.512 rs3809863 chr17:45385012 C/T cg25173405 chr17:45401733 C17orf57 -0.42 -6.8 -0.35 4.96e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs60843830 0.623 rs55932737 chr2:107543 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.44 6.58 0.34 1.81e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs11030122 0.673 rs11030660 chr11:4043268 T/C cg08557956 chr11:4115526 RRM1 -0.46 -5.99 -0.31 5.54e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg09455208 chr3:40491958 NA 0.57 10.09 0.48 4.35e-21 Renal cell carcinoma; LUSC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Melanoma; LUSC trans rs3808502 0.605 rs11784572 chr8:11174484 C/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.95 -0.36 1.96e-11 Neuroticism; LUSC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg06634786 chr22:41940651 POLR3H -0.55 -6.53 -0.34 2.49e-10 Vitiligo; LUSC cis rs11971779 0.715 rs10085527 chr7:139064360 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg02782426 chr3:40428986 ENTPD3 0.3 5.7 0.3 2.64e-8 Renal cell carcinoma; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg24081974 chr4:78784263 MRPL1 0.41 6.52 0.34 2.63e-10 Schizophrenia; LUSC cis rs2797160 0.935 rs60515555 chr6:126000638 T/G cg05901451 chr6:126070800 HEY2 -0.58 -8.7 -0.43 1.5e-16 Endometrial cancer; LUSC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.08 -0.44 9.9e-18 Gut microbiome composition (summer); LUSC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg05425664 chr17:57184151 TRIM37 0.59 9.19 0.45 4.42e-18 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11644478 chr21:40555479 PSMG1 0.94 18.18 0.71 7.7e-52 Cognitive function; LUSC cis rs7715806 0.500 rs72633984 chr5:75005899 A/G cg19683494 chr5:74908142 NA 0.57 7.68 0.39 1.83e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7818345 0.967 rs7004435 chr8:19282732 G/A cg11303988 chr8:19266685 CSGALNACT1 0.38 7.41 0.38 1.05e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.81 -0.3 1.49e-8 Total body bone mineral density; LUSC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg11764359 chr7:65958608 NA -0.52 -6.71 -0.34 8.17e-11 Aortic root size; LUSC cis rs1691799 0.867 rs2172881 chr12:66766039 C/G cg16791601 chr12:66731901 HELB -0.71 -12.23 -0.56 1.13e-28 White blood cell count (basophil); LUSC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg21672276 chr3:44754072 ZNF502 -0.37 -5.73 -0.3 2.24e-8 Depressive symptoms; LUSC cis rs4954585 0.708 rs10200263 chr2:137007429 C/T cg05194412 chr2:137003533 NA 0.39 7.11 0.36 7.1e-12 Colorectal cancer; LUSC trans rs9951602 0.833 rs9953548 chr18:76640601 C/T cg02800362 chr5:177631904 HNRNPAB 0.95 10.32 0.49 7.21e-22 Obesity-related traits; LUSC cis rs1670533 0.929 rs6599280 chr4:1063818 A/G cg27284194 chr4:1044797 NA 0.61 8.92 0.44 3.08e-17 Recombination rate (females); LUSC cis rs2262909 0.962 rs73019842 chr19:22249909 T/G cg11619707 chr19:22235551 ZNF257 0.39 5.83 0.3 1.29e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9399135 0.967 rs6925424 chr6:135313948 T/A cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Red blood cell count; LUSC cis rs6967385 0.560 rs7790370 chr7:12353523 G/C cg20607287 chr7:12443886 VWDE 0.5 7.5 0.38 5.88e-13 Response to taxane treatment (placlitaxel); LUSC cis rs2760061 0.819 rs3094913 chr1:228206980 T/C cg18477163 chr1:228402036 OBSCN 0.63 12.0 0.55 8e-28 Diastolic blood pressure; LUSC cis rs1595825 1.000 rs1304165 chr2:198877300 G/A cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg00376283 chr12:123451042 ABCB9 0.68 8.65 0.43 2.18e-16 Neutrophil percentage of white cells; LUSC cis rs7537052 0.564 rs6669395 chr1:36653717 A/G cg24686825 chr1:36642396 MAP7D1 -0.74 -12.93 -0.58 2.66e-31 Schizophrenia; LUSC cis rs6977660 0.943 rs9639334 chr7:19838810 G/A cg05791153 chr7:19748676 TWISTNB 0.58 6.46 0.33 3.6e-10 Thyroid stimulating hormone; LUSC trans rs1005277 0.579 rs2474587 chr10:38420666 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.77 -0.47 5.22e-20 Extrinsic epigenetic age acceleration; LUSC cis rs11051970 0.918 rs73084101 chr12:32544339 A/C cg24626660 chr12:32551988 NA 0.37 6.13 0.32 2.46e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2348418 0.864 rs7314984 chr12:28710869 C/T cg13890972 chr12:28721907 NA -0.36 -6.31 -0.33 8.63e-10 Lung function (FVC);Lung function (FEV1); LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg12564285 chr5:131593104 PDLIM4 0.44 7.92 0.4 3.63e-14 Blood metabolite levels; LUSC cis rs7809950 0.954 rs2520243 chr7:107136973 T/C cg23024343 chr7:107201750 COG5 -0.54 -8.69 -0.43 1.71e-16 Coronary artery disease; LUSC cis rs2777491 0.957 rs16971798 chr15:41657144 A/T cg18705301 chr15:41695430 NDUFAF1 0.7 13.56 0.6 1.08e-33 Ulcerative colitis; LUSC cis rs6598955 0.671 rs17163751 chr1:26568698 A/G cg00852783 chr1:26633632 UBXN11 -0.48 -5.67 -0.3 3.16e-8 Obesity-related traits; LUSC cis rs9300255 0.739 rs4759371 chr12:123742563 T/C cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.36 -0.33 6.57e-10 Neutrophil percentage of white cells; LUSC cis rs4631830 0.720 rs2611471 chr10:51503559 G/C cg10326726 chr10:51549505 MSMB -0.36 -6.3 -0.33 9.6e-10 Prostate-specific antigen levels; LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs3126085 0.935 rs10888471 chr1:152200849 G/T cg03465714 chr1:152285911 FLG 0.43 6.06 0.31 3.58e-9 Atopic dermatitis; LUSC cis rs11055008 0.620 rs10845608 chr12:12836088 C/T cg04607235 chr12:12878440 APOLD1 0.5 7.5 0.38 5.94e-13 Pulse pressure; LUSC trans rs6952808 0.723 rs60995052 chr7:2030007 G/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.41 0.33 4.9e-10 Bipolar disorder and schizophrenia; LUSC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg12311346 chr5:56204834 C5orf35 0.5 7.68 0.39 1.83e-13 Breast cancer;Breast cancer (early onset); LUSC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg03709012 chr19:19516395 GATAD2A 0.74 11.3 0.53 2.7e-25 Tonsillectomy; LUSC cis rs41271473 0.526 rs28593014 chr1:228743576 G/A cg10167378 chr1:228756711 NA 0.75 9.65 0.47 1.37e-19 Chronic lymphocytic leukemia; LUSC cis rs10089 1.000 rs10478803 chr5:127488855 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 11.7 0.54 9.93e-27 Ileal carcinoids; LUSC cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.57 -0.34 1.96e-10 Colorectal cancer; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg16769688 chr16:1823307 MRPS34;EME2 0.45 6.12 0.32 2.69e-9 Response to Homoharringtonine (cytotoxicity); LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg26668828 chr6:292823 DUSP22 -0.5 -7.34 -0.37 1.68e-12 Menopause (age at onset); LUSC trans rs17685 0.725 rs2302436 chr7:75676988 A/T cg19862616 chr7:65841803 NCRNA00174 -1.12 -19.49 -0.73 4.76e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6545883 0.894 rs2694649 chr2:61573826 G/A cg15711740 chr2:61764176 XPO1 0.43 6.59 0.34 1.73e-10 Tuberculosis; LUSC cis rs12594515 1.000 rs6493168 chr15:45986811 A/C cg19682013 chr15:45996608 NA 0.39 5.99 0.31 5.4e-9 Waist circumference;Weight; LUSC cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg22496339 chr2:162101262 NA 0.45 6.54 0.34 2.32e-10 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg08888203 chr3:10149979 C3orf24 0.65 8.29 0.41 2.78e-15 Alzheimer's disease; LUSC cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs72634258 0.786 rs9434993 chr1:8179744 G/C cg26816564 chr1:7831052 VAMP3 0.46 6.13 0.32 2.51e-9 Inflammatory bowel disease; LUSC trans rs67133203 0.796 rs1005559 chr12:51414232 T/A cg17484237 chr5:156536107 HAVCR2 0.44 5.97 0.31 6.1e-9 Urinary tract infection frequency; LUSC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg26408565 chr15:76604113 ETFA -0.48 -7.68 -0.39 1.84e-13 Blood metabolite levels; LUSC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg12365402 chr11:9010492 NRIP3 0.42 7.69 0.39 1.7e-13 Hemoglobin concentration; LUSC cis rs2228479 0.867 rs73276534 chr16:89950557 A/G cg00800038 chr16:89945340 TCF25 -0.63 -6.68 -0.34 1.02e-10 Skin colour saturation; LUSC cis rs9326248 0.652 rs7128382 chr11:117023487 A/C cg11861562 chr11:117069780 TAGLN 0.36 5.87 0.31 1.06e-8 Blood protein levels; LUSC cis rs714027 0.565 rs9614099 chr22:30288338 A/T cg11564601 chr22:30592435 NA 0.33 5.84 0.3 1.21e-8 Lymphocyte counts; LUSC cis rs9796 0.870 rs8023345 chr15:41338348 T/G cg18705301 chr15:41695430 NDUFAF1 -0.41 -7.08 -0.36 8.46e-12 Menopause (age at onset); LUSC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg15857475 chr8:145742913 RECQL4;LRRC14 -0.77 -12.8 -0.57 8.5e-31 Age at first birth; LUSC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -7.92 -0.4 3.56e-14 Type 2 diabetes; LUSC cis rs9326248 0.581 rs10892053 chr11:116857003 C/T cg11861562 chr11:117069780 TAGLN 0.33 6.32 0.33 8.42e-10 Blood protein levels; LUSC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg05623727 chr3:50126028 RBM5 0.31 5.73 0.3 2.21e-8 Intelligence (multi-trait analysis); LUSC cis rs782590 0.807 rs782642 chr2:55928444 G/T cg03859395 chr2:55845619 SMEK2 0.85 14.99 0.63 3.24e-39 Metabolic syndrome; LUSC cis rs7084921 0.608 rs2862948 chr10:101864173 A/G cg11888571 chr10:102027403 CWF19L1 -0.42 -5.9 -0.31 8.71e-9 Bone mineral density; LUSC cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg00745463 chr17:30367425 LRRC37B 0.87 8.55 0.42 4.49e-16 Hip circumference adjusted for BMI; LUSC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg12288994 chr5:1860383 NA 0.28 6.18 0.32 1.9e-9 Cardiovascular disease risk factors; LUSC cis rs3749237 0.964 rs13084243 chr3:49821878 G/C cg03060546 chr3:49711283 APEH 0.61 8.41 0.42 1.24e-15 Resting heart rate; LUSC cis rs7582180 0.739 rs4851292 chr2:100924761 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg13126279 chr21:47581558 C21orf56 -0.41 -5.83 -0.3 1.31e-8 Testicular germ cell tumor; LUSC cis rs2050392 0.517 rs602966 chr10:30755853 C/T cg18806716 chr10:30721971 MAP3K8 -0.58 -9.18 -0.45 4.62e-18 Inflammatory bowel disease; LUSC cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg11102782 chr19:18549136 ISYNA1 -0.34 -6.46 -0.33 3.6e-10 Breast cancer; LUSC trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs2839186 0.967 rs4819222 chr21:47707778 G/A cg13126279 chr21:47581558 C21orf56 -0.41 -6.03 -0.31 4.29e-9 Testicular germ cell tumor; LUSC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg00343986 chr7:65444356 GUSB 0.43 6.56 0.34 2.07e-10 Aortic root size; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg15242686 chr22:24348715 GSTTP1 0.54 8.56 0.42 4.05e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6121246 0.697 rs6060912 chr20:30325755 C/A cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs834603 0.546 rs1704973 chr7:47483705 T/C cg09696706 chr7:47479511 TNS3 0.34 6.06 0.31 3.65e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs367943 0.712 rs27567 chr5:112741798 C/T cg12552261 chr5:112820674 MCC 0.36 6.05 0.31 3.85e-9 Type 2 diabetes; LUSC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg04775059 chr7:64541387 NA 0.48 6.97 0.36 1.7e-11 Calcium levels; LUSC cis rs12579753 0.810 rs1922565 chr12:82135348 T/C cg07988820 chr12:82153109 PPFIA2 -0.45 -6.46 -0.33 3.7e-10 Resting heart rate; LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13732083 chr21:47605072 C21orf56 -0.43 -6.24 -0.32 1.32e-9 Testicular germ cell tumor; LUSC cis rs8040855 0.627 rs3816105 chr15:85640911 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.39 -5.81 -0.3 1.45e-8 Bulimia nervosa; LUSC cis rs4919694 1.000 rs11191525 chr10:104793435 G/C cg04362960 chr10:104952993 NT5C2 1.17 13.66 0.6 4.72e-34 Arsenic metabolism; LUSC cis rs983392 0.679 rs72920867 chr11:60005424 T/C cg24026212 chr11:59952134 MS4A6A -0.35 -5.93 -0.31 7.37e-9 Alzheimer's disease (late onset); LUSC cis rs11098499 0.954 rs3733524 chr4:120423729 T/C cg09307838 chr4:120376055 NA 0.78 11.42 0.53 9.85e-26 Corneal astigmatism; LUSC cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg08807101 chr21:30365312 RNF160 -0.71 -12.2 -0.56 1.46e-28 Dental caries; LUSC cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.8 -11.66 -0.54 1.32e-26 Chronic sinus infection; LUSC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.91 -0.4 3.78e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg16797656 chr11:68205561 LRP5 0.36 5.94 0.31 7.09e-9 Total body bone mineral density; LUSC trans rs12914656 0.556 rs34347645 chr15:86659428 C/A cg27136844 chr3:147142355 NA -0.41 -6.23 -0.32 1.42e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs12220238 1.000 rs4745740 chr10:75942469 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.22 0.37 3.49e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.41 6.3 0.33 9.28e-10 Platelet count; LUSC cis rs7759001 0.817 rs4339442 chr6:27372127 A/T cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg15994321 chr1:161736098 ATF6 0.38 6.14 0.32 2.37e-9 Asthma; LUSC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.52 0.38 5.14e-13 Electroencephalogram traits; LUSC cis rs11608355 0.545 rs2302703 chr12:109898832 G/A cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg10523679 chr1:76189770 ACADM 0.88 13.67 0.6 4.25e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11148252 0.514 rs3818422 chr13:52719214 C/T cg00495681 chr13:53174319 NA -0.42 -6.36 -0.33 6.58e-10 Lewy body disease; LUSC cis rs7605827 0.930 rs1015836 chr2:15665719 A/G cg19274914 chr2:15703543 NA -0.42 -8.5 -0.42 6.36e-16 Educational attainment (years of education); LUSC cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg09469691 chr10:81107165 PPIF 0.63 9.94 0.48 1.47e-20 Height; LUSC cis rs62400317 0.826 rs12216308 chr6:45342305 T/G cg18551225 chr6:44695536 NA -0.44 -7.3 -0.37 2.06e-12 Total body bone mineral density; LUSC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.58 -0.38 3.45e-13 Menopause (age at onset); LUSC cis rs9462027 0.606 rs2235569 chr6:34570070 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.15 -0.32 2.19e-9 Systemic lupus erythematosus; LUSC trans rs800082 0.516 rs4511940 chr3:144219392 T/C cg24215973 chr2:240111563 HDAC4 0.44 6.64 0.34 1.27e-10 Smoking behavior; LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs6840360 0.615 rs56319216 chr4:152463716 C/T cg22705602 chr4:152727874 NA -0.32 -6.47 -0.33 3.41e-10 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg06784218 chr1:46089804 CCDC17 -0.58 -11.55 -0.53 3.58e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs748404 0.697 rs530188 chr15:43545314 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.79 0.39 8.69e-14 Lung cancer; LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg24060327 chr5:131705240 SLC22A5 0.48 7.45 0.38 8.06e-13 Acylcarnitine levels; LUSC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg04733989 chr22:42467013 NAGA 0.6 9.35 0.46 1.26e-18 Schizophrenia; LUSC trans rs60843830 1.000 rs3791221 chr2:226933 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.34 0.49 6.5600000000000005e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs912057 0.671 rs1294420 chr6:6742752 C/T cg06612196 chr6:6737390 NA 0.56 11.14 0.52 9.79e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC trans rs7951105 0.867 rs11035162 chr11:39251033 A/C cg24085930 chr3:21832523 NA 0.49 6.05 0.31 3.94e-9 Free thyroxine concentration; LUSC trans rs4252134 0.959 rs4252096 chr6:161134273 C/G cg15416064 chr12:49209402 NA -0.43 -6.01 -0.31 4.86e-9 Giant cell arteritis; LUSC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg08219700 chr8:58056026 NA 0.68 7.97 0.4 2.49e-14 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg06481639 chr22:41940642 POLR3H -0.51 -6.22 -0.32 1.5e-9 Vitiligo; LUSC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg02782426 chr3:40428986 ENTPD3 0.34 6.39 0.33 5.66e-10 Renal cell carcinoma; LUSC cis rs9309473 0.687 rs6546827 chr2:73606493 C/T cg20560298 chr2:73613845 ALMS1 -0.52 -7.45 -0.38 7.99e-13 Metabolite levels; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg12016809 chr21:47604291 C21orf56 -0.45 -6.71 -0.34 8.23e-11 Testicular germ cell tumor; LUSC cis rs877282 1.000 rs11253367 chr10:773389 G/A cg17470449 chr10:769945 NA 0.52 7.29 0.37 2.32e-12 Uric acid levels; LUSC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg12923728 chr3:195709715 SDHAP1 -0.78 -12.27 -0.56 8.07e-29 Pancreatic cancer; LUSC cis rs5770917 1.000 rs2269385 chr22:51010939 G/A cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.65 -5.7 -0.3 2.65e-8 Narcolepsy; LUSC cis rs4363385 0.509 rs11576882 chr1:152918785 T/G cg00922841 chr1:152955080 SPRR1A -0.36 -5.94 -0.31 7.09e-9 Inflammatory skin disease; LUSC cis rs3857536 0.776 rs9342535 chr6:66932963 C/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg18240062 chr17:79603768 NPLOC4 0.59 10.07 0.48 5.3e-21 Eye color traits; LUSC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg18827107 chr12:86230957 RASSF9 -0.44 -6.56 -0.34 2.07e-10 Major depressive disorder; LUSC trans rs7618501 0.633 rs4688757 chr3:50035323 T/C cg21659725 chr3:3221576 CRBN 0.64 10.59 0.5 8.53e-23 Intelligence (multi-trait analysis); LUSC cis rs17270561 0.636 rs4145218 chr6:25746083 G/A cg17691542 chr6:26056736 HIST1H1C 0.59 8.19 0.41 5.46e-15 Iron status biomarkers; LUSC cis rs459571 0.920 rs460154 chr9:136909309 C/T cg01294253 chr9:136912663 BRD3 0.34 5.99 0.31 5.41e-9 Platelet distribution width; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg10802521 chr3:52805072 NEK4 0.58 9.33 0.45 1.56e-18 Bipolar disorder; LUSC cis rs7408868 1.000 rs7254735 chr19:15263385 A/G cg14696996 chr19:15285081 NOTCH3 0.93 8.77 0.43 9.25e-17 Pulse pressure; LUSC cis rs2274273 0.624 rs8014477 chr14:55841477 A/G cg04306507 chr14:55594613 LGALS3 -0.46 -9.55 -0.46 2.88e-19 Protein biomarker; LUSC cis rs6500395 0.962 rs9922356 chr16:48640025 C/T cg04672837 chr16:48644449 N4BP1 0.47 6.66 0.34 1.16e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7223966 1.000 rs7220892 chr17:61908316 G/A cg05941027 chr17:61774174 LIMD2 0.21 5.77 0.3 1.83e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.64e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6565180 1.000 rs11646130 chr16:30376959 T/C cg17640201 chr16:30407289 ZNF48 -0.87 -14.74 -0.63 3.17e-38 Tonsillectomy; LUSC cis rs7264396 0.635 rs6060682 chr20:34506331 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.94 -0.44 2.7e-17 Total cholesterol levels; LUSC cis rs9467773 0.620 rs9295701 chr6:26627508 T/C cg11502198 chr6:26597334 ABT1 0.72 12.12 0.55 2.76e-28 Intelligence (multi-trait analysis); LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg17178900 chr1:205818956 PM20D1 0.8 13.48 0.59 2.24e-33 Menarche (age at onset); LUSC cis rs2073300 0.536 rs6137947 chr20:23414630 C/A cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg02753203 chr1:228287806 NA -0.65 -11.02 -0.52 2.77e-24 Diastolic blood pressure; LUSC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg27286337 chr10:134555280 INPP5A 0.92 12.18 0.55 1.78e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4363385 0.571 rs387930 chr1:153050058 A/G cg00922841 chr1:152955080 SPRR1A -0.41 -6.84 -0.35 3.9e-11 Inflammatory skin disease; LUSC cis rs826838 0.904 rs10876086 chr12:39188208 C/A cg26384229 chr12:38710491 ALG10B 0.89 16.7 0.67 5.82e-46 Heart rate; LUSC trans rs2806864 1.000 rs2250865 chr1:117462691 A/G cg04557197 chr17:77764992 NA 0.65 6.01 0.31 4.75e-9 Erectile dysfunction and prostate cancer treatment; LUSC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg09703963 chr11:616879 IRF7;MUPCDH -0.45 -7.15 -0.36 5.4e-12 Systemic lupus erythematosus; LUSC cis rs143985986 1 rs143985986 chr3:58399886 TC/T cg26110898 chr3:58419937 PDHB 0.39 6.29 0.33 9.72e-10 Hematocrit; LUSC cis rs701145 0.529 rs355759 chr3:154008078 G/C cg10247383 chr3:153839028 SGEF -0.47 -5.79 -0.3 1.61e-8 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09077966 chr16:89724782 C16orf55;CHMP1A 0.42 6.21 0.32 1.53e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.747 rs2425158 chr20:34419664 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.95 -0.44 2.43e-17 Total cholesterol levels; LUSC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.62 6.15 0.32 2.16e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7605827 0.930 rs13024118 chr2:15494640 A/T cg19274914 chr2:15703543 NA 0.44 8.31 0.41 2.47e-15 Educational attainment (years of education); LUSC cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs9430161 0.611 rs72644043 chr1:11033051 T/A cg02454025 chr1:11042201 C1orf127 1.03 18.59 0.71 1.91e-53 Ewing sarcoma; LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg13126279 chr21:47581558 C21orf56 0.47 7.05 0.36 1e-11 Testicular germ cell tumor; LUSC cis rs12900413 0.687 rs13343248 chr15:90311226 A/T cg24249390 chr15:90295951 MESP1 -0.37 -5.91 -0.31 8.6e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg13256891 chr4:100009986 ADH5 0.4 5.66 0.3 3.23e-8 Alcohol dependence; LUSC cis rs11690935 0.802 rs34636594 chr2:172911094 A/G cg13550731 chr2:172543902 DYNC1I2 -0.82 -12.85 -0.58 5.62e-31 Schizophrenia; LUSC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg14552801 chr7:65878734 NA -0.43 -5.89 -0.31 9.49e-9 Aortic root size; LUSC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.39 6.28 0.33 1.04e-9 Menopause (age at onset); LUSC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg03709012 chr19:19516395 GATAD2A 0.83 13.76 0.6 1.89e-34 Tonsillectomy; LUSC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.39 7.65 0.39 2.13e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7107174 1.000 rs10899492 chr11:78109810 G/A cg02023728 chr11:77925099 USP35 0.42 6.26 0.32 1.19e-9 Testicular germ cell tumor; LUSC cis rs9463078 0.764 rs1576382 chr6:44957553 G/A cg25276700 chr6:44698697 NA -0.28 -5.72 -0.3 2.43e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg23711669 chr6:146136114 FBXO30 0.74 13.07 0.58 7.88e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14757344 chr21:45209507 RRP1 -0.45 -6.59 -0.34 1.7e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg18876405 chr7:65276391 NA 0.7 12.3 0.56 6.32e-29 Aortic root size; LUSC cis rs9300255 0.739 rs11057210 chr12:123733799 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.05 -0.31 3.97e-9 Neutrophil percentage of white cells; LUSC cis rs1865721 0.682 rs7242637 chr18:73147492 A/C cg26385618 chr18:73139727 C18orf62 -0.47 -8.78 -0.43 8.7e-17 Intelligence; LUSC cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg24562669 chr7:97807699 LMTK2 0.4 6.78 0.35 5.32e-11 Breast cancer; LUSC cis rs55665837 0.559 rs11023210 chr11:14422762 A/G cg19336497 chr11:14380999 RRAS2 0.55 11.62 0.54 1.95e-26 Vitamin D levels; LUSC cis rs6076065 0.723 rs2253924 chr20:23388020 G/A cg11657817 chr20:23433608 CST11 0.42 8.01 0.4 1.94e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs909341 0.909 rs2427532 chr20:62363817 G/A cg09650180 chr20:62225654 GMEB2 -0.45 -5.81 -0.3 1.48e-8 Atopic dermatitis; LUSC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg21918786 chr6:109611834 NA 0.42 7.32 0.37 1.92e-12 Reticulocyte fraction of red cells; LUSC cis rs2115630 0.764 rs11073716 chr15:85335774 C/T cg09876464 chr15:85330779 ZNF592 0.37 6.78 0.35 5.36e-11 P wave terminal force; LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg16405210 chr4:1374714 KIAA1530 -0.78 -12.51 -0.56 1.03e-29 Longevity; LUSC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg08975724 chr8:8085496 FLJ10661 -0.49 -6.85 -0.35 3.54e-11 Neuroticism; LUSC cis rs6469656 1.000 rs4335153 chr8:117651448 A/T cg24004040 chr8:117650383 NA -0.43 -6.22 -0.32 1.46e-9 Colorectal cancer; LUSC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg17264618 chr3:40429014 ENTPD3 -0.32 -6.43 -0.33 4.37e-10 Renal cell carcinoma; LUSC cis rs965469 0.947 rs965468 chr20:3381443 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -5.74 -0.3 2.17e-8 IFN-related cytopenia; LUSC cis rs921968 0.541 rs10200507 chr2:219335944 C/A cg02176678 chr2:219576539 TTLL4 -0.74 -14.38 -0.62 8.23e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs2046867 0.818 rs62249862 chr3:72867949 G/C cg25664220 chr3:72788482 NA -0.71 -11.91 -0.55 1.71e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg11887960 chr12:57824829 NA 0.59 7.66 0.39 2.07e-13 Lung disease severity in cystic fibrosis; LUSC cis rs4595586 0.545 rs7486598 chr12:39371159 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.95 0.36 1.93e-11 Morning vs. evening chronotype; LUSC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg24733560 chr20:60626293 TAF4 0.42 7.59 0.38 3.15e-13 Body mass index; LUSC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs921968 0.643 rs508157 chr2:219435288 G/A cg02176678 chr2:219576539 TTLL4 0.61 11.03 0.52 2.41e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.18 0.37 4.6e-12 Bipolar disorder; LUSC cis rs599083 0.829 rs314751 chr11:68179560 C/T cg16797656 chr11:68205561 LRP5 -0.36 -5.86 -0.31 1.12e-8 Bone mineral density (spine); LUSC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg19774624 chr17:42201019 HDAC5 0.83 14.44 0.62 4.62e-37 Total body bone mineral density; LUSC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.47 0.38 6.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7107174 0.681 rs10751288 chr11:78072658 A/T cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs9398803 0.865 rs9385399 chr6:126759033 A/C cg19875578 chr6:126661172 C6orf173 -0.43 -6.42 -0.33 4.55e-10 Male-pattern baldness; LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs12200782 1.000 rs4515370 chr6:26625319 T/C cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs524023 0.874 rs519090 chr11:64456240 G/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.5 -0.5 1.75e-22 Urate levels in obese individuals; LUSC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg12751644 chr20:60527061 NA -0.34 -6.16 -0.32 2.07e-9 Body mass index; LUSC cis rs13108904 0.870 rs3733338 chr4:1241472 G/A cg20887711 chr4:1340912 KIAA1530 0.42 6.33 0.33 7.96e-10 Obesity-related traits; LUSC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.16 -0.32 2.12e-9 Extrinsic epigenetic age acceleration; LUSC cis rs9911578 0.967 rs6503890 chr17:57064167 A/G cg05425664 chr17:57184151 TRIM37 -0.57 -8.43 -0.42 1.09e-15 Intelligence (multi-trait analysis); LUSC cis rs17270561 0.609 rs7770037 chr6:25760591 G/A cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs193541 0.626 rs10079456 chr5:122090442 G/A cg19077854 chr5:122220652 SNX24 0.28 6.26 0.32 1.18e-9 Glucose homeostasis traits; LUSC cis rs9326248 0.581 rs10502222 chr11:116833730 C/T cg11861562 chr11:117069780 TAGLN 0.33 6.36 0.33 6.48e-10 Blood protein levels; LUSC cis rs7833787 0.832 rs7827258 chr8:18698295 G/C cg17701159 chr8:18705777 PSD3 -0.36 -5.88 -0.31 1.02e-8 Obesity-related traits; LUSC cis rs10782582 0.609 rs2029682 chr1:76341619 T/C cg03433033 chr1:76189801 ACADM -0.43 -6.24 -0.32 1.33e-9 Daytime sleep phenotypes; LUSC trans rs61931739 0.500 rs7311284 chr12:34478477 C/G cg26384229 chr12:38710491 ALG10B 0.9 15.7 0.65 5.49e-42 Morning vs. evening chronotype; LUSC cis rs6684514 0.506 rs3762281 chr1:156304782 A/G cg20302342 chr1:156215951 PAQR6 0.31 5.82 0.3 1.39e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs11997175 0.583 rs17780571 chr8:33817821 G/C ch.8.33884649F chr8:33765107 NA 0.45 6.47 0.33 3.56e-10 Body mass index; LUSC cis rs2281558 0.837 rs56238023 chr20:25516947 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.62 9.33 0.45 1.52e-18 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs950776 0.507 rs12912673 chr15:78810216 T/C cg22563815 chr15:78856949 CHRNA5 0.27 6.41 0.33 4.82e-10 Sudden cardiac arrest; LUSC cis rs941408 0.515 rs12610096 chr19:2778129 C/T cg17333051 chr19:2783644 SGTA 0.51 7.59 0.38 3.32e-13 Total cholesterol levels; LUSC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg00343986 chr7:65444356 GUSB -0.43 -6.42 -0.33 4.74e-10 Aortic root size; LUSC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg26554054 chr8:600488 NA -0.61 -6.32 -0.33 8.37e-10 IgG glycosylation; LUSC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.09 14.43 0.62 5.1e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7824557 0.510 rs2736297 chr8:11234885 C/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.5 -0.38 5.71e-13 Retinal vascular caliber; LUSC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg18190219 chr22:46762943 CELSR1 -0.48 -6.0 -0.31 5.03e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg04282206 chr17:62833786 PLEKHM1P -0.42 -6.18 -0.32 1.83e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7937682 0.889 rs559482 chr11:111497902 G/A cg22437258 chr11:111473054 SIK2 0.52 7.01 0.36 1.33e-11 Primary sclerosing cholangitis; LUSC cis rs2404602 0.569 rs2469249 chr15:76772062 C/T cg22467129 chr15:76604101 ETFA 0.4 5.65 0.3 3.41e-8 Blood metabolite levels; LUSC cis rs7605827 0.930 rs11896745 chr2:15515373 C/T cg19274914 chr2:15703543 NA 0.46 8.77 0.43 9.32e-17 Educational attainment (years of education); LUSC cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg03146154 chr1:46216737 IPP -0.58 -8.34 -0.41 2.04e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2729354 0.768 rs2584856 chr11:57267312 C/A cg24343310 chr11:57249947 NA 0.43 8.32 0.41 2.19e-15 Blood protein levels; LUSC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.18e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7927771 0.507 rs7119517 chr11:47675316 T/C cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; LUSC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg00409905 chr10:38381863 ZNF37A 0.4 6.8 0.35 4.88e-11 Extrinsic epigenetic age acceleration; LUSC cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC trans rs61931739 0.500 rs11836198 chr12:34552782 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs2274273 0.870 rs8021583 chr14:55749607 G/A cg04306507 chr14:55594613 LGALS3 0.54 12.06 0.55 4.93e-28 Protein biomarker; LUSC cis rs61931739 0.500 rs11053290 chr12:34582392 C/T cg06521331 chr12:34319734 NA 0.42 6.85 0.35 3.6e-11 Morning vs. evening chronotype; LUSC cis rs35146811 0.659 rs863450 chr7:99821685 C/T cg13334819 chr7:99746414 C7orf59 0.49 6.5 0.34 2.96e-10 Coronary artery disease; LUSC cis rs9905704 0.846 rs304267 chr17:56799380 A/G cg12560992 chr17:57184187 TRIM37 0.58 8.4 0.42 1.34e-15 Testicular germ cell tumor; LUSC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -7.99 -0.4 2.25e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.94 13.01 0.58 1.35e-31 Gut microbiome composition (summer); LUSC trans rs941408 0.515 rs759067 chr19:2775668 C/T cg19676328 chr12:49525230 TUBA1B -0.52 -7.39 -0.37 1.19e-12 Total cholesterol levels; LUSC cis rs12210905 1.000 rs1102557 chr6:27149794 C/A cg11502198 chr6:26597334 ABT1 0.79 5.66 0.3 3.22e-8 Hip circumference adjusted for BMI; LUSC cis rs13202913 0.733 rs13215869 chr6:151803659 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.56 5.7 0.3 2.67e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg09034736 chr1:150693464 HORMAD1 0.42 5.92 0.31 7.92e-9 Melanoma; LUSC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg07636037 chr3:49044803 WDR6 0.44 6.29 0.33 1.01e-9 Resting heart rate; LUSC cis rs4919087 0.851 rs2297987 chr10:98989454 C/T cg25902810 chr10:99078978 FRAT1 -0.4 -5.8 -0.3 1.57e-8 Monocyte count; LUSC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg05340658 chr4:99064831 C4orf37 0.65 10.82 0.51 1.34e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg05283184 chr6:79620031 NA -0.57 -12.12 -0.55 2.96e-28 Intelligence (multi-trait analysis); LUSC cis rs79349575 0.721 rs4794004 chr17:47038471 C/T cg22482690 chr17:47019901 SNF8 0.37 7.0 0.36 1.43e-11 Type 2 diabetes; LUSC cis rs6542838 0.646 rs17756034 chr2:99382810 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -5.81 -0.3 1.44e-8 Fear of minor pain; LUSC cis rs2274273 0.837 rs7146748 chr14:55747086 G/A cg04306507 chr14:55594613 LGALS3 0.57 13.34 0.59 7.78e-33 Protein biomarker; LUSC cis rs6964587 0.869 rs34791781 chr7:91532720 C/T cg17063962 chr7:91808500 NA -0.53 -8.18 -0.41 6.04e-15 Breast cancer; LUSC trans rs35110281 0.641 rs4819283 chr21:45083011 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 9.98 0.48 1.09e-20 Mean corpuscular volume; LUSC cis rs66887589 0.592 rs11731571 chr4:120221185 G/A cg09307838 chr4:120376055 NA 0.55 8.26 0.41 3.56e-15 Diastolic blood pressure; LUSC cis rs2688608 0.592 rs13013 chr10:75562161 C/A cg23231163 chr10:75533350 FUT11 -0.43 -6.86 -0.35 3.39e-11 Inflammatory bowel disease; LUSC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg12311346 chr5:56204834 C5orf35 -1.01 -14.58 -0.62 1.33e-37 Initial pursuit acceleration; LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.84 -0.57 5.91e-31 Alzheimer's disease; LUSC trans rs73019876 0.901 rs2666440 chr19:22139345 G/T cg16204205 chr18:19753432 GATA6 0.31 5.94 0.31 7.01e-9 Testicular germ cell tumor; LUSC cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.4 0.49 4.04e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.512 rs11181007 chr12:38266700 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.97 -0.36 1.72e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg26897989 chr16:1907736 C16orf73 -0.45 -7.02 -0.36 1.28e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg13319975 chr6:146136371 FBXO30 -0.45 -6.59 -0.34 1.69e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs73198271 0.813 rs17697237 chr8:8615874 A/C cg15556689 chr8:8085844 FLJ10661 0.45 6.04 0.31 4.15e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1003719 0.591 rs2835633 chr21:38525019 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -9.4 -0.46 8.68e-19 Eye color traits; LUSC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg17971929 chr21:40555470 PSMG1 -0.47 -7.13 -0.36 6.12e-12 Menarche (age at onset); LUSC cis rs2075165 0.901 rs6701440 chr1:156249505 A/G cg20302342 chr1:156215951 PAQR6 0.32 6.09 0.32 3.11e-9 Tonsillectomy; LUSC cis rs7917772 0.560 rs3862030 chr10:104327584 A/G cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg15445000 chr17:37608096 MED1 0.37 6.72 0.35 7.63e-11 Glomerular filtration rate (creatinine); LUSC cis rs7615952 0.515 rs7637246 chr3:125678706 A/G cg05084668 chr3:125655381 ALG1L -0.68 -10.22 -0.49 1.67e-21 Blood pressure (smoking interaction); LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg15673029 chr19:46234190 FBXO46 0.41 6.05 0.31 3.95e-9 Schizophrenia (age at onset); LUSC cis rs17102423 0.594 rs1271582 chr14:65564703 T/G cg11161011 chr14:65562177 MAX -0.71 -10.82 -0.51 1.33e-23 Obesity-related traits; LUSC cis rs6500395 0.925 rs16946342 chr16:48668542 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.74 0.35 6.83e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs1493916 0.967 rs9953768 chr18:31399468 A/G cg15819921 chr19:927150 ARID3A -0.43 -6.41 -0.33 5.02e-10 Life satisfaction; LUSC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg05738196 chr6:26577821 NA -0.48 -7.06 -0.36 9.54e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs1577917 1.000 rs6923148 chr6:86767786 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.24 0.41 3.99e-15 Response to antipsychotic treatment; LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.42 -0.33 4.79e-10 Bipolar disorder and schizophrenia; LUSC cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg23649088 chr2:200775458 C2orf69 -0.47 -6.31 -0.33 8.98e-10 Schizophrenia; LUSC cis rs2295359 0.824 rs11209003 chr1:67601132 G/T cg12940439 chr1:67600707 NA 0.37 5.92 0.31 7.98e-9 Psoriasis; LUSC cis rs7208859 0.623 rs9916725 chr17:29107471 A/C cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg22442454 chr1:209979470 IRF6 0.43 5.9 0.31 9.14e-9 Cleft lip with or without cleft palate; LUSC trans rs1994135 0.715 rs10844624 chr12:33691010 A/G cg26384229 chr12:38710491 ALG10B 0.66 9.57 0.46 2.43e-19 Resting heart rate; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg21782813 chr7:2030301 MAD1L1 -0.51 -9.08 -0.44 9.66e-18 Bipolar disorder and schizophrenia; LUSC cis rs6840360 1.000 rs6535818 chr4:152650882 T/G cg22705602 chr4:152727874 NA -0.28 -6.05 -0.31 3.8e-9 Intelligence (multi-trait analysis); LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg07332563 chr6:291687 DUSP22 -0.46 -6.75 -0.35 6.71e-11 Menopause (age at onset); LUSC trans rs6952808 0.965 rs4719318 chr7:1887930 G/A cg24247370 chr13:99142703 STK24 -0.35 -6.46 -0.33 3.62e-10 Bipolar disorder and schizophrenia; LUSC cis rs870825 0.616 rs6844588 chr4:185644517 T/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg04267008 chr7:1944627 MAD1L1 -0.59 -8.87 -0.44 4.47e-17 Bipolar disorder and schizophrenia; LUSC cis rs9322817 0.653 rs2400051 chr6:105169478 A/C cg02098413 chr6:105308735 HACE1 -0.28 -5.66 -0.3 3.18e-8 Thyroid stimulating hormone; LUSC cis rs7804356 1.000 rs3801843 chr7:26830201 A/G cg03456212 chr7:26904342 SKAP2 -0.55 -6.56 -0.34 2.08e-10 Type 1 diabetes; LUSC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg24675056 chr1:15929824 NA 0.46 7.92 0.4 3.44e-14 Systolic blood pressure; LUSC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg16049864 chr8:95962084 TP53INP1 -0.64 -12.63 -0.57 3.85e-30 Type 2 diabetes; LUSC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg20243544 chr17:37824526 PNMT 0.39 5.93 0.31 7.49e-9 Self-reported allergy; LUSC cis rs4654899 0.865 rs6658526 chr1:21391314 A/G cg01072550 chr1:21505969 NA 0.48 6.97 0.36 1.69e-11 Superior frontal gyrus grey matter volume; LUSC cis rs35264875 1.000 rs1542334 chr11:68850773 G/C cg02660097 chr11:68866761 NA 0.43 6.1 0.32 2.9e-9 Blond vs. brown hair color; LUSC trans rs12200782 1.000 rs12195971 chr6:26460424 G/A cg11837749 chr1:55047332 ACOT11 0.57 5.97 0.31 6.19e-9 Small cell lung carcinoma; LUSC cis rs1014246 0.848 rs11197798 chr10:118457277 C/T cg14919929 chr10:118506882 NA 0.45 7.16 0.36 5.33e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9513627 1.000 rs7321269 chr13:100126271 C/T cg25919922 chr13:100150906 NA -0.74 -6.55 -0.34 2.2e-10 Obesity-related traits; LUSC cis rs6674970 1.000 rs4970941 chr1:151068546 A/G cg03258749 chr1:151040405 MLLT11 -0.44 -6.62 -0.34 1.44e-10 Childhood ear infection; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg06873352 chr17:61820015 STRADA 0.72 12.96 0.58 2.1e-31 Prudent dietary pattern; LUSC cis rs17401966 1.000 rs4348727 chr1:10265606 G/A cg19773385 chr1:10388646 KIF1B -0.52 -8.05 -0.4 1.44e-14 Hepatocellular carcinoma; LUSC cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg15839431 chr19:19639596 YJEFN3 0.61 6.6 0.34 1.63e-10 Bipolar disorder; LUSC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.67 0.39 1.91e-13 Crohn's disease; LUSC cis rs2236918 0.710 rs1776174 chr1:242031839 G/T cg17736920 chr1:242011382 EXO1 0.41 6.48 0.33 3.25e-10 Menopause (age at onset); LUSC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg03433033 chr1:76189801 ACADM 0.81 13.3 0.59 1.06e-32 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs28735056 1.000 rs28735056 chr18:77622879 A/G cg03973167 chr4:185394988 IRF2 0.42 6.06 0.31 3.6e-9 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10350352 chr3:169487235 ARPM1 -0.43 -6.59 -0.34 1.67e-10 Triglycerides; LUSC cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg07148914 chr20:33460835 GGT7 -0.51 -8.04 -0.4 1.53e-14 Glomerular filtration rate (creatinine); LUSC cis rs3099143 1.000 rs7172639 chr15:77165288 G/A cg21673338 chr15:77095150 SCAPER 0.81 7.7 0.39 1.56e-13 Recalcitrant atopic dermatitis; LUSC cis rs796364 0.662 rs11688415 chr2:201143409 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.57 5.94 0.31 7.16e-9 Schizophrenia; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.1 0.41 1.05e-14 Prudent dietary pattern; LUSC cis rs806215 0.950 rs3735644 chr7:127222157 G/A cg25922125 chr7:127225783 GCC1 -0.61 -7.37 -0.37 1.31e-12 Type 2 diabetes; LUSC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg21770322 chr7:97807741 LMTK2 0.41 7.12 0.36 6.82e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg17971929 chr21:40555470 PSMG1 0.75 12.01 0.55 7.57e-28 Cognitive function; LUSC cis rs3743266 0.613 rs7180766 chr15:60774493 C/T cg21667061 chr15:60772094 NARG2 -0.38 -6.34 -0.33 7.53e-10 Menarche (age at onset); LUSC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.67 0.34 1.09e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11866815 0.901 rs9938786 chr16:399054 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.4 6.18 0.32 1.83e-9 Body mass index; LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg16606324 chr3:10149918 C3orf24 0.58 8.28 0.41 2.99e-15 Alzheimer's disease; LUSC cis rs3857536 0.706 rs7749120 chr6:66889832 T/G cg07460842 chr6:66804631 NA -0.47 -6.54 -0.34 2.29e-10 Blood trace element (Cu levels); LUSC cis rs1451375 0.698 rs7797131 chr7:50647934 A/G cg18232548 chr7:50535776 DDC 0.5 7.58 0.38 3.49e-13 Malaria; LUSC cis rs7264396 0.790 rs6060542 chr20:34249061 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.68 -0.47 1.09e-19 Total cholesterol levels; LUSC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg05805236 chr11:65401703 PCNXL3 -0.38 -5.8 -0.3 1.54e-8 Breast cancer; LUSC cis rs2692947 0.759 rs11687113 chr2:96658588 A/G cg23100626 chr2:96804247 ASTL 0.25 6.07 0.32 3.4e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7264396 0.513 rs2425092 chr20:34306815 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.61 -0.43 2.97e-16 Total cholesterol levels; LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.52 -6.84 -0.35 3.75e-11 Renal function-related traits (BUN); LUSC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.71 12.02 0.55 6.69e-28 Prudent dietary pattern; LUSC cis rs6546537 0.550 rs7568057 chr2:69877783 T/G cg10773587 chr2:69614142 GFPT1 -0.36 -5.89 -0.31 9.61e-9 Serum thyroid-stimulating hormone levels; LUSC cis rs412000 0.560 rs4793583 chr17:56451407 A/C cg12560992 chr17:57184187 TRIM37 -0.66 -11.67 -0.54 1.26e-26 Primary tooth development (time to first tooth eruption); LUSC cis rs10140922 0.931 rs4982258 chr14:35821891 G/A cg07166546 chr14:35805898 NA -0.24 -5.89 -0.31 9.53e-9 Hip circumference adjusted for BMI; LUSC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg02569458 chr12:86230093 RASSF9 0.58 9.93 0.48 1.6e-20 Major depressive disorder; LUSC cis rs6598955 0.585 rs12138111 chr1:26590432 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg06238570 chr21:40685208 BRWD1 -0.48 -7.47 -0.38 6.85e-13 Cognitive function; LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg25767906 chr1:53392781 SCP2 0.48 8.69 0.43 1.67e-16 Monocyte count; LUSC cis rs6912958 0.630 rs9450726 chr6:88236728 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.46 -8.79 -0.43 8.04e-17 Monocyte percentage of white cells; LUSC cis rs7582180 0.764 rs920269 chr2:100918363 G/A cg08017756 chr2:100939284 LONRF2 -0.44 -8.33 -0.41 2.09e-15 Intelligence (multi-trait analysis); LUSC cis rs1691799 0.867 rs1027399 chr12:66760942 G/A cg16791601 chr12:66731901 HELB -0.71 -12.26 -0.56 8.96e-29 White blood cell count (basophil); LUSC cis rs2289583 0.544 rs12050759 chr15:75265191 G/A cg10253484 chr15:75165896 SCAMP2 0.43 5.8 0.3 1.56e-8 Systemic lupus erythematosus; LUSC cis rs10911251 0.528 rs4652779 chr1:183104552 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.21 0.52 5.75e-25 Colorectal cancer; LUSC cis rs778371 1.000 rs778370 chr2:233743363 C/T cg08000102 chr2:233561755 GIGYF2 -0.74 -11.26 -0.52 3.85e-25 Schizophrenia; LUSC cis rs6681460 1.000 rs10789210 chr1:67066030 G/A cg02459107 chr1:67143332 SGIP1 0.48 8.85 0.44 5.02e-17 Presence of antiphospholipid antibodies; LUSC cis rs231513 0.954 rs170766 chr17:41963407 C/G cg26893861 chr17:41843967 DUSP3 -0.52 -6.29 -0.33 1e-9 Cognitive function; LUSC cis rs10887741 0.646 rs1358864 chr10:89426630 A/C cg13926569 chr10:89418898 PAPSS2 0.32 6.72 0.35 7.85e-11 Exercise (leisure time); LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.69 0.6 3.61e-34 Platelet count; LUSC cis rs6570726 0.902 rs973855 chr6:145781850 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -12.33 -0.56 4.89e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.17 -0.49 2.38e-21 Obesity-related traits; LUSC cis rs5009270 0.512 rs1024410 chr7:112247542 A/T cg23628563 chr7:112262597 NA 0.43 5.97 0.31 6.01e-9 Osteoarthritis (hip); LUSC cis rs460214 0.576 rs2836604 chr21:40041295 A/C cg12884169 chr21:40033163 ERG -0.35 -5.68 -0.3 2.96e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg04756594 chr16:24857601 SLC5A11 -0.5 -7.42 -0.38 9.8e-13 Intelligence (multi-trait analysis); LUSC cis rs11039100 1.000 rs11039100 chr11:5827003 C/T cg05234568 chr11:5960015 NA 0.52 5.87 0.31 1.07e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7107174 1.000 rs58235466 chr11:78030886 T/C cg02023728 chr11:77925099 USP35 0.45 6.83 0.35 3.99e-11 Testicular germ cell tumor; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg26354017 chr1:205819088 PM20D1 0.84 15.23 0.64 3.78e-40 Menarche (age at onset); LUSC cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.26 0.37 2.77e-12 Motion sickness; LUSC cis rs7481584 0.624 rs412149 chr11:3069943 G/A cg25174290 chr11:3078921 CARS -0.42 -6.19 -0.32 1.75e-9 Calcium levels; LUSC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg15445000 chr17:37608096 MED1 0.39 6.62 0.34 1.44e-10 Glomerular filtration rate (creatinine); LUSC cis rs4642101 0.561 rs7641959 chr3:12810755 G/C cg24848339 chr3:12840334 CAND2 0.33 6.41 0.33 4.95e-10 QRS complex (12-leadsum); LUSC cis rs2235649 0.753 rs7200472 chr16:1849669 T/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.01 -0.31 4.89e-9 Blood metabolite levels; LUSC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.32 0.33 8.29e-10 Menopause (age at onset); LUSC cis rs4555082 0.874 rs56263609 chr14:105756944 C/T cg06808227 chr14:105710500 BRF1 -0.6 -8.4 -0.42 1.26e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs4919694 1.000 rs17727044 chr10:104821256 A/T cg04362960 chr10:104952993 NT5C2 1.2 14.03 0.61 1.84e-35 Arsenic metabolism; LUSC cis rs9902453 0.817 rs2729435 chr17:28121532 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -9.64 -0.47 1.45e-19 Coffee consumption (cups per day); LUSC cis rs3790645 1.000 rs396997 chr1:26893067 T/C cg17456097 chr1:26900765 RPS6KA1 0.42 6.03 0.31 4.23e-9 Glucose homeostasis traits; LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs17253792 0.915 rs77161327 chr14:56178565 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg13891659 chr6:170190454 C6orf122;C6orf208 0.56 7.78 0.39 8.98e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs9549367 0.737 rs11619691 chr13:113904636 T/C cg00898013 chr13:113819073 PROZ -0.57 -8.06 -0.4 1.38e-14 Platelet distribution width; LUSC cis rs11971779 0.680 rs1862879 chr7:139019951 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.22 0.32 1.45e-9 Diisocyanate-induced asthma; LUSC cis rs7106204 0.514 rs7118022 chr11:24253352 C/T ch.11.24196551F chr11:24239977 NA 0.92 10.2 0.49 1.98e-21 Response to Homoharringtonine (cytotoxicity); LUSC trans rs61931739 0.817 rs304313 chr12:34216898 C/T cg13010199 chr12:38710504 ALG10B 0.39 6.26 0.32 1.2e-9 Morning vs. evening chronotype; LUSC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.9 -0.35 2.59e-11 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg01579765 chr21:45077557 HSF2BP -0.52 -10.9 -0.51 7.2e-24 Mean corpuscular volume; LUSC cis rs897984 0.762 rs4889604 chr16:30985994 G/T cg02466173 chr16:30829666 NA 0.55 10.88 0.51 8.73e-24 Dementia with Lewy bodies; LUSC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.24 0.41 3.84e-15 Melanoma; LUSC cis rs9467773 1.000 rs1884946 chr6:26545308 C/G cg11502198 chr6:26597334 ABT1 0.59 9.38 0.46 1.06e-18 Intelligence (multi-trait analysis); LUSC trans rs2562456 0.520 rs250001 chr19:21408189 A/G cg00806126 chr19:22604979 ZNF98 -0.43 -6.06 -0.31 3.64e-9 Pain; LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg16145915 chr7:1198662 ZFAND2A -0.76 -17.37 -0.69 1.31e-48 Longevity;Endometriosis; LUSC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg07936489 chr17:37558343 FBXL20 0.71 9.74 0.47 6.96e-20 Glomerular filtration rate (creatinine); LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.87 -12.65 -0.57 3.21e-30 Alzheimer's disease; LUSC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg25258033 chr6:167368657 RNASET2 -0.49 -8.17 -0.41 6.37e-15 Lung cancer; LUSC cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.85 -0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg07701084 chr6:150067640 NUP43 0.57 8.71 0.43 1.47e-16 Lung cancer; LUSC cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.04 -0.44 1.25e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg09034736 chr1:150693464 HORMAD1 -0.48 -7.02 -0.36 1.22e-11 Tonsillectomy; LUSC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg11062466 chr8:58055876 NA 0.52 6.76 0.35 6.25e-11 Developmental language disorder (linguistic errors); LUSC cis rs478304 0.934 rs517115 chr11:65526988 C/T cg05805236 chr11:65401703 PCNXL3 0.4 6.84 0.35 3.82e-11 Acne (severe); LUSC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg03233332 chr7:66118400 NA 0.42 6.07 0.32 3.46e-9 Aortic root size; LUSC cis rs7043114 0.525 rs10116241 chr9:95240546 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.33 -0.33 8.05e-10 Height; LUSC cis rs7084921 0.608 rs11597390 chr10:101861435 A/G cg02250046 chr10:101825185 CPN1 0.35 6.39 0.33 5.64e-10 Bone mineral density; LUSC cis rs11583043 0.575 rs12727971 chr1:101589175 A/G cg11406453 chr1:101602562 NA -0.4 -6.64 -0.34 1.24e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs911119 0.955 rs8115417 chr20:23605223 T/A cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs72781680 0.699 rs72794291 chr2:23897935 C/T cg20701182 chr2:24300061 SF3B14 0.75 7.32 0.37 1.87e-12 Lymphocyte counts; LUSC trans rs1864585 0.520 rs17776622 chr8:10676497 T/C cg26278703 chr11:58910052 FAM111A 0.54 6.13 0.32 2.53e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.84 -0.3 1.23e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg03354898 chr7:1950403 MAD1L1 -0.42 -8.43 -0.42 1.02e-15 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg18404041 chr3:52824283 ITIH1 -0.6 -11.57 -0.53 3.03e-26 Bipolar disorder; LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs7241530 0.662 rs55752151 chr18:75901986 T/C cg14642773 chr18:75888474 NA 0.41 6.27 0.32 1.14e-9 Educational attainment (years of education); LUSC cis rs722599 0.748 rs55707505 chr14:75362552 T/C cg06637938 chr14:75390232 RPS6KL1 -0.42 -6.19 -0.32 1.81e-9 IgG glycosylation; LUSC cis rs7586879 0.861 rs10164466 chr2:25114069 T/C cg01884057 chr2:25150051 NA 0.43 8.98 0.44 1.98e-17 Body mass index; LUSC cis rs4845570 0.920 rs1521185 chr1:151764049 A/G cg07092448 chr1:151763213 TDRKH 1.26 16.49 0.67 4.2e-45 Coronary artery disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15234297 chr19:50143472 RRAS -0.43 -6.39 -0.33 5.42e-10 Electrocardiographic conduction measures; LUSC cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg11244672 chr19:19639970 YJEFN3 -0.53 -6.65 -0.34 1.19e-10 Bipolar disorder; LUSC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11890956 chr21:40555474 PSMG1 1.03 20.65 0.75 1.23e-61 Cognitive function; LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg12564285 chr5:131593104 PDLIM4 0.5 9.02 0.44 1.47e-17 Acylcarnitine levels; LUSC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.13 -0.36 6.24e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg03709012 chr19:19516395 GATAD2A 0.84 14.34 0.62 1.1e-36 Tonsillectomy; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg00814883 chr7:100076585 TSC22D4 -0.67 -8.18 -0.41 6.08e-15 Platelet count; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg08888203 chr3:10149979 C3orf24 -0.66 -7.91 -0.4 3.8e-14 Alzheimer's disease; LUSC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg14019146 chr3:50243930 SLC38A3 0.32 7.05 0.36 1.04e-11 Intelligence (multi-trait analysis); LUSC cis rs6580649 0.657 rs57863747 chr12:48470425 G/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs35883536 0.626 rs34752753 chr1:101045193 T/G cg06223162 chr1:101003688 GPR88 -0.48 -9.01 -0.44 1.6e-17 Monocyte count; LUSC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg17252645 chr8:143867129 LY6D 0.38 6.67 0.34 1.06e-10 Urinary tract infection frequency; LUSC cis rs1008375 0.931 rs7435102 chr4:17571480 C/G cg18681998 chr4:17616180 MED28 0.83 14.53 0.62 2.08e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg18876405 chr7:65276391 NA -0.71 -12.7 -0.57 2.07e-30 Aortic root size; LUSC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg00152838 chr16:24741724 TNRC6A 0.48 6.11 0.32 2.71e-9 Intelligence (multi-trait analysis); LUSC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.92 0.4 3.53e-14 Bipolar disorder; LUSC cis rs7923609 1.000 rs10822163 chr10:65124098 C/G cg01631684 chr10:65280961 REEP3 -0.38 -5.93 -0.31 7.44e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs1322512 0.760 rs2758806 chr6:152960141 A/G cg27316956 chr6:152958899 SYNE1 -0.38 -6.33 -0.33 7.73e-10 Tonometry; LUSC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.58 0.5 9.76e-23 Schizophrenia; LUSC cis rs477692 0.870 rs512655 chr10:131424547 T/A cg26102564 chr10:131424627 MGMT 0.37 5.79 0.3 1.59e-8 Response to temozolomide; LUSC cis rs30380 0.587 rs469674 chr5:96130015 G/C cg16492584 chr5:96139282 ERAP1 -0.53 -7.2 -0.37 4.07e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg17420585 chr12:42539391 GXYLT1 -0.37 -7.01 -0.36 1.31e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7106204 0.514 rs1443044 chr11:24255575 C/G ch.11.24196551F chr11:24239977 NA -0.89 -10.16 -0.49 2.59e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10484885 0.824 rs11967579 chr6:90540008 G/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -7.99 -0.4 2.26e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs11958404 0.932 rs72816563 chr5:157427447 C/T cg05962755 chr5:157440814 NA 0.52 6.22 0.32 1.52e-9 IgG glycosylation; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg00684032 chr4:1343700 KIAA1530 -0.38 -6.52 -0.34 2.66e-10 Obesity-related traits; LUSC cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.66 -0.3 3.23e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs564343 0.563 rs570760 chr11:65833631 C/T cg26701943 chr11:108369231 KDELC2 -0.45 -6.25 -0.32 1.28e-9 Obesity (early onset extreme); LUSC cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.93 -0.35 2.24e-11 Body mass index; LUSC cis rs1843834 1.000 rs4624372 chr2:225553128 A/G cg22455342 chr2:225449267 CUL3 0.46 6.16 0.32 2.14e-9 IgE levels in asthmatics (D.p. specific); LUSC trans rs11992162 0.573 rs13275808 chr8:11782815 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.41 -0.33 5.05e-10 Monocyte count; LUSC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.43 0.5 3.19e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2455601 0.786 rs3751064 chr11:8958903 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -7.35 -0.37 1.58e-12 Schizophrenia; LUSC cis rs12210905 0.688 rs12374607 chr6:27343620 A/G cg08851530 chr6:28072375 NA 0.9 5.78 0.3 1.75e-8 Hip circumference adjusted for BMI; LUSC trans rs1728785 1.000 rs1728773 chr16:68563644 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.35 0.53 1.8e-25 Alzheimer's disease; LUSC cis rs9467711 0.517 rs16901784 chr6:26555433 C/A cg09904177 chr6:26538194 HMGN4 -0.72 -6.68 -0.34 1e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.34 0.56 4.44e-29 Prudent dietary pattern; LUSC cis rs9393777 0.778 rs35741362 chr6:27007687 T/C cg26958806 chr6:27640298 NA 0.59 5.79 0.3 1.63e-8 Intelligence (multi-trait analysis); LUSC cis rs9325144 0.600 rs10880934 chr12:38730455 C/T cg26384229 chr12:38710491 ALG10B -0.6 -9.29 -0.45 2.04e-18 Morning vs. evening chronotype; LUSC cis rs977987 0.645 rs10871311 chr16:75450912 T/A cg03315344 chr16:75512273 CHST6 0.48 8.91 0.44 3.28e-17 Dupuytren's disease; LUSC cis rs4919087 0.962 rs10748691 chr10:98983955 C/T cg25902810 chr10:99078978 FRAT1 0.53 7.42 0.38 9.65e-13 Monocyte count; LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg10729496 chr3:10149963 C3orf24 0.58 7.68 0.39 1.75e-13 Alzheimer's disease; LUSC cis rs9467773 0.620 rs1027203 chr6:26639332 G/C cg05738196 chr6:26577821 NA 0.78 14.76 0.63 2.72e-38 Intelligence (multi-trait analysis); LUSC cis rs4319547 0.695 rs11836188 chr12:122865507 T/C cg23029597 chr12:123009494 RSRC2 0.74 9.36 0.46 1.24e-18 Body mass index; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs2067615 0.579 rs4964486 chr12:107140790 A/G cg15890332 chr12:107067104 RFX4 0.34 6.27 0.32 1.1e-9 Heart rate; LUSC cis rs9463078 0.547 rs116177834 chr6:44738548 C/A cg25276700 chr6:44698697 NA 0.3 6.3 0.33 9.28e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg08888203 chr3:10149979 C3orf24 0.66 9.33 0.45 1.48e-18 Alzheimer's disease; LUSC cis rs8014204 0.762 rs12889665 chr14:75234830 T/G cg06637938 chr14:75390232 RPS6KL1 0.51 8.01 0.4 1.95e-14 Caffeine consumption; LUSC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg07414643 chr4:187882934 NA 0.57 10.82 0.51 1.36e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs735539 0.645 rs6490600 chr13:21208189 G/T cg04906043 chr13:21280425 IL17D -0.43 -6.83 -0.35 4.07e-11 Dental caries; LUSC trans rs8072100 0.840 rs4968319 chr17:45464967 A/G cg03886242 chr7:26192032 NFE2L3 -0.38 -6.34 -0.33 7.31e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs76878669 0.561 rs7125752 chr11:66162419 C/T cg24851651 chr11:66362959 CCS 0.37 5.86 0.31 1.08e-8 Educational attainment (years of education); LUSC cis rs881375 0.933 rs7021206 chr9:123684157 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.36 -5.99 -0.31 5.53e-9 Rheumatoid arthritis; LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg13282195 chr8:144660772 NAPRT1 -0.68 -7.77 -0.39 9.81e-14 Attention deficit hyperactivity disorder; LUSC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg01802117 chr1:53393560 SCP2 0.39 6.41 0.33 5.03e-10 Monocyte count; LUSC cis rs6714710 0.580 rs11692470 chr2:98520564 T/C cg26665480 chr2:98280029 ACTR1B 0.61 8.9 0.44 3.72e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1801251 1.000 rs6747645 chr2:233571033 C/T cg25237894 chr2:233734115 C2orf82 -0.34 -6.35 -0.33 6.91e-10 Coronary artery disease; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg16405210 chr4:1374714 KIAA1530 -0.52 -8.13 -0.41 8.57e-15 Obesity-related traits; LUSC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg00814883 chr7:100076585 TSC22D4 -0.75 -10.28 -0.49 9.98e-22 Platelet count; LUSC cis rs1009647 0.656 rs10147254 chr14:55850315 C/A cg04306507 chr14:55594613 LGALS3 0.48 9.5 0.46 4.36e-19 Testicular germ cell tumor; LUSC cis rs887829 0.569 rs4124874 chr2:234665659 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -7.33 -0.37 1.77e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs11105298 0.891 rs10858864 chr12:89846230 C/T cg00757033 chr12:89920650 WDR51B 0.59 10.19 0.49 2.14e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs11098499 0.955 rs13114751 chr4:120156617 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC cis rs600231 0.719 rs7114809 chr11:65251444 A/G cg21890820 chr11:65308645 LTBP3 0.5 7.38 0.37 1.27e-12 Bone mineral density; LUSC trans rs877282 0.755 rs2790388 chr10:786084 T/C cg22713356 chr15:30763199 NA 0.89 12.81 0.57 8e-31 Uric acid levels; LUSC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg03684893 chr10:554711 DIP2C -0.37 -6.67 -0.34 1.07e-10 Psychosis in Alzheimer's disease; LUSC cis rs2235649 0.833 rs9939694 chr16:1852760 C/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.44 -6.02 -0.31 4.57e-9 Blood metabolite levels; LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg14092988 chr3:52407081 DNAH1 0.3 5.92 0.31 7.78e-9 Bipolar disorder; LUSC cis rs12545109 0.800 rs1992122 chr8:57409467 A/G cg09654669 chr8:57350985 NA -0.58 -7.79 -0.39 8.28e-14 Obesity-related traits; LUSC cis rs4566357 0.615 rs4350744 chr2:227918146 A/T cg11843606 chr2:227700838 RHBDD1 -0.53 -8.13 -0.41 8.57e-15 Coronary artery disease; LUSC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg06636001 chr8:8085503 FLJ10661 0.69 11.54 0.53 3.78e-26 Mood instability; LUSC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg00339695 chr16:24857497 SLC5A11 -0.61 -9.61 -0.47 1.76e-19 Intelligence (multi-trait analysis); LUSC cis rs6665290 0.904 rs3768425 chr1:227178127 A/G cg10327440 chr1:227177885 CDC42BPA -1.21 -40.51 -0.91 6.17e-131 Myeloid white cell count; LUSC cis rs79839061 0.610 rs62297062 chr4:869698 C/T cg14530993 chr4:882597 GAK 0.72 7.42 0.38 1e-12 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.747 rs1415959 chr1:152973690 C/T cg25856811 chr1:152973957 SPRR3 0.34 5.78 0.3 1.67e-8 Inflammatory skin disease; LUSC cis rs7772486 0.875 rs2814871 chr6:146312274 G/T cg23711669 chr6:146136114 FBXO30 0.85 15.09 0.64 1.38e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs7945718 0.935 rs11022501 chr11:12809314 T/C cg25843174 chr11:12811716 TEAD1 0.34 7.61 0.38 2.9e-13 Educational attainment (years of education); LUSC cis rs11169552 0.510 rs10876063 chr12:50972085 C/T cg12884762 chr12:50931848 DIP2B -0.32 -5.67 -0.3 3.11e-8 Colorectal cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21086891 chr3:192635035 C3orf59 0.45 6.4 0.33 5.22e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9462027 0.628 rs7774697 chr6:34791027 C/T cg07306190 chr6:34760872 UHRF1BP1 0.32 5.65 0.3 3.45e-8 Systemic lupus erythematosus; LUSC cis rs701145 0.585 rs1713798 chr3:153807407 G/A cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs7786877 0.521 rs2293767 chr7:100361675 A/G cg20848291 chr7:100343083 ZAN 0.4 6.08 0.32 3.24e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg11266682 chr4:10021025 SLC2A9 0.49 9.19 0.45 4.39e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs61931739 1.000 rs12427391 chr12:34022891 A/G cg13010199 chr12:38710504 ALG10B -0.4 -6.05 -0.31 3.99e-9 Morning vs. evening chronotype; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg11965913 chr1:205819406 PM20D1 0.96 20.06 0.74 2.79e-59 Menarche (age at onset); LUSC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg14830002 chr1:247616686 OR2B11 0.49 7.05 0.36 1.05e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs10761482 0.861 rs719095 chr10:62110949 T/G cg18175470 chr10:62150864 ANK3 -0.5 -7.01 -0.36 1.36e-11 Schizophrenia; LUSC cis rs9303401 0.661 rs9902820 chr17:56637545 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.52 8.2 0.41 5.37e-15 Cognitive test performance; LUSC cis rs2486288 0.656 rs12911186 chr15:45551423 A/G cg09092052 chr15:45571596 NA 0.45 6.26 0.32 1.18e-9 Glomerular filtration rate; LUSC cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -5.95 -0.31 6.64e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs4820792 1.000 rs4820792 chr22:29161007 C/T cg22827864 chr6:72298424 NA -0.47 -6.31 -0.33 9.11e-10 Breast size; LUSC cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.64 -0.43 2.43e-16 Schizophrenia; LUSC cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg13319975 chr6:146136371 FBXO30 0.49 7.48 0.38 6.77e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg12463550 chr7:65579703 CRCP 0.45 6.76 0.35 6.2e-11 Aortic root size; LUSC cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg11584989 chr19:19387371 SF4 0.57 6.82 0.35 4.18e-11 Bipolar disorder; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.82 0.78 3.9e-70 Prudent dietary pattern; LUSC trans rs13390641 0.614 rs72818308 chr2:104082460 A/T cg03260781 chr1:16346299 HSPB7 -0.46 -6.09 -0.32 3.14e-9 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs9902453 0.808 rs76039587 chr17:28233760 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 10.05 0.48 6.26e-21 Coffee consumption (cups per day); LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg03790207 chr6:42947109 PEX6 -0.45 -6.83 -0.35 4.01e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.12 0.55 2.92e-28 Motion sickness; LUSC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.65 0.47 1.38e-19 Bipolar disorder; LUSC cis rs7937682 0.855 rs10891285 chr11:111527775 T/C cg19812747 chr11:111475976 SIK2 -0.49 -7.0 -0.36 1.4e-11 Primary sclerosing cholangitis; LUSC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg18876405 chr7:65276391 NA -0.66 -11.6 -0.54 2.26e-26 Aortic root size; LUSC cis rs11785400 0.793 rs7000765 chr8:143722457 G/A cg10596483 chr8:143751796 JRK 0.51 7.31 0.37 1.94e-12 Schizophrenia; LUSC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg16647868 chr5:131706066 SLC22A5 -0.34 -5.72 -0.3 2.36e-8 Blood metabolite levels; LUSC cis rs6546550 0.901 rs10496174 chr2:70153436 T/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.31 -0.37 1.98e-12 Prevalent atrial fibrillation; LUSC cis rs7909074 1.000 rs12777258 chr10:45394961 A/G cg05187965 chr10:45406764 TMEM72 0.39 9.01 0.44 1.62e-17 Mean corpuscular volume; LUSC cis rs9467711 0.606 rs35076545 chr6:26603924 C/A cg09904177 chr6:26538194 HMGN4 -0.75 -5.79 -0.3 1.63e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg15839431 chr19:19639596 YJEFN3 -0.42 -5.89 -0.31 9.46e-9 Tonsillectomy; LUSC cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg18196295 chr10:418757 DIP2C 0.48 7.37 0.37 1.33e-12 Psychosis in Alzheimer's disease; LUSC trans rs208520 0.739 rs1935894 chr6:66891434 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -15.38 -0.64 9.97e-41 Exhaled nitric oxide output; LUSC cis rs7824557 0.564 rs2736293 chr8:11234613 T/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.89 -0.31 9.23e-9 Retinal vascular caliber; LUSC cis rs9815354 0.761 rs12186051 chr3:41836919 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg21862992 chr11:68658383 NA 0.51 8.4 0.42 1.34e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6138458 0.962 rs6036976 chr20:24901567 T/G cg26195577 chr20:24973756 C20orf3 -1.12 -18.25 -0.71 4.21e-52 Blood protein levels; LUSC trans rs877282 0.898 rs12358513 chr10:757571 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.51 -0.34 2.71e-10 Uric acid levels; LUSC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg17252645 chr8:143867129 LY6D 0.37 6.58 0.34 1.77e-10 Urinary tract infection frequency; LUSC trans rs61931739 0.890 rs1197560 chr12:34121447 G/C cg24313572 chr1:56050060 NA -0.29 -5.96 -0.31 6.34e-9 Morning vs. evening chronotype; LUSC cis rs72781680 0.752 rs56343114 chr2:23900629 C/G cg20701182 chr2:24300061 SF3B14 0.57 5.84 0.3 1.23e-8 Lymphocyte counts; LUSC cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg05343316 chr1:45956843 TESK2 0.72 9.81 0.47 4.02e-20 Platelet count; LUSC cis rs10193935 0.792 rs2053349 chr2:42516205 G/A cg27598129 chr2:42591480 NA -0.58 -8.03 -0.4 1.72e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9467773 1.000 rs6940188 chr6:26562029 G/C cg11502198 chr6:26597334 ABT1 0.63 9.95 0.48 1.3e-20 Intelligence (multi-trait analysis); LUSC cis rs887829 0.569 rs3755319 chr2:234667582 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.41 -6.8 -0.35 4.7e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs4631830 0.828 rs10763567 chr10:51538169 C/A cg16070123 chr10:51489643 NA 0.47 7.38 0.37 1.25e-12 Prostate-specific antigen levels; LUSC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.42 -0.53 9.82e-26 Mean corpuscular volume; LUSC cis rs11625487 0.609 rs45493395 chr14:77976468 T/C cg16049707 chr14:77965284 ISM2 -0.61 -6.55 -0.34 2.12e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs28830936 1.000 rs28830936 chr15:41906408 G/A cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.31 -0.33 8.69e-10 Diastolic blood pressure; LUSC trans rs1908814 0.503 rs34657250 chr8:11795373 A/G cg15556689 chr8:8085844 FLJ10661 -0.59 -8.96 -0.44 2.42e-17 Neuroticism; LUSC cis rs6967385 0.560 rs55794302 chr7:12351495 C/A cg06484146 chr7:12443880 VWDE 0.49 7.34 0.37 1.63e-12 Response to taxane treatment (placlitaxel); LUSC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg10053473 chr17:62856997 LRRC37A3 0.65 10.27 0.49 1.13e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6964587 1.000 rs6942649 chr7:91594510 A/G cg17063962 chr7:91808500 NA 0.42 6.78 0.35 5.35e-11 Breast cancer; LUSC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg06637938 chr14:75390232 RPS6KL1 -0.53 -8.39 -0.42 1.43e-15 Height; LUSC cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg26384229 chr12:38710491 ALG10B 0.96 18.39 0.71 1.14e-52 Heart rate; LUSC trans rs1493916 0.592 rs1389068 chr18:31312738 G/T cg27147174 chr7:100797783 AP1S1 -0.45 -6.91 -0.35 2.4e-11 Life satisfaction; LUSC cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -12.22 -0.56 1.23e-28 Chronic sinus infection; LUSC cis rs61931739 0.500 rs10772163 chr12:34532950 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg11366901 chr6:160182831 ACAT2 0.91 12.35 0.56 3.99e-29 Age-related macular degeneration (geographic atrophy); LUSC cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.53e-9 Breast cancer; LUSC trans rs1038903 0.849 rs1038905 chr4:28739878 C/T cg08616269 chr10:70480892 CCAR1 0.49 6.0 0.31 5.16e-9 Menarche (age at onset); LUSC cis rs6460942 0.591 rs62448733 chr7:12350526 C/T cg06484146 chr7:12443880 VWDE -0.59 -6.28 -0.32 1.05e-9 Coronary artery disease; LUSC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg17330251 chr7:94953956 PON1 -0.37 -5.99 -0.31 5.57e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.57 0.38 3.58e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs2073300 1.000 rs12625999 chr20:23442085 A/G cg09953122 chr20:23471693 CST8 0.87 7.32 0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6012953 0.874 rs1885177 chr20:49191228 A/C cg13958625 chr20:49123093 NA -0.27 -5.94 -0.31 7.2e-9 Vitiligo; LUSC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.58 8.56 0.42 4.29e-16 IgG glycosylation; LUSC cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg21573476 chr21:45109991 RRP1B -0.4 -6.66 -0.34 1.11e-10 Mean corpuscular volume; LUSC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg00343986 chr7:65444356 GUSB 0.45 6.92 0.35 2.33e-11 Aortic root size; LUSC cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg06484146 chr7:12443880 VWDE -0.62 -6.24 -0.32 1.36e-9 Coronary artery disease; LUSC cis rs7011049 1.000 rs11997538 chr8:53832663 A/C cg26025543 chr8:53854495 NA 0.48 5.97 0.31 6.03e-9 Systolic blood pressure; LUSC cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg06784218 chr1:46089804 CCDC17 -0.51 -9.84 -0.47 3.24e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9303401 0.659 rs62081315 chr17:56781468 T/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs6084875 0.840 rs2422934 chr20:4720146 G/A cg26097573 chr20:4721490 PRNT -0.31 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs9837602 1.000 rs6799379 chr3:99762840 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 6.17 0.32 2.01e-9 Breast cancer; LUSC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg03351412 chr1:154909251 PMVK 0.49 7.48 0.38 6.69e-13 Prostate cancer; LUSC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08109568 chr15:31115862 NA -0.57 -7.95 -0.4 2.99e-14 Huntington's disease progression; LUSC trans rs7937682 0.558 rs7113067 chr11:111692182 G/A cg18187862 chr3:45730750 SACM1L -0.52 -6.32 -0.33 8.33e-10 Primary sclerosing cholangitis; LUSC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg00484396 chr16:3507460 NAT15 -0.91 -10.62 -0.5 6.98e-23 Tuberculosis; LUSC cis rs8060686 0.545 rs17688076 chr16:68286427 C/A cg27539214 chr16:67997921 SLC12A4 -0.59 -7.0 -0.36 1.44e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs12681288 0.792 rs4735972 chr8:998618 A/C cg15309053 chr8:964076 NA 0.3 6.3 0.33 9.24e-10 Schizophrenia; LUSC cis rs61931739 0.500 rs1601628 chr12:34047375 A/C cg06521331 chr12:34319734 NA -0.51 -8.37 -0.42 1.55e-15 Morning vs. evening chronotype; LUSC cis rs4604732 0.536 rs76191272 chr1:247628055 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.78 0.35 5.42e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7605827 0.857 rs10185835 chr2:15495763 A/G cg19274914 chr2:15703543 NA 0.44 8.54 0.42 4.75e-16 Educational attainment (years of education); LUSC trans rs236907 0.859 rs7522582 chr1:171770111 G/C cg13482142 chr2:234261155 NA 0.5 6.16 0.32 2.07e-9 Mean platelet volume; LUSC cis rs1267303 1.000 rs1267303 chr1:46990457 A/G cg25110126 chr1:46999211 NA 0.51 7.74 0.39 1.17e-13 Monobrow; LUSC cis rs9653442 0.564 rs12712071 chr2:100793876 G/A cg07810366 chr2:100720526 AFF3 -0.45 -7.64 -0.39 2.34e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg09877947 chr5:131593287 PDLIM4 0.37 6.0 0.31 5.04e-9 Breast cancer;Mosquito bite size; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg01287788 chr2:86362935 SNORD94;PTCD3 0.48 7.53 0.38 4.81e-13 Cognitive function;Information processing speed; LUSC cis rs983392 0.709 rs1820428 chr11:59986333 A/T cg02771260 chr11:59836817 MS4A3 -0.36 -5.93 -0.31 7.71e-9 Alzheimer's disease (late onset); LUSC trans rs561341 0.714 rs75861674 chr17:30304317 A/G cg27661571 chr11:113659931 NA -0.6 -7.29 -0.37 2.25e-12 Hip circumference adjusted for BMI; LUSC cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg08085267 chr17:45401833 C17orf57 0.45 6.63 0.34 1.36e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7605827 0.930 rs4668921 chr2:15672071 T/C cg19274914 chr2:15703543 NA 0.46 8.81 0.43 7.12e-17 Educational attainment (years of education); LUSC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.66 -0.3 3.31e-8 Life satisfaction; LUSC cis rs478304 0.817 rs524475 chr11:65518065 T/A cg08755490 chr11:65554678 OVOL1 0.41 5.87 0.31 1.05e-8 Acne (severe); LUSC trans rs4718428 0.705 rs28648401 chr7:66367132 T/C cg18876405 chr7:65276391 NA 0.49 6.64 0.34 1.24e-10 Corneal structure; LUSC cis rs7647973 0.925 rs4955421 chr3:49218888 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.47 6.98 0.36 1.58e-11 Menarche (age at onset); LUSC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg17173187 chr15:85201210 NMB 0.37 6.57 0.34 1.96e-10 Schizophrenia; LUSC cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.47 0.38 7.01e-13 Motion sickness; LUSC trans rs7567288 0.636 rs6726369 chr2:134464994 G/A cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC cis rs7481584 0.669 rs12793371 chr11:3034709 A/G cg08508325 chr11:3079039 CARS 0.35 7.65 0.39 2.1e-13 Calcium levels; LUSC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.34 -0.42 1.91e-15 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04334417 chr11:32112457 RCN1 -0.43 -6.39 -0.33 5.44e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg20203395 chr5:56204925 C5orf35 0.77 10.05 0.48 6.16e-21 Initial pursuit acceleration; LUSC cis rs5758511 0.680 rs5758667 chr22:42633204 G/A cg00645731 chr22:42541494 CYP2D7P1 0.57 10.0 0.48 8.88e-21 Birth weight; LUSC trans rs11098499 0.866 rs13125526 chr4:120288019 G/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg05368731 chr17:41323189 NBR1 0.83 13.98 0.61 2.73e-35 Menopause (age at onset); LUSC cis rs10484885 0.878 rs72921916 chr6:90555990 C/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.04 -0.4 1.6e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 14.01 0.61 2.15e-35 Platelet count; LUSC cis rs7246657 0.551 rs4806414 chr19:37638788 T/C cg23950597 chr19:37808831 NA -0.56 -5.81 -0.3 1.46e-8 Coronary artery calcification; LUSC cis rs7712401 0.592 rs154515 chr5:122191145 G/T cg19077854 chr5:122220652 SNX24 0.35 8.11 0.41 9.49e-15 Mean platelet volume; LUSC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.45 7.12 0.36 6.81e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg12011299 chr4:100065546 ADH4 -0.73 -11.31 -0.53 2.45e-25 Alcohol dependence; LUSC cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg02228329 chr11:64053129 BAD;GPR137 0.44 6.23 0.32 1.37e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg18876405 chr7:65276391 NA -0.55 -8.76 -0.43 9.78e-17 Aortic root size; LUSC cis rs16854884 0.633 rs6779321 chr3:143736676 T/C cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs9611565 0.921 rs2235846 chr22:41741042 G/C cg03806693 chr22:41940476 POLR3H -0.74 -10.94 -0.51 5.05e-24 Vitiligo; LUSC cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg20701182 chr2:24300061 SF3B14 0.46 5.64 0.3 3.55e-8 Asthma; LUSC cis rs2742540 0.503 rs7106539 chr11:8897533 T/G cg12365402 chr11:9010492 NRIP3 -0.46 -8.17 -0.41 6.36e-15 Hematocrit; LUSC cis rs11608355 0.515 rs11614551 chr12:109931630 G/A cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.02 -0.31 4.65e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs131777 0.576 rs131758 chr22:51017082 T/A cg00047287 chr22:51016899 CPT1B;CHKB-CPT1B 0.36 5.96 0.31 6.32e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg21545522 chr1:205238299 TMCC2 0.49 9.47 0.46 5.26e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg05347473 chr6:146136440 FBXO30 -0.59 -10.46 -0.5 2.46e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs9549367 0.789 rs9549361 chr13:113898329 C/T cg18105134 chr13:113819100 PROZ 0.59 8.39 0.42 1.36e-15 Platelet distribution width; LUSC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg11663144 chr21:46675770 NA -0.42 -7.57 -0.38 3.72e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10170310 1.000 rs12691947 chr2:139264471 A/G cg10095539 chr2:139258744 SPOPL 0.33 5.89 0.31 9.45e-9 Response to antipsychotic treatment; LUSC cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -8.78 -0.43 8.67e-17 Bone mineral density; LUSC cis rs7538876 0.903 rs730153 chr1:17749504 A/G cg07965774 chr1:17746286 RCC2 -0.33 -6.22 -0.32 1.46e-9 Basal cell carcinoma; LUSC cis rs11039100 0.850 rs12363853 chr11:5830163 G/A cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg05855489 chr10:104503620 C10orf26 -0.57 -7.6 -0.38 2.98e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 7.12 0.36 6.66e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11758351 0.715 rs76130408 chr6:26208962 A/G cg23601095 chr6:26197514 HIST1H3D 0.7 7.44 0.38 8.35e-13 Gout;Renal underexcretion gout; LUSC cis rs12136530 0.774 rs12409301 chr1:19774715 G/A cg01832549 chr1:19774989 CAPZB -0.32 -5.94 -0.31 7.33e-9 Lead levels in blood; LUSC cis rs4253772 0.550 rs9615347 chr22:46728153 A/G cg09491104 chr22:46646882 C22orf40 -0.71 -7.03 -0.36 1.13e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs5758511 0.573 rs1569451 chr22:42232291 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.39 -7.52 -0.38 5.01e-13 Birth weight; LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg04267008 chr7:1944627 MAD1L1 -0.59 -8.93 -0.44 2.88e-17 Bipolar disorder and schizophrenia; LUSC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.83 -0.3 1.32e-8 Tonsillectomy; LUSC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg01842473 chr11:617407 IRF7;MUPCDH -0.6 -8.27 -0.41 3.19e-15 Systemic lupus erythematosus; LUSC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg24399712 chr22:39784796 NA -0.64 -11.92 -0.55 1.53e-27 Intelligence (multi-trait analysis); LUSC trans rs17685 0.725 rs4728548 chr7:75654632 A/T cg19862616 chr7:65841803 NCRNA00174 -0.99 -15.41 -0.64 7.63e-41 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.54 -0.38 4.33e-13 Blood metabolite levels; LUSC trans rs62103177 0.513 rs9945153 chr18:77598450 C/T cg14227996 chr4:17616232 MED28 0.77 7.8 0.39 8.18e-14 Opioid sensitivity; LUSC cis rs2717559 0.561 rs7841267 chr8:143881683 A/C cg07661805 chr8:143867942 LY6D -0.26 -6.08 -0.32 3.25e-9 Urinary tract infection frequency; LUSC cis rs8060686 0.641 rs12447931 chr16:68179195 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.39 -0.33 5.51e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs433852 0.904 rs8102492 chr19:49140809 A/C cg06530960 chr19:49140787 SEC1;DBP 0.73 9.29 0.45 2.05e-18 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs3540 0.574 rs2256388 chr15:90969335 A/C cg22089800 chr15:90895588 ZNF774 -0.6 -9.17 -0.45 4.87e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.68 0.43 1.82e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs6088590 0.748 rs6142206 chr20:33212055 G/A cg24642439 chr20:33292090 TP53INP2 0.59 8.73 0.43 1.25e-16 Coronary artery disease; LUSC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg02475777 chr4:1388615 CRIPAK 0.43 6.39 0.33 5.68e-10 Obesity-related traits; LUSC cis rs10740039 0.729 rs6479721 chr10:62373122 A/C cg18175470 chr10:62150864 ANK3 -0.43 -6.45 -0.33 3.87e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4595586 0.545 rs7967931 chr12:39375162 A/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC trans rs61931739 0.534 rs10844840 chr12:34364517 C/T cg26384229 chr12:38710491 ALG10B 0.88 15.02 0.63 2.46e-39 Morning vs. evening chronotype; LUSC cis rs72781680 0.898 rs72782126 chr2:24039901 A/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs1577917 1.000 rs10498958 chr6:86649705 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.45 6.56 0.34 2.01e-10 Response to antipsychotic treatment; LUSC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg12292205 chr6:26970375 C6orf41 -0.58 -7.15 -0.36 5.62e-12 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.643 rs10751671 chr11:944479 T/G ch.11.42038R chr11:967971 AP2A2 0.43 6.42 0.33 4.65e-10 Alzheimer's disease (late onset); LUSC cis rs7267979 1.000 rs6037105 chr20:25374199 C/A cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs711244 0.777 rs12476515 chr2:37102620 T/C cg14987922 chr2:37194071 STRN -0.44 -6.36 -0.33 6.83e-10 Mean platelet volume; LUSC trans rs1927790 0.616 rs1925119 chr13:96939586 C/A cg03198741 chr6:1003969 LOC285768 -0.41 -6.26 -0.32 1.21e-9 Body mass index; LUSC cis rs7572644 0.656 rs4666016 chr2:28037140 T/A cg27432699 chr2:27873401 GPN1 0.58 7.37 0.37 1.36e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg05585544 chr11:47624801 NA -0.33 -6.04 -0.31 4.11e-9 Subjective well-being; LUSC cis rs7147624 0.572 rs2411813 chr14:66023906 G/A cg03016385 chr14:66212404 NA -0.82 -7.76 -0.39 1.02e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7953508 0.506 rs930316 chr12:93967035 A/G cg18151635 chr12:93972918 NA -0.62 -8.96 -0.44 2.35e-17 Pubertal anthropometrics; LUSC cis rs7267979 0.527 rs6083891 chr20:25574272 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.76 -0.57 1.17e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9612 1.000 rs28373139 chr19:44246706 A/G cg08581076 chr19:44259116 C19orf61 0.53 6.57 0.34 1.88e-10 Exhaled nitric oxide output; LUSC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.75 10.73 0.51 2.75e-23 Cognitive test performance; LUSC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg13683864 chr3:40499215 RPL14 -1.14 -21.17 -0.76 1.15e-63 Renal cell carcinoma; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13126279 chr21:47581558 C21orf56 0.54 8.39 0.42 1.41e-15 Testicular germ cell tumor; LUSC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg19468946 chr17:37922297 IKZF3 -0.44 -6.99 -0.36 1.5e-11 Self-reported allergy; LUSC cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg06558623 chr16:89946397 TCF25 0.83 7.39 0.38 1.15e-12 Skin colour saturation; LUSC trans rs89107 0.651 rs2356080 chr6:118609174 G/T cg11574620 chr4:80246899 NAA11 -0.37 -6.1 -0.32 2.94e-9 Cardiac structure and function; LUSC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -7.95 -0.4 2.96e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2731664 0.792 rs335467 chr5:176890642 A/G cg23176889 chr5:176863531 GRK6 -0.71 -14.74 -0.63 3.07e-38 Intelligence (multi-trait analysis); LUSC cis rs748404 0.697 rs530683 chr15:43568999 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.57 -8.93 -0.44 2.8e-17 Lung cancer; LUSC cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.13 0.55 2.73e-28 Colorectal cancer; LUSC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs748404 0.650 rs556851 chr15:43571219 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.56 8.76 0.43 1.03e-16 Lung cancer; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC cis rs7605827 1.000 rs7605827 chr2:15598740 A/T cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.55e-18 Educational attainment (years of education); LUSC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg05084668 chr3:125655381 ALG1L -0.5 -7.01 -0.36 1.28e-11 Blood pressure (smoking interaction); LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18337363 chr3:52569053 NT5DC2 0.25 5.77 0.3 1.81e-8 Electroencephalogram traits; LUSC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg04166393 chr7:2884313 GNA12 0.4 5.74 0.3 2.13e-8 Height; LUSC cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.64 9.79 0.47 4.78e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg25428297 chr7:1022841 CYP2W1 0.29 5.77 0.3 1.8e-8 Longevity;Endometriosis; LUSC trans rs7829975 0.514 rs2920991 chr8:8259117 T/A cg27411982 chr8:10470053 RP1L1 0.38 6.12 0.32 2.59e-9 Mood instability; LUSC cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg14993813 chr1:46806288 NSUN4 0.49 6.88 0.35 3.01e-11 Menopause (age at onset); LUSC cis rs11690935 0.550 rs6746701 chr2:172869255 G/A cg13550731 chr2:172543902 DYNC1I2 0.52 7.93 0.4 3.22e-14 Schizophrenia; LUSC cis rs1577917 0.916 rs7759727 chr6:86518878 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.47 -0.42 8.08e-16 Response to antipsychotic treatment; LUSC trans rs1728785 0.818 rs1728772 chr16:68584526 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs7246657 0.943 rs10415358 chr19:37808863 C/A cg23950597 chr19:37808831 NA -0.64 -7.74 -0.39 1.16e-13 Coronary artery calcification; LUSC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg13114125 chr14:105738426 BRF1 -0.92 -16.0 -0.66 3.5e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs7917772 0.582 rs10786689 chr10:104356359 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.94 0.51 5.25e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg18827107 chr12:86230957 RASSF9 0.43 6.46 0.33 3.78e-10 Major depressive disorder; LUSC cis rs7815909 0.610 rs4077819 chr8:57210682 G/T cg23139584 chr8:56987506 RPS20;SNORD54 -0.61 -7.75 -0.39 1.12e-13 Height; LUSC cis rs34779708 0.931 rs7084196 chr10:35367161 T/C cg03585969 chr10:35415529 CREM 0.6 8.81 0.43 6.71e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7267979 0.933 rs1130694 chr20:25276297 G/A cg08601574 chr20:25228251 PYGB 0.43 6.57 0.34 1.98e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg26408565 chr15:76604113 ETFA -0.49 -7.96 -0.4 2.66e-14 Blood metabolite levels; LUSC trans rs561341 0.709 rs11542477 chr17:30185892 A/G cg27661571 chr11:113659931 NA 0.65 6.51 0.34 2.83e-10 Hip circumference adjusted for BMI; LUSC trans rs649057 1.000 rs649057 chr9:102234323 G/T cg11260715 chr7:22602834 NA -0.63 -6.01 -0.31 4.76e-9 Smooth-surface caries;Dental caries;Otitis media;Otitis media (chronic); LUSC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg03806693 chr22:41940476 POLR3H 0.94 13.54 0.6 1.34e-33 Vitiligo; LUSC cis rs644799 0.625 rs1255175 chr11:95471186 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.58 8.86 0.44 4.85e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs7264396 0.563 rs2425122 chr20:34328848 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.26 -0.41 3.35e-15 Total cholesterol levels; LUSC trans rs1997103 1.000 rs6957984 chr7:55397331 G/A cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2439831 0.681 rs28578454 chr15:43603032 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.88 10.05 0.48 6.07e-21 Lung cancer in ever smokers; LUSC cis rs7267979 0.966 rs2261698 chr20:25259910 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.74 0.75 5.32e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 7.96 0.4 2.63e-14 Schizophrenia; LUSC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.71 10.42 0.5 3.45e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.5 6.16 0.32 2.15e-9 Multiple sclerosis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06419771 chr15:42264912 EHD4 0.45 6.46 0.33 3.61e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7267979 1.000 rs2482941 chr20:25361216 T/C cg03522245 chr20:25566470 NINL -0.35 -5.78 -0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7605827 0.930 rs12692262 chr2:15539084 A/G cg19274914 chr2:15703543 NA 0.46 8.96 0.44 2.28e-17 Educational attainment (years of education); LUSC cis rs7246657 0.943 rs2126977 chr19:37995747 C/G cg23950597 chr19:37808831 NA 0.58 7.15 0.36 5.63e-12 Coronary artery calcification; LUSC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.23e-12 Blood metabolite levels; LUSC cis rs13082711 0.871 rs13061912 chr3:27495586 A/G cg02860705 chr3:27208620 NA 0.47 7.8 0.39 8.1e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs9354308 0.933 rs2802064 chr6:66564352 C/T cg07460842 chr6:66804631 NA 0.49 5.97 0.31 6.2e-9 Metabolite levels; LUSC cis rs981844 1.000 rs17298985 chr4:154664261 C/T cg14289246 chr4:154710475 SFRP2 0.52 6.76 0.35 6.25e-11 Response to statins (LDL cholesterol change); LUSC cis rs73206853 0.925 rs12318836 chr12:110642190 A/C cg12870014 chr12:110450643 ANKRD13A 0.46 5.87 0.31 1.07e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9517320 1.000 rs12864890 chr13:99126457 T/C cg07423050 chr13:99094983 FARP1 0.34 6.41 0.33 5.07e-10 Longevity; LUSC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg07636037 chr3:49044803 WDR6 0.59 6.25 0.32 1.28e-9 Menarche (age at onset); LUSC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg16339924 chr4:17578868 LAP3 0.49 7.4 0.38 1.12e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg18404041 chr3:52824283 ITIH1 0.61 10.3 0.49 8.6e-22 Schizophrenia; LUSC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg20476274 chr7:133979776 SLC35B4 0.86 16.48 0.67 4.59e-45 Mean platelet volume; LUSC cis rs3771570 0.901 rs4075818 chr2:242432142 T/C cg21155796 chr2:242212141 HDLBP 0.61 6.84 0.35 3.83e-11 Prostate cancer; LUSC cis rs7000551 0.715 rs12544074 chr8:22338378 A/G cg12081754 chr8:22256438 SLC39A14 0.42 6.37 0.33 6.33e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg27572855 chr1:25598939 RHD 0.42 7.3 0.37 2.14e-12 Erythrocyte sedimentation rate; LUSC cis rs67072384 1.000 rs2365442 chr11:72450218 G/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.4e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs763121 0.853 rs8140617 chr22:38970439 A/G cg14440974 chr22:39074834 NA 0.36 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs1799949 0.602 rs8176199 chr17:41230524 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.58 8.59 0.43 3.41e-16 Menopause (age at onset); LUSC cis rs7904368 0.754 rs17139234 chr10:16849732 G/T cg14835575 chr10:16859367 RSU1 0.76 9.47 0.46 5.44e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs2625529 0.775 rs16956273 chr15:72117102 C/T cg16672083 chr15:72433130 SENP8 -0.48 -7.52 -0.38 5.09e-13 Red blood cell count; LUSC cis rs7851660 0.844 rs12343182 chr9:100624259 G/C cg13688889 chr9:100608707 NA -0.57 -9.08 -0.44 9.65e-18 Strep throat; LUSC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg07395648 chr5:131743802 NA 0.39 6.12 0.32 2.55e-9 Asthma (sex interaction); LUSC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg07952391 chr2:88470173 THNSL2 0.76 6.7 0.34 8.69e-11 Plasma clusterin levels; LUSC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.89 -0.31 9.49e-9 Major depressive disorder; LUSC cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg04455712 chr21:45112962 RRP1B 0.46 8.69 0.43 1.61e-16 Mean corpuscular volume; LUSC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 14.52 0.62 2.24e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.44 6.44 0.33 4.05e-10 Breast cancer; LUSC cis rs273573 1.000 rs156399 chr11:30955947 A/G cg14844989 chr11:31128820 NA 0.36 5.71 0.3 2.51e-8 Total body bone mineral density; LUSC cis rs10911251 0.546 rs7473 chr1:183114634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.66 0.5 5e-23 Colorectal cancer; LUSC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg03188948 chr7:1209495 NA 0.6 7.04 0.36 1.09e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6598955 0.671 rs17163751 chr1:26568698 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.69 -0.43 1.65e-16 Obesity-related traits; LUSC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.88 0.66 1.1e-42 Bladder cancer; LUSC cis rs9486719 1.000 rs12205655 chr6:96891733 T/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs2455601 1.000 rs11042108 chr11:8906021 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.56 -0.34 2e-10 Schizophrenia; LUSC cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg23649088 chr2:200775458 C2orf69 -0.53 -6.82 -0.35 4.37e-11 Schizophrenia; LUSC cis rs698813 0.604 rs12712917 chr2:44482190 A/G cg00619915 chr2:44497795 NA -0.52 -7.41 -0.38 1.06e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs9309711 0.737 rs9284795 chr2:3492065 G/A cg10845886 chr2:3471009 TTC15 -0.48 -6.35 -0.33 6.97e-10 Neurofibrillary tangles; LUSC cis rs751728 0.588 rs7774620 chr6:33736285 T/A cg25922239 chr6:33757077 LEMD2 0.42 6.25 0.32 1.25e-9 Crohn's disease; LUSC cis rs5758511 0.514 rs3985938 chr22:42511727 G/T cg00645731 chr22:42541494 CYP2D7P1 0.6 10.05 0.48 6.31e-21 Birth weight; LUSC cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg11266682 chr4:10021025 SLC2A9 -0.5 -8.92 -0.44 3.08e-17 Bone mineral density; LUSC cis rs12911832 0.701 rs452698 chr15:59105571 A/G cg05156742 chr15:59063176 FAM63B 0.55 8.57 0.42 3.76e-16 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26801646 chr10:76970496 VDAC2 0.45 7.44 0.38 8.45e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7726839 0.561 rs4957048 chr5:583442 G/A cg25482853 chr8:67687455 SGK3 1.03 15.45 0.65 5.41e-41 Obesity-related traits; LUSC cis rs2463822 1.000 rs11231050 chr11:62131660 C/G cg06239285 chr11:62104954 ASRGL1 -0.86 -9.87 -0.48 2.48e-20 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12421382 0.614 rs12799395 chr11:109390862 G/T cg16359550 chr11:109292809 C11orf87 0.32 5.78 0.3 1.74e-8 Schizophrenia; LUSC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs733592 0.524 rs10875741 chr12:48492922 A/C cg24011408 chr12:48396354 COL2A1 -0.53 -8.72 -0.43 1.35e-16 Plateletcrit; LUSC cis rs3106136 0.967 rs4693377 chr4:95157256 G/C cg11021082 chr4:95130006 SMARCAD1 -0.34 -5.93 -0.31 7.72e-9 Capecitabine sensitivity; LUSC cis rs950169 0.810 rs2879976 chr15:85109578 G/A cg17507749 chr15:85114479 UBE2QP1 0.7 9.24 0.45 3.03e-18 Schizophrenia; LUSC cis rs12519773 1.000 rs4470752 chr5:92460541 C/T cg18783429 chr5:92414398 NA 0.29 6.48 0.33 3.2e-10 Migraine; LUSC cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg22532475 chr10:104410764 TRIM8 -0.29 -5.9 -0.31 8.72e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg22455342 chr2:225449267 CUL3 0.82 11.36 0.53 1.69e-25 IgE levels in asthmatics (D.p. specific); LUSC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg11344533 chr11:111475393 SIK2 -0.46 -6.31 -0.33 8.96e-10 Primary sclerosing cholangitis; LUSC cis rs11098499 0.954 rs10518328 chr4:120401779 G/A cg24375607 chr4:120327624 NA 0.79 11.91 0.55 1.72e-27 Corneal astigmatism; LUSC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg12437481 chr16:420112 MRPL28 -0.54 -9.45 -0.46 6.32e-19 Bone mineral density (spine);Bone mineral density; LUSC cis rs752010 0.746 rs11210499 chr1:42089703 C/T cg06885757 chr1:42089581 HIVEP3 -0.53 -11.24 -0.52 4.64e-25 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg07936489 chr17:37558343 FBXL20 -0.73 -10.0 -0.48 8.94e-21 Glomerular filtration rate (creatinine); LUSC cis rs597539 0.521 rs2060982 chr11:68612927 A/G cg06112835 chr11:68658793 MRPL21 0.38 6.42 0.33 4.78e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2290416 0.892 rs62523607 chr8:144667432 G/A cg14809332 chr8:144654887 C8orf73 0.54 6.51 0.34 2.78e-10 Attention deficit hyperactivity disorder; LUSC cis rs4409675 0.576 rs7533918 chr1:28230667 G/A cg23691781 chr1:28212827 C1orf38 0.32 7.65 0.39 2.21e-13 Corneal astigmatism; LUSC trans rs2797160 0.905 rs1418641 chr6:125999854 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.59 -0.34 1.71e-10 Endometrial cancer; LUSC cis rs7937682 0.921 rs10789841 chr11:111469582 T/C cg09085632 chr11:111637200 PPP2R1B 0.97 13.91 0.61 5.25e-35 Primary sclerosing cholangitis; LUSC cis rs2797160 1.000 rs2797154 chr6:126005197 A/G cg05901451 chr6:126070800 HEY2 -0.58 -8.59 -0.43 3.43e-16 Endometrial cancer; LUSC cis rs9473147 0.543 rs9473126 chr6:47481833 C/G cg12968598 chr6:47444699 CD2AP 0.53 8.07 0.4 1.32e-14 Platelet distribution width;Mean platelet volume; LUSC trans rs9329221 0.736 rs34381075 chr8:10243785 C/G cg15556689 chr8:8085844 FLJ10661 0.63 9.09 0.45 9.32e-18 Neuroticism; LUSC cis rs2050392 0.517 rs2489847 chr10:30743673 G/A cg18806716 chr10:30721971 MAP3K8 -0.65 -9.73 -0.47 7.45e-20 Inflammatory bowel disease; LUSC cis rs11098499 0.863 rs13136462 chr4:120543173 C/T cg09307838 chr4:120376055 NA 0.72 10.4 0.49 3.85e-22 Corneal astigmatism; LUSC cis rs11696845 0.626 rs4810439 chr20:43377870 C/G cg25301532 chr20:43378953 KCNK15 -0.34 -5.97 -0.31 6.01e-9 Obesity-related traits; LUSC cis rs748404 0.697 rs567357 chr15:43571390 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.56 8.76 0.43 1.03e-16 Lung cancer; LUSC cis rs11958404 0.615 rs7724696 chr5:157450852 A/C cg05962755 chr5:157440814 NA 0.39 5.71 0.3 2.53e-8 IgG glycosylation; LUSC cis rs887829 0.569 rs4148326 chr2:234673462 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.63 -0.39 2.53e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs79057730 0.599 rs6951032 chr7:794092 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.77 7.55 0.38 4.1e-13 Initial pursuit acceleration; LUSC cis rs6546550 0.901 rs6546559 chr2:70145833 G/A cg02498382 chr2:70120550 SNRNP27 -0.29 -7.29 -0.37 2.2e-12 Prevalent atrial fibrillation; LUSC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.96 -0.44 2.36e-17 Gut microbiome composition (summer); LUSC cis rs2286503 0.780 rs981792 chr7:22861639 C/A cg11367502 chr7:22862612 TOMM7 0.46 6.17 0.32 1.96e-9 Fibrinogen; LUSC cis rs6722750 0.682 rs1866048 chr2:64416837 A/G cg22352474 chr2:64371530 PELI1 -0.53 -7.96 -0.4 2.76e-14 Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19082003 chr1:231004179 C1orf198 -0.43 -6.25 -0.32 1.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg26587870 chr6:27730563 NA -0.64 -6.15 -0.32 2.16e-9 Depression; LUSC cis rs12950390 0.853 rs17773010 chr17:45858297 C/T cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.51e-10 IgG glycosylation; LUSC trans rs6502050 0.799 rs8066370 chr17:80102105 T/C cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg02269571 chr22:50332266 NA -0.59 -8.72 -0.43 1.31e-16 Schizophrenia; LUSC cis rs440932 0.798 rs330942 chr8:9020439 A/C cg06636001 chr8:8085503 FLJ10661 0.42 6.19 0.32 1.73e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs6977660 1.000 rs6959889 chr7:19822024 A/C cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.647 rs11072618 chr15:77019342 A/G cg23625390 chr15:77176239 SCAPER -0.67 -10.08 -0.48 5.01e-21 Blood metabolite levels; LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.77 0.47 5.19e-20 Bipolar disorder; LUSC cis rs826838 0.809 rs11169666 chr12:39211300 T/C cg13010199 chr12:38710504 ALG10B 0.69 11.78 0.54 5.17e-27 Heart rate; LUSC cis rs12122100 0.774 rs12723253 chr1:146523303 C/T cg03526459 chr1:146549940 NA -0.41 -6.59 -0.34 1.72e-10 HIV-1 control; LUSC trans rs393155 0.517 rs330050 chr8:9087679 G/C cg06636001 chr8:8085503 FLJ10661 -0.55 -8.28 -0.41 3.08e-15 Neuroticism; LUSC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.81 12.37 0.56 3.42e-29 Cognitive test performance; LUSC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg07936489 chr17:37558343 FBXL20 -0.69 -9.62 -0.47 1.67e-19 Glomerular filtration rate (creatinine); LUSC cis rs58749629 1.000 rs58749629 chr20:44571317 G/A cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.54 -6.04 -0.31 4.08e-9 Abdominal aortic aneurysm; LUSC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg21951975 chr1:209979733 IRF6 0.55 8.22 0.41 4.41e-15 Cleft lip with or without cleft palate; LUSC cis rs11955175 1.000 rs11960585 chr5:40662007 C/A cg05478818 chr5:40835740 RPL37 0.7 5.69 0.3 2.74e-8 Bipolar disorder and schizophrenia; LUSC cis rs1127311 0.905 rs6699729 chr1:154582896 A/T cg17218026 chr1:154582156 ADAR 0.56 10.06 0.48 5.92e-21 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9858542 1.000 rs9836291 chr3:49697459 G/A cg03060546 chr3:49711283 APEH -0.69 -10.13 -0.48 3.24e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs4704187 0.663 rs12523187 chr5:74379625 A/T cg03227963 chr5:74354835 NA 0.31 6.73 0.35 7.4e-11 Response to amphetamines; LUSC cis rs11122272 0.735 rs2749709 chr1:231530476 G/T cg06096015 chr1:231504339 EGLN1 0.57 10.33 0.49 6.72e-22 Hemoglobin concentration; LUSC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg00784671 chr22:46762841 CELSR1 -0.48 -6.24 -0.32 1.32e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg08219700 chr8:58056026 NA 0.69 8.22 0.41 4.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg24675658 chr1:53192096 ZYG11B 0.62 9.86 0.47 2.63e-20 Monocyte count; LUSC cis rs372883 0.532 rs425989 chr21:30715275 T/C cg24692254 chr21:30365293 RNF160 -0.56 -8.2 -0.41 5.35e-15 Pancreatic cancer; LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03352830 chr11:487213 PTDSS2 0.71 8.65 0.43 2.24e-16 Body mass index; LUSC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg08499158 chr17:42289980 UBTF -0.48 -7.79 -0.39 8.46e-14 Total body bone mineral density; LUSC cis rs672059 1.000 rs546183 chr1:183157753 A/G ch.1.3577855R chr1:183094577 LAMC1 0.55 7.98 0.4 2.3e-14 Hypertriglyceridemia; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.0 22.2 0.77 9.81e-68 Prudent dietary pattern; LUSC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg02038168 chr22:39784481 NA -0.49 -7.85 -0.39 5.76e-14 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.591 rs11674569 chr2:101010860 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.64 -0.43 2.34e-16 Intelligence (multi-trait analysis); LUSC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg21171335 chr12:122356390 WDR66 0.61 9.22 0.45 3.37e-18 Mean corpuscular volume; LUSC cis rs477692 0.563 rs12266634 chr10:131412659 G/C cg05714579 chr10:131428358 MGMT -0.76 -12.27 -0.56 8.04e-29 Response to temozolomide; LUSC cis rs6469656 1.000 rs1347626 chr8:117656781 T/C cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC trans rs61931739 0.517 rs10844830 chr12:34308133 C/T cg13010199 chr12:38710504 ALG10B 0.45 6.97 0.36 1.68e-11 Morning vs. evening chronotype; LUSC cis rs4356932 1.000 rs6850515 chr4:76973751 C/T cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs2760061 0.598 rs849904 chr1:228137145 G/C cg01973587 chr1:228161476 NA 0.47 8.47 0.42 7.96e-16 Diastolic blood pressure; LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13012494 chr21:47604986 C21orf56 0.47 7.13 0.36 6.42e-12 Testicular germ cell tumor; LUSC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.5 0.38 5.63e-13 Multiple sclerosis; LUSC cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg23711669 chr6:146136114 FBXO30 -0.82 -14.58 -0.62 1.32e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs7647973 0.769 rs4974081 chr3:49070499 A/G cg21141812 chr3:48556323 PFKFB4 -0.34 -6.23 -0.32 1.43e-9 Menarche (age at onset); LUSC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg02782426 chr3:40428986 ENTPD3 0.35 6.6 0.34 1.66e-10 Renal cell carcinoma; LUSC cis rs9653442 0.835 rs7565967 chr2:100744683 G/T cg22139774 chr2:100720529 AFF3 -0.54 -9.6 -0.47 1.93e-19 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14322403 chr8:57123418 PLAG1;CHCHD7 0.37 5.97 0.31 6.05e-9 Mosquito bite size; LUSC cis rs9905704 0.647 rs12944274 chr17:57041293 C/G cg05425664 chr17:57184151 TRIM37 0.41 6.2 0.32 1.71e-9 Testicular germ cell tumor; LUSC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.45 -0.42 8.85e-16 Total body bone mineral density; LUSC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg06713675 chr4:122721982 EXOSC9 -0.46 -8.14 -0.41 7.83e-15 Type 2 diabetes; LUSC cis rs698813 0.604 rs7606004 chr2:44479983 G/A cg00619915 chr2:44497795 NA -0.53 -7.42 -0.38 9.62e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs208520 1.000 rs208521 chr6:66953625 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.34 -0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg06108461 chr20:60628389 TAF4 -0.72 -11.16 -0.52 8.52e-25 Body mass index; LUSC cis rs11098499 0.909 rs1546502 chr4:120235898 A/G cg09307838 chr4:120376055 NA 0.81 11.74 0.54 7.02e-27 Corneal astigmatism; LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg04518342 chr5:131593106 PDLIM4 0.42 7.43 0.38 9.23e-13 Blood metabolite levels; LUSC cis rs11229555 0.609 rs7927730 chr11:58187906 G/A cg15696309 chr11:58395628 NA -0.64 -7.77 -0.39 9.83e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6693567 0.565 rs8006 chr1:150280801 G/C cg15654264 chr1:150340011 RPRD2 -0.45 -7.39 -0.37 1.22e-12 Migraine; LUSC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg17158414 chr2:27665306 KRTCAP3 -0.34 -6.56 -0.34 2.09e-10 Total body bone mineral density; LUSC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC cis rs7923609 0.967 rs10509186 chr10:65207018 C/T cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.03e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs8092503 1.000 rs12960467 chr18:52492951 C/G cg12377874 chr18:52495404 RAB27B 0.33 5.79 0.3 1.59e-8 Childhood body mass index; LUSC cis rs9325144 0.560 rs7314632 chr12:38636979 C/T cg26384229 chr12:38710491 ALG10B -0.67 -10.31 -0.49 7.76e-22 Morning vs. evening chronotype; LUSC cis rs10911232 0.524 rs10911209 chr1:183013988 T/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.67e-24 Hypertriglyceridemia; LUSC cis rs2760061 0.624 rs10442629 chr1:228191070 T/A cg04850211 chr1:228464232 OBSCN -0.33 -5.7 -0.3 2.69e-8 Diastolic blood pressure; LUSC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.91 0.48 1.78e-20 Bipolar disorder; LUSC cis rs2303282 0.716 rs4620948 chr16:56439776 A/G cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.88e-12 Breast cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23260190 chr10:101419318 ENTPD7 -0.47 -6.05 -0.31 3.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs11030122 0.673 rs10835601 chr11:4106416 G/A cg08557956 chr11:4115526 RRM1 -0.47 -6.03 -0.31 4.31e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs701145 0.585 rs4680125 chr3:153784698 G/A cg17054900 chr3:154042577 DHX36 -0.73 -7.44 -0.38 8.72e-13 Coronary artery disease; LUSC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg12403142 chr1:92012408 NA -0.38 -6.12 -0.32 2.7e-9 Breast cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23121547 chr11:1593657 HCCA2;LOC338651;DUSP8 -0.53 -6.28 -0.32 1.03e-9 Bipolar disorder and schizophrenia; LUSC trans rs7618501 0.574 rs6765484 chr3:50041313 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -8.43 -0.42 1.06e-15 Intelligence (multi-trait analysis); LUSC cis rs250677 0.687 rs171636 chr5:148434545 G/A cg18129178 chr5:148520854 ABLIM3 -0.73 -10.05 -0.48 6.34e-21 Breast cancer; LUSC cis rs7177699 0.557 rs9920968 chr15:79118747 G/A cg00540400 chr15:79124168 NA 0.45 7.94 0.4 3.18e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1865721 0.804 rs7243462 chr18:73147998 A/T cg26385618 chr18:73139727 C18orf62 -0.52 -9.51 -0.46 3.94e-19 Intelligence; LUSC cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg18252515 chr7:66147081 NA -0.57 -7.89 -0.4 4.26e-14 Corneal structure; LUSC trans rs1005277 0.579 rs1780115 chr10:38524773 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.51 -0.46 3.89e-19 Extrinsic epigenetic age acceleration; LUSC trans rs12637928 0.580 rs13078633 chr3:110253113 A/G cg17371621 chr15:61264283 RORA 0.36 5.96 0.31 6.51e-9 Neuroticism; LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg08280861 chr8:58055591 NA 0.57 6.2 0.32 1.67e-9 Developmental language disorder (linguistic errors); LUSC cis rs2898290 0.622 rs13272061 chr8:11352261 G/T cg27411982 chr8:10470053 RP1L1 -0.43 -6.98 -0.36 1.62e-11 Systolic blood pressure; LUSC trans rs1814175 0.817 rs2866863 chr11:49953242 C/T cg15704280 chr7:45808275 SEPT13 -1.13 -24.99 -0.81 1.8e-78 Height; LUSC cis rs9303401 0.703 rs9910629 chr17:57210301 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.48 7.02 0.36 1.23e-11 Cognitive test performance; LUSC cis rs2580764 0.566 rs2972075 chr2:55292322 T/G cg20993754 chr2:55226987 RTN4 -0.36 -6.06 -0.31 3.73e-9 Mean platelet volume; LUSC cis rs501916 0.634 rs3803349 chr15:48064867 T/A cg16110827 chr15:48056943 SEMA6D -0.39 -6.16 -0.32 2.1e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg06873352 chr17:61820015 STRADA 0.72 12.88 0.58 4.42e-31 Prudent dietary pattern; LUSC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg12615879 chr12:58013172 SLC26A10 -0.29 -5.94 -0.31 7.18e-9 Multiple sclerosis; LUSC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg05585544 chr11:47624801 NA -0.42 -7.35 -0.37 1.5e-12 Subjective well-being; LUSC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg15704280 chr7:45808275 SEPT13 -1.04 -18.06 -0.7 2.45e-51 Coronary artery disease; LUSC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7617773 0.780 rs35411187 chr3:48360017 C/G cg20734569 chr3:48348370 SPINK8 -0.47 -7.93 -0.4 3.4e-14 Coronary artery disease; LUSC cis rs921968 0.643 rs545779 chr2:219336108 A/G cg02176678 chr2:219576539 TTLL4 0.64 11.63 0.54 1.77e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs9303542 0.625 rs4239209 chr17:46574317 T/A cg09704116 chr17:46666958 LOC404266 0.31 5.81 0.3 1.44e-8 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs6963495 0.585 rs1728653 chr7:105191335 A/G cg13798780 chr7:105162888 PUS7 0.52 6.56 0.34 2.11e-10 Bipolar disorder (body mass index interaction); LUSC cis rs9611519 0.929 rs73174660 chr22:41437304 T/C cg03806693 chr22:41940476 POLR3H -0.54 -7.3 -0.37 2.11e-12 Neuroticism; LUSC cis rs908922 0.676 rs6674451 chr1:152531054 C/T cg20991723 chr1:152506922 NA 0.49 9.21 0.45 3.74e-18 Hair morphology; LUSC cis rs12893668 0.703 rs2403197 chr14:104053764 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -6.0 -0.31 5.1e-9 Reticulocyte count; LUSC cis rs9462027 0.628 rs9469863 chr6:34739649 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.74 -0.3 2.08e-8 Systemic lupus erythematosus; LUSC trans rs8002861 0.901 rs9525867 chr13:44463557 G/A cg12856521 chr11:46389249 DGKZ 0.4 6.19 0.32 1.73e-9 Leprosy; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg00431813 chr7:1051703 C7orf50 -0.38 -5.97 -0.31 6.08e-9 Longevity;Endometriosis; LUSC cis rs2777491 0.915 rs7165675 chr15:41614704 T/C cg18705301 chr15:41695430 NDUFAF1 -0.73 -13.36 -0.59 6.47e-33 Ulcerative colitis; LUSC cis rs7582180 0.606 rs11684004 chr2:100954783 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.65 -0.43 2.26e-16 Intelligence (multi-trait analysis); LUSC cis rs9393692 0.645 rs9467703 chr6:26318903 A/G cg00631329 chr6:26305371 NA -0.54 -10.6 -0.5 8.12e-23 Educational attainment; LUSC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs4655582 0.527 rs4655794 chr1:66159301 T/C cg04111102 chr1:66153794 NA 0.27 5.69 0.3 2.74e-8 Fibrinogen levels; LUSC cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg01884057 chr2:25150051 NA 0.49 11.42 0.53 9.77e-26 Body mass index; LUSC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.76 -13.74 -0.6 2.24e-34 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg18681998 chr4:17616180 MED28 0.85 15.11 0.64 1.17e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.39 -0.38 1.15e-12 Alzheimer's disease (late onset); LUSC trans rs2243480 1.000 rs4718269 chr7:65200778 C/G cg10756647 chr7:56101905 PSPH -0.81 -8.22 -0.41 4.4e-15 Diabetic kidney disease; LUSC cis rs17828380 1.000 rs34119905 chr15:63490547 C/T cg05507819 chr15:63340323 TPM1 -0.7 -5.9 -0.31 9.09e-9 Social communication problems; LUSC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg12560992 chr17:57184187 TRIM37 -0.82 -14.75 -0.63 2.92e-38 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg07606381 chr6:8435919 SLC35B3 0.75 12.72 0.57 1.74e-30 Motion sickness; LUSC cis rs11828289 0.660 rs79045664 chr11:23238737 G/A cg20040320 chr11:23191996 NA -0.63 -6.19 -0.32 1.79e-9 Cancer; LUSC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg00999904 chr2:3704751 ALLC -0.44 -6.77 -0.35 5.73e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC trans rs2727020 0.576 rs1814175 chr11:49559172 T/C cg03929089 chr4:120376271 NA -0.94 -16.07 -0.66 1.96e-43 Coronary artery disease; LUSC cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs3820928 0.874 rs2177593 chr2:227833869 G/A cg11843606 chr2:227700838 RHBDD1 -0.51 -7.39 -0.37 1.18e-12 Pulmonary function; LUSC cis rs559928 0.557 rs7122408 chr11:63898826 G/T cg24687543 chr11:63912206 MACROD1 0.46 5.93 0.31 7.47e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.66 -7.07 -0.36 9.01e-12 Birth weight; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg26253258 chr20:60697513 LSM14B -0.46 -6.0 -0.31 5.19e-9 Cognitive function;Information processing speed; LUSC cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg26384229 chr12:38710491 ALG10B 0.9 14.93 0.63 5.72e-39 Bladder cancer; LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg22920501 chr2:26401640 FAM59B -0.79 -11.59 -0.54 2.53e-26 Gut microbiome composition (summer); LUSC cis rs4566357 0.595 rs6707286 chr2:227911400 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -8.3 -0.41 2.67e-15 Coronary artery disease; LUSC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg03709012 chr19:19516395 GATAD2A 0.86 14.42 0.62 5.3e-37 Tonsillectomy; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg12432903 chr7:1882776 MAD1L1 0.51 8.65 0.43 2.25e-16 Bipolar disorder and schizophrenia; LUSC cis rs9467773 0.967 rs1056347 chr6:26527524 G/C cg05738196 chr6:26577821 NA 0.81 15.72 0.65 4.7e-42 Intelligence (multi-trait analysis); LUSC cis rs1160297 0.633 rs12477231 chr2:53084648 T/G cg07782112 chr2:53107842 NA 0.4 6.41 0.33 4.89e-10 Hemostatic factors and hematological phenotypes; LUSC trans rs7824557 0.564 rs6601584 chr8:11232343 C/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.79 -0.39 8.77e-14 Retinal vascular caliber; LUSC cis rs9644630 0.841 rs4292704 chr8:19329303 G/C cg06562184 chr8:19319451 CSGALNACT1 0.41 6.04 0.31 4.22e-9 Oropharynx cancer; LUSC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg18306943 chr3:40428807 ENTPD3 0.39 6.09 0.32 3.13e-9 Renal cell carcinoma; LUSC cis rs2274273 0.773 rs8006525 chr14:55813394 T/G cg04306507 chr14:55594613 LGALS3 0.56 12.81 0.57 7.72e-31 Protein biomarker; LUSC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg02807482 chr3:125708958 NA -0.54 -6.68 -0.34 1.02e-10 Blood pressure (smoking interaction); LUSC cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs193541 0.632 rs4835896 chr5:122121240 C/T cg19077854 chr5:122220652 SNX24 -0.39 -8.24 -0.41 3.85e-15 Glucose homeostasis traits; LUSC cis rs12900413 0.840 rs28700196 chr15:90297238 G/T cg24249390 chr15:90295951 MESP1 -0.48 -7.33 -0.37 1.71e-12 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1372520 0.627 rs2583964 chr4:90727218 A/G cg15133208 chr4:90757351 SNCA -0.55 -8.63 -0.43 2.6e-16 Neuroticism; LUSC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg16624210 chr5:671434 TPPP 0.49 6.05 0.31 3.83e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7119 0.671 rs10152850 chr15:77904426 G/A cg27398640 chr15:77910606 LINGO1 0.39 8.97 0.44 2.16e-17 Type 2 diabetes; LUSC cis rs11229555 0.645 rs10896814 chr11:58430699 T/C cg15696309 chr11:58395628 NA -0.63 -6.7 -0.34 8.8e-11 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs12410462 0.681 rs4614224 chr1:227574966 C/T cg04117972 chr1:227635322 NA 0.62 6.59 0.34 1.73e-10 Major depressive disorder; LUSC cis rs10100465 0.855 rs1396351 chr8:118689728 A/G cg09430518 chr8:118662568 NA 0.32 5.87 0.31 1.05e-8 Leprosy; LUSC cis rs9309711 0.736 rs9678647 chr2:3497036 A/G cg10845886 chr2:3471009 TTC15 0.45 5.85 0.3 1.19e-8 Neurofibrillary tangles; LUSC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg16624210 chr5:671434 TPPP 0.47 5.92 0.31 8.21e-9 Lung disease severity in cystic fibrosis; LUSC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg07936489 chr17:37558343 FBXL20 0.72 9.92 0.48 1.64e-20 Glomerular filtration rate (creatinine); LUSC cis rs4356932 1.000 rs6532157 chr4:76974373 C/T cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg27121462 chr16:89883253 FANCA 0.54 8.65 0.43 2.27e-16 Vitiligo; LUSC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg06212747 chr3:49208901 KLHDC8B 0.43 5.84 0.3 1.24e-8 Parkinson's disease; LUSC cis rs7605827 0.897 rs763355 chr2:15518838 A/G cg19274914 chr2:15703543 NA 0.47 9.2 0.45 4.07e-18 Educational attainment (years of education); LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg13732083 chr21:47605072 C21orf56 -0.45 -6.7 -0.34 8.72e-11 Testicular germ cell tumor; LUSC cis rs10392 0.571 rs4812350 chr20:37631192 C/T cg27552599 chr20:37590471 DHX35 0.47 7.84 0.39 6.16e-14 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs9329221 0.710 rs11249995 chr8:10238922 T/C cg21775007 chr8:11205619 TDH 0.47 6.33 0.33 8.03e-10 Neuroticism; LUSC cis rs77633900 0.772 rs284898 chr15:76750695 A/G cg21673338 chr15:77095150 SCAPER -0.7 -5.95 -0.31 6.83e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg18105134 chr13:113819100 PROZ -0.66 -9.53 -0.46 3.35e-19 Platelet distribution width; LUSC cis rs7809950 0.678 rs7790080 chr7:107031322 G/A cg23024343 chr7:107201750 COG5 -0.68 -9.97 -0.48 1.12e-20 Coronary artery disease; LUSC cis rs11039100 0.850 rs12363855 chr11:5830186 G/C cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11439475 chr15:52821378 MYO5A -0.48 -5.97 -0.31 5.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs4664308 0.806 rs4665162 chr2:161060184 A/G cg03641300 chr2:160917029 PLA2R1 -0.62 -10.69 -0.51 3.8e-23 Idiopathic membranous nephropathy; LUSC cis rs9300255 0.569 rs1716170 chr12:123716513 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.94 -0.31 7.31e-9 Neutrophil percentage of white cells; LUSC cis rs12421382 1.000 rs12421382 chr11:109378071 C/T cg16359550 chr11:109292809 C11orf87 0.41 6.84 0.35 3.69e-11 Schizophrenia; LUSC cis rs7173743 1.000 rs4567668 chr15:79140692 T/C cg00540400 chr15:79124168 NA -0.33 -5.72 -0.3 2.39e-8 Coronary artery disease; LUSC cis rs8114671 0.935 rs35193912 chr20:33785050 C/T cg07148914 chr20:33460835 GGT7 -0.44 -6.58 -0.34 1.82e-10 Height; LUSC cis rs2242116 0.932 rs4683301 chr3:46931478 A/T cg02527881 chr3:46936655 PTH1R 0.77 16.77 0.68 3.29e-46 Birth weight; LUSC cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 5.68 0.3 2.94e-8 Rheumatoid arthritis; LUSC cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg04455712 chr21:45112962 RRP1B -0.45 -8.72 -0.43 1.38e-16 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg08677398 chr8:58056175 NA 0.53 6.98 0.36 1.61e-11 Developmental language disorder (linguistic errors); LUSC cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.01 0.48 8.14e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.84 -0.44 5.55e-17 Monocyte percentage of white cells; LUSC cis rs7091068 0.671 rs1764322 chr10:95406276 T/G cg20715218 chr10:95462985 C10orf4 -0.62 -7.29 -0.37 2.29e-12 Urinary tract infection frequency; LUSC cis rs1577917 0.518 rs6454482 chr6:86418188 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.42 6.72 0.34 8.07e-11 Response to antipsychotic treatment; LUSC cis rs6754311 0.731 rs6719488 chr2:136575199 G/T cg07169764 chr2:136633963 MCM6 -0.58 -7.55 -0.38 4.27e-13 Mosquito bite size; LUSC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg08773314 chr2:239334832 ASB1 0.44 9.54 0.46 3.16e-19 Multiple system atrophy; LUSC cis rs2404602 0.647 rs12914196 chr15:76941361 C/T cg23625390 chr15:77176239 SCAPER -0.64 -9.67 -0.47 1.12e-19 Blood metabolite levels; LUSC cis rs6138458 1.000 rs11905625 chr20:24977065 A/C cg26195577 chr20:24973756 C20orf3 1.11 18.48 0.71 5e-53 Blood protein levels; LUSC cis rs3960554 0.740 rs10216079 chr7:75690988 A/C cg17325771 chr7:75508891 RHBDD2 -0.4 -5.65 -0.3 3.52e-8 Eotaxin levels; LUSC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg12463550 chr7:65579703 CRCP -0.53 -7.72 -0.39 1.4e-13 Aortic root size; LUSC cis rs6545883 0.929 rs55806663 chr2:61740487 G/T cg15711740 chr2:61764176 XPO1 -0.5 -7.94 -0.4 3.03e-14 Tuberculosis; LUSC cis rs9341808 0.529 rs9350851 chr6:81059188 A/G cg08355045 chr6:80787529 NA 0.47 7.86 0.4 5.35e-14 Sitting height ratio; LUSC cis rs965604 1.000 rs12904234 chr15:78779384 C/T cg18825076 chr15:78729989 IREB2 -0.43 -6.93 -0.35 2.12e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg07701084 chr6:150067640 NUP43 0.55 8.15 0.41 7.52e-15 Lung cancer; LUSC cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.61 -0.6 7.35e-34 Chronic sinus infection; LUSC cis rs3768617 0.528 rs6686682 chr1:183080539 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.84 0.51 1.15e-23 Fuchs's corneal dystrophy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19941170 chr5:172067912 NEURL1B 0.43 6.68 0.34 1.02e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6580649 1.000 rs6580647 chr12:48403229 G/T cg24011408 chr12:48396354 COL2A1 -0.53 -7.35 -0.37 1.49e-12 Lung cancer; LUSC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.44 6.24 0.32 1.33e-9 Osteoporosis; LUSC trans rs2018683 0.707 rs1021691 chr7:28974496 C/T cg19402173 chr7:128379420 CALU -0.47 -7.23 -0.37 3.36e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC trans rs12310956 0.510 rs11612987 chr12:33879130 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.92 0.35 2.25e-11 Morning vs. evening chronotype; LUSC cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg17063962 chr7:91808500 NA 0.56 8.51 0.42 5.95e-16 Breast cancer; LUSC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg03351412 chr1:154909251 PMVK 0.49 7.48 0.38 6.61e-13 Prostate cancer; LUSC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg03433033 chr1:76189801 ACADM 0.83 13.25 0.59 1.78e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs62400317 0.859 rs62436780 chr6:45128261 A/T cg20913747 chr6:44695427 NA -0.46 -7.49 -0.38 6.22e-13 Total body bone mineral density; LUSC cis rs950169 0.922 rs6603022 chr15:84830170 T/C cg12863693 chr15:85201151 NMB -0.35 -7.24 -0.37 3.1e-12 Schizophrenia; LUSC trans rs747782 0.585 rs1604655 chr11:48274778 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.34 9.51e-11 Intraocular pressure; LUSC trans rs72674100 1.000 rs28630925 chr4:97991385 G/T cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.53e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13372927 chr11:111896293 DLAT -0.41 -6.1 -0.32 2.97e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13315871 0.929 rs7635697 chr3:58313706 G/A cg12435725 chr3:58293450 RPP14 -0.76 -7.39 -0.37 1.23e-12 Cholesterol, total; LUSC cis rs9902453 0.967 rs7222685 chr17:28496430 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.18 0.41 5.84e-15 Coffee consumption (cups per day); LUSC cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg24812749 chr6:127587940 RNF146 0.73 10.44 0.5 2.79e-22 Breast cancer; LUSC cis rs72781680 0.898 rs72782136 chr2:24047344 A/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg03248196 chr12:48214108 HDAC7 -0.49 -6.06 -0.31 3.67e-9 Neuroticism; LUSC cis rs9527 1.000 rs9527 chr10:104623578 C/T cg23093090 chr10:104574429 C10orf26 -0.42 -6.86 -0.35 3.32e-11 Arsenic metabolism; LUSC cis rs295140 0.903 rs56326533 chr2:201168758 T/C cg04283868 chr2:201171347 SPATS2L 0.43 6.45 0.33 3.85e-10 QT interval; LUSC cis rs7241530 0.662 rs67266500 chr18:75907596 C/T cg14642773 chr18:75888474 NA 0.38 5.64 0.3 3.56e-8 Educational attainment (years of education); LUSC cis rs1577917 0.740 rs6926049 chr6:86266133 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 10.78 0.51 1.92e-23 Response to antipsychotic treatment; LUSC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg06028605 chr16:24865363 SLC5A11 -0.5 -8.94 -0.44 2.66e-17 Intelligence (multi-trait analysis); LUSC cis rs61931739 0.500 rs11053278 chr12:34555955 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg02788857 chr8:22132959 PIWIL2 0.39 7.52 0.38 5.14e-13 Hypertriglyceridemia; LUSC cis rs17818399 0.547 rs13020299 chr2:46758717 A/G cg02822958 chr2:46747628 ATP6V1E2 0.41 6.06 0.31 3.75e-9 Height; LUSC cis rs897080 0.515 rs1067402 chr2:44676226 C/T cg00619915 chr2:44497795 NA 0.41 5.67 0.3 3.13e-8 Height; LUSC cis rs12701220 0.817 rs59471534 chr7:1085224 G/A cg26769984 chr7:1090371 C7orf50 0.7 10.59 0.5 8.55e-23 Bronchopulmonary dysplasia; LUSC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg03709012 chr19:19516395 GATAD2A -0.8 -12.74 -0.57 1.44e-30 Tonsillectomy; LUSC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Parkinson's disease; LUSC cis rs13394619 0.744 rs10929759 chr2:11722012 C/G cg07314298 chr2:11723111 GREB1 0.56 10.19 0.49 2.04e-21 Endometriosis; LUSC cis rs28374715 0.662 rs72737793 chr15:41516823 C/T cg18705301 chr15:41695430 NDUFAF1 -0.82 -14.22 -0.61 3.17e-36 Ulcerative colitis; LUSC cis rs7954584 0.616 rs10743186 chr12:122356436 C/T cg13699009 chr12:122356056 WDR66 0.45 6.81 0.35 4.68e-11 Mean corpuscular volume; LUSC cis rs4845570 0.920 rs6694952 chr1:151760131 T/C cg07092448 chr1:151763213 TDRKH 1.27 14.77 0.63 2.37e-38 Coronary artery disease; LUSC cis rs12989701 1.000 rs13009551 chr2:127889118 C/T cg08168897 chr2:127865431 BIN1 0.72 8.24 0.41 4.06e-15 Alzheimer's disease (late onset); LUSC cis rs477895 1.000 rs66968227 chr11:64070930 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 6.97 0.36 1.66e-11 Mean platelet volume; LUSC cis rs2115630 0.967 rs8028490 chr15:85277888 G/A cg11189052 chr15:85197271 WDR73 -0.44 -6.48 -0.33 3.35e-10 P wave terminal force; LUSC cis rs7572644 0.941 rs2337700 chr2:28306943 G/A cg27432699 chr2:27873401 GPN1 0.52 6.22 0.32 1.52e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15541040 chr2:3486749 NA -0.57 -8.77 -0.43 9.07e-17 Neurofibrillary tangles; LUSC cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg10207240 chr12:122356781 WDR66 0.43 6.27 0.32 1.11e-9 Mean corpuscular volume; LUSC cis rs7428 0.545 rs1053561 chr2:85546052 A/G cg24342717 chr2:85555507 TGOLN2 -0.74 -11.94 -0.55 1.31e-27 Ear protrusion; LUSC cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 7.23 0.37 3.29e-12 Personality dimensions; LUSC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs7605827 0.930 rs2287260 chr2:15624810 T/C cg19274914 chr2:15703543 NA 0.45 8.57 0.42 3.81e-16 Educational attainment (years of education); LUSC cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg13736514 chr6:26305472 NA -0.47 -9.33 -0.45 1.55e-18 Educational attainment; LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg27588902 chr6:42928151 GNMT -0.28 -6.04 -0.31 4.22e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.95 -0.36 1.98e-11 Menopause (age at onset); LUSC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg04414720 chr1:150670196 GOLPH3L 0.51 7.91 0.4 3.9e-14 Melanoma; LUSC cis rs6500602 0.563 rs917305 chr16:4440593 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 6.84 0.35 3.77e-11 Schizophrenia; LUSC cis rs78579285 0.545 rs113385327 chr16:88785242 A/C cg01900006 chr16:88814613 FAM38A 0.54 6.13 0.32 2.49e-9 Joint mobility (Beighton score); LUSC cis rs9650315 0.714 rs28447646 chr8:57183102 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs7215564 0.818 rs34929663 chr17:78617212 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.05 0.31 3.91e-9 Myopia (pathological); LUSC cis rs709400 0.628 rs11621510 chr14:103869620 T/C cg12935359 chr14:103987150 CKB -0.55 -8.49 -0.42 7e-16 Body mass index; LUSC cis rs11971779 0.648 rs6967836 chr7:139079944 C/G cg07862535 chr7:139043722 LUC7L2 0.57 7.27 0.37 2.49e-12 Diisocyanate-induced asthma; LUSC cis rs859767 0.741 rs7602801 chr2:135363870 A/G cg12500956 chr2:135428796 TMEM163 -0.28 -6.23 -0.32 1.42e-9 Neuroticism; LUSC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg18876405 chr7:65276391 NA -0.58 -9.44 -0.46 6.72e-19 Aortic root size; LUSC trans rs2392780 0.638 rs283704 chr8:128315582 A/G cg10897648 chr18:56338258 MALT1 -0.43 -6.45 -0.33 3.87e-10 Breast cancer (early onset); LUSC cis rs6547741 1.000 rs1080060 chr2:27768808 T/A cg12559939 chr2:27858050 GPN1 0.41 6.38 0.33 5.85e-10 Oral cavity cancer; LUSC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg13010199 chr12:38710504 ALG10B -0.58 -9.17 -0.45 4.95e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg19774624 chr17:42201019 HDAC5 -0.55 -8.68 -0.43 1.76e-16 Bone mineral density (hip);Bone mineral density; LUSC cis rs7937682 0.924 rs6589244 chr11:111534333 T/C cg19812747 chr11:111475976 SIK2 -0.45 -6.24 -0.32 1.31e-9 Primary sclerosing cholangitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21859597 chr1:115323395 SIKE1 -0.39 -5.99 -0.31 5.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg11608241 chr8:8085544 FLJ10661 -0.4 -5.86 -0.31 1.09e-8 Joint mobility (Beighton score); LUSC trans rs877282 0.947 rs7904978 chr10:768078 C/T cg22713356 chr15:30763199 NA 1.1 15.68 0.65 6.69e-42 Uric acid levels; LUSC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg20684491 chr1:25596433 NA 0.36 5.69 0.3 2.73e-8 Erythrocyte sedimentation rate; LUSC cis rs2692947 0.526 rs4907225 chr2:96576670 C/T cg22654517 chr2:96458247 NA 0.37 6.97 0.36 1.66e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7937682 0.883 rs12366001 chr11:111433916 A/G cg09085632 chr11:111637200 PPP2R1B 0.98 14.46 0.62 3.84e-37 Primary sclerosing cholangitis; LUSC trans rs61931739 0.534 rs11053016 chr12:34104372 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg14784868 chr12:69753453 YEATS4 0.82 13.98 0.61 2.89e-35 Blood protein levels; LUSC cis rs9399401 0.925 rs6929442 chr6:142742659 T/C cg03128060 chr6:142623767 GPR126 0.33 6.05 0.31 3.91e-9 Chronic obstructive pulmonary disease; LUSC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.56 -0.34 2.11e-10 Bipolar disorder and schizophrenia; LUSC cis rs10740039 0.842 rs1442541 chr10:62386043 C/T cg18175470 chr10:62150864 ANK3 -0.47 -7.0 -0.36 1.42e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7937890 0.681 rs4756784 chr11:14270904 G/A cg19336497 chr11:14380999 RRAS2 0.41 7.23 0.37 3.27e-12 Mitochondrial DNA levels; LUSC cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg16339924 chr4:17578868 LAP3 0.62 9.39 0.46 9.43e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg10018233 chr7:150070692 REPIN1 0.34 6.01 0.31 4.93e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg11764359 chr7:65958608 NA -0.68 -10.39 -0.49 4.22e-22 Aortic root size; LUSC cis rs259282 0.583 rs12981373 chr19:33108189 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.66 9.93 0.48 1.58e-20 Schizophrenia; LUSC cis rs11252926 0.673 rs553326 chr10:749238 G/T cg18196295 chr10:418757 DIP2C -0.41 -6.4 -0.33 5.27e-10 Psychosis in Alzheimer's disease; LUSC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg20476274 chr7:133979776 SLC35B4 0.82 14.95 0.63 4.64e-39 Mean platelet volume; LUSC cis rs12474201 0.862 rs7562173 chr2:46976217 C/G cg06386533 chr2:46925753 SOCS5 -0.66 -9.7 -0.47 9.07e-20 Height; LUSC trans rs35110281 0.776 rs2838316 chr21:44990036 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 11.06 0.52 1.94e-24 Mean corpuscular volume; LUSC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 3.01e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4889855 0.556 rs11150863 chr17:78532321 A/G cg16591659 chr17:78472290 NA -0.32 -5.9 -0.31 8.98e-9 Fractional excretion of uric acid; LUSC trans rs3889199 0.779 rs12746759 chr1:59667150 G/A cg24327262 chr19:46929907 NA -0.39 -6.09 -0.32 3.09e-9 Pulse pressure; LUSC cis rs8060686 0.698 rs8044558 chr16:68210165 T/C cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs1532331 0.966 rs6870418 chr5:43111526 C/T cg02477305 chr13:23993013 SACS 0.35 5.98 0.31 5.68e-9 Menarche (age at onset); LUSC cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg27279351 chr12:120934652 DYNLL1 0.58 7.81 0.39 7.23e-14 High light scatter reticulocyte count; LUSC cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg00409905 chr10:38381863 ZNF37A 0.35 6.07 0.32 3.56e-9 Extrinsic epigenetic age acceleration; LUSC cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg26061582 chr7:22766209 IL6 0.41 5.92 0.31 8.09e-9 Lung cancer; LUSC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs16867321 0.588 rs1919156 chr2:181456978 C/T cg23363182 chr2:181467187 NA -0.6 -9.72 -0.47 8.06e-20 Obesity; LUSC cis rs61931739 0.635 rs1525895 chr12:33966496 A/G cg06521331 chr12:34319734 NA -0.41 -6.87 -0.35 3.07e-11 Morning vs. evening chronotype; LUSC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg16524733 chr11:117070046 TAGLN -0.44 -7.67 -0.39 1.93e-13 Blood protein levels; LUSC trans rs208520 0.874 rs208512 chr6:66943869 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -13.87 -0.6 7.31e-35 Exhaled nitric oxide output; LUSC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg13395646 chr4:1353034 KIAA1530 -0.48 -7.26 -0.37 2.75e-12 Longevity; LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg07701084 chr6:150067640 NUP43 0.53 7.99 0.4 2.25e-14 Lung cancer; LUSC cis rs73206853 0.764 rs56127909 chr12:110833763 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16755598 chr14:50100815 C14orf104 -0.45 -6.02 -0.31 4.55e-9 Bipolar disorder and schizophrenia; LUSC cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg01097406 chr16:89675127 NA 0.41 7.83 0.39 6.4e-14 Vitiligo; LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg22920501 chr2:26401640 FAM59B 0.77 11.26 0.52 3.73e-25 Gut microbiome composition (summer); LUSC cis rs1697139 0.935 rs1627990 chr5:66513326 C/T cg11553311 chr5:66541588 NA 0.32 6.14 0.32 2.33e-9 Breast cancer; LUSC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg03060546 chr3:49711283 APEH 0.71 12.0 0.55 7.94e-28 Resting heart rate; LUSC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg08499158 chr17:42289980 UBTF -0.39 -6.15 -0.32 2.21e-9 Total body bone mineral density; LUSC trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg15556689 chr8:8085844 FLJ10661 0.57 8.54 0.42 4.71e-16 Retinal vascular caliber; LUSC cis rs6558174 0.965 rs2009212 chr8:22491496 G/A cg03733263 chr8:22462867 KIAA1967 0.47 6.31 0.33 8.94e-10 Breast cancer; LUSC cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg06808227 chr14:105710500 BRF1 -0.68 -10.38 -0.49 4.68e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs858239 0.539 rs10270695 chr7:23188988 C/T cg23682824 chr7:23144976 KLHL7 -0.42 -5.88 -0.31 1.01e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs12208915 0.945 rs12201183 chr6:79570120 A/G cg05283184 chr6:79620031 NA 0.46 6.0 0.31 5.19e-9 Left atrial antero-posterior diameter; LUSC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs9398803 0.865 rs2326451 chr6:126811928 A/T cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 2.01e-9 Male-pattern baldness; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg25461163 chr5:72112466 TNPO1 0.56 6.68 0.34 9.84e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs17685 0.712 rs869805 chr7:75688596 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.68 -0.39 1.74e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10072221 0.771 rs28386181 chr5:75703952 T/C cg03132911 chr5:75698732 IQGAP2 0.35 5.95 0.31 6.96e-9 Mean platelet volume; LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.42 5.76 0.3 1.9e-8 Gut microbiome composition (summer); LUSC cis rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05901451 chr6:126070800 HEY2 0.57 8.48 0.42 7.3e-16 Endometrial cancer; LUSC cis rs7589342 0.839 rs35812588 chr2:106432201 C/T cg14210321 chr2:106509881 NCK2 -0.53 -7.92 -0.4 3.47e-14 Addiction; LUSC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg02423579 chr7:2872169 GNA12 -0.44 -6.43 -0.33 4.29e-10 Height; LUSC cis rs2455601 0.638 rs11042148 chr11:9008674 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -6.81 -0.35 4.57e-11 Schizophrenia; LUSC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg11344533 chr11:111475393 SIK2 -0.49 -6.8 -0.35 4.8e-11 Primary sclerosing cholangitis; LUSC cis rs240764 0.658 rs11155659 chr6:101222568 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.48 -0.33 3.29e-10 Neuroticism; LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.61 0.54 2.12e-26 Alzheimer's disease; LUSC cis rs7605827 0.930 rs6431707 chr2:15638165 A/T cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.34e-18 Educational attainment (years of education); LUSC cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg05347473 chr6:146136440 FBXO30 -0.41 -6.94 -0.36 2.01e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.74 -0.39 1.21e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs10789491 0.767 rs1816730 chr1:47207346 T/C cg15501359 chr1:47185051 KIAA0494 0.78 10.13 0.48 3.24e-21 Response to hepatitis C treatment; LUSC cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg26898376 chr11:64110657 CCDC88B 0.33 6.2 0.32 1.67e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7911264 0.739 rs7914814 chr10:94382950 A/G cg25093409 chr10:94429542 NA 0.35 6.06 0.31 3.61e-9 Inflammatory bowel disease; LUSC trans rs629535 0.862 rs598548 chr8:70032438 C/T cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs7945718 0.781 rs11022513 chr11:12840986 C/T cg25843174 chr11:12811716 TEAD1 -0.32 -7.41 -0.38 1.08e-12 Educational attainment (years of education); LUSC cis rs3857536 0.776 rs2040593 chr6:66944076 G/A cg07460842 chr6:66804631 NA -0.46 -6.41 -0.33 4.93e-10 Blood trace element (Cu levels); LUSC trans rs6601327 0.571 rs7820675 chr8:9647748 C/G cg08975724 chr8:8085496 FLJ10661 0.45 6.5 0.34 2.97e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg11965913 chr1:205819406 PM20D1 -0.47 -7.15 -0.36 5.38e-12 Parkinson's disease; LUSC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg23758822 chr17:41437982 NA 1.02 20.24 0.74 5.16e-60 Menopause (age at onset); LUSC cis rs6977660 0.714 rs12700075 chr7:19791476 G/T cg05791153 chr7:19748676 TWISTNB 0.79 8.39 0.42 1.38e-15 Thyroid stimulating hormone; LUSC cis rs4843185 0.731 rs3815795 chr16:85712105 A/G cg26571870 chr16:85723150 GINS2 0.31 5.73 0.3 2.23e-8 Platelet distribution width; LUSC cis rs17021463 0.726 rs62320444 chr4:95261251 C/T cg11021082 chr4:95130006 SMARCAD1 0.37 6.9 0.35 2.59e-11 Testicular germ cell tumor; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg27094323 chr7:1216898 NA -0.39 -6.66 -0.34 1.13e-10 Longevity;Endometriosis; LUSC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg12257692 chr3:49977190 RBM6 -0.25 -6.64 -0.34 1.28e-10 Intelligence (multi-trait analysis); LUSC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg18252515 chr7:66147081 NA -1.23 -14.27 -0.62 2.16e-36 Diabetic kidney disease; LUSC cis rs2760061 0.583 rs708110 chr1:228190805 T/A cg18477163 chr1:228402036 OBSCN 0.57 9.52 0.46 3.7e-19 Diastolic blood pressure; LUSC cis rs9300255 0.537 rs1618679 chr12:123650714 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.14 -0.32 2.38e-9 Neutrophil percentage of white cells; LUSC cis rs8072100 0.782 rs62074054 chr17:45771816 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.4 -6.2 -0.32 1.64e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs637571 0.726 rs526631 chr11:65681965 T/G cg02427764 chr11:65769310 BANF1;EIF1AD -0.4 -5.67 -0.3 3.07e-8 Eosinophil percentage of white cells; LUSC cis rs9341808 0.690 rs9343970 chr6:80881289 C/G cg08355045 chr6:80787529 NA 0.58 10.07 0.48 5.31e-21 Sitting height ratio; LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg14433983 chr11:636460 DRD4 -0.35 -5.85 -0.31 1.15e-8 Systemic lupus erythematosus; LUSC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg17376030 chr22:41985996 PMM1 -0.47 -5.84 -0.3 1.25e-8 Cannabis dependence symptom count; LUSC cis rs10788972 0.510 rs665817 chr1:54469948 T/G cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Parkinson disease and lewy body pathology; LUSC cis rs1971762 0.542 rs12303370 chr12:54091807 A/C cg23533419 chr12:54090519 NA -0.36 -5.92 -0.31 8.13e-9 Height; LUSC cis rs2050392 1.000 rs2250714 chr10:30697396 G/C cg18806716 chr10:30721971 MAP3K8 -0.46 -7.44 -0.38 8.6e-13 Inflammatory bowel disease; LUSC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg01657329 chr11:68192670 LRP5 -0.44 -6.59 -0.34 1.73e-10 Total body bone mineral density; LUSC cis rs9341808 0.754 rs6918172 chr6:81019242 A/G cg08355045 chr6:80787529 NA 0.55 9.73 0.47 7.16e-20 Sitting height ratio; LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.87 -12.16 -0.55 2.04e-28 Platelet count; LUSC cis rs11190604 1.000 rs11190541 chr10:102203071 A/G cg07080220 chr10:102295463 HIF1AN 0.65 8.72 0.43 1.3e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7712401 1.000 rs7712401 chr5:122374459 C/T cg19077854 chr5:122220652 SNX24 0.32 7.03 0.36 1.14e-11 Mean platelet volume; LUSC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg03929089 chr4:120376271 NA -0.96 -15.51 -0.65 3.14e-41 Coronary artery disease; LUSC cis rs11229555 0.645 rs12291551 chr11:58176915 T/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg00121533 chr1:75199117 CRYZ;TYW3 0.5 7.91 0.4 3.76e-14 Resistin levels; LUSC cis rs1348850 0.567 rs3770005 chr2:178528874 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.42 5.72 0.3 2.41e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13223928 0.511 rs11773338 chr7:3144508 T/C cg19214707 chr7:3157722 NA -0.46 -9.11 -0.45 7.85e-18 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs911555 0.723 rs7144010 chr14:103869869 G/A cg24130564 chr14:104152367 KLC1 0.44 6.25 0.32 1.24e-9 Intelligence (multi-trait analysis); LUSC cis rs1577917 1.000 rs12663690 chr6:86640162 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.43 6.19 0.32 1.76e-9 Response to antipsychotic treatment; LUSC cis rs12681287 0.752 rs10435564 chr8:87266239 T/C cg27223183 chr8:87520930 FAM82B -0.45 -5.72 -0.3 2.33e-8 Caudate activity during reward; LUSC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg06740227 chr12:86229804 RASSF9 0.39 6.25 0.32 1.23e-9 Major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10109876 chr10:61122470 FAM13C -0.45 -6.0 -0.31 5.02e-9 Bipolar disorder and schizophrenia; LUSC cis rs4356932 0.715 rs9992952 chr4:76898174 A/C cg00809888 chr4:76862425 NAAA 0.37 5.91 0.31 8.4e-9 Blood protein levels; LUSC cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg24558204 chr6:135376177 HBS1L 0.46 6.78 0.35 5.52e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.899 rs6944096 chr7:148870026 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.3 0.33 9.33e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12711979 0.729 rs6714956 chr2:3820454 T/C cg17052675 chr2:3827356 NA -0.57 -11.28 -0.53 3.18e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs7248779 0.512 rs12610522 chr19:2413228 C/T cg22729335 chr19:2427816 TIMM13 1.04 18.49 0.71 4.53e-53 Cortisol levels (saliva); LUSC cis rs4631830 0.657 rs2611502 chr10:51500301 A/G cg20129853 chr10:51489980 NA -0.37 -7.67 -0.39 1.93e-13 Prostate-specific antigen levels; LUSC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg18904891 chr8:8559673 CLDN23 0.61 8.13 0.41 8.56e-15 Obesity-related traits; LUSC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg09044154 chr16:88155775 NA -0.56 -7.59 -0.38 3.22e-13 Menopause (age at onset); LUSC cis rs4792901 0.765 rs9894019 chr17:41565505 T/G cg22562494 chr17:41607896 ETV4 -0.34 -6.53 -0.34 2.45e-10 Dupuytren's disease; LUSC cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg26647111 chr11:31128758 NA -0.41 -5.89 -0.31 9.29e-9 Red blood cell count; LUSC cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg24642439 chr20:33292090 TP53INP2 -0.52 -7.94 -0.4 3.08e-14 Glomerular filtration rate (creatinine); LUSC cis rs68170813 0.559 rs6964798 chr7:106933013 C/G cg02696742 chr7:106810147 HBP1 -0.65 -9.82 -0.47 3.55e-20 Coronary artery disease; LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 11.08 0.52 1.71e-24 Alzheimer's disease; LUSC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg21724239 chr8:58056113 NA 0.75 8.01 0.4 1.93e-14 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg05347473 chr6:146136440 FBXO30 0.53 9.0 0.44 1.73e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9534288 0.797 rs7996875 chr13:46612836 C/T cg15192986 chr13:46630673 CPB2 0.65 10.74 0.51 2.67e-23 Blood protein levels; LUSC cis rs72901758 0.661 rs56683270 chr17:76247827 T/C cg26068271 chr17:76253126 NA 0.52 9.44 0.46 6.54e-19 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg03526776 chr6:41159608 TREML2 0.33 6.33 0.33 7.97e-10 Alzheimer's disease (late onset); LUSC trans rs7615952 0.599 rs6779141 chr3:125709995 A/T cg07211511 chr3:129823064 LOC729375 -0.8 -10.65 -0.5 5.31e-23 Blood pressure (smoking interaction); LUSC cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg08997352 chr12:9597637 DDX12 -0.72 -11.85 -0.54 2.73e-27 Breast size; LUSC cis rs4704187 0.617 rs2035192 chr5:74407231 T/A cg03227963 chr5:74354835 NA 0.32 6.87 0.35 3.09e-11 Response to amphetamines; LUSC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg20203395 chr5:56204925 C5orf35 -0.51 -7.46 -0.38 7.62e-13 Coronary artery disease; LUSC cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.35 0.53 1.79e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs12200782 0.872 rs59438701 chr6:26412527 C/T cg11837749 chr1:55047332 ACOT11 0.52 6.28 0.32 1.06e-9 Small cell lung carcinoma; LUSC cis rs2274273 0.662 rs67588230 chr14:55667030 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.56 0.46 2.77e-19 Protein biomarker; LUSC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg27124370 chr19:33622961 WDR88 0.59 8.26 0.41 3.36e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs17685 0.740 rs2286821 chr7:75611355 C/T cg19862616 chr7:65841803 NCRNA00174 -0.94 -15.25 -0.64 3.13e-40 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6121246 0.529 rs6060145 chr20:30178631 T/C cg18721089 chr20:30220636 NA -0.41 -6.08 -0.32 3.29e-9 Mean corpuscular hemoglobin; LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg10609677 chr17:41278573 BRCA1;NBR2 -0.36 -5.87 -0.31 1.05e-8 Menopause (age at onset); LUSC cis rs9517302 0.615 rs2274053 chr13:99098318 C/T cg22223119 chr13:99095684 FARP1 -0.71 -9.85 -0.47 2.88e-20 Obesity-related traits; LUSC cis rs6542838 0.703 rs7593332 chr2:99467991 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.63 -0.34 1.32e-10 Fear of minor pain; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07920148 chr11:33397821 NA -0.37 -6.46 -0.33 3.76e-10 Electrocardiographic conduction measures; LUSC cis rs897984 0.683 rs13337900 chr16:30822409 G/A cg02466173 chr16:30829666 NA -0.68 -16.26 -0.66 3.38e-44 Dementia with Lewy bodies; LUSC cis rs3936840 0.964 rs10150698 chr14:102977876 A/G cg18135206 chr14:102964638 TECPR2 0.58 8.96 0.44 2.29e-17 Plateletcrit; LUSC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg26061582 chr7:22766209 IL6 0.48 6.91 0.35 2.51e-11 Lung cancer; LUSC cis rs73206853 0.764 rs60027620 chr12:111103669 T/G cg12870014 chr12:110450643 ANKRD13A 0.7 7.54 0.38 4.44e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.15e-9 Prudent dietary pattern; LUSC cis rs9309473 1.000 rs11899902 chr2:73631564 G/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.83 -0.35 3.95e-11 Metabolite levels; LUSC cis rs78707713 0.560 rs12784882 chr10:71230334 C/G cg12610070 chr10:71211762 TSPAN15 -0.49 -9.58 -0.46 2.31e-19 Venous thromboembolism; LUSC cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg21535247 chr6:8435926 SLC35B3 0.6 9.36 0.46 1.23e-18 Motion sickness; LUSC cis rs7568458 0.840 rs2886722 chr2:85742297 C/T cg17127132 chr2:85788382 GGCX -0.47 -7.53 -0.38 4.68e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg10360139 chr7:1886902 MAD1L1 -0.4 -6.13 -0.32 2.54e-9 Bipolar disorder and schizophrenia; LUSC cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg09479241 chr17:27052676 TLCD1 0.43 5.96 0.31 6.29e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7178572 1.000 rs965480 chr15:77781926 A/G cg22256960 chr15:77711686 NA -0.55 -9.25 -0.45 2.74e-18 Type 2 diabetes; LUSC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg21926612 chr6:163149169 PACRG;PARK2 1.19 15.61 0.65 1.22e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg17724175 chr1:150552817 MCL1 0.37 6.73 0.35 7.44e-11 Tonsillectomy; LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg02475777 chr4:1388615 CRIPAK 0.44 6.61 0.34 1.55e-10 Obesity-related traits; LUSC cis rs9814567 0.896 rs11915964 chr3:134348930 A/C cg15484384 chr3:134203672 ANAPC13;CEP63 0.3 5.77 0.3 1.78e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs3764563 0.935 rs4807958 chr19:15718042 T/C cg20725493 chr19:15740067 CYP4F8 -0.67 -6.58 -0.34 1.85e-10 Inflammatory biomarkers; LUSC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs7202877 0.706 rs247437 chr16:75431275 T/G cg03315344 chr16:75512273 CHST6 -0.41 -5.98 -0.31 5.76e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs950169 0.580 rs4603535 chr15:85173872 C/T cg17507749 chr15:85114479 UBE2QP1 0.58 7.38 0.37 1.28e-12 Schizophrenia; LUSC cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg24130564 chr14:104152367 KLC1 -0.47 -6.82 -0.35 4.31e-11 Intelligence (multi-trait analysis); LUSC cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg01849466 chr14:104193079 ZFYVE21 0.58 9.49 0.46 4.59e-19 Schizophrenia; LUSC cis rs4631830 0.900 rs7920517 chr10:51532621 G/A cg16070123 chr10:51489643 NA -0.51 -8.18 -0.41 6.22e-15 Prostate-specific antigen levels; LUSC cis rs7089973 0.604 rs11196947 chr10:116601372 G/A cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2652834 0.718 rs2652836 chr15:63396301 A/G cg05507819 chr15:63340323 TPM1 -0.51 -6.65 -0.34 1.18e-10 HDL cholesterol; LUSC cis rs2191566 0.576 rs381759 chr19:44495145 A/G cg18700516 chr19:44507157 ZNF230 -0.4 -5.65 -0.3 3.42e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg02175503 chr12:58329896 NA 0.47 6.8 0.35 4.86e-11 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg18190219 chr22:46762943 CELSR1 -0.56 -6.45 -0.33 3.83e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs2439831 0.850 rs28413704 chr15:44148427 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.83 0.43 6.09e-17 Lung cancer in ever smokers; LUSC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg21951975 chr1:209979733 IRF6 -0.54 -6.99 -0.36 1.47e-11 Cleft lip with or without cleft palate; LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg00166722 chr3:10149974 C3orf24 0.62 7.77 0.39 1e-13 Alzheimer's disease; LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg00106254 chr7:1943704 MAD1L1 -0.4 -5.77 -0.3 1.81e-8 Bipolar disorder and schizophrenia; LUSC cis rs1670533 0.818 rs585735 chr4:1080391 G/C cg27284194 chr4:1044797 NA 0.58 8.71 0.43 1.4e-16 Recombination rate (females); LUSC cis rs4654899 0.785 rs9426736 chr1:21505931 T/G cg01072550 chr1:21505969 NA -0.54 -8.22 -0.41 4.67e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7572733 0.534 rs2574832 chr2:198704818 T/G cg00792783 chr2:198669748 PLCL1 0.43 5.7 0.3 2.6e-8 Dermatomyositis; LUSC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2562456 0.833 rs2968076 chr19:21637101 C/T cg00806126 chr19:22604979 ZNF98 0.38 5.94 0.31 7.34e-9 Pain; LUSC cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC trans rs836788 0.570 rs26783 chr5:80050103 T/A cg27031367 chr8:145510315 BOP1 -0.37 -6.07 -0.32 3.42e-9 Glomerular filtration rate (creatinine); LUSC cis rs1950626 0.699 rs12880855 chr14:101468382 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.35 5.69 0.3 2.72e-8 Pelvic organ prolapse (moderate/severe); LUSC trans rs8072100 0.790 rs11656856 chr17:45714671 C/T cg03886242 chr7:26192032 NFE2L3 0.4 6.34 0.33 7.37e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs727505 0.754 rs56012154 chr7:124781250 A/G cg23710748 chr7:124431027 NA -0.4 -7.02 -0.36 1.24e-11 Lewy body disease; LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg08280861 chr8:58055591 NA 0.54 5.87 0.31 1.04e-8 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.65 -0.3 3.35e-8 Life satisfaction; LUSC cis rs559928 0.597 rs11600667 chr11:63976183 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.48 0.38 6.74e-13 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg04352962 chr1:209979756 IRF6 0.54 6.3 0.33 9.64e-10 Cleft lip with or without cleft palate; LUSC cis rs11997175 0.545 rs4428637 chr8:33666944 T/G ch.8.33884649F chr8:33765107 NA 0.51 7.33 0.37 1.79e-12 Body mass index; LUSC trans rs17685 0.753 rs7788763 chr7:75651665 T/C cg26594503 chr5:96210394 ERAP2 0.4 6.03 0.31 4.44e-9 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs9860340 0.730 rs57108523 chr3:87643655 A/G cg03644585 chr7:884825 UNC84A 0.42 6.05 0.31 3.9e-9 Electroencephalographic traits in alcoholism; LUSC cis rs9486715 0.867 rs4598081 chr6:96975227 A/G cg06623918 chr6:96969491 KIAA0776 0.95 17.74 0.7 4.5e-50 Headache; LUSC cis rs740160 0.510 rs6973408 chr7:98900853 A/G cg24650262 chr7:98904301 NA 0.61 6.8 0.35 4.93e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs7927592 0.956 rs10896341 chr11:68313180 G/A cg16797656 chr11:68205561 LRP5 0.38 6.23 0.32 1.4e-9 Total body bone mineral density; LUSC trans rs11098499 0.954 rs11940028 chr4:120411907 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.58 0.34 1.81e-10 Corneal astigmatism; LUSC cis rs61931739 0.500 rs11053208 chr12:34460029 A/G cg06521331 chr12:34319734 NA -0.42 -6.98 -0.36 1.6e-11 Morning vs. evening chronotype; LUSC trans rs979233 0.502 rs276247 chr5:42062298 A/G cg07010552 chr17:7358735 CHRNB1 -0.41 -6.02 -0.31 4.72e-9 Systemic lupus erythematosus; LUSC cis rs12999616 1.000 rs12999616 chr2:98324381 C/T cg26665480 chr2:98280029 ACTR1B 0.65 6.96 0.36 1.8e-11 Colorectal cancer; LUSC cis rs7681440 0.904 rs6532192 chr4:90764131 G/A cg01966878 chr4:90757139 SNCA -0.36 -6.22 -0.32 1.52e-9 Dementia with Lewy bodies; LUSC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg27124370 chr19:33622961 WDR88 0.61 8.6 0.43 3.19e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.63 -8.81 -0.43 7.13e-17 Multiple sclerosis; LUSC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.65 -0.34 1.17e-10 Mean platelet volume; LUSC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC cis rs826838 0.651 rs12367384 chr12:38618460 G/T cg26384229 chr12:38710491 ALG10B 0.77 12.06 0.55 4.9e-28 Heart rate; LUSC cis rs1178968 0.818 rs2262777 chr7:72786490 A/T cg25889504 chr7:72793014 NA 0.61 7.83 0.39 6.55e-14 Triglyceride levels; LUSC cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg22782873 chr19:19639568 YJEFN3 -0.53 -6.45 -0.33 3.94e-10 Bipolar disorder; LUSC cis rs10761482 0.813 rs10740026 chr10:62112842 G/A cg18175470 chr10:62150864 ANK3 -0.51 -7.25 -0.37 2.99e-12 Schizophrenia; LUSC cis rs2230307 0.536 rs12733952 chr1:100611571 A/G cg24955406 chr1:100503596 HIAT1 0.59 6.42 0.33 4.65e-10 Carotid intima media thickness; LUSC cis rs9650315 0.733 rs13251457 chr8:57202902 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.34 0.37 1.64e-12 Height; LUSC cis rs8056893 0.714 rs1465470 chr16:68397909 A/G cg02226672 chr16:68398533 SMPD3 0.32 5.75 0.3 2.03e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs67460515 0.563 rs13256 chr3:160796505 G/A cg03342759 chr3:160939853 NMD3 -0.45 -6.03 -0.31 4.41e-9 Parkinson's disease; LUSC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg03517284 chr6:25882590 NA -0.47 -8.98 -0.44 1.97e-17 Blood metabolite levels; LUSC cis rs7267979 1.000 rs4815409 chr20:25346697 C/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25427524 chr10:38739819 LOC399744 -0.78 -14.67 -0.63 5.73e-38 Breast cancer; LUSC cis rs12142240 0.698 rs17361950 chr1:46864150 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.37 0.42 1.6e-15 Menopause (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04570466 chr21:40752046 WRB 0.74 6.0 0.31 5.25e-9 Cognitive performance; LUSC cis rs17125944 0.615 rs8003334 chr14:53374967 C/T cg00686598 chr14:53173677 PSMC6 0.7 6.37 0.33 6.18e-10 Alzheimer's disease (late onset); LUSC cis rs12545109 0.800 rs2582401 chr8:57401656 A/G cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.16e-10 Obesity-related traits; LUSC cis rs12190007 0.547 rs1018559 chr6:169854176 A/G cg15038512 chr6:170123185 PHF10 -0.44 -7.0 -0.36 1.41e-11 Obesity-related traits; LUSC trans rs17266958 1.000 rs62574474 chr9:83265810 C/T cg01905489 chr1:26616534 UBXN11 -0.61 -6.27 -0.32 1.15e-9 Preschool internalizing problems; LUSC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 2.94e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.98 -0.36 1.55e-11 Blood metabolite levels; LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg00814883 chr7:100076585 TSC22D4 -0.69 -9.31 -0.45 1.71e-18 Platelet count; LUSC cis rs2251381 0.520 rs873651 chr21:30781848 G/A cg08807101 chr21:30365312 RNF160 0.64 9.87 0.48 2.51e-20 Selective IgA deficiency; LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg08736216 chr1:53307985 ZYG11A -0.29 -5.98 -0.31 5.85e-9 Monocyte count; LUSC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg11645453 chr3:52864694 ITIH4 0.35 8.19 0.41 5.54e-15 Electroencephalogram traits; LUSC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.05 0.4 1.52e-14 Parkinson's disease; LUSC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg16228356 chr17:43848958 NA 0.28 6.42 0.33 4.57e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11636714 chr8:42128950 IKBKB -0.47 -6.4 -0.33 5.29e-10 Bipolar disorder and schizophrenia; LUSC cis rs2224391 0.628 rs2773309 chr6:5248916 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.5 -0.34 2.92e-10 Height; LUSC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg02463440 chr8:22132932 PIWIL2 0.44 8.32 0.41 2.32e-15 Hypertriglyceridemia; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg11645453 chr3:52864694 ITIH4 0.37 8.57 0.42 3.91e-16 Bipolar disorder; LUSC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg26314531 chr2:26401878 FAM59B -0.65 -9.19 -0.45 4.33e-18 Gut microbiome composition (summer); LUSC cis rs12760731 0.565 rs16828608 chr1:178129899 C/T cg00404053 chr1:178313656 RASAL2 0.61 6.45 0.33 3.9e-10 Obesity-related traits; LUSC cis rs826838 0.586 rs1843903 chr12:38627524 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.77 0.51 2.03e-23 Heart rate; LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.3e-11 Monocyte count; LUSC cis rs9309473 1.000 rs11903916 chr2:73815328 G/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.95 -0.36 1.97e-11 Metabolite levels; LUSC cis rs56235845 0.665 rs4976685 chr5:176766177 C/T cg17261708 chr5:176794207 RGS14 -0.34 -5.91 -0.31 8.55e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs1670533 1.000 rs6852558 chr4:1059944 C/T cg02018176 chr4:1364513 KIAA1530 0.44 6.03 0.31 4.23e-9 Recombination rate (females); LUSC cis rs3540 0.597 rs10152221 chr15:91047664 A/G cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.82 -0.3 1.36e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4268898 0.662 rs17733015 chr2:24509370 A/G cg06627628 chr2:24431161 ITSN2 -0.85 -12.84 -0.57 6.18e-31 Asthma; LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.67 0.39 1.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11030122 0.702 rs10835407 chr11:3993231 C/T cg18678763 chr11:4115507 RRM1 0.46 6.03 0.31 4.3e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.47 7.3 0.37 2.13e-12 Colorectal cancer; LUSC cis rs8058578 0.945 rs34480360 chr16:30798689 G/A cg02466173 chr16:30829666 NA -0.6 -10.81 -0.51 1.49e-23 Multiple myeloma; LUSC cis rs6066835 0.867 rs6095271 chr20:47356176 C/G cg18078177 chr20:47281410 PREX1 0.76 6.72 0.35 7.74e-11 Multiple myeloma; LUSC cis rs6840360 0.571 rs62327271 chr4:152535916 A/G cg22705602 chr4:152727874 NA -0.32 -6.46 -0.33 3.59e-10 Intelligence (multi-trait analysis); LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg02136620 chr5:178986620 RUFY1 -0.47 -7.62 -0.38 2.58e-13 Lung cancer; LUSC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg03609598 chr5:56110824 MAP3K1 -0.4 -5.86 -0.31 1.1e-8 Initial pursuit acceleration; LUSC trans rs7939886 0.764 rs7113688 chr11:55946865 C/T cg15704280 chr7:45808275 SEPT13 0.89 6.88 0.35 3e-11 Myopia (pathological); LUSC cis rs7824557 0.751 rs2099456 chr8:11127001 A/C cg21775007 chr8:11205619 TDH 0.61 9.7 0.47 9.49e-20 Retinal vascular caliber; LUSC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.27 0.52 3.58e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg16606324 chr3:10149918 C3orf24 0.58 8.38 0.42 1.54e-15 Alzheimer's disease; LUSC trans rs6502050 0.528 rs12942561 chr17:80116639 G/A cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.41e-10 Life satisfaction; LUSC cis rs3740713 1.000 rs76599129 chr11:18471627 T/A cg07915343 chr11:18477680 LDHAL6A -0.54 -6.71 -0.34 8.43e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7202877 0.656 rs977986 chr16:75506696 T/G cg04384234 chr16:75411784 CFDP1 -0.65 -9.01 -0.44 1.61e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg11584989 chr19:19387371 SF4 0.59 7.07 0.36 8.9e-12 Bipolar disorder; LUSC cis rs11971779 0.648 rs4732367 chr7:139028102 A/C cg07862535 chr7:139043722 LUC7L2 0.53 6.55 0.34 2.17e-10 Diisocyanate-induced asthma; LUSC cis rs9807989 0.839 rs6749114 chr2:102967587 A/C cg03938978 chr2:103052716 IL18RAP 0.32 5.87 0.31 1.03e-8 Asthma; LUSC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg22823121 chr1:150693482 HORMAD1 0.56 8.47 0.42 8.01e-16 Melanoma; LUSC cis rs116139393 0.611 rs7792579 chr7:6765593 C/T cg09896999 chr7:6746977 ZNF12 -0.51 -7.05 -0.36 1.02e-11 Alzheimer's disease (APOE e4 interaction); LUSC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg07741184 chr6:167504864 NA 0.4 7.13 0.36 6.36e-12 Crohn's disease; LUSC cis rs11105298 0.891 rs10777184 chr12:89919568 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.42 -0.38 1.01e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs11098499 0.954 rs11734241 chr4:120416872 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs3540 0.557 rs11634314 chr15:91042066 A/C cg10434728 chr15:90938212 IQGAP1 -0.46 -9.23 -0.45 3.16e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg21699342 chr2:239360505 ASB1 -0.58 -10.79 -0.51 1.7e-23 Multiple system atrophy; LUSC cis rs6456156 0.742 rs1331299 chr6:167533467 A/G cg07741184 chr6:167504864 NA 0.36 6.62 0.34 1.43e-10 Primary biliary cholangitis; LUSC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg11871910 chr12:69753446 YEATS4 0.93 17.32 0.69 2.16e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs7584330 0.657 rs10211024 chr2:238353776 A/T cg16989719 chr2:238392110 NA -0.35 -5.98 -0.31 5.66e-9 Prostate cancer; LUSC cis rs16910800 0.953 rs73481422 chr11:23205174 T/C cg20040320 chr11:23191996 NA -0.44 -6.45 -0.33 3.85e-10 Cancer; LUSC cis rs701145 0.585 rs357482 chr3:153889855 A/G cg17054900 chr3:154042577 DHX36 0.7 6.82 0.35 4.38e-11 Coronary artery disease; LUSC cis rs2730245 0.527 rs2527187 chr7:158716912 T/C cg24397884 chr7:158709396 WDR60 -0.78 -9.15 -0.45 5.58e-18 Height; LUSC cis rs34311866 0.752 rs11725653 chr4:963397 C/T cg14530993 chr4:882597 GAK 0.66 6.59 0.34 1.76e-10 Parkinson's disease; LUSC cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg24130564 chr14:104152367 KLC1 -0.41 -5.87 -0.31 1.06e-8 Body mass index; LUSC cis rs1348850 0.958 rs4243390 chr2:178468008 G/A cg22681709 chr2:178499509 PDE11A -0.48 -8.7 -0.43 1.49e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg20887711 chr4:1340912 KIAA1530 -0.45 -6.91 -0.35 2.54e-11 Obesity-related traits; LUSC cis rs9549367 0.789 rs7317558 chr13:113893625 G/A cg18105134 chr13:113819100 PROZ -0.64 -9.42 -0.46 7.72e-19 Platelet distribution width; LUSC cis rs11690935 0.632 rs62183783 chr2:172865775 A/G cg13550731 chr2:172543902 DYNC1I2 0.55 8.41 0.42 1.2e-15 Schizophrenia; LUSC cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg12011299 chr4:100065546 ADH4 0.71 10.76 0.51 2.23e-23 Alcohol dependence; LUSC cis rs7615316 0.751 rs1825522 chr3:142003664 A/G cg16271453 chr3:142027066 XRN1 -0.41 -7.33 -0.37 1.76e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg03264133 chr6:25882463 NA -0.44 -7.63 -0.39 2.44e-13 Intelligence (multi-trait analysis); LUSC trans rs208520 0.526 rs9354370 chr6:66808209 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.2 25.23 0.81 2.31e-79 Exhaled nitric oxide output; LUSC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.64 8.74 0.43 1.15e-16 Multiple sclerosis; LUSC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg20406979 chr6:167373233 NA -0.25 -5.96 -0.31 6.31e-9 Crohn's disease; LUSC cis rs897080 0.515 rs1085450 chr2:44650698 A/T cg00619915 chr2:44497795 NA -0.39 -5.66 -0.3 3.26e-8 Height; LUSC cis rs8020912 0.504 rs3759577 chr14:103850963 C/T cg12935359 chr14:103987150 CKB 0.64 8.77 0.43 9.58e-17 Granulocyte percentage of myeloid white cells; LUSC cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs76878669 0.561 rs4930177 chr11:66120784 T/C cg24851651 chr11:66362959 CCS -0.36 -5.73 -0.3 2.25e-8 Educational attainment (years of education); LUSC cis rs4953076 0.573 rs6544746 chr2:44407985 C/T cg04920474 chr2:44395004 PPM1B 0.65 8.5 0.42 6.5e-16 Height; LUSC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg18876405 chr7:65276391 NA -0.7 -12.57 -0.57 6.28e-30 Aortic root size; LUSC cis rs1045529 0.524 rs34251783 chr8:8891376 T/C cg15556689 chr8:8085844 FLJ10661 -0.61 -9.75 -0.47 6.42e-20 Myopia;Myopia (pathological); LUSC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg23583168 chr7:148888333 NA -0.88 -16.59 -0.67 1.69e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9653442 0.527 rs11123812 chr2:100761548 T/C cg22139774 chr2:100720529 AFF3 -0.42 -7.26 -0.37 2.8e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs12286929 0.609 rs11602686 chr11:115100638 G/A cg04055981 chr11:115044050 NA 0.35 6.21 0.32 1.57e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12594515 0.967 rs11856523 chr15:45989495 C/T cg06207120 chr15:45996521 NA 0.38 5.9 0.31 8.97e-9 Waist circumference;Weight; LUSC cis rs4834770 1.000 rs4336213 chr4:120236469 G/T cg24375607 chr4:120327624 NA 0.41 5.85 0.3 1.19e-8 Blood protein levels; LUSC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg17366294 chr4:99064904 C4orf37 0.6 10.77 0.51 2.0500000000000001e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg26441486 chr22:50317300 CRELD2 0.47 7.07 0.36 9.01e-12 Schizophrenia; LUSC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg03526776 chr6:41159608 TREML2 0.32 6.37 0.33 6.32e-10 Alzheimer's disease (late onset); LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg00684032 chr4:1343700 KIAA1530 0.35 5.99 0.31 5.45e-9 Obesity-related traits; LUSC cis rs12145833 0.538 rs12026408 chr1:243366805 G/A cg02356786 chr1:243265016 LOC731275 0.72 6.62 0.34 1.46e-10 Obesity (early onset extreme); LUSC cis rs1055129 0.560 rs9891076 chr17:73911715 C/T cg17515076 chr17:73810948 UNK -0.4 -6.7 -0.34 8.97e-11 White matter hyperintensity burden; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25942691 chr19:36705733 ZNF565;ZNF146 0.46 6.53 0.34 2.4e-10 Mosquito bite size; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -10.36 -0.49 5.35e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs240764 0.658 rs10223467 chr6:101207589 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.3e-9 Neuroticism; LUSC cis rs11758351 1.000 rs16891378 chr6:26188864 A/G cg01420254 chr6:26195488 NA 0.65 7.16 0.36 5.29e-12 Gout;Renal underexcretion gout; LUSC cis rs208520 0.690 rs851465 chr6:66840293 G/A cg07460842 chr6:66804631 NA -1.14 -17.77 -0.7 3.45e-50 Exhaled nitric oxide output; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg01916446 chr16:87425777 FBXO31;MAP1LC3B 0.38 6.18 0.32 1.84e-9 Metabolite levels (Pyroglutamine); LUSC cis rs6429082 0.783 rs291385 chr1:235646613 T/C cg26050004 chr1:235667680 B3GALNT2 0.61 8.34 0.41 2.03e-15 Adiposity; LUSC trans rs3733585 0.699 rs6449159 chr4:9960498 G/A cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9300255 0.602 rs1716167 chr12:123651162 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 6.3 0.33 9.55e-10 Neutrophil percentage of white cells; LUSC cis rs7474896 0.537 rs2749588 chr10:38269457 C/G cg25427524 chr10:38739819 LOC399744 -0.43 -5.73 -0.3 2.25e-8 Obesity (extreme); LUSC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg03806693 chr22:41940476 POLR3H 0.92 12.56 0.57 6.67e-30 Crohn's disease;Inflammatory bowel disease; LUSC cis rs11583043 1.000 rs3861734 chr1:101489461 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.3 0.33 9.43e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs17818399 1.000 rs17818399 chr2:46826026 A/C cg02822958 chr2:46747628 ATP6V1E2 0.43 6.62 0.34 1.45e-10 Height; LUSC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.46 -0.38 7.61e-13 Height; LUSC cis rs2607426 0.681 rs79361456 chr19:41240363 A/C cg05508168 chr19:41255947 C19orf54;SNRPA 0.89 6.71 0.34 8.5e-11 Blood protein levels; LUSC cis rs870825 0.932 rs28594349 chr4:185574415 G/A cg04058563 chr4:185651563 MLF1IP 0.84 11.24 0.52 4.52e-25 Blood protein levels; LUSC cis rs2996428 0.601 rs10909804 chr1:3770929 A/G cg22529645 chr1:3704559 LRRC47 -0.36 -6.42 -0.33 4.59e-10 Red cell distribution width; LUSC cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.74 -0.3 2.1e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs3782089 0.546 rs76146604 chr11:65277512 G/T cg08676812 chr11:65308423 LTBP3 1.07 6.74 0.35 7.15e-11 Height; LUSC trans rs1814175 0.817 rs28544182 chr11:50049577 G/T cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg23172400 chr8:95962367 TP53INP1 -0.41 -8.19 -0.41 5.46e-15 Type 2 diabetes; LUSC cis rs1143633 0.615 rs4364030 chr2:113664409 C/G cg06156847 chr2:113672199 IL1F7 0.28 5.76 0.3 1.96e-8 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg00310523 chr12:86230176 RASSF9 0.51 9.82 0.47 3.65e-20 Major depressive disorder; LUSC cis rs7264396 0.690 rs2425178 chr20:34446395 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.53 -0.42 5.25e-16 Total cholesterol levels; LUSC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.78e-12 Lung disease severity in cystic fibrosis; LUSC trans rs7939886 0.920 rs61742348 chr11:55905078 C/T cg03929089 chr4:120376271 NA 0.77 6.09 0.32 3.03e-9 Myopia (pathological); LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.33 -0.41 2.17e-15 Lymphocyte counts; LUSC cis rs16949788 1.000 rs41306345 chr15:66782048 C/T cg08120210 chr15:66682733 MAP2K1 -0.6 -6.3 -0.33 9.41e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg06634786 chr22:41940651 POLR3H -0.53 -6.44 -0.33 4.05e-10 Vitiligo; LUSC cis rs7208859 0.623 rs12103440 chr17:29086657 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs12266014 0.965 rs10828722 chr10:25199951 A/G cg16316141 chr10:25305874 ENKUR;THNSL1 0.4 5.74 0.3 2.09e-8 Monocyte count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;White blood cell count;Neutrophil count;Myeloid white cell count; LUSC cis rs11758351 1.000 rs76722536 chr6:26192946 C/G cg23601095 chr6:26197514 HIST1H3D 0.72 7.37 0.37 1.35e-12 Gout;Renal underexcretion gout; LUSC cis rs6084875 0.840 rs2104143 chr20:4723157 G/A cg07258627 chr20:4721683 PRNT -0.35 -6.21 -0.32 1.57e-9 Systemic lupus erythematosus; LUSC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg12863693 chr15:85201151 NMB -0.27 -6.18 -0.32 1.89e-9 P wave terminal force; LUSC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg19346786 chr7:2764209 NA 0.41 7.12 0.36 6.5e-12 Height; LUSC cis rs950776 0.518 rs28438420 chr15:78836288 A/T cg06917634 chr15:78832804 PSMA4 -0.78 -13.66 -0.6 4.74e-34 Sudden cardiac arrest; LUSC cis rs2439831 1.000 rs2584725 chr15:43793135 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs9653442 0.527 rs11690905 chr2:100761473 C/T cg22139774 chr2:100720529 AFF3 0.41 7.09 0.36 8.12e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg15448220 chr1:150897856 SETDB1 0.4 5.82 0.3 1.36e-8 Melanoma; LUSC cis rs3820928 1.000 rs9288617 chr2:227762815 G/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.74 -0.39 1.21e-13 Pulmonary function; LUSC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg14019146 chr3:50243930 SLC38A3 -0.32 -7.09 -0.36 8.22e-12 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg05368731 chr17:41323189 NBR1 0.78 12.52 0.57 9.52e-30 Menopause (age at onset); LUSC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg00857998 chr1:205179979 DSTYK 0.64 9.83 0.47 3.41e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs72934535 0.722 rs16839813 chr2:204324094 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.59 5.84 0.3 1.25e-8 Coronary artery disease; LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg27535305 chr1:53392650 SCP2 0.38 7.08 0.36 8.63e-12 Monocyte count; LUSC cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg08999081 chr20:33150536 PIGU 0.43 7.58 0.38 3.53e-13 Coronary artery disease; LUSC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg23625390 chr15:77176239 SCAPER 0.46 6.95 0.36 1.96e-11 Blood metabolite levels; LUSC cis rs4253772 0.515 rs7287164 chr22:46781008 T/C cg00784671 chr22:46762841 CELSR1 -0.55 -6.01 -0.31 4.84e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg14582100 chr15:45693742 SPATA5L1 0.56 10.29 0.49 9.65e-22 Homoarginine levels; LUSC cis rs2730245 0.510 rs2788474 chr7:158649005 T/C cg24397884 chr7:158709396 WDR60 0.61 9.29 0.45 2.09e-18 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25789511 chr20:60757919 GTPBP5 -0.5 -6.11 -0.32 2.82e-9 Bipolar disorder and schizophrenia; LUSC trans rs72792513 1.000 rs3843863 chr2:22912149 C/T cg05844895 chr16:88969569 CBFA2T3 0.53 6.22 0.32 1.5e-9 Hepatitis B; LUSC cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.01e-43 Bladder cancer; LUSC cis rs4654899 0.932 rs10916943 chr1:21472429 T/C cg01072550 chr1:21505969 NA 0.53 8.17 0.41 6.25e-15 Superior frontal gyrus grey matter volume; LUSC cis rs4786125 0.665 rs8060329 chr16:6908864 G/A cg03623568 chr16:6915990 A2BP1 -0.5 -8.12 -0.41 8.94e-15 Heart rate variability traits (SDNN); LUSC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.59 0.38 3.18e-13 Vitiligo; LUSC cis rs3736594 0.546 rs6734059 chr2:27808154 C/T cg27432699 chr2:27873401 GPN1 -0.65 -8.89 -0.44 3.77e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7264396 0.887 rs4281980 chr20:34096581 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.39 -0.33 5.72e-10 Total cholesterol levels; LUSC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.47 -7.29 -0.37 2.27e-12 Alzheimer's disease (late onset); LUSC cis rs6545883 0.859 rs13004855 chr2:61505072 C/T cg15711740 chr2:61764176 XPO1 0.47 7.15 0.36 5.45e-12 Tuberculosis; LUSC cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg18252515 chr7:66147081 NA 1.2 13.84 0.6 9.22e-35 Diabetic kidney disease; LUSC cis rs34779708 0.931 rs2384283 chr10:35326789 G/A cg04310649 chr10:35416472 CREM -0.42 -6.35 -0.33 7.09e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9322193 1.000 rs9377229 chr6:149928791 C/T cg04369109 chr6:150039330 LATS1 -0.54 -7.86 -0.39 5.47e-14 Lung cancer; LUSC cis rs854765 0.663 rs1108648 chr17:17750558 G/A cg09796270 chr17:17721594 SREBF1 -0.45 -8.03 -0.4 1.68e-14 Total body bone mineral density; LUSC trans rs2624839 0.704 rs1046956 chr3:50222926 T/A cg21659725 chr3:3221576 CRBN -0.43 -6.44 -0.33 4.06e-10 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs6902954 chr6:135313994 C/A cg22676075 chr6:135203613 NA 0.47 7.43 0.38 9.18e-13 Red blood cell count; LUSC cis rs2274273 1.000 rs2274273 chr14:55614636 A/G cg04306507 chr14:55594613 LGALS3 -0.53 -11.39 -0.53 1.27e-25 Protein biomarker; LUSC trans rs12145833 0.596 rs1060643 chr1:243429976 G/C cg01826367 chr1:224180288 NA 0.66 5.96 0.31 6.34e-9 Obesity (early onset extreme); LUSC cis rs60733400 0.667 rs4385650 chr1:2499898 G/A cg18932078 chr1:2524107 MMEL1 0.32 6.98 0.36 1.64e-11 Multiple sclerosis; LUSC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.83 -0.39 6.45e-14 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg03146154 chr1:46216737 IPP -0.57 -8.24 -0.41 4.04e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11609545 chr12:57024192 BAZ2A -0.48 -6.36 -0.33 6.67e-10 Bipolar disorder and schizophrenia; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg22963979 chr7:1858916 MAD1L1 -0.58 -9.03 -0.44 1.39e-17 Bipolar disorder and schizophrenia; LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg02353165 chr6:42928485 GNMT 0.71 12.18 0.55 1.72e-28 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7177699 0.557 rs7403728 chr15:79112016 T/G cg15571903 chr15:79123663 NA -0.33 -6.13 -0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11644478 chr21:40555479 PSMG1 0.93 18.31 0.71 2.44e-52 Cognitive function; LUSC cis rs68170813 0.559 rs11773514 chr7:106958469 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC cis rs7089973 0.525 rs11196945 chr10:116600424 G/A cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7315438 0.517 rs11067597 chr12:115873888 C/G cg24172291 chr12:115889509 NA -0.35 -5.93 -0.31 7.38e-9 Colorectal cancer; LUSC cis rs9660992 0.512 rs12123773 chr1:205122420 C/G cg21643547 chr1:205240462 TMCC2 -0.42 -7.67 -0.39 1.93e-13 Mean corpuscular volume;Mean platelet volume; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09502511 chr6:30539237 ABCF1 0.77 6.82 0.35 4.36e-11 Cognitive performance; LUSC cis rs7577696 0.568 rs462878 chr2:32438655 A/G cg02381751 chr2:32503542 YIPF4 0.52 6.75 0.35 6.47e-11 Inflammatory biomarkers; LUSC trans rs6502050 0.835 rs9646397 chr17:80083534 G/A cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg00074818 chr8:8560427 CLDN23 -0.53 -8.55 -0.42 4.57e-16 Obesity-related traits; LUSC cis rs17030434 0.911 rs75822357 chr4:154738258 T/C cg14289246 chr4:154710475 SFRP2 -0.57 -7.49 -0.38 6.29e-13 Electrocardiographic conduction measures; LUSC cis rs67539049 1.000 rs67350204 chr8:11300293 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.39 -5.71 -0.3 2.51e-8 Itch intensity from mosquito bite; LUSC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg06238570 chr21:40685208 BRWD1 -0.56 -9.03 -0.44 1.37e-17 Menarche (age at onset); LUSC cis rs2233152 0.611 rs28660501 chr19:41300277 G/T cg21869046 chr19:41225005 ITPKC 0.45 6.46 0.33 3.6e-10 Kawasaki disease; LUSC cis rs9682041 0.627 rs6786374 chr3:170105233 A/G cg11886554 chr3:170076028 SKIL -0.68 -9.39 -0.46 9.57e-19 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs7681440 0.904 rs6816736 chr4:90765746 G/A cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg23205692 chr1:25664452 TMEM50A -0.38 -5.66 -0.3 3.27e-8 Erythrocyte sedimentation rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24545250 chr17:43025328 KIF18B -0.4 -6.0 -0.31 5.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10489202 0.513 rs4657731 chr1:168081255 C/T cg24449463 chr1:168025552 DCAF6 -0.63 -9.51 -0.46 3.96e-19 Schizophrenia; LUSC cis rs77106637 0.860 rs1552224 chr11:72433098 A/C cg03878208 chr11:72483293 STARD10 0.5 5.76 0.3 1.94e-8 Type 2 diabetes; LUSC cis rs12760731 0.720 rs12048459 chr1:178412702 T/C cg00404053 chr1:178313656 RASAL2 0.59 6.19 0.32 1.72e-9 Obesity-related traits; LUSC cis rs1443512 0.947 rs9804784 chr12:54343472 A/C cg17410650 chr12:54324560 NA -0.43 -6.97 -0.36 1.73e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7296418 0.663 rs11057276 chr12:123820397 C/T cg00376283 chr12:123451042 ABCB9 -0.71 -10.93 -0.51 5.4e-24 Platelet count; LUSC cis rs9296095 1.000 rs9296095 chr6:33542523 A/G cg14003231 chr6:33640908 ITPR3 0.43 6.91 0.35 2.51e-11 Platelet count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13310671 chr20:48553087 RNF114 0.73 6.13 0.32 2.43e-9 Cognitive performance; LUSC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs433852 0.718 rs550455 chr19:49136515 A/G cg06677660 chr19:49140777 SEC1;DBP -0.45 -5.94 -0.31 6.98e-9 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs450533 0.540 rs419764 chr4:107844157 C/T cg19546012 chr19:752860 C19orf21 -0.3 -6.11 -0.32 2.76e-9 Cancer; LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 5.87 0.31 1.06e-8 Personality dimensions; LUSC cis rs12618769 0.652 rs4851146 chr2:99237439 A/G cg10123293 chr2:99228465 UNC50 0.47 7.59 0.38 3.26e-13 Bipolar disorder; LUSC cis rs1949733 1.000 rs2631740 chr4:8484106 C/A cg11789530 chr4:8429930 ACOX3 -0.63 -9.73 -0.47 7.42e-20 Response to antineoplastic agents; LUSC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg23711669 chr6:146136114 FBXO30 0.81 15.02 0.64 2.48e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs57244997 1.000 rs73026551 chr6:162393642 A/C cg17173639 chr6:162384350 PARK2 -0.56 -5.72 -0.3 2.43e-8 Mosquito bite size; LUSC cis rs4654899 0.758 rs12402486 chr1:21447935 A/G cg01072550 chr1:21505969 NA 0.51 7.92 0.4 3.54e-14 Superior frontal gyrus grey matter volume; LUSC trans rs4332037 0.851 rs28728306 chr7:1961814 C/A cg10840412 chr1:235813424 GNG4 0.7 9.55 0.46 2.83e-19 Bipolar disorder; LUSC cis rs10489202 0.632 rs202259 chr1:167962072 G/A cg24449463 chr1:168025552 DCAF6 -0.76 -12.87 -0.58 4.47e-31 Schizophrenia; LUSC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg07741184 chr6:167504864 NA 0.34 6.3 0.33 9.61e-10 Crohn's disease; LUSC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg12454169 chr2:30669597 LCLAT1 1.02 10.57 0.5 1.01e-22 Midgestational circulating levels of PBDEs (fetal genetic effect); LUSC cis rs1577917 0.785 rs1885607 chr6:86394905 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 11.0 0.52 3.09e-24 Response to antipsychotic treatment; LUSC trans rs2679649 0.655 rs2679641 chr6:122355637 T/G cg00167820 chr8:131663355 NA 0.54 6.3 0.33 9.21e-10 Subcutaneous adipose tissue; LUSC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.79e-10 Schizophrenia; LUSC cis rs742132 0.527 rs12526321 chr6:25494503 A/G cg03517284 chr6:25882590 NA 0.46 6.34 0.33 7.3e-10 Uric acid levels; LUSC cis rs3824867 0.920 rs7108143 chr11:47453722 T/G cg20307385 chr11:47447363 PSMC3 -0.65 -9.65 -0.47 1.35e-19 Mean corpuscular hemoglobin; LUSC cis rs9796 0.870 rs2412574 chr15:41259707 G/C cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.92 -0.35 2.37e-11 Menopause (age at onset); LUSC trans rs9329221 0.710 rs11249995 chr8:10238922 T/C cg08975724 chr8:8085496 FLJ10661 0.45 6.0 0.31 5.13e-9 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15581235 chr15:41708917 RTF1 0.44 6.35 0.33 7.24e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs453301 0.571 rs330054 chr8:9088291 G/A cg21775007 chr8:11205619 TDH -0.44 -6.19 -0.32 1.76e-9 Joint mobility (Beighton score); LUSC cis rs6906287 0.647 rs13219555 chr6:118816364 G/A cg21191810 chr6:118973309 C6orf204 0.34 6.26 0.32 1.18e-9 Electrocardiographic conduction measures; LUSC cis rs9325144 0.647 rs3759139 chr12:39087609 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.45 -0.46 6.07e-19 Morning vs. evening chronotype; LUSC cis rs4953076 0.573 rs7595470 chr2:44402467 A/G cg04920474 chr2:44395004 PPM1B 0.63 8.15 0.41 7.41e-15 Height; LUSC cis rs1003719 0.715 rs2835667 chr21:38579914 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.2 -0.49 1.86e-21 Eye color traits; LUSC cis rs6701037 1.000 rs6425323 chr1:175125036 C/T cg00321850 chr1:175162397 KIAA0040 -0.4 -6.9 -0.35 2.55e-11 Alcohol dependence; LUSC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg27427491 chr17:78079615 GAA 0.31 5.95 0.31 6.88e-9 Yeast infection; LUSC cis rs6845621 0.901 rs1377146 chr4:18917384 T/C cg12196642 chr4:18937545 NA -0.34 -6.44 -0.33 4.14e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7463659 1.000 rs7836944 chr8:135436202 A/G cg17885191 chr8:135476712 NA 0.43 6.05 0.31 3.89e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6430585 0.591 rs75223002 chr2:136525309 G/T cg07169764 chr2:136633963 MCM6 1.18 17.48 0.69 4.99e-49 Corneal structure; LUSC cis rs12908161 1.000 rs35316992 chr15:85248133 A/G cg17173187 chr15:85201210 NMB 0.51 9.69 0.47 9.71e-20 Schizophrenia; LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9291683 0.551 rs62295971 chr4:9978142 G/A cg26043149 chr18:55253948 FECH 0.46 7.05 0.36 1.05e-11 Bone mineral density; LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg18404041 chr3:52824283 ITIH1 -0.6 -11.64 -0.54 1.58e-26 Bipolar disorder; LUSC cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg23750338 chr8:142222470 SLC45A4 0.48 9.38 0.46 1.02e-18 Immature fraction of reticulocytes; LUSC cis rs80130819 0.688 rs6580660 chr12:48588112 T/C cg24011408 chr12:48396354 COL2A1 0.45 5.89 0.31 9.18e-9 Prostate cancer; LUSC cis rs6545883 0.894 rs2600672 chr2:61536740 A/G cg15711740 chr2:61764176 XPO1 -0.43 -6.67 -0.34 1.09e-10 Tuberculosis; LUSC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg24675056 chr1:15929824 NA 0.46 8.02 0.4 1.83e-14 Systolic blood pressure; LUSC cis rs4363385 0.510 rs11205182 chr1:153045748 C/T cg00922841 chr1:152955080 SPRR1A -0.38 -6.5 -0.34 2.92e-10 Inflammatory skin disease; LUSC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg08917208 chr2:24149416 ATAD2B 0.53 5.87 0.31 1.03e-8 Lymphocyte counts; LUSC cis rs7914558 0.902 rs7092200 chr10:104844872 T/C cg15744005 chr10:104629667 AS3MT -0.28 -5.89 -0.31 9.39e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16553447 chr15:77197883 NA 0.46 6.29 0.33 9.76e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11167764 1.000 rs7722567 chr5:141483178 C/T cg08523384 chr5:141488047 NDFIP1 -0.5 -7.16 -0.36 5.25e-12 Crohn's disease; LUSC trans rs61931739 0.534 rs7310499 chr12:34212112 G/A cg26384229 chr12:38710491 ALG10B 0.74 12.07 0.55 4.31e-28 Morning vs. evening chronotype; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 14.73 0.63 3.3e-38 Platelet count; LUSC cis rs34779708 0.931 rs11593858 chr10:35381373 G/A cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10754283 0.967 rs10922685 chr1:90118320 A/G cg21401794 chr1:90099060 LRRC8C 0.61 8.78 0.43 8.72e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg26335602 chr6:28129616 ZNF389 -0.47 -6.36 -0.33 6.55e-10 Parkinson's disease; LUSC cis rs3768617 0.565 rs7542277 chr1:183063527 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.78 0.51 1.94e-23 Fuchs's corneal dystrophy; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg24060327 chr5:131705240 SLC22A5 -0.35 -5.91 -0.31 8.49e-9 Blood metabolite levels; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg11494091 chr17:61959527 GH2 0.63 13.38 0.59 5.59e-33 Prudent dietary pattern; LUSC cis rs7804356 1.000 rs10227231 chr7:26888074 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs6087771 0.650 rs6060395 chr20:30219823 G/C cg21427119 chr20:30132790 HM13 -0.38 -5.86 -0.31 1.14e-8 Subcortical brain region volumes;Putamen volume; LUSC cis rs2806561 0.664 rs4620508 chr1:23307438 C/T cg19743168 chr1:23544995 NA 0.39 7.19 0.37 4.23e-12 Height; LUSC cis rs7236492 0.683 rs78250476 chr18:77198934 G/A cg15644404 chr18:77186268 NFATC1 -0.68 -7.62 -0.38 2.63e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg00684032 chr4:1343700 KIAA1530 0.35 6.07 0.32 3.41e-9 Obesity-related traits; LUSC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs10465746 0.780 rs1324486 chr1:84384825 A/G cg10977910 chr1:84465055 TTLL7 -0.49 -6.95 -0.36 1.92e-11 Obesity-related traits; LUSC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg18252515 chr7:66147081 NA -1.24 -13.73 -0.6 2.53e-34 Diabetic kidney disease; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg05191729 chr10:74856975 P4HA1 0.41 6.5 0.34 2.9e-10 Mosquito bite size; LUSC cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg16339924 chr4:17578868 LAP3 0.55 8.16 0.41 7.09e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg22535103 chr8:58192502 C8orf71 -0.72 -7.55 -0.38 4.13e-13 Developmental language disorder (linguistic errors); LUSC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.94 0.44 2.77e-17 Height; LUSC cis rs2607426 1.000 rs2607422 chr19:41276990 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.63 5.71 0.3 2.48e-8 Blood protein levels; LUSC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg11062466 chr8:58055876 NA 0.52 6.76 0.35 6.25e-11 Developmental language disorder (linguistic errors); LUSC cis rs7107174 1.000 rs10899453 chr11:77997482 A/C cg02023728 chr11:77925099 USP35 0.49 7.07 0.36 9.01e-12 Testicular germ cell tumor; LUSC cis rs9303401 0.659 rs12946852 chr17:57013337 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.5 0.59 1.89e-33 Cognitive test performance; LUSC cis rs11190604 1.000 rs11190599 chr10:102295420 C/T cg07080220 chr10:102295463 HIF1AN 0.69 9.38 0.46 1.06e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg05283184 chr6:79620031 NA 0.57 11.93 0.55 1.46e-27 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg04865166 chr7:105162814 PUS7 0.51 5.84 0.3 1.25e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6693567 0.586 rs12031973 chr1:150485566 T/G cg15654264 chr1:150340011 RPRD2 0.44 6.89 0.35 2.87e-11 Migraine; LUSC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg07701084 chr6:150067640 NUP43 0.57 8.87 0.44 4.47e-17 Lung cancer; LUSC trans rs9944715 0.911 rs718513 chr18:43856267 C/G cg01718231 chr17:29326311 RNF135 -0.5 -7.08 -0.36 8.46e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs713587 0.521 rs35177510 chr2:25089594 C/A cg04586622 chr2:25135609 ADCY3 0.37 7.65 0.39 2.2e-13 Body mass index in non-asthmatics; LUSC cis rs868036 0.645 rs4776987 chr15:68123915 A/T cg05925327 chr15:68127851 NA 0.43 6.32 0.33 8.14e-10 Restless legs syndrome; LUSC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.65 -9.15 -0.45 5.77e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs2944591 0.505 rs2592127 chr2:233791648 G/T cg11972305 chr2:233791962 NGEF -0.34 -6.4 -0.33 5.18e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs12579753 0.871 rs4255611 chr12:82215969 C/A cg21231944 chr12:82153410 PPFIA2 -0.38 -5.77 -0.3 1.77e-8 Resting heart rate; LUSC cis rs11776272 0.927 rs11135789 chr8:21878607 C/T cg17168535 chr8:21777572 XPO7 -0.46 -6.7 -0.34 8.86e-11 Obesity-related traits; LUSC cis rs8114671 0.839 rs6142290 chr20:33654672 A/C cg24642439 chr20:33292090 TP53INP2 -0.41 -5.89 -0.31 9.23e-9 Height; LUSC cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg09904177 chr6:26538194 HMGN4 -0.77 -14.49 -0.62 2.83e-37 Intelligence (multi-trait analysis); LUSC cis rs12220238 0.841 rs10824161 chr10:76133762 C/G cg19889307 chr10:75911429 ADK;AP3M1 -0.51 -5.84 -0.3 1.26e-8 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs3099143 1.000 rs7174048 chr15:77165416 T/C cg21673338 chr15:77095150 SCAPER 0.81 7.7 0.39 1.56e-13 Recalcitrant atopic dermatitis; LUSC cis rs17102423 0.755 rs942627 chr14:65550025 A/G cg11161011 chr14:65562177 MAX -0.81 -12.51 -0.56 1.01e-29 Obesity-related traits; LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg23281280 chr6:28129359 ZNF389 0.49 6.24 0.32 1.34e-9 Parkinson's disease; LUSC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg17376030 chr22:41985996 PMM1 -0.48 -6.02 -0.31 4.57e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg05623727 chr3:50126028 RBM5 0.32 5.93 0.31 7.61e-9 Intelligence (multi-trait analysis); LUSC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.67 -0.3 3.03e-8 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27158523 chr6:149867355 PPIL4 -0.43 -6.29 -0.33 1.02e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7772486 0.875 rs56181683 chr6:146286620 A/G cg13319975 chr6:146136371 FBXO30 0.47 6.83 0.35 4.05e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs950169 0.840 rs2896002 chr15:84945121 A/G cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs6570726 0.967 rs365515 chr6:145802833 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -6.57 -0.34 1.88e-10 Lobe attachment (rater-scored or self-reported); LUSC trans rs9393777 0.720 rs35769282 chr6:26999908 G/C cg06606381 chr12:133084897 FBRSL1 -0.61 -6.44 -0.33 4.28e-10 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg23093090 chr10:104574429 C10orf26 0.45 8.53 0.42 5.03e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2635047 1.000 rs2635043 chr18:44679769 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.93 0.35 2.16e-11 Educational attainment; LUSC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg18512352 chr11:47633146 NA -0.48 -9.87 -0.48 2.52e-20 Subjective well-being; LUSC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg02423579 chr7:2872169 GNA12 -0.45 -6.89 -0.35 2.85e-11 Height; LUSC cis rs3087591 0.708 rs9894648 chr17:29653293 T/C cg24425628 chr17:29625626 OMG;NF1 0.49 7.3 0.37 2.17e-12 Hip circumference; LUSC cis rs10078 0.571 rs2721028 chr5:443849 A/G cg08916839 chr5:415575 AHRR 0.83 7.78 0.39 8.85e-14 Fat distribution (HIV); LUSC cis rs11122272 0.668 rs2749712 chr1:231537751 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.24 -0.49 1.4e-21 Hemoglobin concentration; LUSC cis rs61990749 0.544 rs3759728 chr14:78230159 A/T cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.57 0.34 1.94e-10 Fibroblast growth factor basic levels; LUSC trans rs6502050 0.764 rs7215277 chr17:80159283 C/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.81e-10 Life satisfaction; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg05025164 chr4:1340916 KIAA1530 0.42 6.59 0.34 1.74e-10 Obesity-related traits; LUSC cis rs9640161 0.830 rs3757423 chr7:150067714 A/G cg10018233 chr7:150070692 REPIN1 -0.46 -9.42 -0.46 7.73e-19 Blood protein levels;Circulating chemerin levels; LUSC cis rs4812048 0.895 rs236691 chr20:57583536 G/C cg14073986 chr20:57617431 SLMO2 0.58 6.17 0.32 1.99e-9 Mean platelet volume; LUSC cis rs7168353 0.519 rs11074140 chr15:93635244 C/G cg12595281 chr15:93633172 RGMA -0.31 -5.77 -0.3 1.81e-8 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg09365446 chr1:150670422 GOLPH3L 0.47 6.94 0.36 2.04e-11 Melanoma; LUSC cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg05768032 chr16:30646687 NA 0.38 5.75 0.3 2.02e-8 Multiple myeloma; LUSC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg12311346 chr5:56204834 C5orf35 -1.01 -14.56 -0.62 1.62e-37 Initial pursuit acceleration; LUSC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg09021430 chr5:549028 NA -0.55 -7.27 -0.37 2.64e-12 Obesity-related traits; LUSC cis rs7705502 1.000 rs17763772 chr5:173380934 A/G cg18693985 chr5:173351052 CPEB4 -0.4 -6.17 -0.32 2.01e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs12410462 0.579 rs116423559 chr1:227575014 A/G cg04117972 chr1:227635322 NA 0.6 6.37 0.33 6.36e-10 Major depressive disorder; LUSC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg18825119 chr6:163149453 PACRG;PARK2 0.6 8.45 0.42 9.09e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12893668 0.697 rs67899457 chr14:104060066 A/T cg04998671 chr14:104000505 TRMT61A -0.43 -6.28 -0.33 1.04e-9 Reticulocyte count; LUSC cis rs4423214 1.000 rs4944946 chr11:71159429 G/A cg05163923 chr11:71159392 DHCR7 0.74 10.95 0.51 4.74e-24 Vitamin D levels; LUSC cis rs4629180 0.675 rs908132 chr2:102093096 A/G cg01388757 chr2:102091195 RFX8 -0.36 -6.13 -0.32 2.43e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg08975724 chr8:8085496 FLJ10661 0.66 9.97 0.48 1.15e-20 Neuroticism; LUSC cis rs6977660 0.714 rs10252597 chr7:19791171 G/T cg07541023 chr7:19748670 TWISTNB -0.68 -7.26 -0.37 2.73e-12 Thyroid stimulating hormone; LUSC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs11098499 0.954 rs7654587 chr4:120388406 C/T cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.52e-25 Corneal astigmatism; LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.21 -0.32 1.61e-9 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.88 0.35 2.89e-11 Menarche (age at onset); LUSC cis rs2112347 0.502 rs34342 chr5:74934213 A/C cg19683494 chr5:74908142 NA -0.53 -6.79 -0.35 5.09e-11 Body mass index (joint analysis main effects and smoking interaction);Waist circumference;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Hip circumference;Body mass index;Body mass index in physically active individuals;Obesity; LUSC cis rs6541297 0.775 rs4846910 chr1:230291441 C/A cg05784532 chr1:230284198 GALNT2 0.64 8.84 0.44 5.65e-17 Coronary artery disease; LUSC cis rs3862260 0.967 rs3862261 chr1:120160822 G/A cg16322792 chr1:120165303 ZNF697 0.5 9.59 0.46 2.2e-19 Systemic lupus erythematosus; LUSC cis rs12950390 0.853 rs28589850 chr17:45855713 A/G cg03474202 chr17:45855739 NA -0.29 -6.74 -0.35 7.09e-11 IgG glycosylation; LUSC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg12311346 chr5:56204834 C5orf35 -0.83 -13.46 -0.59 2.82e-33 Initial pursuit acceleration; LUSC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg04166393 chr7:2884313 GNA12 0.42 5.72 0.3 2.43e-8 Height; LUSC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.61 0.34 1.5e-10 Tonsillectomy; LUSC cis rs2046867 0.628 rs7617996 chr3:72915315 C/T cg25664220 chr3:72788482 NA -0.54 -9.77 -0.47 5.54e-20 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg06784218 chr1:46089804 CCDC17 -0.48 -9.21 -0.45 3.67e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3771570 1.000 rs62193208 chr2:242322430 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.92 0.35 2.29e-11 Prostate cancer; LUSC cis rs7523273 0.526 rs2724394 chr1:208017072 T/A cg22525895 chr1:207977042 MIR29B2 -0.41 -6.83 -0.35 3.95e-11 Schizophrenia; LUSC cis rs6964587 0.692 rs4729018 chr7:91644613 C/T cg17063962 chr7:91808500 NA 0.58 9.54 0.46 3.05e-19 Breast cancer; LUSC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg19418458 chr7:158789849 NA -0.65 -11.06 -0.52 1.93e-24 Facial morphology (factor 20); LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg23131131 chr22:24373011 LOC391322 -0.51 -7.43 -0.38 9.43e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs72634258 0.554 rs12061787 chr1:7888730 G/C cg26816564 chr1:7831052 VAMP3 0.94 13.42 0.59 4e-33 Inflammatory bowel disease; LUSC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg19468946 chr17:37922297 IKZF3 0.47 7.75 0.39 1.08e-13 Self-reported allergy; LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg23758822 chr17:41437982 NA 1.05 19.65 0.73 1.16e-57 Menopause (age at onset); LUSC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg17376030 chr22:41985996 PMM1 -0.46 -5.77 -0.3 1.85e-8 Vitiligo; LUSC cis rs40363 1.000 rs37769 chr16:3514580 C/G cg01073479 chr16:3509474 NAT15 0.39 5.65 0.3 3.46e-8 Tuberculosis; LUSC cis rs554111 0.634 rs4654875 chr1:21165176 A/G cg01072550 chr1:21505969 NA 0.39 5.92 0.31 8.17e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs3125734 0.671 rs3852406 chr10:64015162 T/C cg19640130 chr10:64028056 RTKN2 -0.4 -7.02 -0.36 1.23e-11 Rheumatoid arthritis; LUSC cis rs7267979 0.932 rs424487 chr20:25468131 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.44 0.75 8.46e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13067593 1.000 rs66966540 chr3:188573196 A/C cg17809494 chr3:188572244 LPP 0.42 5.73 0.3 2.22e-8 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg25036284 chr2:26402008 FAM59B 0.72 10.2 0.49 1.88e-21 Gut microbiome composition (summer); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg10164686 chr6:2971950 SERPINB6 0.39 6.18 0.32 1.88e-9 Schizophrenia; LUSC trans rs877282 0.947 rs7923867 chr10:768094 G/A cg22713356 chr15:30763199 NA 1.1 15.68 0.65 6.69e-42 Uric acid levels; LUSC cis rs5758659 0.652 rs5751195 chr22:42380001 A/C cg04733989 chr22:42467013 NAGA 0.37 6.14 0.32 2.33e-9 Cognitive function; LUSC cis rs34375054 0.573 rs12581813 chr12:125656402 A/G cg25124228 chr12:125621409 AACS -0.5 -6.36 -0.33 6.59e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs905938 0.559 rs76306191 chr1:155006451 C/G cg16256492 chr1:154989843 ZBTB7B 0.63 7.23 0.37 3.24e-12 Waist-to-hip ratio adjusted for body mass index;Birth length;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg02038168 chr22:39784481 NA -0.48 -7.79 -0.39 8.53e-14 Intelligence (multi-trait analysis); LUSC cis rs7589342 0.895 rs11901644 chr2:106432113 T/G cg14210321 chr2:106509881 NCK2 -0.55 -8.12 -0.41 8.83e-15 Addiction; LUSC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg01579765 chr21:45077557 HSF2BP -0.58 -12.69 -0.57 2.29e-30 Mean corpuscular volume; LUSC cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg12011299 chr4:100065546 ADH4 0.7 10.49 0.5 1.92e-22 Alcohol dependence; LUSC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.94 -0.44 2.75e-17 Breast cancer; LUSC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg03929089 chr4:120376271 NA -1.04 -20.32 -0.74 2.46e-60 Height; LUSC cis rs6987853 0.686 rs10087350 chr8:42359484 G/A cg09913449 chr8:42400586 C8orf40 -0.44 -7.45 -0.38 8.03e-13 Mean corpuscular hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24980700 chr20:30410739 MYLK2 0.41 6.12 0.32 2.67e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11031096 0.782 rs4910888 chr11:4152915 G/A cg18678763 chr11:4115507 RRM1 -0.52 -7.56 -0.38 4.06e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4594175 0.926 rs12432356 chr14:51631223 T/G cg23942311 chr14:51606299 NA 0.3 5.68 0.3 2.86e-8 Cancer; LUSC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg14196790 chr5:131705035 SLC22A5 0.48 7.96 0.4 2.65e-14 Blood metabolite levels; LUSC cis rs713587 0.967 rs6752378 chr2:25150116 C/A cg15423357 chr2:25149977 NA 0.47 9.67 0.47 1.17e-19 Body mass index in non-asthmatics; LUSC cis rs2948294 0.588 rs7011221 chr8:8114246 C/T cg08975724 chr8:8085496 FLJ10661 0.55 7.17 0.37 4.9e-12 Red cell distribution width; LUSC cis rs7914558 0.646 rs12768205 chr10:104647849 C/T cg05855489 chr10:104503620 C10orf26 0.43 5.82 0.3 1.42e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs12210905 1.000 rs3800310 chr6:27206843 C/G cg11837749 chr1:55047332 ACOT11 0.58 6.19 0.32 1.76e-9 Hip circumference adjusted for BMI; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg12419862 chr22:24373484 LOC391322 -0.89 -14.8 -0.63 1.88e-38 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9649213 1.000 rs9649213 chr7:98021211 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.6 -8.95 -0.44 2.45e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs7809950 0.817 rs17154091 chr7:107084790 T/C cg23024343 chr7:107201750 COG5 -0.7 -10.34 -0.49 6.27e-22 Coronary artery disease; LUSC cis rs2439831 0.850 rs7169322 chr15:44131014 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.98 0.44 2e-17 Lung cancer in ever smokers; LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg07507251 chr3:52567010 NT5DC2 0.36 6.91 0.35 2.39e-11 Bipolar disorder; LUSC cis rs1448094 0.967 rs10746357 chr12:86341044 A/T cg18827107 chr12:86230957 RASSF9 -0.4 -5.87 -0.31 1.04e-8 Major depressive disorder; LUSC cis rs2692947 0.644 rs1030864 chr2:96822373 A/G cg22654517 chr2:96458247 NA 0.32 5.87 0.31 1.06e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9486719 0.948 rs12203657 chr6:96883285 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs7786808 0.712 rs2335170 chr7:158207101 G/A cg09998033 chr7:158218633 PTPRN2 -0.51 -8.2 -0.41 5.11e-15 Obesity-related traits; LUSC trans rs9354352 0.791 rs4710306 chr6:66700271 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.57 -8.05 -0.4 1.48e-14 Initial pursuit acceleration in psychotic disorders; LUSC cis rs2710642 0.861 rs2710644 chr2:63248968 A/C cg17519650 chr2:63277830 OTX1 0.57 7.89 0.4 4.46e-14 LDL cholesterol levels;LDL cholesterol; LUSC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.85 0.39 5.6e-14 Parkinson's disease; LUSC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg25019033 chr10:957182 NA -0.52 -7.22 -0.37 3.55e-12 Eosinophil percentage of granulocytes; LUSC cis rs9646944 0.501 rs3771158 chr2:103009894 A/G cg20060108 chr2:102954350 IL1RL1 0.49 6.91 0.35 2.5e-11 Blood protein levels; LUSC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs79387448 0.701 rs76943877 chr2:102970677 T/C cg09003973 chr2:102972529 NA 1.21 12.75 0.57 1.31e-30 Gut microbiota (bacterial taxa); LUSC cis rs7949030 0.653 rs2516634 chr11:62367186 G/A cg13298116 chr11:62369859 EML3;MTA2 -0.58 -9.69 -0.47 9.99e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.76 0.39 1.04e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.83 0.51 1.23e-23 Menopause (age at onset); LUSC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC trans rs35110281 0.811 rs1122873 chr21:45044672 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.82 0.54 3.63e-27 Mean corpuscular volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10445487 chr16:75599896 GABARAPL2 0.44 6.84 0.35 3.78e-11 Triglycerides; LUSC trans rs12210905 0.925 rs114172511 chr6:26964301 G/A cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs7264396 0.943 rs11167267 chr20:34109273 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.22 -0.32 1.48e-9 Total cholesterol levels; LUSC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg19901468 chr14:105411992 AHNAK2 -0.71 -12.36 -0.56 3.84e-29 Rheumatoid arthritis; LUSC cis rs2806561 0.765 rs2776815 chr1:23510584 C/T cg19743168 chr1:23544995 NA -0.38 -7.56 -0.38 3.93e-13 Height; LUSC cis rs77633900 0.614 rs2468123 chr15:76931345 T/C cg21673338 chr15:77095150 SCAPER -0.76 -7.65 -0.39 2.13e-13 Non-glioblastoma glioma;Glioma; LUSC trans rs9393777 0.920 rs13207689 chr6:27369704 C/G cg01620082 chr3:125678407 NA -0.8 -7.02 -0.36 1.28e-11 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17051395 chr17:78644292 RPTOR 0.44 6.41 0.33 5e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9399401 0.667 rs6900233 chr6:142717283 C/G cg03128060 chr6:142623767 GPR126 0.58 9.64 0.47 1.45e-19 Chronic obstructive pulmonary disease; LUSC cis rs921968 0.608 rs658378 chr2:219483881 T/A cg02176678 chr2:219576539 TTLL4 0.59 10.5 0.5 1.72e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg12219531 chr12:120966889 COQ5 0.59 8.11 0.41 1e-14 High light scatter reticulocyte count; LUSC trans rs6952808 1.000 rs4601204 chr7:1890925 C/T cg24247370 chr13:99142703 STK24 -0.33 -6.01 -0.31 4.74e-9 Bipolar disorder and schizophrenia; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg14264380 chr17:79651103 ARL16;HGS 0.44 5.95 0.31 6.64e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg13736514 chr6:26305472 NA -0.45 -8.95 -0.44 2.55e-17 Educational attainment; LUSC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC cis rs9902453 1.000 rs4465649 chr17:28394747 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.73 -0.43 1.28e-16 Coffee consumption (cups per day); LUSC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg00409905 chr10:38381863 ZNF37A -0.35 -5.98 -0.31 5.62e-9 Extrinsic epigenetic age acceleration; LUSC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg12257692 chr3:49977190 RBM6 0.24 6.57 0.34 1.93e-10 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.599 rs12309369 chr12:38419683 C/G cg13010199 chr12:38710504 ALG10B -0.44 -6.55 -0.34 2.12e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7829975 0.714 rs4840362 chr8:8670082 C/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.81 -0.43 6.9e-17 Mood instability; LUSC cis rs11190604 1.000 rs2295779 chr10:102296061 A/G cg07080220 chr10:102295463 HIF1AN 0.67 9.15 0.45 5.81e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9287719 0.967 rs6706542 chr2:10742491 A/C cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs9926296 0.624 rs1110331 chr16:89774396 A/G cg26513180 chr16:89883248 FANCA -0.49 -7.71 -0.39 1.49e-13 Vitiligo; LUSC cis rs9517320 0.534 rs3858776 chr13:99161457 C/T cg20487152 chr13:99095054 FARP1 -0.35 -6.19 -0.32 1.73e-9 Longevity; LUSC cis rs72781680 0.752 rs72780185 chr2:24003967 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs477692 1.000 rs558764 chr10:131426957 G/T cg11019008 chr10:131425282 MGMT -0.39 -5.84 -0.3 1.21e-8 Response to temozolomide; LUSC cis rs9443645 0.527 rs4706746 chr6:79674176 G/A cg23262351 chr6:79576851 IRAK1BP1 -0.39 -5.99 -0.31 5.52e-9 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.568 rs1047158 chr12:123644056 C/A cg05973401 chr12:123451056 ABCB9 0.54 6.64 0.34 1.24e-10 Neutrophil percentage of white cells; LUSC cis rs6940638 0.513 rs4424065 chr6:27036456 C/T cg05738196 chr6:26577821 NA -0.52 -8.06 -0.4 1.41e-14 Intelligence (multi-trait analysis); LUSC cis rs7312933 0.592 rs1551210 chr12:42865874 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 6.54 0.34 2.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.27 0.59 1.45e-32 Chronic sinus infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24442661 chr7:36192818 EEPD1 -0.41 -6.11 -0.32 2.73e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8063761 0.640 rs4785760 chr16:90051438 G/A cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.77 12.08 0.55 3.87e-28 Squamous cell carcinoma; LUSC cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg02466173 chr16:30829666 NA -0.59 -11.02 -0.52 2.66e-24 Multiple myeloma; LUSC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg06637938 chr14:75390232 RPS6KL1 0.51 8.18 0.41 6.13e-15 Height; LUSC cis rs17193922 0.798 rs7203644 chr16:53547209 C/T cg09728985 chr16:53543985 NA -0.39 -6.37 -0.33 6.31e-10 Hip circumference adjusted for BMI; LUSC trans rs208520 0.909 rs60604603 chr6:67022955 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 8.76 0.43 9.74e-17 Exhaled nitric oxide output; LUSC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg00509249 chr6:109615579 CCDC162 -0.32 -5.81 -0.3 1.49e-8 Reticulocyte fraction of red cells; LUSC cis rs634534 0.622 rs1308733 chr11:65720841 T/C cg02427764 chr11:65769310 BANF1;EIF1AD -0.47 -6.82 -0.35 4.35e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9815354 0.812 rs73071304 chr3:41797504 G/C cg03022575 chr3:42003672 ULK4 0.85 8.73 0.43 1.26e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs977987 0.843 rs4888372 chr16:75313485 G/A cg03315344 chr16:75512273 CHST6 0.46 8.64 0.43 2.38e-16 Dupuytren's disease; LUSC cis rs2734839 0.964 rs2734833 chr11:113292920 G/A cg14159747 chr11:113255604 NA 0.23 5.71 0.3 2.55e-8 Information processing speed; LUSC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg18827107 chr12:86230957 RASSF9 -0.43 -6.48 -0.33 3.22e-10 Major depressive disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05454237 chr11:14913849 CYP2R1 -0.47 -6.07 -0.32 3.48e-9 Hepatitis; LUSC cis rs4481887 0.617 rs28719164 chr1:248543802 T/G cg26353448 chr1:248524236 OR2T4 -0.33 -6.2 -0.32 1.64e-9 Common traits (Other); LUSC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs4722585 0.605 rs10268883 chr7:26200417 C/T cg07876897 chr7:26191696 NFE2L3 0.48 7.24 0.37 3.21e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs10927875 0.864 rs12744578 chr1:16173110 A/T cg22431228 chr1:16359049 CLCNKA 0.41 7.48 0.38 6.66e-13 Dilated cardiomyopathy; LUSC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg05132306 chr1:1846340 CALML6 -0.34 -8.55 -0.42 4.61e-16 Body mass index; LUSC cis rs4466137 0.868 rs4703962 chr5:82999808 A/G cg15083037 chr5:83017644 HAPLN1 -0.6 -7.71 -0.39 1.5e-13 Prostate cancer; LUSC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg04398451 chr17:18023971 MYO15A -0.48 -7.35 -0.37 1.57e-12 Total body bone mineral density; LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg25767906 chr1:53392781 SCP2 0.71 14.14 0.61 6.86e-36 Monocyte count; LUSC cis rs2348418 0.966 rs4144964 chr12:28684182 C/T cg13890972 chr12:28721907 NA -0.34 -5.76 -0.3 1.93e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs983392 1.000 rs4939311 chr11:59877967 C/T cg24026212 chr11:59952134 MS4A6A -0.33 -5.79 -0.3 1.64e-8 Alzheimer's disease (late onset); LUSC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg15448220 chr1:150897856 SETDB1 0.39 5.87 0.31 1.04e-8 Melanoma; LUSC cis rs868036 0.918 rs4238411 chr15:68079424 A/T cg08079166 chr15:68083412 MAP2K5 0.4 8.16 0.41 7.05e-15 Restless legs syndrome; LUSC cis rs1953600 0.837 rs3098105 chr10:81953266 C/T cg00277334 chr10:82204260 NA 0.45 7.08 0.36 8.35e-12 Sarcoidosis; LUSC cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg25208724 chr1:156163844 SLC25A44 0.98 21.78 0.77 4.56e-66 Testicular germ cell tumor; LUSC trans rs79976124 0.876 rs17511913 chr6:66644361 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 8.73 0.43 1.23e-16 Type 2 diabetes; LUSC cis rs7759001 0.857 rs980963 chr6:27360937 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.77e-8 Glomerular filtration rate (creatinine); LUSC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg05110241 chr16:68378359 PRMT7 -0.56 -6.38 -0.33 5.96e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg05340658 chr4:99064831 C4orf37 0.64 10.17 0.49 2.45e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4664308 0.935 rs6731260 chr2:160977769 A/G cg03641300 chr2:160917029 PLA2R1 -0.68 -11.63 -0.54 1.73e-26 Idiopathic membranous nephropathy; LUSC cis rs3820928 0.874 rs12105952 chr2:227864521 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.65 -0.39 2.18e-13 Pulmonary function; LUSC cis rs7828089 0.935 rs896375 chr8:22262098 A/G cg12081754 chr8:22256438 SLC39A14 0.53 8.28 0.41 2.96e-15 Verbal declarative memory; LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg20887711 chr4:1340912 KIAA1530 0.69 10.75 0.51 2.38e-23 Longevity; LUSC trans rs6011368 0.654 rs1570521 chr20:62911019 G/T cg13869341 chr1:15865 WASH5P 0.39 6.08 0.32 3.28e-9 Clozapine-induced cytotoxicity; LUSC cis rs72781680 0.898 rs10490752 chr2:24025132 C/T cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs9937943 0.667 rs11862508 chr16:74598688 T/C cg01733217 chr16:74700730 RFWD3 0.61 6.93 0.35 2.13e-11 Neutrophil percentage of white cells; LUSC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg20203395 chr5:56204925 C5orf35 -0.53 -7.67 -0.39 1.85e-13 Coronary artery disease; LUSC trans rs12439619 0.846 rs62010071 chr15:82581783 G/C cg04831495 chr15:85060580 GOLGA6L5 -0.48 -6.37 -0.33 6.15e-10 Intelligence (multi-trait analysis); LUSC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg07636037 chr3:49044803 WDR6 0.44 6.38 0.33 5.9e-10 Resting heart rate; LUSC trans rs9747201 0.925 rs11867806 chr17:80072049 A/G cg07393940 chr7:158741817 NA -0.55 -8.51 -0.42 5.85e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9902453 0.900 rs9910970 chr17:28478329 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.85 0.44 5.37e-17 Coffee consumption (cups per day); LUSC trans rs12310956 0.510 rs1386936 chr12:33875369 G/A cg13010199 chr12:38710504 ALG10B 0.45 6.9 0.35 2.67e-11 Morning vs. evening chronotype; LUSC cis rs7828089 0.582 rs13282084 chr8:22266280 T/C cg12081754 chr8:22256438 SLC39A14 0.79 12.61 0.57 4.49e-30 Verbal declarative memory; LUSC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.88 -0.35 3.01e-11 Intelligence (multi-trait analysis); LUSC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg11764359 chr7:65958608 NA 0.68 10.85 0.51 1.06e-23 Aortic root size; LUSC cis rs7577696 0.962 rs6738349 chr2:32314131 G/C cg02381751 chr2:32503542 YIPF4 -0.4 -5.78 -0.3 1.72e-8 Inflammatory biomarkers; LUSC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.01e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1371867 0.846 rs1660338 chr8:101242757 C/G cg06636551 chr8:101224915 SPAG1 -0.39 -7.23 -0.37 3.35e-12 Atrioventricular conduction; LUSC cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg09626299 chr10:82213104 TSPAN14 -0.2 -6.01 -0.31 4.78e-9 Post bronchodilator FEV1; LUSC cis rs28785552 0.800 rs1971063 chr19:53232854 G/C cg10871876 chr19:53194124 ZNF83 0.55 8.17 0.41 6.31e-15 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg15556689 chr8:8085844 FLJ10661 0.63 9.92 0.48 1.68e-20 Mood instability; LUSC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg26314531 chr2:26401878 FAM59B -0.68 -9.29 -0.45 2.1e-18 Gut microbiome composition (summer); LUSC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -8.08 -0.4 1.17e-14 Neuroticism; LUSC cis rs8032315 0.965 rs7497304 chr15:91429176 G/T cg04510874 chr15:91427884 FES 0.32 6.33 0.33 8.06e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2839186 0.867 rs13050387 chr21:47701423 C/T cg05896524 chr21:47604654 C21orf56 0.4 5.91 0.31 8.52e-9 Testicular germ cell tumor; LUSC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg13939156 chr17:80058883 NA 0.33 6.44 0.33 4.21e-10 Life satisfaction; LUSC cis rs1784581 0.588 rs4131681 chr6:162422167 T/G cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.06e-20 Itch intensity from mosquito bite; LUSC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.29 -5.69 -0.3 2.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs6750795 0.542 rs1797388 chr2:232415981 T/G cg19187155 chr2:232395269 NMUR1 0.8 13.65 0.6 5.01e-34 Height; LUSC cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg27446573 chr6:127587934 RNF146 0.8 12.78 0.57 1.04e-30 Breast cancer; LUSC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg23281280 chr6:28129359 ZNF389 0.45 5.67 0.3 3.04e-8 Depression; LUSC cis rs9811920 0.965 rs9837131 chr3:99854514 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.33 -5.75 -0.3 2.03e-8 Axial length; LUSC cis rs1577917 0.876 rs1582126 chr6:86697205 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.7 -0.43 1.49e-16 Response to antipsychotic treatment; LUSC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg10729496 chr3:10149963 C3orf24 0.52 6.98 0.36 1.56e-11 Alzheimer's disease; LUSC cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg16325326 chr1:53192061 ZYG11B -0.89 -16.56 -0.67 2.25e-45 Monocyte count; LUSC cis rs9304742 0.962 rs12461796 chr19:53455088 T/A cg09915433 chr19:53449742 NA -0.61 -9.67 -0.47 1.14e-19 Psoriasis; LUSC cis rs72960926 0.744 rs6914400 chr6:75018941 G/A cg03266952 chr6:74778945 NA -0.8 -6.98 -0.36 1.58e-11 Metabolite levels (MHPG); LUSC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg20503657 chr10:835505 NA 0.87 12.23 0.56 1.12e-28 Eosinophil percentage of granulocytes; LUSC cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.61 0.5 7.62e-23 Bladder cancer; LUSC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg11764359 chr7:65958608 NA 0.49 6.1 0.32 2.93e-9 Aortic root size; LUSC cis rs11971779 0.680 rs7804388 chr7:139086413 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg00074818 chr8:8560427 CLDN23 0.56 9.55 0.46 2.94e-19 Obesity-related traits; LUSC cis rs12681288 0.644 rs2123058 chr8:1000304 A/G cg04851639 chr8:1020857 NA -0.37 -7.66 -0.39 1.99e-13 Schizophrenia; LUSC cis rs1113500 0.933 rs12035689 chr1:108636756 T/C cg06207961 chr1:108661230 NA 0.41 7.57 0.38 3.61e-13 Growth-regulated protein alpha levels; LUSC cis rs10791323 0.602 rs7946895 chr11:133733893 T/C cg15485101 chr11:133734466 NA 0.41 7.73 0.39 1.28e-13 Childhood ear infection; LUSC cis rs9325144 0.600 rs61931871 chr12:38829889 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.44 -0.46 6.82e-19 Morning vs. evening chronotype; LUSC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs7216064 0.532 rs8065296 chr17:66018562 T/A cg12091567 chr17:66097778 LOC651250 0.88 14.09 0.61 9.98e-36 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg09650180 chr20:62225654 GMEB2 -0.66 -9.66 -0.47 1.22e-19 Glioblastoma; LUSC cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.05 20.0 0.74 4.44e-59 Cognitive ability; LUSC cis rs6952809 0.532 rs2057840 chr7:2432797 C/G cg23289794 chr7:2394357 EIF3B -0.71 -9.81 -0.47 3.9e-20 Multiple sclerosis; LUSC cis rs13315871 0.929 rs4560319 chr3:58386274 C/T cg12435725 chr3:58293450 RPP14 -0.73 -7.35 -0.37 1.56e-12 Cholesterol, total; LUSC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg02569458 chr12:86230093 RASSF9 0.55 9.43 0.46 7.16e-19 Major depressive disorder; LUSC cis rs459571 0.959 rs408307 chr9:136892523 A/G cg14462750 chr9:136913113 BRD3 -0.41 -6.22 -0.32 1.46e-9 Platelet distribution width; LUSC cis rs12618769 0.597 rs72819987 chr2:99046253 A/G cg10123293 chr2:99228465 UNC50 0.47 7.77 0.39 9.91e-14 Bipolar disorder; LUSC cis rs79387448 0.745 rs72993720 chr2:103121269 A/T cg09003973 chr2:102972529 NA 0.87 8.56 0.42 4.28e-16 Gut microbiota (bacterial taxa); LUSC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg09365446 chr1:150670422 GOLPH3L -0.4 -5.84 -0.3 1.21e-8 Tonsillectomy; LUSC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg09580153 chr6:41068724 NFYA;LOC221442 0.45 6.74 0.35 7.05e-11 Alzheimer's disease (late onset); LUSC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg18827107 chr12:86230957 RASSF9 -0.49 -7.16 -0.36 5.22e-12 Major depressive disorder; LUSC cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg02527881 chr3:46936655 PTH1R 0.66 11.99 0.55 8.87e-28 Birth weight; LUSC cis rs9914988 0.559 rs1109024 chr17:27189971 C/T cg09479241 chr17:27052676 TLCD1 -0.43 -5.79 -0.3 1.65e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7208859 0.673 rs9913782 chr17:29237384 A/G cg13385521 chr17:29058706 SUZ12P 0.59 5.7 0.3 2.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11650494 0.710 rs73987293 chr17:47474728 A/G cg08112188 chr17:47440006 ZNF652 0.93 7.93 0.4 3.3e-14 Prostate cancer; LUSC cis rs877282 0.898 rs2004478 chr10:770709 C/A cg17470449 chr10:769945 NA 0.51 7.25 0.37 3.01e-12 Uric acid levels; LUSC trans rs1728785 1.000 rs1749791 chr16:68572347 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs9660992 0.710 rs1668864 chr1:205248799 T/C cg00857998 chr1:205179979 DSTYK 0.61 9.17 0.45 4.95e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2777491 0.915 rs8036498 chr15:41603276 A/G cg18705301 chr15:41695430 NDUFAF1 -0.76 -13.71 -0.6 3e-34 Ulcerative colitis; LUSC trans rs61931739 0.635 rs1852225 chr12:33963004 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.62 0.38 2.61e-13 Morning vs. evening chronotype; LUSC cis rs7296418 0.663 rs28450974 chr12:123861420 G/A cg05973401 chr12:123451056 ABCB9 0.55 7.9 0.4 4.02e-14 Platelet count; LUSC cis rs3096299 0.802 rs3102336 chr16:89442006 C/T cg16743903 chr16:89593216 SPG7 -0.4 -5.97 -0.31 6.19e-9 Multiple myeloma (IgH translocation); LUSC cis rs11190604 1.000 rs2298075 chr10:102247408 C/A cg07080220 chr10:102295463 HIF1AN 0.63 8.42 0.42 1.14e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg03146154 chr1:46216737 IPP 0.56 8.32 0.41 2.35e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8017423 0.845 rs8005870 chr14:90723172 A/C cg14092571 chr14:90743983 NA -0.36 -5.84 -0.3 1.24e-8 Mortality in heart failure; LUSC cis rs4474465 1.000 rs7943815 chr11:78173160 A/G cg27205649 chr11:78285834 NARS2 -0.48 -5.72 -0.3 2.42e-8 Alzheimer's disease (survival time); LUSC trans rs7980799 0.565 rs2200159 chr12:33648544 G/C cg26384229 chr12:38710491 ALG10B -0.53 -7.92 -0.4 3.67e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs887829 0.569 rs4663967 chr2:234653184 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.7 -0.39 1.5700000000000001e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg04414720 chr1:150670196 GOLPH3L -0.38 -5.81 -0.3 1.43e-8 Tonsillectomy; LUSC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 9.28 0.45 2.22e-18 Menopause (age at onset); LUSC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg22508957 chr16:3507546 NAT15 -0.91 -10.51 -0.5 1.7e-22 Tuberculosis; LUSC cis rs2073300 0.609 rs2281434 chr20:23378101 C/A cg12062639 chr20:23401060 NAPB 0.94 8.24 0.41 3.94e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg12016809 chr21:47604291 C21orf56 -0.45 -6.71 -0.34 8.23e-11 Testicular germ cell tumor; LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7264396 1.000 rs224415 chr20:34135629 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -6.66 -0.34 1.1e-10 Total cholesterol levels; LUSC cis rs10865397 0.506 rs60764301 chr2:73384850 G/A cg24220031 chr2:73402428 NA -0.26 -6.05 -0.31 3.89e-9 Intelligence (multi-trait analysis); LUSC cis rs954108 0.522 rs7983818 chr13:29383182 A/C cg11788234 chr13:29393811 NA -0.51 -10.18 -0.49 2.17e-21 Obesity-related traits; LUSC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg11871910 chr12:69753446 YEATS4 0.91 16.98 0.68 4.65e-47 Cerebrospinal fluid biomarker levels; LUSC cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg16339924 chr4:17578868 LAP3 -0.5 -7.3 -0.37 2.15e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9462846 0.691 rs9462853 chr6:42910666 T/C cg21280719 chr6:42927975 GNMT -0.26 -5.71 -0.3 2.49e-8 Blood protein levels; LUSC cis rs889312 0.924 rs1910020 chr5:56026500 T/C cg18230493 chr5:56204884 C5orf35 -0.41 -5.9 -0.31 8.69e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -10.9 -0.51 6.92e-24 Chronic sinus infection; LUSC cis rs2303282 0.716 rs2617849 chr16:56404703 C/T cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs7824557 0.583 rs2263511 chr8:11233318 A/C cg27411982 chr8:10470053 RP1L1 -0.37 -5.75 -0.3 2e-8 Retinal vascular caliber; LUSC cis rs240764 0.658 rs9322213 chr6:101248480 T/C cg09795085 chr6:101329169 ASCC3 -0.46 -6.63 -0.34 1.33e-10 Neuroticism; LUSC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.16 0.49 2.71e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6087990 0.806 rs4911108 chr20:31375311 A/G cg13636640 chr20:31349939 DNMT3B 0.89 17.85 0.7 1.67e-50 Ulcerative colitis; LUSC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg14893161 chr1:205819251 PM20D1 0.44 6.07 0.32 3.44e-9 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs72960926 0.744 rs11752920 chr6:75000195 C/T cg03266952 chr6:74778945 NA -0.76 -6.65 -0.34 1.21e-10 Metabolite levels (MHPG); LUSC cis rs11190604 1.000 rs3793771 chr10:102222957 C/G cg07080220 chr10:102295463 HIF1AN 0.64 8.67 0.43 1.95e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6961069 0.777 rs6961024 chr7:80249671 G/T cg04458919 chr7:80252533 CD36 0.37 6.58 0.34 1.78e-10 Platelet count; LUSC cis rs7681440 0.904 rs7671549 chr4:90771147 T/A cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.18e-8 Dementia with Lewy bodies; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg06873352 chr17:61820015 STRADA 0.7 12.64 0.57 3.53e-30 Prudent dietary pattern; LUSC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg07424592 chr7:64974309 NA -0.64 -5.71 -0.3 2.46e-8 Diabetic kidney disease; LUSC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg21573476 chr21:45109991 RRP1B -0.37 -6.05 -0.31 3.92e-9 Mean corpuscular volume; LUSC cis rs9650657 0.771 rs6601513 chr8:10594843 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.11 -0.32 2.71e-9 Neuroticism; LUSC cis rs16854884 0.657 rs16854819 chr3:143736126 C/T cg06585982 chr3:143692056 C3orf58 -0.49 -7.81 -0.39 7.48e-14 Economic and political preferences (feminism/equality); LUSC cis rs12682352 0.602 rs1473029 chr8:8668917 A/C cg15556689 chr8:8085844 FLJ10661 0.58 8.68 0.43 1.73e-16 Neuroticism; LUSC cis rs8060686 0.641 rs28548264 chr16:68211321 A/G cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs9549260 0.816 rs9532582 chr13:41251207 A/G cg21288729 chr13:41239152 FOXO1 0.57 8.6 0.43 3.04e-16 Red blood cell count; LUSC cis rs6545883 0.894 rs12620105 chr2:61512321 A/T cg15711740 chr2:61764176 XPO1 0.46 6.93 0.35 2.16e-11 Tuberculosis; LUSC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg21856205 chr7:94953877 PON1 -0.35 -5.71 -0.3 2.51e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg15242686 chr22:24348715 GSTTP1 0.55 9.14 0.45 6.06e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg18099408 chr3:52552593 STAB1 -0.43 -7.35 -0.37 1.53e-12 Bipolar disorder; LUSC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs6582630 0.555 rs7301250 chr12:38596244 G/T cg13010199 chr12:38710504 ALG10B 0.64 9.79 0.47 4.45e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs796364 0.806 rs203767 chr2:200902411 G/A cg23649088 chr2:200775458 C2orf69 -0.57 -7.01 -0.36 1.33e-11 Schizophrenia; LUSC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6496044 0.548 rs7163032 chr15:86072419 T/A cg13263323 chr15:86062960 AKAP13 -0.37 -6.16 -0.32 2.06e-9 Interstitial lung disease; LUSC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.63 9.69 0.47 9.58e-20 Cognitive test performance; LUSC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg19077165 chr18:44547161 KATNAL2 0.44 6.67 0.34 1.04e-10 Personality dimensions; LUSC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg26566898 chr11:117069891 TAGLN -0.48 -8.46 -0.42 8.42e-16 Blood protein levels; LUSC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg27165867 chr14:105738592 BRF1 -0.54 -7.77 -0.39 9.99e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs78572108 0.858 rs13384309 chr2:42265288 G/A cg00607755 chr2:42274082 PKDCC 0.36 6.52 0.34 2.61e-10 Total body bone mineral density; LUSC trans rs7746199 0.736 rs34105070 chr6:27560805 C/T cg06606381 chr12:133084897 FBRSL1 -0.97 -8.98 -0.44 1.96e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs877282 0.838 rs11253408 chr10:796374 T/C cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs7592578 0.713 rs60915953 chr2:191331304 G/C cg10560079 chr2:191398806 TMEM194B -0.67 -7.59 -0.38 3.33e-13 Diastolic blood pressure; LUSC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.05 0.4 1.44e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7208859 0.623 rs59029591 chr17:29235746 A/C cg13385521 chr17:29058706 SUZ12P 0.59 5.7 0.3 2.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.48 0.53 5.99e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4561483 0.771 rs12924398 chr16:11972948 T/A cg08843971 chr16:11963173 GSPT1 -0.44 -6.12 -0.32 2.62e-9 Testicular germ cell tumor; LUSC cis rs1256061 0.630 rs1256030 chr14:64747170 A/G cg21174375 chr14:64681225 SYNE2 0.35 6.46 0.33 3.77e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -7.41 -0.38 1.03e-12 Developmental language disorder (linguistic errors); LUSC cis rs1403694 0.515 rs822362 chr3:186453065 A/C cg12454167 chr3:186435060 KNG1 0.29 7.6 0.38 3.1e-13 Blood protein levels; LUSC cis rs11690935 0.531 rs4280428 chr2:172813219 G/A cg13550731 chr2:172543902 DYNC1I2 0.49 7.27 0.37 2.52e-12 Schizophrenia; LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg27170947 chr2:26402098 FAM59B -0.69 -10.59 -0.5 8.47e-23 Gut microbiome composition (summer); LUSC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg11247378 chr22:39784982 NA -0.63 -11.01 -0.52 2.83e-24 Post bronchodilator FEV1; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04688917 chr3:179040469 ZNF639 0.4 6.18 0.32 1.88e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg04871131 chr7:94954202 PON1 -0.35 -5.65 -0.3 3.52e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1178968 1.000 rs7793764 chr7:72759953 G/T cg25889504 chr7:72793014 NA 0.52 6.81 0.35 4.42e-11 Triglyceride levels; LUSC cis rs870825 0.587 rs7682995 chr4:185640684 G/A cg04058563 chr4:185651563 MLF1IP 0.86 13.38 0.59 5.34e-33 Blood protein levels; LUSC cis rs12413816 0.784 rs11258560 chr10:13770137 A/G cg16485048 chr10:13749193 FRMD4A 0.44 7.35 0.37 1.55e-12 Red cell distribution width; LUSC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg14668632 chr7:2872130 GNA12 -0.48 -7.19 -0.37 4.21e-12 Height; LUSC cis rs62458065 0.513 rs10268803 chr7:32547835 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.92 -0.31 7.77e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs66731853 0.769 rs657624 chr1:20888348 C/T cg04087271 chr1:20915334 CDA -0.51 -8.86 -0.44 4.73e-17 Mean corpuscular volume; LUSC cis rs4499344 0.730 rs453804 chr19:33105612 T/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.87 13.17 0.58 3.36e-32 Mean platelet volume; LUSC cis rs9527 1.000 rs9527 chr10:104623578 C/T cg05855489 chr10:104503620 C10orf26 0.59 8.14 0.41 7.93e-15 Arsenic metabolism; LUSC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg00484396 chr16:3507460 NAT15 -0.43 -7.01 -0.36 1.29e-11 Body mass index (adult); LUSC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg09323728 chr8:95962352 TP53INP1 -0.39 -7.78 -0.39 9.11e-14 Type 2 diabetes; LUSC cis rs7089973 0.872 rs7923295 chr10:116625159 C/G cg23260525 chr10:116636907 FAM160B1 -0.42 -8.61 -0.43 2.9e-16 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11601602 0.531 rs35031414 chr11:28545563 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.51 5.99 0.31 5.4e-9 Obesity-related traits; LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg08088566 chr11:430123 ANO9 0.62 7.21 0.37 3.77e-12 Body mass index; LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg05368731 chr17:41323189 NBR1 0.92 15.61 0.65 1.22e-41 Menopause (age at onset); LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg07167872 chr1:205819463 PM20D1 0.76 13.51 0.59 1.81e-33 Menarche (age at onset); LUSC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg12826209 chr6:26865740 GUSBL1 0.74 8.95 0.44 2.43e-17 Intelligence (multi-trait analysis); LUSC cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg09904177 chr6:26538194 HMGN4 -0.51 -8.05 -0.4 1.45e-14 Schizophrenia; LUSC trans rs6076960 0.598 rs3905168 chr20:6226752 C/T cg17788362 chr6:86352627 SYNCRIP 0.42 6.11 0.32 2.8e-9 Smooth-surface caries; LUSC trans rs853679 1.000 rs853685 chr6:28288785 C/T cg01620082 chr3:125678407 NA -0.57 -6.43 -0.33 4.42e-10 Depression; LUSC cis rs427941 0.632 rs201470 chr7:101744045 G/A cg06246474 chr7:101738831 CUX1 0.39 6.42 0.33 4.68e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs2692947 0.770 rs6719831 chr2:96502590 A/C cg22654517 chr2:96458247 NA 0.38 7.48 0.38 6.83e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs668210 0.793 rs677350 chr11:65761967 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.59 7.78 0.39 9.13e-14 Cerebrospinal fluid biomarker levels; LUSC trans rs4332037 1.000 rs6947019 chr7:1950337 G/A cg10840412 chr1:235813424 GNG4 0.67 8.99 0.44 1.9e-17 Bipolar disorder; LUSC cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg27129171 chr3:47204927 SETD2 0.7 11.75 0.54 6.42e-27 Colorectal cancer; LUSC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.45 -6.37 -0.33 6.32e-10 Osteoporosis; LUSC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -6.93 -0.35 2.13e-11 Electroencephalogram traits; LUSC trans rs8002861 0.870 rs1348671 chr13:44449505 C/T cg12856521 chr11:46389249 DGKZ 0.42 6.75 0.35 6.53e-11 Leprosy; LUSC cis rs11039100 0.920 rs11039075 chr11:5820917 C/A cg05234568 chr11:5960015 NA -0.51 -5.76 -0.3 1.87e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2806561 0.514 rs7519093 chr1:23541078 A/T cg19743168 chr1:23544995 NA -0.53 -10.64 -0.5 5.92e-23 Height; LUSC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg24296786 chr1:45957014 TESK2 0.47 6.91 0.35 2.51e-11 High light scatter reticulocyte count; LUSC cis rs870825 0.698 rs7673203 chr4:185625397 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.82 0.35 4.3e-11 Parkinson's disease; LUSC cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg04414720 chr1:150670196 GOLPH3L -0.44 -7.05 -0.36 1.05e-11 Tonsillectomy; LUSC cis rs4363385 0.667 rs2066004 chr1:152922896 A/G cg00922841 chr1:152955080 SPRR1A -0.42 -7.03 -0.36 1.2e-11 Inflammatory skin disease; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs7586879 0.521 rs7597332 chr2:25075675 A/G cg04586622 chr2:25135609 ADCY3 0.39 8.05 0.4 1.43e-14 Body mass index; LUSC cis rs907612 0.638 rs11041476 chr11:1875067 C/T cg07277017 chr11:1874093 LSP1 0.33 5.83 0.3 1.31e-8 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg01528321 chr10:82214614 TSPAN14 0.62 9.17 0.45 5.01e-18 Post bronchodilator FEV1; LUSC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 12.65 0.57 3.2e-30 Total body bone mineral density; LUSC cis rs34638657 0.732 rs62045962 chr16:82200604 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.33 -0.33 7.89e-10 Lung adenocarcinoma; LUSC cis rs1044826 1.000 rs9860201 chr3:139091444 G/C cg00490450 chr3:139108681 COPB2 0.55 7.37 0.37 1.34e-12 Obesity-related traits; LUSC trans rs6951245 1.000 rs2363286 chr7:1091625 A/G cg13565492 chr6:43139072 SRF -0.56 -6.0 -0.31 5.03e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6692729 0.897 rs7518926 chr1:227000011 C/G cg10327440 chr1:227177885 CDC42BPA 0.47 6.72 0.35 7.93e-11 Electrodermal activity; LUSC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4588572 0.643 rs10063742 chr5:77759362 A/G cg11547950 chr5:77652471 NA -0.56 -7.9 -0.4 4.03e-14 Triglycerides; LUSC cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg23788917 chr6:8435910 SLC35B3 -0.5 -7.42 -0.38 9.8e-13 Motion sickness; LUSC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg18402987 chr7:1209562 NA 0.47 6.13 0.32 2.54e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4308124 0.708 rs6747657 chr2:112003163 C/T cg04571233 chr2:111982156 NA -0.48 -6.37 -0.33 6.14e-10 Vitiligo; LUSC cis rs9311676 0.656 rs62258140 chr3:58407083 C/T cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.3e-10 Systemic lupus erythematosus; LUSC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg06046430 chr4:77819534 ANKRD56 0.49 7.16 0.36 5.01e-12 Emphysema distribution in smoking; LUSC cis rs7572644 0.766 rs10495761 chr2:28235955 T/C cg27432699 chr2:27873401 GPN1 0.52 6.44 0.33 4.19e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.32 0.74 2.41e-60 Cognitive ability; LUSC cis rs10489202 0.634 rs11582396 chr1:168077636 C/T cg24449463 chr1:168025552 DCAF6 -0.64 -9.52 -0.46 3.62e-19 Schizophrenia; LUSC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg02569458 chr12:86230093 RASSF9 0.58 9.82 0.47 3.54e-20 Major depressive disorder; LUSC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg13385521 chr17:29058706 SUZ12P 0.65 6.32 0.33 8.37e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11650494 0.908 rs75092916 chr17:47412578 T/C cg08112188 chr17:47440006 ZNF652 1.22 10.07 0.48 5.39e-21 Prostate cancer; LUSC cis rs6121246 0.567 rs2889488 chr20:30185758 G/A cg18721089 chr20:30220636 NA -0.41 -6.57 -0.34 1.93e-10 Mean corpuscular hemoglobin; LUSC cis rs6426558 0.515 rs7412928 chr1:227332148 C/T cg10327440 chr1:227177885 CDC42BPA -0.53 -7.25 -0.37 2.98e-12 Neutrophil percentage of white cells; LUSC cis rs2153904 1.000 rs2153904 chr1:205642790 A/C cg23034840 chr1:205782522 SLC41A1 0.56 6.38 0.33 5.87e-10 Prostate-specific antigen levels; LUSC cis rs3008870 1.000 rs12740884 chr1:67459855 C/A cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg20476274 chr7:133979776 SLC35B4 0.87 17.01 0.68 3.4e-47 Mean platelet volume; LUSC cis rs59698941 0.709 rs58237345 chr5:132266351 T/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.36 -0.33 6.75e-10 Apolipoprotein A-IV levels; LUSC trans rs10221833 1.000 rs441414 chr2:165675693 A/G cg10323433 chr13:47471562 HTR2A 0.62 6.54 0.34 2.32e-10 Response to statin therapy; LUSC cis rs4356932 0.967 rs13113632 chr4:76972516 C/T cg00809888 chr4:76862425 NAAA 0.35 5.86 0.31 1.14e-8 Blood protein levels; LUSC cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.91 0.31 8.42e-9 Rheumatoid arthritis; LUSC cis rs12618769 0.597 rs56197140 chr2:99113740 T/C cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs9469578 1.000 rs73743326 chr6:33709980 C/A cg18708504 chr6:33715942 IP6K3 0.72 9.23 0.45 3.08e-18 Phosphorus levels; LUSC cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg19920283 chr7:105172520 RINT1 0.63 7.0 0.36 1.42e-11 Bipolar disorder (body mass index interaction); LUSC cis rs7264396 0.836 rs6120995 chr20:34185726 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -7.65 -0.39 2.17e-13 Total cholesterol levels; LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg10729496 chr3:10149963 C3orf24 0.49 6.14 0.32 2.34e-9 Alzheimer's disease; LUSC cis rs1007190 0.570 rs7224712 chr17:42874218 G/T cg15406952 chr17:42872593 NA -0.59 -6.13 -0.32 2.45e-9 DNA methylation (variation); LUSC trans rs4332037 0.851 rs10268609 chr7:1962163 A/C cg10840412 chr1:235813424 GNG4 0.63 8.71 0.43 1.4e-16 Bipolar disorder; LUSC cis rs7570971 0.583 rs1375132 chr2:135954405 A/G cg07169764 chr2:136633963 MCM6 0.51 6.73 0.35 7.42e-11 Blood metabolite levels;Body mass index;Cholesterol, total; LUSC cis rs6815814 0.950 rs5743560 chr4:38806200 G/T cg02016764 chr4:38805732 TLR1 -0.53 -5.74 -0.3 2.16e-8 Breast cancer; LUSC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11890956 chr21:40555474 PSMG1 0.97 17.61 0.69 1.44e-49 Cognitive function; LUSC cis rs11051970 0.679 rs2651377 chr12:32556919 A/C cg02745156 chr12:32552066 NA 0.37 6.81 0.35 4.42e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2479724 0.870 rs7766960 chr6:41918190 T/G cg17623882 chr6:41773611 USP49 -0.58 -9.45 -0.46 5.97e-19 Menarche (age at onset); LUSC cis rs9303542 0.559 rs12602539 chr17:46617459 T/A cg09704116 chr17:46666958 LOC404266 -0.38 -6.69 -0.34 9.51e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs8077889 0.750 rs231533 chr17:41945588 A/G cg26893861 chr17:41843967 DUSP3 -0.88 -11.11 -0.52 1.31e-24 Triglycerides; LUSC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03264133 chr6:25882463 NA 0.38 6.32 0.33 8.5e-10 Intelligence (multi-trait analysis); LUSC cis rs909002 0.800 rs3753612 chr1:32082410 C/G cg01639898 chr1:32083012 HCRTR1 0.3 7.42 0.38 1.01e-12 Intelligence (multi-trait analysis); LUSC cis rs568617 1.000 rs641018 chr11:65655393 G/C cg19792802 chr11:65647270 CTSW 0.4 6.24 0.32 1.35e-9 Crohn's disease; LUSC cis rs7223966 1.000 rs8075422 chr17:61804686 G/A cg00945038 chr17:61921165 SMARCD2 0.4 6.1 0.32 2.88e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs478304 0.718 rs1144789 chr11:65389631 A/G cg05805236 chr11:65401703 PCNXL3 0.48 7.88 0.4 4.69e-14 Acne (severe); LUSC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.62 13.2 0.59 2.56e-32 Monocyte percentage of white cells; LUSC cis rs10504073 0.647 rs10435574 chr8:49996028 G/A cg00325661 chr8:49890786 NA 0.62 9.91 0.48 1.8899999999999998e-20 Blood metabolite ratios; LUSC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.56e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.8 10.54 0.5 1.34e-22 Schizophrenia; LUSC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.49 0.5 1.86e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2274273 0.870 rs67514154 chr14:55767382 T/C cg04306507 chr14:55594613 LGALS3 0.54 11.92 0.55 1.5e-27 Protein biomarker; LUSC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg27494647 chr7:150038898 RARRES2 0.48 7.41 0.38 1.06e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg11965913 chr1:205819406 PM20D1 0.5 7.16 0.36 5.26e-12 Parkinson's disease; LUSC cis rs4400599 1.000 rs3001363 chr1:154125067 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 0.36 5.86 0.31 1.09e-8 Platelet distribution width; LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg13395646 chr4:1353034 KIAA1530 -0.57 -8.6 -0.43 3.06e-16 Longevity; LUSC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg08680598 chr22:49984980 NA -0.34 -6.54 -0.34 2.31e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9649213 0.614 rs4236537 chr7:97996593 T/C cg08684580 chr7:98029266 BAIAP2L1 0.38 5.65 0.3 3.38e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs911186 0.730 rs2393911 chr6:27057079 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.46 -8.0 -0.4 2.13e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs175714 0.845 rs175706 chr14:75976200 G/A cg01624173 chr14:75981868 NA 0.45 9.46 0.46 5.61e-19 Lymphocyte counts; LUSC cis rs6496667 0.510 rs16944405 chr15:90975517 A/G cg22089800 chr15:90895588 ZNF774 0.55 8.02 0.4 1.79e-14 Rheumatoid arthritis; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg27094323 chr7:1216898 NA -0.44 -7.44 -0.38 8.32e-13 Longevity;Endometriosis; LUSC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11644478 chr21:40555479 PSMG1 -0.75 -13.36 -0.59 6.48e-33 Cognitive function; LUSC cis rs4974559 0.501 rs900013 chr4:1240450 G/A cg02980000 chr4:1222292 CTBP1 -1.04 -10.42 -0.5 3.44e-22 Systolic blood pressure; LUSC cis rs3008870 1.000 rs12117131 chr1:67451922 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.11 -0.64 1.09e-39 Lymphocyte percentage of white cells; LUSC cis rs259282 0.605 rs8101007 chr19:33109557 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.65 9.58 0.46 2.27e-19 Schizophrenia; LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg02951883 chr7:2050386 MAD1L1 -0.59 -11.17 -0.52 8.06e-25 Bipolar disorder and schizophrenia; LUSC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs61990749 0.597 rs59848135 chr14:78129000 G/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.58 -6.17 -0.32 1.97e-9 Fibroblast growth factor basic levels; LUSC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg03806693 chr22:41940476 POLR3H 0.99 13.49 0.59 2e-33 Vitiligo; LUSC cis rs34638657 0.872 rs2967355 chr16:82200103 G/T cg09439754 chr16:82129088 HSD17B2 0.39 6.07 0.32 3.4e-9 Lung adenocarcinoma; LUSC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg21918786 chr6:109611834 NA -0.42 -7.34 -0.37 1.6e-12 Reticulocyte fraction of red cells; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg02475777 chr4:1388615 CRIPAK 0.45 6.76 0.35 6.33e-11 Obesity-related traits; LUSC cis rs7760535 0.656 rs1883136 chr6:111907023 G/T cg22127309 chr6:111907043 TRAF3IP2 -0.44 -8.77 -0.43 9.43e-17 Metabolic traits; LUSC cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg23711669 chr6:146136114 FBXO30 -0.85 -15.57 -0.65 1.75e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs11190604 1.000 rs2495752 chr10:102326115 T/C cg07080220 chr10:102295463 HIF1AN 0.7 8.86 0.44 4.77e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs921968 0.541 rs585185 chr2:219457741 G/A cg02176678 chr2:219576539 TTLL4 0.75 14.7 0.63 4.6e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs11098499 0.954 rs71614438 chr4:120371252 G/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg11344533 chr11:111475393 SIK2 -0.49 -6.6 -0.34 1.59e-10 Primary sclerosing cholangitis; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg06873352 chr17:61820015 STRADA 0.72 12.78 0.57 1.04e-30 Prudent dietary pattern; LUSC cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg26384229 chr12:38710491 ALG10B 0.63 9.83 0.47 3.32e-20 Morning vs. evening chronotype; LUSC cis rs61869271 0.797 rs6585313 chr10:116745558 T/A cg23260525 chr10:116636907 FAM160B1 0.3 5.79 0.3 1.61e-8 Tonsillectomy; LUSC cis rs6964587 1.000 rs6944591 chr7:91642714 T/C cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.6e-8 Breast cancer; LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.08 16.84 0.68 1.64e-46 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg07677032 chr17:61819896 STRADA 0.53 8.99 0.44 1.89e-17 Prudent dietary pattern; LUSC cis rs12410462 0.892 rs75757169 chr1:227629855 A/G cg23173402 chr1:227635558 NA 0.6 7.19 0.37 4.24e-12 Major depressive disorder; LUSC cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg18681998 chr4:17616180 MED28 -0.81 -14.11 -0.61 8.73e-36 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs62244186 0.714 rs2293600 chr3:44599103 G/T cg02073558 chr3:44770973 ZNF501 -0.46 -7.27 -0.37 2.54e-12 Depressive symptoms; LUSC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg13607699 chr17:42295918 UBTF 0.5 7.75 0.39 1.09e-13 Total body bone mineral density; LUSC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg21573476 chr21:45109991 RRP1B 0.4 6.67 0.34 1.09e-10 Mean corpuscular volume; LUSC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg09849774 chr21:43526787 UMODL1;C21orf128 -0.54 -8.18 -0.41 5.91e-15 IgG glycosylation; LUSC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg27432699 chr2:27873401 GPN1 -0.58 -8.46 -0.42 8.46e-16 Total body bone mineral density; LUSC cis rs7520050 0.751 rs592214 chr1:46024505 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.4 -6.42 -0.33 4.73e-10 Red blood cell count;Reticulocyte count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25291941 chr8:99129319 POP1;HRSP12 -0.5 -6.49 -0.33 3.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg09359103 chr1:154839909 KCNN3 -0.7 -16.23 -0.66 4.49e-44 Prostate cancer; LUSC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg05754148 chr16:3507555 NAT15 0.43 5.68 0.3 2.94e-8 Body mass index (adult); LUSC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg14784868 chr12:69753453 YEATS4 0.9 16.36 0.67 1.37e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs35883536 0.626 rs80052576 chr1:101039229 A/G cg06223162 chr1:101003688 GPR88 -0.47 -8.99 -0.44 1.89e-17 Monocyte count; LUSC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg17366294 chr4:99064904 C4orf37 0.55 9.03 0.44 1.42e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs4889855 0.614 rs9892081 chr17:78484484 A/C cg16591659 chr17:78472290 NA 0.45 7.58 0.38 3.53e-13 Fractional excretion of uric acid; LUSC trans rs6445975 0.666 rs6767291 chr3:58408910 C/T cg18950693 chr14:70346909 SMOC1 -0.4 -6.06 -0.31 3.75e-9 Systemic lupus erythematosus; LUSC cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC cis rs9473147 0.843 rs7772202 chr6:47621579 G/A cg12968598 chr6:47444699 CD2AP 0.39 5.88 0.31 9.81e-9 Platelet distribution width;Mean platelet volume; LUSC trans rs9291683 0.546 rs4575994 chr4:9997979 G/A cg26043149 chr18:55253948 FECH 0.48 7.32 0.37 1.85e-12 Bone mineral density; LUSC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg26408565 chr15:76604113 ETFA -0.52 -8.47 -0.42 7.93e-16 Blood metabolite levels; LUSC cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg20203395 chr5:56204925 C5orf35 0.57 8.17 0.41 6.39e-15 Initial pursuit acceleration; LUSC cis rs7106204 0.514 rs7126508 chr11:24255147 G/A ch.11.24196551F chr11:24239977 NA 0.92 10.2 0.49 1.98e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs17253792 0.822 rs76201070 chr14:56063604 A/C cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs6087990 0.735 rs1855350 chr20:31387525 C/T cg13636640 chr20:31349939 DNMT3B 0.93 18.92 0.72 8.99e-55 Ulcerative colitis; LUSC cis rs1957429 0.901 rs8009996 chr14:65351582 A/G cg23373153 chr14:65346875 NA 1.05 12.67 0.57 2.53e-30 Pediatric areal bone mineral density (radius); LUSC cis rs6076065 0.707 rs12349 chr20:23352480 A/G cg11657817 chr20:23433608 CST11 0.54 11.13 0.52 1.05e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs11030122 0.645 rs11493482 chr11:4034772 A/G cg18678763 chr11:4115507 RRM1 -0.47 -6.12 -0.32 2.58e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg24060327 chr5:131705240 SLC22A5 0.66 11.0 0.52 3.24e-24 Breast cancer; LUSC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg11632617 chr15:75315747 PPCDC -0.51 -6.68 -0.34 9.77e-11 Blood trace element (Zn levels); LUSC cis rs3862435 0.764 rs79900358 chr15:90993295 A/G cg22089800 chr15:90895588 ZNF774 0.57 5.97 0.31 5.95e-9 Response to exercise (triglyceride level interaction); LUSC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg12463550 chr7:65579703 CRCP -0.42 -6.12 -0.32 2.63e-9 Aortic root size; LUSC cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg00277334 chr10:82204260 NA -0.95 -20.77 -0.75 4.31e-62 Post bronchodilator FEV1; LUSC trans rs1478897 0.575 rs12679960 chr8:11430990 C/T cg08975724 chr8:8085496 FLJ10661 0.48 6.81 0.35 4.48e-11 Systemic lupus erythematosus; LUSC cis rs11690935 0.632 rs12052246 chr2:172895606 G/T cg13550731 chr2:172543902 DYNC1I2 0.56 9.03 0.44 1.42e-17 Schizophrenia; LUSC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg23158103 chr7:148848205 ZNF398 -0.45 -7.31 -0.37 1.97e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg26314531 chr2:26401878 FAM59B -0.66 -9.25 -0.45 2.84e-18 Gut microbiome composition (summer); LUSC cis rs7223966 1.000 rs61360320 chr17:61800392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.92 0.35 2.31e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg04775059 chr7:64541387 NA 0.47 6.83 0.35 4.05e-11 Calcium levels; LUSC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg03128945 chr5:622914 CEP72 0.34 5.83 0.3 1.29e-8 Obesity-related traits; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.2 0.32 1.68e-9 Platelet count; LUSC cis rs11650494 0.808 rs76366926 chr17:47396628 T/C cg08112188 chr17:47440006 ZNF652 1.25 10.63 0.5 6.24e-23 Prostate cancer; LUSC trans rs6952808 0.717 rs10950422 chr7:1926577 T/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.42 0.33 4.75e-10 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.37e-9 Life satisfaction; LUSC cis rs35883536 0.588 rs955338 chr1:101108794 G/C cg06223162 chr1:101003688 GPR88 0.35 6.3 0.33 9.2e-10 Monocyte count; LUSC cis rs61931739 0.534 rs10844729 chr12:34022919 A/G cg06521331 chr12:34319734 NA -0.43 -7.13 -0.36 6.1e-12 Morning vs. evening chronotype; LUSC cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg08213375 chr14:104286397 PPP1R13B -0.53 -10.12 -0.48 3.59e-21 Schizophrenia; LUSC cis rs1044826 0.667 rs295471 chr3:139213922 G/C cg15131784 chr3:139108705 COPB2 0.39 6.36 0.33 6.82e-10 Obesity-related traits; LUSC cis rs72829446 0.530 rs9646411 chr17:7398909 A/G cg02795151 chr17:7402630 POLR2A -0.58 -7.04 -0.36 1.08e-11 Androgen levels; LUSC cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.31 -5.81 -0.3 1.47e-8 IgG glycosylation; LUSC cis rs2204008 0.837 rs12370891 chr12:37984531 A/G cg26384229 chr12:38710491 ALG10B 0.93 15.94 0.66 5.93e-43 Bladder cancer; LUSC cis rs16866061 0.515 rs1027340 chr2:225370554 C/A cg12698349 chr2:225449008 CUL3 0.98 19.49 0.73 4.9e-57 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs354225 0.553 rs7564719 chr2:54829731 A/C cg26097391 chr2:54893211 SPTBN1 0.43 6.54 0.34 2.35e-10 Schizophrenia; LUSC cis rs12950390 0.893 rs4239165 chr17:45847272 A/T cg03474202 chr17:45855739 NA -0.29 -6.52 -0.34 2.58e-10 IgG glycosylation; LUSC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg17143192 chr8:8559678 CLDN23 0.59 8.43 0.42 1.07e-15 Obesity-related traits; LUSC cis rs317689 0.658 rs490872 chr12:69645864 A/G cg11871910 chr12:69753446 YEATS4 0.44 5.82 0.3 1.37e-8 Response to diuretic therapy; LUSC cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg23788917 chr6:8435910 SLC35B3 0.49 7.33 0.37 1.78e-12 Motion sickness; LUSC cis rs7945705 0.791 rs10769958 chr11:8815115 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -9.68 -0.47 1.09e-19 Hemoglobin concentration; LUSC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs2273669 0.588 rs111773102 chr6:109306480 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.21 -0.32 1.62e-9 Prostate cancer; LUSC cis rs72781680 0.752 rs72796114 chr2:23906133 C/G cg20701182 chr2:24300061 SF3B14 0.73 7.06 0.36 9.63e-12 Lymphocyte counts; LUSC cis rs3806843 1.000 rs6885319 chr5:140200611 A/C cg26395211 chr5:140044315 WDR55 -0.37 -5.7 -0.3 2.69e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs1908814 0.516 rs35391955 chr8:11796728 A/C cg06636001 chr8:8085503 FLJ10661 0.55 8.04 0.4 1.6e-14 Neuroticism; LUSC cis rs4253772 0.678 rs1053332 chr22:46640179 A/G cg09491104 chr22:46646882 C22orf40 -0.61 -8.56 -0.42 4.16e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg06481639 chr22:41940642 POLR3H 0.48 5.72 0.3 2.37e-8 Vitiligo; LUSC cis rs11252926 0.931 rs12355162 chr10:563472 G/A cg16346588 chr10:242978 ZMYND11 -0.44 -5.88 -0.31 9.73e-9 Psychosis in Alzheimer's disease; LUSC cis rs1801251 0.778 rs2592115 chr2:233736349 C/T cg08000102 chr2:233561755 GIGYF2 -0.49 -7.67 -0.39 1.92e-13 Coronary artery disease; LUSC cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg23262073 chr20:60523788 NA -0.39 -5.77 -0.3 1.79e-8 Body mass index; LUSC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg02187348 chr16:89574699 SPG7 0.51 6.91 0.35 2.39e-11 Multiple myeloma (IgH translocation); LUSC cis rs861020 0.677 rs12723578 chr1:210032392 G/A cg09163369 chr1:210001066 C1orf107 -0.56 -6.19 -0.32 1.8e-9 Orofacial clefts; LUSC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg06618935 chr21:46677482 NA -0.4 -7.68 -0.39 1.74e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11630290 0.592 rs11071769 chr15:64156842 G/C cg12036633 chr15:63758958 NA 0.53 6.74 0.35 7.13e-11 Iris characteristics; LUSC cis rs2486288 0.656 rs8039138 chr15:45551592 C/T cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.67 -0.5 4.42e-23 Glomerular filtration rate; LUSC cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg03517284 chr6:25882590 NA -0.52 -9.66 -0.47 1.21e-19 Blood metabolite levels; LUSC cis rs11105298 0.786 rs10858867 chr12:89851166 C/T cg00757033 chr12:89920650 WDR51B 0.6 10.33 0.49 7.01e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs77972916 0.505 rs3851318 chr2:43532808 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.46 -5.91 -0.31 8.43e-9 Granulocyte percentage of myeloid white cells; LUSC trans rs7819412 0.775 rs34094119 chr8:10935898 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.75 -0.35 6.58e-11 Triglycerides; LUSC trans rs9929218 0.551 rs4783663 chr16:68720271 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.08 23.28 0.79 6.73e-72 Colorectal cancer; LUSC trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg11887960 chr12:57824829 NA 0.58 7.05 0.36 1.05e-11 Lung disease severity in cystic fibrosis; LUSC cis rs909002 0.800 rs4949454 chr1:32099041 A/G cg01639898 chr1:32083012 HCRTR1 -0.31 -7.61 -0.38 2.74e-13 Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.51 0.34 2.77e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1998174 0.509 rs6657315 chr1:171827283 G/T cg13482142 chr2:234261155 NA 0.42 6.09 0.32 3.11e-9 Platelet distribution width; LUSC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg02187348 chr16:89574699 SPG7 0.51 7.12 0.36 6.76e-12 Multiple myeloma (IgH translocation); LUSC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg01879757 chr17:41196368 BRCA1 0.5 8.11 0.41 9.96e-15 Menopause (age at onset); LUSC cis rs16949788 0.793 rs78483581 chr15:66769365 C/T cg08120210 chr15:66682733 MAP2K1 -0.63 -6.52 -0.34 2.56e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg06784218 chr1:46089804 CCDC17 -0.57 -11.23 -0.52 4.96e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg10792982 chr14:105748885 BRF1 0.49 9.0 0.44 1.75e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs11098499 0.697 rs10020027 chr4:120381879 G/C cg24375607 chr4:120327624 NA 0.77 11.46 0.53 7.47e-26 Corneal astigmatism; LUSC trans rs75763843 0.941 rs12456054 chr18:42077425 A/G cg12620806 chr12:5602045 NTF3 0.51 6.07 0.32 3.39e-9 Mean platelet volume; LUSC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC trans rs1268789 0.545 rs753752 chr4:79372930 C/T cg06112894 chr8:141469983 TRAPPC9 0.23 6.2 0.32 1.71e-9 Hair shape;Hair morphology; LUSC cis rs4332037 0.539 rs57148375 chr7:2025001 G/C cg23422044 chr7:1970798 MAD1L1 -0.55 -6.07 -0.32 3.53e-9 Bipolar disorder; LUSC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg00484396 chr16:3507460 NAT15 0.88 11.59 0.54 2.45e-26 Tuberculosis; LUSC cis rs1858037 0.867 rs1553675 chr2:65570307 C/T cg08085232 chr2:65598271 SPRED2 0.39 5.91 0.31 8.43e-9 Rheumatoid arthritis; LUSC trans rs11098499 0.779 rs10011097 chr4:120310359 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.13 0.32 2.49e-9 Corneal astigmatism; LUSC trans rs7824557 0.836 rs2736378 chr8:11119760 G/A cg15556689 chr8:8085844 FLJ10661 -0.58 -9.33 -0.45 1.55e-18 Retinal vascular caliber; LUSC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -8.16 -0.41 7.03e-15 Body mass index (adult); LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg03579872 chr1:53393473 SCP2 -0.39 -5.77 -0.3 1.86e-8 Monocyte count; LUSC cis rs7215564 0.908 rs4889783 chr17:78667160 C/T cg23238734 chr17:78661607 RPTOR 0.49 6.43 0.33 4.46e-10 Myopia (pathological); LUSC cis rs2357013 0.752 rs12474925 chr2:53176117 C/A cg07782112 chr2:53107842 NA -0.39 -6.25 -0.32 1.23e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs354225 0.565 rs2971880 chr2:54885640 A/T cg26097391 chr2:54893211 SPTBN1 0.4 6.65 0.34 1.22e-10 Schizophrenia; LUSC cis rs4664304 0.903 rs72957576 chr2:160754132 A/C cg03641300 chr2:160917029 PLA2R1 -0.4 -6.48 -0.33 3.26e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg24838063 chr12:130822603 PIWIL1 0.69 10.11 0.48 3.78e-21 Menopause (age at onset); LUSC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg24209194 chr3:40518798 ZNF619 0.46 6.17 0.32 1.95e-9 Renal cell carcinoma; LUSC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg25456477 chr12:86230367 RASSF9 0.33 5.71 0.3 2.53e-8 Major depressive disorder; LUSC cis rs782590 0.643 rs5012561 chr2:55742032 G/C cg18811423 chr2:55921094 PNPT1 -0.64 -9.03 -0.44 1.38e-17 Metabolic syndrome; LUSC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg19046167 chr17:80928561 B3GNTL1 -0.37 -6.02 -0.31 4.52e-9 Glycated hemoglobin levels; LUSC cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.88 0.31 9.75e-9 Rheumatoid arthritis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15687138 chr1:151138326 SCNM1;LYSMD1 0.4 6.29 0.33 9.77e-10 Triglycerides; LUSC cis rs7575217 0.670 rs2592392 chr2:101723343 A/G cg23907051 chr2:101730305 TBC1D8 0.28 7.5 0.38 5.79e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg13798780 chr7:105162888 PUS7 0.56 6.04 0.31 4.06e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7584330 0.518 rs77789507 chr2:238440972 C/T cg16989719 chr2:238392110 NA -0.5 -6.3 -0.33 9.42e-10 Prostate cancer; LUSC cis rs7089973 0.624 rs1359080 chr10:116582419 C/A cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.18e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs763121 0.719 rs138699 chr22:39129708 G/A cg06022373 chr22:39101656 GTPBP1 0.71 10.27 0.49 1.1e-21 Menopause (age at onset); LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg07362569 chr17:61921086 SMARCD2 0.37 7.61 0.38 2.87e-13 Prudent dietary pattern; LUSC trans rs11098499 0.863 rs34868248 chr4:120442430 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.64 0.39 2.3e-13 Corneal astigmatism; LUSC cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 7.08 0.36 8.51e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8017423 0.967 rs61592400 chr14:90703252 T/C cg04374321 chr14:90722782 PSMC1 0.75 12.1 0.55 3.52e-28 Mortality in heart failure; LUSC cis rs6754311 0.597 rs2082729 chr2:136550109 C/T cg25344623 chr2:136566232 LCT 0.38 5.69 0.3 2.76e-8 Mosquito bite size; LUSC cis rs9300255 0.602 rs2695479 chr12:123689386 T/C cg00376283 chr12:123451042 ABCB9 0.7 7.92 0.4 3.67e-14 Neutrophil percentage of white cells; LUSC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg25019033 chr10:957182 NA -0.51 -7.0 -0.36 1.38e-11 Eosinophil percentage of granulocytes; LUSC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg03806693 chr22:41940476 POLR3H -0.87 -12.53 -0.57 8.73e-30 Vitiligo; LUSC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg13535736 chr9:111863775 C9orf5 0.38 6.02 0.31 4.5e-9 Menarche (age at onset); LUSC cis rs9400467 0.528 rs459403 chr6:111653877 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.69 -0.34 9.43e-11 Blood metabolite levels;Amino acid levels; LUSC trans rs2739330 0.796 rs5760097 chr22:24247794 G/C cg06437703 chr8:37914619 EIF4EBP1 -0.57 -8.89 -0.44 3.92e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs75920871 0.748 rs61905689 chr11:116869217 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.52 -5.91 -0.31 8.23e-9 Subjective well-being; LUSC trans rs208520 0.690 rs851467 chr6:66802721 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.61 -0.69 1.49e-49 Exhaled nitric oxide output; LUSC cis rs2667011 0.512 rs10929960 chr2:160815141 A/C cg06573604 chr2:160760825 LY75 0.45 6.27 0.32 1.14e-9 Bilirubin levels; LUSC cis rs273573 1.000 rs158505 chr11:30981248 T/C cg14844989 chr11:31128820 NA 0.38 6.11 0.32 2.84e-9 Total body bone mineral density; LUSC trans rs9380880 0.826 rs12198307 chr6:39550197 C/T cg09045552 chr2:169506620 LASS6 0.73 6.56 0.34 2.11e-10 Immune response to smallpox vaccine (IL-6); LUSC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.62 0.34 1.44e-10 Systemic lupus erythematosus; LUSC cis rs11711311 0.955 rs2124105 chr3:113406003 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.98 -0.31 5.86e-9 IgG glycosylation; LUSC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 12.6 0.57 4.85e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs427394 0.664 rs274722 chr5:6718668 C/T cg25011763 chr5:6727354 POLS -0.37 -6.43 -0.33 4.3e-10 Menopause (age at onset); LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg14004847 chr7:1930337 MAD1L1 0.5 7.68 0.39 1.83e-13 Bipolar disorder and schizophrenia; LUSC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg26513180 chr16:89883248 FANCA 0.79 6.37 0.33 6.26e-10 Skin colour saturation; LUSC cis rs9473147 0.516 rs9349416 chr6:47551938 G/A cg12968598 chr6:47444699 CD2AP 0.52 7.93 0.4 3.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs6121246 0.559 rs6087771 chr20:30306724 A/G cg13852791 chr20:30311386 BCL2L1 0.94 14.43 0.62 5.13e-37 Mean corpuscular hemoglobin; LUSC trans rs6601327 0.573 rs13278824 chr8:9646119 T/A cg06636001 chr8:8085503 FLJ10661 0.51 7.52 0.38 5.26e-13 Multiple myeloma (hyperdiploidy); LUSC trans rs561341 1.000 rs527256 chr17:30321293 C/G cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs1570884 0.556 rs2146146 chr13:50170368 C/T cg03651054 chr13:50194643 NA 0.36 6.2 0.32 1.71e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs877282 0.898 rs12356709 chr10:763365 A/G cg17470449 chr10:769945 NA 0.53 7.13 0.36 6.24e-12 Uric acid levels; LUSC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.13e-16 Intelligence (multi-trait analysis); LUSC cis rs478304 0.934 rs1193496 chr11:65537556 C/T cg05805236 chr11:65401703 PCNXL3 -0.38 -6.39 -0.33 5.47e-10 Acne (severe); LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg08736216 chr1:53307985 ZYG11A -0.3 -6.51 -0.34 2.8e-10 Monocyte count; LUSC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg11890956 chr21:40555474 PSMG1 1.0 18.39 0.71 1.19e-52 Cognitive function; LUSC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg25124228 chr12:125621409 AACS -0.55 -8.34 -0.42 1.97e-15 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12310956 0.532 rs1525904 chr12:33962448 T/C cg06521331 chr12:34319734 NA -0.45 -7.21 -0.37 3.74e-12 Morning vs. evening chronotype; LUSC cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg21573476 chr21:45109991 RRP1B 0.39 6.31 0.33 9.08e-10 Mean corpuscular volume; LUSC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC trans rs17685 0.753 rs1639617 chr7:75701728 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.75 0.73 4.46e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg00745463 chr17:30367425 LRRC37B -0.64 -8.13 -0.41 8.64e-15 Hip circumference adjusted for BMI; LUSC cis rs1448094 0.933 rs11117102 chr12:86312720 A/C cg00310523 chr12:86230176 RASSF9 0.4 7.15 0.36 5.35e-12 Major depressive disorder; LUSC cis rs7923609 0.935 rs10995477 chr10:65010672 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.59 -0.34 1.72e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs7615952 0.576 rs6804482 chr3:125815762 C/T cg07211511 chr3:129823064 LOC729375 -0.75 -9.75 -0.47 6.42e-20 Blood pressure (smoking interaction); LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.81 0.47 4.05e-20 Bipolar disorder; LUSC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg17330251 chr7:94953956 PON1 -0.38 -5.92 -0.31 7.8e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10465746 0.935 rs4258241 chr1:84437929 G/A cg10977910 chr1:84465055 TTLL7 0.41 6.05 0.31 3.81e-9 Obesity-related traits; LUSC cis rs12900413 0.687 rs8035472 chr15:90313432 T/C cg24249390 chr15:90295951 MESP1 -0.37 -5.9 -0.31 8.74e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs17818399 0.510 rs1451153 chr2:46799852 G/T cg02822958 chr2:46747628 ATP6V1E2 0.41 6.83 0.35 4.05e-11 Height; LUSC cis rs6951245 0.882 rs10252404 chr7:1209607 C/A cg24642844 chr7:1081250 C7orf50 -0.76 -10.03 -0.48 7.28e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg26304593 chr6:42947056 PEX6 -0.49 -7.33 -0.37 1.74e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6496667 0.600 rs28674812 chr15:91077809 G/T cg04176472 chr15:90893244 GABARAPL3 0.39 5.7 0.3 2.65e-8 Rheumatoid arthritis; LUSC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.81 12.1 0.55 3.33e-28 Cognitive test performance; LUSC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg11645453 chr3:52864694 ITIH4 0.39 9.35 0.46 1.31e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg21724239 chr8:58056113 NA 0.76 8.17 0.41 6.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs7089973 0.604 rs7915943 chr10:116618077 G/A cg23260525 chr10:116636907 FAM160B1 0.44 9.43 0.46 7.04e-19 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs79349575 0.783 rs62075852 chr17:47017176 T/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs3008870 0.755 rs11208974 chr1:67398119 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.74 12.09 0.55 3.59e-28 Lymphocyte percentage of white cells; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13155599 chr4:120221765 C4orf3 -0.48 -5.95 -0.31 6.62e-9 Bipolar disorder and schizophrenia; LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.67 0.6 4.32e-34 Alzheimer's disease; LUSC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.37 0.37 1.32e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg05368731 chr17:41323189 NBR1 0.92 15.84 0.66 1.49e-42 Menopause (age at onset); LUSC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs10782582 0.609 rs1159215 chr1:76317869 A/T cg03433033 chr1:76189801 ACADM -0.4 -6.05 -0.31 3.89e-9 Daytime sleep phenotypes; LUSC cis rs7084921 0.608 rs2862950 chr10:101844785 A/G cg11888571 chr10:102027403 CWF19L1 -0.45 -6.23 -0.32 1.44e-9 Bone mineral density; LUSC cis rs8064299 0.597 rs3785539 chr17:72775099 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.91 17.9 0.7 1.06e-50 Monocyte count; LUSC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.42 7.96 0.4 2.79e-14 Monocyte percentage of white cells; LUSC cis rs7264396 0.563 rs2425103 chr20:34312329 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.61 -0.43 2.97e-16 Total cholesterol levels; LUSC cis rs7193541 0.673 rs12716769 chr16:74652537 T/C cg01733217 chr16:74700730 RFWD3 1.02 23.17 0.79 1.77e-71 Multiple myeloma; LUSC cis rs2204008 0.546 rs11519978 chr12:37998170 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.76 0.65 3.19e-42 Bladder cancer; LUSC cis rs7647973 0.626 rs1996664 chr3:49878395 A/G cg03060546 chr3:49711283 APEH -0.62 -7.29 -0.37 2.32e-12 Menarche (age at onset); LUSC cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg22117172 chr7:91764530 CYP51A1 0.31 5.7 0.3 2.7e-8 Breast cancer; LUSC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg20307385 chr11:47447363 PSMC3 -0.45 -5.9 -0.31 8.95e-9 Subjective well-being; LUSC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg20135002 chr11:47629003 NA -0.51 -8.1 -0.41 1.06e-14 Subjective well-being; LUSC cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg08069147 chr6:88032118 GJB7;C6orf162 0.59 8.69 0.43 1.71e-16 Monocyte percentage of white cells; LUSC cis rs2295359 1.000 rs11209006 chr1:67619259 T/G cg12940439 chr1:67600707 NA 0.35 6.12 0.32 2.56e-9 Psoriasis; LUSC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.41 -0.33 4.86e-10 Lung cancer; LUSC cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.76 -0.3 1.88e-8 IgG glycosylation; LUSC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7818345 1.000 rs6984145 chr8:19294111 A/G cg11303988 chr8:19266685 CSGALNACT1 0.38 7.17 0.37 4.73e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs2637266 0.626 rs2583067 chr10:78555804 A/G cg18941641 chr10:78392320 NA 0.38 7.03 0.36 1.19e-11 Pulmonary function; LUSC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg06808227 chr14:105710500 BRF1 0.66 10.17 0.49 2.49e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.71 11.86 0.54 2.68e-27 Prudent dietary pattern; LUSC cis rs11098499 0.863 rs1552095 chr4:120460306 A/G cg09307838 chr4:120376055 NA 0.76 10.41 0.49 3.77e-22 Corneal astigmatism; LUSC cis rs3540 0.597 rs3743409 chr15:91045539 T/A cg10434728 chr15:90938212 IQGAP1 -0.45 -9.14 -0.45 6.2e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs1908814 0.516 rs4840597 chr8:11796068 A/C cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.74e-15 Neuroticism; LUSC cis rs3106136 0.527 rs2632411 chr4:95149434 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.54 -0.42 4.89e-16 Capecitabine sensitivity; LUSC cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.16 0.32 2.1e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg10018233 chr7:150070692 REPIN1 0.39 6.42 0.33 4.81e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs1538970 0.781 rs713358 chr1:45988267 C/G cg05343316 chr1:45956843 TESK2 0.72 9.75 0.47 6.34e-20 Platelet count; LUSC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg04546413 chr19:29218101 NA 0.62 8.12 0.41 8.94e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7615316 0.844 rs13069307 chr3:142315074 G/A cg16271453 chr3:142027066 XRN1 -0.36 -6.03 -0.31 4.41e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg15147215 chr3:52552868 STAB1 -0.29 -5.74 -0.3 2.09e-8 Electroencephalogram traits; LUSC cis rs7914558 0.966 rs12766205 chr10:104893568 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.53 0.46 3.28e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg12432903 chr7:1882776 MAD1L1 -0.39 -6.2 -0.32 1.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs6714710 0.603 rs7583868 chr2:98588372 C/A cg26665480 chr2:98280029 ACTR1B 0.56 8.1 0.41 1.06e-14 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs11671005 0.735 rs12977592 chr19:58961056 C/G cg13877915 chr19:58951672 ZNF132 0.44 5.83 0.3 1.32e-8 Mean platelet volume; LUSC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg25173405 chr17:45401733 C17orf57 -0.4 -5.97 -0.31 5.91e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs7830057 0.786 rs28444271 chr8:101438231 C/T cg18795127 chr10:135212911 MTG1 -0.41 -6.06 -0.31 3.76e-9 Asthma; LUSC cis rs6484504 0.576 rs208072 chr11:31141288 A/G cg26647111 chr11:31128758 NA 0.41 6.04 0.31 4.07e-9 Red blood cell count; LUSC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg14895029 chr7:2775587 GNA12 -0.4 -6.08 -0.32 3.24e-9 Height; LUSC cis rs6964587 0.773 rs2097810 chr7:91977226 G/A cg17063962 chr7:91808500 NA 0.53 7.59 0.38 3.19e-13 Breast cancer; LUSC trans rs1927790 0.727 rs4771932 chr13:96950542 G/A cg03198741 chr6:1003969 LOC285768 -0.4 -5.99 -0.31 5.52e-9 Body mass index; LUSC cis rs10761482 0.701 rs12411733 chr10:62123046 A/G cg18175470 chr10:62150864 ANK3 -0.42 -6.3 -0.33 9.19e-10 Schizophrenia; LUSC cis rs9527 0.640 rs7089061 chr10:104723015 C/A cg05855489 chr10:104503620 C10orf26 0.52 8.08 0.4 1.19e-14 Arsenic metabolism; LUSC cis rs12908161 0.959 rs61074241 chr15:85333396 C/T cg17173187 chr15:85201210 NMB 0.5 8.75 0.43 1.09e-16 Schizophrenia; LUSC cis rs2425143 1.000 rs6060639 chr20:34438183 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -6.11 -0.32 2.85e-9 Blood protein levels; LUSC trans rs12571093 0.803 rs61854829 chr10:70033043 A/G cg04882175 chr6:131122610 NA -0.57 -6.55 -0.34 2.23e-10 Optic nerve measurement (disc area); LUSC cis rs34526934 0.608 rs2857539 chr2:177024863 G/A cg26754761 chr2:177040938 NA -0.39 -7.64 -0.39 2.34e-13 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg14895029 chr7:2775587 GNA12 -0.36 -5.67 -0.3 3.05e-8 Height; LUSC cis rs9527 0.590 rs10883836 chr10:104891198 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg21918786 chr6:109611834 NA -0.36 -6.25 -0.32 1.25e-9 Reticulocyte fraction of red cells; LUSC cis rs597583 1.000 rs521609 chr11:117407301 C/T cg27161313 chr11:117392002 DSCAML1 -0.39 -6.63 -0.34 1.33e-10 Putamen volume; LUSC cis rs12760731 0.565 rs11580064 chr1:178226520 A/G cg00404053 chr1:178313656 RASAL2 0.65 6.66 0.34 1.12e-10 Obesity-related traits; LUSC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg18230493 chr5:56204884 C5orf35 0.77 12.52 0.57 9.66e-30 Initial pursuit acceleration; LUSC cis rs9503598 0.714 rs7758776 chr6:3452245 C/T cg00476032 chr6:3446245 SLC22A23 0.39 8.31 0.41 2.52e-15 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs244731 0.959 rs10037110 chr5:176658066 A/T cg17509989 chr5:176798049 RGS14 -0.68 -9.35 -0.46 1.26e-18 Urate levels in lean individuals; LUSC cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.3 0.69 2.6e-48 Chronic sinus infection; LUSC cis rs2721195 0.549 rs2620666 chr8:145703413 T/C cg26752003 chr8:145688521 CYHR1 -0.68 -11.68 -0.54 1.14e-26 Age at first birth; LUSC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg22875332 chr1:76189707 ACADM 0.83 14.05 0.61 1.51e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg06713675 chr4:122721982 EXOSC9 -0.57 -9.88 -0.48 2.29e-20 Type 2 diabetes; LUSC cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg01448562 chr3:133502909 NA -0.58 -9.11 -0.45 7.96e-18 Alcohol consumption (transferrin glycosylation); LUSC cis rs897984 0.568 rs72799330 chr16:30893555 C/A cg02466173 chr16:30829666 NA -0.53 -8.69 -0.43 1.69e-16 Dementia with Lewy bodies; LUSC cis rs4766646 0.542 rs7963600 chr12:110276689 A/C cg10794374 chr12:110278745 NA -0.29 -6.25 -0.32 1.26e-9 Metabolite levels (MHPG); LUSC cis rs951366 0.576 rs7513645 chr1:205698026 A/G cg07167872 chr1:205819463 PM20D1 0.43 5.92 0.31 7.89e-9 Menarche (age at onset); LUSC cis rs59698941 0.882 rs56353702 chr5:132248575 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg23172400 chr8:95962367 TP53INP1 -0.3 -5.82 -0.3 1.35e-8 Type 2 diabetes; LUSC cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg00074818 chr8:8560427 CLDN23 0.59 9.95 0.48 1.32e-20 Obesity-related traits; LUSC cis rs11098499 0.754 rs10212775 chr4:120239244 G/C cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC cis rs738321 0.757 rs3788535 chr22:38534045 T/C cg25457927 chr22:38595422 NA -0.38 -7.18 -0.37 4.69e-12 Breast cancer; LUSC cis rs1256061 0.603 rs1256037 chr14:64743301 G/A cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.18e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs8017423 0.904 rs4603489 chr14:90760607 A/G cg14092571 chr14:90743983 NA 0.35 5.65 0.3 3.37e-8 Mortality in heart failure; LUSC cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg18252515 chr7:66147081 NA 1.14 13.35 0.59 6.87e-33 Diabetic kidney disease; LUSC cis rs9361491 0.508 rs9343787 chr6:79415606 A/C cg05283184 chr6:79620031 NA -0.39 -6.9 -0.35 2.66e-11 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.966 rs4934538 chr10:35472150 T/C cg04310649 chr10:35416472 CREM -0.42 -6.43 -0.33 4.42e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg22920501 chr2:26401640 FAM59B -0.73 -10.49 -0.5 1.97e-22 Gut microbiome composition (summer); LUSC cis rs10751667 0.643 rs7394524 chr11:933865 T/C ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs936229 0.705 rs936227 chr15:75131959 A/G cg10253484 chr15:75165896 SCAMP2 -0.44 -6.19 -0.32 1.73e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg03188948 chr7:1209495 NA 0.4 5.92 0.31 8.08e-9 Longevity;Endometriosis; LUSC cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.31e-9 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6500395 0.890 rs11861666 chr16:48679914 G/T cg04672837 chr16:48644449 N4BP1 0.44 6.35 0.33 6.99e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg21573476 chr21:45109991 RRP1B -0.4 -6.42 -0.33 4.78e-10 Mean corpuscular volume; LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg17724175 chr1:150552817 MCL1 0.36 6.53 0.34 2.45e-10 Tonsillectomy; LUSC cis rs11603020 0.950 rs11229063 chr11:57369730 G/A cg23127183 chr11:57508653 C11orf31 -0.46 -6.37 -0.33 6.21e-10 Blood protein levels; LUSC cis rs59104589 0.535 rs73002160 chr2:242321707 A/C cg14842376 chr2:242211374 HDLBP 0.56 6.53 0.34 2.48e-10 Fibrinogen levels; LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg27170947 chr2:26402098 FAM59B 0.64 8.95 0.44 2.53e-17 Gut microbiome composition (summer); LUSC cis rs3126085 0.935 rs10888468 chr1:152181539 C/T cg03465714 chr1:152285911 FLG -0.42 -5.85 -0.3 1.17e-8 Atopic dermatitis; LUSC cis rs6942756 0.956 rs7792317 chr7:128963971 G/A cg02491457 chr7:128862824 NA -0.48 -6.47 -0.33 3.56e-10 White matter hyperintensity burden; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23441208 chr19:49314192 BCAT2 -0.39 -5.98 -0.31 5.8e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs698813 0.604 rs7565928 chr2:44489956 T/C cg00619915 chr2:44497795 NA -0.54 -7.49 -0.38 6.35e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg02187348 chr16:89574699 SPG7 0.52 7.08 0.36 8.72e-12 Multiple myeloma (IgH translocation); LUSC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg16228356 chr17:43848958 NA -0.29 -6.21 -0.32 1.55e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs4343996 0.840 rs4131987 chr7:3380895 C/T cg21248987 chr7:3385318 SDK1 -0.42 -6.94 -0.36 2e-11 Motion sickness; LUSC cis rs9399135 0.933 rs28384512 chr6:135376232 C/T cg24558204 chr6:135376177 HBS1L 0.58 8.82 0.43 6.45e-17 Red blood cell count; LUSC cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.45 0.42 9.3e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.97 -0.4 2.62e-14 Lymphocyte counts; LUSC cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.47e-8 Breast cancer; LUSC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg13390004 chr1:15929781 NA 0.42 7.04 0.36 1.07e-11 Systolic blood pressure; LUSC cis rs977987 0.806 rs4146809 chr16:75415775 A/G cg03315344 chr16:75512273 CHST6 -0.47 -8.8 -0.43 7.48e-17 Dupuytren's disease; LUSC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06544989 chr22:39130855 UNC84B 0.33 5.87 0.31 1.07e-8 Menopause (age at onset); LUSC trans rs1493916 0.967 rs1389532 chr18:31392323 C/T cg15819921 chr19:927150 ARID3A -0.44 -6.42 -0.33 4.77e-10 Life satisfaction; LUSC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg09904177 chr6:26538194 HMGN4 -0.44 -6.51 -0.34 2.7e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7590720 1.000 rs7592663 chr2:216894978 T/C cg12620499 chr2:216877984 MREG 0.9 13.84 0.6 9.37e-35 Alcohol dependence; LUSC cis rs920590 0.721 rs920587 chr8:19663339 C/A cg03894339 chr8:19674705 INTS10 0.5 6.77 0.35 5.76e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs4144743 1.000 rs4144743 chr17:45323125 A/G cg18085866 chr17:45331354 ITGB3 -0.68 -7.6 -0.38 3.03e-13 Body mass index; LUSC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC trans rs853679 0.517 rs4713150 chr6:28136212 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC trans rs72742734 0.731 rs2302955 chr5:32735532 T/A cg16345559 chr2:213933386 IKZF2 -0.66 -6.01 -0.31 4.84e-9 Height; LUSC cis rs8141797 0.901 rs76376425 chr22:24523177 C/T cg00411358 chr22:24577142 SUSD2 -0.58 -5.75 -0.3 1.97e-8 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg24675658 chr1:53192096 ZYG11B -0.7 -11.57 -0.53 2.96e-26 Monocyte count; LUSC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg03433033 chr1:76189801 ACADM 0.83 14.58 0.62 1.35e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs79349575 0.783 rs11079844 chr17:47028334 G/A cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC trans rs459571 0.920 rs417142 chr9:136891370 G/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -12.39 -0.56 2.77e-29 Platelet distribution width; LUSC cis rs754466 0.914 rs4595491 chr10:79685833 G/A cg17075019 chr10:79541650 NA -0.63 -8.23 -0.41 4.17e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg02772935 chr3:125709198 NA -0.49 -5.88 -0.31 9.95e-9 Blood pressure (smoking interaction); LUSC cis rs4595586 0.545 rs3858554 chr12:39381460 C/T cg13010199 chr12:38710504 ALG10B 0.41 6.03 0.31 4.46e-9 Morning vs. evening chronotype; LUSC cis rs8044995 0.501 rs55793998 chr16:68378985 G/T cg09835421 chr16:68378352 PRMT7 -0.76 -8.71 -0.43 1.47e-16 Schizophrenia; LUSC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg11812906 chr14:75593930 NEK9 0.64 10.47 0.5 2.28e-22 Height; LUSC trans rs11671005 0.504 rs2305119 chr19:59067623 C/T cg22037779 chr5:139682734 PFDN1 -0.56 -7.31 -0.37 1.96e-12 Mean platelet volume; LUSC cis rs10751667 0.643 rs10794350 chr11:946070 A/G ch.11.42038R chr11:967971 AP2A2 0.41 6.01 0.31 4.97e-9 Alzheimer's disease (late onset); LUSC cis rs12421382 0.659 rs1371331 chr11:109382578 G/A cg11473876 chr11:109292803 C11orf87 0.41 6.58 0.34 1.78e-10 Schizophrenia; LUSC cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg08807101 chr21:30365312 RNF160 0.71 11.66 0.54 1.4e-26 Selective IgA deficiency; LUSC cis rs7927771 0.524 rs7116346 chr11:47883880 G/A cg20307385 chr11:47447363 PSMC3 -0.47 -7.02 -0.36 1.24e-11 Subjective well-being; LUSC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg06634786 chr22:41940651 POLR3H -0.57 -6.44 -0.33 4.11e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs11098499 0.604 rs34278750 chr4:120571136 G/A cg25214090 chr10:38739885 LOC399744 0.5 7.32 0.37 1.88e-12 Corneal astigmatism; LUSC cis rs7572733 0.534 rs6434943 chr2:198762192 T/G cg00792783 chr2:198669748 PLCL1 0.46 6.13 0.32 2.47e-9 Dermatomyositis; LUSC cis rs4343996 1.000 rs10238520 chr7:3341615 G/A cg21248987 chr7:3385318 SDK1 0.4 6.83 0.35 4.07e-11 Motion sickness; LUSC cis rs2200578 1.000 rs72961173 chr2:99886868 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 0.61 7.16 0.36 5.11e-12 IgG glycosylation; LUSC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg22875332 chr1:76189707 ACADM -0.75 -10.27 -0.49 1.06e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.42 5.97 0.31 5.95e-9 Schizophrenia; LUSC cis rs72960926 0.744 rs72952275 chr6:74926492 A/G cg03266952 chr6:74778945 NA -0.84 -7.01 -0.36 1.34e-11 Metabolite levels (MHPG); LUSC cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg13390004 chr1:15929781 NA 0.36 6.09 0.32 3.05e-9 Systolic blood pressure; LUSC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg22903471 chr2:27725779 GCKR -0.4 -6.79 -0.35 5.14e-11 Total body bone mineral density; LUSC cis rs10089 1.000 rs4835941 chr5:127430905 C/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.84 -0.3 1.21e-8 Ileal carcinoids; LUSC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg03517284 chr6:25882590 NA -0.43 -7.39 -0.38 1.16e-12 Intelligence (multi-trait analysis); LUSC cis rs6489785 0.687 rs3213567 chr12:121222556 T/C cg02403541 chr12:121454288 C12orf43 0.39 5.75 0.3 2.03e-8 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs240764 0.853 rs10457808 chr6:100979506 A/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.47e-10 Neuroticism; LUSC cis rs11264799 0.554 rs59424684 chr1:157586990 G/A cg18268488 chr1:157545234 FCRL4 0.36 6.21 0.32 1.61e-9 IgA nephropathy; LUSC cis rs9868809 0.505 rs9877685 chr3:48748588 C/T cg00383909 chr3:49044727 WDR6 1.14 10.58 0.5 9.36e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg06008330 chr7:65541103 ASL -0.41 -6.39 -0.33 5.74e-10 Aortic root size; LUSC cis rs2637266 0.655 rs861744 chr10:78519132 T/G cg18941641 chr10:78392320 NA 0.39 7.12 0.36 6.8e-12 Pulmonary function; LUSC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg14773178 chr5:1868261 NA 0.33 6.26 0.32 1.19e-9 Cardiovascular disease risk factors; LUSC cis rs6750795 0.569 rs1667305 chr2:232403829 A/G cg19187155 chr2:232395269 NMUR1 0.78 13.42 0.59 3.95e-33 Height; LUSC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg09877947 chr5:131593287 PDLIM4 0.4 6.89 0.35 2.72e-11 Blood metabolite levels; LUSC cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg05868516 chr6:26286170 HIST1H4H 0.37 6.09 0.32 3.03e-9 Educational attainment; LUSC cis rs9309473 1.000 rs7576245 chr2:73829678 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.57 -0.34 1.9e-10 Metabolite levels; LUSC cis rs9522267 0.535 rs2039916 chr13:112238863 A/C cg10483660 chr13:112241077 NA -0.31 -5.77 -0.3 1.8e-8 Hepatitis; LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg03934478 chr11:495069 RNH1 0.84 10.03 0.48 7.17e-21 Body mass index; LUSC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg02807482 chr3:125708958 NA -0.52 -6.54 -0.34 2.26e-10 Blood pressure (smoking interaction); LUSC cis rs9549260 0.709 rs9549240 chr13:41186644 T/G cg21288729 chr13:41239152 FOXO1 0.59 9.07 0.44 1.07e-17 Red blood cell count; LUSC trans rs7824557 0.806 rs10503418 chr8:11118983 C/T cg15556689 chr8:8085844 FLJ10661 -0.58 -9.31 -0.45 1.78e-18 Retinal vascular caliber; LUSC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.34 0.67 1.6e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs60843830 1.000 rs62114497 chr2:214837 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.62 9.9 0.48 1.96e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg05347473 chr6:146136440 FBXO30 0.57 9.96 0.48 1.23e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg23583168 chr7:148888333 NA -0.9 -17.19 -0.69 7.1e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.62 -6.31 -0.33 8.99e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs17270561 0.579 rs10456326 chr6:25919662 G/A cg17691542 chr6:26056736 HIST1H1C 0.99 12.8 0.57 8.78e-31 Iron status biomarkers; LUSC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.51 7.51 0.38 5.38e-13 Personality dimensions; LUSC cis rs13242816 1.000 rs13247987 chr7:116113344 A/C cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs1891275 0.515 rs10881957 chr10:93501876 C/T cg07889827 chr10:93443413 NA -0.39 -8.93 -0.44 2.87e-17 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.966 rs7077242 chr10:35481965 A/C cg03585969 chr10:35415529 CREM -0.63 -9.29 -0.45 2.04e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.81 0.39 7.29e-14 Calcium levels; LUSC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg26597838 chr10:835615 NA 0.74 8.84 0.44 5.41e-17 Eosinophil percentage of granulocytes; LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg16606324 chr3:10149918 C3orf24 0.61 8.02 0.4 1.8e-14 Alzheimer's disease; LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.73 -0.57 1.62e-30 Alzheimer's disease; LUSC trans rs6502050 0.835 rs8070014 chr17:80115247 T/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg21856205 chr7:94953877 PON1 -0.36 -5.94 -0.31 7.32e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg05115182 chr10:99496889 ZFYVE27 0.46 6.11 0.32 2.82e-9 Thyroid stimulating hormone; LUSC cis rs7264396 0.887 rs224351 chr20:34052273 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.66 -0.34 1.1e-10 Total cholesterol levels; LUSC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg14196790 chr5:131705035 SLC22A5 -0.46 -7.93 -0.4 3.37e-14 Blood metabolite levels; LUSC cis rs7589342 0.899 rs10185551 chr2:106492201 A/C cg16077055 chr2:106428750 NCK2 0.32 5.98 0.31 5.61e-9 Addiction; LUSC cis rs921968 0.519 rs62191659 chr2:219630510 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.15 -0.49 2.88e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg09044154 chr16:88155775 NA -0.56 -7.54 -0.38 4.39e-13 Menopause (age at onset); LUSC cis rs1712517 0.844 rs1163075 chr10:105021263 A/G cg05636881 chr10:105038444 INA -0.37 -6.16 -0.32 2.03e-9 Migraine; LUSC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg05738196 chr6:26577821 NA 0.56 6.94 0.36 1.99e-11 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.09 0.32 3.02e-9 Menopause (age at onset); LUSC cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg03146154 chr1:46216737 IPP 0.53 7.74 0.39 1.21e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg09469691 chr10:81107165 PPIF 0.64 10.27 0.49 1.06e-21 Height; LUSC cis rs826838 1.000 rs826892 chr12:39100790 T/C cg13010199 chr12:38710504 ALG10B -0.64 -10.89 -0.51 7.99e-24 Heart rate; LUSC cis rs7944584 0.511 rs10838725 chr11:47557871 T/C cg20307385 chr11:47447363 PSMC3 0.87 13.93 0.61 4.29e-35 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg07507251 chr3:52567010 NT5DC2 0.38 7.78 0.39 9.21e-14 Electroencephalogram traits; LUSC cis rs796825 0.530 rs6771116 chr3:120001314 A/G cg21790991 chr3:120137480 FSTL1 -0.33 -6.05 -0.31 3.78e-9 HIV-1 susceptibility; LUSC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs546131 0.928 rs552171 chr11:34830709 G/T cg06937548 chr11:34938143 PDHX;APIP 0.48 6.58 0.34 1.84e-10 Lung disease severity in cystic fibrosis; LUSC cis rs911555 0.504 rs4906340 chr14:104076645 G/A cg12935359 chr14:103987150 CKB 0.47 7.03 0.36 1.15e-11 Intelligence (multi-trait analysis); LUSC cis rs78366141 0.649 rs76884708 chr4:89692043 G/C cg01026744 chr4:89619053 NAP1L5;HERC3 0.86 7.14 0.36 5.92e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg05855489 chr10:104503620 C10orf26 -0.68 -9.77 -0.47 5.43e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.41 0.33 5.09e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10782582 0.593 rs11801414 chr1:76124517 G/A cg03433033 chr1:76189801 ACADM -0.45 -6.84 -0.35 3.86e-11 Daytime sleep phenotypes; LUSC cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg14530993 chr4:882597 GAK 0.7 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg10018233 chr7:150070692 REPIN1 0.34 5.66 0.3 3.19e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9399135 0.967 rs2327578 chr6:135329969 C/T cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Red blood cell count; LUSC cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24023847 chr6:119256284 MCM9 -0.47 -7.15 -0.36 5.63e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg20821713 chr7:1055600 C7orf50 -0.52 -6.75 -0.35 6.39e-11 Bronchopulmonary dysplasia; LUSC cis rs6430585 0.528 rs309154 chr2:136726567 C/T cg07169764 chr2:136633963 MCM6 1.06 16.05 0.66 2.25e-43 Corneal structure; LUSC cis rs738322 1.000 rs4382 chr22:38570842 T/C cg25457927 chr22:38595422 NA -0.42 -8.92 -0.44 3.05e-17 Cutaneous nevi; LUSC cis rs7107174 1.000 rs10899486 chr11:78072398 A/G cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg05874882 chr4:1763078 NA 0.53 8.76 0.43 1.03e-16 Bladder cancer;Urinary bladder cancer; LUSC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg01879757 chr17:41196368 BRCA1 -0.47 -7.07 -0.36 8.95e-12 Menopause (age at onset); LUSC cis rs6430585 0.527 rs59413285 chr2:136444185 G/T cg07169764 chr2:136633963 MCM6 1.05 14.07 0.61 1.21e-35 Corneal structure; LUSC cis rs7582180 0.874 rs7601442 chr2:100897351 T/A cg08017756 chr2:100939284 LONRF2 -0.37 -6.18 -0.32 1.83e-9 Intelligence (multi-trait analysis); LUSC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg25811766 chr13:21894605 NA 0.78 9.61 0.47 1.8e-19 White matter hyperintensity burden; LUSC cis rs5769707 0.681 rs6009803 chr22:50051007 A/G cg20744362 chr22:50050164 C22orf34 0.38 7.01 0.36 1.36e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.55e-10 Life satisfaction; LUSC cis rs2832077 0.527 rs9981922 chr21:30212718 A/G cg24692254 chr21:30365293 RNF160 -0.62 -9.89 -0.48 2.21e-20 Cognitive test performance; LUSC cis rs7929679 0.521 rs10768094 chr11:34792189 C/T cg06937548 chr11:34938143 PDHX;APIP 0.4 5.91 0.31 8.29e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs4919694 0.901 rs74376228 chr10:104677662 G/C cg04362960 chr10:104952993 NT5C2 1.17 13.48 0.59 2.36e-33 Arsenic metabolism; LUSC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -9.95 -0.48 1.35e-20 Glomerular filtration rate (creatinine); LUSC cis rs72960926 0.744 rs67280742 chr6:75004753 T/C cg03266952 chr6:74778945 NA -0.75 -6.61 -0.34 1.48e-10 Metabolite levels (MHPG); LUSC trans rs372883 0.506 rs2832300 chr21:30749315 A/G cg14791747 chr16:20752902 THUMPD1 -0.41 -5.96 -0.31 6.3e-9 Pancreatic cancer; LUSC trans rs12579753 0.879 rs7958566 chr12:82131478 A/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.57 -0.34 1.88e-10 Resting heart rate; LUSC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg17366294 chr4:99064904 C4orf37 0.53 8.64 0.43 2.32e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg00024416 chr22:24240387 NA -0.36 -6.02 -0.31 4.71e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg05564831 chr3:52568323 NT5DC2 0.35 6.44 0.33 4.05e-10 Electroencephalogram traits; LUSC cis rs2387326 0.717 rs12254442 chr10:129945793 C/T cg16087940 chr10:129947807 NA -0.4 -6.12 -0.32 2.59e-9 Select biomarker traits; LUSC cis rs6942756 0.737 rs61570833 chr7:128933492 C/A cg02491457 chr7:128862824 NA -0.48 -6.64 -0.34 1.28e-10 White matter hyperintensity burden; LUSC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg25258033 chr6:167368657 RNASET2 0.49 8.1 0.41 1.04e-14 Crohn's disease; LUSC cis rs7119167 0.901 rs7952686 chr11:73128503 C/T cg17517138 chr11:73019481 ARHGEF17 0.54 6.07 0.32 3.45e-9 Blood protein levels; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.95 0.36 1.97e-11 Platelet count; LUSC cis rs7582720 1.000 rs72934767 chr2:203766563 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.66 0.43 2.06e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg22823121 chr1:150693482 HORMAD1 -0.49 -6.82 -0.35 4.25e-11 Blood protein levels; LUSC cis rs7191439 0.790 rs2306046 chr16:88781419 A/G cg02389323 chr16:88786976 FAM38A 1.11 11.41 0.53 1.14e-25 Plateletcrit; LUSC cis rs11971779 0.648 rs6467849 chr7:139080512 C/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.513 rs1608908 chr12:33895389 C/A cg26384229 chr12:38710491 ALG10B 0.59 9.42 0.46 7.54e-19 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06573718 chr12:99038766 APAF1;IKBIP -0.46 -6.98 -0.36 1.56e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11924390 0.800 rs1648698 chr3:186449582 G/C cg12454167 chr3:186435060 KNG1 0.28 7.6 0.38 2.98e-13 Adiponectin levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10954665 chr17:36453009 MRPL45 -0.46 -6.84 -0.35 3.76e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.79e-8 Depression; LUSC cis rs360798 0.532 rs2136737 chr2:62969310 G/C cg17519650 chr2:63277830 OTX1 -0.5 -7.02 -0.36 1.21e-11 Coronary artery disease; LUSC cis rs11250098 0.567 rs4326350 chr8:10763655 C/G cg27411982 chr8:10470053 RP1L1 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3916 1.000 rs34708625 chr12:121180019 T/C cg27246729 chr12:121163418 ACADS 0.46 6.59 0.34 1.7e-10 Urinary metabolites (H-NMR features); LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg18538332 chr22:24372958 LOC391322 0.46 8.13 0.41 8.45e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.47 -0.33 3.41e-10 High light scatter reticulocyte count; LUSC cis rs2074585 0.806 rs2657949 chr15:90950790 G/A cg10434728 chr15:90938212 IQGAP1 0.43 8.72 0.43 1.35e-16 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs8077889 0.917 rs58080788 chr17:41902909 A/G cg26893861 chr17:41843967 DUSP3 0.87 13.5 0.59 1.99e-33 Triglycerides; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg16606324 chr3:10149918 C3orf24 0.62 9.06 0.44 1.15e-17 Alzheimer's disease; LUSC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.51 -0.38 5.35e-13 Aortic root size; LUSC trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg06636001 chr8:8085503 FLJ10661 -0.47 -7.16 -0.36 5.25e-12 Neuroticism; LUSC cis rs7572644 0.699 rs2337373 chr2:28092922 T/C cg27432699 chr2:27873401 GPN1 -0.51 -6.97 -0.36 1.75e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs57994353 0.568 rs10747044 chr9:139319129 G/T cg14019695 chr9:139328340 INPP5E 0.36 5.94 0.31 7.22e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; LUSC cis rs2639990 1.000 rs2639990 chr18:72915551 T/C cg11568697 chr18:72916393 ZADH2 0.62 6.84 0.35 3.9e-11 Vascular endothelial growth factor levels; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg03354898 chr7:1950403 MAD1L1 -0.44 -8.93 -0.44 3.01e-17 Bipolar disorder and schizophrenia; LUSC cis rs12912251 0.948 rs34141940 chr15:38989657 G/A cg01338139 chr15:38987640 C15orf53 -0.51 -7.11 -0.36 7.04e-12 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs7089973 0.604 rs11196939 chr10:116593175 A/G cg23260525 chr10:116636907 FAM160B1 -0.46 -9.65 -0.47 1.38e-19 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6580649 0.941 rs72644844 chr12:48465425 A/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs6429082 0.608 rs4659836 chr1:235564412 G/A cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.87 -0.35 3.14e-11 Adiposity; LUSC cis rs9300255 0.602 rs2510885 chr12:123614813 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.02 -0.31 4.6e-9 Neutrophil percentage of white cells; LUSC cis rs9815354 1.000 rs1612124 chr3:41967893 C/A cg03022575 chr3:42003672 ULK4 -0.58 -6.4 -0.33 5.41e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs427941 0.703 rs201443 chr7:101737688 A/T cg06246474 chr7:101738831 CUX1 0.41 6.71 0.34 8.21e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg20295408 chr7:1910781 MAD1L1 -0.5 -7.15 -0.36 5.68e-12 Bipolar disorder and schizophrenia; LUSC cis rs2762353 0.904 rs13197514 chr6:25785991 C/T cg03264133 chr6:25882463 NA 0.42 7.23 0.37 3.36e-12 Blood metabolite levels; LUSC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg06022373 chr22:39101656 GTPBP1 0.81 12.63 0.57 3.64e-30 Menopause (age at onset); LUSC cis rs308403 0.600 rs376131 chr4:123629225 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.77 10.15 0.49 2.75e-21 Blood protein levels; LUSC cis rs6785206 0.892 rs6793907 chr3:128391626 A/G cg16766828 chr3:128327626 NA 0.64 7.44 0.38 8.86e-13 Lymphocyte percentage of white cells; LUSC trans rs10098647 0.632 rs11778794 chr8:61108773 A/C cg09970348 chr3:183978600 ECE2;CAMK2N2 0.46 6.15 0.32 2.26e-9 Obesity-related traits; LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs9733 0.681 rs7412746 chr1:150860471 C/T cg04414720 chr1:150670196 GOLPH3L -0.45 -6.97 -0.36 1.68e-11 Tonsillectomy; LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg14004847 chr7:1930337 MAD1L1 -0.45 -6.5 -0.34 2.95e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC trans rs9467711 0.790 rs13195401 chr6:26463574 G/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.36 -0.33 6.82e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs66887589 0.616 rs11098498 chr4:120187119 T/C cg24375607 chr4:120327624 NA 0.49 7.53 0.38 4.7e-13 Diastolic blood pressure; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06956805 chr11:485055 PTDSS2 -0.81 -6.62 -0.34 1.43e-10 Cognitive performance; LUSC cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.89 0.31 9.61e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10710896 chr2:202645397 ALS2 -0.44 -6.41 -0.33 4.92e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg09479241 chr17:27052676 TLCD1 0.43 5.75 0.3 2.06e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs11583043 0.918 rs6675403 chr1:101418569 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.85 0.35 3.59e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.74e-12 Resting heart rate; LUSC trans rs1728785 0.688 rs7203363 chr16:68587692 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.29 0.41 2.71e-15 Ulcerative colitis; LUSC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg16850897 chr7:100343110 ZAN -0.6 -8.3 -0.41 2.61e-15 Other erythrocyte phenotypes; LUSC cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.49 0.5 1.89e-22 Schizophrenia; LUSC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg14668632 chr7:2872130 GNA12 -0.42 -6.14 -0.32 2.37e-9 Height; LUSC cis rs9467773 1.000 rs1078679 chr6:26568741 C/T cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.59 -0.34 1.71e-10 Schizophrenia; LUSC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg00339695 chr16:24857497 SLC5A11 0.61 9.26 0.45 2.53e-18 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg11764359 chr7:65958608 NA -0.68 -10.39 -0.49 4.22e-22 Aortic root size; LUSC cis rs10992471 0.603 rs12336415 chr9:95195458 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -7.95 -0.4 2.84e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg09085632 chr11:111637200 PPP2R1B 1.11 16.05 0.66 2.18e-43 Primary sclerosing cholangitis; LUSC cis rs7799006 0.606 rs12535174 chr7:2310974 C/T cg12823233 chr7:2316876 SNX8 -0.45 -7.58 -0.38 3.52e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7412746 0.611 rs2228099 chr1:150808889 C/G cg22823121 chr1:150693482 HORMAD1 0.52 8.05 0.4 1.5e-14 Melanoma; LUSC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg16423285 chr20:60520624 NA -0.46 -5.75 -0.3 1.98e-8 Body mass index; LUSC cis rs4834770 0.765 rs1511016 chr4:120170355 A/T cg24375607 chr4:120327624 NA 0.4 5.69 0.3 2.84e-8 Blood protein levels; LUSC cis rs3749237 1.000 rs11710675 chr3:49751900 C/A cg03060546 chr3:49711283 APEH 0.55 7.7 0.39 1.53e-13 Resting heart rate; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24972377 chr12:122326574 PSMD9 -0.52 -6.9 -0.35 2.6e-11 Bipolar disorder and schizophrenia; LUSC cis rs10761482 0.861 rs10733763 chr10:62109280 T/C cg18175470 chr10:62150864 ANK3 -0.5 -7.05 -0.36 1.05e-11 Schizophrenia; LUSC cis rs1371867 0.846 rs2047249 chr8:101234126 A/G cg06636551 chr8:101224915 SPAG1 0.41 7.22 0.37 3.51e-12 Atrioventricular conduction; LUSC cis rs367943 0.712 rs6594709 chr5:112700714 T/C cg12552261 chr5:112820674 MCC 0.39 6.5 0.34 2.96e-10 Type 2 diabetes; LUSC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg15352829 chr14:105391018 PLD4 -0.4 -8.41 -0.42 1.18e-15 Rheumatoid arthritis; LUSC cis rs9341808 0.538 rs623048 chr6:80981916 C/T cg08355045 chr6:80787529 NA -0.39 -6.68 -0.34 9.8e-11 Sitting height ratio; LUSC cis rs7215564 0.908 rs34199628 chr17:78661675 A/G cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02034563 chr2:179060011 OSBPL6 0.44 6.03 0.31 4.31e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg09267113 chr7:98030324 BAIAP2L1 0.38 5.78 0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs12618769 0.597 rs2278212 chr2:99136266 T/C cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC trans rs6076960 0.622 rs6054063 chr20:6262992 C/A cg21095983 chr6:86352623 SYNCRIP 0.52 8.28 0.41 2.98e-15 Smooth-surface caries; LUSC trans rs1814175 0.754 rs10219245 chr11:49645052 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.19 -0.8 2.06e-75 Height; LUSC cis rs6695223 1.000 rs4907130 chr1:85536879 T/C cg22153463 chr1:85462885 MCOLN2 -0.59 -5.65 -0.3 3.46e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg20243544 chr17:37824526 PNMT -0.47 -5.9 -0.31 9.11e-9 Glomerular filtration rate (creatinine); LUSC trans rs1417205 1.000 rs9316278 chr13:47841469 A/G cg21511415 chr3:126034448 NA -0.49 -6.18 -0.32 1.83e-9 Cannabis use (initiation); LUSC cis rs7799006 0.895 rs3757437 chr7:2271980 C/T cg02951883 chr7:2050386 MAD1L1 -0.37 -6.21 -0.32 1.58e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg12419862 chr22:24373484 LOC391322 0.86 14.03 0.61 1.75e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1997103 1.000 rs6954474 chr7:55404847 A/G cg17469321 chr7:55412551 NA 0.66 10.46 0.5 2.51e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs739401 0.527 rs418832 chr11:3072236 C/T cg05729581 chr11:3078854 CARS -0.53 -8.13 -0.41 8.39e-15 Longevity; LUSC trans rs7822058 0.722 rs7460309 chr8:53693490 A/G cg16864198 chr12:26340863 NA 0.45 6.15 0.32 2.22e-9 Obesity-related traits; LUSC cis rs3744061 0.569 rs2240769 chr17:74718155 C/T cg02128979 chr17:74682217 MXRA7 0.43 6.52 0.34 2.63e-10 Retinal arteriolar caliber; LUSC cis rs12711979 0.765 rs10208316 chr2:3827630 T/C cg17052675 chr2:3827356 NA -0.59 -11.22 -0.52 5.44e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg08975724 chr8:8085496 FLJ10661 -0.53 -7.79 -0.39 8.65e-14 Mood instability; LUSC cis rs1971762 0.563 rs3897117 chr12:54077407 T/G cg23533419 chr12:54090519 NA -0.37 -6.02 -0.31 4.6e-9 Height; LUSC cis rs546131 0.928 rs499183 chr11:34836678 A/G cg06937548 chr11:34938143 PDHX;APIP 0.49 6.91 0.35 2.43e-11 Lung disease severity in cystic fibrosis; LUSC cis rs6977660 0.660 rs12531296 chr7:19816450 A/C cg07541023 chr7:19748670 TWISTNB 0.63 6.84 0.35 3.87e-11 Thyroid stimulating hormone; LUSC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg01579765 chr21:45077557 HSF2BP 0.51 10.86 0.51 9.57e-24 Mean corpuscular volume; LUSC cis rs2549003 0.811 rs10072700 chr5:131816903 A/C cg21138405 chr5:131827807 IRF1 0.47 7.5 0.38 5.97e-13 Asthma (sex interaction); LUSC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.812 rs73073326 chr3:41834195 G/T cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg22920501 chr2:26401640 FAM59B 0.82 11.99 0.55 8.49e-28 Gut microbiome composition (summer); LUSC cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs9467773 1.000 rs6456733 chr6:26566804 C/T cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg12963246 chr6:28129442 ZNF389 0.51 6.17 0.32 1.99e-9 Depression; LUSC trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg15704280 chr7:45808275 SEPT13 -0.6 -7.38 -0.37 1.29e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs892961 0.867 rs6501955 chr17:75414443 A/G cg05865280 chr17:75406074 SEPT9 0.46 9.67 0.47 1.13e-19 Airflow obstruction; LUSC cis rs4363385 0.765 rs11205165 chr1:152986928 G/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.37 -0.37 1.33e-12 Inflammatory skin disease; LUSC cis rs55665837 1.000 rs7121171 chr11:14446420 A/G cg19336497 chr11:14380999 RRAS2 -0.36 -7.21 -0.37 3.69e-12 Vitamin D levels; LUSC cis rs8062405 0.755 rs7186573 chr16:28587389 T/C cg16576597 chr16:28551801 NUPR1 0.31 6.3 0.33 9.58e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7103648 1.000 rs7947450 chr11:47429904 G/A cg20307385 chr11:47447363 PSMC3 0.99 19.5 0.73 4.42e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs950169 0.922 rs12912934 chr15:85114447 C/T cg17173187 chr15:85201210 NMB 0.35 6.29 0.33 1e-9 Schizophrenia; LUSC cis rs6489785 0.509 rs4767937 chr12:121223244 G/C cg02419362 chr12:121203948 SPPL3 0.46 8.62 0.43 2.8e-16 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.47 0.38 7.06e-13 Hemoglobin concentration; LUSC cis rs8141529 0.764 rs5762854 chr22:29246278 T/C cg15103426 chr22:29168792 CCDC117 0.58 7.95 0.4 2.83e-14 Lymphocyte counts; LUSC trans rs6445975 0.666 rs4390943 chr3:58376639 A/C cg18950693 chr14:70346909 SMOC1 0.38 6.05 0.31 3.97e-9 Systemic lupus erythematosus; LUSC cis rs4319547 0.741 rs4758663 chr12:122939483 A/G cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.17 -0.41 6.41e-15 Body mass index; LUSC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg11871910 chr12:69753446 YEATS4 0.92 17.3 0.69 2.46e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.61 0.65 1.27e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs911555 0.504 rs4906340 chr14:104076645 G/A cg24130564 chr14:104152367 KLC1 0.68 10.63 0.5 6.39e-23 Intelligence (multi-trait analysis); LUSC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg20684491 chr1:25596433 NA -0.38 -5.92 -0.31 7.88e-9 Erythrocyte sedimentation rate; LUSC cis rs2439831 1.000 rs689781 chr15:43792097 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg21951975 chr1:209979733 IRF6 0.56 7.34 0.37 1.63e-12 Cleft lip with or without cleft palate; LUSC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg07636037 chr3:49044803 WDR6 -0.94 -15.12 -0.64 1e-39 Menarche (age at onset); LUSC cis rs7917772 0.582 rs4917975 chr10:104358407 C/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.26e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg21280719 chr6:42927975 GNMT -0.3 -7.63 -0.39 2.56e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg17143192 chr8:8559678 CLDN23 -0.37 -5.74 -0.3 2.11e-8 Mood instability; LUSC trans rs4948088 1.000 rs2329568 chr7:51018103 C/G cg26816907 chr1:197890812 LHX9 0.56 6.21 0.32 1.62e-9 Type 1 diabetes; LUSC cis rs941898 0.957 rs7159195 chr14:100583330 G/A cg26002632 chr14:100625216 DEGS2 -0.31 -5.69 -0.3 2.71e-8 White matter hyperintensity burden; LUSC cis rs6076065 0.723 rs4813495 chr20:23391617 A/G cg11657817 chr20:23433608 CST11 0.42 8.01 0.4 1.94e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs453301 0.506 rs686189 chr8:8623637 A/G cg08975724 chr8:8085496 FLJ10661 -0.49 -6.9 -0.35 2.61e-11 Joint mobility (Beighton score); LUSC cis rs2115630 0.967 rs11073702 chr15:85310071 G/A cg09876464 chr15:85330779 ZNF592 0.36 6.67 0.34 1.05e-10 P wave terminal force; LUSC cis rs7107174 0.901 rs4945275 chr11:78119822 G/A cg02023728 chr11:77925099 USP35 0.41 6.3 0.33 9.43e-10 Testicular germ cell tumor; LUSC cis rs3087591 1.000 rs6505235 chr17:29688603 C/A cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.78 -0.39 8.96e-14 Hip circumference; LUSC cis rs11098499 0.779 rs10016060 chr4:120298412 A/G cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs7953249 0.656 rs6489786 chr12:121397875 A/G cg25281562 chr12:121454272 C12orf43 -0.43 -5.67 -0.3 3.04e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs8060686 0.623 rs7204208 chr16:68069416 A/G cg05110241 chr16:68378359 PRMT7 -0.44 -5.77 -0.3 1.77e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs983392 0.678 rs7108663 chr11:60028142 C/T cg20284999 chr11:59952153 MS4A6A 0.38 6.44 0.33 4.09e-10 Alzheimer's disease (late onset); LUSC cis rs9788682 0.694 rs10851906 chr15:78774676 A/G cg06917634 chr15:78832804 PSMA4 -0.48 -5.94 -0.31 7.15e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg04414720 chr1:150670196 GOLPH3L -0.48 -7.16 -0.36 5.06e-12 Blood protein levels; LUSC cis rs4253772 1.000 rs11705483 chr22:46630544 C/A cg09491104 chr22:46646882 C22orf40 -0.62 -6.55 -0.34 2.16e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg20203395 chr5:56204925 C5orf35 -0.45 -6.67 -0.34 1.03e-10 Breast cancer;Breast cancer (early onset); LUSC cis rs4253772 0.744 rs9627278 chr22:46643432 C/G cg09491104 chr22:46646882 C22orf40 -0.58 -7.98 -0.4 2.34e-14 LDL cholesterol;Cholesterol, total; LUSC cis rs9513627 0.749 rs73556149 chr13:100117012 G/A cg25919922 chr13:100150906 NA -0.74 -6.22 -0.32 1.52e-9 Obesity-related traits; LUSC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg26924012 chr15:45694286 SPATA5L1 -1.06 -17.07 -0.68 2.15e-47 Homoarginine levels; LUSC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg25072359 chr17:41440525 NA 0.66 9.25 0.45 2.8e-18 Menopause (age at onset); LUSC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg07636037 chr3:49044803 WDR6 1.05 18.88 0.72 1.28e-54 Parkinson's disease; LUSC cis rs1506636 1.000 rs2215554 chr7:123347063 A/C cg03229431 chr7:123269106 ASB15 -0.63 -10.1 -0.48 4.09e-21 Plateletcrit;Platelet count; LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.16 0.32 2.13e-9 Bipolar disorder; LUSC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg03351412 chr1:154909251 PMVK 0.53 8.19 0.41 5.74e-15 Prostate cancer; LUSC cis rs4494114 0.967 rs9438980 chr1:39355371 A/G cg25970120 chr1:39325951 RRAGC -0.38 -5.96 -0.31 6.24e-9 Blood protein levels; LUSC cis rs7666738 0.546 rs7699578 chr4:98838893 T/C cg03676636 chr4:99064102 C4orf37 0.33 6.07 0.32 3.55e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6733011 0.578 rs11893888 chr2:99495239 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.44 -6.19 -0.32 1.73e-9 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08470185 chr1:1334798 CCNL2;LOC148413 0.42 6.31 0.33 8.88e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg00071950 chr4:10020882 SLC2A9 -0.62 -10.15 -0.49 2.9e-21 Bone mineral density; LUSC cis rs4494114 1.000 rs3790442 chr1:39357646 C/A cg25970120 chr1:39325951 RRAGC -0.4 -6.21 -0.32 1.58e-9 Blood protein levels; LUSC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg13393036 chr8:95962371 TP53INP1 -0.5 -10.92 -0.51 6.08e-24 Type 2 diabetes; LUSC cis rs1577917 0.798 rs7772384 chr6:86639680 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs656319 0.674 rs1484639 chr8:9983224 T/G cg06636001 chr8:8085503 FLJ10661 0.49 7.11 0.36 7.17e-12 Myopia (pathological); LUSC cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg02175503 chr12:58329896 NA 0.61 10.06 0.48 5.74e-21 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.13e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs4474465 0.703 rs10899547 chr11:78254720 C/T cg27205649 chr11:78285834 NARS2 0.53 6.36 0.33 6.57e-10 Alzheimer's disease (survival time); LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg05165339 chr4:1420672 NA -0.3 -6.62 -0.34 1.42e-10 Longevity; LUSC trans rs2797160 0.651 rs6569436 chr6:126032104 A/G cg05039488 chr6:79577232 IRAK1BP1 0.63 9.79 0.47 4.6e-20 Endometrial cancer; LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg01802117 chr1:53393560 SCP2 0.37 6.11 0.32 2.83e-9 Monocyte count; LUSC cis rs6840360 0.571 rs4696276 chr4:152532682 G/A cg22705602 chr4:152727874 NA -0.32 -6.53 -0.34 2.44e-10 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg21573476 chr21:45109991 RRP1B -0.36 -5.88 -0.31 1.02e-8 Mean corpuscular volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23486179 chr3:49466665 NICN1 -0.51 -6.34 -0.33 7.64e-10 Bipolar disorder and schizophrenia; LUSC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg17328964 chr8:145687451 CYHR1 -0.4 -6.13 -0.32 2.48e-9 Age at first birth; LUSC cis rs61990749 0.597 rs6574402 chr14:78267950 C/A cg02301378 chr14:78227641 SNW1;C14orf178 0.61 6.34 0.33 7.34e-10 Fibroblast growth factor basic levels; LUSC cis rs1775715 0.707 rs2808094 chr10:32133756 T/C cg04359828 chr10:32216031 ARHGAP12 0.41 7.07 0.36 9.07e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1030877 0.557 rs2576752 chr2:105978761 A/G cg02079111 chr2:105885981 TGFBRAP1 0.53 9.05 0.44 1.23e-17 Obesity-related traits; LUSC cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg10207240 chr12:122356781 WDR66 0.46 6.46 0.33 3.61e-10 Mean corpuscular volume; LUSC cis rs1014246 0.848 rs58568639 chr10:118456886 C/G cg14919929 chr10:118506882 NA 0.47 7.29 0.37 2.31e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs7937682 0.889 rs3017767 chr11:111508098 A/G cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs2236918 0.901 rs1776135 chr1:242025530 A/G cg17736920 chr1:242011382 EXO1 0.44 6.86 0.35 3.3e-11 Menopause (age at onset); LUSC cis rs4499344 0.730 rs259286 chr19:33164759 C/T cg22980127 chr19:33182716 NUDT19 -0.44 -6.64 -0.34 1.3100000000000001e-10 Mean platelet volume; LUSC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg10128416 chr1:75198403 TYW3;CRYZ 0.48 7.55 0.38 4.28e-13 Resistin levels; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg26304593 chr6:42947056 PEX6 -0.53 -8.48 -0.42 7.42e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg12463550 chr7:65579703 CRCP 0.42 6.0 0.31 5.11e-9 Calcium levels; LUSC trans rs12310956 0.510 rs10844694 chr12:33865682 A/C cg26384229 chr12:38710491 ALG10B 0.57 8.84 0.44 5.71e-17 Morning vs. evening chronotype; LUSC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg05623727 chr3:50126028 RBM5 0.31 5.81 0.3 1.43e-8 Intelligence (multi-trait analysis); LUSC cis rs9399401 0.710 rs12197866 chr6:142706063 C/T cg04461802 chr6:142623433 GPR126 0.47 5.87 0.31 1.06e-8 Chronic obstructive pulmonary disease; LUSC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg12927641 chr6:109611667 NA -0.43 -7.5 -0.38 5.64e-13 Reticulocyte fraction of red cells; LUSC cis rs7215564 0.730 rs4889877 chr17:78662459 A/C cg23238734 chr17:78661607 RPTOR 0.45 5.81 0.3 1.49e-8 Myopia (pathological); LUSC cis rs6456156 0.586 rs12529876 chr6:167461501 G/A cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg07092213 chr7:1199455 ZFAND2A 0.42 6.49 0.33 3.11e-10 Longevity;Endometriosis; LUSC cis rs56283067 0.886 rs56110323 chr6:44679934 G/A cg20913747 chr6:44695427 NA -0.47 -7.83 -0.39 6.54e-14 Total body bone mineral density; LUSC trans rs800082 0.668 rs9876975 chr3:144292255 G/A cg24215973 chr2:240111563 HDAC4 -0.62 -9.89 -0.48 2.08e-20 Smoking behavior; LUSC cis rs4290604 0.748 rs10754942 chr2:238075187 T/C cg23555395 chr2:238036564 NA -0.47 -6.41 -0.33 4.85e-10 Asthma; LUSC cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg13256891 chr4:100009986 ADH5 -0.44 -6.11 -0.32 2.83e-9 Alcohol dependence; LUSC cis rs9905704 0.587 rs2003537 chr17:56611871 C/G cg19466818 chr17:56409534 MIR142 0.35 6.53 0.34 2.48e-10 Testicular germ cell tumor; LUSC cis rs208520 0.661 rs207079 chr6:66770462 C/T cg07460842 chr6:66804631 NA -1.11 -17.7 -0.7 6.23e-50 Exhaled nitric oxide output; LUSC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg23758822 chr17:41437982 NA 1.0 19.79 0.73 3.27e-58 Menopause (age at onset); LUSC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg27535305 chr1:53392650 SCP2 0.33 6.01 0.31 4.85e-9 Monocyte count; LUSC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg06481639 chr22:41940642 POLR3H -0.49 -5.69 -0.3 2.79e-8 Vitiligo; LUSC cis rs9790314 0.543 rs1349352 chr3:161118486 C/T cg03342759 chr3:160939853 NMD3 -0.44 -6.83 -0.35 4.12e-11 Morning vs. evening chronotype; LUSC cis rs3806843 0.900 rs2563254 chr5:140142701 T/C cg19875535 chr5:140030758 IK -0.48 -7.72 -0.39 1.34e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs2559856 1.000 rs2695288 chr12:102088112 T/C cg12924262 chr12:102091054 CHPT1 0.45 6.26 0.32 1.2e-9 Blood protein levels; LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg12639453 chr1:2035780 PRKCZ 0.32 6.87 0.35 3.18e-11 Height; LUSC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg12311346 chr5:56204834 C5orf35 -0.97 -14.0 -0.61 2.41e-35 Initial pursuit acceleration; LUSC cis rs1348850 0.874 rs13013752 chr2:178456862 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.29 0.33 9.72e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.54e-11 Extrinsic epigenetic age acceleration; LUSC cis rs12618769 0.597 rs3769737 chr2:99088873 C/G cg10123293 chr2:99228465 UNC50 -0.46 -7.7 -0.39 1.5700000000000001e-13 Bipolar disorder; LUSC trans rs12145833 0.596 rs61833913 chr1:243440028 C/G cg01826367 chr1:224180288 NA 0.63 5.95 0.31 6.62e-9 Obesity (early onset extreme); LUSC cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg25173405 chr17:45401733 C17orf57 -0.37 -5.73 -0.3 2.2e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2573652 0.722 rs12898366 chr15:100543067 C/T cg00587665 chr15:100533223 ADAMTS17 -0.38 -6.88 -0.35 3.01e-11 Height; LUSC cis rs7246967 0.673 rs597906 chr19:22868205 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg12573674 chr2:1569213 NA -0.53 -5.72 -0.3 2.41e-8 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs1981331 1.000 rs118078026 chr21:48012129 T/C cg23283320 chr21:48055893 PRMT2 1.12 8.14 0.41 7.72e-15 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg25319279 chr11:5960081 NA -0.4 -5.79 -0.3 1.63e-8 DNA methylation (variation); LUSC cis rs4751006 0.543 rs17692028 chr10:128783983 C/T cg05702161 chr10:128779687 DOCK1 -0.77 -6.22 -0.32 1.51e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6752107 1.000 rs2289474 chr2:234181848 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.78 0.54 4.92e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs4077515 0.870 rs10781510 chr9:139279173 G/A cg14169450 chr9:139327907 INPP5E 0.41 6.98 0.36 1.57e-11 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs11105298 0.891 rs11105312 chr12:89920733 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.28 -0.37 2.35e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg14552801 chr7:65878734 NA -0.44 -6.19 -0.32 1.75e-9 Aortic root size; LUSC cis rs11098499 0.691 rs10010355 chr4:120261043 A/G cg09307838 chr4:120376055 NA 0.64 9.79 0.47 4.53e-20 Corneal astigmatism; LUSC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg16624210 chr5:671434 TPPP 0.5 6.38 0.33 6.07e-10 Obesity-related traits; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg16983211 chr12:54427636 HOXC4;HOXC5 0.46 6.33 0.33 8.06e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg04455712 chr21:45112962 RRP1B 0.45 8.87 0.44 4.61e-17 Mean corpuscular volume; LUSC cis rs7264396 0.790 rs1040695 chr20:34244829 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.85 -0.47 2.92e-20 Total cholesterol levels; LUSC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg24399712 chr22:39784796 NA -0.62 -11.12 -0.52 1.19e-24 Intelligence (multi-trait analysis); LUSC cis rs1348850 0.632 rs12467363 chr2:178502512 C/T cg22681709 chr2:178499509 PDE11A -0.6 -12.05 -0.55 5.29e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9640161 0.636 rs3735171 chr7:150033882 A/G cg10018233 chr7:150070692 REPIN1 0.39 6.79 0.35 5.11e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs11822910 1.000 rs2439448 chr11:57199211 T/C cg00522883 chr11:57194120 SLC43A3 0.42 6.62 0.34 1.45e-10 Platelet distribution width; LUSC cis rs2439831 0.702 rs8033995 chr15:44013509 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.04 0.36 1.13e-11 Lung cancer in ever smokers; LUSC cis rs2386661 0.547 rs11259540 chr10:5646706 A/T cg17085576 chr10:5658249 NA -0.43 -6.37 -0.33 6.09e-10 Breast cancer; LUSC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg17211192 chr8:82754475 SNX16 0.81 11.11 0.52 1.32e-24 Diastolic blood pressure; LUSC cis rs868036 1.000 rs1026735 chr15:68101700 A/G cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs58785573 0.504 rs11947292 chr4:38634749 A/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.59 8.95 0.44 2.54e-17 Lymphocyte percentage of white cells; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg01802117 chr1:53393560 SCP2 -0.39 -6.5 -0.33 2.99e-10 Monocyte count; LUSC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg06656553 chr16:89960601 TCF25 -0.64 -5.66 -0.3 3.2e-8 Skin colour saturation; LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.2 0.32 1.7e-9 Menopause (age at onset); LUSC cis rs55986470 0.646 rs112559043 chr2:239446187 A/G cg18131467 chr2:239335373 ASB1 -0.73 -5.79 -0.3 1.62e-8 Chronotype; LUSC cis rs365132 0.875 rs2940521 chr5:176339209 A/C cg25401027 chr5:176370377 UIMC1 0.35 5.74 0.3 2.11e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs11122272 0.637 rs2808593 chr1:231524228 G/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg02423579 chr7:2872169 GNA12 -0.5 -7.05 -0.36 1.03e-11 Height; LUSC cis rs478304 0.754 rs2004649 chr11:65380916 G/A cg05805236 chr11:65401703 PCNXL3 -0.5 -8.13 -0.41 8.52e-15 Acne (severe); LUSC cis rs6076065 0.723 rs743022 chr20:23401129 G/C cg11657817 chr20:23433608 CST11 0.42 7.5 0.38 5.87e-13 Facial morphology (factor 15, philtrum width); LUSC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg11502198 chr6:26597334 ABT1 0.72 12.03 0.55 6.32e-28 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05972308 chr16:31476161 ARMC5 -0.73 -6.12 -0.32 2.66e-9 Cognitive performance; LUSC cis rs7582180 0.629 rs6716636 chr2:100940067 C/G cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.89e-8 Intelligence (multi-trait analysis); LUSC cis rs2692947 1.000 rs2692947 chr2:96674116 T/C cg23100626 chr2:96804247 ASTL 0.23 5.67 0.3 3.14e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs73198271 0.740 rs10092720 chr8:8649117 A/C cg01851573 chr8:8652454 MFHAS1 0.53 8.71 0.43 1.48e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs243505 0.624 rs6975291 chr7:148548393 C/G cg09806900 chr7:148480153 CUL1 0.48 6.39 0.33 5.5e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1371867 0.875 rs1788173 chr8:101330939 A/G cg06002616 chr8:101225028 SPAG1 0.39 6.65 0.34 1.23e-10 Atrioventricular conduction; LUSC cis rs73206853 0.841 rs57821814 chr12:110829254 A/C cg12870014 chr12:110450643 ANKRD13A 0.67 6.46 0.33 3.72e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg09436375 chr6:42928200 GNMT -0.3 -7.03 -0.36 1.18e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.27 -0.37 2.58e-12 Monocyte count; LUSC cis rs9814567 1.000 rs4498009 chr3:134198008 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.03e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6565189 1.000 rs6565189 chr16:30507265 A/C cg17640201 chr16:30407289 ZNF48 0.45 6.08 0.32 3.2e-9 Tonsillectomy; LUSC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg09509183 chr1:209979624 IRF6 0.43 5.73 0.3 2.25e-8 Cleft lip with or without cleft palate; LUSC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg04352962 chr1:209979756 IRF6 0.58 6.66 0.34 1.1e-10 Cleft lip with or without cleft palate; LUSC cis rs7824557 0.527 rs2572448 chr8:11239352 G/A cg21775007 chr8:11205619 TDH -0.67 -10.48 -0.5 2.06e-22 Retinal vascular caliber; LUSC cis rs710216 0.957 rs841570 chr1:43435571 C/G cg22176566 chr1:43424700 SLC2A1 0.46 5.89 0.31 9.22e-9 Red cell distribution width; LUSC trans rs61931739 0.500 rs11053218 chr12:34474792 A/C cg13010199 chr12:38710504 ALG10B -0.63 -9.72 -0.47 7.93e-20 Morning vs. evening chronotype; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg00945038 chr17:61921165 SMARCD2 0.51 8.63 0.43 2.48e-16 Prudent dietary pattern; LUSC cis rs2651899 0.902 rs1798246 chr1:3080855 A/C cg22674798 chr1:3096360 PRDM16 0.28 6.46 0.33 3.72e-10 Migraine; LUSC cis rs9326248 0.768 rs4936366 chr11:117026885 G/A cg26566898 chr11:117069891 TAGLN 0.38 6.06 0.31 3.6e-9 Blood protein levels; LUSC cis rs4561483 0.556 rs11570136 chr16:12058832 T/A cg08843971 chr16:11963173 GSPT1 -0.42 -6.02 -0.31 4.68e-9 Testicular germ cell tumor; LUSC cis rs9359856 0.564 rs11961752 chr6:90481896 T/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.51 -0.42 5.78e-16 Bipolar disorder; LUSC cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg00033643 chr7:134001901 SLC35B4 0.43 6.3 0.33 9.64e-10 Mean platelet volume; LUSC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg00864171 chr11:67383662 NA 0.35 6.32 0.33 8.55e-10 Mean corpuscular volume; LUSC cis rs10782582 0.632 rs11810154 chr1:76239973 C/G cg10523679 chr1:76189770 ACADM -0.43 -6.21 -0.32 1.53e-9 Daytime sleep phenotypes; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg27284194 chr4:1044797 NA 0.35 5.83 0.3 1.32e-8 Obesity-related traits; LUSC cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14008834 chr4:24472254 NA 0.36 5.99 0.31 5.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg16606324 chr3:10149918 C3orf24 0.44 6.78 0.35 5.34e-11 Alzheimer's disease; LUSC cis rs11098499 0.955 rs11931312 chr4:120159023 T/C cg24375607 chr4:120327624 NA 0.76 11.54 0.53 3.82e-26 Corneal astigmatism; LUSC cis rs8038465 0.592 rs1542579 chr15:73935897 A/G cg15420318 chr15:73925796 NPTN 0.58 10.11 0.48 3.77e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg13010199 chr12:38710504 ALG10B 0.68 11.42 0.53 1.02e-25 Heart rate; LUSC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.59 -0.38 3.19e-13 Developmental language disorder (linguistic errors); LUSC cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg24812749 chr6:127587940 RNF146 0.92 13.97 0.61 3.03e-35 Breast cancer; LUSC cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg05283184 chr6:79620031 NA -0.57 -12.14 -0.55 2.5e-28 Intelligence (multi-trait analysis); LUSC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg14784868 chr12:69753453 YEATS4 0.61 8.85 0.44 5.16e-17 Response to diuretic therapy; LUSC cis rs9303401 0.573 rs67378767 chr17:57194237 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.83 12.57 0.57 6.01e-30 Cognitive test performance; LUSC cis rs10484885 0.824 rs72921954 chr6:90586656 A/G cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.31 -0.41 2.43e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg21918786 chr6:109611834 NA -0.41 -7.2 -0.37 3.92e-12 Reticulocyte fraction of red cells; LUSC cis rs3741151 0.686 rs12291233 chr11:73272946 T/G cg17517138 chr11:73019481 ARHGEF17 0.82 7.65 0.39 2.15e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg18305652 chr10:134549665 INPP5A 0.44 6.68 0.34 9.79e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.96 -12.97 -0.58 1.97e-31 Gut microbiome composition (summer); LUSC cis rs7216064 1.000 rs2128792 chr17:65857177 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.25 -0.45 2.79e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs3087591 0.708 rs12940802 chr17:29643564 C/A cg24425628 chr17:29625626 OMG;NF1 0.47 7.09 0.36 8.2e-12 Hip circumference; LUSC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.29e-12 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.65 -9.73 -0.47 7.55e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1178968 0.818 rs2108235 chr7:72783383 A/G cg25889504 chr7:72793014 NA 0.61 8.21 0.41 4.75e-15 Triglyceride levels; LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2278907 0.898 rs4073959 chr11:68481490 C/T cg10806483 chr12:102459329 NA 0.32 6.09 0.32 3.08e-9 Total body bone mineral density; LUSC cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg03146154 chr1:46216737 IPP 0.56 8.32 0.41 2.35e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg02475777 chr4:1388615 CRIPAK 0.44 6.58 0.34 1.84e-10 Obesity-related traits; LUSC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg25767906 chr1:53392781 SCP2 -0.53 -9.61 -0.47 1.84e-19 Monocyte count; LUSC cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.32 -0.41 2.25e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9611519 1.000 rs5758267 chr22:41619350 A/T cg03806693 chr22:41940476 POLR3H 0.47 6.56 0.34 2.04e-10 Neuroticism; LUSC cis rs12823128 1.000 rs12823128 chr12:26872730 C/T cg19407459 chr12:26986763 ITPR2 -0.42 -5.8 -0.3 1.55e-8 Birth weight; LUSC cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg15605315 chr1:45957053 TESK2 0.43 6.6 0.34 1.63e-10 High light scatter reticulocyte count; LUSC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg05625103 chr10:2543513 NA 0.5 7.33 0.37 1.74e-12 Age-related hearing impairment; LUSC cis rs977987 0.778 rs4887821 chr16:75398574 G/A cg04384234 chr16:75411784 CFDP1 -0.42 -6.95 -0.36 1.94e-11 Dupuytren's disease; LUSC trans rs11039798 0.844 rs6485820 chr11:48264711 A/G cg03929089 chr4:120376271 NA 0.66 6.25 0.32 1.23e-9 Axial length; LUSC trans rs61931739 0.500 rs2389269 chr12:34034179 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.36 0.42 1.74e-15 Morning vs. evening chronotype; LUSC cis rs1865760 1.000 rs2071298 chr6:25914901 G/A cg16482183 chr6:26056742 HIST1H1C 0.44 6.46 0.33 3.77e-10 Height; LUSC cis rs7246967 0.611 rs16999598 chr19:22943125 A/G cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs4906332 0.782 rs2236281 chr14:104000518 G/T cg04998671 chr14:104000505 TRMT61A -0.58 -7.82 -0.39 7.1e-14 Coronary artery disease; LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs11122272 0.735 rs11122280 chr1:231519816 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.85 0.47 2.87e-20 Hemoglobin concentration; LUSC cis rs6005807 0.719 rs12166245 chr22:28999890 C/T cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg19626725 chr5:178986131 RUFY1 0.52 9.06 0.44 1.13e-17 Lung cancer; LUSC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg01616529 chr11:638424 DRD4 -0.34 -5.66 -0.3 3.33e-8 Systemic lupus erythematosus; LUSC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg02423579 chr7:2872169 GNA12 -0.45 -6.29 -0.33 9.8e-10 Height; LUSC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.71 10.99 0.52 3.36e-24 Monocyte percentage of white cells; LUSC cis rs2625529 0.938 rs2723343 chr15:72108269 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.25 -0.37 2.94e-12 Red blood cell count; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.42 0.46 7.67e-19 Prudent dietary pattern; LUSC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.82 12.57 0.57 6.09e-30 IgG glycosylation; LUSC trans rs6076960 0.681 rs4487157 chr20:6249581 G/A cg21095983 chr6:86352623 SYNCRIP 0.49 7.39 0.37 1.16e-12 Smooth-surface caries; LUSC cis rs9354308 0.933 rs12194424 chr6:66574007 T/C cg07460842 chr6:66804631 NA 0.47 5.83 0.3 1.33e-8 Metabolite levels; LUSC cis rs9868809 0.881 rs7631574 chr3:48663046 A/G cg00383909 chr3:49044727 WDR6 -0.87 -8.42 -0.42 1.12e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2348418 0.715 rs1581076 chr12:28723657 A/G cg13890972 chr12:28721907 NA -0.39 -6.86 -0.35 3.39e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs870825 0.616 rs4264873 chr4:185624336 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs7312933 0.558 rs1669886 chr12:42838240 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.82 -0.35 4.27e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6601450 0.540 rs7824231 chr8:10273958 G/A cg21775007 chr8:11205619 TDH -0.45 -6.28 -0.32 1.07e-9 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs208520 1.000 rs9453671 chr6:66991208 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.8 0.54 4.39e-27 Exhaled nitric oxide output; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05779081 chr10:93683588 BTAF1 0.7 6.05 0.31 3.93e-9 Cognitive performance; LUSC cis rs11098499 0.955 rs11944880 chr4:120159334 A/G cg24375607 chr4:120327624 NA -0.75 -11.62 -0.54 1.93e-26 Corneal astigmatism; LUSC cis rs9300255 0.698 rs4759416 chr12:123746357 C/G cg00376283 chr12:123451042 ABCB9 0.66 8.34 0.42 2e-15 Neutrophil percentage of white cells; LUSC cis rs1691799 0.528 rs1472314 chr12:66788838 C/G cg16791601 chr12:66731901 HELB -0.57 -9.4 -0.46 8.98e-19 White blood cell count (basophil); LUSC cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg05855489 chr10:104503620 C10orf26 -0.6 -8.05 -0.4 1.48e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3743162 0.553 rs12915656 chr15:85415580 G/C cg12863693 chr15:85201151 NMB 0.31 5.96 0.31 6.29e-9 Alzheimer's disease (age of onset); LUSC cis rs9467773 1.000 rs10946834 chr6:26533664 G/C cg09904177 chr6:26538194 HMGN4 0.76 14.42 0.62 5.75e-37 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg20295408 chr7:1910781 MAD1L1 -0.45 -6.29 -0.33 1.01e-9 Bipolar disorder and schizophrenia; LUSC cis rs727505 1.000 rs6971909 chr7:124525517 C/T cg23710748 chr7:124431027 NA -0.4 -7.18 -0.37 4.56e-12 Lewy body disease; LUSC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg09491104 chr22:46646882 C22orf40 -0.71 -7.24 -0.37 3.2e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs3126085 0.935 rs12063165 chr1:152176357 C/T cg26876637 chr1:152193138 HRNR 0.46 6.57 0.34 1.96e-10 Atopic dermatitis; LUSC cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg01579765 chr21:45077557 HSF2BP -0.48 -10.07 -0.48 5.18e-21 Mean corpuscular volume; LUSC trans rs1146849 0.836 rs495677 chr13:72864140 A/G cg23661343 chr18:616707 CLUL1 -0.41 -5.97 -0.31 6.23e-9 Facial emotion recognition (sad faces); LUSC cis rs6598955 0.671 rs10493030 chr1:26561856 T/C cg00852783 chr1:26633632 UBXN11 -0.49 -5.8 -0.3 1.52e-8 Obesity-related traits; LUSC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg24977027 chr2:88469347 THNSL2 0.56 5.84 0.3 1.21e-8 Plasma clusterin levels; LUSC trans rs9860340 0.730 rs12108006 chr3:87636588 A/G cg03644585 chr7:884825 UNC84A 0.42 6.09 0.32 3.17e-9 Electroencephalographic traits in alcoholism; LUSC cis rs9457247 1.000 rs408040 chr6:167398903 A/T cg20406979 chr6:167373233 NA 0.26 6.13 0.32 2.5e-9 Crohn's disease; LUSC trans rs1015291 0.708 rs1565591 chr12:19997707 A/G cg01501474 chr7:55323552 NA -0.45 -5.97 -0.31 6.09e-9 Diastolic blood pressure; LUSC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11890956 chr21:40555474 PSMG1 1.03 21.12 0.76 1.7e-63 Cognitive function; LUSC cis rs11785400 0.793 rs4736367 chr8:143742477 G/A cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg24562669 chr7:97807699 LMTK2 0.36 6.32 0.33 8.56e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg23158103 chr7:148848205 ZNF398 -0.43 -6.72 -0.35 7.94e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6964587 0.839 rs6952459 chr7:91435820 T/A cg17063962 chr7:91808500 NA 0.57 8.75 0.43 1.1e-16 Breast cancer; LUSC cis rs668210 0.793 rs534201 chr11:65776728 A/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.59 7.89 0.4 4.27e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg20476274 chr7:133979776 SLC35B4 0.83 15.25 0.64 3.17e-40 Mean platelet volume; LUSC cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg09876464 chr15:85330779 ZNF592 0.36 6.57 0.34 1.94e-10 P wave terminal force; LUSC cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs12911832 0.958 rs12912003 chr15:58986001 A/T cg05156742 chr15:59063176 FAM63B 0.5 7.14 0.36 5.8e-12 Schizophrenia; LUSC cis rs1832871 0.711 rs9459877 chr6:158692331 G/A cg07165851 chr6:158734300 TULP4 0.5 7.8 0.39 7.87e-14 Height; LUSC cis rs9807841 0.617 rs2229383 chr19:10794630 G/T cg09936142 chr19:10668400 KRI1 -0.4 -6.43 -0.33 4.34e-10 Inflammatory skin disease; LUSC cis rs10751667 0.643 rs7395613 chr11:933873 C/T ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs2658782 0.547 rs4344448 chr11:93047047 T/C cg15737290 chr11:93063684 CCDC67 0.9 13.72 0.6 2.69e-34 Pulmonary function decline; LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg10729496 chr3:10149963 C3orf24 0.52 7.11 0.36 7.19e-12 Alzheimer's disease; LUSC cis rs6430585 0.528 rs115469964 chr2:136696608 A/C cg07169764 chr2:136633963 MCM6 1.15 18.77 0.72 3.45e-54 Corneal structure; LUSC cis rs7927592 0.513 rs901823 chr11:68205578 T/C cg20283391 chr11:68216788 NA -0.51 -7.34 -0.37 1.67e-12 Total body bone mineral density; LUSC cis rs72781680 0.898 rs718139 chr2:23975911 G/A cg20701182 chr2:24300061 SF3B14 0.77 7.69 0.39 1.67e-13 Lymphocyte counts; LUSC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg15445000 chr17:37608096 MED1 0.39 6.77 0.35 5.9e-11 Glomerular filtration rate (creatinine); LUSC cis rs2404602 0.692 rs55729975 chr15:76803226 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.81 -0.39 7.68e-14 Blood metabolite levels; LUSC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.73 -0.35 7.19e-11 Alzheimer's disease (late onset); LUSC cis rs7000551 0.606 rs7844699 chr8:22248920 G/T cg12081754 chr8:22256438 SLC39A14 -1.02 -17.33 -0.69 1.93e-48 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1784581 0.588 rs9355971 chr6:162421242 A/G cg17173639 chr6:162384350 PARK2 0.57 9.91 0.48 1.8e-20 Itch intensity from mosquito bite; LUSC trans rs1268789 0.545 rs10026662 chr4:79372856 A/C cg06112894 chr8:141469983 TRAPPC9 0.23 6.26 0.32 1.19e-9 Hair shape;Hair morphology; LUSC cis rs6906287 0.647 rs12203006 chr6:118917086 C/T cg21191810 chr6:118973309 C6orf204 0.32 5.92 0.31 7.82e-9 Electrocardiographic conduction measures; LUSC trans rs8073060 0.505 rs225270 chr17:33968871 A/T cg19694781 chr19:47549865 TMEM160 -1.13 -17.82 -0.7 2.14e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg04844267 chr4:1394941 NA 0.3 5.95 0.31 6.6e-9 Obesity-related traits; LUSC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg00343986 chr7:65444356 GUSB 0.47 6.99 0.36 1.47e-11 Aortic root size; LUSC cis rs1018836 0.923 rs7833025 chr8:91568470 G/C cg16814680 chr8:91681699 NA -0.76 -12.82 -0.57 7.37e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9611519 0.828 rs4822008 chr22:41539206 C/G cg13813247 chr22:41461852 NA -0.38 -6.82 -0.35 4.38e-11 Neuroticism; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -6.13 -0.32 2.45e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1784581 0.588 rs7453474 chr6:162421736 C/T cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.06e-20 Itch intensity from mosquito bite; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18373944 chr11:33722333 C11orf91 0.44 6.56 0.34 2.11e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03364193 chr7:100167564 NA 0.71 6.4 0.33 5.29e-10 Cognitive performance; LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg27572855 chr1:25598939 RHD 0.49 8.88 0.44 4.31e-17 Erythrocyte sedimentation rate; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg04518342 chr5:131593106 PDLIM4 0.42 7.47 0.38 7.28e-13 Breast cancer; LUSC cis rs6545883 0.899 rs1562309 chr2:61770126 C/A cg15711740 chr2:61764176 XPO1 -0.5 -7.94 -0.4 3.21e-14 Tuberculosis; LUSC cis rs7177699 0.581 rs7165081 chr15:79123396 C/G cg15571903 chr15:79123663 NA 0.34 6.34 0.33 7.41e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs12310956 0.532 rs6488187 chr12:33975029 C/T cg13010199 chr12:38710504 ALG10B 0.49 7.37 0.37 1.32e-12 Morning vs. evening chronotype; LUSC cis rs12048904 0.541 rs1571046 chr1:101299216 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.91 13.56 0.6 1.14e-33 Multiple sclerosis; LUSC cis rs308403 0.509 rs309357 chr4:123653576 G/T cg10495464 chr4:123653540 BBS12;LOC729338 0.97 18.22 0.71 5.31e-52 Blood protein levels; LUSC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg14949292 chr17:78079608 GAA -0.31 -5.87 -0.31 1.06e-8 Yeast infection; LUSC cis rs9790314 0.905 rs6789388 chr3:160970437 G/A cg04691961 chr3:161091175 C3orf57 -0.35 -5.9 -0.31 8.87e-9 Morning vs. evening chronotype; LUSC cis rs4285028 0.580 rs2293611 chr3:121643163 G/C cg20356878 chr3:121714668 ILDR1 -0.45 -6.81 -0.35 4.63e-11 Multiple sclerosis; LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg22166914 chr1:53195759 ZYG11B 0.47 7.67 0.39 1.93e-13 Monocyte count; LUSC cis rs2109514 0.774 rs6954077 chr7:116129153 G/A cg12739419 chr7:116140593 CAV2 -0.27 -5.77 -0.3 1.77e-8 Prevalent atrial fibrillation; LUSC cis rs4786125 0.581 rs1473519 chr16:6921533 G/A cg03623568 chr16:6915990 A2BP1 -0.45 -7.56 -0.38 4.05e-13 Heart rate variability traits (SDNN); LUSC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg17971929 chr21:40555470 PSMG1 0.79 13.97 0.61 3.04e-35 Cognitive function; LUSC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg19592336 chr6:28129416 ZNF389 -0.52 -6.78 -0.35 5.56e-11 Parkinson's disease; LUSC cis rs1371867 0.810 rs1618528 chr8:101259134 T/C cg06002616 chr8:101225028 SPAG1 0.45 7.36 0.37 1.45e-12 Atrioventricular conduction; LUSC cis rs9905704 0.647 rs3809723 chr17:57061978 T/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.64 -0.39 2.27e-13 Testicular germ cell tumor; LUSC cis rs6840360 1.000 rs10019048 chr4:152603615 A/G cg22705602 chr4:152727874 NA -0.29 -6.24 -0.32 1.36e-9 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg20503657 chr10:835505 NA 0.79 9.87 0.48 2.49e-20 Eosinophil percentage of granulocytes; LUSC trans rs1814175 0.645 rs28538913 chr11:50040718 C/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg14004847 chr7:1930337 MAD1L1 -0.58 -9.01 -0.44 1.64e-17 Bipolar disorder and schizophrenia; LUSC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg03517284 chr6:25882590 NA -0.39 -6.86 -0.35 3.33e-11 Height; LUSC cis rs2652834 0.718 rs2652813 chr15:63405366 G/A cg05507819 chr15:63340323 TPM1 0.56 7.17 0.37 4.99e-12 HDL cholesterol; LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg25767906 chr1:53392781 SCP2 0.48 8.56 0.42 4.16e-16 Monocyte count; LUSC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.47 0.38 6.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 8.33e-17 Prudent dietary pattern; LUSC cis rs6121246 0.609 rs6088997 chr20:30289824 A/G cg13852791 chr20:30311386 BCL2L1 -0.89 -13.3 -0.59 1.11e-32 Mean corpuscular hemoglobin; LUSC cis rs35146811 0.735 rs1727130 chr7:99811464 C/G cg22906224 chr7:99728672 NA -0.47 -6.52 -0.34 2.56e-10 Coronary artery disease; LUSC cis rs9300255 0.602 rs11057192 chr12:123693420 T/C cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.3 -0.33 9.56e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg00339695 chr16:24857497 SLC5A11 0.4 7.3 0.37 2.11e-12 Intelligence (multi-trait analysis); LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg26962342 chr5:153418526 MFAP3;FAM114A2 -0.45 -6.58 -0.34 1.83e-10 QT interval (ambient particulate matter interaction); LUSC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg24558204 chr6:135376177 HBS1L 0.67 10.54 0.5 1.27e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg24812749 chr6:127587940 RNF146 0.92 13.86 0.6 7.98e-35 Breast cancer; LUSC cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg24642439 chr20:33292090 TP53INP2 -0.5 -7.5 -0.38 5.92e-13 Glomerular filtration rate (creatinine); LUSC cis rs1044826 0.642 rs2071388 chr3:139236683 C/T cg15131784 chr3:139108705 COPB2 -0.41 -6.52 -0.34 2.58e-10 Obesity-related traits; LUSC cis rs4660306 0.677 rs781060 chr1:45934166 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.42 5.88 0.31 1.01e-8 Homocysteine levels; LUSC cis rs9549260 0.651 rs57735994 chr13:41226561 C/G cg21288729 chr13:41239152 FOXO1 0.65 10.04 0.48 6.48e-21 Red blood cell count; LUSC cis rs62400317 0.859 rs12193812 chr6:45140761 C/T cg18551225 chr6:44695536 NA -0.42 -6.9 -0.35 2.69e-11 Total body bone mineral density; LUSC cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg15103426 chr22:29168792 CCDC117 0.5 6.87 0.35 3.17e-11 Lymphocyte counts; LUSC cis rs3091242 0.933 rs1534954 chr1:25761924 A/T cg03538708 chr1:25844672 NA -0.36 -5.95 -0.31 6.74e-9 Erythrocyte sedimentation rate; LUSC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.2e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.84 0.35 3.76e-11 Educational attainment; LUSC cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg22601191 chr20:60968625 CABLES2 0.57 9.8 0.47 4.23e-20 Colorectal cancer; LUSC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg01570182 chr17:44337453 NA -0.69 -10.4 -0.49 4.08e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 2.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3862030 0.720 rs2025713 chr10:104230156 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.97 -0.44 2.18e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7520050 0.807 rs6429576 chr1:46216575 T/C cg06784218 chr1:46089804 CCDC17 0.3 5.95 0.31 6.92e-9 Red blood cell count;Reticulocyte count; LUSC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg26513180 chr16:89883248 FANCA -0.75 -6.34 -0.33 7.54e-10 Skin colour saturation; LUSC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg10295955 chr4:187884368 NA -1.07 -25.94 -0.82 4.9e-82 Lobe attachment (rater-scored or self-reported); LUSC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg06713675 chr4:122721982 EXOSC9 -0.72 -12.31 -0.56 5.85e-29 Type 2 diabetes; LUSC cis rs3744061 0.557 rs9909137 chr17:74648029 G/A cg27546012 chr17:74684504 MXRA7 -0.37 -6.33 -0.33 8.13e-10 Retinal arteriolar caliber; LUSC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg11812906 chr14:75593930 NEK9 0.39 5.77 0.3 1.85e-8 Caffeine consumption; LUSC cis rs4654899 1.000 rs10799686 chr1:21486445 A/T cg01072550 chr1:21505969 NA 0.53 8.11 0.41 9.91e-15 Superior frontal gyrus grey matter volume; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg23758822 chr17:41437982 NA 1.04 19.77 0.73 3.88e-58 Menopause (age at onset); LUSC cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -8.05 -0.4 1.5e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7903847 0.642 rs10882909 chr10:99137998 G/C cg20016023 chr10:99160130 RRP12 -0.34 -8.41 -0.42 1.22e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg23887609 chr12:130822674 PIWIL1 0.49 7.34 0.37 1.64e-12 Menopause (age at onset); LUSC cis rs12464483 0.524 rs4952172 chr2:30888286 A/G cg12454169 chr2:30669597 LCLAT1 -0.57 -7.66 -0.39 2.04e-13 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs17034641 1.000 rs10495929 chr2:46372174 A/G cg12428440 chr2:46370979 PRKCE -0.47 -6.42 -0.33 4.57e-10 Hemoglobin;Hematocrit; LUSC cis rs4919687 0.550 rs7904252 chr10:104456725 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.4 5.85 0.3 1.16e-8 Colorectal cancer; LUSC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg16228356 chr17:43848958 NA -0.27 -6.29 -0.33 1e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.11 0.64 1.13e-39 Bladder cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04047827 chr16:24740859 TNRC6A 0.41 5.94 0.31 6.97e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg22532475 chr10:104410764 TRIM8 0.28 5.7 0.3 2.65e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg20406979 chr6:167373233 NA -0.26 -6.16 -0.32 2.1e-9 Crohn's disease; LUSC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg22535103 chr8:58192502 C8orf71 -0.82 -9.92 -0.48 1.67e-20 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.967 rs10863109 chr12:86328415 A/G cg00310523 chr12:86230176 RASSF9 0.4 7.18 0.37 4.67e-12 Major depressive disorder; LUSC cis rs597583 0.715 rs11216437 chr11:117394685 A/G cg27161313 chr11:117392002 DSCAML1 0.46 7.79 0.39 8.49e-14 Putamen volume; LUSC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg11764359 chr7:65958608 NA 0.61 9.15 0.45 5.77e-18 Aortic root size; LUSC cis rs11971779 0.680 rs10274480 chr7:139052428 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.06 0.36 9.47e-12 Diisocyanate-induced asthma; LUSC cis rs4930103 0.619 rs739905 chr11:1980360 G/C cg06197492 chr11:2016605 H19 0.43 6.95 0.36 1.92e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs68170813 0.559 rs77641084 chr7:106970522 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.56 -0.46 2.75e-19 Coronary artery disease; LUSC cis rs4950928 0.700 rs946263 chr1:203165381 A/G cg17014757 chr1:203156097 CHI3L1 0.39 6.31 0.33 8.84e-10 YKL-40 levels; LUSC trans rs1493916 0.905 rs4239383 chr18:31401066 T/C cg15819921 chr19:927150 ARID3A -0.44 -6.54 -0.34 2.26e-10 Life satisfaction; LUSC trans rs9650657 0.593 rs1968401 chr8:10615383 C/G cg15556689 chr8:8085844 FLJ10661 -0.41 -6.23 -0.32 1.36e-9 Neuroticism; LUSC cis rs9399135 0.967 rs10872427 chr6:135353452 T/C cg22676075 chr6:135203613 NA 0.46 7.27 0.37 2.56e-12 Red blood cell count; LUSC cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg13535736 chr9:111863775 C9orf5 -0.39 -6.41 -0.33 4.93e-10 Menarche (age at onset); LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.02 0.44 1.52e-17 Prudent dietary pattern; LUSC cis rs1113500 0.836 rs1618973 chr1:108586767 T/C cg06207961 chr1:108661230 NA -0.37 -6.82 -0.35 4.18e-11 Growth-regulated protein alpha levels; LUSC cis rs992157 0.710 rs56364928 chr2:219059058 G/A cg00012203 chr2:219082015 ARPC2 0.86 16.31 0.67 2.15e-44 Colorectal cancer; LUSC cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg18252515 chr7:66147081 NA -1.22 -13.8 -0.6 1.31e-34 Diabetic kidney disease; LUSC trans rs11098499 0.648 rs2002047 chr4:120257228 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.34e-10 Corneal astigmatism; LUSC cis rs9527 0.640 rs6584541 chr10:104929124 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.26e-10 Arsenic metabolism; LUSC cis rs9462027 0.651 rs9469870 chr6:34744349 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.73 -0.3 2.27e-8 Systemic lupus erythematosus; LUSC cis rs208515 0.556 rs12206707 chr6:66697182 A/G cg07460842 chr6:66804631 NA 1.08 14.6 0.62 1.08e-37 Exhaled nitric oxide levels; LUSC cis rs2952156 0.959 rs907087 chr17:37828787 G/A cg20243544 chr17:37824526 PNMT 0.51 7.42 0.38 9.72e-13 Asthma; LUSC cis rs208520 0.690 rs7764570 chr6:66827600 G/C cg07460842 chr6:66804631 NA -1.04 -16.3 -0.67 2.24e-44 Exhaled nitric oxide output; LUSC cis rs3768617 0.510 rs10458355 chr1:183063993 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.75 0.51 2.35e-23 Fuchs's corneal dystrophy; LUSC cis rs11098499 0.909 rs79026312 chr4:120440677 C/A cg09307838 chr4:120376055 NA 0.74 10.31 0.49 7.79e-22 Corneal astigmatism; LUSC cis rs4561483 0.583 rs1019813 chr16:11940829 C/T cg08843971 chr16:11963173 GSPT1 0.38 5.79 0.3 1.62e-8 Testicular germ cell tumor; LUSC cis rs754466 0.606 rs10824581 chr10:79599501 A/G cg17075019 chr10:79541650 NA -0.77 -12.29 -0.56 6.75e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs950776 0.518 rs2292117 chr15:78834689 C/T cg06917634 chr15:78832804 PSMA4 0.82 14.63 0.62 8.81e-38 Sudden cardiac arrest; LUSC cis rs71444571 1 rs71444571 chr12:123771015 G/A cg00376283 chr12:123451042 ABCB9 -0.72 -7.84 -0.39 5.96e-14 Lymphocyte percentage of white cells; LUSC cis rs7122539 0.646 rs608248 chr11:66562248 C/T cg18002602 chr11:66138449 SLC29A2 0.34 6.07 0.32 3.52e-9 HIV-1 susceptibility; LUSC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.16 0.45 5.19e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs7580658 0.963 rs10803585 chr2:128130108 G/A cg09760422 chr2:128146352 NA -0.33 -7.25 -0.37 2.91e-12 Protein C levels; LUSC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg05623727 chr3:50126028 RBM5 -0.33 -6.2 -0.32 1.65e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.62e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg00750074 chr16:89608354 SPG7 -0.55 -9.88 -0.48 2.29e-20 Multiple myeloma (IgH translocation); LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg00149659 chr3:10157352 C3orf10 0.89 12.15 0.55 2.18e-28 Alzheimer's disease; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg02181963 chr13:111358803 CARS2 -0.43 -5.95 -0.31 6.78e-9 Cognitive function;Information processing speed; LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.9 -0.48 1.99e-20 Platelet count; LUSC cis rs9362426 0.895 rs242292 chr6:88078074 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.38 6.1 0.32 2.97e-9 Depressive episodes in bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09184467 chr10:14995699 DCLRE1C 0.46 7.45 0.38 8.17e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs61774743 0.557 rs4660192 chr1:41842350 C/T cg08462924 chr1:41848221 NA 0.5 8.55 0.42 4.46e-16 Intelligence (multi-trait analysis); LUSC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg18477163 chr1:228402036 OBSCN -0.61 -11.64 -0.54 1.68e-26 Diastolic blood pressure; LUSC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.13e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs853679 0.882 rs3757188 chr6:28107357 T/C cg01620082 chr3:125678407 NA -0.6 -6.8 -0.35 4.77e-11 Depression; LUSC cis rs6545883 0.894 rs2463102 chr2:61571295 G/C cg15711740 chr2:61764176 XPO1 0.42 6.5 0.34 2.87e-10 Tuberculosis; LUSC cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC trans rs2786098 0.656 rs4915552 chr1:197512778 G/A cg16005942 chr6:160526640 IGF2R 0.5 6.04 0.31 4.13e-9 Asthma; LUSC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg15839431 chr19:19639596 YJEFN3 0.42 5.73 0.3 2.3e-8 Tonsillectomy; LUSC cis rs4776059 0.916 rs2414161 chr15:52883285 T/C cg25063058 chr15:52860530 ARPP19 0.47 6.48 0.33 3.27e-10 Schizophrenia; LUSC cis rs17685 0.753 rs11982200 chr7:75714883 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.84 -0.39 6.14e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7119167 0.686 rs6592520 chr11:73048267 T/G cg17517138 chr11:73019481 ARHGEF17 0.48 5.64 0.3 3.56e-8 Blood protein levels; LUSC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12950390 0.853 rs10445375 chr17:45864314 C/T cg06532163 chr17:45867833 NA -0.35 -6.5 -0.34 2.9e-10 IgG glycosylation; LUSC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg15335139 chr3:50242325 SLC38A3 0.25 5.71 0.3 2.49e-8 Body mass index; LUSC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg26668713 chr11:65405903 SIPA1 0.63 7.57 0.38 3.75e-13 Blood pressure (age interaction); LUSC trans rs2700987 0.692 rs1986567 chr7:37386650 C/G cg26076750 chr5:98105150 RGMB 0.37 6.53 0.34 2.39e-10 Psoriasis vulgaris;Psoriasis; LUSC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg06008330 chr7:65541103 ASL -0.41 -6.39 -0.33 5.68e-10 Aortic root size; LUSC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.575 rs11633309 chr15:76962349 C/A cg23625390 chr15:77176239 SCAPER -0.62 -8.9 -0.44 3.53e-17 Blood metabolite levels; LUSC trans rs2204008 0.806 rs35534445 chr12:38279093 C/T cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg21138405 chr5:131827807 IRF1 0.35 6.4 0.33 5.2e-10 Breast cancer;Mosquito bite size; LUSC cis rs9463078 0.585 rs1521355 chr6:44932755 T/C cg25276700 chr6:44698697 NA -0.28 -5.74 -0.3 2.17e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs12410462 0.681 rs4614224 chr1:227574966 C/T cg10327440 chr1:227177885 CDC42BPA -0.63 -5.93 -0.31 7.39e-9 Major depressive disorder; LUSC cis rs740160 0.510 rs11771702 chr7:98904300 C/G cg24650262 chr7:98904301 NA 0.62 6.85 0.35 3.54e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs11250464 0.833 rs11250467 chr10:1409662 A/G cg26394196 chr10:1453818 ADARB2 -0.37 -6.36 -0.33 6.48e-10 Radiation response; LUSC cis rs7408868 0.563 rs10423702 chr19:15300069 T/C cg14696996 chr19:15285081 NOTCH3 0.77 7.83 0.39 6.51e-14 Pulse pressure; LUSC cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg01579765 chr21:45077557 HSF2BP -0.49 -10.18 -0.49 2.16e-21 Mean corpuscular volume; LUSC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.52e-8 Extrinsic epigenetic age acceleration; LUSC cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20539690 chr10:101190675 GOT1 0.48 6.49 0.33 3.09e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2840044 1.000 rs225243 chr17:33947212 A/G cg05299278 chr17:33885742 SLFN14 0.3 6.23 0.32 1.39e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs10781543 0.839 rs7863766 chr9:139381314 T/G cg14019695 chr9:139328340 INPP5E 0.52 10.05 0.48 6.06e-21 Monocyte percentage of white cells; LUSC cis rs1577917 0.958 rs1447160 chr6:86546123 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.83 -0.35 4.14e-11 Response to antipsychotic treatment; LUSC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg05132306 chr1:1846340 CALML6 0.26 6.25 0.32 1.25e-9 Body mass index; LUSC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg08645402 chr16:4508243 NA -0.46 -7.26 -0.37 2.68e-12 Schizophrenia; LUSC cis rs1448094 0.836 rs7313442 chr12:86405642 C/T cg02569458 chr12:86230093 RASSF9 0.39 6.33 0.33 8.03e-10 Major depressive disorder; LUSC cis rs66887589 0.870 rs10518336 chr4:120522934 G/A cg09307838 chr4:120376055 NA 0.51 7.55 0.38 4.27e-13 Diastolic blood pressure; LUSC cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg23583168 chr7:148888333 NA -0.88 -16.83 -0.68 1.92e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7804356 1.000 rs12534899 chr7:26877189 C/T cg03456212 chr7:26904342 SKAP2 0.5 5.99 0.31 5.3e-9 Type 1 diabetes; LUSC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg24550644 chr17:30846204 MYO1D -0.44 -7.03 -0.36 1.14e-11 Schizophrenia; LUSC trans rs853679 0.607 rs35030260 chr6:28305508 G/A cg01620082 chr3:125678407 NA -0.86 -7.42 -0.38 9.7e-13 Depression; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg10862848 chr6:42927986 GNMT -0.29 -7.04 -0.36 1.08e-11 Plasma homocysteine levels (post-methionine load test); LUSC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg16372103 chr5:203701 NA -0.42 -5.81 -0.3 1.49e-8 Breast cancer; LUSC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg15664640 chr17:80829946 TBCD -0.74 -13.23 -0.59 2.12e-32 Breast cancer; LUSC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg12463550 chr7:65579703 CRCP -0.48 -7.17 -0.37 4.76e-12 Aortic root size; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.53 -8.13 -0.41 8.36e-15 Lymphocyte counts; LUSC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg03806693 chr22:41940476 POLR3H -1.0 -13.86 -0.6 8.31e-35 Vitiligo; LUSC trans rs1493916 1.000 rs4799729 chr18:31393521 C/T cg15819921 chr19:927150 ARID3A 0.42 6.0 0.31 5.2e-9 Life satisfaction; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg16405210 chr4:1374714 KIAA1530 -0.59 -9.37 -0.46 1.08e-18 Longevity; LUSC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg00784671 chr22:46762841 CELSR1 -0.48 -5.97 -0.31 6.22e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -7.83 -0.39 6.58e-14 Menarche (age at onset); LUSC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg07936489 chr17:37558343 FBXL20 -0.71 -9.74 -0.47 6.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg17541715 chr7:1216824 NA -0.39 -6.18 -0.32 1.92e-9 Longevity;Endometriosis; LUSC cis rs870825 0.860 rs72703519 chr4:185602707 G/A cg04058563 chr4:185651563 MLF1IP 0.77 10.26 0.49 1.17e-21 Blood protein levels; LUSC cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 11.98 0.55 9.49e-28 Colorectal cancer; LUSC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg11366901 chr6:160182831 ACAT2 0.93 13.01 0.58 1.34e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs1865721 0.771 rs724764 chr18:73139742 C/T cg26385618 chr18:73139727 C18orf62 -0.55 -10.12 -0.48 3.64e-21 Intelligence; LUSC cis rs9486715 0.838 rs7452350 chr6:96883326 C/A cg06623918 chr6:96969491 KIAA0776 0.93 17.58 0.69 1.94e-49 Headache; LUSC cis rs7091957 1.000 rs7091957 chr10:134439478 C/T cg27286337 chr10:134555280 INPP5A 0.6 9.41 0.46 8.4e-19 Gait speed in old age; LUSC cis rs977987 0.835 rs11641532 chr16:75329480 T/C cg03315344 chr16:75512273 CHST6 0.51 9.66 0.47 1.21e-19 Dupuytren's disease; LUSC cis rs7200543 1.000 rs1121 chr16:15131076 G/A cg03427771 chr16:15082598 PDXDC1 -0.42 -5.88 -0.31 9.86e-9 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs10197940 0.638 rs2288193 chr2:152348842 T/A cg06191203 chr2:152266755 RIF1 -0.56 -7.41 -0.38 1.05e-12 Lung cancer; LUSC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg23625390 chr15:77176239 SCAPER 0.52 8.01 0.4 1.99e-14 Blood metabolite levels; LUSC trans rs637571 0.726 rs526631 chr11:65681965 T/G cg17712092 chr4:129076599 LARP1B -0.97 -15.95 -0.66 5.71e-43 Eosinophil percentage of white cells; LUSC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg03351412 chr1:154909251 PMVK 0.52 7.94 0.4 3.18e-14 Prostate cancer; LUSC cis rs909341 0.903 rs1291205 chr20:62328829 C/G cg09650180 chr20:62225654 GMEB2 -0.45 -5.94 -0.31 7.04e-9 Atopic dermatitis; LUSC cis rs4343996 0.869 rs10232431 chr7:3511115 G/A cg21248987 chr7:3385318 SDK1 0.35 5.73 0.3 2.25e-8 Motion sickness; LUSC trans rs3960554 0.808 rs78587454 chr7:75688672 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 9.49 0.46 4.38e-19 Eotaxin levels; LUSC cis rs9900062 0.519 rs2676293 chr17:62710461 T/C cg02598441 chr17:62777298 LOC146880 -0.56 -7.29 -0.37 2.22e-12 QT interval; LUSC cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.91 0.31 8.5e-9 Rheumatoid arthritis; LUSC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg20476274 chr7:133979776 SLC35B4 0.88 16.91 0.68 9.02e-47 Mean platelet volume; LUSC cis rs72781680 0.821 rs12623521 chr2:24181670 C/T cg08917208 chr2:24149416 ATAD2B 0.6 6.94 0.35 2.07e-11 Lymphocyte counts; LUSC cis rs7089973 0.624 rs17586888 chr10:116598121 T/C cg03647239 chr10:116582469 FAM160B1 0.44 7.16 0.36 5.24e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg11663144 chr21:46675770 NA -0.41 -7.14 -0.36 5.99e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11971779 0.680 rs2355787 chr7:139089928 G/T cg07862535 chr7:139043722 LUC7L2 -0.59 -7.54 -0.38 4.45e-13 Diisocyanate-induced asthma; LUSC cis rs11622475 1.000 rs2236247 chr14:104378087 C/T cg12183467 chr14:104352244 NA -0.36 -6.58 -0.34 1.79e-10 Bipolar disorder; LUSC cis rs4499344 0.633 rs259239 chr19:33141090 C/T cg22980127 chr19:33182716 NUDT19 -0.39 -5.92 -0.31 7.99e-9 Mean platelet volume; LUSC cis rs72781680 1.000 rs6710426 chr2:24159288 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg11062466 chr8:58055876 NA 0.66 8.74 0.43 1.15e-16 Developmental language disorder (linguistic errors); LUSC cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg13010199 chr12:38710504 ALG10B 0.69 11.39 0.53 1.28e-25 Heart rate; LUSC trans rs8002861 0.967 rs9533689 chr13:44480413 A/C cg17145862 chr1:211918768 LPGAT1 0.23 6.1 0.32 2.97e-9 Leprosy; LUSC cis rs1670533 1.000 rs2290411 chr4:1051077 T/C cg16405210 chr4:1374714 KIAA1530 -0.46 -5.71 -0.3 2.44e-8 Recombination rate (females); LUSC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.83 13.01 0.58 1.33e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg17264618 chr3:40429014 ENTPD3 0.32 7.01 0.36 1.3e-11 Renal cell carcinoma; LUSC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.28 -0.45 2.26e-18 Gut microbiome composition (summer); LUSC cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg04455712 chr21:45112962 RRP1B 0.46 8.62 0.43 2.73e-16 Mean corpuscular volume; LUSC cis rs12986413 1.000 rs12982593 chr19:2175891 C/A cg09261902 chr19:2140048 AP3D1 0.31 5.93 0.31 7.5e-9 Height; LUSC trans rs1493916 0.905 rs12455290 chr18:31398778 A/G cg13755796 chr4:20253514 NA -0.44 -6.9 -0.35 2.56e-11 Life satisfaction; LUSC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg21699342 chr2:239360505 ASB1 0.43 6.66 0.34 1.14e-10 Multiple system atrophy; LUSC cis rs870825 0.587 rs58332461 chr4:185639742 G/A cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs642803 0.591 rs620088 chr11:65508986 G/A cg02870584 chr11:65547924 DKFZp761E198 0.44 5.96 0.31 6.3e-9 Urate levels; LUSC trans rs2524005 1.000 rs2524005 chr6:29899677 C/T cg06606381 chr12:133084897 FBRSL1 -0.58 -8.76 -0.43 9.71e-17 Bipolar disorder and schizophrenia; LUSC cis rs508618 0.697 rs7534248 chr1:231554531 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.58 7.08 0.36 8.71e-12 Red blood cell count; LUSC cis rs2742234 0.541 rs4648313 chr10:43716739 G/A cg02780029 chr10:43622663 RET 0.35 5.82 0.3 1.41e-8 Hirschsprung disease; LUSC cis rs7605827 0.930 rs1019360 chr2:15524741 C/T cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs9463078 0.764 rs9395051 chr6:44825715 C/A cg25276700 chr6:44698697 NA -0.28 -5.72 -0.3 2.38e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg10053473 chr17:62856997 LRRC37A3 -0.81 -12.24 -0.56 1e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg05623727 chr3:50126028 RBM5 0.32 5.98 0.31 5.61e-9 Body mass index; LUSC trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg15556689 chr8:8085844 FLJ10661 0.54 7.78 0.39 9.28e-14 Neuroticism; LUSC cis rs4908769 0.624 rs2708630 chr1:8447404 C/T cg00546117 chr1:8445545 RERE 0.3 6.04 0.31 4.09e-9 Allergy; LUSC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg20607287 chr7:12443886 VWDE -0.6 -7.29 -0.37 2.31e-12 Coronary artery disease; LUSC cis rs1577917 1.000 rs1415753 chr6:86753074 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.4 -0.42 1.27e-15 Response to antipsychotic treatment; LUSC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg17971929 chr21:40555470 PSMG1 0.79 13.88 0.6 6.93e-35 Cognitive function; LUSC cis rs2014572 0.967 rs10413671 chr19:57763489 G/A cg24459738 chr19:57751996 ZNF805 -0.51 -7.67 -0.39 1.87e-13 Hyperactive-impulsive symptoms; LUSC cis rs3093024 0.595 rs4412174 chr6:167476066 A/G cg06454157 chr6:167490870 NA -0.29 -6.77 -0.35 5.66e-11 Rheumatoid arthritis; LUSC cis rs250677 0.687 rs168750 chr5:148446756 A/G cg23229984 chr5:148520753 ABLIM3 0.41 6.48 0.33 3.22e-10 Breast cancer; LUSC cis rs950027 0.620 rs1617984 chr15:45622662 A/G cg14582100 chr15:45693742 SPATA5L1 0.47 8.62 0.43 2.72e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs12618769 0.597 rs4851138 chr2:99065464 A/C cg10123293 chr2:99228465 UNC50 0.45 7.71 0.39 1.46e-13 Bipolar disorder; LUSC cis rs2197308 0.765 rs11182434 chr12:37923968 C/A cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg19539972 chr4:7069911 GRPEL1 -0.69 -7.13 -0.36 6.07e-12 Monocyte percentage of white cells; LUSC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg22903471 chr2:27725779 GCKR -0.41 -7.07 -0.36 8.93e-12 Total body bone mineral density; LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg11965913 chr1:205819406 PM20D1 0.59 10.28 0.49 1.02e-21 Menarche (age at onset); LUSC cis rs3736594 0.513 rs6547735 chr2:27831607 T/C cg27432699 chr2:27873401 GPN1 0.62 8.48 0.42 7.18e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs17255340 0.539 rs10455140 chr6:84059498 G/A cg08257003 chr6:84140564 ME1 0.34 8.26 0.41 3.45e-15 Platelet-derived growth factor BB levels; LUSC trans rs7726839 0.540 rs72703078 chr5:594987 A/C cg11887960 chr12:57824829 NA 0.54 6.8 0.35 4.89e-11 Obesity-related traits; LUSC cis rs897080 0.552 rs1067397 chr2:44679285 A/T cg00619915 chr2:44497795 NA -0.45 -6.51 -0.34 2.82e-10 Height; LUSC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg16060761 chr17:80687452 NA -0.52 -8.03 -0.4 1.73e-14 Glycated hemoglobin levels; LUSC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg11871910 chr12:69753446 YEATS4 0.64 9.51 0.46 3.95e-19 Blood protein levels; LUSC trans rs1973993 0.691 rs11165623 chr1:96893000 G/A cg10631902 chr5:14652156 NA 0.6 10.55 0.5 1.19e-22 Weight; LUSC cis rs27434 0.583 rs34756 chr5:96152383 C/T cg16492584 chr5:96139282 ERAP1 0.46 6.49 0.33 3.06e-10 Ankylosing spondylitis; LUSC cis rs67340775 0.748 rs13212651 chr6:27806985 A/G cg26958806 chr6:27640298 NA 0.81 6.28 0.32 1.05e-9 Lung cancer in ever smokers; LUSC cis rs7408868 1.000 rs7254269 chr19:15277429 A/T cg14696996 chr19:15285081 NOTCH3 -0.91 -9.16 -0.45 5.24e-18 Pulse pressure; LUSC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg23711669 chr6:146136114 FBXO30 -0.82 -14.93 -0.63 5.87e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg27572855 chr1:25598939 RHD -0.41 -7.29 -0.37 2.26e-12 Erythrocyte sedimentation rate; LUSC cis rs2030746 0.521 rs13415147 chr2:121329768 A/G cg03661458 chr2:121334411 NA -0.3 -5.78 -0.3 1.71e-8 LDL cholesterol;Total cholesterol levels;LDL cholesterol levels; LUSC cis rs950776 0.752 rs62010327 chr15:78892784 G/A cg22563815 chr15:78856949 CHRNA5 0.24 5.75 0.3 1.96e-8 Sudden cardiac arrest; LUSC trans rs11098499 0.863 rs10019674 chr4:120443489 C/T cg25214090 chr10:38739885 LOC399744 -0.52 -7.47 -0.38 7.16e-13 Corneal astigmatism; LUSC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 7.12 0.36 6.47e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg05855489 chr10:104503620 C10orf26 -0.59 -9.73 -0.47 7.31e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg21963583 chr11:68658836 MRPL21 0.56 8.54 0.42 4.94e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg20503657 chr10:835505 NA -0.51 -7.03 -0.36 1.16e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg26380479 chr7:97908229 NA -0.27 -6.14 -0.32 2.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs72781680 0.846 rs72782114 chr2:24025740 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.7 0.47 9.46e-20 Lymphocyte counts; LUSC cis rs11098499 0.863 rs1383532 chr4:120434404 A/T cg09307838 chr4:120376055 NA -0.72 -10.52 -0.5 1.53e-22 Corneal astigmatism; LUSC cis rs7572644 0.620 rs6547816 chr2:28169597 T/C cg27432699 chr2:27873401 GPN1 -0.52 -6.51 -0.34 2.83e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4555082 0.874 rs56263609 chr14:105756944 C/T cg27165867 chr14:105738592 BRF1 -0.52 -7.25 -0.37 2.89e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg05025164 chr4:1340916 KIAA1530 -0.55 -8.42 -0.42 1.13e-15 Longevity; LUSC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg11608241 chr8:8085544 FLJ10661 0.43 6.47 0.33 3.57e-10 Mood instability; LUSC cis rs1018836 0.859 rs10808614 chr8:91569677 C/G cg16814680 chr8:91681699 NA -0.69 -11.11 -0.52 1.28e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg03929089 chr4:120376271 NA -0.76 -12.16 -0.55 1.96e-28 Height; LUSC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs253664 1.000 rs4346503 chr3:138107597 A/G cg25188949 chr3:137893707 DBR1 -0.49 -5.88 -0.31 9.73e-9 Body mass index; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01906555 chr2:74776410 LOXL3 -0.47 -6.25 -0.32 1.24e-9 Hepatitis; LUSC cis rs2797160 0.967 rs926854 chr6:126021780 A/G cg05901451 chr6:126070800 HEY2 0.57 8.76 0.43 1.03e-16 Endometrial cancer; LUSC cis rs1348850 0.915 rs10930798 chr2:178446141 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 6.62 0.34 1.4e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs983392 0.678 rs4938931 chr11:60026613 G/T cg24026212 chr11:59952134 MS4A6A 0.35 6.09 0.32 3.12e-9 Alzheimer's disease (late onset); LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.79 -0.39 8.61e-14 Lymphocyte counts; LUSC trans rs370763 0.660 rs264776 chr5:64395452 C/T cg26054548 chr3:62802561 CADPS 0.37 5.97 0.31 6.03e-9 Inguinal hernia; LUSC cis rs11190604 1.000 rs7085439 chr10:102210100 C/T cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1371867 0.846 rs1788206 chr8:101306966 A/G cg00191853 chr8:101177733 SPAG1 -0.41 -6.59 -0.34 1.68e-10 Atrioventricular conduction; LUSC cis rs3540 0.576 rs1974519 chr15:91036460 A/G cg10434728 chr15:90938212 IQGAP1 0.46 9.17 0.45 4.94e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs5769707 0.521 rs9616715 chr22:50058582 C/T cg20744362 chr22:50050164 C22orf34 0.36 6.66 0.34 1.1e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg14895029 chr7:2775587 GNA12 -0.4 -6.11 -0.32 2.8e-9 Height; LUSC cis rs9303401 0.659 rs12940212 chr17:56674474 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.17 0.58 3.41e-32 Cognitive test performance; LUSC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.43 0.56 1.99e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14495033 chr9:140707378 EHMT1 -0.41 -6.64 -0.34 1.29e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9811920 0.809 rs766778 chr3:99751480 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -6.79 -0.35 5.03e-11 Axial length; LUSC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.58e-8 Life satisfaction; LUSC trans rs62055045 0.528 rs62056191 chr16:71533831 C/T cg09088153 chr15:96890598 NA -0.47 -6.42 -0.33 4.68e-10 Schizophrenia; LUSC cis rs1371867 0.875 rs1788178 chr8:101332518 A/C cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg14552801 chr7:65878734 NA 0.38 5.83 0.3 1.33e-8 Aortic root size; LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -6.38 -0.33 6e-10 Longevity;Endometriosis; LUSC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg21171335 chr12:122356390 WDR66 0.65 9.79 0.47 4.74e-20 Mean corpuscular volume; LUSC cis rs1003719 0.762 rs3787787 chr21:38463452 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC trans rs2197308 0.715 rs11181816 chr12:37911626 A/G cg06521331 chr12:34319734 NA 0.4 6.32 0.33 8.45e-10 Morning vs. evening chronotype; LUSC cis rs4947962 0.564 rs2330948 chr7:55080356 A/G cg23757825 chr7:55092271 EGFR 0.69 8.77 0.43 9.39e-17 Subjective response to lithium treatment; LUSC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg03806693 chr22:41940476 POLR3H 0.97 14.15 0.61 6.21e-36 Vitiligo; LUSC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg18876405 chr7:65276391 NA -0.58 -9.46 -0.46 5.63e-19 Aortic root size; LUSC trans rs7819412 0.691 rs73198970 chr8:11040216 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.06 -0.36 9.76e-12 Triglycerides; LUSC cis rs2282300 0.739 rs1222210 chr11:30362125 A/G cg25418670 chr11:30344373 C11orf46 0.61 8.86 0.44 4.67e-17 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg09021430 chr5:549028 NA -0.54 -7.46 -0.38 7.38e-13 Lung disease severity in cystic fibrosis; LUSC cis rs9399135 0.967 rs4451151 chr6:135310546 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.27 0.45 2.41e-18 Red blood cell count; LUSC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg15649852 chr7:65879115 NA -0.4 -5.65 -0.3 3.44e-8 Aortic root size; LUSC cis rs1348850 0.914 rs4893944 chr2:178289357 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 7.5 0.38 5.7e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs948562 0.647 rs71486418 chr11:58240133 C/T cg15696309 chr11:58395628 NA -0.42 -5.96 -0.31 6.47e-9 Lymphoma; LUSC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg06363034 chr20:62225388 GMEB2 0.46 7.86 0.4 5.4e-14 Glioblastoma; LUSC cis rs7224314 1.000 rs8066725 chr17:65387326 G/A cg01507342 chr17:65387096 PITPNC1 -0.44 -7.79 -0.39 8.5e-14 Diisocyanate-induced asthma; LUSC cis rs6543140 0.964 rs6748390 chr2:103062175 A/G cg09003973 chr2:102972529 NA 0.53 6.91 0.35 2.45e-11 Blood protein levels; LUSC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.55 0.34 2.17e-10 Mean platelet volume; LUSC cis rs516243 0.871 rs3748687 chr1:10736216 G/A cg02903756 chr1:10750680 CASZ1 -0.46 -8.12 -0.41 9.35e-15 Migraine - clinic-based; LUSC cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.71e-9 Body mass index; LUSC cis rs28655083 0.956 rs11863953 chr16:77065710 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.41 -6.08 -0.32 3.2e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg05855489 chr10:104503620 C10orf26 0.55 8.05 0.4 1.47e-14 Arsenic metabolism; LUSC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg15839431 chr19:19639596 YJEFN3 -0.42 -6.09 -0.32 3.16e-9 Tonsillectomy; LUSC cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg11244672 chr19:19639970 YJEFN3 -0.57 -6.94 -0.35 2.06e-11 Bipolar disorder; LUSC cis rs12801636 0.512 rs7119750 chr11:65422591 C/T cg24147428 chr11:65409760 SIPA1 -0.5 -5.81 -0.3 1.45e-8 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18051889 chr17:53046101 COX11;STXBP4 0.43 6.25 0.32 1.24e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg16145915 chr7:1198662 ZFAND2A -0.65 -12.57 -0.57 6.15e-30 Longevity;Endometriosis; LUSC cis rs2425143 1.000 rs73902914 chr20:34432882 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.89 -0.31 9.2e-9 Blood protein levels; LUSC cis rs7586879 0.616 rs916485 chr2:25082273 T/C cg01884057 chr2:25150051 NA 0.43 9.99 0.48 9.54e-21 Body mass index; LUSC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs3845702 0.866 rs3914458 chr2:180862606 A/G cg01881094 chr2:180872142 CWC22 -0.8 -10.28 -0.49 1.03e-21 Schizophrenia; LUSC trans rs2018683 0.933 rs12536127 chr7:28985967 T/C cg19402173 chr7:128379420 CALU -0.54 -8.6 -0.43 3.22e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs72781680 1.000 rs72781643 chr2:24208746 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.16 0.32 2.1e-9 Lymphocyte counts; LUSC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg00933542 chr6:150070202 PCMT1 0.32 6.8 0.35 4.8e-11 Lung cancer; LUSC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg02187348 chr16:89574699 SPG7 0.48 7.09 0.36 8.07e-12 Multiple myeloma (IgH translocation); LUSC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC cis rs9457247 1.000 rs413232 chr6:167400972 G/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.74 -0.35 6.85e-11 Crohn's disease; LUSC cis rs9467773 1.000 rs28558133 chr6:26531433 G/C cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.88e-18 Intelligence (multi-trait analysis); LUSC trans rs4332037 0.851 rs34040190 chr7:1920356 G/A cg25206134 chr2:45395956 NA 0.6 6.33 0.33 7.71e-10 Bipolar disorder; LUSC trans rs941408 0.890 rs1640269 chr19:2793194 A/C cg19676328 chr12:49525230 TUBA1B -0.53 -8.12 -0.41 9.28e-15 Total cholesterol levels; LUSC trans rs931812 0.757 rs4734015 chr8:101909258 C/G cg20993868 chr7:22813445 NA 0.53 9.99 0.48 9.81e-21 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs6076065 0.723 rs2275788 chr20:23338694 G/A cg11657817 chr20:23433608 CST11 0.43 8.03 0.4 1.7e-14 Facial morphology (factor 15, philtrum width); LUSC trans rs6445975 0.617 rs13071422 chr3:58398813 A/G cg18950693 chr14:70346909 SMOC1 -0.4 -6.05 -0.31 3.87e-9 Systemic lupus erythematosus; LUSC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg08109568 chr15:31115862 NA -0.74 -11.04 -0.52 2.25e-24 Huntington's disease progression; LUSC cis rs4343996 1.000 rs4343996 chr7:3362642 G/A cg21248987 chr7:3385318 SDK1 -0.38 -6.42 -0.33 4.75e-10 Motion sickness; LUSC cis rs6754311 0.731 rs309168 chr2:136670298 C/T cg07169764 chr2:136633963 MCM6 0.52 7.2 0.37 4.1e-12 Mosquito bite size; LUSC cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.83e-11 Intelligence (multi-trait analysis); LUSC cis rs7100689 0.784 rs3802638 chr10:82179689 T/C cg01528321 chr10:82214614 TSPAN14 1.12 18.04 0.7 2.77e-51 Post bronchodilator FEV1; LUSC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg24562669 chr7:97807699 LMTK2 0.36 6.31 0.33 8.61e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs11650494 0.901 rs117087923 chr17:47364913 G/A cg08112188 chr17:47440006 ZNF652 1.22 10.33 0.49 6.95e-22 Prostate cancer; LUSC cis rs6545883 0.894 rs10177303 chr2:61594459 G/A cg15711740 chr2:61764176 XPO1 0.42 6.34 0.33 7.38e-10 Tuberculosis; LUSC cis rs7681440 0.904 rs1442153 chr4:90775719 T/G cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.23e-8 Dementia with Lewy bodies; LUSC cis rs2011503 0.739 rs10412176 chr19:19689164 T/C cg11244672 chr19:19639970 YJEFN3 0.47 6.16 0.32 2.12e-9 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16326998 chr7:5553266 FBXL18 -0.51 -6.41 -0.33 4.82e-10 Bipolar disorder and schizophrenia; LUSC cis rs238295 0.805 rs6038214 chr20:5569822 C/G cg15842884 chr20:5591925 RP5-1022P6.2 0.43 5.95 0.31 6.92e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg01802117 chr1:53393560 SCP2 -0.39 -6.45 -0.33 3.94e-10 Monocyte count; LUSC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg15605315 chr1:45957053 TESK2 0.47 7.49 0.38 6.26e-13 High light scatter reticulocyte count; LUSC cis rs9303401 0.659 rs61291849 chr17:56909867 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.67 0.6 4.46e-34 Cognitive test performance; LUSC cis rs7681440 0.874 rs1442151 chr4:90775491 T/A cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.31 1.15e-8 Dementia with Lewy bodies; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg13047869 chr3:10149882 C3orf24 0.66 9.53 0.46 3.37e-19 Alzheimer's disease; LUSC trans rs10486158 0.843 rs2191818 chr7:7381902 C/A cg01895333 chr3:109035405 DPPA2 -0.37 -6.01 -0.31 4.76e-9 Bipolar disorder and schizophrenia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09827037 chr3:5028674 NA 0.37 6.1 0.32 2.96e-9 Asthma; LUSC trans rs11743006 0.589 rs11750026 chr5:136499798 T/C cg07379741 chr17:7311030 NLGN2 0.4 6.01 0.31 4.78e-9 Mathematical ability; LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg27170947 chr2:26402098 FAM59B 0.6 8.53 0.42 5.22e-16 Gut microbiome composition (summer); LUSC cis rs2625529 0.556 rs11630611 chr15:72466312 C/T cg16672083 chr15:72433130 SENP8 0.5 8.0 0.4 2.14e-14 Red blood cell count; LUSC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg23093090 chr10:104574429 C10orf26 -0.45 -7.93 -0.4 3.35e-14 Arsenic metabolism; LUSC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg02079420 chr8:82753780 SNX16 0.41 6.97 0.36 1.69e-11 Diastolic blood pressure; LUSC cis rs9393777 0.623 rs9358948 chr6:26483806 G/A cg12826209 chr6:26865740 GUSBL1 0.68 7.67 0.39 1.85e-13 Intelligence (multi-trait analysis); LUSC trans rs17039065 1.000 rs17039065 chr4:109385403 C/T cg07444054 chr2:108107501 NA 0.44 6.41 0.33 5e-10 Gut microbiome composition (summer); LUSC cis rs10109025 0.701 rs10101292 chr8:10856474 T/C cg21775007 chr8:11205619 TDH -0.42 -5.86 -0.31 1.1e-8 Joint mobility (Beighton score); LUSC cis rs9399401 0.884 rs6570510 chr6:142755024 C/T cg03128060 chr6:142623767 GPR126 0.31 5.79 0.3 1.61e-8 Chronic obstructive pulmonary disease; LUSC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.6 -12.56 -0.57 6.52e-30 Monocyte percentage of white cells; LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.4 0.62 6.35e-37 Platelet count; LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.82 -0.35 4.24e-11 Menopause (age at onset); LUSC trans rs35110281 0.744 rs162373 chr21:44927107 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.59 -9.57 -0.46 2.41e-19 Mean corpuscular volume; LUSC cis rs1595825 0.735 rs113834557 chr2:198611624 A/G cg10547527 chr2:198650123 BOLL -0.52 -5.99 -0.31 5.45e-9 Ulcerative colitis; LUSC cis rs10911232 0.507 rs4266836 chr1:183029070 T/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.26 0.52 3.73e-25 Hypertriglyceridemia; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.7 0.39 1.61e-13 Prudent dietary pattern; LUSC cis rs4655582 0.510 rs11208700 chr1:66133443 A/T cg04111102 chr1:66153794 NA 0.26 5.64 0.3 3.56e-8 Fibrinogen levels; LUSC cis rs3020736 0.500 rs7364293 chr22:42506370 C/T cg15557168 chr22:42548783 NA 0.48 7.39 0.38 1.16e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs138918 0.772 rs138933 chr22:43565855 C/T cg08909806 chr22:43548696 TSPO 0.36 6.18 0.32 1.82e-9 Monocyte count; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg26314531 chr2:26401878 FAM59B -0.66 -9.44 -0.46 6.86e-19 Gut microbiome composition (summer); LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.17 -0.41 6.37e-15 Lymphocyte counts; LUSC cis rs4319547 0.656 rs7975747 chr12:122816995 C/T cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.45 -0.42 8.88e-16 Body mass index; LUSC trans rs1814175 0.684 rs1827015 chr11:49585241 A/G cg03929089 chr4:120376271 NA -0.88 -13.69 -0.6 3.54e-34 Height; LUSC cis rs453301 0.658 rs9329175 chr8:8866661 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -7.15 -0.36 5.68e-12 Joint mobility (Beighton score); LUSC cis rs8060686 0.641 rs12446007 chr16:68189054 C/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04741861 chr19:3531604 FZR1 0.49 7.3 0.37 2.18e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10992471 0.528 rs3739606 chr9:95237222 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.19 -0.32 1.75e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6121246 0.738 rs2376996 chr20:30316667 T/A cg18721089 chr20:30220636 NA -0.34 -5.89 -0.31 9.62e-9 Mean corpuscular hemoglobin; LUSC cis rs28655083 0.912 rs2171097 chr16:77085037 C/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.45 -6.93 -0.35 2.2e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg16325326 chr1:53192061 ZYG11B -0.83 -14.56 -0.62 1.63e-37 Monocyte count; LUSC trans rs561341 1.000 rs8070262 chr17:30262467 A/G cg20587970 chr11:113659929 NA -0.98 -12.21 -0.56 1.38e-28 Hip circumference adjusted for BMI; LUSC cis rs55675132 0.620 rs2335722 chr1:115635991 G/A cg01522456 chr1:115632236 TSPAN2 0.47 6.54 0.34 2.31e-10 Schizophrenia; LUSC cis rs422421 1.000 rs2456173 chr5:176514595 T/C cg00618323 chr5:176515533 FGFR4 0.36 5.83 0.3 1.34e-8 Height; LUSC cis rs2281845 0.826 rs4915214 chr1:201076290 T/A cg22815214 chr1:201083145 CACNA1S 0.51 8.77 0.43 9.09e-17 Permanent tooth development; LUSC cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg03146154 chr1:46216737 IPP 0.54 8.17 0.41 6.65e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs67478160 0.608 rs4906368 chr14:104242397 A/C cg08213375 chr14:104286397 PPP1R13B 0.46 9.05 0.44 1.17e-17 Schizophrenia; LUSC cis rs1371867 0.875 rs28595052 chr8:101327553 G/A cg00191853 chr8:101177733 SPAG1 -0.4 -6.45 -0.33 3.86e-10 Atrioventricular conduction; LUSC cis rs7264396 0.887 rs1886696 chr20:34055706 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.46 -0.33 3.78e-10 Total cholesterol levels; LUSC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg21361702 chr7:150065534 REPIN1 0.57 8.03 0.4 1.65e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -6.25 -0.32 1.23e-9 Developmental language disorder (linguistic errors); LUSC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg04553112 chr3:125709451 NA -0.5 -5.67 -0.3 3.08e-8 Blood pressure (smoking interaction); LUSC cis rs7903847 0.620 rs954149 chr10:99122936 G/A cg08345082 chr10:99160200 RRP12 -0.36 -7.17 -0.37 5.01e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs10875746 0.903 rs11168420 chr12:48515896 C/T cg13454099 chr12:49076203 C12orf41 -0.49 -5.68 -0.3 2.95e-8 Longevity (90 years and older); LUSC cis rs72781680 1.000 rs72781643 chr2:24208746 G/A cg08917208 chr2:24149416 ATAD2B 0.9 10.09 0.48 4.34e-21 Lymphocyte counts; LUSC cis rs55883249 0.957 rs10495572 chr2:9734859 C/G cg23886495 chr2:9695866 ADAM17 -0.49 -5.75 -0.3 1.98e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2816062 0.813 rs2816044 chr1:18892826 A/G cg18795169 chr1:18902165 NA -0.99 -22.74 -0.78 8.19e-70 Urate levels in lean individuals; LUSC trans rs6590322 0.610 rs4937321 chr11:128216466 G/T cg19073447 chr10:134024191 STK32C 0.35 6.12 0.32 2.63e-9 Hippocampal atrophy; LUSC trans rs9467711 0.790 rs10484439 chr6:26309908 G/A cg06606381 chr12:133084897 FBRSL1 -0.69 -6.83 -0.35 4.02e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs12439619 0.508 rs8023960 chr15:82499045 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.47 -7.46 -0.38 7.3e-13 Intelligence (multi-trait analysis); LUSC cis rs10465746 0.780 rs12145258 chr1:84401211 G/A cg10977910 chr1:84465055 TTLL7 0.43 6.25 0.32 1.23e-9 Obesity-related traits; LUSC cis rs314370 0.951 rs12666989 chr7:100486754 G/C cg08558340 chr7:100472263 SRRT 0.51 6.37 0.33 6.41e-10 Resting heart rate; LUSC cis rs10791097 0.694 rs4937581 chr11:130740335 T/C cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg12560992 chr17:57184187 TRIM37 0.86 15.43 0.65 6.22e-41 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.662 rs3761143 chr20:33545745 C/T cg07148914 chr20:33460835 GGT7 0.48 7.14 0.36 5.69e-12 Height; LUSC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 14.46 0.62 3.7e-37 Platelet count; LUSC cis rs6430585 0.528 rs6743537 chr2:136702601 C/T cg07169764 chr2:136633963 MCM6 1.02 15.35 0.64 1.24e-40 Corneal structure; LUSC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.6 12.53 0.57 8.87e-30 Monocyte percentage of white cells; LUSC cis rs1538970 0.924 rs11211118 chr1:45930270 A/C cg05343316 chr1:45956843 TESK2 0.68 9.4 0.46 9.28e-19 Platelet count; LUSC cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg26850624 chr5:429559 AHRR -0.33 -5.82 -0.3 1.41e-8 Cystic fibrosis severity; LUSC trans rs7726839 0.540 rs61580655 chr5:597564 A/G cg25482853 chr8:67687455 SGK3 1.12 15.85 0.66 1.36e-42 Obesity-related traits; LUSC cis rs752010 0.655 rs10890145 chr1:42086290 A/G cg06885757 chr1:42089581 HIVEP3 0.48 10.11 0.48 3.75e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg06850241 chr22:41845214 NA 0.31 5.8 0.3 1.56e-8 Vitiligo; LUSC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs8114671 0.836 rs3746432 chr20:33592763 C/T cg07148914 chr20:33460835 GGT7 -0.44 -6.53 -0.34 2.4e-10 Height; LUSC cis rs4604732 0.527 rs7539082 chr1:247627260 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg15556689 chr8:8085844 FLJ10661 0.7 11.63 0.54 1.83e-26 Systolic blood pressure; LUSC cis rs2898290 0.622 rs978804 chr8:11343673 C/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.8 -0.35 4.86e-11 Systolic blood pressure; LUSC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.46 6.77 0.35 5.7e-11 Alzheimer's disease (late onset); LUSC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg05785598 chr3:49045655 WDR6 0.33 5.85 0.3 1.17e-8 Parkinson's disease; LUSC trans rs9401746 0.564 rs582822 chr6:124800907 T/C cg16857858 chr7:27213984 HOXA10 0.55 6.14 0.32 2.3e-9 Bone mineral density (Ward's triangle area); LUSC cis rs668210 0.793 rs540584 chr11:65765866 C/G cg04700828 chr11:65773979 NA 0.39 5.64 0.3 3.55e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg19678392 chr7:94953810 PON1 -0.38 -6.09 -0.32 3.07e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10779751 0.770 rs2258621 chr1:11141187 C/G cg08854313 chr1:11322531 MTOR 0.83 12.37 0.56 3.3e-29 Body mass index; LUSC cis rs950881 0.866 rs72823628 chr2:102928617 G/A cg20060108 chr2:102954350 IL1RL1 0.48 6.36 0.33 6.7e-10 Allergy; LUSC trans rs12310956 0.532 rs11052954 chr12:33993512 C/G cg13010199 chr12:38710504 ALG10B 0.52 7.71 0.39 1.43e-13 Morning vs. evening chronotype; LUSC cis rs2580764 0.565 rs6760429 chr2:55228499 C/T cg09592903 chr2:55203963 RTN4 -0.49 -10.05 -0.48 6.22e-21 Mean platelet volume; LUSC cis rs9329221 0.905 rs17765901 chr8:10249480 G/T cg21775007 chr8:11205619 TDH -0.57 -8.49 -0.42 6.72e-16 Neuroticism; LUSC cis rs10392 0.543 rs6015981 chr20:37533958 A/G cg27552599 chr20:37590471 DHX35 0.44 6.98 0.36 1.6e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs7577696 0.962 rs212745 chr2:32412832 C/G cg02381751 chr2:32503542 YIPF4 0.41 5.84 0.3 1.21e-8 Inflammatory biomarkers; LUSC cis rs2760061 0.819 rs708120 chr1:228207651 G/C cg20976159 chr1:228193529 WNT3A 0.28 5.71 0.3 2.54e-8 Diastolic blood pressure; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg10729496 chr3:10149963 C3orf24 -0.5 -7.01 -0.36 1.33e-11 Alzheimer's disease; LUSC cis rs9467773 1.000 rs6930120 chr6:26555484 A/G cg09904177 chr6:26538194 HMGN4 0.75 14.04 0.61 1.66e-35 Intelligence (multi-trait analysis); LUSC cis rs3820928 0.874 rs6728239 chr2:227856552 A/G cg11843606 chr2:227700838 RHBDD1 -0.51 -7.39 -0.37 1.19e-12 Pulmonary function; LUSC cis rs3845702 1.000 rs3768839 chr2:180835992 G/A cg01881094 chr2:180872142 CWC22 -0.82 -10.71 -0.51 3.19e-23 Schizophrenia; LUSC trans rs4295623 0.585 rs34421088 chr8:11589042 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.16 -0.32 2.08e-9 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg12310025 chr6:25882481 NA -0.47 -8.01 -0.4 1.93e-14 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.838 rs4785561 chr16:89429052 C/T cg00750074 chr16:89608354 SPG7 -0.47 -8.06 -0.4 1.38e-14 Multiple myeloma (IgH translocation); LUSC cis rs951366 0.576 rs7513645 chr1:205698026 A/G cg11965913 chr1:205819406 PM20D1 0.49 6.77 0.35 5.98e-11 Menarche (age at onset); LUSC trans rs7980799 0.682 rs1351682 chr12:33598775 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.43 -0.33 4.37e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs6681460 0.549 rs11208908 chr1:67036636 C/T cg02459107 chr1:67143332 SGIP1 0.31 5.66 0.3 3.25e-8 Presence of antiphospholipid antibodies; LUSC cis rs3743266 0.507 rs9630426 chr15:60739053 C/T cg21667061 chr15:60772094 NARG2 0.51 6.92 0.35 2.33e-11 Menarche (age at onset); LUSC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg17366294 chr4:99064904 C4orf37 0.57 9.91 0.48 1.76e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg03188948 chr7:1209495 NA 0.66 6.91 0.35 2.44e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.11 14.84 0.63 1.26e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7147624 1.000 rs10873192 chr14:66110653 A/G cg03016385 chr14:66212404 NA -0.82 -9.13 -0.45 6.88e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs829883 0.616 rs249832 chr12:98832387 C/T cg25150519 chr12:98850993 NA 0.8 13.45 0.59 3.01e-33 Colorectal adenoma (advanced); LUSC cis rs870825 0.616 rs28620459 chr4:185627132 G/C cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs593982 0.920 rs4930298 chr11:65448108 T/A cg08755490 chr11:65554678 OVOL1 -1.54 -12.26 -0.56 8.83e-29 Atopic dermatitis; LUSC cis rs6424115 1.000 rs7519554 chr1:24154566 T/A cg15997130 chr1:24165203 NA -0.53 -8.82 -0.43 6.68e-17 Immature fraction of reticulocytes; LUSC cis rs12493885 0.769 rs61791508 chr3:153750816 A/G cg17054900 chr3:154042577 DHX36 -0.57 -6.14 -0.32 2.39e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4691139 0.903 rs10434177 chr4:165915531 A/T cg08992305 chr4:165878219 TRIM61;C4orf39 -0.5 -5.92 -0.31 7.95e-9 Ovarian cancer in BRCA1 mutation carriers; LUSC cis rs9905704 0.846 rs2567894 chr17:56794115 G/A cg12560992 chr17:57184187 TRIM37 0.58 8.4 0.42 1.34e-15 Testicular germ cell tumor; LUSC cis rs11785400 0.793 rs4736362 chr8:143741381 G/A cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs72949976 0.678 rs7573232 chr2:214040425 C/T cg08319019 chr2:214017104 IKZF2 -0.53 -7.12 -0.36 6.76e-12 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs7107174 1.000 rs10899475 chr11:78051610 T/C cg27205649 chr11:78285834 NARS2 -0.51 -5.77 -0.3 1.77e-8 Testicular germ cell tumor; LUSC cis rs6961069 0.574 rs7784648 chr7:80232655 T/C cg04458919 chr7:80252533 CD36 -0.41 -7.17 -0.37 4.95e-12 Platelet count; LUSC cis rs10193935 1.000 rs4494804 chr2:42395946 A/T cg27598129 chr2:42591480 NA -0.59 -7.96 -0.4 2.75e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs9329221 0.905 rs13252982 chr8:10255105 C/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.1 -0.45 8.3e-18 Neuroticism; LUSC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg23758822 chr17:41437982 NA 1.0 18.94 0.72 7.62e-55 Menopause (age at onset); LUSC cis rs722599 0.683 rs8011071 chr14:75286705 T/C cg08847533 chr14:75593920 NEK9 0.44 6.18 0.32 1.84e-9 IgG glycosylation; LUSC cis rs5770917 1.000 rs2073604 chr22:51008925 G/A cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.57 -5.72 -0.3 2.31e-8 Narcolepsy; LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg24578937 chr1:2090814 PRKCZ 0.43 9.46 0.46 5.5e-19 Height; LUSC cis rs7100689 0.784 rs3120977 chr10:82075324 C/G cg00277334 chr10:82204260 NA -0.55 -7.63 -0.39 2.52e-13 Post bronchodilator FEV1; LUSC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.14 -0.45 6.39e-18 Gut microbiome composition (summer); LUSC trans rs7819412 0.505 rs17782536 chr8:11021682 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.14 -0.36 5.95e-12 Triglycerides; LUSC cis rs8038465 0.615 rs62004618 chr15:73962164 A/G cg15420318 chr15:73925796 NPTN 0.6 10.34 0.49 6.3e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9473147 0.543 rs9367279 chr6:47448336 A/G cg20196966 chr6:47445060 CD2AP 0.42 5.92 0.31 7.99e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs7072216 0.770 rs7896828 chr10:100170507 A/T cg26618903 chr10:100175079 PYROXD2 -0.34 -6.8 -0.35 4.85e-11 Metabolite levels; LUSC cis rs76878669 0.561 rs6591217 chr11:66174653 G/A cg18002602 chr11:66138449 SLC29A2 -0.46 -8.08 -0.4 1.17e-14 Educational attainment (years of education); LUSC cis rs950776 0.616 rs12901300 chr15:78892952 G/A cg06917634 chr15:78832804 PSMA4 0.75 13.1 0.58 6.18e-32 Sudden cardiac arrest; LUSC cis rs2274273 0.653 rs1209087 chr14:55493220 C/T cg04306507 chr14:55594613 LGALS3 -0.5 -11.04 -0.52 2.21e-24 Protein biomarker; LUSC cis rs921968 0.643 rs4674324 chr2:219523433 T/G cg02176678 chr2:219576539 TTLL4 0.59 10.62 0.5 6.58e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg18876405 chr7:65276391 NA 0.7 12.59 0.57 5.27e-30 Aortic root size; LUSC trans rs4689592 0.546 rs10937782 chr4:7057106 G/C cg07817883 chr1:32538562 TMEM39B -0.57 -6.88 -0.35 2.89e-11 Monocyte percentage of white cells; LUSC cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg25233709 chr10:116636983 FAM160B1 0.44 7.93 0.4 3.39e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg18190219 chr22:46762943 CELSR1 -0.48 -6.0 -0.31 5.01e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.0 -0.68 3.84e-47 Gut microbiome composition (summer); LUSC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.2 0.32 1.66e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg12463550 chr7:65579703 CRCP -0.43 -6.36 -0.33 6.61e-10 Aortic root size; LUSC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg12963246 chr6:28129442 ZNF389 0.52 7.18 0.37 4.53e-12 Depression; LUSC cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.43e-32 Chronic sinus infection; LUSC cis rs713587 0.646 rs2384061 chr2:25135620 C/T cg01884057 chr2:25150051 NA 0.42 9.8 0.47 4.44e-20 Body mass index in non-asthmatics; LUSC cis rs9393777 0.623 rs9358945 chr6:26472114 C/T cg09904177 chr6:26538194 HMGN4 0.51 5.77 0.3 1.8e-8 Intelligence (multi-trait analysis); LUSC cis rs4295623 0.585 rs13259242 chr8:11593033 T/G cg00262122 chr8:11665843 FDFT1 -0.44 -6.59 -0.34 1.68e-10 Morning vs. evening chronotype; LUSC cis rs7727544 0.716 rs7701414 chr5:131585958 A/G cg12564285 chr5:131593104 PDLIM4 0.37 6.85 0.35 3.49e-11 Blood metabolite levels; LUSC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg07636037 chr3:49044803 WDR6 1.03 18.04 0.7 2.76e-51 Parkinson's disease; LUSC trans rs9951602 0.512 rs4799247 chr18:76653449 G/A cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs61990749 0.597 rs2032781 chr14:78214875 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.62 6.59 0.34 1.76e-10 Fibroblast growth factor basic levels; LUSC trans rs10435719 0.899 rs9693925 chr8:11789963 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.05 0.31 3.84e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs79387448 0.745 rs1523197 chr2:103163732 A/G cg09003973 chr2:102972529 NA 0.89 8.62 0.43 2.69e-16 Gut microbiota (bacterial taxa); LUSC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg06028605 chr16:24865363 SLC5A11 -0.69 -10.81 -0.51 1.49e-23 Intelligence (multi-trait analysis); LUSC cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg01579765 chr21:45077557 HSF2BP -0.54 -11.15 -0.52 9.55e-25 Coronary artery disease; LUSC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg20203395 chr5:56204925 C5orf35 -0.54 -7.86 -0.39 5.47e-14 Coronary artery disease; LUSC cis rs2688608 0.901 rs2675671 chr10:75632760 C/T cg17411546 chr10:75410026 SYNPO2L -0.41 -5.92 -0.31 8.04e-9 Inflammatory bowel disease; LUSC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg22467129 chr15:76604101 ETFA -0.46 -7.42 -0.38 9.96e-13 Blood metabolite levels; LUSC cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg01065977 chr19:18549689 ISYNA1 -0.23 -5.93 -0.31 7.54e-9 Breast cancer; LUSC trans rs629535 0.767 rs62513418 chr8:70114376 G/T cg21567404 chr3:27674614 NA -0.97 -15.83 -0.65 1.73e-42 Dupuytren's disease; LUSC cis rs9472414 0.510 rs227844 chr6:44692212 A/C cg20913747 chr6:44695427 NA 0.42 6.15 0.32 2.27e-9 Height; LUSC trans rs10511400 0.618 rs9289143 chr3:119918661 A/C cg02809009 chr19:50354510 PTOV1 0.64 6.05 0.31 3.97e-9 Economic and political preferences (feminism/equality); LUSC cis rs4654899 0.865 rs72973154 chr1:21459125 G/T cg02927042 chr1:21476669 EIF4G3 -0.41 -6.61 -0.34 1.56e-10 Superior frontal gyrus grey matter volume; LUSC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg00944433 chr1:107599041 PRMT6 -0.38 -7.07 -0.36 9.07e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.29e-12 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg22875332 chr1:76189707 ACADM 0.82 14.39 0.62 7.5e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7267979 0.966 rs6050567 chr20:25354561 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.43 -0.33 4.36e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg20283391 chr11:68216788 NA -0.54 -8.15 -0.41 7.55e-15 Total body bone mineral density; LUSC cis rs17095355 1.000 rs12570423 chr10:111690942 C/T cg00817464 chr10:111662876 XPNPEP1 -0.56 -6.81 -0.35 4.65e-11 Biliary atresia; LUSC cis rs96067 0.772 rs2231318 chr1:36602943 C/T cg24686825 chr1:36642396 MAP7D1 -0.56 -7.57 -0.38 3.57e-13 Corneal structure; LUSC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg20891283 chr12:69753455 YEATS4 0.67 10.68 0.5 4.2e-23 Blood protein levels; LUSC cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.38 -0.42 1.5e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg16405210 chr4:1374714 KIAA1530 -0.85 -14.01 -0.61 2.07e-35 Longevity; LUSC cis rs1801251 1.000 rs1044480 chr2:233633736 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.42 0.33 4.67e-10 Coronary artery disease; LUSC trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg03929089 chr4:120376271 NA -0.85 -12.03 -0.55 6.29e-28 Height; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg10729496 chr3:10149963 C3orf24 0.59 7.89 0.4 4.31e-14 Alzheimer's disease; LUSC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg09455208 chr3:40491958 NA -0.53 -9.73 -0.47 7.45e-20 Renal cell carcinoma; LUSC cis rs6912958 0.558 rs7741825 chr6:88327338 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -5.91 -0.31 8.26e-9 Monocyte percentage of white cells; LUSC trans rs453301 0.653 rs1045529 chr8:8890098 A/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.31 -0.33 9.04e-10 Joint mobility (Beighton score); LUSC cis rs68170813 0.559 rs78440378 chr7:106962782 C/A cg02696742 chr7:106810147 HBP1 -0.64 -9.46 -0.46 5.6e-19 Coronary artery disease; LUSC cis rs9796 0.689 rs13329537 chr15:41449211 C/G cg18705301 chr15:41695430 NDUFAF1 0.44 7.18 0.37 4.64e-12 Menopause (age at onset); LUSC cis rs34421088 0.560 rs2618434 chr8:11398865 A/G cg21775007 chr8:11205619 TDH -0.54 -8.04 -0.4 1.52e-14 Neuroticism; LUSC cis rs4380275 0.965 rs4315562 chr2:772723 A/G cg21665850 chr2:731073 NA 0.42 6.81 0.35 4.58e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs4853012 0.752 rs13413795 chr2:74349839 G/A cg20891558 chr2:74357851 NA 0.83 15.12 0.64 1.01e-39 Gestational age at birth (maternal effect); LUSC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg25019033 chr10:957182 NA -0.51 -6.35 -0.33 7.09e-10 Eosinophil percentage of granulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05210937 chr4:185655043 MLF1IP -0.43 -6.38 -0.33 6.07e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg11645453 chr3:52864694 ITIH4 0.56 13.65 0.6 5.3e-34 Schizophrenia; LUSC cis rs7927592 0.913 rs11228276 chr11:68307525 A/G cg16797656 chr11:68205561 LRP5 0.38 6.22 0.32 1.52e-9 Total body bone mineral density; LUSC cis rs11585357 0.793 rs11588418 chr1:17616445 A/G cg08277548 chr1:17600880 PADI3 -0.63 -6.51 -0.34 2.7e-10 Hair shape; LUSC cis rs240764 0.817 rs11155606 chr6:101163915 T/C cg09795085 chr6:101329169 ASCC3 -0.43 -6.26 -0.32 1.19e-9 Neuroticism; LUSC cis rs10489525 0.556 rs11102882 chr1:115612222 T/A cg01522456 chr1:115632236 TSPAN2 0.4 5.69 0.3 2.83e-8 Autism; LUSC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg03909863 chr11:638404 DRD4 -0.41 -5.69 -0.3 2.74e-8 Systemic lupus erythematosus; LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg10729496 chr3:10149963 C3orf24 0.57 7.48 0.38 6.62e-13 Alzheimer's disease; LUSC cis rs28374715 0.787 rs11856169 chr15:41547938 C/T cg18705301 chr15:41695430 NDUFAF1 -0.83 -14.19 -0.61 4.39e-36 Ulcerative colitis; LUSC cis rs793571 0.669 rs714696 chr15:58962987 C/G cg05156742 chr15:59063176 FAM63B 0.56 7.87 0.4 4.92e-14 Schizophrenia; LUSC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg23649088 chr2:200775458 C2orf69 0.54 7.39 0.37 1.2e-12 Schizophrenia; LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.63 0.47 1.61e-19 Bipolar disorder; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg24813613 chr7:1882135 MAD1L1 -0.38 -6.21 -0.32 1.56e-9 Bipolar disorder and schizophrenia; LUSC cis rs2236918 0.710 rs2488470 chr1:242019580 A/G cg17736920 chr1:242011382 EXO1 0.41 6.48 0.33 3.39e-10 Menopause (age at onset); LUSC cis rs9928842 0.771 rs2870471 chr16:75274282 A/G cg09066997 chr16:75300724 BCAR1 -0.46 -6.05 -0.31 3.91e-9 Alcoholic chronic pancreatitis; LUSC cis rs9837602 1.000 rs1021103 chr3:99603230 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 5.76 0.3 1.87e-8 Breast cancer; LUSC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg12311346 chr5:56204834 C5orf35 -0.89 -12.92 -0.58 2.98e-31 Initial pursuit acceleration; LUSC cis rs10876993 0.749 rs703832 chr12:58024626 G/C cg12615879 chr12:58013172 SLC26A10 0.28 5.81 0.3 1.49e-8 Celiac disease or Rheumatoid arthritis; LUSC cis rs35146811 0.700 rs4729579 chr7:99780282 C/G cg22906224 chr7:99728672 NA 0.48 6.68 0.34 1.03e-10 Coronary artery disease; LUSC cis rs9814567 1.000 rs9968172 chr3:134231251 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.38 0.59 5.61e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs853679 0.517 rs4713143 chr6:28106759 A/C cg06606381 chr12:133084897 FBRSL1 -0.45 -5.97 -0.31 6.07e-9 Depression; LUSC cis rs11122272 0.732 rs999010 chr1:231495316 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.27 -0.49 1.06e-21 Hemoglobin concentration; LUSC cis rs617219 0.853 rs13355606 chr5:78522359 T/C cg24856658 chr5:78533917 JMY -0.3 -5.87 -0.31 1.05e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs3960554 0.674 rs113848658 chr7:75791858 G/A cg17325771 chr7:75508891 RHBDD2 -0.42 -5.89 -0.31 9.52e-9 Eotaxin levels; LUSC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg21028142 chr17:79581711 NPLOC4 0.34 8.0 0.4 2e-14 Eye color traits; LUSC cis rs6701037 1.000 rs6702010 chr1:175123858 C/A cg00321850 chr1:175162397 KIAA0040 -0.4 -6.9 -0.35 2.55e-11 Alcohol dependence; LUSC cis rs600231 0.708 rs682845 chr11:65254201 A/G cg17120908 chr11:65337727 SSSCA1 -0.53 -9.44 -0.46 6.76e-19 Bone mineral density; LUSC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg21724239 chr8:58056113 NA 0.77 8.29 0.41 2.73e-15 Developmental language disorder (linguistic errors); LUSC cis rs612683 0.599 rs2809823 chr1:101003762 C/A cg06223162 chr1:101003688 GPR88 0.57 11.47 0.53 6.65e-26 Breast cancer; LUSC cis rs73591976 0.539 rs12446198 chr16:68125972 G/A cg05110241 chr16:68378359 PRMT7 -0.6 -6.75 -0.35 6.44e-11 HDL cholesterol; LUSC cis rs977987 0.778 rs35214308 chr16:75476088 C/T cg03315344 chr16:75512273 CHST6 0.49 9.5 0.46 4.32e-19 Dupuytren's disease; LUSC cis rs4654899 0.758 rs12078457 chr1:21397071 C/T cg01072550 chr1:21505969 NA -0.5 -7.69 -0.39 1.68e-13 Superior frontal gyrus grey matter volume; LUSC cis rs868036 1.000 rs6494694 chr15:68057142 A/C cg08079166 chr15:68083412 MAP2K5 -0.42 -8.69 -0.43 1.68e-16 Restless legs syndrome; LUSC cis rs3768617 0.510 rs3768618 chr1:183092491 C/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.94 0.51 4.97e-24 Fuchs's corneal dystrophy; LUSC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.78 8.11 0.41 9.99e-15 Initial pursuit acceleration; LUSC cis rs7927771 0.524 rs7943213 chr11:47715524 T/C cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.87e-10 Subjective well-being; LUSC trans rs7615952 0.546 rs2979338 chr3:125343126 G/T cg07211511 chr3:129823064 LOC729375 -0.53 -6.08 -0.32 3.25e-9 Blood pressure (smoking interaction); LUSC cis rs3008870 1.000 rs1925411 chr1:67370292 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.1 0.64 1.26e-39 Lymphocyte percentage of white cells; LUSC cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.43 6.94 0.36 2.04e-11 Platelet count; LUSC cis rs7124681 0.584 rs4752792 chr11:47815702 G/A cg20307385 chr11:47447363 PSMC3 -0.45 -6.69 -0.34 9.64e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.03 0.4 1.66e-14 Melanoma; LUSC cis rs459571 0.959 rs461462 chr9:136911272 C/T cg01294253 chr9:136912663 BRD3 0.36 6.34 0.33 7.25e-10 Platelet distribution width; LUSC cis rs6424115 0.830 rs2501426 chr1:24199364 G/A cg15997130 chr1:24165203 NA 0.52 8.58 0.42 3.67e-16 Immature fraction of reticulocytes; LUSC cis rs9388451 0.839 rs3757217 chr6:126069636 G/C cg05901451 chr6:126070800 HEY2 -0.96 -18.94 -0.72 7.19e-55 Brugada syndrome; LUSC cis rs11032090 1 rs11032090 chr11:4417129 A/G cg07244098 chr11:4415203 TRIM21 0.35 5.8 0.3 1.57e-8 Lung cancer; LUSC cis rs3820928 0.804 rs4675125 chr2:227802499 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.14e-13 Pulmonary function; LUSC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg23791538 chr6:167370224 RNASET2 0.41 6.45 0.33 4.03e-10 Crohn's disease; LUSC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg08470875 chr2:26401718 FAM59B -0.67 -9.08 -0.44 9.81e-18 Gut microbiome composition (summer); LUSC trans rs61931739 0.817 rs10772143 chr12:34230651 T/G cg24313572 chr1:56050060 NA -0.31 -6.43 -0.33 4.53e-10 Morning vs. evening chronotype; LUSC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg14983838 chr19:29218262 NA 0.66 9.79 0.47 4.71e-20 Methadone dose in opioid dependence; LUSC cis rs4319547 0.688 rs10847415 chr12:123144293 T/C cg05707623 chr12:122985044 ZCCHC8 -0.55 -7.29 -0.37 2.27e-12 Body mass index; LUSC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg17971929 chr21:40555470 PSMG1 0.8 14.34 0.62 1.08e-36 Cognitive function; LUSC cis rs7903847 0.642 rs10882908 chr10:99134970 T/C cg08345082 chr10:99160200 RRP12 -0.38 -7.76 -0.39 1.06e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg01689657 chr7:91764605 CYP51A1 -0.32 -5.66 -0.3 3.18e-8 Breast cancer; LUSC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg06112835 chr11:68658793 MRPL21 0.51 7.81 0.39 7.24e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg22868518 chr11:507468 RNH1 -0.65 -6.1 -0.32 2.87e-9 Body mass index; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.38 -0.42 1.45e-15 Lymphocyte counts; LUSC cis rs7903847 0.596 rs869967 chr10:99147975 T/C cg20016023 chr10:99160130 RRP12 -0.32 -7.95 -0.4 2.92e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs6964587 1.000 rs7800582 chr7:91701346 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.5e-8 Breast cancer; LUSC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.6 -8.65 -0.43 2.24e-16 Mean platelet volume; LUSC cis rs892961 1.000 rs2164449 chr17:75401190 G/A cg05865280 chr17:75406074 SEPT9 0.47 10.27 0.49 1.11e-21 Airflow obstruction; LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg08742575 chr21:47604166 C21orf56 0.41 6.13 0.32 2.41e-9 Testicular germ cell tumor; LUSC cis rs7923609 0.967 rs10761751 chr10:65154885 A/G cg01631684 chr10:65280961 REEP3 -0.4 -6.21 -0.32 1.56e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs1595825 1.000 rs73058832 chr2:198873214 G/T cg19156104 chr2:198669113 PLCL1 -0.47 -5.73 -0.3 2.22e-8 Ulcerative colitis; LUSC cis rs4919687 0.550 rs12784517 chr10:104464970 T/C cg05855489 chr10:104503620 C10orf26 0.71 11.51 0.53 4.8e-26 Colorectal cancer; LUSC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg25809561 chr17:30822961 MYO1D 0.38 6.3 0.33 9.22e-10 Schizophrenia; LUSC cis rs4947962 0.617 rs112317270 chr7:55126160 T/C cg23757825 chr7:55092271 EGFR -0.53 -6.41 -0.33 4.9e-10 Subjective response to lithium treatment; LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg16362232 chr11:430036 ANO9 0.63 8.24 0.41 3.85e-15 Body mass index; LUSC trans rs62103177 0.636 rs9958792 chr18:77627876 T/C cg05926928 chr17:57297772 GDPD1 -1.05 -11.85 -0.54 2.72e-27 Opioid sensitivity; LUSC cis rs4969178 0.965 rs12944051 chr17:76395856 C/T cg20026190 chr17:76395443 PGS1 -0.42 -7.53 -0.38 4.89e-13 HDL cholesterol levels; LUSC cis rs2274273 0.686 rs28631821 chr14:55845987 T/C cg04306507 chr14:55594613 LGALS3 0.56 12.97 0.58 1.97e-31 Protein biomarker; LUSC trans rs11039798 0.557 rs683180 chr11:48463949 A/G cg15704280 chr7:45808275 SEPT13 -0.6 -6.45 -0.33 4.02e-10 Axial length; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg11965913 chr1:205819406 PM20D1 1.05 28.06 0.84 7.22e-90 Menarche (age at onset); LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.57 7.32 0.37 1.83e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs7954584 0.583 rs10770186 chr12:122361412 A/G cg10207240 chr12:122356781 WDR66 0.44 6.19 0.32 1.72e-9 Mean corpuscular volume; LUSC cis rs16958440 0.708 rs1434528 chr18:44632323 G/A cg17192377 chr18:44677553 HDHD2 0.43 5.67 0.3 3.02e-8 Sitting height ratio; LUSC cis rs4713675 0.565 rs4711341 chr6:33690797 A/G cg14003231 chr6:33640908 ITPR3 0.29 5.7 0.3 2.59e-8 Plateletcrit; LUSC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg04865166 chr7:105162814 PUS7 0.51 5.74 0.3 2.15e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7553864 0.667 rs4656143 chr1:87605208 G/A cg17420885 chr1:87600446 LOC339524 -0.46 -6.37 -0.33 6.24e-10 Smoking behavior; LUSC cis rs12711979 0.509 rs882418 chr2:3820113 A/G cg17052675 chr2:3827356 NA -0.83 -17.72 -0.7 5.16e-50 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18099408 chr3:52552593 STAB1 -0.48 -8.56 -0.42 4.16e-16 Bipolar disorder; LUSC cis rs7241530 0.662 rs7230384 chr18:75908189 A/G cg14642773 chr18:75888474 NA 0.38 5.66 0.3 3.27e-8 Educational attainment (years of education); LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC cis rs4888262 0.526 rs7193508 chr16:74628630 G/T cg01733217 chr16:74700730 RFWD3 0.8 13.43 0.59 3.48e-33 Testicular germ cell tumor; LUSC trans rs6601327 0.641 rs7014663 chr8:9587275 G/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.47 -0.33 3.57e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs950169 0.840 rs2896002 chr15:84945121 A/G cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs3733631 0.948 rs3733632 chr4:104640935 A/G cg24090629 chr4:104641072 TACR3 -0.5 -6.44 -0.33 4.17e-10 Menarche (age at onset); LUSC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg13114125 chr14:105738426 BRF1 -0.92 -15.77 -0.65 2.85e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg00684032 chr4:1343700 KIAA1530 0.44 7.76 0.39 1.06e-13 Obesity-related traits; LUSC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg11247378 chr22:39784982 NA -0.67 -13.64 -0.6 5.67e-34 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.47 -6.4 -0.33 5.14e-10 Renal function-related traits (BUN); LUSC cis rs16866061 0.855 rs11687736 chr2:225405122 A/T cg12698349 chr2:225449008 CUL3 0.87 14.37 0.62 8.48e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs7202877 0.706 rs37605 chr16:75506572 G/C cg04384234 chr16:75411784 CFDP1 0.66 9.01 0.44 1.61e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6087990 0.899 rs6087999 chr20:31363774 A/G cg13636640 chr20:31349939 DNMT3B 0.99 22.58 0.78 3.34e-69 Ulcerative colitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12035827 chr1:10855226 CASZ1 -0.51 -6.7 -0.34 8.78e-11 Bipolar disorder and schizophrenia; LUSC cis rs4356932 1.000 rs3921 chr4:76942943 C/G cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.29e-8 Blood protein levels; LUSC cis rs3126085 0.935 rs1496050 chr1:152163549 T/C cg26876637 chr1:152193138 HRNR 0.47 6.62 0.34 1.47e-10 Atopic dermatitis; LUSC cis rs7582180 0.629 rs4851295 chr2:100945605 T/C cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7633770 0.710 rs4683259 chr3:46698538 A/G cg11219411 chr3:46661640 NA -0.29 -5.72 -0.3 2.31e-8 Coronary artery disease; LUSC trans rs61931739 0.857 rs999715 chr12:34143253 G/C cg13010199 chr12:38710504 ALG10B 0.43 6.85 0.35 3.59e-11 Morning vs. evening chronotype; LUSC cis rs3737883 1.000 rs2270543 chr1:203030685 T/C cg00805880 chr1:203045044 PPFIA4 -0.28 -5.76 -0.3 1.88e-8 Early onset atrial fibrillation; LUSC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg09650180 chr20:62225654 GMEB2 -0.67 -9.74 -0.47 6.68e-20 Glioblastoma; LUSC cis rs4481887 0.676 rs946764 chr1:248522033 A/C cg26353448 chr1:248524236 OR2T4 -0.33 -6.27 -0.32 1.12e-9 Common traits (Other); LUSC cis rs7605378 1.000 rs769958 chr2:200695901 G/A cg23649088 chr2:200775458 C2orf69 0.53 8.18 0.41 5.92e-15 Osteoporosis; LUSC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg21918786 chr6:109611834 NA -0.4 -7.07 -0.36 9.06e-12 Reticulocyte fraction of red cells; LUSC cis rs9527 0.615 rs3897401 chr10:104696379 T/C cg08330031 chr10:104623503 C10orf32 0.31 5.64 0.3 3.54e-8 Arsenic metabolism; LUSC cis rs6066835 1.000 rs6063311 chr20:47325315 C/T cg18078177 chr20:47281410 PREX1 0.75 6.1 0.32 2.87e-9 Multiple myeloma; LUSC cis rs3540 0.512 rs3862437 chr15:91084632 A/G cg22089800 chr15:90895588 ZNF774 -0.63 -9.47 -0.46 5.25e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg15242686 chr22:24348715 GSTTP1 0.44 6.52 0.34 2.61e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11098499 0.954 rs10006525 chr4:120408931 T/G cg25214090 chr10:38739885 LOC399744 0.53 7.85 0.39 5.88e-14 Corneal astigmatism; LUSC trans rs911555 0.504 rs745079 chr14:104073551 G/A cg03785828 chr5:81573306 RPS23 -0.37 -6.02 -0.31 4.56e-9 Intelligence (multi-trait analysis); LUSC cis rs7000551 0.689 rs6993341 chr8:22310933 T/C cg12081754 chr8:22256438 SLC39A14 0.45 6.89 0.35 2.72e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2180341 0.596 rs12215298 chr6:127676833 C/T cg24812749 chr6:127587940 RNF146 0.73 11.04 0.52 2.24e-24 Breast cancer; LUSC cis rs10761482 0.564 rs10733765 chr10:62237399 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.38 -0.33 5.9e-10 Schizophrenia; LUSC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg03116740 chr11:841335 TSPAN4;POLR2L -0.43 -7.06 -0.36 9.49e-12 Mean platelet volume; LUSC cis rs61931739 0.635 rs1486883 chr12:33908740 C/T cg06521331 chr12:34319734 NA -0.4 -6.54 -0.34 2.29e-10 Morning vs. evening chronotype; LUSC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg11062466 chr8:58055876 NA 0.78 13.32 0.59 8.93e-33 Developmental language disorder (linguistic errors); LUSC trans rs9929218 0.906 rs9933844 chr16:68747001 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -12.08 -0.55 3.88e-28 Colorectal cancer; LUSC cis rs11971779 0.793 rs11764426 chr7:139024050 C/G cg07862535 chr7:139043722 LUC7L2 0.59 7.12 0.36 6.49e-12 Diisocyanate-induced asthma; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.45 0.42 8.8e-16 Prudent dietary pattern; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01949902 chr22:40440554 TNRC6B 0.71 5.97 0.31 6.04e-9 Cognitive performance; LUSC cis rs9325144 0.541 rs7303395 chr12:38664124 C/T cg13010199 chr12:38710504 ALG10B -0.51 -7.67 -0.39 1.87e-13 Morning vs. evening chronotype; LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg27094323 chr7:1216898 NA -0.44 -7.43 -0.38 9.04e-13 Longevity;Endometriosis; LUSC cis rs56283067 0.887 rs12198016 chr6:44771708 C/T cg20913747 chr6:44695427 NA -0.47 -7.23 -0.37 3.35e-12 Total body bone mineral density; LUSC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg20607287 chr7:12443886 VWDE -0.61 -6.43 -0.33 4.45e-10 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17619082 chr7:43768796 C7orf44 -0.54 -7.17 -0.37 4.85e-12 Bipolar disorder and schizophrenia; LUSC trans rs2898290 0.622 rs4840567 chr8:11347625 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.62 -0.43 2.68e-16 Systolic blood pressure; LUSC cis rs10782582 0.593 rs12142247 chr1:76235746 C/T cg22875332 chr1:76189707 ACADM -0.39 -5.86 -0.31 1.1e-8 Daytime sleep phenotypes; LUSC cis rs8180040 1.000 rs295428 chr3:47359262 G/T cg16586182 chr3:47516702 SCAP -0.48 -7.46 -0.38 7.78e-13 Colorectal cancer; LUSC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg12463550 chr7:65579703 CRCP 0.44 6.5 0.33 3.01e-10 Aortic root size; LUSC cis rs1878931 0.517 rs17685105 chr16:3413749 C/T cg00484396 chr16:3507460 NAT15 0.41 6.62 0.34 1.4e-10 Body mass index (adult); LUSC cis rs9354352 0.935 rs7766730 chr6:66697003 C/A cg07460842 chr6:66804631 NA 0.68 9.95 0.48 1.33e-20 Initial pursuit acceleration in psychotic disorders; LUSC cis rs2760061 0.626 rs2527615 chr1:228119283 A/G cg02753203 chr1:228287806 NA -0.67 -11.48 -0.53 6.14e-26 Diastolic blood pressure; LUSC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg14983838 chr19:29218262 NA 0.65 8.85 0.44 5.33e-17 Methadone dose in opioid dependence; LUSC cis rs3892630 0.588 rs7260037 chr19:33242701 G/A cg22980127 chr19:33182716 NUDT19 0.9 12.86 0.58 5.17e-31 Red blood cell traits; LUSC cis rs1322512 1.000 rs2758780 chr6:153008108 A/G cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs3741151 0.686 rs12276892 chr11:73283990 A/T cg17517138 chr11:73019481 ARHGEF17 0.78 7.43 0.38 9.07e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1185460 0.967 rs1168568 chr11:118949799 G/A cg01677386 chr11:118938358 VPS11 -0.49 -6.9 -0.35 2.61e-11 Coronary artery disease; LUSC cis rs2275620 1.000 rs7910936 chr10:96804451 C/T cg09036531 chr10:96991505 NA -0.39 -5.68 -0.3 2.95e-8 Gout; LUSC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.54 -6.9 -0.35 2.62e-11 Schizophrenia; LUSC cis rs73416724 1.000 rs70953670 chr6:43264895 C/A cg26312998 chr6:43337775 ZNF318 0.56 6.32 0.33 8.29e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs10782582 0.545 rs111927462 chr1:76195422 A/G cg10523679 chr1:76189770 ACADM -0.5 -7.11 -0.36 7.15e-12 Daytime sleep phenotypes; LUSC cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg10978503 chr1:24200527 CNR2 -0.47 -11.21 -0.52 5.48e-25 Immature fraction of reticulocytes; LUSC cis rs7107174 0.688 rs881361 chr11:78128047 C/G cg27205649 chr11:78285834 NARS2 -0.51 -5.87 -0.31 1.05e-8 Testicular germ cell tumor; LUSC cis rs7267979 1.000 rs6050598 chr20:25397257 C/G cg03522245 chr20:25566470 NINL 0.35 5.79 0.3 1.59e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3925075 1.000 rs4506917 chr16:31347350 T/G cg02846316 chr16:31340340 ITGAM 0.36 6.66 0.34 1.11e-10 IgA nephropathy; LUSC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg26116260 chr4:7069785 GRPEL1 1.16 18.16 0.7 9.53e-52 Monocyte percentage of white cells; LUSC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg19622623 chr12:86230825 RASSF9 -0.44 -6.33 -0.33 7.94e-10 Major depressive disorder; LUSC cis rs9733 0.621 rs932054 chr1:150539867 C/G cg13175981 chr1:150552382 MCL1 0.48 6.55 0.34 2.16e-10 Tonsillectomy; LUSC cis rs12464559 0.522 rs4664498 chr2:152575417 A/G cg01189475 chr2:152685088 ARL5A 0.64 6.79 0.35 5.27e-11 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg01884057 chr2:25150051 NA 0.48 11.43 0.53 9.67e-26 Body mass index; LUSC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg18479299 chr3:125709523 NA -0.51 -5.92 -0.31 8.12e-9 Blood pressure (smoking interaction); LUSC trans rs7613875 0.620 rs13079006 chr3:49996924 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.5 7.98 0.4 2.41e-14 Body mass index; LUSC cis rs2625529 0.590 rs2856929 chr15:72496762 T/C cg16672083 chr15:72433130 SENP8 -0.49 -7.29 -0.37 2.31e-12 Red blood cell count; LUSC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg16797656 chr11:68205561 LRP5 -0.4 -7.06 -0.36 9.87e-12 Total body bone mineral density; LUSC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg06618935 chr21:46677482 NA 0.38 7.65 0.39 2.17e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs367615 0.550 rs10060801 chr5:108881782 A/G cg17395555 chr5:108820864 NA 0.43 8.04 0.4 1.54e-14 Colorectal cancer (SNP x SNP interaction); LUSC cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg17211192 chr8:82754475 SNX16 0.77 10.41 0.49 3.7e-22 Diastolic blood pressure; LUSC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg11279151 chr3:101281821 RG9MTD1 -0.48 -7.64 -0.39 2.24e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2625529 0.824 rs12916694 chr15:72298140 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.44 -0.38 8.7e-13 Red blood cell count; LUSC cis rs6496667 0.533 rs7173201 chr15:90991195 A/T cg10434728 chr15:90938212 IQGAP1 0.33 6.2 0.32 1.63e-9 Rheumatoid arthritis; LUSC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg03929089 chr4:120376271 NA -0.97 -16.69 -0.67 6.59e-46 Coronary artery disease; LUSC cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg27129171 chr3:47204927 SETD2 -0.67 -10.94 -0.51 4.98e-24 Colorectal cancer; LUSC cis rs9814567 1.000 rs13096604 chr3:134250099 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.88 0.6 6.88e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2479724 0.591 rs2479723 chr6:41890835 G/A cg17623882 chr6:41773611 USP49 -0.48 -6.33 -0.33 7.87e-10 Menarche (age at onset); LUSC cis rs2692947 0.770 rs2579552 chr2:96737083 A/G cg23100626 chr2:96804247 ASTL 0.32 7.58 0.38 3.5e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4423214 0.798 rs12224205 chr11:71180992 A/G cg05163923 chr11:71159392 DHCR7 -0.77 -10.28 -0.49 1e-21 Vitamin D levels; LUSC cis rs9341808 0.727 rs9352809 chr6:80999316 C/T cg08355045 chr6:80787529 NA 0.56 9.8 0.47 4.14e-20 Sitting height ratio; LUSC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg17747265 chr1:1875780 NA 0.64 13.6 0.6 8.03e-34 Body mass index; LUSC cis rs10992471 0.603 rs10820974 chr9:95211876 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.24 -0.32 1.35e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4363385 0.818 rs451939 chr1:153006877 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.44e-8 Inflammatory skin disease; LUSC cis rs9300255 0.602 rs1790095 chr12:123681222 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.32 -0.33 8.29e-10 Neutrophil percentage of white cells; LUSC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg02569458 chr12:86230093 RASSF9 0.58 9.96 0.48 1.26e-20 Major depressive disorder; LUSC trans rs2243480 0.708 rs35310401 chr7:65390359 A/G cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs7107174 0.748 rs2063730 chr11:78048524 A/C cg02023728 chr11:77925099 USP35 0.39 5.93 0.31 7.42e-9 Testicular germ cell tumor; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.64 -0.34 1.24e-10 Bipolar disorder and schizophrenia; LUSC cis rs709400 0.663 rs72708893 chr14:103929535 G/A cg12935359 chr14:103987150 CKB -0.57 -8.83 -0.44 5.97e-17 Body mass index; LUSC cis rs3617 0.573 rs56383738 chr3:52908398 T/C cg18404041 chr3:52824283 ITIH1 0.41 6.92 0.35 2.38e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg03396347 chr1:1875803 NA 0.54 12.15 0.55 2.31e-28 Body mass index; LUSC cis rs59698941 0.943 rs67268447 chr5:132303194 G/A cg02081065 chr5:132209139 LEAP2 -0.61 -5.87 -0.31 1.03e-8 Apolipoprotein A-IV levels; LUSC cis rs9297145 0.585 rs10953283 chr7:98782750 A/G cg05967295 chr7:98741636 SMURF1 0.61 9.31 0.45 1.71e-18 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs13006833 0.635 rs2664251 chr2:191147667 C/T cg21644426 chr2:191273491 MFSD6 0.47 6.76 0.35 6.15e-11 Urinary metabolites; LUSC cis rs921665 0.831 rs4337500 chr2:3190786 T/C cg16434511 chr2:3151078 NA -0.63 -6.82 -0.35 4.22e-11 World class endurance athleticism; LUSC cis rs12421382 0.614 rs12420249 chr11:109390254 T/G cg11473876 chr11:109292803 C11orf87 0.34 5.72 0.3 2.4e-8 Schizophrenia; LUSC cis rs10979 1.000 rs10979 chr6:143890039 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 5.94 0.31 7.34e-9 Lymphocyte counts; LUSC cis rs7106204 0.764 rs4508205 chr11:24218850 C/T ch.11.24196551F chr11:24239977 NA 0.93 9.49 0.46 4.68e-19 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg04267008 chr7:1944627 MAD1L1 0.42 6.17 0.32 1.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -14.05 -0.61 1.5e-35 Hemoglobin concentration; LUSC cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg09165964 chr15:75287851 SCAMP5 0.5 7.37 0.37 1.31e-12 Breast cancer; LUSC cis rs13082711 0.871 rs7624790 chr3:27468601 C/A cg02860705 chr3:27208620 NA 0.5 8.41 0.42 1.2e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.72 -7.39 -0.37 1.21e-12 Initial pursuit acceleration; LUSC cis rs35146811 0.657 rs36019559 chr7:99814586 A/G cg22906224 chr7:99728672 NA -0.47 -6.55 -0.34 2.15e-10 Coronary artery disease; LUSC trans rs1325195 0.920 rs2793803 chr1:179201438 A/C cg11624085 chr17:8464688 MYH10 0.41 6.69 0.34 9.35e-11 IgE grass sensitization; LUSC trans rs1997103 0.863 rs4480062 chr7:55401299 T/C cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg13939156 chr17:80058883 NA 0.33 6.52 0.34 2.59e-10 Life satisfaction; LUSC cis rs2274273 0.870 rs4597235 chr14:55851987 A/G cg04306507 chr14:55594613 LGALS3 0.56 12.83 0.57 6.51e-31 Protein biomarker; LUSC cis rs12594515 1.000 rs8033148 chr15:45997929 G/A cg01629716 chr15:45996671 NA 0.4 5.96 0.31 6.25e-9 Waist circumference;Weight; LUSC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg11764359 chr7:65958608 NA -0.68 -10.39 -0.49 4.22e-22 Aortic root size; LUSC cis rs8025790 0.508 rs4776370 chr15:67904511 T/C cg24579218 chr15:68104479 NA -0.37 -6.16 -0.32 2.1e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs4919694 1.000 rs17787717 chr10:104695699 T/G cg04362960 chr10:104952993 NT5C2 1.17 13.94 0.61 4.04e-35 Arsenic metabolism; LUSC cis rs73198271 0.641 rs34473848 chr8:8649837 C/T cg01851573 chr8:8652454 MFHAS1 0.53 8.51 0.42 5.95e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg05347473 chr6:146136440 FBXO30 -0.56 -9.78 -0.47 4.91e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs12190007 0.547 rs2981945 chr6:169819839 G/A cg15038512 chr6:170123185 PHF10 -0.38 -6.18 -0.32 1.84e-9 Obesity-related traits; LUSC cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg16230307 chr14:35515116 FAM177A1 0.79 10.04 0.48 6.44e-21 Psoriasis; LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg24829409 chr8:58192753 C8orf71 -0.48 -5.78 -0.3 1.73e-8 Developmental language disorder (linguistic errors); LUSC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs921665 0.831 rs12476669 chr2:3195428 A/T cg16434511 chr2:3151078 NA -0.74 -7.56 -0.38 3.87e-13 World class endurance athleticism; LUSC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg06022373 chr22:39101656 GTPBP1 0.84 14.01 0.61 2.07e-35 Menopause (age at onset); LUSC cis rs1941023 0.503 rs4939349 chr11:60135880 G/A cg08716584 chr11:60157161 MS4A7 -0.62 -11.64 -0.54 1.63e-26 Congenital heart disease (maternal effect); LUSC cis rs921968 1.000 rs921968 chr2:219272294 G/T cg02176678 chr2:219576539 TTLL4 0.5 8.43 0.42 1.03e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs9902453 0.845 rs2321493 chr17:28230359 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 10.06 0.48 5.89e-21 Coffee consumption (cups per day); LUSC trans rs208520 0.874 rs208491 chr6:66928459 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -13.91 -0.61 5.22e-35 Exhaled nitric oxide output; LUSC cis rs11690935 0.959 rs7608403 chr2:172646765 A/C cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.93 -0.63 5.62e-39 Schizophrenia; LUSC cis rs7103648 0.695 rs10838726 chr11:47568344 C/G cg20307385 chr11:47447363 PSMC3 0.87 13.93 0.61 4.29e-35 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.39 -0.37 1.22e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg15445000 chr17:37608096 MED1 -0.38 -6.55 -0.34 2.15e-10 Glomerular filtration rate (creatinine); LUSC cis rs3784262 1.000 rs12908953 chr15:58277812 A/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.78 -0.3 1.68e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs6951245 0.678 rs28600085 chr7:1169636 C/T cg13565492 chr6:43139072 SRF -0.61 -7.02 -0.36 1.25e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6484504 0.576 rs2447671 chr11:31334323 A/G cg06552810 chr11:31128660 NA -0.36 -6.33 -0.33 7.88e-10 Red blood cell count; LUSC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.61 7.54 0.38 4.61e-13 Lung function (FEV1/FVC); LUSC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -8.26 -0.41 3.51e-15 Personality dimensions; LUSC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg20891283 chr12:69753455 YEATS4 0.93 17.88 0.7 1.24e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs12122100 0.913 rs35811591 chr1:146515238 C/T cg03526459 chr1:146549940 NA -0.4 -6.47 -0.33 3.56e-10 HIV-1 control; LUSC trans rs71435601 0.628 rs494465 chr2:21401010 C/T cg20757404 chr19:378427 NA 0.37 5.96 0.31 6.28e-9 Cholesterol, total; LUSC cis rs7819412 0.645 rs10156356 chr8:11046209 T/C cg21775007 chr8:11205619 TDH -0.49 -6.81 -0.35 4.65e-11 Triglycerides; LUSC cis rs3743266 0.613 rs4775273 chr15:60738566 T/G cg21667061 chr15:60772094 NARG2 -0.37 -6.2 -0.32 1.63e-9 Menarche (age at onset); LUSC cis rs7100689 0.599 rs7077847 chr10:82134952 A/G cg00277334 chr10:82204260 NA -0.5 -7.26 -0.37 2.8e-12 Post bronchodilator FEV1; LUSC cis rs7937682 0.924 rs875257 chr11:111530453 A/G cg09085632 chr11:111637200 PPP2R1B -1.1 -17.98 -0.7 4.8e-51 Primary sclerosing cholangitis; LUSC cis rs2290416 0.892 rs3793369 chr8:144664335 G/A cg26536354 chr8:144654954 C8orf73 0.64 7.34 0.37 1.63e-12 Attention deficit hyperactivity disorder; LUSC cis rs868036 0.681 rs4776978 chr15:68108305 A/G cg05925327 chr15:68127851 NA -0.41 -6.46 -0.33 3.79e-10 Restless legs syndrome; LUSC cis rs7659604 0.540 rs116452657 chr4:122674147 A/G cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs559928 0.556 rs11607903 chr11:63932140 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.25 0.37 2.93e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg17173187 chr15:85201210 NMB -0.32 -6.37 -0.33 6.2e-10 P wave terminal force; LUSC cis rs11642862 0.792 rs75586365 chr16:30996363 C/T cg02466173 chr16:30829666 NA -0.61 -6.47 -0.33 3.42e-10 Tonsillectomy; LUSC trans rs7819412 0.668 rs4841507 chr8:11046394 C/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.93 -0.35 2.14e-11 Triglycerides; LUSC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg26335602 chr6:28129616 ZNF389 0.43 5.75 0.3 1.98e-8 Depression; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18404009 chr19:33667550 NA 0.77 6.13 0.32 2.51e-9 Cognitive performance; LUSC trans rs11098499 0.738 rs28408407 chr4:120376030 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.31 0.33 9.12e-10 Corneal astigmatism; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg12419862 chr22:24373484 LOC391322 -0.87 -14.22 -0.61 3.27e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg04352962 chr1:209979756 IRF6 0.55 6.46 0.33 3.73e-10 Cleft lip with or without cleft palate; LUSC cis rs12220238 0.908 rs11000937 chr10:75998785 A/C cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.03 0.36 1.17e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs8031584 1.000 rs35607976 chr15:31277788 T/C cg14829155 chr15:31115871 NA -0.64 -8.72 -0.43 1.29e-16 Huntington's disease progression; LUSC cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.4 -6.84 -0.35 3.75e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg11584989 chr19:19387371 SF4 -0.55 -6.31 -0.33 8.61e-10 Bipolar disorder; LUSC cis rs909341 0.868 rs6089961 chr20:62349491 G/A cg09650180 chr20:62225654 GMEB2 -0.46 -6.09 -0.32 3.09e-9 Atopic dermatitis; LUSC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.78 0.3 1.7e-8 Menopause (age at onset); LUSC cis rs6598955 0.543 rs17163720 chr1:26549399 A/G cg04990556 chr1:26633338 UBXN11 -0.87 -11.52 -0.53 4.55e-26 Obesity-related traits; LUSC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg21951975 chr1:209979733 IRF6 0.41 6.8 0.35 4.89e-11 Monobrow; LUSC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs6961069 0.743 rs1358337 chr7:80288385 C/T cg04458919 chr7:80252533 CD36 -0.34 -6.06 -0.31 3.59e-9 Platelet count; LUSC trans rs1814175 0.541 rs12287397 chr11:49819799 G/A cg03929089 chr4:120376271 NA -1.04 -19.93 -0.74 9.13e-59 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09181473 chr12:93836052 UBE2N -0.42 -6.35 -0.33 7.05e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18061532 chr13:25086879 PARP4 0.72 6.48 0.33 3.3e-10 Cognitive performance; LUSC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg06637938 chr14:75390232 RPS6KL1 0.51 8.33 0.41 2.07e-15 Height; LUSC cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg20283391 chr11:68216788 NA -0.57 -8.05 -0.4 1.44e-14 Total body bone mineral density; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.19 0.76 9.28e-64 Prudent dietary pattern; LUSC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg04362960 chr10:104952993 NT5C2 0.58 9.3 0.45 1.9e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs4596713 0.538 rs7865373 chr9:71765105 T/C cg25283916 chr1:242222868 NA -0.32 -6.57 -0.34 1.89e-10 Headache; LUSC cis rs3768617 0.510 rs4491025 chr1:183065183 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.71 0.51 3.22e-23 Fuchs's corneal dystrophy; LUSC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg16049864 chr8:95962084 TP53INP1 -0.51 -9.22 -0.45 3.54e-18 Type 2 diabetes; LUSC cis rs8077577 0.895 rs1563373 chr17:18114228 G/A cg16794390 chr17:18148240 FLII 0.41 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs8018808 0.935 rs17824034 chr14:77878683 A/G cg20045696 chr14:77926864 AHSA1 0.35 5.75 0.3 1.99e-8 Myeloid white cell count; LUSC trans rs7818345 0.624 rs12682196 chr8:19332963 A/C cg07611933 chr16:2773245 NA 0.23 6.03 0.31 4.43e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg26597838 chr10:835615 NA 0.8 10.92 0.51 6.11e-24 Eosinophil percentage of granulocytes; LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg11062466 chr8:58055876 NA 0.71 8.73 0.43 1.27e-16 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg27121462 chr16:89883253 FANCA 0.56 8.95 0.44 2.48e-17 Vitiligo; LUSC trans rs1005277 0.579 rs2472176 chr10:38382921 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.57 -0.46 2.51e-19 Extrinsic epigenetic age acceleration; LUSC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC cis rs6952809 0.590 rs1468337 chr7:2432211 C/T cg23289794 chr7:2394357 EIF3B -0.7 -9.39 -0.46 9.64e-19 Multiple sclerosis; LUSC cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg15997130 chr1:24165203 NA -0.47 -6.98 -0.36 1.56e-11 Immature fraction of reticulocytes; LUSC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg24675056 chr1:15929824 NA 0.43 7.41 0.38 1.03e-12 Systolic blood pressure; LUSC cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg08999081 chr20:33150536 PIGU -0.53 -10.52 -0.5 1.52e-22 Glomerular filtration rate (creatinine); LUSC cis rs9379945 1 rs9379945 chr6:26907831 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.48 -5.89 -0.31 9.51e-9 Intelligence (multi-trait analysis); LUSC trans rs12145833 0.596 rs12134228 chr1:243447618 C/T cg01826367 chr1:224180288 NA 0.63 5.95 0.31 6.62e-9 Obesity (early onset extreme); LUSC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs3818285 0.632 rs536343 chr10:111632879 T/C cg00817464 chr10:111662876 XPNPEP1 0.71 12.54 0.57 7.86e-30 Superior crus of antihelix expression; LUSC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg04511125 chr2:88470314 THNSL2 0.97 9.55 0.46 2.87e-19 Plasma clusterin levels; LUSC cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs10752881 1.000 rs10911191 chr1:182984524 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 10.24 0.49 1.4e-21 Colorectal cancer; LUSC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg14558114 chr2:88469736 THNSL2 0.76 6.66 0.34 1.15e-10 Plasma clusterin levels; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg05665937 chr4:1216051 CTBP1 -0.37 -5.78 -0.3 1.69e-8 Obesity-related traits; LUSC cis rs2637266 0.783 rs4980006 chr10:78477993 G/C cg18941641 chr10:78392320 NA 0.34 6.21 0.32 1.56e-9 Pulmonary function; LUSC cis rs9640161 0.830 rs11768108 chr7:150064150 C/T cg10018233 chr7:150070692 REPIN1 0.41 7.2 0.37 3.99e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs9388451 0.872 rs2008027 chr6:126052359 A/G cg05901451 chr6:126070800 HEY2 -0.93 -18.12 -0.7 1.34e-51 Brugada syndrome; LUSC cis rs1982963 1.000 rs2029975 chr14:52506070 C/T cg10843707 chr14:52510701 NID2 -0.4 -6.45 -0.33 3.99e-10 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs629535 0.862 rs2178955 chr8:70045303 C/T cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs9457247 0.534 rs12055488 chr6:167379570 A/G cg25258033 chr6:167368657 RNASET2 -0.36 -5.68 -0.3 2.99e-8 Crohn's disease; LUSC cis rs8060686 0.668 rs9932414 chr16:68219969 A/G cg05110241 chr16:68378359 PRMT7 -0.44 -5.78 -0.3 1.72e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs5769707 0.616 rs6009786 chr22:50015145 A/G cg05373962 chr22:49881684 NA -0.41 -8.59 -0.43 3.46e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg10645314 chr2:3704589 ALLC -0.37 -6.64 -0.34 1.27e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2658782 0.789 rs2605574 chr11:93136444 T/G cg15737290 chr11:93063684 CCDC67 0.64 8.15 0.41 7.32e-15 Pulmonary function decline; LUSC cis rs11229555 0.609 rs34782543 chr11:58187398 G/A cg15696309 chr11:58395628 NA -0.64 -7.78 -0.39 9.19e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs597583 0.806 rs11605509 chr11:117396433 T/C cg27161313 chr11:117392002 DSCAML1 -0.43 -7.19 -0.37 4.33e-12 Putamen volume; LUSC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg07701084 chr6:150067640 NUP43 0.5 7.43 0.38 8.98e-13 Lung cancer; LUSC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg02569458 chr12:86230093 RASSF9 0.54 9.21 0.45 3.78e-18 Major depressive disorder; LUSC cis rs7208859 0.623 rs11658022 chr17:29085359 A/T cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9303401 0.555 rs8073699 chr17:57236317 G/A cg25039879 chr17:56429692 SUPT4H1 0.42 6.0 0.31 5.16e-9 Cognitive test performance; LUSC cis rs78523330 0.614 rs78443405 chr17:37072073 G/A cg21637561 chr17:37074902 LASP1 -0.62 -5.9 -0.31 8.92e-9 Multiple system atrophy; LUSC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg07701084 chr6:150067640 NUP43 0.56 8.38 0.42 1.47e-15 Lung cancer; LUSC cis rs701145 0.556 rs357502 chr3:153955950 C/T cg10247383 chr3:153839028 SGEF -0.51 -6.19 -0.32 1.74e-9 Coronary artery disease; LUSC cis rs1878931 0.582 rs9635562 chr16:3416689 G/A cg22508957 chr16:3507546 NAT15 -0.41 -5.8 -0.3 1.54e-8 Body mass index (adult); LUSC cis rs3020736 0.500 rs2413669 chr22:42507748 A/C cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs10751667 0.666 rs7395402 chr11:950293 A/G ch.11.42038R chr11:967971 AP2A2 -0.42 -6.34 -0.33 7.35e-10 Alzheimer's disease (late onset); LUSC cis rs394563 0.591 rs237016 chr6:149744859 T/C cg03678062 chr6:149772716 ZC3H12D -0.3 -6.16 -0.32 2.11e-9 Dupuytren's disease; LUSC cis rs7647973 0.961 rs4955430 chr3:49378088 G/A cg07636037 chr3:49044803 WDR6 0.67 8.78 0.43 8.93e-17 Menarche (age at onset); LUSC cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg01689657 chr7:91764605 CYP51A1 -0.34 -6.18 -0.32 1.84e-9 Breast cancer; LUSC cis rs2115630 1.000 rs1030863 chr15:85282635 C/T cg09876464 chr15:85330779 ZNF592 0.36 6.66 0.34 1.14e-10 P wave terminal force; LUSC cis rs1538970 0.924 rs6657284 chr1:45879088 T/C cg05343316 chr1:45956843 TESK2 0.63 8.73 0.43 1.2e-16 Platelet count; LUSC cis rs6088813 0.922 rs6088800 chr20:33934437 T/A cg14752227 chr20:34000481 UQCC -0.36 -5.65 -0.3 3.4e-8 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22077701 chr4:144434441 SMARCA5 -0.46 -6.73 -0.35 7.28e-11 Electrocardiographic conduction measures; LUSC cis rs12760731 0.565 rs116253445 chr1:178216962 C/T cg00404053 chr1:178313656 RASAL2 0.67 6.92 0.35 2.33e-11 Obesity-related traits; LUSC cis rs1322512 0.883 rs2758814 chr6:152966367 C/T cg27316956 chr6:152958899 SYNE1 -0.34 -5.87 -0.31 1.04e-8 Tonometry; LUSC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11890956 chr21:40555474 PSMG1 1.03 20.49 0.75 5.09e-61 Cognitive function; LUSC cis rs12549902 1.000 rs12550613 chr8:41510260 G/C cg21772509 chr8:41503840 NKX6-3 0.67 11.22 0.52 5.34e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs2599510 0.807 rs176416 chr2:32652223 A/G cg02381751 chr2:32503542 YIPF4 -0.4 -5.83 -0.3 1.27e-8 Interleukin-18 levels; LUSC cis rs68170813 0.652 rs4730250 chr7:107207695 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.48 -5.89 -0.31 9.58e-9 Coronary artery disease; LUSC cis rs4654899 0.601 rs6668094 chr1:21464387 C/T cg01072550 chr1:21505969 NA 0.5 7.51 0.38 5.5e-13 Superior frontal gyrus grey matter volume; LUSC cis rs10754283 0.557 rs1215511 chr1:90087543 C/A cg21401794 chr1:90099060 LRRC8C 0.53 7.39 0.37 1.21e-12 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2832077 0.689 rs2832052 chr21:30130073 G/C cg24692254 chr21:30365293 RNF160 -0.63 -8.6 -0.43 3.16e-16 Cognitive test performance; LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg02018176 chr4:1364513 KIAA1530 0.52 8.83 0.43 6.21e-17 Obesity-related traits; LUSC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg10169327 chr19:45448959 APOC2 -0.29 -6.03 -0.31 4.42e-9 Blood protein levels; LUSC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg06637938 chr14:75390232 RPS6KL1 -0.47 -7.35 -0.37 1.56e-12 Height; LUSC cis rs3791556 0.842 rs55840142 chr2:240106884 G/A cg03281426 chr2:240109471 HDAC4 0.52 7.15 0.36 5.53e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11971779 0.564 rs6467841 chr7:139066092 T/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2629540 1.000 rs2629540 chr10:126426148 G/C cg08799069 chr10:126477246 METTL10 0.67 9.18 0.45 4.74e-18 Cocaine dependence; LUSC cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg00049323 chr5:472564 LOC25845 0.49 7.72 0.39 1.33e-13 Cystic fibrosis severity; LUSC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg11742103 chr11:62369870 EML3;MTA2 -0.48 -7.3 -0.37 2.18e-12 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs698813 0.851 rs698807 chr2:44701659 G/C cg00619915 chr2:44497795 NA -0.41 -5.92 -0.31 8.12e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs6001027 0.517 rs2284060 chr22:38543453 A/G cg25457927 chr22:38595422 NA -0.3 -6.01 -0.31 4.94e-9 Melanoma; LUSC trans rs4650994 0.525 rs2811295 chr1:178551267 C/T cg05059571 chr16:84539110 KIAA1609 0.48 9.35 0.46 1.35e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs11098499 0.954 rs10034623 chr4:120397829 G/A cg24375607 chr4:120327624 NA 0.8 12.13 0.55 2.66e-28 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21450137 chr2:25016479 C2orf79;CENPO -0.42 -6.27 -0.32 1.09e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg21918786 chr6:109611834 NA -0.42 -7.29 -0.37 2.33e-12 Reticulocyte fraction of red cells; LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.9 13.68 0.6 3.95e-34 Alzheimer's disease; LUSC cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.73 0.35 7.22e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9457247 0.565 rs2239823 chr6:167512131 T/C cg06454157 chr6:167490870 NA -0.25 -5.68 -0.3 2.97e-8 Crohn's disease; LUSC trans rs3008870 0.755 rs2815380 chr1:67510857 A/G cg03415429 chr6:28048723 ZNF165 0.41 6.12 0.32 2.64e-9 Lymphocyte percentage of white cells; LUSC cis rs11785400 1.000 rs4736368 chr8:143748528 G/C cg24634471 chr8:143751801 JRK 0.59 8.88 0.44 4.24e-17 Schizophrenia; LUSC cis rs3862030 0.720 rs7341995 chr10:104223831 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -9.02 -0.44 1.52e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg14983838 chr19:29218262 NA 0.65 9.43 0.46 7.38e-19 Methadone dose in opioid dependence; LUSC cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs4555082 0.789 rs2816649 chr14:105708326 A/G cg27165867 chr14:105738592 BRF1 -0.56 -8.49 -0.42 6.7e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs2273669 0.667 rs7759014 chr6:109351125 A/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.05 -0.4 1.45e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs2236918 0.710 rs2526698 chr1:242029101 T/C cg17736920 chr1:242011382 EXO1 0.4 6.35 0.33 7.03e-10 Menopause (age at onset); LUSC cis rs9354308 0.834 rs12212376 chr6:66598879 T/C cg07460842 chr6:66804631 NA 0.46 5.66 0.3 3.2e-8 Metabolite levels; LUSC cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg14895029 chr7:2775587 GNA12 -0.35 -5.94 -0.31 7.05e-9 Height; LUSC cis rs6835098 0.962 rs4419455 chr4:174083622 C/T cg08422745 chr4:174089978 GALNT7 0.83 13.06 0.58 9.08e-32 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs2324229 0.730 rs1738632 chr6:83952189 T/G cg08257003 chr6:84140564 ME1 0.32 7.59 0.38 3.33e-13 Platelet-derived growth factor BB levels; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg21280719 chr6:42927975 GNMT -0.32 -7.98 -0.4 2.35e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9467711 0.606 rs71557334 chr6:26365913 G/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9905704 0.914 rs2643117 chr17:56829516 G/A cg12560992 chr17:57184187 TRIM37 0.55 7.78 0.39 9.28e-14 Testicular germ cell tumor; LUSC cis rs8141797 0.748 rs6004050 chr22:24461944 A/G cg00411358 chr22:24577142 SUSD2 0.61 6.32 0.33 8.56e-10 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs6496044 0.527 rs7163068 chr15:86072466 T/C cg13263323 chr15:86062960 AKAP13 -0.37 -6.16 -0.32 2.06e-9 Interstitial lung disease; LUSC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg06484146 chr7:12443880 VWDE -0.63 -7.41 -0.38 1.07e-12 Coronary artery disease; LUSC cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.38e-12 Motion sickness; LUSC cis rs1018836 0.923 rs6999898 chr8:91650549 G/A cg16814680 chr8:91681699 NA -0.82 -13.97 -0.61 3.06e-35 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 0.866 rs437635 chr20:25456888 A/G cg08601574 chr20:25228251 PYGB 0.41 6.25 0.32 1.22e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8005677 1.000 rs7155857 chr14:23400059 C/A cg00579484 chr14:23475993 C14orf93 0.39 5.74 0.3 2.12e-8 Cognitive ability (multi-trait analysis); LUSC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg24296786 chr1:45957014 TESK2 0.53 8.22 0.41 4.52e-15 High light scatter reticulocyte count; LUSC cis rs3126085 0.935 rs1496045 chr1:152184704 C/T cg03465714 chr1:152285911 FLG -0.42 -5.88 -0.31 9.75e-9 Atopic dermatitis; LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs921968 0.643 rs483172 chr2:219428299 A/G cg02176678 chr2:219576539 TTLL4 0.6 10.88 0.51 8.48e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg24642844 chr7:1081250 C7orf50 -0.48 -7.59 -0.38 3.3e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9653442 0.547 rs1062143 chr2:100659796 A/G cg22139774 chr2:100720529 AFF3 -0.47 -8.06 -0.4 1.34e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2486288 0.656 rs2413768 chr15:45561984 A/G cg09092052 chr15:45571596 NA 0.47 6.54 0.34 2.26e-10 Glomerular filtration rate; LUSC cis rs17255340 0.539 rs1170500 chr6:83991710 T/C cg08257003 chr6:84140564 ME1 0.32 7.89 0.4 4.39e-14 Platelet-derived growth factor BB levels; LUSC cis rs11098499 0.697 rs10020027 chr4:120381879 G/C cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.54e-25 Corneal astigmatism; LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs12681287 0.752 rs13255058 chr8:87287445 G/A cg27223183 chr8:87520930 FAM82B -0.45 -5.7 -0.3 2.69e-8 Caudate activity during reward; LUSC cis rs2806561 0.894 rs1738475 chr1:23536891 C/G cg19743168 chr1:23544995 NA 0.47 10.22 0.49 1.67e-21 Height; LUSC cis rs881375 0.678 rs10818488 chr9:123705087 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 5.96 0.31 6.32e-9 Rheumatoid arthritis; LUSC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg03709012 chr19:19516395 GATAD2A 0.74 11.36 0.53 1.69e-25 Tonsillectomy; LUSC cis rs2898681 0.561 rs58577680 chr4:53734294 C/T cg00791764 chr4:53727839 RASL11B 0.56 7.68 0.39 1.82e-13 Optic nerve measurement (cup area); LUSC cis rs2652834 0.718 rs2414811 chr15:63397725 C/T cg05507819 chr15:63340323 TPM1 0.56 7.13 0.36 6.22e-12 HDL cholesterol; LUSC cis rs3087591 0.960 rs1013947 chr17:29530362 C/T cg24425628 chr17:29625626 OMG;NF1 0.55 8.22 0.41 4.45e-15 Hip circumference; LUSC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg11859384 chr17:80120422 CCDC57 0.36 5.69 0.3 2.71e-8 Life satisfaction; LUSC cis rs6120849 0.754 rs752448 chr20:33592248 C/T cg24642439 chr20:33292090 TP53INP2 0.62 6.85 0.35 3.65e-11 Protein C levels; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg11905131 chr22:24372483 LOC391322 0.59 10.07 0.48 5.09e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26102683 chr11:82904715 ANKRD42 0.78 6.01 0.31 4.83e-9 Cognitive performance; LUSC cis rs6940638 0.688 rs6921388 chr6:27080205 A/G cg09904177 chr6:26538194 HMGN4 -0.47 -6.79 -0.35 5.03e-11 Intelligence (multi-trait analysis); LUSC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg22166914 chr1:53195759 ZYG11B 0.68 11.49 0.53 5.62e-26 Monocyte count; LUSC cis rs7208859 0.623 rs73271842 chr17:29137155 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg18404041 chr3:52824283 ITIH1 -0.57 -9.17 -0.45 4.92e-18 Schizophrenia; LUSC trans rs7647973 0.626 rs62260720 chr3:49853796 T/A cg21659725 chr3:3221576 CRBN 0.7 8.41 0.42 1.24e-15 Menarche (age at onset); LUSC trans rs7615952 0.599 rs6803160 chr3:125709554 G/T cg07211511 chr3:129823064 LOC729375 -0.8 -10.65 -0.5 5.31e-23 Blood pressure (smoking interaction); LUSC cis rs4478858 0.684 rs3753374 chr1:31740668 C/T cg00250761 chr1:31883323 NA -0.35 -8.37 -0.42 1.61e-15 Alcohol dependence; LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg20607798 chr8:58055168 NA 0.51 5.65 0.3 3.44e-8 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs7647973 1.000 rs13088309 chr3:49368317 A/G cg07636037 chr3:49044803 WDR6 0.64 8.47 0.42 7.76e-16 Menarche (age at onset); LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.57 -0.34 1.98e-10 Bipolar disorder and schizophrenia; LUSC cis rs6693567 0.545 rs5011187 chr1:150422761 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.1 0.36 7.33e-12 Migraine; LUSC cis rs6754311 0.517 rs60453613 chr2:136527120 G/C cg07169764 chr2:136633963 MCM6 0.87 12.05 0.55 4.98e-28 Mosquito bite size; LUSC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg03709012 chr19:19516395 GATAD2A 0.74 11.39 0.53 1.33e-25 Tonsillectomy; LUSC cis rs9902453 0.904 rs7218379 chr17:28402737 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.84 -0.51 1.16e-23 Coffee consumption (cups per day); LUSC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.1e-16 Aortic root size; LUSC cis rs9987353 0.566 rs34389718 chr8:9065525 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.45 -0.33 3.82e-10 Recombination measurement; LUSC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.95 -0.4 2.98e-14 Chronic sinus infection; LUSC cis rs1595825 0.891 rs73058867 chr2:198891568 A/G cg10547527 chr2:198650123 BOLL -0.52 -6.3 -0.33 9.56e-10 Ulcerative colitis; LUSC cis rs12594515 1.000 rs7173144 chr15:45991196 A/G cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC cis rs12200782 0.530 rs6929908 chr6:26555289 C/A cg11502198 chr6:26597334 ABT1 0.89 10.63 0.5 6.06e-23 Small cell lung carcinoma; LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg08948841 chr4:1244042 CTBP1;C4orf42 0.31 6.07 0.31 3.56e-9 Obesity-related traits; LUSC cis rs11785400 0.963 rs4579507 chr8:143733663 C/G cg10596483 chr8:143751796 JRK 0.61 9.4 0.46 9.11e-19 Schizophrenia; LUSC cis rs6005807 0.719 rs58542867 chr22:28988260 A/G cg12565055 chr22:29076175 TTC28 0.56 5.97 0.31 6.06e-9 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs9341808 0.690 rs2505932 chr6:80839252 G/T cg08355045 chr6:80787529 NA 0.47 8.21 0.41 4.88e-15 Sitting height ratio; LUSC cis rs1018836 0.545 rs4236827 chr8:91688943 A/T cg16814680 chr8:91681699 NA -1.05 -24.21 -0.8 1.77e-75 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs3008870 0.920 rs3008860 chr1:67391003 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.13 0.64 9.04e-40 Lymphocyte percentage of white cells; LUSC cis rs79057730 0.639 rs6463933 chr7:793954 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.73 7.47 0.38 6.89e-13 Initial pursuit acceleration; LUSC cis rs9311676 0.656 rs6773193 chr3:58385960 C/T cg13750441 chr3:58318267 PXK 0.35 6.72 0.35 7.86e-11 Systemic lupus erythematosus; LUSC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg09165964 chr15:75287851 SCAMP5 0.45 6.71 0.34 8.34e-11 Breast cancer; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4969178 0.965 rs938351 chr17:76399404 C/T cg05887092 chr17:76393375 PGS1 0.52 9.34 0.46 1.41e-18 HDL cholesterol levels; LUSC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg00129232 chr17:37814104 STARD3 -0.42 -6.16 -0.32 2.13e-9 Asthma; LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg06112835 chr11:68658793 MRPL21 0.51 7.54 0.38 4.53e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2289583 0.642 rs67624860 chr15:75391557 A/G cg14664628 chr15:75095509 CSK 0.43 6.07 0.32 3.43e-9 Systemic lupus erythematosus; LUSC cis rs1572072 0.545 rs1572073 chr13:24127240 C/T cg24350296 chr13:24144486 TNFRSF19 -0.31 -5.7 -0.3 2.57e-8 Nasopharyngeal carcinoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19557340 chr13:35516445 NBEA -0.47 -6.18 -0.32 1.84e-9 Bipolar disorder and schizophrenia; LUSC cis rs2933343 0.729 rs789230 chr3:128602558 G/A cg11901034 chr3:128598214 ACAD9 -0.4 -6.21 -0.32 1.57e-9 IgG glycosylation; LUSC trans rs62238980 0.614 rs2413064 chr22:32458536 G/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg06627628 chr2:24431161 ITSN2 0.61 7.39 0.37 1.21e-12 Lymphocyte counts; LUSC cis rs7572644 0.766 rs13016573 chr2:28094270 C/G cg27432699 chr2:27873401 GPN1 -0.51 -6.6 -0.34 1.62e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg12310025 chr6:25882481 NA -0.35 -5.78 -0.3 1.74e-8 Height; LUSC cis rs9283706 0.594 rs10515036 chr5:66343787 A/G cg11590213 chr5:66331682 MAST4 -0.48 -7.27 -0.37 2.5e-12 Coronary artery disease; LUSC cis rs2836633 1.000 rs2836631 chr21:40065906 G/T cg12884169 chr21:40033163 ERG -0.55 -10.82 -0.51 1.38e-23 Coronary artery disease; LUSC cis rs6484504 0.600 rs972714 chr11:31358875 T/G cg26647111 chr11:31128758 NA 0.4 5.65 0.3 3.36e-8 Red blood cell count; LUSC cis rs2304206 0.614 rs12104272 chr19:50148052 A/G cg09250473 chr19:50168907 IRF3;BCL2L12 -0.58 -8.84 -0.44 5.49e-17 Vitiligo; LUSC cis rs8062405 0.723 rs113208333 chr16:28606160 G/T cg16576597 chr16:28551801 NUPR1 0.3 6.01 0.31 4.79e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -7.43 -0.38 9.16e-13 Menarche (age at onset); LUSC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg04871131 chr7:94954202 PON1 0.38 6.05 0.31 3.87e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg03517284 chr6:25882590 NA -0.45 -7.73 -0.39 1.3e-13 Intelligence (multi-trait analysis); LUSC cis rs10779751 0.690 rs910661 chr1:11130116 C/A cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs9649213 0.586 rs11768599 chr7:97974555 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.71 -9.94 -0.48 1.49e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg22455342 chr2:225449267 CUL3 0.8 10.69 0.5 3.87e-23 IgE levels in asthmatics (D.p. specific); LUSC cis rs1385374 0.858 rs11059933 chr12:129303593 T/C cg09035930 chr12:129282057 SLC15A4 -0.61 -6.56 -0.34 2.11e-10 Systemic lupus erythematosus; LUSC cis rs62400317 0.859 rs12214749 chr6:45307906 A/G cg18551225 chr6:44695536 NA -0.45 -7.44 -0.38 8.38e-13 Total body bone mineral density; LUSC cis rs4595586 0.545 rs12812262 chr12:39392567 T/A cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24903225 chr12:108956097 SART3;ISCU 0.36 6.05 0.31 3.87e-9 Triglycerides; LUSC cis rs2795502 1.000 rs2795503 chr10:43347224 T/A cg20628663 chr10:43360327 NA -0.76 -11.3 -0.53 2.76e-25 Blood protein levels; LUSC cis rs1538970 0.816 rs4633317 chr1:45985157 T/C cg05343316 chr1:45956843 TESK2 0.72 9.75 0.47 6.34e-20 Platelet count; LUSC cis rs7560272 0.538 rs11126415 chr2:73936500 C/T cg20560298 chr2:73613845 ALMS1 0.4 6.11 0.32 2.8e-9 Schizophrenia; LUSC cis rs3768617 0.528 rs2027082 chr1:183084608 C/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg08736216 chr1:53307985 ZYG11A -0.29 -6.07 -0.32 3.5e-9 Monocyte count; LUSC cis rs2267137 0.574 rs5752910 chr22:29803493 A/G cg07256473 chr22:29710276 RASL10A 0.38 7.34 0.37 1.69e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg09509183 chr1:209979624 IRF6 -0.45 -7.06 -0.36 9.7e-12 Orofacial clefts; LUSC cis rs533581 0.866 rs871756 chr16:88969076 G/C cg08484992 chr16:88977278 CBFA2T3 0.35 6.13 0.32 2.41e-9 Social autistic-like traits; LUSC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg04539111 chr16:67997858 SLC12A4 -0.46 -6.26 -0.32 1.17e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg11244672 chr19:19639970 YJEFN3 0.58 7.26 0.37 2.73e-12 Bipolar disorder; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg18758796 chr5:131593413 PDLIM4 0.4 7.07 0.36 9.38e-12 Blood metabolite levels; LUSC cis rs8014204 0.544 rs2286913 chr14:75386576 G/A cg03030879 chr14:75389066 RPS6KL1 -0.4 -7.75 -0.39 1.14e-13 Caffeine consumption; LUSC cis rs7527798 0.592 rs6667238 chr1:207822856 G/A cg09232269 chr1:207846808 CR1L -0.3 -6.46 -0.33 3.78e-10 Erythrocyte sedimentation rate; LUSC cis rs1003719 0.788 rs4817843 chr21:38447040 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.29 0.53 3e-25 Eye color traits; LUSC cis rs2842992 0.747 rs4709379 chr6:160227530 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.74 8.87 0.44 4.4e-17 Age-related macular degeneration (geographic atrophy); LUSC trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg11887960 chr12:57824829 NA 0.58 7.05 0.36 1.05e-11 Lung disease severity in cystic fibrosis; LUSC cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.49 0.38 6.07e-13 Motion sickness; LUSC cis rs1322512 0.837 rs2758786 chr6:153013644 G/A cg27316956 chr6:152958899 SYNE1 0.36 6.19 0.32 1.81e-9 Tonometry; LUSC cis rs9311676 0.656 rs55783924 chr3:58403610 C/T cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11141652 chr22:24348549 GSTTP1 0.42 6.51 0.34 2.69e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.05e-10 Aortic root size; LUSC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg26314531 chr2:26401878 FAM59B -0.68 -9.1 -0.45 8.35e-18 Gut microbiome composition (summer); LUSC cis rs72781680 1.000 rs17763442 chr2:24255991 C/T cg20701182 chr2:24300061 SF3B14 0.82 8.15 0.41 7.36e-15 Lymphocyte counts; LUSC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg07701084 chr6:150067640 NUP43 0.54 8.09 0.4 1.09e-14 Lung cancer; LUSC cis rs7666738 0.546 rs10007424 chr4:98885450 C/T cg17366294 chr4:99064904 C4orf37 0.52 8.35 0.42 1.82e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.45 0.38 8.3e-13 Bipolar disorder; LUSC cis rs2274273 0.623 rs1187877 chr14:55495161 T/C cg04306507 chr14:55594613 LGALS3 -0.5 -11.01 -0.52 2.94e-24 Protein biomarker; LUSC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg13770153 chr20:60521292 NA -0.64 -8.62 -0.43 2.74e-16 Body mass index; LUSC trans rs62103177 0.733 rs62096747 chr18:77619568 A/G cg14227996 chr4:17616232 MED28 0.8 8.14 0.41 7.99e-15 Opioid sensitivity; LUSC trans rs2392780 0.512 rs594076 chr8:128334966 G/C cg10897648 chr18:56338258 MALT1 -0.41 -6.17 -0.32 1.92e-9 Breast cancer (early onset); LUSC cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg01579765 chr21:45077557 HSF2BP -0.47 -9.78 -0.47 5.04e-20 Mean corpuscular volume; LUSC trans rs7824557 0.767 rs11775635 chr8:11164865 G/A cg08975724 chr8:8085496 FLJ10661 0.45 6.69 0.34 9.62e-11 Retinal vascular caliber; LUSC cis rs6504340 0.739 rs4793943 chr17:46666937 C/G cg09704116 chr17:46666958 LOC404266 -0.37 -5.67 -0.3 3.13e-8 Primary tooth development (number of teeth); LUSC cis rs67981189 0.593 rs2877714 chr14:71568215 G/T cg15816911 chr14:71606274 NA 0.34 5.98 0.31 5.8e-9 Schizophrenia; LUSC cis rs3741798 1.000 rs73277486 chr12:12494761 T/C cg08615371 chr12:12503544 MANSC1 1.08 11.05 0.52 2.07e-24 Cerebrospinal fluid biomarker levels; LUSC cis rs174601 0.864 rs174545 chr11:61569306 C/G cg19610905 chr11:61596333 FADS2 -0.55 -8.27 -0.41 3.13e-15 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC cis rs1670533 1.000 rs604597 chr4:1094151 G/A cg16405210 chr4:1374714 KIAA1530 0.47 5.79 0.3 1.66e-8 Recombination rate (females); LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.27 0.32 1.11e-9 Menopause (age at onset); LUSC cis rs68170813 0.559 rs12538769 chr7:106984288 C/T cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.66 -0.3 3.23e-8 Coronary artery disease; LUSC trans rs7819412 0.502 rs4841499 chr8:10988138 A/C cg15556689 chr8:8085844 FLJ10661 -0.49 -6.51 -0.34 2.81e-10 Triglycerides; LUSC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg18681998 chr4:17616180 MED28 0.87 16.39 0.67 9.86e-45 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs708547 0.671 rs1718863 chr4:57887586 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.64 0.39 2.25e-13 Response to bleomycin (chromatid breaks); LUSC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12291225 0.679 rs34238445 chr11:14315915 C/T cg05501817 chr11:14380813 RRAS2 -0.56 -8.68 -0.43 1.79e-16 Sense of smell; LUSC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg14668632 chr7:2872130 GNA12 -0.45 -6.44 -0.33 4.05e-10 Height; LUSC cis rs4595586 0.505 rs12827136 chr12:39412790 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.48 0.38 6.51e-13 Morning vs. evening chronotype; LUSC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg23583168 chr7:148888333 NA -0.82 -13.3 -0.59 1.14e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs208515 0.525 rs10498841 chr6:66663706 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.01 13.69 0.6 3.59e-34 Exhaled nitric oxide levels; LUSC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg08219700 chr8:58056026 NA 0.5 6.4 0.33 5.22e-10 Developmental language disorder (linguistic errors); LUSC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg03264133 chr6:25882463 NA 0.61 10.21 0.49 1.71e-21 Blood metabolite levels; LUSC cis rs11098499 0.863 rs11933966 chr4:120476715 G/A cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg04414720 chr1:150670196 GOLPH3L 0.5 7.83 0.39 6.59e-14 Melanoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17599186 chr17:3572162 TMEM93;TAX1BP3 -0.42 -6.35 -0.33 7e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg26384229 chr12:38710491 ALG10B 0.92 15.52 0.65 2.71e-41 Bladder cancer; LUSC trans rs7824557 0.767 rs1897951 chr8:11169854 C/T cg06636001 chr8:8085503 FLJ10661 0.53 7.9 0.4 3.97e-14 Retinal vascular caliber; LUSC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg25204440 chr1:209979598 IRF6 0.5 5.72 0.3 2.4e-8 Cleft lip with or without cleft palate; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg04518342 chr5:131593106 PDLIM4 0.52 9.49 0.46 4.59e-19 Acylcarnitine levels; LUSC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.85 -0.35 3.59e-11 Developmental language disorder (linguistic errors); LUSC cis rs8030485 0.536 rs12595749 chr15:79432359 A/G cg17916960 chr15:79447300 NA 0.4 7.38 0.37 1.29e-12 Left ventricle wall thickness; LUSC cis rs11756438 0.572 rs1857312 chr6:119001526 A/C cg21191810 chr6:118973309 C6orf204 0.35 5.92 0.31 8.2e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg22875332 chr1:76189707 ACADM 0.84 13.26 0.59 1.52e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg02574844 chr11:5959923 NA -0.5 -6.81 -0.35 4.66e-11 DNA methylation (variation); LUSC cis rs4803468 1.000 rs1473248 chr19:41923314 C/T cg09537434 chr19:41945824 ATP5SL 0.9 15.57 0.65 1.82e-41 Height; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg12442385 chr7:1034912 NA -0.35 -6.1 -0.32 2.9e-9 Longevity;Endometriosis; LUSC trans rs7939886 0.844 rs2512784 chr11:55894186 G/A cg15704280 chr7:45808275 SEPT13 -0.72 -6.07 -0.32 3.47e-9 Myopia (pathological); LUSC cis rs9987353 0.519 rs2929465 chr8:9064002 C/G cg15556689 chr8:8085844 FLJ10661 -0.4 -5.82 -0.3 1.36e-8 Recombination measurement; LUSC cis rs16866061 0.517 rs7580488 chr2:225473263 C/T cg12698349 chr2:225449008 CUL3 0.47 7.12 0.36 6.56e-12 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs7927592 0.513 rs630225 chr11:68194611 A/C cg16797656 chr11:68205561 LRP5 0.47 8.37 0.42 1.56e-15 Total body bone mineral density; LUSC cis rs8017423 0.669 rs7153190 chr14:90703904 T/G cg04374321 chr14:90722782 PSMC1 0.73 11.32 0.53 2.29e-25 Mortality in heart failure; LUSC cis rs2219968 1.000 rs7003597 chr8:78976117 A/G cg00738934 chr8:78996279 NA 0.35 6.34 0.33 7.41e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg05347473 chr6:146136440 FBXO30 -0.61 -9.47 -0.46 5.47e-19 Lobe attachment (rater-scored or self-reported); LUSC trans rs12310956 0.515 rs1852221 chr12:33945489 G/T cg26384229 chr12:38710491 ALG10B 0.71 11.12 0.52 1.24e-24 Morning vs. evening chronotype; LUSC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg08392591 chr16:89556376 ANKRD11 0.46 7.19 0.37 4.39e-12 Multiple myeloma (IgH translocation); LUSC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg19318889 chr4:1322082 MAEA 0.57 9.71 0.47 8.22e-20 Longevity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14792983 chr20:18447909 C20orf12;POLR3F 0.47 6.78 0.35 5.39e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs17155006 0.746 rs401066 chr7:107747937 G/A cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs10216189 0.785 rs4623325 chr7:5526807 C/T cg11800390 chr7:5515995 FBXL18 -0.32 -6.71 -0.34 8.33e-11 Relative hand skill in reading disability; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09689279 chr15:49169965 SHC4;EID1 0.44 6.1 0.32 2.95e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.69 -8.59 -0.43 3.48e-16 Chronic sinus infection; LUSC cis rs6681460 0.549 rs7547794 chr1:67031878 A/G cg02459107 chr1:67143332 SGIP1 0.31 5.69 0.3 2.85e-8 Presence of antiphospholipid antibodies; LUSC cis rs11098499 1.000 rs3749591 chr4:120214030 T/G cg09307838 chr4:120376055 NA 0.74 10.61 0.5 7.28e-23 Corneal astigmatism; LUSC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.11 0.36 7.23e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg25554036 chr4:6271136 WFS1 -0.61 -12.65 -0.57 3.14e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg26446133 chr18:72167187 CNDP2 -0.81 -9.95 -0.48 1.35e-20 Refractive error; LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg08088566 chr11:430123 ANO9 0.72 7.77 0.39 9.65e-14 Body mass index; LUSC cis rs8028313 0.731 rs7172055 chr15:67938334 G/C cg27219399 chr15:67835830 MAP2K5 0.36 5.86 0.31 1.14e-8 Obesity; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.65 0.65 8.56e-42 Platelet count; LUSC cis rs2236918 0.687 rs851778 chr1:242037110 A/G cg17736920 chr1:242011382 EXO1 0.42 6.63 0.34 1.32e-10 Menopause (age at onset); LUSC cis rs7647973 0.925 rs4955423 chr3:49220448 G/A cg07636037 chr3:49044803 WDR6 0.69 8.83 0.44 5.99e-17 Menarche (age at onset); LUSC cis rs7089973 0.604 rs2420069 chr10:116605103 A/G cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11098499 0.908 rs7695996 chr4:120322033 C/T cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs5769707 0.749 rs8137251 chr22:50036669 G/A cg05373962 chr22:49881684 NA -0.4 -8.97 -0.44 2.25e-17 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12893668 0.703 rs4906337 chr14:104040414 C/A cg04998671 chr14:104000505 TRMT61A -0.48 -6.71 -0.34 8.58e-11 Reticulocyte count; LUSC cis rs4285028 0.948 rs34696871 chr3:121671880 T/G cg11130432 chr3:121712080 ILDR1 -0.61 -9.18 -0.45 4.74e-18 Multiple sclerosis; LUSC cis rs2898290 0.593 rs1600252 chr8:11345644 A/G cg21775007 chr8:11205619 TDH -0.5 -7.54 -0.38 4.51e-13 Systolic blood pressure; LUSC cis rs7927592 0.913 rs11228293 chr11:68384646 T/C cg01657329 chr11:68192670 LRP5 -0.4 -5.76 -0.3 1.92e-8 Total body bone mineral density; LUSC cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg23711669 chr6:146136114 FBXO30 0.72 12.82 0.57 7.47e-31 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08802696 chr7:44240534 YKT6 0.44 6.49 0.33 3.05e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.93 -0.55 1.41e-27 Extrinsic epigenetic age acceleration; LUSC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg08355456 chr11:67383691 NA 0.46 8.67 0.43 1.89e-16 Mean corpuscular volume; LUSC cis rs240764 0.817 rs11155610 chr6:101170233 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.12 -0.32 2.61e-9 Neuroticism; LUSC cis rs16976116 0.851 rs28784096 chr15:55503312 C/T cg11288833 chr15:55489084 RSL24D1 0.51 6.16 0.32 2.05e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9399401 0.601 rs262113 chr6:142824950 T/G cg03128060 chr6:142623767 GPR126 0.55 8.92 0.44 3.16e-17 Chronic obstructive pulmonary disease; LUSC cis rs868036 0.718 rs2241420 chr15:68082816 G/A cg08079166 chr15:68083412 MAP2K5 0.41 7.46 0.38 7.5e-13 Restless legs syndrome; LUSC cis rs7584330 0.695 rs77922291 chr2:238366317 T/G cg16989719 chr2:238392110 NA -0.38 -6.57 -0.34 1.92e-10 Prostate cancer; LUSC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg09650180 chr20:62225654 GMEB2 -0.67 -9.77 -0.47 5.56e-20 Glioblastoma; LUSC cis rs34779708 0.897 rs12764820 chr10:35386321 G/A cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg01238044 chr22:24384105 GSTT1 -0.62 -9.65 -0.47 1.38e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 1.000 rs2387881 chr20:25378172 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.32 -0.74 2.4e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3815700 1.000 rs7248845 chr19:33096718 T/C cg02997394 chr19:33096574 ANKRD27 0.82 9.32 0.45 1.68e-18 Eosinophilic esophagitis; LUSC cis rs6076065 0.723 rs2275787 chr20:23338486 A/G cg11657817 chr20:23433608 CST11 0.43 8.09 0.4 1.15e-14 Facial morphology (factor 15, philtrum width); LUSC trans rs853679 0.546 rs35819751 chr6:27810569 A/G cg06606381 chr12:133084897 FBRSL1 -1.02 -9.1 -0.45 8.46e-18 Depression; LUSC trans rs7829975 0.774 rs1039915 chr8:8679614 T/C cg27411982 chr8:10470053 RP1L1 0.41 6.27 0.32 1.14e-9 Mood instability; LUSC cis rs2398893 0.960 rs7849645 chr9:96744232 A/T cg14459158 chr9:96720562 NA 0.32 5.89 0.31 9.33e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.78 0.43 8.88e-17 Motion sickness; LUSC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11890956 chr21:40555474 PSMG1 1.03 21.08 0.76 2.6e-63 Cognitive function; LUSC cis rs12908161 0.959 rs62019472 chr15:85331493 A/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.5 0.34 2.86e-10 Schizophrenia; LUSC cis rs7267979 1.000 rs6050629 chr20:25430680 G/A cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg04944784 chr2:26401820 FAM59B 0.78 11.21 0.52 5.54e-25 Gut microbiome composition (summer); LUSC cis rs243505 0.660 rs7785022 chr7:148533384 C/T cg09806900 chr7:148480153 CUL1 0.48 6.49 0.33 3.19e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg14004847 chr7:1930337 MAD1L1 0.55 8.28 0.41 3.07e-15 Bipolar disorder and schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14584159 chr10:134351371 INPP5A -0.53 -6.05 -0.31 3.81e-9 Bipolar disorder and schizophrenia; LUSC cis rs7250872 0.647 rs2304613 chr19:1817943 G/C cg10370574 chr19:1840461 REXO1 -0.55 -7.92 -0.4 3.54e-14 Bipolar disorder; LUSC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC cis rs12681287 0.752 rs10103229 chr8:87248954 C/T cg27223183 chr8:87520930 FAM82B 0.47 6.03 0.31 4.36e-9 Caudate activity during reward; LUSC cis rs3540 0.597 rs7498113 chr15:91051192 C/G cg22089800 chr15:90895588 ZNF774 -0.64 -9.63 -0.47 1.52e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs733592 0.507 rs56129148 chr12:48485530 T/C cg24011408 chr12:48396354 COL2A1 -0.53 -8.72 -0.43 1.38e-16 Plateletcrit; LUSC cis rs9494145 0.680 rs4895441 chr6:135426573 C/T cg22676075 chr6:135203613 NA -0.61 -9.0 -0.44 1.73e-17 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC trans rs3749237 1.000 rs11130216 chr3:49736172 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.52 7.2 0.37 3.94e-12 Resting heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00821098 chr10:101419190 ENTPD7 0.42 6.59 0.34 1.7e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7567389 0.740 rs1604817 chr2:127999921 C/T cg09760422 chr2:128146352 NA -0.31 -6.53 -0.34 2.39e-10 Self-rated health; LUSC cis rs7575217 0.552 rs13032971 chr2:101689726 T/G cg23907051 chr2:101730305 TBC1D8 0.26 6.49 0.33 3.17e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs7267979 1.000 rs2500446 chr20:25339664 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.18 -0.71 7.93e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg11247378 chr22:39784982 NA -0.66 -13.0 -0.58 1.52e-31 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -11.76 -0.54 5.89e-27 Extrinsic epigenetic age acceleration; LUSC trans rs11088226 0.681 rs2833897 chr21:33931792 T/C cg09050820 chr6:167586206 TCP10L2 0.74 9.55 0.46 2.82e-19 Gastritis; LUSC cis rs2692947 0.644 rs1168975 chr2:96814075 G/A cg23100626 chr2:96804247 ASTL 0.3 7.17 0.37 4.93e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4141404 0.757 rs5749272 chr22:31830351 C/T cg22777020 chr22:31556080 RNF185 -0.41 -5.8 -0.3 1.57e-8 Paclitaxel-induced neuropathy; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03066081 chr17:77784036 NA 0.42 6.05 0.31 3.95e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg06445916 chr8:42268472 NA -0.4 -6.04 -0.31 4.11e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11608355 0.545 rs9943764 chr12:109905720 G/A cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs7561273 0.609 rs6720226 chr2:24295853 A/G cg06627628 chr2:24431161 ITSN2 -0.51 -6.83 -0.35 4.03e-11 Quantitative traits; LUSC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg27432699 chr2:27873401 GPN1 -0.56 -8.21 -0.41 5.03e-15 Total body bone mineral density; LUSC cis rs644799 0.544 rs1727165 chr11:95521648 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.32 0.45 1.58e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg07701084 chr6:150067640 NUP43 0.58 9.06 0.44 1.15e-17 Lung cancer; LUSC cis rs1559088 0.803 rs10405770 chr19:33616549 C/T cg17764715 chr19:33622953 WDR88 0.54 7.4 0.38 1.12e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.26 34.13 0.88 6.59e-111 Chronic sinus infection; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03911494 chr16:71660463 MARVELD3 0.73 5.96 0.31 6.46e-9 Cognitive performance; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14460708 chr3:172428874 NCEH1 0.52 7.68 0.39 1.78e-13 Triglycerides; LUSC trans rs3198697 1.000 rs3198697 chr16:15129940 C/T cg04146151 chr16:2155961 PKD1 -0.45 -7.56 -0.38 3.8e-13 Triglycerides; LUSC cis rs9457247 0.602 rs6456152 chr6:167472062 A/G cg06454157 chr6:167490870 NA -0.29 -6.78 -0.35 5.52e-11 Crohn's disease; LUSC cis rs10779751 0.881 rs2744815 chr1:11360957 C/T cg08854313 chr1:11322531 MTOR 0.73 12.03 0.55 6.36e-28 Body mass index; LUSC trans rs6601327 0.607 rs13276086 chr8:9578982 T/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.58 -0.34 1.83e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7264396 0.561 rs6058387 chr20:34568092 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.73 -0.35 7.21e-11 Total cholesterol levels; LUSC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg10130564 chr11:117069849 TAGLN 0.37 6.32 0.33 8.21e-10 Blood protein levels; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.68 10.84 0.51 1.21e-23 Prudent dietary pattern; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg12897942 chr3:170626357 EIF5A2 0.39 6.28 0.32 1.03e-9 Schizophrenia; LUSC cis rs7621025 0.500 rs12629000 chr3:136643571 T/A cg15507776 chr3:136538369 TMEM22 0.61 8.42 0.42 1.13e-15 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.723 rs61182696 chr3:42032511 C/T cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs739401 0.595 rs402806 chr11:3066432 A/G cg05729581 chr11:3078854 CARS -0.58 -8.91 -0.44 3.37e-17 Longevity; LUSC cis rs4268898 0.552 rs6754391 chr2:24369019 C/T cg06627628 chr2:24431161 ITSN2 -0.52 -7.43 -0.38 9.23e-13 Asthma; LUSC cis rs950169 0.580 rs11636189 chr15:85193554 G/A cg11189052 chr15:85197271 WDR73 0.48 6.08 0.32 3.22e-9 Schizophrenia; LUSC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg27398817 chr8:82754497 SNX16 -0.65 -8.24 -0.41 4e-15 Diastolic blood pressure; LUSC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.46 -0.38 7.74e-13 Personality dimensions; LUSC cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg05283184 chr6:79620031 NA -0.57 -12.03 -0.55 6.01e-28 Intelligence (multi-trait analysis); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg23450324 chr2:170551086 KLHL23;C2orf77;PHOSPHO2 0.4 5.99 0.31 5.53e-9 Mosquito bite size; LUSC cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg05738196 chr6:26577821 NA -0.52 -8.21 -0.41 5.04e-15 Schizophrenia; LUSC cis rs1003719 0.843 rs1003721 chr21:38492657 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.61 9.69 0.47 1.03e-19 Eye color traits; LUSC trans rs6601327 0.571 rs7838571 chr8:9647796 A/G cg08975724 chr8:8085496 FLJ10661 0.45 6.54 0.34 2.36e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs6500596 0.506 rs1530088 chr16:4439131 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.48 5.96 0.31 6.56e-9 Schizophrenia; LUSC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg02423579 chr7:2872169 GNA12 -0.44 -5.98 -0.31 5.78e-9 Height; LUSC cis rs7149337 0.837 rs10132658 chr14:51677599 C/T cg23942311 chr14:51606299 NA 0.47 10.31 0.49 7.99e-22 Cancer; LUSC trans rs1997103 1.000 rs4947499 chr7:55407196 T/C cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7923609 0.846 rs7073753 chr10:65062820 C/T cg01631684 chr10:65280961 REEP3 -0.38 -5.65 -0.3 3.44e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs8032315 0.965 rs8027450 chr15:91418394 C/T cg04510874 chr15:91427884 FES 0.3 5.89 0.31 9.25e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg22535103 chr8:58192502 C8orf71 -0.67 -7.55 -0.38 4.15e-13 Developmental language disorder (linguistic errors); LUSC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg20607287 chr7:12443886 VWDE -0.65 -6.44 -0.33 4.17e-10 Coronary artery disease; LUSC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg02569458 chr12:86230093 RASSF9 0.55 9.37 0.46 1.12e-18 Major depressive disorder; LUSC cis rs2274273 0.624 rs11158034 chr14:55753560 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.85 0.47 2.9e-20 Protein biomarker; LUSC cis rs73200209 0.744 rs17498872 chr12:116669888 A/T cg01776926 chr12:116560359 MED13L -0.49 -5.98 -0.31 5.8e-9 Total body bone mineral density; LUSC cis rs7829975 0.606 rs7819827 chr8:8797055 G/C cg06636001 chr8:8085503 FLJ10661 -0.54 -8.59 -0.43 3.43e-16 Mood instability; LUSC cis rs4417855 0.794 rs3868898 chr3:187425632 A/T cg19198148 chr3:187451818 BCL6 0.57 10.3 0.49 8.38e-22 Granulocyte percentage of myeloid white cells; LUSC trans rs1005277 0.579 rs2474580 chr10:38398713 G/A cg17830980 chr10:43048298 ZNF37B -0.59 -9.53 -0.46 3.44e-19 Extrinsic epigenetic age acceleration; LUSC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg02569458 chr12:86230093 RASSF9 0.47 7.47 0.38 6.9e-13 Major depressive disorder; LUSC cis rs34330 0.562 rs12229100 chr12:12865836 A/G cg09462578 chr12:12878428 APOLD1 0.64 7.54 0.38 4.62e-13 Systemic lupus erythematosus; LUSC cis rs9473147 0.516 rs9296564 chr6:47494759 A/G cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.38 -0.42 1.47e-15 Schizophrenia; LUSC cis rs1018836 0.892 rs4735210 chr8:91549399 G/T cg16814680 chr8:91681699 NA -0.69 -11.28 -0.53 3.19e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg08859206 chr1:53392774 SCP2 -0.42 -6.74 -0.35 7.06e-11 Monocyte count; LUSC cis rs62400317 0.859 rs72858517 chr6:45223467 A/C cg18551225 chr6:44695536 NA -0.44 -7.34 -0.37 1.63e-12 Total body bone mineral density; LUSC cis rs968567 0.705 rs174575 chr11:61602003 C/G cg19610905 chr11:61596333 FADS2 -0.42 -5.91 -0.31 8.55e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg05868516 chr6:26286170 HIST1H4H 0.37 6.09 0.32 3.03e-9 Educational attainment; LUSC cis rs72772090 0.710 rs17479052 chr5:96065636 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -7.43 -0.38 9.39e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.62e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs3942852 0.712 rs2174129 chr11:48108557 A/C cg03929089 chr4:120376271 NA -0.54 -6.73 -0.35 7.51e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg05283184 chr6:79620031 NA -0.55 -11.32 -0.53 2.38e-25 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg19622623 chr12:86230825 RASSF9 0.4 5.92 0.31 7.89e-9 Major depressive disorder; LUSC cis rs1018836 1.000 rs1018836 chr8:91570362 A/G cg16814680 chr8:91681699 NA -0.69 -10.98 -0.52 3.69e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg00071950 chr4:10020882 SLC2A9 0.61 10.08 0.48 5.02e-21 Bone mineral density; LUSC cis rs2625529 0.617 rs2929509 chr15:72239272 T/C cg16672083 chr15:72433130 SENP8 0.48 8.08 0.4 1.17e-14 Red blood cell count; LUSC cis rs6982240 0.514 rs10093988 chr8:142260995 T/C cg00131261 chr8:142287264 NA -0.36 -6.0 -0.31 5.17e-9 Tonsillectomy; LUSC cis rs7267979 0.932 rs431579 chr20:25470056 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.61e-62 Liver enzyme levels (alkaline phosphatase); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg06703304 chr16:68057150 DUS2L;DDX28 0.39 5.95 0.31 6.83e-9 N-glycan levels; LUSC trans rs747782 0.639 rs17198985 chr11:48183565 T/C cg03929089 chr4:120376271 NA 0.7 6.48 0.33 3.37e-10 Intraocular pressure; LUSC cis rs853679 0.607 rs67101035 chr6:27798887 C/G cg26958806 chr6:27640298 NA 0.81 6.28 0.32 1.05e-9 Depression; LUSC cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7312933 0.584 rs7974654 chr12:42630466 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 7.05 0.36 1.01e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs12478296 0.591 rs4973646 chr2:243001373 C/T cg01596870 chr19:55963115 NA 0.56 7.43 0.38 9.05e-13 Obesity-related traits; LUSC cis rs9534288 0.912 rs4942468 chr13:46618290 C/A cg15192986 chr13:46630673 CPB2 -0.73 -11.27 -0.52 3.51e-25 Blood protein levels; LUSC cis rs41271473 0.500 rs4606285 chr1:228887544 G/T cg16512390 chr1:228756714 NA 0.5 7.31 0.37 1.97e-12 Chronic lymphocytic leukemia; LUSC cis rs950776 0.752 rs2869546 chr15:78907345 C/T cg06917634 chr15:78832804 PSMA4 -0.7 -11.63 -0.54 1.76e-26 Sudden cardiac arrest; LUSC cis rs67311347 0.713 rs4974018 chr3:40307419 G/A cg02782426 chr3:40428986 ENTPD3 0.33 6.67 0.34 1.09e-10 Renal cell carcinoma; LUSC cis rs7903847 0.642 rs10786339 chr10:99153076 A/G cg08345082 chr10:99160200 RRP12 -0.35 -7.2 -0.37 3.91e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg25174290 chr11:3078921 CARS 0.6 9.58 0.46 2.28e-19 Longevity; LUSC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg05425664 chr17:57184151 TRIM37 -0.57 -8.45 -0.42 9.38e-16 Intelligence (multi-trait analysis); LUSC cis rs500891 0.620 rs3812144 chr6:84141253 T/G cg08257003 chr6:84140564 ME1 0.37 9.19 0.45 4.23e-18 Platelet-derived growth factor BB levels; LUSC trans rs2392780 0.536 rs631845 chr8:128338760 G/A cg10195415 chr17:73887371 TRIM65 0.41 6.64 0.34 1.3100000000000001e-10 Breast cancer (early onset); LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg07507251 chr3:52567010 NT5DC2 0.36 7.01 0.36 1.29e-11 Bipolar disorder; LUSC cis rs4253772 0.938 rs41371446 chr22:46637272 T/C cg09491104 chr22:46646882 C22orf40 -0.62 -6.62 -0.34 1.47e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs7615316 0.902 rs6440091 chr3:142313515 C/T cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.61e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4561483 0.645 rs2192645 chr16:11928019 C/T cg08843971 chr16:11963173 GSPT1 -0.38 -5.79 -0.3 1.63e-8 Testicular germ cell tumor; LUSC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg16606324 chr3:10149918 C3orf24 0.44 6.83 0.35 4.05e-11 Alzheimer's disease; LUSC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.86 -0.31 1.13e-8 Alzheimer's disease (late onset); LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg01802117 chr1:53393560 SCP2 -0.4 -6.75 -0.35 6.51e-11 Monocyte count; LUSC cis rs8014204 0.935 rs1799900 chr14:75367740 G/A cg06637938 chr14:75390232 RPS6KL1 -0.67 -11.16 -0.52 8.79e-25 Caffeine consumption; LUSC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg04719120 chr6:96025338 MANEA 0.46 5.81 0.3 1.45e-8 Behavioural disinhibition (generation interaction); LUSC cis rs34311866 0.808 rs3755958 chr4:963042 C/A cg07828340 chr4:882639 GAK 0.97 9.67 0.47 1.14e-19 Parkinson's disease; LUSC cis rs1322512 0.677 rs1727040 chr6:152937509 G/A cg27316956 chr6:152958899 SYNE1 -0.36 -5.94 -0.31 7.06e-9 Tonometry; LUSC cis rs2243480 1.000 rs709607 chr7:65449541 C/G cg18252515 chr7:66147081 NA 1.0 9.75 0.47 6.2e-20 Diabetic kidney disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03150409 chr4:1892317 WHSC1 -0.44 -7.72 -0.39 1.38e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9303401 0.580 rs12603808 chr17:56578508 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.83 12.59 0.57 5.23e-30 Cognitive test performance; LUSC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg02503808 chr4:7069936 GRPEL1 -1.03 -11.28 -0.53 3.09e-25 Monocyte percentage of white cells; LUSC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg04287289 chr16:89883240 FANCA 0.78 6.24 0.32 1.3e-9 Skin colour saturation; LUSC trans rs2797160 0.967 rs2797159 chr6:126009557 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs929354 0.772 rs1182448 chr7:157021415 G/A cg17757837 chr7:157058334 UBE3C -0.82 -13.31 -0.59 1.01e-32 Body mass index; LUSC cis rs1178968 0.901 rs7779909 chr7:72751966 G/T cg25889504 chr7:72793014 NA 0.57 7.85 0.39 5.62e-14 Triglyceride levels; LUSC cis rs240764 0.817 rs239207 chr6:101137765 A/C cg09795085 chr6:101329169 ASCC3 0.42 6.17 0.32 2.01e-9 Neuroticism; LUSC cis rs28493229 0.881 rs10404911 chr19:41174903 A/T cg21869046 chr19:41225005 ITPKC 0.54 7.23 0.37 3.38e-12 Kawasaki disease; LUSC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg08219700 chr8:58056026 NA 0.43 5.68 0.3 2.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs6940638 0.662 rs7759694 chr6:27240956 C/T cg12826209 chr6:26865740 GUSBL1 0.45 6.39 0.33 5.61e-10 Intelligence (multi-trait analysis); LUSC cis rs68170813 0.559 rs6963917 chr7:106953427 T/G cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC cis rs1865760 0.622 rs10946807 chr6:26079638 T/C cg16482183 chr6:26056742 HIST1H1C 0.65 9.37 0.46 1.15e-18 Height; LUSC cis rs7617773 0.963 rs12495221 chr3:48179178 C/T cg11946769 chr3:48343235 NME6 -0.63 -9.41 -0.46 8.57e-19 Coronary artery disease; LUSC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.08 -0.4 1.19e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs8141529 0.719 rs2097461 chr22:29191879 T/C cg02153584 chr22:29168773 CCDC117 0.65 10.52 0.5 1.52e-22 Lymphocyte counts; LUSC cis rs10504229 0.679 rs72649131 chr8:58054288 G/T cg21724239 chr8:58056113 NA 0.56 6.66 0.34 1.13e-10 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09608387 chr6:150464020 PPP1R14C -0.51 -6.18 -0.32 1.84e-9 Bipolar disorder and schizophrenia; LUSC cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14442939 chr10:27389572 ANKRD26 0.83 9.47 0.46 5.11e-19 Breast cancer; LUSC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg16262614 chr3:133464971 TF 0.43 7.56 0.38 3.85e-13 Iron status biomarkers (transferrin levels); LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg14004847 chr7:1930337 MAD1L1 0.61 9.66 0.47 1.22e-19 Bipolar disorder and schizophrenia; LUSC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg12311346 chr5:56204834 C5orf35 -0.94 -13.88 -0.6 6.62e-35 Initial pursuit acceleration; LUSC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg12311346 chr5:56204834 C5orf35 -0.92 -13.66 -0.6 4.74e-34 Initial pursuit acceleration; LUSC cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg18252515 chr7:66147081 NA -1.19 -12.75 -0.57 1.35e-30 Diabetic kidney disease; LUSC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg23985595 chr17:80112537 CCDC57 0.32 6.16 0.32 2.15e-9 Life satisfaction; LUSC cis rs2637266 0.783 rs846597 chr10:78529114 A/G cg18941641 chr10:78392320 NA 0.38 6.79 0.35 5.11e-11 Pulmonary function; LUSC cis rs3867498 0.550 rs12901127 chr15:25074586 A/C cg02919448 chr15:24122782 NA -0.33 -6.14 -0.32 2.29e-9 Pulmonary function; LUSC trans rs890448 0.796 rs2471673 chr4:102353587 C/T cg05120309 chr14:100485494 NA -0.36 -6.02 -0.31 4.67e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg03453431 chr7:157225567 NA -0.58 -10.37 -0.49 4.84e-22 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs3820068 0.677 rs72643691 chr1:15856251 T/C cg17385448 chr1:15911702 AGMAT 0.36 5.86 0.31 1.12e-8 Systolic blood pressure; LUSC cis rs9341835 0.518 rs6942342 chr6:64176447 T/C cg03326410 chr6:64151739 NA -0.37 -6.01 -0.31 4.8e-9 Schizophrenia; LUSC cis rs10992471 0.756 rs2516568 chr9:95187380 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -8.2 -0.41 5.24e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4566357 0.615 rs10178260 chr2:227914458 G/T cg11843606 chr2:227700838 RHBDD1 -0.53 -8.2 -0.41 5.4e-15 Coronary artery disease; LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.21 0.56 1.31e-28 Colorectal cancer; LUSC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg03676636 chr4:99064102 C4orf37 0.34 7.46 0.38 7.44e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4629710 0.534 rs6916881 chr6:131565153 C/T cg12606694 chr6:131520996 AKAP7 0.6 9.27 0.45 2.39e-18 Multiple myeloma (IgH translocation); LUSC cis rs929354 0.629 rs6950739 chr7:156982450 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.19e-19 Body mass index; LUSC trans rs57046232 0.552 rs6038443 chr20:6328844 A/G cg17788362 chr6:86352627 SYNCRIP 0.45 6.23 0.32 1.38e-9 Colorectal cancer; LUSC trans rs853679 0.882 rs9461432 chr6:28086883 T/C cg06606381 chr12:133084897 FBRSL1 -0.69 -7.52 -0.38 5.05e-13 Depression; LUSC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.6 9.15 0.45 5.74e-18 Height; LUSC trans rs747782 0.640 rs11039603 chr11:48256786 G/A cg15704280 chr7:45808275 SEPT13 0.77 6.64 0.34 1.27e-10 Intraocular pressure; LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg08088566 chr11:430123 ANO9 0.61 7.07 0.36 8.89e-12 Body mass index; LUSC cis rs8078723 1.000 rs6503530 chr17:38161823 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.94 -0.36 1.99e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs968451 0.865 rs5757611 chr22:39708357 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.66 8.89 0.44 3.81e-17 Primary biliary cholangitis; LUSC cis rs2708377 0.929 rs2600337 chr12:11293130 G/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.8 -7.8 -0.39 7.98e-14 Bitter taste perception; LUSC cis rs2970818 0.764 rs61909578 chr12:4570303 G/C cg11146114 chr12:4671731 NA -0.64 -6.14 -0.32 2.31e-9 Phosphorus levels; LUSC cis rs926392 0.965 rs6129167 chr20:37689228 C/T cg27552599 chr20:37590471 DHX35 -0.34 -5.94 -0.31 7.04e-9 Dialysis-related mortality; LUSC trans rs3960554 0.932 rs4728597 chr7:75821062 C/T cg19862616 chr7:65841803 NCRNA00174 0.89 9.72 0.47 8.08e-20 Eotaxin levels; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.4 6.05 0.31 3.93e-9 Calcium levels; LUSC cis rs1568889 1.000 rs12796293 chr11:28177723 C/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.62 -9.25 -0.45 2.76e-18 Bipolar disorder; LUSC cis rs7674212 0.541 rs2251322 chr4:104079424 C/T cg16532752 chr4:104119610 CENPE -0.5 -7.4 -0.38 1.11e-12 Type 2 diabetes; LUSC cis rs9650657 0.537 rs7016385 chr8:10779472 A/G cg21775007 chr8:11205619 TDH 0.44 5.95 0.31 6.85e-9 Neuroticism; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg04025307 chr7:1156635 C7orf50 0.42 6.37 0.33 6.36e-10 Longevity;Endometriosis; LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.05 0.31 3.95e-9 Menopause (age at onset); LUSC cis rs12155623 0.834 rs6472110 chr8:49784810 T/C cg22283653 chr8:49824208 NA -0.39 -7.51 -0.38 5.61e-13 Sudden cardiac arrest; LUSC cis rs6982240 0.514 rs28588820 chr8:142285342 C/T cg27411547 chr8:142287226 NA -0.47 -7.61 -0.38 2.85e-13 Tonsillectomy; LUSC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg01475377 chr6:109611718 NA 0.41 7.16 0.36 5.08e-12 Reticulocyte fraction of red cells; LUSC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg07636037 chr3:49044803 WDR6 0.44 6.41 0.33 4.89e-10 Resting heart rate; LUSC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg09365446 chr1:150670422 GOLPH3L 0.52 7.9 0.4 4.17e-14 Tonsillectomy; LUSC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg11266682 chr4:10021025 SLC2A9 0.58 10.63 0.5 6.51e-23 Bone mineral density; LUSC cis rs77106637 1.000 rs11605166 chr11:72669777 T/C cg03878208 chr11:72483293 STARD10 0.59 7.58 0.38 3.54e-13 Type 2 diabetes; LUSC cis rs1005224 0.963 rs2303345 chr14:76156609 A/G cg04684003 chr14:76127793 TTLL5;C14orf1 0.61 8.4 0.42 1.32e-15 Large artery stroke; LUSC cis rs7937682 0.883 rs1611989 chr11:111456299 A/G cg19812747 chr11:111475976 SIK2 -0.55 -8.08 -0.4 1.16e-14 Primary sclerosing cholangitis; LUSC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg05785598 chr3:49045655 WDR6 0.37 6.52 0.34 2.54e-10 Parkinson's disease; LUSC cis rs4820539 1.000 rs5751589 chr22:23475762 A/G cg14186256 chr22:23484241 RTDR1 -0.95 -17.57 -0.69 2.17e-49 Bone mineral density; LUSC cis rs10203711 1.000 rs10207724 chr2:239566705 G/C cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -6.52 -0.34 2.58e-10 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.771 rs2842613 chr6:86305702 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 10.8 0.51 1.58e-23 Response to antipsychotic treatment; LUSC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.35 -5.71 -0.3 2.45e-8 Total body bone mineral density; LUSC cis rs55910451 0.525 rs17143628 chr10:5832205 C/T cg11519256 chr10:5708881 ASB13 -0.46 -6.04 -0.31 4.15e-9 Breast cancer; LUSC cis rs6840360 0.571 rs62327278 chr4:152558790 G/C cg22705602 chr4:152727874 NA -0.3 -5.94 -0.31 7.11e-9 Intelligence (multi-trait analysis); LUSC cis rs4964805 0.954 rs10861105 chr12:104189999 C/T cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC cis rs4595586 1.000 rs4595586 chr12:39225991 A/T cg26384229 chr12:38710491 ALG10B -0.4 -5.66 -0.3 3.34e-8 Morning vs. evening chronotype; LUSC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.88 -0.35 3.04e-11 Mean platelet volume; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18881962 chr6:1604697 NA 0.72 6.24 0.32 1.34e-9 Cognitive performance; LUSC cis rs12579753 0.917 rs4842410 chr12:82219225 A/T cg07988820 chr12:82153109 PPFIA2 -0.44 -6.26 -0.32 1.15e-9 Resting heart rate; LUSC cis rs7804356 1.000 rs58760954 chr7:26850776 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs4595586 0.545 rs7294600 chr12:39373416 A/G cg26384229 chr12:38710491 ALG10B 0.49 6.99 0.36 1.51e-11 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg26314531 chr2:26401878 FAM59B 0.75 10.1 0.48 4.27e-21 Gut microbiome composition (summer); LUSC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg23262073 chr20:60523788 NA -0.42 -6.0 -0.31 5.03e-9 Body mass index; LUSC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -14.08 -0.61 1.14e-35 Extrinsic epigenetic age acceleration; LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg01802117 chr1:53393560 SCP2 0.37 6.0 0.31 5.15e-9 Monocyte count; LUSC cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.61e-8 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9296092 0.500 rs4376348 chr6:33521097 A/G cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.77e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs28735056 0.592 rs2277725 chr18:77694168 A/C cg20368463 chr18:77673604 PQLC1 -0.71 -10.84 -0.51 1.13e-23 Schizophrenia; LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg25767906 chr1:53392781 SCP2 0.48 8.71 0.43 1.47e-16 Monocyte count; LUSC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg22535103 chr8:58192502 C8orf71 -0.72 -7.18 -0.37 4.53e-12 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs34418276 chr12:34535976 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.35 0.49 5.93e-22 Morning vs. evening chronotype; LUSC cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.5 8.16 0.41 6.86e-15 IgG glycosylation; LUSC cis rs2014572 0.967 rs8111977 chr19:57759158 T/A cg24459738 chr19:57751996 ZNF805 -0.52 -7.61 -0.38 2.91e-13 Hyperactive-impulsive symptoms; LUSC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg18350739 chr11:68623251 NA -0.36 -6.43 -0.33 4.41e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7829975 0.617 rs4841072 chr8:8791253 C/A cg08975724 chr8:8085496 FLJ10661 -0.46 -7.14 -0.36 6.03e-12 Mood instability; LUSC cis rs3859192 0.561 rs34453912 chr17:38180352 T/A cg17344932 chr17:38183730 MED24;SNORD124 0.72 12.87 0.58 4.72e-31 White blood cell count; LUSC cis rs4243830 0.737 rs11122085 chr1:6597861 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.89 9.68 0.47 1.04e-19 Body mass index; LUSC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg21862992 chr11:68658383 NA -0.48 -7.81 -0.39 7.55e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.16 -0.32 2.06e-9 Bipolar disorder; LUSC trans rs853679 0.517 rs9393884 chr6:28046789 A/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.21 -0.32 1.57e-9 Depression; LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg11060661 chr22:24314208 DDT;DDTL -0.48 -6.4 -0.33 5.41e-10 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg18477163 chr1:228402036 OBSCN -0.56 -10.26 -0.49 1.21e-21 Diastolic blood pressure; LUSC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg22875332 chr1:76189707 ACADM 0.82 13.08 0.58 7.77e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg14092988 chr3:52407081 DNAH1 0.31 6.04 0.31 4.15e-9 Bipolar disorder; LUSC cis rs6504663 0.558 rs2412325 chr17:48546232 G/C cg03168497 chr17:48586147 MYCBPAP 0.47 6.31 0.33 8.66e-10 Visceral fat; LUSC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg04414720 chr1:150670196 GOLPH3L -0.4 -6.1 -0.32 2.96e-9 Tonsillectomy; LUSC cis rs4499344 0.633 rs259251 chr19:33149768 G/A cg22980127 chr19:33182716 NUDT19 -0.44 -6.45 -0.33 3.88e-10 Mean platelet volume; LUSC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg10792982 chr14:105748885 BRF1 0.48 8.71 0.43 1.44e-16 Mean platelet volume;Platelet distribution width; LUSC trans rs9650657 0.644 rs4395858 chr8:10521021 C/T cg15556689 chr8:8085844 FLJ10661 0.43 6.11 0.32 2.7e-9 Neuroticism; LUSC cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg26924012 chr15:45694286 SPATA5L1 1.12 20.31 0.74 2.75e-60 Homoarginine levels; LUSC trans rs953492 0.644 rs4634890 chr1:243390825 A/C cg25284624 chr1:224180302 NA -0.41 -6.19 -0.32 1.72e-9 Diastolic blood pressure; LUSC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg16928487 chr17:17741425 SREBF1 -0.42 -8.21 -0.41 4.86e-15 Total body bone mineral density; LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg05165339 chr4:1420672 NA -0.29 -6.46 -0.33 3.77e-10 Longevity; LUSC cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.49 -7.01 -0.36 1.34e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs72634258 0.842 rs6668846 chr1:8152102 C/G cg26816564 chr1:7831052 VAMP3 -0.43 -5.69 -0.3 2.82e-8 Inflammatory bowel disease; LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC cis rs17286411 0.750 rs4788450 chr16:71955400 T/G cg03805757 chr16:71968109 PKD1L3 0.43 7.02 0.36 1.23e-11 Blood protein levels; LUSC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.46 -7.61 -0.38 2.75e-13 Schizophrenia; LUSC cis rs4718428 1.000 rs1830070 chr7:66349671 T/C cg11764359 chr7:65958608 NA 0.44 6.3 0.33 9.25e-10 Corneal structure; LUSC trans rs3733585 0.673 rs116046986 chr4:9957794 A/G cg26043149 chr18:55253948 FECH -0.45 -6.87 -0.35 3.23e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7599312 0.534 rs2128321 chr2:213405276 G/T cg16329650 chr2:213403929 ERBB4 0.86 18.99 0.72 4.68e-55 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg03647239 chr10:116582469 FAM160B1 0.47 7.58 0.38 3.42e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2559856 0.935 rs7970952 chr12:102081577 C/T cg12924262 chr12:102091054 CHPT1 0.42 5.7 0.3 2.67e-8 Blood protein levels; LUSC cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.42 -0.33 4.6e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14442939 chr10:27389572 ANKRD26 0.9 9.51 0.46 3.81e-19 Breast cancer; LUSC cis rs10191773 0.589 rs6761440 chr2:112959193 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.75 7.6 0.38 2.93e-13 Yeast infection; LUSC cis rs56399783 0.901 rs73051444 chr7:2866529 G/A cg19731401 chr7:2775893 GNA12 0.69 9.87 0.48 2.45e-20 Childhood ear infection; LUSC cis rs11247915 0.561 rs12750420 chr1:26608649 G/A cg15628303 chr1:26608928 UBXN11 0.49 8.0 0.4 2.01e-14 Obesity-related traits; LUSC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Vitiligo; LUSC cis rs7523050 0.643 rs67091034 chr1:109402567 C/G cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs7726839 0.540 rs72703079 chr5:595173 T/C cg25482853 chr8:67687455 SGK3 1.12 16.14 0.66 1.01e-43 Obesity-related traits; LUSC cis rs6762 0.748 rs3059 chr11:840319 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.52 -7.15 -0.36 5.45e-12 Mean platelet volume; LUSC cis rs11637445 0.677 rs3784713 chr15:68073013 C/T cg08079166 chr15:68083412 MAP2K5 0.36 7.39 0.37 1.17e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg07777115 chr5:623756 CEP72 -0.47 -5.86 -0.31 1.11e-8 Obesity-related traits; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg07677032 chr17:61819896 STRADA -0.51 -8.6 -0.43 3.12e-16 Prudent dietary pattern; LUSC cis rs117623576 0.941 rs16932939 chr10:32407862 T/C cg03047570 chr10:32398778 NA -0.64 -6.8 -0.35 4.8e-11 Anti-saccade response; LUSC cis rs9303401 0.614 rs62084387 chr17:57148027 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.84 11.97 0.55 1.01e-27 Cognitive test performance; LUSC cis rs11098499 0.691 rs9995716 chr4:120264996 T/C cg24375607 chr4:120327624 NA 0.7 11.14 0.52 9.78e-25 Corneal astigmatism; LUSC trans rs3785574 0.962 rs57553639 chr17:61848499 C/T cg09060275 chr22:27053596 MIAT -0.4 -6.03 -0.31 4.45e-9 Height; LUSC trans rs1864729 0.901 rs1348184 chr8:98276912 C/G cg08679828 chr8:102218111 ZNF706 -0.87 -7.83 -0.39 6.43e-14 Estradiol plasma levels (breast cancer); LUSC cis rs727505 1.000 rs2402751 chr7:124434760 C/T cg23710748 chr7:124431027 NA -0.41 -6.98 -0.36 1.62e-11 Lewy body disease; LUSC cis rs6460942 0.591 rs75804221 chr7:12364319 C/T cg06484146 chr7:12443880 VWDE -0.6 -6.37 -0.33 6.2e-10 Coronary artery disease; LUSC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg19812747 chr11:111475976 SIK2 -0.55 -8.18 -0.41 5.92e-15 Primary sclerosing cholangitis; LUSC cis rs7095944 0.614 rs10901817 chr10:126443404 A/T cg08799069 chr10:126477246 METTL10 -0.41 -6.31 -0.33 9.12e-10 Asthma; LUSC cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg12826209 chr6:26865740 GUSBL1 0.77 8.94 0.44 2.74e-17 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.745 rs6601569 chr8:11073578 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.35 -0.37 1.53e-12 Triglycerides; LUSC trans rs853679 0.517 rs9380059 chr6:28132358 A/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs4865169 0.871 rs9918067 chr4:57870544 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.38 -5.76 -0.3 1.93e-8 Breast cancer; LUSC cis rs9581857 0.547 rs9319374 chr13:28047587 A/C cg22138327 chr13:27999177 GTF3A 0.73 7.89 0.4 4.26e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC trans rs3733585 0.673 rs7376505 chr4:9952744 C/A cg26043149 chr18:55253948 FECH -0.45 -6.86 -0.35 3.42e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7216064 1.000 rs8079754 chr17:65887896 A/G cg12091567 chr17:66097778 LOC651250 -0.7 -8.97 -0.44 2.1e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg00254258 chr1:3105189 PRDM16 -0.29 -5.7 -0.3 2.66e-8 Migraine; LUSC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg09359103 chr1:154839909 KCNN3 -0.69 -15.99 -0.66 3.74e-43 Prostate cancer; LUSC cis rs3741798 1.000 rs61922028 chr12:12487096 A/C cg08615371 chr12:12503544 MANSC1 1.09 11.13 0.52 1.13e-24 Cerebrospinal fluid biomarker levels; LUSC cis rs73198271 0.515 rs11774722 chr8:8642448 T/C cg01851573 chr8:8652454 MFHAS1 0.62 6.84 0.35 3.78e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg15448220 chr1:150897856 SETDB1 0.39 5.76 0.3 1.95e-8 Melanoma; LUSC cis rs796364 0.760 rs11690371 chr2:200989616 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.98 -0.4 2.44e-14 Schizophrenia; LUSC cis rs68092024 0.731 rs792841 chr3:99471308 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.35 -6.85 -0.35 3.5e-11 Cleft lip with or without cleft palate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23704733 chr4:84031142 PLAC8 -0.42 -6.23 -0.32 1.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6460942 0.524 rs6948366 chr7:12369905 A/G cg06484146 chr7:12443880 VWDE -0.51 -6.29 -0.33 1.01e-9 Coronary artery disease; LUSC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg06634786 chr22:41940651 POLR3H 0.51 6.05 0.31 3.96e-9 Vitiligo; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13980399 chr14:61447827 SLC38A6;TRMT5 0.76 6.1 0.32 2.92e-9 Cognitive performance; LUSC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg14830002 chr1:247616686 OR2B11 0.45 6.86 0.35 3.32e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs2777491 1.000 rs316609 chr15:41743828 T/A cg18705301 chr15:41695430 NDUFAF1 -0.7 -12.78 -0.57 1.0500000000000001e-30 Ulcerative colitis; LUSC cis rs4478858 0.735 rs12734617 chr1:31823446 G/T cg00250761 chr1:31883323 NA -0.38 -9.14 -0.45 6.41e-18 Alcohol dependence; LUSC cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg10802521 chr3:52805072 NEK4 -0.52 -8.42 -0.42 1.09e-15 Bipolar disorder; LUSC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg23985595 chr17:80112537 CCDC57 -0.31 -6.13 -0.32 2.41e-9 Life satisfaction; LUSC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.84 0.51 1.17e-23 Menopause (age at onset); LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg02018176 chr4:1364513 KIAA1530 0.51 8.78 0.43 8.6e-17 Obesity-related traits; LUSC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg01616529 chr11:638424 DRD4 -0.34 -5.8 -0.3 1.58e-8 Systemic lupus erythematosus; LUSC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg14552801 chr7:65878734 NA -0.37 -5.73 -0.3 2.19e-8 Aortic root size; LUSC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg08847533 chr14:75593920 NEK9 0.84 15.64 0.65 9.26e-42 Height; LUSC trans rs7647973 0.710 rs6797299 chr3:49609794 G/T cg21659725 chr3:3221576 CRBN -0.71 -7.82 -0.39 7.08e-14 Menarche (age at onset); LUSC cis rs9905704 0.846 rs304268 chr17:56799907 T/C cg12560992 chr17:57184187 TRIM37 0.58 8.4 0.42 1.34e-15 Testicular germ cell tumor; LUSC cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.82 0.3 1.39e-8 Breast cancer; LUSC cis rs9902453 0.904 rs55866125 chr17:28312993 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.5 0.5 1.84e-22 Coffee consumption (cups per day); LUSC cis rs7618501 1.000 rs11709680 chr3:49745188 C/T cg13072238 chr3:49761600 GMPPB -0.38 -6.25 -0.32 1.28e-9 Intelligence (multi-trait analysis); LUSC trans rs1998174 0.509 rs4916403 chr1:171815963 T/C cg13482142 chr2:234261155 NA 0.41 6.05 0.31 3.83e-9 Platelet distribution width; LUSC cis rs10838532 0.506 rs11038739 chr11:46017895 A/T cg24204282 chr11:45944920 GYLTL1B 0.44 5.82 0.3 1.35e-8 Axial length; LUSC trans rs75804782 0.520 rs72987319 chr2:239351143 C/T cg01134436 chr17:81009848 B3GNTL1 0.66 6.28 0.32 1.02e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs4595586 0.545 rs12823721 chr12:39386461 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs10751667 0.643 rs7396951 chr11:927355 G/A ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs7927592 0.913 rs3740629 chr11:68343593 C/T cg20283391 chr11:68216788 NA -0.6 -8.38 -0.42 1.53e-15 Total body bone mineral density; LUSC cis rs829883 0.622 rs7302630 chr12:98959577 C/A cg25150519 chr12:98850993 NA -0.62 -8.53 -0.42 5.13e-16 Colorectal adenoma (advanced); LUSC cis rs1371867 0.875 rs962451 chr8:101331010 C/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.44 -0.38 8.44e-13 Atrioventricular conduction; LUSC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg05084668 chr3:125655381 ALG1L -0.49 -6.86 -0.35 3.26e-11 Blood pressure (smoking interaction); LUSC cis rs6537837 0.793 rs12023963 chr1:110084827 A/G cg05049280 chr1:110155535 GNAT2 -0.37 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg04546413 chr19:29218101 NA 0.71 11.42 0.53 1.02e-25 Methadone dose in opioid dependence; LUSC cis rs6977660 0.714 rs28605851 chr7:19815219 G/A cg05791153 chr7:19748676 TWISTNB 0.7 7.45 0.38 8.29e-13 Thyroid stimulating hormone; LUSC cis rs9921222 0.509 rs3743883 chr16:404750 T/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.67 12.06 0.55 4.76e-28 Bone mineral density (spine);Bone mineral density; LUSC cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg23601095 chr6:26197514 HIST1H3D 0.68 7.42 0.38 9.69e-13 Gout;Renal underexcretion gout; LUSC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.75 0.43 1.09e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs10754283 0.967 rs7546518 chr1:90109956 C/T cg21401794 chr1:90099060 LRRC8C 0.64 9.49 0.46 4.38e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12950390 0.853 rs67441169 chr17:45854462 T/G cg03474202 chr17:45855739 NA -0.29 -6.62 -0.34 1.44e-10 IgG glycosylation; LUSC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg09359103 chr1:154839909 KCNN3 -0.69 -15.99 -0.66 3.74e-43 Prostate cancer; LUSC cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg14835575 chr10:16859367 RSU1 0.77 9.72 0.47 7.81e-20 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg01982873 chr5:490308 SLC9A3 -0.35 -6.2 -0.32 1.69e-9 Cystic fibrosis severity; LUSC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg22467129 chr15:76604101 ETFA -0.52 -8.38 -0.42 1.46e-15 Blood metabolite levels; LUSC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg11764359 chr7:65958608 NA -0.51 -6.51 -0.34 2.74e-10 Aortic root size; LUSC cis rs9399135 0.935 rs9376086 chr6:135371329 T/C cg24558204 chr6:135376177 HBS1L 0.58 9.03 0.44 1.38e-17 Red blood cell count; LUSC cis rs62400317 0.859 rs11965520 chr6:45259431 T/A cg20913747 chr6:44695427 NA -0.46 -7.49 -0.38 6.09e-13 Total body bone mineral density; LUSC trans rs1005277 0.579 rs1780138 chr10:38501654 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.5 -0.46 4.09e-19 Extrinsic epigenetic age acceleration; LUSC trans rs7829975 0.688 rs7826654 chr8:8379106 C/T cg27411982 chr8:10470053 RP1L1 0.45 7.51 0.38 5.53e-13 Mood instability; LUSC trans rs3733585 0.605 rs4697926 chr4:10124567 G/T cg26043149 chr18:55253948 FECH 0.51 7.56 0.38 3.8e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg23719950 chr11:63933701 MACROD1 -0.38 -5.93 -0.31 7.6e-9 Platelet count; LUSC trans rs9380880 0.826 rs12198307 chr6:39550197 C/T cg12580580 chr10:74544059 CCDC109A 0.59 6.68 0.34 9.96e-11 Immune response to smallpox vaccine (IL-6); LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg08517562 chr20:49126905 PTPN1 -0.4 -6.0 -0.31 5.14e-9 QT interval (ambient particulate matter interaction); LUSC cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg05535760 chr7:792225 HEATR2 0.75 9.04 0.44 1.27e-17 Cerebrospinal P-tau181p levels; LUSC cis rs208515 0.525 rs10944868 chr6:66687508 A/G cg07460842 chr6:66804631 NA 1.02 14.11 0.61 8.54e-36 Exhaled nitric oxide levels; LUSC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg01802117 chr1:53393560 SCP2 0.39 6.31 0.33 8.82e-10 Monocyte count; LUSC trans rs4596713 0.508 rs4745650 chr9:71777892 G/A cg25283916 chr1:242222868 NA -0.29 -6.0 -0.31 5.05e-9 Headache; LUSC cis rs62400317 0.762 rs3997499 chr6:44864552 G/T cg20913747 chr6:44695427 NA -0.48 -7.44 -0.38 8.79e-13 Total body bone mineral density; LUSC trans rs8073060 0.559 rs17550632 chr17:33890883 G/C cg19694781 chr19:47549865 TMEM160 1.15 18.27 0.71 3.51e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1150668 0.796 rs1124132 chr6:28380321 T/G cg21251018 chr6:28226885 NKAPL 0.3 5.72 0.3 2.4e-8 Pubertal anthropometrics; LUSC cis rs9303401 0.625 rs34963822 chr17:56988424 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.12 0.58 5.34e-32 Cognitive test performance; LUSC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs6929568 0.966 rs537368 chr6:8213872 A/G cg05398487 chr6:8064678 MUTED 0.42 5.92 0.31 7.94e-9 Coronary artery calcification; LUSC cis rs10886558 0.619 rs10886564 chr10:121762869 C/T cg02041677 chr10:121771263 NA -0.34 -5.72 -0.3 2.31e-8 Shingles; LUSC cis rs7715806 0.500 rs17563700 chr5:74986045 A/G cg19683494 chr5:74908142 NA 0.59 8.05 0.4 1.48e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs12310956 0.532 rs11494810 chr12:33952881 C/A cg13010199 chr12:38710504 ALG10B 0.53 7.91 0.4 3.75e-14 Morning vs. evening chronotype; LUSC cis rs7216064 0.953 rs4791048 chr17:65848994 G/A cg12091567 chr17:66097778 LOC651250 -0.72 -9.53 -0.46 3.46e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs4332037 0.506 rs62442924 chr7:1989976 C/T cg23422044 chr7:1970798 MAD1L1 -0.54 -6.03 -0.31 4.24e-9 Bipolar disorder; LUSC cis rs66716358 0.744 rs10769036 chr11:44321508 C/A cg16977035 chr11:44330474 ALX4 0.35 5.8 0.3 1.52e-8 Monobrow; LUSC trans rs637571 0.510 rs10896052 chr11:65579600 C/A cg17712092 chr4:129076599 LARP1B -0.71 -10.22 -0.49 1.65e-21 Eosinophil percentage of white cells; LUSC cis rs7759001 0.857 rs9461378 chr6:27360245 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.77e-8 Glomerular filtration rate (creatinine); LUSC cis rs6961069 0.742 rs1722502 chr7:80241874 A/C cg04458919 chr7:80252533 CD36 -0.36 -6.63 -0.34 1.32e-10 Platelet count; LUSC cis rs12310956 0.532 rs11052920 chr12:33955891 T/G cg06521331 chr12:34319734 NA -0.45 -7.33 -0.37 1.77e-12 Morning vs. evening chronotype; LUSC cis rs6582630 0.576 rs2222345 chr12:38356020 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.69 -0.34 9.33e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs7180079 1.000 rs11855072 chr15:64538524 C/T cg08069370 chr15:64387884 SNX1 -0.56 -5.87 -0.31 1.02e-8 Monocyte count; LUSC cis rs1559088 0.744 rs12972060 chr19:33537096 C/T cg27124370 chr19:33622961 WDR88 -0.5 -6.62 -0.34 1.42e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg20933634 chr6:27740509 NA -0.44 -5.79 -0.3 1.61e-8 Parkinson's disease; LUSC trans rs3857536 0.730 rs7761295 chr6:66932532 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs11048434 0.736 rs2041624 chr12:9111855 C/G cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC cis rs7267979 1.000 rs2258201 chr20:25272490 G/C cg08601574 chr20:25228251 PYGB 0.43 6.53 0.34 2.4e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10207060 0.500 rs11884577 chr2:240702216 C/G cg07506560 chr2:240697449 NA 0.45 6.92 0.35 2.25e-11 Obesity-related traits; LUSC trans rs3733585 0.699 rs6449179 chr4:9969117 G/A cg26043149 chr18:55253948 FECH -0.46 -7.11 -0.36 7.02e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12681287 0.640 rs13261901 chr8:87478717 G/C cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg08470875 chr2:26401718 FAM59B -0.65 -8.6 -0.43 3.12e-16 Gut microbiome composition (summer); LUSC cis rs4631830 0.896 rs7077830 chr10:51522276 C/G cg10326726 chr10:51549505 MSMB 0.33 5.7 0.3 2.66e-8 Prostate-specific antigen levels; LUSC cis rs9467773 1.000 rs10946834 chr6:26533664 G/C cg05738196 chr6:26577821 NA 0.82 15.82 0.65 1.9e-42 Intelligence (multi-trait analysis); LUSC cis rs9815354 0.812 rs76966288 chr3:41825055 G/A cg03022575 chr3:42003672 ULK4 0.85 8.67 0.43 1.9e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs17102423 0.826 rs10873182 chr14:65605408 C/T cg11161011 chr14:65562177 MAX -0.71 -10.96 -0.51 4.27e-24 Obesity-related traits; LUSC cis rs2070488 0.775 rs2268762 chr3:38516075 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 12.35 0.56 4.15e-29 Electrocardiographic conduction measures; LUSC cis rs2479724 0.840 rs6925777 chr6:41750822 C/T cg17623882 chr6:41773611 USP49 0.65 10.72 0.51 2.94e-23 Menarche (age at onset); LUSC trans rs2727020 0.553 rs11040400 chr11:49518296 C/A cg15704280 chr7:45808275 SEPT13 -1.07 -20.42 -0.75 9.87e-61 Coronary artery disease; LUSC cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg00012203 chr2:219082015 ARPC2 -0.78 -13.95 -0.61 3.62e-35 Colorectal cancer; LUSC cis rs2274273 0.840 rs6573020 chr14:55871452 C/T cg04306507 chr14:55594613 LGALS3 0.56 12.74 0.57 1.44e-30 Protein biomarker; LUSC cis rs174479 0.677 rs1000778 chr11:61655305 A/G cg01500311 chr11:61656094 FADS3 0.39 6.7 0.34 8.66e-11 Sphingolipid levels; LUSC cis rs12410462 0.581 rs73102371 chr1:227554880 G/A cg23173402 chr1:227635558 NA 0.52 6.08 0.32 3.26e-9 Major depressive disorder; LUSC cis rs34311866 0.752 rs11725653 chr4:963397 C/T cg07828340 chr4:882639 GAK 0.98 10.03 0.48 7.38e-21 Parkinson's disease; LUSC cis rs10208940 0.920 rs10164780 chr2:68766250 A/T cg12452813 chr2:68675892 NA 0.58 5.96 0.31 6.45e-9 Urate levels in lean individuals; LUSC cis rs7582180 0.663 rs1114595 chr2:100960072 T/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.69 -0.43 1.66e-16 Intelligence (multi-trait analysis); LUSC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg11645453 chr3:52864694 ITIH4 0.28 6.58 0.34 1.82e-10 Electroencephalogram traits; LUSC cis rs11997175 0.574 rs4733456 chr8:33656359 C/T ch.8.33884649F chr8:33765107 NA 0.53 8.65 0.43 2.18e-16 Body mass index; LUSC cis rs2677744 0.688 rs3784779 chr15:91453131 C/T cg23684204 chr15:91497937 RCCD1 0.46 6.53 0.34 2.45e-10 Attention deficit hyperactivity disorder; LUSC cis rs7089973 0.604 rs765174 chr10:116601888 C/T cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7131987 0.868 rs11050151 chr12:29403008 T/A cg09582351 chr12:29534625 ERGIC2 -0.32 -6.74 -0.35 7.07e-11 QT interval; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22366698 chr11:3400543 ZNF195 0.52 7.83 0.39 6.33e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs17039065 1.000 rs12502981 chr4:109392960 G/A cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.24e-10 Gut microbiome composition (summer); LUSC cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg21535247 chr6:8435926 SLC35B3 0.6 9.37 0.46 1.13e-18 Motion sickness; LUSC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg13902645 chr11:5959945 NA -0.59 -8.28 -0.41 3.1e-15 DNA methylation (variation); LUSC trans rs9929218 0.551 rs9888942 chr16:68727572 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.09 24.72 0.8 2.06e-77 Colorectal cancer; LUSC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg21775007 chr8:11205619 TDH -0.46 -6.91 -0.35 2.4e-11 Neuroticism; LUSC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg11247378 chr22:39784982 NA -0.63 -12.21 -0.56 1.34e-28 Intelligence (multi-trait analysis); LUSC cis rs807669 0.903 rs807668 chr22:19162686 A/G cg02655711 chr22:19163373 SLC25A1 0.89 17.81 0.7 2.27e-50 Metabolite levels; LUSC cis rs1609391 0.561 rs6439675 chr3:136625436 G/A cg15507776 chr3:136538369 TMEM22 0.51 8.39 0.42 1.37e-15 Neuroticism; LUSC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg23283495 chr1:209979779 IRF6 -0.65 -7.98 -0.4 2.4e-14 Coronary artery disease; LUSC cis rs8062405 0.754 rs151179 chr16:28487056 A/G cg16576597 chr16:28551801 NUPR1 0.29 5.9 0.31 8.68e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4595586 0.545 rs1356265 chr12:39403696 A/G cg13010199 chr12:38710504 ALG10B 0.39 5.76 0.3 1.93e-8 Morning vs. evening chronotype; LUSC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.35 5.66 0.3 3.2e-8 Menopause (age at onset); LUSC cis rs6977660 0.652 rs4721826 chr7:19823804 T/C cg05791153 chr7:19748676 TWISTNB 0.67 6.98 0.36 1.55e-11 Thyroid stimulating hormone; LUSC cis rs68170813 0.559 rs17428071 chr7:106878200 C/G cg02696742 chr7:106810147 HBP1 -0.64 -9.58 -0.46 2.35e-19 Coronary artery disease; LUSC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11890956 chr21:40555474 PSMG1 0.73 11.86 0.54 2.56e-27 Cognitive function; LUSC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.59 7.93 0.4 3.38e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs1348850 0.789 rs13027959 chr2:178275887 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 7.22 0.37 3.48e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs654950 0.807 rs61773660 chr1:41993298 C/T cg06885757 chr1:42089581 HIVEP3 -0.4 -7.76 -0.39 1.05e-13 Airway imaging phenotypes; LUSC cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.73 12.98 0.58 1.82e-31 Personality dimensions; LUSC cis rs28735056 0.967 rs623546 chr18:77595228 C/T cg20368463 chr18:77673604 PQLC1 -0.55 -7.78 -0.39 9.16e-14 Schizophrenia; LUSC cis rs11758351 1.000 rs78012445 chr6:26195080 G/C cg01420254 chr6:26195488 NA 0.7 7.46 0.38 7.56e-13 Gout;Renal underexcretion gout; LUSC trans rs634534 0.622 rs501353 chr11:65739549 T/G cg17712092 chr4:129076599 LARP1B 0.74 11.32 0.53 2.39e-25 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.35 0.37 1.57e-12 Bipolar disorder; LUSC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg20283391 chr11:68216788 NA -0.52 -7.74 -0.39 1.18e-13 Total body bone mineral density; LUSC cis rs6459788 0.934 rs10237947 chr7:157258109 G/T cg03453431 chr7:157225567 NA 0.51 8.77 0.43 9.45e-17 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg17143192 chr8:8559678 CLDN23 0.63 9.0 0.44 1.72e-17 Obesity-related traits; LUSC cis rs7666738 0.512 rs1648536 chr4:99019881 G/T cg05340658 chr4:99064831 C4orf37 -0.45 -7.14 -0.36 5.8e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.84 -0.44 5.55e-17 Monocyte percentage of white cells; LUSC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg06558623 chr16:89946397 TCF25 1.08 9.33 0.45 1.49e-18 Skin colour saturation; LUSC cis rs2439831 1.000 rs471229 chr15:43733994 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.81 8.1 0.41 1.02e-14 Lung cancer in ever smokers; LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.05 -0.31 3.99e-9 Developmental language disorder (linguistic errors); LUSC trans rs7615952 1.000 rs7615952 chr3:125649403 A/C cg07211511 chr3:129823064 LOC729375 1.22 20.96 0.75 7.24e-63 Blood pressure (smoking interaction); LUSC cis rs12618769 0.597 rs3769723 chr2:99105988 A/G cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC trans rs7937682 0.924 rs875258 chr11:111530607 C/A cg18187862 chr3:45730750 SACM1L 0.55 7.09 0.36 8.01e-12 Primary sclerosing cholangitis; LUSC cis rs4953318 0.577 rs67087783 chr2:46363544 C/T cg12428440 chr2:46370979 PRKCE 0.46 7.61 0.38 2.86e-13 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs11122272 0.735 rs2808580 chr1:231509259 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg16325326 chr1:53192061 ZYG11B 0.97 18.75 0.72 4.37e-54 Monocyte count; LUSC cis rs7267979 0.816 rs6115094 chr20:25210827 A/G cg08601574 chr20:25228251 PYGB 0.55 8.76 0.43 9.9900000000000006e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7043114 0.507 rs10992291 chr9:95033009 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.32 -0.33 8.32e-10 Height; LUSC cis rs1595825 0.627 rs78002594 chr2:198467113 A/T cg00982548 chr2:198649783 BOLL -0.51 -5.96 -0.31 6.33e-9 Ulcerative colitis; LUSC cis rs2625529 0.824 rs16953769 chr15:72463325 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.49 -0.38 6.36e-13 Red blood cell count; LUSC cis rs3820928 0.900 rs6754155 chr2:227784961 A/G cg11843606 chr2:227700838 RHBDD1 -0.55 -8.01 -0.4 1.99e-14 Pulmonary function; LUSC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.8 -0.35 4.84e-11 Total body bone mineral density; LUSC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg15839431 chr19:19639596 YJEFN3 -0.41 -5.72 -0.3 2.37e-8 Tonsillectomy; LUSC cis rs9527 0.615 rs10883781 chr10:104581130 A/G cg15744005 chr10:104629667 AS3MT -0.3 -5.7 -0.3 2.62e-8 Arsenic metabolism; LUSC cis rs6121246 0.609 rs6060627 chr20:30262159 C/T cg13852791 chr20:30311386 BCL2L1 0.97 15.03 0.64 2.25e-39 Mean corpuscular hemoglobin; LUSC cis rs11098499 0.955 rs35434465 chr4:120169378 C/G cg24375607 chr4:120327624 NA 0.74 11.02 0.52 2.59e-24 Corneal astigmatism; LUSC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.66 14.48 0.62 3.29e-37 Hemoglobin concentration; LUSC cis rs3767633 0.528 rs6671373 chr1:161890796 C/G cg27519958 chr1:161735129 ATF6 -0.43 -7.09 -0.36 8.08e-12 IgG glycosylation; LUSC cis rs4786125 0.769 rs4129042 chr16:6901398 G/T cg03623568 chr16:6915990 A2BP1 0.4 6.24 0.32 1.3e-9 Heart rate variability traits (SDNN); LUSC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 9.77 0.47 5.33e-20 Eosinophil percentage of white cells; LUSC cis rs75229567 0.618 rs11177849 chr12:70182473 C/T cg10114359 chr12:70132523 RAB3IP -1.31 -12.14 -0.55 2.48e-28 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs7771547 0.519 rs2057351 chr6:36361682 G/A cg07856975 chr6:36356162 ETV7 0.44 6.66 0.34 1.13e-10 Platelet distribution width; LUSC cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg06784218 chr1:46089804 CCDC17 0.53 10.32 0.49 7.66e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.6 8.84 0.44 5.69e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9325144 0.555 rs7301258 chr12:38706942 C/T cg26384229 chr12:38710491 ALG10B 0.6 9.27 0.45 2.29e-18 Morning vs. evening chronotype; LUSC trans rs11039798 0.623 rs6485879 chr11:48587984 G/T cg15704280 chr7:45808275 SEPT13 0.66 7.28 0.37 2.46e-12 Axial length; LUSC trans rs6502050 0.842 rs9894129 chr17:80075700 A/G cg07393940 chr7:158741817 NA -0.37 -6.54 -0.34 2.29e-10 Life satisfaction; LUSC cis rs9921222 0.509 rs3743883 chr16:404750 T/C cg00101154 chr16:420108 MRPL28 -0.4 -6.37 -0.33 6.43e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs7954584 0.635 rs3847694 chr12:122325820 A/G cg22618164 chr12:122356400 WDR66 0.57 8.61 0.43 2.93e-16 Mean corpuscular volume; LUSC cis rs7481584 0.581 rs399565 chr11:3061780 C/T cg08508325 chr11:3079039 CARS 0.38 8.66 0.43 2.05e-16 Calcium levels; LUSC cis rs7296418 0.738 rs10846489 chr12:123743927 A/G cg13010344 chr12:123464640 ARL6IP4 0.49 7.94 0.4 3.05e-14 Platelet count; LUSC cis rs28785552 0.931 rs10406850 chr19:53240807 A/C cg10871876 chr19:53194124 ZNF83 0.57 8.81 0.43 7.07e-17 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs9527 0.590 rs11191540 chr10:104822809 G/C cg04362960 chr10:104952993 NT5C2 0.62 9.62 0.47 1.71e-19 Arsenic metabolism; LUSC cis rs763121 0.815 rs9306328 chr22:39028913 C/T cg06022373 chr22:39101656 GTPBP1 0.73 11.94 0.55 1.27e-27 Menopause (age at onset); LUSC cis rs6961069 0.585 rs1722506 chr7:80238852 A/G cg04458919 chr7:80252533 CD36 -0.4 -7.32 -0.37 1.91e-12 Platelet count; LUSC cis rs7824557 0.767 rs28507159 chr8:11166076 C/T cg27411982 chr8:10470053 RP1L1 0.38 5.96 0.31 6.51e-9 Retinal vascular caliber; LUSC cis rs7804356 1.000 rs3823938 chr7:26853741 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.16 -0.32 2.1e-9 Type 1 diabetes; LUSC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg00012203 chr2:219082015 ARPC2 -0.87 -16.71 -0.67 5.33e-46 Colorectal cancer; LUSC cis rs13315871 1.000 rs11713214 chr3:58445991 C/T cg12435725 chr3:58293450 RPP14 -0.7 -6.93 -0.35 2.21e-11 Cholesterol, total; LUSC cis rs1808579 0.904 rs891387 chr18:21103909 A/G cg14672496 chr18:21087552 C18orf8 0.4 6.62 0.34 1.42e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs12780046 0.505 rs2862553 chr10:101048492 C/T cg27143070 chr10:101087766 CNNM1 0.37 5.67 0.3 3.13e-8 Non-glioblastoma glioma; LUSC cis rs11264799 0.539 rs849825 chr1:157546762 C/T cg18268488 chr1:157545234 FCRL4 0.39 7.67 0.39 1.92e-13 IgA nephropathy; LUSC cis rs804280 0.542 rs34117651 chr8:11791617 G/C cg21775007 chr8:11205619 TDH 0.47 6.72 0.34 8.08e-11 Myopia (pathological); LUSC cis rs16854884 0.657 rs35959290 chr3:143725566 T/A cg06585982 chr3:143692056 C3orf58 0.45 6.97 0.36 1.67e-11 Economic and political preferences (feminism/equality); LUSC cis rs7192380 0.965 rs4633710 chr16:69632961 A/G cg26679644 chr16:69762563 NA 0.35 6.2 0.32 1.7e-9 Sjögren's syndrome; LUSC cis rs72772090 0.634 rs72773912 chr5:96107801 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.76 -8.58 -0.42 3.65e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs983392 0.680 rs7929589 chr11:59975078 C/T cg20284999 chr11:59952153 MS4A6A -0.37 -6.24 -0.32 1.3e-9 Alzheimer's disease (late onset); LUSC cis rs12579753 0.956 rs34747993 chr12:82217777 C/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.82 -0.3 1.34e-8 Resting heart rate; LUSC cis rs2463822 0.925 rs12292586 chr11:62156312 C/T cg06239285 chr11:62104954 ASRGL1 -0.96 -10.41 -0.49 3.72e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9311676 0.609 rs11921259 chr3:58368646 A/G cg13750441 chr3:58318267 PXK 0.36 6.91 0.35 2.51e-11 Systemic lupus erythematosus; LUSC cis rs9815354 0.812 rs73073371 chr3:41843443 A/G cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1580019 0.961 rs11768506 chr7:32494788 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.77 11.6 0.54 2.25e-26 Cognitive ability; LUSC cis rs9611519 0.894 rs13053242 chr22:41459486 G/A cg13813247 chr22:41461852 NA -0.38 -6.73 -0.35 7.55e-11 Neuroticism; LUSC cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg15997130 chr1:24165203 NA 0.51 8.21 0.41 4.74e-15 Immature fraction of reticulocytes; LUSC cis rs9837602 1.000 rs62285461 chr3:99767642 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 5.64 0.3 3.56e-8 Breast cancer; LUSC cis rs644799 0.582 rs473157 chr11:95596874 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.63 9.26 0.45 2.54e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg26441486 chr22:50317300 CRELD2 0.5 7.66 0.39 2.08e-13 Schizophrenia; LUSC cis rs886126 0.950 rs2097658 chr12:111690466 C/T cg10833066 chr12:111807467 FAM109A 0.4 6.09 0.32 3.06e-9 Coronary heart disease; LUSC cis rs9403521 0.898 rs10872562 chr6:143974930 A/G cg18240653 chr6:144019428 PHACTR2 -0.48 -5.78 -0.3 1.72e-8 Obesity-related traits; LUSC cis rs12286929 0.644 rs7942036 chr11:115078356 G/C cg04055981 chr11:115044050 NA 0.45 8.03 0.4 1.7e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg14664628 chr15:75095509 CSK -0.81 -12.54 -0.57 8.07e-30 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs7726839 0.540 rs7558 chr5:660491 C/T cg11887960 chr12:57824829 NA 0.51 6.43 0.33 4.46e-10 Obesity-related traits; LUSC cis rs6500602 0.893 rs4785962 chr16:4484328 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.48 6.21 0.32 1.59e-9 Schizophrenia; LUSC cis rs2760061 0.819 rs708120 chr1:228207651 G/C cg18477163 chr1:228402036 OBSCN 0.63 12.02 0.55 6.94e-28 Diastolic blood pressure; LUSC cis rs4664304 0.802 rs3792175 chr2:160862804 T/A cg03641300 chr2:160917029 PLA2R1 -0.37 -5.97 -0.31 5.92e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg01475377 chr6:109611718 NA -0.4 -7.08 -0.36 8.58e-12 Reticulocyte fraction of red cells; LUSC cis rs7098414 0.511 rs7899545 chr10:82150635 G/C cg01528321 chr10:82214614 TSPAN14 0.6 9.02 0.44 1.51e-17 Post bronchodilator FEV1; LUSC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg05844789 chr1:228464394 OBSCN -0.3 -5.71 -0.3 2.54e-8 Diastolic blood pressure; LUSC trans rs61931739 0.533 rs4270002 chr12:34313126 G/T cg26384229 chr12:38710491 ALG10B 0.55 8.73 0.43 1.24e-16 Morning vs. evening chronotype; LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg14789911 chr21:47582049 C21orf56 -0.39 -6.13 -0.32 2.45e-9 Testicular germ cell tumor; LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg15691649 chr6:25882328 NA 0.47 7.06 0.36 9.59e-12 Blood metabolite levels; LUSC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs3741798 1.000 rs61922052 chr12:12497620 A/G cg08615371 chr12:12503544 MANSC1 1.08 11.07 0.52 1.79e-24 Cerebrospinal fluid biomarker levels; LUSC cis rs2274273 0.686 rs66531545 chr14:55587460 T/C cg04306507 chr14:55594613 LGALS3 0.48 9.54 0.46 3.03e-19 Protein biomarker; LUSC cis rs17092148 1.000 rs2425003 chr20:33403584 G/T cg16810054 chr20:33298113 TP53INP2 0.42 6.48 0.33 3.21e-10 Neuroticism; LUSC cis rs6542838 0.641 rs4499468 chr2:99475204 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.49 -0.33 3.19e-10 Fear of minor pain; LUSC cis rs9467711 0.559 rs9348721 chr6:26485573 A/G cg09904177 chr6:26538194 HMGN4 -0.76 -6.89 -0.35 2.83e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.55 0.53 3.44e-26 Hip circumference adjusted for BMI; LUSC cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg19717773 chr7:2847554 GNA12 -0.41 -7.32 -0.37 1.89e-12 Height; LUSC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.62 -7.87 -0.4 5.08e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.38 -5.8 -0.3 1.5e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs10823500 0.777 rs10509321 chr10:71985733 A/G cg02100629 chr10:71892760 AIFM2 0.37 6.14 0.32 2.39e-9 Blood protein levels; LUSC cis rs13266463 0.858 rs13255588 chr8:143384727 C/G cg16886403 chr8:143471632 TSNARE1 0.64 8.98 0.44 1.98e-17 Schizophrenia; LUSC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg12463550 chr7:65579703 CRCP 0.49 7.11 0.36 6.92e-12 Aortic root size; LUSC cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.24e-15 Chronic sinus infection; LUSC cis rs240764 0.621 rs10457844 chr6:101196532 T/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.46 -0.33 3.65e-10 Neuroticism; LUSC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.19 -0.32 1.79e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7267979 0.932 rs928121 chr20:25534818 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.84 17.96 0.7 6.16e-51 Liver enzyme levels (alkaline phosphatase); LUSC trans rs2048656 0.605 rs7814507 chr8:9646560 G/A cg06636001 chr8:8085503 FLJ10661 0.45 6.3 0.33 9.56e-10 Schizophrenia; LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg04944784 chr2:26401820 FAM59B -0.73 -10.68 -0.5 4.23e-23 Gut microbiome composition (summer); LUSC cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg20908204 chr19:46285434 DMPK -0.46 -8.75 -0.43 1.09e-16 Coronary artery disease; LUSC cis rs7208859 0.524 rs28760584 chr17:29141017 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 7.16 0.36 5.32e-12 Personality dimensions; LUSC cis rs7705502 1.000 rs17695555 chr5:173351081 C/T cg18693985 chr5:173351052 CPEB4 -0.38 -5.97 -0.31 6.06e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9467711 0.606 rs9379852 chr6:26357278 A/G cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg11244672 chr19:19639970 YJEFN3 -0.55 -6.7 -0.34 9.01e-11 Bipolar disorder; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg01416388 chr22:39784598 NA -0.43 -7.17 -0.37 4.92e-12 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg00990874 chr7:1149470 C7orf50 -0.5 -6.34 -0.33 7.54e-10 Bronchopulmonary dysplasia; LUSC cis rs9467773 0.526 rs9348710 chr6:26360486 A/C cg09904177 chr6:26538194 HMGN4 -0.52 -8.16 -0.41 6.82e-15 Intelligence (multi-trait analysis); LUSC cis rs1878931 0.582 rs10048083 chr16:3417465 A/C cg00484396 chr16:3507460 NAT15 -0.45 -6.67 -0.34 1.06e-10 Body mass index (adult); LUSC cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg05868516 chr6:26286170 HIST1H4H 0.36 5.99 0.31 5.35e-9 Educational attainment; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg16145915 chr7:1198662 ZFAND2A -0.73 -15.32 -0.64 1.65e-40 Longevity;Endometriosis; LUSC cis rs9486715 0.867 rs2499775 chr6:97007340 C/T cg06623918 chr6:96969491 KIAA0776 -0.93 -17.6 -0.69 1.57e-49 Headache; LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.74e-21 Monocyte count; LUSC cis rs6076065 0.723 rs6132604 chr20:23342226 G/A cg11657817 chr20:23433608 CST11 0.44 8.18 0.41 6.2e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs8062405 1.000 rs62037371 chr16:28890131 C/A cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7759001 0.857 rs9468079 chr6:27346905 A/G cg18711553 chr6:27366782 ZNF391 0.41 5.95 0.31 6.67e-9 Glomerular filtration rate (creatinine); LUSC trans rs782590 0.967 rs4290693 chr2:55799991 C/G cg22328901 chr2:86333256 PTCD3;POLR1A 0.41 6.05 0.31 3.88e-9 Metabolic syndrome; LUSC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6541297 0.699 rs1555290 chr1:230294989 A/C cg05784532 chr1:230284198 GALNT2 -0.56 -6.53 -0.34 2.5e-10 Coronary artery disease; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.95 -0.44 2.56e-17 Platelet count; LUSC cis rs59698941 0.550 rs11739194 chr5:132201230 T/C cg14825688 chr5:132208181 LEAP2 -0.43 -6.41 -0.33 4.95e-10 Apolipoprotein A-IV levels; LUSC cis rs950776 0.518 rs4886572 chr15:78837452 A/G cg22563815 chr15:78856949 CHRNA5 -0.26 -6.25 -0.32 1.22e-9 Sudden cardiac arrest; LUSC cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg08085267 chr17:45401833 C17orf57 -0.41 -6.2 -0.32 1.62e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg18681998 chr4:17616180 MED28 0.85 16.06 0.66 2e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.43 0.33 4.3e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg10411590 chr13:21900810 NA 0.3 5.76 0.3 1.91e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC trans rs4714291 0.963 rs1721412 chr6:40100606 T/G cg02267698 chr19:7991119 CTXN1 0.5 7.01 0.36 1.31e-11 Strep throat; LUSC cis rs265548 0.538 rs36688 chr19:17911212 A/C cg16744531 chr19:17905626 B3GNT3 0.44 6.54 0.34 2.35e-10 Tumor biomarkers; LUSC cis rs6545883 0.525 rs1621048 chr2:61364216 C/G cg15711740 chr2:61764176 XPO1 0.37 5.8 0.3 1.5e-8 Tuberculosis; LUSC cis rs2274273 0.623 rs1187881 chr14:55489197 G/A cg04306507 chr14:55594613 LGALS3 -0.5 -10.62 -0.5 6.77e-23 Protein biomarker; LUSC cis rs4654899 0.865 rs6671056 chr1:21488610 G/A cg02927042 chr1:21476669 EIF4G3 -0.36 -5.69 -0.3 2.82e-8 Superior frontal gyrus grey matter volume; LUSC cis rs926938 0.527 rs360670 chr1:115482386 G/A cg01522456 chr1:115632236 TSPAN2 -0.41 -6.41 -0.33 5.03e-10 Autism; LUSC cis rs9527 0.615 rs12248123 chr10:104735366 A/G cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.46 1.36e-18 Arsenic metabolism; LUSC cis rs9916302 0.904 rs1619021 chr17:37739274 G/A cg07936489 chr17:37558343 FBXL20 -0.67 -8.89 -0.44 3.8e-17 Glomerular filtration rate (creatinine); LUSC cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg00012203 chr2:219082015 ARPC2 -0.82 -15.72 -0.65 4.35e-42 Colorectal cancer; LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg00149659 chr3:10157352 C3orf10 0.91 12.92 0.58 3.1e-31 Alzheimer's disease; LUSC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs711245 0.702 rs1110127 chr2:36768456 G/C cg01206211 chr2:36825736 FEZ2 0.48 9.47 0.46 5.3e-19 Height; LUSC cis rs1534166 0.647 rs13321680 chr3:133507119 G/T cg08048268 chr3:133502702 NA 0.35 6.26 0.32 1.19e-9 Alcohol consumption (transferrin glycosylation); LUSC cis rs71386921 1 rs71386921 chr10:27478698 AAT/A cg14442939 chr10:27389572 ANKRD26 0.92 10.89 0.51 7.59e-24 Breast cancer; LUSC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg17279839 chr7:150038598 RARRES2 0.4 6.27 0.32 1.14e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs7208859 0.524 rs73988172 chr17:29086332 A/C cg13385521 chr17:29058706 SUZ12P 0.7 7.08 0.36 8.63e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs950169 0.840 rs12905223 chr15:85114268 T/C cg17173187 chr15:85201210 NMB 0.35 6.3 0.33 9.27e-10 Schizophrenia; LUSC cis rs11997175 0.568 rs4733169 chr8:33581855 T/C ch.8.33884649F chr8:33765107 NA 0.39 6.06 0.31 3.59e-9 Body mass index; LUSC trans rs7939886 0.920 rs12223014 chr11:55878290 G/A cg03929089 chr4:120376271 NA 0.72 6.03 0.31 4.43e-9 Myopia (pathological); LUSC cis rs10484885 0.571 rs76955220 chr6:90252030 A/G cg13799429 chr6:90582589 CASP8AP2 -0.57 -5.84 -0.3 1.23e-8 QRS interval (sulfonylurea treatment interaction); LUSC cis rs11785400 1.000 rs6997771 chr8:143747752 T/G cg10596483 chr8:143751796 JRK 0.6 9.28 0.45 2.21e-18 Schizophrenia; LUSC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg02428538 chr16:24856791 SLC5A11 -0.56 -6.19 -0.32 1.79e-9 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.863 rs3775841 chr4:120425777 A/C cg09307838 chr4:120376055 NA 0.75 10.87 0.51 9.01e-24 Corneal astigmatism; LUSC cis rs9467773 0.587 rs3208733 chr6:26414425 C/T cg09904177 chr6:26538194 HMGN4 -0.55 -8.41 -0.42 1.2e-15 Intelligence (multi-trait analysis); LUSC cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.1 0.55 3.37e-28 Colorectal cancer; LUSC cis rs10791097 0.694 rs10894273 chr11:130742155 G/T cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.23 -0.32 1.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7100689 0.646 rs11202724 chr10:82136190 T/C cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg09035930 chr12:129282057 SLC15A4 0.66 13.35 0.59 7.04e-33 Systemic lupus erythematosus; LUSC cis rs12421382 0.636 rs1371329 chr11:109382725 G/T cg27471124 chr11:109292789 C11orf87 -0.43 -7.74 -0.39 1.17e-13 Schizophrenia; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg06873352 chr17:61820015 STRADA 0.72 13.04 0.58 1.11e-31 Prudent dietary pattern; LUSC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg17279839 chr7:150038598 RARRES2 0.45 6.92 0.35 2.28e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.73 0.35 7.58e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg13531842 chr10:38383804 ZNF37A -0.45 -7.08 -0.36 8.53e-12 Extrinsic epigenetic age acceleration; LUSC cis rs911119 0.955 rs8116859 chr20:23590703 A/T cg16589663 chr20:23618590 CST3 0.57 6.79 0.35 5.12e-11 Chronic kidney disease; LUSC cis rs9326248 0.539 rs518181 chr11:116772787 C/A cg26566898 chr11:117069891 TAGLN 0.38 7.22 0.37 3.44e-12 Blood protein levels; LUSC cis rs2455601 0.608 rs10840137 chr11:8890079 G/A cg12365402 chr11:9010492 NRIP3 -0.37 -5.95 -0.31 6.74e-9 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24278218 chr17:62207299 ERN1 -0.5 -6.06 -0.31 3.71e-9 Bipolar disorder and schizophrenia; LUSC trans rs1015291 0.708 rs2731614 chr12:19999688 T/C cg01501474 chr7:55323552 NA -0.46 -6.18 -0.32 1.85e-9 Diastolic blood pressure; LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs9323205 0.953 rs11623710 chr14:51694261 C/T cg23942311 chr14:51606299 NA -0.47 -9.75 -0.47 6.34e-20 Cancer; LUSC cis rs7267979 1.000 rs2424704 chr20:25273929 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.87 19.81 0.73 2.69e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1372520 0.684 rs2737010 chr4:90746466 G/A cg15133208 chr4:90757351 SNCA -0.54 -8.34 -0.42 1.92e-15 Neuroticism; LUSC trans rs7615952 0.599 rs7652883 chr3:125707977 T/G cg07211511 chr3:129823064 LOC729375 -0.8 -10.65 -0.5 5.31e-23 Blood pressure (smoking interaction); LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs7119 0.745 rs12911649 chr15:77807127 C/T cg27398640 chr15:77910606 LINGO1 -0.29 -6.12 -0.32 2.58e-9 Type 2 diabetes; LUSC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg00310523 chr12:86230176 RASSF9 0.52 9.81 0.47 3.84e-20 Major depressive disorder; LUSC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg06046430 chr4:77819534 ANKRD56 0.45 6.29 0.33 1e-9 Emphysema distribution in smoking; LUSC cis rs11568819 1.000 rs11568819 chr11:102401633 C/T cg01813071 chr11:102401616 MMP7 1.07 9.44 0.46 6.39e-19 Blood protein levels; LUSC cis rs67460515 0.563 rs9876142 chr3:160780968 A/G cg03342759 chr3:160939853 NMD3 0.42 5.94 0.31 7.16e-9 Parkinson's disease; LUSC cis rs17253792 0.822 rs17685102 chr14:56129214 A/G cg01858014 chr14:56050164 KTN1 -0.79 -6.68 -0.34 9.73e-11 Putamen volume; LUSC cis rs2580764 0.565 rs6760429 chr2:55228499 C/T cg20993754 chr2:55226987 RTN4 0.35 5.86 0.31 1.12e-8 Mean platelet volume; LUSC trans rs9929218 0.954 rs7199991 chr16:68818245 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -11.19 -0.52 6.92e-25 Colorectal cancer; LUSC cis rs9311676 0.656 rs55668308 chr3:58388453 C/T cg26110898 chr3:58419937 PDHB 0.4 6.49 0.33 3.05e-10 Systemic lupus erythematosus; LUSC cis rs7539542 0.556 rs2275734 chr1:202887295 C/T cg19681188 chr1:202830198 LOC148709 0.43 6.31 0.33 8.73e-10 Mean platelet volume; LUSC cis rs7617773 0.780 rs13090538 chr3:48370769 A/C cg20734569 chr3:48348370 SPINK8 -0.47 -8.05 -0.4 1.42e-14 Coronary artery disease; LUSC cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg23711669 chr6:146136114 FBXO30 0.89 16.36 0.67 1.39e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg16339924 chr4:17578868 LAP3 0.49 7.53 0.38 4.83e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4891159 0.790 rs7234653 chr18:74111988 C/T cg24786174 chr18:74118243 ZNF516 -0.83 -15.33 -0.64 1.49e-40 Longevity; LUSC cis rs4332037 0.901 rs11767040 chr7:1945468 C/T cg23422044 chr7:1970798 MAD1L1 -0.65 -7.36 -0.37 1.46e-12 Bipolar disorder; LUSC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs8072100 0.934 rs9905583 chr17:45741016 C/T cg25173405 chr17:45401733 C17orf57 -0.39 -6.13 -0.32 2.46e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4242434 0.819 rs6999893 chr8:22465427 T/C cg03733263 chr8:22462867 KIAA1967 0.84 14.19 0.61 4.2500000000000003e-36 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg26408565 chr15:76604113 ETFA -0.49 -7.92 -0.4 3.55e-14 Blood metabolite levels; LUSC cis rs9733 0.621 rs932054 chr1:150539867 C/G cg09365446 chr1:150670422 GOLPH3L -0.42 -6.12 -0.32 2.6e-9 Tonsillectomy; LUSC cis rs1865721 1.000 rs7236756 chr18:73175689 T/C cg26385618 chr18:73139727 C18orf62 -0.49 -8.38 -0.42 1.5e-15 Intelligence; LUSC cis rs34779708 0.931 rs11010132 chr10:35517265 C/G cg04310649 chr10:35416472 CREM -0.39 -6.05 -0.31 3.84e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs61931739 0.500 rs11053213 chr12:34466395 G/T cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.3e-10 Morning vs. evening chronotype; LUSC cis rs679087 0.606 rs302347 chr12:29944246 G/A cg14258853 chr12:29935411 TMTC1 -0.68 -8.18 -0.41 5.89e-15 Schizophrenia; LUSC cis rs9393777 0.545 rs56303243 chr6:26485727 G/A cg12292205 chr6:26970375 C6orf41 -0.63 -7.6 -0.38 3.04e-13 Intelligence (multi-trait analysis); LUSC cis rs6700896 0.864 rs7515766 chr1:66167452 G/A cg04111102 chr1:66153794 NA -0.32 -6.95 -0.36 1.98e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg06484146 chr7:12443880 VWDE -0.63 -7.41 -0.38 1.07e-12 Coronary artery disease; LUSC cis rs500891 0.525 rs1170347 chr6:84021294 G/A cg08257003 chr6:84140564 ME1 0.33 7.11 0.36 6.96e-12 Platelet-derived growth factor BB levels; LUSC cis rs7927592 0.913 rs10896329 chr11:68250029 A/G cg20283391 chr11:68216788 NA -0.61 -8.51 -0.42 5.97e-16 Total body bone mineral density; LUSC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg13531842 chr10:38383804 ZNF37A -0.46 -7.23 -0.37 3.4e-12 Extrinsic epigenetic age acceleration; LUSC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.8 -0.39 8.02e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1448094 0.845 rs10863123 chr12:86346254 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -6.66 -0.34 1.1e-10 Major depressive disorder; LUSC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg24209194 chr3:40518798 ZNF619 -0.47 -6.23 -0.32 1.37e-9 Renal cell carcinoma; LUSC cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg01884057 chr2:25150051 NA 0.47 11.28 0.53 3.15e-25 Body mass index in non-asthmatics; LUSC cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg05294307 chr14:35346193 BAZ1A -0.52 -6.93 -0.35 2.16e-11 Psoriasis; LUSC cis rs2832077 0.943 rs11701777 chr21:30155828 T/C cg08807101 chr21:30365312 RNF160 -0.51 -6.52 -0.34 2.63e-10 Cognitive test performance; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12046629 chr8:59466299 SDCBP 0.44 6.33 0.33 7.95e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9326248 0.581 rs7120515 chr11:116991926 A/G cg11861562 chr11:117069780 TAGLN 0.36 7.15 0.36 5.49e-12 Blood protein levels; LUSC cis rs7827545 1.000 rs7823948 chr8:135566580 G/A cg17885191 chr8:135476712 NA 0.57 8.5 0.42 6.26e-16 Hypertension (SNP x SNP interaction); LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg03790207 chr6:42947109 PEX6 -0.47 -6.95 -0.36 1.91e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg21770322 chr7:97807741 LMTK2 -0.44 -7.35 -0.37 1.55e-12 Breast cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02662155 chr11:46639265 KIAA0652;HARBI1 0.43 6.51 0.34 2.78e-10 Triglycerides; LUSC cis rs4927850 0.666 rs4927853 chr3:195752053 G/C cg12923728 chr3:195709715 SDHAP1 -0.78 -11.86 -0.54 2.49e-27 Pancreatic cancer; LUSC cis rs4622329 0.615 rs7136688 chr12:102294494 T/A cg23541617 chr12:102225335 GNPTAB 0.25 5.97 0.31 6.17e-9 Systemic lupus erythematosus; LUSC cis rs9467773 0.620 rs9461276 chr6:26595168 T/C cg09904177 chr6:26538194 HMGN4 0.68 12.18 0.55 1.72e-28 Intelligence (multi-trait analysis); LUSC cis rs61869271 0.805 rs7086663 chr10:116766336 A/T cg23260525 chr10:116636907 FAM160B1 0.3 6.13 0.32 2.52e-9 Tonsillectomy; LUSC trans rs8073060 0.855 rs12150450 chr17:33868896 A/T cg19694781 chr19:47549865 TMEM160 0.7 10.43 0.5 3.08e-22 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs61931739 0.517 rs1843737 chr12:34015305 A/G cg26384229 chr12:38710491 ALG10B 0.66 10.8 0.51 1.67e-23 Morning vs. evening chronotype; LUSC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11890956 chr21:40555474 PSMG1 0.91 16.4 0.67 9.5e-45 Cognitive function; LUSC cis rs7192380 0.964 rs8055756 chr16:69648653 A/G cg26679644 chr16:69762563 NA -0.35 -6.25 -0.32 1.26e-9 Sjögren's syndrome; LUSC trans rs4332037 0.539 rs56180486 chr7:2050747 C/T cg25206134 chr2:45395956 NA 0.62 7.22 0.37 3.47e-12 Bipolar disorder; LUSC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg02423579 chr7:2872169 GNA12 -0.39 -5.83 -0.3 1.3e-8 Height; LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg00166722 chr3:10149974 C3orf24 0.56 7.57 0.38 3.75e-13 Alzheimer's disease; LUSC cis rs8058578 0.832 rs3812999 chr16:30773605 G/T cg05768032 chr16:30646687 NA 0.39 5.86 0.31 1.1e-8 Multiple myeloma; LUSC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg25204440 chr1:209979598 IRF6 -0.5 -5.76 -0.3 1.95e-8 Cleft lip with or without cleft palate; LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg05025164 chr4:1340916 KIAA1530 0.42 6.43 0.33 4.38e-10 Obesity-related traits; LUSC cis rs7119 0.717 rs8040702 chr15:77803615 G/A cg27398640 chr15:77910606 LINGO1 -0.28 -6.02 -0.31 4.56e-9 Type 2 diabetes; LUSC cis rs1348850 0.750 rs55792594 chr2:178496468 C/T cg22681709 chr2:178499509 PDE11A -0.56 -10.66 -0.5 4.9e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs6487679 1.000 rs1017302 chr12:9367402 A/G cg00504896 chr12:9437009 LOC642846 -0.44 -5.77 -0.3 1.85e-8 Non-alcoholic fatty liver disease histology (AST); LUSC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg07741184 chr6:167504864 NA -0.35 -6.39 -0.33 5.46e-10 Crohn's disease; LUSC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.61e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg25427524 chr10:38739819 LOC399744 -0.71 -13.26 -0.59 1.53e-32 Extrinsic epigenetic age acceleration; LUSC cis rs4711350 0.765 rs756138 chr6:33755711 G/C cg18005901 chr6:33739558 LEMD2 -0.39 -5.74 -0.3 2.07e-8 Schizophrenia; LUSC trans rs66887589 0.934 rs7681980 chr4:120533223 G/A cg25214090 chr10:38739885 LOC399744 -0.37 -6.06 -0.31 3.74e-9 Diastolic blood pressure; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg09436375 chr6:42928200 GNMT -0.3 -6.82 -0.35 4.31e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9287719 0.967 rs6709466 chr2:10748257 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.71e-9 Body mass index; LUSC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg00129232 chr17:37814104 STARD3 -0.44 -6.32 -0.33 8.34e-10 Asthma; LUSC cis rs7119 0.689 rs12916833 chr15:77819778 G/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.59 -0.34 1.73e-10 Type 2 diabetes; LUSC cis rs62432291 0.764 rs433256 chr6:159660105 C/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg07677032 chr17:61819896 STRADA 0.53 8.93 0.44 2.87e-17 Prudent dietary pattern; LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9937943 0.667 rs12934000 chr16:74623420 T/G cg01733217 chr16:74700730 RFWD3 0.61 6.47 0.33 3.59e-10 Neutrophil percentage of white cells; LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg08742575 chr21:47604166 C21orf56 0.48 7.38 0.37 1.3e-12 Testicular germ cell tumor; LUSC cis rs7640424 0.819 rs34154497 chr3:107824222 T/C cg09227934 chr3:107805635 CD47 -0.44 -6.94 -0.36 2.01e-11 Body mass index; LUSC cis rs9902453 1.000 rs62070270 chr17:28263980 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.85 0.44 5.15e-17 Coffee consumption (cups per day); LUSC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.44 -6.37 -0.33 6.31e-10 Schizophrenia; LUSC trans rs11039798 0.764 rs11039771 chr11:48513273 C/T cg03929089 chr4:120376271 NA 0.65 6.07 0.32 3.39e-9 Axial length; LUSC trans rs4332037 0.950 rs56403963 chr7:1946130 C/G cg11693508 chr17:37793320 STARD3 0.65 7.95 0.4 2.93e-14 Bipolar disorder; LUSC cis rs9467711 0.559 rs6920256 chr6:26537801 G/A cg09904177 chr6:26538194 HMGN4 -0.71 -6.38 -0.33 5.84e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg26408565 chr15:76604113 ETFA -0.48 -7.63 -0.39 2.46e-13 Blood metabolite levels; LUSC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg03060546 chr3:49711283 APEH 0.72 12.18 0.55 1.79e-28 Resting heart rate; LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC trans rs35110281 0.693 rs3819161 chr21:45092653 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.39 0.49 4.17e-22 Mean corpuscular volume; LUSC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg06600287 chr1:53387719 ECHDC2 -0.3 -6.26 -0.32 1.19e-9 Monocyte count; LUSC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg25204440 chr1:209979598 IRF6 0.5 5.72 0.3 2.4e-8 Cleft lip with or without cleft palate; LUSC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg02782426 chr3:40428986 ENTPD3 0.33 6.28 0.32 1.05e-9 Renal cell carcinoma; LUSC cis rs722599 0.748 rs2300599 chr14:75359441 A/G cg08847533 chr14:75593920 NEK9 -0.47 -6.74 -0.35 7.04e-11 IgG glycosylation; LUSC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg18512352 chr11:47633146 NA -0.43 -9.06 -0.44 1.12e-17 Subjective well-being; LUSC cis rs7246657 0.653 rs10425441 chr19:37670648 T/C cg23950597 chr19:37808831 NA -0.58 -5.88 -0.31 1.01e-8 Coronary artery calcification; LUSC cis rs5758511 0.773 rs62240999 chr22:42355563 C/G cg12850546 chr22:42539477 CYP2D7P1 -0.49 -6.05 -0.31 3.84e-9 Birth weight; LUSC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg12311346 chr5:56204834 C5orf35 0.84 13.52 0.59 1.56e-33 Initial pursuit acceleration; LUSC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg01017244 chr2:74357527 NA 0.72 13.61 0.6 7.46e-34 Gestational age at birth (maternal effect); LUSC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg13319975 chr6:146136371 FBXO30 0.52 7.82 0.39 7.03e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7178572 0.539 rs16968809 chr15:77672118 C/T cg22256960 chr15:77711686 NA 0.52 7.54 0.38 4.49e-13 Type 2 diabetes; LUSC cis rs9314323 0.964 rs3808579 chr8:26250682 C/T cg13160058 chr8:26243215 BNIP3L -0.41 -7.43 -0.38 9.2e-13 Red cell distribution width; LUSC cis rs76419734 0.510 rs2216515 chr4:106750214 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.52 -5.94 -0.31 7.22e-9 Post bronchodilator FEV1; LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC cis rs796364 0.806 rs11679676 chr2:201040981 C/T cg23649088 chr2:200775458 C2orf69 -0.56 -6.45 -0.33 3.82e-10 Schizophrenia; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03576123 chr11:487126 PTDSS2 -1.05 -11.18 -0.52 7.13e-25 Body mass index; LUSC cis rs2019216 0.500 rs7502283 chr17:21878561 G/C cg22648282 chr17:21454238 C17orf51 -0.54 -7.82 -0.39 6.97e-14 Pelvic organ prolapse; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14787155 chr3:108308533 DZIP3;KIAA1524 -0.36 -6.11 -0.32 2.72e-9 Electrocardiographic conduction measures; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg16325326 chr1:53192061 ZYG11B 0.83 14.59 0.62 1.17e-37 Monocyte count; LUSC cis rs9443645 0.527 rs4706743 chr6:79615793 G/T cg23262351 chr6:79576851 IRAK1BP1 -0.39 -5.94 -0.31 7.16e-9 Intelligence (multi-trait analysis); LUSC cis rs977987 0.902 rs4888430 chr16:75494424 T/C cg03315344 chr16:75512273 CHST6 0.58 11.34 0.53 1.95e-25 Dupuytren's disease; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10667969 chr3:149181941 NA -0.4 -6.39 -0.33 5.54e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1577917 0.874 rs11756621 chr6:86740063 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.84 -0.35 3.73e-11 Response to antipsychotic treatment; LUSC cis rs4466137 1.000 rs1154888 chr5:82977410 C/A cg15083037 chr5:83017644 HAPLN1 -0.59 -7.78 -0.39 9.16e-14 Prostate cancer; LUSC cis rs10761482 1.000 rs10761482 chr10:62085337 C/T cg18175470 chr10:62150864 ANK3 0.44 6.23 0.32 1.39e-9 Schizophrenia; LUSC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg21573476 chr21:45109991 RRP1B -0.4 -6.37 -0.33 6.25e-10 Mean corpuscular volume; LUSC cis rs7568458 0.870 rs1010 chr2:85808982 C/T cg23752985 chr2:85803571 VAMP8 -0.35 -7.63 -0.39 2.56e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2282300 0.739 rs10835647 chr11:30313268 A/G cg25418670 chr11:30344373 C11orf46 -0.63 -9.11 -0.45 8.01e-18 Morning vs. evening chronotype; LUSC cis rs4285028 0.948 rs73855480 chr3:121676646 A/G cg11130432 chr3:121712080 ILDR1 -0.63 -9.57 -0.46 2.41e-19 Multiple sclerosis; LUSC cis rs2730245 0.592 rs2657385 chr7:158649373 A/G cg11984989 chr7:158649758 WDR60 1.08 22.43 0.78 1.26e-68 Height; LUSC cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg17845761 chr1:175162550 KIAA0040 -0.31 -5.95 -0.31 6.59e-9 Alcohol dependence; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg11060661 chr22:24314208 DDT;DDTL 0.43 7.0 0.36 1.39e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.7 11.79 0.54 4.52e-27 Menarche (age at onset); LUSC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg02018176 chr4:1364513 KIAA1530 0.54 9.68 0.47 1.03e-19 Longevity; LUSC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg14403583 chr14:105418241 AHNAK2 -0.58 -9.66 -0.47 1.29e-19 Rheumatoid arthritis; LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg11766577 chr21:47581405 C21orf56 -0.52 -7.94 -0.4 3.05e-14 Testicular germ cell tumor; LUSC cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg07828340 chr4:882639 GAK 1.07 10.8 0.51 1.67e-23 Intelligence (multi-trait analysis); LUSC cis rs6005807 0.719 rs9625512 chr22:29020756 G/C cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg17971929 chr21:40555470 PSMG1 0.79 13.76 0.6 2.01e-34 Cognitive function; LUSC cis rs17407555 0.520 rs4292327 chr4:9943700 G/A cg11266682 chr4:10021025 SLC2A9 -0.44 -6.12 -0.32 2.68e-9 Schizophrenia (age at onset); LUSC cis rs62027291 0.950 rs17465482 chr15:77262489 A/G cg26408565 chr15:76604113 ETFA 0.56 6.45 0.33 4.01e-10 Plateletcrit; LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg00701064 chr4:6280414 WFS1 0.59 14.34 0.62 1.11e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1153858 0.945 rs16943246 chr15:45720597 G/A cg21132104 chr15:45694354 SPATA5L1 0.55 7.26 0.37 2.73e-12 Homoarginine levels; LUSC cis rs16854884 0.657 rs7610378 chr3:143711298 G/A cg06585982 chr3:143692056 C3orf58 0.48 7.33 0.37 1.76e-12 Economic and political preferences (feminism/equality); LUSC cis rs453301 0.506 rs476845 chr8:8622877 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -7.81 -0.39 7.27e-14 Joint mobility (Beighton score); LUSC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg13206674 chr6:150067644 NUP43 0.6 9.36 0.46 1.17e-18 Lung cancer; LUSC cis rs9905704 0.718 rs758377 chr17:56607124 T/C cg19466818 chr17:56409534 MIR142 0.35 6.47 0.33 3.4e-10 Testicular germ cell tumor; LUSC cis rs4594175 0.926 rs66625118 chr14:51631062 T/C cg23942311 chr14:51606299 NA 0.3 5.68 0.3 2.86e-8 Cancer; LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.67 0.34 1.07e-10 Menopause (age at onset); LUSC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs317689 0.690 rs595348 chr12:69638610 T/C cg20891283 chr12:69753455 YEATS4 0.44 5.82 0.3 1.36e-8 Response to diuretic therapy; LUSC cis rs7809950 1.000 rs7782057 chr7:107098877 T/A cg23024343 chr7:107201750 COG5 -0.55 -8.75 -0.43 1.06e-16 Coronary artery disease; LUSC cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg06552810 chr11:31128660 NA -0.42 -7.4 -0.38 1.09e-12 Red blood cell count; LUSC trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg06636001 chr8:8085503 FLJ10661 -0.62 -9.2 -0.45 3.87e-18 Neuroticism; LUSC cis rs10140922 0.966 rs8003074 chr14:35821692 A/C cg07166546 chr14:35805898 NA -0.24 -5.95 -0.31 6.7e-9 Hip circumference adjusted for BMI; LUSC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg18357645 chr12:58087776 OS9 -0.5 -6.54 -0.34 2.32e-10 Multiple sclerosis; LUSC cis rs17604090 1.000 rs17603986 chr7:29690489 C/T cg19413766 chr7:29689036 LOC646762 -0.63 -7.48 -0.38 6.73e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC trans rs1997103 1.000 rs6950311 chr7:55400990 G/A cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10489202 0.686 rs11585936 chr1:167847069 G/T cg24449463 chr1:168025552 DCAF6 -0.56 -6.4 -0.33 5.38e-10 Schizophrenia; LUSC cis rs10489202 0.913 rs380753 chr1:168035273 G/T cg24449463 chr1:168025552 DCAF6 -0.66 -9.13 -0.45 6.8e-18 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00944502 chr5:64858997 PPWD1;CENPK 0.46 6.2 0.32 1.68e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg05985134 chr18:33552581 C18orf21 0.51 6.73 0.35 7.4e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs9650315 0.810 rs35845576 chr8:57202652 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.31 0.37 1.93e-12 Height; LUSC cis rs1048238 0.506 rs10737911 chr1:16167855 C/T cg21385522 chr1:16154831 NA -0.57 -9.15 -0.45 5.61e-18 Systolic blood pressure; LUSC cis rs7615316 0.528 rs13074172 chr3:142352978 A/G cg16271453 chr3:142027066 XRN1 -0.45 -7.92 -0.4 3.56e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7605827 0.930 rs10929373 chr2:15663317 T/C cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.62e-16 Educational attainment (years of education); LUSC cis rs7909074 1.000 rs4948925 chr10:45392455 C/T cg04218760 chr10:45406644 TMEM72 -0.28 -6.94 -0.35 2.08e-11 Mean corpuscular volume; LUSC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg18404041 chr3:52824283 ITIH1 0.44 7.72 0.39 1.37e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1371867 0.846 rs1660323 chr8:101278724 T/A cg00191853 chr8:101177733 SPAG1 -0.37 -5.95 -0.31 6.76e-9 Atrioventricular conduction; LUSC cis rs10751667 1.000 rs7395691 chr11:985006 T/C ch.11.42038R chr11:967971 AP2A2 0.54 8.06 0.4 1.41e-14 Alzheimer's disease (late onset); LUSC cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg27446573 chr6:127587934 RNF146 -0.92 -15.23 -0.64 3.94e-40 Breast cancer; LUSC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg02034447 chr16:89574710 SPG7 0.43 6.4 0.33 5.18e-10 Multiple myeloma (IgH translocation); LUSC cis rs13082711 0.911 rs13075550 chr3:27427618 A/G cg02860705 chr3:27208620 NA 0.5 8.64 0.43 2.34e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs1005277 0.505 rs7917943 chr10:38195811 T/A cg17830980 chr10:43048298 ZNF37B 0.43 6.71 0.34 8.21e-11 Extrinsic epigenetic age acceleration; LUSC cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg16339924 chr4:17578868 LAP3 0.47 7.0 0.36 1.38e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7107174 0.892 rs10899490 chr11:78105879 C/T cg02023728 chr11:77925099 USP35 0.47 7.11 0.36 7.26e-12 Testicular germ cell tumor; LUSC cis rs983392 0.679 rs1026255 chr11:60029949 A/G cg24026212 chr11:59952134 MS4A6A -0.37 -6.39 -0.33 5.58e-10 Alzheimer's disease (late onset); LUSC cis rs2688608 0.592 rs10824032 chr10:75528130 G/A cg17411546 chr10:75410026 SYNPO2L -0.53 -8.07 -0.4 1.26e-14 Inflammatory bowel disease; LUSC cis rs477895 1.000 rs66968227 chr11:64070930 T/C cg23719950 chr11:63933701 MACROD1 -0.62 -7.41 -0.38 1.05e-12 Mean platelet volume; LUSC cis rs2346177 0.806 rs56048837 chr2:46656647 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.51 -7.96 -0.4 2.76e-14 HDL cholesterol; LUSC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs72781680 1.000 rs72798418 chr2:24188922 A/G cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs6565180 0.791 rs4247355 chr16:30392099 A/G cg17640201 chr16:30407289 ZNF48 0.9 15.41 0.64 7.41e-41 Tonsillectomy; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.57 -8.86 -0.44 5e-17 Lymphocyte counts; LUSC cis rs28830936 1.000 rs12441300 chr15:42102845 A/G cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.98 -0.31 5.63e-9 Diastolic blood pressure; LUSC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg27165867 chr14:105738592 BRF1 -0.53 -7.8 -0.39 8.2e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg21535247 chr6:8435926 SLC35B3 0.58 9.02 0.44 1.46e-17 Motion sickness; LUSC cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg03146154 chr1:46216737 IPP 0.52 7.58 0.38 3.4e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs62458065 1.000 rs10246687 chr7:32465183 T/A cg20159608 chr7:32802032 NA -0.57 -7.01 -0.36 1.34e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs16976116 0.901 rs28489312 chr15:55494048 A/C cg11288833 chr15:55489084 RSL24D1 0.5 6.0 0.31 5.19e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg11764359 chr7:65958608 NA 0.7 10.85 0.51 1.04e-23 Aortic root size; LUSC trans rs9951602 0.512 rs7240758 chr18:76650677 T/C cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC cis rs7267979 1.000 rs2184000 chr20:25395878 G/A cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg16680214 chr1:154839983 KCNN3 -0.58 -11.49 -0.53 5.62e-26 Prostate cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27098574 chr16:75285489 BCAR1 -0.48 -6.65 -0.34 1.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs72781680 0.821 rs2339887 chr2:24198376 G/A cg08917208 chr2:24149416 ATAD2B 0.6 6.9 0.35 2.66e-11 Lymphocyte counts; LUSC cis rs131777 0.575 rs963980 chr22:51022117 C/A cg00083937 chr22:51039805 MAPK8IP2 0.51 8.63 0.43 2.53e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10982590 chr2:27579041 GTF3C2 -0.44 -5.98 -0.31 5.67e-9 Hepatitis; LUSC trans rs7726558 0.731 rs80063787 chr5:118831460 G/A cg14402224 chr7:50570049 DDC -0.48 -6.12 -0.32 2.55e-9 QT interval (sulfonylurea treatment interaction); LUSC cis rs28829049 0.508 rs4578242 chr1:19391565 G/C cg13387374 chr1:19411106 UBR4 0.43 5.88 0.31 9.72e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC trans rs1994135 0.647 rs11052745 chr12:33695999 G/T cg26384229 chr12:38710491 ALG10B 0.61 8.52 0.42 5.63e-16 Resting heart rate; LUSC cis rs1018836 0.828 rs9297871 chr8:91572731 G/A cg16814680 chr8:91681699 NA -0.69 -11.11 -0.52 1.28e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs3764563 1.000 rs4239617 chr19:15741537 C/T cg20725493 chr19:15740067 CYP4F8 -0.64 -6.62 -0.34 1.44e-10 Inflammatory biomarkers; LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 6.56 0.34 2.07e-10 Bipolar disorder; LUSC cis rs4319547 0.695 rs10773103 chr12:122856532 A/G cg23029597 chr12:123009494 RSRC2 0.75 9.5 0.46 4.15e-19 Body mass index; LUSC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg00316803 chr15:76480434 C15orf27 -0.41 -6.99 -0.36 1.5e-11 Blood metabolite levels; LUSC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg13393036 chr8:95962371 TP53INP1 0.38 7.91 0.4 3.75e-14 Type 2 diabetes; LUSC cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.84 -0.35 3.81e-11 Monocyte percentage of white cells; LUSC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.23 -0.37 3.37e-12 Blood metabolite levels; LUSC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg18904891 chr8:8559673 CLDN23 -0.41 -6.35 -0.33 6.96e-10 Mood instability; LUSC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg12560992 chr17:57184187 TRIM37 0.83 15.25 0.64 3.12e-40 Intelligence (multi-trait analysis); LUSC cis rs10464366 1.000 rs10951593 chr7:39121390 C/T cg18850127 chr7:39170497 POU6F2 0.49 7.06 0.36 9.94e-12 IgG glycosylation; LUSC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg10645314 chr2:3704589 ALLC -0.47 -7.18 -0.37 4.47e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg21775979 chr11:780331 NA 0.46 7.77 0.39 9.6e-14 Breast cancer; LUSC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg12311346 chr5:56204834 C5orf35 -0.8 -9.17 -0.45 4.89e-18 Type 2 diabetes; LUSC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg10523679 chr1:76189770 ACADM 0.9 15.7 0.65 5.45e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg26769984 chr7:1090371 C7orf50 0.58 8.97 0.44 2.17e-17 Bronchopulmonary dysplasia; LUSC cis rs12900413 0.687 rs12903462 chr15:90304075 C/T cg24249390 chr15:90295951 MESP1 -0.36 -5.69 -0.3 2.82e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9287719 0.967 rs12995602 chr2:10753542 C/A cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs11583043 0.874 rs41312668 chr1:101443582 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.43 5.89 0.31 9.41e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs1371867 0.846 rs1788205 chr8:101306546 G/C cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.35e-15 Atrioventricular conduction; LUSC cis rs7799006 0.657 rs10447540 chr7:2301484 A/G cg12823233 chr7:2316876 SNX8 -0.46 -7.8 -0.39 7.86e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs5758265 1 rs5758265 chr22:41617897 G/A cg13813247 chr22:41461852 NA -0.36 -6.55 -0.34 2.17e-10 Depressive symptoms (multi-trait analysis); LUSC cis rs7172677 0.961 rs12102035 chr15:75418871 A/G cg14664628 chr15:75095509 CSK -0.44 -5.77 -0.3 1.85e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2976388 1.000 rs2976394 chr8:143763622 C/T cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC trans rs7647973 0.626 rs9829155 chr3:49817450 T/C cg21659725 chr3:3221576 CRBN 0.68 8.24 0.41 3.83e-15 Menarche (age at onset); LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6456156 0.586 rs2017338 chr6:167471714 G/A cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs4268898 0.760 rs7597919 chr2:24563646 A/G cg06627628 chr2:24431161 ITSN2 0.58 8.35 0.42 1.8e-15 Asthma; LUSC cis rs12594515 1.000 rs7162201 chr15:45992658 A/C cg06207120 chr15:45996521 NA 0.38 5.86 0.31 1.14e-8 Waist circumference;Weight; LUSC cis rs7666738 0.546 rs34621463 chr4:98793357 G/C cg05340658 chr4:99064831 C4orf37 0.58 8.63 0.43 2.47e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs4474465 0.850 rs10793329 chr11:78265655 G/C cg27205649 chr11:78285834 NARS2 0.51 6.05 0.31 3.99e-9 Alzheimer's disease (survival time); LUSC cis rs17401966 0.518 rs10864453 chr1:10407169 T/G cg17425144 chr1:10567563 PEX14 -0.35 -6.25 -0.32 1.27e-9 Hepatocellular carcinoma; LUSC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg07777115 chr5:623756 CEP72 -0.47 -5.77 -0.3 1.78e-8 Lung disease severity in cystic fibrosis; LUSC cis rs79911532 0.515 rs10226745 chr7:75843603 C/T cg03592824 chr7:75666768 STYXL1 0.67 6.64 0.34 1.25e-10 Mononucleosis; LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs7172677 0.732 rs55922358 chr15:75313967 G/C cg09165964 chr15:75287851 SCAMP5 0.46 5.74 0.3 2.16e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2737618 0.630 rs2821328 chr1:200082051 G/A cg21825944 chr1:200113062 NR5A2 -0.3 -5.72 -0.3 2.41e-8 Uric acid levels; LUSC cis rs6690583 0.524 rs12030837 chr1:85519383 A/G cg11262906 chr1:85462892 MCOLN2 -0.64 -6.09 -0.32 3.13e-9 Serum sulfate level; LUSC cis rs7818345 0.967 rs4412390 chr8:19270143 A/T cg11303988 chr8:19266685 CSGALNACT1 -0.37 -7.12 -0.36 6.74e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1448094 0.872 rs4919777 chr12:86358491 C/T cg00310523 chr12:86230176 RASSF9 0.37 6.54 0.34 2.26e-10 Major depressive disorder; LUSC cis rs55883249 0.957 rs17453675 chr2:9754407 A/G cg23886495 chr2:9695866 ADAM17 0.48 5.75 0.3 2.07e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg22823121 chr1:150693482 HORMAD1 0.57 8.85 0.44 5.08e-17 Tonsillectomy; LUSC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg15001381 chr16:403314 AXIN1 0.34 6.37 0.33 6.28e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs2857891 0.695 rs2346002 chr11:6987741 T/C cg04053776 chr11:6947353 ZNF215 0.42 6.18 0.32 1.86e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.98 0.44 1.99e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs12220238 1.000 rs11000936 chr10:75992383 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.18e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg24692254 chr21:30365293 RNF160 -0.79 -14.4 -0.62 6.32e-37 Dental caries; LUSC cis rs3925075 1.000 rs11859274 chr16:31361059 C/T cg02846316 chr16:31340340 ITGAM 0.36 6.73 0.35 7.2e-11 IgA nephropathy; LUSC cis rs17818399 0.926 rs35350086 chr2:46834036 C/G cg02822958 chr2:46747628 ATP6V1E2 0.39 5.75 0.3 2.01e-8 Height; LUSC trans rs867371 0.762 rs1846910 chr15:82571780 G/A cg18393722 chr15:85113863 UBE2QP1 -0.49 -7.17 -0.37 4.76e-12 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC trans rs2975734 0.680 rs1052453 chr8:10108325 C/T cg15556689 chr8:8085844 FLJ10661 -0.48 -6.38 -0.33 5.8e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs13401104 0.754 rs11902623 chr2:237117624 G/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC trans rs11764590 0.671 rs56226325 chr7:2078981 C/T cg10840412 chr1:235813424 GNG4 0.53 6.33 0.33 8.1e-10 Neuroticism; LUSC cis rs1178127 0.580 rs1178178 chr7:18799718 G/A cg02370815 chr7:18831390 HDAC9 -0.39 -5.86 -0.31 1.13e-8 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); LUSC cis rs559928 0.557 rs7122408 chr11:63898826 G/T cg05555928 chr11:63887634 MACROD1 -0.49 -6.18 -0.32 1.87e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7674212 0.541 rs2720458 chr4:104052963 C/G cg16532752 chr4:104119610 CENPE -0.46 -6.33 -0.33 7.87e-10 Type 2 diabetes; LUSC cis rs6700896 0.931 rs17127849 chr1:66105512 A/G cg04111102 chr1:66153794 NA 0.32 7.06 0.36 9.67e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg11764359 chr7:65958608 NA -0.62 -9.33 -0.45 1.47e-18 Calcium levels; LUSC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg18765753 chr7:1198926 ZFAND2A -0.37 -6.58 -0.34 1.77e-10 Longevity;Endometriosis; LUSC cis rs12579753 1.000 rs12367791 chr12:82237278 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10489525 1.000 rs10489525 chr1:115263685 A/G cg01522456 chr1:115632236 TSPAN2 -0.43 -6.06 -0.31 3.72e-9 Autism; LUSC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg13206674 chr6:150067644 NUP43 0.56 8.69 0.43 1.67e-16 Lung cancer; LUSC cis rs10743315 0.557 rs10505840 chr12:19403729 G/T cg02471346 chr12:19282374 PLEKHA5 0.82 6.42 0.33 4.72e-10 Gut microbiota (bacterial taxa); LUSC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12655452 chr1:77685094 PIGK -0.44 -6.03 -0.31 4.34e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.69e-9 Aortic root size; LUSC cis rs4363385 0.747 rs1933383 chr1:152963468 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.6 -0.38 2.97e-13 Inflammatory skin disease; LUSC trans rs1997103 1.000 rs2877284 chr7:55408778 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg11663144 chr21:46675770 NA -0.41 -7.14 -0.36 6.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3771570 1.000 rs60604866 chr2:242352257 A/G cg21155796 chr2:242212141 HDLBP 0.61 6.76 0.35 6.18e-11 Prostate cancer; LUSC trans rs11700980 1.000 rs2832049 chr21:30129277 T/C cg05609335 chr17:75789393 NA 0.4 6.19 0.32 1.76e-9 QRS complex (12-leadsum); LUSC cis rs9650657 0.675 rs2409658 chr8:10668965 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.31 -0.33 8.62e-10 Neuroticism; LUSC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs2235649 0.552 rs8056773 chr16:1959432 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.49 -6.16 -0.32 2.09e-9 Blood metabolite levels; LUSC cis rs2970818 0.731 rs61909580 chr12:4595291 C/T cg11146114 chr12:4671731 NA -0.6 -5.71 -0.3 2.54e-8 Phosphorus levels; LUSC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.18 0.52 7.04e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs782590 0.721 rs782641 chr2:55929294 C/T cg18811423 chr2:55921094 PNPT1 0.85 14.56 0.62 1.58e-37 Metabolic syndrome; LUSC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.89 -0.44 3.94e-17 Personality dimensions; LUSC cis rs6496044 0.568 rs2880764 chr15:86056408 A/G cg13263323 chr15:86062960 AKAP13 -0.36 -5.95 -0.31 6.73e-9 Interstitial lung disease; LUSC cis rs1185460 0.565 rs10892325 chr11:118912702 T/C cg01677386 chr11:118938358 VPS11 0.42 5.8 0.3 1.56e-8 Coronary artery disease; LUSC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.72 -0.39 1.34e-13 Height; LUSC cis rs3106136 0.546 rs4693003 chr4:95145469 A/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.46 -0.42 8.25e-16 Capecitabine sensitivity; LUSC cis rs9473147 0.516 rs10948363 chr6:47487762 A/G cg12968598 chr6:47444699 CD2AP 0.53 8.07 0.4 1.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 -0.4 -6.3 -0.33 9.27e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs7824557 0.628 rs11777746 chr8:11204755 T/C cg15556689 chr8:8085844 FLJ10661 0.5 7.23 0.37 3.26e-12 Retinal vascular caliber; LUSC cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg14552801 chr7:65878734 NA 0.38 5.93 0.31 7.69e-9 Aortic root size; LUSC cis rs6429082 0.608 rs4469707 chr1:235570634 T/C cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.86 -0.35 3.36e-11 Adiposity; LUSC cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.35 0.53 1.79e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 0.853 rs13256216 chr8:8577883 C/T cg00074818 chr8:8560427 CLDN23 0.58 9.43 0.46 7.04e-19 Obesity-related traits; LUSC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg26408565 chr15:76604113 ETFA -0.52 -8.3 -0.41 2.6e-15 Blood metabolite levels; LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg24829409 chr8:58192753 C8orf71 -0.53 -6.17 -0.32 1.98e-9 Developmental language disorder (linguistic errors); LUSC cis rs7493 0.950 rs11981299 chr7:95029701 T/A cg04871131 chr7:94954202 PON1 -0.38 -6.05 -0.31 3.79e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs782590 0.967 rs35504023 chr2:55806503 C/T cg18811423 chr2:55921094 PNPT1 -0.8 -13.48 -0.59 2.21e-33 Metabolic syndrome; LUSC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.64 -5.99 -0.31 5.32e-9 Cerebrospinal P-tau181p levels; LUSC cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg17892150 chr10:133769511 PPP2R2D -0.68 -9.46 -0.46 5.56e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs7786808 0.644 rs4909081 chr7:158200785 G/A cg02030672 chr11:45687055 CHST1 0.52 8.33 0.41 2.17e-15 Obesity-related traits; LUSC trans rs1493916 0.777 rs1941685 chr18:31304318 G/T cg27147174 chr7:100797783 AP1S1 -0.56 -8.76 -0.43 9.68e-17 Life satisfaction; LUSC cis rs10927875 0.632 rs4661666 chr1:16162471 C/A cg21385522 chr1:16154831 NA -1.02 -20.46 -0.75 6.88e-61 Dilated cardiomyopathy; LUSC cis rs7903847 0.596 rs10882934 chr10:99170995 T/G cg08345082 chr10:99160200 RRP12 -0.37 -7.51 -0.38 5.39e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 12.09 0.55 3.7e-28 Personality dimensions; LUSC cis rs6545883 0.929 rs1186711 chr2:61688505 T/C cg15711740 chr2:61764176 XPO1 -0.44 -6.67 -0.34 1.05e-10 Tuberculosis; LUSC cis rs1451375 0.785 rs10278338 chr7:50630270 C/T cg18232548 chr7:50535776 DDC 0.53 8.21 0.41 5.02e-15 Malaria; LUSC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg03452623 chr4:187889614 NA -0.88 -18.2 -0.71 6.32e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs6580649 0.941 rs1859441 chr12:48423233 C/T cg24011408 chr12:48396354 COL2A1 -0.52 -6.86 -0.35 3.35e-11 Lung cancer; LUSC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.16e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg06462663 chr19:18546047 ISYNA1 0.5 8.52 0.42 5.69e-16 Breast cancer; LUSC cis rs9303280 0.934 rs56380902 chr17:38066372 T/C cg10909506 chr17:38081995 ORMDL3 0.32 5.75 0.3 2.06e-8 Self-reported allergy; LUSC cis rs6060960 0.502 rs6057968 chr20:30082779 A/T cg13852791 chr20:30311386 BCL2L1 0.62 7.1 0.36 7.77e-12 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs868036 0.634 rs8028313 chr15:68043057 C/G cg27219399 chr15:67835830 MAP2K5 0.35 5.69 0.3 2.71e-8 Restless legs syndrome; LUSC cis rs644799 0.710 rs10831429 chr11:95508524 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.05 0.61 1.44e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs13315871 0.929 rs35376204 chr3:58325563 T/C cg12435725 chr3:58293450 RPP14 -0.72 -7.15 -0.36 5.35e-12 Cholesterol, total; LUSC cis rs6598955 0.694 rs4659416 chr1:26580937 T/G cg00852783 chr1:26633632 UBXN11 0.49 8.77 0.43 9.1e-17 Obesity-related traits; LUSC cis rs2688608 0.967 rs9971038 chr10:75661149 C/T cg17411546 chr10:75410026 SYNPO2L -0.42 -6.16 -0.32 2.05e-9 Inflammatory bowel disease; LUSC cis rs1865760 1.000 rs1865760 chr6:25916979 C/T cg16482183 chr6:26056742 HIST1H1C 0.44 6.49 0.33 3.11e-10 Height; LUSC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg25039879 chr17:56429692 SUPT4H1 0.5 7.04 0.36 1.07e-11 Cognitive test performance; LUSC cis rs6736093 0.966 rs3811634 chr2:112754943 C/T cg12686935 chr2:112915763 FBLN7 -0.37 -6.06 -0.31 3.65e-9 Coronary artery disease; LUSC cis rs7605827 0.897 rs13010658 chr2:15668468 A/G cg19274914 chr2:15703543 NA 0.45 8.5 0.42 6.45e-16 Educational attainment (years of education); LUSC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg07936489 chr17:37558343 FBXL20 -0.71 -9.84 -0.47 3.12e-20 Glomerular filtration rate (creatinine); LUSC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg12615879 chr12:58013172 SLC26A10 0.27 5.84 0.3 1.21e-8 Rheumatoid arthritis; LUSC cis rs11608355 0.515 rs12826754 chr12:109923244 A/G cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg17279839 chr7:150038598 RARRES2 0.41 6.31 0.33 8.98e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.26 -0.37 2.71e-12 Menopause (age at onset); LUSC cis rs6076065 0.723 rs2224074 chr20:23360171 G/C cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs453301 0.597 rs7001187 chr8:8792782 G/A cg15556689 chr8:8085844 FLJ10661 -0.63 -9.78 -0.47 5.12e-20 Joint mobility (Beighton score); LUSC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg13206674 chr6:150067644 NUP43 0.55 8.59 0.43 3.41e-16 Lung cancer; LUSC trans rs4332037 0.539 rs11763750 chr7:2080114 G/A cg25206134 chr2:45395956 NA 0.61 7.1 0.36 7.39e-12 Bipolar disorder; LUSC cis rs9467773 1.000 rs3736781 chr6:26505362 G/A cg09904177 chr6:26538194 HMGN4 0.73 13.27 0.59 1.45e-32 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.65 -0.34 1.23e-10 Lung cancer; LUSC trans rs1499614 1.000 rs2707830 chr7:66167645 T/C cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs561341 0.528 rs11650908 chr17:30195425 T/C cg13647721 chr17:30228624 UTP6 -0.6 -7.29 -0.37 2.27e-12 Hip circumference adjusted for BMI; LUSC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg02423579 chr7:2872169 GNA12 -0.41 -6.13 -0.32 2.43e-9 Height; LUSC trans rs61931739 0.500 rs11053213 chr12:34466395 G/T cg13010199 chr12:38710504 ALG10B 0.68 10.77 0.51 1.98e-23 Morning vs. evening chronotype; LUSC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg24733560 chr20:60626293 TAF4 0.41 6.77 0.35 5.69e-11 Body mass index; LUSC trans rs208520 0.837 rs208467 chr6:66914837 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -14.01 -0.61 2.11e-35 Exhaled nitric oxide output; LUSC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg25251562 chr2:3704773 ALLC 0.48 8.37 0.42 1.58e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12928939 0.815 rs7185575 chr16:71672569 A/G cg03805757 chr16:71968109 PKD1L3 -0.39 -5.66 -0.3 3.2e-8 Post bronchodilator FEV1; LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg05025164 chr4:1340916 KIAA1530 0.43 6.47 0.33 3.5e-10 Obesity-related traits; LUSC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg05729581 chr11:3078854 CARS -0.57 -8.86 -0.44 4.74e-17 Longevity; LUSC cis rs472402 0.580 rs6884552 chr5:6661966 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.44 -6.29 -0.33 9.9e-10 Response to amphetamines; LUSC cis rs9303401 0.646 rs8067682 chr17:57219391 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.47 7.24 0.37 3.03e-12 Cognitive test performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07029396 chr17:79650519 HGS;ARL16 -0.43 -6.31 -0.33 9.01e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28374715 0.532 rs316606 chr15:41772202 A/C cg18705301 chr15:41695430 NDUFAF1 -1.03 -20.95 -0.75 8.07e-63 Ulcerative colitis; LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg10802521 chr3:52805072 NEK4 -0.55 -8.68 -0.43 1.73e-16 Bipolar disorder; LUSC cis rs6430585 0.527 rs12467569 chr2:136413847 T/C cg07169764 chr2:136633963 MCM6 1.04 13.93 0.61 4.22e-35 Corneal structure; LUSC cis rs6087990 0.769 rs17123658 chr20:31390840 C/A cg13636640 chr20:31349939 DNMT3B 0.88 17.72 0.7 5.2e-50 Ulcerative colitis; LUSC trans rs11039798 0.925 rs7929225 chr11:48931739 G/C cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs10740039 0.804 rs7094818 chr10:62411971 G/C cg18175470 chr10:62150864 ANK3 -0.46 -6.85 -0.35 3.61e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11122272 0.668 rs1538664 chr1:231555295 C/T cg10503236 chr1:231470652 EXOC8 -0.35 -5.71 -0.3 2.49e-8 Hemoglobin concentration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05762101 chr4:1857817 LETM1 -0.41 -5.95 -0.31 6.78e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9905704 0.918 rs11650343 chr17:56919549 G/A cg12560992 chr17:57184187 TRIM37 0.56 7.86 0.4 5.16e-14 Testicular germ cell tumor; LUSC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.21 0.61 3.68e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs950027 0.584 rs1145086 chr15:45654327 A/G cg14582100 chr15:45693742 SPATA5L1 0.46 8.62 0.43 2.7e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs9341808 0.667 rs3828753 chr6:80912746 C/T cg08355045 chr6:80787529 NA 0.46 7.96 0.4 2.73e-14 Sitting height ratio; LUSC cis rs1580019 0.961 rs1580021 chr7:32497702 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.86 0.54 2.63e-27 Cognitive ability; LUSC cis rs11098499 0.722 rs1814814 chr4:120258124 C/G cg09307838 chr4:120376055 NA 0.7 11.21 0.52 5.5e-25 Corneal astigmatism; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg10862848 chr6:42927986 GNMT -0.25 -5.83 -0.3 1.31e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs709400 0.628 rs7155014 chr14:103863970 C/G cg12935359 chr14:103987150 CKB -0.55 -8.52 -0.42 5.69e-16 Body mass index; LUSC cis rs1538970 0.924 rs6657284 chr1:45879088 T/C cg06784218 chr1:46089804 CCDC17 0.32 5.68 0.3 2.96e-8 Platelet count; LUSC cis rs34779708 0.931 rs6481935 chr10:35342959 C/T cg04310649 chr10:35416472 CREM -0.41 -6.43 -0.33 4.53e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg11764359 chr7:65958608 NA -0.7 -10.85 -0.51 1.07e-23 Aortic root size; LUSC cis rs637571 0.528 rs566266 chr11:65573587 A/C cg10604040 chr11:65559109 OVOL1 0.31 5.78 0.3 1.72e-8 Eosinophil percentage of white cells; LUSC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg03351412 chr1:154909251 PMVK -0.55 -8.89 -0.44 3.75e-17 Prostate cancer; LUSC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs1595825 0.945 rs73056883 chr2:198824638 A/G cg00982548 chr2:198649783 BOLL -0.58 -7.29 -0.37 2.32e-12 Ulcerative colitis; LUSC cis rs2439831 0.850 rs3816792 chr15:44116986 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.84 -8.43 -0.42 1.01e-15 Lung cancer in ever smokers; LUSC cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg05340658 chr4:99064831 C4orf37 0.68 11.58 0.54 2.71e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg07703079 chr11:430292 ANO9 0.62 6.49 0.33 3.04e-10 Body mass index; LUSC cis rs5770917 1.000 rs12627787 chr22:51012381 C/T cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.62 -5.74 -0.3 2.07e-8 Narcolepsy; LUSC cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg19077165 chr18:44547161 KATNAL2 -0.38 -5.76 -0.3 1.94e-8 Personality dimensions; LUSC cis rs4285028 0.948 rs76593525 chr3:121690477 G/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.5 -0.46 4.26e-19 Multiple sclerosis; LUSC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg24324837 chr19:49891574 CCDC155 0.53 7.39 0.37 1.17e-12 Multiple sclerosis; LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs7613875 0.620 rs17657688 chr3:50033228 C/T cg21659725 chr3:3221576 CRBN -0.53 -8.4 -0.42 1.32e-15 Body mass index; LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -5.79 -0.3 1.62e-8 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg01879757 chr17:41196368 BRCA1 -0.46 -7.33 -0.37 1.71e-12 Menopause (age at onset); LUSC cis rs983392 0.709 rs1426250 chr11:60001325 A/G cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.12e-9 Alzheimer's disease (late onset); LUSC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg08499158 chr17:42289980 UBTF -0.49 -8.31 -0.41 2.46e-15 Total body bone mineral density; LUSC cis rs7909074 1.000 rs7079573 chr10:45400406 G/A cg04218760 chr10:45406644 TMEM72 -0.29 -7.05 -0.36 1.04e-11 Mean corpuscular volume; LUSC cis rs6430585 0.591 rs309170 chr2:136672775 C/T cg07169764 chr2:136633963 MCM6 1.03 15.82 0.65 1.87e-42 Corneal structure; LUSC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg15556689 chr8:8085844 FLJ10661 0.68 11.54 0.53 3.84e-26 Mood instability; LUSC cis rs2014572 1.000 rs2014572 chr19:57760018 G/A cg24459738 chr19:57751996 ZNF805 -0.51 -7.54 -0.38 4.56e-13 Hyperactive-impulsive symptoms; LUSC cis rs2760061 0.603 rs697762 chr1:228192410 G/A cg01973587 chr1:228161476 NA -0.36 -6.02 -0.31 4.61e-9 Diastolic blood pressure; LUSC cis rs2692947 0.655 rs4605406 chr2:96583735 A/C cg23100626 chr2:96804247 ASTL 0.3 6.9 0.35 2.7e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg21951975 chr1:209979733 IRF6 0.56 7.0 0.36 1.4e-11 Cleft lip with or without cleft palate; LUSC cis rs6546550 0.867 rs4401231 chr2:70063563 G/C cg02498382 chr2:70120550 SNRNP27 -0.29 -7.16 -0.36 5.13e-12 Prevalent atrial fibrillation; LUSC cis rs2795502 1.000 rs3121278 chr10:43375646 G/T cg20628663 chr10:43360327 NA 0.55 8.13 0.41 8.27e-15 Blood protein levels; LUSC cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg05283184 chr6:79620031 NA -0.58 -12.25 -0.56 9.76e-29 Intelligence (multi-trait analysis); LUSC cis rs9486719 0.857 rs4346856 chr6:96880270 C/T cg06623918 chr6:96969491 KIAA0776 0.79 11.74 0.54 6.98e-27 Migraine;Coronary artery disease; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg15572146 chr11:695533 TMEM80;DEAF1 0.39 5.94 0.31 7e-9 N-glycan levels; LUSC cis rs7107174 1.000 rs10899451 chr11:77991222 A/C cg02023728 chr11:77925099 USP35 0.49 6.8 0.35 4.83e-11 Testicular germ cell tumor; LUSC cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg13010199 chr12:38710504 ALG10B 0.67 10.99 0.52 3.34e-24 Heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00783759 chr4:128983441 LARP1B 0.43 6.05 0.31 3.92e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg00945038 chr17:61921165 SMARCD2 0.52 9.22 0.45 3.39e-18 Prudent dietary pattern; LUSC cis rs10791323 0.569 rs2187450 chr11:133743792 A/G cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg17264618 chr3:40429014 ENTPD3 0.31 6.79 0.35 5.01e-11 Renal cell carcinoma; LUSC cis rs1904096 0.506 rs6532476 chr4:95192461 C/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.45 -0.42 8.99e-16 Type 2 diabetes; LUSC trans rs61931739 0.517 rs11053063 chr12:34181011 C/T cg26384229 chr12:38710491 ALG10B 0.74 11.9 0.55 1.78e-27 Morning vs. evening chronotype; LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.83 0.63 1.46e-38 Platelet count; LUSC cis rs34779708 0.966 rs35079558 chr10:35479886 A/G cg04310649 chr10:35416472 CREM -0.42 -6.41 -0.33 5.11e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.5 -6.53 -0.34 2.5e-10 Renal function-related traits (BUN); LUSC cis rs2979489 0.891 rs2915590 chr8:30393334 A/G cg26383811 chr8:30366931 RBPMS -0.51 -8.44 -0.42 9.64e-16 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs8005677 0.962 rs11157931 chr14:23403193 A/C cg00579484 chr14:23475993 C14orf93 0.39 5.66 0.3 3.23e-8 Cognitive ability (multi-trait analysis); LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg00024416 chr22:24240387 NA -0.33 -5.77 -0.3 1.8e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1670533 1.000 rs7679432 chr4:1050521 G/A cg19318889 chr4:1322082 MAEA 0.43 5.66 0.3 3.22e-8 Recombination rate (females); LUSC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg26380479 chr7:97908229 NA -0.27 -6.0 -0.31 5e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg23172400 chr8:95962367 TP53INP1 0.35 6.7 0.34 8.71e-11 Type 2 diabetes; LUSC cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg26384229 chr12:38710491 ALG10B -0.82 -14.11 -0.61 8.58e-36 Bladder cancer; LUSC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg22535103 chr8:58192502 C8orf71 0.77 8.37 0.42 1.55e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs983392 0.868 rs7926954 chr11:59932579 G/A cg24026212 chr11:59952134 MS4A6A -0.36 -6.11 -0.32 2.82e-9 Alzheimer's disease (late onset); LUSC cis rs4911259 0.552 rs13038017 chr20:31467551 T/C cg13636640 chr20:31349939 DNMT3B -0.82 -15.9 -0.66 8.61e-43 Inflammatory bowel disease; LUSC trans rs953492 0.624 rs4469702 chr1:243365196 T/C cg01826367 chr1:224180288 NA -0.43 -6.33 -0.33 8.08e-10 Diastolic blood pressure; LUSC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs11048434 0.736 rs11048345 chr12:9123056 T/G cg23795048 chr12:9217529 LOC144571 0.33 5.64 0.3 3.56e-8 Sjögren's syndrome; LUSC cis rs11864453 0.612 rs12924413 chr16:72129745 T/C cg01557791 chr16:72042693 DHODH -0.43 -6.38 -0.33 6.06e-10 Fibrinogen levels; LUSC cis rs300703 0.542 rs443419 chr2:189800 C/T cg21211680 chr2:198530 NA -0.53 -6.81 -0.35 4.66e-11 Blood protein levels; LUSC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg12639453 chr1:2035780 PRKCZ -0.32 -6.86 -0.35 3.35e-11 Height; LUSC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs6840360 0.554 rs10222838 chr4:152690099 T/C cg22705602 chr4:152727874 NA -0.39 -8.52 -0.42 5.42e-16 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg06873352 chr17:61820015 STRADA 0.7 12.64 0.57 3.53e-30 Prudent dietary pattern; LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg15790184 chr11:494944 RNH1 0.55 6.2 0.32 1.67e-9 Body mass index; LUSC cis rs11098499 0.604 rs2389887 chr4:120570644 T/C cg09307838 chr4:120376055 NA 0.7 9.88 0.48 2.23e-20 Corneal astigmatism; LUSC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg04398451 chr17:18023971 MYO15A 0.45 7.02 0.36 1.22e-11 Total body bone mineral density; LUSC cis rs8180040 0.966 rs807932 chr3:47354241 C/T cg16586182 chr3:47516702 SCAP -0.48 -7.46 -0.38 7.78e-13 Colorectal cancer; LUSC trans rs72674100 1.000 rs6830382 chr4:97977606 G/A cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg12751644 chr20:60527061 NA 0.43 7.45 0.38 7.94e-13 Obesity-related traits; LUSC cis rs61931739 0.736 rs7314457 chr12:34454301 G/A cg06521331 chr12:34319734 NA -0.35 -5.78 -0.3 1.67e-8 Morning vs. evening chronotype; LUSC trans rs11039798 0.588 rs589834 chr11:48419382 C/G cg15704280 chr7:45808275 SEPT13 -0.62 -6.78 -0.35 5.33e-11 Axial length; LUSC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg26116260 chr4:7069785 GRPEL1 -1.02 -11.22 -0.52 5.21e-25 Monocyte percentage of white cells; LUSC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg10130564 chr11:117069849 TAGLN 0.37 6.05 0.31 3.94e-9 Blood protein levels; LUSC cis rs1957429 0.522 rs57319601 chr14:65415743 C/T cg23373153 chr14:65346875 NA -0.78 -6.53 -0.34 2.4e-10 Pediatric areal bone mineral density (radius); LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg24060327 chr5:131705240 SLC22A5 -0.51 -8.18 -0.41 6.15e-15 Acylcarnitine levels; LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC trans rs61931739 0.686 rs708145 chr12:33731580 G/A cg26384229 chr12:38710491 ALG10B 0.43 6.18 0.32 1.9e-9 Morning vs. evening chronotype; LUSC cis rs28647808 0.881 rs4962139 chr9:136267869 C/T cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A 0.56 5.67 0.3 3.04e-8 Blood protein levels; LUSC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg26441486 chr22:50317300 CRELD2 0.5 7.3 0.37 2.06e-12 Schizophrenia; LUSC cis rs7000551 0.505 rs4872499 chr8:22293306 A/G cg12081754 chr8:22256438 SLC39A14 -0.86 -11.84 -0.54 3.11e-27 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs908922 0.651 rs4240886 chr1:152530396 A/T cg20991723 chr1:152506922 NA -0.48 -9.09 -0.45 8.99e-18 Hair morphology; LUSC cis rs2976388 0.967 rs2976393 chr8:143763618 C/G cg17252645 chr8:143867129 LY6D -0.37 -6.34 -0.33 7.38e-10 Urinary tract infection frequency; LUSC cis rs6696846 0.515 rs6593924 chr1:205110452 A/G cg00857998 chr1:205179979 DSTYK 0.45 6.31 0.33 9.09e-10 Red blood cell count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08902025 chr16:85646717 KIAA0182 -0.41 -6.28 -0.32 1.07e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg00071950 chr4:10020882 SLC2A9 -0.49 -8.14 -0.41 7.8e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12595990 chr12:49351331 ARF3 -0.42 -6.52 -0.34 2.63e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7119 0.604 rs2682921 chr15:77865459 C/T cg27398640 chr15:77910606 LINGO1 0.35 7.85 0.39 5.57e-14 Type 2 diabetes; LUSC cis rs2842992 0.747 rs4709378 chr6:160227435 G/C cg25282410 chr6:160211355 TCP1;MRPL18 1.13 16.52 0.67 3.08e-45 Age-related macular degeneration (geographic atrophy); LUSC cis rs9420 0.961 rs11607056 chr11:57496820 C/T cg02958346 chr11:57425731 CLP1 -0.43 -6.28 -0.32 1.06e-9 Schizophrenia; LUSC cis rs35424364 1 rs35424364 chr6:109643605 A/AT cg12927641 chr6:109611667 NA -0.54 -6.23 -0.32 1.41e-9 Obstructive sleep apnea trait (average respiratory event duration); LUSC cis rs7100689 0.646 rs2095994 chr10:82127956 G/A cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg19539972 chr4:7069911 GRPEL1 0.72 9.06 0.44 1.13e-17 Monocyte percentage of white cells; LUSC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg03929089 chr4:120376271 NA -0.94 -16.31 -0.67 2.11e-44 Height; LUSC cis rs662064 0.962 rs596537 chr1:10554709 G/T cg17425144 chr1:10567563 PEX14 0.36 5.79 0.3 1.59e-8 Asthma; LUSC cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg16797656 chr11:68205561 LRP5 0.35 5.83 0.3 1.28e-8 Total body bone mineral density; LUSC cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg16339924 chr4:17578868 LAP3 0.6 8.95 0.44 2.44e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs56804039 1.000 rs59620654 chr8:8382632 A/G cg15556689 chr8:8085844 FLJ10661 -0.58 -7.38 -0.37 1.27e-12 Cervical cancer; LUSC cis rs11971779 0.618 rs3778931 chr7:139102490 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs71017072 1 rs71017072 chr7:19794295 G/GA cg05791153 chr7:19748676 TWISTNB 0.66 7.1 0.36 7.62e-12 Rubella; LUSC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg23281280 chr6:28129359 ZNF389 0.44 5.74 0.3 2.17e-8 Depression; LUSC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg02896835 chr1:92012615 NA -0.65 -11.7 -0.54 9.9e-27 Breast cancer; LUSC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg24733560 chr20:60626293 TAF4 -0.43 -7.98 -0.4 2.35e-14 Body mass index; LUSC trans rs4332037 0.802 rs73048106 chr7:1929019 G/T cg10840412 chr1:235813424 GNG4 0.67 8.37 0.42 1.64e-15 Bipolar disorder; LUSC cis rs6062509 0.965 rs2315008 chr20:62343956 T/G cg21849932 chr20:62369462 LIME1 -0.41 -6.1 -0.32 2.94e-9 Prostate cancer; LUSC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.35 0.33 7.19e-10 Renal cell carcinoma; LUSC cis rs9430161 0.644 rs34365965 chr1:11034442 G/A cg02454025 chr1:11042201 C1orf127 1.02 18.51 0.71 3.88e-53 Ewing sarcoma; LUSC cis rs1670533 1.000 rs6812586 chr4:1069851 A/G cg02018176 chr4:1364513 KIAA1530 0.45 6.37 0.33 6.14e-10 Recombination rate (females); LUSC cis rs1577917 1.000 rs12207305 chr6:86723502 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.22 -0.41 4.54e-15 Response to antipsychotic treatment; LUSC cis rs10908458 0.808 rs10908456 chr1:155086148 A/G cg23973274 chr1:155060172 NA 0.3 5.74 0.3 2.09e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg08280861 chr8:58055591 NA 0.56 5.98 0.31 5.87e-9 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg08736216 chr1:53307985 ZYG11A -0.31 -6.39 -0.33 5.68e-10 Monocyte count; LUSC cis rs7582180 0.629 rs36103184 chr2:100942634 G/A cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.53 -7.14 -0.36 5.85e-12 Renal function-related traits (BUN); LUSC cis rs950169 0.800 rs4099846 chr15:84956894 C/G cg17173187 chr15:85201210 NMB 0.37 6.4 0.33 5.31e-10 Schizophrenia; LUSC cis rs30380 0.587 rs30185 chr5:96125465 G/A cg16492584 chr5:96139282 ERAP1 -0.52 -7.05 -0.36 1e-11 Cerebrospinal fluid biomarker levels; LUSC cis rs12519773 0.576 rs55971857 chr5:92441594 A/C cg18783429 chr5:92414398 NA 0.31 6.08 0.32 3.23e-9 Migraine; LUSC cis rs240764 0.658 rs9377214 chr6:101212146 G/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.26 -0.32 1.21e-9 Neuroticism; LUSC cis rs4919087 0.892 rs10786319 chr10:99008951 T/C cg25902810 chr10:99078978 FRAT1 0.44 6.45 0.33 3.97e-10 Monocyte count; LUSC trans rs1908814 0.516 rs56102998 chr8:11796675 G/A cg06636001 chr8:8085503 FLJ10661 0.54 7.98 0.4 2.44e-14 Neuroticism; LUSC trans rs208520 0.802 rs208499 chr6:66932146 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -13.71 -0.6 2.88e-34 Exhaled nitric oxide output; LUSC trans rs61931739 0.658 rs4476006 chr12:34237154 A/C cg13010199 chr12:38710504 ALG10B 0.4 6.38 0.33 5.88e-10 Morning vs. evening chronotype; LUSC cis rs6546550 0.901 rs11126251 chr2:70163434 A/C cg02498382 chr2:70120550 SNRNP27 -0.32 -8.2 -0.41 5.12e-15 Prevalent atrial fibrillation; LUSC cis rs3096299 0.746 rs9931120 chr16:89501357 A/G cg06640241 chr16:89574553 SPG7 0.82 13.87 0.6 7.35e-35 Multiple myeloma (IgH translocation); LUSC trans rs62103177 0.564 rs2115996 chr18:77701007 C/G cg14227996 chr4:17616232 MED28 0.67 7.12 0.36 6.76e-12 Opioid sensitivity; LUSC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.14 -0.49 3.12e-21 Developmental language disorder (linguistic errors); LUSC cis rs10089 1.000 rs13355233 chr5:127425350 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.87 -12.56 -0.57 6.5e-30 Ileal carcinoids; LUSC cis rs3743266 0.613 rs8027901 chr15:60733464 A/C cg21667061 chr15:60772094 NARG2 -0.38 -6.3 -0.33 9.15e-10 Menarche (age at onset); LUSC cis rs9463078 0.739 rs1041333 chr6:44945206 A/T cg25276700 chr6:44698697 NA -0.29 -5.87 -0.31 1.06e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs367943 0.712 rs7734061 chr5:112700175 A/G cg12552261 chr5:112820674 MCC 0.4 6.54 0.34 2.31e-10 Type 2 diabetes; LUSC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg06600287 chr1:53387719 ECHDC2 -0.3 -6.18 -0.32 1.91e-9 Monocyte count; LUSC cis rs9341808 0.754 rs10806185 chr6:80954511 G/A cg08355045 chr6:80787529 NA 0.56 9.62 0.47 1.7e-19 Sitting height ratio; LUSC cis rs11122272 0.735 rs2790884 chr1:231531932 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.27 -0.49 1.14e-21 Hemoglobin concentration; LUSC cis rs11077998 0.844 rs8064433 chr17:80501046 A/T cg10255544 chr17:80519551 FOXK2 0.41 6.69 0.34 9.59e-11 Reticulocyte fraction of red cells; LUSC cis rs10857712 0.754 rs1052582 chr10:135233840 C/G cg01444801 chr10:135216882 MTG1 -0.48 -6.4 -0.33 5.18e-10 Systemic lupus erythematosus; LUSC cis rs7590368 0.715 rs56162318 chr2:10958936 A/C cg15705551 chr2:10952987 PDIA6 0.58 6.24 0.32 1.31e-9 Educational attainment (years of education); LUSC cis rs9309473 0.748 rs2421552 chr2:73758803 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.53 -0.34 2.45e-10 Metabolite levels; LUSC cis rs738322 0.967 rs133018 chr22:38572761 G/A cg25457927 chr22:38595422 NA -0.41 -8.73 -0.43 1.24e-16 Cutaneous nevi; LUSC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg24399712 chr22:39784796 NA -0.58 -9.38 -0.46 1.02e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg01017244 chr2:74357527 NA 0.74 14.39 0.62 7.35e-37 Gestational age at birth (maternal effect); LUSC trans rs4650994 0.544 rs2761469 chr1:178590638 A/C cg05059571 chr16:84539110 KIAA1609 0.46 8.76 0.43 9.66e-17 HDL cholesterol levels;HDL cholesterol; LUSC trans rs8073060 0.586 rs225278 chr17:33974170 C/T cg19694781 chr19:47549865 TMEM160 -1.14 -17.81 -0.7 2.27e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg08807101 chr21:30365312 RNF160 -0.72 -12.81 -0.57 7.8e-31 Dental caries; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04105453 chr2:27440337 CAD -0.52 -6.2 -0.32 1.68e-9 Bipolar disorder and schizophrenia; LUSC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg23172400 chr8:95962367 TP53INP1 -0.41 -8.19 -0.41 5.46e-15 Type 2 diabetes; LUSC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.69e-14 Systolic blood pressure; LUSC trans rs1908814 0.516 rs13281315 chr8:11794855 C/G cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.76e-9 Neuroticism; LUSC cis rs6582630 0.555 rs11180986 chr12:38264486 G/A cg26384229 chr12:38710491 ALG10B -0.57 -8.58 -0.42 3.69e-16 Drug-induced liver injury (flucloxacillin); LUSC trans rs2204008 0.748 rs7312204 chr12:38334909 T/C cg06521331 chr12:34319734 NA -0.4 -6.21 -0.32 1.6e-9 Bladder cancer; LUSC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg27286337 chr10:134555280 INPP5A 0.81 10.76 0.51 2.19e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs656319 0.580 rs13252589 chr8:10005526 A/G cg27411982 chr8:10470053 RP1L1 -0.43 -6.58 -0.34 1.8e-10 Myopia (pathological); LUSC cis rs5769707 0.837 rs1573726 chr22:50032872 G/A cg20744362 chr22:50050164 C22orf34 0.38 7.87 0.4 4.97e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7258465 1.000 rs271621 chr19:18631332 C/A cg06462663 chr19:18546047 ISYNA1 0.44 7.47 0.38 6.97e-13 Breast cancer; LUSC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg11764359 chr7:65958608 NA 0.52 6.85 0.35 3.5e-11 Aortic root size; LUSC cis rs7568458 0.709 rs1446669 chr2:85762209 T/C cg23752985 chr2:85803571 VAMP8 0.32 6.27 0.32 1.11e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2370759 1.000 rs11599044 chr10:32615445 A/G cg01819863 chr10:32635814 EPC1 1.05 13.17 0.58 3.32e-32 Sexual dysfunction (female); LUSC cis rs77372450 0.636 rs10057597 chr5:157012870 A/G cg25387487 chr5:157003181 ADAM19 -0.47 -5.67 -0.3 3.13e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2717559 0.522 rs35816096 chr8:143884938 C/T cg07661805 chr8:143867942 LY6D -0.26 -5.91 -0.31 8.23e-9 Urinary tract infection frequency; LUSC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.546 rs7679681 chr4:98882221 A/G cg03676636 chr4:99064102 C4orf37 0.31 6.23 0.32 1.44e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1728785 1.000 rs889561 chr16:68605741 G/A cg02972257 chr16:68554789 NA -0.54 -6.73 -0.35 7.29e-11 Ulcerative colitis; LUSC cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.69 0.83 1.71e-88 Chronic sinus infection; LUSC cis rs35146811 0.844 rs12705071 chr7:99682026 T/C cg22906224 chr7:99728672 NA 0.54 7.25 0.37 2.96e-12 Coronary artery disease; LUSC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg14403583 chr14:105418241 AHNAK2 -0.58 -9.71 -0.47 8.69e-20 Rheumatoid arthritis; LUSC cis rs17095355 1.000 rs72828241 chr10:111744704 T/A cg00817464 chr10:111662876 XPNPEP1 -0.65 -7.58 -0.38 3.53e-13 Biliary atresia; LUSC cis rs7615952 0.736 rs9862893 chr3:125686974 A/G cg15145296 chr3:125709740 NA -0.59 -5.96 -0.31 6.41e-9 Blood pressure (smoking interaction); LUSC cis rs1953600 0.870 rs2245168 chr10:81921918 T/C cg00277334 chr10:82204260 NA -0.44 -6.85 -0.35 3.5e-11 Sarcoidosis; LUSC cis rs3126085 0.735 rs4845744 chr1:152185095 T/A cg26876637 chr1:152193138 HRNR 0.42 5.96 0.31 6.41e-9 Atopic dermatitis; LUSC cis rs6060717 0.698 rs8123175 chr20:34609872 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.57 -0.34 1.98e-10 Hip circumference adjusted for BMI; LUSC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg09835421 chr16:68378352 PRMT7 -0.54 -6.09 -0.32 3.03e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg11189052 chr15:85197271 WDR73 0.47 5.93 0.31 7.41e-9 Schizophrenia; LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg05165339 chr4:1420672 NA -0.29 -6.83 -0.35 3.94e-11 Longevity; LUSC cis rs1448094 0.967 rs10863118 chr12:86339232 C/G cg00310523 chr12:86230176 RASSF9 0.4 7.31 0.37 1.94e-12 Major depressive disorder; LUSC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg26441486 chr22:50317300 CRELD2 -0.52 -7.81 -0.39 7.65e-14 Schizophrenia; LUSC cis rs7561273 0.586 rs7580772 chr2:24357657 T/C cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs2625529 0.730 rs7403191 chr15:72160964 C/T cg16672083 chr15:72433130 SENP8 -0.49 -7.86 -0.4 5.4e-14 Red blood cell count; LUSC trans rs1998174 0.509 rs742510 chr1:171828070 C/T cg13482142 chr2:234261155 NA -0.42 -6.12 -0.32 2.66e-9 Platelet distribution width; LUSC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg27170947 chr2:26402098 FAM59B -0.63 -9.18 -0.45 4.77e-18 Gut microbiome composition (summer); LUSC cis rs28735056 0.904 rs62103174 chr18:77621048 A/G cg20368463 chr18:77673604 PQLC1 0.48 6.81 0.35 4.64e-11 Schizophrenia; LUSC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg14829360 chr17:73884958 NA -0.36 -5.93 -0.31 7.59e-9 White matter hyperintensity burden; LUSC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg09650180 chr20:62225654 GMEB2 -0.67 -9.59 -0.46 2.11e-19 Glioblastoma; LUSC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg08219700 chr8:58056026 NA 0.45 5.78 0.3 1.71e-8 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.505 rs75122014 chr4:120362426 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.14 0.32 2.4e-9 Corneal astigmatism; LUSC cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.68 -0.34 9.95e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2762353 0.935 rs1185567 chr6:25818588 A/G cg12310025 chr6:25882481 NA -0.45 -7.82 -0.39 7.19e-14 Blood metabolite levels; LUSC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg05234568 chr11:5960015 NA -0.68 -11.36 -0.53 1.72e-25 DNA methylation (variation); LUSC cis rs13006833 0.668 rs291453 chr2:191160196 G/A cg21644426 chr2:191273491 MFSD6 0.47 6.76 0.35 6.15e-11 Urinary metabolites; LUSC cis rs73198271 0.740 rs1039912 chr8:8648229 C/T cg01851573 chr8:8652454 MFHAS1 0.55 7.74 0.39 1.18e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs17253792 0.822 rs10483643 chr14:56089931 G/C cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs2267681 0.544 rs4726838 chr7:139516964 T/C cg14116596 chr7:139528673 TBXAS1 0.37 6.42 0.33 4.77e-10 Cervical cancer; LUSC cis rs9534288 0.699 rs2146886 chr13:46646711 C/T cg15192986 chr13:46630673 CPB2 -0.77 -11.48 -0.53 6.23e-26 Blood protein levels; LUSC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg02574844 chr11:5959923 NA -0.42 -5.88 -0.31 1.01e-8 DNA methylation (variation); LUSC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC trans rs7824557 0.564 rs2572379 chr8:11237480 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.47 -0.38 7.29e-13 Retinal vascular caliber; LUSC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg21724239 chr8:58056113 NA 0.54 6.26 0.32 1.19e-9 Developmental language disorder (linguistic errors); LUSC cis rs3768617 0.510 rs4651142 chr1:183097386 A/T ch.1.3577855R chr1:183094577 LAMC1 0.72 10.95 0.51 4.95e-24 Fuchs's corneal dystrophy; LUSC cis rs6940638 0.688 rs9461335 chr6:27138529 C/A cg12292205 chr6:26970375 C6orf41 -0.39 -5.83 -0.3 1.29e-8 Intelligence (multi-trait analysis); LUSC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.64 8.35 0.42 1.78e-15 Schizophrenia; LUSC cis rs2219968 0.828 rs13265358 chr8:78930198 T/C cg00738934 chr8:78996279 NA -0.42 -7.56 -0.38 4.05e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs7712401 0.607 rs246270 chr5:122258649 T/C cg19077854 chr5:122220652 SNX24 0.42 9.25 0.45 2.81e-18 Mean platelet volume; LUSC cis rs7089973 0.604 rs11196924 chr10:116571796 A/C cg23260525 chr10:116636907 FAM160B1 -0.4 -8.34 -0.42 1.94e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg16339924 chr4:17578868 LAP3 -0.52 -7.66 -0.39 2.03e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg02339015 chr20:62561062 DNAJC5 -0.41 -6.23 -0.32 1.39e-9 N-glycan levels; LUSC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg22875332 chr1:76189707 ACADM 0.86 15.74 0.65 3.91e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs73198271 0.562 rs113730597 chr8:8651573 G/A cg01851573 chr8:8652454 MFHAS1 0.59 8.03 0.4 1.69e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs983392 0.679 rs7930318 chr11:60033371 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.11 0.32 2.83e-9 Alzheimer's disease (late onset); LUSC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg03709012 chr19:19516395 GATAD2A -0.83 -13.92 -0.61 4.6e-35 Tonsillectomy; LUSC cis rs1670533 0.932 rs2045067 chr4:1052355 C/T cg02018176 chr4:1364513 KIAA1530 0.46 6.49 0.33 3.12e-10 Recombination rate (females); LUSC cis rs7524258 0.868 rs2412152 chr1:7303213 C/T cg07173049 chr1:7289937 CAMTA1 0.35 7.2 0.37 3.98e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.14 -0.32 2.36e-9 Life satisfaction; LUSC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.58 12.08 0.55 3.96e-28 Hemoglobin concentration; LUSC cis rs9359856 0.673 rs1179901 chr6:90321196 C/T cg13799429 chr6:90582589 CASP8AP2 -0.76 -8.2 -0.41 5.22e-15 Bipolar disorder; LUSC cis rs6690583 0.524 rs6680422 chr1:85451945 C/T cg22153463 chr1:85462885 MCOLN2 0.63 6.04 0.31 4.1e-9 Serum sulfate level; LUSC cis rs7927592 0.871 rs12941 chr11:68382193 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.76 -0.3 1.92e-8 Total body bone mineral density; LUSC cis rs5758511 0.731 rs58302269 chr22:42351309 G/A cg00645731 chr22:42541494 CYP2D7P1 0.45 7.29 0.37 2.19e-12 Birth weight; LUSC cis rs9355610 0.927 rs2757041 chr6:167370532 C/G cg25258033 chr6:167368657 RNASET2 -0.36 -5.69 -0.3 2.79e-8 Graves' disease; LUSC trans rs7746199 0.736 rs13192965 chr6:27671825 G/A cg06606381 chr12:133084897 FBRSL1 -0.95 -8.61 -0.43 2.88e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs73198271 0.515 rs76653757 chr8:8624901 C/A cg01851573 chr8:8652454 MFHAS1 0.62 7.15 0.36 5.52e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg24399712 chr22:39784796 NA -0.63 -11.44 -0.53 8.66e-26 Intelligence (multi-trait analysis); LUSC cis rs6061231 0.505 rs13037253 chr20:60928724 G/A cg06026331 chr20:60912101 LAMA5 0.59 6.98 0.36 1.55e-11 Colorectal cancer; LUSC cis rs9653442 0.564 rs4850924 chr2:100782273 A/G cg07810366 chr2:100720526 AFF3 -0.43 -7.26 -0.37 2.68e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4851254 0.660 rs10209201 chr2:100672808 C/T cg07810366 chr2:100720526 AFF3 -0.45 -6.04 -0.31 4.06e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg08470875 chr2:26401718 FAM59B 0.67 8.65 0.43 2.26e-16 Gut microbiome composition (summer); LUSC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg22549504 chr19:17448937 GTPBP3 0.56 7.3 0.37 2.1e-12 Systemic lupus erythematosus; LUSC trans rs7824557 0.545 rs2736303 chr8:11236850 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.47 -0.38 7.29e-13 Retinal vascular caliber; LUSC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg21724239 chr8:58056113 NA 0.79 9.43 0.46 7.13e-19 Developmental language disorder (linguistic errors); LUSC cis rs926938 0.618 rs1286555 chr1:115361896 C/T cg12756093 chr1:115239321 AMPD1 -0.5 -7.15 -0.36 5.59e-12 Autism; LUSC cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg05855489 chr10:104503620 C10orf26 0.69 10.15 0.49 2.93e-21 Arsenic metabolism; LUSC cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg22709100 chr7:91322751 NA 0.39 5.8 0.3 1.56e-8 Breast cancer; LUSC cis rs548181 0.545 rs4486648 chr11:125610589 T/A cg03464685 chr11:125439445 EI24 -0.92 -11.03 -0.52 2.57e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1800795 0.901 rs2069833 chr7:22767664 C/T cg26061582 chr7:22766209 IL6 0.51 7.4 0.38 1.12e-12 Cerebrospinal fluid clusterin levels in APOEe4- carriers; LUSC cis rs7772486 0.875 rs2492855 chr6:146296926 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.97 -0.36 1.74e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg19592336 chr6:28129416 ZNF389 0.46 6.14 0.32 2.37e-9 Depression; LUSC cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.68 -0.34 9.79e-11 Monocyte percentage of white cells; LUSC cis rs77633900 0.772 rs284884 chr15:76828289 A/G cg21673338 chr15:77095150 SCAPER -0.67 -5.71 -0.3 2.53e-8 Non-glioblastoma glioma;Glioma; LUSC cis rs2439831 0.867 rs2243434 chr15:43689867 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 3.93e-19 Lung cancer in ever smokers; LUSC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg07741184 chr6:167504864 NA -0.37 -6.73 -0.35 7.26e-11 Crohn's disease; LUSC cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg20503657 chr10:835505 NA 0.63 7.93 0.4 3.38e-14 Eosinophil percentage of granulocytes; LUSC cis rs4803468 0.967 rs11083619 chr19:41913267 A/C cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.42 5.75 0.3 1.98e-8 Height; LUSC cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.2 0.64 5.05e-40 Bladder cancer; LUSC trans rs10506458 0.915 rs56321182 chr12:63392023 C/T cg22491629 chr6:157744540 C6orf35 -0.91 -10.89 -0.51 7.95e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs886126 0.901 rs10744770 chr12:111662578 G/A cg10833066 chr12:111807467 FAM109A 0.39 6.1 0.32 2.99e-9 Coronary heart disease; LUSC cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg21433313 chr16:3507492 NAT15 0.41 6.34 0.33 7.29e-10 Body mass index (adult); LUSC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.42 -0.38 9.56e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs11637445 0.603 rs7183168 chr15:68121483 A/C cg08079166 chr15:68083412 MAP2K5 0.35 7.33 0.37 1.76e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg10909506 chr17:38081995 ORMDL3 0.33 5.77 0.3 1.86e-8 Self-reported allergy; LUSC cis rs2235649 0.833 rs9929262 chr16:1851928 T/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.42 -6.02 -0.31 4.48e-9 Blood metabolite levels; LUSC trans rs7939886 0.623 rs77065109 chr11:55906843 G/A cg15704280 chr7:45808275 SEPT13 0.83 6.68 0.34 9.8e-11 Myopia (pathological); LUSC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg18135555 chr8:22132992 PIWIL2 -0.38 -7.73 -0.39 1.29e-13 Hypertriglyceridemia; LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.87 -0.31 1.07e-8 Platelet count; LUSC cis rs9527 0.590 rs11191572 chr10:104893137 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg17724175 chr1:150552817 MCL1 0.37 6.77 0.35 5.97e-11 Tonsillectomy; LUSC cis rs2286503 0.809 rs4719716 chr7:22861369 G/A cg11367502 chr7:22862612 TOMM7 0.46 6.17 0.32 1.96e-9 Fibrinogen; LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.47 0.42 7.64e-16 Prudent dietary pattern; LUSC cis rs921665 0.831 rs11688404 chr2:3188755 C/T cg02624386 chr2:3182749 NA 0.51 5.79 0.3 1.6e-8 World class endurance athleticism; LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg01802117 chr1:53393560 SCP2 -0.38 -6.51 -0.34 2.71e-10 Monocyte count; LUSC cis rs6960043 0.818 rs1558318 chr7:15065612 A/T cg19272540 chr7:15055459 NA -0.28 -6.84 -0.35 3.8e-11 Type 2 diabetes; LUSC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg07952391 chr2:88470173 THNSL2 0.75 6.49 0.33 3.06e-10 Plasma clusterin levels; LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.54 -9.34 -0.46 1.4e-18 Bipolar disorder; LUSC cis rs12618769 0.597 rs72820002 chr2:99075259 T/A cg10123293 chr2:99228465 UNC50 0.45 7.65 0.39 2.17e-13 Bipolar disorder; LUSC trans rs9630182 0.561 rs11022810 chr11:13438245 T/C cg00234616 chr2:74740572 TLX2 0.3 5.96 0.31 6.25e-9 Bone mineral density; LUSC cis rs7927771 0.542 rs6485775 chr11:47773518 A/G cg20307385 chr11:47447363 PSMC3 -0.43 -6.25 -0.32 1.22e-9 Subjective well-being; LUSC cis rs2625529 0.627 rs12898585 chr15:72473928 T/C cg16672083 chr15:72433130 SENP8 -0.49 -7.54 -0.38 4.44e-13 Red blood cell count; LUSC cis rs41271473 0.526 rs942853 chr1:228730949 G/T cg10167378 chr1:228756711 NA 0.76 9.78 0.47 5.16e-20 Chronic lymphocytic leukemia; LUSC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC trans rs7395662 1.000 rs4929903 chr11:48913332 T/G cg00717180 chr2:96193071 NA -0.38 -6.02 -0.31 4.55e-9 HDL cholesterol; LUSC trans rs1728785 0.901 rs933713 chr16:68581378 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg06784218 chr1:46089804 CCDC17 0.54 10.91 0.51 6.6e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11583043 1.000 rs6700743 chr1:101447384 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 6.2 0.32 1.65e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs10791097 0.694 rs876641 chr11:130752040 A/C cg12179176 chr11:130786555 SNX19 0.85 14.99 0.63 3.21e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.69 -0.3 2.73e-8 Bipolar disorder; LUSC cis rs2227564 0.597 rs2633305 chr10:75652123 A/G cg23231163 chr10:75533350 FUT11 -0.42 -5.89 -0.31 9.32e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2486288 0.656 rs11632419 chr15:45557456 C/A cg09092052 chr15:45571596 NA 0.45 6.3 0.33 9.44e-10 Glomerular filtration rate; LUSC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg13939156 chr17:80058883 NA -0.34 -6.76 -0.35 6.08e-11 Life satisfaction; LUSC cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg26384229 chr12:38710491 ALG10B 0.89 15.26 0.64 2.9e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg06784218 chr1:46089804 CCDC17 0.56 11.33 0.53 2.06e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg12564285 chr5:131593104 PDLIM4 0.47 8.25 0.41 3.63e-15 Breast cancer; LUSC cis rs7264396 0.887 rs224364 chr20:34063865 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.44 -0.33 4.26e-10 Total cholesterol levels; LUSC trans rs1997103 0.822 rs940878 chr7:55419663 A/G cg20935933 chr6:143382018 AIG1 0.48 6.44 0.33 4.19e-10 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6076065 1.000 rs2424553 chr20:23403939 A/G cg11657817 chr20:23433608 CST11 0.38 7.12 0.36 6.67e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs7833986 0.501 rs17814658 chr8:56989130 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.32 0.56 5.06e-29 Height; LUSC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg16049864 chr8:95962084 TP53INP1 -0.63 -11.83 -0.54 3.3699999999999996e-27 Type 2 diabetes; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg08305872 chr2:210867207 RPE 0.43 6.0 0.31 5.12e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg07092213 chr7:1199455 ZFAND2A -0.61 -9.6 -0.47 1.91e-19 Longevity;Endometriosis; LUSC cis rs7829975 0.606 rs6422352 chr8:8794193 A/G cg15556689 chr8:8085844 FLJ10661 -0.61 -10.3 -0.49 8.92e-22 Mood instability; LUSC cis rs4588572 0.606 rs4290994 chr5:77742253 C/T cg11547950 chr5:77652471 NA -0.46 -6.74 -0.35 7.08e-11 Triglycerides; LUSC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.28 0.45 2.17e-18 Total body bone mineral density; LUSC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg16060761 chr17:80687452 NA -0.53 -8.03 -0.4 1.63e-14 Glycated hemoglobin levels; LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg26314531 chr2:26401878 FAM59B 0.69 9.49 0.46 4.66e-19 Gut microbiome composition (summer); LUSC cis rs6906287 0.647 rs3951042 chr6:118722495 C/T cg21191810 chr6:118973309 C6orf204 0.34 6.12 0.32 2.64e-9 Electrocardiographic conduction measures; LUSC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.53 -5.74 -0.3 2.09e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs4853525 0.522 rs6744420 chr2:191589082 A/G cg11845111 chr2:191398756 TMEM194B 0.43 5.82 0.3 1.39e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22307029 chr19:49891270 CCDC155 0.67 9.53 0.46 3.3e-19 Multiple sclerosis; LUSC trans rs1508086 0.935 rs12676415 chr8:57813418 A/G cg01310875 chr8:27938995 C8orf80 -0.31 -6.75 -0.35 6.62e-11 Hand grip strength; LUSC cis rs829883 1.000 rs829883 chr12:98879606 G/A cg25150519 chr12:98850993 NA 0.64 10.02 0.48 7.74e-21 Colorectal adenoma (advanced); LUSC trans rs1814175 0.645 rs7123448 chr11:49764865 T/G cg03929089 chr4:120376271 NA -0.93 -16.15 -0.66 9.42e-44 Height; LUSC cis rs113835537 0.529 rs11227511 chr11:66281244 A/C cg24851651 chr11:66362959 CCS 0.54 8.12 0.41 8.9e-15 Airway imaging phenotypes; LUSC trans rs877282 0.898 rs11253346 chr10:765313 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs11677416 0.961 rs1894399 chr2:113540177 C/T cg27083787 chr2:113543245 IL1A 0.45 7.16 0.36 5.05e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs870825 0.616 rs4616798 chr4:185634144 C/T cg04058563 chr4:185651563 MLF1IP -0.81 -12.68 -0.57 2.49e-30 Blood protein levels; LUSC cis rs1790761 0.692 rs638140 chr11:67333858 G/C cg08355456 chr11:67383691 NA 0.37 6.88 0.35 2.97e-11 Mean corpuscular volume; LUSC cis rs1448094 0.836 rs7484454 chr12:86425576 A/G cg00310523 chr12:86230176 RASSF9 0.36 6.47 0.33 3.4e-10 Major depressive disorder; LUSC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.61 -9.59 -0.46 2.2e-19 Cognitive test performance; LUSC cis rs4664308 0.692 rs13009231 chr2:160964057 G/T cg03641300 chr2:160917029 PLA2R1 -0.62 -10.2 -0.49 1.9e-21 Idiopathic membranous nephropathy; LUSC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg22105103 chr4:187893119 NA 0.72 14.09 0.61 1e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg18512352 chr11:47633146 NA -0.45 -9.03 -0.44 1.44e-17 Subjective well-being; LUSC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.29 -0.41 2.8e-15 Intelligence (multi-trait analysis); LUSC cis rs1044826 0.619 rs6439856 chr3:139134868 A/T cg15131784 chr3:139108705 COPB2 -0.42 -6.95 -0.36 1.89e-11 Obesity-related traits; LUSC cis rs35146811 0.700 rs7788301 chr7:99782753 C/G cg19116668 chr7:99932089 PMS2L1 -0.33 -5.67 -0.3 3.17e-8 Coronary artery disease; LUSC cis rs4664304 0.966 rs7601374 chr2:160754050 T/C cg03641300 chr2:160917029 PLA2R1 -0.4 -6.48 -0.33 3.26e-10 Crohn's disease;Inflammatory bowel disease; LUSC trans rs4843747 0.671 rs74729706 chr16:88104159 C/T cg26811252 chr16:29126840 RRN3P2 0.58 9.29 0.45 2.02e-18 Menopause (age at onset); LUSC cis rs7584330 0.554 rs4420668 chr2:238444793 G/A cg16989719 chr2:238392110 NA -0.41 -5.88 -0.31 1.01e-8 Prostate cancer; LUSC cis rs1348850 0.567 rs1527401 chr2:178522104 C/T cg22681709 chr2:178499509 PDE11A -0.56 -11.25 -0.52 3.95e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12210905 0.688 rs12215386 chr6:27406877 G/T cg08851530 chr6:28072375 NA 0.93 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI; LUSC cis rs17685 0.725 rs7807647 chr7:75628669 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.75 0.39 1.09e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9362426 0.708 rs6907825 chr6:88102822 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.37 6.11 0.32 2.82e-9 Depressive episodes in bipolar disorder; LUSC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.36 5.65 0.3 3.41e-8 Platelet count; LUSC cis rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05901451 chr6:126070800 HEY2 0.76 12.4 0.56 2.57e-29 Endometrial cancer; LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg13531842 chr10:38383804 ZNF37A -0.45 -7.08 -0.36 8.53e-12 Extrinsic epigenetic age acceleration; LUSC cis rs10782582 0.593 rs12129523 chr1:76129223 C/A cg22875332 chr1:76189707 ACADM -0.41 -6.18 -0.32 1.89e-9 Daytime sleep phenotypes; LUSC cis rs2932538 0.922 rs12758377 chr1:113137221 C/A cg22162597 chr1:113214053 CAPZA1 0.7 10.1 0.48 4.1e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.03 0.4 1.66e-14 Axial length; LUSC cis rs6582630 0.638 rs1829584 chr12:38526299 G/T cg13010199 chr12:38710504 ALG10B -0.44 -6.61 -0.34 1.57e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs800082 0.799 rs1949954 chr3:144227977 A/C cg24215973 chr2:240111563 HDAC4 0.4 5.96 0.31 6.41e-9 Smoking behavior; LUSC cis rs9790314 1.000 rs975323 chr3:161021322 A/G cg03342759 chr3:160939853 NMD3 -0.5 -8.39 -0.42 1.43e-15 Morning vs. evening chronotype; LUSC cis rs6496044 0.568 rs1982743 chr15:86068759 A/T cg13263323 chr15:86062960 AKAP13 -0.37 -6.04 -0.31 4.14e-9 Interstitial lung disease; LUSC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.17e-10 Aortic root size; LUSC cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.32 -0.33 8.53e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg07212818 chr11:638076 DRD4 -0.45 -7.46 -0.38 7.78e-13 Systemic lupus erythematosus; LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg16647868 chr5:131706066 SLC22A5 0.4 6.27 0.32 1.13e-9 Breast cancer; LUSC cis rs11792861 0.816 rs28361111 chr9:111761012 A/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.56 -0.34 2.11e-10 Menarche (age at onset); LUSC cis rs6940638 0.688 rs9393791 chr6:27132529 C/G cg12826209 chr6:26865740 GUSBL1 0.52 7.51 0.38 5.31e-13 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg08677398 chr8:58056175 NA 0.58 7.01 0.36 1.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg04267008 chr7:1944627 MAD1L1 -0.56 -8.48 -0.42 7.37e-16 Bipolar disorder and schizophrenia; LUSC cis rs478304 0.934 rs517115 chr11:65526988 C/T cg08755490 chr11:65554678 OVOL1 0.4 5.82 0.3 1.4e-8 Acne (severe); LUSC cis rs925255 0.713 rs9309662 chr2:28629892 A/G cg01273330 chr2:28605224 NA 0.41 6.7 0.34 8.86e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg11764359 chr7:65958608 NA 0.7 11.0 0.52 3.29e-24 Aortic root size; LUSC trans rs7819412 0.838 rs3021494 chr8:10983534 A/G cg15556689 chr8:8085844 FLJ10661 -0.48 -7.13 -0.36 6.36e-12 Triglycerides; LUSC cis rs929354 0.772 rs6459737 chr7:156975136 G/A cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs4343996 0.536 rs10270365 chr7:3417373 C/T cg21248987 chr7:3385318 SDK1 0.35 5.95 0.31 6.88e-9 Motion sickness; LUSC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg07636037 chr3:49044803 WDR6 0.46 6.81 0.35 4.56e-11 Resting heart rate; LUSC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg22496380 chr5:211416 CCDC127 -0.73 -8.78 -0.43 8.85e-17 Breast cancer; LUSC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg06618935 chr21:46677482 NA -0.37 -7.5 -0.38 5.78e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.13 0.55 2.73e-28 Colorectal cancer; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.04 -0.31 4.18e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1008375 0.932 rs9291660 chr4:17663414 A/G cg16339924 chr4:17578868 LAP3 0.63 9.23 0.45 3.22e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC trans rs11098499 0.954 rs10008392 chr4:120318839 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.24 0.32 1.32e-9 Corneal astigmatism; LUSC cis rs9457247 0.602 rs9459854 chr6:167465882 C/T cg06454157 chr6:167490870 NA -0.3 -7.03 -0.36 1.19e-11 Crohn's disease; LUSC cis rs35146811 0.695 rs1727132 chr7:99812297 T/C cg22906224 chr7:99728672 NA -0.47 -6.52 -0.34 2.56e-10 Coronary artery disease; LUSC cis rs6733011 0.508 rs12712041 chr2:99522059 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.93 -0.35 2.15e-11 Bipolar disorder; LUSC cis rs2439831 0.850 rs12441127 chr15:44021175 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.89 8.72 0.43 1.37e-16 Lung cancer in ever smokers; LUSC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg13531842 chr10:38383804 ZNF37A -0.46 -7.19 -0.37 4.37e-12 Extrinsic epigenetic age acceleration; LUSC trans rs61931739 0.649 rs2263218 chr12:33729679 C/G cg26384229 chr12:38710491 ALG10B 0.42 6.07 0.32 3.54e-9 Morning vs. evening chronotype; LUSC cis rs9653442 0.545 rs12987212 chr2:100761156 C/T cg22139774 chr2:100720529 AFF3 -0.42 -7.26 -0.37 2.8e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg03146154 chr1:46216737 IPP 0.58 8.69 0.43 1.69e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7493 0.755 rs13223537 chr7:94966167 C/T cg17330251 chr7:94953956 PON1 0.39 5.93 0.31 7.37e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02149884 chr3:123680462 CCDC14 -0.49 -7.24 -0.37 3.15e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20787340 chr1:59250966 JUN 0.77 6.2 0.32 1.68e-9 Cognitive performance; LUSC trans rs61931739 0.890 rs1705753 chr12:34144594 C/T cg26384229 chr12:38710491 ALG10B 0.58 9.44 0.46 6.47e-19 Morning vs. evening chronotype; LUSC cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg24642439 chr20:33292090 TP53INP2 0.64 9.96 0.48 1.19e-20 Coronary artery disease; LUSC cis rs9420 0.925 rs10896636 chr11:57448032 C/G cg23127183 chr11:57508653 C11orf31 -0.59 -9.02 -0.44 1.53e-17 Schizophrenia; LUSC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3857536 0.605 rs36040831 chr6:66876588 G/A cg07460842 chr6:66804631 NA -0.62 -9.01 -0.44 1.57e-17 Blood trace element (Cu levels); LUSC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11890956 chr21:40555474 PSMG1 1.02 20.38 0.74 1.44e-60 Cognitive function; LUSC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg07414643 chr4:187882934 NA 0.51 8.93 0.44 2.98e-17 Lobe attachment (rater-scored or self-reported); LUSC trans rs2797160 1.000 rs1418639 chr6:125999940 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.59 -0.34 1.71e-10 Endometrial cancer; LUSC cis rs2204008 0.614 rs4578492 chr12:38036350 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.74 0.65 3.8e-42 Bladder cancer; LUSC trans rs72834455 0.858 rs72834468 chr2:119518483 G/A cg02397686 chr17:73851076 WBP2 -0.65 -6.09 -0.32 3.19e-9 Tonsillectomy; LUSC cis rs9837602 0.935 rs9875640 chr3:99729091 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.93 -0.31 7.76e-9 Breast cancer; LUSC cis rs1957429 0.901 rs60979440 chr14:65390231 A/G cg23373153 chr14:65346875 NA -1.04 -11.35 -0.53 1.85e-25 Pediatric areal bone mineral density (radius); LUSC cis rs6582630 0.615 rs10880642 chr12:38554152 A/G cg13010199 chr12:38710504 ALG10B -0.49 -7.33 -0.37 1.74e-12 Drug-induced liver injury (flucloxacillin); LUSC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs9905704 0.709 rs758378 chr17:56607746 G/C cg19466818 chr17:56409534 MIR142 0.31 6.01 0.31 4.75e-9 Testicular germ cell tumor; LUSC cis rs6906287 0.647 rs3734381 chr6:118887303 A/G cg21191810 chr6:118973309 C6orf204 0.34 6.21 0.32 1.54e-9 Electrocardiographic conduction measures; LUSC trans rs28735056 0.904 rs62103174 chr18:77621048 A/G cg05926928 chr17:57297772 GDPD1 0.52 7.36 0.37 1.46e-12 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20062097 chr7:45808644 SEPT13 -0.4 -5.96 -0.31 6.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg06550200 chr5:1325588 CLPTM1L -0.67 -11.82 -0.54 3.73e-27 Lung cancer; LUSC cis rs72717009 0.825 rs7515174 chr1:161476949 C/G cg23840854 chr1:161414152 NA -0.92 -11.2 -0.52 6.13e-25 Rheumatoid arthritis; LUSC cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg05283184 chr6:79620031 NA -0.57 -12.13 -0.55 2.57e-28 Intelligence (multi-trait analysis); LUSC cis rs977987 0.806 rs7188604 chr16:75451170 T/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.64 -0.34 1.27e-10 Dupuytren's disease; LUSC cis rs4499344 0.623 rs11670818 chr19:33099854 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.96 13.55 0.6 1.2e-33 Mean platelet volume; LUSC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.58e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg14844989 chr11:31128820 NA -0.37 -5.79 -0.3 1.67e-8 Red blood cell count; LUSC trans rs1728785 1.000 rs1728781 chr16:68567794 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.49 -6.21 -0.32 1.59e-9 Multiple sclerosis; LUSC trans rs941408 1.000 rs1736180 chr19:2796021 C/T cg22153745 chr1:153894579 GATAD2B -0.55 -8.54 -0.42 4.68e-16 Total cholesterol levels; LUSC cis rs1577917 0.958 rs34622605 chr6:86456519 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.85 -0.44 5.09e-17 Response to antipsychotic treatment; LUSC cis rs9815354 1.000 rs2272006 chr3:41997059 C/T cg03022575 chr3:42003672 ULK4 -0.51 -5.79 -0.3 1.65e-8 Pulse pressure;Diastolic blood pressure; LUSC trans rs79527984 0.742 rs1949395 chr7:71836708 T/A cg12001078 chr4:100790361 DAPP1 0.33 6.1 0.32 2.9e-9 Intelligence (multi-trait analysis); LUSC cis rs981844 0.712 rs4292309 chr4:154745178 C/A cg14289246 chr4:154710475 SFRP2 -0.44 -6.05 -0.31 3.86e-9 Response to statins (LDL cholesterol change); LUSC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg18479299 chr3:125709523 NA -0.51 -5.87 -0.31 1.05e-8 Blood pressure (smoking interaction); LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg01879757 chr17:41196368 BRCA1 -0.47 -7.16 -0.36 5.11e-12 Menopause (age at onset); LUSC cis rs877282 0.898 rs12358513 chr10:757571 A/G cg17470449 chr10:769945 NA 0.52 6.97 0.36 1.72e-11 Uric acid levels; LUSC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg13628971 chr7:2884303 GNA12 0.49 6.93 0.35 2.17e-11 Height; LUSC cis rs2985684 0.894 rs6572586 chr14:50021941 A/C cg04989706 chr14:50066350 PPIL5 -0.46 -6.09 -0.32 3.17e-9 Carotid intima media thickness; LUSC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg08847533 chr14:75593920 NEK9 -0.78 -13.52 -0.59 1.59e-33 Height; LUSC cis rs7524258 0.835 rs7543228 chr1:7306538 G/C cg07173049 chr1:7289937 CAMTA1 0.32 6.55 0.34 2.22e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs1003719 0.591 rs13046303 chr21:38551976 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -9.1 -0.45 8.27e-18 Eye color traits; LUSC cis rs7216064 1.000 rs12602655 chr17:65909442 A/G cg12091567 chr17:66097778 LOC651250 -0.76 -9.6 -0.46 2e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs4631830 0.900 rs7920517 chr10:51532621 G/A cg10326726 chr10:51549505 MSMB -0.37 -6.39 -0.33 5.56e-10 Prostate-specific antigen levels; LUSC cis rs27434 0.583 rs26653 chr5:96139250 C/G cg16492584 chr5:96139282 ERAP1 -0.56 -7.8 -0.39 7.82e-14 Ankylosing spondylitis; LUSC cis rs9427116 0.702 rs9427109 chr1:154609009 A/G cg17218026 chr1:154582156 ADAR 0.56 9.92 0.48 1.69e-20 Blood protein levels; LUSC cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.98 -0.36 1.58e-11 Menopause (age at onset); LUSC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg05738196 chr6:26577821 NA -0.59 -6.85 -0.35 3.53e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg20607798 chr8:58055168 NA 0.51 5.98 0.31 5.58e-9 Developmental language disorder (linguistic errors); LUSC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.3e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9399401 0.710 rs7765770 chr6:142687305 C/T cg04461802 chr6:142623433 GPR126 0.48 5.96 0.31 6.25e-9 Chronic obstructive pulmonary disease; LUSC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg17340268 chr14:105411764 AHNAK2 -0.39 -6.2 -0.32 1.62e-9 Rheumatoid arthritis; LUSC trans rs1325195 0.881 rs2066279 chr1:179172856 T/A cg11624085 chr17:8464688 MYH10 0.41 6.64 0.34 1.29e-10 IgE grass sensitization; LUSC cis rs870825 0.860 rs72703526 chr4:185605676 A/T cg04058563 chr4:185651563 MLF1IP 0.77 10.15 0.49 2.77e-21 Blood protein levels; LUSC cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg07828340 chr4:882639 GAK 1.09 11.58 0.54 2.65e-26 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.909 rs2127821 chr4:120394535 T/C cg25214090 chr10:38739885 LOC399744 0.6 8.84 0.44 5.75e-17 Corneal astigmatism; LUSC cis rs7833787 1.000 rs17468166 chr8:18705047 C/T cg17701159 chr8:18705777 PSD3 -0.39 -6.42 -0.33 4.71e-10 Obesity-related traits; LUSC cis rs380904 0.517 rs11775744 chr8:144649192 A/G cg13399544 chr8:144649678 C8orf73 -0.43 -6.72 -0.35 7.9e-11 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs12711979 0.509 rs13000873 chr2:3823705 T/C cg17052675 chr2:3827356 NA -0.84 -20.22 -0.74 6.49e-60 Itch intensity from mosquito bite adjusted by bite size; LUSC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg03929089 chr4:120376271 NA -0.65 -9.46 -0.46 5.78e-19 Coronary artery disease; LUSC cis rs11051970 0.636 rs188978 chr12:32570627 T/C cg02745156 chr12:32552066 NA 0.4 7.11 0.36 7.3e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2963155 0.518 rs2963151 chr5:142734151 T/C cg17617527 chr5:142782415 NR3C1 0.68 8.42 0.42 1.14e-15 Breast cancer; LUSC cis rs926938 0.584 rs1286561 chr1:115375428 T/C cg12756093 chr1:115239321 AMPD1 -0.53 -7.97 -0.4 2.59e-14 Autism; LUSC cis rs7584330 1.000 rs7584330 chr2:238387228 A/G cg16989719 chr2:238392110 NA -0.42 -7.23 -0.37 3.27e-12 Prostate cancer; LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg18404041 chr3:52824283 ITIH1 -0.62 -11.94 -0.55 1.32e-27 Bipolar disorder; LUSC trans rs35110281 0.837 rs2838340 chr21:45076373 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.7 0.47 8.99e-20 Mean corpuscular volume; LUSC cis rs983392 0.709 rs11826180 chr11:59991333 T/C cg24026212 chr11:59952134 MS4A6A -0.35 -6.08 -0.32 3.22e-9 Alzheimer's disease (late onset); LUSC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg04944784 chr2:26401820 FAM59B -0.67 -9.58 -0.46 2.38e-19 Gut microbiome composition (summer); LUSC cis rs240993 0.595 rs4947127 chr6:111902798 T/G cg22127309 chr6:111907043 TRAF3IP2 0.34 6.12 0.32 2.69e-9 Inflammatory skin disease;Psoriasis; LUSC cis rs208520 1.000 rs12199876 chr6:66989469 A/G cg07460842 chr6:66804631 NA 0.92 12.04 0.55 5.76e-28 Exhaled nitric oxide output; LUSC cis rs11098499 0.865 rs28634456 chr4:120375778 A/G cg09307838 chr4:120376055 NA 0.77 10.81 0.51 1.49e-23 Corneal astigmatism; LUSC cis rs7833986 0.534 rs17813240 chr8:56925791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.7 11.07 0.52 1.84e-24 Height; LUSC cis rs7267979 0.903 rs2474769 chr20:25248725 C/T cg08601574 chr20:25228251 PYGB 0.49 7.55 0.38 4.12e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg26061582 chr7:22766209 IL6 0.52 7.48 0.38 6.8e-13 Lung cancer; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg06877462 chr1:205807181 PM20D1 0.53 10.13 0.48 3.36e-21 Menarche (age at onset); LUSC trans rs9987353 0.830 rs4841117 chr8:9130132 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.21 -0.32 1.61e-9 Recombination measurement; LUSC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg06494592 chr3:125709126 NA -0.53 -5.92 -0.31 8.19e-9 Blood pressure (smoking interaction); LUSC trans rs1941687 0.831 rs12957087 chr18:31328519 C/T cg27147174 chr7:100797783 AP1S1 -0.46 -6.82 -0.35 4.38e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg27129171 chr3:47204927 SETD2 0.56 8.99 0.44 1.91e-17 Colorectal cancer; LUSC cis rs3126085 0.935 rs10888471 chr1:152200849 G/T cg26876637 chr1:152193138 HRNR -0.45 -6.34 -0.33 7.32e-10 Atopic dermatitis; LUSC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg17971929 chr21:40555470 PSMG1 0.79 13.99 0.61 2.56e-35 Cognitive function; LUSC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg12560992 chr17:57184187 TRIM37 0.85 15.41 0.64 7.59e-41 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 1.93e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs11053218 chr12:34474792 A/C cg26384229 chr12:38710491 ALG10B -0.86 -14.5 -0.62 2.66e-37 Morning vs. evening chronotype; LUSC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 7.58 0.38 3.4e-13 Reticulocyte count; LUSC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.18 -0.72 8.14e-56 Height; LUSC cis rs9300255 0.602 rs1727315 chr12:123638930 A/G cg00376283 chr12:123451042 ABCB9 -0.66 -8.36 -0.42 1.74e-15 Neutrophil percentage of white cells; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00557709 chr1:82268801 LPHN2 -0.44 -6.34 -0.33 7.51e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg21138405 chr5:131827807 IRF1 0.56 10.98 0.52 3.71e-24 Asthma (sex interaction); LUSC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg03264133 chr6:25882463 NA -0.47 -7.99 -0.4 2.25e-14 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.65 -0.34 1.21e-10 Lung cancer; LUSC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg23711669 chr6:146136114 FBXO30 0.88 16.44 0.67 6.52e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs2455601 0.638 rs3815991 chr11:9007669 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.45 6.45 0.33 3.83e-10 Schizophrenia; LUSC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.87 -0.35 3.15e-11 Aortic root size; LUSC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg18357526 chr6:26021779 HIST1H4A 0.4 6.22 0.32 1.47e-9 Intelligence (multi-trait analysis); LUSC cis rs6815814 0.861 rs10034903 chr4:38784678 C/G cg06935464 chr4:38784597 TLR10 0.46 5.94 0.31 7.29e-9 Breast cancer; LUSC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg13902645 chr11:5959945 NA -0.63 -10.31 -0.49 8.35e-22 DNA methylation (variation); LUSC cis rs17014483 1.000 rs3017903 chr4:89657776 A/C cg01026744 chr4:89619053 NAP1L5;HERC3 0.68 5.76 0.3 1.93e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg06640241 chr16:89574553 SPG7 0.75 12.27 0.56 7.99e-29 Multiple myeloma (IgH translocation); LUSC cis rs295140 0.605 rs3739119 chr2:201194279 C/A cg04283868 chr2:201171347 SPATS2L 0.41 6.03 0.31 4.41e-9 QT interval; LUSC cis rs7819412 0.521 rs9329238 chr8:11033737 C/T cg21775007 chr8:11205619 TDH -0.47 -6.35 -0.33 7.06e-10 Triglycerides; LUSC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.44 6.45 0.33 3.97e-10 Schizophrenia; LUSC cis rs116139393 0.540 rs12539942 chr7:6776585 C/T cg09896999 chr7:6746977 ZNF12 -0.47 -6.86 -0.35 3.43e-11 Alzheimer's disease (APOE e4 interaction); LUSC trans rs11148252 0.669 rs4884320 chr13:53006914 T/C cg18335740 chr13:41363409 SLC25A15 0.6 8.87 0.44 4.43e-17 Lewy body disease; LUSC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg00945038 chr17:61921165 SMARCD2 0.37 5.66 0.3 3.21e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg20243544 chr17:37824526 PNMT 0.46 5.66 0.3 3.19e-8 Glomerular filtration rate (creatinine); LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs9914988 0.943 rs2242345 chr17:27185827 C/T cg19789473 chr17:27170043 C17orf63 0.3 5.72 0.3 2.39e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7651511 0.674 rs11916906 chr3:141314133 A/T cg00789793 chr3:141329863 RASA2 0.38 5.74 0.3 2.1e-8 Mean corpuscular hemoglobin; LUSC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg16506815 chr2:162101123 NA 0.42 6.28 0.32 1.06e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs8017423 0.967 rs6575117 chr14:90715412 G/A cg04374321 chr14:90722782 PSMC1 0.76 12.11 0.55 3.19e-28 Mortality in heart failure; LUSC cis rs9560113 1.000 rs4773387 chr13:112180955 T/C cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.6e-13 Menarche (age at onset); LUSC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg07343612 chr16:622815 PIGQ -0.77 -13.11 -0.58 5.63e-32 Height; LUSC cis rs34779708 0.766 rs7913451 chr10:35551525 T/C cg03585969 chr10:35415529 CREM 0.51 6.99 0.36 1.54e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9926296 0.632 rs4785716 chr16:89801127 T/C cg04287289 chr16:89883240 FANCA 0.51 7.71 0.39 1.5e-13 Vitiligo; LUSC trans rs2243480 1.000 rs4718315 chr7:65648541 T/C cg10756647 chr7:56101905 PSPH -0.84 -8.42 -0.42 1.14e-15 Diabetic kidney disease; LUSC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg06221963 chr1:154839813 KCNN3 -0.63 -14.45 -0.62 4.29e-37 Prostate cancer; LUSC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 8.52 0.42 5.43e-16 Schizophrenia; LUSC trans rs61931739 0.926 rs13377754 chr12:34051765 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.85 -0.39 5.57e-14 Morning vs. evening chronotype; LUSC cis rs3829109 0.534 rs563 chr9:139296485 C/T cg14019695 chr9:139328340 INPP5E -0.37 -5.86 -0.31 1.11e-8 Peak insulin response;Acute insulin response; LUSC cis rs477692 1.000 rs569235 chr10:131411620 T/C cg11019008 chr10:131425282 MGMT 0.45 6.8 0.35 4.85e-11 Response to temozolomide; LUSC cis rs9419702 0.526 rs9419637 chr10:133548059 T/C cg04492858 chr10:133558786 NA 0.38 6.29 0.33 9.82e-10 Survival in rectal cancer; LUSC cis rs7605827 0.930 rs6710456 chr2:15669939 C/T cg19274914 chr2:15703543 NA -0.45 -8.57 -0.42 3.82e-16 Educational attainment (years of education); LUSC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg06008330 chr7:65541103 ASL -0.36 -5.71 -0.3 2.54e-8 Aortic root size; LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg24675658 chr1:53192096 ZYG11B -0.6 -9.92 -0.48 1.75e-20 Monocyte count; LUSC cis rs6487679 1.000 rs10734765 chr12:9369385 G/A cg00504896 chr12:9437009 LOC642846 -0.44 -5.77 -0.3 1.85e-8 Non-alcoholic fatty liver disease histology (AST); LUSC cis rs6964587 0.869 rs11769726 chr7:91485231 A/G cg17063962 chr7:91808500 NA -0.51 -7.8 -0.39 7.79e-14 Breast cancer; LUSC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.28e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs193541 0.617 rs2045628 chr5:122095154 C/T cg19077854 chr5:122220652 SNX24 0.39 7.91 0.4 3.85e-14 Glucose homeostasis traits; LUSC cis rs1997103 0.954 rs4947505 chr7:55409448 T/C cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs778371 0.522 rs6704768 chr2:233592501 C/T cg08000102 chr2:233561755 GIGYF2 0.72 12.67 0.57 2.71e-30 Schizophrenia; LUSC trans rs61931739 0.534 rs1490113 chr12:34132394 A/G cg13010199 chr12:38710504 ALG10B 0.56 8.57 0.42 3.99e-16 Morning vs. evening chronotype; LUSC cis rs926938 0.527 rs360678 chr1:115493902 T/A cg12756093 chr1:115239321 AMPD1 0.46 7.01 0.36 1.33e-11 Autism; LUSC cis rs12594515 1.000 rs6493169 chr15:45986994 A/G cg19682013 chr15:45996608 NA -0.4 -6.1 -0.32 2.95e-9 Waist circumference;Weight; LUSC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg00684032 chr4:1343700 KIAA1530 0.45 7.95 0.4 2.82e-14 Obesity-related traits; LUSC cis rs9378357 0.702 rs4385351 chr6:3280591 A/C cg08754725 chr6:3293098 SLC22A23 0.52 5.79 0.3 1.66e-8 Obesity-related traits; LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg27170947 chr2:26402098 FAM59B -0.7 -10.69 -0.5 3.92e-23 Gut microbiome composition (summer); LUSC cis rs1030877 0.889 rs2576746 chr2:105909559 G/A cg02079111 chr2:105885981 TGFBRAP1 0.76 14.85 0.63 1.13e-38 Obesity-related traits; LUSC cis rs73206853 0.841 rs73206894 chr12:110876328 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg18479299 chr3:125709523 NA -0.51 -5.77 -0.3 1.76e-8 Blood pressure (smoking interaction); LUSC cis rs1358748 0.555 rs2815340 chr1:67533623 G/C cg02640540 chr1:67518911 SLC35D1 0.66 6.69 0.34 9.24e-11 Tuberculosis; LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg08088566 chr11:430123 ANO9 0.6 6.76 0.35 6.23e-11 Body mass index; LUSC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.67 10.78 0.51 1.95e-23 Body mass index (adult); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg14310890 chr6:108881016 FOXO3 0.52 6.38 0.33 5.85e-10 Cognitive function;Information processing speed; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg11494091 chr17:61959527 GH2 0.61 12.44 0.56 1.96e-29 Prudent dietary pattern; LUSC cis rs11031096 0.711 rs61899755 chr11:4201317 G/T cg18678763 chr11:4115507 RRM1 -0.41 -5.77 -0.3 1.85e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.43 -0.33 4.4e-10 Electroencephalogram traits; LUSC cis rs6785206 0.772 rs2811493 chr3:128357299 C/G cg16766828 chr3:128327626 NA -0.71 -7.69 -0.39 1.68e-13 Lymphocyte percentage of white cells; LUSC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg12386194 chr3:101231763 SENP7 -0.64 -8.59 -0.43 3.46e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs10416265 0.528 rs10420258 chr19:33602757 C/T cg17764715 chr19:33622953 WDR88 0.54 5.86 0.31 1.09e-8 Bone properties (heel); LUSC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg21951975 chr1:209979733 IRF6 0.54 7.86 0.39 5.45e-14 Cleft lip with or without cleft palate; LUSC cis rs7582720 0.836 rs72938315 chr2:204121063 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.76 8.04 0.4 1.62e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -5.91 -0.31 8.47e-9 Developmental language disorder (linguistic errors); LUSC cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg23158103 chr7:148848205 ZNF398 -0.46 -7.62 -0.38 2.72e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7246657 0.765 rs10402455 chr19:37728707 G/A cg23950597 chr19:37808831 NA -0.64 -6.97 -0.36 1.65e-11 Coronary artery calcification; LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg22907277 chr7:1156413 C7orf50 0.72 7.57 0.38 3.61e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg11050988 chr7:1952600 MAD1L1 -0.32 -6.04 -0.31 4.14e-9 Bipolar disorder and schizophrenia; LUSC trans rs72674100 0.881 rs10016957 chr4:97989074 T/C cg16405019 chr1:18959625 PAX7 -0.61 -6.44 -0.33 4.04e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6500602 0.727 rs55939215 chr16:4541390 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 6.47 0.33 3.56e-10 Schizophrenia; LUSC cis rs9768139 0.708 rs896779 chr7:158113390 T/G cg25566285 chr7:158114605 PTPRN2 0.36 6.69 0.34 9.34e-11 Calcium levels; LUSC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.82 -0.35 4.29e-11 Total body bone mineral density; LUSC cis rs477692 0.905 rs576560 chr10:131420697 C/A cg05714579 chr10:131428358 MGMT 0.52 7.9 0.4 4e-14 Response to temozolomide; LUSC cis rs11785400 0.793 rs10956992 chr8:143736235 A/C cg24634471 chr8:143751801 JRK 0.51 7.34 0.37 1.59e-12 Schizophrenia; LUSC cis rs909341 0.710 rs6089953 chr20:62291008 C/T cg09650180 chr20:62225654 GMEB2 -0.46 -5.97 -0.31 6.1e-9 Atopic dermatitis; LUSC cis rs9325144 0.534 rs6582538 chr12:38629997 A/C cg26384229 chr12:38710491 ALG10B -0.67 -10.45 -0.5 2.64e-22 Morning vs. evening chronotype; LUSC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg22875332 chr1:76189707 ACADM 0.82 13.83 0.6 1.02e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11039100 0.920 rs11038963 chr11:5781361 A/G cg13902645 chr11:5959945 NA -0.55 -6.06 -0.31 3.7e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs8064299 0.560 rs11077763 chr17:72786029 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.93 19.36 0.73 1.53e-56 Monocyte count; LUSC cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg08999081 chr20:33150536 PIGU 0.45 8.29 0.41 2.78e-15 Coronary artery disease; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg07507251 chr3:52567010 NT5DC2 0.35 6.94 0.35 2.1e-11 Bipolar disorder; LUSC cis rs2073300 1.000 rs112057098 chr20:23448901 C/T cg09953122 chr20:23471693 CST8 -0.72 -6.6 -0.34 1.62e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg23283495 chr1:209979779 IRF6 0.63 9.24 0.45 3e-18 Cleft lip with or without cleft palate; LUSC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg24904631 chr17:17875305 TOM1L2;LRRC48 0.37 5.85 0.3 1.16e-8 Total body bone mineral density; LUSC cis rs7215564 0.908 rs55886624 chr17:78658657 G/A cg09596252 chr17:78655493 RPTOR 0.55 6.04 0.31 4.18e-9 Myopia (pathological); LUSC cis rs8141797 0.685 rs732811 chr22:24587818 T/C cg00411358 chr22:24577142 SUSD2 -0.58 -6.1 -0.32 3.02e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg00814883 chr7:100076585 TSC22D4 -0.69 -9.17 -0.45 5.08e-18 Platelet count; LUSC cis rs2179367 0.600 rs58747890 chr6:149780505 G/A cg07828024 chr6:149772892 ZC3H12D -0.37 -6.13 -0.32 2.53e-9 Dupuytren's disease; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg24542852 chr12:569111 B4GALNT3 0.42 6.04 0.31 4.22e-9 Mosquito bite size; LUSC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg10253484 chr15:75165896 SCAMP2 -0.43 -6.09 -0.32 3.17e-9 Caffeine consumption; LUSC cis rs243505 1.000 rs1019059 chr7:148424247 A/G cg09806900 chr7:148480153 CUL1 -0.48 -6.84 -0.35 3.81e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9300255 0.508 rs1716176 chr12:123655467 T/G cg00376283 chr12:123451042 ABCB9 0.65 8.22 0.41 4.63e-15 Neutrophil percentage of white cells; LUSC cis rs11122272 0.735 rs2749699 chr1:231520279 A/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg07936489 chr17:37558343 FBXL20 0.7 9.69 0.47 1.02e-19 Glomerular filtration rate (creatinine); LUSC cis rs2576037 0.521 rs4986227 chr18:44595031 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.28 0.33 1.03e-9 Personality dimensions; LUSC cis rs9517320 0.967 rs7997785 chr13:99127985 T/A cg20487152 chr13:99095054 FARP1 0.35 6.44 0.33 4.08e-10 Longevity; LUSC cis rs4423214 0.840 rs1790328 chr11:71148038 G/A cg05163923 chr11:71159392 DHCR7 -0.7 -9.2 -0.45 4.07e-18 Vitamin D levels; LUSC cis rs4253772 0.872 rs11704508 chr22:46638540 A/G cg18190219 chr22:46762943 CELSR1 -0.52 -6.02 -0.31 4.71e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs8062405 0.964 rs7193733 chr16:28875482 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9314323 0.767 rs7012604 chr8:26204089 G/A cg11498726 chr8:26250323 BNIP3L -0.42 -5.88 -0.31 1.02e-8 Red cell distribution width; LUSC cis rs12188164 0.502 rs55929184 chr5:405576 G/A cg26850624 chr5:429559 AHRR -0.37 -7.03 -0.36 1.19e-11 Cystic fibrosis severity; LUSC cis rs6456156 0.586 rs6456149 chr6:167463902 T/C cg07741184 chr6:167504864 NA 0.38 6.76 0.35 6.07e-11 Primary biliary cholangitis; LUSC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg17252645 chr8:143867129 LY6D -0.53 -10.25 -0.49 1.3e-21 Urinary tract infection frequency; LUSC cis rs10504229 0.871 rs10504226 chr8:58159283 A/G cg21724239 chr8:58056113 NA 0.59 7.2 0.37 3.98e-12 Developmental language disorder (linguistic errors); LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.03 -0.31 4.31e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7267979 1.000 rs884613 chr20:25288505 C/T cg03522245 chr20:25566470 NINL -0.36 -5.83 -0.3 1.33e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg17764715 chr19:33622953 WDR88 -0.6 -8.66 -0.43 2.11e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs950169 0.922 rs67804993 chr15:85104030 T/G cg11189052 chr15:85197271 WDR73 0.47 5.76 0.3 1.94e-8 Schizophrenia; LUSC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg18240062 chr17:79603768 NPLOC4 -0.78 -15.34 -0.64 1.45e-40 Eye color traits; LUSC cis rs11648785 0.590 rs4324129 chr16:90099061 C/T cg16611967 chr16:90144006 NA 0.4 5.69 0.3 2.82e-8 Tanning; LUSC cis rs12210905 0.688 rs72843191 chr6:27383301 G/C cg08851530 chr6:28072375 NA 0.95 5.85 0.3 1.2e-8 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg08677398 chr8:58056175 NA 0.52 6.29 0.33 9.86e-10 Developmental language disorder (linguistic errors); LUSC cis rs4954585 0.683 rs10221893 chr2:137013606 C/T cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.79e-13 Colorectal cancer; LUSC cis rs4363385 0.597 rs6679201 chr1:152976840 C/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.82 -0.39 6.89e-14 Inflammatory skin disease; LUSC cis rs9300255 0.510 rs1727322 chr12:123699520 A/G cg00376283 chr12:123451042 ABCB9 0.7 7.93 0.4 3.22e-14 Neutrophil percentage of white cells; LUSC cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.38 -6.74 -0.35 6.84e-11 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.855 rs10891285 chr11:111527775 T/C cg09085632 chr11:111637200 PPP2R1B -1.09 -17.73 -0.7 4.82e-50 Primary sclerosing cholangitis; LUSC cis rs7580658 0.864 rs1566823 chr2:128018192 A/G cg09760422 chr2:128146352 NA -0.28 -5.89 -0.31 9.32e-9 Protein C levels; LUSC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg11663144 chr21:46675770 NA -0.41 -7.22 -0.37 3.46e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9359856 0.517 rs11962350 chr6:90592406 G/A cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.37 -0.42 1.58e-15 Bipolar disorder; LUSC trans rs61931739 0.929 rs2389274 chr12:34075149 T/C cg26384229 chr12:38710491 ALG10B -0.59 -9.57 -0.46 2.41e-19 Morning vs. evening chronotype; LUSC cis rs7520050 0.902 rs7514192 chr1:46248977 A/G cg24296786 chr1:45957014 TESK2 0.42 5.88 0.31 9.75e-9 Red blood cell count;Reticulocyte count; LUSC cis rs1018836 0.544 rs2339154 chr8:91459316 T/C cg16814680 chr8:91681699 NA -0.48 -6.91 -0.35 2.51e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2204008 0.837 rs11168504 chr12:37964922 G/T cg26384229 chr12:38710491 ALG10B 0.93 15.77 0.65 2.91e-42 Bladder cancer; LUSC cis rs9517302 0.847 rs9517300 chr13:99095057 T/C cg22223119 chr13:99095684 FARP1 -0.77 -11.92 -0.55 1.51e-27 Obesity-related traits; LUSC cis rs2302729 0.625 rs10848693 chr12:2833013 A/T cg19945202 chr12:2788847 CACNA1C 0.39 5.66 0.3 3.28e-8 Sleep quality; LUSC cis rs2273669 0.504 rs77608624 chr6:109442854 A/G cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC cis rs427394 0.659 rs274675 chr5:6755319 C/T cg10857441 chr5:6722123 POLS -0.45 -8.05 -0.4 1.51e-14 Menopause (age at onset); LUSC trans rs13300663 0.626 rs7865442 chr9:4772328 C/G cg09381805 chr19:42932508 LIPE 0.42 5.94 0.31 7.04e-9 Platelet count; LUSC cis rs25645 0.502 rs7223318 chr17:38108553 G/C cg17467752 chr17:38218738 THRA 0.41 5.69 0.3 2.73e-8 Myeloid white cell count; LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg23758822 chr17:41437982 NA 1.05 20.2 0.74 7.77e-60 Menopause (age at onset); LUSC cis rs28374715 0.532 rs11854820 chr15:41676526 G/A cg18705301 chr15:41695430 NDUFAF1 -1.05 -22.83 -0.78 3.76e-70 Ulcerative colitis; LUSC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.39 6.17 0.32 1.93e-9 Intelligence (multi-trait analysis); LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.68 10.39 0.49 4.38e-22 Lymphocyte counts; LUSC cis rs8030485 0.756 rs1521624 chr15:79412399 C/A cg17916960 chr15:79447300 NA 0.35 6.43 0.33 4.41e-10 Left ventricle wall thickness; LUSC cis rs1355223 0.583 rs2941060 chr11:34879154 G/A cg24088639 chr11:34937564 PDHX;APIP -0.47 -6.9 -0.35 2.66e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6076065 0.707 rs1419007 chr20:23336895 T/C cg11657817 chr20:23433608 CST11 0.55 11.08 0.52 1.7e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg16797656 chr11:68205561 LRP5 -0.42 -7.81 -0.39 7.67e-14 Total body bone mineral density; LUSC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 6.16 0.32 2.14e-9 Tonsillectomy; LUSC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg17385448 chr1:15911702 AGMAT 0.36 6.12 0.32 2.57e-9 Systolic blood pressure; LUSC cis rs2224391 0.628 rs2753245 chr6:5258092 G/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.49 -6.03 -0.31 4.42e-9 Height; LUSC cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg19230755 chr7:65878503 NA 0.44 5.87 0.31 1.03e-8 Aortic root size; LUSC cis rs9733 0.650 rs11204668 chr1:150543686 G/A cg09365446 chr1:150670422 GOLPH3L -0.44 -6.37 -0.33 6.43e-10 Tonsillectomy; LUSC trans rs208520 0.586 rs208442 chr6:66900618 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.8 -11.46 -0.53 7.4e-26 Exhaled nitric oxide output; LUSC cis rs7712401 0.601 rs442427 chr5:122322265 T/C cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 14.42 0.62 5.36e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11822910 0.871 rs2581928 chr11:57202790 A/G cg00522883 chr11:57194120 SLC43A3 -0.42 -6.47 -0.33 3.52e-10 Platelet distribution width; LUSC cis rs4654899 0.833 rs10127757 chr1:21490045 A/G cg01072550 chr1:21505969 NA -0.53 -7.9 -0.4 4.08e-14 Superior frontal gyrus grey matter volume; LUSC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg17143192 chr8:8559678 CLDN23 0.39 5.81 0.3 1.46e-8 Mood instability; LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg11062466 chr8:58055876 NA 0.75 9.1 0.45 8.12e-18 Developmental language disorder (linguistic errors); LUSC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg18404041 chr3:52824283 ITIH1 -0.56 -10.62 -0.5 6.62e-23 Bipolar disorder; LUSC cis rs2439831 0.681 rs825740 chr15:43592408 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.07 15.33 0.64 1.55e-40 Lung cancer in ever smokers; LUSC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg04287289 chr16:89883240 FANCA 0.79 13.78 0.6 1.64e-34 Vitiligo; LUSC trans rs72674100 1.000 rs1987173 chr4:97973574 G/C cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs62400317 0.859 rs17209741 chr6:45292438 A/T cg20913747 chr6:44695427 NA -0.45 -7.36 -0.37 1.48e-12 Total body bone mineral density; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05141026 chr8:145064874 GRINA -0.49 -6.66 -0.34 1.16e-10 Hepatitis; LUSC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg05861140 chr6:150128134 PCMT1 -0.4 -6.31 -0.33 9.11e-10 Lung cancer; LUSC trans rs7556950 0.572 rs7566733 chr2:41942989 C/T cg13792581 chr20:43590115 TOMM34 -0.82 -6.62 -0.34 1.46e-10 Major depression and alcohol dependence; LUSC trans rs877282 0.898 rs11253349 chr10:765897 C/G cg22713356 chr15:30763199 NA 1.07 14.17 0.61 5.24e-36 Uric acid levels; LUSC cis rs710216 0.797 rs841854 chr1:43400485 C/T cg22176566 chr1:43424700 SLC2A1 0.49 6.02 0.31 4.67e-9 Red cell distribution width; LUSC cis rs7100689 0.577 rs2236569 chr10:82043576 G/A cg01528321 chr10:82214614 TSPAN14 0.95 14.55 0.62 1.68e-37 Post bronchodilator FEV1; LUSC cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.35e-30 Motion sickness; LUSC cis rs9486719 1.000 rs11757063 chr6:96884886 C/T cg06623918 chr6:96969491 KIAA0776 -0.79 -9.74 -0.47 6.68e-20 Migraine;Coronary artery disease; LUSC cis rs2180341 0.814 rs6919277 chr6:127738050 T/C cg27446573 chr6:127587934 RNF146 0.72 10.98 0.51 3.87e-24 Breast cancer; LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg10360139 chr7:1886902 MAD1L1 -0.44 -6.82 -0.35 4.21e-11 Bipolar disorder and schizophrenia; LUSC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.78e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6977660 0.714 rs10232870 chr7:19818040 A/G cg07541023 chr7:19748670 TWISTNB 0.6 6.51 0.34 2.7e-10 Thyroid stimulating hormone; LUSC cis rs12541635 0.934 rs57715289 chr8:106967124 A/T cg10147462 chr8:107024639 NA 0.55 9.54 0.46 3.08e-19 Age of smoking initiation; LUSC cis rs17818399 0.502 rs1451152 chr2:46800150 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.53 -7.81 -0.39 7.46e-14 Height; LUSC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg03517284 chr6:25882590 NA -0.45 -7.68 -0.39 1.83e-13 Intelligence (multi-trait analysis); LUSC cis rs4604732 0.588 rs6677477 chr1:247629411 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.78 0.35 5.42e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs13315871 0.929 rs76226186 chr3:58318499 C/T cg12435725 chr3:58293450 RPP14 -0.74 -7.16 -0.36 5.15e-12 Cholesterol, total; LUSC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg24562669 chr7:97807699 LMTK2 0.33 5.75 0.3 1.99e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs8072100 0.666 rs6503804 chr17:45772447 G/A cg19784903 chr17:45786737 TBKBP1 -0.42 -6.04 -0.31 4.05e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1595825 0.732 rs4589750 chr2:198426003 C/T cg00982548 chr2:198649783 BOLL -0.51 -6.2 -0.32 1.69e-9 Ulcerative colitis; LUSC cis rs6430585 0.528 rs12464050 chr2:136663110 G/T cg07169764 chr2:136633963 MCM6 1.17 17.75 0.7 4.18e-50 Corneal structure; LUSC cis rs929596 0.606 rs10178992 chr2:234657877 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.62 -10.37 -0.49 4.97e-22 Total bilirubin levels in HIV-1 infection; LUSC cis rs4343996 0.967 rs34735349 chr7:3344115 C/G cg21248987 chr7:3385318 SDK1 0.4 6.88 0.35 3.04e-11 Motion sickness; LUSC cis rs7705502 0.962 rs56245789 chr5:173365310 T/C cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.3e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs897984 0.721 rs2305884 chr16:30970741 G/A cg02466173 chr16:30829666 NA 0.56 11.1 0.52 1.39e-24 Dementia with Lewy bodies; LUSC cis rs9399401 1.000 rs9399401 chr6:142668901 T/C cg03128060 chr6:142623767 GPR126 0.32 5.9 0.31 8.7e-9 Chronic obstructive pulmonary disease; LUSC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg03233332 chr7:66118400 NA -0.42 -6.08 -0.32 3.3e-9 Aortic root size; LUSC cis rs886126 0.684 rs3858704 chr12:111705893 A/G cg10833066 chr12:111807467 FAM109A 0.49 8.41 0.42 1.21e-15 Coronary heart disease; LUSC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg23283495 chr1:209979779 IRF6 0.64 7.61 0.38 2.91e-13 Coronary artery disease; LUSC trans rs4729127 1.000 rs60238694 chr7:94008118 C/T cg14660007 chr13:78271894 SLAIN1 0.5 6.45 0.33 3.88e-10 Intelligence; LUSC cis rs5769707 0.935 rs739239 chr22:50050468 G/A cg05373962 chr22:49881684 NA -0.44 -10.6 -0.5 7.78e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6489882 0.867 rs6489867 chr12:113363550 C/T cg20102336 chr12:113376681 OAS3 -0.43 -6.21 -0.32 1.62e-9 Chronic lymphocytic leukemia; LUSC cis rs9486719 1.000 rs12205728 chr6:96891838 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs2832191 0.967 rs2251377 chr21:30530599 T/C cg24692254 chr21:30365293 RNF160 0.78 13.63 0.6 6.17e-34 Dental caries; LUSC cis rs9314323 1.000 rs9314323 chr8:26243136 A/G cg11498726 chr8:26250323 BNIP3L -0.47 -6.94 -0.35 2.06e-11 Red cell distribution width; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg06873352 chr17:61820015 STRADA 0.72 12.98 0.58 1.83e-31 Prudent dietary pattern; LUSC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg02423579 chr7:2872169 GNA12 -0.48 -7.14 -0.36 6e-12 Height; LUSC cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg17063962 chr7:91808500 NA 0.59 9.36 0.46 1.22e-18 Breast cancer; LUSC cis rs2439831 0.867 rs2251844 chr15:43836478 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.71 0.39 1.41e-13 Lung cancer in ever smokers; LUSC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.53 9.12 0.45 7.4e-18 Menopause (age at onset); LUSC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.37 -0.42 1.6e-15 Height; LUSC cis rs80282103 0.764 rs10047382 chr10:1102868 T/C cg08668510 chr10:1095578 IDI1 0.67 5.91 0.31 8.35e-9 Glomerular filtration rate (creatinine); LUSC cis rs7072216 0.881 rs10883084 chr10:100151189 T/C cg26618903 chr10:100175079 PYROXD2 -0.29 -5.64 -0.3 3.57e-8 Metabolite levels; LUSC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7520050 0.966 rs1707336 chr1:46493460 T/G cg06784218 chr1:46089804 CCDC17 -0.29 -5.64 -0.3 3.56e-8 Red blood cell count;Reticulocyte count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20069020 chr7:108166782 PNPLA8 -0.45 -6.74 -0.35 6.97e-11 Electrocardiographic conduction measures; LUSC cis rs12959570 1 rs12959570 chr18:54333584 G/A cg00152799 chr18:54306261 TXNL1 0.36 5.89 0.31 9.43e-9 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs713587 0.719 rs4665736 chr2:25187599 C/T cg01884057 chr2:25150051 NA -0.38 -8.57 -0.42 4.02e-16 Body mass index in non-asthmatics; LUSC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.28 0.32 1.08e-9 Height; LUSC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg00376283 chr12:123451042 ABCB9 0.68 8.54 0.42 4.8e-16 Neutrophil percentage of white cells; LUSC cis rs1395 0.778 rs6709602 chr2:27405497 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.2 0.37 4.12e-12 Blood metabolite levels; LUSC cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg07606381 chr6:8435919 SLC35B3 -0.72 -12.08 -0.55 4.14e-28 Motion sickness; LUSC cis rs7267979 0.966 rs2257233 chr20:25265984 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -19.94 -0.74 8.05e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -5.87 -0.31 1.02e-8 Total body bone mineral density; LUSC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11644478 chr21:40555479 PSMG1 0.95 19.19 0.72 7.57e-56 Cognitive function; LUSC cis rs7615316 0.934 rs6782400 chr3:142295368 C/A cg16271453 chr3:142027066 XRN1 -0.36 -6.19 -0.32 1.8e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6722750 0.846 rs34923691 chr2:64395183 C/T cg22352474 chr2:64371530 PELI1 0.65 10.33 0.49 6.92e-22 Neuroticism; LUSC cis rs9393777 0.623 rs9348719 chr6:26470032 T/C cg12826209 chr6:26865740 GUSBL1 0.67 7.49 0.38 6.06e-13 Intelligence (multi-trait analysis); LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg13397359 chr6:42928475 GNMT 0.58 9.53 0.46 3.4e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs66887589 0.660 rs4833613 chr4:120150156 A/C cg24375607 chr4:120327624 NA -0.52 -8.16 -0.41 6.8e-15 Diastolic blood pressure; LUSC cis rs7605827 0.930 rs6719652 chr2:15571679 T/G cg19274914 chr2:15703543 NA 0.46 8.61 0.43 2.84e-16 Educational attainment (years of education); LUSC cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg20848291 chr7:100343083 ZAN -0.68 -9.4 -0.46 9.08e-19 Other erythrocyte phenotypes; LUSC cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg09184832 chr6:79620586 NA -0.44 -7.24 -0.37 3.16e-12 Intelligence (multi-trait analysis); LUSC cis rs708547 0.647 rs12621 chr4:57897570 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.74 -0.3 2.08e-8 Response to bleomycin (chromatid breaks); LUSC trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg03929089 chr4:120376271 NA -0.84 -11.51 -0.53 4.83e-26 Coronary artery disease; LUSC cis rs4072705 1.000 rs4836991 chr9:127512040 A/G cg13476313 chr9:127244764 NR5A1 -0.31 -5.99 -0.31 5.42e-9 Menarche (age at onset); LUSC cis rs9309473 1.000 rs6755217 chr2:73641285 C/T cg20560298 chr2:73613845 ALMS1 -0.49 -7.12 -0.36 6.54e-12 Metabolite levels; LUSC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg10356904 chr22:49881777 NA -0.32 -7.3 -0.37 2.15e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg05347473 chr6:146136440 FBXO30 0.43 7.47 0.38 6.89e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15820397 chr19:17622945 PGLS 0.44 6.36 0.33 6.63e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2700987 0.545 rs2700984 chr7:37391820 C/T cg26076750 chr5:98105150 RGMB 0.34 6.06 0.31 3.65e-9 Psoriasis vulgaris;Psoriasis; LUSC cis rs12681287 0.609 rs13279850 chr8:87477800 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.16 -0.36 5.04e-12 Caudate activity during reward; LUSC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs1941687 0.563 rs7232237 chr18:31324934 C/T cg27147174 chr7:100797783 AP1S1 0.53 8.04 0.4 1.58e-14 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9902453 0.967 rs62070344 chr17:28476997 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.52 7.83 0.39 6.58e-14 Coffee consumption (cups per day); LUSC cis rs13006833 0.703 rs291459 chr2:191181527 T/C cg21644426 chr2:191273491 MFSD6 0.43 6.16 0.32 2.13e-9 Urinary metabolites; LUSC cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.74 0.35 6.88e-11 Rheumatoid arthritis; LUSC cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg03146154 chr1:46216737 IPP 0.54 7.73 0.39 1.27e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs757110 0.745 rs10734252 chr11:17404839 G/A cg15432903 chr11:17409602 KCNJ11 0.62 11.13 0.52 1.09e-24 Type 2 diabetes; LUSC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg09085632 chr11:111637200 PPP2R1B -1.05 -17.32 -0.69 2.06e-48 Primary sclerosing cholangitis; LUSC cis rs2095921 1 rs2095921 chr1:11033322 C/G cg27631724 chr1:11040367 C1orf127 0.55 9.55 0.46 2.88e-19 Male-pattern baldness; LUSC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg00603274 chr11:61596626 FADS2 -0.58 -7.98 -0.4 2.36e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs6722750 0.716 rs6546057 chr2:64414165 A/G cg22352474 chr2:64371530 PELI1 -0.49 -7.28 -0.37 2.48e-12 Neuroticism; LUSC cis rs17270561 0.779 rs12209218 chr6:25887776 C/A cg16482183 chr6:26056742 HIST1H1C 0.87 11.6 0.54 2.22e-26 Iron status biomarkers; LUSC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.99 -0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs2455601 0.786 rs2568070 chr11:8976893 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.52 -0.34 2.55e-10 Schizophrenia; LUSC cis rs4356932 1.000 rs4401475 chr4:76975924 T/C cg00809888 chr4:76862425 NAAA 0.34 5.7 0.3 2.6e-8 Blood protein levels; LUSC trans rs11098499 0.863 rs17050695 chr4:120489527 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 7.04 0.36 1.09e-11 Corneal astigmatism; LUSC cis rs7927771 0.524 rs12362318 chr11:47682671 T/C cg18512352 chr11:47633146 NA 0.28 5.79 0.3 1.63e-8 Subjective well-being; LUSC cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg05347473 chr6:146136440 FBXO30 -0.6 -10.71 -0.51 3.44e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg08680598 chr22:49984980 NA -0.32 -5.97 -0.31 6.16e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg25258033 chr6:167368657 RNASET2 0.39 6.27 0.32 1.12e-9 Crohn's disease; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg21782813 chr7:2030301 MAD1L1 0.5 8.38 0.42 1.52e-15 Bipolar disorder and schizophrenia; LUSC cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg08045932 chr20:61659980 NA 0.57 9.7 0.47 9.37e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg19680485 chr15:31195859 MTMR15 0.48 6.41 0.33 5.06e-10 Huntington's disease progression; LUSC cis rs4499344 0.576 rs259280 chr19:33161452 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.75 11.51 0.53 4.77e-26 Mean platelet volume; LUSC cis rs7107174 1.000 rs55761949 chr11:77993860 A/G cg02023728 chr11:77925099 USP35 0.48 6.97 0.36 1.69e-11 Testicular germ cell tumor; LUSC cis rs12908161 0.683 rs12903256 chr15:85308141 G/T cg17507749 chr15:85114479 UBE2QP1 0.44 5.95 0.31 6.93e-9 Schizophrenia; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg24813613 chr7:1882135 MAD1L1 -0.43 -7.16 -0.36 5.04e-12 Bipolar disorder and schizophrenia; LUSC cis rs16976116 0.806 rs28466870 chr15:55495113 C/T cg11288833 chr15:55489084 RSL24D1 0.49 5.8 0.3 1.53e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6570726 0.967 rs1396648 chr6:145785248 C/A cg23711669 chr6:146136114 FBXO30 -0.7 -12.1 -0.55 3.5e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg19812747 chr11:111475976 SIK2 0.54 8.0 0.4 2e-14 Primary sclerosing cholangitis; LUSC cis rs6456156 0.603 rs2345754 chr6:167484361 T/C cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg09021430 chr5:549028 NA -0.53 -6.97 -0.36 1.7e-11 Lung disease severity in cystic fibrosis; LUSC cis rs11756438 0.572 rs2638541 chr6:119003743 A/T cg21191810 chr6:118973309 C6orf204 0.35 5.91 0.31 8.23e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs765787 0.530 rs11636395 chr15:45535684 G/C cg24006582 chr15:45444508 DUOX1 -0.62 -8.85 -0.44 5.25e-17 Uric acid levels; LUSC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg14784868 chr12:69753453 YEATS4 0.89 15.68 0.65 6.48e-42 Cerebrospinal fluid biomarker levels; LUSC cis rs55675132 0.704 rs7553371 chr1:115591053 T/G cg01522456 chr1:115632236 TSPAN2 -0.47 -5.7 -0.3 2.63e-8 Schizophrenia; LUSC cis rs524023 0.957 rs528211 chr11:64351721 C/T cg07220939 chr11:64358617 SLC22A12 0.23 5.9 0.31 9.15e-9 Urate levels in obese individuals; LUSC cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.12 0.55 2.98e-28 Motion sickness; LUSC trans rs6582630 0.555 rs34730221 chr12:38405140 C/T cg06521331 chr12:34319734 NA 0.38 6.04 0.31 4.21e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg00071950 chr4:10020882 SLC2A9 -0.5 -8.34 -0.42 2.01e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26418507 chr12:54121361 CALCOCO1 0.43 6.07 0.32 3.44e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.28 0.62 1.92e-36 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg05347473 chr6:146136440 FBXO30 0.48 7.9 0.4 4.04e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7177699 0.557 rs8026598 chr15:79112938 A/G cg15571903 chr15:79123663 NA 0.31 5.86 0.31 1.13e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg16680214 chr1:154839983 KCNN3 -0.51 -9.68 -0.47 1.08e-19 Prostate cancer; LUSC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg13385521 chr17:29058706 SUZ12P 0.63 7.04 0.36 1.13e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg11764359 chr7:65958608 NA 0.69 6.99 0.36 1.51e-11 Diabetic kidney disease; LUSC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg07362569 chr17:61921086 SMARCD2 0.36 7.27 0.37 2.63e-12 Prudent dietary pattern; LUSC cis rs9326248 0.559 rs10892064 chr11:116896553 G/C cg01368799 chr11:117014884 PAFAH1B2 0.61 9.46 0.46 5.81e-19 Blood protein levels; LUSC cis rs317689 0.581 rs315132 chr12:69761996 G/C cg11871910 chr12:69753446 YEATS4 0.63 9.26 0.45 2.61e-18 Response to diuretic therapy; LUSC cis rs10489202 1.000 rs7535138 chr1:167931462 T/G cg24449463 chr1:168025552 DCAF6 -0.58 -7.37 -0.37 1.32e-12 Schizophrenia; LUSC cis rs2652834 0.904 rs34786874 chr15:63397504 A/G cg05507819 chr15:63340323 TPM1 0.68 8.27 0.41 3.21e-15 HDL cholesterol; LUSC cis rs9788682 1.000 rs12438181 chr15:78812098 G/A cg06917634 chr15:78832804 PSMA4 -0.58 -7.15 -0.36 5.64e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11190604 1.000 rs3750633 chr10:102308214 C/T cg16342193 chr10:102329863 NA -0.38 -6.74 -0.35 7.13e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg27121462 chr16:89883253 FANCA 0.42 6.41 0.33 4.93e-10 Vitiligo; LUSC cis rs9790314 1.000 rs189270 chr3:161063504 T/C cg03342759 chr3:160939853 NMD3 -0.49 -8.24 -0.41 3.96e-15 Morning vs. evening chronotype; LUSC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg23791538 chr6:167370224 RNASET2 -0.35 -5.65 -0.3 3.46e-8 Crohn's disease; LUSC cis rs7241530 0.717 rs28612511 chr18:75889196 T/G cg14642773 chr18:75888474 NA 0.36 6.01 0.31 4.91e-9 Educational attainment (years of education); LUSC cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.41e-9 Crohn's disease; LUSC cis rs7179456 0.545 rs605928 chr15:59046163 C/G cg05156742 chr15:59063176 FAM63B 0.52 7.87 0.4 4.88e-14 Asperger disorder; LUSC cis rs929596 0.564 rs2741042 chr2:234565917 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.97 -0.31 5.94e-9 Total bilirubin levels in HIV-1 infection; LUSC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg08213375 chr14:104286397 PPP1R13B 0.45 7.73 0.39 1.26e-13 Reticulocyte count; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg17968037 chr7:100024898 ZCWPW1 -0.44 -6.27 -0.32 1.13e-9 Platelet count; LUSC cis rs13315871 0.929 rs13080398 chr3:58300282 A/G cg12435725 chr3:58293450 RPP14 -0.74 -7.47 -0.38 7.23e-13 Cholesterol, total; LUSC trans rs12210905 0.920 rs9348759 chr6:27290888 C/T cg11837749 chr1:55047332 ACOT11 0.66 6.3 0.33 9.13e-10 Hip circumference adjusted for BMI; LUSC trans rs6952808 0.723 rs4721282 chr7:2025040 A/G cg04565464 chr8:145669602 NFKBIL2 0.38 6.39 0.33 5.72e-10 Bipolar disorder and schizophrenia; LUSC cis rs7100689 0.784 rs10736342 chr10:82130005 A/G cg00277334 chr10:82204260 NA -0.49 -6.77 -0.35 5.89e-11 Post bronchodilator FEV1; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg20682991 chr2:74981952 NA -0.4 -6.27 -0.32 1.09e-9 Educational attainment (years of education); LUSC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.32e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.930 rs7590340 chr2:15601441 C/T cg19274914 chr2:15703543 NA 0.46 9.1 0.45 8.11e-18 Educational attainment (years of education); LUSC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg06671706 chr8:8559999 CLDN23 0.49 6.61 0.34 1.52e-10 Obesity-related traits; LUSC cis rs79976124 0.837 rs74327235 chr6:66648353 T/A cg07460842 chr6:66804631 NA 0.73 9.11 0.45 7.89e-18 Type 2 diabetes; LUSC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg11632617 chr15:75315747 PPCDC 0.5 6.09 0.32 3.05e-9 Blood trace element (Zn levels); LUSC cis rs478304 0.817 rs524475 chr11:65518065 T/A cg05805236 chr11:65401703 PCNXL3 0.4 6.79 0.35 5.06e-11 Acne (severe); LUSC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg01097406 chr16:89675127 NA 0.46 9.24 0.45 3e-18 Vitiligo; LUSC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.24 -0.41 3.87e-15 Intelligence (multi-trait analysis); LUSC cis rs910316 0.763 rs175047 chr14:75479039 C/G cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.53 -0.38 4.75e-13 Height; LUSC trans rs10435719 0.773 rs7842810 chr8:11794163 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.22e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6693567 0.507 rs4970964 chr1:150458029 A/G cg15654264 chr1:150340011 RPRD2 0.43 6.85 0.35 3.57e-11 Migraine; LUSC cis rs56399783 0.614 rs11772508 chr7:2771504 A/C cg19731401 chr7:2775893 GNA12 -0.62 -7.88 -0.4 4.64e-14 Childhood ear infection; LUSC trans rs4596713 0.538 rs7030146 chr9:71756390 T/G cg25283916 chr1:242222868 NA -0.32 -6.59 -0.34 1.69e-10 Headache; LUSC cis rs7599312 0.586 rs4404217 chr2:213385817 G/A cg16329650 chr2:213403929 ERBB4 0.52 7.54 0.38 4.42e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg03579872 chr1:53393473 SCP2 -0.4 -5.76 -0.3 1.94e-8 Monocyte count; LUSC cis rs9837602 1.000 rs35844878 chr3:99796626 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.51 6.29 0.33 1.01e-9 Breast cancer; LUSC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03517284 chr6:25882590 NA -0.67 -11.33 -0.53 2.19e-25 Intelligence (multi-trait analysis); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg05922972 chr15:77362853 TSPAN3 0.48 6.11 0.32 2.76e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9341808 0.754 rs3805885 chr6:80996751 C/G cg08355045 chr6:80787529 NA -0.55 -9.64 -0.47 1.51e-19 Sitting height ratio; LUSC cis rs10779751 0.922 rs2746637 chr1:11275588 A/G cg08854313 chr1:11322531 MTOR 0.86 14.41 0.62 6.16e-37 Body mass index; LUSC cis rs4423214 0.802 rs2276358 chr11:71184498 G/A cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs7119 0.717 rs11635567 chr15:77819515 A/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.63 -0.34 1.34e-10 Type 2 diabetes; LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg05165339 chr4:1420672 NA 0.28 6.2 0.32 1.66e-9 Obesity-related traits; LUSC cis rs965469 0.652 rs4507156 chr20:3228460 A/G cg25506879 chr20:3388711 C20orf194 0.45 6.13 0.32 2.44e-9 IFN-related cytopenia; LUSC cis rs868036 0.681 rs4776981 chr15:68109474 G/A cg24579218 chr15:68104479 NA -0.39 -6.81 -0.35 4.68e-11 Restless legs syndrome; LUSC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg26695010 chr11:65641043 EFEMP2 0.46 6.79 0.35 5.08e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg10862848 chr6:42927986 GNMT -0.28 -6.78 -0.35 5.49e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1538970 0.962 rs7544178 chr1:45819069 C/T cg06784218 chr1:46089804 CCDC17 0.33 5.91 0.31 8.22e-9 Platelet count; LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg00814883 chr7:100076585 TSC22D4 -0.67 -8.3 -0.41 2.54e-15 Platelet count; LUSC cis rs11122272 0.735 rs2474630 chr1:231535335 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.03 0.48 7.06e-21 Hemoglobin concentration; LUSC cis rs3813567 0.759 rs12594550 chr15:78959037 C/G cg24631222 chr15:78858424 CHRNA5 -0.55 -6.36 -0.33 6.82e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs12681287 0.640 rs4587306 chr8:87385511 T/C cg00550725 chr8:87521180 FAM82B -0.43 -5.73 -0.3 2.21e-8 Caudate activity during reward; LUSC cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg03517284 chr6:25882590 NA -0.52 -9.71 -0.47 8.33e-20 Blood metabolite levels; LUSC cis rs9902453 0.765 rs3102560 chr17:28029938 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.31 0.53 2.56e-25 Coffee consumption (cups per day); LUSC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg12463550 chr7:65579703 CRCP 0.63 5.7 0.3 2.58e-8 Gout; LUSC cis rs41271473 0.750 rs17352829 chr1:228889664 A/G cg10167378 chr1:228756711 NA 0.53 6.26 0.32 1.17e-9 Chronic lymphocytic leukemia; LUSC cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11112613 0.775 rs10778413 chr12:105962118 G/A cg03607813 chr12:105948248 NA 0.81 11.2 0.52 6.18e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.41 -6.11 -0.32 2.81e-9 Renal function-related traits (BUN); LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg00945038 chr17:61921165 SMARCD2 -0.53 -9.32 -0.45 1.57e-18 Prudent dietary pattern; LUSC cis rs7799006 0.929 rs6461233 chr7:2261468 G/A cg08027265 chr7:2291960 NA -0.43 -7.37 -0.37 1.38e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2236918 1.000 rs1635511 chr1:242026172 C/T cg17736920 chr1:242011382 EXO1 0.44 6.86 0.35 3.34e-11 Menopause (age at onset); LUSC cis rs13385 0.769 rs17118781 chr5:139642929 C/T cg26211634 chr5:139558579 C5orf32 0.47 6.7 0.34 9.01e-11 Atrial fibrillation; LUSC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.71 -0.43 1.38e-16 Lung cancer; LUSC cis rs9653442 0.593 rs6737502 chr2:100862903 C/T cg07810366 chr2:100720526 AFF3 -0.4 -6.43 -0.33 4.29e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg03929089 chr4:120376271 NA -0.79 -10.1 -0.48 4.02e-21 Coronary artery disease; LUSC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11644478 chr21:40555479 PSMG1 0.93 18.07 0.7 2.16e-51 Cognitive function; LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg13047869 chr3:10149882 C3orf24 0.59 7.71 0.39 1.49e-13 Alzheimer's disease; LUSC cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg12219531 chr12:120966889 COQ5 0.6 8.08 0.4 1.2e-14 High light scatter reticulocyte count; LUSC trans rs7824557 0.602 rs11781375 chr8:11204532 A/G cg06636001 chr8:8085503 FLJ10661 0.45 6.42 0.33 4.57e-10 Retinal vascular caliber; LUSC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg26677194 chr12:130822605 PIWIL1 0.57 8.59 0.43 3.4e-16 Menopause (age at onset); LUSC cis rs9527 0.590 rs11191544 chr10:104827198 C/G cg04362960 chr10:104952993 NT5C2 0.62 9.7 0.47 9.07e-20 Arsenic metabolism; LUSC cis rs765787 0.530 rs12915027 chr15:45512626 G/A cg24006582 chr15:45444508 DUOX1 0.67 9.7 0.47 9.32e-20 Uric acid levels; LUSC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs12928939 0.769 rs34680964 chr16:71658594 G/A cg08717414 chr16:71523259 ZNF19 -0.43 -5.96 -0.31 6.32e-9 Post bronchodilator FEV1; LUSC cis rs7100689 0.646 rs10736345 chr10:82134140 C/T cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs1997103 1.000 rs12718956 chr7:55407763 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs936229 0.906 rs9210 chr15:75128501 T/C cg10253484 chr15:75165896 SCAMP2 -0.5 -6.44 -0.33 4.2e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs8060686 0.545 rs11043 chr16:68262958 G/A cg27539214 chr16:67997921 SLC12A4 -0.55 -6.89 -0.35 2.85e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg07424592 chr7:64974309 NA 0.66 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs3099143 1.000 rs3102709 chr15:77072260 C/T cg21673338 chr15:77095150 SCAPER -0.84 -8.22 -0.41 4.7e-15 Recalcitrant atopic dermatitis; LUSC cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg05347473 chr6:146136440 FBXO30 -0.49 -8.24 -0.41 4.04e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs9309473 1.000 rs3813227 chr2:73651967 A/G cg20560298 chr2:73613845 ALMS1 0.52 7.31 0.37 1.97e-12 Metabolite levels; LUSC cis rs11098499 0.562 rs2389879 chr4:120557684 G/A cg09307838 chr4:120376055 NA -0.58 -8.86 -0.44 4.9e-17 Corneal astigmatism; LUSC cis rs7582720 1.000 rs72934732 chr2:203739856 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs13064411 0.696 rs7610638 chr3:113139656 A/G cg18753928 chr3:113234510 CCDC52 -0.49 -7.34 -0.37 1.62e-12 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg24675658 chr1:53192096 ZYG11B 0.59 9.22 0.45 3.51e-18 Monocyte count; LUSC cis rs72781680 0.800 rs72790306 chr2:24111311 T/G cg08917208 chr2:24149416 ATAD2B 0.97 10.29 0.49 9.41e-22 Lymphocyte counts; LUSC cis rs9309473 1.000 rs6740223 chr2:73653332 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.54 -0.34 2.34e-10 Metabolite levels; LUSC cis rs7106204 0.748 rs2403891 chr11:24213130 C/T ch.11.24196551F chr11:24239977 NA 1.13 12.76 0.57 1.21e-30 Response to Homoharringtonine (cytotoxicity); LUSC trans rs7937682 0.883 rs566647 chr11:111466607 A/G cg18187862 chr3:45730750 SACM1L -0.5 -6.35 -0.33 7.11e-10 Primary sclerosing cholangitis; LUSC cis rs4268898 0.662 rs9917315 chr2:24431501 C/A cg06627628 chr2:24431161 ITSN2 -0.89 -13.24 -0.59 1.81e-32 Asthma; LUSC cis rs921968 0.643 rs539451 chr2:219426972 T/C cg02176678 chr2:219576539 TTLL4 0.61 11.1 0.52 1.41e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs909002 0.703 rs4949460 chr1:32143138 A/G cg01639898 chr1:32083012 HCRTR1 -0.25 -5.81 -0.3 1.45e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs524023 1.000 rs11602903 chr11:64358241 A/T cg07220939 chr11:64358617 SLC22A12 -0.22 -5.67 -0.3 3.12e-8 Urate levels in obese individuals; LUSC cis rs10193935 0.901 rs12619348 chr2:42625586 C/T cg27598129 chr2:42591480 NA -0.61 -8.15 -0.41 7.4e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg19622623 chr12:86230825 RASSF9 0.4 5.8 0.3 1.51e-8 Major depressive disorder; LUSC cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg04673462 chr1:38461896 NA 0.4 6.49 0.33 3.18e-10 Coronary artery disease; LUSC cis rs9300255 0.602 rs1051431 chr12:123645803 G/A cg00376283 chr12:123451042 ABCB9 0.67 8.44 0.42 9.73e-16 Neutrophil percentage of white cells; LUSC cis rs7605827 0.930 rs12692266 chr2:15572380 T/C cg19274914 chr2:15703543 NA 0.48 9.18 0.45 4.52e-18 Educational attainment (years of education); LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg05863683 chr7:1912471 MAD1L1 0.3 5.73 0.3 2.22e-8 Bipolar disorder and schizophrenia; LUSC cis rs1124376 0.748 rs67713322 chr3:20148258 G/T cg05072819 chr3:20081367 KAT2B 0.67 7.82 0.39 6.8e-14 Bipolar disorder and schizophrenia; LUSC cis rs965604 0.965 rs12899351 chr15:78792398 T/C cg18825076 chr15:78729989 IREB2 -0.43 -6.82 -0.35 4.31e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs8040855 0.826 rs6496771 chr15:85705328 A/G cg04831495 chr15:85060580 GOLGA6L5 0.41 6.04 0.31 4.02e-9 Bulimia nervosa; LUSC cis rs4654899 1.000 rs61117207 chr1:21394374 A/C cg01072550 chr1:21505969 NA -0.53 -8.05 -0.4 1.44e-14 Superior frontal gyrus grey matter volume; LUSC cis rs7224314 1.000 rs62085808 chr17:65357692 G/A cg01507342 chr17:65387096 PITPNC1 -0.39 -6.91 -0.35 2.4e-11 Diisocyanate-induced asthma; LUSC cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg23711669 chr6:146136114 FBXO30 0.92 17.7 0.7 6.72e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs11700980 0.591 rs2832025 chr21:30114322 C/G cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC trans rs2975734 0.674 rs6983870 chr8:10111294 G/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.06 -0.31 3.62e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs2242194 0.816 rs6671688 chr1:154994265 T/C cg12436631 chr1:155007014 DCST1;DCST2 0.45 10.18 0.49 2.22e-21 Schizophrenia; LUSC cis rs6714710 0.603 rs35424768 chr2:98395653 A/C cg26665480 chr2:98280029 ACTR1B 0.58 8.41 0.42 1.18e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg11812906 chr14:75593930 NEK9 -0.62 -10.08 -0.48 4.95e-21 Height; LUSC cis rs1065852 0.526 rs739296 chr22:42389948 A/G cg22189786 chr22:42395067 WBP2NL -0.44 -5.97 -0.31 6.12e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg07148914 chr20:33460835 GGT7 0.46 6.73 0.35 7.48e-11 Height; LUSC cis rs61931739 0.817 rs1687002 chr12:34170263 T/C cg06521331 chr12:34319734 NA -0.34 -5.84 -0.3 1.24e-8 Morning vs. evening chronotype; LUSC cis rs55883249 1.000 rs11676903 chr2:9763201 G/C cg23886495 chr2:9695866 ADAM17 0.49 5.84 0.3 1.24e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg06671706 chr8:8559999 CLDN23 0.5 6.83 0.35 3.98e-11 Obesity-related traits; LUSC trans rs61931739 0.517 rs10844815 chr12:34245150 G/A cg13010199 chr12:38710504 ALG10B 0.54 8.41 0.42 1.21e-15 Morning vs. evening chronotype; LUSC cis rs16867321 0.950 rs12477283 chr2:181501355 G/T cg23363182 chr2:181467187 NA -0.45 -5.85 -0.3 1.2e-8 Obesity; LUSC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.96 -0.51 4.26e-24 Schizophrenia; LUSC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg05347473 chr6:146136440 FBXO30 0.59 9.67 0.47 1.16e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7615316 0.934 rs2227928 chr3:142281612 A/G cg16271453 chr3:142027066 XRN1 -0.37 -6.47 -0.33 3.43e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9309473 0.607 rs2421489 chr2:73593448 A/G cg20560298 chr2:73613845 ALMS1 -0.59 -9.11 -0.45 7.73e-18 Metabolite levels; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg26354017 chr1:205819088 PM20D1 -0.79 -15.27 -0.64 2.65e-40 Monocyte percentage of white cells; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.3 -5.74 -0.3 2.09e-8 Lymphocyte counts; LUSC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs17253792 0.558 rs10083353 chr14:56066370 G/T cg01858014 chr14:56050164 KTN1 -0.9 -7.33 -0.37 1.71e-12 Putamen volume; LUSC cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.83 -10.92 -0.51 6.32e-24 Schizophrenia; LUSC cis rs7577851 0.672 rs111506194 chr2:69631579 G/A cg10773587 chr2:69614142 GFPT1 0.52 5.85 0.3 1.19e-8 Parkinson's disease (age of onset); LUSC trans rs6951245 1.000 rs79422648 chr7:1080241 T/C cg13565492 chr6:43139072 SRF -0.56 -6.01 -0.31 4.81e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.53 -0.42 5.2e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs61931739 0.500 rs11053280 chr12:34559297 G/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg18404041 chr3:52824283 ITIH1 -0.62 -12.3 -0.56 6.21e-29 Bipolar disorder; LUSC cis rs11098499 0.754 rs28652763 chr4:120242312 C/T cg24375607 chr4:120327624 NA 0.76 12.23 0.56 1.14e-28 Corneal astigmatism; LUSC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg08677398 chr8:58056175 NA 0.51 6.87 0.35 3.25e-11 Developmental language disorder (linguistic errors); LUSC cis rs75804782 0.641 rs72987309 chr2:239348025 A/G cg18131467 chr2:239335373 ASB1 -0.75 -6.89 -0.35 2.71e-11 Morning vs. evening chronotype;Chronotype; LUSC trans rs80264589 1 rs80264589 chr6:26927602 G/A cg06606381 chr12:133084897 FBRSL1 -0.87 -7.83 -0.39 6.68e-14 Lung cancer;Intelligence (multi-trait analysis); LUSC cis rs10791323 0.519 rs329663 chr11:133754543 A/G cg00579200 chr11:133705235 NA -0.39 -5.86 -0.31 1.12e-8 Childhood ear infection; LUSC cis rs7584330 0.780 rs7582828 chr2:238378476 A/C cg16989719 chr2:238392110 NA 0.38 6.73 0.35 7.24e-11 Prostate cancer; LUSC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC cis rs1560104 0.709 rs9806858 chr16:12704421 T/C cg02946846 chr16:12632861 SNX29 0.33 6.14 0.32 2.28e-9 Obesity-related traits; LUSC cis rs7267979 0.932 rs6115215 chr20:25562500 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.6 0.69 1.59e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.86 -0.35 3.31e-11 Developmental language disorder (linguistic errors); LUSC cis rs2455601 0.882 rs11042116 chr11:8928472 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -7.81 -0.39 7.35e-14 Schizophrenia; LUSC cis rs12760731 0.720 rs12022646 chr1:178355821 A/G cg00404053 chr1:178313656 RASAL2 0.6 6.28 0.33 1.03e-9 Obesity-related traits; LUSC cis rs7177699 0.557 rs7164479 chr15:79123054 C/T cg15571903 chr15:79123663 NA 0.33 6.28 0.32 1.07e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2073300 1.000 rs12625160 chr20:23442008 T/C cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.89e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg19468946 chr17:37922297 IKZF3 -0.44 -6.95 -0.36 1.97e-11 Self-reported allergy; LUSC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.05e-8 Reticulocyte fraction of red cells; LUSC cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg19628046 chr18:33552617 C18orf21 0.49 6.03 0.31 4.36e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs55665837 0.559 rs11023209 chr11:14422600 T/C cg19336497 chr11:14380999 RRAS2 -0.54 -11.51 -0.53 4.79e-26 Vitamin D levels; LUSC cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.26 -0.37 2.81e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs8092503 1.000 rs12457718 chr18:52499626 T/C cg12377874 chr18:52495404 RAB27B 0.32 5.67 0.3 3.12e-8 Childhood body mass index; LUSC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -10.26 -0.49 1.19e-21 Developmental language disorder (linguistic errors); LUSC cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg06784218 chr1:46089804 CCDC17 0.48 9.5 0.46 4.33e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22618350 chr1:91487603 ZNF644 0.45 6.26 0.32 1.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.23 0.49 1.55e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23505970 chr6:90529759 MDN1 0.45 6.48 0.33 3.32e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.9 -0.4 4.01e-14 Joint mobility (Beighton score); LUSC cis rs4474465 0.790 rs10899554 chr11:78265667 T/G cg27205649 chr11:78285834 NARS2 0.52 6.12 0.32 2.64e-9 Alzheimer's disease (survival time); LUSC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg09035930 chr12:129282057 SLC15A4 0.65 12.97 0.58 1.88e-31 Systemic lupus erythematosus; LUSC cis rs35000415 0.873 rs62478615 chr7:128684316 G/C cg19972273 chr7:128594194 NA 0.67 6.75 0.35 6.46e-11 Systemic lupus erythematosus; LUSC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -6.43 -0.33 4.39e-10 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg11584989 chr19:19387371 SF4 0.57 6.77 0.35 5.94e-11 Bipolar disorder; LUSC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg00033643 chr7:134001901 SLC35B4 0.45 7.16 0.36 5.28e-12 Mean platelet volume; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg22153345 chr8:651449 ERICH1 -0.74 -5.99 -0.31 5.44e-9 Cognitive performance; LUSC cis rs8068544 0.606 rs77681389 chr17:40154419 T/C cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -1.24 -11.41 -0.53 1.14e-25 Reticulocyte fraction of red cells;Reticulocyte count; LUSC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg13206674 chr6:150067644 NUP43 0.62 9.96 0.48 1.21e-20 Lung cancer; LUSC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg12257692 chr3:49977190 RBM6 0.24 6.57 0.34 1.93e-10 Intelligence (multi-trait analysis); LUSC cis rs2191566 0.959 rs7255623 chr19:44510906 G/C cg03039196 chr19:44506973 ZNF230 0.36 5.93 0.31 7.69e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg13393036 chr8:95962371 TP53INP1 -0.45 -9.43 -0.46 7.05e-19 Type 2 diabetes; LUSC cis rs7223966 0.921 rs2854207 chr17:61947107 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.0 0.36 1.39e-11 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs7495211 0.529 rs12594533 chr15:98624254 A/G cg08901157 chr15:56033728 PRTG 0.35 6.21 0.32 1.6e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg26727032 chr16:67993705 SLC12A4 -0.45 -5.94 -0.31 7.32e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs3772130 0.962 rs6768621 chr3:121530274 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.22 0.49 1.66e-21 Cognitive performance; LUSC cis rs3820928 1.000 rs3731593 chr2:227773924 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -8.13 -0.41 8.52e-15 Pulmonary function; LUSC cis rs7759001 0.857 rs10080567 chr6:27363058 G/C cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.73e-8 Glomerular filtration rate (creatinine); LUSC trans rs6582630 0.502 rs2387603 chr12:38353389 A/C cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.28e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs73206853 0.841 rs73206886 chr12:110851190 T/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg07414643 chr4:187882934 NA 0.56 10.6 0.5 7.74e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs9549367 0.756 rs2302756 chr13:113900197 G/A cg00898013 chr13:113819073 PROZ 0.55 7.93 0.4 3.28e-14 Platelet distribution width; LUSC cis rs1577917 0.771 rs2475790 chr6:86368068 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.69 -0.43 1.7e-16 Response to antipsychotic treatment; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg19902918 chr1:28586105 SESN2 0.42 6.71 0.34 8.31e-11 Risky sexual behaviors in alcohol dependence; LUSC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg10664184 chr19:17420304 DDA1 0.53 6.73 0.35 7.44e-11 Systemic lupus erythematosus; LUSC cis rs28735056 0.967 rs11662248 chr18:77619009 C/T cg20368463 chr18:77673604 PQLC1 -0.53 -7.56 -0.38 3.96e-13 Schizophrenia; LUSC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg04267008 chr7:1944627 MAD1L1 -0.48 -6.92 -0.35 2.27e-11 Schizophrenia; LUSC cis rs3849570 0.615 rs1851918 chr3:81980557 C/T cg07356753 chr3:81810745 GBE1 -0.43 -6.38 -0.33 5.92e-10 Waist circumference;Body mass index; LUSC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.06 -0.4 1.35e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg26727032 chr16:67993705 SLC12A4 -0.45 -5.96 -0.31 6.44e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2932538 0.961 rs1238 chr1:113214097 G/A cg22162597 chr1:113214053 CAPZA1 -0.68 -9.7 -0.47 9.01e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 13.43 0.59 3.62e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs1801251 1.000 rs991873 chr2:233711046 A/G cg25237894 chr2:233734115 C2orf82 -0.36 -6.81 -0.35 4.61e-11 Coronary artery disease; LUSC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg22800045 chr5:56110881 MAP3K1 0.72 9.08 0.45 9.41e-18 Initial pursuit acceleration; LUSC trans rs6502050 0.835 rs8078087 chr17:80113322 T/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs2836633 0.929 rs62217518 chr21:40033189 T/G cg12884169 chr21:40033163 ERG 0.61 12.26 0.56 8.41e-29 Coronary artery disease; LUSC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg09455208 chr3:40491958 NA 0.54 9.78 0.47 5.15e-20 Renal cell carcinoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19826439 chr1:226297528 NA -0.54 -6.68 -0.34 1.02e-10 Bipolar disorder and schizophrenia; LUSC cis rs3772130 0.583 rs11710169 chr3:121426655 A/G cg20356878 chr3:121714668 ILDR1 0.51 8.2 0.41 5.35e-15 Cognitive performance; LUSC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg17747265 chr1:1875780 NA -0.75 -17.71 -0.7 5.82e-50 Body mass index; LUSC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.75 9.81 0.47 4.09e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12586317 0.620 rs28870452 chr14:35536878 C/A cg16230307 chr14:35515116 FAM177A1 0.78 10.01 0.48 8.33e-21 Psoriasis; LUSC cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg08975724 chr8:8085496 FLJ10661 -0.45 -7.28 -0.37 2.43e-12 Mood instability; LUSC cis rs11155671 0.530 rs7768626 chr6:150207962 G/T cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.15e-11 Testicular germ cell tumor; LUSC cis rs11098499 0.913 rs13126596 chr4:120140729 A/G cg24375607 chr4:120327624 NA 0.73 10.93 0.51 5.82e-24 Corneal astigmatism; LUSC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg20573242 chr4:122745356 CCNA2 0.64 9.03 0.44 1.36e-17 Type 2 diabetes; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.54 -7.62 -0.38 2.6e-13 Alzheimer's disease (late onset); LUSC cis rs11608355 0.960 rs3742021 chr12:109883117 T/C cg05360138 chr12:110035743 NA 0.45 6.2 0.32 1.62e-9 Neuroticism; LUSC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.7 -0.47 9.21e-20 Prostate cancer; LUSC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.45 0.33 3.87e-10 Lung cancer; LUSC cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg05347473 chr6:146136440 FBXO30 0.46 7.97 0.4 2.52e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg26380479 chr7:97908229 NA -0.27 -6.07 -0.32 3.46e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs8002861 0.619 rs9567289 chr13:44437104 C/T cg12856521 chr11:46389249 DGKZ 0.43 6.44 0.33 4.28e-10 Leprosy; LUSC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.38 -7.37 -0.37 1.34e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg19812747 chr11:111475976 SIK2 0.56 8.2 0.41 5.38e-15 Primary sclerosing cholangitis; LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -7.1 -0.36 7.57e-12 Bipolar disorder; LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg00684032 chr4:1343700 KIAA1530 0.33 5.69 0.3 2.72e-8 Obesity-related traits; LUSC cis rs9399135 0.967 rs45544135 chr6:135324051 T/C cg22676075 chr6:135203613 NA 0.48 7.54 0.38 4.48e-13 Red blood cell count; LUSC cis rs3736594 0.840 rs57238885 chr2:27974260 C/G cg27432699 chr2:27873401 GPN1 0.65 9.07 0.44 1.03e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs3812831 0.643 rs7322339 chr13:114929726 C/A cg08824895 chr13:115047677 UPF3A 0.59 9.04 0.44 1.32e-17 Schizophrenia; LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg03354898 chr7:1950403 MAD1L1 -0.42 -8.28 -0.41 3.03e-15 Bipolar disorder and schizophrenia; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg12419862 chr22:24373484 LOC391322 -0.88 -14.3 -0.62 1.55e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4555082 1.000 rs7149013 chr14:105759840 T/C cg27165867 chr14:105738592 BRF1 -0.55 -7.81 -0.39 7.43e-14 Mean platelet volume;Platelet distribution width; LUSC trans rs12579753 1.000 rs2400979 chr12:82197353 T/C cg07923666 chr12:49932857 KCNH3 -0.52 -6.51 -0.34 2.74e-10 Resting heart rate; LUSC cis rs453301 0.686 rs6987107 chr8:8893581 A/G cg15556689 chr8:8085844 FLJ10661 -0.61 -9.89 -0.48 2.15e-20 Joint mobility (Beighton score); LUSC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg06108461 chr20:60628389 TAF4 -0.71 -9.35 -0.46 1.31e-18 Obesity-related traits; LUSC cis rs6460942 0.591 rs62451461 chr7:12355480 G/A cg06484146 chr7:12443880 VWDE -0.57 -5.85 -0.3 1.17e-8 Coronary artery disease; LUSC trans rs2243480 1.000 rs1964692 chr7:65454183 G/A cg10756647 chr7:56101905 PSPH 0.86 8.41 0.42 1.18e-15 Diabetic kidney disease; LUSC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08109568 chr15:31115862 NA -0.6 -8.29 -0.41 2.79e-15 Huntington's disease progression; LUSC cis rs16976116 0.901 rs28630909 chr15:55500102 G/A cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg13319975 chr6:146136371 FBXO30 0.51 7.71 0.39 1.44e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311676 0.656 rs56198078 chr3:58392224 G/C cg13750441 chr3:58318267 PXK 0.35 6.78 0.35 5.47e-11 Systemic lupus erythematosus; LUSC trans rs9291683 0.618 rs13137343 chr4:10043028 C/A cg26043149 chr18:55253948 FECH 0.49 7.18 0.37 4.68e-12 Bone mineral density; LUSC cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg17366294 chr4:99064904 C4orf37 0.6 10.73 0.51 2.76e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs9329221 0.686 rs35406700 chr8:10244593 A/G cg06636001 chr8:8085503 FLJ10661 0.54 7.6 0.38 2.99e-13 Neuroticism; LUSC cis rs4588572 0.643 rs10044028 chr5:77794750 C/T cg11547950 chr5:77652471 NA 0.58 8.42 0.42 1.12e-15 Triglycerides; LUSC cis rs6918586 0.658 rs1572982 chr6:26094367 G/A cg17691542 chr6:26056736 HIST1H1C -0.38 -5.67 -0.3 3.02e-8 Schizophrenia; LUSC cis rs939574 0.722 rs115402093 chr2:220096128 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.85 5.96 0.31 6.42e-9 Platelet distribution width; LUSC cis rs2933343 0.729 rs1680794 chr3:128620390 A/G cg11901034 chr3:128598214 ACAD9 -0.42 -6.68 -0.34 9.84e-11 IgG glycosylation; LUSC cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg22782873 chr19:19639568 YJEFN3 -0.51 -6.05 -0.31 3.78e-9 Bipolar disorder; LUSC cis rs12618769 0.625 rs4850880 chr2:99212417 C/T cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs7312933 0.566 rs11181454 chr12:42746486 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.81 -0.35 4.55e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg06634786 chr22:41940651 POLR3H -0.53 -6.43 -0.33 4.33e-10 Vitiligo; LUSC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg18876405 chr7:65276391 NA -0.6 -9.75 -0.47 6.36e-20 Aortic root size; LUSC cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2050392 0.928 rs6481677 chr10:30701816 A/G cg18806716 chr10:30721971 MAP3K8 -0.48 -7.81 -0.39 7.65e-14 Inflammatory bowel disease; LUSC cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.49 0.75 5.48e-61 Cognitive ability; LUSC cis rs10887741 0.646 rs12413510 chr10:89436979 T/C cg13926569 chr10:89418898 PAPSS2 0.32 6.92 0.35 2.27e-11 Exercise (leisure time); LUSC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg11244672 chr19:19639970 YJEFN3 0.64 7.68 0.39 1.76e-13 Bipolar disorder; LUSC cis rs7582180 0.607 rs6725052 chr2:100935817 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.49 -0.42 6.69e-16 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13090731 chr18:54305960 TXNL1 0.67 6.09 0.32 3.13e-9 Cognitive performance; LUSC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg09034736 chr1:150693464 HORMAD1 -0.46 -6.53 -0.34 2.39e-10 Melanoma; LUSC cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg27446573 chr6:127587934 RNF146 0.9 15.14 0.64 8.55e-40 Breast cancer; LUSC trans rs853679 0.569 rs9348798 chr6:28143011 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.16e-9 Depression; LUSC cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.78 -0.35 5.51e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.83 0.47 3.52e-20 Major depressive disorder; LUSC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg22437258 chr11:111473054 SIK2 0.53 7.5 0.38 5.65e-13 Primary sclerosing cholangitis; LUSC cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg07606381 chr6:8435919 SLC35B3 0.76 12.82 0.57 6.89e-31 Motion sickness; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs748404 0.723 rs565658 chr15:43556307 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.94 0.31 7.03e-9 Lung cancer; LUSC cis rs897984 0.760 rs11076 chr16:30995528 A/G cg00531865 chr16:30841666 NA 0.33 5.71 0.3 2.54e-8 Dementia with Lewy bodies; LUSC cis rs113835537 0.877 rs2229455 chr11:66328055 A/G cg24851651 chr11:66362959 CCS 0.46 5.9 0.31 8.71e-9 Airway imaging phenotypes; LUSC cis rs7119 0.623 rs11637932 chr15:77847353 T/G cg27398640 chr15:77910606 LINGO1 -0.33 -7.04 -0.36 1.12e-11 Type 2 diabetes; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg03188948 chr7:1209495 NA 0.4 5.95 0.31 6.88e-9 Longevity;Endometriosis; LUSC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg05043794 chr9:111880884 C9orf5 -0.38 -8.11 -0.41 9.63e-15 Menarche (age at onset); LUSC cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg01657329 chr11:68192670 LRP5 -0.44 -6.61 -0.34 1.55e-10 Total body bone mineral density; LUSC cis rs4073416 0.518 rs2184601 chr14:65897368 T/A cg03016385 chr14:66212404 NA -0.39 -5.87 -0.31 1.05e-8 N-glycan levels; LUSC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg06238570 chr21:40685208 BRWD1 -0.57 -8.9 -0.44 3.65e-17 Menarche (age at onset); LUSC cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg24642439 chr20:33292090 TP53INP2 -0.48 -7.32 -0.37 1.86e-12 Glomerular filtration rate (creatinine); LUSC cis rs934734 0.563 rs1858036 chr2:65598241 A/G cg08085232 chr2:65598271 SPRED2 -0.44 -6.9 -0.35 2.56e-11 Rheumatoid arthritis; LUSC cis rs599083 0.829 rs23691 chr11:68178668 G/A cg16797656 chr11:68205561 LRP5 -0.36 -5.86 -0.31 1.12e-8 Bone mineral density (spine); LUSC trans rs11088226 0.581 rs1967870 chr21:33882858 A/G cg09050820 chr6:167586206 TCP10L2 0.47 7.1 0.36 7.49e-12 Gastritis; LUSC cis rs8177253 0.633 rs10935073 chr3:133439184 T/C cg16414030 chr3:133502952 NA -0.39 -5.65 -0.3 3.52e-8 Iron status biomarkers; LUSC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.46 -0.33 3.7e-10 Total body bone mineral density; LUSC cis rs10207060 0.500 rs56346503 chr2:240719409 T/C cg07506560 chr2:240697449 NA 0.44 6.78 0.35 5.5e-11 Obesity-related traits; LUSC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg03806693 chr22:41940476 POLR3H 1.01 14.37 0.62 8.38e-37 Vitiligo; LUSC trans rs11098499 0.863 rs2170276 chr4:120485824 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.61 0.34 1.48e-10 Corneal astigmatism; LUSC cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.82 0.43 6.31e-17 Menopause (age at onset); LUSC trans rs656319 0.513 rs6985941 chr8:9983179 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.86 -0.35 3.39e-11 Myopia (pathological); LUSC cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg15445000 chr17:37608096 MED1 0.38 6.5 0.34 2.95e-10 Glomerular filtration rate (creatinine); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15248989 chr19:14682900 NDUFB7 0.43 6.26 0.32 1.19e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg23711669 chr6:146136114 FBXO30 0.83 14.5 0.62 2.61e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs3774749 0.565 rs2188151 chr3:50201924 A/C cg24110177 chr3:50126178 RBM5 0.43 6.71 0.34 8.5e-11 Intelligence (multi-trait analysis); LUSC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.33 5.83 0.3 1.33e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7927771 0.524 rs4752796 chr11:47841862 A/G cg20307385 chr11:47447363 PSMC3 -0.45 -6.69 -0.34 9.64e-11 Subjective well-being; LUSC cis rs7568458 0.846 rs6705971 chr2:85761417 G/T cg02493740 chr2:85810744 VAMP5 0.39 7.16 0.36 5.13e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs28647808 1.000 rs28591209 chr9:136259668 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs7043114 0.525 rs7045409 chr9:95201540 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.31 -0.33 8.98e-10 Height; LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.13 0.41 8.33e-15 Bipolar disorder; LUSC cis rs7149337 0.805 rs2999361 chr14:51605358 G/A cg23942311 chr14:51606299 NA 0.49 11.44 0.53 8.92e-26 Cancer; LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg17330251 chr7:94953956 PON1 -0.54 -10.71 -0.51 3.27e-23 Paraoxonase activity; LUSC cis rs10791097 0.765 rs7943757 chr11:130716157 C/T cg12179176 chr11:130786555 SNX19 0.65 9.98 0.48 1.03e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4604732 0.631 rs12039596 chr1:247624766 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9911578 0.967 rs7214892 chr17:57065401 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.41 6.01 0.31 4.84e-9 Intelligence (multi-trait analysis); LUSC cis rs9400467 0.528 rs56827 chr6:111623203 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.42 -0.33 4.58e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg23422044 chr7:1970798 MAD1L1 -0.57 -6.35 -0.33 7e-10 Neuroticism; LUSC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg09323728 chr8:95962352 TP53INP1 -0.36 -7.45 -0.38 8.24e-13 Type 2 diabetes; LUSC cis rs7799006 0.929 rs6951493 chr7:2257612 G/A cg08027265 chr7:2291960 NA -0.42 -7.12 -0.36 6.82e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs1949829 0.826 rs4947598 chr7:51537440 A/G cg20941110 chr15:83953819 BNC1 0.55 6.01 0.31 4.98e-9 Wegener's granulomatosis; LUSC cis rs977987 0.872 rs10781976 chr16:75314838 G/T cg03315344 chr16:75512273 CHST6 0.42 7.73 0.39 1.3e-13 Dupuytren's disease; LUSC cis rs7605827 0.866 rs13014988 chr2:15498404 C/T cg19274914 chr2:15703543 NA 0.45 8.51 0.42 6.15e-16 Educational attainment (years of education); LUSC trans rs9831754 1.000 rs3946823 chr3:78353052 G/A cg06695833 chr19:18220682 MAST3 0.48 6.06 0.31 3.76e-9 Calcium levels; LUSC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg06022373 chr22:39101656 GTPBP1 0.79 12.2 0.56 1.48e-28 Menopause (age at onset); LUSC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03517284 chr6:25882590 NA 0.38 6.5 0.33 2.97e-10 Intelligence (multi-trait analysis); LUSC cis rs9560113 0.960 rs953260 chr13:112173685 C/T cg14154082 chr13:112174009 NA 0.38 7.95 0.4 2.92e-14 Menarche (age at onset); LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg00814883 chr7:100076585 TSC22D4 -0.73 -9.76 -0.47 5.88e-20 Platelet count; LUSC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.05 -0.4 1.45e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.3 0.45 1.9e-18 Prudent dietary pattern; LUSC cis rs9649465 0.561 rs603060 chr7:123427568 A/G cg03229431 chr7:123269106 ASB15 -0.47 -7.7 -0.39 1.5700000000000001e-13 Migraine; LUSC cis rs4356932 1.000 rs4619915 chr4:76955201 A/G cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs1784581 0.928 rs1789995 chr6:162396518 C/T cg17173639 chr6:162384350 PARK2 -0.83 -15.41 -0.64 7.33e-41 Itch intensity from mosquito bite; LUSC cis rs694739 0.894 rs11601860 chr11:64110422 A/T cg02228329 chr11:64053129 BAD;GPR137 0.53 7.76 0.39 1.04e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14906687 chr6:157099894 ARID1B 0.45 6.05 0.31 3.87e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.65 -10.36 -0.49 5.43e-22 Endometrial cancer; LUSC cis rs6964587 1.000 rs58965837 chr7:91585258 T/A cg22117172 chr7:91764530 CYP51A1 0.32 5.75 0.3 1.99e-8 Breast cancer; LUSC cis rs11785400 1.000 rs9720653 chr8:143731939 T/G cg10596483 chr8:143751796 JRK 0.61 9.39 0.46 9.97e-19 Schizophrenia; LUSC cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg03146154 chr1:46216737 IPP 0.52 7.7 0.39 1.58e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg08968635 chr6:28129556 ZNF389 -0.45 -5.95 -0.31 6.69e-9 Depression; LUSC cis rs4566357 0.615 rs10177528 chr2:227913706 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -8.23 -0.41 4.2e-15 Coronary artery disease; LUSC cis rs66887589 0.967 rs1480933 chr4:120433248 C/T cg24375607 chr4:120327624 NA 0.42 6.37 0.33 6.33e-10 Diastolic blood pressure; LUSC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.0 0.4 2.1e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs62238980 0.614 rs75091642 chr22:32449078 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg15073853 chr19:18549131 ISYNA1 -0.33 -6.16 -0.32 2.13e-9 Breast cancer; LUSC cis rs2486288 0.656 rs11639349 chr15:45568260 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.79 -0.39 8.31e-14 Glomerular filtration rate; LUSC cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.86 0.35 3.29e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg04944784 chr2:26401820 FAM59B -0.69 -9.57 -0.46 2.54e-19 Gut microbiome composition (summer); LUSC cis rs11229555 1.000 rs12799215 chr11:58405674 C/T cg15696309 chr11:58395628 NA -0.68 -8.98 -0.44 2.08e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs13315871 1.000 rs4362735 chr3:58429893 C/G cg12435725 chr3:58293450 RPP14 -0.69 -7.33 -0.37 1.77e-12 Cholesterol, total; LUSC cis rs28595532 1.000 rs11098451 chr4:119717673 C/T cg21605333 chr4:119757512 SEC24D 1.14 9.16 0.45 5.52e-18 Cannabis dependence symptom count; LUSC cis rs2235642 0.821 rs8051895 chr16:1602811 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.54 0.34 2.27e-10 Coronary artery disease; LUSC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg04756594 chr16:24857601 SLC5A11 0.37 6.15 0.32 2.24e-9 Intelligence (multi-trait analysis); LUSC cis rs4663866 0.901 rs76312449 chr2:239190906 A/G cg16914508 chr2:239161102 PER2 0.69 7.48 0.38 6.62e-13 Irritable bowel syndrome; LUSC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.6 8.96 0.44 2.25e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10078 0.515 rs1053299 chr5:470760 G/A cg08916839 chr5:415575 AHRR 0.76 7.1 0.36 7.48e-12 Fat distribution (HIV); LUSC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg06363034 chr20:62225388 GMEB2 -0.45 -7.5 -0.38 5.91e-13 Glioblastoma; LUSC cis rs1801251 0.964 rs10933411 chr2:233706847 A/G cg25237894 chr2:233734115 C2orf82 -0.36 -6.81 -0.35 4.67e-11 Coronary artery disease; LUSC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg12963246 chr6:28129442 ZNF389 0.49 6.65 0.34 1.21e-10 Parkinson's disease; LUSC cis rs1568889 1.000 rs7937778 chr11:28104605 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC trans rs2727020 0.514 rs4980444 chr11:49550764 T/A cg15704280 chr7:45808275 SEPT13 -1.06 -20.14 -0.74 1.34e-59 Coronary artery disease; LUSC cis rs9303280 0.901 rs2290400 chr17:38066240 A/G cg19468946 chr17:37922297 IKZF3 -0.39 -6.26 -0.32 1.2e-9 Self-reported allergy; LUSC cis rs3845702 0.733 rs12693217 chr2:180841914 T/G cg01881094 chr2:180872142 CWC22 -1.06 -12.75 -0.57 1.28e-30 Schizophrenia; LUSC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg00310523 chr12:86230176 RASSF9 0.45 8.28 0.41 2.97e-15 Major depressive disorder; LUSC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg00343986 chr7:65444356 GUSB 0.44 6.68 0.34 9.96e-11 Aortic root size; LUSC cis rs3126085 0.935 rs1466757 chr1:152212469 G/A cg26876637 chr1:152193138 HRNR 0.46 6.57 0.34 1.89e-10 Atopic dermatitis; LUSC cis rs12368653 0.584 rs7295422 chr12:58099736 G/A cg15848620 chr12:58087721 OS9 -0.4 -5.68 -0.3 2.99e-8 Multiple sclerosis; LUSC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg24060327 chr5:131705240 SLC22A5 -0.54 -9.05 -0.44 1.2e-17 Breast cancer; LUSC trans rs72674100 0.737 rs2865756 chr4:97992626 C/T cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4443100 0.535 rs13055979 chr22:23474085 C/T cg14186256 chr22:23484241 RTDR1 0.63 8.28 0.41 2.98e-15 Serum parathyroid hormone levels; LUSC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg09085632 chr11:111637200 PPP2R1B 1.0 15.3 0.64 1.97e-40 Primary sclerosing cholangitis; LUSC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg00129232 chr17:37814104 STARD3 -0.45 -6.49 -0.33 3.15e-10 Glomerular filtration rate (creatinine); LUSC cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg02527881 chr3:46936655 PTH1R 0.37 6.57 0.34 1.99e-10 Colorectal cancer; LUSC cis rs4290604 1.000 rs4290604 chr2:238070885 A/G cg23555395 chr2:238036564 NA -0.44 -6.48 -0.33 3.36e-10 Asthma; LUSC cis rs7659604 0.502 rs13104233 chr4:122672473 T/C cg19748678 chr4:122722346 EXOSC9 -0.4 -5.92 -0.31 7.78e-9 Type 2 diabetes; LUSC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -7.57 -0.38 3.6e-13 Developmental language disorder (linguistic errors); LUSC cis rs10426930 0.700 rs10407399 chr19:5009466 A/C cg25246084 chr19:4971487 KDM4B 0.34 6.28 0.32 1.06e-9 Monocyte percentage of white cells; LUSC cis rs2425143 1.000 rs6060643 chr20:34449851 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.9 -0.31 9.06e-9 Blood protein levels; LUSC cis rs6426558 0.515 rs7521110 chr1:227384459 T/A cg10327440 chr1:227177885 CDC42BPA -0.52 -7.08 -0.36 8.4e-12 Neutrophil percentage of white cells; LUSC cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg19628046 chr18:33552617 C18orf21 0.5 5.98 0.31 5.58e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs62400317 0.762 rs10948176 chr6:44833913 A/G cg18551225 chr6:44695536 NA -0.46 -7.46 -0.38 7.6e-13 Total body bone mineral density; LUSC cis rs977987 0.866 rs17696831 chr16:75493298 C/G cg03315344 chr16:75512273 CHST6 0.53 9.97 0.48 1.13e-20 Dupuytren's disease; LUSC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg22029157 chr1:209979665 IRF6 0.51 8.27 0.41 3.33e-15 Monobrow; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg26354017 chr1:205819088 PM20D1 0.91 18.01 0.7 3.64e-51 Menarche (age at onset); LUSC trans rs1941687 0.524 rs6507062 chr18:31374197 G/C cg27147174 chr7:100797783 AP1S1 -0.63 -10.2 -0.49 1.86e-21 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg26446133 chr18:72167187 CNDP2 -0.85 -13.41 -0.59 4.32e-33 Refractive error; LUSC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg17971929 chr21:40555470 PSMG1 0.8 14.24 0.61 2.79e-36 Cognitive function; LUSC cis rs7929679 0.551 rs10836302 chr11:34791897 G/A cg06937548 chr11:34938143 PDHX;APIP 0.4 5.91 0.31 8.29e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg24687543 chr11:63912206 MACROD1 0.44 5.81 0.3 1.45e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg15242686 chr22:24348715 GSTTP1 0.48 7.75 0.39 1.09e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg13206674 chr6:150067644 NUP43 0.58 9.14 0.45 6.43e-18 Lung cancer; LUSC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC cis rs12421382 0.659 rs1866530 chr11:109380899 T/A cg11473876 chr11:109292803 C11orf87 0.39 6.32 0.33 8.41e-10 Schizophrenia; LUSC trans rs6076960 0.684 rs6054049 chr20:6254909 A/G cg21095983 chr6:86352623 SYNCRIP -0.52 -8.27 -0.41 3.31e-15 Smooth-surface caries; LUSC trans rs2694917 0.680 rs1043011 chr12:56865040 G/T cg19051015 chr17:46697414 NA 0.39 6.06 0.31 3.67e-9 Blood metabolite ratios; LUSC cis rs2204008 0.537 rs28680519 chr12:38502946 C/T cg13010199 chr12:38710504 ALG10B 0.64 9.54 0.46 3.17e-19 Bladder cancer; LUSC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg11344533 chr11:111475393 SIK2 0.47 6.6 0.34 1.6e-10 Primary sclerosing cholangitis; LUSC cis rs79220007 1.000 rs79220007 chr6:26098474 T/C cg16482183 chr6:26056742 HIST1H1C 0.99 6.26 0.32 1.19e-9 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg17971929 chr21:40555470 PSMG1 0.79 13.68 0.6 4.05e-34 Cognitive function; LUSC cis rs17818399 0.547 rs4952833 chr2:46762034 T/C cg21681030 chr2:46777652 RHOQ 0.46 6.35 0.33 7.24e-10 Height; LUSC cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg25427524 chr10:38739819 LOC399744 -0.63 -11.3 -0.53 2.68e-25 Extrinsic epigenetic age acceleration; LUSC cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg04455712 chr21:45112962 RRP1B 0.45 8.71 0.43 1.47e-16 Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02899788 chr1:47133675 ATPAF1 0.44 5.95 0.31 6.95e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.19 0.41 5.48e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1113500 0.614 rs61797342 chr1:108608385 G/A cg06207961 chr1:108661230 NA 0.35 5.7 0.3 2.69e-8 Growth-regulated protein alpha levels; LUSC cis rs11190604 0.943 rs11190581 chr10:102243387 T/G cg16342193 chr10:102329863 NA -0.34 -6.21 -0.32 1.59e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg14298792 chr15:30685198 CHRFAM7A 0.51 6.67 0.34 1.04e-10 Huntington's disease progression; LUSC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg05535760 chr7:792225 HEATR2 -0.73 -7.52 -0.38 5.18e-13 Cerebrospinal P-tau181p levels; LUSC cis rs10186029 0.676 rs10932465 chr2:213968389 T/C cg08319019 chr2:214017104 IKZF2 0.6 8.76 0.43 9.95e-17 Systemic sclerosis; LUSC cis rs72781680 0.898 rs72782113 chr2:24024952 G/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg01973587 chr1:228161476 NA 0.47 8.49 0.42 6.91e-16 Diastolic blood pressure; LUSC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg21918786 chr6:109611834 NA -0.4 -6.88 -0.35 2.97e-11 Reticulocyte fraction of red cells; LUSC cis rs7043114 0.525 rs6479419 chr9:95110002 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.72 -0.35 7.86e-11 Height; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg04025307 chr7:1156635 C7orf50 0.46 6.83 0.35 4e-11 Longevity;Endometriosis; LUSC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg26818010 chr10:134567672 INPP5A -0.88 -10.99 -0.52 3.5e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9378688 0.654 rs2479004 chr6:2326765 A/G cg12303981 chr6:2244766 GMDS -0.4 -5.76 -0.3 1.87e-8 Caudate nucleus volume; LUSC cis rs6076065 0.723 rs2051093 chr20:23371349 G/A cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs2652834 0.851 rs12902237 chr15:63418188 C/T cg05507819 chr15:63340323 TPM1 0.45 5.82 0.3 1.4e-8 HDL cholesterol; LUSC cis rs886126 1.000 rs7969686 chr12:111665388 G/A cg10833066 chr12:111807467 FAM109A 0.41 6.54 0.34 2.28e-10 Coronary heart disease; LUSC cis rs6456156 0.586 rs12529876 chr6:167461501 G/A cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC cis rs1670533 1.000 rs6599278 chr4:1058798 C/T cg19318889 chr4:1322082 MAEA 0.45 5.67 0.3 3.09e-8 Recombination rate (females); LUSC cis rs240764 0.817 rs239246 chr6:101089134 G/A cg09795085 chr6:101329169 ASCC3 0.42 6.12 0.32 2.68e-9 Neuroticism; LUSC trans rs853679 1.000 rs853694 chr6:28279100 A/T cg01620082 chr3:125678407 NA -0.57 -6.79 -0.35 5.18e-11 Depression; LUSC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.65 -0.39 2.18e-13 Personality dimensions; LUSC trans rs853679 0.607 rs28360499 chr6:27945396 G/A cg09904177 chr6:26538194 HMGN4 -0.78 -5.94 -0.31 6.98e-9 Depression; LUSC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg17554472 chr22:41940697 POLR3H -0.5 -6.22 -0.32 1.51e-9 Vitiligo; LUSC cis rs10752881 0.839 rs2093983 chr1:183094210 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Colorectal cancer; LUSC cis rs9902453 0.967 rs8067576 chr17:28444254 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.14 0.41 7.79e-15 Coffee consumption (cups per day); LUSC cis rs62103177 0.636 rs9958792 chr18:77627876 T/C cg17174613 chr18:77631625 KCNG2 0.39 5.84 0.3 1.26e-8 Opioid sensitivity; LUSC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg18252515 chr7:66147081 NA -1.21 -13.41 -0.59 4.35e-33 Diabetic kidney disease; LUSC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10266483 0.656 rs670966 chr7:63762899 A/T cg24201672 chr7:64023550 ZNF680 -0.5 -6.6 -0.34 1.63e-10 Response to statin therapy; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg09436375 chr6:42928200 GNMT -0.28 -6.64 -0.34 1.28e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs710216 0.752 rs841849 chr1:43402205 G/A cg22176566 chr1:43424700 SLC2A1 0.48 5.94 0.31 7.3e-9 Red cell distribution width; LUSC cis rs17688076 0.511 rs2418738 chr16:68122604 G/C cg27539214 chr16:67997921 SLC12A4 -0.55 -7.6 -0.38 3.07e-13 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); LUSC cis rs4400599 0.618 rs1194600 chr1:154236009 G/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.9 -0.31 8.84e-9 Platelet distribution width; LUSC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg05340658 chr4:99064831 C4orf37 0.61 10.29 0.49 9.22e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg22105103 chr4:187893119 NA 0.72 14.14 0.61 6.92e-36 Lobe attachment (rater-scored or self-reported); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08422181 chr19:4909468 UHRF1 -0.49 -6.1 -0.32 2.97e-9 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.697 rs45557936 chr20:30226690 G/A cg18721089 chr20:30220636 NA -0.41 -6.85 -0.35 3.62e-11 Mean corpuscular hemoglobin; LUSC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg26441486 chr22:50317300 CRELD2 -0.53 -8.01 -0.4 1.93e-14 Schizophrenia; LUSC cis rs300703 0.654 rs435733 chr2:121222 A/G cg21211680 chr2:198530 NA -0.78 -8.35 -0.42 1.84e-15 Blood protein levels; LUSC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg15448220 chr1:150897856 SETDB1 0.41 6.17 0.32 2.02e-9 Melanoma; LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg11645453 chr3:52864694 ITIH4 0.36 8.22 0.41 4.47e-15 Bipolar disorder; LUSC cis rs6982240 0.514 rs7002268 chr8:142277340 A/G cg00131261 chr8:142287264 NA -0.38 -6.32 -0.33 8.31e-10 Tonsillectomy; LUSC cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg12310025 chr6:25882481 NA -0.35 -5.77 -0.3 1.79e-8 Height; LUSC cis rs2404602 0.622 rs4886506 chr15:77207277 G/T cg23625390 chr15:77176239 SCAPER 0.63 9.86 0.47 2.74e-20 Blood metabolite levels; LUSC cis rs2717559 0.542 rs11774823 chr8:143887568 G/T cg02415014 chr8:143852576 LYNX1 0.34 7.88 0.4 4.74e-14 Urinary tract infection frequency; LUSC cis rs4343996 0.719 rs7803004 chr7:3474084 A/G cg21248987 chr7:3385318 SDK1 0.35 5.78 0.3 1.71e-8 Motion sickness; LUSC cis rs1014246 1.000 rs1014244 chr10:118466150 C/T cg14919929 chr10:118506882 NA 0.38 5.88 0.31 9.98e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg12432903 chr7:1882776 MAD1L1 -0.36 -5.8 -0.3 1.51e-8 Bipolar disorder and schizophrenia; LUSC cis rs950776 0.518 rs56007453 chr15:78826239 T/C cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs4654899 0.743 rs17409373 chr1:21188871 C/A cg01072550 chr1:21505969 NA -0.48 -7.23 -0.37 3.26e-12 Superior frontal gyrus grey matter volume; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27477148 chr19:3360463 NFIC 0.37 6.34 0.33 7.59e-10 Asthma; LUSC cis rs3008870 1.000 rs17497828 chr1:67452322 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.94 -14.73 -0.63 3.35e-38 Lymphocyte percentage of white cells; LUSC trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg17470723 chr8:74884337 TCEB1 0.52 8.19 0.41 5.44e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4930103 0.534 rs2063550 chr11:1979223 G/C cg26856596 chr11:1961893 NA 0.33 6.18 0.32 1.9e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs7937682 0.924 rs501089 chr11:111502479 G/T cg18187862 chr3:45730750 SACM1L -0.56 -6.79 -0.35 5.17e-11 Primary sclerosing cholangitis; LUSC cis rs7202877 0.706 rs8055609 chr16:75402088 C/T cg04384234 chr16:75411784 CFDP1 -0.65 -9.28 -0.45 2.15e-18 Type 2 diabetes;Type 1 diabetes; LUSC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg10755058 chr3:40428713 ENTPD3 0.36 5.93 0.31 7.74e-9 Renal cell carcinoma; LUSC cis rs11785400 0.793 rs9297972 chr8:143723660 C/T cg24634471 chr8:143751801 JRK 0.51 7.21 0.37 3.71e-12 Schizophrenia; LUSC cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg25817165 chr18:72167213 CNDP2 -0.75 -11.17 -0.52 8.07e-25 Refractive error; LUSC cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg05043794 chr9:111880884 C9orf5 -0.34 -7.23 -0.37 3.33e-12 Menarche (age at onset); LUSC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg07636037 chr3:49044803 WDR6 1.03 15.97 0.66 4.58e-43 Parkinson's disease; LUSC cis rs9807989 0.507 rs6726985 chr2:103048580 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.98e-12 Asthma; LUSC cis rs7589342 0.598 rs7602442 chr2:106402795 C/T cg09152813 chr2:106391379 NCK2 0.37 5.8 0.3 1.53e-8 Addiction; LUSC cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg15556689 chr8:8085844 FLJ10661 0.74 11.96 0.55 1.14e-27 Neuroticism; LUSC cis rs9549367 0.713 rs9549352 chr13:113833221 A/G cg00898013 chr13:113819073 PROZ -0.63 -8.81 -0.43 6.9e-17 Platelet distribution width; LUSC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.35 0.49 6.06e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12542260 0.953 rs5004281 chr8:125477134 C/T cg10355837 chr17:64961440 CACNG4 0.44 6.05 0.31 3.8e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.821 rs72796361 chr2:24160689 A/T cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs2286885 1.000 rs10733678 chr9:129242280 G/A cg15282417 chr9:129245246 FAM125B 0.35 5.83 0.3 1.34e-8 Intraocular pressure; LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg22868518 chr11:507468 RNH1 -0.6 -5.98 -0.31 5.74e-9 Body mass index; LUSC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.42 -0.38 9.8e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12712073 0.845 rs1370353 chr2:100764824 G/C cg07810366 chr2:100720526 AFF3 -0.45 -7.68 -0.39 1.83e-13 Intelligence (multi-trait analysis); LUSC cis rs4474465 0.915 rs10899503 chr11:78149961 C/T cg27205649 chr11:78285834 NARS2 -0.51 -6.02 -0.31 4.71e-9 Alzheimer's disease (survival time); LUSC cis rs6489785 0.687 rs3213567 chr12:121222556 T/C cg02419362 chr12:121203948 SPPL3 0.41 7.34 0.37 1.6e-12 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs4853012 0.752 rs13413795 chr2:74349839 G/A cg19729930 chr2:74357872 NA 0.9 16.75 0.68 4.01e-46 Gestational age at birth (maternal effect); LUSC cis rs7647973 0.710 rs1532204 chr3:49609477 C/G cg13072238 chr3:49761600 GMPPB -0.69 -8.19 -0.41 5.44e-15 Menarche (age at onset); LUSC trans rs1325195 0.537 rs2793804 chr1:179201000 C/T cg11624085 chr17:8464688 MYH10 0.43 6.38 0.33 5.94e-10 IgE grass sensitization; LUSC trans rs1998174 0.509 rs10798702 chr1:171815452 A/T cg13482142 chr2:234261155 NA 0.41 6.03 0.31 4.32e-9 Platelet distribution width; LUSC cis rs1784581 0.588 rs7758559 chr6:162438635 G/T cg17173639 chr6:162384350 PARK2 0.53 9.13 0.45 6.52e-18 Itch intensity from mosquito bite; LUSC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg22166914 chr1:53195759 ZYG11B -0.53 -8.56 -0.42 4.13e-16 Monocyte count; LUSC cis rs8099014 1.000 rs7243073 chr18:56130293 A/C cg12907477 chr18:56117327 MIR122 0.42 6.63 0.34 1.38e-10 Platelet count; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg15112475 chr7:1198522 ZFAND2A -0.36 -7.61 -0.38 2.85e-13 Longevity;Endometriosis; LUSC cis rs5769707 0.837 rs1573726 chr22:50032872 G/A cg07959070 chr22:50026188 C22orf34 -0.34 -7.01 -0.36 1.32e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg08219700 chr8:58056026 NA 0.47 5.92 0.31 7.98e-9 Developmental language disorder (linguistic errors); LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.88 0.66 1.08e-42 Platelet count; LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg22920501 chr2:26401640 FAM59B -0.79 -11.76 -0.54 5.97e-27 Gut microbiome composition (summer); LUSC cis rs12421382 0.778 rs12804063 chr11:109495509 C/T cg27471124 chr11:109292789 C11orf87 -0.42 -7.41 -0.38 1.03e-12 Schizophrenia; LUSC cis rs13089785 1.000 rs13071800 chr3:123626813 C/A cg02558132 chr3:123411198 MYLK 0.36 6.22 0.32 1.52e-9 Intelligence (multi-trait analysis); LUSC cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg08999081 chr20:33150536 PIGU -0.41 -7.68 -0.39 1.79e-13 Glomerular filtration rate (creatinine); LUSC cis rs7428 0.527 rs1061782 chr2:85546615 A/G cg24342717 chr2:85555507 TGOLN2 0.74 12.31 0.56 5.7e-29 Ear protrusion; LUSC cis rs6429082 0.689 rs4659923 chr1:235709519 C/T cg26050004 chr1:235667680 B3GALNT2 -0.43 -5.79 -0.3 1.66e-8 Adiposity; LUSC cis rs12950390 0.853 rs59513807 chr17:45867925 G/A cg24803719 chr17:45855879 NA -0.29 -5.67 -0.3 3.12e-8 IgG glycosylation; LUSC cis rs983392 0.805 rs10897011 chr11:59961427 G/A cg24026212 chr11:59952134 MS4A6A -0.38 -6.43 -0.33 4.41e-10 Alzheimer's disease (late onset); LUSC trans rs1728785 1.000 rs698712 chr16:68561879 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.57 0.38 3.58e-13 Ulcerative colitis; LUSC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg24881330 chr22:46731750 TRMU 0.88 8.87 0.44 4.44e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs6469656 0.803 rs4289847 chr8:117683201 C/G cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs2267681 0.583 rs10256282 chr7:139528444 C/T cg14116596 chr7:139528673 TBXAS1 0.36 6.23 0.32 1.42e-9 Cervical cancer; LUSC cis rs9303401 0.659 rs62083368 chr17:56878062 G/A cg25039879 chr17:56429692 SUPT4H1 0.67 9.01 0.44 1.65e-17 Cognitive test performance; LUSC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.37 -6.29 -0.33 9.74e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg08508325 chr11:3079039 CARS -0.52 -12.2 -0.56 1.46e-28 Longevity; LUSC cis rs9921338 0.961 rs7200667 chr16:11440404 C/A cg00044050 chr16:11439710 C16orf75 -0.51 -6.68 -0.34 9.91e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs273573 0.890 rs273606 chr11:30945167 A/T cg14844989 chr11:31128820 NA 0.36 5.76 0.3 1.96e-8 Total body bone mineral density; LUSC cis rs2235649 0.833 rs2011088 chr16:1850091 T/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.07 -0.32 3.44e-9 Blood metabolite levels; LUSC cis rs7582180 0.629 rs11686649 chr2:100946701 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs2425143 1.000 rs2425093 chr20:34306875 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.61 -0.43 2.97e-16 Blood protein levels; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg21782813 chr7:2030301 MAD1L1 0.53 9.27 0.45 2.38e-18 Bipolar disorder and schizophrenia; LUSC cis rs6062509 1.000 rs6062509 chr20:62362563 G/T cg01176363 chr20:62369445 LIME1 -0.46 -6.85 -0.35 3.62e-11 Prostate cancer; LUSC trans rs10435719 0.867 rs6999030 chr8:11795308 G/A cg27411982 chr8:10470053 RP1L1 0.39 6.03 0.31 4.29e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs11112613 0.775 rs12371537 chr12:105971425 T/C cg03607813 chr12:105948248 NA 0.81 11.42 0.53 1.01e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg05802129 chr4:122689817 NA -0.52 -8.67 -0.43 1.96e-16 Type 2 diabetes; LUSC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg17971929 chr21:40555470 PSMG1 0.78 13.53 0.59 1.5e-33 Cognitive function; LUSC cis rs2455601 0.638 rs2742484 chr11:8988083 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.4 -5.94 -0.31 7.28e-9 Schizophrenia; LUSC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg04267008 chr7:1944627 MAD1L1 -0.45 -6.81 -0.35 4.64e-11 Schizophrenia; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg26436829 chr16:86588937 MTHFSD;FLJ30679 0.38 5.94 0.31 7e-9 Schizophrenia; LUSC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg04287289 chr16:89883240 FANCA 0.76 6.26 0.32 1.19e-9 Skin colour saturation; LUSC cis rs7914558 1.000 rs7067970 chr10:104913870 C/T cg05855489 chr10:104503620 C10orf26 0.6 9.7 0.47 9.42e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg08085267 chr17:45401833 C17orf57 -0.51 -8.04 -0.4 1.56e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg05802129 chr4:122689817 NA -0.37 -6.64 -0.34 1.26e-10 Type 2 diabetes; LUSC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg11657440 chr19:46296263 DMWD 0.88 16.75 0.68 3.86e-46 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12963096 chr13:39612675 NHLRC3;C13orf23 0.42 6.51 0.34 2.83e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg17971929 chr21:40555470 PSMG1 -0.8 -14.08 -0.61 1.15e-35 Cognitive function; LUSC cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg15997130 chr1:24165203 NA 0.52 8.61 0.43 2.88e-16 Immature fraction of reticulocytes; LUSC trans rs7824557 0.872 rs6601577 chr8:11102682 C/G cg15556689 chr8:8085844 FLJ10661 0.48 7.56 0.38 3.88e-13 Retinal vascular caliber; LUSC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC trans rs12000445 1.000 rs12000445 chr9:23426271 A/G cg26130488 chr17:59530104 NA -0.44 -6.05 -0.31 3.91e-9 Response to platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg04518342 chr5:131593106 PDLIM4 0.35 6.37 0.33 6.33e-10 Blood metabolite levels; LUSC cis rs6121246 0.529 rs112367115 chr20:30178627 G/A cg18721089 chr20:30220636 NA -0.41 -6.08 -0.32 3.29e-9 Mean corpuscular hemoglobin; LUSC cis rs34779708 0.966 rs12775799 chr10:35488264 C/T cg03585969 chr10:35415529 CREM 0.64 9.53 0.46 3.25e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10876993 0.890 rs1678516 chr12:58047458 G/A cg18357645 chr12:58087776 OS9 0.5 7.49 0.38 6.23e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg05283184 chr6:79620031 NA -0.54 -10.8 -0.51 1.64e-23 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.846 rs1788206 chr8:101306966 A/G cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.35e-15 Atrioventricular conduction; LUSC cis rs2228479 0.681 rs7196840 chr16:89959647 A/G cg06558623 chr16:89946397 TCF25 0.95 10.21 0.49 1.82e-21 Skin colour saturation; LUSC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg07211511 chr3:129823064 LOC729375 -0.62 -8.21 -0.41 4.72e-15 Blood pressure (smoking interaction); LUSC cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg03517284 chr6:25882590 NA 0.43 7.64 0.39 2.36e-13 Blood metabolite levels; LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg09877947 chr5:131593287 PDLIM4 0.48 7.87 0.4 5e-14 Blood metabolite levels; LUSC cis rs6500395 0.890 rs9936271 chr16:48601291 A/G cg04672837 chr16:48644449 N4BP1 0.43 6.31 0.33 8.66e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs34375054 0.525 rs12316499 chr12:125593318 G/A cg25124228 chr12:125621409 AACS -0.57 -9.44 -0.46 6.67e-19 Post bronchodilator FEV1/FVC ratio; LUSC trans rs7681440 0.606 rs2736998 chr4:90754336 A/C cg16902087 chr1:2220497 SKI -0.3 -6.02 -0.31 4.69e-9 Dementia with Lewy bodies; LUSC cis rs6430585 0.527 rs12465544 chr2:136451676 C/T cg07169764 chr2:136633963 MCM6 1.06 14.11 0.61 8.61e-36 Corneal structure; LUSC cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.54 -7.98 -0.4 2.3e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11048434 0.736 rs2377673 chr12:9112551 A/G cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC cis rs17270561 0.723 rs12192635 chr6:25880907 A/T cg16482183 chr6:26056742 HIST1H1C 0.85 11.52 0.53 4.45e-26 Iron status biomarkers; LUSC cis rs529866 0.519 rs4451969 chr16:11383519 A/G cg00044050 chr16:11439710 C16orf75 -0.63 -9.85 -0.47 2.94e-20 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2273669 0.667 rs75675305 chr6:109324353 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs72700829 0.593 rs80350997 chr1:150992010 G/A cg11822372 chr1:151115635 SEMA6C -0.74 -6.77 -0.35 5.98e-11 Schizophrenia; LUSC cis rs7712401 0.623 rs30043 chr5:122272293 G/C cg19077854 chr5:122220652 SNX24 0.42 9.32 0.45 1.68e-18 Mean platelet volume; LUSC cis rs1009647 0.614 rs17253702 chr14:55583883 C/T cg04306507 chr14:55594613 LGALS3 0.43 6.1 0.32 2.89e-9 Testicular germ cell tumor; LUSC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg13072238 chr3:49761600 GMPPB -0.36 -5.84 -0.3 1.23e-8 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg26441486 chr22:50317300 CRELD2 0.48 7.21 0.37 3.88e-12 Schizophrenia; LUSC cis rs78366141 0.649 rs78179026 chr4:89657456 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.93 7.0 0.36 1.37e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg01017244 chr2:74357527 NA 0.67 12.03 0.55 6.03e-28 Gestational age at birth (maternal effect); LUSC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg13206674 chr6:150067644 NUP43 0.53 8.05 0.4 1.44e-14 Lung cancer; LUSC cis rs11583043 0.708 rs11590358 chr1:101560214 C/A cg11406453 chr1:101602562 NA -0.4 -6.69 -0.34 9.45e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4631830 0.932 rs4581397 chr10:51532367 A/G cg20129853 chr10:51489980 NA -0.33 -6.66 -0.34 1.11e-10 Prostate-specific antigen levels; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.65 -10.77 -0.51 2.08e-23 Lymphocyte counts; LUSC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg02807482 chr3:125708958 NA -0.52 -7.02 -0.36 1.28e-11 Blood pressure (smoking interaction); LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg23978390 chr7:1156363 C7orf50 0.44 6.31 0.33 8.65e-10 Longevity;Endometriosis; LUSC cis rs2637266 1.000 rs2637267 chr10:78331803 A/G cg18941641 chr10:78392320 NA 0.37 6.58 0.34 1.83e-10 Pulmonary function; LUSC cis rs17373728 0.710 rs2221810 chr8:76221468 C/G cg07016329 chr8:76221503 NA -0.48 -6.96 -0.36 1.86e-11 Diabetic kidney disease; LUSC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.52 7.86 0.39 5.5e-14 Eosinophil percentage of white cells; LUSC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg03806693 chr22:41940476 POLR3H -0.87 -12.62 -0.57 3.99e-30 Vitiligo; LUSC cis rs8062405 0.755 rs7193402 chr16:28586127 A/G cg16576597 chr16:28551801 NUPR1 0.34 6.91 0.35 2.46e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4343996 0.558 rs10273728 chr7:3414854 A/G cg21248987 chr7:3385318 SDK1 0.34 5.71 0.3 2.44e-8 Motion sickness; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.95 0.44 2.52e-17 Prudent dietary pattern; LUSC cis rs7917772 0.512 rs11594073 chr10:104308193 T/C cg05855489 chr10:104503620 C10orf26 0.48 7.35 0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs4356932 0.967 rs9999755 chr4:76961802 G/A cg00809888 chr4:76862425 NAAA 0.36 5.92 0.31 7.79e-9 Blood protein levels; LUSC cis rs7592578 0.766 rs12472081 chr2:191398545 G/A cg10560079 chr2:191398806 TMEM194B -0.71 -7.95 -0.4 2.98e-14 Diastolic blood pressure; LUSC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg25319279 chr11:5960081 NA 0.44 6.37 0.33 6.19e-10 DNA methylation (variation); LUSC cis rs17270561 0.666 rs4712976 chr6:25842203 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 7.18 0.37 4.57e-12 Iron status biomarkers; LUSC cis rs765787 0.530 rs12442533 chr15:45529631 G/C cg24006582 chr15:45444508 DUOX1 0.66 9.48 0.46 4.73e-19 Uric acid levels; LUSC cis rs1775715 0.707 rs2808094 chr10:32133756 T/C cg18675610 chr10:32216311 ARHGAP12 0.31 6.75 0.35 6.67e-11 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs8072100 0.905 rs9901869 chr17:45575206 G/A cg03886242 chr7:26192032 NFE2L3 -0.38 -6.23 -0.32 1.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs10090774 0.965 rs11785430 chr8:142009527 A/G cg10310310 chr7:157367150 PTPRN2;MIR153-2 0.29 6.11 0.32 2.72e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg04369109 chr6:150039330 LATS1 0.53 7.67 0.39 1.92e-13 Lung cancer; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg15112475 chr7:1198522 ZFAND2A -0.3 -6.23 -0.32 1.38e-9 Longevity;Endometriosis; LUSC cis rs7408868 1.000 rs7247906 chr19:15271135 T/G cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.1e-18 Pulse pressure; LUSC cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.32 -0.41 2.21e-15 Schizophrenia; LUSC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg24399712 chr22:39784796 NA 0.62 10.7 0.51 3.59e-23 Intelligence (multi-trait analysis); LUSC cis rs2219968 0.923 rs11779013 chr8:78930177 T/C cg00738934 chr8:78996279 NA 0.39 7.1 0.36 7.4e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4654899 0.629 rs2320590 chr1:21155195 C/T cg01072550 chr1:21505969 NA 0.42 6.42 0.33 4.81e-10 Superior frontal gyrus grey matter volume; LUSC cis rs4343996 0.701 rs4722709 chr7:3388206 G/A cg21248987 chr7:3385318 SDK1 -0.36 -6.04 -0.31 4.08e-9 Motion sickness; LUSC cis rs4731207 0.741 rs1557969 chr7:124405738 A/G cg14311320 chr7:124405732 GPR37 0.32 6.18 0.32 1.84e-9 Cutaneous malignant melanoma; LUSC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg13939156 chr17:80058883 NA -0.33 -6.6 -0.34 1.59e-10 Life satisfaction; LUSC cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg05555928 chr11:63887634 MACROD1 -0.46 -6.08 -0.32 3.36e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6088580 0.524 rs6088575 chr20:33273403 C/T cg08999081 chr20:33150536 PIGU 0.36 6.51 0.34 2.82e-10 Glomerular filtration rate (creatinine); LUSC trans rs2797160 0.874 rs58305111 chr6:126008386 G/T cg05039488 chr6:79577232 IRAK1BP1 0.47 6.99 0.36 1.53e-11 Endometrial cancer; LUSC cis rs12541635 0.966 rs6469023 chr8:106989558 T/C cg10147462 chr8:107024639 NA 0.56 9.86 0.47 2.76e-20 Age of smoking initiation; LUSC trans rs236907 0.812 rs17657363 chr1:171801416 C/T cg13482142 chr2:234261155 NA -0.51 -6.32 -0.33 8.52e-10 Mean platelet volume; LUSC cis rs11098499 0.954 rs9998585 chr4:120396802 T/A cg09307838 chr4:120376055 NA 0.79 11.65 0.54 1.5e-26 Corneal astigmatism; LUSC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg14558114 chr2:88469736 THNSL2 0.8 7.13 0.36 6.19e-12 Plasma clusterin levels; LUSC trans rs2262909 0.962 rs401424 chr19:22232023 A/G cg17074339 chr11:11642133 GALNTL4 -0.4 -6.13 -0.32 2.53e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4727027 0.704 rs7784122 chr7:148904624 A/G cg23158103 chr7:148848205 ZNF398 0.5 8.6 0.43 3.06e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg08999081 chr20:33150536 PIGU 0.44 8.15 0.41 7.3e-15 Coronary artery disease; LUSC cis rs6494488 0.500 rs55990268 chr15:64854304 A/G cg08069370 chr15:64387884 SNX1 -0.64 -5.73 -0.3 2.24e-8 Coronary artery disease; LUSC cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg18252515 chr7:66147081 NA -1.13 -12.82 -0.57 7.23e-31 Diabetic kidney disease; LUSC cis rs2289583 0.642 rs8034281 chr15:75384227 A/G cg10253484 chr15:75165896 SCAMP2 -0.4 -5.7 -0.3 2.63e-8 Systemic lupus erythematosus; LUSC cis rs240764 0.817 rs6938440 chr6:101152009 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.17 -0.32 2.03e-9 Neuroticism; LUSC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg00310523 chr12:86230176 RASSF9 0.44 7.85 0.39 5.84e-14 Major depressive disorder; LUSC cis rs9905704 0.647 rs9901655 chr17:56987142 G/A cg12560992 chr17:57184187 TRIM37 0.6 9.77 0.47 5.35e-20 Testicular germ cell tumor; LUSC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.56 7.76 0.39 1.06e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8078723 0.738 rs4065321 chr17:38143548 C/T cg17467752 chr17:38218738 THRA -0.71 -11.39 -0.53 1.31e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs1994135 0.669 rs10844629 chr12:33697096 T/A cg13010199 chr12:38710504 ALG10B 0.48 6.62 0.34 1.39e-10 Resting heart rate; LUSC cis rs2130392 0.926 rs4610379 chr4:185624388 A/G cg04058563 chr4:185651563 MLF1IP 0.41 6.58 0.34 1.84e-10 Kawasaki disease; LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg16325326 chr1:53192061 ZYG11B -0.81 -14.54 -0.62 1.97e-37 Monocyte count; LUSC cis rs7432375 0.641 rs835649 chr3:136671890 G/A cg15507776 chr3:136538369 TMEM22 0.44 7.27 0.37 2.53e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg21862992 chr11:68658383 NA 0.52 8.03 0.4 1.64e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs8017423 0.935 rs2104704 chr14:90696609 A/G cg04374321 chr14:90722782 PSMC1 -0.69 -10.4 -0.49 3.84e-22 Mortality in heart failure; LUSC cis rs854765 0.594 rs8066560 chr17:17728043 A/G cg16928487 chr17:17741425 SREBF1 0.46 9.06 0.44 1.1e-17 Total body bone mineral density; LUSC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg12310025 chr6:25882481 NA 0.42 6.9 0.35 2.57e-11 Intelligence (multi-trait analysis); LUSC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg16235748 chr6:149772707 ZC3H12D -0.32 -6.47 -0.33 3.42e-10 Dupuytren's disease; LUSC cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -11.08 -0.52 1.68e-24 Chronic sinus infection; LUSC trans rs7944735 0.938 rs59185955 chr11:47961566 G/C cg15704280 chr7:45808275 SEPT13 0.63 6.57 0.34 1.98e-10 Intraocular pressure; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg06263672 chr7:65235340 NA -0.4 -5.8 -0.3 1.5e-8 Calcium levels; LUSC trans rs12579753 0.913 rs17749243 chr12:82178079 A/C cg07923666 chr12:49932857 KCNH3 -0.5 -6.25 -0.32 1.28e-9 Resting heart rate; LUSC cis rs7705502 0.962 rs55850761 chr5:173373488 A/C cg18693985 chr5:173351052 CPEB4 -0.37 -5.87 -0.31 1.06e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs826838 1.000 rs851934 chr12:39104453 G/T cg13010199 chr12:38710504 ALG10B -0.62 -10.53 -0.5 1.44e-22 Heart rate; LUSC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg14552801 chr7:65878734 NA -0.46 -6.54 -0.34 2.37e-10 Aortic root size; LUSC cis rs9388451 0.874 rs9398787 chr6:126090608 A/G cg10911889 chr6:126070802 HEY2 0.43 6.63 0.34 1.38e-10 Brugada syndrome; LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg25072359 chr17:41440525 NA 0.66 9.5 0.46 4.09e-19 Menopause (age at onset); LUSC trans rs12579753 0.871 rs35801863 chr12:82238818 A/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg27631724 chr1:11040367 C1orf127 0.51 9.05 0.44 1.23e-17 Ewing sarcoma; LUSC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.52 -7.38 -0.37 1.27e-12 Tuberculosis; LUSC cis rs96067 0.805 rs2231317 chr1:36603290 C/T cg24686825 chr1:36642396 MAP7D1 -0.43 -6.03 -0.31 4.28e-9 Corneal structure; LUSC cis rs11971779 0.680 rs2355786 chr7:139065622 A/C cg23387468 chr7:139079360 LUC7L2 -0.41 -6.18 -0.32 1.88e-9 Diisocyanate-induced asthma; LUSC cis rs7727544 0.570 rs7701237 chr5:131534381 C/T cg14196790 chr5:131705035 SLC22A5 0.45 7.57 0.38 3.68e-13 Blood metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23296058 chr5:86708877 CCNH -0.36 -5.95 -0.31 6.81e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.82e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg07507251 chr3:52567010 NT5DC2 0.38 7.59 0.38 3.18e-13 Electroencephalogram traits; LUSC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.47 -7.58 -0.38 3.33e-13 Alzheimer's disease (late onset); LUSC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.79 0.63 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs763014 1.000 rs763014 chr16:675680 T/C cg09263875 chr16:632152 PIGQ 0.71 13.09 0.58 6.8e-32 Height; LUSC cis rs2011503 0.883 rs17216041 chr19:19366643 C/T cg11244672 chr19:19639970 YJEFN3 -0.49 -6.08 -0.32 3.25e-9 Bipolar disorder; LUSC cis rs9902453 0.872 rs34698290 chr17:28500465 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.23 0.41 4.2e-15 Coffee consumption (cups per day); LUSC cis rs559928 1.000 rs471584 chr11:64149252 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.6 -6.36 -0.33 6.76e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs951366 0.539 rs1935025 chr1:205692084 C/A cg07157834 chr1:205819609 PM20D1 -0.44 -5.83 -0.3 1.33e-8 Menarche (age at onset); LUSC cis rs4363385 0.818 rs1334850 chr1:153004519 G/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.23 -0.37 3.4e-12 Inflammatory skin disease; LUSC cis rs8060686 0.545 rs12444188 chr16:68282077 G/A cg27539214 chr16:67997921 SLC12A4 -0.59 -7.0 -0.36 1.39e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg21132104 chr15:45694354 SPATA5L1 0.55 7.81 0.39 7.71e-14 Homoarginine levels; LUSC trans rs853679 0.607 rs66868086 chr6:27865902 A/T cg01620082 chr3:125678407 NA -0.83 -7.16 -0.36 5.24e-12 Depression; LUSC cis rs11190604 1.000 rs7099913 chr10:102314777 T/C cg07080220 chr10:102295463 HIF1AN 0.65 8.57 0.42 3.96e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9311676 0.656 rs7620012 chr3:58373716 G/A cg13750441 chr3:58318267 PXK 0.36 6.93 0.35 2.12e-11 Systemic lupus erythematosus; LUSC cis rs1790761 0.667 rs658768 chr11:67337808 G/A cg14500267 chr11:67383377 NA 0.34 6.51 0.34 2.75e-10 Mean corpuscular volume; LUSC cis rs72772090 0.539 rs72773947 chr5:96125533 T/A cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.96 -0.36 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg05425664 chr17:57184151 TRIM37 -0.56 -8.22 -0.41 4.62e-15 Intelligence (multi-trait analysis); LUSC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg08439880 chr3:133502540 NA -0.34 -6.07 -0.32 3.48e-9 Iron status biomarkers; LUSC cis rs4499344 0.696 rs2868154 chr19:33099305 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.85 12.92 0.58 3.09e-31 Mean platelet volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00914462 chr1:245027772 HNRNPU -0.41 -6.18 -0.32 1.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg15423357 chr2:25149977 NA 0.42 8.41 0.42 1.17e-15 Body mass index; LUSC cis rs9807989 0.507 rs6706002 chr2:103006104 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.29e-12 Asthma; LUSC cis rs7246967 0.673 rs35731237 chr19:22820510 G/T cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC trans rs4800353 0.929 rs7243005 chr18:19612287 A/C cg01841828 chr16:69166849 CHTF8;CIRH1A -0.55 -5.95 -0.31 6.73e-9 Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6733011 0.560 rs7579189 chr2:99464718 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.45 -6.38 -0.33 5.77e-10 Bipolar disorder; LUSC trans rs7824557 1.000 rs2736371 chr8:11105529 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.46 -0.33 3.73e-10 Retinal vascular caliber; LUSC trans rs11098499 0.775 rs67281037 chr4:120281157 G/C cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs28493229 0.708 rs4803352 chr19:41159193 C/T cg21869046 chr19:41225005 ITPKC -0.4 -5.79 -0.3 1.66e-8 Kawasaki disease; LUSC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg16386425 chr10:429943 DIP2C -0.37 -5.85 -0.31 1.14e-8 Psychosis in Alzheimer's disease; LUSC trans rs9650657 0.504 rs10109167 chr8:11033525 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.74 -0.39 1.17e-13 Neuroticism; LUSC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg09323728 chr8:95962352 TP53INP1 -0.42 -8.81 -0.43 7.18e-17 Type 2 diabetes; LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 12.32 0.56 5.15e-29 Platelet count; LUSC cis rs7178572 0.633 rs7162637 chr15:77843365 A/G cg22256960 chr15:77711686 NA -0.47 -6.92 -0.35 2.35e-11 Type 2 diabetes; LUSC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg08048268 chr3:133502702 NA -0.4 -7.31 -0.37 2.03e-12 Iron status biomarkers; LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.24 0.32 1.33e-9 Menopause (age at onset); LUSC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC cis rs7095944 0.613 rs11245366 chr10:126482849 C/T cg08799069 chr10:126477246 METTL10 -0.43 -6.57 -0.34 1.97e-10 Asthma; LUSC cis rs1371867 0.810 rs1692004 chr8:101247320 T/C cg06002616 chr8:101225028 SPAG1 0.45 7.37 0.37 1.39e-12 Atrioventricular conduction; LUSC cis rs1153858 1.000 rs1145074 chr15:45703824 T/A cg26924012 chr15:45694286 SPATA5L1 1.09 18.53 0.71 3.27e-53 Homoarginine levels; LUSC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg03264133 chr6:25882463 NA -0.56 -9.19 -0.45 4.31e-18 Intelligence (multi-trait analysis); LUSC cis rs2315504 1.000 rs2315504 chr17:39046881 A/C cg17985300 chr17:38952333 KRT28 0.35 7.36 0.37 1.4e-12 Height; LUSC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg27121462 chr16:89883253 FANCA 0.55 8.89 0.44 3.93e-17 Vitiligo; LUSC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg25173405 chr17:45401733 C17orf57 -0.38 -5.66 -0.3 3.3e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1018836 0.884 rs7008765 chr8:91632589 C/T cg16814680 chr8:91681699 NA -0.76 -12.73 -0.57 1.56e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg18302933 chr2:88491318 NA -0.39 -7.57 -0.38 3.66e-13 Response to metformin (IC50); LUSC trans rs62238980 0.614 rs77886759 chr22:32390956 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs796825 0.530 rs1907683 chr3:119950617 A/C cg21790991 chr3:120137480 FSTL1 -0.33 -6.04 -0.31 4.05e-9 HIV-1 susceptibility; LUSC cis rs965469 0.724 rs2007022 chr20:3237674 C/A cg25506879 chr20:3388711 C20orf194 -0.49 -5.67 -0.3 3.17e-8 IFN-related cytopenia; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13732083 chr21:47605072 C21orf56 0.41 5.93 0.31 7.77e-9 Testicular germ cell tumor; LUSC cis rs7615952 0.932 rs7629977 chr3:125649573 T/G cg05084668 chr3:125655381 ALG1L -0.79 -11.57 -0.54 2.84e-26 Blood pressure (smoking interaction); LUSC cis rs9902453 0.791 rs6505141 chr17:27998187 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.19 0.52 6.75e-25 Coffee consumption (cups per day); LUSC cis rs11608355 0.545 rs11613021 chr12:109897998 T/G cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC trans rs7829975 0.502 rs7820738 chr8:8702607 C/G cg21775007 chr8:11205619 TDH -0.44 -6.28 -0.32 1.04e-9 Mood instability; LUSC cis rs9303401 0.646 rs7342863 chr17:57227010 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.45 6.72 0.34 7.98e-11 Cognitive test performance; LUSC cis rs651907 0.514 rs34301719 chr3:101417993 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 7.88 0.4 4.67e-14 Colorectal cancer; LUSC cis rs7772486 0.875 rs2748497 chr6:146319417 C/T cg23711669 chr6:146136114 FBXO30 0.84 14.9 0.63 7.77e-39 Lobe attachment (rater-scored or self-reported); LUSC trans rs2269241 0.636 rs61765292 chr1:64113459 A/G cg15664323 chr6:4427110 NA 0.35 5.96 0.31 6.41e-9 Type 1 diabetes; LUSC cis rs16867321 0.694 rs4666853 chr2:181439671 C/T cg23363182 chr2:181467187 NA 0.57 9.27 0.45 2.34e-18 Obesity; LUSC cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg21665744 chr7:39171113 POU6F2 0.43 6.55 0.34 2.2e-10 IgG glycosylation; LUSC cis rs13315871 0.858 rs13090428 chr3:58314412 A/G cg12435725 chr3:58293450 RPP14 -0.72 -7.38 -0.37 1.3e-12 Cholesterol, total; LUSC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg08219700 chr8:58056026 NA 0.64 8.1 0.41 1.03e-14 Developmental language disorder (linguistic errors); LUSC cis rs10789491 1.000 rs11211342 chr1:47163098 T/C cg15501359 chr1:47185051 KIAA0494 0.81 11.47 0.53 6.7e-26 Response to hepatitis C treatment; LUSC cis rs12477438 0.765 rs13390672 chr2:99589829 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.68 -0.57 2.41e-30 Chronic sinus infection; LUSC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg06481639 chr22:41940642 POLR3H -0.49 -5.71 -0.3 2.55e-8 Vitiligo; LUSC cis rs9902453 1.000 rs7221743 chr17:28407876 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.59 -0.43 3.42e-16 Coffee consumption (cups per day); LUSC cis rs11190604 1.000 rs2495758 chr10:102321900 C/G cg16342193 chr10:102329863 NA -0.4 -6.51 -0.34 2.75e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg05585544 chr11:47624801 NA -0.4 -7.02 -0.36 1.28e-11 Subjective well-being; LUSC cis rs4319547 0.614 rs10846764 chr12:122874297 T/C cg23029597 chr12:123009494 RSRC2 0.75 9.48 0.46 5.05e-19 Body mass index; LUSC trans rs7824557 0.767 rs4559208 chr8:11153925 C/G cg15556689 chr8:8085844 FLJ10661 0.54 8.44 0.42 9.84e-16 Retinal vascular caliber; LUSC trans rs7937682 0.889 rs516263 chr11:111484719 A/C cg18187862 chr3:45730750 SACM1L 0.52 6.83 0.35 4e-11 Primary sclerosing cholangitis; LUSC cis rs10743315 0.557 rs17505005 chr12:19296294 C/T cg02471346 chr12:19282374 PLEKHA5 0.76 6.23 0.32 1.36e-9 Gut microbiota (bacterial taxa); LUSC cis rs7799006 0.929 rs7781856 chr7:2257199 C/T cg08027265 chr7:2291960 NA -0.42 -7.02 -0.36 1.23e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10761482 0.813 rs4948402 chr10:62107452 T/C cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg20283391 chr11:68216788 NA -0.51 -7.39 -0.37 1.17e-12 Total body bone mineral density; LUSC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -6.65 -0.34 1.17e-10 Total body bone mineral density; LUSC cis rs1371867 0.875 rs1788169 chr8:101326314 C/T cg00191853 chr8:101177733 SPAG1 -0.4 -6.42 -0.33 4.77e-10 Atrioventricular conduction; LUSC cis rs9325144 0.510 rs6582599 chr12:38715965 T/G cg13010199 chr12:38710504 ALG10B 0.46 7.15 0.36 5.43e-12 Morning vs. evening chronotype; LUSC cis rs4595586 0.563 rs11169769 chr12:39233134 C/G cg13010199 chr12:38710504 ALG10B 0.63 9.3 0.45 1.84e-18 Morning vs. evening chronotype; LUSC cis rs9457247 0.967 rs387733 chr6:167409771 C/T cg07741184 chr6:167504864 NA -0.38 -6.97 -0.36 1.75e-11 Crohn's disease; LUSC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg08859206 chr1:53392774 SCP2 0.52 9.03 0.44 1.39e-17 Monocyte count; LUSC cis rs654950 0.934 rs654220 chr1:42002556 A/T cg06885757 chr1:42089581 HIVEP3 -0.43 -8.07 -0.4 1.26e-14 Airway imaging phenotypes; LUSC cis rs847577 0.506 rs7808528 chr7:97721425 G/T cg24562669 chr7:97807699 LMTK2 0.47 8.27 0.41 3.2e-15 Breast cancer; LUSC cis rs1577917 0.655 rs9342045 chr6:86425148 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 7.3 0.37 2.1e-12 Response to antipsychotic treatment; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16203330 chr2:65658524 SPRED2 -0.41 -6.12 -0.32 2.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9486719 1.000 rs2205755 chr6:96864704 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs1577917 1.000 rs2324843 chr6:86617501 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.29 0.33 9.92e-10 Menopause (age at onset); LUSC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg11941060 chr3:133502564 NA -0.53 -8.17 -0.41 6.64e-15 Iron status biomarkers; LUSC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg14830002 chr1:247616686 OR2B11 0.51 7.0 0.36 1.42e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg06145435 chr7:1022769 CYP2W1 0.29 6.11 0.32 2.74e-9 Longevity;Endometriosis; LUSC cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.69 -0.34 9.14e-11 Monocyte percentage of white cells; LUSC trans rs12476592 0.602 rs2028887 chr2:63716223 A/G cg11186405 chr13:112728206 NA -0.37 -5.94 -0.31 7.06e-9 Childhood ear infection; LUSC cis rs950027 0.620 rs1153862 chr15:45631868 A/G cg21132104 chr15:45694354 SPATA5L1 0.41 6.02 0.31 4.69e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs6598955 0.614 rs1134584 chr1:26608828 G/A cg04990556 chr1:26633338 UBXN11 -0.78 -14.42 -0.62 5.7e-37 Obesity-related traits; LUSC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs9311676 0.632 rs11130643 chr3:58423288 G/A cg26110898 chr3:58419937 PDHB 0.39 6.42 0.33 4.71e-10 Systemic lupus erythematosus; LUSC trans rs2487048 0.725 rs2246293 chr9:107690838 C/G cg17444859 chr7:41543664 NA -0.26 -6.18 -0.32 1.88e-9 Intraocular pressure; LUSC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg26408565 chr15:76604113 ETFA -0.52 -8.3 -0.41 2.62e-15 Blood metabolite levels; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg19725989 chr11:67007604 KDM2A 0.49 6.04 0.31 4.2e-9 Allergic disease (asthma, hay fever or eczema); LUSC trans rs561341 1.000 rs546748 chr17:30324293 A/C cg27661571 chr11:113659931 NA -0.55 -6.73 -0.35 7.54e-11 Hip circumference adjusted for BMI; LUSC cis rs9303401 0.659 rs72828726 chr17:56951217 C/G cg25039879 chr17:56429692 SUPT4H1 0.68 9.03 0.44 1.41e-17 Cognitive test performance; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25220428 chr6:19144084 NA 0.48 6.06 0.31 3.61e-9 Bipolar disorder and schizophrenia; LUSC cis rs7178572 0.524 rs7163503 chr15:77493505 C/A cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg06221963 chr1:154839813 KCNN3 -0.61 -13.87 -0.6 7.21e-35 Prostate cancer; LUSC cis rs1801251 1.000 rs3816334 chr2:233708806 A/G cg08000102 chr2:233561755 GIGYF2 -0.69 -11.5 -0.53 5.13e-26 Coronary artery disease; LUSC cis rs4680 0.737 rs6269 chr22:19949952 A/G cg06346307 chr22:19949965 COMT -0.35 -7.2 -0.37 3.91e-12 Blood metabolite levels; LUSC trans rs7951105 1.000 rs1906682 chr11:39254780 A/G cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.64e-9 Free thyroxine concentration; LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg22920501 chr2:26401640 FAM59B 0.81 12.01 0.55 7.35e-28 Gut microbiome composition (summer); LUSC cis rs734999 0.588 rs2764841 chr1:2529360 G/A cg18854424 chr1:2615690 NA -0.52 -10.6 -0.5 8.29e-23 Ulcerative colitis; LUSC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg01191920 chr7:158217561 PTPRN2 -0.58 -12.14 -0.55 2.36e-28 Obesity-related traits; LUSC cis rs10208940 0.764 rs6741037 chr2:68787042 C/T cg12452813 chr2:68675892 NA 0.57 5.92 0.31 7.99e-9 Urate levels in lean individuals; LUSC cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg05283184 chr6:79620031 NA -0.57 -12.18 -0.55 1.73e-28 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.49 -7.26 -0.37 2.68e-12 Renal function-related traits (BUN); LUSC cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg27129171 chr3:47204927 SETD2 -0.65 -10.49 -0.5 1.91e-22 Colorectal cancer; LUSC cis rs2290405 0.527 rs6829987 chr4:932974 C/G cg04824913 chr4:887549 GAK -0.72 -9.9 -0.48 2e-20 Systemic sclerosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23732384 chr19:7968566 MAP2K7 -0.39 -5.95 -0.31 6.75e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9388451 1.000 rs9388451 chr6:126090377 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -9.02 -0.44 1.46e-17 Brugada syndrome; LUSC cis rs977987 0.806 rs11865004 chr16:75395777 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.95 -0.36 1.94e-11 Dupuytren's disease; LUSC cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg22906224 chr7:99728672 NA 0.6 8.89 0.44 3.91e-17 Coronary artery disease; LUSC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg13607699 chr17:42295918 UBTF -0.47 -7.52 -0.38 5.14e-13 Total body bone mineral density; LUSC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC cis rs10197940 0.789 rs2444256 chr2:152280365 C/T cg19508488 chr2:152266495 RIF1 0.46 6.65 0.34 1.2e-10 Lung cancer; LUSC cis rs9815354 0.638 rs56194645 chr3:41843593 T/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg08859206 chr1:53392774 SCP2 -0.5 -8.66 -0.43 2.02e-16 Monocyte count; LUSC cis rs9467773 1.000 rs9467787 chr6:26556769 G/T cg11502198 chr6:26597334 ABT1 0.63 9.95 0.48 1.31e-20 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.64 -0.47 1.42e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs9790314 1.000 rs336543 chr3:161061080 C/T cg03342759 chr3:160939853 NMD3 0.47 7.84 0.39 6.12e-14 Morning vs. evening chronotype; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg20829379 chr3:45838083 SLC6A20 0.36 6.07 0.32 3.44e-9 Metabolite levels (Pyroglutamine); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08984023 chr10:64133896 ZNF365 -0.49 -6.36 -0.33 6.6e-10 Bipolar disorder and schizophrenia; LUSC cis rs6696846 0.749 rs7553876 chr1:205079915 A/G cg00857998 chr1:205179979 DSTYK 0.61 9.85 0.47 2.83e-20 Red blood cell count; LUSC cis rs7246967 0.673 rs9677019 chr19:22912659 T/C cg23217946 chr19:22817039 ZNF492 0.46 6.22 0.32 1.48e-9 Bronchopulmonary dysplasia; LUSC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg18876405 chr7:65276391 NA -0.55 -8.56 -0.42 4.3e-16 Aortic root size; LUSC cis rs6967385 0.560 rs4301352 chr7:12356481 T/G cg20607287 chr7:12443886 VWDE 0.51 7.63 0.39 2.52e-13 Response to taxane treatment (placlitaxel); LUSC cis rs35264875 0.851 rs72930631 chr11:68867835 T/C cg02660097 chr11:68866761 NA 0.42 6.44 0.33 4.18e-10 Blond vs. brown hair color; LUSC cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg05347473 chr6:146136440 FBXO30 -0.49 -8.29 -0.41 2.87e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9283706 0.623 rs10041624 chr5:66314861 T/A cg11590213 chr5:66331682 MAST4 0.43 6.29 0.33 9.67e-10 Coronary artery disease; LUSC cis rs17014483 0.822 rs3017895 chr4:89649491 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 -0.58 -5.69 -0.3 2.83e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9467773 0.572 rs13213953 chr6:26594534 T/A cg11502198 chr6:26597334 ABT1 0.68 10.7 0.51 3.65e-23 Intelligence (multi-trait analysis); LUSC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg05754148 chr16:3507555 NAT15 -0.83 -8.87 -0.44 4.51e-17 Tuberculosis; LUSC cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg22681709 chr2:178499509 PDE11A 0.49 7.01 0.36 1.32e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg13256891 chr4:100009986 ADH5 0.52 6.95 0.36 1.88e-11 Smoking initiation; LUSC cis rs4803468 0.935 rs12602 chr19:41889748 T/C cg09537434 chr19:41945824 ATP5SL -0.89 -15.31 -0.64 1.87e-40 Height; LUSC cis rs28829049 0.536 rs2073106 chr1:19549343 G/C cg13387374 chr1:19411106 UBR4 0.44 5.69 0.3 2.85e-8 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7107174 1.000 rs10899479 chr11:78052539 A/G cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27223758 chr11:64491106 NRXN2 -0.51 -6.14 -0.32 2.32e-9 Bipolar disorder and schizophrenia; LUSC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg22496339 chr2:162101262 NA 0.73 11.88 0.54 2.23e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg12011299 chr4:100065546 ADH4 0.73 12.14 0.55 2.45e-28 Alcohol dependence; LUSC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg05776053 chr2:74358815 NA 0.45 7.19 0.37 4.38e-12 Gestational age at birth (maternal effect); LUSC trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg03929089 chr4:120376271 NA -0.86 -12.04 -0.55 5.53e-28 Height; LUSC cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg26061582 chr7:22766209 IL6 0.42 6.25 0.32 1.26e-9 Lung cancer; LUSC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg21770322 chr7:97807741 LMTK2 0.4 6.99 0.36 1.47e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg15704280 chr7:45808275 SEPT13 -0.83 -11.71 -0.54 8.72e-27 Coronary artery disease; LUSC cis rs12543645 0.598 rs17767186 chr8:10277494 C/T cg12940923 chr8:10282607 MSRA 0.38 6.85 0.35 3.62e-11 Schizophrenia; LUSC cis rs2486288 0.656 rs8041702 chr15:45547093 C/T cg26924012 chr15:45694286 SPATA5L1 -0.69 -10.07 -0.48 5.42e-21 Glomerular filtration rate; LUSC cis rs13217239 0.608 rs6930508 chr6:27053142 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.31 -6.07 -0.31 3.57e-9 Schizophrenia; LUSC trans rs1325195 0.920 rs411266 chr1:179224861 A/G cg11624085 chr17:8464688 MYH10 0.43 6.92 0.35 2.28e-11 IgE grass sensitization; LUSC cis rs9473147 0.798 rs4711895 chr6:47627027 C/T cg12968598 chr6:47444699 CD2AP -0.37 -5.75 -0.3 2.01e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg12257692 chr3:49977190 RBM6 -0.25 -6.95 -0.36 1.96e-11 Body mass index; LUSC cis rs9356171 0.539 rs11755754 chr6:164325492 A/G cg25752492 chr6:164341247 NA -0.39 -6.68 -0.34 9.82e-11 Diisocyanate-induced asthma; LUSC cis rs7945705 0.776 rs2316865 chr11:8815470 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.57 11.02 0.52 2.7e-24 Hemoglobin concentration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19963747 chr17:79633496 C17orf90;CCDC137 -0.45 -6.79 -0.35 5.1e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2404602 0.532 rs206205 chr15:76736091 T/G cg23625390 chr15:77176239 SCAPER 0.55 8.65 0.43 2.26e-16 Blood metabolite levels; LUSC cis rs7100689 0.646 rs10736347 chr10:82134465 G/A cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs7666738 0.546 rs62320963 chr4:98839297 A/G cg03676636 chr4:99064102 C4orf37 0.33 6.42 0.33 4.7e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs6456156 0.586 rs7762156 chr6:167485831 A/T cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10944437 chr8:56686135 TMEM68;TGS1 -0.4 -5.96 -0.31 6.36e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg00745463 chr17:30367425 LRRC37B -0.78 -9.0 -0.44 1.7e-17 Hip circumference adjusted for BMI; LUSC cis rs1577917 1.000 rs6923148 chr6:86767786 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.43 6.33 0.33 7.72e-10 Response to antipsychotic treatment; LUSC cis rs3617 0.573 rs12638968 chr3:52919447 T/A cg11645453 chr3:52864694 ITIH4 -0.38 -8.69 -0.43 1.68e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.37 0.42 1.59e-15 High light scatter reticulocyte count; LUSC cis rs2011503 0.941 rs76944848 chr19:19417512 C/T cg11244672 chr19:19639970 YJEFN3 -0.63 -7.39 -0.38 1.16e-12 Bipolar disorder; LUSC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg11494091 chr17:61959527 GH2 0.4 6.82 0.35 4.31e-11 Height; LUSC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg17077180 chr1:38461687 NA 0.55 9.63 0.47 1.6e-19 Coronary artery disease; LUSC cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12748703 chr10:97453984 TCTN3 -0.43 -6.25 -0.32 1.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg16797656 chr11:68205561 LRP5 0.36 5.97 0.31 6.15e-9 Total body bone mineral density; LUSC cis rs887829 0.569 rs4663963 chr2:234650193 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.59 -0.38 3.27e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs2439831 0.867 rs4583210 chr15:43660925 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 4.03e-19 Lung cancer in ever smokers; LUSC cis rs1018836 0.923 rs6986689 chr8:91626709 A/C cg16814680 chr8:91681699 NA -0.77 -12.99 -0.58 1.66e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg05861140 chr6:150128134 PCMT1 0.41 5.98 0.31 5.8e-9 Lung cancer; LUSC cis rs6495122 0.501 rs7167261 chr15:75343807 T/C cg14664628 chr15:75095509 CSK 0.42 6.07 0.31 3.56e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs861020 0.630 rs616544 chr1:210007368 T/C cg05527609 chr1:210001259 C1orf107 0.67 9.63 0.47 1.5700000000000001e-19 Orofacial clefts; LUSC cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.6 0.65 1.41e-41 Bladder cancer; LUSC cis rs8040855 0.644 rs2342120 chr15:85728820 G/T cg04831495 chr15:85060580 GOLGA6L5 0.4 6.54 0.34 2.33e-10 Bulimia nervosa; LUSC cis rs12824058 0.737 rs2398508 chr12:130816460 G/A cg23887609 chr12:130822674 PIWIL1 0.45 6.35 0.33 6.92e-10 Menopause (age at onset); LUSC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC trans rs11098499 0.779 rs7356491 chr4:120381974 C/T cg25214090 chr10:38739885 LOC399744 0.54 8.02 0.4 1.78e-14 Corneal astigmatism; LUSC cis rs2439831 0.850 rs28476182 chr15:44139643 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.91 0.35 2.39e-11 Lung cancer in ever smokers; LUSC cis rs7107174 1.000 rs10793300 chr11:78019582 T/A cg02023728 chr11:77925099 USP35 0.48 6.76 0.35 6.33e-11 Testicular germ cell tumor; LUSC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9905704 0.633 rs2018966 chr17:56477565 C/T cg12560992 chr17:57184187 TRIM37 -0.46 -5.65 -0.3 3.52e-8 Testicular germ cell tumor; LUSC trans rs11098499 0.955 rs7685268 chr4:120162188 G/A cg25214090 chr10:38739885 LOC399744 0.46 6.71 0.34 8.23e-11 Corneal astigmatism; LUSC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg12963246 chr6:28129442 ZNF389 0.48 6.55 0.34 2.12e-10 Depression; LUSC cis rs56146971 0.763 rs77450079 chr14:91863924 A/C cg10511902 chr14:91842949 CCDC88C 0.43 5.71 0.3 2.55e-8 Alzheimer disease and age of onset; LUSC cis rs17270561 0.562 rs74293932 chr6:26014811 C/A cg17042849 chr6:26104293 HIST1H4C -0.65 -7.42 -0.38 9.95e-13 Iron status biomarkers; LUSC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg16545954 chr1:2118288 C1orf86 -0.3 -5.95 -0.31 6.89e-9 Height; LUSC cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.1 0.32 2.95e-9 Rheumatoid arthritis; LUSC cis rs9952991 0.943 rs9952753 chr18:12780463 A/C cg23598886 chr18:12777645 NA 0.65 6.47 0.33 3.49e-10 Inflammatory skin disease; LUSC cis rs709400 0.628 rs11621510 chr14:103869620 T/C cg24130564 chr14:104152367 KLC1 -0.43 -6.1 -0.32 2.87e-9 Body mass index; LUSC cis rs4654899 0.802 rs12137203 chr1:21109088 T/A cg01072550 chr1:21505969 NA -0.48 -7.04 -0.36 1.12e-11 Superior frontal gyrus grey matter volume; LUSC cis rs2637266 1.000 rs2395386 chr10:78341623 C/T cg18941641 chr10:78392320 NA 0.36 6.69 0.34 9.6e-11 Pulmonary function; LUSC cis rs228769 0.792 rs454192 chr17:42171206 T/C cg19774624 chr17:42201019 HDAC5 0.7 8.95 0.44 2.45e-17 Bone mineral density (hip);Bone mineral density (spine); LUSC cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg15506890 chr2:3487001 NA -0.54 -8.6 -0.43 3.07e-16 Neurofibrillary tangles; LUSC cis rs36093844 0.559 rs10898403 chr11:85498451 A/G cg25872744 chr11:85566296 CCDC83 -0.43 -6.61 -0.34 1.53e-10 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg12560992 chr17:57184187 TRIM37 0.84 14.89 0.63 8.26e-39 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg15147215 chr3:52552868 STAB1 -0.32 -6.25 -0.32 1.24e-9 Bipolar disorder; LUSC cis rs950027 0.620 rs35861938 chr15:45637343 T/C cg26924012 chr15:45694286 SPATA5L1 0.78 12.36 0.56 3.65e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg21880101 chr17:80066754 CCDC57 -0.31 -5.8 -0.3 1.54e-8 Life satisfaction; LUSC trans rs2243480 1.000 rs313798 chr7:65493031 A/G cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.59e-15 Diabetic kidney disease; LUSC cis rs7189233 0.531 rs17800577 chr16:53476804 G/A cg09728985 chr16:53543985 NA -0.31 -5.69 -0.3 2.78e-8 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg15112475 chr7:1198522 ZFAND2A -0.33 -6.94 -0.36 1.99e-11 Longevity;Endometriosis; LUSC cis rs2456568 0.548 rs4753113 chr11:93660974 G/A cg26875233 chr11:93583750 C11orf90 -0.31 -6.06 -0.31 3.76e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg04455712 chr21:45112962 RRP1B 0.4 7.51 0.38 5.49e-13 Mean corpuscular volume; LUSC cis rs983392 0.591 rs3132886 chr11:60016387 T/A cg20284999 chr11:59952153 MS4A6A 0.39 6.46 0.33 3.75e-10 Alzheimer's disease (late onset); LUSC cis rs1018836 0.886 rs10112242 chr8:91642631 G/C cg16814680 chr8:91681699 NA -0.78 -12.9 -0.58 3.74e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.98 0.4 2.45e-14 Prudent dietary pattern; LUSC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs12908161 1.000 rs35808647 chr15:85377441 G/A cg12863693 chr15:85201151 NMB 0.38 7.77 0.39 1e-13 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10358630 chr2:130820810 NA 0.36 6.12 0.32 2.58e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs55871839 0.708 rs10098750 chr8:59813205 T/G cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs9467773 0.620 rs9461275 chr6:26590801 C/T cg05738196 chr6:26577821 NA 0.8 15.37 0.64 1.07e-40 Intelligence (multi-trait analysis); LUSC cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg08975724 chr8:8085496 FLJ10661 0.53 7.64 0.39 2.33e-13 Neuroticism; LUSC trans rs6445525 0.967 rs7648741 chr3:65996570 T/C cg12639933 chr12:57626296 SHMT2 0.34 6.18 0.32 1.87e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7532866 1.000 rs17163904 chr1:26741106 C/T cg17456097 chr1:26900765 RPS6KA1 0.41 6.41 0.33 4.91e-10 Height; LUSC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg12751644 chr20:60527061 NA -0.32 -5.71 -0.3 2.44e-8 Body mass index; LUSC cis rs9788682 0.747 rs12101809 chr15:78779801 C/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.98 -0.31 5.88e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs3824867 0.920 rs7105907 chr11:47450318 A/T cg20307385 chr11:47447363 PSMC3 -0.64 -9.52 -0.46 3.67e-19 Mean corpuscular hemoglobin; LUSC cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg17366294 chr4:99064904 C4orf37 0.53 7.43 0.38 8.9e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs981844 0.767 rs6857738 chr4:154689140 A/C cg14289246 chr4:154710475 SFRP2 -0.52 -7.33 -0.37 1.76e-12 Response to statins (LDL cholesterol change); LUSC cis rs3820928 0.967 rs4675113 chr2:227766339 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.73 -0.39 1.3e-13 Pulmonary function; LUSC cis rs9807989 0.811 rs11688559 chr2:102969913 C/T cg03938978 chr2:103052716 IL18RAP 0.31 5.79 0.3 1.58e-8 Asthma; LUSC cis rs2204008 0.837 rs10876019 chr12:37985477 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.93 0.66 6.63e-43 Bladder cancer; LUSC cis rs62344088 1.000 rs10065373 chr5:106819 C/T cg22857025 chr5:266934 NA -0.95 -6.99 -0.36 1.53e-11 Asthma (childhood onset); LUSC cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg06462663 chr19:18546047 ISYNA1 0.49 8.44 0.42 9.79e-16 Breast cancer; LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14957430 chr2:64995219 NA 0.46 6.6 0.34 1.65e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10789491 1.000 rs10789491 chr1:47179310 A/G cg15501359 chr1:47185051 KIAA0494 0.81 11.42 0.53 1.05e-25 Response to hepatitis C treatment; LUSC cis rs12493885 0.818 rs6800048 chr3:153766181 T/C cg17054900 chr3:154042577 DHX36 -0.57 -6.07 -0.32 3.42e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.18 0.52 7.28e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.05 -0.36 1.06e-11 Blood metabolite levels; LUSC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg09165964 chr15:75287851 SCAMP5 -1.01 -15.29 -0.64 2.16e-40 Blood trace element (Zn levels); LUSC cis rs2078087 0.568 rs498993 chr1:183240470 C/T cg13843938 chr1:183241246 NMNAT2 -0.42 -6.82 -0.35 4.2e-11 Obesity-related traits; LUSC cis rs9790314 0.905 rs4518145 chr3:160950030 T/C cg04691961 chr3:161091175 C3orf57 -0.34 -5.9 -0.31 8.92e-9 Morning vs. evening chronotype; LUSC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg05805236 chr11:65401703 PCNXL3 -0.37 -5.73 -0.3 2.29e-8 Breast cancer; LUSC cis rs17401966 0.838 rs35257796 chr1:10267390 T/A cg19773385 chr1:10388646 KIF1B -0.51 -8.65 -0.43 2.17e-16 Hepatocellular carcinoma; LUSC cis rs9486719 1.000 rs2971608 chr6:97039757 T/C cg06623918 chr6:96969491 KIAA0776 -0.85 -12.43 -0.56 2.07e-29 Migraine;Coronary artery disease; LUSC cis rs9814567 1.000 rs9863786 chr3:134247203 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10035650 0.510 rs6898585 chr5:93896128 A/G cg21051031 chr5:93905482 C5orf36;MIR1974 0.37 6.02 0.31 4.49e-9 Cancer; LUSC cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg05868516 chr6:26286170 HIST1H4H 0.37 6.05 0.31 3.94e-9 Educational attainment; LUSC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg08219700 chr8:58056026 NA 0.5 6.27 0.32 1.11e-9 Developmental language disorder (linguistic errors); LUSC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg24154853 chr7:158122151 PTPRN2 0.45 8.8 0.43 7.55e-17 Calcium levels; LUSC cis rs77106637 0.860 rs11603334 chr11:72432985 G/A cg04827223 chr11:72435913 ARAP1 -0.77 -9.04 -0.44 1.31e-17 Type 2 diabetes; LUSC cis rs9790314 1.000 rs4273380 chr3:160950314 A/G cg03342759 chr3:160939853 NMD3 -0.5 -8.49 -0.42 6.88e-16 Morning vs. evening chronotype; LUSC cis rs9660992 0.626 rs9326600 chr1:205245268 G/A cg21643547 chr1:205240462 TMCC2 -0.45 -8.87 -0.44 4.45e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg01368799 chr11:117014884 PAFAH1B2 0.49 6.48 0.33 3.38e-10 Blood protein levels; LUSC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs6693567 0.565 rs834243 chr1:150339290 C/A cg15654264 chr1:150340011 RPRD2 0.44 7.04 0.36 1.11e-11 Migraine; LUSC cis rs9399135 0.967 rs4896120 chr6:135293512 C/G cg24558204 chr6:135376177 HBS1L 0.57 8.66 0.43 2.1e-16 Red blood cell count; LUSC cis rs983392 0.679 rs7121656 chr11:60024008 C/T cg20284999 chr11:59952153 MS4A6A 0.4 6.82 0.35 4.22e-11 Alzheimer's disease (late onset); LUSC cis rs11031096 0.702 rs34356743 chr11:4153891 T/C cg18678763 chr11:4115507 RRM1 0.38 5.77 0.3 1.83e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6546550 0.901 rs6721891 chr2:70146121 A/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.26 -0.37 2.67e-12 Prevalent atrial fibrillation; LUSC cis rs9905704 0.813 rs304269 chr17:56802059 A/G cg12560992 chr17:57184187 TRIM37 -0.58 -8.46 -0.42 8.33e-16 Testicular germ cell tumor; LUSC cis rs7771547 0.573 rs9470278 chr6:36399239 G/A cg07856975 chr6:36356162 ETV7 -0.35 -6.3 -0.33 9.53e-10 Platelet distribution width; LUSC cis rs2760061 0.603 rs697762 chr1:228192410 G/A cg20976159 chr1:228193529 WNT3A 0.29 5.86 0.31 1.11e-8 Diastolic blood pressure; LUSC cis rs9296092 0.517 rs7775914 chr6:33518110 T/C cg13560919 chr6:33536144 NA -0.82 -15.79 -0.65 2.45e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2839186 0.967 rs17176131 chr21:47705237 T/C cg13126279 chr21:47581558 C21orf56 -0.42 -6.15 -0.32 2.19e-9 Testicular germ cell tumor; LUSC cis rs10791097 0.720 rs4936121 chr11:130733878 A/G cg12179176 chr11:130786555 SNX19 0.82 13.73 0.6 2.54e-34 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6754311 0.731 rs745500 chr2:136583192 G/A cg07169764 chr2:136633963 MCM6 -0.59 -7.64 -0.39 2.34e-13 Mosquito bite size; LUSC cis rs41271473 0.500 rs10916366 chr1:228894575 T/C cg10167378 chr1:228756711 NA 0.47 6.49 0.33 3.04e-10 Chronic lymphocytic leukemia; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.71 10.89 0.51 7.63e-24 Lymphocyte counts; LUSC cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg01256987 chr12:42539512 GXYLT1 -0.45 -8.53 -0.42 5.06e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16695835 chr1:90460886 LOC492303;ZNF326 0.76 6.02 0.31 4.54e-9 Cognitive performance; LUSC trans rs61931739 1.000 rs12424741 chr12:34022771 C/T cg13010199 chr12:38710504 ALG10B -0.39 -5.95 -0.31 6.67e-9 Morning vs. evening chronotype; LUSC cis rs9811920 0.555 rs9850382 chr3:99915939 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.33 6.26 0.32 1.18e-9 Axial length; LUSC cis rs8068544 0.818 rs79892925 chr17:40171819 A/G cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -1.24 -11.38 -0.53 1.46e-25 Reticulocyte fraction of red cells;Reticulocyte count; LUSC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg11317459 chr13:21872234 NA 1.26 19.59 0.73 1.93e-57 White matter hyperintensity burden; LUSC cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -8.64 -0.43 2.32e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg14895029 chr7:2775587 GNA12 -0.42 -6.21 -0.32 1.54e-9 Height; LUSC cis rs936229 0.654 rs762551 chr15:75041917 C/A cg14664628 chr15:75095509 CSK -0.86 -13.65 -0.6 5.05e-34 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7605827 0.930 rs11676198 chr2:15603097 G/A cg19274914 chr2:15703543 NA 0.46 8.74 0.43 1.16e-16 Educational attainment (years of education); LUSC cis rs7582720 1.000 rs114079739 chr2:203825106 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs11785693 0.862 rs7007542 chr8:4996718 G/A cg26367366 chr8:4980734 NA 0.73 8.61 0.43 2.9e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.72 -11.69 -0.54 1.1e-26 Colorectal cancer; LUSC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg11344533 chr11:111475393 SIK2 -0.49 -6.85 -0.35 3.5e-11 Primary sclerosing cholangitis; LUSC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg06008330 chr7:65541103 ASL -0.4 -6.23 -0.32 1.43e-9 Aortic root size; LUSC cis rs1451375 0.617 rs2329366 chr7:50544966 G/A cg18232548 chr7:50535776 DDC -0.53 -7.42 -0.38 9.56e-13 Malaria; LUSC cis rs62064224 0.791 rs17806082 chr17:30705346 G/C cg18200150 chr17:30822561 MYO1D 0.52 10.48 0.5 2.14e-22 Schizophrenia; LUSC cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg13256891 chr4:100009986 ADH5 0.46 6.32 0.33 8.54e-10 Alcohol dependence; LUSC cis rs708547 0.647 rs1718831 chr4:57886946 T/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.64 0.39 2.25e-13 Response to bleomycin (chromatid breaks); LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg16405210 chr4:1374714 KIAA1530 -0.83 -14.48 -0.62 3.14e-37 Longevity; LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.68 -0.43 1.72e-16 Bipolar disorder; LUSC cis rs611744 0.647 rs13280487 chr8:109270263 G/C cg18478394 chr8:109455254 TTC35 0.42 6.54 0.34 2.35e-10 Dupuytren's disease; LUSC cis rs11098499 0.722 rs10006192 chr4:120263022 T/C cg24375607 chr4:120327624 NA 0.7 11.14 0.52 1.03e-24 Corneal astigmatism; LUSC cis rs11190604 0.767 rs12360395 chr10:102194074 A/T cg07080220 chr10:102295463 HIF1AN 0.61 8.14 0.41 8.11e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg00106254 chr7:1943704 MAD1L1 -0.4 -5.97 -0.31 6.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg03146154 chr1:46216737 IPP -0.57 -8.23 -0.41 4.16e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1908814 0.516 rs7825529 chr8:11794444 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.16 0.32 2.13e-9 Neuroticism; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg24060136 chr17:18162181 FLII 0.39 6.08 0.32 3.2e-9 Schizophrenia; LUSC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg08564027 chr20:61660810 NA 0.91 17.47 0.69 5.29e-49 Prostate cancer (SNP x SNP interaction); LUSC trans rs1908814 0.516 rs7812563 chr8:11794488 T/G cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.67e-16 Neuroticism; LUSC cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06544989 chr22:39130855 UNC84B 0.34 6.19 0.32 1.81e-9 Menopause (age at onset); LUSC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.1e-30 Aortic root size; LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T cg11505180 chr12:75724112 CAPS2 -0.44 -6.53 -0.34 2.49e-10 Leprosy; LUSC cis rs7474896 0.507 rs2474555 chr10:38465220 G/C cg25427524 chr10:38739819 LOC399744 -0.51 -6.29 -0.33 9.74e-10 Obesity (extreme); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03311064 chr5:139781280 ANKHD1;ANKHD1-EIF4EBP3 -0.44 -6.6 -0.34 1.62e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg10523860 chr14:103875565 MARK3 -0.38 -6.23 -0.32 1.44e-9 Body mass index; LUSC cis rs2050392 0.517 rs687036 chr10:30761249 G/A cg25182066 chr10:30743637 MAP3K8 -0.44 -6.68 -0.34 9.75e-11 Inflammatory bowel disease; LUSC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg02569458 chr12:86230093 RASSF9 0.52 8.64 0.43 2.3e-16 Major depressive disorder; LUSC cis rs1371867 0.764 rs1020171 chr8:101288610 T/C cg00191853 chr8:101177733 SPAG1 -0.39 -6.35 -0.33 7.09e-10 Atrioventricular conduction; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19424343 chr3:16306684 OXNAD1;DPH3 -0.45 -6.73 -0.35 7.28e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs5769707 0.521 rs739244 chr22:50060158 A/G cg07959070 chr22:50026188 C22orf34 -0.31 -5.65 -0.3 3.45e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg17971929 chr21:40555470 PSMG1 -0.69 -11.53 -0.53 4.06e-26 Cognitive function; LUSC cis rs782590 0.902 rs7582278 chr2:55742924 C/G cg18811423 chr2:55921094 PNPT1 0.82 14.37 0.62 8.34e-37 Metabolic syndrome; LUSC cis rs11167764 0.895 rs9324865 chr5:141488792 T/C cg08523384 chr5:141488047 NDFIP1 -0.49 -6.93 -0.35 2.21e-11 Crohn's disease; LUSC cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.75 0.43 1.1e-16 Axial length; LUSC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg26335602 chr6:28129616 ZNF389 0.46 6.06 0.31 3.64e-9 Depression; LUSC cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg12615879 chr12:58013172 SLC26A10 -0.31 -6.55 -0.34 2.18e-10 Multiple sclerosis; LUSC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.05 -0.36 1.02e-11 Colorectal cancer; LUSC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.38 0.33 5.86e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3540 0.597 rs3539 chr15:91045419 G/T cg22089800 chr15:90895588 ZNF774 -0.64 -9.65 -0.47 1.3e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6121246 0.529 rs6120862 chr20:30199459 T/C cg13852791 chr20:30311386 BCL2L1 0.76 8.67 0.43 1.92e-16 Mean corpuscular hemoglobin; LUSC cis rs4629710 0.545 rs2077490 chr6:131554184 C/T cg12606694 chr6:131520996 AKAP7 0.58 8.85 0.44 5.12e-17 Multiple myeloma (IgH translocation); LUSC cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg21643547 chr1:205240462 TMCC2 -0.53 -10.15 -0.49 2.88e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs11700980 0.551 rs12481819 chr21:30113901 G/T cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs921968 0.608 rs11678428 chr2:219352598 C/T cg02176678 chr2:219576539 TTLL4 0.62 11.11 0.52 1.28e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg12365402 chr11:9010492 NRIP3 -0.51 -9.7 -0.47 9.39e-20 Hemoglobin concentration; LUSC cis rs6750047 0.566 rs1157185 chr2:38285735 C/T cg07380506 chr2:38303506 CYP1B1 0.44 6.19 0.32 1.73e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg06637938 chr14:75390232 RPS6KL1 0.54 8.56 0.42 4.04e-16 Height; LUSC cis rs2898290 0.592 rs2736342 chr8:11347289 A/C cg27411982 chr8:10470053 RP1L1 -0.37 -5.77 -0.3 1.79e-8 Systolic blood pressure; LUSC cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg01765077 chr12:122356316 WDR66 -0.51 -7.33 -0.37 1.78e-12 Mean corpuscular volume; LUSC cis rs13315871 1.000 rs9864325 chr3:58336846 A/C cg20936604 chr3:58311152 NA -0.66 -6.72 -0.35 7.73e-11 Cholesterol, total; LUSC cis rs934734 1.000 rs934734 chr2:65595586 A/G cg08085232 chr2:65598271 SPRED2 0.37 5.84 0.3 1.26e-8 Rheumatoid arthritis; LUSC cis rs4631830 0.720 rs2125771 chr10:51506957 C/T cg16070123 chr10:51489643 NA -0.57 -9.46 -0.46 5.83e-19 Prostate-specific antigen levels; LUSC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2e-10 Reticulocyte fraction of red cells; LUSC cis rs9457247 0.602 rs2239827 chr6:167490945 G/A cg06454157 chr6:167490870 NA -0.29 -6.58 -0.34 1.77e-10 Crohn's disease; LUSC cis rs2425143 1.000 rs7264414 chr20:34446826 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -6.09 -0.32 3.08e-9 Blood protein levels; LUSC cis rs9399401 0.601 rs262130 chr6:142853486 C/T cg03128060 chr6:142623767 GPR126 0.51 8.51 0.42 6.12e-16 Chronic obstructive pulmonary disease; LUSC cis rs75920871 0.588 rs10892054 chr11:116868221 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.76 -0.35 6.07e-11 Subjective well-being; LUSC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg07741184 chr6:167504864 NA 0.43 7.63 0.39 2.43e-13 Crohn's disease; LUSC cis rs4319547 0.626 rs11057882 chr12:122875046 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.42 -0.42 1.12e-15 Body mass index; LUSC cis rs7011049 1.000 rs72640868 chr8:53843812 C/A cg26025543 chr8:53854495 NA 0.53 6.35 0.33 7.13e-10 Systolic blood pressure; LUSC cis rs6546550 0.867 rs4852349 chr2:70076954 A/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.36 -0.37 1.4e-12 Prevalent atrial fibrillation; LUSC cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7189233 0.531 rs11859538 chr16:53497045 A/G cg09728985 chr16:53543985 NA -0.33 -6.13 -0.32 2.46e-9 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg27094323 chr7:1216898 NA -0.35 -6.14 -0.32 2.32e-9 Longevity;Endometriosis; LUSC cis rs4443100 0.916 rs6003495 chr22:23399743 A/G cg21100191 chr22:23484243 RTDR1 0.46 5.68 0.3 2.97e-8 Serum parathyroid hormone levels; LUSC cis rs4499344 0.633 rs259262 chr19:33153951 G/A cg22980127 chr19:33182716 NUDT19 -0.44 -6.45 -0.33 3.88e-10 Mean platelet volume; LUSC cis rs2730245 0.527 rs2527194 chr7:158732959 G/A cg24397884 chr7:158709396 WDR60 -0.79 -9.07 -0.44 1.05e-17 Height; LUSC cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg21466736 chr12:48725269 NA -0.33 -5.75 -0.3 2.06e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg27129171 chr3:47204927 SETD2 0.69 11.49 0.53 5.55e-26 Colorectal cancer; LUSC cis rs6964587 0.933 rs6465350 chr7:91768615 G/A cg01689657 chr7:91764605 CYP51A1 0.33 5.95 0.31 6.81e-9 Breast cancer; LUSC trans rs9329221 0.638 rs7460436 chr8:10254322 C/T cg15556689 chr8:8085844 FLJ10661 0.63 8.76 0.43 9.86e-17 Neuroticism; LUSC cis rs6752107 0.967 rs3816234 chr2:234185999 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.69 11.57 0.53 3e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9534288 0.619 rs2146881 chr13:46679598 T/C cg15192986 chr13:46630673 CPB2 -0.76 -11.19 -0.52 6.93e-25 Blood protein levels; LUSC cis rs2074585 0.647 rs2601188 chr15:90929563 A/G cg22089800 chr15:90895588 ZNF774 -0.45 -7.05 -0.36 1.02e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs34638657 0.732 rs4889477 chr16:82201302 C/T cg09439754 chr16:82129088 HSD17B2 -0.39 -6.33 -0.33 7.89e-10 Lung adenocarcinoma; LUSC cis rs1559088 0.948 rs7247748 chr19:33594023 T/C cg27124370 chr19:33622961 WDR88 0.56 7.38 0.37 1.27e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg16339924 chr4:17578868 LAP3 0.52 8.0 0.4 2.05e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg00343986 chr7:65444356 GUSB -0.42 -6.07 -0.32 3.41e-9 Aortic root size; LUSC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg06640241 chr16:89574553 SPG7 0.88 15.87 0.66 1.12e-42 Multiple myeloma (IgH translocation); LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg00024416 chr22:24240387 NA 0.34 5.86 0.31 1.14e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -13.96 -0.61 3.17e-35 Hemoglobin concentration; LUSC trans rs7819412 0.521 rs2409720 chr8:11037903 A/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.14 -0.36 6.05e-12 Triglycerides; LUSC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs2361718 0.568 rs1042397 chr17:78092063 G/A cg09238746 chr17:78121135 EIF4A3 -0.69 -10.21 -0.49 1.75e-21 Yeast infection; LUSC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.76 -0.54 6.18e-27 Extrinsic epigenetic age acceleration; LUSC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.96e-13 Obesity-related traits; LUSC cis rs62158211 0.955 rs1823125 chr2:114090412 C/T cg17784749 chr2:114082611 LOC440839 -0.47 -5.82 -0.3 1.4e-8 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; LUSC cis rs7511006 0.893 rs5771104 chr22:50651839 C/T cg16473166 chr22:50639996 SELO 0.65 9.27 0.45 2.45e-18 Obesity-related traits; LUSC cis rs9467603 0.566 rs10214468 chr6:25789390 T/A cg08501292 chr6:25962987 TRIM38 0.6 6.13 0.32 2.51e-9 Intelligence (multi-trait analysis); LUSC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.11 -0.41 9.67e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2073300 1.000 rs78000067 chr20:23439507 A/G cg12062639 chr20:23401060 NAPB 0.92 6.76 0.35 6.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg10645314 chr2:3704589 ALLC -0.48 -7.25 -0.37 2.92e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.42e-17 Prudent dietary pattern; LUSC cis rs6977660 0.714 rs17141882 chr7:19790217 C/T cg05791153 chr7:19748676 TWISTNB 0.79 8.56 0.42 4.24e-16 Thyroid stimulating hormone; LUSC cis rs193541 0.565 rs4836224 chr5:122092875 A/C cg19077854 chr5:122220652 SNX24 0.28 6.25 0.32 1.29e-9 Glucose homeostasis traits; LUSC cis rs7809950 0.871 rs11771278 chr7:107285925 C/T cg23024343 chr7:107201750 COG5 0.4 6.03 0.31 4.38e-9 Coronary artery disease; LUSC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.77e-16 Aortic root size; LUSC cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.95 0.31 6.61e-9 Rheumatoid arthritis; LUSC trans rs6502050 0.835 rs55679819 chr17:80105450 C/T cg07393940 chr7:158741817 NA 0.36 6.48 0.33 3.33e-10 Life satisfaction; LUSC cis rs79149102 0.579 rs7173218 chr15:75315328 A/G cg09165964 chr15:75287851 SCAMP5 -0.89 -8.41 -0.42 1.22e-15 Lung cancer; LUSC cis rs947211 0.898 rs10900524 chr1:205748309 G/A cg14893161 chr1:205819251 PM20D1 0.45 5.99 0.31 5.44e-9 Parkinson's disease; LUSC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg07636037 chr3:49044803 WDR6 -0.44 -6.34 -0.33 7.64e-10 Resting heart rate; LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg13560548 chr3:10150139 C3orf24 0.48 6.6 0.34 1.6e-10 Alzheimer's disease; LUSC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs1775715 0.513 rs2808089 chr10:32145112 A/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.82 0.39 6.89e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.64 -0.34 1.3100000000000001e-10 Lung cancer; LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg04944784 chr2:26401820 FAM59B -0.69 -9.7 -0.47 9.47e-20 Gut microbiome composition (summer); LUSC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs11971779 0.618 rs6943788 chr7:139087697 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1355223 0.583 rs1549789 chr11:34867947 G/A cg24088639 chr11:34937564 PDHX;APIP -0.47 -6.98 -0.36 1.56e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg00825309 chr19:58991885 ZNF446 -0.5 -7.19 -0.37 4.36e-12 Uric acid clearance; LUSC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 6.56 0.34 2.11e-10 Personality dimensions; LUSC cis rs7786808 0.504 rs10949725 chr7:158196003 C/T cg09998033 chr7:158218633 PTPRN2 0.44 7.05 0.36 1.04e-11 Obesity-related traits; LUSC cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs10743315 0.557 rs78983750 chr12:19284967 C/T cg02471346 chr12:19282374 PLEKHA5 0.94 6.81 0.35 4.67e-11 Gut microbiota (bacterial taxa); LUSC cis rs6942756 0.747 rs598412 chr7:129127736 C/T cg02491457 chr7:128862824 NA 0.4 5.65 0.3 3.42e-8 White matter hyperintensity burden; LUSC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg06221963 chr1:154839813 KCNN3 -0.59 -12.98 -0.58 1.77e-31 Prostate cancer; LUSC trans rs61931739 0.517 rs1843737 chr12:34015305 A/G cg13010199 chr12:38710504 ALG10B 0.49 7.66 0.39 2.08e-13 Morning vs. evening chronotype; LUSC cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 2e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.78 -0.3 1.7e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs1506636 0.924 rs4370458 chr7:123260968 G/A cg03229431 chr7:123269106 ASB15 -0.67 -11.13 -0.52 1.11e-24 Plateletcrit;Platelet count; LUSC trans rs12210905 0.925 rs4541737 chr6:27002821 C/T cg11837749 chr1:55047332 ACOT11 0.59 6.3 0.33 9.16e-10 Hip circumference adjusted for BMI; LUSC cis rs897984 0.683 rs12926237 chr16:30837596 C/T cg00531865 chr16:30841666 NA 0.34 5.94 0.31 6.99e-9 Dementia with Lewy bodies; LUSC cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.75 -0.35 6.53e-11 Monocyte percentage of white cells; LUSC cis rs727505 1.000 rs1541416 chr7:124450345 T/C cg23710748 chr7:124431027 NA -0.41 -7.32 -0.37 1.88e-12 Lewy body disease; LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.87 0.63 9.77e-39 Platelet count; LUSC cis rs1005224 0.895 rs6574252 chr14:76141834 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.63 -8.71 -0.43 1.42e-16 Large artery stroke; LUSC cis rs4631830 0.869 rs7896437 chr10:51529593 A/C cg10326726 chr10:51549505 MSMB -0.36 -6.07 -0.32 3.54e-9 Prostate-specific antigen levels; LUSC cis rs599083 0.590 rs10791984 chr11:68407835 T/G cg20283391 chr11:68216788 NA 0.53 7.79 0.39 8.3e-14 Bone mineral density (spine); LUSC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.0 -0.31 5.02e-9 Bipolar disorder; LUSC trans rs61931739 0.559 rs4385974 chr12:34313128 G/C cg26384229 chr12:38710491 ALG10B 0.55 8.73 0.43 1.24e-16 Morning vs. evening chronotype; LUSC cis rs694739 0.657 rs11231770 chr11:64140625 G/A cg23796481 chr11:64053134 BAD;GPR137 0.53 8.18 0.41 6.18e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs4969178 0.600 rs2376583 chr17:76402105 A/T cg20026190 chr17:76395443 PGS1 0.34 5.79 0.3 1.66e-8 HDL cholesterol levels; LUSC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06544989 chr22:39130855 UNC84B 0.32 5.72 0.3 2.31e-8 Menopause (age at onset); LUSC cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.71 0.34 8.58e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10904908 0.829 rs359282 chr10:17325281 G/A cg01003015 chr10:17271136 VIM 0.41 6.05 0.31 3.86e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg18252515 chr7:66147081 NA -1.22 -14.19 -0.61 4.12e-36 Diabetic kidney disease; LUSC cis rs17685 0.712 rs1639620 chr7:75704090 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.7 -0.39 1.58e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9463078 0.764 rs1854547 chr6:44912366 G/A cg25276700 chr6:44698697 NA -0.29 -5.9 -0.31 8.73e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7202877 0.706 rs247436 chr16:75445971 T/G cg04384234 chr16:75411784 CFDP1 0.65 8.88 0.44 4.14e-17 Type 2 diabetes;Type 1 diabetes; LUSC trans rs16930685 1.000 rs292784 chr11:37869212 C/T cg14690467 chr7:148917905 ZNF282 -0.41 -5.97 -0.31 6.1e-9 Cutaneous nevi; LUSC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg14092988 chr3:52407081 DNAH1 0.33 6.33 0.33 7.77e-10 Bipolar disorder; LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg21138405 chr5:131827807 IRF1 -0.54 -10.37 -0.49 4.99e-22 Asthma (sex interaction); LUSC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg00484396 chr16:3507460 NAT15 -0.74 -9.39 -0.46 9.62e-19 Tuberculosis; LUSC cis rs3942852 0.868 rs6485808 chr11:48109151 A/G cg20307385 chr11:47447363 PSMC3 0.52 6.22 0.32 1.52e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.48 -6.44 -0.33 4.09e-10 Tonsillectomy; LUSC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs7408868 0.831 rs7249115 chr19:15280765 A/G cg14696996 chr19:15285081 NOTCH3 0.82 8.3 0.41 2.59e-15 Pulse pressure; LUSC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg22655196 chr4:3374909 RGS12 0.32 6.42 0.33 4.61e-10 Serum sulfate level; LUSC cis rs2463822 0.583 rs11600383 chr11:62060451 A/G cg06239285 chr11:62104954 ASRGL1 0.55 5.83 0.3 1.3e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13315871 0.929 rs7635697 chr3:58313706 G/A cg20936604 chr3:58311152 NA -0.77 -7.11 -0.36 7.27e-12 Cholesterol, total; LUSC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.23 0.45 3.14e-18 Prostate cancer (SNP x SNP interaction); LUSC trans rs11764590 0.950 rs55683212 chr7:2078855 G/C cg25206134 chr2:45395956 NA 0.61 7.08 0.36 8.57e-12 Neuroticism; LUSC trans rs11098499 0.909 rs71614422 chr4:120359340 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.2 0.41 5.25e-15 Corneal astigmatism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05910615 chr19:36248877 HSPB6;C19orf55 -0.52 -6.91 -0.35 2.51e-11 Bipolar disorder and schizophrenia; LUSC cis rs10751667 0.580 rs11246363 chr11:971667 T/C ch.11.42038R chr11:967971 AP2A2 0.42 6.23 0.32 1.37e-9 Alzheimer's disease (late onset); LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg10729496 chr3:10149963 C3orf24 0.51 6.89 0.35 2.74e-11 Alzheimer's disease; LUSC cis rs2692947 0.644 rs1168976 chr2:96813480 G/A cg22654517 chr2:96458247 NA 0.32 5.88 0.31 9.97e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg25036284 chr2:26402008 FAM59B 0.75 9.21 0.45 3.77e-18 Gut microbiome composition (summer); LUSC cis rs7508679 1.000 rs4804411 chr19:7222377 G/C cg00428638 chr19:7224713 INSR 0.35 7.6 0.38 2.98e-13 Hypothyroidism; LUSC trans rs2739330 0.753 rs4822452 chr22:24254363 C/T cg06437703 chr8:37914619 EIF4EBP1 -0.54 -8.42 -0.42 1.15e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs4927850 1.000 rs7630875 chr3:195753766 A/G cg16724585 chr3:197361211 NA -0.62 -8.71 -0.43 1.45e-16 Pancreatic cancer; LUSC trans rs12310956 0.510 rs10844694 chr12:33865682 A/C cg13010199 chr12:38710504 ALG10B 0.46 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs713477 1.000 rs713477 chr14:55904426 C/A cg13175173 chr14:55914753 NA -0.31 -6.39 -0.33 5.64e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.15 -0.49 2.8e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg24829409 chr8:58192753 C8orf71 -0.47 -5.91 -0.31 8.56e-9 Developmental language disorder (linguistic errors); LUSC cis rs2280018 0.526 rs2966129 chr16:15152927 A/C cg27102117 chr16:15229624 NA -0.48 -7.63 -0.39 2.42e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg19592336 chr6:28129416 ZNF389 0.45 6.0 0.31 5.12e-9 Depression; LUSC cis rs9788721 0.902 rs114205691 chr15:78901113 C/T cg18825076 chr15:78729989 IREB2 -0.51 -7.91 -0.4 3.77e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6121246 0.529 rs56153385 chr20:30187609 C/T cg13852791 chr20:30311386 BCL2L1 0.72 8.29 0.41 2.73e-15 Mean corpuscular hemoglobin; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25007487 chr6:74079672 OOEP 0.43 6.05 0.31 3.93e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg26872149 chr2:157191396 NA 0.4 6.1 0.32 2.9e-9 Major depressive disorder; LUSC cis rs2274273 0.638 rs67416413 chr14:55702263 A/G cg04306507 chr14:55594613 LGALS3 0.48 9.5 0.46 4.1e-19 Protein biomarker; LUSC cis rs939658 0.967 rs11629665 chr15:79457133 C/T cg17916960 chr15:79447300 NA 0.46 9.41 0.46 8.45e-19 Refractive error; LUSC cis rs7428 0.545 rs17026212 chr2:85551696 T/G cg24342717 chr2:85555507 TGOLN2 -0.74 -11.93 -0.55 1.44e-27 Ear protrusion; LUSC cis rs12421382 0.659 rs2165137 chr11:109381995 G/T cg16359550 chr11:109292809 C11orf87 0.37 6.37 0.33 6.08e-10 Schizophrenia; LUSC cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg03517284 chr6:25882590 NA -0.52 -9.67 -0.47 1.16e-19 Blood metabolite levels; LUSC cis rs1348850 0.526 rs59972556 chr2:178399561 A/G cg22681709 chr2:178499509 PDE11A -0.46 -6.78 -0.35 5.57e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg02117656 chr17:79614917 TSPAN10 0.31 5.7 0.3 2.63e-8 Eye color traits; LUSC trans rs979233 0.522 rs593256 chr5:42085687 T/C cg07010552 chr17:7358735 CHRNB1 -0.42 -6.11 -0.32 2.7e-9 Systemic lupus erythematosus; LUSC cis rs7760535 0.931 rs466923 chr6:111662977 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.85 -0.35 3.51e-11 Metabolic traits; LUSC cis rs4478858 0.735 rs68008576 chr1:31805905 T/C cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs11711311 0.911 rs34337798 chr3:113396704 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -6.0 -0.31 5.01e-9 IgG glycosylation; LUSC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg01416388 chr22:39784598 NA 0.43 6.56 0.34 2.06e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9905704 0.647 rs12940492 chr17:56954655 C/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.33 -0.37 1.75e-12 Testicular germ cell tumor; LUSC trans rs10911902 0.913 rs80040530 chr1:186572184 T/C cg03946955 chr1:156096301 LMNA -0.43 -6.04 -0.31 4.22e-9 Schizophrenia; LUSC cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg18252515 chr7:66147081 NA -1.24 -14.64 -0.63 7.55e-38 Diabetic kidney disease; LUSC cis rs12368653 0.641 rs12826708 chr12:58058373 G/A cg15848620 chr12:58087721 OS9 -0.41 -5.92 -0.31 8.09e-9 Multiple sclerosis; LUSC trans rs1325195 0.920 rs9728480 chr1:179089491 A/C cg11624085 chr17:8464688 MYH10 -0.44 -7.38 -0.37 1.25e-12 IgE grass sensitization; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.91 0.31 8.67e-9 Menopause (age at onset); LUSC cis rs12928939 0.774 rs7192860 chr16:71643622 G/A cg08717414 chr16:71523259 ZNF19 -0.44 -6.13 -0.32 2.53e-9 Post bronchodilator FEV1; LUSC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg00343986 chr7:65444356 GUSB -0.47 -7.01 -0.36 1.3e-11 Calcium levels; LUSC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg17633681 chr16:88106987 BANP 0.53 10.12 0.48 3.63e-21 Menopause (age at onset); LUSC cis rs1348850 0.608 rs10176632 chr2:178225934 G/T cg22681709 chr2:178499509 PDE11A -0.35 -6.26 -0.32 1.2e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11958404 0.932 rs72816595 chr5:157435957 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg11050988 chr7:1952600 MAD1L1 -0.32 -6.11 -0.32 2.84e-9 Bipolar disorder and schizophrenia; LUSC cis rs6740322 1.000 rs6756736 chr2:43558743 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.46 -6.4 -0.33 5.12e-10 Coronary artery disease; LUSC trans rs9929218 0.954 rs7198799 chr16:68818390 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.55 -0.53 3.33e-26 Colorectal cancer; LUSC cis rs17125944 0.505 rs77949716 chr14:53204234 G/A cg13660082 chr14:53194042 PSMC6 -0.8 -6.96 -0.36 1.78e-11 Alzheimer's disease (late onset); LUSC cis rs2760061 0.626 rs596208 chr1:228117982 G/C cg02753203 chr1:228287806 NA -0.66 -11.34 -0.53 1.95e-25 Diastolic blood pressure; LUSC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.78 -0.39 9.28e-14 Personality dimensions; LUSC cis rs7937890 0.904 rs67623158 chr11:14295196 T/C cg02886208 chr11:14281011 SPON1 0.33 5.94 0.31 7.07e-9 Mitochondrial DNA levels; LUSC cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg05294307 chr14:35346193 BAZ1A -0.58 -6.38 -0.33 5.78e-10 Psoriasis; LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs9811920 0.683 rs793502 chr3:99588417 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.34 6.56 0.34 2.11e-10 Axial length; LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg11494091 chr17:61959527 GH2 0.63 13.63 0.6 6.26e-34 Prudent dietary pattern; LUSC cis rs7215564 0.908 rs74000898 chr17:78653532 A/C cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs2898681 0.614 rs4864680 chr4:53708421 T/G cg00338735 chr4:53728038 RASL11B 0.43 5.86 0.31 1.11e-8 Optic nerve measurement (cup area); LUSC cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.78 -0.35 5.63e-11 Alzheimer's disease (late onset); LUSC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg02574844 chr11:5959923 NA -0.45 -6.36 -0.33 6.66e-10 DNA methylation (variation); LUSC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg05043794 chr9:111880884 C9orf5 0.35 7.5 0.38 5.66e-13 Menarche (age at onset); LUSC cis rs796364 0.951 rs7586284 chr2:201068002 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.71 0.3 2.56e-8 Schizophrenia; LUSC cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg01579765 chr21:45077557 HSF2BP -0.47 -9.72 -0.47 7.86e-20 Mean corpuscular volume; LUSC cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs1178968 1.000 rs2353062 chr7:72740048 C/T cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.84e-13 Triglyceride levels; LUSC cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -6.91 -0.35 2.48e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg21782813 chr7:2030301 MAD1L1 0.5 8.62 0.43 2.68e-16 Bipolar disorder and schizophrenia; LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.96 0.36 1.85e-11 Platelet count; LUSC cis rs4786125 0.587 rs6500861 chr16:6923966 A/G cg03623568 chr16:6915990 A2BP1 -0.5 -8.41 -0.42 1.22e-15 Heart rate variability traits (SDNN); LUSC cis rs80282103 0.867 rs12241632 chr10:1069070 A/T cg08668510 chr10:1095578 IDI1 0.64 6.1 0.32 2.97e-9 Glomerular filtration rate (creatinine); LUSC cis rs1639906 0.507 rs1004643 chr7:2185324 G/C cg14004847 chr7:1930337 MAD1L1 0.5 6.79 0.35 5.06e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs4243830 0.737 rs11122088 chr1:6603677 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -9.64 -0.47 1.4e-19 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14967899 chr8:26434689 DPYSL2 0.47 7.0 0.36 1.44e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.12 0.32 2.59e-9 Hip circumference adjusted for BMI; LUSC cis rs983392 0.679 rs1026253 chr11:60030556 G/A cg20284999 chr11:59952153 MS4A6A 0.37 6.09 0.32 3.02e-9 Alzheimer's disease (late onset); LUSC cis rs12421382 0.659 rs1837397 chr11:109389803 A/C cg27471124 chr11:109292789 C11orf87 0.42 7.37 0.37 1.31e-12 Schizophrenia; LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg26354017 chr1:205819088 PM20D1 0.8 13.78 0.6 1.56e-34 Menarche (age at onset); LUSC cis rs983392 0.709 rs1349667 chr11:59993346 T/A cg02771260 chr11:59836817 MS4A3 -0.35 -5.69 -0.3 2.83e-8 Alzheimer's disease (late onset); LUSC cis rs8112211 0.911 rs2286476 chr19:38850759 G/A cg14299480 chr19:38876666 GGN -0.36 -6.13 -0.32 2.48e-9 Blood protein levels; LUSC cis rs7267979 1.000 rs6050632 chr20:25432601 A/G cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg18479299 chr3:125709523 NA -0.5 -5.68 -0.3 2.86e-8 Blood pressure (smoking interaction); LUSC cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg00677455 chr12:58241039 CTDSP2 0.61 9.13 0.45 6.64e-18 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg17376030 chr22:41985996 PMM1 -0.47 -5.99 -0.31 5.44e-9 Vitiligo; LUSC cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg03517284 chr6:25882590 NA -0.52 -9.66 -0.47 1.25e-19 Blood metabolite levels; LUSC cis rs9811920 0.809 rs793475 chr3:99543764 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -7.25 -0.37 2.94e-12 Axial length; LUSC cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg00530320 chr1:46809349 NSUN4 0.57 9.0 0.44 1.7e-17 Menopause (age at onset); LUSC cis rs2219968 1.000 rs33987699 chr8:78953437 A/C cg00738934 chr8:78996279 NA 0.37 6.67 0.34 1.05e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9420 0.961 rs71484461 chr11:57488890 G/A cg23127183 chr11:57508653 C11orf31 -0.58 -8.91 -0.44 3.41e-17 Schizophrenia; LUSC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.23e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs11153147 0.649 rs11153145 chr6:109300799 C/T cg05315195 chr6:109294784 ARMC2 -0.56 -6.19 -0.32 1.78e-9 Mean corpuscular volume; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs62408225 1.000 rs905670 chr6:90958502 G/A cg06866423 chr6:90926672 BACH2 0.41 5.86 0.31 1.08e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8072100 0.701 rs8075566 chr17:45771037 G/A cg08085267 chr17:45401833 C17orf57 -0.45 -6.63 -0.34 1.36e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3740713 1.000 rs2643872 chr11:18450444 A/T cg15463284 chr11:18477534 LDHAL6A -0.5 -5.87 -0.31 1.04e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.13 -0.32 2.49e-9 Lung cancer; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg16606324 chr3:10149918 C3orf24 0.57 8.34 0.42 1.98e-15 Alzheimer's disease; LUSC cis rs17253792 0.822 rs10147688 chr14:56054642 T/C cg01858014 chr14:56050164 KTN1 -0.86 -7.18 -0.37 4.47e-12 Putamen volume; LUSC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg08392591 chr16:89556376 ANKRD11 0.47 7.11 0.36 6.9e-12 Multiple myeloma (IgH translocation); LUSC cis rs11931598 0.513 rs3857170 chr4:7003366 A/T cg02503808 chr4:7069936 GRPEL1 0.44 6.51 0.34 2.72e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs4268898 0.662 rs59996104 chr2:24404064 C/T cg06627628 chr2:24431161 ITSN2 -0.86 -12.07 -0.55 4.48e-28 Asthma; LUSC cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg08999081 chr20:33150536 PIGU -0.48 -9.27 -0.45 2.38e-18 Glomerular filtration rate (creatinine); LUSC cis rs11077998 0.935 rs9893826 chr17:80511128 C/T cg10255544 chr17:80519551 FOXK2 0.38 6.25 0.32 1.23e-9 Reticulocyte fraction of red cells; LUSC cis rs6582630 0.615 rs3914894 chr12:38480280 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.28 -0.41 2.99e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs1008375 1.000 rs10939743 chr4:17662731 G/A cg18681998 chr4:17616180 MED28 0.86 15.64 0.65 9.61e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6120849 0.663 rs6119548 chr20:33552612 A/G cg24642439 chr20:33292090 TP53INP2 0.62 7.08 0.36 8.79e-12 Protein C levels; LUSC cis rs7572644 0.656 rs34096628 chr2:28060990 A/C cg27432699 chr2:27873401 GPN1 0.52 6.95 0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6977660 0.714 rs4719587 chr7:19828174 C/G cg05791153 chr7:19748676 TWISTNB 0.61 6.55 0.34 2.12e-10 Thyroid stimulating hormone; LUSC cis rs6977660 0.714 rs10251774 chr7:19790489 T/C cg05791153 chr7:19748676 TWISTNB 0.78 8.3 0.41 2.53e-15 Thyroid stimulating hormone; LUSC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg18357526 chr6:26021779 HIST1H4A 0.4 6.42 0.33 4.64e-10 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg10556349 chr10:835070 NA 0.58 6.27 0.32 1.14e-9 Eosinophil percentage of granulocytes; LUSC cis rs7923609 0.846 rs10761739 chr10:65062008 C/G cg01631684 chr10:65280961 REEP3 0.38 5.64 0.3 3.56e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs1003719 0.742 rs8129231 chr21:38501034 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs12540874 0.663 rs1451371 chr7:50553051 T/C cg18232548 chr7:50535776 DDC -0.64 -9.74 -0.47 6.91e-20 Systemic sclerosis; LUSC cis rs709400 0.628 rs7155014 chr14:103863970 C/G cg10523860 chr14:103875565 MARK3 -0.38 -6.16 -0.32 2.1e-9 Body mass index; LUSC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.37 5.71 0.3 2.52e-8 Menarche (age at onset); LUSC cis rs17253792 0.822 rs78261053 chr14:56061784 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg04317338 chr11:64019027 PLCB3 0.69 7.79 0.39 8.29e-14 Mean platelet volume; LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13126279 chr21:47581558 C21orf56 -0.56 -8.56 -0.42 4.09e-16 Testicular germ cell tumor; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg10360139 chr7:1886902 MAD1L1 -0.39 -5.96 -0.31 6.51e-9 Bipolar disorder and schizophrenia; LUSC cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.72 -0.3 2.31e-8 Bipolar disorder; LUSC trans rs12579753 0.871 rs12822050 chr12:82183041 C/T cg07923666 chr12:49932857 KCNH3 -0.49 -6.09 -0.32 3.03e-9 Resting heart rate; LUSC cis rs9837602 1.000 rs9878931 chr3:99712634 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.17 0.32 1.96e-9 Breast cancer; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04903157 chr22:35795952 MCM5 -0.42 -6.41 -0.33 4.9e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg17178900 chr1:205818956 PM20D1 0.94 18.84 0.72 1.87e-54 Menarche (age at onset); LUSC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg26441486 chr22:50317300 CRELD2 -0.54 -8.25 -0.41 3.75e-15 Schizophrenia; LUSC cis rs72772090 0.908 rs6864233 chr5:96044681 A/G cg17330273 chr5:96107758 CAST;ERAP1 0.58 7.03 0.36 1.13e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9549260 0.753 rs61963264 chr13:41154792 G/A cg21288729 chr13:41239152 FOXO1 0.54 6.19 0.32 1.72e-9 Red blood cell count; LUSC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg05535760 chr7:792225 HEATR2 0.89 9.42 0.46 7.79e-19 Cerebrospinal P-tau181p levels; LUSC cis rs12681288 0.523 rs111782857 chr8:962486 T/C cg04851639 chr8:1020857 NA -0.4 -8.05 -0.4 1.45e-14 Schizophrenia; LUSC cis rs17213078 0.510 rs17032713 chr2:106886839 T/C cg16099169 chr2:106886729 NA -0.43 -6.32 -0.33 8.29e-10 Facial morphology (factor 23); LUSC cis rs7178375 0.607 rs34178381 chr15:31222585 G/C cg15020726 chr15:31196382 MTMR15 0.91 7.64 0.39 2.3e-13 Hypertriglyceridemia; LUSC cis rs4919694 1.000 rs10509760 chr10:104634107 A/G cg04362960 chr10:104952993 NT5C2 1.12 13.36 0.59 6.58e-33 Arsenic metabolism; LUSC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.55 0.34 2.21e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6696846 0.765 rs4394715 chr1:205108393 T/G cg00857998 chr1:205179979 DSTYK 0.65 10.27 0.49 1.09e-21 Red blood cell count; LUSC trans rs9944715 1.000 rs4890633 chr18:43833278 C/T cg01718231 chr17:29326311 RNF135 -0.48 -6.87 -0.35 3.1e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs208520 0.661 rs7766144 chr6:66827795 C/T cg07460842 chr6:66804631 NA -1.15 -18.3 -0.71 2.71e-52 Exhaled nitric oxide output; LUSC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg08975724 chr8:8085496 FLJ10661 0.62 9.24 0.45 2.86e-18 Neuroticism; LUSC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.78 0.3 1.76e-8 Personality dimensions; LUSC cis rs11764590 0.694 rs4721359 chr7:2104951 A/G cg02825527 chr7:2087843 MAD1L1 -0.45 -5.85 -0.3 1.17e-8 Neuroticism; LUSC trans rs7824557 0.527 rs2736305 chr8:11237773 T/C cg08975724 chr8:8085496 FLJ10661 -0.42 -6.17 -0.32 1.99e-9 Retinal vascular caliber; LUSC cis rs2708377 0.858 rs117212341 chr12:11282556 C/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.81 7.9 0.4 4.08e-14 Bitter taste perception; LUSC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -7.24 -0.37 3.11e-12 Developmental language disorder (linguistic errors); LUSC trans rs6011368 0.678 rs6089801 chr20:62911391 T/G cg13869341 chr1:15865 WASH5P 0.39 6.03 0.31 4.34e-9 Clozapine-induced cytotoxicity; LUSC trans rs7824557 0.564 rs2736288 chr8:11228100 G/A cg15556689 chr8:8085844 FLJ10661 -0.56 -8.53 -0.42 5.31e-16 Retinal vascular caliber; LUSC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg02423579 chr7:2872169 GNA12 -0.38 -5.91 -0.31 8.49e-9 Height; LUSC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg00908189 chr16:619842 PIGQ 0.66 10.29 0.49 9.09e-22 Height; LUSC cis rs9527 0.615 rs2152915 chr10:104691732 A/T cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.46 1.42e-18 Arsenic metabolism; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02603192 chr20:25677290 ZNF337 -0.4 -6.12 -0.32 2.58e-9 Electrocardiographic conduction measures; LUSC cis rs4631830 0.900 rs7914347 chr10:51537431 C/T cg20129853 chr10:51489980 NA -0.34 -6.82 -0.35 4.29e-11 Prostate-specific antigen levels; LUSC cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg01256987 chr12:42539512 GXYLT1 -0.45 -8.52 -0.42 5.65e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg16339924 chr4:17578868 LAP3 0.63 9.23 0.45 3.22e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg00750074 chr16:89608354 SPG7 -0.56 -10.16 -0.49 2.61e-21 Multiple myeloma (IgH translocation); LUSC cis rs9325144 0.505 rs901635 chr12:38646572 A/C cg26384229 chr12:38710491 ALG10B -0.81 -13.11 -0.58 5.9e-32 Morning vs. evening chronotype; LUSC trans rs9944715 0.859 rs73425119 chr18:43753831 G/C cg01718231 chr17:29326311 RNF135 0.53 7.58 0.38 3.52e-13 Red cell distribution width;Mean corpuscular volume; LUSC trans rs877282 0.945 rs10904554 chr10:786768 T/C cg22713356 chr15:30763199 NA 1.09 15.49 0.65 3.65e-41 Uric acid levels; LUSC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs9640161 0.830 rs1051764 chr7:150070663 T/C cg17279839 chr7:150038598 RARRES2 0.36 5.87 0.31 1.06e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs10911232 0.507 rs10797821 chr1:183012559 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.67e-24 Hypertriglyceridemia; LUSC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg08132940 chr7:1081526 C7orf50 -0.49 -6.16 -0.32 2.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2228479 0.681 rs7199685 chr16:89959805 G/C cg06558623 chr16:89946397 TCF25 0.85 9.17 0.45 4.82e-18 Skin colour saturation; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.92 0.66 7.26e-43 Platelet count; LUSC cis rs11190604 1.000 rs2489043 chr10:102334327 T/C cg07080220 chr10:102295463 HIF1AN 0.66 9.22 0.45 3.46e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg08999081 chr20:33150536 PIGU 0.5 10.02 0.48 7.63e-21 Glomerular filtration rate (creatinine); LUSC cis rs10927875 0.619 rs12121764 chr1:16138059 A/T cg21385522 chr1:16154831 NA -0.59 -9.77 -0.47 5.31e-20 Dilated cardiomyopathy; LUSC cis rs1322512 0.752 rs1407489 chr6:152941182 G/T cg27316956 chr6:152958899 SYNE1 -0.36 -5.89 -0.31 9.48e-9 Tonometry; LUSC cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg13319975 chr6:146136371 FBXO30 0.48 7.33 0.37 1.76e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7727544 0.716 rs11949055 chr5:131576737 T/C cg09877947 chr5:131593287 PDLIM4 0.38 6.25 0.32 1.27e-9 Blood metabolite levels; LUSC cis rs244731 0.920 rs244707 chr5:176555636 A/T cg17509989 chr5:176798049 RGS14 0.66 8.72 0.43 1.3e-16 Urate levels in lean individuals; LUSC cis rs752010 0.695 rs12134166 chr1:42105867 C/T cg06885757 chr1:42089581 HIVEP3 0.44 8.48 0.42 7.29e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9527 0.545 rs10218853 chr10:104796787 A/C cg05855489 chr10:104503620 C10orf26 0.52 8.09 0.4 1.13e-14 Arsenic metabolism; LUSC cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg18252515 chr7:66147081 NA -1.19 -12.67 -0.57 2.71e-30 Diabetic kidney disease; LUSC cis rs7937682 0.924 rs12791699 chr11:111505880 T/C cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs7712401 0.755 rs1545696 chr5:122102442 A/G cg19077854 chr5:122220652 SNX24 0.32 7.02 0.36 1.27e-11 Mean platelet volume; LUSC trans rs459571 0.959 rs410876 chr9:136893867 C/A cg10765909 chr12:53715428 AAAS -0.43 -6.21 -0.32 1.54e-9 Platelet distribution width; LUSC cis rs7824557 0.545 rs34482136 chr8:11227885 C/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.36 -0.33 6.57e-10 Retinal vascular caliber; LUSC cis rs868036 0.718 rs28463100 chr15:68078769 T/C cg27219399 chr15:67835830 MAP2K5 0.34 5.66 0.3 3.33e-8 Restless legs syndrome; LUSC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg02423579 chr7:2872169 GNA12 -0.45 -6.59 -0.34 1.75e-10 Height; LUSC cis rs931127 0.502 rs1466462 chr11:65419364 C/G cg05805236 chr11:65401703 PCNXL3 0.63 10.91 0.51 6.47e-24 Systemic lupus erythematosus; LUSC cis rs9467773 1.000 rs1321479 chr6:26501897 C/T cg05738196 chr6:26577821 NA -0.75 -13.48 -0.59 2.37e-33 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.82 0.43 6.43e-17 Motion sickness; LUSC cis rs1559088 0.901 rs12610053 chr19:33582606 A/G cg03563238 chr19:33554763 RHPN2 -0.39 -6.25 -0.32 1.22e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3008870 1.000 rs1118393 chr1:67366668 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.27 0.64 2.6e-40 Lymphocyte percentage of white cells; LUSC cis rs763121 1.000 rs86796 chr22:38881454 A/C cg06022373 chr22:39101656 GTPBP1 -0.74 -11.63 -0.54 1.75e-26 Menopause (age at onset); LUSC cis rs208520 0.802 rs851600 chr6:66893754 T/C cg07460842 chr6:66804631 NA -1.06 -16.01 -0.66 3.32e-43 Exhaled nitric oxide output; LUSC cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg08999081 chr20:33150536 PIGU -0.42 -7.82 -0.39 6.91e-14 Glomerular filtration rate (creatinine); LUSC trans rs12145833 0.538 rs10926977 chr1:243411367 T/G cg01826367 chr1:224180288 NA 0.67 6.01 0.31 4.96e-9 Obesity (early onset extreme); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05261336 chr7:1032904 NA -0.4 -6.0 -0.31 5.17e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3125734 0.633 rs7100297 chr10:63985100 T/C cg09941381 chr10:64027924 RTKN2 -0.37 -6.93 -0.35 2.17e-11 Rheumatoid arthritis; LUSC cis rs317689 0.718 rs315130 chr12:69761444 T/C cg20891283 chr12:69753455 YEATS4 0.62 8.36 0.42 1.68e-15 Response to diuretic therapy; LUSC cis rs7246657 0.943 rs9304566 chr19:37845504 T/C cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC cis rs10911232 0.507 rs4652764 chr1:182994115 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 11.14 0.52 1.03e-24 Hypertriglyceridemia; LUSC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg01416388 chr22:39784598 NA -0.44 -7.21 -0.37 3.73e-12 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.93 16.59 0.67 1.63e-45 Chronic sinus infection; LUSC trans rs208520 0.909 rs9453672 chr6:66991431 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.79 0.54 4.45e-27 Exhaled nitric oxide output; LUSC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg06212747 chr3:49208901 KLHDC8B 0.45 6.08 0.32 3.37e-9 Parkinson's disease; LUSC cis rs4129585 1.000 rs4129585 chr8:143312933 A/C cg16886403 chr8:143471632 TSNARE1 0.45 6.4 0.33 5.2e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs6961069 0.645 rs10275699 chr7:80224709 G/A cg04458919 chr7:80252533 CD36 -0.41 -7.32 -0.37 1.91e-12 Platelet count; LUSC cis rs77956314 0.515 rs10850733 chr12:117380961 G/A cg02017074 chr12:117425053 FBXW8 0.67 7.71 0.39 1.47e-13 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs4319547 0.656 rs10734918 chr12:122921512 A/C cg23029597 chr12:123009494 RSRC2 -0.73 -9.17 -0.45 4.89e-18 Body mass index; LUSC trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg23505145 chr19:12996616 KLF1 0.63 10.56 0.5 1.14e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg00484396 chr16:3507460 NAT15 0.7 11.93 0.55 1.38e-27 Tuberculosis; LUSC cis rs2070488 0.775 rs2070489 chr3:38519424 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 12.35 0.56 4.1e-29 Electrocardiographic conduction measures; LUSC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg22029157 chr1:209979665 IRF6 -0.71 -10.57 -0.5 1.03e-22 Cleft lip with or without cleft palate; LUSC cis rs478304 0.651 rs11227299 chr11:65549570 C/G cg27068330 chr11:65405492 SIPA1 -0.79 -11.42 -0.53 1.03e-25 Acne (severe); LUSC cis rs1113500 0.933 rs11185260 chr1:108635079 A/T cg06207961 chr1:108661230 NA -0.4 -7.49 -0.38 6.09e-13 Growth-regulated protein alpha levels; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg25703541 chr22:24373054 LOC391322 -0.9 -16.1 -0.66 1.38e-43 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg08645402 chr16:4508243 NA 0.46 7.08 0.36 8.43e-12 Schizophrenia; LUSC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg23422044 chr7:1970798 MAD1L1 -0.59 -6.66 -0.34 1.11e-10 Bipolar disorder; LUSC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -7.98 -0.4 2.38e-14 Blood pressure (smoking interaction); LUSC cis rs72700829 0.576 rs6695311 chr1:151002758 G/A cg11822372 chr1:151115635 SEMA6C -0.75 -6.69 -0.34 9.53e-11 Schizophrenia; LUSC cis rs9905704 0.647 rs11659035 chr17:56966052 C/T cg12560992 chr17:57184187 TRIM37 0.59 9.51 0.46 4e-19 Testicular germ cell tumor; LUSC cis rs6494488 0.500 rs80142506 chr15:64995147 G/C cg08069370 chr15:64387884 SNX1 -0.68 -5.9 -0.31 8.97e-9 Coronary artery disease; LUSC cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.51 7.48 0.38 6.69e-13 Personality dimensions; LUSC cis rs7824557 0.527 rs2572376 chr8:11237756 C/A cg21775007 chr8:11205619 TDH -0.64 -9.97 -0.48 1.12e-20 Retinal vascular caliber; LUSC cis rs4363385 0.510 rs1500937 chr1:153045483 G/C cg25856811 chr1:152973957 SPRR3 -0.39 -6.37 -0.33 6.39e-10 Inflammatory skin disease; LUSC cis rs7851660 0.874 rs1955145 chr9:100634751 A/C cg13688889 chr9:100608707 NA 0.55 8.62 0.43 2.68e-16 Strep throat; LUSC cis rs870825 0.616 rs28497285 chr4:185629169 G/A cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg07362569 chr17:61921086 SMARCD2 -0.37 -7.54 -0.38 4.45e-13 Prudent dietary pattern; LUSC trans rs12043259 0.730 rs2208843 chr1:204789624 A/G cg05134015 chr14:36973365 SFTA3 0.5 5.97 0.31 5.99e-9 Addiction; LUSC cis rs2050392 0.931 rs2265187 chr10:30690844 C/T cg18806716 chr10:30721971 MAP3K8 -0.44 -7.14 -0.36 5.8e-12 Inflammatory bowel disease; LUSC trans rs6089829 0.962 rs2277768 chr20:61666823 T/C cg13615516 chr5:77269221 NA 0.4 6.72 0.35 7.73e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs35110281 0.548 rs7276316 chr21:45029333 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.57 0.53 3.01e-26 Mean corpuscular volume; LUSC cis rs6939532 0.648 rs9379862 chr6:26370707 T/C cg14345882 chr6:26364793 BTN3A2 0.44 6.09 0.32 3.08e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg13560548 chr3:10150139 C3orf24 0.52 7.47 0.38 6.96e-13 Alzheimer's disease; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg25072359 chr17:41440525 NA 0.66 9.5 0.46 4.09e-19 Menopause (age at onset); LUSC cis rs7246967 0.673 rs2082445 chr19:22834587 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs17253792 0.915 rs28663681 chr14:56178820 A/T cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs9486719 0.857 rs4839833 chr6:96882069 T/C cg06623918 chr6:96969491 KIAA0776 0.8 11.59 0.54 2.38e-26 Migraine;Coronary artery disease; LUSC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg02569458 chr12:86230093 RASSF9 -0.48 -7.91 -0.4 3.71e-14 Major depressive disorder; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg13003239 chr3:49044627 WDR6 -0.48 -6.43 -0.33 4.42e-10 Cognitive function;Information processing speed; LUSC cis rs1419980 0.673 rs4883421 chr12:7774028 A/G cg10578777 chr12:7781093 NA 0.54 6.0 0.31 5.13e-9 HDL cholesterol levels; LUSC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg12311346 chr5:56204834 C5orf35 -0.65 -9.57 -0.46 2.49e-19 Coronary artery disease; LUSC cis rs7911264 1.000 rs7911264 chr10:94436851 C/T cg25093409 chr10:94429542 NA -0.39 -6.62 -0.34 1.41e-10 Inflammatory bowel disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06037631 chr2:74942369 NA 0.35 6.25 0.32 1.23e-9 Triglycerides; LUSC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg06287003 chr12:125626642 AACS -0.4 -6.13 -0.32 2.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg07148914 chr20:33460835 GGT7 -0.53 -8.1 -0.41 1.05e-14 Glomerular filtration rate (creatinine); LUSC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg22105103 chr4:187893119 NA 0.72 14.08 0.61 1.13e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs981844 0.735 rs111822747 chr4:154734629 G/C cg14289246 chr4:154710475 SFRP2 0.46 6.17 0.32 1.93e-9 Response to statins (LDL cholesterol change); LUSC cis rs9473147 0.516 rs7767350 chr6:47485126 C/T cg12968598 chr6:47444699 CD2AP 0.53 8.07 0.4 1.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs9886651 0.806 rs13280865 chr8:128781333 A/G cg07795030 chr8:128802207 NA -0.34 -6.27 -0.32 1.14e-9 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs859767 0.540 rs13424016 chr2:135406395 A/G cg12500956 chr2:135428796 TMEM163 -0.26 -5.99 -0.31 5.58e-9 Neuroticism; LUSC cis rs2688608 0.904 rs2675669 chr10:75653872 C/T cg23231163 chr10:75533350 FUT11 -0.36 -5.99 -0.31 5.42e-9 Inflammatory bowel disease; LUSC cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg04727924 chr7:799746 HEATR2 -0.53 -6.31 -0.33 8.76e-10 Cerebrospinal P-tau181p levels; LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg10802521 chr3:52805072 NEK4 -0.55 -8.84 -0.44 5.41e-17 Bipolar disorder; LUSC trans rs11039798 0.844 rs7126949 chr11:48972166 A/G cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs12579753 0.917 rs7132732 chr12:82206053 C/G cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs77633900 0.772 rs284905 chr15:76743345 C/T cg21673338 chr15:77095150 SCAPER -0.68 -5.94 -0.31 7.22e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.68 10.41 0.49 3.7e-22 Lymphocyte counts; LUSC cis rs11264799 0.603 rs7520627 chr1:157568371 A/T cg18268488 chr1:157545234 FCRL4 0.34 6.21 0.32 1.54e-9 IgA nephropathy; LUSC cis rs12310956 0.510 rs7302434 chr12:33886819 G/A cg06521331 chr12:34319734 NA -0.37 -6.19 -0.32 1.81e-9 Morning vs. evening chronotype; LUSC cis rs9653442 0.527 rs2164712 chr2:100745404 C/G cg22139774 chr2:100720529 AFF3 -0.41 -6.93 -0.35 2.14e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg00530320 chr1:46809349 NSUN4 0.55 8.46 0.42 8.29e-16 Menopause (age at onset); LUSC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg23791538 chr6:167370224 RNASET2 -0.41 -6.62 -0.34 1.44e-10 Crohn's disease; LUSC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg13854012 chr2:162103682 NA -0.45 -7.97 -0.4 2.58e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs9287719 0.967 rs4669599 chr2:10758029 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC trans rs6981523 0.500 rs4412337 chr8:11072020 C/T cg06636001 chr8:8085503 FLJ10661 0.54 7.69 0.39 1.69e-13 Neuroticism; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg06096824 chr1:51443952 NA 0.34 6.11 0.32 2.7e-9 Metabolite levels (Pyroglutamine); LUSC cis rs11048434 0.736 rs11048344 chr12:9122609 G/C cg13575925 chr12:9217583 LOC144571 0.35 6.41 0.33 4.95e-10 Sjögren's syndrome; LUSC cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg19508488 chr2:152266495 RIF1 0.56 8.6 0.43 3.16e-16 Lung cancer; LUSC cis rs1865721 0.917 rs62089506 chr18:73178913 A/G cg26385618 chr18:73139727 C18orf62 -0.48 -8.19 -0.41 5.65e-15 Intelligence; LUSC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg21951975 chr1:209979733 IRF6 -0.56 -7.23 -0.37 3.4e-12 Cleft lip with or without cleft palate; LUSC cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg13126279 chr21:47581558 C21orf56 -0.43 -6.34 -0.33 7.48e-10 Testicular germ cell tumor; LUSC cis rs2279817 0.743 rs12023874 chr1:18025612 A/G cg21791023 chr1:18019539 ARHGEF10L 0.49 6.97 0.36 1.74e-11 Neuroticism; LUSC cis rs9467773 0.935 rs1884947 chr6:26553273 G/T cg12292205 chr6:26970375 C6orf41 0.36 5.72 0.3 2.38e-8 Intelligence (multi-trait analysis); LUSC trans rs2963482 0.691 rs2963440 chr5:157942696 G/T cg04221764 chr5:177410766 NA 0.33 6.41 0.33 4.83e-10 Nonsyndromic cleft lip with or without cleft palate; LUSC cis rs9653442 0.545 rs11681966 chr2:100759457 A/C cg07810366 chr2:100720526 AFF3 0.44 7.46 0.38 7.36e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg27432699 chr2:27873401 GPN1 -0.58 -8.46 -0.42 8.46e-16 Total body bone mineral density; LUSC cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg26384229 chr12:38710491 ALG10B -0.81 -14.09 -0.61 9.99e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg15423357 chr2:25149977 NA 0.45 9.13 0.45 6.59e-18 Body mass index; LUSC cis rs2404602 0.692 rs36070630 chr15:76949259 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.13 0.36 6.07e-12 Blood metabolite levels; LUSC cis rs4555082 1.000 rs7149013 chr14:105759840 T/C cg10792982 chr14:105748885 BRF1 0.49 8.48 0.42 7.31e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg26513180 chr16:89883248 FANCA 0.92 17.5 0.69 3.99e-49 Vitiligo; LUSC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 7.19 0.37 4.39e-12 Platelet count; LUSC trans rs12709013 0.636 rs1646269 chr16:58777316 T/C cg19313373 chr1:162694184 DDR2 -0.35 -5.96 -0.31 6.55e-9 Blood metabolite ratios; LUSC cis rs7267979 0.844 rs2257649 chr20:25263457 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.77 15.99 0.66 4.06e-43 Liver enzyme levels (alkaline phosphatase); LUSC cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg21573476 chr21:45109991 RRP1B -0.43 -6.94 -0.36 2.04e-11 Mean corpuscular volume; LUSC cis rs1143633 0.566 rs2708932 chr2:113690675 C/A cg06156847 chr2:113672199 IL1F7 0.3 6.34 0.33 7.45e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs208520 0.526 rs6455072 chr6:66797215 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.21 -25.6 -0.81 9.6e-81 Exhaled nitric oxide output; LUSC cis rs888194 0.544 rs2196612 chr12:109849535 A/G cg05360138 chr12:110035743 NA 0.4 5.88 0.31 9.84e-9 Neuroticism; LUSC cis rs778371 0.874 rs938575 chr2:233768788 G/A cg08000102 chr2:233561755 GIGYF2 -0.64 -8.4 -0.42 1.27e-15 Schizophrenia; LUSC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.02 0.4 1.84e-14 Axial length; LUSC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg11764359 chr7:65958608 NA -0.7 -10.95 -0.51 4.95e-24 Aortic root size; LUSC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg05623727 chr3:50126028 RBM5 -0.34 -6.52 -0.34 2.57e-10 Intelligence (multi-trait analysis); LUSC cis rs2573652 0.722 rs8034841 chr15:100541593 G/T cg09918751 chr15:100517450 ADAMTS17 -0.3 -5.65 -0.3 3.52e-8 Height; LUSC trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -6.67 -0.34 1.06e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg02569458 chr12:86230093 RASSF9 0.47 7.41 0.38 1.05e-12 Major depressive disorder; LUSC cis rs11971779 0.715 rs6954219 chr7:139065110 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs8038465 0.638 rs12591473 chr15:73967485 A/T cg15420318 chr15:73925796 NPTN 0.54 9.63 0.47 1.56e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10754283 0.967 rs6428559 chr1:90099036 C/T cg21401794 chr1:90099060 LRRC8C 0.65 9.76 0.47 5.75e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs11677416 1.000 rs4848304 chr2:113552737 T/C cg27083787 chr2:113543245 IL1A 0.47 7.33 0.37 1.79e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg00071950 chr4:10020882 SLC2A9 0.6 10.11 0.48 4.01e-21 Bone mineral density; LUSC cis rs1670533 1.000 rs1670534 chr4:1087265 T/C cg16405210 chr4:1374714 KIAA1530 -0.47 -5.7 -0.3 2.67e-8 Recombination rate (females); LUSC cis rs11190604 1.000 rs4244338 chr10:102272802 A/G cg16342193 chr10:102329863 NA -0.37 -6.8 -0.35 4.82e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.41e-28 Motion sickness; LUSC cis rs72781680 1.000 rs72788278 chr2:24095285 A/C cg20701182 chr2:24300061 SF3B14 0.56 6.05 0.31 3.84e-9 Lymphocyte counts; LUSC cis rs950776 0.722 rs471889 chr15:78870235 T/C cg06917634 chr15:78832804 PSMA4 -0.68 -10.99 -0.52 3.42e-24 Sudden cardiac arrest; LUSC cis rs11190604 1.000 rs11292 chr10:102313607 A/G cg16342193 chr10:102329863 NA -0.35 -6.48 -0.33 3.28e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg17971929 chr21:40555470 PSMG1 0.8 14.07 0.61 1.2e-35 Cognitive function; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21767207 chr19:36236454 PSENEN;U2AF1L4 -0.5 -6.82 -0.35 4.29e-11 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.64 0.34 1.26e-10 Lung cancer; LUSC cis rs7829975 0.572 rs28730413 chr8:8795447 A/C cg15556689 chr8:8085844 FLJ10661 -0.59 -9.91 -0.48 1.88e-20 Mood instability; LUSC cis rs7843479 0.930 rs4871903 chr8:21827833 C/T cg17168535 chr8:21777572 XPO7 -0.65 -9.93 -0.48 1.53e-20 Mean corpuscular volume; LUSC cis rs1395 0.922 rs11898114 chr2:27515527 C/T cg23587288 chr2:27483067 SLC30A3 -0.3 -5.81 -0.3 1.46e-8 Blood metabolite levels; LUSC cis rs644799 0.710 rs3017756 chr11:95537358 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.86 0.6 8.34e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11030122 0.702 rs10835340 chr11:3960420 A/G cg08557956 chr11:4115526 RRM1 0.47 6.04 0.31 4.07e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs1003719 0.715 rs8128387 chr21:38556787 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.41 -0.49 3.71e-22 Eye color traits; LUSC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg25019033 chr10:957182 NA -0.5 -6.2 -0.32 1.69e-9 Eosinophil percentage of granulocytes; LUSC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg24399712 chr22:39784796 NA -0.63 -11.31 -0.53 2.41e-25 Intelligence (multi-trait analysis); LUSC cis rs9434723 0.844 rs9435148 chr1:9300962 G/C cg04199779 chr1:9294473 H6PD 0.51 5.97 0.31 6.12e-9 Height; LUSC cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.5 0.42 6.52e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs739496 0.542 rs7312913 chr12:111793552 A/G cg10833066 chr12:111807467 FAM109A 0.62 12.05 0.55 5.06e-28 Platelet count; LUSC cis rs11264799 0.520 rs849817 chr1:157542045 G/A cg18268488 chr1:157545234 FCRL4 0.38 7.53 0.38 4.67e-13 IgA nephropathy; LUSC cis rs8072100 0.905 rs9901869 chr17:45575206 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.37 -6.12 -0.32 2.57e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.39 0.49 4.15e-22 Schizophrenia; LUSC trans rs12080794 1.000 rs11121322 chr1:9155410 G/A cg11315153 chr6:62996299 KHDRBS2 -0.52 -6.11 -0.32 2.76e-9 Response to antidepressant treatment (citalopram); LUSC cis rs10746514 1.000 rs9724948 chr1:232248244 C/T cg09506761 chr1:232265262 NA 0.47 7.64 0.39 2.25e-13 Response to statin therapy; LUSC cis rs9463078 0.547 rs720576 chr6:44729974 A/T cg25276700 chr6:44698697 NA 0.3 6.3 0.33 9.28e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs11247915 0.561 rs12750420 chr1:26608649 G/A cg04990556 chr1:26633338 UBXN11 -0.53 -7.24 -0.37 3.15e-12 Obesity-related traits; LUSC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg21435336 chr19:17392852 ANKLE1 0.45 6.33 0.33 7.76e-10 Systemic lupus erythematosus; LUSC cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg24324837 chr19:49891574 CCDC155 0.5 7.08 0.36 8.33e-12 Multiple sclerosis; LUSC cis rs79518236 1 rs79518236 chr7:98026554 ACT/A cg09267113 chr7:98030324 BAIAP2L1 -0.77 -11.0 -0.52 3.19e-24 Breast cancer; LUSC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg18876405 chr7:65276391 NA -0.66 -11.66 -0.54 1.34e-26 Aortic root size; LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.25 0.37 2.83e-12 Bipolar disorder; LUSC cis rs4925386 0.559 rs2427291 chr20:60921324 G/A cg06026331 chr20:60912101 LAMA5 0.59 6.32 0.33 8.17e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg20243544 chr17:37824526 PNMT 0.49 6.95 0.36 1.92e-11 Asthma; LUSC trans rs61931739 0.500 rs7308338 chr12:34553181 A/G cg13010199 chr12:38710504 ALG10B 0.57 8.94 0.44 2.68e-17 Morning vs. evening chronotype; LUSC cis rs9906944 0.707 rs9912906 chr17:47104432 A/T cg14634687 chr17:47094252 IGF2BP1 0.31 6.54 0.34 2.26e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg02807482 chr3:125708958 NA -0.54 -6.74 -0.35 6.88e-11 Blood pressure (smoking interaction); LUSC cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg08807101 chr21:30365312 RNF160 0.58 8.84 0.44 5.47e-17 Selective IgA deficiency; LUSC cis rs7208859 0.623 rs9915566 chr17:29132158 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs57994353 0.568 rs10870151 chr9:139309584 G/A cg14019695 chr9:139328340 INPP5E 0.37 5.79 0.3 1.67e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; LUSC cis rs9287719 0.967 rs6432113 chr2:10744889 C/T cg00105475 chr2:10696890 NA -0.38 -6.4 -0.33 5.4e-10 Prostate cancer; LUSC cis rs9359856 0.564 rs17584108 chr6:90458209 T/C cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.2 -0.41 5.08e-15 Bipolar disorder; LUSC cis rs500891 0.525 rs12213724 chr6:84078990 A/C cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg12292205 chr6:26970375 C6orf41 -0.55 -6.71 -0.34 8.34e-11 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.697 rs4560394 chr4:120313435 T/G cg25214090 chr10:38739885 LOC399744 0.55 8.04 0.4 1.62e-14 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G ch.20.661824R chr20:32868459 AHCY 0.45 6.23 0.32 1.41e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00032686 chr4:1005072 FGFRL1 -0.42 -6.62 -0.34 1.45e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.46 0.38 7.77e-13 Motion sickness; LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg18404041 chr3:52824283 ITIH1 -0.55 -10.5 -0.5 1.79e-22 Bipolar disorder; LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08532152 chr11:10772778 CTR9 0.78 6.09 0.32 3.05e-9 Cognitive performance; LUSC cis rs7481584 0.624 rs12417389 chr11:3035304 G/C cg08508325 chr11:3079039 CARS 0.35 7.85 0.39 5.9e-14 Calcium levels; LUSC cis rs3809863 0.602 rs6504833 chr17:45396087 A/G cg25173405 chr17:45401733 C17orf57 -0.48 -7.13 -0.36 6.14e-12 Glaucoma (primary open-angle); LUSC cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg15839431 chr19:19639596 YJEFN3 0.6 6.75 0.35 6.71e-11 Bipolar disorder; LUSC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg26695010 chr11:65641043 EFEMP2 -0.44 -6.65 -0.34 1.2e-10 Eosinophil percentage of white cells; LUSC cis rs4423214 0.559 rs10898203 chr11:71203436 C/T cg05163923 chr11:71159392 DHCR7 -0.7 -7.23 -0.37 3.32e-12 Vitamin D levels; LUSC cis rs7618501 1.000 rs7372730 chr3:49790682 C/G cg24110177 chr3:50126178 RBM5 0.43 6.83 0.35 4.05e-11 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11890956 chr21:40555474 PSMG1 0.98 18.79 0.72 3e-54 Cognitive function; LUSC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg15691649 chr6:25882328 NA -0.5 -7.45 -0.38 7.99e-13 Blood metabolite levels; LUSC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.91 -0.44 3.36e-17 Breast cancer; LUSC cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs61332075 0.518 rs112649209 chr2:239422814 C/G cg18131467 chr2:239335373 ASB1 -0.68 -6.47 -0.33 3.41e-10 Lung function (FEV1/FVC); LUSC cis rs597583 0.950 rs473343 chr11:117408156 G/C cg27161313 chr11:117392002 DSCAML1 -0.38 -6.55 -0.34 2.11e-10 Putamen volume; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg05863683 chr7:1912471 MAD1L1 0.31 5.99 0.31 5.34e-9 Bipolar disorder and schizophrenia; LUSC cis rs11048434 0.736 rs1805733 chr12:9089272 A/C cg13575925 chr12:9217583 LOC144571 0.32 5.75 0.3 2.03e-8 Sjögren's syndrome; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg27129171 chr3:47204927 SETD2 -0.68 -11.27 -0.52 3.58e-25 Colorectal cancer; LUSC cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg14458575 chr2:238380390 NA 0.74 13.37 0.59 6.16e-33 Prostate cancer; LUSC trans rs10506458 0.915 rs79133015 chr12:63396838 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -15.44 -0.65 5.73e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.93 -18.16 -0.7 9.41e-52 Prudent dietary pattern; LUSC cis rs6582630 0.638 rs12423236 chr12:38548162 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.41 -0.33 5.01e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.52 -8.51 -0.42 6.12e-16 Prudent dietary pattern; LUSC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg06636001 chr8:8085503 FLJ10661 -0.62 -9.5 -0.46 4.09e-19 Mood instability; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16236679 chr11:96123321 JRKL;CCDC82 0.42 6.08 0.32 3.34e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6754311 0.593 rs10195620 chr2:136495619 A/T cg25344623 chr2:136566232 LCT 0.38 5.72 0.3 2.41e-8 Mosquito bite size; LUSC cis rs796364 0.762 rs13030712 chr2:200973569 G/A cg17644776 chr2:200775616 C2orf69 0.4 6.14 0.32 2.37e-9 Schizophrenia; LUSC trans rs11098499 0.863 rs10030660 chr4:120436704 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.62 0.38 2.71e-13 Corneal astigmatism; LUSC cis rs782590 0.967 rs2627759 chr2:55853341 T/C cg03859395 chr2:55845619 SMEK2 0.88 16.63 0.67 1.14e-45 Metabolic syndrome; LUSC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg17971929 chr21:40555470 PSMG1 -0.68 -11.11 -0.52 1.31e-24 Cognitive function; LUSC cis rs8005677 0.828 rs2295680 chr14:23374435 A/G cg25600027 chr14:23388339 RBM23 0.4 6.24 0.32 1.36e-9 Cognitive ability (multi-trait analysis); LUSC cis rs73206853 0.563 rs1973505 chr12:111160003 A/G cg12870014 chr12:110450643 ANKRD13A -0.7 -9.08 -0.44 9.68e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.7 -0.57 2.02e-30 Chronic sinus infection; LUSC cis rs6977660 0.607 rs7357321 chr7:19817636 C/T cg05791153 chr7:19748676 TWISTNB 0.65 7.0 0.36 1.39e-11 Thyroid stimulating hormone; LUSC trans rs61931739 0.500 rs11053235 chr12:34507899 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.25e-22 Morning vs. evening chronotype; LUSC cis rs62158211 0.691 rs1964463 chr2:114069021 C/T cg17784749 chr2:114082611 LOC440839 -0.45 -5.89 -0.31 9.18e-9 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; LUSC cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg01689657 chr7:91764605 CYP51A1 0.32 5.83 0.3 1.32e-8 Breast cancer; LUSC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg05802129 chr4:122689817 NA -0.34 -6.0 -0.31 5.17e-9 Type 2 diabetes; LUSC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.57 8.41 0.42 1.17e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.67 0.34 1.06e-10 Menopause (age at onset); LUSC cis rs1577917 0.771 rs2783171 chr6:86382765 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.59 0.43 3.48e-16 Response to antipsychotic treatment; LUSC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg18190219 chr22:46762943 CELSR1 -0.49 -6.08 -0.32 3.2e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs10779751 0.734 rs2259886 chr1:11137778 C/T cg08854313 chr1:11322531 MTOR 0.81 12.51 0.57 9.9e-30 Body mass index; LUSC cis rs1950626 0.833 rs67456801 chr14:101399169 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.39 6.84 0.35 3.71e-11 Pelvic organ prolapse (moderate/severe); LUSC trans rs3929778 0.848 rs2326793 chr20:6541381 C/G cg26955290 chr17:7015607 ASGR2 -0.41 -6.19 -0.32 1.73e-9 QRS complex (Cornell); LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg11645453 chr3:52864694 ITIH4 0.35 8.05 0.4 1.43e-14 Bipolar disorder; LUSC cis rs9814567 0.896 rs10935123 chr3:134345327 C/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -5.77 -0.3 1.84e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg05368731 chr17:41323189 NBR1 0.83 13.66 0.6 4.78e-34 Menopause (age at onset); LUSC cis rs11997175 0.646 rs7464237 chr8:33716596 C/T ch.8.33884649F chr8:33765107 NA 0.46 7.0 0.36 1.44e-11 Body mass index; LUSC cis rs8077889 0.956 rs17742347 chr17:41846468 A/G cg26893861 chr17:41843967 DUSP3 -0.97 -15.16 -0.64 6.95e-40 Triglycerides; LUSC cis rs1577917 0.958 rs16876530 chr6:86595641 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.17 -0.32 1.96e-9 Response to antipsychotic treatment; LUSC cis rs2635047 0.811 rs12958943 chr18:44786818 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 5.7 0.3 2.68e-8 Educational attainment; LUSC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg26762873 chr11:5879799 OR52E8 -0.3 -5.94 -0.31 7.25e-9 DNA methylation (variation); LUSC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.89 -0.35 2.82e-11 Breast cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00658016 chr3:178865678 PIK3CA -0.4 -5.94 -0.31 7.01e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs1997103 1.000 rs4948011 chr7:55403859 A/G cg20935933 chr6:143382018 AIG1 0.48 7.19 0.37 4.23e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1577917 1.000 rs12199784 chr6:86726808 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.22 -0.41 4.54e-15 Response to antipsychotic treatment; LUSC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg02574844 chr11:5959923 NA -0.4 -5.96 -0.31 6.27e-9 DNA methylation (variation); LUSC cis rs7760949 0.925 rs9464420 chr6:13925892 C/T cg27413430 chr6:13925136 RNF182 0.61 9.04 0.44 1.33e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg06637938 chr14:75390232 RPS6KL1 0.5 7.74 0.39 1.2e-13 Height; LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06657462 chr10:94608040 EXOC6 0.5 6.67 0.34 1.05e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.78 -0.3 1.73e-8 Alzheimer's disease (late onset); LUSC cis rs72781680 1.000 rs72781665 chr2:24223086 G/A cg08917208 chr2:24149416 ATAD2B 0.9 10.16 0.49 2.67e-21 Lymphocyte counts; LUSC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg26441486 chr22:50317300 CRELD2 -0.54 -8.21 -0.41 4.86e-15 Schizophrenia; LUSC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.51 0.34 2.77e-10 Schizophrenia; LUSC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs4363385 0.747 rs10494285 chr1:152982285 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.33e-13 Inflammatory skin disease; LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg08200582 chr11:442649 ANO9 -0.57 -6.07 -0.32 3.53e-9 Body mass index; LUSC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg25456477 chr12:86230367 RASSF9 0.35 6.25 0.32 1.24e-9 Major depressive disorder; LUSC cis rs7258465 0.897 rs1043327 chr19:18554972 A/G cg11102782 chr19:18549136 ISYNA1 -0.35 -6.62 -0.34 1.44e-10 Breast cancer; LUSC cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg09184832 chr6:79620586 NA -0.41 -6.32 -0.33 8.39e-10 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.44 0.38 8.39e-13 Schizophrenia; LUSC cis rs7100689 0.556 rs3120976 chr10:82025682 C/A cg00277334 chr10:82204260 NA -0.41 -5.76 -0.3 1.89e-8 Post bronchodilator FEV1; LUSC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg24733560 chr20:60626293 TAF4 0.42 7.75 0.39 1.11e-13 Body mass index; LUSC cis rs262150 0.536 rs73167296 chr7:158783129 C/T cg19418458 chr7:158789849 NA 0.49 6.44 0.33 4.24e-10 Facial morphology (factor 20); LUSC cis rs1577917 0.652 rs75593931 chr6:86719539 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.01 -0.36 1.31e-11 Response to antipsychotic treatment; LUSC cis rs3540 0.574 rs2601205 chr15:90961813 A/G cg10434728 chr15:90938212 IQGAP1 0.4 8.36 0.42 1.7e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg16325326 chr1:53192061 ZYG11B 0.69 11.22 0.52 5.1e-25 Monocyte count; LUSC cis rs13072153 0.793 rs9841477 chr3:123157477 A/C cg04138502 chr3:123167522 ADCY5 0.28 5.72 0.3 2.39e-8 Chronic kidney disease; LUSC cis rs72781680 0.848 rs6748727 chr2:24041058 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg19346786 chr7:2764209 NA -0.52 -8.63 -0.43 2.5e-16 Height; LUSC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg16060761 chr17:80687452 NA 0.42 7.07 0.36 8.83e-12 Breast cancer; LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.7 11.28 0.53 3.31e-25 Prudent dietary pattern; LUSC cis rs1691799 0.899 rs1168320 chr12:66744849 C/T cg16791601 chr12:66731901 HELB -0.71 -12.51 -0.56 1.04e-29 White blood cell count (basophil); LUSC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg16606324 chr3:10149918 C3orf24 0.44 6.83 0.35 4.05e-11 Alzheimer's disease; LUSC cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs2797160 0.651 rs1268092 chr6:126029043 A/G cg05901451 chr6:126070800 HEY2 -0.77 -12.61 -0.57 4.37e-30 Endometrial cancer; LUSC cis rs61897795 0.657 rs174590 chr11:61616977 G/C cg19610905 chr11:61596333 FADS2 -0.44 -5.76 -0.3 1.88e-8 Neutrophil count;Sum basophil neutrophil counts; LUSC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg15704280 chr7:45808275 SEPT13 1.03 17.92 0.7 8.94e-51 Coronary artery disease; LUSC cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg08999081 chr20:33150536 PIGU 0.45 8.29 0.41 2.85e-15 Coronary artery disease; LUSC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg05313129 chr8:58192883 C8orf71 -0.5 -6.5 -0.34 2.9e-10 Developmental language disorder (linguistic errors); LUSC cis rs8014204 0.870 rs3742790 chr14:75308758 C/T cg06637938 chr14:75390232 RPS6KL1 -0.64 -10.93 -0.51 5.69e-24 Caffeine consumption; LUSC cis rs2249625 0.526 rs17781511 chr6:72845455 C/T cg18830697 chr6:72922368 RIMS1 0.38 7.59 0.38 3.25e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs10197940 0.624 rs17270233 chr2:152372420 A/G cg19508488 chr2:152266495 RIF1 0.54 7.72 0.39 1.36e-13 Lung cancer; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg10360139 chr7:1886902 MAD1L1 0.44 6.94 0.35 2.1e-11 Bipolar disorder and schizophrenia; LUSC cis rs6545883 0.929 rs3732170 chr2:61749716 C/T cg15711740 chr2:61764176 XPO1 -0.5 -7.92 -0.4 3.51e-14 Tuberculosis; LUSC cis rs738322 0.934 rs84473 chr22:38557326 T/C cg17652424 chr22:38574118 PLA2G6 -0.31 -6.66 -0.34 1.15e-10 Cutaneous nevi; LUSC cis rs1153858 1.000 rs2467863 chr15:45641880 G/A cg26924012 chr15:45694286 SPATA5L1 1.15 20.83 0.75 2.5e-62 Homoarginine levels; LUSC cis rs7917772 0.505 rs61869211 chr10:104449836 A/G cg05855489 chr10:104503620 C10orf26 -0.65 -8.29 -0.41 2.8e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.03 -0.31 4.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg08742575 chr21:47604166 C21orf56 -0.42 -6.26 -0.32 1.2e-9 Testicular germ cell tumor; LUSC cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.92 0.7 8.72e-51 Chronic sinus infection; LUSC cis rs6964587 1.000 rs7784248 chr7:91758111 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.88 0.31 1e-8 Breast cancer; LUSC cis rs1728785 1.000 rs1170436 chr16:68607486 T/A cg02972257 chr16:68554789 NA -0.5 -6.18 -0.32 1.91e-9 Ulcerative colitis; LUSC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg15448220 chr1:150897856 SETDB1 0.4 5.89 0.31 9.64e-9 Melanoma; LUSC trans rs9467711 0.606 rs13212985 chr6:26609989 G/C cg06606381 chr12:133084897 FBRSL1 -0.81 -7.11 -0.36 7.29e-12 Autism spectrum disorder or schizophrenia; LUSC trans rs7824557 0.564 rs2437152 chr8:11235497 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.54 -0.34 2.27e-10 Retinal vascular caliber; LUSC cis rs4964805 0.657 rs11111781 chr12:104187440 C/T cg02344784 chr12:104178138 NT5DC3 0.46 8.9 0.44 3.55e-17 Attention deficit hyperactivity disorder; LUSC cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg14458575 chr2:238380390 NA 0.74 13.07 0.58 8.13e-32 Prostate cancer; LUSC cis rs2836633 0.929 rs8130434 chr21:40036243 C/T cg12884169 chr21:40033163 ERG -0.61 -12.66 -0.57 2.97e-30 Coronary artery disease; LUSC cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg23711669 chr6:146136114 FBXO30 0.92 17.68 0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs11971779 0.680 rs73154134 chr7:139039951 G/A cg07862535 chr7:139043722 LUC7L2 0.58 7.07 0.36 9.11e-12 Diisocyanate-induced asthma; LUSC cis rs25645 0.502 rs7223318 chr17:38108553 G/C cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -9.19 -0.45 4.25e-18 Myeloid white cell count; LUSC cis rs1881396 0.891 rs2141372 chr2:27827196 G/T cg27432699 chr2:27873401 GPN1 0.63 8.61 0.43 2.91e-16 Nonalcoholic fatty liver disease; LUSC trans rs12887734 0.546 rs12885509 chr14:104273325 T/C cg16487237 chr3:137487248 NA 0.36 6.02 0.31 4.69e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg04455712 chr21:45112962 RRP1B 0.42 7.96 0.4 2.77e-14 Mean corpuscular volume; LUSC cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg22117172 chr7:91764530 CYP51A1 0.32 5.68 0.3 2.88e-8 Breast cancer; LUSC cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg17330251 chr7:94953956 PON1 -0.39 -6.45 -0.33 3.93e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9300255 0.602 rs1716177 chr12:123655457 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.45 0.33 4.04e-10 Neutrophil percentage of white cells; LUSC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg27398817 chr8:82754497 SNX16 0.47 6.36 0.33 6.61e-10 Diastolic blood pressure; LUSC cis rs12579753 0.810 rs10862355 chr12:82162698 C/T cg21231944 chr12:82153410 PPFIA2 -0.36 -5.75 -0.3 2.04e-8 Resting heart rate; LUSC trans rs17607347 0.542 rs17609808 chr16:72568186 A/T cg12945194 chr11:64703312 GPHA2 0.38 5.95 0.31 6.73e-9 Intelligence (multi-trait analysis); LUSC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg17633681 chr16:88106987 BANP 0.53 10.16 0.49 2.64e-21 Menopause (age at onset); LUSC cis rs11039100 0.850 rs34930440 chr11:5834157 A/T cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs778371 0.722 rs778348 chr2:233802635 G/A cg08000102 chr2:233561755 GIGYF2 -0.52 -6.94 -0.36 2.03e-11 Schizophrenia; LUSC cis rs7267979 1.000 rs2424712 chr20:25416942 T/C cg08601574 chr20:25228251 PYGB 0.42 6.52 0.34 2.66e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.43 0.67 7.13e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg07817648 chr10:79422355 NA -0.56 -7.68 -0.39 1.77e-13 Bone mineral density; LUSC cis rs16866061 1.000 rs72974222 chr2:225424143 C/T cg12698349 chr2:225449008 CUL3 0.87 14.02 0.61 1.97e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg06636001 chr8:8085503 FLJ10661 0.67 10.75 0.51 2.42e-23 Mood instability; LUSC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.96e-31 Eye color traits; LUSC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg06008330 chr7:65541103 ASL -0.4 -6.23 -0.32 1.43e-9 Aortic root size; LUSC cis rs3859192 0.561 rs12451547 chr17:38181168 T/C cg17467752 chr17:38218738 THRA -0.52 -7.44 -0.38 8.46e-13 White blood cell count; LUSC cis rs1023500 0.551 rs2301521 chr22:42423110 G/C cg15557168 chr22:42548783 NA -0.42 -6.39 -0.33 5.57e-10 Schizophrenia; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg16325326 chr1:53192061 ZYG11B 0.69 11.17 0.52 7.98e-25 Monocyte count; LUSC trans rs12677056 0.739 rs62514398 chr8:113312090 G/T cg12159992 chr12:102059490 MYBPC1 0.36 6.01 0.31 4.84e-9 Peripheral artery disease; LUSC cis rs10740039 0.671 rs7913549 chr10:62418232 C/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.55e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs965604 1.000 rs12593229 chr15:78765290 T/G cg18825076 chr15:78729989 IREB2 -0.42 -6.78 -0.35 5.38e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6969780 0.908 rs6461987 chr7:27166956 G/C cg26364809 chr7:27145159 NA -0.58 -5.86 -0.31 1.09e-8 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs4595586 0.525 rs7972595 chr12:39338000 G/A cg26384229 chr12:38710491 ALG10B 0.57 7.98 0.4 2.43e-14 Morning vs. evening chronotype; LUSC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg26429629 chr5:169758391 LOC257358 0.43 7.3 0.37 2.16e-12 Schizophrenia; LUSC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.51 0.34 2.73e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg18681998 chr4:17616180 MED28 0.9 17.84 0.7 1.85e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs611744 0.538 rs2298605 chr8:109272006 T/C cg18478394 chr8:109455254 TTC35 0.47 7.28 0.37 2.38e-12 Dupuytren's disease; LUSC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg00815214 chr21:47717953 NA 0.39 6.07 0.32 3.45e-9 Testicular germ cell tumor; LUSC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg20135002 chr11:47629003 NA -0.51 -8.02 -0.4 1.83e-14 Subjective well-being; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20530339 chr18:21594203 TTC39C 0.39 7.08 0.36 8.5e-12 Asthma; LUSC cis rs7598759 0.712 rs6740474 chr2:232331831 A/G cg19187155 chr2:232395269 NMUR1 0.49 7.2 0.37 3.96e-12 Noise-induced hearing loss; LUSC cis rs9916302 0.706 rs667193 chr17:37448835 T/C cg07936489 chr17:37558343 FBXL20 0.78 9.96 0.48 1.27e-20 Glomerular filtration rate (creatinine); LUSC cis rs9816226 0.587 rs9863591 chr3:185841624 C/G cg00760338 chr3:185826511 ETV5 -0.66 -10.63 -0.5 6.54e-23 Obesity;Body mass index; LUSC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg14583973 chr4:3374767 RGS12 -0.36 -7.85 -0.39 5.76e-14 Serum sulfate level; LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs1559088 0.895 rs1974784 chr19:33551563 T/G cg27124370 chr19:33622961 WDR88 0.51 6.68 0.34 1e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2839186 0.749 rs62226489 chr21:47710519 T/C cg12379764 chr21:47803548 PCNT -0.42 -5.91 -0.31 8.56e-9 Testicular germ cell tumor; LUSC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg09021430 chr5:549028 NA -0.53 -6.7 -0.34 8.73e-11 Lung disease severity in cystic fibrosis; LUSC cis rs4243830 0.850 rs12030607 chr1:6601007 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.88 10.54 0.5 1.31e-22 Body mass index; LUSC trans rs12579753 0.917 rs12822036 chr12:82183009 C/T cg07923666 chr12:49932857 KCNH3 -0.48 -5.96 -0.31 6.29e-9 Resting heart rate; LUSC cis rs500891 0.525 rs1535588 chr6:84051050 A/C cg08257003 chr6:84140564 ME1 0.33 7.98 0.4 2.44e-14 Platelet-derived growth factor BB levels; LUSC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg15145296 chr3:125709740 NA -0.57 -6.45 -0.33 3.94e-10 Blood pressure (smoking interaction); LUSC cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs3812762 0.912 rs4929936 chr11:8792622 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.37 -6.14 -0.32 2.37e-9 Hypospadias; LUSC cis rs4631830 0.863 rs10826125 chr10:51530505 G/A cg20129853 chr10:51489980 NA -0.34 -6.86 -0.35 3.36e-11 Prostate-specific antigen levels; LUSC cis rs9393692 0.902 rs6456711 chr6:26302572 A/C cg00631329 chr6:26305371 NA -0.49 -9.57 -0.46 2.41e-19 Educational attainment; LUSC cis rs1728785 1.000 rs1728764 chr16:68572292 G/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg07936489 chr17:37558343 FBXL20 0.71 9.96 0.48 1.21e-20 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg17366294 chr4:99064904 C4orf37 0.54 9.7 0.47 9.28e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg01657329 chr11:68192670 LRP5 -0.48 -7.59 -0.38 3.18e-13 Total body bone mineral density; LUSC trans rs11039798 1.000 rs7104642 chr11:48588534 C/T cg15704280 chr7:45808275 SEPT13 0.72 6.85 0.35 3.54e-11 Axial length; LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg11062466 chr8:58055876 NA 0.64 8.41 0.42 1.21e-15 Developmental language disorder (linguistic errors); LUSC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg25019033 chr10:957182 NA -0.52 -7.22 -0.37 3.55e-12 Eosinophil percentage of granulocytes; LUSC cis rs10504073 0.647 rs56057508 chr8:49982793 G/T cg00325661 chr8:49890786 NA 0.63 10.09 0.48 4.51e-21 Blood metabolite ratios; LUSC cis rs7267979 0.844 rs6083824 chr20:25363057 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -16.94 -0.68 6.65e-47 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg02018176 chr4:1364513 KIAA1530 0.57 10.3 0.49 8.48e-22 Longevity; LUSC cis rs7246967 0.611 rs62120457 chr19:22958519 A/G cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.41 -0.38 1.03e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg15744005 chr10:104629667 AS3MT -0.28 -5.92 -0.31 7.82e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg14847009 chr1:175162515 KIAA0040 -0.31 -5.96 -0.31 6.47e-9 Diastolic blood pressure; LUSC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg05863683 chr7:1912471 MAD1L1 0.31 5.96 0.31 6.31e-9 Bipolar disorder and schizophrenia; LUSC cis rs7903847 0.642 rs11189192 chr10:99149403 G/A cg20016023 chr10:99160130 RRP12 -0.32 -7.77 -0.39 1.01e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg08270630 chr22:50330655 NA -0.43 -6.43 -0.33 4.35e-10 Schizophrenia; LUSC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg00784671 chr22:46762841 CELSR1 -0.49 -6.7 -0.34 8.75e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg23161317 chr6:28129485 ZNF389 0.44 5.67 0.3 3.05e-8 Parkinson's disease; LUSC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg14552801 chr7:65878734 NA 0.38 5.93 0.31 7.76e-9 Aortic root size; LUSC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg13683864 chr3:40499215 RPL14 -0.97 -16.36 -0.67 1.39e-44 Renal cell carcinoma; LUSC trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs75804782 0.641 rs72987327 chr2:239359833 T/G cg01134436 chr17:81009848 B3GNTL1 0.66 6.41 0.33 4.82e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 12.04 0.55 5.76e-28 Chronic sinus infection; LUSC trans rs7939886 0.920 rs80232778 chr11:55970655 G/A cg15704280 chr7:45808275 SEPT13 0.9 6.87 0.35 3.14e-11 Myopia (pathological); LUSC cis rs3862435 0.518 rs2601166 chr15:90911179 G/A cg22089800 chr15:90895588 ZNF774 0.58 6.35 0.33 6.93e-10 Response to exercise (triglyceride level interaction); LUSC cis rs7826238 0.524 rs2921055 chr8:8319342 C/A cg06636001 chr8:8085503 FLJ10661 0.67 10.88 0.51 8.14e-24 Systolic blood pressure; LUSC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.28 -0.53 3.08e-25 Schizophrenia; LUSC cis rs56804039 1.000 rs67180327 chr8:8380754 G/A cg15556689 chr8:8085844 FLJ10661 -0.56 -6.96 -0.36 1.84e-11 Cervical cancer; LUSC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg25072359 chr17:41440525 NA 0.66 9.27 0.45 2.4e-18 Menopause (age at onset); LUSC trans rs9650657 0.655 rs1991651 chr8:10706411 C/G cg15556689 chr8:8085844 FLJ10661 0.43 6.39 0.33 5.61e-10 Neuroticism; LUSC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.33 0.41 2.18e-15 Height; LUSC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 8.4 0.42 1.29e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg09034736 chr1:150693464 HORMAD1 0.5 7.17 0.37 4.82e-12 Tonsillectomy; LUSC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC cis rs1451375 0.657 rs12665904 chr7:50635399 A/G cg18232548 chr7:50535776 DDC 0.51 7.79 0.39 8.37e-14 Malaria; LUSC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg13175981 chr1:150552382 MCL1 -0.41 -5.65 -0.3 3.53e-8 Melanoma; LUSC cis rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05901451 chr6:126070800 HEY2 -0.58 -8.78 -0.43 8.6e-17 Endometrial cancer; LUSC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg15704280 chr7:45808275 SEPT13 -0.86 -14.77 -0.63 2.42e-38 Height; LUSC cis rs17092148 1.000 rs3787220 chr20:33337751 T/C cg16810054 chr20:33298113 TP53INP2 -0.41 -6.42 -0.33 4.77e-10 Neuroticism; LUSC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg18904891 chr8:8559673 CLDN23 0.61 8.43 0.42 1.05e-15 Obesity-related traits; LUSC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg00677455 chr12:58241039 CTDSP2 0.63 8.89 0.44 3.99e-17 Multiple sclerosis; LUSC trans rs11700980 0.551 rs2832013 chr21:30110940 C/T cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.41e-9 QRS complex (12-leadsum); LUSC cis rs735539 0.645 rs9552253 chr13:21202350 T/C cg04906043 chr13:21280425 IL17D -0.41 -6.53 -0.34 2.5e-10 Dental caries; LUSC cis rs2898681 0.561 rs2200225 chr4:53738411 A/G cg21521518 chr4:53727714 RASL11B 0.41 5.81 0.3 1.43e-8 Optic nerve measurement (cup area); LUSC trans rs11722228 0.522 rs12503195 chr4:10082772 T/C cg26043149 chr18:55253948 FECH 0.71 11.26 0.52 3.82e-25 Gout;Urate levels;Serum uric acid levels; LUSC cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.51 0.38 5.59e-13 Motion sickness; LUSC cis rs7681440 0.874 rs1442154 chr4:90775761 C/G cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.31 1.15e-8 Dementia with Lewy bodies; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6424115 1.000 rs58035855 chr1:24165248 G/C cg10978503 chr1:24200527 CNR2 -0.51 -11.65 -0.54 1.44e-26 Immature fraction of reticulocytes; LUSC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg15448220 chr1:150897856 SETDB1 0.42 6.11 0.32 2.8e-9 Melanoma; LUSC cis rs34779708 0.966 rs12775799 chr10:35488264 C/T cg04310649 chr10:35416472 CREM -0.4 -6.24 -0.32 1.35e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7215564 0.908 rs35821645 chr17:78652479 G/A cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs9811920 0.598 rs793470 chr3:99548274 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.41 -0.42 1.17e-15 Axial length; LUSC cis rs1461503 0.900 rs10892935 chr11:122838590 C/T cg27398637 chr11:122830231 C11orf63 -0.4 -6.37 -0.33 6.12e-10 Menarche (age at onset); LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9549260 0.609 rs9315780 chr13:41263960 C/T cg21288729 chr13:41239152 FOXO1 0.56 8.31 0.41 2.36e-15 Red blood cell count; LUSC cis rs1775715 0.707 rs2808088 chr10:32146150 A/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.9 0.4 3.96e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs72772090 0.539 rs72773932 chr5:96118148 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.58 -0.34 1.83e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1595825 1.000 rs73058834 chr2:198873779 T/G cg19156104 chr2:198669113 PLCL1 -0.46 -5.68 -0.3 2.91e-8 Ulcerative colitis; LUSC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg26769984 chr7:1090371 C7orf50 0.72 10.41 0.49 3.66e-22 Bronchopulmonary dysplasia; LUSC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg13560548 chr3:10150139 C3orf24 0.53 7.43 0.38 9.1e-13 Alzheimer's disease; LUSC cis rs7264396 0.690 rs2425170 chr20:34442672 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.58 -0.42 3.7e-16 Total cholesterol levels; LUSC cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg23711669 chr6:146136114 FBXO30 -0.89 -16.71 -0.67 5.59e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg24060327 chr5:131705240 SLC22A5 -0.66 -11.6 -0.54 2.26e-26 Breast cancer; LUSC cis rs7223966 0.921 rs3020612 chr17:61960878 C/T cg11494091 chr17:61959527 GH2 0.38 6.24 0.32 1.31e-9 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs7824557 0.545 rs2736303 chr8:11236850 C/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.5 -0.34 2.9e-10 Retinal vascular caliber; LUSC cis rs11785400 0.701 rs9297967 chr8:143723002 A/C cg24634471 chr8:143751801 JRK 0.51 7.16 0.36 5.14e-12 Schizophrenia; LUSC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg11317459 chr13:21872234 NA 1.25 19.52 0.73 3.81e-57 White matter hyperintensity burden; LUSC cis rs6060717 0.536 rs7271036 chr20:34467215 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.55 5.67 0.3 3.14e-8 Hip circumference adjusted for BMI; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24538372 chr2:105953882 C2orf49 -0.52 -6.74 -0.35 6.82e-11 Hepatitis; LUSC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg01017244 chr2:74357527 NA 0.67 11.04 0.52 2.21e-24 Gestational age at birth (maternal effect); LUSC cis rs8141529 0.956 rs132539 chr22:29304253 C/T cg15103426 chr22:29168792 CCDC117 0.45 5.8 0.3 1.52e-8 Lymphocyte counts; LUSC cis rs911119 0.913 rs3004139 chr20:23578674 C/T cg16589663 chr20:23618590 CST3 -0.56 -6.67 -0.34 1.08e-10 Chronic kidney disease; LUSC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg10755058 chr3:40428713 ENTPD3 0.38 6.29 0.33 1e-9 Renal cell carcinoma; LUSC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs2294693 0.530 rs9381034 chr6:41049508 T/C cg14769373 chr6:40998127 UNC5CL -0.46 -5.81 -0.3 1.49e-8 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg05025164 chr4:1340916 KIAA1530 0.41 6.12 0.32 2.59e-9 Obesity-related traits; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg08088566 chr11:430123 ANO9 0.66 7.18 0.37 4.57e-12 Body mass index; LUSC cis rs12216125 0.549 rs9358905 chr6:26077839 T/A cg16482183 chr6:26056742 HIST1H1C 0.56 8.49 0.42 6.98e-16 Iron status biomarkers; LUSC cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.47e-12 Motion sickness; LUSC trans rs1814175 0.645 rs1818895 chr11:50031523 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.62 -0.73 1.47e-57 Height; LUSC cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg01579765 chr21:45077557 HSF2BP -0.5 -10.55 -0.5 1.15e-22 Mean corpuscular volume; LUSC cis rs1034435 0.962 rs1894542 chr22:48890335 G/C cg05992904 chr22:48892994 FAM19A5 -0.38 -7.4 -0.38 1.14e-12 Late-onset Alzheimer's disease; LUSC cis rs637571 0.522 rs491973 chr11:65727301 A/G cg26695010 chr11:65641043 EFEMP2 -0.48 -7.23 -0.37 3.32e-12 Eosinophil percentage of white cells; LUSC cis rs4423214 1.000 rs12790010 chr11:71170653 T/C cg05163923 chr11:71159392 DHCR7 0.74 11.07 0.52 1.79e-24 Vitamin D levels; LUSC cis rs2281558 0.583 rs11087526 chr20:25648016 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.53 6.34 0.33 7.33e-10 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs3770081 0.826 rs1019591 chr2:86298599 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.85 -6.07 -0.32 3.48e-9 Facial emotion recognition (sad faces); LUSC cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg16339924 chr4:17578868 LAP3 0.59 9.1 0.45 8.66e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4363385 0.747 rs1984198 chr1:152958584 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.78 -0.39 9.33e-14 Inflammatory skin disease; LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 16.09 0.66 1.53e-43 Platelet count; LUSC cis rs9660992 0.736 rs72745207 chr1:205251991 C/G cg21643547 chr1:205240462 TMCC2 -0.51 -9.54 -0.46 3.08e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg04025307 chr7:1156635 C7orf50 0.55 8.92 0.44 3.22e-17 Longevity;Endometriosis; LUSC cis rs4776059 0.798 rs11855616 chr15:52874833 C/T cg25063058 chr15:52860530 ARPP19 -0.48 -5.95 -0.31 6.7e-9 Schizophrenia; LUSC cis rs4786125 0.587 rs9938245 chr16:6926744 T/G cg03623568 chr16:6915990 A2BP1 -0.5 -8.34 -0.42 1.94e-15 Heart rate variability traits (SDNN); LUSC cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg22906224 chr7:99728672 NA 0.55 8.13 0.41 8.36e-15 Coronary artery disease; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.94 -14.58 -0.62 1.34e-37 Alzheimer's disease; LUSC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg16447950 chr5:562315 NA -0.58 -7.11 -0.36 7.26e-12 Lung disease severity in cystic fibrosis; LUSC cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg06784218 chr1:46089804 CCDC17 0.53 10.22 0.49 1.67e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9303401 0.659 rs12946397 chr17:56769979 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC trans rs2039659 0.719 rs1764953 chr13:86253145 C/A cg22803222 chr6:76636725 IMPG1 0.37 5.99 0.31 5.56e-9 Blood osmolality (transformed sodium); LUSC cis rs7605827 0.930 rs7598196 chr2:15596662 A/G cg19274914 chr2:15703543 NA 0.46 8.69 0.43 1.62e-16 Educational attainment (years of education); LUSC cis rs72634258 0.945 rs12753070 chr1:8114319 C/G cg26816564 chr1:7831052 VAMP3 0.5 5.97 0.31 6.12e-9 Inflammatory bowel disease; LUSC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg03264133 chr6:25882463 NA 0.39 6.46 0.33 3.62e-10 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg19230755 chr7:65878503 NA -0.43 -6.02 -0.31 4.48e-9 Aortic root size; LUSC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg04871131 chr7:94954202 PON1 -0.39 -6.19 -0.32 1.72e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg11764359 chr7:65958608 NA -0.68 -10.47 -0.5 2.3e-22 Aortic root size; LUSC cis rs4803468 1.000 rs284655 chr19:41928765 C/T cg09537434 chr19:41945824 ATP5SL -0.92 -16.09 -0.66 1.58e-43 Height; LUSC cis rs9653442 0.545 rs2009095 chr2:100765081 C/T cg22139774 chr2:100720529 AFF3 -0.41 -7.06 -0.36 9.45e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg06484146 chr7:12443880 VWDE -0.73 -7.31 -0.37 1.98e-12 Coronary artery disease; LUSC trans rs1005277 0.563 rs2800550 chr10:38482929 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.16 -0.45 5.33e-18 Extrinsic epigenetic age acceleration; LUSC cis rs4478858 0.611 rs10914338 chr1:31733782 T/A cg00250761 chr1:31883323 NA -0.33 -8.06 -0.4 1.35e-14 Alcohol dependence; LUSC cis rs7131987 0.903 rs11050163 chr12:29420398 C/T cg09582351 chr12:29534625 ERGIC2 -0.31 -6.39 -0.33 5.44e-10 QT interval; LUSC trans rs800082 0.668 rs9821986 chr3:144292701 T/G cg24215973 chr2:240111563 HDAC4 -0.61 -9.81 -0.47 3.99e-20 Smoking behavior; LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.98 0.61 2.7e-35 Platelet count; LUSC cis rs9399135 0.967 rs4451151 chr6:135310546 C/T cg22676075 chr6:135203613 NA 0.47 7.4 0.38 1.08e-12 Red blood cell count; LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg24060327 chr5:131705240 SLC22A5 -0.67 -11.68 -0.54 1.15e-26 Breast cancer; LUSC trans rs9291683 0.530 rs4697698 chr4:9942577 C/T cg26043149 chr18:55253948 FECH 0.45 6.85 0.35 3.51e-11 Bone mineral density; LUSC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg20203395 chr5:56204925 C5orf35 -0.78 -10.2 -0.49 1.93e-21 Initial pursuit acceleration; LUSC cis rs79387448 0.745 rs2310294 chr2:103165706 A/G cg09003973 chr2:102972529 NA 0.89 8.62 0.43 2.69e-16 Gut microbiota (bacterial taxa); LUSC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg18512352 chr11:47633146 NA -0.48 -10.05 -0.48 6.4e-21 Subjective well-being; LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg10729496 chr3:10149963 C3orf24 0.56 7.62 0.38 2.62e-13 Alzheimer's disease; LUSC cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.01 0.36 1.33e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19074533 chr20:25604700 NANP -0.41 -6.02 -0.31 4.64e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs17092148 0.945 rs6060009 chr20:33303974 T/G cg16810054 chr20:33298113 TP53INP2 -0.39 -6.21 -0.32 1.53e-9 Neuroticism; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg01411255 chr17:61851458 DDX42;CCDC47 -0.54 -8.37 -0.42 1.56e-15 Prudent dietary pattern; LUSC cis rs4604732 0.631 rs12038793 chr1:247624262 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.47 -6.81 -0.35 4.64e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9303401 0.659 rs17822837 chr17:56737838 C/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.73 0.43 1.24e-16 Cognitive test performance; LUSC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.2 0.45 4.11e-18 Monocyte percentage of white cells; LUSC cis rs6964587 0.967 rs6465353 chr7:91779971 G/T cg17063962 chr7:91808500 NA -0.56 -9.27 -0.45 2.33e-18 Breast cancer; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg13665263 chr7:135662016 MTPN;LUZP6 0.38 6.39 0.33 5.65e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC trans rs62238980 0.614 rs17683310 chr22:32477445 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 0.51 6.04 0.31 4.04e-9 Childhood ear infection; LUSC cis rs42235 0.683 rs60814640 chr7:92286918 A/G cg15732164 chr7:92237376 CDK6 -0.37 -5.86 -0.31 1.12e-8 Hip circumference adjusted for BMI;Height; LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg01879757 chr17:41196368 BRCA1 -0.47 -7.09 -0.36 7.95e-12 Menopause (age at onset); LUSC cis rs12421382 0.576 rs116158609 chr11:109389358 T/A cg27471124 chr11:109292789 C11orf87 0.38 6.94 0.35 2.08e-11 Schizophrenia; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg27094323 chr7:1216898 NA -0.47 -8.4 -0.42 1.32e-15 Longevity;Endometriosis; LUSC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg00933542 chr6:150070202 PCMT1 0.33 6.76 0.35 6.34e-11 Lung cancer; LUSC cis rs4356932 1.000 rs4859600 chr4:76959967 C/G cg00809888 chr4:76862425 NAAA 0.35 5.8 0.3 1.53e-8 Blood protein levels; LUSC cis rs17001868 0.568 rs2280790 chr22:40745181 T/C cg07138101 chr22:40742427 ADSL 0.62 7.45 0.38 8.07e-13 Mammographic density (dense area); LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 13.71 0.6 2.98e-34 Platelet count; LUSC cis rs11997175 0.625 rs4733171 chr8:33615617 C/G ch.8.33884649F chr8:33765107 NA -0.4 -6.36 -0.33 6.65e-10 Body mass index; LUSC cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.51e-15 Axial length; LUSC cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg03146154 chr1:46216737 IPP 0.5 7.38 0.37 1.28e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1559088 0.803 rs10411529 chr19:33616256 A/C cg03563238 chr19:33554763 RHPN2 -0.37 -5.92 -0.31 7.79e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11190604 1.000 rs2495755 chr10:102324649 A/C cg16342193 chr10:102329863 NA -0.4 -6.51 -0.34 2.75e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg24642439 chr20:33292090 TP53INP2 0.5 7.5 0.38 5.77e-13 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs6430585 0.702 rs746857 chr2:136554890 G/A cg07169764 chr2:136633963 MCM6 -1.13 -16.48 -0.67 4.61e-45 Corneal structure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23311531 chr8:94712629 FAM92A1 -0.39 -6.08 -0.32 3.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs36096196 0.891 rs12081179 chr1:2251119 A/G cg17974515 chr1:2252516 NA 0.39 7.3 0.37 2.18e-12 Coronary artery disease; LUSC cis rs11025523 0.904 rs10833311 chr11:20379638 C/T cg19653624 chr11:20408972 PRMT3 -0.51 -5.95 -0.31 6.77e-9 Obesity-related traits; LUSC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg08219700 chr8:58056026 NA 0.47 6.26 0.32 1.21e-9 Developmental language disorder (linguistic errors); LUSC cis rs5758659 1.000 rs134882 chr22:42670965 A/G cg04733989 chr22:42467013 NAGA 0.4 6.49 0.33 3.19e-10 Cognitive function; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.36 0.53 1.63e-25 Prudent dietary pattern; LUSC cis rs8099014 1.000 rs4940698 chr18:56108914 G/A cg12907477 chr18:56117327 MIR122 0.44 7.02 0.36 1.28e-11 Platelet count; LUSC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.28 0.32 1.08e-9 Tonsillectomy; LUSC cis rs11785400 1.000 rs13266249 chr8:143732433 A/C cg10596483 chr8:143751796 JRK 0.62 9.29 0.45 2.06e-18 Schizophrenia; LUSC cis rs7408868 0.572 rs2074616 chr19:15294991 C/T cg14696996 chr19:15285081 NOTCH3 0.67 6.99 0.36 1.48e-11 Pulse pressure; LUSC cis rs3540 0.512 rs3930162 chr15:91075129 C/T cg22089800 chr15:90895588 ZNF774 -0.59 -9.06 -0.44 1.11e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18960028 chr11:75526075 UVRAG -0.49 -6.28 -0.32 1.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg21361702 chr7:150065534 REPIN1 0.5 6.84 0.35 3.79e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.17e-9 Blood metabolite levels; LUSC cis rs11583043 0.872 rs1326380 chr1:101293753 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 6.13 0.32 2.42e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7215564 0.908 rs7501544 chr17:78660946 T/A cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg12071656 chr20:44642570 MMP9 0.41 6.82 0.35 4.2e-11 Metabolite levels (Pyroglutamine); LUSC cis rs4820539 1.000 rs4822361 chr22:23482718 A/G cg21100191 chr22:23484243 RTDR1 -0.91 -15.99 -0.66 3.86e-43 Bone mineral density; LUSC cis rs34779708 0.733 rs4934740 chr10:35547141 C/T cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6500395 1.000 rs7197732 chr16:48575878 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.53 0.34 2.52e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs751728 1.000 rs747695 chr6:33736672 G/A cg25922239 chr6:33757077 LEMD2 0.55 8.1 0.41 1.02e-14 Crohn's disease; LUSC cis rs4474465 1.000 rs11237520 chr11:78201201 G/C cg27205649 chr11:78285834 NARS2 -0.52 -6.01 -0.31 4.99e-9 Alzheimer's disease (survival time); LUSC cis rs701145 0.617 rs7426835 chr3:154049539 C/T cg17054900 chr3:154042577 DHX36 0.48 6.92 0.35 2.36e-11 Coronary artery disease; LUSC cis rs7582720 1.000 rs72932590 chr2:203884308 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.64 0.43 2.32e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs72781680 0.752 rs72796138 chr2:23926233 C/T cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.4e-12 Lymphocyte counts; LUSC cis rs7954584 0.813 rs1523261 chr12:122462877 C/A cg21171335 chr12:122356390 WDR66 0.42 5.89 0.31 9.23e-9 Mean corpuscular volume; LUSC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs79387448 0.745 rs17027496 chr2:103178223 T/A cg09003973 chr2:102972529 NA 0.87 8.35 0.42 1.8e-15 Gut microbiota (bacterial taxa); LUSC cis rs244731 0.959 rs6872021 chr5:176610012 G/A cg06060754 chr5:176797920 RGS14 -0.61 -8.88 -0.44 4.16e-17 Urate levels in lean individuals; LUSC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg06108461 chr20:60628389 TAF4 -0.95 -14.95 -0.63 4.79e-39 Body mass index; LUSC cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg02153584 chr22:29168773 CCDC117 0.55 7.61 0.38 2.9e-13 Lymphocyte counts; LUSC cis rs2637266 1.000 rs12414151 chr10:78359041 T/G cg18941641 chr10:78392320 NA 0.38 7.08 0.36 8.29e-12 Pulmonary function; LUSC cis rs2224391 0.590 rs2753235 chr6:5252182 C/T cg09085698 chr6:5261316 LYRM4;FARS2 0.49 7.0 0.36 1.42e-11 Height; LUSC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg05234568 chr11:5960015 NA -0.6 -8.64 -0.43 2.43e-16 DNA methylation (variation); LUSC cis rs12893668 0.645 rs35229468 chr14:104052057 C/T cg04998671 chr14:104000505 TRMT61A -0.46 -6.71 -0.34 8.55e-11 Reticulocyte count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13265914 chr8:21999630 REEP4 0.43 6.24 0.32 1.36e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.36 -7.52 -0.38 4.97e-13 Hemoglobin concentration; LUSC cis rs17685 0.753 rs6976532 chr7:75681094 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.75 -0.39 1.14e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs208520 0.526 rs2881644 chr6:66803535 A/C cg07460842 chr6:66804631 NA 1.23 26.78 0.83 3.63e-85 Exhaled nitric oxide output; LUSC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11890956 chr21:40555474 PSMG1 1.02 20.37 0.74 1.57e-60 Cognitive function; LUSC cis rs77633900 0.772 rs284901 chr15:76747761 C/T cg21673338 chr15:77095150 SCAPER -0.69 -5.68 -0.3 2.87e-8 Non-glioblastoma glioma;Glioma; LUSC trans rs1486139 1.000 rs7779727 chr7:46267566 G/A cg17534202 chr9:96721102 NA -0.35 -6.15 -0.32 2.26e-9 Select biomarker traits; LUSC cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -1.25 -33.12 -0.88 1.52e-107 Chronic sinus infection; LUSC cis rs9467773 0.935 rs9461270 chr6:26544110 A/G cg05738196 chr6:26577821 NA 0.81 15.88 0.66 1.04e-42 Intelligence (multi-trait analysis); LUSC cis rs2692947 0.832 rs62153679 chr2:96558400 C/T cg22654517 chr2:96458247 NA 0.38 7.58 0.38 3.45e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11190604 0.943 rs3750631 chr10:102279294 A/G cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1387259 0.929 rs2956703 chr12:48670294 C/T cg04545296 chr12:48745243 ZNF641 0.33 6.14 0.32 2.4e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs1395 0.925 rs1659676 chr2:27399294 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.41 -6.91 -0.35 2.45e-11 Blood metabolite levels; LUSC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg06634786 chr22:41940651 POLR3H -0.56 -6.56 -0.34 2.05e-10 Vitiligo; LUSC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1728785 0.681 rs4783649 chr16:68558467 G/A cg02972257 chr16:68554789 NA 0.58 7.15 0.36 5.59e-12 Ulcerative colitis; LUSC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg25258033 chr6:167368657 RNASET2 0.44 7.05 0.36 1.06e-11 Crohn's disease; LUSC cis rs939658 0.805 rs35318825 chr15:79447098 C/A cg17916960 chr15:79447300 NA -0.55 -11.07 -0.52 1.86e-24 Refractive error; LUSC cis rs12956009 0.583 rs12327454 chr18:44863964 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.34 0.33 7.55e-10 Educational attainment (years of education); LUSC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.2 0.64 5.07e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9393777 0.920 rs34150729 chr6:27388754 T/C cg06606381 chr12:133084897 FBRSL1 -1.02 -9.12 -0.45 7.21e-18 Intelligence (multi-trait analysis); LUSC cis rs6908843 0.582 rs7758118 chr6:166663862 T/G cg06878426 chr6:166666287 NA 0.46 6.3 0.33 9.19e-10 Macrophage inflammatory protein 1b levels; LUSC cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg04450456 chr4:17643702 FAM184B 0.36 6.02 0.31 4.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7953508 0.506 rs2200160 chr12:93963873 C/T cg18151635 chr12:93972918 NA -0.61 -8.83 -0.44 5.91e-17 Pubertal anthropometrics; LUSC trans rs61931739 0.817 rs2636084 chr12:34130210 G/A cg13010199 chr12:38710504 ALG10B 0.44 6.95 0.36 1.93e-11 Morning vs. evening chronotype; LUSC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg25072359 chr17:41440525 NA 0.62 9.05 0.44 1.2e-17 Menopause (age at onset); LUSC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg17294928 chr15:75287854 SCAMP5 -0.92 -12.84 -0.57 5.9e-31 Blood trace element (Zn levels); LUSC cis rs243505 1.000 rs243505 chr7:148435339 A/G cg09806900 chr7:148480153 CUL1 -0.47 -6.73 -0.35 7.44e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg18200150 chr17:30822561 MYO1D 0.52 10.65 0.5 5.37e-23 Schizophrenia; LUSC cis rs9325144 0.647 rs11169189 chr12:39097078 A/T cg26384229 chr12:38710491 ALG10B -0.57 -8.65 -0.43 2.13e-16 Morning vs. evening chronotype; LUSC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg27129171 chr3:47204927 SETD2 0.73 12.61 0.57 4.3e-30 Colorectal cancer; LUSC cis rs7937682 0.961 rs7119563 chr11:111543916 T/A cg09085632 chr11:111637200 PPP2R1B 1.06 15.63 0.65 1.06e-41 Primary sclerosing cholangitis; LUSC cis rs6681460 0.932 rs523956 chr1:67188276 A/G cg02459107 chr1:67143332 SGIP1 -0.45 -8.19 -0.41 5.5e-15 Presence of antiphospholipid antibodies; LUSC cis rs10769945 0.679 rs2137322 chr11:1917354 A/G cg26856596 chr11:1961893 NA -0.32 -6.36 -0.33 6.73e-10 DNA methylation (variation); LUSC cis rs9527 0.590 rs10786741 chr10:104939182 G/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.39 -0.33 5.57e-10 Arsenic metabolism; LUSC cis rs9649465 0.561 rs2429620 chr7:123430012 A/G cg03229431 chr7:123269106 ASB15 0.48 7.71 0.39 1.49e-13 Migraine; LUSC cis rs7200543 1.000 rs4500751 chr16:15140211 C/T cg03427771 chr16:15082598 PDXDC1 -0.4 -5.7 -0.3 2.61e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07220488 chr17:77006061 CANT1 -0.52 -6.04 -0.31 4.03e-9 Bipolar disorder and schizophrenia; LUSC cis rs3126085 0.735 rs4845752 chr1:152226576 C/A cg26876637 chr1:152193138 HRNR 0.44 6.21 0.32 1.62e-9 Atopic dermatitis; LUSC trans rs561341 1.000 rs508192 chr17:30315147 C/T cg20587970 chr11:113659929 NA 1.23 16.53 0.67 2.82e-45 Hip circumference adjusted for BMI; LUSC cis rs17095355 1.000 rs55897175 chr10:111699190 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.6 -0.38 2.95e-13 Biliary atresia; LUSC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg18876405 chr7:65276391 NA -0.7 -12.3 -0.56 5.96e-29 Aortic root size; LUSC trans rs4689388 0.890 rs4689397 chr4:6299387 G/A cg17567195 chr5:167378696 ODZ2 -0.39 -6.01 -0.31 4.78e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.48 -6.44 -0.33 4.27e-10 Tonsillectomy; LUSC cis rs62400317 0.859 rs12201555 chr6:45294400 T/A cg20913747 chr6:44695427 NA -0.47 -7.62 -0.38 2.63e-13 Total body bone mineral density; LUSC cis rs796364 0.806 rs112486506 chr2:201073947 C/T cg23649088 chr2:200775458 C2orf69 -0.57 -6.74 -0.35 7.11e-11 Schizophrenia; LUSC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 7.82 0.39 7.19e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg05347473 chr6:146136440 FBXO30 0.49 8.24 0.41 3.93e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs713477 0.712 rs72717779 chr14:55893440 A/G cg04306507 chr14:55594613 LGALS3 -0.32 -6.45 -0.33 3.85e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.31 -6.49 -0.33 3.09e-10 Cystic fibrosis severity; LUSC cis rs10751667 0.961 rs7943115 chr11:973885 T/C ch.11.42038R chr11:967971 AP2A2 0.54 8.23 0.41 4.38e-15 Alzheimer's disease (late onset); LUSC cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg03934865 chr2:198174659 NA 0.35 5.87 0.31 1.07e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs12579753 0.917 rs11115032 chr12:82205073 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs9467711 0.606 rs9358930 chr6:26357011 C/T cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg12560992 chr17:57184187 TRIM37 0.88 16.86 0.68 1.41e-46 Intelligence (multi-trait analysis); LUSC cis rs9921338 0.961 rs7626 chr16:11445596 C/T cg00044050 chr16:11439710 C16orf75 -0.51 -6.7 -0.34 9e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs9640161 0.830 rs1051764 chr7:150070663 T/C cg27494647 chr7:150038898 RARRES2 0.36 5.8 0.3 1.55e-8 Blood protein levels;Circulating chemerin levels; LUSC trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg15704280 chr7:45808275 SEPT13 -0.96 -13.89 -0.61 6.19e-35 Coronary artery disease; LUSC cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg23173402 chr1:227635558 NA 0.58 7.0 0.36 1.45e-11 Major depressive disorder; LUSC cis rs72781680 0.716 rs2712061 chr2:24026411 G/A cg08917208 chr2:24149416 ATAD2B 0.62 7.13 0.36 6.07e-12 Lymphocyte counts; LUSC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg02018176 chr4:1364513 KIAA1530 0.47 8.01 0.4 1.93e-14 Obesity-related traits; LUSC cis rs887829 0.569 rs4399719 chr2:234666461 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.53 -0.38 4.68e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.66 -0.34 1.13e-10 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs17286411 0.669 rs4788809 chr16:71615820 G/A cg10085824 chr16:71800315 AP1G1 0.35 5.66 0.3 3.24e-8 Blood protein levels; LUSC cis rs950169 0.881 rs34117475 chr15:85108443 T/C cg17507749 chr15:85114479 UBE2QP1 0.72 9.39 0.46 9.61e-19 Schizophrenia; LUSC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3947 1.000 rs2645425 chr8:11701278 G/A cg00262122 chr8:11665843 FDFT1 -0.51 -6.13 -0.32 2.45e-9 Blood protein levels; LUSC cis rs2742234 0.541 rs11238481 chr10:43719286 A/G cg02780029 chr10:43622663 RET 0.35 5.82 0.3 1.41e-8 Hirschsprung disease; LUSC cis rs9303401 0.703 rs8072182 chr17:57211213 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.52 8.03 0.4 1.73e-14 Cognitive test performance; LUSC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg10645314 chr2:3704589 ALLC -0.48 -7.18 -0.37 4.44e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs17401966 0.838 rs34565762 chr1:10300119 T/C cg19773385 chr1:10388646 KIF1B -0.52 -8.98 -0.44 2.08e-17 Hepatocellular carcinoma; LUSC cis rs8099014 1.000 rs7238962 chr18:56130112 A/G cg12907477 chr18:56117327 MIR122 0.44 7.04 0.36 1.11e-11 Platelet count; LUSC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg18876405 chr7:65276391 NA -0.54 -8.49 -0.42 7.05e-16 Aortic root size; LUSC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.66e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2730245 1.000 rs2657345 chr7:158744169 T/C cg14689365 chr7:158441557 NCAPG2 -0.47 -6.33 -0.33 8.12e-10 Height; LUSC trans rs11696501 0.637 rs3746596 chr20:44312028 C/T cg03272292 chr12:48577362 C12orf68 0.53 6.33 0.33 7.83e-10 Brain structure; LUSC cis rs2832077 1.000 rs2832065 chr21:30135362 C/T cg24692254 chr21:30365293 RNF160 -0.56 -6.86 -0.35 3.34e-11 Cognitive test performance; LUSC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4925386 0.921 rs11204472 chr20:60920887 G/A cg22601191 chr20:60968625 CABLES2 -0.37 -6.03 -0.31 4.33e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs10511400 0.850 rs9289142 chr3:119892779 G/T cg02809009 chr19:50354510 PTOV1 0.64 5.99 0.31 5.37e-9 Economic and political preferences (feminism/equality); LUSC cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.48 7.64 0.39 2.35e-13 IgG glycosylation; LUSC trans rs1376359 0.537 rs486226 chr1:103269537 G/A cg17154563 chr19:40477487 PSMC4 0.48 6.1 0.32 2.97e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg03060546 chr3:49711283 APEH 0.66 7.6 0.38 3.07e-13 Menarche (age at onset); LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg24881330 chr22:46731750 TRMU 0.88 8.87 0.44 4.55e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs7605827 0.930 rs2052438 chr2:15701951 G/A cg19274914 chr2:15703543 NA 0.46 8.64 0.43 2.43e-16 Educational attainment (years of education); LUSC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg17264618 chr3:40429014 ENTPD3 0.33 6.98 0.36 1.64e-11 Renal cell carcinoma; LUSC trans rs6601327 0.700 rs12114661 chr8:9573154 G/A cg15556689 chr8:8085844 FLJ10661 -0.44 -6.29 -0.33 1e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg27121462 chr16:89883253 FANCA -0.54 -8.74 -0.43 1.18e-16 Vitiligo; LUSC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg17366294 chr4:99064904 C4orf37 0.6 10.55 0.5 1.19e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs2204008 0.570 rs12318341 chr12:38251087 T/C cg26384229 chr12:38710491 ALG10B -0.57 -8.6 -0.43 3.1e-16 Bladder cancer; LUSC cis rs6998277 1.000 rs62523306 chr8:103640752 C/A cg10187029 chr8:103597600 NA 0.69 8.81 0.43 6.86e-17 Migraine; LUSC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg18904891 chr8:8559673 CLDN23 -0.43 -6.46 -0.33 3.63e-10 Mood instability; LUSC cis rs977987 0.778 rs12930452 chr16:75462055 A/G cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs7336332 0.598 rs9581852 chr13:28013748 A/G cg22138327 chr13:27999177 GTF3A 0.82 9.91 0.48 1.83e-20 Weight; LUSC trans rs71435601 0.628 rs504091 chr2:21403481 T/G cg20757404 chr19:378427 NA 0.38 6.02 0.31 4.71e-9 Cholesterol, total; LUSC cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg08085267 chr17:45401833 C17orf57 -0.55 -8.32 -0.41 2.24e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7424096 0.613 rs17332671 chr2:37244124 C/G cg14987922 chr2:37194071 STRN 0.61 8.2 0.41 5.41e-15 High light scatter reticulocyte percentage of red cells; LUSC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg09655341 chr17:79618100 PDE6G -0.27 -6.1 -0.32 3e-9 Eye color traits; LUSC cis rs9660992 0.700 rs1172125 chr1:205258442 A/T cg21643547 chr1:205240462 TMCC2 -0.49 -9.54 -0.46 3.16e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg11752832 chr7:134001865 SLC35B4 0.49 7.32 0.37 1.84e-12 Mean platelet volume; LUSC cis rs9814567 1.000 rs7429866 chr3:134236306 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.59 0.6 8.62e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -9.13 -0.45 6.82e-18 Developmental language disorder (linguistic errors); LUSC trans rs2898290 0.593 rs1600252 chr8:11345644 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.37 -0.42 1.6e-15 Systolic blood pressure; LUSC cis rs7789940 0.904 rs7459185 chr7:75934640 C/G cg10167463 chr7:75959203 YWHAG 0.58 8.58 0.42 3.66e-16 Multiple sclerosis; LUSC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg03233332 chr7:66118400 NA -0.43 -6.15 -0.32 2.22e-9 Aortic root size; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg07507251 chr3:52567010 NT5DC2 0.35 6.8 0.35 4.82e-11 Bipolar disorder; LUSC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg11366901 chr6:160182831 ACAT2 0.91 12.24 0.56 1.04e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs9815354 0.812 rs73077373 chr3:41852887 C/T cg03022575 chr3:42003672 ULK4 0.85 8.74 0.43 1.19e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1559088 1.000 rs8106453 chr19:33557412 C/T cg27124370 chr19:33622961 WDR88 0.52 6.65 0.34 1.22e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg06026331 chr20:60912101 LAMA5 0.64 7.73 0.39 1.24e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs11039798 0.588 rs10437592 chr11:48598859 G/T cg15704280 chr7:45808275 SEPT13 0.67 7.35 0.37 1.51e-12 Axial length; LUSC cis rs6754311 0.550 rs10173394 chr2:136522675 C/T cg25344623 chr2:136566232 LCT 0.37 5.69 0.3 2.84e-8 Mosquito bite size; LUSC cis rs7100689 0.784 rs7081903 chr10:82162509 T/C cg00277334 chr10:82204260 NA -0.54 -7.3 -0.37 2.12e-12 Post bronchodilator FEV1; LUSC cis rs253664 1.000 rs1720825 chr3:138108083 A/G cg25188949 chr3:137893707 DBR1 -0.49 -5.88 -0.31 9.73e-9 Body mass index; LUSC cis rs7000551 0.715 rs34649162 chr8:22314730 T/C cg12081754 chr8:22256438 SLC39A14 0.47 7.03 0.36 1.15e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7804356 0.906 rs10266759 chr7:26855282 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg26338869 chr17:61819248 STRADA 0.41 5.89 0.31 9.19e-9 Prudent dietary pattern; LUSC cis rs12122100 0.545 rs1984615 chr1:146506206 G/A cg03526459 chr1:146549940 NA -0.4 -7.15 -0.36 5.35e-12 HIV-1 control; LUSC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19717773 chr7:2847554 GNA12 -0.38 -6.24 -0.32 1.31e-9 Height; LUSC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.76 0.65 3.06e-42 Platelet count; LUSC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg04450456 chr4:17643702 FAM184B 0.39 6.77 0.35 5.88e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs34421088 0.560 rs2248325 chr8:11396874 A/G cg21775007 chr8:11205619 TDH -0.53 -7.96 -0.4 2.72e-14 Neuroticism; LUSC cis rs9549367 0.789 rs2287253 chr13:113891075 G/A cg00898013 chr13:113819073 PROZ 0.51 7.46 0.38 7.56e-13 Platelet distribution width; LUSC cis rs10740039 0.729 rs7091383 chr10:62436177 C/T cg18175470 chr10:62150864 ANK3 -0.45 -6.73 -0.35 7.58e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11608355 0.545 rs12823587 chr12:109896390 A/G cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs3750965 0.920 rs10896420 chr11:68863047 G/A cg06818126 chr11:68850279 TPCN2 -0.43 -6.37 -0.33 6.24e-10 Hair color; LUSC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC cis rs11864453 0.647 rs10492814 chr16:72126514 G/A cg16558253 chr16:72132732 DHX38 -0.37 -5.76 -0.3 1.86e-8 Fibrinogen levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03043160 chr13:76056444 TBC1D4 -0.58 -8.13 -0.41 8.43e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs981844 1.000 rs17299041 chr4:154673127 T/C cg14289246 chr4:154710475 SFRP2 0.51 6.57 0.34 1.98e-10 Response to statins (LDL cholesterol change); LUSC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg13770153 chr20:60521292 NA -0.64 -8.89 -0.44 3.86e-17 Body mass index; LUSC cis rs34891900 0.507 rs5992088 chr22:18135912 C/T cg19898043 chr22:18121309 BCL2L13 -0.36 -5.64 -0.3 3.55e-8 Sum neutrophil eosinophil counts; LUSC cis rs7552167 0.925 rs78312791 chr1:24513613 C/A cg01960748 chr1:24522592 NA 0.68 10.21 0.49 1.8e-21 Psoriasis vulgaris; LUSC cis rs6060987 1 rs6060987 chr20:30427077 T/A cg21427119 chr20:30132790 HM13 -0.36 -5.67 -0.3 3.14e-8 Mean corpuscular volume; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.54 9.14 0.45 6.21e-18 Prudent dietary pattern; LUSC cis rs17270561 0.609 rs3778272 chr6:25767661 G/A cg16482183 chr6:26056742 HIST1H1C 0.58 7.95 0.4 2.87e-14 Iron status biomarkers; LUSC cis rs4683142 0.518 rs4682811 chr3:46164795 A/G cg08033130 chr3:45983597 CXCR6;FYCO1 0.39 5.69 0.3 2.75e-8 Methadone dose in opioid dependence; LUSC cis rs6545883 0.525 rs1177274 chr2:61368532 T/G cg15711740 chr2:61764176 XPO1 -0.4 -6.29 -0.33 9.74e-10 Tuberculosis; LUSC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs9747201 1.000 rs55638685 chr17:80107566 G/C cg18209359 chr17:80159595 CCDC57 0.39 6.44 0.33 4.06e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs68170813 0.559 rs76859341 chr7:107070146 C/G cg02696742 chr7:106810147 HBP1 -0.61 -8.85 -0.44 5.36e-17 Coronary artery disease; LUSC trans rs12310956 0.515 rs1405031 chr12:33958931 A/C cg26384229 chr12:38710491 ALG10B 0.66 10.26 0.49 1.19e-21 Morning vs. evening chronotype; LUSC cis rs9811920 0.535 rs792831 chr3:99473720 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.31 -6.0 -0.31 5.01e-9 Axial length; LUSC cis rs7043114 0.507 rs2007837 chr9:95189767 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.9 -0.35 2.67e-11 Height; LUSC cis rs4969178 0.965 rs8071889 chr17:76398101 A/G cg05887092 chr17:76393375 PGS1 0.55 9.8 0.47 4.39e-20 HDL cholesterol levels; LUSC cis rs11676348 0.838 rs17844697 chr2:218999255 G/A cg00012203 chr2:219082015 ARPC2 -0.54 -8.24 -0.41 3.88e-15 Ulcerative colitis; LUSC cis rs7709377 0.574 rs11241372 chr5:115502656 T/C cg23108291 chr5:115420582 COMMD10 0.42 5.97 0.31 5.96e-9 Metabolite levels (X-11787); LUSC trans rs72674100 1.000 rs6830465 chr4:97977822 C/T cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg07716408 chr11:68623521 NA -0.35 -6.75 -0.35 6.38e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1395 0.778 rs724311 chr2:27441645 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.36 0.37 1.47e-12 Blood metabolite levels; LUSC cis rs637571 0.565 rs570387 chr11:65637076 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.48 -6.4 -0.33 5.27e-10 Eosinophil percentage of white cells; LUSC cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg00071950 chr4:10020882 SLC2A9 -0.58 -9.43 -0.46 7.32e-19 Bone mineral density; LUSC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg23758822 chr17:41437982 NA -1.01 -20.01 -0.74 4.1e-59 Menopause (age at onset); LUSC trans rs7980799 0.649 rs11559754 chr12:33649229 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.95 -0.31 6.71e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs7824557 0.836 rs765731 chr8:11121498 T/A cg27411982 chr8:10470053 RP1L1 -0.38 -5.99 -0.31 5.55e-9 Retinal vascular caliber; LUSC cis rs9653442 0.564 rs10197987 chr2:100790783 A/T cg22139774 chr2:100720529 AFF3 -0.4 -6.91 -0.35 2.54e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6430585 0.528 rs2278682 chr2:136743143 G/C cg07169764 chr2:136633963 MCM6 1.03 15.73 0.65 4.08e-42 Corneal structure; LUSC cis rs11958404 0.860 rs6868830 chr5:157442187 T/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs9649465 0.542 rs616297 chr7:123426949 A/G cg03229431 chr7:123269106 ASB15 0.48 7.81 0.39 7.37e-14 Migraine; LUSC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.61 8.56 0.42 4.1e-16 Schizophrenia; LUSC cis rs2290416 0.892 rs76225457 chr8:144666052 G/T cg26536354 chr8:144654954 C8orf73 0.65 7.1 0.36 7.37e-12 Attention deficit hyperactivity disorder; LUSC cis rs6005807 0.719 rs7293232 chr22:29015590 T/G cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs1559088 0.847 rs7254758 chr19:33608047 T/A cg27124370 chr19:33622961 WDR88 0.56 7.21 0.37 3.86e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg00343127 chr12:129299088 SLC15A4;MGC16384 0.35 5.68 0.3 2.99e-8 Systemic lupus erythematosus; LUSC trans rs2727020 0.615 rs35423199 chr11:49514914 T/C cg15704280 chr7:45808275 SEPT13 -1.1 -22.22 -0.77 8.57e-68 Coronary artery disease; LUSC cis rs4919687 0.550 rs11191371 chr10:104459897 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.68 -0.3 2.87e-8 Colorectal cancer; LUSC trans rs2980439 0.525 rs2980508 chr8:8171732 C/T cg19641455 chr1:111506798 C1orf103 0.4 5.95 0.31 6.68e-9 Neuroticism; LUSC cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg00530320 chr1:46809349 NSUN4 0.56 8.64 0.43 2.38e-16 Menopause (age at onset); LUSC trans rs12579753 1.000 rs11115047 chr12:82232773 C/G cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs10876993 0.893 rs7979246 chr12:58092554 A/G cg15848620 chr12:58087721 OS9 -0.57 -7.99 -0.4 2.17e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs10504073 0.647 rs62507247 chr8:50013554 T/G cg00325661 chr8:49890786 NA 0.62 9.97 0.48 1.13e-20 Blood metabolite ratios; LUSC cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg05347473 chr6:146136440 FBXO30 -0.48 -7.98 -0.4 2.39e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg25039879 chr17:56429692 SUPT4H1 0.74 10.28 0.49 1.03e-21 Cognitive test performance; LUSC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg17971929 chr21:40555470 PSMG1 0.51 7.91 0.4 3.85e-14 Cognitive function; LUSC cis rs9393777 0.841 rs13191474 chr6:27413345 C/T cg09904177 chr6:26538194 HMGN4 -0.77 -5.97 -0.31 6.22e-9 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg18479299 chr3:125709523 NA -0.5 -5.79 -0.3 1.66e-8 Blood pressure (smoking interaction); LUSC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg26380479 chr7:97908229 NA -0.27 -5.77 -0.3 1.8e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs790123 1.000 rs810976 chr3:122381683 T/C cg17380795 chr3:122379686 NA 0.39 6.59 0.34 1.7e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs735860 0.572 rs186003 chr6:53185124 A/C cg10236188 chr6:53219634 NA 0.4 6.31 0.33 8.75e-10 Glaucoma; LUSC cis rs11166629 1.000 rs1867059 chr8:135647019 A/G cg27224718 chr8:135614730 ZFAT 0.62 10.25 0.49 1.28e-21 Smoking quantity; LUSC cis rs1044826 1.000 rs9812192 chr3:139177597 C/T cg00490450 chr3:139108681 COPB2 0.5 6.61 0.34 1.5e-10 Obesity-related traits; LUSC cis rs2580764 0.515 rs7570629 chr2:55255935 A/T cg20993754 chr2:55226987 RTN4 0.35 5.86 0.31 1.13e-8 Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13170934 chr1:156722147 HDGF 0.41 6.21 0.32 1.62e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg24692254 chr21:30365293 RNF160 -0.83 -15.28 -0.64 2.37e-40 Dental caries; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg06145435 chr7:1022769 CYP2W1 0.3 6.22 0.32 1.5e-9 Longevity;Endometriosis; LUSC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg19592336 chr6:28129416 ZNF389 0.5 6.82 0.35 4.41e-11 Parkinson's disease; LUSC cis rs9902453 0.904 rs9894893 chr17:28270350 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.79 0.51 1.7e-23 Coffee consumption (cups per day); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20095036 chr4:153456176 FBXW7 0.36 5.99 0.31 5.28e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7681440 0.904 rs1822217 chr4:90765052 C/T cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs61990749 0.597 rs2267758 chr14:78147429 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.6 -6.43 -0.33 4.5e-10 Fibroblast growth factor basic levels; LUSC cis rs79911532 0.515 rs78085898 chr7:75703215 T/C cg03592824 chr7:75666768 STYXL1 0.67 6.42 0.33 4.79e-10 Mononucleosis; LUSC cis rs4499344 0.881 rs35447302 chr19:33068499 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.62 -7.92 -0.4 3.47e-14 Mean platelet volume; LUSC cis rs926938 0.527 rs11084 chr1:115537933 A/G cg12756093 chr1:115239321 AMPD1 0.45 6.73 0.35 7.54e-11 Autism; LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.35 0.46 1.3e-18 Prudent dietary pattern; LUSC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg25039879 chr17:56429692 SUPT4H1 0.67 8.85 0.44 5.03e-17 Cognitive test performance; LUSC cis rs2522056 1.000 rs2706395 chr5:131796803 A/T cg24060327 chr5:131705240 SLC22A5 0.45 5.96 0.31 6.39e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs1003719 0.788 rs2835589 chr21:38463342 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs11098499 0.863 rs59732491 chr4:120489588 G/C cg09307838 chr4:120376055 NA 0.75 10.82 0.51 1.32e-23 Corneal astigmatism; LUSC cis rs722599 0.748 rs11623342 chr14:75347937 A/C cg08847533 chr14:75593920 NEK9 -0.49 -7.02 -0.36 1.26e-11 IgG glycosylation; LUSC cis rs9814567 0.806 rs7648616 chr3:134318074 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.39 -0.56 2.9e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs6502050 0.842 rs7211808 chr17:80071244 T/C cg07393940 chr7:158741817 NA -0.37 -6.49 -0.33 3.12e-10 Life satisfaction; LUSC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg06951627 chr6:26196580 NA 0.55 5.88 0.31 1e-8 Gout;Renal underexcretion gout; LUSC cis rs7789940 0.857 rs12532935 chr7:75939698 G/C cg10167463 chr7:75959203 YWHAG -0.58 -8.36 -0.42 1.74e-15 Multiple sclerosis; LUSC cis rs16854884 0.837 rs13083068 chr3:143801642 G/T cg06585982 chr3:143692056 C3orf58 0.43 6.39 0.33 5.48e-10 Economic and political preferences (feminism/equality); LUSC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.39 -5.95 -0.31 6.81e-9 Renal function-related traits (BUN); LUSC cis rs10743315 0.778 rs7397459 chr12:19377578 C/G cg02471346 chr12:19282374 PLEKHA5 0.5 6.38 0.33 5.87e-10 Gut microbiota (bacterial taxa); LUSC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.49 9.55 0.46 2.87e-19 Eosinophil percentage of white cells; LUSC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg11764359 chr7:65958608 NA 0.62 9.41 0.46 8.33e-19 Aortic root size; LUSC cis rs12681288 0.862 rs7015529 chr8:1020249 A/G cg04851639 chr8:1020857 NA -0.4 -8.3 -0.41 2.6e-15 Schizophrenia; LUSC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.02 0.31 4.51e-9 Schizophrenia; LUSC cis rs804280 0.509 rs9886639 chr8:11784529 G/T cg21775007 chr8:11205619 TDH 0.46 6.61 0.34 1.57e-10 Myopia (pathological); LUSC cis rs4478037 1.000 rs4074415 chr3:33161745 A/G cg19404215 chr3:33155277 CRTAP 0.83 8.85 0.44 5.15e-17 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19156104 chr2:198669113 PLCL1 -0.39 -5.99 -0.31 5.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9300255 0.664 rs28636834 chr12:123871070 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.4 6.04 0.31 4.01e-9 Neutrophil percentage of white cells; LUSC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg03351412 chr1:154909251 PMVK 0.53 8.35 0.42 1.9e-15 Prostate cancer; LUSC cis rs1670533 1.000 rs2045065 chr4:1052488 A/G cg02018176 chr4:1364513 KIAA1530 0.44 6.15 0.32 2.16e-9 Recombination rate (females); LUSC cis rs3806843 0.569 rs753279 chr5:140023818 A/G cg19875535 chr5:140030758 IK -0.42 -6.96 -0.36 1.81e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs7119 0.717 rs12916822 chr15:77818548 G/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.61 -0.34 1.53e-10 Type 2 diabetes; LUSC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg09491104 chr22:46646882 C22orf40 -0.66 -7.26 -0.37 2.69e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg24562669 chr7:97807699 LMTK2 0.39 6.67 0.34 1.08e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs77686669 1 rs77686669 chr7:99744572 T/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.4 5.79 0.3 1.62e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs10911232 0.507 rs7515822 chr1:183037803 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 10.95 0.51 4.59e-24 Hypertriglyceridemia; LUSC cis rs929354 0.651 rs6951298 chr7:156949149 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC cis rs7827545 0.545 rs4909477 chr8:135562976 A/G cg17885191 chr8:135476712 NA 0.61 7.82 0.39 6.87e-14 Hypertension (SNP x SNP interaction); LUSC cis rs4711350 0.765 rs756139 chr6:33755541 G/A cg18005901 chr6:33739558 LEMD2 -0.39 -5.65 -0.3 3.38e-8 Schizophrenia; LUSC trans rs1997103 0.954 rs1917769 chr7:55392325 T/A cg20935933 chr6:143382018 AIG1 0.5 7.18 0.37 4.55e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg06627628 chr2:24431161 ITSN2 -0.6 -7.21 -0.37 3.78e-12 Lymphocyte counts; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg04102586 chr1:100435512 SLC35A3 0.66 6.04 0.31 4.21e-9 Body mass index; LUSC cis rs500891 0.553 rs2000375 chr6:84169965 A/G cg08257003 chr6:84140564 ME1 0.36 8.79 0.43 7.82e-17 Platelet-derived growth factor BB levels; LUSC trans rs156299 0.526 rs34942629 chr7:24193160 C/T cg06529468 chr19:10676722 KRI1 0.38 6.2 0.32 1.7e-9 Vitamin D levels; LUSC cis rs10911232 0.507 rs10911222 chr1:183047363 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.95 0.51 4.59e-24 Hypertriglyceridemia; LUSC cis rs2625529 0.627 rs11858015 chr15:72552492 G/A cg16672083 chr15:72433130 SENP8 -0.49 -7.23 -0.37 3.32e-12 Red blood cell count; LUSC cis rs2625529 0.824 rs35167572 chr15:72378960 A/G cg16672083 chr15:72433130 SENP8 -0.52 -7.63 -0.39 2.45e-13 Red blood cell count; LUSC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg12963246 chr6:28129442 ZNF389 0.39 6.03 0.31 4.29e-9 Parkinson's disease; LUSC cis rs870825 0.860 rs72689284 chr4:185596680 A/G cg04058563 chr4:185651563 MLF1IP 0.84 11.99 0.55 8.48e-28 Blood protein levels; LUSC cis rs12208915 0.945 rs116984077 chr6:79583325 A/G cg05283184 chr6:79620031 NA 0.46 6.0 0.31 5.19e-9 Left atrial antero-posterior diameter; LUSC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg07636037 chr3:49044803 WDR6 1.06 19.1 0.72 1.68e-55 Parkinson's disease; LUSC cis rs17401966 0.931 rs61778401 chr1:10426474 G/A cg19773385 chr1:10388646 KIF1B -0.57 -9.86 -0.47 2.77e-20 Hepatocellular carcinoma; LUSC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.17 0.32 2.03e-9 Height; LUSC cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg06064525 chr11:970664 AP2A2 -0.48 -10.44 -0.5 2.96e-22 Alzheimer's disease (late onset); LUSC cis rs6714788 0.546 rs12712062 chr2:100654307 A/T cg22139774 chr2:100720529 AFF3 -0.38 -6.04 -0.31 4.2e-9 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.537 rs13264586 chr8:9979385 T/C cg06636001 chr8:8085503 FLJ10661 0.49 7.14 0.36 5.98e-12 Neuroticism; LUSC cis rs1395 0.744 rs57881048 chr2:27474165 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.57 0.38 3.75e-13 Blood metabolite levels; LUSC cis rs644799 1.000 rs473155 chr11:95596873 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.75 10.95 0.51 4.59e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.59 0.43 3.5e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12711979 0.513 rs1454241 chr2:3851675 A/G cg17052675 chr2:3827356 NA 0.37 6.24 0.32 1.35e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg00750074 chr16:89608354 SPG7 0.38 6.29 0.33 9.86e-10 Multiple myeloma (IgH translocation); LUSC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg01802117 chr1:53393560 SCP2 0.39 6.36 0.33 6.52e-10 Monocyte count; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg00108277 chr3:49840710 C3orf54 0.45 6.22 0.32 1.52e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11190604 1.000 rs7477246 chr10:102261538 C/T cg16342193 chr10:102329863 NA -0.33 -5.85 -0.3 1.17e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2795502 0.882 rs2744091 chr10:43339441 A/G cg27426351 chr10:43362370 NA -0.42 -5.8 -0.3 1.51e-8 Blood protein levels; LUSC cis rs6545883 0.894 rs2600660 chr2:61549600 G/T cg15711740 chr2:61764176 XPO1 0.46 6.85 0.35 3.54e-11 Tuberculosis; LUSC cis rs7100689 0.646 rs1934694 chr10:82125325 G/A cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs62458065 0.513 rs787216 chr7:32578891 G/A cg20159608 chr7:32802032 NA -0.7 -9.12 -0.45 7.4e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs6977660 0.714 rs9969171 chr7:19827328 T/C cg07541023 chr7:19748670 TWISTNB 0.59 6.14 0.32 2.39e-9 Thyroid stimulating hormone; LUSC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg11764359 chr7:65958608 NA -0.69 -10.46 -0.5 2.43e-22 Aortic root size; LUSC cis rs9296092 0.538 rs9469487 chr6:33516943 G/T cg13560919 chr6:33536144 NA -0.82 -15.73 -0.65 4.29e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg12432903 chr7:1882776 MAD1L1 -0.51 -8.76 -0.43 1.01e-16 Bipolar disorder and schizophrenia; LUSC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg03517284 chr6:25882590 NA -0.4 -7.06 -0.36 9.88e-12 Height; LUSC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg15744005 chr10:104629667 AS3MT -0.28 -6.05 -0.31 3.84e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs96067 0.805 rs3767705 chr1:36602044 A/T cg24686825 chr1:36642396 MAP7D1 -0.54 -7.33 -0.37 1.76e-12 Corneal structure; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.11 -0.32 2.78e-9 Total body bone mineral density; LUSC cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.38 0.69 1.15e-48 Chronic sinus infection; LUSC cis rs372883 0.638 rs117213 chr21:30720536 G/A cg08807101 chr21:30365312 RNF160 -0.69 -10.87 -0.51 8.77e-24 Pancreatic cancer; LUSC cis rs9611565 0.694 rs11090056 chr22:42095904 A/C cg17376030 chr22:41985996 PMM1 -0.44 -5.85 -0.3 1.19e-8 Vitiligo; LUSC cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg24692254 chr21:30365293 RNF160 -0.79 -14.22 -0.61 3.17e-36 Dental caries; LUSC cis rs10740039 0.883 rs10761542 chr10:62415223 T/A cg18175470 chr10:62150864 ANK3 -0.46 -6.96 -0.36 1.83e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.36 -5.91 -0.31 8.54e-9 Total body bone mineral density; LUSC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg08677398 chr8:58056175 NA 0.41 5.73 0.3 2.19e-8 Developmental language disorder (linguistic errors); LUSC cis rs11122272 0.735 rs11122281 chr1:231519842 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.76 -0.47 5.93e-20 Hemoglobin concentration; LUSC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -10.04 -0.48 6.9e-21 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.0 -0.36 1.38e-11 Bipolar disorder; LUSC cis rs6960043 0.714 rs7784091 chr7:15047637 A/G cg19272540 chr7:15055459 NA -0.34 -8.66 -0.43 1.99e-16 Type 2 diabetes; LUSC cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg04450456 chr4:17643702 FAM184B 0.38 6.28 0.32 1.05e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 6.99e-41 Breast cancer; LUSC cis rs2932538 0.922 rs6690169 chr1:113114974 A/G cg22162597 chr1:113214053 CAPZA1 0.7 10.0 0.48 9.16e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19862838 chr3:101396008 ZBTB11;LOC100009676 -0.38 -5.97 -0.31 5.92e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11098499 0.604 rs12642411 chr4:120580525 T/C cg09307838 chr4:120376055 NA 0.7 9.88 0.48 2.23e-20 Corneal astigmatism; LUSC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg04450456 chr4:17643702 FAM184B 0.38 6.41 0.33 5.02e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12421382 0.615 rs11607972 chr11:109392155 A/G cg16359550 chr11:109292809 C11orf87 0.37 6.33 0.33 7.74e-10 Schizophrenia; LUSC cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg03264133 chr6:25882463 NA -0.5 -9.04 -0.44 1.33e-17 Blood metabolite levels; LUSC cis rs951366 0.576 rs7513645 chr1:205698026 A/G cg24503407 chr1:205819492 PM20D1 0.48 6.42 0.33 4.56e-10 Menarche (age at onset); LUSC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2050392 0.965 rs2265371 chr10:30690840 C/T cg18806716 chr10:30721971 MAP3K8 -0.44 -7.14 -0.36 5.8e-12 Inflammatory bowel disease; LUSC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg13206674 chr6:150067644 NUP43 0.57 8.94 0.44 2.75e-17 Lung cancer; LUSC cis rs4820294 1.000 rs739139 chr22:38067011 C/G cg21798802 chr22:38057573 PDXP 0.48 10.64 0.5 6.02e-23 Fat distribution (HIV); LUSC cis rs1372520 0.684 rs1442148 chr4:90748846 T/A cg01966878 chr4:90757139 SNCA -0.42 -5.96 -0.31 6.24e-9 Neuroticism; LUSC cis rs4812048 0.793 rs6070693 chr20:57589516 C/T cg14073986 chr20:57617431 SLMO2 0.66 6.3 0.33 9.41e-10 Mean platelet volume; LUSC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg14784868 chr12:69753453 YEATS4 0.82 13.97 0.61 2.99e-35 Blood protein levels; LUSC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg25282410 chr6:160211355 TCP1;MRPL18 1.19 21.53 0.76 4.41e-65 Age-related macular degeneration (geographic atrophy); LUSC cis rs9398803 0.865 rs9401883 chr6:126797111 A/G cg19875578 chr6:126661172 C6orf173 0.43 6.37 0.33 6.18e-10 Male-pattern baldness; LUSC cis rs4242434 0.672 rs10099266 chr8:22484268 C/G cg03733263 chr8:22462867 KIAA1967 0.74 12.09 0.55 3.59e-28 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2072499 0.932 rs2540183 chr1:156164885 C/G cg24450063 chr1:156163899 SLC25A44 1.17 24.47 0.8 1.76e-76 Testicular germ cell tumor; LUSC trans rs870142 0.922 rs4689908 chr4:4637516 T/A cg04017672 chr1:182359056 GLUL 0.41 6.12 0.32 2.59e-9 Congenital heart disease; LUSC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg18681998 chr4:17616180 MED28 0.9 17.84 0.7 1.85e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg20503657 chr10:835505 NA 1.22 16.41 0.67 8.56e-45 Eosinophil percentage of granulocytes; LUSC cis rs865483 0.895 rs853229 chr17:35800919 A/G cg06716730 chr17:35851459 DUSP14 0.27 5.91 0.31 8.66e-9 Monocyte count; LUSC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg21918786 chr6:109611834 NA -0.36 -6.25 -0.32 1.25e-9 Reticulocyte fraction of red cells; LUSC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg00343986 chr7:65444356 GUSB -0.38 -5.71 -0.3 2.46e-8 Aortic root size; LUSC cis rs694739 0.857 rs574835 chr11:64110668 G/A cg23796481 chr11:64053134 BAD;GPR137 0.6 9.75 0.47 6.13e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg24296786 chr1:45957014 TESK2 -0.51 -7.58 -0.38 3.46e-13 High light scatter reticulocyte count; LUSC cis rs7772486 0.742 rs4896851 chr6:146278959 T/C cg05347473 chr6:146136440 FBXO30 -0.49 -8.03 -0.4 1.66e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.19 -0.37 4.24e-12 Alzheimer's disease (late onset); LUSC cis rs983392 0.805 rs1834550 chr11:59959843 T/C cg20284999 chr11:59952153 MS4A6A -0.39 -6.35 -0.33 7.23e-10 Alzheimer's disease (late onset); LUSC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg00944433 chr1:107599041 PRMT6 -0.34 -6.24 -0.32 1.35e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs754466 0.580 rs1058198 chr10:79566632 G/A cg17075019 chr10:79541650 NA -0.69 -10.44 -0.5 2.78e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05756109 chr10:103347662 POLL;RP11-529I10.4 -0.41 -6.24 -0.32 1.32e-9 Hepatitis; LUSC trans rs4714291 0.775 rs2949019 chr6:40051200 C/T cg02267698 chr19:7991119 CTXN1 -0.55 -8.26 -0.41 3.4e-15 Strep throat; LUSC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg04944784 chr2:26401820 FAM59B -0.69 -9.63 -0.47 1.59e-19 Gut microbiome composition (summer); LUSC cis rs10186029 0.680 rs4673726 chr2:213981115 T/C cg08319019 chr2:214017104 IKZF2 0.6 8.66 0.43 1.99e-16 Systemic sclerosis; LUSC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -7.34 -0.37 1.61e-12 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs4774899 0.837 rs10518894 chr15:57403598 C/T cg21617494 chr15:57618479 NA -0.35 -5.9 -0.31 9.06e-9 Urinary tract infection frequency; LUSC cis rs17661538 0.504 rs35769984 chr10:18436542 A/G cg03634479 chr10:18430412 CACNB2 0.69 6.61 0.34 1.53e-10 Response to antipsychotic treatment; LUSC cis rs9650657 0.562 rs10090444 chr8:10745469 C/G cg21775007 chr8:11205619 TDH 0.51 7.0 0.36 1.42e-11 Neuroticism; LUSC cis rs79911532 0.515 rs115332207 chr7:75635405 G/A cg03592824 chr7:75666768 STYXL1 0.7 7.04 0.36 1.12e-11 Mononucleosis; LUSC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg15445000 chr17:37608096 MED1 -0.41 -6.87 -0.35 3.18e-11 Glomerular filtration rate (creatinine); LUSC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg03929089 chr4:120376271 NA 0.83 12.24 0.56 1.07e-28 Coronary artery disease; LUSC cis rs4242434 0.854 rs3735893 chr8:22452704 A/G cg03733263 chr8:22462867 KIAA1967 1.0 18.93 0.72 8.06e-55 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs72634258 0.945 rs12748993 chr1:8129507 A/G cg00042356 chr1:8021962 PARK7 0.72 9.19 0.45 4.15e-18 Inflammatory bowel disease; LUSC cis rs11098499 0.863 rs9884402 chr4:120489982 A/G cg24375607 chr4:120327624 NA 0.76 11.48 0.53 6.02e-26 Corneal astigmatism; LUSC cis rs9341808 0.600 rs590641 chr6:80966483 A/G cg08355045 chr6:80787529 NA 0.41 6.84 0.35 3.73e-11 Sitting height ratio; LUSC cis rs12042938 0.905 rs823160 chr1:231776636 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 5.97 0.31 5.94e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs2733201 1.000 rs1426658 chr15:44338919 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.75 -5.71 -0.3 2.49e-8 Lipoprotein phospholipase A2 activity in cardiovascular disease; LUSC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg17971929 chr21:40555470 PSMG1 0.77 13.53 0.6 1.44e-33 Cognitive function; LUSC cis rs9303401 0.659 rs36109237 chr17:56653834 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC cis rs870825 0.616 rs2090590 chr4:185647850 A/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs10493773 0.609 rs11161660 chr1:86184066 C/T cg17807903 chr1:86174739 ZNHIT6 -0.54 -14.71 -0.63 3.96e-38 Urate levels in overweight individuals; LUSC cis rs11168618 0.846 rs11168586 chr12:48854012 C/T cg24011408 chr12:48396354 COL2A1 0.37 5.78 0.3 1.7e-8 Adiponectin levels; LUSC cis rs950169 0.922 rs12910334 chr15:84958318 G/A cg17173187 chr15:85201210 NMB 0.39 6.94 0.35 2.07e-11 Schizophrenia; LUSC cis rs2354432 0.607 rs9661159 chr1:146757923 G/A cg25205988 chr1:146714368 CHD1L -1.04 -9.45 -0.46 6.22e-19 Mitochondrial DNA levels; LUSC trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs997295 0.529 rs12592315 chr15:68040266 A/G cg08079166 chr15:68083412 MAP2K5 -0.35 -7.01 -0.36 1.29e-11 Motion sickness; LUSC cis rs911119 0.818 rs67862677 chr20:23591086 A/C cg16589663 chr20:23618590 CST3 0.61 7.29 0.37 2.32e-12 Chronic kidney disease; LUSC cis rs2361710 0.668 rs4889830 chr17:78114528 G/A cg20811857 chr17:78079795 GAA -0.32 -6.0 -0.31 5.16e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs8028313 0.630 rs12900208 chr15:67963058 C/G cg05925327 chr15:68127851 NA -0.43 -6.54 -0.34 2.26e-10 Obesity; LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg16393715 chr7:1948819 MAD1L1 0.34 5.82 0.3 1.35e-8 Bipolar disorder and schizophrenia; LUSC cis rs7246967 0.611 rs2361022 chr19:22816533 A/G cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC trans rs7824557 0.602 rs35807737 chr8:11204411 C/G cg06636001 chr8:8085503 FLJ10661 0.45 6.42 0.33 4.57e-10 Retinal vascular caliber; LUSC cis rs3771570 1.000 rs56156035 chr2:242205955 T/A cg21155796 chr2:242212141 HDLBP 0.68 7.52 0.38 5.12e-13 Prostate cancer; LUSC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.48 8.13 0.41 8.59e-15 Vitiligo; LUSC cis rs17826219 0.636 rs8080829 chr17:29058730 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Body mass index; LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs6121246 0.909 rs7354225 chr20:30296881 C/T cg13852791 chr20:30311386 BCL2L1 0.95 12.12 0.55 2.92e-28 Mean corpuscular hemoglobin; LUSC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg13902645 chr11:5959945 NA 0.57 9.52 0.46 3.59e-19 DNA methylation (variation); LUSC cis rs3096299 0.606 rs2965960 chr16:89541795 G/A cg16743903 chr16:89593216 SPG7 -0.44 -6.09 -0.32 3.09e-9 Multiple myeloma (IgH translocation); LUSC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg02569458 chr12:86230093 RASSF9 0.52 8.64 0.43 2.3e-16 Major depressive disorder; LUSC cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs6005807 0.719 rs134547 chr22:28801009 A/G cg12565055 chr22:29076175 TTC28 0.52 5.82 0.3 1.38e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC trans rs12571093 0.803 rs61854814 chr10:70027396 A/G cg04882175 chr6:131122610 NA -0.55 -6.36 -0.33 6.49e-10 Optic nerve measurement (disc area); LUSC cis rs10740039 0.516 rs10761526 chr10:62354419 T/C cg18175470 chr10:62150864 ANK3 -0.47 -6.94 -0.36 2.04e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2204008 0.571 rs7970136 chr12:38531951 G/C cg26384229 chr12:38710491 ALG10B -0.55 -8.27 -0.41 3.3e-15 Bladder cancer; LUSC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg03161606 chr19:29218774 NA 0.52 6.76 0.35 6.23e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs10089 1.000 rs72794392 chr5:127490061 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 10.43 0.5 3.18e-22 Ileal carcinoids; LUSC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg18252515 chr7:66147081 NA -1.24 -13.69 -0.6 3.59e-34 Diabetic kidney disease; LUSC cis rs34779708 0.733 rs7914468 chr10:35548071 G/A cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg13770153 chr20:60521292 NA -0.62 -8.39 -0.42 1.36e-15 Body mass index; LUSC cis rs1784581 0.894 rs1790001 chr6:162387504 G/T cg17173639 chr6:162384350 PARK2 -0.82 -15.64 -0.65 9.6e-42 Itch intensity from mosquito bite; LUSC cis rs7523050 0.643 rs34367763 chr1:109400805 C/T cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC cis rs12973672 0.812 rs10419959 chr19:35764705 G/A cg12095397 chr19:35769544 USF2 0.45 6.77 0.35 5.92e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4780355 0.843 rs413024 chr16:11354091 A/G cg00044050 chr16:11439710 C16orf75 0.59 8.71 0.43 1.42e-16 Crohn's disease and psoriasis; LUSC trans rs7647973 0.710 rs6446285 chr3:49626306 G/A cg21659725 chr3:3221576 CRBN -0.72 -7.62 -0.38 2.66e-13 Menarche (age at onset); LUSC cis rs7100689 0.622 rs7082093 chr10:82134954 T/G cg01528321 chr10:82214614 TSPAN14 0.87 13.03 0.58 1.14e-31 Post bronchodilator FEV1; LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.15 0.32 2.16e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg02423579 chr7:2872169 GNA12 -0.37 -5.75 -0.3 2.03e-8 Height; LUSC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.33 0.69 1.95e-48 Chronic sinus infection; LUSC cis rs11792861 0.926 rs17729523 chr9:111773317 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -7.65 -0.39 2.12e-13 Menarche (age at onset); LUSC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.11 0.32 2.79e-9 Schizophrenia; LUSC cis rs9814567 0.722 rs13083717 chr3:134348796 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.86 12.36 0.56 3.64e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs10411161 0.752 rs10402107 chr19:52384600 A/G cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs8014204 0.533 rs12434646 chr14:75178693 C/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.28 0.41 3.1e-15 Caffeine consumption; LUSC cis rs6542838 0.702 rs4851177 chr2:99535188 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.04 -0.36 1.1e-11 Fear of minor pain; LUSC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -12.67 -0.57 2.58e-30 Hemoglobin concentration; LUSC cis rs9341835 0.681 rs9352960 chr6:64150426 C/G cg03326410 chr6:64151739 NA -0.37 -6.13 -0.32 2.53e-9 Schizophrenia; LUSC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg20203395 chr5:56204925 C5orf35 -0.75 -10.33 -0.49 6.65e-22 Initial pursuit acceleration; LUSC cis rs11640436 0.565 rs1594051 chr16:77307040 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.37 5.71 0.3 2.51e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2274273 0.688 rs6573001 chr14:55556502 A/G cg04306507 chr14:55594613 LGALS3 0.52 11.31 0.53 2.49e-25 Protein biomarker; LUSC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.11 -0.32 2.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12291225 0.585 rs10832242 chr11:14340504 C/T cg05501817 chr11:14380813 RRAS2 0.56 9.23 0.45 3.27e-18 Sense of smell; LUSC trans rs17685 0.753 rs6465000 chr7:75787417 G/A cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs727505 0.607 rs67680878 chr7:124787381 G/A cg23710748 chr7:124431027 NA -0.4 -6.92 -0.35 2.31e-11 Lewy body disease; LUSC cis rs791888 0.858 rs2180968 chr10:89418730 A/C cg10377144 chr10:89419177 PAPSS2 0.25 5.66 0.3 3.32e-8 Magnesium levels; LUSC cis rs9640161 0.636 rs3735171 chr7:150033882 A/G cg17279839 chr7:150038598 RARRES2 0.51 7.82 0.39 7.21e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs6547741 1.000 rs6547741 chr2:27855924 G/A cg12559939 chr2:27858050 GPN1 0.41 6.33 0.33 8.01e-10 Oral cavity cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08608532 chr13:100741163 PCCA -0.39 -5.98 -0.31 5.7e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg20818283 chr2:191399100 TMEM194B -0.42 -6.54 -0.34 2.25e-10 Pulse pressure; LUSC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg00012203 chr2:219082015 ARPC2 -0.69 -11.26 -0.52 3.77e-25 Colorectal cancer; LUSC cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg24450063 chr1:156163899 SLC25A44 1.18 29.21 0.85 5.44e-94 Testicular germ cell tumor; LUSC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg15468180 chr1:107600409 PRMT6 0.41 6.54 0.34 2.32e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg06873352 chr17:61820015 STRADA -0.7 -12.54 -0.57 8.25e-30 Prudent dietary pattern; LUSC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg08847533 chr14:75593920 NEK9 0.85 15.6 0.65 1.32e-41 Height; LUSC cis rs6489882 0.902 rs3759375 chr12:113373588 A/G cg20102336 chr12:113376681 OAS3 -0.42 -6.03 -0.31 4.29e-9 Chronic lymphocytic leukemia; LUSC cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg26769984 chr7:1090371 C7orf50 0.59 7.93 0.4 3.43e-14 Bronchopulmonary dysplasia; LUSC cis rs12760731 0.565 rs34303391 chr1:178178126 T/A cg00404053 chr1:178313656 RASAL2 0.66 6.82 0.35 4.26e-11 Obesity-related traits; LUSC trans rs7939886 0.920 rs7936219 chr11:55977335 C/T cg15704280 chr7:45808275 SEPT13 0.91 6.86 0.35 3.36e-11 Myopia (pathological); LUSC cis rs2281845 0.826 rs4915214 chr1:201076290 T/A cg17810781 chr1:201082982 CACNA1S 0.3 5.69 0.3 2.77e-8 Permanent tooth development; LUSC cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.38 0.69 1.15e-48 Chronic sinus infection; LUSC cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 18.34 0.71 1.9e-52 Chronic sinus infection; LUSC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg04369109 chr6:150039330 LATS1 -0.54 -8.05 -0.4 1.51e-14 Lung cancer; LUSC cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg24642439 chr20:33292090 TP53INP2 0.48 7.24 0.37 3.14e-12 Glomerular filtration rate (creatinine); LUSC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg16339924 chr4:17578868 LAP3 0.52 7.78 0.39 9.09e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg24642439 chr20:33292090 TP53INP2 0.68 10.76 0.51 2.15e-23 Coronary artery disease; LUSC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.11 -0.41 9.95e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.546 rs7699578 chr4:98838893 T/C cg17366294 chr4:99064904 C4orf37 0.59 8.61 0.43 2.83e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs500891 0.574 rs1112482 chr6:84112019 G/C cg08257003 chr6:84140564 ME1 0.34 7.6 0.38 3.06e-13 Platelet-derived growth factor BB levels; LUSC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg07701084 chr6:150067640 NUP43 0.49 7.34 0.37 1.68e-12 Lung cancer; LUSC cis rs12477438 0.765 rs2309521 chr2:99592069 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.75 -0.51 2.45e-23 Chronic sinus infection; LUSC cis rs17152411 1.000 rs12355869 chr10:126645231 G/T cg07906193 chr10:126599966 NA 0.42 5.83 0.3 1.29e-8 Height; LUSC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg23711669 chr6:146136114 FBXO30 0.85 15.37 0.64 1.06e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg13256891 chr4:100009986 ADH5 -0.43 -5.94 -0.31 7.28e-9 Alcohol dependence; LUSC cis rs1030877 0.515 rs17030766 chr2:105911905 G/A cg02079111 chr2:105885981 TGFBRAP1 -0.52 -6.77 -0.35 5.88e-11 Obesity-related traits; LUSC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.49 -7.68 -0.39 1.81e-13 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11051970 0.594 rs325418 chr12:32572517 T/C cg02745156 chr12:32552066 NA 0.38 6.9 0.35 2.67e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10097731 0.901 rs10464932 chr8:82042901 T/G cg25230327 chr8:82042993 NA -0.48 -6.78 -0.35 5.55e-11 Serum total protein level; LUSC cis rs60733400 0.782 rs4648564 chr1:2562169 C/T cg18932078 chr1:2524107 MMEL1 -0.31 -6.76 -0.35 6.14e-11 Multiple sclerosis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14387532 chr2:232571819 PTMA 0.75 5.95 0.31 6.87e-9 Cognitive performance; LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.83 0.63 1.46e-38 Platelet count; LUSC cis rs1322512 0.713 rs1744387 chr6:152939439 A/G cg27316956 chr6:152958899 SYNE1 -0.35 -5.8 -0.3 1.58e-8 Tonometry; LUSC cis rs9648716 0.515 rs71645993 chr7:140434845 T/C cg23214464 chr7:140373596 ADCK2 0.78 6.26 0.32 1.17e-9 Type 2 diabetes; LUSC trans rs9929218 0.529 rs35854485 chr16:68730855 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 22.58 0.78 3.49e-69 Colorectal cancer; LUSC cis rs11048434 0.736 rs11048344 chr12:9122609 G/C cg04155231 chr12:9217510 LOC144571 0.31 5.68 0.3 3e-8 Sjögren's syndrome; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg11645453 chr3:52864694 ITIH4 0.31 7.31 0.37 2.04e-12 Electroencephalogram traits; LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC trans rs12210905 1.000 rs10946906 chr6:27252780 G/A cg18180407 chr1:55047736 ACOT11 0.54 5.98 0.31 5.71e-9 Hip circumference adjusted for BMI; LUSC cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.26 -0.37 2.81e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg06112835 chr11:68658793 MRPL21 0.51 8.09 0.4 1.1e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC cis rs8113142 0.690 rs4805256 chr19:29109359 T/C cg04546413 chr19:29218101 NA 0.43 5.91 0.31 8.43e-9 Femoral neck bone geometry and menarche (age at onset); LUSC trans rs9329221 0.638 rs7460436 chr8:10254322 C/T cg08975724 chr8:8085496 FLJ10661 0.46 5.96 0.31 6.26e-9 Neuroticism; LUSC cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg07703079 chr11:430292 ANO9 0.67 7.08 0.36 8.45e-12 Body mass index; LUSC cis rs2227564 0.620 rs10740418 chr10:75519322 T/C cg23231163 chr10:75533350 FUT11 -0.44 -6.56 -0.34 2.11e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg14844989 chr11:31128820 NA -0.36 -5.68 -0.3 2.95e-8 Red blood cell count; LUSC trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg06636001 chr8:8085503 FLJ10661 0.6 8.98 0.44 1.97e-17 Neuroticism; LUSC cis rs3761218 0.738 rs4815604 chr20:3772913 C/T cg02737268 chr20:3780182 CDC25B 0.35 6.93 0.35 2.19e-11 Bipolar disorder; LUSC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg02034447 chr16:89574710 SPG7 0.4 5.97 0.31 5.9e-9 Multiple myeloma (IgH translocation); LUSC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg00255919 chr5:131827918 IRF1 0.41 7.93 0.4 3.36e-14 Asthma (sex interaction); LUSC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg08847533 chr14:75593920 NEK9 -0.79 -13.57 -0.6 1e-33 Height; LUSC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg08219700 chr8:58056026 NA 0.66 7.44 0.38 8.4e-13 Developmental language disorder (linguistic errors); LUSC cis rs2625529 0.824 rs55854204 chr15:72433182 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.47 -0.38 7.17e-13 Red blood cell count; LUSC cis rs12541635 0.966 rs12680670 chr8:107006811 T/G cg10147462 chr8:107024639 NA 0.55 9.97 0.48 1.16e-20 Age of smoking initiation; LUSC cis rs2625529 0.824 rs4238449 chr15:72421603 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.54 -0.38 4.48e-13 Red blood cell count; LUSC cis rs6489785 0.521 rs668622 chr12:121198299 G/A cg02419362 chr12:121203948 SPPL3 0.38 6.8 0.35 4.84e-11 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9788682 1.000 rs7163730 chr15:78814681 A/G cg24631222 chr15:78858424 CHRNA5 0.83 11.64 0.54 1.6e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs3730682 0.901 rs59788851 chr18:51778362 G/A cg04730925 chr18:51795821 POLI 0.43 5.8 0.3 1.54e-8 Psoriasis; LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs3862435 0.764 rs28545005 chr15:90954131 A/G cg22089800 chr15:90895588 ZNF774 0.58 6.32 0.33 8.53e-10 Response to exercise (triglyceride level interaction); LUSC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg20283391 chr11:68216788 NA -0.54 -8.23 -0.41 4.33e-15 Total body bone mineral density; LUSC cis rs13256369 0.950 rs13255655 chr8:8577736 C/T cg00074818 chr8:8560427 CLDN23 0.57 8.95 0.44 2.57e-17 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13999099 chr5:55290899 IL6ST 0.42 5.95 0.31 6.95e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs67539049 1.000 rs7832089 chr8:11306003 C/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.42 -6.47 -0.33 3.48e-10 Itch intensity from mosquito bite; LUSC cis rs12760731 0.623 rs10913556 chr1:178436678 C/T cg00404053 chr1:178313656 RASAL2 0.43 5.65 0.3 3.52e-8 Obesity-related traits; LUSC cis rs9517313 0.897 rs4772087 chr13:99115041 A/G cg20487152 chr13:99095054 FARP1 0.44 7.96 0.4 2.8e-14 Neuroticism; LUSC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg08470875 chr2:26401718 FAM59B 0.67 8.34 0.42 1.99e-15 Gut microbiome composition (summer); LUSC cis rs2236918 0.710 rs2797603 chr1:242029027 T/G cg17736920 chr1:242011382 EXO1 0.42 6.61 0.34 1.52e-10 Menopause (age at onset); LUSC cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg19196401 chr6:110721138 DDO -0.45 -8.46 -0.42 8.59e-16 Platelet distribution width; LUSC cis rs11252926 0.625 rs7903876 chr10:482678 T/C cg18196295 chr10:418757 DIP2C -0.47 -7.78 -0.39 8.91e-14 Psychosis in Alzheimer's disease; LUSC cis rs12122100 0.955 rs12141289 chr1:146509468 A/G cg03526459 chr1:146549940 NA -0.41 -6.71 -0.34 8.23e-11 HIV-1 control; LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg11766577 chr21:47581405 C21orf56 0.47 7.09 0.36 8.02e-12 Testicular germ cell tumor; LUSC cis rs7824557 0.701 rs2060465 chr8:11162609 T/C cg21293242 chr8:11204541 TDH 0.32 5.96 0.31 6.38e-9 Retinal vascular caliber; LUSC cis rs9902453 0.904 rs12951836 chr17:28410277 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -10.89 -0.51 7.72e-24 Coffee consumption (cups per day); LUSC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg05025164 chr4:1340916 KIAA1530 0.56 8.99 0.44 1.91e-17 Longevity; LUSC cis rs806215 0.950 rs3735642 chr7:127224286 A/G cg25922125 chr7:127225783 GCC1 -0.6 -7.38 -0.37 1.24e-12 Type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16280946 chr22:20716554 NA 0.51 6.11 0.32 2.74e-9 Bipolar disorder and schizophrenia; LUSC cis rs11690935 1.000 rs6757773 chr2:172549630 T/A cg13550731 chr2:172543902 DYNC1I2 0.89 14.93 0.63 5.8e-39 Schizophrenia; LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs6060717 0.536 rs6060669 chr20:34480557 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -6.39 -0.33 5.45e-10 Hip circumference adjusted for BMI; LUSC cis rs11098499 0.865 rs10032158 chr4:120391632 C/T cg24375607 chr4:120327624 NA 0.78 11.49 0.53 5.51e-26 Corneal astigmatism; LUSC cis rs11190604 1.000 rs11190602 chr10:102297256 T/C cg16342193 chr10:102329863 NA -0.36 -6.56 -0.34 2.08e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4660306 0.961 rs7546268 chr1:45965340 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.22 -0.37 3.6e-12 Homocysteine levels; LUSC cis rs765787 0.530 rs4775822 chr15:45527127 A/G cg25801113 chr15:45476975 SHF 0.33 6.9 0.35 2.62e-11 Uric acid levels; LUSC cis rs11167764 1.000 rs7730511 chr5:141480418 T/C cg23435118 chr5:141488016 NDFIP1 -0.56 -7.93 -0.4 3.4e-14 Crohn's disease; LUSC cis rs4919694 1.000 rs12266291 chr10:104806884 G/A cg04362960 chr10:104952993 NT5C2 1.18 13.93 0.61 4.45e-35 Arsenic metabolism; LUSC cis rs68170813 0.559 rs76167266 chr7:106900664 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.05 15.92 0.66 7.33e-43 Age-related macular degeneration (geographic atrophy); LUSC trans rs61931739 0.534 rs4539411 chr12:34014807 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.9 0.51 7.43e-24 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00226754 chr12:124068984 TMED2 -0.51 -6.32 -0.33 8.51e-10 Bipolar disorder and schizophrenia; LUSC cis rs4147929 0.532 rs4147932 chr19:1064485 C/T cg26576206 chr19:1064938 ABCA7 0.44 6.7 0.34 9.06e-11 Alzheimer's disease (late onset); LUSC cis rs9486715 1.000 rs11153082 chr6:97059666 A/G cg06623918 chr6:96969491 KIAA0776 -0.86 -14.29 -0.62 1.69e-36 Headache; LUSC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -8.01 -0.4 1.92e-14 Major depressive disorder; LUSC trans rs853679 0.517 rs9368556 chr6:28131153 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs6545883 0.894 rs4672431 chr2:61519922 C/A cg15711740 chr2:61764176 XPO1 0.44 6.78 0.35 5.44e-11 Tuberculosis; LUSC cis rs2439831 0.717 rs28495368 chr15:43895642 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC cis rs2070488 0.775 rs1073505 chr3:38566722 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.67 -11.89 -0.55 2.01e-27 Electrocardiographic conduction measures; LUSC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg03929089 chr4:120376271 NA -1.04 -20.21 -0.74 7.12e-60 Height; LUSC cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.35 5.77 0.3 1.85e-8 Vitiligo; LUSC cis rs11997175 0.646 rs6993892 chr8:33729200 T/C ch.8.33884649F chr8:33765107 NA 0.49 7.32 0.37 1.89e-12 Body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00419759 chr1:114301964 PHTF1 0.41 6.18 0.32 1.82e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7119 0.635 rs2667764 chr15:77881239 C/T cg27398640 chr15:77910606 LINGO1 0.35 8.2 0.41 5.1e-15 Type 2 diabetes; LUSC cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.89 -0.51 7.77e-24 Alzheimer's disease (late onset); LUSC cis rs7937682 0.593 rs1944121 chr11:111347223 T/C cg09085632 chr11:111637200 PPP2R1B 0.44 5.82 0.3 1.35e-8 Primary sclerosing cholangitis; LUSC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg07959070 chr22:50026188 C22orf34 -0.36 -7.25 -0.37 2.87e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9902453 1.000 rs9906340 chr17:28398977 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -9.01 -0.44 1.63e-17 Coffee consumption (cups per day); LUSC cis rs8060686 0.623 rs7201591 chr16:68086105 A/G cg09835421 chr16:68378352 PRMT7 -0.45 -5.95 -0.31 6.8e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs981844 0.767 rs6857738 chr4:154689140 A/C cg10279832 chr4:154682576 RNF175 0.37 5.91 0.31 8.67e-9 Response to statins (LDL cholesterol change); LUSC cis rs727505 0.563 rs73227531 chr7:124800221 T/A cg23710748 chr7:124431027 NA -0.38 -6.6 -0.34 1.64e-10 Lewy body disease; LUSC cis rs8141529 0.509 rs5762864 chr22:29253364 T/C cg02153584 chr22:29168773 CCDC117 0.55 7.94 0.4 3.01e-14 Lymphocyte counts; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04661747 chr11:46264818 NA 0.47 6.54 0.34 2.28e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs36093844 0.800 rs79349553 chr11:85567836 G/T cg25872744 chr11:85566296 CCDC83 -0.45 -5.78 -0.3 1.74e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.69 -0.39 1.68e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs782590 0.935 rs782568 chr2:55881538 T/C cg18811423 chr2:55921094 PNPT1 0.87 15.49 0.65 3.75e-41 Metabolic syndrome; LUSC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg17252645 chr8:143867129 LY6D 0.38 6.79 0.35 5.28e-11 Urinary tract infection frequency; LUSC trans rs853679 0.882 rs9461432 chr6:28086883 T/C cg01620082 chr3:125678407 NA -0.62 -6.83 -0.35 3.98e-11 Depression; LUSC cis rs2839186 0.786 rs7409792 chr21:47691729 C/A cg13126279 chr21:47581558 C21orf56 -0.47 -7.07 -0.36 9.17e-12 Testicular germ cell tumor; LUSC trans rs561341 0.941 rs7215147 chr17:30266711 G/A cg20587970 chr11:113659929 NA -0.99 -13.28 -0.59 1.27e-32 Hip circumference adjusted for BMI; LUSC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg27494647 chr7:150038898 RARRES2 0.45 6.84 0.35 3.88e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs7523050 0.730 rs11102650 chr1:109464228 C/G cg08274380 chr1:109419600 GPSM2 1.03 10.3 0.49 8.35e-22 Fat distribution (HIV); LUSC cis rs6121246 0.529 rs6060171 chr20:30183269 C/T cg21427119 chr20:30132790 HM13 -0.43 -6.15 -0.32 2.26e-9 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg14019146 chr3:50243930 SLC38A3 -0.32 -7.09 -0.36 8.22e-12 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg22963979 chr7:1858916 MAD1L1 -0.57 -8.84 -0.44 5.78e-17 Bipolar disorder and schizophrenia; LUSC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg27124370 chr19:33622961 WDR88 0.53 7.65 0.39 2.13e-13 Colorectal cancer; LUSC trans rs2980439 0.557 rs2921056 chr8:8319182 T/C cg21775007 chr8:11205619 TDH 0.42 6.01 0.31 4.83e-9 Neuroticism; LUSC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg09703963 chr11:616879 IRF7;MUPCDH -0.46 -7.18 -0.37 4.6e-12 Systemic lupus erythematosus; LUSC cis rs7000551 0.751 rs2469755 chr8:22360212 G/A cg12081754 chr8:22256438 SLC39A14 0.45 6.8 0.35 4.83e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg16230307 chr14:35515116 FAM177A1 0.78 10.0 0.48 8.96e-21 Psoriasis; LUSC cis rs3812831 0.643 rs7322339 chr13:114929726 C/A cg15896084 chr13:114927664 NA 0.4 7.18 0.37 4.42e-12 Schizophrenia; LUSC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg00074818 chr8:8560427 CLDN23 0.58 9.66 0.47 1.23e-19 Obesity-related traits; LUSC cis rs9329221 0.592 rs7832708 chr8:10190040 C/T cg27411982 chr8:10470053 RP1L1 0.54 9.13 0.45 6.6e-18 Neuroticism; LUSC cis rs137699 1.000 rs2049986 chr22:39756854 C/G cg05872129 chr22:39784769 NA 0.36 6.15 0.32 2.21e-9 IgG glycosylation; LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs6547741 0.935 rs12714204 chr2:27787540 T/C cg12559939 chr2:27858050 GPN1 0.38 5.91 0.31 8.6e-9 Oral cavity cancer; LUSC cis rs6736093 1.000 rs6736093 chr2:112655242 C/T cg12686935 chr2:112915763 FBLN7 0.39 6.05 0.31 3.95e-9 Coronary artery disease; LUSC cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg16322792 chr1:120165303 ZNF697 0.74 15.64 0.65 9.03e-42 Systemic lupus erythematosus; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg25767906 chr1:53392781 SCP2 -0.53 -10.33 -0.49 7.07e-22 Monocyte count; LUSC cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg08807101 chr21:30365312 RNF160 -0.67 -11.54 -0.53 3.59e-26 Dental caries; LUSC cis rs929354 0.742 rs10274687 chr7:156933181 T/G cg05182265 chr7:156933206 UBE3C -0.59 -9.44 -0.46 6.62e-19 Body mass index; LUSC cis rs2455601 0.882 rs11042106 chr11:8896083 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.51 8.57 0.42 4.01e-16 Schizophrenia; LUSC cis rs2742234 0.541 rs61268333 chr10:43721370 G/A cg02780029 chr10:43622663 RET 0.35 5.82 0.3 1.41e-8 Hirschsprung disease; LUSC cis rs4969178 0.896 rs11077361 chr17:76397128 A/G cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs734999 0.505 rs10797438 chr1:2540262 C/T cg18932078 chr1:2524107 MMEL1 0.28 6.15 0.32 2.18e-9 Ulcerative colitis; LUSC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg12292205 chr6:26970375 C6orf41 -0.7 -12.22 -0.56 1.23e-28 Autism spectrum disorder or schizophrenia; LUSC trans rs13314892 1.000 rs13314892 chr3:69795052 A/G cg14672293 chr2:48542674 FOXN2 0.48 6.01 0.31 4.78e-9 QRS complex (12-leadsum); LUSC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg06008330 chr7:65541103 ASL 0.4 6.24 0.32 1.32e-9 Aortic root size; LUSC cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg26597838 chr10:835615 NA -0.5 -6.75 -0.35 6.65e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs476633 0.691 rs2164996 chr15:41536624 A/G cg18705301 chr15:41695430 NDUFAF1 -0.49 -8.66 -0.43 2.03e-16 Glomerular filtration rate (creatinine); LUSC cis rs79349575 0.715 rs9894220 chr17:46989154 C/T cg22482690 chr17:47019901 SNF8 0.34 6.35 0.33 6.85e-10 Type 2 diabetes; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg14092988 chr3:52407081 DNAH1 0.32 5.94 0.31 7.16e-9 Bipolar disorder; LUSC cis rs7914558 0.933 rs2066323 chr10:104871361 A/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.06 -0.36 9.84e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9326248 0.581 rs10790167 chr11:116800943 T/C cg11861562 chr11:117069780 TAGLN 0.35 6.73 0.35 7.59e-11 Blood protein levels; LUSC cis rs11190604 1.000 rs7088827 chr10:102303865 C/G cg07080220 chr10:102295463 HIF1AN 0.7 9.3 0.45 1.88e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.37 0.64 1.09e-40 Platelet count; LUSC cis rs9303401 0.659 rs35539277 chr17:56853833 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.85 12.95 0.58 2.27e-31 Cognitive test performance; LUSC cis rs6964587 0.934 rs12531561 chr7:91707780 A/G cg17063962 chr7:91808500 NA 0.59 9.11 0.45 7.8e-18 Breast cancer; LUSC cis rs789294 1 rs789294 chr3:154057741 C/G cg17054900 chr3:154042577 DHX36 0.81 8.69 0.43 1.7e-16 Coronary artery disease; LUSC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 8.07 0.4 1.32e-14 Personality dimensions; LUSC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.31 0.49 8.09e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg06873352 chr17:61820015 STRADA 0.71 12.79 0.57 9.66e-31 Prudent dietary pattern; LUSC trans rs877282 0.838 rs34912955 chr10:772222 T/C cg13042288 chr15:90349979 ANPEP -0.49 -6.82 -0.35 4.39e-11 Uric acid levels; LUSC cis rs26868 0.766 rs30995 chr16:2248017 C/T cg02248941 chr16:2239361 CASKIN1 -0.44 -7.94 -0.4 3.05e-14 Height; LUSC cis rs11030122 0.673 rs10835596 chr11:4099666 C/T cg08557956 chr11:4115526 RRM1 -0.46 -5.96 -0.31 6.57e-9 Mean platelet volume;Platelet distribution width; LUSC trans rs7824557 0.836 rs765731 chr8:11121498 T/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.54 -0.34 2.26e-10 Retinal vascular caliber; LUSC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26801646 chr10:76970496 VDAC2 -0.41 -7.17 -0.37 4.95e-12 Electrocardiographic conduction measures; LUSC cis rs7512552 0.809 rs9436108 chr1:150360930 A/G cg15654264 chr1:150340011 RPRD2 0.61 10.09 0.48 4.38e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs17102423 0.594 rs1957948 chr14:65542629 A/G cg11161011 chr14:65562177 MAX 0.7 10.98 0.51 3.87e-24 Obesity-related traits; LUSC cis rs2486288 0.656 rs62026703 chr15:45569929 G/T cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.42e-10 Glomerular filtration rate; LUSC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2282802 0.660 rs4463213 chr5:139545748 G/A cg26211634 chr5:139558579 C5orf32 -0.41 -7.59 -0.38 3.12e-13 Intelligence (multi-trait analysis); LUSC trans rs2797160 0.651 rs1268067 chr6:126036621 T/C cg05039488 chr6:79577232 IRAK1BP1 0.65 10.16 0.49 2.58e-21 Endometrial cancer; LUSC cis rs929354 0.709 rs1182363 chr7:157019151 A/G cg05182265 chr7:156933206 UBE3C 0.59 9.48 0.46 4.74e-19 Body mass index; LUSC trans rs6502050 0.799 rs34795957 chr17:80118013 G/A cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs8060686 0.641 rs2107369 chr16:68116018 A/C cg04539111 chr16:67997858 SLC12A4 -0.42 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg08209724 chr17:30677138 MIR632;ZNF207 0.4 7.06 0.36 9.58e-12 Triglycerides; LUSC cis rs9807989 0.839 rs10192036 chr2:102968211 C/A cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg26304593 chr6:42947056 PEX6 -0.54 -8.56 -0.42 4.07e-16 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs3857536 0.813 rs9363554 chr6:66930183 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.23 -0.32 1.4e-9 Blood trace element (Cu levels); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03438904 chr3:197518158 LRCH3 -0.44 -6.53 -0.34 2.43e-10 Electrocardiographic conduction measures; LUSC cis rs7089973 0.584 rs6585300 chr10:116639889 A/C cg25233709 chr10:116636983 FAM160B1 0.44 7.83 0.39 6.41e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg12011299 chr4:100065546 ADH4 0.72 10.69 0.5 4.02e-23 Smoking initiation; LUSC trans rs890100 0.902 rs13422571 chr2:56740231 C/T cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.31 -6.09 -0.32 3.15e-9 Gut microbiome composition (summer); LUSC trans rs6502050 0.604 rs9897355 chr17:80078095 G/A cg07393940 chr7:158741817 NA -0.37 -6.76 -0.35 6.27e-11 Life satisfaction; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04048411 chr12:94541943 PLXNC1 -0.49 -6.42 -0.33 4.78e-10 Bipolar disorder and schizophrenia; LUSC cis rs997295 0.618 rs3784698 chr15:68007582 G/C cg05925327 chr15:68127851 NA 0.41 6.48 0.33 3.28e-10 Motion sickness; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg10862848 chr6:42927986 GNMT -0.28 -6.57 -0.34 1.97e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7605827 0.930 rs2049719 chr2:15515058 A/G cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.71e-17 Educational attainment (years of education); LUSC trans rs8002861 0.967 rs7999434 chr13:44482961 T/C cg12856521 chr11:46389249 DGKZ 0.41 6.38 0.33 6.02e-10 Leprosy; LUSC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.37 -0.42 1.66e-15 Height; LUSC cis rs941408 0.515 rs2110118 chr19:2775144 T/C cg02580895 chr19:2754563 NA -0.46 -6.97 -0.36 1.67e-11 Total cholesterol levels; LUSC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg05868516 chr6:26286170 HIST1H4H 0.37 6.09 0.32 3.03e-9 Educational attainment; LUSC cis rs79349575 0.783 rs4793998 chr17:47019899 C/T cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09909775 chr12:45610071 ANO6;PLEKHA9 0.46 5.96 0.31 6.4e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs62408225 1.000 rs62408225 chr6:90956409 A/G cg06866423 chr6:90926672 BACH2 0.4 5.83 0.3 1.33e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.62 0.47 1.7e-19 Personality dimensions; LUSC cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg12935359 chr14:103987150 CKB 0.66 10.45 0.5 2.64e-22 Intelligence (multi-trait analysis); LUSC cis rs7315438 0.758 rs3858648 chr12:115894913 C/A cg24172291 chr12:115889509 NA -0.34 -5.7 -0.3 2.59e-8 Colorectal cancer; LUSC cis rs6940638 0.688 rs9393791 chr6:27132529 C/G cg12292205 chr6:26970375 C6orf41 -0.42 -6.29 -0.33 1.02e-9 Intelligence (multi-trait analysis); LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg00166722 chr3:10149974 C3orf24 0.63 8.47 0.42 7.65e-16 Alzheimer's disease; LUSC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg04719120 chr6:96025338 MANEA 0.48 5.93 0.31 7.59e-9 Behavioural disinhibition (generation interaction); LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg02951883 chr7:2050386 MAD1L1 -0.38 -6.56 -0.34 2.01e-10 Bipolar disorder and schizophrenia; LUSC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg24675056 chr1:15929824 NA 0.48 8.27 0.41 3.15e-15 Systolic blood pressure; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09379601 chr19:12992224 DNASE2 0.49 7.23 0.37 3.28e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg10172584 chr19:19639581 YJEFN3 -0.46 -5.65 -0.3 3.42e-8 Bipolar disorder; LUSC cis rs11190604 0.945 rs11190553 chr10:102207959 T/C cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg21724239 chr8:58056113 NA 0.56 6.8 0.35 4.94e-11 Developmental language disorder (linguistic errors); LUSC cis rs7223966 1.000 rs113134232 chr17:61715461 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.8 0.35 4.73e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7605827 0.930 rs2287274 chr2:15658577 T/C cg19274914 chr2:15703543 NA 0.45 8.69 0.43 1.69e-16 Educational attainment (years of education); LUSC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg14829155 chr15:31115871 NA -0.53 -7.67 -0.39 1.85e-13 Huntington's disease progression; LUSC cis rs500891 0.533 rs583637 chr6:84196263 G/T cg08257003 chr6:84140564 ME1 -0.34 -8.35 -0.42 1.87e-15 Platelet-derived growth factor BB levels; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.25 0.52 4.02e-25 Prudent dietary pattern; LUSC trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.86 -0.35 3.26e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2046867 0.862 rs75638790 chr3:72830502 C/T cg25664220 chr3:72788482 NA -0.71 -11.88 -0.55 2.09e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg09021430 chr5:549028 NA -0.57 -8.63 -0.43 2.6e-16 Ulcerative colitis; LUSC trans rs8181588 1.000 rs2074197 chr11:2825279 C/T cg23136573 chr6:52230573 PAQR8 0.74 5.97 0.31 5.95e-9 Type 2 diabetes; LUSC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.85 -0.63 1.22e-38 Total body bone mineral density; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg05665937 chr4:1216051 CTBP1 0.38 6.01 0.31 4.74e-9 Obesity-related traits; LUSC cis rs708547 0.957 rs2458552 chr4:57773442 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -5.69 -0.3 2.83e-8 Response to bleomycin (chromatid breaks); LUSC cis rs9902453 0.817 rs12941382 chr17:28410124 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.65 -0.5 5.42e-23 Coffee consumption (cups per day); LUSC cis rs11153306 0.552 rs12196381 chr6:111939400 A/C cg22127309 chr6:111907043 TRAF3IP2 0.36 7.16 0.36 5.3e-12 Tonsillectomy; LUSC cis rs4474465 0.850 rs4945287 chr11:78226521 C/T cg27205649 chr11:78285834 NARS2 0.54 6.27 0.32 1.13e-9 Alzheimer's disease (survival time); LUSC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC cis rs9467773 0.587 rs9467722 chr6:26352566 T/C cg05738196 chr6:26577821 NA -0.5 -7.68 -0.39 1.82e-13 Intelligence (multi-trait analysis); LUSC cis rs2073300 1.000 rs6137984 chr20:23469864 T/A cg09953122 chr20:23471693 CST8 -0.87 -6.99 -0.36 1.54e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg21433313 chr16:3507492 NAT15 0.39 6.23 0.32 1.42e-9 Body mass index (adult); LUSC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg26924012 chr15:45694286 SPATA5L1 1.14 21.1 0.76 2.08e-63 Homoarginine levels; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg15365588 chr7:7681016 RPA3 0.36 6.14 0.32 2.35e-9 Schizophrenia; LUSC cis rs11992162 0.551 rs59191504 chr8:11785081 A/G cg21775007 chr8:11205619 TDH -0.43 -6.03 -0.31 4.36e-9 Monocyte count; LUSC cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg10172584 chr19:19639581 YJEFN3 -0.5 -5.99 -0.31 5.3e-9 Bipolar disorder; LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg22638593 chr5:131593259 PDLIM4 0.41 5.95 0.31 6.73e-9 Breast cancer; LUSC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg03433033 chr1:76189801 ACADM 0.76 13.62 0.6 6.8e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg22823121 chr1:150693482 HORMAD1 0.45 6.47 0.33 3.47e-10 Melanoma; LUSC cis rs2806561 0.929 rs6660880 chr1:23540302 T/C cg19743168 chr1:23544995 NA -0.45 -9.74 -0.47 6.75e-20 Height; LUSC cis rs9649213 0.614 rs9640655 chr7:98017099 G/A cg08684580 chr7:98029266 BAIAP2L1 0.38 5.8 0.3 1.52e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs3768617 0.782 rs12146099 chr1:182968079 G/A ch.1.3577855R chr1:183094577 LAMC1 0.59 8.49 0.42 6.66e-16 Fuchs's corneal dystrophy; LUSC trans rs9329221 0.662 rs4240645 chr8:10254463 C/G cg15556689 chr8:8085844 FLJ10661 -0.63 -8.76 -0.43 9.86e-17 Neuroticism; LUSC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.08 -0.4 1.17e-14 Type 2 diabetes; LUSC cis rs539096 0.692 rs7549094 chr1:44213178 C/A cg15962314 chr1:44399869 ARTN 0.24 5.73 0.3 2.28e-8 Intelligence (multi-trait analysis); LUSC cis rs9902453 0.689 rs7216948 chr17:28203173 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.33 0.53 2.09e-25 Coffee consumption (cups per day); LUSC cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.13 -0.41 8.71e-15 Chronic sinus infection; LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.62 0.47 1.65e-19 Bipolar disorder; LUSC cis rs8027181 0.804 rs34661924 chr15:72994564 A/G cg25632853 chr15:73088954 NA 0.33 6.73 0.35 7.22e-11 Triglyceride levels; LUSC cis rs1153858 0.832 rs1145078 chr15:45682277 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.12 0.41 9.19e-15 Homoarginine levels; LUSC cis rs72781680 1.000 rs7588286 chr2:24071427 A/G cg08917208 chr2:24149416 ATAD2B 0.87 9.91 0.48 1.88e-20 Lymphocyte counts; LUSC cis rs11098499 0.505 rs75122014 chr4:120362426 G/C cg24375607 chr4:120327624 NA 0.8 11.96 0.55 1.1e-27 Corneal astigmatism; LUSC cis rs11785693 0.862 rs6995565 chr8:4990461 C/T cg26367366 chr8:4980734 NA -0.72 -8.44 -0.42 9.45e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7927592 0.913 rs67605986 chr11:68300955 C/T cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.55e-9 Total body bone mineral density; LUSC cis rs9420 0.961 rs11601320 chr11:57642617 T/C cg02958346 chr11:57425731 CLP1 -0.46 -6.56 -0.34 2.08e-10 Schizophrenia; LUSC cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg11161846 chr1:160990452 F11R -0.31 -5.69 -0.3 2.8e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg26695010 chr11:65641043 EFEMP2 0.42 6.01 0.31 4.9e-9 Breast cancer; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.48 8.32 0.41 2.3e-15 Prudent dietary pattern; LUSC cis rs2324229 0.828 rs1180203 chr6:83957225 A/G cg08257003 chr6:84140564 ME1 0.29 6.75 0.35 6.5e-11 Platelet-derived growth factor BB levels; LUSC trans rs17685 0.712 rs2158867 chr7:75815141 C/A cg19862616 chr7:65841803 NCRNA00174 1.08 17.88 0.7 1.23e-50 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6494488 0.500 rs72743002 chr15:65011195 G/A cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs10751667 0.643 rs11246362 chr11:969818 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.4 0.33 5.39e-10 Alzheimer's disease (late onset); LUSC cis rs4363385 0.818 rs572821 chr1:153008276 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC trans rs1994135 0.715 rs10844625 chr12:33693006 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.56 0.34 2.1e-10 Resting heart rate; LUSC cis rs8078723 0.714 rs8070444 chr17:38151960 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.4 0.38 1.08e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs611744 0.647 rs2859813 chr8:109263497 G/A cg18478394 chr8:109455254 TTC35 0.44 6.81 0.35 4.63e-11 Dupuytren's disease; LUSC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg25258033 chr6:167368657 RNASET2 -0.49 -8.09 -0.4 1.13e-14 Crohn's disease; LUSC cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC cis rs9902453 1.000 rs8065059 chr17:28417376 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.56 -8.46 -0.42 8.76e-16 Coffee consumption (cups per day); LUSC trans rs7615952 0.546 rs2979333 chr3:125360343 T/A cg07211511 chr3:129823064 LOC729375 -0.53 -6.1 -0.32 2.86e-9 Blood pressure (smoking interaction); LUSC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg14895029 chr7:2775587 GNA12 -0.38 -5.97 -0.31 6.06e-9 Height; LUSC cis rs950169 0.922 rs11630760 chr15:85113337 G/T cg11189052 chr15:85197271 WDR73 0.47 5.81 0.3 1.44e-8 Schizophrenia; LUSC cis rs60015123 0.850 rs73264674 chr12:7131014 C/T cg26269324 chr12:6977084 TPI1 0.77 5.93 0.31 7.39e-9 Red cell distribution width; LUSC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg12963246 chr6:28129442 ZNF389 0.38 5.84 0.3 1.21e-8 Cardiac Troponin-T levels; LUSC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg17366294 chr4:99064904 C4orf37 0.58 10.46 0.5 2.44e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs11122272 0.735 rs2474633 chr1:231486989 A/C cg06096015 chr1:231504339 EGLN1 0.56 9.86 0.47 2.61e-20 Hemoglobin concentration; LUSC cis rs7223966 1.000 rs28463311 chr17:61919643 C/T cg05941027 chr17:61774174 LIMD2 0.22 5.69 0.3 2.75e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs7107174 1.000 rs2511182 chr11:77982130 G/C cg02023728 chr11:77925099 USP35 0.46 6.56 0.34 2.03e-10 Testicular germ cell tumor; LUSC cis rs9457247 0.934 rs2345571 chr6:167403400 T/G cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs9487051 0.702 rs368467 chr6:109519451 T/C cg01475377 chr6:109611718 NA -0.36 -6.11 -0.32 2.7e-9 Reticulocyte fraction of red cells; LUSC cis rs1865760 0.963 rs3846838 chr6:25911775 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.87 0.35 3.11e-11 Height; LUSC trans rs6502050 0.835 rs34960918 chr17:80113925 A/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs1044826 0.642 rs7624321 chr3:139220159 C/A cg15131784 chr3:139108705 COPB2 0.39 6.34 0.33 7.33e-10 Obesity-related traits; LUSC trans rs634534 0.622 rs624273 chr11:65712413 A/G cg17712092 chr4:129076599 LARP1B 0.74 10.99 0.52 3.53e-24 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg11764359 chr7:65958608 NA 0.54 6.97 0.36 1.75e-11 Aortic root size; LUSC cis rs2267137 0.747 rs1963292 chr22:29805867 T/C cg07256473 chr22:29710276 RASL10A 0.38 7.33 0.37 1.75e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs12579753 0.872 rs12319937 chr12:82182545 T/G cg21231944 chr12:82153410 PPFIA2 -0.37 -5.7 -0.3 2.63e-8 Resting heart rate; LUSC cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.63 0.85 1.69e-95 Chronic sinus infection; LUSC cis rs62400317 0.859 rs10948213 chr6:45158515 T/C cg18551225 chr6:44695536 NA -0.45 -7.22 -0.37 3.47e-12 Total body bone mineral density; LUSC cis rs4595586 0.566 rs11615585 chr12:39409351 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.16e-12 Morning vs. evening chronotype; LUSC cis rs6964587 0.869 rs4729010 chr7:91486751 G/A cg17063962 chr7:91808500 NA -0.52 -8.06 -0.4 1.34e-14 Breast cancer; LUSC cis rs868036 0.645 rs4776972 chr15:68083436 A/C cg08079166 chr15:68083412 MAP2K5 0.49 8.12 0.41 8.9e-15 Restless legs syndrome; LUSC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg16928487 chr17:17741425 SREBF1 0.37 7.13 0.36 6.28e-12 Total body bone mineral density; LUSC cis rs61990749 0.597 rs13379065 chr14:78141295 C/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.41 -0.33 4.99e-10 Fibroblast growth factor basic levels; LUSC cis rs7512552 0.809 rs1694377 chr1:150293153 A/G cg15654264 chr1:150340011 RPRD2 0.66 11.15 0.52 9.34e-25 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9479482 1.000 rs5006620 chr6:150336665 C/T cg03788504 chr6:150331562 NA -0.27 -6.01 -0.31 4.88e-9 Alopecia areata; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg07703079 chr11:430292 ANO9 0.64 6.7 0.34 8.87e-11 Body mass index; LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg13560548 chr3:10150139 C3orf24 0.51 7.22 0.37 3.61e-12 Alzheimer's disease; LUSC cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.59 8.3 0.41 2.62e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09184467 chr10:14995699 DCLRE1C -0.38 -6.28 -0.32 1.03e-9 Electrocardiographic conduction measures; LUSC trans rs4927850 1.000 rs7614767 chr3:195753451 C/T cg16724585 chr3:197361211 NA -0.59 -8.51 -0.42 6.03e-16 Pancreatic cancer; LUSC cis rs7100689 0.646 rs1538819 chr10:82122523 A/G cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs7474896 0.537 rs2472149 chr10:38262196 A/C cg25427524 chr10:38739819 LOC399744 0.45 5.95 0.31 6.81e-9 Obesity (extreme); LUSC cis rs11122272 0.735 rs2790881 chr1:231534181 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.11 -0.48 3.98e-21 Hemoglobin concentration; LUSC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.71 7.16 0.36 5.14e-12 Initial pursuit acceleration; LUSC cis rs912057 0.671 rs1294433 chr6:6745163 G/A cg06612196 chr6:6737390 NA 0.55 10.78 0.51 1.91e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg03929089 chr4:120376271 NA 0.69 7.79 0.39 8.71e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg18132916 chr6:79620363 NA -0.4 -6.08 -0.32 3.29e-9 Intelligence (multi-trait analysis); LUSC cis rs7953249 0.514 rs1169312 chr12:121441461 G/T cg02403541 chr12:121454288 C12orf43 0.59 8.45 0.42 8.98e-16 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg11494091 chr17:61959527 GH2 0.65 13.75 0.6 2.03e-34 Prudent dietary pattern; LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6598955 0.670 rs3795685 chr1:26601385 A/G cg00852783 chr1:26633632 UBXN11 -0.49 -8.76 -0.43 1.02e-16 Obesity-related traits; LUSC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg00784671 chr22:46762841 CELSR1 -0.54 -6.79 -0.35 5.18e-11 LDL cholesterol;Cholesterol, total; LUSC trans rs35110281 0.720 rs162375 chr21:44927015 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.62 -10.91 -0.51 6.48e-24 Mean corpuscular volume; LUSC cis rs3820068 0.603 rs7516453 chr1:15972558 C/G cg13390004 chr1:15929781 NA 0.41 6.54 0.34 2.28e-10 Systolic blood pressure; LUSC cis rs7202877 0.706 rs1540 chr16:75481185 G/C cg03315344 chr16:75512273 CHST6 -0.45 -6.22 -0.32 1.48e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg26408565 chr15:76604113 ETFA -0.36 -5.64 -0.3 3.53e-8 Blood metabolite levels; LUSC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg16989086 chr20:62203971 PRIC285 0.46 6.42 0.33 4.69e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg04362960 chr10:104952993 NT5C2 0.57 8.83 0.44 5.99e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs72781680 0.768 rs112139157 chr2:24150783 A/C cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.8 0.47 4.17e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg06808227 chr14:105710500 BRF1 -0.66 -9.9 -0.48 1.9e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.94 0.48 1.47e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2502731 0.539 rs3003608 chr9:130984430 C/A cg09976142 chr9:130955436 CIZ1 0.39 6.52 0.34 2.65e-10 Attention deficit hyperactivity disorder; LUSC cis rs4891159 0.548 rs690423 chr18:74117984 G/A cg24786174 chr18:74118243 ZNF516 0.97 21.42 0.76 1.16e-64 Longevity; LUSC cis rs2635047 0.967 rs2571001 chr18:44665083 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.83 0.35 4.02e-11 Educational attainment; LUSC trans rs72674100 1.000 rs28612505 chr4:97992338 G/T cg09670535 chr1:18959427 PAX7 -0.63 -6.52 -0.34 2.63e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3849570 0.555 rs4452351 chr3:82007977 C/T cg07356753 chr3:81810745 GBE1 -0.42 -6.04 -0.31 4.12e-9 Waist circumference;Body mass index; LUSC cis rs1997103 1.000 rs6593233 chr7:55406200 C/T cg17469321 chr7:55412551 NA -0.67 -10.79 -0.51 1.73e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs477692 0.629 rs945231 chr10:131294827 A/G cg26102564 chr10:131424627 MGMT 0.41 6.38 0.33 5.9e-10 Response to temozolomide; LUSC cis rs892961 1.000 rs1075457 chr17:75400737 A/G cg05865280 chr17:75406074 SEPT9 -0.45 -9.9 -0.48 1.91e-20 Airflow obstruction; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg27524515 chr8:38239417 WHSC1L1 -0.53 -7.21 -0.37 3.85e-12 Cognitive function;Information processing speed; LUSC cis rs11785400 0.793 rs34875149 chr8:143736131 G/A cg10596483 chr8:143751796 JRK 0.53 7.66 0.39 1.98e-13 Schizophrenia; LUSC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg21724239 chr8:58056113 NA 0.57 6.58 0.34 1.87e-10 Developmental language disorder (linguistic errors); LUSC cis rs17818399 0.501 rs13413254 chr2:46802934 A/T cg26688816 chr2:46740690 ATP6V1E2 -0.46 -6.93 -0.35 2.14e-11 Height; LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg05368731 chr17:41323189 NBR1 0.93 15.69 0.65 5.75e-42 Menopause (age at onset); LUSC trans rs2204008 0.775 rs11514369 chr12:38305411 C/T cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Bladder cancer; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg16393715 chr7:1948819 MAD1L1 0.39 6.75 0.35 6.43e-11 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.99 -0.31 5.52e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg07700843 chr1:2391317 NA -0.44 -6.81 -0.35 4.43e-11 Non-obstructive azoospermia; LUSC cis rs10911251 0.528 rs4652777 chr1:183091992 T/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.94 0.51 4.97e-24 Colorectal cancer; LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.52 0.59 1.57e-33 Platelet count; LUSC cis rs593982 0.920 rs563427 chr11:65484569 A/G cg08755490 chr11:65554678 OVOL1 1.51 13.45 0.59 3.1e-33 Atopic dermatitis; LUSC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg14019146 chr3:50243930 SLC38A3 -0.32 -7.21 -0.37 3.74e-12 Intelligence (multi-trait analysis); LUSC cis rs12541635 0.966 rs4734894 chr8:106995313 G/A cg10147462 chr8:107024639 NA 0.55 9.77 0.47 5.52e-20 Age of smoking initiation; LUSC cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg03146154 chr1:46216737 IPP -0.51 -7.36 -0.37 1.47e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2070488 0.761 rs6807940 chr3:38460062 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.65 11.21 0.52 5.73e-25 Electrocardiographic conduction measures; LUSC cis rs204247 0.565 rs411094 chr6:13718264 C/A cg02206980 chr6:13574034 SIRT5 -0.43 -8.73 -0.43 1.21e-16 Breast cancer; LUSC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 9.15 0.45 5.96e-18 Hip circumference adjusted for BMI; LUSC cis rs977987 0.778 rs35415181 chr16:75403124 T/C cg03315344 chr16:75512273 CHST6 0.49 9.33 0.45 1.48e-18 Dupuytren's disease; LUSC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg01448562 chr3:133502909 NA -0.77 -13.41 -0.59 4.15e-33 Iron status biomarkers; LUSC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg14552801 chr7:65878734 NA 0.45 6.34 0.33 7.34e-10 Aortic root size; LUSC cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 7.88 0.4 4.73e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs12220238 1.000 rs11000930 chr10:75982982 C/G cg19889307 chr10:75911429 ADK;AP3M1 -0.64 -6.75 -0.35 6.57e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs193541 0.632 rs39821 chr5:122295472 T/C cg19077854 chr5:122220652 SNX24 0.39 8.38 0.42 1.48e-15 Glucose homeostasis traits; LUSC cis rs713477 0.845 rs4898863 chr14:55910284 T/A cg13175173 chr14:55914753 NA -0.3 -6.19 -0.32 1.76e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs10740039 0.516 rs2893840 chr10:62314015 T/C cg18175470 chr10:62150864 ANK3 -0.47 -6.91 -0.35 2.44e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.79 10.06 0.48 5.75e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2274459 0.841 rs2281919 chr6:33663171 A/C cg06253072 chr6:33679850 C6orf125 0.48 5.76 0.3 1.94e-8 Obesity (extreme); LUSC cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg02228329 chr11:64053129 BAD;GPR137 0.44 6.21 0.32 1.59e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs11971779 1.000 rs11971779 chr7:139040258 A/G cg07862535 chr7:139043722 LUC7L2 -0.71 -8.09 -0.4 1.1e-14 Diisocyanate-induced asthma; LUSC cis rs9303401 0.659 rs12944971 chr17:56988801 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.85 12.88 0.58 4.26e-31 Cognitive test performance; LUSC trans rs11039798 0.844 rs7126949 chr11:48972166 A/G cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs12579753 0.917 rs11115029 chr12:82202219 C/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs9687065 1.000 rs10078963 chr5:148400424 G/A cg23229984 chr5:148520753 ABLIM3 -0.38 -5.67 -0.3 3.16e-8 Diastolic blood pressure; LUSC cis rs12421382 0.659 rs1371330 chr11:109382692 G/T cg27471124 chr11:109292789 C11orf87 0.41 7.22 0.37 3.44e-12 Schizophrenia; LUSC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg20933634 chr6:27740509 NA 0.43 5.93 0.31 7.46e-9 Parkinson's disease; LUSC cis rs11098499 0.779 rs7699346 chr4:120310542 C/T cg09307838 chr4:120376055 NA 0.79 11.49 0.53 5.74e-26 Corneal astigmatism; LUSC cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.78 0.72 3.31e-54 Chronic sinus infection; LUSC cis rs4474465 0.790 rs10751295 chr11:78266047 T/A cg27205649 chr11:78285834 NARS2 0.51 6.05 0.31 3.99e-9 Alzheimer's disease (survival time); LUSC cis rs757278 0.591 rs1042180 chr7:117308413 C/T cg10524701 chr7:117356490 CTTNBP2 0.4 5.76 0.3 1.9e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs2692947 0.550 rs12623771 chr2:96633504 A/G cg22654517 chr2:96458247 NA 0.34 6.87 0.35 3.23e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7246657 0.941 rs7259618 chr19:37750719 G/A cg23950597 chr19:37808831 NA -0.61 -6.99 -0.36 1.53e-11 Coronary artery calcification; LUSC cis rs4450131 0.522 rs11245327 chr10:126358174 T/C cg20435097 chr10:126320824 FAM53B 0.24 6.25 0.32 1.27e-9 White blood cell count (basophil); LUSC cis rs9640161 0.830 rs11768108 chr7:150064150 C/T cg17279839 chr7:150038598 RARRES2 0.4 6.15 0.32 2.2e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg12751644 chr20:60527061 NA -0.32 -5.78 -0.3 1.74e-8 Body mass index; LUSC cis rs2836633 0.929 rs4143428 chr21:40030582 G/T cg12884169 chr21:40033163 ERG 0.61 12.27 0.56 7.69e-29 Coronary artery disease; LUSC cis rs17092148 1.000 rs910871 chr20:33333208 C/A cg16810054 chr20:33298113 TP53INP2 -0.41 -6.42 -0.33 4.77e-10 Neuroticism; LUSC cis rs7267979 0.933 rs2258728 chr20:25276343 G/A cg03522245 chr20:25566470 NINL 0.35 5.68 0.3 2.99e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs877282 0.945 rs11253397 chr10:789774 A/G cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.86 0.4 5.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg19418458 chr7:158789849 NA -0.57 -9.13 -0.45 6.68e-18 Facial morphology (factor 20); LUSC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg08270630 chr22:50330655 NA 0.41 6.09 0.32 3.03e-9 Schizophrenia; LUSC cis rs9300255 0.544 rs10772995 chr12:123671761 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.12 -0.32 2.66e-9 Neutrophil percentage of white cells; LUSC cis rs2692947 0.637 rs72492201 chr2:96630201 G/A cg22654517 chr2:96458247 NA 0.32 6.22 0.32 1.52e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2075371 0.501 rs1646652 chr7:134024515 A/T cg20476274 chr7:133979776 SLC35B4 0.7 12.0 0.55 7.87e-28 Mean platelet volume; LUSC cis rs1113500 0.933 rs745795 chr1:108629345 C/T cg06207961 chr1:108661230 NA 0.4 7.45 0.38 8.2e-13 Growth-regulated protein alpha levels; LUSC cis rs1451375 0.959 rs6962356 chr7:50621941 T/C cg18232548 chr7:50535776 DDC 0.51 7.84 0.39 6.19e-14 Malaria; LUSC cis rs6494488 0.500 rs72744740 chr15:65050491 C/G cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC trans rs7939886 0.920 rs74962317 chr11:56036589 C/T cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.05 21.75 0.77 5.93e-66 Height; LUSC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg23711669 chr6:146136114 FBXO30 0.88 16.13 0.66 1.12e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.9 0.31 8.88e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.15 25.2 0.81 2.88e-79 Chronic sinus infection; LUSC cis rs4964805 0.594 rs4964830 chr12:104168908 A/G cg02344784 chr12:104178138 NT5DC3 -0.36 -5.73 -0.3 2.21e-8 Attention deficit hyperactivity disorder; LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg25767906 chr1:53392781 SCP2 -0.65 -12.85 -0.58 5.69e-31 Monocyte count; LUSC trans rs7786808 0.504 rs10949725 chr7:158196003 C/T cg02030672 chr11:45687055 CHST1 -0.43 -6.85 -0.35 3.46e-11 Obesity-related traits; LUSC trans rs2204008 0.720 rs11180923 chr12:38255172 A/T cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.74e-9 Bladder cancer; LUSC cis rs68170813 0.559 rs1989814 chr7:107045076 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.65 -0.3 3.4e-8 Coronary artery disease; LUSC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg26850624 chr5:429559 AHRR -0.37 -7.04 -0.36 1.08e-11 Cystic fibrosis severity; LUSC cis rs131777 0.547 rs131753 chr22:51022862 A/G cg25309564 chr22:51001381 C22orf41 0.43 6.06 0.31 3.67e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg11211951 chr8:145729740 GPT 0.57 11.13 0.52 1.09e-24 Age at first birth; LUSC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg09640425 chr7:158790006 NA -0.46 -7.08 -0.36 8.43e-12 Facial morphology (factor 20); LUSC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg11245181 chr6:149772854 ZC3H12D -0.33 -7.09 -0.36 7.79e-12 Dupuytren's disease; LUSC cis rs1577917 1.000 rs12215037 chr6:86727631 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.68e-17 Response to antipsychotic treatment; LUSC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg18240062 chr17:79603768 NPLOC4 0.71 13.16 0.58 3.7e-32 Eye color traits; LUSC cis rs208520 0.955 rs9453664 chr6:66976079 A/C cg07460842 chr6:66804631 NA 0.94 12.35 0.56 4.02e-29 Exhaled nitric oxide output; LUSC trans rs11098499 0.863 rs3775841 chr4:120425777 A/C cg25214090 chr10:38739885 LOC399744 0.51 7.43 0.38 9.11e-13 Corneal astigmatism; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg25428297 chr7:1022841 CYP2W1 0.28 5.66 0.3 3.32e-8 Longevity;Endometriosis; LUSC cis rs4595586 0.545 rs17546375 chr12:39407248 C/A cg26384229 chr12:38710491 ALG10B 0.52 7.41 0.38 1.06e-12 Morning vs. evening chronotype; LUSC trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg03929089 chr4:120376271 NA -0.6 -7.24 -0.37 3.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.88e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs34779708 0.966 rs57081218 chr10:35434608 A/G cg04310649 chr10:35416472 CREM -0.41 -6.52 -0.34 2.6e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12900413 0.687 rs12906905 chr15:90315399 A/G cg24249390 chr15:90295951 MESP1 -0.37 -5.75 -0.3 2.05e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg21782813 chr7:2030301 MAD1L1 -0.44 -7.33 -0.37 1.76e-12 Bipolar disorder and schizophrenia; LUSC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg10523679 chr1:76189770 ACADM 0.83 12.78 0.57 9.76e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg27211696 chr2:191398769 TMEM194B -0.61 -11.82 -0.54 3.68e-27 Pulse pressure; LUSC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg16743903 chr16:89593216 SPG7 -0.38 -5.92 -0.31 7.84e-9 Multiple myeloma (IgH translocation); LUSC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg01503450 chr10:980765 NA -0.36 -5.84 -0.3 1.26e-8 Eosinophil percentage of granulocytes; LUSC cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg01884057 chr2:25150051 NA 0.47 10.68 0.5 4.18e-23 Body mass index in non-asthmatics; LUSC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg22968622 chr17:43663579 NA -0.79 -12.21 -0.56 1.33e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg09858108 chr8:58055024 NA 0.52 7.02 0.36 1.24e-11 Developmental language disorder (linguistic errors); LUSC cis rs453301 0.686 rs1045527 chr8:8890041 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.81 -0.39 7.69e-14 Joint mobility (Beighton score); LUSC cis rs11158026 0.576 rs56013432 chr14:55351179 T/C cg04306507 chr14:55594613 LGALS3 0.4 6.43 0.33 4.45e-10 Parkinson's disease; LUSC cis rs2806561 1.000 rs1208932 chr1:23429122 T/G cg19743168 chr1:23544995 NA -0.44 -9.37 -0.46 1.09e-18 Height; LUSC cis rs36093844 1.000 rs36093844 chr11:85576127 A/G cg16165120 chr11:85566439 CCDC83 0.35 5.84 0.3 1.24e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg01416388 chr22:39784598 NA -0.45 -7.03 -0.36 1.13e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.3 0.41 2.67e-15 Prudent dietary pattern; LUSC cis rs9865818 0.545 rs12634152 chr3:188121019 C/T cg23651889 chr3:188115336 LPP 0.38 5.94 0.31 7.11e-9 Allergic sensitization; LUSC cis rs950027 0.620 rs1346267 chr15:45690989 A/G cg21132104 chr15:45694354 SPATA5L1 0.42 6.1 0.32 2.96e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs11785400 1.000 rs4736368 chr8:143748528 G/C cg10596483 chr8:143751796 JRK 0.6 9.28 0.45 2.23e-18 Schizophrenia; LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs61931739 1.000 rs12298806 chr12:34036528 C/G cg13010199 chr12:38710504 ALG10B -0.4 -6.01 -0.31 4.99e-9 Morning vs. evening chronotype; LUSC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.83 0.35 4.01e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg07701084 chr6:150067640 NUP43 0.58 9.19 0.45 4.31e-18 Lung cancer; LUSC cis rs61931739 0.500 rs11053271 chr12:34545407 C/A cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC trans rs1005277 0.541 rs2505193 chr10:38394638 G/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.53 -0.46 3.44e-19 Extrinsic epigenetic age acceleration; LUSC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg24675056 chr1:15929824 NA 0.46 8.02 0.4 1.83e-14 Systolic blood pressure; LUSC cis rs208520 1.000 rs12191403 chr6:66978137 C/T cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs6690583 0.623 rs61768853 chr1:85455707 T/C cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.03e-10 Serum sulfate level; LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11945232 1.000 rs28630962 chr4:88336386 C/T cg23841344 chr4:88312519 HSD17B11 -0.67 -10.15 -0.49 2.86e-21 Intelligence (multi-trait analysis); LUSC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 6.15 0.32 2.21e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07973146 chr20:18488185 SEC23B -0.44 -5.94 -0.31 6.98e-9 Hepatitis; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg24531977 chr5:56204891 C5orf35 -1.17 -18.44 -0.71 7.36e-53 Initial pursuit acceleration; LUSC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg18225595 chr11:63971243 STIP1 0.66 11.27 0.52 3.61e-25 Platelet count; LUSC cis rs2742234 1.000 rs2742234 chr10:43612609 A/G cg02780029 chr10:43622663 RET 0.32 6.14 0.32 2.37e-9 Hirschsprung disease; LUSC trans rs12200782 1.000 rs4515370 chr6:26625319 T/C cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC cis rs2688608 0.592 rs7908825 chr10:75554541 C/G cg23231163 chr10:75533350 FUT11 0.43 7.12 0.36 6.71e-12 Inflammatory bowel disease; LUSC cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.28 -0.37 2.44e-12 Bipolar disorder; LUSC cis rs9399135 0.967 rs1854865 chr6:135360300 C/G cg22676075 chr6:135203613 NA 0.47 7.26 0.37 2.7e-12 Red blood cell count; LUSC cis rs7917772 0.546 rs10883743 chr10:104338389 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1413885 0.504 rs9436287 chr1:65863302 A/G cg14976592 chr1:65886160 LEPROT;LEPR -0.39 -5.78 -0.3 1.71e-8 Anticoagulant levels; LUSC cis rs1670533 1.000 rs4690213 chr4:1054868 C/T cg02018176 chr4:1364513 KIAA1530 0.44 6.05 0.31 3.91e-9 Recombination rate (females); LUSC cis rs9815354 0.680 rs73073239 chr3:42014597 G/C cg03022575 chr3:42003672 ULK4 0.78 7.52 0.38 4.94e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs11190604 0.767 rs74869390 chr10:102189385 A/G cg07080220 chr10:102295463 HIF1AN 0.59 7.86 0.4 5.23e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs921665 0.831 rs6751452 chr2:3183930 T/G cg02624386 chr2:3182749 NA 0.58 6.54 0.34 2.35e-10 World class endurance athleticism; LUSC cis rs548181 0.621 rs2912098 chr11:125528569 C/T cg03464685 chr11:125439445 EI24 1.15 13.9 0.61 5.42e-35 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7589342 0.536 rs10177914 chr2:106386693 G/T cg09152813 chr2:106391379 NCK2 -0.37 -6.07 -0.32 3.43e-9 Addiction; LUSC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.39 -6.15 -0.32 2.25e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs11098499 0.820 rs28535956 chr4:120536858 C/T cg25214090 chr10:38739885 LOC399744 -0.51 -7.52 -0.38 5e-13 Corneal astigmatism; LUSC cis rs4654899 1.000 rs6659152 chr1:21355841 C/G cg01072550 chr1:21505969 NA -0.49 -7.61 -0.38 2.85e-13 Superior frontal gyrus grey matter volume; LUSC cis rs2219968 0.828 rs10808823 chr8:78903013 C/T cg00738934 chr8:78996279 NA -0.38 -6.76 -0.35 6.09e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs814295 0.866 rs74928908 chr2:27744089 A/G cg27432699 chr2:27873401 GPN1 0.5 6.02 0.31 4.55e-9 Triglyceride levels; LUSC cis rs2979489 0.533 rs62505280 chr8:30448124 C/T cg26383811 chr8:30366931 RBPMS -0.45 -7.35 -0.37 1.57e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC trans rs9291683 0.530 rs73227883 chr4:9979279 T/C cg26043149 chr18:55253948 FECH 0.48 7.39 0.37 1.22e-12 Bone mineral density; LUSC cis rs12681288 0.723 rs12545453 chr8:970582 C/T cg04851639 chr8:1020857 NA -0.4 -8.37 -0.42 1.63e-15 Schizophrenia; LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg00149659 chr3:10157352 C3orf10 1.01 14.57 0.62 1.42e-37 Alzheimer's disease; LUSC cis rs4595586 0.505 rs6580897 chr12:39372254 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.03 0.31 4.27e-9 Morning vs. evening chronotype; LUSC cis rs7615316 0.934 rs9808914 chr3:142241058 T/G cg16271453 chr3:142027066 XRN1 -0.4 -6.83 -0.35 3.93e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs877282 0.533 rs10904565 chr10:819991 G/T cg13042288 chr15:90349979 ANPEP -0.42 -6.34 -0.33 7.48e-10 Uric acid levels; LUSC trans rs8073060 0.586 rs226090 chr17:34034059 C/T cg19694781 chr19:47549865 TMEM160 -1.14 -18.04 -0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs12681287 0.570 rs4961188 chr8:87383033 T/C cg27223183 chr8:87520930 FAM82B 0.55 7.37 0.37 1.37e-12 Caudate activity during reward; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg15804432 chr15:64454965 PPIB 0.44 6.34 0.33 7.61e-10 Neuroticism; LUSC trans rs3824488 0.920 rs80155616 chr9:98243868 C/T cg23555120 chr12:106533863 NUAK1 0.57 6.19 0.32 1.81e-9 Neuroticism; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg16606324 chr3:10149918 C3orf24 0.59 8.53 0.42 5.1e-16 Alzheimer's disease; LUSC cis rs6580649 0.783 rs1635526 chr12:48396785 C/T cg24011408 chr12:48396354 COL2A1 0.58 7.66 0.39 1.99e-13 Lung cancer; LUSC trans rs12310956 0.532 rs2171534 chr12:33838998 C/T cg26384229 chr12:38710491 ALG10B 0.53 8.05 0.4 1.46e-14 Morning vs. evening chronotype; LUSC cis rs2708377 0.858 rs55748583 chr12:11139712 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.82 8.01 0.4 1.92e-14 Bitter taste perception; LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg00132208 chr4:10120780 NA 0.35 5.71 0.3 2.49e-8 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8017423 0.967 rs11624725 chr14:90713609 G/T cg04374321 chr14:90722782 PSMC1 -0.71 -11.58 -0.54 2.58e-26 Mortality in heart failure; LUSC cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg00012203 chr2:219082015 ARPC2 0.81 14.2 0.61 3.83e-36 Colorectal cancer; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.51 -7.89 -0.4 4.4e-14 Prudent dietary pattern; LUSC cis rs2197308 0.765 rs7295711 chr12:37903631 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg03188948 chr7:1209495 NA 0.66 7.06 0.36 9.67e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg17143192 chr8:8559678 CLDN23 0.61 8.71 0.43 1.39e-16 Obesity-related traits; LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg18099408 chr3:52552593 STAB1 -0.4 -6.85 -0.35 3.62e-11 Bipolar disorder; LUSC cis rs10746514 0.768 rs11122427 chr1:232261085 C/T cg09506761 chr1:232265262 NA -0.56 -9.56 -0.46 2.57e-19 Response to statin therapy; LUSC cis rs6546550 0.868 rs12713682 chr2:70154134 G/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.31 -0.37 2.02e-12 Prevalent atrial fibrillation; LUSC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg00033643 chr7:134001901 SLC35B4 0.47 7.35 0.37 1.53e-12 Mean platelet volume; LUSC cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg14530993 chr4:882597 GAK 0.73 7.48 0.38 6.78e-13 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg04369109 chr6:150039330 LATS1 -0.57 -8.36 -0.42 1.68e-15 Lung cancer; LUSC cis rs894344 0.650 rs56411737 chr8:135582243 C/T cg17885191 chr8:135476712 NA 0.4 5.65 0.3 3.45e-8 Systolic blood pressure; LUSC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg04369109 chr6:150039330 LATS1 -0.58 -8.43 -0.42 1.02e-15 Lung cancer; LUSC cis rs4343996 0.967 rs10228723 chr7:3348120 A/G cg21248987 chr7:3385318 SDK1 0.4 6.66 0.34 1.1e-10 Motion sickness; LUSC cis rs2286503 0.839 rs2270107 chr7:22862183 G/A cg11367502 chr7:22862612 TOMM7 0.46 6.22 0.32 1.51e-9 Fibrinogen; LUSC cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg03146154 chr1:46216737 IPP -0.51 -7.73 -0.39 1.3e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1559088 0.625 rs10411739 chr19:33616327 T/C cg17764715 chr19:33622953 WDR88 0.57 8.36 0.42 1.74e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg07701084 chr6:150067640 NUP43 -0.5 -7.44 -0.38 8.38e-13 Lung cancer; LUSC cis rs75804782 0.641 rs56396448 chr2:239335234 C/T cg18131467 chr2:239335373 ASB1 -0.74 -6.62 -0.34 1.45e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs17253792 0.908 rs9972177 chr14:56073206 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.9e-12 Putamen volume; LUSC cis rs8044995 0.563 rs61602448 chr16:68377520 C/T cg09835421 chr16:68378352 PRMT7 -0.76 -8.49 -0.42 7.06e-16 Schizophrenia; LUSC cis rs8017423 0.935 rs12884698 chr14:90750566 G/A cg04374321 chr14:90722782 PSMC1 -0.68 -10.35 -0.49 5.96e-22 Mortality in heart failure; LUSC cis rs2559856 1.000 rs2559855 chr12:102090080 A/G cg24337881 chr12:102091387 CHPT1 -0.43 -6.29 -0.33 9.74e-10 Blood protein levels; LUSC cis rs7804356 1.000 rs3823931 chr7:26854026 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg27211696 chr2:191398769 TMEM194B 0.6 11.62 0.54 1.88e-26 Pulse pressure; LUSC cis rs11098499 0.909 rs10014719 chr4:120320715 G/A cg24375607 chr4:120327624 NA 0.78 11.51 0.53 4.8e-26 Corneal astigmatism; LUSC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg17252645 chr8:143867129 LY6D 0.38 6.74 0.35 6.83e-11 Urinary tract infection frequency; LUSC cis rs8177253 0.555 rs4481157 chr3:133464684 G/A cg08048268 chr3:133502702 NA -0.33 -6.25 -0.32 1.23e-9 Iron status biomarkers; LUSC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg17376030 chr22:41985996 PMM1 0.47 5.91 0.31 8.36e-9 Vitiligo; LUSC cis rs2798269 0.668 rs1199950 chr13:22091153 A/G cg18095732 chr13:22033692 ZDHHC20 -0.38 -5.97 -0.31 5.96e-9 PR segment; LUSC cis rs13242816 1.000 rs56298491 chr7:116116687 C/T cg16553024 chr7:116138462 CAV2 -0.52 -5.72 -0.3 2.37e-8 P wave duration; LUSC cis rs6940638 0.688 rs7744759 chr6:27119826 G/A cg09904177 chr6:26538194 HMGN4 -0.47 -6.88 -0.35 2.99e-11 Intelligence (multi-trait analysis); LUSC cis rs9420 0.961 rs527528 chr11:57433327 C/T cg02958346 chr11:57425731 CLP1 -0.39 -5.71 -0.3 2.47e-8 Schizophrenia; LUSC cis rs9616064 0.889 rs7284276 chr22:46996137 G/C cg05621596 chr22:47072043 GRAMD4 -0.44 -6.63 -0.34 1.33e-10 Urate levels in obese individuals; LUSC cis rs36096196 0.891 rs12082516 chr1:2251160 C/T cg17974515 chr1:2252516 NA -0.39 -7.45 -0.38 8.15e-13 Coronary artery disease; LUSC cis rs6542838 0.641 rs13005124 chr2:99527680 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.56 -7.58 -0.38 3.46e-13 Fear of minor pain; LUSC cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg07606381 chr6:8435919 SLC35B3 0.73 12.47 0.56 1.48e-29 Motion sickness; LUSC cis rs7084921 0.521 rs12782269 chr10:101875210 T/C cg02250046 chr10:101825185 CPN1 -0.31 -5.89 -0.31 9.4e-9 Bone mineral density; LUSC cis rs9581857 1.000 rs9581857 chr13:28027714 A/C cg22138327 chr13:27999177 GTF3A 0.8 9.06 0.44 1.08e-17 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg05872129 chr22:39784769 NA -0.51 -8.26 -0.41 3.37e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11603020 0.950 rs28362951 chr11:57372526 A/G cg23127183 chr11:57508653 C11orf31 -0.45 -6.28 -0.32 1.08e-9 Blood protein levels; LUSC cis rs11031096 0.536 rs894459 chr11:4213590 A/G cg08557956 chr11:4115526 RRM1 -0.42 -5.72 -0.3 2.37e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9403521 1.000 rs12208927 chr6:143993634 A/G cg18240653 chr6:144019428 PHACTR2 -0.48 -5.84 -0.3 1.25e-8 Obesity-related traits; LUSC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg25036284 chr2:26402008 FAM59B -0.68 -9.47 -0.46 5.29e-19 Gut microbiome composition (summer); LUSC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 6.97e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg11584989 chr19:19387371 SF4 0.58 7.02 0.36 1.22e-11 Bipolar disorder; LUSC cis rs782590 0.643 rs13009906 chr2:55739434 A/G cg18811423 chr2:55921094 PNPT1 -0.65 -9.55 -0.46 2.8e-19 Metabolic syndrome; LUSC cis rs4555082 0.957 rs8022526 chr14:105756485 A/G cg27165867 chr14:105738592 BRF1 -0.53 -7.68 -0.39 1.79e-13 Mean platelet volume;Platelet distribution width; LUSC trans rs7170930 0.618 rs67243507 chr15:66547088 C/T cg06396762 chr16:3202609 NA -0.72 -5.98 -0.31 5.75e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg08213375 chr14:104286397 PPP1R13B 0.52 10.24 0.49 1.38e-21 Schizophrenia; LUSC cis rs921968 0.643 rs596076 chr2:219451015 T/G cg02176678 chr2:219576539 TTLL4 0.61 10.95 0.51 4.76e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs147144681 1 rs147144681 chr15:78900908 C/T cg06917634 chr15:78832804 PSMA4 -0.44 -5.98 -0.31 5.8e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.49 8.97 0.44 2.24e-17 Total body bone mineral density; LUSC cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg13256891 chr4:100009986 ADH5 0.51 7.03 0.36 1.21e-11 Smoking initiation; LUSC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg26597838 chr10:835615 NA 0.99 13.85 0.6 9.05e-35 Eosinophil percentage of granulocytes; LUSC trans rs800082 0.507 rs2575183 chr3:144260523 C/T cg24215973 chr2:240111563 HDAC4 0.48 7.48 0.38 6.74e-13 Smoking behavior; LUSC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -8.71 -0.43 1.45e-16 Hemoglobin concentration; LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg22638593 chr5:131593259 PDLIM4 0.49 7.48 0.38 6.76e-13 Acylcarnitine levels; LUSC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg03188948 chr7:1209495 NA 0.46 6.07 0.32 3.41e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg05082376 chr22:42548792 NA -0.43 -6.53 -0.34 2.43e-10 Schizophrenia; LUSC cis rs1419980 0.630 rs2377089 chr12:7737325 T/C cg25828445 chr12:7781288 NA 0.57 5.97 0.31 5.96e-9 HDL cholesterol levels; LUSC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg16049864 chr8:95962084 TP53INP1 -0.66 -12.3 -0.56 6.3e-29 Type 2 diabetes; LUSC cis rs7267979 1.000 rs4815421 chr20:25386509 G/A cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7615952 0.741 rs13314845 chr3:125644782 C/T cg02807482 chr3:125708958 NA -0.48 -5.66 -0.3 3.18e-8 Blood pressure (smoking interaction); LUSC trans rs8002861 0.664 rs2218497 chr13:44428793 G/A cg12856521 chr11:46389249 DGKZ 0.43 6.44 0.33 4.28e-10 Leprosy; LUSC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.39 6.17 0.32 1.93e-9 Intelligence (multi-trait analysis); LUSC cis rs113835537 0.502 rs7104378 chr11:66216675 A/G cg24851651 chr11:66362959 CCS 0.54 8.35 0.42 1.89e-15 Airway imaging phenotypes; LUSC cis rs4595586 0.545 rs6580888 chr12:39369704 C/T cg26384229 chr12:38710491 ALG10B 0.49 7.02 0.36 1.22e-11 Morning vs. evening chronotype; LUSC cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg05340658 chr4:99064831 C4orf37 0.68 11.58 0.54 2.71e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs8014204 0.566 rs12587457 chr14:75164141 C/T cg06637938 chr14:75390232 RPS6KL1 0.49 7.72 0.39 1.33e-13 Caffeine consumption; LUSC cis rs9560113 0.843 rs9555808 chr13:112181284 A/T cg14154082 chr13:112174009 NA 0.38 7.88 0.4 4.53e-14 Menarche (age at onset); LUSC cis rs11756438 0.572 rs2798328 chr6:119005378 C/T cg21191810 chr6:118973309 C6orf204 0.34 5.76 0.3 1.94e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10193935 1.000 rs10180528 chr2:42436723 T/A cg27598129 chr2:42591480 NA -0.62 -8.47 -0.42 7.97e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.54 6.82 0.35 4.15e-11 Renal function-related traits (BUN); LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs7923609 0.936 rs4405189 chr10:65013935 A/G cg01631684 chr10:65280961 REEP3 -0.43 -6.65 -0.34 1.18e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg22638593 chr5:131593259 PDLIM4 0.41 6.54 0.34 2.35e-10 Blood metabolite levels; LUSC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.36e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg13010199 chr12:38710504 ALG10B 0.7 10.88 0.51 8.7e-24 Morning vs. evening chronotype; LUSC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg22166914 chr1:53195759 ZYG11B 0.64 10.35 0.49 6.08e-22 Monocyte count; LUSC trans rs3749237 1.000 rs11717256 chr3:49868520 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.47 6.6 0.34 1.57e-10 Resting heart rate; LUSC cis rs7605827 0.930 rs7580672 chr2:15586646 A/G cg19274914 chr2:15703543 NA 0.48 9.21 0.45 3.65e-18 Educational attainment (years of education); LUSC trans rs57046232 0.552 rs1887412 chr20:6340856 A/G cg21095983 chr6:86352623 SYNCRIP 0.48 7.14 0.36 5.84e-12 Colorectal cancer; LUSC cis rs9527 0.569 rs10883801 chr10:104677887 A/C cg04362960 chr10:104952993 NT5C2 0.59 9.23 0.45 3.21e-18 Arsenic metabolism; LUSC cis rs611744 0.631 rs681963 chr8:109255032 C/A cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 7.89e-10 Dupuytren's disease; LUSC cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg15423357 chr2:25149977 NA 0.46 9.19 0.45 4.21e-18 Body mass index; LUSC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6840360 0.571 rs4696110 chr4:152671325 G/A cg22705602 chr4:152727874 NA -0.35 -7.63 -0.39 2.47e-13 Intelligence (multi-trait analysis); LUSC cis rs11048434 0.736 rs12812913 chr12:9110836 C/G cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg22963979 chr7:1858916 MAD1L1 -0.7 -11.66 -0.54 1.43e-26 Bipolar disorder and schizophrenia; LUSC cis rs1355223 0.583 rs2941043 chr11:34870994 A/G cg11058730 chr11:34937778 PDHX;APIP -0.68 -10.94 -0.51 5.22e-24 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs17336368 1.000 rs17336368 chr6:44751668 G/A cg20913747 chr6:44695427 NA -0.5 -8.36 -0.42 1.7e-15 Chin dimples; LUSC cis rs3768617 0.510 rs10797835 chr1:183072908 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.77 0.51 1.98e-23 Fuchs's corneal dystrophy; LUSC trans rs11992162 0.560 rs13276386 chr8:11797421 T/A cg15556689 chr8:8085844 FLJ10661 0.48 6.83 0.35 4.01e-11 Monocyte count; LUSC trans rs1908814 0.516 rs4841641 chr8:11798227 G/A cg06636001 chr8:8085503 FLJ10661 0.53 7.84 0.39 5.94e-14 Neuroticism; LUSC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg12463550 chr7:65579703 CRCP 0.51 7.38 0.37 1.26e-12 Aortic root size; LUSC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg27170947 chr2:26402098 FAM59B -0.63 -9.38 -0.46 1.04e-18 Gut microbiome composition (summer); LUSC cis rs4601821 0.895 rs7130431 chr11:113238223 A/C cg14159747 chr11:113255604 NA 0.25 5.86 0.31 1.11e-8 Alcoholic chronic pancreatitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18576635 chr6:137540623 IFNGR1 -0.46 -6.92 -0.35 2.25e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs1448094 1.000 rs4919776 chr12:86353763 T/C cg18827107 chr12:86230957 RASSF9 -0.39 -5.74 -0.3 2.1e-8 Major depressive disorder; LUSC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs1801251 1.000 rs283474 chr2:233654627 A/G cg25237894 chr2:233734115 C2orf82 0.34 5.82 0.3 1.39e-8 Coronary artery disease; LUSC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.33 0.49 6.71e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg01475377 chr6:109611718 NA -0.4 -7.25 -0.37 2.89e-12 Reticulocyte fraction of red cells; LUSC cis rs2425143 0.818 rs2378414 chr20:34534374 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -5.8 -0.3 1.53e-8 Blood protein levels; LUSC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg17971929 chr21:40555470 PSMG1 0.78 13.52 0.59 1.56e-33 Cognitive function; LUSC cis rs9916302 0.605 rs2879258 chr17:37399379 G/T cg07936489 chr17:37558343 FBXL20 -0.8 -9.89 -0.48 2.18e-20 Glomerular filtration rate (creatinine); LUSC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg21918786 chr6:109611834 NA -0.42 -7.29 -0.37 2.33e-12 Reticulocyte fraction of red cells; LUSC cis rs7589342 0.929 rs2060036 chr2:106436101 G/A cg16077055 chr2:106428750 NCK2 0.38 7.3 0.37 2.15e-12 Addiction; LUSC cis rs8062405 0.824 rs28772958 chr16:28535305 A/G cg16576597 chr16:28551801 NUPR1 0.28 5.65 0.3 3.52e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs12620999 0.774 rs2875726 chr2:237954576 T/C cg23555395 chr2:238036564 NA 0.41 6.92 0.35 2.25e-11 Systemic lupus erythematosus; LUSC cis rs7223966 1.000 rs8066719 chr17:61825764 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 7.18 0.37 4.69e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg18876405 chr7:65276391 NA -0.5 -7.85 -0.39 5.78e-14 Calcium levels; LUSC cis rs4631830 0.869 rs4131357 chr10:51537292 C/A cg16070123 chr10:51489643 NA -0.5 -8.01 -0.4 1.94e-14 Prostate-specific antigen levels; LUSC trans rs1908814 0.516 rs4840597 chr8:11796068 A/C cg15556689 chr8:8085844 FLJ10661 0.57 8.64 0.43 2.35e-16 Neuroticism; LUSC trans rs62238980 0.614 rs117535757 chr22:32373437 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg18357645 chr12:58087776 OS9 -0.53 -7.72 -0.39 1.37e-13 Celiac disease or Rheumatoid arthritis; LUSC trans rs11039798 0.512 rs11040205 chr11:49007360 G/C cg03929089 chr4:120376271 NA 0.7 7.63 0.39 2.45e-13 Axial length; LUSC cis rs6840360 0.967 rs6535815 chr4:152609700 A/C cg22705602 chr4:152727874 NA -0.31 -6.6 -0.34 1.58e-10 Intelligence (multi-trait analysis); LUSC cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg13010199 chr12:38710504 ALG10B 0.61 10.1 0.48 4.06e-21 Heart rate; LUSC cis rs35883536 0.588 rs955337 chr1:101108834 A/T cg06223162 chr1:101003688 GPR88 0.36 6.41 0.33 4.83e-10 Monocyte count; LUSC trans rs853679 0.556 rs45509595 chr6:27840926 T/C cg01620082 chr3:125678407 NA -0.83 -7.11 -0.36 7.11e-12 Depression; LUSC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1023500 0.573 rs133377 chr22:42466950 C/T cg04733989 chr22:42467013 NAGA 0.62 9.7 0.47 8.94e-20 Schizophrenia; LUSC cis rs453301 0.653 rs7005133 chr8:8901222 T/G cg06636001 chr8:8085503 FLJ10661 0.62 9.35 0.46 1.26e-18 Joint mobility (Beighton score); LUSC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg12365402 chr11:9010492 NRIP3 -0.49 -9.36 -0.46 1.18e-18 Hemoglobin concentration; LUSC trans rs9898058 0.943 rs17645899 chr17:47829551 C/T cg07356555 chr10:1284242 ADARB2 0.4 5.96 0.31 6.32e-9 Milk allergy; LUSC cis rs72634258 0.554 rs12092614 chr1:7865710 C/T cg26816564 chr1:7831052 VAMP3 0.93 13.06 0.58 9.01e-32 Inflammatory bowel disease; LUSC cis rs4919694 1.000 rs112240253 chr10:104753726 C/T cg04362960 chr10:104952993 NT5C2 1.18 13.62 0.6 6.87e-34 Arsenic metabolism; LUSC cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg04455712 chr21:45112962 RRP1B -0.47 -8.75 -0.43 1.11e-16 Mean corpuscular volume; LUSC cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.05 -0.36 1.03e-11 Menopause (age at onset); LUSC cis rs10743315 0.557 rs77782809 chr12:19364138 T/C cg02471346 chr12:19282374 PLEKHA5 0.78 6.28 0.33 1.03e-9 Gut microbiota (bacterial taxa); LUSC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.28 0.45 2.25e-18 Total body bone mineral density; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg07395648 chr5:131743802 NA 0.4 5.83 0.3 1.32e-8 Breast cancer; LUSC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs12681287 0.640 rs7832493 chr8:87371533 A/C cg27223183 chr8:87520930 FAM82B 0.55 7.38 0.37 1.27e-12 Caudate activity during reward; LUSC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.7 9.91 0.48 1.84e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11051970 0.659 rs950082 chr12:32588414 G/T cg02745156 chr12:32552066 NA 0.37 5.82 0.3 1.37e-8 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14435695 chr11:71950660 PHOX2A 0.41 6.35 0.33 7.18e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.38 0.37 1.3e-12 Motion sickness; LUSC trans rs11098499 0.697 rs10020027 chr4:120381879 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.44 0.33 4.04e-10 Corneal astigmatism; LUSC cis rs11105298 0.891 rs10506972 chr12:89861529 T/C cg00757033 chr12:89920650 WDR51B 0.6 10.33 0.49 7.01e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg11764359 chr7:65958608 NA -0.6 -8.9 -0.44 3.62e-17 Aortic root size; LUSC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg02423579 chr7:2872169 GNA12 0.48 7.28 0.37 2.42e-12 Height; LUSC cis rs3733418 1.000 rs3733419 chr4:165878170 A/G cg08992305 chr4:165878219 TRIM61;C4orf39 -0.49 -5.71 -0.3 2.44e-8 Obesity-related traits; LUSC cis rs9359856 0.600 rs17584763 chr6:90502088 G/A cg13799429 chr6:90582589 CASP8AP2 -0.83 -8.28 -0.41 3.05e-15 Bipolar disorder; LUSC cis rs72781680 0.848 rs56371415 chr2:23932603 C/G cg08917208 chr2:24149416 ATAD2B 1.0 10.16 0.49 2.55e-21 Lymphocyte counts; LUSC cis rs400736 0.894 rs226253 chr1:8027706 T/C cg25007680 chr1:8021821 PARK7 0.61 9.54 0.46 3.1e-19 Response to antidepressants and depression; LUSC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6591182 0.504 rs7130955 chr11:65372580 C/T cg05805236 chr11:65401703 PCNXL3 -0.53 -8.9 -0.44 3.72e-17 Non-alcoholic fatty liver disease histology (lobular); LUSC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg12463550 chr7:65579703 CRCP -0.57 -8.62 -0.43 2.65e-16 Aortic root size; LUSC cis rs8060686 0.516 rs8062085 chr16:68289313 C/A cg09835421 chr16:68378352 PRMT7 -0.52 -6.26 -0.32 1.16e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs34421088 0.532 rs2736385 chr8:11148613 T/C cg21775007 chr8:11205619 TDH 0.51 7.43 0.38 9.28e-13 Neuroticism; LUSC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg24642439 chr20:33292090 TP53INP2 -0.48 -7.2 -0.37 4.05e-12 Glomerular filtration rate (creatinine); LUSC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg16797656 chr11:68205561 LRP5 0.39 7.14 0.36 5.87e-12 Total body bone mineral density; LUSC cis rs9527 0.590 rs4917992 chr10:104786313 G/A cg23093090 chr10:104574429 C10orf26 -0.34 -6.15 -0.32 2.2e-9 Arsenic metabolism; LUSC trans rs60843830 1.000 rs10193373 chr2:281886 T/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 10.76 0.51 2.28e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9359856 0.510 rs6937789 chr6:90468775 C/G cg13799429 chr6:90582589 CASP8AP2 0.92 11.01 0.52 3.02e-24 Bipolar disorder; LUSC cis rs4700695 0.719 rs27046 chr5:65439964 G/C cg21114390 chr5:65439923 SFRS12 -0.62 -8.74 -0.43 1.19e-16 Facial morphology (factor 19); LUSC cis rs9325144 0.600 rs6582634 chr12:38748041 G/A cg13010199 chr12:38710504 ALG10B 0.48 7.39 0.38 1.16e-12 Morning vs. evening chronotype; LUSC cis rs7264396 0.790 rs6060526 chr20:34225302 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.66 9.92 0.48 1.65e-20 Total cholesterol levels; LUSC trans rs2729385 1.000 rs2729385 chr11:57262993 C/T cg08276543 chr12:124856791 NCOR2 -0.45 -6.04 -0.31 4.15e-9 Interleukin-18 levels; LUSC trans rs1973993 0.689 rs17115225 chr1:96884330 C/T cg10631902 chr5:14652156 NA -0.54 -8.07 -0.4 1.29e-14 Weight; LUSC cis rs9549367 0.789 rs2287251 chr13:113889499 A/G cg00898013 chr13:113819073 PROZ -0.57 -8.12 -0.41 9.33e-15 Platelet distribution width; LUSC trans rs7618501 0.633 rs6792892 chr3:49995518 T/C cg21659725 chr3:3221576 CRBN 0.64 10.6 0.5 7.9e-23 Intelligence (multi-trait analysis); LUSC cis rs4727027 0.704 rs12704083 chr7:148909759 G/A cg23158103 chr7:148848205 ZNF398 -0.45 -7.32 -0.37 1.89e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs34779708 0.966 rs17499811 chr10:35456215 G/A cg04310649 chr10:35416472 CREM -0.42 -6.45 -0.33 3.9e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4947962 0.585 rs17172432 chr7:55141317 C/T cg23757825 chr7:55092271 EGFR 0.46 6.34 0.33 7.3e-10 Subjective response to lithium treatment; LUSC cis rs7296418 0.922 rs12425009 chr12:123502044 C/T cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.35 -0.42 1.8e-15 Platelet count; LUSC cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg26384229 chr12:38710491 ALG10B -0.83 -14.16 -0.61 5.71e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs4704187 0.687 rs4621537 chr5:74362222 A/G cg03227963 chr5:74354835 NA 0.33 7.02 0.36 1.28e-11 Response to amphetamines; LUSC cis rs79149102 0.579 rs12591994 chr15:75320306 A/G cg17294928 chr15:75287854 SCAMP5 -0.76 -6.61 -0.34 1.49e-10 Lung cancer; LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg12564285 chr5:131593104 PDLIM4 -0.56 -10.62 -0.5 7.09e-23 Acylcarnitine levels; LUSC cis rs7577851 0.585 rs67347664 chr2:69664921 A/T cg10773587 chr2:69614142 GFPT1 0.53 5.86 0.31 1.11e-8 Parkinson's disease (age of onset); LUSC cis rs11864453 0.713 rs2241412 chr16:72144284 A/G cg01557791 chr16:72042693 DHODH -0.47 -6.92 -0.35 2.28e-11 Fibrinogen levels; LUSC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg06238570 chr21:40685208 BRWD1 0.49 7.46 0.38 7.78e-13 Cognitive function; LUSC cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg00310523 chr12:86230176 RASSF9 0.47 8.47 0.42 7.74e-16 Major depressive disorder; LUSC cis rs6076065 0.723 rs743024 chr20:23342476 C/T cg11657817 chr20:23433608 CST11 -0.43 -8.2 -0.41 5.21e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg18402987 chr7:1209562 NA 0.73 7.85 0.39 5.7e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg06558623 chr16:89946397 TCF25 1.11 9.74 0.47 6.79e-20 Skin colour saturation; LUSC cis rs28374715 0.532 rs28703570 chr15:41679492 G/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -24.39 -0.8 3.65e-76 Ulcerative colitis; LUSC cis rs17001868 0.568 rs9611325 chr22:40782490 G/A cg07138101 chr22:40742427 ADSL 0.62 7.59 0.38 3.22e-13 Mammographic density (dense area); LUSC cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg19508488 chr2:152266495 RIF1 0.53 7.6 0.38 3.08e-13 Lung cancer; LUSC cis rs62400317 0.859 rs10948211 chr6:45156767 G/A cg20913747 chr6:44695427 NA -0.48 -7.69 -0.39 1.63e-13 Total body bone mineral density; LUSC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.3 -0.53 2.78e-25 Mean corpuscular volume; LUSC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg26513180 chr16:89883248 FANCA 0.79 6.38 0.33 5.88e-10 Skin colour saturation; LUSC trans rs2197308 0.626 rs6581156 chr12:37858731 C/A cg06521331 chr12:34319734 NA 0.4 6.42 0.33 4.7e-10 Morning vs. evening chronotype; LUSC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg03161606 chr19:29218774 NA 0.63 9.79 0.47 4.79e-20 Methadone dose in opioid dependence; LUSC cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg14552801 chr7:65878734 NA -0.48 -6.67 -0.34 1.06e-10 Aortic root size; LUSC cis rs11971779 0.680 rs7779900 chr7:139082987 G/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg24692254 chr21:30365293 RNF160 0.76 12.16 0.55 2.07e-28 Selective IgA deficiency; LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg08736216 chr1:53307985 ZYG11A 0.28 5.74 0.3 2.12e-8 Monocyte count; LUSC cis rs11168618 1.000 rs11168621 chr12:48938971 G/A cg24011408 chr12:48396354 COL2A1 0.4 6.37 0.33 6.34e-10 Adiponectin levels; LUSC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg04733989 chr22:42467013 NAGA 0.41 6.68 0.34 1.02e-10 Cognitive function; LUSC cis rs372883 0.935 rs1153295 chr21:30704080 T/G cg08807101 chr21:30365312 RNF160 -0.41 -5.89 -0.31 9.54e-9 Pancreatic cancer; LUSC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg10523679 chr1:76189770 ACADM 0.86 11.39 0.53 1.29e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg21573476 chr21:45109991 RRP1B 0.39 6.36 0.33 6.74e-10 Mean corpuscular volume; LUSC cis rs4663866 0.803 rs71426511 chr2:239180200 G/A cg16914508 chr2:239161102 PER2 0.68 7.25 0.37 3.01e-12 Irritable bowel syndrome; LUSC cis rs7100689 0.555 rs1934146 chr10:82062121 C/A cg01528321 chr10:82214614 TSPAN14 0.83 12.44 0.56 1.93e-29 Post bronchodilator FEV1; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.51 0.78 6.17e-69 Prudent dietary pattern; LUSC cis rs1008375 0.843 rs59112113 chr4:17685336 A/T cg16339924 chr4:17578868 LAP3 0.55 8.51 0.42 6.11e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.52e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.69 0.83 1.71e-88 Chronic sinus infection; LUSC cis rs2050392 0.767 rs10763786 chr10:30693567 G/C cg25182066 chr10:30743637 MAP3K8 0.43 6.07 0.32 3.41e-9 Inflammatory bowel disease; LUSC cis rs116988415 0.584 rs2269305 chr14:65245650 C/G cg00114569 chr14:65239327 SPTB 0.61 6.62 0.34 1.4e-10 Daytime sleep phenotypes; LUSC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg19920283 chr7:105172520 RINT1 0.59 6.32 0.33 8.44e-10 Bipolar disorder (body mass index interaction); LUSC cis rs4400599 0.618 rs4393149 chr1:154195753 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.02 -0.31 4.47e-9 Platelet distribution width; LUSC cis rs9790314 0.586 rs1811483 chr3:161130900 A/G cg03342759 chr3:160939853 NMD3 -0.44 -6.56 -0.34 2.05e-10 Morning vs. evening chronotype; LUSC cis rs3733585 0.654 rs4447863 chr4:9938969 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.17 -0.45 4.9e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7296418 0.630 rs28419092 chr12:123812629 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.53 -0.34 2.44e-10 Platelet count; LUSC cis rs3087591 0.920 rs11080150 chr17:29629326 A/G cg24425628 chr17:29625626 OMG;NF1 -0.62 -8.9 -0.44 3.6e-17 Hip circumference; LUSC trans rs34421088 0.506 rs2572426 chr8:11147123 C/T cg06636001 chr8:8085503 FLJ10661 0.5 7.43 0.38 9.47e-13 Neuroticism; LUSC cis rs1451375 0.652 rs7803903 chr7:50625945 C/T cg18232548 chr7:50535776 DDC 0.48 6.53 0.34 2.49e-10 Malaria; LUSC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.82 -0.51 1.33e-23 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08871383 chr2:46524363 EPAS1 -0.42 -6.15 -0.32 2.23e-9 Electrocardiographic conduction measures; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg10819733 chr22:24237672 NA -0.4 -6.02 -0.31 4.59e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg10057126 chr4:77819792 ANKRD56 0.51 7.63 0.39 2.51e-13 Emphysema distribution in smoking; LUSC cis rs28735056 0.592 rs12455965 chr18:77688830 G/C cg20368463 chr18:77673604 PQLC1 -0.71 -10.99 -0.52 3.54e-24 Schizophrenia; LUSC cis rs4891159 0.790 rs9950025 chr18:74113596 C/G cg24786174 chr18:74118243 ZNF516 0.83 15.28 0.64 2.51e-40 Longevity; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03001875 chr1:234614834 TARBP1 0.76 5.99 0.31 5.36e-9 Cognitive performance; LUSC cis rs1997103 1.000 rs2877284 chr7:55408778 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg04362960 chr10:104952993 NT5C2 -0.47 -6.11 -0.32 2.76e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2853333 0.935 rs1894232 chr19:35754511 C/G cg12287945 chr19:35758300 LSR -0.39 -6.06 -0.31 3.73e-9 Red blood cell count; LUSC cis rs7432375 0.610 rs6793936 chr3:136509793 A/C cg21827317 chr3:136751795 NA 0.32 5.65 0.3 3.35e-8 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs59698941 0.943 rs67656232 chr5:132254426 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.55 5.8 0.3 1.5e-8 Cerebrospinal P-tau181p levels; LUSC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg22681709 chr2:178499509 PDE11A -0.51 -9.18 -0.45 4.78e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.14 0.45 6.25e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs6120849 0.754 rs17319032 chr20:33643296 T/C cg24642439 chr20:33292090 TP53INP2 0.6 6.58 0.34 1.8e-10 Protein C levels; LUSC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg13114125 chr14:105738426 BRF1 -0.95 -15.95 -0.66 5.69e-43 Mean platelet volume;Platelet distribution width; LUSC trans rs724744 0.741 rs1737226 chr6:22352868 C/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.2 -0.32 1.71e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16863872 chr21:45526972 PWP2 -0.43 -6.19 -0.32 1.72e-9 Electrocardiographic conduction measures; LUSC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg21435336 chr19:17392852 ANKLE1 -0.47 -6.22 -0.32 1.52e-9 Systemic lupus erythematosus; LUSC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg09365446 chr1:150670422 GOLPH3L 0.49 7.17 0.37 4.77e-12 Melanoma; LUSC cis rs8017423 0.935 rs3737035 chr14:90745422 T/C cg04374321 chr14:90722782 PSMC1 -0.68 -10.35 -0.49 5.96e-22 Mortality in heart failure; LUSC cis rs4073416 0.508 rs11844682 chr14:65910844 G/C cg03016385 chr14:66212404 NA -0.38 -5.66 -0.3 3.35e-8 N-glycan levels; LUSC cis rs7572733 0.534 rs10211202 chr2:198771941 A/G cg00792783 chr2:198669748 PLCL1 0.45 6.03 0.31 4.26e-9 Dermatomyositis; LUSC cis rs988712 0.705 rs4244531 chr11:27657250 A/G cg10635145 chr11:27742435 BDNF -0.47 -6.16 -0.32 2.09e-9 Obesity; LUSC trans rs35110281 0.807 rs4818850 chr21:45028071 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.1 0.48 4.12e-21 Mean corpuscular volume; LUSC cis rs11690935 1.000 rs312918 chr2:172569587 C/G cg13550731 chr2:172543902 DYNC1I2 -0.91 -15.7 -0.65 5.6e-42 Schizophrenia; LUSC trans rs9944715 0.954 rs6507680 chr18:43766986 A/C cg01718231 chr17:29326311 RNF135 -0.49 -7.06 -0.36 9.55e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg06718696 chr17:78121285 EIF4A3 0.78 11.61 0.54 2.07e-26 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg07677032 chr17:61819896 STRADA 0.55 9.2 0.45 4.08e-18 Prudent dietary pattern; LUSC cis rs6087771 0.662 rs6058298 chr20:30247916 C/T cg18721089 chr20:30220636 NA -0.32 -5.7 -0.3 2.66e-8 Subcortical brain region volumes;Putamen volume; LUSC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg19230755 chr7:65878503 NA -0.41 -5.82 -0.3 1.36e-8 Aortic root size; LUSC cis rs6960043 0.782 rs4721401 chr7:15064896 T/G cg19272540 chr7:15055459 NA -0.32 -7.88 -0.4 4.75e-14 Type 2 diabetes; LUSC cis rs8078723 1.000 rs3826331 chr17:38150492 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.42 6.72 0.35 7.9e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg23796481 chr11:64053134 BAD;GPR137 -0.4 -6.64 -0.34 1.25e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs12541635 0.771 rs12155864 chr8:107105491 C/T cg10147462 chr8:107024639 NA -0.45 -7.99 -0.4 2.18e-14 Age of smoking initiation; LUSC trans rs2797160 1.000 rs2797160 chr6:126010116 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs2717559 0.542 rs11774823 chr8:143887568 G/T cg17252645 chr8:143867129 LY6D -0.56 -10.6 -0.5 7.81e-23 Urinary tract infection frequency; LUSC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs2204008 0.583 rs12307593 chr12:38317803 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.99 0.36 1.5e-11 Bladder cancer; LUSC cis rs9311676 0.656 rs6445977 chr3:58379560 T/C cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs9287719 0.625 rs12473787 chr2:10717194 G/C cg00105475 chr2:10696890 NA 0.34 5.7 0.3 2.67e-8 Prostate cancer; LUSC cis rs4730250 0.634 rs11767623 chr7:106792332 C/T cg02696742 chr7:106810147 HBP1 0.64 9.04 0.44 1.32e-17 Osteoarthritis; LUSC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg11764359 chr7:65958608 NA -0.7 -10.85 -0.51 1.07e-23 Aortic root size; LUSC cis rs2204008 0.805 rs12146846 chr12:37985847 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.92 0.51 5.92e-24 Bladder cancer; LUSC cis rs6961069 0.585 rs13225492 chr7:80240837 A/G cg04458919 chr7:80252533 CD36 -0.39 -6.91 -0.35 2.41e-11 Platelet count; LUSC cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs61931739 0.500 rs7303318 chr12:34467789 T/C cg06521331 chr12:34319734 NA -0.42 -6.91 -0.35 2.41e-11 Morning vs. evening chronotype; LUSC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg01770232 chr7:22766155 IL6 0.4 5.76 0.3 1.89e-8 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06755612 chr14:45603778 FKBP3;FANCM -0.48 -6.35 -0.33 7.23e-10 Bipolar disorder and schizophrenia; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC trans rs9354352 0.784 rs2062327 chr6:66689923 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.63 -9.01 -0.44 1.64e-17 Initial pursuit acceleration in psychotic disorders; LUSC cis rs10911232 0.507 rs3934697 chr1:183027512 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.15 0.52 9.13e-25 Hypertriglyceridemia; LUSC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg18758796 chr5:131593413 PDLIM4 0.35 6.27 0.32 1.11e-9 Blood metabolite levels; LUSC cis rs1160297 0.576 rs13003962 chr2:53110176 C/T cg07782112 chr2:53107842 NA 0.43 7.12 0.36 6.85e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs4356932 1.000 rs6848603 chr4:76973521 G/A cg00809888 chr4:76862425 NAAA 0.35 5.82 0.3 1.39e-8 Blood protein levels; LUSC cis rs7681440 0.904 rs7698219 chr4:90771351 C/A cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.18e-8 Dementia with Lewy bodies; LUSC cis rs4242434 0.689 rs4872006 chr8:22536502 T/C cg03733263 chr8:22462867 KIAA1967 -0.78 -12.84 -0.58 5.77e-31 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.42 0.33 4.63e-10 Cerebrospinal P-tau181p levels; LUSC cis rs9473147 0.543 rs4715019 chr6:47447041 T/A cg02130027 chr6:47444894 CD2AP 0.35 5.67 0.3 3.01e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg24692254 chr21:30365293 RNF160 0.92 19.45 0.73 6.89e-57 Dental caries; LUSC cis rs710865 0.966 rs709683 chr1:19565344 C/G cg13387374 chr1:19411106 UBR4 0.44 6.33 0.33 8.06e-10 Brain structure; LUSC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg11001216 chr19:58859029 A1BG 0.44 5.77 0.3 1.86e-8 Mean platelet volume; LUSC cis rs7771547 0.519 rs7773253 chr6:36373451 T/A cg07856975 chr6:36356162 ETV7 0.44 6.43 0.33 4.32e-10 Platelet distribution width; LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18301423 chr5:131593218 PDLIM4 0.46 7.01 0.36 1.34e-11 Acylcarnitine levels; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg24846343 chr22:24311635 DDTL 0.68 14.47 0.62 3.43e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg08999081 chr20:33150536 PIGU 0.44 8.19 0.41 5.6e-15 Coronary artery disease; LUSC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg16434002 chr17:42200994 HDAC5 -0.46 -6.57 -0.34 1.98e-10 Total body bone mineral density; LUSC cis rs644799 0.526 rs530914 chr11:95632156 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.6 8.74 0.43 1.15e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg00701064 chr4:6280414 WFS1 -0.6 -13.48 -0.59 2.3e-33 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs748404 0.697 rs1095389 chr15:43566671 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.72 0.43 1.38e-16 Lung cancer; LUSC cis rs9325144 0.560 rs10506125 chr12:39120287 C/T cg13010199 chr12:38710504 ALG10B 0.51 8.16 0.41 6.87e-15 Morning vs. evening chronotype; LUSC cis rs4664308 0.935 rs4637057 chr2:160950161 G/T cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg05347473 chr6:146136440 FBXO30 0.52 9.05 0.44 1.23e-17 Lobe attachment (rater-scored or self-reported); LUSC trans rs62103177 0.584 rs9956207 chr18:77968392 A/G cg05926928 chr17:57297772 GDPD1 -0.69 -7.15 -0.36 5.36e-12 Opioid sensitivity; LUSC cis rs2073300 1.000 rs6132628 chr20:23446734 G/A cg12062639 chr20:23401060 NAPB 0.77 5.99 0.31 5.55e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg22875332 chr1:76189707 ACADM -0.75 -10.33 -0.49 6.69e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg16060761 chr17:80687452 NA -0.5 -7.89 -0.4 4.42e-14 Glycated hemoglobin levels; LUSC cis rs7119167 0.901 rs880317 chr11:73108276 A/G cg17517138 chr11:73019481 ARHGEF17 0.56 6.35 0.33 7.22e-10 Blood protein levels; LUSC cis rs763121 0.925 rs5757251 chr22:39100128 G/A cg06022373 chr22:39101656 GTPBP1 0.79 12.83 0.57 6.52e-31 Menopause (age at onset); LUSC cis rs709400 0.663 rs7145113 chr14:103945414 A/G cg24130564 chr14:104152367 KLC1 -0.43 -6.12 -0.32 2.66e-9 Body mass index; LUSC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg08219700 chr8:58056026 NA 0.49 6.27 0.32 1.14e-9 Developmental language disorder (linguistic errors); LUSC cis rs2933343 0.700 rs2249514 chr3:128643812 C/T cg11901034 chr3:128598214 ACAD9 -0.41 -6.47 -0.33 3.54e-10 IgG glycosylation; LUSC cis rs7954584 0.583 rs6486782 chr12:122359172 T/C cg22618164 chr12:122356400 WDR66 0.55 7.8 0.39 8.09e-14 Mean corpuscular volume; LUSC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.11 0.32 2.78e-9 Mean platelet volume; LUSC cis rs8180040 0.764 rs13061071 chr3:47138708 G/A cg16586182 chr3:47516702 SCAP -0.5 -7.73 -0.39 1.31e-13 Colorectal cancer; LUSC cis rs4820539 0.966 rs2157709 chr22:23457420 T/C cg14186256 chr22:23484241 RTDR1 0.95 17.5 0.69 4.06e-49 Bone mineral density; LUSC cis rs9457247 0.602 rs13204839 chr6:167471119 G/A cg06454157 chr6:167490870 NA -0.29 -6.78 -0.35 5.52e-11 Crohn's disease; LUSC cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs3862030 0.810 rs11593710 chr10:104328719 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.81 -0.51 1.53e-23 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs1568889 0.877 rs17310076 chr11:28147590 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.57 6.78 0.35 5.43e-11 Bipolar disorder; LUSC cis rs394563 0.534 rs388335 chr6:149791986 T/C cg11245181 chr6:149772854 ZC3H12D -0.41 -7.85 -0.39 5.82e-14 Dupuytren's disease; LUSC cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.97 -0.36 1.75e-11 Menopause (age at onset); LUSC cis rs748404 0.631 rs2412781 chr15:43667900 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.43 -6.11 -0.32 2.72e-9 Lung cancer; LUSC cis rs2455826 0.874 rs2455853 chr3:15690025 C/T cg09340198 chr3:15902540 ANKRD28 -0.37 -5.79 -0.3 1.66e-8 Inflammatory skin disease; LUSC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg24154853 chr7:158122151 PTPRN2 0.45 8.88 0.44 4.06e-17 Calcium levels; LUSC cis rs6845621 0.901 rs11725033 chr4:18929234 G/A cg12196642 chr4:18937545 NA -0.37 -6.81 -0.35 4.59e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2070488 0.689 rs6809352 chr3:38544349 G/A cg24069376 chr3:38537580 EXOG -0.4 -7.8 -0.39 7.78e-14 Electrocardiographic conduction measures; LUSC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg00343986 chr7:65444356 GUSB 0.44 6.72 0.35 7.92e-11 Aortic root size; LUSC cis rs981844 1.000 rs2579916 chr4:154659972 G/T cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg06060754 chr5:176797920 RGS14 0.6 9.61 0.47 1.78e-19 Hemoglobin concentration;Hematocrit; LUSC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg13607699 chr17:42295918 UBTF 0.47 7.56 0.38 3.83e-13 Total body bone mineral density; LUSC cis rs8032315 0.965 rs7497304 chr15:91429176 G/T cg05469396 chr15:91419421 FURIN -0.42 -6.67 -0.34 1.05e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs1348850 0.651 rs4893935 chr2:178240601 C/G cg22681709 chr2:178499509 PDE11A -0.34 -6.36 -0.33 6.47e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.14 0.41 8.18e-15 Prudent dietary pattern; LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg04166393 chr7:2884313 GNA12 0.45 5.93 0.31 7.55e-9 Height; LUSC cis rs57590327 0.503 rs6802480 chr3:81906671 G/A cg07356753 chr3:81810745 GBE1 -0.66 -10.49 -0.5 2e-22 Extraversion; LUSC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.46 -6.72 -0.35 7.85e-11 Menarche (age at onset); LUSC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg10523679 chr1:76189770 ACADM 0.86 14.15 0.61 6.09e-36 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs2243480 1.000 rs56016656 chr7:65383481 C/T cg10756647 chr7:56101905 PSPH 0.89 8.61 0.43 2.86e-16 Diabetic kidney disease; LUSC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.75 -0.35 6.36e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9467773 1.000 rs10484442 chr6:26555879 A/G cg09904177 chr6:26538194 HMGN4 0.75 14.0 0.61 2.38e-35 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.545 rs3858554 chr12:39381460 C/T cg26384229 chr12:38710491 ALG10B 0.49 7.13 0.36 6.29e-12 Morning vs. evening chronotype; LUSC cis rs12586317 0.620 rs17091786 chr14:35565856 A/T cg16230307 chr14:35515116 FAM177A1 0.8 10.11 0.48 3.96e-21 Psoriasis; LUSC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg10523679 chr1:76189770 ACADM -0.78 -10.7 -0.51 3.54e-23 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.48 0.42 7.53e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3087591 0.960 rs2071009 chr17:29558082 T/C cg24425628 chr17:29625626 OMG;NF1 -0.58 -8.42 -0.42 1.1e-15 Hip circumference; LUSC cis rs11229555 0.574 rs12272096 chr11:58186118 A/G cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6545883 1.000 rs778763 chr2:61785639 C/G cg15711740 chr2:61764176 XPO1 -0.5 -7.99 -0.4 2.23e-14 Tuberculosis; LUSC cis rs11711311 1.000 rs12637067 chr3:113527606 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.88 0.35 2.9e-11 IgG glycosylation; LUSC cis rs9325144 0.513 rs12313652 chr12:38665412 G/A cg13010199 chr12:38710504 ALG10B -0.51 -7.67 -0.39 1.87e-13 Morning vs. evening chronotype; LUSC cis rs9715521 0.677 rs6822690 chr4:59853530 A/G cg11281224 chr4:60001000 NA -0.51 -7.06 -0.36 9.42e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs17818399 0.547 rs7607633 chr2:46759427 T/C cg02822958 chr2:46747628 ATP6V1E2 0.42 6.09 0.32 3.07e-9 Height; LUSC cis rs9300255 0.602 rs2851450 chr12:123703501 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg05861140 chr6:150128134 PCMT1 -0.45 -7.17 -0.37 4.83e-12 Lung cancer; LUSC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg25072359 chr17:41440525 NA 0.69 9.81 0.47 4.02e-20 Menopause (age at onset); LUSC cis rs17125944 0.615 rs1998779 chr14:53295950 T/A cg00686598 chr14:53173677 PSMC6 -0.67 -6.4 -0.33 5.36e-10 Alzheimer's disease (late onset); LUSC cis rs637571 0.522 rs528736 chr11:65705108 A/G cg26695010 chr11:65641043 EFEMP2 -0.48 -6.84 -0.35 3.78e-11 Eosinophil percentage of white cells; LUSC trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg25482853 chr8:67687455 SGK3 1.2 17.23 0.69 4.62e-48 Lung disease severity in cystic fibrosis; LUSC cis rs17253792 0.822 rs77741349 chr14:56097462 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg07362569 chr17:61921086 SMARCD2 0.38 7.9 0.4 3.97e-14 Prudent dietary pattern; LUSC cis rs1538970 0.961 rs884962 chr1:45847981 G/A cg05343316 chr1:45956843 TESK2 0.61 8.49 0.42 6.97e-16 Platelet count; LUSC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg22535103 chr8:58192502 C8orf71 -0.56 -6.65 -0.34 1.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Melanoma; LUSC cis rs2635047 0.811 rs12957869 chr18:44786869 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 5.73 0.3 2.21e-8 Educational attainment; LUSC cis rs7119 0.700 rs57471224 chr15:77888169 A/G cg27398640 chr15:77910606 LINGO1 0.37 8.59 0.43 3.27e-16 Type 2 diabetes; LUSC trans rs3942852 0.955 rs7117386 chr11:48125371 G/A cg03929089 chr4:120376271 NA -0.55 -6.33 -0.33 8.09e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs9503598 0.636 rs6596974 chr6:3465833 C/T cg00476032 chr6:3446245 SLC22A23 0.31 6.02 0.31 4.71e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs9308433 1.000 rs9308433 chr1:214457009 T/C cg06198575 chr1:214491504 SMYD2 0.44 6.85 0.35 3.47e-11 IgG glycosylation; LUSC cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg08754478 chr10:133766260 PPP2R2D -0.62 -7.71 -0.39 1.46e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg12419862 chr22:24373484 LOC391322 -0.88 -14.59 -0.62 1.23e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4319547 0.698 rs4039670 chr12:122822655 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.42 -0.46 7.52e-19 Body mass index; LUSC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 10.24 0.49 1.35e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg08470875 chr2:26401718 FAM59B -0.66 -8.78 -0.43 8.93e-17 Gut microbiome composition (summer); LUSC cis rs28374715 0.662 rs691906 chr15:41474636 T/A cg18705301 chr15:41695430 NDUFAF1 0.81 14.85 0.63 1.19e-38 Ulcerative colitis; LUSC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg02034447 chr16:89574710 SPG7 0.44 6.46 0.33 3.73e-10 Multiple myeloma (IgH translocation); LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.49 0.53 5.51e-26 Prudent dietary pattern; LUSC cis rs939658 0.875 rs2177057 chr15:79441441 G/C cg17916960 chr15:79447300 NA -0.53 -10.59 -0.5 8.48e-23 Refractive error; LUSC cis rs1568889 1.000 rs7934085 chr11:28369660 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.44 0.46 6.68e-19 Bipolar disorder; LUSC cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg17845761 chr1:175162550 KIAA0040 0.31 5.98 0.31 5.7e-9 Alcohol dependence; LUSC cis rs2012796 0.704 rs57670850 chr14:81841577 C/T cg02996355 chr14:81879375 NA 0.58 8.25 0.41 3.71e-15 Night sleep phenotypes; LUSC trans rs2018683 0.707 rs1874974 chr7:28967647 G/C cg19402173 chr7:128379420 CALU -0.45 -6.78 -0.35 5.46e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs9807989 0.839 rs11695627 chr2:102970105 A/G cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg07701084 chr6:150067640 NUP43 0.57 8.82 0.43 6.43e-17 Lung cancer; LUSC cis rs6840360 0.615 rs28659854 chr4:152607442 T/C cg22705602 chr4:152727874 NA -0.37 -7.89 -0.4 4.32e-14 Intelligence (multi-trait analysis); LUSC cis rs7572644 0.760 rs9309659 chr2:28326258 C/G cg27432699 chr2:27873401 GPN1 0.48 6.72 0.35 7.92e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg02269571 chr22:50332266 NA -0.57 -8.69 -0.43 1.68e-16 Schizophrenia; LUSC cis rs554111 0.634 rs1453265 chr1:21277711 C/T cg01072550 chr1:21505969 NA 0.41 6.23 0.32 1.39e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.17e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1670533 1.000 rs6822863 chr4:1055606 G/A cg02018176 chr4:1364513 KIAA1530 0.43 6.0 0.31 5.18e-9 Recombination rate (females); LUSC cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg11244672 chr19:19639970 YJEFN3 -0.61 -7.24 -0.37 3.03e-12 Bipolar disorder; LUSC cis rs16854884 0.657 rs2099543 chr3:143742164 C/T cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg11859384 chr17:80120422 CCDC57 0.36 5.69 0.3 2.71e-8 Life satisfaction; LUSC cis rs6494488 0.500 rs72744725 chr15:65023953 T/C cg08069370 chr15:64387884 SNX1 -0.58 -5.66 -0.3 3.23e-8 Coronary artery disease; LUSC cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg03146154 chr1:46216737 IPP 0.55 8.27 0.41 3.11e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs73206853 0.563 rs17682444 chr12:111154626 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.74 0.35 7.01e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15238519 chr22:50683529 TUBGCP6 -0.55 -6.82 -0.35 4.24e-11 Bipolar disorder and schizophrenia; LUSC cis rs6933660 0.512 rs13198669 chr6:151799924 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.55 -5.7 -0.3 2.61e-8 Menarche (age at onset); LUSC cis rs77633900 0.772 rs4886492 chr15:76672817 T/A cg21673338 chr15:77095150 SCAPER 0.68 6.12 0.32 2.67e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs10276303 0.502 rs11768500 chr7:3396320 A/G cg21248987 chr7:3385318 SDK1 -0.4 -6.67 -0.34 1.05e-10 Dupuytren's disease; LUSC cis rs6674970 1.000 rs7546304 chr1:151114484 C/G cg11822372 chr1:151115635 SEMA6C 0.55 8.45 0.42 9.26e-16 Childhood ear infection; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.5 6.87 0.35 3.24e-11 Renal function-related traits (BUN); LUSC cis rs9323205 0.723 rs12147193 chr14:51748063 A/G cg23942311 chr14:51606299 NA -0.43 -8.03 -0.4 1.72e-14 Cancer; LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.52 0.38 5.09e-13 Prudent dietary pattern; LUSC cis rs11048434 0.761 rs10842662 chr12:9139344 G/A cg13575925 chr12:9217583 LOC144571 0.34 6.28 0.32 1.07e-9 Sjögren's syndrome; LUSC cis rs17286411 0.806 rs952159 chr16:71965915 G/A cg03805757 chr16:71968109 PKD1L3 0.39 5.68 0.3 2.91e-8 Blood protein levels; LUSC cis rs68092024 0.731 rs792840 chr3:99471251 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 7.13 0.36 6.11e-12 Cleft lip with or without cleft palate; LUSC cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.2 -0.32 1.63e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg27094323 chr7:1216898 NA -0.43 -7.19 -0.37 4.2e-12 Longevity;Endometriosis; LUSC cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg03146154 chr1:46216737 IPP 0.54 7.8 0.39 7.79e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg01973587 chr1:228161476 NA 0.46 8.45 0.42 9.2e-16 Diastolic blood pressure; LUSC cis rs4690686 0.500 rs7657249 chr4:177275198 A/G cg17059388 chr4:177262070 NA 0.48 8.81 0.43 6.95e-17 Essential tremor; LUSC cis rs11148252 0.574 rs3742297 chr13:53278067 T/C cg02158880 chr13:53174818 NA 0.58 10.42 0.5 3.39e-22 Lewy body disease; LUSC cis rs4604732 0.603 rs4546958 chr1:247639478 G/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.36 5.82 0.3 1.38e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7824557 0.767 rs6985460 chr8:11171087 A/C cg21775007 chr8:11205619 TDH 0.69 10.79 0.51 1.78e-23 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg07677032 chr17:61819896 STRADA 0.52 8.62 0.43 2.78e-16 Prudent dietary pattern; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg07395648 chr5:131743802 NA -0.4 -5.88 -0.31 1e-8 Breast cancer; LUSC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.87 -0.4 4.88e-14 Reticulocyte count; LUSC cis rs367615 0.679 rs4259216 chr5:108841817 A/G cg17395555 chr5:108820864 NA 0.62 11.39 0.53 1.32e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs17621444 0.505 rs10886578 chr10:121797264 G/A cg02041677 chr10:121771263 NA -0.36 -6.59 -0.34 1.69e-10 IgG glycosylation; LUSC cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg08684580 chr7:98029266 BAIAP2L1 0.36 6.32 0.33 8.45e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1801251 1.000 rs283468 chr2:233658309 C/T cg08000102 chr2:233561755 GIGYF2 0.75 11.7 0.54 9.96e-27 Coronary artery disease; LUSC cis rs10995240 1 rs10995240 chr10:64388631 G/C cg03961010 chr10:64397487 ZNF365 -0.43 -6.69 -0.34 9.6e-11 Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg08219700 chr8:58056026 NA 0.5 6.57 0.34 1.98e-10 Developmental language disorder (linguistic errors); LUSC cis rs9976767 0.608 rs3746923 chr21:43826344 C/T cg23042151 chr21:43824109 UBASH3A -0.33 -6.48 -0.33 3.21e-10 Type 1 diabetes; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg00684032 chr4:1343700 KIAA1530 0.34 6.13 0.32 2.49e-9 Obesity-related traits; LUSC cis rs9611565 0.694 rs4822032 chr22:41925535 T/C cg03806693 chr22:41940476 POLR3H -0.83 -11.85 -0.54 2.87e-27 Vitiligo; LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.79e-8 Depression; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg13560548 chr3:10150139 C3orf24 0.54 7.12 0.36 6.45e-12 Alzheimer's disease; LUSC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.08 -0.36 8.61e-12 Total body bone mineral density; LUSC cis rs12137294 0.794 rs1172160 chr1:205207015 G/A cg00857998 chr1:205179979 DSTYK 0.4 5.77 0.3 1.77e-8 Red cell distribution width; LUSC cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs17401966 0.518 rs10864453 chr1:10407169 T/G cg19773385 chr1:10388646 KIF1B -0.36 -6.24 -0.32 1.31e-9 Hepatocellular carcinoma; LUSC cis rs11190604 1.000 rs4919465 chr10:102221703 C/T cg07080220 chr10:102295463 HIF1AN 0.65 8.72 0.43 1.34e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6696846 0.630 rs11240373 chr1:205135600 A/C cg21545522 chr1:205238299 TMCC2 0.49 8.86 0.44 4.69e-17 Red blood cell count; LUSC cis rs7580658 0.857 rs17015199 chr2:128094053 A/G cg09760422 chr2:128146352 NA -0.3 -6.4 -0.33 5.19e-10 Protein C levels; LUSC trans rs1908814 0.516 rs13275143 chr8:11796990 T/A cg15556689 chr8:8085844 FLJ10661 0.56 8.36 0.42 1.76e-15 Neuroticism; LUSC cis rs72634258 0.554 rs12745962 chr1:7919825 C/T cg00042356 chr1:8021962 PARK7 0.6 7.0 0.36 1.41e-11 Inflammatory bowel disease; LUSC cis rs826838 0.616 rs2387921 chr12:38624767 T/C cg26384229 chr12:38710491 ALG10B -0.56 -8.45 -0.42 8.99e-16 Heart rate; LUSC cis rs2273669 0.667 rs9688496 chr6:109364825 G/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.17 0.32 2.03e-9 Height; LUSC cis rs7804356 1.000 rs73067437 chr7:26850313 T/C cg03456212 chr7:26904342 SKAP2 -0.54 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09763514 chr7:2298050 SNX8 -0.41 -5.95 -0.31 6.84e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs56804039 1.000 rs6986470 chr8:8381430 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -7.01 -0.36 1.29e-11 Cervical cancer; LUSC cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg22676075 chr6:135203613 NA 0.58 9.32 0.45 1.61e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs17253792 0.822 rs75763956 chr14:56071176 A/G cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.9e-12 Putamen volume; LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg11645453 chr3:52864694 ITIH4 0.36 8.63 0.43 2.5e-16 Bipolar disorder; LUSC cis rs1003719 0.715 rs2835646 chr21:38546574 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg12165864 chr7:66369176 NA -0.53 -7.2 -0.37 4.13e-12 Corneal structure; LUSC cis rs9389248 0.500 rs116273677 chr6:135339135 A/C cg22676075 chr6:135203613 NA 0.48 7.47 0.38 6.97e-13 High light scatter reticulocyte percentage of red cells; LUSC cis rs965513 1.000 rs965513 chr9:100556109 A/G cg13688889 chr9:100608707 NA -0.54 -8.16 -0.41 6.68e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg01802117 chr1:53393560 SCP2 0.36 5.84 0.3 1.23e-8 Monocyte count; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg18404041 chr3:52824283 ITIH1 -0.56 -10.63 -0.5 6.41e-23 Intelligence (multi-trait analysis); LUSC cis rs12122100 0.545 rs1984615 chr1:146506206 G/A cg02487331 chr1:146550467 NA -0.43 -7.51 -0.38 5.28e-13 HIV-1 control; LUSC cis rs908922 0.676 rs525960 chr1:152497866 T/A cg20991723 chr1:152506922 NA 0.53 9.87 0.48 2.41e-20 Hair morphology; LUSC cis rs6700896 0.931 rs11208717 chr1:66158994 T/C cg04111102 chr1:66153794 NA 0.34 7.42 0.38 1e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg26380479 chr7:97908229 NA -0.28 -6.26 -0.32 1.16e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs877282 0.755 rs1769242 chr10:787896 T/C cg22713356 chr15:30763199 NA 0.9 12.97 0.58 1.87e-31 Uric acid levels; LUSC cis rs240768 1.000 rs33988845 chr6:100964158 G/A cg12253828 chr6:101329408 ASCC3 0.93 6.4 0.33 5.13e-10 Economic and political preferences (immigration/crime); LUSC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.11 0.36 6.98e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10927875 0.597 rs61782184 chr1:16150976 G/A cg22431228 chr1:16359049 CLCNKA 0.34 6.41 0.33 5.1e-10 Dilated cardiomyopathy; LUSC cis rs7809950 0.906 rs2395907 chr7:107253304 A/G cg23024343 chr7:107201750 COG5 0.56 8.55 0.42 4.45e-16 Coronary artery disease; LUSC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg05802129 chr4:122689817 NA -0.37 -6.69 -0.34 9.46e-11 Type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03315476 chr1:40915606 ZNF643 0.44 6.23 0.32 1.4e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs782590 0.837 rs782573 chr2:55912961 T/C cg18811423 chr2:55921094 PNPT1 0.9 16.03 0.66 2.76e-43 Metabolic syndrome; LUSC cis rs1113500 0.548 rs17020971 chr1:108655288 C/A cg06207961 chr1:108661230 NA 0.34 5.82 0.3 1.4e-8 Growth-regulated protein alpha levels; LUSC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg23711669 chr6:146136114 FBXO30 -0.73 -12.87 -0.58 4.55e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg19077165 chr18:44547161 KATNAL2 -0.45 -6.74 -0.35 7e-11 Personality dimensions; LUSC cis rs1371867 0.775 rs3020183 chr8:101233297 A/T cg00191853 chr8:101177733 SPAG1 0.41 6.64 0.34 1.3100000000000001e-10 Atrioventricular conduction; LUSC cis rs208520 0.690 rs207108 chr6:66794096 T/C cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs7607369 0.791 rs72965151 chr2:219344165 G/T cg02176678 chr2:219576539 TTLL4 -0.74 -14.04 -0.61 1.64e-35 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs2625529 0.586 rs11639282 chr15:72435260 G/A cg16672083 chr15:72433130 SENP8 0.5 8.27 0.41 3.29e-15 Red blood cell count; LUSC cis rs4722585 0.533 rs2049843 chr7:26196963 G/A cg07876897 chr7:26191696 NFE2L3 0.46 6.85 0.35 3.65e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg07212818 chr11:638076 DRD4 -0.42 -7.15 -0.36 5.65e-12 Systemic lupus erythematosus; LUSC cis rs738321 0.725 rs5756926 chr22:38542613 T/C cg25457927 chr22:38595422 NA -0.42 -8.01 -0.4 1.93e-14 Breast cancer; LUSC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg23583168 chr7:148888333 NA -0.8 -12.88 -0.58 4.22e-31 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg09835421 chr16:68378352 PRMT7 -0.55 -6.16 -0.32 2.09e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg08859206 chr1:53392774 SCP2 -0.68 -12.93 -0.58 2.87e-31 Monocyte count; LUSC cis rs9300255 0.544 rs1727309 chr12:123658258 A/G cg13010344 chr12:123464640 ARL6IP4 -0.54 -6.51 -0.34 2.82e-10 Neutrophil percentage of white cells; LUSC cis rs34779708 0.733 rs11597184 chr10:35397396 G/A cg04310649 chr10:35416472 CREM -0.42 -6.47 -0.33 3.4e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs12145833 0.596 rs12123491 chr1:243297924 C/G cg01826367 chr1:224180288 NA 0.69 6.44 0.33 4.06e-10 Obesity (early onset extreme); LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg23131131 chr22:24373011 LOC391322 -0.41 -5.99 -0.31 5.46e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg13319975 chr6:146136371 FBXO30 0.48 7.25 0.37 2.88e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg13334819 chr7:99746414 C7orf59 -0.44 -5.87 -0.31 1.05e-8 Coronary artery disease; LUSC cis rs1113500 0.932 rs1343205 chr1:108597873 C/G cg11967332 chr1:108735228 SLC25A24 0.38 5.72 0.3 2.41e-8 Growth-regulated protein alpha levels; LUSC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg09367891 chr1:107599246 PRMT6 0.51 7.85 0.39 5.71e-14 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.4 -8.18 -0.41 5.91e-15 Autism spectrum disorder or schizophrenia; LUSC cis rs72772090 0.539 rs72773923 chr5:96117579 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.55 -0.34 2.18e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg05484376 chr2:27715224 FNDC4 0.3 5.67 0.3 3.01e-8 Total body bone mineral density; LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.57 -0.5 1.04e-22 Alzheimer's disease; LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg09877947 chr5:131593287 PDLIM4 0.43 6.7 0.34 8.76e-11 Breast cancer; LUSC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg22467129 chr15:76604101 ETFA -0.44 -6.88 -0.35 3.01e-11 Blood metabolite levels; LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg00684032 chr4:1343700 KIAA1530 0.37 6.53 0.34 2.38e-10 Obesity-related traits; LUSC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg15556689 chr8:8085844 FLJ10661 -0.56 -8.55 -0.42 4.52e-16 Joint mobility (Beighton score); LUSC cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg26384229 chr12:38710491 ALG10B 0.9 15.64 0.65 9.37e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.75 0.3 2.01e-8 Tonsillectomy; LUSC cis rs9534288 0.699 rs4280137 chr13:46664008 G/A cg15192986 chr13:46630673 CPB2 -0.72 -10.54 -0.5 1.28e-22 Blood protein levels; LUSC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg12927641 chr6:109611667 NA -0.43 -7.5 -0.38 5.89e-13 Reticulocyte fraction of red cells; LUSC cis rs12579753 0.917 rs76240969 chr12:82195236 C/A cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs9398803 0.865 rs9375439 chr6:126758540 C/G cg19875578 chr6:126661172 C6orf173 0.41 6.09 0.32 3.18e-9 Male-pattern baldness; LUSC cis rs595982 0.527 rs73061656 chr19:49372355 G/A cg15549821 chr19:49342101 PLEKHA4 -0.58 -7.63 -0.39 2.43e-13 Red cell distribution width; LUSC cis rs2797160 0.967 rs1739355 chr6:126018114 A/G cg05901451 chr6:126070800 HEY2 0.57 8.61 0.43 2.85e-16 Endometrial cancer; LUSC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg23711669 chr6:146136114 FBXO30 0.88 16.07 0.66 1.92e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.818 rs684305 chr1:153006242 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs8078723 1.000 rs2227336 chr17:38174855 T/G cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.9 -0.35 2.6e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg16145915 chr7:1198662 ZFAND2A -0.72 -14.8 -0.63 1.82e-38 Longevity;Endometriosis; LUSC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.88 11.15 0.52 9.46e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg13114125 chr14:105738426 BRF1 -0.91 -15.96 -0.66 5.14e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg19318889 chr4:1322082 MAEA 0.47 7.6 0.38 2.95e-13 Obesity-related traits; LUSC cis rs75804782 0.521 rs72993044 chr2:239397949 C/T cg18131467 chr2:239335373 ASB1 -0.67 -6.17 -0.32 2e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs710216 0.957 rs12041787 chr1:43432275 G/C cg22176566 chr1:43424700 SLC2A1 0.48 6.01 0.31 4.79e-9 Red cell distribution width; LUSC cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg15103426 chr22:29168792 CCDC117 0.45 5.87 0.31 1.06e-8 Lymphocyte counts; LUSC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg06697600 chr4:7070879 GRPEL1 -0.4 -6.61 -0.34 1.49e-10 Monocyte percentage of white cells; LUSC cis rs10203711 0.966 rs10187949 chr2:239558408 T/C cg14580085 chr2:239553406 NA 0.4 6.8 0.35 4.78e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9905704 0.633 rs917016 chr17:56454156 C/T cg19466818 chr17:56409534 MIR142 0.32 5.91 0.31 8.36e-9 Testicular germ cell tumor; LUSC cis rs9486719 0.843 rs2499789 chr6:96844510 T/C cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg18132916 chr6:79620363 NA -0.41 -6.2 -0.32 1.63e-9 Intelligence (multi-trait analysis); LUSC cis rs7336332 0.598 rs1885988 chr13:28010262 C/T cg22138327 chr13:27999177 GTF3A -0.76 -9.87 -0.48 2.58e-20 Weight; LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC cis rs13315871 1.000 rs13060489 chr3:58339287 G/A cg12435725 chr3:58293450 RPP14 -0.75 -7.83 -0.39 6.63e-14 Cholesterol, total; LUSC cis rs921665 0.831 rs11690724 chr2:3188333 T/G cg16434511 chr2:3151078 NA -0.63 -6.78 -0.35 5.3e-11 World class endurance athleticism; LUSC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.06e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1568889 1.000 rs66857704 chr11:28212346 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 8.63 0.43 2.62e-16 Bipolar disorder; LUSC cis rs7100689 0.646 rs6585946 chr10:82118292 G/T cg00277334 chr10:82204260 NA -0.53 -7.8 -0.39 7.93e-14 Post bronchodilator FEV1; LUSC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg11608241 chr8:8085544 FLJ10661 0.43 6.32 0.33 8.46e-10 Systolic blood pressure; LUSC cis rs7246657 0.943 rs1559229 chr19:37876197 T/C cg23950597 chr19:37808831 NA -0.63 -7.63 -0.39 2.43e-13 Coronary artery calcification; LUSC cis rs3087591 0.960 rs9896041 chr17:29571326 C/G cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.19 -0.41 5.62e-15 Hip circumference; LUSC cis rs12618769 0.597 rs72821907 chr2:99085296 A/G cg10123293 chr2:99228465 UNC50 0.45 7.38 0.37 1.25e-12 Bipolar disorder; LUSC trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg15556689 chr8:8085844 FLJ10661 -0.61 -9.03 -0.44 1.44e-17 Triglycerides; LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg01879757 chr17:41196368 BRCA1 -0.45 -6.99 -0.36 1.54e-11 Menopause (age at onset); LUSC cis rs10911251 0.546 rs3359 chr1:183112041 G/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.69e-23 Colorectal cancer; LUSC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg25072359 chr17:41440525 NA 0.63 9.22 0.45 3.35e-18 Menopause (age at onset); LUSC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg22823121 chr1:150693482 HORMAD1 0.55 7.94 0.4 3.09e-14 Melanoma; LUSC cis rs2742417 0.603 rs2673055 chr3:45772772 G/A cg10512202 chr3:45649293 LIMD1 0.36 5.94 0.31 7.3e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9462027 0.675 rs34657938 chr6:34801631 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.03 -0.31 4.26e-9 Systemic lupus erythematosus; LUSC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg27572855 chr1:25598939 RHD -0.43 -7.6 -0.38 3.1e-13 Erythrocyte sedimentation rate; LUSC cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg16989719 chr2:238392110 NA -0.42 -7.14 -0.36 5.97e-12 Prostate cancer; LUSC cis rs4631830 0.863 rs3101227 chr10:51520203 C/A cg10326726 chr10:51549505 MSMB -0.33 -5.66 -0.3 3.32e-8 Prostate-specific antigen levels; LUSC cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg24642439 chr20:33292090 TP53INP2 -0.49 -7.29 -0.37 2.27e-12 Glomerular filtration rate (creatinine); LUSC cis rs6580649 0.941 rs11613485 chr12:48462455 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs7590720 1.000 rs934156 chr2:216901482 C/T cg12620499 chr2:216877984 MREG -0.87 -12.96 -0.58 2.05e-31 Alcohol dependence; LUSC cis rs79387448 0.745 rs1523196 chr2:103163700 T/G cg09003973 chr2:102972529 NA 0.89 8.62 0.43 2.69e-16 Gut microbiota (bacterial taxa); LUSC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg25019033 chr10:957182 NA -0.53 -6.1 -0.32 2.91e-9 Eosinophil percentage of granulocytes; LUSC cis rs9611565 0.592 rs80477 chr22:42001183 C/T cg03806693 chr22:41940476 POLR3H 0.91 12.73 0.57 1.53e-30 Vitiligo; LUSC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg20608306 chr11:116969690 SIK3 0.39 6.51 0.34 2.69e-10 Blood protein levels; LUSC cis rs500891 0.533 rs6454331 chr6:84175632 G/A cg08257003 chr6:84140564 ME1 0.33 8.11 0.41 9.92e-15 Platelet-derived growth factor BB levels; LUSC cis rs977987 0.931 rs8057084 chr16:75492706 G/T cg04384234 chr16:75411784 CFDP1 0.45 7.28 0.37 2.45e-12 Dupuytren's disease; LUSC cis rs908922 0.676 rs6658925 chr1:152482801 C/T cg20991723 chr1:152506922 NA -0.48 -8.86 -0.44 4.99e-17 Hair morphology; LUSC cis rs6076065 0.723 rs2144381 chr20:23369940 C/T cg11657817 chr20:23433608 CST11 0.42 7.99 0.4 2.19e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs68170813 0.559 rs76646886 chr7:107034328 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.26 -0.45 2.51e-18 Coronary artery disease; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.42e-17 Prudent dietary pattern; LUSC cis rs2072499 0.898 rs2758609 chr1:156202868 G/A cg24450063 chr1:156163899 SLC25A44 1.06 20.26 0.74 4.47e-60 Testicular germ cell tumor; LUSC trans rs1908814 0.516 rs13275143 chr8:11796990 T/A cg27411982 chr8:10470053 RP1L1 0.42 6.49 0.33 3.02e-10 Neuroticism; LUSC cis rs9398803 0.605 rs112166936 chr6:126733140 A/C cg19875578 chr6:126661172 C6orf173 0.43 6.26 0.32 1.15e-9 Male-pattern baldness; LUSC cis rs1595825 1.000 rs73058821 chr2:198864597 A/G cg00982548 chr2:198649783 BOLL -0.51 -6.4 -0.33 5.26e-10 Ulcerative colitis; LUSC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg12365402 chr11:9010492 NRIP3 0.46 8.95 0.44 2.46e-17 Tonsillectomy; LUSC cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22857025 chr5:266934 NA -1.16 -14.37 -0.62 8.82e-37 Breast cancer; LUSC cis rs7917772 0.582 rs10786680 chr10:104317192 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.69 11.15 0.52 9.51e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs72781680 1.000 rs72796328 chr2:24141343 A/G cg08917208 chr2:24149416 ATAD2B 1.01 10.61 0.5 7.29e-23 Lymphocyte counts; LUSC cis rs8114671 0.967 rs6142320 chr20:33788193 A/G cg07148914 chr20:33460835 GGT7 -0.44 -6.52 -0.34 2.66e-10 Height; LUSC cis rs3736594 0.513 rs62141278 chr2:27768381 C/T cg27432699 chr2:27873401 GPN1 0.67 8.86 0.44 4.69e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05918473 chr13:32885580 ZAR1L 0.48 5.99 0.31 5.42e-9 Bipolar disorder and schizophrenia; LUSC cis rs17125944 0.505 rs74642116 chr14:53213507 A/G cg13660082 chr14:53194042 PSMC6 -0.78 -6.82 -0.35 4.38e-11 Alzheimer's disease (late onset); LUSC cis rs10489202 1.000 rs7538581 chr1:167979347 A/G cg24449463 chr1:168025552 DCAF6 -0.58 -7.31 -0.37 1.98e-12 Schizophrenia; LUSC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg19257562 chr1:2043853 PRKCZ 0.31 6.12 0.32 2.65e-9 Height; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg01842473 chr11:617407 IRF7;MUPCDH -0.69 -10.09 -0.48 4.37e-21 Systemic lupus erythematosus; LUSC cis rs11105298 0.891 rs10777185 chr12:89921275 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.28 -0.37 2.35e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2692947 0.644 rs1724125 chr2:96831355 G/A cg22654517 chr2:96458247 NA 0.32 5.84 0.3 1.21e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg05658215 chr7:157211628 NA 0.31 5.74 0.3 2.15e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs3806843 1.000 rs10038174 chr5:140210616 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.85 -0.3 1.17e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9611519 0.929 rs73174657 chr22:41434158 G/A cg03806693 chr22:41940476 POLR3H -0.51 -6.93 -0.35 2.17e-11 Neuroticism; LUSC cis rs9467773 0.935 rs1056668 chr6:26510605 C/T cg11502198 chr6:26597334 ABT1 0.54 8.01 0.4 1.93e-14 Intelligence (multi-trait analysis); LUSC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg21862992 chr11:68658383 NA 0.51 7.75 0.39 1.09e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg20476274 chr7:133979776 SLC35B4 0.84 15.5 0.65 3.46e-41 Mean platelet volume; LUSC cis rs9309473 0.660 rs79370894 chr2:73683515 C/A cg20560298 chr2:73613845 ALMS1 -0.55 -6.51 -0.34 2.69e-10 Metabolite levels; LUSC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.79e-10 Schizophrenia; LUSC trans rs1997103 0.911 rs9642575 chr7:55399090 C/T cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs5769765 0.671 rs138833 chr22:50178917 A/G cg02269571 chr22:50332266 NA -0.44 -6.89 -0.35 2.74e-11 Schizophrenia; LUSC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg11871910 chr12:69753446 YEATS4 0.91 17.0 0.68 3.9e-47 Cerebrospinal fluid biomarker levels; LUSC cis rs2290416 0.892 rs34178175 chr8:144664687 G/A cg14809332 chr8:144654887 C8orf73 0.46 5.95 0.31 6.77e-9 Attention deficit hyperactivity disorder; LUSC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg15352829 chr14:105391018 PLD4 -0.43 -8.99 -0.44 1.9e-17 Rheumatoid arthritis; LUSC cis rs11018904 0.906 rs7925507 chr11:89940146 T/C cg26834418 chr11:89957033 CHORDC1 -0.51 -6.08 -0.32 3.28e-9 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg18132916 chr6:79620363 NA -0.39 -6.02 -0.31 4.69e-9 Intelligence (multi-trait analysis); LUSC cis rs1801251 1.000 rs2592102 chr2:233726772 G/T cg25237894 chr2:233734115 C2orf82 -0.36 -6.63 -0.34 1.35e-10 Coronary artery disease; LUSC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.2 0.32 1.69e-9 Multiple sclerosis; LUSC cis rs9503598 0.636 rs6596977 chr6:3466254 G/A cg00476032 chr6:3446245 SLC22A23 0.3 5.99 0.31 5.5e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg03647317 chr4:187891568 NA -0.34 -5.75 -0.3 1.96e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs12136530 0.774 rs58952060 chr1:19774582 G/A cg01832549 chr1:19774989 CAPZB -0.32 -5.94 -0.31 7.33e-9 Lead levels in blood; LUSC cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg27446573 chr6:127587934 RNF146 0.67 10.12 0.48 3.54e-21 Breast cancer; LUSC trans rs11039798 0.764 rs12277213 chr11:48782176 G/A cg15704280 chr7:45808275 SEPT13 0.77 7.41 0.38 1.01e-12 Axial length; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08081407 chr3:57583693 ARF4 -0.36 -6.09 -0.32 3.09e-9 Electrocardiographic conduction measures; LUSC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg14019146 chr3:50243930 SLC38A3 0.29 6.42 0.33 4.63e-10 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg15556689 chr8:8085844 FLJ10661 -0.57 -8.97 -0.44 2.14e-17 Neuroticism; LUSC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg11608241 chr8:8085544 FLJ10661 0.4 5.8 0.3 1.58e-8 Mood instability; LUSC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg27535305 chr1:53392650 SCP2 0.33 5.98 0.31 5.85e-9 Monocyte count; LUSC cis rs17401966 0.894 rs11587309 chr1:10446596 G/T cg19773385 chr1:10388646 KIF1B -0.58 -9.39 -0.46 9.87e-19 Hepatocellular carcinoma; LUSC cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.37 0.33 6.28e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2279817 0.735 rs12075624 chr1:17991573 A/G cg21791023 chr1:18019539 ARHGEF10L -0.47 -6.15 -0.32 2.27e-9 Neuroticism; LUSC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg13628971 chr7:2884303 GNA12 0.43 6.56 0.34 2.02e-10 Height; LUSC trans rs208520 1.000 rs208536 chr6:66963440 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.34 -0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs67072384 1.000 rs56693670 chr11:72445143 G/T cg04827223 chr11:72435913 ARAP1 -0.82 -7.76 -0.39 1.04e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs11098499 0.863 rs6534139 chr4:120449456 A/G cg24375607 chr4:120327624 NA -0.77 -11.08 -0.52 1.7e-24 Corneal astigmatism; LUSC cis rs12210905 0.925 rs72838236 chr6:26971202 C/T cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg06544989 chr22:39130855 UNC84B 0.39 7.03 0.36 1.15e-11 Menopause (age at onset); LUSC cis rs12579753 0.871 rs10862362 chr12:82199383 T/G cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg08798685 chr6:27730294 NA -0.66 -6.01 -0.31 4.77e-9 Depression; LUSC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg01765077 chr12:122356316 WDR66 0.53 7.66 0.39 2.03e-13 Mean corpuscular volume; LUSC cis rs2573652 1.000 rs12440866 chr15:100517010 G/A cg09918751 chr15:100517450 ADAMTS17 -0.46 -8.67 -0.43 1.84e-16 Height; LUSC cis rs13401104 0.740 rs12475284 chr2:237118586 A/C cg19324714 chr2:237145437 ASB18 0.43 5.73 0.3 2.25e-8 Educational attainment; LUSC trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.28 -0.32 1.03e-9 Myopia (pathological); LUSC cis rs34658409 1 rs34658409 chr8:42433985 TC/T cg09913449 chr8:42400586 C8orf40 0.5 8.26 0.41 3.35e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs9611565 0.729 rs169362 chr22:41827589 G/C cg03806693 chr22:41940476 POLR3H 0.85 12.3 0.56 6.36e-29 Vitiligo; LUSC trans rs514406 0.929 rs11206035 chr1:53323571 T/C cg24643429 chr1:3562429 WDR8 0.33 6.05 0.31 3.88e-9 Monocyte count; LUSC cis rs367943 1.000 rs348956 chr5:112821464 C/T cg12552261 chr5:112820674 MCC 0.44 7.11 0.36 7.19e-12 Type 2 diabetes; LUSC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg07777115 chr5:623756 CEP72 -0.45 -5.65 -0.3 3.48e-8 Obesity-related traits; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg02475777 chr4:1388615 CRIPAK 0.62 9.3 0.45 1.88e-18 Longevity; LUSC cis rs1865721 1.000 rs72977890 chr18:73198776 C/A cg26385618 chr18:73139727 C18orf62 -0.47 -7.9 -0.4 3.94e-14 Intelligence; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.8 0.39 7.91e-14 Lymphocyte counts; LUSC cis rs12368653 0.591 rs1038914 chr12:58011066 G/A cg12615879 chr12:58013172 SLC26A10 -0.42 -10.45 -0.5 2.67e-22 Multiple sclerosis; LUSC cis rs9640161 0.789 rs10248490 chr7:150051418 C/G cg10018233 chr7:150070692 REPIN1 0.37 6.51 0.34 2.78e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs1577917 0.958 rs10806337 chr6:86474249 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.95 -0.44 2.42e-17 Response to antipsychotic treatment; LUSC trans rs61931739 0.963 rs12307606 chr12:34016365 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.09 -0.32 3.06e-9 Morning vs. evening chronotype; LUSC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg06740227 chr12:86229804 RASSF9 0.44 6.96 0.36 1.84e-11 Major depressive disorder; LUSC trans rs877282 0.583 rs10904562 chr10:819058 T/C cg13042288 chr15:90349979 ANPEP -0.43 -6.39 -0.33 5.44e-10 Uric acid levels; LUSC cis rs7819412 0.659 rs4073948 chr8:10772644 A/T cg21775007 chr8:11205619 TDH -0.45 -6.12 -0.32 2.6e-9 Triglycerides; LUSC cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg16576597 chr16:28551801 NUPR1 0.33 6.72 0.35 7.96e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7106204 0.513 rs7131144 chr11:24249486 A/G ch.11.24196551F chr11:24239977 NA 0.9 9.58 0.46 2.36e-19 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11779988 0.545 rs208759 chr8:17807929 G/C cg01800426 chr8:17659068 MTUS1 -0.47 -5.91 -0.31 8.31e-9 Breast cancer; LUSC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -6.61 -0.34 1.52e-10 Developmental language disorder (linguistic errors); LUSC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg21856205 chr7:94953877 PON1 -0.38 -6.18 -0.32 1.82e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs11112613 0.713 rs73184084 chr12:105952615 T/A cg03607813 chr12:105948248 NA 0.78 11.63 0.54 1.74e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg20135002 chr11:47629003 NA -0.49 -7.49 -0.38 6.26e-13 Subjective well-being; LUSC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg27398817 chr8:82754497 SNX16 -0.51 -6.79 -0.35 5.01e-11 Diastolic blood pressure; LUSC trans rs3733585 0.781 rs13103690 chr4:9972778 T/G cg26043149 chr18:55253948 FECH -0.46 -7.14 -0.36 5.88e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9378688 0.654 rs2505657 chr6:2331510 T/C cg12303981 chr6:2244766 GMDS -0.44 -6.12 -0.32 2.64e-9 Caudate nucleus volume; LUSC cis rs780094 0.606 rs6729709 chr2:27583156 G/A cg22903471 chr2:27725779 GCKR -0.42 -7.2 -0.37 3.91e-12 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs981844 0.683 rs1037647 chr4:154737991 A/G cg14289246 chr4:154710475 SFRP2 -0.44 -6.13 -0.32 2.46e-9 Response to statins (LDL cholesterol change); LUSC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg21862992 chr11:68658383 NA 0.5 7.9 0.4 3.97e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg06697600 chr4:7070879 GRPEL1 0.45 6.43 0.33 4.31e-10 Monocyte percentage of white cells; LUSC cis rs1372520 0.873 rs2583990 chr4:90771499 A/G cg15133208 chr4:90757351 SNCA -0.53 -8.21 -0.41 4.76e-15 Neuroticism; LUSC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg04414720 chr1:150670196 GOLPH3L 0.53 8.53 0.42 5e-16 Tonsillectomy; LUSC cis rs5758659 1.000 rs5758677 chr22:42643039 A/C cg05082376 chr22:42548792 NA -0.4 -6.62 -0.34 1.45e-10 Cognitive function; LUSC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg20476274 chr7:133979776 SLC35B4 0.81 14.5 0.62 2.68e-37 Mean platelet volume; LUSC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg22800045 chr5:56110881 MAP3K1 0.77 9.42 0.46 7.46e-19 Initial pursuit acceleration; LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg27535305 chr1:53392650 SCP2 0.36 6.8 0.35 4.92e-11 Monocyte count; LUSC cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg22782873 chr19:19639568 YJEFN3 -0.5 -6.43 -0.33 4.31e-10 Bipolar disorder; LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg08742575 chr21:47604166 C21orf56 0.46 6.92 0.35 2.27e-11 Testicular germ cell tumor; LUSC cis rs11864453 0.826 rs9941087 chr16:72118324 G/A cg23815491 chr16:72088622 HP 0.36 6.37 0.33 6.29e-10 Fibrinogen levels; LUSC cis rs73206853 0.841 rs7956963 chr12:110947783 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.06 0.36 9.69e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2933343 0.729 rs1680786 chr3:128644840 T/C cg11901034 chr3:128598214 ACAD9 -0.41 -6.47 -0.33 3.54e-10 IgG glycosylation; LUSC cis rs9875589 0.957 rs13077668 chr3:13929756 A/G cg19554555 chr3:13937349 NA -0.49 -7.69 -0.39 1.71e-13 Ovarian reserve; LUSC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg03709012 chr19:19516395 GATAD2A 0.78 12.05 0.55 5.37e-28 Tonsillectomy; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg20295408 chr7:1910781 MAD1L1 -0.54 -7.84 -0.39 5.98e-14 Bipolar disorder and schizophrenia; LUSC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg03433033 chr1:76189801 ACADM -0.79 -13.09 -0.58 7.18e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg15744005 chr10:104629667 AS3MT -0.33 -6.07 -0.32 3.51e-9 Arsenic metabolism; LUSC cis rs2233152 0.656 rs10405633 chr19:41291703 G/A cg21869046 chr19:41225005 ITPKC 0.44 6.15 0.32 2.16e-9 Kawasaki disease; LUSC cis rs66887589 0.934 rs4834792 chr4:120555696 T/A cg09307838 chr4:120376055 NA -0.49 -7.4 -0.38 1.13e-12 Diastolic blood pressure; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14631462 chr10:31607925 ZEB1;LOC220930 -0.39 -6.32 -0.33 8.16e-10 Triglycerides; LUSC cis rs9326248 0.861 rs4938352 chr11:117027481 G/A cg11861562 chr11:117069780 TAGLN 0.35 5.65 0.3 3.4e-8 Blood protein levels; LUSC cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg05535760 chr7:792225 HEATR2 0.78 9.14 0.45 6.04e-18 Cerebrospinal P-tau181p levels; LUSC cis rs7586879 0.521 rs7597332 chr2:25075675 A/G cg01884057 chr2:25150051 NA 0.4 8.99 0.44 1.9e-17 Body mass index; LUSC trans rs11098499 0.909 rs28571712 chr4:120375980 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg26354017 chr1:205819088 PM20D1 0.95 19.8 0.73 2.85e-58 Menarche (age at onset); LUSC cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg09184832 chr6:79620586 NA -0.44 -7.1 -0.36 7.62e-12 Intelligence (multi-trait analysis); LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg05552183 chr6:42928497 GNMT 0.55 9.43 0.46 7.36e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg05973401 chr12:123451056 ABCB9 0.62 9.24 0.45 2.94e-18 Platelet count; LUSC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg14196790 chr5:131705035 SLC22A5 0.37 6.23 0.32 1.39e-9 Blood metabolite levels; LUSC cis rs4631830 0.737 rs7071471 chr10:51503335 C/T cg16070123 chr10:51489643 NA 0.53 8.34 0.41 2.04e-15 Prostate-specific antigen levels; LUSC cis rs1023500 0.529 rs133375 chr22:42466509 C/G cg05082376 chr22:42548792 NA -0.43 -6.41 -0.33 5.03e-10 Schizophrenia; LUSC cis rs9560113 0.960 rs9560101 chr13:112173798 G/A cg14154082 chr13:112174009 NA 0.38 7.95 0.4 2.97e-14 Menarche (age at onset); LUSC cis rs11209185 0.545 rs1926284 chr1:68446291 T/C cg22082780 chr1:68452167 NA 0.44 7.31 0.37 2.05e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs929596 0.556 rs10168416 chr2:234597087 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.78 -0.39 9.19e-14 Total bilirubin levels in HIV-1 infection; LUSC cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.81 -0.51 1.5e-23 Alzheimer's disease (late onset); LUSC cis rs3768617 0.706 rs4129858 chr1:183004334 A/G ch.1.3577855R chr1:183094577 LAMC1 0.59 8.41 0.42 1.18e-15 Fuchs's corneal dystrophy; LUSC cis rs11792861 0.926 rs7856626 chr9:111775502 C/G cg13535736 chr9:111863775 C9orf5 -0.43 -6.96 -0.36 1.76e-11 Menarche (age at onset); LUSC cis rs10392 0.543 rs6028200 chr20:37540615 C/T cg27552599 chr20:37590471 DHX35 0.42 6.77 0.35 5.65e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg09998033 chr7:158218633 PTPRN2 -0.6 -9.74 -0.47 6.8e-20 Obesity-related traits; LUSC cis rs977987 0.778 rs4888412 chr16:75443196 A/G cg03315344 chr16:75512273 CHST6 0.48 8.98 0.44 2.08e-17 Dupuytren's disease; LUSC cis rs2050392 0.630 rs303427 chr10:30739780 G/A cg25182066 chr10:30743637 MAP3K8 -0.39 -5.92 -0.31 8.02e-9 Inflammatory bowel disease; LUSC cis rs7424096 0.527 rs4670637 chr2:37164857 T/G cg14987922 chr2:37194071 STRN 0.63 9.64 0.47 1.47e-19 High light scatter reticulocyte percentage of red cells; LUSC cis rs3770081 1.000 rs79152960 chr2:86290661 A/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.51 0.34 2.8e-10 Schizophrenia; LUSC cis rs317689 0.718 rs160827 chr12:69770147 G/A cg20891283 chr12:69753455 YEATS4 0.59 8.08 0.4 1.22e-14 Response to diuretic therapy; LUSC cis rs3096299 0.754 rs3102382 chr16:89409742 C/G cg06640241 chr16:89574553 SPG7 0.49 7.0 0.36 1.44e-11 Multiple myeloma (IgH translocation); LUSC cis rs9354308 0.933 rs55672811 chr6:66571730 G/A cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.28 -0.37 2.44e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9309473 0.898 rs6546852 chr2:73833431 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.63 -0.34 1.37e-10 Metabolite levels; LUSC trans rs7980799 0.682 rs1351682 chr12:33598775 G/A cg26384229 chr12:38710491 ALG10B -0.58 -8.85 -0.44 5.37e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg08045932 chr20:61659980 NA 0.58 10.07 0.48 5.3e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.78 0.39 8.95e-14 Electroencephalogram traits; LUSC cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg19077165 chr18:44547161 KATNAL2 0.46 6.76 0.35 6.36e-11 Personality dimensions; LUSC trans rs7824557 0.603 rs2249804 chr8:11215617 C/G cg08975724 chr8:8085496 FLJ10661 0.5 7.08 0.36 8.66e-12 Retinal vascular caliber; LUSC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC cis rs1775715 0.737 rs2778672 chr10:32122419 T/C cg03015672 chr10:32216066 ARHGAP12 0.33 5.85 0.3 1.18e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1348850 0.632 rs13009207 chr2:178501632 A/G cg22681709 chr2:178499509 PDE11A -0.57 -11.54 -0.53 3.85e-26 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9916302 0.653 rs4239223 chr17:37717004 T/C cg07936489 chr17:37558343 FBXL20 -0.84 -10.53 -0.5 1.44e-22 Glomerular filtration rate (creatinine); LUSC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg04871131 chr7:94954202 PON1 -0.37 -5.97 -0.31 6.14e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs644799 0.544 rs1150360 chr11:95512060 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.67 9.83 0.47 3.46e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs73200209 0.744 rs11614867 chr12:116658916 A/C cg01776926 chr12:116560359 MED13L -0.49 -6.05 -0.31 3.97e-9 Total body bone mineral density; LUSC cis rs595982 0.527 rs73061658 chr19:49372376 G/C cg15549821 chr19:49342101 PLEKHA4 -0.58 -7.63 -0.39 2.43e-13 Red cell distribution width; LUSC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.52 -0.34 2.53e-10 High light scatter reticulocyte count; LUSC cis rs8060686 0.668 rs12448991 chr16:68218894 T/A cg09835421 chr16:68378352 PRMT7 -0.54 -6.04 -0.31 4.2e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg10018233 chr7:150070692 REPIN1 0.4 7.23 0.37 3.3e-12 Blood protein levels;Circulating chemerin levels; LUSC trans rs17685 0.702 rs6960598 chr7:75772991 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 18.97 0.72 5.86e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg14092988 chr3:52407081 DNAH1 0.32 6.22 0.32 1.51e-9 Bipolar disorder; LUSC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.37 -0.49 5.14e-22 Gut microbiome composition (summer); LUSC cis rs4853012 0.887 rs7570950 chr2:74338942 T/C cg05890377 chr2:74357713 NA 0.68 11.96 0.55 1.1e-27 Gestational age at birth (maternal effect); LUSC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs10504073 0.647 rs7817571 chr8:50003218 T/C cg00325661 chr8:49890786 NA 0.62 10.3 0.49 8.96e-22 Blood metabolite ratios; LUSC cis rs7592578 1.000 rs7592578 chr2:191439591 T/G cg10560079 chr2:191398806 TMEM194B 0.71 9.02 0.44 1.54e-17 Diastolic blood pressure; LUSC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg24531977 chr5:56204891 C5orf35 -0.61 -9.04 -0.44 1.26e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs6565180 1.000 rs11863150 chr16:30385503 C/T cg17640201 chr16:30407289 ZNF48 0.92 17.06 0.68 2.34e-47 Tonsillectomy; LUSC cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg00530320 chr1:46809349 NSUN4 0.55 8.49 0.42 6.91e-16 Menopause (age at onset); LUSC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg07636037 chr3:49044803 WDR6 1.05 19.18 0.72 8.03e-56 Parkinson's disease; LUSC cis rs921968 0.565 rs7595901 chr2:219606931 A/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.08 -0.48 5.06e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs12493885 0.585 rs696869 chr3:153630341 A/C cg17054900 chr3:154042577 DHX36 -0.59 -6.01 -0.31 4.73e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4242434 0.857 rs11777808 chr8:22462755 A/C cg03733263 chr8:22462867 KIAA1967 0.99 18.5 0.71 4.35e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC trans rs6076960 0.652 rs3852945 chr20:6254118 T/C cg21095983 chr6:86352623 SYNCRIP 0.51 8.08 0.4 1.19e-14 Smooth-surface caries; LUSC cis rs6489882 0.807 rs10774677 chr12:113362421 G/A cg20102336 chr12:113376681 OAS3 -0.41 -5.88 -0.31 9.9e-9 Chronic lymphocytic leukemia; LUSC cis rs7215564 0.822 rs2340769 chr17:78755271 C/T cg23238734 chr17:78661607 RPTOR -0.51 -6.14 -0.32 2.31e-9 Myopia (pathological); LUSC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg00745463 chr17:30367425 LRRC37B -0.85 -9.92 -0.48 1.72e-20 Hip circumference adjusted for BMI; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg11494091 chr17:61959527 GH2 0.65 13.92 0.61 4.91e-35 Prudent dietary pattern; LUSC cis rs17286411 0.701 rs4788812 chr16:71625467 A/G cg10085824 chr16:71800315 AP1G1 0.37 5.97 0.31 5.94e-9 Blood protein levels; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.52 8.16 0.41 6.87e-15 Bipolar disorder; LUSC cis rs4363385 0.553 rs61813181 chr1:152942177 T/C cg00922841 chr1:152955080 SPRR1A -0.36 -6.06 -0.31 3.63e-9 Inflammatory skin disease; LUSC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10493773 1.000 rs3767163 chr1:86121895 T/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.42 -0.46 7.59e-19 Urate levels in overweight individuals; LUSC cis rs2742234 0.504 rs10899780 chr10:43725796 T/C cg02780029 chr10:43622663 RET 0.34 5.7 0.3 2.58e-8 Hirschsprung disease; LUSC cis rs2067615 0.579 rs4385986 chr12:107133775 C/T cg15890332 chr12:107067104 RFX4 0.33 6.01 0.31 4.92e-9 Heart rate; LUSC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg08847533 chr14:75593920 NEK9 -0.81 -13.05 -0.58 9.79e-32 Height; LUSC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg04352962 chr1:209979756 IRF6 0.58 6.3 0.33 9.3e-10 Cleft lip with or without cleft palate; LUSC cis rs62400317 0.826 rs11970496 chr6:45125833 A/G cg20913747 chr6:44695427 NA -0.47 -7.55 -0.38 4.27e-13 Total body bone mineral density; LUSC cis rs7927771 0.826 rs7925389 chr11:47466790 A/T cg18512352 chr11:47633146 NA -0.47 -9.48 -0.46 4.78e-19 Subjective well-being; LUSC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg07636037 chr3:49044803 WDR6 1.04 16.32 0.67 1.96e-44 Parkinson's disease; LUSC trans rs7615952 0.546 rs11711150 chr3:125315663 C/T cg07211511 chr3:129823064 LOC729375 -0.57 -6.3 -0.33 9.48e-10 Blood pressure (smoking interaction); LUSC cis rs478304 0.654 rs7115734 chr11:65458964 G/A cg27068330 chr11:65405492 SIPA1 -0.75 -10.31 -0.49 7.88e-22 Acne (severe); LUSC cis rs2760061 0.819 rs3094913 chr1:228206980 T/C cg04850211 chr1:228464232 OBSCN -0.32 -5.75 -0.3 1.98e-8 Diastolic blood pressure; LUSC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg11645453 chr3:52864694 ITIH4 0.28 6.32 0.33 8.2e-10 Bipolar disorder; LUSC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg13298116 chr11:62369859 EML3;MTA2 0.59 9.58 0.46 2.25e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg02038168 chr22:39784481 NA 0.5 8.34 0.42 1.94e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg24110177 chr3:50126178 RBM5 0.63 10.93 0.51 5.59e-24 Body mass index; LUSC cis rs308403 0.568 rs13102440 chr4:123664919 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.79 10.18 0.49 2.16e-21 Blood protein levels; LUSC cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg15103426 chr22:29168792 CCDC117 0.45 5.76 0.3 1.87e-8 Lymphocyte counts; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg10802521 chr3:52805072 NEK4 -0.49 -7.76 -0.39 1.02e-13 Electroencephalogram traits; LUSC cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg00677455 chr12:58241039 CTDSP2 0.54 7.74 0.39 1.21e-13 Intelligence (multi-trait analysis); LUSC cis rs13315871 1.000 rs35621601 chr3:58323174 A/G cg12435725 chr3:58293450 RPP14 -0.72 -7.15 -0.36 5.35e-12 Cholesterol, total; LUSC trans rs1268789 0.545 rs753751 chr4:79373254 A/G cg06112894 chr8:141469983 TRAPPC9 0.22 6.05 0.31 3.96e-9 Hair shape;Hair morphology; LUSC cis rs1577917 1.000 rs16876529 chr6:86591202 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.41 -6.01 -0.31 4.86e-9 Response to antipsychotic treatment; LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg08736216 chr1:53307985 ZYG11A -0.3 -6.28 -0.33 1.05e-9 Monocyte count; LUSC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.5 -0.34 2.94e-10 Alzheimer's disease (late onset); LUSC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg02773041 chr1:40204384 PPIE 0.54 8.26 0.41 3.35e-15 Blood protein levels; LUSC cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.6 -0.57 4.72e-30 Chronic sinus infection; LUSC cis rs11577318 0.579 rs12131370 chr1:26698430 G/A cg00852783 chr1:26633632 UBXN11 -0.54 -7.45 -0.38 7.88e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs9638182 0.560 rs67644909 chr7:72995954 C/T cg07452164 chr7:72993570 TBL2 0.45 6.33 0.33 7.79e-10 Triglycerides; LUSC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs1395 0.744 rs11126929 chr2:27472027 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.45 -7.14 -0.36 5.87e-12 Blood metabolite levels; LUSC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg06808227 chr14:105710500 BRF1 -0.73 -11.76 -0.54 5.74e-27 Mean platelet volume;Platelet distribution width; LUSC cis rs4843747 0.671 rs13334603 chr16:88116016 T/C cg17633681 chr16:88106987 BANP 0.5 9.29 0.45 2.01e-18 Menopause (age at onset); LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.96 0.51 4.51e-24 Menopause (age at onset); LUSC cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg16586182 chr3:47516702 SCAP -0.56 -9.08 -0.44 9.89e-18 Colorectal cancer; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg23131131 chr22:24373011 LOC391322 -0.5 -7.13 -0.36 6.42e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11992162 0.591 rs34123222 chr8:11795349 C/T cg21775007 chr8:11205619 TDH -0.44 -5.99 -0.31 5.39e-9 Monocyte count; LUSC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg15445000 chr17:37608096 MED1 0.4 6.79 0.35 5.09e-11 Glomerular filtration rate (creatinine); LUSC cis rs4919087 0.923 rs11189038 chr10:98974765 A/T cg25902810 chr10:99078978 FRAT1 0.46 6.55 0.34 2.24e-10 Monocyte count; LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.9 -0.31 9.08e-9 Platelet count; LUSC cis rs6012564 0.963 rs6125551 chr20:47720386 C/G cg03212862 chr20:47662828 CSE1L 0.46 6.58 0.34 1.85e-10 Anger; LUSC trans rs35491132 1 rs35491132 chr6:27527227 GT/G cg06606381 chr12:133084897 FBRSL1 -0.92 -8.91 -0.44 3.3e-17 Urinary tract infection frequency; LUSC cis rs7937682 1.000 rs505372 chr11:111507189 A/C cg09085632 chr11:111637200 PPP2R1B -1.1 -16.79 -0.68 2.73e-46 Primary sclerosing cholangitis; LUSC cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 7.61 0.38 2.92e-13 Colorectal cancer; LUSC cis rs66887589 0.934 rs41464847 chr4:120532401 A/G cg24375607 chr4:120327624 NA -0.46 -7.43 -0.38 8.93e-13 Diastolic blood pressure; LUSC cis rs11098499 0.909 rs28884220 chr4:120307211 A/G cg09307838 chr4:120376055 NA 0.77 11.23 0.52 4.66e-25 Corneal astigmatism; LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg16647868 chr5:131706066 SLC22A5 0.38 5.97 0.31 6.22e-9 Breast cancer; LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.58 0.42 3.71e-16 Bipolar disorder; LUSC cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs7614311 0.636 rs73117059 chr3:63916028 A/G cg22134162 chr3:63841271 THOC7 -0.49 -6.2 -0.32 1.71e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs826838 1.000 rs826888 chr12:39104719 C/G cg13010199 chr12:38710504 ALG10B -0.65 -11.12 -0.52 1.19e-24 Heart rate; LUSC cis rs9300255 0.602 rs1727294 chr12:123616514 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.09 -0.32 3.13e-9 Neutrophil percentage of white cells; LUSC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg09835421 chr16:68378352 PRMT7 -0.55 -6.16 -0.32 2.09e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg17948913 chr5:572064 NA 0.36 6.08 0.32 3.32e-9 Obesity-related traits; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg21782813 chr7:2030301 MAD1L1 0.37 6.03 0.31 4.44e-9 Bipolar disorder and schizophrenia; LUSC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg02788857 chr8:22132959 PIWIL2 0.39 7.48 0.38 6.82e-13 Hypertriglyceridemia; LUSC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg16240275 chr20:61666158 NCRNA00029 0.42 9.25 0.45 2.82e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6714788 0.565 rs7599083 chr2:100658077 G/A cg07810366 chr2:100720526 AFF3 -0.39 -6.22 -0.32 1.51e-9 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg08045932 chr20:61659980 NA 0.59 10.33 0.49 6.74e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg23711669 chr6:146136114 FBXO30 -0.91 -17.36 -0.69 1.44e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs1577917 0.958 rs12195776 chr6:86488599 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.86 -0.44 5.01e-17 Response to antipsychotic treatment; LUSC cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.38 0.69 1.15e-48 Chronic sinus infection; LUSC cis rs5758511 0.689 rs55906806 chr22:42644471 C/T cg00645731 chr22:42541494 CYP2D7P1 0.55 8.74 0.43 1.18e-16 Birth weight; LUSC trans rs4724055 0.557 rs2118679 chr7:41636787 T/C cg23476065 chr7:151106043 WDR86 0.71 6.1 0.32 2.95e-9 Non-substance related behavioral disinhibition; LUSC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg12288994 chr5:1860383 NA 0.28 6.16 0.32 2.12e-9 Cardiovascular disease risk factors; LUSC cis rs8054556 0.647 rs11863174 chr16:30019375 A/C cg06326092 chr16:30034487 C16orf92 0.23 5.68 0.3 3.01e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg11084020 chr7:27779567 TAX1BP1 0.32 6.32 0.33 8.26e-10 Tuberculosis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09857708 chr16:66586376 CKLF 0.46 6.29 0.33 1e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg19628046 chr18:33552617 C18orf21 0.51 6.11 0.32 2.73e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs17095355 0.605 rs3740140 chr10:111632937 T/G cg00817464 chr10:111662876 XPNPEP1 -0.55 -6.51 -0.34 2.81e-10 Biliary atresia; LUSC trans rs10432489 0.708 rs12328545 chr2:181771545 T/A cg04744134 chr19:8408128 KANK3 0.83 6.27 0.32 1.13e-9 QT interval; LUSC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.75 -0.3 1.97e-8 Tonsillectomy; LUSC cis rs2028299 1.000 rs1371135 chr15:90391270 T/C cg23731826 chr15:90371692 NA 0.29 5.65 0.3 3.45e-8 Type 2 diabetes; LUSC cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11644478 chr21:40555479 PSMG1 0.95 18.75 0.72 4.32e-54 Cognitive function; LUSC cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg07606381 chr6:8435919 SLC35B3 0.72 12.12 0.55 2.87e-28 Motion sickness; LUSC cis rs11971779 0.680 rs4732373 chr7:139086535 T/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg09699651 chr6:150184138 LRP11 0.38 5.72 0.3 2.42e-8 Lung cancer; LUSC cis rs61931739 0.500 rs34061369 chr12:34519283 C/T cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.57e-10 Morning vs. evening chronotype; LUSC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg24675056 chr1:15929824 NA 0.45 7.76 0.39 1.03e-13 Systolic blood pressure; LUSC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg23172400 chr8:95962367 TP53INP1 -0.4 -8.09 -0.4 1.12e-14 Type 2 diabetes; LUSC cis rs7089973 0.624 rs1359080 chr10:116582419 C/A cg03647239 chr10:116582469 FAM160B1 0.44 7.02 0.36 1.24e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg13535736 chr9:111863775 C9orf5 -0.41 -6.56 -0.34 2.03e-10 Menarche (age at onset); LUSC cis rs7739264 0.564 rs760794 chr6:19790560 C/T cg02404759 chr6:19790362 NA -0.44 -7.02 -0.36 1.22e-11 Endometriosis; LUSC cis rs6121246 0.609 rs2377317 chr20:30402502 A/G cg13852791 chr20:30311386 BCL2L1 -0.91 -13.97 -0.61 3.14e-35 Mean corpuscular hemoglobin; LUSC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg06238570 chr21:40685208 BRWD1 -0.57 -8.76 -0.43 9.9900000000000006e-17 Menarche (age at onset); LUSC cis rs13064411 0.597 rs2291905 chr3:113010466 C/T cg18753928 chr3:113234510 CCDC52 -0.36 -5.79 -0.3 1.61e-8 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg00310523 chr12:86230176 RASSF9 -0.51 -9.67 -0.47 1.2e-19 Major depressive disorder; LUSC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg06028605 chr16:24865363 SLC5A11 -0.38 -6.15 -0.32 2.18e-9 Intelligence (multi-trait analysis); LUSC cis rs847577 0.550 rs12670686 chr7:97708397 A/G cg21770322 chr7:97807741 LMTK2 0.5 8.81 0.43 7.01e-17 Breast cancer; LUSC trans rs7824557 0.593 rs11774673 chr8:11191537 T/C cg06636001 chr8:8085503 FLJ10661 0.43 6.26 0.32 1.17e-9 Retinal vascular caliber; LUSC cis rs12579753 0.879 rs11115010 chr12:82165895 G/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.39 -0.33 5.47e-10 Resting heart rate; LUSC cis rs12594515 1.000 rs11854554 chr15:45994546 C/G cg01629716 chr15:45996671 NA 0.39 5.87 0.31 1.08e-8 Waist circumference;Weight; LUSC cis rs662064 0.962 rs622623 chr1:10555257 C/T cg17425144 chr1:10567563 PEX14 0.36 5.76 0.3 1.89e-8 Asthma; LUSC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg15212455 chr7:39170539 POU6F2 0.6 9.87 0.48 2.41e-20 IgG glycosylation; LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg04518342 chr5:131593106 PDLIM4 0.44 7.61 0.38 2.87e-13 Breast cancer; LUSC cis rs9512730 0.527 rs11619784 chr13:27999643 A/G cg08193333 chr13:27998609 GTF3A 0.46 5.77 0.3 1.76e-8 Schizophrenia; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.21 0.37 3.79e-12 Alzheimer's disease; LUSC cis rs977987 0.806 rs1109342 chr16:75445675 A/G cg03315344 chr16:75512273 CHST6 -0.47 -8.76 -0.43 9.76e-17 Dupuytren's disease; LUSC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg22903657 chr4:1355424 KIAA1530 -0.36 -5.94 -0.31 6.96e-9 Longevity; LUSC cis rs694739 0.796 rs479777 chr11:64107477 A/G cg23796481 chr11:64053134 BAD;GPR137 0.54 8.42 0.42 1.1e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.754 rs1511025 chr4:120240238 T/C cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs2074585 0.517 rs11638010 chr15:91079920 A/G cg10434728 chr15:90938212 IQGAP1 -0.36 -6.85 -0.35 3.64e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs977987 0.843 rs60730309 chr16:75431769 C/G cg04384234 chr16:75411784 CFDP1 -0.44 -7.2 -0.37 4.03e-12 Dupuytren's disease; LUSC cis rs2952156 0.959 rs1495102 chr17:37832093 T/C cg20243544 chr17:37824526 PNMT 0.49 6.88 0.35 2.98e-11 Asthma; LUSC cis rs12594515 1.000 rs11855562 chr15:45995659 C/T cg01629716 chr15:45996671 NA 0.39 5.87 0.31 1.08e-8 Waist circumference;Weight; LUSC cis rs2019216 0.521 rs12449447 chr17:21888786 C/T cg22648282 chr17:21454238 C17orf51 -0.52 -7.58 -0.38 3.37e-13 Pelvic organ prolapse; LUSC cis rs9467773 1.000 rs6930120 chr6:26555484 A/G cg05738196 chr6:26577821 NA 0.83 16.11 0.66 1.29e-43 Intelligence (multi-trait analysis); LUSC cis rs4891159 0.790 rs683306 chr18:74112473 C/G cg24786174 chr18:74118243 ZNF516 -0.82 -15.35 -0.64 1.32e-40 Longevity; LUSC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg05855489 chr10:104503620 C10orf26 0.58 9.2 0.45 4.02e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg06784218 chr1:46089804 CCDC17 0.53 10.22 0.49 1.67e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs826838 1.000 rs10875717 chr12:38911174 T/C cg13010199 chr12:38710504 ALG10B 0.68 11.24 0.52 4.28e-25 Heart rate; LUSC cis rs10203711 1.000 rs4994756 chr2:239567125 T/C cg14580085 chr2:239553406 NA 0.41 6.99 0.36 1.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg27432699 chr2:27873401 GPN1 -0.59 -8.84 -0.44 5.51e-17 Total body bone mineral density; LUSC cis rs9303401 0.614 rs35057477 chr17:57097064 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.08 0.58 7.59e-32 Cognitive test performance; LUSC cis rs921968 0.565 rs6436071 chr2:219598041 A/T cg02176678 chr2:219576539 TTLL4 -0.57 -9.99 -0.48 1.02e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg09184832 chr6:79620586 NA -0.44 -7.01 -0.36 1.34e-11 Intelligence (multi-trait analysis); LUSC cis rs722599 0.715 rs11851433 chr14:75339450 C/T cg08847533 chr14:75593920 NEK9 0.45 6.38 0.33 5.83e-10 IgG glycosylation; LUSC cis rs7267979 1.000 rs6050632 chr20:25432601 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6500395 1.000 rs2354578 chr16:48593298 T/C cg04672837 chr16:48644449 N4BP1 0.43 6.34 0.33 7.56e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg08564027 chr20:61660810 NA 0.9 17.01 0.68 3.71e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs56283067 0.671 rs1028608 chr6:44681721 C/T cg20913747 chr6:44695427 NA -0.43 -7.16 -0.36 5.05e-12 Total body bone mineral density; LUSC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11644478 chr21:40555479 PSMG1 0.92 18.06 0.7 2.35e-51 Cognitive function; LUSC cis rs6558174 0.930 rs1038311 chr8:22489247 T/C cg03733263 chr8:22462867 KIAA1967 0.48 6.45 0.33 3.81e-10 Breast cancer; LUSC cis rs9886651 0.776 rs4733560 chr8:128779001 G/A cg07795030 chr8:128802207 NA -0.36 -6.61 -0.34 1.54e-10 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg06112835 chr11:68658793 MRPL21 0.52 7.95 0.4 2.84e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg27494647 chr7:150038898 RARRES2 0.56 8.22 0.41 4.61e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs2455601 0.608 rs1368017 chr11:8867070 A/C cg12365402 chr11:9010492 NRIP3 -0.36 -5.75 -0.3 2.04e-8 Schizophrenia; LUSC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg26647111 chr11:31128758 NA -0.43 -6.12 -0.32 2.58e-9 Red blood cell count; LUSC cis rs1801251 0.929 rs12694917 chr2:233707611 C/T cg08000102 chr2:233561755 GIGYF2 -0.71 -11.74 -0.54 6.86e-27 Coronary artery disease; LUSC trans rs9329221 0.710 rs11779205 chr8:10260100 C/T cg06636001 chr8:8085503 FLJ10661 0.52 7.05 0.36 1.05e-11 Neuroticism; LUSC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg24060327 chr5:131705240 SLC22A5 -0.52 -8.62 -0.43 2.72e-16 Breast cancer; LUSC cis rs727505 0.721 rs67607629 chr7:124765867 C/T cg23710748 chr7:124431027 NA -0.39 -6.96 -0.36 1.76e-11 Lewy body disease; LUSC cis rs9925964 0.933 rs2303223 chr16:31075175 G/A cg02466173 chr16:30829666 NA 0.36 6.49 0.33 3.09e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs968567 0.539 rs174556 chr11:61580635 C/T cg19610905 chr11:61596333 FADS2 -0.54 -7.88 -0.4 4.52e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC trans rs6952808 0.608 rs58120505 chr7:2029867 T/C cg04565464 chr8:145669602 NFKBIL2 0.43 7.14 0.36 5.92e-12 Bipolar disorder and schizophrenia; LUSC cis rs7605827 0.930 rs6431704 chr2:15592061 G/T cg19274914 chr2:15703543 NA 0.47 8.96 0.44 2.36e-17 Educational attainment (years of education); LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg05564831 chr3:52568323 NT5DC2 0.36 6.51 0.34 2.69e-10 Electroencephalogram traits; LUSC cis rs11779988 0.528 rs208029 chr8:17840987 A/C cg01800426 chr8:17659068 MTUS1 -0.55 -6.89 -0.35 2.81e-11 Breast cancer; LUSC cis rs9948 0.655 rs17119564 chr2:97384728 G/A cg01990225 chr2:97406019 LMAN2L -1.05 -7.21 -0.37 3.67e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg01802117 chr1:53393560 SCP2 0.4 6.6 0.34 1.64e-10 Monocyte count; LUSC cis rs9300255 0.602 rs1727294 chr12:123616514 A/G cg13010344 chr12:123464640 ARL6IP4 -0.44 -6.07 -0.32 3.49e-9 Neutrophil percentage of white cells; LUSC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg05347473 chr6:146136440 FBXO30 0.64 10.89 0.51 7.72e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs9814567 0.762 rs13079012 chr3:134247706 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 11.75 0.54 6.72e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg06784218 chr1:46089804 CCDC17 0.55 11.18 0.52 7.53e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs920590 0.684 rs3899017 chr8:19669198 A/T cg03894339 chr8:19674705 INTS10 0.58 7.84 0.39 5.95e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg11645453 chr3:52864694 ITIH4 0.37 8.7 0.43 1.52e-16 Bipolar disorder; LUSC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg22834771 chr12:69754056 YEATS4 -0.55 -8.28 -0.41 3.04e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg21724239 chr8:58056113 NA 0.85 8.52 0.42 5.38e-16 Developmental language disorder (linguistic errors); LUSC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg26818010 chr10:134567672 INPP5A -0.86 -11.07 -0.52 1.83e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg14092988 chr3:52407081 DNAH1 0.31 6.03 0.31 4.33e-9 Bipolar disorder; LUSC cis rs9325144 0.624 rs7312879 chr12:39150752 G/A cg26384229 chr12:38710491 ALG10B -0.6 -9.4 -0.46 9.02e-19 Morning vs. evening chronotype; LUSC cis rs1371867 0.846 rs1616833 chr8:101271821 C/T cg06636551 chr8:101224915 SPAG1 0.38 7.02 0.36 1.23e-11 Atrioventricular conduction; LUSC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg14552801 chr7:65878734 NA -0.43 -6.23 -0.32 1.43e-9 Aortic root size; LUSC cis rs13631 0.894 rs7856589 chr9:140003921 A/G cg14395844 chr9:139980277 LOC100289341;MAN1B1 -0.42 -6.48 -0.33 3.22e-10 Cerebrospinal fluid biomarker levels; LUSC cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg17063962 chr7:91808500 NA 0.56 8.69 0.43 1.63e-16 Breast cancer; LUSC cis rs9393777 0.920 rs72839445 chr6:27249686 G/A cg09904177 chr6:26538194 HMGN4 -0.74 -5.65 -0.3 3.43e-8 Intelligence (multi-trait analysis); LUSC cis rs9815354 0.812 rs59138513 chr3:41908611 T/G cg03022575 chr3:42003672 ULK4 0.83 8.67 0.43 1.88e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs11098499 0.532 rs4504231 chr4:120586891 G/A cg24375607 chr4:120327624 NA 0.74 11.22 0.52 5.36e-25 Corneal astigmatism; LUSC trans rs208520 1.000 rs12192261 chr6:66985268 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.57 0.34 1.98e-10 Lung cancer; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg09177884 chr7:1199841 ZFAND2A -0.59 -8.33 -0.41 2.14e-15 Longevity;Endometriosis; LUSC cis rs926938 0.563 rs360652 chr1:115445478 C/T cg01522456 chr1:115632236 TSPAN2 -0.41 -6.28 -0.32 1.05e-9 Autism; LUSC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg24675056 chr1:15929824 NA 0.44 7.77 0.39 1.01e-13 Systolic blood pressure; LUSC cis rs34734847 0.842 rs556001 chr12:121152967 A/G cg27246729 chr12:121163418 ACADS 0.42 6.62 0.34 1.4e-10 Mean corpuscular volume; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg23145915 chr12:58146234 CDK4 -0.4 -6.04 -0.31 4e-9 Hepatitis; LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg27284194 chr4:1044797 NA -0.36 -5.81 -0.3 1.47e-8 Obesity-related traits; LUSC cis rs7605827 0.930 rs2058867 chr2:15520153 T/C cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.82e-17 Educational attainment (years of education); LUSC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg07936489 chr17:37558343 FBXL20 0.71 10.02 0.48 7.57e-21 Glomerular filtration rate (creatinine); LUSC cis rs6733011 0.518 rs12992214 chr2:99466337 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.66 -0.34 1.15e-10 Bipolar disorder; LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.32 -0.41 2.32e-15 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7527798 0.592 rs6684643 chr1:207846242 A/T cg09232269 chr1:207846808 CR1L -0.29 -6.16 -0.32 2.11e-9 Erythrocyte sedimentation rate; LUSC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg14830002 chr1:247616686 OR2B11 0.5 6.91 0.35 2.45e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg24399712 chr22:39784796 NA -0.65 -12.1 -0.55 3.5e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs10266483 0.881 rs636242 chr7:63744755 A/T cg24201672 chr7:64023550 ZNF680 -0.43 -5.66 -0.3 3.2e-8 Response to statin therapy; LUSC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg27398817 chr8:82754497 SNX16 0.59 7.4 0.38 1.15e-12 Diastolic blood pressure; LUSC trans rs7819412 0.540 rs2409726 chr8:11043138 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.12 -0.36 6.69e-12 Triglycerides; LUSC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg25767906 chr1:53392781 SCP2 0.4 6.91 0.35 2.48e-11 Monocyte count; LUSC cis rs4409675 0.556 rs2064710 chr1:28231154 G/A cg23691781 chr1:28212827 C1orf38 0.31 7.48 0.38 6.53e-13 Corneal astigmatism; LUSC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg22029157 chr1:209979665 IRF6 0.76 9.85 0.47 2.97e-20 Cleft lip with or without cleft palate; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg24503407 chr1:205819492 PM20D1 -0.54 -8.48 -0.42 7.63e-16 Menarche (age at onset); LUSC cis rs9814567 0.712 rs9838889 chr3:134332311 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.62 -0.57 4.01e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs826838 0.935 rs980571 chr12:39127532 C/G cg13010199 chr12:38710504 ALG10B -0.6 -10.25 -0.49 1.29e-21 Heart rate; LUSC cis rs1670533 1.000 rs13119276 chr4:1051574 T/C cg27284194 chr4:1044797 NA 0.57 8.42 0.42 1.12e-15 Recombination rate (females); LUSC cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg17173187 chr15:85201210 NMB 0.48 9.16 0.45 5.35e-18 Schizophrenia; LUSC cis rs72634258 0.945 rs67717282 chr1:8041290 C/T cg26816564 chr1:7831052 VAMP3 0.47 5.98 0.31 5.67e-9 Inflammatory bowel disease; LUSC cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg03517284 chr6:25882590 NA -0.52 -9.7 -0.47 9.32e-20 Blood metabolite levels; LUSC cis rs710216 0.843 rs710220 chr1:43415346 G/T cg03128534 chr1:43423976 SLC2A1 0.48 6.21 0.32 1.56e-9 Red cell distribution width; LUSC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg22467129 chr15:76604101 ETFA -0.46 -7.24 -0.37 3.21e-12 Blood metabolite levels; LUSC cis rs2760061 0.819 rs708120 chr1:228207651 G/C cg02753203 chr1:228287806 NA 0.71 12.53 0.57 8.91e-30 Diastolic blood pressure; LUSC cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg06784218 chr1:46089804 CCDC17 0.48 9.49 0.46 4.5e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg24829409 chr8:58192753 C8orf71 -0.61 -7.49 -0.38 6.09e-13 Developmental language disorder (linguistic errors); LUSC cis rs2235642 0.821 rs2281236 chr16:1603576 G/A cg09025071 chr16:1593152 IFT140;TMEM204 0.3 6.63 0.34 1.37e-10 Coronary artery disease; LUSC cis rs6599077 0.802 rs17075542 chr3:40128458 A/G cg13683864 chr3:40499215 RPL14 0.54 7.45 0.38 7.88e-13 Sleep-related phenotypes; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg18904891 chr8:8559673 CLDN23 0.59 8.15 0.41 7.49e-15 Obesity-related traits; LUSC trans rs1555543 0.538 rs7416802 chr1:96909292 G/C cg10631902 chr5:14652156 NA -0.49 -6.74 -0.35 6.84e-11 Body mass index; LUSC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg16447950 chr5:562315 NA -0.57 -7.04 -0.36 1.12e-11 Obesity-related traits; LUSC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.83 0.63 1.37e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg06850241 chr22:41845214 NA 0.31 5.73 0.3 2.23e-8 Vitiligo; LUSC cis rs10791323 0.569 rs10736608 chr11:133740048 C/T cg00579200 chr11:133705235 NA -0.39 -5.96 -0.31 6.35e-9 Childhood ear infection; LUSC cis rs950169 0.922 rs12915832 chr15:85111457 C/T cg12863693 chr15:85201151 NMB 0.33 6.83 0.35 4.06e-11 Schizophrenia; LUSC cis rs55675132 0.596 rs1627205 chr1:115643166 A/G cg01522456 chr1:115632236 TSPAN2 0.45 6.28 0.32 1.05e-9 Schizophrenia; LUSC cis rs7246657 0.943 rs10404602 chr19:37825633 A/T cg23950597 chr19:37808831 NA -0.65 -7.78 -0.39 8.97e-14 Coronary artery calcification; LUSC cis rs11098499 0.779 rs10011097 chr4:120310359 T/G cg09307838 chr4:120376055 NA 0.77 11.15 0.52 9.05e-25 Corneal astigmatism; LUSC cis rs9322817 0.691 rs2034821 chr6:105219537 C/T cg02098413 chr6:105308735 HACE1 -0.28 -5.7 -0.3 2.59e-8 Thyroid stimulating hormone; LUSC cis rs10992471 0.580 rs1535756 chr9:95202032 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -7.89 -0.4 4.36e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.2 -0.37 3.94e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs3847687 1.000 rs11061303 chr12:131526322 A/G cg25772418 chr12:131519998 GPR133 -0.26 -5.76 -0.3 1.93e-8 Longevity; LUSC cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg01689657 chr7:91764605 CYP51A1 0.33 5.97 0.31 6.12e-9 Breast cancer; LUSC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg21951975 chr1:209979733 IRF6 0.55 6.99 0.36 1.53e-11 Cleft lip with or without cleft palate; LUSC cis rs73206853 0.764 rs16940935 chr12:111107470 A/G cg12870014 chr12:110450643 ANKRD13A 0.7 7.43 0.38 9.41e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg26384229 chr12:38710491 ALG10B 0.93 15.83 0.65 1.69e-42 Bladder cancer; LUSC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.87 0.4 5.13e-14 Parkinson's disease; LUSC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg20135002 chr11:47629003 NA -0.48 -7.55 -0.38 4.19e-13 Subjective well-being; LUSC cis rs10170310 0.938 rs11680891 chr2:139264454 T/G cg10095539 chr2:139258744 SPOPL 0.34 5.92 0.31 8.17e-9 Response to antipsychotic treatment; LUSC cis rs11166629 1.000 rs894349 chr8:135638055 T/C cg27224718 chr8:135614730 ZFAT 0.67 11.29 0.53 3.03e-25 Smoking quantity; LUSC cis rs16854884 0.657 rs13086088 chr3:143723942 G/A cg06585982 chr3:143692056 C3orf58 0.5 8.1 0.41 1.06e-14 Economic and political preferences (feminism/equality); LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.79 -0.39 8.27e-14 Lymphocyte counts; LUSC cis rs1577917 0.652 rs75593931 chr6:86719539 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.79 -0.43 8.21e-17 Response to antipsychotic treatment; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg26354017 chr1:205819088 PM20D1 0.86 15.57 0.65 1.7e-41 Menarche (age at onset); LUSC cis rs4363385 0.818 rs11205164 chr1:152986023 A/T cg00922841 chr1:152955080 SPRR1A -0.42 -7.09 -0.36 7.87e-12 Inflammatory skin disease; LUSC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg13770153 chr20:60521292 NA 0.73 9.83 0.47 3.36e-20 Body mass index; LUSC cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg20503657 chr10:835505 NA 0.92 12.57 0.57 6.3e-30 Eosinophil percentage of granulocytes; LUSC cis rs6736093 0.933 rs4848238 chr2:112754720 A/C cg12686935 chr2:112915763 FBLN7 -0.37 -6.06 -0.31 3.73e-9 Coronary artery disease; LUSC cis rs1348850 0.914 rs12612857 chr2:178467144 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 6.29 0.33 9.9e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs5769765 0.671 rs138833 chr22:50178917 A/G cg26441486 chr22:50317300 CRELD2 0.42 6.67 0.34 1.09e-10 Schizophrenia; LUSC cis rs1215050 0.740 rs700739 chr4:99022546 A/G cg05340658 chr4:99064831 C4orf37 -0.46 -7.31 -0.37 1.97e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs614226 1.000 rs12310837 chr12:120880572 C/T cg21053147 chr12:120880522 NA -0.53 -6.5 -0.33 2.96e-10 Type 1 diabetes nephropathy; LUSC cis rs7100689 0.646 rs6585967 chr10:82139791 A/G cg01528321 chr10:82214614 TSPAN14 -0.88 -13.39 -0.59 5.17e-33 Post bronchodilator FEV1; LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg04622731 chr7:157956161 PTPRN2 -0.48 -8.54 -0.42 4.73e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.87 0.6 7.37e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg18402987 chr7:1209562 NA 0.71 7.88 0.4 4.57e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06858599 chr2:70520566 SNRPG -0.45 -6.7 -0.34 8.82e-11 Electrocardiographic conduction measures; LUSC cis rs6500395 1.000 rs1386040 chr16:48631207 A/G cg04672837 chr16:48644449 N4BP1 0.49 7.34 0.37 1.65e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7223966 1.000 rs9903897 chr17:61716705 T/A cg05941027 chr17:61774174 LIMD2 0.23 6.37 0.33 6.34e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.33 0.33 7.87e-10 Hip circumference adjusted for BMI; LUSC cis rs500891 0.525 rs12198419 chr6:84105865 A/T cg08257003 chr6:84140564 ME1 0.34 8.35 0.42 1.83e-15 Platelet-derived growth factor BB levels; LUSC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg10253484 chr15:75165896 SCAMP2 -0.49 -7.29 -0.37 2.33e-12 Breast cancer; LUSC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.69 -0.34 9.56e-11 Lung cancer; LUSC cis rs523522 0.962 rs655530 chr12:121022275 T/C cg27279351 chr12:120934652 DYNLL1 0.66 8.97 0.44 2.22e-17 High light scatter reticulocyte count; LUSC trans rs1973993 0.691 rs1980683 chr1:96890379 A/G cg10631902 chr5:14652156 NA 0.6 10.73 0.51 2.8e-23 Weight; LUSC cis rs4792901 0.765 rs12600416 chr17:41546558 A/G cg22562494 chr17:41607896 ETV4 -0.34 -6.35 -0.33 7.12e-10 Dupuytren's disease; LUSC cis rs72781680 0.898 rs72780121 chr2:23995918 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.79 -0.39 8.63e-14 Blood metabolite levels; LUSC cis rs7712401 0.601 rs398142 chr5:122345576 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.25 -0.45 2.68e-18 Mean platelet volume; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg02576345 chr2:37311098 CCDC75;HEATR5B -0.42 -6.04 -0.31 4.08e-9 Hepatitis; LUSC cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg27247225 chr6:26970382 C6orf41 -0.46 -5.76 -0.3 1.91e-8 Intelligence (multi-trait analysis); LUSC cis rs12681288 0.550 rs73176529 chr8:962283 G/C cg15309053 chr8:964076 NA 0.4 7.97 0.4 2.55e-14 Schizophrenia; LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.02 -0.58 1.23e-31 Platelet count; LUSC cis rs3820928 0.874 rs4234063 chr2:227828335 A/T cg11843606 chr2:227700838 RHBDD1 0.54 7.91 0.4 3.85e-14 Pulmonary function; LUSC cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg05283184 chr6:79620031 NA -0.57 -12.2 -0.56 1.41e-28 Intelligence (multi-trait analysis); LUSC trans rs7618501 0.633 rs12485600 chr3:50025530 A/G cg21659725 chr3:3221576 CRBN 0.63 10.37 0.49 5.03e-22 Intelligence (multi-trait analysis); LUSC cis rs7824557 0.564 rs13260727 chr8:11232860 A/G cg21775007 chr8:11205619 TDH 0.6 9.2 0.45 3.93e-18 Retinal vascular caliber; LUSC trans rs6502050 0.529 rs35585236 chr17:80116641 T/C cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.41e-10 Life satisfaction; LUSC trans rs6450176 0.633 rs10054623 chr5:53343821 A/G cg12559925 chr2:235863365 SH3BP4 0.36 5.95 0.31 6.64e-9 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; LUSC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs17401966 0.931 rs4846213 chr1:10399178 A/G cg19773385 chr1:10388646 KIF1B -0.57 -9.79 -0.47 4.78e-20 Hepatocellular carcinoma; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg16405210 chr4:1374714 KIAA1530 -0.58 -9.57 -0.46 2.46e-19 Longevity; LUSC cis rs2540226 0.874 rs11124691 chr2:39967768 T/A cg23576258 chr2:39999331 THUMPD2 0.35 6.01 0.31 4.76e-9 Personality dimensions; LUSC cis rs861020 1.000 rs595918 chr1:209966843 A/G cg05527609 chr1:210001259 C1orf107 0.9 11.69 0.54 1.04e-26 Orofacial clefts; LUSC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg14061069 chr19:46274453 DMPK -0.49 -8.39 -0.42 1.37e-15 Coronary artery disease; LUSC cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.22 0.88 3.18e-111 Chronic sinus infection; LUSC cis rs796364 0.715 rs11688872 chr2:201052418 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.8 -0.39 7.75e-14 Schizophrenia; LUSC cis rs9467773 1.000 rs6456734 chr6:26566965 G/T cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs7945705 0.776 rs2316865 chr11:8815470 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.35 6.95 0.36 1.98e-11 Hemoglobin concentration; LUSC trans rs7824557 0.527 rs10109537 chr8:11239640 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.48 -0.38 6.57e-13 Retinal vascular caliber; LUSC trans rs62458065 0.713 rs921406 chr7:32486205 G/C cg00845942 chr12:64062724 DPY19L2 -0.56 -6.74 -0.35 7.03e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7560272 0.723 rs6722867 chr2:73816285 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -7.33 -0.37 1.76e-12 Schizophrenia; LUSC cis rs10838532 0.591 rs11038743 chr11:46029826 T/A cg24204282 chr11:45944920 GYLTL1B 0.43 5.8 0.3 1.53e-8 Axial length; LUSC cis rs11209002 0.614 rs4655673 chr1:67555018 T/C cg02640540 chr1:67518911 SLC35D1 0.65 9.18 0.45 4.77e-18 Crohn's disease; LUSC cis rs722599 1.000 rs722599 chr14:75327443 T/C cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.57 -0.38 3.77e-13 IgG glycosylation; LUSC trans rs4332037 0.950 rs11771828 chr7:1941003 T/C cg25206134 chr2:45395956 NA 0.57 6.52 0.34 2.6200000000000003e-10 Bipolar disorder; LUSC cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 28.75 0.84 2.4e-92 Chronic sinus infection; LUSC cis rs1691799 0.867 rs1168333 chr12:66761377 G/A cg16791601 chr12:66731901 HELB -0.69 -12.08 -0.55 4.07e-28 White blood cell count (basophil); LUSC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.4 0.53 1.17e-25 Colorectal cancer; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.97 0.4 2.6e-14 Prudent dietary pattern; LUSC cis rs669446 0.533 rs11210913 chr1:44222597 G/A cg15962314 chr1:44399869 ARTN 0.24 5.7 0.3 2.57e-8 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs3087591 1.000 rs12600974 chr17:29589360 A/G cg24425628 chr17:29625626 OMG;NF1 0.56 8.05 0.4 1.48e-14 Hip circumference; LUSC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg00129232 chr17:37814104 STARD3 -0.43 -6.32 -0.33 8.52e-10 Asthma; LUSC cis rs11711311 0.955 rs9813630 chr3:113377361 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.4 0.33 5.15e-10 IgG glycosylation; LUSC cis rs4253772 0.938 rs77378083 chr22:46639386 G/A cg09491104 chr22:46646882 C22orf40 -0.63 -6.55 -0.34 2.18e-10 LDL cholesterol;Cholesterol, total; LUSC trans rs208520 1.000 rs72884033 chr6:66995747 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 11.93 0.55 1.4e-27 Exhaled nitric oxide output; LUSC cis rs77633900 0.614 rs1905694 chr15:76951772 T/C cg21673338 chr15:77095150 SCAPER -0.78 -7.76 -0.39 1.06e-13 Non-glioblastoma glioma;Glioma; LUSC trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg20290983 chr6:43655470 MRPS18A 0.91 14.91 0.63 6.85e-39 IgG glycosylation; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.07 0.4 1.27e-14 Prudent dietary pattern; LUSC cis rs7945705 0.791 rs10769958 chr11:8815115 T/C cg12365402 chr11:9010492 NRIP3 -0.46 -8.45 -0.42 9.12e-16 Hemoglobin concentration; LUSC cis rs965469 0.901 rs6037563 chr20:3326568 G/A cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.3 3.48e-8 IFN-related cytopenia; LUSC cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg19748678 chr4:122722346 EXOSC9 0.65 9.79 0.47 4.47e-20 Type 2 diabetes; LUSC cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg07061783 chr6:25882402 NA -0.37 -5.87 -0.31 1.02e-8 Blood metabolite levels; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg04025307 chr7:1156635 C7orf50 0.53 8.38 0.42 1.47e-15 Longevity;Endometriosis; LUSC cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs72949976 0.707 rs10932473 chr2:214039057 C/T cg08319019 chr2:214017104 IKZF2 -0.54 -7.29 -0.37 2.22e-12 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.26 0.32 1.17e-9 Lung cancer; LUSC cis rs7589342 0.660 rs1897169 chr2:106397624 C/T cg09152813 chr2:106391379 NCK2 0.42 6.71 0.34 8.55e-11 Addiction; LUSC cis rs9323205 0.798 rs4465517 chr14:51673715 C/A cg23942311 chr14:51606299 NA 0.38 7.65 0.39 2.15e-13 Cancer; LUSC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.24 0.52 4.42e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg07424592 chr7:64974309 NA 0.67 5.96 0.31 6.37e-9 Diabetic kidney disease; LUSC cis rs394563 0.591 rs237028 chr6:149718650 C/T cg03678062 chr6:149772716 ZC3H12D -0.3 -6.25 -0.32 1.26e-9 Dupuytren's disease; LUSC cis rs10791323 0.569 rs11533204 chr11:133743644 A/G cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC cis rs8017423 0.607 rs10142482 chr14:90848280 G/T cg04374321 chr14:90722782 PSMC1 -0.4 -6.03 -0.31 4.25e-9 Mortality in heart failure; LUSC cis rs4789693 0.518 rs6502117 chr17:80452592 G/C cg04308225 chr17:80449738 NA 0.4 6.65 0.34 1.21e-10 Glucocorticoid-induced osteonecrosis; LUSC cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC cis rs6088580 0.524 rs6088565 chr20:33254986 A/C cg24642439 chr20:33292090 TP53INP2 -0.47 -6.85 -0.35 3.67e-11 Glomerular filtration rate (creatinine); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18187865 chr6:34857018 ANKS1A;TAF11 0.5 7.36 0.37 1.41e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10761482 0.861 rs2061491 chr10:62103675 T/C cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg17330251 chr7:94953956 PON1 0.54 10.63 0.5 6.41e-23 Paraoxonase activity; LUSC cis rs2439831 1.000 rs2264239 chr15:43765533 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs2439831 1.000 rs2251538 chr15:43767209 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.37 0.64 1.09e-40 Platelet count; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg08888203 chr3:10149979 C3orf24 0.62 8.05 0.4 1.45e-14 Alzheimer's disease; LUSC cis rs7100689 0.646 rs7092237 chr10:82165640 A/G cg01528321 chr10:82214614 TSPAN14 0.84 13.07 0.58 8.17e-32 Post bronchodilator FEV1; LUSC cis rs2629540 0.882 rs10901813 chr10:126429875 G/A cg08799069 chr10:126477246 METTL10 -0.68 -9.81 -0.47 3.92e-20 Cocaine dependence; LUSC cis rs9326248 0.813 rs4938350 chr11:117022276 A/G cg26566898 chr11:117069891 TAGLN 0.37 5.98 0.31 5.75e-9 Blood protein levels; LUSC cis rs8077577 0.945 rs11656035 chr17:18086025 T/C cg16794390 chr17:18148240 FLII 0.44 6.19 0.32 1.72e-9 Obesity-related traits; LUSC cis rs2970818 0.831 rs2909380 chr12:4607342 A/T cg11146114 chr12:4671731 NA -0.59 -5.99 -0.31 5.58e-9 Phosphorus levels; LUSC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18404041 chr3:52824283 ITIH1 -0.54 -10.44 -0.5 2.98e-22 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.655 rs2758848 chr6:86347605 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -7.22 -0.37 3.55e-12 Response to antipsychotic treatment; LUSC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg03948781 chr1:205179583 DSTYK 0.3 5.65 0.3 3.5e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9739070 1 rs9739070 chr12:123771032 A/G cg13010344 chr12:123464640 ARL6IP4 -0.54 -6.87 -0.35 3.15e-11 Allergy; LUSC cis rs9463078 0.809 rs9369515 chr6:44812515 T/G cg25276700 chr6:44698697 NA -0.3 -5.85 -0.3 1.19e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.62 10.3 0.49 8.92e-22 Lymphocyte counts; LUSC cis rs10782582 0.609 rs5745485 chr1:76349534 C/G cg03433033 chr1:76189801 ACADM -0.4 -6.01 -0.31 4.82e-9 Daytime sleep phenotypes; LUSC cis rs1506636 1.000 rs659416 chr7:123401764 A/G cg03229431 chr7:123269106 ASB15 -0.65 -10.73 -0.51 2.86e-23 Plateletcrit;Platelet count; LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.68 0.3 2.88e-8 Menopause (age at onset); LUSC cis rs6690583 1.000 rs2304641 chr1:85513398 C/T cg22153463 chr1:85462885 MCOLN2 0.68 7.46 0.38 7.72e-13 Serum sulfate level; LUSC cis rs7809950 0.954 rs12673675 chr7:107113220 T/C cg23024343 chr7:107201750 COG5 -0.54 -8.73 -0.43 1.23e-16 Coronary artery disease; LUSC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg23711669 chr6:146136114 FBXO30 0.9 17.22 0.69 5.08e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.570 rs7315655 chr12:33912869 G/A cg26384229 chr12:38710491 ALG10B 0.52 7.78 0.39 8.87e-14 Morning vs. evening chronotype; LUSC cis rs2762353 0.524 rs3923 chr6:25783315 T/C cg03264133 chr6:25882463 NA 0.35 5.91 0.31 8.64e-9 Blood metabolite levels; LUSC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg01341218 chr17:43662625 NA -0.73 -10.48 -0.5 2.06e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3916 0.911 rs2239758 chr12:121162637 A/G cg27246729 chr12:121163418 ACADS 0.5 7.27 0.37 2.65e-12 Urinary metabolites (H-NMR features); LUSC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg02079420 chr8:82753780 SNX16 -0.38 -5.79 -0.3 1.64e-8 Diastolic blood pressure; LUSC cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg21535247 chr6:8435926 SLC35B3 0.6 9.37 0.46 1.13e-18 Motion sickness; LUSC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg08859206 chr1:53392774 SCP2 0.52 9.02 0.44 1.49e-17 Monocyte count; LUSC cis rs735860 0.737 rs2397139 chr6:53150804 C/G cg10236188 chr6:53219634 NA -0.38 -5.89 -0.31 9.37e-9 Glaucoma; LUSC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg06544989 chr22:39130855 UNC84B 0.33 5.81 0.3 1.46e-8 Menopause (age at onset); LUSC cis rs6747952 0.899 rs2880132 chr2:239082976 G/A cg17459225 chr2:239074497 NA 0.33 5.68 0.3 2.88e-8 Mean corpuscular hemoglobin concentration; LUSC cis rs17253792 0.822 rs75049893 chr14:56089158 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.95 -0.48 1.38e-20 Glomerular filtration rate (creatinine); LUSC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg00310523 chr12:86230176 RASSF9 0.45 8.27 0.41 3.14e-15 Major depressive disorder; LUSC trans rs9747201 1.000 rs56283054 chr17:80135326 C/T cg07393940 chr7:158741817 NA -0.53 -8.68 -0.43 1.78e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg11752832 chr7:134001865 SLC35B4 0.6 9.38 0.46 1.04e-18 Mean platelet volume; LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg03188948 chr7:1209495 NA 0.67 7.1 0.36 7.38e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg21963583 chr11:68658836 MRPL21 0.57 8.5 0.42 6.54e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9487051 0.768 rs461487 chr6:109525504 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.73 -0.3 2.23e-8 Reticulocyte fraction of red cells; LUSC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.63 -8.64 -0.43 2.42e-16 Body mass index (adult); LUSC trans rs35110281 0.565 rs7278003 chr21:44966069 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.72 0.54 8.02e-27 Mean corpuscular volume; LUSC cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg02153584 chr22:29168773 CCDC117 0.6 9.07 0.44 1.03e-17 Lymphocyte counts; LUSC cis rs4474465 1.000 rs7950756 chr11:78157309 A/G cg27205649 chr11:78285834 NARS2 -0.51 -6.0 -0.31 5.01e-9 Alzheimer's disease (survival time); LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg00166722 chr3:10149974 C3orf24 0.61 8.47 0.42 7.9e-16 Alzheimer's disease; LUSC cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg21535247 chr6:8435926 SLC35B3 0.57 8.91 0.44 3.35e-17 Motion sickness; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.27 0.45 2.34e-18 Prudent dietary pattern; LUSC cis rs9581857 0.556 rs1885990 chr13:28040502 C/T cg22138327 chr13:27999177 GTF3A 0.7 9.58 0.46 2.23e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs12134245 0.874 rs35115044 chr1:92021650 A/G cg02896835 chr1:92012615 NA -0.53 -8.93 -0.44 2.88e-17 Breast cancer; LUSC cis rs9395066 0.545 rs12209076 chr6:44833423 G/A cg25276700 chr6:44698697 NA 0.3 6.05 0.31 3.87e-9 Height; LUSC cis rs10979 0.603 rs9321920 chr6:143883588 C/G cg25407410 chr6:143891975 LOC285740 -0.67 -8.99 -0.44 1.93e-17 Hypospadias; LUSC cis rs17270561 0.666 rs4712971 chr6:25771900 T/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.13 0.36 6.3e-12 Iron status biomarkers; LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.5 0.46 4.05e-19 Bipolar disorder; LUSC cis rs1018836 0.923 rs4735260 chr8:91617157 C/G cg16814680 chr8:91681699 NA 0.77 13.27 0.59 1.41e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg00810483 chr4:3375144 RGS12 0.31 5.95 0.31 6.64e-9 Serum sulfate level; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17322163 chr12:51632344 DAZAP2 -0.53 -6.88 -0.35 3.01e-11 Bipolar disorder and schizophrenia; LUSC trans rs4332037 1.000 rs6947019 chr7:1950337 G/A cg11693508 chr17:37793320 STARD3 0.65 7.95 0.4 2.86e-14 Bipolar disorder; LUSC cis rs5769707 0.609 rs135861 chr22:49998118 A/G cg20744362 chr22:50050164 C22orf34 0.37 6.93 0.35 2.19e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs317689 0.690 rs10878946 chr12:69642315 C/T cg11871910 chr12:69753446 YEATS4 0.44 5.69 0.3 2.81e-8 Response to diuretic therapy; LUSC cis rs10934753 0.560 rs73859048 chr3:125931603 G/A cg01346077 chr3:125931526 NA 0.53 10.13 0.48 3.35e-21 Plasma homocysteine levels (post-methionine load test); LUSC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg09238746 chr17:78121135 EIF4A3 0.56 8.39 0.42 1.4e-15 Yeast infection; LUSC cis rs13401104 0.796 rs1530956 chr2:237111086 T/C cg19324714 chr2:237145437 ASB18 0.43 5.79 0.3 1.6e-8 Educational attainment; LUSC cis rs4474465 0.850 rs4565922 chr11:78260699 A/G cg27205649 chr11:78285834 NARS2 0.52 6.2 0.32 1.7e-9 Alzheimer's disease (survival time); LUSC cis rs2933343 0.729 rs6790091 chr3:128608751 G/C cg11901034 chr3:128598214 ACAD9 -0.4 -6.21 -0.32 1.57e-9 IgG glycosylation; LUSC cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg12615879 chr12:58013172 SLC26A10 0.37 8.8 0.43 7.34e-17 Multiple sclerosis; LUSC cis rs8060686 0.545 rs12598630 chr16:68258852 T/G cg05110241 chr16:68378359 PRMT7 -0.64 -7.0 -0.36 1.41e-11 HDL cholesterol;Metabolic syndrome; LUSC trans rs5756813 1.000 rs1074407 chr22:38156183 T/A cg19894588 chr14:64061835 NA 0.6 8.73 0.43 1.24e-16 Optic cup area;Vertical cup-disc ratio; LUSC cis rs1348850 0.526 rs10930802 chr2:178460095 A/G cg22681709 chr2:178499509 PDE11A -0.39 -5.66 -0.3 3.25e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.71 -0.39 1.42e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg04511125 chr2:88470314 THNSL2 -0.43 -6.48 -0.33 3.34e-10 Response to metformin (IC50); LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg10802521 chr3:52805072 NEK4 -0.5 -7.75 -0.39 1.09e-13 Intelligence (multi-trait analysis); LUSC cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg12219531 chr12:120966889 COQ5 0.61 8.11 0.41 9.99e-15 High light scatter reticulocyte count; LUSC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs921665 0.831 rs11690724 chr2:3188333 T/G cg02624386 chr2:3182749 NA 0.59 6.59 0.34 1.68e-10 World class endurance athleticism; LUSC cis rs2762353 0.935 rs2328895 chr6:25802083 C/T cg03517284 chr6:25882590 NA -0.43 -7.74 -0.39 1.2e-13 Blood metabolite levels; LUSC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs782590 0.807 rs782572 chr2:55912120 T/C cg03859395 chr2:55845619 SMEK2 0.85 15.18 0.64 5.99e-40 Metabolic syndrome; LUSC cis rs7075426 0.669 rs3858279 chr10:88257602 A/G cg07322936 chr10:88137208 NA 0.45 6.45 0.33 3.84e-10 Migraine without aura; LUSC cis rs6982240 0.514 rs1865247 chr8:142274654 A/T cg00131261 chr8:142287264 NA -0.36 -6.11 -0.32 2.84e-9 Tonsillectomy; LUSC cis rs11098499 0.866 rs6857892 chr4:120282696 G/T cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs41271473 0.950 rs72750042 chr1:228854138 T/C cg10167378 chr1:228756711 NA 0.6 7.26 0.37 2.8e-12 Chronic lymphocytic leukemia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08436942 chr4:4249992 TMEM128 0.4 6.06 0.31 3.66e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.19 -0.37 4.35e-12 Bipolar disorder; LUSC cis rs2463822 0.925 rs2513075 chr11:62102408 C/T cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs548181 0.668 rs579661 chr11:125474766 A/G cg03464685 chr11:125439445 EI24 1.26 15.45 0.65 5.01e-41 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12530845 0.945 rs73725433 chr7:135313251 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.93 -0.48 1.61e-20 Red blood cell traits; LUSC cis rs4654899 0.865 rs72975078 chr1:21476196 A/G cg01072550 chr1:21505969 NA -0.51 -7.55 -0.38 4.19e-13 Superior frontal gyrus grey matter volume; LUSC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg11608241 chr8:8085544 FLJ10661 0.43 6.11 0.32 2.81e-9 Systolic blood pressure; LUSC cis rs3008870 0.755 rs2815368 chr1:67500778 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.54 0.57 8.04e-30 Lymphocyte percentage of white cells; LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg16606324 chr3:10149918 C3orf24 0.68 9.9 0.48 2.05e-20 Alzheimer's disease; LUSC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg06634786 chr22:41940651 POLR3H -0.55 -6.39 -0.33 5.42e-10 Vitiligo; LUSC cis rs367943 0.635 rs2222144 chr5:112712208 G/T cg12552261 chr5:112820674 MCC 0.35 5.71 0.3 2.46e-8 Type 2 diabetes; LUSC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -6.19 -0.32 1.78e-9 Self-reported allergy; LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.81 -0.35 4.6e-11 Menopause (age at onset); LUSC cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg05340658 chr4:99064831 C4orf37 0.65 10.81 0.51 1.44e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg11766577 chr21:47581405 C21orf56 0.5 7.62 0.38 2.61e-13 Testicular germ cell tumor; LUSC cis rs12579753 1.000 rs34031374 chr12:82235615 G/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs3741151 1.000 rs75109191 chr11:73023532 T/C cg17517138 chr11:73019481 ARHGEF17 1.14 9.61 0.47 1.78e-19 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs11229555 0.645 rs12802819 chr11:58174747 T/G cg15696309 chr11:58395628 NA -0.64 -7.96 -0.4 2.69e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs73200209 0.744 rs3214009 chr12:116486852 C/T cg01776926 chr12:116560359 MED13L 0.49 5.68 0.3 2.97e-8 Total body bone mineral density; LUSC trans rs12579753 0.917 rs10862360 chr12:82187411 A/G cg07923666 chr12:49932857 KCNH3 -0.49 -6.12 -0.32 2.58e-9 Resting heart rate; LUSC cis rs62577244 0.645 rs12001733 chr9:138431675 G/T cg14097499 chr9:138441348 OBP2A 0.3 6.19 0.32 1.77e-9 Subcutaneous adipose tissue (sex interaction);Subcutaneous adipose tissue; LUSC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs6121246 0.559 rs6058468 chr20:30406448 C/A cg18721089 chr20:30220636 NA -0.31 -5.69 -0.3 2.77e-8 Mean corpuscular hemoglobin; LUSC cis rs2692947 0.826 rs7423942 chr2:96645257 G/A cg22654517 chr2:96458247 NA 0.33 6.83 0.35 4.07e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg20790798 chr5:1857306 NA -0.46 -7.84 -0.39 6.2e-14 Cardiovascular disease risk factors; LUSC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.21e-12 Schizophrenia; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg06603828 chr5:149829668 RPS14 0.43 6.06 0.31 3.64e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg26314531 chr2:26401878 FAM59B -0.66 -9.12 -0.45 7.39e-18 Gut microbiome composition (summer); LUSC trans rs6600671 0.934 rs11249429 chr1:121291080 C/T cg00646200 chr1:148855367 NA -0.49 -7.75 -0.39 1.12e-13 Hip geometry; LUSC cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg18132916 chr6:79620363 NA -0.4 -6.08 -0.32 3.29e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg03676636 chr4:99064102 C4orf37 0.32 7.05 0.36 1.06e-11 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 0.534 rs11052979 chr12:34035774 G/T cg13010199 chr12:38710504 ALG10B 0.55 8.36 0.42 1.74e-15 Morning vs. evening chronotype; LUSC cis rs4919694 1.000 rs4917382 chr10:104838510 G/A cg04362960 chr10:104952993 NT5C2 1.18 14.03 0.61 1.78e-35 Arsenic metabolism; LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg03354898 chr7:1950403 MAD1L1 -0.37 -7.21 -0.37 3.84e-12 Bipolar disorder and schizophrenia; LUSC cis rs9311676 1.000 rs9311676 chr3:58470351 A/G cg26110898 chr3:58419937 PDHB -0.39 -6.16 -0.32 2.08e-9 Systemic lupus erythematosus; LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg27170947 chr2:26402098 FAM59B 0.72 11.0 0.52 3.29e-24 Gut microbiome composition (summer); LUSC cis rs11247915 0.600 rs3795686 chr1:26582091 G/A cg15628303 chr1:26608928 UBXN11 0.48 7.98 0.4 2.4e-14 Obesity-related traits; LUSC cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs3857536 0.740 rs9354392 chr6:66894555 G/T cg07460842 chr6:66804631 NA -0.47 -6.62 -0.34 1.41e-10 Blood trace element (Cu levels); LUSC cis rs6964587 1.000 rs7797369 chr7:91570615 C/A cg01689657 chr7:91764605 CYP51A1 -0.33 -6.06 -0.31 3.68e-9 Breast cancer; LUSC cis rs950027 0.620 rs1617634 chr15:45615578 A/G cg09092052 chr15:45571596 NA -0.43 -6.03 -0.31 4.27e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs6484504 0.512 rs2774402 chr11:31312897 G/C cg06552810 chr11:31128660 NA 0.41 7.3 0.37 2.08e-12 Red blood cell count; LUSC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg09580153 chr6:41068724 NFYA;LOC221442 0.46 6.9 0.35 2.65e-11 Alzheimer's disease (late onset); LUSC cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg16339924 chr4:17578868 LAP3 0.47 7.33 0.37 1.74e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs853679 0.517 rs4713137 chr6:28083521 C/G cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg26039829 chr8:22132926 PIWIL2 0.42 7.58 0.38 3.4e-13 Hypertriglyceridemia; LUSC cis rs11971779 0.618 rs9640925 chr7:139085288 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs8141529 0.778 rs5762795 chr22:29182500 C/A cg15103426 chr22:29168792 CCDC117 0.58 7.85 0.39 5.64e-14 Lymphocyte counts; LUSC cis rs3736594 1.000 rs13013484 chr2:27988821 G/A cg27432699 chr2:27873401 GPN1 -0.61 -8.77 -0.43 9.2e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs13031619 0.607 rs13001751 chr2:3695870 A/G cg19052272 chr2:3704530 ALLC -0.33 -6.37 -0.33 6.31e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs4953076 0.533 rs1551315 chr2:44407618 G/A cg04920474 chr2:44395004 PPM1B 0.66 8.58 0.43 3.55e-16 Height; LUSC cis rs734999 0.545 rs28532547 chr1:2561286 T/G cg18932078 chr1:2524107 MMEL1 -0.31 -6.84 -0.35 3.79e-11 Ulcerative colitis; LUSC cis rs3892630 0.588 rs7248798 chr19:33303684 G/T cg22980127 chr19:33182716 NUDT19 0.9 13.02 0.58 1.21e-31 Red blood cell traits; LUSC trans rs890100 0.673 rs11687295 chr2:56658548 T/C cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.75e-9 Gut microbiome composition (summer); LUSC cis rs7647973 0.925 rs6446256 chr3:49224210 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.46 6.85 0.35 3.58e-11 Menarche (age at onset); LUSC cis rs981844 0.740 rs6841173 chr4:154682563 A/G cg14289246 chr4:154710475 SFRP2 -0.48 -6.93 -0.35 2.17e-11 Response to statins (LDL cholesterol change); LUSC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg13722127 chr7:150037890 RARRES2 0.38 5.8 0.3 1.58e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs7264396 0.635 rs6060720 chr20:34548336 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs1595825 0.891 rs6751690 chr2:198574523 G/A cg00982548 chr2:198649783 BOLL -0.53 -6.71 -0.34 8.13e-11 Ulcerative colitis; LUSC cis rs11785400 1.000 rs6997670 chr8:143737915 G/A cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg04267008 chr7:1944627 MAD1L1 0.57 8.76 0.43 1.03e-16 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.955 rs35434465 chr4:120169378 C/G cg25214090 chr10:38739885 LOC399744 0.49 7.17 0.37 4.76e-12 Corneal astigmatism; LUSC cis rs9326248 0.520 rs10892060 chr11:116881662 C/A cg26566898 chr11:117069891 TAGLN 0.33 6.25 0.32 1.29e-9 Blood protein levels; LUSC trans rs1486139 0.967 rs10252585 chr7:46281477 A/G cg17534202 chr9:96721102 NA -0.34 -5.96 -0.31 6.36e-9 Select biomarker traits; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg20887711 chr4:1340912 KIAA1530 -0.43 -6.47 -0.33 3.47e-10 Obesity-related traits; LUSC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -8.35 -0.42 1.78e-15 Alzheimer's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24973791 chr3:136471376 STAG1 -0.46 -6.74 -0.35 6.87e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12940923 0.529 rs2240261 chr17:56381389 C/T cg19466818 chr17:56409534 MIR142 0.3 5.88 0.31 1.02e-8 Circulating myeloperoxidase levels (plasma); LUSC cis rs317689 0.819 rs317683 chr12:69713630 T/G cg20891283 chr12:69753455 YEATS4 0.45 6.13 0.32 2.48e-9 Response to diuretic therapy; LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18404041 chr3:52824283 ITIH1 -0.58 -11.15 -0.52 9.39e-25 Bipolar disorder; LUSC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -7.43 -0.38 9.03e-13 Retinal vascular caliber; LUSC trans rs6600671 0.934 rs11249348 chr1:121188302 T/C cg00646200 chr1:148855367 NA 0.48 7.78 0.39 9.35e-14 Hip geometry; LUSC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08109568 chr15:31115862 NA -0.59 -8.24 -0.41 3.89e-15 Huntington's disease progression; LUSC cis rs2742417 1.000 rs2742421 chr3:45732515 G/T cg04837898 chr3:45731254 SACM1L 0.38 6.17 0.32 1.93e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg03676636 chr4:99064102 C4orf37 0.34 7.56 0.38 3.98e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg05165339 chr4:1420672 NA 0.28 6.24 0.32 1.34e-9 Longevity; LUSC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg05896524 chr21:47604654 C21orf56 0.51 7.64 0.39 2.38e-13 Testicular germ cell tumor; LUSC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg06008330 chr7:65541103 ASL -0.41 -6.4 -0.33 5.13e-10 Aortic root size; LUSC cis rs2354432 0.607 rs12404113 chr1:146750343 C/A cg25205988 chr1:146714368 CHD1L -0.99 -9.33 -0.45 1.49e-18 Mitochondrial DNA levels; LUSC cis rs2282300 0.739 rs12577729 chr11:30257377 C/T cg25418670 chr11:30344373 C11orf46 -0.65 -9.32 -0.45 1.69e-18 Morning vs. evening chronotype; LUSC cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs950169 0.922 rs12915832 chr15:85111457 C/T cg11189052 chr15:85197271 WDR73 0.47 5.93 0.31 7.49e-9 Schizophrenia; LUSC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg03576123 chr11:487126 PTDSS2 -0.45 -5.81 -0.3 1.45e-8 Systemic lupus erythematosus; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg11494091 chr17:61959527 GH2 0.64 13.28 0.59 1.29e-32 Prudent dietary pattern; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg10802521 chr3:52805072 NEK4 -0.49 -7.74 -0.39 1.2e-13 Electroencephalogram traits; LUSC cis rs6728642 0.803 rs11891457 chr2:97632449 G/T cg26665480 chr2:98280029 ACTR1B -0.65 -5.77 -0.3 1.76e-8 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs12681287 0.752 rs7822268 chr8:87306440 G/T cg27223183 chr8:87520930 FAM82B -0.47 -5.9 -0.31 8.75e-9 Caudate activity during reward; LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7615952 0.515 rs4267608 chr3:125680500 C/T cg05084668 chr3:125655381 ALG1L -0.65 -9.92 -0.48 1.64e-20 Blood pressure (smoking interaction); LUSC trans rs12614435 0.512 rs12693162 chr2:179488194 C/T cg14011486 chr1:26737247 LIN28 0.44 5.95 0.31 6.61e-9 Atrial fibrillation; LUSC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg18190219 chr22:46762943 CELSR1 -0.55 -6.38 -0.33 5.88e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs3858526 0.834 rs7129481 chr11:5991114 G/T cg13902645 chr11:5959945 NA -0.59 -8.04 -0.4 1.59e-14 DNA methylation (variation); LUSC cis rs11098499 0.821 rs10032151 chr4:120391628 C/T cg09307838 chr4:120376055 NA 0.78 11.14 0.52 1.05e-24 Corneal astigmatism; LUSC cis rs2540226 0.684 rs35761077 chr2:40006442 C/T cg23576258 chr2:39999331 THUMPD2 0.34 5.82 0.3 1.4e-8 Personality dimensions; LUSC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg13206674 chr6:150067644 NUP43 0.59 9.21 0.45 3.8e-18 Lung cancer; LUSC cis rs7824557 0.767 rs4559208 chr8:11153925 C/G cg27411982 chr8:10470053 RP1L1 0.37 5.99 0.31 5.36e-9 Retinal vascular caliber; LUSC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg00745463 chr17:30367425 LRRC37B -0.83 -9.75 -0.47 6.44e-20 Hip circumference adjusted for BMI; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg14004847 chr7:1930337 MAD1L1 -0.51 -7.53 -0.38 4.89e-13 Bipolar disorder and schizophrenia; LUSC cis rs870825 0.929 rs56106324 chr4:185589901 C/A cg04058563 chr4:185651563 MLF1IP 0.81 10.69 0.5 3.94e-23 Blood protein levels; LUSC cis rs6005807 0.719 rs12169880 chr22:29054875 G/C cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs1801251 0.893 rs11687128 chr2:233608901 T/C cg08000102 chr2:233561755 GIGYF2 0.68 11.26 0.52 3.82e-25 Coronary artery disease; LUSC cis rs6964587 0.839 rs13229273 chr7:91444472 G/A cg22709100 chr7:91322751 NA 0.47 6.87 0.35 3.1e-11 Breast cancer; LUSC cis rs4478858 0.647 rs12752761 chr1:31710888 T/C cg00250761 chr1:31883323 NA -0.35 -8.36 -0.42 1.76e-15 Alcohol dependence; LUSC cis rs208520 0.837 rs208509 chr6:66941706 A/G cg07460842 chr6:66804631 NA -1.0 -14.11 -0.61 8.91e-36 Exhaled nitric oxide output; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg26745402 chr7:95402189 DYNC1I1 0.33 6.21 0.32 1.59e-9 Schizophrenia; LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg11494091 chr17:61959527 GH2 0.63 13.44 0.59 3.14e-33 Prudent dietary pattern; LUSC cis rs6696846 0.715 rs61822659 chr1:205142847 G/A cg21545522 chr1:205238299 TMCC2 0.46 8.4 0.42 1.33e-15 Red blood cell count; LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.96e-29 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC cis rs10740039 0.883 rs1442540 chr10:62413306 C/T cg18175470 chr10:62150864 ANK3 0.44 6.66 0.34 1.16e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg07936489 chr17:37558343 FBXL20 0.72 10.11 0.48 3.74e-21 Glomerular filtration rate (creatinine); LUSC cis rs7119 0.604 rs1055691 chr15:77864625 G/C cg27398640 chr15:77910606 LINGO1 0.35 7.85 0.39 5.86e-14 Type 2 diabetes; LUSC cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg23711669 chr6:146136114 FBXO30 0.88 16.36 0.67 1.31e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs11648785 0.810 rs4354938 chr16:90098828 G/C cg16611967 chr16:90144006 NA 0.48 6.22 0.32 1.45e-9 Tanning; LUSC cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 -0.47 -7.53 -0.38 4.63e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9303401 0.659 rs17822908 chr17:56801778 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs6121246 0.909 rs6060812 chr20:30292803 C/T cg13852791 chr20:30311386 BCL2L1 0.88 11.94 0.55 1.3e-27 Mean corpuscular hemoglobin; LUSC cis rs3806843 0.966 rs11958868 chr5:140201420 T/C cg26395211 chr5:140044315 WDR55 -0.37 -5.7 -0.3 2.69e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs343496 0.756 rs376690 chr9:6134926 C/T cg15581944 chr11:35551852 NA -0.33 -6.02 -0.31 4.52e-9 Asthma and hay fever; LUSC cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.45 6.87 0.35 3.16e-11 Colorectal cancer; LUSC cis rs7843479 1.000 rs727694 chr8:21849962 T/C cg17168535 chr8:21777572 XPO7 0.65 9.66 0.47 1.23e-19 Mean corpuscular volume; LUSC cis rs17270561 0.779 rs12210620 chr6:25884785 T/C cg17691542 chr6:26056736 HIST1H1C 0.83 11.18 0.52 7.24e-25 Iron status biomarkers; LUSC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.65 0.3 3.46e-8 Intelligence (multi-trait analysis); LUSC cis rs5758659 1.000 rs5758659 chr22:42622003 C/T cg15557168 chr22:42548783 NA -0.45 -7.58 -0.38 3.38e-13 Cognitive function; LUSC trans rs67340775 0.541 rs200968 chr6:27859568 T/C cg05267876 chr1:229644265 NUP133 -0.56 -6.08 -0.32 3.25e-9 Lung cancer in ever smokers; LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg08677398 chr8:58056175 NA 0.58 7.13 0.36 6.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.537 rs10772993 chr12:123644714 A/G cg13010344 chr12:123464640 ARL6IP4 -0.47 -5.91 -0.31 8.29e-9 Neutrophil percentage of white cells; LUSC cis rs6754311 0.597 rs2278544 chr2:136546110 A/G cg07169764 chr2:136633963 MCM6 -0.73 -9.84 -0.47 3.16e-20 Mosquito bite size; LUSC cis rs13315871 0.929 rs35004361 chr3:58313394 T/C cg20936604 chr3:58311152 NA -0.73 -7.09 -0.36 7.97e-12 Cholesterol, total; LUSC cis rs11190604 1.000 rs2489048 chr10:102348497 G/T cg07080220 chr10:102295463 HIF1AN 0.67 8.77 0.43 8.99e-17 Palmitoleic acid (16:1n-7) levels; LUSC trans rs6502050 0.842 rs6502053 chr17:80066714 C/T cg07393940 chr7:158741817 NA -0.36 -6.46 -0.33 3.76e-10 Life satisfaction; LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.61 0.38 2.74e-13 Bipolar disorder; LUSC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg13319975 chr6:146136371 FBXO30 0.5 7.59 0.38 3.24e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2692947 0.760 rs2438924 chr2:96645069 A/G cg22654517 chr2:96458247 NA 0.33 6.83 0.35 4.07e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs12155623 0.603 rs2203065 chr8:49881987 A/G cg22283653 chr8:49824208 NA -0.3 -6.16 -0.32 2.06e-9 Sudden cardiac arrest; LUSC cis rs243505 1.000 rs243521 chr7:148421571 T/C cg09806900 chr7:148480153 CUL1 -0.48 -6.88 -0.35 3.02e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17253792 0.822 rs17253716 chr14:56153661 G/C cg01858014 chr14:56050164 KTN1 -0.82 -6.77 -0.35 5.9e-11 Putamen volume; LUSC cis rs6964587 1.000 rs60147309 chr7:91736098 C/G cg17063962 chr7:91808500 NA 0.59 9.29 0.45 2.06e-18 Breast cancer; LUSC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg27068330 chr11:65405492 SIPA1 -0.46 -5.96 -0.31 6.51e-9 Breast cancer; LUSC cis rs6580649 0.941 rs7310579 chr12:48427523 G/A cg24011408 chr12:48396354 COL2A1 -0.52 -6.9 -0.35 2.59e-11 Lung cancer; LUSC cis rs2286503 0.839 rs4722188 chr7:22860211 C/G cg11367502 chr7:22862612 TOMM7 0.44 6.01 0.31 4.83e-9 Fibrinogen; LUSC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg20573242 chr4:122745356 CCNA2 0.64 9.22 0.45 3.55e-18 Type 2 diabetes; LUSC cis rs12545109 0.800 rs1467123 chr8:57418870 C/T cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg06212747 chr3:49208901 KLHDC8B 0.42 5.73 0.3 2.2e-8 Parkinson's disease; LUSC cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg24110177 chr3:50126178 RBM5 0.53 8.57 0.42 3.91e-16 Menarche (age at onset); LUSC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg08847533 chr14:75593920 NEK9 0.85 16.21 0.66 5.49e-44 Height; LUSC cis rs2359239 0.519 rs8007145 chr14:75185748 T/A cg06637938 chr14:75390232 RPS6KL1 0.42 6.22 0.32 1.47e-9 Neuroticism (multi-trait analysis); LUSC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.64 0.47 1.43e-19 Hip circumference adjusted for BMI; LUSC cis rs9467711 0.606 rs16891725 chr6:26479150 C/T cg09904177 chr6:26538194 HMGN4 -0.63 -5.8 -0.3 1.53e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs748404 0.723 rs573169 chr15:43550581 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 8.08 0.4 1.22e-14 Lung cancer; LUSC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg11663144 chr21:46675770 NA -0.4 -6.9 -0.35 2.55e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs17818399 0.712 rs13008088 chr2:46781580 C/G cg02822958 chr2:46747628 ATP6V1E2 0.42 6.65 0.34 1.18e-10 Height; LUSC cis rs78572108 0.858 rs13409333 chr2:42265073 A/G cg00607755 chr2:42274082 PKDCC 0.37 6.56 0.34 2.03e-10 Total body bone mineral density; LUSC cis rs12701220 0.842 rs10236293 chr7:1032637 G/A cg06145435 chr7:1022769 CYP2W1 0.35 5.75 0.3 1.99e-8 Bronchopulmonary dysplasia; LUSC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.61 10.07 0.48 5.1e-21 Age at first birth; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19345165 chr11:47600677 NDUFS3;KBTBD4 -0.42 -6.11 -0.32 2.81e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2404602 0.735 rs11857327 chr15:76764263 G/C cg23625390 chr15:77176239 SCAPER -0.62 -9.51 -0.46 3.79e-19 Blood metabolite levels; LUSC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg24881330 chr22:46731750 TRMU 0.83 7.49 0.38 6.37e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs367615 0.506 rs2963021 chr5:108800365 C/T cg17395555 chr5:108820864 NA 0.5 9.29 0.45 2.1e-18 Colorectal cancer (SNP x SNP interaction); LUSC cis rs721399 0.539 rs12676857 chr8:18266572 T/C cg18736775 chr8:18248649 NAT2 -0.6 -7.09 -0.36 7.9e-12 Blood metabolite levels; LUSC cis rs1595825 0.891 rs1992313 chr2:198896766 T/C cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs67311347 0.544 rs2887965 chr3:40334154 A/G cg13683864 chr3:40499215 RPL14 0.73 12.36 0.56 3.58e-29 Renal cell carcinoma; LUSC cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg26924012 chr15:45694286 SPATA5L1 1.04 16.23 0.66 4.25e-44 Homoarginine levels; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03934478 chr11:495069 RNH1 0.9 10.5 0.5 1.76e-22 Body mass index; LUSC cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.77 0.51 1.97e-23 Bladder cancer; LUSC cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg00750074 chr16:89608354 SPG7 0.44 7.66 0.39 1.99e-13 Multiple myeloma (IgH translocation); LUSC trans rs10885582 0.846 rs4752016 chr10:116348539 C/T cg01002288 chr1:43166549 YBX1 -0.36 -6.09 -0.32 3.15e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs73416724 1.000 rs111882537 chr6:43366075 C/A cg26312998 chr6:43337775 ZNF318 0.53 6.24 0.32 1.35e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2294693 0.945 rs9349175 chr6:40982401 T/C cg14769373 chr6:40998127 UNC5CL -0.55 -7.59 -0.38 3.28e-13 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs10751667 0.666 rs6597960 chr11:977036 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.3e-10 Alzheimer's disease (late onset); LUSC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg24531977 chr5:56204891 C5orf35 -1.0 -14.65 -0.63 7.31e-38 Initial pursuit acceleration; LUSC cis rs7712401 0.601 rs35334805 chr5:122335261 G/A cg19077854 chr5:122220652 SNX24 -0.43 -9.27 -0.45 2.29e-18 Mean platelet volume; LUSC cis rs9616064 0.889 rs5767287 chr22:46996179 G/A cg25730555 chr22:47059586 GRAMD4 0.43 6.53 0.34 2.47e-10 Urate levels in obese individuals; LUSC cis rs4356932 1.000 rs6532111 chr4:76955914 T/C cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs7091068 0.616 rs7084701 chr10:95482249 A/G cg20715218 chr10:95462985 C10orf4 0.63 7.03 0.36 1.14e-11 Urinary tract infection frequency; LUSC cis rs12464559 0.522 rs7583060 chr2:152620943 C/A cg01189475 chr2:152685088 ARL5A 0.64 6.99 0.36 1.49e-11 Response to cognitive-behavioural therapy in anxiety disorder; LUSC trans rs4332037 0.539 rs57148375 chr7:2025001 G/C cg10840412 chr1:235813424 GNG4 0.6 7.74 0.39 1.21e-13 Bipolar disorder; LUSC cis rs965513 1.000 rs7020976 chr9:100547972 T/C cg13688889 chr9:100608707 NA -0.54 -8.05 -0.4 1.45e-14 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs2439831 0.850 rs28707214 chr15:44131623 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.98 0.44 2e-17 Lung cancer in ever smokers; LUSC cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg08085267 chr17:45401833 C17orf57 0.46 6.71 0.34 8.42e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs367615 0.552 rs3828603 chr5:108712068 G/C cg17395555 chr5:108820864 NA -0.47 -8.25 -0.41 3.76e-15 Colorectal cancer (SNP x SNP interaction); LUSC cis rs4363385 0.693 rs1933384 chr1:152959488 A/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.44 -0.38 8.86e-13 Inflammatory skin disease; LUSC cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg12310025 chr6:25882481 NA 0.4 6.84 0.35 3.75e-11 Blood metabolite levels; LUSC cis rs6582630 0.594 rs7308707 chr12:38450428 G/C cg26384229 chr12:38710491 ALG10B -0.56 -8.33 -0.41 2.11e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs4792901 0.765 rs9892162 chr17:41600800 T/C cg22562494 chr17:41607896 ETV4 -0.33 -6.05 -0.31 3.8e-9 Dupuytren's disease; LUSC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg23158103 chr7:148848205 ZNF398 -0.42 -6.38 -0.33 5.75e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg19468946 chr17:37922297 IKZF3 -0.38 -6.07 -0.32 3.47e-9 Self-reported allergy; LUSC cis rs7618501 1.000 rs1049256 chr3:49763338 T/C cg12257692 chr3:49977190 RBM6 -0.21 -5.68 -0.3 2.99e-8 Intelligence (multi-trait analysis); LUSC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg13451222 chr11:65405525 SIPA1 0.46 5.75 0.3 2.02e-8 Blood pressure (age interaction); LUSC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg13119609 chr19:45449297 APOC2 0.47 9.46 0.46 5.65e-19 Blood protein levels; LUSC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg18252515 chr7:66147081 NA 1.24 14.24 0.61 2.72e-36 Diabetic kidney disease; LUSC cis rs11098499 0.820 rs6829903 chr4:120506884 C/T cg09307838 chr4:120376055 NA 0.73 10.5 0.5 1.72e-22 Corneal astigmatism; LUSC cis rs7296418 0.961 rs4148863 chr12:123569375 A/G cg00376283 chr12:123451042 ABCB9 0.8 12.54 0.57 8.08e-30 Platelet count; LUSC cis rs7177699 0.557 rs4389113 chr15:79121739 G/A cg00540400 chr15:79124168 NA -0.48 -8.23 -0.41 4.2e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs568617 1.000 rs568617 chr11:65653242 C/T cg19792802 chr11:65647270 CTSW 0.41 6.23 0.32 1.38e-9 Crohn's disease; LUSC cis rs56283067 0.886 rs2023311 chr6:44678306 A/T cg20913747 chr6:44695427 NA -0.45 -7.54 -0.38 4.5e-13 Total body bone mineral density; LUSC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg12963246 chr6:28129442 ZNF389 0.48 6.63 0.34 1.34e-10 Depression; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg16606324 chr3:10149918 C3orf24 0.68 9.9 0.48 2.05e-20 Alzheimer's disease; LUSC cis rs7246967 0.673 rs6511374 chr19:22866370 T/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC trans rs11148252 0.840 rs3886077 chr13:52949053 C/A cg18335740 chr13:41363409 SLC25A15 0.54 8.86 0.44 5e-17 Lewy body disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04226401 chr1:100818170 CDC14A 0.45 6.71 0.34 8.22e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg04727924 chr7:799746 HEATR2 -0.58 -6.23 -0.32 1.42e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg22875332 chr1:76189707 ACADM 0.77 10.99 0.52 3.55e-24 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs62238980 0.614 rs117002438 chr22:32371395 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.54 0.46 3e-19 Major depressive disorder; LUSC cis rs8141529 0.764 rs5762824 chr22:29222930 C/T cg02153584 chr22:29168773 CCDC117 0.66 10.6 0.5 8.09e-23 Lymphocyte counts; LUSC cis rs909674 0.690 rs5750825 chr22:39831278 A/G cg02038168 chr22:39784481 NA -0.45 -6.83 -0.35 4.02e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg06060754 chr5:176797920 RGS14 -0.54 -8.72 -0.43 1.33e-16 Urinary electrolytes (magnesium/calcium ratio); LUSC cis rs7804356 0.954 rs3801808 chr7:26896555 T/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.23 -0.32 1.41e-9 Type 1 diabetes; LUSC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.48e-24 Aortic root size; LUSC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg12463550 chr7:65579703 CRCP -0.52 -7.53 -0.38 4.89e-13 Aortic root size; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14956593 chr14:24685421 MDP1 -0.45 -6.02 -0.31 4.54e-9 Hepatitis; LUSC cis rs4363385 0.791 rs3120744 chr1:153010330 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.2 -0.37 4.14e-12 Inflammatory skin disease; LUSC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg11812906 chr14:75593930 NEK9 0.65 10.77 0.51 2.06e-23 Height; LUSC cis rs9811920 0.809 rs6802817 chr3:99779264 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.53 -0.34 2.46e-10 Axial length; LUSC cis rs6496044 0.568 rs6496040 chr15:86064129 C/G cg13263323 chr15:86062960 AKAP13 -0.38 -6.24 -0.32 1.36e-9 Interstitial lung disease; LUSC cis rs897984 0.609 rs72800847 chr16:31022639 G/A cg02466173 chr16:30829666 NA -0.55 -10.14 -0.49 2.99e-21 Dementia with Lewy bodies; LUSC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg03526776 chr6:41159608 TREML2 -0.51 -10.63 -0.5 6.47e-23 Alzheimer's disease (late onset); LUSC cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg09184832 chr6:79620586 NA -0.36 -5.72 -0.3 2.35e-8 Intelligence (multi-trait analysis); LUSC cis rs2200578 1.000 rs12053519 chr2:99875018 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.48 0.33 3.26e-10 IgG glycosylation; LUSC cis rs12893668 0.703 rs4906336 chr14:104033265 C/G cg04998671 chr14:104000505 TRMT61A -0.47 -6.64 -0.34 1.25e-10 Reticulocyte count; LUSC cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg16989719 chr2:238392110 NA -0.42 -7.1 -0.36 7.39e-12 Prostate cancer; LUSC cis rs12477438 0.765 rs10181422 chr2:99558970 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -7.93 -0.4 3.38e-14 Chronic sinus infection; LUSC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg04756594 chr16:24857601 SLC5A11 0.47 7.02 0.36 1.21e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs868036 0.672 rs7175517 chr15:68077630 A/G cg08079166 chr15:68083412 MAP2K5 0.41 7.5 0.38 5.85e-13 Restless legs syndrome; LUSC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg13902645 chr11:5959945 NA -0.53 -7.45 -0.38 8.17e-13 DNA methylation (variation); LUSC cis rs7727544 0.582 rs3805681 chr5:131537860 T/G cg24060327 chr5:131705240 SLC22A5 -0.35 -5.69 -0.3 2.8e-8 Blood metabolite levels; LUSC cis rs16854884 0.632 rs10513234 chr3:143670957 A/G cg06585982 chr3:143692056 C3orf58 -0.49 -7.55 -0.38 4.09e-13 Economic and political preferences (feminism/equality); LUSC cis rs9790314 1.000 rs3849524 chr3:161015589 C/T cg03342759 chr3:160939853 NMD3 -0.48 -8.03 -0.4 1.68e-14 Morning vs. evening chronotype; LUSC cis rs8114671 0.562 rs6088635 chr20:33466501 A/G cg24642439 chr20:33292090 TP53INP2 0.45 6.5 0.33 2.99e-10 Height; LUSC cis rs314370 0.951 rs6706 chr7:100471044 C/T cg08558340 chr7:100472263 SRRT 0.5 6.23 0.32 1.37e-9 Resting heart rate; LUSC cis rs61931739 0.817 rs10772144 chr12:34242463 A/C cg06521331 chr12:34319734 NA -0.39 -6.71 -0.34 8.55e-11 Morning vs. evening chronotype; LUSC cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs477692 0.967 rs496692 chr10:131429100 C/T cg11019008 chr10:131425282 MGMT 0.4 6.0 0.31 5.17e-9 Response to temozolomide; LUSC cis rs6752107 0.967 rs6431661 chr2:234167421 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.73 12.11 0.55 3.07e-28 Crohn's disease;Inflammatory bowel disease; LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg16325326 chr1:53192061 ZYG11B -0.9 -16.76 -0.68 3.56e-46 Monocyte count; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.37 5.92 0.31 7.78e-9 Electroencephalogram traits; LUSC cis rs2760061 0.819 rs3094914 chr1:228206934 C/T cg18477163 chr1:228402036 OBSCN 0.63 12.0 0.55 8e-28 Diastolic blood pressure; LUSC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg12257692 chr3:49977190 RBM6 -0.25 -6.77 -0.35 5.69e-11 Intelligence (multi-trait analysis); LUSC cis rs11971779 0.680 rs6965212 chr7:139026465 G/T cg23387468 chr7:139079360 LUC7L2 0.42 6.13 0.32 2.53e-9 Diisocyanate-induced asthma; LUSC cis rs8114671 0.562 rs8117491 chr20:33510120 T/C cg07148914 chr20:33460835 GGT7 0.56 8.53 0.42 5.25e-16 Height; LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg22535103 chr8:58192502 C8orf71 -0.78 -7.98 -0.4 2.41e-14 Developmental language disorder (linguistic errors); LUSC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg21433313 chr16:3507492 NAT15 0.41 5.75 0.3 2.02e-8 Body mass index (adult); LUSC cis rs3008870 0.917 rs12044492 chr1:67461667 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs6977660 0.714 rs728156 chr7:19826309 G/C cg05791153 chr7:19748676 TWISTNB 0.67 6.93 0.35 2.24e-11 Thyroid stimulating hormone; LUSC cis rs66887589 0.616 rs11098498 chr4:120187119 T/C cg09307838 chr4:120376055 NA 0.5 7.53 0.38 4.84e-13 Diastolic blood pressure; LUSC cis rs12908161 1.000 rs17600551 chr15:85319258 A/G cg17173187 chr15:85201210 NMB 0.5 9.39 0.46 9.74e-19 Schizophrenia; LUSC cis rs174775 0.513 rs3788411 chr22:29728783 T/C cg07256473 chr22:29710276 RASL10A -0.44 -8.1 -0.41 1.02e-14 Immature fraction of reticulocytes; LUSC trans rs2864527 0.522 rs8098544 chr18:9219317 C/T cg19809734 chr13:112772980 NA -0.58 -6.0 -0.31 5.04e-9 Dental caries; LUSC cis rs9534288 0.830 rs1126365 chr13:46633196 T/A cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC trans rs2679649 1.000 rs2816121 chr6:122362907 C/T cg00167820 chr8:131663355 NA 0.53 6.2 0.32 1.68e-9 Subcutaneous adipose tissue; LUSC cis rs28374715 0.681 rs7162231 chr15:41591859 G/A cg18705301 chr15:41695430 NDUFAF1 -1.02 -21.37 -0.76 1.74e-64 Ulcerative colitis; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg07677032 chr17:61819896 STRADA 0.53 8.93 0.44 2.87e-17 Prudent dietary pattern; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01778114 chr2:216877947 MREG -0.44 -6.44 -0.33 4.24e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg08999081 chr20:33150536 PIGU 0.51 9.82 0.47 3.67e-20 Coronary artery disease; LUSC trans rs72674100 1.000 rs72874648 chr4:97964979 A/G cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg21573476 chr21:45109991 RRP1B -0.36 -5.74 -0.3 2.14e-8 Mean corpuscular volume; LUSC cis rs6674176 0.518 rs917294 chr1:44249485 A/G cg12908607 chr1:44402522 ARTN -0.4 -6.08 -0.32 3.33e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6547741 0.935 rs12615690 chr2:27851120 T/C cg27432699 chr2:27873401 GPN1 0.83 15.76 0.65 3.06e-42 Oral cavity cancer; LUSC cis rs950027 0.620 rs1145084 chr15:45675440 G/A cg26924012 chr15:45694286 SPATA5L1 0.78 12.31 0.56 5.66e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs2219968 0.923 rs35703732 chr8:78953269 C/T cg00738934 chr8:78996279 NA 0.34 6.08 0.32 3.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2404602 0.669 rs12438540 chr15:76943213 C/G cg23625390 chr15:77176239 SCAPER 0.46 7.02 0.36 1.22e-11 Blood metabolite levels; LUSC cis rs12286929 0.644 rs9645660 chr11:115081563 C/T cg04055981 chr11:115044050 NA 0.39 6.96 0.36 1.77e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7107174 1.000 rs57738705 chr11:77994489 A/G cg02023728 chr11:77925099 USP35 0.49 7.07 0.36 9.23e-12 Testicular germ cell tumor; LUSC cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg18132916 chr6:79620363 NA -0.38 -5.84 -0.3 1.23e-8 Intelligence (multi-trait analysis); LUSC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -6.06 -0.31 3.59e-9 Intelligence (multi-trait analysis); LUSC cis rs11955175 1.000 rs75929994 chr5:40821816 T/C cg04002187 chr5:40835754 RPL37 0.71 5.84 0.3 1.27e-8 Bipolar disorder and schizophrenia; LUSC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg08499158 chr17:42289980 UBTF 0.5 7.95 0.4 2.81e-14 Total body bone mineral density; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg15783272 chr19:50980145 C19orf63;FAM71E1 0.39 6.15 0.32 2.17e-9 Mosquito bite size; LUSC trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -13.7 -0.6 3.38e-34 Coronary artery disease; LUSC cis rs56235845 0.694 rs11738681 chr5:176761535 A/G cg17261708 chr5:176794207 RGS14 0.34 6.05 0.31 3.79e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg14784868 chr12:69753453 YEATS4 0.7 11.44 0.53 8.42e-26 Blood protein levels; LUSC cis rs9300255 0.602 rs1569068 chr12:123632276 A/G cg13010344 chr12:123464640 ARL6IP4 0.4 5.93 0.31 7.51e-9 Neutrophil percentage of white cells; LUSC trans rs2288327 1.000 rs890578 chr2:179414633 G/T cg14011486 chr1:26737247 LIN28 0.47 6.13 0.32 2.47e-9 Atrial fibrillation; LUSC cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.15 16.21 0.66 5.28e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7680126 0.596 rs10805364 chr4:10275518 A/G cg26043149 chr18:55253948 FECH -0.49 -6.24 -0.32 1.3e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; LUSC cis rs12586317 0.620 rs2295104 chr14:35579927 A/G cg16230307 chr14:35515116 FAM177A1 -0.8 -10.12 -0.48 3.56e-21 Psoriasis; LUSC cis rs66887589 0.870 rs59590064 chr4:120539753 T/C cg24375607 chr4:120327624 NA -0.47 -7.24 -0.37 3.13e-12 Diastolic blood pressure; LUSC cis rs2242194 0.816 rs6671688 chr1:154994265 T/C cg09359103 chr1:154839909 KCNN3 -0.43 -8.18 -0.41 5.91e-15 Schizophrenia; LUSC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg08045932 chr20:61659980 NA 0.58 10.21 0.49 1.78e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs909341 0.909 rs1291207 chr20:62329412 G/A cg09650180 chr20:62225654 GMEB2 -0.46 -5.98 -0.31 5.88e-9 Atopic dermatitis; LUSC cis rs2346177 0.875 rs12986585 chr2:46644121 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.55 -8.59 -0.43 3.29e-16 HDL cholesterol; LUSC cis rs3820068 0.532 rs1547034 chr1:15919049 T/A cg24675056 chr1:15929824 NA 0.43 7.41 0.38 1.02e-12 Systolic blood pressure; LUSC cis rs4704187 0.663 rs4704189 chr5:74487375 A/C cg03227963 chr5:74354835 NA 0.3 6.54 0.34 2.32e-10 Response to amphetamines; LUSC cis rs8017423 0.647 rs12895269 chr14:90822430 T/C cg04374321 chr14:90722782 PSMC1 -0.42 -6.39 -0.33 5.65e-10 Mortality in heart failure; LUSC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg22433210 chr17:43662623 NA -0.72 -10.47 -0.5 2.31e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs6951245 1.000 rs78523927 chr7:1089458 T/C cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12900413 0.603 rs12905689 chr15:90301343 G/A cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.91e-9 Menopause (age at onset); LUSC cis rs12908161 1.000 rs12911736 chr15:85240008 A/G cg17173187 chr15:85201210 NMB 0.51 9.66 0.47 1.24e-19 Schizophrenia; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg22638593 chr5:131593259 PDLIM4 0.49 7.33 0.37 1.69e-12 Acylcarnitine levels; LUSC cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg23992470 chr4:843637 GAK 0.62 6.16 0.32 2.11e-9 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs7584330 0.554 rs74001383 chr2:238424418 T/C cg14458575 chr2:238380390 NA 0.45 5.86 0.31 1.1e-8 Prostate cancer; LUSC cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.37 0.56 3.34e-29 Colonoscopy-negative controls vs population controls; LUSC cis rs6931421 0.800 rs12662365 chr6:80905389 T/A cg08355045 chr6:80787529 NA 0.58 9.13 0.45 6.74e-18 Sitting height ratio; LUSC cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg17063962 chr7:91808500 NA -0.56 -8.65 -0.43 2.28e-16 Breast cancer; LUSC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg06808227 chr14:105710500 BRF1 -0.7 -11.14 -0.52 1.03e-24 Mean platelet volume;Platelet distribution width; LUSC cis rs4409675 0.597 rs1467464 chr1:28211650 T/C cg23691781 chr1:28212827 C1orf38 0.32 7.6 0.38 3.06e-13 Corneal astigmatism; LUSC cis rs34375054 0.573 rs12579211 chr12:125647752 C/T cg25124228 chr12:125621409 AACS -0.52 -6.75 -0.35 6.75e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7605827 0.626 rs2031011 chr2:15548390 A/G cg19274914 chr2:15703543 NA 0.42 7.51 0.38 5.6e-13 Educational attainment (years of education); LUSC trans rs11696501 0.739 rs2235600 chr20:44238299 T/G cg03272292 chr12:48577362 C12orf68 0.53 6.29 0.33 1.01e-9 Brain structure; LUSC cis rs826838 1.000 rs11168367 chr12:38913397 T/G cg13010199 chr12:38710504 ALG10B 0.68 11.24 0.52 4.28e-25 Heart rate; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg08859206 chr1:53392774 SCP2 -0.67 -12.74 -0.57 1.4e-30 Monocyte count; LUSC cis rs17253792 0.822 rs10083431 chr14:56068348 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg22823121 chr1:150693482 HORMAD1 0.6 9.28 0.45 2.21e-18 Tonsillectomy; LUSC cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg00071950 chr4:10020882 SLC2A9 0.64 10.93 0.51 5.65e-24 Bone mineral density; LUSC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg23172400 chr8:95962367 TP53INP1 -0.35 -6.5 -0.34 2.85e-10 Type 2 diabetes; LUSC cis rs4319547 0.695 rs11058034 chr12:122894936 G/T cg23029597 chr12:123009494 RSRC2 0.76 9.32 0.45 1.64e-18 Body mass index; LUSC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg11764359 chr7:65958608 NA 0.62 9.47 0.46 5.16e-19 Calcium levels; LUSC cis rs9399135 0.967 rs4376365 chr6:135307740 T/C cg22676075 chr6:135203613 NA 0.47 7.31 0.37 1.95e-12 Red blood cell count; LUSC cis rs72781680 0.950 rs72796343 chr2:24147631 G/A cg08917208 chr2:24149416 ATAD2B 1.01 10.61 0.5 7.29e-23 Lymphocyte counts; LUSC cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg11266682 chr4:10021025 SLC2A9 0.6 10.9 0.51 7.13e-24 Bone mineral density; LUSC cis rs6430585 0.527 rs60966546 chr2:136401843 C/T cg07169764 chr2:136633963 MCM6 1.04 13.69 0.6 3.6e-34 Corneal structure; LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03352830 chr11:487213 PTDSS2 0.69 8.67 0.43 1.9e-16 Body mass index; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg20821713 chr7:1055600 C7orf50 -0.38 -5.83 -0.3 1.29e-8 Longevity;Endometriosis; LUSC cis rs1018836 0.923 rs6986001 chr8:91650205 T/C cg16814680 chr8:91681699 NA -0.81 -13.69 -0.6 3.55e-34 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs11077998 0.840 rs9910991 chr17:80481193 G/A cg10255544 chr17:80519551 FOXK2 0.41 6.57 0.34 1.92e-10 Reticulocyte fraction of red cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11276198 chr12:25404189 KRAS -0.42 -6.37 -0.33 6.13e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs921968 0.643 rs659185 chr2:219335935 C/T cg02176678 chr2:219576539 TTLL4 0.6 10.75 0.51 2.5e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg02079420 chr8:82753780 SNX16 -0.42 -7.2 -0.37 4.14e-12 Diastolic blood pressure; LUSC cis rs7572644 0.766 rs11902158 chr2:28086765 A/G cg27432699 chr2:27873401 GPN1 0.51 6.42 0.33 4.57e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg18357526 chr6:26021779 HIST1H4A 0.41 6.65 0.34 1.2e-10 Intelligence (multi-trait analysis); LUSC cis rs4776059 1.000 rs4776068 chr15:52947401 G/A cg22715398 chr15:52968154 KIAA1370 -0.69 -9.99 -0.48 9.68e-21 Schizophrenia; LUSC cis rs6424115 0.830 rs1130320 chr1:24200606 A/G cg10978503 chr1:24200527 CNR2 0.54 13.3 0.59 1.11e-32 Immature fraction of reticulocytes; LUSC cis rs500891 0.533 rs6903322 chr6:84168968 C/T cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs7246967 0.673 rs28649847 chr19:22811540 G/T cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs6424115 0.830 rs3003333 chr1:24194014 A/T cg15997130 chr1:24165203 NA -0.5 -8.21 -0.41 4.77e-15 Immature fraction of reticulocytes; LUSC cis rs11650494 0.908 rs79768864 chr17:47446968 C/A cg08112188 chr17:47440006 ZNF652 1.39 11.33 0.53 2.06e-25 Prostate cancer; LUSC cis rs6701037 1.000 rs6681020 chr1:175125264 G/A cg00321850 chr1:175162397 KIAA0040 -0.4 -6.9 -0.35 2.55e-11 Alcohol dependence; LUSC cis rs258324 0.790 rs258318 chr16:89732050 T/C cg26513180 chr16:89883248 FANCA -0.75 -6.74 -0.35 7.13e-11 Height; LUSC cis rs2564921 0.570 rs3821831 chr3:52853401 C/T cg11645453 chr3:52864694 ITIH4 -0.27 -6.08 -0.32 3.35e-9 Height; LUSC cis rs11264799 0.520 rs849828 chr1:157545047 A/G cg18268488 chr1:157545234 FCRL4 0.39 7.69 0.39 1.62e-13 IgA nephropathy; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg21724239 chr8:58056113 NA 0.78 8.56 0.42 4.04e-16 Developmental language disorder (linguistic errors); LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.74 0.35 7.12e-11 Platelet count; LUSC trans rs11098499 0.863 rs9884402 chr4:120489982 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.73 0.35 7.39e-11 Corneal astigmatism; LUSC cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg08807101 chr21:30365312 RNF160 0.65 9.74 0.47 6.74e-20 Selective IgA deficiency; LUSC cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs806215 1.000 rs806216 chr7:127237862 C/A cg25922125 chr7:127225783 GCC1 -0.58 -7.05 -0.36 1.03e-11 Type 2 diabetes; LUSC trans rs8072100 0.840 rs4968319 chr17:45464967 A/G cg04995722 chr7:26192034 NFE2L3 -0.38 -6.28 -0.32 1.06e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs13233308 0.868 rs7779623 chr7:87391761 A/G cg22633988 chr4:77610603 SHROOM3 -0.42 -6.26 -0.32 1.18e-9 Schizophrenia; LUSC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg17252645 chr8:143867129 LY6D 0.37 6.49 0.33 3.08e-10 Urinary tract infection frequency; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.61 0.43 2.84e-16 Prudent dietary pattern; LUSC trans rs573521 0.584 rs1144397 chr11:102682285 T/G cg19721115 chr12:70759665 KCNMB4 -0.41 -5.99 -0.31 5.3300000000000004e-09 Cerebrospinal fluid levels of Alzheimer's disease-related proteins; LUSC cis rs2439831 0.681 rs2278859 chr15:43632960 A/C cg02155558 chr15:43621948 ADAL;LCMT2 1.09 15.27 0.64 2.72e-40 Lung cancer in ever smokers; LUSC cis rs9653442 0.527 rs4850923 chr2:100782256 A/C cg07810366 chr2:100720526 AFF3 -0.45 -7.63 -0.39 2.44e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2637266 1.000 rs12251543 chr10:78345465 G/A cg18941641 chr10:78392320 NA 0.38 7.07 0.36 8.85e-12 Pulmonary function; LUSC cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg04455712 chr21:45112962 RRP1B 0.47 9.12 0.45 7.06e-18 Mean corpuscular volume; LUSC cis rs9902453 0.691 rs140701 chr17:28538532 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.5 7.47 0.38 6.86e-13 Coffee consumption (cups per day); LUSC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg26119090 chr2:26468346 HADHA;HADHB 0.86 9.88 0.48 2.32e-20 Gut microbiome composition (summer); LUSC cis rs10752881 1.000 rs10737237 chr1:182989269 A/G ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.94e-22 Colorectal cancer; LUSC cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.56 0.42 4.21e-16 Motion sickness; LUSC cis rs950881 0.932 rs13408569 chr2:102955056 G/C cg20060108 chr2:102954350 IL1RL1 0.45 5.9 0.31 8.86e-9 Allergy; LUSC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg18479299 chr3:125709523 NA -0.5 -5.77 -0.3 1.82e-8 Blood pressure (smoking interaction); LUSC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg14668632 chr7:2872130 GNA12 -0.46 -6.96 -0.36 1.85e-11 Height; LUSC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg11366901 chr6:160182831 ACAT2 0.93 13.08 0.58 7.66e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg12463550 chr7:65579703 CRCP 0.51 7.33 0.37 1.74e-12 Aortic root size; LUSC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.94 -0.31 6.98e-9 Tonsillectomy; LUSC cis rs7739264 0.602 rs1121384 chr6:19771507 A/G cg02404759 chr6:19790362 NA -0.43 -6.7 -0.34 9.02e-11 Endometriosis; LUSC cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg00677455 chr12:58241039 CTDSP2 0.61 9.06 0.44 1.15e-17 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg25427524 chr10:38739819 LOC399744 -0.72 -13.38 -0.59 5.32e-33 Extrinsic epigenetic age acceleration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12958836 chr12:8185024 FOXJ2 0.39 6.29 0.33 9.74e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12421382 0.558 rs12422001 chr11:109391880 A/G cg16359550 chr11:109292809 C11orf87 0.37 6.33 0.33 7.89e-10 Schizophrenia; LUSC cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg04362960 chr10:104952993 NT5C2 0.62 9.83 0.47 3.51e-20 Arsenic metabolism; LUSC cis rs35264875 0.950 rs35337391 chr11:68854012 A/G cg02660097 chr11:68866761 NA 0.44 6.27 0.32 1.11e-9 Blond vs. brown hair color; LUSC cis rs2832077 0.943 rs2832097 chr21:30173340 A/T cg24692254 chr21:30365293 RNF160 0.55 7.04 0.36 1.08e-11 Cognitive test performance; LUSC cis rs7119 0.667 rs1058129 chr15:77905661 A/G cg27398640 chr15:77910606 LINGO1 0.38 8.79 0.43 7.98e-17 Type 2 diabetes; LUSC trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg15704280 chr7:45808275 SEPT13 0.86 11.2 0.52 6.15e-25 Coronary artery disease; LUSC cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg27446573 chr6:127587934 RNF146 0.67 10.12 0.48 3.54e-21 Breast cancer; LUSC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg27121462 chr16:89883253 FANCA -0.38 -5.97 -0.31 5.97e-9 Vitiligo; LUSC cis rs6582630 0.599 rs8175936 chr12:38426315 C/G cg26384229 chr12:38710491 ALG10B -0.55 -8.22 -0.41 4.49e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs6542838 0.641 rs11123756 chr2:99508012 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.45 6.08 0.32 3.33e-9 Fear of minor pain; LUSC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg12935359 chr14:103987150 CKB -0.62 -10.17 -0.49 2.46e-21 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg13683864 chr3:40499215 RPL14 -1.13 -21.27 -0.76 4.37e-64 Renal cell carcinoma; LUSC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg06238570 chr21:40685208 BRWD1 0.56 8.49 0.42 7.07e-16 Cognitive function; LUSC cis rs12545109 0.876 rs1992120 chr8:57337112 G/A cg09654669 chr8:57350985 NA -0.59 -7.86 -0.4 5.21e-14 Obesity-related traits; LUSC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg06808227 chr14:105710500 BRF1 0.67 10.78 0.51 1.94e-23 Mean platelet volume;Platelet distribution width; LUSC cis rs9976767 0.608 rs9784208 chr21:43824986 A/G cg23042151 chr21:43824109 UBASH3A -0.34 -6.74 -0.35 7.01e-11 Type 1 diabetes; LUSC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg09165964 chr15:75287851 SCAMP5 -1.17 -19.43 -0.73 8.65e-57 Blood trace element (Zn levels); LUSC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg21970626 chr13:21893289 NA -0.53 -9.75 -0.47 6.47e-20 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7828089 0.582 rs13259873 chr8:22266292 C/T cg12081754 chr8:22256438 SLC39A14 0.79 12.61 0.57 4.49e-30 Verbal declarative memory; LUSC cis rs7804356 1.000 rs17315775 chr7:26860134 A/G cg03456212 chr7:26904342 SKAP2 -0.52 -6.0 -0.31 5.12e-9 Type 1 diabetes; LUSC trans rs7824557 0.564 rs2572395 chr8:11235360 A/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.52 -0.38 5.11e-13 Retinal vascular caliber; LUSC cis rs12681287 0.640 rs10086340 chr8:87446789 G/T cg27223183 chr8:87520930 FAM82B -0.53 -7.16 -0.36 5.17e-12 Caudate activity during reward; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16401290 chr5:79950120 MSH3;DHFR -0.43 -6.42 -0.33 4.75e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4908769 0.624 rs2120461 chr1:8447722 C/T cg00546117 chr1:8445545 RERE 0.3 6.13 0.32 2.51e-9 Allergy; LUSC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg12927641 chr6:109611667 NA -0.42 -7.33 -0.37 1.7e-12 Reticulocyte fraction of red cells; LUSC cis rs6500602 0.702 rs11076834 chr16:4549583 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.48 6.35 0.33 7.01e-10 Schizophrenia; LUSC cis rs17345786 0.906 rs72946021 chr3:101250008 T/G cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.45 6.05 0.31 3.92e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs11166629 1.000 rs935119 chr8:135638353 C/T cg27224718 chr8:135614730 ZFAT -0.66 -11.24 -0.52 4.58e-25 Smoking quantity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19442730 chr13:73634476 KLF5 0.44 6.87 0.35 3.19e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg06877462 chr1:205807181 PM20D1 0.5 9.01 0.44 1.67e-17 Menarche (age at onset); LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.16 -0.36 5.18e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg03806693 chr22:41940476 POLR3H 1.0 14.45 0.62 4.19e-37 Vitiligo; LUSC cis rs889512 0.642 rs13337017 chr16:75272367 C/T cg04987608 chr16:75300043 BCAR1 -0.5 -5.72 -0.3 2.41e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 8.18 0.41 5.92e-15 Body mass index (adult); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17772535 chr12:65153236 GNS -0.41 -6.12 -0.32 2.56e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg21385522 chr1:16154831 NA -0.73 -11.47 -0.53 6.55e-26 Dilated cardiomyopathy; LUSC cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg06784218 chr1:46089804 CCDC17 -0.57 -11.33 -0.53 2.14e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg06784218 chr1:46089804 CCDC17 0.49 9.61 0.47 1.83e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7903847 0.642 rs7088410 chr10:99135539 G/T cg08345082 chr10:99160200 RRP12 -0.38 -7.74 -0.39 1.16e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs11098499 0.690 rs34818745 chr4:120257055 T/C cg09307838 chr4:120376055 NA 0.8 11.84 0.54 3.08e-27 Corneal astigmatism; LUSC cis rs9399135 1.000 rs9399135 chr6:135368314 G/A cg24558204 chr6:135376177 HBS1L 0.58 8.7 0.43 1.58e-16 Red blood cell count; LUSC cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg11584989 chr19:19387371 SF4 0.56 6.53 0.34 2.46e-10 Bipolar disorder; LUSC cis rs4499344 0.730 rs8103269 chr19:33097503 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.66 0.57 2.92e-30 Mean platelet volume; LUSC cis rs7824557 0.767 rs4559208 chr8:11153925 C/G cg21775007 chr8:11205619 TDH 0.71 11.81 0.54 3.78e-27 Retinal vascular caliber; LUSC cis rs7091068 0.671 rs588912 chr10:95402929 T/C cg20715218 chr10:95462985 C10orf4 -0.63 -7.4 -0.38 1.1e-12 Urinary tract infection frequency; LUSC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg24531977 chr5:56204891 C5orf35 0.89 14.21 0.61 3.61e-36 Initial pursuit acceleration; LUSC cis rs208515 0.592 rs10944862 chr6:66674215 C/T cg07460842 chr6:66804631 NA 1.05 14.32 0.62 1.33e-36 Exhaled nitric oxide levels; LUSC cis rs1003719 0.680 rs3992 chr21:38505969 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs7829975 0.606 rs7819827 chr8:8797055 G/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.85 -0.35 3.59e-11 Mood instability; LUSC trans rs7944735 0.507 rs10838802 chr11:48102478 A/G cg15704280 chr7:45808275 SEPT13 0.58 7.33 0.37 1.78e-12 Intraocular pressure; LUSC cis rs11971779 0.648 rs59791374 chr7:139116962 C/T cg07862535 chr7:139043722 LUC7L2 0.6 7.62 0.39 2.56e-13 Diisocyanate-induced asthma; LUSC cis rs367943 0.966 rs348932 chr5:112812457 G/A cg12552261 chr5:112820674 MCC -0.43 -6.95 -0.36 1.98e-11 Type 2 diabetes; LUSC cis rs2730245 0.527 rs1188971 chr7:158664463 G/T cg11984989 chr7:158649758 WDR60 1.12 13.38 0.59 5.4e-33 Height; LUSC cis rs8014204 0.747 rs2070598 chr14:75360906 C/T cg06637938 chr14:75390232 RPS6KL1 -0.57 -9.1 -0.45 8.48e-18 Caffeine consumption; LUSC cis rs10761482 0.813 rs4336985 chr10:62101374 C/A cg18175470 chr10:62150864 ANK3 -0.52 -7.44 -0.38 8.5e-13 Schizophrenia; LUSC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg07701084 chr6:150067640 NUP43 0.56 8.84 0.44 5.69e-17 Lung cancer; LUSC cis rs1580019 0.520 rs6945238 chr7:32646096 C/T cg07520158 chr7:32535189 LSM5;AVL9 -0.47 -5.65 -0.3 3.42e-8 Cognitive ability; LUSC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg07606381 chr6:8435919 SLC35B3 0.74 12.58 0.57 5.44e-30 Motion sickness; LUSC cis rs4319547 0.695 rs10773152 chr12:122910180 T/C cg23029597 chr12:123009494 RSRC2 -0.73 -9.02 -0.44 1.52e-17 Body mass index; LUSC cis rs10450586 0.863 rs7125719 chr11:27288359 G/C cg08958251 chr11:27270390 NA 0.34 5.65 0.3 3.4e-8 Total body bone mineral density; LUSC cis rs6835098 0.962 rs4377567 chr4:174083590 C/G cg08422745 chr4:174089978 GALNT7 0.84 14.04 0.61 1.57e-35 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs10089 0.953 rs1985268 chr5:127375931 T/C cg19767477 chr5:127420684 SLC12A2 -0.4 -5.74 -0.3 2.12e-8 Ileal carcinoids; LUSC cis rs4730250 0.707 rs1981696 chr7:106794100 C/T cg02696742 chr7:106810147 HBP1 0.61 8.93 0.44 2.87e-17 Osteoarthritis; LUSC cis rs9325144 0.505 rs10785560 chr12:38636622 C/T cg13010199 chr12:38710504 ALG10B 0.61 9.36 0.46 1.25e-18 Morning vs. evening chronotype; LUSC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg19748678 chr4:122722346 EXOSC9 0.5 7.58 0.38 3.54e-13 Type 2 diabetes; LUSC cis rs8060686 0.641 rs7192187 chr16:68132109 T/C cg04539111 chr16:67997858 SLC12A4 -0.42 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg00310523 chr12:86230176 RASSF9 0.55 10.26 0.49 1.21e-21 Major depressive disorder; LUSC cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg22508957 chr16:3507546 NAT15 -0.4 -5.74 -0.3 2.14e-8 Body mass index (adult); LUSC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg03233332 chr7:66118400 NA -0.4 -6.02 -0.31 4.58e-9 Aortic root size; LUSC trans rs10221833 0.602 rs355881 chr2:165633716 C/G cg26993132 chr16:89239499 CDH15 0.31 5.97 0.31 6.09e-9 Response to statin therapy; LUSC cis rs2898290 0.578 rs34163377 chr8:11450213 C/G cg27411982 chr8:10470053 RP1L1 0.38 5.81 0.3 1.48e-8 Systolic blood pressure; LUSC trans rs2739330 0.828 rs5760108 chr22:24252668 G/T cg06437703 chr8:37914619 EIF4EBP1 -0.54 -8.39 -0.42 1.43e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs950893 0.597 rs2942219 chr8:23439308 A/G cg20845639 chr8:23430886 NA 0.3 5.67 0.3 3.09e-8 Mean corpuscular hemoglobin; LUSC cis rs4363385 0.747 rs6678107 chr1:152966818 T/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.66 -0.39 2.03e-13 Inflammatory skin disease; LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg25036284 chr2:26402008 FAM59B 0.78 11.06 0.52 1.94e-24 Gut microbiome composition (summer); LUSC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg08859206 chr1:53392774 SCP2 0.46 7.75 0.39 1.1e-13 Monocyte count; LUSC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg12365402 chr11:9010492 NRIP3 -0.52 -10.03 -0.48 7.49e-21 Hemoglobin concentration; LUSC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg05585544 chr11:47624801 NA 0.41 7.25 0.37 2.92e-12 Subjective well-being; LUSC cis rs1355223 0.902 rs11605785 chr11:34751387 G/A cg11058730 chr11:34937778 PDHX;APIP -0.4 -5.65 -0.3 3.38e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg18479299 chr3:125709523 NA -0.5 -6.11 -0.32 2.72e-9 Blood pressure (smoking interaction); LUSC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg00908189 chr16:619842 PIGQ 0.68 10.85 0.51 1.11e-23 Height; LUSC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg18904891 chr8:8559673 CLDN23 0.56 7.69 0.39 1.68e-13 Obesity-related traits; LUSC cis rs4423214 0.840 rs1792226 chr11:71176574 C/T cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg18196295 chr10:418757 DIP2C 0.49 8.06 0.4 1.38e-14 Psychosis in Alzheimer's disease; LUSC cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg03146154 chr1:46216737 IPP -0.56 -8.39 -0.42 1.39e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs11264213 0.901 rs72661623 chr1:36398368 G/A cg05872835 chr6:75796125 COL12A1 0.51 5.97 0.31 5.97e-9 Schizophrenia; LUSC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.38 -0.33 5.74e-10 Breast cancer; LUSC cis rs10979 0.964 rs12526234 chr6:143898680 A/T cg25407410 chr6:143891975 LOC285740 -0.74 -11.79 -0.54 4.66e-27 Hypospadias; LUSC cis rs864537 0.622 rs2949661 chr1:167424924 C/T cg22356347 chr1:167427500 CD247 -0.34 -7.73 -0.39 1.3e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18099408 chr3:52552593 STAB1 0.37 6.57 0.34 1.96e-10 Electroencephalogram traits; LUSC cis rs929354 0.739 rs12533082 chr7:157014172 T/A cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.74e-19 Body mass index; LUSC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg19678392 chr7:94953810 PON1 -0.37 -5.98 -0.31 5.89e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg10523679 chr1:76189770 ACADM -0.88 -14.16 -0.61 5.75e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1577917 0.958 rs12196230 chr6:86519960 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.47 -0.42 8.08e-16 Response to antipsychotic treatment; LUSC cis rs9811920 0.809 rs923472 chr3:99758029 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.53 -0.34 2.4e-10 Axial length; LUSC cis rs2607426 0.579 rs2644917 chr19:41287007 G/T cg05508168 chr19:41255947 C19orf54;SNRPA 0.92 7.26 0.37 2.8e-12 Blood protein levels; LUSC cis rs713477 0.967 rs4898865 chr14:55910998 G/A cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg06238570 chr21:40685208 BRWD1 0.52 7.96 0.4 2.75e-14 Cognitive function; LUSC cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.42 -6.74 -0.35 6.92e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11890956 chr21:40555474 PSMG1 -0.75 -11.65 -0.54 1.47e-26 Menarche (age at onset); LUSC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg14004847 chr7:1930337 MAD1L1 -0.58 -8.83 -0.44 5.93e-17 Schizophrenia; LUSC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg23711669 chr6:146136114 FBXO30 -0.91 -17.6 -0.69 1.62e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 1.000 rs10234434 chr7:91673308 A/T cg17063962 chr7:91808500 NA 0.59 9.16 0.45 5.16e-18 Breast cancer; LUSC cis rs10979 0.597 rs9403515 chr6:143908013 A/G cg25407410 chr6:143891975 LOC285740 -0.65 -8.19 -0.41 5.6e-15 Hypospadias; LUSC cis rs7726839 0.718 rs6887972 chr5:597274 C/G cg09021430 chr5:549028 NA -0.6 -9.41 -0.46 8.29e-19 Obesity-related traits; LUSC cis rs10746514 0.841 rs9725652 chr1:232245997 T/A cg09506761 chr1:232265262 NA 0.52 8.41 0.42 1.23e-15 Response to statin therapy; LUSC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg07701084 chr6:150067640 NUP43 0.55 8.34 0.42 1.96e-15 Lung cancer; LUSC cis rs9611565 0.568 rs2413656 chr22:42129357 G/T cg03806693 chr22:41940476 POLR3H 0.85 12.55 0.57 7.53e-30 Vitiligo; LUSC cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg01884057 chr2:25150051 NA 0.44 10.18 0.49 2.23e-21 Body mass index; LUSC cis rs9323205 0.861 rs56137183 chr14:51693463 C/A cg23942311 chr14:51606299 NA -0.47 -9.35 -0.46 1.33e-18 Cancer; LUSC cis rs11122272 0.766 rs2790867 chr1:231548059 A/C cg06096015 chr1:231504339 EGLN1 -0.53 -9.18 -0.45 4.66e-18 Hemoglobin concentration; LUSC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg12463550 chr7:65579703 CRCP 0.45 6.76 0.35 6.19e-11 Aortic root size; LUSC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg02569458 chr12:86230093 RASSF9 0.58 9.8 0.47 4.13e-20 Major depressive disorder; LUSC cis rs4919694 0.611 rs77328741 chr10:105066314 T/C cg04362960 chr10:104952993 NT5C2 1.04 10.73 0.51 2.73e-23 Arsenic metabolism; LUSC cis rs2658782 0.547 rs10765602 chr11:93048165 G/T cg15737290 chr11:93063684 CCDC67 0.9 13.88 0.6 6.67e-35 Pulmonary function decline; LUSC cis rs2737618 0.651 rs2249156 chr1:200083541 A/G cg21825944 chr1:200113062 NR5A2 0.3 5.66 0.3 3.24e-8 Uric acid levels; LUSC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg11941060 chr3:133502564 NA -0.41 -5.88 -0.31 1.02e-8 Iron status biomarkers; LUSC cis rs6138458 0.961 rs11700073 chr20:24975215 C/G cg26195577 chr20:24973756 C20orf3 1.1 17.95 0.7 6.25e-51 Blood protein levels; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg04775059 chr7:64541387 NA -0.49 -7.39 -0.38 1.15e-12 Calcium levels; LUSC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg11764359 chr7:65958608 NA 0.7 10.85 0.51 1.03e-23 Aortic root size; LUSC cis rs6942756 1.000 rs11769045 chr7:128895335 A/G cg02491457 chr7:128862824 NA -0.52 -7.48 -0.38 6.68e-13 White matter hyperintensity burden; LUSC cis rs7465272 0.530 rs10103161 chr8:143738571 A/G cg24634471 chr8:143751801 JRK 0.5 7.17 0.37 4.9e-12 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.94e-10 Menopause (age at onset); LUSC cis rs1878931 0.507 rs11648783 chr16:3406626 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.51 6.93 0.35 2.19e-11 Body mass index (adult); LUSC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC cis rs62400317 0.826 rs12213735 chr6:45152848 C/T cg20913747 chr6:44695427 NA 0.46 7.44 0.38 8.72e-13 Total body bone mineral density; LUSC cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg21573476 chr21:45109991 RRP1B -0.42 -6.63 -0.34 1.39e-10 Mean corpuscular volume; LUSC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg16680214 chr1:154839983 KCNN3 0.58 11.37 0.53 1.5e-25 Prostate cancer; LUSC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg01657329 chr11:68192670 LRP5 -0.45 -7.23 -0.37 3.34e-12 Total body bone mineral density; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg02033258 chr5:131593261 PDLIM4 0.4 5.74 0.3 2.11e-8 Acylcarnitine levels; LUSC cis rs75804782 0.521 rs55713398 chr2:239419933 A/G cg18131467 chr2:239335373 ASB1 -0.72 -6.3 -0.33 9.19e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg14844989 chr11:31128820 NA -0.38 -5.88 -0.31 9.81e-9 Red blood cell count; LUSC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg22437258 chr11:111473054 SIK2 0.47 6.25 0.32 1.22e-9 Primary sclerosing cholangitis; LUSC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.76 -0.39 1.06e-13 Mean platelet volume;Platelet distribution width; LUSC trans rs6502050 0.835 rs8080423 chr17:80102279 A/G cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.3e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs858239 0.601 rs10255228 chr7:23158863 G/T cg23682824 chr7:23144976 KLHL7 0.4 5.88 0.31 1.02e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs11252926 0.800 rs2209625 chr10:747115 A/C cg16386425 chr10:429943 DIP2C 0.39 5.75 0.3 2.05e-8 Psychosis in Alzheimer's disease; LUSC cis rs72781680 0.898 rs56216411 chr2:23934533 G/A cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.48e-12 Lymphocyte counts; LUSC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg04414720 chr1:150670196 GOLPH3L -0.43 -6.57 -0.34 1.98e-10 Tonsillectomy; LUSC cis rs4478858 0.746 rs7520468 chr1:31688812 G/A cg00250761 chr1:31883323 NA 0.36 9.37 0.46 1.1e-18 Alcohol dependence; LUSC cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg06462663 chr19:18546047 ISYNA1 0.45 7.88 0.4 4.81e-14 Breast cancer; LUSC cis rs7100689 0.784 rs4258322 chr10:82184770 T/C cg01528321 chr10:82214614 TSPAN14 1.15 18.5 0.71 4.1e-53 Post bronchodilator FEV1; LUSC cis rs9640161 0.789 rs36035506 chr7:150057843 C/T cg10018233 chr7:150070692 REPIN1 0.37 6.49 0.33 3.07e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg01483505 chr11:975446 AP2A2 0.42 5.9 0.31 9.14e-9 Alzheimer's disease (late onset); LUSC cis rs5758659 1.000 rs134873 chr22:42657566 T/G cg15557168 chr22:42548783 NA -0.43 -7.26 -0.37 2.79e-12 Cognitive function; LUSC trans rs7939886 0.920 rs12417606 chr11:55750479 C/T cg03929089 chr4:120376271 NA 0.79 6.5 0.34 2.94e-10 Myopia (pathological); LUSC cis rs2354432 0.505 rs3737845 chr1:146724408 A/G cg25205988 chr1:146714368 CHD1L 0.99 9.19 0.45 4.16e-18 Mitochondrial DNA levels; LUSC trans rs3733585 0.699 rs4515163 chr4:9959603 C/T cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg26513180 chr16:89883248 FANCA 0.9 17.39 0.69 1.13e-48 Vitiligo; LUSC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00934597 chr7:893267 UNC84A -0.48 -7.18 -0.37 4.55e-12 Perceived unattractiveness to mosquitoes; LUSC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg00745463 chr17:30367425 LRRC37B -0.87 -10.23 -0.49 1.46e-21 Hip circumference adjusted for BMI; LUSC cis rs950169 0.922 rs11633075 chr15:85113972 C/A cg17507749 chr15:85114479 UBE2QP1 0.71 9.37 0.46 1.13e-18 Schizophrenia; LUSC cis rs4843747 0.671 rs9921236 chr16:88117015 G/T cg09044154 chr16:88155775 NA -0.51 -6.97 -0.36 1.74e-11 Menopause (age at onset); LUSC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg23630131 chr7:65973040 NA 0.2 5.73 0.3 2.29e-8 Aortic root size; LUSC cis rs7824557 0.628 rs7815802 chr8:11190647 G/C cg21775007 chr8:11205619 TDH 0.8 13.52 0.59 1.64e-33 Retinal vascular caliber; LUSC cis rs2730245 0.527 rs712199 chr7:158662250 A/G cg24397884 chr7:158709396 WDR60 0.73 8.48 0.42 7.27e-16 Height; LUSC cis rs7267979 0.844 rs2424703 chr20:25270124 G/A cg14121845 chr20:25566513 NINL 0.31 5.78 0.3 1.76e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9929218 0.508 rs6499194 chr16:68744100 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.05 22.65 0.78 1.88e-69 Colorectal cancer; LUSC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg06238570 chr21:40685208 BRWD1 0.48 7.54 0.38 4.41e-13 Cognitive function; LUSC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg24881330 chr22:46731750 TRMU 0.87 10.08 0.48 4.76e-21 LDL cholesterol;Cholesterol, total; LUSC trans rs2739330 0.760 rs5751760 chr22:24243573 G/A cg06437703 chr8:37914619 EIF4EBP1 -0.6 -10.08 -0.48 4.94e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.92 0.44 3.19e-17 Prudent dietary pattern; LUSC cis rs1023500 0.573 rs133381 chr22:42470608 C/G cg15557168 chr22:42548783 NA -0.43 -6.5 -0.33 3.01e-10 Schizophrenia; LUSC trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg03929089 chr4:120376271 NA -0.77 -10.41 -0.49 3.56e-22 Coronary artery disease; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg17178900 chr1:205818956 PM20D1 0.94 18.78 0.72 3.35e-54 Menarche (age at onset); LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg03934478 chr11:495069 RNH1 0.84 9.12 0.45 7.17e-18 Body mass index; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg16393715 chr7:1948819 MAD1L1 0.39 6.51 0.34 2.82e-10 Bipolar disorder and schizophrenia; LUSC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg11494091 chr17:61959527 GH2 0.39 6.77 0.35 5.85e-11 Height; LUSC trans rs853679 0.546 rs200981 chr6:27833174 A/G cg01620082 chr3:125678407 NA -0.69 -7.08 -0.36 8.45e-12 Depression; LUSC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg04369109 chr6:150039330 LATS1 -0.57 -8.45 -0.42 9.43e-16 Lung cancer; LUSC trans rs12571093 0.803 rs36103935 chr10:70032928 A/G cg04882175 chr6:131122610 NA -0.58 -6.6 -0.34 1.65e-10 Optic nerve measurement (disc area); LUSC cis rs6547741 0.935 rs4666004 chr2:27855052 T/A cg27432699 chr2:27873401 GPN1 0.83 15.71 0.65 4.95e-42 Oral cavity cancer; LUSC cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.81 -0.35 4.48e-11 Monocyte percentage of white cells; LUSC cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg04586622 chr2:25135609 ADCY3 0.32 6.18 0.32 1.92e-9 Body mass index; LUSC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg08677398 chr8:58056175 NA 0.57 6.93 0.35 2.12e-11 Developmental language disorder (linguistic errors); LUSC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg17252645 chr8:143867129 LY6D 0.38 6.79 0.35 5.28e-11 Urinary tract infection frequency; LUSC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.8 0.3 1.5e-8 Intelligence (multi-trait analysis); LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg24675658 chr1:53192096 ZYG11B 0.62 9.91 0.48 1.78e-20 Monocyte count; LUSC cis rs763121 0.815 rs12168758 chr22:38997269 C/G cg06022373 chr22:39101656 GTPBP1 0.73 12.0 0.55 8.2e-28 Menopause (age at onset); LUSC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg25019033 chr10:957182 NA -0.53 -6.0 -0.31 5.01e-9 Eosinophil percentage of granulocytes; LUSC trans rs561341 1.000 rs548957 chr17:30302411 G/A cg20587970 chr11:113659929 NA -1.27 -17.75 -0.7 4.04e-50 Hip circumference adjusted for BMI; LUSC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg03609598 chr5:56110824 MAP3K1 -0.42 -6.25 -0.32 1.22e-9 Initial pursuit acceleration; LUSC cis rs12545109 0.800 rs2576602 chr8:57394495 C/T cg09654669 chr8:57350985 NA -0.51 -6.87 -0.35 3.1e-11 Obesity-related traits; LUSC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.71 -0.3 2.47e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg26441486 chr22:50317300 CRELD2 0.48 7.21 0.37 3.88e-12 Schizophrenia; LUSC cis rs6142102 0.961 rs6119447 chr20:32668576 A/G cg08999081 chr20:33150536 PIGU 0.35 5.88 0.31 9.75e-9 Skin pigmentation; LUSC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg00745463 chr17:30367425 LRRC37B -0.72 -8.79 -0.43 8.04e-17 Hip circumference adjusted for BMI; LUSC cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.57 11.18 0.52 7.15e-25 Hemoglobin concentration; LUSC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.56 0.34 2.06e-10 Lung cancer; LUSC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg06634786 chr22:41940651 POLR3H -0.53 -6.44 -0.33 4.05e-10 Vitiligo; LUSC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg09267113 chr7:98030324 BAIAP2L1 0.38 5.78 0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg10018233 chr7:150070692 REPIN1 0.38 6.73 0.35 7.52e-11 Blood protein levels;Circulating chemerin levels; LUSC trans rs9886428 0.967 rs10087038 chr8:14115672 A/G cg11959399 chr20:741723 C20orf54 -0.4 -6.42 -0.33 4.67e-10 IgG glycosylation; LUSC cis rs3820928 0.874 rs1054413 chr2:227867719 A/G cg11843606 chr2:227700838 RHBDD1 0.51 7.51 0.38 5.56e-13 Pulmonary function; LUSC cis rs9653442 0.900 rs6740838 chr2:100813499 T/G cg07810366 chr2:100720526 AFF3 -0.46 -7.93 -0.4 3.32e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg03388025 chr16:89894329 SPIRE2 -0.3 -6.32 -0.33 8.48e-10 Vitiligo; LUSC cis rs709400 0.663 rs17679475 chr14:103916958 A/G cg24130564 chr14:104152367 KLC1 -0.46 -6.55 -0.34 2.13e-10 Body mass index; LUSC cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.94 -0.31 7.19e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg22823121 chr1:150693482 HORMAD1 0.5 7.24 0.37 3.2e-12 Melanoma; LUSC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg25258033 chr6:167368657 RNASET2 0.49 8.12 0.41 8.86e-15 Crohn's disease; LUSC cis rs6693567 0.565 rs11205355 chr1:150252329 G/A cg15654264 chr1:150340011 RPRD2 -0.45 -7.2 -0.37 4.02e-12 Migraine; LUSC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.08 0.32 3.34e-9 Menopause (age at onset); LUSC cis rs8017423 0.933 rs7150378 chr14:90724566 G/A cg14092571 chr14:90743983 NA -0.36 -5.89 -0.31 9.58e-9 Mortality in heart failure; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg06873352 chr17:61820015 STRADA 0.74 12.84 0.57 6.03e-31 Prudent dietary pattern; LUSC cis rs1595825 0.730 rs1902248 chr2:198492598 C/T cg00982548 chr2:198649783 BOLL -0.53 -6.74 -0.35 6.92e-11 Ulcerative colitis; LUSC cis rs9905704 0.647 rs2108435 chr17:57102133 T/C cg05425664 chr17:57184151 TRIM37 0.5 7.56 0.38 3.92e-13 Testicular germ cell tumor; LUSC cis rs17818399 0.547 rs4952831 chr2:46761181 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.55 -7.06 -0.36 9.51e-12 Height; LUSC cis rs5769765 0.671 rs138817 chr22:50163058 G/A cg08270630 chr22:50330655 NA -0.37 -5.65 -0.3 3.4e-8 Schizophrenia; LUSC cis rs1997103 1.000 rs6953494 chr7:55412157 G/A cg17469321 chr7:55412551 NA 0.64 10.19 0.49 2.02e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs877282 0.898 rs11253347 chr10:765769 A/G cg17470449 chr10:769945 NA 0.53 7.09 0.36 8.21e-12 Uric acid levels; LUSC cis rs9394438 0.529 rs10947681 chr6:37547073 C/A cg00985040 chr6:37553208 NA -0.44 -9.64 -0.47 1.44e-19 IgG glycosylation; LUSC cis rs11867934 0.731 rs9908767 chr17:17005086 C/T cg26176665 chr17:16994978 MPRIP -0.45 -5.82 -0.3 1.42e-8 Diabetic retinopathy; LUSC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg13057898 chr1:3703894 LRRC47 0.5 8.97 0.44 2.17e-17 Red cell distribution width; LUSC cis rs9902453 0.874 rs7220004 chr17:28369548 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.53 -0.5 1.46e-22 Coffee consumption (cups per day); LUSC cis rs9916302 0.706 rs9646419 chr17:37597185 A/G cg07936489 chr17:37558343 FBXL20 -0.82 -9.94 -0.48 1.47e-20 Glomerular filtration rate (creatinine); LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.42e-17 Prudent dietary pattern; LUSC cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg13535736 chr9:111863775 C9orf5 -0.42 -6.69 -0.34 9.51e-11 Menarche (age at onset); LUSC trans rs1027479 0.842 rs2935794 chr8:109723537 G/C cg14904725 chr13:113777045 F10 -0.25 -6.12 -0.32 2.58e-9 Facial morphology (factor 6, height of vermillion lower lip); LUSC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg06221963 chr1:154839813 KCNN3 -0.61 -13.72 -0.6 2.81e-34 Prostate cancer; LUSC cis rs9815354 1.000 rs9867627 chr3:41795841 G/T cg03022575 chr3:42003672 ULK4 -0.56 -6.31 -0.33 8.82e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs7666738 0.753 rs17027308 chr4:99091088 T/A cg05340658 chr4:99064831 C4orf37 0.59 9.67 0.47 1.15e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs4654899 0.865 rs10916910 chr1:21283192 G/T cg01072550 chr1:21505969 NA -0.53 -7.79 -0.39 8.52e-14 Superior frontal gyrus grey matter volume; LUSC cis rs2046867 0.818 rs1502758 chr3:72865126 A/G cg25664220 chr3:72788482 NA -0.7 -11.77 -0.54 5.32e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9379945 1 rs9379945 chr6:26907831 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.45 -5.98 -0.31 5.71e-9 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg07703079 chr11:430292 ANO9 0.58 6.35 0.33 6.89e-10 Body mass index; LUSC cis rs4144743 1.000 rs34182248 chr17:45321359 T/C cg18085866 chr17:45331354 ITGB3 -0.79 -8.33 -0.41 2.06e-15 Body mass index; LUSC cis rs4974559 0.947 rs58750335 chr4:1364764 G/A cg02980000 chr4:1222292 CTBP1 0.73 6.45 0.33 3.92e-10 Systolic blood pressure; LUSC cis rs62458065 0.640 rs10241303 chr7:32534203 T/G cg20159608 chr7:32802032 NA -0.74 -9.51 -0.46 4.04e-19 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.47 -6.97 -0.36 1.71e-11 Alzheimer's disease (late onset); LUSC cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg16850897 chr7:100343110 ZAN 0.37 5.89 0.31 9.66e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg24596788 chr1:163392923 NA -0.44 -7.28 -0.37 2.38e-12 Motion sickness; LUSC cis rs2230307 0.536 rs640030 chr1:100574992 C/T cg24955406 chr1:100503596 HIAT1 -0.63 -6.68 -0.34 1.01e-10 Carotid intima media thickness; LUSC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.71 0.3 2.49e-8 Self-reported allergy; LUSC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.585 rs12999151 chr2:100939333 G/A cg12002119 chr2:101014098 CHST10 0.35 5.81 0.3 1.5e-8 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.824 rs4411469 chr15:72421689 A/G cg16672083 chr15:72433130 SENP8 -0.52 -7.55 -0.38 4.15e-13 Red blood cell count; LUSC cis rs7524258 0.900 rs12035586 chr1:7273020 C/T cg07173049 chr1:7289937 CAMTA1 -0.32 -6.56 -0.34 2.09e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg13012494 chr21:47604986 C21orf56 0.51 7.72 0.39 1.38e-13 Testicular germ cell tumor; LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg08888203 chr3:10149979 C3orf24 0.66 9.07 0.44 1.06e-17 Alzheimer's disease; LUSC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg17294928 chr15:75287854 SCAMP5 -0.76 -10.2 -0.49 1.97e-21 Blood trace element (Zn levels); LUSC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.11 0.32 2.74e-9 Personality dimensions; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20979926 chr12:112546623 NAA25 -0.47 -6.01 -0.31 4.73e-9 Bipolar disorder and schizophrenia; LUSC trans rs12692738 0.526 rs355857 chr2:165629214 A/G cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4906332 1.000 rs2065018 chr14:103879187 C/T cg04998671 chr14:104000505 TRMT61A 0.44 6.9 0.35 2.64e-11 Coronary artery disease; LUSC cis rs67478160 0.634 rs2368558 chr14:104230518 A/G cg08213375 chr14:104286397 PPP1R13B 0.47 9.18 0.45 4.76e-18 Schizophrenia; LUSC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg09021430 chr5:549028 NA -0.57 -8.25 -0.41 3.77e-15 Obesity-related traits; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.5 -7.4 -0.38 1.08e-12 Renal function-related traits (BUN); LUSC cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg13256891 chr4:100009986 ADH5 0.51 6.95 0.36 1.91e-11 Smoking initiation; LUSC cis rs7759001 0.857 rs10080555 chr6:27362866 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs34779708 0.966 rs35146199 chr10:35460939 T/C cg04310649 chr10:35416472 CREM -0.42 -6.39 -0.33 5.7e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4478137 0.931 rs11100488 chr4:164237660 C/A cg06758707 chr4:164254230 NPY1R 0.66 10.1 0.48 4.13e-21 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs7824557 0.602 rs11784544 chr8:11204503 G/C cg15556689 chr8:8085844 FLJ10661 0.49 7.18 0.37 4.43e-12 Retinal vascular caliber; LUSC cis rs6494488 0.500 rs72742921 chr15:64855556 G/A cg08069370 chr15:64387884 SNX1 -0.64 -5.73 -0.3 2.24e-8 Coronary artery disease; LUSC cis rs2898681 0.580 rs41279517 chr4:53729771 T/C cg21521518 chr4:53727714 RASL11B 0.49 6.05 0.31 3.97e-9 Optic nerve measurement (cup area); LUSC cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg03060546 chr3:49711283 APEH -0.69 -10.24 -0.49 1.42e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg11984989 chr7:158649758 WDR60 1.08 23.07 0.78 4.28e-71 Height; LUSC cis rs4285028 0.747 rs1574133 chr3:121468794 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.97 -0.58 2.02e-31 Multiple sclerosis; LUSC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.55 7.78 0.39 8.93e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs73001065 0.551 rs56397647 chr19:19642795 C/T cg03709012 chr19:19516395 GATAD2A 0.9 7.9 0.4 4.09e-14 LDL cholesterol; LUSC cis rs4363385 0.510 rs6693927 chr1:153044009 G/A cg00922841 chr1:152955080 SPRR1A -0.38 -6.39 -0.33 5.43e-10 Inflammatory skin disease; LUSC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs61931739 0.500 rs6488218 chr12:34452587 T/C cg06521331 chr12:34319734 NA -0.39 -6.37 -0.33 6.35e-10 Morning vs. evening chronotype; LUSC cis rs9457247 0.565 rs2239824 chr6:167511799 T/A cg07741184 chr6:167504864 NA 0.51 8.74 0.43 1.15e-16 Crohn's disease; LUSC cis rs2742417 0.603 rs2673062 chr3:45763635 A/G cg10512202 chr3:45649293 LIMD1 0.35 5.89 0.31 9.61e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs193541 0.593 rs1035372 chr5:122169448 C/A cg19077854 chr5:122220652 SNX24 0.37 7.83 0.39 6.46e-14 Glucose homeostasis traits; LUSC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg05855489 chr10:104503620 C10orf26 0.57 9.18 0.45 4.51e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg19435381 chr5:41870796 OXCT1 -0.46 -6.02 -0.31 4.63e-9 Cognitive function;Information processing speed; LUSC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg21856205 chr7:94953877 PON1 -0.36 -5.85 -0.3 1.19e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs12908161 1.000 rs36033486 chr15:85319692 A/G cg17507749 chr15:85114479 UBE2QP1 0.53 6.58 0.34 1.87e-10 Schizophrenia; LUSC cis rs7264396 0.635 rs6058382 chr20:34553948 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg22875332 chr1:76189707 ACADM -0.41 -6.1 -0.32 2.9e-9 Daytime sleep phenotypes; LUSC cis rs3755132 0.929 rs60269778 chr2:15753604 A/G cg12888861 chr2:15731646 DDX1 0.52 7.48 0.38 6.45e-13 Wilms tumor; LUSC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs951366 0.576 rs11240559 chr1:205709621 T/G cg14893161 chr1:205819251 PM20D1 -0.48 -6.48 -0.33 3.38e-10 Menarche (age at onset); LUSC cis rs1559088 0.847 rs2287680 chr19:33608566 A/G cg27124370 chr19:33622961 WDR88 -0.54 -7.13 -0.36 6.26e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs2840044 1.000 rs9900378 chr17:33911302 C/T cg19694781 chr19:47549865 TMEM160 0.58 9.39 0.46 9.66e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs9287719 0.967 rs7593496 chr2:10738176 A/C cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs1035144 0.506 rs2371416 chr14:81275672 A/T cg06600135 chr14:81408086 NA -0.53 -7.72 -0.39 1.33e-13 Male sexual orientation; LUSC cis rs10832963 1.000 rs2084220 chr11:18656932 C/T cg20219074 chr11:18656078 SPTY2D1 0.73 10.98 0.51 3.79e-24 Breast cancer; LUSC cis rs9788721 0.934 rs16969968 chr15:78882925 G/A cg18825076 chr15:78729989 IREB2 -0.49 -7.64 -0.39 2.28e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.69 0.47 1.02e-19 Bipolar disorder; LUSC cis rs11123610 0.520 rs13409381 chr2:3722579 A/G cg00999904 chr2:3704751 ALLC -0.42 -6.53 -0.34 2.44e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2439831 0.867 rs76542740 chr15:43891512 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.86 9.15 0.45 5.78e-18 Lung cancer in ever smokers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08486583 chr10:94333347 IDE -0.42 -6.32 -0.33 8.33e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11997175 0.545 rs4733457 chr8:33661236 G/A ch.8.33884649F chr8:33765107 NA 0.49 7.29 0.37 2.2e-12 Body mass index; LUSC trans rs800082 0.516 rs1182797 chr3:144241495 T/C cg24215973 chr2:240111563 HDAC4 0.44 6.81 0.35 4.55e-11 Smoking behavior; LUSC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg03128945 chr5:622914 CEP72 -0.46 -6.64 -0.34 1.27e-10 Obesity-related traits; LUSC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg03676636 chr4:99064102 C4orf37 0.32 7.05 0.36 1.06e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg04315214 chr1:2043799 PRKCZ 0.46 9.38 0.46 1.01e-18 Height; LUSC trans rs1376359 0.577 rs648505 chr1:103284892 G/T cg17154563 chr19:40477487 PSMC4 0.47 5.96 0.31 6.52e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC trans rs7824557 0.564 rs2572392 chr8:11235605 T/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.54 -0.34 2.27e-10 Retinal vascular caliber; LUSC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg14440974 chr22:39074834 NA -0.35 -5.72 -0.3 2.37e-8 Menopause (age at onset); LUSC cis rs34779708 0.931 rs67976880 chr10:35372261 G/C cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6598955 0.671 rs75517917 chr1:26612926 G/T cg00852783 chr1:26633632 UBXN11 -0.48 -5.73 -0.3 2.25e-8 Obesity-related traits; LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs7605827 0.930 rs7577130 chr2:15527859 G/A cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.59e-17 Educational attainment (years of education); LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg13685833 chr1:53393034 SCP2 0.4 6.0 0.31 5.27e-9 Monocyte count; LUSC cis rs3818285 0.504 rs7100154 chr10:111650150 T/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.56 -0.42 4.31e-16 Superior crus of antihelix expression; LUSC cis rs8032315 0.965 rs35346340 chr15:91427872 G/C cg06330618 chr15:91428456 FES 0.29 5.76 0.3 1.89e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg11861562 chr11:117069780 TAGLN 0.33 6.57 0.34 1.91e-10 Blood protein levels; LUSC cis rs7250872 0.647 rs2304613 chr19:1817943 G/C cg18850929 chr19:1828978 REXO1 0.42 6.23 0.32 1.4e-9 Bipolar disorder; LUSC cis rs72781680 0.821 rs116583405 chr2:24208221 T/C cg08917208 chr2:24149416 ATAD2B 0.6 6.84 0.35 3.68e-11 Lymphocyte counts; LUSC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg16624210 chr5:671434 TPPP 0.49 6.39 0.33 5.59e-10 Obesity-related traits; LUSC cis rs1153858 1.000 rs2467864 chr15:45641098 C/T cg14582100 chr15:45693742 SPATA5L1 -0.56 -10.31 -0.49 8.11e-22 Homoarginine levels; LUSC cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg08923669 chr16:420230 MRPL28 0.46 8.02 0.4 1.81e-14 Bone mineral density (spine);Bone mineral density; LUSC trans rs9329221 0.619 rs591346 chr8:9818065 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.39 -0.42 1.4e-15 Neuroticism; LUSC cis rs11168618 0.904 rs7978948 chr12:48930023 A/G cg24011408 chr12:48396354 COL2A1 0.4 6.42 0.33 4.67e-10 Adiponectin levels; LUSC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg18479299 chr3:125709523 NA -0.51 -5.87 -0.31 1.05e-8 Blood pressure (smoking interaction); LUSC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg20891283 chr12:69753455 YEATS4 0.8 13.81 0.6 1.29e-34 Blood protein levels; LUSC trans rs6952808 0.823 rs58222895 chr7:1885064 G/A cg24247370 chr13:99142703 STK24 -0.35 -6.2 -0.32 1.63e-9 Bipolar disorder and schizophrenia; LUSC cis rs1153858 1.000 rs1145081 chr15:45679667 C/G cg26924012 chr15:45694286 SPATA5L1 1.12 20.32 0.74 2.51e-60 Homoarginine levels; LUSC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7123876 0.587 rs61895588 chr11:72360986 A/G cg03713592 chr11:72463424 ARAP1 0.69 7.18 0.37 4.5e-12 Body mass index; LUSC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg05729581 chr11:3078854 CARS -0.54 -8.06 -0.4 1.36e-14 Longevity; LUSC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg05855489 chr10:104503620 C10orf26 0.58 9.32 0.45 1.66e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg13010199 chr12:38710504 ALG10B 0.57 8.64 0.43 2.29e-16 Bladder cancer; LUSC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg22875332 chr1:76189707 ACADM 0.79 11.78 0.54 5.12e-27 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6500395 1.000 rs3743779 chr16:48574040 T/G cg04672837 chr16:48644449 N4BP1 0.46 6.82 0.35 4.17e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs734999 0.545 rs12730932 chr1:2559589 T/G cg18854424 chr1:2615690 NA -0.5 -10.0 -0.48 8.88e-21 Ulcerative colitis; LUSC cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg06784218 chr1:46089804 CCDC17 0.54 10.59 0.5 8.43e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7615952 0.599 rs16834938 chr3:125706046 C/T cg07211511 chr3:129823064 LOC729375 -0.81 -10.67 -0.5 4.41e-23 Blood pressure (smoking interaction); LUSC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg25427524 chr10:38739819 LOC399744 -0.69 -12.57 -0.57 6.41e-30 Extrinsic epigenetic age acceleration; LUSC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg08999081 chr20:33150536 PIGU 0.37 6.74 0.35 6.97e-11 Height; LUSC cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.58 7.42 0.38 1e-12 Multiple sclerosis; LUSC cis rs9902453 0.935 rs9911794 chr17:28349466 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC cis rs4631830 0.720 rs898343 chr10:51505403 A/G cg16070123 chr10:51489643 NA 0.55 9.14 0.45 6.23e-18 Prostate-specific antigen levels; LUSC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg22862634 chr11:62369728 EML3;MTA2 0.59 9.19 0.45 4.35e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7937682 0.924 rs7938360 chr11:111539875 A/G cg22437258 chr11:111473054 SIK2 0.51 6.99 0.36 1.53e-11 Primary sclerosing cholangitis; LUSC cis rs3768617 0.510 rs35968946 chr1:183114871 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.45e-23 Fuchs's corneal dystrophy; LUSC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg25767906 chr1:53392781 SCP2 0.38 6.45 0.33 3.96e-10 Monocyte count; LUSC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg22875332 chr1:76189707 ACADM 0.77 10.32 0.49 7.56e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg26769984 chr7:1090371 C7orf50 -0.73 -10.2 -0.49 1.98e-21 Bronchopulmonary dysplasia; LUSC cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC cis rs8038465 0.516 rs8037836 chr15:73859855 G/A cg15420318 chr15:73925796 NPTN 0.64 11.41 0.53 1.07e-25 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7681440 0.904 rs28734152 chr4:90767359 C/T cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg01879757 chr17:41196368 BRCA1 -0.52 -8.46 -0.42 8.48e-16 Menopause (age at onset); LUSC cis rs8114671 0.562 rs1801310 chr20:33517014 A/G cg07148914 chr20:33460835 GGT7 0.56 8.53 0.42 5.09e-16 Height; LUSC cis rs12893668 0.703 rs34186780 chr14:104027595 T/G cg04998671 chr14:104000505 TRMT61A -0.48 -6.8 -0.35 4.86e-11 Reticulocyte count; LUSC cis rs7267979 0.789 rs9927 chr20:25277244 A/G cg08601574 chr20:25228251 PYGB 0.39 6.12 0.32 2.59e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.68e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg15445000 chr17:37608096 MED1 0.38 6.5 0.34 2.95e-10 Glomerular filtration rate (creatinine); LUSC cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg23791538 chr6:167370224 RNASET2 -0.36 -5.71 -0.3 2.52e-8 Crohn's disease; LUSC cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg08085267 chr17:45401833 C17orf57 0.43 6.52 0.34 2.52e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4947962 0.585 rs10245472 chr7:55147478 G/A cg23757825 chr7:55092271 EGFR -0.46 -5.78 -0.3 1.7e-8 Subjective response to lithium treatment; LUSC cis rs62400317 0.723 rs755 chr6:44795790 C/T cg20913747 chr6:44695427 NA -0.47 -7.27 -0.37 2.55e-12 Total body bone mineral density; LUSC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg08280861 chr8:58055591 NA 0.53 6.27 0.32 1.1e-9 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.45 0.85 7.39e-95 Chronic sinus infection; LUSC cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg25208724 chr1:156163844 SLC25A44 1.08 25.59 0.81 9.83e-81 Testicular germ cell tumor; LUSC cis rs1728785 1.000 rs12918865 chr16:68566546 G/A cg02508848 chr16:68573721 ZFP90 -0.42 -5.72 -0.3 2.31e-8 Ulcerative colitis; LUSC cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg05347473 chr6:146136440 FBXO30 0.48 7.89 0.4 4.3e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.74 10.15 0.49 2.9e-21 Age-related macular degeneration (geographic atrophy); LUSC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.66 11.43 0.53 9.07e-26 Menarche (age at onset); LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.24e-12 Platelet count; LUSC trans rs11098499 0.955 rs1551 chr4:120158500 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.16 0.32 2.03e-9 Corneal astigmatism; LUSC trans rs11098499 0.909 rs28555550 chr4:120211040 C/G cg25214090 chr10:38739885 LOC399744 0.46 6.71 0.34 8.56e-11 Corneal astigmatism; LUSC cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg05347473 chr6:146136440 FBXO30 0.46 7.91 0.4 3.77e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs1994135 0.669 rs11052747 chr12:33697913 C/G cg26384229 chr12:38710491 ALG10B 0.63 8.87 0.44 4.57e-17 Resting heart rate; LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.88 0.63 8.88e-39 Platelet count; LUSC trans rs17683430 0.702 rs117303909 chr22:32377614 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs35110281 0.748 rs2838324 chr21:44999820 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 11.07 0.52 1.8e-24 Mean corpuscular volume; LUSC cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.24e-15 Chronic sinus infection; LUSC cis rs35146811 0.589 rs1727142 chr7:99816179 T/C cg13334819 chr7:99746414 C7orf59 0.51 6.61 0.34 1.53e-10 Coronary artery disease; LUSC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg27535305 chr1:53392650 SCP2 0.33 5.97 0.31 6e-9 Monocyte count; LUSC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg00933542 chr6:150070202 PCMT1 0.33 6.7 0.34 8.84e-11 Lung cancer; LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg14159672 chr1:205819179 PM20D1 0.85 15.29 0.64 2.22e-40 Menarche (age at onset); LUSC trans rs13314892 1.000 rs13314892 chr3:69795052 A/G cg27026831 chr7:72971748 BCL7B 0.46 5.97 0.31 6.23e-9 QRS complex (12-leadsum); LUSC trans rs9630182 0.599 rs11600996 chr11:13396166 T/C cg00234616 chr2:74740572 TLX2 0.3 5.98 0.31 5.71e-9 Bone mineral density; LUSC cis rs7617480 0.558 rs12715430 chr3:48942855 A/C cg07636037 chr3:49044803 WDR6 0.88 11.75 0.54 6.73e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs4499344 0.921 rs752718 chr19:33086262 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.6 -7.86 -0.4 5.19e-14 Mean platelet volume; LUSC cis rs2288073 0.965 rs10199334 chr2:24392618 T/C cg06627628 chr2:24431161 ITSN2 -0.74 -9.98 -0.48 1.08e-20 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs4925386 0.559 rs2427291 chr20:60921324 G/A cg22601191 chr20:60968625 CABLES2 0.55 7.18 0.37 4.51e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs8072100 0.777 rs9914653 chr17:45537395 T/C cg03886242 chr7:26192032 NFE2L3 -0.37 -6.14 -0.32 2.4e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9311676 0.656 rs55783924 chr3:58403610 C/T cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg04362960 chr10:104952993 NT5C2 0.6 9.21 0.45 3.82e-18 Arsenic metabolism; LUSC cis rs3764563 1.000 rs2031061 chr19:15721961 T/C cg20725493 chr19:15740067 CYP4F8 -0.71 -6.97 -0.36 1.75e-11 Inflammatory biomarkers; LUSC cis rs66887589 0.967 rs1155577 chr4:120449810 C/T cg09307838 chr4:120376055 NA -0.48 -7.25 -0.37 2.84e-12 Diastolic blood pressure; LUSC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.43 -7.14 -0.36 5.85e-12 Alzheimer's disease (late onset); LUSC cis rs7618501 1.000 rs7648987 chr3:49868455 A/G cg24110177 chr3:50126178 RBM5 -0.41 -6.6 -0.34 1.6e-10 Intelligence (multi-trait analysis); LUSC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg10560079 chr2:191398806 TMEM194B -0.45 -7.5 -0.38 5.65e-13 Pulse pressure; LUSC cis rs9527 0.590 rs1046411 chr10:104837816 G/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.4 -0.33 5.4e-10 Arsenic metabolism; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg10150615 chr22:24372951 LOC391322 -0.36 -6.17 -0.32 1.97e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7511006 1.000 rs7511006 chr22:50676259 T/C cg07895657 chr22:50616420 PANX2 -0.35 -5.9 -0.31 8.75e-9 Obesity-related traits; LUSC cis rs2455601 0.608 rs16906256 chr11:8887097 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -7.79 -0.39 8.69e-14 Schizophrenia; LUSC cis rs2439831 0.867 rs16957630 chr15:43642780 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg18305652 chr10:134549665 INPP5A 0.45 6.54 0.34 2.36e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7582180 0.591 rs62148360 chr2:101006319 C/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.47 -0.42 8.15e-16 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11997175 0.625 rs2882300 chr8:33585323 G/A ch.8.33884649F chr8:33765107 NA 0.4 6.38 0.33 5.78e-10 Body mass index; LUSC trans rs2587949 0.593 rs2629248 chr3:4238859 A/G cg15139668 chr4:4577005 NA -0.41 -6.22 -0.32 1.51e-9 Periodontitis (DPAL); LUSC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.92 0.35 2.25e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg22782873 chr19:19639568 YJEFN3 -0.47 -5.85 -0.3 1.17e-8 Bipolar disorder; LUSC cis rs7681440 0.560 rs2619371 chr4:90736678 A/G cg06632027 chr4:90757378 SNCA -0.36 -5.73 -0.3 2.24e-8 Dementia with Lewy bodies; LUSC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg17971929 chr21:40555470 PSMG1 -0.63 -10.28 -0.49 9.88e-22 Cognitive function; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg15112475 chr7:1198522 ZFAND2A -0.34 -7.07 -0.36 9.21e-12 Longevity;Endometriosis; LUSC cis rs2439831 0.681 rs484846 chr15:43600803 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.21 0.52 5.56e-25 Lung cancer in ever smokers; LUSC cis rs11252926 0.550 rs10795122 chr10:466830 C/T cg18196295 chr10:418757 DIP2C 0.48 7.49 0.38 6.3e-13 Psychosis in Alzheimer's disease; LUSC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg22508957 chr16:3507546 NAT15 0.68 11.11 0.52 1.28e-24 Tuberculosis; LUSC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg08508325 chr11:3079039 CARS -0.4 -9.04 -0.44 1.27e-17 Longevity; LUSC cis rs4727027 0.704 rs13221837 chr7:148903597 C/T cg23158103 chr7:148848205 ZNF398 -0.49 -8.22 -0.41 4.69e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2721195 0.549 rs2620666 chr8:145703413 T/C cg15857475 chr8:145742913 RECQL4;LRRC14 0.83 14.86 0.63 1.11e-38 Age at first birth; LUSC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.78 0.39 9.12e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs950027 0.620 rs1153860 chr15:45636584 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.47 -0.42 7.81e-16 Response to fenofibrate (adiponectin levels); LUSC trans rs1994135 0.654 rs1447872 chr12:33718343 C/A cg26384229 chr12:38710491 ALG10B 0.72 10.1 0.48 4.28e-21 Resting heart rate; LUSC cis rs9403521 0.898 rs12198291 chr6:143975600 G/A cg18240653 chr6:144019428 PHACTR2 -0.5 -6.07 -0.32 3.51e-9 Obesity-related traits; LUSC cis rs7771547 0.507 rs6457918 chr6:36414308 A/T cg07856975 chr6:36356162 ETV7 -0.35 -6.14 -0.32 2.35e-9 Platelet distribution width; LUSC cis rs7762018 0.660 rs78181018 chr6:170096652 A/C cg19338460 chr6:170058176 WDR27 -1.01 -8.52 -0.42 5.37e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11890956 chr21:40555474 PSMG1 1.02 19.34 0.73 1.88e-56 Cognitive function; LUSC cis rs3806933 0.522 rs12522383 chr5:110455266 C/T cg04022379 chr5:110408740 TSLP 0.61 9.3 0.45 1.89e-18 Eosinophilic esophagitis; LUSC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg01557791 chr16:72042693 DHODH -0.54 -7.88 -0.4 4.73e-14 Fibrinogen levels; LUSC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg05754148 chr16:3507555 NAT15 0.55 8.27 0.41 3.14e-15 Tuberculosis; LUSC cis rs2625529 0.689 rs8178 chr15:72114747 G/A cg16672083 chr15:72433130 SENP8 -0.47 -7.61 -0.38 2.79e-13 Red blood cell count; LUSC cis rs11209185 0.527 rs11209186 chr1:68434340 A/G cg22082780 chr1:68452167 NA -0.44 -7.16 -0.36 5.29e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs713587 0.967 rs6749422 chr2:25150011 C/G cg15423357 chr2:25149977 NA 0.46 9.29 0.45 2.04e-18 Body mass index in non-asthmatics; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg03233332 chr7:66118400 NA -0.42 -5.96 -0.31 6.28e-9 Aortic root size; LUSC cis rs6952809 0.532 rs6461361 chr7:2432167 A/G cg06995285 chr7:2418615 EIF3B 0.38 5.75 0.3 2e-8 Multiple sclerosis; LUSC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs12586317 0.620 rs12588810 chr14:35554484 C/T cg05294307 chr14:35346193 BAZ1A -0.57 -6.73 -0.35 7.5e-11 Psoriasis; LUSC trans rs11098499 1.000 rs28419773 chr4:120211061 T/C cg25214090 chr10:38739885 LOC399744 0.46 6.71 0.34 8.56e-11 Corneal astigmatism; LUSC cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg02475777 chr4:1388615 CRIPAK 0.4 6.07 0.32 3.53e-9 Obesity-related traits; LUSC cis rs9467773 0.506 rs9393709 chr6:26365147 C/T cg09904177 chr6:26538194 HMGN4 -0.48 -7.64 -0.39 2.29e-13 Intelligence (multi-trait analysis); LUSC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg04727924 chr7:799746 HEATR2 -0.59 -6.27 -0.32 1.09e-9 Cerebrospinal P-tau181p levels; LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg25072359 chr17:41440525 NA 0.65 9.22 0.45 3.32e-18 Menopause (age at onset); LUSC cis rs72781680 1.000 rs11553491 chr2:24225901 G/C cg20701182 chr2:24300061 SF3B14 0.6 6.32 0.33 8.22e-10 Lymphocyte counts; LUSC cis rs8060686 0.545 rs17688076 chr16:68286427 C/A cg09835421 chr16:68378352 PRMT7 -0.67 -7.03 -0.36 1.17e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg02951883 chr7:2050386 MAD1L1 0.59 10.76 0.51 2.2e-23 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg11764359 chr7:65958608 NA 0.7 10.9 0.51 7.07e-24 Aortic root size; LUSC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg13319975 chr6:146136371 FBXO30 0.72 11.07 0.52 1.73e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg01097406 chr16:89675127 NA 0.31 6.31 0.33 8.81e-10 Vitiligo; LUSC cis rs694739 0.628 rs475032 chr11:64140737 G/C cg23796481 chr11:64053134 BAD;GPR137 -0.5 -7.89 -0.4 4.4e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7605827 0.930 rs12692268 chr2:15595519 A/G cg19274914 chr2:15703543 NA 0.46 8.76 0.43 1e-16 Educational attainment (years of education); LUSC cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg09184832 chr6:79620586 NA 0.44 7.06 0.36 9.41e-12 Intelligence (multi-trait analysis); LUSC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg11752832 chr7:134001865 SLC35B4 0.55 8.66 0.43 2.09e-16 Mean platelet volume; LUSC cis rs1797081 0.561 rs2603795 chr10:16860256 A/G cg23933602 chr10:16859644 RSU1 0.61 9.8 0.47 4.39e-20 Platelet distribution width; LUSC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.15 17.41 0.69 9.13e-49 Age-related macular degeneration (geographic atrophy); LUSC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg04362960 chr10:104952993 NT5C2 0.5 6.29 0.33 9.94e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs950776 0.518 rs4886571 chr15:78833758 G/A cg22563815 chr15:78856949 CHRNA5 -0.26 -6.2 -0.32 1.65e-9 Sudden cardiac arrest; LUSC trans rs6445975 0.578 rs6772652 chr3:58406693 A/G cg18950693 chr14:70346909 SMOC1 -0.39 -5.96 -0.31 6.27e-9 Systemic lupus erythematosus; LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.7 0.3 2.64e-8 Menopause (age at onset); LUSC cis rs977987 0.806 rs2865531 chr16:75390316 T/A cg04384234 chr16:75411784 CFDP1 -0.4 -6.6 -0.34 1.64e-10 Dupuytren's disease; LUSC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg14668632 chr7:2872130 GNA12 -0.42 -6.53 -0.34 2.47e-10 Height; LUSC cis rs7937682 0.889 rs2850247 chr11:111637202 C/A cg19812747 chr11:111475976 SIK2 0.49 6.93 0.35 2.22e-11 Primary sclerosing cholangitis; LUSC cis rs8099014 0.814 rs4245272 chr18:56115145 T/A cg12907477 chr18:56117327 MIR122 0.45 7.05 0.36 1.01e-11 Platelet count; LUSC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg03804128 chr16:635623 NA 0.31 6.06 0.31 3.74e-9 Height; LUSC cis rs2115630 0.967 rs11073702 chr15:85310071 G/A cg11189052 chr15:85197271 WDR73 -0.46 -6.66 -0.34 1.16e-10 P wave terminal force; LUSC cis rs12540874 0.794 rs1470750 chr7:50576648 C/G cg18232548 chr7:50535776 DDC -0.52 -7.2 -0.37 4.03e-12 Systemic sclerosis; LUSC cis rs1595825 0.945 rs7426250 chr2:198837358 G/A cg10547527 chr2:198650123 BOLL -0.5 -5.85 -0.3 1.16e-8 Ulcerative colitis; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.51 7.82 0.39 7.08e-14 Bipolar disorder; LUSC cis rs7605827 0.964 rs10929367 chr2:15564718 T/C cg19274914 chr2:15703543 NA 0.49 9.41 0.46 8.59e-19 Educational attainment (years of education); LUSC cis rs9650315 0.929 rs7815788 chr8:57179020 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC cis rs7615316 0.934 rs6780250 chr3:142179497 T/C cg16271453 chr3:142027066 XRN1 -0.39 -6.67 -0.34 1.06e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7177699 0.557 rs7403728 chr15:79112016 T/G cg00540400 chr15:79124168 NA -0.48 -8.43 -0.42 1.04e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.19e-30 Aortic root size; LUSC cis rs977987 0.806 rs11862684 chr16:75461746 T/G cg04384234 chr16:75411784 CFDP1 -0.43 -7.01 -0.36 1.35e-11 Dupuytren's disease; LUSC cis rs7100689 0.556 rs6585971 chr10:82145057 G/C cg00277334 chr10:82204260 NA -0.51 -7.34 -0.37 1.64e-12 Post bronchodilator FEV1; LUSC cis rs7572644 0.699 rs1458396 chr2:28136351 A/G cg27432699 chr2:27873401 GPN1 -0.52 -6.95 -0.36 1.91e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg25036284 chr2:26402008 FAM59B -0.74 -10.11 -0.48 3.89e-21 Gut microbiome composition (summer); LUSC cis rs140410685 1 rs140410685 chr1:66118329 GCCT/G cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.36 0.33 6.62e-10 Age at voice drop; LUSC cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg21535247 chr6:8435926 SLC35B3 0.6 9.27 0.45 2.37e-18 Motion sickness; LUSC cis rs1372520 0.684 rs2619356 chr4:90750844 C/T cg01966878 chr4:90757139 SNCA -0.41 -5.89 -0.31 9.29e-9 Neuroticism; LUSC cis rs1395 0.710 rs2083363 chr2:27475318 G/C cg23587288 chr2:27483067 SLC30A3 -0.29 -5.7 -0.3 2.61e-8 Blood metabolite levels; LUSC cis rs72901758 0.768 rs72901762 chr17:76244926 A/G cg26068271 chr17:76253126 NA 0.58 10.03 0.48 7.13e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs3540 0.554 rs12900987 chr15:91071776 T/C cg22089800 chr15:90895588 ZNF774 -0.63 -9.53 -0.46 3.26e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg26354017 chr1:205819088 PM20D1 0.84 14.92 0.63 6.4e-39 Menarche (age at onset); LUSC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg12560992 chr17:57184187 TRIM37 0.64 10.91 0.51 6.55e-24 Intelligence (multi-trait analysis); LUSC cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg05535760 chr7:792225 HEATR2 0.79 9.53 0.46 3.23e-19 Cerebrospinal P-tau181p levels; LUSC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.91 0.31 8.61e-9 Menopause (age at onset); LUSC cis rs146009840 1 rs146009840 chr15:78906177 A/T cg06917634 chr15:78832804 PSMA4 -0.43 -5.75 -0.3 2e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs11098499 0.743 rs10003567 chr4:120241674 C/T cg24375607 chr4:120327624 NA 0.76 12.23 0.56 1.14e-28 Corneal astigmatism; LUSC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg04871131 chr7:94954202 PON1 -0.38 -6.06 -0.31 3.62e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg24692254 chr21:30365293 RNF160 -0.81 -15.08 -0.64 1.53e-39 Dental caries; LUSC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg07414643 chr4:187882934 NA 0.57 10.8 0.51 1.61e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs7980687 0.628 rs2851443 chr12:123694250 C/T cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.84 -0.35 3.89e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs4911259 0.552 rs6058926 chr20:31465450 T/C cg13636640 chr20:31349939 DNMT3B -0.81 -15.5 -0.65 3.33e-41 Inflammatory bowel disease; LUSC cis rs6733011 0.559 rs6711022 chr2:99449536 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.38 -0.33 5.81e-10 Bipolar disorder; LUSC cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg04586622 chr2:25135609 ADCY3 0.43 9.09 0.45 9.3e-18 Body mass index; LUSC cis rs10504229 0.516 rs11776524 chr8:57983246 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -6.22 -0.32 1.48e-9 Developmental language disorder (linguistic errors); LUSC cis rs240764 0.658 rs7740783 chr6:101263516 C/T cg09795085 chr6:101329169 ASCC3 0.46 6.64 0.34 1.29e-10 Neuroticism; LUSC cis rs11039100 1.000 rs12362696 chr11:5828034 G/A cg05234568 chr11:5960015 NA -0.51 -5.73 -0.3 2.27e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12681287 0.752 rs10092651 chr8:87247678 A/C cg27223183 chr8:87520930 FAM82B -0.46 -5.75 -0.3 2.06e-8 Caudate activity during reward; LUSC cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg23711669 chr6:146136114 FBXO30 -0.89 -16.79 -0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs4654899 0.714 rs12123093 chr1:21114416 C/T cg01072550 chr1:21505969 NA -0.41 -6.02 -0.31 4.49e-9 Superior frontal gyrus grey matter volume; LUSC cis rs7267979 0.866 rs6138609 chr20:25570985 T/A cg08601574 chr20:25228251 PYGB 0.39 5.94 0.31 7.13e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg00071950 chr4:10020882 SLC2A9 -0.52 -8.8 -0.43 7.69e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3806843 1.000 rs10057161 chr5:140156831 C/T cg19875535 chr5:140030758 IK 0.5 8.21 0.41 4.85e-15 Depressive symptoms (multi-trait analysis); LUSC trans rs8073060 0.586 rs8064895 chr17:34001121 T/C cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs3125734 0.572 rs7896627 chr10:64046354 T/G cg19640130 chr10:64028056 RTKN2 -0.4 -6.92 -0.35 2.37e-11 Rheumatoid arthritis; LUSC cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg23788917 chr6:8435910 SLC35B3 0.5 7.51 0.38 5.59e-13 Motion sickness; LUSC cis rs1670533 1.000 rs13134921 chr4:1054177 A/G cg16405210 chr4:1374714 KIAA1530 -0.46 -5.64 -0.3 3.56e-8 Recombination rate (females); LUSC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 7.12 0.36 6.47e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg02569458 chr12:86230093 RASSF9 0.58 9.9 0.48 1.96e-20 Major depressive disorder; LUSC cis rs189218934 1 rs189218934 chr15:78903987 T/C cg24631222 chr15:78858424 CHRNA5 -0.69 -9.46 -0.46 5.59e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11098499 0.863 rs3736115 chr4:120488703 A/G cg24375607 chr4:120327624 NA -0.73 -10.94 -0.51 4.98e-24 Corneal astigmatism; LUSC cis rs6469656 1.000 rs10505282 chr8:117676559 T/C cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs793571 0.518 rs12906705 chr15:58955036 C/T cg05156742 chr15:59063176 FAM63B 0.59 6.11 0.32 2.75e-9 Schizophrenia; LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg00166722 chr3:10149974 C3orf24 0.63 8.3 0.41 2.6e-15 Alzheimer's disease; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg10729496 chr3:10149963 C3orf24 0.51 7.06 0.36 9.87e-12 Alzheimer's disease; LUSC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg17971929 chr21:40555470 PSMG1 0.78 13.76 0.6 1.94e-34 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16438291 chr17:1945154 OVCA2;DPH1 -0.42 -6.25 -0.32 1.23e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28735056 1.000 rs28865701 chr18:77620911 A/G cg20368463 chr18:77673604 PQLC1 -0.53 -7.7 -0.39 1.56e-13 Schizophrenia; LUSC cis rs59104589 0.583 rs12624195 chr2:242254734 G/C cg14842376 chr2:242211374 HDLBP 0.59 6.56 0.34 2.05e-10 Fibrinogen levels; LUSC trans rs9324380 0.735 rs4322261 chr1:98405856 G/A cg13344961 chr6:165341241 NA 0.58 6.01 0.31 4.97e-9 Intelligence (multi-trait analysis); LUSC cis rs2979489 0.891 rs2979508 chr8:30388444 C/T cg26383811 chr8:30366931 RBPMS -0.51 -8.18 -0.41 6e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs317689 0.718 rs315122 chr12:69771073 G/T cg11871910 chr12:69753446 YEATS4 0.6 8.04 0.4 1.6e-14 Response to diuretic therapy; LUSC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg10909506 chr17:38081995 ORMDL3 0.33 5.94 0.31 6.99e-9 Self-reported allergy; LUSC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs208520 0.690 rs207102 chr6:66795671 G/A cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs4792901 0.722 rs12601849 chr17:41546288 G/T cg22562494 chr17:41607896 ETV4 -0.33 -6.31 -0.33 8.79e-10 Dupuytren's disease; LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg11645453 chr3:52864694 ITIH4 0.35 7.93 0.4 3.28e-14 Bipolar disorder; LUSC cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -8.58 -0.43 3.55e-16 Chronic sinus infection; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg06873352 chr17:61820015 STRADA 0.72 12.96 0.58 2.1e-31 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg25072359 chr17:41440525 NA 0.65 9.22 0.45 3.32e-18 Menopause (age at onset); LUSC cis rs1865721 1.000 rs8091890 chr18:73197242 T/C cg26385618 chr18:73139727 C18orf62 -0.47 -7.9 -0.4 3.94e-14 Intelligence; LUSC cis rs983392 0.805 rs2081545 chr11:59958380 C/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.78 -0.3 1.74e-8 Alzheimer's disease (late onset); LUSC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg16339924 chr4:17578868 LAP3 0.56 8.53 0.42 5.17e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs17767294 0.708 rs72848753 chr6:27878269 C/G cg19566879 chr6:16334128 ATXN1 0.66 5.98 0.31 5.71e-9 Parkinson's disease; LUSC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg26924012 chr15:45694286 SPATA5L1 1.12 20.85 0.75 2.06e-62 Homoarginine levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04517374 chr20:60981909 CABLES2 0.43 5.94 0.31 7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg02423579 chr7:2872169 GNA12 -0.44 -6.22 -0.32 1.52e-9 Height; LUSC trans rs11723530 0.538 rs4692759 chr4:170806538 G/A cg14385325 chr17:74564821 ST6GALNAC2 -0.31 -6.01 -0.31 4.8e-9 Myopia (pathological); LUSC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg00750074 chr16:89608354 SPG7 -0.52 -9.6 -0.47 1.95e-19 Multiple myeloma (IgH translocation); LUSC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.62 13.21 0.59 2.51e-32 Monocyte percentage of white cells; LUSC cis rs55665837 1.000 rs12792120 chr11:14469443 G/T cg05501817 chr11:14380813 RRAS2 -0.4 -6.5 -0.34 2.85e-10 Vitamin D levels; LUSC cis rs7804356 1.000 rs10248500 chr7:26863294 A/C cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs7605827 0.930 rs1528622 chr2:15557535 A/T cg19274914 chr2:15703543 NA 0.45 8.56 0.42 4.19e-16 Educational attainment (years of education); LUSC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg19920283 chr7:105172520 RINT1 0.59 6.02 0.31 4.72e-9 Bipolar disorder (body mass index interaction); LUSC cis rs11190604 1.000 rs1800662 chr10:102289078 C/A cg07080220 chr10:102295463 HIF1AN 0.7 9.4 0.46 8.73e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs8114671 0.570 rs3761144 chr20:33544075 C/G cg07148914 chr20:33460835 GGT7 0.49 7.35 0.37 1.55e-12 Height; LUSC cis rs11190604 1.000 rs11190587 chr10:102266638 C/T cg16342193 chr10:102329863 NA -0.36 -6.2 -0.32 1.64e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9858542 0.953 rs11715915 chr3:49455330 A/G cg03060546 chr3:49711283 APEH 0.67 9.14 0.45 6.17e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs227833 1.000 rs227833 chr6:44681840 G/C cg20913747 chr6:44695427 NA 0.37 5.72 0.3 2.36e-8 Monobrow; LUSC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg02549819 chr16:58548995 SETD6 0.96 9.03 0.44 1.35e-17 Schizophrenia; LUSC cis rs2742417 0.935 rs2742442 chr3:45748599 T/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.48e-13 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs8073060 0.586 rs225303 chr17:33922149 A/G cg19694781 chr19:47549865 TMEM160 1.1 17.9 0.7 1.04e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs4332037 0.552 rs11773627 chr7:2002733 A/G cg25206134 chr2:45395956 NA 0.49 5.99 0.31 5.3e-9 Bipolar disorder; LUSC cis rs12594515 1.000 rs11855509 chr15:45995474 C/T cg06207120 chr15:45996521 NA 0.39 5.86 0.31 1.11e-8 Waist circumference;Weight; LUSC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg24675056 chr1:15929824 NA -0.47 -8.33 -0.41 2.15e-15 Systolic blood pressure; LUSC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6554196 0.525 rs3819391 chr4:55526702 A/G cg18836493 chr4:55524333 KIT -0.44 -7.51 -0.38 5.51e-13 Monocyte count; LUSC cis rs4820539 1.000 rs916585 chr22:23469438 G/A cg21100191 chr22:23484243 RTDR1 0.92 16.16 0.66 8.69e-44 Bone mineral density; LUSC cis rs9640161 0.830 rs3757424 chr7:150067679 C/A cg21361702 chr7:150065534 REPIN1 0.58 9.16 0.45 5.54e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs4631830 0.900 rs10763576 chr10:51538813 A/T cg10326726 chr10:51549505 MSMB -0.34 -5.74 -0.3 2.14e-8 Prostate-specific antigen levels; LUSC cis rs7103648 0.735 rs3824869 chr11:47378245 T/C cg20307385 chr11:47447363 PSMC3 -0.89 -15.08 -0.64 1.48e-39 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs8077577 0.895 rs16960996 chr17:18110559 A/G cg16794390 chr17:18148240 FLII 0.41 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs5771069 0.896 rs137862 chr22:50446550 C/A cg27068297 chr22:50451975 IL17REL 0.29 5.84 0.3 1.21e-8 Ulcerative colitis; LUSC cis rs2797160 0.905 rs1418641 chr6:125999854 C/T cg05901451 chr6:126070800 HEY2 -0.58 -8.7 -0.43 1.5e-16 Endometrial cancer; LUSC cis rs9811920 0.965 rs10222474 chr3:99862551 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 6.8 0.35 4.75e-11 Axial length; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10981275 chr2:3381760 TSSC1 0.43 6.9 0.35 2.58e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg24642439 chr20:33292090 TP53INP2 0.49 7.23 0.37 3.21e-12 Glomerular filtration rate (creatinine); LUSC cis rs8141529 0.764 rs5752809 chr22:29225500 G/A cg02153584 chr22:29168773 CCDC117 0.66 10.6 0.5 8e-23 Lymphocyte counts; LUSC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg05347473 chr6:146136440 FBXO30 0.53 8.95 0.44 2.59e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg16132339 chr22:24313637 DDTL;DDT -0.39 -6.25 -0.32 1.29e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg12560992 chr17:57184187 TRIM37 -0.84 -15.49 -0.65 3.54e-41 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg05084668 chr3:125655381 ALG1L -0.5 -7.08 -0.36 8.76e-12 Blood pressure (smoking interaction); LUSC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.44 -0.42 9.51e-16 Neuroticism; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03095379 chr16:31106146 VKORC1 0.4 5.98 0.31 5.68e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg21132104 chr15:45694354 SPATA5L1 0.57 8.13 0.41 8.21e-15 Homoarginine levels; LUSC trans rs11098499 0.691 rs9307471 chr4:120261262 G/A cg25214090 chr10:38739885 LOC399744 0.41 6.32 0.33 8.21e-10 Corneal astigmatism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02999463 chr8:37707322 BRF2 0.77 6.01 0.31 4.81e-9 Cognitive performance; LUSC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg12288994 chr5:1860383 NA 0.31 6.98 0.36 1.62e-11 Cardiovascular disease risk factors; LUSC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg21361702 chr7:150065534 REPIN1 -0.49 -6.73 -0.35 7.19e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs9303401 0.659 rs35928756 chr17:56702652 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.61 0.6 7.09e-34 Cognitive test performance; LUSC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg12432903 chr7:1882776 MAD1L1 0.51 6.19 0.32 1.81e-9 Bipolar disorder; LUSC trans rs7567288 0.636 rs34454875 chr2:134460268 G/A cg12381416 chr3:14359266 NA 0.6 6.46 0.33 3.7e-10 Height; LUSC cis rs5769765 0.773 rs138861 chr22:50202276 A/G cg26441486 chr22:50317300 CRELD2 0.48 7.31 0.37 1.97e-12 Schizophrenia; LUSC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg04362960 chr10:104952993 NT5C2 0.52 6.56 0.34 2.07e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6987853 0.563 rs2923408 chr8:42451526 A/G cg09913449 chr8:42400586 C8orf40 0.43 7.27 0.37 2.5e-12 Mean corpuscular hemoglobin concentration; LUSC cis rs1538970 0.781 rs10890330 chr1:45920406 G/A cg05343316 chr1:45956843 TESK2 0.67 8.88 0.44 4.32e-17 Platelet count; LUSC cis rs6543140 0.601 rs7558013 chr2:102992806 G/T cg09003973 chr2:102972529 NA 0.73 8.7 0.43 1.54e-16 Blood protein levels; LUSC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg12365402 chr11:9010492 NRIP3 -0.5 -9.44 -0.46 6.52e-19 Hemoglobin concentration; LUSC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg03036452 chr22:46663545 TTC38 0.58 5.76 0.3 1.88e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg13615516 chr5:77269221 NA 0.39 6.67 0.34 1.07e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs7575217 0.670 rs796061 chr2:101727327 T/C cg23907051 chr2:101730305 TBC1D8 -0.29 -7.7 -0.39 1.52e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs662735 0.515 rs532202 chr11:30839635 C/T cg14844989 chr11:31128820 NA 0.37 5.81 0.3 1.45e-8 Hemoglobin concentration;Hematocrit; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06297571 chr12:132270829 SFRS8 0.41 6.52 0.34 2.59e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs9300255 0.602 rs4372492 chr12:123697357 T/C cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs131777 0.577 rs131748 chr22:51024837 A/G cg00083937 chr22:51039805 MAPK8IP2 -0.5 -8.91 -0.44 3.38e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.78 -0.51 1.94e-23 Alzheimer's disease (late onset); LUSC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg22903471 chr2:27725779 GCKR -0.41 -7.07 -0.36 8.93e-12 Total body bone mineral density; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg12410154 chr3:57261551 APPL1 0.4 6.08 0.32 3.21e-9 Triglycerides; LUSC cis rs453301 0.506 rs476845 chr8:8622877 A/G cg15556689 chr8:8085844 FLJ10661 -0.58 -8.58 -0.42 3.7e-16 Joint mobility (Beighton score); LUSC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg05373962 chr22:49881684 NA -0.44 -10.77 -0.51 2.12e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9329221 0.623 rs7825778 chr8:10261010 C/T cg27411982 chr8:10470053 RP1L1 -0.39 -5.74 -0.3 2.14e-8 Neuroticism; LUSC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg01448562 chr3:133502909 NA -0.71 -11.96 -0.55 1.11e-27 Iron status biomarkers; LUSC cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg00074818 chr8:8560427 CLDN23 0.56 9.55 0.46 2.93e-19 Obesity-related traits; LUSC cis rs35079168 0.735 rs1887309 chr9:137308242 A/G cg14344989 chr9:137329237 RXRA 0.41 6.81 0.35 4.47e-11 Intelligence; LUSC cis rs10875746 0.951 rs10875748 chr12:48526360 A/G cg13454099 chr12:49076203 C12orf41 -0.52 -6.11 -0.32 2.81e-9 Longevity (90 years and older); LUSC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg05623727 chr3:50126028 RBM5 -0.34 -6.54 -0.34 2.26e-10 Body mass index; LUSC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.930 rs1861768 chr2:15625186 C/A cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs11098499 0.866 rs9995136 chr4:120286845 A/G cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs4595586 0.545 rs58154430 chr12:39386649 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.07 0.32 3.39e-9 Morning vs. evening chronotype; LUSC trans rs72674100 1.000 rs28655295 chr4:97990984 T/G cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12618769 1.000 rs72825704 chr2:99239164 T/C cg10123293 chr2:99228465 UNC50 0.41 5.7 0.3 2.57e-8 Bipolar disorder; LUSC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg04398451 chr17:18023971 MYO15A -0.53 -8.94 -0.44 2.79e-17 Total body bone mineral density; LUSC cis rs9399135 0.967 rs12526055 chr6:135325918 C/T cg22676075 chr6:135203613 NA 0.48 7.61 0.38 2.9e-13 Red blood cell count; LUSC cis rs1577917 0.958 rs13213551 chr6:86608701 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.33 -0.33 8.06e-10 Response to antipsychotic treatment; LUSC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg08439880 chr3:133502540 NA -0.39 -7.2 -0.37 4.13e-12 Iron status biomarkers; LUSC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg08917208 chr2:24149416 ATAD2B 0.53 5.97 0.31 6e-9 Lymphocyte counts; LUSC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg24642439 chr20:33292090 TP53INP2 0.72 11.62 0.54 1.86e-26 Coronary artery disease; LUSC cis rs9549260 0.755 rs7333037 chr13:41215256 A/T cg21288729 chr13:41239152 FOXO1 0.63 9.88 0.48 2.33e-20 Red blood cell count; LUSC cis rs2455601 0.608 rs59025804 chr11:8870301 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.43 -7.35 -0.37 1.53e-12 Schizophrenia; LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs56283067 0.578 rs12197755 chr6:45387495 T/G cg18551225 chr6:44695536 NA -0.39 -5.78 -0.3 1.7e-8 Total body bone mineral density; LUSC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg17971929 chr21:40555470 PSMG1 0.74 12.2 0.56 1.43e-28 Cognitive function; LUSC cis rs793571 0.568 rs6494029 chr15:58923206 T/C cg05156742 chr15:59063176 FAM63B 0.57 8.6 0.43 3.18e-16 Schizophrenia; LUSC cis rs8062405 1.000 rs12443881 chr16:28841777 C/T cg05966235 chr16:28915196 ATP2A1 0.34 6.04 0.31 4.01e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs11723530 0.538 rs6848018 chr4:170809088 G/A cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.18 -0.32 1.87e-9 Myopia (pathological); LUSC cis rs79976124 0.719 rs34488909 chr6:66637850 T/C cg07460842 chr6:66804631 NA 0.7 8.69 0.43 1.68e-16 Type 2 diabetes; LUSC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.79 0.63 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6964587 1.000 rs7785971 chr7:91736794 T/A cg01689657 chr7:91764605 CYP51A1 0.31 5.73 0.3 2.22e-8 Breast cancer; LUSC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg23281280 chr6:28129359 ZNF389 0.44 5.8 0.3 1.52e-8 Parkinson's disease; LUSC cis rs2486288 0.656 rs8039354 chr15:45551756 A/G cg14582100 chr15:45693742 SPATA5L1 0.41 7.59 0.38 3.33e-13 Glomerular filtration rate; LUSC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 10.1 0.48 4.09e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg21535247 chr6:8435926 SLC35B3 0.59 9.11 0.45 7.89e-18 Motion sickness; LUSC cis rs17001868 0.527 rs9611324 chr22:40781162 T/C cg07138101 chr22:40742427 ADSL 0.53 6.51 0.34 2.69e-10 Mammographic density (dense area); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg12107626 chr17:39992626 KLHL10;NT5C3L 0.49 6.2 0.32 1.71e-9 Cognitive function;Information processing speed; LUSC cis rs11098499 0.754 rs12509621 chr4:120249660 T/C cg24375607 chr4:120327624 NA 0.75 12.14 0.55 2.34e-28 Corneal astigmatism; LUSC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg19717773 chr7:2847554 GNA12 -0.36 -5.95 -0.31 6.63e-9 Height; LUSC cis rs1371867 0.817 rs1660315 chr8:101332956 G/A cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg20933634 chr6:27740509 NA 0.43 6.16 0.32 2.12e-9 Parkinson's disease; LUSC cis rs7177699 0.557 rs8035093 chr15:79120670 T/C cg15571903 chr15:79123663 NA 0.32 5.91 0.31 8.39e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2692947 0.526 rs4907225 chr2:96576670 C/T cg23100626 chr2:96804247 ASTL 0.3 7.08 0.36 8.71e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs3845702 0.736 rs72960660 chr2:180832482 A/G cg01881094 chr2:180872142 CWC22 1.06 12.67 0.57 2.59e-30 Schizophrenia; LUSC cis rs61931739 0.534 rs11053005 chr12:34091626 A/C cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg24531977 chr5:56204891 C5orf35 -0.64 -9.57 -0.46 2.52e-19 Coronary artery disease; LUSC trans rs11014632 0.509 rs4747531 chr10:25865513 G/A cg07132650 chr16:83659882 CDH13 0.37 5.99 0.31 5.32e-9 Intraocular pressure; LUSC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg18765753 chr7:1198926 ZFAND2A -0.6 -11.6 -0.54 2.32e-26 Longevity;Endometriosis; LUSC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg09021430 chr5:549028 NA -0.57 -8.38 -0.42 1.51e-15 Obesity-related traits; LUSC cis rs908922 0.887 rs6587688 chr1:152529622 C/T cg20991723 chr1:152506922 NA -0.51 -8.74 -0.43 1.16e-16 Hair morphology; LUSC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg11245181 chr6:149772854 ZC3H12D 0.29 6.22 0.32 1.45e-9 Dupuytren's disease; LUSC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg13939156 chr17:80058883 NA 0.34 6.54 0.34 2.35e-10 Life satisfaction; LUSC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Parkinson's disease; LUSC cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -7.62 -0.38 2.62e-13 Bone mineral density; LUSC cis rs13217239 0.646 rs7451149 chr6:27057518 A/G cg09904177 chr6:26538194 HMGN4 -0.47 -7.51 -0.38 5.45e-13 Schizophrenia; LUSC trans rs72674100 1.000 rs28461859 chr4:97988033 T/A cg16405019 chr1:18959625 PAX7 -0.58 -6.33 -0.33 7.76e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9788721 1.000 rs10519203 chr15:78814046 C/T cg06917634 chr15:78832804 PSMA4 0.46 6.36 0.33 6.6e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05871582 chr8:648014 ERICH1 0.42 6.16 0.32 2.07e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05226292 chr8:71520850 TRAM1 -0.51 -6.32 -0.33 8.27e-10 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.522 rs117743143 chr12:38030824 C/T cg26384229 chr12:38710491 ALG10B 0.81 13.56 0.6 1.09e-33 Bladder cancer; LUSC cis rs9443645 0.527 rs4706746 chr6:79674176 G/A cg05283184 chr6:79620031 NA -0.45 -8.59 -0.43 3.35e-16 Intelligence (multi-trait analysis); LUSC cis rs516243 0.703 rs284313 chr1:10736434 A/G cg02903756 chr1:10750680 CASZ1 -0.47 -8.44 -0.42 9.76e-16 Migraine - clinic-based; LUSC cis rs11864453 1.000 rs11864453 chr16:72050480 C/T cg01557791 chr16:72042693 DHODH -0.57 -8.57 -0.42 4e-16 Fibrinogen levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01423147 chr1:89458345 RBMXL1;CCBL2 -0.43 -6.47 -0.33 3.51e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08808811 chr3:184079573 CLCN2 -0.51 -6.51 -0.34 2.73e-10 Bipolar disorder and schizophrenia; LUSC cis rs6669072 0.679 rs1766162 chr1:91313066 C/T cg08895590 chr1:91227319 NA 0.33 7.05 0.36 1.03e-11 Cognitive function; LUSC cis rs12681287 0.752 rs4534114 chr8:87271956 A/G cg27223183 chr8:87520930 FAM82B -0.46 -5.92 -0.31 7.82e-9 Caudate activity during reward; LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg04944784 chr2:26401820 FAM59B 0.79 11.29 0.53 2.95e-25 Gut microbiome composition (summer); LUSC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg17143192 chr8:8559678 CLDN23 0.38 5.92 0.31 7.81e-9 Mood instability; LUSC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg16797656 chr11:68205561 LRP5 -0.39 -7.13 -0.36 6.15e-12 Total body bone mineral density; LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs225245 0.782 rs161183 chr17:33919475 G/C cg19694781 chr19:47549865 TMEM160 -0.41 -6.61 -0.34 1.51e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9807989 0.507 rs6758936 chr2:102991369 A/G cg03938978 chr2:103052716 IL18RAP -0.36 -6.89 -0.35 2.77e-11 Asthma; LUSC cis rs6700896 0.500 rs12025906 chr1:66101384 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.56 6.36 0.33 6.49e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11098499 0.954 rs2306455 chr4:120421969 G/A cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs13315871 0.929 rs2056120 chr3:58309436 A/T cg20936604 chr3:58311152 NA -0.72 -6.98 -0.36 1.63e-11 Cholesterol, total; LUSC cis rs790123 0.692 rs790118 chr3:122380614 C/A cg00926285 chr3:122398533 PARP14 -0.42 -5.97 -0.31 6.04e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs7903847 0.642 rs11817875 chr10:99158414 G/A cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.59e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs607541 0.764 rs629880 chr15:45934810 A/T cg26924012 chr15:45694286 SPATA5L1 0.55 5.86 0.31 1.1e-8 Obesity-related traits; LUSC cis rs1448094 0.842 rs7301280 chr12:86455752 G/T cg00310523 chr12:86230176 RASSF9 -0.35 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs7000551 0.725 rs2249102 chr8:22400193 C/G cg12081754 chr8:22256438 SLC39A14 0.4 5.78 0.3 1.74e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg08213375 chr14:104286397 PPP1R13B -0.52 -10.4 -0.49 3.92e-22 Schizophrenia; LUSC trans rs953492 0.672 rs1766030 chr1:243314577 C/T cg27113374 chr10:38692187 CDC10L -0.4 -5.97 -0.31 6.14e-9 Diastolic blood pressure; LUSC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg10909506 chr17:38081995 ORMDL3 0.32 5.78 0.3 1.7e-8 Self-reported allergy; LUSC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg20302533 chr7:39170763 POU6F2 0.55 8.92 0.44 3.18e-17 IgG glycosylation; LUSC cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.37 0.37 1.31e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05167392 chr10:103874593 LDB1 0.42 6.17 0.32 1.98e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9457247 0.602 rs4710175 chr6:167467800 A/G cg07741184 chr6:167504864 NA 0.51 8.94 0.44 2.77e-17 Crohn's disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08269986 chr1:35735167 ZMYM4 -0.42 -6.14 -0.32 2.33e-9 Hepatitis; LUSC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9300255 0.544 rs1716174 chr12:123660717 T/C cg13010344 chr12:123464640 ARL6IP4 -0.57 -6.79 -0.35 5.23e-11 Neutrophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05482832 chr17:74734106 MIR636;SFRS2;MFSD11 -0.43 -6.39 -0.33 5.54e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg10802521 chr3:52805072 NEK4 -0.56 -8.71 -0.43 1.43e-16 Bipolar disorder; LUSC cis rs7771547 0.519 rs67313027 chr6:36363487 G/C cg07856975 chr6:36356162 ETV7 0.43 6.21 0.32 1.59e-9 Platelet distribution width; LUSC cis rs4474465 1.000 rs11237522 chr11:78209879 A/G cg27205649 chr11:78285834 NARS2 -0.54 -6.23 -0.32 1.41e-9 Alzheimer's disease (survival time); LUSC cis rs501916 0.634 rs3743286 chr15:48065792 A/G cg16110827 chr15:48056943 SEMA6D -0.39 -6.0 -0.31 5.18e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs9788682 1.000 rs7181447 chr15:78814567 A/G cg06917634 chr15:78832804 PSMA4 -0.58 -7.24 -0.37 3.03e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs6690583 0.623 rs893620 chr1:85425821 T/C cg11262906 chr1:85462892 MCOLN2 0.69 6.63 0.34 1.37e-10 Serum sulfate level; LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg27094323 chr7:1216898 NA -0.35 -6.11 -0.32 2.84e-9 Longevity;Endometriosis; LUSC cis rs6840360 0.571 rs55808836 chr4:152554991 C/T cg22705602 chr4:152727874 NA -0.31 -6.17 -0.32 1.98e-9 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg05283184 chr6:79620031 NA 0.56 11.42 0.53 1.03e-25 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs79149102 0.579 rs12591175 chr15:75356073 C/T cg09165964 chr15:75287851 SCAMP5 -0.87 -7.77 -0.39 9.65e-14 Lung cancer; LUSC cis rs4974559 0.739 rs28412861 chr4:1320092 A/G cg02980000 chr4:1222292 CTBP1 0.97 9.1 0.45 8.62e-18 Systolic blood pressure; LUSC cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg13010199 chr12:38710504 ALG10B 0.66 10.22 0.49 1.61e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 15.19 0.64 5.33e-40 Platelet count; LUSC cis rs7267979 0.966 rs7270835 chr20:25435067 C/T cg08601574 chr20:25228251 PYGB 0.43 6.57 0.34 1.94e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg14829155 chr15:31115871 NA 0.6 9.08 0.45 9.48e-18 Huntington's disease progression; LUSC cis rs2806561 0.765 rs1612905 chr1:23510023 G/T cg19743168 chr1:23544995 NA 0.4 7.86 0.39 5.44e-14 Height; LUSC cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg13010199 chr12:38710504 ALG10B 0.65 10.14 0.49 2.97e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.24 -0.37 3.13e-12 Height; LUSC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 14.38 0.62 8.07e-37 Platelet count; LUSC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs4478858 0.735 rs4949389 chr1:31824023 A/G cg00250761 chr1:31883323 NA 0.36 8.4 0.42 1.34e-15 Alcohol dependence; LUSC cis rs7818345 0.967 rs11204039 chr8:19280442 A/C cg11303988 chr8:19266685 CSGALNACT1 0.38 7.19 0.37 4.25e-12 Language performance in older adults (adjusted for episodic memory); LUSC trans rs853679 0.517 rs9357065 chr6:28129580 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs4776059 1.000 rs62023352 chr15:52889448 T/C cg25063058 chr15:52860530 ARPP19 0.46 6.29 0.33 1.01e-9 Schizophrenia; LUSC cis rs1107366 1.000 rs9873704 chr3:125901902 G/C cg20988073 chr3:125900093 ALDH1L1 -0.32 -6.36 -0.33 6.51e-10 Metabolite levels; LUSC cis rs2835872 0.759 rs4816567 chr21:38988155 T/C cg20424643 chr21:39039972 KCNJ6 0.36 5.68 0.3 2.91e-8 Electroencephalographic traits in alcoholism; LUSC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg11663144 chr21:46675770 NA -0.42 -7.3 -0.37 2.18e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8114671 0.804 rs3803936 chr20:33632775 T/C cg07148914 chr20:33460835 GGT7 -0.45 -6.67 -0.34 1.07e-10 Height; LUSC cis rs2072499 0.966 rs1060604 chr1:156184268 T/C cg25208724 chr1:156163844 SLC25A44 1.08 22.41 0.78 1.51e-68 Testicular germ cell tumor; LUSC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg04455712 chr21:45112962 RRP1B 0.46 8.67 0.43 1.94e-16 Mean corpuscular volume; LUSC cis rs9311676 0.632 rs6445978 chr3:58379586 T/A cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs950027 0.620 rs2461700 chr15:45640627 T/C cg14582100 chr15:45693742 SPATA5L1 0.44 8.44 0.42 1.01e-15 Response to fenofibrate (adiponectin levels); LUSC cis rs1005224 1.000 rs1005224 chr14:76173860 A/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.51 -6.72 -0.35 7.75e-11 Large artery stroke; LUSC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg16405210 chr4:1374714 KIAA1530 -0.57 -9.05 -0.44 1.24e-17 Obesity-related traits; LUSC cis rs34172651 0.917 rs8043962 chr16:24781372 A/G cg06028605 chr16:24865363 SLC5A11 0.46 8.1 0.41 1.02e-14 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg16586182 chr3:47516702 SCAP -0.51 -8.04 -0.4 1.62e-14 Colorectal cancer; LUSC cis rs7582180 0.790 rs4851288 chr2:100920451 T/C cg12002119 chr2:101014098 CHST10 0.34 5.74 0.3 2.11e-8 Intelligence (multi-trait analysis); LUSC cis rs7103648 0.966 rs1534576 chr11:47419663 A/C cg20307385 chr11:47447363 PSMC3 -0.99 -19.49 -0.73 4.99e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs1559088 0.803 rs10405770 chr19:33616549 C/T cg03563238 chr19:33554763 RHPN2 -0.37 -5.97 -0.31 6.18e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7089973 0.604 rs7897937 chr10:116591318 A/G cg03647239 chr10:116582469 FAM160B1 0.45 7.27 0.37 2.55e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs16912285 0.688 rs12279442 chr11:24317174 C/G ch.11.24196551F chr11:24239977 NA 0.9 9.64 0.47 1.45e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs208520 0.690 rs207094 chr6:66799009 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.61 -0.69 1.49e-49 Exhaled nitric oxide output; LUSC cis rs11190604 0.767 rs7916904 chr10:102186778 C/G cg07080220 chr10:102295463 HIF1AN 0.59 8.0 0.4 2.03e-14 Palmitoleic acid (16:1n-7) levels; LUSC trans rs1941687 0.797 rs12607190 chr18:31394699 G/A cg27147174 chr7:100797783 AP1S1 -0.44 -6.46 -0.33 3.71e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs11098499 0.863 rs3775845 chr4:120432447 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.61 0.34 1.48e-10 Corneal astigmatism; LUSC trans rs12310956 0.532 rs11608842 chr12:33951121 C/T cg26384229 chr12:38710491 ALG10B 0.65 10.24 0.49 1.37e-21 Morning vs. evening chronotype; LUSC trans rs11088226 0.681 rs2833895 chr21:33929802 G/A cg09050820 chr6:167586206 TCP10L2 0.75 9.74 0.47 6.57e-20 Gastritis; LUSC cis rs1577917 0.958 rs13219504 chr6:86556917 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.77 -0.43 9.17e-17 Response to antipsychotic treatment; LUSC cis rs35883536 0.551 rs6666607 chr1:101032368 A/G cg09408571 chr1:101003634 GPR88 -0.3 -5.71 -0.3 2.46e-8 Monocyte count; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg06873352 chr17:61820015 STRADA 0.7 12.21 0.56 1.32e-28 Prudent dietary pattern; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05981015 chr17:27717136 TAOK1 0.42 5.99 0.31 5.37e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7223966 1.000 rs8067431 chr17:61817048 T/C cg00945038 chr17:61921165 SMARCD2 0.38 5.65 0.3 3.45e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg22601191 chr20:60968625 CABLES2 -0.37 -5.92 -0.31 7.96e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs11864453 0.713 rs9925763 chr16:72142595 C/A cg16558253 chr16:72132732 DHX38 -0.4 -6.16 -0.32 2.06e-9 Fibrinogen levels; LUSC cis rs62103177 0.810 rs62096745 chr18:77619135 A/G cg20368463 chr18:77673604 PQLC1 0.62 5.73 0.3 2.19e-8 Opioid sensitivity; LUSC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg05872129 chr22:39784769 NA -0.59 -10.78 -0.51 1.82e-23 Intelligence (multi-trait analysis); LUSC cis rs9902453 0.765 rs2729436 chr17:28120670 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.67 -0.54 1.26e-26 Coffee consumption (cups per day); LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg08677398 chr8:58056175 NA 0.53 7.05 0.36 1.04e-11 Developmental language disorder (linguistic errors); LUSC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg06697600 chr4:7070879 GRPEL1 -0.42 -7.19 -0.37 4.34e-12 Monocyte percentage of white cells; LUSC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg24733560 chr20:60626293 TAF4 0.41 6.73 0.35 7.47e-11 Body mass index; LUSC trans rs953492 0.701 rs1796846 chr1:243306924 A/G cg01826367 chr1:224180288 NA -0.42 -6.43 -0.33 4.29e-10 Diastolic blood pressure; LUSC cis rs2832077 0.506 rs2832081 chr21:30152992 A/C cg08807101 chr21:30365312 RNF160 0.47 6.37 0.33 6.12e-10 Cognitive test performance; LUSC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21582582 chr3:182698605 DCUN1D1 0.45 8.15 0.41 7.46e-15 Intelligence (multi-trait analysis); LUSC trans rs877282 0.945 rs10904556 chr10:789429 A/G cg22713356 chr15:30763199 NA 1.09 15.49 0.65 3.65e-41 Uric acid levels; LUSC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.37 5.88 0.31 9.88e-9 Total body bone mineral density; LUSC cis rs432925 0.600 rs385862 chr16:344659 A/G cg08823186 chr16:347294 AXIN1 0.34 5.97 0.31 6.06e-9 Morning vs. evening chronotype; LUSC cis rs2996428 0.667 rs113120570 chr1:3770450 G/C cg22529645 chr1:3704559 LRRC47 0.35 6.12 0.32 2.63e-9 Red cell distribution width; LUSC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg03676636 chr4:99064102 C4orf37 0.37 7.91 0.4 3.7e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg02772935 chr3:125709198 NA -0.48 -5.78 -0.3 1.67e-8 Blood pressure (smoking interaction); LUSC cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.17 0.52 7.99e-25 Colorectal cancer; LUSC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg04121214 chr22:50244548 NA -0.34 -5.69 -0.3 2.79e-8 Schizophrenia; LUSC cis rs921665 0.505 rs1037467 chr2:3200948 A/C cg02624386 chr2:3182749 NA -0.58 -6.45 -0.33 3.96e-10 World class endurance athleticism; LUSC cis rs4343996 1.000 rs7794279 chr7:3341806 A/G cg21248987 chr7:3385318 SDK1 0.4 6.83 0.35 4.07e-11 Motion sickness; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg16325326 chr1:53192061 ZYG11B 0.7 11.29 0.53 3.04e-25 Monocyte count; LUSC cis rs11155671 0.530 rs7758020 chr6:150208111 T/C cg13206674 chr6:150067644 NUP43 0.43 6.56 0.34 2.01e-10 Testicular germ cell tumor; LUSC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs72634258 0.945 rs225132 chr1:8095500 A/C cg00042356 chr1:8021962 PARK7 0.63 7.8 0.39 8.15e-14 Inflammatory bowel disease; LUSC cis rs62400317 0.859 rs10948201 chr6:45093494 A/C cg18551225 chr6:44695536 NA 0.42 6.73 0.35 7.45e-11 Total body bone mineral density; LUSC cis rs1124376 1.000 rs12488369 chr3:20154059 G/T cg05072819 chr3:20081367 KAT2B -0.65 -7.56 -0.38 3.83e-13 Bipolar disorder and schizophrenia; LUSC cis rs7804356 0.906 rs10225904 chr7:26869888 G/A cg03456212 chr7:26904342 SKAP2 -0.56 -6.44 -0.33 4.06e-10 Type 1 diabetes; LUSC cis rs9660992 1.000 rs1779410 chr1:205248759 A/G cg21545522 chr1:205238299 TMCC2 0.42 7.94 0.4 3.01e-14 Mean corpuscular volume;Mean platelet volume; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06112727 chr8:22102711 POLR3D;MIR320A -0.43 -6.37 -0.33 6.14e-10 Electrocardiographic conduction measures; LUSC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Melanoma; LUSC trans rs11088226 0.645 rs2833904 chr21:33941089 T/C cg09050820 chr6:167586206 TCP10L2 0.73 9.47 0.46 5.31e-19 Gastritis; LUSC cis rs3812762 0.843 rs10732515 chr11:8801790 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.4 6.97 0.36 1.69e-11 Hypospadias; LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04807856 chr11:73685776 UCP2 0.37 6.25 0.32 1.22e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg27535305 chr1:53392650 SCP2 0.39 7.26 0.37 2.82e-12 Monocyte count; LUSC cis rs826838 1.000 rs9795768 chr12:39012479 T/C cg26384229 chr12:38710491 ALG10B 0.93 17.86 0.7 1.45e-50 Heart rate; LUSC cis rs2921073 0.509 rs2976931 chr8:8257317 C/A cg08975724 chr8:8085496 FLJ10661 0.51 7.78 0.39 9.06e-14 Parkinson's disease; LUSC cis rs11098499 0.754 rs1546503 chr4:120241167 T/C cg09307838 chr4:120376055 NA 0.69 10.16 0.49 2.54e-21 Corneal astigmatism; LUSC cis rs11122272 0.735 rs722302 chr1:231480152 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.07 -0.48 5.45e-21 Hemoglobin concentration; LUSC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.22 -0.32 1.46e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg20456258 chr4:962124 DGKQ 0.33 6.18 0.32 1.89e-9 Sjögren's syndrome; LUSC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg06637938 chr14:75390232 RPS6KL1 0.52 8.36 0.42 1.68e-15 Height; LUSC trans rs6952808 0.723 rs60432611 chr7:2029629 G/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.41 0.33 4.9e-10 Bipolar disorder and schizophrenia; LUSC cis rs7927771 0.524 rs10838774 chr11:47856114 A/G cg20307385 chr11:47447363 PSMC3 0.43 6.32 0.33 8.29e-10 Subjective well-being; LUSC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg17971929 chr21:40555470 PSMG1 -0.63 -10.39 -0.49 4.14e-22 Cognitive function; LUSC cis rs3820928 0.934 rs4675117 chr2:227769794 A/G cg11843606 chr2:227700838 RHBDD1 0.54 7.64 0.39 2.28e-13 Pulmonary function; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg00431813 chr7:1051703 C7orf50 -0.38 -5.97 -0.31 6.1e-9 Longevity;Endometriosis; LUSC cis rs9815354 1.000 rs1717006 chr3:41940448 A/C cg03022575 chr3:42003672 ULK4 0.53 5.96 0.31 6.27e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 5.89 0.31 9.27e-9 Schizophrenia; LUSC cis rs9653442 0.564 rs7601892 chr2:100789490 G/A cg22139774 chr2:100720529 AFF3 -0.41 -7.04 -0.36 1.09e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs1728785 1.000 rs11648314 chr16:68596775 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.85 0.39 5.61e-14 Ulcerative colitis; LUSC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg17366294 chr4:99064904 C4orf37 0.59 10.39 0.49 4.12e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs8078723 0.668 rs3859191 chr17:38128714 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.5 -8.42 -0.42 1.13e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg17366294 chr4:99064904 C4orf37 0.55 9.51 0.46 3.91e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9914988 0.943 rs11652272 chr17:27167973 C/G cg09479241 chr17:27052676 TLCD1 0.46 6.23 0.32 1.44e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg11301795 chr4:187892539 NA -0.83 -16.18 -0.66 6.79e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg09877947 chr5:131593287 PDLIM4 0.59 10.0 0.48 8.91e-21 Acylcarnitine levels; LUSC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg23985595 chr17:80112537 CCDC57 0.31 5.88 0.31 9.8e-9 Life satisfaction; LUSC cis rs8077889 0.917 rs8081646 chr17:41893360 T/C cg26893861 chr17:41843967 DUSP3 0.88 13.77 0.6 1.79e-34 Triglycerides; LUSC cis rs12421382 0.614 rs12799395 chr11:109390862 G/T cg27471124 chr11:109292789 C11orf87 0.37 6.74 0.35 6.83e-11 Schizophrenia; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 14.01 0.61 2.15e-35 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25509121 chr17:61851092 DDX42;CCDC47 0.47 6.49 0.33 3.06e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2708977 0.933 rs2464914 chr2:97179828 A/G cg01950434 chr2:97203154 ARID5A -0.54 -8.05 -0.4 1.46e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg07424592 chr7:64974309 NA -0.64 -5.73 -0.3 2.24e-8 Diabetic kidney disease; LUSC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg18876405 chr7:65276391 NA 0.55 8.81 0.43 6.74e-17 Aortic root size; LUSC cis rs10887741 0.646 rs7903568 chr10:89433931 T/A cg13926569 chr10:89418898 PAPSS2 0.32 6.87 0.35 3.19e-11 Exercise (leisure time); LUSC cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg08997352 chr12:9597637 DDX12 -0.6 -9.5 -0.46 4.24e-19 Breast size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01720705 chr1:231175557 FAM89A -0.43 -5.99 -0.31 5.45e-9 Bipolar disorder and schizophrenia; LUSC cis rs7202877 0.656 rs247427 chr16:75439132 T/C cg04384234 chr16:75411784 CFDP1 0.63 8.18 0.41 5.87e-15 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7582180 0.652 rs11678158 chr2:100932297 T/C cg08017756 chr2:100939284 LONRF2 -0.47 -8.78 -0.43 8.83e-17 Intelligence (multi-trait analysis); LUSC cis rs992157 0.687 rs10206984 chr2:219066980 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.49 7.69 0.39 1.7e-13 Colorectal cancer; LUSC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg09238746 chr17:78121135 EIF4A3 0.97 14.88 0.63 8.88e-39 Yeast infection; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg22437258 chr11:111473054 SIK2 0.52 7.29 0.37 2.29e-12 Primary sclerosing cholangitis; LUSC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg13385521 chr17:29058706 SUZ12P 0.66 6.43 0.33 4.49e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs7615952 0.673 rs35955861 chr3:125626201 T/C cg07211511 chr3:129823064 LOC729375 -1.02 -12.72 -0.57 1.71e-30 Blood pressure (smoking interaction); LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg01238044 chr22:24384105 GSTT1 -0.56 -8.83 -0.43 6.13e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg21724239 chr8:58056113 NA 0.77 7.97 0.4 2.61e-14 Developmental language disorder (linguistic errors); LUSC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs497273 0.534 rs608394 chr12:121194053 C/T cg02419362 chr12:121203948 SPPL3 0.43 7.8 0.39 8.14e-14 Systemic lupus erythematosus; LUSC cis rs6582630 0.538 rs7971292 chr12:38498151 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.67 -0.43 1.92e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg00343986 chr7:65444356 GUSB -0.4 -6.13 -0.32 2.46e-9 Aortic root size; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg03579872 chr1:53393473 SCP2 -0.39 -5.97 -0.31 6.13e-9 Monocyte count; LUSC cis rs4919087 0.962 rs3814164 chr10:98982749 G/A cg25902810 chr10:99078978 FRAT1 0.5 7.1 0.36 7.66e-12 Monocyte count; LUSC cis rs921968 0.541 rs12987171 chr2:219327030 G/C cg02176678 chr2:219576539 TTLL4 0.74 14.33 0.62 1.24e-36 Mean corpuscular hemoglobin concentration; LUSC trans rs9329221 0.935 rs6601450 chr8:10243101 G/T cg06636001 chr8:8085503 FLJ10661 0.48 7.13 0.36 6.42e-12 Neuroticism; LUSC cis rs4604732 0.588 rs4925552 chr1:247631749 C/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.42 6.58 0.34 1.78e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1055129 0.537 rs2467100 chr17:73949038 C/G cg08125733 chr17:73851984 WBP2 0.49 7.0 0.36 1.38e-11 White matter hyperintensity burden; LUSC cis rs9296092 0.517 rs11752179 chr6:33534713 G/T cg13560919 chr6:33536144 NA -0.86 -16.62 -0.67 1.25e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.15 -0.32 2.16e-9 Total body bone mineral density; LUSC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6906287 0.625 rs7453914 chr6:118692981 A/T cg21191810 chr6:118973309 C6orf204 0.38 6.97 0.36 1.66e-11 Electrocardiographic conduction measures; LUSC cis rs11971779 0.680 rs6467843 chr7:139070523 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg04944784 chr2:26401820 FAM59B 0.77 11.36 0.53 1.68e-25 Gut microbiome composition (summer); LUSC trans rs7824557 0.545 rs2572450 chr8:11229638 C/T cg06636001 chr8:8085503 FLJ10661 -0.57 -8.46 -0.42 8.36e-16 Retinal vascular caliber; LUSC cis rs7267979 1.000 rs2259956 chr20:25282433 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9325144 0.560 rs7314632 chr12:38636979 C/T cg13010199 chr12:38710504 ALG10B -0.53 -8.01 -0.4 1.97e-14 Morning vs. evening chronotype; LUSC cis rs6500602 0.963 rs7201012 chr16:4480682 C/G cg08645402 chr16:4508243 NA 0.54 9.09 0.45 8.97e-18 Schizophrenia; LUSC cis rs55675132 0.704 rs57276179 chr1:115606491 A/G cg01522456 chr1:115632236 TSPAN2 -0.45 -5.7 -0.3 2.65e-8 Schizophrenia; LUSC cis rs9486719 0.901 rs760619 chr6:96857431 A/G cg06623918 chr6:96969491 KIAA0776 0.77 9.23 0.45 3.28e-18 Migraine;Coronary artery disease; LUSC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg22029157 chr1:209979665 IRF6 0.78 8.93 0.44 2.98e-17 Cleft lip with or without cleft palate; LUSC cis rs9677476 0.863 rs10181630 chr2:232091757 C/T cg07929768 chr2:232055508 NA 0.35 6.5 0.34 2.88e-10 Food antigen IgG levels; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg00149659 chr3:10157352 C3orf10 0.99 14.46 0.62 3.71e-37 Alzheimer's disease; LUSC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.71 10.6 0.5 7.97e-23 Cognitive test performance; LUSC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.29e-11 Glomerular filtration rate (creatinine); LUSC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg24399712 chr22:39784796 NA -0.63 -10.43 -0.5 3e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs67981189 0.634 rs221900 chr14:71604354 C/T cg15816911 chr14:71606274 NA 0.37 6.61 0.34 1.51e-10 Schizophrenia; LUSC cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.84 -0.54 3.05e-27 Chronic sinus infection; LUSC cis rs1348850 0.914 rs12616443 chr2:178315751 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.13 0.36 6.42e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs11098499 0.909 rs79026312 chr4:120440677 C/A cg25214090 chr10:38739885 LOC399744 0.52 7.54 0.38 4.52e-13 Corneal astigmatism; LUSC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg24642844 chr7:1081250 C7orf50 -0.46 -7.4 -0.38 1.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1163251 0.902 rs514491 chr1:120216743 C/T cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC trans rs11098499 0.955 rs1511015 chr4:120170473 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg07167872 chr1:205819463 PM20D1 0.48 6.88 0.35 3.05e-11 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs62408225 1.000 rs2325291 chr6:90986686 G/A cg06866423 chr6:90926672 BACH2 0.42 5.92 0.31 8.02e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6543140 0.964 rs10169192 chr2:103072211 A/G cg09003973 chr2:102972529 NA 0.54 7.02 0.36 1.25e-11 Blood protein levels; LUSC cis rs2637266 0.783 rs11001866 chr10:78486774 C/T cg18941641 chr10:78392320 NA 0.36 6.61 0.34 1.53e-10 Pulmonary function; LUSC cis rs1385374 0.563 rs12299194 chr12:129264838 A/G cg09035930 chr12:129282057 SLC15A4 -0.61 -6.53 -0.34 2.44e-10 Systemic lupus erythematosus; LUSC cis rs6469656 1.000 rs13262725 chr8:117661566 C/T cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg26924012 chr15:45694286 SPATA5L1 -1.1 -19.16 -0.72 1e-55 Homoarginine levels; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.32 0.74 2.48e-60 Prudent dietary pattern; LUSC cis rs6669072 0.565 rs4658085 chr1:91266786 T/C cg08895590 chr1:91227319 NA -0.27 -5.75 -0.3 1.99e-8 Cognitive function; LUSC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg08470875 chr2:26401718 FAM59B -0.67 -8.9 -0.44 3.72e-17 Gut microbiome composition (summer); LUSC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg17644776 chr2:200775616 C2orf69 0.54 9.55 0.46 2.9e-19 Osteoporosis; LUSC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg14668632 chr7:2872130 GNA12 -0.46 -7.22 -0.37 3.54e-12 Height; LUSC cis rs3799379 0.530 rs10456045 chr6:26404958 A/G cg09904177 chr6:26538194 HMGN4 0.51 6.96 0.36 1.85e-11 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.534 rs1384860 chr12:34045388 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.77 0.51 2.06e-23 Morning vs. evening chronotype; LUSC cis rs8062405 0.721 rs151303 chr16:28492510 C/A cg16576597 chr16:28551801 NUPR1 0.3 5.99 0.31 5.56e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10754283 0.935 rs10801756 chr1:90101832 C/T cg21401794 chr1:90099060 LRRC8C 0.65 9.79 0.47 4.51e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2762353 0.935 rs1177442 chr6:25809069 A/G cg12310025 chr6:25882481 NA -0.43 -7.44 -0.38 8.82e-13 Blood metabolite levels; LUSC cis rs2130392 0.926 rs7679215 chr4:185635311 C/T cg04058563 chr4:185651563 MLF1IP -0.39 -6.56 -0.34 2.04e-10 Kawasaki disease; LUSC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg18350739 chr11:68623251 NA -0.39 -6.84 -0.35 3.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1971762 0.563 rs10747678 chr12:54077687 A/C cg23533419 chr12:54090519 NA 0.36 5.88 0.31 9.8e-9 Height; LUSC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg18681998 chr4:17616180 MED28 0.89 17.19 0.69 7.03e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 2.83e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6430585 0.527 rs2289959 chr2:136423904 C/T cg07169764 chr2:136633963 MCM6 0.95 12.81 0.57 7.61e-31 Corneal structure; LUSC cis rs2116941 1.000 rs7250265 chr19:10339818 G/C cg01850179 chr19:10340795 S1PR2 -0.73 -13.36 -0.59 6.61e-33 Pulse pressure; LUSC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg22903471 chr2:27725779 GCKR -0.4 -6.92 -0.35 2.35e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs12200782 0.505 rs1535275 chr6:26520767 G/C cg11502198 chr6:26597334 ABT1 0.91 11.21 0.52 5.77e-25 Small cell lung carcinoma; LUSC cis rs7178375 0.607 rs71474639 chr15:31213257 A/G cg03767031 chr15:31195708 MTMR15 0.77 6.8 0.35 4.81e-11 Hypertriglyceridemia; LUSC cis rs34375054 0.525 rs10846829 chr12:125595058 G/C cg09839279 chr12:125627357 AACS -0.33 -5.89 -0.31 9.51e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9486719 1.000 rs11153018 chr6:96956137 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -10.0 -0.48 9.04e-21 Migraine;Coronary artery disease; LUSC cis rs2486288 0.586 rs12909883 chr15:45572054 G/C cg09092052 chr15:45571596 NA 0.46 6.34 0.33 7.51e-10 Glomerular filtration rate; LUSC cis rs10743315 0.557 rs1552750 chr12:19356505 A/T cg02471346 chr12:19282374 PLEKHA5 0.74 5.99 0.31 5.43e-9 Gut microbiota (bacterial taxa); LUSC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11890956 chr21:40555474 PSMG1 -0.87 -15.4 -0.64 8.03e-41 Cognitive function; LUSC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg07936489 chr17:37558343 FBXL20 0.72 9.97 0.48 1.12e-20 Glomerular filtration rate (creatinine); LUSC cis rs8114671 0.562 rs6087644 chr20:33480917 G/C cg07148914 chr20:33460835 GGT7 0.52 7.53 0.38 4.77e-13 Height; LUSC cis rs9311676 0.632 rs11705721 chr3:58400414 T/C cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg13393036 chr8:95962371 TP53INP1 0.39 7.4 0.38 1.12e-12 Type 2 diabetes; LUSC trans rs459571 0.959 rs410876 chr9:136893867 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.76 -12.5 -0.56 1.13e-29 Platelet distribution width; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg04319218 chr19:11307663 KANK2 0.63 6.21 0.32 1.56e-9 Body mass index; LUSC cis rs10501293 0.529 rs2902301 chr11:43093159 A/T cg03447554 chr11:43094025 NA -0.37 -7.01 -0.36 1.36e-11 Cognitive performance; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg16145915 chr7:1198662 ZFAND2A -0.6 -11.13 -0.52 1.12e-24 Longevity;Endometriosis; LUSC trans rs7618501 0.573 rs7634917 chr3:50049299 T/G cg21659725 chr3:3221576 CRBN -0.64 -10.71 -0.51 3.44e-23 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg08470875 chr2:26401718 FAM59B -0.7 -9.38 -0.46 1.07e-18 Gut microbiome composition (summer); LUSC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg00509249 chr6:109615579 CCDC162 -0.33 -5.9 -0.31 9.08e-9 Reticulocyte fraction of red cells; LUSC trans rs979233 0.502 rs276277 chr5:42076852 T/A cg07010552 chr17:7358735 CHRNB1 -0.41 -6.09 -0.32 3.06e-9 Systemic lupus erythematosus; LUSC cis rs11158026 0.603 rs8020545 chr14:55409070 T/A cg04306507 chr14:55594613 LGALS3 0.36 6.47 0.33 3.44e-10 Parkinson's disease; LUSC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg01879757 chr17:41196368 BRCA1 0.45 7.32 0.37 1.84e-12 Menopause (age at onset); LUSC trans rs57221529 0.713 rs12521091 chr5:590710 G/T cg25482853 chr8:67687455 SGK3 1.19 16.05 0.66 2.21e-43 Lung disease severity in cystic fibrosis; LUSC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg07343612 chr16:622815 PIGQ -0.72 -12.16 -0.55 2e-28 Height; LUSC cis rs7712401 0.655 rs6884312 chr5:122103977 A/C cg19077854 chr5:122220652 SNX24 0.31 6.97 0.36 1.75e-11 Mean platelet volume; LUSC cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg20887711 chr4:1340912 KIAA1530 0.41 6.26 0.32 1.16e-9 Obesity-related traits; LUSC cis rs9807989 0.507 rs3213732 chr2:102998279 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.27e-12 Asthma; LUSC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg17633681 chr16:88106987 BANP 0.5 9.19 0.45 4.32e-18 Menopause (age at onset); LUSC cis rs7815909 0.604 rs73679807 chr8:57202782 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.6 6.86 0.35 3.39e-11 Height; LUSC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg14552801 chr7:65878734 NA -0.45 -6.52 -0.34 2.6e-10 Aortic root size; LUSC cis rs1577917 0.958 rs12197463 chr6:86445242 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.69e-11 Response to antipsychotic treatment; LUSC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg15445000 chr17:37608096 MED1 -0.39 -6.69 -0.34 9.29e-11 Glomerular filtration rate (creatinine); LUSC cis rs2853333 1.000 rs2853336 chr19:35746799 G/A cg12287945 chr19:35758300 LSR -0.37 -5.87 -0.31 1.05e-8 Red blood cell count; LUSC cis rs782590 0.935 rs782652 chr2:55862775 C/A cg18811423 chr2:55921094 PNPT1 0.83 14.37 0.62 8.77e-37 Metabolic syndrome; LUSC trans rs41419946 1.000 rs12072131 chr1:165397025 G/A cg06650914 chr18:74208293 NA 0.66 6.21 0.32 1.55e-9 Gut microbiome composition (winter); LUSC cis rs6456156 0.586 rs7762156 chr6:167485831 A/T cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC trans rs61931739 0.534 rs1352207 chr12:34036862 C/T cg26384229 chr12:38710491 ALG10B -0.64 -10.07 -0.48 5.39e-21 Morning vs. evening chronotype; LUSC cis rs734999 0.505 rs60687045 chr1:2539603 G/A cg18854424 chr1:2615690 NA 0.51 10.14 0.49 3e-21 Ulcerative colitis; LUSC cis rs4478137 0.501 rs7657483 chr4:164232102 T/C cg06758707 chr4:164254230 NPY1R -0.51 -6.79 -0.35 5.2e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs3862030 0.720 rs7081467 chr10:104231662 G/C cg22532475 chr10:104410764 TRIM8 0.24 5.64 0.3 3.58e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg21171335 chr12:122356390 WDR66 0.63 9.31 0.45 1.82e-18 Mean corpuscular volume; LUSC cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.44 0.38 8.79e-13 Motion sickness; LUSC cis rs9329289 0.510 rs35854428 chr10:2554280 T/C cg15501526 chr10:2543763 NA 0.53 9.3 0.45 1.89e-18 Age-related hearing impairment; LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4285028 0.747 rs4048699 chr3:121404483 A/G cg11130432 chr3:121712080 ILDR1 0.53 8.06 0.4 1.37e-14 Multiple sclerosis; LUSC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg18230493 chr5:56204884 C5orf35 -0.66 -10.15 -0.49 2.81e-21 Coronary artery disease; LUSC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg07701084 chr6:150067640 NUP43 0.57 8.92 0.44 3.05e-17 Lung cancer; LUSC cis rs244293 1.000 rs244286 chr17:53232594 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.7 -0.3 2.68e-8 Menarche (age at onset); LUSC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg02187348 chr16:89574699 SPG7 0.49 7.59 0.38 3.22e-13 Multiple myeloma (IgH translocation); LUSC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg16447950 chr5:562315 NA -0.57 -6.95 -0.36 1.97e-11 Lung disease severity in cystic fibrosis; LUSC cis rs3540 0.576 rs1974519 chr15:91036460 A/G cg22089800 chr15:90895588 ZNF774 0.63 9.42 0.46 7.97e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs56283067 0.847 rs62435998 chr6:44695206 C/T cg20913747 chr6:44695427 NA -0.48 -7.75 -0.39 1.12e-13 Total body bone mineral density; LUSC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg11301795 chr4:187892539 NA -0.77 -15.04 -0.64 2.04e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg09034736 chr1:150693464 HORMAD1 0.43 6.3 0.33 9.53e-10 Melanoma; LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg04267008 chr7:1944627 MAD1L1 -0.56 -8.34 -0.42 1.95e-15 Bipolar disorder and schizophrenia; LUSC cis rs925255 0.810 rs2048240 chr2:28640327 C/T cg01273330 chr2:28605224 NA -0.38 -6.15 -0.32 2.27e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg16228356 chr17:43848958 NA 0.28 6.42 0.33 4.67e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7851660 0.967 rs7847126 chr9:100600635 A/C cg13688889 chr9:100608707 NA -0.61 -10.55 -0.5 1.19e-22 Strep throat; LUSC cis rs12200560 0.524 rs1413525 chr6:97073096 C/T cg06623918 chr6:96969491 KIAA0776 0.5 7.06 0.36 9.85e-12 Coronary heart disease; LUSC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg27170947 chr2:26402098 FAM59B -0.63 -9.27 -0.45 2.44e-18 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.14 0.41 8.18e-15 Prudent dietary pattern; LUSC cis rs477692 0.905 rs509041 chr10:131424948 A/G cg26102564 chr10:131424627 MGMT 0.37 5.79 0.3 1.59e-8 Response to temozolomide; LUSC trans rs62238980 0.614 rs78680556 chr22:32395329 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs11039798 1.000 rs11039904 chr11:48682597 T/A cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.56e-24 Aortic root size; LUSC trans rs12579753 1.000 rs2401004 chr12:82214822 T/C cg07923666 chr12:49932857 KCNH3 -0.51 -6.33 -0.33 7.74e-10 Resting heart rate; LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg04518342 chr5:131593106 PDLIM4 0.45 7.93 0.4 3.23e-14 Breast cancer; LUSC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg12963246 chr6:28129442 ZNF389 0.51 7.35 0.37 1.52e-12 Parkinson's disease; LUSC cis rs6964587 0.626 rs6979235 chr7:91511776 T/C cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs12478296 1.000 rs12478296 chr2:243048760 A/G cg06360820 chr2:242988706 NA 0.72 8.4 0.42 1.29e-15 Obesity-related traits; LUSC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg16524733 chr11:117070046 TAGLN 0.41 6.63 0.34 1.37e-10 Blood protein levels; LUSC cis rs6142102 0.923 rs6059635 chr20:32613493 A/T cg08999081 chr20:33150536 PIGU 0.36 6.39 0.33 5.58e-10 Skin pigmentation; LUSC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11644478 chr21:40555479 PSMG1 -0.64 -9.81 -0.47 3.84e-20 Menarche (age at onset); LUSC cis rs11583043 0.793 rs3903905 chr1:101420957 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.85 0.35 3.59e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg23711669 chr6:146136114 FBXO30 0.83 14.81 0.63 1.69e-38 Lobe attachment (rater-scored or self-reported); LUSC trans rs9951602 0.512 rs9304070 chr18:76654890 A/C cg02800362 chr5:177631904 HNRNPAB 0.85 12.83 0.57 6.81e-31 Obesity-related traits; LUSC cis rs727505 1.000 rs66513837 chr7:124492763 A/G cg23710748 chr7:124431027 NA -0.42 -7.47 -0.38 6.9e-13 Lewy body disease; LUSC cis rs6500395 0.962 rs1386042 chr16:48600332 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.94e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1003719 0.737 rs2835587 chr21:38461795 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.29 0.53 3.03e-25 Eye color traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24283186 chr10:49514530 NA -0.4 -6.08 -0.32 3.2e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg00031303 chr3:195681400 NA 0.69 9.87 0.48 2.5e-20 Pancreatic cancer; LUSC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg18681998 chr4:17616180 MED28 0.79 14.0 0.61 2.26e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg21862992 chr11:68658383 NA -0.47 -7.58 -0.38 3.47e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg16606324 chr3:10149918 C3orf24 0.59 7.91 0.4 3.85e-14 Alzheimer's disease; LUSC cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC trans rs7829975 0.806 rs2428 chr8:8641145 C/T cg21775007 chr8:11205619 TDH 0.47 6.81 0.35 4.56e-11 Mood instability; LUSC cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg02527881 chr3:46936655 PTH1R -0.41 -7.41 -0.38 1.04e-12 Colorectal cancer; LUSC cis rs7428 0.545 rs9248 chr2:85537312 G/A cg24342717 chr2:85555507 TGOLN2 -0.73 -11.65 -0.54 1.44e-26 Ear protrusion; LUSC trans rs11039798 0.841 rs11039783 chr11:48526828 G/C cg03929089 chr4:120376271 NA 0.65 6.05 0.31 3.79e-9 Axial length; LUSC cis rs2289328 0.943 rs3803360 chr15:40662669 C/T cg13931752 chr15:40660718 DISP2 0.45 6.33 0.33 7.84e-10 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg06784218 chr1:46089804 CCDC17 -0.46 -8.78 -0.43 8.85e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg24675658 chr1:53192096 ZYG11B -0.7 -11.57 -0.53 2.96e-26 Monocyte count; LUSC trans rs6598955 0.572 rs6598951 chr1:26592714 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.65 -9.0 -0.44 1.7e-17 Obesity-related traits; LUSC cis rs7103648 0.742 rs34937994 chr11:47389638 C/T cg20307385 chr11:47447363 PSMC3 0.89 15.53 0.65 2.62e-41 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs1570884 0.516 rs9526580 chr13:50164023 C/G cg08779649 chr13:50194554 NA -0.37 -6.28 -0.33 1.04e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 8.01 0.4 1.93e-14 Lung cancer; LUSC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg10523679 chr1:76189770 ACADM -0.81 -10.99 -0.52 3.55e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg04539111 chr16:67997858 SLC12A4 -0.47 -6.3 -0.33 9.58e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs3818285 0.504 rs4917547 chr10:111652285 T/C cg00817464 chr10:111662876 XPNPEP1 -0.59 -8.27 -0.41 3.13e-15 Superior crus of antihelix expression; LUSC cis rs7937682 0.855 rs11213985 chr11:111581521 C/A cg09085632 chr11:111637200 PPP2R1B -1.14 -19.47 -0.73 5.97e-57 Primary sclerosing cholangitis; LUSC cis rs977987 0.843 rs10459859 chr16:75381950 T/C cg03315344 chr16:75512273 CHST6 0.55 10.61 0.5 7.14e-23 Dupuytren's disease; LUSC cis rs7582180 0.585 rs13031711 chr2:100939433 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.35 -0.42 1.82e-15 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg00933542 chr6:150070202 PCMT1 0.3 6.07 0.32 3.39e-9 Lung cancer; LUSC cis rs61931739 0.517 rs10844727 chr12:34017435 C/T cg06521331 chr12:34319734 NA -0.51 -8.3 -0.41 2.61e-15 Morning vs. evening chronotype; LUSC trans rs8073060 0.963 rs4795082 chr17:33873501 C/T cg19694781 chr19:47549865 TMEM160 0.68 10.42 0.5 3.42e-22 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs35110281 0.633 rs2329593 chr21:45121987 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.6 0.5 8.01e-23 Mean corpuscular volume; LUSC cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg23711669 chr6:146136114 FBXO30 0.79 14.43 0.62 4.95e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs7512552 0.839 rs11581351 chr1:150440200 G/C cg15654264 chr1:150340011 RPRD2 0.65 10.76 0.51 2.24e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -7.55 -0.38 4.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg05802129 chr4:122689817 NA -0.52 -8.96 -0.44 2.26e-17 Type 2 diabetes; LUSC cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg26647111 chr11:31128758 NA -0.42 -6.19 -0.32 1.77e-9 Red blood cell count; LUSC cis rs17102423 0.654 rs8008095 chr14:65525794 A/G cg11161011 chr14:65562177 MAX -0.58 -9.02 -0.44 1.46e-17 Obesity-related traits; LUSC trans rs4734806 0.579 rs72677050 chr8:105872590 T/G cg19267248 chr12:98849532 NA 0.39 6.08 0.32 3.37e-9 Periodontitis (DPAL); LUSC trans rs12571093 0.803 rs61854839 chr10:70044616 T/C cg04882175 chr6:131122610 NA -0.56 -6.22 -0.32 1.46e-9 Optic nerve measurement (disc area); LUSC cis rs1949733 0.701 rs4696828 chr4:8455604 G/A cg13073564 chr4:8508604 NA 0.44 8.32 0.41 2.25e-15 Response to antineoplastic agents; LUSC cis rs7945705 0.875 rs10769957 chr11:8809016 A/C cg09997546 chr11:8931473 C11orf17;ST5 -0.32 -6.3 -0.33 9.65e-10 Hemoglobin concentration; LUSC cis rs117623576 0.941 rs211423 chr10:32398777 A/G cg03047570 chr10:32398778 NA 0.73 7.86 0.4 5.39e-14 Anti-saccade response; LUSC cis rs7267979 1.000 rs2500404 chr20:25359758 A/C cg08601574 chr20:25228251 PYGB -0.43 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3820068 0.705 rs4646083 chr1:15825564 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.3 1.45e-8 Systolic blood pressure; LUSC cis rs67072384 1.000 rs12272109 chr11:72453850 G/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9303542 0.625 rs8072250 chr17:46569216 C/T cg09704116 chr17:46666958 LOC404266 -0.32 -5.84 -0.3 1.22e-8 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs61931739 0.817 rs7963318 chr12:34244929 C/G cg06521331 chr12:34319734 NA 0.38 6.62 0.34 1.47e-10 Morning vs. evening chronotype; LUSC trans rs1927790 0.727 rs9556551 chr13:96947223 T/A cg03198741 chr6:1003969 LOC285768 -0.4 -6.09 -0.32 3.08e-9 Body mass index; LUSC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg17971929 chr21:40555470 PSMG1 0.78 13.94 0.61 4.02e-35 Cognitive function; LUSC cis rs240764 0.817 rs240115 chr6:101053069 T/C cg09795085 chr6:101329169 ASCC3 0.41 6.01 0.31 4.84e-9 Neuroticism; LUSC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg12334488 chr2:20871173 GDF7 -0.34 -6.12 -0.32 2.64e-9 Abdominal aortic aneurysm; LUSC cis rs6089584 0.526 rs6089619 chr20:60610916 C/T cg24733560 chr20:60626293 TAF4 0.42 7.65 0.39 2.11e-13 Body mass index; LUSC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg05425664 chr17:57184151 TRIM37 -0.55 -8.21 -0.41 4.91e-15 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.692 rs55676827 chr15:76961716 C/T cg22467129 chr15:76604101 ETFA -0.43 -6.8 -0.35 4.87e-11 Blood metabolite levels; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg25428297 chr7:1022841 CYP2W1 0.27 5.68 0.3 3e-8 Longevity;Endometriosis; LUSC cis rs7973719 0.865 rs12830671 chr12:7347278 T/G cg07052231 chr12:7363540 PEX5 0.53 9.07 0.44 1.05e-17 IgG glycosylation; LUSC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC cis rs10761482 0.817 rs2061484 chr10:62105498 A/C cg18175470 chr10:62150864 ANK3 -0.5 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs10865050 1 rs10865050 chr2:102941311 G/A cg20060108 chr2:102954350 IL1RL1 0.48 6.37 0.33 6.4e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9534288 0.659 rs1581846 chr13:46650686 G/A cg15192986 chr13:46630673 CPB2 -0.76 -11.6 -0.54 2.26e-26 Blood protein levels; LUSC trans rs115986297 0.559 rs3800159 chr6:2130774 C/T cg23705487 chr8:91013396 DECR1 -0.49 -6.16 -0.32 2.09e-9 Hematocrit;Hemoglobin concentration;Red blood cell count; LUSC cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.74 -0.51 2.59e-23 Chronic sinus infection; LUSC cis rs2204008 0.548 rs8189475 chr12:38037115 C/T cg26384229 chr12:38710491 ALG10B 0.83 13.91 0.61 5.01e-35 Bladder cancer; LUSC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg11062466 chr8:58055876 NA 0.49 6.34 0.33 7.38e-10 Developmental language disorder (linguistic errors); LUSC cis rs11792861 0.851 rs17552292 chr9:111891954 C/T cg13535736 chr9:111863775 C9orf5 -0.41 -6.8 -0.35 4.87e-11 Menarche (age at onset); LUSC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg07701084 chr6:150067640 NUP43 0.57 8.68 0.43 1.74e-16 Lung cancer; LUSC cis rs4862307 0.688 rs6552741 chr4:184990335 A/G cg06737308 chr4:185021514 ENPP6 -0.44 -6.65 -0.34 1.17e-10 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs868036 0.958 rs4261478 chr15:68074084 G/A cg05925327 chr15:68127851 NA -0.34 -6.05 -0.31 3.8e-9 Restless legs syndrome; LUSC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.19 0.32 1.8e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.646 rs13103430 chr4:17567355 A/C cg18681998 chr4:17616180 MED28 -0.74 -10.7 -0.51 3.69e-23 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg08999081 chr20:33150536 PIGU 0.44 8.2 0.41 5.25e-15 Coronary artery disease; LUSC cis rs988712 0.672 rs925947 chr11:27667367 G/T cg10635145 chr11:27742435 BDNF -0.46 -5.96 -0.31 6.27e-9 Obesity; LUSC cis rs2204008 0.545 rs1663283 chr12:38132039 G/A cg13010199 chr12:38710504 ALG10B -0.53 -7.94 -0.4 3.15e-14 Bladder cancer; LUSC cis rs10979 0.679 rs35914889 chr6:143886392 A/T cg25407410 chr6:143891975 LOC285740 -0.69 -9.45 -0.46 5.92e-19 Hypospadias; LUSC trans rs9329221 0.686 rs13264580 chr8:10250699 C/T cg08975724 chr8:8085496 FLJ10661 0.47 6.14 0.32 2.36e-9 Neuroticism; LUSC cis rs142518269 1 rs142518269 chr2:24087095 G/A cg20701182 chr2:24300061 SF3B14 0.73 7.33 0.37 1.74e-12 Mean corpuscular hemoglobin; LUSC cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg14844989 chr11:31128820 NA -0.37 -5.79 -0.3 1.67e-8 Red blood cell count; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg15242686 chr22:24348715 GSTTP1 -0.42 -6.37 -0.33 6.16e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22450460 chr6:7389544 CAGE1;RIOK1 -0.46 -6.36 -0.33 6.74e-10 Hepatitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26776742 chr6:117002360 KPNA5 -0.44 -6.58 -0.34 1.87e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4356932 0.691 rs10008757 chr4:76903036 A/G cg00809888 chr4:76862425 NAAA 0.37 5.88 0.31 9.75e-9 Blood protein levels; LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg21782813 chr7:2030301 MAD1L1 0.54 9.26 0.45 2.61e-18 Bipolar disorder and schizophrenia; LUSC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg12463550 chr7:65579703 CRCP -0.56 -8.33 -0.41 2.14e-15 Aortic root size; LUSC cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.35 -0.46 1.28e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1371867 0.846 rs1613453 chr8:101244215 G/T cg06002616 chr8:101225028 SPAG1 0.45 7.39 0.37 1.23e-12 Atrioventricular conduction; LUSC cis rs9479482 0.967 rs11752529 chr6:150347971 C/T cg25797454 chr6:150327115 RAET1K 0.36 8.18 0.41 5.97e-15 Alopecia areata; LUSC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg27494647 chr7:150038898 RARRES2 0.44 6.75 0.35 6.37e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg18306943 chr3:40428807 ENTPD3 0.4 5.96 0.31 6.5e-9 Renal cell carcinoma; LUSC cis rs425277 1.000 rs262647 chr1:2095699 C/T cg03732007 chr1:2071316 PRKCZ 0.47 7.61 0.38 2.8e-13 Height; LUSC cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg04450456 chr4:17643702 FAM184B 0.38 6.24 0.32 1.29e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs912057 0.901 rs744056 chr6:6733540 A/G cg06612196 chr6:6737390 NA 0.51 9.71 0.47 8.55e-20 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs2760061 0.819 rs708120 chr1:228207651 G/C cg01973587 chr1:228161476 NA -0.4 -7.03 -0.36 1.18e-11 Diastolic blood pressure; LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.63 0.47 1.61e-19 Bipolar disorder; LUSC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg03929089 chr4:120376271 NA -0.98 -16.38 -0.67 1.14e-44 Coronary artery disease; LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg12564285 chr5:131593104 PDLIM4 -0.47 -8.21 -0.41 4.79e-15 Breast cancer; LUSC cis rs7647973 0.961 rs11130187 chr3:49307872 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.46 6.96 0.36 1.77e-11 Menarche (age at onset); LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg13560548 chr3:10150139 C3orf24 0.54 7.74 0.39 1.17e-13 Alzheimer's disease; LUSC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg06636001 chr8:8085503 FLJ10661 0.57 8.24 0.41 4.06e-15 Neuroticism; LUSC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg15448220 chr1:150897856 SETDB1 0.42 6.06 0.31 3.68e-9 Melanoma; LUSC cis rs9649465 0.561 rs631445 chr7:123413707 C/T cg03229431 chr7:123269106 ASB15 -0.48 -7.79 -0.39 8.65e-14 Migraine; LUSC cis rs10761482 0.515 rs2393642 chr10:62282490 G/A cg18175470 chr10:62150864 ANK3 -0.51 -7.25 -0.37 2.95e-12 Schizophrenia; LUSC trans rs7939886 0.920 rs17150117 chr11:55941186 T/C cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC cis rs62400317 0.859 rs12211519 chr6:45160530 C/A cg18551225 chr6:44695536 NA -0.45 -7.22 -0.37 3.47e-12 Total body bone mineral density; LUSC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg17179660 chr6:151773299 C6orf211;RMND1 0.46 6.88 0.35 2.9e-11 Menarche (age at onset); LUSC cis rs7202877 0.706 rs42472 chr16:75473320 T/A cg04384234 chr16:75411784 CFDP1 0.67 9.18 0.45 4.7e-18 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9325144 0.555 rs4882359 chr12:38726679 T/C cg13010199 chr12:38710504 ALG10B 0.47 7.27 0.37 2.56e-12 Morning vs. evening chronotype; LUSC trans rs11123259 0.794 rs11691241 chr2:115690810 T/C cg00844339 chr9:138873417 NA 0.3 6.0 0.31 5.15e-9 Gut microbiome composition (winter); LUSC cis rs2439831 0.850 rs694985 chr15:43813387 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.77 7.9 0.4 4.09e-14 Lung cancer in ever smokers; LUSC cis rs6087990 0.965 rs742630 chr20:31350664 C/G cg13636640 chr20:31349939 DNMT3B 1.05 24.37 0.8 4.18e-76 Ulcerative colitis; LUSC cis rs12594515 1.000 rs7173144 chr15:45991196 A/G cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg17971929 chr21:40555470 PSMG1 0.79 13.89 0.61 6.06e-35 Cognitive function; LUSC cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 13.13 0.58 4.69e-32 Chronic sinus infection; LUSC cis rs6665290 0.904 rs11586604 chr1:227183865 G/T cg10327440 chr1:227177885 CDC42BPA -1.21 -40.08 -0.91 1.14e-129 Myeloid white cell count; LUSC cis rs17621444 0.522 rs10788024 chr10:121817172 C/T cg02041677 chr10:121771263 NA -0.32 -6.22 -0.32 1.52e-9 IgG glycosylation; LUSC cis rs7527798 0.592 rs4097398 chr1:207857760 C/T cg09232269 chr1:207846808 CR1L -0.31 -6.71 -0.34 8.55e-11 Erythrocyte sedimentation rate; LUSC cis rs12980942 0.810 rs12974323 chr19:41807071 A/G cg25627403 chr19:41769009 HNRNPUL1 0.62 6.77 0.35 5.89e-11 Coronary artery disease; LUSC cis rs76793172 1.000 rs28433213 chr19:46341168 C/T cg00442267 chr19:46317840 RSPH6A -0.5 -5.7 -0.3 2.66e-8 Eosinophil counts; LUSC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg05855489 chr10:104503620 C10orf26 -0.76 -12.87 -0.58 4.64e-31 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs662064 0.962 rs648399 chr1:10556485 T/C cg17425144 chr1:10567563 PEX14 0.35 5.66 0.3 3.25e-8 Asthma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04977610 chr16:30366665 CD2BP2 -0.45 -6.04 -0.31 4.06e-9 Bipolar disorder and schizophrenia; LUSC trans rs8073060 0.614 rs72829932 chr17:34055935 A/G cg19694781 chr19:47549865 TMEM160 1.12 17.82 0.7 2.09e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11890956 chr21:40555474 PSMG1 -0.9 -16.31 -0.67 2.2e-44 Cognitive function; LUSC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg06022373 chr22:39101656 GTPBP1 0.85 14.22 0.61 3.23e-36 Menopause (age at onset); LUSC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs2257432 chr20:25271086 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.46 0.75 6.72e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg14895029 chr7:2775587 GNA12 -0.41 -6.06 -0.31 3.58e-9 Height; LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4792901 0.802 rs12602059 chr17:41573730 A/G cg22562494 chr17:41607896 ETV4 -0.33 -6.06 -0.31 3.59e-9 Dupuytren's disease; LUSC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs9902453 0.900 rs56195309 chr17:28453753 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 8.08 0.4 1.17e-14 Coffee consumption (cups per day); LUSC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg08392591 chr16:89556376 ANKRD11 0.47 7.19 0.37 4.28e-12 Multiple myeloma (IgH translocation); LUSC cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 8.09 0.4 1.14e-14 Lung cancer; LUSC cis rs4629710 0.568 rs67021539 chr6:131552900 A/G cg12700074 chr6:131571435 AKAP7 -0.36 -5.95 -0.31 6.86e-9 Multiple myeloma (IgH translocation); LUSC cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.89 -0.4 4.49e-14 Chronic sinus infection; LUSC cis rs2273669 0.667 rs7761290 chr6:109326621 T/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs7923609 0.967 rs7909269 chr10:65177766 G/A cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg08999081 chr20:33150536 PIGU 0.37 6.69 0.34 9.61e-11 Height; LUSC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg17143192 chr8:8559678 CLDN23 0.63 9.14 0.45 6.03e-18 Obesity-related traits; LUSC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC cis rs7296418 0.663 rs28450974 chr12:123861420 G/A cg00376283 chr12:123451042 ABCB9 0.72 10.87 0.51 9.46e-24 Platelet count; LUSC cis rs7100689 0.646 rs1290317 chr10:82062531 C/A cg01528321 chr10:82214614 TSPAN14 0.83 12.44 0.56 1.93e-29 Post bronchodilator FEV1; LUSC cis rs9399135 0.967 rs4376365 chr6:135307740 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.11 0.45 7.57e-18 Red blood cell count; LUSC cis rs4363385 0.647 rs56158137 chr1:152994380 A/T cg00922841 chr1:152955080 SPRR1A -0.4 -6.54 -0.34 2.3e-10 Inflammatory skin disease; LUSC cis rs3820928 0.839 rs13404750 chr2:227876129 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.77 -0.39 1e-13 Pulmonary function; LUSC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg00033643 chr7:134001901 SLC35B4 0.43 6.81 0.35 4.42e-11 Mean platelet volume; LUSC trans rs2204008 0.502 rs2387275 chr12:38142836 G/A cg06521331 chr12:34319734 NA -0.4 -6.03 -0.31 4.26e-9 Bladder cancer; LUSC trans rs7726558 0.731 rs3756513 chr5:118832965 C/G cg14402224 chr7:50570049 DDC -0.48 -6.12 -0.32 2.57e-9 QT interval (sulfonylurea treatment interaction); LUSC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg00166722 chr3:10149974 C3orf24 0.39 5.84 0.3 1.24e-8 Alzheimer's disease; LUSC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.72 9.55 0.46 2.8e-19 Schizophrenia; LUSC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg26408565 chr15:76604113 ETFA -0.5 -8.02 -0.4 1.82e-14 Blood metabolite levels; LUSC cis rs1018836 0.923 rs13262354 chr8:91635731 G/A cg16814680 chr8:91681699 NA -0.76 -12.59 -0.57 5.34e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs113835537 0.597 rs10896129 chr11:66338300 T/C cg24851651 chr11:66362959 CCS 0.58 9.04 0.44 1.28e-17 Airway imaging phenotypes; LUSC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs12310956 0.532 rs7955514 chr12:33978737 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.37 0.42 1.56e-15 Morning vs. evening chronotype; LUSC cis rs611744 0.647 rs647907 chr8:109251374 T/C cg21045802 chr8:109455806 TTC35 0.43 6.6 0.34 1.58e-10 Dupuytren's disease; LUSC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg04369109 chr6:150039330 LATS1 -0.56 -8.17 -0.41 6.41e-15 Lung cancer; LUSC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.63 13.9 0.61 5.42e-35 Hemoglobin concentration; LUSC cis rs3091242 0.933 rs1534954 chr1:25761924 A/T cg02931644 chr1:25747376 RHCE 0.34 6.2 0.32 1.65e-9 Erythrocyte sedimentation rate; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.6 9.81 0.47 3.81e-20 Lymphocyte counts; LUSC cis rs3768617 0.510 rs10797839 chr1:183077797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.59e-24 Fuchs's corneal dystrophy; LUSC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 15.02 0.64 2.48e-39 Platelet count; LUSC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg21672276 chr3:44754072 ZNF502 -0.39 -6.33 -0.33 7.75e-10 Depressive symptoms; LUSC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg08773314 chr2:239334832 ASB1 0.38 6.92 0.35 2.28e-11 Multiple system atrophy; LUSC cis rs7267979 1.000 rs884613 chr20:25288505 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.51 -0.34 2.68e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9549367 0.789 rs12869947 chr13:113896156 A/G cg18105134 chr13:113819100 PROZ -0.69 -10.24 -0.49 1.43e-21 Platelet distribution width; LUSC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg05110241 chr16:68378359 PRMT7 -0.58 -6.68 -0.34 1.02e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.546 rs13149516 chr4:98913030 T/A cg03676636 chr4:99064102 C4orf37 0.3 6.11 0.32 2.75e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9522267 0.535 rs9522301 chr13:112236726 A/T cg10483660 chr13:112241077 NA -0.31 -5.7 -0.3 2.68e-8 Hepatitis; LUSC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.76 9.92 0.48 1.75e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1499972 0.941 rs62264782 chr3:117655445 C/A cg07612923 chr3:117604196 NA 0.65 5.85 0.3 1.18e-8 Schizophrenia; LUSC cis rs13223928 0.516 rs11763949 chr7:3150279 A/C cg19214707 chr7:3157722 NA -0.46 -8.79 -0.43 8.3e-17 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs782590 0.774 rs782629 chr2:55900283 C/T cg18811423 chr2:55921094 PNPT1 -0.86 -15.31 -0.64 1.79e-40 Metabolic syndrome; LUSC cis rs62400317 0.859 rs58769170 chr6:45298531 C/T cg20913747 chr6:44695427 NA -0.47 -7.72 -0.39 1.35e-13 Total body bone mineral density; LUSC cis rs5758511 0.680 rs1033459 chr22:42619067 A/G cg12850546 chr22:42539477 CYP2D7P1 -0.47 -5.83 -0.3 1.31e-8 Birth weight; LUSC cis rs9326248 0.530 rs11216171 chr11:116749113 T/A cg26566898 chr11:117069891 TAGLN 0.4 6.85 0.35 3.67e-11 Blood protein levels; LUSC cis rs2760061 0.846 rs3094912 chr1:228209815 T/A cg02753203 chr1:228287806 NA 0.71 12.42 0.56 2.25e-29 Diastolic blood pressure; LUSC trans rs11098499 0.739 rs7441137 chr4:120133221 G/T cg25214090 chr10:38739885 LOC399744 -0.41 -6.22 -0.32 1.52e-9 Corneal astigmatism; LUSC cis rs6961069 0.708 rs2030711 chr7:80219942 A/G cg04458919 chr7:80252533 CD36 -0.38 -6.74 -0.35 6.84e-11 Platelet count; LUSC cis rs10089 1.000 rs73337363 chr5:127483597 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.88 12.44 0.56 1.93e-29 Ileal carcinoids; LUSC cis rs9650315 0.866 rs13270709 chr8:57182507 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.8 0.35 4.85e-11 Height; LUSC trans rs8022206 0.659 rs34050208 chr14:68330633 C/T cg15809352 chr2:121748218 GLI2 0.45 6.58 0.34 1.8e-10 Platelet count;Mean platelet volume; LUSC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg04944784 chr2:26401820 FAM59B -0.71 -9.82 -0.47 3.54e-20 Gut microbiome composition (summer); LUSC cis rs4727027 0.899 rs6944096 chr7:148870026 A/G cg23583168 chr7:148888333 NA -0.92 -17.27 -0.69 3.23e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2798269 0.902 rs2476637 chr13:22112927 G/A cg18095732 chr13:22033692 ZDHHC20 -0.41 -6.31 -0.33 8.81e-10 PR segment; LUSC cis rs11711311 1.000 rs9830975 chr3:113486019 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 7.13 0.36 6.3e-12 IgG glycosylation; LUSC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.31 0.33 8.94e-10 Menopause (age at onset); LUSC cis rs68170813 0.559 rs10953532 chr7:106881808 C/T cg02696742 chr7:106810147 HBP1 -0.64 -9.65 -0.47 1.31e-19 Coronary artery disease; LUSC cis rs11190604 1.000 rs2295773 chr10:102265815 A/G cg07080220 chr10:102295463 HIF1AN 0.69 9.23 0.45 3.27e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs394563 0.967 rs444784 chr6:149798366 C/G cg11245181 chr6:149772854 ZC3H12D -0.29 -6.3 -0.33 9.58e-10 Dupuytren's disease; LUSC cis rs7659604 0.540 rs28394772 chr4:122678543 C/T cg19748678 chr4:122722346 EXOSC9 -0.4 -5.89 -0.31 9.28e-9 Type 2 diabetes; LUSC cis rs3768617 0.546 rs2296296 chr1:183105399 C/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.98 0.52 3.72e-24 Fuchs's corneal dystrophy; LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg22166914 chr1:53195759 ZYG11B 0.63 10.59 0.5 8.96e-23 Monocyte count; LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg07395648 chr5:131743802 NA -0.4 -5.92 -0.31 8.19e-9 Acylcarnitine levels; LUSC trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg17470723 chr8:74884337 TCEB1 0.52 8.11 0.41 9.95e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg20607287 chr7:12443886 VWDE -0.65 -6.47 -0.33 3.53e-10 Coronary artery disease; LUSC cis rs4144743 1.000 rs11871407 chr17:45331358 C/G cg18085866 chr17:45331354 ITGB3 -0.75 -7.95 -0.4 2.83e-14 Body mass index; LUSC cis rs10887741 0.646 rs1358863 chr10:89426508 T/G cg13926569 chr10:89418898 PAPSS2 0.33 7.08 0.36 8.39e-12 Exercise (leisure time); LUSC cis rs11779988 0.543 rs379066 chr8:17881835 T/C cg01800426 chr8:17659068 MTUS1 -0.45 -5.9 -0.31 8.81e-9 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14039463 chr1:212004169 LPGAT1 -0.43 -6.54 -0.34 2.27e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg09455208 chr3:40491958 NA 0.51 9.31 0.45 1.79e-18 Renal cell carcinoma; LUSC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1858037 0.765 rs67404371 chr2:65597271 C/A cg08085232 chr2:65598271 SPRED2 -0.4 -5.93 -0.31 7.6e-9 Rheumatoid arthritis; LUSC cis rs511515 1 rs511515 chr6:33541507 A/G cg24505687 chr6:33548425 BAK1 0.45 6.56 0.34 2.04e-10 Eosinophil counts;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC trans rs3733585 0.699 rs6449174 chr4:9966422 C/T cg26043149 chr18:55253948 FECH -0.48 -7.46 -0.38 7.31e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg02423579 chr7:2872169 GNA12 -0.38 -5.99 -0.31 5.55e-9 Height; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.82 0.39 7.14e-14 Prudent dietary pattern; LUSC cis rs1572438 0.811 rs6916756 chr6:880467 G/A cg13447295 chr6:887704 NA 0.4 6.34 0.33 7.45e-10 Aging; LUSC cis rs6087990 0.966 rs2377667 chr20:31346925 A/G cg13636640 chr20:31349939 DNMT3B 1.04 23.39 0.79 2.56e-72 Ulcerative colitis; LUSC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg15212455 chr7:39170539 POU6F2 0.65 11.29 0.53 2.84e-25 IgG glycosylation; LUSC cis rs4356932 0.691 rs2273 chr4:76889388 C/T cg00809888 chr4:76862425 NAAA -0.36 -5.85 -0.3 1.19e-8 Blood protein levels; LUSC cis rs9807989 0.765 rs13424006 chr2:102967236 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.85 0.3 1.19e-8 Asthma; LUSC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.08 15.3 0.64 2.06e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05863534 chr17:34948351 DHRS11 -0.46 -6.11 -0.32 2.77e-9 Bipolar disorder and schizophrenia; LUSC cis rs3847687 1.000 rs34853396 chr12:131519265 G/T cg25772418 chr12:131519998 GPR133 -0.27 -5.99 -0.31 5.37e-9 Longevity; LUSC cis rs7953249 0.656 rs2251468 chr12:121405126 A/C cg02403541 chr12:121454288 C12orf43 0.74 11.51 0.53 4.95e-26 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs6570726 0.875 rs1883407 chr6:145823432 T/C cg23711669 chr6:146136114 FBXO30 0.73 12.89 0.58 3.92e-31 Lobe attachment (rater-scored or self-reported); LUSC trans rs208520 0.661 rs6937856 chr6:66867468 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.94 -0.68 7.04e-47 Exhaled nitric oxide output; LUSC cis rs763121 0.819 rs5757133 chr22:38947835 A/G cg06022373 chr22:39101656 GTPBP1 -0.71 -10.83 -0.51 1.22e-23 Menopause (age at onset); LUSC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg17971929 chr21:40555470 PSMG1 -0.51 -7.63 -0.39 2.48e-13 Menarche (age at onset); LUSC cis rs2012796 0.785 rs61986599 chr14:81860917 G/A cg02996355 chr14:81879375 NA 0.57 8.2 0.41 5.11e-15 Night sleep phenotypes; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg05025164 chr4:1340916 KIAA1530 0.42 6.59 0.34 1.74e-10 Obesity-related traits; LUSC cis rs7799006 0.527 rs6967286 chr7:2212758 C/A cg03354898 chr7:1950403 MAD1L1 -0.29 -5.71 -0.3 2.44e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs7615952 0.932 rs13321217 chr3:125631771 G/A cg07211511 chr3:129823064 LOC729375 -1.17 -18.57 -0.71 2.26e-53 Blood pressure (smoking interaction); LUSC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg00409905 chr10:38381863 ZNF37A -0.38 -6.49 -0.33 3.17e-10 Extrinsic epigenetic age acceleration; LUSC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.88 14.49 0.62 2.84e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7100689 0.697 rs4934084 chr10:82116960 T/C cg01528321 chr10:82214614 TSPAN14 1.03 15.98 0.66 4.45e-43 Post bronchodilator FEV1; LUSC cis rs9399135 0.967 rs4896122 chr6:135295081 T/C cg22676075 chr6:135203613 NA 0.47 7.33 0.37 1.72e-12 Red blood cell count; LUSC cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg26395211 chr5:140044315 WDR55 -0.48 -7.51 -0.38 5.38e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs1568889 1.000 rs12790932 chr11:28046189 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 9.51 0.46 3.95e-19 Bipolar disorder; LUSC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg24549020 chr5:56110836 MAP3K1 0.5 5.7 0.3 2.58e-8 Initial pursuit acceleration; LUSC cis rs5769765 0.908 rs138889 chr22:50226673 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.46 6.86 0.35 3.42e-11 Schizophrenia; LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg18036248 chr18:55712422 NEDD4L 0.39 6.07 0.32 3.39e-9 Major depressive disorder; LUSC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.83 -0.39 6.57e-14 Height; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg17558973 chr5:37249223 C5orf42 0.32 6.06 0.31 3.72e-9 Metabolite levels (Pyroglutamine); LUSC trans rs6502050 0.835 rs7212441 chr17:80080047 T/G cg07393940 chr7:158741817 NA -0.37 -6.62 -0.34 1.46e-10 Life satisfaction; LUSC cis rs4285028 0.747 rs3732410 chr3:121415720 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -13.07 -0.58 7.96e-32 Multiple sclerosis; LUSC cis rs11190604 1.000 rs7073586 chr10:102307671 A/G cg16342193 chr10:102329863 NA -0.34 -6.39 -0.33 5.67e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg00684032 chr4:1343700 KIAA1530 0.38 6.6 0.34 1.62e-10 Obesity-related traits; LUSC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg06008330 chr7:65541103 ASL -0.4 -6.31 -0.33 8.86e-10 Aortic root size; LUSC cis rs6840360 1.000 rs10023298 chr4:152666768 A/C cg22705602 chr4:152727874 NA -0.27 -5.89 -0.31 9.43e-9 Intelligence (multi-trait analysis); LUSC trans rs7824557 0.583 rs2736292 chr8:11234500 A/T cg06636001 chr8:8085503 FLJ10661 0.51 7.95 0.4 2.94e-14 Retinal vascular caliber; LUSC cis rs11098499 0.675 rs11098534 chr4:120556772 T/G cg24375607 chr4:120327624 NA 0.72 11.5 0.53 5.4e-26 Corneal astigmatism; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg27588902 chr6:42928151 GNMT -0.3 -6.6 -0.34 1.59e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6951245 0.882 rs10252404 chr7:1209607 C/A cg03188948 chr7:1209495 NA 0.71 7.56 0.38 3.8e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7759001 0.857 rs4579353 chr6:27372490 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.72 0.3 2.31e-8 Glomerular filtration rate (creatinine); LUSC cis rs7575217 0.767 rs796064 chr2:101729682 G/A cg23907051 chr2:101730305 TBC1D8 -0.3 -8.19 -0.41 5.75e-15 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs35306767 0.623 rs56201968 chr10:1141666 A/G cg26597838 chr10:835615 NA 0.5 6.49 0.33 3.05e-10 Eosinophil percentage of granulocytes; LUSC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg17211192 chr8:82754475 SNX16 -0.59 -8.36 -0.42 1.66e-15 Diastolic blood pressure; LUSC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg23985595 chr17:80112537 CCDC57 -0.33 -6.39 -0.33 5.61e-10 Life satisfaction; LUSC cis rs9341808 0.690 rs9448909 chr6:80909031 G/A cg08355045 chr6:80787529 NA 0.59 10.22 0.49 1.64e-21 Sitting height ratio; LUSC cis rs12989701 0.877 rs35860453 chr2:127866047 C/T cg08168897 chr2:127865431 BIN1 0.73 9.5 0.46 4.08e-19 Alzheimer's disease (late onset); LUSC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg21963583 chr11:68658836 MRPL21 0.54 8.26 0.41 3.36e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs3858526 0.834 rs7125255 chr11:5980384 T/A cg05234568 chr11:5960015 NA -0.62 -8.87 -0.44 4.61e-17 DNA methylation (variation); LUSC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg18681998 chr4:17616180 MED28 0.83 15.52 0.65 2.83e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs8073060 0.544 rs225268 chr17:33966224 A/C cg19694781 chr19:47549865 TMEM160 -1.13 -17.82 -0.7 2.14e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs782590 0.764 rs2054728 chr2:55818419 C/T cg03859395 chr2:55845619 SMEK2 0.81 14.18 0.61 4.63e-36 Metabolic syndrome; LUSC cis rs11645898 0.935 rs4788614 chr16:72188828 C/T cg14768367 chr16:72042858 DHODH 0.67 7.5 0.38 5.85e-13 Blood protein levels; LUSC cis rs10911363 0.592 rs10911354 chr1:183489278 G/A cg09173681 chr1:183549694 NCF2 0.64 11.45 0.53 7.79e-26 Systemic lupus erythematosus; LUSC cis rs2324229 0.861 rs1180184 chr6:83970665 A/C cg08257003 chr6:84140564 ME1 0.27 5.87 0.31 1.03e-8 Platelet-derived growth factor BB levels; LUSC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg15445000 chr17:37608096 MED1 0.41 6.89 0.35 2.81e-11 Glomerular filtration rate (creatinine); LUSC cis rs7786808 0.536 rs4909210 chr7:158194376 T/C cg01191920 chr7:158217561 PTPRN2 -0.52 -10.8 -0.51 1.64e-23 Obesity-related traits; LUSC cis rs9399135 0.967 rs4388304 chr6:135309597 T/A cg22676075 chr6:135203613 NA 0.46 7.28 0.37 2.39e-12 Red blood cell count; LUSC cis rs2073300 0.609 rs6137939 chr20:23390206 C/T cg12062639 chr20:23401060 NAPB -0.96 -8.09 -0.4 1.12e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.12 -0.36 6.8e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs868036 0.609 rs2127163 chr15:68090842 C/T cg24579218 chr15:68104479 NA -0.4 -6.42 -0.33 4.7e-10 Restless legs syndrome; LUSC trans rs9291683 0.595 rs11731110 chr4:10037346 T/C cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 1.93e-12 Bone mineral density; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13171016 chr1:40219054 PPIE 0.5 6.15 0.32 2.19e-9 Bipolar disorder and schizophrenia; LUSC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg01475377 chr6:109611718 NA -0.37 -6.46 -0.33 3.61e-10 Reticulocyte fraction of red cells; LUSC cis rs11690935 0.851 rs6731562 chr2:172798262 T/C cg13550731 chr2:172543902 DYNC1I2 -0.74 -11.69 -0.54 1.07e-26 Schizophrenia; LUSC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg20243544 chr17:37824526 PNMT 0.5 7.2 0.37 4.09e-12 Asthma; LUSC cis rs11122272 0.603 rs2998427 chr1:231528112 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.17 -0.49 2.5e-21 Hemoglobin concentration; LUSC cis rs9902453 0.904 rs11080115 chr17:28408070 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.64 -0.5 5.89e-23 Coffee consumption (cups per day); LUSC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.58 0.46 2.24e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg23630131 chr7:65973040 NA 0.21 5.78 0.3 1.76e-8 Aortic root size; LUSC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg27286337 chr10:134555280 INPP5A 0.91 11.96 0.55 1.07e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs61931739 0.517 rs7960878 chr12:34055645 C/A cg13010199 chr12:38710504 ALG10B 0.55 8.38 0.42 1.44e-15 Morning vs. evening chronotype; LUSC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg15073853 chr19:18549131 ISYNA1 -0.33 -6.03 -0.31 4.42e-9 Breast cancer; LUSC trans rs877282 0.945 rs12776447 chr10:790625 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs947211 0.898 rs10900524 chr1:205748309 G/A cg11965913 chr1:205819406 PM20D1 0.48 6.6 0.34 1.61e-10 Parkinson's disease; LUSC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg07701084 chr6:150067640 NUP43 0.45 6.79 0.35 5.06e-11 Testicular germ cell tumor; LUSC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg16386425 chr10:429943 DIP2C -0.45 -7.23 -0.37 3.3e-12 Psychosis in Alzheimer's disease; LUSC cis rs11264213 0.579 rs7523017 chr1:36015011 C/T cg27506609 chr1:36549197 TEKT2 0.54 6.08 0.32 3.27e-9 Schizophrenia; LUSC cis rs2050392 0.789 rs303438 chr10:30733493 C/T cg25182066 chr10:30743637 MAP3K8 0.41 6.41 0.33 5.07e-10 Inflammatory bowel disease; LUSC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.52 7.91 0.4 3.81e-14 Eosinophil percentage of white cells; LUSC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg11764359 chr7:65958608 NA -0.7 -10.93 -0.51 5.65e-24 Aortic root size; LUSC cis rs8072100 0.934 rs6504872 chr17:45438952 C/T cg08085267 chr17:45401833 C17orf57 -0.65 -10.88 -0.51 8.49e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg16339924 chr4:17578868 LAP3 0.5 7.35 0.37 1.5e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2486288 0.586 rs12909883 chr15:45572054 G/C cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.77 -0.39 9.67e-14 Glomerular filtration rate; LUSC cis rs7824557 0.614 rs2736277 chr8:11218893 C/T cg21775007 chr8:11205619 TDH -0.64 -10.32 -0.49 7.48e-22 Retinal vascular caliber; LUSC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.63 -0.34 1.38e-10 Schizophrenia; LUSC cis rs7100689 0.598 rs35353819 chr10:82135737 A/G cg01528321 chr10:82214614 TSPAN14 0.86 13.12 0.58 5.51e-32 Post bronchodilator FEV1; LUSC trans rs57221529 0.766 rs72703065 chr5:588123 C/A cg11887960 chr12:57824829 NA 0.56 6.84 0.35 3.75e-11 Lung disease severity in cystic fibrosis; LUSC cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg12310025 chr6:25882481 NA -0.5 -9.09 -0.45 9.27e-18 Blood metabolite levels; LUSC trans rs634534 0.591 rs688862 chr11:65733393 A/G cg17712092 chr4:129076599 LARP1B 0.73 10.86 0.51 1.02e-23 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9527 0.615 rs12248123 chr10:104735366 A/G cg05855489 chr10:104503620 C10orf26 0.53 8.19 0.41 5.77e-15 Arsenic metabolism; LUSC trans rs72674100 1.000 rs10010759 chr4:97987227 T/C cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.24 0.32 1.29e-9 Personality dimensions; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06446895 chr17:79829189 ARHGDIA 0.41 6.41 0.33 4.84e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg22166914 chr1:53195759 ZYG11B 0.57 9.29 0.45 2.08e-18 Monocyte count; LUSC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs1577917 1.000 rs1018184 chr6:86648475 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.42 6.26 0.32 1.2e-9 Response to antipsychotic treatment; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.69 0.43 1.65e-16 Prudent dietary pattern; LUSC cis rs28595532 0.702 rs72670250 chr4:119337134 T/C cg02775129 chr4:119771670 NA -0.76 -6.32 -0.33 8.59e-10 Cannabis dependence symptom count; LUSC cis rs614226 1.000 rs1167726 chr12:120967364 A/C cg27489772 chr12:121021490 NA -0.58 -7.7 -0.39 1.54e-13 Type 1 diabetes nephropathy; LUSC cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.78 0.43 8.37e-17 Axial length; LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg15691649 chr6:25882328 NA -0.38 -6.22 -0.32 1.49e-9 Blood metabolite levels; LUSC cis rs9650657 0.707 rs2005309 chr8:10652170 T/C cg27411982 chr8:10470053 RP1L1 -0.4 -6.55 -0.34 2.15e-10 Neuroticism; LUSC cis rs1008375 0.863 rs10003291 chr4:17600728 A/C cg18681998 chr4:17616180 MED28 0.85 14.78 0.63 2.15e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8062405 0.755 rs4787457 chr16:28555400 A/G cg07382826 chr16:28625726 SULT1A1 0.28 5.81 0.3 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11031096 0.678 rs12223062 chr11:4180178 G/T cg18678763 chr11:4115507 RRM1 -0.4 -5.67 -0.3 3.07e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg18681998 chr4:17616180 MED28 0.83 15.27 0.64 2.61e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg01802117 chr1:53393560 SCP2 0.38 6.14 0.32 2.4e-9 Monocyte count; LUSC cis rs4343996 0.967 rs4722663 chr7:3350567 C/T cg21248987 chr7:3385318 SDK1 -0.37 -6.37 -0.33 6.2e-10 Motion sickness; LUSC trans rs61931739 0.782 rs451940 chr12:34196005 T/C cg24313572 chr1:56050060 NA -0.29 -5.95 -0.31 6.66e-9 Morning vs. evening chronotype; LUSC cis rs9447004 0.583 rs28360541 chr6:74432427 T/G cg03006477 chr6:74432658 CD109 0.29 6.04 0.31 4e-9 Blood protein levels;Calcium levels; LUSC trans rs1351696 1 rs1351696 chr11:48382471 A/G cg03929089 chr4:120376271 NA -0.64 -5.98 -0.31 5.65e-9 D-dimer levels; LUSC cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg13010199 chr12:38710504 ALG10B 0.62 9.23 0.45 3.3e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.74 -0.51 2.64e-23 Chronic sinus infection; LUSC cis rs11971779 0.838 rs58074268 chr7:139108925 C/T cg07862535 chr7:139043722 LUC7L2 0.7 8.37 0.42 1.57e-15 Diisocyanate-induced asthma; LUSC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg04865166 chr7:105162814 PUS7 0.52 5.71 0.3 2.51e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2235649 0.833 rs7190337 chr16:1850469 A/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.0 -0.31 5.27e-9 Blood metabolite levels; LUSC cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg06191203 chr2:152266755 RIF1 -0.55 -7.27 -0.37 2.51e-12 Lung cancer; LUSC cis rs9467773 0.967 rs6456732 chr6:26514445 T/C cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.45e-42 Intelligence (multi-trait analysis); LUSC trans rs2832077 0.689 rs2832052 chr21:30130073 G/C cg14791747 chr16:20752902 THUMPD1 0.74 10.51 0.5 1.6400000000000001e-22 Cognitive test performance; LUSC cis rs147120681 1 rs147120681 chr1:101239293 CT/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.49 -7.0 -0.36 1.41e-11 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs9549367 0.756 rs2316463 chr13:113901406 C/T cg18105134 chr13:113819100 PROZ -0.67 -9.45 -0.46 6.04e-19 Platelet distribution width; LUSC cis rs941408 0.515 rs759067 chr19:2775668 C/T cg02580895 chr19:2754563 NA -0.46 -6.79 -0.35 5.13e-11 Total cholesterol levels; LUSC cis rs2625529 0.824 rs4777480 chr15:72328997 A/C cg16672083 chr15:72433130 SENP8 -0.52 -7.57 -0.38 3.79e-13 Red blood cell count; LUSC cis rs1044826 0.913 rs12488939 chr3:139050831 C/T cg00490450 chr3:139108681 COPB2 0.55 7.31 0.37 1.99e-12 Obesity-related traits; LUSC cis rs11711311 1.000 rs12736 chr3:113530211 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.41 -5.73 -0.3 2.26e-8 IgG glycosylation; LUSC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg11812906 chr14:75593930 NEK9 -0.66 -11.23 -0.52 4.83e-25 Height; LUSC cis rs500891 0.693 rs1144190 chr6:83981858 C/T cg08257003 chr6:84140564 ME1 0.33 7.35 0.37 1.56e-12 Platelet-derived growth factor BB levels; LUSC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg08499158 chr17:42289980 UBTF -0.47 -8.04 -0.4 1.61e-14 Total body bone mineral density; LUSC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 6.31 0.33 8.82e-10 Electroencephalogram traits; LUSC cis rs7246967 0.673 rs59567211 chr19:22829882 G/A cg23217946 chr19:22817039 ZNF492 0.47 6.55 0.34 2.19e-10 Bronchopulmonary dysplasia; LUSC cis rs8077889 0.956 rs58242860 chr17:41847300 T/C cg26893861 chr17:41843967 DUSP3 0.88 13.37 0.59 6.01e-33 Triglycerides; LUSC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg09034736 chr1:150693464 HORMAD1 0.41 5.72 0.3 2.38e-8 Melanoma; LUSC cis rs7809950 0.768 rs62482493 chr7:106951579 T/C cg23024343 chr7:107201750 COG5 -0.68 -9.57 -0.46 2.45e-19 Coronary artery disease; LUSC cis rs950169 0.960 rs35159785 chr15:84804014 G/A cg17507749 chr15:85114479 UBE2QP1 0.69 8.63 0.43 2.5e-16 Schizophrenia; LUSC cis rs7945718 0.781 rs10741604 chr11:12840940 C/A cg25843174 chr11:12811716 TEAD1 0.32 7.35 0.37 1.49e-12 Educational attainment (years of education); LUSC cis rs2219968 1.000 rs12056577 chr8:78961915 A/C cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg20476274 chr7:133979776 SLC35B4 0.8 14.12 0.61 8.01e-36 Mean platelet volume; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg02675527 chr2:114030824 PAX8;LOC440839 0.37 5.75 0.3 1.99e-8 Lymphocyte counts; LUSC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg07701084 chr6:150067640 NUP43 0.44 6.74 0.35 7.05e-11 Testicular germ cell tumor; LUSC cis rs6964587 1.000 rs11772102 chr7:91558326 A/T cg22709100 chr7:91322751 NA -0.39 -5.83 -0.3 1.32e-8 Breast cancer; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.79e-30 Prudent dietary pattern; LUSC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg06008330 chr7:65541103 ASL -0.38 -5.76 -0.3 1.94e-8 Aortic root size; LUSC cis rs1568889 0.838 rs10835283 chr11:28214985 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 12.8 0.57 8.38e-31 Bipolar disorder; LUSC cis rs6543140 0.964 rs1523205 chr2:103070176 G/T cg09003973 chr2:102972529 NA 0.54 6.87 0.35 3.08e-11 Blood protein levels; LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg00149659 chr3:10157352 C3orf10 0.91 12.66 0.57 2.94e-30 Alzheimer's disease; LUSC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg20406979 chr6:167373233 NA -0.26 -6.29 -0.33 9.8e-10 Crohn's disease; LUSC cis rs11039100 0.607 rs35916605 chr11:5782844 T/G cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs909341 0.909 rs1048665 chr20:62331989 T/G cg09650180 chr20:62225654 GMEB2 -0.46 -6.01 -0.31 4.87e-9 Atopic dermatitis; LUSC cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs68170813 0.652 rs763386 chr7:107196723 T/C cg02696742 chr7:106810147 HBP1 -0.64 -8.59 -0.43 3.37e-16 Coronary artery disease; LUSC cis rs7264396 0.635 rs6121102 chr20:34544274 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.81 -0.43 6.75e-17 Total cholesterol levels; LUSC cis rs4494114 1.000 rs12037982 chr1:39358600 G/A cg25970120 chr1:39325951 RRAGC -0.39 -6.2 -0.32 1.7e-9 Blood protein levels; LUSC cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg05340658 chr4:99064831 C4orf37 0.68 11.57 0.53 2.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs12421382 0.636 rs60266280 chr11:109387766 A/C cg11473876 chr11:109292803 C11orf87 0.41 6.87 0.35 3.13e-11 Schizophrenia; LUSC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg12516959 chr21:47718080 NA 0.39 6.32 0.33 8.44e-10 Testicular germ cell tumor; LUSC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs2282802 0.685 rs6580473 chr5:139646962 C/T cg26211634 chr5:139558579 C5orf32 -0.36 -6.51 -0.34 2.74e-10 Intelligence (multi-trait analysis); LUSC cis rs1023500 0.573 rs13057094 chr22:42470317 T/C cg15557168 chr22:42548783 NA -0.41 -6.07 -0.32 3.43e-9 Schizophrenia; LUSC cis rs6700896 0.500 rs72641129 chr1:66075123 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 6.99e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.23e-10 Extrinsic epigenetic age acceleration; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17157516 chr1:35332203 DLGAP3 0.46 6.68 0.34 9.8e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg17420585 chr12:42539391 GXYLT1 -0.36 -7.14 -0.36 5.99e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs656319 0.580 rs13252589 chr8:10005526 A/G cg21775007 chr8:11205619 TDH -0.44 -6.1 -0.32 2.88e-9 Myopia (pathological); LUSC cis rs4654899 0.758 rs6426667 chr1:21396216 C/A cg01072550 chr1:21505969 NA -0.5 -7.64 -0.39 2.31e-13 Superior frontal gyrus grey matter volume; LUSC cis rs7215564 0.908 rs7501544 chr17:78660946 T/A cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs8014204 0.781 rs10143492 chr14:75212114 G/C cg06637938 chr14:75390232 RPS6KL1 0.56 8.74 0.43 1.16e-16 Caffeine consumption; LUSC cis rs8060686 0.516 rs8059575 chr16:68272635 C/G cg05110241 chr16:68378359 PRMT7 -0.53 -6.55 -0.34 2.19e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs354225 0.544 rs10170355 chr2:54808322 G/A cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs5758659 1.000 rs134900 chr22:42683343 C/G cg05082376 chr22:42548792 NA -0.4 -6.74 -0.35 6.87e-11 Cognitive function; LUSC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg11764359 chr7:65958608 NA 0.63 9.51 0.46 3.92e-19 Aortic root size; LUSC trans rs61931739 0.817 rs10772143 chr12:34230651 T/G cg13010199 chr12:38710504 ALG10B 0.38 6.09 0.32 3.17e-9 Morning vs. evening chronotype; LUSC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg25204440 chr1:209979598 IRF6 0.49 5.73 0.3 2.29e-8 Cleft lip with or without cleft palate; LUSC cis rs4727027 0.704 rs12704073 chr7:148905067 G/A cg23158103 chr7:148848205 ZNF398 -0.48 -8.03 -0.4 1.63e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2976388 0.967 rs2976395 chr8:143763750 G/A cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs1983170 0.736 rs11164909 chr1:92002506 T/C cg25838465 chr1:92012736 NA 0.47 5.77 0.3 1.77e-8 Eosinophil percentage of white cells; LUSC cis rs1572072 0.686 rs4770462 chr13:24129056 C/G cg24350296 chr13:24144486 TNFRSF19 -0.31 -5.91 -0.31 8.64e-9 Nasopharyngeal carcinoma; LUSC cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs7824557 0.547 rs2736287 chr8:11228006 G/A cg21293242 chr8:11204541 TDH -0.31 -5.93 -0.31 7.59e-9 Retinal vascular caliber; LUSC cis rs9309473 0.519 rs13009035 chr2:73845709 T/C cg20560298 chr2:73613845 ALMS1 0.46 7.08 0.36 8.43e-12 Metabolite levels; LUSC trans rs10802346 0.545 rs2362253 chr1:246371676 G/A cg13514129 chr1:39547527 MACF1 0.71 11.79 0.54 4.48e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs2290159 0.800 rs55762590 chr3:12689451 C/T cg23032965 chr3:12705835 RAF1 0.74 9.1 0.45 8.33e-18 Cholesterol, total; LUSC cis rs6076065 1.000 rs6083105 chr20:23368475 C/A cg11657817 chr20:23433608 CST11 0.44 8.66 0.43 2.12e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs4268898 1.000 rs1203 chr2:24443330 A/G cg06627628 chr2:24431161 ITSN2 0.61 9.09 0.45 9.2e-18 Asthma; LUSC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg05855489 chr10:104503620 C10orf26 -0.7 -10.22 -0.49 1.59e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs8072100 0.846 rs6503796 chr17:45765249 T/C cg04995722 chr7:26192034 NFE2L3 -0.41 -6.48 -0.33 3.31e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9858542 0.537 rs2304442 chr3:49322027 A/T cg07274523 chr3:49395745 GPX1 -0.47 -5.93 -0.31 7.66e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg19346786 chr7:2764209 NA -0.45 -7.56 -0.38 3.99e-13 Height; LUSC cis rs3772130 0.564 rs28760466 chr3:121601510 A/G cg11130432 chr3:121712080 ILDR1 0.37 5.87 0.31 1.04e-8 Cognitive performance; LUSC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg19230755 chr7:65878503 NA -0.41 -5.74 -0.3 2.17e-8 Aortic root size; LUSC cis rs4285028 0.747 rs10049060 chr3:121358448 C/T cg11130432 chr3:121712080 ILDR1 0.57 8.55 0.42 4.41e-16 Multiple sclerosis; LUSC cis rs11758351 1.000 rs80259160 chr6:26190199 C/T cg01420254 chr6:26195488 NA 0.7 7.46 0.38 7.56e-13 Gout;Renal underexcretion gout; LUSC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg06022373 chr22:39101656 GTPBP1 0.8 12.53 0.57 8.45e-30 Menopause (age at onset); LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg03579872 chr1:53393473 SCP2 -0.39 -5.78 -0.3 1.74e-8 Monocyte count; LUSC cis rs13394619 0.875 rs9287734 chr2:11724475 A/G cg07314298 chr2:11723111 GREB1 -0.58 -10.46 -0.5 2.37e-22 Endometriosis; LUSC cis rs4363385 0.747 rs10399896 chr1:152975083 T/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.67 -0.39 1.85e-13 Inflammatory skin disease; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg08736216 chr1:53307985 ZYG11A -0.29 -5.76 -0.3 1.92e-8 Monocyte count; LUSC cis rs6942756 1.000 rs7803052 chr7:128959427 A/G cg02491457 chr7:128862824 NA -0.48 -6.51 -0.34 2.75e-10 White matter hyperintensity burden; LUSC cis rs2227564 0.620 rs3911887 chr10:75548026 A/G cg23231163 chr10:75533350 FUT11 -0.46 -6.79 -0.35 5.08e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9303401 0.573 rs67378767 chr17:57194237 G/T cg25039879 chr17:56429692 SUPT4H1 0.67 8.76 0.43 1.01e-16 Cognitive test performance; LUSC cis rs561341 0.609 rs11658984 chr17:30186612 C/T cg00745463 chr17:30367425 LRRC37B 0.63 7.58 0.38 3.37e-13 Hip circumference adjusted for BMI; LUSC cis rs1691799 0.799 rs10784525 chr12:66772766 G/A cg16791601 chr12:66731901 HELB -0.73 -12.47 -0.56 1.45e-29 White blood cell count (basophil); LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg27588902 chr6:42928151 GNMT -0.3 -6.65 -0.34 1.17e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg24110177 chr3:50126178 RBM5 -0.63 -10.82 -0.51 1.41e-23 Body mass index; LUSC cis rs1801251 1.000 rs6717841 chr2:233590255 C/T cg25237894 chr2:233734115 C2orf82 0.35 6.51 0.34 2.83e-10 Coronary artery disease; LUSC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg08847533 chr14:75593920 NEK9 -0.81 -13.83 -0.6 1.08e-34 Height; LUSC cis rs4343996 0.837 rs10215256 chr7:3484884 T/C cg21248987 chr7:3385318 SDK1 0.36 6.11 0.32 2.84e-9 Motion sickness; LUSC cis rs4766566 0.651 rs933307 chr12:111735537 A/C cg10833066 chr12:111807467 FAM109A -0.54 -9.98 -0.48 1.05e-20 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg02018176 chr4:1364513 KIAA1530 0.53 9.3 0.45 1.84e-18 Longevity; LUSC cis rs7799006 0.606 rs4721527 chr7:2306655 G/A cg12823233 chr7:2316876 SNX8 -0.45 -7.54 -0.38 4.38e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg16325326 chr1:53192061 ZYG11B -1.0 -20.61 -0.75 1.82e-61 Monocyte count; LUSC trans rs12310956 0.510 rs6488178 chr12:33885251 C/G cg26384229 chr12:38710491 ALG10B 0.56 8.69 0.43 1.66e-16 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.71 12.0 0.55 7.98e-28 Prudent dietary pattern; LUSC cis rs1577917 0.771 rs2842613 chr6:86305702 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.6 0.43 3.2e-16 Response to antipsychotic treatment; LUSC cis rs72781680 0.752 rs55806536 chr2:23912697 A/G cg20701182 chr2:24300061 SF3B14 0.75 7.34 0.37 1.61e-12 Lymphocyte counts; LUSC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg17971929 chr21:40555470 PSMG1 0.78 13.24 0.59 1.8e-32 Cognitive function; LUSC cis rs35146811 0.844 rs4424195 chr7:99642745 A/G cg13334819 chr7:99746414 C7orf59 -0.42 -5.68 -0.3 2.91e-8 Coronary artery disease; LUSC cis rs2839186 0.814 rs2276257 chr21:47711229 A/G cg13126279 chr21:47581558 C21orf56 -0.43 -6.18 -0.32 1.82e-9 Testicular germ cell tumor; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg27284194 chr4:1044797 NA 0.34 5.68 0.3 2.86e-8 Obesity-related traits; LUSC cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg12698349 chr2:225449008 CUL3 0.72 9.13 0.45 6.54e-18 IgE levels in asthmatics (D.p. specific); LUSC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg21028142 chr17:79581711 NPLOC4 0.33 7.88 0.4 4.82e-14 Eye color traits; LUSC cis rs422421 0.951 rs31777 chr5:176523562 C/A cg00618323 chr5:176515533 FGFR4 0.38 6.07 0.32 3.52e-9 Height; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.03e-17 Prudent dietary pattern; LUSC cis rs273573 0.925 rs163883 chr11:30947248 A/G cg14844989 chr11:31128820 NA 0.38 6.0 0.31 5.07e-9 Total body bone mineral density; LUSC cis rs11785400 1.000 rs4736365 chr8:143742197 A/G cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC cis rs500891 0.533 rs10943931 chr6:84146803 T/C cg08257003 chr6:84140564 ME1 0.36 8.73 0.43 1.27e-16 Platelet-derived growth factor BB levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03784882 chr7:2758244 NA -0.39 -6.03 -0.31 4.33e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 8.06 0.4 1.38e-14 Axial length; LUSC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg18230493 chr5:56204884 C5orf35 -0.88 -13.39 -0.59 4.99e-33 Initial pursuit acceleration; LUSC cis rs12701220 0.553 rs34062359 chr7:1139076 C/T cg26769984 chr7:1090371 C7orf50 0.58 7.62 0.38 2.6e-13 Bronchopulmonary dysplasia; LUSC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg22618164 chr12:122356400 WDR66 0.63 9.57 0.46 2.42e-19 Mean platelet volume; LUSC cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg24812749 chr6:127587940 RNF146 0.92 13.82 0.6 1.14e-34 Breast cancer; LUSC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg27398817 chr8:82754497 SNX16 0.47 6.3 0.33 9.56e-10 Diastolic blood pressure; LUSC cis rs12980942 0.810 rs8103839 chr19:41781493 C/G cg25627403 chr19:41769009 HNRNPUL1 0.59 6.44 0.33 4.28e-10 Coronary artery disease; LUSC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg01879757 chr17:41196368 BRCA1 -0.47 -7.28 -0.37 2.36e-12 Menopause (age at onset); LUSC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg22800045 chr5:56110881 MAP3K1 0.8 10.0 0.48 9.12e-21 Initial pursuit acceleration; LUSC cis rs7267979 0.808 rs84816 chr20:25459919 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 19.66 0.73 1.04e-57 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg21880101 chr17:80066754 CCDC57 -0.32 -5.93 -0.31 7.63e-9 Life satisfaction; LUSC cis rs2219968 0.961 rs35174414 chr8:78977693 C/T cg00738934 chr8:78996279 NA 0.35 6.33 0.33 7.89e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.36 0.69 1.51e-48 Chronic sinus infection; LUSC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.8 -0.39 7.95e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs877282 0.898 rs71489279 chr10:760510 T/C cg13042288 chr15:90349979 ANPEP -0.44 -6.31 -0.33 8.93e-10 Uric acid levels; LUSC cis rs6430585 0.591 rs12477421 chr2:136433740 A/G cg07169764 chr2:136633963 MCM6 1.08 14.51 0.62 2.58e-37 Corneal structure; LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg11843238 chr5:131593191 PDLIM4 -0.38 -6.18 -0.32 1.87e-9 Breast cancer; LUSC cis rs7582180 0.764 rs1946799 chr2:100921136 C/A cg12002119 chr2:101014098 CHST10 0.36 6.09 0.32 3.15e-9 Intelligence (multi-trait analysis); LUSC cis rs1577917 1.000 rs7747824 chr6:86647106 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg00677455 chr12:58241039 CTDSP2 0.73 11.33 0.53 2.08e-25 Multiple sclerosis; LUSC cis rs2692947 0.770 rs4527246 chr2:96560303 T/C cg22654517 chr2:96458247 NA 0.38 7.62 0.38 2.72e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg27661571 chr11:113659931 NA -0.67 -7.74 -0.39 1.16e-13 Hip circumference adjusted for BMI; LUSC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg20701182 chr2:24300061 SF3B14 0.9 11.53 0.53 4.11e-26 Lymphocyte counts; LUSC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg06484146 chr7:12443880 VWDE -0.69 -7.35 -0.37 1.53e-12 Coronary artery disease; LUSC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg24296786 chr1:45957014 TESK2 0.47 6.91 0.35 2.51e-11 High light scatter reticulocyte count; LUSC cis rs644799 0.710 rs10765771 chr11:95521044 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.85 14.15 0.61 6.21e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2797160 1.000 rs2797158 chr6:126009398 G/A cg05901451 chr6:126070800 HEY2 0.57 8.53 0.42 5.32e-16 Endometrial cancer; LUSC cis rs2197308 0.740 rs10880619 chr12:37922720 T/C cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs8114671 0.562 rs8117491 chr20:33510120 T/C cg24642439 chr20:33292090 TP53INP2 0.45 6.48 0.33 3.38e-10 Height; LUSC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg05738196 chr6:26577821 NA -0.48 -7.12 -0.36 6.61e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg01119278 chr6:110721349 DDO -0.48 -8.71 -0.43 1.45e-16 Platelet distribution width; LUSC trans rs3942852 0.568 rs10769313 chr11:48097466 A/G cg15704280 chr7:45808275 SEPT13 -0.62 -8.13 -0.41 8.56e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs2953174 0.507 rs2953172 chr2:241525316 C/T cg07929629 chr2:241523174 NA 0.55 8.82 0.43 6.44e-17 Bipolar disorder; LUSC trans rs1941687 0.831 rs12954615 chr18:31384449 G/T cg27147174 chr7:100797783 AP1S1 -0.45 -6.94 -0.36 2.05e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs61774743 0.557 rs4660192 chr1:41842350 C/T cg01193554 chr1:41846683 NA -0.29 -6.18 -0.32 1.86e-9 Intelligence (multi-trait analysis); LUSC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg04248312 chr19:17393744 ANKLE1 -1.02 -16.53 -0.67 2.81e-45 Systemic lupus erythematosus; LUSC cis rs7674212 0.541 rs2720448 chr4:104030589 C/T cg16532752 chr4:104119610 CENPE -0.49 -6.82 -0.35 4.2e-11 Type 2 diabetes; LUSC cis rs17125944 0.506 rs7151491 chr14:53313711 C/G cg00686598 chr14:53173677 PSMC6 -0.62 -5.82 -0.3 1.36e-8 Alzheimer's disease (late onset); LUSC cis rs6977660 0.598 rs10239147 chr7:19787459 T/C cg05791153 chr7:19748676 TWISTNB 0.75 7.9 0.4 3.96e-14 Thyroid stimulating hormone; LUSC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg04398451 chr17:18023971 MYO15A 0.5 7.97 0.4 2.45e-14 Total body bone mineral density; LUSC cis rs1904096 0.506 rs4693378 chr4:95168552 A/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.36 -0.42 1.73e-15 Type 2 diabetes; LUSC cis rs2617583 0.530 rs905201 chr5:1457986 C/T cg13982541 chr5:1466431 LPCAT1 0.41 5.92 0.31 7.84e-9 Breast cancer; LUSC cis rs877282 0.853 rs7092805 chr10:756246 G/A cg17470449 chr10:769945 NA 0.52 7.14 0.36 6e-12 Uric acid levels; LUSC cis rs2625529 0.652 rs8030815 chr15:72403001 T/C cg16672083 chr15:72433130 SENP8 0.48 8.08 0.4 1.21e-14 Red blood cell count; LUSC cis rs34779708 0.931 rs11010082 chr10:35351155 A/G cg03585969 chr10:35415529 CREM 0.6 8.84 0.44 5.75e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1153858 1.000 rs2467858 chr15:45711492 A/G cg26924012 chr15:45694286 SPATA5L1 1.1 19.11 0.72 1.62e-55 Homoarginine levels; LUSC cis rs1348850 0.874 rs13013752 chr2:178456862 A/G cg22681709 chr2:178499509 PDE11A -0.47 -8.36 -0.42 1.68e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2625529 0.586 rs7175197 chr15:72461648 G/A cg16672083 chr15:72433130 SENP8 0.48 7.92 0.4 3.5e-14 Red blood cell count; LUSC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg15744005 chr10:104629667 AS3MT -0.28 -6.0 -0.31 5.09e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.38 0.46 1.03e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.58 0.38 3.35e-13 Parkinson's disease; LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg08088566 chr11:430123 ANO9 0.67 7.39 0.37 1.22e-12 Body mass index; LUSC cis rs9814567 0.752 rs4955542 chr3:134328740 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs708547 0.874 rs73242624 chr4:57847420 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.64 8.42 0.42 1.09e-15 Response to bleomycin (chromatid breaks); LUSC cis rs250677 0.917 rs36066 chr5:148419771 A/G cg12140854 chr5:148520817 ABLIM3 -0.39 -6.15 -0.32 2.27e-9 Breast cancer; LUSC cis rs7582180 0.614 rs2241809 chr2:101014363 C/T cg08017756 chr2:100939284 LONRF2 -0.48 -8.9 -0.44 3.73e-17 Intelligence (multi-trait analysis); LUSC cis rs1670533 1.000 rs11731320 chr4:1057916 T/A cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs778371 0.788 rs4973569 chr2:233767037 A/G cg08000102 chr2:233561755 GIGYF2 -0.63 -8.39 -0.42 1.43e-15 Schizophrenia; LUSC cis rs7202877 0.610 rs11149814 chr16:75332981 T/C cg03315344 chr16:75512273 CHST6 0.4 5.84 0.3 1.23e-8 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9916302 0.706 rs11078894 chr17:37396805 C/G cg07936489 chr17:37558343 FBXL20 -0.81 -10.51 -0.5 1.6400000000000001e-22 Glomerular filtration rate (creatinine); LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg02018176 chr4:1364513 KIAA1530 0.71 12.62 0.57 3.91e-30 Longevity; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg16558319 chr12:97301661 NEDD1 0.33 6.04 0.31 4.14e-9 Metabolite levels (Pyroglutamine); LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.27 0.56 8.01e-29 Prudent dietary pattern; LUSC cis rs941873 0.868 rs7332 chr10:81114060 G/A cg09469691 chr10:81107165 PPIF 0.65 9.72 0.47 7.73e-20 Height; LUSC cis rs782590 0.935 rs2586954 chr2:55892261 A/C cg03859395 chr2:55845619 SMEK2 0.91 16.85 0.68 1.56e-46 Metabolic syndrome; LUSC cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.42 0.85 9.58e-95 Chronic sinus infection; LUSC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.92 -0.44 3.04e-17 Axial length; LUSC cis rs12458462 0.892 rs35928863 chr18:77438956 A/G cg20476159 chr18:77451067 CTDP1 -0.32 -5.8 -0.3 1.58e-8 Monocyte count; LUSC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg06212747 chr3:49208901 KLHDC8B 0.45 6.06 0.31 3.63e-9 Parkinson's disease; LUSC cis rs1348850 0.750 rs55792594 chr2:178496468 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.78 0.3 1.67e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg02569458 chr12:86230093 RASSF9 0.6 10.08 0.48 4.97e-21 Major depressive disorder; LUSC cis rs1577917 1.000 rs12201880 chr6:86627007 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC trans rs11098499 0.818 rs12498599 chr4:120468503 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.83 0.35 3.91e-11 Corneal astigmatism; LUSC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.58e-15 Developmental language disorder (linguistic errors); LUSC trans rs539514 0.690 rs528783 chr13:76319460 T/C cg05302441 chr11:125157402 PKNOX2 0.27 6.25 0.32 1.25e-9 Type 1 diabetes; LUSC cis rs17685 0.712 rs6953342 chr7:75776753 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.54 -8.23 -0.41 4.13e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7215564 0.908 rs56078934 chr17:78658849 A/C cg09596252 chr17:78655493 RPTOR 0.55 6.04 0.31 4.18e-9 Myopia (pathological); LUSC cis rs6964587 1.000 rs7811564 chr7:91663364 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.44e-8 Breast cancer; LUSC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg23172400 chr8:95962367 TP53INP1 -0.38 -7.71 -0.39 1.43e-13 Type 2 diabetes; LUSC cis rs11625487 0.957 rs28820314 chr14:77963272 A/C cg16049707 chr14:77965284 ISM2 -0.55 -7.68 -0.39 1.84e-13 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs6665290 0.904 rs11578103 chr1:227189642 C/A cg10327440 chr1:227177885 CDC42BPA -1.22 -39.14 -0.91 8.08e-127 Myeloid white cell count; LUSC cis rs7084921 0.608 rs7474634 chr10:101863410 A/C cg11888571 chr10:102027403 CWF19L1 0.45 6.3 0.33 9.47e-10 Bone mineral density; LUSC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg21984481 chr17:79567631 NPLOC4 -0.57 -10.9 -0.51 7.17e-24 Eye color traits; LUSC cis rs708547 0.874 rs1718869 chr4:57880232 A/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.63 -0.34 1.39e-10 Response to bleomycin (chromatid breaks); LUSC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg16346588 chr10:242978 ZMYND11 0.4 5.72 0.3 2.38e-8 Psychosis in Alzheimer's disease; LUSC cis rs7829975 0.514 rs2920991 chr8:8259117 T/A cg08975724 chr8:8085496 FLJ10661 0.51 7.93 0.4 3.27e-14 Mood instability; LUSC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg04398451 chr17:18023971 MYO15A -0.46 -7.35 -0.37 1.59e-12 Total body bone mineral density; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg06600287 chr1:53387719 ECHDC2 -0.3 -6.18 -0.32 1.91e-9 Monocyte count; LUSC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.79 0.39 8.44e-14 Parkinson's disease; LUSC cis rs600231 0.508 rs34582634 chr11:65220206 G/A cg17120908 chr11:65337727 SSSCA1 -0.64 -9.34 -0.46 1.41e-18 Bone mineral density; LUSC trans rs7824557 0.527 rs2736296 chr8:11234844 G/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.37 -0.33 6.31e-10 Retinal vascular caliber; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg11728497 chr12:12871887 CDKN1B 0.54 6.31 0.33 9.03e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg12560992 chr17:57184187 TRIM37 -0.78 -13.61 -0.6 7.3e-34 Intelligence (multi-trait analysis); LUSC cis rs7296418 0.961 rs10773921 chr12:123541606 C/T cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.4 -0.42 1.32e-15 Platelet count; LUSC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg26116260 chr4:7069785 GRPEL1 1.12 17.82 0.7 2.17e-50 Monocyte percentage of white cells; LUSC cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg06618935 chr21:46677482 NA -0.37 -7.2 -0.37 4.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs243505 0.667 rs10249029 chr7:148576042 C/T cg09806900 chr7:148480153 CUL1 0.53 7.44 0.38 8.44e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs921968 0.643 rs3770218 chr2:219525335 C/T cg02176678 chr2:219576539 TTLL4 0.59 10.61 0.5 7.4e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg08109568 chr15:31115862 NA 0.73 11.38 0.53 1.39e-25 Huntington's disease progression; LUSC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.64 0.47 1.49e-19 Bipolar disorder; LUSC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.28 -0.33 1.04e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02047577 chr20:62587702 UCKL1AS;UCKL1 -0.45 -6.54 -0.34 2.27e-10 Electrocardiographic conduction measures; LUSC cis rs12421382 0.659 rs12420684 chr11:109391788 T/C cg11473876 chr11:109292803 C11orf87 0.41 6.76 0.35 6.24e-11 Schizophrenia; LUSC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg23978390 chr7:1156363 C7orf50 0.46 5.98 0.31 5.59e-9 Bronchopulmonary dysplasia; LUSC cis rs75920871 0.702 rs59511712 chr11:116945762 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.52 -5.92 -0.31 8.02e-9 Subjective well-being; LUSC cis rs1729951 0.546 rs835634 chr3:136676303 C/T cg12473912 chr3:136751656 NA 0.38 6.68 0.34 9.74e-11 Neuroticism; LUSC trans rs2562456 0.793 rs627522 chr19:21495804 C/T cg00806126 chr19:22604979 ZNF98 -0.39 -6.28 -0.32 1.07e-9 Pain; LUSC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg00310523 chr12:86230176 RASSF9 -0.42 -7.84 -0.39 6.02e-14 Major depressive disorder; LUSC cis rs9815354 0.812 rs73073337 chr3:41837497 T/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs17539620 0.624 rs62432746 chr6:154838986 A/G cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC cis rs17685 0.753 rs7788763 chr7:75651665 T/C cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.79 0.39 8.75e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg20849893 chr7:64541193 NA 0.5 7.11 0.36 7.26e-12 Calcium levels; LUSC cis rs6598955 0.543 rs57564009 chr1:26557618 A/T cg04990556 chr1:26633338 UBXN11 0.88 11.67 0.54 1.3e-26 Obesity-related traits; LUSC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg15839431 chr19:19639596 YJEFN3 -0.42 -5.93 -0.31 7.59e-9 Tonsillectomy; LUSC trans rs1508086 0.935 rs7829576 chr8:57826398 A/G cg01310875 chr8:27938995 C8orf80 0.28 6.2 0.32 1.67e-9 Hand grip strength; LUSC trans rs62238980 0.614 rs4821005 chr22:32369804 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs6496667 0.683 rs2589973 chr15:90892293 C/T cg22089800 chr15:90895588 ZNF774 0.58 8.26 0.41 3.45e-15 Rheumatoid arthritis; LUSC trans rs236907 0.859 rs12753043 chr1:171761821 G/A cg13482142 chr2:234261155 NA 0.48 6.05 0.31 3.8e-9 Mean platelet volume; LUSC cis rs654351 0.572 rs813274 chr6:10387731 C/T cg04978078 chr6:10383147 NA -0.31 -5.77 -0.3 1.82e-8 Squamous cell lung carcinoma; LUSC trans rs57221529 0.766 rs72703064 chr5:587825 T/C cg25482853 chr8:67687455 SGK3 1.18 16.97 0.68 5.1e-47 Lung disease severity in cystic fibrosis; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg07667813 chr19:7985168 SNAPC2 0.37 6.43 0.33 4.39e-10 Calcium levels; LUSC cis rs62400317 0.762 rs12208332 chr6:44903221 C/T cg20913747 chr6:44695427 NA -0.47 -7.31 -0.37 1.96e-12 Total body bone mineral density; LUSC cis rs9309473 0.500 rs6757996 chr2:73772251 G/A cg20560298 chr2:73613845 ALMS1 -0.5 -7.76 -0.39 1.05e-13 Metabolite levels; LUSC cis rs7833986 0.501 rs72653990 chr8:57037115 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.15 0.55 2.14e-28 Height; LUSC cis rs10266483 0.705 rs660228 chr7:63756245 T/C cg24201672 chr7:64023550 ZNF680 -0.45 -5.75 -0.3 1.97e-8 Response to statin therapy; LUSC cis rs8062405 1.000 rs56358680 chr16:28843118 A/G cg09754948 chr16:28834200 ATXN2L 0.41 6.13 0.32 2.5e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9807989 0.507 rs13021177 chr2:103056493 A/G cg03938978 chr2:103052716 IL18RAP 0.36 6.93 0.35 2.2e-11 Asthma; LUSC cis rs34779708 0.931 rs13376801 chr10:35370443 T/C cg04310649 chr10:35416472 CREM -0.41 -6.54 -0.34 2.32e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.83 0.39 6.53e-14 Prudent dietary pattern; LUSC cis rs7119 0.635 rs867916 chr15:77882860 A/G cg27398640 chr15:77910606 LINGO1 0.36 8.45 0.42 8.95e-16 Type 2 diabetes; LUSC cis rs10876993 0.890 rs1082502 chr12:58035706 C/T cg18357645 chr12:58087776 OS9 0.51 7.68 0.39 1.74e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs11039100 0.850 rs12792985 chr11:5833742 A/G cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg26446133 chr18:72167187 CNDP2 -0.78 -10.87 -0.51 9.06e-24 Refractive error; LUSC cis rs983392 0.678 rs7108663 chr11:60028142 C/T cg24026212 chr11:59952134 MS4A6A 0.36 6.33 0.33 7.73e-10 Alzheimer's disease (late onset); LUSC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg22532475 chr10:104410764 TRIM8 -0.35 -7.53 -0.38 4.76e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6754311 0.731 rs10207652 chr2:136588478 T/A cg07169764 chr2:136633963 MCM6 -0.61 -8.02 -0.4 1.81e-14 Mosquito bite size; LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg11645453 chr3:52864694 ITIH4 0.37 8.48 0.42 7.18e-16 Bipolar disorder; LUSC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg18230493 chr5:56204884 C5orf35 0.76 12.29 0.56 6.94e-29 Initial pursuit acceleration; LUSC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg12311346 chr5:56204834 C5orf35 -0.63 -9.02 -0.44 1.47e-17 Coronary artery disease; LUSC cis rs11098499 0.866 rs11098506 chr4:120284971 A/G cg24375607 chr4:120327624 NA 0.69 10.34 0.49 6.59e-22 Corneal astigmatism; LUSC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg06634786 chr22:41940651 POLR3H 0.51 5.95 0.31 6.94e-9 Vitiligo; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg01238044 chr22:24384105 GSTT1 0.59 7.42 0.38 9.77e-13 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg00033643 chr7:134001901 SLC35B4 0.42 6.61 0.34 1.56e-10 Mean platelet volume; LUSC cis rs9788721 1.000 rs8034191 chr15:78806023 A/G cg18825076 chr15:78729989 IREB2 -0.48 -7.85 -0.39 5.75e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg25036284 chr2:26402008 FAM59B 0.77 11.38 0.53 1.46e-25 Gut microbiome composition (summer); LUSC cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg21984481 chr17:79567631 NPLOC4 -0.72 -15.08 -0.64 1.53e-39 Eye color traits; LUSC cis rs950027 0.620 rs1145077 chr15:45683795 A/C cg04036182 chr15:45458818 NA -0.36 -6.08 -0.32 3.26e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs2274273 0.684 rs2340921 chr14:55563705 A/G cg04306507 chr14:55594613 LGALS3 0.5 10.94 0.51 5.1e-24 Protein biomarker; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03576123 chr11:487126 PTDSS2 -1.05 -11.18 -0.52 7.13e-25 Body mass index; LUSC cis rs2806561 0.704 rs7532266 chr1:23551623 A/C cg19743168 chr1:23544995 NA -0.48 -9.17 -0.45 5.08e-18 Height; LUSC cis rs6542838 0.609 rs12712043 chr2:99541494 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.88 -0.35 3.01e-11 Fear of minor pain; LUSC trans rs12310956 0.527 rs10772117 chr12:33900096 C/T cg26384229 chr12:38710491 ALG10B 0.61 9.68 0.47 1.11e-19 Morning vs. evening chronotype; LUSC cis rs734999 0.545 rs6666430 chr1:2698950 G/A cg18932078 chr1:2524107 MMEL1 0.3 6.4 0.33 5.25e-10 Ulcerative colitis; LUSC cis rs4776059 0.798 rs58018557 chr15:52901284 T/C cg24008177 chr15:52972085 KIAA1370 -0.33 -5.86 -0.31 1.1e-8 Schizophrenia; LUSC cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg18876405 chr7:65276391 NA 0.56 8.78 0.43 8.71e-17 Aortic root size; LUSC trans rs895636 0.519 rs4953155 chr2:45189496 A/T cg09302903 chr17:46801314 C17orf93;PRAC 0.3 6.01 0.31 4.82e-9 Metabolite levels;Fasting plasma glucose; LUSC cis rs2236918 0.710 rs1635507 chr1:242028358 G/T cg17736920 chr1:242011382 EXO1 0.44 6.9 0.35 2.61e-11 Menopause (age at onset); LUSC cis rs4974559 0.739 rs59810282 chr4:1320968 A/G cg02980000 chr4:1222292 CTBP1 0.98 9.13 0.45 6.68e-18 Systolic blood pressure; LUSC cis rs10654220 1 rs10654220 chr12:123703422 A/AGTT cg00376283 chr12:123451042 ABCB9 0.7 7.83 0.39 6.5e-14 Platelet count; LUSC trans rs2898290 0.622 rs11250140 chr8:11346592 A/C cg15556689 chr8:8085844 FLJ10661 -0.54 -8.37 -0.42 1.6e-15 Systolic blood pressure; LUSC cis rs9875589 0.509 rs4684174 chr3:14048375 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.12 0.36 6.68e-12 Ovarian reserve; LUSC cis rs738322 0.810 rs4820325 chr22:38599978 G/A cg25457927 chr22:38595422 NA 0.48 10.04 0.48 6.43e-21 Cutaneous nevi; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18404041 chr3:52824283 ITIH1 -0.46 -8.51 -0.42 5.91e-16 Electroencephalogram traits; LUSC cis rs4988958 0.525 rs3771159 chr2:103004958 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.29e-12 Asthma (childhood onset); LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg13560548 chr3:10150139 C3orf24 0.53 7.37 0.37 1.39e-12 Alzheimer's disease; LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg19318889 chr4:1322082 MAEA 0.47 5.69 0.3 2.85e-8 Recombination rate (females); LUSC trans rs12902680 0.607 rs12440533 chr15:46585492 A/T cg04321580 chr8:143696133 ARC 0.4 6.16 0.32 2.11e-9 Neuroticism; LUSC cis rs11711311 0.784 rs13081931 chr3:113349928 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.32 0.33 8.2e-10 IgG glycosylation; LUSC cis rs6964587 1.000 rs34043009 chr7:91578447 T/C cg17063962 chr7:91808500 NA -0.58 -9.19 -0.45 4.34e-18 Breast cancer; LUSC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg09877947 chr5:131593287 PDLIM4 0.48 7.83 0.39 6.63e-14 Breast cancer; LUSC cis rs8072100 0.727 rs4794052 chr17:45769236 T/C cg19784903 chr17:45786737 TBKBP1 -0.42 -6.04 -0.31 4.11e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.19 0.64 5.47e-40 Platelet count; LUSC cis rs9527 0.590 rs7073323 chr10:104797423 A/C cg04362960 chr10:104952993 NT5C2 0.6 8.79 0.43 7.81e-17 Arsenic metabolism; LUSC cis rs9527 0.590 rs12355120 chr10:104852166 T/G cg05855489 chr10:104503620 C10orf26 0.51 7.85 0.39 5.58e-14 Arsenic metabolism; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg20887711 chr4:1340912 KIAA1530 0.44 6.61 0.34 1.48e-10 Obesity-related traits; LUSC cis rs793571 0.544 rs11638244 chr15:58907151 A/T cg05156742 chr15:59063176 FAM63B 0.54 8.2 0.41 5.1e-15 Schizophrenia; LUSC cis rs17604090 1.000 rs17604090 chr7:29691438 C/T cg19413766 chr7:29689036 LOC646762 -0.58 -6.81 -0.35 4.46e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs3820068 0.581 rs12385690 chr1:15932932 A/T cg13390004 chr1:15929781 NA 0.45 7.78 0.39 9.35e-14 Systolic blood pressure; LUSC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.2 0.32 1.69e-9 Multiple sclerosis; LUSC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.78 0.35 5.5e-11 Platelet count; LUSC cis rs8062405 0.754 rs149299 chr16:28485141 T/C cg16576597 chr16:28551801 NUPR1 0.3 6.0 0.31 5.12e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg06238570 chr21:40685208 BRWD1 -0.56 -8.7 -0.43 1.59e-16 Menarche (age at onset); LUSC cis rs10191773 0.535 rs11685514 chr2:113100014 C/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.83 9.26 0.45 2.58e-18 Yeast infection; LUSC cis rs1499972 0.941 rs1456182 chr3:117659680 C/T cg07612923 chr3:117604196 NA 0.64 5.75 0.3 1.97e-8 Schizophrenia; LUSC trans rs8072100 0.656 rs2610367 chr17:45569815 A/G cg04995722 chr7:26192034 NFE2L3 -0.43 -6.74 -0.35 7.14e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11864453 0.928 rs3213420 chr16:72042433 C/T cg01557791 chr16:72042693 DHODH -0.58 -8.57 -0.42 3.84e-16 Fibrinogen levels; LUSC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12579753 0.879 rs11115002 chr12:82153090 C/T cg07988820 chr12:82153109 PPFIA2 -0.45 -6.47 -0.33 3.42e-10 Resting heart rate; LUSC cis rs2153904 0.793 rs12118655 chr1:205663478 A/G cg23034840 chr1:205782522 SLC41A1 -0.66 -6.98 -0.36 1.64e-11 Prostate-specific antigen levels; LUSC cis rs7428 0.527 rs4832164 chr2:85546932 A/C cg24342717 chr2:85555507 TGOLN2 -0.74 -12.31 -0.56 5.74e-29 Ear protrusion; LUSC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.85 -0.35 3.53e-11 Lung cancer; LUSC cis rs6076065 0.723 rs2424546 chr20:23391751 G/T cg11657817 chr20:23433608 CST11 0.42 7.97 0.4 2.62e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs9326248 0.581 rs11216242 chr11:116901549 G/A cg11861562 chr11:117069780 TAGLN 0.32 6.2 0.32 1.64e-9 Blood protein levels; LUSC cis rs4243830 0.850 rs13513 chr1:6585804 C/T cg05709478 chr1:6581295 PLEKHG5 -0.56 -6.72 -0.35 7.9e-11 Body mass index; LUSC cis rs13064411 0.660 rs1872747 chr3:113175785 T/A cg18753928 chr3:113234510 CCDC52 -0.52 -7.84 -0.39 6.31e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC trans rs17685 0.753 rs1637045 chr7:75703895 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.72 0.73 5.93e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs149163995 1 rs149163995 chr2:203777226 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.38 0.42 1.49e-15 Migraine; LUSC cis rs10504073 0.647 rs62507245 chr8:50006939 A/T cg00325661 chr8:49890786 NA 0.62 9.96 0.48 1.27e-20 Blood metabolite ratios; LUSC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg15445000 chr17:37608096 MED1 -0.41 -6.97 -0.36 1.65e-11 Glomerular filtration rate (creatinine); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01722185 chr2:20550205 NA -0.39 -5.97 -0.31 5.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg03806693 chr22:41940476 POLR3H 0.98 14.25 0.61 2.56e-36 Vitiligo; LUSC trans rs56114371 0.777 rs200482 chr6:27773904 G/A cg06606381 chr12:133084897 FBRSL1 -0.71 -7.15 -0.36 5.34e-12 Breast cancer; LUSC cis rs6733011 0.578 rs10172158 chr2:99509605 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -5.88 -0.31 9.78e-9 Bipolar disorder; LUSC cis rs3126085 0.935 rs12144058 chr1:152170216 C/T cg26876637 chr1:152193138 HRNR 0.47 6.61 0.34 1.48e-10 Atopic dermatitis; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.64 0.39 2.27e-13 Prudent dietary pattern; LUSC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg11861562 chr11:117069780 TAGLN 0.45 8.25 0.41 3.7e-15 Blood protein levels; LUSC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg24675056 chr1:15929824 NA 0.45 7.78 0.39 9.02e-14 Systolic blood pressure; LUSC cis rs7903847 0.642 rs1537646 chr10:99149922 T/C cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.66e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs61931739 0.500 rs7965679 chr12:34542494 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Bladder cancer; LUSC cis rs11098499 0.955 rs4145951 chr4:120155817 A/G cg24375607 chr4:120327624 NA 0.75 11.42 0.53 9.94e-26 Corneal astigmatism; LUSC cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.45 -6.71 -0.34 8.14e-11 Schizophrenia; LUSC cis rs1538970 0.961 rs7543428 chr1:45839643 A/G cg05343316 chr1:45956843 TESK2 0.59 8.17 0.41 6.24e-15 Platelet count; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.3 0.45 1.9e-18 Prudent dietary pattern; LUSC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg15147215 chr3:52552868 STAB1 -0.29 -5.76 -0.3 1.93e-8 Electroencephalogram traits; LUSC cis rs7511006 0.893 rs760743 chr22:50647375 C/T cg07895657 chr22:50616420 PANX2 -0.36 -6.18 -0.32 1.9e-9 Obesity-related traits; LUSC cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg24812749 chr6:127587940 RNF146 0.92 13.89 0.61 6.05e-35 Breast cancer; LUSC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg17554472 chr22:41940697 POLR3H -0.49 -5.87 -0.31 1.08e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs354225 0.597 rs10176445 chr2:54845776 G/C cg26097391 chr2:54893211 SPTBN1 0.42 6.23 0.32 1.39e-9 Schizophrenia; LUSC cis rs7829975 0.660 rs10093926 chr8:8549020 A/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.75 -0.39 1.12e-13 Mood instability; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg07395648 chr5:131743802 NA -0.44 -7.43 -0.38 8.89e-13 Blood metabolite levels; LUSC cis rs7949030 0.780 rs3017666 chr11:62404417 A/T cg22862634 chr11:62369728 EML3;MTA2 -0.49 -8.05 -0.4 1.47e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7084921 0.548 rs12776483 chr10:101828600 C/A cg02250046 chr10:101825185 CPN1 -0.34 -6.13 -0.32 2.45e-9 Bone mineral density; LUSC cis rs2979489 0.773 rs2915617 chr8:30272310 C/G cg26383811 chr8:30366931 RBPMS 0.38 5.96 0.31 6.58e-9 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs11924390 0.749 rs822363 chr3:186452991 C/G cg12454167 chr3:186435060 KNG1 0.29 7.56 0.38 3.97e-13 Adiponectin levels; LUSC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg12463550 chr7:65579703 CRCP 0.51 7.37 0.37 1.33e-12 Aortic root size; LUSC cis rs1865760 1.000 rs7757666 chr6:25902626 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.81 0.35 4.67e-11 Height; LUSC cis rs6500602 0.561 rs62039231 chr16:4519548 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.71 0.39 1.48e-13 Schizophrenia; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg18404041 chr3:52824283 ITIH1 -0.58 -11.19 -0.52 6.61e-25 Bipolar disorder; LUSC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg05872129 chr22:39784769 NA -0.61 -11.35 -0.53 1.82e-25 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.958 rs12209259 chr6:86502348 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.82 -0.35 4.34e-11 Response to antipsychotic treatment; LUSC cis rs9325144 0.723 rs11169535 chr12:39183494 C/T cg26384229 chr12:38710491 ALG10B -0.61 -9.3 -0.45 1.95e-18 Morning vs. evening chronotype; LUSC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg18252515 chr7:66147081 NA 1.24 14.21 0.61 3.56e-36 Diabetic kidney disease; LUSC trans rs7395662 0.571 rs10838947 chr11:48568693 G/T cg03929089 chr4:120376271 NA -0.44 -6.15 -0.32 2.24e-9 HDL cholesterol; LUSC cis rs7927771 0.542 rs3886262 chr11:47817010 T/G cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.88e-10 Subjective well-being; LUSC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.42 -6.37 -0.33 6.13e-10 Menarche (age at onset); LUSC cis rs6489882 0.867 rs1154970 chr12:113370427 A/C cg20102336 chr12:113376681 OAS3 -0.42 -6.37 -0.33 6.43e-10 Chronic lymphocytic leukemia; LUSC cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg06484146 chr7:12443880 VWDE -0.61 -6.07 -0.32 3.47e-9 Coronary artery disease; LUSC trans rs9473924 1.000 rs6923215 chr6:50889848 G/A cg22375689 chr19:34175036 CHST8 0.38 6.15 0.32 2.2e-9 Body mass index; LUSC trans rs1997103 0.954 rs1997099 chr7:55405540 T/C cg20935933 chr6:143382018 AIG1 0.49 7.16 0.36 5.08e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs3808502 0.647 rs7821302 chr8:11236572 T/A cg15556689 chr8:8085844 FLJ10661 -0.49 -7.54 -0.38 4.51e-13 Neuroticism; LUSC trans rs79976124 0.837 rs74327235 chr6:66648353 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 9.0 0.44 1.77e-17 Type 2 diabetes; LUSC trans rs7819412 0.623 rs7833435 chr8:10801137 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -7.9 -0.4 4.2e-14 Triglycerides; LUSC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg12963246 chr6:28129442 ZNF389 0.41 6.5 0.33 3e-10 Parkinson's disease; LUSC cis rs10779751 0.959 rs2092642 chr1:11317320 C/T cg08854313 chr1:11322531 MTOR 0.92 16.17 0.66 7.91e-44 Body mass index; LUSC cis rs2230307 0.536 rs631977 chr1:100544564 C/G cg24955406 chr1:100503596 HIAT1 0.59 6.42 0.33 4.63e-10 Carotid intima media thickness; LUSC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.15 -0.36 5.47e-12 Major depressive disorder; LUSC cis rs934734 0.967 rs702875 chr2:65614197 T/C cg08085232 chr2:65598271 SPRED2 -0.39 -6.05 -0.31 3.9e-9 Rheumatoid arthritis; LUSC trans rs7829975 0.688 rs6601703 chr8:8380224 A/G cg27411982 chr8:10470053 RP1L1 0.45 7.43 0.38 9.32e-13 Mood instability; LUSC cis rs354225 0.544 rs12713268 chr2:54808845 C/G cg01766943 chr2:54829624 SPTBN1 -0.46 -7.51 -0.38 5.34e-13 Schizophrenia; LUSC trans rs7613875 0.580 rs11709503 chr3:49991167 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.5 7.97 0.4 2.45e-14 Body mass index; LUSC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg04369109 chr6:150039330 LATS1 -0.54 -7.94 -0.4 3.06e-14 Lung cancer; LUSC cis rs886126 0.950 rs2078851 chr12:111690579 C/T cg10833066 chr12:111807467 FAM109A -0.4 -6.15 -0.32 2.16e-9 Coronary heart disease; LUSC cis rs925255 0.817 rs7606480 chr2:28632377 G/A cg01273330 chr2:28605224 NA 0.46 7.64 0.39 2.36e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs642803 0.613 rs565427 chr11:65532825 G/A cg02870584 chr11:65547924 DKFZp761E198 0.43 5.93 0.31 7.37e-9 Urate levels; LUSC trans rs459571 0.606 rs457420 chr9:136909261 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.51 7.93 0.4 3.36e-14 Platelet distribution width; LUSC cis rs7824557 0.767 rs1897950 chr8:11169551 C/A cg21775007 chr8:11205619 TDH 0.73 11.84 0.54 3.02e-27 Retinal vascular caliber; LUSC cis rs666930 0.519 rs532303 chr1:120265444 A/G cg19096424 chr1:120255104 PHGDH 0.58 8.23 0.41 4.29e-15 Breast cancer; LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC trans rs12200782 0.872 rs41266837 chr6:26409729 G/A cg18180407 chr1:55047736 ACOT11 0.44 6.01 0.31 4.8e-9 Small cell lung carcinoma; LUSC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg18306943 chr3:40428807 ENTPD3 0.41 6.23 0.32 1.43e-9 Renal cell carcinoma; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg11081185 chr11:208423 RIC8A;BET1L 0.39 6.32 0.33 8.43e-10 Triglycerides; LUSC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg14668632 chr7:2872130 GNA12 -0.43 -6.1 -0.32 2.95e-9 Height; LUSC cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg04111992 chr7:158790115 NA 0.36 5.85 0.3 1.19e-8 Facial morphology (factor 20); LUSC cis rs2857891 0.817 rs2857902 chr11:6980256 C/G cg14883916 chr11:6947541 ZNF215 0.45 5.83 0.3 1.29e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg05025164 chr4:1340916 KIAA1530 0.64 9.86 0.48 2.59e-20 Longevity; LUSC cis rs2219968 1.000 rs6982487 chr8:78972260 C/A cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs17125944 0.556 rs1952088 chr14:53319832 A/C cg00686598 chr14:53173677 PSMC6 -0.62 -5.82 -0.3 1.36e-8 Alzheimer's disease (late onset); LUSC cis rs295140 0.803 rs4516415 chr2:201129608 C/G cg04283868 chr2:201171347 SPATS2L 0.41 5.95 0.31 6.78e-9 QT interval; LUSC cis rs4660306 0.961 rs1494813 chr1:45957290 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.15 -0.36 5.48e-12 Homocysteine levels; LUSC cis rs8072100 0.790 rs11656856 chr17:45714671 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.41 6.53 0.34 2.43e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9303280 0.901 rs7359623 chr17:38049589 C/T cg19468946 chr17:37922297 IKZF3 -0.38 -5.91 -0.31 8.66e-9 Self-reported allergy; LUSC cis rs2652834 0.950 rs2729789 chr15:63400345 G/A cg05507819 chr15:63340323 TPM1 0.67 8.15 0.41 7.6e-15 HDL cholesterol; LUSC cis rs11792861 0.505 rs12377869 chr9:111907803 C/A cg05043794 chr9:111880884 C9orf5 -0.26 -6.0 -0.31 5.07e-9 Menarche (age at onset); LUSC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg04121214 chr22:50244548 NA -0.34 -5.66 -0.3 3.2e-8 Schizophrenia; LUSC cis rs6121246 0.529 rs6060145 chr20:30178631 T/C cg21427119 chr20:30132790 HM13 -0.44 -5.77 -0.3 1.82e-8 Mean corpuscular hemoglobin; LUSC cis rs6840360 1.000 rs6535813 chr4:152599652 A/T cg22705602 chr4:152727874 NA -0.27 -5.7 -0.3 2.66e-8 Intelligence (multi-trait analysis); LUSC cis rs782590 0.818 rs2627765 chr2:55883317 G/T cg18811423 chr2:55921094 PNPT1 0.78 13.14 0.58 4.31e-32 Metabolic syndrome; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22450693 chr17:48624483 SPATA20 -0.41 -6.19 -0.32 1.73e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4144743 0.759 rs67972765 chr17:45318326 G/A cg18085866 chr17:45331354 ITGB3 -0.77 -7.51 -0.38 5.29e-13 Body mass index; LUSC cis rs36051895 0.632 rs7850484 chr9:5147817 C/T cg02405213 chr9:5042618 JAK2 -0.52 -7.22 -0.37 3.47e-12 Pediatric autoimmune diseases; LUSC cis rs7940866 0.809 rs2324317 chr11:130877142 T/C cg12179176 chr11:130786555 SNX19 0.6 9.51 0.46 3.76e-19 Schizophrenia; LUSC cis rs4356932 1.000 rs7684889 chr4:76963264 T/A cg00809888 chr4:76862425 NAAA 0.36 6.0 0.31 5.07e-9 Blood protein levels; LUSC cis rs2667011 0.654 rs2465668 chr2:160838391 T/C cg06573604 chr2:160760825 LY75 -0.5 -6.36 -0.33 6.7e-10 Bilirubin levels; LUSC cis rs11955175 1.000 rs11951044 chr5:40671189 G/A cg04002187 chr5:40835754 RPL37 0.67 5.87 0.31 1.04e-8 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.913 rs11098496 chr4:120167466 C/G cg25214090 chr10:38739885 LOC399744 0.47 6.86 0.35 3.32e-11 Corneal astigmatism; LUSC cis rs2439831 0.850 rs28509275 chr15:44098105 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.91 8.54 0.42 4.93e-16 Lung cancer in ever smokers; LUSC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg18827107 chr12:86230957 RASSF9 -0.46 -6.87 -0.35 3.16e-11 Major depressive disorder; LUSC cis rs2652834 0.718 rs2729829 chr15:63395484 C/T cg05507819 chr15:63340323 TPM1 0.54 6.96 0.36 1.82e-11 HDL cholesterol; LUSC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg11247378 chr22:39784982 NA 0.61 11.83 0.54 3.34e-27 IgG glycosylation; LUSC cis rs11098499 0.754 rs878376 chr4:120237702 G/A cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC trans rs11098499 0.954 rs34858317 chr4:120387110 A/C cg25214090 chr10:38739885 LOC399744 0.57 8.42 0.42 1.1e-15 Corneal astigmatism; LUSC cis rs6456156 0.586 rs2001114 chr6:167486578 A/G cg07741184 chr6:167504864 NA 0.43 7.49 0.38 6.4e-13 Primary biliary cholangitis; LUSC cis rs9479482 0.967 rs3860823 chr6:150356526 A/G cg25797454 chr6:150327115 RAET1K 0.32 7.62 0.38 2.62e-13 Alopecia areata; LUSC cis rs9650657 0.547 rs11250099 chr8:10818657 C/T cg27411982 chr8:10470053 RP1L1 0.37 5.73 0.3 2.27e-8 Neuroticism; LUSC cis rs11098499 0.820 rs28394116 chr4:120524283 T/G cg24375607 chr4:120327624 NA 0.73 11.24 0.52 4.6e-25 Corneal astigmatism; LUSC cis rs7824557 0.736 rs35392635 chr8:11164349 G/C cg21775007 chr8:11205619 TDH 0.7 11.29 0.53 2.85e-25 Retinal vascular caliber; LUSC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg08949735 chr16:89699720 DPEP1 -0.23 -5.76 -0.3 1.89e-8 Vitiligo; LUSC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -8.54 -0.42 4.67e-16 Hemoglobin concentration; LUSC cis rs897984 0.542 rs11864839 chr16:31095251 G/C cg02466173 chr16:30829666 NA -0.5 -9.55 -0.46 2.91e-19 Dementia with Lewy bodies; LUSC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg03517284 chr6:25882590 NA -0.37 -6.07 -0.32 3.46e-9 Intelligence (multi-trait analysis); LUSC cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.49 6.81 0.35 4.68e-11 Multiple sclerosis; LUSC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg04972856 chr6:88032051 C6orf162;GJB7 0.51 10.02 0.48 7.88e-21 Monocyte percentage of white cells; LUSC cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg16230307 chr14:35515116 FAM177A1 0.79 10.05 0.48 6.13e-21 Psoriasis; LUSC cis rs7726839 0.574 rs72707007 chr5:661856 T/C cg16624210 chr5:671434 TPPP 0.46 5.94 0.31 7.33e-9 Obesity-related traits; LUSC cis rs9326248 0.581 rs10790167 chr11:116800943 T/C cg01368799 chr11:117014884 PAFAH1B2 0.58 8.79 0.43 7.97e-17 Blood protein levels; LUSC cis rs72772090 0.539 rs3333 chr5:96115111 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -6.55 -0.34 2.11e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11645898 0.935 rs72787078 chr16:72158493 C/T cg14768367 chr16:72042858 DHODH -0.66 -7.41 -0.38 1.05e-12 Blood protein levels; LUSC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg06634786 chr22:41940651 POLR3H -0.51 -5.92 -0.31 8.1e-9 Vitiligo; LUSC cis rs2639990 1.000 rs655156 chr18:72898181 T/C cg18449964 chr18:72917101 ZADH2 0.46 5.77 0.3 1.79e-8 Vascular endothelial growth factor levels; LUSC cis rs9916302 0.706 rs439537 chr17:37734482 T/C cg07936489 chr17:37558343 FBXL20 -0.81 -9.86 -0.47 2.7e-20 Glomerular filtration rate (creatinine); LUSC cis rs10746514 0.833 rs2026302 chr1:232264047 A/G cg09506761 chr1:232265262 NA -0.56 -9.74 -0.47 6.56e-20 Response to statin therapy; LUSC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg00255919 chr5:131827918 IRF1 0.43 8.27 0.41 3.31e-15 Asthma (sex interaction); LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg08736216 chr1:53307985 ZYG11A 0.3 6.24 0.32 1.34e-9 Monocyte count; LUSC cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg03676636 chr4:99064102 C4orf37 0.36 7.83 0.39 6.75e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7618501 1.000 rs7374277 chr3:49784777 T/C cg13072238 chr3:49761600 GMPPB -0.4 -6.52 -0.34 2.6e-10 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.51 0.86 1.3e-98 Chronic sinus infection; LUSC cis rs1044826 0.642 rs432387 chr3:139231853 T/G cg00490450 chr3:139108681 COPB2 -0.46 -7.08 -0.36 8.58e-12 Obesity-related traits; LUSC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg09034736 chr1:150693464 HORMAD1 0.44 6.59 0.34 1.68e-10 Tonsillectomy; LUSC cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.82 0.68 1.93e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11630290 0.736 rs6494440 chr15:64145709 C/T cg12036633 chr15:63758958 NA 0.59 6.59 0.34 1.69e-10 Iris characteristics; LUSC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg19748678 chr4:122722346 EXOSC9 0.5 7.67 0.39 1.86e-13 Type 2 diabetes; LUSC cis rs3806843 1.000 rs10072015 chr5:140170655 A/T cg19875535 chr5:140030758 IK -0.5 -8.29 -0.41 2.89e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg13560548 chr3:10150139 C3orf24 0.5 7.09 0.36 8.1e-12 Alzheimer's disease; LUSC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg26727032 chr16:67993705 SLC12A4 -0.45 -5.94 -0.31 7.32e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6669072 0.585 rs1025961 chr1:91264048 T/C cg08895590 chr1:91227319 NA -0.27 -5.8 -0.3 1.54e-8 Cognitive function; LUSC cis rs473651 0.740 rs502349 chr2:239318389 C/T cg18131467 chr2:239335373 ASB1 0.96 20.73 0.75 6.01e-62 Multiple system atrophy; LUSC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg01475377 chr6:109611718 NA -0.46 -8.37 -0.42 1.59e-15 Reticulocyte fraction of red cells; LUSC cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -7.07 -0.36 9.07e-12 Monocyte percentage of white cells; LUSC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg12292205 chr6:26970375 C6orf41 -0.56 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs2041895 0.509 rs2024518 chr12:107296902 G/A cg13944111 chr12:107296891 NA 0.36 6.27 0.32 1.15e-9 Glaucoma (low intraocular pressure); LUSC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.6 10.06 0.48 5.68e-21 Lymphocyte counts; LUSC cis rs1801251 0.711 rs2592117 chr2:233735693 C/T cg25237894 chr2:233734115 C2orf82 -0.35 -6.6 -0.34 1.62e-10 Coronary artery disease; LUSC cis rs9287719 0.935 rs6751075 chr2:10723546 C/G cg03983476 chr2:10830698 NOL10 -0.37 -5.66 -0.3 3.31e-8 Prostate cancer; LUSC cis rs7615316 0.779 rs4608715 chr3:142051147 T/C cg16271453 chr3:142027066 XRN1 -0.4 -6.98 -0.36 1.55e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6906287 0.647 rs3890198 chr6:118706447 T/C cg21191810 chr6:118973309 C6orf204 0.33 5.86 0.31 1.1e-8 Electrocardiographic conduction measures; LUSC cis rs9287719 0.967 rs6744599 chr2:10747013 C/G cg00105475 chr2:10696890 NA -0.35 -5.77 -0.3 1.8e-8 Prostate cancer; LUSC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg15595755 chr5:1867978 NA 0.46 8.49 0.42 6.64e-16 Cardiovascular disease risk factors; LUSC cis rs8141529 0.748 rs132528 chr22:29295898 C/T cg02153584 chr22:29168773 CCDC117 -0.58 -8.66 -0.43 2.01e-16 Lymphocyte counts; LUSC cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg03264133 chr6:25882463 NA -0.5 -9.11 -0.45 7.57e-18 Blood metabolite levels; LUSC cis rs838147 0.563 rs281379 chr19:49214274 C/T cg21064579 chr19:49206444 FUT2 0.35 6.41 0.33 4.89e-10 Dietary macronutrient intake; LUSC cis rs17270561 0.609 rs4711101 chr6:25741970 A/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg16339924 chr4:17578868 LAP3 0.52 7.99 0.4 2.15e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.645 rs28478790 chr11:50054322 C/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg00431813 chr7:1051703 C7orf50 -0.46 -7.69 -0.39 1.66e-13 Longevity;Endometriosis; LUSC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg07211511 chr3:129823064 LOC729375 -0.6 -8.03 -0.4 1.69e-14 Blood pressure (smoking interaction); LUSC cis rs72781680 0.898 rs17462670 chr2:24026579 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs12365397 0.526 rs11037263 chr11:43161203 A/C cg03447554 chr11:43094025 NA 0.35 5.79 0.3 1.59e-8 Migraine; LUSC cis rs8014204 0.816 rs28426374 chr14:75346740 C/T cg08847533 chr14:75593920 NEK9 -0.41 -6.03 -0.31 4.32e-9 Caffeine consumption; LUSC cis rs763014 0.966 rs15564 chr16:677854 G/T cg09263875 chr16:632152 PIGQ 0.71 13.45 0.59 2.88e-33 Height; LUSC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg18240062 chr17:79603768 NPLOC4 0.58 9.87 0.48 2.58e-20 Eye color traits; LUSC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg22535103 chr8:58192502 C8orf71 0.74 7.66 0.39 2.09e-13 Developmental language disorder (linguistic errors); LUSC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg13683864 chr3:40499215 RPL14 -0.97 -16.04 -0.66 2.37e-43 Renal cell carcinoma; LUSC cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg10729496 chr3:10149963 C3orf24 0.47 6.11 0.32 2.83e-9 Alzheimer's disease; LUSC cis rs7267979 0.966 rs454723 chr20:25438928 G/C cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs62458065 0.513 rs7788809 chr7:32552622 T/A cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.92 -0.31 7.8e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC cis rs4713675 0.584 rs4711339 chr6:33667199 A/G cg14003231 chr6:33640908 ITPR3 0.31 5.99 0.31 5.39e-9 Plateletcrit; LUSC trans rs9747201 0.832 rs4072580 chr17:80160337 A/C cg07393940 chr7:158741817 NA 0.51 8.24 0.41 3.97e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg27037943 chr1:84972490 SPATA1;GNG5 -0.47 -6.38 -0.33 5.98e-10 Hepatitis; LUSC cis rs2635047 1.000 rs2635047 chr18:44736336 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.77 0.35 5.96e-11 Educational attainment; LUSC cis rs11031096 0.678 rs11031184 chr11:4186192 C/T cg18678763 chr11:4115507 RRM1 -0.43 -6.33 -0.33 7.81e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs12479064 0.505 rs62153764 chr2:99818612 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.69 -7.94 -0.4 3.14e-14 Chronic sinus infection; LUSC cis rs7223966 1.000 rs8081612 chr17:61724695 A/G cg00945038 chr17:61921165 SMARCD2 -0.38 -5.8 -0.3 1.53e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs17253792 0.822 rs79398217 chr14:56067350 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs9457247 1.000 rs408040 chr6:167398903 A/T cg07741184 chr6:167504864 NA 0.36 6.53 0.34 2.52e-10 Crohn's disease; LUSC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg22800045 chr5:56110881 MAP3K1 0.79 10.51 0.5 1.59e-22 Initial pursuit acceleration; LUSC cis rs1577917 0.740 rs9450302 chr6:86289673 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 7.52 0.38 5.26e-13 Response to antipsychotic treatment; LUSC cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg07606381 chr6:8435919 SLC35B3 0.74 12.66 0.57 2.9e-30 Motion sickness; LUSC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg12463550 chr7:65579703 CRCP -0.52 -7.5 -0.38 5.79e-13 Aortic root size; LUSC trans rs6598955 0.627 rs12143920 chr1:26575834 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg24675658 chr1:53192096 ZYG11B -0.65 -10.22 -0.49 1.63e-21 Monocyte count; LUSC cis rs7582180 0.629 rs36103184 chr2:100942634 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs8062405 0.824 rs153106 chr16:28526897 T/C cg16576597 chr16:28551801 NUPR1 0.28 5.68 0.3 2.93e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10782582 0.609 rs111914775 chr1:76319036 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.39 -0.33 5.45e-10 Daytime sleep phenotypes; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.09 -0.32 3.04e-9 Bipolar disorder and schizophrenia; LUSC cis rs16910800 1.000 rs1531809 chr11:23194373 A/T cg20040320 chr11:23191996 NA -0.45 -6.52 -0.34 2.6e-10 Cancer; LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs1215050 0.655 rs6842706 chr4:98499037 A/T cg05340658 chr4:99064831 C4orf37 -0.39 -5.81 -0.3 1.45e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg22907277 chr7:1156413 C7orf50 0.61 9.6 0.47 1.97e-19 Longevity;Endometriosis; LUSC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg06008330 chr7:65541103 ASL -0.41 -6.31 -0.33 8.66e-10 Aortic root size; LUSC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg03233332 chr7:66118400 NA -0.41 -6.05 -0.31 3.99e-9 Aortic root size; LUSC cis rs25645 0.792 rs8077456 chr17:38128765 C/G cg17467752 chr17:38218738 THRA -0.48 -6.65 -0.34 1.21e-10 Myeloid white cell count; LUSC cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg05347473 chr6:146136440 FBXO30 0.57 10.04 0.48 6.65e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs8078723 0.701 rs2305482 chr17:38140927 A/C cg17344932 chr17:38183730 MED24;SNORD124 0.43 7.11 0.36 7.11e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.18 0.32 1.88e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.97 0.36 1.72e-11 Cystic fibrosis severity; LUSC cis rs3796619 1.000 rs55741287 chr4:1094670 T/C cg27284194 chr4:1044797 NA 0.46 7.2 0.37 4.05e-12 Recombination rate (males); LUSC cis rs7927771 0.524 rs11039402 chr11:47826090 A/C cg20307385 chr11:47447363 PSMC3 0.45 6.52 0.34 2.68e-10 Subjective well-being; LUSC cis rs61931739 0.513 rs10743833 chr12:33897481 C/T cg06521331 chr12:34319734 NA -0.37 -5.98 -0.31 5.7e-9 Morning vs. evening chronotype; LUSC cis rs6665290 0.935 rs17528667 chr1:227201770 C/T cg10327440 chr1:227177885 CDC42BPA -1.2 -35.46 -0.89 2.82e-115 Myeloid white cell count; LUSC cis rs3857536 0.813 rs1029400 chr6:66952385 A/G cg07460842 chr6:66804631 NA -0.46 -6.36 -0.33 6.75e-10 Blood trace element (Cu levels); LUSC cis rs2798269 0.966 rs2798272 chr13:22136766 C/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.04 -0.31 4.15e-9 PR segment; LUSC cis rs35146811 0.538 rs3823642 chr7:99796072 T/C cg22906224 chr7:99728672 NA 0.47 6.54 0.34 2.36e-10 Coronary artery disease; LUSC cis rs55728055 0.661 rs56411340 chr22:31984476 G/T cg01338084 chr22:32026380 PISD 0.93 6.78 0.35 5.4e-11 Age-related hearing impairment; LUSC cis rs899997 0.862 rs12912524 chr15:78952756 G/A cg24631222 chr15:78858424 CHRNA5 -0.44 -5.94 -0.31 7.25e-9 Coronary artery disease or large artery stroke; LUSC cis rs737337 0.623 rs4804155 chr19:11334295 C/G cg00586551 chr19:11347513 LOC55908;DOCK6 0.63 8.64 0.43 2.38e-16 HDL cholesterol;HDL cholesterol levels; LUSC trans rs6852435 1.000 rs62335857 chr4:175309122 C/T cg23753247 chr11:8615842 STK33 -0.53 -5.97 -0.31 5.91e-9 Response to acetaminophen (hepatotoxicity); LUSC cis rs977987 0.806 rs11641587 chr16:75464419 G/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.42e-11 Dupuytren's disease; LUSC cis rs73206853 0.841 rs11065663 chr12:110988886 G/T cg12870014 chr12:110450643 ANKRD13A 0.66 7.29 0.37 2.25e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2197308 0.565 rs4123923 chr12:37857684 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.81 0.65 1.96e-42 Morning vs. evening chronotype; LUSC cis rs9300255 0.602 rs1716164 chr12:123663660 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.34 -0.33 7.25e-10 Neutrophil percentage of white cells; LUSC cis rs7819412 0.668 rs920047 chr8:11087475 C/T cg21775007 chr8:11205619 TDH -0.49 -7.35 -0.37 1.55e-12 Triglycerides; LUSC trans rs11098499 0.908 rs71614449 chr4:120387055 C/T cg25214090 chr10:38739885 LOC399744 0.57 8.42 0.42 1.1e-15 Corneal astigmatism; LUSC cis rs524023 0.957 rs893006 chr11:64365796 C/A cg07220939 chr11:64358617 SLC22A12 -0.23 -6.1 -0.32 2.99e-9 Urate levels in obese individuals; LUSC cis rs478304 0.934 rs1193692 chr11:65504069 A/C cg27068330 chr11:65405492 SIPA1 0.61 9.03 0.44 1.39e-17 Acne (severe); LUSC cis rs7786877 0.583 rs41303510 chr7:100226129 C/T cg00334542 chr7:100209784 MOSPD3 -0.67 -7.52 -0.38 5.23e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs17818399 0.926 rs7590693 chr2:46823992 G/A cg02822958 chr2:46747628 ATP6V1E2 0.43 6.66 0.34 1.15e-10 Height; LUSC cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg22782873 chr19:19639568 YJEFN3 -0.48 -6.11 -0.32 2.7e-9 Bipolar disorder; LUSC cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.9e-23 Bladder cancer; LUSC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg26769984 chr7:1090371 C7orf50 0.57 7.69 0.39 1.69e-13 Bronchopulmonary dysplasia; LUSC cis rs10504073 0.584 rs55908480 chr8:49923431 G/A cg00325661 chr8:49890786 NA 0.7 11.22 0.52 5.35e-25 Blood metabolite ratios; LUSC trans rs9944715 0.954 rs9675387 chr18:43798023 G/A cg01718231 chr17:29326311 RNF135 -0.53 -7.34 -0.37 1.68e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs12760731 0.623 rs61520802 chr1:178428494 G/A cg00404053 chr1:178313656 RASAL2 0.48 5.84 0.3 1.27e-8 Obesity-related traits; LUSC cis rs76419734 0.510 rs2193856 chr4:106742958 A/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.54 -6.06 -0.31 3.71e-9 Post bronchodilator FEV1; LUSC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg06558623 chr16:89946397 TCF25 1.1 9.65 0.47 1.34e-19 Skin colour saturation; LUSC cis rs1023500 0.596 rs5758562 chr22:42448238 C/G cg15557168 chr22:42548783 NA -0.41 -6.18 -0.32 1.88e-9 Schizophrenia; LUSC cis rs9902453 0.967 rs4493117 chr17:28489770 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.84 0.44 5.47e-17 Coffee consumption (cups per day); LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg08200582 chr11:442649 ANO9 -0.52 -6.04 -0.31 4.09e-9 Body mass index; LUSC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs977987 0.806 rs4888404 chr16:75428097 G/A cg03315344 chr16:75512273 CHST6 0.48 9.05 0.44 1.17e-17 Dupuytren's disease; LUSC cis rs7904985 0.924 rs2217223 chr10:88111630 A/G cg07322936 chr10:88137208 NA 0.6 8.05 0.4 1.44e-14 Barrett's esophagus; LUSC cis rs2762353 0.935 rs2328895 chr6:25802083 C/T cg03264133 chr6:25882463 NA -0.42 -7.26 -0.37 2.76e-12 Blood metabolite levels; LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs13082711 0.513 rs66472045 chr3:27242887 G/A cg02860705 chr3:27208620 NA 0.64 11.15 0.52 9.46e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.98 0.48 1.08e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4450131 0.522 rs4962680 chr10:126358833 C/T cg20435097 chr10:126320824 FAM53B 0.24 6.07 0.32 3.41e-9 White blood cell count (basophil); LUSC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg21433313 chr16:3507492 NAT15 -0.39 -6.14 -0.32 2.34e-9 Body mass index (adult); LUSC cis rs6709815 0.902 rs13020432 chr2:219668211 C/T cg02176678 chr2:219576539 TTLL4 -0.52 -9.13 -0.45 6.64e-18 Reticulocyte count;High light scatter reticulocyte count; LUSC cis rs7089973 0.624 rs11196940 chr10:116593791 T/G cg03647239 chr10:116582469 FAM160B1 0.45 7.19 0.37 4.19e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg08807101 chr21:30365312 RNF160 0.67 10.59 0.5 8.53e-23 Selective IgA deficiency; LUSC cis rs7772486 0.902 rs1125462 chr6:146417832 A/G cg05347473 chr6:146136440 FBXO30 0.42 6.95 0.36 1.92e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25587211 chr3:43663662 ANO10 0.44 6.67 0.34 1.04e-10 Triglycerides; LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg04518342 chr5:131593106 PDLIM4 0.45 7.88 0.4 4.52e-14 Acylcarnitine levels; LUSC cis rs7561273 0.609 rs10189243 chr2:24293756 C/T cg06627628 chr2:24431161 ITSN2 -0.51 -6.83 -0.35 3.93e-11 Quantitative traits; LUSC cis rs7020830 0.505 rs12553878 chr9:37095705 C/T cg14294708 chr9:37120828 ZCCHC7 0.68 11.38 0.53 1.42e-25 Schizophrenia; LUSC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.13 -0.41 8.39e-15 Lung cancer; LUSC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg19678392 chr7:94953810 PON1 -0.36 -5.65 -0.3 3.48e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7523050 0.730 rs12729728 chr1:109431110 C/A cg08274380 chr1:109419600 GPSM2 1.12 10.87 0.51 8.87e-24 Fat distribution (HIV); LUSC trans rs7937682 0.575 rs7114617 chr11:111768173 A/T cg18187862 chr3:45730750 SACM1L -0.51 -6.27 -0.32 1.1e-9 Primary sclerosing cholangitis; LUSC cis rs12310956 0.510 rs1825903 chr12:33870437 G/C cg06521331 chr12:34319734 NA -0.37 -6.16 -0.32 2.07e-9 Morning vs. evening chronotype; LUSC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg06618935 chr21:46677482 NA -0.4 -8.12 -0.41 9.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1371867 0.875 rs1619759 chr8:101337560 T/C cg06002616 chr8:101225028 SPAG1 -0.43 -6.97 -0.36 1.68e-11 Atrioventricular conduction; LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg27068330 chr11:65405492 SIPA1 0.52 6.03 0.31 4.3e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs4363385 0.747 rs1015996 chr1:152976108 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC cis rs4423214 0.840 rs1792234 chr11:71182018 T/C cg05163923 chr11:71159392 DHCR7 -0.77 -10.11 -0.48 3.81e-21 Vitamin D levels; LUSC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg24250549 chr1:154909240 PMVK 0.66 11.06 0.52 2.01e-24 Prostate cancer; LUSC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg02807482 chr3:125708958 NA -0.52 -6.5 -0.33 2.98e-10 Blood pressure (smoking interaction); LUSC cis rs7119 0.604 rs2458035 chr15:77862806 G/A cg27398640 chr15:77910606 LINGO1 0.36 7.92 0.4 3.62e-14 Type 2 diabetes; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg00698688 chr19:49055432 SULT2B1 -0.24 -6.26 -0.32 1.21e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.94e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg22823121 chr1:150693482 HORMAD1 0.61 9.35 0.46 1.34e-18 Tonsillectomy; LUSC trans rs6951245 0.786 rs77943789 chr7:1140158 C/T cg13565492 chr6:43139072 SRF -0.58 -6.57 -0.34 1.97e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg10523679 chr1:76189770 ACADM -0.49 -7.14 -0.36 5.99e-12 Daytime sleep phenotypes; LUSC cis rs35146811 0.844 rs12705070 chr7:99656927 A/G cg13334819 chr7:99746414 C7orf59 -0.44 -6.04 -0.31 4.18e-9 Coronary artery disease; LUSC cis rs10927875 0.632 rs1122068 chr1:16127480 G/C cg21385522 chr1:16154831 NA -0.98 -18.47 -0.71 5.65e-53 Dilated cardiomyopathy; LUSC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg00750074 chr16:89608354 SPG7 -0.56 -10.09 -0.48 4.63e-21 Multiple myeloma (IgH translocation); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21497602 chr12:12715811 DUSP16 0.76 6.05 0.31 3.9e-9 Cognitive performance; LUSC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg06618935 chr21:46677482 NA -0.34 -7.02 -0.36 1.24e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs4332037 0.802 rs12113633 chr7:1932936 G/A cg11693508 chr17:37793320 STARD3 0.65 7.9 0.4 4.19e-14 Bipolar disorder; LUSC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg19748678 chr4:122722346 EXOSC9 0.49 7.55 0.38 4.29e-13 Type 2 diabetes; LUSC cis rs76878669 0.561 rs7105015 chr11:66159390 A/G cg18002602 chr11:66138449 SLC29A2 0.47 8.33 0.41 2.16e-15 Educational attainment (years of education); LUSC cis rs6076065 0.748 rs4142246 chr20:23388975 A/G cg11657817 chr20:23433608 CST11 0.54 11.1 0.52 1.37e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs62458065 0.513 rs10265319 chr7:32571564 A/C cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.95 -0.31 6.86e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs3126085 0.935 rs11204937 chr1:152193851 C/T cg03465714 chr1:152285911 FLG -0.41 -5.89 -0.31 9.28e-9 Atopic dermatitis; LUSC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg20302533 chr7:39170763 POU6F2 0.54 9.08 0.44 9.88e-18 IgG glycosylation; LUSC cis rs17270561 0.636 rs7775354 chr6:25745266 T/A cg16482183 chr6:26056742 HIST1H1C 0.64 9.14 0.45 6.03e-18 Iron status biomarkers; LUSC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg03676636 chr4:99064102 C4orf37 0.38 8.07 0.4 1.3e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg08470875 chr2:26401718 FAM59B -0.71 -9.6 -0.47 1.92e-19 Gut microbiome composition (summer); LUSC cis rs9318086 0.712 rs9510916 chr13:24442789 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.42 6.23 0.32 1.39e-9 Myopia (pathological); LUSC cis rs2050392 0.771 rs303446 chr10:30728489 C/T cg18806716 chr10:30721971 MAP3K8 -0.48 -8.01 -0.4 1.93e-14 Inflammatory bowel disease; LUSC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.71 -8.92 -0.44 3.11e-17 Gut microbiome composition (summer); LUSC cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 11.96 0.55 1.11e-27 Colorectal cancer; LUSC cis rs9393777 0.720 rs35769282 chr6:26999908 G/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.54 -6.36 -0.33 6.81e-10 Intelligence (multi-trait analysis); LUSC trans rs953492 0.591 rs10803128 chr1:243393842 T/C cg25284624 chr1:224180302 NA -0.42 -6.34 -0.33 7.64e-10 Diastolic blood pressure; LUSC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg03909863 chr11:638404 DRD4 -0.39 -5.74 -0.3 2.17e-8 Systemic lupus erythematosus; LUSC cis rs9837602 0.507 rs1059905 chr3:99516879 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -7.26 -0.37 2.69e-12 Breast cancer; LUSC cis rs10740039 0.842 rs7915540 chr10:62406296 G/C cg18175470 chr10:62150864 ANK3 -0.46 -6.86 -0.35 3.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.46e-11 Tonsillectomy; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs17818399 0.926 rs1824050 chr2:46839477 T/C cg02822958 chr2:46747628 ATP6V1E2 0.39 6.05 0.31 3.87e-9 Height; LUSC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg09455208 chr3:40491958 NA 0.59 10.39 0.49 4.39e-22 Renal cell carcinoma; LUSC cis rs4363385 0.818 rs4845522 chr1:153011099 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs10740039 0.804 rs7900848 chr10:62415651 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs13256369 0.802 rs13256404 chr8:8562974 T/C cg00074818 chr8:8560427 CLDN23 0.59 9.8 0.47 4.21e-20 Obesity-related traits; LUSC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.85 0.44 5.14e-17 Schizophrenia; LUSC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -6.67 -0.34 1.06e-10 Developmental language disorder (linguistic errors); LUSC cis rs7122539 0.603 rs508443 chr11:66509369 C/T cg18002602 chr11:66138449 SLC29A2 0.35 6.22 0.32 1.53e-9 HIV-1 susceptibility; LUSC cis rs6964587 0.692 rs10271430 chr7:91710466 G/C cg17063962 chr7:91808500 NA 0.56 9.36 0.46 1.23e-18 Breast cancer; LUSC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg02079420 chr8:82753780 SNX16 0.43 7.47 0.38 7.14e-13 Diastolic blood pressure; LUSC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg26597838 chr10:835615 NA 1.21 15.68 0.65 6.59e-42 Eosinophil percentage of granulocytes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05663418 chr16:3451086 ZNF174;ZNF434 0.46 6.15 0.32 2.25e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11148252 0.904 rs9568732 chr13:52993412 A/G cg02158880 chr13:53174818 NA -0.39 -6.73 -0.35 7.6e-11 Lewy body disease; LUSC cis rs9323205 0.954 rs4898682 chr14:51639577 C/T cg23942311 chr14:51606299 NA -0.38 -7.81 -0.39 7.48e-14 Cancer; LUSC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.69 0.5 3.96e-23 Schizophrenia; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg18758796 chr5:131593413 PDLIM4 -0.42 -6.76 -0.35 6.25e-11 Breast cancer; LUSC cis rs977987 0.800 rs12935787 chr16:75332335 C/T cg03315344 chr16:75512273 CHST6 0.47 8.82 0.43 6.26e-17 Dupuytren's disease; LUSC cis rs10193935 1.000 rs10193935 chr2:42419829 C/T cg27598129 chr2:42591480 NA -0.61 -8.57 -0.42 4.01e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg10802521 chr3:52805072 NEK4 -0.42 -6.47 -0.33 3.42e-10 Electroencephalogram traits; LUSC cis rs778371 0.723 rs12619195 chr2:233678326 G/A cg08000102 chr2:233561755 GIGYF2 -0.8 -13.76 -0.6 1.95e-34 Schizophrenia; LUSC trans rs8072100 0.790 rs11079783 chr17:45686016 C/T cg04995722 chr7:26192034 NFE2L3 0.41 6.47 0.33 3.49e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs17270561 0.609 rs9358871 chr6:25726675 G/A cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC cis rs8044868 0.530 rs2288002 chr16:72057282 A/G cg16579770 chr16:72058938 DHODH 0.34 5.77 0.3 1.85e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg02269571 chr22:50332266 NA -0.57 -8.59 -0.43 3.41e-16 Schizophrenia; LUSC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg06618935 chr21:46677482 NA -0.38 -7.67 -0.39 1.94e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15929228 chr2:240323491 HDAC4 -0.47 -6.32 -0.33 8.58e-10 Bipolar disorder and schizophrenia; LUSC trans rs2228479 0.681 rs2270461 chr16:89972345 C/T cg24644049 chr4:85504048 CDS1 -0.64 -6.69 -0.34 9.38e-11 Skin colour saturation; LUSC cis rs6429082 0.683 rs2131920 chr1:235579912 T/A cg26050004 chr1:235667680 B3GALNT2 -0.56 -7.95 -0.4 2.89e-14 Adiposity; LUSC trans rs3749237 1.000 rs11717256 chr3:49868520 C/T cg21659725 chr3:3221576 CRBN 0.6 8.77 0.43 9.54e-17 Resting heart rate; LUSC cis rs4148883 0.689 rs2851275 chr4:100024883 A/G cg12011299 chr4:100065546 ADH4 0.46 7.88 0.4 4.8e-14 Alcohol dependence; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.86 -0.35 3.41e-11 Bipolar disorder and schizophrenia; LUSC cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg23649088 chr2:200775458 C2orf69 -0.55 -6.98 -0.36 1.64e-11 Schizophrenia; LUSC cis rs2219968 0.923 rs7004112 chr8:78941331 G/T cg00738934 chr8:78996279 NA 0.39 6.97 0.36 1.66e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs6502050 0.635 rs9889327 chr17:80087839 G/A cg07393940 chr7:158741817 NA 0.38 6.74 0.35 6.87e-11 Life satisfaction; LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -6.38 -0.33 6.02e-10 Longevity;Endometriosis; LUSC cis rs7903847 0.642 rs7092350 chr10:99140218 A/T cg20016023 chr10:99160130 RRP12 -0.33 -8.19 -0.41 5.76e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs240764 0.658 rs4571568 chr6:101223955 T/A cg09795085 chr6:101329169 ASCC3 -0.42 -6.11 -0.32 2.74e-9 Neuroticism; LUSC cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg09877947 chr5:131593287 PDLIM4 -0.37 -6.0 -0.31 5.25e-9 Blood metabolite levels; LUSC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.3 -0.33 9.58e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs8141529 0.509 rs7287124 chr22:29239157 A/G cg02153584 chr22:29168773 CCDC117 0.54 8.12 0.41 9.23e-15 Lymphocyte counts; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00619347 chr3:149688574 PFN2 -0.46 -6.01 -0.31 4.96e-9 Bipolar disorder and schizophrenia; LUSC cis rs11190604 0.943 rs11190568 chr10:102224277 C/T cg07080220 chr10:102295463 HIF1AN 0.67 8.6 0.43 3.17e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg06022373 chr22:39101656 GTPBP1 0.89 14.68 0.63 5.52e-38 Menopause (age at onset); LUSC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.46 -0.46 5.68e-19 Electroencephalogram traits; LUSC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18099408 chr3:52552593 STAB1 -0.37 -6.48 -0.33 3.33e-10 Electroencephalogram traits; LUSC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg22875332 chr1:76189707 ACADM -0.76 -11.27 -0.53 3.37e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4474465 0.850 rs4945289 chr11:78245334 G/T cg27205649 chr11:78285834 NARS2 0.48 5.84 0.3 1.24e-8 Alzheimer's disease (survival time); LUSC cis rs76878669 0.561 rs55998145 chr11:66152586 A/G cg24851651 chr11:66362959 CCS -0.38 -6.08 -0.32 3.37e-9 Educational attainment (years of education); LUSC cis rs7804356 0.906 rs73069540 chr7:26904770 C/T cg03456212 chr7:26904342 SKAP2 -0.58 -6.65 -0.34 1.22e-10 Type 1 diabetes; LUSC trans rs12317459 0.591 rs11830781 chr12:83205083 G/A cg10237817 chr1:154519846 TDRD10 0.31 6.14 0.32 2.28e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12989701 0.877 rs13029812 chr2:127872622 A/G cg08168897 chr2:127865431 BIN1 0.71 9.36 0.46 1.2e-18 Alzheimer's disease (late onset); LUSC cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC trans rs11098499 1.000 rs28374891 chr4:120183550 G/A cg25214090 chr10:38739885 LOC399744 0.46 6.74 0.35 7.06e-11 Corneal astigmatism; LUSC cis rs17102423 0.589 rs4899162 chr14:65614126 G/T cg11161011 chr14:65562177 MAX -0.62 -8.39 -0.42 1.39e-15 Obesity-related traits; LUSC cis rs7100689 0.646 rs10736345 chr10:82134140 C/T cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC trans rs72674100 1.000 rs28656993 chr4:97965682 C/T cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs644799 0.511 rs12791736 chr11:95475399 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.82 0.47 3.67e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg06544989 chr22:39130855 UNC84B 0.37 6.41 0.33 5.04e-10 Menopause (age at onset); LUSC cis rs877282 1.000 rs2004479 chr10:770854 G/A cg17470449 chr10:769945 NA 0.53 7.53 0.38 4.63e-13 Uric acid levels; LUSC trans rs3960554 0.674 rs113848658 chr7:75791858 G/A cg19862616 chr7:65841803 NCRNA00174 0.9 10.07 0.48 5.19e-21 Eotaxin levels; LUSC trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg13126279 chr21:47581558 C21orf56 0.49 7.46 0.38 7.5e-13 Testicular germ cell tumor; LUSC cis rs9393777 0.623 rs2093169 chr6:26495099 C/T cg05738196 chr6:26577821 NA -0.54 -5.93 -0.31 7.52e-9 Intelligence (multi-trait analysis); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg18993701 chr15:65715356 IGDCC4 0.48 6.06 0.31 3.71e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg14196790 chr5:131705035 SLC22A5 0.48 8.18 0.41 6.2e-15 Blood metabolite levels; LUSC cis rs4820539 1.000 rs916584 chr22:23469433 A/G cg21100191 chr22:23484243 RTDR1 0.91 16.02 0.66 2.88e-43 Bone mineral density; LUSC trans rs853679 0.546 rs175597 chr6:27810626 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -7.93 -0.4 3.36e-14 Depression; LUSC cis rs76793172 1.000 rs60283385 chr19:46329079 T/C cg27118825 chr19:46318748 RSPH6A;SYMPK 0.46 5.69 0.3 2.75e-8 Eosinophil counts; LUSC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg18230493 chr5:56204884 C5orf35 -0.94 -14.41 -0.62 6.18e-37 Initial pursuit acceleration; LUSC cis rs9341808 0.683 rs7771449 chr6:80919977 C/T cg08355045 chr6:80787529 NA 0.58 10.2 0.49 1.97e-21 Sitting height ratio; LUSC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg04352962 chr1:209979756 IRF6 -0.5 -5.91 -0.31 8.51e-9 Cleft lip with or without cleft palate; LUSC cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.71 0.51 3.28e-23 Bladder cancer; LUSC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg18350739 chr11:68623251 NA 0.32 5.65 0.3 3.38e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2832191 0.967 rs1999321 chr21:30530233 A/C cg08807101 chr21:30365312 RNF160 0.68 11.44 0.53 8.68e-26 Dental caries; LUSC cis rs9902453 1.000 rs4795525 chr17:28388487 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC trans rs7618501 0.633 rs12485600 chr3:50025530 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 9.02 0.44 1.45e-17 Intelligence (multi-trait analysis); LUSC cis rs804280 0.509 rs35626932 chr8:11786932 C/A cg21775007 chr8:11205619 TDH 0.46 6.63 0.34 1.33e-10 Myopia (pathological); LUSC cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg16586182 chr3:47516702 SCAP 0.54 8.37 0.42 1.61e-15 Colorectal cancer; LUSC cis rs6977660 1.000 rs13237667 chr7:19820288 G/C cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs3126085 0.877 rs7535536 chr1:152193544 A/G cg03465714 chr1:152285911 FLG -0.41 -5.89 -0.31 9.28e-9 Atopic dermatitis; LUSC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg24154853 chr7:158122151 PTPRN2 -0.42 -8.24 -0.41 3.89e-15 Calcium levels; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg22963979 chr7:1858916 MAD1L1 -0.55 -8.4 -0.42 1.26e-15 Bipolar disorder and schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06035161 chr3:53915801 ACTR8 0.8 6.43 0.33 4.52e-10 Cognitive performance; LUSC cis rs5769707 0.632 rs135872 chr22:50009300 T/C cg10356904 chr22:49881777 NA -0.29 -5.77 -0.3 1.78e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.34 0.67 1.6e-44 Platelet count; LUSC cis rs35883536 0.647 rs7524322 chr1:101047730 C/G cg06223162 chr1:101003688 GPR88 0.45 8.37 0.42 1.56e-15 Monocyte count; LUSC cis rs701145 0.617 rs355775 chr3:154036129 A/G cg10247383 chr3:153839028 SGEF -0.47 -5.68 -0.3 2.87e-8 Coronary artery disease; LUSC cis rs12477438 0.765 rs13390672 chr2:99589829 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.51e-15 Chronic sinus infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26933736 chr6:83902998 RWDD2A;PGM3 -0.38 -6.02 -0.31 4.54e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11190604 1.000 rs2489053 chr10:102353341 A/G cg07080220 chr10:102295463 HIF1AN 0.69 9.27 0.45 2.39e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4589502 0.841 rs75991095 chr15:67123224 C/G cg12317470 chr15:67143691 NA 0.7 5.92 0.31 7.9e-9 Lung cancer (smoking interaction); LUSC cis rs826838 1.000 rs826851 chr12:39112639 A/G cg13010199 chr12:38710504 ALG10B -0.63 -10.77 -0.51 2.07e-23 Heart rate; LUSC cis rs1034435 0.723 rs713946 chr22:48891376 T/C cg05992904 chr22:48892994 FAM19A5 -0.4 -8.0 -0.4 2e-14 Late-onset Alzheimer's disease; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 9.8e-65 Prudent dietary pattern; LUSC cis rs5758511 0.633 rs5751258 chr22:42663871 C/G cg00645731 chr22:42541494 CYP2D7P1 0.58 10.23 0.49 1.45e-21 Birth weight; LUSC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg27129171 chr3:47204927 SETD2 0.76 13.55 0.6 1.2e-33 Colorectal cancer; LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg00290607 chr11:67383545 NA -0.36 -6.43 -0.33 4.3e-10 Mean corpuscular volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06789412 chr3:101405552 RPL24 0.4 7.1 0.36 7.34e-12 Triglycerides; LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.11e-9 Menopause (age at onset); LUSC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg05754148 chr16:3507555 NAT15 0.84 8.81 0.43 7.11e-17 Tuberculosis; LUSC cis rs9611565 0.568 rs2413656 chr22:42129357 G/T cg17376030 chr22:41985996 PMM1 -0.42 -5.75 -0.3 2.05e-8 Vitiligo; LUSC cis rs11158026 0.603 rs8022049 chr14:55462869 C/T cg04306507 chr14:55594613 LGALS3 -0.4 -7.41 -0.38 1.03e-12 Parkinson's disease; LUSC cis rs12621445 1 rs12621445 chr2:24154964 C/T cg20701182 chr2:24300061 SF3B14 0.77 7.73 0.39 1.25e-13 Immature fraction of reticulocytes; LUSC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg03929089 chr4:120376271 NA -1.0 -18.3 -0.71 2.56e-52 Height; LUSC cis rs67539049 1.000 rs3021512 chr8:11301601 G/C cg02771117 chr8:11279352 FAM167A;C8orf12 -0.39 -5.99 -0.31 5.36e-9 Itch intensity from mosquito bite; LUSC cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg05855489 chr10:104503620 C10orf26 0.67 9.06 0.44 1.15e-17 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg15147215 chr3:52552868 STAB1 -0.31 -6.11 -0.32 2.7e-9 Bipolar disorder; LUSC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.83 0.51 1.29e-23 Hip circumference adjusted for BMI; LUSC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg18230493 chr5:56204884 C5orf35 -0.55 -8.81 -0.43 6.91e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs3096299 0.967 rs2965830 chr16:89460290 T/C cg08392591 chr16:89556376 ANKRD11 0.39 5.75 0.3 2.03e-8 Multiple myeloma (IgH translocation); LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg18404041 chr3:52824283 ITIH1 -0.61 -11.76 -0.54 5.97e-27 Bipolar disorder; LUSC cis rs804280 0.509 rs12719915 chr8:11786255 A/G cg00405596 chr8:11794950 NA -0.36 -6.01 -0.31 4.92e-9 Myopia (pathological); LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg18301423 chr5:131593218 PDLIM4 0.47 7.36 0.37 1.41e-12 Acylcarnitine levels; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC cis rs2688608 0.592 rs10824032 chr10:75528130 G/A cg23231163 chr10:75533350 FUT11 -0.4 -6.55 -0.34 2.11e-10 Inflammatory bowel disease; LUSC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.64 9.84 0.47 3.11e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg08798685 chr6:27730294 NA -0.62 -5.94 -0.31 7.19e-9 Breast cancer; LUSC cis rs2835872 0.759 rs2835896 chr21:39066640 A/G cg20424643 chr21:39039972 KCNJ6 -0.37 -5.72 -0.3 2.43e-8 Electroencephalographic traits in alcoholism; LUSC cis rs12893668 0.638 rs11851616 chr14:104065600 G/A cg01849466 chr14:104193079 ZFYVE21 -0.45 -6.41 -0.33 4.89e-10 Reticulocyte count; LUSC cis rs9527 0.615 rs9733635 chr10:104711940 G/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.66 -0.34 1.15e-10 Arsenic metabolism; LUSC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg17211192 chr8:82754475 SNX16 0.81 11.11 0.52 1.32e-24 Diastolic blood pressure; LUSC cis rs72960926 0.744 rs2351778 chr6:74866814 T/G cg03266952 chr6:74778945 NA -0.83 -7.31 -0.37 2.05e-12 Metabolite levels (MHPG); LUSC cis rs4072705 0.646 rs915034 chr9:127244955 G/A cg13476313 chr9:127244764 NR5A1 0.35 6.78 0.35 5.37e-11 Menarche (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14965979 chr2:44588995 PREPL;C2orf34 -0.49 -6.38 -0.33 6.02e-10 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg14092988 chr3:52407081 DNAH1 0.31 6.01 0.31 4.93e-9 Bipolar disorder; LUSC cis rs9612 1.000 rs8105041 chr19:44258458 A/G cg08581076 chr19:44259116 C19orf61 0.53 6.71 0.34 8.22e-11 Exhaled nitric oxide output; LUSC cis rs7119 0.717 rs16968835 chr15:77734261 G/A cg05673287 chr15:77411982 SGK269 -0.44 -6.98 -0.36 1.59e-11 Type 2 diabetes; LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.51 0.46 3.94e-19 Bipolar disorder; LUSC cis rs12220238 1.000 rs10824113 chr10:75969018 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.12e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs11958404 0.932 rs72816552 chr5:157422376 G/A cg05962755 chr5:157440814 NA 0.49 6.09 0.32 3.09e-9 IgG glycosylation; LUSC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.62 0.47 1.72e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs854765 0.594 rs8066560 chr17:17728043 A/G cg09796270 chr17:17721594 SREBF1 -0.45 -7.98 -0.4 2.32e-14 Total body bone mineral density; LUSC trans rs1493916 1.000 rs990882 chr18:31398180 T/G cg15819921 chr19:927150 ARID3A -0.43 -6.25 -0.32 1.28e-9 Life satisfaction; LUSC cis rs6690583 0.623 rs12042910 chr1:85452580 G/A cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.02e-10 Serum sulfate level; LUSC cis rs5753618 0.539 rs2106294 chr22:31645759 C/T cg22777020 chr22:31556080 RNF185 -0.45 -5.88 -0.31 9.79e-9 Colorectal cancer; LUSC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg26850624 chr5:429559 AHRR -0.41 -7.92 -0.4 3.58e-14 Cystic fibrosis severity; LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg07507251 chr3:52567010 NT5DC2 0.32 5.91 0.31 8.59e-9 Bipolar disorder; LUSC cis rs9463078 0.547 rs4714822 chr6:44742290 T/C cg25276700 chr6:44698697 NA 0.3 6.33 0.33 7.67e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2398893 0.960 rs2153791 chr9:96744928 G/A cg14459158 chr9:96720562 NA 0.32 5.84 0.3 1.21e-8 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg04998671 chr14:104000505 TRMT61A -0.41 -6.03 -0.31 4.41e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg23711669 chr6:146136114 FBXO30 0.89 16.78 0.68 2.88e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs8113142 0.651 rs58606095 chr19:29096004 C/T cg04546413 chr19:29218101 NA 0.43 5.87 0.31 1.05e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.55 -0.34 2.14e-10 Monocyte percentage of white cells; LUSC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs16866061 0.926 rs1523919 chr2:225403615 G/A cg12698349 chr2:225449008 CUL3 0.87 13.42 0.59 3.78e-33 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs829883 0.659 rs11109528 chr12:98951362 G/A cg25150519 chr12:98850993 NA -0.64 -8.84 -0.44 5.54e-17 Colorectal adenoma (advanced); LUSC cis rs8141529 0.778 rs9625566 chr22:29162506 G/A cg15103426 chr22:29168792 CCDC117 0.55 7.18 0.37 4.47e-12 Lymphocyte counts; LUSC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg23630131 chr7:65973040 NA -0.2 -5.66 -0.3 3.22e-8 Aortic root size; LUSC cis rs66731853 0.769 rs530104 chr1:20895721 A/G cg04087271 chr1:20915334 CDA -0.46 -6.44 -0.33 4.26e-10 Mean corpuscular volume; LUSC cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.42 -7.79 -0.39 8.41e-14 Monocyte percentage of white cells; LUSC cis rs6580649 0.941 rs1018973 chr12:48441692 C/G cg24011408 chr12:48396354 COL2A1 0.46 6.09 0.32 3.16e-9 Lung cancer; LUSC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg21770322 chr7:97807741 LMTK2 0.4 7.03 0.36 1.19e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 0.756 rs2345572 chr6:167403441 A/T cg07741184 chr6:167504864 NA 0.39 6.98 0.36 1.64e-11 Crohn's disease; LUSC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg24110177 chr3:50126178 RBM5 0.57 9.24 0.45 3e-18 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.07 0.52 1.76e-24 Alzheimer's disease; LUSC cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.13 0.55 2.73e-28 Colorectal cancer; LUSC cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg13256891 chr4:100009986 ADH5 -0.54 -8.69 -0.43 1.7e-16 Alcohol dependence; LUSC cis rs2742417 0.603 rs2742370 chr3:45782098 T/C cg10512202 chr3:45649293 LIMD1 0.35 5.88 0.31 1.01e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11190604 0.666 rs7084768 chr10:102200497 T/C cg07080220 chr10:102295463 HIF1AN -0.59 -8.11 -0.41 9.48e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs36715 0.951 rs36698 chr5:127549749 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.53 6.93 0.35 2.18e-11 Breast cancer; LUSC cis rs60843830 0.661 rs55987018 chr2:106655 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.45 6.66 0.34 1.16e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7824557 0.767 rs1897951 chr8:11169854 C/T cg27411982 chr8:10470053 RP1L1 0.38 5.89 0.31 9.35e-9 Retinal vascular caliber; LUSC trans rs12637928 0.580 rs35156093 chr3:110209637 C/T cg17371621 chr15:61264283 RORA 0.36 5.96 0.31 6.29e-9 Neuroticism; LUSC cis rs240764 0.541 rs9390693 chr6:101239935 T/C cg09795085 chr6:101329169 ASCC3 0.44 6.27 0.32 1.13e-9 Neuroticism; LUSC cis rs7584330 0.554 rs74001383 chr2:238424418 T/C cg16989719 chr2:238392110 NA -0.41 -5.86 -0.31 1.13e-8 Prostate cancer; LUSC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg03526776 chr6:41159608 TREML2 -0.32 -6.1 -0.32 2.96e-9 Alzheimer's disease (late onset); LUSC cis rs11214589 1.000 rs11214589 chr11:113245048 C/T cg14159747 chr11:113255604 NA 0.27 6.63 0.34 1.39e-10 Neuroticism; LUSC cis rs3771570 1.000 rs62193205 chr2:242316512 C/T cg21155796 chr2:242212141 HDLBP 0.62 6.67 0.34 1.07e-10 Prostate cancer; LUSC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg04166393 chr7:2884313 GNA12 0.43 5.68 0.3 2.99e-8 Height; LUSC trans rs11039798 1.000 rs7928243 chr11:48589192 A/T cg03929089 chr4:120376271 NA 0.66 6.09 0.32 3.09e-9 Axial length; LUSC cis rs6546550 0.935 rs10865380 chr2:70091246 T/C cg02498382 chr2:70120550 SNRNP27 -0.29 -7.08 -0.36 8.57e-12 Prevalent atrial fibrillation; LUSC cis rs11122272 0.735 rs910824 chr1:231498773 C/G cg06096015 chr1:231504339 EGLN1 0.57 9.98 0.48 1.08e-20 Hemoglobin concentration; LUSC cis rs367943 0.933 rs451453 chr5:112808970 G/C cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs4664304 0.802 rs62175470 chr2:160858255 G/C cg23995753 chr2:160760732 LY75 -0.33 -6.14 -0.32 2.37e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs8044995 0.563 rs61602448 chr16:68377520 C/T cg05110241 chr16:68378359 PRMT7 -0.76 -8.7 -0.43 1.59e-16 Schizophrenia; LUSC cis rs10876993 0.928 rs1678540 chr12:58065002 A/G cg18357645 chr12:58087776 OS9 0.55 8.31 0.41 2.38e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg12311346 chr5:56204834 C5orf35 -0.9 -13.02 -0.58 1.22e-31 Initial pursuit acceleration; LUSC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg06618935 chr21:46677482 NA -0.39 -7.99 -0.4 2.21e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg02353165 chr6:42928485 GNMT 0.5 6.45 0.33 3.84e-10 Blood protein levels; LUSC cis rs6138458 0.620 rs2151462 chr20:24911823 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.1 0.7 1.58e-51 Blood protein levels; LUSC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -5.94 -0.31 7.02e-9 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg25036284 chr2:26402008 FAM59B 0.67 8.03 0.4 1.72e-14 Gut microbiome composition (summer); LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg08859206 chr1:53392774 SCP2 -0.54 -9.61 -0.47 1.89e-19 Monocyte count; LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs760794 0.765 rs7759616 chr6:19794585 G/A cg02404759 chr6:19790362 NA -0.4 -6.37 -0.33 6.13e-10 Endometriosis; LUSC cis rs763121 0.815 rs4821799 chr22:39021326 T/G cg06544989 chr22:39130855 UNC84B 0.32 5.87 0.31 1.08e-8 Menopause (age at onset); LUSC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg11494091 chr17:61959527 GH2 0.4 6.85 0.35 3.62e-11 Height; LUSC cis rs7107174 0.901 rs2450140 chr11:77924388 T/C cg02023728 chr11:77925099 USP35 0.49 6.78 0.35 5.48e-11 Testicular germ cell tumor; LUSC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg23711669 chr6:146136114 FBXO30 -0.79 -13.87 -0.6 7.57e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.693 rs2339487 chr1:152983528 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.43 -0.38 9.1e-13 Inflammatory skin disease; LUSC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7707921 1.000 rs79616997 chr5:81504600 G/T cg15871215 chr5:81402204 ATG10 -0.45 -6.62 -0.34 1.47e-10 Breast cancer; LUSC cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg25319279 chr11:5960081 NA -0.46 -6.51 -0.34 2.74e-10 DNA methylation (variation); LUSC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg15448220 chr1:150897856 SETDB1 0.42 6.06 0.31 3.68e-9 Melanoma; LUSC cis rs754466 0.580 rs17516020 chr10:79538734 C/T cg17075019 chr10:79541650 NA -0.69 -9.74 -0.47 6.72e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2262909 0.962 rs12609368 chr19:22263996 T/C cg11619707 chr19:22235551 ZNF257 0.39 5.84 0.3 1.25e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs477692 0.663 rs491929 chr10:131368111 G/A cg26102564 chr10:131424627 MGMT 0.41 6.05 0.31 3.88e-9 Response to temozolomide; LUSC cis rs11758351 0.925 rs10452600 chr6:26192502 C/A cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg18904891 chr8:8559673 CLDN23 0.61 8.45 0.42 9.12e-16 Obesity-related traits; LUSC cis rs7575217 0.767 rs28371411 chr2:101754723 C/T cg23907051 chr2:101730305 TBC1D8 -0.28 -7.33 -0.37 1.8e-12 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg09796270 chr17:17721594 SREBF1 -0.43 -7.76 -0.39 1.02e-13 Total body bone mineral density; LUSC cis rs7809950 1.000 rs2712189 chr7:107195747 G/A cg23024343 chr7:107201750 COG5 -0.56 -8.87 -0.44 4.54e-17 Coronary artery disease; LUSC cis rs13064411 0.735 rs6438157 chr3:113207316 G/T cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs11098499 0.691 rs10028773 chr4:120265259 C/G cg24375607 chr4:120327624 NA -0.67 -10.29 -0.49 9.22e-22 Corneal astigmatism; LUSC cis rs887829 0.570 rs13015720 chr2:234600999 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.3 -0.33 9.47e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs7085104 0.700 rs3740397 chr10:104592675 G/C cg15744005 chr10:104629667 AS3MT -0.36 -7.42 -0.38 9.87e-13 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.58 -9.19 -0.45 4.45e-18 Lymphocyte counts; LUSC trans rs722208 0.724 rs7757956 chr6:152317140 T/A cg01002891 chr10:82363434 SH2D4B 0.48 5.95 0.31 6.75e-9 Developmental language disorder; LUSC cis rs3809566 0.526 rs35829897 chr15:63334688 G/C cg05507819 chr15:63340323 TPM1 -0.97 -12.62 -0.57 4.12e-30 Platelet count; LUSC cis rs1865760 0.713 rs9461229 chr6:25992279 G/T cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.08e-11 Height; LUSC cis rs367615 0.512 rs814153 chr5:108667829 A/C cg17395555 chr5:108820864 NA 0.56 9.71 0.47 8.57e-20 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg24558204 chr6:135376177 HBS1L 0.66 10.19 0.49 2.06e-21 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg07507251 chr3:52567010 NT5DC2 0.36 6.91 0.35 2.39e-11 Bipolar disorder; LUSC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs68170813 0.523 rs111590023 chr7:107055323 T/C cg02696742 chr7:106810147 HBP1 -0.62 -9.05 -0.44 1.24e-17 Coronary artery disease; LUSC trans rs6952808 0.717 rs6967442 chr7:1926090 A/G cg04565464 chr8:145669602 NFKBIL2 0.37 6.1 0.32 2.96e-9 Bipolar disorder and schizophrenia; LUSC cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg06060754 chr5:176797920 RGS14 0.59 9.45 0.46 6.37e-19 Hemoglobin concentration;Hematocrit; LUSC cis rs295140 1.000 rs67190025 chr2:201172086 C/T cg04283868 chr2:201171347 SPATS2L 0.44 6.63 0.34 1.36e-10 QT interval; LUSC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg22875332 chr1:76189707 ACADM 0.8 11.7 0.54 9.87e-27 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs372883 0.532 rs388707 chr21:30714776 T/C cg24692254 chr21:30365293 RNF160 -0.55 -7.94 -0.4 3.18e-14 Pancreatic cancer; LUSC cis rs1865721 0.771 rs7228890 chr18:73137492 C/A cg26385618 chr18:73139727 C18orf62 -0.54 -9.91 -0.48 1.84e-20 Intelligence; LUSC cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs394563 0.591 rs237026 chr6:149720681 G/A cg03678062 chr6:149772716 ZC3H12D -0.31 -6.32 -0.33 8.27e-10 Dupuytren's disease; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg23034840 chr1:205782522 SLC41A1 0.59 8.28 0.41 2.93e-15 Menarche (age at onset); LUSC cis rs72781680 0.898 rs72780191 chr2:24007122 T/C cg08917208 chr2:24149416 ATAD2B 0.96 9.92 0.48 1.69e-20 Lymphocyte counts; LUSC trans rs7586604 0.748 rs7578433 chr2:100384141 T/C cg26466323 chr19:19729535 PBX4 -0.86 -6.05 -0.31 3.9e-9 Cannabis dependence symptom count; LUSC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg06074448 chr4:187884817 NA -0.38 -6.41 -0.33 4.99e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.648 rs2002047 chr4:120257228 A/G cg24375607 chr4:120327624 NA 0.77 12.51 0.56 1.08e-29 Corneal astigmatism; LUSC cis rs28785552 0.769 rs11669363 chr19:53232321 C/A cg10871876 chr19:53194124 ZNF83 0.55 8.52 0.42 5.59e-16 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs3087591 1.000 rs6505234 chr17:29688299 G/A cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.78 -0.39 8.96e-14 Hip circumference; LUSC trans rs2243480 1.000 rs781156 chr7:65479141 C/A cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.59e-15 Diabetic kidney disease; LUSC cis rs1371867 0.875 rs1788184 chr8:101335106 A/G cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.37e-11 Atrioventricular conduction; LUSC cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg12219531 chr12:120966889 COQ5 0.62 8.31 0.41 2.42e-15 High light scatter reticulocyte count; LUSC cis rs9517313 0.770 rs9517301 chr13:99095088 A/G cg07423050 chr13:99094983 FARP1 -0.66 -14.98 -0.63 3.5e-39 Neuroticism; LUSC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg17986701 chr20:44574422 PCIF1 0.37 6.63 0.34 1.35e-10 Intelligence (multi-trait analysis); LUSC cis rs73206853 0.563 rs73194047 chr12:111191926 G/A cg12870014 chr12:110450643 ANKRD13A 0.66 6.91 0.35 2.49e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs13089785 1.000 rs34159794 chr3:123645893 A/G cg02012769 chr3:123398346 MYLK 0.31 5.72 0.3 2.35e-8 Intelligence (multi-trait analysis); LUSC cis rs4919687 0.550 rs4264100 chr10:104454113 C/G cg05855489 chr10:104503620 C10orf26 0.7 11.37 0.53 1.58e-25 Colorectal cancer; LUSC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg26597838 chr10:835615 NA 0.78 9.46 0.46 5.75e-19 Eosinophil percentage of granulocytes; LUSC cis rs6782228 0.606 rs2811489 chr3:128337371 A/G cg16766828 chr3:128327626 NA 0.32 5.78 0.3 1.69e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg27121462 chr16:89883253 FANCA 0.59 9.42 0.46 7.52e-19 Vitiligo; LUSC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs9549260 0.755 rs9549244 chr13:41218685 C/T cg21288729 chr13:41239152 FOXO1 0.63 9.59 0.46 2.05e-19 Red blood cell count; LUSC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg15839431 chr19:19639596 YJEFN3 0.44 6.1 0.32 2.87e-9 Tonsillectomy; LUSC cis rs7927771 0.507 rs10838759 chr11:47785347 T/C cg20307385 chr11:47447363 PSMC3 0.44 6.47 0.33 3.4e-10 Subjective well-being; LUSC cis rs13088645 0.729 rs7620040 chr3:134163082 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.52 -7.49 -0.38 6.02e-13 Coronary artery disease; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg02136620 chr5:178986620 RUFY1 0.39 6.02 0.31 4.5e-9 Lung cancer; LUSC cis rs950776 0.518 rs3813572 chr15:78832588 T/C cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs5758659 1.000 rs5758660 chr22:42623718 C/A cg05082376 chr22:42548792 NA -0.4 -6.69 -0.34 9.34e-11 Cognitive function; LUSC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg06558623 chr16:89946397 TCF25 1.11 9.73 0.47 7.08e-20 Skin colour saturation; LUSC cis rs9638182 0.560 rs66506038 chr7:72995943 T/C cg07452164 chr7:72993570 TBL2 0.45 6.33 0.33 7.79e-10 Triglycerides; LUSC cis rs2859741 0.528 rs6686296 chr1:37489380 G/T cg09363841 chr1:37513479 NA 0.4 7.85 0.39 5.9e-14 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs4666002 0.564 rs13030345 chr2:28003174 A/C cg27432699 chr2:27873401 GPN1 -0.48 -5.73 -0.3 2.26e-8 Phospholipid levels (plasma); LUSC cis rs250677 1.000 rs250676 chr5:148425518 A/T cg05026186 chr5:148520876 ABLIM3 -0.37 -6.03 -0.31 4.41e-9 Breast cancer; LUSC cis rs4911259 0.593 rs6058924 chr20:31464467 G/A cg13636640 chr20:31349939 DNMT3B -0.81 -15.5 -0.65 3.33e-41 Inflammatory bowel disease; LUSC cis rs2404602 0.716 rs2404736 chr15:76875943 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.8 -0.39 7.96e-14 Blood metabolite levels; LUSC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.89 0.48 2.12e-20 Major depressive disorder; LUSC cis rs3126085 0.935 rs1390485 chr1:152182168 C/T cg26876637 chr1:152193138 HRNR -0.41 -5.77 -0.3 1.84e-8 Atopic dermatitis; LUSC cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg05043794 chr9:111880884 C9orf5 -0.33 -6.93 -0.35 2.21e-11 Menarche (age at onset); LUSC cis rs4595586 0.545 rs12819061 chr12:39386976 C/T cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg16145915 chr7:1198662 ZFAND2A -0.74 -15.77 -0.65 3.01e-42 Longevity;Endometriosis; LUSC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg04450456 chr4:17643702 FAM184B 0.42 7.19 0.37 4.19e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7943203 0.568 rs61913891 chr11:108335075 A/G cg04873221 chr11:107992290 ACAT1 -0.39 -5.79 -0.3 1.63e-8 Red blood cell count;Mean corpuscular volume; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg16944820 chr13:45492071 NA 0.46 6.04 0.31 4.07e-9 Neuroticism; LUSC cis rs17270561 0.609 rs4711100 chr6:25741954 G/A cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs9326248 0.861 rs1871757 chr11:117030581 A/T cg11861562 chr11:117069780 TAGLN 0.36 5.91 0.31 8.66e-9 Blood protein levels; LUSC cis rs2455601 0.608 rs59025804 chr11:8870301 T/C cg12365402 chr11:9010492 NRIP3 -0.37 -5.86 -0.31 1.12e-8 Schizophrenia; LUSC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.48 0.33 3.28e-10 Lung cancer; LUSC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.59 0.38 3.18e-13 Vitiligo; LUSC cis rs4363385 0.818 rs6587719 chr1:152993409 G/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.79 -0.3 1.63e-8 Inflammatory skin disease; LUSC cis rs11098499 0.691 rs9996644 chr4:120238877 G/T cg09307838 chr4:120376055 NA 0.7 10.41 0.5 3.52e-22 Corneal astigmatism; LUSC trans rs12579753 1.000 rs10862372 chr12:82249804 C/T cg07923666 chr12:49932857 KCNH3 -0.54 -6.67 -0.34 1.05e-10 Resting heart rate; LUSC trans rs1814175 0.817 rs12290508 chr11:49621037 C/T cg03929089 chr4:120376271 NA -1.01 -18.94 -0.72 7.37e-55 Height; LUSC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg17376030 chr22:41985996 PMM1 0.45 5.77 0.3 1.77e-8 Vitiligo; LUSC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg09365446 chr1:150670422 GOLPH3L 0.49 7.23 0.37 3.36e-12 Melanoma; LUSC cis rs7824557 0.843 rs2736375 chr8:11115749 C/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.21 -0.32 1.57e-9 Retinal vascular caliber; LUSC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg25767906 chr1:53392781 SCP2 -0.36 -6.18 -0.32 1.88e-9 Monocyte count; LUSC cis rs12912251 1.000 rs34356257 chr15:38989605 T/C cg01338139 chr15:38987640 C15orf53 -0.51 -7.11 -0.36 7.04e-12 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs9309473 1.000 rs1534471 chr2:73647508 G/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.33 -0.33 7.93e-10 Metabolite levels; LUSC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg12310025 chr6:25882481 NA -0.47 -7.89 -0.4 4.25e-14 Intelligence (multi-trait analysis); LUSC cis rs4319547 0.656 rs2173582 chr12:122824694 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.35 -0.42 1.79e-15 Body mass index; LUSC cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -7.46 -0.38 7.48e-13 Menarche (age at onset); LUSC cis rs72781680 0.898 rs72786276 chr2:24062566 G/A cg20701182 chr2:24300061 SF3B14 0.73 7.42 0.38 9.58e-13 Lymphocyte counts; LUSC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.81 12.31 0.56 5.87e-29 Cognitive test performance; LUSC cis rs12908161 1.000 rs11632465 chr15:85282045 A/T cg12863693 chr15:85201151 NMB 0.41 8.61 0.43 2.99e-16 Schizophrenia; LUSC cis rs2730245 0.527 rs62476464 chr7:158698063 C/T cg11984989 chr7:158649758 WDR60 1.13 13.48 0.59 2.25e-33 Height; LUSC cis rs7481584 0.603 rs399467 chr11:3072348 G/A cg08508325 chr11:3079039 CARS 0.38 8.58 0.42 3.75e-16 Calcium levels; LUSC cis rs9611565 0.605 rs202638 chr22:41855458 A/G cg03806693 chr22:41940476 POLR3H 0.86 12.23 0.56 1.15e-28 Vitiligo; LUSC cis rs734999 0.967 rs10752745 chr1:2507938 A/G cg18854424 chr1:2615690 NA 0.46 9.59 0.46 2.09e-19 Ulcerative colitis; LUSC cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg03433033 chr1:76189801 ACADM -0.48 -7.27 -0.37 2.63e-12 Daytime sleep phenotypes; LUSC cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg13256891 chr4:100009986 ADH5 -0.45 -6.16 -0.32 2.05e-9 Alcohol dependence; LUSC trans rs236907 0.679 rs12750330 chr1:171803556 G/A cg13482142 chr2:234261155 NA 0.52 6.29 0.33 9.75e-10 Mean platelet volume; LUSC cis rs500891 0.574 rs12197649 chr6:84123548 C/T cg08257003 chr6:84140564 ME1 0.34 7.72 0.39 1.4e-13 Platelet-derived growth factor BB levels; LUSC cis rs9326248 0.861 rs4938343 chr11:117003528 G/C cg26566898 chr11:117069891 TAGLN 0.4 6.17 0.32 1.99e-9 Blood protein levels; LUSC cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg19875535 chr5:140030758 IK -0.54 -8.71 -0.43 1.43e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg16405210 chr4:1374714 KIAA1530 -0.57 -8.8 -0.43 7.35e-17 Obesity-related traits; LUSC cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg05347473 chr6:146136440 FBXO30 0.48 7.81 0.39 7.56e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs9303542 0.559 rs35621842 chr17:46606222 C/T cg09704116 chr17:46666958 LOC404266 -0.39 -6.97 -0.36 1.75e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC trans rs11722228 0.508 rs3756227 chr4:10087995 C/A cg26043149 chr18:55253948 FECH 0.94 14.09 0.61 1.08e-35 Gout;Urate levels;Serum uric acid levels; LUSC cis rs6545883 0.791 rs4672445 chr2:61655008 T/C cg15711740 chr2:61764176 XPO1 0.45 6.94 0.36 2.04e-11 Tuberculosis; LUSC cis rs11190604 1.000 rs11816840 chr10:102309220 G/C cg23241863 chr10:102295624 HIF1AN 0.48 5.78 0.3 1.68e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.17 0.52 7.73e-25 Prudent dietary pattern; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.87 0.54 2.36e-27 Prudent dietary pattern; LUSC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg11812906 chr14:75593930 NEK9 -0.63 -10.35 -0.49 5.99e-22 Height; LUSC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg16584290 chr5:462447 EXOC3 -0.37 -6.38 -0.33 5.96e-10 Cystic fibrosis severity; LUSC cis rs9612 1.000 rs1059 chr19:44268348 C/T cg08581076 chr19:44259116 C19orf61 0.49 5.94 0.31 7.29e-9 Exhaled nitric oxide output; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg11843238 chr5:131593191 PDLIM4 -0.37 -6.26 -0.32 1.17e-9 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21875080 chr1:46598774 PIK3R3 -0.38 -6.0 -0.31 5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg15117754 chr3:10150083 C3orf24 0.44 5.66 0.3 3.32e-8 Alzheimer's disease; LUSC trans rs1908814 0.516 rs58869268 chr8:11797095 G/C cg08975724 chr8:8085496 FLJ10661 0.47 6.73 0.35 7.34e-11 Neuroticism; LUSC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg26566898 chr11:117069891 TAGLN -0.32 -6.11 -0.32 2.84e-9 Blood protein levels; LUSC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.62 -13.21 -0.59 2.42e-32 Monocyte percentage of white cells; LUSC cis rs72781680 0.528 rs56258075 chr2:24104256 C/G cg20701182 chr2:24300061 SF3B14 0.54 5.8 0.3 1.56e-8 Lymphocyte counts; LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg10729496 chr3:10149963 C3orf24 -0.55 -7.54 -0.38 4.42e-13 Alzheimer's disease; LUSC cis rs8060686 0.545 rs12600062 chr16:68287544 C/A cg05110241 chr16:68378359 PRMT7 -0.71 -7.36 -0.37 1.42e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs11190604 1.000 rs3750719 chr10:102248950 C/G cg16342193 chr10:102329863 NA -0.37 -6.49 -0.33 3.16e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -6.44 -0.33 4.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs2072499 0.833 rs2842873 chr1:156204653 C/T cg25208724 chr1:156163844 SLC25A44 1.03 22.67 0.78 1.45e-69 Testicular germ cell tumor; LUSC cis rs9399135 0.967 rs9376085 chr6:135371224 T/C cg22676075 chr6:135203613 NA 0.47 7.27 0.37 2.62e-12 Red blood cell count; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg04703749 chr11:64809102 SAC3D1 0.51 6.47 0.33 3.45e-10 Cognitive function;Information processing speed; LUSC cis rs9535307 0.929 rs9526593 chr13:50288777 T/C cg04663916 chr13:50265991 EBPL 0.49 5.71 0.3 2.44e-8 Obesity-related traits; LUSC cis rs3931020 0.508 rs2345436 chr1:75198740 A/C cg00121533 chr1:75199117 CRYZ;TYW3 0.42 5.72 0.3 2.34e-8 Resistin levels; LUSC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg18230493 chr5:56204884 C5orf35 -0.85 -13.2 -0.59 2.74e-32 Initial pursuit acceleration; LUSC trans rs7710178 0.652 rs2656894 chr5:155949781 G/C cg00803088 chr10:43600706 RET -0.48 -6.05 -0.31 3.88e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs7818345 0.935 rs7016259 chr8:19277530 A/G cg11303988 chr8:19266685 CSGALNACT1 0.39 7.42 0.38 9.75e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7605827 0.930 rs7568459 chr2:15691026 C/T cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.93e-21 Morning vs. evening chronotype; LUSC cis rs11676348 0.791 rs4133195 chr2:218951245 A/G cg00012203 chr2:219082015 ARPC2 0.55 8.83 0.43 6.09e-17 Ulcerative colitis; LUSC cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg12935359 chr14:103987150 CKB -0.52 -8.1 -0.41 1.02e-14 Body mass index; LUSC cis rs72781680 0.752 rs7578606 chr2:23902360 T/C cg20701182 chr2:24300061 SF3B14 0.73 7.06 0.36 9.63e-12 Lymphocyte counts; LUSC cis rs7568458 0.870 rs1562323 chr2:85809711 T/C cg02493740 chr2:85810744 VAMP5 -0.33 -5.83 -0.3 1.34e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11168618 0.904 rs4359253 chr12:48927708 G/A cg24011408 chr12:48396354 COL2A1 0.39 6.27 0.32 1.1e-9 Adiponectin levels; LUSC cis rs637571 0.726 rs526631 chr11:65681965 T/G cg26695010 chr11:65641043 EFEMP2 0.5 7.21 0.37 3.73e-12 Eosinophil percentage of white cells; LUSC cis rs1801251 0.963 rs13021246 chr2:233623111 T/C cg08000102 chr2:233561755 GIGYF2 0.69 11.59 0.54 2.57e-26 Coronary artery disease; LUSC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg17971929 chr21:40555470 PSMG1 -0.61 -9.78 -0.47 5.09e-20 Cognitive function; LUSC cis rs3126085 0.825 rs11204933 chr1:152172185 C/T cg26876637 chr1:152193138 HRNR 0.45 6.44 0.33 4.15e-10 Atopic dermatitis; LUSC trans rs330071 0.549 rs11785593 chr8:9256324 A/G cg06636001 chr8:8085503 FLJ10661 0.45 6.22 0.32 1.47e-9 Acne (severe); LUSC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg24531977 chr5:56204891 C5orf35 -0.72 -10.46 -0.5 2.37e-22 Coronary artery disease; LUSC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg04369109 chr6:150039330 LATS1 -0.53 -7.86 -0.39 5.51e-14 Lung cancer; LUSC cis rs877282 0.898 rs11253340 chr10:764786 G/T cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC cis rs7589342 0.839 rs7589790 chr2:106433909 C/G cg14210321 chr2:106509881 NCK2 0.44 6.32 0.33 8.24e-10 Addiction; LUSC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs67478160 0.584 rs2295148 chr14:104195610 T/C cg01849466 chr14:104193079 ZFYVE21 -0.63 -10.72 -0.51 2.98e-23 Schizophrenia; LUSC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11890956 chr21:40555474 PSMG1 -0.75 -11.65 -0.54 1.47e-26 Menarche (age at onset); LUSC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.81 0.51 1.51e-23 Monocyte percentage of white cells; LUSC cis rs477692 0.905 rs485579 chr10:131425492 T/G cg11019008 chr10:131425282 MGMT 0.42 6.39 0.33 5.57e-10 Response to temozolomide; LUSC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg14541582 chr5:601475 NA -0.38 -5.93 -0.31 7.36e-9 Lung disease severity in cystic fibrosis; LUSC cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg00750074 chr16:89608354 SPG7 0.45 7.65 0.39 2.21e-13 Multiple myeloma (IgH translocation); LUSC cis rs9486719 1.000 rs11152969 chr6:96908712 A/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs12295403 0.691 rs9705036 chr11:18686916 A/G cg20219074 chr11:18656078 SPTY2D1 -0.41 -5.83 -0.3 1.34e-8 Ovarian reserve; LUSC cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg21573476 chr21:45109991 RRP1B -0.38 -6.08 -0.32 3.37e-9 Mean corpuscular volume; LUSC cis rs6060717 0.536 rs3787173 chr20:34472105 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.69 -0.3 2.73e-8 Hip circumference adjusted for BMI; LUSC cis rs73200209 0.744 rs73200226 chr12:116637861 G/A cg01776926 chr12:116560359 MED13L -0.49 -6.02 -0.31 4.47e-9 Total body bone mineral density; LUSC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.7 10.47 0.5 2.28e-22 IgG glycosylation; LUSC cis rs4073582 0.595 rs801741 chr11:65917084 A/G cg14036092 chr11:66035641 RAB1B 0.42 6.04 0.31 4.2e-9 Gout; LUSC cis rs7000551 0.681 rs2461488 chr8:22371858 G/A cg12081754 chr8:22256438 SLC39A14 0.43 6.51 0.34 2.72e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9788682 0.747 rs28511883 chr15:78783683 C/T cg18825076 chr15:78729989 IREB2 0.44 6.06 0.31 3.7e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7799006 0.755 rs2256545 chr7:2291943 G/A cg02951883 chr7:2050386 MAD1L1 -0.38 -6.27 -0.32 1.12e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg06634786 chr22:41940651 POLR3H 0.52 6.07 0.32 3.53e-9 Vitiligo; LUSC cis rs62103177 0.564 rs3930043 chr18:77723832 G/A cg20368463 chr18:77673604 PQLC1 0.73 7.46 0.38 7.45e-13 Opioid sensitivity; LUSC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg22496380 chr5:211416 CCDC127 -0.74 -8.57 -0.42 3.87e-16 Breast cancer; LUSC cis rs11971779 0.590 rs6944104 chr7:139051120 T/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg00166722 chr3:10149974 C3orf24 0.62 8.47 0.42 8.07e-16 Alzheimer's disease; LUSC trans rs13394458 0.643 rs116576020 chr2:142225421 A/T cg22060041 chr2:1796155 MYT1L 0.45 6.23 0.32 1.41e-9 Night sleep phenotypes; LUSC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.18 0.52 7.4e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg12419862 chr22:24373484 LOC391322 -0.82 -12.36 -0.56 3.57e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10072221 0.836 rs6895725 chr5:75696657 A/G cg03132911 chr5:75698732 IQGAP2 0.39 6.5 0.34 2.92e-10 Mean platelet volume; LUSC cis rs16949788 1.000 rs11071894 chr15:66773733 A/C cg08120210 chr15:66682733 MAP2K1 0.55 5.8 0.3 1.57e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs829883 0.724 rs3168521 chr12:98908547 C/T cg25150519 chr12:98850993 NA -0.64 -8.67 -0.43 1.94e-16 Colorectal adenoma (advanced); LUSC trans rs6502050 0.769 rs9904237 chr17:80119664 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.72e-10 Life satisfaction; LUSC cis rs273573 0.925 rs273569 chr11:30914035 G/A cg14844989 chr11:31128820 NA 0.35 5.68 0.3 2.98e-8 Total body bone mineral density; LUSC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg24209194 chr3:40518798 ZNF619 0.47 6.51 0.34 2.75e-10 Renal cell carcinoma; LUSC cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg24675658 chr1:53192096 ZYG11B 0.73 12.2 0.56 1.44e-28 Monocyte count; LUSC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.67 -0.39 1.9e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs2235649 0.833 rs4335769 chr16:1849376 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.06 -0.31 3.74e-9 Blood metabolite levels; LUSC cis rs2288073 0.965 rs13395596 chr2:24410738 T/C cg06627628 chr2:24431161 ITSN2 -0.74 -10.35 -0.49 5.96e-22 Venous thromboembolism (SNP x SNP interaction); LUSC trans rs1922233 1.000 rs2204874 chr4:92367486 A/G cg24250684 chr1:219729030 NA -0.36 -6.37 -0.33 6.33e-10 Gut microbiome composition (summer and winter); LUSC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg06713675 chr4:122721982 EXOSC9 -0.46 -8.07 -0.4 1.27e-14 Type 2 diabetes; LUSC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg03233332 chr7:66118400 NA 0.42 6.09 0.32 3.02e-9 Aortic root size; LUSC cis rs3126085 0.935 rs1496051 chr1:152164923 G/A cg26876637 chr1:152193138 HRNR 0.47 6.62 0.34 1.47e-10 Atopic dermatitis; LUSC cis rs7799006 0.929 rs6951493 chr7:2257612 G/A cg02951883 chr7:2050386 MAD1L1 -0.36 -6.14 -0.32 2.36e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.86 -0.54 2.49e-27 Extrinsic epigenetic age acceleration; LUSC cis rs4704187 0.687 rs9763362 chr5:74406316 T/C cg03227963 chr5:74354835 NA 0.32 6.87 0.35 3.09e-11 Response to amphetamines; LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg00149659 chr3:10157352 C3orf10 -1.02 -13.7 -0.6 3.18e-34 Alzheimer's disease; LUSC cis rs9646954 0.542 rs4149505 chr2:101033697 G/A cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs2688608 0.620 rs7098444 chr10:75580042 C/T cg17411546 chr10:75410026 SYNPO2L -0.53 -7.81 -0.39 7.29e-14 Inflammatory bowel disease; LUSC cis rs11051970 0.918 rs7309115 chr12:32541241 A/G cg02745156 chr12:32552066 NA 0.44 6.92 0.35 2.36e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg11812906 chr14:75593930 NEK9 0.66 11.39 0.53 1.26e-25 Height; LUSC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg06108461 chr20:60628389 TAF4 -0.97 -16.53 -0.67 2.89e-45 Body mass index; LUSC trans rs12310956 0.532 rs7979535 chr12:33947450 A/C cg26384229 chr12:38710491 ALG10B -0.72 -11.69 -0.54 1.03e-26 Morning vs. evening chronotype; LUSC cis rs17102423 0.594 rs2781373 chr14:65568215 G/A cg11161011 chr14:65562177 MAX -0.71 -10.82 -0.51 1.37e-23 Obesity-related traits; LUSC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg06238570 chr21:40685208 BRWD1 0.46 7.14 0.36 5.73e-12 Cognitive function; LUSC cis rs977987 0.843 rs10871312 chr16:75486202 C/T cg03315344 chr16:75512273 CHST6 0.49 9.41 0.46 8.39e-19 Dupuytren's disease; LUSC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg17971929 chr21:40555470 PSMG1 0.76 12.75 0.57 1.29e-30 Cognitive function; LUSC cis rs9815354 0.680 rs73073263 chr3:42018666 C/A cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs9677476 0.863 rs60953838 chr2:232065864 G/C cg07929768 chr2:232055508 NA 0.36 6.79 0.35 5.22e-11 Food antigen IgG levels; LUSC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg14343924 chr8:8086146 FLJ10661 0.42 6.11 0.32 2.77e-9 Mood instability; LUSC cis rs10792830 0.714 rs501505 chr11:85667916 C/A cg07180834 chr11:85838833 NA -0.3 -5.77 -0.3 1.79e-8 Psychosis and Alzheimer's disease; LUSC cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14442939 chr10:27389572 ANKRD26 -0.88 -9.9 -0.48 1.97e-20 Breast cancer; LUSC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.37 -0.33 6.35e-10 Major depressive disorder; LUSC cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.86 -0.35 3.4e-11 Monocyte percentage of white cells; LUSC cis rs1322512 0.874 rs1727048 chr6:152942842 A/G cg27316956 chr6:152958899 SYNE1 -0.35 -5.8 -0.3 1.54e-8 Tonometry; LUSC cis rs3806843 0.966 rs4141841 chr5:140203432 C/T cg19875535 chr5:140030758 IK 0.51 8.25 0.41 3.64e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs2742417 0.603 rs2064064 chr3:45759995 C/T cg04837898 chr3:45731254 SACM1L -0.44 -7.19 -0.37 4.38e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg01475377 chr6:109611718 NA -0.4 -7.0 -0.36 1.44e-11 Reticulocyte fraction of red cells; LUSC cis rs2370759 1.000 rs2370759 chr10:32634972 G/A cg01819863 chr10:32635814 EPC1 1.05 12.84 0.57 6.06e-31 Sexual dysfunction (female); LUSC cis rs11122272 0.735 rs2491412 chr1:231535880 A/T cg06096015 chr1:231504339 EGLN1 0.56 10.02 0.48 7.84e-21 Hemoglobin concentration; LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg08067268 chr2:26466485 HADHB;HADHA 0.52 7.23 0.37 3.27e-12 Mean corpuscular hemoglobin; LUSC cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs7178375 1.000 rs35162264 chr15:31200683 T/A cg04373760 chr16:53404718 NA 0.65 8.72 0.43 1.36e-16 Hypertriglyceridemia; LUSC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg03433033 chr1:76189801 ACADM 0.84 15.31 0.64 1.93e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9650657 0.615 rs12541110 chr8:10695125 A/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.25 -0.32 1.28e-9 Neuroticism; LUSC cis rs7577696 0.513 rs212685 chr2:32434701 A/G cg02381751 chr2:32503542 YIPF4 0.53 7.08 0.36 8.5e-12 Inflammatory biomarkers; LUSC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg06108461 chr20:60628389 TAF4 -0.76 -12.69 -0.57 2.29e-30 Body mass index; LUSC cis rs3755132 0.929 rs4668942 chr2:15750443 A/G cg12888861 chr2:15731646 DDX1 0.5 7.51 0.38 5.48e-13 Wilms tumor; LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg09877947 chr5:131593287 PDLIM4 0.49 8.04 0.4 1.52e-14 Blood metabolite levels; LUSC cis rs9486715 0.867 rs9373887 chr6:96957004 C/T cg06623918 chr6:96969491 KIAA0776 0.94 17.41 0.69 9.46e-49 Headache; LUSC cis rs12579753 1.000 rs7956826 chr12:82173365 A/G cg21231944 chr12:82153410 PPFIA2 -0.4 -6.05 -0.31 3.81e-9 Resting heart rate; LUSC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg05802129 chr4:122689817 NA -0.37 -6.56 -0.34 2.06e-10 Type 2 diabetes; LUSC cis rs12681287 0.640 rs72606633 chr8:87476236 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.16 -0.36 5.04e-12 Caudate activity during reward; LUSC cis rs722599 0.639 rs12882676 chr14:75272433 A/G cg08847533 chr14:75593920 NEK9 0.44 6.15 0.32 2.23e-9 IgG glycosylation; LUSC cis rs7508679 1.000 rs10401485 chr19:7222234 T/C cg00428638 chr19:7224713 INSR 0.36 7.74 0.39 1.21e-13 Hypothyroidism; LUSC cis rs11209185 0.509 rs12130147 chr1:68446944 G/A cg22082780 chr1:68452167 NA 0.44 7.26 0.37 2.7e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg07424592 chr7:64974309 NA 0.7 6.15 0.32 2.24e-9 Diabetic kidney disease; LUSC cis rs6121246 0.909 rs6060870 chr20:30303299 C/T cg13852791 chr20:30311386 BCL2L1 0.87 11.78 0.54 5.24e-27 Mean corpuscular hemoglobin; LUSC cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg17691542 chr6:26056736 HIST1H1C 0.47 6.93 0.35 2.18e-11 Height; LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.78 0.63 2.13e-38 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25289973 chr4:41362397 LIMCH1 0.41 6.11 0.32 2.72e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.76 0.35 6.34e-11 Tonsillectomy; LUSC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.78 -0.3 1.75e-8 Tonsillectomy; LUSC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg05425664 chr17:57184151 TRIM37 -0.52 -7.74 -0.39 1.2e-13 Intelligence (multi-trait analysis); LUSC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.56e-11 Total body bone mineral density; LUSC cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg23992470 chr4:843637 GAK 0.61 6.52 0.34 2.55e-10 Intelligence (multi-trait analysis); LUSC cis rs2046867 0.818 rs17010195 chr3:72872852 A/G cg25664220 chr3:72788482 NA 0.56 10.72 0.51 3.16e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs113835537 0.529 rs75683511 chr11:66275026 A/G cg24851651 chr11:66362959 CCS 0.52 7.55 0.38 4.16e-13 Airway imaging phenotypes; LUSC cis rs11785693 0.862 rs11781233 chr8:4993653 C/G cg26367366 chr8:4980734 NA -0.74 -8.97 -0.44 2.23e-17 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg24846343 chr22:24311635 DDTL 0.76 16.98 0.68 4.84e-47 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4930103 0.591 rs11042048 chr11:1986240 C/G cg06197492 chr11:2016605 H19 0.43 7.0 0.36 1.42e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg01097406 chr16:89675127 NA 0.48 9.88 0.48 2.31e-20 Vitiligo; LUSC trans rs11039798 1.000 rs10769370 chr11:48515430 A/G cg15704280 chr7:45808275 SEPT13 0.72 6.8 0.35 4.71e-11 Axial length; LUSC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg26769984 chr7:1090371 C7orf50 0.55 7.44 0.38 8.76e-13 Bronchopulmonary dysplasia; LUSC cis rs6494488 0.500 rs951721 chr15:65044435 C/T cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg10792982 chr14:105748885 BRF1 0.48 8.7 0.43 1.52e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg01879757 chr17:41196368 BRCA1 -0.45 -6.99 -0.36 1.54e-11 Menopause (age at onset); LUSC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg10356904 chr22:49881777 NA -0.33 -7.52 -0.38 5.24e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs5771069 0.931 rs137864 chr22:50446988 C/T cg03721641 chr22:50451245 IL17REL 0.28 5.71 0.3 2.56e-8 Ulcerative colitis; LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs4947962 0.590 rs759171 chr7:55086212 A/C cg23757825 chr7:55092271 EGFR 0.65 8.44 0.42 9.59e-16 Subjective response to lithium treatment; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12311644 chr22:31687046 PIK3IP1 0.44 6.03 0.31 4.25e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7818345 0.624 rs12682196 chr8:19332963 A/C cg11303988 chr8:19266685 CSGALNACT1 -0.33 -5.98 -0.31 5.83e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg18252515 chr7:66147081 NA -0.4 -5.72 -0.3 2.32e-8 Aortic root size; LUSC cis rs4919694 0.901 rs113541728 chr10:104716771 A/T cg04362960 chr10:104952993 NT5C2 1.15 13.83 0.6 1.01e-34 Arsenic metabolism; LUSC cis rs7640424 0.659 rs7639774 chr3:107816216 T/G cg09227934 chr3:107805635 CD47 -0.54 -7.83 -0.39 6.71e-14 Body mass index; LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs259282 0.605 rs36107586 chr19:33109674 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.66 9.97 0.48 1.11e-20 Schizophrenia; LUSC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs9814567 1.000 rs9856693 chr3:134306913 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4319547 0.695 rs4758643 chr12:122924819 A/T cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.52 -0.42 5.55e-16 Body mass index; LUSC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg20135002 chr11:47629003 NA -0.48 -7.52 -0.38 5.13e-13 Subjective well-being; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg01577475 chr2:114033581 PAX8;LOC440839 -0.3 -7.5 -0.38 5.75e-13 Lymphocyte counts; LUSC cis rs11098499 0.954 rs10024844 chr4:120311528 A/G cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs981844 0.857 rs72731698 chr4:154716353 T/C cg14289246 chr4:154710475 SFRP2 0.48 6.23 0.32 1.38e-9 Response to statins (LDL cholesterol change); LUSC cis rs394563 0.591 rs6570963 chr6:149691355 T/G cg11245181 chr6:149772854 ZC3H12D 0.29 6.33 0.33 7.8e-10 Dupuytren's disease; LUSC cis rs8017423 0.967 rs7150093 chr14:90724661 C/T cg14092571 chr14:90743983 NA 0.36 5.97 0.31 6.1e-9 Mortality in heart failure; LUSC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.48 0.33 3.32e-10 Menarche (age at onset); LUSC cis rs7258465 1.000 rs10405636 chr19:18538742 A/C cg11102782 chr19:18549136 ISYNA1 -0.36 -6.78 -0.35 5.34e-11 Breast cancer; LUSC cis rs17270561 0.636 rs4360128 chr6:25734558 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg08472276 chr7:1133186 C7orf50;GPER -0.39 -6.34 -0.33 7.64e-10 Longevity;Endometriosis; LUSC trans rs6502050 0.835 rs4247357 chr17:80166989 G/T cg07393940 chr7:158741817 NA 0.36 6.48 0.33 3.19e-10 Life satisfaction; LUSC cis rs1568889 1.000 rs7949057 chr11:28255053 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.33 0.45 1.54e-18 Bipolar disorder; LUSC cis rs7589342 0.745 rs933793 chr2:106511846 C/T cg14210321 chr2:106509881 NCK2 0.59 9.27 0.45 2.42e-18 Addiction; LUSC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg02574844 chr11:5959923 NA -0.43 -6.14 -0.32 2.34e-9 DNA methylation (variation); LUSC cis rs11583043 0.957 rs6577223 chr1:101499750 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.41 5.71 0.3 2.47e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6582630 0.555 rs11181053 chr12:38271364 T/C cg13010199 chr12:38710504 ALG10B -0.49 -7.44 -0.38 8.78e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg02423579 chr7:2872169 GNA12 -0.46 -6.43 -0.33 4.41e-10 Height; LUSC cis rs1801251 1.000 rs13035829 chr2:233604487 A/T cg25237894 chr2:233734115 C2orf82 0.34 6.33 0.33 7.76e-10 Coronary artery disease; LUSC cis rs360798 0.553 rs7562734 chr2:63047973 G/C cg17519650 chr2:63277830 OTX1 -0.51 -7.25 -0.37 2.91e-12 Coronary artery disease; LUSC cis rs2985684 0.789 rs1957979 chr14:50063332 A/G cg04989706 chr14:50066350 PPIL5 -0.48 -6.32 -0.33 8.2e-10 Carotid intima media thickness; LUSC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg09034736 chr1:150693464 HORMAD1 0.42 5.88 0.31 9.72e-9 Melanoma; LUSC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg11062466 chr8:58055876 NA 0.5 6.39 0.33 5.51e-10 Developmental language disorder (linguistic errors); LUSC cis rs11971779 0.680 rs6467837 chr7:139023575 A/G cg23387468 chr7:139079360 LUC7L2 0.42 6.29 0.33 9.94e-10 Diisocyanate-induced asthma; LUSC cis rs4930103 0.935 rs11042167 chr11:2020901 G/A cg06197492 chr11:2016605 H19 0.42 6.87 0.35 3.22e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs12210905 0.688 rs12213533 chr6:27346021 C/T cg08851530 chr6:28072375 NA 0.9 5.84 0.3 1.21e-8 Hip circumference adjusted for BMI; LUSC cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg22709100 chr7:91322751 NA 0.4 5.79 0.3 1.59e-8 Breast cancer; LUSC cis rs12291225 0.877 rs2303974 chr11:14264979 G/T cg05501817 chr11:14380813 RRAS2 -0.43 -6.33 -0.33 7.87e-10 Sense of smell; LUSC cis rs73206853 0.764 rs9737665 chr12:111031847 A/C cg12870014 chr12:110450643 ANKRD13A 0.7 7.81 0.39 7.23e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs3008870 0.959 rs4655658 chr1:67389608 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.94 14.83 0.63 1.39e-38 Lymphocyte percentage of white cells; LUSC cis rs9303401 0.659 rs34913878 chr17:56897094 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.71 0.6 3.09e-34 Cognitive test performance; LUSC cis rs10193935 0.901 rs1496329 chr2:42688797 T/C cg27598129 chr2:42591480 NA 0.62 7.98 0.4 2.33e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs62432291 0.614 rs420339 chr6:159657195 G/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.64e-9 Joint mobility (Beighton score); LUSC cis rs694739 0.726 rs17857342 chr11:64138905 T/G cg02228329 chr11:64053129 BAD;GPR137 0.44 6.21 0.32 1.59e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg26408565 chr15:76604113 ETFA -0.48 -7.49 -0.38 6.4e-13 Blood metabolite levels; LUSC cis rs9486719 0.857 rs9285393 chr6:97020917 C/A cg06623918 chr6:96969491 KIAA0776 -0.76 -10.67 -0.5 4.68e-23 Migraine;Coronary artery disease; LUSC cis rs11622475 1.000 rs2236246 chr14:104379206 A/C cg12183467 chr14:104352244 NA 0.47 8.25 0.41 3.59e-15 Bipolar disorder; LUSC cis rs6500602 0.702 rs2304634 chr16:4500544 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 6.8 0.35 4.82e-11 Schizophrenia; LUSC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg25019033 chr10:957182 NA -0.47 -5.83 -0.3 1.31e-8 Eosinophil percentage of granulocytes; LUSC cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg02527881 chr3:46936655 PTH1R -0.67 -12.21 -0.56 1.34e-28 Birth weight; LUSC cis rs34091558 1 rs34091558 chr1:201886769 TA/T cg10061532 chr1:201886748 LMOD1 0.29 6.63 0.34 1.32e-10 Breast size; LUSC cis rs7584330 0.737 rs11886117 chr2:238361650 A/T cg14458575 chr2:238380390 NA 0.67 11.78 0.54 5.12e-27 Prostate cancer; LUSC cis rs6669072 0.605 rs11586930 chr1:91255296 T/G cg08895590 chr1:91227319 NA -0.28 -6.05 -0.31 3.97e-9 Cognitive function; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.47 0.53 6.83e-26 Alzheimer's disease; LUSC cis rs2204008 0.577 rs2623049 chr12:38018831 G/A cg26384229 chr12:38710491 ALG10B -0.81 -13.48 -0.59 2.33e-33 Bladder cancer; LUSC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg04267008 chr7:1944627 MAD1L1 -0.53 -8.13 -0.41 8.48e-15 Bipolar disorder and schizophrenia; LUSC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg24733560 chr20:60626293 TAF4 0.41 6.7 0.34 8.82e-11 Body mass index; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg25428297 chr7:1022841 CYP2W1 0.28 5.67 0.3 3.01e-8 Longevity;Endometriosis; LUSC cis rs814295 0.932 rs780092 chr2:27743154 A/G cg27432699 chr2:27873401 GPN1 0.48 5.74 0.3 2.16e-8 Triglyceride levels; LUSC trans rs4650994 0.524 rs1998544 chr1:178605276 T/C cg05059571 chr16:84539110 KIAA1609 0.47 8.85 0.44 5.35e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg01475377 chr6:109611718 NA -0.41 -7.4 -0.38 1.15e-12 Reticulocyte fraction of red cells; LUSC trans rs3733585 0.806 rs7375599 chr4:9954918 C/T cg26043149 chr18:55253948 FECH 0.45 7.02 0.36 1.21e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9300255 0.602 rs2682434 chr12:123694724 C/T cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs8027181 0.839 rs998020 chr15:72999635 C/T cg25632853 chr15:73088954 NA 0.32 6.59 0.34 1.68e-10 Triglyceride levels; LUSC cis rs9486715 1.000 rs7752277 chr6:97065131 C/T cg06623918 chr6:96969491 KIAA0776 -0.87 -14.93 -0.63 5.53e-39 Headache; LUSC cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 8.1 0.41 1.04e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs983392 0.679 rs10736700 chr11:60031399 T/C cg02771260 chr11:59836817 MS4A3 0.37 6.08 0.32 3.31e-9 Alzheimer's disease (late onset); LUSC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg06552810 chr11:31128660 NA -0.4 -7.24 -0.37 3.05e-12 Red blood cell count; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg11494091 chr17:61959527 GH2 0.65 13.97 0.61 2.98e-35 Prudent dietary pattern; LUSC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg19774624 chr17:42201019 HDAC5 0.73 10.76 0.51 2.18e-23 Total body bone mineral density; LUSC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg17366294 chr4:99064904 C4orf37 0.54 8.83 0.43 6.14e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs877282 0.583 rs11253429 chr10:823234 A/C cg22713356 chr15:30763199 NA 0.75 9.37 0.46 1.12e-18 Uric acid levels; LUSC cis rs2985684 0.894 rs10147029 chr14:50020232 G/T cg04989706 chr14:50066350 PPIL5 0.47 6.43 0.33 4.29e-10 Carotid intima media thickness; LUSC cis rs72781680 1.000 rs74704838 chr2:24158270 C/A cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs7568458 0.527 rs35416445 chr2:85773659 A/G cg02493740 chr2:85810744 VAMP5 -0.53 -9.26 -0.45 2.59e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1451375 0.959 rs17133878 chr7:50620927 T/C cg18232548 chr7:50535776 DDC 0.51 7.69 0.39 1.65e-13 Malaria; LUSC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg24675658 chr1:53192096 ZYG11B -0.57 -8.73 -0.43 1.25e-16 Monocyte count; LUSC cis rs8099014 1.000 rs7234602 chr18:56111593 G/T cg12907477 chr18:56117327 MIR122 0.44 7.08 0.36 8.82e-12 Platelet count; LUSC cis rs1832871 0.616 rs55675950 chr6:158773994 T/A cg07165851 chr6:158734300 TULP4 0.48 7.32 0.37 1.87e-12 Height; LUSC cis rs4478858 0.746 rs10798831 chr1:31688385 A/C cg00250761 chr1:31883323 NA 0.36 9.37 0.46 1.15e-18 Alcohol dependence; LUSC cis rs8022179 0.580 rs8013228 chr14:103842650 A/G cg12935359 chr14:103987150 CKB -0.62 -8.42 -0.42 1.11e-15 Monocyte count; LUSC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.14e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs6598955 0.671 rs10493030 chr1:26561856 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.8 -0.43 7.56e-17 Obesity-related traits; LUSC cis rs12594515 0.967 rs11070466 chr15:45984955 C/T cg19682013 chr15:45996608 NA 0.39 5.95 0.31 6.77e-9 Waist circumference;Weight; LUSC trans rs11098499 0.955 rs1397608 chr4:120161744 A/G cg25214090 chr10:38739885 LOC399744 0.46 6.71 0.34 8.23e-11 Corneal astigmatism; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg08280861 chr8:58055591 NA 0.55 6.26 0.32 1.19e-9 Developmental language disorder (linguistic errors); LUSC cis rs11677416 1.000 rs3783514 chr2:113547425 A/G cg27083787 chr2:113543245 IL1A 0.47 7.39 0.37 1.17e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs1372520 0.684 rs1442144 chr4:90736113 T/C cg14346243 chr4:90757452 SNCA -0.39 -5.7 -0.3 2.58e-8 Neuroticism; LUSC trans rs11098499 0.863 rs1552095 chr4:120460306 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.39 0.37 1.21e-12 Corneal astigmatism; LUSC cis rs7927771 0.507 rs7111606 chr11:47787538 G/A cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg04369109 chr6:150039330 LATS1 -0.6 -8.81 -0.43 7.08e-17 Lung cancer; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg04234412 chr22:24373322 LOC391322 -0.87 -14.0 -0.61 2.27e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7819412 0.522 rs10088853 chr8:10987967 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -6.39 -0.33 5.58e-10 Triglycerides; LUSC cis rs354225 0.597 rs4347868 chr2:54830616 G/A cg01766943 chr2:54829624 SPTBN1 0.46 7.28 0.37 2.45e-12 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10743145 chr19:45927001 ERCC1 -0.43 -6.13 -0.32 2.51e-9 Electrocardiographic conduction measures; LUSC cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg15997130 chr1:24165203 NA 0.55 8.93 0.44 2.82e-17 Immature fraction of reticulocytes; LUSC cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg07636037 chr3:49044803 WDR6 0.6 6.35 0.33 6.98e-10 Menarche (age at onset); LUSC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg25456477 chr12:86230367 RASSF9 0.4 6.9 0.35 2.62e-11 Major depressive disorder; LUSC cis rs13006833 0.739 rs291468 chr2:191188119 A/G cg21644426 chr2:191273491 MFSD6 0.43 6.16 0.32 2.1e-9 Urinary metabolites; LUSC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg15445000 chr17:37608096 MED1 0.38 6.64 0.34 1.24e-10 Glomerular filtration rate (creatinine); LUSC trans rs629535 0.814 rs652483 chr8:70055083 G/A cg21567404 chr3:27674614 NA 0.98 15.62 0.65 1.15e-41 Dupuytren's disease; LUSC cis rs12579753 1.000 rs10862368 chr12:82244514 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs2625529 0.878 rs2929511 chr15:72231682 C/T cg16672083 chr15:72433130 SENP8 0.49 8.15 0.41 7.45e-15 Red blood cell count; LUSC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg13531842 chr10:38383804 ZNF37A -0.48 -7.42 -0.38 9.51e-13 Extrinsic epigenetic age acceleration; LUSC trans rs1997103 1.000 rs4947503 chr7:55409427 G/T cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC trans rs9929218 0.954 rs57688464 chr16:68826109 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.14 -0.52 1e-24 Colorectal cancer; LUSC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs4629180 0.586 rs1509497 chr2:102138184 C/T cg04415270 chr2:102091202 RFX8 -0.42 -7.23 -0.37 3.24e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs67311347 0.713 rs4974018 chr3:40307419 G/A cg13683864 chr3:40499215 RPL14 -0.91 -16.07 -0.66 1.81e-43 Renal cell carcinoma; LUSC cis rs1595825 0.891 rs1851779 chr2:198647108 C/T cg00982548 chr2:198649783 BOLL -0.58 -7.21 -0.37 3.87e-12 Ulcerative colitis; LUSC cis rs3750082 0.582 rs7800883 chr7:32971282 G/A cg08946731 chr7:32981826 RP9P 0.42 6.8 0.35 4.81e-11 Glomerular filtration rate (creatinine); LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg05343316 chr1:45956843 TESK2 0.72 9.81 0.47 4.02e-20 Platelet count; LUSC cis rs7100689 0.622 rs4933378 chr10:82147057 T/C cg00277334 chr10:82204260 NA -0.5 -7.28 -0.37 2.37e-12 Post bronchodilator FEV1; LUSC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg05340658 chr4:99064831 C4orf37 0.68 11.4 0.53 1.19e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 0.618 rs8023508 chr15:44176103 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.63 -6.73 -0.35 7.2e-11 Lung cancer in ever smokers; LUSC cis rs372883 0.648 rs2832297 chr21:30742996 A/C cg24692254 chr21:30365293 RNF160 0.72 11.42 0.53 1.02e-25 Pancreatic cancer; LUSC cis rs9467160 0.651 rs7755403 chr6:24453447 C/G cg20631270 chr6:24437470 GPLD1 0.41 6.34 0.33 7.43e-10 Liver enzyme levels; LUSC cis rs174479 0.743 rs174464 chr11:61657926 A/G cg01500311 chr11:61656094 FADS3 0.4 6.96 0.36 1.8e-11 Sphingolipid levels; LUSC cis rs7903847 0.620 rs17112676 chr10:99122288 G/A cg08345082 chr10:99160200 RRP12 -0.35 -6.9 -0.35 2.62e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs13385 0.769 rs3822739 chr5:139625743 A/G cg26211634 chr5:139558579 C5orf32 0.46 7.05 0.36 1.01e-11 Atrial fibrillation; LUSC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg04944784 chr2:26401820 FAM59B -0.68 -9.83 -0.47 3.44e-20 Gut microbiome composition (summer); LUSC cis rs6762 0.748 rs3059 chr11:840319 C/T cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.68 -0.34 1e-10 Mean platelet volume; LUSC cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg01256987 chr12:42539512 GXYLT1 -0.45 -8.73 -0.43 1.23e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6918586 0.616 rs1056314 chr6:26114653 G/A cg17691542 chr6:26056736 HIST1H1C -0.4 -6.03 -0.31 4.41e-9 Schizophrenia; LUSC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg08499158 chr17:42289980 UBTF -0.54 -8.78 -0.43 8.69e-17 Total body bone mineral density; LUSC cis rs3820068 0.562 rs10927841 chr1:16045261 T/C cg24675056 chr1:15929824 NA 0.43 6.87 0.35 3.12e-11 Systolic blood pressure; LUSC cis rs6696846 0.749 rs61822566 chr1:205078660 T/C cg21545522 chr1:205238299 TMCC2 0.43 8.15 0.41 7.46e-15 Red blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27255459 chr8:37962652 ASH2L 0.44 6.05 0.31 3.99e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg13902645 chr11:5959945 NA -0.54 -8.03 -0.4 1.73e-14 DNA methylation (variation); LUSC cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg15423357 chr2:25149977 NA 0.43 8.73 0.43 1.25e-16 Body mass index; LUSC cis rs12413816 0.517 rs4750400 chr10:13765923 A/G cg16485048 chr10:13749193 FRMD4A 0.37 6.11 0.32 2.77e-9 Red cell distribution width; LUSC cis rs61863818 0.709 rs10786343 chr10:99159465 C/A cg08345082 chr10:99160200 RRP12 -0.34 -6.7 -0.34 8.94e-11 Monocyte percentage of white cells; LUSC cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -9.88 -0.48 2.23e-20 Chronic sinus infection; LUSC cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg00898013 chr13:113819073 PROZ -0.56 -8.08 -0.4 1.21e-14 Platelet distribution width; LUSC cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.0 0.58 1.55e-31 Chronic sinus infection; LUSC cis rs600231 0.708 rs2957268 chr11:65245816 A/G cg17120908 chr11:65337727 SSSCA1 -0.53 -9.22 -0.45 3.31e-18 Bone mineral density; LUSC cis rs113835537 0.529 rs11821155 chr11:66246337 C/T cg24851651 chr11:66362959 CCS -0.53 -7.87 -0.4 5.14e-14 Airway imaging phenotypes; LUSC cis rs8060686 0.623 rs74024145 chr16:68153382 G/C cg26727032 chr16:67993705 SLC12A4 -0.39 -6.01 -0.31 4.8e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10927875 0.632 rs4661666 chr1:16162471 C/A cg22431228 chr1:16359049 CLCNKA 0.34 6.42 0.33 4.7e-10 Dilated cardiomyopathy; LUSC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg13114125 chr14:105738426 BRF1 0.88 14.98 0.63 3.49e-39 Mean platelet volume;Platelet distribution width; LUSC cis rs7772486 0.875 rs9403765 chr6:146368041 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -8.86 -0.44 4.99e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs9902453 1.000 rs7212497 chr17:28335949 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.56 -8.42 -0.42 1.12e-15 Coffee consumption (cups per day); LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.63 9.73 0.47 7.25e-20 Lymphocyte counts; LUSC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg03233332 chr7:66118400 NA 0.42 6.09 0.32 3.02e-9 Aortic root size; LUSC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg27432699 chr2:27873401 GPN1 -0.47 -6.98 -0.36 1.55e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs11105298 0.891 rs3741899 chr12:89933931 G/A cg00757033 chr12:89920650 WDR51B 0.61 10.76 0.51 2.3e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg00864171 chr11:67383662 NA 0.34 5.96 0.31 6.34e-9 Mean corpuscular volume; LUSC cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg02466173 chr16:30829666 NA -0.58 -10.9 -0.51 7.11e-24 Multiple myeloma; LUSC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg24399712 chr22:39784796 NA -0.61 -10.28 -0.49 9.79e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs453301 0.686 rs7814328 chr8:8876229 T/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.68 -0.39 1.75e-13 Joint mobility (Beighton score); LUSC cis rs6681460 0.528 rs4655498 chr1:67039245 T/G cg02459107 chr1:67143332 SGIP1 0.32 5.71 0.3 2.53e-8 Presence of antiphospholipid antibodies; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07286436 chr15:43425883 TMEM62 -0.42 -6.26 -0.32 1.21e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11674863 chr7:107531486 DLD -0.4 -5.97 -0.31 6.13e-9 Electrocardiographic conduction measures; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24922631 chr19:19303269 RFXANK;LOC729991;LOC729991-MEF2B 0.43 6.02 0.31 4.68e-9 Triglycerides; LUSC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg05805236 chr11:65401703 PCNXL3 0.36 5.75 0.3 1.96e-8 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs140884840 1 rs140884840 chr10:25200805 AAAAC/A cg16316141 chr10:25305874 ENKUR;THNSL1 0.39 5.69 0.3 2.82e-8 Platelet count;Plateletcrit; LUSC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs440932 1.000 rs365309 chr8:9026940 C/T cg15556689 chr8:8085844 FLJ10661 -0.43 -6.16 -0.32 2.08e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg23788917 chr6:8435910 SLC35B3 0.5 7.35 0.37 1.5e-12 Motion sickness; LUSC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg21433313 chr16:3507492 NAT15 -0.61 -9.64 -0.47 1.42e-19 Tuberculosis; LUSC trans rs3858145 0.588 rs731063 chr10:70043190 A/G cg04882175 chr6:131122610 NA 0.62 8.4 0.42 1.25e-15 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23896311 chr4:122791762 BBS7 -0.46 -6.75 -0.35 6.41e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg12412775 chr1:25698385 RHCE -0.31 -6.32 -0.33 8.46e-10 Erythrocyte sedimentation rate; LUSC cis rs478304 0.651 rs7110576 chr11:65512057 T/G cg10604040 chr11:65559109 OVOL1 0.32 5.85 0.3 1.18e-8 Acne (severe); LUSC cis rs11608355 0.545 rs61941585 chr12:109905222 C/T cg05360138 chr12:110035743 NA 0.87 10.34 0.49 6.22e-22 Neuroticism; LUSC cis rs13253111 0.624 rs1979329 chr8:28096772 C/G cg26534493 chr8:28060551 NA 0.38 6.91 0.35 2.47e-11 Childhood body mass index; LUSC cis rs2637266 0.627 rs2013238 chr10:78476272 A/C cg18941641 chr10:78392320 NA 0.33 6.02 0.31 4.51e-9 Pulmonary function; LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.54 7.48 0.38 6.5e-13 Gut microbiome composition (summer); LUSC cis rs611744 0.816 rs626211 chr8:109189448 A/C cg18478394 chr8:109455254 TTC35 0.4 5.95 0.31 6.61e-9 Dupuytren's disease; LUSC cis rs9399135 0.967 rs1590975 chr6:135352088 C/T cg24558204 chr6:135376177 HBS1L 0.57 8.99 0.44 1.85e-17 Red blood cell count; LUSC cis rs7296418 0.580 rs78455769 chr12:123856443 G/A cg05973401 chr12:123451056 ABCB9 0.55 7.89 0.4 4.32e-14 Platelet count; LUSC cis rs17102423 0.755 rs7161394 chr14:65563309 G/T cg11161011 chr14:65562177 MAX -0.8 -12.14 -0.55 2.48e-28 Obesity-related traits; LUSC cis rs3126085 0.799 rs11589532 chr1:152176539 G/A cg26876637 chr1:152193138 HRNR -0.44 -6.12 -0.32 2.68e-9 Atopic dermatitis; LUSC cis rs722599 0.748 rs7145173 chr14:75351647 G/A cg08847533 chr14:75593920 NEK9 -0.48 -6.88 -0.35 3e-11 IgG glycosylation; LUSC cis rs2898290 0.622 rs7829381 chr8:11344573 A/G cg21775007 chr8:11205619 TDH -0.5 -7.54 -0.38 4.51e-13 Systolic blood pressure; LUSC cis rs6460942 0.591 rs6945587 chr7:12356992 G/A cg06484146 chr7:12443880 VWDE -0.57 -5.96 -0.31 6.56e-9 Coronary artery disease; LUSC cis rs9467773 0.869 rs1796520 chr6:26410800 C/T cg05738196 chr6:26577821 NA -0.65 -10.32 -0.49 7.71e-22 Intelligence (multi-trait analysis); LUSC cis rs10911232 0.507 rs4369195 chr1:182996291 G/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.82e-24 Hypertriglyceridemia; LUSC cis rs6733011 0.578 rs4851171 chr2:99510817 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -5.91 -0.31 8.61e-9 Bipolar disorder; LUSC cis rs501916 0.833 rs11855134 chr15:48047676 A/G cg16110827 chr15:48056943 SEMA6D -0.47 -7.16 -0.36 5.04e-12 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs13385 0.769 rs67836595 chr5:139603615 G/A cg26211634 chr5:139558579 C5orf32 0.45 6.56 0.34 2.05e-10 Atrial fibrillation; LUSC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg20503657 chr10:835505 NA 0.99 13.94 0.61 3.95e-35 Eosinophil percentage of granulocytes; LUSC cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg11584989 chr19:19387371 SF4 -0.59 -7.12 -0.36 6.62e-12 Bipolar disorder; LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6076960 0.652 rs3843045 chr20:6264593 C/T cg21095983 chr6:86352623 SYNCRIP -0.5 -8.13 -0.41 8.29e-15 Smooth-surface caries; LUSC cis rs10876993 0.890 rs1678539 chr12:58060359 A/G cg15848620 chr12:58087721 OS9 -0.53 -7.69 -0.39 1.68e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.32 -0.33 8.56e-10 Total body bone mineral density; LUSC cis rs7312933 0.558 rs1796381 chr12:42842475 C/T cg01256987 chr12:42539512 GXYLT1 -0.34 -6.21 -0.32 1.6e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4423214 1.000 rs4944958 chr11:71168073 A/G cg05163923 chr11:71159392 DHCR7 0.74 11.04 0.52 2.34e-24 Vitamin D levels; LUSC cis rs9400467 0.528 rs6913769 chr6:111792897 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.92 -0.35 2.29e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.9 -12.47 -0.56 1.48e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6674176 0.932 rs7412307 chr1:44433864 C/G cg13246856 chr1:44399776 ARTN -0.35 -7.08 -0.36 8.77e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg23262073 chr20:60523788 NA -0.38 -6.09 -0.32 3.13e-9 Body mass index; LUSC trans rs7647973 0.667 rs4241405 chr3:49642027 C/T cg21659725 chr3:3221576 CRBN -0.71 -7.8 -0.39 7.78e-14 Menarche (age at onset); LUSC cis rs1160297 0.544 rs10173886 chr2:53094788 T/C cg07782112 chr2:53107842 NA 0.39 6.45 0.33 3.82e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs61931739 0.529 rs1525900 chr12:33976652 T/G cg06521331 chr12:34319734 NA -0.41 -6.94 -0.36 2.04e-11 Morning vs. evening chronotype; LUSC cis rs9837602 0.872 rs4928234 chr3:99704861 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -6.17 -0.32 1.96e-9 Breast cancer; LUSC trans rs2204008 0.837 rs1842599 chr12:37986081 G/A cg06521331 chr12:34319734 NA 0.41 6.49 0.33 3.19e-10 Bladder cancer; LUSC cis rs28595532 0.748 rs72670249 chr4:119336823 G/T cg02775129 chr4:119771670 NA -0.76 -6.32 -0.33 8.59e-10 Cannabis dependence symptom count; LUSC trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg07701084 chr6:150067640 NUP43 0.53 7.89 0.4 4.41e-14 Lung cancer; LUSC cis rs7267979 1.000 rs4815418 chr20:25382211 T/G cg08601574 chr20:25228251 PYGB -0.43 -6.57 -0.34 1.93e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9300255 0.602 rs1716167 chr12:123651162 C/T cg05973401 chr12:123451056 ABCB9 -0.51 -6.37 -0.33 6.13e-10 Neutrophil percentage of white cells; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg25511237 chr20:57978889 NA 0.41 6.34 0.33 7.62e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs8114671 0.967 rs6088753 chr20:33768252 C/T cg24642439 chr20:33292090 TP53INP2 0.41 5.93 0.31 7.42e-9 Height; LUSC cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg07606381 chr6:8435919 SLC35B3 0.73 12.55 0.57 7.07e-30 Motion sickness; LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg00814883 chr7:100076585 TSC22D4 -0.66 -8.53 -0.42 5.25e-16 Platelet count; LUSC trans rs459571 1.000 rs2810489 chr9:136922700 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -13.06 -0.58 9.2e-32 Platelet distribution width; LUSC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.39 6.43 0.33 4.42e-10 Electroencephalogram traits; LUSC cis rs4363385 0.747 rs6670614 chr1:152964338 A/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.97 -0.4 2.61e-14 Inflammatory skin disease; LUSC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg03605463 chr16:89740564 NA 0.38 5.75 0.3 2.05e-8 Vitiligo; LUSC cis rs4423214 0.840 rs1792224 chr11:71176141 C/T cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC cis rs7572644 0.699 rs12466717 chr2:28096792 A/G cg27432699 chr2:27873401 GPN1 -0.51 -6.89 -0.35 2.86e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs17095355 0.605 rs7916801 chr10:111632445 A/G cg00817464 chr10:111662876 XPNPEP1 0.55 6.49 0.33 3.04e-10 Biliary atresia; LUSC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg17911788 chr17:44343683 NA 0.3 5.82 0.3 1.39e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg11843238 chr5:131593191 PDLIM4 0.39 6.54 0.34 2.28e-10 Breast cancer; LUSC cis rs1577917 0.958 rs11756510 chr6:86699794 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.73 -0.43 1.22e-16 Response to antipsychotic treatment; LUSC cis rs7727544 0.716 rs11949055 chr5:131576737 T/C cg12564285 chr5:131593104 PDLIM4 0.33 6.01 0.31 4.76e-9 Blood metabolite levels; LUSC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg03060546 chr3:49711283 APEH 0.71 11.94 0.55 1.29e-27 Resting heart rate; LUSC cis rs7584330 0.657 rs10211024 chr2:238353776 A/T cg14458575 chr2:238380390 NA 0.67 11.98 0.55 9.09e-28 Prostate cancer; LUSC cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg17366294 chr4:99064904 C4orf37 0.61 10.91 0.51 6.72e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1595825 0.891 rs76308665 chr2:198518062 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.32e-10 Ulcerative colitis; LUSC cis rs1152591 0.543 rs1152594 chr14:64675044 C/T cg21174375 chr14:64681225 SYNE2 -0.34 -6.22 -0.32 1.45e-9 Atrial fibrillation; LUSC cis rs912057 0.526 rs1294400 chr6:6733421 A/G cg06612196 chr6:6737390 NA -0.63 -13.05 -0.58 9.81e-32 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs4947962 0.585 rs7785013 chr7:55152667 A/G cg23757825 chr7:55092271 EGFR 0.46 5.78 0.3 1.74e-8 Subjective response to lithium treatment; LUSC cis rs9395066 0.545 rs17424547 chr6:44988970 A/G cg25276700 chr6:44698697 NA 0.29 5.97 0.31 6.21e-9 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18662566 chr2:128643056 AMMECR1L -0.38 -6.08 -0.32 3.3e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg07606381 chr6:8435919 SLC35B3 -0.73 -12.08 -0.55 4.1e-28 Motion sickness; LUSC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg02569458 chr12:86230093 RASSF9 0.59 10.0 0.48 8.85e-21 Major depressive disorder; LUSC cis rs259282 0.652 rs2161458 chr19:33129038 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.79 12.8 0.57 8.2e-31 Schizophrenia; LUSC cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg22508957 chr16:3507546 NAT15 0.42 6.7 0.34 9.01e-11 Body mass index (adult); LUSC trans rs225245 0.817 rs225302 chr17:33922396 C/T cg19694781 chr19:47549865 TMEM160 -0.41 -6.55 -0.34 2.17e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs11039100 0.607 rs11038940 chr11:5777739 T/C cg05234568 chr11:5960015 NA -0.42 -5.68 -0.3 2.97e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6977660 0.714 rs10249477 chr7:19805388 T/A cg05791153 chr7:19748676 TWISTNB 0.69 7.43 0.38 9.12e-13 Thyroid stimulating hormone; LUSC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg06484146 chr7:12443880 VWDE -0.68 -7.18 -0.37 4.69e-12 Coronary artery disease; LUSC trans rs11098499 0.780 rs7680914 chr4:120563053 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.3 0.33 9.6e-10 Corneal astigmatism; LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02475777 chr4:1388615 CRIPAK 0.58 8.85 0.44 5.19e-17 Longevity; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04974121 chr4:20701990 PACRGL -0.39 -6.42 -0.33 4.55e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7215564 0.908 rs2316061 chr17:78663660 A/G cg23238734 chr17:78661607 RPTOR 0.47 6.11 0.32 2.82e-9 Myopia (pathological); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24321774 chr2:27193835 MAPRE3 -0.45 -6.35 -0.33 7.01e-10 Bipolar disorder and schizophrenia; LUSC cis rs929354 1.000 rs1182389 chr7:157038803 C/T cg17757837 chr7:157058334 UBE3C 0.9 14.71 0.63 4.2e-38 Body mass index; LUSC cis rs11864453 0.826 rs6499560 chr16:72147666 G/T cg23815491 chr16:72088622 HP -0.35 -6.04 -0.31 4.19e-9 Fibrinogen levels; LUSC cis rs79976124 0.800 rs12194767 chr6:66639599 A/G cg07460842 chr6:66804631 NA 0.71 8.75 0.43 1.07e-16 Type 2 diabetes; LUSC cis rs9341808 0.500 rs2223873 chr6:81048288 A/G cg08355045 chr6:80787529 NA 0.48 8.3 0.41 2.69e-15 Sitting height ratio; LUSC cis rs754466 0.651 rs11818687 chr10:79637709 C/T cg17075019 chr10:79541650 NA -0.76 -12.18 -0.55 1.73e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7599312 0.963 rs6735267 chr2:213403863 C/T cg16329650 chr2:213403929 ERBB4 0.65 9.03 0.44 1.42e-17 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4474465 0.790 rs6592785 chr11:78235095 C/T cg27205649 chr11:78285834 NARS2 0.52 6.09 0.32 3.17e-9 Alzheimer's disease (survival time); LUSC cis rs1670533 1.000 rs10084889 chr4:1053815 G/A cg02018176 chr4:1364513 KIAA1530 0.43 6.15 0.32 2.24e-9 Recombination rate (females); LUSC trans rs11098499 0.863 rs1010739 chr4:120463471 C/T cg25214090 chr10:38739885 LOC399744 0.51 7.51 0.38 5.54e-13 Corneal astigmatism; LUSC cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2354432 0.556 rs7516165 chr1:146866418 G/T cg25205988 chr1:146714368 CHD1L 0.86 7.6 0.38 2.98e-13 Mitochondrial DNA levels; LUSC cis rs9399135 1.000 rs4895435 chr6:135293463 C/A cg22676075 chr6:135203613 NA 0.48 7.42 0.38 9.61e-13 Red blood cell count; LUSC cis rs2324229 0.828 rs1180194 chr6:83962421 C/T cg08257003 chr6:84140564 ME1 0.32 7.52 0.38 5.02e-13 Platelet-derived growth factor BB levels; LUSC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg02079420 chr8:82753780 SNX16 0.41 6.97 0.36 1.69e-11 Diastolic blood pressure; LUSC cis rs11190604 0.767 rs4559620 chr10:102199935 C/T cg07080220 chr10:102295463 HIF1AN 0.62 8.13 0.41 8.51e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2073300 0.609 rs74273791 chr20:23418067 A/T cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg03396347 chr1:1875803 NA 0.48 10.32 0.49 7.56e-22 Body mass index; LUSC cis rs13256369 0.851 rs13266562 chr8:8564065 T/C cg17143192 chr8:8559678 CLDN23 0.63 9.07 0.44 1.02e-17 Obesity-related traits; LUSC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg06238570 chr21:40685208 BRWD1 0.53 7.87 0.4 5.12e-14 Cognitive function; LUSC cis rs2370759 1.000 rs78959390 chr10:32616346 C/T cg01819863 chr10:32635814 EPC1 1.06 13.11 0.58 5.81e-32 Sexual dysfunction (female); LUSC cis rs12989701 0.877 rs7557280 chr2:127873161 T/A cg08168897 chr2:127865431 BIN1 0.73 9.32 0.45 1.65e-18 Alzheimer's disease (late onset); LUSC cis rs981844 0.807 rs56053818 chr4:154638126 T/A cg14289246 chr4:154710475 SFRP2 0.43 5.82 0.3 1.4e-8 Response to statins (LDL cholesterol change); LUSC cis rs12286929 0.679 rs11601041 chr11:115083348 A/G cg04055981 chr11:115044050 NA 0.36 6.33 0.33 7.78e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7917772 0.545 rs3934960 chr10:104355275 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.81 -0.51 1.47e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6138458 1.000 rs6114980 chr20:24974288 A/G cg06937882 chr20:24974362 C20orf3 -0.44 -7.67 -0.39 1.89e-13 Blood protein levels; LUSC cis rs7829975 0.508 rs4841006 chr8:8501474 T/C cg15556689 chr8:8085844 FLJ10661 -0.55 -8.62 -0.43 2.63e-16 Mood instability; LUSC cis rs1577917 0.958 rs10455448 chr6:86533611 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.52 -8.31 -0.41 2.52e-15 Prudent dietary pattern; LUSC cis rs3829109 0.534 rs563 chr9:139296485 C/T cg14169450 chr9:139327907 INPP5E -0.4 -6.07 -0.32 3.49e-9 Peak insulin response;Acute insulin response; LUSC cis rs4595586 0.545 rs1349257 chr12:39397139 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.08 0.32 3.29e-9 Morning vs. evening chronotype; LUSC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg20608306 chr11:116969690 SIK3 -0.38 -6.35 -0.33 6.84e-10 Blood protein levels; LUSC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg00339695 chr16:24857497 SLC5A11 -0.61 -9.23 -0.45 3.25e-18 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.06e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg03146154 chr1:46216737 IPP 0.54 8.22 0.41 4.47e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC cis rs7020830 0.898 rs506981 chr9:37351348 A/T cg14294708 chr9:37120828 ZCCHC7 -0.99 -21.34 -0.76 2.39e-64 Schizophrenia; LUSC cis rs10782582 0.593 rs12131344 chr1:76136437 C/T cg10523679 chr1:76189770 ACADM -0.51 -7.04 -0.36 1.13e-11 Daytime sleep phenotypes; LUSC cis rs6541297 0.699 rs4846915 chr1:230296470 C/A cg05784532 chr1:230284198 GALNT2 0.58 6.68 0.34 9.94e-11 Coronary artery disease; LUSC cis rs587080 0.624 rs512715 chr11:65191208 C/G cg21890820 chr11:65308645 LTBP3 -0.48 -6.7 -0.34 8.68e-11 Plateletcrit; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14633757 chr17:80231324 CSNK1D -0.53 -6.46 -0.33 3.69e-10 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg23758822 chr17:41437982 NA 1.04 20.17 0.74 1.03e-59 Menopause (age at onset); LUSC cis rs11214589 0.774 rs10891544 chr11:113256152 A/C cg14159747 chr11:113255604 NA -0.29 -7.65 -0.39 2.13e-13 Neuroticism; LUSC cis rs7586879 0.789 rs13382979 chr2:25131736 G/A cg01884057 chr2:25150051 NA 0.41 8.4 0.42 1.26e-15 Body mass index; LUSC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg11366901 chr6:160182831 ACAT2 0.97 13.07 0.58 8.27e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs4803468 1.000 rs11880539 chr19:41918949 A/C cg09537434 chr19:41945824 ATP5SL 0.86 14.62 0.62 9.31e-38 Height; LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg08968635 chr6:28129556 ZNF389 0.45 5.67 0.3 3.06e-8 Parkinson's disease; LUSC cis rs7937682 0.924 rs10891283 chr11:111527672 A/G cg22437258 chr11:111473054 SIK2 0.5 6.89 0.35 2.78e-11 Primary sclerosing cholangitis; LUSC cis rs6484504 0.576 rs2616792 chr11:31324298 T/G cg06552810 chr11:31128660 NA 0.4 6.89 0.35 2.71e-11 Red blood cell count; LUSC cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg26061582 chr7:22766209 IL6 0.45 6.54 0.34 2.26e-10 Lung cancer; LUSC cis rs2742234 0.541 rs10899778 chr10:43718509 G/C cg15436174 chr10:43711423 RASGEF1A 0.44 7.06 0.36 9.75e-12 Hirschsprung disease; LUSC cis rs4595586 0.546 rs2056159 chr12:39270417 C/G cg13010199 chr12:38710504 ALG10B 0.62 9.03 0.44 1.39e-17 Morning vs. evening chronotype; LUSC cis rs1670533 1.000 rs11725984 chr4:1087338 C/T cg02018176 chr4:1364513 KIAA1530 0.48 6.59 0.34 1.74e-10 Recombination rate (females); LUSC cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg20503657 chr10:835505 NA -0.49 -6.86 -0.35 3.31e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs908922 0.676 rs545418 chr1:152497338 C/T cg20991723 chr1:152506922 NA 0.52 9.8 0.47 4.38e-20 Hair morphology; LUSC trans rs11992162 0.573 rs61468577 chr8:11784925 A/C cg06636001 chr8:8085503 FLJ10661 -0.43 -6.02 -0.31 4.47e-9 Monocyte count; LUSC cis rs807669 0.770 rs807458 chr22:19220648 G/A cg26795923 chr22:19165960 SLC25A1 0.82 6.45 0.33 4.01e-10 Metabolite levels; LUSC cis rs68170813 0.559 rs74584447 chr7:106944755 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.64 -0.3 3.56e-8 Coronary artery disease; LUSC cis rs950881 0.799 rs72823669 chr2:102982033 G/T cg20060108 chr2:102954350 IL1RL1 0.49 6.2 0.32 1.63e-9 Allergy; LUSC cis rs7113850 0.551 rs4365050 chr11:24245730 G/A ch.11.24196551F chr11:24239977 NA 1.01 9.09 0.45 9.05e-18 Bone fracture in osteoporosis; LUSC cis rs9790314 0.669 rs7630768 chr3:160864879 T/A cg03342759 chr3:160939853 NMD3 -0.44 -7.37 -0.37 1.34e-12 Morning vs. evening chronotype; LUSC cis rs7172677 0.768 rs72730583 chr15:75351630 T/C cg14664628 chr15:75095509 CSK 0.49 6.43 0.33 4.34e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg18402987 chr7:1209562 NA 0.45 5.86 0.31 1.1e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2455601 0.574 rs2568094 chr11:8992218 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.32 -0.33 8.16e-10 Schizophrenia; LUSC cis rs66887589 0.967 rs59516282 chr4:120502016 G/A cg24375607 chr4:120327624 NA -0.46 -7.03 -0.36 1.17e-11 Diastolic blood pressure; LUSC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg02574844 chr11:5959923 NA 0.5 7.56 0.38 4.04e-13 DNA methylation (variation); LUSC cis rs9467711 0.606 rs9393718 chr6:26407482 G/A cg12826209 chr6:26865740 GUSBL1 0.64 5.65 0.3 3.37e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg02353165 chr6:42928485 GNMT 0.65 11.28 0.53 3.11e-25 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs899997 0.731 rs58717592 chr15:79030417 T/C cg04896959 chr15:78267971 NA -0.53 -10.06 -0.48 5.87e-21 Coronary artery disease or large artery stroke; LUSC cis rs6546537 1.000 rs6727435 chr2:69864236 C/A cg10773587 chr2:69614142 GFPT1 -0.53 -7.85 -0.39 5.77e-14 Serum thyroid-stimulating hormone levels; LUSC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg11344533 chr11:111475393 SIK2 -0.44 -5.74 -0.3 2.14e-8 Primary sclerosing cholangitis; LUSC cis rs7107174 0.892 rs2511167 chr11:77964698 C/T cg02023728 chr11:77925099 USP35 0.49 7.15 0.36 5.56e-12 Testicular germ cell tumor; LUSC cis rs34779708 0.966 rs7913615 chr10:35422957 T/G cg04310649 chr10:35416472 CREM -0.4 -6.24 -0.32 1.3e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg07741184 chr6:167504864 NA 0.35 6.41 0.33 4.97e-10 Crohn's disease; LUSC cis rs6964587 1.000 rs12531366 chr7:91683849 C/G cg01689657 chr7:91764605 CYP51A1 0.33 6.03 0.31 4.39e-9 Breast cancer; LUSC cis rs1670533 0.818 rs643484 chr4:1085826 A/G cg02018176 chr4:1364513 KIAA1530 0.45 6.42 0.33 4.68e-10 Recombination rate (females); LUSC trans rs5760842 0.517 rs2076930 chr22:25495138 T/C cg16733866 chr21:42792609 MX1 0.5 7.0 0.36 1.39e-11 Recurrent major depressive disorder; LUSC cis rs4664308 1.000 rs10929966 chr2:160908341 C/T cg03641300 chr2:160917029 PLA2R1 -0.67 -11.38 -0.53 1.42e-25 Idiopathic membranous nephropathy; LUSC trans rs1728785 1.000 rs1170434 chr16:68606590 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.5 0.42 6.47e-16 Ulcerative colitis; LUSC cis rs7568458 0.709 rs11895399 chr2:85753806 C/A cg17127132 chr2:85788382 GGCX 0.41 5.93 0.31 7.66e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9467773 1.000 rs9393728 chr6:26509330 C/G cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.95e-18 Intelligence (multi-trait analysis); LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18099408 chr3:52552593 STAB1 -0.48 -8.56 -0.42 4.15e-16 Bipolar disorder; LUSC cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg24634471 chr8:143751801 JRK -0.51 -7.12 -0.36 6.67e-12 Schizophrenia; LUSC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.57 0.5 1.02e-22 Colonoscopy-negative controls vs population controls; LUSC trans rs7824557 0.736 rs35392635 chr8:11164349 G/C cg08975724 chr8:8085496 FLJ10661 0.45 6.66 0.34 1.1e-10 Retinal vascular caliber; LUSC cis rs9902453 0.904 rs6505148 chr17:28289818 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.62 0.5 6.6e-23 Coffee consumption (cups per day); LUSC cis rs6882046 0.513 rs679232 chr5:88054763 A/C cg22951263 chr5:87985283 NA 0.45 7.38 0.37 1.29e-12 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs10779751 0.734 rs2486920 chr1:11125050 T/C cg08854313 chr1:11322531 MTOR 0.79 11.58 0.54 2.78e-26 Body mass index; LUSC cis rs7903847 0.620 rs17112674 chr10:99122178 C/T cg20016023 chr10:99160130 RRP12 0.31 7.48 0.38 6.46e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs4803468 1.000 rs4803469 chr19:41922775 A/C cg09537434 chr19:41945824 ATP5SL -0.91 -15.86 -0.66 1.23e-42 Height; LUSC cis rs7937682 0.921 rs10891280 chr11:111433609 A/T cg19812747 chr11:111475976 SIK2 0.52 7.17 0.37 4.78e-12 Primary sclerosing cholangitis; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg21280719 chr6:42927975 GNMT -0.32 -7.96 -0.4 2.77e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7586879 0.828 rs11675013 chr2:25107208 G/A cg01884057 chr2:25150051 NA 0.41 8.61 0.43 3.02e-16 Body mass index; LUSC cis rs954108 0.809 rs715704 chr13:29369317 C/T cg11788234 chr13:29393811 NA -0.39 -6.75 -0.35 6.41e-11 Obesity-related traits; LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.39 0.33 5.42e-10 Renal function-related traits (BUN); LUSC cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.37 -5.99 -0.31 5.43e-9 IgG glycosylation; LUSC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21702128 chr5:142784721 NR3C1 0.42 6.11 0.32 2.84e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs950027 0.787 rs1153845 chr15:45724729 C/T cg14582100 chr15:45693742 SPATA5L1 -0.34 -6.35 -0.33 7.05e-10 Response to fenofibrate (adiponectin levels); LUSC cis rs34172651 0.917 rs1465422 chr16:24772486 C/T cg06028605 chr16:24865363 SLC5A11 0.47 8.52 0.42 5.36e-16 Intelligence (multi-trait analysis); LUSC cis rs2124969 0.548 rs72979963 chr2:161014483 A/G cg03641300 chr2:160917029 PLA2R1 -0.47 -5.7 -0.3 2.7e-8 Waist circumference adjusted for body mass index; LUSC cis rs10857712 0.754 rs7921041 chr10:135229239 G/C cg01444801 chr10:135216882 MTG1 -0.5 -6.55 -0.34 2.15e-10 Systemic lupus erythematosus; LUSC trans rs9329221 0.506 rs17689674 chr8:9981854 C/A cg21775007 chr8:11205619 TDH 0.46 6.65 0.34 1.19e-10 Neuroticism; LUSC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg09365446 chr1:150670422 GOLPH3L 0.46 6.74 0.35 7.09e-11 Melanoma; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21872393 chr18:3247654 MYL12A 0.49 7.04 0.36 1.12e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9868809 0.505 rs28793701 chr3:48762683 C/G cg00383909 chr3:49044727 WDR6 1.1 9.65 0.47 1.36e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2274273 0.901 rs8011288 chr14:55735112 C/T cg04306507 chr14:55594613 LGALS3 0.57 13.76 0.6 1.98e-34 Protein biomarker; LUSC cis rs6964587 0.869 rs2023784 chr7:91524677 A/G cg17063962 chr7:91808500 NA -0.53 -8.18 -0.41 6.04e-15 Breast cancer; LUSC trans rs539514 0.690 rs607095 chr13:76316165 A/T cg05302441 chr11:125157402 PKNOX2 0.26 6.0 0.31 5.12e-9 Type 1 diabetes; LUSC cis rs7582720 1.000 rs114123510 chr2:203831212 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10832963 0.686 rs11024743 chr11:18653712 A/G cg20219074 chr11:18656078 SPTY2D1 0.72 10.81 0.51 1.49e-23 Breast cancer; LUSC cis rs6951245 0.882 rs10252404 chr7:1209607 C/A cg08132940 chr7:1081526 C7orf50 -0.51 -5.99 -0.31 5.3300000000000004e-09 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg27432699 chr2:27873401 GPN1 -0.58 -8.69 -0.43 1.62e-16 Total body bone mineral density; LUSC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg22920501 chr2:26401640 FAM59B -0.75 -10.64 -0.5 5.79e-23 Gut microbiome composition (summer); LUSC cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC trans rs1005277 0.540 rs2224248 chr10:38451886 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.59 -0.46 2.1e-19 Extrinsic epigenetic age acceleration; LUSC cis rs977987 0.902 rs4888430 chr16:75494424 T/C cg04384234 chr16:75411784 CFDP1 -0.48 -8.01 -0.4 1.93e-14 Dupuytren's disease; LUSC trans rs7395662 0.571 rs4881998 chr11:48525186 C/T cg15704280 chr7:45808275 SEPT13 -0.44 -6.1 -0.32 3e-9 HDL cholesterol; LUSC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.85e-15 Homoarginine levels; LUSC cis rs1670533 1.000 rs10003009 chr4:1050849 G/A cg27284194 chr4:1044797 NA 0.57 8.39 0.42 1.35e-15 Recombination rate (females); LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg21548813 chr6:291882 DUSP22 0.47 7.2 0.37 4.07e-12 Menopause (age at onset); LUSC cis rs4803468 1.000 rs4803465 chr19:41918158 A/G cg09537434 chr19:41945824 ATP5SL 0.91 16.1 0.66 1.43e-43 Height; LUSC cis rs10927875 0.864 rs1976402 chr1:16143779 G/A cg21385522 chr1:16154831 NA -0.95 -16.21 -0.66 5.44e-44 Dilated cardiomyopathy; LUSC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg16743903 chr16:89593216 SPG7 -0.38 -5.85 -0.3 1.19e-8 Multiple myeloma (IgH translocation); LUSC cis rs7166081 0.738 rs2286664 chr15:67701495 A/G cg05925327 chr15:68127851 NA -0.36 -5.78 -0.3 1.72e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg18827107 chr12:86230957 RASSF9 -0.49 -7.11 -0.36 7.04e-12 Major depressive disorder; LUSC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg05234568 chr11:5960015 NA -0.58 -9.21 -0.45 3.72e-18 DNA methylation (variation); LUSC cis rs7527798 1.000 rs36001492 chr1:207841745 A/T cg09232269 chr1:207846808 CR1L -0.32 -5.8 -0.3 1.56e-8 Erythrocyte sedimentation rate; LUSC cis rs7312933 0.584 rs6582395 chr12:42700141 T/C cg01256987 chr12:42539512 GXYLT1 -0.4 -7.31 -0.37 2.03e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg21856205 chr7:94953877 PON1 -0.36 -5.8 -0.3 1.56e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg06640241 chr16:89574553 SPG7 0.69 10.83 0.51 1.23e-23 Multiple myeloma (IgH translocation); LUSC cis rs9399401 0.845 rs263188 chr6:142860028 C/T cg03128060 chr6:142623767 GPR126 0.32 6.05 0.31 3.86e-9 Chronic obstructive pulmonary disease; LUSC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg21028142 chr17:79581711 NPLOC4 -0.33 -7.56 -0.38 4.01e-13 Eye color traits; LUSC cis rs4595586 0.545 rs7310463 chr12:39368927 T/C cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.87 0.35 3.22e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.09 -0.36 8e-12 Major depressive disorder; LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.37 5.69 0.3 2.73e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.2 0.45 3.91e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7223966 0.883 rs2727317 chr17:61961302 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.16 0.36 5.3e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg11645453 chr3:52864694 ITIH4 0.4 8.73 0.43 1.23e-16 Bipolar disorder; LUSC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg06850241 chr22:41845214 NA -0.3 -5.75 -0.3 2e-8 Vitiligo; LUSC cis rs6977660 0.619 rs10231972 chr7:19789354 C/G cg05791153 chr7:19748676 TWISTNB 0.63 7.17 0.37 4.86e-12 Thyroid stimulating hormone; LUSC cis rs16976116 0.901 rs2899580 chr15:55491571 A/G cg11288833 chr15:55489084 RSL24D1 0.49 5.9 0.31 9.16e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4588572 0.643 rs10063319 chr5:77758425 T/C cg11547950 chr5:77652471 NA -0.56 -7.9 -0.4 4.04e-14 Triglycerides; LUSC cis rs12310956 0.510 rs4931759 chr12:33871969 T/C cg06521331 chr12:34319734 NA -0.36 -5.95 -0.31 6.73e-9 Morning vs. evening chronotype; LUSC cis rs17125944 0.686 rs77625717 chr14:53336544 T/C cg00686598 chr14:53173677 PSMC6 0.84 6.89 0.35 2.81e-11 Alzheimer's disease (late onset); LUSC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg23845507 chr1:91966731 CDC7 0.37 6.04 0.31 4e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs17253792 0.822 rs79807559 chr14:56108117 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.28e-10 Putamen volume; LUSC cis rs9467773 0.620 rs2451737 chr6:26619041 T/C cg11502198 chr6:26597334 ABT1 0.7 11.83 0.54 3.39e-27 Intelligence (multi-trait analysis); LUSC cis rs447735 0.507 rs11645271 chr16:89729125 G/T cg01097406 chr16:89675127 NA -0.29 -5.71 -0.3 2.51e-8 Hemoglobin concentration; LUSC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs1729407 0.695 rs1263176 chr11:116690123 T/C cg08985259 chr11:116699649 APOC3 -0.25 -5.71 -0.3 2.52e-8 Apolipoprotein A-IV levels; LUSC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs11048434 0.736 rs11048195 chr12:9105923 A/G cg23795048 chr12:9217529 LOC144571 0.34 5.94 0.31 7.26e-9 Sjögren's syndrome; LUSC trans rs6601327 0.585 rs1394 chr8:9511654 G/A cg15556689 chr8:8085844 FLJ10661 -0.47 -6.63 -0.34 1.36e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs11587400 0.679 rs6537834 chr1:115108870 T/C cg12756093 chr1:115239321 AMPD1 0.4 5.93 0.31 7.76e-9 Autism; LUSC cis rs10751667 0.666 rs7394427 chr11:970405 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.19e-10 Alzheimer's disease (late onset); LUSC cis rs4363385 0.818 rs10788853 chr1:153002231 C/T cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs13315871 1.000 rs4362735 chr3:58429893 C/G cg20936604 chr3:58311152 NA -0.66 -6.58 -0.34 1.79e-10 Cholesterol, total; LUSC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.65 0.34 1.2e-10 Lung cancer; LUSC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.68 -0.39 1.75e-13 Aortic root size; LUSC cis rs1801251 1.000 rs283468 chr2:233658309 C/T cg25237894 chr2:233734115 C2orf82 0.36 6.21 0.32 1.59e-9 Coronary artery disease; LUSC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg16586182 chr3:47516702 SCAP 0.52 8.26 0.41 3.35e-15 Colorectal cancer; LUSC cis rs208520 0.661 rs7740835 chr6:66865548 G/A cg07460842 chr6:66804631 NA -1.13 -17.71 -0.7 6.06e-50 Exhaled nitric oxide output; LUSC trans rs9929218 0.953 rs2902323 chr16:68736292 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.85 -12.74 -0.57 1.48e-30 Colorectal cancer; LUSC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg12751644 chr20:60527061 NA -0.36 -6.47 -0.33 3.45e-10 Body mass index; LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg05025164 chr4:1340916 KIAA1530 -0.5 -7.65 -0.39 2.21e-13 Obesity-related traits; LUSC trans rs61931739 0.749 rs7315233 chr12:34271975 G/T cg13010199 chr12:38710504 ALG10B 0.38 6.05 0.31 3.91e-9 Morning vs. evening chronotype; LUSC cis rs7267979 0.934 rs4815423 chr20:25387521 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.38 -0.73 1.37e-56 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg13175981 chr1:150552382 MCL1 0.53 7.56 0.38 4.01e-13 Tonsillectomy; LUSC cis rs10779751 0.770 rs12097293 chr1:11197467 A/G cg08854313 chr1:11322531 MTOR -0.83 -12.62 -0.57 3.88e-30 Body mass index; LUSC cis rs9549367 0.713 rs9549691 chr13:113861606 A/C cg18105134 chr13:113819100 PROZ -0.76 -11.03 -0.52 2.42e-24 Platelet distribution width; LUSC cis rs1059312 0.500 rs12303338 chr12:129276641 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.57 8.19 0.41 5.73e-15 Systemic lupus erythematosus; LUSC cis rs2282802 0.685 rs10077671 chr5:139689505 C/T cg26211634 chr5:139558579 C5orf32 0.42 8.11 0.41 9.79e-15 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.16 0.36 5.16e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.893 rs741437 chr2:15626327 A/G cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs892961 0.932 rs3987887 chr17:75414862 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.58 0.46 2.26e-19 Airflow obstruction; LUSC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.68 -0.39 1.81e-13 Height; LUSC trans rs17039065 0.920 rs1562973 chr4:109408138 G/T cg07444054 chr2:108107501 NA 0.43 6.25 0.32 1.23e-9 Gut microbiome composition (summer); LUSC cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg02574844 chr11:5959923 NA -0.47 -6.75 -0.35 6.74e-11 DNA methylation (variation); LUSC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg26380479 chr7:97908229 NA -0.26 -5.84 -0.3 1.24e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs1728785 0.901 rs11075688 chr16:68655924 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.58 -7.31 -0.37 1.98e-12 Ulcerative colitis; LUSC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg22903657 chr4:1355424 KIAA1530 -0.36 -5.96 -0.31 6.28e-9 Longevity; LUSC cis rs11155671 0.517 rs9397058 chr6:150207249 C/T cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.15e-11 Testicular germ cell tumor; LUSC cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg11244672 chr19:19639970 YJEFN3 -0.58 -6.97 -0.36 1.72e-11 Bipolar disorder; LUSC cis rs1559088 0.901 rs7249983 chr19:33598851 C/A cg03563238 chr19:33554763 RHPN2 -0.39 -6.36 -0.33 6.68e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4478858 0.735 rs12126725 chr1:31805853 G/T cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs7789940 1.000 rs11765693 chr7:75985373 A/G cg15798862 chr7:76129360 DTX2 -0.51 -8.54 -0.42 4.77e-16 Multiple sclerosis; LUSC cis rs2011503 0.941 rs17751061 chr19:19413092 C/T cg11584989 chr19:19387371 SF4 0.51 6.41 0.33 4.89e-10 Bipolar disorder; LUSC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg16680214 chr1:154839983 KCNN3 -0.53 -10.03 -0.48 6.96e-21 Prostate cancer; LUSC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg15212455 chr7:39170539 POU6F2 0.66 11.52 0.53 4.51e-26 IgG glycosylation; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg23758822 chr17:41437982 NA 1.04 20.11 0.74 1.65e-59 Menopause (age at onset); LUSC trans rs1005277 0.579 rs2008449 chr10:38414204 A/T cg17830980 chr10:43048298 ZNF37B 0.6 9.71 0.47 8.35e-20 Extrinsic epigenetic age acceleration; LUSC cis rs6504663 0.525 rs557 chr17:48563234 C/T cg22571038 chr17:48585470 MYCBPAP 0.46 5.85 0.3 1.18e-8 Visceral fat; LUSC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg20476274 chr7:133979776 SLC35B4 0.84 15.04 0.64 2.21e-39 Mean platelet volume; LUSC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg01503450 chr10:980765 NA -0.39 -5.79 -0.3 1.59e-8 Eosinophil percentage of granulocytes; LUSC trans rs2898290 0.622 rs978804 chr8:11343673 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -8.38 -0.42 1.52e-15 Systolic blood pressure; LUSC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg05234568 chr11:5960015 NA -0.57 -8.29 -0.41 2.82e-15 DNA methylation (variation); LUSC cis rs9300255 0.602 rs1569068 chr12:123632276 A/G cg05973401 chr12:123451056 ABCB9 -0.42 -5.65 -0.3 3.49e-8 Neutrophil percentage of white cells; LUSC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg19052272 chr2:3704530 ALLC 0.42 7.86 0.4 5.33e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1008375 1.000 rs9991307 chr4:17662408 A/G cg15017067 chr4:17643749 FAM184B 0.35 5.72 0.3 2.41e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs11637445 0.677 rs1564278 chr15:68107388 G/C cg08079166 chr15:68083412 MAP2K5 0.36 7.38 0.37 1.25e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg00129232 chr17:37814104 STARD3 -0.49 -7.28 -0.37 2.37e-12 Asthma; LUSC cis rs737337 0.623 rs4804154 chr19:11334179 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.55 6.84 0.35 3.75e-11 HDL cholesterol;HDL cholesterol levels; LUSC trans rs11696501 0.688 rs2072974 chr20:44313401 G/A cg03272292 chr12:48577362 C12orf68 0.5 6.01 0.31 4.88e-9 Brain structure; LUSC cis rs10435719 0.753 rs9694940 chr8:11789858 G/C cg21775007 chr8:11205619 TDH 0.46 6.57 0.34 1.93e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg11965913 chr1:205819406 PM20D1 -0.5 -7.12 -0.36 6.81e-12 Parkinson's disease; LUSC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg19592336 chr6:28129416 ZNF389 0.48 6.27 0.32 1.11e-9 Parkinson's disease; LUSC cis rs896543 0.702 rs12692188 chr2:237495929 A/G cg25295825 chr2:237489920 CXCR7 0.51 6.2 0.32 1.62e-9 Alcohol dependence (age at onset); LUSC cis rs2667011 0.818 rs2667000 chr2:160850354 A/T cg06573604 chr2:160760825 LY75 -0.5 -6.42 -0.33 4.78e-10 Bilirubin levels; LUSC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.76 0.3 1.9e-8 Menopause (age at onset); LUSC cis rs952623 0.649 rs6462886 chr7:39066567 A/T cg15212455 chr7:39170539 POU6F2 -0.35 -5.77 -0.3 1.8e-8 Intelligence (multi-trait analysis); LUSC cis rs4664308 0.618 rs62175487 chr2:160892521 C/T cg03641300 chr2:160917029 PLA2R1 -0.48 -7.9 -0.4 4.1e-14 Idiopathic membranous nephropathy; LUSC trans rs3808502 0.527 rs2736374 chr8:11113828 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.21 -0.32 1.6e-9 Neuroticism; LUSC trans rs2229238 0.868 rs73018293 chr1:154465577 C/T cg25273160 chr11:56955011 LRRC55 0.31 6.05 0.31 3.81e-9 Coronary heart disease; LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 14.09 0.61 1.09e-35 Platelet count; LUSC cis rs9660992 0.736 rs1180734 chr1:205255438 A/G cg21643547 chr1:205240462 TMCC2 -0.46 -8.63 -0.43 2.52e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg01570182 chr17:44337453 NA 0.69 10.39 0.49 4.39e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs12134245 0.874 rs35115044 chr1:92021650 A/G cg21854759 chr1:92012499 NA -0.41 -6.56 -0.34 2.02e-10 Breast cancer; LUSC cis rs1801251 1.000 rs6738386 chr2:233602028 T/C cg08000102 chr2:233561755 GIGYF2 0.69 11.43 0.53 9.1e-26 Coronary artery disease; LUSC cis rs4595586 0.525 rs73096109 chr12:39355720 C/A cg13010199 chr12:38710504 ALG10B 0.45 6.38 0.33 5.74e-10 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14487680 chr2:3381855 TSSC1 0.47 6.37 0.33 6.36e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg08888203 chr3:10149979 C3orf24 0.66 8.6 0.43 3.06e-16 Alzheimer's disease; LUSC cis rs6987853 0.814 rs2167338 chr8:42455079 A/G cg09913449 chr8:42400586 C8orf40 0.42 7.06 0.36 9.67e-12 Mean corpuscular hemoglobin concentration; LUSC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg17971929 chr21:40555470 PSMG1 -0.66 -10.79 -0.51 1.8e-23 Cognitive function; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.1 0.41 1.06e-14 Prudent dietary pattern; LUSC cis rs76793172 1.000 rs10420834 chr19:46347542 G/T cg00442267 chr19:46317840 RSPH6A -0.49 -5.74 -0.3 2.17e-8 Eosinophil counts; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22320231 chr17:28903436 LRRC37B2 0.39 5.99 0.31 5.39e-9 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg08859206 chr1:53392774 SCP2 -0.54 -9.41 -0.46 8.07e-19 Monocyte count; LUSC cis rs1030877 0.515 rs1020064 chr2:105897740 T/G cg02079111 chr2:105885981 TGFBRAP1 0.67 9.22 0.45 3.35e-18 Obesity-related traits; LUSC cis rs1568889 1.000 rs34140872 chr11:28335872 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 8.84 0.44 5.58e-17 Bipolar disorder; LUSC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.29 -0.41 2.78e-15 Intelligence (multi-trait analysis); LUSC cis rs2274273 0.743 rs13379159 chr14:55540801 C/T cg04306507 chr14:55594613 LGALS3 0.5 10.72 0.51 3.17e-23 Protein biomarker; LUSC cis rs1059312 1.000 rs7302634 chr12:129279931 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.69 -10.93 -0.51 5.6e-24 Systemic lupus erythematosus; LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg08027265 chr7:2291960 NA -0.38 -6.29 -0.33 9.98e-10 Bipolar disorder and schizophrenia; LUSC cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.26 -0.37 2.66e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18404974 chr22:18560667 PEX26 -0.42 -6.34 -0.33 7.34e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.7 -9.14 -0.45 5.99e-18 Schizophrenia; LUSC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg07424592 chr7:64974309 NA 0.66 5.8 0.3 1.55e-8 Diabetic kidney disease; LUSC cis rs231513 0.954 rs231504 chr17:41970906 C/G cg26893861 chr17:41843967 DUSP3 -0.51 -6.17 -0.32 1.97e-9 Cognitive function; LUSC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg00645731 chr22:42541494 CYP2D7P1 0.29 5.79 0.3 1.65e-8 Cognitive function; LUSC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg11764359 chr7:65958608 NA -0.79 -12.87 -0.58 4.64e-31 Aortic root size; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14986359 chr19:59085030 MZF1;LOC100131691 0.41 6.79 0.35 5.24e-11 Triglycerides; LUSC trans rs61931739 0.533 rs4270002 chr12:34313126 G/T cg13010199 chr12:38710504 ALG10B 0.4 6.33 0.33 7.75e-10 Morning vs. evening chronotype; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg04234412 chr22:24373322 LOC391322 0.92 16.5 0.67 3.83e-45 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7937890 0.967 rs963212 chr11:14324732 A/G cg19336497 chr11:14380999 RRAS2 0.45 8.13 0.41 8.49e-15 Mitochondrial DNA levels; LUSC cis rs1355223 1.000 rs11601205 chr11:34768479 C/T cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.94 -0.31 7.22e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg18404041 chr3:52824283 ITIH1 -0.57 -11.03 -0.52 2.41e-24 Bipolar disorder; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.81 0.43 6.92e-17 Prudent dietary pattern; LUSC cis rs7208859 0.623 rs7503335 chr17:29073962 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg16325326 chr1:53192061 ZYG11B -0.92 -17.21 -0.69 5.71e-48 Monocyte count; LUSC cis rs6545883 0.868 rs6752938 chr2:61841588 C/T cg15711740 chr2:61764176 XPO1 -0.43 -6.78 -0.35 5.57e-11 Tuberculosis; LUSC cis rs55986470 0.763 rs6739251 chr2:239419603 A/G cg18131467 chr2:239335373 ASB1 -0.61 -7.05 -0.36 1.01e-11 Chronotype; LUSC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg20976159 chr1:228193529 WNT3A 0.28 5.79 0.3 1.59e-8 Diastolic blood pressure; LUSC cis rs17253792 0.822 rs74653073 chr14:56079528 T/C cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.56 0.42 4.3e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg11752832 chr7:134001865 SLC35B4 0.52 7.78 0.39 8.94e-14 Mean platelet volume; LUSC cis rs1335645 0.570 rs2278578 chr1:111659792 G/T cg00321911 chr1:111669324 DRAM2 -0.6 -6.84 -0.35 3.88e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1008375 1.000 rs11947857 chr4:17691047 T/C cg04450456 chr4:17643702 FAM184B -0.39 -6.44 -0.33 4.26e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs61990749 0.597 rs176943 chr14:78175797 T/G cg02301378 chr14:78227641 SNW1;C14orf178 -0.61 -6.48 -0.33 3.33e-10 Fibroblast growth factor basic levels; LUSC cis rs554111 0.613 rs1567128 chr1:21404653 G/A cg01072550 chr1:21505969 NA 0.38 5.79 0.3 1.58e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs6598955 0.543 rs6690461 chr1:26543097 T/A cg12744634 chr1:26560303 CCDC21 0.39 5.84 0.3 1.25e-8 Obesity-related traits; LUSC cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg01884057 chr2:25150051 NA 0.48 11.49 0.53 5.56e-26 Body mass index; LUSC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg19077165 chr18:44547161 KATNAL2 0.38 5.8 0.3 1.55e-8 Personality dimensions; LUSC cis rs460214 0.564 rs9979888 chr21:40022099 A/G cg21578987 chr21:40029669 ERG -0.42 -6.67 -0.34 1.09e-10 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs654950 0.875 rs687766 chr1:41998849 C/G cg06885757 chr1:42089581 HIVEP3 0.34 6.44 0.33 4.14e-10 Airway imaging phenotypes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24378597 chr1:179263242 SOAT1 -0.43 -6.3 -0.33 9.52e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23896874 chr8:21924512 EPB49 0.68 5.95 0.31 6.89e-9 Cognitive performance; LUSC cis rs9473147 0.543 rs9473122 chr6:47474962 C/T cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs10887741 0.690 rs12781358 chr10:89444367 C/T cg13926569 chr10:89418898 PAPSS2 0.28 5.91 0.31 8.62e-9 Exercise (leisure time); LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.42e-19 Prudent dietary pattern; LUSC cis rs2540226 0.935 rs2373689 chr2:39987287 C/T cg23576258 chr2:39999331 THUMPD2 0.35 5.97 0.31 6.04e-9 Personality dimensions; LUSC cis rs7605827 0.897 rs34191114 chr2:15670691 C/A cg19274914 chr2:15703543 NA 0.47 9.22 0.45 3.46e-18 Educational attainment (years of education); LUSC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1007190 0.881 rs34854300 chr17:42969013 T/C cg15406952 chr17:42872593 NA 0.56 5.76 0.3 1.88e-8 DNA methylation (variation); LUSC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg04287289 chr16:89883240 FANCA -0.42 -6.02 -0.31 4.61e-9 Vitiligo; LUSC cis rs4971059 0.629 rs12904 chr1:155106697 G/A cg22049894 chr1:155113146 DPM3 0.39 6.19 0.32 1.79e-9 Breast cancer; LUSC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC trans rs208520 0.526 rs2881644 chr6:66803535 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.21 25.35 0.81 8.33e-80 Exhaled nitric oxide output; LUSC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg21862992 chr11:68658383 NA 0.51 8.3 0.41 2.58e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11864453 0.647 rs2550035 chr16:72113416 C/G cg01557791 chr16:72042693 DHODH -0.45 -6.67 -0.34 1.07e-10 Fibrinogen levels; LUSC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg10053473 chr17:62856997 LRRC37A3 0.67 10.61 0.5 7.58e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9462027 0.606 rs412392 chr6:34549699 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.97 -0.31 6.08e-9 Systemic lupus erythematosus; LUSC cis rs9611519 0.828 rs28814423 chr22:41452301 G/A cg13813247 chr22:41461852 NA -0.38 -6.77 -0.35 5.83e-11 Neuroticism; LUSC cis rs61931739 0.534 rs10844816 chr12:34248533 C/A cg06521331 chr12:34319734 NA -0.48 -7.86 -0.4 5.33e-14 Morning vs. evening chronotype; LUSC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg21665744 chr7:39171113 POU6F2 0.47 7.56 0.38 3.96e-13 IgG glycosylation; LUSC cis rs17292804 0.506 rs71417868 chr14:104046592 A/T cg08213375 chr14:104286397 PPP1R13B 0.35 5.99 0.31 5.55e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7937682 0.921 rs7130753 chr11:111470567 C/T cg09085632 chr11:111637200 PPP2R1B 0.97 13.84 0.6 9.19e-35 Primary sclerosing cholangitis; LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg14893161 chr1:205819251 PM20D1 -0.56 -8.93 -0.44 2.85e-17 Menarche (age at onset); LUSC cis rs3815700 1.000 rs10404211 chr19:33093565 C/T cg02997394 chr19:33096574 ANKRD27 0.71 7.11 0.36 7e-12 Eosinophilic esophagitis; LUSC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg24209194 chr3:40518798 ZNF619 0.48 6.2 0.32 1.64e-9 Renal cell carcinoma; LUSC trans rs6869502 0.871 rs13354207 chr5:110151791 C/G cg00576301 chr13:36920965 SPG20 -0.46 -6.23 -0.32 1.4e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.46e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs754466 0.580 rs11002293 chr10:79537965 C/T cg17075019 chr10:79541650 NA -0.78 -12.39 -0.56 2.86e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2439831 0.867 rs2243434 chr15:43689867 A/T cg02155558 chr15:43621948 ADAL;LCMT2 1.05 12.79 0.57 9.56e-31 Lung cancer in ever smokers; LUSC cis rs595982 0.527 rs56021835 chr19:49369989 G/A cg15549821 chr19:49342101 PLEKHA4 -0.58 -7.83 -0.39 6.38e-14 Red cell distribution width; LUSC cis rs2274273 0.901 rs12050099 chr14:55764331 G/C cg04306507 chr14:55594613 LGALS3 0.54 12.17 0.55 1.88e-28 Protein biomarker; LUSC cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg12165864 chr7:66369176 NA -0.51 -6.94 -0.35 2.06e-11 Corneal structure; LUSC trans rs12579753 0.810 rs1922565 chr12:82135348 T/C cg07923666 chr12:49932857 KCNH3 -0.51 -6.41 -0.33 4.85e-10 Resting heart rate; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg09436375 chr6:42928200 GNMT -0.27 -6.16 -0.32 2.14e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs61931739 0.500 rs10844829 chr12:34304916 G/T cg06521331 chr12:34319734 NA -0.47 -7.79 -0.39 8.31e-14 Morning vs. evening chronotype; LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.56 0.65 2.01e-41 Platelet count; LUSC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -8.34 -0.42 1.94e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg22782873 chr19:19639568 YJEFN3 -0.43 -6.01 -0.31 4.87e-9 Bipolar disorder; LUSC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg18305652 chr10:134549665 INPP5A 0.45 6.55 0.34 2.2e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg05368731 chr17:41323189 NBR1 0.85 14.6 0.62 1.09e-37 Menopause (age at onset); LUSC cis rs4423214 0.879 rs10898144 chr11:71151540 A/T cg05163923 chr11:71159392 DHCR7 -0.67 -9.44 -0.46 6.53e-19 Vitamin D levels; LUSC cis rs10493773 0.532 rs1889919 chr1:86180034 A/G cg17807903 chr1:86174739 ZNHIT6 -0.52 -13.84 -0.6 9.31e-35 Urate levels in overweight individuals; LUSC cis rs7267979 0.933 rs2261109 chr20:25259200 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.74 0.75 5.32e-62 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg26127166 chr9:116812388 ZNF618 -0.36 -6.11 -0.32 2.72e-9 Breast cancer; LUSC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg25072359 chr17:41440525 NA 0.61 8.64 0.43 2.34e-16 Menopause (age at onset); LUSC cis rs62344088 1.000 rs13436694 chr5:122882 A/T cg22857025 chr5:266934 NA -0.99 -7.12 -0.36 6.61e-12 Asthma (childhood onset); LUSC cis rs7605827 0.930 rs1035246 chr2:15512891 G/A cg19274914 chr2:15703543 NA 0.46 8.89 0.44 3.98e-17 Educational attainment (years of education); LUSC cis rs3820928 0.648 rs1997484 chr2:227898962 T/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.8 -0.39 7.86e-14 Pulmonary function; LUSC cis rs9300255 0.544 rs1716157 chr12:123670473 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.43 0.33 4.36e-10 Neutrophil percentage of white cells; LUSC cis rs2120243 0.874 rs2316706 chr3:157160061 A/C cg01018701 chr3:157155998 VEPH1;PTX3 0.38 6.18 0.32 1.86e-9 Hepatocellular carcinoma in hepatitis B infection; LUSC trans rs61931739 0.534 rs1586410 chr12:33999142 C/T cg26384229 chr12:38710491 ALG10B 0.74 11.5 0.53 5.04e-26 Morning vs. evening chronotype; LUSC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg27266060 chr8:22091797 NA 0.39 7.15 0.36 5.38e-12 Hypertriglyceridemia; LUSC cis rs7539409 0.651 rs6696140 chr1:84317468 C/T cg10977910 chr1:84465055 TTLL7 -0.74 -7.89 -0.4 4.24e-14 Alzheimer's disease; LUSC trans rs853679 0.517 rs16893666 chr6:28054707 C/T cg06606381 chr12:133084897 FBRSL1 0.44 6.06 0.31 3.71e-9 Depression; LUSC cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg03684893 chr10:554711 DIP2C -0.39 -7.09 -0.36 7.89e-12 Psychosis in Alzheimer's disease; LUSC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg09509183 chr1:209979624 IRF6 0.5 6.02 0.31 4.57e-9 Cleft lip with or without cleft palate; LUSC cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg08754478 chr10:133766260 PPP2R2D -0.61 -7.73 -0.39 1.26e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2562456 0.755 rs2650773 chr19:21644088 A/G cg00806126 chr19:22604979 ZNF98 0.39 6.02 0.31 4.47e-9 Pain; LUSC cis rs6964587 0.935 rs28412174 chr7:91577245 T/G cg17063962 chr7:91808500 NA -0.57 -8.98 -0.44 2.05e-17 Breast cancer; LUSC cis rs2274273 0.967 rs17832359 chr14:55615941 T/C cg04306507 chr14:55594613 LGALS3 0.55 12.09 0.55 3.69e-28 Protein biomarker; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg18099408 chr3:52552593 STAB1 -0.44 -6.97 -0.36 1.74e-11 Bipolar disorder; LUSC cis rs9300255 0.698 rs4759416 chr12:123746357 C/G cg05973401 chr12:123451056 ABCB9 0.52 6.49 0.33 3.19e-10 Neutrophil percentage of white cells; LUSC cis rs2230307 0.536 rs482466 chr1:100488177 C/T cg24955406 chr1:100503596 HIAT1 0.57 6.17 0.32 1.95e-9 Carotid intima media thickness; LUSC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs7568458 0.709 rs2028898 chr2:85777270 G/A cg23752985 chr2:85803571 VAMP8 0.33 6.36 0.33 6.62e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.71 0.47 8.46e-20 Bipolar disorder; LUSC cis rs250677 0.958 rs36067 chr5:148417553 T/G cg12140854 chr5:148520817 ABLIM3 -0.36 -5.88 -0.31 9.93e-9 Breast cancer; LUSC cis rs9905704 0.627 rs1267543 chr17:56656624 A/G cg12560992 chr17:57184187 TRIM37 -0.53 -6.34 -0.33 7.56e-10 Testicular germ cell tumor; LUSC cis rs56283067 0.847 rs10456536 chr6:44692995 G/C cg18551225 chr6:44695536 NA -0.49 -8.27 -0.41 3.22e-15 Total body bone mineral density; LUSC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs73198271 0.531 rs17154758 chr8:8653343 G/A cg01851573 chr8:8652454 MFHAS1 0.59 7.77 0.39 9.84e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs11098499 0.865 rs11098513 chr4:120316075 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.0 0.31 5.14e-9 Corneal astigmatism; LUSC cis rs12200560 0.505 rs211164 chr6:97068140 G/T cg06623918 chr6:96969491 KIAA0776 0.49 7.03 0.36 1.2e-11 Coronary heart disease; LUSC trans rs2797160 0.967 rs1578793 chr6:126015057 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.88 0.35 2.9e-11 Endometrial cancer; LUSC cis rs6754311 0.731 rs12615624 chr2:136721603 A/G cg07169764 chr2:136633963 MCM6 0.68 9.86 0.47 2.7e-20 Mosquito bite size; LUSC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg26513180 chr16:89883248 FANCA 0.76 5.99 0.31 5.4e-9 Skin colour saturation; LUSC cis rs7264396 0.623 rs6060507 chr20:34198334 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -7.16 -0.36 5.13e-12 Total cholesterol levels; LUSC cis rs11098499 0.913 rs56122576 chr4:120129336 A/G cg24375607 chr4:120327624 NA 0.72 10.67 0.5 4.5e-23 Corneal astigmatism; LUSC cis rs4948102 0.732 rs6951810 chr7:56076598 T/C cg17215666 chr7:56131930 SUMF2 0.46 5.85 0.31 1.15e-8 Plasma homocysteine levels (post-methionine load test); LUSC trans rs11039798 0.764 rs10838882 chr11:48393035 T/A cg03929089 chr4:120376271 NA 0.64 5.98 0.31 5.65e-9 Axial length; LUSC cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg13175981 chr1:150552382 MCL1 0.43 6.13 0.32 2.49e-9 Tonsillectomy; LUSC cis rs1003719 0.715 rs2835639 chr21:38537016 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.56e-22 Eye color traits; LUSC cis rs7833986 0.818 rs79824205 chr8:57093233 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.63 9.35 0.46 1.28e-18 Height; LUSC cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.13 0.41 8.45e-15 Axial length; LUSC trans rs11039798 0.920 rs9667596 chr11:48691193 T/C cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC cis rs4812048 0.649 rs3761255 chr20:57618802 T/C cg14073986 chr20:57617431 SLMO2 0.88 9.51 0.46 3.89e-19 Mean platelet volume; LUSC cis rs7312933 0.558 rs11181501 chr12:42822671 G/A cg01256987 chr12:42539512 GXYLT1 -0.39 -7.15 -0.36 5.43e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7123876 0.504 rs1157343 chr11:72429141 A/G cg03713592 chr11:72463424 ARAP1 -0.45 -6.12 -0.32 2.56e-9 Body mass index; LUSC cis rs25645 0.830 rs4072639 chr17:38189049 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.66 11.48 0.53 6.18e-26 Myeloid white cell count; LUSC cis rs3768617 0.811 rs6424883 chr1:183037695 T/C ch.1.3577855R chr1:183094577 LAMC1 0.6 8.64 0.43 2.29e-16 Fuchs's corneal dystrophy; LUSC cis rs6940638 0.688 rs9295730 chr6:27128806 T/C cg12826209 chr6:26865740 GUSBL1 0.53 7.56 0.38 4.03e-13 Intelligence (multi-trait analysis); LUSC cis rs4516970 0.826 rs59246098 chr6:160149462 C/CA cg25736982 chr6:160182554 ACAT2 0.67 9.45 0.46 6.17e-19 Iron status biomarkers; LUSC cis rs2046867 0.818 rs2208 chr3:72871773 A/G cg25664220 chr3:72788482 NA 0.68 12.12 0.55 2.79e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.06 -0.31 3.67e-9 Alzheimer's disease (late onset); LUSC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11890956 chr21:40555474 PSMG1 -0.84 -14.63 -0.63 8.26e-38 Cognitive function; LUSC trans rs561341 1.000 rs546748 chr17:30324293 A/C cg20587970 chr11:113659929 NA -1.04 -13.97 -0.61 3.13e-35 Hip circumference adjusted for BMI; LUSC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg06212747 chr3:49208901 KLHDC8B 0.44 6.1 0.32 2.92e-9 Parkinson's disease; LUSC cis rs9929218 0.551 rs2296405 chr16:68721470 C/T cg01251360 chr16:68772225 CDH1 0.25 6.07 0.32 3.46e-9 Colorectal cancer; LUSC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg17507749 chr15:85114479 UBE2QP1 0.69 8.7 0.43 1.56e-16 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16761131 chr22:38142377 TRIOBP -0.42 -6.27 -0.32 1.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg06112835 chr11:68658793 MRPL21 0.52 8.0 0.4 2.08e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg08999081 chr20:33150536 PIGU 0.52 10.42 0.5 3.46e-22 Glomerular filtration rate (creatinine); LUSC cis rs2777491 0.874 rs13379756 chr15:41663896 A/C cg18705301 chr15:41695430 NDUFAF1 -0.71 -12.65 -0.57 3.15e-30 Ulcerative colitis; LUSC cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.96 0.4 2.72e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2658782 0.724 rs2658769 chr11:93252030 T/C cg15737290 chr11:93063684 CCDC67 0.6 7.2 0.37 4.13e-12 Pulmonary function decline; LUSC cis rs1784581 1.000 rs1784581 chr6:162401127 A/C cg17173639 chr6:162384350 PARK2 -0.81 -14.73 -0.63 3.48e-38 Itch intensity from mosquito bite; LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg25036284 chr2:26402008 FAM59B 0.72 10.36 0.49 5.33e-22 Gut microbiome composition (summer); LUSC trans rs2204008 0.777 rs6582664 chr12:37947022 A/G cg06521331 chr12:34319734 NA 0.4 6.34 0.33 7.28e-10 Bladder cancer; LUSC cis rs7264396 0.790 rs6060519 chr20:34217383 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.69 -0.47 9.75e-20 Total cholesterol levels; LUSC cis rs9653442 0.648 rs6733895 chr2:100666082 C/G cg22139774 chr2:100720529 AFF3 -0.48 -8.28 -0.41 2.96e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs870825 0.587 rs35377170 chr4:185639728 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs554111 0.634 rs7551785 chr1:21524297 C/G cg01072550 chr1:21505969 NA -0.4 -6.0 -0.31 5.25e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs9811920 0.555 rs68092024 chr3:99691522 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -7.45 -0.38 8.04e-13 Axial length; LUSC cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg16797656 chr11:68205561 LRP5 0.35 5.87 0.31 1.08e-8 Total body bone mineral density; LUSC cis rs6736093 1.000 rs17779482 chr2:112665677 C/T cg12686935 chr2:112915763 FBLN7 -0.35 -5.74 -0.3 2.1e-8 Coronary artery disease; LUSC cis rs11608355 1.000 rs2075439 chr12:109859374 A/G cg19025524 chr12:109796872 NA -0.38 -6.01 -0.31 4.76e-9 Neuroticism; LUSC cis rs7267979 0.966 rs416745 chr20:25438868 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg13256891 chr4:100009986 ADH5 0.52 7.21 0.37 3.67e-12 Smoking initiation; LUSC cis rs7106204 0.514 rs10834307 chr11:24272516 G/A ch.11.24196551F chr11:24239977 NA -0.9 -9.82 -0.47 3.71e-20 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2348418 0.864 rs11609924 chr12:28716130 G/A cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg26380479 chr7:97908229 NA -0.27 -5.86 -0.31 1.13e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs2050392 0.965 rs2265370 chr10:30690581 C/T cg18806716 chr10:30721971 MAP3K8 -0.44 -7.15 -0.36 5.54e-12 Inflammatory bowel disease; LUSC cis rs597539 0.521 rs7943745 chr11:68605828 A/G cg06112835 chr11:68658793 MRPL21 -0.38 -6.29 -0.33 9.85e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg13628971 chr7:2884303 GNA12 0.39 5.94 0.31 7.19e-9 Height; LUSC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg19077165 chr18:44547161 KATNAL2 -0.4 -5.84 -0.3 1.21e-8 Personality dimensions; LUSC trans rs11764590 0.671 rs56226325 chr7:2078981 C/T cg25206134 chr2:45395956 NA 0.6 6.51 0.34 2.73e-10 Neuroticism; LUSC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg17554472 chr22:41940697 POLR3H -0.48 -5.94 -0.31 7.14e-9 Vitiligo; LUSC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg00129232 chr17:37814104 STARD3 -0.53 -7.96 -0.4 2.75e-14 Asthma; LUSC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg11812906 chr14:75593930 NEK9 -0.63 -10.63 -0.5 6.15e-23 Height; LUSC cis rs17253792 0.822 rs80328469 chr14:56067701 G/A cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg18132916 chr6:79620363 NA -0.4 -6.13 -0.32 2.43e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg22535103 chr8:58192502 C8orf71 -0.58 -6.86 -0.35 3.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg07362569 chr17:61921086 SMARCD2 0.36 7.13 0.36 6.16e-12 Prudent dietary pattern; LUSC cis rs9646954 0.542 rs4149505 chr2:101033697 G/A cg08017756 chr2:100939284 LONRF2 -0.48 -9.06 -0.44 1.09e-17 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg08280861 chr8:58055591 NA 0.54 6.14 0.32 2.31e-9 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg16339924 chr4:17578868 LAP3 0.58 8.68 0.43 1.74e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6547741 0.935 rs56001553 chr2:27859926 C/T cg12559939 chr2:27858050 GPN1 -0.4 -6.13 -0.32 2.48e-9 Oral cavity cancer; LUSC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg04727924 chr7:799746 HEATR2 -0.51 -6.04 -0.31 4.11e-9 Cerebrospinal P-tau181p levels; LUSC trans rs6601327 0.602 rs7820917 chr8:9647868 C/T cg06636001 chr8:8085503 FLJ10661 0.51 7.53 0.38 4.64e-13 Multiple myeloma (hyperdiploidy); LUSC cis rs4727027 0.704 rs12704071 chr7:148904795 C/T cg23583168 chr7:148888333 NA -0.89 -17.77 -0.7 3.37e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs13221852 0.659 rs1554502 chr7:3418411 C/T cg21248987 chr7:3385318 SDK1 0.36 6.03 0.31 4.36e-9 Acute graft versus host disease in bone marrow transplantation (donor effect); LUSC cis rs7539542 0.577 rs6662398 chr1:202888456 T/G cg19681188 chr1:202830198 LOC148709 0.41 6.08 0.32 3.21e-9 Mean platelet volume; LUSC cis rs4622329 0.572 rs7956803 chr12:102293862 T/G cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC cis rs35146811 0.735 rs7811662 chr7:99792608 A/G cg13334819 chr7:99746414 C7orf59 -0.51 -6.9 -0.35 2.61e-11 Coronary artery disease; LUSC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.56e-11 Total body bone mineral density; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 8.22e-43 Menopause (age at onset); LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg14004847 chr7:1930337 MAD1L1 0.52 7.66 0.39 2.02e-13 Bipolar disorder and schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02767470 chr2:152663031 ARL5A -0.43 -6.16 -0.32 2.03e-9 Triglycerides; LUSC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg07424592 chr7:64974309 NA -0.63 -5.68 -0.3 2.9e-8 Diabetic kidney disease; LUSC trans rs17039065 0.834 rs12499196 chr4:109425988 T/C cg07444054 chr2:108107501 NA 0.45 6.29 0.33 1.01e-9 Gut microbiome composition (summer); LUSC cis rs4704187 0.687 rs10051572 chr5:74502797 G/A cg03227963 chr5:74354835 NA 0.3 6.64 0.34 1.24e-10 Response to amphetamines; LUSC cis rs2294693 0.898 rs6458195 chr6:40972498 A/T cg14418226 chr6:40996092 UNC5CL -0.4 -5.82 -0.3 1.4e-8 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg25173405 chr17:45401733 C17orf57 -0.37 -5.72 -0.3 2.37e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg27494647 chr7:150038898 RARRES2 0.51 7.44 0.38 8.79e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs9473147 0.543 rs4715025 chr6:47483653 C/G cg20196966 chr6:47445060 CD2AP 0.41 5.79 0.3 1.66e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs6484504 0.576 rs158146 chr11:31210433 G/A cg26647111 chr11:31128758 NA -0.4 -5.79 -0.3 1.6e-8 Red blood cell count; LUSC cis rs3812831 0.629 rs7318527 chr13:114946956 C/T cg08824895 chr13:115047677 UPF3A 0.56 8.8 0.43 7.46e-17 Schizophrenia; LUSC cis rs754466 0.606 rs11002308 chr10:79594796 A/T cg17075019 chr10:79541650 NA -0.78 -12.51 -0.56 1.02e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs701145 0.529 rs355746 chr3:153961627 C/G cg10247383 chr3:153839028 SGEF -0.5 -6.11 -0.32 2.79e-9 Coronary artery disease; LUSC cis rs9796 0.840 rs1009913 chr15:41331050 C/T cg18705301 chr15:41695430 NDUFAF1 0.44 7.83 0.39 6.54e-14 Menopause (age at onset); LUSC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg11247378 chr22:39784982 NA -0.65 -13.16 -0.58 3.8e-32 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg26513180 chr16:89883248 FANCA 0.51 7.69 0.39 1.65e-13 Vitiligo; LUSC cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg22496339 chr2:162101262 NA 0.52 7.56 0.38 3.9e-13 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.77 0.35 5.79e-11 Lung cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09419983 chr3:148847273 HPS3 0.75 6.37 0.33 6.12e-10 Cognitive performance; LUSC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg05585544 chr11:47624801 NA 0.41 7.19 0.37 4.39e-12 Subjective well-being; LUSC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg10909506 chr17:38081995 ORMDL3 0.35 6.16 0.32 2.11e-9 Self-reported allergy; LUSC cis rs9921338 0.961 rs12934968 chr16:11414066 C/A cg00044050 chr16:11439710 C16orf75 0.5 6.71 0.34 8.3e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg03433033 chr1:76189801 ACADM 0.73 9.65 0.47 1.39e-19 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs2018683 0.677 rs2057956 chr7:28973460 G/A cg19402173 chr7:128379420 CALU -0.47 -7.08 -0.36 8.32e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs7937682 0.575 rs10789851 chr11:111750955 G/C cg09085632 chr11:111637200 PPP2R1B 0.96 13.34 0.59 8.01e-33 Primary sclerosing cholangitis; LUSC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg02782426 chr3:40428986 ENTPD3 0.32 6.04 0.31 4.03e-9 Renal cell carcinoma; LUSC cis rs11864453 1.000 rs2278027 chr16:72051369 A/G cg01557791 chr16:72042693 DHODH -0.56 -8.49 -0.42 6.84e-16 Fibrinogen levels; LUSC cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.33 0.33 7.68e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7582180 0.629 rs12991172 chr2:100941671 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.89e-8 Intelligence (multi-trait analysis); LUSC cis rs9341808 0.754 rs10733162 chr6:81023389 G/A cg08355045 chr6:80787529 NA 0.56 9.73 0.47 7.43e-20 Sitting height ratio; LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.7 0.39 1.61e-13 Prudent dietary pattern; LUSC cis rs6964587 1.000 rs6969981 chr7:91689461 G/C cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.38 0.59 5.5e-33 Platelet count; LUSC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs6977660 0.660 rs10253753 chr7:19823032 A/G cg07541023 chr7:19748670 TWISTNB 0.58 6.24 0.32 1.34e-9 Thyroid stimulating hormone; LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.22 0.61 3.35e-36 Platelet count; LUSC cis rs1957429 0.614 rs76809238 chr14:65380579 C/T cg23373153 chr14:65346875 NA -0.98 -7.73 -0.39 1.3e-13 Pediatric areal bone mineral density (radius); LUSC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg20135002 chr11:47629003 NA -0.48 -7.51 -0.38 5.38e-13 Subjective well-being; LUSC cis rs9902453 0.765 rs3115087 chr17:28030267 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.28 0.45 2.14e-18 Coffee consumption (cups per day); LUSC cis rs2073300 1.000 rs74273799 chr20:23444492 T/C cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs17155006 0.638 rs2074747 chr7:107744735 G/A cg05962710 chr7:107745446 LAMB4 -0.35 -6.13 -0.32 2.52e-9 Pneumococcal bacteremia; LUSC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg15839431 chr19:19639596 YJEFN3 -0.43 -6.13 -0.32 2.5e-9 Tonsillectomy; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg07677032 chr17:61819896 STRADA 0.55 8.97 0.44 2.24e-17 Prudent dietary pattern; LUSC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg19729930 chr2:74357872 NA 0.93 17.57 0.69 2.03e-49 Gestational age at birth (maternal effect); LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg16405210 chr4:1374714 KIAA1530 0.55 8.35 0.42 1.81e-15 Obesity-related traits; LUSC cis rs3857536 0.813 rs6455090 chr6:66948909 G/A cg07460842 chr6:66804631 NA -0.46 -6.41 -0.33 5.04e-10 Blood trace element (Cu levels); LUSC cis rs6547741 1.000 rs11127071 chr2:27838058 C/A cg27432699 chr2:27873401 GPN1 0.8 14.94 0.63 5.09e-39 Oral cavity cancer; LUSC cis rs1784581 0.802 rs9365355 chr6:162414604 A/G cg17173639 chr6:162384350 PARK2 0.66 11.84 0.54 3.02e-27 Itch intensity from mosquito bite; LUSC cis rs2280018 0.526 rs1510148 chr16:15167379 T/A cg27102117 chr16:15229624 NA 0.52 8.12 0.41 8.86e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9733 0.650 rs12406712 chr1:150545084 C/A cg13175981 chr1:150552382 MCL1 0.48 6.55 0.34 2.12e-10 Tonsillectomy; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg22907277 chr7:1156413 C7orf50 0.49 7.43 0.38 9.12e-13 Longevity;Endometriosis; LUSC cis rs1395 0.744 rs11126932 chr2:27476282 G/A cg23587288 chr2:27483067 SLC30A3 -0.29 -5.7 -0.3 2.61e-8 Blood metabolite levels; LUSC cis rs2731664 0.792 rs335466 chr5:176889530 C/A cg23176889 chr5:176863531 GRK6 -0.66 -13.43 -0.59 3.5e-33 Intelligence (multi-trait analysis); LUSC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg19901468 chr14:105411992 AHNAK2 -0.71 -12.52 -0.57 9.7e-30 Rheumatoid arthritis; LUSC cis rs4629180 0.675 rs6707298 chr2:102089738 A/G cg01388757 chr2:102091195 RFX8 0.36 6.26 0.32 1.16e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs6138458 1.000 rs1977540 chr20:24900290 G/T cg26195577 chr20:24973756 C20orf3 -1.12 -18.25 -0.71 4.21e-52 Blood protein levels; LUSC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg00815214 chr21:47717953 NA 0.42 6.62 0.34 1.45e-10 Testicular germ cell tumor; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg08200582 chr11:442649 ANO9 -0.52 -6.02 -0.31 4.59e-9 Body mass index; LUSC cis rs9420 1.000 rs543725 chr11:57483039 A/T cg02958346 chr11:57425731 CLP1 -0.41 -6.04 -0.31 4.19e-9 Schizophrenia; LUSC trans rs7829975 0.509 rs7838674 chr8:8797073 A/T cg21775007 chr8:11205619 TDH -0.41 -6.22 -0.32 1.49e-9 Mood instability; LUSC trans rs71435601 0.600 rs502323 chr2:21403297 A/C cg20757404 chr19:378427 NA 0.38 6.02 0.31 4.71e-9 Cholesterol, total; LUSC trans rs35110281 0.667 rs2838354 chr21:45119857 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.57 0.5 1.01e-22 Mean corpuscular volume; LUSC trans rs7824557 0.606 rs1435277 chr8:11196970 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.04 0.4 1.62e-14 Retinal vascular caliber; LUSC cis rs4727027 0.704 rs12704083 chr7:148909759 G/A cg14690467 chr7:148917905 ZNF282 -0.26 -5.74 -0.3 2.1e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6964587 0.967 rs34863529 chr7:91644341 C/G cg22709100 chr7:91322751 NA 0.43 6.25 0.32 1.26e-9 Breast cancer; LUSC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.87 0.35 3.24e-11 Schizophrenia; LUSC cis rs7818345 0.935 rs4333618 chr8:19283442 G/C cg11303988 chr8:19266685 CSGALNACT1 0.39 7.48 0.38 6.81e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg24642439 chr20:33292090 TP53INP2 -0.64 -10.2 -0.49 1.95e-21 Coronary artery disease; LUSC cis rs4595586 0.525 rs7968458 chr12:39377139 C/A cg13010199 chr12:38710504 ALG10B 0.41 5.92 0.31 7.89e-9 Morning vs. evening chronotype; LUSC cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.5 -7.59 -0.38 3.2e-13 Menarche (age at onset); LUSC trans rs4332037 0.950 rs7807014 chr7:1939021 T/C cg11693508 chr17:37793320 STARD3 0.64 7.76 0.39 1.05e-13 Bipolar disorder; LUSC cis rs12421382 0.659 rs1439511 chr11:109392839 G/T cg27471124 chr11:109292789 C11orf87 -0.49 -8.0 -0.4 2.06e-14 Schizophrenia; LUSC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.22e-10 Aortic root size; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27067269 chr10:48355070 ZNF488 0.45 5.98 0.31 5.85e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4954585 0.708 rs13034241 chr2:137021263 G/A cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.67e-13 Colorectal cancer; LUSC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.82 -0.47 3.8e-20 Gut microbiome composition (summer); LUSC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg16339924 chr4:17578868 LAP3 0.51 7.86 0.4 5.4e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg10729496 chr3:10149963 C3orf24 0.54 7.06 0.36 9.62e-12 Alzheimer's disease; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg16362232 chr11:430036 ANO9 0.66 8.29 0.41 2.74e-15 Body mass index; LUSC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg15001381 chr16:403314 AXIN1 0.33 5.96 0.31 6.56e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs1832871 0.711 rs62439861 chr6:158700531 A/G cg07165851 chr6:158734300 TULP4 0.5 7.78 0.39 9.42e-14 Height; LUSC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg00255919 chr5:131827918 IRF1 -0.41 -7.71 -0.39 1.41e-13 Asthma (sex interaction); LUSC trans rs8073060 0.544 rs225246 chr17:33944773 T/C cg19694781 chr19:47549865 TMEM160 -1.13 -18.17 -0.71 8.74e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs6502050 0.799 rs4789680 chr17:80100547 C/A cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs4819052 0.679 rs2838859 chr21:46684517 C/T cg11663144 chr21:46675770 NA -0.32 -5.66 -0.3 3.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg15448220 chr1:150897856 SETDB1 0.42 6.1 0.32 2.93e-9 Melanoma; LUSC cis rs3099143 1.000 rs3110381 chr15:77099665 A/T cg21673338 chr15:77095150 SCAPER -0.8 -7.78 -0.39 9.39e-14 Recalcitrant atopic dermatitis; LUSC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7909074 1.000 rs10751361 chr10:45398186 C/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.71 -0.43 1.42e-16 Mean corpuscular volume; LUSC cis rs2797160 0.904 rs1418637 chr6:125992553 A/G cg05901451 chr6:126070800 HEY2 -0.59 -9.15 -0.45 5.68e-18 Endometrial cancer; LUSC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg04369109 chr6:150039330 LATS1 -0.53 -7.3 -0.37 2.15e-12 Lung cancer; LUSC cis rs62458065 1.000 rs979355 chr7:32463933 A/G cg20159608 chr7:32802032 NA 0.55 6.81 0.35 4.59e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7954584 0.567 rs11043243 chr12:122356370 G/C cg10207240 chr12:122356781 WDR66 0.46 6.45 0.33 3.84e-10 Mean corpuscular volume; LUSC trans rs11098499 1.000 rs12506395 chr4:120185094 C/T cg25214090 chr10:38739885 LOC399744 0.46 6.63 0.34 1.34e-10 Corneal astigmatism; LUSC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg14552801 chr7:65878734 NA -0.36 -5.68 -0.3 2.91e-8 Aortic root size; LUSC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.27e-11 Lung cancer; LUSC cis rs72634258 0.945 rs1883679 chr1:8100451 T/G cg00042356 chr1:8021962 PARK7 0.77 9.26 0.45 2.61e-18 Inflammatory bowel disease; LUSC cis rs554111 0.571 rs4537519 chr1:21461370 T/C cg01072550 chr1:21505969 NA 0.39 5.87 0.31 1.07e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC trans rs694739 0.628 rs645078 chr11:64135298 A/C cg20325517 chr11:96123557 JRKL;CCDC82 -0.43 -6.03 -0.31 4.34e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs2224391 0.955 rs2773322 chr6:5263065 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.46 -6.61 -0.34 1.55e-10 Height; LUSC cis rs7246967 0.673 rs35335083 chr19:22869592 A/C cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs9322193 0.567 rs7747457 chr6:150213502 T/A cg09699651 chr6:150184138 LRP11 0.45 7.07 0.36 9.31e-12 Lung cancer; LUSC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11676348 0.772 rs6738953 chr2:218950036 C/A cg18102446 chr2:218934044 RUFY4 0.35 5.66 0.3 3.31e-8 Ulcerative colitis; LUSC cis rs6582630 0.576 rs4882372 chr12:38356609 C/A cg26384229 chr12:38710491 ALG10B -0.55 -8.19 -0.41 5.56e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs6752107 0.935 rs10199278 chr2:234160669 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.71 11.91 0.55 1.74e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9467773 1.000 rs767471 chr6:26557854 C/T cg11502198 chr6:26597334 ABT1 0.63 9.95 0.48 1.31e-20 Intelligence (multi-trait analysis); LUSC cis rs11608355 0.846 rs12581637 chr12:109855429 G/A cg19025524 chr12:109796872 NA -0.39 -5.66 -0.3 3.33e-8 Neuroticism; LUSC cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg05234568 chr11:5960015 NA -0.53 -7.4 -0.38 1.13e-12 DNA methylation (variation); LUSC cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.86 -11.18 -0.52 7.15e-25 Chronic sinus infection; LUSC cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg27279351 chr12:120934652 DYNLL1 0.58 7.78 0.39 9.35e-14 High light scatter reticulocyte count; LUSC cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg06740227 chr12:86229804 RASSF9 0.4 6.38 0.33 5.89e-10 Major depressive disorder; LUSC cis rs12681287 0.608 rs13272148 chr8:87481853 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs920590 0.758 rs1826420 chr8:19664878 G/T cg03894339 chr8:19674705 INTS10 0.51 6.83 0.35 4.07e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg27170947 chr2:26402098 FAM59B -0.63 -9.1 -0.45 8.18e-18 Gut microbiome composition (summer); LUSC trans rs890100 0.642 rs1157475 chr2:56685562 G/C cg01657744 chr10:88471748 LDB3 0.44 5.97 0.31 6.13e-9 Gut microbiome composition (summer); LUSC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg12257692 chr3:49977190 RBM6 -0.26 -7.41 -0.38 1.03e-12 Body mass index; LUSC cis rs4423214 0.879 rs1630498 chr11:71150785 A/C cg05163923 chr11:71159392 DHCR7 -0.67 -9.0 -0.44 1.74e-17 Vitamin D levels; LUSC trans rs4332037 0.906 rs6461009 chr7:1952139 T/C cg11693508 chr17:37793320 STARD3 -0.63 -7.88 -0.4 4.56e-14 Bipolar disorder; LUSC cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.82 -0.43 6.4e-17 Personality dimensions; LUSC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.67 11.63 0.54 1.71e-26 Personality dimensions; LUSC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg16624210 chr5:671434 TPPP 0.5 6.2 0.32 1.63e-9 Lung disease severity in cystic fibrosis; LUSC cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg00999904 chr2:3704751 ALLC 0.46 7.52 0.38 5.01e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7336332 0.527 rs1475219 chr13:28037415 A/G cg22138327 chr13:27999177 GTF3A 0.66 8.69 0.43 1.62e-16 Weight; LUSC cis rs734999 0.545 rs10910105 chr1:2538209 G/A cg18932078 chr1:2524107 MMEL1 0.32 7.08 0.36 8.45e-12 Ulcerative colitis; LUSC cis rs73206853 0.620 rs112599609 chr12:111147643 C/T cg12870014 chr12:110450643 ANKRD13A 0.67 6.52 0.34 2.64e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2446066 0.520 rs34649330 chr12:53893031 C/T cg20730629 chr12:53886622 MAP3K12 -0.46 -5.99 -0.31 5.39e-9 Red blood cell count; LUSC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg25258033 chr6:167368657 RNASET2 -0.47 -7.78 -0.39 9.43e-14 Crohn's disease; LUSC cis rs714027 0.585 rs41157 chr22:30405151 T/C cg11564601 chr22:30592435 NA -0.35 -5.92 -0.31 7.84e-9 Lymphocyte counts; LUSC cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs67072384 1.000 rs67075228 chr11:72450775 C/T cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.4e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg20203395 chr5:56204925 C5orf35 0.57 8.24 0.41 4.09e-15 Initial pursuit acceleration; LUSC cis rs62432291 0.681 rs402388 chr6:159654994 A/C cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC trans rs61931739 0.546 rs61927758 chr12:33712017 T/C cg26384229 chr12:38710491 ALG10B -0.42 -6.12 -0.32 2.68e-9 Morning vs. evening chronotype; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13608629 chr2:70531203 NA 0.44 6.18 0.32 1.87e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs950027 0.620 rs1426932 chr15:45687256 T/C cg26924012 chr15:45694286 SPATA5L1 0.78 12.28 0.56 7.55e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs73001065 0.818 rs73004975 chr19:19727152 A/G cg03709012 chr19:19516395 GATAD2A 0.89 7.2 0.37 4.1e-12 LDL cholesterol; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10130860 chr1:43124230 PPIH 0.44 6.82 0.35 4.29e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11190604 1.000 rs2495754 chr10:102324812 C/T cg07080220 chr10:102295463 HIF1AN 0.7 8.86 0.44 4.77e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3809566 1.000 rs3809566 chr15:63333724 A/G cg00520135 chr15:63333846 TPM1 -0.34 -6.84 -0.35 3.88e-11 Platelet count; LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg25072359 chr17:41440525 NA 0.64 9.06 0.44 1.15e-17 Menopause (age at onset); LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -9.2 -0.45 3.89e-18 Platelet count; LUSC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg10802521 chr3:52805072 NEK4 -0.38 -5.77 -0.3 1.76e-8 Electroencephalogram traits; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg13986881 chr7:73669141 RFC2 0.4 6.31 0.33 8.81e-10 Schizophrenia; LUSC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.64 0.34 1.28e-10 Hip circumference adjusted for BMI; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.73 -0.57 1.58e-30 Alzheimer's disease; LUSC cis rs79149102 0.737 rs7163332 chr15:75193623 C/T cg09165964 chr15:75287851 SCAMP5 -0.79 -6.39 -0.33 5.6e-10 Lung cancer; LUSC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.69 0.47 1.01e-19 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs62400317 0.859 rs10948214 chr6:45170466 T/C cg20913747 chr6:44695427 NA -0.48 -7.69 -0.39 1.66e-13 Total body bone mineral density; LUSC cis rs921968 0.541 rs3755041 chr2:219442499 A/T cg02176678 chr2:219576539 TTLL4 -0.75 -14.52 -0.62 2.21e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs2839186 0.721 rs13051200 chr21:47701693 A/T cg12379764 chr21:47803548 PCNT -0.42 -5.96 -0.31 6.38e-9 Testicular germ cell tumor; LUSC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg24881330 chr22:46731750 TRMU 0.85 8.39 0.42 1.38e-15 LDL cholesterol;Cholesterol, total; LUSC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs7681440 0.874 rs1442154 chr4:90775761 C/G cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.23e-8 Dementia with Lewy bodies; LUSC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg14784868 chr12:69753453 YEATS4 0.64 9.59 0.46 2.07e-19 Blood protein levels; LUSC cis rs6500602 0.647 rs1684600 chr16:4594671 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.45 -5.95 -0.31 6.82e-9 Schizophrenia; LUSC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg11764359 chr7:65958608 NA -0.69 -10.74 -0.51 2.71e-23 Aortic root size; LUSC cis rs6977660 1.000 rs1468288 chr7:19810580 C/G cg05791153 chr7:19748676 TWISTNB 0.63 6.85 0.35 3.55e-11 Thyroid stimulating hormone; LUSC cis rs8056893 0.550 rs9923188 chr16:68311867 G/T cg02226672 chr16:68398533 SMPD3 0.29 5.67 0.3 3.06e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs2070488 0.965 rs7373828 chr3:38524311 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 13.27 0.59 1.48e-32 Electrocardiographic conduction measures; LUSC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg13126279 chr21:47581558 C21orf56 -0.46 -6.89 -0.35 2.85e-11 Testicular germ cell tumor; LUSC cis rs6495122 0.501 rs12904227 chr15:75387048 A/C cg10253484 chr15:75165896 SCAMP2 0.41 5.84 0.3 1.22e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs3754214 0.823 rs496203 chr1:150270025 A/G cg15654264 chr1:150340011 RPRD2 -0.45 -7.4 -0.38 1.09e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs11971779 0.618 rs3778931 chr7:139102490 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs34311866 0.808 rs62294491 chr4:969111 C/T cg14530993 chr4:882597 GAK 0.66 6.67 0.34 1.09e-10 Parkinson's disease; LUSC cis rs7830933 0.955 rs57220043 chr8:23602763 A/T cg04349084 chr8:23602677 NA 0.38 6.02 0.31 4.7e-9 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; LUSC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg04352962 chr1:209979756 IRF6 0.55 6.37 0.33 6.41e-10 Cleft lip with or without cleft palate; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg23758822 chr17:41437982 NA 1.04 19.64 0.73 1.23e-57 Menopause (age at onset); LUSC cis rs7786808 0.644 rs4909081 chr7:158200785 G/A cg09998033 chr7:158218633 PTPRN2 -0.53 -8.58 -0.42 3.63e-16 Obesity-related traits; LUSC cis rs7264396 0.563 rs6060569 chr20:34290731 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.64 -0.43 2.38e-16 Total cholesterol levels; LUSC cis rs807669 0.544 rs2040771 chr22:19161935 C/T cg02655711 chr22:19163373 SLC25A1 0.56 10.24 0.49 1.42e-21 Metabolite levels; LUSC cis rs6977660 0.714 rs10950753 chr7:19817302 G/A cg07541023 chr7:19748670 TWISTNB 0.61 6.57 0.34 1.91e-10 Thyroid stimulating hormone; LUSC cis rs6121246 0.520 rs6060425 chr20:30224355 C/T cg21427119 chr20:30132790 HM13 -0.41 -6.07 -0.32 3.47e-9 Mean corpuscular hemoglobin; LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg08470875 chr2:26401718 FAM59B -0.69 -9.34 -0.46 1.39e-18 Gut microbiome composition (summer); LUSC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg03146154 chr1:46216737 IPP -0.56 -8.13 -0.41 8.36e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1451375 0.729 rs6593017 chr7:50644812 G/A cg18232548 chr7:50535776 DDC 0.5 7.58 0.38 3.49e-13 Malaria; LUSC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11644478 chr21:40555479 PSMG1 0.88 15.87 0.66 1.19e-42 Cognitive function; LUSC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg19468946 chr17:37922297 IKZF3 -0.44 -6.92 -0.35 2.33e-11 Self-reported allergy; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg00166722 chr3:10149974 C3orf24 0.6 7.91 0.4 3.74e-14 Alzheimer's disease; LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 12.56 0.57 6.47e-30 Alzheimer's disease; LUSC cis rs9341808 0.622 rs684283 chr6:80967317 T/G cg08355045 chr6:80787529 NA -0.41 -6.87 -0.35 3.16e-11 Sitting height ratio; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg18758796 chr5:131593413 PDLIM4 -0.4 -6.53 -0.34 2.45e-10 Breast cancer; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.63 0.6 6.19e-34 Platelet count; LUSC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.19 0.32 1.74e-9 Neuroticism; LUSC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg12564285 chr5:131593104 PDLIM4 0.46 8.53 0.42 5.28e-16 Blood metabolite levels; LUSC cis rs1018697 1.000 rs7911528 chr10:104551567 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.43 0.33 4.37e-10 Colorectal adenoma (advanced); LUSC cis rs12620999 0.774 rs6711726 chr2:238101795 C/T cg23555395 chr2:238036564 NA -0.32 -5.69 -0.3 2.72e-8 Systemic lupus erythematosus; LUSC cis rs1335645 0.570 rs56200127 chr1:111628519 G/A cg00321911 chr1:111669324 DRAM2 -0.62 -6.49 -0.33 3.04e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg23630131 chr7:65973040 NA -0.21 -5.79 -0.3 1.66e-8 Aortic root size; LUSC cis rs6121246 0.647 rs6088855 chr20:30225792 C/T cg18721089 chr20:30220636 NA -0.38 -6.13 -0.32 2.54e-9 Mean corpuscular hemoglobin; LUSC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.87 15.06 0.64 1.8e-39 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.06 -0.31 3.71e-9 Total body bone mineral density; LUSC cis rs7903847 0.642 rs11189204 chr10:99164394 C/T cg08345082 chr10:99160200 RRP12 -0.35 -7.25 -0.37 2.93e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.45 0.86 2.28e-98 Chronic sinus infection; LUSC cis rs7605378 1.000 rs2577852 chr2:200687248 C/T cg17644776 chr2:200775616 C2orf69 0.36 5.68 0.3 2.89e-8 Osteoporosis; LUSC cis rs2304069 0.817 rs216132 chr5:149431259 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.63 -9.13 -0.45 6.82e-18 HIV-1 control; LUSC trans rs9467711 0.606 rs35076545 chr6:26603924 C/A cg06606381 chr12:133084897 FBRSL1 -0.81 -7.09 -0.36 8.24e-12 Autism spectrum disorder or schizophrenia; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg07727134 chr12:120222632 CIT -0.42 -6.55 -0.34 2.21e-10 N-glycan levels; LUSC cis rs3106136 0.933 rs35718240 chr4:95164030 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.1 -0.32 2.9e-9 Capecitabine sensitivity; LUSC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg12863693 chr15:85201151 NMB -0.26 -5.98 -0.31 5.71e-9 P wave terminal force; LUSC cis rs3136441 0.901 rs11039002 chr11:46857279 T/C cg01183595 chr11:46746236 F2 0.38 5.72 0.3 2.33e-8 HDL cholesterol; LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg03354898 chr7:1950403 MAD1L1 -0.33 -6.49 -0.33 3.03e-10 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.806 rs7204984 chr16:75475520 G/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.16 -0.36 5.2e-12 Dupuytren's disease; LUSC trans rs7829975 0.774 rs13259216 chr8:8673601 A/C cg21775007 chr8:11205619 TDH 0.44 6.28 0.32 1.06e-9 Mood instability; LUSC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg13393036 chr8:95962371 TP53INP1 -0.45 -9.35 -0.46 1.28e-18 Type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21871394 chr19:50380797 AKT1S1;TBC1D17 0.43 6.26 0.32 1.19e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7804356 1.000 rs3801820 chr7:26861353 A/G cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -8.96 -0.44 2.36e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8017423 0.935 rs4904661 chr14:90729332 T/C cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs9920506 0.536 rs12441998 chr15:78929372 G/A cg04896959 chr15:78267971 NA 0.38 6.84 0.35 3.75e-11 Post bronchodilator FEV1; LUSC cis rs2046867 0.818 rs1502754 chr3:72895345 G/T cg25664220 chr3:72788482 NA -0.6 -10.35 -0.49 5.89e-22 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9311676 0.609 rs11921259 chr3:58368646 A/G cg26110898 chr3:58419937 PDHB 0.44 7.18 0.37 4.67e-12 Systemic lupus erythematosus; LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.45 7.72 0.39 1.36e-13 Bipolar disorder; LUSC cis rs10911232 0.520 rs10797831 chr1:183036816 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.95 0.51 4.59e-24 Hypertriglyceridemia; LUSC cis rs12594515 1.000 rs6493167 chr15:45986809 G/A cg01629716 chr15:45996671 NA 0.4 6.12 0.32 2.57e-9 Waist circumference;Weight; LUSC cis rs11792861 0.566 rs67780641 chr9:111850710 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.08 0.36 8.49e-12 Menarche (age at onset); LUSC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg17294928 chr15:75287854 SCAMP5 -0.76 -10.12 -0.48 3.67e-21 Blood trace element (Zn levels); LUSC cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.08 -0.4 1.21e-14 Chronic sinus infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22470056 chr3:49947811 MON1A 0.39 5.96 0.31 6.45e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04039784 chr16:68877714 TMCO7 0.68 6.0 0.31 5.27e-9 Cognitive performance; LUSC cis rs2180341 0.814 rs6919277 chr6:127738050 T/C cg24812749 chr6:127587940 RNF146 0.73 10.31 0.49 8.33e-22 Breast cancer; LUSC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 7.23 0.37 3.41e-12 Rheumatoid arthritis; LUSC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg05585544 chr11:47624801 NA -0.42 -7.18 -0.37 4.55e-12 Subjective well-being; LUSC cis rs8114671 0.562 rs4911450 chr20:33512406 C/T cg08999081 chr20:33150536 PIGU 0.32 5.65 0.3 3.51e-8 Height; LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC cis rs2979489 0.891 rs16877096 chr8:30364388 T/C cg26383811 chr8:30366931 RBPMS -0.49 -7.66 -0.39 2.03e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs748404 0.646 rs2253268 chr15:43800968 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.41 5.95 0.31 6.94e-9 Lung cancer; LUSC cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg14458575 chr2:238380390 NA 0.68 11.98 0.55 9.46e-28 Prostate cancer; LUSC cis rs400736 0.602 rs4573544 chr1:8165247 C/T cg25007680 chr1:8021821 PARK7 -0.46 -6.82 -0.35 4.36e-11 Response to antidepressants and depression; LUSC cis rs17685 0.753 rs7804598 chr7:75702578 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.05 -0.4 1.5e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.61 9.09 0.45 8.83e-18 Total body bone mineral density; LUSC cis rs3771570 0.901 rs9052 chr2:242434809 G/T cg21155796 chr2:242212141 HDLBP 0.53 6.17 0.32 1.98e-9 Prostate cancer; LUSC cis rs11971779 0.616 rs6974907 chr7:139068729 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg16405210 chr4:1374714 KIAA1530 -0.53 -8.3 -0.41 2.7e-15 Obesity-related traits; LUSC cis rs6977660 1.000 rs10249989 chr7:19822296 A/G cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs7927592 0.913 rs12272917 chr11:68263370 T/C cg20283391 chr11:68216788 NA -0.61 -8.55 -0.42 4.43e-16 Total body bone mineral density; LUSC cis rs12620999 0.941 rs10929215 chr2:238037456 G/A cg23555395 chr2:238036564 NA -0.53 -8.91 -0.44 3.32e-17 Systemic lupus erythematosus; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg08677398 chr8:58056175 NA 0.58 6.95 0.36 1.96e-11 Developmental language disorder (linguistic errors); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg02605672 chr17:80854741 TBCD -0.41 -6.5 -0.34 3.01e-10 N-glycan levels; LUSC cis rs41271473 0.526 rs10916337 chr1:228714902 C/T cg16512390 chr1:228756714 NA 0.67 8.42 0.42 1.09e-15 Chronic lymphocytic leukemia; LUSC cis rs12136530 0.774 rs10442634 chr1:19775246 C/T cg01832549 chr1:19774989 CAPZB -0.32 -5.94 -0.31 7.33e-9 Lead levels in blood; LUSC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg15691649 chr6:25882328 NA -0.48 -6.53 -0.34 2.51e-10 Intelligence (multi-trait analysis); LUSC cis rs1729951 0.575 rs1654904 chr3:136681149 T/C cg21827317 chr3:136751795 NA 0.39 6.95 0.36 1.97e-11 Neuroticism; LUSC cis rs9443189 0.526 rs6902898 chr6:76201856 G/A cg01950844 chr6:76311363 SENP6 0.68 6.81 0.35 4.62e-11 Prostate cancer; LUSC cis rs12956009 0.583 rs9653016 chr18:44894189 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.14 0.32 2.36e-9 Educational attainment (years of education); LUSC cis rs2439831 0.867 rs689616 chr15:43761901 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs6933660 0.744 rs3800279 chr6:151766162 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.46 -5.65 -0.3 3.44e-8 Menarche (age at onset); LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg13047869 chr3:10149882 C3orf24 0.63 8.73 0.43 1.21e-16 Alzheimer's disease; LUSC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 7.71 0.39 1.41e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20068463 chr7:148725962 PDIA4 0.39 6.13 0.32 2.52e-9 Asthma; LUSC trans rs7824557 0.564 rs2736300 chr8:11235579 T/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.54 -0.34 2.27e-10 Retinal vascular caliber; LUSC cis rs4423214 1.000 rs4944062 chr11:71187294 G/T cg05163923 chr11:71159392 DHCR7 0.74 11.05 0.52 2.15e-24 Vitamin D levels; LUSC cis rs6696846 0.765 rs11576867 chr1:205064676 C/T cg21545522 chr1:205238299 TMCC2 0.46 8.69 0.43 1.7e-16 Red blood cell count; LUSC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg11301795 chr4:187892539 NA 0.87 16.76 0.68 3.62e-46 Lobe attachment (rater-scored or self-reported); LUSC trans rs2727020 0.553 rs4103567 chr11:49255389 C/T cg03929089 chr4:120376271 NA -0.63 -9.02 -0.44 1.49e-17 Coronary artery disease; LUSC cis rs11190604 0.767 rs11190519 chr10:102175133 C/T cg07080220 chr10:102295463 HIF1AN 0.59 7.61 0.38 2.86e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg13010199 chr12:38710504 ALG10B 0.7 11.66 0.54 1.34e-26 Heart rate; LUSC cis rs477692 0.673 rs579952 chr10:131356084 A/T cg05714579 chr10:131428358 MGMT -0.43 -6.19 -0.32 1.81e-9 Response to temozolomide; LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg26314531 chr2:26401878 FAM59B -0.7 -9.76 -0.47 5.69e-20 Gut microbiome composition (summer); LUSC cis rs714027 1.000 rs1003342 chr22:30570022 A/G cg11564601 chr22:30592435 NA 0.37 6.86 0.35 3.33e-11 Lymphocyte counts; LUSC cis rs72781680 0.752 rs55859418 chr2:23904231 C/A cg08917208 chr2:24149416 ATAD2B 0.98 9.69 0.47 9.64e-20 Lymphocyte counts; LUSC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg09904177 chr6:26538194 HMGN4 -0.48 -7.42 -0.38 9.66e-13 Schizophrenia; LUSC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg10792982 chr14:105748885 BRF1 0.51 9.42 0.46 7.53e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs7568458 0.811 rs3755014 chr2:85764006 C/T cg23752985 chr2:85803571 VAMP8 0.32 6.59 0.34 1.71e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2013441 0.866 rs2526492 chr17:20095615 C/A cg04132472 chr17:19861366 AKAP10 -0.35 -5.69 -0.3 2.83e-8 Obesity-related traits; LUSC cis rs16986825 0.570 rs5752822 chr22:29266025 A/G cg02153584 chr22:29168773 CCDC117 0.54 6.3 0.33 9.2e-10 Pancreatic cancer; LUSC cis rs12286929 0.699 rs1048932 chr11:115044850 C/A cg04055981 chr11:115044050 NA -0.38 -6.59 -0.34 1.67e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6906287 0.647 rs12660455 chr6:118717382 C/T cg21191810 chr6:118973309 C6orf204 0.34 6.12 0.32 2.69e-9 Electrocardiographic conduction measures; LUSC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg11632617 chr15:75315747 PPCDC -0.52 -6.8 -0.35 4.83e-11 Blood trace element (Zn levels); LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg11965913 chr1:205819406 PM20D1 0.92 18.96 0.72 6.41e-55 Menarche (age at onset); LUSC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg27266027 chr21:40555129 PSMG1 -0.39 -5.68 -0.3 2.97e-8 Cognitive function; LUSC cis rs8013055 0.846 rs8013827 chr14:105970176 C/T cg19700328 chr14:106028568 NA 0.37 6.37 0.33 6.43e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg17178900 chr1:205818956 PM20D1 0.44 6.23 0.32 1.44e-9 Prostate-specific antigen levels; LUSC cis rs7584330 0.704 rs72620821 chr2:238362615 C/A cg16989719 chr2:238392110 NA -0.45 -7.32 -0.37 1.9e-12 Prostate cancer; LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg11062466 chr8:58055876 NA 0.68 9.07 0.44 1.05e-17 Developmental language disorder (linguistic errors); LUSC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg06134567 chr22:46658398 PKDREJ -0.46 -5.65 -0.3 3.37e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg05472934 chr7:22766657 IL6 0.51 8.28 0.41 2.92e-15 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17105206 chr16:67211972 KIAA0895L -0.49 -6.14 -0.32 2.38e-9 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg11645453 chr3:52864694 ITIH4 0.38 8.65 0.43 2.25e-16 Bipolar disorder; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg04267008 chr7:1944627 MAD1L1 -0.54 -8.14 -0.41 7.98e-15 Bipolar disorder and schizophrenia; LUSC cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg26647111 chr11:31128758 NA -0.42 -6.0 -0.31 5.03e-9 Red blood cell count; LUSC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg15557168 chr22:42548783 NA -0.37 -6.24 -0.32 1.31e-9 Cognitive function; LUSC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg00271210 chr6:167070053 RPS6KA2 -0.28 -5.7 -0.3 2.64e-8 Crohn's disease; LUSC cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.33 0.41 2.13e-15 High light scatter reticulocyte count; LUSC cis rs2635047 1.000 rs2684825 chr18:44666415 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.92 0.35 2.34e-11 Educational attainment; LUSC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg05535760 chr7:792225 HEATR2 0.78 9.17 0.45 5.01e-18 Cerebrospinal P-tau181p levels; LUSC trans rs10432489 0.572 rs4346342 chr2:181706206 G/A cg01101058 chr14:70235157 SFRS5;LOC100289511 0.54 6.02 0.31 4.55e-9 QT interval; LUSC cis rs73198271 0.545 rs78352360 chr8:8627831 G/A cg01851573 chr8:8652454 MFHAS1 0.63 7.36 0.37 1.45e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg04944784 chr2:26401820 FAM59B -0.74 -10.43 -0.5 3.01e-22 Gut microbiome composition (summer); LUSC cis rs8072100 0.846 rs4264433 chr17:45737275 A/T cg25173405 chr17:45401733 C17orf57 0.4 6.42 0.33 4.81e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7923609 0.902 rs7897379 chr10:65301725 T/C cg01631684 chr10:65280961 REEP3 -0.41 -6.37 -0.33 6.16e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.42 0.69 8.19e-49 Chronic sinus infection; LUSC cis rs9372253 0.967 rs9400379 chr6:110713783 A/G cg00083206 chr6:110721305 DDO -0.47 -8.55 -0.42 4.63e-16 Platelet distribution width; LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg27535305 chr1:53392650 SCP2 0.36 6.78 0.35 5.43e-11 Monocyte count; LUSC trans rs9650657 0.530 rs6982381 chr8:10952500 A/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.8 -0.39 8.25e-14 Neuroticism; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg01125463 chr6:42946178 PEX6 -0.38 -6.23 -0.32 1.44e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg00166722 chr3:10149974 C3orf24 0.58 7.81 0.39 7.42e-14 Alzheimer's disease; LUSC cis rs10186029 0.509 rs10203749 chr2:213935855 T/A cg08319019 chr2:214017104 IKZF2 -0.41 -6.03 -0.31 4.3e-9 Systemic sclerosis; LUSC cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -8.65 -0.43 2.25e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs965469 0.779 rs6139048 chr20:3239753 T/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.68 -0.3 2.88e-8 IFN-related cytopenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16919317 chr8:120868184 DSCC1 -0.39 -6.19 -0.32 1.74e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.546 rs10018080 chr4:98758436 C/A cg17366294 chr4:99064904 C4orf37 0.56 8.86 0.44 4.88e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg21251018 chr6:28226885 NKAPL 0.33 6.21 0.32 1.55e-9 Cardiac Troponin-T levels; LUSC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg26695010 chr11:65641043 EFEMP2 -0.46 -7.03 -0.36 1.17e-11 Eosinophil percentage of white cells; LUSC cis rs5771069 0.931 rs5771222 chr22:50445704 C/T cg27068297 chr22:50451975 IL17REL -0.29 -5.97 -0.31 6.05e-9 Ulcerative colitis; LUSC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg01017244 chr2:74357527 NA 0.67 11.88 0.55 2.12e-27 Gestational age at birth (maternal effect); LUSC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg07636037 chr3:49044803 WDR6 0.68 9.18 0.45 4.58e-18 Menarche (age at onset); LUSC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg00343986 chr7:65444356 GUSB -0.42 -6.38 -0.33 6.07e-10 Aortic root size; LUSC cis rs2797160 1.000 rs1739354 chr6:126017808 G/C cg05901451 chr6:126070800 HEY2 0.57 8.61 0.43 2.85e-16 Endometrial cancer; LUSC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg04369109 chr6:150039330 LATS1 -0.59 -8.65 -0.43 2.27e-16 Lung cancer; LUSC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg09509183 chr1:209979624 IRF6 -0.45 -6.75 -0.35 6.63e-11 Monobrow; LUSC cis rs775227 0.574 rs13067967 chr3:113265215 C/G cg18753928 chr3:113234510 CCDC52 -0.46 -6.43 -0.33 4.38e-10 Dental caries; LUSC cis rs6120849 0.663 rs13041792 chr20:33545055 G/A cg24642439 chr20:33292090 TP53INP2 0.62 7.11 0.36 6.9e-12 Protein C levels; LUSC cis rs662064 0.962 rs648399 chr1:10556485 T/C cg20482658 chr1:10539492 PEX14 -0.31 -6.57 -0.34 1.96e-10 Asthma; LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.61e-29 Prudent dietary pattern; LUSC cis rs61931739 0.517 rs12816252 chr12:34067693 G/A cg06521331 chr12:34319734 NA -0.48 -7.69 -0.39 1.65e-13 Morning vs. evening chronotype; LUSC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg12564285 chr5:131593104 PDLIM4 -0.35 -6.58 -0.34 1.83e-10 Blood metabolite levels; LUSC cis rs1801251 1.000 rs6746294 chr2:233583050 C/G cg25237894 chr2:233734115 C2orf82 -0.32 -5.91 -0.31 8.41e-9 Coronary artery disease; LUSC cis rs11608355 0.515 rs2287184 chr12:109970251 T/C cg05360138 chr12:110035743 NA 0.92 12.2 0.56 1.48e-28 Neuroticism; LUSC trans rs72674100 1.000 rs28504129 chr4:97990879 G/A cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs16976116 0.855 rs28522816 chr15:55495114 C/G cg11288833 chr15:55489084 RSL24D1 0.49 5.8 0.3 1.53e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7149337 0.809 rs10134478 chr14:51693708 G/C cg23942311 chr14:51606299 NA 0.48 10.51 0.5 1.59e-22 Cancer; LUSC cis rs7107174 0.901 rs2450138 chr11:77924870 C/T cg02023728 chr11:77925099 USP35 0.53 7.55 0.38 4.11e-13 Testicular germ cell tumor; LUSC cis rs1865760 0.602 rs2157050 chr6:26020431 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 7.03 0.36 1.19e-11 Height; LUSC cis rs7707921 1.000 rs749402 chr5:81561325 C/T cg15871215 chr5:81402204 ATG10 -0.43 -6.25 -0.32 1.29e-9 Breast cancer; LUSC cis rs3862030 0.694 rs12781742 chr10:104227469 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.92 -0.44 3.02e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6598955 0.543 rs60433268 chr1:26548055 A/C cg12744634 chr1:26560303 CCDC21 0.39 5.88 0.31 1.01e-8 Obesity-related traits; LUSC cis rs11190604 0.943 rs7900678 chr10:102229016 T/C cg07080220 chr10:102295463 HIF1AN 0.64 8.53 0.42 5.05e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg03264133 chr6:25882463 NA -0.4 -7.02 -0.36 1.25e-11 Height; LUSC cis rs868036 0.718 rs8030456 chr15:68076856 C/T cg27219399 chr15:67835830 MAP2K5 0.34 5.66 0.3 3.33e-8 Restless legs syndrome; LUSC cis rs4588572 0.643 rs1159929 chr5:77768820 A/G cg11547950 chr5:77652471 NA 0.48 6.88 0.35 2.92e-11 Triglycerides; LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg10360139 chr7:1886902 MAD1L1 -0.44 -6.77 -0.35 5.8e-11 Bipolar disorder and schizophrenia; LUSC cis rs17092148 0.945 rs6058115 chr20:33358397 T/G cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs4654899 0.865 rs3856173 chr1:21114833 C/T cg01072550 chr1:21505969 NA -0.47 -7.0 -0.36 1.43e-11 Superior frontal gyrus grey matter volume; LUSC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.11 0.36 7.29e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs483069 0.933 rs487638 chr1:34422278 C/T cg03916189 chr9:132360049 NA 0.39 6.48 0.33 3.26e-10 Depressive symptoms (SSRI exposure interaction); LUSC cis rs72781680 1.000 rs72781632 chr2:24198342 A/C cg20701182 chr2:24300061 SF3B14 0.76 7.73 0.39 1.26e-13 Lymphocyte counts; LUSC cis rs7590368 0.673 rs17365181 chr2:10937980 T/C cg15705551 chr2:10952987 PDIA6 0.52 5.78 0.3 1.7e-8 Educational attainment (years of education); LUSC cis rs2288327 0.643 rs1559908 chr2:179336347 C/T cg11548914 chr2:179343871 FKBP7;PLEKHA3;MIR548N -0.55 -6.87 -0.35 3.07e-11 Atrial fibrillation; LUSC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg00310523 chr12:86230176 RASSF9 0.44 8.2 0.41 5.3e-15 Major depressive disorder; LUSC cis rs1559088 0.947 rs7256182 chr19:33558591 G/A cg03563238 chr19:33554763 RHPN2 -0.4 -6.23 -0.32 1.43e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg24399712 chr22:39784796 NA 0.63 11.93 0.55 1.49e-27 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9457247 0.624 rs17524252 chr6:167466978 T/G cg25258033 chr6:167368657 RNASET2 0.44 6.69 0.34 9.54e-11 Crohn's disease; LUSC cis rs921968 0.541 rs620596 chr2:219462419 G/A cg02176678 chr2:219576539 TTLL4 0.75 14.7 0.63 4.6e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs6987853 0.830 rs12542919 chr8:42356035 C/T cg09913449 chr8:42400586 C8orf40 -0.41 -6.76 -0.35 6.35e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs9807989 0.524 rs4851576 chr2:103028895 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.14e-12 Asthma; LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg12412775 chr1:25698385 RHCE -0.29 -5.86 -0.31 1.1e-8 Erythrocyte sedimentation rate; LUSC cis rs2901656 0.546 rs9425598 chr1:172371922 A/G cg03748243 chr1:172413542 C1orf105;PIGC 0.36 7.11 0.36 7.21e-12 Red cell distribution width;Platelet distribution width; LUSC cis rs9399135 0.967 rs6902954 chr6:135313994 C/A cg24558204 chr6:135376177 HBS1L 0.6 9.41 0.46 8.48e-19 Red blood cell count; LUSC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg06808227 chr14:105710500 BRF1 -0.64 -9.33 -0.45 1.48e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs6840360 0.615 rs66852535 chr4:152472227 C/A cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs9467711 0.606 rs34273322 chr6:26415409 T/A cg12826209 chr6:26865740 GUSBL1 0.64 5.69 0.3 2.74e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs9467711 0.606 rs9379900 chr6:26603811 A/C cg06606381 chr12:133084897 FBRSL1 -0.68 -6.74 -0.35 7.03e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg06505273 chr16:24850292 NA 0.4 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg00933542 chr6:150070202 PCMT1 0.34 7.02 0.36 1.25e-11 Lung cancer; LUSC cis rs7789940 0.817 rs6946310 chr7:75936099 T/C cg15798862 chr7:76129360 DTX2 -0.43 -6.91 -0.35 2.39e-11 Multiple sclerosis; LUSC cis rs3770081 1.000 rs76297018 chr2:86227007 G/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.0 -6.48 -0.33 3.38e-10 Facial emotion recognition (sad faces); LUSC trans rs417096 0.893 rs302602 chr6:39732663 T/C cg17457912 chr17:1617102 C17orf91 -0.33 -6.4 -0.33 5.3e-10 Hypospadias; LUSC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.9 0.61 5.49e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9549260 0.755 rs2721071 chr13:41144507 G/A cg21288729 chr13:41239152 FOXO1 0.57 8.75 0.43 1.05e-16 Red blood cell count; LUSC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg00750074 chr16:89608354 SPG7 -0.46 -8.05 -0.4 1.46e-14 Multiple myeloma (IgH translocation); LUSC cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg15423357 chr2:25149977 NA 0.43 8.54 0.42 4.92e-16 Body mass index; LUSC cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg06784218 chr1:46089804 CCDC17 0.35 6.04 0.31 4.14e-9 Platelet count; LUSC cis rs11650494 0.908 rs57390430 chr17:47374886 G/A cg08112188 chr17:47440006 ZNF652 1.18 10.16 0.49 2.53e-21 Prostate cancer; LUSC trans rs459571 0.959 rs460888 chr9:136913123 C/G cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.43 -6.13 -0.32 2.48e-9 Platelet distribution width; LUSC cis rs8078723 0.738 rs3816472 chr17:38142677 A/C cg17467752 chr17:38218738 THRA -0.7 -11.29 -0.53 2.96e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7267979 1.000 rs6115153 chr20:25325567 T/C cg03522245 chr20:25566470 NINL -0.35 -5.71 -0.3 2.45e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.92 -0.35 2.28e-11 Menopause (age at onset); LUSC cis rs6667605 0.527 rs6673993 chr1:2552071 T/C cg18932078 chr1:2524107 MMEL1 0.28 6.07 0.32 3.54e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg25019777 chr4:53525403 USP46 0.39 6.25 0.32 1.27e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg04315214 chr1:2043799 PRKCZ 0.46 9.51 0.46 3.79e-19 Height; LUSC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg18681998 chr4:17616180 MED28 -0.86 -16.14 -0.66 1.03e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg20476274 chr7:133979776 SLC35B4 0.84 15.6 0.65 1.33e-41 Mean platelet volume; LUSC cis rs888194 0.686 rs11067376 chr12:110027795 A/G cg05360138 chr12:110035743 NA 0.38 5.77 0.3 1.84e-8 Neuroticism; LUSC cis rs12422267 0.536 rs11831679 chr12:132609960 C/T cg26561844 chr12:132562101 EP400 -0.54 -5.71 -0.3 2.54e-8 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs2832077 0.943 rs11700746 chr21:30189207 T/C cg08807101 chr21:30365312 RNF160 -0.53 -6.68 -0.34 9.85e-11 Cognitive test performance; LUSC cis rs11031096 0.727 rs12290828 chr11:4144867 C/G cg18678763 chr11:4115507 RRM1 -0.49 -7.25 -0.37 2.98e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg11494091 chr17:61959527 GH2 -0.63 -13.3 -0.59 1.08e-32 Prudent dietary pattern; LUSC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.94 0.31 7.29e-9 Personality dimensions; LUSC cis rs8038465 0.592 rs1542580 chr15:73935834 C/G cg15420318 chr15:73925796 NPTN 0.58 10.11 0.48 3.77e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10875746 0.903 rs10875738 chr12:48473739 T/A cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC trans rs4713118 0.699 rs200969 chr6:27859453 T/C cg05267876 chr1:229644265 NUP133 -0.49 -6.2 -0.32 1.67e-9 Parkinson's disease; LUSC cis rs1670533 1.000 rs62294756 chr4:1097676 G/A cg02018176 chr4:1364513 KIAA1530 -0.46 -6.4 -0.33 5.39e-10 Recombination rate (females); LUSC trans rs6076960 0.629 rs6054024 chr20:6229282 A/C cg17788362 chr6:86352627 SYNCRIP 0.42 6.13 0.32 2.51e-9 Smooth-surface caries; LUSC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg19717773 chr7:2847554 GNA12 -0.36 -6.18 -0.32 1.9e-9 Height; LUSC cis rs12210905 0.688 rs10456051 chr6:27463436 T/C cg08851530 chr6:28072375 NA 0.93 5.71 0.3 2.47e-8 Hip circumference adjusted for BMI; LUSC cis rs9921338 0.961 rs4356497 chr16:11414196 C/G cg00044050 chr16:11439710 C16orf75 0.49 6.58 0.34 1.77e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs8060686 0.516 rs2290699 chr16:68289059 C/T cg05110241 chr16:68378359 PRMT7 -0.53 -6.54 -0.34 2.25e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2153535 0.967 rs10484750 chr6:8378609 A/G cg07606381 chr6:8435919 SLC35B3 -0.51 -7.83 -0.39 6.41e-14 Motion sickness; LUSC cis rs72634258 0.842 rs7545745 chr1:8165667 T/A cg00042356 chr1:8021962 PARK7 -0.54 -6.8 -0.35 4.87e-11 Inflammatory bowel disease; LUSC cis rs13089785 1.000 rs13089785 chr3:123653909 A/C cg02558132 chr3:123411198 MYLK 0.35 6.11 0.32 2.78e-9 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.824 rs7172309 chr15:72384483 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.59 -0.38 3.22e-13 Red blood cell count; LUSC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg04511125 chr2:88470314 THNSL2 -0.43 -6.49 -0.33 3.15e-10 Response to metformin (IC50); LUSC cis rs6089584 0.893 rs2281735 chr20:60582540 T/A cg24733560 chr20:60626293 TAF4 0.35 5.75 0.3 1.98e-8 Body mass index; LUSC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg03161606 chr19:29218774 NA 0.62 8.83 0.44 6.02e-17 Methadone dose in opioid dependence; LUSC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg18904891 chr8:8559673 CLDN23 0.59 8.07 0.4 1.25e-14 Obesity-related traits; LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg18402987 chr7:1209562 NA 0.69 7.41 0.38 1.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg07148914 chr20:33460835 GGT7 0.55 8.42 0.42 1.16e-15 Height; LUSC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg23758822 chr17:41437982 NA 1.0 19.2 0.72 7.15e-56 Menopause (age at onset); LUSC cis rs1949733 1.000 rs6837429 chr4:8502374 A/G cg13073564 chr4:8508604 NA -0.49 -9.23 -0.45 3.23e-18 Response to antineoplastic agents; LUSC cis rs11637445 0.677 rs10152422 chr15:68102929 C/T cg08079166 chr15:68083412 MAP2K5 -0.38 -7.81 -0.39 7.45e-14 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg09640425 chr7:158790006 NA 0.4 6.46 0.33 3.8e-10 Facial morphology (factor 20); LUSC cis rs36093844 0.800 rs112468922 chr11:85576694 A/G cg25872744 chr11:85566296 CCDC83 -0.46 -6.15 -0.32 2.26e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.48 -6.4 -0.33 5.17e-10 Tonsillectomy; LUSC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs12545109 0.613 rs10958480 chr8:57278717 A/T cg09654669 chr8:57350985 NA -0.44 -5.93 -0.31 7.46e-9 Obesity-related traits; LUSC cis rs4865169 0.783 rs7668814 chr4:57825190 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.44 6.68 0.34 1.02e-10 Breast cancer; LUSC trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21659725 chr3:3221576 CRBN 0.62 10.41 0.49 3.63e-22 Intelligence (multi-trait analysis); LUSC cis rs250677 0.687 rs2915809 chr5:148452111 A/T cg23229984 chr5:148520753 ABLIM3 0.41 6.45 0.33 3.99e-10 Breast cancer; LUSC cis rs7746199 0.736 rs34064842 chr6:27688625 G/T cg26958806 chr6:27640298 NA 0.74 6.04 0.31 4.02e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4290604 0.748 rs7594554 chr2:238065981 A/G cg23555395 chr2:238036564 NA -0.47 -6.34 -0.33 7.5e-10 Asthma; LUSC cis rs868036 0.645 rs28539889 chr15:68121428 T/A cg24579218 chr15:68104479 NA -0.39 -6.31 -0.33 9.08e-10 Restless legs syndrome; LUSC trans rs2739330 0.731 rs5751792 chr22:24401542 G/A cg06437703 chr8:37914619 EIF4EBP1 -0.66 -11.59 -0.54 2.39e-26 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.77e-9 Aortic root size; LUSC cis rs11945232 1.000 rs6854710 chr4:88334640 A/G cg23841344 chr4:88312519 HSD17B11 -0.69 -10.72 -0.51 3.14e-23 Intelligence (multi-trait analysis); LUSC cis rs7954584 0.635 rs3847694 chr12:122325820 A/G cg21171335 chr12:122356390 WDR66 0.58 8.84 0.44 5.4e-17 Mean corpuscular volume; LUSC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg03806693 chr22:41940476 POLR3H 0.92 13.27 0.59 1.42e-32 Crohn's disease;Inflammatory bowel disease; LUSC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg06544989 chr22:39130855 UNC84B 0.32 5.72 0.3 2.39e-8 Menopause (age at onset); LUSC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3771570 0.901 rs3821285 chr2:242421314 A/G cg21155796 chr2:242212141 HDLBP -0.49 -5.96 -0.31 6.46e-9 Prostate cancer; LUSC trans rs61931739 0.517 rs7313663 chr12:34417058 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.47 0.59 2.57e-33 Morning vs. evening chronotype; LUSC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg12639453 chr1:2035780 PRKCZ -0.34 -7.17 -0.37 4.97e-12 Height; LUSC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.67 8.12 0.41 9.05e-15 Lung function (FEV1/FVC); LUSC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg02534363 chr3:47050950 NBEAL2 0.38 6.16 0.32 2.09e-9 Colorectal cancer; LUSC cis rs11971779 0.648 rs6967836 chr7:139079944 C/G cg23387468 chr7:139079360 LUC7L2 0.41 6.19 0.32 1.73e-9 Diisocyanate-induced asthma; LUSC trans rs7937682 0.602 rs4936804 chr11:111743851 A/C cg18187862 chr3:45730750 SACM1L -0.51 -6.17 -0.32 1.99e-9 Primary sclerosing cholangitis; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg17366294 chr4:99064904 C4orf37 0.57 9.91 0.48 1.88e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1003719 0.591 rs2835618 chr21:38503126 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -9.54 -0.46 3.07e-19 Eye color traits; LUSC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg18230493 chr5:56204884 C5orf35 -0.55 -8.84 -0.44 5.44e-17 Breast cancer;Breast cancer (early onset); LUSC trans rs877282 0.898 rs12357995 chr10:765739 T/C cg22713356 chr15:30763199 NA 1.07 14.17 0.61 5.24e-36 Uric acid levels; LUSC cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.36e-12 Motion sickness; LUSC cis rs2652834 0.851 rs4775625 chr15:63410577 G/A cg05507819 chr15:63340323 TPM1 0.45 5.68 0.3 2.9e-8 HDL cholesterol; LUSC cis rs317865 0.737 rs28483204 chr4:16205098 A/G cg04764131 chr4:16228633 TAPT1;FLJ39653 0.61 5.79 0.3 1.6e-8 Kidney disease (early stage) in type 1 diabetes; LUSC cis rs6700896 0.897 rs1938494 chr1:66117691 G/T cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg27284194 chr4:1044797 NA 0.36 5.91 0.31 8.46e-9 Longevity; LUSC cis rs11864453 0.826 rs9941087 chr16:72118324 G/A cg01557791 chr16:72042693 DHODH -0.56 -8.1 -0.41 1.03e-14 Fibrinogen levels; LUSC cis rs2235649 0.798 rs78540053 chr16:1853275 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.01 -0.31 4.92e-9 Blood metabolite levels; LUSC cis rs748404 0.697 rs530188 chr15:43545314 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.42 6.04 0.31 4.03e-9 Lung cancer; LUSC cis rs9902453 0.845 rs116840018 chr17:28232049 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.39 0.46 9.94e-19 Coffee consumption (cups per day); LUSC cis rs12195417 0.603 rs9350981 chr6:84200221 C/T cg08257003 chr6:84140564 ME1 0.3 7.01 0.36 1.33e-11 Schizophrenia; LUSC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.65 0.34 1.19e-10 Lung cancer; LUSC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.79 0.43 7.99e-17 Schizophrenia; LUSC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg21951975 chr1:209979733 IRF6 0.56 6.8 0.35 4.91e-11 Coronary artery disease; LUSC cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.6 -0.5 7.74e-23 Monocyte percentage of white cells; LUSC cis rs7523050 0.643 rs35438081 chr1:109402831 G/T cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC trans rs10506458 0.688 rs60936040 chr12:63416461 G/A cg22491629 chr6:157744540 C6orf35 -0.62 -7.86 -0.4 5.48e-14 Hemostatic factors and hematological phenotypes; LUSC cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg15839431 chr19:19639596 YJEFN3 -0.59 -6.32 -0.33 8.21e-10 Bipolar disorder; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg04234412 chr22:24373322 LOC391322 -0.86 -13.97 -0.61 3.02e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7296418 0.630 rs11608305 chr12:123791165 C/G cg00376283 chr12:123451042 ABCB9 0.69 10.67 0.5 4.56e-23 Platelet count; LUSC cis rs952623 0.649 rs17171519 chr7:39060312 T/C cg15212455 chr7:39170539 POU6F2 0.37 6.03 0.31 4.45e-9 Intelligence (multi-trait analysis); LUSC trans rs9388451 0.805 rs1028481 chr6:126106573 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.34 -0.46 1.38e-18 Brugada syndrome; LUSC cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs7929679 0.521 rs10768097 chr11:34792902 T/C cg06937548 chr11:34938143 PDHX;APIP 0.4 5.91 0.31 8.29e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04228274 chr13:21751145 MRP63;SKA3 -0.51 -6.07 -0.32 3.57e-9 Bipolar disorder and schizophrenia; LUSC trans rs6600671 1.000 rs11249350 chr1:121178446 C/T cg00646200 chr1:148855367 NA 0.45 7.09 0.36 8.01e-12 Hip geometry; LUSC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.06e-34 Prostate cancer; LUSC cis rs2463822 0.925 rs1528730 chr11:62081181 A/C cg06239285 chr11:62104954 ASRGL1 0.95 10.47 0.5 2.18e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.71 0.3 2.47e-8 Tonsillectomy; LUSC cis rs12900413 0.687 rs28653538 chr15:90304964 T/C cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.4e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg11645453 chr3:52864694 ITIH4 0.32 7.34 0.37 1.6e-12 Electroencephalogram traits; LUSC cis rs10426930 0.700 rs7253212 chr19:5021391 G/A cg25246084 chr19:4971487 KDM4B -0.34 -6.2 -0.32 1.65e-9 Monocyte percentage of white cells; LUSC cis rs9549367 0.737 rs9549712 chr13:113902355 G/A cg18105134 chr13:113819100 PROZ -0.68 -9.6 -0.47 1.9e-19 Platelet distribution width; LUSC trans rs8026898 0.961 rs7170107 chr15:70010647 C/T cg27385734 chr18:15003734 NA 0.31 6.15 0.32 2.17e-9 Rheumatoid arthritis; LUSC cis rs1453414 1 rs1453414 chr11:5829084 G/C cg13902645 chr11:5959945 NA -0.54 -6.03 -0.31 4.37e-9 Oral cavity and pharyngeal cancer;Oropharynx cancer; LUSC cis rs950027 0.620 rs2467862 chr15:45643843 T/G cg04036182 chr15:45458818 NA 0.35 5.74 0.3 2.13e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs208520 0.909 rs9345809 chr6:67017543 T/C cg07460842 chr6:66804631 NA 0.89 9.06 0.44 1.1e-17 Exhaled nitric oxide output; LUSC cis rs500891 0.574 rs10455419 chr6:84154242 T/G cg08257003 chr6:84140564 ME1 0.37 9.09 0.45 8.78e-18 Platelet-derived growth factor BB levels; LUSC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg09034736 chr1:150693464 HORMAD1 0.44 6.16 0.32 2.05e-9 Melanoma; LUSC cis rs9314323 0.964 rs3808576 chr8:26266834 G/A cg13160058 chr8:26243215 BNIP3L -0.41 -7.46 -0.38 7.53e-13 Red cell distribution width; LUSC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg24110177 chr3:50126178 RBM5 -0.55 -8.85 -0.44 5.15e-17 Intelligence (multi-trait analysis); LUSC cis rs6489882 0.867 rs2384072 chr12:113367422 T/C cg20102336 chr12:113376681 OAS3 -0.4 -5.74 -0.3 2.17e-8 Chronic lymphocytic leukemia; LUSC cis rs7481584 0.624 rs375579 chr11:3065300 G/C cg08508325 chr11:3079039 CARS 0.39 8.73 0.43 1.2e-16 Calcium levels; LUSC trans rs7824557 0.564 rs6601584 chr8:11232343 C/G cg08975724 chr8:8085496 FLJ10661 -0.45 -6.69 -0.34 9.56e-11 Retinal vascular caliber; LUSC cis rs12464559 0.522 rs4316939 chr2:152525120 C/T cg01189475 chr2:152685088 ARL5A -0.59 -6.37 -0.33 6.31e-10 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg12935359 chr14:103987150 CKB -0.51 -7.82 -0.39 6.85e-14 Body mass index; LUSC cis rs7572644 0.766 rs1350481 chr2:28185808 G/C cg27432699 chr2:27873401 GPN1 -0.52 -6.46 -0.33 3.72e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.18 -0.32 1.82e-9 Total body bone mineral density; LUSC trans rs11098499 0.821 rs3775852 chr4:120454556 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs72781680 1.000 rs6731001 chr2:24192952 A/G cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs2282300 0.739 rs2225909 chr11:30329744 T/C cg25418670 chr11:30344373 C11orf46 0.64 9.23 0.45 3.29e-18 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg05340658 chr4:99064831 C4orf37 0.65 10.9 0.51 7.24e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs2573652 1.000 rs2573651 chr15:100514109 T/G cg09918751 chr15:100517450 ADAMTS17 -0.42 -7.74 -0.39 1.19e-13 Height; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg00149659 chr3:10157352 C3orf10 1.0 13.2 0.59 2.59e-32 Alzheimer's disease; LUSC cis rs6076065 0.548 rs6048740 chr20:23325047 G/A cg11657817 chr20:23433608 CST11 0.49 9.74 0.47 6.78e-20 Facial morphology (factor 15, philtrum width); LUSC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg11247378 chr22:39784982 NA -0.62 -11.22 -0.52 5.2e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg01770232 chr7:22766155 IL6 0.4 5.66 0.3 3.24e-8 Lung cancer; LUSC cis rs35146811 0.735 rs1636975 chr7:99812089 A/G cg22906224 chr7:99728672 NA -0.47 -6.52 -0.34 2.56e-10 Coronary artery disease; LUSC cis rs2404602 0.692 rs35138393 chr15:76977617 G/A cg23625390 chr15:77176239 SCAPER 0.48 7.24 0.37 3.12e-12 Blood metabolite levels; LUSC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg02423579 chr7:2872169 GNA12 -0.47 -6.73 -0.35 7.52e-11 Height; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg06873352 chr17:61820015 STRADA 0.7 12.62 0.57 3.9e-30 Prudent dietary pattern; LUSC cis rs28595532 0.748 rs115651241 chr4:119363509 C/T cg02775129 chr4:119771670 NA -0.79 -6.58 -0.34 1.81e-10 Cannabis dependence symptom count; LUSC cis rs4845459 0.933 rs6700181 chr1:152593087 A/G cg08895932 chr1:152778580 LCE1C -0.38 -6.53 -0.34 2.46e-10 Psoriasis; LUSC trans rs7395662 0.591 rs11039766 chr11:48488715 T/C cg21153622 chr11:89784906 NA -0.39 -5.98 -0.31 5.58e-9 HDL cholesterol; LUSC cis rs12368653 0.840 rs3816896 chr12:58195773 C/T cg00677455 chr12:58241039 CTDSP2 -0.38 -5.75 -0.3 2.07e-8 Multiple sclerosis; LUSC cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01809437 chr16:84695622 KLHL36 0.45 6.07 0.32 3.44e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6598955 0.671 rs17163868 chr1:26648381 A/G cg00852783 chr1:26633632 UBXN11 0.48 5.87 0.31 1.06e-8 Obesity-related traits; LUSC trans rs3749237 0.964 rs1799843 chr3:49849723 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.47 6.6 0.34 1.57e-10 Resting heart rate; LUSC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg21963583 chr11:68658836 MRPL21 0.54 8.26 0.41 3.37e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg08736216 chr1:53307985 ZYG11A 0.3 6.19 0.32 1.73e-9 Monocyte count; LUSC trans rs12310956 0.510 rs11612987 chr12:33879130 T/C cg26384229 chr12:38710491 ALG10B 0.56 8.69 0.43 1.66e-16 Morning vs. evening chronotype; LUSC cis rs9359856 0.564 rs913425 chr6:90256934 T/C cg13799429 chr6:90582589 CASP8AP2 -0.47 -5.76 -0.3 1.93e-8 Bipolar disorder; LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg05064044 chr6:292385 DUSP22 -0.5 -7.1 -0.36 7.77e-12 Menopause (age at onset); LUSC cis rs11785400 0.753 rs9694286 chr8:143737157 G/T cg24634471 chr8:143751801 JRK 0.5 7.18 0.37 4.56e-12 Schizophrenia; LUSC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12756686 chr19:29218302 NA 0.67 9.61 0.47 1.85e-19 Methadone dose in opioid dependence; LUSC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg05025164 chr4:1340916 KIAA1530 0.51 8.3 0.41 2.61e-15 Obesity-related traits; LUSC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg17366294 chr4:99064904 C4orf37 0.59 10.56 0.5 1.13e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg01879757 chr17:41196368 BRCA1 -0.46 -7.1 -0.36 7.49e-12 Menopause (age at onset); LUSC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg21972741 chr5:435613 AHRR 0.36 6.84 0.35 3.82e-11 Cystic fibrosis severity; LUSC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg18904891 chr8:8559673 CLDN23 0.6 8.13 0.41 8.6e-15 Obesity-related traits; LUSC cis rs11190604 1.000 rs7088827 chr10:102303865 C/G cg16342193 chr10:102329863 NA -0.35 -6.22 -0.32 1.53e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10751667 0.643 rs7396046 chr11:937176 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.42 0.33 4.63e-10 Alzheimer's disease (late onset); LUSC cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg03146154 chr1:46216737 IPP 0.5 7.46 0.38 7.53e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1371867 0.810 rs1618528 chr8:101259134 T/C cg00191853 chr8:101177733 SPAG1 0.35 5.73 0.3 2.23e-8 Atrioventricular conduction; LUSC cis rs9341808 0.718 rs9361584 chr6:80819946 G/C cg08355045 chr6:80787529 NA 0.56 9.6 0.46 2.04e-19 Sitting height ratio; LUSC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg06505273 chr16:24850292 NA 0.39 5.76 0.3 1.91e-8 Intelligence (multi-trait analysis); LUSC cis rs1062746 0.711 rs8056833 chr16:87378388 G/C cg02258303 chr16:87377426 FBXO31 -0.57 -9.29 -0.45 2.07e-18 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs2348418 0.864 rs7304776 chr12:28713567 C/A cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.48e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs6942756 0.876 rs822040 chr7:129065922 C/G cg02491457 chr7:128862824 NA 0.39 5.76 0.3 1.91e-8 White matter hyperintensity burden; LUSC cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg06552810 chr11:31128660 NA -0.42 -7.35 -0.37 1.5e-12 Red blood cell count; LUSC cis rs6688613 0.694 rs3820387 chr1:166820284 A/T cg07049167 chr1:166818506 POGK 0.54 8.16 0.41 6.71e-15 Refractive astigmatism; LUSC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg04450456 chr4:17643702 FAM184B 0.38 6.55 0.34 2.12e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12220238 1.000 rs7096553 chr10:75957835 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.14 0.36 5.87e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7786808 0.505 rs67537656 chr7:158192646 C/T cg01191920 chr7:158217561 PTPRN2 0.46 9.14 0.45 6.05e-18 Obesity-related traits; LUSC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg20243544 chr17:37824526 PNMT 0.5 7.06 0.36 9.93e-12 Asthma; LUSC cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg04455712 chr21:45112962 RRP1B 0.43 8.08 0.4 1.17e-14 Mean corpuscular volume; LUSC cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg04362960 chr10:104952993 NT5C2 0.57 8.26 0.41 3.53e-15 Arsenic metabolism; LUSC cis rs9399135 0.967 rs6919862 chr6:135352443 C/A cg22676075 chr6:135203613 NA 0.47 7.35 0.37 1.52e-12 Red blood cell count; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg12564285 chr5:131593104 PDLIM4 0.47 8.25 0.41 3.63e-15 Breast cancer; LUSC cis rs10751667 0.714 rs7933889 chr11:972270 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.19e-10 Alzheimer's disease (late onset); LUSC trans rs2262909 0.925 rs73019838 chr19:22247732 T/A cg05197062 chr11:11642011 GALNTL4 0.57 7.89 0.4 4.43e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9398803 0.865 rs9375442 chr6:126803137 A/C cg19875578 chr6:126661172 C6orf173 0.41 5.93 0.31 7.66e-9 Male-pattern baldness; LUSC cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg24450063 chr1:156163899 SLC25A44 1.18 30.08 0.85 4.31e-97 Testicular germ cell tumor; LUSC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg20891558 chr2:74357851 NA 0.79 14.23 0.61 2.92e-36 Gestational age at birth (maternal effect); LUSC cis rs6469656 1.000 rs4422805 chr8:117651299 C/T cg24004040 chr8:117650383 NA -0.43 -6.22 -0.32 1.46e-9 Colorectal cancer; LUSC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg04944784 chr2:26401820 FAM59B -0.69 -9.86 -0.47 2.64e-20 Gut microbiome composition (summer); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07564088 chr5:95170684 NA 0.72 5.96 0.31 6.45e-9 Cognitive performance; LUSC cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg11102782 chr19:18549136 ISYNA1 -0.35 -6.59 -0.34 1.72e-10 Breast cancer; LUSC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg24578937 chr1:2090814 PRKCZ 0.43 9.42 0.46 7.54e-19 Height; LUSC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg11062466 chr8:58055876 NA 0.46 6.51 0.34 2.76e-10 Developmental language disorder (linguistic errors); LUSC cis rs7589342 0.792 rs13426321 chr2:106500280 G/A cg16077055 chr2:106428750 NCK2 0.34 6.29 0.33 1.02e-9 Addiction; LUSC trans rs1005277 0.579 rs2474608 chr10:38457109 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.35 -0.46 1.34e-18 Extrinsic epigenetic age acceleration; LUSC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg09650180 chr20:62225654 GMEB2 -0.68 -9.73 -0.47 7.21e-20 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg16606324 chr3:10149918 C3orf24 0.64 9.55 0.46 2.89e-19 Alzheimer's disease; LUSC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg13683864 chr3:40499215 RPL14 -1.11 -21.85 -0.77 2.39e-66 Renal cell carcinoma; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg05552183 chr6:42928497 GNMT 0.48 8.13 0.41 8.59e-15 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs4805272 0.539 rs11883172 chr19:29318536 C/T cg00950971 chr10:72015325 NPFFR1 -0.37 -5.96 -0.31 6.51e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9325144 0.647 rs1386018 chr12:39104360 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.7 -0.47 9.52e-20 Morning vs. evening chronotype; LUSC cis rs2070488 0.775 rs6780349 chr3:38555178 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.67 -11.89 -0.55 2.05e-27 Electrocardiographic conduction measures; LUSC cis rs4682868 0.581 rs13068366 chr3:42922020 G/A cg21365077 chr3:42922735 NA 0.42 5.91 0.31 8.52e-9 Monocyte percentage of white cells; LUSC cis rs9303401 0.659 rs7224276 chr17:56897827 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.34 0.59 7.79e-33 Cognitive test performance; LUSC trans rs17685 0.753 rs4398845 chr7:75716781 G/A cg19862616 chr7:65841803 NCRNA00174 1.12 19.09 0.72 1.96e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs113835537 0.529 rs2277302 chr11:66240882 T/C cg24851651 chr11:66362959 CCS 0.56 8.68 0.43 1.76e-16 Airway imaging phenotypes; LUSC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -8.15 -0.41 7.15e-15 Hemoglobin concentration; LUSC cis rs2658782 0.654 rs2248531 chr11:93255363 G/T cg15737290 chr11:93063684 CCDC67 0.59 7.67 0.39 1.89e-13 Pulmonary function decline; LUSC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.24 -0.41 3.96e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7208859 0.623 rs73269916 chr17:29096326 A/G cg13385521 chr17:29058706 SUZ12P 0.7 7.05 0.36 1.05e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs8141529 0.778 rs763073 chr22:29215542 G/A cg02153584 chr22:29168773 CCDC117 0.65 10.25 0.49 1.24e-21 Lymphocyte counts; LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg15147215 chr3:52552868 STAB1 -0.33 -6.62 -0.34 1.45e-10 Bipolar disorder; LUSC cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg25382214 chr1:3105252 PRDM16 -0.3 -5.85 -0.3 1.18e-8 Migraine; LUSC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg17211192 chr8:82754475 SNX16 0.58 8.21 0.41 4.83e-15 Diastolic blood pressure; LUSC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg12639453 chr1:2035780 PRKCZ 0.29 6.05 0.31 3.9e-9 Height; LUSC cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.63 0.85 1.69e-95 Chronic sinus infection; LUSC cis rs7100689 0.646 rs12253992 chr10:82158710 G/A cg00277334 chr10:82204260 NA -0.49 -7.15 -0.36 5.4e-12 Post bronchodilator FEV1; LUSC cis rs9929218 0.551 rs3785134 chr16:68728938 C/T cg01251360 chr16:68772225 CDH1 -0.26 -6.2 -0.32 1.62e-9 Colorectal cancer; LUSC trans rs2727020 0.595 rs7924311 chr11:49507573 G/A cg15704280 chr7:45808275 SEPT13 -1.1 -22.22 -0.77 8.57e-68 Coronary artery disease; LUSC trans rs2739330 0.760 rs1002286 chr22:24257337 A/G cg06437703 chr8:37914619 EIF4EBP1 0.63 10.48 0.5 2.11e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg23158103 chr7:148848205 ZNF398 -0.49 -8.02 -0.4 1.74e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs61931739 0.534 rs10844801 chr12:34230940 A/T cg13010199 chr12:38710504 ALG10B 0.54 8.5 0.42 6.35e-16 Morning vs. evening chronotype; LUSC trans rs911555 0.755 rs8016676 chr14:103904842 C/A cg17675199 chr6:35436792 RPL10A -0.41 -6.01 -0.31 4.89e-9 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.95 -0.58 2.27e-31 Platelet count; LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg21724239 chr8:58056113 NA 0.8 8.44 0.42 9.52e-16 Developmental language disorder (linguistic errors); LUSC cis rs7577851 0.625 rs67560216 chr2:69584616 C/A cg10773587 chr2:69614142 GFPT1 0.57 6.24 0.32 1.29e-9 Parkinson's disease (age of onset); LUSC cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg22601191 chr20:60968625 CABLES2 0.56 9.67 0.47 1.11e-19 Colorectal cancer; LUSC cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg13319975 chr6:146136371 FBXO30 -0.47 -7.1 -0.36 7.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg22903657 chr4:1355424 KIAA1530 -0.48 -8.05 -0.4 1.42e-14 Obesity-related traits; LUSC cis rs2637266 0.967 rs12244619 chr10:78352502 C/T cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs2204008 0.687 rs11181339 chr12:38322271 G/T cg13010199 chr12:38710504 ALG10B 0.59 9.1 0.45 8.57e-18 Bladder cancer; LUSC trans rs4295623 0.585 rs34421088 chr8:11589042 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -7.97 -0.4 2.56e-14 Morning vs. evening chronotype; LUSC cis rs7216064 0.589 rs8072723 chr17:66056970 T/A cg12091567 chr17:66097778 LOC651250 0.92 14.26 0.62 2.34e-36 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg01884057 chr2:25150051 NA 0.46 10.95 0.51 4.75e-24 Body mass index; LUSC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.34 -0.33 7.63e-10 Lung cancer; LUSC cis rs13223928 0.565 rs10240820 chr7:3154415 T/C cg19214707 chr7:3157722 NA -0.49 -9.38 -0.46 1.05e-18 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.47 0.42 7.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12406019 0.510 rs2025614 chr1:78618151 G/A cg20826526 chr3:156266748 SSR3 -0.44 -6.61 -0.34 1.52e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg22535103 chr8:58192502 C8orf71 -0.79 -8.4 -0.42 1.28e-15 Developmental language disorder (linguistic errors); LUSC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg19418458 chr7:158789849 NA -0.52 -8.31 -0.41 2.39e-15 Facial morphology (factor 20); LUSC cis rs6845621 0.782 rs1377149 chr4:18917722 A/G cg12196642 chr4:18937545 NA -0.34 -6.46 -0.33 3.75e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7914558 1.000 rs7067970 chr10:104913870 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.63 0.47 1.5700000000000001e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg21466736 chr12:48725269 NA -0.32 -5.71 -0.3 2.56e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs983392 0.836 rs12453 chr11:59945745 T/C cg20284999 chr11:59952153 MS4A6A -0.38 -6.36 -0.33 6.59e-10 Alzheimer's disease (late onset); LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg10150615 chr22:24372951 LOC391322 -0.43 -7.18 -0.37 4.58e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1997103 0.911 rs6945663 chr7:55407011 C/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg23711669 chr6:146136114 FBXO30 0.88 16.07 0.66 1.92e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg00509249 chr6:109615579 CCDC162 -0.34 -6.12 -0.32 2.55e-9 Reticulocyte fraction of red cells; LUSC cis rs2841277 0.646 rs2819419 chr14:105406238 A/C cg15352829 chr14:105391018 PLD4 -0.42 -8.71 -0.43 1.42e-16 Rheumatoid arthritis; LUSC cis rs7945718 0.967 rs10741602 chr11:12761699 A/T cg25843174 chr11:12811716 TEAD1 0.32 7.07 0.36 9.39e-12 Educational attainment (years of education); LUSC cis rs7110373 1 rs7110373 chr11:122813224 C/T cg27398637 chr11:122830231 C11orf63 -0.39 -6.44 -0.33 4.05e-10 Age at voice drop; LUSC trans rs2392780 0.536 rs400818 chr8:128336546 T/C cg10897648 chr18:56338258 MALT1 -0.42 -6.38 -0.33 5.94e-10 Breast cancer (early onset); LUSC cis rs9815354 0.767 rs73071337 chr3:41822518 G/C cg03022575 chr3:42003672 ULK4 0.85 8.65 0.43 2.27e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg09455208 chr3:40491958 NA 0.54 9.48 0.46 4.72e-19 Renal cell carcinoma; LUSC cis rs7264396 0.573 rs55969606 chr20:34075688 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.32 -0.33 8.54e-10 Total cholesterol levels; LUSC cis rs1728785 1.000 rs1645935 chr16:68563791 A/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs9341808 0.754 rs9361591 chr6:80953255 C/A cg08355045 chr6:80787529 NA 0.56 9.66 0.47 1.22e-19 Sitting height ratio; LUSC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg23985595 chr17:80112537 CCDC57 0.3 5.79 0.3 1.66e-8 Life satisfaction; LUSC cis rs2985684 0.948 rs12897941 chr14:50016701 G/C cg04989706 chr14:50066350 PPIL5 -0.45 -6.03 -0.31 4.36e-9 Carotid intima media thickness; LUSC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg06238570 chr21:40685208 BRWD1 0.46 7.05 0.36 1.04e-11 Cognitive function; LUSC cis rs2742417 0.603 rs2742453 chr3:45765858 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.21 -0.37 3.71e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg26597838 chr10:835615 NA 1.19 16.22 0.66 5.02e-44 Eosinophil percentage of granulocytes; LUSC trans rs6502050 0.835 rs8075086 chr17:80092649 A/G cg07393940 chr7:158741817 NA 0.38 6.88 0.35 2.93e-11 Life satisfaction; LUSC cis rs1865760 0.963 rs9356991 chr6:25901758 C/A cg16482183 chr6:26056742 HIST1H1C 0.43 6.45 0.33 3.96e-10 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22429776 chr1:113162371 ST7L;CAPZA1 -0.39 -6.28 -0.32 1.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg26395211 chr5:140044315 WDR55 -0.38 -5.84 -0.3 1.27e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg07362569 chr17:61921086 SMARCD2 0.37 7.64 0.39 2.27e-13 Prudent dietary pattern; LUSC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg13206674 chr6:150067644 NUP43 0.63 10.24 0.49 1.38e-21 Lung cancer; LUSC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg01097406 chr16:89675127 NA -0.35 -7.04 -0.36 1.09e-11 Vitiligo; LUSC cis rs12801636 0.512 rs11227247 chr11:65422853 A/C cg24147428 chr11:65409760 SIPA1 -0.51 -6.03 -0.31 4.3e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs1865760 0.508 rs9379820 chr6:26049924 T/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.9 0.4 4.01e-14 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17189058 chr2:70418126 C2orf42 -0.42 -6.06 -0.31 3.68e-9 Electrocardiographic conduction measures; LUSC cis rs1044826 0.642 rs295473 chr3:139215585 T/C cg15131784 chr3:139108705 COPB2 0.39 6.36 0.33 6.82e-10 Obesity-related traits; LUSC cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg08470875 chr2:26401718 FAM59B -0.65 -8.68 -0.43 1.74e-16 Gut microbiome composition (summer); LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.42 -0.33 4.76e-10 Bipolar disorder and schizophrenia; LUSC cis rs7098414 0.511 rs7898787 chr10:82156042 G/A cg00277334 chr10:82204260 NA -0.6 -9.94 -0.48 1.5e-20 Post bronchodilator FEV1; LUSC cis rs870825 0.616 rs7682505 chr4:185640648 C/T cg04058563 chr4:185651563 MLF1IP 0.86 13.38 0.59 5.34e-33 Blood protein levels; LUSC cis rs3092073 0.624 rs11696623 chr20:44580380 C/T cg27529037 chr20:44575021 PCIF1 0.41 7.12 0.36 6.68e-12 Intelligence (multi-trait analysis); LUSC cis rs1167827 0.680 rs1167800 chr7:75176196 G/A cg16384552 chr7:74938386 SPDYE8P -0.49 -7.07 -0.36 8.87e-12 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs644799 0.622 rs1255167 chr11:95500213 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.66 9.51 0.46 3.83e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg01097406 chr16:89675127 NA 0.33 6.84 0.35 3.71e-11 Vitiligo; LUSC trans rs941408 0.515 rs759067 chr19:2775668 C/T cg22153745 chr1:153894579 GATAD2B -0.51 -6.94 -0.36 2.09e-11 Total cholesterol levels; LUSC cis rs2652834 1.000 rs34575783 chr15:63397686 G/C cg05507819 chr15:63340323 TPM1 0.69 8.32 0.41 2.22e-15 HDL cholesterol; LUSC cis rs240764 0.817 rs239206 chr6:101137332 T/G cg09795085 chr6:101329169 ASCC3 0.42 6.17 0.32 2.01e-9 Neuroticism; LUSC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg21918786 chr6:109611834 NA 0.4 7.08 0.36 8.81e-12 Reticulocyte fraction of red cells; LUSC cis rs1568889 0.887 rs7102237 chr11:28344296 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.72 12.63 0.57 3.6e-30 Bipolar disorder; LUSC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg11752832 chr7:134001865 SLC35B4 0.54 7.92 0.4 3.61e-14 Mean platelet volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00840257 chr16:8963031 CARHSP1 -0.49 -6.37 -0.33 6.24e-10 Bipolar disorder and schizophrenia; LUSC cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.28 -0.45 2.14e-18 Schizophrenia; LUSC cis rs4947962 0.648 rs76692262 chr7:55089831 A/G cg23757825 chr7:55092271 EGFR -0.66 -8.4 -0.42 1.25e-15 Subjective response to lithium treatment; LUSC cis rs939658 0.776 rs35382567 chr15:79440897 C/T cg17916960 chr15:79447300 NA -0.53 -10.55 -0.5 1.24e-22 Refractive error; LUSC cis rs16895831 0.519 rs16895856 chr6:42564921 A/C cg10605015 chr6:42532144 UBR2 -0.49 -5.98 -0.31 5.69e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC trans rs12310956 0.532 rs7979535 chr12:33947450 A/C cg13010199 chr12:38710504 ALG10B -0.53 -8.18 -0.41 6.13e-15 Morning vs. evening chronotype; LUSC cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg18964960 chr10:1102726 WDR37 -0.43 -5.84 -0.3 1.27e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs7582720 1.000 rs72926787 chr2:203818299 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9902453 0.780 rs3115093 chr17:28039755 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.55 0.53 3.4e-26 Coffee consumption (cups per day); LUSC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg17507749 chr15:85114479 UBE2QP1 0.68 8.57 0.42 3.92e-16 Schizophrenia; LUSC trans rs61931739 0.517 rs2636074 chr12:34064056 C/T cg13010199 chr12:38710504 ALG10B 0.54 8.3 0.41 2.53e-15 Morning vs. evening chronotype; LUSC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg08392591 chr16:89556376 ANKRD11 0.39 5.75 0.3 1.97e-8 Multiple myeloma (IgH translocation); LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg12379764 chr21:47803548 PCNT -0.47 -6.79 -0.35 5.12e-11 Testicular germ cell tumor; LUSC cis rs7267979 0.966 rs6037097 chr20:25347221 C/T cg03522245 chr20:25566470 NINL 0.35 5.69 0.3 2.82e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg13736514 chr6:26305472 NA -0.49 -9.53 -0.46 3.35e-19 Educational attainment; LUSC cis rs73416724 1.000 rs17209407 chr6:43358362 A/G cg26312998 chr6:43337775 ZNF318 0.57 6.72 0.34 8.1e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9325144 0.534 rs4882283 chr12:38710249 C/T cg26384229 chr12:38710491 ALG10B 0.64 10.28 0.49 1.03e-21 Morning vs. evening chronotype; LUSC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg09034736 chr1:150693464 HORMAD1 0.4 5.72 0.3 2.34e-8 Melanoma; LUSC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg13047869 chr3:10149882 C3orf24 -0.42 -6.66 -0.34 1.11e-10 Alzheimer's disease; LUSC cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg22529645 chr1:3704559 LRRC47 0.35 6.54 0.34 2.25e-10 Red cell distribution width; LUSC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg10523679 chr1:76189770 ACADM 0.87 13.7 0.6 3.27e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11158026 0.546 rs8011446 chr14:55425913 C/G cg04306507 chr14:55594613 LGALS3 0.35 6.15 0.32 2.17e-9 Parkinson's disease; LUSC cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg18681998 chr4:17616180 MED28 -0.88 -15.29 -0.64 2.29e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs11743006 0.626 rs56352214 chr5:136506500 G/A cg07379741 chr17:7311030 NLGN2 0.41 6.11 0.32 2.82e-9 Mathematical ability; LUSC cis rs6942756 1.000 rs2103232 chr7:128951232 G/T cg02491457 chr7:128862824 NA -0.48 -6.57 -0.34 1.92e-10 White matter hyperintensity burden; LUSC cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg21535247 chr6:8435926 SLC35B3 0.59 9.03 0.44 1.37e-17 Motion sickness; LUSC cis rs62400317 0.762 rs12209944 chr6:44788156 G/C cg18551225 chr6:44695536 NA -0.47 -7.21 -0.37 3.74e-12 Total body bone mineral density; LUSC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg21724239 chr8:58056113 NA 0.85 9.53 0.46 3.26e-19 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.77e-30 Motion sickness; LUSC cis rs7917772 0.582 rs4917978 chr10:104366353 C/T cg05855489 chr10:104503620 C10orf26 0.47 7.2 0.37 4.12e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs897984 0.609 rs4889609 chr16:31026427 A/G cg02466173 chr16:30829666 NA -0.53 -10.22 -0.49 1.58e-21 Dementia with Lewy bodies; LUSC cis rs208515 0.556 rs10455193 chr6:66691456 G/A cg07460842 chr6:66804631 NA 1.06 14.42 0.62 5.65e-37 Exhaled nitric oxide levels; LUSC cis rs9815354 0.812 rs73071315 chr3:41805887 T/C cg03022575 chr3:42003672 ULK4 0.83 8.52 0.42 5.39e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs13315871 0.929 rs13082278 chr3:58318224 A/G cg20936604 chr3:58311152 NA -0.72 -6.92 -0.35 2.36e-11 Cholesterol, total; LUSC cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg26116260 chr4:7069785 GRPEL1 1.1 15.44 0.65 5.63e-41 Monocyte percentage of white cells; LUSC cis rs400736 0.729 rs9434948 chr1:8004963 A/C cg25007680 chr1:8021821 PARK7 -0.49 -7.21 -0.37 3.83e-12 Response to antidepressants and depression; LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.57 -8.56 -0.42 4.16e-16 Gut microbiome composition (summer); LUSC cis rs1358748 0.522 rs1885276 chr1:67568824 G/T cg02640540 chr1:67518911 SLC35D1 0.58 5.97 0.31 6.09e-9 Tuberculosis; LUSC cis rs10276303 0.519 rs6462035 chr7:3397101 G/A cg21248987 chr7:3385318 SDK1 -0.39 -6.6 -0.34 1.66e-10 Dupuytren's disease; LUSC cis rs8017423 0.765 rs8017170 chr14:90721849 T/A cg14092571 chr14:90743983 NA -0.35 -5.83 -0.3 1.29e-8 Mortality in heart failure; LUSC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg15485101 chr11:133734466 NA 0.4 7.23 0.37 3.23e-12 Childhood ear infection; LUSC cis rs4654899 0.758 rs6668370 chr1:21369568 C/T cg01072550 chr1:21505969 NA -0.53 -8.14 -0.41 8.09e-15 Superior frontal gyrus grey matter volume; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.57 0.38 3.58e-13 Prudent dietary pattern; LUSC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg10556349 chr10:835070 NA 0.56 6.19 0.32 1.72e-9 Eosinophil percentage of granulocytes; LUSC trans rs236907 0.859 rs17650310 chr1:171757204 A/G cg13482142 chr2:234261155 NA 0.48 5.95 0.31 6.7e-9 Mean platelet volume; LUSC cis rs4974559 0.790 rs11933855 chr4:1315183 C/T cg02980000 chr4:1222292 CTBP1 0.77 8.91 0.44 3.38e-17 Systolic blood pressure; LUSC cis rs7592578 0.679 rs59929070 chr2:191327852 A/G cg11845111 chr2:191398756 TMEM194B -0.84 -10.9 -0.51 6.99e-24 Diastolic blood pressure; LUSC cis rs17767294 0.541 rs72845051 chr6:27610545 G/A cg08851530 chr6:28072375 NA 0.9 6.3 0.33 9.55e-10 Parkinson's disease; LUSC cis rs1507153 0.847 rs9361422 chr6:79377738 C/G cg05283184 chr6:79620031 NA -0.42 -7.09 -0.36 7.92e-12 Sjögren's syndrome; LUSC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg22800045 chr5:56110881 MAP3K1 0.71 7.59 0.38 3.32e-13 Type 2 diabetes; LUSC cis rs7215564 0.818 rs4889878 chr17:78662479 G/T cg09596252 chr17:78655493 RPTOR 0.54 5.86 0.31 1.13e-8 Myopia (pathological); LUSC trans rs877282 0.797 rs7079164 chr10:756363 A/G cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.12 -0.36 6.8e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg08470875 chr2:26401718 FAM59B 0.68 9.16 0.45 5.31e-18 Gut microbiome composition (summer); LUSC trans rs10506458 0.915 rs12423078 chr12:63397529 C/T cg22491629 chr6:157744540 C6orf35 -0.92 -10.95 -0.51 4.68e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs1348850 0.574 rs12988366 chr2:178417945 A/C cg23306229 chr2:178417860 TTC30B -0.55 -5.74 -0.3 2.1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg21770322 chr7:97807741 LMTK2 0.4 7.03 0.36 1.19e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06748231 chr5:1112251 SLC12A7 -0.51 -6.23 -0.32 1.42e-9 Bipolar disorder and schizophrenia; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg02675527 chr2:114030824 PAX8;LOC440839 -0.58 -9.16 -0.45 5.28e-18 Lymphocyte counts; LUSC cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg13256891 chr4:100009986 ADH5 -0.43 -5.95 -0.31 6.64e-9 Alcohol dependence; LUSC cis rs11168351 0.864 rs12228750 chr12:48496997 G/A cg24011408 chr12:48396354 COL2A1 -0.39 -5.67 -0.3 3.01e-8 Bipolar disorder and schizophrenia; LUSC cis rs7560272 0.513 rs7558546 chr2:73937732 A/T cg20560298 chr2:73613845 ALMS1 0.42 6.31 0.33 9.04e-10 Schizophrenia; LUSC cis rs11030122 0.604 rs10835557 chr11:4083121 A/G cg08557956 chr11:4115526 RRM1 -0.45 -5.94 -0.31 7.02e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12756686 chr19:29218302 NA 0.68 9.59 0.46 2.11e-19 Methadone dose in opioid dependence; LUSC cis rs2688608 0.967 rs2688609 chr10:75658181 A/G cg17411546 chr10:75410026 SYNPO2L 0.43 6.43 0.33 4.44e-10 Inflammatory bowel disease; LUSC cis rs3770081 1.000 rs1561328 chr2:86272758 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.8 -5.95 -0.31 6.7e-9 Facial emotion recognition (sad faces); LUSC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg04287289 chr16:89883240 FANCA 0.76 6.26 0.32 1.19e-9 Skin colour saturation; LUSC cis rs189798 0.738 rs330908 chr8:8995166 A/G cg15556689 chr8:8085844 FLJ10661 0.46 6.53 0.34 2.47e-10 Myopia (pathological); LUSC cis rs6964587 1.000 rs2282975 chr7:91761638 A/G cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.15e-8 Breast cancer; LUSC cis rs8060686 0.641 rs12599880 chr16:68152035 A/G cg04539111 chr16:67997858 SLC12A4 -0.45 -6.03 -0.31 4.27e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs953492 0.644 rs12145759 chr1:243411405 G/C cg25284624 chr1:224180302 NA -0.43 -6.54 -0.34 2.3e-10 Diastolic blood pressure; LUSC cis rs7824557 0.628 rs2572387 chr8:11204165 C/T cg27411982 chr8:10470053 RP1L1 0.38 5.75 0.3 1.96e-8 Retinal vascular caliber; LUSC cis rs1775715 0.769 rs2808102 chr10:32117749 A/T cg04359828 chr10:32216031 ARHGAP12 0.41 6.95 0.36 1.95e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4888262 0.508 rs4888258 chr16:74634198 G/T cg01733217 chr16:74700730 RFWD3 0.8 13.44 0.59 3.38e-33 Testicular germ cell tumor; LUSC cis rs7786808 0.579 rs4045391 chr7:158181826 T/C cg09998033 chr7:158218633 PTPRN2 -0.51 -8.23 -0.41 4.13e-15 Obesity-related traits; LUSC cis rs4253772 0.872 rs45528736 chr22:46638312 A/G cg09491104 chr22:46646882 C22orf40 -0.59 -6.48 -0.33 3.23e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg22920501 chr2:26401640 FAM59B -0.8 -11.67 -0.54 1.27e-26 Gut microbiome composition (summer); LUSC cis rs1577917 0.958 rs12198971 chr6:86525445 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg16060761 chr17:80687452 NA -0.42 -6.79 -0.35 5.12e-11 Breast cancer; LUSC cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg21535247 chr6:8435926 SLC35B3 0.6 9.22 0.45 3.32e-18 Motion sickness; LUSC cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg11584989 chr19:19387371 SF4 0.56 6.81 0.35 4.64e-11 Bipolar disorder; LUSC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg11752832 chr7:134001865 SLC35B4 0.59 9.29 0.45 2.08e-18 Mean platelet volume; LUSC trans rs2235573 0.527 rs139887 chr22:38371396 G/C cg19894588 chr14:64061835 NA 0.49 7.07 0.36 9.02e-12 Glioblastoma;Glioma; LUSC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg16524733 chr11:117070046 TAGLN 0.43 7.62 0.38 2.64e-13 Blood protein levels; LUSC cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg23711669 chr6:146136114 FBXO30 0.92 17.7 0.7 6.44e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs137603 0.644 rs137619 chr22:39706360 A/C cg17798944 chr22:39715225 SNORD43;RPL3 -0.54 -8.51 -0.42 5.83e-16 Primary biliary cholangitis; LUSC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.54 7.5 0.38 5.84e-13 Multiple sclerosis; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg09068169 chr17:952071 ABR 0.48 6.31 0.33 9.06e-10 Neuroticism; LUSC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC trans rs61931739 0.534 rs1352207 chr12:34036862 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.5 -0.38 5.8e-13 Morning vs. evening chronotype; LUSC cis rs908922 0.651 rs6671924 chr1:152485830 T/C cg20991723 chr1:152506922 NA 0.51 9.51 0.46 3.98e-19 Hair morphology; LUSC cis rs6964587 0.869 rs2374519 chr7:91541481 T/C cg17063962 chr7:91808500 NA -0.53 -8.18 -0.41 6.04e-15 Breast cancer; LUSC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.06 -0.4 1.36e-14 Lung cancer; LUSC cis rs1023500 0.505 rs134878 chr22:42663874 A/G cg05082376 chr22:42548792 NA -0.41 -6.38 -0.33 5.84e-10 Schizophrenia; LUSC cis rs8062405 0.965 rs7359397 chr16:28885659 C/T cg09754948 chr16:28834200 ATXN2L 0.41 5.86 0.31 1.13e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7000551 0.725 rs2443496 chr8:22365788 G/A cg12081754 chr8:22256438 SLC39A14 0.42 6.38 0.33 5.76e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg21770322 chr7:97807741 LMTK2 0.51 9.1 0.45 8.4e-18 Breast cancer; LUSC cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg13256891 chr4:100009986 ADH5 -0.44 -5.89 -0.31 9.49e-9 Alcohol dependence; LUSC cis rs34779708 0.702 rs7087150 chr10:35542138 A/T cg03585969 chr10:35415529 CREM 0.55 7.59 0.38 3.21e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9926296 0.609 rs4785714 chr16:89798404 G/T cg04287289 chr16:89883240 FANCA -0.5 -7.6 -0.38 3.07e-13 Vitiligo; LUSC cis rs9811920 0.809 rs4577503 chr3:99657922 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.69 -0.34 9.52e-11 Axial length; LUSC cis rs992157 0.735 rs13393821 chr2:219076742 C/G cg20019365 chr2:219134978 PNKD;AAMP 0.49 7.69 0.39 1.71e-13 Colorectal cancer; LUSC cis rs2742417 1.000 rs2742386 chr3:45756310 A/C cg18779283 chr3:45636154 LIMD1 -0.34 -5.9 -0.31 8.79e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs8179 0.645 rs17766836 chr7:92258961 C/T cg15732164 chr7:92237376 CDK6 -0.43 -5.91 -0.31 8.45e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg06618935 chr21:46677482 NA -0.4 -7.66 -0.39 2.02e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7759001 0.857 rs3734575 chr6:27371011 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC trans rs3942852 0.568 rs10769312 chr11:48094769 C/T cg15704280 chr7:45808275 SEPT13 0.61 7.98 0.4 2.4e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs11048434 0.736 rs12823100 chr12:9108908 C/A cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18301423 chr5:131593218 PDLIM4 0.46 7.01 0.36 1.34e-11 Acylcarnitine levels; LUSC cis rs10193935 1.000 rs12618105 chr2:42414146 T/G cg27598129 chr2:42591480 NA -0.61 -8.05 -0.4 1.48e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg03929089 chr4:120376271 NA 0.9 13.63 0.6 6.33e-34 Height; LUSC trans rs9650657 0.645 rs4841408 chr8:10516336 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.71 -0.39 1.44e-13 Neuroticism; LUSC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg25554036 chr4:6271136 WFS1 0.62 12.65 0.57 3.08e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4466137 0.868 rs4703962 chr5:82999808 A/G cg16102102 chr5:83017553 HAPLN1 -0.93 -14.22 -0.61 3.28e-36 Prostate cancer; LUSC cis rs7647973 0.771 rs9865051 chr3:49166069 C/T cg07636037 chr3:49044803 WDR6 0.9 10.52 0.5 1.55e-22 Menarche (age at onset); LUSC cis rs4356932 1.000 rs7699624 chr4:76962631 G/T cg00809888 chr4:76862425 NAAA 0.36 6.14 0.32 2.38e-9 Blood protein levels; LUSC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.47 0.38 6.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg26314531 chr2:26401878 FAM59B 0.66 8.48 0.42 7.57e-16 Gut microbiome composition (summer); LUSC cis rs10986311 0.802 rs1323761 chr9:127116942 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.46 7.37 0.37 1.33e-12 Vitiligo; LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.52 8.33 0.41 2.08e-15 Bipolar disorder; LUSC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.78 -0.3 1.73e-8 Alzheimer's disease (late onset); LUSC cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg23029597 chr12:123009494 RSRC2 -0.73 -9.88 -0.48 2.32e-20 Body mass index; LUSC trans rs9944715 0.954 rs4890317 chr18:43770510 A/G cg01718231 chr17:29326311 RNF135 -0.52 -7.59 -0.38 3.19e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs35883536 0.647 rs2783696 chr1:101044089 G/A cg09408571 chr1:101003634 GPR88 0.29 5.7 0.3 2.62e-8 Monocyte count; LUSC cis rs9914988 0.943 rs4795465 chr17:27151498 A/G cg19789473 chr17:27170043 C17orf63 0.3 5.8 0.3 1.51e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg00603274 chr11:61596626 FADS2 -0.58 -8.05 -0.4 1.49e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs950776 0.518 rs11632604 chr15:78821914 T/C cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg20821713 chr7:1055600 C7orf50 -0.55 -7.07 -0.36 9.18e-12 Bronchopulmonary dysplasia; LUSC cis rs2285947 1.000 rs2285946 chr7:21583329 T/C cg04471919 chr7:21584483 DNAH11 0.35 7.75 0.39 1.1e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg05707623 chr12:122985044 ZCCHC8 -0.56 -7.75 -0.39 1.09e-13 Body mass index; LUSC cis rs68170813 0.559 rs17429146 chr7:106964281 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.85 -0.47 3e-20 Coronary artery disease; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg13047869 chr3:10149882 C3orf24 0.6 8.27 0.41 3.15e-15 Alzheimer's disease; LUSC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg03709012 chr19:19516395 GATAD2A 0.85 14.47 0.62 3.69e-37 Tonsillectomy; LUSC cis rs11098499 0.909 rs2127821 chr4:120394535 T/C cg09307838 chr4:120376055 NA 0.8 11.56 0.53 3.14e-26 Corneal astigmatism; LUSC cis rs708547 1.000 rs10003229 chr4:57809598 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.57 -7.11 -0.36 6.87e-12 Response to bleomycin (chromatid breaks); LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.17 -0.32 1.92e-9 Developmental language disorder (linguistic errors); LUSC cis rs7149337 1.000 rs8006432 chr14:51731306 A/T cg23942311 chr14:51606299 NA 0.47 10.33 0.49 6.91e-22 Cancer; LUSC cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.91 -0.35 2.4e-11 Menopause (age at onset); LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg12432903 chr7:1882776 MAD1L1 -0.5 -8.47 -0.42 7.72e-16 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.04 -0.31 4.14e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12995849 0.905 rs7565757 chr2:106452408 T/A cg14210321 chr2:106509881 NCK2 -0.39 -5.81 -0.3 1.42e-8 Addiction; LUSC cis rs9341808 0.935 rs9448894 chr6:80837253 G/T cg08355045 chr6:80787529 NA 0.53 9.39 0.46 9.98e-19 Sitting height ratio; LUSC cis rs4132509 1.000 rs1458024 chr1:243937445 G/C cg21452805 chr1:244014465 NA 0.5 5.71 0.3 2.49e-8 RR interval (heart rate); LUSC cis rs965604 1.000 rs8042260 chr15:78774374 A/G cg18825076 chr15:78729989 IREB2 -0.43 -6.88 -0.35 3.03e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.81 0.3 1.43e-8 Menopause (age at onset); LUSC cis rs231513 0.906 rs11653808 chr17:42005366 A/T cg26893861 chr17:41843967 DUSP3 0.56 5.76 0.3 1.91e-8 Cognitive function; LUSC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg02423579 chr7:2872169 GNA12 0.39 6.14 0.32 2.3e-9 Height; LUSC cis rs10789491 1.000 rs10749863 chr1:47174328 C/T cg15501359 chr1:47185051 KIAA0494 0.82 11.66 0.54 1.34e-26 Response to hepatitis C treatment; LUSC cis rs34779708 0.931 rs55724039 chr10:35465397 A/G cg03585969 chr10:35415529 CREM 0.63 9.25 0.45 2.73e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4481887 0.676 rs7527991 chr1:248527649 T/A cg26353448 chr1:248524236 OR2T4 -0.31 -6.06 -0.31 3.63e-9 Common traits (Other); LUSC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6696846 0.630 rs11240373 chr1:205135600 A/C cg03948781 chr1:205179583 DSTYK 0.31 5.73 0.3 2.23e-8 Red blood cell count; LUSC cis rs6690583 0.623 rs6700723 chr1:85514234 C/T cg11262906 chr1:85462892 MCOLN2 0.67 6.1 0.32 2.99e-9 Serum sulfate level; LUSC cis rs10781543 0.776 rs11145760 chr9:139382594 G/A cg14019695 chr9:139328340 INPP5E 0.52 10.05 0.48 6.06e-21 Monocyte percentage of white cells; LUSC cis rs7923609 0.967 rs3740331 chr10:65192288 G/A cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9560113 1.000 rs9560104 chr13:112174389 A/G cg14154082 chr13:112174009 NA 0.39 7.97 0.4 2.56e-14 Menarche (age at onset); LUSC cis rs9359856 0.564 rs41273329 chr6:90393483 G/A cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.36 -0.42 1.77e-15 Bipolar disorder; LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC cis rs1461503 0.932 rs11218909 chr11:122842613 C/T cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs7659604 0.540 rs4240264 chr4:122683818 A/G cg19748678 chr4:122722346 EXOSC9 -0.39 -5.79 -0.3 1.6e-8 Type 2 diabetes; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg09423085 chr2:68478351 PPP3R1 0.38 6.29 0.33 9.73e-10 Schizophrenia; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg18765753 chr7:1198926 ZFAND2A -0.35 -6.07 -0.32 3.4e-9 Longevity;Endometriosis; LUSC trans rs3806843 0.966 rs10053945 chr5:140160127 C/T cg25815440 chr2:42134162 NA -0.25 -5.96 -0.31 6.49e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs4242434 0.927 rs2291232 chr8:22464064 A/G cg03733263 chr8:22462867 KIAA1967 1.01 18.81 0.72 2.46e-54 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs11098499 0.954 rs13151285 chr4:120314741 C/A cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg07636037 chr3:49044803 WDR6 1.04 18.83 0.72 2.12e-54 Parkinson's disease; LUSC cis rs9329221 0.905 rs28712068 chr8:10251145 G/C cg27411982 chr8:10470053 RP1L1 -0.5 -7.83 -0.39 6.74e-14 Neuroticism; LUSC cis rs17092148 0.616 rs6059908 chr20:33132159 T/C cg16810054 chr20:33298113 TP53INP2 -0.38 -5.95 -0.31 6.73e-9 Neuroticism; LUSC cis rs7829975 0.557 rs7816427 chr8:8545884 T/C cg15556689 chr8:8085844 FLJ10661 -0.51 -7.36 -0.37 1.49e-12 Mood instability; LUSC cis rs10791323 0.569 rs2156679 chr11:133742304 C/T cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC cis rs28647808 0.748 rs28721280 chr9:136267318 C/G cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs508618 0.666 rs480902 chr1:231531627 C/T cg06096015 chr1:231504339 EGLN1 -0.41 -6.08 -0.32 3.29e-9 Red blood cell count; LUSC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg05776053 chr2:74358815 NA 0.4 5.75 0.3 2.01e-8 Gestational age at birth (maternal effect); LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg02475777 chr4:1388615 CRIPAK 0.62 9.0 0.44 1.69e-17 Longevity; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg19626725 chr5:178986131 RUFY1 0.52 8.99 0.44 1.83e-17 Lung cancer; LUSC cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg06784218 chr1:46089804 CCDC17 0.46 8.85 0.44 5.26e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs59698941 0.943 rs10900812 chr5:132268567 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs3947 0.688 rs1293326 chr8:11694765 G/C cg00262122 chr8:11665843 FDFT1 -0.5 -6.29 -0.33 9.82e-10 Blood protein levels; LUSC cis rs11992162 0.573 rs13275808 chr8:11782815 T/C cg21775007 chr8:11205619 TDH -0.41 -5.79 -0.3 1.62e-8 Monocyte count; LUSC cis rs546131 0.928 rs552868 chr11:34830694 G/A cg11058730 chr11:34937778 PDHX;APIP 0.43 5.8 0.3 1.53e-8 Lung disease severity in cystic fibrosis; LUSC trans rs11250098 0.510 rs4840525 chr8:10765635 C/A cg15556689 chr8:8085844 FLJ10661 -0.56 -8.01 -0.4 1.97e-14 Morning vs. evening chronotype; LUSC cis rs765787 0.530 rs3759895 chr15:45543870 G/A cg24006582 chr15:45444508 DUOX1 -0.61 -8.85 -0.44 5.04e-17 Uric acid levels; LUSC trans rs208520 0.690 rs6932475 chr6:66863155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.85 -0.68 1.58e-46 Exhaled nitric oxide output; LUSC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg22433210 chr17:43662623 NA 0.75 10.84 0.51 1.13e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7786808 0.552 rs896762 chr7:158182029 A/G cg01191920 chr7:158217561 PTPRN2 0.49 10.07 0.48 5.27e-21 Obesity-related traits; LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg01879757 chr17:41196368 BRCA1 -0.46 -6.94 -0.36 2e-11 Menopause (age at onset); LUSC cis rs17030434 0.906 rs5020754 chr4:154670444 T/C cg14289246 chr4:154710475 SFRP2 -0.49 -6.46 -0.33 3.8e-10 Electrocardiographic conduction measures; LUSC cis rs17255340 0.520 rs6914164 chr6:84116252 C/T cg08257003 chr6:84140564 ME1 0.36 8.88 0.44 4.2e-17 Platelet-derived growth factor BB levels; LUSC cis rs72772090 0.634 rs17402639 chr5:96107005 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.76 -8.58 -0.42 3.65e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg13535736 chr9:111863775 C9orf5 -0.4 -6.6 -0.34 1.59e-10 Menarche (age at onset); LUSC cis rs3092073 0.669 rs11697323 chr20:44551579 C/T cg27529037 chr20:44575021 PCIF1 0.38 6.71 0.34 8.42e-11 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg09085632 chr11:111637200 PPP2R1B -1.15 -18.41 -0.71 9.52e-53 Primary sclerosing cholangitis; LUSC trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg15704280 chr7:45808275 SEPT13 0.64 7.22 0.37 3.58e-12 Axial length; LUSC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg18876405 chr7:65276391 NA -0.58 -9.5 -0.46 4.35e-19 Aortic root size; LUSC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.02 -0.31 4.72e-9 Crohn's disease; LUSC cis rs2242663 0.798 rs607736 chr11:66328877 G/A cg24851651 chr11:66362959 CCS 0.39 6.34 0.33 7.35e-10 Bipolar disorder; LUSC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg19717773 chr7:2847554 GNA12 -0.4 -6.3 -0.33 9.45e-10 Height; LUSC cis rs10875746 0.903 rs12315625 chr12:48472453 G/A cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs11051970 1.000 rs11051970 chr12:32537488 G/T cg02745156 chr12:32552066 NA 0.44 7.27 0.37 2.59e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6961069 0.585 rs13244883 chr7:80248336 G/T cg04458919 chr7:80252533 CD36 -0.4 -7.02 -0.36 1.25e-11 Platelet count; LUSC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11644478 chr21:40555479 PSMG1 -0.53 -7.83 -0.39 6.32e-14 Menarche (age at onset); LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg24829409 chr8:58192753 C8orf71 0.49 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); LUSC cis rs4888262 0.526 rs4887776 chr16:74635632 A/G cg01733217 chr16:74700730 RFWD3 0.8 13.44 0.59 3.38e-33 Testicular germ cell tumor; LUSC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg03929089 chr4:120376271 NA 0.89 13.93 0.61 4.41e-35 Coronary artery disease; LUSC cis rs6500395 0.926 rs11076570 chr16:48597915 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.94e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.41 0.42 1.21e-15 Height; LUSC trans rs7615952 0.576 rs2276729 chr3:125826214 G/A cg07211511 chr3:129823064 LOC729375 -0.77 -10.01 -0.48 8.21e-21 Blood pressure (smoking interaction); LUSC cis rs2486288 0.656 rs6493144 chr15:45573489 C/G cg09092052 chr15:45571596 NA -0.46 -6.48 -0.33 3.23e-10 Glomerular filtration rate; LUSC cis rs477692 0.789 rs568166 chr10:131400088 G/A cg05714579 chr10:131428358 MGMT 0.47 6.73 0.35 7.53e-11 Response to temozolomide; LUSC cis rs71403859 0.502 rs12919417 chr16:71579711 A/G cg08717414 chr16:71523259 ZNF19 0.68 7.8 0.39 8.17e-14 Post bronchodilator FEV1; LUSC cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg00012203 chr2:219082015 ARPC2 -0.6 -9.77 -0.47 5.39e-20 Ulcerative colitis; LUSC cis rs11190604 1.000 rs1080698 chr10:102295114 G/T cg23241863 chr10:102295624 HIF1AN 0.48 5.9 0.31 9.04e-9 Palmitoleic acid (16:1n-7) levels; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg24597927 chr20:45317651 TP53RK -0.41 -5.99 -0.31 5.51e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg26897989 chr16:1907736 C16orf73 0.4 6.72 0.35 7.69e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs11229555 0.645 rs12794534 chr11:58179568 C/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg03676636 chr4:99064102 C4orf37 0.29 6.37 0.33 6.31e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -11.91 -0.55 1.64e-27 Hemoglobin concentration; LUSC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg12463550 chr7:65579703 CRCP -0.57 -8.54 -0.42 4.88e-16 Aortic root size; LUSC cis rs9325144 0.723 rs3887436 chr12:39189526 A/C cg13010199 chr12:38710504 ALG10B -0.5 -7.5 -0.38 5.89e-13 Morning vs. evening chronotype; LUSC cis rs34779708 0.931 rs11592404 chr10:35273476 G/A cg04310649 chr10:35416472 CREM -0.42 -6.39 -0.33 5.6e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg11050988 chr7:1952600 MAD1L1 -0.3 -5.68 -0.3 2.88e-8 Bipolar disorder and schizophrenia; LUSC cis rs7584330 0.744 rs10929234 chr2:238380034 C/G cg16989719 chr2:238392110 NA 0.49 7.92 0.4 3.64e-14 Prostate cancer; LUSC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.43 -6.79 -0.35 5.04e-11 Alzheimer's disease (late onset); LUSC cis rs2274273 0.624 rs10143136 chr14:55743528 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.72 0.47 7.65e-20 Protein biomarker; LUSC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg03806693 chr22:41940476 POLR3H 0.98 13.46 0.59 2.82e-33 Vitiligo; LUSC trans rs61931739 0.500 rs11052990 chr12:34058647 T/A cg26384229 chr12:38710491 ALG10B 0.72 11.36 0.53 1.66e-25 Morning vs. evening chronotype; LUSC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg22875332 chr1:76189707 ACADM 0.76 13.58 0.6 9.13e-34 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg14552801 chr7:65878734 NA 0.45 6.4 0.33 5.4e-10 Aortic root size; LUSC cis rs12618769 0.597 rs4850876 chr2:99112069 C/T cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs9467773 0.620 rs1027204 chr6:26639613 T/C cg05738196 chr6:26577821 NA 0.78 14.95 0.63 4.82e-39 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg07507251 chr3:52567010 NT5DC2 0.33 6.38 0.33 5.76e-10 Bipolar disorder; LUSC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.6 8.43 0.42 1.05e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.16 0.32 2.08e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.62e-24 Aortic root size; LUSC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg06740227 chr12:86229804 RASSF9 0.37 5.84 0.3 1.27e-8 Major depressive disorder; LUSC cis rs231513 0.954 rs231498 chr17:41975251 C/G cg26893861 chr17:41843967 DUSP3 -0.53 -6.39 -0.33 5.53e-10 Cognitive function; LUSC cis rs7589342 0.517 rs6726571 chr2:106390251 T/C cg09152813 chr2:106391379 NCK2 -0.37 -5.91 -0.31 8.29e-9 Addiction; LUSC cis rs6121246 0.529 rs6060174 chr20:30183538 G/A cg18721089 chr20:30220636 NA -0.39 -6.09 -0.32 3.12e-9 Mean corpuscular hemoglobin; LUSC cis rs1832871 0.711 rs9459887 chr6:158696479 C/T cg07165851 chr6:158734300 TULP4 0.5 7.8 0.39 7.87e-14 Height; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7903847 0.642 rs11189167 chr10:99125722 A/G cg20016023 chr10:99160130 RRP12 -0.3 -6.33 -0.33 7.68e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg00814883 chr7:100076585 TSC22D4 -0.67 -8.81 -0.43 6.75e-17 Platelet count; LUSC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg18825119 chr6:163149453 PACRG;PARK2 -0.34 -6.02 -0.31 4.62e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4906332 1.000 rs2065017 chr14:103879579 T/C cg04998671 chr14:104000505 TRMT61A -0.46 -7.2 -0.37 4.12e-12 Coronary artery disease; LUSC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.35 -6.96 -0.36 1.78e-11 Schizophrenia; LUSC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg12863693 chr15:85201151 NMB 0.35 6.87 0.35 3.09e-11 Schizophrenia; LUSC cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg05283184 chr6:79620031 NA -0.57 -12.12 -0.55 2.99e-28 Intelligence (multi-trait analysis); LUSC cis rs9807989 0.507 rs2293224 chr2:103035779 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.17e-12 Asthma; LUSC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.46 0.59 2.81e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg18404041 chr3:52824283 ITIH1 0.4 6.84 0.35 3.77e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg08270630 chr22:50330655 NA 0.43 6.44 0.33 4.22e-10 Schizophrenia; LUSC cis rs4776059 0.724 rs8030141 chr15:52937689 G/A cg24008177 chr15:52972085 KIAA1370 -0.36 -6.45 -0.33 3.89e-10 Schizophrenia; LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs796364 0.806 rs11691873 chr2:200966337 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.98 -0.4 2.44e-14 Schizophrenia; LUSC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg06637938 chr14:75390232 RPS6KL1 0.54 8.7 0.43 1.53e-16 Height; LUSC cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg22709100 chr7:91322751 NA -0.4 -5.82 -0.3 1.41e-8 Breast cancer; LUSC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg04362960 chr10:104952993 NT5C2 0.59 9.31 0.45 1.7e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg25282410 chr6:160211355 TCP1;MRPL18 -1.2 -20.58 -0.75 2.26e-61 Age-related macular degeneration (geographic atrophy); LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg15383120 chr6:291909 DUSP22 -0.47 -7.22 -0.37 3.44e-12 Menopause (age at onset); LUSC cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg03146154 chr1:46216737 IPP 0.51 7.6 0.38 2.94e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg25233709 chr10:116636983 FAM160B1 0.45 8.11 0.41 9.82e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.63e-8 Breast cancer; LUSC cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg13256891 chr4:100009986 ADH5 -0.44 -6.02 -0.31 4.68e-9 Alcohol dependence; LUSC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg15744005 chr10:104629667 AS3MT -0.4 -8.3 -0.41 2.7e-15 Arsenic metabolism; LUSC cis rs12410462 0.681 rs114950580 chr1:227673334 G/C cg10327440 chr1:227177885 CDC42BPA -0.74 -6.1 -0.32 2.86e-9 Major depressive disorder; LUSC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.03 -0.31 4.32e-9 Lung cancer; LUSC cis rs6690583 0.524 rs6680422 chr1:85451945 C/T cg11262906 chr1:85462892 MCOLN2 0.68 6.6 0.34 1.63e-10 Serum sulfate level; LUSC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs2029213 0.523 rs3773745 chr3:53270424 A/G cg16894138 chr3:53270350 TKT -0.33 -6.98 -0.36 1.55e-11 Heart rate; LUSC cis rs12286929 0.609 rs12791813 chr11:115091510 G/A cg04055981 chr11:115044050 NA 0.37 6.72 0.34 7.98e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg10621924 chr7:39171070 POU6F2 0.49 7.68 0.39 1.75e-13 IgG glycosylation; LUSC cis rs7107174 0.892 rs10899482 chr11:78060081 A/C cg27205649 chr11:78285834 NARS2 -0.51 -5.77 -0.3 1.77e-8 Testicular germ cell tumor; LUSC cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg20848291 chr7:100343083 ZAN 0.39 6.05 0.31 3.89e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.61 0.65 1.25e-41 Platelet count; LUSC cis rs2204008 0.837 rs2127955 chr12:37969194 A/G cg26384229 chr12:38710491 ALG10B 0.81 13.44 0.59 3.28e-33 Bladder cancer; LUSC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs11030122 0.702 rs12281293 chr11:3963814 C/T cg18678763 chr11:4115507 RRM1 -0.46 -6.0 -0.31 5.13e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg12463550 chr7:65579703 CRCP -0.49 -7.03 -0.36 1.18e-11 Aortic root size; LUSC cis rs860295 0.812 rs12024257 chr1:155780536 G/A cg08949192 chr1:155289623 RUSC1;FDPS -0.36 -5.87 -0.31 1.06e-8 Body mass index; LUSC cis rs7258465 1.000 rs4808804 chr19:18585325 A/G cg25828334 chr19:18545568 ISYNA1 -0.37 -6.18 -0.32 1.9e-9 Breast cancer; LUSC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg02269571 chr22:50332266 NA -0.57 -8.4 -0.42 1.26e-15 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06761793 chr1:1550770 MIB2 -0.43 -6.39 -0.33 5.42e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg03264133 chr6:25882463 NA -0.39 -6.82 -0.35 4.24e-11 Height; LUSC cis rs3820068 0.705 rs4646077 chr1:15827136 C/T cg17385448 chr1:15911702 AGMAT 0.37 5.86 0.31 1.08e-8 Systolic blood pressure; LUSC cis rs372883 0.554 rs10154065 chr21:30749480 G/C cg08807101 chr21:30365312 RNF160 0.65 10.48 0.5 2.04e-22 Pancreatic cancer; LUSC cis rs12477438 0.715 rs7586608 chr2:99558017 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.54 -0.5 1.29e-22 Chronic sinus infection; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg12564285 chr5:131593104 PDLIM4 0.45 8.72 0.43 1.31e-16 Blood metabolite levels; LUSC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.43 -0.33 4.29e-10 Total body bone mineral density; LUSC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg05313129 chr8:58192883 C8orf71 -0.53 -6.84 -0.35 3.89e-11 Developmental language disorder (linguistic errors); LUSC cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg22681709 chr2:178499509 PDE11A -0.57 -11.33 -0.53 2.19e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.06e-17 Prudent dietary pattern; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg20821713 chr7:1055600 C7orf50 -0.38 -5.92 -0.31 7.85e-9 Longevity;Endometriosis; LUSC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg03388025 chr16:89894329 SPIRE2 0.33 6.9 0.35 2.65e-11 Vitiligo; LUSC cis rs10779751 0.960 rs4845988 chr1:11319587 A/G cg08854313 chr1:11322531 MTOR 0.91 15.94 0.66 6.12e-43 Body mass index; LUSC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg18350739 chr11:68623251 NA -0.38 -6.79 -0.35 5.16e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11971779 0.680 rs2355787 chr7:139089928 G/T cg23387468 chr7:139079360 LUC7L2 -0.39 -5.99 -0.31 5.43e-9 Diisocyanate-induced asthma; LUSC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg24675658 chr1:53192096 ZYG11B 0.73 12.09 0.55 3.83e-28 Monocyte count; LUSC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg09365446 chr1:150670422 GOLPH3L 0.56 8.55 0.42 4.33e-16 Tonsillectomy; LUSC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg18512352 chr11:47633146 NA -0.48 -9.69 -0.47 9.85e-20 Subjective well-being; LUSC cis rs12310956 0.532 rs11052954 chr12:33993512 C/G cg06521331 chr12:34319734 NA -0.47 -7.57 -0.38 3.56e-13 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.85e-15 Homoarginine levels; LUSC cis rs3540 0.597 rs3539 chr15:91045419 G/T cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.69 -0.3 2.8e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12421382 0.659 rs1837397 chr11:109389803 A/C cg11473876 chr11:109292803 C11orf87 0.4 6.46 0.33 3.7e-10 Schizophrenia; LUSC cis rs3768617 0.510 rs7518957 chr1:183093028 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.67 -10.24 -0.49 1.42e-21 Fuchs's corneal dystrophy; LUSC cis rs6547741 0.935 rs4666005 chr2:27855239 A/G cg27432699 chr2:27873401 GPN1 0.81 15.14 0.64 8.6e-40 Oral cavity cancer; LUSC cis rs35306767 0.623 rs34034003 chr10:1143435 G/A cg26597838 chr10:835615 NA 0.53 6.42 0.33 4.6e-10 Eosinophil percentage of granulocytes; LUSC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg18200150 chr17:30822561 MYO1D -0.43 -8.6 -0.43 3.09e-16 Schizophrenia; LUSC cis rs2197308 0.594 rs9705810 chr12:37895003 G/A cg26384229 chr12:38710491 ALG10B -0.78 -12.61 -0.57 4.4e-30 Morning vs. evening chronotype; LUSC cis rs12760731 0.565 rs12037429 chr1:178224741 C/T cg00404053 chr1:178313656 RASAL2 0.67 6.92 0.35 2.33e-11 Obesity-related traits; LUSC cis rs7267979 0.740 rs2259961 chr20:25282626 T/G cg14121845 chr20:25566513 NINL 0.31 5.77 0.3 1.81e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.36 0.37 1.42e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg08470875 chr2:26401718 FAM59B -0.72 -9.94 -0.48 1.43e-20 Gut microbiome composition (summer); LUSC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.69 -11.23 -0.52 4.84e-25 Total body bone mineral density; LUSC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg20090143 chr19:45452003 APOC2 0.47 9.14 0.45 6.27e-18 Blood protein levels; LUSC cis rs7584330 0.704 rs11884395 chr2:238359366 C/T cg14458575 chr2:238380390 NA 0.76 13.63 0.6 5.84e-34 Prostate cancer; LUSC cis rs10779751 1.000 rs7549109 chr1:11278813 C/G cg08854313 chr1:11322531 MTOR -0.9 -15.72 -0.65 4.54e-42 Body mass index; LUSC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 10.83 0.51 1.24e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs17095355 0.901 rs10884919 chr10:111757791 G/A cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.35 -0.37 1.53e-12 Biliary atresia; LUSC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.96e-11 Blood metabolite levels; LUSC cis rs78663649 0.708 rs115656720 chr19:16622921 C/A cg05286348 chr19:16641544 CHERP -1.34 -10.78 -0.51 1.88e-23 White blood cell count; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg08206623 chr11:2907334 CDKN1C -0.45 -6.75 -0.35 6.59e-11 Cognitive function;Information processing speed; LUSC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg18876405 chr7:65276391 NA -0.56 -8.96 -0.44 2.27e-17 Aortic root size; LUSC cis rs7172118 1 rs7172118 chr15:78862453 C/A cg06917634 chr15:78832804 PSMA4 -0.44 -5.93 -0.31 7.39e-9 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs12893668 0.703 rs4906338 chr14:104050357 A/G cg04998671 chr14:104000505 TRMT61A -0.47 -6.76 -0.35 6.18e-11 Reticulocyte count; LUSC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg21724239 chr8:58056113 NA 0.57 6.83 0.35 3.97e-11 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg09033563 chr22:24373618 LOC391322 -0.47 -6.59 -0.34 1.75e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs79976124 0.837 rs11751145 chr6:66642039 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.67 8.39 0.42 1.37e-15 Type 2 diabetes; LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC trans rs12439619 0.774 rs2867649 chr15:82554672 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.48 -6.48 -0.33 3.35e-10 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg05368731 chr17:41323189 NBR1 0.95 16.07 0.66 1.92e-43 Menopause (age at onset); LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg04267008 chr7:1944627 MAD1L1 -0.62 -9.52 -0.46 3.74e-19 Bipolar disorder and schizophrenia; LUSC cis rs611744 0.647 rs674391 chr8:109242803 A/T cg21045802 chr8:109455806 TTC35 0.42 6.58 0.34 1.77e-10 Dupuytren's disease; LUSC cis rs116988415 0.584 rs78707026 chr14:65249283 A/G cg25083366 chr14:65239357 SPTB 0.62 6.65 0.34 1.21e-10 Daytime sleep phenotypes; LUSC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg03732007 chr1:2071316 PRKCZ 0.59 10.81 0.51 1.54e-23 Height; LUSC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.23e-10 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg05585544 chr11:47624801 NA -0.41 -7.39 -0.37 1.22e-12 Subjective well-being; LUSC cis rs9660992 0.674 rs56198325 chr1:205265450 G/A cg21545522 chr1:205238299 TMCC2 0.48 9.04 0.44 1.26e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12760731 0.565 rs12040475 chr1:178185651 G/A cg00404053 chr1:178313656 RASAL2 0.68 6.9 0.35 2.55e-11 Obesity-related traits; LUSC cis rs9768139 0.708 rs896779 chr7:158113390 T/G cg06219351 chr7:158114137 PTPRN2 -0.54 -9.91 -0.48 1.84e-20 Calcium levels; LUSC cis rs4343996 0.537 rs7791343 chr7:3416780 A/C cg21248987 chr7:3385318 SDK1 0.35 5.79 0.3 1.59e-8 Motion sickness; LUSC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg04450456 chr4:17643702 FAM184B 0.39 6.52 0.34 2.54e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4919694 1.000 rs76255497 chr10:104651955 T/C cg04362960 chr10:104952993 NT5C2 1.1 12.99 0.58 1.63e-31 Arsenic metabolism; LUSC cis rs4654899 0.629 rs7515279 chr1:21172774 C/T cg01072550 chr1:21505969 NA 0.47 7.1 0.36 7.55e-12 Superior frontal gyrus grey matter volume; LUSC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg23172400 chr8:95962367 TP53INP1 -0.3 -5.75 -0.3 2.04e-8 Type 2 diabetes; LUSC cis rs992157 1.000 rs736731 chr2:219120588 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.55 8.29 0.41 2.72e-15 Colorectal cancer; LUSC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg09365446 chr1:150670422 GOLPH3L 0.52 7.47 0.38 6.89e-13 Melanoma; LUSC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs425277 1.000 rs196128 chr1:2078444 T/G cg03732007 chr1:2071316 PRKCZ 0.47 7.62 0.38 2.68e-13 Height; LUSC cis rs612683 0.518 rs565590 chr1:100846956 T/C cg06223162 chr1:101003688 GPR88 0.37 6.88 0.35 3.02e-11 Breast cancer; LUSC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg16624210 chr5:671434 TPPP 0.48 6.05 0.31 3.96e-9 Obesity-related traits; LUSC cis rs16854884 0.770 rs7621079 chr3:143814500 G/C cg06585982 chr3:143692056 C3orf58 0.41 6.14 0.32 2.3e-9 Economic and political preferences (feminism/equality); LUSC cis rs6580649 0.943 rs3803183 chr12:48398080 T/A cg24011408 chr12:48396354 COL2A1 0.55 7.61 0.38 2.78e-13 Lung cancer; LUSC cis rs8016982 0.963 rs7149672 chr14:81657336 A/G cg01989461 chr14:81687754 GTF2A1 0.57 8.47 0.42 7.73e-16 Schizophrenia; LUSC cis rs7246657 0.943 rs4417644 chr19:37852472 A/G cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg03709012 chr19:19516395 GATAD2A 0.85 14.07 0.61 1.21e-35 Tonsillectomy; LUSC cis rs3754214 0.857 rs488271 chr1:150284534 A/G cg15654264 chr1:150340011 RPRD2 -0.45 -7.39 -0.37 1.22e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs10419226 0.511 rs7246437 chr19:18786784 A/G cg22001208 chr19:18782374 NA -0.37 -6.07 -0.32 3.54e-9 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg22997252 chr11:11643842 GALNTL4 0.49 6.04 0.31 4.02e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 7.12 0.36 6.66e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg04518342 chr5:131593106 PDLIM4 0.41 7.26 0.37 2.7e-12 Breast cancer; LUSC cis rs7264396 0.563 rs2425136 chr20:34344782 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -7.35 -0.37 1.53e-12 Total cholesterol levels; LUSC cis rs11190604 1.000 rs1800662 chr10:102289078 C/A cg23241863 chr10:102295624 HIF1AN 0.48 5.74 0.3 2.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs72772090 0.539 rs35898772 chr5:96179685 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.45 -0.33 3.87e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs752010 0.695 rs11210508 chr1:42106935 A/G cg06885757 chr1:42089581 HIVEP3 0.44 8.54 0.42 4.78e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg02187348 chr16:89574699 SPG7 0.49 7.68 0.39 1.73e-13 Multiple myeloma (IgH translocation); LUSC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg22166914 chr1:53195759 ZYG11B -0.61 -10.23 -0.49 1.51e-21 Monocyte count; LUSC cis rs4319547 0.688 rs10847242 chr12:123079020 T/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -6.56 -0.34 2.05e-10 Body mass index; LUSC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -7.79 -0.39 8.44e-14 Type 2 diabetes; LUSC cis rs2839186 0.786 rs7409792 chr21:47691729 C/A cg13012494 chr21:47604986 C21orf56 0.38 5.66 0.3 3.29e-8 Testicular germ cell tumor; LUSC cis rs926938 0.527 rs360594 chr1:115472401 G/A cg12756093 chr1:115239321 AMPD1 0.46 7.04 0.36 1.13e-11 Autism; LUSC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg18827107 chr12:86230957 RASSF9 -0.46 -6.96 -0.36 1.81e-11 Major depressive disorder; LUSC trans rs6089829 0.926 rs6011552 chr20:61667894 T/C cg13615516 chr5:77269221 NA 0.4 6.66 0.34 1.15e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6121246 0.609 rs6060983 chr20:30420924 T/C cg18721089 chr20:30220636 NA -0.33 -6.09 -0.32 3.02e-9 Mean corpuscular hemoglobin; LUSC cis rs6967385 0.560 rs4554369 chr7:12356511 C/T cg20607287 chr7:12443886 VWDE 0.49 7.37 0.37 1.37e-12 Response to taxane treatment (placlitaxel); LUSC cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg03146154 chr1:46216737 IPP 0.57 8.51 0.42 6.03e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs629535 0.814 rs651985 chr8:70054966 G/A cg21567404 chr3:27674614 NA 0.98 15.54 0.65 2.35e-41 Dupuytren's disease; LUSC cis rs9902453 0.780 rs62068621 chr17:28170382 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.73 0.47 7.46e-20 Coffee consumption (cups per day); LUSC cis rs62064224 0.589 rs4523973 chr17:30809455 G/A cg18200150 chr17:30822561 MYO1D 0.31 5.91 0.31 8.66e-9 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01357409 chr2:178128772 NFE2L2 -0.43 -6.36 -0.33 6.48e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9905704 0.681 rs2680710 chr17:56552902 A/G cg19466818 chr17:56409534 MIR142 0.36 6.61 0.34 1.53e-10 Testicular germ cell tumor; LUSC cis rs7647973 0.961 rs4955430 chr3:49378088 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.43 6.49 0.33 3.07e-10 Menarche (age at onset); LUSC cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg03878208 chr11:72483293 STARD10 0.46 6.88 0.35 2.9100000000000002e-11 Body mass index; LUSC cis rs950169 0.649 rs12905952 chr15:84691261 G/A cg17173187 chr15:85201210 NMB 0.4 6.53 0.34 2.43e-10 Schizophrenia; LUSC cis rs7659604 0.643 rs6839375 chr4:122663610 G/C cg06713675 chr4:122721982 EXOSC9 -0.47 -7.28 -0.37 2.47e-12 Type 2 diabetes; LUSC cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg16230307 chr14:35515116 FAM177A1 0.78 10.03 0.48 7.34e-21 Psoriasis; LUSC trans rs2797160 1.000 rs1739373 chr6:126011509 A/G cg05039488 chr6:79577232 IRAK1BP1 0.47 7.0 0.36 1.41e-11 Endometrial cancer; LUSC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg05872129 chr22:39784769 NA -0.6 -11.3 -0.53 2.82e-25 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg24881330 chr22:46731750 TRMU 0.93 10.62 0.5 6.64e-23 LDL cholesterol;Cholesterol, total; LUSC cis rs9399135 0.967 rs4895439 chr6:135318854 A/T cg24558204 chr6:135376177 HBS1L 0.59 9.12 0.45 7.4e-18 Red blood cell count; LUSC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg21984481 chr17:79567631 NPLOC4 -0.68 -14.22 -0.61 3.15e-36 Eye color traits; LUSC cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.25 0.45 2.77e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg21226059 chr5:178986404 RUFY1 -0.67 -12.77 -0.57 1.06e-30 Lung cancer; LUSC cis rs5769707 0.935 rs9616332 chr22:50047678 C/G cg10356904 chr22:49881777 NA -0.32 -7.21 -0.37 3.79e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.9 0.78 1.85e-70 Height; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg06877462 chr1:205807181 PM20D1 -0.41 -7.11 -0.36 6.98e-12 Menarche (age at onset); LUSC cis rs11250097 0.549 rs11784897 chr8:11310442 G/A cg27411982 chr8:10470053 RP1L1 -0.42 -6.03 -0.31 4.46e-9 Neuroticism; LUSC cis rs9473147 0.516 rs9349415 chr6:47551861 T/C cg20196966 chr6:47445060 CD2AP 0.41 5.75 0.3 2.07e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg14668632 chr7:2872130 GNA12 -0.47 -6.58 -0.34 1.85e-10 Height; LUSC cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg08798685 chr6:27730294 NA -0.64 -6.01 -0.31 4.93e-9 Breast cancer; LUSC cis rs2274273 1.000 rs7142704 chr14:55630603 C/A cg04306507 chr14:55594613 LGALS3 0.57 13.27 0.59 1.44e-32 Protein biomarker; LUSC trans rs877282 0.842 rs35117541 chr10:764683 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg17420585 chr12:42539391 GXYLT1 -0.37 -7.08 -0.36 8.62e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4499344 0.521 rs1862214 chr19:33035849 C/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.75 10.16 0.49 2.55e-21 Mean platelet volume; LUSC cis rs500891 0.533 rs1171102 chr6:84198015 C/T cg08257003 chr6:84140564 ME1 0.34 8.36 0.42 1.69e-15 Platelet-derived growth factor BB levels; LUSC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg27068330 chr11:65405492 SIPA1 0.52 6.39 0.33 5.51e-10 Blood pressure (age interaction); LUSC cis rs963731 0.649 rs2888585 chr2:39246683 C/T cg04010122 chr2:39346883 SOS1 -0.82 -5.74 -0.3 2.11e-8 Corticobasal degeneration; LUSC cis rs929354 0.772 rs6459737 chr7:156975136 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg16329197 chr12:53359506 NA -0.63 -8.63 -0.43 2.58e-16 Cancer (pleiotropy); LUSC cis rs7937682 0.602 rs11214036 chr11:111773169 C/T cg09085632 chr11:111637200 PPP2R1B -0.96 -13.74 -0.6 2.31e-34 Primary sclerosing cholangitis; LUSC cis rs7107174 1.000 rs7939352 chr11:78003151 G/A cg02023728 chr11:77925099 USP35 0.46 6.93 0.35 2.19e-11 Testicular germ cell tumor; LUSC cis rs9469578 0.892 rs73743334 chr6:33714094 G/C cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs5769707 0.681 rs739240 chr22:50052607 C/A cg20744362 chr22:50050164 C22orf34 0.39 7.28 0.37 2.41e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg14019146 chr3:50243930 SLC38A3 -0.32 -7.1 -0.36 7.5e-12 Intelligence (multi-trait analysis); LUSC cis rs10140922 0.931 rs4982262 chr14:35822193 C/T cg07166546 chr14:35805898 NA -0.24 -5.89 -0.31 9.42e-9 Hip circumference adjusted for BMI; LUSC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.89 -0.63 7.94e-39 Total body bone mineral density; LUSC cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg22117172 chr7:91764530 CYP51A1 -0.33 -5.87 -0.31 1.04e-8 Breast cancer; LUSC cis rs7605827 0.893 rs7575722 chr2:15597551 G/A cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.55e-18 Educational attainment (years of education); LUSC cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg24642439 chr20:33292090 TP53INP2 -0.51 -7.77 -0.39 9.86e-14 Height; LUSC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC cis rs362272 0.505 rs3129310 chr4:3301388 T/G cg18352616 chr4:3374830 RGS12 0.31 6.27 0.32 1.12e-9 Serum sulfate level; LUSC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg21724239 chr8:58056113 NA 0.82 8.89 0.44 4.02e-17 Developmental language disorder (linguistic errors); LUSC cis rs12681287 0.752 rs4463401 chr8:87250309 C/T cg27223183 chr8:87520930 FAM82B -0.45 -5.76 -0.3 1.87e-8 Caudate activity during reward; LUSC cis rs4363385 0.719 rs6664823 chr1:152933424 A/C cg00922841 chr1:152955080 SPRR1A -0.42 -6.92 -0.35 2.26e-11 Inflammatory skin disease; LUSC cis rs2835872 0.930 rs857974 chr21:39005741 A/G cg20424643 chr21:39039972 KCNJ6 -0.4 -6.09 -0.32 3.15e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg05340658 chr4:99064831 C4orf37 0.63 9.8 0.47 4.15e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1008375 0.863 rs10003291 chr4:17600728 A/C cg04450456 chr4:17643702 FAM184B 0.37 5.97 0.31 6.13e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7106204 0.513 rs7131112 chr11:24249402 A/G ch.11.24196551F chr11:24239977 NA 0.98 11.41 0.53 1.13e-25 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg05585544 chr11:47624801 NA -0.41 -7.26 -0.37 2.75e-12 Subjective well-being; LUSC cis rs3750965 0.920 rs896978 chr11:68828929 G/A cg06818126 chr11:68850279 TPCN2 -0.44 -6.24 -0.32 1.3e-9 Hair color; LUSC cis rs4654899 0.931 rs935917 chr1:21167102 A/T cg01072550 chr1:21505969 NA -0.46 -7.06 -0.36 9.84e-12 Superior frontal gyrus grey matter volume; LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19346786 chr7:2764209 NA -0.46 -7.85 -0.39 5.68e-14 Height; LUSC cis rs478304 0.903 rs546202 chr11:65510024 C/T cg05805236 chr11:65401703 PCNXL3 -0.39 -6.55 -0.34 2.21e-10 Acne (severe); LUSC cis rs17270561 0.609 rs4712970 chr6:25770707 G/A cg17691542 chr6:26056736 HIST1H1C 0.5 6.82 0.35 4.31e-11 Iron status biomarkers; LUSC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg18404041 chr3:52824283 ITIH1 -0.51 -9.76 -0.47 5.98e-20 Bipolar disorder; LUSC cis rs4766566 0.609 rs6490042 chr12:111719060 T/A cg10833066 chr12:111807467 FAM109A 0.52 9.16 0.45 5.27e-18 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC cis rs13089785 1.000 rs13081955 chr3:123600144 A/G cg01860459 chr3:123419554 MYLK 0.34 5.66 0.3 3.22e-8 Intelligence (multi-trait analysis); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg05913197 chr6:166796386 BRP44L 0.48 5.96 0.31 6.34e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg11663144 chr21:46675770 NA -0.41 -7.18 -0.37 4.59e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs765787 0.530 rs1648287 chr15:45516956 T/C cg24006582 chr15:45444508 DUOX1 -0.61 -8.96 -0.44 2.41e-17 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11499772 chr17:79818530 P4HB -0.39 -6.04 -0.31 4e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7607369 0.536 rs13013510 chr2:219667227 A/G cg02176678 chr2:219576539 TTLL4 -0.52 -9.15 -0.45 5.72e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs2051211 1.000 rs2051211 chr3:38559749 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.55 -7.73 -0.39 1.29e-13 QRS duration; LUSC cis rs4631830 0.863 rs57263518 chr10:51519154 A/G cg16070123 chr10:51489643 NA -0.5 -7.95 -0.4 3e-14 Prostate-specific antigen levels; LUSC cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg24642439 chr20:33292090 TP53INP2 0.73 11.55 0.53 3.31e-26 Coronary artery disease; LUSC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg12963246 chr6:28129442 ZNF389 0.52 7.18 0.37 4.53e-12 Depression; LUSC cis rs500891 0.547 rs1170480 chr6:84036345 A/G cg08257003 chr6:84140564 ME1 0.34 8.05 0.4 1.43e-14 Platelet-derived growth factor BB levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg02517558 chr12:53473207 SPRYD3 0.4 6.3 0.33 9.51e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg20607287 chr7:12443886 VWDE -0.59 -6.13 -0.32 2.54e-9 Coronary artery disease; LUSC cis rs7267979 1.000 rs6037099 chr20:25356876 T/G cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2835872 0.965 rs73222307 chr21:39012225 G/A cg20424643 chr21:39039972 KCNJ6 0.39 6.05 0.31 3.87e-9 Electroencephalographic traits in alcoholism; LUSC cis rs11711311 1.000 rs2603789 chr3:113470479 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.92 0.35 2.38e-11 IgG glycosylation; LUSC cis rs7772486 0.837 rs2474354 chr6:146323795 T/A cg23711669 chr6:146136114 FBXO30 0.76 13.09 0.58 6.62e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs7267979 0.604 rs242130 chr20:25594020 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.66 -11.69 -0.54 1.05e-26 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg01528321 chr10:82214614 TSPAN14 0.62 9.08 0.45 9.41e-18 Post bronchodilator FEV1; LUSC cis rs477692 1.000 rs479478 chr10:131428959 G/A cg05714579 chr10:131428358 MGMT 0.51 7.57 0.38 3.65e-13 Response to temozolomide; LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.73 0.54 7.69e-27 Alzheimer's disease; LUSC cis rs72781680 0.898 rs79023848 chr2:24038174 C/A cg20701182 chr2:24300061 SF3B14 0.73 7.42 0.38 9.58e-13 Lymphocyte counts; LUSC cis rs11155671 0.530 rs9968871 chr6:150209196 G/A cg04369109 chr6:150039330 LATS1 -0.41 -5.74 -0.3 2.1e-8 Testicular germ cell tumor; LUSC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.92 -0.4 3.51e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4423214 0.840 rs4435028 chr11:71183690 C/A cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs138918 0.776 rs138938 chr22:43569608 C/A cg08909806 chr22:43548696 TSPO 0.36 6.04 0.31 4.06e-9 Monocyte count; LUSC cis rs7267979 1.000 rs404394 chr20:25447896 A/G cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg02187348 chr16:89574699 SPG7 0.48 7.33 0.37 1.79e-12 Multiple myeloma (IgH translocation); LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.62 0.38 2.63e-13 Bipolar disorder; LUSC cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg03264133 chr6:25882463 NA -0.52 -9.51 -0.46 4.03e-19 Blood metabolite levels; LUSC cis rs2652834 0.718 rs12912721 chr15:63397385 T/C cg05507819 chr15:63340323 TPM1 0.55 7.07 0.36 8.99e-12 HDL cholesterol; LUSC cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs6598955 0.671 rs7551557 chr1:26596614 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.71 -0.3 2.56e-8 Obesity-related traits; LUSC trans rs459571 0.876 rs2520095 chr9:136919568 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.75 -12.41 -0.56 2.38e-29 Platelet distribution width; LUSC cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14442939 chr10:27389572 ANKRD26 -0.81 -8.97 -0.44 2.24e-17 Breast cancer; LUSC cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg08807101 chr21:30365312 RNF160 0.65 10.32 0.49 7.47e-22 Pancreatic cancer; LUSC cis rs34779708 0.966 rs998658 chr10:35408654 A/G cg04310649 chr10:35416472 CREM -0.41 -6.52 -0.34 2.61e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6993244 1 rs6993244 chr8:8863059 C/G cg15556689 chr8:8085844 FLJ10661 0.69 11.03 0.52 2.39e-24 Mean corpuscular hemoglobin; LUSC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg23711669 chr6:146136114 FBXO30 0.86 15.66 0.65 7.86e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.54 -8.12 -0.41 9.05e-15 Lymphocyte counts; LUSC cis rs929354 0.713 rs6946947 chr7:156948787 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg11494091 chr17:61959527 GH2 0.66 13.94 0.61 3.9e-35 Prudent dietary pattern; LUSC cis rs9420 0.925 rs488769 chr11:57450720 A/C cg23127183 chr11:57508653 C11orf31 -0.53 -8.04 -0.4 1.59e-14 Schizophrenia; LUSC cis rs17539620 0.519 rs12665532 chr6:154835182 C/G cg20019720 chr6:154832845 CNKSR3 0.62 9.33 0.45 1.56e-18 Lipoprotein (a) levels; LUSC cis rs6163 0.508 rs12776506 chr10:104532828 A/G cg23093090 chr10:104574429 C10orf26 -0.37 -6.31 -0.33 9.04e-10 Waist circumference;Hip circumference; LUSC cis rs447735 0.587 rs11640702 chr16:89729169 A/G cg01097406 chr16:89675127 NA -0.31 -5.97 -0.31 5.94e-9 Hemoglobin concentration; LUSC cis rs9378688 0.654 rs2505658 chr6:2329626 C/T cg12303981 chr6:2244766 GMDS -0.44 -6.12 -0.32 2.61e-9 Caudate nucleus volume; LUSC cis rs2249625 0.523 rs2496501 chr6:72885364 A/G cg18830697 chr6:72922368 RIMS1 -0.37 -7.38 -0.37 1.25e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg09034736 chr1:150693464 HORMAD1 0.44 6.32 0.33 8.16e-10 Melanoma; LUSC cis rs668210 0.793 rs1786172 chr11:65770658 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.58 7.69 0.39 1.66e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg10295955 chr4:187884368 NA -1.09 -25.02 -0.81 1.41e-78 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg26924012 chr15:45694286 SPATA5L1 1.12 20.31 0.74 2.75e-60 Homoarginine levels; LUSC trans rs9393777 0.778 rs67457459 chr6:27198343 T/G cg06606381 chr12:133084897 FBRSL1 -0.62 -6.42 -0.33 4.69e-10 Intelligence (multi-trait analysis); LUSC cis rs12681287 0.785 rs13263353 chr8:87244582 C/T cg27223183 chr8:87520930 FAM82B -0.46 -5.98 -0.31 5.76e-9 Caudate activity during reward; LUSC cis rs10186029 0.509 rs6733869 chr2:213949073 T/C cg08319019 chr2:214017104 IKZF2 -0.43 -6.25 -0.32 1.28e-9 Systemic sclerosis; LUSC trans rs931812 0.829 rs13266662 chr8:101916156 C/T cg20993868 chr7:22813445 NA 0.5 9.34 0.46 1.43e-18 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs12210905 0.925 rs6920115 chr6:26988417 T/C cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.98 -0.31 5.84e-9 Hip circumference adjusted for BMI; LUSC cis rs870825 0.616 rs7660064 chr4:185617529 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.42 0.59 3.9e-33 Blood protein levels; LUSC cis rs6733011 0.628 rs4850888 chr2:99456946 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.57 -0.34 1.88e-10 Bipolar disorder; LUSC cis rs908922 0.676 rs1123567 chr1:152516023 G/A cg20991723 chr1:152506922 NA 0.49 9.36 0.46 1.17e-18 Hair morphology; LUSC cis rs16912285 0.688 rs12805482 chr11:24346955 C/A ch.11.24196551F chr11:24239977 NA 0.87 8.38 0.42 1.5e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs11018904 0.861 rs4589254 chr11:89963355 A/C cg26138821 chr11:89956704 CHORDC1 0.55 6.69 0.34 9.62e-11 Intelligence (multi-trait analysis); LUSC cis rs3812762 0.879 rs1079452 chr11:8779172 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.37 -6.48 -0.33 3.22e-10 Hypospadias; LUSC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg21862992 chr11:68658383 NA 0.5 8.08 0.4 1.19e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg08736216 chr1:53307985 ZYG11A -0.3 -5.96 -0.31 6.42e-9 Monocyte count; LUSC cis rs7577696 0.719 rs3752916 chr2:32354558 C/T cg02381751 chr2:32503542 YIPF4 -0.44 -6.22 -0.32 1.46e-9 Inflammatory biomarkers; LUSC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg18357526 chr6:26021779 HIST1H4A 0.43 6.41 0.33 5.01e-10 Intelligence (multi-trait analysis); LUSC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg21984481 chr17:79567631 NPLOC4 0.72 15.49 0.65 3.61e-41 Eye color traits; LUSC cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.85 -0.35 3.49e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg06637938 chr14:75390232 RPS6KL1 -0.51 -8.02 -0.4 1.79e-14 Height; LUSC cis rs3008870 0.583 rs11208985 chr1:67464666 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.94 -13.7 -0.6 3.26e-34 Lymphocyte percentage of white cells; LUSC trans rs11039798 0.920 rs8186465 chr11:48796771 T/C cg15704280 chr7:45808275 SEPT13 0.78 7.46 0.38 7.71e-13 Axial length; LUSC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.4 -0.38 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4622329 0.636 rs7976377 chr12:102313507 G/C cg23541617 chr12:102225335 GNPTAB 0.26 5.82 0.3 1.38e-8 Systemic lupus erythematosus; LUSC cis rs11098499 0.562 rs13101722 chr4:120555975 C/A cg09307838 chr4:120376055 NA -0.58 -8.86 -0.44 4.9e-17 Corneal astigmatism; LUSC cis rs9837602 1.000 rs2291495 chr3:99782227 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.37 5.68 0.3 2.98e-8 Breast cancer; LUSC cis rs7180079 0.620 rs3935716 chr15:65035979 A/G cg08069370 chr15:64387884 SNX1 0.52 5.77 0.3 1.83e-8 Monocyte count; LUSC cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg05472934 chr7:22766657 IL6 0.44 6.95 0.36 1.93e-11 Lung cancer; LUSC cis rs9361491 0.657 rs9352625 chr6:79454754 G/A cg05283184 chr6:79620031 NA -0.32 -5.91 -0.31 8.65e-9 Intelligence (multi-trait analysis); LUSC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg00745463 chr17:30367425 LRRC37B -0.71 -8.64 -0.43 2.39e-16 Hip circumference adjusted for BMI; LUSC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08018356 chr19:36706053 ZNF146;ZNF565 0.41 6.48 0.33 3.21e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14240646 chr10:27532245 ACBD5 -0.65 -7.75 -0.39 1.15e-13 Breast cancer; LUSC cis rs1790761 0.587 rs4930431 chr11:67294308 C/T cg24690094 chr11:67383802 NA -0.34 -6.42 -0.33 4.6e-10 Mean corpuscular volume; LUSC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg11812906 chr14:75593930 NEK9 0.65 11.16 0.52 8.81e-25 Height; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg00024416 chr22:24240387 NA 0.33 5.7 0.3 2.63e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs68170813 0.563 rs6979198 chr7:107197694 T/G cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.7 -0.3 2.7e-8 Coronary artery disease; LUSC cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg23583168 chr7:148888333 NA -0.92 -17.33 -0.69 1.88e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7089973 0.604 rs7903663 chr10:116609904 G/A cg23260525 chr10:116636907 FAM160B1 0.44 9.34 0.46 1.38e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs6952808 0.656 rs12699646 chr7:2093162 T/G cg04565464 chr8:145669602 NFKBIL2 -0.38 -6.27 -0.32 1.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg18765753 chr7:1198926 ZFAND2A -0.38 -6.83 -0.35 3.96e-11 Longevity;Endometriosis; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg10150615 chr22:24372951 LOC391322 0.43 7.3 0.37 2.13e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg23630131 chr7:65973040 NA -0.21 -5.91 -0.31 8.39e-9 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11179286 chr13:115047994 UPF3A -0.45 -6.01 -0.31 4.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs1215050 0.740 rs804051 chr4:98935935 A/T cg05340658 chr4:99064831 C4orf37 -0.47 -7.44 -0.38 8.76e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7100689 0.753 rs1361458 chr10:82090339 A/T cg01528321 chr10:82214614 TSPAN14 0.97 14.76 0.63 2.7e-38 Post bronchodilator FEV1; LUSC cis rs7123876 0.541 rs61895574 chr11:72347988 A/T cg03713592 chr11:72463424 ARAP1 0.69 6.9 0.35 2.69e-11 Body mass index; LUSC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg06238570 chr21:40685208 BRWD1 -0.55 -8.58 -0.42 3.69e-16 Menarche (age at onset); LUSC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg13628971 chr7:2884303 GNA12 0.46 6.33 0.33 8.02e-10 Height; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg25767906 chr1:53392781 SCP2 -0.63 -12.44 -0.56 1.82e-29 Monocyte count; LUSC cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg21466736 chr12:48725269 NA -0.33 -5.76 -0.3 1.92e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg12379764 chr21:47803548 PCNT -0.41 -5.73 -0.3 2.26e-8 Testicular germ cell tumor; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9902453 1.000 rs4581755 chr17:28427898 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.62 0.43 2.79e-16 Coffee consumption (cups per day); LUSC cis rs754133 0.891 rs12426399 chr12:54419910 G/T cg10005224 chr12:54424964 HOXC4;HOXC5 0.42 8.28 0.41 2.94e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs2120019 0.567 rs8037152 chr15:75156996 A/T cg09165964 chr15:75287851 SCAMP5 -0.91 -10.98 -0.51 3.82e-24 Blood trace element (Zn levels); LUSC cis rs10782582 0.532 rs12132503 chr1:76137762 C/G cg22875332 chr1:76189707 ACADM -0.41 -6.18 -0.32 1.91e-9 Daytime sleep phenotypes; LUSC cis rs1185460 0.967 rs1784459 chr11:118938388 C/A cg23280166 chr11:118938394 VPS11 0.48 7.64 0.39 2.27e-13 Coronary artery disease; LUSC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg22834771 chr12:69754056 YEATS4 -0.49 -7.37 -0.37 1.31e-12 Blood protein levels; LUSC cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg05347473 chr6:146136440 FBXO30 0.5 8.69 0.43 1.61e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg20701182 chr2:24300061 SF3B14 0.87 11.4 0.53 1.19e-25 Lymphocyte counts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20332866 chr1:100678932 DBT 0.58 8.49 0.42 7.03e-16 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7903847 0.544 rs61861865 chr10:99144867 C/G cg08345082 chr10:99160200 RRP12 -0.36 -7.3 -0.37 2.19e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg06454157 chr6:167490870 NA 0.25 6.17 0.32 1.96e-9 Crohn's disease; LUSC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg03526776 chr6:41159608 TREML2 0.33 6.19 0.32 1.74e-9 Alzheimer's disease (late onset); LUSC cis rs9905704 0.647 rs12940492 chr17:56954655 C/G cg12560992 chr17:57184187 TRIM37 0.59 9.47 0.46 5.35e-19 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg17366294 chr4:99064904 C4orf37 0.59 10.39 0.49 4.24e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg02269571 chr22:50332266 NA -0.58 -8.67 -0.43 1.97e-16 Schizophrenia; LUSC cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg26384229 chr12:38710491 ALG10B 0.64 10.05 0.48 5.93e-21 Morning vs. evening chronotype; LUSC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg07701084 chr6:150067640 NUP43 0.56 8.51 0.42 6.04e-16 Lung cancer; LUSC cis rs138229 0.506 rs9628282 chr22:50534952 G/T cg16473166 chr22:50639996 SELO 0.51 6.55 0.34 2.14e-10 Behavioural disinhibition (generation interaction); LUSC cis rs61931739 0.517 rs7958856 chr12:34294737 T/C cg06521331 chr12:34319734 NA -0.47 -7.82 -0.39 7.04e-14 Morning vs. evening chronotype; LUSC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg15212455 chr7:39170539 POU6F2 0.65 11.47 0.53 6.57e-26 IgG glycosylation; LUSC cis rs654950 0.934 rs665223 chr1:42000654 A/T cg06885757 chr1:42089581 HIVEP3 -0.44 -8.22 -0.41 4.47e-15 Airway imaging phenotypes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18903719 chr5:133340536 VDAC1 -0.4 -6.01 -0.31 4.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg25039879 chr17:56429692 SUPT4H1 0.75 10.42 0.5 3.2800000000000002e-22 Cognitive test performance; LUSC cis rs7189233 0.513 rs8044091 chr16:53520998 T/C cg09728985 chr16:53543985 NA -0.31 -5.84 -0.3 1.26e-8 Intelligence (multi-trait analysis); LUSC trans rs208520 0.690 rs10455194 chr6:66743356 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.82 0.68 2.11e-46 Exhaled nitric oxide output; LUSC cis rs9300255 0.620 rs1716173 chr12:123660721 A/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.09 -0.32 3.03e-9 Neutrophil percentage of white cells; LUSC cis rs9653442 0.527 rs2164712 chr2:100745404 C/G cg07810366 chr2:100720526 AFF3 -0.43 -7.2 -0.37 3.95e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7605827 0.897 rs13022830 chr2:15696542 T/C cg19274914 chr2:15703543 NA 0.45 8.6 0.43 3.1e-16 Educational attainment (years of education); LUSC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.89 0.48 2.12e-20 Major depressive disorder; LUSC cis rs12618769 0.597 rs3754879 chr2:99164541 G/T cg10123293 chr2:99228465 UNC50 0.5 8.21 0.41 4.78e-15 Bipolar disorder; LUSC cis rs8092503 0.903 rs12970424 chr18:52472982 G/A cg12377874 chr18:52495404 RAB27B 0.33 5.97 0.31 6.2e-9 Childhood body mass index; LUSC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg03351412 chr1:154909251 PMVK -0.48 -7.45 -0.38 7.95e-13 Prostate cancer; LUSC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg01503450 chr10:980765 NA -0.39 -6.04 -0.31 4.12e-9 Eosinophil percentage of granulocytes; LUSC cis rs1448094 0.690 rs7132879 chr12:86289864 A/G cg25456477 chr12:86230367 RASSF9 0.4 6.87 0.35 3.2e-11 Major depressive disorder; LUSC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg11764359 chr7:65958608 NA 0.69 11.16 0.52 8.79e-25 Aortic root size; LUSC cis rs2486288 0.656 rs11629859 chr15:45547121 T/G cg26924012 chr15:45694286 SPATA5L1 -0.7 -9.99 -0.48 9.74e-21 Glomerular filtration rate; LUSC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg09267113 chr7:98030324 BAIAP2L1 0.39 5.96 0.31 6.4e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11190604 0.767 rs7076606 chr10:102192267 T/C cg07080220 chr10:102295463 HIF1AN 0.61 8.14 0.41 8.11e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg18305652 chr10:134549665 INPP5A 0.44 6.68 0.34 9.79e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg14004847 chr7:1930337 MAD1L1 -0.53 -7.73 -0.39 1.31e-13 Bipolar disorder and schizophrenia; LUSC cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg23583168 chr7:148888333 NA -0.9 -16.73 -0.68 4.51e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7264396 0.943 rs1810742 chr20:34109718 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.47 -0.33 3.57e-10 Total cholesterol levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01153979 chr6:79577195 IRAK1BP1 -0.47 -6.15 -0.32 2.25e-9 Bipolar disorder and schizophrenia; LUSC cis rs6674970 1.000 rs4970941 chr1:151068546 A/G cg11822372 chr1:151115635 SEMA6C 0.54 8.28 0.41 3.01e-15 Childhood ear infection; LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs7824557 0.583 rs2736292 chr8:11234500 A/T cg15556689 chr8:8085844 FLJ10661 0.52 8.09 0.4 1.12e-14 Retinal vascular caliber; LUSC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg08847533 chr14:75593920 NEK9 -0.8 -13.94 -0.61 4e-35 Height; LUSC cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg26395211 chr5:140044315 WDR55 -0.38 -5.78 -0.3 1.76e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg22535103 chr8:58192502 C8orf71 -0.58 -7.09 -0.36 8.19e-12 Developmental language disorder (linguistic errors); LUSC cis rs11229555 0.609 rs12575080 chr11:58224917 A/G cg15696309 chr11:58395628 NA -0.68 -8.26 -0.41 3.34e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7582180 0.652 rs12997725 chr2:100935136 A/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.49 -0.42 6.65e-16 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg21535247 chr6:8435926 SLC35B3 0.58 9.05 0.44 1.22e-17 Motion sickness; LUSC cis rs921968 0.643 rs62191565 chr2:219482017 C/T cg02176678 chr2:219576539 TTLL4 0.6 10.94 0.51 5.22e-24 Mean corpuscular hemoglobin concentration; LUSC trans rs1493916 0.905 rs9956315 chr18:31405546 G/C cg27147174 chr7:100797783 AP1S1 -0.63 -10.28 -0.49 1.01e-21 Life satisfaction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03802069 chr3:137482593 SOX14 0.44 6.98 0.36 1.57e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6541297 1.000 rs2352723 chr1:230291868 C/T cg20703242 chr1:230279135 GALNT2 -0.63 -9.14 -0.45 5.99e-18 Coronary artery disease; LUSC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2262909 0.849 rs2666447 chr19:22132868 T/A cg11619707 chr19:22235551 ZNF257 -0.38 -5.66 -0.3 3.3e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4566357 1.000 rs3820926 chr2:227926621 G/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.89 -0.31 9.43e-9 Coronary artery disease; LUSC cis rs6120849 0.754 rs3818253 chr20:33596876 C/T cg24642439 chr20:33292090 TP53INP2 0.58 6.44 0.33 4.11e-10 Protein C levels; LUSC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.0 0.58 1.44e-31 Cognitive test performance; LUSC cis rs7100689 0.622 rs4536152 chr10:82119242 C/T cg00277334 chr10:82204260 NA -0.54 -8.02 -0.4 1.81e-14 Post bronchodilator FEV1; LUSC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg16362232 chr11:430036 ANO9 0.66 8.29 0.41 2.74e-15 Body mass index; LUSC cis rs2288073 0.965 rs10173173 chr2:24415461 G/T cg06627628 chr2:24431161 ITSN2 0.79 11.53 0.53 4.1e-26 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs7385804 0.761 rs576236 chr7:100316975 C/T cg20848291 chr7:100343083 ZAN 0.4 6.37 0.33 6.35e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg00012203 chr2:219082015 ARPC2 0.6 9.81 0.47 3.91e-20 Ulcerative colitis; LUSC cis rs7671900 0.965 rs9996312 chr4:88285222 T/A cg23841344 chr4:88312519 HSD17B11 -0.42 -6.19 -0.32 1.72e-9 Intelligence (multi-trait analysis); LUSC cis rs362272 0.524 rs2857982 chr4:3358665 G/A cg14583973 chr4:3374767 RGS12 0.37 8.05 0.4 1.48e-14 Serum sulfate level; LUSC cis rs9420 0.528 rs73480556 chr11:57400462 G/C cg23127183 chr11:57508653 C11orf31 -0.45 -6.25 -0.32 1.28e-9 Schizophrenia; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg11843238 chr5:131593191 PDLIM4 0.5 8.81 0.43 6.71e-17 Acylcarnitine levels; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg26419426 chr5:110074663 SLC25A46 0.36 6.18 0.32 1.86e-9 Metabolite levels (Pyroglutamine); LUSC cis rs939658 0.805 rs35484723 chr15:79441032 A/G cg17916960 chr15:79447300 NA -0.53 -10.65 -0.5 5.21e-23 Refractive error; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg04085039 chr16:1712707 CRAMP1L -0.41 -6.6 -0.34 1.66e-10 N-glycan levels; LUSC cis rs921968 0.565 rs6733892 chr2:219616002 C/A cg02176678 chr2:219576539 TTLL4 -0.55 -9.83 -0.47 3.42e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06022373 chr22:39101656 GTPBP1 0.7 10.88 0.51 8.72e-24 Menopause (age at onset); LUSC cis rs6977660 0.714 rs6945533 chr7:19813913 G/C cg05791153 chr7:19748676 TWISTNB 0.7 7.45 0.38 8.29e-13 Thyroid stimulating hormone; LUSC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg22862634 chr11:62369728 EML3;MTA2 0.48 6.9 0.35 2.64e-11 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs3849570 0.643 rs6548779 chr3:81968512 A/G cg07356753 chr3:81810745 GBE1 -0.49 -7.23 -0.37 3.34e-12 Waist circumference;Body mass index; LUSC cis rs72781680 0.898 rs72796152 chr2:23933626 G/A cg08917208 chr2:24149416 ATAD2B 0.89 9.65 0.47 1.31e-19 Lymphocyte counts; LUSC cis rs748404 0.723 rs11853991 chr15:43557549 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.66 0.3 3.31e-8 Lung cancer; LUSC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg12927641 chr6:109611667 NA -0.43 -7.59 -0.38 3.15e-13 Reticulocyte fraction of red cells; LUSC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg22800045 chr5:56110881 MAP3K1 0.79 10.33 0.49 6.92e-22 Initial pursuit acceleration; LUSC trans rs11098499 0.954 rs6857105 chr4:120222298 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.11 0.32 2.82e-9 Corneal astigmatism; LUSC trans rs6502050 0.835 rs6502079 chr17:80124454 T/A cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs6496044 0.568 rs7166642 chr15:86061271 A/G cg13263323 chr15:86062960 AKAP13 -0.38 -6.23 -0.32 1.38e-9 Interstitial lung disease; LUSC trans rs853679 0.607 rs13204012 chr6:28201531 G/A cg01620082 chr3:125678407 NA -0.86 -7.5 -0.38 5.97e-13 Depression; LUSC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg21285383 chr16:89894308 SPIRE2 0.35 7.55 0.38 4.22e-13 Vitiligo; LUSC cis rs77106637 0.556 rs7123876 chr11:72444583 T/C cg03878208 chr11:72483293 STARD10 0.49 7.23 0.37 3.4e-12 Type 2 diabetes; LUSC cis rs9611519 0.780 rs1535048 chr22:41684093 C/T cg03806693 chr22:41940476 POLR3H -0.59 -8.62 -0.43 2.81e-16 Neuroticism; LUSC cis rs6840360 0.550 rs4696269 chr4:152481704 T/A cg22705602 chr4:152727874 NA -0.33 -6.61 -0.34 1.53e-10 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg13395646 chr4:1353034 KIAA1530 -0.65 -10.74 -0.51 2.5e-23 Obesity-related traits; LUSC cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg00701064 chr4:6280414 WFS1 0.5 10.51 0.5 1.58e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs4252134 0.959 rs4252096 chr6:161134273 C/G cg07697006 chr5:132202367 UQCRQ -0.43 -6.03 -0.31 4.34e-9 Giant cell arteritis; LUSC cis rs10752881 1.000 rs4402094 chr1:182986441 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs67981189 0.513 rs7154395 chr14:71566300 G/A cg15816911 chr14:71606274 NA 0.33 5.78 0.3 1.68e-8 Schizophrenia; LUSC cis rs3741151 1.000 rs79778136 chr11:73041339 T/C cg17517138 chr11:73019481 ARHGEF17 1.07 9.19 0.45 4.24e-18 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs8179 0.645 rs66939011 chr7:92265798 T/C cg15732164 chr7:92237376 CDK6 -0.4 -5.67 -0.3 3.06e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs9494145 1.000 rs9494145 chr6:135432552 T/C cg22676075 chr6:135203613 NA 0.62 8.15 0.41 7.39e-15 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg10253484 chr15:75165896 SCAMP2 -0.47 -6.61 -0.34 1.52e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg15790184 chr11:494944 RNH1 0.58 6.26 0.32 1.18e-9 Body mass index; LUSC cis rs7100689 0.646 rs1538815 chr10:82137670 A/G cg00277334 chr10:82204260 NA -0.51 -7.56 -0.38 3.83e-13 Post bronchodilator FEV1; LUSC cis rs6964587 0.967 rs10248102 chr7:91699779 G/A cg22709100 chr7:91322751 NA 0.39 5.75 0.3 1.98e-8 Breast cancer; LUSC cis rs9807989 0.801 rs7558339 chr2:102970243 T/G cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.05 -0.36 1.05e-11 Major depressive disorder; LUSC cis rs2486288 0.656 rs1719232 chr15:45572072 A/G cg26924012 chr15:45694286 SPATA5L1 -0.75 -11.11 -0.52 1.3e-24 Glomerular filtration rate; LUSC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg12463550 chr7:65579703 CRCP -0.46 -6.57 -0.34 1.93e-10 Aortic root size; LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -8.2 -0.41 5.17e-15 Lymphocyte counts; LUSC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg22029157 chr1:209979665 IRF6 0.75 9.2 0.45 4e-18 Cleft lip with or without cleft palate; LUSC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.72 0.3 2.4e-8 Life satisfaction; LUSC cis rs11997175 0.740 rs4467902 chr8:33693415 G/T ch.8.33884649F chr8:33765107 NA 0.37 5.8 0.3 1.5e-8 Body mass index; LUSC cis rs870825 0.587 rs6826883 chr4:185616167 A/C cg04058563 chr4:185651563 MLF1IP 0.87 13.5 0.59 1.86e-33 Blood protein levels; LUSC cis rs709400 0.663 rs7158822 chr14:103887868 C/T cg10523860 chr14:103875565 MARK3 -0.4 -6.38 -0.33 6.08e-10 Body mass index; LUSC cis rs4595586 0.545 rs11610886 chr12:39390613 C/G cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.71 12.0 0.55 7.98e-28 Prudent dietary pattern; LUSC cis rs12618769 0.597 rs3754885 chr2:99121708 G/T cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.82 0.35 4.17e-11 Platelet count; LUSC cis rs924607 0.966 rs1621827 chr5:635074 A/G cg09021430 chr5:549028 NA -0.42 -7.49 -0.38 6.29e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg12310025 chr6:25882481 NA 0.41 6.82 0.35 4.18e-11 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09687332 chr3:49977370 RBM6 0.84 6.62 0.34 1.46e-10 Cognitive performance; LUSC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg22535103 chr8:58192502 C8orf71 -0.67 -7.55 -0.38 4.15e-13 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg08270630 chr22:50330655 NA -0.42 -6.29 -0.33 1e-9 Schizophrenia; LUSC cis rs16937 0.711 rs12129162 chr1:205164650 A/G cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg03477792 chr4:77819574 ANKRD56 0.56 7.66 0.39 2.09e-13 Emphysema distribution in smoking; LUSC cis rs7617773 0.963 rs12495221 chr3:48179178 C/T cg20734569 chr3:48348370 SPINK8 0.44 7.93 0.4 3.25e-14 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17105604 chr19:10764573 ILF3;LOC147727 -0.41 -6.09 -0.32 3.17e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1153858 1.000 rs1346266 chr15:45694516 G/T cg14582100 chr15:45693742 SPATA5L1 0.56 10.09 0.48 4.45e-21 Homoarginine levels; LUSC trans rs10098647 0.632 rs10091445 chr8:61106834 G/C cg09970348 chr3:183978600 ECE2;CAMK2N2 0.46 6.33 0.33 7.92e-10 Obesity-related traits; LUSC cis rs9660992 0.710 rs1172138 chr1:205246019 G/A cg21643547 chr1:205240462 TMCC2 -0.51 -9.61 -0.47 1.82e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2404602 0.647 rs35710279 chr15:77082234 T/A cg23625390 chr15:77176239 SCAPER -0.66 -9.86 -0.47 2.61e-20 Blood metabolite levels; LUSC cis rs10504229 1.000 rs57378064 chr8:58169844 C/G cg22535103 chr8:58192502 C8orf71 -0.75 -9.49 -0.46 4.42e-19 Developmental language disorder (linguistic errors); LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 5.01e-10 Systemic lupus erythematosus; LUSC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg11062466 chr8:58055876 NA 0.43 5.77 0.3 1.81e-8 Developmental language disorder (linguistic errors); LUSC cis rs2070433 0.539 rs2839312 chr21:47958225 T/C cg12379764 chr21:47803548 PCNT 0.79 12.05 0.55 5.1e-28 Lymphocyte counts; LUSC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.83 -0.39 6.56e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs12824058 0.831 rs7979497 chr12:130804706 C/T cg24838063 chr12:130822603 PIWIL1 0.67 10.45 0.5 2.57e-22 Menopause (age at onset); LUSC cis rs9815354 0.857 rs1474219 chr3:42000913 G/A cg03022575 chr3:42003672 ULK4 -0.51 -5.72 -0.3 2.37e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.22 0.37 3.64e-12 Cognitive ability; LUSC cis rs62103177 0.810 rs62103197 chr18:77632923 G/A cg20368463 chr18:77673604 PQLC1 0.69 5.93 0.31 7.62e-9 Opioid sensitivity; LUSC cis rs6696846 0.777 rs2369526 chr1:205054406 C/T cg21643547 chr1:205240462 TMCC2 -0.36 -6.74 -0.35 7.08e-11 Red blood cell count; LUSC cis rs9815354 0.812 rs17215183 chr3:41812334 T/C cg03022575 chr3:42003672 ULK4 0.85 8.67 0.43 1.87e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7267979 0.527 rs6076369 chr20:25576783 G/A cg03522245 chr20:25566470 NINL -0.39 -6.09 -0.32 3.1e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6845621 0.717 rs4696962 chr4:18873031 T/C cg12196642 chr4:18937545 NA -0.32 -6.04 -0.31 4.06e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs951366 0.538 rs3761919 chr1:205694720 G/A cg14893161 chr1:205819251 PM20D1 -0.47 -6.41 -0.33 4.93e-10 Menarche (age at onset); LUSC cis rs9309473 0.948 rs7607892 chr2:73818707 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.76 -0.35 6.28e-11 Metabolite levels; LUSC cis rs4499344 0.730 rs614370 chr19:33106390 T/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.93 0.58 2.86e-31 Mean platelet volume; LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg03576123 chr11:487126 PTDSS2 -0.95 -10.4 -0.49 3.94e-22 Body mass index; LUSC cis rs9362426 0.708 rs4707365 chr6:88100912 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.37 6.15 0.32 2.16e-9 Depressive episodes in bipolar disorder; LUSC cis rs66887589 0.870 rs59590064 chr4:120539753 T/C cg09307838 chr4:120376055 NA -0.49 -7.48 -0.38 6.83e-13 Diastolic blood pressure; LUSC cis rs7191439 0.858 rs8050715 chr16:88780923 C/G cg27087555 chr16:88793112 FAM38A -1.27 -12.67 -0.57 2.56e-30 Plateletcrit; LUSC cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg25258033 chr6:167368657 RNASET2 0.39 6.39 0.33 5.72e-10 Crohn's disease; LUSC cis rs13385 0.769 rs10477333 chr5:139617885 T/C cg26211634 chr5:139558579 C5orf32 0.45 7.02 0.36 1.21e-11 Atrial fibrillation; LUSC cis rs2274273 0.870 rs3825616 chr14:55853288 G/C cg04306507 chr14:55594613 LGALS3 0.56 12.76 0.57 1.24e-30 Protein biomarker; LUSC cis rs2952156 0.920 rs14050 chr17:37828072 C/T cg00129232 chr17:37814104 STARD3 -0.45 -6.57 -0.34 1.93e-10 Asthma; LUSC cis rs240993 0.595 rs3777910 chr6:111902451 G/A cg22127309 chr6:111907043 TRAF3IP2 0.34 6.09 0.32 3.07e-9 Inflammatory skin disease;Psoriasis; LUSC trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg21153622 chr11:89784906 NA -0.39 -6.0 -0.31 5.21e-9 HDL cholesterol; LUSC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.13 0.32 2.52e-9 Menopause (age at onset); LUSC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg06634786 chr22:41940651 POLR3H 0.56 6.5 0.34 2.87e-10 Vitiligo; LUSC cis rs936229 1.000 rs936228 chr15:75132164 T/C cg10253484 chr15:75165896 SCAMP2 -0.51 -6.67 -0.34 1.03e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs16976116 0.901 rs9920219 chr15:55503964 T/C cg11288833 chr15:55489084 RSL24D1 0.5 5.92 0.31 7.84e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4803468 0.967 rs13345590 chr19:41886455 T/G cg09537434 chr19:41945824 ATP5SL -0.88 -15.47 -0.65 4.51e-41 Height; LUSC cis rs644799 0.582 rs473157 chr11:95596874 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.59 8.91 0.44 3.32e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4478858 0.735 rs10798845 chr1:31822636 A/G cg00250761 chr1:31883323 NA 0.37 9.26 0.45 2.57e-18 Alcohol dependence; LUSC cis rs4746818 1.000 rs4284308 chr10:70884861 C/T cg11621586 chr10:70884670 VPS26A 1.12 14.08 0.61 1.17e-35 Left atrial antero-posterior diameter; LUSC cis rs6012953 0.874 rs2426159 chr20:49173179 C/T cg13958625 chr20:49123093 NA -0.27 -6.08 -0.32 3.22e-9 Vitiligo; LUSC cis rs6987853 0.830 rs4737048 chr8:42359035 G/T cg09913449 chr8:42400586 C8orf40 -0.41 -6.78 -0.35 5.36e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs9341808 0.718 rs10080237 chr6:80854470 T/C cg08355045 chr6:80787529 NA 0.57 9.9 0.48 1.96e-20 Sitting height ratio; LUSC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg03264133 chr6:25882463 NA 0.41 7.0 0.36 1.39e-11 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs2777491 0.915 rs9302109 chr15:41612180 G/T cg18705301 chr15:41695430 NDUFAF1 -0.73 -13.36 -0.59 6.47e-33 Ulcerative colitis; LUSC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.77 0.3 1.81e-8 Intelligence (multi-trait analysis); LUSC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg16447950 chr5:562315 NA -0.47 -6.36 -0.33 6.8e-10 Obesity-related traits; LUSC cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg02527881 chr3:46936655 PTH1R -0.39 -6.79 -0.35 5.04e-11 Colorectal cancer; LUSC cis rs11098499 0.554 rs2175381 chr4:120265967 T/C cg24375607 chr4:120327624 NA 0.69 10.92 0.51 6.06e-24 Corneal astigmatism; LUSC cis rs9322193 0.923 rs4870052 chr6:150161114 G/A cg13206674 chr6:150067644 NUP43 0.55 8.28 0.41 3.02e-15 Lung cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03577460 chr14:24836084 NFATC4 0.41 5.99 0.31 5.34e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg09955084 chr16:413813 NA 0.29 6.32 0.33 8.32e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.45 -6.54 -0.34 2.34e-10 Menarche (age at onset); LUSC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs5769765 0.908 rs7410601 chr22:50317187 C/T cg26441486 chr22:50317300 CRELD2 0.53 7.75 0.39 1.1e-13 Schizophrenia; LUSC cis rs983392 0.667 rs632185 chr11:59951433 A/G cg20284999 chr11:59952153 MS4A6A 0.35 6.21 0.32 1.58e-9 Alzheimer's disease (late onset); LUSC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 11.21 0.52 5.84e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg09491104 chr22:46646882 C22orf40 -0.64 -7.28 -0.37 2.46e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg22782873 chr19:19639568 YJEFN3 -0.54 -6.58 -0.34 1.82e-10 Bipolar disorder; LUSC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg27572855 chr1:25598939 RHD 0.41 7.26 0.37 2.7e-12 Erythrocyte sedimentation rate; LUSC cis rs12318506 0.826 rs35933860 chr12:75731821 A/G cg04728562 chr12:75699417 CAPS2 -0.84 -5.91 -0.31 8.43e-9 Coronary artery calcification; LUSC cis rs4343996 0.566 rs6971287 chr7:3396180 T/G cg21248987 chr7:3385318 SDK1 -0.35 -5.79 -0.3 1.67e-8 Motion sickness; LUSC cis rs9527 0.590 rs763914 chr10:104841587 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.52 0.46 3.52e-19 Arsenic metabolism; LUSC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg13683864 chr3:40499215 RPL14 -0.94 -16.74 -0.68 4.21e-46 Renal cell carcinoma; LUSC cis rs66887589 0.627 rs3872807 chr4:120360251 T/A cg24375607 chr4:120327624 NA 0.49 7.55 0.38 4.15e-13 Diastolic blood pressure; LUSC cis rs10435719 0.773 rs7842810 chr8:11794163 A/G cg21775007 chr8:11205619 TDH 0.47 6.66 0.34 1.11e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg11793168 chr2:37415747 SULT6B1 0.42 6.18 0.32 1.89e-9 Cognitive function;Information processing speed; LUSC cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg10518543 chr12:38710700 ALG10B 0.44 6.12 0.32 2.58e-9 Morning vs. evening chronotype; LUSC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg22800045 chr5:56110881 MAP3K1 0.48 6.19 0.32 1.73e-9 Coronary artery disease; LUSC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.7 0.3 2.64e-8 Hip circumference adjusted for BMI; LUSC cis rs2289583 0.573 rs8025880 chr15:75394881 G/C cg14664628 chr15:75095509 CSK 0.44 6.25 0.32 1.23e-9 Systemic lupus erythematosus; LUSC cis rs9297145 0.958 rs11975761 chr7:98766688 G/A cg05967295 chr7:98741636 SMURF1 -0.94 -15.9 -0.66 8.97e-43 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs1670533 1.000 rs2014318 chr4:1068778 C/T cg27284194 chr4:1044797 NA -0.54 -7.94 -0.4 3.03e-14 Recombination rate (females); LUSC trans rs13390641 0.614 rs67467351 chr2:104084844 C/T cg03260781 chr1:16346299 HSPB7 -0.46 -6.09 -0.32 3.14e-9 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg14440974 chr22:39074834 NA -0.39 -6.44 -0.33 4.23e-10 Menopause (age at onset); LUSC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg15448220 chr1:150897856 SETDB1 0.42 6.13 0.32 2.47e-9 Melanoma; LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC trans rs7937682 0.575 rs7930208 chr11:111741463 T/C cg18187862 chr3:45730750 SACM1L -0.51 -6.17 -0.32 1.99e-9 Primary sclerosing cholangitis; LUSC cis rs68170813 0.605 rs2299428 chr7:107134384 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.51 -0.46 3.85e-19 Coronary artery disease; LUSC cis rs1568889 0.592 rs7110074 chr11:28469325 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.54 6.72 0.35 7.75e-11 Bipolar disorder; LUSC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg00484396 chr16:3507460 NAT15 0.69 12.07 0.55 4.48e-28 Tuberculosis; LUSC cis rs2274273 0.600 rs35112084 chr14:55781100 T/A cg04306507 chr14:55594613 LGALS3 0.48 9.7 0.47 9.23e-20 Protein biomarker; LUSC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.45 -6.23 -0.32 1.42e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg06873352 chr17:61820015 STRADA 0.56 8.62 0.43 2.81e-16 Height; LUSC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.42 -5.89 -0.31 9.49e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg16680214 chr1:154839983 KCNN3 -0.54 -10.28 -0.49 1.05e-21 Prostate cancer; LUSC cis rs4803468 1.000 rs4803463 chr19:41911040 C/G cg09537434 chr19:41945824 ATP5SL -0.89 -15.82 -0.65 1.76e-42 Height; LUSC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg12463550 chr7:65579703 CRCP 0.45 6.65 0.34 1.23e-10 Aortic root size; LUSC trans rs11949289 0.933 rs58515706 chr5:28344653 A/T cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.57e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg20476274 chr7:133979776 SLC35B4 0.86 16.3 0.67 2.31e-44 Mean platelet volume; LUSC cis rs7089973 0.604 rs7914792 chr10:116591391 T/C cg23260525 chr10:116636907 FAM160B1 0.43 9.21 0.45 3.72e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6840360 0.571 rs2165789 chr4:152510130 A/T cg22705602 chr4:152727874 NA -0.32 -6.39 -0.33 5.71e-10 Intelligence (multi-trait analysis); LUSC cis rs9818941 0.910 rs9825122 chr3:157672947 T/C cg08654915 chr3:157813417 NA -0.24 -5.88 -0.31 9.89e-9 Height; LUSC cis rs9457247 0.602 rs2239827 chr6:167490945 G/A cg07741184 chr6:167504864 NA 0.5 8.44 0.42 1.01e-15 Crohn's disease; LUSC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.48 0.59 2.36e-33 Monocyte percentage of white cells; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04520396 chr17:1585312 PRPF8 0.4 6.31 0.33 8.63e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg03517284 chr6:25882590 NA -0.38 -6.8 -0.35 4.95e-11 Height; LUSC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg08677398 chr8:58056175 NA 0.41 5.65 0.3 3.37e-8 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg06877462 chr1:205807181 PM20D1 0.36 5.9 0.31 8.7e-9 Menarche (age at onset); LUSC cis rs7572644 0.639 rs74429612 chr2:27993843 C/T cg27432699 chr2:27873401 GPN1 0.58 7.36 0.37 1.45e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs911119 1.000 rs34374560 chr20:23609462 C/T cg16589663 chr20:23618590 CST3 0.59 6.96 0.36 1.8e-11 Chronic kidney disease; LUSC cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg11266682 chr4:10021025 SLC2A9 0.59 10.67 0.5 4.56e-23 Bone mineral density; LUSC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg04362960 chr10:104952993 NT5C2 0.59 9.31 0.45 1.8e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2708977 0.698 rs772161 chr2:97043803 C/A cg01950434 chr2:97203154 ARID5A -0.45 -5.98 -0.31 5.67e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs34779708 0.966 rs12774834 chr10:35400070 A/T cg04310649 chr10:35416472 CREM -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs877282 0.755 rs11253399 chr10:790030 T/A cg22713356 chr15:30763199 NA 0.91 13.16 0.58 3.71e-32 Uric acid levels; LUSC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg24250549 chr1:154909240 PMVK 0.66 11.05 0.52 2.07e-24 Prostate cancer; LUSC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg27165867 chr14:105738592 BRF1 -0.55 -7.86 -0.39 5.46e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs2905347 0.520 rs1858936 chr7:22647553 G/C cg23521230 chr7:22704884 NA 0.43 5.7 0.3 2.64e-8 Major depression and alcohol dependence; LUSC cis rs4888262 0.545 rs7184754 chr16:74667864 C/T cg01733217 chr16:74700730 RFWD3 0.78 12.75 0.57 1.33e-30 Testicular germ cell tumor; LUSC cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg18681998 chr4:17616180 MED28 0.78 13.71 0.6 3.02e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg22782873 chr19:19639568 YJEFN3 -0.46 -5.82 -0.3 1.39e-8 Bipolar disorder; LUSC cis rs7705502 1.000 rs6861681 chr5:173362458 G/A cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.3e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg18827107 chr12:86230957 RASSF9 -0.5 -7.29 -0.37 2.3e-12 Major depressive disorder; LUSC cis rs9660992 0.700 rs1172125 chr1:205258442 A/T cg00857998 chr1:205179979 DSTYK 0.53 8.12 0.41 9.08e-15 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.43 -6.08 -0.32 3.32e-9 Alzheimer's disease (late onset); LUSC cis rs8068544 0.818 rs8079958 chr17:40155467 C/T cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -1.25 -11.61 -0.54 2.06e-26 Reticulocyte fraction of red cells;Reticulocyte count; LUSC cis rs16854884 0.657 rs4611822 chr3:143735544 C/T cg06585982 chr3:143692056 C3orf58 0.5 8.13 0.41 8.55e-15 Economic and political preferences (feminism/equality); LUSC cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg06784218 chr1:46089804 CCDC17 0.51 10.38 0.49 4.73e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7781370 1.000 rs4727338 chr7:96120675 G/C cg00604640 chr7:96133485 NA -0.33 -5.82 -0.3 1.36e-8 Bone mineral density (hip); LUSC trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg17470723 chr8:74884337 TCEB1 0.51 7.91 0.4 3.71e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7582720 1.000 rs114155121 chr2:203718682 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.42 -0.33 4.69e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18099408 chr3:52552593 STAB1 -0.42 -7.38 -0.37 1.25e-12 Electroencephalogram traits; LUSC cis rs4363385 0.818 rs382292 chr1:153006641 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg22029157 chr1:209979665 IRF6 0.82 10.35 0.49 5.72e-22 Cleft lip with or without cleft palate; LUSC cis rs7112043 1.000 rs7112043 chr11:34789386 A/T cg06937548 chr11:34938143 PDHX;APIP 0.4 5.87 0.31 1.03e-8 Lung disease severity in cystic fibrosis; LUSC trans rs10506458 0.915 rs2013042 chr12:63394211 A/G cg22491629 chr6:157744540 C6orf35 -0.9 -10.88 -0.51 8.12e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2239547 0.603 rs4687698 chr3:53097108 C/T cg25643088 chr3:52874325 TMEM110 0.38 5.86 0.31 1.1e-8 Schizophrenia; LUSC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg07777115 chr5:623756 CEP72 0.45 5.78 0.3 1.75e-8 Obesity-related traits; LUSC trans rs7939886 0.920 rs11227321 chr11:55904828 A/G cg03929089 chr4:120376271 NA 0.77 6.09 0.32 3.03e-9 Myopia (pathological); LUSC cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg26384229 chr12:38710491 ALG10B 0.9 17.22 0.69 5.31e-48 Heart rate; LUSC cis rs7246657 0.943 rs10404920 chr19:37881556 T/C cg23950597 chr19:37808831 NA -0.63 -7.51 -0.38 5.51e-13 Coronary artery calcification; LUSC cis rs453301 0.598 rs10104303 chr8:8834528 A/T cg08975724 chr8:8085496 FLJ10661 0.45 6.6 0.34 1.62e-10 Joint mobility (Beighton score); LUSC cis rs7296418 0.961 rs4148863 chr12:123569375 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -7.1 -0.36 7.69e-12 Platelet count; LUSC cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.83 0.65 1.69e-42 Bladder cancer; LUSC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg03806693 chr22:41940476 POLR3H 0.94 13.78 0.6 1.62e-34 Vitiligo; LUSC cis rs10843647 1.000 rs1114770 chr12:30330231 T/C cg12718339 chr12:29936407 TMTC1 -0.34 -5.77 -0.3 1.77e-8 Glucose homeostasis traits; LUSC cis rs2652834 0.718 rs2729834 chr15:63397047 G/C cg05507819 chr15:63340323 TPM1 0.55 6.98 0.36 1.55e-11 HDL cholesterol; LUSC cis rs6565180 0.962 rs6565183 chr16:30382755 T/C cg17640201 chr16:30407289 ZNF48 -0.9 -16.33 -0.67 1.83e-44 Tonsillectomy; LUSC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.8e-15 Aortic root size; LUSC cis rs12318506 0.623 rs12313311 chr12:75768327 A/T cg04728562 chr12:75699417 CAPS2 -0.82 -5.82 -0.3 1.36e-8 Coronary artery calcification; LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.42 0.38 9.47e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg14534967 chr7:73153139 ABHD11 0.41 5.97 0.31 6.13e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs977987 0.806 rs12051326 chr16:75437887 G/A cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.8e-17 Dupuytren's disease; LUSC trans rs877282 1.000 rs11253370 chr10:773712 G/A cg13042288 chr15:90349979 ANPEP -0.48 -6.93 -0.35 2.24e-11 Uric acid levels; LUSC cis rs868036 0.681 rs2241423 chr15:68086838 G/A cg05925327 chr15:68127851 NA -0.41 -6.6 -0.34 1.6e-10 Restless legs syndrome; LUSC cis rs4423214 0.840 rs1790340 chr11:71182589 T/C cg05163923 chr11:71159392 DHCR7 -0.8 -10.2 -0.49 1.88e-21 Vitamin D levels; LUSC cis rs4132509 0.744 rs12021907 chr1:243995640 A/G cg21452805 chr1:244014465 NA -0.58 -5.96 -0.31 6.25e-9 RR interval (heart rate); LUSC cis rs13401104 0.796 rs10929166 chr2:237111201 C/T cg19324714 chr2:237145437 ASB18 0.43 5.79 0.3 1.6e-8 Educational attainment; LUSC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg09323728 chr8:95962352 TP53INP1 -0.45 -9.42 -0.46 7.83e-19 Type 2 diabetes; LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg25072359 chr17:41440525 NA 0.65 9.08 0.44 9.83e-18 Menopause (age at onset); LUSC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg16132339 chr22:24313637 DDTL;DDT 0.41 6.4 0.33 5.28e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs13233308 0.868 rs1029421 chr7:87418861 T/C cg22633988 chr4:77610603 SHROOM3 -0.43 -6.35 -0.33 7.13e-10 Schizophrenia; LUSC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.46 -6.27 -0.32 1.11e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2952156 1.000 rs2934967 chr17:37870378 G/A cg20243544 chr17:37824526 PNMT 0.48 6.87 0.35 3.2e-11 Asthma; LUSC cis rs6138458 0.701 rs6050255 chr20:25007089 A/G cg26195577 chr20:24973756 C20orf3 0.79 12.11 0.55 3.07e-28 Blood protein levels; LUSC cis rs1009647 1.000 rs1890256 chr14:55881276 C/T cg04306507 chr14:55594613 LGALS3 0.43 7.27 0.37 2.58e-12 Testicular germ cell tumor; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg12419862 chr22:24373484 LOC391322 1.0 19.21 0.72 6.3e-56 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2204008 0.652 rs11520002 chr12:38022179 G/T cg26384229 chr12:38710491 ALG10B 0.93 15.74 0.65 3.8e-42 Bladder cancer; LUSC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.52 0.34 2.54e-10 Schizophrenia; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg09702105 chr4:108910794 HADH 0.38 5.94 0.31 7.04e-9 Mosquito bite size; LUSC cis rs3007168 0.951 rs3007074 chr14:51604731 T/A cg23942311 chr14:51606299 NA 0.37 6.02 0.31 4.5e-9 Cancer; LUSC cis rs11711311 1.000 rs12631232 chr3:113497386 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.55 0.34 2.23e-10 IgG glycosylation; LUSC cis rs6964587 0.839 rs2049314 chr7:91464134 C/T cg17063962 chr7:91808500 NA 0.57 8.62 0.43 2.67e-16 Breast cancer; LUSC cis rs9948 0.655 rs62156212 chr2:97399096 C/T cg01990225 chr2:97406019 LMAN2L -1.03 -7.11 -0.36 7.29e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs2070433 0.904 rs8130209 chr21:47925984 T/C cg12379764 chr21:47803548 PCNT 0.7 9.21 0.45 3.71e-18 Lymphocyte counts; LUSC cis rs877282 1.000 rs12773872 chr10:771939 T/C cg17470449 chr10:769945 NA 0.53 7.31 0.37 1.98e-12 Uric acid levels; LUSC cis rs921968 0.565 rs7594046 chr2:219624170 A/G cg02176678 chr2:219576539 TTLL4 0.58 10.49 0.5 1.91e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs1355223 0.583 rs2956076 chr11:34874124 T/C cg24088639 chr11:34937564 PDHX;APIP -0.47 -6.85 -0.35 3.62e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1577917 1.000 rs1962716 chr6:86648436 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.26 -0.41 3.38e-15 Response to antipsychotic treatment; LUSC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg06544989 chr22:39130855 UNC84B 0.33 5.76 0.3 1.86e-8 Menopause (age at onset); LUSC cis rs11249608 0.548 rs17078988 chr5:178459283 A/G cg21905437 chr5:178450457 ZNF879 0.46 5.98 0.31 5.62e-9 Pubertal anthropometrics; LUSC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.85 0.51 1.06e-23 Monocyte percentage of white cells; LUSC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.16 -0.36 5.25e-12 Blood metabolite levels; LUSC cis rs61931739 0.929 rs7955240 chr12:34066388 G/A cg06521331 chr12:34319734 NA 0.37 6.3 0.33 9.33e-10 Morning vs. evening chronotype; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg06212498 chr3:49045151 WDR6 0.42 7.07 0.36 8.96e-12 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs4845459 0.967 rs6700160 chr1:152593024 A/C cg08895932 chr1:152778580 LCE1C -0.38 -6.46 -0.33 3.68e-10 Psoriasis; LUSC trans rs783147 0.500 rs9456578 chr6:161147368 A/T cg15416064 chr12:49209402 NA -0.43 -6.06 -0.31 3.58e-9 Lp (a) levels; LUSC trans rs1043099 0.912 rs4820831 chr22:30711443 C/T cg10543363 chr10:11784253 ECHDC3 -0.51 -6.06 -0.31 3.73e-9 Rheumatoid arthritis; LUSC trans rs1814175 0.803 rs11040451 chr11:49650639 C/T cg15704280 chr7:45808275 SEPT13 -1.09 -21.84 -0.77 2.65e-66 Height; LUSC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11890956 chr21:40555474 PSMG1 -0.85 -15.07 -0.64 1.55e-39 Cognitive function; LUSC cis rs7511006 1.000 rs7290710 chr22:50677454 C/T cg07895657 chr22:50616420 PANX2 -0.35 -5.79 -0.3 1.58e-8 Obesity-related traits; LUSC cis rs12618769 0.597 rs3769715 chr2:99146855 C/T cg10123293 chr2:99228465 UNC50 0.46 7.47 0.38 7.09e-13 Bipolar disorder; LUSC cis rs73195822 0.614 rs73194056 chr12:111216325 A/G cg12870014 chr12:110450643 ANKRD13A 0.69 7.06 0.36 9.82e-12 Itch intensity from mosquito bite; LUSC cis rs5769707 0.521 rs6009810 chr22:50059540 A/G cg05373962 chr22:49881684 NA -0.4 -8.49 -0.42 7.08e-16 Monocyte count;Monocyte percentage of white cells; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21887597 chr15:83419354 NA 0.53 7.85 0.39 5.76e-14 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11997175 0.595 rs6468204 chr8:33774748 T/C ch.8.33884649F chr8:33765107 NA 0.43 6.31 0.33 8.78e-10 Body mass index; LUSC cis rs290268 0.647 rs1333637 chr9:93557066 C/T cg02608019 chr9:93564028 SYK -0.54 -8.89 -0.44 3.87e-17 Platelet count; LUSC cis rs17270561 0.609 rs9358878 chr6:25740273 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.49 0.38 6.36e-13 Iron status biomarkers; LUSC cis rs62064224 0.589 rs2285428 chr17:30820176 C/T cg18200150 chr17:30822561 MYO1D -0.31 -5.99 -0.31 5.43e-9 Schizophrenia; LUSC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg19539972 chr4:7069911 GRPEL1 -0.65 -7.21 -0.37 3.85e-12 Monocyte percentage of white cells; LUSC cis rs10100465 0.961 rs1508555 chr8:118638344 T/C cg09430518 chr8:118662568 NA -0.29 -5.66 -0.3 3.2e-8 Leprosy; LUSC cis rs1908814 0.516 rs13275143 chr8:11796990 T/A cg00262122 chr8:11665843 FDFT1 0.39 5.7 0.3 2.66e-8 Neuroticism; LUSC cis rs710216 0.957 rs841563 chr1:43429520 C/T cg22176566 chr1:43424700 SLC2A1 0.48 5.98 0.31 5.71e-9 Red cell distribution width; LUSC cis rs11190604 0.767 rs10883483 chr10:102174244 T/C cg07080220 chr10:102295463 HIF1AN 0.59 7.61 0.38 2.86e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4930561 0.690 rs6591334 chr11:67924559 A/G cg04465784 chr11:67976953 SUV420H1 -0.29 -5.73 -0.3 2.19e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg10755058 chr3:40428713 ENTPD3 0.35 5.79 0.3 1.64e-8 Renal cell carcinoma; LUSC cis rs870825 0.616 rs6833858 chr4:185639961 C/T cg04058563 chr4:185651563 MLF1IP 0.82 13.17 0.58 3.35e-32 Blood protein levels; LUSC cis rs3755132 0.929 rs4668950 chr2:15780191 T/C cg12888861 chr2:15731646 DDX1 0.52 7.43 0.38 9.29e-13 Wilms tumor; LUSC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg08493051 chr2:3487164 NA -0.56 -8.81 -0.43 6.76e-17 Neurofibrillary tangles; LUSC cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.32 -0.37 1.84e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21643860 chr11:62358814 TUT1 0.37 6.32 0.33 8.45e-10 Triglycerides; LUSC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg24733560 chr20:60626293 TAF4 0.41 6.73 0.35 7.6e-11 Body mass index; LUSC cis rs4959270 0.869 rs55776749 chr6:452732 A/G cg09757644 chr6:447497 NA 0.28 5.79 0.3 1.66e-8 Limited cutaneous systemic scleroderma; LUSC cis rs1008375 1.000 rs10939744 chr4:17664473 G/T cg16339924 chr4:17578868 LAP3 0.54 7.98 0.4 2.38e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7824557 0.564 rs11782430 chr8:11226071 A/G cg08975724 chr8:8085496 FLJ10661 -0.53 -7.67 -0.39 1.87e-13 Retinal vascular caliber; LUSC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg03060546 chr3:49711283 APEH 0.71 11.99 0.55 8.86e-28 Resting heart rate; LUSC cis rs8141797 0.901 rs4822472 chr22:24468123 C/A cg00411358 chr22:24577142 SUSD2 0.61 6.32 0.33 8.56e-10 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs7903847 0.620 rs17112674 chr10:99122178 C/T cg08345082 chr10:99160200 RRP12 0.34 6.81 0.35 4.68e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs2282300 0.956 rs2685286 chr11:30381588 G/A cg25418670 chr11:30344373 C11orf46 -0.52 -7.25 -0.37 2.91e-12 Morning vs. evening chronotype; LUSC cis rs10089 1.000 rs10478798 chr5:127442394 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 12.06 0.55 4.92e-28 Ileal carcinoids; LUSC trans rs1005277 0.579 rs2474588 chr10:38420870 A/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.77 -0.47 5.22e-20 Extrinsic epigenetic age acceleration; LUSC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg00745463 chr17:30367425 LRRC37B -0.74 -9.02 -0.44 1.49e-17 Hip circumference adjusted for BMI; LUSC cis rs6977940 0.512 rs11765726 chr7:2850878 A/G cg14895029 chr7:2775587 GNA12 0.5 6.35 0.33 7.16e-10 White matter integrity; LUSC cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg26384229 chr12:38710491 ALG10B 0.88 14.49 0.62 2.95e-37 Bladder cancer; LUSC cis rs16866061 1.000 rs12470077 chr2:225334971 T/C cg12698349 chr2:225449008 CUL3 0.84 13.81 0.6 1.21e-34 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs892961 0.932 rs9646396 chr17:75416755 G/A cg05865280 chr17:75406074 SEPT9 0.45 9.24 0.45 3.05e-18 Airflow obstruction; LUSC cis rs2456568 0.508 rs1607403 chr11:93660514 A/G cg26875233 chr11:93583750 C11orf90 -0.31 -6.05 -0.31 3.91e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg24060327 chr5:131705240 SLC22A5 -0.51 -8.44 -0.42 9.59e-16 Breast cancer; LUSC cis rs79387448 0.745 rs7601773 chr2:103120483 G/T cg09003973 chr2:102972529 NA 0.86 8.61 0.43 3.03e-16 Gut microbiota (bacterial taxa); LUSC cis rs1153858 1.000 rs1145081 chr15:45679667 C/G cg21132104 chr15:45694354 SPATA5L1 0.57 8.01 0.4 1.93e-14 Homoarginine levels; LUSC cis rs34375054 0.558 rs67041765 chr12:125672913 T/G cg06287003 chr12:125626642 AACS -0.38 -6.29 -0.33 9.95e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs17270561 0.609 rs9356984 chr6:25725481 C/T cg16482183 chr6:26056742 HIST1H1C -0.62 -8.82 -0.43 6.69e-17 Iron status biomarkers; LUSC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.84 -0.3 1.21e-8 Neutrophil percentage of white cells; LUSC cis rs7474896 0.559 rs1779075 chr10:38167530 C/G cg25427524 chr10:38739819 LOC399744 0.45 5.9 0.31 8.86e-9 Obesity (extreme); LUSC cis rs62400317 0.859 rs6920046 chr6:45159431 A/C cg20913747 chr6:44695427 NA -0.48 -7.7 -0.39 1.56e-13 Total body bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07496106 chr16:46918160 GPT2 0.76 6.09 0.32 3.15e-9 Cognitive performance; LUSC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg14024328 chr4:719362 PCGF3 -0.51 -8.29 -0.41 2.77e-15 White blood cell count; LUSC cis rs7178572 0.524 rs11853287 chr15:77399371 A/G cg22256960 chr15:77711686 NA -0.5 -7.71 -0.39 1.46e-13 Type 2 diabetes; LUSC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg02269571 chr22:50332266 NA -0.6 -9.04 -0.44 1.3e-17 Schizophrenia; LUSC cis rs11190604 1.000 rs7073586 chr10:102307671 A/G cg07080220 chr10:102295463 HIF1AN 0.68 9.55 0.46 2.94e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.16 0.32 2.08e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3126085 0.825 rs10788830 chr1:152206898 A/C cg03465714 chr1:152285911 FLG -0.4 -5.67 -0.3 3.07e-8 Atopic dermatitis; LUSC cis rs763121 0.706 rs3827356 chr22:39064806 G/T cg06544989 chr22:39130855 UNC84B -0.33 -5.84 -0.3 1.21e-8 Menopause (age at onset); LUSC trans rs800082 1.000 rs62275526 chr3:144291707 G/A cg24215973 chr2:240111563 HDAC4 -0.46 -6.93 -0.35 2.19e-11 Smoking behavior; LUSC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg04398451 chr17:18023971 MYO15A -0.47 -7.67 -0.39 1.94e-13 Total body bone mineral density; LUSC cis rs2625529 0.938 rs9120 chr15:72115763 G/A cg16672083 chr15:72433130 SENP8 -0.51 -7.22 -0.37 3.59e-12 Red blood cell count; LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg14844989 chr11:31128820 NA 0.39 5.93 0.31 7.53e-9 Red blood cell count; LUSC cis rs2239547 0.522 rs2581815 chr3:52982159 C/G cg25643088 chr3:52874325 TMEM110 0.39 5.97 0.31 6.09e-9 Schizophrenia; LUSC cis rs7575217 0.767 rs10207371 chr2:101763227 C/T cg23907051 chr2:101730305 TBC1D8 -0.29 -7.68 -0.39 1.76e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs12815613 1.000 rs12815613 chr12:121407256 A/G cg02403541 chr12:121454288 C12orf43 -0.48 -6.04 -0.31 4.06e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg11812906 chr14:75593930 NEK9 0.66 11.38 0.53 1.35e-25 Height; LUSC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg18357526 chr6:26021779 HIST1H4A 0.44 6.97 0.36 1.65e-11 Intelligence (multi-trait analysis); LUSC cis rs6429082 0.715 rs2291687 chr1:235594182 A/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -7.59 -0.38 3.28e-13 Adiposity; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg03579872 chr1:53393473 SCP2 0.38 5.64 0.3 3.54e-8 Monocyte count; LUSC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08704250 chr15:31115839 NA 0.4 6.14 0.32 2.37e-9 Huntington's disease progression; LUSC cis rs7582180 0.652 rs11687864 chr2:100946993 T/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.59 -0.43 3.35e-16 Intelligence (multi-trait analysis); LUSC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg10356904 chr22:49881777 NA -0.33 -7.52 -0.38 5.26e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1577917 0.816 rs9353349 chr6:86707725 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.42 6.11 0.32 2.84e-9 Response to antipsychotic treatment; LUSC cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg17063962 chr7:91808500 NA 0.59 9.35 0.46 1.32e-18 Breast cancer; LUSC cis rs113835537 0.529 rs11227509 chr11:66281194 T/C cg24851651 chr11:66362959 CCS 0.53 7.93 0.4 3.42e-14 Airway imaging phenotypes; LUSC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg15448220 chr1:150897856 SETDB1 0.43 6.29 0.33 1.02e-9 Melanoma; LUSC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg06238570 chr21:40685208 BRWD1 -0.66 -10.47 -0.5 2.29e-22 Cognitive function; LUSC cis rs1040555 0.516 rs242547 chr20:31418581 T/C cg13636640 chr20:31349939 DNMT3B 0.81 14.84 0.63 1.26e-38 Lymphocyte percentage of white cells; LUSC cis rs1160297 0.601 rs1828337 chr2:53096942 G/T cg07782112 chr2:53107842 NA 0.39 6.43 0.33 4.3e-10 Hemostatic factors and hematological phenotypes; LUSC trans rs61931739 0.890 rs1705750 chr12:34142648 C/T cg26384229 chr12:38710491 ALG10B 0.56 9.04 0.44 1.29e-17 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg03676636 chr4:99064102 C4orf37 0.31 6.68 0.34 9.74e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg06671706 chr8:8559999 CLDN23 -0.42 -5.81 -0.3 1.46e-8 Obesity-related traits; LUSC cis rs7851660 0.844 rs4743139 chr9:100638420 A/G cg13688889 chr9:100608707 NA -0.55 -8.34 -0.42 1.91e-15 Strep throat; LUSC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg17376030 chr22:41985996 PMM1 -0.47 -5.73 -0.3 2.19e-8 Vitiligo; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.09 0.4 1.14e-14 Prudent dietary pattern; LUSC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg06494592 chr3:125709126 NA -0.52 -6.01 -0.31 4.85e-9 Blood pressure (smoking interaction); LUSC cis rs4595586 0.566 rs7307174 chr12:39368862 A/G cg26384229 chr12:38710491 ALG10B 0.45 6.3 0.33 9.47e-10 Morning vs. evening chronotype; LUSC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.51 -8.86 -0.44 4.92e-17 Menopause (age at onset); LUSC cis rs11209185 0.563 rs10889733 chr1:68424136 G/A cg22082780 chr1:68452167 NA -0.38 -6.32 -0.33 8.59e-10 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg22800045 chr5:56110881 MAP3K1 0.46 6.5 0.34 2.9e-10 Breast cancer;Breast cancer (early onset); LUSC trans rs34421088 0.560 rs2618434 chr8:11398865 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.47 -0.46 5.22e-19 Neuroticism; LUSC cis rs8062405 1.000 rs62036622 chr16:28837203 T/G cg05966235 chr16:28915196 ATP2A1 0.33 5.81 0.3 1.46e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7833790 0.750 rs10108955 chr8:82690644 C/T cg27398817 chr8:82754497 SNX16 -0.64 -8.01 -0.4 1.9e-14 Diastolic blood pressure; LUSC trans rs6856616 0.614 rs1487630 chr4:38335823 A/G cg06902698 chr1:151137676 SCNM1;LYSMD1 -0.46 -6.77 -0.35 5.65e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs35000415 0.938 rs34725944 chr7:128641653 T/C cg19972273 chr7:128594194 NA 0.68 6.79 0.35 5.04e-11 Systemic lupus erythematosus; LUSC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg18850127 chr7:39170497 POU6F2 0.66 10.7 0.51 3.71e-23 IgG glycosylation; LUSC cis rs28655083 0.529 rs1485794 chr16:77101977 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.39 6.19 0.32 1.72e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.68 -6.43 -0.33 4.4e-10 Cerebrospinal P-tau181p levels; LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg01879757 chr17:41196368 BRCA1 -0.45 -6.83 -0.35 4.07e-11 Menopause (age at onset); LUSC cis rs838147 0.537 rs504963 chr19:49208865 G/A cg21064579 chr19:49206444 FUT2 0.44 8.42 0.42 1.12e-15 Dietary macronutrient intake; LUSC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg07636037 chr3:49044803 WDR6 1.05 18.39 0.71 1.18e-52 Parkinson's disease; LUSC cis rs9527 0.590 rs10509764 chr10:104776475 G/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.15e-10 Arsenic metabolism; LUSC cis rs6005807 0.563 rs7288792 chr22:29015603 C/T cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2860975 1.000 rs10159983 chr10:96774437 C/T cg09036531 chr10:96991505 NA -0.41 -5.66 -0.3 3.26e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg10729496 chr3:10149963 C3orf24 -0.48 -6.68 -0.34 1e-10 Alzheimer's disease; LUSC cis rs28655083 1.000 rs1843457 chr16:77072400 T/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.38 -5.76 -0.3 1.93e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs834603 0.575 rs1799371 chr7:47467436 C/T cg09696706 chr7:47479511 TNS3 0.32 5.87 0.31 1.03e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC trans rs67539049 1.000 rs7832089 chr8:11306003 C/A cg26241650 chr22:40417538 FAM83F 0.45 6.04 0.31 4.03e-9 Itch intensity from mosquito bite; LUSC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg00033643 chr7:134001901 SLC35B4 0.46 7.22 0.37 3.56e-12 Mean platelet volume; LUSC cis rs2235642 0.653 rs7197288 chr16:1654753 C/A cg09025071 chr16:1593152 IFT140;TMEM204 0.3 6.68 0.34 9.74e-11 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14047339 chr6:45345544 RUNX2;SUPT3H 0.4 5.99 0.31 5.54e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19590674 chr17:25783100 NA 0.4 6.2 0.32 1.7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6582630 0.519 rs8186881 chr12:38310285 A/G cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs17092148 1.000 rs6088603 chr20:33370945 A/G cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs1577917 0.958 rs12202712 chr6:86578541 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.22 -0.32 1.45e-9 Response to antipsychotic treatment; LUSC cis rs2404602 0.692 rs35557205 chr15:77130711 T/G cg26408565 chr15:76604113 ETFA -0.5 -7.82 -0.39 6.94e-14 Blood metabolite levels; LUSC cis rs981844 0.689 rs6835372 chr4:154682056 T/C cg14289246 chr4:154710475 SFRP2 -0.5 -7.2 -0.37 3.92e-12 Response to statins (LDL cholesterol change); LUSC cis rs2932538 0.922 rs12750621 chr1:113206502 G/C cg22162597 chr1:113214053 CAPZA1 0.7 9.8 0.47 4.23e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg23172400 chr8:95962367 TP53INP1 0.34 6.82 0.35 4.24e-11 Type 2 diabetes; LUSC cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.78 12.64 0.57 3.42e-30 Colorectal cancer; LUSC cis rs193541 0.632 rs1363200 chr5:122163802 G/T cg19077854 chr5:122220652 SNX24 0.38 7.9 0.4 4.18e-14 Glucose homeostasis traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg27006027 chr19:33165562 ANKRD27;RGS9BP -0.42 -6.13 -0.32 2.42e-9 Electrocardiographic conduction measures; LUSC cis rs6120849 0.663 rs11698868 chr20:33549946 C/T cg24642439 chr20:33292090 TP53INP2 0.62 7.08 0.36 8.79e-12 Protein C levels; LUSC cis rs1595825 0.891 rs2293255 chr2:198621506 T/C cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 5.92e-9 Ulcerative colitis; LUSC cis rs965469 1.000 rs965469 chr20:3381549 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.77 -0.3 1.82e-8 IFN-related cytopenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27261837 chr1:146714163 CHD1L 0.47 7.0 0.36 1.41e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9790314 1.000 rs4370045 chr3:160943865 A/G cg04691961 chr3:161091175 C3orf57 -0.34 -5.87 -0.31 1.02e-8 Morning vs. evening chronotype; LUSC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg01579765 chr21:45077557 HSF2BP -0.52 -11.0 -0.52 3.3e-24 Mean corpuscular volume; LUSC trans rs2679649 1.000 rs2684270 chr6:122352450 C/A cg00167820 chr8:131663355 NA 0.54 6.35 0.33 6.96e-10 Subcutaneous adipose tissue; LUSC cis rs3806843 1.000 rs1030164 chr5:140185272 A/G cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs1003719 0.788 rs8133549 chr21:38447489 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.33 0.53 2.21e-25 Eye color traits; LUSC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18099408 chr3:52552593 STAB1 -0.42 -7.43 -0.38 9.43e-13 Bipolar disorder; LUSC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg20203395 chr5:56204925 C5orf35 -0.56 -8.14 -0.41 7.99e-15 Coronary artery disease; LUSC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg24296786 chr1:45957014 TESK2 0.53 8.36 0.42 1.73e-15 High light scatter reticulocyte count; LUSC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg16928487 chr17:17741425 SREBF1 -0.42 -8.26 -0.41 3.35e-15 Total body bone mineral density; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.49 -8.92 -0.44 3.03e-17 Electroencephalogram traits; LUSC cis rs12594515 1.000 rs8026221 chr15:45987910 G/T cg19682013 chr15:45996608 NA 0.39 6.0 0.31 5.09e-9 Waist circumference;Weight; LUSC cis rs6545883 0.929 rs12617911 chr2:61740825 A/G cg15711740 chr2:61764176 XPO1 -0.5 -7.93 -0.4 3.24e-14 Tuberculosis; LUSC cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -7.63 -0.39 2.54e-13 Schizophrenia; LUSC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg11645453 chr3:52864694 ITIH4 -0.47 -10.43 -0.5 3.06e-22 Schizophrenia; LUSC trans rs61931739 0.500 rs11053213 chr12:34466395 G/T cg26384229 chr12:38710491 ALG10B 0.9 15.73 0.65 4.14e-42 Morning vs. evening chronotype; LUSC trans rs7726839 0.540 rs72705030 chr5:645562 C/T cg25482853 chr8:67687455 SGK3 1.1 15.7 0.65 5.5e-42 Obesity-related traits; LUSC cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg01483505 chr11:975446 AP2A2 0.44 6.1 0.32 2.94e-9 Alzheimer's disease (late onset); LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs10191773 0.589 rs11691239 chr2:112950600 A/C cg07905836 chr2:113190072 RGPD8;RGPD5 -0.7 -7.36 -0.37 1.43e-12 Yeast infection; LUSC cis rs17270561 0.609 rs9358877 chr6:25739228 A/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC cis rs4906332 0.811 rs2021965 chr14:103997248 C/A cg04998671 chr14:104000505 TRMT61A 0.57 7.92 0.4 3.61e-14 Coronary artery disease; LUSC cis rs372883 0.967 rs1153287 chr21:30685611 C/T cg08807101 chr21:30365312 RNF160 -0.4 -5.82 -0.3 1.41e-8 Pancreatic cancer; LUSC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg19920283 chr7:105172520 RINT1 0.59 6.16 0.32 2.14e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2637266 1.000 rs7905033 chr10:78368212 A/C cg18941641 chr10:78392320 NA 0.39 7.06 0.36 9.56e-12 Pulmonary function; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.57 -7.73 -0.39 1.25e-13 Renal function-related traits (BUN); LUSC cis rs7824557 0.767 rs1897950 chr8:11169551 C/A cg27411982 chr8:10470053 RP1L1 0.38 5.89 0.31 9.35e-9 Retinal vascular caliber; LUSC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg26314531 chr2:26401878 FAM59B -0.65 -9.05 -0.44 1.21e-17 Gut microbiome composition (summer); LUSC cis rs478304 0.619 rs10896028 chr11:65432187 A/T cg05805236 chr11:65401703 PCNXL3 -0.65 -10.78 -0.51 1.91e-23 Acne (severe); LUSC trans rs12200782 1.000 rs72845509 chr6:26639865 T/C cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg15383120 chr6:291909 DUSP22 -0.66 -11.04 -0.52 2.32e-24 Menopause (age at onset); LUSC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.15 -0.36 5.59e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2797160 1.000 rs1418948 chr6:126007018 C/T cg05901451 chr6:126070800 HEY2 0.57 8.56 0.42 4.29e-16 Endometrial cancer; LUSC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg11861562 chr11:117069780 TAGLN 0.3 5.76 0.3 1.95e-8 Blood protein levels; LUSC cis rs9517320 1.000 rs9517322 chr13:99126338 C/G cg07423050 chr13:99094983 FARP1 0.33 6.29 0.33 1.02e-9 Longevity; LUSC cis rs12681287 0.547 rs10956873 chr8:87547028 T/C cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs8114671 0.967 rs6142320 chr20:33788193 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -5.93 -0.31 7.56e-9 Height; LUSC cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.56e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg05283184 chr6:79620031 NA 0.58 12.3 0.56 6.3e-29 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg26408565 chr15:76604113 ETFA -0.5 -7.98 -0.4 2.42e-14 Blood metabolite levels; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg14893161 chr1:205819251 PM20D1 1.02 24.42 0.8 2.7e-76 Menarche (age at onset); LUSC cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg18477163 chr1:228402036 OBSCN -0.55 -10.16 -0.49 2.62e-21 Diastolic blood pressure; LUSC cis rs740160 0.510 rs733991 chr7:98895250 C/T cg24650262 chr7:98904301 NA 0.62 6.9 0.35 2.68e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.65 0.57 3.22e-30 Prudent dietary pattern; LUSC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg15445000 chr17:37608096 MED1 0.39 6.72 0.34 8e-11 Lung function (FEV1); LUSC cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.59 -0.43 3.46e-16 Body mass index; LUSC trans rs72674100 1.000 rs9993686 chr4:97974447 C/T cg09670535 chr1:18959427 PAX7 -0.55 -6.26 -0.32 1.18e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg11416102 chr8:651193 ERICH1 0.63 5.83 0.3 1.32e-8 IgG glycosylation; LUSC cis rs877282 0.945 rs71491311 chr10:791747 G/A cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs7759001 0.857 rs4713090 chr6:27350847 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 2.04e-8 Glomerular filtration rate (creatinine); LUSC cis rs2797160 1.000 rs1418639 chr6:125999940 C/T cg05901451 chr6:126070800 HEY2 -0.58 -8.7 -0.43 1.5e-16 Endometrial cancer; LUSC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg21984481 chr17:79567631 NPLOC4 -0.56 -10.83 -0.51 1.23e-23 Eye color traits; LUSC cis rs3771570 0.901 rs3771585 chr2:242400723 G/A cg21155796 chr2:242212141 HDLBP 0.51 6.25 0.32 1.23e-9 Prostate cancer; LUSC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg12463550 chr7:65579703 CRCP -0.48 -7.13 -0.36 6.16e-12 Aortic root size; LUSC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg21699342 chr2:239360505 ASB1 0.43 6.66 0.34 1.14e-10 Multiple system atrophy; LUSC cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg26395211 chr5:140044315 WDR55 0.46 7.11 0.36 6.88e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs73198271 0.740 rs10113326 chr8:8647630 A/T cg01851573 chr8:8652454 MFHAS1 0.53 8.45 0.42 8.97e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17270561 0.609 rs1937132 chr6:25757017 A/G cg17691542 chr6:26056736 HIST1H1C 0.58 7.96 0.4 2.66e-14 Iron status biomarkers; LUSC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg04267008 chr7:1944627 MAD1L1 -0.61 -9.15 -0.45 5.86e-18 Bipolar disorder and schizophrenia; LUSC cis rs7188861 0.681 rs2216763 chr16:11404428 G/A cg00044050 chr16:11439710 C16orf75 0.56 5.94 0.31 7.05e-9 HDL cholesterol; LUSC cis rs11711311 0.712 rs10804510 chr3:113340700 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.94 -0.31 7.34e-9 IgG glycosylation; LUSC cis rs7385804 0.761 rs507392 chr7:100319936 G/A cg20848291 chr7:100343083 ZAN 0.38 5.93 0.31 7.71e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg24562669 chr7:97807699 LMTK2 -0.39 -6.38 -0.33 5.92e-10 Breast cancer; LUSC cis rs7829975 0.742 rs882462 chr8:8678530 G/A cg06636001 chr8:8085503 FLJ10661 0.6 9.09 0.45 8.84e-18 Mood instability; LUSC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.35 -5.65 -0.3 3.45e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg00149659 chr3:10157352 C3orf10 0.97 13.75 0.6 2.17e-34 Alzheimer's disease; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg16145915 chr7:1198662 ZFAND2A -0.75 -16.2 -0.66 5.8e-44 Longevity;Endometriosis; LUSC cis rs12912251 1.000 rs2132157 chr15:38992547 A/G cg01338139 chr15:38987640 C15orf53 -0.49 -6.74 -0.35 6.86e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg00825309 chr19:58991885 ZNF446 -0.5 -7.23 -0.37 3.27e-12 Uric acid clearance; LUSC trans rs1922233 1.000 rs6858278 chr4:92378742 T/G cg24250684 chr1:219729030 NA -0.34 -6.17 -0.32 1.93e-9 Gut microbiome composition (summer and winter); LUSC trans rs1347297 0.526 rs2276617 chr2:179250397 A/G cg14011486 chr1:26737247 LIN28 0.41 6.5 0.34 3e-10 Alzheimer disease and age of onset; LUSC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs10465746 0.780 rs6703493 chr1:84435812 G/A cg10977910 chr1:84465055 TTLL7 0.44 6.43 0.33 4.44e-10 Obesity-related traits; LUSC cis rs2439831 0.850 rs12441127 chr15:44021175 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.87 0.35 3.07e-11 Lung cancer in ever smokers; LUSC cis rs7582180 0.764 rs11691684 chr2:100921776 T/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.56 -0.42 4.2e-16 Intelligence (multi-trait analysis); LUSC cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg02503808 chr4:7069936 GRPEL1 -0.95 -10.96 -0.51 4.39e-24 Monocyte percentage of white cells; LUSC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3755132 1.000 rs56253741 chr2:15730773 A/G cg12888861 chr2:15731646 DDX1 0.5 7.15 0.36 5.5e-12 Wilms tumor; LUSC cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.9 0.4 4.02e-14 Colorectal cancer; LUSC trans rs11165623 0.715 rs1980769 chr1:96888201 A/T cg10631902 chr5:14652156 NA -0.54 -8.76 -0.43 1.03e-16 Hip circumference;Waist circumference; LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg20607798 chr8:58055168 NA 0.57 5.78 0.3 1.7e-8 Developmental language disorder (linguistic errors); LUSC cis rs7481584 0.624 rs516443 chr11:3047294 A/G cg08508325 chr11:3079039 CARS 0.37 8.27 0.41 3.15e-15 Calcium levels; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.33e-19 Menopause (age at onset); LUSC cis rs6693567 0.565 rs1260374 chr1:150331593 G/A cg15654264 chr1:150340011 RPRD2 0.45 7.33 0.37 1.8e-12 Migraine; LUSC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg22467129 chr15:76604101 ETFA -0.43 -6.85 -0.35 3.54e-11 Blood metabolite levels; LUSC cis rs1729951 0.575 rs361237 chr3:136702414 A/G cg21827317 chr3:136751795 NA 0.38 7.02 0.36 1.27e-11 Neuroticism; LUSC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg12463550 chr7:65579703 CRCP 0.63 5.7 0.3 2.7e-8 Diabetic kidney disease; LUSC cis rs2637266 0.783 rs846647 chr10:78515508 C/G cg18941641 chr10:78392320 NA 0.4 7.23 0.37 3.3e-12 Pulmonary function; LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg08219700 chr8:58056026 NA 0.64 8.18 0.41 6.2e-15 Developmental language disorder (linguistic errors); LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg04701473 chr1:161359506 NA 0.41 6.24 0.32 1.35e-9 Educational attainment (years of education); LUSC cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg11657440 chr19:46296263 DMWD -0.64 -9.49 -0.46 4.48e-19 Coronary artery disease; LUSC cis rs1595825 0.891 rs41468149 chr2:198910107 C/G cg10547527 chr2:198650123 BOLL 0.52 6.16 0.32 2.07e-9 Ulcerative colitis; LUSC trans rs9409565 0.762 rs55877910 chr9:97234213 G/C cg05679027 chr9:99775184 HIATL2 -0.5 -7.09 -0.36 8.17e-12 Colorectal cancer (alcohol consumption interaction); LUSC cis rs17125944 0.505 rs17125762 chr14:53289288 A/G cg00686598 chr14:53173677 PSMC6 1.09 9.26 0.45 2.56e-18 Alzheimer's disease (late onset); LUSC cis rs16912285 0.535 rs7109619 chr11:24251339 G/A ch.11.24196551F chr11:24239977 NA 0.89 9.79 0.47 4.54e-20 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7267979 0.586 rs1007708 chr20:25190959 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.66 12.31 0.56 5.81e-29 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.38 -0.33 5.89e-10 Extrinsic epigenetic age acceleration; LUSC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.53e-8 Menopause (age at onset); LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg26314531 chr2:26401878 FAM59B -0.7 -9.75 -0.47 6.29e-20 Gut microbiome composition (summer); LUSC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg18825119 chr6:163149453 PACRG;PARK2 0.33 5.97 0.31 6.08e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11098499 0.909 rs7681214 chr4:120385320 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.05e-9 Corneal astigmatism; LUSC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg11344533 chr11:111475393 SIK2 -0.49 -6.81 -0.35 4.52e-11 Primary sclerosing cholangitis; LUSC cis rs7647973 0.769 rs6446204 chr3:49034879 T/C cg21141812 chr3:48556323 PFKFB4 0.36 6.12 0.32 2.67e-9 Menarche (age at onset); LUSC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg06634786 chr22:41940651 POLR3H -0.57 -6.93 -0.35 2.14e-11 Vitiligo; LUSC cis rs9287719 0.967 rs6733416 chr2:10738684 C/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg13395646 chr4:1353034 KIAA1530 -0.65 -10.68 -0.5 4.28e-23 Longevity; LUSC cis rs9807989 0.507 rs4479442 chr2:103054074 A/T cg03938978 chr2:103052716 IL18RAP 0.37 7.14 0.36 5.95e-12 Asthma; LUSC cis rs12980942 0.872 rs3816052 chr19:41773797 C/T cg25627403 chr19:41769009 HNRNPUL1 0.58 6.28 0.33 1.03e-9 Coronary artery disease; LUSC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.65 -14.7 -0.63 4.64e-38 Hemoglobin concentration; LUSC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg01570182 chr17:44337453 NA -0.67 -10.11 -0.48 3.77e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs208520 0.526 rs9351542 chr6:66788571 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.23 -25.77 -0.82 2.2e-81 Exhaled nitric oxide output; LUSC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg25019033 chr10:957182 NA -0.52 -7.06 -0.36 9.93e-12 Eosinophil percentage of granulocytes; LUSC cis rs708547 0.874 rs1401190 chr4:57885174 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.55 -0.34 2.14e-10 Response to bleomycin (chromatid breaks); LUSC cis rs28785552 0.589 rs7257371 chr19:53243910 A/G cg22067481 chr19:53234126 ZNF611 -0.5 -6.63 -0.34 1.34e-10 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs2262909 0.962 rs409835 chr19:22230671 T/C cg11619707 chr19:22235551 ZNF257 -0.38 -5.7 -0.3 2.7e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg03146154 chr1:46216737 IPP 0.51 7.65 0.39 2.12e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg16515820 chr3:114866447 ZBTB20 0.48 6.62 0.34 1.44e-10 Cognitive function;Information processing speed; LUSC cis rs1577917 0.917 rs2084293 chr6:86566002 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg21132104 chr15:45694354 SPATA5L1 0.57 8.14 0.41 7.67e-15 Homoarginine levels; LUSC trans rs4596713 0.603 rs9314854 chr9:71686181 T/C cg04349162 chr17:62464701 C17orf60 -0.35 -6.05 -0.31 3.92e-9 Headache; LUSC cis rs1044826 0.642 rs6784684 chr3:139177634 T/C cg00490450 chr3:139108681 COPB2 0.45 7.05 0.36 1.05e-11 Obesity-related traits; LUSC cis rs9325144 0.600 rs6582634 chr12:38748041 G/A cg26384229 chr12:38710491 ALG10B 0.61 9.49 0.46 4.41e-19 Morning vs. evening chronotype; LUSC cis rs7607369 0.536 rs7566656 chr2:219664519 A/G cg02176678 chr2:219576539 TTLL4 -0.51 -9.02 -0.44 1.53e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs9329221 0.905 rs17709397 chr8:10249861 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -8.26 -0.41 3.39e-15 Neuroticism; LUSC cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg08999081 chr20:33150536 PIGU 0.48 9.78 0.47 4.88e-20 Glomerular filtration rate (creatinine); LUSC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg03354898 chr7:1950403 MAD1L1 0.32 6.35 0.33 6.93e-10 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg16325326 chr1:53192061 ZYG11B -1.0 -20.14 -0.74 1.24e-59 Monocyte count; LUSC cis rs722599 0.748 rs731952 chr14:75366447 A/G cg06637938 chr14:75390232 RPS6KL1 0.41 6.02 0.31 4.66e-9 IgG glycosylation; LUSC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.15 -0.32 2.16e-9 Major depressive disorder; LUSC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs8014204 0.935 rs2300596 chr14:75353855 C/T cg08847533 chr14:75593920 NEK9 0.39 5.77 0.3 1.81e-8 Caffeine consumption; LUSC cis rs1395 1.000 rs1395 chr2:27424636 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.38 -6.23 -0.32 1.4e-9 Blood metabolite levels; LUSC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg23583168 chr7:148888333 NA -0.84 -14.83 -0.63 1.35e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12541635 0.801 rs12155862 chr8:107105243 G/A cg10147462 chr8:107024639 NA -0.45 -7.99 -0.4 2.18e-14 Age of smoking initiation; LUSC cis rs11098499 0.863 rs3822191 chr4:120428101 A/T cg09307838 chr4:120376055 NA 0.75 10.72 0.51 3.04e-23 Corneal astigmatism; LUSC cis rs911119 0.913 rs13037490 chr20:23583725 T/C cg16589663 chr20:23618590 CST3 0.65 7.8 0.39 8.05e-14 Chronic kidney disease; LUSC cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg07828340 chr4:882639 GAK 1.1 11.94 0.55 1.33e-27 Intelligence (multi-trait analysis); LUSC cis rs8072100 0.544 rs7214993 chr17:45386797 C/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.35 -5.98 -0.31 5.87e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7903847 0.642 rs12258560 chr10:99137048 T/C cg08345082 chr10:99160200 RRP12 -0.38 -7.68 -0.39 1.72e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs9354308 0.933 rs10455586 chr6:66571498 T/C cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg09877947 chr5:131593287 PDLIM4 -0.37 -5.89 -0.31 9.18e-9 Breast cancer;Mosquito bite size; LUSC cis rs7582180 0.663 rs2053263 chr2:100971407 A/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.42 -0.42 1.15e-15 Intelligence (multi-trait analysis); LUSC cis rs868036 0.681 rs13329567 chr15:68104367 C/T cg24579218 chr15:68104479 NA -0.39 -6.81 -0.35 4.68e-11 Restless legs syndrome; LUSC cis rs7789940 1.000 rs2072435 chr7:75959188 G/A cg15798862 chr7:76129360 DTX2 -0.51 -8.57 -0.42 3.77e-16 Multiple sclerosis; LUSC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg16624210 chr5:671434 TPPP 0.5 6.47 0.33 3.58e-10 Obesity-related traits; LUSC cis rs11676348 0.808 rs4674267 chr2:219046437 C/T cg06547715 chr2:218990976 CXCR2 0.31 5.87 0.31 1.07e-8 Ulcerative colitis; LUSC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3771570 1.000 rs62193197 chr2:242294301 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.76 0.35 6.25e-11 Prostate cancer; LUSC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg17971929 chr21:40555470 PSMG1 0.48 7.37 0.37 1.37e-12 Cognitive function; LUSC cis rs6845621 0.745 rs1517989 chr4:18854961 T/C cg12196642 chr4:18937545 NA -0.31 -5.84 -0.3 1.23e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7212590 0.748 rs8074843 chr17:57935935 C/G cg10252138 chr17:58120427 NA -0.73 -7.06 -0.36 9.79e-12 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC trans rs2204008 0.715 rs3899385 chr12:38169880 C/G cg06521331 chr12:34319734 NA -0.39 -6.12 -0.32 2.68e-9 Bladder cancer; LUSC cis rs73200209 0.704 rs17498131 chr12:116436185 C/G cg01776926 chr12:116560359 MED13L -0.51 -6.01 -0.31 4.9e-9 Total body bone mineral density; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg14004847 chr7:1930337 MAD1L1 -0.57 -8.78 -0.43 8.63e-17 Bipolar disorder and schizophrenia; LUSC cis rs2012796 0.785 rs61986597 chr14:81853107 T/C cg02996355 chr14:81879375 NA 0.56 8.04 0.4 1.62e-14 Night sleep phenotypes; LUSC cis rs2625529 0.504 rs11072349 chr15:72464471 T/C cg16672083 chr15:72433130 SENP8 0.48 7.88 0.4 4.61e-14 Red blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02806352 chr6:36410757 PXT1;KCTD20 0.49 7.18 0.37 4.64e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg10729496 chr3:10149963 C3orf24 0.54 7.18 0.37 4.45e-12 Alzheimer's disease; LUSC cis rs6500602 0.653 rs4786487 chr16:4440397 C/G cg08645402 chr16:4508243 NA -0.42 -6.43 -0.33 4.4e-10 Schizophrenia; LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg18099408 chr3:52552593 STAB1 -0.43 -7.65 -0.39 2.16e-13 Bipolar disorder; LUSC cis rs12711979 0.509 rs10192699 chr2:3824297 A/G cg17052675 chr2:3827356 NA -0.83 -20.1 -0.74 1.83e-59 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs672059 0.966 rs492228 chr1:183156476 T/C ch.1.3577855R chr1:183094577 LAMC1 0.54 7.99 0.4 2.15e-14 Hypertriglyceridemia; LUSC trans rs12165098 0.636 rs11873983 chr18:36748849 A/G cg23858286 chr9:138135095 NA -0.42 -6.18 -0.32 1.84e-9 Sleep duration; LUSC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.93 0.35 2.24e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1003719 0.680 rs2835668 chr21:38580151 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.18 -0.49 2.18e-21 Eye color traits; LUSC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.06e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01859739 chr19:58739986 ZNF544 -0.41 -6.06 -0.31 3.61e-9 Electrocardiographic conduction measures; LUSC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg25767906 chr1:53392781 SCP2 0.46 8.16 0.41 7.03e-15 Monocyte count; LUSC cis rs9814567 0.964 rs9820150 chr3:134223011 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.69 -0.6 3.65e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3820068 0.608 rs10927840 chr1:16045250 A/G cg13390004 chr1:15929781 NA 0.41 6.51 0.34 2.71e-10 Systolic blood pressure; LUSC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg03806693 chr22:41940476 POLR3H -0.96 -13.54 -0.6 1.34e-33 Vitiligo; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg07362569 chr17:61921086 SMARCD2 0.38 7.76 0.39 1.01e-13 Prudent dietary pattern; LUSC trans rs804280 0.509 rs35626932 chr8:11786932 C/A cg14343924 chr8:8086146 FLJ10661 0.47 6.55 0.34 2.18e-10 Myopia (pathological); LUSC cis rs11864453 0.612 rs12924413 chr16:72129745 T/C cg16558253 chr16:72132732 DHX38 -0.38 -6.07 -0.32 3.45e-9 Fibrinogen levels; LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg25767906 chr1:53392781 SCP2 0.48 8.63 0.43 2.55e-16 Monocyte count; LUSC cis rs9467711 0.606 rs9358937 chr6:26374274 C/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.02 -0.36 1.25e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.37 0.33 6.13e-10 Hip circumference adjusted for BMI; LUSC cis rs72781680 0.846 rs55707417 chr2:24029928 G/A cg20701182 chr2:24300061 SF3B14 0.73 7.4 0.38 1.12e-12 Lymphocyte counts; LUSC trans rs11696501 0.739 rs6104252 chr20:44254323 G/A cg03272292 chr12:48577362 C12orf68 0.49 5.99 0.31 5.29e-9 Brain structure; LUSC trans rs1864729 0.748 rs2635165 chr8:98296209 T/C cg08679828 chr8:102218111 ZNF706 -0.71 -6.28 -0.32 1.04e-9 Estradiol plasma levels (breast cancer); LUSC cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs4253772 0.938 rs10154348 chr22:46638159 C/A cg24881330 chr22:46731750 TRMU 0.63 5.85 0.31 1.15e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg06784218 chr1:46089804 CCDC17 -0.55 -11.21 -0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1486139 1.000 rs1385934 chr7:46268072 A/C cg17534202 chr9:96721102 NA -0.35 -6.15 -0.32 2.26e-9 Select biomarker traits; LUSC cis rs500891 0.525 rs35281711 chr6:84093177 G/A cg08257003 chr6:84140564 ME1 0.32 7.29 0.37 2.29e-12 Platelet-derived growth factor BB levels; LUSC trans rs9929218 0.817 rs3114400 chr16:68719430 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.89 -13.91 -0.61 5.27e-35 Colorectal cancer; LUSC cis rs921665 0.831 rs4497900 chr2:3190754 A/G cg02624386 chr2:3182749 NA 0.59 6.58 0.34 1.8e-10 World class endurance athleticism; LUSC cis rs3770081 1.000 rs3770082 chr2:86280922 T/G cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg07395648 chr5:131743802 NA -0.46 -7.23 -0.37 3.33e-12 Breast cancer;Mosquito bite size; LUSC cis rs68170813 0.521 rs75035695 chr7:106818731 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.38e-20 Coronary artery disease; LUSC cis rs9487051 0.703 rs351755 chr6:109538073 G/A cg12927641 chr6:109611667 NA 0.35 5.79 0.3 1.61e-8 Reticulocyte fraction of red cells; LUSC trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg03929089 chr4:120376271 NA 0.6 6.43 0.33 4.33e-10 Axial length; LUSC cis rs73198271 0.515 rs78890841 chr8:8637018 G/A cg01851573 chr8:8652454 MFHAS1 0.56 6.24 0.32 1.32e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4280164 0.945 rs4374085 chr14:24771080 T/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.57 -6.75 -0.35 6.52e-11 Parent of origin effect on language impairment (paternal); LUSC cis rs7527798 0.592 rs12022909 chr1:207859743 T/C cg09232269 chr1:207846808 CR1L -0.3 -6.33 -0.33 7.79e-10 Erythrocyte sedimentation rate; LUSC trans rs979233 0.502 rs276241 chr5:42060180 T/C cg07010552 chr17:7358735 CHRNB1 -0.42 -6.06 -0.31 3.71e-9 Systemic lupus erythematosus; LUSC cis rs7827545 0.545 rs6988000 chr8:135559534 C/T cg17885191 chr8:135476712 NA 0.64 8.38 0.42 1.45e-15 Hypertension (SNP x SNP interaction); LUSC cis rs6693567 0.565 rs1694379 chr1:150292417 C/A cg09579323 chr1:150459698 TARS2 0.4 5.66 0.3 3.27e-8 Migraine; LUSC cis rs2245008 0.774 rs253136 chr16:83979601 A/C cg27171569 chr16:83987465 OSGIN1 -0.54 -9.61 -0.47 1.8e-19 Pursuit maintenance gain; LUSC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg18876405 chr7:65276391 NA 0.55 8.79 0.43 8.1e-17 Aortic root size; LUSC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg12516959 chr21:47718080 NA -0.48 -7.48 -0.38 6.78e-13 Testicular germ cell tumor; LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg08677398 chr8:58056175 NA 0.54 6.39 0.33 5.43e-10 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg12463550 chr7:65579703 CRCP 0.53 7.73 0.39 1.29e-13 Aortic root size; LUSC trans rs8073060 0.614 rs225279 chr17:33974214 A/G cg19694781 chr19:47549865 TMEM160 -1.14 -17.81 -0.7 2.27e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs7615952 1.000 rs9289275 chr3:125648659 A/T cg07211511 chr3:129823064 LOC729375 -1.26 -21.01 -0.75 4.84e-63 Blood pressure (smoking interaction); LUSC cis rs9300255 0.568 rs1790108 chr12:123636841 A/G cg05973401 chr12:123451056 ABCB9 0.54 6.67 0.34 1.06e-10 Neutrophil percentage of white cells; LUSC cis rs8017423 0.569 rs10141476 chr14:90823351 C/T cg04374321 chr14:90722782 PSMC1 -0.42 -6.39 -0.33 5.65e-10 Mortality in heart failure; LUSC cis rs7107174 1.000 rs948662 chr11:77979829 A/G cg02023728 chr11:77925099 USP35 0.46 6.65 0.34 1.23e-10 Testicular germ cell tumor; LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg08280861 chr8:58055591 NA 0.53 5.83 0.3 1.31e-8 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.28 0.53 3.33e-25 Menopause (age at onset); LUSC trans rs8073060 0.544 rs225287 chr17:33929487 G/T cg19694781 chr19:47549865 TMEM160 -1.12 -17.8 -0.7 2.55e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg04827223 chr11:72435913 ARAP1 -0.75 -13.06 -0.58 8.57e-32 Body mass index; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg14159672 chr1:205819179 PM20D1 0.86 15.4 0.64 8.29e-41 Menarche (age at onset); LUSC cis rs17756712 0.527 rs1193742 chr6:635629 T/C cg14374089 chr6:596013 EXOC2 0.51 7.21 0.37 3.8e-12 Vertical cup-disc ratio; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20994084 chr17:79269488 SLC38A10 0.37 6.19 0.32 1.75e-9 Triglycerides; LUSC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg26677194 chr12:130822605 PIWIL1 0.59 8.73 0.43 1.22e-16 Menopause (age at onset); LUSC trans rs4689592 0.513 rs3857178 chr4:7066516 G/A cg07817883 chr1:32538562 TMEM39B -0.61 -7.45 -0.38 7.97e-13 Monocyte percentage of white cells; LUSC cis rs6489882 0.867 rs7132404 chr12:113368605 A/G cg20102336 chr12:113376681 OAS3 -0.42 -6.13 -0.32 2.44e-9 Chronic lymphocytic leukemia; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg01802117 chr1:53393560 SCP2 -0.39 -6.67 -0.34 1.05e-10 Monocyte count; LUSC trans rs9329221 0.527 rs4841351 chr8:10327367 G/A cg15556689 chr8:8085844 FLJ10661 -0.49 -6.97 -0.36 1.73e-11 Neuroticism; LUSC cis rs7618501 1.000 rs7618519 chr3:49772708 A/T cg24110177 chr3:50126178 RBM5 0.42 6.73 0.35 7.18e-11 Intelligence (multi-trait analysis); LUSC cis rs854765 0.693 rs8080061 chr17:17776389 C/T cg16928487 chr17:17741425 SREBF1 0.46 9.01 0.44 1.59e-17 Total body bone mineral density; LUSC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.05 -0.36 1.02e-11 Colorectal cancer; LUSC cis rs16976116 0.855 rs28649719 chr15:55500211 C/T cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg21963583 chr11:68658836 MRPL21 0.56 8.32 0.41 2.29e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs17490626 0.568 rs2033371 chr10:71212310 G/A cg12610070 chr10:71211762 TSPAN15 -0.48 -9.25 -0.45 2.74e-18 Thrombosis; LUSC cis rs6546886 0.912 rs4853006 chr2:74263419 A/G cg14702570 chr2:74259524 NA -0.31 -5.78 -0.3 1.67e-8 Dialysis-related mortality; LUSC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg18402987 chr7:1209562 NA 0.69 8.0 0.4 2.02e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg06634786 chr22:41940651 POLR3H -0.48 -5.65 -0.3 3.4e-8 Vitiligo; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.68 0.39 1.74e-13 Prudent dietary pattern; LUSC cis rs17401966 0.540 rs3748581 chr1:10441664 T/C cg19773385 chr1:10388646 KIF1B -0.37 -6.49 -0.33 3.08e-10 Hepatocellular carcinoma; LUSC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg00933542 chr6:150070202 PCMT1 0.31 6.48 0.33 3.33e-10 Lung cancer; LUSC cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg05283184 chr6:79620031 NA -0.57 -12.03 -0.55 6.25e-28 Intelligence (multi-trait analysis); LUSC cis rs6840360 0.593 rs6855883 chr4:152688997 A/G cg22705602 chr4:152727874 NA -0.34 -7.57 -0.38 3.77e-13 Intelligence (multi-trait analysis); LUSC cis rs9879311 0.643 rs1473183 chr3:10411827 C/T cg11030744 chr3:10328490 GHRL;GHRLOS 0.45 7.08 0.36 8.56e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.2 -0.32 1.71e-9 Coronary artery disease; LUSC trans rs1728785 1.000 rs1170429 chr16:68604126 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs4595586 0.545 rs11615638 chr12:39364766 A/C cg26384229 chr12:38710491 ALG10B 0.5 7.17 0.37 4.71e-12 Morning vs. evening chronotype; LUSC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg20887711 chr4:1340912 KIAA1530 0.55 8.59 0.43 3.43e-16 Longevity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00330502 chr2:219264282 CTDSP1 -0.41 -6.01 -0.31 4.89e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18404041 chr3:52824283 ITIH1 -0.44 -7.9 -0.4 3.99e-14 Electroencephalogram traits; LUSC cis rs11122272 0.701 rs2883799 chr1:231531166 C/G cg06096015 chr1:231504339 EGLN1 0.58 10.45 0.5 2.68e-22 Hemoglobin concentration; LUSC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg11663144 chr21:46675770 NA -0.41 -7.1 -0.36 7.43e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs714027 1.000 rs2412973 chr22:30529631 C/A cg11564601 chr22:30592435 NA -0.37 -6.82 -0.35 4.38e-11 Lymphocyte counts; LUSC trans rs11148252 0.514 rs2296347 chr13:52728423 A/C cg18335740 chr13:41363409 SLC25A15 -0.47 -6.92 -0.35 2.28e-11 Lewy body disease; LUSC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg10556349 chr10:835070 NA 0.55 6.21 0.32 1.53e-9 Eosinophil percentage of granulocytes; LUSC cis rs35264875 0.846 rs72930627 chr11:68867121 C/A cg02660097 chr11:68866761 NA 0.42 5.78 0.3 1.68e-8 Blond vs. brown hair color; LUSC cis rs7909074 0.898 rs10793565 chr10:45388231 G/C cg05187965 chr10:45406764 TMEM72 -0.38 -9.04 -0.44 1.3e-17 Mean corpuscular volume; LUSC cis rs9473147 0.516 rs2151974 chr6:47515630 G/A cg12968598 chr6:47444699 CD2AP 0.52 7.94 0.4 3.18e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs1003719 0.788 rs9977314 chr21:38471963 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.24 0.52 4.48e-25 Eye color traits; LUSC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg01475377 chr6:109611718 NA -0.46 -8.44 -0.42 1e-15 Reticulocyte fraction of red cells; LUSC trans rs7951105 1.000 rs7932010 chr11:39243705 C/G cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs1153858 0.945 rs16943246 chr15:45720597 G/A cg14582100 chr15:45693742 SPATA5L1 0.57 9.69 0.47 9.56e-20 Homoarginine levels; LUSC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6835098 1.000 rs4695826 chr4:174089426 T/G cg08422745 chr4:174089978 GALNT7 -0.82 -13.52 -0.59 1.67e-33 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs4789693 0.546 rs7220204 chr17:80376130 T/A cg04308225 chr17:80449738 NA 0.39 6.12 0.32 2.6e-9 Glucocorticoid-induced osteonecrosis; LUSC cis rs7043114 0.525 rs1133908 chr9:95068046 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.46 -0.33 3.63e-10 Height; LUSC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg20701182 chr2:24300061 SF3B14 0.9 11.53 0.53 4.11e-26 Lymphocyte counts; LUSC cis rs4969178 0.965 rs938351 chr17:76399404 C/T cg20026190 chr17:76395443 PGS1 0.45 8.01 0.4 1.93e-14 HDL cholesterol levels; LUSC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg13918804 chr1:2043761 PRKCZ 0.27 5.8 0.3 1.58e-8 Height; LUSC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg08048268 chr3:133502702 NA -0.51 -9.84 -0.47 3.14e-20 Iron status biomarkers; LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg10802521 chr3:52805072 NEK4 0.5 7.74 0.39 1.2e-13 Bipolar disorder; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg07157834 chr1:205819609 PM20D1 0.75 12.54 0.57 8.23e-30 Menarche (age at onset); LUSC cis rs4474465 1.000 rs7106080 chr11:78150592 G/A cg27205649 chr11:78285834 NARS2 -0.51 -6.02 -0.31 4.71e-9 Alzheimer's disease (survival time); LUSC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg02896835 chr1:92012615 NA -0.65 -11.81 -0.54 4.04e-27 Breast cancer; LUSC cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg16482183 chr6:26056742 HIST1H1C 0.65 9.2 0.45 4.03e-18 Iron status biomarkers; LUSC trans rs8072100 0.790 rs34200664 chr17:45744652 C/T cg04995722 chr7:26192034 NFE2L3 0.42 6.62 0.34 1.44e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7264396 0.563 rs6060592 chr20:34352414 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -7.5 -0.38 5.67e-13 Total cholesterol levels; LUSC cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg18132916 chr6:79620363 NA -0.42 -6.57 -0.34 1.93e-10 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg02569458 chr12:86230093 RASSF9 0.54 8.82 0.43 6.7e-17 Major depressive disorder; LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg08027265 chr7:2291960 NA -0.38 -6.22 -0.32 1.52e-9 Bipolar disorder and schizophrenia; LUSC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg05805236 chr11:65401703 PCNXL3 0.36 5.84 0.3 1.23e-8 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs4076764 0.801 rs6698738 chr1:163359918 G/A cg06092702 chr1:163392909 NA -0.39 -6.43 -0.33 4.5e-10 Motion sickness; LUSC cis rs5758659 0.935 rs134879 chr22:42664201 A/C cg15557168 chr22:42548783 NA -0.43 -7.25 -0.37 2.98e-12 Cognitive function; LUSC cis rs6121246 0.522 rs6088736 chr20:30195166 C/G cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.26 0.32 1.18e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1153858 0.621 rs2687512 chr15:45581495 T/C cg26924012 chr15:45694286 SPATA5L1 -1.07 -16.89 -0.68 1.06e-46 Homoarginine levels; LUSC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg06454157 chr6:167490870 NA -0.26 -6.08 -0.32 3.25e-9 Crohn's disease; LUSC cis rs10193935 0.901 rs62142639 chr2:42600019 C/G cg27598129 chr2:42591480 NA -0.65 -8.7 -0.43 1.5e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg17971929 chr21:40555470 PSMG1 -0.61 -9.82 -0.47 3.79e-20 Cognitive function; LUSC trans rs208520 0.874 rs208473 chr6:66917265 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -14.1 -0.61 9.35e-36 Exhaled nitric oxide output; LUSC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg22442454 chr1:209979470 IRF6 0.43 5.89 0.31 9.29e-9 Cleft lip with or without cleft palate; LUSC cis rs4363385 0.747 rs1413848 chr1:152970210 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.79 -0.39 8.81e-14 Inflammatory skin disease; LUSC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Tonsillectomy; LUSC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs7582180 0.903 rs2309819 chr2:100899665 C/T cg08017756 chr2:100939284 LONRF2 -0.35 -5.92 -0.31 7.88e-9 Intelligence (multi-trait analysis); LUSC trans rs13011075 0.919 rs2902068 chr2:68614918 T/G cg14221825 chr19:46271408 SIX5 0.43 6.22 0.32 1.51e-9 Mean corpuscular volume; LUSC cis rs757110 0.590 rs7484027 chr11:17368381 T/A cg15432903 chr11:17409602 KCNJ11 -0.44 -7.82 -0.39 6.99e-14 Type 2 diabetes; LUSC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg06238570 chr21:40685208 BRWD1 -0.57 -8.96 -0.44 2.41e-17 Menarche (age at onset); LUSC cis rs1322512 0.792 rs2623952 chr6:152965132 A/G cg27316956 chr6:152958899 SYNE1 -0.37 -6.32 -0.33 8.6e-10 Tonometry; LUSC cis rs1979679 0.659 rs11049461 chr12:28360621 C/A cg13890972 chr12:28721907 NA 0.45 6.18 0.32 1.91e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg03929089 chr4:120376271 NA -0.98 -16.38 -0.67 1.14e-44 Coronary artery disease; LUSC cis rs2239815 0.515 rs5752810 chr22:29225523 G/A cg02153584 chr22:29168773 CCDC117 0.52 6.22 0.32 1.48e-9 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg19318889 chr4:1322082 MAEA 0.78 14.67 0.63 6.05e-38 Longevity; LUSC cis rs7945718 0.967 rs11022496 chr11:12789561 G/A cg25843174 chr11:12811716 TEAD1 0.31 7.03 0.36 1.16e-11 Educational attainment (years of education); LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -5.75 -0.3 1.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs7618501 1.000 rs11130221 chr3:49819102 C/G cg24110177 chr3:50126178 RBM5 -0.42 -6.6 -0.34 1.63e-10 Intelligence (multi-trait analysis); LUSC cis rs6733011 0.628 rs4263159 chr2:99456151 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.61 -0.34 1.53e-10 Bipolar disorder; LUSC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.46 -0.38 7.78e-13 Aortic root size; LUSC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg02574844 chr11:5959923 NA -0.41 -6.4 -0.33 5.33e-10 DNA methylation (variation); LUSC cis rs56283067 0.847 rs10807302 chr6:44710152 G/C cg18551225 chr6:44695536 NA -0.49 -8.39 -0.42 1.41e-15 Total body bone mineral density; LUSC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg08847533 chr14:75593920 NEK9 0.84 15.57 0.65 1.85e-41 Height; LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs4242434 0.927 rs3735894 chr8:22454826 A/G cg03733263 chr8:22462867 KIAA1967 1.02 18.33 0.71 1.97e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs116988415 0.584 rs2269306 chr14:65245417 A/G cg00114569 chr14:65239327 SPTB -0.59 -6.41 -0.33 5.08e-10 Daytime sleep phenotypes; LUSC trans rs61931739 0.500 rs10844845 chr12:34381117 C/T cg26384229 chr12:38710491 ALG10B 0.78 13.36 0.59 6.3e-33 Morning vs. evening chronotype; LUSC cis rs62408225 0.962 rs58521088 chr6:90985198 A/T cg06866423 chr6:90926672 BACH2 0.41 5.87 0.31 1.03e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8060686 0.641 rs7204974 chr16:68033539 G/A cg26727032 chr16:67993705 SLC12A4 -0.43 -6.14 -0.32 2.31e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs11098499 0.909 rs7681978 chr4:120383775 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.14e-9 Corneal astigmatism; LUSC trans rs1459104 0.714 rs67321261 chr11:54911368 A/G cg03929089 chr4:120376271 NA 0.74 6.24 0.32 1.36e-9 Body mass index; LUSC trans rs961253 0.556 rs6038442 chr20:6325523 G/T cg21095983 chr6:86352623 SYNCRIP 0.45 6.78 0.35 5.62e-11 Colorectal cancer; LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg18404041 chr3:52824283 ITIH1 -0.58 -11.03 -0.52 2.51e-24 Bipolar disorder; LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg01616529 chr11:638424 DRD4 -0.37 -6.08 -0.32 3.22e-9 Systemic lupus erythematosus; LUSC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.59 -0.38 3.27e-13 Developmental language disorder (linguistic errors); LUSC cis rs3806843 0.551 rs184996 chr5:140323773 T/A cg19875535 chr5:140030758 IK 0.37 5.66 0.3 3.3e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs10089 1.000 rs3805612 chr5:127505316 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.62 0.54 1.97e-26 Ileal carcinoids; LUSC cis rs7615316 0.934 rs6792259 chr3:142301439 A/T cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.58e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs1555543 0.517 rs2391766 chr1:96909240 T/C cg10631902 chr5:14652156 NA -0.49 -6.74 -0.35 6.84e-11 Body mass index; LUSC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs61990749 0.597 rs1477260 chr14:78256818 G/C cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.3 0.33 9.38e-10 Fibroblast growth factor basic levels; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.47 0.33 3.44e-10 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02865447 chr6:90062469 UBE2J1 -0.44 -6.68 -0.34 1.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17253792 0.822 rs17747083 chr14:56110594 T/C cg01858014 chr14:56050164 KTN1 -0.84 -6.78 -0.35 5.6e-11 Putamen volume; LUSC cis rs9300255 0.602 rs1051431 chr12:123645803 G/A cg05973401 chr12:123451056 ABCB9 0.54 6.64 0.34 1.24e-10 Neutrophil percentage of white cells; LUSC cis rs7909074 0.831 rs2065466 chr10:45384047 T/C cg05187965 chr10:45406764 TMEM72 -0.36 -8.38 -0.42 1.49e-15 Mean corpuscular volume; LUSC trans rs11098499 0.954 rs6846442 chr4:120326323 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs9814567 1.000 rs6769885 chr3:134286913 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.01 -0.61 2.13e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2180341 0.618 rs12199451 chr6:127597780 C/G cg27446573 chr6:127587934 RNF146 0.61 9.71 0.47 8.39e-20 Breast cancer; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.81 -0.35 4.6e-11 Menopause (age at onset); LUSC cis rs7216064 1.000 rs2052187 chr17:65834737 T/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.57 -0.46 2.47e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6496667 0.683 rs1869180 chr15:90895467 T/C cg10434728 chr15:90938212 IQGAP1 0.35 6.53 0.34 2.39e-10 Rheumatoid arthritis; LUSC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4776059 0.550 rs8030871 chr15:52938101 G/A cg22715398 chr15:52968154 KIAA1370 -0.61 -6.81 -0.35 4.44e-11 Schizophrenia; LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg14004847 chr7:1930337 MAD1L1 -0.51 -7.89 -0.4 4.26e-14 Bipolar disorder and schizophrenia; LUSC cis rs10781543 0.776 rs4378078 chr9:139375962 A/G cg14019695 chr9:139328340 INPP5E 0.52 10.09 0.48 4.57e-21 Monocyte percentage of white cells; LUSC cis rs4478858 0.647 rs4949380 chr1:31764160 A/G cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs8078723 1.000 rs4795416 chr17:38158133 C/T cg17467752 chr17:38218738 THRA 0.77 12.47 0.56 1.47e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg16928487 chr17:17741425 SREBF1 0.37 7.13 0.36 6.28e-12 Total body bone mineral density; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.2 0.52 6.11e-25 Prudent dietary pattern; LUSC trans rs12579753 1.000 rs10862368 chr12:82244514 C/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs9658691 0.607 rs9325604 chr10:90775756 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -6.25 -0.32 1.23e-9 Mosquito bite size; LUSC trans rs11039798 0.844 rs11040177 chr11:48976211 G/C cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs7180079 0.920 rs11071790 chr15:64601979 G/A cg08069370 chr15:64387884 SNX1 0.53 5.72 0.3 2.32e-8 Monocyte count; LUSC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg03676636 chr4:99064102 C4orf37 0.3 6.51 0.34 2.82e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs714027 0.585 rs9306468 chr22:30374281 T/C cg11564601 chr22:30592435 NA 0.34 5.69 0.3 2.8e-8 Lymphocyte counts; LUSC cis rs4474465 0.736 rs4945291 chr11:78254413 C/T cg27205649 chr11:78285834 NARS2 0.51 6.17 0.32 2.03e-9 Alzheimer's disease (survival time); LUSC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg04944784 chr2:26401820 FAM59B -0.7 -9.69 -0.47 9.59e-20 Gut microbiome composition (summer); LUSC cis rs4285028 0.747 rs9817818 chr3:121466826 C/A cg11130432 chr3:121712080 ILDR1 -0.53 -7.76 -0.39 1.02e-13 Multiple sclerosis; LUSC trans rs2228479 0.764 rs7186976 chr16:89961593 A/G cg24644049 chr4:85504048 CDS1 0.74 7.45 0.38 7.81e-13 Skin colour saturation; LUSC cis rs6977660 1.000 rs6943114 chr7:19818354 G/T cg05791153 chr7:19748676 TWISTNB 0.52 5.89 0.31 9.55e-9 Thyroid stimulating hormone; LUSC cis rs977987 0.898 rs12918974 chr16:75493943 T/A cg04384234 chr16:75411784 CFDP1 -0.48 -7.89 -0.4 4.26e-14 Dupuytren's disease; LUSC cis rs1843834 0.858 rs12105685 chr2:225513164 A/G cg22455342 chr2:225449267 CUL3 0.47 6.41 0.33 4.92e-10 IgE levels in asthmatics (D.p. specific); LUSC cis rs4561483 0.832 rs33645 chr16:11985201 T/C cg08843971 chr16:11963173 GSPT1 -0.48 -7.13 -0.36 6.11e-12 Testicular germ cell tumor; LUSC cis rs854765 0.583 rs11869536 chr17:17826528 T/A cg04398451 chr17:18023971 MYO15A -0.46 -7.4 -0.38 1.1e-12 Total body bone mineral density; LUSC cis rs7523050 0.643 rs35665867 chr1:109395436 G/A cg08274380 chr1:109419600 GPSM2 1.11 10.57 0.5 1.04e-22 Fat distribution (HIV); LUSC cis rs921968 0.613 rs2912737 chr2:219545789 A/G cg02176678 chr2:219576539 TTLL4 -0.59 -10.42 -0.5 3.24e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs78456975 1.000 rs11898988 chr2:1560336 G/A cg12573674 chr2:1569213 NA -0.55 -6.03 -0.31 4.38e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC trans rs2243480 0.901 rs3813708 chr7:65305632 C/A cg10756647 chr7:56101905 PSPH 0.88 8.45 0.42 8.8e-16 Diabetic kidney disease; LUSC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg03806693 chr22:41940476 POLR3H 1.0 14.25 0.62 2.41e-36 Vitiligo; LUSC cis rs1982963 0.906 rs2029976 chr14:52505811 C/T cg10843707 chr14:52510701 NID2 -0.4 -6.48 -0.33 3.2e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7799006 1.000 rs7787274 chr7:2275993 G/A cg02951883 chr7:2050386 MAD1L1 -0.34 -5.88 -0.31 9.99e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7113850 0.541 rs7129839 chr11:24208606 C/T ch.11.24196551F chr11:24239977 NA 0.96 7.47 0.38 7.26e-13 Bone fracture in osteoporosis; LUSC cis rs9837602 0.938 rs9823908 chr3:99795507 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.28 0.32 1.07e-9 Breast cancer; LUSC cis rs7666738 0.546 rs13141117 chr4:98892798 G/A cg03676636 chr4:99064102 C4orf37 0.31 6.25 0.32 1.26e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1215050 0.740 rs1648568 chr4:98957619 A/G cg05340658 chr4:99064831 C4orf37 -0.47 -7.44 -0.38 8.44e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg12751644 chr20:60527061 NA 0.36 6.22 0.32 1.51e-9 Body mass index; LUSC cis rs877282 1.000 rs877282 chr10:771532 G/A cg17470449 chr10:769945 NA 0.54 7.43 0.38 8.91e-13 Uric acid levels; LUSC cis rs8040855 0.627 rs11632899 chr15:85600840 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.38 -5.71 -0.3 2.51e-8 Bulimia nervosa; LUSC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg21433313 chr16:3507492 NAT15 0.7 11.47 0.53 6.94e-26 Tuberculosis; LUSC cis rs2637266 1.000 rs2579747 chr10:78327759 C/T cg18941641 chr10:78392320 NA 0.37 6.66 0.34 1.14e-10 Pulmonary function; LUSC cis rs11155671 0.530 rs7774787 chr6:150209432 G/A cg07701084 chr6:150067640 NUP43 0.46 6.96 0.36 1.8e-11 Testicular germ cell tumor; LUSC cis rs17001868 0.568 rs9611318 chr22:40739414 C/G cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs4144743 1.000 rs3809861 chr17:45330066 A/G cg18085866 chr17:45331354 ITGB3 -0.74 -7.72 -0.39 1.38e-13 Body mass index; LUSC cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.17 0.52 7.69e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs35883536 0.513 rs6577180 chr1:101016939 G/A cg06223162 chr1:101003688 GPR88 0.45 8.47 0.42 7.85e-16 Monocyte count; LUSC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg21918786 chr6:109611834 NA -0.4 -6.88 -0.35 2.97e-11 Reticulocyte fraction of red cells; LUSC cis rs738322 0.967 rs132985 chr22:38563471 C/T cg17652424 chr22:38574118 PLA2G6 -0.31 -6.9 -0.35 2.57e-11 Cutaneous nevi; LUSC cis rs6500602 0.727 rs6500607 chr16:4503631 C/T cg08645402 chr16:4508243 NA 0.53 9.12 0.45 7.36e-18 Schizophrenia; LUSC cis rs13031619 0.607 rs13011199 chr2:3694994 A/G cg25251562 chr2:3704773 ALLC 0.34 6.0 0.31 5.15e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs62103177 0.564 rs3930042 chr18:77723843 G/A cg02751453 chr18:77725136 HSBP1L1 -0.47 -6.14 -0.32 2.3e-9 Opioid sensitivity; LUSC cis rs12980942 0.591 rs2304232 chr19:41762525 A/G cg25627403 chr19:41769009 HNRNPUL1 0.69 7.34 0.37 1.69e-12 Coronary artery disease; LUSC cis rs2274273 0.662 rs60445539 chr14:55624245 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.7 0.47 9.24e-20 Protein biomarker; LUSC trans rs8072100 0.840 rs2136751 chr17:45456093 A/G cg04995722 chr7:26192034 NFE2L3 -0.4 -6.51 -0.34 2.7e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1670533 1.000 rs11725984 chr4:1087338 C/T cg27284194 chr4:1044797 NA 0.56 8.17 0.41 6.61e-15 Recombination rate (females); LUSC cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg04362960 chr10:104952993 NT5C2 0.6 9.43 0.46 7.29e-19 Arsenic metabolism; LUSC cis rs7091068 0.616 rs1409336 chr10:95479674 T/G cg20715218 chr10:95462985 C10orf4 0.61 6.79 0.35 5.14e-11 Urinary tract infection frequency; LUSC cis rs6963495 0.818 rs73192144 chr7:105203535 C/T cg13798780 chr7:105162888 PUS7 0.55 5.8 0.3 1.53e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6681460 0.549 rs7547866 chr1:67031924 A/G cg02459107 chr1:67143332 SGIP1 0.31 5.69 0.3 2.85e-8 Presence of antiphospholipid antibodies; LUSC cis rs2302729 0.929 rs7306298 chr12:2777311 G/A cg19945202 chr12:2788847 CACNA1C -0.39 -5.83 -0.3 1.33e-8 Sleep quality; LUSC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg16325326 chr1:53192061 ZYG11B 0.96 18.44 0.71 7.09e-53 Monocyte count; LUSC cis rs4786125 0.665 rs6500858 chr16:6906111 T/C cg03623568 chr16:6915990 A2BP1 -0.5 -8.0 -0.4 2.02e-14 Heart rate variability traits (SDNN); LUSC cis rs61990749 0.597 rs7147516 chr14:78153980 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.61 -6.49 -0.33 3.14e-10 Fibroblast growth factor basic levels; LUSC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg15468180 chr1:107600409 PRMT6 0.42 6.67 0.34 1.06e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9388451 0.839 rs3757217 chr6:126069636 G/C cg10911889 chr6:126070802 HEY2 0.43 6.54 0.34 2.28e-10 Brugada syndrome; LUSC cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7264396 1.000 rs7264396 chr20:34154741 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.47 6.85 0.35 3.49e-11 Total cholesterol levels; LUSC trans rs7824557 0.628 rs6988922 chr8:11194911 A/G cg06636001 chr8:8085503 FLJ10661 0.44 6.51 0.34 2.73e-10 Retinal vascular caliber; LUSC cis rs2070488 0.775 rs13098946 chr3:38517784 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.72 12.48 0.56 1.37e-29 Electrocardiographic conduction measures; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.56 -9.35 -0.46 1.35e-18 Lymphocyte counts; LUSC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.66 10.64 0.5 6.01e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg07817648 chr10:79422355 NA -0.54 -7.41 -0.38 1.06e-12 Bone mineral density; LUSC cis rs5769765 0.565 rs8137232 chr22:50256885 G/C cg02269571 chr22:50332266 NA 0.59 7.57 0.38 3.67e-13 Schizophrenia; LUSC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.33 0.62 1.18e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7481584 0.847 rs1468102 chr11:3004526 C/G cg08508325 chr11:3079039 CARS 0.31 5.97 0.31 6.05e-9 Calcium levels; LUSC cis rs1691799 0.867 rs1183274 chr12:66732057 C/G cg16791601 chr12:66731901 HELB -0.71 -12.65 -0.57 3.03e-30 White blood cell count (basophil); LUSC cis rs9346649 0.630 rs4708641 chr6:168491416 G/A cg02770688 chr6:168491649 NA 0.48 9.01 0.44 1.59e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg13010199 chr12:38710504 ALG10B 0.49 7.48 0.38 6.62e-13 Morning vs. evening chronotype; LUSC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.85 0.3 1.17e-8 Personality dimensions; LUSC cis rs6700559 0.740 rs10919999 chr1:200649759 G/A cg07804481 chr1:200639085 DDX59 0.41 5.77 0.3 1.85e-8 Coronary artery disease; LUSC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.97 0.31 6.23e-9 Schizophrenia; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg07677032 chr17:61819896 STRADA 0.55 9.2 0.45 4.08e-18 Prudent dietary pattern; LUSC cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg00409905 chr10:38381863 ZNF37A 0.35 5.97 0.31 6.21e-9 Extrinsic epigenetic age acceleration; LUSC cis rs981844 1.000 rs2606335 chr4:154656536 T/C cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.47 7.16 0.36 5.02e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg10896623 chr1:19923370 C1orf151 0.42 6.3 0.33 9.24e-10 Educational attainment (years of education); LUSC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg13206674 chr6:150067644 NUP43 0.57 8.99 0.44 1.91e-17 Lung cancer; LUSC trans rs61931739 0.559 rs4385974 chr12:34313128 G/C cg24313572 chr1:56050060 NA -0.31 -6.32 -0.33 8.32e-10 Morning vs. evening chronotype; LUSC cis rs2235649 0.789 rs4567715 chr16:1849363 G/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.09 -0.32 3.19e-9 Blood metabolite levels; LUSC cis rs9287719 0.967 rs10195802 chr2:10754532 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2832077 0.943 rs2832106 chr21:30191767 A/G cg24692254 chr21:30365293 RNF160 -0.58 -7.22 -0.37 3.57e-12 Cognitive test performance; LUSC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg00701064 chr4:6280414 WFS1 0.58 14.12 0.61 8.04e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6964587 1.000 rs12536529 chr7:91684086 C/T cg17063962 chr7:91808500 NA -0.59 -9.31 -0.45 1.74e-18 Breast cancer; LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg13628971 chr7:2884303 GNA12 0.48 6.82 0.35 4.2e-11 Height; LUSC cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg04034577 chr2:241836375 C2orf54 -0.5 -9.18 -0.45 4.72e-18 Urinary metabolites; LUSC cis rs35883536 0.611 rs72977390 chr1:101107147 C/T cg06223162 chr1:101003688 GPR88 0.34 6.16 0.32 2.05e-9 Monocyte count; LUSC cis rs7264396 0.887 rs2236160 chr20:34101821 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.69 -0.34 9.21e-11 Total cholesterol levels; LUSC cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.2 0.49 1.95e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11644478 chr21:40555479 PSMG1 0.85 14.57 0.62 1.41e-37 Cognitive function; LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.31 0.53 2.45e-25 Menopause (age at onset); LUSC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg21963583 chr11:68658836 MRPL21 -0.5 -7.59 -0.38 3.32e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1113500 0.548 rs6583062 chr1:108656463 G/A cg06207961 chr1:108661230 NA 0.37 6.13 0.32 2.45e-9 Growth-regulated protein alpha levels; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11098499 0.863 rs10004484 chr4:120442428 C/T cg24375607 chr4:120327624 NA 0.77 11.22 0.52 5.07e-25 Corneal astigmatism; LUSC cis rs8062405 1.000 rs62037364 chr16:28868695 G/A cg09754948 chr16:28834200 ATXN2L 0.41 5.96 0.31 6.27e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11098499 0.863 rs10034450 chr4:120455649 A/G cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs239198 0.568 rs9404059 chr6:101331497 T/C cg09795085 chr6:101329169 ASCC3 0.42 6.01 0.31 4.77e-9 Menarche (age at onset); LUSC cis rs360798 0.512 rs4671050 chr2:62988169 G/T cg17519650 chr2:63277830 OTX1 -0.51 -7.08 -0.36 8.37e-12 Coronary artery disease; LUSC cis rs911119 0.954 rs2405367 chr20:23622880 A/G cg16589663 chr20:23618590 CST3 -0.64 -7.84 -0.39 6.27e-14 Chronic kidney disease; LUSC cis rs9527 0.615 rs7073295 chr10:104672233 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.02 0.4 1.85e-14 Arsenic metabolism; LUSC cis rs9527 0.590 rs11191553 chr10:104851396 G/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.61 -0.34 1.54e-10 Arsenic metabolism; LUSC cis rs72781680 1.000 rs72796351 chr2:24158425 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs713587 0.563 rs1529897 chr2:25086827 T/G cg15423357 chr2:25149977 NA 0.39 7.5 0.38 5.99e-13 Body mass index in non-asthmatics; LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg08280861 chr8:58055591 NA 0.54 6.43 0.33 4.34e-10 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20196129 chr10:31609347 ZEB1;LOC220930 -0.51 -6.23 -0.32 1.38e-9 Bipolar disorder and schizophrenia; LUSC cis rs936229 1.000 rs936229 chr15:75132319 A/G cg14664628 chr15:75095509 CSK -0.9 -14.11 -0.61 8.46e-36 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7592578 0.508 rs10931451 chr2:191270888 G/A cg10560079 chr2:191398806 TMEM194B -0.52 -6.67 -0.34 1.03e-10 Diastolic blood pressure; LUSC cis rs7074356 0.569 rs7090863 chr10:82021393 C/A cg27171509 chr10:82033454 MAT1A -0.32 -5.85 -0.3 1.18e-8 Borderline personality disorder; LUSC cis rs7677751 0.806 rs7679903 chr4:55097373 T/C cg17187183 chr4:55093834 PDGFRA 0.39 5.89 0.31 9.61e-9 Corneal astigmatism; LUSC trans rs9929218 1.000 rs13330350 chr16:68800849 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.53 -0.53 4.11e-26 Colorectal cancer; LUSC cis rs11190604 1.000 rs9420797 chr10:102331147 C/T cg16342193 chr10:102329863 NA -0.36 -7.14 -0.36 6.03e-12 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10911232 0.507 rs10732271 chr1:183025898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 11.09 0.52 1.56e-24 Hypertriglyceridemia; LUSC cis rs668210 0.739 rs1151511 chr11:65756283 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.59 7.82 0.39 6.97e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg17420585 chr12:42539391 GXYLT1 -0.37 -7.11 -0.36 7.28e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs727505 0.954 rs68102397 chr7:124685315 C/T cg23710748 chr7:124431027 NA -0.41 -7.15 -0.36 5.37e-12 Lewy body disease; LUSC cis rs10465746 0.752 rs10874426 chr1:84451820 A/G cg10977910 chr1:84465055 TTLL7 0.5 7.35 0.37 1.54e-12 Obesity-related traits; LUSC cis rs3126085 0.935 rs4326625 chr1:152223996 C/T cg26876637 chr1:152193138 HRNR 0.39 5.65 0.3 3.48e-8 Atopic dermatitis; LUSC cis rs5758511 0.773 rs73165164 chr22:42355549 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.93 -0.31 7.54e-9 Birth weight; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg27094323 chr7:1216898 NA -0.45 -7.8 -0.39 8.07e-14 Longevity;Endometriosis; LUSC cis rs3931020 0.657 rs277376 chr1:75242246 G/T cg10128416 chr1:75198403 TYW3;CRYZ -0.6 -8.02 -0.4 1.78e-14 Resistin levels; LUSC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.85 0.3 1.18e-8 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23381116 chr14:24616413 PSME2;RNF31 0.44 6.27 0.32 1.12e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4654899 0.802 rs2290381 chr1:21213271 C/A cg01072550 chr1:21505969 NA -0.48 -7.06 -0.36 9.83e-12 Superior frontal gyrus grey matter volume; LUSC cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg05855489 chr10:104503620 C10orf26 0.59 9.19 0.45 4.16e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg21724239 chr8:58056113 NA 0.75 8.54 0.42 4.93e-16 Developmental language disorder (linguistic errors); LUSC cis rs208520 0.954 rs1468153 chr6:67009054 A/C cg07460842 chr6:66804631 NA 0.89 9.68 0.47 1.1e-19 Exhaled nitric oxide output; LUSC cis rs7914558 0.505 rs12260436 chr10:104741114 A/C cg04362960 chr10:104952993 NT5C2 0.69 9.42 0.46 7.98e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1865721 1.000 rs1865721 chr18:73192446 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -8.1 -0.41 1.04e-14 Intelligence; LUSC cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.34 -0.33 7.64e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg03676636 chr4:99064102 C4orf37 0.36 8.07 0.4 1.24e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg13298116 chr11:62369859 EML3;MTA2 0.5 8.68 0.43 1.82e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -9.85 -0.47 2.9e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg17178900 chr1:205818956 PM20D1 0.94 18.7 0.72 6.71e-54 Menarche (age at onset); LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.43 -7.95 -0.4 2.83e-14 Monocyte percentage of white cells; LUSC cis rs6840360 0.571 rs11944139 chr4:152505291 T/C cg22705602 chr4:152727874 NA -0.32 -6.37 -0.33 6.24e-10 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg10018233 chr7:150070692 REPIN1 0.4 7.16 0.36 5.1e-12 Blood protein levels;Circulating chemerin levels; LUSC trans rs9329221 0.537 rs1351876 chr8:9984777 A/G cg15556689 chr8:8085844 FLJ10661 -0.52 -8.0 -0.4 2.12e-14 Neuroticism; LUSC cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg12292205 chr6:26970375 C6orf41 0.37 5.78 0.3 1.7e-8 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.49 0.33 3.13e-10 Lung cancer; LUSC cis rs4234798 0.500 rs7661066 chr4:7219878 C/T cg18431297 chr4:7219810 SORCS2 0.33 6.21 0.32 1.55e-9 Insulin-like growth factors; LUSC cis rs5769707 0.609 rs739247 chr22:49996657 T/C cg05373962 chr22:49881684 NA -0.4 -8.63 -0.43 2.63e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.87 -12.37 -0.56 3.29e-29 Platelet count; LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.13 0.41 8.73e-15 Bipolar disorder; LUSC trans rs61931739 0.890 rs1705748 chr12:34133171 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.95 0.36 1.93e-11 Morning vs. evening chronotype; LUSC cis rs4319547 0.737 rs11058226 chr12:122938958 A/G cg23029597 chr12:123009494 RSRC2 -0.63 -7.38 -0.37 1.28e-12 Body mass index; LUSC cis rs1595825 1.000 rs79508374 chr2:198864568 G/A cg00982548 chr2:198649783 BOLL -0.5 -6.22 -0.32 1.46e-9 Ulcerative colitis; LUSC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg04398451 chr17:18023971 MYO15A -0.46 -7.38 -0.37 1.31e-12 Total body bone mineral density; LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.77 0.43 9.36e-17 Alzheimer's disease; LUSC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg16339924 chr4:17578868 LAP3 0.56 8.54 0.42 4.9e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.77 0.3 1.82e-8 Personality dimensions; LUSC cis rs701145 0.585 rs357477 chr3:153892717 A/G cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.12e-11 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01469421 chr19:57999034 ZNF419 0.42 6.68 0.34 1.03e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs61931739 0.534 rs10844801 chr12:34230940 A/T cg06521331 chr12:34319734 NA -0.45 -7.59 -0.38 3.32e-13 Morning vs. evening chronotype; LUSC cis rs9303401 0.659 rs714959 chr17:56628601 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.83 13.11 0.58 5.75e-32 Cognitive test performance; LUSC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg17971929 chr21:40555470 PSMG1 0.77 13.48 0.59 2.3e-33 Cognitive function; LUSC cis rs908922 0.676 rs2282296 chr1:152487979 C/T cg20991723 chr1:152506922 NA 0.53 9.8 0.47 4.42e-20 Hair morphology; LUSC cis rs6500602 0.727 rs55939215 chr16:4541390 C/G cg08645402 chr16:4508243 NA 0.49 8.11 0.41 9.77e-15 Schizophrenia; LUSC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg05872129 chr22:39784769 NA -0.54 -8.93 -0.44 2.91e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs13256369 0.865 rs13277708 chr8:8573936 T/C cg00074818 chr8:8560427 CLDN23 0.53 9.16 0.45 5.19e-18 Obesity-related traits; LUSC cis rs6545883 0.929 rs2121660 chr2:61653058 T/C cg15711740 chr2:61764176 XPO1 0.45 6.87 0.35 3.24e-11 Tuberculosis; LUSC cis rs4481887 0.512 rs1538702 chr1:248519665 A/T cg26353448 chr1:248524236 OR2T4 -0.42 -9.48 -0.46 4.87e-19 Common traits (Other); LUSC trans rs208520 0.874 rs208469 chr6:66915891 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -14.01 -0.61 2.11e-35 Exhaled nitric oxide output; LUSC cis rs8114671 0.967 rs6058202 chr20:33777983 A/G cg07148914 chr20:33460835 GGT7 0.46 6.74 0.35 6.97e-11 Height; LUSC cis rs367615 0.704 rs7704824 chr5:108850278 A/G cg17395555 chr5:108820864 NA 0.52 10.01 0.48 8.64e-21 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9325144 0.560 rs1843911 chr12:38676585 C/T cg13010199 chr12:38710504 ALG10B -0.52 -7.88 -0.4 4.69e-14 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg18404041 chr3:52824283 ITIH1 -0.6 -11.57 -0.53 2.91e-26 Bipolar disorder; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg07157834 chr1:205819609 PM20D1 -0.81 -14.5 -0.62 2.79e-37 Menarche (age at onset); LUSC cis rs2708977 0.933 rs2579502 chr2:97198800 A/G cg01950434 chr2:97203154 ARID5A -0.57 -8.49 -0.42 6.68e-16 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg23034840 chr1:205782522 SLC41A1 0.59 8.29 0.41 2.81e-15 Menarche (age at onset); LUSC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg06558623 chr16:89946397 TCF25 1.08 9.74 0.47 6.73e-20 Skin colour saturation; LUSC cis rs7945718 0.967 rs11022490 chr11:12773526 C/G cg25843174 chr11:12811716 TEAD1 -0.3 -6.83 -0.35 4.11e-11 Educational attainment (years of education); LUSC cis rs9469578 0.579 rs73743310 chr6:33689299 A/G cg18708504 chr6:33715942 IP6K3 0.67 6.33 0.33 7.75e-10 Phosphorus levels; LUSC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg15744005 chr10:104629667 AS3MT -0.38 -7.8 -0.39 8.23e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7264396 0.775 rs2296402 chr20:34054729 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.23 -0.32 1.4e-9 Total cholesterol levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02725935 chr1:120612404 NOTCH2 0.48 6.66 0.34 1.13e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs427394 0.593 rs880993 chr5:6732120 C/G cg10857441 chr5:6722123 POLS -0.45 -8.31 -0.41 2.44e-15 Menopause (age at onset); LUSC cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.94 -0.31 7.19e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs76878669 0.561 rs2279862 chr11:66135179 C/T cg18002602 chr11:66138449 SLC29A2 0.45 8.1 0.41 1.06e-14 Educational attainment (years of education); LUSC cis rs17818399 0.547 rs13020299 chr2:46758717 A/G cg21681030 chr2:46777652 RHOQ 0.42 5.92 0.31 7.79e-9 Height; LUSC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg05313129 chr8:58192883 C8orf71 -0.53 -6.86 -0.35 3.31e-11 Developmental language disorder (linguistic errors); LUSC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg20607287 chr7:12443886 VWDE -0.57 -6.03 -0.31 4.43e-9 Coronary artery disease; LUSC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs72627509 0.904 rs3796529 chr4:57797414 C/T cg26694713 chr4:57773883 REST 0.49 6.06 0.31 3.76e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 6.91 0.35 2.53e-11 Platelet count; LUSC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg09165964 chr15:75287851 SCAMP5 0.47 7.11 0.36 6.9e-12 Breast cancer; LUSC cis rs11098499 0.779 rs7356491 chr4:120381974 C/T cg24375607 chr4:120327624 NA 0.77 11.46 0.53 7.47e-26 Corneal astigmatism; LUSC cis rs6939532 0.522 rs9379870 chr6:26374410 A/G cg09904177 chr6:26538194 HMGN4 -0.45 -6.44 -0.33 4.09e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs559928 1.000 rs11601872 chr11:64147627 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.65 6.61 0.34 1.52e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2742234 0.554 rs1254963 chr10:43696086 C/T cg02780029 chr10:43622663 RET 0.34 5.65 0.3 3.37e-8 Hirschsprung disease; LUSC cis rs4319547 0.737 rs10773176 chr12:122944713 A/G cg23029597 chr12:123009494 RSRC2 -0.71 -9.45 -0.46 6.22e-19 Body mass index; LUSC cis rs3857536 0.776 rs4710583 chr6:66940101 A/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs1577917 0.771 rs7762321 chr6:86412146 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 9.43 0.46 7.3e-19 Response to antipsychotic treatment; LUSC cis rs113835537 0.529 rs2305535 chr11:66272237 A/G cg24851651 chr11:66362959 CCS -0.49 -7.37 -0.37 1.39e-12 Airway imaging phenotypes; LUSC cis rs952623 0.501 rs12671046 chr7:39081866 C/T cg15212455 chr7:39170539 POU6F2 -0.37 -5.67 -0.3 3.11e-8 Intelligence (multi-trait analysis); LUSC cis rs754466 0.580 rs2289311 chr10:79565655 G/A cg17075019 chr10:79541650 NA -0.68 -10.39 -0.49 4.2e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13256369 0.802 rs11781257 chr8:8559663 A/T cg00074818 chr8:8560427 CLDN23 0.59 9.54 0.46 3.07e-19 Obesity-related traits; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg25135922 chr1:226497286 LIN9 0.4 6.11 0.32 2.77e-9 Schizophrenia (age at onset); LUSC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.47 7.05 0.36 1.02e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs7605827 0.930 rs2111453 chr2:15673248 C/T cg19274914 chr2:15703543 NA 0.45 8.7 0.43 1.49e-16 Educational attainment (years of education); LUSC trans rs459571 0.920 rs433402 chr9:136898627 A/G cg10765909 chr12:53715428 AAAS -0.43 -6.15 -0.32 2.17e-9 Platelet distribution width; LUSC cis rs9875589 0.509 rs2733548 chr3:14094478 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 7.0 0.36 1.45e-11 Ovarian reserve; LUSC cis rs4478137 0.931 rs7687423 chr4:164250797 C/T cg06758707 chr4:164254230 NPY1R -0.6 -9.7 -0.47 9.41e-20 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg03146154 chr1:46216737 IPP 0.53 7.72 0.39 1.33e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs6502050 0.835 rs10163496 chr17:80110867 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs3008870 1.000 rs2985822 chr1:67404910 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.13 0.64 9.65e-40 Lymphocyte percentage of white cells; LUSC trans rs9291683 0.530 rs882223 chr4:9981625 A/C cg26043149 chr18:55253948 FECH 0.47 7.16 0.36 5.05e-12 Bone mineral density; LUSC cis rs6845621 0.717 rs2222192 chr4:18844340 G/A cg12196642 chr4:18937545 NA -0.32 -5.8 -0.3 1.53e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg16339924 chr4:17578868 LAP3 0.6 9.22 0.45 3.34e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12216125 0.537 rs12207059 chr6:25922385 C/T cg16482183 chr6:26056742 HIST1H1C 1.0 12.85 0.58 5.41e-31 Iron status biomarkers; LUSC cis rs782590 0.902 rs2586947 chr2:55854009 C/G cg18811423 chr2:55921094 PNPT1 0.78 13.35 0.59 6.83e-33 Metabolic syndrome; LUSC trans rs9329221 0.905 rs28507213 chr8:10250849 C/T cg15556689 chr8:8085844 FLJ10661 -0.62 -9.44 -0.46 6.8e-19 Neuroticism; LUSC trans rs804280 1.000 rs804280 chr8:11612698 G/T cg27411982 chr8:10470053 RP1L1 0.4 6.23 0.32 1.37e-9 Myopia (pathological); LUSC cis rs11098499 0.691 rs2136911 chr4:120265859 G/A cg24375607 chr4:120327624 NA 0.69 10.92 0.51 6.06e-24 Corneal astigmatism; LUSC cis rs10779751 0.770 rs2486922 chr1:11124885 T/C cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg06600287 chr1:53387719 ECHDC2 -0.3 -6.28 -0.33 1.04e-9 Monocyte count; LUSC cis rs7917772 0.582 rs10786680 chr10:104317192 A/G cg22532475 chr10:104410764 TRIM8 -0.26 -6.06 -0.31 3.64e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7208859 0.562 rs8078897 chr17:29106257 T/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg05234568 chr11:5960015 NA -0.57 -8.48 -0.42 7.41e-16 DNA methylation (variation); LUSC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.21 -0.49 1.74e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6087990 0.735 rs2424921 chr20:31385814 C/T cg13636640 chr20:31349939 DNMT3B 0.92 18.85 0.72 1.63e-54 Ulcerative colitis; LUSC cis rs6828523 0.698 rs56004315 chr4:175859382 C/T cg16870595 chr4:175839423 ADAM29 0.5 5.67 0.3 3.09e-8 Breast cancer; LUSC cis rs9326248 0.731 rs90192 chr11:117059347 C/T cg26566898 chr11:117069891 TAGLN 0.39 5.84 0.3 1.26e-8 Blood protein levels; LUSC cis rs12545109 0.842 rs2670050 chr8:57402914 T/G cg09654669 chr8:57350985 NA -0.5 -6.54 -0.34 2.34e-10 Obesity-related traits; LUSC cis rs8017423 0.967 rs12889636 chr14:90689953 A/C cg04374321 chr14:90722782 PSMC1 -0.68 -10.22 -0.49 1.66e-21 Mortality in heart failure; LUSC cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg22496339 chr2:162101262 NA -0.57 -7.41 -0.38 1.03e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); LUSC cis rs2970818 0.831 rs11063205 chr12:4597745 G/A cg11146114 chr12:4671731 NA -0.62 -5.99 -0.31 5.57e-9 Phosphorus levels; LUSC cis rs793571 0.650 rs12899638 chr15:58920275 G/A cg05156742 chr15:59063176 FAM63B 0.56 8.53 0.42 5.14e-16 Schizophrenia; LUSC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg09796270 chr17:17721594 SREBF1 0.43 7.6 0.38 2.97e-13 Total body bone mineral density; LUSC cis rs2439831 0.717 rs28495368 chr15:43895642 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg13939156 chr17:80058883 NA -0.34 -6.73 -0.35 7.53e-11 Life satisfaction; LUSC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg17077180 chr1:38461687 NA 0.4 6.09 0.32 3.18e-9 Coronary artery disease; LUSC trans rs877282 0.842 rs35872126 chr10:764545 G/A cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg09658497 chr7:2847517 GNA12 -0.32 -5.72 -0.3 2.42e-8 Height; LUSC cis rs2250402 0.510 rs7535 chr15:40328575 G/C cg10636054 chr15:40330586 SRP14 0.91 9.01 0.44 1.63e-17 Corneal curvature; LUSC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs2625529 0.824 rs7170754 chr15:72218594 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.51 -0.38 5.28e-13 Red blood cell count; LUSC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg24324837 chr19:49891574 CCDC155 0.51 6.94 0.35 2.05e-11 Multiple sclerosis; LUSC cis rs9326248 0.581 rs7106437 chr11:116992076 T/C cg10130564 chr11:117069849 TAGLN 0.33 6.31 0.33 9.01e-10 Blood protein levels; LUSC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg04121214 chr22:50244548 NA -0.35 -5.77 -0.3 1.82e-8 Schizophrenia; LUSC cis rs8060686 0.641 rs75796305 chr16:68208791 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs10492096 0.947 rs11064227 chr12:6598043 A/G cg13857086 chr12:6580257 VAMP1 0.59 7.11 0.36 7.22e-12 Hip geometry; LUSC cis rs7267979 1.000 rs2257496 chr20:25279315 A/G cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg03433033 chr1:76189801 ACADM 0.75 10.36 0.49 5.28e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4704187 0.687 rs1422696 chr5:74464415 T/C cg03227963 chr5:74354835 NA 0.32 6.83 0.35 4.02e-11 Response to amphetamines; LUSC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg18240062 chr17:79603768 NPLOC4 -0.57 -9.84 -0.47 3.25e-20 Eye color traits; LUSC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg24531977 chr5:56204891 C5orf35 -0.55 -8.16 -0.41 7.13e-15 Coronary artery disease; LUSC trans rs62238980 0.614 rs75386630 chr22:32380975 G/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs3784262 1.000 rs4646629 chr15:58255215 A/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.8 -0.3 1.51e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs1670533 1.000 rs6857085 chr4:1095920 C/A cg02018176 chr4:1364513 KIAA1530 -0.45 -6.25 -0.32 1.22e-9 Recombination rate (females); LUSC cis rs11098499 0.566 rs7664440 chr4:120578540 A/G cg24375607 chr4:120327624 NA 0.72 10.44 0.5 2.84e-22 Corneal astigmatism; LUSC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg09359103 chr1:154839909 KCNN3 0.43 8.34 0.42 1.97e-15 Schizophrenia; LUSC cis rs7264396 0.635 rs6058366 chr20:34512172 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.94 -0.44 2.7e-17 Total cholesterol levels; LUSC trans rs11098499 0.863 rs3822190 chr4:120428098 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.18 0.32 1.85e-9 Corneal astigmatism; LUSC cis rs5758511 0.508 rs58099562 chr22:42453772 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.54 -6.34 -0.33 7.27e-10 Birth weight; LUSC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg15494558 chr6:150152522 LRP11 0.34 5.77 0.3 1.77e-8 Lung cancer; LUSC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.58 -0.38 3.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 3e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9916302 0.861 rs7503514 chr17:37669884 G/C cg15445000 chr17:37608096 MED1 0.41 6.91 0.35 2.41e-11 Glomerular filtration rate (creatinine); LUSC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg25174290 chr11:3078921 CARS 0.61 9.47 0.46 5.11e-19 Longevity; LUSC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg08236123 chr12:132219811 SFRS8 -0.43 -6.54 -0.34 2.36e-10 Migraine; LUSC cis rs1865760 0.519 rs4360119 chr6:25815074 C/G cg16482183 chr6:26056742 HIST1H1C 0.61 8.39 0.42 1.36e-15 Height; LUSC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg09197432 chr4:183729176 NA 0.69 9.8 0.47 4.33e-20 Pediatric autoimmune diseases; LUSC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg09365446 chr1:150670422 GOLPH3L 0.54 8.41 0.42 1.24e-15 Tonsillectomy; LUSC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg26335602 chr6:28129616 ZNF389 0.43 5.75 0.3 1.98e-8 Parkinson's disease; LUSC trans rs61931739 0.500 rs10844829 chr12:34304916 G/T cg26384229 chr12:38710491 ALG10B 0.73 11.84 0.54 3.15e-27 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.79 0.6 1.52e-34 Alzheimer's disease; LUSC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs1113500 0.897 rs4628530 chr1:108638708 T/G cg06207961 chr1:108661230 NA 0.41 7.64 0.39 2.29e-13 Growth-regulated protein alpha levels; LUSC cis rs3126085 0.877 rs1969019 chr1:152211502 A/C cg26876637 chr1:152193138 HRNR 0.45 6.27 0.32 1.12e-9 Atopic dermatitis; LUSC cis rs59918340 0.728 rs6987335 chr8:142235358 T/G cg23750338 chr8:142222470 SLC45A4 -0.54 -10.21 -0.49 1.82e-21 Immature fraction of reticulocytes; LUSC cis rs6596100 0.538 rs55976357 chr5:132194565 C/A cg02081065 chr5:132209139 LEAP2 -0.62 -5.9 -0.31 9.1e-9 Breast cancer; LUSC cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -8.2 -0.41 5.39e-15 Chronic sinus infection; LUSC cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.59 -7.97 -0.4 2.51e-14 Body mass index (adult); LUSC cis rs929354 0.772 rs7778193 chr7:156980087 C/T cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs9611519 0.780 rs9611527 chr22:41644428 G/A cg03806693 chr22:41940476 POLR3H -0.54 -7.91 -0.4 3.76e-14 Neuroticism; LUSC cis rs4588572 0.537 rs7705718 chr5:77730349 T/C cg11547950 chr5:77652471 NA -0.48 -7.19 -0.37 4.18e-12 Triglycerides; LUSC cis rs9379945 1 rs9379945 chr6:26907831 T/C cg12826209 chr6:26865740 GUSBL1 0.79 7.96 0.4 2.68e-14 Intelligence (multi-trait analysis); LUSC cis rs11190604 0.767 rs3750723 chr10:102172989 T/C cg07080220 chr10:102295463 HIF1AN 0.6 7.75 0.39 1.1e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3820928 0.934 rs16822890 chr2:227761477 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.74 -0.39 1.21e-13 Pulmonary function; LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg11645453 chr3:52864694 ITIH4 0.34 7.78 0.39 8.92e-14 Bipolar disorder; LUSC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg00033643 chr7:134001901 SLC35B4 0.42 6.71 0.34 8.2e-11 Mean platelet volume; LUSC cis rs151349 1.000 rs151345 chr20:57586849 G/C cg23907860 chr20:57583709 CTSZ -0.46 -7.47 -0.38 6.97e-13 Platelet distribution width; LUSC cis rs4363385 0.934 rs4240865 chr1:152954839 G/T cg08895932 chr1:152778580 LCE1C 0.34 5.8 0.3 1.52e-8 Inflammatory skin disease; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg06303282 chr4:154266565 MND1 0.53 6.18 0.32 1.86e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08109568 chr15:31115862 NA 0.48 6.64 0.34 1.3e-10 Huntington's disease progression; LUSC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg00129232 chr17:37814104 STARD3 -0.47 -7.03 -0.36 1.18e-11 Asthma; LUSC cis rs8038465 0.762 rs35149321 chr15:73962728 G/A cg15420318 chr15:73925796 NPTN 0.52 8.68 0.43 1.79e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1005277 0.505 rs200936 chr10:38134935 T/C cg17830980 chr10:43048298 ZNF37B -0.43 -6.64 -0.34 1.26e-10 Extrinsic epigenetic age acceleration; LUSC trans rs12310956 0.532 rs11494810 chr12:33952881 C/A cg26384229 chr12:38710491 ALG10B 0.71 11.0 0.52 3.29e-24 Morning vs. evening chronotype; LUSC cis rs314370 0.951 rs12705092 chr7:100473550 G/A cg08558340 chr7:100472263 SRRT 0.5 6.23 0.32 1.37e-9 Resting heart rate; LUSC cis rs250677 0.958 rs36067 chr5:148417553 T/G cg23229984 chr5:148520753 ABLIM3 0.37 5.97 0.31 6.15e-9 Breast cancer; LUSC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs11645898 0.687 rs72787058 chr16:72105084 C/T cg14768367 chr16:72042858 DHODH -0.53 -6.15 -0.32 2.16e-9 Blood protein levels; LUSC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg19622623 chr12:86230825 RASSF9 -0.46 -6.39 -0.33 5.57e-10 Major depressive disorder; LUSC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg05785598 chr3:49045655 WDR6 0.37 6.61 0.34 1.52e-10 Parkinson's disease; LUSC cis rs12891047 0.901 rs1040598 chr14:68258982 C/A cg20999565 chr14:68265668 ZFYVE26 -0.39 -6.03 -0.31 4.34e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs3764563 1.000 rs3764563 chr19:15724203 A/G cg20725493 chr19:15740067 CYP4F8 -0.56 -6.56 -0.34 2.05e-10 Inflammatory biomarkers; LUSC cis rs1908814 0.516 rs4841641 chr8:11798227 G/A cg21775007 chr8:11205619 TDH 0.46 6.48 0.33 3.26e-10 Neuroticism; LUSC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg22244940 chr12:132335942 MMP17 -0.44 -6.77 -0.35 5.83e-11 Migraine; LUSC cis rs4919694 0.572 rs12255989 chr10:104867206 C/T cg04362960 chr10:104952993 NT5C2 0.9 11.69 0.54 1.06e-26 Arsenic metabolism; LUSC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg24733560 chr20:60626293 TAF4 0.4 6.39 0.33 5.49e-10 Body mass index; LUSC cis rs9677476 1.000 rs12470450 chr2:232113888 T/A cg07929768 chr2:232055508 NA 0.3 5.78 0.3 1.7e-8 Food antigen IgG levels; LUSC cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs3106136 0.967 rs7435106 chr4:95169772 T/A cg11021082 chr4:95130006 SMARCAD1 -0.36 -6.32 -0.33 8.37e-10 Capecitabine sensitivity; LUSC cis rs4478858 0.735 rs2271072 chr1:31840426 C/G cg00250761 chr1:31883323 NA -0.36 -8.67 -0.43 1.97e-16 Alcohol dependence; LUSC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg18252515 chr7:66147081 NA 1.22 13.75 0.6 2.15e-34 Diabetic kidney disease; LUSC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.17e-10 Aortic root size; LUSC cis rs7824557 0.527 rs4634600 chr8:11239017 T/A cg27411982 chr8:10470053 RP1L1 -0.36 -5.8 -0.3 1.56e-8 Retinal vascular caliber; LUSC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg07092213 chr7:1199455 ZFAND2A -0.42 -6.71 -0.34 8.42e-11 Longevity;Endometriosis; LUSC cis rs17685 0.767 rs10954732 chr7:75611149 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.44 6.92 0.35 2.28e-11 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg27539214 chr16:67997921 SLC12A4 -0.52 -7.06 -0.36 9.75e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs7615316 0.779 rs13061823 chr3:142120786 C/T cg16271453 chr3:142027066 XRN1 -0.41 -7.19 -0.37 4.17e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg19592336 chr6:28129416 ZNF389 0.53 6.95 0.36 1.87e-11 Parkinson's disease; LUSC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg13175981 chr1:150552382 MCL1 -0.41 -5.65 -0.3 3.53e-8 Melanoma; LUSC cis rs66887589 0.774 rs9307477 chr4:120421809 G/A cg24375607 chr4:120327624 NA 0.51 7.87 0.4 4.87e-14 Diastolic blood pressure; LUSC cis rs2594714 1.000 rs2594714 chr19:13954571 G/A cg18576835 chr19:13944261 NA -0.39 -5.67 -0.3 3.11e-8 Breast cancer; LUSC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg07212818 chr11:638076 DRD4 -0.44 -7.37 -0.37 1.36e-12 Systemic lupus erythematosus; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg11645453 chr3:52864694 ITIH4 0.35 8.23 0.41 4.18e-15 Bipolar disorder; LUSC cis rs4964805 0.657 rs73192049 chr12:104187993 T/C cg02344784 chr12:104178138 NT5DC3 0.46 8.87 0.44 4.61e-17 Attention deficit hyperactivity disorder; LUSC cis rs1832871 0.672 rs9456285 chr6:158732819 T/G cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -10.29 -0.49 9.04e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11246602 1 rs11246602 chr11:51512090 T/C cg03929089 chr4:120376271 NA 0.79 6.7 0.34 8.71e-11 HDL cholesterol levels;HDL cholesterol; LUSC cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14240646 chr10:27532245 ACBD5 -0.74 -8.14 -0.41 8.13e-15 Breast cancer; LUSC cis rs728616 0.558 rs12772945 chr10:82154496 C/T cg05935833 chr10:81318306 SFTPA2 -0.44 -5.8 -0.3 1.57e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg00071950 chr4:10020882 SLC2A9 0.67 11.22 0.52 5.3e-25 Bone mineral density; LUSC cis rs9372253 0.678 rs6568644 chr6:110707820 C/T cg00083206 chr6:110721305 DDO -0.44 -7.91 -0.4 3.8e-14 Platelet distribution width; LUSC cis rs3820928 0.874 rs13403281 chr2:227880769 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.71 -0.39 1.49e-13 Pulmonary function; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.42 0.76 1.15e-64 Prudent dietary pattern; LUSC cis rs4478137 0.501 rs4146926 chr4:164230788 C/G cg06758707 chr4:164254230 NPY1R -0.52 -6.93 -0.35 2.13e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg16414030 chr3:133502952 NA 0.35 5.67 0.3 3.06e-8 Alcohol consumption (transferrin glycosylation); LUSC cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.86 12.59 0.57 5.41e-30 Chronic sinus infection; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg01802117 chr1:53393560 SCP2 -0.36 -5.79 -0.3 1.62e-8 Monocyte count; LUSC cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg24812749 chr6:127587940 RNF146 0.92 13.86 0.6 7.98e-35 Breast cancer; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.9 0.44 3.49e-17 Prudent dietary pattern; LUSC trans rs1459104 0.866 rs12787024 chr11:54883667 C/T cg03929089 chr4:120376271 NA 0.68 6.03 0.31 4.28e-9 Body mass index; LUSC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg09491104 chr22:46646882 C22orf40 -0.64 -7.38 -0.37 1.3e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg01097406 chr16:89675127 NA 0.31 6.06 0.31 3.71e-9 Vitiligo; LUSC cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg01884057 chr2:25150051 NA 0.48 11.31 0.53 2.52e-25 Body mass index; LUSC cis rs9640161 0.830 rs17173703 chr7:150068620 C/T cg10018233 chr7:150070692 REPIN1 0.4 7.11 0.36 6.9e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg12963246 chr6:28129442 ZNF389 0.53 7.5 0.38 5.9e-13 Depression; LUSC cis rs4891159 0.527 rs689642 chr18:74119120 A/C cg24786174 chr18:74118243 ZNF516 0.97 21.02 0.75 4.14e-63 Longevity; LUSC cis rs1801251 0.752 rs2675966 chr2:233735543 T/C cg08000102 chr2:233561755 GIGYF2 -0.51 -8.11 -0.41 9.53e-15 Coronary artery disease; LUSC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg13393036 chr8:95962371 TP53INP1 -0.44 -9.15 -0.45 5.61e-18 Type 2 diabetes; LUSC cis rs662064 0.925 rs597438 chr1:10554505 A/G cg20482658 chr1:10539492 PEX14 -0.34 -6.9 -0.35 2.6e-11 Asthma; LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg20295408 chr7:1910781 MAD1L1 -0.44 -6.24 -0.32 1.32e-9 Bipolar disorder and schizophrenia; LUSC cis rs61931739 0.500 rs6488215 chr12:34434803 A/T cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC cis rs2573652 0.722 rs968412 chr15:100544512 C/G cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.94 -0.31 7.24e-9 Height; LUSC cis rs7582180 0.764 rs11693424 chr2:100925439 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.81 -0.35 4.56e-11 Glomerular filtration rate (creatinine); LUSC cis rs7824557 0.767 rs28507159 chr8:11166076 C/T cg21293242 chr8:11204541 TDH 0.32 5.91 0.31 8.42e-9 Retinal vascular caliber; LUSC cis rs1997103 0.954 rs7811098 chr7:55413012 A/G cg17469321 chr7:55412551 NA 0.65 10.53 0.5 1.45e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2486288 0.656 rs12911186 chr15:45551423 A/G cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.67 -0.5 4.42e-23 Glomerular filtration rate; LUSC cis rs59918340 0.764 rs4961338 chr8:142230192 C/T cg23750338 chr8:142222470 SLC45A4 -0.56 -10.95 -0.51 4.79e-24 Immature fraction of reticulocytes; LUSC cis rs6598955 0.543 rs3795689 chr1:26560366 C/G cg12744634 chr1:26560303 CCDC21 0.4 5.92 0.31 8.03e-9 Obesity-related traits; LUSC cis rs2777491 0.574 rs1757468 chr15:41743574 T/A cg18705301 chr15:41695430 NDUFAF1 -1.02 -20.84 -0.75 2.3e-62 Ulcerative colitis; LUSC cis rs9796 0.689 rs692153 chr15:41452681 C/T cg18705301 chr15:41695430 NDUFAF1 -0.47 -8.44 -0.42 1.01e-15 Menopause (age at onset); LUSC cis rs1256061 0.603 rs1256039 chr14:64738979 G/C cg23250157 chr14:64679961 SYNE2 0.32 5.7 0.3 2.68e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs73198271 0.740 rs1039911 chr8:8648206 G/A cg01851573 chr8:8652454 MFHAS1 0.54 8.86 0.44 4.92e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4494114 1.000 rs3790441 chr1:39352492 G/A cg25970120 chr1:39325951 RRAGC -0.39 -6.05 -0.31 3.81e-9 Blood protein levels; LUSC cis rs6977660 1.000 rs10275322 chr7:19821220 C/T cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg18876405 chr7:65276391 NA -0.57 -9.33 -0.45 1.56e-18 Aortic root size; LUSC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg16520312 chr17:43971471 MAPT;LOC100128977 -0.37 -6.41 -0.33 4.99e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.78 0.39 9.3e-14 Prudent dietary pattern; LUSC cis rs983392 0.709 rs7928895 chr11:59975165 G/A cg24026212 chr11:59952134 MS4A6A -0.36 -6.22 -0.32 1.53e-9 Alzheimer's disease (late onset); LUSC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.17 0.45 4.98e-18 Monocyte percentage of white cells; LUSC trans rs61931739 0.817 rs2203086 chr12:34232590 T/C cg26384229 chr12:38710491 ALG10B 0.53 8.49 0.42 7.1e-16 Morning vs. evening chronotype; LUSC cis rs1008375 0.931 rs4479701 chr4:17571496 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.87 0.31 1.04e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs75804782 0.521 rs55988884 chr2:239396930 G/A cg18131467 chr2:239335373 ASB1 -0.67 -6.23 -0.32 1.43e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs1912483 0.505 rs11079772 chr17:45393739 A/C cg08085267 chr17:45401833 C17orf57 0.59 8.59 0.43 3.34e-16 Coronary artery disease; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9300255 0.509 rs641760 chr12:123518866 T/C cg00376283 chr12:123451042 ABCB9 0.7 8.52 0.42 5.49e-16 Neutrophil percentage of white cells; LUSC cis rs752010 0.811 rs10749836 chr1:42086860 G/C cg06885757 chr1:42089581 HIVEP3 0.41 8.18 0.41 5.81e-15 Lupus nephritis in systemic lupus erythematosus; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg16656864 chr17:27718261 TAOK1 0.48 6.33 0.33 7.81e-10 Neuroticism; LUSC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg24399712 chr22:39784796 NA -0.54 -7.86 -0.4 5.25e-14 IgG glycosylation; LUSC trans rs7647973 0.677 rs11130211 chr3:49645209 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.63 -0.39 2.43e-13 Menarche (age at onset); LUSC cis rs593982 1.000 rs593982 chr11:65513107 T/C cg08755490 chr11:65554678 OVOL1 1.41 17.72 0.7 5.44e-50 Atopic dermatitis; LUSC cis rs894344 0.584 rs2028556 chr8:135648040 T/C cg27224718 chr8:135614730 ZFAT 0.35 5.68 0.3 2.98e-8 Systolic blood pressure; LUSC cis rs8062405 0.756 rs151301 chr16:28497059 T/A cg16576597 chr16:28551801 NUPR1 0.29 5.85 0.3 1.18e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg03929089 chr4:120376271 NA -0.77 -12.25 -0.56 9.36e-29 Height; LUSC cis rs11264799 0.603 rs12134075 chr1:157586516 C/T cg18268488 chr1:157545234 FCRL4 0.33 6.03 0.31 4.34e-9 IgA nephropathy; LUSC cis rs7189233 0.955 rs72801853 chr16:53516824 A/G cg09728985 chr16:53543985 NA -0.34 -6.05 -0.31 3.91e-9 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs10927875 1.000 rs3979179 chr1:16306846 A/G cg22431228 chr1:16359049 CLCNKA -0.44 -8.53 -0.42 5.02e-16 Dilated cardiomyopathy; LUSC cis rs9486715 0.758 rs9386528 chr6:96928514 G/A cg06623918 chr6:96969491 KIAA0776 -0.89 -14.35 -0.62 1.04e-36 Headache; LUSC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 5.92 0.31 7.79e-9 Personality dimensions; LUSC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.34 0.42 1.99e-15 Schizophrenia; LUSC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.7 -10.34 -0.49 6.33e-22 Chronic sinus infection; LUSC cis rs992157 0.735 rs13393821 chr2:219076742 C/G cg00012203 chr2:219082015 ARPC2 0.88 16.79 0.68 2.75e-46 Colorectal cancer; LUSC cis rs2880765 0.566 rs11630381 chr15:86012503 A/G cg10818794 chr15:86012489 AKAP13 -0.42 -6.55 -0.34 2.23e-10 Coronary artery disease; LUSC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg13683864 chr3:40499215 RPL14 -1.11 -21.81 -0.77 3.53e-66 Renal cell carcinoma; LUSC cis rs7605827 0.930 rs6431705 chr2:15599988 C/G cg19274914 chr2:15703543 NA -0.47 -9.15 -0.45 5.78e-18 Educational attainment (years of education); LUSC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg08917208 chr2:24149416 ATAD2B -0.52 -5.78 -0.3 1.75e-8 Lymphocyte counts; LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg07507251 chr3:52567010 NT5DC2 0.36 6.91 0.35 2.39e-11 Bipolar disorder; LUSC cis rs2455799 0.574 rs2470534 chr3:15701054 C/G cg16303742 chr3:15540471 COLQ 0.33 6.57 0.34 1.96e-10 Mean platelet volume; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg09177884 chr7:1199841 ZFAND2A -0.63 -9.35 -0.46 1.28e-18 Longevity;Endometriosis; LUSC cis rs3126085 0.935 rs4595369 chr1:152248193 G/A cg26876637 chr1:152193138 HRNR 0.46 6.33 0.33 8e-10 Atopic dermatitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03182158 chr8:125487804 RNF139 -0.49 -5.98 -0.31 5.59e-9 Bipolar disorder and schizophrenia; LUSC cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg00530320 chr1:46809349 NSUN4 0.54 8.63 0.43 2.48e-16 Menopause (age at onset); LUSC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg19230755 chr7:65878503 NA -0.43 -5.96 -0.31 6.34e-9 Aortic root size; LUSC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg06640241 chr16:89574553 SPG7 -0.86 -15.6 -0.65 1.33e-41 Multiple myeloma (IgH translocation); LUSC cis rs9811920 0.809 rs796976 chr3:99621002 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 6.6 0.34 1.63e-10 Axial length; LUSC trans rs62458065 0.513 rs787216 chr7:32578891 G/A cg00845942 chr12:64062724 DPY19L2 -0.62 -7.97 -0.4 2.45e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2637266 0.655 rs846584 chr10:78495419 G/A cg18941641 chr10:78392320 NA 0.38 6.91 0.35 2.49e-11 Pulmonary function; LUSC cis rs950169 0.580 rs11633762 chr15:85187152 T/C cg17507749 chr15:85114479 UBE2QP1 0.56 7.18 0.37 4.53e-12 Schizophrenia; LUSC cis rs17604090 0.938 rs68158127 chr7:29684698 A/G cg19413766 chr7:29689036 LOC646762 -0.57 -6.66 -0.34 1.1e-10 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs713477 0.967 rs4901568 chr14:55912789 T/A cg13175173 chr14:55914753 NA -0.32 -6.79 -0.35 5.12e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg26314531 chr2:26401878 FAM59B 0.68 8.82 0.43 6.6e-17 Gut microbiome composition (summer); LUSC cis rs9309473 0.500 rs10189578 chr2:73728609 C/A cg20560298 chr2:73613845 ALMS1 -0.46 -7.25 -0.37 2.91e-12 Metabolite levels; LUSC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg20135002 chr11:47629003 NA 0.51 7.99 0.4 2.26e-14 Subjective well-being; LUSC cis rs72781680 0.611 rs6720131 chr2:24364736 C/T cg20701182 chr2:24300061 SF3B14 0.84 10.43 0.5 3.11e-22 Lymphocyte counts; LUSC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.23 0.52 4.8e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9549367 0.789 rs12866090 chr13:113869410 G/A cg00898013 chr13:113819073 PROZ -0.6 -8.55 -0.42 4.63e-16 Platelet distribution width; LUSC cis rs9443645 0.588 rs1415310 chr6:79822314 C/T cg05283184 chr6:79620031 NA -0.46 -8.69 -0.43 1.6e-16 Intelligence (multi-trait analysis); LUSC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg03684893 chr10:554711 DIP2C 0.36 6.5 0.34 2.96e-10 Psychosis in Alzheimer's disease; LUSC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg25039879 chr17:56429692 SUPT4H1 0.66 8.86 0.44 4.86e-17 Cognitive test performance; LUSC cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg06627628 chr2:24431161 ITSN2 -0.58 -7.15 -0.36 5.66e-12 Lymphocyte counts; LUSC cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -7.9 -0.4 4.17e-14 Glomerular filtration rate (creatinine); LUSC trans rs11098499 0.863 rs12498539 chr4:120468370 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.83 0.35 3.91e-11 Corneal astigmatism; LUSC cis rs6456156 0.565 rs12529959 chr6:167469292 T/C cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs1048238 0.506 rs6668183 chr1:16173814 G/C cg21385522 chr1:16154831 NA 0.56 8.89 0.44 3.78e-17 Systolic blood pressure; LUSC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg02187348 chr16:89574699 SPG7 0.49 7.55 0.38 4.1e-13 Multiple myeloma (IgH translocation); LUSC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg18876405 chr7:65276391 NA 0.75 13.4 0.59 4.65e-33 Aortic root size; LUSC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg10523679 chr1:76189770 ACADM -0.86 -11.29 -0.53 2.9e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8063160 0.740 rs71396950 chr16:89726550 G/A cg07984980 chr16:89898383 SPIRE2 0.87 6.78 0.35 5.44e-11 Red vs non-red hair color;Light vs. dark hair color;Brown vs. non-brown hair color; LUSC cis rs2486288 0.656 rs1060896 chr15:45554267 C/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.89 -0.4 4.34e-14 Glomerular filtration rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20703375 chr7:98957328 ARPC1A 0.44 6.23 0.32 1.4e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg18230493 chr5:56204884 C5orf35 -0.93 -13.74 -0.6 2.25e-34 Initial pursuit acceleration; LUSC cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 7.46 0.38 7.51e-13 Colorectal cancer; LUSC cis rs6977660 1.000 rs10279601 chr7:19822171 G/A cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs2276314 0.857 rs28540805 chr18:33641975 T/G cg19628046 chr18:33552617 C18orf21 0.5 6.05 0.31 3.79e-9 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs2898290 0.617 rs13278965 chr8:11466745 A/T cg15556689 chr8:8085844 FLJ10661 0.54 8.33 0.41 2.19e-15 Systolic blood pressure; LUSC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg10802521 chr3:52805072 NEK4 -0.53 -8.53 -0.42 5.26e-16 Bipolar disorder; LUSC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg11062466 chr8:58055876 NA 0.5 6.43 0.33 4.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg05110241 chr16:68378359 PRMT7 -0.57 -6.55 -0.34 2.11e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs11098499 0.754 rs2036860 chr4:120248934 A/G cg25214090 chr10:38739885 LOC399744 0.44 6.63 0.34 1.38e-10 Corneal astigmatism; LUSC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg27398817 chr8:82754497 SNX16 -0.51 -6.79 -0.35 5.01e-11 Diastolic blood pressure; LUSC trans rs890100 0.768 rs13410457 chr2:56695046 A/G cg01657744 chr10:88471748 LDB3 0.44 6.05 0.31 3.99e-9 Gut microbiome composition (summer); LUSC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg17330251 chr7:94953956 PON1 -0.37 -5.99 -0.31 5.43e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.29 -5.83 -0.3 1.3e-8 Cognitive function; LUSC cis rs4363385 0.530 rs58298199 chr1:152908814 A/C cg00922841 chr1:152955080 SPRR1A -0.38 -6.28 -0.32 1.08e-9 Inflammatory skin disease; LUSC cis rs10754283 0.871 rs72712569 chr1:90125657 G/C cg21401794 chr1:90099060 LRRC8C -0.55 -7.58 -0.38 3.43e-13 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs10992471 0.605 rs7872375 chr9:95064843 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.46 -0.33 3.63e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg09877947 chr5:131593287 PDLIM4 -0.46 -7.06 -0.36 9.71e-12 Breast cancer; LUSC trans rs417096 0.895 rs57021432 chr6:39734042 T/C cg17457912 chr17:1617102 C17orf91 -0.33 -6.38 -0.33 5.84e-10 Hypospadias; LUSC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.44 0.5 2.79e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg21926612 chr6:163149169 PACRG;PARK2 1.2 16.31 0.67 2.22e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs983392 0.805 rs7926354 chr11:59962189 G/A cg24026212 chr11:59952134 MS4A6A -0.38 -6.58 -0.34 1.86e-10 Alzheimer's disease (late onset); LUSC trans rs11992162 0.573 rs61468577 chr8:11784925 A/C cg27411982 chr8:10470053 RP1L1 -0.41 -6.21 -0.32 1.62e-9 Monocyte count; LUSC cis rs7072216 0.763 rs4475861 chr10:100164989 C/T cg26618903 chr10:100175079 PYROXD2 -0.46 -8.6 -0.43 3.19e-16 Metabolite levels; LUSC cis rs28595532 1.000 rs41455648 chr4:119718030 A/G cg21605333 chr4:119757512 SEC24D 1.27 10.11 0.48 3.98e-21 Cannabis dependence symptom count; LUSC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg17724175 chr1:150552817 MCL1 0.37 6.53 0.34 2.49e-10 Tonsillectomy; LUSC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg16624210 chr5:671434 TPPP 0.49 6.16 0.32 2.14e-9 Obesity-related traits; LUSC cis rs497273 0.530 rs2701185 chr12:121352974 A/G cg02403541 chr12:121454288 C12orf43 0.41 5.84 0.3 1.26e-8 Systemic lupus erythematosus; LUSC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg13319975 chr6:146136371 FBXO30 -0.71 -11.44 -0.53 8.48e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs11997175 0.574 rs12156280 chr8:33650277 C/T ch.8.33884649F chr8:33765107 NA 0.52 8.46 0.42 8.64e-16 Body mass index; LUSC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg18225595 chr11:63971243 STIP1 -0.43 -7.07 -0.36 9.2e-12 Platelet count; LUSC cis rs11785693 0.865 rs11784227 chr8:4970485 A/C cg26367366 chr8:4980734 NA 0.84 9.14 0.45 6.24e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg10360139 chr7:1886902 MAD1L1 -0.39 -6.06 -0.31 3.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs6901004 0.596 rs411604 chr6:111565847 A/G cg15721981 chr6:111408429 SLC16A10 -0.55 -7.88 -0.4 4.61e-14 Blood metabolite levels; LUSC trans rs1908814 0.516 rs7825529 chr8:11794444 C/T cg08975724 chr8:8085496 FLJ10661 0.48 7.04 0.36 1.1e-11 Neuroticism; LUSC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg02782426 chr3:40428986 ENTPD3 0.33 6.28 0.32 1.05e-9 Renal cell carcinoma; LUSC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg22823121 chr1:150693482 HORMAD1 0.62 9.47 0.46 5.19e-19 Tonsillectomy; LUSC cis rs7824557 0.614 rs2736286 chr8:11227104 A/G cg21775007 chr8:11205619 TDH -0.72 -12.12 -0.55 2.91e-28 Retinal vascular caliber; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg13472656 chr22:25960710 ADRBK2 -0.48 -5.96 -0.31 6.29e-9 Height; LUSC cis rs751728 0.965 rs9394168 chr6:33759701 T/A cg25922239 chr6:33757077 LEMD2 0.53 7.87 0.4 4.93e-14 Crohn's disease; LUSC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg27170947 chr2:26402098 FAM59B -0.63 -9.15 -0.45 5.98e-18 Gut microbiome composition (summer); LUSC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.33 -0.33 7.76e-10 Personality dimensions; LUSC cis rs568617 1.000 rs641018 chr11:65655393 G/C cg04055107 chr11:65626734 MUS81;CFL1 0.5 6.15 0.32 2.15e-9 Crohn's disease; LUSC cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.38 -5.92 -0.31 8.15e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11971779 0.941 rs7802779 chr7:139122579 G/T cg07862535 chr7:139043722 LUC7L2 0.73 8.73 0.43 1.24e-16 Diisocyanate-induced asthma; LUSC cis rs1577917 0.958 rs36035797 chr6:86562880 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs3782089 0.744 rs11545200 chr11:65319751 G/A cg11802864 chr11:65308245 LTBP3 0.84 5.81 0.3 1.42e-8 Height; LUSC cis rs1023500 0.551 rs61665536 chr22:42512613 A/G cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Schizophrenia; LUSC cis rs981844 0.712 rs3925717 chr4:154750917 C/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.3 -0.33 9.19e-10 Response to statins (LDL cholesterol change); LUSC cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg13010199 chr12:38710504 ALG10B 0.48 7.49 0.38 6.31e-13 Morning vs. evening chronotype; LUSC cis rs2742417 1.000 rs2742386 chr3:45756310 A/C cg09608765 chr3:45636137 LIMD1 -0.39 -7.81 -0.39 7.4e-14 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 13.47 0.59 2.39e-33 Platelet count; LUSC cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg17845761 chr1:175162550 KIAA0040 -0.33 -6.21 -0.32 1.56e-9 Alcohol dependence; LUSC cis rs62400317 0.859 rs12193030 chr6:45175210 G/A cg18551225 chr6:44695536 NA -0.45 -7.38 -0.37 1.27e-12 Total body bone mineral density; LUSC trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg03929089 chr4:120376271 NA -1.01 -17.91 -0.7 9.77e-51 Height; LUSC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.54 -0.46 3.12e-19 Intelligence (multi-trait analysis); LUSC cis rs17828380 0.920 rs71393133 chr15:63459591 C/T cg05507819 chr15:63340323 TPM1 -0.75 -6.16 -0.32 2.1e-9 Social communication problems; LUSC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg24642844 chr7:1081250 C7orf50 -0.71 -9.88 -0.48 2.22e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1023500 0.573 rs133377 chr22:42466950 C/T cg05082376 chr22:42548792 NA -0.43 -6.48 -0.33 3.36e-10 Schizophrenia; LUSC cis rs6964587 1.000 rs3753109 chr7:91630001 G/C cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.75e-18 Breast cancer; LUSC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 1.000 rs9611565 chr22:41767486 T/C cg03806693 chr22:41940476 POLR3H -0.79 -11.59 -0.54 2.37e-26 Vitiligo; LUSC cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 6.01 0.31 4.91e-9 Rheumatoid arthritis; LUSC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg22834771 chr12:69754056 YEATS4 -0.43 -5.66 -0.3 3.25e-8 Response to diuretic therapy; LUSC cis rs4604732 0.588 rs4356092 chr1:247632668 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.41 6.46 0.33 3.71e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC trans rs4794665 0.874 rs1467246 chr17:54845117 C/T cg18503679 chr3:21792543 ZNF385D 0.36 5.96 0.31 6.48e-9 Height; LUSC cis rs11039100 1.000 rs4474469 chr11:5828849 T/C cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs12043259 0.502 rs6593907 chr1:204746302 A/G cg06849515 chr4:13549607 LOC285548 0.54 5.95 0.31 6.81e-9 Addiction; LUSC cis rs72781680 0.898 rs12622290 chr2:23979894 C/G cg08917208 chr2:24149416 ATAD2B 0.87 9.69 0.47 9.99e-20 Lymphocyte counts; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06494227 chr22:30752758 CCDC157;SF3A1 -0.51 -6.47 -0.33 3.54e-10 Bipolar disorder and schizophrenia; LUSC trans rs747782 0.528 rs10838881 chr11:48387275 T/C cg15704280 chr7:45808275 SEPT13 0.68 6.43 0.33 4.36e-10 Intraocular pressure; LUSC cis rs6754311 0.731 rs1470457 chr2:136581848 A/G cg07169764 chr2:136633963 MCM6 0.76 10.14 0.49 2.94e-21 Mosquito bite size; LUSC cis rs713477 0.817 rs55868790 chr14:55913275 T/C cg13175173 chr14:55914753 NA -0.3 -6.21 -0.32 1.57e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs2309752 1 rs2309752 chr2:100762169 T/A cg07810366 chr2:100720526 AFF3 -0.51 -8.86 -0.44 4.76e-17 Intelligence (multi-trait analysis); LUSC cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg22782873 chr19:19639568 YJEFN3 -0.47 -5.85 -0.3 1.17e-8 Bipolar disorder; LUSC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg21918786 chr6:109611834 NA -0.41 -7.3 -0.37 2.14e-12 Reticulocyte fraction of red cells; LUSC cis rs1113500 0.933 rs11185256 chr1:108633957 C/T cg11967332 chr1:108735228 SLC25A24 0.39 5.92 0.31 7.86e-9 Growth-regulated protein alpha levels; LUSC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg06634786 chr22:41940651 POLR3H 0.49 5.75 0.3 2.01e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg06873352 chr17:61820015 STRADA -0.73 -12.92 -0.58 2.91e-31 Prudent dietary pattern; LUSC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg24838063 chr12:130822603 PIWIL1 0.69 10.79 0.51 1.69e-23 Menopause (age at onset); LUSC cis rs1949733 0.656 rs6845969 chr4:8402465 A/T cg11789530 chr4:8429930 ACOX3 0.55 8.82 0.43 6.42e-17 Response to antineoplastic agents; LUSC cis rs7592578 0.771 rs12053190 chr2:191383348 A/G cg10560079 chr2:191398806 TMEM194B -0.76 -9.52 -0.46 3.75e-19 Diastolic blood pressure; LUSC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg03609598 chr5:56110824 MAP3K1 -0.41 -6.1 -0.32 2.85e-9 Initial pursuit acceleration; LUSC cis rs2425143 0.558 rs7274724 chr20:34539466 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.68 -0.3 2.89e-8 Blood protein levels; LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg01171360 chr6:293285 DUSP22 -0.51 -7.68 -0.39 1.74e-13 Menopause (age at onset); LUSC cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg19539972 chr4:7069911 GRPEL1 0.73 9.0 0.44 1.72e-17 Monocyte percentage of white cells; LUSC cis rs870825 0.616 rs72703531 chr4:185611092 C/T cg04058563 chr4:185651563 MLF1IP 0.86 12.54 0.57 7.8e-30 Blood protein levels; LUSC cis rs2115630 1.000 rs2115630 chr15:85364516 C/T cg17173187 chr15:85201210 NMB -0.28 -5.73 -0.3 2.2e-8 P wave terminal force; LUSC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC trans rs2144940 0.920 rs2567617 chr20:23049547 G/A cg01465325 chr10:50747588 ERCC6 0.79 6.06 0.31 3.78e-9 Venous thromboembolism; LUSC cis rs477692 0.837 rs543454 chr10:131420536 T/C cg11019008 chr10:131425282 MGMT 0.4 6.2 0.32 1.68e-9 Response to temozolomide; LUSC trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg03929089 chr4:120376271 NA 0.61 6.6 0.34 1.65e-10 Axial length; LUSC cis rs10080237 0.564 rs2490230 chr6:80812464 G/A cg08355045 chr6:80787529 NA 0.55 9.8 0.47 4.25e-20 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; LUSC cis rs2540226 0.935 rs3732121 chr2:39988804 C/T cg23576258 chr2:39999331 THUMPD2 0.35 5.85 0.3 1.19e-8 Personality dimensions; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg21252483 chr19:49399788 TULP2 -0.48 -6.77 -0.35 5.81e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg23711669 chr6:146136114 FBXO30 -0.83 -15.28 -0.64 2.37e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs1348850 0.846 rs4893962 chr2:178421106 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 6.99 0.36 1.54e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg24642439 chr20:33292090 TP53INP2 0.74 12.24 0.56 1e-28 Coronary artery disease; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg22903657 chr4:1355424 KIAA1530 -0.39 -6.55 -0.34 2.13e-10 Longevity; LUSC cis rs12410462 0.681 rs115959512 chr1:227599578 T/C cg23173402 chr1:227635558 NA 0.71 7.32 0.37 1.85e-12 Major depressive disorder; LUSC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg13390004 chr1:15929781 NA 0.41 6.75 0.35 6.57e-11 Systolic blood pressure; LUSC cis rs8027181 1.000 rs2162269 chr15:73090262 C/T cg25632853 chr15:73088954 NA 0.34 6.61 0.34 1.55e-10 Triglyceride levels; LUSC cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg02527881 chr3:46936655 PTH1R -0.39 -6.87 -0.35 3.2e-11 Colorectal cancer; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7589342 0.536 rs17201484 chr2:106394809 C/G cg09152813 chr2:106391379 NCK2 -0.39 -6.26 -0.32 1.16e-9 Addiction; LUSC cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg16346588 chr10:242978 ZMYND11 -0.45 -6.14 -0.32 2.31e-9 Psychosis in Alzheimer's disease; LUSC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg05890377 chr2:74357713 NA 0.72 13.68 0.6 3.83e-34 Gestational age at birth (maternal effect); LUSC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.05e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6964587 0.869 rs7812219 chr7:91545727 C/T cg22709100 chr7:91322751 NA -0.39 -5.72 -0.3 2.42e-8 Breast cancer; LUSC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg20503657 chr10:835505 NA 0.97 13.55 0.6 1.23e-33 Eosinophil percentage of granulocytes; LUSC cis rs6964587 0.967 rs12671991 chr7:91559481 T/C cg22709100 chr7:91322751 NA -0.4 -5.78 -0.3 1.67e-8 Breast cancer; LUSC trans rs7980799 0.654 rs10844618 chr12:33625010 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.35 -0.33 7.23e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg04450456 chr4:17643702 FAM184B 0.37 6.34 0.33 7.37e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg11752832 chr7:134001865 SLC35B4 0.54 8.12 0.41 9.29e-15 Mean platelet volume; LUSC cis rs56283067 0.578 rs10948233 chr6:45364096 A/T cg18551225 chr6:44695536 NA 0.43 6.56 0.34 2.05e-10 Total body bone mineral density; LUSC cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs4409675 0.576 rs6598912 chr1:28233289 C/T cg23691781 chr1:28212827 C1orf38 0.3 7.34 0.37 1.67e-12 Corneal astigmatism; LUSC cis rs11031096 0.727 rs2268168 chr11:4142069 C/T cg08557956 chr11:4115526 RRM1 -0.42 -5.7 -0.3 2.62e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg04944784 chr2:26401820 FAM59B -0.7 -9.79 -0.47 4.49e-20 Gut microbiome composition (summer); LUSC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg13319975 chr6:146136371 FBXO30 0.53 7.84 0.39 6.04e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg16405210 chr4:1374714 KIAA1530 0.58 8.82 0.43 6.51e-17 Obesity-related traits; LUSC cis rs10751667 0.961 rs10902263 chr11:992691 A/C cg06064525 chr11:970664 AP2A2 0.35 6.99 0.36 1.46e-11 Alzheimer's disease (late onset); LUSC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs3824867 0.920 rs3740685 chr11:47468791 C/T cg20307385 chr11:47447363 PSMC3 0.64 9.37 0.46 1.13e-18 Mean corpuscular hemoglobin; LUSC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.62 8.06 0.4 1.4e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9457247 0.534 rs4710149 chr6:167386346 T/C cg23791538 chr6:167370224 RNASET2 0.5 8.4 0.42 1.34e-15 Crohn's disease; LUSC cis rs2235649 0.746 rs35104579 chr16:1848657 A/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.46 -6.12 -0.32 2.65e-9 Blood metabolite levels; LUSC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.56 -0.34 2.06e-10 Schizophrenia; LUSC cis rs8078723 1.000 rs4795415 chr17:38157995 C/T cg17467752 chr17:38218738 THRA 0.77 12.47 0.56 1.47e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -6.42 -0.33 4.67e-10 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg25456477 chr12:86230367 RASSF9 0.43 7.73 0.39 1.25e-13 Major depressive disorder; LUSC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg06238570 chr21:40685208 BRWD1 -0.58 -9.13 -0.45 6.88e-18 Menarche (age at onset); LUSC cis rs16976116 0.901 rs3759861 chr15:55473192 C/T cg11288833 chr15:55489084 RSL24D1 0.48 5.77 0.3 1.77e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs300703 0.872 rs428697 chr2:213302 G/A cg21211680 chr2:198530 NA 0.7 7.27 0.37 2.54e-12 Blood protein levels; LUSC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11890956 chr21:40555474 PSMG1 1.01 18.96 0.72 6.39e-55 Cognitive function; LUSC cis rs11190604 1.000 rs11190552 chr10:102206607 G/A cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12776158 0.901 rs57028689 chr10:71216345 G/A cg12610070 chr10:71211762 TSPAN15 -0.46 -6.05 -0.31 3.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg08754478 chr10:133766260 PPP2R2D -0.62 -7.79 -0.39 8.39e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs1506636 1.000 rs2429617 chr7:123418027 A/G cg03229431 chr7:123269106 ASB15 0.65 10.68 0.5 4.29e-23 Plateletcrit;Platelet count; LUSC cis rs208520 0.690 rs4618506 chr6:66756889 A/C cg07460842 chr6:66804631 NA -1.04 -16.36 -0.67 1.35e-44 Exhaled nitric oxide output; LUSC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg06636001 chr8:8085503 FLJ10661 0.54 8.26 0.41 3.48e-15 Myopia (pathological); LUSC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg03806693 chr22:41940476 POLR3H 0.99 13.72 0.6 2.7200000000000002e-34 Vitiligo; LUSC cis rs8044995 0.563 rs73613962 chr16:68361974 T/G cg09835421 chr16:68378352 PRMT7 -0.75 -7.87 -0.4 5.06e-14 Schizophrenia; LUSC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg11812906 chr14:75593930 NEK9 -0.63 -10.43 -0.5 3.18e-22 Height; LUSC cis rs4969178 0.965 rs12451715 chr17:76397334 A/C cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs7615952 0.932 rs3811679 chr3:125648283 A/G cg02807482 chr3:125708958 NA -0.49 -5.73 -0.3 2.21e-8 Blood pressure (smoking interaction); LUSC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.56 7.95 0.4 2.88e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6542838 0.704 rs12474283 chr2:99527310 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.02 -0.36 1.28e-11 Fear of minor pain; LUSC cis rs12618769 0.652 rs1139829 chr2:99225168 C/T cg10123293 chr2:99228465 UNC50 0.47 7.7 0.39 1.59e-13 Bipolar disorder; LUSC cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg00012203 chr2:219082015 ARPC2 -0.77 -13.72 -0.6 2.88e-34 Colorectal cancer; LUSC cis rs9660992 0.710 rs1172138 chr1:205246019 G/A cg21545522 chr1:205238299 TMCC2 0.51 9.46 0.46 5.7e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs11597390 0.867 rs11596837 chr10:101850079 C/A cg02250046 chr10:101825185 CPN1 -0.34 -6.06 -0.31 3.7e-9 Liver enzyme levels; LUSC cis rs11190604 1.000 rs2489047 chr10:102347028 A/G cg16342193 chr10:102329863 NA -0.34 -6.12 -0.32 2.68e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs929354 1.000 rs1182414 chr7:157058363 G/A cg17757837 chr7:157058334 UBE3C -0.93 -15.88 -0.66 1.09e-42 Body mass index; LUSC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg20283391 chr11:68216788 NA -0.59 -8.34 -0.41 2.03e-15 Total body bone mineral density; LUSC cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg23583168 chr7:148888333 NA -0.8 -13.29 -0.59 1.19e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1044826 0.642 rs4683464 chr3:139196961 C/T cg15131784 chr3:139108705 COPB2 0.37 5.78 0.3 1.69e-8 Obesity-related traits; LUSC cis rs72781680 0.898 rs72798049 chr2:23958002 C/G cg20701182 chr2:24300061 SF3B14 0.55 5.85 0.3 1.2e-8 Lymphocyte counts; LUSC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg25838465 chr1:92012736 NA -0.52 -7.68 -0.39 1.81e-13 Eosinophil percentage of white cells; LUSC cis rs9902453 1.000 rs57411618 chr17:28273052 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.32 0.45 1.64e-18 Coffee consumption (cups per day); LUSC trans rs800082 0.698 rs800073 chr3:144347599 G/A cg24215973 chr2:240111563 HDAC4 -0.7 -10.34 -0.49 6.26e-22 Smoking behavior; LUSC cis rs4478137 0.931 rs56233753 chr4:164249023 A/G cg06758707 chr4:164254230 NPY1R 0.62 9.8 0.47 4.19e-20 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg18230493 chr5:56204884 C5orf35 -0.86 -12.9 -0.58 3.52e-31 Initial pursuit acceleration; LUSC cis rs240764 0.782 rs239231 chr6:101105022 G/A cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs7598759 0.679 rs6437019 chr2:232327707 T/C cg19187155 chr2:232395269 NMUR1 0.49 7.16 0.36 5.13e-12 Noise-induced hearing loss; LUSC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg04166393 chr7:2884313 GNA12 0.42 5.91 0.31 8.66e-9 Height; LUSC cis rs6977660 0.714 rs6970798 chr7:19816741 G/C cg05791153 chr7:19748676 TWISTNB 0.68 7.22 0.37 3.49e-12 Thyroid stimulating hormone; LUSC cis rs3772130 0.583 rs9819530 chr3:121387784 T/G cg20356878 chr3:121714668 ILDR1 0.55 8.86 0.44 4.95e-17 Cognitive performance; LUSC cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.52 -0.42 5.68e-16 Axial length; LUSC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg24578937 chr1:2090814 PRKCZ -0.41 -9.04 -0.44 1.32e-17 Height; LUSC cis rs11098499 0.909 rs9994810 chr4:120381590 A/G cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.54e-25 Corneal astigmatism; LUSC cis rs41271951 0.512 rs41266632 chr1:151042980 C/T cg11822372 chr1:151115635 SEMA6C -0.78 -7.18 -0.37 4.51e-12 Blood protein levels; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.3 6.55 0.34 2.18e-10 Electroencephalogram traits; LUSC cis rs7580658 0.724 rs12623948 chr2:128001342 G/A cg09760422 chr2:128146352 NA -0.31 -6.88 -0.35 2.88e-11 Protein C levels; LUSC cis rs10140922 0.966 rs10135277 chr14:35823231 A/G cg07166546 chr14:35805898 NA 0.26 6.34 0.33 7.3e-10 Hip circumference adjusted for BMI; LUSC trans rs8072100 0.840 rs9895746 chr17:45479099 C/A cg03886242 chr7:26192032 NFE2L3 -0.39 -6.36 -0.33 6.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg08270630 chr22:50330655 NA -0.44 -6.61 -0.34 1.48e-10 Schizophrenia; LUSC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg15921436 chr17:44337874 NA -0.71 -10.88 -0.51 8.17e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9517320 1.000 rs9517320 chr13:99126303 G/T cg07423050 chr13:99094983 FARP1 -0.36 -7.0 -0.36 1.43e-11 Longevity; LUSC cis rs1775715 0.737 rs2808090 chr10:32143208 A/C cg18675610 chr10:32216311 ARHGAP12 0.31 6.67 0.34 1.05e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4072705 0.646 rs4838187 chr9:127242076 G/C cg13476313 chr9:127244764 NR5A1 0.34 6.53 0.34 2.43e-10 Menarche (age at onset); LUSC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.89 0.4 4.49e-14 Melanoma; LUSC cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC trans rs17780086 0.527 rs17182651 chr17:30547537 G/A cg27661571 chr11:113659931 NA -0.63 -6.11 -0.32 2.73e-9 Height; LUSC cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg14689365 chr7:158441557 NCAPG2 -0.46 -6.33 -0.33 8.02e-10 Height; LUSC trans rs1814175 0.645 rs28634872 chr11:50042175 T/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 14.4 0.62 6.36e-37 Platelet count; LUSC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.87 0.35 3.2e-11 Initial pursuit acceleration; LUSC cis rs6785206 0.527 rs9844706 chr3:128380781 G/A cg16766828 chr3:128327626 NA -0.61 -7.23 -0.37 3.27e-12 Lymphocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06112727 chr8:22102711 POLR3D;MIR320A 0.49 6.81 0.35 4.44e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7843479 1.000 rs1032094 chr8:21820479 A/T cg10573190 chr2:85843190 USP39 -0.43 -6.13 -0.32 2.54e-9 Mean corpuscular volume; LUSC cis rs1113500 0.862 rs2336128 chr1:108640739 G/T cg11967332 chr1:108735228 SLC25A24 0.39 5.92 0.31 7.99e-9 Growth-regulated protein alpha levels; LUSC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg02018176 chr4:1364513 KIAA1530 0.5 8.54 0.42 4.76e-16 Obesity-related traits; LUSC cis rs6121246 0.567 rs6060297 chr20:30198560 A/G cg21427119 chr20:30132790 HM13 -0.44 -6.3 -0.33 9.21e-10 Mean corpuscular hemoglobin; LUSC cis rs6940638 0.688 rs9348750 chr6:27057945 T/G cg05738196 chr6:26577821 NA -0.47 -6.68 -0.34 9.71e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg11764359 chr7:65958608 NA -0.79 -13.02 -0.58 1.31e-31 Aortic root size; LUSC cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg27432699 chr2:27873401 GPN1 -0.59 -8.82 -0.43 6.57e-17 Total body bone mineral density; LUSC cis rs11650494 0.908 rs9891264 chr17:47407342 T/A cg08112188 chr17:47440006 ZNF652 1.15 10.51 0.5 1.61e-22 Prostate cancer; LUSC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg21856205 chr7:94953877 PON1 -0.35 -5.71 -0.3 2.51e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs4906332 1.000 rs35344594 chr14:103955792 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -7.16 -0.36 5.08e-12 Coronary artery disease; LUSC cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg13535736 chr9:111863775 C9orf5 -0.42 -6.84 -0.35 3.78e-11 Menarche (age at onset); LUSC trans rs561341 1.000 rs8064843 chr17:30245744 A/G cg27661571 chr11:113659931 NA -0.55 -6.51 -0.34 2.7e-10 Hip circumference adjusted for BMI; LUSC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg05234568 chr11:5960015 NA -0.65 -9.02 -0.44 1.53e-17 DNA methylation (variation); LUSC cis rs8064299 0.967 rs880827 chr17:72767435 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.65 -11.31 -0.53 2.44e-25 Monocyte count; LUSC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg17507749 chr15:85114479 UBE2QP1 0.69 8.7 0.43 1.56e-16 Schizophrenia; LUSC cis rs11785693 0.862 rs62491191 chr8:4993460 G/A cg26367366 chr8:4980734 NA 0.77 9.11 0.45 7.7e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg16339924 chr4:17578868 LAP3 0.62 9.71 0.47 8.61e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2652822 0.935 rs7162825 chr15:63439186 A/G cg02713581 chr15:63449717 RPS27L -0.39 -5.88 -0.31 9.83e-9 Metabolic traits; LUSC cis rs8062405 1.000 rs4451951 chr16:28836205 T/C cg09754948 chr16:28834200 ATXN2L 0.44 6.46 0.33 3.73e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.1 -0.36 7.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2236918 0.710 rs1776159 chr1:242018583 C/G cg17736920 chr1:242011382 EXO1 0.43 6.81 0.35 4.47e-11 Menopause (age at onset); LUSC cis rs41271473 1.000 rs11578216 chr1:228880098 A/T cg16512390 chr1:228756714 NA -0.48 -5.84 -0.3 1.21e-8 Chronic lymphocytic leukemia; LUSC cis rs11696845 0.787 rs13043441 chr20:43364308 A/G cg25301532 chr20:43378953 KCNK15 0.34 6.2 0.32 1.66e-9 Obesity-related traits; LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg24101359 chr6:42928495 GNMT 0.39 6.41 0.33 5.09e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3820928 0.967 rs4675114 chr2:227768362 C/T cg11843606 chr2:227700838 RHBDD1 -0.52 -7.66 -0.39 2.06e-13 Pulmonary function; LUSC cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.42 0.64 6.71e-41 Bladder cancer; LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 14.32 0.62 1.4e-36 Platelet count; LUSC cis rs6961069 0.585 rs10216184 chr7:80262830 A/G cg04458919 chr7:80252533 CD36 -0.41 -7.16 -0.36 5.11e-12 Platelet count; LUSC cis rs675828 1.000 rs675828 chr13:103350733 A/G cg19359983 chr13:103346900 C13orf39 0.34 5.82 0.3 1.36e-8 Borderline personality disorder; LUSC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg11663144 chr21:46675770 NA 0.41 7.21 0.37 3.68e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs61931739 0.500 rs7489132 chr12:34539712 C/T cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs477692 1.000 rs522891 chr10:131430916 T/C cg05714579 chr10:131428358 MGMT -0.51 -7.47 -0.38 7.2e-13 Response to temozolomide; LUSC cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg20476274 chr7:133979776 SLC35B4 -0.81 -14.39 -0.62 7.29e-37 Mean platelet volume; LUSC cis rs7818345 0.637 rs4599829 chr8:19358434 G/A cg01280390 chr8:19363452 CSGALNACT1 0.31 5.86 0.31 1.12e-8 Language performance in older adults (adjusted for episodic memory); LUSC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg14298792 chr15:30685198 CHRFAM7A 0.48 5.99 0.31 5.47e-9 Huntington's disease progression; LUSC cis rs10911363 0.592 rs10797886 chr1:183479090 T/C cg09173681 chr1:183549694 NCF2 0.66 12.21 0.56 1.38e-28 Systemic lupus erythematosus; LUSC cis rs1044826 0.692 rs188420 chr3:139233865 G/A cg00490450 chr3:139108681 COPB2 -0.46 -7.05 -0.36 1.06e-11 Obesity-related traits; LUSC cis rs72781680 1.000 rs17712391 chr2:24245659 C/T cg08917208 chr2:24149416 ATAD2B 0.98 10.23 0.49 1.51e-21 Lymphocyte counts; LUSC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg22903471 chr2:27725779 GCKR -0.41 -7.09 -0.36 8.05e-12 Total body bone mineral density; LUSC cis rs79349575 0.783 rs4793991 chr17:47001801 A/G cg22482690 chr17:47019901 SNF8 0.39 7.38 0.37 1.3e-12 Type 2 diabetes; LUSC cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs56283067 0.578 rs1321078 chr6:45368214 G/T cg20913747 chr6:44695427 NA -0.46 -6.69 -0.34 9.19e-11 Total body bone mineral density; LUSC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg14552801 chr7:65878734 NA 0.38 5.9 0.31 9e-9 Aortic root size; LUSC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg21433313 chr16:3507492 NAT15 -0.39 -6.15 -0.32 2.22e-9 Body mass index (adult); LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg06877462 chr1:205807181 PM20D1 0.5 8.99 0.44 1.94e-17 Menarche (age at onset); LUSC cis rs7246657 0.891 rs7253114 chr19:37988725 G/A cg23950597 chr19:37808831 NA -0.61 -7.32 -0.37 1.84e-12 Coronary artery calcification; LUSC cis rs7588746 0.868 rs12104649 chr2:201128832 C/T cg23649088 chr2:200775458 C2orf69 -0.51 -6.94 -0.36 2.01e-11 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs6545883 1.000 rs778758 chr2:61782161 T/C cg15711740 chr2:61764176 XPO1 -0.5 -7.99 -0.4 2.19e-14 Tuberculosis; LUSC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg21385522 chr1:16154831 NA 0.7 10.64 0.5 6.02e-23 Dilated cardiomyopathy; LUSC cis rs17655565 0.533 rs12825729 chr12:52706854 G/A cg08257133 chr12:52711352 KRT83 0.41 9.03 0.44 1.44e-17 Plasma amyloid beta peptide concentrations (ABx-42); LUSC cis rs7760949 0.852 rs9475801 chr6:13933115 G/A cg27413430 chr6:13925136 RNF182 0.61 8.94 0.44 2.64e-17 Mean corpuscular hemoglobin concentration; LUSC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg03929089 chr4:120376271 NA -0.49 -6.83 -0.35 4.06e-11 HDL cholesterol; LUSC cis rs9653442 0.527 rs10185059 chr2:100790172 C/T cg07810366 chr2:100720526 AFF3 -0.44 -7.5 -0.38 5.75e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1355223 0.583 rs1396881 chr11:34870506 G/T cg11058730 chr11:34937778 PDHX;APIP 0.67 10.8 0.51 1.61e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs68170813 0.617 rs117884147 chr7:107177593 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs1865760 0.929 rs2876693 chr6:25954434 C/G cg12310025 chr6:25882481 NA -0.35 -5.68 -0.3 2.93e-8 Height; LUSC cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.44 0.5 2.81e-22 Schizophrenia; LUSC cis rs17433780 1.000 rs17433780 chr1:89474818 C/T cg09516651 chr1:89888402 LOC400759 -0.48 -8.3 -0.41 2.6e-15 Carotid intima media thickness; LUSC cis rs57920188 0.568 rs10915665 chr1:4093717 G/T cg20703997 chr1:4087676 NA 0.59 8.24 0.41 3.85e-15 Interleukin-17 levels; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.37 0.56 3.34e-29 Prudent dietary pattern; LUSC cis rs6964587 1.000 rs34043009 chr7:91578447 T/C cg01689657 chr7:91764605 CYP51A1 -0.33 -6.06 -0.31 3.68e-9 Breast cancer; LUSC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg14829155 chr15:31115871 NA -0.56 -7.81 -0.39 7.44e-14 Huntington's disease progression; LUSC cis rs2625529 0.652 rs2929517 chr15:72332917 T/G cg16672083 chr15:72433130 SENP8 0.49 7.93 0.4 3.34e-14 Red blood cell count; LUSC cis rs13082711 0.834 rs2840088 chr3:27428371 G/A cg02860705 chr3:27208620 NA 0.5 8.64 0.43 2.34e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.66 -0.43 2.06e-16 Bipolar disorder; LUSC cis rs17604090 0.938 rs10253264 chr7:29692543 T/C cg19413766 chr7:29689036 LOC646762 -0.62 -7.46 -0.38 7.31e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs1595825 0.891 rs10497810 chr2:198895732 C/T cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs17401966 0.931 rs10492972 chr1:10353112 A/G cg19773385 chr1:10388646 KIF1B -0.58 -10.23 -0.49 1.56e-21 Hepatocellular carcinoma; LUSC cis rs2197308 0.619 rs4002730 chr12:37876400 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg20243544 chr17:37824526 PNMT 0.39 5.88 0.31 9.84e-9 Self-reported allergy; LUSC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.98 0.31 5.68e-9 Menopause (age at onset); LUSC cis rs155346 1.000 rs645898 chr5:139404852 C/T cg01090482 chr5:139365336 NRG2 -0.35 -5.71 -0.3 2.51e-8 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg17178900 chr1:205818956 PM20D1 0.84 14.54 0.62 1.97e-37 Menarche (age at onset); LUSC cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs11657217 1.000 rs8081537 chr17:77708264 A/G cg06901238 chr17:77706717 ENPP7 0.54 10.33 0.49 6.83e-22 Diastolic blood pressure response to hydrochlorothiazide in hypertension; LUSC cis rs7607369 0.791 rs12468043 chr2:219354197 C/A cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg14895029 chr7:2775587 GNA12 -0.4 -6.42 -0.33 4.55e-10 Height; LUSC cis rs7267979 1.000 rs6115182 chr20:25410259 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs231513 0.906 rs179586 chr17:41999094 T/C cg26893861 chr17:41843967 DUSP3 -0.59 -6.28 -0.33 1.02e-9 Cognitive function; LUSC cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg18196295 chr10:418757 DIP2C -0.44 -6.52 -0.34 2.61e-10 Psychosis in Alzheimer's disease; LUSC cis rs9325144 0.555 rs7960411 chr12:38703019 A/G cg13010199 chr12:38710504 ALG10B -0.5 -7.62 -0.38 2.65e-13 Morning vs. evening chronotype; LUSC cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg16322792 chr1:120165303 ZNF697 0.74 15.5 0.65 3.38e-41 Systemic lupus erythematosus; LUSC cis rs10740039 0.883 rs1442546 chr10:62409998 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.85 -0.35 3.61e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1163251 0.902 rs487081 chr1:120217389 G/A cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC trans rs6076960 0.652 rs6085467 chr20:6259004 T/C cg17788362 chr6:86352627 SYNCRIP 0.46 6.93 0.35 2.12e-11 Smooth-surface caries; LUSC cis rs870825 0.616 rs7660939 chr4:185640792 T/C cg04058563 chr4:185651563 MLF1IP 0.86 13.38 0.59 5.34e-33 Blood protein levels; LUSC cis rs28374715 0.662 rs522063 chr15:41476209 A/G cg18705301 chr15:41695430 NDUFAF1 0.81 15.24 0.64 3.52e-40 Ulcerative colitis; LUSC cis rs7659604 0.540 rs11724322 chr4:122697850 A/T cg20573242 chr4:122745356 CCNA2 -0.45 -6.76 -0.35 6.17e-11 Type 2 diabetes; LUSC cis rs57920188 0.640 rs4311852 chr1:4085353 C/A cg20703997 chr1:4087676 NA 0.59 8.52 0.42 5.66e-16 Interleukin-17 levels; LUSC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg02931644 chr1:25747376 RHCE 0.33 5.95 0.31 6.84e-9 Erythrocyte sedimentation rate; LUSC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.84 0.35 3.83e-11 Intelligence (multi-trait analysis); LUSC cis rs9929218 0.529 rs11075694 chr16:68730366 C/T cg01251360 chr16:68772225 CDH1 -0.26 -6.09 -0.32 3.15e-9 Colorectal cancer; LUSC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg05425664 chr17:57184151 TRIM37 0.54 8.04 0.4 1.53e-14 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg18827107 chr12:86230957 RASSF9 0.45 6.87 0.35 3.17e-11 Major depressive disorder; LUSC trans rs7395662 0.591 rs11039858 chr11:48611651 C/T cg15704280 chr7:45808275 SEPT13 -0.45 -5.98 -0.31 5.77e-9 HDL cholesterol; LUSC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg05425664 chr17:57184151 TRIM37 -0.55 -8.2 -0.41 5.31e-15 Intelligence (multi-trait analysis); LUSC cis rs1080500 1.000 rs1080500 chr3:53175017 C/T cg18099408 chr3:52552593 STAB1 -0.4 -6.42 -0.33 4.62e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs2204008 0.614 rs4578492 chr12:38036350 T/C cg06521331 chr12:34319734 NA -0.39 -5.95 -0.31 6.77e-9 Bladder cancer; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.73 -0.39 1.31e-13 Lymphocyte counts; LUSC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs7666738 0.606 rs4699611 chr4:99097492 T/G cg05340658 chr4:99064831 C4orf37 0.58 9.37 0.46 1.14e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs6912958 0.781 rs2207146 chr6:88180641 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -8.99 -0.44 1.83e-17 Monocyte percentage of white cells; LUSC cis rs17125944 0.542 rs75723366 chr14:53256882 T/C cg00686598 chr14:53173677 PSMC6 1.16 10.58 0.5 9.4e-23 Alzheimer's disease (late onset); LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.05 0.4 1.43e-14 Bipolar disorder; LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg21782813 chr7:2030301 MAD1L1 0.41 6.82 0.35 4.29e-11 Bipolar disorder and schizophrenia; LUSC cis rs55665837 1.000 rs11023215 chr11:14436970 C/T cg05501817 chr11:14380813 RRAS2 -0.39 -6.28 -0.33 1.03e-9 Vitamin D levels; LUSC cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.78 0.39 9.05e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg12311346 chr5:56204834 C5orf35 -0.94 -13.05 -0.58 9.74e-32 Type 2 diabetes; LUSC cis rs2288073 0.965 rs10469924 chr2:24416230 G/A cg06627628 chr2:24431161 ITSN2 -0.78 -11.39 -0.53 1.28e-25 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs6840360 0.593 rs1366907 chr4:152682749 T/C cg22705602 chr4:152727874 NA -0.34 -7.58 -0.38 3.36e-13 Intelligence (multi-trait analysis); LUSC cis rs1624802 0.638 rs1696431 chr12:130498408 C/T cg15444478 chr12:130494697 NA 0.25 5.75 0.3 1.97e-8 Obesity-related traits; LUSC cis rs3761218 0.714 rs1968648 chr20:3763349 C/T cg02737268 chr20:3780182 CDC25B -0.33 -6.69 -0.34 9.25e-11 Bipolar disorder; LUSC cis rs6121246 0.821 rs6121209 chr20:30311258 G/C cg13852791 chr20:30311386 BCL2L1 0.89 12.16 0.55 2.05e-28 Mean corpuscular hemoglobin; LUSC cis rs11039100 0.765 rs1032648 chr11:5782756 A/G cg13902645 chr11:5959945 NA -0.55 -6.05 -0.31 3.83e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg06550200 chr5:1325588 CLPTM1L -0.68 -11.7 -0.54 9.55e-27 Lung cancer; LUSC cis rs8179 1.000 rs42031 chr7:92237396 A/T cg15732164 chr7:92237376 CDK6 -0.55 -7.41 -0.38 1.01e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs970548 0.730 rs61854093 chr10:45934881 C/A cg15590007 chr10:45870220 ALOX5 0.5 5.7 0.3 2.62e-8 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs7180079 0.620 rs686634 chr15:64854511 A/G cg08069370 chr15:64387884 SNX1 0.51 5.74 0.3 2.13e-8 Monocyte count; LUSC cis rs41271473 0.526 rs1925720 chr1:228728377 G/C cg16512390 chr1:228756714 NA 0.7 8.89 0.44 4.03e-17 Chronic lymphocytic leukemia; LUSC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg02034447 chr16:89574710 SPG7 0.42 6.14 0.32 2.34e-9 Multiple myeloma (IgH translocation); LUSC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg04352962 chr1:209979756 IRF6 0.53 6.32 0.33 8.42e-10 Cleft lip with or without cleft palate; LUSC cis rs80130819 0.515 rs1793912 chr12:48387052 A/C cg24011408 chr12:48396354 COL2A1 0.5 6.36 0.33 6.75e-10 Prostate cancer; LUSC cis rs71403859 0.502 rs12708914 chr16:71470636 G/A cg08717414 chr16:71523259 ZNF19 -0.65 -7.91 -0.4 3.69e-14 Post bronchodilator FEV1; LUSC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg23093090 chr10:104574429 C10orf26 -0.45 -8.43 -0.42 1.02e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg09491104 chr22:46646882 C22orf40 -0.67 -7.0 -0.36 1.42e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg07507251 chr3:52567010 NT5DC2 -0.3 -5.95 -0.31 6.77e-9 Bipolar disorder; LUSC cis rs3740540 0.530 rs4297414 chr10:126292116 T/G cg04949429 chr10:126290192 LHPP 0.36 7.7 0.39 1.58e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC trans rs12579753 1.000 rs12827923 chr12:82242067 G/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs11112613 0.609 rs7350593 chr12:106038119 C/T cg03607813 chr12:105948248 NA 0.63 8.01 0.4 1.95e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs11018904 0.817 rs11601793 chr11:89946354 T/G cg26138821 chr11:89956704 CHORDC1 -0.58 -6.66 -0.34 1.1e-10 Intelligence (multi-trait analysis); LUSC cis rs2067615 0.524 rs7309351 chr12:107077432 C/T cg15890332 chr12:107067104 RFX4 -0.35 -6.15 -0.32 2.22e-9 Heart rate; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg13395646 chr4:1353034 KIAA1530 0.49 6.93 0.35 2.19e-11 Obesity-related traits; LUSC cis rs600626 0.636 rs10899110 chr11:75452342 C/G cg24262691 chr11:75473276 NA 0.5 6.77 0.35 5.8200000000000003e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg06092702 chr1:163392909 NA -0.44 -7.33 -0.37 1.75e-12 Motion sickness; LUSC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg22532475 chr10:104410764 TRIM8 -0.31 -6.96 -0.36 1.81e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg03146154 chr1:46216737 IPP -0.58 -8.36 -0.42 1.7e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9399135 0.967 rs45544135 chr6:135324051 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.22 0.45 3.55e-18 Red blood cell count; LUSC cis rs2857891 0.817 rs2239733 chr11:6976666 T/C cg14883916 chr11:6947541 ZNF215 0.45 5.87 0.31 1.06e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs262150 0.659 rs73167293 chr7:158772638 C/T cg19418458 chr7:158789849 NA 0.47 5.94 0.31 7.3e-9 Facial morphology (factor 20); LUSC cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg13010199 chr12:38710504 ALG10B 0.67 10.38 0.49 4.53e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg06092702 chr1:163392909 NA -0.47 -7.84 -0.39 6.13e-14 Motion sickness; LUSC cis rs10887741 0.966 rs7085195 chr10:89429897 T/C cg24243914 chr10:89418206 PAPSS2 0.32 5.98 0.31 5.79e-9 Exercise (leisure time); LUSC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg22963979 chr7:1858916 MAD1L1 -0.52 -7.67 -0.39 1.84e-13 Schizophrenia; LUSC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg08499158 chr17:42289980 UBTF 0.42 6.38 0.33 5.78e-10 Total body bone mineral density; LUSC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg07701084 chr6:150067640 NUP43 0.58 9.03 0.44 1.36e-17 Lung cancer; LUSC cis rs10779751 1.000 rs10779751 chr1:11284336 A/G cg08854313 chr1:11322531 MTOR 0.87 14.45 0.62 4.15e-37 Body mass index; LUSC cis rs709400 0.628 rs3783394 chr14:103858673 G/A cg10523860 chr14:103875565 MARK3 -0.4 -6.44 -0.33 4.18e-10 Body mass index; LUSC cis rs7647973 0.626 rs9870858 chr3:49769071 C/T cg13072238 chr3:49761600 GMPPB -0.63 -8.19 -0.41 5.63e-15 Menarche (age at onset); LUSC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg06636001 chr8:8085503 FLJ10661 0.71 11.66 0.54 1.43e-26 Mood instability; LUSC cis rs9527 0.641 rs34130454 chr10:104903638 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07226813 chr3:49044374 P4HTM;WDR6 0.46 6.72 0.35 7.75e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg08088566 chr11:430123 ANO9 0.65 7.24 0.37 3.08e-12 Body mass index; LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg07404485 chr7:94953653 PON1 -0.31 -5.98 -0.31 5.78e-9 Paraoxonase activity; LUSC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.41 6.57 0.34 1.97e-10 Personality dimensions; LUSC cis rs60733400 0.818 rs10909839 chr1:2708430 G/A cg18854424 chr1:2615690 NA 0.48 9.3 0.45 1.85e-18 Multiple sclerosis; LUSC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg15790184 chr11:494944 RNH1 0.42 6.21 0.32 1.61e-9 Systemic lupus erythematosus; LUSC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg00339695 chr16:24857497 SLC5A11 -0.61 -9.23 -0.45 3.25e-18 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs6115159 chr20:25350944 T/C cg08601574 chr20:25228251 PYGB -0.42 -6.43 -0.33 4.39e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg25427524 chr10:38739819 LOC399744 -0.74 -14.08 -0.61 1.14e-35 Extrinsic epigenetic age acceleration; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg00431813 chr7:1051703 C7orf50 -0.4 -6.24 -0.32 1.31e-9 Longevity;Endometriosis; LUSC cis rs8114671 0.562 rs2424999 chr20:33386430 G/A cg08999081 chr20:33150536 PIGU 0.38 6.82 0.35 4.36e-11 Height; LUSC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg26314531 chr2:26401878 FAM59B 0.73 9.71 0.47 8.38e-20 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg13114125 chr14:105738426 BRF1 -0.92 -15.77 -0.65 2.85e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg20503657 chr10:835505 NA 0.77 8.96 0.44 2.39e-17 Eosinophil percentage of granulocytes; LUSC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg08213375 chr14:104286397 PPP1R13B 0.44 7.61 0.38 2.78e-13 Reticulocyte count; LUSC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.93 0.35 2.16e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs708547 0.647 rs1277308 chr4:57897864 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.5 7.45 0.38 7.8e-13 Response to bleomycin (chromatid breaks); LUSC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg02221750 chr19:17393354 ANKLE1 -0.92 -14.22 -0.61 3.42e-36 Systemic lupus erythematosus; LUSC cis rs950027 0.620 rs1145080 chr15:45681338 C/T cg21132104 chr15:45694354 SPATA5L1 0.4 5.94 0.31 7.32e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg25767906 chr1:53392781 SCP2 -0.48 -8.62 -0.43 2.76e-16 Monocyte count; LUSC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg12667521 chr19:29218732 NA 0.57 6.96 0.36 1.77e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg23630131 chr7:65973040 NA 0.2 5.73 0.3 2.29e-8 Aortic root size; LUSC cis rs3820928 0.874 rs2229812 chr2:227896886 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.4e-13 Pulmonary function; LUSC cis rs9393777 0.623 rs3757150 chr6:26476782 T/A cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16587794 chr15:69706675 KIF23 0.78 6.28 0.32 1.07e-9 Cognitive performance; LUSC cis rs10186029 0.676 rs1025820 chr2:213933778 T/G cg08319019 chr2:214017104 IKZF2 0.61 8.99 0.44 1.9e-17 Systemic sclerosis; LUSC cis rs3008870 0.755 rs4655661 chr1:67408828 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.3 0.56 6.01e-29 Lymphocyte percentage of white cells; LUSC cis rs12618769 0.597 rs2278214 chr2:99135738 A/G cg10123293 chr2:99228465 UNC50 -0.45 -7.42 -0.38 9.52e-13 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22924838 chr2:200715629 NA 0.42 6.33 0.33 7.77e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7633770 0.841 rs11709020 chr3:46680063 A/G cg11219411 chr3:46661640 NA -0.37 -7.02 -0.36 1.22e-11 Coronary artery disease; LUSC cis rs9463078 0.605 rs3799981 chr6:44882380 T/A cg25276700 chr6:44698697 NA 0.29 5.95 0.31 6.88e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg21573476 chr21:45109991 RRP1B -0.36 -5.93 -0.31 7.63e-9 Mean corpuscular volume; LUSC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg14004847 chr7:1930337 MAD1L1 -0.52 -7.99 -0.4 2.27e-14 Bipolar disorder and schizophrenia; LUSC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg01017244 chr2:74357527 NA 0.69 13.32 0.59 9.32e-33 Gestational age at birth (maternal effect); LUSC cis rs881375 0.702 rs3761847 chr9:123690239 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 5.97 0.31 5.93e-9 Rheumatoid arthritis; LUSC cis rs2274273 0.624 rs3783651 chr14:55850973 G/C cg04306507 chr14:55594613 LGALS3 0.48 9.52 0.46 3.69e-19 Protein biomarker; LUSC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg05861140 chr6:150128134 PCMT1 0.4 6.37 0.33 6.22e-10 Lung cancer; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg24846343 chr22:24311635 DDTL 0.66 14.14 0.61 6.41e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1577917 0.917 rs4098044 chr6:86462066 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.77 -0.35 5.87e-11 Response to antipsychotic treatment; LUSC cis rs13315871 0.929 rs7628038 chr3:58313813 T/C cg20936604 chr3:58311152 NA -0.72 -6.95 -0.36 1.94e-11 Cholesterol, total; LUSC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg06505273 chr16:24850292 NA -0.4 -5.75 -0.3 1.98e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs10896135 0.526 rs624561 chr11:66414915 C/T cg24851651 chr11:66362959 CCS -0.52 -8.35 -0.42 1.87e-15 Bipolar disorder; LUSC cis rs870825 0.616 rs6419939 chr4:185642869 C/T cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg27286337 chr10:134555280 INPP5A 0.92 11.6 0.54 2.24e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2731664 0.792 rs179809 chr5:176865329 T/G cg23176889 chr5:176863531 GRK6 -0.68 -13.83 -0.6 1.02e-34 Intelligence (multi-trait analysis); LUSC cis rs28785552 0.796 rs8112908 chr19:53248041 C/T cg10871876 chr19:53194124 ZNF83 0.57 8.76 0.43 9.76e-17 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.566 rs72796106 chr2:23901362 A/C cg20701182 chr2:24300061 SF3B14 0.72 7.88 0.4 4.55e-14 Lymphocyte counts; LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7917772 0.582 rs729024 chr10:104341975 T/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg13683864 chr3:40499215 RPL14 -0.94 -15.93 -0.66 6.81e-43 Renal cell carcinoma; LUSC cis rs3784262 1.000 rs7170896 chr15:58252393 T/A cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.83 -0.3 1.3e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg00579200 chr11:133705235 NA -0.41 -5.82 -0.3 1.38e-8 Childhood ear infection; LUSC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg11752832 chr7:134001865 SLC35B4 0.61 9.65 0.47 1.35e-19 Mean platelet volume; LUSC trans rs10802346 0.545 rs2362252 chr1:246371574 A/C cg22732515 chr19:44031385 ETHE1 0.63 10.27 0.49 1.1e-21 Fractional exhaled nitric oxide (childhood); LUSC cis rs4631830 0.812 rs11593361 chr10:51539156 A/G cg10326726 chr10:51549505 MSMB -0.36 -6.07 -0.32 3.55e-9 Prostate-specific antigen levels; LUSC cis rs354225 0.584 rs7586311 chr2:54810762 A/G cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC trans rs11700980 0.551 rs2832040 chr21:30115840 C/T cg14791747 chr16:20752902 THUMPD1 0.55 6.01 0.31 4.94e-9 QRS complex (12-leadsum); LUSC cis rs9395066 0.527 rs55893720 chr6:44955716 G/T cg25276700 chr6:44698697 NA 0.29 5.8 0.3 1.53e-8 Height; LUSC cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 9.28e-24 Bladder cancer; LUSC cis rs34779708 0.868 rs2384352 chr10:35492832 A/G cg03585969 chr10:35415529 CREM 0.63 9.19 0.45 4.4e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17401966 0.522 rs2027330 chr1:10275592 C/T cg19773385 chr1:10388646 KIF1B -0.37 -6.46 -0.33 3.61e-10 Hepatocellular carcinoma; LUSC cis rs1712517 0.771 rs11191672 chr10:105138961 C/T cg05636881 chr10:105038444 INA 0.4 6.59 0.34 1.67e-10 Migraine; LUSC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg03690763 chr11:133734501 NA -0.32 -5.68 -0.3 2.98e-8 Childhood ear infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22308382 chr13:28194838 POLR1D;LNX2 -0.42 -6.17 -0.32 1.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10189230 0.967 rs1367241 chr2:222353413 G/A cg14652038 chr2:222343519 EPHA4 0.32 5.73 0.3 2.29e-8 Urate levels in lean individuals; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14783646 chr7:4800873 FOXK1 0.47 6.33 0.33 7.95e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg02269571 chr22:50332266 NA 0.56 8.27 0.41 3.33e-15 Schizophrenia; LUSC trans rs61931739 0.500 rs7298322 chr12:34445489 A/T cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.51e-34 Morning vs. evening chronotype; LUSC cis rs11155671 0.530 rs4869764 chr6:150211828 T/C cg09699651 chr6:150184138 LRP11 0.45 7.17 0.37 4.98e-12 Testicular germ cell tumor; LUSC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg26818010 chr10:134567672 INPP5A -0.84 -10.95 -0.51 4.73e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg18252515 chr7:66147081 NA 1.25 14.23 0.61 3.05e-36 Diabetic kidney disease; LUSC cis rs4820539 1.000 rs13054985 chr22:23458577 G/A cg21100191 chr22:23484243 RTDR1 0.91 15.35 0.64 1.27e-40 Bone mineral density; LUSC cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg21535247 chr6:8435926 SLC35B3 0.58 8.97 0.44 2.22e-17 Motion sickness; LUSC trans rs34421088 0.586 rs2272594 chr8:11142625 T/C cg06636001 chr8:8085503 FLJ10661 0.51 7.4 0.38 1.15e-12 Neuroticism; LUSC cis rs2656056 1 rs2656056 chr15:78722519 T/C cg06917634 chr15:78832804 PSMA4 0.47 5.95 0.31 6.95e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg06138931 chr13:21896616 NA 0.4 6.74 0.35 6.78e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs1395 0.744 rs11126935 chr2:27476740 G/T cg23587288 chr2:27483067 SLC30A3 -0.29 -5.7 -0.3 2.61e-8 Blood metabolite levels; LUSC cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.56 0.46 2.61e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg06877462 chr1:205807181 PM20D1 0.5 9.03 0.44 1.43e-17 Menarche (age at onset); LUSC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg25554036 chr4:6271136 WFS1 0.61 12.6 0.57 4.91e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.93 0.48 1.55e-20 Bipolar disorder; LUSC cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.54 0.42 4.66e-16 Menopause (age at onset); LUSC cis rs7927592 0.913 rs10896347 chr11:68353127 G/A cg01657329 chr11:68192670 LRP5 -0.4 -5.77 -0.3 1.85e-8 Total body bone mineral density; LUSC trans rs7939886 0.841 rs1905053 chr11:56011848 C/T cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs243505 0.762 rs10225300 chr7:148502007 G/C cg09806900 chr7:148480153 CUL1 0.58 8.53 0.42 5.2e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg26924012 chr15:45694286 SPATA5L1 1.13 20.71 0.75 7.34e-62 Homoarginine levels; LUSC cis rs8077889 1.000 rs17674998 chr17:41879544 A/G cg26893861 chr17:41843967 DUSP3 0.9 13.19 0.59 2.88e-32 Triglycerides; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05061393 chr2:220043337 FAM134A -0.39 -6.84 -0.35 3.8e-11 Electrocardiographic conduction measures; LUSC cis rs701145 0.556 rs355787 chr3:153994502 T/C cg10247383 chr3:153839028 SGEF -0.48 -5.85 -0.3 1.18e-8 Coronary artery disease; LUSC cis rs2742417 0.603 rs2742372 chr3:45783472 T/C cg10512202 chr3:45649293 LIMD1 0.36 6.09 0.32 3.17e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg15997130 chr1:24165203 NA -0.49 -7.33 -0.37 1.8e-12 Immature fraction of reticulocytes; LUSC cis rs7215564 0.730 rs76584516 chr17:78549237 A/G cg23238734 chr17:78661607 RPTOR 0.53 6.24 0.32 1.35e-9 Myopia (pathological); LUSC cis rs1577917 0.958 rs1414199 chr6:86522370 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.63 -0.34 1.37e-10 Response to antipsychotic treatment; LUSC cis rs5758511 0.573 rs139558 chr22:42189551 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.39 -7.41 -0.38 1.03e-12 Birth weight; LUSC cis rs4595586 0.545 rs12816776 chr12:39375817 A/G cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.45 0.42 8.88e-16 Motion sickness; LUSC trans rs1864729 1.000 rs1864729 chr8:98282189 G/A cg08679828 chr8:102218111 ZNF706 -0.87 -7.9 -0.4 3.95e-14 Estradiol plasma levels (breast cancer); LUSC cis rs10905065 0.759 rs1533215 chr10:5869767 T/C cg25171089 chr10:5708825 ASB13 0.4 5.7 0.3 2.7e-8 Menopause (age at onset); LUSC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg24879335 chr3:133465180 TF 0.44 7.53 0.38 4.8e-13 Iron status biomarkers (transferrin levels); LUSC trans rs1908814 0.516 rs4367597 chr8:11793529 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.2e-15 Neuroticism; LUSC cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg02527881 chr3:46936655 PTH1R -0.38 -6.7 -0.34 8.97e-11 Colorectal cancer; LUSC cis rs2880765 0.835 rs11633604 chr15:86031579 T/G cg13263323 chr15:86062960 AKAP13 -0.35 -5.72 -0.3 2.38e-8 Coronary artery disease; LUSC cis rs6840360 0.967 rs10049728 chr4:152672121 C/G cg22705602 chr4:152727874 NA -0.26 -5.7 -0.3 2.62e-8 Intelligence (multi-trait analysis); LUSC cis rs977987 0.806 rs35937717 chr16:75331567 C/A cg03315344 chr16:75512273 CHST6 0.5 9.61 0.47 1.77e-19 Dupuytren's disease; LUSC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs427941 0.632 rs201497 chr7:101755928 A/C cg06246474 chr7:101738831 CUX1 0.39 6.32 0.33 8.14e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7215564 0.908 rs34135683 chr17:78652903 G/T cg23238734 chr17:78661607 RPTOR 0.48 6.13 0.32 2.5e-9 Myopia (pathological); LUSC cis rs1150668 0.764 rs9368565 chr6:28345210 C/T cg21251018 chr6:28226885 NKAPL -0.31 -5.77 -0.3 1.82e-8 Pubertal anthropometrics; LUSC cis rs9660992 0.512 rs12123773 chr1:205122420 C/G cg00857998 chr1:205179979 DSTYK 0.67 10.68 0.5 4.31e-23 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1534166 0.602 rs3817524 chr3:133526403 C/T cg01448562 chr3:133502909 NA 0.49 7.61 0.38 2.75e-13 Alcohol consumption (transferrin glycosylation); LUSC trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg03929089 chr4:120376271 NA -0.84 -11.51 -0.53 4.83e-26 Coronary artery disease; LUSC cis rs7590368 0.715 rs72779453 chr2:10959475 G/C cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs17030434 1.000 rs12651051 chr4:154722114 A/G cg14289246 chr4:154710475 SFRP2 -0.51 -6.54 -0.34 2.35e-10 Electrocardiographic conduction measures; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04141459 chr3:183852329 EIF2B5 0.44 6.0 0.31 5e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.16 -0.41 6.92e-15 Lung cancer; LUSC cis rs1775715 0.737 rs1419171 chr10:32214831 C/A cg26784012 chr10:32216390 ARHGAP12 0.44 7.32 0.37 1.9e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9902453 0.612 rs2617868 chr17:28073247 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.17 -0.52 7.69e-25 Coffee consumption (cups per day); LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg22963979 chr7:1858916 MAD1L1 -0.5 -7.65 -0.39 2.19e-13 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg13010199 chr12:38710504 ALG10B 0.7 10.93 0.51 5.81e-24 Bladder cancer; LUSC trans rs7819412 0.715 rs2409727 chr8:11043236 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -6.5 -0.34 2.85e-10 Triglycerides; LUSC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg06221963 chr1:154839813 KCNN3 -0.6 -13.38 -0.59 5.65e-33 Prostate cancer; LUSC cis rs3857536 0.813 rs7771569 chr6:66946717 C/T cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs8014204 0.836 rs12588415 chr14:75278211 G/A cg06637938 chr14:75390232 RPS6KL1 0.65 10.87 0.51 9.27e-24 Caffeine consumption; LUSC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg10169327 chr19:45448959 APOC2 0.31 6.66 0.34 1.15e-10 Blood protein levels; LUSC cis rs11098499 0.535 rs10005542 chr4:120268302 T/C cg09307838 chr4:120376055 NA 0.64 9.62 0.47 1.69e-19 Corneal astigmatism; LUSC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg23711669 chr6:146136114 FBXO30 0.76 12.23 0.56 1.09e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs9902453 0.780 rs7210991 chr17:28190961 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.67 0.47 1.16e-19 Coffee consumption (cups per day); LUSC cis rs713477 0.967 rs6573032 chr14:55913776 A/G cg13175173 chr14:55914753 NA -0.31 -6.49 -0.33 3.05e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg12463550 chr7:65579703 CRCP -0.52 -7.63 -0.39 2.48e-13 Aortic root size; LUSC cis rs2180341 0.594 rs7738385 chr6:127777516 T/C cg27446573 chr6:127587934 RNF146 0.57 8.48 0.42 7.37e-16 Breast cancer; LUSC cis rs2073300 0.609 rs6137938 chr20:23389127 C/G cg12062639 chr20:23401060 NAPB 0.96 8.09 0.4 1.12e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg04733989 chr22:42467013 NAGA 0.4 6.46 0.33 3.69e-10 Cognitive function; LUSC cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.81e-30 Motion sickness; LUSC cis rs1670533 1.000 rs10084849 chr4:1053586 T/C cg02018176 chr4:1364513 KIAA1530 0.43 6.15 0.32 2.24e-9 Recombination rate (females); LUSC cis rs9837602 1.000 rs793496 chr3:99507254 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -5.73 -0.3 2.26e-8 Breast cancer; LUSC cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg24375607 chr4:120327624 NA 0.77 11.22 0.52 5.19e-25 Corneal astigmatism; LUSC cis rs1113500 1.000 rs1113500 chr1:108595442 G/T cg06207961 chr1:108661230 NA -0.41 -7.55 -0.38 4.06e-13 Growth-regulated protein alpha levels; LUSC cis rs6484504 0.625 rs672396 chr11:31386165 A/G cg06552810 chr11:31128660 NA 0.39 6.77 0.35 5.87e-11 Red blood cell count; LUSC cis rs782590 0.774 rs2627773 chr2:55900459 A/G cg03859395 chr2:55845619 SMEK2 0.86 15.55 0.65 2.13e-41 Metabolic syndrome; LUSC cis rs17001868 0.568 rs9611311 chr22:40733951 T/C cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg08917208 chr2:24149416 ATAD2B 0.54 6.01 0.31 4.87e-9 Lymphocyte counts; LUSC cis rs874628 0.686 rs11666906 chr19:18241898 A/G cg00493341 chr19:18228948 MAST3 0.45 6.28 0.32 1.06e-9 Multiple sclerosis; LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg01802117 chr1:53393560 SCP2 -0.39 -6.38 -0.33 5.85e-10 Monocyte count; LUSC trans rs2727020 0.553 rs3862350 chr11:49595912 A/C cg03929089 chr4:120376271 NA -0.95 -16.2 -0.66 5.7e-44 Coronary artery disease; LUSC trans rs6951245 1.000 rs74785791 chr7:1088494 T/C cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg13047869 chr3:10149882 C3orf24 0.63 9.07 0.44 1.02e-17 Alzheimer's disease; LUSC cis rs12541635 0.966 rs62527363 chr8:107024258 A/G cg10147462 chr8:107024639 NA 0.56 10.1 0.48 4.08e-21 Age of smoking initiation; LUSC cis rs17826219 0.561 rs11655876 chr17:29017150 G/A cg13385521 chr17:29058706 SUZ12P 0.58 5.97 0.31 6.22e-9 Body mass index; LUSC cis rs7804356 0.954 rs6948584 chr7:26855732 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.2 -0.32 1.66e-9 Type 1 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg19670317 chr17:8093380 C17orf59 -0.46 -6.32 -0.33 8.13e-10 Hepatitis; LUSC cis rs12824058 0.737 rs2398510 chr12:130816637 G/A cg24838063 chr12:130822603 PIWIL1 0.69 10.6 0.5 7.8e-23 Menopause (age at onset); LUSC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -10.21 -0.49 1.75e-21 Developmental language disorder (linguistic errors); LUSC cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.71e-9 Body mass index; LUSC cis rs2742417 0.603 rs2742395 chr3:45758595 A/G cg04837898 chr3:45731254 SACM1L -0.46 -7.36 -0.37 1.42e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC cis rs136211 0.662 rs9607338 chr22:36759026 C/T cg10790723 chr22:36903033 FOXRED2 0.4 5.83 0.3 1.29e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg24733560 chr20:60626293 TAF4 0.45 8.15 0.41 7.2e-15 Body mass index; LUSC cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg24112000 chr20:60950667 NA -0.45 -8.0 -0.4 2.01e-14 Colorectal cancer; LUSC cis rs7615316 0.902 rs9825207 chr3:142304543 T/C cg16271453 chr3:142027066 XRN1 -0.35 -5.9 -0.31 8.83e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs478304 0.651 rs12225620 chr11:65505448 T/C cg05805236 chr11:65401703 PCNXL3 -0.57 -9.34 -0.46 1.38e-18 Acne (severe); LUSC cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -7.46 -0.38 7.48e-13 Menarche (age at onset); LUSC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg13047869 chr3:10149882 C3orf24 -0.56 -8.03 -0.4 1.73e-14 Alzheimer's disease; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg24739457 chr1:205821442 NA 0.36 6.2 0.32 1.63e-9 Menarche (age at onset); LUSC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs6009527 0.963 rs6009532 chr22:49572757 C/G cg12746016 chr22:49560550 NA 0.37 6.22 0.32 1.51e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs8113142 0.651 rs10500236 chr19:29091594 C/T cg04546413 chr19:29218101 NA 0.44 6.05 0.31 3.89e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.0 -0.36 1.43e-11 Blood metabolite levels; LUSC trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg12463550 chr7:65579703 CRCP 0.45 6.18 0.32 1.84e-9 Aortic root size; LUSC cis rs9303401 0.659 rs7223708 chr17:56896398 A/G cg25039879 chr17:56429692 SUPT4H1 0.67 9.01 0.44 1.65e-17 Cognitive test performance; LUSC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs1949733 0.701 rs1880024 chr4:8454639 A/G cg11789530 chr4:8429930 ACOX3 0.59 9.02 0.44 1.53e-17 Response to antineoplastic agents; LUSC cis rs4295623 0.789 rs12541318 chr8:11594970 G/T cg21775007 chr8:11205619 TDH -0.47 -6.63 -0.34 1.34e-10 Morning vs. evening chronotype; LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC cis rs4903214 0.895 rs7157482 chr14:74712696 C/T cg08255017 chr14:74727001 VSX2 -0.52 -7.1 -0.36 7.44e-12 Inflammatory bowel disease; LUSC cis rs7568458 0.870 rs6719046 chr2:85757371 G/A cg17127132 chr2:85788382 GGCX 0.47 7.66 0.39 1.99e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg12016809 chr21:47604291 C21orf56 0.46 7.07 0.36 8.84e-12 Testicular germ cell tumor; LUSC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg01475377 chr6:109611718 NA -0.37 -6.46 -0.33 3.61e-10 Reticulocyte fraction of red cells; LUSC cis rs10416265 0.528 rs3826906 chr19:33620897 C/T cg17764715 chr19:33622953 WDR88 0.56 6.33 0.33 7.93e-10 Bone properties (heel); LUSC cis rs1728785 1.000 rs1728781 chr16:68567794 A/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg06305312 chr1:19638330 AKR7A2;PQLC2 0.41 6.2 0.32 1.69e-9 Schizophrenia; LUSC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg10018233 chr7:150070692 REPIN1 0.39 6.43 0.33 4.37e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs61931739 0.534 rs2220547 chr12:34106255 G/A cg06521331 chr12:34319734 NA -0.5 -8.16 -0.41 7.12e-15 Morning vs. evening chronotype; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg06877462 chr1:205807181 PM20D1 -0.5 -9.07 -0.44 1.07e-17 Menarche (age at onset); LUSC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg02564969 chr6:151773285 C6orf211;RMND1 -0.49 -7.44 -0.38 8.34e-13 Menarche (age at onset); LUSC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg12560992 chr17:57184187 TRIM37 0.82 14.75 0.63 2.92e-38 Intelligence (multi-trait analysis); LUSC cis rs950776 0.518 rs12906846 chr15:78825295 G/A cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs7568458 0.837 rs3770098 chr2:85805367 C/A cg02493740 chr2:85810744 VAMP5 -0.32 -5.78 -0.3 1.72e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg17830980 chr10:43048298 ZNF37B -0.39 -6.09 -0.32 3.12e-9 Extrinsic epigenetic age acceleration; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg22907277 chr7:1156413 C7orf50 0.45 6.8 0.35 4.95e-11 Longevity;Endometriosis; LUSC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11644478 chr21:40555479 PSMG1 0.85 14.75 0.63 2.79e-38 Cognitive function; LUSC cis rs877282 0.945 rs17293517 chr10:778770 C/T cg17470449 chr10:769945 NA 0.51 7.02 0.36 1.24e-11 Uric acid levels; LUSC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg22800045 chr5:56110881 MAP3K1 0.44 6.07 0.31 3.57e-9 Coronary artery disease; LUSC cis rs1728785 1.000 rs1728781 chr16:68567794 A/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs1371867 0.555 rs2861348 chr8:101285074 A/G cg06636551 chr8:101224915 SPAG1 -0.39 -7.37 -0.37 1.38e-12 Atrioventricular conduction; LUSC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg08949735 chr16:89699720 DPEP1 -0.24 -5.76 -0.3 1.96e-8 Vitiligo; LUSC cis rs6831352 0.879 rs1984362 chr4:100070973 G/A cg13256891 chr4:100009986 ADH5 -0.49 -6.43 -0.33 4.41e-10 Alcohol dependence; LUSC cis rs877282 0.853 rs11593836 chr10:756715 G/A cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs7605827 0.930 rs2052439 chr2:15702029 C/G cg19274914 chr2:15703543 NA 0.48 9.24 0.45 2.91e-18 Educational attainment (years of education); LUSC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.91 -14.3 -0.62 1.59e-36 Multiple sclerosis; LUSC cis rs1395 0.710 rs11674947 chr2:27471996 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 7.06 0.36 9.64e-12 Blood metabolite levels; LUSC cis rs2806561 0.780 rs12135629 chr1:23338899 A/G cg19743168 chr1:23544995 NA -0.37 -7.74 -0.39 1.16e-13 Height; LUSC cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg19875535 chr5:140030758 IK 0.47 7.57 0.38 3.58e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs7927592 0.871 rs11228284 chr11:68322767 A/T cg01657329 chr11:68192670 LRP5 -0.39 -5.67 -0.3 3.17e-8 Total body bone mineral density; LUSC cis rs76878669 0.561 rs4630308 chr11:66162587 G/A cg24851651 chr11:66362959 CCS -0.38 -6.06 -0.31 3.72e-9 Educational attainment (years of education); LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg11905131 chr22:24372483 LOC391322 -0.5 -7.71 -0.39 1.47e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs601339 1.000 rs509548 chr12:123181855 T/A cg11919336 chr12:123188078 GPR109A 0.44 6.58 0.34 1.87e-10 Adiponectin levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15441230 chr15:44069583 ELL3 -0.49 -6.01 -0.31 4.81e-9 Bipolar disorder and schizophrenia; LUSC cis rs877282 0.898 rs11253344 chr10:765162 C/T cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC cis rs1023500 0.573 rs8135801 chr22:42475568 A/G cg04733989 chr22:42467013 NAGA -0.61 -9.49 -0.46 4.48e-19 Schizophrenia; LUSC cis rs6503525 0.628 rs62068171 chr17:38103242 G/A cg26162295 chr17:38119207 GSDMA -0.29 -6.96 -0.36 1.85e-11 Asthma; LUSC cis rs9733 0.650 rs9803935 chr1:150552622 T/G cg09365446 chr1:150670422 GOLPH3L -0.41 -5.94 -0.31 7.12e-9 Tonsillectomy; LUSC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg08677398 chr8:58056175 NA 0.47 5.94 0.31 7.29e-9 Developmental language disorder (linguistic errors); LUSC trans rs877282 0.838 rs11253373 chr10:774857 A/G cg22713356 chr15:30763199 NA 1.09 15.3 0.64 2.06e-40 Uric acid levels; LUSC cis rs950776 0.593 rs6495306 chr15:78865893 C/T cg06917634 chr15:78832804 PSMA4 -0.74 -12.67 -0.57 2.64e-30 Sudden cardiac arrest; LUSC cis rs7598759 0.548 rs11686485 chr2:232360697 C/T cg19187155 chr2:232395269 NMUR1 0.92 15.91 0.66 7.75e-43 Noise-induced hearing loss; LUSC trans rs60843830 1.000 rs60843830 chr2:286756 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 10.15 0.49 2.74e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg07507251 chr3:52567010 NT5DC2 0.33 6.61 0.34 1.49e-10 Bipolar disorder; LUSC cis rs4948275 0.550 rs7082786 chr10:63176990 C/A cg03237606 chr10:63212265 TMEM26 -0.39 -5.99 -0.31 5.3e-9 Night sleep phenotypes; LUSC cis rs514406 0.536 rs878957 chr1:53197559 C/T cg24675658 chr1:53192096 ZYG11B 0.79 14.06 0.61 1.4e-35 Monocyte count; LUSC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg18230493 chr5:56204884 C5orf35 -0.61 -9.5 -0.46 4.27e-19 Coronary artery disease; LUSC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg08742575 chr21:47604166 C21orf56 -0.44 -6.78 -0.35 5.39e-11 Testicular germ cell tumor; LUSC cis rs9914988 0.887 rs2070265 chr17:27075423 A/G cg14438399 chr17:27053147 TLCD1 -0.53 -5.96 -0.31 6.37e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1957429 0.901 rs3813422 chr14:65347404 G/A cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs460214 0.564 rs9979888 chr21:40022099 A/G cg05519781 chr21:40033154 ERG 0.41 5.69 0.3 2.82e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs11190604 1.000 rs11190599 chr10:102295420 C/T cg16342193 chr10:102329863 NA -0.36 -6.56 -0.34 2.08e-10 Palmitoleic acid (16:1n-7) levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23237634 chr1:154976031 ZBTB7B 0.43 6.33 0.33 7.71e-10 Triglycerides; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23000811 chr4:2464397 NA 0.4 6.0 0.31 5.04e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg17507749 chr15:85114479 UBE2QP1 0.68 8.55 0.42 4.36e-16 Schizophrenia; LUSC cis rs10876993 0.890 rs1689597 chr12:58051886 G/A cg18357645 chr12:58087776 OS9 0.51 7.64 0.39 2.33e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.88 -0.35 2.89e-11 Total body bone mineral density; LUSC cis rs7572644 0.640 rs12617113 chr2:28059937 A/G cg27432699 chr2:27873401 GPN1 0.51 6.96 0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs701145 0.537 rs357471 chr3:153896403 C/T cg17054900 chr3:154042577 DHX36 0.7 7.21 0.37 3.87e-12 Coronary artery disease; LUSC cis rs9929218 0.953 rs12930910 chr16:68762520 A/G cg02972257 chr16:68554789 NA 0.43 5.65 0.3 3.43e-8 Colorectal cancer; LUSC cis rs478304 0.903 rs546202 chr11:65510024 C/T cg27068330 chr11:65405492 SIPA1 -0.61 -8.97 -0.44 2.16e-17 Acne (severe); LUSC cis rs12543645 0.609 rs35112858 chr8:10277269 C/T cg12940923 chr8:10282607 MSRA 0.41 7.11 0.36 6.87e-12 Schizophrenia; LUSC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg17330251 chr7:94953956 PON1 -0.38 -6.17 -0.32 1.92e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.75e-10 Crohn's disease; LUSC cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg12310025 chr6:25882481 NA -0.5 -9.02 -0.44 1.46e-17 Blood metabolite levels; LUSC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.46 5.94 0.31 7.02e-9 Schizophrenia; LUSC cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.44 -0.46 6.87e-19 Chronic sinus infection; LUSC cis rs950169 0.881 rs72750843 chr15:85135783 C/T cg17507749 chr15:85114479 UBE2QP1 0.7 8.77 0.43 8.99e-17 Schizophrenia; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg08859206 chr1:53392774 SCP2 -0.54 -9.67 -0.47 1.17e-19 Monocyte count; LUSC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg22467129 chr15:76604101 ETFA -0.45 -7.17 -0.37 4.97e-12 Blood metabolite levels; LUSC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg06026331 chr20:60912101 LAMA5 0.56 6.73 0.35 7.56e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9323205 0.906 rs11629336 chr14:51686620 A/C cg23942311 chr14:51606299 NA 0.48 9.6 0.47 1.94e-19 Cancer; LUSC cis rs10489202 0.632 rs413168 chr1:168005789 C/G cg24449463 chr1:168025552 DCAF6 -0.77 -13.26 -0.59 1.58e-32 Schizophrenia; LUSC cis rs2235642 0.821 rs8051895 chr16:1602811 A/G cg26528668 chr16:1614120 IFT140 0.47 7.95 0.4 2.83e-14 Coronary artery disease; LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg03395511 chr6:291903 DUSP22 -0.5 -7.53 -0.38 4.73e-13 Menopause (age at onset); LUSC cis rs7804356 1.000 rs73069533 chr7:26892325 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.11e-9 Type 1 diabetes; LUSC cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg22782873 chr19:19639568 YJEFN3 -0.48 -6.11 -0.32 2.7e-9 Bipolar disorder; LUSC cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.34e-22 Bladder cancer; LUSC cis rs7769051 1.000 rs9493444 chr6:133125320 C/G cg07930552 chr6:133119739 C6orf192 0.84 10.61 0.5 7.57e-23 Type 2 diabetes nephropathy; LUSC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg03433033 chr1:76189801 ACADM -0.75 -11.36 -0.53 1.6e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -6.14 -0.32 2.29e-9 Schizophrenia; LUSC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.63 -8.22 -0.41 4.61e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9527 0.544 rs3781280 chr10:104863843 T/G cg04362960 chr10:104952993 NT5C2 0.62 9.75 0.47 6.07e-20 Arsenic metabolism; LUSC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg03929089 chr4:120376271 NA -0.52 -7.25 -0.37 2.87e-12 HDL cholesterol; LUSC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg04865166 chr7:105162814 PUS7 0.53 5.69 0.3 2.82e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6496667 0.533 rs886491 chr15:90993215 G/A cg10434728 chr15:90938212 IQGAP1 0.33 6.2 0.32 1.63e-9 Rheumatoid arthritis; LUSC cis rs2274273 0.840 rs28493647 chr14:55824463 T/C cg04306507 chr14:55594613 LGALS3 0.53 11.91 0.55 1.69e-27 Protein biomarker; LUSC cis rs12540874 0.895 rs4245556 chr7:50661661 C/T cg18232548 chr7:50535776 DDC -0.47 -6.6 -0.34 1.64e-10 Systemic sclerosis; LUSC cis rs11997175 0.766 rs60855034 chr8:33684732 G/A ch.8.33884649F chr8:33765107 NA 0.39 6.09 0.32 3.09e-9 Body mass index; LUSC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.24 -0.41 3.87e-15 Intelligence (multi-trait analysis); LUSC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg24733560 chr20:60626293 TAF4 0.46 8.36 0.42 1.67e-15 Body mass index; LUSC cis rs977987 0.835 rs8057535 chr16:75347941 C/T cg03315344 chr16:75512273 CHST6 0.53 10.12 0.48 3.61e-21 Dupuytren's disease; LUSC trans rs12579753 0.956 rs11115038 chr12:82214660 T/G cg07923666 chr12:49932857 KCNH3 -0.52 -6.37 -0.33 6.32e-10 Resting heart rate; LUSC cis rs9811920 0.809 rs4928150 chr3:99685991 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.4 7.5 0.38 5.71e-13 Axial length; LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.21 0.37 3.85e-12 Platelet count; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg04432617 chr1:154976216 ZBTB7B 0.45 6.31 0.33 9.06e-10 Mosquito bite size; LUSC cis rs911555 0.755 rs1116095 chr14:103931879 A/G cg24130564 chr14:104152367 KLC1 0.45 6.46 0.33 3.78e-10 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg15556689 chr8:8085844 FLJ10661 0.66 10.74 0.51 2.62e-23 Neuroticism; LUSC trans rs7618314 0.571 rs1597077 chr3:108506820 T/A cg05749855 chr16:89472771 ANKRD11 0.59 6.0 0.31 5.2e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs12980942 0.872 rs2304230 chr19:41774064 T/C cg25627403 chr19:41769009 HNRNPUL1 0.59 6.49 0.33 3.13e-10 Coronary artery disease; LUSC cis rs9837602 1.000 rs704582 chr3:99571926 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 6.12 0.32 2.62e-9 Breast cancer; LUSC cis rs13315871 1.000 rs9862969 chr3:58341917 A/G cg12435725 chr3:58293450 RPP14 -0.74 -7.81 -0.39 7.27e-14 Cholesterol, total; LUSC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg13318129 chr22:45737514 FAM118A -0.69 -8.45 -0.42 9.25e-16 Tonsillectomy; LUSC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg16060761 chr17:80687452 NA 0.41 6.26 0.32 1.21e-9 Breast cancer; LUSC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg18350739 chr11:68623251 NA -0.35 -6.38 -0.33 5.83e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs61931739 0.500 rs7137392 chr12:34447074 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.51e-34 Morning vs. evening chronotype; LUSC cis rs950776 0.518 rs11632604 chr15:78821914 T/C cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs12760731 0.565 rs34041572 chr1:178184493 T/C cg00404053 chr1:178313656 RASAL2 0.68 6.89 0.35 2.73e-11 Obesity-related traits; LUSC cis rs9314323 0.964 rs3808579 chr8:26250682 C/T cg11498726 chr8:26250323 BNIP3L -0.46 -6.81 -0.35 4.59e-11 Red cell distribution width; LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg14092988 chr3:52407081 DNAH1 0.3 5.92 0.31 8.12e-9 Bipolar disorder; LUSC cis rs34172651 0.917 rs11646987 chr16:24832408 G/T cg06028605 chr16:24865363 SLC5A11 0.46 8.38 0.42 1.45e-15 Intelligence (multi-trait analysis); LUSC cis rs11209002 0.567 rs983111 chr1:67539356 T/C cg02640540 chr1:67518911 SLC35D1 0.62 8.53 0.42 5.27e-16 Crohn's disease; LUSC cis rs7927771 0.507 rs12366244 chr11:47882130 C/A cg20307385 chr11:47447363 PSMC3 0.47 6.86 0.35 3.42e-11 Subjective well-being; LUSC cis rs12478296 0.792 rs3924263 chr2:243005167 A/C cg06360820 chr2:242988706 NA -0.82 -9.54 -0.46 3.17e-19 Obesity-related traits; LUSC cis rs362296 0.698 rs3135172 chr4:3258735 A/G cg14583973 chr4:3374767 RGS12 -0.31 -5.91 -0.31 8.59e-9 Parental longevity (mother's age at death); LUSC cis rs8078723 1.000 rs2227336 chr17:38174855 T/G cg17467752 chr17:38218738 THRA 0.78 12.57 0.57 5.92e-30 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.59 0.46 2.05e-19 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01704976 chr3:52273381 TWF2 0.41 6.28 0.32 1.04e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg24209194 chr3:40518798 ZNF619 0.47 6.58 0.34 1.84e-10 Renal cell carcinoma; LUSC cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.5 0.46 4.37e-19 Menarche (age at onset); LUSC cis rs9906944 0.678 rs56015440 chr17:47136631 C/G cg14634687 chr17:47094252 IGF2BP1 0.32 6.69 0.34 9.15e-11 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs11155671 0.530 rs2342767 chr6:150209717 C/G cg07701084 chr6:150067640 NUP43 0.46 6.93 0.35 2.23e-11 Testicular germ cell tumor; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.47 7.98 0.4 2.41e-14 Lymphocyte counts; LUSC cis rs4805272 0.512 rs7245724 chr19:29341679 C/T cg03161606 chr19:29218774 NA 0.51 5.98 0.31 5.58e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs9291683 0.597 rs11722989 chr4:10126139 A/G cg26043149 chr18:55253948 FECH -0.53 -7.78 -0.39 9e-14 Bone mineral density; LUSC cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg04317338 chr11:64019027 PLCB3 0.71 8.0 0.4 2.1e-14 Mean platelet volume; LUSC cis rs7829975 0.509 rs2945269 chr8:8115578 G/C cg08975724 chr8:8085496 FLJ10661 0.65 10.06 0.48 5.65e-21 Mood instability; LUSC cis rs7914558 0.646 rs7100709 chr10:104649729 A/C cg05855489 chr10:104503620 C10orf26 0.43 5.82 0.3 1.42e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.45 -0.46 6.09e-19 Electroencephalogram traits; LUSC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs7119 0.717 rs11632729 chr15:77722006 G/A cg27398640 chr15:77910606 LINGO1 -0.28 -5.73 -0.3 2.19e-8 Type 2 diabetes; LUSC cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.47 0.42 8.05e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7223966 1.000 rs8073373 chr17:61703320 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.46 0.38 7.44e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC cis rs7769051 0.522 rs6934190 chr6:133116664 G/A cg22852734 chr6:133119734 C6orf192 1.34 10.6 0.5 8.1e-23 Type 2 diabetes nephropathy; LUSC cis rs865483 1.000 rs865483 chr17:35851177 A/C cg06716730 chr17:35851459 DUSP14 0.29 6.33 0.33 7.77e-10 Monocyte count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04709120 chr10:74451858 CCDC109A -0.58 -6.97 -0.36 1.68e-11 Bipolar disorder and schizophrenia; LUSC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg11632617 chr15:75315747 PPCDC -0.51 -6.69 -0.34 9.31e-11 Blood trace element (Zn levels); LUSC cis rs939658 0.935 rs4778651 chr15:79447810 G/A cg17916960 chr15:79447300 NA -0.53 -10.56 -0.5 1.09e-22 Refractive error; LUSC cis rs722599 0.748 rs61978932 chr14:75342954 C/T cg08847533 chr14:75593920 NEK9 -0.46 -6.64 -0.34 1.28e-10 IgG glycosylation; LUSC cis rs7980687 0.678 rs7132277 chr12:123593382 C/T cg00376283 chr12:123451042 ABCB9 -0.71 -7.67 -0.39 1.95e-13 Height;Educational attainment;Head circumference (infant); LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg18099408 chr3:52552593 STAB1 -0.41 -7.03 -0.36 1.15e-11 Bipolar disorder; LUSC cis rs28619038 1 rs28619038 chr15:64642517 C/A cg02848875 chr15:64387786 SNX1 -0.41 -5.92 -0.31 7.78e-9 Myeloid white cell count; LUSC cis rs8067545 0.750 rs4924803 chr17:19991806 C/T cg13482628 chr17:19912719 NA 0.47 7.75 0.39 1.09e-13 Schizophrenia; LUSC cis rs1372520 0.748 rs2737002 chr4:90753180 A/G cg15133208 chr4:90757351 SNCA -0.57 -8.73 -0.43 1.22e-16 Neuroticism; LUSC cis rs722599 0.748 rs731165 chr14:75352555 T/C cg06637938 chr14:75390232 RPS6KL1 -0.42 -6.15 -0.32 2.18e-9 IgG glycosylation; LUSC cis rs7824557 0.510 rs4841524 chr8:11243126 C/G cg12940923 chr8:10282607 MSRA -0.32 -5.66 -0.3 3.34e-8 Retinal vascular caliber; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg21829265 chr6:56911139 KIAA1586 0.36 6.41 0.33 5.09e-10 Tuberculosis; LUSC cis rs9300255 0.602 rs10846486 chr12:123709927 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs8114671 0.562 rs4911450 chr20:33512406 C/T cg07148914 chr20:33460835 GGT7 0.56 8.53 0.42 5.25e-16 Height; LUSC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.84 0.35 3.83e-11 Intelligence (multi-trait analysis); LUSC cis rs4077515 0.967 rs11794847 chr9:139271747 G/A cg14169450 chr9:139327907 INPP5E 0.43 7.55 0.38 4.28e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs500891 0.525 rs12190282 chr6:84056328 A/G cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.08e-14 Platelet-derived growth factor BB levels; LUSC cis rs7937682 0.889 rs497111 chr11:111499512 G/A cg19812747 chr11:111475976 SIK2 -0.52 -7.34 -0.37 1.67e-12 Primary sclerosing cholangitis; LUSC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg09367891 chr1:107599246 PRMT6 0.52 8.15 0.41 7.44e-15 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg14668632 chr7:2872130 GNA12 -0.45 -6.79 -0.35 5.1e-11 Height; LUSC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.46 -0.53 7.13e-26 Mean corpuscular volume; LUSC cis rs11785400 0.793 rs4430071 chr8:143737680 T/C cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs2046867 0.818 rs7637138 chr3:72910886 A/G cg25664220 chr3:72788482 NA -0.61 -10.13 -0.48 3.31e-21 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1595825 1.000 rs1440087 chr2:198871476 G/C cg00982548 chr2:198649783 BOLL -0.51 -6.31 -0.33 8.95e-10 Ulcerative colitis; LUSC cis rs6693567 0.565 rs1313570 chr1:150342642 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.04 0.36 1.11e-11 Migraine; LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg08219700 chr8:58056026 NA 0.72 8.29 0.41 2.9e-15 Developmental language disorder (linguistic errors); LUSC trans rs208520 0.954 rs12190073 chr6:66983740 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs7819412 0.522 rs11776603 chr8:11020313 G/T cg21775007 chr8:11205619 TDH -0.54 -7.23 -0.37 3.21e-12 Triglycerides; LUSC cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg15395560 chr15:45543142 SLC28A2 0.33 5.66 0.3 3.25e-8 Uric acid levels; LUSC cis rs13031619 0.607 rs13001751 chr2:3695870 A/G cg00999904 chr2:3704751 ALLC -0.34 -6.26 -0.32 1.18e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs7829975 0.714 rs59046059 chr8:8670736 C/A cg21775007 chr8:11205619 TDH 0.44 6.26 0.32 1.18e-9 Mood instability; LUSC cis rs6690583 0.562 rs12024977 chr1:85531051 A/C cg11262906 chr1:85462892 MCOLN2 0.67 6.43 0.33 4.45e-10 Serum sulfate level; LUSC cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.26e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg00071950 chr4:10020882 SLC2A9 0.64 10.42 0.5 3.3e-22 Bone mineral density; LUSC cis rs459571 0.629 rs441233 chr9:136876021 A/G cg13789015 chr9:136890014 NCRNA00094 -0.55 -9.81 -0.47 4.02e-20 Platelet distribution width; LUSC cis rs4900538 0.787 rs11704 chr14:102808655 C/G cg18135206 chr14:102964638 TECPR2 0.96 18.01 0.7 3.76e-51 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4499344 0.519 rs259226 chr19:33134965 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.93 13.74 0.6 2.35e-34 Mean platelet volume; LUSC cis rs61931739 0.817 rs592857 chr12:34197673 T/G cg06521331 chr12:34319734 NA -0.35 -6.01 -0.31 4.82e-9 Morning vs. evening chronotype; LUSC cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg24733560 chr20:60626293 TAF4 0.44 8.16 0.41 6.76e-15 Body mass index; LUSC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg09365446 chr1:150670422 GOLPH3L -0.54 -8.45 -0.42 9.05e-16 Tonsillectomy; LUSC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg23719950 chr11:63933701 MACROD1 -0.62 -8.07 -0.4 1.24e-14 Mean platelet volume; LUSC cis rs11039100 0.527 rs2047460 chr11:5781159 A/G cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs62400317 0.826 rs11963924 chr6:45306562 C/T cg18551225 chr6:44695536 NA -0.45 -7.44 -0.38 8.38e-13 Total body bone mineral density; LUSC cis rs262150 0.501 rs2730206 chr7:158815173 G/C cg04111992 chr7:158790115 NA -0.44 -6.99 -0.36 1.46e-11 Facial morphology (factor 20); LUSC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg21138405 chr5:131827807 IRF1 0.55 11.18 0.52 7.08e-25 Asthma (sex interaction); LUSC cis rs11098499 0.865 rs1112817 chr4:120297800 T/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg22875332 chr1:76189707 ACADM 0.85 15.22 0.64 4.04e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs56399783 0.901 rs11761804 chr7:2792524 C/T cg14895029 chr7:2775587 GNA12 0.55 5.72 0.3 2.41e-8 Childhood ear infection; LUSC cis rs62400317 0.859 rs10948212 chr6:45156933 A/C cg20913747 chr6:44695427 NA -0.48 -7.63 -0.39 2.56e-13 Total body bone mineral density; LUSC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg03806693 chr22:41940476 POLR3H -0.96 -12.95 -0.58 2.42e-31 Vitiligo; LUSC cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg08999081 chr20:33150536 PIGU 0.44 8.2 0.41 5.32e-15 Coronary artery disease; LUSC cis rs72781680 0.716 rs2712050 chr2:24059408 A/C cg08917208 chr2:24149416 ATAD2B 0.6 6.89 0.35 2.84e-11 Lymphocyte counts; LUSC cis rs9399135 0.967 rs9389254 chr6:135330709 C/T cg22676075 chr6:135203613 NA 0.48 7.48 0.38 6.5e-13 Red blood cell count; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg20887711 chr4:1340912 KIAA1530 -0.48 -7.25 -0.37 2.9e-12 Obesity-related traits; LUSC cis rs859767 0.501 rs4954160 chr2:135431692 A/C cg12500956 chr2:135428796 TMEM163 -0.29 -6.98 -0.36 1.6e-11 Neuroticism; LUSC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg18196295 chr10:418757 DIP2C 0.42 6.82 0.35 4.32e-11 Psychosis in Alzheimer's disease; LUSC cis rs7584330 0.697 rs60278044 chr2:238357118 A/G cg14458575 chr2:238380390 NA 0.73 12.59 0.57 5.23e-30 Prostate cancer; LUSC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg14440974 chr22:39074834 NA -0.36 -6.07 -0.32 3.43e-9 Menopause (age at onset); LUSC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.77 -0.3 1.77e-8 Depression; LUSC cis rs10871290 0.881 rs7498574 chr16:74472661 A/G cg01733217 chr16:74700730 RFWD3 -0.62 -8.95 -0.44 2.47e-17 Breast cancer; LUSC cis rs6460942 0.908 rs117451929 chr7:12265149 A/T cg06484146 chr7:12443880 VWDE -0.61 -6.47 -0.33 3.48e-10 Coronary artery disease; LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.45 6.7 0.34 8.95e-11 Platelet count; LUSC cis rs412000 0.560 rs4793583 chr17:56451407 A/C cg05425664 chr17:57184151 TRIM37 0.56 9.05 0.44 1.24e-17 Primary tooth development (time to first tooth eruption); LUSC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.43 -0.38 9e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6998277 1.000 rs34217554 chr8:103646352 T/C cg10187029 chr8:103597600 NA 0.65 8.46 0.42 8.6e-16 Migraine; LUSC cis rs9469578 0.681 rs78748610 chr6:33714412 T/C cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs7824557 0.527 rs11785394 chr8:11238029 C/T cg21775007 chr8:11205619 TDH -0.66 -10.23 -0.49 1.46e-21 Retinal vascular caliber; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg00149659 chr3:10157352 C3orf10 0.91 13.04 0.58 1.03e-31 Alzheimer's disease; LUSC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -8.19 -0.41 5.67e-15 Prostate cancer; LUSC cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -7.63 -0.39 2.54e-13 Schizophrenia; LUSC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg16414030 chr3:133502952 NA -0.45 -7.0 -0.36 1.42e-11 Iron status biomarkers; LUSC cis rs4363385 0.747 rs4845507 chr1:152968414 T/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 3.97e-14 Inflammatory skin disease; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg23034840 chr1:205782522 SLC41A1 0.67 10.04 0.48 6.73e-21 Menarche (age at onset); LUSC cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg23796481 chr11:64053134 BAD;GPR137 0.52 8.14 0.41 7.67e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg18206459 chr2:208030726 KLF7 -0.39 -6.26 -0.32 1.19e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.55 0.34 2.13e-10 Rheumatoid arthritis; LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 20.42 0.75 1.03e-60 Prudent dietary pattern; LUSC cis rs7582180 0.715 rs920270 chr2:100917961 T/C cg08017756 chr2:100939284 LONRF2 -0.43 -8.03 -0.4 1.69e-14 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg08470875 chr2:26401718 FAM59B 0.69 8.08 0.4 1.19e-14 Gut microbiome composition (summer); LUSC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg20887711 chr4:1340912 KIAA1530 0.54 8.65 0.43 2.24e-16 Longevity; LUSC cis rs1127311 0.901 rs11264223 chr1:154565519 G/A cg17218026 chr1:154582156 ADAR 0.57 10.15 0.49 2.89e-21 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs11992162 0.967 rs10088415 chr8:11830825 A/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.02 -0.4 1.86e-14 Monocyte count; LUSC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.84 0.39 5.97e-14 Bipolar disorder; LUSC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg01657329 chr11:68192670 LRP5 0.45 7.2 0.37 4.04e-12 Total body bone mineral density; LUSC cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg08085267 chr17:45401833 C17orf57 -0.51 -7.95 -0.4 2.86e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg14552801 chr7:65878734 NA 0.38 5.93 0.31 7.76e-9 Aortic root size; LUSC cis rs6087771 0.714 rs6058259 chr20:30235302 A/G cg18721089 chr20:30220636 NA -0.33 -5.81 -0.3 1.44e-8 Subcortical brain region volumes;Putamen volume; LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.56 8.37 0.42 1.63e-15 Lymphocyte counts; LUSC cis rs11051970 0.636 rs325424 chr12:32570193 C/T cg02745156 chr12:32552066 NA 0.39 7.08 0.36 8.63e-12 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs3749237 0.964 rs13084243 chr3:49821878 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.5 6.82 0.35 4.2e-11 Resting heart rate; LUSC cis rs6426558 0.537 rs6682642 chr1:227244600 G/T cg10327440 chr1:227177885 CDC42BPA 0.57 8.24 0.41 4e-15 Neutrophil percentage of white cells; LUSC cis rs238295 0.805 rs6053486 chr20:5530767 T/G cg15842884 chr20:5591925 RP5-1022P6.2 -0.43 -5.84 -0.3 1.25e-8 Occipital cortical area (total cortical area interaction); LUSC trans rs7893279 0.822 rs11014185 chr10:18714347 T/A cg01840055 chr3:141338555 NA 0.5 6.04 0.31 4.02e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.76 0.47 5.68e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9467773 0.620 rs2504600 chr6:26648334 C/A cg09904177 chr6:26538194 HMGN4 0.66 11.7 0.54 1.01e-26 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20583797 chr15:86338184 KLHL25 0.42 5.98 0.31 5.72e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2742234 0.955 rs2435385 chr10:43665750 A/G cg15436174 chr10:43711423 RASGEF1A -0.37 -6.35 -0.33 7.06e-10 Hirschsprung disease; LUSC cis rs6430585 0.583 rs59213715 chr2:136646582 A/C cg07169764 chr2:136633963 MCM6 1.16 17.2 0.69 6.54e-48 Corneal structure; LUSC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg09267113 chr7:98030324 BAIAP2L1 0.38 5.78 0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg22903471 chr2:27725779 GCKR -0.41 -7.07 -0.36 9.02e-12 Total body bone mineral density; LUSC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.69 -0.34 9.39e-11 Mean platelet volume; LUSC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.78 0.47 5.09e-20 Bipolar disorder; LUSC cis rs7904368 0.806 rs7899853 chr10:16857603 A/T cg14835575 chr10:16859367 RSU1 0.78 10.21 0.49 1.8e-21 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs2463822 1.000 rs72921498 chr11:62113090 C/T cg06239285 chr11:62104954 ASRGL1 -0.98 -10.73 -0.51 2.8e-23 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9611519 0.780 rs9611546 chr22:41698542 C/G cg03806693 chr22:41940476 POLR3H -0.63 -9.25 -0.45 2.75e-18 Neuroticism; LUSC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg09796270 chr17:17721594 SREBF1 -0.4 -7.1 -0.36 7.57e-12 Total body bone mineral density; LUSC cis rs7829975 0.626 rs332040 chr8:8730488 G/A cg14343924 chr8:8086146 FLJ10661 0.46 6.38 0.33 6.04e-10 Mood instability; LUSC cis rs12701220 0.817 rs59471534 chr7:1085224 G/A cg04025307 chr7:1156635 C7orf50 0.45 5.98 0.31 5.66e-9 Bronchopulmonary dysplasia; LUSC cis rs7178572 0.889 rs7171448 chr15:77832316 C/G cg22256960 chr15:77711686 NA -0.52 -8.43 -0.42 1.04e-15 Type 2 diabetes; LUSC cis rs12980942 1.000 rs7257742 chr19:41827352 G/T cg25627403 chr19:41769009 HNRNPUL1 0.57 6.15 0.32 2.17e-9 Coronary artery disease; LUSC cis rs9902453 0.765 rs3102555 chr17:28044101 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.19 0.52 6.82e-25 Coffee consumption (cups per day); LUSC cis rs1941023 0.584 rs2233252 chr11:60157107 T/G cg08716584 chr11:60157161 MS4A7 -0.65 -12.23 -0.56 1.11e-28 Congenital heart disease (maternal effect); LUSC trans rs7746199 0.736 rs13193542 chr6:27702425 G/T cg01620082 chr3:125678407 NA -0.78 -7.29 -0.37 2.28e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg06740227 chr12:86229804 RASSF9 0.44 7.12 0.36 6.82e-12 Major depressive disorder; LUSC cis rs708547 0.836 rs1315005 chr4:57858237 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.69 9.65 0.47 1.37e-19 Response to bleomycin (chromatid breaks); LUSC cis rs1107366 1.000 rs1107366 chr3:125904165 A/G cg20988073 chr3:125900093 ALDH1L1 -0.31 -6.25 -0.32 1.26e-9 Metabolite levels; LUSC cis rs9929218 0.817 rs3114405 chr16:68722377 G/A cg02972257 chr16:68554789 NA 0.44 5.67 0.3 3.14e-8 Colorectal cancer; LUSC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg17554472 chr22:41940697 POLR3H -0.48 -5.87 -0.31 1.04e-8 Vitiligo; LUSC cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 -0.61 -11.13 -0.52 1.07e-24 Bone mineral density (spine);Bone mineral density; LUSC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg18876405 chr7:65276391 NA 0.56 8.96 0.44 2.33e-17 Aortic root size; LUSC cis rs7818345 1.000 rs7823194 chr8:19292528 C/T cg11303988 chr8:19266685 CSGALNACT1 0.38 7.26 0.37 2.72e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg08847533 chr14:75593920 NEK9 0.84 15.5 0.65 3.28e-41 Height; LUSC cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg23583168 chr7:148888333 NA -0.83 -15.38 -0.64 9.88e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9296092 0.560 rs3846853 chr6:33528194 C/G cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs4927850 0.958 rs1975582 chr3:195751439 G/T cg16724585 chr3:197361211 NA -0.6 -8.43 -0.42 1.02e-15 Pancreatic cancer; LUSC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg24675658 chr1:53192096 ZYG11B -0.57 -8.84 -0.44 5.43e-17 Monocyte count; LUSC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg20406979 chr6:167373233 NA -0.26 -6.16 -0.32 2.1e-9 Crohn's disease; LUSC cis rs12579753 0.871 rs12822050 chr12:82183041 C/T cg07988820 chr12:82153109 PPFIA2 -0.4 -5.72 -0.3 2.32e-8 Resting heart rate; LUSC cis rs28619038 1 rs28619038 chr15:64642517 C/A cg08069370 chr15:64387884 SNX1 -0.56 -6.23 -0.32 1.44e-9 Myeloid white cell count; LUSC trans rs61931739 0.817 rs11053071 chr12:34201400 A/G cg13010199 chr12:38710504 ALG10B 0.41 6.62 0.34 1.46e-10 Morning vs. evening chronotype; LUSC cis rs7715806 0.500 rs10515213 chr5:74980572 C/T cg19683494 chr5:74908142 NA -0.57 -7.83 -0.39 6.34e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2200578 0.786 rs57656020 chr2:99799378 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.4 0.33 5.21e-10 IgG glycosylation; LUSC cis rs10463316 0.894 rs13357969 chr5:150751557 A/G cg03212797 chr5:150827313 SLC36A1 -0.47 -7.09 -0.36 8.25e-12 Metabolite levels (Pyroglutamine); LUSC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg05368731 chr17:41323189 NBR1 -0.84 -14.33 -0.62 1.19e-36 Menopause (age at onset); LUSC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.63e-16 Lung cancer; LUSC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.82 -0.39 7.18e-14 Crohn's disease; LUSC cis rs9942416 0.660 rs4704234 chr5:75001432 A/G cg19683494 chr5:74908142 NA 0.41 6.4 0.33 5.28e-10 Age-related disease endophenotypes; LUSC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11644478 chr21:40555479 PSMG1 -0.61 -9.61 -0.47 1.88e-19 Menarche (age at onset); LUSC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg05234568 chr11:5960015 NA -0.6 -8.72 -0.43 1.35e-16 DNA methylation (variation); LUSC cis rs3820928 0.874 rs13393894 chr2:227880543 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.8 -0.39 7.97e-14 Pulmonary function; LUSC trans rs4800353 0.929 rs899640 chr18:19607986 T/G cg01841828 chr16:69166849 CHTF8;CIRH1A -0.58 -6.02 -0.31 4.53e-9 Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs2414856 0.510 rs72756997 chr15:64608662 G/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg11905131 chr22:24372483 LOC391322 -0.54 -8.54 -0.42 4.83e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6961069 0.774 rs1054516 chr7:80284942 T/C cg04458919 chr7:80252533 CD36 0.34 6.04 0.31 4.21e-9 Platelet count; LUSC cis rs2120019 0.507 rs4886642 chr15:75228846 T/C cg17294928 chr15:75287854 SCAMP5 -0.76 -8.79 -0.43 7.81e-17 Blood trace element (Zn levels); LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg16584290 chr5:462447 EXOC3 -0.42 -7.53 -0.38 4.92e-13 Cystic fibrosis severity; LUSC cis rs7647973 0.710 rs11130208 chr3:49615624 G/T cg13072238 chr3:49761600 GMPPB -0.69 -8.19 -0.41 5.44e-15 Menarche (age at onset); LUSC cis rs926938 0.527 rs58658580 chr1:115539726 A/G cg01522456 chr1:115632236 TSPAN2 -0.4 -6.21 -0.32 1.57e-9 Autism; LUSC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.87 -0.35 3.19e-11 Intelligence (multi-trait analysis); LUSC trans rs12554020 0.892 rs6479494 chr9:96330499 C/T cg06165706 chr14:101347143 RTL1;MIR431;MIR433 -0.38 -6.01 -0.31 4.76e-9 Schizophrenia; LUSC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg06808227 chr14:105710500 BRF1 -0.65 -9.9 -0.48 1.97e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs78572108 0.858 rs4952580 chr2:42266740 G/C cg00607755 chr2:42274082 PKDCC 0.35 6.11 0.32 2.79e-9 Total body bone mineral density; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.53 -8.08 -0.4 1.18e-14 Lymphocyte counts; LUSC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg23298862 chr7:158159286 PTPRN2 -0.32 -5.79 -0.3 1.59e-8 Response to amphetamines; LUSC cis rs7246657 0.943 rs10415937 chr19:37830064 T/G cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs11585357 0.895 rs72633828 chr1:17632251 G/A cg08277548 chr1:17600880 PADI3 -0.59 -6.17 -0.32 1.92e-9 Hair shape; LUSC cis rs2290416 0.892 rs62522168 chr8:144679776 G/A cg14809332 chr8:144654887 C8orf73 0.54 6.51 0.34 2.83e-10 Attention deficit hyperactivity disorder; LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.79 0.65 2.34e-42 Platelet count; LUSC cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg10523860 chr14:103875565 MARK3 -0.37 -5.9 -0.31 9.07e-9 Body mass index; LUSC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg17264618 chr3:40429014 ENTPD3 0.33 7.02 0.36 1.28e-11 Renal cell carcinoma; LUSC cis rs9902453 1.000 rs11080114 chr17:28407287 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.59 -0.43 3.42e-16 Coffee consumption (cups per day); LUSC cis rs7824557 0.602 rs11784544 chr8:11204503 G/C cg21775007 chr8:11205619 TDH 0.82 13.79 0.6 1.53e-34 Retinal vascular caliber; LUSC cis rs9359856 0.913 rs9362665 chr6:90309844 C/T cg13799429 chr6:90582589 CASP8AP2 0.58 6.48 0.33 3.2e-10 Bipolar disorder; LUSC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg19418458 chr7:158789849 NA -0.5 -8.14 -0.41 8.12e-15 Facial morphology (factor 20); LUSC cis rs708547 0.624 rs1277284 chr4:57855361 T/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.56 8.44 0.42 9.54e-16 Response to bleomycin (chromatid breaks); LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.13 0.32 2.44e-9 Bipolar disorder; LUSC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg22968622 chr17:43663579 NA -0.78 -12.08 -0.55 3.97e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs6601327 0.606 rs4841203 chr8:9582730 A/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.58 -0.34 1.83e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg16850897 chr7:100343110 ZAN -0.52 -7.84 -0.39 5.94e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs7746199 0.736 rs34573979 chr6:27480526 C/T cg06606381 chr12:133084897 FBRSL1 -0.99 -9.31 -0.45 1.78e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs2277425 0.755 rs2277424 chr13:111522420 A/G cg04513422 chr13:111522314 C13orf29 -0.52 -6.33 -0.33 7.75e-10 Sitting height ratio; LUSC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg20406979 chr6:167373233 NA -0.26 -6.09 -0.32 3.18e-9 Crohn's disease; LUSC cis rs4285028 0.699 rs1920298 chr3:121597888 T/C cg11130432 chr3:121712080 ILDR1 -0.62 -9.4 -0.46 9.2e-19 Multiple sclerosis; LUSC cis rs8060686 0.641 rs113502835 chr16:68238965 A/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.94 -0.31 7.01e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg04518342 chr5:131593106 PDLIM4 0.44 8.13 0.41 8.44e-15 Breast cancer; LUSC trans rs67133203 0.851 rs11169667 chr12:51403088 G/A cg17484237 chr5:156536107 HAVCR2 0.44 6.02 0.31 4.52e-9 Urinary tract infection frequency; LUSC trans rs1997103 1.000 rs2177803 chr7:55410773 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11644478 chr21:40555479 PSMG1 -0.76 -13.43 -0.59 3.44e-33 Cognitive function; LUSC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg06145435 chr7:1022769 CYP2W1 0.3 6.43 0.33 4.31e-10 Longevity;Endometriosis; LUSC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.08 0.32 3.27e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg00071950 chr4:10020882 SLC2A9 -0.53 -9.0 -0.44 1.77e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.47 7.75 0.39 1.15e-13 Vitiligo; LUSC cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg00376283 chr12:123451042 ABCB9 0.7 9.19 0.45 4.24e-18 Neutrophil percentage of white cells; LUSC cis rs709400 0.663 rs72708893 chr14:103929535 G/A cg10523860 chr14:103875565 MARK3 -0.37 -5.82 -0.3 1.4e-8 Body mass index; LUSC cis rs4595586 0.525 rs4768531 chr12:39417754 T/A cg13010199 chr12:38710504 ALG10B 0.45 6.4 0.33 5.12e-10 Morning vs. evening chronotype; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg23131131 chr22:24373011 LOC391322 -0.41 -6.05 -0.31 3.84e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9560113 0.959 rs4771756 chr13:112176083 T/G cg14154082 chr13:112174009 NA 0.39 8.01 0.4 1.89e-14 Menarche (age at onset); LUSC cis rs12410462 0.581 rs7547204 chr1:227560909 C/T cg04117972 chr1:227635322 NA 0.61 6.56 0.34 2e-10 Major depressive disorder; LUSC cis rs1550582 0.548 rs11538239 chr8:135490539 A/G cg17885191 chr8:135476712 NA -0.94 -13.8 -0.6 1.31e-34 Educational attainment; LUSC cis rs2742417 0.565 rs2673031 chr3:45756986 A/G cg04837898 chr3:45731254 SACM1L -0.43 -7.01 -0.36 1.34e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs57590327 0.527 rs9845467 chr3:81614473 G/A cg07356753 chr3:81810745 GBE1 -0.47 -6.31 -0.33 8.95e-10 Extraversion; LUSC cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.52 -7.82 -0.39 6.9e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10911232 0.507 rs10797817 chr1:182999136 G/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs80130819 0.748 rs1387255 chr12:48648943 C/T cg24011408 chr12:48396354 COL2A1 0.47 5.89 0.31 9.22e-9 Prostate cancer; LUSC cis rs765787 0.530 rs12917187 chr15:45538297 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg12310025 chr6:25882481 NA 0.41 6.84 0.35 3.69e-11 Intelligence (multi-trait analysis); LUSC trans rs970548 0.606 rs12355888 chr10:45931564 G/T cg14222797 chr10:16859974 RSU1 -0.65 -6.21 -0.32 1.56e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs593982 1.000 rs118030231 chr11:65501905 G/A cg08755490 chr11:65554678 OVOL1 -1.46 -15.35 -0.64 1.35e-40 Atopic dermatitis; LUSC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg05347473 chr6:146136440 FBXO30 0.63 10.52 0.5 1.52e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs9616064 0.531 rs66909472 chr22:47050210 G/A cg25730555 chr22:47059586 GRAMD4 0.45 7.07 0.36 9.04e-12 Urate levels in obese individuals; LUSC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg07636037 chr3:49044803 WDR6 0.44 6.36 0.33 6.58e-10 Resting heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06445916 chr8:42268472 NA 0.51 6.96 0.36 1.85e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs193541 0.632 rs154512 chr5:122195040 T/C cg19077854 chr5:122220652 SNX24 0.37 7.84 0.39 5.91e-14 Glucose homeostasis traits; LUSC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg10883421 chr6:151773342 RMND1;C6orf211 0.67 11.26 0.52 3.93e-25 Menarche (age at onset); LUSC cis rs2197308 0.765 rs7295711 chr12:37903631 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs2730245 0.527 rs1188971 chr7:158664463 G/T cg24397884 chr7:158709396 WDR60 0.77 8.58 0.43 3.56e-16 Height; LUSC cis rs9341835 0.740 rs10755410 chr6:64150689 G/A cg03326410 chr6:64151739 NA -0.37 -6.13 -0.32 2.53e-9 Schizophrenia; LUSC cis rs826838 1.000 rs10880826 chr12:38672787 G/C cg13010199 chr12:38710504 ALG10B 0.68 10.87 0.51 9.2e-24 Heart rate; LUSC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg21862992 chr11:68658383 NA 0.5 8.13 0.41 8.64e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs11098499 0.618 rs35265692 chr4:120325135 T/C cg25214090 chr10:38739885 LOC399744 0.54 7.92 0.4 3.59e-14 Corneal astigmatism; LUSC cis rs8017423 0.647 rs4904674 chr14:90817412 G/A cg04374321 chr14:90722782 PSMC1 -0.43 -6.6 -0.34 1.65e-10 Mortality in heart failure; LUSC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg12639453 chr1:2035780 PRKCZ 0.29 6.05 0.31 3.9e-9 Height; LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.32 0.56 5.39e-29 Prudent dietary pattern; LUSC trans rs7824557 0.564 rs11781637 chr8:11214972 C/T cg08975724 chr8:8085496 FLJ10661 -0.51 -7.55 -0.38 4.24e-13 Retinal vascular caliber; LUSC trans rs2910490 1.000 rs2910490 chr5:56922085 A/G cg24648061 chr7:107114615 COG5;GPR22 -0.34 -6.08 -0.32 3.34e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4363385 0.818 rs1415966 chr1:153002864 A/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg24829409 chr8:58192753 C8orf71 -0.51 -6.06 -0.31 3.7e-9 Developmental language disorder (linguistic errors); LUSC cis rs11679564 0.714 rs4389320 chr2:37172531 T/C cg14987922 chr2:37194071 STRN 0.63 9.57 0.46 2.57e-19 Immature fraction of reticulocytes; LUSC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg25767906 chr1:53392781 SCP2 -0.39 -6.85 -0.35 3.62e-11 Monocyte count; LUSC cis rs9467773 0.595 rs3846845 chr6:26444915 G/A cg05738196 chr6:26577821 NA -0.52 -7.73 -0.39 1.28e-13 Intelligence (multi-trait analysis); LUSC cis rs2282032 1.000 rs75722521 chr14:90760478 T/C cg14092571 chr14:90743983 NA 0.53 6.81 0.35 4.52e-11 Longevity; LUSC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg22907277 chr7:1156413 C7orf50 0.7 10.29 0.49 9.45e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4820539 0.966 rs5751587 chr22:23470090 G/A cg21100191 chr22:23484243 RTDR1 0.92 16.16 0.66 8.69e-44 Bone mineral density; LUSC cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg18132916 chr6:79620363 NA 0.37 5.65 0.3 3.4e-8 Intelligence (multi-trait analysis); LUSC cis rs4144743 1.000 rs66738981 chr17:45325538 T/A cg18085866 chr17:45331354 ITGB3 -0.73 -7.75 -0.39 1.12e-13 Body mass index; LUSC cis rs7824557 0.591 rs2572452 chr8:11228254 C/T cg21775007 chr8:11205619 TDH -0.71 -11.79 -0.54 4.5e-27 Retinal vascular caliber; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg05621195 chr12:123237031 DENR 0.39 6.04 0.31 4e-9 Triglycerides; LUSC trans rs61931739 0.534 rs11052991 chr12:34059018 G/T cg26384229 chr12:38710491 ALG10B -0.66 -10.52 -0.5 1.5e-22 Morning vs. evening chronotype; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg03853227 chr12:107487365 CRY1 0.62 5.98 0.31 5.84e-9 Body mass index; LUSC cis rs56283067 0.887 rs10948171 chr6:44761028 C/T cg18551225 chr6:44695536 NA -0.48 -7.65 -0.39 2.13e-13 Total body bone mineral density; LUSC cis rs10992471 0.528 rs10761158 chr9:95205322 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.24 -0.32 1.36e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7572644 0.699 rs13411592 chr2:28098724 G/A cg27432699 chr2:27873401 GPN1 -0.51 -6.94 -0.36 2.04e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg25036284 chr2:26402008 FAM59B -0.68 -10.03 -0.48 7.02e-21 Gut microbiome composition (summer); LUSC cis rs7119038 0.865 rs11217044 chr11:118696022 T/C cg19308663 chr11:118741387 NA 0.35 6.18 0.32 1.83e-9 Sjögren's syndrome; LUSC cis rs2486288 0.656 rs11632419 chr15:45557456 C/A cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.6 -0.5 8.24e-23 Glomerular filtration rate; LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg16647868 chr5:131706066 SLC22A5 0.38 5.89 0.31 9.29e-9 Breast cancer; LUSC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg11890956 chr21:40555474 PSMG1 0.8 10.13 0.48 3.2e-21 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24655899 chr17:79519568 C17orf70 -0.4 -6.0 -0.31 5.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6076065 0.723 rs2251145 chr20:23399998 G/A cg11657817 chr20:23433608 CST11 0.43 7.92 0.4 3.54e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs11792861 0.505 rs12377869 chr9:111907803 C/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.48 7.71 0.39 1.41e-13 Menarche (age at onset); LUSC cis rs9747201 0.962 rs62079995 chr17:80076624 C/T cg18209359 chr17:80159595 CCDC57 0.39 6.38 0.33 6.04e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10992471 0.603 rs7868013 chr9:95240173 G/A cg14631576 chr9:95140430 CENPP -0.34 -6.17 -0.32 1.97e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12810548 chr4:53579237 SNORA26;KIAA0114 0.44 6.93 0.35 2.14e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7759001 0.857 rs4713092 chr6:27363898 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs977987 0.671 rs9922008 chr16:75335406 T/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.45 -0.33 3.91e-10 Dupuytren's disease; LUSC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.17 -0.32 2.03e-9 Menopause (age at onset); LUSC cis rs17253792 0.822 rs10135426 chr14:56054644 A/G cg01858014 chr14:56050164 KTN1 -0.86 -7.18 -0.37 4.47e-12 Putamen volume; LUSC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.6 -0.34 1.61e-10 Alzheimer's disease (late onset); LUSC cis rs155346 1.000 rs265156 chr5:139386659 C/T cg01090482 chr5:139365336 NRG2 -0.38 -6.24 -0.32 1.34e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg09436375 chr6:42928200 GNMT 0.28 6.28 0.32 1.08e-9 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14683138 chr19:10781796 ILF3 -0.63 -6.06 -0.31 3.64e-9 Cognitive performance; LUSC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg27165867 chr14:105738592 BRF1 -0.55 -8.25 -0.41 3.72e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg23711669 chr6:146136114 FBXO30 0.75 11.93 0.55 1.44e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs6665290 0.935 rs1929862 chr1:227199718 G/A cg10327440 chr1:227177885 CDC42BPA -1.23 -39.56 -0.91 4.37e-128 Myeloid white cell count; LUSC cis rs61931739 0.534 rs4365131 chr12:34053308 T/C cg06521331 chr12:34319734 NA -0.51 -8.35 -0.42 1.85e-15 Morning vs. evening chronotype; LUSC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg18681998 chr4:17616180 MED28 0.86 16.36 0.67 1.31e-44 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7481584 0.669 rs12793371 chr11:3034709 A/G cg05729581 chr11:3078854 CARS 0.42 6.25 0.32 1.28e-9 Calcium levels; LUSC cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg19875535 chr5:140030758 IK -0.54 -8.91 -0.44 3.39e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs9672608 0.687 rs5019044 chr15:78796282 T/A cg24631222 chr15:78858424 CHRNA5 0.71 8.95 0.44 2.46e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg04315214 chr1:2043799 PRKCZ 0.47 9.93 0.48 1.51e-20 Height; LUSC cis rs11971779 0.680 rs4732373 chr7:139086535 T/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs870825 0.616 rs2003994 chr4:185636568 G/T cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC cis rs7267979 1.000 rs2500448 chr20:25404027 A/C cg08601574 chr20:25228251 PYGB -0.43 -6.61 -0.34 1.52e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1459104 0.641 rs4454742 chr11:54840592 A/T cg03929089 chr4:120376271 NA 0.74 6.42 0.33 4.54e-10 Body mass index; LUSC cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg23158103 chr7:148848205 ZNF398 0.5 8.23 0.41 4.25e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs137603 0.644 rs470082 chr22:39715140 C/T cg17798944 chr22:39715225 SNORD43;RPL3 -0.5 -8.03 -0.4 1.72e-14 Primary biliary cholangitis; LUSC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg11764359 chr7:65958608 NA -0.69 -10.39 -0.49 4.28e-22 Aortic root size; LUSC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11644478 chr21:40555479 PSMG1 0.88 15.87 0.66 1.19e-42 Cognitive function; LUSC cis rs317689 0.819 rs317660 chr12:69686203 G/A cg20891283 chr12:69753455 YEATS4 0.45 6.01 0.31 4.96e-9 Response to diuretic therapy; LUSC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs61931739 0.534 rs4086956 chr12:34105047 A/T cg06521331 chr12:34319734 NA -0.52 -8.62 -0.43 2.69e-16 Morning vs. evening chronotype; LUSC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.05 22.66 0.78 1.69e-69 Height; LUSC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg18350739 chr11:68623251 NA -0.35 -6.15 -0.32 2.18e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6541297 0.699 rs4846915 chr1:230296470 C/A cg20703242 chr1:230279135 GALNT2 0.5 5.72 0.3 2.33e-8 Coronary artery disease; LUSC cis rs6121246 0.529 rs6060171 chr20:30183269 C/T cg13852791 chr20:30311386 BCL2L1 0.71 8.05 0.4 1.49e-14 Mean corpuscular hemoglobin; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg25767906 chr1:53392781 SCP2 -0.52 -9.61 -0.47 1.79e-19 Monocyte count; LUSC trans rs61931739 0.500 rs34061369 chr12:34519283 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.25e-22 Morning vs. evening chronotype; LUSC cis rs7582180 0.629 rs6716636 chr2:100940067 C/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.6 -0.43 3.22e-16 Intelligence (multi-trait analysis); LUSC cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg18904891 chr8:8559673 CLDN23 0.59 8.15 0.41 7.49e-15 Obesity-related traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01669482 chr16:25043131 NA 0.47 6.58 0.34 1.84e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs12367572 0.965 rs11182706 chr12:45223339 T/C cg04608330 chr12:45269318 NELL2 -0.54 -8.37 -0.42 1.58e-15 Gut microbiome composition (summer); LUSC cis rs425277 1.000 rs262651 chr1:2091397 A/G cg24578937 chr1:2090814 PRKCZ 0.6 13.87 0.6 7.21e-35 Height; LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg08200582 chr11:442649 ANO9 -0.58 -6.56 -0.34 2e-10 Body mass index; LUSC cis rs9921338 0.961 rs4390613 chr16:11422836 T/C cg00044050 chr16:11439710 C16orf75 0.47 6.19 0.32 1.78e-9 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs11650494 0.710 rs8066722 chr17:47475007 A/G cg08112188 chr17:47440006 ZNF652 -0.88 -7.83 -0.39 6.49e-14 Prostate cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05364412 chr19:2136934 AP3D1 0.48 7.22 0.37 3.62e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1595825 0.786 rs73054839 chr2:198671665 C/A cg00982548 chr2:198649783 BOLL -0.6 -7.35 -0.37 1.55e-12 Ulcerative colitis; LUSC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg03806693 chr22:41940476 POLR3H 1.01 14.57 0.62 1.49e-37 Vitiligo; LUSC cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg21496419 chr19:44306685 LYPD5 0.33 6.51 0.34 2.76e-10 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs1814175 0.647 rs10839394 chr11:49844747 T/C cg15704280 chr7:45808275 SEPT13 -1.13 -24.46 -0.8 2.01e-76 Height; LUSC cis rs77106637 1.000 rs11600585 chr11:72727840 A/G cg03878208 chr11:72483293 STARD10 0.59 7.72 0.39 1.37e-13 Type 2 diabetes; LUSC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg20684491 chr1:25596433 NA 0.39 6.24 0.32 1.32e-9 Erythrocyte sedimentation rate; LUSC cis rs273573 0.925 rs163882 chr11:30947681 C/G cg06552810 chr11:31128660 NA 0.33 5.73 0.3 2.26e-8 Total body bone mineral density; LUSC cis rs72960926 0.744 rs72954354 chr6:74949552 C/G cg03266952 chr6:74778945 NA -0.77 -6.77 -0.35 5.96e-11 Metabolite levels (MHPG); LUSC cis rs936229 0.813 rs4886619 chr15:75106138 C/T cg14664628 chr15:75095509 CSK -1.02 -18.29 -0.71 3e-52 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7712401 0.601 rs246328 chr5:122287628 G/A cg19077854 chr5:122220652 SNX24 0.44 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs9393777 0.557 rs6933999 chr6:27074929 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.38 -6.14 -0.32 2.34e-9 Intelligence (multi-trait analysis); LUSC cis rs11229555 0.645 rs7946522 chr11:58197905 G/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg08219700 chr8:58056026 NA 0.47 6.24 0.32 1.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg20135002 chr11:47629003 NA 0.51 7.88 0.4 4.57e-14 Subjective well-being; LUSC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg05717871 chr11:638507 DRD4 -0.33 -5.84 -0.3 1.26e-8 Systemic lupus erythematosus; LUSC cis rs7937682 0.883 rs1789351 chr11:111456436 T/A cg22437258 chr11:111473054 SIK2 0.51 7.05 0.36 1e-11 Primary sclerosing cholangitis; LUSC cis rs6967385 0.934 rs17165850 chr7:12366064 G/C cg06484146 chr7:12443880 VWDE 0.42 6.15 0.32 2.26e-9 Response to taxane treatment (placlitaxel); LUSC cis rs9311676 0.618 rs11130639 chr3:58406004 G/T cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.1e-10 Systemic lupus erythematosus; LUSC cis rs2652834 0.851 rs4238372 chr15:63351488 G/A cg05507819 chr15:63340323 TPM1 0.69 8.66 0.43 2.05e-16 HDL cholesterol; LUSC cis rs950169 0.922 rs67804993 chr15:85104030 T/G cg17173187 chr15:85201210 NMB 0.37 6.53 0.34 2.41e-10 Schizophrenia; LUSC cis rs7923609 0.936 rs10761778 chr10:65273782 A/G cg01631684 chr10:65280961 REEP3 -0.42 -6.43 -0.33 4.38e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6842047 1.000 rs4862668 chr4:187136443 A/T cg09526685 chr4:187126073 CYP4V2 0.55 5.92 0.31 7.86e-9 Blood protein levels; LUSC cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg03146154 chr1:46216737 IPP 0.51 7.62 0.38 2.61e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs637571 0.544 rs617791 chr11:65702523 C/G cg26695010 chr11:65641043 EFEMP2 -0.45 -6.57 -0.34 1.91e-10 Eosinophil percentage of white cells; LUSC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11148252 0.669 rs61958050 chr13:52994427 A/C cg00495681 chr13:53174319 NA 0.52 7.58 0.38 3.43e-13 Lewy body disease; LUSC cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.27 0.45 2.43e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 8.02 0.4 1.86e-14 Bipolar disorder; LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg00149659 chr3:10157352 C3orf10 0.95 13.69 0.6 3.67e-34 Alzheimer's disease; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.12 0.41 9.16e-15 Prudent dietary pattern; LUSC cis rs2637266 1.000 rs1907305 chr10:78339512 C/G cg18941641 chr10:78392320 NA 0.36 6.51 0.34 2.69e-10 Pulmonary function; LUSC cis rs36051895 0.589 rs7874785 chr9:5196695 C/T cg02405213 chr9:5042618 JAK2 0.5 7.33 0.37 1.77e-12 Pediatric autoimmune diseases; LUSC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12756686 chr19:29218302 NA 0.67 9.56 0.46 2.68e-19 Methadone dose in opioid dependence; LUSC cis rs2191566 1.000 rs10418363 chr19:44525463 A/G cg03039196 chr19:44506973 ZNF230 0.36 5.83 0.3 1.29e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs12928939 0.815 rs34731378 chr16:71745748 C/T cg08717414 chr16:71523259 ZNF19 -0.42 -5.93 -0.31 7.68e-9 Post bronchodilator FEV1; LUSC cis rs2370759 1.000 rs76467481 chr10:32610740 T/G cg01819863 chr10:32635814 EPC1 1.05 12.98 0.58 1.79e-31 Sexual dysfunction (female); LUSC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.64 0.47 1.44e-19 Personality dimensions; LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg18099408 chr3:52552593 STAB1 -0.4 -6.85 -0.35 3.62e-11 Bipolar disorder; LUSC trans rs2048656 0.570 rs7814635 chr8:9646620 G/A cg08975724 chr8:8085496 FLJ10661 0.43 5.97 0.31 5.96e-9 Schizophrenia; LUSC trans rs12579753 0.917 rs7132732 chr12:82206053 C/G cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs7647973 0.848 rs4955411 chr3:49145304 A/G cg07636037 chr3:49044803 WDR6 0.96 11.89 0.55 1.93e-27 Menarche (age at onset); LUSC cis rs10883723 1.000 rs10883723 chr10:104225832 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -7.82 -0.39 6.78e-14 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4499344 0.730 rs28402742 chr19:33099734 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs7267979 0.816 rs443009 chr20:25499817 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -16.39 -0.67 1.03e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg06145435 chr7:1022769 CYP2W1 0.33 7.2 0.37 4.07e-12 Longevity;Endometriosis; LUSC cis rs7590368 1.000 rs17456225 chr2:10963238 C/G cg15705551 chr2:10952987 PDIA6 0.57 7.8 0.39 8.2e-14 Educational attainment (years of education); LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg26304593 chr6:42947056 PEX6 -0.53 -8.31 -0.41 2.44e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4363385 0.553 rs61813181 chr1:152942177 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.77 -0.3 1.77e-8 Inflammatory skin disease; LUSC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg13206674 chr6:150067644 NUP43 -0.59 -9.25 -0.45 2.79e-18 Lung cancer; LUSC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg14343924 chr8:8086146 FLJ10661 0.43 5.77 0.3 1.77e-8 Neuroticism; LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg05368731 chr17:41323189 NBR1 0.93 16.0 0.66 3.59e-43 Menopause (age at onset); LUSC cis rs7267979 1.000 rs3761117 chr20:25388070 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.12e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC trans rs634534 0.622 rs593525 chr11:65727799 T/C cg17712092 chr4:129076599 LARP1B 0.74 11.11 0.52 1.25e-24 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs4594175 0.926 rs7160948 chr14:51612537 T/A cg23942311 chr14:51606299 NA 0.3 5.79 0.3 1.6e-8 Cancer; LUSC cis rs6977660 1.000 rs6955510 chr7:19821333 G/C cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs644799 0.542 rs10831418 chr11:95468828 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.53 7.23 0.37 3.42e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg21951975 chr1:209979733 IRF6 0.42 6.97 0.36 1.67e-11 Monobrow; LUSC cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg23711669 chr6:146136114 FBXO30 -0.86 -15.9 -0.66 8.91e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs3126085 0.935 rs4845426 chr1:152195359 A/G cg03465714 chr1:152285911 FLG -0.41 -5.74 -0.3 2.09e-8 Atopic dermatitis; LUSC cis rs6542838 0.646 rs2008648 chr2:99408323 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.46 -6.37 -0.33 6.22e-10 Fear of minor pain; LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.38 6.04 0.31 4.07e-9 Electroencephalogram traits; LUSC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg15445000 chr17:37608096 MED1 0.4 6.77 0.35 5.76e-11 Glomerular filtration rate (creatinine); LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg11770404 chr20:60962048 RPS21 -0.36 -5.94 -0.31 7.02e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs6577655 0.561 rs6577654 chr8:135593610 G/A cg17885191 chr8:135476712 NA 0.59 7.4 0.38 1.09e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg12698349 chr2:225449008 CUL3 0.73 9.35 0.46 1.33e-18 IgE levels in asthmatics (D.p. specific); LUSC trans rs911555 0.504 rs4906340 chr14:104076645 G/A cg03785828 chr5:81573306 RPS23 0.43 6.99 0.36 1.53e-11 Intelligence (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg15362955 chr3:187463294 BCL6 -0.46 -6.98 -0.36 1.61e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs1350666 0.608 rs1017735 chr4:75253136 G/T cg12453539 chr20:6033866 LRRN4 -0.28 -5.99 -0.31 5.38e-9 Attention deficit hyperactivity disorder; LUSC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg20503657 chr10:835505 NA 1.19 15.42 0.64 7.03e-41 Eosinophil percentage of granulocytes; LUSC cis rs30380 0.632 rs26495 chr5:96137840 A/G cg16492584 chr5:96139282 ERAP1 -0.57 -7.71 -0.39 1.5e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs8017423 0.967 rs11623275 chr14:90721335 C/T cg14092571 chr14:90743983 NA -0.35 -5.83 -0.3 1.29e-8 Mortality in heart failure; LUSC cis rs9911578 1.000 rs2055779 chr17:57030561 A/G cg05425664 chr17:57184151 TRIM37 -0.57 -8.44 -0.42 1e-15 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03934478 chr11:495069 RNH1 0.85 9.73 0.47 7.4e-20 Body mass index; LUSC cis rs1577917 1.000 rs10455449 chr6:86592226 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.88 -0.44 4.24e-17 Response to antipsychotic treatment; LUSC cis rs506338 0.517 rs1207179 chr11:64450795 C/T cg19131476 chr11:64387923 NRXN2 0.36 7.9 0.4 4.15e-14 Body mass index;Urate levels; LUSC cis rs2742540 0.503 rs11042121 chr11:8932640 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.34 5.64 0.3 3.54e-8 Hematocrit; LUSC cis rs886126 0.650 rs4766566 chr12:111706877 C/T cg10833066 chr12:111807467 FAM109A 0.49 8.32 0.41 2.3e-15 Coronary heart disease; LUSC cis rs7666738 0.571 rs7683769 chr4:99091742 T/C cg05340658 chr4:99064831 C4orf37 0.57 9.22 0.45 3.46e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg15649852 chr7:65879115 NA -0.41 -5.78 -0.3 1.74e-8 Aortic root size; LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs6967385 0.538 rs10275154 chr7:12355002 T/C cg20607287 chr7:12443886 VWDE 0.5 7.52 0.38 5.06e-13 Response to taxane treatment (placlitaxel); LUSC cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg26384229 chr12:38710491 ALG10B 0.9 15.66 0.65 7.56e-42 Bladder cancer; LUSC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg03351412 chr1:154909251 PMVK 0.52 8.08 0.4 1.18e-14 Prostate cancer; LUSC cis rs7511006 1.000 rs7364173 chr22:50681029 C/T cg07895657 chr22:50616420 PANX2 0.34 5.91 0.31 8.52e-9 Obesity-related traits; LUSC cis rs4919087 1.000 rs10786330 chr10:99074959 C/A cg25902810 chr10:99078978 FRAT1 0.5 7.33 0.37 1.8e-12 Monocyte count; LUSC cis rs4285028 0.699 rs4676758 chr3:121583415 T/C cg11130432 chr3:121712080 ILDR1 0.63 9.66 0.47 1.28e-19 Multiple sclerosis; LUSC cis rs861020 0.606 rs695140 chr1:210005061 G/A cg05527609 chr1:210001259 C1orf107 0.67 9.63 0.47 1.5700000000000001e-19 Orofacial clefts; LUSC trans rs7829975 0.714 rs4841042 chr8:8664622 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.4 -0.33 5.19e-10 Mood instability; LUSC cis rs3125734 0.633 rs4561099 chr10:64041163 T/C cg19640130 chr10:64028056 RTKN2 -0.39 -6.84 -0.35 3.69e-11 Rheumatoid arthritis; LUSC cis rs4423214 1.000 rs12790558 chr11:71170905 T/C cg05163923 chr11:71159392 DHCR7 0.74 11.07 0.52 1.79e-24 Vitamin D levels; LUSC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs7000551 0.638 rs2469771 chr8:22376627 T/C cg12081754 chr8:22256438 SLC39A14 0.45 6.72 0.35 7.95e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs3733585 0.648 rs67820465 chr4:9975873 A/G cg26043149 chr18:55253948 FECH -0.46 -7.11 -0.36 7.3e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9658691 0.607 rs9658786 chr10:90776349 A/G cg03111039 chr10:90751583 FAS;ACTA2 0.58 5.92 0.31 8.13e-9 Mosquito bite size; LUSC cis rs9325144 0.560 rs1843910 chr12:38677408 T/C cg13010199 chr12:38710504 ALG10B -0.53 -8.07 -0.4 1.3e-14 Morning vs. evening chronotype; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg05165339 chr4:1420672 NA -0.29 -6.86 -0.35 3.31e-11 Longevity; LUSC cis rs12989701 1.000 rs6710467 chr2:127889932 C/T cg08168897 chr2:127865431 BIN1 0.62 8.1 0.41 1.01e-14 Alzheimer's disease (late onset); LUSC cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg05347473 chr6:146136440 FBXO30 0.57 9.99 0.48 9.56e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg23711669 chr6:146136114 FBXO30 0.8 14.44 0.62 4.65e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs7523050 0.643 rs7519293 chr1:109399543 A/G cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC trans rs8029989 1.000 rs8029989 chr15:38733847 A/G cg26796815 chr5:134094372 DDX46 -0.42 -6.02 -0.31 4.51e-9 Psychosis (atypical); LUSC cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg00071950 chr4:10020882 SLC2A9 0.58 9.7 0.47 9.12e-20 Bone mineral density; LUSC cis rs644799 0.509 rs561635 chr11:95634232 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.62 -8.35 -0.42 1.84e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg13047869 chr3:10149882 C3orf24 0.42 6.22 0.32 1.48e-9 Alzheimer's disease; LUSC cis rs1775715 0.707 rs2808087 chr10:32146444 C/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.9 0.4 3.96e-14 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14193481 chr6:105850839 PREP -0.43 -6.39 -0.33 5.42e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg13685833 chr1:53393034 SCP2 -0.37 -5.81 -0.3 1.43e-8 Monocyte count; LUSC cis rs9527 0.662 rs743575 chr10:104594906 T/G cg15744005 chr10:104629667 AS3MT -0.32 -6.3 -0.33 9.55e-10 Arsenic metabolism; LUSC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg09085632 chr11:111637200 PPP2R1B 1.03 15.27 0.64 2.63e-40 Primary sclerosing cholangitis; LUSC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6982240 0.514 rs11785274 chr8:142261541 G/A cg27411547 chr8:142287226 NA -0.47 -8.05 -0.4 1.45e-14 Tonsillectomy; LUSC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg19346786 chr7:2764209 NA -0.42 -7.36 -0.37 1.48e-12 Height; LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.17 0.41 6.44e-15 Prudent dietary pattern; LUSC cis rs72781680 0.898 rs12620558 chr2:23936022 G/A cg08917208 chr2:24149416 ATAD2B 1.0 10.16 0.49 2.55e-21 Lymphocyte counts; LUSC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg20503657 chr10:835505 NA 0.96 12.87 0.58 4.67e-31 Eosinophil percentage of granulocytes; LUSC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.09 0.32 3.1e-9 Personality dimensions; LUSC cis rs559928 0.606 rs12417635 chr11:63912728 C/T cg05555928 chr11:63887634 MACROD1 -0.48 -6.09 -0.32 3.08e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.82 -0.43 6.56e-17 Bipolar disorder; LUSC cis rs2153904 0.793 rs71633563 chr1:205735854 C/T cg23034840 chr1:205782522 SLC41A1 -0.65 -6.87 -0.35 3.22e-11 Prostate-specific antigen levels; LUSC cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 6.8 0.35 4.78e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10504229 0.679 rs16921676 chr8:58052386 G/T cg11062466 chr8:58055876 NA 0.53 6.97 0.36 1.72e-11 Developmental language disorder (linguistic errors); LUSC trans rs330048 0.545 rs11249913 chr8:9143521 G/T cg15556689 chr8:8085844 FLJ10661 -0.48 -6.94 -0.36 2.09e-11 Systemic lupus erythematosus; LUSC cis rs11690935 0.885 rs7602037 chr2:172817794 G/A cg13550731 chr2:172543902 DYNC1I2 -0.8 -12.92 -0.58 3.06e-31 Schizophrenia; LUSC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.69 0.54 1.11e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9549260 0.755 rs2701863 chr13:41170140 C/T cg21288729 chr13:41239152 FOXO1 0.59 8.84 0.44 5.79e-17 Red blood cell count; LUSC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg06637938 chr14:75390232 RPS6KL1 0.57 9.43 0.46 7.26e-19 Coronary artery disease; LUSC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg05802129 chr4:122689817 NA -0.37 -6.56 -0.34 2.06e-10 Type 2 diabetes; LUSC cis rs7582720 0.945 rs72934601 chr2:204031137 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.47 0.42 8.07e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg25251562 chr2:3704773 ALLC -0.52 -7.87 -0.4 4.86e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs847577 0.506 rs7808528 chr7:97721425 G/T cg21770322 chr7:97807741 LMTK2 0.56 9.85 0.47 2.85e-20 Breast cancer; LUSC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg12615879 chr12:58013172 SLC26A10 -0.27 -5.77 -0.3 1.78e-8 Multiple sclerosis; LUSC cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg08109568 chr15:31115862 NA -0.57 -7.53 -0.38 4.71e-13 Huntington's disease progression; LUSC trans rs629535 0.814 rs62513381 chr8:70110991 T/C cg21567404 chr3:27674614 NA -0.98 -15.88 -0.66 1.02e-42 Dupuytren's disease; LUSC cis rs7264396 0.690 rs2425171 chr20:34443173 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.53 -0.42 5.25e-16 Total cholesterol levels; LUSC cis rs7592578 0.771 rs10432434 chr2:191387079 T/G cg11845111 chr2:191398756 TMEM194B -0.9 -11.5 -0.53 5.27e-26 Diastolic blood pressure; LUSC trans rs6834483 1.000 rs1655083 chr4:35975257 A/G cg26559689 chr6:4905329 CDYL 0.69 5.95 0.31 6.76e-9 Obesity-related traits; LUSC cis rs6696846 0.791 rs10158848 chr1:205061192 C/T cg00857998 chr1:205179979 DSTYK 0.63 9.74 0.47 6.69e-20 Red blood cell count; LUSC cis rs6977660 0.891 rs10226962 chr7:19819464 T/C cg05791153 chr7:19748676 TWISTNB 0.55 6.11 0.32 2.81e-9 Thyroid stimulating hormone; LUSC cis rs7582180 0.606 rs11684004 chr2:100954783 C/T cg12002119 chr2:101014098 CHST10 0.35 5.66 0.3 3.22e-8 Intelligence (multi-trait analysis); LUSC cis rs5758511 0.679 rs55867855 chr22:42623258 G/A cg00645731 chr22:42541494 CYP2D7P1 0.57 10.0 0.48 8.88e-21 Birth weight; LUSC cis rs59698941 0.943 rs12515752 chr5:132312960 C/G cg14825688 chr5:132208181 LEAP2 -0.54 -5.77 -0.3 1.77e-8 Apolipoprotein A-IV levels; LUSC trans rs4083578 0.732 rs9572894 chr13:72702312 C/T cg14305763 chr2:28114016 BRE;RBKS;LOC100302650 0.43 6.08 0.32 3.2e-9 Cognitive performance; LUSC cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg03146154 chr1:46216737 IPP 0.51 7.5 0.38 5.68e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7605827 0.930 rs4668925 chr2:15703576 C/T cg19274914 chr2:15703543 NA 0.47 9.09 0.45 8.76e-18 Educational attainment (years of education); LUSC cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.31 6.75 0.35 6.39e-11 Coronary artery disease; LUSC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19346786 chr7:2764209 NA -0.43 -7.41 -0.38 1.07e-12 Height; LUSC cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.71 0.39 1.46e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs17767294 0.708 rs72848752 chr6:27878268 A/C cg08851530 chr6:28072375 NA 1.24 8.4 0.42 1.32e-15 Parkinson's disease; LUSC trans rs7838490 0.780 rs35642681 chr8:89685209 A/G cg24558378 chr1:183589673 NA 0.34 6.25 0.32 1.28e-9 Body mass index and cholesterol (psychopharmacological treatment); LUSC cis rs2979489 0.945 rs2979472 chr8:30291704 G/C cg26383811 chr8:30366931 RBPMS 0.48 7.36 0.37 1.46e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs7267979 1.000 rs2482930 chr20:25334115 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -17.87 -0.7 1.36e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg16049864 chr8:95962084 TP53INP1 -0.45 -7.52 -0.38 5.21e-13 Type 2 diabetes; LUSC cis rs6977940 0.643 rs73033417 chr7:2882855 C/G cg19731401 chr7:2775893 GNA12 0.7 7.68 0.39 1.78e-13 White matter integrity; LUSC cis rs9818941 1.000 rs4507209 chr3:157710946 T/A cg08654915 chr3:157813417 NA -0.25 -6.21 -0.32 1.57e-9 Height; LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg07507251 chr3:52567010 NT5DC2 0.34 6.67 0.34 1.06e-10 Bipolar disorder; LUSC trans rs2262909 0.962 rs11667209 chr19:22259467 A/G cg05197062 chr11:11642011 GALNTL4 0.56 7.88 0.4 4.75e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg08280861 chr8:58055591 NA 0.52 6.81 0.35 4.68e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg26441486 chr22:50317300 CRELD2 0.53 7.93 0.4 3.43e-14 Schizophrenia; LUSC cis rs9653442 0.866 rs12712065 chr2:100761105 C/G cg07810366 chr2:100720526 AFF3 -0.51 -8.81 -0.43 6.75e-17 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7189233 0.956 rs62048478 chr16:53429180 C/T cg09728985 chr16:53543985 NA -0.32 -5.73 -0.3 2.22e-8 Intelligence (multi-trait analysis); LUSC cis rs4654899 0.865 rs6426674 chr1:21483906 C/T cg01072550 chr1:21505969 NA -0.49 -7.36 -0.37 1.47e-12 Superior frontal gyrus grey matter volume; LUSC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.44 -0.38 8.81e-13 Height; LUSC cis rs2637266 1.000 rs34483246 chr10:78342790 G/A cg18941641 chr10:78392320 NA 0.4 7.41 0.38 1.04e-12 Pulmonary function; LUSC cis rs9914988 0.943 rs2043031 chr17:27085564 A/G cg09479241 chr17:27052676 TLCD1 0.43 5.82 0.3 1.35e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg25019033 chr10:957182 NA -0.51 -6.35 -0.33 7.22e-10 Eosinophil percentage of granulocytes; LUSC cis rs12249377 0.519 rs12259401 chr10:92594121 T/G cg14313238 chr10:92632228 RPP30 0.43 5.79 0.3 1.64e-8 White matter microstructure (global fractional anisotropy); LUSC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg24829409 chr8:58192753 C8orf71 -0.57 -7.24 -0.37 3.11e-12 Developmental language disorder (linguistic errors); LUSC cis rs10751667 0.857 rs6597952 chr11:991109 C/G cg06064525 chr11:970664 AP2A2 -0.36 -7.06 -0.36 9.65e-12 Alzheimer's disease (late onset); LUSC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2439831 0.867 rs2412778 chr15:43660982 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg18876405 chr7:65276391 NA -0.75 -13.52 -0.59 1.64e-33 Corneal structure; LUSC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg01579765 chr21:45077557 HSF2BP -0.54 -11.55 -0.53 3.31e-26 Mean corpuscular volume; LUSC cis rs7824557 0.592 rs920044 chr8:11224313 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.01 0.31 4.84e-9 Retinal vascular caliber; LUSC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg09904177 chr6:26538194 HMGN4 0.49 7.85 0.39 5.6e-14 Schizophrenia; LUSC cis rs2439831 0.681 rs1549525 chr15:43627855 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.44 0.65 5.93e-41 Lung cancer in ever smokers; LUSC cis rs11039100 0.681 rs11039120 chr11:5833096 A/G cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7772486 0.837 rs2474354 chr6:146323795 T/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.99 -0.36 1.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg23630131 chr7:65973040 NA -0.21 -6.01 -0.31 4.93e-9 Aortic root size; LUSC trans rs1005277 0.505 rs200935 chr10:38132810 T/A cg17830980 chr10:43048298 ZNF37B -0.43 -6.73 -0.35 7.2e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg15744005 chr10:104629667 AS3MT -0.35 -7.44 -0.38 8.33e-13 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs1728785 1.000 rs1728785 chr16:68591230 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.25 -0.41 3.73e-15 Ulcerative colitis; LUSC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.79 11.32 0.53 2.24e-25 Multiple sclerosis; LUSC cis rs7945705 0.875 rs10769955 chr11:8784647 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.57 11.25 0.52 4.21e-25 Hemoglobin concentration; LUSC cis rs9296092 0.538 rs62407566 chr6:33535786 C/T cg13560919 chr6:33536144 NA -0.88 -15.98 -0.66 4.2e-43 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg26380479 chr7:97908229 NA -0.26 -5.94 -0.31 7.3e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7833787 1.000 rs6993404 chr8:18705723 C/T cg17701159 chr8:18705777 PSD3 0.38 6.14 0.32 2.28e-9 Obesity-related traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13904199 chr9:86594091 HNRNPK 0.44 6.01 0.31 4.88e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg11494091 chr17:61959527 GH2 0.36 6.04 0.31 4.21e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg09085632 chr11:111637200 PPP2R1B -1.09 -17.41 -0.69 9.58e-49 Primary sclerosing cholangitis; LUSC cis rs7903847 0.646 rs10882924 chr10:99159304 T/A cg20016023 chr10:99160130 RRP12 -0.32 -7.86 -0.4 5.34e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg00343986 chr7:65444356 GUSB 0.48 7.13 0.36 6.14e-12 Aortic root size; LUSC cis rs4642101 0.561 rs7638333 chr3:12806142 T/C cg24848339 chr3:12840334 CAND2 0.32 6.35 0.33 6.95e-10 QRS complex (12-leadsum); LUSC cis rs858239 0.601 rs10278776 chr7:23169759 C/T cg23682824 chr7:23144976 KLHL7 0.41 5.94 0.31 7.13e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg18758796 chr5:131593413 PDLIM4 0.39 6.63 0.34 1.39e-10 Breast cancer; LUSC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg04362960 chr10:104952993 NT5C2 0.55 7.94 0.4 3.08e-14 Arsenic metabolism; LUSC trans rs2243480 1.000 rs313799 chr7:65494330 A/G cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.57e-15 Diabetic kidney disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26159030 chr19:36214806 MLL4 -0.73 -5.97 -0.31 6.06e-9 Cognitive performance; LUSC cis rs17540621 1.000 rs115394889 chr2:47250076 A/T cg23978866 chr2:47230407 TTC7A -0.88 -6.22 -0.32 1.45e-9 Response to statin therapy; LUSC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg09034736 chr1:150693464 HORMAD1 0.43 5.95 0.31 6.8e-9 Melanoma; LUSC cis rs34638657 0.656 rs2911429 chr16:82203443 T/C cg09439754 chr16:82129088 HSD17B2 -0.37 -5.97 -0.31 6.18e-9 Lung adenocarcinoma; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg03188948 chr7:1209495 NA 0.66 6.91 0.35 2.44e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg18402987 chr7:1209562 NA 0.71 7.85 0.39 5.89e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg09704166 chr2:114031854 PAX8;LOC440839 0.47 8.07 0.4 1.26e-14 Lymphocyte counts; LUSC cis rs4654899 1.000 rs6681064 chr1:21339644 A/G cg01072550 chr1:21505969 NA -0.53 -8.1 -0.41 1.02e-14 Superior frontal gyrus grey matter volume; LUSC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg23205692 chr1:25664452 TMEM50A 0.38 5.69 0.3 2.85e-8 Erythrocyte sedimentation rate; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg17330251 chr7:94953956 PON1 -0.37 -5.99 -0.31 5.57e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs600231 0.508 rs17146964 chr11:65249145 C/T cg17120908 chr11:65337727 SSSCA1 0.6 8.82 0.43 6.48e-17 Bone mineral density; LUSC cis rs722599 0.748 rs929579 chr14:75330697 C/T cg06637938 chr14:75390232 RPS6KL1 -0.43 -6.34 -0.33 7.64e-10 IgG glycosylation; LUSC cis rs4363385 0.818 rs2070964 chr1:153004213 C/T cg00922841 chr1:152955080 SPRR1A -0.42 -7.34 -0.37 1.64e-12 Inflammatory skin disease; LUSC cis rs6987853 0.563 rs2974301 chr8:42442238 A/G cg09913449 chr8:42400586 C8orf40 0.4 6.67 0.34 1.05e-10 Mean corpuscular hemoglobin concentration; LUSC cis rs344364 0.602 rs12719796 chr16:1921197 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.42 6.43 0.33 4.48e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg15145296 chr3:125709740 NA -0.55 -6.6 -0.34 1.66e-10 Blood pressure (smoking interaction); LUSC cis rs11674184 0.632 rs17529680 chr2:11727087 A/C cg07314298 chr2:11723111 GREB1 0.68 11.91 0.55 1.76e-27 Endometriosis; LUSC trans rs7829975 0.840 rs555617 chr8:8592845 C/G cg21775007 chr8:11205619 TDH -0.43 -6.01 -0.31 4.74e-9 Mood instability; LUSC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.44 -7.25 -0.37 2.98e-12 Hip circumference adjusted for BMI; LUSC cis rs4474465 0.920 rs7947852 chr11:78198030 T/C cg27205649 chr11:78285834 NARS2 -0.53 -6.19 -0.32 1.8e-9 Alzheimer's disease (survival time); LUSC cis rs7107174 1.000 rs2511171 chr11:77930935 G/A cg02023728 chr11:77925099 USP35 0.52 7.26 0.37 2.76e-12 Testicular germ cell tumor; LUSC cis rs10823500 0.604 rs10762345 chr10:71939374 A/G cg02100629 chr10:71892760 AIFM2 -0.39 -6.84 -0.35 3.85e-11 Blood protein levels; LUSC cis rs644799 0.735 rs10831432 chr11:95516040 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 14.15 0.61 6.21e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg16423285 chr20:60520624 NA -0.45 -5.71 -0.3 2.48e-8 Body mass index; LUSC cis rs372883 0.613 rs1153290 chr21:30687404 G/T cg24692254 chr21:30365293 RNF160 -0.69 -10.55 -0.5 1.23e-22 Pancreatic cancer; LUSC trans rs208520 0.661 rs851466 chr6:66840476 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.85 -0.68 1.53e-46 Exhaled nitric oxide output; LUSC cis rs832540 0.902 rs194059 chr5:56197416 G/A cg24531977 chr5:56204891 C5orf35 -0.6 -8.73 -0.43 1.22e-16 Coronary artery disease; LUSC trans rs1015213 0.609 rs117144627 chr8:52823157 A/C cg26618441 chr5:140213825 PCDHA6;PCDHA2;PCDHA1;PCDHA7;PCDHA5;PCDHA3;PCDHA4 -0.87 -6.09 -0.32 3.14e-9 Glaucoma (primary angle closure); LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg25894440 chr7:65020034 NA 0.37 5.72 0.3 2.37e-8 Calcium levels; LUSC cis rs1395 0.778 rs56364136 chr2:27451429 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.38 6.34 0.33 7.53e-10 Blood metabolite levels; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg12350185 chr22:32150051 DEPDC5 0.46 6.25 0.32 1.22e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9467773 1.000 rs10214634 chr6:26564582 T/A cg05738196 chr6:26577821 NA 0.82 15.85 0.66 1.46e-42 Intelligence (multi-trait analysis); LUSC cis rs2274459 1.000 rs729376 chr6:33704823 C/T cg06253072 chr6:33679850 C6orf125 0.52 5.98 0.31 5.85e-9 Obesity (extreme); LUSC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg19468946 chr17:37922297 IKZF3 -0.43 -6.8 -0.35 4.72e-11 Self-reported allergy; LUSC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg13393036 chr8:95962371 TP53INP1 -0.51 -11.17 -0.52 8.18e-25 Type 2 diabetes; LUSC cis rs11051970 0.611 rs56146365 chr12:32529634 A/G cg02745156 chr12:32552066 NA 0.39 6.95 0.36 1.94e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs7769051 1.000 rs12203977 chr6:133122760 A/G cg27275811 chr11:74457193 NA -0.64 -6.22 -0.32 1.51e-9 Type 2 diabetes nephropathy; LUSC cis rs6598955 0.671 rs17163749 chr1:26568165 A/G cg00852783 chr1:26633632 UBXN11 -0.51 -6.06 -0.31 3.72e-9 Obesity-related traits; LUSC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg14829155 chr15:31115871 NA 0.47 6.55 0.34 2.11e-10 Huntington's disease progression; LUSC trans rs11039798 1.000 rs7125559 chr11:48984207 C/G cg15704280 chr7:45808275 SEPT13 0.77 7.43 0.38 9.41e-13 Axial length; LUSC cis rs6725041 0.547 rs6753945 chr2:213204574 T/C cg16329650 chr2:213403929 ERBB4 -0.42 -6.67 -0.34 1.09e-10 QT interval (ambient particulate matter interaction); LUSC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg14668632 chr7:2872130 GNA12 -0.45 -6.61 -0.34 1.49e-10 Height; LUSC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg02772935 chr3:125709198 NA -0.48 -5.84 -0.3 1.23e-8 Blood pressure (smoking interaction); LUSC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs1372520 0.684 rs2619368 chr4:90729747 T/G cg15133208 chr4:90757351 SNCA -0.55 -8.63 -0.43 2.6e-16 Neuroticism; LUSC cis rs6430585 0.528 rs309158 chr2:136680534 A/G cg07169764 chr2:136633963 MCM6 1.04 16.65 0.67 9.21e-46 Corneal structure; LUSC cis rs3540 0.576 rs12907587 chr15:91045851 G/C cg10434728 chr15:90938212 IQGAP1 -0.45 -9.16 -0.45 5.38e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6426558 0.502 rs2813965 chr1:227445733 A/G cg10327440 chr1:227177885 CDC42BPA 0.56 7.54 0.38 4.46e-13 Neutrophil percentage of white cells; LUSC trans rs11098499 0.863 rs2170276 chr4:120485824 A/C cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.22e-13 Corneal astigmatism; LUSC cis rs10186029 0.509 rs6435755 chr2:213941131 C/T cg08319019 chr2:214017104 IKZF2 -0.41 -5.99 -0.31 5.48e-9 Systemic sclerosis; LUSC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg06637938 chr14:75390232 RPS6KL1 0.51 8.05 0.4 1.48e-14 Height; LUSC cis rs9660992 0.624 rs72745217 chr1:205261482 C/G cg21643547 chr1:205240462 TMCC2 -0.49 -9.3 -0.45 1.88e-18 Mean corpuscular volume;Mean platelet volume; LUSC trans rs6981523 0.553 rs11989369 chr8:11055385 A/G cg06636001 chr8:8085503 FLJ10661 0.47 6.01 0.31 4.84e-9 Neuroticism; LUSC cis rs17092148 0.945 rs17092080 chr20:33335657 A/G cg16810054 chr20:33298113 TP53INP2 -0.41 -6.42 -0.33 4.77e-10 Neuroticism; LUSC trans rs561341 0.739 rs6505267 chr17:30225950 A/C cg20587970 chr11:113659929 NA -0.75 -9.75 -0.47 6.09e-20 Hip circumference adjusted for BMI; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11172286 chr11:47600544 KBTBD4;NDUFS3 0.39 6.03 0.31 4.45e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7216064 1.000 rs7209675 chr17:65831258 A/T cg12091567 chr17:66097778 LOC651250 -0.73 -9.11 -0.45 7.71e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs12458462 0.892 rs2242174 chr18:77458037 T/C cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.48 -6.92 -0.35 2.28e-11 Monocyte count; LUSC cis rs2404602 0.552 rs11636612 chr15:76959530 C/T cg23625390 chr15:77176239 SCAPER -0.61 -8.63 -0.43 2.59e-16 Blood metabolite levels; LUSC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg06850241 chr22:41845214 NA 0.34 6.33 0.33 7.95e-10 Vitiligo; LUSC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg23711669 chr6:146136114 FBXO30 0.72 12.67 0.57 2.53e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg01579765 chr21:45077557 HSF2BP 0.48 9.69 0.47 9.92e-20 Mean corpuscular volume; LUSC cis rs10791323 0.575 rs4489760 chr11:133732265 A/T cg15485101 chr11:133734466 NA 0.37 7.06 0.36 9.8e-12 Childhood ear infection; LUSC trans rs2898290 0.622 rs1600250 chr8:11345425 A/C cg08975724 chr8:8085496 FLJ10661 -0.43 -6.35 -0.33 7.06e-10 Systolic blood pressure; LUSC cis rs7712401 0.755 rs10900759 chr5:122105080 T/A cg19077854 chr5:122220652 SNX24 0.31 6.78 0.35 5.48e-11 Mean platelet volume; LUSC cis rs806215 1.000 rs712703 chr7:127257498 C/T cg25922125 chr7:127225783 GCC1 -0.57 -7.29 -0.37 2.23e-12 Type 2 diabetes; LUSC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg04851639 chr8:1020857 NA 0.37 7.62 0.38 2.69e-13 Schizophrenia; LUSC cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg26384229 chr12:38710491 ALG10B 0.8 12.92 0.58 2.91e-31 Drug-induced liver injury (flucloxacillin); LUSC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.19 15.39 0.64 8.99e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10762132 chr2:113403533 SLC20A1 -0.43 -6.79 -0.35 5.19e-11 Electrocardiographic conduction measures; LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg26314531 chr2:26401878 FAM59B -0.73 -10.17 -0.49 2.34e-21 Gut microbiome composition (summer); LUSC cis rs6918586 0.658 rs198840 chr6:26112164 T/G cg17691542 chr6:26056736 HIST1H1C 0.4 5.99 0.31 5.45e-9 Schizophrenia; LUSC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.19 -0.49 2.08e-21 Bipolar disorder; LUSC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg04450456 chr4:17643702 FAM184B 0.38 6.46 0.33 3.77e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs6545883 0.931 rs778768 chr2:61790289 C/G cg15711740 chr2:61764176 XPO1 -0.5 -8.01 -0.4 1.93e-14 Tuberculosis; LUSC cis rs11645898 0.687 rs6499558 chr16:72102813 G/C cg14768367 chr16:72042858 DHODH -0.53 -6.27 -0.32 1.14e-9 Blood protein levels; LUSC cis rs7681440 0.715 rs17016305 chr4:90791381 A/G cg20003494 chr4:90757398 SNCA -0.37 -6.08 -0.32 3.35e-9 Dementia with Lewy bodies; LUSC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.76 -0.35 6.16e-11 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04230589 chr11:61735144 FTH1 -0.45 -6.85 -0.35 3.59e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg06815965 chr1:205818668 PM20D1 0.39 6.08 0.32 3.28e-9 Menarche (age at onset); LUSC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg13319975 chr6:146136371 FBXO30 0.51 7.62 0.39 2.57e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg11764359 chr7:65958608 NA -0.5 -6.26 -0.32 1.19e-9 Aortic root size; LUSC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11890956 chr21:40555474 PSMG1 1.04 20.81 0.75 2.95e-62 Cognitive function; LUSC cis rs9925964 0.591 rs11649653 chr16:30918487 C/G cg02466173 chr16:30829666 NA 0.37 6.79 0.35 5.07e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC trans rs11098499 0.691 rs10010355 chr4:120261043 A/G cg25214090 chr10:38739885 LOC399744 0.41 6.32 0.33 8.21e-10 Corneal astigmatism; LUSC trans rs587847 0.507 rs1379348 chr15:37809303 A/G cg18296784 chr11:116147929 NA -0.35 -6.64 -0.34 1.28e-10 Intraocular pressure; LUSC cis rs12950390 0.776 rs4793646 chr17:45853966 A/C cg06532163 chr17:45867833 NA 0.34 6.41 0.33 4.93e-10 IgG glycosylation; LUSC cis rs10992471 0.756 rs7027595 chr9:95131553 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.27 -0.41 3.2e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs40363 1.000 rs37768 chr16:3514777 T/C cg01073479 chr16:3509474 NAT15 0.4 5.76 0.3 1.88e-8 Tuberculosis; LUSC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg18196295 chr10:418757 DIP2C 0.49 8.12 0.41 8.96e-15 Psychosis in Alzheimer's disease; LUSC cis rs10823500 0.604 rs10740329 chr10:71941253 A/T cg02100629 chr10:71892760 AIFM2 0.38 6.44 0.33 4.17e-10 Blood protein levels; LUSC cis rs394563 0.591 rs237026 chr6:149720681 G/A cg07828024 chr6:149772892 ZC3H12D -0.34 -7.3 -0.37 2.16e-12 Dupuytren's disease; LUSC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg22496380 chr5:211416 CCDC127 -0.79 -9.1 -0.45 8.39e-18 Breast cancer; LUSC cis rs12220238 1.000 rs11000902 chr10:75920483 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.94 0.35 2.07e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs68092024 0.704 rs704576 chr3:99487154 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -6.14 -0.32 2.31e-9 Cleft lip with or without cleft palate; LUSC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.21 -0.52 5.73e-25 Mean corpuscular volume; LUSC cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg07606381 chr6:8435919 SLC35B3 0.72 12.12 0.55 2.79e-28 Motion sickness; LUSC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg03030879 chr14:75389066 RPS6KL1 -0.39 -7.58 -0.38 3.4e-13 Caffeine consumption; LUSC cis rs6939532 0.522 rs2073528 chr6:26375143 G/C cg09904177 chr6:26538194 HMGN4 -0.45 -6.42 -0.33 4.73e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7572733 0.555 rs2341778 chr2:198776546 G/A cg00792783 chr2:198669748 PLCL1 -0.45 -6.03 -0.31 4.26e-9 Dermatomyositis; LUSC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg19774624 chr17:42201019 HDAC5 -0.81 -13.53 -0.6 1.46e-33 Total body bone mineral density; LUSC cis rs6960043 0.846 rs7781710 chr7:15056045 T/A cg19272540 chr7:15055459 NA 0.33 8.04 0.4 1.57e-14 Type 2 diabetes; LUSC cis rs7084402 1.000 rs1346301 chr10:60267310 G/A cg07615347 chr10:60278583 BICC1 -0.36 -5.85 -0.3 1.18e-8 Refractive error; LUSC cis rs8051149 0.688 rs12444533 chr16:87869711 C/T cg01412419 chr16:87856264 NA 0.47 7.35 0.37 1.55e-12 Blood metabolite levels; LUSC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.82e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9303401 0.659 rs34556735 chr17:56694447 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.06 0.58 8.72e-32 Cognitive test performance; LUSC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs4919694 1.000 rs12254254 chr10:104765605 C/T cg04362960 chr10:104952993 NT5C2 1.17 13.76 0.6 2.02e-34 Arsenic metabolism; LUSC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg05234568 chr11:5960015 NA -0.56 -8.99 -0.44 1.82e-17 DNA methylation (variation); LUSC cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.39 0.33 5.53e-10 Rheumatoid arthritis; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg11965913 chr1:205819406 PM20D1 0.93 19.27 0.73 3.8e-56 Menarche (age at onset); LUSC cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg08975724 chr8:8085496 FLJ10661 -0.54 -7.67 -0.39 1.91e-13 Mood instability; LUSC cis rs7122539 0.646 rs569818 chr11:66570749 G/A cg24851651 chr11:66362959 CCS 0.55 9.98 0.48 1.07e-20 HIV-1 susceptibility; LUSC trans rs72674100 1.000 rs72882317 chr4:97991290 C/G cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg27572855 chr1:25598939 RHD -0.41 -7.29 -0.37 2.26e-12 Erythrocyte sedimentation rate; LUSC cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg02527881 chr3:46936655 PTH1R -0.66 -11.9 -0.55 1.84e-27 Birth weight; LUSC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg04369109 chr6:150039330 LATS1 -0.57 -8.34 -0.42 1.91e-15 Lung cancer; LUSC cis rs7192380 0.639 rs7186296 chr16:69808998 A/G cg00738113 chr16:70207722 CLEC18C 0.32 6.65 0.34 1.19e-10 Sjögren's syndrome; LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg16405210 chr4:1374714 KIAA1530 -0.83 -14.19 -0.61 4.23e-36 Longevity; LUSC cis rs10089 1.000 rs13355233 chr5:127425350 A/G cg19767477 chr5:127420684 SLC12A2 0.41 5.75 0.3 1.99e-8 Ileal carcinoids; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg16145915 chr7:1198662 ZFAND2A -0.47 -8.41 -0.42 1.17e-15 Longevity;Endometriosis; LUSC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg06112835 chr11:68658793 MRPL21 0.51 7.82 0.39 7.13e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2667011 0.759 rs2715931 chr2:160847638 A/C cg06573604 chr2:160760825 LY75 -0.49 -6.48 -0.33 3.29e-10 Bilirubin levels; LUSC cis rs807669 0.548 rs885979 chr22:19198375 T/C cg02655711 chr22:19163373 SLC25A1 0.66 12.03 0.55 6.18e-28 Metabolite levels; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg04267008 chr7:1944627 MAD1L1 -0.51 -7.63 -0.39 2.55e-13 Bipolar disorder and schizophrenia; LUSC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg12560992 chr17:57184187 TRIM37 -0.89 -17.46 -0.69 6.05e-49 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg08499158 chr17:42289980 UBTF -0.48 -8.26 -0.41 3.46e-15 Total body bone mineral density; LUSC cis rs6480314 0.831 rs6480318 chr10:69984105 T/C cg06988349 chr10:69991859 ATOH7 0.34 5.67 0.3 3.02e-8 Optic nerve measurement (disc area); LUSC cis rs6693567 0.565 rs35784258 chr1:150405882 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.09 0.36 8.16e-12 Migraine; LUSC cis rs9937943 0.667 rs35253850 chr16:74599103 T/C cg01733217 chr16:74700730 RFWD3 0.62 7.21 0.37 3.74e-12 Neutrophil percentage of white cells; LUSC cis rs4843185 0.576 rs381624 chr16:85728679 G/A cg26571870 chr16:85723150 GINS2 -0.35 -6.51 -0.34 2.68e-10 Platelet distribution width; LUSC cis rs826838 0.935 rs3886109 chr12:39189243 C/T cg13010199 chr12:38710504 ALG10B 0.69 11.81 0.54 3.94e-27 Heart rate; LUSC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg19346786 chr7:2764209 NA 0.36 6.3 0.33 9.64e-10 Height; LUSC cis rs4481887 0.676 rs7520659 chr1:248527586 C/A cg26353448 chr1:248524236 OR2T4 -0.31 -6.06 -0.31 3.63e-9 Common traits (Other); LUSC trans rs17261688 0.556 rs6843218 chr4:160997303 T/G cg06105778 chr5:176830667 F12 -0.53 -6.04 -0.31 4.21e-9 DNA methylation (variation); LUSC cis rs9318086 0.753 rs9553094 chr13:24474613 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.39 -5.96 -0.31 6.5e-9 Myopia (pathological); LUSC cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg26924012 chr15:45694286 SPATA5L1 1.12 19.82 0.74 2.37e-58 Homoarginine levels; LUSC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.8 -0.35 4.8e-11 Alzheimer's disease (late onset); LUSC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg17328964 chr8:145687451 CYHR1 0.54 8.81 0.43 6.9e-17 Age at first birth; LUSC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg26597838 chr10:835615 NA 0.95 12.63 0.57 3.77e-30 Eosinophil percentage of granulocytes; LUSC cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg04586622 chr2:25135609 ADCY3 0.32 6.18 0.32 1.92e-9 Body mass index; LUSC cis rs9473147 0.516 rs9367284 chr6:47516369 A/G cg20196966 chr6:47445060 CD2AP 0.41 5.8 0.3 1.57e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs8072100 0.811 rs1912483 chr17:45443494 A/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.33 -5.66 -0.3 3.21e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7599312 0.534 rs2371615 chr2:213405660 G/T cg20637307 chr2:213403960 ERBB4 0.45 7.66 0.39 2.09e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9796 0.870 rs3214068 chr15:41313064 C/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -7.0 -0.36 1.42e-11 Menopause (age at onset); LUSC trans rs853679 1.000 rs2799079 chr6:28235176 A/C cg01620082 chr3:125678407 NA -0.48 -6.13 -0.32 2.49e-9 Depression; LUSC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg18876405 chr7:65276391 NA -0.58 -9.41 -0.46 8.44e-19 Aortic root size; LUSC cis rs7615316 0.934 rs9816736 chr3:142172780 T/C cg16271453 chr3:142027066 XRN1 -0.41 -7.19 -0.37 4.26e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9325144 0.647 rs11169258 chr12:39113040 C/T cg26384229 chr12:38710491 ALG10B -0.6 -9.38 -0.46 1.01e-18 Morning vs. evening chronotype; LUSC cis rs7851660 0.809 rs3824495 chr9:100663700 A/C cg13688889 chr9:100608707 NA 0.54 8.43 0.42 1.05e-15 Strep throat; LUSC cis rs8014204 1.000 rs8014374 chr14:75322914 G/A cg06637938 chr14:75390232 RPS6KL1 -0.66 -10.95 -0.51 4.65e-24 Caffeine consumption; LUSC cis rs6456156 0.586 rs13195158 chr6:167481392 G/A cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs559928 0.606 rs12417635 chr11:63912728 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.19 0.37 4.21e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2288073 0.896 rs13404513 chr2:24410780 G/A cg06627628 chr2:24431161 ITSN2 -0.74 -10.35 -0.49 5.96e-22 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs2281558 0.876 rs12625157 chr20:25345549 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.63 9.64 0.47 1.44e-19 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg13628971 chr7:2884303 GNA12 0.44 6.4 0.33 5.34e-10 Height; LUSC cis rs7827545 0.961 rs4909482 chr8:135564786 G/T cg17885191 chr8:135476712 NA 0.56 8.32 0.41 2.34e-15 Hypertension (SNP x SNP interaction); LUSC cis rs864537 0.676 rs1773561 chr1:167421951 C/T cg22356347 chr1:167427500 CD247 -0.31 -7.08 -0.36 8.34e-12 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg15448220 chr1:150897856 SETDB1 0.42 6.09 0.32 3.05e-9 Melanoma; LUSC cis rs6541297 1.000 rs2144298 chr1:230280198 T/C cg05784532 chr1:230284198 GALNT2 0.54 8.05 0.4 1.46e-14 Coronary artery disease; LUSC cis rs9814567 0.727 rs7430034 chr3:134342127 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.63 -0.57 3.84e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs478304 0.934 rs570954 chr11:65498261 A/G cg08755490 chr11:65554678 OVOL1 0.4 5.72 0.3 2.37e-8 Acne (severe); LUSC cis rs2075371 0.611 rs35428392 chr7:134019645 G/A cg20476274 chr7:133979776 SLC35B4 0.79 13.11 0.58 5.59e-32 Mean platelet volume; LUSC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg24209194 chr3:40518798 ZNF619 -0.5 -7.07 -0.36 9.21e-12 Renal cell carcinoma; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg27094323 chr7:1216898 NA -0.35 -6.06 -0.31 3.58e-9 Longevity;Endometriosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16882097 chr18:21166899 NPC1 -0.42 -6.35 -0.33 6.9e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 14.7 0.63 4.49e-38 Platelet count; LUSC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 8.0 0.4 2.01e-14 Bipolar disorder; LUSC cis rs7851660 0.809 rs7048255 chr9:100665698 A/G cg13688889 chr9:100608707 NA -0.54 -8.43 -0.42 1.05e-15 Strep throat; LUSC cis rs722599 0.748 rs731952 chr14:75366447 A/G cg08847533 chr14:75593920 NEK9 0.47 6.75 0.35 6.5500000000000006e-11 IgG glycosylation; LUSC trans rs7939886 0.920 rs10431119 chr11:55977069 C/T cg03929089 chr4:120376271 NA 0.83 6.2 0.32 1.71e-9 Myopia (pathological); LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg21477170 chr4:3418713 RGS12 -0.34 -6.14 -0.32 2.33e-9 Major depressive disorder; LUSC trans rs61931739 0.500 rs34107854 chr12:34482333 C/A cg26384229 chr12:38710491 ALG10B 0.89 15.52 0.65 2.78e-41 Morning vs. evening chronotype; LUSC cis rs1997103 1.000 rs2331064 chr7:55408610 C/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2486288 0.656 rs11632724 chr15:45550791 G/A cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.8 -0.51 1.62e-23 Glomerular filtration rate; LUSC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg04398451 chr17:18023971 MYO15A -0.67 -11.53 -0.53 4.16e-26 Total body bone mineral density; LUSC cis rs9469578 0.579 rs59957785 chr6:33704601 C/T cg18708504 chr6:33715942 IP6K3 0.68 6.29 0.33 9.87e-10 Phosphorus levels; LUSC cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.88 -0.35 2.89e-11 Total body bone mineral density; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg27310827 chr1:1163671 SDF4 -0.41 -6.49 -0.33 3.05e-10 N-glycan levels; LUSC cis rs2692947 0.759 rs2692937 chr2:96751871 G/A cg22654517 chr2:96458247 NA 0.33 6.13 0.32 2.54e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg12219531 chr12:120966889 COQ5 0.58 7.61 0.38 2.78e-13 High light scatter reticulocyte count; LUSC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2742234 1.000 rs1864399 chr10:43610455 T/C cg15436174 chr10:43711423 RASGEF1A -0.37 -6.52 -0.34 2.6e-10 Hirschsprung disease; LUSC trans rs911555 0.755 rs8010247 chr14:103933556 A/G cg17675199 chr6:35436792 RPL10A -0.43 -6.31 -0.33 8.84e-10 Intelligence (multi-trait analysis); LUSC cis rs1878931 0.624 rs39728 chr16:3453076 A/T cg00484396 chr16:3507460 NAT15 -0.45 -6.81 -0.35 4.65e-11 Body mass index (adult); LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.29 5.72 0.3 2.33e-8 Lymphocyte counts; LUSC cis rs28647808 0.786 rs28590601 chr9:136256224 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs72781680 0.799 rs2712084 chr2:24003051 A/G cg08917208 chr2:24149416 ATAD2B 0.6 6.91 0.35 2.44e-11 Lymphocyte counts; LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 14.15 0.61 5.9e-36 Platelet count; LUSC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg08798685 chr6:27730294 NA -0.63 -5.74 -0.3 2.08e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg00071950 chr4:10020882 SLC2A9 -0.52 -8.01 -0.4 1.99e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg26384229 chr12:38710491 ALG10B 0.64 10.05 0.48 6.14e-21 Morning vs. evening chronotype; LUSC cis rs2439831 0.850 rs28564774 chr15:44125475 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.98 0.44 2e-17 Lung cancer in ever smokers; LUSC cis rs997295 0.713 rs12904982 chr15:68006279 T/C cg08079166 chr15:68083412 MAP2K5 -0.33 -6.51 -0.34 2.68e-10 Motion sickness; LUSC cis rs2073300 1.000 rs6137957 chr20:23437384 G/A cg12062639 chr20:23401060 NAPB 0.9 6.64 0.34 1.29e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs868036 0.681 rs1026737 chr15:68107072 A/C cg24579218 chr15:68104479 NA -0.39 -6.78 -0.35 5.39e-11 Restless legs syndrome; LUSC cis rs10771431 0.597 rs3759274 chr12:9353875 T/C cg08997352 chr12:9597637 DDX12 -0.71 -11.07 -0.52 1.83e-24 Breast size; LUSC cis rs12530845 1.000 rs12540325 chr7:135334111 T/C cg23117316 chr7:135346802 PL-5283 -0.58 -10.01 -0.48 8.1e-21 Red blood cell traits; LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.954 rs4345162 chr4:120312959 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs9916302 0.706 rs4516267 chr17:37471482 G/T cg07936489 chr17:37558343 FBXL20 0.78 9.96 0.48 1.27e-20 Glomerular filtration rate (creatinine); LUSC cis rs4654899 0.680 rs6704421 chr1:21220674 A/C cg01072550 chr1:21505969 NA 0.5 7.62 0.39 2.58e-13 Superior frontal gyrus grey matter volume; LUSC cis rs1355223 0.507 rs11032903 chr11:34876176 C/T cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.69 -0.34 9.51e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20667211 chr5:89770600 MBLAC2;POLR3G -0.43 -6.33 -0.33 7.81e-10 Electrocardiographic conduction measures; LUSC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg11766577 chr21:47581405 C21orf56 -0.4 -5.77 -0.3 1.86e-8 Testicular germ cell tumor; LUSC cis rs9486719 0.948 rs2472881 chr6:96862562 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg24642844 chr7:1081250 C7orf50 -0.8 -10.72 -0.51 3.14e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg23758822 chr17:41437982 NA 1.04 19.9 0.74 1.14e-58 Menopause (age at onset); LUSC trans rs9388451 0.839 rs4897155 chr6:126095144 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.34 -0.46 1.42e-18 Brugada syndrome; LUSC cis rs8064299 0.967 rs7420 chr17:72765215 A/G cg25054828 chr17:72772726 NAT9;TMEM104 -0.64 -11.14 -0.52 1.01e-24 Monocyte count; LUSC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg23158103 chr7:148848205 ZNF398 -0.44 -7.22 -0.37 3.6e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs782590 0.870 rs2586950 chr2:55868966 T/G cg18811423 chr2:55921094 PNPT1 0.79 13.13 0.58 4.87e-32 Metabolic syndrome; LUSC trans rs9393777 0.920 rs67859638 chr6:27357978 A/G cg01620082 chr3:125678407 NA -0.79 -6.86 -0.35 3.26e-11 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg09491104 chr22:46646882 C22orf40 -0.72 -9.22 -0.45 3.47e-18 LDL cholesterol;Cholesterol, total; LUSC cis rs78572108 0.858 rs12328618 chr2:42271261 G/A cg00607755 chr2:42274082 PKDCC 0.35 5.89 0.31 9.25e-9 Total body bone mineral density; LUSC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg20848291 chr7:100343083 ZAN -0.67 -9.26 -0.45 2.5e-18 Other erythrocyte phenotypes; LUSC cis rs7824557 0.707 rs3808519 chr8:11142970 C/G cg27411982 chr8:10470053 RP1L1 0.4 6.39 0.33 5.59e-10 Retinal vascular caliber; LUSC cis rs4343996 0.558 rs1915984 chr7:3409328 T/C cg21248987 chr7:3385318 SDK1 0.36 6.12 0.32 2.68e-9 Motion sickness; LUSC cis rs4766566 0.704 rs10774617 chr12:111755178 T/C cg10833066 chr12:111807467 FAM109A 0.54 9.35 0.46 1.34e-18 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC cis rs4974559 0.790 rs2293631 chr4:1315917 C/A cg02980000 chr4:1222292 CTBP1 0.84 9.45 0.46 6.36e-19 Systolic blood pressure; LUSC cis rs4474465 0.850 rs10899538 chr11:78237749 C/T cg27205649 chr11:78285834 NARS2 0.51 6.0 0.31 5.07e-9 Alzheimer's disease (survival time); LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg18404041 chr3:52824283 ITIH1 -0.53 -9.99 -0.48 9.79e-21 Bipolar disorder; LUSC trans rs3857536 0.813 rs9453639 chr6:66933538 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs7903847 0.667 rs10882931 chr10:99165794 C/A cg08345082 chr10:99160200 RRP12 -0.35 -7.22 -0.37 3.46e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7786877 0.521 rs4729607 chr7:100326744 T/A cg20848291 chr7:100343083 ZAN -0.62 -8.66 -0.43 2.1e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.51 0.56 1e-29 Motion sickness; LUSC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg24881330 chr22:46731750 TRMU 0.84 7.53 0.38 4.69e-13 LDL cholesterol;Cholesterol, total; LUSC trans rs941408 1.000 rs1640271 chr19:2799979 C/T cg22153745 chr1:153894579 GATAD2B -0.54 -8.7 -0.43 1.52e-16 Total cholesterol levels; LUSC trans rs561341 0.830 rs2301765 chr17:30202056 T/A cg27661571 chr11:113659931 NA 0.59 6.41 0.33 4.92e-10 Hip circumference adjusted for BMI; LUSC cis rs3790645 1.000 rs3127013 chr1:26891360 T/G cg17456097 chr1:26900765 RPS6KA1 0.41 5.93 0.31 7.6e-9 Glucose homeostasis traits; LUSC cis rs3126085 0.877 rs11204968 chr1:152250211 A/T cg26876637 chr1:152193138 HRNR 0.45 6.08 0.32 3.31e-9 Atopic dermatitis; LUSC cis rs174601 0.861 rs174550 chr11:61571478 T/C cg19610905 chr11:61596333 FADS2 -0.55 -8.26 -0.41 3.54e-15 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg13609457 chr4:120235615 NA 0.41 5.69 0.3 2.74e-8 Corneal astigmatism; LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg07507251 chr3:52567010 NT5DC2 0.34 6.55 0.34 2.15e-10 Bipolar disorder; LUSC cis rs11098499 0.954 rs11098524 chr4:120390032 A/G cg09307838 chr4:120376055 NA 0.69 9.32 0.45 1.65e-18 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24630566 chr15:41187168 VPS18 0.45 6.74 0.35 7.09e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2235649 0.753 rs4316755 chr16:1849916 T/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.1 -0.32 2.96e-9 Blood metabolite levels; LUSC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg08610935 chr16:1836813 NUBP2 -0.56 -8.94 -0.44 2.7e-17 Insulin-like growth factors; LUSC cis rs17270561 0.887 rs717551 chr6:25855624 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.2 0.49 1.89e-21 Iron status biomarkers; LUSC cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg25817165 chr18:72167213 CNDP2 -0.73 -9.93 -0.48 1.6e-20 Refractive error; LUSC trans rs2197308 0.765 rs11182900 chr12:37934009 C/T cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg16928487 chr17:17741425 SREBF1 0.45 8.78 0.43 8.74e-17 Total body bone mineral density; LUSC cis rs12791968 0.765 rs2279359 chr11:44999605 A/G cg11846598 chr11:44996168 LOC221122 0.61 8.77 0.43 9.5e-17 Inhibitory control; LUSC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg13206674 chr6:150067644 NUP43 0.61 9.77 0.47 5.32e-20 Lung cancer; LUSC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg13628971 chr7:2884303 GNA12 0.51 6.98 0.36 1.56e-11 Height; LUSC cis rs6469656 0.881 rs10096134 chr8:117663998 C/A cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg08558340 chr7:100472263 SRRT 0.46 5.95 0.31 6.59e-9 Resting heart rate; LUSC cis rs9486719 1.000 rs12530462 chr6:97053514 C/T cg06623918 chr6:96969491 KIAA0776 -0.83 -10.35 -0.49 5.8e-22 Migraine;Coronary artery disease; LUSC cis rs10504073 0.584 rs10957356 chr8:49980634 G/A cg00325661 chr8:49890786 NA 0.69 11.2 0.52 6.06e-25 Blood metabolite ratios; LUSC cis rs2050392 0.894 rs303430 chr10:30706235 C/A cg18806716 chr10:30721971 MAP3K8 -0.48 -7.9 -0.4 4.07e-14 Inflammatory bowel disease; LUSC cis rs12711979 0.513 rs7566217 chr2:3851381 A/C cg17052675 chr2:3827356 NA -0.33 -5.73 -0.3 2.2e-8 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs10992471 0.528 rs2296666 chr9:95274261 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.34 5.9 0.31 8.8e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg27535305 chr1:53392650 SCP2 -0.43 -8.48 -0.42 7.17e-16 Monocyte count; LUSC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg24675056 chr1:15929824 NA 0.44 7.65 0.39 2.11e-13 Systolic blood pressure; LUSC cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg04369109 chr6:150039330 LATS1 -0.55 -7.94 -0.4 3.13e-14 Lung cancer; LUSC cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg11266682 chr4:10021025 SLC2A9 0.56 10.49 0.5 1.91e-22 Bone mineral density; LUSC trans rs72792513 1.000 rs2879511 chr2:22920687 G/A cg05844895 chr16:88969569 CBFA2T3 0.5 6.2 0.32 1.69e-9 Hepatitis B; LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs1691799 0.899 rs1168357 chr12:66749879 T/C cg16791601 chr12:66731901 HELB -0.72 -12.56 -0.57 6.93e-30 White blood cell count (basophil); LUSC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg12564285 chr5:131593104 PDLIM4 -0.41 -7.54 -0.38 4.59e-13 Breast cancer; LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg07507251 chr3:52567010 NT5DC2 0.32 6.15 0.32 2.21e-9 Bipolar disorder; LUSC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg20848291 chr7:100343083 ZAN -0.51 -6.26 -0.32 1.17e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg26897989 chr16:1907736 C16orf73 -0.43 -6.73 -0.35 7.42e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9815354 1.000 rs9874513 chr3:41909508 G/A cg03022575 chr3:42003672 ULK4 0.61 6.69 0.34 9.3e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.92 -0.35 2.35e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs10203711 1.000 rs10187717 chr2:239558168 T/C cg14580085 chr2:239553406 NA 0.4 6.74 0.35 6.97e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg22105103 chr4:187893119 NA 0.69 12.71 0.57 1.82e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg00321850 chr1:175162397 KIAA0040 -0.49 -8.3 -0.41 2.63e-15 Diastolic blood pressure; LUSC cis rs72634258 0.945 rs36016881 chr1:8051241 A/G cg26816564 chr1:7831052 VAMP3 0.48 6.21 0.32 1.55e-9 Inflammatory bowel disease; LUSC cis rs7927592 0.913 rs2282563 chr11:68333200 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.73 -0.3 2.28e-8 Total body bone mineral density; LUSC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg24768116 chr2:27665128 KRTCAP3 0.35 7.01 0.36 1.34e-11 Total body bone mineral density; LUSC cis rs4654899 0.796 rs77366434 chr1:21520069 C/T cg01072550 chr1:21505969 NA -0.5 -7.45 -0.38 8e-13 Superior frontal gyrus grey matter volume; LUSC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.99 0.4 2.22e-14 Bipolar disorder; LUSC cis rs11190604 1.000 rs9419897 chr10:102246125 T/C cg07080220 chr10:102295463 HIF1AN 0.65 8.83 0.44 6.01e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg22029157 chr1:209979665 IRF6 0.69 9.9 0.48 1.96e-20 Cleft lip with or without cleft palate; LUSC cis rs7937682 0.924 rs501089 chr11:111502479 G/T cg22437258 chr11:111473054 SIK2 -0.45 -5.7 -0.3 2.58e-8 Primary sclerosing cholangitis; LUSC cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.88 -0.4 4.58e-14 Crohn's disease; LUSC cis rs617219 0.889 rs1622238 chr5:78437340 A/G cg24856658 chr5:78533917 JMY -0.3 -5.66 -0.3 3.29e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs11158026 0.757 rs8019220 chr14:55453469 C/T cg04306507 chr14:55594613 LGALS3 0.37 7.4 0.38 1.14e-12 Parkinson's disease; LUSC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg16339924 chr4:17578868 LAP3 0.6 9.43 0.46 7.3e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg22834771 chr12:69754056 YEATS4 -0.49 -7.26 -0.37 2.81e-12 Blood protein levels; LUSC cis rs34779708 0.741 rs34397613 chr10:35550313 A/G cg03585969 chr10:35415529 CREM 0.52 7.18 0.37 4.44e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4356932 1.000 rs10003382 chr4:76955473 C/T cg00809888 chr4:76862425 NAAA 0.35 5.85 0.3 1.2e-8 Blood protein levels; LUSC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs9549367 0.713 rs556990 chr13:113845059 T/C cg00898013 chr13:113819073 PROZ 0.54 8.02 0.4 1.76e-14 Platelet distribution width; LUSC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg06363034 chr20:62225388 GMEB2 -0.46 -7.68 -0.39 1.79e-13 Glioblastoma; LUSC cis rs9653442 0.712 rs7582731 chr2:100686486 T/C cg22139774 chr2:100720529 AFF3 -0.49 -8.35 -0.42 1.8e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4631830 0.863 rs6481329 chr10:51529746 G/A cg10326726 chr10:51549505 MSMB -0.37 -6.31 -0.33 8.67e-10 Prostate-specific antigen levels; LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg01879757 chr17:41196368 BRCA1 -0.46 -7.0 -0.36 1.42e-11 Menopause (age at onset); LUSC trans rs7615952 0.605 rs11708269 chr3:125332150 C/T cg07211511 chr3:129823064 LOC729375 -0.75 -7.17 -0.37 4.92e-12 Blood pressure (smoking interaction); LUSC cis rs13385 0.769 rs11538394 chr5:139574050 G/A cg26211634 chr5:139558579 C5orf32 0.44 6.31 0.33 8.82e-10 Atrial fibrillation; LUSC trans rs35110281 0.715 rs2838320 chr21:44995037 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.87 0.51 9.28e-24 Mean corpuscular volume; LUSC cis rs614226 1.000 rs614226 chr12:120974510 C/T cg27489772 chr12:121021490 NA -0.55 -7.29 -0.37 2.21e-12 Type 1 diabetes nephropathy; LUSC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg20821713 chr7:1055600 C7orf50 -0.46 -6.09 -0.32 3.13e-9 Bronchopulmonary dysplasia; LUSC cis rs7647973 0.710 rs11130207 chr3:49611666 T/G cg07636037 chr3:49044803 WDR6 0.55 5.69 0.3 2.82e-8 Menarche (age at onset); LUSC cis rs5770917 1.000 rs115743514 chr22:51011933 T/C cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.65 -5.7 -0.3 2.66e-8 Narcolepsy; LUSC cis rs6977660 0.714 rs10244210 chr7:19823972 T/C cg05791153 chr7:19748676 TWISTNB 0.67 6.93 0.35 2.24e-11 Thyroid stimulating hormone; LUSC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg27535305 chr1:53392650 SCP2 0.32 5.9 0.31 8.7e-9 Monocyte count; LUSC trans rs1486139 1.000 rs7779479 chr7:46267620 A/G cg17534202 chr9:96721102 NA -0.35 -6.15 -0.32 2.26e-9 Select biomarker traits; LUSC cis rs75920871 0.512 rs6589583 chr11:116863766 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.52 -0.34 2.59e-10 Subjective well-being; LUSC cis rs713477 1.000 rs12888361 chr14:55906187 A/G cg13175173 chr14:55914753 NA -0.32 -6.77 -0.35 5.7e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs1801251 1.000 rs283484 chr2:233646505 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.43 0.33 4.36e-10 Coronary artery disease; LUSC cis rs7246657 0.882 rs59224125 chr19:37963205 T/C cg23950597 chr19:37808831 NA -0.63 -7.5 -0.38 5.65e-13 Coronary artery calcification; LUSC cis rs259282 0.605 rs8100423 chr19:33109003 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.64 9.66 0.47 1.3e-19 Schizophrenia; LUSC cis rs8051149 0.793 rs34831152 chr16:87870607 A/G cg01412419 chr16:87856264 NA 0.44 6.48 0.33 3.2e-10 Blood metabolite levels; LUSC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg17376030 chr22:41985996 PMM1 -0.48 -5.99 -0.31 5.37e-9 Vitiligo; LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg13047869 chr3:10149882 C3orf24 0.54 7.03 0.36 1.18e-11 Alzheimer's disease; LUSC cis rs9800506 0.584 rs12203632 chr6:35518738 T/C cg03566752 chr6:35512600 NA 0.35 7.87 0.4 4.87e-14 Neutrophil percentage of granulocytes; LUSC cis rs10754283 0.967 rs10801763 chr1:90120822 C/T cg21401794 chr1:90099060 LRRC8C 0.61 8.78 0.43 8.66e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2625529 0.652 rs8028115 chr15:72339503 C/T cg16672083 chr15:72433130 SENP8 0.48 8.05 0.4 1.44e-14 Red blood cell count; LUSC cis rs10203711 1.000 rs10191070 chr2:239565413 A/G cg14580085 chr2:239553406 NA 0.41 6.97 0.36 1.71e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1784581 0.588 rs7451121 chr6:162412344 A/G cg17173639 chr6:162384350 PARK2 0.57 9.94 0.48 1.44e-20 Itch intensity from mosquito bite; LUSC cis rs644799 0.710 rs56384142 chr11:95502075 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.12 0.58 5.41e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs61931739 0.929 rs1844524 chr12:34094709 A/T cg26384229 chr12:38710491 ALG10B -0.58 -9.3 -0.45 1.89e-18 Morning vs. evening chronotype; LUSC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg09640425 chr7:158790006 NA -0.41 -6.47 -0.33 3.53e-10 Facial morphology (factor 20); LUSC cis rs4919694 0.611 rs2271750 chr10:105174869 A/G cg04362960 chr10:104952993 NT5C2 -0.95 -10.57 -0.5 9.97e-23 Arsenic metabolism; LUSC cis rs2836633 0.929 rs2836602 chr21:40039169 A/T cg12884169 chr21:40033163 ERG -0.59 -11.77 -0.54 5.32e-27 Coronary artery disease; LUSC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg08798685 chr6:27730294 NA -0.63 -6.01 -0.31 4.99e-9 Breast cancer; LUSC cis rs11645898 0.935 rs8047881 chr16:72193906 A/G cg14768367 chr16:72042858 DHODH -0.6 -6.74 -0.35 6.93e-11 Blood protein levels; LUSC trans rs7939886 0.920 rs10792448 chr11:55804542 C/G cg03929089 chr4:120376271 NA 0.74 6.28 0.32 1.07e-9 Myopia (pathological); LUSC cis rs981844 1.000 rs2606328 chr4:154653864 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.59 0.34 1.69e-10 Response to statins (LDL cholesterol change); LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg00166722 chr3:10149974 C3orf24 -0.49 -6.44 -0.33 4.13e-10 Alzheimer's disease; LUSC cis rs6598955 0.671 rs12085416 chr1:26627835 T/C cg00852783 chr1:26633632 UBXN11 -0.5 -5.86 -0.31 1.13e-8 Obesity-related traits; LUSC cis rs9527 0.590 rs1046411 chr10:104837816 G/A cg04362960 chr10:104952993 NT5C2 0.62 9.48 0.46 4.79e-19 Arsenic metabolism; LUSC cis rs9399135 0.933 rs4559100 chr6:135324085 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.63e-18 Red blood cell count; LUSC cis rs6138458 0.620 rs914314 chr20:24897355 C/T cg22963164 chr20:24940490 CST7 0.58 5.73 0.3 2.19e-8 Blood protein levels; LUSC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg15744005 chr10:104629667 AS3MT 0.31 6.51 0.34 2.84e-10 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs5769765 0.704 rs138837 chr22:50180714 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.67 -9.09 -0.45 9.1e-18 Schizophrenia; LUSC cis rs11105298 0.786 rs10858867 chr12:89851166 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.22 -0.37 3.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06096994 chr13:41635664 WBP4 -0.55 -6.49 -0.33 3.11e-10 Bipolar disorder and schizophrenia; LUSC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg17211192 chr8:82754475 SNX16 0.58 8.21 0.41 4.83e-15 Diastolic blood pressure; LUSC cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg10820045 chr2:198174542 NA -0.33 -6.02 -0.31 4.49e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC trans rs4596713 0.568 rs7850547 chr9:71747208 G/A cg25283916 chr1:242222868 NA -0.3 -6.25 -0.32 1.28e-9 Headache; LUSC cis rs6754311 0.593 rs10195620 chr2:136495619 A/T cg07169764 chr2:136633963 MCM6 -0.59 -7.78 -0.39 9.31e-14 Mosquito bite size; LUSC cis rs68092024 0.704 rs704576 chr3:99487154 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 6.34 0.33 7.66e-10 Cleft lip with or without cleft palate; LUSC cis rs7909074 0.966 rs4245614 chr10:45397007 C/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.43 -0.42 1.06e-15 Mean corpuscular volume; LUSC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg09323728 chr8:95962352 TP53INP1 -0.39 -7.73 -0.39 1.25e-13 Type 2 diabetes; LUSC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg01017244 chr2:74357527 NA 0.69 13.25 0.59 1.7e-32 Gestational age at birth (maternal effect); LUSC cis rs4363385 0.693 rs4845331 chr1:152982623 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.33e-13 Inflammatory skin disease; LUSC cis rs34638657 0.833 rs7200628 chr16:82200747 C/T cg09439754 chr16:82129088 HSD17B2 -0.4 -6.44 -0.33 4.26e-10 Lung adenocarcinoma; LUSC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg03709012 chr19:19516395 GATAD2A -0.76 -11.99 -0.55 8.98e-28 Tonsillectomy; LUSC cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.19 0.37 4.31e-12 Motion sickness; LUSC trans rs6502050 0.740 rs4789748 chr17:80093061 A/C cg07393940 chr7:158741817 NA 0.38 7.06 0.36 9.57e-12 Life satisfaction; LUSC trans rs61931739 0.500 rs56404399 chr12:34543101 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC trans rs17685 0.671 rs10274404 chr7:75706634 G/A cg19862616 chr7:65841803 NCRNA00174 1.13 19.47 0.73 5.91e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg07741184 chr6:167504864 NA -0.36 -6.59 -0.34 1.73e-10 Crohn's disease; LUSC cis rs7267979 1.000 rs6037086 chr20:25306338 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.73 -0.7 4.95e-50 Liver enzyme levels (alkaline phosphatase); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11487532 chr11:44586968 CD82 -0.47 -5.99 -0.31 5.32e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.39 0.46 9.85e-19 Prudent dietary pattern; LUSC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg12963246 chr6:28129442 ZNF389 0.52 7.47 0.38 6.9e-13 Parkinson's disease; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg23131131 chr22:24373011 LOC391322 -0.49 -7.1 -0.36 7.67e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.97 20.82 0.75 2.64e-62 Subjective well-being; LUSC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg03388025 chr16:89894329 SPIRE2 0.34 6.94 0.35 2.1e-11 Vitiligo; LUSC cis rs9644630 0.965 rs10105097 chr8:19364883 A/C cg01280390 chr8:19363452 CSGALNACT1 -0.37 -7.09 -0.36 7.91e-12 Oropharynx cancer; LUSC cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg27129171 chr3:47204927 SETD2 -0.7 -11.85 -0.54 2.84e-27 Colorectal cancer; LUSC cis rs8072100 0.846 rs4264433 chr17:45737275 A/T cg08085267 chr17:45401833 C17orf57 0.62 10.31 0.49 8.19e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7582720 0.945 rs72936875 chr2:203791912 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs778371 0.915 rs748002 chr2:233757679 G/A cg08000102 chr2:233561755 GIGYF2 -0.72 -10.3 -0.49 8.93e-22 Schizophrenia; LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg00149659 chr3:10157352 C3orf10 0.89 12.11 0.55 3.04e-28 Alzheimer's disease; LUSC trans rs1908814 0.516 rs10113145 chr8:11793295 A/G cg08975724 chr8:8085496 FLJ10661 0.48 6.96 0.36 1.79e-11 Neuroticism; LUSC cis rs6741892 0.590 rs12469534 chr2:38912029 G/A cg23643435 chr2:38893251 GALM -0.71 -5.69 -0.3 2.8e-8 5-HTT brain serotonin transporter levels; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg06873352 chr17:61820015 STRADA 0.7 12.65 0.57 3.11e-30 Prudent dietary pattern; LUSC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg11062466 chr8:58055876 NA 0.71 8.53 0.42 5.07e-16 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.84 -0.3 1.22e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg22823121 chr1:150693482 HORMAD1 -0.5 -7.37 -0.37 1.38e-12 Melanoma; LUSC cis rs34734847 0.933 rs998727 chr12:121149064 T/G cg27246729 chr12:121163418 ACADS 0.46 7.3 0.37 2.14e-12 Mean corpuscular volume; LUSC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg23625390 chr15:77176239 SCAPER 0.5 7.68 0.39 1.77e-13 Blood metabolite levels; LUSC cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg08999081 chr20:33150536 PIGU 0.37 6.87 0.35 3.09e-11 Height; LUSC cis rs9815354 0.638 rs73069277 chr3:41967521 C/T cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg22496339 chr2:162101262 NA -0.4 -5.64 -0.3 3.55e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs9427116 0.967 rs7547072 chr1:154639255 A/G cg17218026 chr1:154582156 ADAR -0.36 -6.3 -0.33 9.13e-10 Blood protein levels; LUSC cis rs9929218 1.000 rs2113200 chr16:68814948 A/T cg02972257 chr16:68554789 NA 0.44 6.01 0.31 4.89e-9 Colorectal cancer; LUSC cis rs12286929 0.839 rs11215375 chr11:115014002 C/T cg04055981 chr11:115044050 NA 0.36 6.16 0.32 2.07e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg06784218 chr1:46089804 CCDC17 0.54 10.59 0.5 8.43e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs80282103 0.867 rs7075830 chr10:1091650 G/C cg23359895 chr10:1095482 IDI1 0.63 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18099408 chr3:52552593 STAB1 0.42 7.57 0.38 3.78e-13 Bipolar disorder; LUSC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7647973 1.000 rs13088309 chr3:49368317 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.43 6.49 0.33 3.02e-10 Menarche (age at onset); LUSC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs9811920 0.965 rs9289981 chr3:99868104 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.34 6.49 0.33 3.03e-10 Axial length; LUSC trans rs3942852 0.550 rs1113480 chr11:48058313 G/T cg03929089 chr4:120376271 NA -0.53 -6.46 -0.33 3.67e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs8060686 0.641 rs76053508 chr16:68243054 A/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.39 -0.33 5.59e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs13401104 0.686 rs1530954 chr2:237110960 C/G cg19324714 chr2:237145437 ASB18 0.43 5.79 0.3 1.6e-8 Educational attainment; LUSC cis rs7824557 0.628 rs7005469 chr8:11194457 G/A cg21293242 chr8:11204541 TDH 0.31 5.89 0.31 9.28e-9 Retinal vascular caliber; LUSC cis rs6674176 0.542 rs803675 chr1:44353237 G/A cg12908607 chr1:44402522 ARTN -0.4 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1371867 0.817 rs1788179 chr8:101333345 A/G cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs6546537 0.503 rs13433043 chr2:69906658 T/C cg10773587 chr2:69614142 GFPT1 -0.46 -6.7 -0.34 8.78e-11 Serum thyroid-stimulating hormone levels; LUSC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg18681998 chr4:17616180 MED28 0.86 16.52 0.67 3.2e-45 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg03709012 chr19:19516395 GATAD2A -0.76 -11.97 -0.55 9.96e-28 Tonsillectomy; LUSC cis rs9837602 1.000 rs17379739 chr3:99724792 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 6.14 0.32 2.35e-9 Breast cancer; LUSC cis rs1395 0.778 rs1439767 chr2:27389634 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.49 7.2 0.37 4.12e-12 Blood metabolite levels; LUSC cis rs4595586 0.545 rs4768526 chr12:39402898 A/G cg09788416 chr12:39539408 NA 0.37 5.7 0.3 2.6e-8 Morning vs. evening chronotype; LUSC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg00750074 chr16:89608354 SPG7 -0.45 -6.7 -0.34 9.08e-11 Multiple myeloma (IgH translocation); LUSC cis rs7808935 0.914 rs757136 chr7:27988939 C/T cg22168087 chr7:27702803 HIBADH -0.61 -7.36 -0.37 1.43e-12 Prostate cancer; LUSC cis rs71403859 0.730 rs12447672 chr16:71715131 G/A cg08717414 chr16:71523259 ZNF19 -0.67 -7.44 -0.38 8.49e-13 Post bronchodilator FEV1; LUSC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.26 0.32 1.19e-9 Tonsillectomy; LUSC cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.53e-9 Breast cancer; LUSC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs4930103 0.935 rs2839698 chr11:2018853 G/A cg06197492 chr11:2016605 H19 0.42 6.94 0.35 2.08e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs76878669 0.561 rs7117630 chr11:66154777 C/T cg18002602 chr11:66138449 SLC29A2 -0.48 -8.56 -0.42 4.11e-16 Educational attainment (years of education); LUSC cis rs2115630 0.905 rs6496401 chr15:85297793 A/T cg09876464 chr15:85330779 ZNF592 0.37 6.86 0.35 3.41e-11 P wave terminal force; LUSC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.13 0.58 4.71e-32 Hip circumference adjusted for BMI; LUSC trans rs12310956 0.510 rs10772109 chr12:33839548 A/C cg13010199 chr12:38710504 ALG10B -0.47 -7.23 -0.37 3.38e-12 Morning vs. evening chronotype; LUSC trans rs61931739 0.635 rs1486884 chr12:33908876 A/T cg13010199 chr12:38710504 ALG10B -0.39 -6.02 -0.31 4.61e-9 Morning vs. evening chronotype; LUSC cis rs4654899 0.897 rs611658 chr1:21089133 T/G cg01072550 chr1:21505969 NA -0.45 -6.7 -0.34 9.04e-11 Superior frontal gyrus grey matter volume; LUSC cis rs10089 0.953 rs6595807 chr5:127531603 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 10.89 0.51 7.95e-24 Ileal carcinoids; LUSC trans rs7647973 0.710 rs12637313 chr3:49645458 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 7e-13 Menarche (age at onset); LUSC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg14895029 chr7:2775587 GNA12 -0.38 -6.08 -0.32 3.31e-9 Height; LUSC cis rs10072221 0.836 rs7706926 chr5:75707153 C/G cg03132911 chr5:75698732 IQGAP2 -0.34 -5.68 -0.3 2.86e-8 Mean platelet volume; LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg14092988 chr3:52407081 DNAH1 0.33 6.41 0.33 4.93e-10 Bipolar disorder; LUSC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs7819412 0.715 rs35223712 chr8:11043926 C/T cg21775007 chr8:11205619 TDH -0.5 -7.01 -0.36 1.3e-11 Triglycerides; LUSC cis rs9473147 1.000 rs9473147 chr6:47609592 A/G cg12968598 chr6:47444699 CD2AP 0.4 5.87 0.31 1.05e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs6424115 0.594 rs10799802 chr1:24009544 C/T cg10978503 chr1:24200527 CNR2 0.31 6.45 0.33 4.03e-10 Immature fraction of reticulocytes; LUSC cis rs3820068 0.705 rs2042369 chr1:15843244 A/G cg17385448 chr1:15911702 AGMAT -0.37 -5.88 -0.31 9.92e-9 Systolic blood pressure; LUSC cis rs1878931 0.513 rs35160989 chr16:3405506 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.86 16.21 0.66 5.07e-44 Body mass index (adult); LUSC cis rs11785400 1.000 rs4327844 chr8:143733540 C/T cg24634471 chr8:143751801 JRK -0.56 -8.75 -0.43 1.04e-16 Schizophrenia; LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.03 -0.31 4.28e-9 Platelet count; LUSC cis rs694739 0.726 rs17857342 chr11:64138905 T/G cg26898376 chr11:64110657 CCDC88B 0.33 6.17 0.32 1.92e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg18876405 chr7:65276391 NA 0.56 8.82 0.43 6.35e-17 Aortic root size; LUSC cis rs4919087 0.810 rs10736115 chr10:99031685 A/G cg25902810 chr10:99078978 FRAT1 0.47 6.85 0.35 3.66e-11 Monocyte count; LUSC cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs3859192 0.599 rs2227321 chr17:38171294 G/C cg17467752 chr17:38218738 THRA -0.51 -7.2 -0.37 4.05e-12 White blood cell count; LUSC cis rs6424115 0.729 rs561733 chr1:24049595 T/G cg10978503 chr1:24200527 CNR2 0.45 10.08 0.48 4.74e-21 Immature fraction of reticulocytes; LUSC cis rs9611565 0.765 rs727563 chr22:41867377 C/T cg03806693 chr22:41940476 POLR3H 0.84 12.05 0.55 5.34e-28 Vitiligo; LUSC cis rs7523050 0.908 rs17621621 chr1:109398917 G/T cg08274380 chr1:109419600 GPSM2 0.92 9.73 0.47 7.24e-20 Fat distribution (HIV); LUSC cis rs2625529 0.586 rs59975112 chr15:72423710 G/T cg16672083 chr15:72433130 SENP8 0.49 8.16 0.41 6.81e-15 Red blood cell count; LUSC cis rs10992471 0.756 rs10115222 chr9:95128149 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.46 7.77 0.39 9.66e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg26769984 chr7:1090371 C7orf50 0.7 9.79 0.47 4.77e-20 Bronchopulmonary dysplasia; LUSC cis rs7312933 0.702 rs10785333 chr12:42586470 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.52 -7.1 -0.36 7.64e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs62103177 0.525 rs9949598 chr18:77753037 G/A cg20368463 chr18:77673604 PQLC1 -0.62 -6.77 -0.35 5.69e-11 Opioid sensitivity; LUSC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs10266483 0.739 rs2692104 chr7:63760955 G/C cg24201672 chr7:64023550 ZNF680 -0.5 -6.6 -0.34 1.61e-10 Response to statin therapy; LUSC cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg18099408 chr3:52552593 STAB1 0.35 5.71 0.3 2.46e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg25809561 chr17:30822961 MYO1D 0.51 9.19 0.45 4.45e-18 Schizophrenia; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg20887711 chr4:1340912 KIAA1530 0.45 7.09 0.36 8.08e-12 Obesity-related traits; LUSC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg05872129 chr22:39784769 NA -0.58 -10.59 -0.5 8.65e-23 Intelligence (multi-trait analysis); LUSC cis rs3740540 0.507 rs897293 chr10:126290050 T/G cg04949429 chr10:126290192 LHPP 0.36 7.71 0.39 1.44e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs9807841 0.670 rs2010492 chr19:10803395 A/G cg09936142 chr19:10668400 KRI1 -0.42 -6.6 -0.34 1.62e-10 Inflammatory skin disease; LUSC cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.99 0.55 8.58e-28 Chronic sinus infection; LUSC cis rs9399135 0.935 rs6908681 chr6:135337733 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.07 0.44 1.01e-17 Red blood cell count; LUSC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg23093090 chr10:104574429 C10orf26 -0.37 -6.94 -0.35 2.06e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7312933 0.618 rs6582394 chr12:42686189 A/G cg01256987 chr12:42539512 GXYLT1 -0.4 -7.3 -0.37 2.05e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6785206 0.614 rs2712430 chr3:128337438 A/C cg16766828 chr3:128327626 NA -0.7 -7.66 -0.39 2.01e-13 Lymphocyte percentage of white cells; LUSC cis rs2580764 0.540 rs2920893 chr2:55270629 C/T cg20993754 chr2:55226987 RTN4 -0.36 -5.97 -0.31 5.96e-9 Mean platelet volume; LUSC cis rs738322 1.000 rs4379 chr22:38569171 T/C cg17652424 chr22:38574118 PLA2G6 -0.3 -6.63 -0.34 1.39e-10 Cutaneous nevi; LUSC cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -8.21 -0.41 4.93e-15 Schizophrenia; LUSC cis rs694739 0.894 rs887314 chr11:64053157 T/G cg02228329 chr11:64053129 BAD;GPR137 0.53 7.51 0.38 5.29e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs9747201 1.000 rs56051385 chr17:80126712 T/C cg07393940 chr7:158741817 NA -0.54 -8.66 -0.43 2.04e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg05347473 chr6:146136440 FBXO30 0.45 7.84 0.39 6.31e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.21 0.37 3.75e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg11494091 chr17:61959527 GH2 0.65 13.74 0.6 2.37e-34 Prudent dietary pattern; LUSC cis rs9300255 0.602 rs1716160 chr12:123700225 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg27532560 chr4:187881888 NA -0.37 -5.85 -0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg10523679 chr1:76189770 ACADM 0.9 12.96 0.58 2.23e-31 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs853679 0.607 rs13199772 chr6:27834085 A/G cg01620082 chr3:125678407 NA -0.82 -7.32 -0.37 1.84e-12 Depression; LUSC cis rs6088580 0.524 rs6088575 chr20:33273403 C/T cg24642439 chr20:33292090 TP53INP2 0.49 7.35 0.37 1.51e-12 Glomerular filtration rate (creatinine); LUSC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg22834771 chr12:69754056 YEATS4 0.43 6.12 0.32 2.56e-9 Blood protein levels; LUSC cis rs10189230 0.967 rs12479119 chr2:222354213 C/T cg14652038 chr2:222343519 EPHA4 0.32 5.72 0.3 2.35e-8 Urate levels in lean individuals; LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.44 7.48 0.38 6.8e-13 Electroencephalogram traits; LUSC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg20203395 chr5:56204925 C5orf35 0.75 10.35 0.49 6.01e-22 Initial pursuit acceleration; LUSC cis rs17030434 0.953 rs11099906 chr4:154691690 A/T cg14289246 chr4:154710475 SFRP2 -0.49 -6.53 -0.34 2.46e-10 Electrocardiographic conduction measures; LUSC cis rs1451375 0.652 rs7803440 chr7:50625632 C/T cg18232548 chr7:50535776 DDC 0.48 6.53 0.34 2.49e-10 Malaria; LUSC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.46e-11 Tonsillectomy; LUSC cis rs12681288 0.723 rs35425201 chr8:971062 C/T cg04851639 chr8:1020857 NA -0.4 -8.28 -0.41 3.09e-15 Schizophrenia; LUSC cis rs400736 0.860 rs2294890 chr1:8086527 T/G cg25007680 chr1:8021821 PARK7 0.55 8.43 0.42 1.06e-15 Response to antidepressants and depression; LUSC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg24881330 chr22:46731750 TRMU 0.83 7.24 0.37 3.03e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs7940866 0.845 rs1991899 chr11:130801649 C/T cg12179176 chr11:130786555 SNX19 -0.62 -9.76 -0.47 5.96e-20 Schizophrenia; LUSC trans rs7681440 0.904 rs6816736 chr4:90765746 G/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg13319975 chr6:146136371 FBXO30 0.49 7.42 0.38 9.79e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs11148252 0.514 rs2296347 chr13:52728423 A/C cg00495681 chr13:53174319 NA -0.4 -5.87 -0.31 1.03e-8 Lewy body disease; LUSC cis rs2295359 0.892 rs17375018 chr1:67655147 A/G cg03340356 chr1:67600835 NA -0.41 -6.59 -0.34 1.69e-10 Psoriasis; LUSC trans rs11098499 0.754 rs28643450 chr4:120245242 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.56 0.34 2.08e-10 Corneal astigmatism; LUSC cis rs9326248 0.539 rs10892065 chr11:116897024 T/C cg01368799 chr11:117014884 PAFAH1B2 0.61 9.46 0.46 5.81e-19 Blood protein levels; LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg19318889 chr4:1322082 MAEA -0.71 -12.13 -0.55 2.74e-28 Obesity-related traits; LUSC cis rs2769264 0.546 rs12071705 chr1:151430504 G/C cg18801370 chr1:151430492 POGZ 0.86 9.48 0.46 5.02e-19 Blood trace element (Cu levels); LUSC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.08e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg12751644 chr20:60527061 NA -0.33 -5.89 -0.31 9.2e-9 Body mass index; LUSC cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg20503657 chr10:835505 NA 0.87 11.62 0.54 1.95e-26 Eosinophil percentage of granulocytes; LUSC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg09877947 chr5:131593287 PDLIM4 -0.42 -6.43 -0.33 4.5e-10 Breast cancer; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg08219700 chr8:58056026 NA 0.69 7.93 0.4 3.34e-14 Developmental language disorder (linguistic errors); LUSC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg11752832 chr7:134001865 SLC35B4 0.56 8.61 0.43 2.92e-16 Mean platelet volume; LUSC trans rs73019876 0.869 rs2158107 chr19:22151345 T/G cg16204205 chr18:19753432 GATA6 0.32 6.04 0.31 4.16e-9 Testicular germ cell tumor; LUSC cis rs6681460 0.866 rs1856318 chr1:67024215 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.65 0.43 2.19e-16 Presence of antiphospholipid antibodies; LUSC cis rs76878669 0.561 rs4244813 chr11:66129488 G/C cg18002602 chr11:66138449 SLC29A2 0.45 8.12 0.41 8.95e-15 Educational attainment (years of education); LUSC cis rs11190604 1.000 rs3750719 chr10:102248950 C/G cg07080220 chr10:102295463 HIF1AN 0.65 8.4 0.42 1.29e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9814567 1.000 rs6790466 chr3:134197740 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.03e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg12463550 chr7:65579703 CRCP 0.55 8.17 0.41 6.35e-15 Aortic root size; LUSC cis rs1997103 1.000 rs12532070 chr7:55407698 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs41563 0.607 rs6955349 chr7:104601236 G/A cg00790307 chr17:17684042 SMCR5;RAI1 -0.29 -5.98 -0.31 5.71e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs7726839 0.561 rs3915384 chr5:573395 G/T cg25482853 chr8:67687455 SGK3 0.98 14.62 0.62 9.44e-38 Obesity-related traits; LUSC cis rs6964587 0.755 rs13229505 chr7:91444679 G/T cg17063962 chr7:91808500 NA 0.56 8.51 0.42 5.83e-16 Breast cancer; LUSC trans rs853679 0.546 rs200952 chr6:27836976 C/T cg01620082 chr3:125678407 NA -0.74 -7.22 -0.37 3.52e-12 Depression; LUSC cis rs6696846 0.740 rs11240369 chr1:205115099 G/A cg00857998 chr1:205179979 DSTYK 0.66 10.44 0.5 2.8e-22 Red blood cell count; LUSC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg12560992 chr17:57184187 TRIM37 0.83 15.25 0.64 3.29e-40 Intelligence (multi-trait analysis); LUSC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg18252515 chr7:66147081 NA -1.24 -13.96 -0.61 3.38e-35 Diabetic kidney disease; LUSC cis rs12291225 0.877 rs2303974 chr11:14264979 G/T cg19336497 chr11:14380999 RRAS2 -0.5 -9.65 -0.47 1.31e-19 Sense of smell; LUSC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.04 0.55 5.73e-28 Hip circumference adjusted for BMI; LUSC cis rs2404602 0.684 rs11072602 chr15:76873467 T/C cg23625390 chr15:77176239 SCAPER -0.66 -10.05 -0.48 6.35e-21 Blood metabolite levels; LUSC cis rs2346177 0.781 rs1447563 chr2:46637364 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.5 -7.86 -0.39 5.47e-14 HDL cholesterol; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg09033563 chr22:24373618 LOC391322 -0.49 -6.82 -0.35 4.29e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7246967 0.673 rs73022763 chr19:22894216 C/T cg23217946 chr19:22817039 ZNF492 0.41 5.7 0.3 2.67e-8 Bronchopulmonary dysplasia; LUSC cis rs2806561 0.780 rs6650086 chr1:23338384 T/C cg19743168 chr1:23544995 NA -0.38 -7.94 -0.4 3.14e-14 Height; LUSC cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.12 0.32 2.62e-9 Rheumatoid arthritis; LUSC cis rs7833986 0.534 rs2667972 chr8:56906661 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.68 10.98 0.51 3.87e-24 Height; LUSC cis rs2629540 0.889 rs7090422 chr10:126439361 T/A cg08799069 chr10:126477246 METTL10 -0.7 -10.47 -0.5 2.27e-22 Cocaine dependence; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg27284194 chr4:1044797 NA -0.37 -6.34 -0.33 7.36e-10 Obesity-related traits; LUSC cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg23711669 chr6:146136114 FBXO30 0.86 15.51 0.65 2.94e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg16680214 chr1:154839983 KCNN3 -0.52 -9.96 -0.48 1.29e-20 Prostate cancer; LUSC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg22857025 chr5:266934 NA 1.11 16.27 0.66 3.07e-44 Breast cancer; LUSC cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.42 -7.76 -0.39 1.05e-13 Monocyte percentage of white cells; LUSC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg11247378 chr22:39784982 NA -0.6 -10.6 -0.5 7.82e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs7618501 0.633 rs9861216 chr3:50059339 A/G cg21659725 chr3:3221576 CRBN -0.62 -10.18 -0.49 2.2e-21 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2808591 chr1:231523421 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs9921222 0.521 rs757460 chr16:367174 G/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.42 6.58 0.34 1.85e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs7903847 0.620 rs2297988 chr10:99118382 A/G cg20016023 chr10:99160130 RRP12 -0.33 -7.87 -0.4 5.03e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg18306943 chr3:40428807 ENTPD3 -0.38 -6.05 -0.31 3.97e-9 Renal cell carcinoma; LUSC cis rs11997175 0.558 rs9792124 chr8:33797689 A/C ch.8.33884649F chr8:33765107 NA 0.42 6.16 0.32 2.07e-9 Body mass index; LUSC cis rs17685 0.523 rs10246583 chr7:75746667 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.78 -0.39 9.37e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg08807101 chr21:30365312 RNF160 0.79 14.96 0.63 4.4e-39 Dental caries; LUSC cis rs9443645 0.527 rs10943588 chr6:79510994 A/C cg05283184 chr6:79620031 NA -0.46 -8.45 -0.42 9.37e-16 Intelligence (multi-trait analysis); LUSC trans rs17685 0.672 rs55807301 chr7:75807401 C/A cg19862616 chr7:65841803 NCRNA00174 1.09 18.29 0.71 2.82e-52 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs12579753 1.000 rs10862372 chr12:82249804 C/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.88 -0.31 9.99e-9 Resting heart rate; LUSC trans rs6502050 0.835 rs6502070 chr17:80112634 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs9311676 0.656 rs62258120 chr3:58391128 G/A cg26110898 chr3:58419937 PDHB 0.4 6.46 0.33 3.74e-10 Systemic lupus erythematosus; LUSC cis rs3015497 0.624 rs3015488 chr14:51135309 A/G cg26011998 chr14:51135199 SAV1 -0.46 -5.76 -0.3 1.9e-8 Mean platelet volume; LUSC trans rs2229238 0.911 rs10047079 chr1:154468135 T/C cg25273160 chr11:56955011 LRRC55 0.31 6.05 0.31 3.81e-9 Coronary heart disease; LUSC cis rs4595586 0.505 rs76485055 chr12:39358294 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC trans rs6502050 0.835 rs56232956 chr17:80078929 C/T cg07393940 chr7:158741817 NA -0.37 -6.59 -0.34 1.72e-10 Life satisfaction; LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg15790184 chr11:494944 RNH1 0.58 6.26 0.32 1.18e-9 Body mass index; LUSC cis rs7267979 0.816 rs1044573 chr20:25206654 A/G cg08601574 chr20:25228251 PYGB 0.49 8.0 0.4 2.08e-14 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg23711669 chr6:146136114 FBXO30 0.72 12.65 0.57 3.14e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs1997103 1.000 rs9642580 chr7:55400359 G/A cg17469321 chr7:55412551 NA 0.66 10.47 0.5 2.18e-22 QRS interval (sulfonylurea treatment interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13926468 chr13:115080241 ZNF828 0.45 6.3 0.33 9.33e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg18132916 chr6:79620363 NA -0.37 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.71 -0.34 8.1e-11 Lung cancer; LUSC cis rs921968 0.643 rs833083 chr2:219336959 A/T cg02176678 chr2:219576539 TTLL4 -0.6 -10.77 -0.51 2.07e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs7191439 0.589 rs11076699 chr16:88756812 A/C cg27087555 chr16:88793112 FAM38A 0.83 6.84 0.35 3.85e-11 Plateletcrit; LUSC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.06 16.32 0.67 1.88e-44 Age-related macular degeneration (geographic atrophy); LUSC cis rs71403859 0.730 rs12927768 chr16:71645263 G/A cg08717414 chr16:71523259 ZNF19 -0.69 -7.72 -0.39 1.4e-13 Post bronchodilator FEV1; LUSC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg18252515 chr7:66147081 NA -1.22 -14.04 -0.61 1.61e-35 Diabetic kidney disease; LUSC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs713587 0.967 rs713586 chr2:25158008 A/G cg04586622 chr2:25135609 ADCY3 0.34 7.03 0.36 1.15e-11 Body mass index in non-asthmatics; LUSC cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg13535736 chr9:111863775 C9orf5 -0.41 -6.56 -0.34 2.03e-10 Menarche (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21407906 chr20:61427925 C20orf20 -0.45 -6.09 -0.32 3.12e-9 Bipolar disorder and schizophrenia; LUSC cis rs432925 0.600 rs214247 chr16:349221 A/G cg08823186 chr16:347294 AXIN1 0.35 6.15 0.32 2.19e-9 Morning vs. evening chronotype; LUSC cis rs9549260 0.712 rs1334241 chr13:41223110 C/T cg21288729 chr13:41239152 FOXO1 0.58 6.41 0.33 5.02e-10 Red blood cell count; LUSC cis rs6714710 0.603 rs11692010 chr2:98397301 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.41 0.42 1.17e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs2980439 0.818 rs2945249 chr8:8094726 G/A cg21775007 chr8:11205619 TDH 0.45 6.28 0.32 1.08e-9 Neuroticism; LUSC cis rs11785400 0.793 rs4301430 chr8:143737416 A/G cg10596483 chr8:143751796 JRK 0.53 7.54 0.38 4.49e-13 Schizophrenia; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg07553338 chr16:71598813 NA 0.43 6.52 0.34 2.52e-10 Schizophrenia; LUSC cis rs6088813 1.000 rs1540927 chr20:33931344 A/G cg14752227 chr20:34000481 UQCC -0.36 -5.65 -0.3 3.4e-8 Height; LUSC cis rs2040771 0.804 rs7286849 chr22:19223579 C/A cg02655711 chr22:19163373 SLC25A1 0.47 8.42 0.42 1.13e-15 Metabolite levels (small molecules and protein measures); LUSC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg26314531 chr2:26401878 FAM59B -0.7 -9.6 -0.46 2.02e-19 Gut microbiome composition (summer); LUSC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg06850241 chr22:41845214 NA 0.31 5.72 0.3 2.39e-8 Vitiligo; LUSC trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg15704280 chr7:45808275 SEPT13 -0.86 -11.92 -0.55 1.52e-27 Coronary artery disease; LUSC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg02773041 chr1:40204384 PPIE 0.5 7.36 0.37 1.4e-12 Blood protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08949621 chr15:42265044 EHD4 0.4 6.03 0.31 4.31e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs8073060 0.586 rs225256 chr17:33955756 C/T cg19694781 chr19:47549865 TMEM160 -1.13 -18.17 -0.71 8.74e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg22875332 chr1:76189707 ACADM 0.77 10.28 0.49 9.81e-22 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6600671 0.934 rs67718113 chr1:121238910 C/T cg00646200 chr1:148855367 NA -0.5 -7.87 -0.4 4.94e-14 Hip geometry; LUSC cis rs1784581 0.894 rs1784594 chr6:162382734 A/G cg17173639 chr6:162384350 PARK2 -0.8 -15.14 -0.64 8.97e-40 Itch intensity from mosquito bite; LUSC cis rs8017423 0.967 rs4900030 chr14:90689813 T/A cg04374321 chr14:90722782 PSMC1 0.71 11.26 0.52 3.66e-25 Mortality in heart failure; LUSC cis rs1113500 0.933 rs11185250 chr1:108616417 A/G cg06207961 chr1:108661230 NA 0.42 7.8 0.39 8.21e-14 Growth-regulated protein alpha levels; LUSC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.0 -0.31 5.24e-9 Huntington's disease progression; LUSC cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg14458575 chr2:238380390 NA 0.78 13.75 0.6 2.07e-34 Prostate cancer; LUSC trans rs629535 0.773 rs72654090 chr8:70118666 G/A cg21567404 chr3:27674614 NA -0.97 -15.8 -0.65 2.14e-42 Dupuytren's disease; LUSC cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg06671706 chr8:8559999 CLDN23 0.48 6.44 0.33 4.23e-10 Obesity-related traits; LUSC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg03806693 chr22:41940476 POLR3H -0.96 -13.04 -0.58 1.08e-31 Vitiligo; LUSC cis rs12594515 1.000 rs12592190 chr15:45994028 G/A cg19682013 chr15:45996608 NA 0.38 5.68 0.3 2.87e-8 Waist circumference;Weight; LUSC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg06363034 chr20:62225388 GMEB2 -0.46 -7.7 -0.39 1.53e-13 Glioblastoma; LUSC cis rs73200209 0.744 rs7974638 chr12:116462700 C/G cg01776926 chr12:116560359 MED13L -0.48 -5.87 -0.31 1.03e-8 Total body bone mineral density; LUSC cis rs8038465 1.000 rs67257650 chr15:73979507 C/T cg15420318 chr15:73925796 NPTN 0.4 6.26 0.32 1.21e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg15448220 chr1:150897856 SETDB1 0.43 6.3 0.33 9.35e-10 Melanoma; LUSC cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.07 0.48 5.08e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9677476 0.909 rs10181602 chr2:232121642 G/C cg07929768 chr2:232055508 NA 0.33 6.1 0.32 2.92e-9 Food antigen IgG levels; LUSC cis rs61931739 0.500 rs11053251 chr12:34520743 A/G cg06521331 chr12:34319734 NA -0.41 -6.8 -0.35 4.96e-11 Morning vs. evening chronotype; LUSC cis rs3820068 0.705 rs72645808 chr1:15870118 G/C cg17385448 chr1:15911702 AGMAT 0.4 5.87 0.31 1.04e-8 Systolic blood pressure; LUSC cis rs9902453 1.000 rs4533340 chr17:28277951 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.93 0.44 2.95e-17 Coffee consumption (cups per day); LUSC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC trans rs1814175 0.817 rs10839318 chr11:49657511 G/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.19 -0.8 2.06e-75 Height; LUSC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg11279151 chr3:101281821 RG9MTD1 -0.39 -5.68 -0.3 2.9e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9311676 0.632 rs34086582 chr3:58419944 C/T cg26110898 chr3:58419937 PDHB 0.4 6.4 0.33 5.22e-10 Systemic lupus erythematosus; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 13.72 0.6 2.65e-34 Platelet count; LUSC cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg05868516 chr6:26286170 HIST1H4H 0.37 6.05 0.31 3.99e-9 Educational attainment; LUSC cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.12 0.36 6.53e-12 Colorectal cancer; LUSC cis rs9658691 0.607 rs9658757 chr10:90769455 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -6.15 -0.32 2.27e-9 Mosquito bite size; LUSC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg00310523 chr12:86230176 RASSF9 0.46 8.48 0.42 7.57e-16 Major depressive disorder; LUSC cis rs10887741 0.690 rs4934357 chr10:89439533 G/A cg24243914 chr10:89418206 PAPSS2 0.31 6.25 0.32 1.25e-9 Exercise (leisure time); LUSC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06544989 chr22:39130855 UNC84B -0.33 -5.74 -0.3 2.15e-8 Menopause (age at onset); LUSC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg10377582 chr12:51612794 POU6F1 -0.37 -5.93 -0.31 7.68e-9 Cisplatin-induced ototoxicity; LUSC cis rs4974559 0.594 rs11946384 chr4:1313566 T/C cg02980000 chr4:1222292 CTBP1 0.84 9.36 0.46 1.18e-18 Systolic blood pressure; LUSC cis rs10986311 0.832 rs748661 chr9:127095574 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.36 5.74 0.3 2.13e-8 Vitiligo; LUSC cis rs9815354 0.812 rs56290987 chr3:42004882 T/C cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg12165864 chr7:66369176 NA -0.52 -6.93 -0.35 2.19e-11 Corneal structure; LUSC cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg18252515 chr7:66147081 NA -1.22 -13.8 -0.6 1.31e-34 Diabetic kidney disease; LUSC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.83 0.35 3.99e-11 Hip circumference adjusted for BMI; LUSC cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs6750047 0.771 rs2855658 chr2:38296890 T/C cg07380506 chr2:38303506 CYP1B1 0.44 6.04 0.31 4.13e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg10978503 chr1:24200527 CNR2 -0.44 -9.16 -0.45 5.42e-18 Immature fraction of reticulocytes; LUSC cis rs1983891 1.000 rs9381082 chr6:41542214 T/C cg20194872 chr6:41519635 FOXP4 0.37 6.49 0.33 3.11e-10 Prostate cancer; LUSC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg22800045 chr5:56110881 MAP3K1 0.43 6.07 0.32 3.52e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs4285028 0.851 rs1986368 chr3:121710969 A/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -9.01 -0.44 1.58e-17 Multiple sclerosis; LUSC cis rs2952156 0.920 rs2517959 chr17:37846512 A/T cg20243544 chr17:37824526 PNMT 0.5 7.08 0.36 8.32e-12 Asthma; LUSC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg04800585 chr6:26043546 HIST1H2BB -0.41 -5.98 -0.31 5.79e-9 Intelligence (multi-trait analysis); LUSC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.73 -0.35 7.36e-11 Total body bone mineral density; LUSC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg17366294 chr4:99064904 C4orf37 0.59 10.54 0.5 1.24e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg03909863 chr11:638404 DRD4 -0.39 -5.74 -0.3 2.17e-8 Systemic lupus erythematosus; LUSC trans rs911555 0.723 rs2273701 chr14:103923225 G/T cg17675199 chr6:35436792 RPL10A -0.42 -6.16 -0.32 2.14e-9 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg20887711 chr4:1340912 KIAA1530 0.39 5.82 0.3 1.36e-8 Obesity-related traits; LUSC cis rs2486288 0.656 rs11632752 chr15:45551140 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.02e-14 Glomerular filtration rate; LUSC cis rs8017423 0.838 rs11845950 chr14:90723962 T/A cg14092571 chr14:90743983 NA -0.36 -5.82 -0.3 1.35e-8 Mortality in heart failure; LUSC cis rs12210905 0.688 rs9393814 chr6:27372978 C/T cg08851530 chr6:28072375 NA 0.97 6.41 0.33 4.91e-10 Hip circumference adjusted for BMI; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg07092213 chr7:1199455 ZFAND2A -0.55 -8.94 -0.44 2.72e-17 Longevity;Endometriosis; LUSC cis rs6546550 0.901 rs3771531 chr2:70164034 T/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.49 -0.38 6.3e-13 Prevalent atrial fibrillation; LUSC cis rs7615316 1.000 rs1916639 chr3:142346764 T/C cg16271453 chr3:142027066 XRN1 -0.34 -5.82 -0.3 1.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6815814 1.000 rs11722836 chr4:38811529 T/A cg02016764 chr4:38805732 TLR1 -0.54 -5.74 -0.3 2.17e-8 Breast cancer; LUSC cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 9.95 0.48 1.36e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7639513 0.767 rs2348201 chr3:12711696 A/G cg23032965 chr3:12705835 RAF1 0.76 11.5 0.53 5.11e-26 Itch intensity from mosquito bite; LUSC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg06713675 chr4:122721982 EXOSC9 -0.46 -8.07 -0.4 1.27e-14 Type 2 diabetes; LUSC cis rs6138458 1.000 rs227616 chr20:24908811 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.25 0.71 4.21e-52 Blood protein levels; LUSC cis rs113835537 0.935 rs79496339 chr11:66467769 T/A cg24851651 chr11:66362959 CCS 0.52 6.19 0.32 1.78e-9 Airway imaging phenotypes; LUSC cis rs9928842 0.882 rs1107593 chr16:75261329 G/C cg09066997 chr16:75300724 BCAR1 0.52 6.39 0.33 5.5e-10 Alcoholic chronic pancreatitis; LUSC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.31 -0.33 8.87e-10 Lung cancer; LUSC cis rs7769051 1.000 rs9493443 chr6:133121349 C/T cg07930552 chr6:133119739 C6orf192 0.79 10.32 0.49 7.22e-22 Type 2 diabetes nephropathy; LUSC cis rs11122272 0.735 rs973254 chr1:231521149 T/A cg06096015 chr1:231504339 EGLN1 0.56 9.82 0.47 3.68e-20 Hemoglobin concentration; LUSC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg14298792 chr15:30685198 CHRFAM7A -0.67 -8.7 -0.43 1.55e-16 Huntington's disease progression; LUSC trans rs7829975 0.714 rs11784052 chr8:8671962 C/T cg21775007 chr8:11205619 TDH 0.44 6.32 0.33 8.51e-10 Mood instability; LUSC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg22535103 chr8:58192502 C8orf71 -0.72 -7.78 -0.39 9.08e-14 Developmental language disorder (linguistic errors); LUSC cis rs2019216 0.500 rs1877497 chr17:21940171 C/T cg22648282 chr17:21454238 C17orf51 -0.49 -6.88 -0.35 2.93e-11 Pelvic organ prolapse; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg14705778 chr4:174254825 HMGB2 0.47 6.18 0.32 1.91e-9 Neuroticism; LUSC trans rs445114 0.527 rs606677 chr8:128334485 T/C cg10195415 chr17:73887371 TRIM65 0.41 6.57 0.34 1.93e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC trans rs61931739 0.534 rs11052986 chr12:34052578 T/C cg13010199 chr12:38710504 ALG10B 0.52 7.91 0.4 3.8e-14 Morning vs. evening chronotype; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03362053 chr11:74699895 NEU3 -0.48 -6.41 -0.33 4.97e-10 Hepatitis; LUSC cis rs9527 0.590 rs10883839 chr10:104920341 A/G cg05855489 chr10:104503620 C10orf26 0.47 6.24 0.32 1.31e-9 Arsenic metabolism; LUSC cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg10523679 chr1:76189770 ACADM -0.53 -7.87 -0.4 5.03e-14 Daytime sleep phenotypes; LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg03188948 chr7:1209495 NA 0.66 6.96 0.36 1.81e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg10792982 chr14:105748885 BRF1 0.52 9.22 0.45 3.53e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs2637266 1.000 rs10824429 chr10:78346196 G/T cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.54e-12 Pulmonary function; LUSC trans rs7824557 0.628 rs7820301 chr8:11228672 G/A cg06636001 chr8:8085503 FLJ10661 0.43 6.45 0.33 3.91e-10 Retinal vascular caliber; LUSC cis rs2282802 0.635 rs397463 chr5:139584275 C/G cg26211634 chr5:139558579 C5orf32 -0.42 -7.87 -0.4 5.06e-14 Intelligence (multi-trait analysis); LUSC cis rs8141529 0.719 rs5762825 chr22:29223642 A/G cg15103426 chr22:29168792 CCDC117 0.59 8.3 0.41 2.69e-15 Lymphocyte counts; LUSC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg11752832 chr7:134001865 SLC35B4 0.59 9.47 0.46 5.31e-19 Mean platelet volume; LUSC cis rs9790314 1.000 rs1382428 chr3:161032386 A/C cg04691961 chr3:161091175 C3orf57 -0.36 -6.12 -0.32 2.6e-9 Morning vs. evening chronotype; LUSC cis rs3092073 0.624 rs11696623 chr20:44580380 C/T cg17986701 chr20:44574422 PCIF1 0.38 6.7 0.34 8.99e-11 Intelligence (multi-trait analysis); LUSC cis rs952623 0.622 rs12667652 chr7:39074572 C/G cg15212455 chr7:39170539 POU6F2 0.36 5.96 0.31 6.42e-9 Intelligence (multi-trait analysis); LUSC cis rs9486719 1.000 rs12201449 chr6:96959382 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -10.0 -0.48 9.04e-21 Migraine;Coronary artery disease; LUSC cis rs9581857 0.547 rs76971629 chr13:28051031 C/T cg22138327 chr13:27999177 GTF3A 0.77 8.18 0.41 5.82e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.5 0.53 5.33e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg05347473 chr6:146136440 FBXO30 0.38 6.48 0.33 3.36e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7582720 1.000 rs72934740 chr2:203741362 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.54 0.42 4.75e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg03563238 chr19:33554763 RHPN2 -0.37 -6.29 -0.33 1.01e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg11645453 chr3:52864694 ITIH4 0.36 8.4 0.42 1.31e-15 Bipolar disorder; LUSC cis rs782590 0.967 rs1975487 chr2:55809054 A/G cg18811423 chr2:55921094 PNPT1 0.81 13.7 0.6 3.41e-34 Metabolic syndrome; LUSC cis rs9888739 1.000 rs9938063 chr16:31302938 C/T cg15817542 chr16:31343056 ITGAM 0.48 5.89 0.31 9.47e-9 Systemic lupus erythematosus; LUSC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg16049864 chr8:95962084 TP53INP1 -0.73 -14.1 -0.61 9.54e-36 Type 2 diabetes; LUSC cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.28 0.37 2.34e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg09323728 chr8:95962352 TP53INP1 -0.37 -7.6 -0.38 3.05e-13 Type 2 diabetes; LUSC cis rs6665290 0.935 rs11588904 chr1:227196211 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -40.37 -0.91 1.58e-130 Myeloid white cell count; LUSC cis rs9388451 0.839 rs3966775 chr6:126067655 C/A cg05901451 chr6:126070800 HEY2 -0.95 -18.74 -0.72 4.51e-54 Brugada syndrome; LUSC cis rs2073300 1.000 rs6137977 chr20:23464191 G/T cg09953122 chr20:23471693 CST8 -0.88 -7.54 -0.38 4.52e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2235642 0.750 rs763152 chr16:1658056 T/C cg09025071 chr16:1593152 IFT140;TMEM204 0.33 7.66 0.39 2.05e-13 Coronary artery disease; LUSC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg06221963 chr1:154839813 KCNN3 -0.6 -13.38 -0.59 5.65e-33 Prostate cancer; LUSC cis rs2455601 1.000 rs12418190 chr11:8899818 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -7.54 -0.38 4.43e-13 Schizophrenia; LUSC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg03806693 chr22:41940476 POLR3H -1.05 -14.81 -0.63 1.65e-38 Vitiligo; LUSC trans rs11088226 0.581 rs7282335 chr21:33905919 A/G cg09050820 chr6:167586206 TCP10L2 0.54 8.09 0.4 1.14e-14 Gastritis; LUSC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg02423579 chr7:2872169 GNA12 -0.39 -5.75 -0.3 1.98e-8 Height; LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg26119090 chr2:26468346 HADHA;HADHB -1.09 -16.93 -0.68 7.7e-47 Gut microbiome composition (summer); LUSC cis rs12421382 0.659 rs12420684 chr11:109391788 T/C cg27471124 chr11:109292789 C11orf87 0.43 7.64 0.39 2.36e-13 Schizophrenia; LUSC cis rs11971779 0.588 rs6972408 chr7:139071474 T/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs4499344 0.730 rs406470 chr19:33104472 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.83 12.77 0.57 1.14e-30 Mean platelet volume; LUSC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg03785755 chr6:26196794 NA 0.53 5.67 0.3 3.12e-8 Gout;Renal underexcretion gout; LUSC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg19266014 chr7:2183958 MAD1L1 -0.35 -5.76 -0.3 1.88e-8 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg13206674 chr6:150067644 NUP43 0.59 9.36 0.46 1.17e-18 Lung cancer; LUSC cis rs16917546 1.000 rs7090073 chr10:64423505 G/T cg03961010 chr10:64397487 ZNF365 -0.41 -6.4 -0.33 5.32e-10 Basal cell carcinoma; LUSC cis rs12541635 0.966 rs62525734 chr8:106984056 T/C cg10147462 chr8:107024639 NA 0.55 9.54 0.46 3.03e-19 Age of smoking initiation; LUSC trans rs7829975 0.606 rs6422352 chr8:8794193 A/G cg27411982 chr8:10470053 RP1L1 -0.36 -6.05 -0.31 3.93e-9 Mood instability; LUSC cis rs3136441 1.000 rs2306033 chr11:46897446 G/A cg01183595 chr11:46746236 F2 0.39 5.91 0.31 8.67e-9 HDL cholesterol; LUSC cis rs34779708 0.931 rs4934693 chr10:35271844 G/A cg04310649 chr10:35416472 CREM -0.42 -6.39 -0.33 5.6e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.46 -6.53 -0.34 2.49e-10 Monocyte percentage of white cells; LUSC cis rs4561483 0.832 rs171656 chr16:11953167 C/T cg08843971 chr16:11963173 GSPT1 -0.48 -7.19 -0.37 4.34e-12 Testicular germ cell tumor; LUSC cis rs3892630 0.588 rs2112917 chr19:33317543 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.51 -5.79 -0.3 1.58e-8 Red blood cell traits; LUSC cis rs2109514 1.000 rs7795510 chr7:116156961 T/C cg12739419 chr7:116140593 CAV2 -0.28 -6.24 -0.32 1.32e-9 Prevalent atrial fibrillation; LUSC cis rs7937682 0.924 rs10891284 chr11:111527737 T/C cg19812747 chr11:111475976 SIK2 -0.48 -6.84 -0.35 3.87e-11 Primary sclerosing cholangitis; LUSC cis rs360798 0.532 rs11125942 chr2:62966758 T/C cg17519650 chr2:63277830 OTX1 -0.47 -6.58 -0.34 1.78e-10 Coronary artery disease; LUSC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg00074818 chr8:8560427 CLDN23 0.57 9.67 0.47 1.14e-19 Obesity-related traits; LUSC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg09509183 chr1:209979624 IRF6 0.5 5.9 0.31 8.79e-9 Cleft lip with or without cleft palate; LUSC cis rs59918340 0.728 rs4961340 chr8:142232002 G/A cg23750338 chr8:142222470 SLC45A4 0.58 11.26 0.52 3.68e-25 Immature fraction of reticulocytes; LUSC cis rs1595825 0.891 rs6733834 chr2:198518709 C/G cg00982548 chr2:198649783 BOLL 0.51 6.45 0.33 3.95e-10 Ulcerative colitis; LUSC cis rs6754311 0.731 rs309164 chr2:136691825 T/C cg07169764 chr2:136633963 MCM6 0.68 9.86 0.47 2.7e-20 Mosquito bite size; LUSC cis rs8114671 0.647 rs1124511 chr20:33736697 A/C cg24642439 chr20:33292090 TP53INP2 0.4 5.75 0.3 2.02e-8 Height; LUSC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg08847533 chr14:75593920 NEK9 -0.82 -15.3 -0.64 1.96e-40 Height; LUSC cis rs1348850 0.918 rs12622298 chr2:178450651 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 6.4 0.33 5.29e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg05025164 chr4:1340916 KIAA1530 0.54 8.42 0.42 1.1e-15 Obesity-related traits; LUSC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.9 0.35 2.55e-11 Tonsillectomy; LUSC cis rs9517320 1.000 rs912337 chr13:99141272 A/G cg20487152 chr13:99095054 FARP1 -0.38 -7.1 -0.36 7.47e-12 Longevity; LUSC cis rs9790314 0.586 rs11710916 chr3:161130070 A/G cg03342759 chr3:160939853 NMD3 -0.43 -7.08 -0.36 8.65e-12 Morning vs. evening chronotype; LUSC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg04369109 chr6:150039330 LATS1 -0.53 -7.51 -0.38 5.43e-13 Lung cancer; LUSC cis rs2835872 0.863 rs857979 chr21:38998093 A/G cg20424643 chr21:39039972 KCNJ6 -0.38 -5.89 -0.31 9.27e-9 Electroencephalographic traits in alcoholism; LUSC cis rs55675132 0.667 rs1539571 chr1:115634729 C/T cg01522456 chr1:115632236 TSPAN2 0.47 6.52 0.34 2.53e-10 Schizophrenia; LUSC cis rs9875589 0.509 rs7614591 chr3:14061118 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.17 0.37 4.91e-12 Ovarian reserve; LUSC cis rs4774899 0.837 rs11852340 chr15:57402690 C/T cg21617494 chr15:57618479 NA -0.33 -5.68 -0.3 2.94e-8 Urinary tract infection frequency; LUSC cis rs7267979 1.000 rs4815412 chr20:25350325 A/G cg08601574 chr20:25228251 PYGB 0.43 6.58 0.34 1.87e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs778371 0.723 rs13001052 chr2:233683984 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -12.25 -0.56 9.29e-29 Schizophrenia; LUSC cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg24812749 chr6:127587940 RNF146 0.92 13.89 0.61 6.05e-35 Breast cancer; LUSC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Urate levels; LUSC cis rs68170813 0.559 rs12533767 chr7:106860245 A/C cg02696742 chr7:106810147 HBP1 -0.64 -9.58 -0.46 2.35e-19 Coronary artery disease; LUSC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.71e-13 Electroencephalogram traits; LUSC cis rs1448094 0.935 rs4919775 chr12:86339985 T/C cg02569458 chr12:86230093 RASSF9 0.42 6.85 0.35 3.49e-11 Major depressive disorder; LUSC trans rs1925953 1.000 rs1925953 chr1:68848681 A/T cg11413152 chr1:44687590 ERI3 -0.36 -6.21 -0.32 1.58e-9 Vertical cup-disc ratio; LUSC cis rs2445762 0.659 rs12443032 chr15:51670305 T/C cg07517944 chr15:51633816 GLDN 0.39 6.6 0.34 1.57e-10 Hormone measurements; LUSC cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg09184832 chr6:79620586 NA -0.44 -7.23 -0.37 3.26e-12 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg04267008 chr7:1944627 MAD1L1 -0.67 -10.16 -0.49 2.52e-21 Bipolar disorder and schizophrenia; LUSC cis rs2011503 0.509 rs73006705 chr19:19781917 A/G cg11584989 chr19:19387371 SF4 0.51 5.82 0.3 1.41e-8 Bipolar disorder; LUSC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg22800045 chr5:56110881 MAP3K1 0.47 6.19 0.32 1.78e-9 Coronary artery disease; LUSC cis rs6754311 0.681 rs4954493 chr2:136609975 T/C cg25344623 chr2:136566232 LCT 0.4 5.99 0.31 5.57e-9 Mosquito bite size; LUSC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs9420 0.922 rs35808061 chr11:57547000 T/C cg23127183 chr11:57508653 C11orf31 -0.57 -8.81 -0.43 6.86e-17 Schizophrenia; LUSC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg17385448 chr1:15911702 AGMAT -0.34 -5.74 -0.3 2.09e-8 Systolic blood pressure; LUSC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg19052272 chr2:3704530 ALLC -0.33 -6.33 -0.33 7.72e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs8044995 0.501 rs7189887 chr16:68353915 C/T cg09835421 chr16:68378352 PRMT7 -0.8 -8.49 -0.42 6.81e-16 Schizophrenia; LUSC cis rs8044868 0.586 rs10852511 chr16:72183959 G/A cg16579770 chr16:72058938 DHODH 0.36 5.83 0.3 1.28e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg10356904 chr22:49881777 NA -0.31 -6.98 -0.36 1.58e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10078 0.571 rs2561664 chr5:459793 T/C cg08916839 chr5:415575 AHRR 0.75 7.09 0.36 7.88e-12 Fat distribution (HIV); LUSC cis rs3820928 0.967 rs4675118 chr2:227773157 C/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.8 -0.39 8.04e-14 Pulmonary function; LUSC cis rs79349575 0.729 rs62075824 chr17:46986679 A/G cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.82e-13 Type 2 diabetes; LUSC cis rs951366 0.576 rs11240561 chr1:205712957 T/G cg07167872 chr1:205819463 PM20D1 -0.44 -5.94 -0.31 7.24e-9 Menarche (age at onset); LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg26338869 chr17:61819248 STRADA 0.41 5.95 0.31 6.61e-9 Prudent dietary pattern; LUSC cis rs4588572 0.643 rs10043115 chr5:77692019 T/C cg11547950 chr5:77652471 NA 0.51 7.55 0.38 4.17e-13 Triglycerides; LUSC cis rs1003719 0.679 rs1133001 chr21:38512956 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.52 -0.5 1.49e-22 Eye color traits; LUSC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs11030122 0.702 rs10835311 chr11:3949027 G/T cg18678763 chr11:4115507 RRM1 -0.45 -5.82 -0.3 1.37e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs7851660 0.654 rs2120264 chr9:100645728 A/G cg13688889 chr9:100608707 NA -0.56 -8.56 -0.42 4.06e-16 Strep throat; LUSC cis rs9326248 0.861 rs4938353 chr11:117046197 G/A cg26566898 chr11:117069891 TAGLN 0.38 6.21 0.32 1.62e-9 Blood protein levels; LUSC cis rs78366141 0.649 rs7666372 chr4:89687531 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.88 7.46 0.38 7.32e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg24829409 chr8:58192753 C8orf71 -0.53 -6.17 -0.32 1.98e-9 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg02475777 chr4:1388615 CRIPAK -0.57 -8.7 -0.43 1.49e-16 Obesity-related traits; LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 6.38 0.33 5.95e-10 Bipolar disorder; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg07362569 chr17:61921086 SMARCD2 0.38 7.98 0.4 2.33e-14 Prudent dietary pattern; LUSC cis rs9300255 0.602 rs1727313 chr12:123640853 C/G cg00376283 chr12:123451042 ABCB9 0.66 7.62 0.38 2.6e-13 Neutrophil percentage of white cells; LUSC cis rs9326248 0.509 rs533556 chr11:116741572 A/C cg01368799 chr11:117014884 PAFAH1B2 0.56 8.61 0.43 3e-16 Blood protein levels; LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs17767294 1.000 rs17767294 chr6:28054198 A/G cg08851530 chr6:28072375 NA 0.9 5.83 0.3 1.34e-8 Parkinson's disease; LUSC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC cis rs644799 0.648 rs1255182 chr11:95472391 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.5 7.25 0.37 2.95e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3806843 1.000 rs6898906 chr5:140169299 C/G cg19875535 chr5:140030758 IK 0.51 8.37 0.42 1.55e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs62400317 0.859 rs12211519 chr6:45160530 C/A cg20913747 chr6:44695427 NA -0.48 -7.7 -0.39 1.56e-13 Total body bone mineral density; LUSC cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg06627628 chr2:24431161 ITSN2 -0.58 -7.15 -0.36 5.66e-12 Lymphocyte counts; LUSC cis rs62400317 0.859 rs12191262 chr6:45227016 G/A cg20913747 chr6:44695427 NA -0.49 -7.92 -0.4 3.53e-14 Total body bone mineral density; LUSC cis rs2806561 0.734 rs2806564 chr1:23506685 T/C cg12483005 chr1:23474871 LUZP1 0.41 6.31 0.33 8.89e-10 Height; LUSC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg24675056 chr1:15929824 NA 0.48 8.33 0.41 2.17e-15 Systolic blood pressure; LUSC cis rs4073582 0.595 rs1115508 chr11:65923149 A/G cg16950941 chr11:66035639 RAB1B 0.5 7.27 0.37 2.57e-12 Gout; LUSC cis rs12579753 0.879 rs35087297 chr12:82133398 C/T cg21231944 chr12:82153410 PPFIA2 -0.4 -6.17 -0.32 1.98e-9 Resting heart rate; LUSC cis rs611744 0.624 rs2514844 chr8:109064809 A/G cg18478394 chr8:109455254 TTC35 0.41 6.01 0.31 4.98e-9 Dupuytren's disease; LUSC cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg08999081 chr20:33150536 PIGU 0.52 10.42 0.5 3.46e-22 Glomerular filtration rate (creatinine); LUSC cis rs7909074 0.832 rs10793564 chr10:45386352 C/A cg04218760 chr10:45406644 TMEM72 -0.29 -7.05 -0.36 1.06e-11 Mean corpuscular volume; LUSC cis rs240764 0.782 rs395521 chr6:101054999 C/T cg09795085 chr6:101329169 ASCC3 0.41 6.01 0.31 4.84e-9 Neuroticism; LUSC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg03808351 chr9:123631620 PHF19 -0.42 -6.68 -0.34 1e-10 Birth weight; LUSC cis rs6500395 1.000 rs1872655 chr16:48670883 A/C cg04672837 chr16:48644449 N4BP1 0.46 6.91 0.35 2.41e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6696846 0.749 rs61822566 chr1:205078660 T/C cg00857998 chr1:205179979 DSTYK 0.61 9.85 0.47 2.83e-20 Red blood cell count; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg25348504 chr12:111180878 PPP1CC 0.49 6.31 0.33 9.05e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg04450456 chr4:17643702 FAM184B 0.41 6.89 0.35 2.83e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7715806 0.500 rs72633986 chr5:75006449 T/A cg19683494 chr5:74908142 NA 0.57 7.68 0.39 1.83e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9902453 0.967 rs34323226 chr17:28517454 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.84 0.44 5.69e-17 Coffee consumption (cups per day); LUSC cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg25427524 chr10:38739819 LOC399744 -0.74 -13.93 -0.61 4.43e-35 Extrinsic epigenetic age acceleration; LUSC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg19592336 chr6:28129416 ZNF389 0.48 6.27 0.32 1.11e-9 Depression; LUSC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.79e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg15468180 chr1:107600409 PRMT6 -0.38 -6.1 -0.32 3.01e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs7824557 0.606 rs2736273 chr8:11199938 C/A cg27411982 chr8:10470053 RP1L1 0.4 6.1 0.32 3e-9 Retinal vascular caliber; LUSC trans rs561341 1.000 rs554078 chr17:30330109 A/C cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.89 -0.31 9.55e-9 Platelet count; LUSC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg13206674 chr6:150067644 NUP43 0.55 8.68 0.43 1.72e-16 Lung cancer; LUSC trans rs12429206 0.520 rs1870839 chr13:51473868 A/G cg00778807 chr1:43524347 NA -0.35 -5.98 -0.31 5.77e-9 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs611744 0.604 rs13248461 chr8:109285833 C/T cg21045802 chr8:109455806 TTC35 0.44 6.89 0.35 2.71e-11 Dupuytren's disease; LUSC cis rs61931739 0.500 rs6488224 chr12:34537205 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs500891 0.645 rs1170502 chr6:83991972 A/T cg08257003 chr6:84140564 ME1 0.33 7.15 0.36 5.67e-12 Platelet-derived growth factor BB levels; LUSC cis rs6516091 0.778 rs62199231 chr20:6050133 C/T cg25325723 chr20:6104886 FERMT1 -0.65 -7.0 -0.36 1.39e-11 Abdominal aortic aneurysm; LUSC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.57e-10 Melanoma; LUSC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg23283495 chr1:209979779 IRF6 0.46 7.41 0.38 1.02e-12 Monobrow; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg06145435 chr7:1022769 CYP2W1 0.27 5.84 0.3 1.25e-8 Longevity;Endometriosis; LUSC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg06740227 chr12:86229804 RASSF9 0.45 7.16 0.36 5.25e-12 Major depressive disorder; LUSC cis rs4629710 0.592 rs11759926 chr6:131571269 G/T cg12700074 chr6:131571435 AKAP7 -0.36 -5.94 -0.31 7.17e-9 Multiple myeloma (IgH translocation); LUSC cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs1670533 1.000 rs1670534 chr4:1087265 T/C cg27284194 chr4:1044797 NA 0.57 8.29 0.41 2.83e-15 Recombination rate (females); LUSC cis rs11997175 1.000 rs7464996 chr8:33770925 G/T ch.8.33884649F chr8:33765107 NA 0.53 8.5 0.42 6.26e-16 Body mass index; LUSC cis rs2806561 0.704 rs674386 chr1:23521835 G/A cg19743168 chr1:23544995 NA 0.46 9.11 0.45 8.03e-18 Height; LUSC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg22782873 chr19:19639568 YJEFN3 -0.5 -6.41 -0.33 5.05e-10 Bipolar disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22524267 chr4:4543474 STX18 0.41 6.34 0.33 7.47e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs6601327 0.575 rs7001832 chr8:9607235 C/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.95 -0.36 1.88e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs11098499 0.909 rs28571712 chr4:120375980 G/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs868036 0.718 rs7170185 chr15:68117300 T/A cg08079166 chr15:68083412 MAP2K5 0.41 7.27 0.37 2.57e-12 Restless legs syndrome; LUSC cis rs7267979 1.000 rs7268053 chr20:25328286 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.56 -0.75 2.74e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1003719 0.614 rs1053808 chr21:38525356 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -9.36 -0.46 1.23e-18 Eye color traits; LUSC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg08859206 chr1:53392774 SCP2 -0.56 -9.64 -0.47 1.48e-19 Monocyte count; LUSC cis rs6964587 1.000 rs733957 chr7:91707197 C/T cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.5e-8 Breast cancer; LUSC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg06634786 chr22:41940651 POLR3H 0.48 5.65 0.3 3.35e-8 Vitiligo; LUSC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg05025164 chr4:1340916 KIAA1530 0.39 6.05 0.31 3.95e-9 Obesity-related traits; LUSC cis rs2637266 1.000 rs1907317 chr10:78337849 C/A cg18941641 chr10:78392320 NA 0.36 6.52 0.34 2.65e-10 Pulmonary function; LUSC cis rs3809566 1.000 rs4774471 chr15:63332645 A/T cg00520135 chr15:63333846 TPM1 0.33 6.75 0.35 6.7e-11 Platelet count; LUSC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg19046167 chr17:80928561 B3GNTL1 0.4 6.46 0.33 3.81e-10 Breast cancer; LUSC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg22508957 chr16:3507546 NAT15 -0.92 -10.6 -0.5 7.89e-23 Tuberculosis; LUSC cis rs8077889 1.000 rs17742905 chr17:41891143 C/A cg26893861 chr17:41843967 DUSP3 0.96 14.6 0.62 1.15e-37 Triglycerides; LUSC cis rs6740322 0.748 rs6755601 chr2:43483044 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.05 -0.36 1.01e-11 Coronary artery disease; LUSC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg14552801 chr7:65878734 NA 0.46 6.44 0.33 4.06e-10 Aortic root size; LUSC cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.53e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.3 0.41 2.53e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4594175 0.926 rs11157803 chr14:51627700 C/T cg23942311 chr14:51606299 NA 0.31 5.88 0.31 9.94e-9 Cancer; LUSC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -8.18 -0.41 5.97e-15 Body mass index (adult); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26880762 chr12:123943063 SNRNP35 0.44 6.56 0.34 2.05e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11785400 0.762 rs7017931 chr8:143726728 A/G cg10596483 chr8:143751796 JRK 0.52 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg03806693 chr22:41940476 POLR3H 0.99 13.81 0.6 1.28e-34 Vitiligo; LUSC trans rs6480314 0.542 rs61854824 chr10:70030195 C/T cg04882175 chr6:131122610 NA -0.54 -6.15 -0.32 2.17e-9 Optic nerve measurement (disc area); LUSC cis rs4664308 1.000 rs1511218 chr2:160906390 T/C cg03641300 chr2:160917029 PLA2R1 -0.66 -11.21 -0.52 5.69e-25 Idiopathic membranous nephropathy; LUSC cis rs3750965 0.920 rs10896421 chr11:68863048 T/C cg06818126 chr11:68850279 TPCN2 -0.43 -6.37 -0.33 6.24e-10 Hair color; LUSC cis rs7726839 0.718 rs6887972 chr5:597274 C/G cg16447950 chr5:562315 NA -0.47 -6.36 -0.33 6.51e-10 Obesity-related traits; LUSC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.62 0.34 1.45e-10 Melanoma; LUSC cis rs4706831 0.647 rs627240 chr6:80985885 C/A cg08355045 chr6:80787529 NA -0.41 -7.07 -0.36 9.25e-12 Joint mobility (Beighton score); LUSC cis rs6500395 0.802 rs13330784 chr16:48661530 A/C cg04672837 chr16:48644449 N4BP1 0.46 6.97 0.36 1.7e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.83 -11.19 -0.52 6.51e-25 Schizophrenia; LUSC cis rs8017423 0.935 rs11626869 chr14:90788985 A/G cg04374321 chr14:90722782 PSMC1 -0.65 -9.58 -0.46 2.35e-19 Mortality in heart failure; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg01171360 chr6:293285 DUSP22 -0.53 -8.05 -0.4 1.43e-14 Menopause (age at onset); LUSC trans rs12458462 0.892 rs2242175 chr18:77464406 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.81 -0.35 4.63e-11 Monocyte count; LUSC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg14664628 chr15:75095509 CSK -0.54 -7.97 -0.4 2.61e-14 Breast cancer; LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.85 0.47 2.98e-20 Bipolar disorder; LUSC cis rs7267979 0.966 rs2263204 chr20:25377688 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.83 -0.7 1.98e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg05025164 chr4:1340916 KIAA1530 0.53 8.44 0.42 9.73e-16 Longevity; LUSC cis rs77140172 0.677 rs28435799 chr4:89617931 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 1.0 7.23 0.37 3.23e-12 Post bronchodilator FEV1; LUSC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg20503657 chr10:835505 NA -0.77 -9.59 -0.46 2.07e-19 Eosinophil percentage of granulocytes; LUSC cis rs7577696 0.924 rs7561519 chr2:32312700 T/C cg02381751 chr2:32503542 YIPF4 -0.4 -5.76 -0.3 1.92e-8 Inflammatory biomarkers; LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18301423 chr5:131593218 PDLIM4 -0.49 -7.58 -0.38 3.52e-13 Acylcarnitine levels; LUSC cis rs244731 1.000 rs244730 chr5:176539212 A/G cg06060754 chr5:176797920 RGS14 -0.55 -8.05 -0.4 1.5e-14 Urate levels in lean individuals; LUSC cis rs713587 0.713 rs11682135 chr2:25205377 G/A cg01884057 chr2:25150051 NA -0.38 -8.58 -0.42 3.67e-16 Body mass index in non-asthmatics; LUSC cis rs7119 0.717 rs12901100 chr15:77815558 T/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs1003719 0.646 rs2032063 chr21:38576657 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg26566898 chr11:117069891 TAGLN 0.47 8.15 0.41 7.46e-15 Blood protein levels; LUSC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg26727032 chr16:67993705 SLC12A4 -0.44 -5.9 -0.31 8.7e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs11031096 0.711 rs1348309 chr11:4202000 A/T cg18678763 chr11:4115507 RRM1 -0.41 -5.8 -0.3 1.51e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg09365446 chr1:150670422 GOLPH3L 0.45 6.54 0.34 2.25e-10 Melanoma; LUSC cis rs6500395 0.962 rs7199625 chr16:48650217 G/C cg04672837 chr16:48644449 N4BP1 0.47 6.73 0.35 7.28e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9807989 0.839 rs1420099 chr2:102980543 C/G cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs727505 0.866 rs66852389 chr7:124724348 T/A cg23710748 chr7:124431027 NA -0.4 -6.96 -0.36 1.79e-11 Lewy body disease; LUSC cis rs57244997 0.860 rs9458425 chr6:162376946 C/T cg17173639 chr6:162384350 PARK2 -0.59 -6.3 -0.33 9.55e-10 Mosquito bite size; LUSC cis rs6967385 0.560 rs2192833 chr7:12355303 A/T cg06484146 chr7:12443880 VWDE 0.47 7.11 0.36 7.24e-12 Response to taxane treatment (placlitaxel); LUSC cis rs6546550 0.901 rs6546558 chr2:70145717 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.18e-12 Prevalent atrial fibrillation; LUSC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg12560992 chr17:57184187 TRIM37 -0.85 -15.42 -0.64 6.9e-41 Intelligence (multi-trait analysis); LUSC cis rs3931020 0.657 rs10890142 chr1:75179129 G/A cg10128416 chr1:75198403 TYW3;CRYZ 0.63 8.37 0.42 1.62e-15 Resistin levels; LUSC cis rs9436747 0.680 rs1171268 chr1:65996166 G/T cg14976592 chr1:65886160 LEPROT;LEPR -0.43 -5.83 -0.3 1.29e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs9479482 0.967 rs34006533 chr6:150350574 C/A cg00432049 chr6:150390894 ULBP3 -0.27 -5.76 -0.3 1.93e-8 Alopecia areata; LUSC cis rs2839186 0.869 rs17176513 chr21:47682428 A/G cg13012494 chr21:47604986 C21orf56 0.4 5.93 0.31 7.68e-9 Testicular germ cell tumor; LUSC cis rs2219968 1.000 rs4333586 chr8:78971965 C/T cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4132509 1.000 rs2290754 chr1:243806268 A/C cg21452805 chr1:244014465 NA 0.49 5.86 0.31 1.11e-8 RR interval (heart rate); LUSC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg06112835 chr11:68658793 MRPL21 0.52 8.19 0.41 5.43e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1784581 0.802 rs7768986 chr6:162427890 G/C cg17173639 chr6:162384350 PARK2 0.66 11.67 0.54 1.27e-26 Itch intensity from mosquito bite; LUSC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg20203395 chr5:56204925 C5orf35 -0.73 -9.82 -0.47 3.59e-20 Initial pursuit acceleration; LUSC cis rs7582180 0.629 rs34745556 chr2:100942506 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.6 -0.43 3.22e-16 Intelligence (multi-trait analysis); LUSC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg14500267 chr11:67383377 NA 0.45 8.91 0.44 3.43e-17 Mean corpuscular volume; LUSC trans rs867371 0.722 rs8033050 chr15:82561989 G/A cg18393722 chr15:85113863 UBE2QP1 -0.48 -7.16 -0.36 5.28e-12 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs7577696 0.597 rs375050 chr2:32413765 C/T cg02381751 chr2:32503542 YIPF4 0.53 7.13 0.36 6.44e-12 Inflammatory biomarkers; LUSC cis rs2274273 0.870 rs11625001 chr14:55758160 T/C cg04306507 chr14:55594613 LGALS3 0.54 12.05 0.55 5.23e-28 Protein biomarker; LUSC cis rs6430585 0.527 rs62168792 chr2:136415217 A/G cg07169764 chr2:136633963 MCM6 1.04 13.97 0.61 3.08e-35 Corneal structure; LUSC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg06363034 chr20:62225388 GMEB2 -0.46 -7.67 -0.39 1.92e-13 Glioblastoma; LUSC cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.71 0.43 1.47e-16 Lung cancer in ever smokers; LUSC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg21466736 chr12:48725269 NA -0.32 -6.0 -0.31 5.12e-9 Bipolar disorder and schizophrenia; LUSC cis rs72781680 0.821 rs72796369 chr2:24162663 G/T cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg22800045 chr5:56110881 MAP3K1 -0.6 -8.43 -0.42 1.06e-15 Initial pursuit acceleration; LUSC cis rs3126085 0.935 rs12729662 chr1:152185750 G/A cg26876637 chr1:152193138 HRNR -0.41 -5.73 -0.3 2.23e-8 Atopic dermatitis; LUSC cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19346786 chr7:2764209 NA -0.47 -7.74 -0.39 1.22e-13 Height; LUSC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg04414720 chr1:150670196 GOLPH3L 0.58 9.26 0.45 2.51e-18 Tonsillectomy; LUSC cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg08514558 chr10:81106712 PPIF 0.27 5.87 0.31 1.03e-8 Height; LUSC cis rs3772130 0.923 rs3805127 chr3:121556751 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.67 9.66 0.47 1.25e-19 Cognitive performance; LUSC cis rs478304 0.651 rs948494 chr11:65552118 G/A cg10518572 chr11:65560635 OVOL1 -0.27 -6.2 -0.32 1.71e-9 Acne (severe); LUSC cis rs478304 0.651 rs11604462 chr11:65551648 G/A cg05805236 chr11:65401703 PCNXL3 -0.56 -8.82 -0.43 6.65e-17 Acne (severe); LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg11645453 chr3:52864694 ITIH4 0.38 8.65 0.43 2.25e-16 Bipolar disorder; LUSC cis rs7202877 0.706 rs4888375 chr16:75322356 T/C cg03315344 chr16:75512273 CHST6 0.42 6.19 0.32 1.72e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7949030 1.000 rs2956993 chr11:62406162 G/T cg22862634 chr11:62369728 EML3;MTA2 -0.49 -8.02 -0.4 1.82e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.94 0.4 3.18e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs965469 1.000 rs2236122 chr20:3305240 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -5.69 -0.3 2.84e-8 IFN-related cytopenia; LUSC cis rs9462027 0.628 rs2814945 chr6:34647978 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.21 -0.32 1.53e-9 Systemic lupus erythematosus; LUSC cis rs1371867 0.846 rs1660316 chr8:101333049 T/C cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg16423285 chr20:60520624 NA -0.63 -8.09 -0.4 1.11e-14 Body mass index; LUSC cis rs9486719 1.000 rs11752584 chr6:96884952 C/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg04518342 chr5:131593106 PDLIM4 0.42 8.07 0.4 1.29e-14 Blood metabolite levels; LUSC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg09365446 chr1:150670422 GOLPH3L -0.48 -7.11 -0.36 7.23e-12 Melanoma; LUSC trans rs1941687 0.702 rs4392137 chr18:31316708 T/C cg27147174 chr7:100797783 AP1S1 -0.46 -6.61 -0.34 1.56e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2573652 1.000 rs1469829 chr15:100517332 A/G cg09918751 chr15:100517450 ADAMTS17 -0.46 -8.82 -0.43 6.47e-17 Height; LUSC cis rs897984 0.572 rs112906665 chr16:31040139 T/C cg02466173 chr16:30829666 NA -0.52 -10.2 -0.49 1.98e-21 Dementia with Lewy bodies; LUSC trans rs11722228 0.522 rs1109472 chr4:10134448 C/G cg26043149 chr18:55253948 FECH 0.97 16.58 0.67 1.87e-45 Gout;Urate levels;Serum uric acid levels; LUSC trans rs4332037 0.539 rs34809719 chr7:2028968 G/T cg11693508 chr17:37793320 STARD3 0.6 7.06 0.36 9.73e-12 Bipolar disorder; LUSC cis rs7582720 1.000 rs72934513 chr2:203927587 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs262150 0.672 rs2730230 chr7:158788529 A/G cg19418458 chr7:158789849 NA -0.53 -7.99 -0.4 2.2e-14 Facial morphology (factor 20); LUSC cis rs1413885 0.549 rs7545720 chr1:65856443 G/T cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.89 0.35 2.73e-11 Anticoagulant levels; LUSC cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs1008375 0.800 rs35463363 chr4:17613423 G/T cg18681998 chr4:17616180 MED28 0.84 14.39 0.62 7.19e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg16524733 chr11:117070046 TAGLN 0.43 7.28 0.37 2.49e-12 Blood protein levels; LUSC trans rs11098499 0.754 rs2964 chr4:120240131 T/C cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs11229555 0.609 rs12273517 chr11:58201094 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2067615 0.524 rs1922436 chr12:107065258 A/G cg15890332 chr12:107067104 RFX4 0.33 5.9 0.31 8.75e-9 Heart rate; LUSC cis rs7512552 0.839 rs698916 chr1:150388385 A/G cg15654264 chr1:150340011 RPRD2 0.61 10.15 0.49 2.84e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg18230493 chr5:56204884 C5orf35 -0.81 -9.42 -0.46 7.53e-19 Type 2 diabetes; LUSC cis rs2137920 0.945 rs1877805 chr10:50234345 A/G cg27141751 chr10:50231850 C10orf72 -0.37 -5.86 -0.31 1.09e-8 Migraine with aura; LUSC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg00310523 chr12:86230176 RASSF9 0.44 7.75 0.39 1.12e-13 Major depressive disorder; LUSC trans rs561341 0.739 rs9906455 chr17:30215669 G/A cg20587970 chr11:113659929 NA 0.77 9.81 0.47 3.96e-20 Hip circumference adjusted for BMI; LUSC cis rs7605827 0.704 rs62120513 chr2:15537727 T/A cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs7100689 0.784 rs3802638 chr10:82179689 T/C cg00277334 chr10:82204260 NA -0.54 -7.29 -0.37 2.28e-12 Post bronchodilator FEV1; LUSC cis rs73198271 0.515 rs75660006 chr8:8619594 C/T cg01851573 chr8:8652454 MFHAS1 0.63 7.22 0.37 3.47e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg00071950 chr4:10020882 SLC2A9 -0.5 -8.34 -0.42 1.96e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC cis rs9314323 0.798 rs2019239 chr8:26217354 G/A cg11498726 chr8:26250323 BNIP3L -0.43 -6.24 -0.32 1.3e-9 Red cell distribution width; LUSC trans rs2262909 0.849 rs10420483 chr19:22190378 A/G cg05197062 chr11:11642011 GALNTL4 -0.52 -7.15 -0.36 5.63e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6456156 0.586 rs12528689 chr6:167461746 A/G cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs7568458 0.870 rs1009 chr2:85808737 A/G cg23752985 chr2:85803571 VAMP8 0.35 7.72 0.39 1.33e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg05043794 chr9:111880884 C9orf5 -0.35 -7.46 -0.38 7.48e-13 Menarche (age at onset); LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg03929089 chr4:120376271 NA -1.0 -18.17 -0.71 8.92e-52 Height; LUSC cis rs12956009 0.583 rs9653018 chr18:44895853 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.44 0.33 4.13e-10 Educational attainment (years of education); LUSC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.82 0.68 1.93e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10979 0.597 rs9399449 chr6:143908376 C/T cg25407410 chr6:143891975 LOC285740 -0.65 -8.19 -0.41 5.6e-15 Hypospadias; LUSC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg03929089 chr4:120376271 NA -0.94 -16.13 -0.66 1.07e-43 Height; LUSC cis rs870825 0.929 rs72689278 chr4:185593718 C/T cg04058563 chr4:185651563 MLF1IP 0.87 12.31 0.56 5.94e-29 Blood protein levels; LUSC cis rs478304 0.654 rs10896035 chr11:65461160 G/A cg27068330 chr11:65405492 SIPA1 -0.74 -10.29 -0.49 9.68e-22 Acne (severe); LUSC trans rs61931739 0.620 rs61927757 chr12:33710109 A/G cg26384229 chr12:38710491 ALG10B -0.42 -6.12 -0.32 2.68e-9 Morning vs. evening chronotype; LUSC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg14019146 chr3:50243930 SLC38A3 0.36 8.26 0.41 3.53e-15 Body mass index; LUSC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -9.92 -0.48 1.68e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs17095355 0.818 rs11194981 chr10:111861054 A/G cg00817464 chr10:111662876 XPNPEP1 -0.51 -6.56 -0.34 2.1e-10 Biliary atresia; LUSC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg23791538 chr6:167370224 RNASET2 -0.37 -5.69 -0.3 2.82e-8 Crohn's disease; LUSC cis rs7903847 0.642 rs11189206 chr10:99167802 T/C cg08345082 chr10:99160200 RRP12 -0.35 -7.27 -0.37 2.51e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs9467711 0.559 rs12176129 chr6:26514940 C/T cg09904177 chr6:26538194 HMGN4 -0.71 -6.58 -0.34 1.79e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4285028 0.948 rs12493952 chr3:121708497 C/T cg11130432 chr3:121712080 ILDR1 -0.65 -10.09 -0.48 4.39e-21 Multiple sclerosis; LUSC cis rs7677751 0.806 rs7698425 chr4:55090656 C/T cg17187183 chr4:55093834 PDGFRA 0.38 5.83 0.3 1.3e-8 Corneal astigmatism; LUSC cis rs7605827 0.930 rs13398393 chr2:15602804 T/G cg19274914 chr2:15703543 NA 0.46 9.04 0.44 1.27e-17 Educational attainment (years of education); LUSC cis rs7524258 0.868 rs4908451 chr1:7299618 C/G cg07173049 chr1:7289937 CAMTA1 -0.31 -6.54 -0.34 2.35e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs9527 0.641 rs34130454 chr10:104903638 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs9733 0.687 rs11204735 chr1:150841667 T/C cg04414720 chr1:150670196 GOLPH3L -0.45 -6.97 -0.36 1.75e-11 Tonsillectomy; LUSC cis rs9311676 0.632 rs62259780 chr3:58428078 T/G cg26110898 chr3:58419937 PDHB 0.4 6.53 0.34 2.51e-10 Systemic lupus erythematosus; LUSC cis rs2439831 0.867 rs2412778 chr15:43660982 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 6.45 0.33 3.91e-10 Personality dimensions; LUSC cis rs79911532 0.515 rs114616297 chr7:75719576 T/G cg03592824 chr7:75666768 STYXL1 0.67 6.41 0.33 4.98e-10 Mononucleosis; LUSC cis rs9517320 1.000 rs12864890 chr13:99126457 T/C cg20487152 chr13:99095054 FARP1 0.36 6.71 0.34 8.35e-11 Longevity; LUSC trans rs853679 1.000 rs1936365 chr6:28268452 C/G cg06606381 chr12:133084897 FBRSL1 0.52 6.31 0.33 8.98e-10 Depression; LUSC cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg14196790 chr5:131705035 SLC22A5 0.52 8.9 0.44 3.57e-17 Blood metabolite levels; LUSC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg08048268 chr3:133502702 NA -0.46 -8.84 -0.44 5.49e-17 Iron status biomarkers; LUSC cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg02380750 chr20:61661411 NA 0.35 5.94 0.31 7e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4363385 0.747 rs4478766 chr1:152984906 G/A cg00922841 chr1:152955080 SPRR1A -0.45 -7.84 -0.39 6.12e-14 Inflammatory skin disease; LUSC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg04362960 chr10:104952993 NT5C2 0.57 8.98 0.44 2.02e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg08773314 chr2:239334832 ASB1 0.41 8.83 0.44 5.99e-17 Multiple system atrophy; LUSC cis rs4969178 0.965 rs2292643 chr17:76395421 G/A cg05887092 chr17:76393375 PGS1 0.54 9.77 0.47 5.57e-20 HDL cholesterol levels; LUSC cis rs9329221 0.905 rs13254263 chr8:10255181 A/G cg21775007 chr8:11205619 TDH -0.57 -8.39 -0.42 1.4e-15 Neuroticism; LUSC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg24399712 chr22:39784796 NA -0.65 -12.03 -0.55 6.31e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2439831 0.850 rs28524541 chr15:44124831 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.74 0.35 7.17e-11 Lung cancer in ever smokers; LUSC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg01448562 chr3:133502909 NA -0.66 -10.75 -0.51 2.4e-23 Iron status biomarkers; LUSC trans rs7937682 0.924 rs513425 chr11:111504861 C/T cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg06637938 chr14:75390232 RPS6KL1 0.53 8.42 0.42 1.13e-15 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10735116 chr1:147400532 GPR89B 0.47 6.41 0.33 5.1e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg18758796 chr5:131593413 PDLIM4 0.43 7.26 0.37 2.68e-12 Breast cancer; LUSC cis rs11971779 0.715 rs10265 chr7:139026152 T/G cg07862535 chr7:139043722 LUC7L2 0.53 6.61 0.34 1.54e-10 Diisocyanate-induced asthma; LUSC cis rs4363385 0.510 rs6664380 chr1:153030365 G/T cg25856811 chr1:152973957 SPRR3 -0.39 -6.35 -0.33 6.83e-10 Inflammatory skin disease; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.2 -0.32 1.71e-9 Coronary artery disease; LUSC cis rs1018836 0.608 rs6992512 chr8:91477936 C/A cg16814680 chr8:91681699 NA -0.56 -8.3 -0.41 2.68e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs17828380 0.920 rs71394506 chr15:63601026 A/T cg05507819 chr15:63340323 TPM1 -0.75 -6.13 -0.32 2.5e-9 Social communication problems; LUSC cis rs9549260 0.640 rs4943796 chr13:41196016 C/T cg21288729 chr13:41239152 FOXO1 0.6 9.19 0.45 4.44e-18 Red blood cell count; LUSC cis rs9611519 1.000 rs9611505 chr22:41540279 T/C cg13813247 chr22:41461852 NA -0.37 -6.76 -0.35 6.12e-11 Neuroticism; LUSC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg02574844 chr11:5959923 NA -0.44 -6.31 -0.33 8.96e-10 DNA methylation (variation); LUSC cis rs2219968 0.923 rs7822053 chr8:78979111 A/G cg00738934 chr8:78996279 NA 0.38 6.91 0.35 2.52e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg06637938 chr14:75390232 RPS6KL1 -0.47 -7.4 -0.38 1.08e-12 Height; LUSC cis rs2798269 0.604 rs6490662 chr13:22153280 A/G cg18095732 chr13:22033692 ZDHHC20 -0.48 -7.69 -0.39 1.63e-13 PR segment; LUSC cis rs2075165 0.836 rs7512751 chr1:156234439 T/G cg20302342 chr1:156215951 PAQR6 0.31 5.99 0.31 5.41e-9 Tonsillectomy; LUSC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg09796270 chr17:17721594 SREBF1 0.42 7.49 0.38 6.2e-13 Total body bone mineral density; LUSC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.11 -0.32 2.77e-9 Major depressive disorder; LUSC cis rs826838 0.834 rs826874 chr12:39122599 C/A cg26384229 chr12:38710491 ALG10B -0.77 -13.56 -0.6 1.11e-33 Heart rate; LUSC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.54e-21 Electroencephalogram traits; LUSC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg05729581 chr11:3078854 CARS -0.5 -7.25 -0.37 2.98e-12 Longevity; LUSC cis rs3806843 0.735 rs813897 chr5:140070029 T/C cg26395211 chr5:140044315 WDR55 0.45 6.99 0.36 1.5e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg03146154 chr1:46216737 IPP 0.55 8.21 0.41 5.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs977987 0.806 rs4888405 chr16:75428196 A/C cg03315344 chr16:75512273 CHST6 0.48 9.03 0.44 1.41e-17 Dupuytren's disease; LUSC cis rs17155006 0.664 rs411396 chr7:107744759 A/G cg05962710 chr7:107745446 LAMB4 -0.34 -6.16 -0.32 2.08e-9 Pneumococcal bacteremia; LUSC cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC trans rs2562456 0.833 rs2928211 chr19:21541297 A/G cg00806126 chr19:22604979 ZNF98 0.39 5.98 0.31 5.68e-9 Pain; LUSC cis rs7903847 0.642 rs11189196 chr10:99155079 A/G cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs17270561 0.723 rs12213243 chr6:25890108 C/T cg17042849 chr6:26104293 HIST1H4C -0.48 -5.9 -0.31 8.94e-9 Iron status biomarkers; LUSC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg06238570 chr21:40685208 BRWD1 0.47 7.25 0.37 2.84e-12 Cognitive function; LUSC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg08859206 chr1:53392774 SCP2 0.52 8.93 0.44 2.96e-17 Monocyte count; LUSC cis rs7647973 1.000 rs62259944 chr3:49430883 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.48 -7.07 -0.36 9.08e-12 Menarche (age at onset); LUSC cis rs6752107 0.967 rs3792111 chr2:234179690 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.73 12.24 0.56 1.02e-28 Crohn's disease;Inflammatory bowel disease; LUSC trans rs7613875 0.600 rs2856238 chr3:50158191 C/T cg21659725 chr3:3221576 CRBN 0.52 8.01 0.4 1.88e-14 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14787155 chr3:108308533 DZIP3;KIAA1524 0.4 6.57 0.34 1.93e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.31 0.37 1.99e-12 Motion sickness; LUSC cis rs7605827 0.930 rs4668903 chr2:15530051 C/G cg19274914 chr2:15703543 NA 0.47 9.08 0.44 1e-17 Educational attainment (years of education); LUSC cis rs4253772 0.872 rs14843 chr22:46639462 A/T cg09491104 chr22:46646882 C22orf40 -0.63 -6.52 -0.34 2.57e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.69e-9 Systolic blood pressure; LUSC trans rs637571 0.565 rs570387 chr11:65637076 T/C cg17712092 chr4:129076599 LARP1B -0.83 -12.42 -0.56 2.18e-29 Eosinophil percentage of white cells; LUSC cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg08999081 chr20:33150536 PIGU 0.52 10.44 0.5 2.89e-22 Glomerular filtration rate (creatinine); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12103840 chr6:108582260 SNX3 -0.42 -6.22 -0.32 1.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs459571 0.876 rs2520095 chr9:136919568 A/G cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.43 -6.22 -0.32 1.47e-9 Platelet distribution width; LUSC cis rs11583043 0.958 rs12746722 chr1:101464789 G/T cg11406453 chr1:101602562 NA -0.33 -5.68 -0.3 2.9e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg13114125 chr14:105738426 BRF1 -0.92 -16.03 -0.66 2.78e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg23649088 chr2:200775458 C2orf69 0.54 7.25 0.37 2.86e-12 Schizophrenia; LUSC trans rs1814175 0.765 rs11493326 chr11:50018063 T/C cg03929089 chr4:120376271 NA -1.02 -19.53 -0.73 3.23e-57 Height; LUSC cis rs6484504 0.532 rs1475558 chr11:31263428 A/G cg26647111 chr11:31128758 NA -0.41 -5.9 -0.31 9e-9 Red blood cell count; LUSC cis rs3892630 0.878 rs8112955 chr19:33191192 C/T cg22980127 chr19:33182716 NUDT19 0.94 12.81 0.57 7.79e-31 Red blood cell traits; LUSC cis rs11792861 0.926 rs72607172 chr9:111876523 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.49 0.42 7.11e-16 Menarche (age at onset); LUSC cis rs10489525 0.599 rs11102879 chr1:115603504 C/T cg17147537 chr1:115611705 TSPAN2 0.3 6.04 0.31 4.11e-9 Autism; LUSC cis rs2617583 0.904 rs2937639 chr5:1443728 A/G cg07148919 chr5:1466943 LPCAT1 0.44 6.8 0.35 4.81e-11 Breast cancer; LUSC cis rs40363 0.951 rs72778117 chr16:3531827 T/C cg05754148 chr16:3507555 NAT15 0.8 9.5 0.46 4.08e-19 Tuberculosis; LUSC cis rs77633900 0.772 rs2469224 chr15:76651327 T/G cg21673338 chr15:77095150 SCAPER -0.72 -6.26 -0.32 1.21e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs7107174 0.892 rs2512519 chr11:77953015 C/T cg02023728 chr11:77925099 USP35 0.51 7.18 0.37 4.62e-12 Testicular germ cell tumor; LUSC cis rs2996428 0.667 rs2368534 chr1:3740640 C/T cg23277830 chr1:3704460 LRRC47 0.36 6.7 0.34 8.7e-11 Red cell distribution width; LUSC trans rs7819412 0.936 rs7814499 chr8:11040647 A/G cg08975724 chr8:8085496 FLJ10661 -0.46 -6.44 -0.33 4.07e-10 Triglycerides; LUSC cis rs12122100 0.526 rs12122534 chr1:146504399 A/G cg02487331 chr1:146550467 NA 0.44 7.5 0.38 5.75e-13 HIV-1 control; LUSC cis rs4820539 0.966 rs2283803 chr22:23454881 G/A cg14186256 chr22:23484241 RTDR1 0.96 17.8 0.7 2.65e-50 Bone mineral density; LUSC cis rs9311676 0.632 rs6777066 chr3:58361603 T/C cg13750441 chr3:58318267 PXK 0.34 6.66 0.34 1.1e-10 Systemic lupus erythematosus; LUSC cis rs34638657 0.827 rs11641736 chr16:82206279 G/A cg09439754 chr16:82129088 HSD17B2 -0.38 -5.83 -0.3 1.34e-8 Lung adenocarcinoma; LUSC cis rs7192380 1.000 rs11647110 chr16:69589363 G/A cg26679644 chr16:69762563 NA 0.32 5.71 0.3 2.46e-8 Sjögren's syndrome; LUSC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.72 -0.39 1.35e-13 Lymphocyte counts; LUSC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg13126279 chr21:47581558 C21orf56 0.41 5.8 0.3 1.57e-8 Testicular germ cell tumor; LUSC cis rs79976124 0.879 rs12214239 chr6:66636059 A/G cg07460842 chr6:66804631 NA 0.71 8.87 0.44 4.61e-17 Type 2 diabetes; LUSC cis rs208515 0.525 rs12204706 chr6:66669930 A/G cg07460842 chr6:66804631 NA -1.05 -14.12 -0.61 7.94e-36 Exhaled nitric oxide levels; LUSC cis rs2688608 0.592 rs13013 chr10:75562161 C/A cg17411546 chr10:75410026 SYNPO2L -0.53 -7.83 -0.39 6.71e-14 Inflammatory bowel disease; LUSC cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg24060327 chr5:131705240 SLC22A5 0.48 8.18 0.41 5.94e-15 Blood metabolite levels; LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg10802521 chr3:52805072 NEK4 0.54 8.38 0.42 1.45e-15 Bipolar disorder; LUSC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11890956 chr21:40555474 PSMG1 -0.85 -15.04 -0.64 2.21e-39 Cognitive function; LUSC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg20406979 chr6:167373233 NA 0.26 6.0 0.31 5.2e-9 Crohn's disease; LUSC cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg03146154 chr1:46216737 IPP 0.52 7.57 0.38 3.58e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2839186 0.867 rs13050387 chr21:47701423 C/T cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.06e-9 Testicular germ cell tumor; LUSC cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.42 0.64 7.15e-41 Bladder cancer; LUSC trans rs9929218 1.000 rs9937664 chr16:68784603 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -12.33 -0.56 4.85e-29 Colorectal cancer; LUSC cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg06552810 chr11:31128660 NA -0.4 -7.08 -0.36 8.78e-12 Red blood cell count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26080111 chr7:559651 PDGFA 0.51 6.95 0.36 1.98e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2439831 0.850 rs558656 chr15:43723514 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.03 0.44 1.37e-17 Lung cancer in ever smokers; LUSC cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg05347473 chr6:146136440 FBXO30 0.49 8.22 0.41 4.64e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2658782 0.507 rs4457713 chr11:93037430 C/T cg15737290 chr11:93063684 CCDC67 0.9 13.88 0.6 6.67e-35 Pulmonary function decline; LUSC cis rs2298450 0.555 rs2845756 chr21:37611892 A/G cg02919814 chr21:37666008 DOPEY2 -0.42 -6.26 -0.32 1.15e-9 Schizophrenia; LUSC trans rs1728785 1.000 rs1645936 chr16:68563743 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.54 7.08 0.36 8.34e-12 Ulcerative colitis; LUSC cis rs73198271 0.603 rs571130 chr8:8593691 A/G cg01851573 chr8:8652454 MFHAS1 0.4 6.22 0.32 1.52e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg06028605 chr16:24865363 SLC5A11 0.66 9.6 0.46 2.02e-19 Intelligence (multi-trait analysis); LUSC cis rs71403859 0.502 rs34015581 chr16:71508229 T/A cg08717414 chr16:71523259 ZNF19 -0.64 -7.54 -0.38 4.54e-13 Post bronchodilator FEV1; LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs10100465 0.961 rs1813506 chr8:118648439 A/G cg09430518 chr8:118662568 NA -0.29 -5.66 -0.3 3.31e-8 Leprosy; LUSC trans rs7647973 0.626 rs7637711 chr3:49829653 A/G cg21659725 chr3:3221576 CRBN 0.67 8.07 0.4 1.29e-14 Menarche (age at onset); LUSC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg14004847 chr7:1930337 MAD1L1 -0.59 -8.99 -0.44 1.83e-17 Schizophrenia; LUSC trans rs6951245 0.529 rs10262070 chr7:1141738 C/T cg13565492 chr6:43139072 SRF -0.73 -10.88 -0.51 8.22e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.54 0.46 3.1400000000000002e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg05347473 chr6:146136440 FBXO30 0.58 10.1 0.48 4.28e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs8017423 0.615 rs12586761 chr14:90820897 A/G cg04374321 chr14:90722782 PSMC1 -0.44 -6.63 -0.34 1.34e-10 Mortality in heart failure; LUSC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg06618935 chr21:46677482 NA -0.42 -8.56 -0.42 4.14e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs554111 0.656 rs10799680 chr1:21361181 C/T cg01072550 chr1:21505969 NA 0.4 6.08 0.32 3.33e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs12586317 0.620 rs28404080 chr14:35539418 G/T cg16230307 chr14:35515116 FAM177A1 0.78 10.01 0.48 8.33e-21 Psoriasis; LUSC cis rs11758351 1.000 rs16891401 chr6:26202337 G/A cg01420254 chr6:26195488 NA 0.71 7.44 0.38 8.44e-13 Gout;Renal underexcretion gout; LUSC cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.35 0.33 7.1e-10 Intelligence (multi-trait analysis); LUSC cis rs2072499 0.966 rs2853643 chr1:156184831 G/A cg25208724 chr1:156163844 SLC25A44 1.08 22.65 0.78 1.77e-69 Testicular germ cell tumor; LUSC cis rs611744 0.669 rs13251024 chr8:109258333 T/C cg21045802 chr8:109455806 TTC35 0.43 6.57 0.34 1.92e-10 Dupuytren's disease; LUSC cis rs6582630 0.621 rs10880656 chr12:38571220 A/C cg26384229 chr12:38710491 ALG10B -0.53 -7.83 -0.39 6.36e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs6469656 0.730 rs1317271 chr8:117682668 T/A cg24004040 chr8:117650383 NA -0.43 -6.31 -0.33 9.04e-10 Colorectal cancer; LUSC cis rs55665837 1.000 rs12288873 chr11:14450465 C/T cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs6967385 0.902 rs10282726 chr7:12372911 A/C cg06484146 chr7:12443880 VWDE 0.39 5.8 0.3 1.51e-8 Response to taxane treatment (placlitaxel); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14515252 chr20:5093771 C20orf30 0.7 6.1 0.32 2.9e-9 Cognitive performance; LUSC cis rs9814567 1.000 rs2370641 chr3:134222161 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.79 -0.6 1.45e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs861020 0.582 rs630065 chr1:209998662 C/T cg05527609 chr1:210001259 C1orf107 0.66 9.4 0.46 9.25e-19 Orofacial clefts; LUSC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.23e-12 Blood metabolite levels; LUSC cis rs709400 0.663 rs7158822 chr14:103887868 C/T cg12935359 chr14:103987150 CKB -0.52 -7.94 -0.4 3.04e-14 Body mass index; LUSC cis rs9527 0.615 rs10883781 chr10:104581130 A/G cg04362960 chr10:104952993 NT5C2 0.69 9.95 0.48 1.29e-20 Arsenic metabolism; LUSC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg02951883 chr7:2050386 MAD1L1 -0.56 -10.39 -0.49 4.28e-22 Bipolar disorder and schizophrenia; LUSC cis rs477692 1.000 rs7475154 chr10:131440584 C/T cg26102564 chr10:131424627 MGMT -0.39 -6.07 -0.31 3.57e-9 Response to temozolomide; LUSC trans rs12188164 0.931 rs115554641 chr5:443236 C/G cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg24562669 chr7:97807699 LMTK2 0.42 7.16 0.36 5.09e-12 Breast cancer; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.44 0.53 8.75e-26 Prudent dietary pattern; LUSC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg12560992 chr17:57184187 TRIM37 -0.89 -17.41 -0.69 8.89e-49 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.79e-30 Prudent dietary pattern; LUSC cis rs1372520 0.684 rs2619341 chr4:90741773 A/G cg01966878 chr4:90757139 SNCA -0.41 -5.82 -0.3 1.38e-8 Neuroticism; LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg05368731 chr17:41323189 NBR1 0.95 16.43 0.67 7.01e-45 Menopause (age at onset); LUSC cis rs4523957 0.928 rs11657644 chr17:2175210 C/G cg16513277 chr17:2031491 SMG6 -0.57 -9.57 -0.46 2.56e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg13012494 chr21:47604986 C21orf56 0.42 5.78 0.3 1.73e-8 Testicular germ cell tumor; LUSC cis rs936229 0.651 rs12908814 chr15:75132490 C/G cg14664628 chr15:75095509 CSK -0.74 -11.9 -0.55 1.85e-27 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg16520312 chr17:43971471 MAPT;LOC100128977 0.38 6.48 0.33 3.33e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg08859206 chr1:53392774 SCP2 -0.42 -6.86 -0.35 3.42e-11 Monocyte count; LUSC cis rs208520 0.690 rs3899423 chr6:66835285 A/G cg07460842 chr6:66804631 NA -1.1 -17.51 -0.69 3.81e-49 Exhaled nitric oxide output; LUSC cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg26384229 chr12:38710491 ALG10B 0.87 15.08 0.64 1.52e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs9611565 0.592 rs5996039 chr22:41981957 A/G cg03806693 chr22:41940476 POLR3H -0.91 -12.72 -0.57 1.7e-30 Vitiligo; LUSC trans rs2262909 0.962 rs12610034 chr19:22314528 G/A cg17074339 chr11:11642133 GALNTL4 0.43 6.51 0.34 2.69e-10 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7523050 0.730 rs72984612 chr1:109434826 T/C cg08274380 chr1:109419600 GPSM2 1.13 11.51 0.53 4.76e-26 Fat distribution (HIV); LUSC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg27539214 chr16:67997921 SLC12A4 -0.51 -7.6 -0.38 3.02e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.08 -0.4 1.22e-14 Axial length; LUSC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg00033643 chr7:134001901 SLC35B4 0.45 7.05 0.36 1.02e-11 Mean platelet volume; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg03188948 chr7:1209495 NA 0.66 7.09 0.36 8.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg20243544 chr17:37824526 PNMT 0.39 5.96 0.31 6.31e-9 Self-reported allergy; LUSC cis rs131777 0.575 rs963980 chr22:51022117 C/A cg25575065 chr22:51066394 ARSA -0.43 -6.03 -0.31 4.33e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.05 21.67 0.76 1.2e-65 Height; LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 2.93e-34 Prudent dietary pattern; LUSC cis rs28595532 0.557 rs12498329 chr4:119311524 C/T cg21605333 chr4:119757512 SEC24D 0.55 6.31 0.33 8.75e-10 Cannabis dependence symptom count; LUSC cis rs2414856 0.510 rs72758931 chr15:64661224 T/C cg08069370 chr15:64387884 SNX1 -0.78 -6.58 -0.34 1.84e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.13e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7119 0.717 rs12911963 chr15:77807175 G/C cg27398640 chr15:77910606 LINGO1 -0.29 -6.1 -0.32 2.93e-9 Type 2 diabetes; LUSC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21659725 chr3:3221576 CRBN -0.88 -18.04 -0.7 2.88e-51 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.63 0.5 6.24e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs7584330 0.554 rs75918156 chr2:238426287 G/A cg16989719 chr2:238392110 NA -0.44 -6.3 -0.33 9.5e-10 Prostate cancer; LUSC trans rs208520 0.754 rs851593 chr6:66875783 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.09 16.59 0.67 1.66e-45 Exhaled nitric oxide output; LUSC cis rs977987 0.902 rs34539062 chr16:75493279 C/A cg03315344 chr16:75512273 CHST6 0.53 9.97 0.48 1.13e-20 Dupuytren's disease; LUSC cis rs920590 0.573 rs6986456 chr8:19680562 A/G cg03894339 chr8:19674705 INTS10 0.44 6.14 0.32 2.37e-9 Acute lymphoblastic leukemia (childhood); LUSC trans rs7937682 0.883 rs472465 chr11:111468962 C/T cg18187862 chr3:45730750 SACM1L 0.53 6.78 0.35 5.31e-11 Primary sclerosing cholangitis; LUSC cis rs10489525 0.599 rs7516121 chr1:115604317 A/G cg17147537 chr1:115611705 TSPAN2 0.3 6.04 0.31 4.11e-9 Autism; LUSC cis rs9796 0.870 rs28581803 chr15:41326513 G/A cg18705301 chr15:41695430 NDUFAF1 -0.41 -7.08 -0.36 8.46e-12 Menopause (age at onset); LUSC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 16.82 0.68 2.06e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2286885 1.000 rs2277159 chr9:129243383 C/T cg15282417 chr9:129245246 FAM125B 0.36 6.0 0.31 5.25e-9 Intraocular pressure; LUSC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11644478 chr21:40555479 PSMG1 -0.6 -9.28 -0.45 2.25e-18 Menarche (age at onset); LUSC cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2274273 0.805 rs7159808 chr14:55624327 G/T cg04306507 chr14:55594613 LGALS3 0.58 13.67 0.6 4.23e-34 Protein biomarker; LUSC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs865483 0.895 rs72828253 chr17:35783416 A/G cg06716730 chr17:35851459 DUSP14 -0.26 -5.73 -0.3 2.2e-8 Monocyte count; LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC trans rs1908814 0.516 rs10113062 chr8:11793249 A/G cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.64e-16 Neuroticism; LUSC cis rs7945718 0.935 rs4757059 chr11:12812356 G/A cg25843174 chr11:12811716 TEAD1 -0.33 -7.45 -0.38 7.84e-13 Educational attainment (years of education); LUSC cis rs9467773 0.620 rs2494701 chr6:26634432 C/T cg09904177 chr6:26538194 HMGN4 0.65 11.7 0.54 9.83e-27 Intelligence (multi-trait analysis); LUSC trans rs10221833 0.602 rs355879 chr2:165633427 T/C cg26993132 chr16:89239499 CDH15 0.31 5.97 0.31 6.09e-9 Response to statin therapy; LUSC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.23e-10 Extrinsic epigenetic age acceleration; LUSC cis rs17270561 0.609 rs4464787 chr6:25733558 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.56 0.38 3.9e-13 Iron status biomarkers; LUSC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC cis rs34375054 0.525 rs12316499 chr12:125593318 G/A cg00522288 chr12:125625016 AACS -0.32 -6.12 -0.32 2.67e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs11971779 0.680 rs10085901 chr7:139108989 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg24648061 chr7:107114615 COG5;GPR22 -0.37 -6.0 -0.31 5.05e-9 Calcium levels; LUSC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg16049864 chr8:95962084 TP53INP1 -0.68 -13.32 -0.59 9.66e-33 Type 2 diabetes; LUSC cis rs6977660 1.000 rs10275322 chr7:19821220 C/T cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs10875746 0.951 rs2286021 chr12:48528220 C/T cg13454099 chr12:49076203 C12orf41 -0.52 -6.15 -0.32 2.27e-9 Longevity (90 years and older); LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.82 -0.35 4.26e-11 Bipolar disorder and schizophrenia; LUSC cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.82 0.3 1.34e-8 Rheumatoid arthritis; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg21782813 chr7:2030301 MAD1L1 0.35 5.8 0.3 1.56e-8 Bipolar disorder and schizophrenia; LUSC cis rs79149102 0.579 rs58645417 chr15:75325858 T/G cg17294928 chr15:75287854 SCAMP5 -0.71 -6.4 -0.33 5.27e-10 Lung cancer; LUSC cis rs6545883 0.929 rs2463100 chr2:61659199 C/G cg15711740 chr2:61764176 XPO1 -0.46 -7.02 -0.36 1.27e-11 Tuberculosis; LUSC cis rs2377585 0.653 rs10505735 chr12:8841741 A/G cg03761649 chr12:8850719 RIMKLB 0.45 5.68 0.3 2.89e-8 Reticulocyte fraction of red cells; LUSC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg06808227 chr14:105710500 BRF1 0.66 10.41 0.5 3.54e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs8114671 0.967 rs6060285 chr20:33770487 G/T cg07148914 chr20:33460835 GGT7 0.47 6.95 0.36 1.92e-11 Height; LUSC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg17366294 chr4:99064904 C4orf37 0.6 10.58 0.5 9.38e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg25019033 chr10:957182 NA -0.5 -6.2 -0.32 1.69e-9 Eosinophil percentage of granulocytes; LUSC cis rs10979 0.597 rs9321927 chr6:143913295 A/G cg25407410 chr6:143891975 LOC285740 0.57 7.4 0.38 1.1e-12 Hypospadias; LUSC trans rs7937682 1.000 rs7937682 chr11:111579939 C/G cg18187862 chr3:45730750 SACM1L 0.54 6.78 0.35 5.48e-11 Primary sclerosing cholangitis; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg27555525 chr19:5237619 PTPRS -0.39 -6.34 -0.33 7.24e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs12594515 1.000 rs11070464 chr15:45984776 C/A cg01629716 chr15:45996671 NA 0.4 5.95 0.31 6.66e-9 Waist circumference;Weight; LUSC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg01448562 chr3:133502909 NA -0.61 -9.8 -0.47 4.38e-20 Iron status biomarkers; LUSC cis rs4478858 0.735 rs10914360 chr1:31817476 G/A cg00250761 chr1:31883323 NA -0.37 -9.16 -0.45 5.22e-18 Alcohol dependence; LUSC cis rs1670533 0.585 rs6827206 chr4:1065071 A/T cg02018176 chr4:1364513 KIAA1530 0.43 6.12 0.32 2.58e-9 Recombination rate (females); LUSC cis rs8099014 1.000 rs2002088 chr18:56132725 G/A cg12907477 chr18:56117327 MIR122 0.44 6.84 0.35 3.77e-11 Platelet count; LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg07507251 chr3:52567010 NT5DC2 0.29 5.68 0.3 2.96e-8 Bipolar disorder; LUSC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 6.46 0.33 3.77e-10 Electroencephalogram traits; LUSC trans rs629535 0.767 rs72654073 chr8:70081231 G/A cg21567404 chr3:27674614 NA -0.98 -15.73 -0.65 4.01e-42 Dupuytren's disease; LUSC trans rs11088226 0.681 rs2833891 chr21:33928821 A/G cg09050820 chr6:167586206 TCP10L2 0.73 10.12 0.48 3.48e-21 Gastritis; LUSC cis rs8062405 0.965 rs8049439 chr16:28837515 A/G cg05966235 chr16:28915196 ATP2A1 0.34 6.23 0.32 1.43e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs3733585 0.699 rs7677710 chr4:9969517 T/G cg26043149 chr18:55253948 FECH -0.46 -7.11 -0.36 7.02e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg05283184 chr6:79620031 NA -0.58 -11.98 -0.55 9.08e-28 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg10755058 chr3:40428713 ENTPD3 0.34 5.86 0.31 1.12e-8 Renal cell carcinoma; LUSC cis rs921665 0.831 rs4497900 chr2:3190754 A/G cg16434511 chr2:3151078 NA -0.63 -6.82 -0.35 4.22e-11 World class endurance athleticism; LUSC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg26677194 chr12:130822605 PIWIL1 0.6 8.97 0.44 2.17e-17 Menopause (age at onset); LUSC cis rs7607369 0.596 rs10165754 chr2:219287370 A/G cg02176678 chr2:219576539 TTLL4 -0.71 -11.63 -0.54 1.7e-26 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs8114671 0.805 rs6060168 chr20:33621017 C/T cg24642439 chr20:33292090 TP53INP2 0.43 6.18 0.32 1.82e-9 Height; LUSC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg14668632 chr7:2872130 GNA12 -0.43 -6.5 -0.34 2.85e-10 Height; LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg08736216 chr1:53307985 ZYG11A 0.3 6.19 0.32 1.73e-9 Monocyte count; LUSC cis rs9314323 0.798 rs12682345 chr8:26218332 A/G cg13160058 chr8:26243215 BNIP3L 0.38 6.83 0.35 3.93e-11 Red cell distribution width; LUSC cis rs7267979 1.000 rs6050617 chr20:25421648 C/T cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1577917 1.000 rs10455456 chr6:86670322 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.64 -0.34 1.26e-10 Response to antipsychotic treatment; LUSC cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg17892150 chr10:133769511 PPP2R2D -0.64 -8.66 -0.43 1.99e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs7819412 0.745 rs4841498 chr8:10985432 C/T cg15556689 chr8:8085844 FLJ10661 -0.43 -6.42 -0.33 4.8e-10 Triglycerides; LUSC trans rs4729127 1.000 rs4729125 chr7:93997093 C/G cg20086523 chr13:52378287 DHRS12 0.59 6.48 0.33 3.37e-10 Intelligence; LUSC cis rs2806561 0.765 rs2806557 chr1:23503372 T/A cg19743168 chr1:23544995 NA 0.43 8.19 0.41 5.49e-15 Height; LUSC cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg26384229 chr12:38710491 ALG10B 0.93 17.54 0.69 2.66e-49 Heart rate; LUSC cis rs599083 0.573 rs3018713 chr11:68390986 A/G cg01657329 chr11:68192670 LRP5 -0.5 -7.92 -0.4 3.45e-14 Bone mineral density (spine); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04357272 chr7:102312308 POLR2J2 -0.46 -6.55 -0.34 2.23e-10 Electrocardiographic conduction measures; LUSC cis rs12711979 0.765 rs881852 chr2:3821508 A/G cg17052675 chr2:3827356 NA -0.56 -10.88 -0.51 8.15e-24 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs72634258 0.945 rs12757968 chr1:8106201 A/G cg00042356 chr1:8021962 PARK7 0.84 10.02 0.48 8.04e-21 Inflammatory bowel disease; LUSC cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg22906224 chr7:99728672 NA 0.53 7.77 0.39 1e-13 Coronary artery disease; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg12484037 chr17:68165632 KCNJ2 0.4 5.99 0.31 5.49e-9 Metabolite levels (Pyroglutamine); LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg06145435 chr7:1022769 CYP2W1 0.31 6.67 0.34 1.09e-10 Longevity;Endometriosis; LUSC trans rs10506458 0.915 rs17738485 chr12:63394932 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -15.44 -0.65 5.73e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg22166914 chr1:53195759 ZYG11B 0.6 10.15 0.49 2.86e-21 Monocyte count; LUSC cis rs9393692 0.645 rs4145910 chr6:26313305 T/C cg00631329 chr6:26305371 NA -0.55 -10.61 -0.5 7.6e-23 Educational attainment; LUSC cis rs4363385 0.510 rs6664380 chr1:153030365 G/T cg00922841 chr1:152955080 SPRR1A -0.37 -6.15 -0.32 2.26e-9 Inflammatory skin disease; LUSC cis rs1957429 0.901 rs6573583 chr14:65351211 G/T cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs11217036 1 rs11217036 chr11:118675772 C/T cg19308663 chr11:118741387 NA 0.36 6.47 0.33 3.49e-10 Allergy; LUSC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.72 -6.72 -0.35 7.85e-11 Cerebrospinal P-tau181p levels; LUSC cis rs3820928 0.874 rs4234066 chr2:227882180 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.8 -0.39 7.97e-14 Pulmonary function; LUSC cis rs4919694 1.000 rs74749600 chr10:104732996 T/C cg05855489 chr10:104503620 C10orf26 0.57 5.64 0.3 3.57e-8 Arsenic metabolism; LUSC cis rs1595825 0.891 rs73056823 chr2:198769788 T/C cg00982548 chr2:198649783 BOLL -0.56 -7.0 -0.36 1.41e-11 Ulcerative colitis; LUSC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.42 6.2 0.32 1.71e-9 Systemic lupus erythematosus; LUSC cis rs9788682 0.747 rs7183604 chr15:78899213 T/C cg06917634 chr15:78832804 PSMA4 0.51 6.49 0.33 3.03e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2235642 0.653 rs7197288 chr16:1654753 C/A cg26528668 chr16:1614120 IFT140 0.44 7.19 0.37 4.24e-12 Coronary artery disease; LUSC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.78 -9.45 -0.46 6.16e-19 Mean platelet volume; LUSC trans rs3749237 0.964 rs2234385 chr3:49846041 G/A cg21659725 chr3:3221576 CRBN 0.6 8.77 0.43 9.54e-17 Resting heart rate; LUSC cis rs3771570 0.901 rs35496488 chr2:242434316 G/A cg21155796 chr2:242212141 HDLBP 0.62 6.84 0.35 3.68e-11 Prostate cancer; LUSC cis rs7197653 0.748 rs8060690 chr16:68340085 G/T cg09835421 chr16:68378352 PRMT7 -0.78 -8.02 -0.4 1.79e-14 Magnesium levels; LUSC cis rs4343996 0.967 rs4588749 chr7:3363992 A/G cg21248987 chr7:3385318 SDK1 -0.39 -6.54 -0.34 2.3e-10 Motion sickness; LUSC cis rs6580649 0.941 rs7971668 chr12:48469696 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs7582720 0.945 rs2351524 chr2:203880992 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.76 -8.34 -0.42 1.98e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs826838 0.651 rs1843892 chr12:38616965 A/G cg13010199 chr12:38710504 ALG10B 0.59 8.84 0.44 5.46e-17 Heart rate; LUSC cis rs6987853 0.901 rs2923429 chr8:42389743 A/G cg09913449 chr8:42400586 C8orf40 0.5 8.32 0.41 2.25e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg21951975 chr1:209979733 IRF6 0.62 8.06 0.4 1.4e-14 Cleft lip with or without cleft palate; LUSC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg26597838 chr10:835615 NA 0.99 13.83 0.6 1.05e-34 Eosinophil percentage of granulocytes; LUSC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9325144 0.647 rs61931899 chr12:38892422 A/G cg26384229 chr12:38710491 ALG10B -0.6 -9.09 -0.45 8.85e-18 Morning vs. evening chronotype; LUSC cis rs2290416 0.792 rs62522167 chr8:144678034 G/A cg26536354 chr8:144654954 C8orf73 0.67 7.31 0.37 2.05e-12 Attention deficit hyperactivity disorder; LUSC cis rs7804356 1.000 rs3934268 chr7:26890572 G/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg04518342 chr5:131593106 PDLIM4 0.36 6.72 0.35 7.84e-11 Blood metabolite levels; LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.86 0.31 1.13e-8 Menopause (age at onset); LUSC cis rs7582180 0.663 rs1114595 chr2:100960072 T/A cg12002119 chr2:101014098 CHST10 0.35 5.85 0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.61 0.43 2.85e-16 Alzheimer's disease; LUSC cis rs13082711 0.911 rs13078798 chr3:27445971 A/G cg02860705 chr3:27208620 NA -0.5 -8.65 -0.43 2.21e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4803468 1.000 rs10422783 chr19:41906436 T/C cg09537434 chr19:41945824 ATP5SL -0.89 -15.78 -0.65 2.66e-42 Height; LUSC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg21028142 chr17:79581711 NPLOC4 0.32 7.6 0.38 2.93e-13 Eye color traits; LUSC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs2180341 0.618 rs6683 chr6:127610021 G/A cg24812749 chr6:127587940 RNF146 0.65 9.75 0.47 6.4e-20 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08375754 chr19:40724375 TTC9B 0.41 6.46 0.33 3.7e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7107174 1.000 rs2292573 chr11:78053139 A/G cg27205649 chr11:78285834 NARS2 -0.5 -5.65 -0.3 3.35e-8 Testicular germ cell tumor; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13401987 chr15:63569418 APH1B 0.46 6.27 0.32 1.14e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg06060754 chr5:176797920 RGS14 0.6 9.61 0.47 1.78e-19 Hemoglobin concentration;Hematocrit; LUSC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.84 -0.3 1.23e-8 Depression; LUSC cis rs713477 0.654 rs7143800 chr14:55917734 A/G cg13175173 chr14:55914753 NA -0.29 -6.03 -0.31 4.36e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs1691799 0.899 rs1168329 chr12:66731864 C/A cg16791601 chr12:66731901 HELB -0.71 -12.38 -0.56 3.1e-29 White blood cell count (basophil); LUSC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg24531977 chr5:56204891 C5orf35 -1.09 -15.89 -0.66 9.37e-43 Initial pursuit acceleration; LUSC cis rs62064224 0.791 rs17806082 chr17:30705346 G/C cg25809561 chr17:30822961 MYO1D 0.56 9.78 0.47 4.89e-20 Schizophrenia; LUSC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg02269571 chr22:50332266 NA -0.54 -8.08 -0.4 1.24e-14 Schizophrenia; LUSC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg13206674 chr6:150067644 NUP43 0.62 10.17 0.49 2.43e-21 Lung cancer; LUSC cis rs7940866 0.738 rs10894308 chr11:130891895 G/A cg12179176 chr11:130786555 SNX19 0.65 10.02 0.48 7.91e-21 Schizophrenia; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.35 0.46 1.35e-18 Prudent dietary pattern; LUSC cis rs1595825 0.838 rs16823400 chr2:198603229 A/G cg00982548 chr2:198649783 BOLL -0.57 -7.0 -0.36 1.44e-11 Ulcerative colitis; LUSC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg03433033 chr1:76189801 ACADM 0.84 15.34 0.64 1.44e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7122539 0.646 rs543191 chr11:66583779 T/G cg24851651 chr11:66362959 CCS 0.56 10.01 0.48 8.26e-21 HIV-1 susceptibility; LUSC cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.65 -10.38 -0.49 4.61e-22 Systemic lupus erythematosus; LUSC cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.72e-18 Monocyte percentage of white cells; LUSC cis rs16854884 0.657 rs7642774 chr3:143723272 T/A cg06585982 chr3:143692056 C3orf58 0.5 7.88 0.4 4.76e-14 Economic and political preferences (feminism/equality); LUSC cis rs10791323 0.572 rs10750551 chr11:133737462 G/A cg00579200 chr11:133705235 NA -0.4 -5.88 -0.31 9.73e-9 Childhood ear infection; LUSC cis rs931127 0.502 rs1466462 chr11:65419364 C/G cg27068330 chr11:65405492 SIPA1 0.72 10.42 0.5 3.36e-22 Systemic lupus erythematosus; LUSC cis rs7590368 0.683 rs56121730 chr2:10960866 C/T cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg22834771 chr12:69754056 YEATS4 -0.42 -6.03 -0.31 4.36e-9 Blood protein levels; LUSC cis rs12995491 0.933 rs13008732 chr2:88528771 G/A cg18302933 chr2:88491318 NA -0.35 -6.73 -0.35 7.41e-11 Response to metformin (IC50); LUSC cis rs7582720 0.945 rs72936860 chr2:203783484 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg05872129 chr22:39784769 NA -0.53 -8.69 -0.43 1.66e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6725517 0.737 rs7576788 chr2:25083310 A/G cg01884057 chr2:25150051 NA 0.4 9.32 0.45 1.59e-18 Breast cancer; LUSC cis rs939658 0.967 rs7172074 chr15:79452726 T/C cg17916960 chr15:79447300 NA 0.47 9.33 0.45 1.54e-18 Refractive error; LUSC cis rs7107174 0.892 rs10793310 chr11:78099014 T/G cg02023728 chr11:77925099 USP35 0.46 6.7 0.34 8.82e-11 Testicular germ cell tumor; LUSC cis rs5758659 0.633 rs762995 chr22:42672124 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.3 -6.27 -0.32 1.13e-9 Cognitive function; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13787029 chr2:42721631 KCNG3 0.44 6.26 0.32 1.17e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg09479241 chr17:27052676 TLCD1 0.43 5.96 0.31 6.29e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs79149102 0.579 rs7179097 chr15:75279240 T/G cg09165964 chr15:75287851 SCAMP5 -0.97 -8.23 -0.41 4.39e-15 Lung cancer; LUSC cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg21573476 chr21:45109991 RRP1B -0.36 -5.76 -0.3 1.87e-8 Mean corpuscular volume; LUSC trans rs4650994 0.544 rs2476560 chr1:178594919 A/G cg05059571 chr16:84539110 KIAA1609 0.46 8.7 0.43 1.54e-16 HDL cholesterol levels;HDL cholesterol; LUSC cis rs2282032 0.527 rs57011283 chr14:90767165 G/T cg14092571 chr14:90743983 NA 0.47 7.95 0.4 2.88e-14 Longevity; LUSC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs116988415 0.584 rs17180497 chr14:65269707 A/C cg00114569 chr14:65239327 SPTB -0.68 -7.57 -0.38 3.63e-13 Daytime sleep phenotypes; LUSC cis rs7605827 0.930 rs6737962 chr2:15526998 T/G cg19274914 chr2:15703543 NA 0.47 9.24 0.45 2.95e-18 Educational attainment (years of education); LUSC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.89 0.31 9.39e-9 Rheumatoid arthritis; LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg16325326 chr1:53192061 ZYG11B 0.69 11.17 0.52 7.98e-25 Monocyte count; LUSC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg12463550 chr7:65579703 CRCP -0.51 -7.41 -0.38 1.03e-12 Aortic root size; LUSC cis rs1568889 0.838 rs10458896 chr11:28057957 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.92 0.58 3e-31 Bipolar disorder; LUSC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg25282410 chr6:160211355 TCP1;MRPL18 1.13 17.23 0.69 4.9e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg26314531 chr2:26401878 FAM59B 0.75 10.1 0.48 4.27e-21 Gut microbiome composition (summer); LUSC cis rs8058578 1.000 rs6565197 chr16:30706477 T/C cg05768032 chr16:30646687 NA 0.4 5.96 0.31 6.32e-9 Multiple myeloma; LUSC trans rs7980799 0.716 rs1601008 chr12:33611352 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.65 -0.43 2.16e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg24675658 chr1:53192096 ZYG11B -0.65 -10.33 -0.49 6.84e-22 Monocyte count; LUSC cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg08807101 chr21:30365312 RNF160 0.78 13.94 0.61 4.08e-35 Dental caries; LUSC cis rs1153858 0.832 rs1145078 chr15:45682277 C/T cg26924012 chr15:45694286 SPATA5L1 1.13 20.38 0.74 1.46e-60 Homoarginine levels; LUSC cis rs7106204 0.514 rs2068454 chr11:24256166 C/G ch.11.24196551F chr11:24239977 NA -0.88 -10.0 -0.48 9.35e-21 Response to Homoharringtonine (cytotoxicity); LUSC trans rs7939886 0.841 rs79254833 chr11:55986896 T/C cg03929089 chr4:120376271 NA 0.82 6.13 0.32 2.55e-9 Myopia (pathological); LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg11965913 chr1:205819406 PM20D1 -0.54 -8.83 -0.44 5.98e-17 Menarche (age at onset); LUSC trans rs877282 0.898 rs10904546 chr10:757222 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.51 -0.34 2.71e-10 Uric acid levels; LUSC cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg13256891 chr4:100009986 ADH5 -0.43 -6.0 -0.31 5.06e-9 Alcohol dependence; LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg15790184 chr11:494944 RNH1 0.54 5.94 0.31 7.19e-9 Body mass index; LUSC cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg05043794 chr9:111880884 C9orf5 -0.34 -7.41 -0.38 1.03e-12 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg27014927 chr22:45403808 PHF21B -0.4 -6.19 -0.32 1.81e-9 Electrocardiographic conduction measures; LUSC cis rs4654899 1.000 rs4654896 chr1:21356930 T/C cg01072550 chr1:21505969 NA -0.56 -8.52 -0.42 5.53e-16 Superior frontal gyrus grey matter volume; LUSC trans rs330071 0.549 rs11785593 chr8:9256324 A/G cg15556689 chr8:8085844 FLJ10661 0.46 6.28 0.32 1.04e-9 Acne (severe); LUSC trans rs9329221 0.537 rs12678797 chr8:9978919 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.71 -0.39 1.42e-13 Neuroticism; LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg00149659 chr3:10157352 C3orf10 0.91 12.63 0.57 3.62e-30 Alzheimer's disease; LUSC cis rs6060987 1 rs6060987 chr20:30427077 T/A cg18721089 chr20:30220636 NA -0.37 -6.54 -0.34 2.35e-10 Mean corpuscular volume; LUSC cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22857025 chr5:266934 NA -1.15 -14.14 -0.61 6.97e-36 Breast cancer; LUSC cis rs8060686 0.623 rs6499162 chr16:68239460 T/C cg09835421 chr16:68378352 PRMT7 -0.45 -5.69 -0.3 2.78e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7481584 0.926 rs12806061 chr11:3008404 G/A cg08508325 chr11:3079039 CARS 0.31 5.96 0.31 6.46e-9 Calcium levels; LUSC cis rs3770081 1.000 rs2241435 chr2:86360916 C/G cg23655155 chr2:86332777 POLR1A;PTCD3 -1.1 -7.59 -0.38 3.17e-13 Facial emotion recognition (sad faces); LUSC cis rs4803468 1.000 rs2241710 chr19:41912092 G/C cg09537434 chr19:41945824 ATP5SL -0.9 -15.71 -0.65 4.81e-42 Height; LUSC cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg12011299 chr4:100065546 ADH4 -0.7 -10.8 -0.51 1.57e-23 Alcohol dependence; LUSC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg26116260 chr4:7069785 GRPEL1 1.04 15.18 0.64 6.1e-40 Monocyte percentage of white cells; LUSC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg18512352 chr11:47633146 NA -0.47 -9.55 -0.46 2.96e-19 Subjective well-being; LUSC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.5 -0.38 5.85e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg01689657 chr7:91764605 CYP51A1 0.33 6.03 0.31 4.29e-9 Breast cancer; LUSC cis rs950169 0.922 rs4338765 chr15:84916836 G/T cg17507749 chr15:85114479 UBE2QP1 0.68 8.74 0.43 1.18e-16 Schizophrenia; LUSC cis rs34734847 1.000 rs3752531 chr12:121157851 A/G cg27246729 chr12:121163418 ACADS 0.47 7.51 0.38 5.56e-13 Mean corpuscular volume; LUSC cis rs4654899 1.000 rs6702110 chr1:21515906 A/G cg01072550 chr1:21505969 NA -0.53 -8.08 -0.4 1.23e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg05347473 chr6:146136440 FBXO30 0.5 8.36 0.42 1.66e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg25703541 chr22:24373054 LOC391322 -0.88 -14.47 -0.62 3.69e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10791323 0.559 rs10750549 chr11:133730820 A/G cg15485101 chr11:133734466 NA 0.4 7.3 0.37 2.14e-12 Childhood ear infection; LUSC cis rs12980942 1.000 rs6957 chr19:41830606 T/C cg25627403 chr19:41769009 HNRNPUL1 0.57 6.15 0.32 2.16e-9 Coronary artery disease; LUSC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19741500 chr1:27930843 AHDC1 -0.45 -6.8 -0.35 4.74e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2204008 0.729 rs114133083 chr12:38182923 G/C cg13010199 chr12:38710504 ALG10B -0.52 -7.91 -0.4 3.89e-14 Bladder cancer; LUSC cis rs2286503 0.650 rs1990279 chr7:22890742 A/G cg04907244 chr7:22894795 SNORD93 -0.37 -6.25 -0.32 1.28e-9 Fibrinogen; LUSC cis rs11098499 0.564 rs11098507 chr4:120288286 G/A cg09307838 chr4:120376055 NA 0.7 10.45 0.5 2.72e-22 Corneal astigmatism; LUSC cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs67539049 1.000 rs67909842 chr8:11293429 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.4 -6.12 -0.32 2.68e-9 Itch intensity from mosquito bite; LUSC cis rs9815354 0.953 rs1716694 chr3:41986399 G/T cg03022575 chr3:42003672 ULK4 -0.52 -5.85 -0.3 1.19e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg22920501 chr2:26401640 FAM59B -0.79 -11.76 -0.54 5.97e-27 Gut microbiome composition (summer); LUSC cis rs9443645 0.527 rs1413968 chr6:79791042 A/G cg05283184 chr6:79620031 NA -0.47 -8.97 -0.44 2.13e-17 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03576123 chr11:487126 PTDSS2 -1.05 -11.18 -0.52 7.13e-25 Body mass index; LUSC cis rs9648716 0.515 rs38734 chr7:140706708 A/T cg23214464 chr7:140373596 ADCK2 0.7 6.46 0.33 3.68e-10 Type 2 diabetes; LUSC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg10356904 chr22:49881777 NA -0.31 -6.99 -0.36 1.49e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg20887711 chr4:1340912 KIAA1530 0.69 11.25 0.52 4.11e-25 Longevity; LUSC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg25566285 chr7:158114605 PTPRN2 0.35 6.53 0.34 2.52e-10 Calcium levels; LUSC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.69 -0.34 9.34e-11 Alzheimer's disease (late onset); LUSC cis rs9815354 0.812 rs73073364 chr3:41843058 T/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9486719 0.948 rs2472906 chr6:96875318 G/T cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC trans rs2201841 0.501 rs114407826 chr1:67742235 G/A cg16262963 chr14:104851903 NA -0.23 -6.03 -0.31 4.45e-9 Ulcerative colitis;Psoriasis;Crohn's disease; LUSC cis rs7927592 0.513 rs608343 chr11:68196830 T/C cg01657329 chr11:68192670 LRP5 -0.49 -7.67 -0.39 1.84e-13 Total body bone mineral density; LUSC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg15073853 chr19:18549131 ISYNA1 -0.32 -5.79 -0.3 1.64e-8 Breast cancer; LUSC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg05084668 chr3:125655381 ALG1L -0.52 -8.02 -0.4 1.86e-14 Blood pressure (smoking interaction); LUSC cis rs9658691 0.607 rs9658750 chr10:90766596 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -6.14 -0.32 2.35e-9 Mosquito bite size; LUSC trans rs637571 0.522 rs528736 chr11:65705108 A/G cg17712092 chr4:129076599 LARP1B 0.81 12.03 0.55 6.03e-28 Eosinophil percentage of white cells; LUSC cis rs2346177 0.875 rs4413204 chr2:46647092 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.55 -8.57 -0.42 4.02e-16 HDL cholesterol; LUSC cis rs9902453 0.817 rs2628170 chr17:28056612 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -9.57 -0.46 2.51e-19 Coffee consumption (cups per day); LUSC cis rs6933660 0.610 rs71549125 chr6:151770796 A/C cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.38 0.33 6.05e-10 Menarche (age at onset); LUSC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg14440974 chr22:39074834 NA -0.39 -6.44 -0.33 4.23e-10 Menopause (age at onset); LUSC cis rs10504229 0.636 rs114725691 chr8:58054292 C/T cg21724239 chr8:58056113 NA 0.57 6.62 0.34 1.4e-10 Developmental language disorder (linguistic errors); LUSC cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg24812749 chr6:127587940 RNF146 0.9 13.19 0.59 3e-32 Breast cancer; LUSC cis rs6121246 0.559 rs6060952 chr20:30382108 T/G cg13852791 chr20:30311386 BCL2L1 0.92 13.96 0.61 3.38e-35 Mean corpuscular hemoglobin; LUSC trans rs1973993 0.967 rs1555543 chr1:96944797 A/C cg10631902 chr5:14652156 NA 0.54 9.43 0.46 6.95e-19 Weight; LUSC cis rs79976124 0.879 rs12214948 chr6:66633603 G/A cg07460842 chr6:66804631 NA 0.69 8.65 0.43 2.17e-16 Type 2 diabetes; LUSC cis rs9581857 0.615 rs9581849 chr13:28005782 G/T cg22138327 chr13:27999177 GTF3A 0.89 9.45 0.46 6.21e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.49 -7.46 -0.38 7.61e-13 Lymphocyte counts; LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg18402987 chr7:1209562 NA 0.71 7.85 0.39 5.89e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2486288 0.656 rs11632651 chr15:45550838 C/T cg09092052 chr15:45571596 NA 0.46 6.36 0.33 6.52e-10 Glomerular filtration rate; LUSC trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg26513180 chr16:89883248 FANCA 0.62 9.92 0.48 1.72e-20 Vitiligo; LUSC cis rs12579753 1.000 rs12827923 chr12:82242067 G/A cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC trans rs6951245 0.638 rs74976697 chr7:1160505 C/T cg13565492 chr6:43139072 SRF -0.61 -6.97 -0.36 1.71e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12493885 0.585 rs61790900 chr3:153642726 A/G cg17054900 chr3:154042577 DHX36 -0.56 -5.94 -0.31 7.13e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs765787 0.530 rs3759892 chr15:45542709 A/G cg24006582 chr15:45444508 DUOX1 0.66 9.34 0.46 1.39e-18 Uric acid levels; LUSC cis rs2299587 0.560 rs3913556 chr8:17781401 A/G cg01800426 chr8:17659068 MTUS1 -0.49 -6.55 -0.34 2.21e-10 Economic and political preferences; LUSC cis rs672059 1.000 rs522372 chr1:183157449 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.55 -8.02 -0.4 1.75e-14 Hypertriglyceridemia; LUSC cis rs9311676 0.656 rs34579268 chr3:58410554 C/T cg13750441 chr3:58318267 PXK 0.35 6.95 0.36 1.95e-11 Systemic lupus erythematosus; LUSC cis rs8062405 1.000 rs1987472 chr16:28825777 C/T cg09754948 chr16:28834200 ATXN2L 0.44 6.47 0.33 3.56e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg25036284 chr2:26402008 FAM59B -0.69 -9.95 -0.48 1.35e-20 Gut microbiome composition (summer); LUSC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg26061582 chr7:22766209 IL6 0.48 6.97 0.36 1.75e-11 Lung cancer; LUSC cis rs2820315 0.505 rs10800792 chr1:201811144 G/A cg10061532 chr1:201886748 LMOD1 -0.23 -5.66 -0.3 3.22e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.16 0.32 2.11e-9 Mean platelet volume; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg11965913 chr1:205819406 PM20D1 -0.78 -16.17 -0.66 7.43e-44 Monocyte percentage of white cells; LUSC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.66 -0.34 1.11e-10 Lung cancer; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg14004847 chr7:1930337 MAD1L1 -0.5 -7.58 -0.38 3.54e-13 Bipolar disorder and schizophrenia; LUSC cis rs10782582 0.586 rs11161902 chr1:76392498 C/G cg10523679 chr1:76189770 ACADM -0.44 -6.26 -0.32 1.16e-9 Daytime sleep phenotypes; LUSC cis rs10779751 0.770 rs2486922 chr1:11124885 T/C cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC trans rs9929218 0.953 rs9939049 chr16:68812301 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.5 -0.53 5.27e-26 Colorectal cancer; LUSC cis rs1941023 0.503 rs2233238 chr11:60145441 G/C cg08716584 chr11:60157161 MS4A7 -0.65 -12.39 -0.56 2.92e-29 Congenital heart disease (maternal effect); LUSC cis rs12618769 1.000 rs72825725 chr2:99251259 C/A cg10123293 chr2:99228465 UNC50 0.43 5.96 0.31 6.29e-9 Bipolar disorder; LUSC cis rs500891 0.533 rs1342827 chr6:84161824 T/C cg08257003 chr6:84140564 ME1 0.36 8.79 0.43 7.77e-17 Platelet-derived growth factor BB levels; LUSC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.73 0.35 7.58e-11 Tonsillectomy; LUSC cis rs7267979 0.586 rs6050439 chr20:25192331 T/C cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.03e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9929218 0.954 rs1981871 chr16:68819007 C/T cg02972257 chr16:68554789 NA 0.42 5.77 0.3 1.86e-8 Colorectal cancer; LUSC cis rs2898681 0.581 rs11938140 chr4:53678057 T/A cg00338735 chr4:53728038 RASL11B 0.43 5.83 0.3 1.31e-8 Optic nerve measurement (cup area); LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg17264618 chr3:40429014 ENTPD3 -0.32 -6.88 -0.35 3.02e-11 Renal cell carcinoma; LUSC trans rs11039798 0.502 rs961863 chr11:48417021 T/C cg03929089 chr4:120376271 NA -0.58 -6.16 -0.32 2.05e-9 Axial length; LUSC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg12560992 chr17:57184187 TRIM37 0.85 15.35 0.64 1.26e-40 Intelligence (multi-trait analysis); LUSC cis rs950169 0.922 rs2033284 chr15:84946273 C/T cg17173187 chr15:85201210 NMB 0.36 6.33 0.33 8.09e-10 Schizophrenia; LUSC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg13628971 chr7:2884303 GNA12 0.53 7.2 0.37 3.9e-12 Height; LUSC trans rs6089829 0.962 rs4809462 chr20:61661560 A/G cg15934090 chr1:100435551 SLC35A3 0.47 8.09 0.4 1.1e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg04871131 chr7:94954202 PON1 -0.38 -5.95 -0.31 6.61e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9467773 1.000 rs1884949 chr6:26568067 G/A cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg23711669 chr6:146136114 FBXO30 0.89 16.67 0.67 7.9e-46 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15214567 chr21:44527826 U2AF1 -0.43 -6.47 -0.33 3.39e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.45 5.83 0.3 1.33e-8 Renal function-related traits (BUN); LUSC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg04315214 chr1:2043799 PRKCZ -0.4 -8.14 -0.41 8.18e-15 Height; LUSC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg22535103 chr8:58192502 C8orf71 -0.84 -10.03 -0.48 7.15e-21 Developmental language disorder (linguistic errors); LUSC cis rs9326248 0.581 rs10892048 chr11:116814596 A/G cg11861562 chr11:117069780 TAGLN 0.34 6.65 0.34 1.16e-10 Blood protein levels; LUSC cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg23711669 chr6:146136114 FBXO30 0.83 15.19 0.64 5.29e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs4959270 1.000 rs4959270 chr6:457748 A/C cg09757644 chr6:447497 NA -0.3 -6.21 -0.32 1.59e-9 Limited cutaneous systemic scleroderma; LUSC cis rs13720 0.722 rs163791 chr20:57576174 G/A cg23907860 chr20:57583709 CTSZ -0.45 -5.97 -0.31 6e-9 Platelet distribution width; LUSC cis rs12472274 1.000 rs12472274 chr2:239095422 G/A cg17459225 chr2:239074497 NA 0.63 10.01 0.48 8.55e-21 Phospholipid levels (plasma); LUSC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.76 -0.6 1.97e-34 Intelligence (multi-trait analysis); LUSC cis rs2692947 0.795 rs2252697 chr2:96778190 G/C cg22654517 chr2:96458247 NA -0.36 -7.2 -0.37 4.06e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.67 0.39 1.85e-13 Eosinophil percentage of white cells; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.82 -0.3 1.4e-8 Platelet count; LUSC cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg01028140 chr2:1542097 TPO -0.44 -6.92 -0.35 2.39e-11 IgG glycosylation; LUSC cis rs1712517 0.873 rs1163083 chr10:105038455 T/A cg05636881 chr10:105038444 INA 0.4 6.85 0.35 3.63e-11 Migraine; LUSC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg25427524 chr10:38739819 LOC399744 -0.65 -11.85 -0.54 2.83e-27 Extrinsic epigenetic age acceleration; LUSC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 7.04 0.36 1.12e-11 Intelligence (multi-trait analysis); LUSC cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.97 -0.48 1.17e-20 Body mass index; LUSC cis rs17621444 0.522 rs1889439 chr10:121810861 G/T cg02041677 chr10:121771263 NA -0.34 -6.54 -0.34 2.26e-10 IgG glycosylation; LUSC cis rs1843834 0.931 rs10170573 chr2:225552916 A/G cg22455342 chr2:225449267 CUL3 0.46 6.16 0.32 2.14e-9 IgE levels in asthmatics (D.p. specific); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg15886017 chr9:96278586 FAM120A 0.4 6.1 0.32 2.92e-9 Cognitive function;Information processing speed; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg00684032 chr4:1343700 KIAA1530 0.35 6.32 0.33 8.43e-10 Obesity-related traits; LUSC trans rs11098499 0.697 rs28655325 chr4:120372999 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg18827107 chr12:86230957 RASSF9 0.47 7.02 0.36 1.23e-11 Major depressive disorder; LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg27398817 chr8:82754497 SNX16 -0.66 -8.44 -0.42 1e-15 Diastolic blood pressure; LUSC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg26677194 chr12:130822605 PIWIL1 0.57 8.36 0.42 1.78e-15 Menopause (age at onset); LUSC cis rs3808502 0.525 rs9650661 chr8:11427133 G/T cg27411982 chr8:10470053 RP1L1 -0.46 -7.09 -0.36 7.8e-12 Neuroticism; LUSC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.19e-9 Mean platelet volume; LUSC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.33 -0.37 1.74e-12 Aortic root size; LUSC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg24296786 chr1:45957014 TESK2 0.53 8.13 0.41 8.55e-15 High light scatter reticulocyte count; LUSC cis rs6912958 0.500 rs3828759 chr6:87806640 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.12 -0.45 6.98e-18 Monocyte percentage of white cells; LUSC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg13683864 chr3:40499215 RPL14 -1.06 -18.53 -0.71 3.26e-53 Renal cell carcinoma; LUSC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg24920358 chr1:40204285 PPIE 0.6 10.8 0.51 1.64e-23 Blood protein levels; LUSC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg11871910 chr12:69753446 YEATS4 0.93 17.13 0.68 1.14e-47 Cerebrospinal fluid biomarker levels; LUSC cis rs7719624 1.000 rs7719624 chr5:135377566 A/G cg12897067 chr5:135418308 NA -0.39 -5.73 -0.3 2.22e-8 Response to cytidine analogues (gemcitabine); LUSC cis rs601339 0.938 rs1696344 chr12:123183059 C/T cg11919336 chr12:123188078 GPR109A 0.44 6.58 0.34 1.87e-10 Adiponectin levels; LUSC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg02038168 chr22:39784481 NA 0.49 7.97 0.4 2.59e-14 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs3947 0.738 rs1293328 chr8:11695060 C/T cg00262122 chr8:11665843 FDFT1 -0.47 -6.1 -0.32 2.86e-9 Blood protein levels; LUSC cis rs9325144 0.600 rs7312522 chr12:38730423 A/G cg13010199 chr12:38710504 ALG10B 0.47 7.27 0.37 2.56e-12 Morning vs. evening chronotype; LUSC cis rs9322193 0.543 rs9371533 chr6:150210681 G/A cg13206674 chr6:150067644 NUP43 0.45 6.76 0.35 6.32e-11 Lung cancer; LUSC trans rs4718428 0.705 rs13220977 chr7:66337648 A/T cg18876405 chr7:65276391 NA -0.49 -6.67 -0.34 1.04e-10 Corneal structure; LUSC cis rs4730250 0.707 rs257375 chr7:106799043 A/G cg02696742 chr7:106810147 HBP1 -0.58 -7.85 -0.39 5.56e-14 Osteoarthritis; LUSC cis rs6762 0.719 rs4895 chr11:840477 A/G cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.27 -0.41 3.15e-15 Mean platelet volume; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00411741 chr19:18208476 MAST3 0.7 6.03 0.31 4.35e-9 Cognitive performance; LUSC cis rs6714710 0.603 rs6746768 chr2:98466647 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.18e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg25838465 chr1:92012736 NA -0.74 -15.08 -0.64 1.55e-39 Breast cancer; LUSC cis rs1559088 0.895 rs13345542 chr19:33586739 G/C cg17764715 chr19:33622953 WDR88 0.6 8.29 0.41 2.72e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9943753 0.525 rs7952909 chr12:109808573 A/T cg19025524 chr12:109796872 NA 0.38 7.02 0.36 1.23e-11 HDL cholesterol; LUSC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg03709012 chr19:19516395 GATAD2A -0.76 -11.85 -0.54 2.74e-27 Tonsillectomy; LUSC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg09085632 chr11:111637200 PPP2R1B -1.05 -16.77 -0.68 3.24e-46 Primary sclerosing cholangitis; LUSC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg08798685 chr6:27730294 NA -0.59 -5.94 -0.31 7.19e-9 Depression; LUSC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg06640241 chr16:89574553 SPG7 0.88 15.95 0.66 5.51e-43 Multiple myeloma (IgH translocation); LUSC cis rs17270561 0.666 rs1141034 chr6:25780332 C/T cg17691542 chr6:26056736 HIST1H1C 0.49 6.74 0.35 6.78e-11 Iron status biomarkers; LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg14004847 chr7:1930337 MAD1L1 -0.53 -7.83 -0.39 6.68e-14 Bipolar disorder and schizophrenia; LUSC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 10.1 0.48 4.26e-21 Hip circumference adjusted for BMI; LUSC cis rs2274273 0.967 rs8013027 chr14:55610940 C/G cg04306507 chr14:55594613 LGALS3 0.54 12.09 0.55 3.67e-28 Protein biomarker; LUSC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.35 -0.53 1.73e-25 Mean corpuscular volume; LUSC cis rs5753037 0.838 rs131293 chr22:30171031 T/G cg11564601 chr22:30592435 NA 0.33 5.8 0.3 1.5e-8 Type 1 diabetes; LUSC cis rs7589342 0.929 rs6725519 chr2:106445209 A/G cg14210321 chr2:106509881 NCK2 0.54 8.3 0.41 2.54e-15 Addiction; LUSC trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7592578 0.825 rs12477369 chr2:191455624 G/T cg10560079 chr2:191398806 TMEM194B 0.67 8.06 0.4 1.41e-14 Diastolic blood pressure; LUSC trans rs877282 0.947 rs4133015 chr10:774131 T/C cg22713356 chr15:30763199 NA 1.06 15.22 0.64 4.19e-40 Uric acid levels; LUSC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg18099408 chr3:52552593 STAB1 0.36 6.11 0.32 2.72e-9 Electroencephalogram traits; LUSC cis rs7589728 0.925 rs78829281 chr2:88502293 T/A cg04511125 chr2:88470314 THNSL2 0.71 6.64 0.34 1.25e-10 Plasma clusterin levels; LUSC cis rs10208940 0.920 rs7580719 chr2:68833572 A/G cg12452813 chr2:68675892 NA -0.56 -6.06 -0.31 3.76e-9 Urate levels in lean individuals; LUSC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg21361702 chr7:150065534 REPIN1 0.48 6.22 0.32 1.49e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs12421382 0.659 rs1439518 chr11:109382921 T/G cg11473876 chr11:109292803 C11orf87 0.4 6.5 0.34 2.92e-10 Schizophrenia; LUSC cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg15744005 chr10:104629667 AS3MT -0.27 -5.71 -0.3 2.44e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17255340 0.539 rs1144188 chr6:83984097 A/G cg08257003 chr6:84140564 ME1 0.31 7.54 0.38 4.52e-13 Platelet-derived growth factor BB levels; LUSC cis rs4727027 0.522 rs6956736 chr7:148893472 G/C cg23583168 chr7:148888333 NA -0.8 -11.99 -0.55 8.43e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg23505145 chr19:12996616 KLF1 0.64 10.7 0.51 3.62e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg10802521 chr3:52805072 NEK4 -0.47 -6.84 -0.35 3.7e-11 Bipolar disorder; LUSC cis rs2078087 0.522 rs594488 chr1:183241262 G/A cg13843938 chr1:183241246 NMNAT2 -0.42 -6.82 -0.35 4.2e-11 Obesity-related traits; LUSC cis rs7107174 1.000 rs2512546 chr11:77957276 T/C cg02023728 chr11:77925099 USP35 0.47 7.08 0.36 8.67e-12 Testicular germ cell tumor; LUSC cis rs4776059 0.798 rs2414160 chr15:52872530 G/C cg25063058 chr15:52860530 ARPP19 -0.46 -5.69 -0.3 2.73e-8 Schizophrenia; LUSC cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.95 -0.31 6.87e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs1843834 0.898 rs11887386 chr2:225526975 T/G cg22455342 chr2:225449267 CUL3 0.44 6.19 0.32 1.73e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.94 0.55 1.27e-27 Personality dimensions; LUSC cis rs2481665 0.617 rs12732781 chr1:62518459 T/C cg18591186 chr1:62594603 INADL -0.39 -6.2 -0.32 1.65e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1775715 0.737 rs1541260 chr10:32105570 C/T cg18675610 chr10:32216311 ARHGAP12 0.29 6.34 0.33 7.56e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg19592336 chr6:28129416 ZNF389 0.54 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg08219700 chr8:58056026 NA 0.72 8.29 0.41 2.9e-15 Developmental language disorder (linguistic errors); LUSC cis rs910316 0.763 rs6574205 chr14:75453039 G/C cg08847533 chr14:75593920 NEK9 0.85 14.98 0.63 3.67e-39 Height; LUSC cis rs2004776 0.656 rs4847008 chr1:230865226 G/T cg07502417 chr1:230849801 AGT 0.25 5.88 0.31 1.01e-8 Diastolic blood pressure; LUSC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg14500267 chr11:67383377 NA 0.33 6.18 0.32 1.85e-9 Mean corpuscular volume; LUSC cis rs644799 0.540 rs10831422 chr11:95478968 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.76 0.47 5.78e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3106136 0.546 rs7685121 chr4:95175682 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.52 -0.42 5.42e-16 Capecitabine sensitivity; LUSC cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg01884057 chr2:25150051 NA -0.47 -11.27 -0.52 3.54e-25 Body mass index; LUSC cis rs10782582 0.593 rs11163967 chr1:76154185 T/C cg22875332 chr1:76189707 ACADM -0.4 -6.07 -0.32 3.53e-9 Daytime sleep phenotypes; LUSC cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg18252515 chr7:66147081 NA -1.18 -13.38 -0.59 5.56e-33 Diabetic kidney disease; LUSC cis rs17253792 0.822 rs17253744 chr14:56161950 C/G cg01858014 chr14:56050164 KTN1 -0.8 -6.05 -0.31 3.82e-9 Putamen volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21012866 chr6:10747898 TMEM14B -0.43 -6.3 -0.33 9.3e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.46 6.43 0.33 4.34e-10 Alzheimer's disease (late onset); LUSC cis rs796364 0.587 rs7588746 chr2:200986345 A/G cg23649088 chr2:200775458 C2orf69 0.52 7.36 0.37 1.43e-12 Schizophrenia; LUSC cis rs4713675 0.565 rs9394161 chr6:33669793 G/C cg14003231 chr6:33640908 ITPR3 0.31 5.96 0.31 6.53e-9 Plateletcrit; LUSC cis rs963731 0.579 rs4643520 chr2:39229464 T/C cg04010122 chr2:39346883 SOS1 -0.79 -5.73 -0.3 2.2e-8 Corticobasal degeneration; LUSC cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg11502198 chr6:26597334 ABT1 0.55 8.2 0.41 5.23e-15 Intelligence (multi-trait analysis); LUSC cis rs8072100 0.744 rs34537623 chr17:45530203 A/G cg08085267 chr17:45401833 C17orf57 -0.54 -8.54 -0.42 4.65e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.34 0.56 4.46e-29 Colorectal cancer; LUSC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg06481639 chr22:41940642 POLR3H -0.51 -5.76 -0.3 1.86e-8 Vitiligo; LUSC cis rs61931739 0.591 rs10743834 chr12:33916129 A/C cg06521331 chr12:34319734 NA -0.41 -6.68 -0.34 9.72e-11 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17439093 chr7:107302364 SLC26A4;LOC286002 0.74 6.46 0.33 3.75e-10 Cognitive performance; LUSC cis rs7829975 0.508 rs4841006 chr8:8501474 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -7.01 -0.36 1.34e-11 Mood instability; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg20821713 chr7:1055600 C7orf50 -0.47 -7.7 -0.39 1.58e-13 Longevity;Endometriosis; LUSC cis rs6692729 0.933 rs1295640 chr1:227070378 C/T cg10327440 chr1:227177885 CDC42BPA -0.51 -7.32 -0.37 1.91e-12 Electrodermal activity; LUSC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg20503657 chr10:835505 NA 0.96 12.87 0.58 4.67e-31 Eosinophil percentage of granulocytes; LUSC cis rs2573652 0.928 rs2581348 chr15:100514063 C/T cg09918751 chr15:100517450 ADAMTS17 -0.41 -7.54 -0.38 4.45e-13 Height; LUSC cis rs7647973 0.626 rs9835157 chr3:49797769 G/A cg13072238 chr3:49761600 GMPPB 0.65 8.33 0.41 2.14e-15 Menarche (age at onset); LUSC cis rs1322512 0.917 rs2011836 chr6:152954725 A/G cg27316956 chr6:152958899 SYNE1 -0.36 -6.04 -0.31 4.06e-9 Tonometry; LUSC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15541040 chr2:3486749 NA -0.58 -9.1 -0.45 8.15e-18 Neurofibrillary tangles; LUSC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg23262073 chr20:60523788 NA -0.42 -5.95 -0.31 6.71e-9 Body mass index; LUSC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 9.61 0.47 1.89e-19 Mean platelet volume; LUSC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg24531977 chr5:56204891 C5orf35 -1.08 -16.08 -0.66 1.79e-43 Initial pursuit acceleration; LUSC trans rs8072100 0.846 rs7214799 chr17:45702099 C/T cg04995722 chr7:26192034 NFE2L3 0.38 6.13 0.32 2.43e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -8.16 -0.41 6.99e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg11266682 chr4:10021025 SLC2A9 0.57 10.64 0.5 5.82e-23 Bone mineral density; LUSC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg17971929 chr21:40555470 PSMG1 -0.6 -9.71 -0.47 8.38e-20 Cognitive function; LUSC cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.55 -0.34 2.14e-10 Monocyte percentage of white cells; LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg27535305 chr1:53392650 SCP2 -0.49 -9.71 -0.47 8.84e-20 Monocyte count; LUSC cis rs7071206 0.947 rs1356090 chr10:79395312 T/C cg07817648 chr10:79422355 NA -0.57 -7.33 -0.37 1.73e-12 Bone mineral density; LUSC cis rs7851660 0.839 rs7027221 chr9:100662379 T/C cg13688889 chr9:100608707 NA -0.54 -8.44 -0.42 9.53e-16 Strep throat; LUSC cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -11.8 -0.54 4.25e-27 Chronic sinus infection; LUSC trans rs61931739 0.534 rs814669 chr12:34102459 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.74 0.51 2.52e-23 Morning vs. evening chronotype; LUSC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg26513180 chr16:89883248 FANCA 0.79 6.38 0.33 5.97e-10 Skin colour saturation; LUSC cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg08999081 chr20:33150536 PIGU -0.54 -10.73 -0.51 2.88e-23 Glomerular filtration rate (creatinine); LUSC cis rs9287719 0.967 rs4668691 chr2:10740494 C/T cg00105475 chr2:10696890 NA 0.38 6.35 0.33 6.94e-10 Prostate cancer; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg20607798 chr8:58055168 NA 0.52 5.66 0.3 3.29e-8 Developmental language disorder (linguistic errors); LUSC trans rs2018683 0.768 rs10282015 chr7:29022138 G/A cg19402173 chr7:128379420 CALU -0.58 -9.44 -0.46 6.62e-19 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg27279351 chr12:120934652 DYNLL1 0.64 8.49 0.42 6.72e-16 High light scatter reticulocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17498662 chr6:41754992 PRICKLE4;TOMM6 -0.43 -6.36 -0.33 6.72e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg04362960 chr10:104952993 NT5C2 -0.52 -6.55 -0.34 2.15e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7903847 0.692 rs7900255 chr10:99157575 G/A cg20016023 chr10:99160130 RRP12 -0.32 -7.72 -0.39 1.35e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs4237845 0.680 rs10877033 chr12:58283731 T/C cg00677455 chr12:58241039 CTDSP2 0.49 7.29 0.37 2.2e-12 Intelligence (multi-trait analysis); LUSC cis rs8078723 0.901 rs709591 chr17:38175561 T/A cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -7.02 -0.36 1.25e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.99e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9463078 0.764 rs9369516 chr6:44833598 C/T cg25276700 chr6:44698697 NA -0.29 -5.72 -0.3 2.36e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg02018176 chr4:1364513 KIAA1530 0.51 8.83 0.43 6.12e-17 Obesity-related traits; LUSC cis rs9549367 0.789 rs912012 chr13:113886152 G/A cg00898013 chr13:113819073 PROZ -0.59 -8.52 -0.42 5.74e-16 Platelet distribution width; LUSC cis rs12989701 0.877 rs36085158 chr2:127869982 C/T cg08168897 chr2:127865431 BIN1 0.71 9.36 0.46 1.2e-18 Alzheimer's disease (late onset); LUSC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg13535736 chr9:111863775 C9orf5 -0.37 -6.12 -0.32 2.68e-9 Menarche (age at onset); LUSC cis rs11030122 0.702 rs10835402 chr11:3990914 T/C cg18678763 chr11:4115507 RRM1 -0.45 -5.75 -0.3 2.04e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs2219968 0.962 rs6995342 chr8:78951749 A/T cg00738934 chr8:78996279 NA 0.37 6.65 0.34 1.21e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 8.84 0.44 5.69e-17 Menarche (age at onset); LUSC cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.02e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs1595825 0.891 rs73054827 chr2:198649905 G/A cg00982548 chr2:198649783 BOLL -0.57 -7.21 -0.37 3.73e-12 Ulcerative colitis; LUSC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08704250 chr15:31115839 NA -0.47 -7.11 -0.36 7.03e-12 Huntington's disease progression; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.69 -0.34 9.64e-11 Electroencephalogram traits; LUSC trans rs11098499 0.818 rs7688802 chr4:120451668 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21172538 chr5:68513532 MRPS36 0.74 6.08 0.32 3.23e-9 Cognitive performance; LUSC cis rs10992471 0.528 rs10820975 chr9:95211922 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.27 -0.32 1.14e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg22117172 chr7:91764530 CYP51A1 -0.33 -5.88 -0.31 9.88e-9 Breast cancer; LUSC cis rs77106637 1.000 rs11602858 chr11:72615069 C/G cg04827223 chr11:72435913 ARAP1 -0.71 -8.99 -0.44 1.9e-17 Type 2 diabetes; LUSC cis rs1018836 0.923 rs9693182 chr8:91621876 T/C cg16814680 chr8:91681699 NA -0.77 -12.99 -0.58 1.66e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2835872 0.965 rs2835850 chr21:39012977 A/G cg20424643 chr21:39039972 KCNJ6 0.39 5.81 0.3 1.44e-8 Electroencephalographic traits in alcoholism; LUSC cis rs4363385 0.510 rs6686526 chr1:153044996 T/C cg25856811 chr1:152973957 SPRR3 -0.37 -6.11 -0.32 2.78e-9 Inflammatory skin disease; LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg09033563 chr22:24373618 LOC391322 0.64 10.23 0.49 1.5e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18404041 chr3:52824283 ITIH1 -0.55 -10.39 -0.49 4.38e-22 Bipolar disorder; LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18582848 chr10:72142533 LRRC20 -0.43 -6.17 -0.32 2.01e-9 Electrocardiographic conduction measures; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg07167872 chr1:205819463 PM20D1 -0.44 -6.77 -0.35 5.93e-11 Menarche (age at onset); LUSC cis rs734999 0.566 rs10797435 chr1:2534801 G/C cg18932078 chr1:2524107 MMEL1 0.32 7.04 0.36 1.13e-11 Ulcerative colitis; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg18876405 chr7:65276391 NA -0.53 -8.58 -0.43 3.52e-16 Calcium levels; LUSC cis rs9796 0.870 rs11854472 chr15:41357687 G/A cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.98 -0.36 1.55e-11 Menopause (age at onset); LUSC cis rs9354308 0.933 rs2814134 chr6:66566658 C/G cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg11764359 chr7:65958608 NA -0.69 -10.98 -0.51 3.75e-24 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05421946 chr3:58223373 ABHD6 -0.42 -6.22 -0.32 1.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs17685 0.712 rs10235086 chr7:75833138 G/T cg19862616 chr7:65841803 NCRNA00174 1.1 18.01 0.7 3.59e-51 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg25427524 chr10:38739819 LOC399744 0.63 11.14 0.52 9.97e-25 Extrinsic epigenetic age acceleration; LUSC cis rs4566357 0.615 rs2894626 chr2:227916039 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -8.14 -0.41 8.12e-15 Coronary artery disease; LUSC cis rs968451 0.789 rs1003644 chr22:39676744 G/A cg17798944 chr22:39715225 SNORD43;RPL3 0.67 9.38 0.46 1.03e-18 Primary biliary cholangitis; LUSC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.37 -0.42 1.64e-15 Personality dimensions; LUSC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg03806693 chr22:41940476 POLR3H -1.06 -15.34 -0.64 1.37e-40 Vitiligo; LUSC cis rs2404602 0.692 rs12437733 chr15:77155562 A/G cg26408565 chr15:76604113 ETFA -0.48 -7.54 -0.38 4.56e-13 Blood metabolite levels; LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 4.97e-14 Prudent dietary pattern; LUSC cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg06784218 chr1:46089804 CCDC17 -0.5 -9.59 -0.46 2.17e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9309473 0.607 rs7586361 chr2:73601606 G/A cg20560298 chr2:73613845 ALMS1 -0.56 -8.39 -0.42 1.39e-15 Metabolite levels; LUSC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg07636037 chr3:49044803 WDR6 0.93 15.04 0.64 2.15e-39 Parkinson's disease; LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg25036284 chr2:26402008 FAM59B -0.74 -10.97 -0.51 3.97e-24 Gut microbiome composition (summer); LUSC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg15704280 chr7:45808275 SEPT13 -0.5 -6.93 -0.35 2.14e-11 HDL cholesterol; LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg03354898 chr7:1950403 MAD1L1 -0.43 -8.63 -0.43 2.57e-16 Bipolar disorder and schizophrenia; LUSC trans rs6598955 0.671 rs6658935 chr1:26568912 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.69 -0.43 1.65e-16 Obesity-related traits; LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -7.55 -0.38 4.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg07936489 chr17:37558343 FBXL20 0.72 10.01 0.48 8.24e-21 Glomerular filtration rate (creatinine); LUSC cis rs9640161 0.830 rs17173703 chr7:150068620 C/T cg27494647 chr7:150038898 RARRES2 0.42 6.27 0.32 1.13e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.37 5.65 0.3 3.45e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1215050 0.755 rs9991112 chr4:98651479 A/C cg05340658 chr4:99064831 C4orf37 -0.41 -6.45 -0.33 4.01e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7312933 0.558 rs11181501 chr12:42822671 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.91 0.35 2.51e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs823156 1.000 rs823156 chr1:205764640 G/A cg07157834 chr1:205819609 PM20D1 0.48 5.66 0.3 3.21e-8 Parkinson's disease; LUSC cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs4629710 0.592 rs4310080 chr6:131538377 T/G cg12606694 chr6:131520996 AKAP7 0.61 9.29 0.45 2.09e-18 Multiple myeloma (IgH translocation); LUSC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg03806693 chr22:41940476 POLR3H 0.9 12.63 0.57 3.59e-30 Vitiligo; LUSC cis rs12318506 0.826 rs11180438 chr12:75668035 T/G cg04728562 chr12:75699417 CAPS2 -0.76 -5.97 -0.31 6.19e-9 Coronary artery calcification; LUSC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg19046167 chr17:80928561 B3GNTL1 0.4 6.46 0.33 3.81e-10 Breast cancer; LUSC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg00966380 chr12:47633443 NA 0.53 7.03 0.36 1.18e-11 Cognitive function;Information processing speed; LUSC cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC trans rs853679 0.607 rs13190888 chr6:28285985 G/A cg01620082 chr3:125678407 NA -0.79 -7.53 -0.38 4.89e-13 Depression; LUSC cis rs8049040 0.609 rs16972805 chr16:71478249 A/G cg08717414 chr16:71523259 ZNF19 0.4 5.74 0.3 2.07e-8 Blood protein levels; LUSC cis rs611744 0.538 rs59930666 chr8:109262296 T/C cg21045802 chr8:109455806 TTC35 0.47 7.28 0.37 2.42e-12 Dupuytren's disease; LUSC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg14019146 chr3:50243930 SLC38A3 -0.32 -7.06 -0.36 9.67e-12 Intelligence (multi-trait analysis); LUSC cis rs9902453 1.000 rs8065261 chr17:28418041 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.56 -8.45 -0.42 9.17e-16 Coffee consumption (cups per day); LUSC cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -8.96 -0.44 2.41e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg17554472 chr22:41940697 POLR3H 0.48 5.91 0.31 8.32e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg24503407 chr1:205819492 PM20D1 0.93 17.97 0.7 5.5e-51 Menarche (age at onset); LUSC cis rs2625529 0.529 rs1552133 chr15:72232897 T/A cg16672083 chr15:72433130 SENP8 0.49 8.08 0.4 1.21e-14 Red blood cell count; LUSC cis rs3736594 0.513 rs62131882 chr2:27765480 T/C cg27432699 chr2:27873401 GPN1 0.67 8.86 0.44 4.69e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.39 6.26 0.32 1.22e-9 Menopause (age at onset); LUSC trans rs2736345 0.516 rs7844858 chr8:11392659 T/A cg15556689 chr8:8085844 FLJ10661 0.46 6.49 0.33 3.02e-10 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs7173743 1.000 rs4438276 chr15:79138565 A/G cg00540400 chr15:79124168 NA -0.33 -5.69 -0.3 2.85e-8 Coronary artery disease; LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC trans rs55944332 0.738 rs3901734 chr2:145769102 T/C cg12396057 chr1:167508884 NA 0.33 5.98 0.31 5.88e-9 Diastolic blood pressure; LUSC cis rs7249142 0.561 rs4808185 chr19:19296217 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.33 -5.97 -0.31 6.1e-9 IgG glycosylation; LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg04282206 chr17:62833786 PLEKHM1P 0.6 8.54 0.42 4.89e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs10435719 0.902 rs7006538 chr8:11804982 A/G cg06636001 chr8:8085503 FLJ10661 0.53 7.97 0.4 2.51e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs11098499 0.629 rs28369518 chr4:120271630 T/C cg24375607 chr4:120327624 NA 0.67 10.54 0.5 1.33e-22 Corneal astigmatism; LUSC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.95 0.44 2.6e-17 Breast cancer; LUSC cis rs9309473 0.950 rs10169213 chr2:73787234 G/C cg20560298 chr2:73613845 ALMS1 -0.45 -6.52 -0.34 2.66e-10 Metabolite levels; LUSC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg16339924 chr4:17578868 LAP3 0.59 9.2 0.45 3.85e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10782582 0.609 rs5745430 chr1:76332994 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.3 -0.33 9.31e-10 Daytime sleep phenotypes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03115649 chr1:179851535 TOR1AIP1 -0.57 -6.56 -0.34 2.02e-10 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg04369109 chr6:150039330 LATS1 -0.57 -8.32 -0.41 2.2e-15 Lung cancer; LUSC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg21132104 chr15:45694354 SPATA5L1 0.57 8.0 0.4 2.1e-14 Homoarginine levels; LUSC cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.45 -6.28 -0.33 1.04e-9 Multiple sclerosis; LUSC cis rs3741151 0.773 rs73544720 chr11:73173496 A/G cg17517138 chr11:73019481 ARHGEF17 0.96 8.16 0.41 6.73e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1348850 0.668 rs2365619 chr2:178497366 A/G cg22681709 chr2:178499509 PDE11A 0.52 8.28 0.41 3.03e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11644478 chr21:40555479 PSMG1 0.92 17.52 0.69 3.3e-49 Cognitive function; LUSC trans rs60843830 1.000 rs3791224 chr2:221981 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.64 0.5 5.68e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg18876405 chr7:65276391 NA 0.58 9.4 0.46 8.87e-19 Aortic root size; LUSC cis rs3862030 0.668 rs12781718 chr10:104227433 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.92 -0.44 3.02e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs4443100 0.917 rs5996460 chr22:23393090 G/A cg21100191 chr22:23484243 RTDR1 0.53 6.47 0.33 3.58e-10 Serum parathyroid hormone levels; LUSC cis rs9341808 0.935 rs4706113 chr6:80839315 C/T cg08355045 chr6:80787529 NA 0.52 9.19 0.45 4.37e-18 Sitting height ratio; LUSC trans rs61931739 0.517 rs7975714 chr12:34055611 T/C cg26384229 chr12:38710491 ALG10B 0.72 11.36 0.53 1.66e-25 Morning vs. evening chronotype; LUSC cis rs1348850 0.914 rs12616443 chr2:178315751 A/G cg22681709 chr2:178499509 PDE11A -0.5 -9.28 -0.45 2.23e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs7939886 0.920 rs79521305 chr11:55811332 G/A cg03929089 chr4:120376271 NA 0.77 6.33 0.33 8e-10 Myopia (pathological); LUSC cis rs17685 0.736 rs4732594 chr7:75753273 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4363385 0.818 rs11205176 chr1:153002481 A/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg25039879 chr17:56429692 SUPT4H1 0.49 6.93 0.35 2.24e-11 Cognitive test performance; LUSC cis rs9660992 0.639 rs1151786 chr1:205227760 G/C cg00857998 chr1:205179979 DSTYK 0.6 8.85 0.44 5.12e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg05043794 chr9:111880884 C9orf5 -0.33 -7.14 -0.36 5.75e-12 Menarche (age at onset); LUSC cis rs2387326 0.717 rs10829341 chr10:129944226 G/A cg16087940 chr10:129947807 NA -0.39 -6.0 -0.31 5.27e-9 Select biomarker traits; LUSC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.2 0.32 1.71e-9 Schizophrenia; LUSC cis rs2073300 1.000 rs6137971 chr20:23456429 G/T cg12062639 chr20:23401060 NAPB 0.76 5.9 0.31 8.97e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7364180 0.582 rs139568 chr22:42210985 C/T cg03806693 chr22:41940476 POLR3H 0.6 9.09 0.45 9.19e-18 Alzheimer's disease biomarkers; LUSC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg21862992 chr11:68658383 NA 0.51 8.13 0.41 8.56e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg13010199 chr12:38710504 ALG10B 0.49 7.48 0.38 6.8e-13 Morning vs. evening chronotype; LUSC trans rs9929218 0.817 rs3114402 chr16:68719607 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.89 -13.93 -0.61 4.45e-35 Colorectal cancer; LUSC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -5.71 -0.3 2.49e-8 Developmental language disorder (linguistic errors); LUSC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg11764359 chr7:65958608 NA -0.8 -13.13 -0.58 4.83e-32 Aortic root size; LUSC cis rs7312933 0.618 rs12366848 chr12:42682215 A/G cg17420585 chr12:42539391 GXYLT1 -0.33 -6.16 -0.32 2.08e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs12410462 0.581 rs73102371 chr1:227554880 G/A cg04117972 chr1:227635322 NA 0.57 6.36 0.33 6.74e-10 Major depressive disorder; LUSC cis rs7584330 0.518 rs11888077 chr2:238424763 G/A cg16989719 chr2:238392110 NA -0.48 -6.22 -0.32 1.45e-9 Prostate cancer; LUSC cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs5769707 0.616 rs135869 chr22:50008366 T/C cg05373962 chr22:49881684 NA -0.41 -8.43 -0.42 1.05e-15 Monocyte count;Monocyte percentage of white cells; LUSC trans rs800082 1.000 rs800082 chr3:144340205 A/G cg24215973 chr2:240111563 HDAC4 0.42 6.38 0.33 6.07e-10 Smoking behavior; LUSC cis rs7100689 0.784 rs7082102 chr10:82104890 A/C cg01528321 chr10:82214614 TSPAN14 0.93 14.19 0.61 4.26e-36 Post bronchodilator FEV1; LUSC cis rs2281845 0.929 rs2057579 chr1:201099275 T/C cg17810781 chr1:201082982 CACNA1S 0.35 6.45 0.33 3.94e-10 Permanent tooth development; LUSC cis rs6701037 0.875 rs6929 chr1:175126721 A/G cg17845761 chr1:175162550 KIAA0040 -0.29 -5.7 -0.3 2.66e-8 Alcohol dependence; LUSC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.27 0.37 2.54e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.19 0.37 4.36e-12 Cognitive ability; LUSC cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg06784218 chr1:46089804 CCDC17 0.36 6.12 0.32 2.67e-9 Platelet count; LUSC cis rs9811920 0.965 rs9837131 chr3:99854514 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 5.75 0.3 2.02e-8 Axial length; LUSC cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg13256891 chr4:100009986 ADH5 0.45 6.24 0.32 1.3e-9 Alcohol dependence; LUSC cis rs1577917 0.958 rs114467802 chr6:86572350 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.54 -0.34 2.32e-10 Response to antipsychotic treatment; LUSC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg16545954 chr1:2118288 C1orf86 0.35 6.72 0.34 8.08e-11 Height; LUSC cis rs6456156 0.774 rs9347175 chr6:167527644 A/T cg07741184 chr6:167504864 NA -0.37 -6.51 -0.34 2.78e-10 Primary biliary cholangitis; LUSC cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg09307838 chr4:120376055 NA 0.76 10.88 0.51 8.71e-24 Corneal astigmatism; LUSC cis rs225245 0.791 rs4796103 chr17:34025182 A/G cg05299278 chr17:33885742 SLFN14 0.29 6.44 0.33 4.09e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs10911232 0.507 rs10797815 chr1:182996827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs12477438 0.666 rs10179910 chr2:99658503 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.37 -0.49 5.15e-22 Chronic sinus infection; LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs7202877 0.561 rs8050662 chr16:75360734 A/G cg04384234 chr16:75411784 CFDP1 0.64 9.32 0.45 1.57e-18 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg03188948 chr7:1209495 NA 0.67 7.1 0.36 7.77e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8180040 0.726 rs4682837 chr3:46999707 C/T cg16586182 chr3:47516702 SCAP -0.51 -8.03 -0.4 1.73e-14 Colorectal cancer; LUSC trans rs3733585 0.781 rs6449183 chr4:9970691 C/A cg26043149 chr18:55253948 FECH -0.46 -7.04 -0.36 1.09e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs2727020 0.754 rs10839226 chr11:49150883 C/G cg03929089 chr4:120376271 NA -0.48 -6.55 -0.34 2.22e-10 Coronary artery disease; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13012494 chr21:47604986 C21orf56 -0.44 -6.59 -0.34 1.7e-10 Testicular germ cell tumor; LUSC cis rs1014246 0.807 rs12784789 chr10:118473593 A/T cg14919929 chr10:118506882 NA 0.4 6.03 0.31 4.27e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg21782813 chr7:2030301 MAD1L1 0.37 6.03 0.31 4.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs11112613 0.762 rs17037312 chr12:105950085 C/T cg03607813 chr12:105948248 NA 0.82 12.44 0.56 1.96e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs17685 0.753 rs6953665 chr7:75769049 C/T cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg02450064 chr17:40260053 DHX58 0.44 6.25 0.32 1.29e-9 Fibrinogen levels; LUSC cis rs11122272 0.735 rs2790889 chr1:231520240 C/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs11992186 0.597 rs11781841 chr8:8595263 T/A cg15556689 chr8:8085844 FLJ10661 -0.44 -6.16 -0.32 2.09e-9 Neuroticism; LUSC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.47 0.5 2.18e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg02018176 chr4:1364513 KIAA1530 0.56 9.69 0.47 1.03e-19 Obesity-related traits; LUSC cis rs6733011 0.500 rs10182043 chr2:99417433 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.25 -0.32 1.29e-9 Bipolar disorder; LUSC cis rs1003719 0.667 rs73201942 chr21:38475164 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 9.24 0.45 2.96e-18 Eye color traits; LUSC cis rs4722404 0.592 rs7791687 chr7:3119643 G/A cg19214707 chr7:3157722 NA -0.4 -6.66 -0.34 1.14e-10 Atopic dermatitis; LUSC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.06 16.04 0.66 2.45e-43 Age-related macular degeneration (geographic atrophy); LUSC cis rs4343996 0.902 rs4722710 chr7:3388254 C/A cg21248987 chr7:3385318 SDK1 -0.42 -7.27 -0.37 2.57e-12 Motion sickness; LUSC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg11812906 chr14:75593930 NEK9 -0.67 -11.46 -0.53 7.07e-26 Height; LUSC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg24060327 chr5:131705240 SLC22A5 0.39 6.51 0.34 2.72e-10 Blood metabolite levels; LUSC cis rs1395 0.922 rs13404327 chr2:27519153 G/T cg23587288 chr2:27483067 SLC30A3 -0.3 -5.81 -0.3 1.49e-8 Blood metabolite levels; LUSC cis rs4631830 0.747 rs745180 chr10:51504493 A/C cg16070123 chr10:51489643 NA 0.55 9.1 0.45 8.17e-18 Prostate-specific antigen levels; LUSC cis rs9987353 0.589 rs1053036 chr8:9060077 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.61 -0.34 1.53e-10 Recombination measurement; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12974756 chr20:55043516 C20orf43 0.73 6.0 0.31 5.09e-9 Cognitive performance; LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg03188948 chr7:1209495 NA 0.66 7.09 0.36 8.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10489202 0.909 rs61809580 chr1:168091602 A/C cg24449463 chr1:168025552 DCAF6 -0.57 -6.9 -0.35 2.66e-11 Schizophrenia; LUSC cis rs796364 0.755 rs203762 chr2:200905136 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -8.3 -0.41 2.64e-15 Schizophrenia; LUSC cis rs6733011 0.538 rs7565614 chr2:99464834 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.45 -5.92 -0.31 8.04e-9 Bipolar disorder; LUSC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg16414030 chr3:133502952 NA -0.4 -6.05 -0.31 3.89e-9 Iron status biomarkers; LUSC cis rs7086627 0.515 rs7907969 chr10:82153005 T/A cg01528321 chr10:82214614 TSPAN14 0.61 9.07 0.44 1.06e-17 Post bronchodilator FEV1; LUSC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg09699651 chr6:150184138 LRP11 0.38 5.75 0.3 2.07e-8 Lung cancer; LUSC cis rs1160297 0.609 rs4525730 chr2:53097497 C/T cg07782112 chr2:53107842 NA 0.43 6.96 0.36 1.83e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg13010199 chr12:38710504 ALG10B -0.58 -9.15 -0.45 5.64e-18 Bladder cancer; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg13047869 chr3:10149882 C3orf24 0.65 9.34 0.46 1.36e-18 Alzheimer's disease; LUSC cis rs6681460 1.000 rs1325263 chr1:67129791 C/A cg02459107 chr1:67143332 SGIP1 0.48 9.01 0.44 1.56e-17 Presence of antiphospholipid antibodies; LUSC cis rs12410462 1.000 rs1587158 chr1:227658753 G/A cg23173402 chr1:227635558 NA -0.46 -5.73 -0.3 2.2e-8 Major depressive disorder; LUSC cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg25817165 chr18:72167213 CNDP2 -0.74 -8.97 -0.44 2.22e-17 Refractive error; LUSC cis rs8062405 1.000 rs8061590 chr16:28895130 A/G cg09754948 chr16:28834200 ATXN2L 0.42 6.02 0.31 4.72e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9486719 1.000 rs926276 chr6:96868735 C/T cg06623918 chr6:96969491 KIAA0776 0.76 9.67 0.47 1.14e-19 Migraine;Coronary artery disease; LUSC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg24296786 chr1:45957014 TESK2 0.53 8.22 0.41 4.65e-15 High light scatter reticulocyte count; LUSC cis rs9399135 0.773 rs1331308 chr6:135405122 G/T cg24558204 chr6:135376177 HBS1L -0.47 -6.99 -0.36 1.48e-11 Red blood cell count; LUSC cis rs7615316 0.779 rs7652687 chr3:142123276 G/A cg16271453 chr3:142027066 XRN1 -0.41 -7.23 -0.37 3.29e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11690935 0.921 rs4668414 chr2:172704291 A/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.54 -0.62 1.88e-37 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00873521 chr9:95056130 IARS;SNORA84 0.41 6.02 0.31 4.6e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7180079 0.620 rs11635211 chr15:65016298 A/C cg08069370 chr15:64387884 SNX1 0.53 5.94 0.31 7.07e-9 Monocyte count; LUSC cis rs17095355 0.818 rs12573187 chr10:111856077 G/A cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.51 -0.34 2.76e-10 Biliary atresia; LUSC cis rs6121246 0.542 rs76513665 chr20:30450232 T/C cg13852791 chr20:30311386 BCL2L1 0.68 6.51 0.34 2.79e-10 Mean corpuscular hemoglobin; LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg22963979 chr7:1858916 MAD1L1 -0.7 -11.51 -0.53 4.69e-26 Bipolar disorder and schizophrenia; LUSC cis rs3733585 0.699 rs60045583 chr4:9971950 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.02 -0.44 1.49e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg00343986 chr7:65444356 GUSB -0.44 -6.79 -0.35 5.23e-11 Aortic root size; LUSC trans rs61931739 0.500 rs10772160 chr12:34456848 G/A cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.87e-34 Morning vs. evening chronotype; LUSC cis rs2346177 0.875 rs2346178 chr2:46647061 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.56 -8.77 -0.43 9.35e-17 HDL cholesterol; LUSC cis rs6500602 0.647 rs1641868 chr16:4594503 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.5 6.7 0.34 8.74e-11 Schizophrenia; LUSC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg10523679 chr1:76189770 ACADM 0.9 16.2 0.66 5.81e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9355610 0.892 rs2247314 chr6:167370230 T/C cg25258033 chr6:167368657 RNASET2 -0.36 -5.77 -0.3 1.8e-8 Graves' disease; LUSC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg11247378 chr22:39784982 NA 0.64 13.12 0.58 5.46e-32 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg07701084 chr6:150067640 NUP43 0.47 7.01 0.36 1.32e-11 Testicular germ cell tumor; LUSC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg20135002 chr11:47629003 NA -0.5 -7.76 -0.39 1.05e-13 Subjective well-being; LUSC cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.01 0.36 1.33e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11644478 chr21:40555479 PSMG1 -0.66 -10.34 -0.49 6.42e-22 Menarche (age at onset); LUSC cis rs7617773 0.694 rs13099560 chr3:48204768 C/T cg11946769 chr3:48343235 NME6 -0.71 -11.13 -0.52 1.07e-24 Coronary artery disease; LUSC cis rs7582180 0.614 rs4850931 chr2:101005145 C/T cg12002119 chr2:101014098 CHST10 0.35 5.96 0.31 6.58e-9 Intelligence (multi-trait analysis); LUSC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg06112835 chr11:68658793 MRPL21 0.49 7.66 0.39 2.1e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7587476 0.784 rs13008641 chr2:215698033 T/C cg04004882 chr2:215674386 BARD1 0.49 6.44 0.33 4.06e-10 Neuroblastoma; LUSC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.44 -7.19 -0.37 4.24e-12 IgG glycosylation; LUSC cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg01503450 chr10:980765 NA -0.4 -5.87 -0.31 1.04e-8 Eosinophil percentage of granulocytes; LUSC cis rs10781543 0.839 rs7863766 chr9:139381314 T/G cg14169450 chr9:139327907 INPP5E 0.46 8.22 0.41 4.61e-15 Monocyte percentage of white cells; LUSC cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg13010199 chr12:38710504 ALG10B -0.64 -10.94 -0.51 5.0600000000000004e-24 Heart rate; LUSC cis rs12618769 0.597 rs4851133 chr2:99050519 T/C cg10123293 chr2:99228465 UNC50 0.45 7.64 0.39 2.31e-13 Bipolar disorder; LUSC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg06505273 chr16:24850292 NA 0.41 5.81 0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs7819412 0.875 rs11250121 chr8:11060311 A/C cg21775007 chr8:11205619 TDH -0.56 -8.05 -0.4 1.49e-14 Triglycerides; LUSC cis rs9325144 0.560 rs7304568 chr12:38632408 G/A cg13010199 chr12:38710504 ALG10B -0.53 -8.15 -0.41 7.26e-15 Morning vs. evening chronotype; LUSC cis rs9326248 0.581 rs10790167 chr11:116800943 T/C cg26566898 chr11:117069891 TAGLN 0.38 7.18 0.37 4.57e-12 Blood protein levels; LUSC trans rs61931739 0.500 rs7979240 chr12:34509026 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.52 0.65 2.9e-41 Morning vs. evening chronotype; LUSC cis rs9788721 0.967 rs2036527 chr15:78851615 G/A cg06917634 chr15:78832804 PSMA4 -0.45 -6.06 -0.31 3.77e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg16031515 chr1:205743344 RAB7L1 -0.28 -6.11 -0.32 2.73e-9 Menarche (age at onset); LUSC trans rs17767294 0.708 rs72848755 chr6:27878553 T/C cg19566879 chr6:16334128 ATXN1 0.66 5.98 0.31 5.71e-9 Parkinson's disease; LUSC cis rs2692947 0.644 rs1168975 chr2:96814075 G/A cg22654517 chr2:96458247 NA 0.32 5.88 0.31 9.97e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11039100 1.000 rs12361754 chr11:5828027 T/C cg13902645 chr11:5959945 NA -0.52 -5.84 -0.3 1.25e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg04117972 chr1:227635322 NA 0.61 6.88 0.35 2.9e-11 Major depressive disorder; LUSC cis rs6121246 0.697 rs6060446 chr20:30231637 T/C cg18721089 chr20:30220636 NA -0.42 -6.94 -0.35 2.05e-11 Mean corpuscular hemoglobin; LUSC cis rs9902453 0.933 rs9898353 chr17:28451865 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.87 0.4 4.86e-14 Coffee consumption (cups per day); LUSC cis rs6424115 1.000 rs6424115 chr1:24153231 A/G cg15997130 chr1:24165203 NA -0.56 -9.07 -0.44 1.06e-17 Immature fraction of reticulocytes; LUSC cis rs11792861 0.851 rs17552292 chr9:111891954 C/T cg05043794 chr9:111880884 C9orf5 -0.36 -7.76 -0.39 1.06e-13 Menarche (age at onset); LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg14092988 chr3:52407081 DNAH1 0.33 6.42 0.33 4.7e-10 Bipolar disorder; LUSC cis rs2835872 0.727 rs2835894 chr21:39066042 A/G cg20424643 chr21:39039972 KCNJ6 0.42 6.55 0.34 2.18e-10 Electroencephalographic traits in alcoholism; LUSC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg23583168 chr7:148888333 NA -0.8 -13.05 -0.58 1.01e-31 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.7 9.64 0.47 1.44e-19 Chronic sinus infection; LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg16325326 chr1:53192061 ZYG11B 0.81 14.3 0.62 1.63e-36 Monocyte count; LUSC cis rs2835872 0.726 rs1515056 chr21:39082585 C/G cg20424643 chr21:39039972 KCNJ6 0.45 6.74 0.35 7.03e-11 Electroencephalographic traits in alcoholism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18156033 chr2:158485580 ACVR1C 0.46 6.3 0.33 9.35e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6494488 0.500 rs72742997 chr15:65009527 G/A cg08069370 chr15:64387884 SNX1 -0.66 -5.77 -0.3 1.76e-8 Coronary artery disease; LUSC cis rs11098499 0.863 rs34868248 chr4:120442430 A/G cg09307838 chr4:120376055 NA 0.73 10.28 0.49 9.89e-22 Corneal astigmatism; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.76 0.39 1.05e-13 Prudent dietary pattern; LUSC cis rs13031619 1.000 rs6724730 chr2:3697987 G/C cg10645314 chr2:3704589 ALLC 0.49 7.85 0.39 5.9e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.18 -0.72 8.14e-56 Height; LUSC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg19077165 chr18:44547161 KATNAL2 -0.38 -5.75 -0.3 1.98e-8 Personality dimensions; LUSC cis rs4704187 0.687 rs11950665 chr5:74423339 A/G cg03227963 chr5:74354835 NA 0.31 6.62 0.34 1.45e-10 Response to amphetamines; LUSC trans rs11992162 0.967 rs10112888 chr8:11830208 G/C cg27411982 chr8:10470053 RP1L1 0.49 7.64 0.39 2.24e-13 Monocyte count; LUSC cis rs7267979 1.000 rs6115168 chr20:25372891 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.76 -0.8 1.38e-77 Height; LUSC cis rs2637266 0.783 rs2583070 chr10:78518555 C/T cg18941641 chr10:78392320 NA 0.4 7.23 0.37 3.31e-12 Pulmonary function; LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg27284194 chr4:1044797 NA -0.36 -5.83 -0.3 1.29e-8 Obesity-related traits; LUSC cis rs6977660 0.714 rs17141884 chr7:19790280 A/G cg05791153 chr7:19748676 TWISTNB -0.76 -8.45 -0.42 8.93e-16 Thyroid stimulating hormone; LUSC cis rs4843747 0.749 rs13333619 chr16:88072076 C/T cg17633681 chr16:88106987 BANP 0.5 9.26 0.45 2.51e-18 Menopause (age at onset); LUSC cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg00071950 chr4:10020882 SLC2A9 -0.52 -8.74 -0.43 1.15e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.79 0.47 4.44e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg08971769 chr10:75258327 USP54 -0.39 -6.17 -0.32 1.97e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs4332037 0.950 rs56403963 chr7:1946130 C/G cg23422044 chr7:1970798 MAD1L1 -0.65 -7.32 -0.37 1.84e-12 Bipolar disorder; LUSC trans rs7726839 0.561 rs72703046 chr5:580129 T/C cg25482853 chr8:67687455 SGK3 1.04 15.54 0.65 2.23e-41 Obesity-related traits; LUSC cis rs950776 0.518 rs4886572 chr15:78837452 A/G cg06917634 chr15:78832804 PSMA4 -0.81 -14.26 -0.62 2.34e-36 Sudden cardiac arrest; LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg12432903 chr7:1882776 MAD1L1 -0.51 -8.53 -0.42 5.09e-16 Bipolar disorder and schizophrenia; LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg24110177 chr3:50126178 RBM5 -0.61 -10.5 -0.5 1.74e-22 Body mass index; LUSC cis rs1113500 0.862 rs2336128 chr1:108640739 G/T cg06207961 chr1:108661230 NA 0.41 7.56 0.38 3.86e-13 Growth-regulated protein alpha levels; LUSC cis rs7336332 0.598 rs75439483 chr13:28010512 A/G cg22138327 chr13:27999177 GTF3A 0.8 10.02 0.48 7.6e-21 Weight; LUSC trans rs60843830 0.623 rs55932737 chr2:107543 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.52 8.06 0.4 1.36e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs3857536 0.740 rs7756519 chr6:66892275 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg11645453 chr3:52864694 ITIH4 0.34 7.77 0.39 9.56e-14 Intelligence (multi-trait analysis); LUSC cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.7 -0.3 2.67e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.35 6.15 0.32 2.23e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7937682 0.663 rs3867466 chr11:111668256 A/C cg09085632 chr11:111637200 PPP2R1B 0.94 12.79 0.57 9.52e-31 Primary sclerosing cholangitis; LUSC cis rs4363385 1.000 rs310124 chr1:153020275 C/T cg00922841 chr1:152955080 SPRR1A -0.48 -8.11 -0.41 9.75e-15 Inflammatory skin disease; LUSC cis rs9486715 1.000 rs6899647 chr6:97065661 A/G cg06623918 chr6:96969491 KIAA0776 -0.86 -14.49 -0.62 2.99e-37 Headache; LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.9 -0.4 4.05e-14 Blood metabolite levels; LUSC cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 8.16e-15 Axial length; LUSC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg16414030 chr3:133502952 NA 0.38 6.19 0.32 1.8e-9 Iron status biomarkers; LUSC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg24110177 chr3:50126178 RBM5 0.58 9.56 0.46 2.63e-19 Intelligence (multi-trait analysis); LUSC trans rs34984545 1.000 rs10032067 chr4:145978910 G/T cg27525185 chr19:36869526 NA -0.67 -6.04 -0.31 4.08e-9 Angiotensin-converting enzyme inhibitor intolerance; LUSC cis rs340630 0.967 rs13126334 chr4:87909890 A/G cg10685359 chr4:87814065 C4orf36 0.33 5.81 0.3 1.49e-8 Systemic lupus erythematosus; LUSC cis rs472402 0.623 rs7727273 chr5:6635933 A/C cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.48 -7.17 -0.37 4.75e-12 Response to amphetamines; LUSC trans rs11039798 1.000 rs7928243 chr11:48589192 A/T cg15704280 chr7:45808275 SEPT13 0.72 6.82 0.35 4.21e-11 Axial length; LUSC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg10523679 chr1:76189770 ACADM 0.87 14.11 0.61 8.39e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9323205 0.911 rs12587611 chr14:51641399 C/T cg23942311 chr14:51606299 NA -0.42 -8.91 -0.44 3.42e-17 Cancer; LUSC cis rs7264396 0.573 rs58355182 chr20:34075687 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.32 -0.33 8.54e-10 Total cholesterol levels; LUSC cis rs62400317 0.859 rs62436778 chr6:45120666 A/G cg20913747 chr6:44695427 NA -0.46 -7.49 -0.38 6.35e-13 Total body bone mineral density; LUSC trans rs17112190 1.000 rs17112175 chr10:98616993 G/T cg25121125 chr3:64674314 ADAMTS9 0.68 5.96 0.31 6.57e-9 Multiple myeloma (IgH translocation); LUSC cis rs7568458 0.905 rs59877521 chr2:85759494 C/T cg02493740 chr2:85810744 VAMP5 -0.34 -6.06 -0.31 3.71e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3772130 0.583 rs12695415 chr3:121398853 C/T cg20356878 chr3:121714668 ILDR1 0.55 8.91 0.44 3.42e-17 Cognitive performance; LUSC trans rs12579753 0.912 rs4417392 chr12:82158722 C/A cg07923666 chr12:49932857 KCNH3 -0.52 -6.75 -0.35 6.56e-11 Resting heart rate; LUSC cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg25208724 chr1:156163844 SLC25A44 1.05 17.93 0.7 8.17e-51 Testicular germ cell tumor; LUSC cis rs17539620 0.534 rs6557363 chr6:154827813 A/G cg20019720 chr6:154832845 CNKSR3 0.58 8.55 0.42 4.39e-16 Lipoprotein (a) levels; LUSC cis rs7584330 0.554 rs79020383 chr2:238425834 G/A cg16989719 chr2:238392110 NA -0.45 -6.48 -0.33 3.28e-10 Prostate cancer; LUSC cis rs78456975 1.000 rs13397299 chr2:1564222 A/C cg01028140 chr2:1542097 TPO -0.61 -8.28 -0.41 2.9e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC trans rs6924906 0.655 rs77382925 chr6:82237514 A/G cg15052890 chr17:4636830 MED11;CXCL16 -0.58 -6.12 -0.32 2.57e-9 Blood pressure; LUSC trans rs747782 0.536 rs10838873 chr11:48337765 T/C cg15704280 chr7:45808275 SEPT13 0.61 5.97 0.31 5.98e-9 Intraocular pressure; LUSC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg01849466 chr14:104193079 ZFYVE21 -0.53 -7.74 -0.39 1.23e-13 Reticulocyte count; LUSC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg08470875 chr2:26401718 FAM59B -0.68 -9.08 -0.45 9.51e-18 Gut microbiome composition (summer); LUSC cis rs1507153 0.775 rs7763429 chr6:79350769 G/A cg05283184 chr6:79620031 NA -0.42 -7.33 -0.37 1.76e-12 Sjögren's syndrome; LUSC cis rs870825 0.616 rs4623060 chr4:185642943 A/G cg04058563 chr4:185651563 MLF1IP 0.86 13.27 0.59 1.42e-32 Blood protein levels; LUSC cis rs7267979 0.933 rs2424708 chr20:25281398 C/T cg03522245 chr20:25566470 NINL 0.36 5.89 0.31 9.52e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6542838 0.611 rs13006398 chr2:99522323 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.01 -0.31 4.94e-9 Fear of minor pain; LUSC trans rs1994135 0.617 rs12821909 chr12:33723466 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.03 0.48 7.38e-21 Resting heart rate; LUSC cis rs7923609 1.000 rs4310508 chr10:65138573 A/G cg01631684 chr10:65280961 REEP3 -0.38 -5.89 -0.31 9.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.78 0.3 1.74e-8 Menopause (age at onset); LUSC trans rs45509595 0.841 rs401754 chr6:27782538 T/A cg06606381 chr12:133084897 FBRSL1 -0.74 -7.4 -0.38 1.1e-12 Breast cancer; LUSC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 9.91e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.08 0.55 3.89e-28 Menopause (age at onset); LUSC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg00310523 chr12:86230176 RASSF9 0.47 8.69 0.43 1.7e-16 Major depressive disorder; LUSC cis rs7586879 0.828 rs10195271 chr2:25108650 A/C cg01884057 chr2:25150051 NA -0.41 -8.6 -0.43 3.06e-16 Body mass index; LUSC cis rs7917772 0.582 rs4917975 chr10:104358407 C/G cg05855489 chr10:104503620 C10orf26 -0.49 -7.42 -0.38 9.5e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg21856205 chr7:94953877 PON1 0.36 5.84 0.3 1.23e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg00815214 chr21:47717953 NA 0.36 5.83 0.3 1.33e-8 Testicular germ cell tumor; LUSC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.2 -0.32 1.68e-9 Total body bone mineral density; LUSC cis rs7917772 0.582 rs10748826 chr10:104354804 T/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.26e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25106220 chr2:113522384 CKAP2L 0.45 6.05 0.31 3.99e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.64 0.43 2.32e-16 Height; LUSC cis rs1957429 0.808 rs4902327 chr14:65344803 C/T cg23373153 chr14:65346875 NA 0.92 10.13 0.48 3.23e-21 Pediatric areal bone mineral density (radius); LUSC cis rs12190007 0.508 rs6605537 chr6:169730781 G/A cg16388071 chr6:169726476 NA 0.39 6.34 0.33 7.31e-10 Obesity-related traits; LUSC cis rs7432375 0.610 rs4420814 chr3:136513282 T/C cg15507776 chr3:136538369 TMEM22 0.44 7.37 0.37 1.37e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs9611565 0.921 rs5758297 chr22:41720697 A/G cg03806693 chr22:41940476 POLR3H -0.7 -10.32 -0.49 7.64e-22 Vitiligo; LUSC cis rs6977660 0.714 rs1468287 chr7:19784210 T/A cg07541023 chr7:19748670 TWISTNB 0.68 6.79 0.35 5.25e-11 Thyroid stimulating hormone; LUSC cis rs963731 0.649 rs2168044 chr2:39206386 G/A cg04010122 chr2:39346883 SOS1 -0.78 -5.7 -0.3 2.71e-8 Corticobasal degeneration; LUSC cis rs6546886 0.912 rs10164943 chr2:74306056 C/T cg14702570 chr2:74259524 NA -0.3 -5.65 -0.3 3.5e-8 Dialysis-related mortality; LUSC cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 13.82 0.6 1.12e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs35883536 0.513 rs4907910 chr1:101013277 T/A cg06223162 chr1:101003688 GPR88 0.48 8.92 0.44 3.02e-17 Monocyte count; LUSC cis rs2073300 1.000 rs6137960 chr20:23442886 G/A cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6121246 0.909 rs6058450 chr20:30343911 G/A cg13852791 chr20:30311386 BCL2L1 0.9 12.1 0.55 3.45e-28 Mean corpuscular hemoglobin; LUSC cis rs2295359 1.000 rs4655684 chr1:67611772 A/G cg12940439 chr1:67600707 NA -0.36 -5.98 -0.31 5.7e-9 Psoriasis; LUSC cis rs7674212 0.570 rs6810571 chr4:104086787 G/T cg16532752 chr4:104119610 CENPE -0.49 -7.25 -0.37 2.92e-12 Type 2 diabetes; LUSC cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg13010199 chr12:38710504 ALG10B 0.62 9.08 0.44 9.91e-18 Bladder cancer; LUSC cis rs9303401 0.659 rs7225896 chr17:56637337 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.12 0.58 5.22e-32 Cognitive test performance; LUSC cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg06627557 chr7:32535165 LSM5;AVL9 1.08 21.02 0.75 4.3e-63 Cognitive ability; LUSC cis rs79387448 0.745 rs57942521 chr2:103139849 A/G cg09003973 chr2:102972529 NA 0.89 8.69 0.43 1.62e-16 Gut microbiota (bacterial taxa); LUSC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9517320 1.000 rs9645890 chr13:99126637 C/T cg07423050 chr13:99094983 FARP1 0.33 6.32 0.33 8.28e-10 Longevity; LUSC cis rs611744 0.647 rs1584373 chr8:109263399 C/A cg21045802 chr8:109455806 TTC35 0.43 6.63 0.34 1.38e-10 Dupuytren's disease; LUSC cis rs7824557 0.628 rs11782706 chr8:11186215 A/C cg21775007 chr8:11205619 TDH 0.79 13.15 0.58 4.25e-32 Retinal vascular caliber; LUSC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg06238570 chr21:40685208 BRWD1 -0.63 -10.46 -0.5 2.5e-22 Cognitive function; LUSC cis rs977987 0.585 rs62059845 chr16:75430713 A/G cg03315344 chr16:75512273 CHST6 0.48 9.12 0.45 6.97e-18 Dupuytren's disease; LUSC cis rs1178127 0.580 rs1178177 chr7:18799553 C/T cg02370815 chr7:18831390 HDAC9 -0.39 -5.86 -0.31 1.13e-8 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); LUSC cis rs11696845 0.626 rs1111032 chr20:43378770 A/G cg25301532 chr20:43378953 KCNK15 0.35 6.35 0.33 7.23e-10 Obesity-related traits; LUSC cis rs80130819 0.591 rs10875783 chr12:48649736 G/A cg24011408 chr12:48396354 COL2A1 0.46 5.84 0.3 1.22e-8 Prostate cancer; LUSC cis rs7640424 1.000 rs7640424 chr3:107820063 C/T cg09227934 chr3:107805635 CD47 -0.5 -7.65 -0.39 2.18e-13 Body mass index; LUSC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg07700843 chr1:2391317 NA -0.43 -7.85 -0.39 5.55e-14 Schizophrenia; LUSC trans rs10432489 0.708 rs10189224 chr2:181764318 A/C cg25678491 chr13:101327172 TMTC4 -0.82 -6.39 -0.33 5.65e-10 QT interval; LUSC cis rs897984 0.520 rs4889622 chr16:30870957 A/G cg02466173 chr16:30829666 NA 0.55 9.24 0.45 3.06e-18 Dementia with Lewy bodies; LUSC cis rs1568889 1.000 rs35343234 chr11:28034379 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 8.65 0.43 2.23e-16 Bipolar disorder; LUSC cis rs6582630 0.577 rs12312748 chr12:38343326 T/C cg13010199 chr12:38710504 ALG10B -0.42 -6.3 -0.33 9.6e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs13253111 1.000 rs62500888 chr8:28061823 A/G cg26534493 chr8:28060551 NA 0.46 8.81 0.43 7.08e-17 Childhood body mass index; LUSC cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.39 -0.37 1.17e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7089973 0.604 rs2420065 chr10:116583753 A/G cg03647239 chr10:116582469 FAM160B1 0.45 7.21 0.37 3.81e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12618769 0.597 rs17505088 chr2:99149473 C/T cg10123293 chr2:99228465 UNC50 0.46 7.68 0.39 1.77e-13 Bipolar disorder; LUSC cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.75 -13.21 -0.59 2.51e-32 Personality dimensions; LUSC cis rs453301 0.657 rs36056437 chr8:8792865 T/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.35 -0.46 1.34e-18 Joint mobility (Beighton score); LUSC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg06028605 chr16:24865363 SLC5A11 0.51 9.13 0.45 6.92e-18 Intelligence (multi-trait analysis); LUSC cis rs2798269 0.867 rs60181111 chr13:22097453 A/G cg18095732 chr13:22033692 ZDHHC20 -0.38 -5.77 -0.3 1.86e-8 PR segment; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC cis rs1975974 0.872 rs17052352 chr17:21721972 A/G cg18423549 chr17:21743878 NA -0.52 -8.21 -0.41 5.05e-15 Psoriasis; LUSC trans rs1325195 0.920 rs2816214 chr1:179181546 T/C cg11624085 chr17:8464688 MYH10 0.41 6.62 0.34 1.41e-10 IgE grass sensitization; LUSC cis rs7084921 0.547 rs12780035 chr10:101874844 C/T cg02250046 chr10:101825185 CPN1 -0.35 -6.24 -0.32 1.35e-9 Bone mineral density; LUSC cis rs13006833 0.739 rs291430 chr2:191198727 A/C cg21644426 chr2:191273491 MFSD6 0.42 6.02 0.31 4.52e-9 Urinary metabolites; LUSC cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 8.81 0.43 6.76e-17 Multiple sclerosis; LUSC cis rs41271473 0.526 rs942852 chr1:228730748 A/G cg10167378 chr1:228756711 NA 0.76 9.78 0.47 5.16e-20 Chronic lymphocytic leukemia; LUSC cis rs4629710 0.592 rs11758994 chr6:131582022 A/C cg12606694 chr6:131520996 AKAP7 0.64 9.77 0.47 5.44e-20 Multiple myeloma (IgH translocation); LUSC cis rs6582630 0.572 rs7315897 chr12:38449081 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.19 -0.41 5.61e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -8.3 -0.41 2.65e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg20503657 chr10:835505 NA 0.78 9.74 0.47 6.96e-20 Eosinophil percentage of granulocytes; LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg25660036 chr4:7070649 GRPEL1 -0.38 -5.69 -0.3 2.75e-8 Monocyte percentage of white cells; LUSC cis rs10751667 0.857 rs6597952 chr11:991109 C/G ch.11.42038R chr11:967971 AP2A2 0.53 7.76 0.39 1.05e-13 Alzheimer's disease (late onset); LUSC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg21573476 chr21:45109991 RRP1B -0.36 -5.79 -0.3 1.6e-8 Mean corpuscular volume; LUSC cis rs1775715 0.707 rs2808094 chr10:32133756 T/C cg26784012 chr10:32216390 ARHGAP12 0.47 7.91 0.4 3.89e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg21782813 chr7:2030301 MAD1L1 0.59 10.47 0.5 2.32e-22 Bipolar disorder and schizophrenia; LUSC trans rs800082 0.507 rs2717379 chr3:144256805 G/A cg24215973 chr2:240111563 HDAC4 0.48 7.39 0.37 1.17e-12 Smoking behavior; LUSC cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.69 -0.39 1.7e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.572 rs139569 chr22:42211141 A/G cg17376030 chr22:41985996 PMM1 0.41 5.67 0.3 3.06e-8 Vitiligo; LUSC cis rs4664308 1.000 rs62175515 chr2:160909524 A/T cg03641300 chr2:160917029 PLA2R1 -0.67 -11.33 -0.53 2.16e-25 Idiopathic membranous nephropathy; LUSC cis rs1865760 1.000 rs6905887 chr6:25912103 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.87 0.35 3.12e-11 Height; LUSC cis rs9837602 0.938 rs17393059 chr3:99761908 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.13 -0.32 2.52e-9 Breast cancer; LUSC cis rs6681460 1.000 rs1445575 chr1:67052164 C/T cg02459107 chr1:67143332 SGIP1 0.46 8.51 0.42 5.83e-16 Presence of antiphospholipid antibodies; LUSC cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg14664628 chr15:75095509 CSK -0.74 -11.95 -0.55 1.17e-27 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg22823121 chr1:150693482 HORMAD1 -0.45 -6.69 -0.34 9.39e-11 Tonsillectomy; LUSC cis rs9905704 0.624 rs4932691 chr17:57094617 T/C cg05425664 chr17:57184151 TRIM37 0.48 7.22 0.37 3.63e-12 Testicular germ cell tumor; LUSC cis rs1775715 0.707 rs1541261 chr10:32179523 G/A cg04359828 chr10:32216031 ARHGAP12 0.41 7.03 0.36 1.2e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg15112475 chr7:1198522 ZFAND2A -0.33 -6.92 -0.35 2.33e-11 Longevity;Endometriosis; LUSC cis rs4561483 0.582 rs3850997 chr16:12043512 G/T cg08843971 chr16:11963173 GSPT1 -0.42 -5.98 -0.31 5.85e-9 Testicular germ cell tumor; LUSC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg18876405 chr7:65276391 NA 0.76 13.57 0.6 1.04e-33 Calcium levels; LUSC cis rs7072216 0.763 rs10883090 chr10:100167236 G/C cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.2 0.85 5.99e-94 Chronic sinus infection; LUSC cis rs7804356 0.906 rs3801830 chr7:26854870 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs3820068 0.580 rs12746773 chr1:16001588 C/T cg13390004 chr1:15929781 NA 0.4 6.62 0.34 1.44e-10 Systolic blood pressure; LUSC trans rs782590 1.000 rs782590 chr2:55843413 C/T cg22328901 chr2:86333256 PTCD3;POLR1A 0.41 5.95 0.31 6.82e-9 Metabolic syndrome; LUSC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg10556349 chr10:835070 NA 0.55 6.21 0.32 1.53e-9 Eosinophil percentage of granulocytes; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.79 0.43 8.13e-17 Prudent dietary pattern; LUSC cis rs1348850 0.757 rs4893969 chr2:178478476 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 5.95 0.31 6.92e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs193541 0.632 rs34714850 chr5:122332695 A/G cg19077854 chr5:122220652 SNX24 -0.39 -8.07 -0.4 1.3e-14 Glucose homeostasis traits; LUSC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.85 0.3 1.2e-8 Tonsillectomy; LUSC trans rs61931739 0.500 rs12146843 chr12:34451738 T/G cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.51e-34 Morning vs. evening chronotype; LUSC cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Alcohol dependence; LUSC cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg13319975 chr6:146136371 FBXO30 -0.47 -7.1 -0.36 7.7e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.909 rs6842762 chr4:120398236 A/T cg09307838 chr4:120376055 NA 0.79 11.59 0.54 2.43e-26 Corneal astigmatism; LUSC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg00864171 chr11:67383662 NA 0.35 6.22 0.32 1.5e-9 Mean corpuscular volume; LUSC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg07256732 chr16:621771 PIGQ -0.36 -6.43 -0.33 4.34e-10 Height; LUSC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg18827107 chr12:86230957 RASSF9 -0.44 -6.58 -0.34 1.78e-10 Major depressive disorder; LUSC cis rs3768617 0.565 rs10752897 chr1:183071024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.76 0.51 2.2e-23 Fuchs's corneal dystrophy; LUSC cis rs7744392 0.546 rs16872293 chr6:35117996 C/G cg06087101 chr6:35551932 FKBP5 0.57 5.87 0.31 1.03e-8 Cataracts in type 2 diabetes; LUSC cis rs12908161 0.959 rs34342559 chr15:85331271 A/G cg12863693 chr15:85201151 NMB 0.4 8.02 0.4 1.79e-14 Schizophrenia; LUSC cis rs877282 0.898 rs11253339 chr10:759640 C/T cg17470449 chr10:769945 NA 0.52 7.39 0.38 1.15e-12 Uric acid levels; LUSC cis rs4423214 1.000 rs7944926 chr11:71165625 A/G cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs2857891 0.817 rs2857885 chr11:6967187 G/A cg14883916 chr11:6947541 ZNF215 0.45 6.03 0.31 4.39e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg05472934 chr7:22766657 IL6 0.46 7.35 0.37 1.51e-12 Lung cancer; LUSC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg15534755 chr11:117069859 TAGLN 0.35 6.15 0.32 2.25e-9 Blood protein levels; LUSC cis rs4499344 0.556 rs259225 chr19:33135458 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.97 14.47 0.62 3.57e-37 Mean platelet volume; LUSC cis rs4363385 0.755 rs1933382 chr1:153003295 G/T cg00922841 chr1:152955080 SPRR1A 0.42 7.27 0.37 2.52e-12 Inflammatory skin disease; LUSC trans rs9944715 0.954 rs12607898 chr18:43802778 A/G cg01718231 chr17:29326311 RNF135 -0.49 -6.75 -0.35 6.63e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7215564 0.908 rs34547024 chr17:78661373 C/G cg23238734 chr17:78661607 RPTOR 0.46 5.93 0.31 7.67e-9 Myopia (pathological); LUSC cis rs752010 0.714 rs7515948 chr1:42079046 T/G cg06885757 chr1:42089581 HIVEP3 0.49 10.43 0.5 3.07e-22 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg04111992 chr7:158790115 NA -0.37 -5.84 -0.3 1.21e-8 Facial morphology (factor 20); LUSC cis rs300703 0.639 rs397719 chr2:204870 T/G cg21211680 chr2:198530 NA 0.66 7.8 0.39 8e-14 Blood protein levels; LUSC cis rs9326248 0.520 rs7127881 chr11:116880798 G/A cg20608306 chr11:116969690 SIK3 0.34 6.33 0.33 7.77e-10 Blood protein levels; LUSC trans rs4332037 0.754 rs62436669 chr7:1926636 G/A cg10840412 chr1:235813424 GNG4 0.67 8.38 0.42 1.48e-15 Bipolar disorder; LUSC trans rs11098499 0.820 rs28394116 chr4:120524283 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.74 0.35 7.17e-11 Corneal astigmatism; LUSC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9532580 0.778 rs61963319 chr13:41244220 A/T cg21288729 chr13:41239152 FOXO1 0.62 9.52 0.46 3.52e-19 Mean corpuscular hemoglobin; LUSC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.48 -6.45 -0.33 3.88e-10 Tonsillectomy; LUSC cis rs9527 0.545 rs7100369 chr10:104956218 C/A cg04362960 chr10:104952993 NT5C2 0.61 9.81 0.47 3.95e-20 Arsenic metabolism; LUSC cis rs2200578 0.732 rs56271621 chr2:99658200 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.64 7.39 0.38 1.15e-12 IgG glycosylation; LUSC cis rs1577917 1.000 rs12215903 chr6:86675028 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.75 -0.35 6.39e-11 Response to antipsychotic treatment; LUSC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg04287289 chr16:89883240 FANCA -0.48 -7.56 -0.38 3.9e-13 Vitiligo; LUSC cis rs3803170 0.513 rs7302763 chr12:111827569 C/T cg10833066 chr12:111807467 FAM109A 0.38 6.97 0.36 1.68e-11 Mean corpuscular hemoglobin; LUSC cis rs2404602 0.692 rs4442773 chr15:77031633 T/C cg23625390 chr15:77176239 SCAPER 0.46 6.88 0.35 2.96e-11 Blood metabolite levels; LUSC cis rs6967385 0.580 rs3902479 chr7:12329328 T/C cg06484146 chr7:12443880 VWDE 0.41 6.48 0.33 3.24e-10 Response to taxane treatment (placlitaxel); LUSC trans rs561341 0.941 rs736678 chr17:30347423 G/T cg27661571 chr11:113659931 NA -0.69 -7.81 -0.39 7.56e-14 Hip circumference adjusted for BMI; LUSC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg03709012 chr19:19516395 GATAD2A -0.82 -13.22 -0.59 2.14e-32 Tonsillectomy; LUSC cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.15 0.58 4.1e-32 Chronic sinus infection; LUSC cis rs79976124 0.837 rs11751145 chr6:66642039 T/C cg07460842 chr6:66804631 NA 0.68 8.53 0.42 5.16e-16 Type 2 diabetes; LUSC cis rs6424115 0.830 rs2229584 chr1:24200969 T/C cg10978503 chr1:24200527 CNR2 0.54 13.3 0.59 1.11e-32 Immature fraction of reticulocytes; LUSC cis rs6582630 0.572 rs1969363 chr12:38514872 A/G cg26384229 chr12:38710491 ALG10B 0.66 10.4 0.49 3.9e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs4499344 0.622 rs2903752 chr19:33049943 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 9.78 0.47 4.83e-20 Mean platelet volume; LUSC cis rs7633770 0.786 rs4234464 chr3:46679675 C/T cg11219411 chr3:46661640 NA -0.36 -7.61 -0.38 2.91e-13 Coronary artery disease; LUSC cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.52e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg12463550 chr7:65579703 CRCP 0.51 7.43 0.38 9.07e-13 Aortic root size; LUSC cis rs208520 0.874 rs208485 chr6:66925654 T/C cg07460842 chr6:66804631 NA -1.01 -14.4 -0.62 6.88e-37 Exhaled nitric oxide output; LUSC cis rs11758351 0.715 rs75390741 chr6:26209784 A/T cg01420254 chr6:26195488 NA 0.65 6.99 0.36 1.54e-11 Gout;Renal underexcretion gout; LUSC cis rs4148883 0.504 rs2000864 chr4:100123776 A/C cg12011299 chr4:100065546 ADH4 0.41 6.82 0.35 4.21e-11 Alcohol dependence; LUSC cis rs11195062 0.805 rs10884942 chr10:112016926 A/G cg00817464 chr10:111662876 XPNPEP1 -0.4 -5.92 -0.31 8e-9 Multiple myeloma; LUSC cis rs2898681 0.618 rs7677726 chr4:53739262 A/G cg00791764 chr4:53727839 RASL11B -0.46 -6.06 -0.31 3.67e-9 Optic nerve measurement (cup area); LUSC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg21518248 chr2:162101506 NA 0.45 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs16854884 0.586 rs13081286 chr3:143723757 A/T cg06585982 chr3:143692056 C3orf58 0.51 8.14 0.41 7.78e-15 Economic and political preferences (feminism/equality); LUSC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.98 -0.31 5.72e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05969021 chr1:23886005 ID3 0.7 6.26 0.32 1.21e-9 Cognitive performance; LUSC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg00033643 chr7:134001901 SLC35B4 0.46 7.28 0.37 2.45e-12 Mean platelet volume; LUSC trans rs747782 0.582 rs7949865 chr11:48346202 A/C cg15704280 chr7:45808275 SEPT13 -0.72 -6.85 -0.35 3.66e-11 Intraocular pressure; LUSC cis rs6982240 0.514 rs72681579 chr8:142263074 G/A cg00131261 chr8:142287264 NA -0.36 -6.07 -0.32 3.53e-9 Tonsillectomy; LUSC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -16.88 -0.68 1.16e-46 Primary sclerosing cholangitis; LUSC cis rs12421382 0.659 rs2165137 chr11:109381995 G/T cg11473876 chr11:109292803 C11orf87 0.41 6.58 0.34 1.79e-10 Schizophrenia; LUSC trans rs8022206 0.659 rs72725119 chr14:68329020 G/A cg15809352 chr2:121748218 GLI2 0.45 6.58 0.34 1.8e-10 Platelet count;Mean platelet volume; LUSC cis rs2050392 0.517 rs656600 chr10:30765654 G/A cg18806716 chr10:30721971 MAP3K8 -0.6 -9.43 -0.46 7.21e-19 Inflammatory bowel disease; LUSC cis rs7312933 0.501 rs3810793 chr12:42729407 C/T cg01256987 chr12:42539512 GXYLT1 -0.37 -6.71 -0.34 8.58e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1728785 0.818 rs1728772 chr16:68584526 C/T cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs2412459 0.536 rs7173301 chr15:40269843 C/T cg22077389 chr15:40226273 EIF2AK4 0.52 6.3 0.33 9.41e-10 Response to haloperidol in psychosis; LUSC cis rs68170813 0.559 rs6949961 chr7:106850755 G/T cg02696742 chr7:106810147 HBP1 0.62 9.3 0.45 1.94e-18 Coronary artery disease; LUSC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg13647721 chr17:30228624 UTP6 0.61 6.0 0.31 5.23e-9 Hip circumference adjusted for BMI; LUSC cis rs11711311 0.869 rs12493635 chr3:113373019 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.92 -0.31 7.85e-9 IgG glycosylation; LUSC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg06484146 chr7:12443880 VWDE -0.74 -7.61 -0.38 2.77e-13 Coronary artery disease; LUSC cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg23093090 chr10:104574429 C10orf26 -0.43 -7.66 -0.39 2.09e-13 Arsenic metabolism; LUSC cis rs1662342 1.000 rs1662345 chr18:3251743 A/G cg00760847 chr18:3262519 MYL12B -0.58 -5.68 -0.3 2.97e-8 QRS duration; LUSC trans rs10435719 0.899 rs9329251 chr8:11793606 G/A cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.61e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg21770322 chr7:97807741 LMTK2 0.45 7.59 0.38 3.1400000000000003e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs13191362 0.573 rs9365499 chr6:163271833 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.52 7.34 0.37 1.65e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.654 rs1129654 chr1:152958238 A/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.78 -0.39 9.11e-14 Inflammatory skin disease; LUSC cis rs10871290 0.881 rs3863439 chr16:74470644 T/C cg01733217 chr16:74700730 RFWD3 -0.6 -8.61 -0.43 2.89e-16 Breast cancer; LUSC cis rs3858526 0.834 rs7125244 chr11:5980359 T/C cg05234568 chr11:5960015 NA -0.64 -9.08 -0.44 1e-17 DNA methylation (variation); LUSC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg06634786 chr22:41940651 POLR3H 0.5 6.04 0.31 4.07e-9 Vitiligo; LUSC cis rs11098499 0.754 rs7672778 chr4:120248585 A/G cg24375607 chr4:120327624 NA 0.76 12.2 0.56 1.5e-28 Corneal astigmatism; LUSC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg00074818 chr8:8560427 CLDN23 0.58 9.9 0.48 2.04e-20 Obesity-related traits; LUSC cis rs738322 0.935 rs133014 chr22:38571087 T/G cg25457927 chr22:38595422 NA -0.42 -8.92 -0.44 3.05e-17 Cutaneous nevi; LUSC trans rs9393777 0.720 rs56401801 chr6:27301512 T/A cg06606381 chr12:133084897 FBRSL1 -0.97 -8.61 -0.43 2.92e-16 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg13615516 chr5:77269221 NA 0.39 6.62 0.34 1.39e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs929354 0.742 rs2006844 chr7:157002851 G/A cg17757837 chr7:157058334 UBE3C 0.82 13.21 0.59 2.34e-32 Body mass index; LUSC cis rs11785400 0.762 rs9694556 chr8:143727841 A/G cg10596483 chr8:143751796 JRK 0.52 7.41 0.38 1.04e-12 Schizophrenia; LUSC cis rs240764 0.658 rs4840148 chr6:101182500 G/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.54e-10 Neuroticism; LUSC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg16325326 chr1:53192061 ZYG11B 0.92 17.22 0.69 5.28e-48 Monocyte count; LUSC cis rs73206853 0.841 rs4131851 chr12:110812345 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09270044 chr1:186344798 TPR;C1orf27;MIR548F1 -0.41 -6.29 -0.33 1.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1493916 1.000 rs990882 chr18:31398180 T/G cg27147174 chr7:100797783 AP1S1 -0.64 -10.25 -0.49 1.33e-21 Life satisfaction; LUSC cis rs7267979 1.000 rs6076339 chr20:25348712 T/C cg08601574 chr20:25228251 PYGB -0.4 -6.26 -0.32 1.17e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1801251 1.000 rs9653383 chr2:233670380 A/C cg25237894 chr2:233734115 C2orf82 -0.36 -6.56 -0.34 2.06e-10 Coronary artery disease; LUSC cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg07828340 chr4:882639 GAK 1.08 11.67 0.54 1.28e-26 Intelligence (multi-trait analysis); LUSC cis rs2816062 0.710 rs2816052 chr1:18895536 T/C cg18795169 chr1:18902165 NA -1.01 -24.4 -0.8 3.36e-76 Urate levels in lean individuals; LUSC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.7 0.3 2.6e-8 Self-reported allergy; LUSC trans rs12579753 0.913 rs12579018 chr12:82231943 T/C cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg13902645 chr11:5959945 NA -0.6 -8.36 -0.42 1.71e-15 DNA methylation (variation); LUSC cis rs7904368 0.806 rs45495501 chr10:16861476 G/A cg23933602 chr10:16859644 RSU1 0.54 6.24 0.32 1.29e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg05868516 chr6:26286170 HIST1H4H 0.36 5.99 0.31 5.38e-9 Educational attainment; LUSC cis rs7937890 1.000 rs2970335 chr11:14325401 A/C cg02886208 chr11:14281011 SPON1 -0.33 -5.7 -0.3 2.58e-8 Mitochondrial DNA levels; LUSC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg07414643 chr4:187882934 NA 0.54 9.87 0.48 2.56e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs36093844 0.800 rs17817326 chr11:85595213 C/T cg25872744 chr11:85566296 CCDC83 -0.46 -6.04 -0.31 4.16e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs7598759 0.588 rs6737291 chr2:232329559 T/C cg19187155 chr2:232395269 NMUR1 0.49 7.2 0.37 3.96e-12 Noise-induced hearing loss; LUSC cis rs7829975 0.686 rs907180 chr8:8702827 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.93 0.35 2.21e-11 Mood instability; LUSC cis rs921968 0.619 rs1554623 chr2:219606177 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.0 -0.48 9.34e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg24692254 chr21:30365293 RNF160 -0.76 -13.42 -0.59 3.9e-33 Dental caries; LUSC trans rs10851478 0.872 rs8032688 chr15:49929664 A/G cg23074453 chr15:44487924 FRMD5 -0.33 -6.08 -0.32 3.26e-9 Oral cavity cancer; LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs9814567 1.000 rs6763088 chr3:134254989 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg22166914 chr1:53195759 ZYG11B 0.57 9.29 0.45 2.08e-18 Monocyte count; LUSC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg14541582 chr5:601475 NA -0.38 -5.93 -0.31 7.36e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7520050 0.645 rs1768809 chr1:46502836 A/C cg06784218 chr1:46089804 CCDC17 -0.35 -7.14 -0.36 6e-12 Red blood cell count;Reticulocyte count; LUSC trans rs4650994 0.525 rs4650991 chr1:178511165 C/T cg05059571 chr16:84539110 KIAA1609 -0.47 -8.94 -0.44 2.8e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs11792861 0.541 rs838824 chr9:111670707 T/C cg05043794 chr9:111880884 C9orf5 0.3 6.67 0.34 1.04e-10 Menarche (age at onset); LUSC cis rs61774743 0.681 rs10749805 chr1:41850182 C/T cg08462924 chr1:41848221 NA 0.43 7.35 0.37 1.55e-12 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg11366901 chr6:160182831 ACAT2 0.91 12.24 0.56 1.04e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs66887589 0.720 rs11724758 chr4:120239878 G/A cg09307838 chr4:120376055 NA 0.53 8.17 0.41 6.55e-15 Diastolic blood pressure; LUSC cis rs1595825 0.786 rs116046984 chr2:198884413 G/A cg10547527 chr2:198650123 BOLL -0.51 -6.25 -0.32 1.26e-9 Ulcerative colitis; LUSC cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.25 0.59 1.67e-32 Chronic sinus infection; LUSC cis rs9372253 1.000 rs9374170 chr6:110712991 A/G cg00083206 chr6:110721305 DDO -0.43 -7.6 -0.38 2.97e-13 Platelet distribution width; LUSC trans rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.74 -13.45 -0.59 2.91e-33 Brugada syndrome; LUSC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg14664628 chr15:75095509 CSK -0.58 -8.99 -0.44 1.91e-17 Breast cancer; LUSC cis rs9952991 0.941 rs2847280 chr18:12779342 A/G cg23544223 chr18:12777786 NA 0.59 6.27 0.32 1.15e-9 Inflammatory skin disease; LUSC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC trans rs4295623 0.531 rs2898295 chr8:11595969 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.0 -0.31 5.25e-9 Morning vs. evening chronotype; LUSC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg00074818 chr8:8560427 CLDN23 0.48 7.84 0.39 6.16e-14 Obesity-related traits; LUSC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.26 0.37 2.81e-12 Major depressive disorder; LUSC cis rs314370 0.951 rs17884589 chr7:100493711 G/A cg18683606 chr7:100471612 SRRT 0.47 6.16 0.32 2.13e-9 Resting heart rate; LUSC cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg17691542 chr6:26056736 HIST1H1C 0.48 7.16 0.36 5.08e-12 Height; LUSC cis rs4805272 0.512 rs8105613 chr19:29339151 C/T cg03161606 chr19:29218774 NA 0.52 6.11 0.32 2.73e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs7647973 0.588 rs4855848 chr3:49653457 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -7.25 -0.37 2.89e-12 Menarche (age at onset); LUSC cis rs4642101 0.640 rs3901666 chr3:12824363 G/T cg24848339 chr3:12840334 CAND2 -0.38 -8.11 -0.41 9.87e-15 QRS complex (12-leadsum); LUSC cis rs432925 0.600 rs214247 chr16:349221 A/G cg06233593 chr16:337645 AXIN1 0.44 8.41 0.42 1.18e-15 Morning vs. evening chronotype; LUSC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.8 -0.7 2.46e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg16341495 chr8:142228727 SLC45A4 -0.41 -6.97 -0.36 1.72e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7615316 0.934 rs13067795 chr3:142263858 G/T cg16271453 chr3:142027066 XRN1 -0.35 -6.09 -0.32 3.18e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4604732 0.631 rs74154676 chr1:247625894 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs8077889 0.619 rs1230399 chr17:41845403 C/T cg26893861 chr17:41843967 DUSP3 -1.11 -24.54 -0.8 9.94e-77 Triglycerides; LUSC trans rs2055729 0.614 rs17150693 chr8:9741652 C/G cg06636001 chr8:8085503 FLJ10661 0.51 6.34 0.33 7.45e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9341808 0.558 rs3805911 chr6:80933996 A/C cg08355045 chr6:80787529 NA 0.46 7.82 0.39 6.97e-14 Sitting height ratio; LUSC cis rs2718058 0.692 rs2718041 chr7:37783944 A/G cg15028436 chr7:37888078 TXNDC3 0.34 5.75 0.3 2.02e-8 Alzheimer's disease (late onset); LUSC cis rs17270561 0.609 rs1165211 chr6:25800922 T/C cg16482183 chr6:26056742 HIST1H1C 0.53 7.53 0.38 4.66e-13 Iron status biomarkers; LUSC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs4285028 0.747 rs3732407 chr3:121416623 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.89 -12.06 -0.55 4.85e-28 Multiple sclerosis; LUSC cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs7246967 0.673 rs57027767 chr19:22876535 A/G cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs13385 0.769 rs7704262 chr5:139611043 T/A cg26211634 chr5:139558579 C5orf32 0.45 6.99 0.36 1.47e-11 Atrial fibrillation; LUSC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg17264618 chr3:40429014 ENTPD3 0.36 7.38 0.37 1.28e-12 Renal cell carcinoma; LUSC cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.75 10.92 0.51 6.17e-24 Chronic sinus infection; LUSC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC trans rs7647973 0.626 rs1491985 chr3:49739507 G/C cg21659725 chr3:3221576 CRBN -0.65 -7.77 -0.39 9.77e-14 Menarche (age at onset); LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg10729496 chr3:10149963 C3orf24 0.58 7.91 0.4 3.82e-14 Alzheimer's disease; LUSC cis rs1790761 0.658 rs666328 chr11:67335538 G/A cg24690094 chr11:67383802 NA 0.44 8.5 0.42 6.36e-16 Mean corpuscular volume; LUSC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.33e-8 Diabetic kidney disease; LUSC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg08219700 chr8:58056026 NA 0.45 6.04 0.31 4.21e-9 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg23583168 chr7:148888333 NA -0.92 -17.33 -0.69 1.88e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg11235426 chr6:292522 DUSP22 -0.65 -10.65 -0.5 5.53e-23 Menopause (age at onset); LUSC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg07636037 chr3:49044803 WDR6 1.02 17.47 0.69 5.12e-49 Parkinson's disease; LUSC cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg05347473 chr6:146136440 FBXO30 0.52 8.94 0.44 2.63e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg02951883 chr7:2050386 MAD1L1 0.51 9.04 0.44 1.26e-17 Schizophrenia; LUSC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg11812906 chr14:75593930 NEK9 -0.62 -10.08 -0.48 5.03e-21 Height; LUSC cis rs4631830 0.863 rs2843546 chr10:51518688 A/C cg20129853 chr10:51489980 NA -0.34 -6.93 -0.35 2.19e-11 Prostate-specific antigen levels; LUSC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg06238570 chr21:40685208 BRWD1 0.46 7.19 0.37 4.25e-12 Cognitive function; LUSC cis rs7572644 0.766 rs4578808 chr2:28081630 G/T cg27432699 chr2:27873401 GPN1 0.51 6.47 0.33 3.46e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.46 0.5 2.37e-22 Schizophrenia; LUSC cis rs9325144 0.723 rs11169482 chr12:39164327 A/T cg26384229 chr12:38710491 ALG10B 0.6 9.27 0.45 2.36e-18 Morning vs. evening chronotype; LUSC cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg16230307 chr14:35515116 FAM177A1 0.79 10.05 0.48 6.13e-21 Psoriasis; LUSC cis rs7804356 1.000 rs28550029 chr7:26872581 C/T cg03456212 chr7:26904342 SKAP2 -0.55 -6.37 -0.33 6.29e-10 Type 1 diabetes; LUSC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs7904368 0.806 rs12242261 chr10:16872929 T/C cg23933602 chr10:16859644 RSU1 0.55 6.41 0.33 4.99e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs5769707 0.967 rs8141807 chr22:50043738 C/G cg01652190 chr22:50026171 C22orf34 -0.31 -6.37 -0.33 6.44e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg21782813 chr7:2030301 MAD1L1 0.58 10.31 0.49 8.12e-22 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg20243544 chr17:37824526 PNMT -0.44 -5.66 -0.3 3.24e-8 Glomerular filtration rate (creatinine); LUSC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg09021430 chr5:549028 NA -0.55 -7.25 -0.37 2.95e-12 Lung disease severity in cystic fibrosis; LUSC cis rs8060686 0.641 rs73598006 chr16:68074454 C/G cg26727032 chr16:67993705 SLC12A4 -0.42 -5.81 -0.3 1.49e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs10876993 0.728 rs1082503 chr12:58036717 G/A cg15848620 chr12:58087721 OS9 -0.52 -7.49 -0.38 6.36e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg16606324 chr3:10149918 C3orf24 0.65 9.41 0.46 8.08e-19 Alzheimer's disease; LUSC cis rs6087990 0.748 rs4911255 chr20:31357580 A/T cg13636640 chr20:31349939 DNMT3B 1.01 23.33 0.79 4.32e-72 Ulcerative colitis; LUSC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs5770917 1.000 rs2269384 chr22:51011115 C/T cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.62 -5.73 -0.3 2.26e-8 Narcolepsy; LUSC cis rs1775715 0.737 rs2799031 chr10:32173168 C/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.09 0.32 3.14e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg12292205 chr6:26970375 C6orf41 0.56 7.43 0.38 9.01e-13 Intelligence (multi-trait analysis); LUSC cis rs2481665 0.739 rs6674622 chr1:62534938 A/G cg18591186 chr1:62594603 INADL -0.44 -6.96 -0.36 1.86e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7746199 0.736 rs34965299 chr6:27521856 A/G cg01620082 chr3:125678407 NA -0.72 -6.85 -0.35 3.64e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26260540 chr19:589513 HCN2 0.68 6.31 0.33 8.82e-10 Cognitive performance; LUSC cis rs7089973 0.604 rs11196943 chr10:116598865 T/C cg03647239 chr10:116582469 FAM160B1 0.44 7.16 0.36 5.24e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9788682 0.747 rs2938674 chr15:78757913 C/A cg06917634 chr15:78832804 PSMA4 -0.48 -5.87 -0.31 1.05e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.53 0.38 4.76e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 0.967 rs1978061 chr7:91779242 G/A cg17063962 chr7:91808500 NA 0.6 9.65 0.47 1.34e-19 Breast cancer; LUSC cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.54 0.42 4.96e-16 Motion sickness; LUSC trans rs236907 0.859 rs2232824 chr1:171761458 T/C cg13482142 chr2:234261155 NA 0.48 6.05 0.31 3.8e-9 Mean platelet volume; LUSC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg27266027 chr21:40555129 PSMG1 -0.4 -5.84 -0.3 1.24e-8 Cognitive function; LUSC cis rs7089973 0.604 rs17095662 chr10:116596071 A/C cg23260525 chr10:116636907 FAM160B1 0.43 9.1 0.45 8.41e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg17366294 chr4:99064904 C4orf37 0.6 10.68 0.5 4.39e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9790314 1.000 rs336590 chr3:161079583 G/A cg04691961 chr3:161091175 C3orf57 -0.35 -6.07 -0.32 3.43e-9 Morning vs. evening chronotype; LUSC cis rs17270561 0.609 rs1892254 chr6:25750530 T/C cg17691542 chr6:26056736 HIST1H1C 0.58 8.11 0.41 9.78e-15 Iron status biomarkers; LUSC trans rs2228479 0.702 rs17233253 chr16:89828437 A/G cg24644049 chr4:85504048 CDS1 0.88 7.56 0.38 3.94e-13 Skin colour saturation; LUSC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs2439831 0.867 rs2255042 chr15:43834318 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.74 -7.64 -0.39 2.25e-13 Lung cancer in ever smokers; LUSC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg05234568 chr11:5960015 NA -0.6 -8.69 -0.43 1.61e-16 DNA methylation (variation); LUSC cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg18904891 chr8:8559673 CLDN23 0.6 8.08 0.4 1.2e-14 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01883208 chr1:233316809 PCNXL2 0.35 6.08 0.32 3.2e-9 Electrocardiographic conduction measures; LUSC cis rs708547 0.957 rs781667 chr4:57798469 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.57 7.07 0.36 9.29e-12 Response to bleomycin (chromatid breaks); LUSC cis rs7605827 0.930 rs10179765 chr2:15541249 C/T cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.29e-12 Extrinsic epigenetic age acceleration; LUSC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg24250549 chr1:154909240 PMVK 0.65 10.87 0.51 9.05e-24 Prostate cancer; LUSC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg00149659 chr3:10157352 C3orf10 -0.63 -9.23 -0.45 3.26e-18 Alzheimer's disease; LUSC cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.78 -0.54 4.87e-27 Chronic sinus infection; LUSC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg08470875 chr2:26401718 FAM59B -0.65 -8.87 -0.44 4.58e-17 Gut microbiome composition (summer); LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg15534755 chr11:117069859 TAGLN 0.33 5.66 0.3 3.21e-8 Blood protein levels; LUSC cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg12011299 chr4:100065546 ADH4 0.7 10.49 0.5 1.92e-22 Smoking initiation; LUSC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg01657329 chr11:68192670 LRP5 -0.45 -7.2 -0.37 4e-12 Total body bone mineral density; LUSC cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC trans rs62238980 0.614 rs77661466 chr22:32520016 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -5.98 -0.31 5.76e-9 Childhood ear infection; LUSC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg02221750 chr19:17393354 ANKLE1 -0.9 -14.05 -0.61 1.47e-35 Systemic lupus erythematosus; LUSC cis rs7940866 0.801 rs2113928 chr11:130835975 A/G cg12179176 chr11:130786555 SNX19 0.57 8.76 0.43 1.01e-16 Schizophrenia; LUSC cis rs2898681 0.519 rs6848200 chr4:53730181 A/G cg21521518 chr4:53727714 RASL11B 0.44 5.78 0.3 1.73e-8 Optic nerve measurement (cup area); LUSC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2073300 0.609 rs6132606 chr20:23367453 G/A cg12062639 chr20:23401060 NAPB 0.93 8.06 0.4 1.33e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9300255 0.739 rs4759417 chr12:123746510 C/T cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.21 -0.32 1.59e-9 Neutrophil percentage of white cells; LUSC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.95 -0.31 6.88e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6570726 1.000 rs951143 chr6:145932576 C/T cg23711669 chr6:146136114 FBXO30 0.71 11.83 0.54 3.28e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs7746199 0.736 rs34965299 chr6:27521856 A/G cg09904177 chr6:26538194 HMGN4 -0.76 -6.23 -0.32 1.43e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg03452623 chr4:187889614 NA -0.88 -18.29 -0.71 2.99e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs11711311 0.955 rs12630791 chr3:113387717 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.43 5.83 0.3 1.3e-8 IgG glycosylation; LUSC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg10802521 chr3:52805072 NEK4 -0.52 -8.46 -0.42 8.21e-16 Bipolar disorder; LUSC cis rs9527 0.590 rs7897663 chr10:104905604 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg03233332 chr7:66118400 NA -0.43 -6.16 -0.32 2.14e-9 Aortic root size; LUSC cis rs1577917 1.000 rs12213740 chr6:86656733 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.25 -0.41 3.6e-15 Response to antipsychotic treatment; LUSC cis rs2404602 0.692 rs55729975 chr15:76803226 G/A cg23625390 chr15:77176239 SCAPER 0.46 7.13 0.36 6.32e-12 Blood metabolite levels; LUSC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg18196295 chr10:418757 DIP2C 0.51 8.41 0.42 1.17e-15 Psychosis in Alzheimer's disease; LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.28 0.56 7.31e-29 Prudent dietary pattern; LUSC cis rs4243830 1.000 rs12401795 chr1:6594773 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.97 9.44 0.46 6.38e-19 Body mass index; LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg07167872 chr1:205819463 PM20D1 0.84 15.36 0.64 1.16e-40 Menarche (age at onset); LUSC cis rs4478137 0.899 rs10857354 chr4:164239841 A/G cg06758707 chr4:164254230 NPY1R 0.63 9.88 0.48 2.26e-20 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs921968 0.541 rs7604319 chr2:219538799 A/C cg02176678 chr2:219576539 TTLL4 -0.73 -13.88 -0.6 6.54e-35 Mean corpuscular hemoglobin concentration; LUSC trans rs7103411 0.592 rs11030087 chr11:27646246 T/C cg15471856 chr13:19448839 NA -0.44 -6.15 -0.32 2.26e-9 Menarche (age at onset);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs7267979 1.000 rs2257982 chr20:25269630 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.46 0.75 6.72e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs17828380 1.000 rs17829047 chr15:63525952 A/C cg05507819 chr15:63340323 TPM1 -0.7 -5.93 -0.31 7.6e-9 Social communication problems; LUSC cis rs17401966 0.838 rs55676616 chr1:10290126 T/C cg19773385 chr1:10388646 KIF1B -0.51 -8.53 -0.42 5.04e-16 Hepatocellular carcinoma; LUSC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.13 -0.32 2.41e-9 Life satisfaction; LUSC cis rs13082711 0.911 rs2370995 chr3:27428216 C/T cg02860705 chr3:27208620 NA 0.49 8.38 0.42 1.53e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6723226 0.766 rs455737 chr2:32528234 A/G cg02381751 chr2:32503542 YIPF4 0.62 9.32 0.45 1.61e-18 Intelligence (multi-trait analysis); LUSC cis rs7107174 1.000 rs7112234 chr11:78102470 G/A cg02023728 chr11:77925099 USP35 0.45 6.79 0.35 5.09e-11 Testicular germ cell tumor; LUSC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.73 0.35 7.43e-11 Schizophrenia; LUSC cis rs886126 0.684 rs10083213 chr12:111654363 A/G cg10833066 chr12:111807467 FAM109A -0.41 -6.47 -0.33 3.49e-10 Coronary heart disease; LUSC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg15839431 chr19:19639596 YJEFN3 -0.41 -5.68 -0.3 2.93e-8 Tonsillectomy; LUSC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.9 -0.31 9.06e-9 Reticulocyte fraction of red cells; LUSC cis rs1801251 1.000 rs6745879 chr2:233590007 A/G cg25237894 chr2:233734115 C2orf82 0.35 6.51 0.34 2.83e-10 Coronary artery disease; LUSC cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.18 -0.41 6.14e-15 Breast cancer; LUSC cis rs4690686 0.500 rs2168032 chr4:177272957 A/G cg17059388 chr4:177262070 NA 0.45 8.5 0.42 6.35e-16 Essential tremor; LUSC cis rs8031584 0.678 rs35098644 chr15:31145440 A/G cg08704250 chr15:31115839 NA -0.58 -8.86 -0.44 4.74e-17 Huntington's disease progression; LUSC trans rs8060686 0.516 rs7193701 chr16:68185160 A/G cg24192581 chr19:40562106 ZNF780B 0.43 5.99 0.31 5.51e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.92 0.35 2.27e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg18681998 chr4:17616180 MED28 0.88 15.96 0.66 5.35e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1008375 1.000 rs2872958 chr4:17665032 A/G cg16339924 chr4:17578868 LAP3 0.54 7.95 0.4 3e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg21951975 chr1:209979733 IRF6 -0.5 -8.33 -0.41 2.15e-15 Monobrow; LUSC cis rs9462027 0.628 rs9469914 chr6:34827693 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.73 -0.3 2.29e-8 Systemic lupus erythematosus; LUSC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.47e-9 Bipolar disorder; LUSC cis rs977987 0.806 rs4888388 chr16:75394148 G/A cg04384234 chr16:75411784 CFDP1 -0.42 -6.95 -0.36 1.94e-11 Dupuytren's disease; LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg00024416 chr22:24240387 NA 0.47 7.03 0.36 1.19e-11 Urinary 1,3-butadiene metabolite levels in smokers; LUSC trans rs12200782 1.000 rs12213722 chr6:26473083 A/G cg11837749 chr1:55047332 ACOT11 0.59 6.42 0.33 4.55e-10 Small cell lung carcinoma; LUSC cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg13319975 chr6:146136371 FBXO30 0.49 7.36 0.37 1.42e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs12701220 0.894 rs10263252 chr7:1049949 G/A cg20821713 chr7:1055600 C7orf50 -0.57 -7.58 -0.38 3.37e-13 Bronchopulmonary dysplasia; LUSC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg06850241 chr22:41845214 NA 0.34 6.15 0.32 2.25e-9 Vitiligo; LUSC cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg09184832 chr6:79620586 NA -0.43 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); LUSC cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg00071950 chr4:10020882 SLC2A9 -0.57 -9.62 -0.47 1.64e-19 Bone mineral density; LUSC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg23791538 chr6:167370224 RNASET2 0.41 6.54 0.34 2.25e-10 Crohn's disease; LUSC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg07777115 chr5:623756 CEP72 -0.45 -5.7 -0.3 2.62e-8 Obesity-related traits; LUSC cis rs11098499 0.866 rs12501602 chr4:120287935 A/T cg24375607 chr4:120327624 NA 0.7 10.62 0.5 6.76e-23 Corneal astigmatism; LUSC cis rs3820068 0.655 rs11587521 chr1:15839206 T/C cg17385448 chr1:15911702 AGMAT 0.37 5.8 0.3 1.5e-8 Systolic blood pressure; LUSC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg20203395 chr5:56204925 C5orf35 -0.78 -10.62 -0.5 6.82e-23 Initial pursuit acceleration; LUSC cis rs6459788 0.934 rs10237947 chr7:157258109 G/T cg06271696 chr7:157225062 NA 0.4 7.71 0.39 1.45e-13 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs1865721 1.000 rs62089503 chr18:73177766 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -8.19 -0.41 5.65e-15 Intelligence; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg03637614 chr7:129691233 ZC3HC1 0.45 6.11 0.32 2.74e-9 Neuroticism; LUSC cis rs8114671 0.967 rs4911472 chr20:33775377 T/A cg24642439 chr20:33292090 TP53INP2 0.41 5.97 0.31 6.22e-9 Height; LUSC cis rs6782228 0.606 rs2712419 chr3:128340896 T/C cg16766828 chr3:128327626 NA -0.31 -5.66 -0.3 3.3e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.44e-23 Bladder cancer; LUSC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.604 rs12642411 chr4:120580525 T/C cg25214090 chr10:38739885 LOC399744 0.5 7.32 0.37 1.88e-12 Corneal astigmatism; LUSC cis rs9549367 0.789 rs6577035 chr13:113879997 G/A cg18105134 chr13:113819100 PROZ -0.67 -9.55 -0.46 2.88e-19 Platelet distribution width; LUSC cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg12219531 chr12:120966889 COQ5 0.59 7.71 0.39 1.41e-13 High light scatter reticulocyte count; LUSC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg07701084 chr6:150067640 NUP43 0.57 8.78 0.43 8.5e-17 Lung cancer; LUSC cis rs10144321 0.810 rs11624049 chr14:100852820 A/G cg14882082 chr14:100845427 WDR25 -0.38 -7.13 -0.36 6.34e-12 Menarche (age at onset); LUSC cis rs1775715 0.870 rs7095322 chr10:32248491 C/T cg26784012 chr10:32216390 ARHGAP12 -0.36 -5.67 -0.3 3.07e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs61931739 0.500 rs35030191 chr12:34548865 C/T cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Parkinson's disease; LUSC cis rs6500395 1.000 rs1558817 chr16:48730722 G/A cg04672837 chr16:48644449 N4BP1 0.46 6.67 0.34 1.06e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2933343 0.729 rs813732 chr3:128619357 C/T cg11901034 chr3:128598214 ACAD9 -0.4 -6.09 -0.32 3.11e-9 IgG glycosylation; LUSC cis rs6060960 0.502 rs15817 chr20:30193538 A/G cg18721089 chr20:30220636 NA -0.41 -6.57 -0.34 1.93e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs12458462 0.812 rs36073957 chr18:77488441 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.36 -0.33 6.7e-10 Monocyte count; LUSC cis rs7264396 0.790 rs4519606 chr20:34324648 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.72 -0.43 1.33e-16 Total cholesterol levels; LUSC cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.38 0.46 1.04e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9473147 0.516 rs9349416 chr6:47551938 G/A cg02130027 chr6:47444894 CD2AP 0.35 5.7 0.3 2.68e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.41 5.68 0.3 2.94e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs367615 0.506 rs246102 chr5:108699695 C/G cg17395555 chr5:108820864 NA -0.5 -8.83 -0.44 5.9e-17 Colorectal cancer (SNP x SNP interaction); LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.58 10.66 0.5 5e-23 Bipolar disorder; LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 14.02 0.61 1.94e-35 Alzheimer's disease; LUSC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg17507749 chr15:85114479 UBE2QP1 0.69 8.67 0.43 1.92e-16 Schizophrenia; LUSC trans rs747782 0.527 rs12289516 chr11:48234680 G/A cg03929089 chr4:120376271 NA 0.65 6.08 0.32 3.36e-9 Intraocular pressure; LUSC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg12292205 chr6:26970375 C6orf41 -0.62 -9.16 -0.45 5.54e-18 Intelligence (multi-trait analysis); LUSC cis rs9291683 0.588 rs11732054 chr4:9999877 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.6 0.5 8.12e-23 Bone mineral density; LUSC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg07701084 chr6:150067640 NUP43 0.57 8.88 0.44 4.29e-17 Lung cancer; LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg22535103 chr8:58192502 C8orf71 -0.79 -8.22 -0.41 4.44e-15 Developmental language disorder (linguistic errors); LUSC cis rs614226 0.938 rs787824 chr12:120924638 A/G cg21053147 chr12:120880522 NA 0.52 6.45 0.33 3.99e-10 Type 1 diabetes nephropathy; LUSC cis rs72960926 0.744 rs6933439 chr6:75006170 T/C cg03266952 chr6:74778945 NA -0.63 -6.02 -0.31 4.7e-9 Metabolite levels (MHPG); LUSC cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg17063962 chr7:91808500 NA 0.6 9.37 0.46 1.14e-18 Breast cancer; LUSC cis rs9581857 0.615 rs9581848 chr13:28003997 C/T cg22138327 chr13:27999177 GTF3A 0.89 9.45 0.46 6.21e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs10911232 0.507 rs10911196 chr1:182995233 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.05 0.52 2.14e-24 Hypertriglyceridemia; LUSC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg00684032 chr4:1343700 KIAA1530 0.47 8.45 0.42 9.26e-16 Obesity-related traits; LUSC cis rs3540 0.512 rs3862433 chr15:91076028 G/A cg10434728 chr15:90938212 IQGAP1 -0.45 -9.34 -0.46 1.37e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg16145915 chr7:1198662 ZFAND2A -0.44 -6.53 -0.34 2.5e-10 Bronchopulmonary dysplasia; LUSC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg14895029 chr7:2775587 GNA12 -0.41 -6.35 -0.33 6.89e-10 Height; LUSC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg14830002 chr1:247616686 OR2B11 0.49 7.01 0.36 1.33e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg03213289 chr20:61660250 NA 0.68 14.17 0.61 4.91e-36 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.546 rs62320963 chr4:98839297 A/G cg05340658 chr4:99064831 C4orf37 0.62 9.11 0.45 7.88e-18 Colonoscopy-negative controls vs population controls; LUSC trans rs7726839 0.540 rs58599998 chr5:596087 A/G cg25482853 chr8:67687455 SGK3 1.12 16.14 0.66 1.01e-43 Obesity-related traits; LUSC cis rs4664304 1.000 rs55977890 chr2:160776866 C/T cg03641300 chr2:160917029 PLA2R1 -0.4 -6.58 -0.34 1.77e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg23788917 chr6:8435910 SLC35B3 0.49 7.29 0.37 2.2e-12 Motion sickness; LUSC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.33 5.97 0.31 6.08e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -5.92 -0.31 8.21e-9 Developmental language disorder (linguistic errors); LUSC cis rs1943345 0.686 rs10898088 chr11:82874970 G/A cg07047830 chr11:82868014 PCF11 0.65 9.63 0.47 1.61e-19 Obesity-related traits; LUSC cis rs73110464 0.609 rs11170348 chr12:53355588 A/G cg16329197 chr12:53359506 NA -0.66 -9.43 -0.46 7.38e-19 Cancer (pleiotropy); LUSC cis rs7904368 0.754 rs12269366 chr10:16850344 G/A cg14835575 chr10:16859367 RSU1 0.76 9.49 0.46 4.65e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs3942852 0.868 rs11039514 chr11:48109598 A/G cg20307385 chr11:47447363 PSMC3 0.55 6.42 0.33 4.77e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg13047869 chr3:10149882 C3orf24 0.64 9.15 0.45 5.9e-18 Alzheimer's disease; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg07332563 chr6:291687 DUSP22 -0.71 -11.95 -0.55 1.26e-27 Menopause (age at onset); LUSC cis rs765787 0.530 rs3759895 chr15:45543870 G/A cg25801113 chr15:45476975 SHF 0.34 6.97 0.36 1.74e-11 Uric acid levels; LUSC cis rs7739264 0.602 rs6925511 chr6:19773553 C/T cg02404759 chr6:19790362 NA 0.43 6.76 0.35 6.11e-11 Endometriosis; LUSC cis rs9467711 0.591 rs3752417 chr6:26045905 G/C cg21479132 chr6:26055353 NA 0.6 5.67 0.3 3.1e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs8072100 0.934 rs9905583 chr17:45741016 C/T cg08085267 chr17:45401833 C17orf57 -0.6 -10.0 -0.48 8.85e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1448094 0.717 rs7305873 chr12:86290831 G/C cg02569458 chr12:86230093 RASSF9 0.53 8.56 0.42 4.18e-16 Major depressive disorder; LUSC cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC cis rs17685 0.753 rs1637045 chr7:75703895 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.86 -0.39 5.44e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg25428297 chr7:1022841 CYP2W1 0.29 6.13 0.32 2.5e-9 Longevity;Endometriosis; LUSC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 7.89e-25 Mean corpuscular volume; LUSC cis rs72960926 0.590 rs56343698 chr6:74749564 C/T cg03266952 chr6:74778945 NA -0.82 -6.15 -0.32 2.24e-9 Metabolite levels (MHPG); LUSC cis rs983392 0.679 rs600064 chr11:60013451 A/G cg20284999 chr11:59952153 MS4A6A 0.38 6.33 0.33 7.75e-10 Alzheimer's disease (late onset); LUSC cis rs9303401 0.555 rs8071831 chr17:57292950 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.42 6.47 0.33 3.49e-10 Cognitive test performance; LUSC cis rs9814567 0.929 rs1863912 chr3:134205227 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.86 -14.52 -0.62 2.16e-37 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.43 -6.6 -0.34 1.64e-10 Colorectal cancer; LUSC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 10.77 0.51 1.97e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg24881330 chr22:46731750 TRMU 0.85 7.28 0.37 2.36e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs2985684 0.948 rs12886130 chr14:50082753 T/C cg04989706 chr14:50066350 PPIL5 -0.46 -5.88 -0.31 9.79e-9 Carotid intima media thickness; LUSC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.89e-12 Blood metabolite levels; LUSC trans rs2243480 1.000 rs13220979 chr7:65363204 G/A cg10756647 chr7:56101905 PSPH 0.87 8.39 0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs7712401 0.755 rs3756362 chr5:122108890 C/G cg19077854 chr5:122220652 SNX24 0.32 7.08 0.36 8.4e-12 Mean platelet volume; LUSC cis rs6504340 0.739 rs1123630 chr17:46671816 C/T cg09704116 chr17:46666958 LOC404266 -0.39 -6.39 -0.33 5.53e-10 Primary tooth development (number of teeth); LUSC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg25456477 chr12:86230367 RASSF9 0.35 6.16 0.32 2.14e-9 Major depressive disorder; LUSC cis rs208520 0.955 rs17644076 chr6:67004973 A/G cg07460842 chr6:66804631 NA -0.82 -10.48 -0.5 2.13e-22 Exhaled nitric oxide output; LUSC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg01579765 chr21:45077557 HSF2BP -0.52 -10.97 -0.51 4.1e-24 Mean corpuscular volume; LUSC trans rs1376359 0.537 rs510385 chr1:103281607 C/T cg17154563 chr19:40477487 PSMC4 0.48 5.95 0.31 6.87e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs4704187 0.687 rs7709707 chr5:74363575 T/G cg03227963 chr5:74354835 NA 0.33 7.02 0.36 1.28e-11 Response to amphetamines; LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg08027265 chr7:2291960 NA -0.37 -5.94 -0.31 7.24e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.830 rs12673450 chr7:66009220 G/A cg11764359 chr7:65958608 NA 0.7 10.31 0.49 7.92e-22 Aortic root size; LUSC trans rs72674100 1.000 rs3960895 chr4:97963659 A/C cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2721195 1.000 rs1871541 chr8:145681713 G/T cg26752003 chr8:145688521 CYHR1 0.61 10.24 0.49 1.39e-21 Age at first birth; LUSC cis rs7824557 0.564 rs2736294 chr8:11234626 T/C cg27411982 chr8:10470053 RP1L1 -0.37 -5.89 -0.31 9.23e-9 Retinal vascular caliber; LUSC trans rs911555 0.504 rs8006526 chr14:104075015 T/C cg03785828 chr5:81573306 RPS23 -0.37 -6.02 -0.31 4.65e-9 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.545 rs12828001 chr12:39392208 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17976635 chr11:69490191 ORAOV1 -0.46 -7.04 -0.36 1.1e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.45 0.5 2.68e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg09491104 chr22:46646882 C22orf40 -0.71 -7.48 -0.38 6.49e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg03452623 chr4:187889614 NA -0.91 -19.02 -0.72 3.46e-55 Lobe attachment (rater-scored or self-reported); LUSC cis rs1215050 0.782 rs6853916 chr4:98653387 C/T cg05340658 chr4:99064831 C4orf37 -0.46 -7.26 -0.37 2.68e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9640161 0.830 rs1051760 chr7:150070630 A/G cg27494647 chr7:150038898 RARRES2 0.36 5.75 0.3 2.06e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs936229 0.813 rs8033381 chr15:75080685 G/A cg10253484 chr15:75165896 SCAMP2 -0.51 -6.71 -0.34 8.44e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg06008330 chr7:65541103 ASL 0.39 6.09 0.32 3.19e-9 Aortic root size; LUSC cis rs859767 0.501 rs11898465 chr2:135431449 G/T cg12500956 chr2:135428796 TMEM163 -0.29 -6.98 -0.36 1.63e-11 Neuroticism; LUSC trans rs61931739 0.534 rs1844526 chr12:34102780 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs9300255 0.596 rs10732573 chr12:123743883 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.51 -0.34 2.75e-10 Neutrophil percentage of white cells; LUSC cis rs4664308 0.840 rs17218566 chr2:161054748 C/T cg03641300 chr2:160917029 PLA2R1 -0.63 -10.74 -0.51 2.51e-23 Idiopathic membranous nephropathy; LUSC trans rs62238980 0.614 rs117534689 chr22:32392350 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs34172651 0.837 rs12596793 chr16:24823667 C/G cg06028605 chr16:24865363 SLC5A11 0.44 7.97 0.4 2.6e-14 Intelligence (multi-trait analysis); LUSC cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg21770322 chr7:97807741 LMTK2 -0.49 -7.98 -0.4 2.31e-14 Breast cancer; LUSC cis rs6500395 0.775 rs1968903 chr16:48664014 C/T cg04672837 chr16:48644449 N4BP1 0.47 6.96 0.36 1.79e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg23172400 chr8:95962367 TP53INP1 -0.41 -8.19 -0.41 5.46e-15 Type 2 diabetes; LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.82 -0.57 7.44e-31 Platelet count; LUSC cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg23192644 chr19:1315876 NA 0.37 5.96 0.31 6.5e-9 Metabolite levels (Pyroglutamine); LUSC cis rs2404602 0.684 rs28895952 chr15:76856776 A/G cg23625390 chr15:77176239 SCAPER -0.67 -10.37 -0.49 4.84e-22 Blood metabolite levels; LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg13395646 chr4:1353034 KIAA1530 0.65 10.98 0.51 3.89e-24 Obesity-related traits; LUSC cis rs7937682 0.924 rs10891286 chr11:111532691 C/G cg19812747 chr11:111475976 SIK2 -0.49 -6.99 -0.36 1.52e-11 Primary sclerosing cholangitis; LUSC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs6582630 0.638 rs11182428 chr12:38526387 T/C cg13010199 chr12:38710504 ALG10B -0.44 -6.7 -0.34 8.94e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs477692 0.673 rs556253 chr10:131355781 G/A cg05714579 chr10:131428358 MGMT 0.45 6.42 0.33 4.8e-10 Response to temozolomide; LUSC cis rs12368653 0.544 rs11172304 chr12:58097862 T/C cg15848620 chr12:58087721 OS9 -0.45 -6.75 -0.35 6.66e-11 Multiple sclerosis; LUSC trans rs7980799 0.682 rs1384599 chr12:33624579 G/A cg26384229 chr12:38710491 ALG10B -0.59 -8.8 -0.43 7.7e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg18352616 chr4:3374830 RGS12 0.34 6.82 0.35 4.35e-11 Serum sulfate level; LUSC trans rs9693857 1.000 rs9693857 chr8:9267117 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.77 -0.39 1e-13 Systolic blood pressure; LUSC cis rs2835872 0.758 rs1787398 chr21:39037504 A/C cg20424643 chr21:39039972 KCNJ6 -0.44 -7.43 -0.38 8.98e-13 Electroencephalographic traits in alcoholism; LUSC cis rs68170813 0.559 rs78553765 chr7:106930787 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.8 -0.47 4.33e-20 Coronary artery disease; LUSC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg03609598 chr5:56110824 MAP3K1 -0.44 -6.21 -0.32 1.55e-9 Initial pursuit acceleration; LUSC cis rs4474465 0.920 rs12271198 chr11:78158943 G/A cg27205649 chr11:78285834 NARS2 -0.49 -5.85 -0.3 1.18e-8 Alzheimer's disease (survival time); LUSC trans rs61931739 0.534 rs10844729 chr12:34022919 A/G cg26384229 chr12:38710491 ALG10B 0.69 11.03 0.52 2.52e-24 Morning vs. evening chronotype; LUSC trans rs3617 0.573 rs9860296 chr3:52913781 A/G cg01584401 chr7:99063876 ATP5J2 -0.4 -6.01 -0.31 4.78e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs10511400 0.541 rs6438564 chr3:119870476 A/T cg02809009 chr19:50354510 PTOV1 -0.68 -6.19 -0.32 1.81e-9 Economic and political preferences (feminism/equality); LUSC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg14983838 chr19:29218262 NA 0.45 5.7 0.3 2.59e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7246657 0.943 rs6508733 chr19:38000548 A/T cg23950597 chr19:37808831 NA -0.6 -7.22 -0.37 3.49e-12 Coronary artery calcification; LUSC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg21951975 chr1:209979733 IRF6 0.41 6.8 0.35 4.89e-11 Monobrow; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18635645 chr1:85667791 SYDE2 0.4 6.1 0.32 2.91e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs354225 0.584 rs10206143 chr2:54817453 A/T cg01766943 chr2:54829624 SPTBN1 0.51 8.2 0.41 5.15e-15 Schizophrenia; LUSC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg02569458 chr12:86230093 RASSF9 0.59 10.06 0.48 5.54e-21 Major depressive disorder; LUSC cis rs11785400 0.793 rs4403386 chr8:143736770 C/G cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs9902453 0.935 rs4310926 chr17:28433275 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.71 0.47 8.25e-20 Coffee consumption (cups per day); LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg17719053 chr1:75198211 TYW3;CRYZ 0.38 6.21 0.32 1.6e-9 Resistin levels; LUSC cis rs1044826 0.642 rs407958 chr3:139213632 T/C cg00490450 chr3:139108681 COPB2 0.46 7.03 0.36 1.19e-11 Obesity-related traits; LUSC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg20701182 chr2:24300061 SF3B14 0.87 11.27 0.52 3.42e-25 Lymphocyte counts; LUSC cis rs5769765 0.908 rs138864 chr22:50204712 G/A cg26441486 chr22:50317300 CRELD2 0.46 6.96 0.36 1.82e-11 Schizophrenia; LUSC cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg09184832 chr6:79620586 NA -0.44 -7.18 -0.37 4.46e-12 Intelligence (multi-trait analysis); LUSC cis rs6977660 0.652 rs10249291 chr7:19844448 C/G cg07541023 chr7:19748670 TWISTNB 0.7 6.52 0.34 2.55e-10 Thyroid stimulating hormone; LUSC trans rs62103177 0.608 rs551643 chr18:77838970 C/G cg14227996 chr4:17616232 MED28 -0.54 -6.01 -0.31 4.92e-9 Opioid sensitivity; LUSC cis rs7927771 0.524 rs7933896 chr11:47882782 C/T cg20307385 chr11:47447363 PSMC3 0.47 6.86 0.35 3.42e-11 Subjective well-being; LUSC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg17211192 chr8:82754475 SNX16 -0.58 -8.31 -0.41 2.38e-15 Diastolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03634592 chr7:43946398 URGCP -0.53 -6.66 -0.34 1.14e-10 Bipolar disorder and schizophrenia; LUSC trans rs6982636 0.967 rs2954027 chr8:126485294 T/A cg13325919 chr3:181432053 SOX2;SOX2OT -0.32 -6.2 -0.32 1.65e-9 Lipid metabolism phenotypes; LUSC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg06112835 chr11:68658793 MRPL21 -0.5 -7.76 -0.39 1.04e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.34 0.37 1.62e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9660992 0.573 rs12140422 chr1:205187981 G/A cg21643547 chr1:205240462 TMCC2 -0.49 -9.17 -0.45 4.83e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg19318889 chr4:1322082 MAEA 0.51 8.77 0.43 9.29e-17 Obesity-related traits; LUSC cis rs17824933 0.887 rs12790976 chr11:60767420 T/G cg16817237 chr11:60793675 NA 0.4 6.37 0.33 6.35e-10 Multiple sclerosis; LUSC cis rs4595586 0.545 rs4254106 chr12:39389342 G/A cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg00530320 chr1:46809349 NSUN4 0.57 9.0 0.44 1.7e-17 Menopause (age at onset); LUSC cis rs950169 0.610 rs34529571 chr15:84691807 A/G cg12863693 chr15:85201151 NMB 0.37 6.88 0.35 2.97e-11 Schizophrenia; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg07332563 chr6:291687 DUSP22 -0.72 -11.97 -0.55 1.01e-27 Menopause (age at onset); LUSC cis rs12681287 0.547 rs13267858 chr8:87510871 G/A cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07916070 chr3:122283003 PARP9;DTX3L -0.47 -6.39 -0.33 5.44e-10 Hepatitis; LUSC cis rs4588572 0.688 rs11743511 chr5:77692819 C/T cg11547950 chr5:77652471 NA -0.42 -6.53 -0.34 2.44e-10 Triglycerides; LUSC trans rs3960554 0.808 rs9801125 chr7:75792451 C/T cg19862616 chr7:65841803 NCRNA00174 0.9 10.13 0.48 3.31e-21 Eotaxin levels; LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg22963979 chr7:1858916 MAD1L1 -0.46 -6.76 -0.35 6.2e-11 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.765 rs13406288 chr2:99589585 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.77 -0.51 2.03e-23 Chronic sinus infection; LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg14809332 chr8:144654887 C8orf73 -0.37 -5.71 -0.3 2.49e-8 Attention deficit hyperactivity disorder; LUSC cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg06064525 chr11:970664 AP2A2 -0.34 -6.76 -0.35 6.06e-11 Alzheimer's disease (late onset); LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg09033563 chr22:24373618 LOC391322 -0.47 -6.62 -0.34 1.43e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg04414720 chr1:150670196 GOLPH3L 0.5 7.76 0.39 1.07e-13 Melanoma; LUSC cis rs1799949 0.587 rs1824890 chr17:41421904 T/C cg05368731 chr17:41323189 NBR1 0.9 12.66 0.57 2.86e-30 Menopause (age at onset); LUSC cis rs748404 0.697 rs475261 chr15:43546456 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.8 0.39 8.14e-14 Lung cancer; LUSC cis rs6740322 0.895 rs13384080 chr2:43557363 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.53 -0.38 4.87e-13 Coronary artery disease; LUSC cis rs7267979 0.932 rs6132848 chr20:25561645 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.76 0.7 3.77e-50 Liver enzyme levels (alkaline phosphatase); LUSC trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg08313168 chr12:7315531 NA 0.47 6.05 0.31 3.9e-9 Lung disease severity in cystic fibrosis; LUSC cis rs4654899 0.865 rs12410467 chr1:21356055 G/A cg02927042 chr1:21476669 EIF4G3 -0.41 -6.39 -0.33 5.7e-10 Superior frontal gyrus grey matter volume; LUSC cis rs9807841 0.592 rs2742313 chr19:10799750 T/C cg17710535 chr19:10819994 QTRT1 0.42 7.0 0.36 1.38e-11 Inflammatory skin disease; LUSC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg11752832 chr7:134001865 SLC35B4 0.54 8.13 0.41 8.64e-15 Mean platelet volume; LUSC cis rs11190604 1.000 rs35106985 chr10:102307542 T/C cg16342193 chr10:102329863 NA -0.34 -6.18 -0.32 1.82e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6906287 0.647 rs4946350 chr6:118945433 A/C cg21191810 chr6:118973309 C6orf204 0.32 5.9 0.31 9.06e-9 Electrocardiographic conduction measures; LUSC cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.08e-8 Breast cancer; LUSC cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg26384229 chr12:38710491 ALG10B 0.87 14.76 0.63 2.57e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs9287719 0.967 rs12464817 chr2:10707212 A/G cg00105475 chr2:10696890 NA 0.38 6.21 0.32 1.54e-9 Prostate cancer; LUSC cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.96 0.7 5.97e-51 Chronic sinus infection; LUSC cis rs3806843 0.966 rs11741994 chr5:140145949 G/A cg19875535 chr5:140030758 IK 0.46 7.38 0.37 1.31e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs4363385 0.510 rs6677674 chr1:153037601 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -5.97 -0.31 6.05e-9 Inflammatory skin disease; LUSC trans rs10256972 0.706 rs12701970 chr7:1121958 T/C cg13565492 chr6:43139072 SRF -0.42 -6.14 -0.32 2.37e-9 Longevity;Endometriosis; LUSC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03352830 chr11:487213 PTDSS2 0.65 8.22 0.41 4.7e-15 Body mass index; LUSC cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg00409905 chr10:38381863 ZNF37A -0.37 -6.2 -0.32 1.62e-9 Extrinsic epigenetic age acceleration; LUSC cis rs377070 0.816 rs309416 chr4:123621916 T/C cg10495464 chr4:123653540 BBS12;LOC729338 0.41 6.1 0.32 2.87e-9 Mosquito bite size; LUSC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg25427524 chr10:38739819 LOC399744 -0.65 -11.68 -0.54 1.15e-26 Extrinsic epigenetic age acceleration; LUSC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg14558114 chr2:88469736 THNSL2 0.77 6.96 0.36 1.78e-11 Plasma clusterin levels; LUSC cis rs603446 0.840 rs180329 chr11:116622958 G/A cg08985259 chr11:116699649 APOC3 -0.25 -5.65 -0.3 3.39e-8 Triglycerides; LUSC cis rs10754283 1.000 rs10754283 chr1:90112431 G/T cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs11864453 0.679 rs2303285 chr16:72124495 A/C cg16558253 chr16:72132732 DHX38 -0.37 -5.77 -0.3 1.85e-8 Fibrinogen levels; LUSC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg09455208 chr3:40491958 NA 0.53 9.83 0.47 3.34e-20 Renal cell carcinoma; LUSC cis rs974417 0.530 rs11751305 chr6:97296833 G/A cg10979063 chr6:97285822 GPR63 0.44 7.22 0.37 3.55e-12 Body mass index; LUSC cis rs748404 0.650 rs518261 chr15:43573429 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.43 5.96 0.31 6.38e-9 Lung cancer; LUSC cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg16339924 chr4:17578868 LAP3 0.51 7.58 0.38 3.42e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg26597838 chr10:835615 NA 0.79 9.73 0.47 7.58e-20 Eosinophil percentage of granulocytes; LUSC cis rs7539542 0.556 rs10753925 chr1:202854488 C/T cg19681188 chr1:202830198 LOC148709 0.41 6.03 0.31 4.45e-9 Mean platelet volume; LUSC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.34 -6.11 -0.32 2.82e-9 Total body bone mineral density; LUSC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg11344533 chr11:111475393 SIK2 -0.48 -6.78 -0.35 5.35e-11 Primary sclerosing cholangitis; LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg17366294 chr4:99064904 C4orf37 0.6 10.65 0.5 5.59e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs533581 0.873 rs579740 chr16:88973937 A/G cg05579598 chr16:88989069 CBFA2T3 -0.27 -5.95 -0.31 6.75e-9 Social autistic-like traits; LUSC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg25427524 chr10:38739819 LOC399744 -0.74 -14.06 -0.61 1.38e-35 Extrinsic epigenetic age acceleration; LUSC cis rs11690935 0.959 rs973889 chr2:172579954 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.75 -0.63 2.9e-38 Schizophrenia; LUSC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg16797656 chr11:68205561 LRP5 0.37 6.15 0.32 2.23e-9 Total body bone mineral density; LUSC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg04539111 chr16:67997858 SLC12A4 -0.44 -6.08 -0.32 3.27e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg09655341 chr17:79618100 PDE6G -0.27 -6.12 -0.32 2.58e-9 Eye color traits; LUSC cis rs8044995 0.563 rs55968019 chr16:68398111 G/A cg05110241 chr16:68378359 PRMT7 -0.78 -8.91 -0.44 3.36e-17 Schizophrenia; LUSC cis rs12472274 0.646 rs11677736 chr2:239087198 A/T cg17459225 chr2:239074497 NA 0.57 7.94 0.4 3.19e-14 Phospholipid levels (plasma); LUSC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.45 0.42 9.22e-16 Height; LUSC cis rs7267979 1.000 rs7268053 chr20:25328286 A/T cg03522245 chr20:25566470 NINL -0.35 -5.71 -0.3 2.45e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg11244672 chr19:19639970 YJEFN3 -0.58 -7.38 -0.37 1.27e-12 Bipolar disorder; LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg14004847 chr7:1930337 MAD1L1 -0.51 -7.89 -0.4 4.41e-14 Bipolar disorder and schizophrenia; LUSC cis rs2354432 0.546 rs7539416 chr1:146881586 C/T cg25205988 chr1:146714368 CHD1L 0.99 9.79 0.47 4.62e-20 Mitochondrial DNA levels; LUSC cis rs2288073 0.965 rs13387930 chr2:24414400 A/G cg06627628 chr2:24431161 ITSN2 -0.78 -11.24 -0.52 4.46e-25 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs4356932 1.000 rs4359936 chr4:76971976 G/A cg00809888 chr4:76862425 NAAA 0.35 5.85 0.3 1.16e-8 Blood protein levels; LUSC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg26061582 chr7:22766209 IL6 0.5 7.56 0.38 3.9e-13 Lung cancer; LUSC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.18e-11 Developmental language disorder (linguistic errors); LUSC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg03264133 chr6:25882463 NA 0.63 10.68 0.5 4.18e-23 Blood metabolite levels; LUSC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg03233332 chr7:66118400 NA -0.43 -6.21 -0.32 1.6e-9 Aortic root size; LUSC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC trans rs11098499 0.754 rs1814813 chr4:120258207 G/T cg25214090 chr10:38739885 LOC399744 -0.46 -7.28 -0.37 2.43e-12 Corneal astigmatism; LUSC cis rs11756438 0.572 rs1771755 chr6:119018877 A/T cg21191810 chr6:118973309 C6orf204 -0.34 -5.73 -0.3 2.22e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg12257692 chr3:49977190 RBM6 0.24 6.61 0.34 1.49e-10 Intelligence (multi-trait analysis); LUSC cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.93 -0.44 2.91e-17 Axial length; LUSC cis rs6693567 0.565 rs834235 chr1:150362154 C/T cg15654264 chr1:150340011 RPRD2 0.45 7.18 0.37 4.62e-12 Migraine; LUSC cis rs926938 0.520 rs969273 chr1:115256669 G/A cg12756093 chr1:115239321 AMPD1 -0.56 -8.04 -0.4 1.57e-14 Autism; LUSC cis rs2797685 1.000 rs697691 chr1:7885354 A/G cg04725166 chr1:7887271 PER3 -0.47 -6.42 -0.33 4.55e-10 Crohn's disease; LUSC cis rs2882667 0.690 rs825672 chr5:138095643 A/G cg04439458 chr5:138467593 SIL1 0.38 7.11 0.36 6.87e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg26119090 chr2:26468346 HADHA;HADHB 1.11 16.34 0.67 1.63e-44 Mean corpuscular hemoglobin; LUSC cis rs734999 0.505 rs10797437 chr1:2539006 T/C cg18854424 chr1:2615690 NA 0.52 10.81 0.51 1.52e-23 Ulcerative colitis; LUSC cis rs1801251 0.896 rs2305141 chr2:233684402 A/G cg08000102 chr2:233561755 GIGYF2 -0.67 -10.98 -0.51 3.84e-24 Coronary artery disease; LUSC cis rs9473147 0.516 rs6903331 chr6:47562915 A/G cg12968598 chr6:47444699 CD2AP 0.52 8.04 0.4 1.6e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs2688608 0.839 rs2675662 chr10:75599127 A/G cg17411546 chr10:75410026 SYNPO2L 0.43 6.14 0.32 2.32e-9 Inflammatory bowel disease; LUSC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg00343986 chr7:65444356 GUSB -0.48 -7.28 -0.37 2.47e-12 Aortic root size; LUSC cis rs17227506 0.679 rs67768235 chr8:13443286 T/C cg03566418 chr8:13424080 C8orf48 0.42 6.38 0.33 5.99e-10 Nonsyndromic cleft lip with cleft palate; LUSC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg04871131 chr7:94954202 PON1 -0.36 -5.79 -0.3 1.64e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2295359 0.824 rs11209003 chr1:67601132 G/T cg03340356 chr1:67600835 NA 0.43 6.67 0.34 1.08e-10 Psoriasis; LUSC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2073300 1.000 rs6132629 chr20:23451251 G/A cg09953122 chr20:23471693 CST8 -0.72 -6.61 -0.34 1.54e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17492904 chr2:223725746 ACSL3 0.77 6.0 0.31 5.16e-9 Cognitive performance; LUSC cis rs2580764 0.566 rs2920900 chr2:55280083 T/C cg09592903 chr2:55203963 RTN4 0.47 9.33 0.45 1.56e-18 Mean platelet volume; LUSC cis rs2303282 0.682 rs2920706 chr16:56458487 C/T cg00500540 chr16:56394104 NA -0.43 -7.35 -0.37 1.52e-12 Breast cancer; LUSC cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg01579765 chr21:45077557 HSF2BP -0.56 -11.82 -0.54 3.67e-27 Mean corpuscular volume; LUSC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg01206211 chr2:36825736 FEZ2 -0.49 -10.55 -0.5 1.18e-22 Height; LUSC cis rs477692 0.905 rs509041 chr10:131424948 A/G cg11019008 chr10:131425282 MGMT 0.41 6.28 0.32 1.08e-9 Response to temozolomide; LUSC cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg13010199 chr12:38710504 ALG10B 0.48 7.27 0.37 2.56e-12 Morning vs. evening chronotype; LUSC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg18350739 chr11:68623251 NA -0.36 -6.4 -0.33 5.23e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12950390 0.853 rs11655336 chr17:45858836 A/G cg03474202 chr17:45855739 NA 0.29 6.78 0.35 5.55e-11 IgG glycosylation; LUSC cis rs7215564 1.000 rs7215564 chr17:78737287 A/G cg09596252 chr17:78655493 RPTOR 0.53 5.85 0.31 1.15e-8 Myopia (pathological); LUSC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.43 6.32 0.33 8.21e-10 Systemic lupus erythematosus; LUSC cis rs8017423 0.967 rs11621431 chr14:90709221 C/T cg04374321 chr14:90722782 PSMC1 0.75 12.09 0.55 3.85e-28 Mortality in heart failure; LUSC cis rs1790761 0.803 rs2302264 chr11:67207426 G/A cg24690094 chr11:67383802 NA -0.31 -5.67 -0.3 3.13e-8 Mean corpuscular volume; LUSC cis rs2898681 0.581 rs28618986 chr4:53677902 G/C cg00338735 chr4:53728038 RASL11B 0.42 5.75 0.3 2.01e-8 Optic nerve measurement (cup area); LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg19747945 chr6:42946146 PEX6 -0.34 -5.67 -0.3 3.11e-8 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs2204008 0.580 rs11520047 chr12:38051778 T/A cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.25e-9 Bladder cancer; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg19717773 chr7:2847554 GNA12 -0.42 -6.69 -0.34 9.16e-11 Height; LUSC cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg24558204 chr6:135376177 HBS1L -0.59 -8.72 -0.43 1.37e-16 High light scatter reticulocyte percentage of red cells; LUSC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.51 0.59 1.69e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs16854884 0.586 rs7611326 chr3:143736374 C/T cg06585982 chr3:143692056 C3orf58 0.52 8.26 0.41 3.46e-15 Economic and political preferences (feminism/equality); LUSC cis rs12286929 0.839 rs12421648 chr11:115013447 G/A cg04055981 chr11:115044050 NA 0.35 6.09 0.32 3.18e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17685 0.753 rs869804 chr7:75688954 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.48 -0.38 6.84e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.53 0.38 4.66e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6845621 0.727 rs1377147 chr4:18917424 T/G cg12196642 chr4:18937545 NA -0.34 -6.34 -0.33 7.56e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC cis rs7267979 0.966 rs3827014 chr20:25371559 C/T cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2172802 0.629 rs62304005 chr4:62494219 C/T cg04118610 chr4:62707027 LPHN3 0.45 6.03 0.31 4.3e-9 Partial epilepsies; LUSC cis rs59698941 0.943 rs66746130 chr5:132245615 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg15557168 chr22:42548783 NA -0.44 -6.68 -0.34 1.01e-10 Schizophrenia; LUSC cis rs67478160 0.609 rs1547604 chr14:104270659 A/T cg01849466 chr14:104193079 ZFYVE21 -0.56 -9.13 -0.45 6.91e-18 Schizophrenia; LUSC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg18230493 chr5:56204884 C5orf35 -0.87 -12.94 -0.58 2.55e-31 Initial pursuit acceleration; LUSC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.51 6.65 0.34 1.17e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg26597838 chr10:835615 NA 0.99 13.98 0.61 2.67e-35 Eosinophil percentage of granulocytes; LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg26314531 chr2:26401878 FAM59B -0.7 -9.8 -0.47 4.11e-20 Gut microbiome composition (summer); LUSC cis rs738322 0.836 rs4821741 chr22:38514745 A/G cg17652424 chr22:38574118 PLA2G6 -0.29 -5.85 -0.3 1.16e-8 Cutaneous nevi; LUSC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.78 -0.35 5.37e-11 Alzheimer's disease (late onset); LUSC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg00990874 chr7:1149470 C7orf50 0.51 6.32 0.33 8.3e-10 Bronchopulmonary dysplasia; LUSC cis rs4845459 0.933 rs6662654 chr1:152593081 G/T cg08895932 chr1:152778580 LCE1C -0.38 -6.53 -0.34 2.46e-10 Psoriasis; LUSC cis rs1009647 1.000 rs35502084 chr14:55876263 C/T cg04306507 chr14:55594613 LGALS3 0.45 7.41 0.38 1.02e-12 Testicular germ cell tumor; LUSC cis rs4363385 0.747 rs2075739 chr1:152975495 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC trans rs208520 0.802 rs1342959 chr6:66883329 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -15.15 -0.64 7.76e-40 Exhaled nitric oxide output; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13819586 chr14:24685205 MDP1 0.46 7.13 0.36 6.36e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg04414720 chr1:150670196 GOLPH3L 0.51 7.92 0.4 3.58e-14 Melanoma; LUSC cis rs6700896 0.500 rs4655575 chr1:66135668 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.51 5.8 0.3 1.51e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7481584 0.926 rs10833024 chr11:3010390 C/T cg08508325 chr11:3079039 CARS 0.32 6.09 0.32 3.02e-9 Calcium levels; LUSC cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs34779708 0.833 rs12777517 chr10:35473927 T/G cg03585969 chr10:35415529 CREM 0.63 9.28 0.45 2.21e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg20406979 chr6:167373233 NA -0.26 -6.16 -0.32 2.1e-9 Crohn's disease; LUSC cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg04586622 chr2:25135609 ADCY3 -0.4 -8.51 -0.42 5.85e-16 Body mass index; LUSC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg22823121 chr1:150693482 HORMAD1 0.59 9.09 0.45 8.83e-18 Tonsillectomy; LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03576123 chr11:487126 PTDSS2 -1.01 -10.64 -0.5 5.93e-23 Body mass index; LUSC cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg18681998 chr4:17616180 MED28 0.81 14.71 0.63 4.13e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11711311 1.000 rs11711311 chr3:113430599 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.13 0.36 6.16e-12 IgG glycosylation; LUSC cis rs4555082 1.000 rs7146012 chr14:105757566 G/A cg27165867 chr14:105738592 BRF1 -0.52 -7.74 -0.39 1.16e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg15448220 chr1:150897856 SETDB1 0.42 6.14 0.32 2.29e-9 Melanoma; LUSC cis rs9549367 0.789 rs35569628 chr13:113872712 T/C cg00898013 chr13:113819073 PROZ -0.57 -8.64 -0.43 2.44e-16 Platelet distribution width; LUSC cis rs11190604 1.000 rs28522614 chr10:102323141 T/A cg16342193 chr10:102329863 NA -0.35 -5.87 -0.31 1.04e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs13418410 0.715 rs10198451 chr2:33801017 G/A cg04131969 chr2:33951647 MYADML -0.46 -6.08 -0.32 3.21e-9 Non-response to antidepressants and depression; LUSC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.31 -0.45 1.79e-18 Prostate cancer; LUSC cis rs9910055 0.659 rs227580 chr17:42223068 C/T cg08499158 chr17:42289980 UBTF 0.5 8.58 0.43 3.5e-16 Total body bone mineral density; LUSC cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg04990556 chr1:26633338 UBXN11 -0.45 -5.9 -0.31 9.17e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg04871131 chr7:94954202 PON1 -0.39 -6.13 -0.32 2.41e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs240110 0.539 rs6934256 chr6:101338728 G/A cg09795085 chr6:101329169 ASCC3 0.48 7.11 0.36 6.89e-12 Neuroticism; LUSC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg12365402 chr11:9010492 NRIP3 0.43 8.03 0.4 1.73e-14 Hemoglobin concentration; LUSC cis rs859767 0.704 rs6750788 chr2:135362981 A/G cg12500956 chr2:135428796 TMEM163 -0.28 -6.24 -0.32 1.33e-9 Neuroticism; LUSC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg19230755 chr7:65878503 NA -0.42 -6.0 -0.31 5.22e-9 Aortic root size; LUSC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg21361702 chr7:150065534 REPIN1 0.57 9.02 0.44 1.48e-17 Blood protein levels;Circulating chemerin levels; LUSC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg16423285 chr20:60520624 NA -0.9 -12.28 -0.56 7.08e-29 Obesity-related traits; LUSC cis rs6554196 0.508 rs6554199 chr4:55522488 G/T cg18836493 chr4:55524333 KIT -0.42 -7.23 -0.37 3.41e-12 Monocyte count; LUSC cis rs12493885 0.818 rs61791545 chr3:153768888 G/A cg17054900 chr3:154042577 DHX36 -0.75 -7.66 -0.39 2.06e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7107174 1.000 rs11601196 chr11:78043431 A/C cg02023728 chr11:77925099 USP35 0.47 6.77 0.35 5.87e-11 Testicular germ cell tumor; LUSC cis rs600231 0.708 rs661403 chr11:65242478 A/G cg17120908 chr11:65337727 SSSCA1 -0.53 -9.23 -0.45 3.22e-18 Bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24409649 chr12:31479318 FAM60A 0.48 6.38 0.33 5.88e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.967 rs373527 chr6:145801861 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.33 0.33 8.08e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg19812747 chr11:111475976 SIK2 0.54 7.74 0.39 1.16e-13 Primary sclerosing cholangitis; LUSC cis rs737008 0.922 rs1559394 chr16:11369205 A/G cg00044050 chr16:11439710 C16orf75 -0.55 -8.62 -0.43 2.65e-16 Obesity-related traits; LUSC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.23 0.32 1.43e-9 Menarche (age at onset); LUSC cis rs7582180 0.652 rs11123830 chr2:100974747 A/G cg12002119 chr2:101014098 CHST10 0.35 5.67 0.3 3.17e-8 Intelligence (multi-trait analysis); LUSC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg21963583 chr11:68658836 MRPL21 0.56 8.37 0.42 1.58e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7584330 0.518 rs78856668 chr2:238438055 A/C cg16989719 chr2:238392110 NA -0.49 -6.22 -0.32 1.53e-9 Prostate cancer; LUSC cis rs4851254 0.660 rs1821830 chr2:100680279 C/T cg22139774 chr2:100720529 AFF3 -0.44 -5.82 -0.3 1.37e-8 Intelligence (multi-trait analysis); LUSC cis rs10193935 0.901 rs2118889 chr2:42451683 G/T cg27598129 chr2:42591480 NA -0.63 -8.51 -0.42 5.94e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg27535305 chr1:53392650 SCP2 0.36 6.71 0.34 8.29e-11 Monocyte count; LUSC cis rs1160297 0.576 rs67939368 chr2:53093152 G/C cg07782112 chr2:53107842 NA 0.44 7.18 0.37 4.58e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs4792901 0.802 rs9898286 chr17:41562542 T/G cg22562494 chr17:41607896 ETV4 -0.33 -6.19 -0.32 1.8e-9 Dupuytren's disease; LUSC cis rs3862030 0.720 rs12569526 chr10:104237007 A/G cg22532475 chr10:104410764 TRIM8 0.24 5.76 0.3 1.93e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs4930103 1.000 rs4930103 chr11:2024544 G/A cg06197492 chr11:2016605 H19 0.37 6.04 0.31 4.22e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs11785400 1.000 rs4484678 chr8:143730796 A/G cg10596483 chr8:143751796 JRK 0.61 9.39 0.46 9.97e-19 Schizophrenia; LUSC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg20476274 chr7:133979776 SLC35B4 -0.76 -13.6 -0.6 7.86e-34 Mean platelet volume; LUSC cis rs4499344 0.730 rs259285 chr19:33164697 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.73 0.54 7.5e-27 Mean platelet volume; LUSC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11644478 chr21:40555479 PSMG1 0.95 18.98 0.72 5.3e-55 Cognitive function; LUSC cis rs847577 0.572 rs847573 chr7:97681761 C/T cg21770322 chr7:97807741 LMTK2 -0.41 -6.33 -0.33 8.11e-10 Breast cancer; LUSC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg11764359 chr7:65958608 NA -0.69 -10.54 -0.5 1.28e-22 Aortic root size; LUSC cis rs7107174 1.000 rs4245459 chr11:78065959 T/G cg02023728 chr11:77925099 USP35 0.45 6.62 0.34 1.42e-10 Testicular germ cell tumor; LUSC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg22532475 chr10:104410764 TRIM8 0.3 5.97 0.31 6.17e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg14541582 chr5:601475 NA -0.38 -5.93 -0.31 7.36e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7819412 0.505 rs17782554 chr8:11022106 C/G cg21775007 chr8:11205619 TDH -0.52 -7.38 -0.37 1.26e-12 Triglycerides; LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.56 0.65 1.98e-41 Platelet count; LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg18404041 chr3:52824283 ITIH1 -0.56 -10.64 -0.5 5.73e-23 Bipolar disorder; LUSC cis rs7909074 1.000 rs10900128 chr10:45393201 G/T cg04218760 chr10:45406644 TMEM72 -0.3 -7.45 -0.38 8.22e-13 Mean corpuscular volume; LUSC cis rs17014483 0.749 rs2924350 chr4:89626391 A/G cg01026744 chr4:89619053 NAP1L5;HERC3 0.71 6.47 0.33 3.5e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1577917 1.000 rs955227 chr6:86651032 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.86 -0.44 4.97e-17 Response to antipsychotic treatment; LUSC cis rs534126 1.000 rs557797 chr7:142921509 T/C cg04039957 chr7:143013207 CLCN1 0.3 5.82 0.3 1.39e-8 Cancer; LUSC cis rs208520 0.690 rs1563929 chr6:66702108 G/A cg07460842 chr6:66804631 NA 1.09 16.98 0.68 4.51e-47 Exhaled nitric oxide output; LUSC cis rs1448094 0.802 rs56391398 chr12:86424114 C/T cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.49e-9 Major depressive disorder; LUSC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg10664184 chr19:17420304 DDA1 0.47 6.13 0.32 2.46e-9 Systemic lupus erythematosus; LUSC cis rs193541 0.621 rs898391 chr5:122082166 T/C cg19077854 chr5:122220652 SNX24 0.36 7.17 0.37 4.75e-12 Glucose homeostasis traits; LUSC cis rs9325144 0.647 rs17518186 chr12:38883665 T/C cg13010199 chr12:38710504 ALG10B -0.49 -7.38 -0.37 1.28e-12 Morning vs. evening chronotype; LUSC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg08280861 chr8:58055591 NA 0.53 6.41 0.33 5.04e-10 Developmental language disorder (linguistic errors); LUSC cis rs6445797 0.662 rs1491166 chr3:56570097 A/G cg13792233 chr3:56591045 CCDC66 -0.41 -5.81 -0.3 1.44e-8 Gastritis; LUSC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg10360139 chr7:1886902 MAD1L1 -0.39 -5.81 -0.3 1.44e-8 Bipolar disorder and schizophrenia; LUSC cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg03517284 chr6:25882590 NA 0.65 11.31 0.53 2.54e-25 Blood metabolite levels; LUSC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg25036284 chr2:26402008 FAM59B 0.66 8.51 0.42 5.91e-16 Gut microbiome composition (summer); LUSC cis rs7264396 0.832 rs224349 chr20:34045392 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.72 -0.35 7.88e-11 Total cholesterol levels; LUSC cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg18252515 chr7:66147081 NA -1.21 -13.88 -0.6 6.79e-35 Diabetic kidney disease; LUSC cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg16850897 chr7:100343110 ZAN -0.61 -8.5 -0.42 6.61e-16 Other erythrocyte phenotypes; LUSC cis rs12155623 0.619 rs870397 chr8:49861225 C/T cg22283653 chr8:49824208 NA 0.34 6.78 0.35 5.43e-11 Sudden cardiac arrest; LUSC cis rs11711311 0.911 rs9817327 chr3:113478500 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 7.13 0.36 6.3e-12 IgG glycosylation; LUSC cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs4141404 0.818 rs5997897 chr22:31570436 G/A cg22777020 chr22:31556080 RNF185 -0.48 -6.91 -0.35 2.51e-11 Paclitaxel-induced neuropathy; LUSC cis rs3796619 1.000 rs1466215 chr4:1072220 C/T cg27284194 chr4:1044797 NA 0.51 8.48 0.42 7.14e-16 Recombination rate (males); LUSC cis rs7523050 0.643 rs35050241 chr1:109404876 T/C cg08274380 chr1:109419600 GPSM2 1.07 10.65 0.5 5.34e-23 Fat distribution (HIV); LUSC cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg15485101 chr11:133734466 NA 0.4 7.2 0.37 4.13e-12 Childhood ear infection; LUSC cis rs8141529 0.843 rs1065497 chr22:29279991 C/T cg02153584 chr22:29168773 CCDC117 0.6 8.4 0.42 1.32e-15 Lymphocyte counts; LUSC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg19592336 chr6:28129416 ZNF389 0.46 5.93 0.31 7.48e-9 Depression; LUSC cis rs6121246 0.529 rs6060359 chr20:30209740 A/G cg13852791 chr20:30311386 BCL2L1 0.78 8.84 0.44 5.79e-17 Mean corpuscular hemoglobin; LUSC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg03354898 chr7:1950403 MAD1L1 -0.37 -7.14 -0.36 5.91e-12 Schizophrenia; LUSC cis rs2730245 0.959 rs2527201 chr7:158738611 G/T cg11984989 chr7:158649758 WDR60 -1.0 -17.47 -0.69 5.16e-49 Height; LUSC cis rs10744422 1.000 rs936083 chr12:123338964 A/G cg25930673 chr12:123319894 HIP1R -0.72 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.73 0.39 1.28e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs72781680 0.678 rs56145919 chr2:24088489 A/G cg08917208 chr2:24149416 ATAD2B 0.59 6.81 0.35 4.57e-11 Lymphocyte counts; LUSC cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg02753203 chr1:228287806 NA -0.65 -11.02 -0.52 2.68e-24 Diastolic blood pressure; LUSC cis rs2486288 0.656 rs11629807 chr15:45547037 T/C cg09092052 chr15:45571596 NA 0.46 6.41 0.33 5.09e-10 Glomerular filtration rate; LUSC trans rs1864729 0.688 rs2567768 chr8:98303151 G/A cg08679828 chr8:102218111 ZNF706 -0.73 -6.43 -0.33 4.38e-10 Estradiol plasma levels (breast cancer); LUSC trans rs8073060 0.821 rs11080355 chr17:33872694 T/A cg19694781 chr19:47549865 TMEM160 0.7 10.77 0.51 2.0500000000000001e-23 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2404602 0.669 rs9788684 chr15:77194838 A/T cg23625390 chr15:77176239 SCAPER 0.47 7.09 0.36 8.13e-12 Blood metabolite levels; LUSC cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg21770322 chr7:97807741 LMTK2 0.5 8.48 0.42 7.3e-16 Breast cancer; LUSC cis rs2637266 0.756 rs2583063 chr10:78558048 T/C cg18941641 chr10:78392320 NA 0.37 6.7 0.34 8.79e-11 Pulmonary function; LUSC cis rs9322817 0.691 rs4142531 chr6:105324811 G/A cg02098413 chr6:105308735 HACE1 0.27 5.8 0.3 1.52e-8 Thyroid stimulating hormone; LUSC cis rs765787 0.530 rs11636404 chr15:45535861 C/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.72 -0.43 1.29e-16 Uric acid levels; LUSC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg06046430 chr4:77819534 ANKRD56 0.5 7.3 0.37 2.1e-12 Emphysema distribution in smoking; LUSC cis rs1580019 0.844 rs1901202 chr7:32503724 A/T cg06627557 chr7:32535165 LSM5;AVL9 0.84 12.52 0.57 9.44e-30 Cognitive ability; LUSC cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -10.01 -0.48 8.56e-21 Personality dimensions; LUSC cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg22529645 chr1:3704559 LRRC47 0.35 6.12 0.32 2.56e-9 Red cell distribution width; LUSC cis rs524023 0.957 rs561193 chr11:64353029 A/G cg07220939 chr11:64358617 SLC22A12 0.22 5.81 0.3 1.45e-8 Urate levels in obese individuals; LUSC cis rs1577917 0.570 rs114854865 chr6:86554236 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC trans rs208520 0.609 rs208436 chr6:66897470 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.81 -11.69 -0.54 1.06e-26 Exhaled nitric oxide output; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.33 0.45 1.52e-18 Prudent dietary pattern; LUSC cis rs3784262 0.900 rs12911071 chr15:58314848 G/A cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.67 -0.3 3.02e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg08742575 chr21:47604166 C21orf56 0.46 7.04 0.36 1.1e-11 Testicular germ cell tumor; LUSC cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg15147215 chr3:52552868 STAB1 -0.31 -6.11 -0.32 2.79e-9 Bipolar disorder; LUSC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg11663144 chr21:46675770 NA -0.39 -6.68 -0.34 1e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg06618935 chr21:46677482 NA -0.4 -8.06 -0.4 1.41e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs965513 1.000 rs7864322 chr9:100548934 C/T cg13688889 chr9:100608707 NA -0.55 -8.17 -0.41 6.32e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs11030122 0.702 rs66503725 chr11:3980998 G/A cg18678763 chr11:4115507 RRM1 -0.46 -6.02 -0.31 4.53e-9 Mean platelet volume;Platelet distribution width; LUSC trans rs7824557 0.564 rs2736294 chr8:11234626 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.61 -0.38 2.74e-13 Retinal vascular caliber; LUSC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs734999 0.550 rs2985855 chr1:2531372 A/C cg18932078 chr1:2524107 MMEL1 -0.33 -7.21 -0.37 3.83e-12 Ulcerative colitis; LUSC cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg03146154 chr1:46216737 IPP 0.55 8.21 0.41 5.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC cis rs3849570 0.643 rs1969433 chr3:81968869 T/C cg07356753 chr3:81810745 GBE1 -0.48 -7.13 -0.36 6.17e-12 Waist circumference;Body mass index; LUSC cis rs7607369 0.617 rs12987009 chr2:219658170 A/T cg02176678 chr2:219576539 TTLL4 -0.66 -12.62 -0.57 4.06e-30 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg05585544 chr11:47624801 NA -0.42 -7.24 -0.37 3.06e-12 Subjective well-being; LUSC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.74 -0.35 6.97e-11 Tonsillectomy; LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs6754459 1.000 rs6754459 chr2:3707423 C/T cg19052272 chr2:3704530 ALLC -0.45 -8.3 -0.41 2.54e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs3740713 1.000 rs73440636 chr11:18473556 C/T cg23797887 chr11:18477753 LDHAL6A -0.54 -6.53 -0.34 2.45e-10 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg23172400 chr8:95962367 TP53INP1 -0.39 -8.09 -0.4 1.13e-14 Type 2 diabetes; LUSC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.967 rs3102341 chr16:89450744 G/A cg00750074 chr16:89608354 SPG7 -0.47 -8.2 -0.41 5.19e-15 Multiple myeloma (IgH translocation); LUSC cis rs1609391 0.543 rs7651085 chr3:136625339 C/G cg15507776 chr3:136538369 TMEM22 0.5 8.25 0.41 3.79e-15 Neuroticism; LUSC cis rs10463316 0.817 rs10476770 chr5:150777720 G/C cg03212797 chr5:150827313 SLC36A1 -0.47 -7.2 -0.37 3.95e-12 Metabolite levels (Pyroglutamine); LUSC cis rs11645898 0.748 rs11647889 chr16:72052034 C/G cg14768367 chr16:72042858 DHODH -0.77 -8.3 -0.41 2.53e-15 Blood protein levels; LUSC cis rs763014 0.966 rs15564 chr16:677854 G/T cg07256732 chr16:621771 PIGQ -0.35 -6.4 -0.33 5.41e-10 Height; LUSC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC trans rs1927790 0.727 rs1925122 chr13:96938173 T/C cg03198741 chr6:1003969 LOC285768 -0.39 -5.98 -0.31 5.82e-9 Body mass index; LUSC cis rs7523050 0.908 rs67425757 chr1:109398656 T/G cg08274380 chr1:109419600 GPSM2 0.92 9.73 0.47 7.24e-20 Fat distribution (HIV); LUSC cis rs6967385 0.560 rs10279958 chr7:12350593 T/C cg20607287 chr7:12443886 VWDE 0.4 6.03 0.31 4.25e-9 Response to taxane treatment (placlitaxel); LUSC cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg04850211 chr1:228464232 OBSCN 0.32 5.75 0.3 1.97e-8 Diastolic blood pressure; LUSC cis rs1448094 0.842 rs12318815 chr12:86452281 T/C cg02569458 chr12:86230093 RASSF9 -0.36 -5.72 -0.3 2.4e-8 Major depressive disorder; LUSC cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.54 -8.14 -0.41 7.78e-15 Axial length; LUSC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg19717773 chr7:2847554 GNA12 -0.36 -6.28 -0.32 1.07e-9 Height; LUSC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg24829409 chr8:58192753 C8orf71 -0.64 -7.75 -0.39 1.15e-13 Developmental language disorder (linguistic errors); LUSC trans rs9871760 1.000 rs9860652 chr3:126996775 C/T cg17872838 chr13:52607339 UTP14C 0.35 6.23 0.32 1.44e-9 Whole-brain volume; LUSC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg25039879 chr17:56429692 SUPT4H1 0.7 9.44 0.46 6.73e-19 Cognitive test performance; LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg11494091 chr17:61959527 GH2 -0.71 -15.45 -0.65 5.07e-41 Prudent dietary pattern; LUSC cis rs67366981 0.925 rs56245630 chr14:77714185 T/C cg22824376 chr14:77648248 TMEM63C 0.58 5.67 0.3 3.05e-8 Obsessive-compulsive symptoms; LUSC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg21770322 chr7:97807741 LMTK2 0.42 7.23 0.37 3.26e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7267979 0.966 rs2387882 chr20:25378802 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2228479 0.541 rs62052173 chr16:89950739 T/C cg26513180 chr16:89883248 FANCA 0.61 5.84 0.3 1.22e-8 Skin colour saturation; LUSC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg09359103 chr1:154839909 KCNN3 -0.69 -16.09 -0.66 1.6e-43 Prostate cancer; LUSC cis rs877282 1.000 rs11253366 chr10:773386 C/T cg17470449 chr10:769945 NA 0.5 7.0 0.36 1.41e-11 Uric acid levels; LUSC cis rs6692729 0.814 rs2246221 chr1:227075402 C/T cg10327440 chr1:227177885 CDC42BPA -0.51 -7.38 -0.37 1.23e-12 Electrodermal activity; LUSC cis rs11098499 0.754 rs11724409 chr4:120252361 A/G cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs7824557 0.564 rs2437152 chr8:11235497 G/A cg27411982 chr8:10470053 RP1L1 -0.38 -6.01 -0.31 4.97e-9 Retinal vascular caliber; LUSC cis rs11696845 0.761 rs11698203 chr20:43357899 C/T cg25301532 chr20:43378953 KCNK15 -0.35 -6.27 -0.32 1.1e-9 Obesity-related traits; LUSC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -8.96 -0.44 2.28e-17 Monocyte percentage of white cells; LUSC cis rs9814567 0.806 rs4535271 chr3:134321669 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.36 -0.56 3.72e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6980507 0.524 rs62510967 chr8:42441374 C/G cg09913449 chr8:42400586 C8orf40 0.44 7.26 0.37 2.76e-12 Glycated hemoglobin levels; LUSC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg18196295 chr10:418757 DIP2C 0.45 7.41 0.38 1.05e-12 Psychosis in Alzheimer's disease; LUSC cis rs7520050 0.771 rs4660882 chr1:46116292 C/T cg06784218 chr1:46089804 CCDC17 0.29 5.83 0.3 1.31e-8 Red blood cell count;Reticulocyte count; LUSC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -5.7 -0.3 2.68e-8 Neuroticism; LUSC cis rs9467773 1.000 rs9393728 chr6:26509330 C/G cg09904177 chr6:26538194 HMGN4 0.73 13.28 0.59 1.37e-32 Intelligence (multi-trait analysis); LUSC trans rs6952808 0.792 rs12536261 chr7:1953571 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.07 0.32 3.43e-9 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs4964805 1.000 rs73192053 chr12:104190855 A/G cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg05341575 chr12:125625032 AACS -0.37 -5.96 -0.31 6.33e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7215564 0.818 rs4075782 chr17:78556325 A/G cg23238734 chr17:78661607 RPTOR -0.54 -7.08 -0.36 8.36e-12 Myopia (pathological); LUSC cis rs72781680 0.699 rs72794291 chr2:23897935 C/T cg08917208 chr2:24149416 ATAD2B 0.97 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC trans rs9929218 0.954 rs7186333 chr16:68815838 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.54 -0.53 3.86e-26 Colorectal cancer; LUSC cis rs7589728 0.858 rs1914734 chr2:88529509 T/C cg04511125 chr2:88470314 THNSL2 0.6 6.25 0.32 1.25e-9 Plasma clusterin levels; LUSC cis rs4654899 1.000 rs6663452 chr1:21423154 T/C cg01072550 chr1:21505969 NA -0.53 -8.09 -0.4 1.15e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6464929 1.000 rs6464929 chr7:148717467 G/A cg23583168 chr7:148888333 NA 0.48 6.15 0.32 2.2e-9 Pediatric bone mineral content (hip); LUSC cis rs9814567 1.000 rs2370642 chr3:134222136 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.81 -0.6 1.26e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7582180 0.652 rs4851311 chr2:100980398 C/T cg12002119 chr2:101014098 CHST10 0.35 5.75 0.3 2.02e-8 Intelligence (multi-trait analysis); LUSC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg16325326 chr1:53192061 ZYG11B 0.82 14.59 0.62 1.21e-37 Monocyte count; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.4 -6.53 -0.34 2.41e-10 Prudent dietary pattern; LUSC cis rs4343996 0.967 rs10276933 chr7:3349262 C/A cg21248987 chr7:3385318 SDK1 0.39 6.63 0.34 1.37e-10 Motion sickness; LUSC cis rs7584330 0.704 rs72620820 chr2:238358844 G/A cg14458575 chr2:238380390 NA 0.86 15.27 0.64 2.68e-40 Prostate cancer; LUSC cis rs936229 0.768 rs936226 chr15:75069282 C/T cg14664628 chr15:75095509 CSK -0.99 -16.36 -0.67 1.35e-44 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs2137920 0.945 rs2254409 chr10:50238453 A/G cg27141751 chr10:50231850 C10orf72 0.39 5.86 0.31 1.14e-8 Migraine with aura; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18337363 chr3:52569053 NT5DC2 0.24 5.74 0.3 2.16e-8 Electroencephalogram traits; LUSC cis rs12824058 0.798 rs7968728 chr12:130804696 T/A cg23887609 chr12:130822674 PIWIL1 0.47 7.1 0.36 7.61e-12 Menopause (age at onset); LUSC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg23283495 chr1:209979779 IRF6 0.63 7.87 0.4 4.97e-14 Cleft lip with or without cleft palate; LUSC cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg26061582 chr7:22766209 IL6 0.46 6.9 0.35 2.57e-11 Lung cancer; LUSC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg24675056 chr1:15929824 NA 0.43 7.46 0.38 7.66e-13 Systolic blood pressure; LUSC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg26659404 chr1:25747437 RHCE -0.28 -5.73 -0.3 2.25e-8 Plateletcrit;Mean corpuscular volume; LUSC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg00701064 chr4:6280414 WFS1 0.59 14.34 0.62 1.17e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg17747265 chr1:1875780 NA -0.75 -17.66 -0.69 9.63e-50 Body mass index; LUSC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg15320075 chr8:145703422 NA -0.65 -10.62 -0.5 7.07e-23 Age at first birth; LUSC cis rs11155671 0.530 rs7758020 chr6:150208111 T/C cg04369109 chr6:150039330 LATS1 -0.4 -5.78 -0.3 1.67e-8 Testicular germ cell tumor; LUSC cis rs6722750 0.870 rs35899183 chr2:64408776 C/G cg22352474 chr2:64371530 PELI1 0.52 7.76 0.39 1.07e-13 Neuroticism; LUSC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg07414643 chr4:187882934 NA 0.54 9.99 0.48 9.75e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg24642439 chr20:33292090 TP53INP2 0.49 7.37 0.37 1.36e-12 Height; LUSC cis rs10979 0.965 rs9376759 chr6:143886959 G/A cg25407410 chr6:143891975 LOC285740 -0.7 -10.98 -0.52 3.66e-24 Hypospadias; LUSC cis rs1215050 0.744 rs966380 chr4:98435389 C/T cg05340658 chr4:99064831 C4orf37 0.42 6.6 0.34 1.62e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7937890 1.000 rs2970334 chr11:14329355 C/T cg22961513 chr11:14280813 SPON1 0.34 5.7 0.3 2.65e-8 Mitochondrial DNA levels; LUSC cis rs12760731 0.720 rs1397185 chr1:178381698 G/A cg00404053 chr1:178313656 RASAL2 0.6 6.25 0.32 1.26e-9 Obesity-related traits; LUSC cis rs9840812 0.683 rs8045 chr3:136055459 T/C cg15507776 chr3:136538369 TMEM22 -0.48 -6.18 -0.32 1.89e-9 Fibrinogen levels; LUSC cis rs7582720 1.000 rs114520702 chr2:203697092 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10876993 0.928 rs2640636 chr12:58077544 A/G cg15848620 chr12:58087721 OS9 -0.57 -8.04 -0.4 1.56e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg11494091 chr17:61959527 GH2 0.65 13.58 0.6 9.43e-34 Prudent dietary pattern; LUSC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg09323728 chr8:95962352 TP53INP1 -0.39 -7.79 -0.39 8.44e-14 Type 2 diabetes; LUSC cis rs1712517 0.740 rs4293062 chr10:105052624 G/A cg05636881 chr10:105038444 INA 0.39 6.32 0.33 8.31e-10 Migraine; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg20683799 chr1:63989117 ITGB3BP;EFCAB7 0.53 6.49 0.33 3.08e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs68170813 0.559 rs6946036 chr7:106853659 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.89 -0.48 2.21e-20 Coronary artery disease; LUSC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg00933542 chr6:150070202 PCMT1 0.32 6.68 0.34 1.01e-10 Lung cancer; LUSC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg24642439 chr20:33292090 TP53INP2 -0.56 -8.52 -0.42 5.67e-16 Height; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg21724239 chr8:58056113 NA 0.83 9.79 0.47 4.72e-20 Developmental language disorder (linguistic errors); LUSC cis rs860295 0.812 rs7556519 chr1:155827546 T/C cg08949192 chr1:155289623 RUSC1;FDPS -0.34 -5.65 -0.3 3.52e-8 Body mass index; LUSC cis rs4642101 0.534 rs13316229 chr3:12807371 C/T cg05775895 chr3:12838266 CAND2 0.48 7.41 0.38 1.04e-12 QRS complex (12-leadsum); LUSC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -5.85 -0.3 1.2e-8 Personality dimensions; LUSC cis rs8099014 0.954 rs9961522 chr18:56107279 T/C cg12907477 chr18:56117327 MIR122 0.41 6.56 0.34 2.05e-10 Platelet count; LUSC cis rs3849570 1.000 rs3849570 chr3:81792112 C/A cg07356753 chr3:81810745 GBE1 -0.69 -11.18 -0.52 7.16e-25 Waist circumference;Body mass index; LUSC cis rs11098499 0.954 rs35063680 chr4:120387102 T/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.59e-25 Corneal astigmatism; LUSC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg00579200 chr11:133705235 NA 0.41 6.01 0.31 4.82e-9 Childhood ear infection; LUSC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7589728 0.925 rs80065975 chr2:88502758 G/A cg04511125 chr2:88470314 THNSL2 0.71 6.64 0.34 1.25e-10 Plasma clusterin levels; LUSC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg11965913 chr1:205819406 PM20D1 0.42 6.13 0.32 2.54e-9 Parkinson's disease; LUSC cis rs9300255 0.566 rs1716169 chr12:123716930 A/T cg13010344 chr12:123464640 ARL6IP4 -0.47 -5.78 -0.3 1.76e-8 Neutrophil percentage of white cells; LUSC cis rs7568458 0.811 rs3755015 chr2:85764041 G/A cg17127132 chr2:85788382 GGCX 0.46 7.18 0.37 4.44e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2075671 0.903 rs4729602 chr7:100260591 T/C cg16850897 chr7:100343110 ZAN -0.52 -7.15 -0.36 5.63e-12 Other erythrocyte phenotypes; LUSC cis rs6582630 0.555 rs12828034 chr12:38274249 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.34 -0.42 2.03e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg10556349 chr10:835070 NA 0.56 6.34 0.33 7.39e-10 Eosinophil percentage of granulocytes; LUSC trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.36 -5.85 -0.3 1.2e-8 Longevity;Endometriosis; LUSC cis rs909341 0.868 rs2738758 chr20:62349625 C/G cg09650180 chr20:62225654 GMEB2 0.46 6.15 0.32 2.26e-9 Atopic dermatitis; LUSC cis rs10875746 0.903 rs3782911 chr12:48483492 T/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 1.97e-8 Longevity (90 years and older); LUSC cis rs12286929 0.606 rs11823428 chr11:115071222 C/A cg04055981 chr11:115044050 NA 0.44 7.83 0.39 6.42e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6121246 0.909 rs6089058 chr20:30326338 T/G cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs61332075 0.501 rs55706928 chr2:239445806 T/C cg18131467 chr2:239335373 ASB1 -0.66 -6.18 -0.32 1.82e-9 Lung function (FEV1/FVC); LUSC cis rs2274273 0.840 rs11547116 chr14:55738165 T/C cg04306507 chr14:55594613 LGALS3 0.56 13.13 0.58 4.79e-32 Protein biomarker; LUSC cis rs11190604 1.000 rs1106565 chr10:102211613 T/C cg07080220 chr10:102295463 HIF1AN 0.64 8.34 0.42 2.01e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg06108461 chr20:60628389 TAF4 -1.01 -17.41 -0.69 9.34e-49 Body mass index; LUSC cis rs12155623 0.668 rs6472114 chr8:49789561 T/C cg22283653 chr8:49824208 NA -0.49 -10.91 -0.51 6.59e-24 Sudden cardiac arrest; LUSC cis rs4499344 0.633 rs166310 chr19:33155187 G/A cg22980127 chr19:33182716 NUDT19 -0.44 -6.45 -0.33 3.88e-10 Mean platelet volume; LUSC cis rs791888 0.760 rs10788561 chr10:89423245 A/G cg13926569 chr10:89418898 PAPSS2 0.33 6.54 0.34 2.3e-10 Magnesium levels; LUSC cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg21573476 chr21:45109991 RRP1B -0.39 -6.38 -0.33 5.94e-10 Mean corpuscular volume; LUSC cis rs11630290 0.806 rs11631544 chr15:64098557 A/G cg12036633 chr15:63758958 NA -0.59 -7.03 -0.36 1.2e-11 Iris characteristics; LUSC cis rs9653442 0.510 rs12712068 chr2:100764439 A/G cg22139774 chr2:100720529 AFF3 -0.42 -7.3 -0.37 2.16e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs7944735 0.507 rs7396592 chr11:48100837 T/C cg03929089 chr4:120376271 NA -0.57 -7.05 -0.36 1.04e-11 Intraocular pressure; LUSC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg06494592 chr3:125709126 NA -0.51 -6.25 -0.32 1.23e-9 Blood pressure (smoking interaction); LUSC cis rs500891 0.953 rs580595 chr6:84195751 A/G cg08257003 chr6:84140564 ME1 -0.33 -6.85 -0.35 3.47e-11 Platelet-derived growth factor BB levels; LUSC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 12.04 0.55 5.77e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg13647721 chr17:30228624 UTP6 0.59 5.78 0.3 1.76e-8 Hip circumference adjusted for BMI; LUSC cis rs7937682 0.924 rs875258 chr11:111530607 C/A cg22437258 chr11:111473054 SIK2 0.5 6.89 0.35 2.78e-11 Primary sclerosing cholangitis; LUSC cis rs6500395 1.000 rs11649236 chr16:48632478 C/T cg04672837 chr16:48644449 N4BP1 0.49 7.34 0.37 1.65e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg13385521 chr17:29058706 SUZ12P 0.56 6.1 0.32 2.9e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs72848980 0.512 rs56033495 chr10:105383611 G/A cg00126946 chr10:105363258 SH3PXD2A 0.39 5.7 0.3 2.63e-8 White matter hyperintensity burden; LUSC cis rs1728785 0.901 rs933713 chr16:68581378 C/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg22105103 chr4:187893119 NA 0.71 13.88 0.6 6.72e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs17021463 0.902 rs10516950 chr4:95254730 C/T cg11021082 chr4:95130006 SMARCAD1 0.39 7.22 0.37 3.62e-12 Testicular germ cell tumor; LUSC cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.76 -0.51 2.19e-23 Monocyte percentage of white cells; LUSC cis rs4776059 0.798 rs28368342 chr15:52921573 A/G cg22715398 chr15:52968154 KIAA1370 0.57 7.39 0.37 1.19e-12 Schizophrenia; LUSC cis rs10744422 1.000 rs1587856 chr12:123342229 A/G cg25930673 chr12:123319894 HIP1R -0.67 -6.83 -0.35 4.15e-11 Schizophrenia; LUSC cis rs143111788 1 rs143111788 chr6:41919175 CCAGCTACT/C cg17623882 chr6:41773611 USP49 -0.58 -9.45 -0.46 5.97e-19 Red cell distribution width; LUSC cis rs4555082 0.834 rs11622165 chr14:105759761 C/A cg27165867 chr14:105738592 BRF1 -0.54 -7.62 -0.39 2.57e-13 Mean platelet volume;Platelet distribution width; LUSC trans rs208520 1.000 rs9453663 chr6:66976077 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 12.16 0.55 2e-28 Exhaled nitric oxide output; LUSC cis rs8072100 0.713 rs4968228 chr17:45497548 T/C cg08085267 chr17:45401833 C17orf57 -0.51 -7.3 -0.37 2.07e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg07636037 chr3:49044803 WDR6 1.0 16.07 0.66 1.81e-43 Parkinson's disease; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg07362569 chr17:61921086 SMARCD2 0.39 7.95 0.4 2.85e-14 Prudent dietary pattern; LUSC cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg04455712 chr21:45112962 RRP1B 0.45 8.64 0.43 2.4e-16 Mean corpuscular volume; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg07362569 chr17:61921086 SMARCD2 0.35 7.24 0.37 3.11e-12 Prudent dietary pattern; LUSC cis rs11124063 1 rs11124063 chr2:106458806 T/C cg14210321 chr2:106509881 NCK2 -0.39 -5.71 -0.3 2.43e-8 Platelet distribution width; LUSC cis rs7241530 0.610 rs12455089 chr18:75899708 T/G cg14642773 chr18:75888474 NA 0.38 5.69 0.3 2.75e-8 Educational attainment (years of education); LUSC cis rs2692947 0.770 rs72492163 chr2:96417816 G/A cg22654517 chr2:96458247 NA 0.35 6.65 0.34 1.21e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg18850127 chr7:39170497 POU6F2 0.6 9.4 0.46 8.61e-19 IgG glycosylation; LUSC cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.55 0.34 2.22e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2354432 0.607 rs7537483 chr1:146709877 C/G cg25205988 chr1:146714368 CHD1L 0.95 8.5 0.42 6.49e-16 Mitochondrial DNA levels; LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1461503 0.966 rs11218910 chr11:122842861 G/A cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs61931739 0.500 rs9795938 chr12:34587739 C/T cg06521331 chr12:34319734 NA 0.41 6.75 0.35 6.66e-11 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg08888203 chr3:10149979 C3orf24 0.63 9.09 0.45 8.92e-18 Alzheimer's disease; LUSC cis rs7267979 1.000 rs404394 chr20:25447896 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg22546130 chr22:19950026 COMT 0.39 8.68 0.43 1.81e-16 Blood metabolite levels; LUSC cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.51 -0.42 6.11e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6714710 0.603 rs2044458 chr2:98377512 A/T cg26665480 chr2:98280029 ACTR1B 0.58 8.37 0.42 1.65e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6977660 0.619 rs2158379 chr7:19783977 A/G cg07541023 chr7:19748670 TWISTNB 0.61 6.46 0.33 3.63e-10 Thyroid stimulating hormone; LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg07677032 chr17:61819896 STRADA 0.54 8.94 0.44 2.69e-17 Prudent dietary pattern; LUSC cis rs1371867 0.846 rs1692006 chr8:101252462 C/T cg06002616 chr8:101225028 SPAG1 0.42 7.05 0.36 1e-11 Atrioventricular conduction; LUSC cis rs6901250 0.807 rs339303 chr6:117176691 C/T cg12892004 chr6:117198278 RFX6 -0.45 -8.59 -0.43 3.3e-16 C-reactive protein levels; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg11766577 chr21:47581405 C21orf56 0.47 7.09 0.36 8.02e-12 Testicular germ cell tumor; LUSC cis rs1395 0.778 rs11126918 chr2:27438710 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.36 0.37 1.47e-12 Blood metabolite levels; LUSC trans rs4596713 0.508 rs13289984 chr9:71775047 A/C cg25283916 chr1:242222868 NA -0.29 -6.0 -0.31 5.05e-9 Headache; LUSC cis rs1570884 0.516 rs7334387 chr13:50172133 T/A cg08779649 chr13:50194554 NA 0.4 6.92 0.35 2.36e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs1577917 0.958 rs66807489 chr6:86440702 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.91 -0.44 3.33e-17 Response to antipsychotic treatment; LUSC cis rs2898290 0.622 rs7822109 chr8:11349147 T/C cg21775007 chr8:11205619 TDH -0.47 -6.96 -0.36 1.81e-11 Systolic blood pressure; LUSC trans rs6445525 1.000 rs4417899 chr3:65996110 T/C cg12639933 chr12:57626296 SHMT2 0.34 6.24 0.32 1.3e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs7647973 0.710 rs7629322 chr3:49621994 C/T cg21659725 chr3:3221576 CRBN -0.71 -8.17 -0.41 6.45e-15 Menarche (age at onset); LUSC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg12463550 chr7:65579703 CRCP -0.57 -8.62 -0.43 2.65e-16 Aortic root size; LUSC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg02569458 chr12:86230093 RASSF9 0.57 9.62 0.47 1.64e-19 Major depressive disorder; LUSC cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg20701182 chr2:24300061 SF3B14 0.88 11.42 0.53 1.05e-25 Lymphocyte counts; LUSC cis rs240764 0.531 rs1070990 chr6:101264412 T/A cg09795085 chr6:101329169 ASCC3 0.45 6.58 0.34 1.87e-10 Neuroticism; LUSC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs9430161 0.611 rs2095920 chr1:11033457 T/A cg27631724 chr1:11040367 C1orf127 0.55 9.55 0.46 2.88e-19 Ewing sarcoma; LUSC cis rs11785400 0.612 rs10110864 chr8:143750072 A/G cg10596483 chr8:143751796 JRK 0.52 7.62 0.38 2.67e-13 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16007711 chr8:22857750 RHOBTB2 0.51 7.78 0.39 9.39e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg16339924 chr4:17578868 LAP3 -0.69 -10.91 -0.51 6.43e-24 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4782309 0.544 rs8060579 chr16:88751667 G/C cg27087555 chr16:88793112 FAM38A -0.88 -6.56 -0.34 2.03e-10 Hair color; LUSC cis rs1882538 0.512 rs13241734 chr7:133122742 C/G cg10665199 chr7:133106180 EXOC4 0.56 7.61 0.38 2.76e-13 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.956 rs10896341 chr11:68313180 G/A cg01657329 chr11:68192670 LRP5 -0.39 -5.67 -0.3 3.17e-8 Total body bone mineral density; LUSC cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.86 -0.35 3.41e-11 Menopause (age at onset); LUSC cis rs11051970 0.918 rs7309115 chr12:32541241 A/G cg24626660 chr12:32551988 NA 0.38 6.07 0.32 3.43e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1801251 0.752 rs709938 chr2:233746457 C/T cg25237894 chr2:233734115 C2orf82 -0.35 -6.63 -0.34 1.38e-10 Coronary artery disease; LUSC cis rs72781680 0.716 rs6718631 chr2:24036086 A/G cg08917208 chr2:24149416 ATAD2B -0.6 -6.89 -0.35 2.84e-11 Lymphocyte counts; LUSC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg05043794 chr9:111880884 C9orf5 -0.39 -8.23 -0.41 4.14e-15 Menarche (age at onset); LUSC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg08045932 chr20:61659980 NA 0.59 10.47 0.5 2.2e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs4911253 0.527 rs853859 chr20:31402269 A/G cg13636640 chr20:31349939 DNMT3B 0.82 15.01 0.63 2.89e-39 Lymphocyte counts; LUSC cis rs72634258 0.945 rs34466510 chr1:8147412 T/C cg00042356 chr1:8021962 PARK7 0.79 9.53 0.46 3.29e-19 Inflammatory bowel disease; LUSC cis rs25645 0.792 rs8077456 chr17:38128765 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.66 11.42 0.53 9.71e-26 Myeloid white cell count; LUSC cis rs870825 0.616 rs28673855 chr4:185627416 T/G cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs4604732 0.631 rs10802509 chr1:247627158 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs41271473 1.000 rs4391638 chr1:228878481 A/C cg16512390 chr1:228756714 NA 0.5 6.04 0.31 4.05e-9 Chronic lymphocytic leukemia; LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg20887711 chr4:1340912 KIAA1530 -0.7 -11.0 -0.52 3.11e-24 Longevity; LUSC cis rs7560272 0.723 rs4346412 chr2:73843571 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -7.44 -0.38 8.53e-13 Schizophrenia; LUSC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg17971929 chr21:40555470 PSMG1 0.78 12.61 0.57 4.21e-30 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02392688 chr17:27916351 GIT1 -0.4 -6.07 -0.32 3.43e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs941408 1.000 rs2260416 chr19:2796355 G/A cg19676328 chr12:49525230 TUBA1B -0.51 -8.01 -0.4 1.97e-14 Total cholesterol levels; LUSC cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg11244672 chr19:19639970 YJEFN3 -0.6 -7.18 -0.37 4.52e-12 Bipolar disorder; LUSC cis rs16867321 0.694 rs11889207 chr2:181424527 A/C cg23363182 chr2:181467187 NA -0.54 -8.46 -0.42 8.35e-16 Obesity; LUSC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg15691649 chr6:25882328 NA 0.51 7.58 0.38 3.4e-13 Blood metabolite levels; LUSC cis rs7524258 0.868 rs7544314 chr1:7266744 G/C cg07173049 chr1:7289937 CAMTA1 0.35 7.16 0.36 5.11e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7107174 1.000 rs10899456 chr11:78000155 C/G cg02023728 chr11:77925099 USP35 0.45 6.68 0.34 9.87e-11 Testicular germ cell tumor; LUSC cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.69 0.3 2.8e-8 Crohn's disease; LUSC cis rs2414856 0.510 rs72758930 chr15:64660853 G/A cg08069370 chr15:64387884 SNX1 -0.78 -6.58 -0.34 1.84e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg06191203 chr2:152266755 RIF1 -0.55 -7.27 -0.37 2.51e-12 Lung cancer; LUSC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg22029157 chr1:209979665 IRF6 0.72 8.77 0.43 9.3e-17 Cleft lip with or without cleft palate; LUSC cis rs2245008 0.950 rs824400 chr16:83989936 C/G cg07978099 chr16:83986941 OSGIN1 -0.55 -7.51 -0.38 5.58e-13 Pursuit maintenance gain; LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg16606324 chr3:10149918 C3orf24 0.6 8.69 0.43 1.63e-16 Alzheimer's disease; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01370129 chr11:61735138 FTH1 0.43 6.6 0.34 1.66e-10 Asthma; LUSC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs2806561 0.704 rs2868573 chr1:23508253 C/G cg12483005 chr1:23474871 LUZP1 0.42 6.45 0.33 3.98e-10 Height; LUSC cis rs765787 0.530 rs12913123 chr15:45516425 C/T cg24006582 chr15:45444508 DUOX1 0.65 9.45 0.46 6.25e-19 Uric acid levels; LUSC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg25251562 chr2:3704773 ALLC -0.38 -6.92 -0.35 2.34e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs8141797 0.818 rs762271 chr22:24448082 T/C cg00411358 chr22:24577142 SUSD2 0.62 6.08 0.32 3.31e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg02569458 chr12:86230093 RASSF9 0.58 9.82 0.47 3.59e-20 Major depressive disorder; LUSC cis rs10489202 0.686 rs6427113 chr1:167845787 C/T cg24449463 chr1:168025552 DCAF6 0.49 5.78 0.3 1.7e-8 Schizophrenia; LUSC cis rs4423214 0.840 rs1790341 chr11:71177578 T/C cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg17971929 chr21:40555470 PSMG1 0.78 13.72 0.6 2.7e-34 Cognitive function; LUSC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg26335602 chr6:28129616 ZNF389 -0.4 -5.79 -0.3 1.66e-8 Depression; LUSC cis rs950169 0.960 rs12905475 chr15:84800495 G/A cg11189052 chr15:85197271 WDR73 0.49 5.92 0.31 7.95e-9 Schizophrenia; LUSC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg20135002 chr11:47629003 NA -0.45 -7.08 -0.36 8.3e-12 Subjective well-being; LUSC trans rs3749237 1.000 rs2307021 chr3:49765483 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.9 0.35 2.63e-11 Resting heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02149880 chr2:216878419 MREG 0.44 7.07 0.36 9.06e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.57 0.5 9.83e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs877282 0.583 rs11595057 chr10:819203 A/C cg13042288 chr15:90349979 ANPEP -0.43 -6.86 -0.35 3.27e-11 Uric acid levels; LUSC cis rs17407555 0.606 rs59871456 chr4:10014441 G/A cg00071950 chr4:10020882 SLC2A9 -0.51 -6.15 -0.32 2.2e-9 Schizophrenia (age at onset); LUSC cis rs300703 0.542 rs67993758 chr2:179594 C/T cg21211680 chr2:198530 NA -0.54 -6.68 -0.34 9.72e-11 Blood protein levels; LUSC cis rs6500395 1.000 rs11076573 chr16:48632758 A/G cg04672837 chr16:48644449 N4BP1 0.49 7.28 0.37 2.36e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9905704 0.846 rs28363318 chr17:56798207 T/C cg12560992 chr17:57184187 TRIM37 0.58 8.4 0.42 1.34e-15 Testicular germ cell tumor; LUSC cis rs2836633 0.929 rs4514962 chr21:40041753 C/T cg12884169 chr21:40033163 ERG 0.61 12.34 0.56 4.41e-29 Coronary artery disease; LUSC cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg27129171 chr3:47204927 SETD2 -0.58 -8.55 -0.42 4.42e-16 Birth weight; LUSC cis rs55665837 1.000 rs11023215 chr11:14436970 C/T cg19336497 chr11:14380999 RRAS2 -0.35 -7.1 -0.36 7.52e-12 Vitamin D levels; LUSC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.17 0.45 4.85e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs7197653 0.748 rs61460037 chr16:68336125 A/C cg05110241 chr16:68378359 PRMT7 -0.74 -7.94 -0.4 3.13e-14 Magnesium levels; LUSC cis rs9467711 0.606 rs12174623 chr6:26373086 C/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7633770 0.805 rs11130098 chr3:46661926 A/G cg11219411 chr3:46661640 NA -0.48 -10.24 -0.49 1.42e-21 Coronary artery disease; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg17541715 chr7:1216824 NA -0.4 -6.3 -0.33 9.63e-10 Longevity;Endometriosis; LUSC trans rs11088226 0.846 rs2154500 chr21:33926391 T/C cg09050820 chr6:167586206 TCP10L2 0.67 10.13 0.48 3.3e-21 Gastritis; LUSC cis rs12620999 0.887 rs10929214 chr2:238037436 C/G cg23555395 chr2:238036564 NA -0.52 -8.79 -0.43 8.3e-17 Systemic lupus erythematosus; LUSC cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg01689657 chr7:91764605 CYP51A1 0.32 5.84 0.3 1.25e-8 Breast cancer; LUSC cis rs4494114 1.000 rs9438984 chr1:39361615 G/A cg25970120 chr1:39325951 RRAGC -0.4 -6.23 -0.32 1.4e-9 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15556085 chr6:118972834 C6orf204 -0.4 -6.12 -0.32 2.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7954584 0.551 rs1169072 chr12:122401501 C/T cg01765077 chr12:122356316 WDR66 -0.44 -6.2 -0.32 1.66e-9 Mean corpuscular volume; LUSC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.9 0.4 4.01e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg03354898 chr7:1950403 MAD1L1 -0.35 -6.62 -0.34 1.42e-10 Bipolar disorder and schizophrenia; LUSC cis rs9788721 0.836 rs55983731 chr15:78735269 C/T cg18825076 chr15:78729989 IREB2 -0.59 -9.76 -0.47 5.72e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs3862435 0.572 rs2601164 chr15:90908402 A/G cg22089800 chr15:90895588 ZNF774 -0.56 -6.01 -0.31 4.85e-9 Response to exercise (triglyceride level interaction); LUSC cis rs9283706 0.641 rs6414805 chr5:66322600 T/C cg11590213 chr5:66331682 MAST4 0.46 6.66 0.34 1.13e-10 Coronary artery disease; LUSC trans rs10435719 0.580 rs13260712 chr8:11782570 A/C cg06636001 chr8:8085503 FLJ10661 -0.44 -6.37 -0.33 6.25e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2463822 1.000 rs2463820 chr11:62112290 A/T cg06239285 chr11:62104954 ASRGL1 0.96 10.41 0.49 3.72e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1448094 0.935 rs4919775 chr12:86339985 T/C cg00310523 chr12:86230176 RASSF9 0.4 7.31 0.37 1.94e-12 Major depressive disorder; LUSC cis rs10078 0.559 rs2671891 chr5:456386 A/G cg08916839 chr5:415575 AHRR 0.75 7.09 0.36 7.88e-12 Fat distribution (HIV); LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg08859206 chr1:53392774 SCP2 -0.68 -13.04 -0.58 1.06e-31 Monocyte count; LUSC cis rs2486288 0.656 rs8039540 chr15:45551842 C/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.89 -0.4 4.34e-14 Glomerular filtration rate; LUSC cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.72 0.47 8.11e-20 Personality dimensions; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg16203607 chr17:62500946 DDX5 0.32 6.33 0.33 8.07e-10 Tuberculosis; LUSC cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg05985134 chr18:33552581 C18orf21 0.51 7.1 0.36 7.51e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7172677 0.732 rs55922358 chr15:75313967 G/C cg14664628 chr15:75095509 CSK 0.6 7.85 0.39 5.88e-14 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg09184832 chr6:79620586 NA -0.44 -7.18 -0.37 4.63e-12 Intelligence (multi-trait analysis); LUSC trans rs4843747 0.671 rs28679286 chr16:88106307 C/T cg26811252 chr16:29126840 RRN3P2 0.56 8.92 0.44 3.14e-17 Menopause (age at onset); LUSC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg13390004 chr1:15929781 NA -0.42 -7.1 -0.36 7.39e-12 Systolic blood pressure; LUSC cis rs8072100 0.727 rs4794052 chr17:45769236 T/C cg08085267 chr17:45401833 C17orf57 -0.46 -6.71 -0.34 8.46e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1215050 0.755 rs7696354 chr4:98820330 T/C cg05340658 chr4:99064831 C4orf37 0.41 6.3 0.33 9.42e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8013055 0.796 rs11628497 chr14:105970789 C/T cg19700328 chr14:106028568 NA -0.41 -6.88 -0.35 2.95e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs62244186 0.535 rs59726036 chr3:44850074 G/T cg16615211 chr3:44902933 MIR564;TMEM42 0.37 6.52 0.34 2.67e-10 Depressive symptoms; LUSC cis rs908922 0.676 rs10888492 chr1:152499908 G/C cg20991723 chr1:152506922 NA 0.52 9.83 0.47 3.41e-20 Hair morphology; LUSC cis rs7809950 0.822 rs2712228 chr7:107300340 A/C cg23024343 chr7:107201750 COG5 0.47 7.13 0.36 6.23e-12 Coronary artery disease; LUSC cis rs11105298 1.000 rs11105298 chr12:89876143 C/T cg00757033 chr12:89920650 WDR51B -0.56 -10.09 -0.48 4.67e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg11812906 chr14:75593930 NEK9 0.67 11.56 0.53 3.23e-26 Height; LUSC cis rs34638657 0.732 rs2967359 chr16:82202968 G/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.53 -0.34 2.4e-10 Lung adenocarcinoma; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg06914050 chr7:56119237 PSPH;CCT6A 0.72 6.44 0.33 4.18e-10 Myocardial infarction; LUSC cis rs7246967 0.551 rs34897132 chr19:22826891 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.09 0.64 1.4e-39 Intelligence (multi-trait analysis); LUSC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg00339695 chr16:24857497 SLC5A11 0.58 8.84 0.44 5.78e-17 Intelligence (multi-trait analysis); LUSC cis rs877282 0.891 rs11253406 chr10:796297 G/A cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC trans rs4718428 0.705 rs13231140 chr7:66361618 C/G cg18876405 chr7:65276391 NA 0.49 6.71 0.34 8.46e-11 Corneal structure; LUSC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg24110177 chr3:50126178 RBM5 -0.54 -9.1 -0.45 8.58e-18 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg03806693 chr22:41940476 POLR3H -1.05 -14.76 -0.63 2.55e-38 Vitiligo; LUSC trans rs11992162 0.569 rs11786149 chr8:11800818 G/A cg15556689 chr8:8085844 FLJ10661 -0.51 -7.21 -0.37 3.68e-12 Monocyte count; LUSC cis rs12310956 0.532 rs11052951 chr12:33986181 T/A cg06521331 chr12:34319734 NA -0.44 -7.18 -0.37 4.6e-12 Morning vs. evening chronotype; LUSC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg21138405 chr5:131827807 IRF1 -0.34 -5.94 -0.31 7e-9 Breast cancer;Mosquito bite size; LUSC cis rs4975709 0.798 rs4975757 chr5:1882579 G/A cg15595755 chr5:1867978 NA 0.4 6.32 0.33 8.59e-10 Cardiovascular disease risk factors; LUSC cis rs10504073 0.669 rs341801 chr8:50037784 A/G cg00325661 chr8:49890786 NA 0.59 9.72 0.47 7.68e-20 Blood metabolite ratios; LUSC cis rs6977660 0.660 rs7357202 chr7:19817911 T/A cg05791153 chr7:19748676 TWISTNB 0.66 7.0 0.36 1.38e-11 Thyroid stimulating hormone; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg05025164 chr4:1340916 KIAA1530 0.65 10.61 0.5 7.18e-23 Longevity; LUSC cis rs1451375 1.000 rs1966839 chr7:50627101 T/C cg18232548 chr7:50535776 DDC 0.52 7.91 0.4 3.76e-14 Malaria; LUSC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg26695010 chr11:65641043 EFEMP2 -0.47 -7.2 -0.37 3.89e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.01e-30 Aortic root size; LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg25036284 chr2:26402008 FAM59B -0.74 -10.81 -0.51 1.52e-23 Gut microbiome composition (summer); LUSC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg06634786 chr22:41940651 POLR3H -0.53 -6.05 -0.31 3.88e-9 Vitiligo; LUSC trans rs6842047 1.000 rs9995366 chr4:187131384 T/C cg00427296 chr17:8534932 MYH10 -0.55 -5.98 -0.31 5.59e-9 Blood protein levels; LUSC cis rs2692947 0.800 rs61409777 chr2:96581373 C/A cg22654517 chr2:96458247 NA 0.38 7.62 0.38 2.6e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs6076960 0.652 rs3843045 chr20:6264593 C/T cg17788362 chr6:86352627 SYNCRIP -0.47 -7.24 -0.37 3.19e-12 Smooth-surface caries; LUSC cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg03934865 chr2:198174659 NA -0.34 -5.7 -0.3 2.7e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg09365446 chr1:150670422 GOLPH3L 0.48 7.12 0.36 6.85e-12 Melanoma; LUSC cis rs2996428 0.667 rs11576900 chr1:3770914 A/G cg13057898 chr1:3703894 LRRC47 0.49 8.63 0.43 2.55e-16 Red cell distribution width; LUSC cis rs7615952 1.000 rs7615952 chr3:125649403 A/C cg05084668 chr3:125655381 ALG1L 0.75 11.66 0.54 1.35e-26 Blood pressure (smoking interaction); LUSC trans rs1325195 0.537 rs3818433 chr1:179079190 C/T cg11624085 chr17:8464688 MYH10 0.46 6.93 0.35 2.17e-11 IgE grass sensitization; LUSC cis rs13392177 0.647 rs10932761 chr2:219064391 T/A cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.7 -0.3 2.66e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs10751667 0.666 rs7936830 chr11:959686 A/G ch.11.42038R chr11:967971 AP2A2 0.44 6.6 0.34 1.63e-10 Alzheimer's disease (late onset); LUSC cis rs34421088 0.548 rs2618443 chr8:11384556 A/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.74 -0.35 6.91e-11 Neuroticism; LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg08736216 chr1:53307985 ZYG11A -0.28 -5.72 -0.3 2.39e-8 Monocyte count; LUSC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.44 0.53 8.23e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs2295359 1.000 rs12043240 chr1:67624304 C/T cg17031739 chr1:67600172 NA 0.36 5.68 0.3 2.9e-8 Psoriasis; LUSC trans rs6502050 0.799 rs4789681 chr17:80100546 G/A cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg05585544 chr11:47624801 NA 0.4 7.01 0.36 1.33e-11 Subjective well-being; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20659025 chr11:126173961 DCPS -0.51 -6.08 -0.32 3.35e-9 Bipolar disorder and schizophrenia; LUSC cis rs9309711 0.922 rs13399524 chr2:3480206 C/G cg10845886 chr2:3471009 TTC15 -0.59 -7.67 -0.39 1.91e-13 Neurofibrillary tangles; LUSC cis rs8017423 0.586 rs2896134 chr14:90831293 G/A cg04374321 chr14:90722782 PSMC1 -0.41 -6.05 -0.31 3.79e-9 Mortality in heart failure; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg20887711 chr4:1340912 KIAA1530 -0.7 -11.84 -0.54 3.13e-27 Longevity; LUSC cis rs1023500 0.596 rs5751209 chr22:42451603 A/G cg04733989 chr22:42467013 NAGA 0.63 9.9 0.48 1.95e-20 Schizophrenia; LUSC cis rs12579753 0.917 rs76240969 chr12:82195236 C/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC trans rs60843830 1.000 rs56167434 chr2:282137 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 10.7 0.51 3.6e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9653442 0.675 rs961788 chr2:100641459 T/C cg07810366 chr2:100720526 AFF3 -0.42 -6.95 -0.36 1.89e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs62400317 0.859 rs4443508 chr6:45235952 C/T cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs17253792 0.822 rs10137364 chr14:56059987 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg11645453 chr3:52864694 ITIH4 0.3 6.87 0.35 3.17e-11 Electroencephalogram traits; LUSC cis rs7647973 0.769 rs6772452 chr3:49040462 A/G cg07636037 chr3:49044803 WDR6 0.94 13.32 0.59 9.25e-33 Menarche (age at onset); LUSC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg23649088 chr2:200775458 C2orf69 0.77 13.94 0.61 3.86e-35 Osteoporosis; LUSC cis rs2742417 0.603 rs2742455 chr3:45767116 A/G cg04837898 chr3:45731254 SACM1L -0.45 -7.26 -0.37 2.66e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11122272 0.735 rs2790886 chr1:231529491 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.21 -0.49 1.8e-21 Hemoglobin concentration; LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg25072359 chr17:41440525 NA 0.66 9.5 0.46 4.09e-19 Menopause (age at onset); LUSC trans rs7937682 0.632 rs10789850 chr11:111750829 C/T cg18187862 chr3:45730750 SACM1L -0.53 -6.45 -0.33 3.92e-10 Primary sclerosing cholangitis; LUSC cis rs9311676 0.632 rs62258126 chr3:58396114 T/C cg13750441 chr3:58318267 PXK 0.35 6.76 0.35 6.01e-11 Systemic lupus erythematosus; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07817097 chr1:179851575 TOR1AIP1 -0.52 -6.7 -0.34 9.14e-11 Bipolar disorder and schizophrenia; LUSC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg06484146 chr7:12443880 VWDE -0.7 -7.51 -0.38 5.55e-13 Coronary artery disease; LUSC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -8.49 -0.42 7.06e-16 Personality dimensions; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.42 -0.42 1.13e-15 Lymphocyte counts; LUSC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg08213375 chr14:104286397 PPP1R13B 0.44 7.68 0.39 1.78e-13 Reticulocyte count; LUSC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg12257692 chr3:49977190 RBM6 0.24 6.74 0.35 6.99e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg20607798 chr8:58055168 NA 0.52 5.66 0.3 3.33e-8 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg02569458 chr12:86230093 RASSF9 0.48 7.62 0.38 2.63e-13 Major depressive disorder; LUSC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg15605315 chr1:45957053 TESK2 0.46 7.19 0.37 4.38e-12 High light scatter reticulocyte count; LUSC cis rs1322512 1.000 rs1727054 chr6:152947742 A/G cg27316956 chr6:152958899 SYNE1 -0.33 -5.65 -0.3 3.45e-8 Tonometry; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.49 8.06 0.4 1.33e-14 Lymphocyte counts; LUSC cis rs11209002 0.738 rs1321154 chr1:67570703 T/C cg02640540 chr1:67518911 SLC35D1 0.67 6.68 0.34 9.71e-11 Crohn's disease; LUSC cis rs9393777 0.588 rs4518487 chr6:26467531 A/G cg12292205 chr6:26970375 C6orf41 -0.59 -7.2 -0.37 4.06e-12 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg21573476 chr21:45109991 RRP1B -0.37 -6.0 -0.31 5.14e-9 Mean corpuscular volume; LUSC cis rs7843479 0.965 rs11784535 chr8:21857787 G/A cg17168535 chr8:21777572 XPO7 0.65 9.71 0.47 8.7e-20 Mean corpuscular volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18013306 chr15:68521911 CLN6 0.44 6.08 0.32 3.24e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg07424592 chr7:64974309 NA 0.7 6.04 0.31 4.12e-9 Diabetic kidney disease; LUSC cis rs7945718 0.875 rs7924501 chr11:12813870 A/G cg25843174 chr11:12811716 TEAD1 0.34 7.63 0.39 2.48e-13 Educational attainment (years of education); LUSC trans rs10802346 0.545 rs1361408 chr1:246410054 T/G cg22732515 chr19:44031385 ETHE1 0.66 10.61 0.5 7.2e-23 Fractional exhaled nitric oxide (childhood); LUSC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg11247378 chr22:39784982 NA -0.62 -11.12 -0.52 1.17e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs12477438 0.834 rs1563107 chr2:99701276 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.79 11.31 0.53 2.58e-25 Chronic sinus infection; LUSC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg10482924 chr11:62539163 TAF6L 0.41 6.02 0.31 4.63e-9 Calcium levels; LUSC cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs4925386 0.808 rs1741634 chr20:60925979 A/C cg22601191 chr20:60968625 CABLES2 -0.39 -6.33 -0.33 8.08e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs4285028 0.747 rs7610298 chr3:121419100 T/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.97 -0.58 1.9e-31 Multiple sclerosis; LUSC cis rs11168351 1.000 rs11168351 chr12:48403765 C/T cg24011408 chr12:48396354 COL2A1 0.47 6.86 0.35 3.39e-11 Bipolar disorder and schizophrenia; LUSC cis rs4722585 0.533 rs6964215 chr7:26196819 G/A cg07876897 chr7:26191696 NFE2L3 0.46 6.91 0.35 2.49e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs4663866 1.000 rs13033501 chr2:239181860 G/A cg16914508 chr2:239161102 PER2 0.69 7.41 0.38 1.06e-12 Irritable bowel syndrome; LUSC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg14552801 chr7:65878734 NA 0.45 6.53 0.34 2.38e-10 Aortic root size; LUSC cis rs3736594 0.722 rs12993377 chr2:27952767 G/C cg27432699 chr2:27873401 GPN1 -0.63 -8.92 -0.44 3.06e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7408868 1.000 rs7249525 chr19:15277309 G/A cg14696996 chr19:15285081 NOTCH3 0.96 8.62 0.43 2.65e-16 Pulse pressure; LUSC cis rs1957429 0.572 rs3813421 chr14:65347239 G/A cg23373153 chr14:65346875 NA 1.08 12.76 0.57 1.22e-30 Pediatric areal bone mineral density (radius); LUSC cis rs12410462 0.681 rs113984727 chr1:227553917 C/A cg23173402 chr1:227635558 NA 0.54 6.27 0.32 1.11e-9 Major depressive disorder; LUSC cis rs6582630 0.638 rs12425379 chr12:38523705 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.54 -0.34 2.35e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7572733 0.555 rs1435569 chr2:198718667 G/C cg00792783 chr2:198669748 PLCL1 0.43 5.86 0.31 1.12e-8 Dermatomyositis; LUSC cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg21535247 chr6:8435926 SLC35B3 0.6 9.26 0.45 2.64e-18 Motion sickness; LUSC cis rs9517320 0.534 rs61971163 chr13:99188883 G/A cg20487152 chr13:99095054 FARP1 -0.42 -7.08 -0.36 8.66e-12 Longevity; LUSC cis rs10761482 0.861 rs4948406 chr10:62110146 G/T cg18175470 chr10:62150864 ANK3 -0.5 -7.04 -0.36 1.13e-11 Schizophrenia; LUSC cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg24558204 chr6:135376177 HBS1L 0.68 10.82 0.51 1.32e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7208859 0.623 rs73269988 chr17:29118145 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs614226 0.744 rs787832 chr12:120986801 A/G cg21053147 chr12:120880522 NA -0.49 -5.99 -0.31 5.35e-9 Type 1 diabetes nephropathy; LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs8062405 1.000 rs62037369 chr16:28883841 C/T cg05966235 chr16:28915196 ATP2A1 0.34 5.96 0.31 6.43e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs55665837 1.000 rs12287715 chr11:14444575 G/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg13047869 chr3:10149882 C3orf24 0.55 7.84 0.39 6.12e-14 Alzheimer's disease; LUSC cis rs7917772 0.545 rs10786681 chr10:104317357 G/T cg22532475 chr10:104410764 TRIM8 -0.26 -6.07 -0.32 3.42e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs929354 0.557 rs62491947 chr7:156960813 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.49 -0.46 4.49e-19 Body mass index; LUSC cis rs1008375 0.898 rs4698623 chr4:17594702 T/C cg18681998 chr4:17616180 MED28 0.84 15.29 0.64 2.24e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs992157 0.710 rs7569907 chr2:219070551 C/T cg00012203 chr2:219082015 ARPC2 0.87 16.55 0.67 2.36e-45 Colorectal cancer; LUSC cis rs1577917 0.958 rs13207354 chr6:86700263 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.31e-11 Response to antipsychotic treatment; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.67 0.39 1.94e-13 Prudent dietary pattern; LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.81e-12 Depression; LUSC cis rs11971779 0.590 rs6467839 chr7:139062790 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.0 0.36 1.38e-11 Diisocyanate-induced asthma; LUSC cis rs4595586 0.505 rs11613808 chr12:39390823 T/A cg26384229 chr12:38710491 ALG10B 0.53 7.53 0.38 4.83e-13 Morning vs. evening chronotype; LUSC trans rs853679 0.607 rs13211507 chr6:28257377 T/C cg01620082 chr3:125678407 NA -0.78 -7.6 -0.38 3.04e-13 Depression; LUSC cis rs8016982 0.531 rs2241622 chr14:81737290 A/G cg01989461 chr14:81687754 GTF2A1 0.51 6.24 0.32 1.33e-9 Schizophrenia; LUSC cis rs7091068 0.567 rs1572773 chr10:95432968 T/C cg20715218 chr10:95462985 C10orf4 0.46 5.83 0.3 1.32e-8 Urinary tract infection frequency; LUSC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg03676636 chr4:99064102 C4orf37 -0.34 -7.49 -0.38 6.14e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10892173 0.566 rs10892175 chr11:117674355 G/A cg07621104 chr11:117668040 DSCAML1 0.46 6.09 0.32 3.09e-9 Myopia; LUSC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.74 0.51 2.64e-23 Homoarginine levels; LUSC cis rs9788682 1.000 rs61204066 chr15:78815298 G/A cg06917634 chr15:78832804 PSMA4 -0.59 -7.31 -0.37 1.97e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs929843 1 rs929843 chr16:70045748 A/C cg00158530 chr16:69966973 MIR140;WWP2 -0.44 -7.0 -0.36 1.4e-11 Menarche (age at onset); LUSC cis rs708547 0.647 rs1403233 chr4:57885053 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.51 -7.19 -0.37 4.18e-12 Response to bleomycin (chromatid breaks); LUSC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg20203395 chr5:56204925 C5orf35 -0.72 -9.9 -0.48 1.96e-20 Initial pursuit acceleration; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.37 0.37 1.32e-12 Bipolar disorder; LUSC cis rs506338 0.517 rs17146216 chr11:64451281 C/G cg19131476 chr11:64387923 NRXN2 0.38 8.22 0.41 4.43e-15 Body mass index;Urate levels; LUSC cis rs9788721 0.775 rs8040868 chr15:78911181 C/T cg18825076 chr15:78729989 IREB2 0.52 8.81 0.43 6.82e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs17255340 0.577 rs6937273 chr6:84095513 A/G cg08257003 chr6:84140564 ME1 0.34 8.31 0.41 2.41e-15 Platelet-derived growth factor BB levels; LUSC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg22875332 chr1:76189707 ACADM 0.85 15.63 0.65 1.01e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg06873352 chr17:61820015 STRADA 0.71 12.8 0.57 8.38e-31 Prudent dietary pattern; LUSC trans rs62103177 0.810 rs62103187 chr18:77627633 G/C cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg23711669 chr6:146136114 FBXO30 0.87 15.55 0.65 2.07e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg22508957 chr16:3507546 NAT15 -0.41 -5.84 -0.3 1.25e-8 Body mass index (adult); LUSC cis rs861020 0.606 rs627459 chr1:210004682 C/G cg05527609 chr1:210001259 C1orf107 0.7 10.07 0.48 5.22e-21 Orofacial clefts; LUSC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC cis rs6598955 0.671 rs11247884 chr1:26577338 C/T cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.47 -0.38 7.12e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7589342 0.929 rs13024715 chr2:106433950 A/G cg14210321 chr2:106509881 NCK2 -0.54 -8.12 -0.41 9.28e-15 Addiction; LUSC cis rs7568458 0.905 rs6714709 chr2:85756375 C/G cg23752985 chr2:85803571 VAMP8 0.34 7.3 0.37 2.16e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg24675658 chr1:53192096 ZYG11B -0.58 -8.84 -0.44 5.68e-17 Monocyte count; LUSC cis rs6964587 0.610 rs4729008 chr7:91457054 G/T cg17063962 chr7:91808500 NA 0.53 8.62 0.43 2.76e-16 Breast cancer; LUSC cis rs644148 0.836 rs2571112 chr19:45000319 T/A cg15540054 chr19:45004280 ZNF180 -0.63 -9.35 -0.46 1.3e-18 Personality dimensions; LUSC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg11301795 chr4:187892539 NA -0.79 -15.28 -0.64 2.53e-40 Lobe attachment (rater-scored or self-reported); LUSC trans rs6952808 0.929 rs34145223 chr7:1926237 G/A cg04565464 chr8:145669602 NFKBIL2 0.39 6.43 0.33 4.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg26695010 chr11:65641043 EFEMP2 0.4 5.65 0.3 3.53e-8 Breast cancer; LUSC cis rs2361710 0.611 rs3816257 chr17:78074446 G/T cg09238746 chr17:78121135 EIF4A3 0.42 5.92 0.31 7.84e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs1371867 0.764 rs1020171 chr8:101288610 T/C cg06636551 chr8:101224915 SPAG1 -0.45 -8.22 -0.41 4.52e-15 Atrioventricular conduction; LUSC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.92 -13.28 -0.59 1.3e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1957429 0.614 rs73279812 chr14:65348012 G/A cg23373153 chr14:65346875 NA -1.03 -9.4 -0.46 8.72e-19 Pediatric areal bone mineral density (radius); LUSC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg22508957 chr16:3507546 NAT15 -0.39 -6.12 -0.32 2.68e-9 Body mass index (adult); LUSC cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg06212747 chr3:49208901 KLHDC8B 0.53 7.29 0.37 2.22e-12 Parkinson's disease; LUSC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4595586 0.679 rs5017082 chr12:39314564 A/C cg26384229 chr12:38710491 ALG10B -0.43 -5.88 -0.31 9.69e-9 Morning vs. evening chronotype; LUSC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg16049864 chr8:95962084 TP53INP1 -0.38 -6.54 -0.34 2.25e-10 Alzheimer's disease (late onset); LUSC cis rs453301 0.631 rs13250781 chr8:8793343 T/G cg15556689 chr8:8085844 FLJ10661 -0.62 -9.85 -0.47 2.82e-20 Joint mobility (Beighton score); LUSC cis rs2742417 0.603 rs2742455 chr3:45767116 A/G cg10512202 chr3:45649293 LIMD1 0.36 5.93 0.31 7.48e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6736093 0.966 rs11683694 chr2:112702647 C/T cg12686935 chr2:112915763 FBLN7 -0.36 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs911555 0.755 rs8016676 chr14:103904842 C/A cg12935359 chr14:103987150 CKB 0.66 10.81 0.51 1.43e-23 Intelligence (multi-trait analysis); LUSC trans rs11246602 1 rs11246602 chr11:51512090 T/C cg15704280 chr7:45808275 SEPT13 0.89 7.74 0.39 1.21e-13 HDL cholesterol levels;HDL cholesterol; LUSC cis rs2228479 0.541 rs9806913 chr16:89953773 A/G cg06558623 chr16:89946397 TCF25 0.95 10.21 0.49 1.82e-21 Skin colour saturation; LUSC cis rs10875746 0.951 rs4760689 chr12:48563644 G/A cg13454099 chr12:49076203 C12orf41 -0.51 -5.95 -0.31 6.91e-9 Longevity (90 years and older); LUSC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg12310025 chr6:25882481 NA -0.46 -8.01 -0.4 1.91e-14 Intelligence (multi-trait analysis); LUSC cis rs727505 0.583 rs17147421 chr7:124383948 C/T cg23710748 chr7:124431027 NA -0.33 -5.82 -0.3 1.39e-8 Lewy body disease; LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg22963979 chr7:1858916 MAD1L1 -0.5 -7.65 -0.39 2.19e-13 Bipolar disorder and schizophrenia; LUSC cis rs79349575 0.870 rs12941262 chr17:46967037 T/A cg22482690 chr17:47019901 SNF8 0.4 7.47 0.38 7e-13 Type 2 diabetes; LUSC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg04398451 chr17:18023971 MYO15A 0.57 9.44 0.46 6.61e-19 Total body bone mineral density; LUSC cis rs12549902 0.871 rs4736819 chr8:41509915 C/T cg21772509 chr8:41503840 NKX6-3 0.66 10.91 0.51 6.84e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs7296418 0.961 rs4275659 chr12:123447928 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.34 6.34 0.33 7.52e-10 Platelet count; LUSC cis rs6696846 0.791 rs11240352 chr1:205051711 C/G cg21643547 chr1:205240462 TMCC2 0.42 7.66 0.39 2e-13 Red blood cell count; LUSC cis rs870825 0.616 rs28608669 chr4:185632890 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.2 0.59 2.54e-32 Blood protein levels; LUSC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6987853 0.966 rs2974338 chr8:42391945 A/G cg09913449 chr8:42400586 C8orf40 0.49 8.3 0.41 2.56e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs2857891 0.697 rs4757980 chr11:6921840 G/T cg04053776 chr11:6947353 ZNF215 0.56 7.94 0.4 3.02e-14 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg16680214 chr1:154839983 KCNN3 -0.52 -9.76 -0.47 5.77e-20 Prostate cancer; LUSC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg21545522 chr1:205238299 TMCC2 0.49 9.16 0.45 5.45e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4594175 0.926 rs7493621 chr14:51623665 C/T cg23942311 chr14:51606299 NA 0.32 6.03 0.31 4.28e-9 Cancer; LUSC cis rs9467773 0.620 rs2494696 chr6:26620894 A/G cg05738196 chr6:26577821 NA 0.79 15.24 0.64 3.59e-40 Intelligence (multi-trait analysis); LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 4.92e-10 Systemic lupus erythematosus; LUSC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg22834771 chr12:69754056 YEATS4 -0.44 -6.63 -0.34 1.39e-10 Blood protein levels; LUSC cis rs2011503 0.509 rs11668721 chr19:19760916 G/A cg11584989 chr19:19387371 SF4 0.51 5.74 0.3 2.14e-8 Bipolar disorder; LUSC cis rs9300255 0.722 rs28592876 chr12:123866429 G/A cg13010344 chr12:123464640 ARL6IP4 0.51 6.5 0.33 2.97e-10 Neutrophil percentage of white cells; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg15462925 chr8:12613305 LONRF1 0.37 6.1 0.32 2.94e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs72781680 0.898 rs72796158 chr2:23935727 T/C cg08917208 chr2:24149416 ATAD2B 1.0 10.16 0.49 2.55e-21 Lymphocyte counts; LUSC cis rs9868809 0.505 rs13063223 chr3:48750340 G/A cg00383909 chr3:49044727 WDR6 1.14 10.58 0.5 9.36e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs4629710 0.592 rs749375 chr6:131553692 C/G cg12606694 chr6:131520996 AKAP7 0.63 9.57 0.46 2.46e-19 Multiple myeloma (IgH translocation); LUSC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg27266027 chr21:40555129 PSMG1 0.4 5.91 0.31 8.64e-9 Cognitive function; LUSC trans rs11098499 0.954 rs6848389 chr4:120402622 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.69 0.34 9.42e-11 Corneal astigmatism; LUSC cis rs35995292 0.534 rs2008199 chr7:38939678 T/C cg19327137 chr7:38886074 VPS41 0.54 10.18 0.49 2.18e-21 Subjective well-being (multi-trait analysis); LUSC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 9.44 0.46 6.68e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg15445000 chr17:37608096 MED1 -0.38 -6.61 -0.34 1.53e-10 Glomerular filtration rate (creatinine); LUSC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg17143192 chr8:8559678 CLDN23 0.65 9.49 0.46 4.57e-19 Obesity-related traits; LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg00431813 chr7:1051703 C7orf50 -0.43 -7.32 -0.37 1.9e-12 Longevity;Endometriosis; LUSC cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC trans rs9388451 0.874 rs1159974 chr6:126090277 C/T cg05039488 chr6:79577232 IRAK1BP1 0.56 9.02 0.44 1.53e-17 Brugada syndrome; LUSC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg06022373 chr22:39101656 GTPBP1 0.8 12.42 0.56 2.15e-29 Menopause (age at onset); LUSC trans rs4911259 0.552 rs13038017 chr20:31467551 T/C cg09781936 chr22:19749961 TBX1 -0.33 -5.95 -0.31 6.84e-9 Inflammatory bowel disease; LUSC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.78 0.39 9.24e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7945705 0.791 rs4579928 chr11:8815704 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.31 6.46 0.33 3.64e-10 Hemoglobin concentration; LUSC cis rs7903847 0.642 rs10786341 chr10:99158607 G/A cg20016023 chr10:99160130 RRP12 -0.32 -7.98 -0.4 2.38e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs9303401 0.659 rs72828726 chr17:56951217 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.36 0.59 6.42e-33 Cognitive test performance; LUSC cis rs7582180 0.591 rs11674569 chr2:101010860 G/A cg12002119 chr2:101014098 CHST10 0.36 6.06 0.31 3.77e-9 Intelligence (multi-trait analysis); LUSC cis rs17433780 0.964 rs10493821 chr1:89475135 C/T cg09516651 chr1:89888402 LOC400759 0.52 8.62 0.43 2.81e-16 Carotid intima media thickness; LUSC trans rs11088226 0.581 rs2833860 chr21:33882309 G/A cg09050820 chr6:167586206 TCP10L2 0.47 7.1 0.36 7.49e-12 Gastritis; LUSC cis rs10743315 0.557 rs74974316 chr12:19344688 A/G cg02471346 chr12:19282374 PLEKHA5 0.69 5.74 0.3 2.09e-8 Gut microbiota (bacterial taxa); LUSC trans rs230489 0.668 rs13129951 chr4:103374760 G/A cg20368818 chr11:33800056 NA -0.46 -5.99 -0.31 5.42e-9 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg11764359 chr7:65958608 NA 0.81 13.55 0.6 1.19e-33 Aortic root size; LUSC cis rs34526934 0.608 rs72927183 chr2:177033779 C/T cg26754761 chr2:177040938 NA -0.39 -7.55 -0.38 4.22e-13 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs8013055 0.846 rs8013827 chr14:105970176 C/T cg23356831 chr14:105996513 TMEM121 -0.3 -5.73 -0.3 2.29e-8 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs4253772 0.872 rs79700435 chr22:46638211 G/A cg24881330 chr22:46731750 TRMU 0.63 5.79 0.3 1.61e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg15649852 chr7:65879115 NA 0.41 5.79 0.3 1.64e-8 Aortic root size; LUSC cis rs826838 0.935 rs1601579 chr12:39178606 G/C cg26384229 chr12:38710491 ALG10B 0.89 16.94 0.68 7.06e-47 Heart rate; LUSC cis rs6546550 0.901 rs6741449 chr2:70156589 A/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.22e-12 Prevalent atrial fibrillation; LUSC cis rs7575217 0.921 rs2871393 chr2:101770430 C/G cg23907051 chr2:101730305 TBC1D8 -0.29 -7.51 -0.38 5.34e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC trans rs2797160 1.000 rs2747723 chr6:126010790 C/T cg05039488 chr6:79577232 IRAK1BP1 0.47 6.98 0.36 1.61e-11 Endometrial cancer; LUSC cis rs2953174 0.720 rs2975794 chr2:241515813 C/T cg07929629 chr2:241523174 NA 0.51 7.84 0.39 5.94e-14 Bipolar disorder; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg12646754 chr1:2574751 NA 0.37 6.07 0.32 3.57e-9 Triglycerides; LUSC cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg18681998 chr4:17616180 MED28 0.77 13.66 0.6 4.65e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9325144 0.555 rs4882358 chr12:38726640 A/G cg26384229 chr12:38710491 ALG10B 0.6 9.48 0.46 4.8e-19 Morning vs. evening chronotype; LUSC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg11608241 chr8:8085544 FLJ10661 0.41 5.7 0.3 2.59e-8 Mean corpuscular volume; LUSC trans rs17507216 1.000 rs17507216 chr15:83226925 A/G cg04831495 chr15:85060580 GOLGA6L5 0.44 6.1 0.32 2.91e-9 Excessive daytime sleepiness; LUSC cis rs7267979 0.903 rs2500423 chr20:25374882 G/A cg08601574 chr20:25228251 PYGB -0.43 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2078087 0.522 rs7525417 chr1:183211052 G/A cg13843938 chr1:183241246 NMNAT2 0.46 6.67 0.34 1.03e-10 Obesity-related traits; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg11843238 chr5:131593191 PDLIM4 0.5 8.66 0.43 2.06e-16 Acylcarnitine levels; LUSC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.7 0.34 8.97e-11 Tonsillectomy; LUSC trans rs17301259 0.662 rs2718304 chr7:88391758 T/C cg21771463 chr3:44626400 ZNF660 -0.38 -6.16 -0.32 2.13e-9 Heschl's gyrus morphology; LUSC cis rs6456156 0.586 rs1407315 chr6:167468659 A/G cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg16447950 chr5:562315 NA -0.54 -6.59 -0.34 1.76e-10 Obesity-related traits; LUSC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg00677455 chr12:58241039 CTDSP2 0.61 8.47 0.42 7.68e-16 Multiple sclerosis; LUSC cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.59 -0.38 3.21e-13 Personality dimensions; LUSC trans rs57221529 0.766 rs12522303 chr5:555564 A/C cg11887960 chr12:57824829 NA 0.55 7.21 0.37 3.7e-12 Lung disease severity in cystic fibrosis; LUSC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg04362960 chr10:104952993 NT5C2 0.59 9.39 0.46 1e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg08470875 chr2:26401718 FAM59B -0.69 -9.49 -0.46 4.53e-19 Gut microbiome composition (summer); LUSC trans rs7824557 0.815 rs2572430 chr8:11105304 G/T cg06636001 chr8:8085503 FLJ10661 0.49 6.94 0.36 2.01e-11 Retinal vascular caliber; LUSC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg26597838 chr10:835615 NA 0.99 13.75 0.6 2.12e-34 Eosinophil percentage of granulocytes; LUSC cis rs11971779 0.616 rs7784192 chr7:139039649 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6062509 0.839 rs6062298 chr20:62301970 G/A cg27236539 chr20:62289627 RTEL1 0.49 6.62 0.34 1.43e-10 Prostate cancer; LUSC cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg09184832 chr6:79620586 NA -0.44 -7.07 -0.36 8.88e-12 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg06784218 chr1:46089804 CCDC17 0.54 10.91 0.51 6.6e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.53 -0.38 4.89e-13 Aortic root size; LUSC cis rs7428496 0.528 rs13068397 chr3:142294425 A/C cg16271453 chr3:142027066 XRN1 -0.49 -8.44 -0.42 9.81e-16 Mean corpuscular hemoglobin; LUSC cis rs10779751 1.000 rs11121710 chr1:11313244 T/C cg08854313 chr1:11322531 MTOR 0.87 14.89 0.63 7.85e-39 Body mass index; LUSC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.77 0.35 5.68e-11 Tonsillectomy; LUSC cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg18681998 chr4:17616180 MED28 -0.82 -13.88 -0.6 6.84e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1113500 0.933 rs11185261 chr1:108638703 G/A cg06207961 chr1:108661230 NA 0.41 7.64 0.39 2.29e-13 Growth-regulated protein alpha levels; LUSC cis rs9527 0.590 rs1926037 chr10:104878010 A/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs921968 0.565 rs11896209 chr2:219599268 C/T cg02176678 chr2:219576539 TTLL4 -0.56 -9.63 -0.47 1.53e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC trans rs2980439 0.556 rs2921059 chr8:8317887 G/T cg21775007 chr8:11205619 TDH 0.42 6.14 0.32 2.39e-9 Neuroticism; LUSC cis rs7824557 0.767 rs3808509 chr8:11163256 G/T cg27411982 chr8:10470053 RP1L1 0.38 5.9 0.31 8.94e-9 Retinal vascular caliber; LUSC cis rs6977660 0.653 rs28537170 chr7:19814239 T/G cg07541023 chr7:19748670 TWISTNB 0.75 7.66 0.39 1.96e-13 Thyroid stimulating hormone; LUSC cis rs6084875 0.840 rs2422942 chr20:4726116 A/G cg07258627 chr20:4721683 PRNT -0.34 -6.16 -0.32 2.05e-9 Systemic lupus erythematosus; LUSC cis rs2970818 0.831 rs7304949 chr12:4609625 A/G cg11146114 chr12:4671731 NA -0.58 -6.21 -0.32 1.61e-9 Phosphorus levels; LUSC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg18681998 chr4:17616180 MED28 0.84 15.63 0.65 1.03e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3770081 1.000 rs2118521 chr2:86204379 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -0.99 -6.65 -0.34 1.2e-10 Facial emotion recognition (sad faces); LUSC cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg13798780 chr7:105162888 PUS7 0.54 6.06 0.31 3.67e-9 Bipolar disorder (body mass index interaction); LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg11494091 chr17:61959527 GH2 0.66 13.94 0.61 3.9e-35 Prudent dietary pattern; LUSC cis rs500891 0.525 rs7768456 chr6:84054779 C/T cg08257003 chr6:84140564 ME1 0.32 7.08 0.36 8.45e-12 Platelet-derived growth factor BB levels; LUSC cis rs1559088 0.600 rs10421769 chr19:33605312 T/C cg27124370 chr19:33622961 WDR88 0.56 7.89 0.4 4.25e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.62 0.43 2.69e-16 Prudent dietary pattern; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg00945038 chr17:61921165 SMARCD2 0.52 8.8 0.43 7.26e-17 Prudent dietary pattern; LUSC cis rs5753618 0.583 rs5753632 chr22:31863097 C/T cg02404636 chr22:31891804 SFI1 0.45 6.62 0.34 1.43e-10 Colorectal cancer; LUSC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg15445000 chr17:37608096 MED1 0.38 6.53 0.34 2.52e-10 Glomerular filtration rate (creatinine); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26907351 chr6:2765585 WRNIP1 -0.42 -5.98 -0.31 5.74e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3126085 0.825 rs11204933 chr1:152172185 C/T cg03465714 chr1:152285911 FLG -0.41 -5.78 -0.3 1.71e-8 Atopic dermatitis; LUSC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg04369109 chr6:150039330 LATS1 -0.57 -8.39 -0.42 1.35e-15 Lung cancer; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.03 0.77 4.68e-67 Prudent dietary pattern; LUSC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.09e-30 Aortic root size; LUSC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs35146811 0.735 rs2272345 chr7:99797031 C/G cg13334819 chr7:99746414 C7orf59 -0.51 -6.9 -0.35 2.61e-11 Coronary artery disease; LUSC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg09365446 chr1:150670422 GOLPH3L 0.48 6.93 0.35 2.18e-11 Melanoma; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg27284194 chr4:1044797 NA 0.35 5.85 0.31 1.15e-8 Obesity-related traits; LUSC cis rs61931739 0.963 rs59195137 chr12:34091838 G/A cg06521331 chr12:34319734 NA 0.38 6.26 0.32 1.17e-9 Morning vs. evening chronotype; LUSC cis rs9325144 0.647 rs35254764 chr12:39102928 T/C cg13010199 chr12:38710504 ALG10B -0.52 -7.94 -0.4 3.03e-14 Morning vs. evening chronotype; LUSC cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg03146154 chr1:46216737 IPP 0.57 8.55 0.42 4.4e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3771570 1.000 rs59536819 chr2:242272388 A/G cg21155796 chr2:242212141 HDLBP 0.63 6.86 0.35 3.32e-11 Prostate cancer; LUSC cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.18 -0.45 4.78e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7267979 0.932 rs449370 chr20:25451180 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.9 -20.73 -0.75 5.85e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11785400 0.963 rs9771845 chr8:143726577 C/G cg10596483 chr8:143751796 JRK 0.61 9.37 0.46 1.1e-18 Schizophrenia; LUSC cis rs7804356 1.000 rs10486478 chr7:26819465 C/T cg03456212 chr7:26904342 SKAP2 -0.55 -6.49 -0.33 3.03e-10 Type 1 diabetes; LUSC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.45 0.33 3.89e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18099408 chr3:52552593 STAB1 -0.41 -6.95 -0.36 1.97e-11 Bipolar disorder; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg07167872 chr1:205819463 PM20D1 0.88 17.15 0.68 1.03e-47 Menarche (age at onset); LUSC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.52 -0.38 4.99e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.92 0.68 7.95e-47 Gut microbiome composition (summer); LUSC cis rs7937682 0.587 rs611607 chr11:111349765 C/T cg09085632 chr11:111637200 PPP2R1B -0.52 -7.17 -0.37 4.83e-12 Primary sclerosing cholangitis; LUSC cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg05294307 chr14:35346193 BAZ1A -0.58 -6.65 -0.34 1.23e-10 Psoriasis; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg13047869 chr3:10149882 C3orf24 0.62 8.87 0.44 4.43e-17 Alzheimer's disease; LUSC trans rs7819412 0.745 rs2898260 chr8:10939490 G/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.51 -0.34 2.83e-10 Triglycerides; LUSC cis rs1044826 0.642 rs295479 chr3:139223865 C/T cg00490450 chr3:139108681 COPB2 0.46 7.02 0.36 1.27e-11 Obesity-related traits; LUSC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg20243544 chr17:37824526 PNMT 0.43 6.54 0.34 2.28e-10 Self-reported allergy; LUSC cis rs3096299 0.685 rs4785568 chr16:89553707 A/G cg00750074 chr16:89608354 SPG7 -0.57 -10.39 -0.49 4.33e-22 Multiple myeloma (IgH translocation); LUSC cis rs921665 0.831 rs3887811 chr2:3182777 A/G cg02624386 chr2:3182749 NA 0.57 6.31 0.33 8.85e-10 World class endurance athleticism; LUSC cis rs7267979 1.000 rs2500432 chr20:25290512 A/C cg08601574 chr20:25228251 PYGB 0.38 5.66 0.3 3.26e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7760535 1.000 rs7760535 chr6:111747083 C/G cg22127309 chr6:111907043 TRAF3IP2 0.35 6.44 0.33 4.22e-10 Metabolic traits; LUSC cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1018836 0.923 rs6989123 chr8:91551234 A/T cg16814680 chr8:91681699 NA -0.77 -13.25 -0.59 1.69e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs61931739 0.649 rs12424046 chr12:33714374 C/T cg26384229 chr12:38710491 ALG10B -0.42 -6.17 -0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs2290416 0.892 rs77370907 chr8:144664975 G/C cg26536354 chr8:144654954 C8orf73 0.64 7.31 0.37 2e-12 Attention deficit hyperactivity disorder; LUSC cis rs7212590 0.748 rs7223057 chr17:57936438 G/C cg10252138 chr17:58120427 NA -0.73 -7.06 -0.36 9.79e-12 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs66569888 0.789 rs1317569 chr2:106735490 C/A cg15412446 chr2:106886593 NA -0.51 -6.32 -0.33 8.2e-10 Facial morphology (factor 23); LUSC cis rs7091068 0.754 rs1326224 chr10:95459267 C/T cg20715218 chr10:95462985 C10orf4 0.62 7.25 0.37 2.98e-12 Urinary tract infection frequency; LUSC cis rs7937682 0.575 rs7107213 chr11:111750430 A/G cg09085632 chr11:111637200 PPP2R1B 0.96 13.58 0.6 9.66e-34 Primary sclerosing cholangitis; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg16606324 chr3:10149918 C3orf24 0.6 8.0 0.4 2.03e-14 Alzheimer's disease; LUSC cis rs4566357 0.615 rs10190621 chr2:227914484 A/G cg11843606 chr2:227700838 RHBDD1 -0.52 -8.06 -0.4 1.35e-14 Coronary artery disease; LUSC cis rs12594515 1.000 rs8039622 chr15:45986431 A/G cg06207120 chr15:45996521 NA 0.4 6.07 0.32 3.54e-9 Waist circumference;Weight; LUSC cis rs7100689 0.577 rs2185427 chr10:82056667 G/T cg01528321 chr10:82214614 TSPAN14 -0.9 -13.51 -0.59 1.77e-33 Post bronchodilator FEV1; LUSC trans rs2204008 0.592 rs2320501 chr12:38145285 T/G cg06521331 chr12:34319734 NA -0.4 -6.16 -0.32 2.09e-9 Bladder cancer; LUSC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.15 -0.32 2.16e-9 Total body bone mineral density; LUSC cis rs2806561 0.704 rs2806570 chr1:23527005 C/T cg12483005 chr1:23474871 LUZP1 -0.47 -7.44 -0.38 8.82e-13 Height; LUSC cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 8.21 0.41 4.78e-15 Iron status biomarkers; LUSC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg00343986 chr7:65444356 GUSB 0.46 6.79 0.35 5.07e-11 Aortic root size; LUSC cis rs7586879 0.609 rs7608976 chr2:25075281 G/A cg15423357 chr2:25149977 NA 0.33 6.42 0.33 4.57e-10 Body mass index; LUSC cis rs9902453 0.791 rs7219163 chr17:28210703 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.38 0.53 1.44e-25 Coffee consumption (cups per day); LUSC cis rs826838 0.967 rs826856 chr12:39115434 G/A cg13010199 chr12:38710504 ALG10B -0.63 -10.87 -0.51 9.13e-24 Heart rate; LUSC cis rs7605827 0.897 rs11885852 chr2:15515371 A/C cg19274914 chr2:15703543 NA 0.47 9.05 0.44 1.19e-17 Educational attainment (years of education); LUSC cis rs600626 0.636 rs11236516 chr11:75451668 C/T cg24262691 chr11:75473276 NA -0.54 -6.9 -0.35 2.63e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1941023 0.584 rs2014121 chr11:60156297 T/C cg08716584 chr11:60157161 MS4A7 -0.65 -12.38 -0.56 3.12e-29 Congenital heart disease (maternal effect); LUSC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs7809950 1.000 rs7786801 chr7:107085889 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.86 -0.44 4.92e-17 Coronary artery disease; LUSC cis rs7193541 0.965 rs7184423 chr16:74709737 C/A cg01733217 chr16:74700730 RFWD3 0.87 14.86 0.63 1.09e-38 Multiple myeloma; LUSC cis rs17621444 0.522 rs4288683 chr10:121814553 C/T cg02041677 chr10:121771263 NA -0.33 -6.31 -0.33 8.94e-10 IgG glycosylation; LUSC cis rs1023500 0.551 rs133379 chr22:42468535 A/G cg15557168 chr22:42548783 NA -0.42 -6.26 -0.32 1.17e-9 Schizophrenia; LUSC cis rs926938 0.527 rs360667 chr1:115481451 C/G cg12756093 chr1:115239321 AMPD1 -0.45 -6.84 -0.35 3.89e-11 Autism; LUSC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg14829155 chr15:31115871 NA 0.71 10.81 0.51 1.49e-23 Huntington's disease progression; LUSC trans rs208520 0.837 rs208486 chr6:66926255 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -14.09 -0.61 1.04e-35 Exhaled nitric oxide output; LUSC cis rs9653442 0.564 rs10175599 chr2:100787635 C/T cg07810366 chr2:100720526 AFF3 -0.43 -7.28 -0.37 2.43e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6424115 0.708 rs34570472 chr1:24191720 A/G cg15997130 chr1:24165203 NA -0.48 -7.17 -0.37 4.82e-12 Immature fraction of reticulocytes; LUSC trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg03929089 chr4:120376271 NA -0.55 -6.81 -0.35 4.54e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg07677032 chr17:61819896 STRADA 0.54 8.95 0.44 2.46e-17 Prudent dietary pattern; LUSC trans rs3733585 0.673 rs6814664 chr4:9956228 C/T cg26043149 chr18:55253948 FECH -0.45 -7.02 -0.36 1.23e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs16949788 1.000 rs74521803 chr15:66832261 T/G cg08120210 chr15:66682733 MAP2K1 -0.61 -6.28 -0.33 1.04e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9814567 0.963 rs9844537 chr3:134238341 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.28 -0.59 1.35e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg21361702 chr7:150065534 REPIN1 0.48 6.24 0.32 1.35e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs148387471 1 rs148387471 chr3:127057551 ATAG/A cg20920097 chr3:127057149 NA -0.45 -6.4 -0.33 5.4e-10 Interleukin-10 levels;Interleukin-13 levels; LUSC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg16339924 chr4:17578868 LAP3 0.57 8.63 0.43 2.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg16362232 chr11:430036 ANO9 0.73 9.04 0.44 1.27e-17 Body mass index; LUSC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.82 0.6 1.14e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs9886428 1.000 rs2059671 chr8:14116229 C/G cg11959399 chr20:741723 C20orf54 -0.4 -6.45 -0.33 3.98e-10 IgG glycosylation; LUSC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg21951975 chr1:209979733 IRF6 0.59 7.89 0.4 4.46e-14 Cleft lip with or without cleft palate; LUSC cis rs78707713 0.560 rs61848398 chr10:71226103 G/A cg14388049 chr10:71211838 TSPAN15 -0.32 -5.82 -0.3 1.35e-8 Venous thromboembolism; LUSC cis rs73110464 0.505 rs2638503 chr12:53307369 C/G cg14581129 chr12:53358946 NA -0.34 -5.64 -0.3 3.56e-8 Cancer (pleiotropy); LUSC cis rs859767 0.519 rs6707326 chr2:135357705 G/A cg12500956 chr2:135428796 TMEM163 -0.26 -6.13 -0.32 2.54e-9 Neuroticism; LUSC cis rs4660306 0.961 rs1337902 chr1:45952066 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.09 -0.36 8.29e-12 Homocysteine levels; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg16688031 chr5:139091012 NA 0.37 6.16 0.32 2.04e-9 Metabolite levels (Pyroglutamine); LUSC cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg03146154 chr1:46216737 IPP -0.5 -7.15 -0.36 5.41e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs208520 0.690 rs12192851 chr6:66705862 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.06 16.59 0.67 1.7e-45 Exhaled nitric oxide output; LUSC cis rs950169 0.922 rs8037078 chr15:84818871 A/G cg12863693 chr15:85201151 NMB -0.36 -7.4 -0.38 1.11e-12 Schizophrenia; LUSC cis rs3764021 0.870 rs11052710 chr12:9876350 C/T cg20894963 chr12:9885564 CLECL1 0.34 7.06 0.36 9.92e-12 Type 1 diabetes; LUSC cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg16262614 chr3:133464971 TF 0.42 7.19 0.37 4.31e-12 Iron status biomarkers (transferrin levels); LUSC cis rs754466 0.606 rs11002315 chr10:79617385 T/G cg17075019 chr10:79541650 NA -0.74 -11.82 -0.54 3.48e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11039798 0.841 rs7294179 chr11:48765408 G/A cg15704280 chr7:45808275 SEPT13 0.85 7.23 0.37 3.39e-12 Axial length; LUSC trans rs61931739 0.500 rs11053236 chr12:34507962 C/G cg26384229 chr12:38710491 ALG10B 0.9 15.57 0.65 1.71e-41 Morning vs. evening chronotype; LUSC cis rs17490626 0.568 rs2033371 chr10:71212310 G/A cg14388049 chr10:71211838 TSPAN15 -0.33 -6.07 -0.32 3.56e-9 Thrombosis; LUSC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg13939156 chr17:80058883 NA -0.34 -6.68 -0.34 9.9e-11 Life satisfaction; LUSC trans rs72674100 1.000 rs7689769 chr4:97968142 G/A cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg09021430 chr5:549028 NA -0.57 -8.59 -0.43 3.4e-16 Obesity-related traits; LUSC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg05368731 chr17:41323189 NBR1 0.83 13.62 0.6 6.85e-34 Menopause (age at onset); LUSC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg15605315 chr1:45957053 TESK2 0.46 7.54 0.38 4.53e-13 High light scatter reticulocyte count; LUSC cis rs950776 0.518 rs55690619 chr15:78833612 A/G cg22563815 chr15:78856949 CHRNA5 -0.26 -6.2 -0.32 1.65e-9 Sudden cardiac arrest; LUSC cis rs7100689 0.577 rs1143694 chr10:82040052 C/T cg00277334 chr10:82204260 NA 0.45 6.55 0.34 2.16e-10 Post bronchodilator FEV1; LUSC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg12927641 chr6:109611667 NA -0.43 -7.49 -0.38 6.13e-13 Reticulocyte fraction of red cells; LUSC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.96 0.55 1.14e-27 Personality dimensions; LUSC cis rs9790314 0.502 rs34972965 chr3:160984296 G/A cg03342759 chr3:160939853 NMD3 -0.55 -8.04 -0.4 1.62e-14 Morning vs. evening chronotype; LUSC cis rs2285947 1.000 rs2285949 chr7:21584243 G/A cg04471919 chr7:21584483 DNAH11 0.34 7.73 0.39 1.29e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC trans rs10435719 0.580 rs13260712 chr8:11782570 A/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.41 -0.33 5.05e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs11018904 0.906 rs35129016 chr11:89948689 T/C cg26138821 chr11:89956704 CHORDC1 -0.59 -6.82 -0.35 4.4e-11 Intelligence (multi-trait analysis); LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg13397359 chr6:42928475 GNMT 0.65 11.11 0.52 1.29e-24 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg03036452 chr22:46663545 TTC38 0.53 5.78 0.3 1.72e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs7208859 0.623 rs7220999 chr17:29149298 C/T cg13385521 chr17:29058706 SUZ12P 0.65 6.26 0.32 1.18e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7424096 0.613 rs72873859 chr2:37246738 T/G cg14987922 chr2:37194071 STRN 0.63 8.51 0.42 6.03e-16 High light scatter reticulocyte percentage of red cells; LUSC cis rs911119 0.955 rs6048952 chr20:23607257 A/G cg16589663 chr20:23618590 CST3 0.57 6.86 0.35 3.3e-11 Chronic kidney disease; LUSC cis rs4891159 0.548 rs2554830 chr18:74127702 A/G cg24786174 chr18:74118243 ZNF516 0.97 22.28 0.77 5.14e-68 Longevity; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.88 0.44 4.25e-17 Prudent dietary pattern; LUSC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.6 0.47 1.97e-19 Bipolar disorder; LUSC cis rs34779708 0.931 rs11010077 chr10:35328088 C/T cg04310649 chr10:35416472 CREM 0.37 5.73 0.3 2.22e-8 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg00071950 chr4:10020882 SLC2A9 0.64 10.93 0.51 5.65e-24 Bone mineral density; LUSC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg11752832 chr7:134001865 SLC35B4 0.53 8.17 0.41 6.6e-15 Mean platelet volume; LUSC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg05425664 chr17:57184151 TRIM37 0.59 9.13 0.45 6.81e-18 Intelligence (multi-trait analysis); LUSC cis rs1059312 1.000 rs7302634 chr12:129279931 C/T cg05253716 chr12:129299332 SLC15A4;MGC16384 0.46 6.6 0.34 1.63e-10 Systemic lupus erythematosus; LUSC cis rs611744 0.647 rs689275 chr8:109241822 T/C cg21045802 chr8:109455806 TTC35 0.42 6.46 0.33 3.68e-10 Dupuytren's disease; LUSC cis rs1160297 0.609 rs10167421 chr2:53096163 G/C cg07782112 chr2:53107842 NA 0.43 6.99 0.36 1.51e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg13770153 chr20:60521292 NA -0.63 -8.53 -0.42 5.08e-16 Body mass index; LUSC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg21573476 chr21:45109991 RRP1B -0.41 -6.66 -0.34 1.11e-10 Mean corpuscular volume; LUSC cis rs7193541 0.965 rs28616016 chr16:74676964 T/C cg01733217 chr16:74700730 RFWD3 0.87 15.57 0.65 1.79e-41 Multiple myeloma; LUSC cis rs701145 0.537 rs1713815 chr3:153872445 T/C cg17054900 chr3:154042577 DHX36 0.56 5.7 0.3 2.6e-8 Coronary artery disease; LUSC cis rs9948 0.655 rs2280356 chr2:97366324 C/T cg01990225 chr2:97406019 LMAN2L 1.03 7.95 0.4 2.9e-14 Erectile dysfunction and prostate cancer treatment; LUSC cis rs701145 0.556 rs355758 chr3:154007682 C/G cg10247383 chr3:153839028 SGEF 0.51 6.39 0.33 5.62e-10 Coronary artery disease; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg14893161 chr1:205819251 PM20D1 1.02 24.54 0.8 9.61e-77 Menarche (age at onset); LUSC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs1595825 0.891 rs73056840 chr2:198783466 C/A cg10547527 chr2:198650123 BOLL -0.49 -5.79 -0.3 1.65e-8 Ulcerative colitis; LUSC cis rs10875746 0.951 rs10875756 chr12:48562304 C/T cg13454099 chr12:49076203 C12orf41 -0.5 -5.92 -0.31 8.18e-9 Longevity (90 years and older); LUSC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg15147215 chr3:52552868 STAB1 -0.33 -6.45 -0.33 3.88e-10 Electroencephalogram traits; LUSC cis rs2769264 1.000 rs6684085 chr1:151357333 C/T cg18801370 chr1:151430492 POGZ -0.59 -7.63 -0.39 2.56e-13 Blood trace element (Cu levels); LUSC cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg13699009 chr12:122356056 WDR66 -0.47 -7.4 -0.38 1.08e-12 Mean corpuscular volume; LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg08677398 chr8:58056175 NA 0.45 6.41 0.33 5.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg17968037 chr7:100024898 ZCWPW1 -0.4 -5.98 -0.31 5.86e-9 Platelet count; LUSC trans rs2243480 1.000 rs73150014 chr7:65450919 A/C cg10756647 chr7:56101905 PSPH 0.86 8.39 0.42 1.36e-15 Diabetic kidney disease; LUSC trans rs1486139 0.935 rs9639951 chr7:46282898 T/C cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2e-10 Select biomarker traits; LUSC cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.91 17.8 0.7 2.62e-50 Body mass index (adult); LUSC trans rs7824557 0.564 rs2572399 chr8:11234520 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.74 -0.39 1.21e-13 Retinal vascular caliber; LUSC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg02380750 chr20:61661411 NA 0.33 5.73 0.3 2.23e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg05368731 chr17:41323189 NBR1 0.93 16.11 0.66 1.32e-43 Menopause (age at onset); LUSC cis rs835154 0.845 rs835155 chr5:14875868 A/G cg18064842 chr5:14874549 NA 0.36 5.78 0.3 1.75e-8 Blood metabolite levels; LUSC cis rs7917772 0.582 rs7075269 chr10:104365724 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.82 0.51 1.39e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13256369 0.950 rs1522839 chr8:8580453 C/T cg17143192 chr8:8559678 CLDN23 0.6 8.25 0.41 3.65e-15 Obesity-related traits; LUSC cis rs77633900 0.614 rs2439992 chr15:76863023 T/G cg21673338 chr15:77095150 SCAPER -0.73 -7.47 -0.38 6.86e-13 Non-glioblastoma glioma;Glioma; LUSC cis rs12210905 1.000 rs7756481 chr6:27115069 G/C cg11502198 chr6:26597334 ABT1 -0.78 -5.65 -0.3 3.46e-8 Hip circumference adjusted for BMI; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg11843238 chr5:131593191 PDLIM4 0.38 7.0 0.36 1.45e-11 Blood metabolite levels; LUSC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg10523679 chr1:76189770 ACADM 0.89 13.88 0.6 6.48e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17270561 0.609 rs12529272 chr6:25731342 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.6 0.38 3.1e-13 Iron status biomarkers; LUSC cis rs55728055 0.661 rs62237775 chr22:31965401 A/G cg01338084 chr22:32026380 PISD 0.93 6.77 0.35 5.67e-11 Age-related hearing impairment; LUSC cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs7789940 1.000 rs73140069 chr7:75986790 T/A cg15798862 chr7:76129360 DTX2 -0.51 -8.54 -0.42 4.77e-16 Multiple sclerosis; LUSC cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg24296786 chr1:45957014 TESK2 -0.52 -8.1 -0.41 1.06e-14 High light scatter reticulocyte count; LUSC trans rs7618501 0.633 rs6446193 chr3:50059758 T/C cg21659725 chr3:3221576 CRBN -0.62 -10.33 -0.49 7e-22 Intelligence (multi-trait analysis); LUSC cis rs870825 0.581 rs7675106 chr4:185652388 C/G cg04058563 chr4:185651563 MLF1IP -0.79 -11.92 -0.55 1.5e-27 Blood protein levels; LUSC cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg23788917 chr6:8435910 SLC35B3 -0.52 -7.67 -0.39 1.94e-13 Motion sickness; LUSC cis rs7296418 0.630 rs11057238 chr12:123767971 C/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.75 -0.35 6.49e-11 Platelet count; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg25703541 chr22:24373054 LOC391322 -0.89 -14.74 -0.63 3.15e-38 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs644799 0.710 rs11021311 chr11:95505227 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.12 0.58 5.41e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.06 14.38 0.62 7.96e-37 Gut microbiome composition (summer); LUSC cis rs2486288 0.656 rs6493143 chr15:45570781 G/T cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.84 -0.51 1.2e-23 Glomerular filtration rate; LUSC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg08847533 chr14:75593920 NEK9 0.81 14.66 0.63 6.35e-38 Height; LUSC cis rs6121246 0.542 rs6059761 chr20:30110522 G/C cg18721089 chr20:30220636 NA -0.44 -7.03 -0.36 1.15e-11 Mean corpuscular hemoglobin; LUSC cis rs1178968 0.901 rs9784947 chr7:72748888 C/G cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.84e-13 Triglyceride levels; LUSC cis rs13082711 0.595 rs1445114 chr3:27345489 C/A cg02860705 chr3:27208620 NA 0.73 11.6 0.54 2.24e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Melanoma; LUSC cis rs1371867 0.846 rs1788196 chr8:101290088 C/T cg00191853 chr8:101177733 SPAG1 -0.39 -6.49 -0.33 3.19e-10 Atrioventricular conduction; LUSC cis rs614226 0.938 rs7963543 chr12:120923948 C/A cg27489772 chr12:121021490 NA 0.56 7.5 0.38 5.82e-13 Type 1 diabetes nephropathy; LUSC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg03517284 chr6:25882590 NA 0.39 6.63 0.34 1.37e-10 Intelligence (multi-trait analysis); LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg04576048 chr1:205797593 PM20D1 0.35 6.14 0.32 2.31e-9 Menarche (age at onset); LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg27094323 chr7:1216898 NA -0.49 -8.23 -0.41 4.36e-15 Longevity;Endometriosis; LUSC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.78 0.3 1.71e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2153535 0.869 rs11962457 chr6:8375855 A/T cg21535247 chr6:8435926 SLC35B3 -0.45 -6.48 -0.33 3.28e-10 Motion sickness; LUSC cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg22782873 chr19:19639568 YJEFN3 -0.48 -5.93 -0.31 7.37e-9 Bipolar disorder; LUSC cis rs79839061 0.610 rs11726280 chr4:864077 C/T cg23992470 chr4:843637 GAK 0.6 6.43 0.33 4.53e-10 Intelligence (multi-trait analysis); LUSC cis rs2898290 0.540 rs35005793 chr8:11450472 G/A cg21775007 chr8:11205619 TDH 0.41 5.74 0.3 2.08e-8 Systolic blood pressure; LUSC cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg13010199 chr12:38710504 ALG10B 0.65 10.13 0.48 3.32e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs17270561 0.583 rs6937800 chr6:25765943 A/G cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs6964587 0.869 rs6979024 chr7:91481512 T/C cg22709100 chr7:91322751 NA -0.4 -5.92 -0.31 7.94e-9 Breast cancer; LUSC cis rs2625529 0.526 rs16956623 chr15:72536695 T/C cg16672083 chr15:72433130 SENP8 0.47 7.84 0.39 5.96e-14 Red blood cell count; LUSC trans rs2736337 0.532 rs6998387 chr8:11293458 C/T cg15556689 chr8:8085844 FLJ10661 0.45 6.24 0.32 1.33e-9 Rheumatoid arthritis; LUSC cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC cis rs10887741 0.646 rs11202502 chr10:89437933 C/T cg13926569 chr10:89418898 PAPSS2 0.28 6.03 0.31 4.44e-9 Exercise (leisure time); LUSC cis rs6942756 0.806 rs2566877 chr7:128897317 G/A cg02491457 chr7:128862824 NA 0.51 7.59 0.38 3.18e-13 White matter hyperintensity burden; LUSC cis rs5770917 1.000 rs12627787 chr22:51012381 C/T cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.59 -5.69 -0.3 2.84e-8 Narcolepsy; LUSC cis rs7824557 0.545 rs2736303 chr8:11236850 C/T cg21775007 chr8:11205619 TDH -0.65 -10.26 -0.49 1.22e-21 Retinal vascular caliber; LUSC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC cis rs2078087 0.522 rs3768593 chr1:183212548 G/T cg13843938 chr1:183241246 NMNAT2 -0.4 -6.35 -0.33 6.91e-10 Obesity-related traits; LUSC cis rs72634258 0.554 rs35307738 chr1:7919839 C/G cg26816564 chr1:7831052 VAMP3 0.71 9.66 0.47 1.23e-19 Inflammatory bowel disease; LUSC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg00101154 chr16:420108 MRPL28 -0.61 -10.47 -0.5 2.29e-22 Bone mineral density (spine);Bone mineral density; LUSC cis rs72772090 0.634 rs72773906 chr5:96092274 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.74 -8.36 -0.42 1.74e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs7746199 0.736 rs72845070 chr6:27668300 A/C cg01620082 chr3:125678407 NA -0.76 -6.58 -0.34 1.86e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1003719 1.000 rs2835607 chr21:38491973 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.66 10.3 0.49 8.73e-22 Eye color traits; LUSC trans rs35110281 0.506 rs13051661 chr21:45111518 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 9.93 0.48 1.61e-20 Mean corpuscular volume; LUSC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg06740227 chr12:86229804 RASSF9 0.43 6.61 0.34 1.48e-10 Major depressive disorder; LUSC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg18477163 chr1:228402036 OBSCN 0.63 12.33 0.56 4.77e-29 Diastolic blood pressure; LUSC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg23719950 chr11:63933701 MACROD1 -0.39 -6.12 -0.32 2.58e-9 Platelet count; LUSC trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg03929089 chr4:120376271 NA 0.51 6.17 0.32 1.98e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs731174 0.797 rs510208 chr1:38147166 A/G cg14170840 chr1:38155120 C1orf109 -0.38 -6.12 -0.32 2.64e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2486288 0.656 rs2413772 chr15:45549862 G/A cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.78 -0.51 1.91e-23 Glomerular filtration rate; LUSC cis rs9463078 0.764 rs10948194 chr6:44951990 A/C cg25276700 chr6:44698697 NA -0.29 -5.85 -0.3 1.16e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9329221 0.527 rs34308302 chr8:10332022 C/T cg27411982 chr8:10470053 RP1L1 -0.46 -6.89 -0.35 2.72e-11 Neuroticism; LUSC cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg13010199 chr12:38710504 ALG10B 0.69 11.46 0.53 7.01e-26 Heart rate; LUSC cis rs5758511 0.573 rs2267439 chr22:42237769 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.4 -7.53 -0.38 4.88e-13 Birth weight; LUSC cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg18404041 chr3:52824283 ITIH1 -0.58 -9.84 -0.47 3.09e-20 Schizophrenia; LUSC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg14552801 chr7:65878734 NA -0.43 -6.19 -0.32 1.73e-9 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17738503 chr17:49244158 NME2;NME1-NME2 -0.51 -6.64 -0.34 1.29e-10 Bipolar disorder and schizophrenia; LUSC cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs709400 0.663 rs62007687 chr14:103903763 G/T cg24130564 chr14:104152367 KLC1 -0.45 -6.29 -0.33 9.95e-10 Body mass index; LUSC cis rs8060686 0.563 rs118005841 chr16:68157562 A/T cg27539214 chr16:67997921 SLC12A4 -0.58 -7.26 -0.37 2.78e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10740039 0.810 rs10821800 chr10:62367570 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.87 -0.35 3.12e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg27661571 chr11:113659931 NA -0.67 -7.72 -0.39 1.4e-13 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.73 -0.35 7.4e-11 Lung cancer; LUSC cis rs11971779 0.618 rs13068 chr7:139104141 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs13082711 0.911 rs13082777 chr3:27421942 A/G cg02860705 chr3:27208620 NA 0.49 8.36 0.42 1.76e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg27170947 chr2:26402098 FAM59B 0.72 10.79 0.51 1.8e-23 Gut microbiome composition (summer); LUSC cis rs3737883 1.000 rs2275354 chr1:203036757 T/C cg00805880 chr1:203045044 PPFIA4 -0.28 -5.7 -0.3 2.7e-8 Early onset atrial fibrillation; LUSC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg04546413 chr19:29218101 NA 0.56 7.75 0.39 1.08e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7223966 1.000 rs8073373 chr17:61703320 T/C cg05941027 chr17:61774174 LIMD2 0.23 6.13 0.32 2.52e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg21724239 chr8:58056113 NA 0.56 6.9 0.35 2.7e-11 Developmental language disorder (linguistic errors); LUSC cis rs4631830 0.863 rs3101227 chr10:51520203 C/A cg20129853 chr10:51489980 NA -0.32 -6.4 -0.33 5.23e-10 Prostate-specific antigen levels; LUSC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg20744362 chr22:50050164 C22orf34 0.4 8.23 0.41 4.3e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9527 0.590 rs2148200 chr10:104879847 C/A cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11644478 chr21:40555479 PSMG1 -0.77 -13.54 -0.6 1.3e-33 Cognitive function; LUSC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg06634786 chr22:41940651 POLR3H 0.51 5.87 0.31 1.04e-8 Vitiligo; LUSC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg08677398 chr8:58056175 NA -0.5 -6.24 -0.32 1.33e-9 Developmental language disorder (linguistic errors); LUSC cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg19875535 chr5:140030758 IK -0.55 -9.1 -0.45 8.22e-18 Depressive symptoms (multi-trait analysis); LUSC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg18904891 chr8:8559673 CLDN23 -0.61 -8.65 -0.43 2.23e-16 Obesity-related traits; LUSC trans rs7819412 0.691 rs73198970 chr8:11040216 T/C cg06636001 chr8:8085503 FLJ10661 -0.48 -6.83 -0.35 3.92e-11 Triglycerides; LUSC trans rs9329221 0.537 rs6983332 chr8:9977918 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.69 -0.34 9.66e-11 Neuroticism; LUSC cis rs10740039 0.846 rs2165690 chr10:62399367 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg24562669 chr7:97807699 LMTK2 -0.39 -6.32 -0.33 8.25e-10 Breast cancer; LUSC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg24110177 chr3:50126178 RBM5 -0.57 -9.59 -0.46 2.2e-19 Intelligence (multi-trait analysis); LUSC cis rs7193541 1.000 rs7193541 chr16:74664743 C/T cg01733217 chr16:74700730 RFWD3 -0.83 -14.89 -0.63 8.15e-39 Multiple myeloma; LUSC cis rs11098499 0.754 rs12506487 chr4:120271361 T/G cg24375607 chr4:120327624 NA 0.66 10.52 0.5 1.48e-22 Corneal astigmatism; LUSC cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg21475434 chr5:93447410 FAM172A 0.62 8.54 0.42 4.8e-16 Diabetic retinopathy; LUSC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg26977086 chr12:132329805 MMP17 -0.27 -6.13 -0.32 2.45e-9 Migraine; LUSC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg07636037 chr3:49044803 WDR6 -0.87 -14.47 -0.62 3.38e-37 Menarche (age at onset); LUSC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg00049323 chr5:472564 LOC25845 -0.44 -6.86 -0.35 3.27e-11 Cystic fibrosis severity; LUSC cis rs34779708 0.966 rs35814343 chr10:35427714 G/T cg04310649 chr10:35416472 CREM -0.43 -6.64 -0.34 1.29e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4974559 0.739 rs1250121 chr4:1263521 A/G cg02980000 chr4:1222292 CTBP1 -0.99 -9.46 -0.46 5.57e-19 Systolic blood pressure; LUSC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC trans rs13011075 0.919 rs2241946 chr2:68615654 T/C cg14221825 chr19:46271408 SIX5 0.44 6.32 0.33 8.52e-10 Mean corpuscular volume; LUSC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg02269571 chr22:50332266 NA -0.55 -8.2 -0.41 5.16e-15 Schizophrenia; LUSC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg11584989 chr19:19387371 SF4 0.52 6.29 0.33 9.89e-10 Bipolar disorder; LUSC cis rs62400317 0.731 rs12214435 chr6:44906717 G/A cg20913747 chr6:44695427 NA -0.48 -7.4 -0.38 1.08e-12 Total body bone mineral density; LUSC cis rs62400317 0.859 rs12193720 chr6:45103362 A/G cg18551225 chr6:44695536 NA -0.42 -6.95 -0.36 1.93e-11 Total body bone mineral density; LUSC cis rs6087990 0.806 rs4911254 chr20:31357579 C/A cg13636640 chr20:31349939 DNMT3B 1.01 23.33 0.79 4.32e-72 Ulcerative colitis; LUSC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg11366901 chr6:160182831 ACAT2 -0.82 -11.55 -0.53 3.56e-26 Age-related macular degeneration (geographic atrophy); LUSC cis rs250677 0.687 rs40149 chr5:148444275 A/T cg23229984 chr5:148520753 ABLIM3 0.4 6.41 0.33 4.85e-10 Breast cancer; LUSC cis rs7212590 0.655 rs8070039 chr17:57973585 G/C cg10252138 chr17:58120427 NA -0.78 -7.19 -0.37 4.2e-12 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs7267979 1.000 rs2258617 chr20:25274318 C/T cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg11861562 chr11:117069780 TAGLN 0.34 6.59 0.34 1.75e-10 Blood protein levels; LUSC cis rs7100689 0.784 rs6585986 chr10:82171559 T/C cg00277334 chr10:82204260 NA -0.52 -7.08 -0.36 8.7e-12 Post bronchodilator FEV1; LUSC cis rs4073416 0.518 rs7157109 chr14:65900433 C/G cg03016385 chr14:66212404 NA -0.39 -5.85 -0.3 1.19e-8 N-glycan levels; LUSC cis rs2758596 0.850 rs2495270 chr1:156181530 A/G cg25208724 chr1:156163844 SLC25A44 0.82 6.53 0.34 2.48e-10 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.73 -0.3 2.25e-8 Depression; LUSC cis rs7582180 0.607 rs6725052 chr2:100935817 G/A cg12002119 chr2:101014098 CHST10 0.34 5.7 0.3 2.62e-8 Intelligence (multi-trait analysis); LUSC cis rs9486719 0.656 rs6924957 chr6:96853579 G/T cg06623918 chr6:96969491 KIAA0776 0.73 10.34 0.49 6.35e-22 Migraine;Coronary artery disease; LUSC cis rs8044995 0.636 rs117761434 chr16:68254196 G/A cg05110241 chr16:68378359 PRMT7 -0.64 -6.99 -0.36 1.46e-11 Schizophrenia; LUSC trans rs6952808 0.564 rs73038441 chr7:2139286 T/C cg04565464 chr8:145669602 NFKBIL2 0.37 5.99 0.31 5.49e-9 Bipolar disorder and schizophrenia; LUSC cis rs28595532 0.702 rs72670238 chr4:119322751 C/T cg21605333 chr4:119757512 SEC24D 1.03 8.59 0.43 3.38e-16 Cannabis dependence symptom count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10896623 chr1:19923370 C1orf151 0.46 6.08 0.32 3.28e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2637266 0.783 rs58247832 chr10:78471383 C/A cg18941641 chr10:78392320 NA 0.35 6.25 0.32 1.25e-9 Pulmonary function; LUSC cis rs921665 0.831 rs11688404 chr2:3188755 C/T cg16434511 chr2:3151078 NA -0.6 -6.8 -0.35 4.76e-11 World class endurance athleticism; LUSC trans rs877282 0.947 rs7475589 chr10:767479 C/G cg22713356 chr15:30763199 NA 1.1 15.67 0.65 7.18e-42 Uric acid levels; LUSC cis rs10791323 0.575 rs4489760 chr11:133732265 A/T cg00579200 chr11:133705235 NA -0.38 -5.93 -0.31 7.58e-9 Childhood ear infection; LUSC cis rs751728 1.000 rs1359781 chr6:33762104 T/C cg25922239 chr6:33757077 LEMD2 0.55 8.27 0.41 3.25e-15 Crohn's disease; LUSC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg15468180 chr1:107600409 PRMT6 -0.39 -6.14 -0.32 2.37e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9527 0.568 rs12772775 chr10:104702999 C/A cg04362960 chr10:104952993 NT5C2 0.59 9.35 0.46 1.34e-18 Arsenic metabolism; LUSC cis rs1953600 0.540 rs2784773 chr10:81919800 A/G cg00277334 chr10:82204260 NA -0.47 -6.95 -0.36 1.98e-11 Sarcoidosis; LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg24675658 chr1:53192096 ZYG11B 0.59 9.22 0.45 3.51e-18 Monocyte count; LUSC trans rs7786808 0.705 rs1377373 chr7:158215549 A/C cg02030672 chr11:45687055 CHST1 -0.44 -6.75 -0.35 6.38e-11 Obesity-related traits; LUSC cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.5 6.84 0.35 3.84e-11 Cognitive ability; LUSC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg04414720 chr1:150670196 GOLPH3L 0.53 8.47 0.42 7.75e-16 Tonsillectomy; LUSC cis rs11630290 0.589 rs1396710 chr15:64168461 C/G cg12036633 chr15:63758958 NA 0.48 5.98 0.31 5.6e-9 Iris characteristics; LUSC cis rs11997175 0.646 rs55898196 chr8:33765862 A/G ch.8.33884649F chr8:33765107 NA 0.53 8.29 0.41 2.89e-15 Body mass index; LUSC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg26335602 chr6:28129616 ZNF389 0.43 5.74 0.3 2.17e-8 Depression; LUSC cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC cis rs1865760 0.865 rs1436306 chr6:25948421 A/G cg16482183 chr6:26056742 HIST1H1C 0.47 6.93 0.35 2.12e-11 Height; LUSC cis rs4285028 0.847 rs1986712 chr3:121710986 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.69 -8.83 -0.43 6.15e-17 Multiple sclerosis; LUSC trans rs2055729 0.645 rs12056944 chr8:9742525 C/G cg15556689 chr8:8085844 FLJ10661 0.49 6.07 0.32 3.42e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs7178375 1.000 rs7178533 chr15:31215976 C/G cg04373760 chr16:53404718 NA 0.65 8.9 0.44 3.67e-17 Hypertriglyceridemia; LUSC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg22532475 chr10:104410764 TRIM8 0.3 5.97 0.31 6.17e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.89 0.31 9.6e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.12 0.48 3.52e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9868809 0.881 rs13324142 chr3:48669447 C/T cg00383909 chr3:49044727 WDR6 1.01 9.87 0.48 2.43e-20 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25852545 chr3:113775465 KIAA1407;QTRTD1 -0.43 -6.59 -0.34 1.68e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg07636037 chr3:49044803 WDR6 1.04 18.79 0.72 2.9e-54 Parkinson's disease; LUSC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.16 -0.32 2.06e-9 Total body bone mineral density; LUSC cis rs2439831 0.867 rs2920781 chr15:43924682 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg12163867 chr12:51592794 POU6F1 -0.61 -10.84 -0.51 1.17e-23 Cisplatin-induced ototoxicity; LUSC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg18190219 chr22:46762943 CELSR1 -0.48 -6.0 -0.31 5.03e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6121246 0.529 rs56153385 chr20:30187609 C/T cg18721089 chr20:30220636 NA -0.41 -6.57 -0.34 1.93e-10 Mean corpuscular hemoglobin; LUSC cis rs59698941 0.943 rs66732439 chr5:132234702 A/G cg02081065 chr5:132209139 LEAP2 -0.65 -6.85 -0.35 3.55e-11 Apolipoprotein A-IV levels; LUSC trans rs4714291 0.802 rs3008833 chr6:39986303 G/A cg02267698 chr19:7991119 CTXN1 -0.53 -7.85 -0.39 5.68e-14 Strep throat; LUSC cis rs1595825 0.891 rs114426561 chr2:198698891 A/G cg10547527 chr2:198650123 BOLL -0.51 -5.94 -0.31 7.2e-9 Ulcerative colitis; LUSC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg11189052 chr15:85197271 WDR73 -0.66 -10.13 -0.48 3.38e-21 P wave terminal force; LUSC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg20573242 chr4:122745356 CCNA2 0.43 6.5 0.33 3e-10 Type 2 diabetes; LUSC cis rs113835537 0.529 rs11227510 chr11:66281220 T/C cg24851651 chr11:66362959 CCS 0.53 7.93 0.4 3.42e-14 Airway imaging phenotypes; LUSC cis rs9300255 0.544 rs1790100 chr12:123656725 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -6.39 -0.33 5.69e-10 Neutrophil percentage of white cells; LUSC trans rs7618501 0.665 rs7621352 chr3:50070763 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.44 -0.46 6.86e-19 Intelligence (multi-trait analysis); LUSC trans rs208520 0.754 rs12204635 chr6:66740779 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.82 0.68 2.11e-46 Exhaled nitric oxide output; LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg14092988 chr3:52407081 DNAH1 0.32 6.01 0.31 4.95e-9 Bipolar disorder; LUSC cis rs6087990 0.899 rs1883729 chr20:31363193 G/A cg13636640 chr20:31349939 DNMT3B 1.0 22.63 0.78 2.14e-69 Ulcerative colitis; LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 12.08 0.55 3.96e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg07677032 chr17:61819896 STRADA 0.52 8.61 0.43 2.91e-16 Prudent dietary pattern; LUSC trans rs11764590 0.715 rs62444907 chr7:2083267 C/T cg10840412 chr1:235813424 GNG4 0.53 6.26 0.32 1.15e-9 Neuroticism; LUSC cis rs7605827 0.930 rs2010881 chr2:15624646 T/A cg19274914 chr2:15703543 NA 0.46 8.82 0.43 6.51e-17 Educational attainment (years of education); LUSC cis rs7589342 0.801 rs2889605 chr2:106525073 T/C cg16077055 chr2:106428750 NCK2 0.35 6.53 0.34 2.48e-10 Addiction; LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg02951883 chr7:2050386 MAD1L1 -0.39 -6.75 -0.35 6.69e-11 Bipolar disorder and schizophrenia; LUSC cis rs4780401 0.609 rs55934118 chr16:11820003 G/C cg01061890 chr16:11836724 TXNDC11 -0.56 -8.58 -0.42 3.69e-16 Rheumatoid arthritis; LUSC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg03709012 chr19:19516395 GATAD2A -0.76 -11.86 -0.54 2.68e-27 Tonsillectomy; LUSC cis rs2882667 0.898 rs4380651 chr5:138391072 A/G cg04439458 chr5:138467593 SIL1 -0.41 -8.25 -0.41 3.8e-15 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs17655565 0.533 rs12301094 chr12:52707610 A/G cg08257133 chr12:52711352 KRT83 0.42 9.06 0.44 1.09e-17 Plasma amyloid beta peptide concentrations (ABx-42); LUSC cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.3 -5.78 -0.3 1.75e-8 Schizophrenia; LUSC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06258179 chr7:92463261 CDK6 -0.42 -6.58 -0.34 1.79e-10 Electrocardiographic conduction measures; LUSC trans rs4665809 0.941 rs3177055 chr2:26359315 G/A cg19249749 chr1:223853145 CAPN8 -0.47 -5.95 -0.31 6.59e-9 Gut microbiome composition (summer); LUSC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg17554472 chr22:41940697 POLR3H -0.48 -5.77 -0.3 1.83e-8 Vitiligo; LUSC cis rs9976767 0.608 rs9784208 chr21:43824986 A/G cg20516845 chr21:43823604 UBASH3A -0.25 -5.86 -0.31 1.08e-8 Type 1 diabetes; LUSC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg02951883 chr7:2050386 MAD1L1 -0.47 -8.11 -0.41 9.71e-15 Schizophrenia; LUSC trans rs3749237 1.000 rs6804655 chr3:49738945 C/T cg21659725 chr3:3221576 CRBN 0.64 9.19 0.45 4.33e-18 Resting heart rate; LUSC cis rs7567389 0.740 rs4536600 chr2:128002572 A/G cg09760422 chr2:128146352 NA 0.32 6.8 0.35 4.87e-11 Self-rated health; LUSC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.05 0.4 1.43e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg08999081 chr20:33150536 PIGU -0.42 -7.69 -0.39 1.66e-13 Coronary artery disease; LUSC cis rs6087990 0.899 rs6058893 chr20:31392777 C/T cg13636640 chr20:31349939 DNMT3B 0.94 20.49 0.75 5.54e-61 Ulcerative colitis; LUSC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg18904891 chr8:8559673 CLDN23 0.58 8.07 0.4 1.25e-14 Obesity-related traits; LUSC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg07395648 chr5:131743802 NA -0.42 -6.64 -0.34 1.28e-10 Breast cancer;Mosquito bite size; LUSC cis rs7937682 0.663 rs35581942 chr11:111756286 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.47 0.56 1.46e-29 Primary sclerosing cholangitis; LUSC cis rs77741769 0.571 rs3883901 chr12:121256520 A/G cg02419362 chr12:121203948 SPPL3 0.45 8.48 0.42 7.61e-16 Mean corpuscular volume; LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg02980000 chr4:1222292 CTBP1 -0.4 -5.93 -0.31 7.67e-9 Obesity-related traits; LUSC cis rs7584330 0.554 rs74001384 chr2:238424530 T/C cg16989719 chr2:238392110 NA -0.4 -5.84 -0.3 1.27e-8 Prostate cancer; LUSC cis rs7267979 1.000 rs8125868 chr20:25324410 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.6 -0.34 1.66e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg08677398 chr8:58056175 NA 0.52 6.01 0.31 4.78e-9 Developmental language disorder (linguistic errors); LUSC cis rs6554196 0.525 rs12499367 chr4:55505911 C/T cg18836493 chr4:55524333 KIT -0.43 -7.38 -0.37 1.29e-12 Monocyte count; LUSC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg18964960 chr10:1102726 WDR37 -0.51 -7.67 -0.39 1.93e-13 Response to angiotensin II receptor blocker therapy; LUSC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg20891283 chr12:69753455 YEATS4 0.62 9.59 0.46 2.18e-19 Response to diuretic therapy; LUSC cis rs7553864 0.614 rs1886634 chr1:87614821 C/T cg17420885 chr1:87600446 LOC339524 0.49 6.79 0.35 4.99e-11 Smoking behavior; LUSC cis rs12200560 0.505 rs211178 chr6:97074094 T/A cg06623918 chr6:96969491 KIAA0776 0.51 7.33 0.37 1.78e-12 Coronary heart disease; LUSC cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg00321850 chr1:175162397 KIAA0040 -0.45 -7.79 -0.39 8.64e-14 Alcohol dependence; LUSC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg07061783 chr6:25882402 NA 0.43 6.07 0.32 3.5e-9 Blood metabolite levels; LUSC cis rs7954584 0.504 rs10840633 chr12:122377511 A/T cg21016266 chr12:122356598 WDR66 0.62 9.1 0.45 8.44e-18 Mean corpuscular volume; LUSC cis rs8058578 1.000 rs67456513 chr16:30714828 A/T cg02466173 chr16:30829666 NA -0.59 -10.83 -0.51 1.28e-23 Multiple myeloma; LUSC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.32 0.56 5.27e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7180079 1.000 rs12903745 chr15:64632840 G/A cg08069370 chr15:64387884 SNX1 0.55 5.99 0.31 5.37e-9 Monocyte count; LUSC cis rs17688076 0.511 rs2418738 chr16:68122604 G/C cg05110241 chr16:68378359 PRMT7 -0.51 -6.15 -0.32 2.25e-9 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg27094323 chr7:1216898 NA -0.46 -8.14 -0.41 8.08e-15 Longevity;Endometriosis; LUSC cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg11244672 chr19:19639970 YJEFN3 0.6 7.33 0.37 1.72e-12 Bipolar disorder; LUSC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg02782426 chr3:40428986 ENTPD3 0.41 7.61 0.38 2.87e-13 Renal cell carcinoma; LUSC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg01448562 chr3:133502909 NA -0.66 -10.75 -0.51 2.4e-23 Iron status biomarkers; LUSC cis rs55665837 1.000 rs11023214 chr11:14436259 G/C cg05501817 chr11:14380813 RRAS2 -0.41 -6.73 -0.35 7.47e-11 Vitamin D levels; LUSC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC cis rs62064224 0.791 rs11653160 chr17:30717222 A/G cg18200150 chr17:30822561 MYO1D 0.51 10.29 0.49 9.48e-22 Schizophrenia; LUSC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg22920501 chr2:26401640 FAM59B -0.73 -10.34 -0.49 6.17e-22 Gut microbiome composition (summer); LUSC cis rs79976124 0.837 rs75346757 chr6:66648386 A/T cg07460842 chr6:66804631 NA 0.73 9.11 0.45 7.89e-18 Type 2 diabetes; LUSC cis rs7903847 0.642 rs61863816 chr10:99128503 G/A cg20016023 chr10:99160130 RRP12 -0.31 -6.49 -0.33 3.05e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs7819412 0.806 rs6980856 chr8:10938260 A/G cg21775007 chr8:11205619 TDH 0.54 7.91 0.4 3.77e-14 Triglycerides; LUSC trans rs587847 0.507 rs1379349 chr15:37809122 T/C cg18296784 chr11:116147929 NA -0.35 -6.31 -0.33 9.08e-10 Intraocular pressure; LUSC cis rs6906287 0.537 rs13192336 chr6:118875162 A/T cg21191810 chr6:118973309 C6orf204 0.33 6.04 0.31 4.16e-9 Electrocardiographic conduction measures; LUSC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.28 0.33 1.03e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6121246 0.567 rs6058189 chr20:30192389 A/G cg13852791 chr20:30311386 BCL2L1 0.72 8.29 0.41 2.73e-15 Mean corpuscular hemoglobin; LUSC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg21918786 chr6:109611834 NA -0.36 -6.06 -0.31 3.76e-9 Reticulocyte fraction of red cells; LUSC cis rs2281845 0.507 rs942703 chr1:201092979 A/G cg22815214 chr1:201083145 CACNA1S -0.47 -6.68 -0.34 9.74e-11 Permanent tooth development; LUSC cis rs9467773 0.584 rs1021372 chr6:26632444 T/C cg09904177 chr6:26538194 HMGN4 0.65 11.7 0.54 9.83e-27 Intelligence (multi-trait analysis); LUSC cis rs427941 0.609 rs4729776 chr7:101830064 A/G cg06246474 chr7:101738831 CUX1 0.35 5.74 0.3 2.18e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4662945 0.525 rs28819474 chr2:130264623 T/C cg05962382 chr2:130345044 NA -0.35 -6.14 -0.32 2.28e-9 Response to cytidine analogues (gemcitabine); LUSC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg09555818 chr19:45449301 APOC2 0.44 8.18 0.41 5.99e-15 Blood protein levels; LUSC cis rs9398803 0.865 rs9372840 chr6:126822635 A/C cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 2.02e-9 Male-pattern baldness; LUSC trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg12311346 chr5:56204834 C5orf35 -0.64 -9.41 -0.46 8.57e-19 Coronary artery disease; LUSC cis rs7168353 0.519 rs725458 chr15:93634933 A/G cg02918577 chr15:93633145 RGMA -0.32 -5.98 -0.31 5.89e-9 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs1044826 0.642 rs2118981 chr3:139178853 A/G cg15131784 chr3:139108705 COPB2 0.41 6.71 0.34 8.17e-11 Obesity-related traits; LUSC cis rs12760731 0.565 rs12406779 chr1:178088936 C/G cg00404053 chr1:178313656 RASAL2 0.67 6.7 0.34 8.81e-11 Obesity-related traits; LUSC cis rs9487051 0.768 rs458740 chr6:109525527 C/T cg00509249 chr6:109615579 CCDC162 -0.33 -5.73 -0.3 2.23e-8 Reticulocyte fraction of red cells; LUSC cis rs2625529 0.668 rs8192431 chr15:72492352 G/A cg16672083 chr15:72433130 SENP8 -0.5 -7.36 -0.37 1.48e-12 Red blood cell count; LUSC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg17971929 chr21:40555470 PSMG1 -0.68 -11.14 -0.52 1.03e-24 Cognitive function; LUSC cis rs4702 0.611 rs1894401 chr15:91429042 C/T cg05469396 chr15:91419421 FURIN 0.46 8.21 0.41 4.95e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7937682 0.883 rs1613778 chr11:111456105 G/C cg09085632 chr11:111637200 PPP2R1B -1.01 -15.59 -0.65 1.42e-41 Primary sclerosing cholangitis; LUSC trans rs17685 0.849 rs3815455 chr7:75611756 C/T cg19862616 chr7:65841803 NCRNA00174 0.81 11.8 0.54 4.16e-27 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.53e-8 Menopause (age at onset); LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg26338869 chr17:61819248 STRADA 0.41 5.9 0.31 8.95e-9 Prudent dietary pattern; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 6.0 0.31 5.01e-9 Renal function-related traits (BUN); LUSC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg11764359 chr7:65958608 NA 0.71 10.7 0.51 3.64e-23 Aortic root size; LUSC cis rs752092 1.000 rs8033360 chr15:101778710 C/A cg19997662 chr15:101784653 CHSY1 -0.44 -6.4 -0.33 5.18e-10 Corneal structure; LUSC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg09323728 chr8:95962352 TP53INP1 -0.38 -7.61 -0.38 2.79e-13 Type 2 diabetes; LUSC cis rs11676348 0.808 rs4674261 chr2:219005009 G/C cg00012203 chr2:219082015 ARPC2 -0.54 -8.23 -0.41 4.33e-15 Ulcerative colitis; LUSC cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg21132104 chr15:45694354 SPATA5L1 -0.46 -6.07 -0.32 3.46e-9 Homoarginine levels; LUSC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg08045932 chr20:61659980 NA 0.59 10.36 0.49 5.39e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg06873352 chr17:61820015 STRADA 0.72 12.45 0.56 1.78e-29 Prudent dietary pattern; LUSC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.7 0.34 9.07e-11 Intelligence (multi-trait analysis); LUSC cis rs748404 0.697 rs493177 chr15:43543258 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.45 6.79 0.35 5.03e-11 Lung cancer; LUSC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.22 -0.45 3.54e-18 Prostate cancer; LUSC cis rs3540 0.597 rs12708583 chr15:91050271 C/T cg22089800 chr15:90895588 ZNF774 0.66 10.8 0.51 1.59e-23 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg18350739 chr11:68623251 NA -0.37 -6.39 -0.33 5.69e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6142102 0.961 rs2300204 chr20:32588773 G/A cg08999081 chr20:33150536 PIGU 0.35 5.92 0.31 8.15e-9 Skin pigmentation; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg15088822 chr5:140998632 DIAPH1 0.4 6.26 0.32 1.2e-9 Mosquito bite size; LUSC cis rs11098499 0.754 rs17049949 chr4:120255290 A/G cg24375607 chr4:120327624 NA 0.77 12.56 0.57 6.5e-30 Corneal astigmatism; LUSC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg13206674 chr6:150067644 NUP43 0.6 9.26 0.45 2.6e-18 Lung cancer; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.65 0.76 1.42e-65 Prudent dietary pattern; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg24060327 chr5:131705240 SLC22A5 -0.39 -6.45 -0.33 3.89e-10 Blood metabolite levels; LUSC cis rs7216064 1.000 rs35243555 chr17:65876477 G/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs977987 0.843 rs60730309 chr16:75431769 C/G cg03315344 chr16:75512273 CHST6 0.54 10.38 0.49 4.69e-22 Dupuytren's disease; LUSC cis rs4629180 1.000 rs6744495 chr2:102099956 T/C cg04415270 chr2:102091202 RFX8 -0.55 -8.67 -0.43 1.84e-16 Chronic rhinosinusitis with nasal polyps; LUSC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg09359103 chr1:154839909 KCNN3 0.55 10.83 0.51 1.28e-23 Prostate cancer; LUSC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg20476274 chr7:133979776 SLC35B4 0.87 16.95 0.68 5.94e-47 Mean platelet volume; LUSC cis rs72960926 0.744 rs6941436 chr6:74937191 C/T cg03266952 chr6:74778945 NA 0.76 6.31 0.33 8.87e-10 Metabolite levels (MHPG); LUSC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg13770153 chr20:60521292 NA -0.64 -8.62 -0.43 2.74e-16 Body mass index; LUSC trans rs1908814 0.516 rs58869268 chr8:11797095 G/C cg06636001 chr8:8085503 FLJ10661 0.55 8.04 0.4 1.6e-14 Neuroticism; LUSC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg16049864 chr8:95962084 TP53INP1 -0.64 -12.01 -0.55 7.15e-28 Type 2 diabetes; LUSC cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg06028605 chr16:24865363 SLC5A11 0.49 8.49 0.42 6.67e-16 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.45 -0.5 2.56e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg17219203 chr10:38645113 HSD17B7P2 0.41 5.86 0.31 1.12e-8 Extrinsic epigenetic age acceleration; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg07638904 chr22:19166425 SLC25A1 0.42 6.16 0.32 2.07e-9 Mosquito bite size; LUSC trans rs6952808 0.500 rs3800902 chr7:2144378 C/T cg04565464 chr8:145669602 NFKBIL2 0.38 6.08 0.32 3.2e-9 Bipolar disorder and schizophrenia; LUSC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg17719053 chr1:75198211 TYW3;CRYZ 0.41 6.69 0.34 9.52e-11 Resistin levels; LUSC cis rs1577917 0.681 rs4348284 chr6:86350394 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.38 -5.99 -0.31 5.42e-9 Response to antipsychotic treatment; LUSC cis rs12594515 0.874 rs8032878 chr15:45998015 A/G cg06207120 chr15:45996521 NA 0.39 6.04 0.31 4.12e-9 Waist circumference;Weight; LUSC cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.03 -0.44 1.41e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs897984 0.684 rs6950 chr16:30995669 T/C cg02466173 chr16:30829666 NA 0.56 11.25 0.52 4.18e-25 Dementia with Lewy bodies; LUSC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg00409905 chr10:38381863 ZNF37A -0.36 -6.18 -0.32 1.86e-9 Extrinsic epigenetic age acceleration; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg06873352 chr17:61820015 STRADA 0.71 12.54 0.57 8.17e-30 Prudent dietary pattern; LUSC cis rs11153306 0.677 rs10872070 chr6:111921804 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.31 -5.88 -0.31 1.02e-8 Tonsillectomy; LUSC cis rs9549367 0.756 rs2316463 chr13:113901406 C/T cg00898013 chr13:113819073 PROZ -0.55 -7.85 -0.39 5.88e-14 Platelet distribution width; LUSC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg18402987 chr7:1209562 NA 0.68 7.29 0.37 2.28e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11229555 0.645 rs10896785 chr11:58233395 G/A cg15696309 chr11:58395628 NA -0.71 -8.6 -0.43 3.11e-16 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg22437258 chr11:111473054 SIK2 -0.48 -6.62 -0.34 1.44e-10 Primary sclerosing cholangitis; LUSC cis rs7296418 0.961 rs1790121 chr12:123604492 G/A cg00376283 chr12:123451042 ABCB9 0.8 12.14 0.55 2.4e-28 Platelet count; LUSC cis rs6964587 1.000 rs7785095 chr7:91640773 A/T cg17063962 chr7:91808500 NA -0.58 -9.25 -0.45 2.84e-18 Breast cancer; LUSC cis rs240768 1.000 rs3213542 chr6:100966006 C/T cg12253828 chr6:101329408 ASCC3 0.78 5.69 0.3 2.72e-8 Economic and political preferences (immigration/crime); LUSC cis rs13256369 0.865 rs13277708 chr8:8573936 T/C cg15556689 chr8:8085844 FLJ10661 0.44 5.65 0.3 3.37e-8 Obesity-related traits; LUSC cis rs6840360 0.967 rs4383600 chr4:152694383 T/C cg22705602 chr4:152727874 NA -0.27 -5.7 -0.3 2.68e-8 Intelligence (multi-trait analysis); LUSC trans rs3733585 0.699 rs12498150 chr4:9950537 C/T cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.24e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 16.09 0.66 1.53e-43 Platelet count; LUSC cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg16339924 chr4:17578868 LAP3 0.61 9.2 0.45 4.05e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg19257562 chr1:2043853 PRKCZ 0.32 6.28 0.32 1.07e-9 Height; LUSC cis rs12908161 0.959 rs62019472 chr15:85331493 A/G cg17173187 chr15:85201210 NMB 0.48 8.78 0.43 8.71e-17 Schizophrenia; LUSC cis rs1891275 0.508 rs2096079 chr10:93496667 C/G cg07889827 chr10:93443413 NA -0.41 -9.26 -0.45 2.58e-18 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.14 -0.32 2.3e-9 Intelligence (multi-trait analysis); LUSC cis rs2279817 0.863 rs1416854 chr1:18024675 G/A cg21791023 chr1:18019539 ARHGEF10L 0.47 6.47 0.33 3.5e-10 Neuroticism; LUSC cis rs10203711 0.600 rs1810138 chr2:239561888 T/C cg14580085 chr2:239553406 NA 0.41 6.96 0.36 1.79e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6977660 1.000 rs714238 chr7:19803925 C/T cg05791153 chr7:19748676 TWISTNB 0.56 6.24 0.32 1.32e-9 Thyroid stimulating hormone; LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg13628971 chr7:2884303 GNA12 0.47 6.85 0.35 3.67e-11 Height; LUSC cis rs941408 0.515 rs878893 chr19:2781325 A/G cg06609049 chr19:2785107 THOP1 1.15 22.29 0.77 4.43e-68 Total cholesterol levels; LUSC cis rs7819412 0.502 rs4841499 chr8:10988138 A/C cg21775007 chr8:11205619 TDH -0.55 -7.2 -0.37 4.02e-12 Triglycerides; LUSC cis rs9325144 0.510 rs7952795 chr12:38720686 C/T cg13010199 chr12:38710504 ALG10B 0.46 7.16 0.36 5.33e-12 Morning vs. evening chronotype; LUSC trans rs11264799 0.765 rs6427389 chr1:157632011 C/A cg25498969 chr3:136062740 STAG1 -0.24 -6.22 -0.32 1.47e-9 IgA nephropathy; LUSC cis rs440932 1.000 rs378974 chr8:9026639 C/T cg06636001 chr8:8085503 FLJ10661 0.43 6.01 0.31 4.76e-9 High light scatter reticulocyte percentage of red cells; LUSC trans rs7937682 0.632 rs1045282 chr11:111754574 A/C cg18187862 chr3:45730750 SACM1L -0.53 -6.45 -0.33 3.92e-10 Primary sclerosing cholangitis; LUSC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg17264618 chr3:40429014 ENTPD3 0.34 7.2 0.37 4.12e-12 Renal cell carcinoma; LUSC cis rs713477 0.967 rs4901565 chr14:55912508 T/G cg13175173 chr14:55914753 NA -0.32 -6.78 -0.35 5.42e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs67539049 1.000 rs3021517 chr8:11295925 T/C cg02771117 chr8:11279352 FAM167A;C8orf12 -0.38 -5.77 -0.3 1.77e-8 Itch intensity from mosquito bite; LUSC cis rs9503598 0.636 rs7745968 chr6:3467745 G/T cg00476032 chr6:3446245 SLC22A23 0.31 6.03 0.31 4.28e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg06877462 chr1:205807181 PM20D1 0.5 9.04 0.44 1.26e-17 Menarche (age at onset); LUSC cis rs12291225 0.585 rs10832242 chr11:14340504 C/T cg19336497 chr11:14380999 RRAS2 0.62 14.25 0.61 2.57e-36 Sense of smell; LUSC cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg13010199 chr12:38710504 ALG10B 0.7 10.74 0.51 2.65e-23 Bladder cancer; LUSC cis rs722599 0.628 rs12896360 chr14:75278181 A/C cg08847533 chr14:75593920 NEK9 0.44 6.23 0.32 1.41e-9 IgG glycosylation; LUSC cis rs295140 0.605 rs3739119 chr2:201194279 C/A cg23649088 chr2:200775458 C2orf69 -0.37 -5.67 -0.3 3.15e-8 QT interval; LUSC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg03609598 chr5:56110824 MAP3K1 -0.41 -6.01 -0.31 4.78e-9 Initial pursuit acceleration; LUSC trans rs34546498 1 rs34546498 chr6:26961280 C/T cg01620082 chr3:125678407 NA -0.78 -6.6 -0.34 1.59e-10 Breast cancer; LUSC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg02931644 chr1:25747376 RHCE 0.34 6.19 0.32 1.81e-9 Erythrocyte sedimentation rate; LUSC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg02807482 chr3:125708958 NA -0.5 -6.28 -0.32 1.07e-9 Blood pressure (smoking interaction); LUSC cis rs1801251 0.896 rs4973561 chr2:233687337 C/G cg25237894 chr2:233734115 C2orf82 -0.33 -6.1 -0.32 2.94e-9 Coronary artery disease; LUSC trans rs453301 0.653 rs7853 chr8:8890814 A/G cg21775007 chr8:11205619 TDH 0.44 6.17 0.32 2.02e-9 Joint mobility (Beighton score); LUSC cis rs3820928 0.845 rs1917126 chr2:227840923 G/T cg11843606 chr2:227700838 RHBDD1 -0.52 -7.41 -0.38 1.02e-12 Pulmonary function; LUSC cis rs9326248 0.559 rs12808524 chr11:116890993 T/C cg01368799 chr11:117014884 PAFAH1B2 0.61 9.3 0.45 1.88e-18 Blood protein levels; LUSC cis rs11756438 0.572 rs2638544 chr6:119001978 G/A cg18833306 chr6:118973337 C6orf204 0.36 5.75 0.3 2.04e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.64 -0.34 1.27e-10 Lung cancer; LUSC cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.29 0.37 2.24e-12 Motion sickness; LUSC cis rs17433780 0.612 rs7911 chr1:89518120 A/G cg09516651 chr1:89888402 LOC400759 0.59 11.68 0.54 1.16e-26 Carotid intima media thickness; LUSC trans rs7618501 0.633 rs4688689 chr3:50035542 C/T cg21659725 chr3:3221576 CRBN 0.61 9.99 0.48 9.76e-21 Intelligence (multi-trait analysis); LUSC cis rs12210905 0.688 rs72843151 chr6:27359268 A/C cg08851530 chr6:28072375 NA 0.94 6.3 0.33 9.63e-10 Hip circumference adjusted for BMI; LUSC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg02549819 chr16:58548995 SETD6 0.96 9.01 0.44 1.62e-17 Schizophrenia; LUSC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg05347473 chr6:146136440 FBXO30 0.58 10.13 0.48 3.28e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg13206674 chr6:150067644 NUP43 0.61 9.71 0.47 8.23e-20 Lung cancer; LUSC trans rs2018683 0.691 rs4722881 chr7:29001560 A/G cg19402173 chr7:128379420 CALU 0.52 8.21 0.41 4.97e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.27 0.45 2.37e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg21862992 chr11:68658383 NA 0.5 7.95 0.4 2.85e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg16362232 chr11:430036 ANO9 0.6 7.9 0.4 3.97e-14 Body mass index; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg00149659 chr3:10157352 C3orf10 0.97 13.92 0.61 4.88e-35 Alzheimer's disease; LUSC trans rs3733585 0.673 rs4467564 chr4:9953472 G/T cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24833071 chr7:75115655 POM121C -0.54 -7.06 -0.36 9.6e-12 Bipolar disorder and schizophrenia; LUSC cis rs679087 1.000 rs436124 chr12:29916839 C/T cg14258853 chr12:29935411 TMTC1 0.96 16.76 0.68 3.62e-46 Schizophrenia; LUSC cis rs61931739 0.500 rs11052990 chr12:34058647 T/A cg06521331 chr12:34319734 NA -0.47 -7.63 -0.39 2.42e-13 Morning vs. evening chronotype; LUSC cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg23711669 chr6:146136114 FBXO30 -0.89 -16.93 -0.68 7.73e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs17270561 0.636 rs77343532 chr6:25828828 G/A cg16482183 chr6:26056742 HIST1H1C 0.56 7.95 0.4 2.91e-14 Iron status biomarkers; LUSC trans rs853679 0.517 rs34716816 chr6:28046169 C/A cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.97e-17 Motion sickness; LUSC cis rs11676855 0.927 rs4663180 chr2:235921195 A/G cg14917874 chr2:235941519 SH3BP4 0.46 7.48 0.38 6.53e-13 Dialysis-related mortality; LUSC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg12927641 chr6:109611667 NA -0.34 -5.77 -0.3 1.81e-8 Reticulocyte fraction of red cells; LUSC cis rs9547692 0.938 rs7333607 chr13:37462010 A/G cg01034396 chr13:37494802 SMAD9 0.31 5.69 0.3 2.72e-8 Coronary artery disease; LUSC cis rs4948102 0.595 rs7793921 chr7:56120881 G/A cg17215666 chr7:56131930 SUMF2 0.44 5.96 0.31 6.26e-9 Plasma homocysteine levels (post-methionine load test); LUSC cis rs2439831 0.681 rs484029 chr15:43619560 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 10.28 0.49 9.78e-22 Lung cancer in ever smokers; LUSC cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 5.69 0.3 2.8e-8 Rheumatoid arthritis; LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg14092988 chr3:52407081 DNAH1 0.31 6.18 0.32 1.84e-9 Bipolar disorder; LUSC cis rs1775715 0.870 rs1775735 chr10:32255846 A/G cg26784012 chr10:32216390 ARHGAP12 0.4 6.45 0.33 3.85e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7315438 0.557 rs11067596 chr12:115873887 C/T cg24172291 chr12:115889509 NA -0.35 -5.93 -0.31 7.54e-9 Colorectal cancer; LUSC cis rs62458065 0.513 rs10268803 chr7:32547835 A/G cg20159608 chr7:32802032 NA -0.7 -8.96 -0.44 2.41e-17 Metabolite levels (HVA/MHPG ratio); LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg18402987 chr7:1209562 NA 0.74 7.93 0.4 3.36e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg13206674 chr6:150067644 NUP43 0.59 9.15 0.45 5.59e-18 Lung cancer; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg07157834 chr1:205819609 PM20D1 0.86 15.54 0.65 2.33e-41 Menarche (age at onset); LUSC cis rs4654899 0.680 rs6692553 chr1:21221497 C/T cg01072550 chr1:21505969 NA 0.5 7.56 0.38 3.95e-13 Superior frontal gyrus grey matter volume; LUSC cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg08999081 chr20:33150536 PIGU 0.52 10.44 0.5 2.89e-22 Glomerular filtration rate (creatinine); LUSC cis rs11252926 0.800 rs2209625 chr10:747115 A/C cg18196295 chr10:418757 DIP2C -0.41 -6.18 -0.32 1.88e-9 Psychosis in Alzheimer's disease; LUSC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg17173187 chr15:85201210 NMB 0.36 5.88 0.31 9.91e-9 Schizophrenia; LUSC cis rs9527 0.590 rs7894959 chr10:104756182 C/T cg04362960 chr10:104952993 NT5C2 0.58 8.7 0.43 1.52e-16 Arsenic metabolism; LUSC cis rs7582180 0.701 rs11693044 chr2:100922313 T/C cg12002119 chr2:101014098 CHST10 0.34 5.65 0.3 3.52e-8 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.722 rs28458312 chr12:123863265 G/T cg00376283 chr12:123451042 ABCB9 -0.66 -7.62 -0.39 2.56e-13 Neutrophil percentage of white cells; LUSC cis rs12618769 0.597 rs55978998 chr2:99049014 A/G cg10123293 chr2:99228465 UNC50 0.47 7.88 0.4 4.82e-14 Bipolar disorder; LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.19 -0.49 2.13e-21 Platelet count; LUSC cis rs7223966 1.000 rs9893348 chr17:61676534 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.43 5.68 0.3 2.88e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.65 -0.34 1.23e-10 Schizophrenia; LUSC cis rs5769765 0.817 rs11912619 chr22:50317401 G/A cg08270630 chr22:50330655 NA -0.44 -6.62 -0.34 1.43e-10 Schizophrenia; LUSC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg27266027 chr21:40555129 PSMG1 -0.49 -7.35 -0.37 1.54e-12 Cognitive function; LUSC cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg24692254 chr21:30365293 RNF160 0.91 18.48 0.71 5.16e-53 Dental caries; LUSC cis rs1371867 0.846 rs1788204 chr8:101303936 C/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.93e-13 Atrioventricular conduction; LUSC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs41271473 0.526 rs12143098 chr1:228720965 A/C cg10167378 chr1:228756711 NA 0.76 9.72 0.47 8.12e-20 Chronic lymphocytic leukemia; LUSC cis rs2425143 1.000 rs6060588 chr20:34337480 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.32 -0.33 8.4e-10 Blood protein levels; LUSC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg09699651 chr6:150184138 LRP11 0.37 5.76 0.3 1.9e-8 Lung cancer; LUSC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.94 0.36 2.05e-11 Cystic fibrosis severity; LUSC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg22105103 chr4:187893119 NA -0.73 -13.96 -0.61 3.32e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 0.898 rs72782138 chr2:24048162 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg18765753 chr7:1198926 ZFAND2A 0.35 6.15 0.32 2.22e-9 Longevity;Endometriosis; LUSC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg23221052 chr5:179740743 GFPT2 -0.56 -8.8 -0.43 7.69e-17 Height; LUSC cis rs1003719 0.788 rs2251161 chr21:38467857 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.2 0.52 6.39e-25 Eye color traits; LUSC cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg26924012 chr15:45694286 SPATA5L1 1.12 20.31 0.74 2.75e-60 Homoarginine levels; LUSC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg19077165 chr18:44547161 KATNAL2 -0.41 -6.25 -0.32 1.24e-9 Personality dimensions; LUSC cis rs7772486 0.806 rs2265477 chr6:146212338 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.24 -0.37 3.19e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs427394 0.802 rs274712 chr5:6723950 G/A cg10857441 chr5:6722123 POLS -0.47 -9.23 -0.45 3.28e-18 Menopause (age at onset); LUSC cis rs4363385 0.553 rs28924721 chr1:152974254 C/T cg25856811 chr1:152973957 SPRR3 -0.36 -6.04 -0.31 4.02e-9 Inflammatory skin disease; LUSC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg14552801 chr7:65878734 NA -0.39 -6.05 -0.31 3.97e-9 Aortic root size; LUSC trans rs17607347 0.542 rs12325151 chr16:72544825 C/T cg12945194 chr11:64703312 GPHA2 0.37 6.14 0.32 2.36e-9 Intelligence (multi-trait analysis); LUSC cis rs4808199 0.948 rs11085261 chr19:19462606 G/A cg03709012 chr19:19516395 GATAD2A 0.98 11.97 0.55 1.05e-27 Nonalcoholic fatty liver disease; LUSC cis rs7560272 0.695 rs10190002 chr2:73794054 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -7.11 -0.36 7.06e-12 Schizophrenia; LUSC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg13939156 chr17:80058883 NA 0.34 6.53 0.34 2.42e-10 Life satisfaction; LUSC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12825880 chr11:69455671 CCND1 0.44 6.11 0.32 2.85e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13972460 chr20:1165703 C20orf46 -0.44 -6.41 -0.33 4.98e-10 Bipolar disorder and schizophrenia; LUSC cis rs13064411 0.735 rs722392 chr3:113228294 A/G cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.97e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs2070488 0.965 rs2284819 chr3:38557161 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.74 13.27 0.59 1.46e-32 Electrocardiographic conduction measures; LUSC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 10.84 0.51 1.18e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2279817 0.780 rs11585339 chr1:18000120 T/C cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.77 -0.35 5.9e-11 Neuroticism; LUSC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs12220238 1.000 rs2395077 chr10:75932001 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.88 0.35 2.97e-11 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg14548925 chr7:105516956 ATXN7L1 0.43 5.98 0.31 5.69e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs2652822 0.615 rs7174466 chr15:63425019 A/C cg05507819 chr15:63340323 TPM1 0.47 6.03 0.31 4.35e-9 Metabolic traits; LUSC cis rs11018874 0.597 rs4268468 chr11:89886284 C/T cg14505434 chr11:89522851 NA 0.39 6.11 0.32 2.83e-9 White blood cell types; LUSC cis rs701145 0.585 rs896013 chr3:153863873 A/G cg17054900 chr3:154042577 DHX36 0.63 6.18 0.32 1.9e-9 Coronary artery disease; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg24675658 chr1:53192096 ZYG11B -0.55 -8.83 -0.44 5.91e-17 Monocyte count; LUSC cis rs6696846 0.715 rs12139373 chr1:205054879 A/C cg00857998 chr1:205179979 DSTYK 0.61 9.25 0.45 2.78e-18 Red blood cell count; LUSC trans rs3942852 0.568 rs10769313 chr11:48097466 A/G cg03929089 chr4:120376271 NA -0.58 -7.49 -0.38 6.14e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs61931739 0.534 rs73103090 chr12:34098801 C/T cg26384229 chr12:38710491 ALG10B 0.71 11.27 0.52 3.42e-25 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.35 -0.46 1.31e-18 Chronic sinus infection; LUSC cis rs4925386 0.959 rs4925385 chr20:60920624 A/G cg22601191 chr20:60968625 CABLES2 -0.37 -6.03 -0.31 4.33e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs6582630 0.679 rs10785514 chr12:38573689 T/C cg26384229 chr12:38710491 ALG10B 0.58 8.76 0.43 1.03e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs12908161 1.000 rs36033486 chr15:85319692 A/G cg12863693 chr15:85201151 NMB 0.39 8.05 0.4 1.49e-14 Schizophrenia; LUSC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg24110177 chr3:50126178 RBM5 0.64 10.89 0.51 7.98e-24 Body mass index; LUSC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11644478 chr21:40555479 PSMG1 -0.63 -9.64 -0.47 1.46e-19 Menarche (age at onset); LUSC trans rs717267 0.901 rs7026798 chr9:16427378 A/G cg24331049 chr13:111365604 ING1 -0.39 -6.08 -0.32 3.25e-9 Gestational age at birth (maternal effect); LUSC trans rs4332037 0.805 rs10278591 chr7:1921362 A/G cg10840412 chr1:235813424 GNG4 -0.54 -7.54 -0.38 4.54e-13 Bipolar disorder; LUSC trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg21153622 chr11:89784906 NA -0.39 -6.0 -0.31 5.21e-9 HDL cholesterol; LUSC cis rs72829446 0.530 rs4796420 chr17:7379617 A/T cg02795151 chr17:7402630 POLR2A 0.53 6.45 0.33 4.01e-10 Androgen levels; LUSC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.17 -0.32 1.95e-9 Total body bone mineral density; LUSC cis rs10504229 0.679 rs78941440 chr8:58052095 A/G cg11062466 chr8:58055876 NA 0.5 6.81 0.35 4.69e-11 Developmental language disorder (linguistic errors); LUSC cis rs3768617 0.565 rs4652775 chr1:183061825 A/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.78 0.51 1.94e-23 Fuchs's corneal dystrophy; LUSC cis rs9660992 0.710 rs1172136 chr1:205247097 T/G cg21643547 chr1:205240462 TMCC2 -0.51 -9.46 -0.46 5.85e-19 Mean corpuscular volume;Mean platelet volume; LUSC trans rs35110281 0.591 rs162390 chr21:44936826 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.39 0.49 4.18e-22 Mean corpuscular volume; LUSC cis rs929354 0.566 rs6979947 chr7:157005863 C/T cg05182265 chr7:156933206 UBE3C 0.53 7.58 0.38 3.47e-13 Body mass index; LUSC cis rs2835872 0.932 rs73222345 chr21:39036569 G/A cg20424643 chr21:39039972 KCNJ6 0.5 7.55 0.38 4.17e-13 Electroencephalographic traits in alcoholism; LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg10862848 chr6:42927986 GNMT -0.26 -6.37 -0.33 6.25e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7827545 1.000 rs62523736 chr8:135560916 A/T cg17885191 chr8:135476712 NA 0.57 8.37 0.42 1.6e-15 Hypertension (SNP x SNP interaction); LUSC trans rs61931739 0.500 rs11052990 chr12:34058647 T/A cg13010199 chr12:38710504 ALG10B 0.55 8.38 0.42 1.44e-15 Morning vs. evening chronotype; LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg22535103 chr8:58192502 C8orf71 -0.79 -8.22 -0.41 4.44e-15 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.657 rs6107073 chr20:25716363 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.75 14.4 0.62 6.8e-37 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13089785 0.725 rs2222822 chr3:123604788 T/A cg02012769 chr3:123398346 MYLK 0.36 6.4 0.33 5.33e-10 Intelligence (multi-trait analysis); LUSC cis rs9653442 0.900 rs4851269 chr2:100830348 C/T cg07810366 chr2:100720526 AFF3 0.45 7.95 0.4 2.86e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7705502 1.000 rs113932433 chr5:173357206 G/A cg18693985 chr5:173351052 CPEB4 -0.37 -5.82 -0.3 1.35e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7833986 0.534 rs72653924 chr8:56906088 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.68 10.98 0.51 3.87e-24 Height; LUSC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs4722404 0.835 rs28458463 chr7:3139506 G/A cg19214707 chr7:3157722 NA 0.33 6.11 0.32 2.83e-9 Atopic dermatitis; LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg18404041 chr3:52824283 ITIH1 -0.6 -11.54 -0.53 3.65e-26 Bipolar disorder; LUSC cis rs6076065 0.723 rs2424554 chr20:23415867 T/C cg11657817 chr20:23433608 CST11 0.4 7.14 0.36 5.68e-12 Facial morphology (factor 15, philtrum width); LUSC trans rs7939886 0.920 rs12223248 chr11:55887633 A/C cg15704280 chr7:45808275 SEPT13 0.83 6.94 0.36 2e-11 Myopia (pathological); LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs7296418 0.630 rs11608305 chr12:123791165 C/G cg13010344 chr12:123464640 ARL6IP4 -0.49 -7.96 -0.4 2.68e-14 Platelet count; LUSC trans rs9380880 0.826 rs12198307 chr6:39550197 C/T cg19893670 chr10:60097505 UBE2D1 0.65 5.96 0.31 6.24e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg23791538 chr6:167370224 RNASET2 0.41 6.7 0.34 8.84e-11 Crohn's disease; LUSC cis rs877282 0.583 rs112372193 chr10:826602 A/G cg13775593 chr10:823151 NA 0.31 6.26 0.32 1.18e-9 Uric acid levels; LUSC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg05844789 chr1:228464394 OBSCN -0.3 -5.76 -0.3 1.88e-8 Diastolic blood pressure; LUSC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg07701084 chr6:150067640 NUP43 0.55 8.53 0.42 5.01e-16 Lung cancer; LUSC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg05855489 chr10:104503620 C10orf26 -0.65 -9.94 -0.48 1.43e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs34734847 1.000 rs55730005 chr12:121157536 C/A cg27246729 chr12:121163418 ACADS 0.47 7.51 0.38 5.56e-13 Mean corpuscular volume; LUSC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg20283391 chr11:68216788 NA -0.54 -8.03 -0.4 1.69e-14 Total body bone mineral density; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 11.22 0.52 5.31e-25 Alzheimer's disease; LUSC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg17376030 chr22:41985996 PMM1 -0.47 -5.84 -0.3 1.25e-8 Vitiligo; LUSC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg15790184 chr11:494944 RNH1 0.54 6.17 0.32 2e-9 Body mass index; LUSC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg15212455 chr7:39170539 POU6F2 0.65 11.25 0.52 3.95e-25 IgG glycosylation; LUSC cis rs10489525 0.599 rs910622 chr1:115600424 A/G cg01522456 chr1:115632236 TSPAN2 -0.5 -7.23 -0.37 3.26e-12 Autism; LUSC cis rs6599077 1.000 rs9822454 chr3:40095771 C/G cg13683864 chr3:40499215 RPL14 -0.62 -7.86 -0.39 5.47e-14 Sleep-related phenotypes; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.41 0.42 1.2e-15 Prudent dietary pattern; LUSC cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.97 -0.4 2.49e-14 Chronic sinus infection; LUSC cis rs1372520 0.808 rs1372518 chr4:90757294 A/C cg14346243 chr4:90757452 SNCA -0.43 -6.21 -0.32 1.61e-9 Neuroticism; LUSC cis rs28830936 1.000 rs4924575 chr15:42096926 C/T cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.69 -0.3 2.81e-8 Diastolic blood pressure; LUSC cis rs9886651 0.935 rs4427135 chr8:128802021 A/C cg07795030 chr8:128802207 NA -0.34 -6.33 -0.33 8e-10 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg08847533 chr14:75593920 NEK9 -0.8 -13.67 -0.6 4.26e-34 Height; LUSC cis rs4363385 0.626 rs10888531 chr1:153063406 T/C cg07796016 chr1:152779584 LCE1C -0.39 -5.87 -0.31 1.08e-8 Inflammatory skin disease; LUSC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg05425664 chr17:57184151 TRIM37 0.52 7.61 0.38 2.8e-13 Intelligence (multi-trait analysis); LUSC cis rs1775715 0.769 rs2808102 chr10:32117749 A/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.67 0.39 1.89e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg07362569 chr17:61921086 SMARCD2 0.37 7.35 0.37 1.52e-12 Prudent dietary pattern; LUSC cis rs2717559 0.522 rs35816096 chr8:143884938 C/T cg17252645 chr8:143867129 LY6D -0.55 -10.55 -0.5 1.22e-22 Urinary tract infection frequency; LUSC cis rs977987 0.742 rs34624768 chr16:75331572 G/A cg04384234 chr16:75411784 CFDP1 -0.37 -5.94 -0.31 7.31e-9 Dupuytren's disease; LUSC cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg03060546 chr3:49711283 APEH -0.66 -9.69 -0.47 1.02e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg19346786 chr7:2764209 NA -0.38 -6.74 -0.35 6.86e-11 Height; LUSC cis rs751728 0.664 rs2296744 chr6:33740382 G/A cg25922239 chr6:33757077 LEMD2 0.42 6.22 0.32 1.46e-9 Crohn's disease; LUSC cis rs7937682 0.921 rs4616071 chr11:111440865 C/G cg19812747 chr11:111475976 SIK2 0.55 7.68 0.39 1.72e-13 Primary sclerosing cholangitis; LUSC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg13939156 chr17:80058883 NA -0.33 -6.43 -0.33 4.34e-10 Life satisfaction; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg16157530 chr2:105654526 MRPS9 0.51 6.46 0.33 3.71e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2625529 0.824 rs4776581 chr15:72207071 G/A cg16672083 chr15:72433130 SENP8 -0.5 -7.35 -0.37 1.56e-12 Red blood cell count; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg22520471 chr17:61851767 DDX42;CCDC47 -0.6 -9.66 -0.47 1.28e-19 Prudent dietary pattern; LUSC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg03690763 chr11:133734501 NA -0.34 -5.9 -0.31 9.11e-9 Childhood ear infection; LUSC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg09367891 chr1:107599246 PRMT6 -0.55 -8.71 -0.43 1.38e-16 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.23 -0.32 1.37e-9 Lung cancer; LUSC trans rs225245 0.782 rs225272 chr17:33969911 T/C cg19694781 chr19:47549865 TMEM160 -0.41 -6.54 -0.34 2.35e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg00852041 chr4:2420697 ZFYVE28 0.46 5.96 0.31 6.24e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs4969178 0.932 rs3744219 chr17:76400236 G/A cg20026190 chr17:76395443 PGS1 0.45 8.06 0.4 1.4e-14 HDL cholesterol levels; LUSC cis rs202629 1 rs202629 chr22:41849975 C/T cg06850241 chr22:41845214 NA 0.3 5.7 0.3 2.7e-8 Cannabis dependence symptom count; LUSC cis rs1113500 0.805 rs11185244 chr1:108601147 C/T cg06207961 chr1:108661230 NA 0.3 5.65 0.3 3.53e-8 Growth-regulated protein alpha levels; LUSC cis rs662064 0.852 rs2483677 chr1:10580891 C/T cg20482658 chr1:10539492 PEX14 0.33 6.61 0.34 1.54e-10 Asthma; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg00149659 chr3:10157352 C3orf10 0.92 12.28 0.56 7.56e-29 Alzheimer's disease; LUSC cis rs1448094 0.737 rs10863135 chr12:86382657 C/T cg02569458 chr12:86230093 RASSF9 0.4 6.53 0.34 2.48e-10 Major depressive disorder; LUSC cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg00268967 chr12:58002603 GEFT;DTX3 -0.37 -5.82 -0.3 1.4e-8 Celiac disease or Rheumatoid arthritis; LUSC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg05347473 chr6:146136440 FBXO30 0.53 9.28 0.45 2.26e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs3733585 0.682 rs13124563 chr4:9927553 A/G cg26043149 chr18:55253948 FECH 0.46 7.07 0.36 9.25e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.04 0.36 1.11e-11 Tonsillectomy; LUSC cis rs7666738 0.609 rs35214820 chr4:98864692 G/A cg03676636 chr4:99064102 C4orf37 0.32 6.2 0.32 1.67e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1372520 0.564 rs356186 chr4:90705364 A/G cg15133208 chr4:90757351 SNCA -0.53 -7.61 -0.38 2.88e-13 Neuroticism; LUSC cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.52e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs2665103 0.589 rs2134046 chr15:82524544 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.38 -6.09 -0.32 3.19e-9 Intelligence (multi-trait analysis); LUSC cis rs950169 0.845 rs4502182 chr15:84923520 A/G cg17173187 chr15:85201210 NMB 0.38 6.61 0.34 1.52e-10 Schizophrenia; LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg01516881 chr6:292596 DUSP22 -0.52 -7.44 -0.38 8.45e-13 Menopause (age at onset); LUSC cis rs7705502 0.641 rs7731717 chr5:173281685 T/C cg18693985 chr5:173351052 CPEB4 -0.4 -6.35 -0.33 6.86e-10 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs317689 0.718 rs315122 chr12:69771073 G/T cg14784868 chr12:69753453 YEATS4 0.6 7.99 0.4 2.16e-14 Response to diuretic therapy; LUSC cis rs1048238 0.506 rs848209 chr1:16256007 T/C cg22431228 chr1:16359049 CLCNKA 0.42 8.44 0.42 9.8e-16 Systolic blood pressure; LUSC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs3862030 0.694 rs41306870 chr10:104229785 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.97 -0.44 2.18e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs7937682 0.883 rs12366001 chr11:111433916 A/G cg18187862 chr3:45730750 SACM1L -0.53 -6.65 -0.34 1.18e-10 Primary sclerosing cholangitis; LUSC cis rs9341808 0.628 rs1892475 chr6:80862213 T/C cg08355045 chr6:80787529 NA 0.47 8.11 0.41 9.93e-15 Sitting height ratio; LUSC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg17507749 chr15:85114479 UBE2QP1 0.69 8.81 0.43 6.98e-17 Schizophrenia; LUSC cis rs2228479 0.867 rs73276534 chr16:89950557 A/G cg26513180 chr16:89883248 FANCA 0.61 5.84 0.3 1.22e-8 Skin colour saturation; LUSC cis rs965469 0.947 rs965470 chr20:3381588 C/G cg25506879 chr20:3388711 C20orf194 -0.53 -5.74 -0.3 2.11e-8 IFN-related cytopenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02470565 chr22:29702866 GAS2L1 -0.46 -6.47 -0.33 3.45e-10 Bipolar disorder and schizophrenia; LUSC cis rs227833 0.739 rs663933 chr6:44660748 A/G cg20913747 chr6:44695427 NA 0.37 5.88 0.31 9.93e-9 Monobrow; LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.89 0.75 1.43e-62 Prudent dietary pattern; LUSC cis rs4631830 0.720 rs2843560 chr10:51512129 C/G cg10326726 chr10:51549505 MSMB 0.35 6.13 0.32 2.45e-9 Prostate-specific antigen levels; LUSC cis rs8062405 0.755 rs56272201 chr16:28580685 A/G cg16576597 chr16:28551801 NUPR1 0.34 6.77 0.35 5.67e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -7.97 -0.4 2.52e-14 Bone mineral density; LUSC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.52e-8 Extrinsic epigenetic age acceleration; LUSC cis rs12464559 0.649 rs10754989 chr2:152642235 T/C cg01189475 chr2:152685088 ARL5A 0.65 5.95 0.31 6.78e-9 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs10911363 0.509 rs10911339 chr1:183442097 C/T cg09173681 chr1:183549694 NCF2 0.63 11.22 0.52 5.46e-25 Systemic lupus erythematosus; LUSC cis rs4631830 0.683 rs10763193 chr10:51504938 G/A cg10326726 chr10:51549505 MSMB 0.35 6.09 0.32 3.14e-9 Prostate-specific antigen levels; LUSC cis rs710216 0.797 rs841855 chr1:43400176 G/A cg22176566 chr1:43424700 SLC2A1 0.49 6.02 0.31 4.67e-9 Red cell distribution width; LUSC cis rs1215050 0.740 rs783924 chr4:98969234 C/T cg05340658 chr4:99064831 C4orf37 -0.47 -7.44 -0.38 8.74e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg00033643 chr7:134001901 SLC35B4 0.45 6.91 0.35 2.52e-11 Mean platelet volume; LUSC cis rs9303401 0.659 rs35082010 chr17:56936867 A/G cg25039879 chr17:56429692 SUPT4H1 0.68 9.11 0.45 7.7e-18 Cognitive test performance; LUSC cis rs10979 1.000 rs9285500 chr6:143897614 G/C cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC trans rs7944735 0.507 rs7396592 chr11:48100837 T/C cg15704280 chr7:45808275 SEPT13 -0.61 -7.53 -0.38 4.82e-13 Intraocular pressure; LUSC cis rs8141529 0.843 rs1065497 chr22:29279991 C/T cg15103426 chr22:29168792 CCDC117 0.52 6.45 0.33 3.99e-10 Lymphocyte counts; LUSC cis rs7582180 0.638 rs9973536 chr2:100942243 C/T cg08017756 chr2:100939284 LONRF2 -0.44 -8.24 -0.41 3.91e-15 Intelligence (multi-trait analysis); LUSC cis rs4851254 0.584 rs35774174 chr2:100655130 T/A cg07810366 chr2:100720526 AFF3 -0.46 -5.98 -0.31 5.87e-9 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.954 rs71614438 chr4:120371252 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs10072221 0.805 rs11744637 chr5:75705895 C/T cg03132911 chr5:75698732 IQGAP2 0.37 6.24 0.32 1.3e-9 Mean platelet volume; LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg16405210 chr4:1374714 KIAA1530 -0.45 -6.64 -0.34 1.25e-10 Obesity-related traits; LUSC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.88 15.29 0.64 2.21e-40 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs7939886 0.920 rs59300271 chr11:55961792 G/A cg03929089 chr4:120376271 NA 0.81 6.11 0.32 2.73e-9 Myopia (pathological); LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg14092988 chr3:52407081 DNAH1 0.32 5.89 0.31 9.55e-9 Bipolar disorder; LUSC cis rs600231 0.542 rs11227199 chr11:65238121 G/A cg17120908 chr11:65337727 SSSCA1 -0.62 -8.95 -0.44 2.47e-17 Bone mineral density; LUSC cis rs362272 0.524 rs2857982 chr4:3358665 G/A cg18352616 chr4:3374830 RGS12 0.32 6.31 0.33 9.03e-10 Serum sulfate level; LUSC cis rs9479482 1.000 rs11155697 chr6:150357423 C/T cg03788504 chr6:150331562 NA -0.26 -5.84 -0.3 1.22e-8 Alopecia areata; LUSC cis rs2731664 0.792 rs466256 chr5:176875956 C/A cg23176889 chr5:176863531 GRK6 -0.66 -13.4 -0.59 4.44e-33 Intelligence (multi-trait analysis); LUSC trans rs12310956 0.510 rs10743832 chr12:33884146 A/C cg13010199 chr12:38710504 ALG10B 0.44 6.71 0.34 8.41e-11 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06452451 chr5:74062824 NSA2;GFM2 -0.42 -6.29 -0.33 9.92e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7107174 0.892 rs2512548 chr11:77962116 A/G cg02023728 chr11:77925099 USP35 0.45 6.68 0.34 9.85e-11 Testicular germ cell tumor; LUSC cis rs2200578 1.000 rs62153845 chr2:99887162 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.53 6.19 0.32 1.72e-9 IgG glycosylation; LUSC cis rs7089973 0.549 rs7094440 chr10:116745408 T/C cg23260525 chr10:116636907 FAM160B1 0.3 5.79 0.3 1.61e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs208520 0.690 rs12213561 chr6:66705646 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.06 16.59 0.67 1.7e-45 Exhaled nitric oxide output; LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg16325326 chr1:53192061 ZYG11B -0.86 -15.96 -0.66 5.09e-43 Monocyte count; LUSC cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.5e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs62400317 0.826 rs62400330 chr6:45321455 G/A cg20913747 chr6:44695427 NA -0.47 -7.73 -0.39 1.24e-13 Total body bone mineral density; LUSC cis rs672059 1.000 rs566625 chr1:183161441 A/G ch.1.3577855R chr1:183094577 LAMC1 0.58 8.52 0.42 5.4e-16 Hypertriglyceridemia; LUSC cis rs12594515 1.000 rs8033148 chr15:45997929 G/A cg19682013 chr15:45996608 NA 0.39 5.84 0.3 1.24e-8 Waist circumference;Weight; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg18758796 chr5:131593413 PDLIM4 0.41 6.69 0.34 9.39e-11 Breast cancer; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.84 0.44 5.47e-17 Prudent dietary pattern; LUSC cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.62 -0.47 1.73e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2120019 0.567 rs8025170 chr15:75170983 A/G cg09165964 chr15:75287851 SCAMP5 0.86 10.23 0.49 1.5e-21 Blood trace element (Zn levels); LUSC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg27494647 chr7:150038898 RARRES2 0.6 8.82 0.43 6.47e-17 Blood protein levels;Circulating chemerin levels; LUSC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.63 0.5 6.52e-23 Monocyte percentage of white cells; LUSC cis rs2243480 0.522 rs1638736 chr7:66092308 A/T cg18252515 chr7:66147081 NA -1.16 -8.5 -0.42 6.44e-16 Diabetic kidney disease; LUSC cis rs11971779 0.616 rs7779314 chr7:139112696 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs662064 0.748 rs2506892 chr1:10598216 G/A cg20482658 chr1:10539492 PEX14 0.33 6.6 0.34 1.66e-10 Asthma; LUSC cis rs4984778 0.750 rs7198064 chr16:1272472 C/T cg07748719 chr16:1272498 TPSG1 0.75 14.47 0.62 3.51e-37 Blood protein levels; LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg19318889 chr4:1322082 MAEA 0.43 6.99 0.36 1.46e-11 Obesity-related traits; LUSC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg04287289 chr16:89883240 FANCA 0.78 13.43 0.59 3.64e-33 Vitiligo; LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg13560548 chr3:10150139 C3orf24 0.55 7.27 0.37 2.55e-12 Alzheimer's disease; LUSC cis rs17685 0.753 rs12531559 chr7:75631697 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.52 8.0 0.4 2.06e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs5769707 0.967 rs9616713 chr22:50049109 G/A cg14507445 chr22:49886340 NA -0.29 -5.72 -0.3 2.37e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg24846343 chr22:24311635 DDTL 0.76 16.7 0.67 6.16e-46 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4780355 0.877 rs243317 chr16:11357331 G/T cg00044050 chr16:11439710 C16orf75 -0.55 -8.13 -0.41 8.34e-15 Crohn's disease and psoriasis; LUSC cis rs3857536 0.719 rs9363555 chr6:66930332 T/C cg07460842 chr6:66804631 NA -0.47 -6.49 -0.33 3.18e-10 Blood trace element (Cu levels); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20242210 chr6:122931702 PKIB -0.51 -6.4 -0.33 5.15e-10 Bipolar disorder and schizophrenia; LUSC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg19717773 chr7:2847554 GNA12 -0.39 -6.12 -0.32 2.61e-9 Height; LUSC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg13010199 chr12:38710504 ALG10B 0.61 9.52 0.46 3.64e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs12586317 0.534 rs1568200 chr14:35419592 C/T cg16230307 chr14:35515116 FAM177A1 0.51 6.39 0.33 5.69e-10 Psoriasis; LUSC cis rs738321 0.671 rs3761446 chr22:38595483 G/A cg25457927 chr22:38595422 NA -0.46 -8.94 -0.44 2.7e-17 Breast cancer; LUSC cis rs61990749 0.597 rs12887606 chr14:78200620 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.59 6.44 0.33 4.08e-10 Fibroblast growth factor basic levels; LUSC cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9359856 0.564 rs72913976 chr6:90390233 T/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.89 -0.44 3.8e-17 Bipolar disorder; LUSC cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg00321850 chr1:175162397 KIAA0040 -0.45 -7.72 -0.39 1.39e-13 Alcohol dependence; LUSC cis rs911119 0.955 rs55897275 chr20:23595953 A/T cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs9888739 0.800 rs7193268 chr16:31340997 A/G cg15817542 chr16:31343056 ITGAM 0.44 6.04 0.31 4.02e-9 Systemic lupus erythematosus; LUSC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -12.57 -0.57 6.41e-30 Extrinsic epigenetic age acceleration; LUSC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs2219968 1.000 rs1073445 chr8:78959745 T/C cg00738934 chr8:78996279 NA 0.35 6.21 0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs877282 0.838 rs34778553 chr10:796865 T/C cg17470449 chr10:769945 NA 0.48 6.79 0.35 5.12e-11 Uric acid levels; LUSC cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg08085267 chr17:45401833 C17orf57 -0.56 -8.48 -0.42 7.23e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1559088 0.847 rs8100392 chr19:33605933 T/C cg17764715 chr19:33622953 WDR88 0.62 8.47 0.42 8.16e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.72 7.59 0.38 3.32e-13 Initial pursuit acceleration; LUSC cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg17063962 chr7:91808500 NA 0.58 9.28 0.45 2.15e-18 Breast cancer; LUSC cis rs3849570 0.961 rs3849571 chr3:81777716 A/C cg07356753 chr3:81810745 GBE1 -0.7 -11.34 -0.53 1.98e-25 Waist circumference;Body mass index; LUSC cis rs1014246 0.813 rs11197797 chr10:118454499 C/T cg14919929 chr10:118506882 NA 0.47 7.29 0.37 2.27e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs868036 1.000 rs4776376 chr15:68093435 G/A cg08079166 chr15:68083412 MAP2K5 0.41 8.49 0.42 6.72e-16 Restless legs syndrome; LUSC cis rs4474465 0.688 rs7945812 chr11:78280509 T/C cg27205649 chr11:78285834 NARS2 0.59 7.39 0.37 1.23e-12 Alzheimer's disease (survival time); LUSC trans rs8073060 1.000 rs8073060 chr17:33875262 T/A cg19694781 chr19:47549865 TMEM160 0.67 10.13 0.48 3.24e-21 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg16103275 chr6:290800 DUSP22 0.41 7.01 0.36 1.34e-11 Menopause (age at onset); LUSC cis rs9815354 0.812 rs59146151 chr3:41949301 T/C cg03022575 chr3:42003672 ULK4 0.81 8.49 0.42 6.81e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg23711669 chr6:146136114 FBXO30 0.83 15.28 0.64 2.41e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC trans rs9929218 0.954 rs9928796 chr16:68820718 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -11.06 -0.52 1.97e-24 Colorectal cancer; LUSC cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg15839431 chr19:19639596 YJEFN3 -0.68 -7.44 -0.38 8.49e-13 Bipolar disorder; LUSC cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg09035930 chr12:129282057 SLC15A4 0.74 16.34 0.67 1.65e-44 Systemic lupus erythematosus; LUSC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11890956 chr21:40555474 PSMG1 1.04 20.73 0.75 5.84e-62 Cognitive function; LUSC cis rs11997175 0.655 rs4380889 chr8:33663381 C/T ch.8.33884649F chr8:33765107 NA 0.37 5.65 0.3 3.37e-8 Body mass index; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg00684032 chr4:1343700 KIAA1530 0.35 6.36 0.33 6.77e-10 Obesity-related traits; LUSC trans rs1493916 0.967 rs9953765 chr18:31399464 A/G cg13755796 chr4:20253514 NA -0.43 -6.6 -0.34 1.59e-10 Life satisfaction; LUSC cis rs9325144 0.600 rs6582630 chr12:38743508 A/G cg13010199 chr12:38710504 ALG10B -0.47 -7.24 -0.37 3.1e-12 Morning vs. evening chronotype; LUSC cis rs13082711 0.596 rs683503 chr3:27348094 C/T cg02860705 chr3:27208620 NA 0.51 9.16 0.45 5.29e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg02951883 chr7:2050386 MAD1L1 -0.6 -10.97 -0.51 4.02e-24 Bipolar disorder and schizophrenia; LUSC trans rs1908814 0.503 rs34657250 chr8:11795373 A/G cg08975724 chr8:8085496 FLJ10661 -0.51 -7.46 -0.38 7.48e-13 Neuroticism; LUSC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg06481639 chr22:41940642 POLR3H 0.5 5.77 0.3 1.81e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.58e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg01879757 chr17:41196368 BRCA1 -0.45 -6.85 -0.35 3.63e-11 Menopause (age at onset); LUSC trans rs11039798 0.920 rs9667596 chr11:48691193 T/C cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs8179 0.648 rs42036 chr7:92241451 C/G cg15732164 chr7:92237376 CDK6 -0.47 -6.53 -0.34 2.42e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs748404 0.578 rs512628 chr15:43618734 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.45 6.07 0.32 3.55e-9 Lung cancer; LUSC cis rs11122272 0.735 rs2739509 chr1:231526765 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs2625529 0.689 rs12161990 chr15:72202440 T/C cg16672083 chr15:72433130 SENP8 0.49 7.86 0.4 5.21e-14 Red blood cell count; LUSC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg24154853 chr7:158122151 PTPRN2 0.45 8.87 0.44 4.48e-17 Calcium levels; LUSC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs6845621 0.727 rs11944667 chr4:18911211 A/T cg12196642 chr4:18937545 NA -0.34 -6.34 -0.33 7.28e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg16339924 chr4:17578868 LAP3 -0.5 -7.69 -0.39 1.72e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs208520 0.690 rs7764570 chr6:66827600 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -15.37 -0.64 1.06e-40 Exhaled nitric oxide output; LUSC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.79 0.39 8.71e-14 Hip circumference adjusted for BMI; LUSC cis rs9549260 0.755 rs2721045 chr13:41162632 T/A cg21288729 chr13:41239152 FOXO1 0.6 9.22 0.45 3.31e-18 Red blood cell count; LUSC cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg04455712 chr21:45112962 RRP1B 0.46 8.84 0.44 5.73e-17 Mean corpuscular volume; LUSC trans rs10802346 0.545 rs6662672 chr1:246387611 A/C cg22732515 chr19:44031385 ETHE1 0.64 10.53 0.5 1.38e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs367615 0.506 rs2914680 chr5:108787146 A/G cg17395555 chr5:108820864 NA -0.52 -9.75 -0.47 6.33e-20 Colorectal cancer (SNP x SNP interaction); LUSC cis rs870825 0.616 rs2130393 chr4:185642335 T/C cg04058563 chr4:185651563 MLF1IP 0.86 13.27 0.59 1.42e-32 Blood protein levels; LUSC cis rs34638657 0.702 rs11866709 chr16:82201017 A/G cg09439754 chr16:82129088 HSD17B2 -0.39 -6.33 -0.33 7.89e-10 Lung adenocarcinoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22854549 chr19:5904785 VMAC;NDUFA11 0.42 6.59 0.34 1.74e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg23172400 chr8:95962367 TP53INP1 -0.4 -8.09 -0.4 1.12e-14 Type 2 diabetes; LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg17968037 chr7:100024898 ZCWPW1 -0.41 -6.17 -0.32 2.02e-9 Platelet count; LUSC cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 6.07 0.32 3.55e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs936229 0.861 rs7176022 chr15:75107880 G/T cg10253484 chr15:75165896 SCAMP2 0.52 7.2 0.37 4.09e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs73001065 0.892 rs58542926 chr19:19379549 C/T cg03709012 chr19:19516395 GATAD2A 0.88 6.41 0.33 4.95e-10 LDL cholesterol; LUSC cis rs4629180 1.000 rs6744495 chr2:102099956 T/C cg01388757 chr2:102091195 RFX8 -0.45 -7.06 -0.36 9.48e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs9549260 0.755 rs17061450 chr13:41183716 G/A cg21288729 chr13:41239152 FOXO1 0.59 8.95 0.44 2.45e-17 Red blood cell count; LUSC cis rs9420 0.961 rs71484468 chr11:57632799 G/C cg02958346 chr11:57425731 CLP1 -0.44 -6.28 -0.33 1.04e-9 Schizophrenia; LUSC trans rs7690543 0.681 rs6552075 chr4:68008700 A/C cg06097370 chr10:21604082 NA -0.68 -6.02 -0.31 4.62e-9 Glucose homeostasis traits; LUSC trans rs2739330 0.828 rs2186366 chr22:24254113 A/G cg06437703 chr8:37914619 EIF4EBP1 0.56 8.61 0.43 3.02e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs713587 0.525 rs1541984 chr2:25082414 G/A cg04586622 chr2:25135609 ADCY3 0.37 7.73 0.39 1.25e-13 Body mass index in non-asthmatics; LUSC cis rs394563 0.591 rs237012 chr6:149729198 T/C cg07828024 chr6:149772892 ZC3H12D -0.33 -7.24 -0.37 3.16e-12 Dupuytren's disease; LUSC cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg24642439 chr20:33292090 TP53INP2 0.69 10.7 0.51 3.61e-23 Coronary artery disease; LUSC cis rs9399135 0.967 rs2297338 chr6:135375762 G/A cg24558204 chr6:135376177 HBS1L 0.59 9.09 0.45 9.11e-18 Red blood cell count; LUSC cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg03060546 chr3:49711283 APEH -0.7 -10.2 -0.49 1.88e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs710216 0.763 rs9438964 chr1:43443742 C/T cg22176566 chr1:43424700 SLC2A1 0.46 5.86 0.31 1.08e-8 Red cell distribution width; LUSC trans rs6502050 0.835 rs7503189 chr17:80099486 C/A cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg11645453 chr3:52864694 ITIH4 0.3 6.9 0.35 2.7e-11 Electroencephalogram traits; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg06675538 chr2:114033490 PAX8;LOC440839 -0.32 -5.69 -0.3 2.81e-8 Lymphocyte counts; LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg11062466 chr8:58055876 NA 0.51 6.54 0.34 2.27e-10 Developmental language disorder (linguistic errors); LUSC cis rs7927592 0.913 rs7109294 chr11:68332093 A/G cg20283391 chr11:68216788 NA -0.59 -8.26 -0.41 3.43e-15 Total body bone mineral density; LUSC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg11941060 chr3:133502564 NA -0.52 -8.04 -0.4 1.53e-14 Iron status biomarkers; LUSC cis rs983392 0.709 rs1349667 chr11:59993346 T/A cg24026212 chr11:59952134 MS4A6A -0.36 -6.11 -0.32 2.79e-9 Alzheimer's disease (late onset); LUSC cis rs3750082 0.582 rs3750079 chr7:32969419 G/A cg08946731 chr7:32981826 RP9P 0.41 6.58 0.34 1.77e-10 Glomerular filtration rate (creatinine); LUSC cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg08027265 chr7:2291960 NA -0.64 -11.86 -0.54 2.55e-27 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg22437258 chr11:111473054 SIK2 0.44 5.67 0.3 3.11e-8 Primary sclerosing cholangitis; LUSC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -13.89 -0.61 5.93e-35 Coronary artery disease; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.62 7.25 0.37 3e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs79057730 0.599 rs6951032 chr7:794092 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.83 8.51 0.42 6.06e-16 Initial pursuit acceleration; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.72 -11.87 -0.54 2.4e-27 Prudent dietary pattern; LUSC trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg03929089 chr4:120376271 NA -0.87 -11.94 -0.55 1.34e-27 Height; LUSC cis rs9467711 0.659 rs3823158 chr6:26463271 T/A cg09904177 chr6:26538194 HMGN4 -0.8 -6.37 -0.33 6.31e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg10172584 chr19:19639581 YJEFN3 -0.46 -5.65 -0.3 3.42e-8 Bipolar disorder; LUSC cis rs11098499 0.908 rs12504149 chr4:120318577 G/A cg09307838 chr4:120376055 NA 0.79 11.38 0.53 1.46e-25 Corneal astigmatism; LUSC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg08280861 chr8:58055591 NA 0.58 6.38 0.33 6.01e-10 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg06850241 chr22:41845214 NA -0.31 -5.92 -0.31 7.92e-9 Vitiligo; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg17541715 chr7:1216824 NA -0.37 -5.69 -0.3 2.72e-8 Longevity;Endometriosis; LUSC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs7084402 1.000 rs12250013 chr10:60265957 C/A cg07615347 chr10:60278583 BICC1 -0.34 -5.64 -0.3 3.54e-8 Refractive error; LUSC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06544989 chr22:39130855 UNC84B 0.32 5.68 0.3 2.92e-8 Menopause (age at onset); LUSC cis rs9372253 0.645 rs7753212 chr6:110700229 T/C cg00083206 chr6:110721305 DDO -0.43 -7.69 -0.39 1.66e-13 Platelet distribution width; LUSC cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg04455712 chr21:45112962 RRP1B -0.4 -7.67 -0.39 1.85e-13 Mean corpuscular volume; LUSC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg19920283 chr7:105172520 RINT1 0.61 6.67 0.34 1.07e-10 Bipolar disorder (body mass index interaction); LUSC cis rs6539267 0.741 rs10861572 chr12:106688576 A/G cg02476566 chr12:106696527 TCP11L2 -0.49 -6.15 -0.32 2.21e-9 Tourette syndrome; LUSC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg23630131 chr7:65973040 NA 0.21 5.83 0.3 1.33e-8 Aortic root size; LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg00149659 chr3:10157352 C3orf10 0.89 12.11 0.55 3.04e-28 Alzheimer's disease; LUSC cis rs9527 0.545 rs7915816 chr10:104881750 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs877282 0.786 rs10904558 chr10:797509 C/T cg17470449 chr10:769945 NA 0.47 6.68 0.34 1.01e-10 Uric acid levels; LUSC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg18681998 chr4:17616180 MED28 0.84 15.62 0.65 1.13e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11098499 1.000 rs13116504 chr4:120209412 A/C cg09307838 chr4:120376055 NA 0.68 9.78 0.47 4.89e-20 Corneal astigmatism; LUSC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.73 10.84 0.51 1.14e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg26647111 chr11:31128758 NA 0.41 6.11 0.32 2.71e-9 Red blood cell count; LUSC cis rs559928 0.606 rs76653616 chr11:63936139 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.25 0.37 2.93e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9790314 0.967 rs7623206 chr3:160971518 G/A cg04691961 chr3:161091175 C3orf57 -0.34 -5.81 -0.3 1.49e-8 Morning vs. evening chronotype; LUSC cis rs7833986 0.501 rs72653951 chr8:56961837 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.32 0.56 5.37e-29 Height; LUSC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs2637266 0.756 rs846607 chr10:78561254 A/T cg18941641 chr10:78392320 NA 0.38 6.91 0.35 2.41e-11 Pulmonary function; LUSC cis rs7909074 0.898 rs10793565 chr10:45388231 G/C cg04218760 chr10:45406644 TMEM72 -0.32 -7.77 -0.39 9.91e-14 Mean corpuscular volume; LUSC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg09034736 chr1:150693464 HORMAD1 0.42 5.79 0.3 1.63e-8 Melanoma; LUSC cis rs2835872 0.832 rs857978 chr21:38998126 A/G cg20424643 chr21:39039972 KCNJ6 -0.37 -5.83 -0.3 1.28e-8 Electroencephalographic traits in alcoholism; LUSC trans rs2392780 0.514 rs653605 chr8:128338847 G/T cg10897648 chr18:56338258 MALT1 -0.42 -6.35 -0.33 6.95e-10 Breast cancer (early onset); LUSC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg05623727 chr3:50126028 RBM5 -0.33 -6.14 -0.32 2.32e-9 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs7078799 chr10:102301447 G/A cg16342193 chr10:102329863 NA -0.34 -5.94 -0.31 7.31e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.12 0.36 6.6e-12 Platelet count; LUSC cis rs68170813 0.559 rs9641378 chr7:106868003 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.63 -0.47 1.62e-19 Coronary artery disease; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.56e-29 Prudent dietary pattern; LUSC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg24642844 chr7:1081250 C7orf50 -0.46 -7.42 -0.38 9.8e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8016982 0.698 rs12590764 chr14:81704417 G/A cg01989461 chr14:81687754 GTF2A1 0.67 11.01 0.52 2.81e-24 Schizophrenia; LUSC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg10523679 chr1:76189770 ACADM -0.85 -11.4 -0.53 1.18e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17253792 0.822 rs78522049 chr14:56071203 A/C cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.9e-12 Putamen volume; LUSC cis rs6964587 0.967 rs7783414 chr7:91785957 C/T cg01689657 chr7:91764605 CYP51A1 0.32 5.83 0.3 1.3e-8 Breast cancer; LUSC cis rs3806843 0.548 rs246058 chr5:140325134 G/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.15 0.41 7.34e-15 Axial length; LUSC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg12463550 chr7:65579703 CRCP -0.51 -7.45 -0.38 7.92e-13 Aortic root size; LUSC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 11.12 0.52 1.17e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11190604 1.000 rs2489045 chr10:102344754 C/T cg07080220 chr10:102295463 HIF1AN 0.68 8.84 0.44 5.7e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12545109 0.800 rs1440763 chr8:57410481 C/A cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.1e-10 Obesity-related traits; LUSC trans rs8002861 0.935 rs4942256 chr13:44455920 A/T cg12856521 chr11:46389249 DGKZ 0.4 6.27 0.32 1.09e-9 Leprosy; LUSC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg13939156 chr17:80058883 NA 0.34 6.69 0.34 9.61e-11 Life satisfaction; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg13395646 chr4:1353034 KIAA1530 -0.59 -8.45 -0.42 9.09e-16 Longevity; LUSC cis rs7904985 1.000 rs11201991 chr10:88117122 T/C cg07322936 chr10:88137208 NA -0.57 -7.23 -0.37 3.37e-12 Barrett's esophagus; LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03576123 chr11:487126 PTDSS2 -1.0 -10.52 -0.5 1.48e-22 Body mass index; LUSC cis rs9733 0.650 rs12125672 chr1:150554470 A/T cg09365446 chr1:150670422 GOLPH3L -0.41 -5.94 -0.31 7.13e-9 Tonsillectomy; LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg20295408 chr7:1910781 MAD1L1 0.42 5.97 0.31 6.14e-9 Bipolar disorder and schizophrenia; LUSC cis rs12493885 0.818 rs60023390 chr3:153771056 C/T cg17054900 chr3:154042577 DHX36 -0.53 -5.71 -0.3 2.51e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.65 -10.29 -0.49 9.74e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3931020 0.688 rs277396 chr1:75213648 A/C cg21535942 chr1:75199100 CRYZ;TYW3 -0.48 -6.03 -0.31 4.37e-9 Resistin levels; LUSC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs11098499 0.865 rs11722183 chr4:120280597 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.56 0.34 2.07e-10 Corneal astigmatism; LUSC cis rs12145833 0.538 rs10754798 chr1:243309958 A/G cg02356786 chr1:243265016 LOC731275 -0.7 -6.94 -0.35 2.08e-11 Obesity (early onset extreme); LUSC cis rs9325144 0.600 rs7312522 chr12:38730423 A/G cg26384229 chr12:38710491 ALG10B 0.6 9.49 0.46 4.46e-19 Morning vs. evening chronotype; LUSC cis rs9814567 1.000 rs7630874 chr3:134293291 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg26380479 chr7:97908229 NA -0.27 -6.03 -0.31 4.29e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3847687 1.000 rs3847687 chr12:131525053 C/T cg25772418 chr12:131519998 GPR133 -0.27 -5.97 -0.31 5.93e-9 Longevity; LUSC cis rs9807989 0.524 rs2110662 chr2:103020139 A/T cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg00945038 chr17:61921165 SMARCD2 0.54 9.64 0.47 1.4e-19 Prudent dietary pattern; LUSC cis rs7804356 1.000 rs73065504 chr7:26825984 A/G cg03456212 chr7:26904342 SKAP2 -0.55 -6.53 -0.34 2.41e-10 Type 1 diabetes; LUSC cis rs11971779 0.553 rs10228643 chr7:139115420 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs11148252 0.508 rs6561671 chr13:53182314 G/A cg00495681 chr13:53174319 NA 0.75 14.27 0.62 2.09e-36 Lewy body disease; LUSC cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.13 0.66 1.09e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs11971779 0.617 rs66652773 chr7:139109573 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg24531977 chr5:56204891 C5orf35 -1.04 -15.55 -0.65 2.19e-41 Initial pursuit acceleration; LUSC cis rs12579753 0.913 rs7965664 chr12:82237340 G/T cg21231944 chr12:82153410 PPFIA2 -0.38 -5.76 -0.3 1.94e-8 Resting heart rate; LUSC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.42 0.5 3.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11039798 0.925 rs10769373 chr11:48531980 T/A cg15704280 chr7:45808275 SEPT13 0.73 6.92 0.35 2.32e-11 Axial length; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg05617413 chr12:133065912 FBRSL1 0.33 5.96 0.31 6.53e-9 Metabolite levels (Pyroglutamine); LUSC cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC cis rs75804782 0.521 rs56227677 chr2:239449867 C/T cg18131467 chr2:239335373 ASB1 -0.64 -5.95 -0.31 6.69e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.23 0.32 1.39e-9 Systolic blood pressure; LUSC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg07741184 chr6:167504864 NA 0.35 6.22 0.32 1.5e-9 Crohn's disease; LUSC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg06108461 chr20:60628389 TAF4 -0.74 -11.88 -0.54 2.19e-27 Body mass index; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg12419862 chr22:24373484 LOC391322 -0.94 -17.89 -0.7 1.14e-50 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg27170947 chr2:26402098 FAM59B 0.64 8.96 0.44 2.35e-17 Gut microbiome composition (summer); LUSC cis rs8025790 0.508 rs28673019 chr15:67809823 T/A cg24579218 chr15:68104479 NA -0.34 -5.74 -0.3 2.18e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg13902645 chr11:5959945 NA -0.55 -8.63 -0.43 2.55e-16 DNA methylation (variation); LUSC cis rs75920871 0.588 rs3181 chr11:116907043 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.5 -0.33 2.99e-10 Subjective well-being; LUSC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg03060546 chr3:49711283 APEH -0.69 -11.75 -0.54 6.3100000000000004e-27 Resting heart rate; LUSC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1568889 1.000 rs9783375 chr11:28033667 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 8.7 0.43 1.52e-16 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24702147 chr12:7071814 MIR141;MIR200C 0.27 6.46 0.33 3.63e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7939886 0.920 rs11227598 chr11:56000451 G/A cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs10743315 0.599 rs11044451 chr12:19365798 C/T cg02471346 chr12:19282374 PLEKHA5 -0.62 -7.38 -0.37 1.27e-12 Gut microbiota (bacterial taxa); LUSC trans rs9329221 0.510 rs4841282 chr8:9975604 C/A cg06636001 chr8:8085503 FLJ10661 0.47 6.96 0.36 1.84e-11 Neuroticism; LUSC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -8.91 -0.44 3.25e-17 Schizophrenia; LUSC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg10802521 chr3:52805072 NEK4 -0.55 -8.9 -0.44 3.51e-17 Electroencephalogram traits; LUSC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.77 13.5 0.59 1.85e-33 Total body bone mineral density; LUSC trans rs11098499 0.863 rs2127823 chr4:120485670 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.6 0.34 1.63e-10 Corneal astigmatism; LUSC cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.25 0.49 1.32e-21 Bladder cancer; LUSC cis rs757110 0.648 rs12146443 chr11:17384498 T/C cg15432903 chr11:17409602 KCNJ11 0.6 10.66 0.5 4.88e-23 Type 2 diabetes; LUSC cis rs2540226 0.844 rs4670959 chr2:39993167 T/C cg23576258 chr2:39999331 THUMPD2 0.35 5.85 0.3 1.18e-8 Personality dimensions; LUSC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg05738196 chr6:26577821 NA -0.81 -15.03 -0.64 2.27e-39 Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg18681998 chr4:17616180 MED28 -0.81 -14.86 -0.63 1.08e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs600231 0.508 rs11227202 chr11:65242717 G/A cg17120908 chr11:65337727 SSSCA1 -0.62 -8.95 -0.44 2.47e-17 Bone mineral density; LUSC trans rs11098499 0.909 rs1546504 chr4:120241179 C/T cg25214090 chr10:38739885 LOC399744 0.58 8.51 0.42 6.08e-16 Corneal astigmatism; LUSC trans rs11039798 0.699 rs7120775 chr11:48266736 C/G cg03929089 chr4:120376271 NA 0.66 6.25 0.32 1.23e-9 Axial length; LUSC cis rs4737010 0.570 rs7823138 chr8:41644861 C/T cg17182837 chr8:41585554 ANK1 0.33 6.31 0.33 9.07e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg14004847 chr7:1930337 MAD1L1 -0.53 -7.87 -0.4 5.03e-14 Bipolar disorder and schizophrenia; LUSC cis rs12541635 0.966 rs2345070 chr8:107072027 A/G cg10147462 chr8:107024639 NA -0.53 -9.38 -0.46 1.05e-18 Age of smoking initiation; LUSC cis rs7872515 1.000 rs7872515 chr9:94822540 A/G cg01248375 chr9:94877805 SPTLC1 -0.54 -5.68 -0.3 3e-8 Bipolar disorder and schizophrenia; LUSC cis rs73198271 0.603 rs557892 chr8:8596048 A/C cg01851573 chr8:8652454 MFHAS1 0.42 6.26 0.32 1.2e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10843647 1.000 rs6487884 chr12:30324920 G/T cg12718339 chr12:29936407 TMTC1 -0.36 -5.91 -0.31 8.65e-9 Glucose homeostasis traits; LUSC cis rs7202877 0.706 rs37605 chr16:75506572 G/C cg03315344 chr16:75512273 CHST6 -0.43 -6.23 -0.32 1.38e-9 Type 2 diabetes;Type 1 diabetes; LUSC trans rs7937682 0.632 rs7128862 chr11:111755435 C/T cg18187862 chr3:45730750 SACM1L -0.53 -6.45 -0.33 3.92e-10 Primary sclerosing cholangitis; LUSC trans rs393155 0.517 rs330050 chr8:9087679 G/C cg21775007 chr8:11205619 TDH -0.44 -6.19 -0.32 1.76e-9 Neuroticism; LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04478727 chr12:58166393 METTL1;FAM119B 0.45 6.05 0.31 3.84e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4332037 0.538 rs6951956 chr7:1934131 C/T cg11693508 chr17:37793320 STARD3 0.5 6.96 0.36 1.86e-11 Bipolar disorder; LUSC cis rs10771431 0.817 rs10843149 chr12:9362067 G/A cg00504896 chr12:9437009 LOC642846 -0.39 -5.8 -0.3 1.58e-8 Breast size; LUSC cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.09 0.58 6.77e-32 Platelet count; LUSC cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg17366294 chr4:99064904 C4orf37 0.5 8.7 0.43 1.54e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg17294928 chr15:75287854 SCAMP5 0.41 5.88 0.31 1e-8 Breast cancer; LUSC trans rs679582 1.000 rs632057 chr6:139834012 G/T cg15811753 chr2:65454775 ACTR2 -0.35 -6.02 -0.31 4.64e-9 Blood trace element (Se levels); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04713951 chr22:38966166 DMC1 -0.42 -6.36 -0.33 6.69e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10489525 0.599 rs17033129 chr1:115611539 C/T cg17147537 chr1:115611705 TSPAN2 0.3 5.81 0.3 1.42e-8 Autism; LUSC trans rs11723530 0.513 rs6816345 chr4:170813779 T/C cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.28 -0.32 1.03e-9 Myopia (pathological); LUSC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg13319975 chr6:146136371 FBXO30 0.45 7.0 0.36 1.39e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg17420585 chr12:42539391 GXYLT1 -0.36 -7.04 -0.36 1.11e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs13315871 1.000 rs28489489 chr3:58443755 C/A cg12435725 chr3:58293450 RPP14 -0.7 -6.93 -0.35 2.21e-11 Cholesterol, total; LUSC trans rs11252926 0.624 rs7085214 chr10:468133 A/G cg00953403 chr17:74099816 EXOC7 0.42 6.23 0.32 1.39e-9 Psychosis in Alzheimer's disease; LUSC cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -8.93 -0.44 2.87e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10193935 1.000 rs10190326 chr2:42388262 A/C cg27598129 chr2:42591480 NA 0.57 7.97 0.4 2.56e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg09365446 chr1:150670422 GOLPH3L 0.47 6.88 0.35 3.03e-11 Melanoma; LUSC cis rs6752107 1.000 rs6431654 chr2:234161769 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.69 11.78 0.54 5.18e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7923609 0.756 rs12768534 chr10:65340897 A/G cg01631684 chr10:65280961 REEP3 -0.39 -5.88 -0.31 9.87e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs113835537 0.597 rs4576 chr11:66331000 A/G cg24851651 chr11:66362959 CCS 0.56 8.62 0.43 2.68e-16 Airway imaging phenotypes; LUSC cis rs9300255 0.510 rs1790109 chr12:123637752 C/G cg05973401 chr12:123451056 ABCB9 0.54 6.64 0.34 1.24e-10 Neutrophil percentage of white cells; LUSC cis rs713587 0.875 rs6746013 chr2:25143649 C/G cg04586622 chr2:25135609 ADCY3 0.4 8.17 0.41 6.64e-15 Body mass index in non-asthmatics; LUSC cis rs3741151 1.000 rs78433080 chr11:73067565 G/A cg17517138 chr11:73019481 ARHGEF17 1.09 9.0 0.44 1.69e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9549367 0.789 rs2025247 chr13:113882564 C/G cg18105134 chr13:113819100 PROZ -0.67 -9.41 -0.46 8.43e-19 Platelet distribution width; LUSC cis rs7119038 0.731 rs10892283 chr11:118636980 A/G cg19308663 chr11:118741387 NA 0.36 6.17 0.32 1.96e-9 Sjögren's syndrome; LUSC cis rs9788721 0.902 rs114205691 chr15:78901113 C/T cg06917634 chr15:78832804 PSMA4 -0.44 -5.91 -0.31 8.24e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs72674100 1.000 rs2865759 chr4:97992416 C/T cg16405019 chr1:18959625 PAX7 -0.62 -6.98 -0.36 1.56e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7264396 0.690 rs17093156 chr20:34438583 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.65 -0.43 2.19e-16 Total cholesterol levels; LUSC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.69 0.5 3.96e-23 Schizophrenia; LUSC cis rs2204008 0.630 rs1283300 chr12:38150227 C/T cg13010199 chr12:38710504 ALG10B -0.51 -7.68 -0.39 1.78e-13 Bladder cancer; LUSC trans rs8073060 0.544 rs225274 chr17:33971221 C/T cg19694781 chr19:47549865 TMEM160 1.08 17.05 0.68 2.37e-47 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg04733989 chr22:42467013 NAGA -0.62 -9.75 -0.47 6.31e-20 Schizophrenia; LUSC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg03929089 chr4:120376271 NA -0.94 -16.11 -0.66 1.31e-43 Height; LUSC cis rs77106637 0.932 rs7109082 chr11:72707441 A/C cg03713592 chr11:72463424 ARAP1 0.77 9.1 0.45 8.64e-18 Type 2 diabetes; LUSC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg04352962 chr1:209979756 IRF6 0.49 6.54 0.34 2.31e-10 Cleft lip with or without cleft palate; LUSC cis rs7568458 0.870 rs6757263 chr2:85803542 A/G cg23752985 chr2:85803571 VAMP8 0.36 8.03 0.4 1.67e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg05347473 chr6:146136440 FBXO30 0.56 9.67 0.47 1.14e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.45 -7.42 -0.38 9.95e-13 Electroencephalogram traits; LUSC cis rs1577917 0.696 rs10806334 chr6:86439329 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -9.55 -0.46 2.82e-19 Response to antipsychotic treatment; LUSC cis rs6427508 1 rs6427508 chr1:160238857 T/C cg02974968 chr1:160236444 NA -0.44 -7.9 -0.4 4.14e-14 Breast size; LUSC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg20135002 chr11:47629003 NA -0.51 -7.98 -0.4 2.41e-14 Subjective well-being; LUSC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg25251562 chr2:3704773 ALLC -0.48 -7.39 -0.38 1.15e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg19318889 chr4:1322082 MAEA 0.45 7.5 0.38 5.79e-13 Obesity-related traits; LUSC cis rs3849570 0.961 rs7620240 chr3:81762787 G/T cg07356753 chr3:81810745 GBE1 -0.7 -11.21 -0.52 5.48e-25 Waist circumference;Body mass index; LUSC cis rs208520 1.000 rs208521 chr6:66953625 C/T cg07460842 chr6:66804631 NA -0.96 -12.45 -0.56 1.77e-29 Exhaled nitric oxide output; LUSC trans rs2243480 0.803 rs35268390 chr7:65416536 C/G cg10756647 chr7:56101905 PSPH 0.87 8.46 0.42 8.32e-16 Diabetic kidney disease; LUSC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg22484793 chr3:52261325 TLR9 -0.28 -6.17 -0.32 2.03e-9 Bipolar disorder; LUSC cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg12463550 chr7:65579703 CRCP 0.45 6.76 0.35 6.2e-11 Aortic root size; LUSC cis rs250677 0.522 rs6580589 chr5:148360335 C/G cg18129178 chr5:148520854 ABLIM3 0.52 7.36 0.37 1.41e-12 Breast cancer; LUSC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg08645402 chr16:4508243 NA 0.47 7.2 0.37 4.02e-12 Schizophrenia; LUSC cis rs2120019 0.567 rs12385940 chr15:75168162 C/T cg09165964 chr15:75287851 SCAMP5 -0.96 -11.67 -0.54 1.21e-26 Blood trace element (Zn levels); LUSC cis rs10992471 0.528 rs1924244 chr9:95224952 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.25 -0.32 1.28e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs61869271 0.871 rs6585309 chr10:116730337 A/G cg23260525 chr10:116636907 FAM160B1 -0.31 -6.02 -0.31 4.55e-9 Tonsillectomy; LUSC cis rs17824933 0.943 rs11230566 chr11:60780007 G/A cg16817237 chr11:60793675 NA 0.41 6.46 0.33 3.75e-10 Multiple sclerosis; LUSC trans rs75804782 0.641 rs72987321 chr2:239352765 T/G cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.11e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg18512352 chr11:47633146 NA -0.46 -9.17 -0.45 4.87e-18 Neuroticism; LUSC cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg14582100 chr15:45693742 SPATA5L1 0.59 10.53 0.5 1.44e-22 Homoarginine levels; LUSC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.24 0.45 2.9e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs8032315 0.965 rs7497304 chr15:91429176 G/T cg06330618 chr15:91428456 FES 0.29 5.92 0.31 8.18e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.93e-21 Bladder cancer; LUSC cis rs1670533 0.932 rs4690347 chr4:1057328 A/G cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg08859206 chr1:53392774 SCP2 -0.68 -13.18 -0.59 3.02e-32 Monocyte count; LUSC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs9549367 0.789 rs9549711 chr13:113900557 C/T cg18105134 chr13:113819100 PROZ -0.68 -9.6 -0.47 1.9e-19 Platelet distribution width; LUSC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg05425664 chr17:57184151 TRIM37 -0.57 -8.56 -0.42 4.21e-16 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg07092213 chr7:1199455 ZFAND2A -0.59 -9.41 -0.46 8.55e-19 Longevity;Endometriosis; LUSC cis rs9300255 0.722 rs12304248 chr12:123810425 C/T cg13010344 chr12:123464640 ARL6IP4 0.5 6.37 0.33 6.4e-10 Neutrophil percentage of white cells; LUSC trans rs17685 0.523 rs10246583 chr7:75746667 C/A cg19862616 chr7:65841803 NCRNA00174 1.11 18.84 0.72 1.94e-54 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03226245 chr19:36486125 SDHAF1 0.48 6.56 0.34 2.04e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs1478897 0.575 rs12679960 chr8:11430990 C/T cg15556689 chr8:8085844 FLJ10661 0.59 8.75 0.43 1.09e-16 Systemic lupus erythematosus; LUSC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -6.06 -0.31 3.77e-9 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.909 rs73842633 chr4:120375464 G/A cg25214090 chr10:38739885 LOC399744 0.57 8.26 0.41 3.44e-15 Corneal astigmatism; LUSC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg11366901 chr6:160182831 ACAT2 0.92 12.11 0.55 3.07e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs7927592 0.913 rs3740629 chr11:68343593 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.73 -0.3 2.24e-8 Total body bone mineral density; LUSC cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.53 -7.03 -0.36 1.15e-11 Alzheimer's disease (late onset); LUSC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg00677455 chr12:58241039 CTDSP2 0.71 11.0 0.52 3.13e-24 Multiple sclerosis; LUSC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg04369109 chr6:150039330 LATS1 -0.55 -8.09 -0.4 1.14e-14 Lung cancer; LUSC cis rs7267979 1.000 rs6050565 chr20:25347563 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.8 -0.73 2.79e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12711979 0.509 rs13005405 chr2:3826324 C/T cg17052675 chr2:3827356 NA -0.83 -19.73 -0.73 5.32e-58 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs4332037 0.950 rs10267593 chr7:1937261 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -7.08 -0.36 8.51e-12 Bipolar disorder; LUSC cis rs7084921 0.608 rs2862948 chr10:101864173 A/G cg02250046 chr10:101825185 CPN1 -0.33 -6.11 -0.32 2.82e-9 Bone mineral density; LUSC cis rs9283706 0.594 rs1428405 chr5:66327193 A/T cg11590213 chr5:66331682 MAST4 0.44 6.62 0.34 1.42e-10 Coronary artery disease; LUSC cis rs17270561 0.609 rs9358872 chr6:25727517 G/A cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.86 11.65 0.54 1.54e-26 Chronic sinus infection; LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4820539 1.000 rs916585 chr22:23469438 G/A cg14186256 chr22:23484241 RTDR1 0.95 18.06 0.7 2.27e-51 Bone mineral density; LUSC cis rs7568458 0.846 rs6547621 chr2:85774676 G/A cg02493740 chr2:85810744 VAMP5 -0.37 -6.5 -0.34 2.89e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs75804782 0.641 rs56396448 chr2:239335234 C/T cg01134436 chr17:81009848 B3GNTL1 0.65 6.24 0.32 1.3e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs28655083 0.956 rs1485792 chr16:77100439 G/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.46 -7.04 -0.36 1.12e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs57221529 0.766 rs72706608 chr5:559203 C/T cg25482853 chr8:67687455 SGK3 1.19 19.12 0.72 1.43e-55 Lung disease severity in cystic fibrosis; LUSC cis rs7618501 0.722 rs9853458 chr3:49783211 A/C cg13072238 chr3:49761600 GMPPB -0.4 -6.49 -0.33 3.1e-10 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2790893 chr1:231508976 T/G cg06096015 chr1:231504339 EGLN1 0.56 9.88 0.48 2.26e-20 Hemoglobin concentration; LUSC cis rs950776 0.518 rs11630349 chr15:78824608 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg05165339 chr4:1420672 NA 0.29 6.97 0.36 1.69e-11 Longevity; LUSC cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg00071950 chr4:10020882 SLC2A9 -0.56 -9.65 -0.47 1.37e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg22166914 chr1:53195759 ZYG11B 0.67 11.31 0.53 2.54e-25 Monocyte count; LUSC cis rs2074585 0.560 rs1973537 chr15:91062901 T/C cg10434728 chr15:90938212 IQGAP1 -0.36 -6.75 -0.35 6.69e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2274459 0.749 rs12190155 chr6:33663241 G/A cg06253072 chr6:33679850 C6orf125 0.48 5.76 0.3 1.94e-8 Obesity (extreme); LUSC cis rs62400317 0.762 rs12202704 chr6:44819614 G/T cg20913747 chr6:44695427 NA -0.49 -7.63 -0.39 2.54e-13 Total body bone mineral density; LUSC cis rs1577917 0.958 rs3857480 chr6:86535149 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg26566898 chr11:117069891 TAGLN 0.37 7.18 0.37 4.46e-12 Blood protein levels; LUSC trans rs12310956 0.510 rs10844690 chr12:33854752 C/A cg13010199 chr12:38710504 ALG10B 0.46 7.02 0.36 1.28e-11 Morning vs. evening chronotype; LUSC cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.09e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1385374 0.502 rs923077 chr12:129276708 C/A cg09035930 chr12:129282057 SLC15A4 0.65 6.81 0.35 4.67e-11 Systemic lupus erythematosus; LUSC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg18200150 chr17:30822561 MYO1D 0.45 8.87 0.44 4.43e-17 Schizophrenia; LUSC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.05 -0.4 1.5e-14 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg00990874 chr7:1149470 C7orf50 -0.58 -7.6 -0.38 3.12e-13 Bronchopulmonary dysplasia; LUSC cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg09626299 chr10:82213104 TSPAN14 -0.19 -5.73 -0.3 2.24e-8 Post bronchodilator FEV1; LUSC cis rs9296092 0.517 rs7743178 chr6:33470462 G/A cg13560919 chr6:33536144 NA -0.78 -13.33 -0.59 8.65e-33 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7617480 0.648 rs4974088 chr3:48898749 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.32 0.45 1.59e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs2227564 0.794 rs2688607 chr10:75663736 C/T cg23231163 chr10:75533350 FUT11 0.44 6.25 0.32 1.26e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6964587 0.967 rs410 chr7:91557425 C/G cg22709100 chr7:91322751 NA -0.41 -6.01 -0.31 4.95e-9 Breast cancer; LUSC trans rs1256061 0.874 rs7156924 chr14:64724834 G/T cg07874507 chr10:24503148 KIAA1217 0.34 5.97 0.31 6.07e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9486719 1.000 rs2472887 chr6:96865437 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs11758351 1.000 rs1341759 chr6:26195502 G/A cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC cis rs1832871 0.672 rs62437399 chr6:158784251 C/A cg07165851 chr6:158734300 TULP4 0.46 6.7 0.34 8.67e-11 Height; LUSC cis rs727505 1.000 rs7801661 chr7:124483222 C/T cg23710748 chr7:124431027 NA 0.42 7.7 0.39 1.51e-13 Lewy body disease; LUSC cis rs1832871 0.711 rs12525147 chr6:158683509 A/G cg07165851 chr6:158734300 TULP4 0.52 7.79 0.39 8.49e-14 Height; LUSC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg06454157 chr6:167490870 NA -0.26 -6.13 -0.32 2.42e-9 Crohn's disease; LUSC cis rs9303401 0.659 rs11079357 chr17:56902778 A/G cg25039879 chr17:56429692 SUPT4H1 0.67 8.95 0.44 2.48e-17 Cognitive test performance; LUSC trans rs7824557 0.767 rs3808513 chr8:11157460 G/T cg15556689 chr8:8085844 FLJ10661 -0.52 -8.06 -0.4 1.39e-14 Retinal vascular caliber; LUSC cis rs7474896 0.583 rs1735621 chr10:38167723 G/T cg25427524 chr10:38739819 LOC399744 0.45 5.95 0.31 6.76e-9 Obesity (extreme); LUSC cis rs12410462 0.582 rs12408978 chr1:227596235 A/T cg04117972 chr1:227635322 NA -0.69 -7.74 -0.39 1.22e-13 Major depressive disorder; LUSC cis rs4065321 0.522 rs11078930 chr17:38141955 C/T cg17467752 chr17:38218738 THRA -0.51 -7.14 -0.36 5.74e-12 White blood cell count (basophil);White blood cell count; LUSC cis rs17270561 0.609 rs9358884 chr6:25756592 A/G cg16482183 chr6:26056742 HIST1H1C 0.65 9.14 0.45 6.04e-18 Iron status biomarkers; LUSC cis rs9815354 0.857 rs73830583 chr3:41996948 C/T cg03022575 chr3:42003672 ULK4 0.85 8.86 0.44 4.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs28655083 0.509 rs664408 chr16:77104820 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 7.11 0.36 7.24e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs9944715 1.000 rs9963843 chr18:43842618 C/A cg01718231 chr17:29326311 RNF135 -0.5 -6.95 -0.36 1.97e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs2050392 0.858 rs306583 chr10:30710057 C/T cg18806716 chr10:30721971 MAP3K8 0.44 7.23 0.37 3.3e-12 Inflammatory bowel disease; LUSC trans rs17685 0.712 rs9800948 chr7:75810473 A/G cg19862616 chr7:65841803 NCRNA00174 0.89 14.61 0.62 1.04e-37 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs806795 0.605 rs809871 chr6:26256526 C/G cg13736514 chr6:26305472 NA 0.44 8.14 0.41 7.95e-15 Mosquito bite size; LUSC cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg21535247 chr6:8435926 SLC35B3 0.57 9.02 0.44 1.5e-17 Motion sickness; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.73 -12.67 -0.57 2.51e-30 Prudent dietary pattern; LUSC trans rs10421385 1.000 rs10421385 chr19:51701891 A/G cg07580831 chr2:79385573 REG3A 0.3 6.07 0.32 3.41e-9 Blood protein levels; LUSC cis rs9902453 0.933 rs7225462 chr17:28321226 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.4 0.49 4.09e-22 Coffee consumption (cups per day); LUSC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg02018176 chr4:1364513 KIAA1530 0.55 9.67 0.47 1.13e-19 Longevity; LUSC cis rs4285028 0.696 rs3915060 chr3:121712980 C/T cg20356878 chr3:121714668 ILDR1 0.5 6.87 0.35 3.06e-11 Multiple sclerosis; LUSC cis rs9388451 0.839 rs4897155 chr6:126095144 C/A cg10911889 chr6:126070802 HEY2 0.42 6.39 0.33 5.41e-10 Brugada syndrome; LUSC cis rs6840360 0.571 rs62327272 chr4:152545090 A/C cg22705602 chr4:152727874 NA -0.33 -6.64 -0.34 1.25e-10 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg18230493 chr5:56204884 C5orf35 -0.79 -12.52 -0.57 9.14e-30 Initial pursuit acceleration; LUSC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC trans rs656319 0.559 rs55683917 chr8:9976479 C/G cg06636001 chr8:8085503 FLJ10661 -0.43 -5.97 -0.31 6.17e-9 Myopia (pathological); LUSC cis rs7640424 0.784 rs68044584 chr3:107845395 A/G cg09227934 chr3:107805635 CD47 -0.43 -6.61 -0.34 1.57e-10 Body mass index; LUSC cis rs6940638 0.688 rs6456766 chr6:27019575 G/A cg12826209 chr6:26865740 GUSBL1 0.51 7.36 0.37 1.43e-12 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg09491104 chr22:46646882 C22orf40 -0.63 -7.19 -0.37 4.35e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.64 0.34 1.29e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg24562669 chr7:97807699 LMTK2 0.34 6.02 0.31 4.69e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1729951 0.575 rs835642 chr3:136703365 A/T cg21827317 chr3:136751795 NA 0.4 7.21 0.37 3.8e-12 Neuroticism; LUSC cis rs7799006 1.000 rs7810970 chr7:2276385 A/G cg12823233 chr7:2316876 SNX8 -0.33 -5.76 -0.3 1.92e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg21427119 chr20:30132790 HM13 -0.37 -5.69 -0.3 2.8e-8 Mean corpuscular hemoglobin; LUSC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg02527881 chr3:46936655 PTH1R -0.42 -7.57 -0.38 3.75e-13 Colorectal cancer; LUSC trans rs6076960 0.629 rs6054031 chr20:6233657 C/G cg17788362 chr6:86352627 SYNCRIP 0.42 6.14 0.32 2.34e-9 Smooth-surface caries; LUSC cis rs427941 0.632 rs201493 chr7:101754865 T/C cg06246474 chr7:101738831 CUX1 0.4 6.51 0.34 2.83e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs9653442 0.511 rs6739695 chr2:100859622 A/G cg22139774 chr2:100720529 AFF3 -0.38 -6.24 -0.32 1.31e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg13647721 chr17:30228624 UTP6 -0.62 -5.89 -0.31 9.27e-9 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg03676636 chr4:99064102 C4orf37 0.36 8.08 0.4 1.16e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9399135 0.933 rs9389262 chr6:135376409 G/T cg24558204 chr6:135376177 HBS1L 0.59 9.08 0.44 9.59e-18 Red blood cell count; LUSC cis rs4604732 0.631 rs10925043 chr1:247627001 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs12310956 0.532 rs11052920 chr12:33955891 T/G cg13010199 chr12:38710504 ALG10B 0.49 7.53 0.38 4.89e-13 Morning vs. evening chronotype; LUSC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg01448562 chr3:133502909 NA -0.36 -5.77 -0.3 1.76e-8 Iron status biomarkers (transferrin levels); LUSC cis rs3772130 0.962 rs7629369 chr3:121566282 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.69 9.98 0.48 1.09e-20 Cognitive performance; LUSC trans rs11098499 0.774 rs11098505 chr4:120284627 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs6545883 0.929 rs1209434 chr2:61672958 G/A cg15711740 chr2:61764176 XPO1 -0.44 -6.73 -0.35 7.36e-11 Tuberculosis; LUSC cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg26384229 chr12:38710491 ALG10B 0.89 15.26 0.64 2.9e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg04414720 chr1:150670196 GOLPH3L -0.48 -7.57 -0.38 3.74e-13 Tonsillectomy; LUSC cis rs2224391 0.534 rs2773308 chr6:5246833 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.5 -6.87 -0.35 3.16e-11 Height; LUSC cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg27129171 chr3:47204927 SETD2 -0.68 -10.37 -0.49 5.08e-22 Colorectal cancer; LUSC cis rs12210905 1.000 rs7759955 chr6:26709424 G/A cg11502198 chr6:26597334 ABT1 -0.74 -5.81 -0.3 1.5e-8 Hip circumference adjusted for BMI; LUSC cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg00071950 chr4:10020882 SLC2A9 -0.48 -7.76 -0.39 1.04e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg12564285 chr5:131593104 PDLIM4 0.46 8.12 0.41 8.78e-15 Breast cancer; LUSC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg02569458 chr12:86230093 RASSF9 0.48 7.65 0.39 2.21e-13 Major depressive disorder; LUSC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11644478 chr21:40555479 PSMG1 -0.77 -13.67 -0.6 4.35e-34 Cognitive function; LUSC cis rs9815354 1.000 rs9856633 chr3:42013850 C/T cg03022575 chr3:42003672 ULK4 0.52 5.97 0.31 5.91e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg02117656 chr17:79614917 TSPAN10 -0.31 -5.69 -0.3 2.71e-8 Eye color traits; LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg25072359 chr17:41440525 NA -0.63 -8.87 -0.44 4.51e-17 Menopause (age at onset); LUSC trans rs8002861 0.967 rs2325071 chr13:44476793 T/C cg17145862 chr1:211918768 LPGAT1 0.23 6.01 0.31 4.76e-9 Leprosy; LUSC cis rs10911232 0.507 rs4652763 chr1:182994084 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg00631329 chr6:26305371 NA -0.45 -8.86 -0.44 4.68e-17 Educational attainment; LUSC cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg22907277 chr7:1156413 C7orf50 0.53 6.71 0.34 8.32e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg07636037 chr3:49044803 WDR6 1.02 18.58 0.71 1.93e-53 Parkinson's disease; LUSC cis rs9616064 0.886 rs11703960 chr22:46986423 A/T cg25730555 chr22:47059586 GRAMD4 0.45 6.51 0.34 2.7e-10 Urate levels in obese individuals; LUSC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg17264618 chr3:40429014 ENTPD3 0.34 7.27 0.37 2.63e-12 Renal cell carcinoma; LUSC cis rs1801251 1.000 rs71421663 chr2:233619131 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.69 0.34 9.35e-11 Coronary artery disease; LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg03354898 chr7:1950403 MAD1L1 -0.42 -8.54 -0.42 4.86e-16 Bipolar disorder and schizophrenia; LUSC cis rs35883536 0.626 rs7536054 chr1:101047849 A/G cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC trans rs2262909 0.962 rs422344 chr19:22230956 C/G cg05197062 chr11:11642011 GALNTL4 0.54 7.64 0.39 2.3e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg06634786 chr22:41940651 POLR3H -0.6 -6.77 -0.35 5.66e-11 Vitiligo; LUSC cis rs3008870 0.920 rs2755253 chr1:67470843 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.83 13.32 0.59 9.24e-33 Lymphocyte percentage of white cells; LUSC cis rs713587 1.000 rs2384054 chr2:25156773 T/C cg01884057 chr2:25150051 NA 0.49 11.61 0.54 2.1e-26 Body mass index in non-asthmatics; LUSC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg12310025 chr6:25882481 NA -0.62 -10.51 -0.5 1.6400000000000001e-22 Blood metabolite levels; LUSC cis rs11597390 0.867 rs11596837 chr10:101850079 C/A cg11888571 chr10:102027403 CWF19L1 -0.43 -5.97 -0.31 6.17e-9 Liver enzyme levels; LUSC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.1 0.32 2.88e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg13010199 chr12:38710504 ALG10B 0.69 11.46 0.53 7.01e-26 Heart rate; LUSC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg02428538 chr16:24856791 SLC5A11 -0.52 -5.92 -0.31 8.01e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.612 rs6830172 chr4:99093947 G/A cg17366294 chr4:99064904 C4orf37 0.53 9.15 0.45 5.71e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.590 rs763914 chr10:104841587 T/C cg05855489 chr10:104503620 C10orf26 0.53 7.96 0.4 2.77e-14 Arsenic metabolism; LUSC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg18904891 chr8:8559673 CLDN23 0.4 5.93 0.31 7.46e-9 Mood instability; LUSC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg03452623 chr4:187889614 NA -0.88 -18.62 -0.71 1.43e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs7640424 0.819 rs179046 chr3:107840773 A/C cg09227934 chr3:107805635 CD47 -0.39 -6.15 -0.32 2.16e-9 Body mass index; LUSC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg09021430 chr5:549028 NA -0.54 -7.07 -0.36 8.97e-12 Lung disease severity in cystic fibrosis; LUSC cis rs7524258 0.868 rs916393 chr1:7272250 T/C cg07173049 chr1:7289937 CAMTA1 0.33 6.82 0.35 4.29e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg20404643 chr11:1492543 HCCA2 0.46 6.0 0.31 5.05e-9 Neuroticism; LUSC cis rs7119 0.651 rs12917431 chr15:77850184 C/G cg27398640 chr15:77910606 LINGO1 -0.34 -7.0 -0.36 1.37e-11 Type 2 diabetes; LUSC cis rs6728642 0.908 rs10203833 chr2:98017363 G/A cg26665480 chr2:98280029 ACTR1B -0.67 -5.89 -0.31 9.54e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.63 -5.9 -0.31 8.74e-9 Cerebrospinal P-tau181p levels; LUSC cis rs1507153 0.775 rs12194701 chr6:79372837 G/A cg05283184 chr6:79620031 NA -0.42 -7.21 -0.37 3.75e-12 Sjögren's syndrome; LUSC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg18681998 chr4:17616180 MED28 0.77 13.73 0.6 2.53e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs868036 1.000 rs4776975 chr15:68102220 G/C cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg13319975 chr6:146136371 FBXO30 0.5 7.6 0.38 2.95e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg12432903 chr7:1882776 MAD1L1 -0.51 -8.77 -0.43 9.09e-17 Bipolar disorder and schizophrenia; LUSC cis rs7267979 0.932 rs433352 chr20:25467992 C/T cg08601574 chr20:25228251 PYGB -0.39 -5.75 -0.3 2.03e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg07701084 chr6:150067640 NUP43 0.52 7.78 0.39 8.84e-14 Lung cancer; LUSC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg17554472 chr22:41940697 POLR3H -0.47 -5.82 -0.3 1.35e-8 Vitiligo; LUSC cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg13852791 chr20:30311386 BCL2L1 0.83 10.25 0.49 1.31e-21 Mean corpuscular hemoglobin; LUSC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg19812747 chr11:111475976 SIK2 -0.53 -7.7 -0.39 1.59e-13 Primary sclerosing cholangitis; LUSC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg03806693 chr22:41940476 POLR3H -0.88 -13.36 -0.59 6.63e-33 Vitiligo; LUSC cis rs2303282 0.716 rs8056687 chr16:56468561 C/T cg00500540 chr16:56394104 NA -0.43 -7.35 -0.37 1.52e-12 Breast cancer; LUSC cis rs11018904 0.861 rs12787117 chr11:89943681 A/G cg26138821 chr11:89956704 CHORDC1 -0.58 -6.64 -0.34 1.3100000000000001e-10 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg13939156 chr17:80058883 NA -0.33 -6.46 -0.33 3.74e-10 Life satisfaction; LUSC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg15556689 chr8:8085844 FLJ10661 0.66 10.81 0.51 1.49e-23 Mood instability; LUSC cis rs1507153 0.549 rs236862 chr6:79334972 T/C cg05283184 chr6:79620031 NA 0.38 7.1 0.36 7.78e-12 Sjögren's syndrome; LUSC cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.83 -0.51 1.24e-23 Alzheimer's disease (late onset); LUSC cis rs8014204 0.604 rs7156590 chr14:75388183 C/T cg03030879 chr14:75389066 RPS6KL1 -0.36 -6.92 -0.35 2.31e-11 Caffeine consumption; LUSC cis rs6840360 0.571 rs10007653 chr4:152524055 A/G cg22705602 chr4:152727874 NA -0.29 -5.77 -0.3 1.83e-8 Intelligence (multi-trait analysis); LUSC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg14583973 chr4:3374767 RGS12 0.36 7.94 0.4 3.14e-14 Serum sulfate level; LUSC cis rs734999 0.566 rs10797435 chr1:2534801 G/C cg18854424 chr1:2615690 NA 0.5 9.97 0.48 1.12e-20 Ulcerative colitis; LUSC cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.63 0.85 1.69e-95 Chronic sinus infection; LUSC cis rs73206853 0.925 rs12297709 chr12:110901758 A/G cg12870014 chr12:110450643 ANKRD13A 0.5 5.9 0.31 9.03e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.2 0.32 1.62e-9 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19869610 chr19:45996498 RTN2 0.41 6.21 0.32 1.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.18 -0.41 6.14e-15 Axial length; LUSC trans rs9329221 0.510 rs4841282 chr8:9975604 C/A cg21775007 chr8:11205619 TDH 0.44 6.26 0.32 1.17e-9 Neuroticism; LUSC cis rs3126085 0.877 rs7535536 chr1:152193544 A/G cg26876637 chr1:152193138 HRNR 0.43 6.24 0.32 1.34e-9 Atopic dermatitis; LUSC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12136530 0.774 rs10158117 chr1:19766747 G/C cg01832549 chr1:19774989 CAPZB -0.31 -5.73 -0.3 2.28e-8 Lead levels in blood; LUSC cis rs806215 0.756 rs806221 chr7:127243426 G/A cg25922125 chr7:127225783 GCC1 0.52 6.69 0.34 9.51e-11 Type 2 diabetes; LUSC cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg27446573 chr6:127587934 RNF146 0.69 10.59 0.5 8.81e-23 Breast cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg27193377 chr16:75498489 TMEM170A 0.69 5.96 0.31 6.57e-9 Cognitive performance; LUSC cis rs7149337 0.933 rs28705789 chr14:51713508 C/T cg23942311 chr14:51606299 NA 0.47 10.61 0.5 7.21e-23 Cancer; LUSC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg18404041 chr3:52824283 ITIH1 -0.34 -6.16 -0.32 2.1e-9 Electroencephalogram traits; LUSC cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -15.16 -0.64 7.12e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg09826364 chr7:158789723 NA -0.37 -5.72 -0.3 2.4e-8 Facial morphology (factor 20); LUSC cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg12573674 chr2:1569213 NA -0.55 -6.08 -0.32 3.38e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.55 8.33 0.41 2.16e-15 Total body bone mineral density; LUSC cis rs926392 0.572 rs6129158 chr20:37673967 A/G cg16355469 chr20:37678765 NA 0.54 7.42 0.38 9.52e-13 Dialysis-related mortality; LUSC cis rs7267979 1.000 rs6050599 chr20:25400240 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg21535247 chr6:8435926 SLC35B3 -0.58 -8.64 -0.43 2.31e-16 Motion sickness; LUSC cis rs4595586 0.545 rs969468 chr12:39367278 A/C cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs28374715 0.783 rs11635269 chr15:41570710 A/G cg18705301 chr15:41695430 NDUFAF1 -0.99 -20.52 -0.75 3.99e-61 Ulcerative colitis; LUSC cis rs79387448 0.745 rs74560841 chr2:103149210 G/A cg09003973 chr2:102972529 NA 0.98 9.33 0.45 1.54e-18 Gut microbiota (bacterial taxa); LUSC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC trans rs7613875 0.641 rs6446194 chr3:50067298 T/A cg21659725 chr3:3221576 CRBN -0.52 -8.33 -0.41 2.05e-15 Body mass index; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg00945038 chr17:61921165 SMARCD2 -0.42 -7.18 -0.37 4.59e-12 Prudent dietary pattern; LUSC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg22166914 chr1:53195759 ZYG11B -0.55 -8.77 -0.43 9.2e-17 Monocyte count; LUSC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg00825309 chr19:58991885 ZNF446 -0.5 -7.13 -0.36 6.4e-12 Uric acid clearance; LUSC cis rs1784581 0.588 rs10945792 chr6:162423484 C/T cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.05e-20 Itch intensity from mosquito bite; LUSC trans rs9393777 0.841 rs67092078 chr6:27054772 G/A cg01620082 chr3:125678407 NA -0.73 -6.26 -0.32 1.18e-9 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs7071271 chr10:102264824 G/A cg23241863 chr10:102295624 HIF1AN 0.5 5.98 0.31 5.63e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg14552801 chr7:65878734 NA 0.37 5.68 0.3 2.98e-8 Aortic root size; LUSC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.95 12.82 0.57 6.98e-31 Smoking behavior; LUSC cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg23711669 chr6:146136114 FBXO30 0.92 17.57 0.69 2.14e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg22906224 chr7:99728672 NA 0.47 6.51 0.34 2.82e-10 Coronary artery disease; LUSC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg11812906 chr14:75593930 NEK9 0.67 11.71 0.54 8.78e-27 Height; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg07157834 chr1:205819609 PM20D1 0.85 15.31 0.64 1.86e-40 Menarche (age at onset); LUSC trans rs7829975 0.501 rs2980769 chr8:8320291 G/A cg21775007 chr8:11205619 TDH 0.42 6.13 0.32 2.41e-9 Mood instability; LUSC cis rs6545883 0.868 rs2518932 chr2:61801277 T/A cg15711740 chr2:61764176 XPO1 -0.46 -7.28 -0.37 2.35e-12 Tuberculosis; LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg16606324 chr3:10149918 C3orf24 0.55 7.4 0.38 1.11e-12 Alzheimer's disease; LUSC cis rs847577 0.569 rs12674083 chr7:97696334 C/T cg24562669 chr7:97807699 LMTK2 0.47 8.38 0.42 1.52e-15 Breast cancer; LUSC cis rs7843479 1.000 rs13276082 chr8:21823184 A/G cg17168535 chr8:21777572 XPO7 0.66 10.09 0.48 4.62e-21 Mean corpuscular volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22718729 chr4:41216034 APBB2 -0.39 -5.98 -0.31 5.85e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg00933542 chr6:150070202 PCMT1 0.33 6.7 0.34 8.84e-11 Lung cancer; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.79 -0.39 8.61e-14 Lymphocyte counts; LUSC cis rs9457247 0.602 rs2157388 chr6:167481912 G/A cg07741184 chr6:167504864 NA 0.49 8.48 0.42 7.31e-16 Crohn's disease; LUSC cis rs10740039 0.768 rs920646 chr10:62463525 C/T cg18175470 chr10:62150864 ANK3 -0.44 -6.62 -0.34 1.44e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7296418 0.663 rs4553407 chr12:123750748 G/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.11 -0.41 9.76e-15 Platelet count; LUSC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.69 -10.93 -0.51 5.49e-24 Menarche (age at onset); LUSC trans rs1508086 0.935 rs4737447 chr8:57812235 A/G cg01310875 chr8:27938995 C8orf80 0.28 5.95 0.31 6.71e-9 Hand grip strength; LUSC cis rs55910451 0.520 rs11596435 chr10:5841222 C/T cg11519256 chr10:5708881 ASB13 -0.48 -6.18 -0.32 1.85e-9 Breast cancer; LUSC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg04362960 chr10:104952993 NT5C2 0.56 7.98 0.4 2.35e-14 Arsenic metabolism; LUSC cis rs3740713 0.669 rs34740438 chr11:18415330 C/A cg07915343 chr11:18477680 LDHAL6A -0.46 -5.78 -0.3 1.68e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2479724 0.846 rs1536702 chr6:41869950 T/A cg17623882 chr6:41773611 USP49 -0.59 -10.11 -0.48 3.94e-21 Menarche (age at onset); LUSC cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg01884057 chr2:25150051 NA 0.48 11.45 0.53 8.06e-26 Body mass index; LUSC cis rs6121246 0.609 rs6060983 chr20:30420924 T/C cg21427119 chr20:30132790 HM13 -0.35 -5.73 -0.3 2.24e-8 Mean corpuscular hemoglobin; LUSC cis rs34779708 0.966 rs34776628 chr10:35426324 G/A cg04310649 chr10:35416472 CREM -0.42 -6.59 -0.34 1.74e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs611744 0.573 rs1457210 chr8:109261562 A/G cg21045802 chr8:109455806 TTC35 -0.4 -6.34 -0.33 7.59e-10 Dupuytren's disease; LUSC cis rs9811920 0.666 rs793456 chr3:99525631 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -7.33 -0.37 1.8e-12 Axial length; LUSC cis rs4698790 1.000 rs4698790 chr4:110727560 A/C cg07850274 chr4:110748770 RRH 0.39 6.18 0.32 1.92e-9 Fasting insulin (dietary factor interaction);Homeostasis model assessment of insulin resistance (dietary factor interaction); LUSC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.65 0.3 3.49e-8 Life satisfaction; LUSC trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg03929089 chr4:120376271 NA 0.78 10.05 0.48 6.16e-21 Coronary artery disease; LUSC cis rs7769051 1.000 rs73554431 chr6:133129922 T/G cg22852734 chr6:133119734 C6orf192 1.14 13.45 0.59 2.94e-33 Type 2 diabetes nephropathy; LUSC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg06212747 chr3:49208901 KLHDC8B 0.44 5.98 0.31 5.79e-9 Parkinson's disease; LUSC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg23711669 chr6:146136114 FBXO30 0.7 10.69 0.5 3.89e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg10253484 chr15:75165896 SCAMP2 -0.46 -6.64 -0.34 1.24e-10 Breast cancer; LUSC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg00701064 chr4:6280414 WFS1 0.59 14.6 0.62 1.11e-37 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4792901 0.765 rs2127224 chr17:41569025 C/T cg22562494 chr17:41607896 ETV4 -0.35 -6.56 -0.34 2.11e-10 Dupuytren's disease; LUSC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg24531977 chr5:56204891 C5orf35 -0.72 -10.23 -0.49 1.55e-21 Coronary artery disease; LUSC cis rs59104589 0.617 rs61615527 chr2:242342768 T/A cg14842376 chr2:242211374 HDLBP 0.54 6.33 0.33 7.68e-10 Fibrinogen levels; LUSC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.87 -0.31 1.07e-8 Tonsillectomy; LUSC cis rs35264875 0.950 rs72928659 chr11:68852358 C/T cg02660097 chr11:68866761 NA 0.43 6.07 0.32 3.44e-9 Blond vs. brown hair color; LUSC cis rs981844 0.754 rs897608 chr4:154754960 C/T cg14289246 chr4:154710475 SFRP2 0.45 5.94 0.31 7.22e-9 Response to statins (LDL cholesterol change); LUSC cis rs9527 0.590 rs6584537 chr10:104778267 C/G cg04362960 chr10:104952993 NT5C2 0.62 9.83 0.47 3.35e-20 Arsenic metabolism; LUSC cis rs7267979 1.000 rs4815408 chr20:25346678 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.75 -0.73 4.73e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2439831 0.850 rs3742982 chr15:44176681 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.97 0.36 1.71e-11 Lung cancer in ever smokers; LUSC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg17366294 chr4:99064904 C4orf37 0.55 9.66 0.47 1.25e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7917772 0.604 rs4917977 chr10:104363119 C/T cg05855489 chr10:104503620 C10orf26 -0.48 -7.41 -0.38 1.04e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg24675056 chr1:15929824 NA 0.49 8.45 0.42 8.94e-16 Systolic blood pressure; LUSC cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg01849466 chr14:104193079 ZFYVE21 -0.61 -9.96 -0.48 1.23e-20 Schizophrenia; LUSC cis rs9309711 0.621 rs11127428 chr2:3471146 T/C cg15506890 chr2:3487001 NA -0.53 -8.21 -0.41 4.93e-15 Neurofibrillary tangles; LUSC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg00450029 chr8:599525 NA 0.56 5.73 0.3 2.26e-8 IgG glycosylation; LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg07212818 chr11:638076 DRD4 -0.38 -6.51 -0.34 2.79e-10 Systemic lupus erythematosus; LUSC cis rs4969178 1.000 rs4969178 chr17:76388202 C/T cg20026190 chr17:76395443 PGS1 -0.4 -7.1 -0.36 7.74e-12 HDL cholesterol levels; LUSC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg04455712 chr21:45112962 RRP1B 0.43 8.18 0.41 5.82e-15 Mean corpuscular volume; LUSC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.49e-11 Schizophrenia; LUSC cis rs4654899 0.897 rs7515308 chr1:21085653 G/C cg01072550 chr1:21505969 NA -0.47 -7.06 -0.36 9.91e-12 Superior frontal gyrus grey matter volume; LUSC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg12463550 chr7:65579703 CRCP -0.52 -7.54 -0.38 4.52e-13 Aortic root size; LUSC cis rs7917772 0.560 rs11595170 chr10:104339851 T/C cg22532475 chr10:104410764 TRIM8 0.26 6.14 0.32 2.37e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2227564 0.729 rs2688611 chr10:75653372 G/T cg23231163 chr10:75533350 FUT11 -0.45 -6.29 -0.33 9.68e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs17092148 1.000 rs6058112 chr20:33322006 G/C cg16810054 chr20:33298113 TP53INP2 -0.41 -6.24 -0.32 1.36e-9 Neuroticism; LUSC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg14552801 chr7:65878734 NA -0.46 -6.61 -0.34 1.5e-10 Aortic root size; LUSC trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg15704280 chr7:45808275 SEPT13 -0.92 -14.23 -0.61 3.04e-36 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07165811 chr19:3360732 NFIC 0.39 5.99 0.31 5.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11645898 0.935 rs72787091 chr16:72190184 C/T cg14768367 chr16:72042858 DHODH -0.67 -7.32 -0.37 1.82e-12 Blood protein levels; LUSC cis rs5769707 0.521 rs6009805 chr22:50058715 T/C cg10356904 chr22:49881777 NA -0.3 -5.94 -0.31 7.14e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg08213375 chr14:104286397 PPP1R13B 0.52 10.24 0.49 1.38e-21 Schizophrenia; LUSC trans rs11098499 0.863 rs3775858 chr4:120486028 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.75e-10 Corneal astigmatism; LUSC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.49 -0.73 4.84e-57 Height; LUSC trans rs6076960 0.684 rs3852947 chr20:6255341 A/G cg21095983 chr6:86352623 SYNCRIP 0.51 8.07 0.4 1.31e-14 Smooth-surface caries; LUSC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg01283332 chr5:1856932 NA -0.34 -6.38 -0.33 6.02e-10 Cardiovascular disease risk factors; LUSC cis rs6740322 0.895 rs6711966 chr2:43561989 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.43 -5.93 -0.31 7.56e-9 Coronary artery disease; LUSC cis rs244731 0.959 rs10037110 chr5:176658066 A/T cg06060754 chr5:176797920 RGS14 -0.62 -8.75 -0.43 1.09e-16 Urate levels in lean individuals; LUSC cis rs10392 0.543 rs748063 chr20:37548730 A/G cg27552599 chr20:37590471 DHX35 0.45 7.25 0.37 2.95e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs9549367 0.789 rs6577035 chr13:113879997 G/A cg00898013 chr13:113819073 PROZ -0.56 -8.06 -0.4 1.36e-14 Platelet distribution width; LUSC cis rs73198271 0.740 rs10103163 chr8:8650675 T/C cg01851573 chr8:8652454 MFHAS1 0.52 8.44 0.42 9.81e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11018904 0.906 rs36177012 chr11:89933319 T/C cg26834418 chr11:89957033 CHORDC1 -0.51 -6.13 -0.32 2.53e-9 Intelligence (multi-trait analysis); LUSC cis rs950027 0.620 rs1346267 chr15:45690989 A/G cg14582100 chr15:45693742 SPATA5L1 0.45 8.4 0.42 1.29e-15 Response to fenofibrate (adiponectin levels); LUSC trans rs6600671 1.000 rs10794671 chr1:121168242 A/C cg00646200 chr1:148855367 NA 0.43 6.7 0.34 8.89e-11 Hip geometry; LUSC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg23711669 chr6:146136114 FBXO30 -0.94 -17.99 -0.7 4.38e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg15448220 chr1:150897856 SETDB1 0.41 6.18 0.32 1.84e-9 Melanoma; LUSC cis rs17094222 0.504 rs12267029 chr10:102458677 C/A cg04918978 chr10:102441148 NA -0.39 -5.65 -0.3 3.51e-8 Body mass index;BMI (adjusted for smoking behaviour);Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg10978503 chr1:24200527 CNR2 0.52 13.01 0.58 1.41e-31 Immature fraction of reticulocytes; LUSC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg23791538 chr6:167370224 RNASET2 -0.41 -6.54 -0.34 2.25e-10 Crohn's disease; LUSC trans rs2243480 0.901 rs35256305 chr7:65306405 T/C cg10756647 chr7:56101905 PSPH 0.87 8.43 0.42 1.06e-15 Diabetic kidney disease; LUSC cis rs10751667 0.666 rs7950967 chr11:955638 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.07e-10 Alzheimer's disease (late onset); LUSC cis rs7614311 0.636 rs73117047 chr3:63910779 G/A cg22134162 chr3:63841271 THOC7 -0.49 -6.1 -0.32 3.02e-9 Lung function (FVC);Lung function (FEV1); LUSC trans rs80093141 0.575 rs4899111 chr14:39356991 G/A cg08262584 chr8:54154426 OPRK1 0.43 5.99 0.31 5.42e-9 Common carotid intima-media thickness in HIV infection; LUSC cis rs7107174 0.688 rs869202 chr11:78127914 A/G cg27205649 chr11:78285834 NARS2 -0.51 -5.87 -0.31 1.05e-8 Testicular germ cell tumor; LUSC cis rs151349 1.000 rs108727 chr20:57584890 C/T cg23907860 chr20:57583709 CTSZ 0.48 8.01 0.4 1.92e-14 Platelet distribution width; LUSC cis rs2979489 0.841 rs2015311 chr8:30306989 A/G cg26383811 chr8:30366931 RBPMS 0.48 7.6 0.38 3.05e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs6598955 0.616 rs11247890 chr1:26590182 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC trans rs61931739 0.500 rs4436630 chr12:34394200 C/T cg13010199 chr12:38710504 ALG10B 0.58 9.23 0.45 3.24e-18 Morning vs. evening chronotype; LUSC cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg08999081 chr20:33150536 PIGU 0.52 10.42 0.5 3.46e-22 Glomerular filtration rate (creatinine); LUSC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg18904891 chr8:8559673 CLDN23 0.55 7.53 0.38 4.84e-13 Obesity-related traits; LUSC trans rs3857536 0.813 rs62415859 chr6:66934278 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC trans rs9341835 0.518 rs6924479 chr6:64173940 A/G cg19533977 chr17:57719682 CLTC -0.32 -5.95 -0.31 6.82e-9 Schizophrenia; LUSC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs1018836 0.923 rs13267989 chr8:91581648 C/T cg16814680 chr8:91681699 NA -0.74 -12.13 -0.55 2.53e-28 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg06618935 chr21:46677482 NA -0.38 -7.57 -0.38 3.79e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2224391 1.000 rs13191012 chr6:5261292 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.74 -0.35 7.14e-11 Height; LUSC cis rs9303401 0.659 rs714959 chr17:56628601 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.83 13.31 0.59 9.7e-33 Cognitive test performance; LUSC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.2 0.41 5.41e-15 Electroencephalogram traits; LUSC cis rs7937890 0.900 rs7118682 chr11:14274550 T/G cg02886208 chr11:14281011 SPON1 0.32 5.84 0.3 1.26e-8 Mitochondrial DNA levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19877921 chr17:61904685 PSMC5;FTSJ3 -0.51 -6.47 -0.33 3.44e-10 Bipolar disorder and schizophrenia; LUSC cis rs5758659 0.657 rs5758587 chr22:42517636 C/G cg00645731 chr22:42541494 CYP2D7P1 0.28 5.66 0.3 3.33e-8 Cognitive function; LUSC cis rs9911578 0.835 rs10853006 chr17:56489076 G/A cg05425664 chr17:57184151 TRIM37 0.55 8.49 0.42 7.03e-16 Intelligence (multi-trait analysis); LUSC cis rs4900538 0.855 rs72698597 chr14:102868633 C/T cg18135206 chr14:102964638 TECPR2 -1.0 -19.2 -0.72 7.08e-56 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs13006833 0.739 rs291472 chr2:191190605 A/G cg21644426 chr2:191273491 MFSD6 0.44 6.28 0.32 1.05e-9 Urinary metabolites; LUSC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs7647973 0.588 rs4855848 chr3:49653457 C/T cg13072238 chr3:49761600 GMPPB -0.69 -9.06 -0.44 1.08e-17 Menarche (age at onset); LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg15790184 chr11:494944 RNH1 0.52 6.09 0.32 3.1e-9 Body mass index; LUSC trans rs7746199 0.736 rs13193542 chr6:27702425 G/T cg06606381 chr12:133084897 FBRSL1 -0.94 -8.79 -0.43 8.32e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs2078087 0.831 rs12404011 chr1:183247022 G/C cg13843938 chr1:183241246 NMNAT2 0.47 6.14 0.32 2.4e-9 Obesity-related traits; LUSC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg22532475 chr10:104410764 TRIM8 -0.39 -8.37 -0.42 1.65e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg25072359 chr17:41440525 NA 0.68 9.5 0.46 4.34e-19 Menopause (age at onset); LUSC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg10523679 chr1:76189770 ACADM 0.85 11.26 0.52 3.77e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18404041 chr3:52824283 ITIH1 -0.54 -10.39 -0.49 4.23e-22 Bipolar disorder; LUSC cis rs4631830 0.720 rs4935573 chr10:51504385 A/G cg10326726 chr10:51549505 MSMB 0.35 6.09 0.32 3.14e-9 Prostate-specific antigen levels; LUSC cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg17173187 chr15:85201210 NMB -0.31 -6.33 -0.33 8.05e-10 P wave terminal force; LUSC cis rs2147959 1.000 rs2147959 chr1:228644232 A/T cg18477163 chr1:228402036 OBSCN -0.44 -6.0 -0.31 5.14e-9 Adult asthma; LUSC cis rs868036 0.958 rs3784709 chr15:68072275 C/T cg08079166 chr15:68083412 MAP2K5 0.38 7.92 0.4 3.48e-14 Restless legs syndrome; LUSC cis rs9811920 0.603 rs2638948 chr3:99501539 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -7.36 -0.37 1.43e-12 Axial length; LUSC cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg05340658 chr4:99064831 C4orf37 0.69 11.89 0.55 2e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.4 -0.33 5.3e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs12893668 0.703 rs35498576 chr14:104025893 T/C cg04998671 chr14:104000505 TRMT61A -0.46 -6.65 -0.34 1.16e-10 Reticulocyte count; LUSC cis rs9309473 1.000 rs10187192 chr2:73713500 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -7.1 -0.36 7.47e-12 Metabolite levels; LUSC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg11062466 chr8:58055876 NA 0.51 7.05 0.36 1.06e-11 Developmental language disorder (linguistic errors); LUSC cis rs6840360 0.615 rs7695412 chr4:152488075 A/G cg22705602 chr4:152727874 NA -0.34 -6.84 -0.35 3.79e-11 Intelligence (multi-trait analysis); LUSC cis rs4805272 0.512 rs7260055 chr19:29341599 G/A cg12667521 chr19:29218732 NA 0.51 5.96 0.31 6.4e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9611565 0.649 rs139553 chr22:42187199 A/G cg06850241 chr22:41845214 NA 0.29 5.71 0.3 2.5e-8 Vitiligo; LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg27170947 chr2:26402098 FAM59B 0.71 10.74 0.51 2.59e-23 Gut microbiome composition (summer); LUSC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg09796270 chr17:17721594 SREBF1 -0.43 -7.55 -0.38 4.32e-13 Total body bone mineral density; LUSC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC cis rs12575480 0.637 rs7482782 chr11:2097954 C/T cg15541987 chr11:2077307 NA -0.43 -6.42 -0.33 4.59e-10 Pursuit maintenance gain; LUSC cis rs9921192 0.967 rs3747571 chr16:4323983 A/G cg00021532 chr16:4324280 TFAP4 0.79 14.34 0.62 1.08e-36 Prostate-specific antigen levels; LUSC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg09359103 chr1:154839909 KCNN3 -0.72 -16.65 -0.67 9.3e-46 Prostate cancer; LUSC trans rs34421088 0.532 rs1545073 chr8:11167700 C/T cg15556689 chr8:8085844 FLJ10661 0.4 6.01 0.31 4.74e-9 Neuroticism; LUSC cis rs13082711 0.522 rs640065 chr3:27363937 A/T cg02860705 chr3:27208620 NA 0.43 7.94 0.4 3.11e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7527798 0.592 rs11118337 chr1:207852693 G/C cg09232269 chr1:207846808 CR1L -0.29 -6.26 -0.32 1.21e-9 Erythrocyte sedimentation rate; LUSC cis rs11997175 1.000 rs6468200 chr8:33745191 A/T ch.8.33884649F chr8:33765107 NA 0.51 8.05 0.4 1.42e-14 Body mass index; LUSC cis rs6977660 0.607 rs7357321 chr7:19817636 C/T cg07541023 chr7:19748670 TWISTNB 0.58 6.3 0.33 9.55e-10 Thyroid stimulating hormone; LUSC cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg00033643 chr7:134001901 SLC35B4 0.44 6.82 0.35 4.34e-11 Mean platelet volume; LUSC cis rs2692947 0.599 rs7561198 chr2:96774981 C/G cg22654517 chr2:96458247 NA -0.32 -5.9 -0.31 9.11e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08642237 chr15:45694386 SPATA5L1 0.43 6.2 0.32 1.68e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs59104589 0.617 rs59487360 chr2:242270433 A/G cg14842376 chr2:242211374 HDLBP 0.58 6.52 0.34 2.54e-10 Fibrinogen levels; LUSC cis rs4654899 1.000 rs6697555 chr1:21287938 C/T cg01072550 chr1:21505969 NA -0.53 -8.16 -0.41 6.68e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg22875332 chr1:76189707 ACADM 0.79 11.11 0.52 1.32e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2880765 0.545 rs17553734 chr15:86013059 C/G cg10818794 chr15:86012489 AKAP13 0.42 6.49 0.33 3.03e-10 Coronary artery disease; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg15242686 chr22:24348715 GSTTP1 0.39 5.87 0.31 1.03e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7923609 0.967 rs7912893 chr10:65162000 T/A cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 3.84e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg13395646 chr4:1353034 KIAA1530 -0.64 -10.62 -0.5 6.98e-23 Obesity-related traits; LUSC cis rs3931020 0.688 rs277396 chr1:75213648 A/C cg10128416 chr1:75198403 TYW3;CRYZ -0.64 -8.55 -0.42 4.38e-16 Resistin levels; LUSC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg20573242 chr4:122745356 CCNA2 0.42 6.4 0.33 5.22e-10 Type 2 diabetes; LUSC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg20295408 chr7:1910781 MAD1L1 -0.45 -6.33 -0.33 7.85e-10 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.58 0.38 3.51e-13 Prudent dietary pattern; LUSC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg14582100 chr15:45693742 SPATA5L1 -0.57 -10.59 -0.5 8.49e-23 Homoarginine levels; LUSC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg23283495 chr1:209979779 IRF6 0.62 9.07 0.44 1.05e-17 Cleft lip with or without cleft palate; LUSC cis rs6905628 1 rs6905628 chr6:90344869 C/G cg23505970 chr6:90529759 MDN1 0.53 7.65 0.39 2.1e-13 Coronary artery disease; LUSC cis rs6460942 0.591 rs62448728 chr7:12332915 A/T cg06484146 chr7:12443880 VWDE -0.56 -5.89 -0.31 9.39e-9 Coronary artery disease; LUSC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg26818010 chr10:134567672 INPP5A -0.45 -6.82 -0.35 4.25e-11 Migraine; LUSC trans rs975730 0.801 rs6998301 chr8:129435018 A/G cg12887701 chr11:96123196 JRKL;CCDC82 0.37 6.06 0.31 3.64e-9 Celiac disease or Rheumatoid arthritis; LUSC cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg26384229 chr12:38710491 ALG10B 0.96 17.69 0.7 7.15e-50 Heart rate; LUSC cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg23625390 chr15:77176239 SCAPER 0.51 8.01 0.4 1.91e-14 Blood metabolite levels; LUSC cis rs9976767 0.637 rs2156309 chr21:43824529 G/A cg20516845 chr21:43823604 UBASH3A -0.25 -5.86 -0.31 1.12e-8 Type 1 diabetes; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg25036284 chr2:26402008 FAM59B -0.73 -10.66 -0.5 4.85e-23 Gut microbiome composition (summer); LUSC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg17252645 chr8:143867129 LY6D 0.37 6.56 0.34 2.08e-10 Urinary tract infection frequency; LUSC cis rs11214589 0.774 rs877137 chr11:113256330 C/T cg14159747 chr11:113255604 NA 0.31 8.0 0.4 2.04e-14 Neuroticism; LUSC cis rs1045714 0.895 rs61729413 chr7:2646796 G/A cg24848437 chr7:2645542 IQCE 0.6 6.92 0.35 2.29e-11 Urate levels in lean individuals; LUSC cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.12 -0.45 7.32e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.42 0.5 3.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1997103 1.000 rs4947504 chr7:55409428 T/C cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.11e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs724744 0.772 rs1737232 chr6:22351919 A/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.16 -0.32 2.06e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg13722127 chr7:150037890 RARRES2 0.38 5.7 0.3 2.63e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs1267303 0.642 rs6696219 chr1:47000408 T/C cg25110126 chr1:46999211 NA 0.73 10.68 0.5 4.35e-23 Monobrow; LUSC cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg01689657 chr7:91764605 CYP51A1 0.33 6.01 0.31 4.88e-9 Breast cancer; LUSC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs548181 0.609 rs511822 chr11:125534115 C/T cg03464685 chr11:125439445 EI24 1.22 14.61 0.62 9.8e-38 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17270561 0.609 rs4712960 chr6:25727265 C/T cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg23205692 chr1:25664452 TMEM50A 0.44 6.66 0.34 1.14e-10 Erythrocyte sedimentation rate; LUSC cis rs4423214 0.650 rs4245442 chr11:71220909 T/C cg05163923 chr11:71159392 DHCR7 0.65 8.21 0.41 4.97e-15 Vitamin D levels; LUSC cis rs2806561 0.704 rs2806570 chr1:23527005 C/T cg19743168 chr1:23544995 NA -0.45 -8.99 -0.44 1.86e-17 Height; LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg27284194 chr4:1044797 NA 0.36 5.65 0.3 3.46e-8 Longevity; LUSC cis rs4237845 0.537 rs10747786 chr12:58260601 G/T cg02175503 chr12:58329896 NA 0.46 6.8 0.35 4.91e-11 Intelligence (multi-trait analysis); LUSC cis rs614226 1.000 rs541126 chr12:120972396 C/T cg21053147 chr12:120880522 NA 0.49 6.08 0.32 3.34e-9 Type 1 diabetes nephropathy; LUSC trans rs4332037 0.539 rs868754 chr7:2033780 G/C cg10840412 chr1:235813424 GNG4 0.57 7.12 0.36 6.73e-12 Bipolar disorder; LUSC cis rs61931739 0.517 rs10772139 chr12:34186178 A/T cg06521331 chr12:34319734 NA -0.45 -7.38 -0.37 1.29e-12 Morning vs. evening chronotype; LUSC cis rs61931739 0.929 rs10844730 chr12:34026721 C/G cg06521331 chr12:34319734 NA 0.38 6.34 0.33 7.51e-10 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg08807101 chr21:30365312 RNF160 -0.72 -12.81 -0.57 7.8e-31 Dental caries; LUSC cis rs8058578 0.943 rs3747486 chr16:30786927 C/T cg05768032 chr16:30646687 NA 0.4 5.94 0.31 7.12e-9 Multiple myeloma; LUSC cis rs8170 0.603 rs11086068 chr19:17420165 T/C cg04749549 chr19:17459798 NA -0.31 -5.76 -0.3 1.94e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC cis rs68170813 0.559 rs7809508 chr7:107004119 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.71 -0.47 8.68e-20 Coronary artery disease; LUSC cis rs12367572 0.930 rs11615964 chr12:45261564 C/T cg04608330 chr12:45269318 NELL2 -0.56 -8.8 -0.43 7.39e-17 Gut microbiome composition (summer); LUSC cis rs656319 0.625 rs4526366 chr8:9890179 C/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.22 -0.32 1.51e-9 Myopia (pathological); LUSC cis rs7107174 0.688 rs869202 chr11:78127914 A/G cg02023728 chr11:77925099 USP35 0.43 6.58 0.34 1.77e-10 Testicular germ cell tumor; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg24503407 chr1:205819492 PM20D1 0.77 13.1 0.58 6.19e-32 Menarche (age at onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg15826130 chr11:67159072 LOC100130987;RAD9A -0.47 -6.36 -0.33 6.5e-10 Hepatitis; LUSC cis rs6964587 0.967 rs6974827 chr7:91772945 C/T cg17063962 chr7:91808500 NA 0.6 9.65 0.47 1.34e-19 Breast cancer; LUSC cis rs1595825 0.945 rs76510735 chr2:198823095 G/A cg00982548 chr2:198649783 BOLL -0.58 -7.29 -0.37 2.32e-12 Ulcerative colitis; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg04775059 chr7:64541387 NA 0.49 7.15 0.36 5.64e-12 Calcium levels; LUSC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC trans rs12310956 0.510 rs1565026 chr12:33887499 A/G cg13010199 chr12:38710504 ALG10B 0.45 7.04 0.36 1.13e-11 Morning vs. evening chronotype; LUSC cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.51 -7.39 -0.37 1.21e-12 Axial length; LUSC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg20811857 chr17:78079795 GAA -0.32 -5.9 -0.31 8.87e-9 Yeast infection; LUSC cis rs7666738 0.546 rs17546687 chr4:98769266 T/A cg03676636 chr4:99064102 C4orf37 0.3 5.88 0.31 1e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs11190604 1.000 rs76683169 chr10:102358397 A/T cg07080220 chr10:102295463 HIF1AN 0.62 7.49 0.38 6.32e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9788721 1.000 rs8031948 chr15:78816057 G/T cg06917634 chr15:78832804 PSMA4 -0.46 -6.32 -0.33 8.28e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16249355 chr17:76310516 NA -0.49 -6.59 -0.34 1.67e-10 Bipolar disorder and schizophrenia; LUSC cis rs11122272 0.701 rs2749702 chr1:231523808 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs4363385 0.510 rs7543689 chr1:153046803 A/T cg00922841 chr1:152955080 SPRR1A -0.38 -6.39 -0.33 5.43e-10 Inflammatory skin disease; LUSC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg09165964 chr15:75287851 SCAMP5 -1.02 -15.28 -0.64 2.35e-40 Blood trace element (Zn levels); LUSC cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg13256891 chr4:100009986 ADH5 -0.44 -6.04 -0.31 4.16e-9 Alcohol dependence; LUSC cis rs12519773 1.000 rs995620 chr5:92452676 A/C cg18783429 chr5:92414398 NA 0.29 6.38 0.33 6.07e-10 Migraine; LUSC cis rs9398803 0.931 rs1361262 chr6:126701967 T/C cg19875578 chr6:126661172 C6orf173 0.41 6.1 0.32 2.95e-9 Male-pattern baldness; LUSC cis rs965469 1.000 rs2281503 chr20:3263636 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -5.93 -0.31 7.54e-9 IFN-related cytopenia; LUSC cis rs12893668 0.644 rs12890820 chr14:104034849 T/C cg08213375 chr14:104286397 PPP1R13B 0.38 6.22 0.32 1.48e-9 Reticulocyte count; LUSC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg07424592 chr7:64974309 NA -0.65 -5.75 -0.3 1.99e-8 Diabetic kidney disease; LUSC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs752010 0.574 rs12130138 chr1:42117792 A/C cg06885757 chr1:42089581 HIVEP3 0.44 9.19 0.45 4.4e-18 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.98 19.75 0.73 4.65e-58 Subjective well-being; LUSC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.8 -15.16 -0.64 7.29e-40 Age at first birth; LUSC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg02503808 chr4:7069936 GRPEL1 1.05 14.94 0.63 5.16e-39 Monocyte percentage of white cells; LUSC trans rs72674100 1.000 rs77619190 chr4:97991906 C/A cg16405019 chr1:18959625 PAX7 -0.61 -6.0 -0.31 5.27e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.63 -0.34 1.32e-10 Bipolar disorder and schizophrenia; LUSC cis rs4499344 0.730 rs7247597 chr19:33102257 C/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs3806843 0.568 rs2530232 chr5:140082878 A/G cg19875535 chr5:140030758 IK -0.53 -8.55 -0.42 4.42e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs6964587 1.000 rs10270598 chr7:91700827 T/C cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.5e-8 Breast cancer; LUSC cis rs7771547 0.642 rs595954 chr6:36464834 C/G cg07856975 chr6:36356162 ETV7 0.35 6.2 0.32 1.69e-9 Platelet distribution width; LUSC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg20821713 chr7:1055600 C7orf50 -0.54 -7.1 -0.36 7.69e-12 Bronchopulmonary dysplasia; LUSC cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg05347473 chr6:146136440 FBXO30 -0.48 -8.11 -0.41 9.71e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs7615952 0.641 rs2365019 chr3:125808135 T/C cg07211511 chr3:129823064 LOC729375 -0.75 -9.68 -0.47 1.1e-19 Blood pressure (smoking interaction); LUSC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg09323728 chr8:95962352 TP53INP1 -0.39 -7.79 -0.39 8.44e-14 Type 2 diabetes; LUSC cis rs11997175 0.583 rs7829680 chr8:33794207 C/T ch.8.33884649F chr8:33765107 NA -0.46 -6.77 -0.35 5.71e-11 Body mass index; LUSC cis rs6685188 0.925 rs12752037 chr1:205661614 A/C cg11965913 chr1:205819406 PM20D1 -0.47 -7.17 -0.37 4.82e-12 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg13256891 chr4:100009986 ADH5 0.48 7.11 0.36 7.05e-12 Alcohol dependence; LUSC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.2 -0.32 1.62e-9 Life satisfaction; LUSC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg01657329 chr11:68192670 LRP5 0.45 7.24 0.37 3.04e-12 Total body bone mineral density; LUSC cis rs13089785 0.791 rs16834826 chr3:123584488 C/T cg02558132 chr3:123411198 MYLK -0.36 -6.3 -0.33 9.25e-10 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg21132104 chr15:45694354 SPATA5L1 0.56 7.75 0.39 1.08e-13 Homoarginine levels; LUSC cis rs11645898 0.935 rs4788605 chr16:72154682 G/T cg14768367 chr16:72042858 DHODH -0.64 -7.35 -0.37 1.52e-12 Blood protein levels; LUSC cis rs1712517 0.566 rs7076274 chr10:105046007 G/A cg04362960 chr10:104952993 NT5C2 -0.49 -6.66 -0.34 1.1e-10 Migraine; LUSC cis rs9300255 0.596 rs7304782 chr12:123719444 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.36 6.59 0.34 1.75e-10 Neutrophil percentage of white cells; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs6460942 0.591 rs4721082 chr7:12341804 A/G cg06484146 chr7:12443880 VWDE -0.59 -6.24 -0.32 1.36e-9 Coronary artery disease; LUSC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg05347473 chr6:146136440 FBXO30 0.58 10.07 0.48 5.23e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs12618769 0.652 rs11537554 chr2:99216531 A/G cg10123293 chr2:99228465 UNC50 0.47 7.7 0.39 1.59e-13 Bipolar disorder; LUSC cis rs950169 0.922 rs11639244 chr15:84832650 G/A cg17507749 chr15:85114479 UBE2QP1 0.67 8.72 0.43 1.32e-16 Schizophrenia; LUSC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7113850 0.541 rs61875405 chr11:24376359 G/A ch.11.24196551F chr11:24239977 NA 0.65 5.73 0.3 2.18e-8 Bone fracture in osteoporosis; LUSC cis rs7833986 1.000 rs34516759 chr8:57097138 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 9.2 0.45 3.84e-18 Height; LUSC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg12826209 chr6:26865740 GUSBL1 -0.76 -9.94 -0.48 1.48e-20 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg03576123 chr11:487126 PTDSS2 -0.97 -10.78 -0.51 1.95e-23 Body mass index; LUSC trans rs17685 0.753 rs13240967 chr7:75658197 C/T cg19862616 chr7:65841803 NCRNA00174 -1.14 -20.35 -0.74 1.94e-60 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs3749237 0.964 rs2352967 chr3:49871641 C/T cg21659725 chr3:3221576 CRBN 0.6 8.72 0.43 1.32e-16 Resting heart rate; LUSC cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -9.04 -0.44 1.27e-17 Axial length; LUSC cis rs12541635 0.677 rs2029880 chr8:107024649 T/C cg10147462 chr8:107024639 NA 0.68 14.15 0.61 5.93e-36 Age of smoking initiation; LUSC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg00376283 chr12:123451042 ABCB9 0.65 8.33 0.41 2.18e-15 Neutrophil percentage of white cells; LUSC cis rs3755132 0.852 rs2302937 chr2:15770061 G/A cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.92 0.31 7.94e-9 Lung cancer; LUSC cis rs1371867 0.846 rs1692006 chr8:101252462 C/T cg06636551 chr8:101224915 SPAG1 0.38 7.08 0.36 8.4e-12 Atrioventricular conduction; LUSC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg06022373 chr22:39101656 GTPBP1 0.84 14.01 0.61 2.07e-35 Menopause (age at onset); LUSC cis rs4478858 0.684 rs4949373 chr1:31741577 G/A cg00250761 chr1:31883323 NA -0.33 -7.95 -0.4 2.9e-14 Alcohol dependence; LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg24675658 chr1:53192096 ZYG11B 0.6 9.33 0.45 1.51e-18 Monocyte count; LUSC cis rs3849570 1.000 rs11711331 chr3:81819040 A/G cg07356753 chr3:81810745 GBE1 0.68 10.96 0.51 4.39e-24 Waist circumference;Body mass index; LUSC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg08508325 chr11:3079039 CARS 0.46 10.84 0.51 1.2e-23 Longevity; LUSC cis rs6484504 0.576 rs158146 chr11:31210433 G/A cg06552810 chr11:31128660 NA -0.4 -7.17 -0.37 4.73e-12 Red blood cell count; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg02757194 chr11:44748427 NA 0.66 6.29 0.33 1.01e-9 Myocardial infarction; LUSC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg16006841 chr5:176797999 RGS14 0.65 10.5 0.5 1.79e-22 Hemoglobin concentration;Hematocrit; LUSC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg19592336 chr6:28129416 ZNF389 0.48 5.92 0.31 7.9e-9 Parkinson's disease; LUSC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC cis rs10992471 0.603 rs755209 chr9:95489671 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -5.64 -0.3 3.58e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.49 -9.43 -0.46 7.05e-19 Axial length; LUSC cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg05347473 chr6:146136440 FBXO30 -0.41 -6.91 -0.35 2.48e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg24675056 chr1:15929824 NA 0.44 7.57 0.38 3.66e-13 Systolic blood pressure; LUSC cis rs10489202 0.608 rs6657019 chr1:168079669 T/C cg24449463 chr1:168025552 DCAF6 -0.63 -9.47 -0.46 5.4e-19 Schizophrenia; LUSC cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg23158103 chr7:148848205 ZNF398 -0.45 -7.5 -0.38 5.76e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs113084984 0.816 rs4669749 chr2:11692664 A/C cg07314298 chr2:11723111 GREB1 -0.4 -5.96 -0.31 6.26e-9 Breast cancer; LUSC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg27494647 chr7:150038898 RARRES2 0.51 7.86 0.4 5.3e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs7818345 0.904 rs6997164 chr8:19287856 G/T cg11303988 chr8:19266685 CSGALNACT1 0.35 6.64 0.34 1.28e-10 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg23985595 chr17:80112537 CCDC57 0.31 5.94 0.31 7.01e-9 Life satisfaction; LUSC cis rs908922 0.676 rs7545336 chr1:152527863 A/G cg20991723 chr1:152506922 NA 0.49 9.23 0.45 3.09e-18 Hair morphology; LUSC cis rs7727544 0.582 rs3792894 chr5:131547271 C/T cg24060327 chr5:131705240 SLC22A5 -0.34 -5.67 -0.3 3.12e-8 Blood metabolite levels; LUSC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg12963246 chr6:28129442 ZNF389 0.55 7.63 0.39 2.55e-13 Depression; LUSC cis rs7296418 0.738 rs10846489 chr12:123743927 A/G cg00376283 chr12:123451042 ABCB9 -0.72 -10.97 -0.51 4.12e-24 Platelet count; LUSC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg18230493 chr5:56204884 C5orf35 -0.95 -14.26 -0.62 2.34e-36 Initial pursuit acceleration; LUSC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg09359103 chr1:154839909 KCNN3 -0.72 -17.47 -0.69 5.45e-49 Prostate cancer; LUSC cis rs8017423 0.967 rs6575117 chr14:90715412 G/A cg14092571 chr14:90743983 NA -0.36 -5.8 -0.3 1.55e-8 Mortality in heart failure; LUSC cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.54 7.49 0.38 6.25e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6840360 0.615 rs72728179 chr4:152477877 A/G cg22705602 chr4:152727874 NA -0.32 -6.49 -0.33 3.05e-10 Intelligence (multi-trait analysis); LUSC cis rs72634258 0.945 rs12727642 chr1:8046672 C/A cg00042356 chr1:8021962 PARK7 0.77 9.78 0.47 5.03e-20 Inflammatory bowel disease; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg13397359 chr6:42928475 GNMT 0.63 10.5 0.5 1.78e-22 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1670533 1.000 rs7685541 chr4:1058501 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.03 0.31 4.23e-9 Recombination rate (females); LUSC cis rs425277 1.000 rs381664 chr1:2088104 A/G cg03732007 chr1:2071316 PRKCZ 0.46 7.45 0.38 7.84e-13 Height; LUSC cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.44 -6.43 -0.33 4.51e-10 Eosinophil percentage of white cells; LUSC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg12927641 chr6:109611667 NA -0.36 -6.12 -0.32 2.57e-9 Reticulocyte fraction of red cells; LUSC trans rs1325195 0.920 rs2793812 chr1:179159399 C/A cg11624085 chr17:8464688 MYH10 0.41 6.64 0.34 1.29e-10 IgE grass sensitization; LUSC cis rs2795502 1.000 rs2796575 chr10:43374911 A/G cg20628663 chr10:43360327 NA 0.76 10.64 0.5 6.04e-23 Blood protein levels; LUSC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg04756594 chr16:24857601 SLC5A11 0.46 6.45 0.33 4.02e-10 Intelligence (multi-trait analysis); LUSC cis rs2742234 0.955 rs2075913 chr10:43622368 T/A cg02780029 chr10:43622663 RET -0.36 -6.89 -0.35 2.74e-11 Hirschsprung disease; LUSC cis rs6681460 0.549 rs1373909 chr1:67040875 A/G cg02459107 chr1:67143332 SGIP1 0.32 5.78 0.3 1.75e-8 Presence of antiphospholipid antibodies; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.94e-10 Menopause (age at onset); LUSC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg20243544 chr17:37824526 PNMT 0.5 7.06 0.36 9.93e-12 Asthma; LUSC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 8.72 0.43 1.28e-16 Alzheimer's disease; LUSC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg12560992 chr17:57184187 TRIM37 -0.84 -15.34 -0.64 1.48e-40 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg09184832 chr6:79620586 NA -0.42 -6.79 -0.35 5.28e-11 Intelligence (multi-trait analysis); LUSC cis rs7833986 1.000 rs13281873 chr8:57101799 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 8.74 0.43 1.18e-16 Height; LUSC cis rs1790761 0.692 rs638140 chr11:67333858 G/C cg14500267 chr11:67383377 NA 0.34 6.43 0.33 4.37e-10 Mean corpuscular volume; LUSC trans rs11123259 0.761 rs34232809 chr2:115711243 C/A cg00844339 chr9:138873417 NA 0.29 5.99 0.31 5.29e-9 Gut microbiome composition (winter); LUSC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 6.31 0.33 8.66e-10 Parkinson's disease; LUSC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg00074818 chr8:8560427 CLDN23 0.57 9.69 0.47 1.01e-19 Obesity-related traits; LUSC cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.1e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs2243480 1.000 rs1553174 chr7:65731194 T/C cg10756647 chr7:56101905 PSPH -0.87 -8.66 -0.43 2.02e-16 Diabetic kidney disease; LUSC cis rs4148883 0.713 rs3828541 chr4:100042262 A/G cg12011299 chr4:100065546 ADH4 0.47 7.91 0.4 3.88e-14 Alcohol dependence; LUSC trans rs3749237 1.000 rs4768 chr3:49758764 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.51 7.02 0.36 1.28e-11 Resting heart rate; LUSC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg21963583 chr11:68658836 MRPL21 -0.5 -7.47 -0.38 6.91e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs2228479 0.850 rs1800339 chr16:89839637 C/A cg24644049 chr4:85504048 CDS1 0.86 7.56 0.38 3.83e-13 Skin colour saturation; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg02951883 chr7:2050386 MAD1L1 -0.61 -11.67 -0.54 1.29e-26 Bipolar disorder and schizophrenia; LUSC cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg14983838 chr19:29218262 NA 0.65 9.14 0.45 6.14e-18 Methadone dose in opioid dependence; LUSC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs12893668 0.703 rs34186780 chr14:104027595 T/G cg01849466 chr14:104193079 ZFYVE21 -0.42 -5.73 -0.3 2.28e-8 Reticulocyte count; LUSC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.81 0.35 4.59e-11 Intelligence (multi-trait analysis); LUSC cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg22508957 chr16:3507546 NAT15 0.66 11.04 0.52 2.2e-24 Tuberculosis; LUSC cis rs6542838 0.703 rs7593332 chr2:99467991 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.53 -7.28 -0.37 2.42e-12 Fear of minor pain; LUSC cis rs77633900 0.614 rs280001 chr15:77003566 C/A cg21673338 chr15:77095150 SCAPER -0.78 -7.97 -0.4 2.54e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs4660306 1.000 rs1044717 chr1:45976587 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -7.04 -0.36 1.12e-11 Homocysteine levels; LUSC cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg05283184 chr6:79620031 NA -0.46 -8.68 -0.43 1.78e-16 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.545 rs10755377 chr6:79637925 T/C cg05283184 chr6:79620031 NA -0.45 -8.54 -0.42 4.85e-16 Intelligence (multi-trait analysis); LUSC cis rs612683 0.664 rs6702766 chr1:100997635 A/G cg06223162 chr1:101003688 GPR88 -0.54 -9.93 -0.48 1.58e-20 Breast cancer; LUSC cis rs7296418 0.961 rs1790121 chr12:123604492 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.89 -0.35 2.7e-11 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22109331 chr1:212003961 LPGAT1 0.39 5.96 0.31 6.42e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9457247 0.902 rs366938 chr6:167403538 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs2760061 0.819 rs3094914 chr1:228206934 C/T cg04850211 chr1:228464232 OBSCN -0.32 -5.75 -0.3 1.98e-8 Diastolic blood pressure; LUSC cis rs861020 0.710 rs7516902 chr1:210022179 A/G cg05527609 chr1:210001259 C1orf107 1.03 14.69 0.63 5.02e-38 Orofacial clefts; LUSC cis rs6840360 0.615 rs4696097 chr4:152479765 C/T cg22705602 chr4:152727874 NA 0.33 6.61 0.34 1.55e-10 Intelligence (multi-trait analysis); LUSC cis rs7246967 0.673 rs7250620 chr19:22853126 A/T cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg27165867 chr14:105738592 BRF1 -0.5 -7.08 -0.36 8.81e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs7937682 0.889 rs564086 chr11:111501079 C/G cg22437258 chr11:111473054 SIK2 0.52 7.01 0.36 1.29e-11 Primary sclerosing cholangitis; LUSC cis rs983392 0.709 rs11230194 chr11:59980315 C/G cg24026212 chr11:59952134 MS4A6A -0.35 -6.09 -0.32 3.18e-9 Alzheimer's disease (late onset); LUSC cis rs4595586 0.545 rs7970307 chr12:39380760 A/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs3820928 0.810 rs10175929 chr2:227858609 T/C cg11843606 chr2:227700838 RHBDD1 -0.51 -7.3 -0.37 2.17e-12 Pulmonary function; LUSC cis rs17401966 1.000 rs12755094 chr1:10305711 T/C cg19773385 chr1:10388646 KIF1B -0.55 -8.69 -0.43 1.6e-16 Hepatocellular carcinoma; LUSC cis rs2236521 0.714 rs6062210 chr20:60890375 A/G cg09594475 chr20:60884601 LAMA5 0.37 5.87 0.31 1.06e-8 Pelvic organ prolapse; LUSC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs7789940 0.904 rs56919252 chr7:75937520 T/C cg10167463 chr7:75959203 YWHAG -0.6 -8.74 -0.43 1.13e-16 Multiple sclerosis; LUSC cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg23583168 chr7:148888333 NA -0.92 -17.41 -0.69 9.48e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs208520 0.789 rs9351549 chr6:66871851 A/G cg07460842 chr6:66804631 NA -1.11 -16.92 -0.68 7.88e-47 Exhaled nitric oxide output; LUSC cis rs2832191 0.716 rs8132085 chr21:30501389 G/T cg08807101 chr21:30365312 RNF160 -0.76 -13.61 -0.6 7.47e-34 Dental caries; LUSC cis rs4494114 0.967 rs9438986 chr1:39369652 T/G cg25970120 chr1:39325951 RRAGC -0.41 -6.33 -0.33 7.9e-10 Blood protein levels; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg11218175 chr11:495084 RNH1 0.53 5.71 0.3 2.51e-8 Body mass index; LUSC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg16228356 chr17:43848958 NA -0.26 -5.98 -0.31 5.81e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg04362960 chr10:104952993 NT5C2 0.64 9.89 0.48 2.21e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11997175 0.603 rs7462153 chr8:33814607 C/T ch.8.33884649F chr8:33765107 NA 0.41 6.2 0.32 1.65e-9 Body mass index; LUSC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.63e-8 Depression; LUSC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11890956 chr21:40555474 PSMG1 -0.92 -16.47 -0.67 4.8e-45 Cognitive function; LUSC cis rs7707921 1.000 rs1543911 chr5:81504841 C/T cg15871215 chr5:81402204 ATG10 0.45 6.61 0.34 1.53e-10 Breast cancer; LUSC cis rs9311676 0.656 rs7620012 chr3:58373716 G/A cg26110898 chr3:58419937 PDHB 0.42 6.75 0.35 6.62e-11 Systemic lupus erythematosus; LUSC cis rs11711311 0.955 rs12636240 chr3:113391282 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -6.33 -0.33 7.85e-10 IgG glycosylation; LUSC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg11764359 chr7:65958608 NA -0.79 -13.29 -0.59 1.17e-32 Aortic root size; LUSC cis rs1577917 1.000 rs1995688 chr6:86632319 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.26 -0.41 3.4e-15 Response to antipsychotic treatment; LUSC cis rs709400 0.628 rs2273700 chr14:103923414 A/G cg12935359 chr14:103987150 CKB -0.56 -8.6 -0.43 3.12e-16 Body mass index; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg01238044 chr22:24384105 GSTT1 -0.57 -8.43 -0.42 1.06e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19717773 chr7:2847554 GNA12 -0.34 -5.65 -0.3 3.48e-8 Height; LUSC cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg04586622 chr2:25135609 ADCY3 0.42 8.87 0.44 4.58e-17 Body mass index; LUSC trans rs7939886 0.920 rs12224086 chr11:55798259 G/T cg03929089 chr4:120376271 NA 0.74 6.25 0.32 1.29e-9 Myopia (pathological); LUSC trans rs9929218 1.000 rs12446407 chr16:68804068 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.6 -0.54 2.29e-26 Colorectal cancer; LUSC cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg03146154 chr1:46216737 IPP 0.54 8.11 0.41 9.83e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11676348 0.774 rs13397673 chr2:219047782 A/G cg00012203 chr2:219082015 ARPC2 -0.58 -9.47 -0.46 5.16e-19 Ulcerative colitis; LUSC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg20818283 chr2:191399100 TMEM194B -0.42 -6.47 -0.33 3.45e-10 Pulse pressure; LUSC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC trans rs12310956 0.532 rs11052951 chr12:33986181 T/A cg26384229 chr12:38710491 ALG10B 0.65 10.29 0.49 9.41e-22 Morning vs. evening chronotype; LUSC cis rs9304742 0.854 rs11084211 chr19:53460861 C/T cg09915433 chr19:53449742 NA -0.6 -9.55 -0.46 2.98e-19 Psoriasis; LUSC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg17366294 chr4:99064904 C4orf37 -0.59 -10.53 -0.5 1.38e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs10097731 0.901 rs10464892 chr8:82042991 A/G cg25230327 chr8:82042993 NA 0.42 6.21 0.32 1.6e-9 Serum total protein level; LUSC cis rs561341 0.609 rs4795659 chr17:30187139 C/G cg00745463 chr17:30367425 LRRC37B 0.63 7.58 0.38 3.37e-13 Hip circumference adjusted for BMI; LUSC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg10207240 chr12:122356781 WDR66 0.48 6.81 0.35 4.6e-11 Mean corpuscular volume; LUSC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg10057126 chr4:77819792 ANKRD56 0.54 7.97 0.4 2.5e-14 Emphysema distribution in smoking; LUSC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs9399135 0.773 rs949895 chr6:135405359 C/T cg24558204 chr6:135376177 HBS1L 0.44 6.28 0.32 1.08e-9 Red blood cell count; LUSC cis rs7937682 0.889 rs1789355 chr11:111499718 T/C cg22437258 chr11:111473054 SIK2 0.52 7.05 0.36 1.03e-11 Primary sclerosing cholangitis; LUSC cis rs6580649 0.943 rs1859444 chr12:48399403 T/C cg24011408 chr12:48396354 COL2A1 0.53 7.31 0.37 2e-12 Lung cancer; LUSC cis rs2274273 0.805 rs60972460 chr14:55571773 A/T cg04306507 chr14:55594613 LGALS3 0.54 12.18 0.55 1.78e-28 Protein biomarker; LUSC trans rs7824557 0.583 rs2263511 chr8:11233318 A/C cg08975724 chr8:8085496 FLJ10661 -0.46 -6.77 -0.35 5.85e-11 Retinal vascular caliber; LUSC cis rs1577917 1.000 rs1999852 chr6:86705738 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.32 -0.41 2.25e-15 Response to antipsychotic treatment; LUSC cis rs889512 0.642 rs28595463 chr16:75281235 C/T cg04987608 chr16:75300043 BCAR1 -0.5 -5.74 -0.3 2.07e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg17848003 chr1:3704513 LRRC47 0.32 5.82 0.3 1.35e-8 Red cell distribution width; LUSC cis rs11098499 0.754 rs12510269 chr4:120241646 A/G cg09307838 chr4:120376055 NA 0.69 10.46 0.5 2.53e-22 Corneal astigmatism; LUSC cis rs4820539 1.000 rs4822362 chr22:23482744 C/A cg14186256 chr22:23484241 RTDR1 0.97 18.3 0.71 2.62e-52 Bone mineral density; LUSC cis rs3213961 0.554 rs8256 chr2:33789068 C/G cg04131969 chr2:33951647 MYADML 0.49 5.92 0.31 7.81e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs9399135 0.967 rs3756799 chr6:135341011 A/G cg22676075 chr6:135203613 NA 0.47 7.39 0.37 1.2e-12 Red blood cell count; LUSC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg20399509 chr21:47717575 C21orf57 0.43 6.34 0.33 7.67e-10 Testicular germ cell tumor; LUSC trans rs3857536 0.813 rs2040591 chr6:66945915 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.3 0.37 2.12e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2041895 0.509 rs1035236 chr12:107310797 C/T cg13944111 chr12:107296891 NA 0.38 6.7 0.34 8.87e-11 Glaucoma (low intraocular pressure); LUSC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -8.04 -0.4 1.6e-14 Cystic fibrosis severity; LUSC cis rs7605827 0.930 rs879972 chr2:15703031 G/C cg19274914 chr2:15703543 NA 0.46 8.64 0.43 2.43e-16 Educational attainment (years of education); LUSC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.67e-9 Systolic blood pressure; LUSC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg22823121 chr1:150693482 HORMAD1 0.49 7.2 0.37 4.13e-12 Melanoma; LUSC cis rs1670533 1.000 rs6852558 chr4:1059944 C/T cg27284194 chr4:1044797 NA 0.6 8.76 0.43 9.9900000000000006e-17 Recombination rate (females); LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg27094323 chr7:1216898 NA -0.47 -8.4 -0.42 1.32e-15 Longevity;Endometriosis; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg11574612 chr6:46620502 CYP39A1;SLC25A27 0.49 6.09 0.32 3.04e-9 Cognitive function;Information processing speed; LUSC cis rs2857891 0.695 rs2857887 chr11:6984001 A/G cg04053776 chr11:6947353 ZNF215 0.41 6.0 0.31 5.23e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg02569458 chr12:86230093 RASSF9 0.54 8.82 0.43 6.7e-17 Major depressive disorder; LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg13395646 chr4:1353034 KIAA1530 0.59 9.04 0.44 1.33e-17 Obesity-related traits; LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg21724239 chr8:58056113 NA 0.78 9.32 0.45 1.58e-18 Developmental language disorder (linguistic errors); LUSC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -6.9 -0.35 2.59e-11 Alzheimer's disease (late onset); LUSC cis rs6693567 0.545 rs1313568 chr1:150344180 C/G cg15654264 chr1:150340011 RPRD2 0.46 7.35 0.37 1.5e-12 Migraine; LUSC cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg01884057 chr2:25150051 NA 0.42 9.13 0.45 6.57e-18 Body mass index; LUSC cis rs796364 0.589 rs6743217 chr2:201134914 G/A cg23649088 chr2:200775458 C2orf69 -0.57 -7.78 -0.39 8.85e-14 Schizophrenia; LUSC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg21644426 chr2:191273491 MFSD6 -0.59 -9.41 -0.46 8.53e-19 Pulse pressure; LUSC cis rs228769 0.635 rs228754 chr17:42116056 C/A cg19774624 chr17:42201019 HDAC5 0.59 7.24 0.37 3.09e-12 Bone mineral density (hip);Bone mineral density (spine); LUSC cis rs28830936 1.000 rs11629485 chr15:41904569 C/T cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.24 -0.32 1.31e-9 Diastolic blood pressure; LUSC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg03351412 chr1:154909251 PMVK 0.52 8.08 0.4 1.18e-14 Prostate cancer; LUSC cis rs1801251 1.000 rs13035829 chr2:233604487 A/T cg08000102 chr2:233561755 GIGYF2 0.69 11.4 0.53 1.22e-25 Coronary artery disease; LUSC cis rs807669 0.772 rs809901 chr22:19228736 C/T cg02655711 chr22:19163373 SLC25A1 0.75 14.66 0.63 6.23e-38 Metabolite levels; LUSC trans rs8002861 0.840 rs1819596 chr13:44429554 A/G cg12856521 chr11:46389249 DGKZ 0.4 6.37 0.33 6.37e-10 Leprosy; LUSC cis rs3020736 0.500 rs1801311 chr22:42486723 G/A cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.78 -0.3 1.71e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs4285028 0.747 rs12496318 chr3:121561500 A/C cg11130432 chr3:121712080 ILDR1 0.58 7.51 0.38 5.46e-13 Multiple sclerosis; LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg27535305 chr1:53392650 SCP2 -0.4 -7.47 -0.38 6.86e-13 Monocyte count; LUSC cis rs4888262 0.564 rs8062404 chr16:74611675 T/C cg01733217 chr16:74700730 RFWD3 0.75 12.2 0.56 1.51e-28 Testicular germ cell tumor; LUSC cis rs9660992 0.967 rs1172135 chr1:205247160 G/C cg21643547 chr1:205240462 TMCC2 -0.48 -9.06 -0.44 1.1e-17 Mean corpuscular volume;Mean platelet volume; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10010376 chr1:144932311 PDE4DIP -0.4 -5.96 -0.31 6.48e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg06453172 chr10:134556979 INPP5A -0.5 -6.35 -0.33 6.9e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg09034736 chr1:150693464 HORMAD1 0.44 6.02 0.31 4.65e-9 Melanoma; LUSC cis rs4417855 0.665 rs6444247 chr3:187413221 G/A cg19198148 chr3:187451818 BCL6 0.56 9.81 0.47 4.1e-20 Granulocyte percentage of myeloid white cells; LUSC cis rs1348850 0.609 rs1348851 chr2:178418677 C/T cg22681709 chr2:178499509 PDE11A 0.42 5.83 0.3 1.31e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7572733 0.576 rs1865586 chr2:198758868 C/T cg00792783 chr2:198669748 PLCL1 -0.45 -6.2 -0.32 1.68e-9 Dermatomyositis; LUSC cis rs12594515 1.000 rs8025258 chr15:45987554 C/A cg06207120 chr15:45996521 NA 0.4 6.22 0.32 1.48e-9 Waist circumference;Weight; LUSC cis rs7923609 0.871 rs2393984 chr10:65314971 A/G cg01631684 chr10:65280961 REEP3 0.41 6.05 0.31 3.84e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs1949733 0.628 rs2688231 chr4:8490981 G/A cg13073564 chr4:8508604 NA -0.45 -8.87 -0.44 4.37e-17 Response to antineoplastic agents; LUSC cis rs6987853 0.787 rs2923413 chr8:42455308 A/G cg09913449 chr8:42400586 C8orf40 0.44 7.42 0.38 9.89e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs116988415 0.584 rs4902311 chr14:65241933 G/A cg25083366 chr14:65239357 SPTB 0.66 6.37 0.33 6.41e-10 Daytime sleep phenotypes; LUSC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg08439880 chr3:133502540 NA -0.34 -6.08 -0.32 3.32e-9 Iron status biomarkers; LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs2370759 1.000 rs11597888 chr10:32635834 G/A cg01819863 chr10:32635814 EPC1 1.05 12.84 0.57 6.06e-31 Sexual dysfunction (female); LUSC cis rs921968 0.542 rs630858 chr2:219409689 C/A cg02176678 chr2:219576539 TTLL4 0.74 14.55 0.62 1.7e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs9403521 1.000 rs9390126 chr6:143980432 A/G cg18240653 chr6:144019428 PHACTR2 -0.51 -6.16 -0.32 2.11e-9 Obesity-related traits; LUSC cis rs4969178 0.965 rs11077362 chr17:76397219 A/T cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs61931739 0.890 rs1705753 chr12:34144594 C/T cg06521331 chr12:34319734 NA -0.37 -6.31 -0.33 8.7e-10 Morning vs. evening chronotype; LUSC cis rs372883 0.901 rs13048365 chr21:30740394 T/C cg24692254 chr21:30365293 RNF160 0.41 5.85 0.3 1.2e-8 Pancreatic cancer; LUSC cis rs136211 0.619 rs9607337 chr22:36758849 A/T cg16924664 chr22:36878180 TXN2 0.38 5.79 0.3 1.58e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 13.58 0.6 9.53e-34 Platelet count; LUSC cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg13010199 chr12:38710504 ALG10B 0.7 11.58 0.54 2.64e-26 Heart rate; LUSC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg18827107 chr12:86230957 RASSF9 0.46 6.92 0.35 2.36e-11 Major depressive disorder; LUSC cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs243505 0.894 rs243504 chr7:148435393 A/G cg09806900 chr7:148480153 CUL1 -0.48 -6.92 -0.35 2.35e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.46 -6.71 -0.34 8.37e-11 Gut microbiome composition (summer); LUSC cis rs11758351 0.925 rs78932312 chr6:26194869 A/G cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg05535760 chr7:792225 HEATR2 0.91 9.57 0.46 2.42e-19 Cerebrospinal P-tau181p levels; LUSC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg17279839 chr7:150038598 RARRES2 0.34 5.65 0.3 3.43e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs10911232 0.507 rs10797819 chr1:183006911 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.67e-24 Hypertriglyceridemia; LUSC cis rs9649465 0.561 rs609953 chr7:123422444 T/A cg03229431 chr7:123269106 ASB15 0.48 7.82 0.39 7.21e-14 Migraine; LUSC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg15921436 chr17:44337874 NA 0.75 11.33 0.53 2.08e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7089973 0.872 rs7072364 chr10:116620840 G/A cg23260525 chr10:116636907 FAM160B1 0.4 8.1 0.41 1.02e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7917772 0.582 rs4919663 chr10:104363293 T/C cg22532475 chr10:104410764 TRIM8 -0.25 -5.99 -0.31 5.4e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10170310 1.000 rs10803568 chr2:139290914 T/C cg10095539 chr2:139258744 SPOPL 0.32 5.76 0.3 1.89e-8 Response to antipsychotic treatment; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18344452 chr15:55790608 DYX1C1 0.52 7.54 0.38 4.62e-13 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs41271473 1.000 rs6701241 chr1:228868477 C/G cg16512390 chr1:228756714 NA 0.48 5.79 0.3 1.59e-8 Chronic lymphocytic leukemia; LUSC cis rs1950626 0.623 rs66722144 chr14:101457434 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.48 0.38 6.57e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs7647973 1.000 rs3870341 chr3:49584745 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.51 7.83 0.39 6.69e-14 Menarche (age at onset); LUSC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg16145915 chr7:1198662 ZFAND2A -0.44 -6.35 -0.33 7.05e-10 Bronchopulmonary dysplasia; LUSC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg22857025 chr5:266934 NA -1.17 -16.85 -0.68 1.53e-46 Breast cancer; LUSC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg25767906 chr1:53392781 SCP2 -0.48 -7.92 -0.4 3.52e-14 Monocyte count; LUSC cis rs3781663 0.581 rs10793018 chr11:70004396 G/A cg24276624 chr11:69982941 ANO1 -0.44 -6.77 -0.35 5.87e-11 Survival in rectal cancer; LUSC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg09267113 chr7:98030324 BAIAP2L1 0.41 6.24 0.32 1.34e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6424115 0.830 rs3003333 chr1:24194014 A/T cg10978503 chr1:24200527 CNR2 -0.51 -12.44 -0.56 1.95e-29 Immature fraction of reticulocytes; LUSC cis rs2067615 0.579 rs4964492 chr12:107222774 C/T cg19260189 chr12:106995001 RFX4 0.24 5.96 0.31 6.47e-9 Heart rate; LUSC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC trans rs11662586 0.517 rs7228070 chr18:77698967 C/T cg05926928 chr17:57297772 GDPD1 0.6 9.4 0.46 8.88e-19 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs12476592 0.602 rs2604613 chr2:63832776 G/A cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.68 11.62 0.54 1.93e-26 Menarche (age at onset); LUSC cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg16249355 chr17:76310516 NA 0.38 6.09 0.32 3.1e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs2404602 0.692 rs3110382 chr15:77148688 G/A cg22467129 chr15:76604101 ETFA 0.42 6.65 0.34 1.19e-10 Blood metabolite levels; LUSC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.09 -0.36 8.04e-12 Intelligence (multi-trait analysis); LUSC cis rs7178572 0.633 rs11854328 chr15:77840129 A/G cg22256960 chr15:77711686 NA -0.48 -7.04 -0.36 1.07e-11 Type 2 diabetes; LUSC cis rs9811920 0.809 rs35422475 chr3:99711545 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 5.8 0.3 1.58e-8 Axial length; LUSC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.56 -5.79 -0.3 1.66e-8 Cerebrospinal P-tau181p levels; LUSC cis rs9921222 0.509 rs3743883 chr16:404750 T/C cg12437481 chr16:420112 MRPL28 -0.38 -6.2 -0.32 1.68e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs9467160 0.871 rs7762593 chr6:24449417 G/A cg20631270 chr6:24437470 GPLD1 0.44 5.65 0.3 3.37e-8 Liver enzyme levels; LUSC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg09034736 chr1:150693464 HORMAD1 -0.45 -6.42 -0.33 4.63e-10 Melanoma; LUSC cis rs1322512 0.959 rs2623954 chr6:152966001 G/A cg03415253 chr6:152958462 SYNE1 -0.38 -5.68 -0.3 2.95e-8 Tonometry; LUSC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg17264618 chr3:40429014 ENTPD3 0.34 7.24 0.37 3.18e-12 Renal cell carcinoma; LUSC cis rs2901656 0.677 rs2269615 chr1:172415451 C/T cg03748243 chr1:172413542 C1orf105;PIGC 0.36 7.41 0.38 1.02e-12 Red cell distribution width;Platelet distribution width; LUSC cis rs3764021 0.870 rs2401394 chr12:9879426 G/A cg20894963 chr12:9885564 CLECL1 0.34 6.83 0.35 4.12e-11 Type 1 diabetes; LUSC cis rs9359856 0.564 rs72915946 chr6:90447924 C/T cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.43 -0.42 1.02e-15 Bipolar disorder; LUSC cis rs9311676 0.656 rs11130636 chr3:58380098 C/A cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs11603020 0.904 rs4926 chr11:57381989 G/A cg23127183 chr11:57508653 C11orf31 -0.47 -6.57 -0.34 1.95e-10 Blood protein levels; LUSC cis rs4242434 0.819 rs55776566 chr8:22469492 T/C cg03733263 chr8:22462867 KIAA1967 0.85 14.49 0.62 2.9e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.56 -7.16 -0.36 5.02e-12 Schizophrenia; LUSC cis rs611744 0.781 rs656406 chr8:109173843 G/A cg18478394 chr8:109455254 TTC35 0.43 6.5 0.33 2.98e-10 Dupuytren's disease; LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg02018176 chr4:1364513 KIAA1530 -0.72 -12.94 -0.58 2.63e-31 Longevity; LUSC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs614226 1.000 rs7174 chr12:121017171 A/G cg01236616 chr12:121019343 POP5 1.31 21.44 0.76 9.26e-65 Type 1 diabetes nephropathy; LUSC cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.21 -0.45 3.59e-18 Schizophrenia; LUSC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.18 -0.32 1.87e-9 Electroencephalogram traits; LUSC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC trans rs2727020 0.595 rs10466496 chr11:49501514 C/T cg15704280 chr7:45808275 SEPT13 -1.1 -22.17 -0.77 1.3e-67 Coronary artery disease; LUSC trans rs61931739 0.635 rs1486883 chr12:33908740 C/T cg13010199 chr12:38710504 ALG10B 0.4 6.07 0.32 3.52e-9 Morning vs. evening chronotype; LUSC cis rs3820928 0.845 rs13415319 chr2:227878936 G/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.32e-13 Pulmonary function; LUSC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg12311346 chr5:56204834 C5orf35 -0.98 -14.24 -0.61 2.81e-36 Initial pursuit acceleration; LUSC cis rs9325144 0.600 rs2171405 chr12:38741030 G/T cg26384229 chr12:38710491 ALG10B -0.6 -9.32 -0.45 1.69e-18 Morning vs. evening chronotype; LUSC cis rs2115630 0.691 rs61322921 chr15:85163638 T/C cg11189052 chr15:85197271 WDR73 -0.64 -9.86 -0.47 2.7e-20 P wave terminal force; LUSC cis rs3760982 0.585 rs8109812 chr19:44298494 C/A cg11993925 chr19:44307056 LYPD5 0.35 7.67 0.39 1.9e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs8017423 0.838 rs11845950 chr14:90723962 T/A cg04374321 chr14:90722782 PSMC1 0.76 12.13 0.55 2.61e-28 Mortality in heart failure; LUSC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg00343986 chr7:65444356 GUSB 0.44 6.8 0.35 4.95e-11 Aortic root size; LUSC cis rs72781680 1.000 rs12614452 chr2:24194608 C/T cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs2108225 0.872 rs2051955 chr7:107441154 C/T cg18560240 chr7:107437656 SLC26A3 -0.44 -6.65 -0.34 1.2e-10 Ulcerative colitis; LUSC cis rs1044826 0.642 rs186103 chr3:139211942 C/A cg15131784 chr3:139108705 COPB2 0.4 6.38 0.33 6.03e-10 Obesity-related traits; LUSC cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg04545296 chr12:48745243 ZNF641 -0.36 -6.68 -0.34 9.99e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs941408 0.515 rs4624312 chr19:2774460 T/C cg02580895 chr19:2754563 NA -0.45 -6.8 -0.35 4.82e-11 Total cholesterol levels; LUSC cis rs9359856 0.517 rs17506515 chr6:90507332 G/A cg13799429 chr6:90582589 CASP8AP2 -0.84 -8.33 -0.41 2.13e-15 Bipolar disorder; LUSC cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.93 0.31 7.75e-9 Rheumatoid arthritis; LUSC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg21963583 chr11:68658836 MRPL21 0.54 8.13 0.41 8.42e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg14004847 chr7:1930337 MAD1L1 -0.53 -8.07 -0.4 1.31e-14 Bipolar disorder and schizophrenia; LUSC cis rs977987 1.000 rs62060550 chr16:75502252 C/T cg03315344 chr16:75512273 CHST6 0.55 10.7 0.51 3.58e-23 Dupuytren's disease; LUSC cis rs17092148 1.000 rs6060040 chr20:33359054 G/C cg16810054 chr20:33298113 TP53INP2 -0.45 -6.77 -0.35 5.85e-11 Neuroticism; LUSC cis rs4660306 0.614 rs11211116 chr1:45930038 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.42 5.74 0.3 2.16e-8 Homocysteine levels; LUSC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg01616529 chr11:638424 DRD4 -0.35 -5.87 -0.31 1.07e-8 Systemic lupus erythematosus; LUSC cis rs9398803 0.965 rs4895807 chr6:126686513 C/G cg19875578 chr6:126661172 C6orf173 0.41 6.12 0.32 2.65e-9 Male-pattern baldness; LUSC cis rs9814567 0.762 rs13071253 chr3:134316653 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 11.96 0.55 1.09e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs57920188 0.584 rs12080562 chr1:4089697 C/A cg20703997 chr1:4087676 NA 0.53 7.79 0.39 8.57e-14 Interleukin-17 levels; LUSC cis rs10435719 0.902 rs4840599 chr8:11805380 C/T cg21775007 chr8:11205619 TDH -0.42 -5.99 -0.31 5.31e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs228769 0.653 rs2523162 chr17:42179281 A/G cg19774624 chr17:42201019 HDAC5 0.71 8.84 0.44 5.59e-17 Bone mineral density (hip);Bone mineral density (spine); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11327054 chr11:6502632 FXC1;ARFIP2 0.77 6.07 0.32 3.52e-9 Cognitive performance; LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg00149659 chr3:10157352 C3orf10 0.91 12.66 0.57 2.94e-30 Alzheimer's disease; LUSC cis rs2404602 0.647 rs11632765 chr15:76974261 A/T cg23625390 chr15:77176239 SCAPER 0.66 10.37 0.49 5.17e-22 Blood metabolite levels; LUSC cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg07061783 chr6:25882402 NA -0.38 -5.85 -0.3 1.19e-8 Blood metabolite levels; LUSC cis rs3812762 0.879 rs3844099 chr11:8808252 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.39 6.86 0.35 3.32e-11 Hypospadias; LUSC trans rs9886428 1.000 rs11203588 chr8:14116631 T/A cg19037007 chr20:741798 C20orf54 -0.39 -6.04 -0.31 4.02e-9 IgG glycosylation; LUSC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.98 0.31 5.84e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3540 0.533 rs937793 chr15:91053583 A/G cg22089800 chr15:90895588 ZNF774 -0.6 -8.55 -0.42 4.4e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6964587 0.872 rs57969083 chr7:91665627 A/T cg22709100 chr7:91322751 NA 0.38 5.68 0.3 2.99e-8 Breast cancer; LUSC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg22029157 chr1:209979665 IRF6 0.8 10.25 0.49 1.27e-21 Cleft lip with or without cleft palate; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg17178900 chr1:205818956 PM20D1 0.94 18.7 0.72 6.71e-54 Menarche (age at onset); LUSC cis rs11630290 0.566 rs4777395 chr15:64161693 T/G cg12036633 chr15:63758958 NA 0.54 6.92 0.35 2.3e-11 Iris characteristics; LUSC cis rs7727544 0.716 rs11949055 chr5:131576737 T/C cg14196790 chr5:131705035 SLC22A5 0.49 8.47 0.42 7.66e-16 Blood metabolite levels; LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg03579872 chr1:53393473 SCP2 -0.39 -5.77 -0.3 1.86e-8 Monocyte count; LUSC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg06484146 chr7:12443880 VWDE -0.67 -7.01 -0.36 1.36e-11 Coronary artery disease; LUSC cis rs4242434 0.927 rs11778693 chr8:22462852 T/C cg03733263 chr8:22462867 KIAA1967 1.0 18.56 0.71 2.51e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC trans rs2204008 0.837 rs11495548 chr12:38076756 C/T cg06521331 chr12:34319734 NA -0.39 -5.96 -0.31 6.28e-9 Bladder cancer; LUSC cis rs12474201 0.928 rs13025984 chr2:46938789 T/C cg06386533 chr2:46925753 SOCS5 0.78 11.76 0.54 6.04e-27 Height; LUSC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg15445000 chr17:37608096 MED1 -0.39 -6.63 -0.34 1.35e-10 Glomerular filtration rate (creatinine); LUSC cis rs9814567 0.679 rs1880379 chr3:134330612 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2239547 0.563 rs6445547 chr3:52908577 T/C cg11645453 chr3:52864694 ITIH4 0.52 11.2 0.52 6.19e-25 Schizophrenia; LUSC cis rs6546886 0.913 rs12713805 chr2:74243380 C/T cg14702570 chr2:74259524 NA -0.3 -5.65 -0.3 3.36e-8 Dialysis-related mortality; LUSC cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.96 0.7 5.97e-51 Chronic sinus infection; LUSC cis rs9487051 0.768 rs458740 chr6:109525527 C/T cg01475377 chr6:109611718 NA -0.35 -5.89 -0.31 9.21e-9 Reticulocyte fraction of red cells; LUSC cis rs1577917 0.740 rs2758845 chr6:86334848 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -9.47 -0.46 5.3e-19 Response to antipsychotic treatment; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26151740 chr19:54641525 CNOT3 0.62 6.13 0.32 2.48e-9 Cognitive performance; LUSC cis rs1395 1.000 rs1395 chr2:27424636 G/A cg23587288 chr2:27483067 SLC30A3 0.28 5.7 0.3 2.63e-8 Blood metabolite levels; LUSC cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.61 -0.34 1.53e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.43 0.62 5.05e-37 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs61931739 1.000 rs12298806 chr12:34036528 C/G cg06521331 chr12:34319734 NA 0.4 6.61 0.34 1.48e-10 Morning vs. evening chronotype; LUSC cis rs66716358 0.744 rs11037943 chr11:44317445 A/G cg16977035 chr11:44330474 ALX4 0.36 6.02 0.31 4.69e-9 Monobrow; LUSC cis rs360798 0.532 rs12713468 chr2:62983213 G/A cg17519650 chr2:63277830 OTX1 -0.52 -7.22 -0.37 3.63e-12 Coronary artery disease; LUSC cis rs7577696 0.785 rs3769602 chr2:32381829 G/A cg02381751 chr2:32503542 YIPF4 -0.44 -6.27 -0.32 1.09e-9 Inflammatory biomarkers; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg07092213 chr7:1199455 ZFAND2A -0.67 -11.16 -0.52 8.75e-25 Longevity;Endometriosis; LUSC cis rs1451375 0.617 rs10271341 chr7:50591583 A/C cg18232548 chr7:50535776 DDC 0.56 7.79 0.39 8.27e-14 Malaria; LUSC cis rs9814567 1.000 rs9876658 chr3:134179453 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.77 12.79 0.57 9.09e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7759001 0.857 rs766092 chr6:27368031 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.84e-8 Glomerular filtration rate (creatinine); LUSC cis rs870825 0.616 rs7700216 chr4:185648510 G/T cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs7681440 0.626 rs6812593 chr4:90817991 C/T cg20003494 chr4:90757398 SNCA -0.36 -5.87 -0.31 1.06e-8 Dementia with Lewy bodies; LUSC cis rs1113500 0.933 rs10785833 chr1:108639082 A/G cg11967332 chr1:108735228 SLC25A24 0.39 5.94 0.31 7.31e-9 Growth-regulated protein alpha levels; LUSC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg02423579 chr7:2872169 GNA12 -0.47 -6.76 -0.35 6.16e-11 Height; LUSC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg05872129 chr22:39784769 NA -0.62 -11.68 -0.54 1.17e-26 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.65 13.96 0.61 3.42e-35 Monocyte percentage of white cells; LUSC cis rs1788820 0.917 rs1652349 chr18:21142734 A/T cg14672496 chr18:21087552 C18orf8 0.42 6.79 0.35 5.02e-11 Body mass index; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg24846343 chr22:24311635 DDTL 0.76 17.31 0.69 2.35e-48 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg03929089 chr4:120376271 NA -0.95 -16.34 -0.67 1.59e-44 Height; LUSC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg02228675 chr17:40259724 DHX58 0.46 6.54 0.34 2.32e-10 Fibrinogen levels; LUSC cis rs17270561 0.525 rs10484432 chr6:26008876 G/A cg16482183 chr6:26056742 HIST1H1C 1.06 13.62 0.6 6.47e-34 Iron status biomarkers; LUSC cis rs9815354 0.761 rs73079307 chr3:41862273 A/C cg03022575 chr3:42003672 ULK4 0.84 8.78 0.43 8.69e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs8114671 0.742 rs6058161 chr20:33620026 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -5.76 -0.3 1.92e-8 Height; LUSC cis rs16866061 0.888 rs6748341 chr2:225377574 C/G cg12698349 chr2:225449008 CUL3 0.85 13.37 0.59 5.85e-33 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg06634786 chr22:41940651 POLR3H -0.55 -6.39 -0.33 5.42e-10 Vitiligo; LUSC cis rs9487051 0.735 rs351745 chr6:109529169 C/T cg12927641 chr6:109611667 NA 0.35 5.74 0.3 2.09e-8 Reticulocyte fraction of red cells; LUSC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg13607699 chr17:42295918 UBTF -0.69 -11.27 -0.52 3.61e-25 Total body bone mineral density; LUSC cis rs9788682 0.747 rs7174190 chr15:78763617 C/T cg24631222 chr15:78858424 CHRNA5 0.64 8.51 0.42 5.9e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg15649852 chr7:65879115 NA 0.39 5.72 0.3 2.41e-8 Aortic root size; LUSC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs10754283 0.967 rs10801760 chr1:90113824 G/A cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs41308713 0.786 rs8116471 chr20:37034694 A/C cg09132763 chr20:37064059 LOC388796;SNORA71D 1.0 6.87 0.35 3.1e-11 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC trans rs1493916 0.748 rs1389535 chr18:31310416 A/G cg27147174 chr7:100797783 AP1S1 0.58 9.15 0.45 5.86e-18 Life satisfaction; LUSC cis rs314370 0.951 rs12666989 chr7:100486754 G/C cg10426581 chr7:100472382 SRRT 0.86 12.48 0.56 1.36e-29 Resting heart rate; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg20849893 chr7:64541193 NA 0.45 6.45 0.33 4.01e-10 Calcium levels; LUSC cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg12011299 chr4:100065546 ADH4 0.71 10.75 0.51 2.33e-23 Alcohol dependence; LUSC cis rs7106204 0.534 rs74650605 chr11:24253414 T/C ch.11.24196551F chr11:24239977 NA 0.72 6.09 0.32 3.05e-9 Response to Homoharringtonine (cytotoxicity); LUSC trans rs12637928 0.560 rs11715486 chr3:110209208 G/T cg17371621 chr15:61264283 RORA 0.36 5.96 0.31 6.29e-9 Neuroticism; LUSC cis rs11122272 0.677 rs2808615 chr1:231550171 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.7 11.03 0.52 2.5e-24 Hemoglobin concentration; LUSC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg06112835 chr11:68658793 MRPL21 0.49 7.44 0.38 8.85e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg13010199 chr12:38710504 ALG10B 0.66 9.98 0.48 1.04e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg16230307 chr14:35515116 FAM177A1 0.78 10.0 0.48 8.96e-21 Psoriasis; LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg18538332 chr22:24372958 LOC391322 0.37 6.66 0.34 1.13e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6582630 0.572 rs7315897 chr12:38449081 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.48 -0.33 3.3e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7954584 0.813 rs12827200 chr12:122451278 G/A cg21016266 chr12:122356598 WDR66 0.56 8.3 0.41 2.61e-15 Mean corpuscular volume; LUSC trans rs7647973 0.593 rs7620848 chr3:49828021 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.6 7.1 0.36 7.44e-12 Menarche (age at onset); LUSC cis rs858239 0.601 rs764533 chr7:23153875 C/T cg23682824 chr7:23144976 KLHL7 0.4 5.78 0.3 1.74e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg05084668 chr3:125655381 ALG1L -0.47 -6.62 -0.34 1.45e-10 Blood pressure (smoking interaction); LUSC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg02574844 chr11:5959923 NA -0.42 -5.92 -0.31 7.96e-9 DNA methylation (variation); LUSC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg12667521 chr19:29218732 NA -0.56 -6.86 -0.35 3.3e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg06238570 chr21:40685208 BRWD1 -0.63 -10.39 -0.49 4.34e-22 Cognitive function; LUSC cis rs2637266 0.783 rs2395434 chr10:78476161 T/C cg18941641 chr10:78392320 NA 0.34 6.22 0.32 1.52e-9 Pulmonary function; LUSC cis rs79349575 0.783 rs12602746 chr17:47031741 A/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC cis rs9788682 0.747 rs2568488 chr15:78736593 T/A cg24631222 chr15:78858424 CHRNA5 -0.67 -8.86 -0.44 4.69e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg06627557 chr7:32535165 LSM5;AVL9 -1.06 -20.44 -0.75 8.12e-61 Cognitive ability; LUSC cis rs2046867 0.818 rs6789061 chr3:72888690 C/T cg25664220 chr3:72788482 NA -0.66 -10.66 -0.5 5.14e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg19592336 chr6:28129416 ZNF389 0.5 6.57 0.34 1.94e-10 Parkinson's disease; LUSC cis rs2070433 0.539 rs721131 chr21:47957767 T/C cg12379764 chr21:47803548 PCNT 0.79 12.05 0.55 5.1e-28 Lymphocyte counts; LUSC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.58 7.77 0.39 9.64e-14 Lung function (FEV1/FVC); LUSC cis rs11958404 0.932 rs72816571 chr5:157429759 C/T cg05962755 chr5:157440814 NA 0.54 6.34 0.33 7.29e-10 IgG glycosylation; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg00166722 chr3:10149974 C3orf24 0.61 8.47 0.42 7.9e-16 Alzheimer's disease; LUSC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg03806693 chr22:41940476 POLR3H 0.99 14.17 0.61 5.16e-36 Vitiligo; LUSC cis rs7824557 0.628 rs7820301 chr8:11228672 G/A cg21775007 chr8:11205619 TDH 0.74 12.45 0.56 1.8e-29 Retinal vascular caliber; LUSC trans rs11098499 0.644 rs2389880 chr4:120559870 T/A cg25214090 chr10:38739885 LOC399744 0.44 6.74 0.35 7.16e-11 Corneal astigmatism; LUSC cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 9.85 0.47 3.02e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs886126 0.950 rs6490025 chr12:111691081 T/C cg10833066 chr12:111807467 FAM109A 0.4 6.09 0.32 3.06e-9 Coronary heart disease; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg27535305 chr1:53392650 SCP2 0.53 10.2 0.49 1.84e-21 Monocyte count; LUSC cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg08917208 chr2:24149416 ATAD2B 0.53 5.97 0.31 6e-9 Lymphocyte counts; LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18595196 chr3:52726726 GNL3;SNORD69 -0.29 -5.65 -0.3 3.46e-8 Bipolar disorder; LUSC cis rs34172651 0.917 rs200532 chr16:24756148 C/T cg06028605 chr16:24865363 SLC5A11 -0.47 -8.49 -0.42 6.75e-16 Intelligence (multi-trait analysis); LUSC cis rs3008870 0.755 rs1121824 chr1:67475616 C/A cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.26 0.56 8.64e-29 Lymphocyte percentage of white cells; LUSC cis rs2439831 1.000 rs7173487 chr15:43750239 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.94 10.54 0.5 1.29e-22 Lung cancer in ever smokers; LUSC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg19748678 chr4:122722346 EXOSC9 0.69 10.55 0.5 1.22e-22 Type 2 diabetes; LUSC cis rs7683537 0.554 rs55830081 chr4:185666477 A/C cg04058563 chr4:185651563 MLF1IP 0.77 11.02 0.52 2.69e-24 Systemic lupus erythematosus; LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg13395646 chr4:1353034 KIAA1530 -0.66 -11.08 -0.52 1.67e-24 Longevity; LUSC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg24250549 chr1:154909240 PMVK 0.65 10.56 0.5 1.15e-22 Prostate cancer; LUSC trans rs7819412 0.875 rs6981523 chr8:11061792 C/T cg15556689 chr8:8085844 FLJ10661 -0.59 -8.98 -0.44 2.06e-17 Triglycerides; LUSC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.08 -0.4 1.19e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg08085267 chr17:45401833 C17orf57 0.44 6.68 0.34 1.01e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs35110281 0.805 rs8131005 chr21:45041954 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.54 0.46 3.12e-19 Mean corpuscular volume; LUSC cis rs7937890 1.000 rs2970334 chr11:14329355 C/T cg19336497 chr11:14380999 RRAS2 0.45 8.13 0.41 8.49e-15 Mitochondrial DNA levels; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg11843238 chr5:131593191 PDLIM4 -0.49 -8.29 -0.41 2.85e-15 Acylcarnitine levels; LUSC cis rs9322193 0.923 rs4870052 chr6:150161114 G/A cg04369109 chr6:150039330 LATS1 -0.58 -8.31 -0.41 2.44e-15 Lung cancer; LUSC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg04398451 chr17:18023971 MYO15A 0.45 7.03 0.36 1.16e-11 Total body bone mineral density; LUSC cis rs763121 0.853 rs5757162 chr22:38993370 C/T cg14440974 chr22:39074834 NA -0.37 -6.22 -0.32 1.48e-9 Menopause (age at onset); LUSC cis rs7178572 0.568 rs11632941 chr15:77533888 A/G cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg06092702 chr1:163392909 NA -0.46 -7.56 -0.38 3.91e-13 Motion sickness; LUSC cis rs4808199 0.895 rs2163805 chr19:19575945 G/A cg03709012 chr19:19516395 GATAD2A 1.1 14.56 0.62 1.57e-37 Nonalcoholic fatty liver disease; LUSC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg19468946 chr17:37922297 IKZF3 -0.39 -6.15 -0.32 2.18e-9 Self-reported allergy; LUSC cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg05347473 chr6:146136440 FBXO30 0.41 6.89 0.35 2.73e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4478858 0.746 rs6703593 chr1:31689284 A/C cg00250761 chr1:31883323 NA 0.36 9.36 0.46 1.18e-18 Alcohol dependence; LUSC cis rs7572644 0.782 rs1870325 chr2:28144067 G/A cg27432699 chr2:27873401 GPN1 -0.53 -6.91 -0.35 2.45e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7927592 0.513 rs901823 chr11:68205578 T/C cg01657329 chr11:68192670 LRP5 -0.5 -7.85 -0.39 5.64e-14 Total body bone mineral density; LUSC cis rs2230307 0.505 rs571579 chr1:100617372 G/A cg24955406 chr1:100503596 HIAT1 -0.64 -6.95 -0.36 1.88e-11 Carotid intima media thickness; LUSC cis rs9905704 0.801 rs302847 chr17:56687481 C/T cg12560992 chr17:57184187 TRIM37 0.61 8.78 0.43 8.42e-17 Testicular germ cell tumor; LUSC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7264396 0.635 rs3827030 chr20:34474947 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.59 8.62 0.43 2.78e-16 Total cholesterol levels; LUSC cis rs713587 0.935 rs4430895 chr2:25161386 C/T cg01884057 chr2:25150051 NA 0.44 10.01 0.48 8.36e-21 Body mass index in non-asthmatics; LUSC cis rs4720118 0.875 rs3884597 chr7:33385262 G/T cg22798885 chr7:33102694 NT5C3 0.44 6.06 0.31 3.71e-9 Leprosy; LUSC cis rs4595586 0.545 rs11609541 chr12:39378331 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs2439831 0.867 rs933941 chr15:43632226 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.85 8.89 0.44 3.87e-17 Lung cancer in ever smokers; LUSC cis rs477692 1.000 rs508303 chr10:131424996 A/T cg05714579 chr10:131428358 MGMT -0.5 -7.65 -0.39 2.22e-13 Response to temozolomide; LUSC cis rs72781680 0.898 rs7563564 chr2:23993404 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs1372520 0.873 rs983361 chr4:90761944 T/G cg01966878 chr4:90757139 SNCA -0.42 -5.86 -0.31 1.12e-8 Neuroticism; LUSC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg09365446 chr1:150670422 GOLPH3L 0.47 6.78 0.35 5.31e-11 Melanoma; LUSC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg21466736 chr12:48725269 NA 0.3 5.74 0.3 2.14e-8 Glycated hemoglobin levels; LUSC cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg24692254 chr21:30365293 RNF160 0.92 19.02 0.72 3.51e-55 Dental caries; LUSC cis rs11105298 0.891 rs10858851 chr12:89830870 C/T cg00757033 chr12:89920650 WDR51B 0.58 9.42 0.46 7.55e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Bladder cancer; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.06e-17 Prudent dietary pattern; LUSC trans rs6598955 0.671 rs12116908 chr1:26587918 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs7829975 0.573 rs7842359 chr8:8797078 T/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.85 -0.35 3.59e-11 Mood instability; LUSC cis rs3008870 0.755 rs1024230 chr1:67512920 A/C cg02640540 chr1:67518911 SLC35D1 0.55 7.83 0.39 6.41e-14 Lymphocyte percentage of white cells; LUSC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.85 -0.63 1.22e-38 Total body bone mineral density; LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10751667 0.961 rs10794358 chr11:985547 C/T cg06064525 chr11:970664 AP2A2 -0.36 -7.07 -0.36 8.88e-12 Alzheimer's disease (late onset); LUSC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.22 0.41 4.41e-15 Electroencephalogram traits; LUSC cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg24642439 chr20:33292090 TP53INP2 0.5 7.43 0.38 8.94e-13 Height; LUSC cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.647 rs55778276 chr15:77136590 T/A cg23625390 chr15:77176239 SCAPER -0.66 -9.91 -0.48 1.87e-20 Blood metabolite levels; LUSC cis rs1728785 1.000 rs1645981 chr16:68571648 T/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.51 -6.84 -0.35 3.68e-11 Tonsillectomy; LUSC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg14019146 chr3:50243930 SLC38A3 -0.32 -7.01 -0.36 1.36e-11 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.924 rs11213968 chr11:111527629 G/C cg19812747 chr11:111475976 SIK2 -0.48 -6.83 -0.35 3.94e-11 Primary sclerosing cholangitis; LUSC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg06850241 chr22:41845214 NA 0.31 5.8 0.3 1.56e-8 Vitiligo; LUSC trans rs4596713 0.538 rs7048095 chr9:71745663 G/A cg25283916 chr1:242222868 NA -0.29 -6.04 -0.31 4.19e-9 Headache; LUSC cis rs7818345 1.000 rs7833166 chr8:19294634 C/T cg11303988 chr8:19266685 CSGALNACT1 0.38 7.19 0.37 4.24e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs189798 0.738 rs330908 chr8:8995166 A/G cg06636001 chr8:8085503 FLJ10661 0.45 6.43 0.33 4.39e-10 Myopia (pathological); LUSC trans rs2204008 0.720 rs11170774 chr12:38021722 C/T cg06521331 chr12:34319734 NA 0.39 6.18 0.32 1.82e-9 Bladder cancer; LUSC cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.53 -0.34 2.52e-10 Colorectal cancer; LUSC cis rs7582720 1.000 rs72926786 chr2:203816494 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1267303 0.537 rs59935547 chr1:47001423 A/G cg25110126 chr1:46999211 NA 0.72 10.39 0.49 4.37e-22 Monobrow; LUSC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.37 -0.37 1.38e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7804356 0.906 rs12532796 chr7:26854828 A/G cg03456212 chr7:26904342 SKAP2 -0.54 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC trans rs6555855 0.909 rs6896194 chr5:168721048 A/C cg19626044 chr1:243138527 NA -0.5 -6.05 -0.31 3.96e-9 Menarche (age at onset); LUSC cis rs9462027 0.606 rs2814979 chr6:34578425 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.01 -0.31 4.88e-9 Systemic lupus erythematosus; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg17747171 chr20:2633605 NOP56;SNORD110 0.43 6.02 0.31 4.47e-9 Mosquito bite size; LUSC cis rs7582720 1.000 rs72934505 chr2:203916487 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2073300 1.000 rs6137976 chr20:23463241 C/T cg09953122 chr20:23471693 CST8 -0.88 -7.54 -0.38 4.52e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs11098499 0.863 rs7657849 chr4:120455494 T/C cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs2377585 0.653 rs7976729 chr12:8848685 A/G cg03761649 chr12:8850719 RIMKLB 0.47 6.31 0.33 9.04e-10 Reticulocyte fraction of red cells; LUSC cis rs3760982 1.000 rs3760982 chr19:44286513 A/G cg11993925 chr19:44307056 LYPD5 0.29 6.32 0.33 8.28e-10 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs61931739 0.500 rs7303318 chr12:34467789 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.26 0.45 2.59e-18 Morning vs. evening chronotype; LUSC cis rs6964587 0.967 rs10231496 chr7:91741132 T/C cg17063962 chr7:91808500 NA 0.56 8.97 0.44 2.11e-17 Breast cancer; LUSC cis rs6545883 0.929 rs3821222 chr2:61713526 C/G cg15711740 chr2:61764176 XPO1 -0.44 -6.84 -0.35 3.72e-11 Tuberculosis; LUSC cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.46 -5.77 -0.3 1.8e-8 Schizophrenia; LUSC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg17143192 chr8:8559678 CLDN23 0.63 9.13 0.45 6.91e-18 Obesity-related traits; LUSC cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg21573476 chr21:45109991 RRP1B -0.43 -7.14 -0.36 5.96e-12 Mean corpuscular volume; LUSC cis rs12542260 0.871 rs4128469 chr8:125479475 C/T cg27038428 chr8:125485867 RNF139 0.33 6.56 0.34 2.11e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg23093090 chr10:104574429 C10orf26 -0.37 -7.07 -0.36 9.07e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12529083 chr12:13197360 KIAA1467 -0.43 -6.41 -0.33 4.88e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7100689 0.754 rs1934695 chr10:82125230 T/C cg00277334 chr10:82204260 NA -0.49 -6.68 -0.34 9.81e-11 Post bronchodilator FEV1; LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7903847 0.619 rs76094900 chr10:99158164 G/A cg20016023 chr10:99160130 RRP12 -0.33 -8.1 -0.41 1.01e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs12477438 0.765 rs28648058 chr2:99696417 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -7.91 -0.4 3.79e-14 Chronic sinus infection; LUSC cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -5.96 -0.31 6.43e-9 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26486377 chr16:2318312 RNPS1 -0.47 -6.0 -0.31 5.28e-9 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg25456477 chr12:86230367 RASSF9 0.41 7.31 0.37 2.04e-12 Major depressive disorder; LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg20503657 chr10:835505 NA 0.78 9.25 0.45 2.78e-18 Eosinophil percentage of granulocytes; LUSC cis rs3096299 0.606 rs2965960 chr16:89541795 G/A cg06640241 chr16:89574553 SPG7 0.68 9.27 0.45 2.35e-18 Multiple myeloma (IgH translocation); LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.51 0.34 2.69e-10 Menopause (age at onset); LUSC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg27532560 chr4:187881888 NA -0.39 -6.41 -0.33 5.1e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs8077889 1.000 rs4793035 chr17:41887753 C/T cg26893861 chr17:41843967 DUSP3 1.0 15.11 0.64 1.15e-39 Triglycerides; LUSC cis rs2427308 0.607 rs1741635 chr20:60938197 C/G cg06026331 chr20:60912101 LAMA5 -0.59 -7.02 -0.36 1.26e-11 Colorectal cancer; LUSC cis rs977987 0.778 rs4888400 chr16:75425596 G/C cg03315344 chr16:75512273 CHST6 0.48 9.06 0.44 1.1e-17 Dupuytren's disease; LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.61e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs867529 0.620 rs335121 chr2:89084327 G/C cg26627705 chr2:89060884 NA 0.42 5.81 0.3 1.47e-8 Height; LUSC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.64e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.57 0.34 1.94e-10 Menopause (age at onset); LUSC cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg24130564 chr14:104152367 KLC1 -0.39 -5.64 -0.3 3.54e-8 Body mass index; LUSC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg18477163 chr1:228402036 OBSCN -0.58 -10.84 -0.51 1.18e-23 Diastolic blood pressure; LUSC cis rs57590327 0.503 rs13066091 chr3:81589912 T/C cg07356753 chr3:81810745 GBE1 -0.5 -6.7 -0.34 9.07e-11 Extraversion; LUSC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg09033563 chr22:24373618 LOC391322 -0.6 -9.32 -0.45 1.67e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg18350739 chr11:68623251 NA -0.36 -6.23 -0.32 1.42e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg26384229 chr12:38710491 ALG10B 0.94 17.84 0.7 1.77e-50 Heart rate; LUSC cis rs847577 0.677 rs951988 chr7:97762474 C/G cg24562669 chr7:97807699 LMTK2 -0.39 -6.39 -0.33 5.62e-10 Breast cancer; LUSC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.58 0.34 1.84e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs2637266 0.597 rs846615 chr10:78548489 A/G cg18941641 chr10:78392320 NA -0.4 -7.29 -0.37 2.25e-12 Pulmonary function; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg13871565 chr1:244973565 NA -0.34 -6.36 -0.33 6.71e-10 N-glycan levels; LUSC cis rs1215050 0.765 rs1530905 chr4:98805705 A/G cg05340658 chr4:99064831 C4orf37 0.44 7.0 0.36 1.41e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.71 0.3 2.54e-8 Menopause (age at onset); LUSC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.86 0.35 3.39e-11 Intelligence (multi-trait analysis); LUSC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg07414643 chr4:187882934 NA 0.55 10.53 0.5 1.41e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs11264799 0.539 rs2779160 chr1:157550950 C/T cg18268488 chr1:157545234 FCRL4 0.38 7.45 0.38 7.86e-13 IgA nephropathy; LUSC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg22875332 chr1:76189707 ACADM -0.68 -9.42 -0.46 7.91e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1997103 1.000 rs6976824 chr7:55396115 A/C cg17469321 chr7:55412551 NA 0.57 9.53 0.46 3.32e-19 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs4664308 1.000 rs17831191 chr2:160911332 T/C cg03641300 chr2:160917029 PLA2R1 -0.67 -11.33 -0.53 2.16e-25 Idiopathic membranous nephropathy; LUSC cis rs7607369 0.637 rs3731866 chr2:219288899 C/T cg02176678 chr2:219576539 TTLL4 -0.72 -12.14 -0.55 2.44e-28 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC cis rs17253792 0.822 rs28392709 chr14:56093685 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg17628894 chr11:804452 LRDD 0.42 9.46 0.46 5.61e-19 Breast cancer; LUSC trans rs1949829 0.826 rs6592924 chr7:51535246 C/G cg20941110 chr15:83953819 BNC1 0.55 6.01 0.31 4.98e-9 Wegener's granulomatosis; LUSC trans rs1814175 0.717 rs11040450 chr11:49650638 G/A cg03929089 chr4:120376271 NA -0.99 -17.56 -0.69 2.27e-49 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00787537 chr1:211307839 KCNH1 -0.42 -6.12 -0.32 2.65e-9 Hepatitis; LUSC cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.96 -0.4 2.67e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg06238570 chr21:40685208 BRWD1 -0.49 -7.61 -0.38 2.77e-13 Cognitive function; LUSC trans rs2370759 0.945 rs3740237 chr10:32557592 G/C cg07829597 chr10:77161705 C10orf41;ZNF503 0.64 5.98 0.31 5.62e-9 Sexual dysfunction (female); LUSC trans rs11098499 0.754 rs12711071 chr4:120240934 A/G cg25214090 chr10:38739885 LOC399744 0.4 6.14 0.32 2.39e-9 Corneal astigmatism; LUSC cis rs6733011 0.628 rs6542838 chr2:99452458 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.84 -0.3 1.25e-8 Bipolar disorder; LUSC cis rs7572733 0.534 rs1401091 chr2:198790423 T/G cg00792783 chr2:198669748 PLCL1 -0.44 -5.86 -0.31 1.13e-8 Dermatomyositis; LUSC cis rs760794 0.533 rs2206034 chr6:19796863 C/T cg02404759 chr6:19790362 NA -0.38 -5.97 -0.31 6.12e-9 Endometriosis; LUSC cis rs6690583 0.562 rs6665436 chr1:85532894 T/C cg11262906 chr1:85462892 MCOLN2 0.72 6.32 0.33 8.57e-10 Serum sulfate level; LUSC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg04800585 chr6:26043546 HIST1H2BB 0.37 5.65 0.3 3.35e-8 Intelligence (multi-trait analysis); LUSC cis rs9952991 0.941 rs1893217 chr18:12809340 A/G cg23544223 chr18:12777786 NA -0.54 -5.65 -0.3 3.47e-8 Inflammatory skin disease; LUSC cis rs72772090 0.539 rs72773942 chr5:96123366 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.96 -0.36 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10465746 0.935 rs11163878 chr1:84442654 G/A cg10977910 chr1:84465055 TTLL7 0.42 6.23 0.32 1.42e-9 Obesity-related traits; LUSC cis rs6547741 1.000 rs11127071 chr2:27838058 C/A cg12559939 chr2:27858050 GPN1 0.41 6.48 0.33 3.28e-10 Oral cavity cancer; LUSC cis rs1018697 1.000 rs7092346 chr10:104559764 A/G cg04362960 chr10:104952993 NT5C2 0.47 6.51 0.34 2.82e-10 Colorectal adenoma (advanced); LUSC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg22857025 chr5:266934 NA -1.16 -16.29 -0.67 2.65e-44 Breast cancer; LUSC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg02772935 chr3:125709198 NA -0.48 -5.78 -0.3 1.7e-8 Blood pressure (smoking interaction); LUSC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg14784868 chr12:69753453 YEATS4 0.82 13.97 0.61 2.99e-35 Blood protein levels; LUSC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg24060327 chr5:131705240 SLC22A5 -0.52 -8.71 -0.43 1.45e-16 Breast cancer; LUSC cis rs7539409 0.915 rs4001467 chr1:84275858 A/T cg10977910 chr1:84465055 TTLL7 -0.62 -6.24 -0.32 1.32e-9 Alzheimer's disease; LUSC cis rs2806561 0.765 rs4333826 chr1:23517514 C/T cg12483005 chr1:23474871 LUZP1 0.41 6.5 0.34 2.89e-10 Height; LUSC cis rs7113850 0.541 rs77054343 chr11:24215636 A/G ch.11.24196551F chr11:24239977 NA 0.95 7.17 0.37 4.71e-12 Bone fracture in osteoporosis; LUSC cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg13736514 chr6:26305472 NA -0.48 -9.52 -0.46 3.66e-19 Educational attainment; LUSC cis rs1448094 0.842 rs10863155 chr12:86446416 T/C cg02569458 chr12:86230093 RASSF9 -0.36 -5.68 -0.3 2.93e-8 Major depressive disorder; LUSC cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.55 -0.34 2.14e-10 Monocyte percentage of white cells; LUSC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg08048268 chr3:133502702 NA -0.52 -10.48 -0.5 2.04e-22 Iron status biomarkers; LUSC cis rs2282802 0.635 rs199152 chr5:139539235 C/T cg26211634 chr5:139558579 C5orf32 -0.39 -7.44 -0.38 8.33e-13 Intelligence (multi-trait analysis); LUSC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg20243544 chr17:37824526 PNMT 0.49 6.88 0.35 2.98e-11 Asthma; LUSC cis rs17685 0.753 rs55812043 chr7:75747241 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.94 -0.4 3.06e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg00579200 chr11:133705235 NA -0.39 -5.67 -0.3 3.03e-8 Childhood ear infection; LUSC cis rs7677751 0.806 rs1800810 chr4:55094031 C/G cg17187183 chr4:55093834 PDGFRA 0.39 5.89 0.31 9.61e-9 Corneal astigmatism; LUSC cis rs8060686 0.641 rs8064114 chr16:68240185 G/A cg05110241 chr16:68378359 PRMT7 -0.52 -6.12 -0.32 2.57e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9304742 0.962 rs12459008 chr19:53454789 A/T cg09503522 chr19:53445286 ZNF321 0.37 5.87 0.31 1.07e-8 Psoriasis; LUSC trans rs3960554 0.800 rs80002395 chr7:75814902 C/T cg19862616 chr7:65841803 NCRNA00174 0.88 9.96 0.48 1.28e-20 Eotaxin levels; LUSC cis rs6546886 0.957 rs4364046 chr2:74256305 A/G cg14702570 chr2:74259524 NA 0.32 6.15 0.32 2.15e-9 Dialysis-related mortality; LUSC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg08847533 chr14:75593920 NEK9 -0.84 -15.37 -0.64 1.13e-40 Height; LUSC cis rs7618501 1.000 rs7618501 chr3:49772647 A/G cg12257692 chr3:49977190 RBM6 -0.21 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); LUSC cis rs11792861 0.505 rs12377869 chr9:111907803 C/A cg13535736 chr9:111863775 C9orf5 -0.33 -5.74 -0.3 2.11e-8 Menarche (age at onset); LUSC cis rs11051970 0.636 rs1128591 chr12:32569351 T/C cg02745156 chr12:32552066 NA 0.39 7.09 0.36 8.27e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3733631 1.000 rs3775971 chr4:104641920 C/T cg24090629 chr4:104641072 TACR3 0.48 6.08 0.32 3.37e-9 Menarche (age at onset); LUSC trans rs2727020 0.754 rs1851990 chr11:49413336 C/T cg15704280 chr7:45808275 SEPT13 -0.92 -14.23 -0.61 3.04e-36 Coronary artery disease; LUSC cis rs7929679 0.551 rs11032849 chr11:34785740 G/A cg06937548 chr11:34938143 PDHX;APIP 0.4 5.9 0.31 8.92e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs11642862 1.000 rs75231191 chr16:30788601 C/T cg02466173 chr16:30829666 NA -0.66 -7.08 -0.36 8.57e-12 Tonsillectomy; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg21782813 chr7:2030301 MAD1L1 0.48 8.12 0.41 9.21e-15 Bipolar disorder and schizophrenia; LUSC trans rs561341 1.000 rs550923 chr17:30327013 G/C cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs7954584 0.813 rs12827200 chr12:122451278 G/A cg21171335 chr12:122356390 WDR66 0.56 8.32 0.41 2.22e-15 Mean corpuscular volume; LUSC cis rs4631830 0.720 rs12763717 chr10:51500874 C/G cg16070123 chr10:51489643 NA 0.57 9.35 0.46 1.29e-18 Prostate-specific antigen levels; LUSC cis rs7582180 0.663 rs6542930 chr2:100944383 T/A cg08017756 chr2:100939284 LONRF2 -0.44 -8.24 -0.41 3.89e-15 Intelligence (multi-trait analysis); LUSC cis rs4343996 0.967 rs10268249 chr7:3347074 C/T cg21248987 chr7:3385318 SDK1 0.4 6.75 0.35 6.45e-11 Motion sickness; LUSC cis rs11648785 0.747 rs3743826 chr16:90094214 C/T cg16611967 chr16:90144006 NA 0.44 5.86 0.31 1.11e-8 Tanning; LUSC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg22166914 chr1:53195759 ZYG11B 0.71 12.06 0.55 4.79e-28 Monocyte count; LUSC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg03929089 chr4:120376271 NA -0.5 -7.08 -0.36 8.68e-12 Coronary artery disease; LUSC cis rs7210086 0.808 rs4331375 chr17:70640082 A/G cg04206342 chr17:70636940 NA -0.4 -6.67 -0.34 1.09e-10 Ulcerative colitis; LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg12432903 chr7:1882776 MAD1L1 -0.38 -5.95 -0.31 6.69e-9 Bipolar disorder and schizophrenia; LUSC cis rs2324229 0.927 rs1180196 chr6:83960006 A/G cg08257003 chr6:84140564 ME1 0.3 7.06 0.36 9.86e-12 Platelet-derived growth factor BB levels; LUSC cis rs11098499 0.754 rs12506610 chr4:120241659 T/C cg24375607 chr4:120327624 NA 0.76 12.23 0.56 1.14e-28 Corneal astigmatism; LUSC cis rs9837602 0.938 rs28503408 chr3:99794842 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.06 -0.31 3.72e-9 Breast cancer; LUSC cis rs11122272 0.735 rs2572252 chr1:231513653 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg01657329 chr11:68192670 LRP5 -0.44 -6.54 -0.34 2.35e-10 Total body bone mineral density; LUSC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg24296786 chr1:45957014 TESK2 0.52 8.02 0.4 1.83e-14 High light scatter reticulocyte count; LUSC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg23590916 chr17:43697445 MGC57346 0.49 6.63 0.34 1.38e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg10360139 chr7:1886902 MAD1L1 -0.4 -6.01 -0.31 4.85e-9 Bipolar disorder and schizophrenia; LUSC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs4727027 0.704 rs2888600 chr7:148908562 C/T cg14690467 chr7:148917905 ZNF282 -0.26 -5.69 -0.3 2.71e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg03289416 chr15:75166202 SCAMP2 -0.47 -7.41 -0.38 1.05e-12 Breast cancer; LUSC cis rs13256369 0.851 rs13266562 chr8:8564065 T/C cg00074818 chr8:8560427 CLDN23 0.59 9.95 0.48 1.32e-20 Obesity-related traits; LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg24813613 chr7:1882135 MAD1L1 -0.43 -7.22 -0.37 3.59e-12 Bipolar disorder and schizophrenia; LUSC cis rs17685 0.712 rs2158867 chr7:75815141 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.48 -7.21 -0.37 3.74e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg03806693 chr22:41940476 POLR3H -0.96 -13.11 -0.58 5.93e-32 Vitiligo; LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.37 0.53 1.49e-25 Prudent dietary pattern; LUSC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg17330251 chr7:94953956 PON1 -0.38 -5.94 -0.31 7.31e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7843479 0.601 rs4872204 chr8:21841396 T/C cg17168535 chr8:21777572 XPO7 0.83 15.3 0.64 2.11e-40 Mean corpuscular volume; LUSC trans rs12570744 0.745 rs12764177 chr10:6792567 A/C cg11642127 chr8:142593671 NA 0.3 6.08 0.32 3.2e-9 Response to anti-TNF therapy in rheumatoid arthritis; LUSC cis rs1215050 0.791 rs2695472 chr4:98855127 T/C cg05340658 chr4:99064831 C4orf37 -0.44 -6.95 -0.36 1.94e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg27572855 chr1:25598939 RHD 0.46 8.15 0.41 7.53e-15 Erythrocyte sedimentation rate; LUSC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg18350739 chr11:68623251 NA -0.37 -6.61 -0.34 1.48e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs6499188 0.522 rs8046299 chr16:68672346 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.6 7.99 0.4 2.2e-14 Ulcerative colitis; LUSC cis rs2346177 0.874 rs11125075 chr2:46656344 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.48 -7.3 -0.37 2.18e-12 HDL cholesterol; LUSC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC trans rs11098499 0.789 rs9991166 chr4:120237851 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.51 7.54 0.38 4.55e-13 Schizophrenia; LUSC cis rs7666738 0.515 rs13118898 chr4:98792893 T/A cg17366294 chr4:99064904 C4orf37 0.55 8.77 0.43 9.47e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg26408565 chr15:76604113 ETFA -0.51 -8.31 -0.41 2.46e-15 Blood metabolite levels; LUSC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg23985595 chr17:80112537 CCDC57 -0.3 -5.75 -0.3 2.05e-8 Life satisfaction; LUSC cis rs6840360 0.571 rs62327274 chr4:152548012 C/T cg22705602 chr4:152727874 NA -0.32 -6.41 -0.33 4.85e-10 Intelligence (multi-trait analysis); LUSC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 7.68 0.39 1.78e-13 Schizophrenia; LUSC cis rs7193541 0.684 rs4887783 chr16:74700743 G/C cg01733217 chr16:74700730 RFWD3 1.0 22.64 0.78 2.04e-69 Multiple myeloma; LUSC trans rs72674100 1.000 rs28539607 chr4:97977256 T/G cg16405019 chr1:18959625 PAX7 -0.59 -6.39 -0.33 5.5e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg21880101 chr17:80066754 CCDC57 -0.31 -5.8 -0.3 1.54e-8 Life satisfaction; LUSC cis rs300703 0.678 rs423643 chr2:199648 A/C cg21211680 chr2:198530 NA 0.69 7.79 0.39 8.61e-14 Blood protein levels; LUSC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs10802346 0.524 rs10802356 chr1:246385857 T/C cg22732515 chr19:44031385 ETHE1 0.63 10.52 0.5 1.55e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7568458 0.837 rs35565292 chr2:85790316 T/A cg02493740 chr2:85810744 VAMP5 -0.35 -6.07 -0.32 3.49e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7851660 0.805 rs4255258 chr9:100647545 A/G cg13688889 chr9:100608707 NA -0.56 -8.49 -0.42 6.93e-16 Strep throat; LUSC cis rs7819412 1.000 rs7819412 chr8:11045161 A/G cg21775007 chr8:11205619 TDH 0.57 8.26 0.41 3.4e-15 Triglycerides; LUSC cis rs7681440 0.874 rs1372525 chr4:90776165 G/A cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.31 1.15e-8 Dementia with Lewy bodies; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg11235426 chr6:292522 DUSP22 0.68 11.09 0.52 1.46e-24 Menopause (age at onset); LUSC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg07701084 chr6:150067640 NUP43 0.56 8.65 0.43 2.28e-16 Lung cancer; LUSC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg11494091 chr17:61959527 GH2 0.4 6.91 0.35 2.47e-11 Height; LUSC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg01368799 chr11:117014884 PAFAH1B2 0.52 6.82 0.35 4.31e-11 Blood protein levels; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13732083 chr21:47605072 C21orf56 -0.39 -5.84 -0.3 1.25e-8 Testicular germ cell tumor; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07725970 chr12:27091851 FGFR1OP2;C12orf11 0.38 6.0 0.31 5.19e-9 Triglycerides; LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg03934478 chr11:495069 RNH1 0.85 10.05 0.48 6.2e-21 Body mass index; LUSC cis rs9788682 0.747 rs2915695 chr15:78739471 T/C cg18825076 chr15:78729989 IREB2 -0.47 -6.45 -0.33 3.93e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg11916186 chr1:36689760 THRAP3 0.45 6.26 0.32 1.17e-9 Mosquito bite size; LUSC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.86 0.35 3.42e-11 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.91 0.4 3.91e-14 Crohn's disease; LUSC cis rs1982963 0.585 rs77091361 chr14:52486961 C/T cg10843707 chr14:52510701 NID2 0.45 6.2 0.32 1.67e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11105298 0.891 rs1008764 chr12:89887649 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.04e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.64 6.3 0.33 9.42e-10 Cerebrospinal P-tau181p levels; LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.2 -0.37 4.1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg17178900 chr1:205818956 PM20D1 0.79 13.57 0.6 1.08e-33 Menarche (age at onset); LUSC cis rs3020736 0.500 rs6002605 chr22:42494335 A/G cg04733989 chr22:42467013 NAGA -0.62 -9.72 -0.47 7.81e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs77741769 0.529 rs3901854 chr12:121225526 C/T cg02419362 chr12:121203948 SPPL3 0.46 8.43 0.42 1.03e-15 Mean corpuscular volume; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg00684032 chr4:1343700 KIAA1530 0.33 6.02 0.31 4.69e-9 Longevity; LUSC cis rs6545883 0.895 rs2442029 chr2:61679552 G/T cg15711740 chr2:61764176 XPO1 -0.46 -6.91 -0.35 2.39e-11 Tuberculosis; LUSC cis rs72781680 0.665 rs72788298 chr2:24104293 T/C cg08917208 chr2:24149416 ATAD2B 0.61 7.08 0.36 8.37e-12 Lymphocyte counts; LUSC cis rs4727027 0.870 rs11524138 chr7:148799125 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.47 0.33 3.55e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11098499 0.908 rs9995234 chr4:120321827 A/G cg24375607 chr4:120327624 NA 0.79 11.23 0.52 4.98e-25 Corneal astigmatism; LUSC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg03433033 chr1:76189801 ACADM 0.84 15.03 0.64 2.3e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9560113 1.000 rs9555806 chr13:112179954 G/A cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.54e-13 Menarche (age at onset); LUSC cis rs9326248 0.581 rs10892053 chr11:116857003 C/T cg01368799 chr11:117014884 PAFAH1B2 0.61 9.41 0.46 8.52e-19 Blood protein levels; LUSC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7408868 1.000 rs2074622 chr19:15277620 G/C cg14696996 chr19:15285081 NOTCH3 0.96 9.25 0.45 2.69e-18 Pulse pressure; LUSC cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg25019033 chr10:957182 NA -0.53 -6.06 -0.31 3.74e-9 Eosinophil percentage of granulocytes; LUSC cis rs7075426 0.669 rs3758520 chr10:88233628 C/G cg07322936 chr10:88137208 NA 0.46 6.57 0.34 1.9e-10 Migraine without aura; LUSC cis rs62400317 0.826 rs11968637 chr6:45348633 G/A cg18551225 chr6:44695536 NA -0.44 -7.3 -0.37 2.09e-12 Total body bone mineral density; LUSC cis rs3008870 0.583 rs2815369 chr1:67500894 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 13.82 0.6 1.13e-34 Lymphocyte percentage of white cells; LUSC cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg11608241 chr8:8085544 FLJ10661 -0.36 -5.67 -0.3 3.08e-8 Mood instability; LUSC cis rs12541635 0.677 rs1429681 chr8:107048808 A/C cg10147462 chr8:107024639 NA 0.66 13.82 0.6 1.17e-34 Age of smoking initiation; LUSC cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.03 0.55 6.07e-28 Chronic sinus infection; LUSC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg20406979 chr6:167373233 NA -0.26 -6.16 -0.32 2.1e-9 Crohn's disease; LUSC cis rs3741151 0.773 rs17244602 chr11:73219907 A/G cg17517138 chr11:73019481 ARHGEF17 -0.71 -6.37 -0.33 6.41e-10 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg02772935 chr3:125709198 NA -0.48 -6.18 -0.32 1.89e-9 Blood pressure (smoking interaction); LUSC trans rs11699445 0.863 rs6135517 chr20:15770383 A/G cg07106432 chr2:27593462 SNX17;EIF2B4 -0.38 -6.29 -0.33 9.96e-10 TRAIL levels; LUSC trans rs7824557 0.628 rs34237267 chr8:11197301 G/C cg06636001 chr8:8085503 FLJ10661 0.45 6.56 0.34 2.01e-10 Retinal vascular caliber; LUSC trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg25282410 chr6:160211355 TCP1;MRPL18 1.04 15.68 0.65 6.49e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg22907277 chr7:1156413 C7orf50 0.55 8.1 0.41 1.02e-14 Longevity;Endometriosis; LUSC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg02807482 chr3:125708958 NA -0.51 -6.36 -0.33 6.82e-10 Blood pressure (smoking interaction); LUSC cis rs4820539 1.000 rs4822357 chr22:23473231 A/G cg21100191 chr22:23484243 RTDR1 0.82 13.97 0.61 3.08e-35 Bone mineral density; LUSC cis rs7215564 0.818 rs35638109 chr17:78657367 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.04 0.31 4.18e-9 Myopia (pathological); LUSC cis rs500891 0.525 rs1144181 chr6:84023171 G/A cg08257003 chr6:84140564 ME1 0.33 7.85 0.39 5.81e-14 Platelet-derived growth factor BB levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19400780 chr1:10490496 APITD1 -0.45 -6.8 -0.35 4.86e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11122272 0.735 rs2355873 chr1:231477442 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.6 -8.96 -0.44 2.38e-17 Hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01169772 chr5:41904236 C5orf51 0.47 6.46 0.33 3.73e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6459788 0.605 rs887628 chr7:157237589 G/A cg03453431 chr7:157225567 NA -0.59 -10.72 -0.51 3.12e-23 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs360798 0.512 rs34104251 chr2:62995183 A/G cg17519650 chr2:63277830 OTX1 -0.46 -6.36 -0.33 6.62e-10 Coronary artery disease; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg07212818 chr11:638076 DRD4 -0.38 -6.49 -0.33 3.07e-10 Systemic lupus erythematosus; LUSC cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.4 0.33 5.36e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4363385 0.574 rs6683514 chr1:152984397 A/G cg00922841 chr1:152955080 SPRR1A -0.39 -6.55 -0.34 2.18e-10 Inflammatory skin disease; LUSC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.8 0.47 4.42e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg22029157 chr1:209979665 IRF6 0.8 10.25 0.49 1.27e-21 Cleft lip with or without cleft palate; LUSC cis rs2760061 0.626 rs591582 chr1:228117360 C/A cg02753203 chr1:228287806 NA -0.66 -11.45 -0.53 7.96e-26 Diastolic blood pressure; LUSC cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.91e-16 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20069020 chr7:108166782 PNPLA8 0.43 6.03 0.31 4.26e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg16482183 chr6:26056742 HIST1H1C 1.07 14.99 0.63 3.33e-39 Iron status biomarkers; LUSC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg19680485 chr15:31195859 MTMR15 0.45 6.01 0.31 4.76e-9 Huntington's disease progression; LUSC cis rs55665837 1.000 rs12792120 chr11:14469443 G/T cg19336497 chr11:14380999 RRAS2 -0.37 -7.49 -0.38 6.29e-13 Vitamin D levels; LUSC cis rs4319547 0.695 rs1803290 chr12:122865029 T/C cg05707623 chr12:122985044 ZCCHC8 0.66 8.11 0.41 9.63e-15 Body mass index; LUSC cis rs4243830 0.850 rs12744992 chr1:6601290 G/A cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.03 -0.31 4.3e-9 Body mass index; LUSC cis rs500891 0.730 rs1145917 chr6:83988861 T/C cg08257003 chr6:84140564 ME1 0.33 7.15 0.36 5.67e-12 Platelet-derived growth factor BB levels; LUSC cis rs11785400 0.793 rs4736364 chr8:143742113 C/T cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg03676636 chr4:99064102 C4orf37 0.27 5.84 0.3 1.26e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg17892150 chr10:133769511 PPP2R2D -0.65 -9.02 -0.44 1.55e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9325144 0.650 rs6582631 chr12:38744135 T/C cg26384229 chr12:38710491 ALG10B 0.6 9.52 0.46 3.63e-19 Morning vs. evening chronotype; LUSC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg18827107 chr12:86230957 RASSF9 -0.46 -6.97 -0.36 1.74e-11 Major depressive disorder; LUSC trans rs4911259 0.552 rs13037833 chr20:31459562 C/T cg09781936 chr22:19749961 TBX1 -0.34 -6.02 -0.31 4.72e-9 Inflammatory bowel disease; LUSC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.82 -0.35 4.17e-11 Tonsillectomy; LUSC cis rs6121246 0.529 rs112367115 chr20:30178627 G/A cg13852791 chr20:30311386 BCL2L1 0.69 7.15 0.36 5.35e-12 Mean corpuscular hemoglobin; LUSC cis rs7084921 0.578 rs12783521 chr10:101871748 C/A cg11888571 chr10:102027403 CWF19L1 -0.45 -6.07 -0.32 3.44e-9 Bone mineral density; LUSC cis rs34779708 0.931 rs2384287 chr10:35340559 A/G cg04310649 chr10:35416472 CREM -0.39 -6.05 -0.31 3.92e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7605378 1.000 rs797163 chr2:200696387 G/A cg23649088 chr2:200775458 C2orf69 0.53 8.21 0.41 4.91e-15 Osteoporosis; LUSC cis rs11098499 0.754 rs11732087 chr4:120239831 A/G cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC cis rs763121 0.925 rs9835 chr22:39130971 A/G cg06022373 chr22:39101656 GTPBP1 0.74 12.04 0.55 5.83e-28 Menopause (age at onset); LUSC cis rs2046867 0.818 rs67355490 chr3:72830935 T/C cg25664220 chr3:72788482 NA -0.71 -11.93 -0.55 1.48e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg04362960 chr10:104952993 NT5C2 0.56 8.07 0.4 1.31e-14 Arsenic metabolism; LUSC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg17554472 chr22:41940697 POLR3H -0.48 -6.03 -0.31 4.42e-9 Vitiligo; LUSC cis rs4953404 0.613 rs10180473 chr2:46904168 A/G cg09399716 chr2:46890238 NA -0.29 -6.5 -0.34 2.86e-10 Pulse pressure (alcohol consumption interaction); LUSC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.53 0.38 4.69e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.37 0.56 3.34e-29 Prudent dietary pattern; LUSC cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg24642439 chr20:33292090 TP53INP2 0.47 7.17 0.37 4.81e-12 Glomerular filtration rate (creatinine); LUSC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg08859206 chr1:53392774 SCP2 -0.42 -6.72 -0.35 7.68e-11 Monocyte count; LUSC cis rs5758511 0.680 rs1033460 chr22:42619308 A/G cg00645731 chr22:42541494 CYP2D7P1 0.57 10.0 0.48 8.88e-21 Birth weight; LUSC cis rs34891900 0.507 rs2008085 chr22:18204316 T/G cg08824373 chr22:18117835 NA -0.41 -6.2 -0.32 1.66e-9 Sum neutrophil eosinophil counts; LUSC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg26335602 chr6:28129616 ZNF389 0.46 6.29 0.33 9.88e-10 Depression; LUSC cis rs1595825 0.945 rs76877032 chr2:198840000 G/A cg00982548 chr2:198649783 BOLL -0.57 -7.13 -0.36 6.43e-12 Ulcerative colitis; LUSC cis rs7937682 0.575 rs7124696 chr11:111747297 A/G cg09085632 chr11:111637200 PPP2R1B 0.96 13.34 0.59 8.01e-33 Primary sclerosing cholangitis; LUSC cis rs11711311 1.000 rs9828099 chr3:113518402 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.82 -0.3 1.41e-8 IgG glycosylation; LUSC cis rs1044826 0.692 rs295484 chr3:139231782 A/G cg15131784 chr3:139108705 COPB2 -0.39 -6.35 -0.33 6.9e-10 Obesity-related traits; LUSC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg06028605 chr16:24865363 SLC5A11 -0.68 -10.39 -0.49 4.11e-22 Intelligence (multi-trait analysis); LUSC cis rs9296092 0.517 rs7743064 chr6:33470529 C/T cg13560919 chr6:33536144 NA -0.78 -13.33 -0.59 8.65e-33 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs1008375 1.000 rs3815414 chr4:17606659 A/G cg18681998 chr4:17616180 MED28 -0.84 -15.46 -0.65 4.84e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg02389323 chr16:88786976 FAM38A -1.03 -10.98 -0.51 3.77e-24 Plateletcrit; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10840526 chr7:100813242 NA 0.41 6.11 0.32 2.77e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.563 rs2425090 chr20:34304783 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.56 -0.42 4.24e-16 Total cholesterol levels; LUSC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg26061582 chr7:22766209 IL6 0.49 7.02 0.36 1.25e-11 Lung cancer; LUSC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg07741184 chr6:167504864 NA 0.36 6.52 0.34 2.55e-10 Crohn's disease; LUSC trans rs2898290 0.540 rs35005793 chr8:11450472 G/A cg15556689 chr8:8085844 FLJ10661 0.59 8.85 0.44 5.14e-17 Systolic blood pressure; LUSC cis rs912057 0.609 rs1294431 chr6:6745003 G/C cg06612196 chr6:6737390 NA 0.57 11.14 0.52 1.05e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg03929089 chr4:120376271 NA 0.82 11.44 0.53 8.71e-26 Coronary artery disease; LUSC cis rs7568458 0.709 rs11895399 chr2:85753806 C/A cg23752985 chr2:85803571 VAMP8 0.31 6.06 0.31 3.7e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7599312 0.532 rs16848751 chr2:213389346 A/G cg16329650 chr2:213403929 ERBB4 0.48 7.14 0.36 5.95e-12 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs950027 0.620 rs1153862 chr15:45631868 A/G cg14582100 chr15:45693742 SPATA5L1 0.45 8.54 0.42 4.94e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs11168618 0.715 rs35367885 chr12:48919660 G/A cg24011408 chr12:48396354 COL2A1 0.4 6.39 0.33 5.6e-10 Adiponectin levels; LUSC cis rs6060717 0.536 rs6060676 chr20:34498551 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.66 -0.3 3.32e-8 Hip circumference adjusted for BMI; LUSC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg10792982 chr14:105748885 BRF1 0.48 8.6 0.43 3.2e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg00343986 chr7:65444356 GUSB -0.43 -6.45 -0.33 3.86e-10 Aortic root size; LUSC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.29 0.33 9.74e-10 Mean platelet volume; LUSC cis rs13315871 0.929 rs1554124 chr3:58268968 C/G cg20936604 chr3:58311152 NA -0.74 -7.39 -0.37 1.19e-12 Cholesterol, total; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg01334818 chr3:38496325 LOC100128640;ACVR2B 0.48 6.08 0.32 3.36e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg06784218 chr1:46089804 CCDC17 -0.47 -9.06 -0.44 1.09e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs3733585 0.673 rs7376948 chr4:9954708 G/A cg26043149 chr18:55253948 FECH -0.45 -6.99 -0.36 1.5e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg07677032 chr17:61819896 STRADA -0.49 -8.23 -0.41 4.39e-15 Prudent dietary pattern; LUSC cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs59698941 0.882 rs68171951 chr5:132290711 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.46 6.4 0.33 5.21e-10 Total body bone mineral density; LUSC cis rs7666738 0.606 rs3846447 chr4:99099907 G/A cg17366294 chr4:99064904 C4orf37 0.54 9.22 0.45 3.48e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs11190604 1.000 rs74210981 chr10:102287520 C/T cg16342193 chr10:102329863 NA -0.39 -6.76 -0.35 6.11e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg07936489 chr17:37558343 FBXL20 0.72 10.31 0.49 8.05e-22 Glomerular filtration rate (creatinine); LUSC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg03060546 chr3:49711283 APEH 0.7 11.63 0.54 1.78e-26 Resting heart rate; LUSC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg25124228 chr12:125621409 AACS 0.41 6.03 0.31 4.25e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1670533 1.000 rs62294756 chr4:1097676 G/A cg27284194 chr4:1044797 NA -0.57 -8.37 -0.42 1.56e-15 Recombination rate (females); LUSC trans rs35110281 0.626 rs162388 chr21:44936032 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.94 0.44 2.64e-17 Mean corpuscular volume; LUSC cis rs3741151 1.000 rs111882289 chr11:73053714 T/C cg17517138 chr11:73019481 ARHGEF17 1.04 8.68 0.43 1.78e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7592578 0.882 rs2192010 chr2:191462133 C/T cg11845111 chr2:191398756 TMEM194B -0.86 -11.4 -0.53 1.21e-25 Diastolic blood pressure; LUSC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg20135002 chr11:47629003 NA -0.51 -7.88 -0.4 4.72e-14 Subjective well-being; LUSC cis rs9650657 0.571 rs11783247 chr8:10788875 C/T cg27411982 chr8:10470053 RP1L1 -0.5 -7.95 -0.4 2.91e-14 Neuroticism; LUSC cis rs6906287 0.669 rs12208253 chr6:118925097 G/C cg21191810 chr6:118973309 C6orf204 0.31 5.77 0.3 1.83e-8 Electrocardiographic conduction measures; LUSC cis rs11971779 0.680 rs6963867 chr7:139059964 T/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs11190604 1.000 rs11190597 chr10:102293676 A/T cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg23649088 chr2:200775458 C2orf69 -0.58 -7.05 -0.36 1.05e-11 Schizophrenia; LUSC cis rs11677416 1.000 rs11677416 chr2:113529240 A/G cg27083787 chr2:113543245 IL1A 0.48 7.58 0.38 3.49e-13 Response to antipsychotic treatment in schizophrenia (working memory); LUSC trans rs853679 0.607 rs66886492 chr6:28089731 C/T cg06606381 chr12:133084897 FBRSL1 -1.04 -8.89 -0.44 3.79e-17 Depression; LUSC trans rs3960554 0.867 rs10239209 chr7:75804085 G/A cg19862616 chr7:65841803 NCRNA00174 0.9 10.63 0.5 6.43e-23 Eotaxin levels; LUSC cis rs4363385 0.818 rs4845514 chr1:153000820 T/C cg25856811 chr1:152973957 SPRR3 -0.36 -6.0 -0.31 5.07e-9 Inflammatory skin disease; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.52 0.76 4.62e-65 Prudent dietary pattern; LUSC cis rs2798269 0.510 rs7985023 chr13:22123600 A/G cg18095732 chr13:22033692 ZDHHC20 0.4 6.23 0.32 1.39e-9 PR segment; LUSC cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg24812749 chr6:127587940 RNF146 0.71 10.21 0.49 1.78e-21 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21218899 chr19:46010592 VASP -0.42 -6.22 -0.32 1.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6500395 1.000 rs2111243 chr16:48724897 C/T cg04672837 chr16:48644449 N4BP1 -0.48 -7.11 -0.36 7.05e-12 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs4718428 0.672 rs12530806 chr7:66390724 A/G cg18876405 chr7:65276391 NA 0.49 6.65 0.34 1.22e-10 Corneal structure; LUSC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg24531977 chr5:56204891 C5orf35 -0.73 -10.51 -0.5 1.58e-22 Coronary artery disease; LUSC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg16049864 chr8:95962084 TP53INP1 -0.43 -7.13 -0.36 6.38e-12 Type 2 diabetes; LUSC cis rs7674212 1.000 rs7691873 chr4:103987899 C/T cg16532752 chr4:104119610 CENPE 0.41 6.21 0.32 1.53e-9 Type 2 diabetes; LUSC cis rs62408225 1.000 rs55771973 chr6:90981319 T/G cg06866423 chr6:90926672 BACH2 0.42 5.96 0.31 6.26e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7520050 1.000 rs12143096 chr1:46469763 G/A cg06784218 chr1:46089804 CCDC17 -0.29 -5.69 -0.3 2.78e-8 Red blood cell count;Reticulocyte count; LUSC cis rs714027 0.605 rs193476 chr22:30450521 G/A cg11564601 chr22:30592435 NA -0.32 -5.65 -0.3 3.52e-8 Lymphocyte counts; LUSC cis rs9457247 1.000 rs408040 chr6:167398903 A/T cg25258033 chr6:167368657 RNASET2 0.47 7.84 0.39 6.15e-14 Crohn's disease; LUSC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg18876405 chr7:65276391 NA -0.55 -8.77 -0.43 9.25e-17 Aortic root size; LUSC cis rs4363385 0.510 rs12083211 chr1:153032131 A/T cg25856811 chr1:152973957 SPRR3 0.37 6.13 0.32 2.46e-9 Inflammatory skin disease; LUSC trans rs61931739 0.500 rs9669027 chr12:34583528 C/T cg13010199 chr12:38710504 ALG10B -0.56 -8.82 -0.43 6.69e-17 Morning vs. evening chronotype; LUSC cis rs8141797 0.901 rs8140812 chr22:24553535 C/T cg00411358 chr22:24577142 SUSD2 -0.51 -5.82 -0.3 1.37e-8 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs7923609 0.967 rs7896783 chr10:65162153 G/A cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 3.84e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs11098499 0.954 rs10017543 chr4:120321420 G/A cg25214090 chr10:38739885 LOC399744 0.54 7.91 0.4 3.89e-14 Corneal astigmatism; LUSC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg22442454 chr1:209979470 IRF6 0.43 5.88 0.31 9.86e-9 Cleft lip with or without cleft palate; LUSC cis rs3772130 1.000 rs3772128 chr3:121345094 G/T cg01951420 chr3:121553821 IQCB1;EAF2 0.66 9.49 0.46 4.61e-19 Cognitive performance; LUSC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg22834771 chr12:69754056 YEATS4 -0.52 -7.86 -0.4 5.24e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg07677032 chr17:61819896 STRADA 0.53 8.77 0.43 9.58e-17 Prudent dietary pattern; LUSC cis rs9369695 0.883 rs9381581 chr6:47580695 G/A cg20196966 chr6:47445060 CD2AP 0.43 6.08 0.32 3.24e-9 Reticulocyte count; LUSC cis rs9311676 0.632 rs56033718 chr3:58446398 A/G cg13750441 chr3:58318267 PXK 0.35 6.83 0.35 4.08e-11 Systemic lupus erythematosus; LUSC cis rs2046867 0.818 rs6808341 chr3:72914847 A/G cg25664220 chr3:72788482 NA -0.58 -10.82 -0.51 1.34e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg06212747 chr3:49208901 KLHDC8B 0.46 6.37 0.33 6.36e-10 Parkinson's disease; LUSC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs16912285 0.688 rs7929701 chr11:24357964 A/C ch.11.24196551F chr11:24239977 NA 0.85 8.17 0.41 6.47e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg25427524 chr10:38739819 LOC399744 -0.67 -12.11 -0.55 3.2e-28 Extrinsic epigenetic age acceleration; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg07167872 chr1:205819463 PM20D1 0.88 17.16 0.68 9.06e-48 Menarche (age at onset); LUSC cis rs3126085 0.935 rs1353436 chr1:152172658 G/A cg03465714 chr1:152285911 FLG -0.4 -5.75 -0.3 2.05e-8 Atopic dermatitis; LUSC cis rs7202877 0.706 rs247450 chr16:75490017 C/A cg03315344 chr16:75512273 CHST6 -0.47 -6.39 -0.33 5.59e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs35146811 0.844 rs12705070 chr7:99656927 A/G cg22906224 chr7:99728672 NA 0.52 7.57 0.38 3.59e-13 Coronary artery disease; LUSC trans rs561341 0.710 rs9900031 chr17:30199537 T/C cg20587970 chr11:113659929 NA 1.04 11.06 0.52 1.91e-24 Hip circumference adjusted for BMI; LUSC cis rs3820928 0.904 rs2195487 chr2:227759720 G/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.73 -0.39 1.3e-13 Pulmonary function; LUSC cis rs12600856 1 rs12600856 chr17:38163295 T/C cg17467752 chr17:38218738 THRA 0.77 12.45 0.56 1.7e-29 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg12573674 chr2:1569213 NA -0.55 -6.14 -0.32 2.36e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs727505 1.000 rs56313563 chr7:124507003 G/A cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.23 0.32 1.38e-9 Electroencephalogram traits; LUSC cis rs7481584 0.646 rs434114 chr11:3050210 A/G cg08508325 chr11:3079039 CARS 0.38 8.45 0.42 9.13e-16 Calcium levels; LUSC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.27 0.49 1.13e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6582630 0.679 rs10785514 chr12:38573689 T/C cg13010199 chr12:38710504 ALG10B 0.47 7.14 0.36 6e-12 Drug-induced liver injury (flucloxacillin); LUSC cis rs1784581 0.674 rs1789996 chr6:162391895 T/C cg17173639 chr6:162384350 PARK2 -0.68 -12.21 -0.56 1.3e-28 Itch intensity from mosquito bite; LUSC cis rs9633740 0.545 rs2343306 chr10:82230146 A/G cg00277334 chr10:82204260 NA 0.67 7.98 0.4 2.42e-14 Post bronchodilator FEV1; LUSC cis rs7945718 0.870 rs10831903 chr11:12758660 C/T cg25843174 chr11:12811716 TEAD1 0.32 6.96 0.36 1.78e-11 Educational attainment (years of education); LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg18404041 chr3:52824283 ITIH1 -0.59 -11.4 -0.53 1.17e-25 Bipolar disorder; LUSC trans rs6502050 0.799 rs6502089 chr17:80169523 G/A cg07393940 chr7:158741817 NA 0.36 6.46 0.33 3.77e-10 Life satisfaction; LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg07703079 chr11:430292 ANO9 0.61 6.35 0.33 7.1e-10 Body mass index; LUSC cis rs3858526 0.834 rs10838989 chr11:5978057 A/G cg05234568 chr11:5960015 NA -0.63 -8.89 -0.44 3.96e-17 DNA methylation (variation); LUSC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.09e-12 Mean platelet volume; LUSC cis rs11971779 0.688 rs8137 chr7:139104461 A/C cg23387468 chr7:139079360 LUC7L2 -0.41 -6.3 -0.33 9.29e-10 Diisocyanate-induced asthma; LUSC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg11764359 chr7:65958608 NA 0.7 10.95 0.51 4.71e-24 Aortic root size; LUSC cis rs4499344 0.693 rs8106502 chr19:33097796 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.66 0.57 2.92e-30 Mean platelet volume; LUSC cis rs2242663 0.798 rs1945302 chr11:66337498 C/T cg18002602 chr11:66138449 SLC29A2 -0.35 -6.21 -0.32 1.56e-9 Bipolar disorder; LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs892961 0.806 rs312910 chr17:75413961 A/C cg05865280 chr17:75406074 SEPT9 0.48 10.29 0.49 9.32e-22 Airflow obstruction; LUSC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg17376030 chr22:41985996 PMM1 -0.47 -5.84 -0.3 1.25e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg13939156 chr17:80058883 NA 0.34 6.56 0.34 2.06e-10 Life satisfaction; LUSC cis rs9831754 0.906 rs1588650 chr3:78410750 T/G cg06138941 chr3:78371609 NA -0.65 -9.37 -0.46 1.09e-18 Calcium levels; LUSC cis rs9790314 0.875 rs336580 chr3:161082982 A/T cg03342759 chr3:160939853 NMD3 -0.49 -8.17 -0.41 6.3e-15 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg25767906 chr1:53392781 SCP2 -0.41 -7.03 -0.36 1.21e-11 Monocyte count; LUSC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg10909506 chr17:38081995 ORMDL3 0.34 6.14 0.32 2.39e-9 Self-reported allergy; LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg08736216 chr1:53307985 ZYG11A 0.3 6.06 0.31 3.77e-9 Monocyte count; LUSC cis rs10761482 0.601 rs1954117 chr10:62210588 A/C cg18175470 chr10:62150864 ANK3 -0.53 -7.37 -0.37 1.32e-12 Schizophrenia; LUSC cis rs9549367 0.713 rs3024745 chr13:113821598 A/G cg18105134 chr13:113819100 PROZ -0.76 -10.53 -0.5 1.4e-22 Platelet distribution width; LUSC cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.64 0.57 3.36e-30 Motion sickness; LUSC cis rs9650657 0.615 rs1549796 chr8:10692359 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -6.01 -0.31 4.74e-9 Neuroticism; LUSC cis rs1348850 0.645 rs11889272 chr2:178432378 C/T cg22681709 chr2:178499509 PDE11A -0.4 -5.7 -0.3 2.57e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg11062466 chr8:58055876 NA 0.66 9.08 0.44 9.89e-18 Developmental language disorder (linguistic errors); LUSC cis rs9341808 0.667 rs2476826 chr6:80876064 C/T cg08355045 chr6:80787529 NA 0.48 8.21 0.41 4.82e-15 Sitting height ratio; LUSC cis rs738322 0.718 rs2899297 chr22:38594668 A/G cg25457927 chr22:38595422 NA -0.51 -11.35 -0.53 1.74e-25 Cutaneous nevi; LUSC cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.4e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg07716408 chr11:68623521 NA -0.3 -5.77 -0.3 1.8e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg05585544 chr11:47624801 NA 0.41 7.24 0.37 3.2e-12 Subjective well-being; LUSC cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg26647111 chr11:31128758 NA -0.43 -6.14 -0.32 2.36e-9 Red blood cell count; LUSC cis rs7246967 0.604 rs12975793 chr19:22862844 A/C cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs12618769 0.652 rs3820941 chr2:99233781 C/T cg10123293 chr2:99228465 UNC50 0.46 7.56 0.38 3.95e-13 Bipolar disorder; LUSC cis rs7772486 0.902 rs1331643 chr6:146398873 T/A cg05347473 chr6:146136440 FBXO30 0.42 6.99 0.36 1.52e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs3768617 0.510 rs4651145 chr1:183098900 T/C ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15941164 chr5:77072171 TBCA 0.43 6.19 0.32 1.78e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg05294307 chr14:35346193 BAZ1A -0.61 -7.4 -0.38 1.15e-12 Psoriasis; LUSC cis rs8078723 1.000 rs4794824 chr17:38179290 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -7.13 -0.36 6.15e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg06022373 chr22:39101656 GTPBP1 0.77 12.61 0.57 4.28e-30 Menopause (age at onset); LUSC cis rs2742417 0.603 rs1019129 chr3:45780780 T/C cg04837898 chr3:45731254 SACM1L -0.45 -7.45 -0.38 8.27e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg23262073 chr20:60523788 NA -0.4 -5.67 -0.3 3.15e-8 Body mass index; LUSC trans rs10982256 0.870 rs998547 chr9:117275012 G/A cg03506640 chr14:85997753 FLRT2 -0.35 -5.95 -0.31 6.65e-9 Bipolar disorder; LUSC cis rs1003719 0.680 rs2154537 chr21:38502012 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.34 -0.49 6.24e-22 Eye color traits; LUSC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.37 -0.42 1.6e-15 Height; LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg14092988 chr3:52407081 DNAH1 0.33 6.32 0.33 8.52e-10 Bipolar disorder; LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg04944784 chr2:26401820 FAM59B -0.75 -11.0 -0.52 3.24e-24 Gut microbiome composition (summer); LUSC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg03806693 chr22:41940476 POLR3H -0.97 -13.87 -0.6 7.3e-35 Vitiligo; LUSC cis rs1568889 1.000 rs2354427 chr11:28049623 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC trans rs747782 0.527 rs2279822 chr11:48146114 C/T cg03929089 chr4:120376271 NA 0.71 6.42 0.33 4.63e-10 Intraocular pressure; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02700454 chr8:126441997 TRIB1 -0.45 -6.55 -0.34 2.16e-10 Electrocardiographic conduction measures; LUSC cis rs7605827 0.897 rs2241238 chr2:15656560 T/C cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs921968 0.565 rs62191658 chr2:219630294 A/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.15 -0.49 2.88e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.98 -0.4 2.35e-14 Crohn's disease; LUSC trans rs3733585 0.673 rs4467563 chr4:9953460 A/T cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.5 -7.75 -0.39 1.12e-13 Prudent dietary pattern; LUSC cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs40363 1.000 rs37769 chr16:3514580 C/G cg22508957 chr16:3507546 NAT15 0.84 10.81 0.51 1.45e-23 Tuberculosis; LUSC trans rs853679 1.000 rs68141011 chr6:28217797 G/T cg06606381 chr12:133084897 FBRSL1 -0.58 -6.68 -0.34 9.77e-11 Depression; LUSC cis rs2354432 0.607 rs11239980 chr1:146782698 G/A cg25205988 chr1:146714368 CHD1L -1.02 -9.56 -0.46 2.63e-19 Mitochondrial DNA levels; LUSC cis rs7264396 0.515 rs2425134 chr20:34339439 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.55 -0.42 4.5e-16 Total cholesterol levels; LUSC cis rs1113500 0.933 rs3909076 chr1:108631760 T/C cg11967332 chr1:108735228 SLC25A24 0.38 5.76 0.3 1.92e-8 Growth-regulated protein alpha levels; LUSC cis rs2540226 0.967 rs12470473 chr2:40005290 A/G cg23576258 chr2:39999331 THUMPD2 -0.34 -5.94 -0.31 7.32e-9 Personality dimensions; LUSC cis rs1949733 0.523 rs16842563 chr4:8545146 C/T cg13073564 chr4:8508604 NA 0.34 6.44 0.33 4.28e-10 Response to antineoplastic agents; LUSC cis rs4930561 0.765 rs10896304 chr11:67981714 T/G cg16338278 chr11:67432957 ALDH3B2 0.39 6.47 0.33 3.49e-10 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs1981331 1.000 rs77587985 chr21:47993897 A/G cg23283320 chr21:48055893 PRMT2 1.12 8.14 0.41 7.72e-15 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs4253772 0.872 rs45576734 chr22:46638365 A/G cg09491104 chr22:46646882 C22orf40 -0.59 -6.48 -0.33 3.23e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs12973672 0.812 rs12984022 chr19:35754011 A/C cg12095397 chr19:35769544 USF2 0.43 6.56 0.34 2.02e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11098499 0.863 rs1383533 chr4:120434576 G/A cg09307838 chr4:120376055 NA 0.74 10.88 0.51 8.49e-24 Corneal astigmatism; LUSC cis rs4704187 0.687 rs2059159 chr5:74451178 G/C cg03227963 chr5:74354835 NA 0.32 6.91 0.35 2.44e-11 Response to amphetamines; LUSC cis rs2239547 0.603 rs6805298 chr3:53096552 A/G cg11645453 chr3:52864694 ITIH4 -0.47 -10.96 -0.51 4.26e-24 Schizophrenia; LUSC cis rs1014246 1.000 rs1014246 chr10:118466042 C/T cg14919929 chr10:118506882 NA 0.38 5.88 0.31 9.98e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7727544 0.506 rs10040809 chr5:131343017 A/C cg14196790 chr5:131705035 SLC22A5 0.41 6.73 0.35 7.33e-11 Blood metabolite levels; LUSC cis rs2067615 0.560 rs10861671 chr12:107220927 T/C cg15890332 chr12:107067104 RFX4 0.33 5.95 0.31 6.68e-9 Heart rate; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg18538332 chr22:24372958 LOC391322 -0.48 -8.55 -0.42 4.33e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg06112835 chr11:68658793 MRPL21 0.51 7.54 0.38 4.53e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs11098499 0.954 rs6857105 chr4:120222298 C/G cg25214090 chr10:38739885 LOC399744 0.52 7.48 0.38 6.57e-13 Corneal astigmatism; LUSC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg16680214 chr1:154839983 KCNN3 -0.52 -9.74 -0.47 6.53e-20 Prostate cancer; LUSC cis rs9660992 0.674 rs72745219 chr1:205262271 G/A cg00857998 chr1:205179979 DSTYK 0.62 9.52 0.46 3.48e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg09165964 chr15:75287851 SCAMP5 -1.16 -19.52 -0.73 3.81e-57 Blood trace element (Zn levels); LUSC trans rs1005277 0.579 rs1780145 chr10:38537070 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.2 -0.45 3.96e-18 Extrinsic epigenetic age acceleration; LUSC trans rs4713118 0.586 rs6905516 chr6:28086478 A/G cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Parkinson's disease; LUSC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg06219351 chr7:158114137 PTPRN2 -0.52 -9.48 -0.46 4.82e-19 Calcium levels; LUSC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg27165867 chr14:105738592 BRF1 -0.57 -8.59 -0.43 3.4e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg18876405 chr7:65276391 NA 0.75 13.57 0.6 1.02e-33 Aortic root size; LUSC cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg21535247 chr6:8435926 SLC35B3 -0.61 -9.43 -0.46 6.87e-19 Motion sickness; LUSC cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.28 -0.45 2.17e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs2832077 0.689 rs2832055 chr21:30132382 C/G cg14791747 chr16:20752902 THUMPD1 -0.75 -10.82 -0.51 1.35e-23 Cognitive test performance; LUSC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.63 0.57 3.75e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg23275502 chr19:41860019 TGFB1 0.44 6.71 0.34 8.32e-11 Risky sexual behaviors in alcohol dependence; LUSC cis rs1506636 0.646 rs805789 chr7:123221920 G/T cg03229431 chr7:123269106 ASB15 -0.61 -9.3 -0.45 1.88e-18 Plateletcrit;Platelet count; LUSC cis rs834603 0.575 rs834595 chr7:47472276 C/T cg09696706 chr7:47479511 TNS3 0.33 6.0 0.31 5.04e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg16584290 chr5:462447 EXOC3 -0.34 -5.81 -0.3 1.46e-8 Cystic fibrosis severity; LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg18402987 chr7:1209562 NA 0.73 7.92 0.4 3.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7833986 1.000 rs35883156 chr8:57078933 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.61 8.85 0.44 5.28e-17 Height; LUSC cis rs9660992 0.710 rs1172138 chr1:205246019 G/A cg00857998 chr1:205179979 DSTYK 0.6 9.01 0.44 1.66e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs17818399 0.712 rs13008088 chr2:46781580 C/G cg21681030 chr2:46777652 RHOQ 0.5 7.66 0.39 2.09e-13 Height; LUSC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg00750074 chr16:89608354 SPG7 -0.57 -10.17 -0.49 2.36e-21 Multiple myeloma (IgH translocation); LUSC trans rs1997103 0.954 rs10246216 chr7:55390479 C/T cg20935933 chr6:143382018 AIG1 0.5 7.18 0.37 4.55e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7100689 0.622 rs1890890 chr10:82090643 A/T cg01528321 chr10:82214614 TSPAN14 0.82 12.43 0.56 1.97e-29 Post bronchodilator FEV1; LUSC cis rs951366 0.538 rs3761919 chr1:205694720 G/A cg24503407 chr1:205819492 PM20D1 -0.47 -6.32 -0.33 8.61e-10 Menarche (age at onset); LUSC cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs16912285 0.584 rs7131124 chr11:24249455 A/G ch.11.24196551F chr11:24239977 NA 0.98 11.41 0.53 1.13e-25 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4474465 0.850 rs6592789 chr11:78246767 G/C cg27205649 chr11:78285834 NARS2 0.49 5.87 0.31 1.05e-8 Alzheimer's disease (survival time); LUSC cis rs8114671 0.967 rs6142323 chr20:33788983 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -5.92 -0.31 7.81e-9 Height; LUSC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg06287003 chr12:125626642 AACS -0.38 -6.72 -0.34 8.02e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4363385 0.714 rs4845329 chr1:152974454 G/C cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC cis rs4730250 0.802 rs77936580 chr7:106946343 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.55 -0.46 2.81e-19 Osteoarthritis; LUSC cis rs9388451 0.874 rs1159974 chr6:126090277 C/T cg10911889 chr6:126070802 HEY2 -0.43 -6.72 -0.35 7.75e-11 Brugada syndrome; LUSC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg15839431 chr19:19639596 YJEFN3 -0.61 -6.99 -0.36 1.54e-11 Bipolar disorder; LUSC cis rs57590327 0.508 rs10511101 chr3:81950302 A/C cg07356753 chr3:81810745 GBE1 -0.59 -8.68 -0.43 1.79e-16 Extraversion; LUSC trans rs6502050 0.777 rs11077969 chr17:80085633 A/G cg07393940 chr7:158741817 NA -0.37 -6.64 -0.34 1.27e-10 Life satisfaction; LUSC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg15468180 chr1:107600409 PRMT6 0.38 6.02 0.31 4.53e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs735539 0.914 rs7997065 chr13:21273796 A/G cg04906043 chr13:21280425 IL17D 0.46 8.89 0.44 3.81e-17 Dental caries; LUSC cis rs7615952 0.688 rs17334074 chr3:125540460 A/G cg05084668 chr3:125655381 ALG1L 0.6 8.73 0.43 1.25e-16 Blood pressure (smoking interaction); LUSC trans rs2288327 0.643 rs16866334 chr2:179336672 A/G cg18634211 chr1:26737262 LIN28 0.54 7.05 0.36 1.02e-11 Atrial fibrillation; LUSC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg22857025 chr5:266934 NA -1.15 -16.9 -0.68 9.53e-47 Breast cancer; LUSC cis rs713587 1.000 rs713587 chr2:25158281 C/T cg04586622 chr2:25135609 ADCY3 0.34 6.87 0.35 3.25e-11 Body mass index in non-asthmatics; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02884346 chr4:6271501 WFS1 -0.47 -6.27 -0.32 1.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs9910055 1.000 rs9910055 chr17:42283037 C/T cg13607699 chr17:42295918 UBTF 0.69 10.86 0.51 9.88e-24 Total body bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23200371 chr12:56367680 RAB5B 0.68 6.14 0.32 2.38e-9 Cognitive performance; LUSC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg20936695 chr7:66093774 KCTD7 -0.63 -5.77 -0.3 1.81e-8 Diabetic kidney disease; LUSC cis rs16854884 0.789 rs34096668 chr3:143794483 C/T cg06585982 chr3:143692056 C3orf58 0.46 6.82 0.35 4.34e-11 Economic and political preferences (feminism/equality); LUSC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg17366294 chr4:99064904 C4orf37 0.58 10.3 0.49 8.8e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs950027 0.595 rs2486288 chr15:45712339 T/C cg04036182 chr15:45458818 NA 0.35 5.83 0.3 1.32e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs738322 0.967 rs4385 chr22:38573229 T/C cg17652424 chr22:38574118 PLA2G6 -0.3 -6.58 -0.34 1.84e-10 Cutaneous nevi; LUSC trans rs2665103 0.632 rs3902959 chr15:82544927 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.37 -0.33 6.16e-10 Intelligence (multi-trait analysis); LUSC cis rs975210 0.652 rs4777230 chr15:70365762 A/G cg12349571 chr15:70364359 TLE3 -0.59 -6.8 -0.35 4.93e-11 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; LUSC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg23583168 chr7:148888333 NA -0.85 -14.76 -0.63 2.71e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8072100 0.935 rs78551919 chr17:45626002 A/C cg08085267 chr17:45401833 C17orf57 0.59 9.79 0.47 4.46e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs16976116 0.901 rs28449712 chr15:55500681 A/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC cis rs796364 0.806 rs11689664 chr2:201099961 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.75 -0.39 1.08e-13 Schizophrenia; LUSC cis rs2227930 0.528 rs7643377 chr3:142114694 C/T cg16271453 chr3:142027066 XRN1 -0.53 -9.46 -0.46 5.84e-19 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs9768139 0.935 rs62480865 chr7:158122307 A/C cg24154853 chr7:158122151 PTPRN2 -0.41 -7.76 -0.39 1.03e-13 Calcium levels; LUSC cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg12011299 chr4:100065546 ADH4 0.72 10.78 0.51 1.86e-23 Smoking initiation; LUSC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg23711669 chr6:146136114 FBXO30 0.91 17.52 0.69 3.48e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.96 0.44 2.26e-17 Prudent dietary pattern; LUSC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg03732007 chr1:2071316 PRKCZ -0.59 -10.95 -0.51 4.62e-24 Height; LUSC cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg17366294 chr4:99064904 C4orf37 0.6 10.76 0.51 2.22e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs7739264 1.000 rs9358270 chr6:19780584 C/G cg13431028 chr2:169073609 STK39 0.35 6.02 0.31 4.61e-9 Endometriosis; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.54 6.69 0.34 9.67e-11 Renal function-related traits (BUN); LUSC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg05535760 chr7:792225 HEATR2 -0.74 -7.46 -0.38 7.6e-13 Cerebrospinal P-tau181p levels; LUSC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg13206674 chr6:150067644 NUP43 0.6 9.48 0.46 4.74e-19 Lung cancer; LUSC cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.93 -0.51 5.8e-24 Alzheimer's disease (late onset); LUSC cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.07 -0.44 1.06e-17 Monocyte percentage of white cells; LUSC cis rs6845621 0.901 rs7684524 chr4:18920402 C/A cg12196642 chr4:18937545 NA -0.36 -6.75 -0.35 6.71e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2295359 0.892 rs12029362 chr1:67624231 G/A cg12940439 chr1:67600707 NA 0.37 6.03 0.31 4.38e-9 Psoriasis; LUSC cis rs61990749 0.597 rs2267768 chr14:78216014 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.57 0.34 1.94e-10 Fibroblast growth factor basic levels; LUSC cis rs8044995 0.568 rs55675218 chr16:68323647 G/C cg09835421 chr16:68378352 PRMT7 -0.73 -7.42 -0.38 9.62e-13 Schizophrenia; LUSC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg27572855 chr1:25598939 RHD 0.46 8.37 0.42 1.57e-15 Plateletcrit;Mean corpuscular volume; LUSC cis rs231513 0.911 rs231517 chr17:41961789 C/T cg26893861 chr17:41843967 DUSP3 -0.52 -6.28 -0.33 1.03e-9 Cognitive function; LUSC cis rs896854 0.573 rs11996455 chr8:95853708 G/A cg13393036 chr8:95962371 TP53INP1 -0.42 -8.88 -0.44 4.32e-17 Type 2 diabetes; LUSC trans rs561341 1.000 rs15654 chr17:30326360 A/C cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg11941060 chr3:133502564 NA -0.47 -7.42 -0.38 9.53e-13 Iron status biomarkers; LUSC cis rs478304 0.593 rs4645933 chr11:65485120 C/T cg10518572 chr11:65560635 OVOL1 -0.27 -5.9 -0.31 9.14e-9 Acne (severe); LUSC cis rs7089973 0.624 rs10885613 chr10:116589400 G/A cg03647239 chr10:116582469 FAM160B1 0.45 7.27 0.37 2.55e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.59 -8.76 -0.43 9.75e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs77633900 0.772 rs157769 chr15:76834397 G/A cg21673338 chr15:77095150 SCAPER -0.68 -5.76 -0.3 1.93e-8 Non-glioblastoma glioma;Glioma; LUSC cis rs12530845 1.000 rs78186690 chr7:135334991 G/C cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC trans rs72674100 1.000 rs2865754 chr4:97992711 T/C cg16405019 chr1:18959625 PAX7 -0.61 -6.43 -0.33 4.48e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7072216 0.727 rs3750603 chr10:100175536 A/T cg26618903 chr10:100175079 PYROXD2 -0.48 -8.96 -0.44 2.27e-17 Metabolite levels; LUSC trans rs208520 0.802 rs4710315 chr6:66887594 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -15.19 -0.64 5.5e-40 Exhaled nitric oxide output; LUSC cis rs10883723 0.962 rs1056738 chr10:104236481 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -7.4 -0.38 1.1e-12 Allergic disease (asthma, hay fever or eczema); LUSC trans rs35110281 0.807 rs2838326 chr21:45014315 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.98 0.44 2.01e-17 Mean corpuscular volume; LUSC cis rs7223966 1.000 rs7223672 chr17:61720565 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.78 0.35 5.34e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg12564285 chr5:131593104 PDLIM4 0.4 7.18 0.37 4.47e-12 Breast cancer; LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs1348850 0.632 rs11682717 chr2:178499240 C/G cg22681709 chr2:178499509 PDE11A -0.59 -11.89 -0.55 1.93e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg00857998 chr1:205179979 DSTYK 0.59 8.8 0.43 7.22e-17 Mean corpuscular volume;Mean platelet volume; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg19090637 chr4:111119052 ELOVL6 0.5 6.2 0.32 1.64e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs908922 0.743 rs10888499 chr1:152532742 C/A cg20991723 chr1:152506922 NA 0.5 8.4 0.42 1.28e-15 Hair morphology; LUSC cis rs1670533 1.000 rs4690215 chr4:1054619 G/C cg02018176 chr4:1364513 KIAA1530 0.44 6.11 0.32 2.78e-9 Recombination rate (females); LUSC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg26587870 chr6:27730563 NA -0.66 -5.94 -0.31 7.24e-9 Depression; LUSC cis rs11039100 1.000 rs12798823 chr11:5826716 T/G cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.54 -0.38 4.34e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9486715 1.000 rs6905737 chr6:97066659 A/T cg06623918 chr6:96969491 KIAA0776 -0.87 -14.2 -0.61 3.78e-36 Headache; LUSC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg07157834 chr1:205819609 PM20D1 0.43 5.98 0.31 5.73e-9 Parkinson's disease; LUSC cis rs7945718 0.805 rs6486059 chr11:12824581 A/G cg25843174 chr11:12811716 TEAD1 -0.31 -6.98 -0.36 1.57e-11 Educational attainment (years of education); LUSC cis rs7843479 0.931 rs1031883 chr8:21788936 G/A cg17168535 chr8:21777572 XPO7 0.67 10.25 0.49 1.33e-21 Mean corpuscular volume; LUSC cis rs354225 0.544 rs10193692 chr2:54808340 A/T cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg21724239 chr8:58056113 NA 0.58 6.96 0.36 1.85e-11 Developmental language disorder (linguistic errors); LUSC cis rs897984 0.806 rs9319588 chr16:30930983 C/T cg02466173 chr16:30829666 NA 0.56 11.19 0.52 6.77e-25 Dementia with Lewy bodies; LUSC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg03433033 chr1:76189801 ACADM 0.82 12.97 0.58 1.9e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2777491 0.915 rs28578057 chr15:41621921 G/A cg18705301 chr15:41695430 NDUFAF1 -0.73 -13.36 -0.59 6.47e-33 Ulcerative colitis; LUSC cis rs9840812 0.769 rs3755636 chr3:135968828 G/C cg15507776 chr3:136538369 TMEM22 0.45 6.21 0.32 1.54e-9 Fibrinogen levels; LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg05472934 chr7:22766657 IL6 0.5 7.76 0.39 1.03e-13 Lung cancer; LUSC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg17173187 chr15:85201210 NMB 0.37 6.56 0.34 2.08e-10 Schizophrenia; LUSC cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg11984989 chr7:158649758 WDR60 1.06 20.43 0.75 9.16e-61 Height; LUSC cis rs6582630 0.532 rs1589394 chr12:38419700 A/C cg13010199 chr12:38710504 ALG10B 0.51 7.63 0.39 2.46e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs977987 0.931 rs1834013 chr16:75496163 G/T cg04384234 chr16:75411784 CFDP1 -0.48 -7.96 -0.4 2.62e-14 Dupuytren's disease; LUSC cis rs27434 0.583 rs40091 chr5:96154919 A/G cg16492584 chr5:96139282 ERAP1 -0.58 -7.91 -0.4 3.9e-14 Ankylosing spondylitis; LUSC trans rs11098499 0.909 rs35111518 chr4:120440682 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.57 0.34 1.9e-10 Corneal astigmatism; LUSC cis rs1577917 0.958 rs11755048 chr6:86514334 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.56 -0.42 4.09e-16 Response to antipsychotic treatment; LUSC trans rs11700980 0.551 rs2832016 chr21:30111397 A/G cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg22782873 chr19:19639568 YJEFN3 -0.49 -6.12 -0.32 2.56e-9 Bipolar disorder; LUSC cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg18132916 chr6:79620363 NA -0.41 -6.2 -0.32 1.63e-9 Intelligence (multi-trait analysis); LUSC cis rs1577917 1.000 rs12196411 chr6:86779762 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.58 -0.42 3.69e-16 Response to antipsychotic treatment; LUSC cis rs1178127 0.580 rs17139840 chr7:18800603 T/C cg02370815 chr7:18831390 HDAC9 -0.4 -6.12 -0.32 2.59e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); LUSC cis rs11864453 0.560 rs6499561 chr16:72148404 A/G cg01557791 chr16:72042693 DHODH -0.48 -7.05 -0.36 1.02e-11 Fibrinogen levels; LUSC cis rs72781680 0.898 rs72786277 chr2:24062818 T/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg12639453 chr1:2035780 PRKCZ -0.35 -7.5 -0.38 5.99e-13 Height; LUSC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg09365446 chr1:150670422 GOLPH3L 0.46 7.02 0.36 1.24e-11 Melanoma; LUSC cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.84 -0.51 1.15e-23 Alzheimer's disease (late onset); LUSC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg06656553 chr16:89960601 TCF25 -0.65 -5.7 -0.3 2.65e-8 Skin colour saturation; LUSC cis rs12711979 0.509 rs13035992 chr2:3826597 G/A cg17052675 chr2:3827356 NA -0.83 -20.25 -0.74 4.69e-60 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs11583043 0.708 rs6577227 chr1:101562132 A/G cg11406453 chr1:101602562 NA -0.4 -6.72 -0.35 7.74e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg03806693 chr22:41940476 POLR3H -0.81 -11.79 -0.54 4.7e-27 Vitiligo; LUSC cis rs1729951 0.575 rs835641 chr3:136703474 G/T cg12473912 chr3:136751656 NA 0.4 7.12 0.36 6.46e-12 Neuroticism; LUSC cis rs6138458 1.000 rs6114981 chr20:24974401 C/T cg26195577 chr20:24973756 C20orf3 -1.09 -17.67 -0.7 8.42e-50 Blood protein levels; LUSC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg16339924 chr4:17578868 LAP3 0.57 8.63 0.43 2.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg22782873 chr19:19639568 YJEFN3 -0.49 -6.12 -0.32 2.56e-9 Bipolar disorder; LUSC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg12463550 chr7:65579703 CRCP 0.57 8.46 0.42 8.25e-16 Aortic root size; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg05564831 chr3:52568323 NT5DC2 -0.3 -5.65 -0.3 3.41e-8 Electroencephalogram traits; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg00770008 chr3:20081585 KAT2B 0.63 6.1 0.32 2.9e-9 Body mass index; LUSC cis rs7572644 0.640 rs11891769 chr2:28025580 G/C cg27432699 chr2:27873401 GPN1 0.56 7.32 0.37 1.84e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs10779751 0.734 rs2791649 chr1:11132561 A/G cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7819412 0.659 rs4073948 chr8:10772644 A/T cg27411982 chr8:10470053 RP1L1 -0.45 -6.63 -0.34 1.33e-10 Triglycerides; LUSC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg05132306 chr1:1846340 CALML6 -0.34 -8.51 -0.42 6.05e-16 Body mass index; LUSC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg14440974 chr22:39074834 NA 0.4 6.72 0.35 7.88e-11 Menopause (age at onset); LUSC cis rs77633900 0.772 rs79181196 chr15:76656281 G/T cg21673338 chr15:77095150 SCAPER -0.72 -6.18 -0.32 1.91e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs3857536 0.813 rs4710580 chr6:66935200 C/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs11893307 0.507 rs1465303 chr2:191585440 A/C cg11845111 chr2:191398756 TMEM194B -0.42 -5.7 -0.3 2.6e-8 Mean platelet volume; LUSC cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg25019033 chr10:957182 NA -0.48 -6.06 -0.31 3.73e-9 Eosinophil percentage of granulocytes; LUSC cis rs2980439 0.556 rs2921059 chr8:8317887 G/T cg15556689 chr8:8085844 FLJ10661 0.67 11.06 0.52 1.91e-24 Neuroticism; LUSC cis rs1185460 0.967 rs3825061 chr11:118944675 C/T cg23280166 chr11:118938394 VPS11 0.46 6.88 0.35 2.97e-11 Coronary artery disease; LUSC trans rs1347297 0.590 rs9288019 chr2:179276894 C/A cg14011486 chr1:26737247 LIN28 0.47 7.25 0.37 3.01e-12 Alzheimer disease and age of onset; LUSC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs9650657 0.645 rs4841408 chr8:10516336 A/G cg27411982 chr8:10470053 RP1L1 -0.48 -7.76 -0.39 1.07e-13 Neuroticism; LUSC cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.64 0.43 2.38e-16 Menopause (age at onset); LUSC cis rs600231 0.706 rs4244811 chr11:65320780 G/A cg21890820 chr11:65308645 LTBP3 -0.6 -8.6 -0.43 3.05e-16 Bone mineral density; LUSC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs3733585 0.699 rs6449172 chr4:9966036 A/T cg26043149 chr18:55253948 FECH -0.45 -6.92 -0.35 2.38e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9653442 0.545 rs4850921 chr2:100762699 G/T cg22139774 chr2:100720529 AFF3 -0.41 -7.06 -0.36 1e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4363385 0.818 rs1415965 chr1:153002750 G/A cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs9814567 0.762 rs13075332 chr3:134329836 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.85 12.0 0.55 8.1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7000551 0.725 rs2249098 chr8:22400098 T/C cg12081754 chr8:22256438 SLC39A14 0.44 6.42 0.33 4.71e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs7824557 0.564 rs2572395 chr8:11235360 A/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.43e-14 Retinal vascular caliber; LUSC cis rs4478858 0.662 rs6425735 chr1:31783945 T/C cg00250761 chr1:31883323 NA -0.36 -8.69 -0.43 1.61e-16 Alcohol dependence; LUSC cis rs9311676 0.656 rs68021431 chr3:58403136 A/G cg26110898 chr3:58419937 PDHB 0.39 6.34 0.33 7.61e-10 Systemic lupus erythematosus; LUSC cis rs2346177 0.844 rs13010062 chr2:46644137 C/G cg02822958 chr2:46747628 ATP6V1E2 0.36 6.23 0.32 1.38e-9 HDL cholesterol; LUSC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.15 0.41 7.24e-15 Bipolar disorder; LUSC trans rs61931739 0.534 rs2625897 chr12:34064295 G/A cg26384229 chr12:38710491 ALG10B 0.7 11.03 0.52 2.5e-24 Morning vs. evening chronotype; LUSC cis rs67478160 0.634 rs2368559 chr14:104230535 C/T cg01849466 chr14:104193079 ZFYVE21 -0.61 -10.38 -0.49 4.57e-22 Schizophrenia; LUSC cis rs6681460 0.932 rs618093 chr1:67178428 T/G cg02459107 chr1:67143332 SGIP1 0.47 8.82 0.43 6.64e-17 Presence of antiphospholipid antibodies; LUSC cis rs877282 0.755 rs11253399 chr10:790030 T/A cg17470449 chr10:769945 NA 0.42 6.32 0.33 8.54e-10 Uric acid levels; LUSC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.55 -0.42 4.48e-16 Personality dimensions; LUSC cis rs34526934 0.565 rs34729309 chr2:177034121 G/T cg26754761 chr2:177040938 NA -0.4 -7.72 -0.39 1.39e-13 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs12681287 0.640 rs4587306 chr8:87385511 T/C cg27223183 chr8:87520930 FAM82B 0.55 7.36 0.37 1.43e-12 Caudate activity during reward; LUSC trans rs11098499 0.754 rs17595608 chr4:120250506 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.4 0.33 5.2e-10 Corneal astigmatism; LUSC cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg03060546 chr3:49711283 APEH -0.68 -9.93 -0.48 1.59e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg00071950 chr4:10020882 SLC2A9 0.63 10.52 0.5 1.55e-22 Bone mineral density; LUSC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.13 -0.32 2.41e-9 Life satisfaction; LUSC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg08219700 chr8:58056026 NA 0.69 8.2 0.41 5.2e-15 Developmental language disorder (linguistic errors); LUSC cis rs950169 0.881 rs62029599 chr15:84956565 A/C cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.64e-15 Schizophrenia; LUSC cis rs929354 0.742 rs7806775 chr7:156947199 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC cis rs9911578 0.757 rs8081906 chr17:56631907 A/T cg12560992 chr17:57184187 TRIM37 -0.78 -12.49 -0.56 1.2e-29 Intelligence (multi-trait analysis); LUSC trans rs11700980 0.551 rs2409326 chr21:30109102 A/G cg14791747 chr16:20752902 THUMPD1 0.56 6.1 0.32 2.88e-9 QRS complex (12-leadsum); LUSC cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.99 0.36 1.48e-11 Rheumatoid arthritis; LUSC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg22437258 chr11:111473054 SIK2 0.53 7.49 0.38 6.36e-13 Primary sclerosing cholangitis; LUSC cis rs8030485 0.728 rs4778886 chr15:79389019 T/C cg17916960 chr15:79447300 NA 0.33 5.78 0.3 1.69e-8 Left ventricle wall thickness; LUSC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg16325326 chr1:53192061 ZYG11B -0.88 -16.25 -0.66 3.69e-44 Monocyte count; LUSC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg05368731 chr17:41323189 NBR1 0.92 15.4 0.64 8.61e-41 Menopause (age at onset); LUSC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg21951975 chr1:209979733 IRF6 -0.54 -8.17 -0.41 6.53e-15 Cleft lip with or without cleft palate; LUSC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg11764359 chr7:65958608 NA 0.49 6.34 0.33 7.3e-10 Aortic root size; LUSC cis rs11971779 0.680 rs6961812 chr7:139043808 A/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC trans rs8072100 0.967 rs9894905 chr17:45485982 C/T cg04995722 chr7:26192034 NFE2L3 -0.36 -5.94 -0.31 7.01e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2050392 0.544 rs598672 chr10:30742388 C/T cg18806716 chr10:30721971 MAP3K8 -0.6 -9.06 -0.44 1.09e-17 Inflammatory bowel disease; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg10360139 chr7:1886902 MAD1L1 0.38 5.68 0.3 2.88e-8 Bipolar disorder and schizophrenia; LUSC cis rs8017423 0.967 rs8015510 chr14:90729984 C/T cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.89 0.66 9.63e-43 Bladder cancer; LUSC cis rs728616 0.558 rs2343302 chr10:82163186 A/G cg05935833 chr10:81318306 SFTPA2 -0.44 -5.8 -0.3 1.57e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg06238570 chr21:40685208 BRWD1 -0.62 -10.32 -0.49 7.31e-22 Cognitive function; LUSC cis rs500891 0.525 rs9766300 chr6:84083733 T/A cg08257003 chr6:84140564 ME1 0.35 8.5 0.42 6.18e-16 Platelet-derived growth factor BB levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07590839 chr2:233415449 TIGD1;EIF4E2 0.71 6.01 0.31 4.94e-9 Cognitive performance; LUSC cis rs2742417 0.904 rs2373047 chr3:45747497 C/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.48e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs394563 0.601 rs376269 chr6:149795154 C/T cg11245181 chr6:149772854 ZC3H12D -0.34 -6.93 -0.35 2.23e-11 Dupuytren's disease; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg13397359 chr6:42928475 GNMT 0.57 9.41 0.46 8.34e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs75920871 0.528 rs7128772 chr11:116889411 T/A cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.42 -0.33 4.57e-10 Subjective well-being; LUSC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg04287289 chr16:89883240 FANCA -0.56 -8.68 -0.43 1.83e-16 Vitiligo; LUSC cis rs67072384 1.000 rs67072384 chr11:72450724 C/T cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.4e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.71 0.39 1.45e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6500602 0.702 rs2304634 chr16:4500544 C/T cg08645402 chr16:4508243 NA 0.52 8.77 0.43 9.43e-17 Schizophrenia; LUSC cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg01579765 chr21:45077557 HSF2BP 0.51 10.88 0.51 8.5e-24 Mean corpuscular volume; LUSC cis rs4919694 1.000 rs10509758 chr10:104681710 T/C cg23093090 chr10:104574429 C10orf26 -0.46 -5.74 -0.3 2.12e-8 Arsenic metabolism; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24815885 chr19:36486437 SDHAF1 -0.42 -6.05 -0.31 3.94e-9 Electrocardiographic conduction measures; LUSC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg11062466 chr8:58055876 NA 0.49 6.4 0.33 5.2e-10 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.909 rs6842762 chr4:120398236 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.58 0.34 1.77e-10 Corneal astigmatism; LUSC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg08677398 chr8:58056175 NA 0.52 6.62 0.34 1.46e-10 Developmental language disorder (linguistic errors); LUSC cis rs6599077 0.951 rs9860463 chr3:40094062 A/C cg13683864 chr3:40499215 RPL14 -0.55 -6.8 -0.35 4.77e-11 Sleep-related phenotypes; LUSC trans rs10097669 0.704 rs2725072 chr8:4439760 A/G cg16451306 chr5:71475356 MAP1B 0.29 6.03 0.31 4.43e-9 Trans fatty acid levels; LUSC cis rs10751667 0.666 rs7395321 chr11:940280 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.42 0.33 4.63e-10 Alzheimer's disease (late onset); LUSC cis rs757278 0.552 rs1594189 chr7:117311713 T/G cg10524701 chr7:117356490 CTTNBP2 0.4 5.75 0.3 1.99e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC trans rs12210905 0.843 rs12208039 chr6:26984004 C/A cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs7917772 0.582 rs729024 chr10:104341975 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg02951883 chr7:2050386 MAD1L1 -0.45 -8.04 -0.4 1.6e-14 Bipolar disorder and schizophrenia; LUSC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg26441486 chr22:50317300 CRELD2 0.52 7.98 0.4 2.42e-14 Schizophrenia; LUSC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg10117171 chr1:25599238 RHD -0.38 -5.86 -0.31 1.12e-8 Erythrocyte sedimentation rate; LUSC cis rs6939532 0.522 rs9358933 chr6:26363688 C/T cg09904177 chr6:26538194 HMGN4 -0.46 -6.68 -0.34 9.75e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs8062405 1.000 rs3088215 chr16:28853996 A/C cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10927875 1.000 rs3979179 chr1:16306846 A/G cg21385522 chr1:16154831 NA 0.77 12.05 0.55 5.23e-28 Dilated cardiomyopathy; LUSC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.46 0.38 7.64e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs4332037 1.000 rs10240470 chr7:1949971 G/T cg11693508 chr17:37793320 STARD3 -0.61 -7.55 -0.38 4.15e-13 Bipolar disorder; LUSC cis rs9303401 0.659 rs12602389 chr17:56779778 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs12908161 1.000 rs12910012 chr15:85298662 T/C cg12863693 chr15:85201151 NMB 0.41 8.48 0.42 7.34e-16 Schizophrenia; LUSC cis rs611744 0.647 rs11785776 chr8:109264933 C/T cg18478394 chr8:109455254 TTC35 0.42 6.57 0.34 1.93e-10 Dupuytren's disease; LUSC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg03709012 chr19:19516395 GATAD2A 0.86 14.57 0.62 1.42e-37 Tonsillectomy; LUSC cis rs2404602 0.622 rs1567671 chr15:77209200 C/G cg23625390 chr15:77176239 SCAPER -0.66 -10.02 -0.48 7.85e-21 Blood metabolite levels; LUSC cis rs17021463 0.966 rs1565062 chr4:95183000 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.4 -0.42 1.3e-15 Testicular germ cell tumor; LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8.19e-17 Bipolar disorder; LUSC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg16606324 chr3:10149918 C3orf24 0.44 6.78 0.35 5.34e-11 Alzheimer's disease; LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.63 0.39 2.5e-13 Bipolar disorder; LUSC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.02 -0.68 3.26e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18655958 chr19:48867355 TMEM143;SYNGR4 -0.44 -6.31 -0.33 8.63e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7771547 0.573 rs566742 chr6:36395668 C/T cg07856975 chr6:36356162 ETV7 0.33 5.92 0.31 8e-9 Platelet distribution width; LUSC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg12311346 chr5:56204834 C5orf35 -0.67 -9.93 -0.48 1.59e-20 Coronary artery disease; LUSC cis rs847577 0.508 rs12538837 chr7:97684468 C/T cg21770322 chr7:97807741 LMTK2 0.39 5.88 0.31 9.94e-9 Breast cancer; LUSC cis rs7312933 0.531 rs2708059 chr12:42851008 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.47 -6.68 -0.34 9.95e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24793903 chr17:45918221 SCRN2 -0.45 -6.12 -0.32 2.65e-9 Hepatitis; LUSC cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg16386425 chr10:429943 DIP2C -0.39 -5.72 -0.3 2.31e-8 Psychosis in Alzheimer's disease; LUSC cis rs1375194 0.558 rs13418410 chr2:33800899 C/A cg04131969 chr2:33951647 MYADML -0.62 -8.67 -0.43 1.92e-16 Response to antidepressants in depression; LUSC cis rs8072100 0.727 rs4794052 chr17:45769236 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.38 -6.32 -0.33 8.47e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs17533156 0.525 rs77932036 chr17:75207586 T/G cg11416367 chr17:75137675 SEC14L1 0.55 6.66 0.34 1.1e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.22 0.37 3.54e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -9.98 -0.48 1.09e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg11843238 chr5:131593191 PDLIM4 0.39 6.5 0.34 2.91e-10 Breast cancer; LUSC cis rs7824557 0.564 rs2736288 chr8:11228100 G/A cg27411982 chr8:10470053 RP1L1 -0.39 -6.02 -0.31 4.69e-9 Retinal vascular caliber; LUSC trans rs6502050 0.871 rs8082577 chr17:80070581 T/C cg07393940 chr7:158741817 NA -0.37 -6.51 -0.34 2.81e-10 Life satisfaction; LUSC cis rs11677416 1.000 rs1516789 chr2:113531024 C/T cg27083787 chr2:113543245 IL1A 0.48 7.54 0.38 4.51e-13 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg16362232 chr11:430036 ANO9 0.55 7.31 0.37 1.95e-12 Body mass index; LUSC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg23093090 chr10:104574429 C10orf26 -0.46 -8.36 -0.42 1.67e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg06600287 chr1:53387719 ECHDC2 -0.3 -6.12 -0.32 2.64e-9 Monocyte count; LUSC trans rs1994135 0.586 rs7308214 chr12:33713834 T/A cg13010199 chr12:38710504 ALG10B 0.51 7.14 0.36 5.95e-12 Resting heart rate; LUSC cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg00339695 chr16:24857497 SLC5A11 0.41 7.08 0.36 8.58e-12 Intelligence (multi-trait analysis); LUSC cis rs730566 1.000 rs4858819 chr3:48478088 C/T cg07636037 chr3:49044803 WDR6 -0.48 -6.39 -0.33 5.58e-10 Prion diseases; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06000050 chr6:119256092 MCM9 -0.49 -6.2 -0.32 1.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16780939 chr12:56753945 STAT2 0.4 6.09 0.32 3.12e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg12310025 chr6:25882481 NA -0.35 -5.79 -0.3 1.63e-8 Height; LUSC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg11644478 chr21:40555479 PSMG1 0.75 9.33 0.45 1.57e-18 Cognitive function; LUSC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs7615952 0.546 rs2922194 chr3:125332263 G/A cg05084668 chr3:125655381 ALG1L -0.47 -5.88 -0.31 9.98e-9 Blood pressure (smoking interaction); LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg12963246 chr6:28129442 ZNF389 0.58 8.07 0.4 1.24e-14 Parkinson's disease; LUSC cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg02807482 chr3:125708958 NA -0.52 -6.55 -0.34 2.23e-10 Blood pressure (smoking interaction); LUSC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.58 -7.41 -0.38 1.07e-12 Glomerular filtration rate in chronic kidney disease; LUSC cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg22709100 chr7:91322751 NA -0.39 -5.66 -0.3 3.24e-8 Breast cancer; LUSC cis rs6539267 0.923 rs4964175 chr12:106753984 A/G cg00173435 chr12:106696525 TCP11L2 -0.44 -6.21 -0.32 1.56e-9 Tourette syndrome; LUSC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg09650180 chr20:62225654 GMEB2 -0.66 -9.52 -0.46 3.73e-19 Glioblastoma; LUSC cis rs1018836 0.527 rs13268721 chr8:91481549 G/A cg16814680 chr8:91681699 NA -0.68 -10.33 -0.49 6.66e-22 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs11696501 0.688 rs6065859 chr20:44302697 C/T cg03272292 chr12:48577362 C12orf68 0.5 6.1 0.32 2.93e-9 Brain structure; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02894226 chr20:3190561 ITPA 0.46 6.8 0.35 4.82e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg27539214 chr16:67997921 SLC12A4 -0.46 -5.95 -0.31 6.69e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg11812906 chr14:75593930 NEK9 0.64 10.58 0.5 9.58e-23 Height; LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg07703079 chr11:430292 ANO9 -0.64 -7.0 -0.36 1.42e-11 Body mass index; LUSC cis rs9311676 0.656 rs11714807 chr3:58405431 A/G cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.3e-10 Systemic lupus erythematosus; LUSC cis rs10740039 0.883 rs10443929 chr10:62405610 C/G cg18175470 chr10:62150864 ANK3 -0.46 -6.86 -0.35 3.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC cis rs7772486 0.846 rs1474871 chr6:146406294 G/A cg13319975 chr6:146136371 FBXO30 -0.47 -6.92 -0.35 2.32e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg26597838 chr10:835615 NA 1.21 16.6 0.67 1.46e-45 Eosinophil percentage of granulocytes; LUSC trans rs11098499 0.754 rs7689729 chr4:120256192 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.34e-10 Corneal astigmatism; LUSC cis rs4631830 0.747 rs745180 chr10:51504493 A/C cg20129853 chr10:51489980 NA 0.35 7.27 0.37 2.63e-12 Prostate-specific antigen levels; LUSC cis rs4841097 0.876 rs6601288 chr8:8943430 A/T cg06636001 chr8:8085503 FLJ10661 0.4 5.77 0.3 1.85e-8 Platelet distribution width; LUSC cis rs1801251 1.000 rs7587309 chr2:233705702 G/T cg25237894 chr2:233734115 C2orf82 -0.36 -6.63 -0.34 1.38e-10 Coronary artery disease; LUSC cis rs12900413 0.673 rs35308090 chr15:90308026 G/T cg24249390 chr15:90295951 MESP1 -0.37 -5.92 -0.31 7.96e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs3087591 0.708 rs10438801 chr17:29693785 G/A cg24425628 chr17:29625626 OMG;NF1 0.47 7.0 0.36 1.43e-11 Hip circumference; LUSC cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg01579765 chr21:45077557 HSF2BP -0.57 -12.34 -0.56 4.57e-29 Mean corpuscular volume; LUSC cis rs7246967 0.673 rs34003335 chr19:22925602 T/C cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -6.58 -0.34 1.79e-10 Developmental language disorder (linguistic errors); LUSC cis rs16937 0.711 rs10900465 chr1:205158183 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs9815354 0.812 rs766286 chr3:41838329 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1395 1.000 rs1275538 chr2:27441397 C/T cg23587288 chr2:27483067 SLC30A3 -0.27 -5.75 -0.3 2.06e-8 Blood metabolite levels; LUSC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 13.43 0.59 3.62e-33 Allergic disease (asthma, hay fever or eczema); LUSC cis rs5758511 0.817 rs133291 chr22:42269628 C/T cg00645731 chr22:42541494 CYP2D7P1 0.47 8.17 0.41 6.51e-15 Birth weight; LUSC cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs950169 0.545 rs4354897 chr15:84644971 T/C cg17173187 chr15:85201210 NMB 0.36 5.96 0.31 6.46e-9 Schizophrenia; LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg24060327 chr5:131705240 SLC22A5 -0.67 -11.41 -0.53 1.13e-25 Breast cancer; LUSC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs12950390 0.853 rs12450729 chr17:45855363 A/G cg03474202 chr17:45855739 NA -0.29 -6.62 -0.34 1.44e-10 IgG glycosylation; LUSC cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg05868516 chr6:26286170 HIST1H4H 0.36 5.76 0.3 1.89e-8 Educational attainment; LUSC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg03517284 chr6:25882590 NA 0.39 6.63 0.34 1.37e-10 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg27170947 chr2:26402098 FAM59B -0.64 -9.35 -0.46 1.31e-18 Gut microbiome composition (summer); LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg16393715 chr7:1948819 MAD1L1 0.4 6.94 0.36 2.04e-11 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg13683864 chr3:40499215 RPL14 -0.95 -16.55 -0.67 2.31e-45 Renal cell carcinoma; LUSC cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg08213375 chr14:104286397 PPP1R13B 0.45 8.18 0.41 6.17e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg15704280 chr7:45808275 SEPT13 0.94 13.51 0.59 1.74e-33 Coronary artery disease; LUSC cis rs5758511 0.680 rs17002902 chr22:42625509 C/G cg12850546 chr22:42539477 CYP2D7P1 -0.47 -5.83 -0.3 1.31e-8 Birth weight; LUSC cis rs1577917 0.958 rs9647601 chr6:86449827 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.72 -0.43 1.36e-16 Response to antipsychotic treatment; LUSC cis rs240764 0.658 rs12664626 chr6:101195720 A/G cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.8 0.39 8.08e-14 Major depressive disorder; LUSC trans rs877282 1.000 rs71494928 chr10:769134 A/G cg22713356 chr15:30763199 NA 1.09 15.55 0.65 2.2e-41 Uric acid levels; LUSC cis rs9911578 0.867 rs4793941 chr17:56472366 G/A cg12560992 chr17:57184187 TRIM37 -0.69 -12.34 -0.56 4.35e-29 Intelligence (multi-trait analysis); LUSC cis rs12220238 0.915 rs1908334 chr10:75991721 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.07 0.36 9.33e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg03146154 chr1:46216737 IPP 0.51 7.68 0.39 1.8e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8060686 0.516 rs255052 chr16:68024995 C/T cg05110241 chr16:68378359 PRMT7 -0.56 -6.58 -0.34 1.84e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14607904 chr6:170862125 PSMB1;TBP 0.5 7.61 0.38 2.89e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.563 rs17092980 chr20:34289005 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.64 -0.43 2.38e-16 Total cholesterol levels; LUSC cis rs1790761 0.692 rs10444362 chr11:67333090 G/A cg14500267 chr11:67383377 NA 0.33 6.33 0.33 7.89e-10 Mean corpuscular volume; LUSC cis rs870825 0.860 rs11132253 chr4:185595472 C/T cg04058563 chr4:185651563 MLF1IP 0.71 10.38 0.49 4.61e-22 Blood protein levels; LUSC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg17279839 chr7:150038598 RARRES2 0.54 8.09 0.4 1.08e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs2455601 0.529 rs2653569 chr11:8986978 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.45 -7.16 -0.36 5.29e-12 Schizophrenia; LUSC cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg00152838 chr16:24741724 TNRC6A -0.48 -5.97 -0.31 6.05e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs9653442 0.900 rs1160544 chr2:100832218 A/C cg07810366 chr2:100720526 AFF3 -0.48 -8.19 -0.41 5.68e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6906287 0.647 rs13192574 chr6:118875258 C/T cg21191810 chr6:118973309 C6orf204 0.33 6.04 0.31 4.16e-9 Electrocardiographic conduction measures; LUSC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg09835421 chr16:68378352 PRMT7 -0.5 -5.72 -0.3 2.39e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs62432291 0.681 rs378339 chr6:159658852 C/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.47 6.82 0.35 4.18e-11 Schizophrenia; LUSC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.83 0.39 6.38e-14 Parkinson's disease; LUSC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg08859206 chr1:53392774 SCP2 0.37 6.15 0.32 2.2e-9 Monocyte count; LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg25767906 chr1:53392781 SCP2 -0.47 -8.01 -0.4 1.94e-14 Monocyte count; LUSC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.62 10.27 0.49 1.07e-21 Lymphocyte counts; LUSC cis rs1595825 0.891 rs7573687 chr2:198893376 A/G cg00982548 chr2:198649783 BOLL -0.54 -6.93 -0.35 2.2e-11 Ulcerative colitis; LUSC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.16 0.36 5.2e-12 Mean platelet volume; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg16357287 chr18:12947517 SEH1L 0.39 6.04 0.31 4.09e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs1790761 0.967 rs7479801 chr11:67213748 G/T cg24690094 chr11:67383802 NA -0.33 -6.05 -0.31 3.86e-9 Mean corpuscular volume; LUSC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg11608241 chr8:8085544 FLJ10661 0.53 7.79 0.39 8.29e-14 Neuroticism; LUSC cis rs425277 0.958 rs262687 chr1:2117155 G/A cg24578937 chr1:2090814 PRKCZ 0.61 13.83 0.6 1.01e-34 Height; LUSC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.49 -0.53 5.85e-26 Schizophrenia; LUSC trans rs9329221 0.510 rs6995837 chr8:9975675 T/C cg21775007 chr8:11205619 TDH 0.43 6.04 0.31 4.1e-9 Neuroticism; LUSC cis rs9517320 0.935 rs9645891 chr13:99126800 A/G cg20487152 chr13:99095054 FARP1 0.35 6.45 0.33 3.86e-10 Longevity; LUSC cis rs7677751 0.806 rs4864861 chr4:55097685 C/T cg17187183 chr4:55093834 PDGFRA 0.39 5.78 0.3 1.72e-8 Corneal astigmatism; LUSC cis rs7089973 0.668 rs61868024 chr10:116637939 A/G cg23260525 chr10:116636907 FAM160B1 0.42 8.54 0.42 4.79e-16 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4919087 0.810 rs1572437 chr10:99029278 A/G cg25902810 chr10:99078978 FRAT1 0.5 7.01 0.36 1.32e-11 Monocyte count; LUSC trans rs10851478 0.872 rs925104 chr15:49916655 T/G cg23074453 chr15:44487924 FRMD5 -0.33 -6.08 -0.32 3.26e-9 Oral cavity cancer; LUSC cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.19 0.52 6.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg01802117 chr1:53393560 SCP2 0.36 5.95 0.31 6.65e-9 Monocyte count; LUSC cis rs5769765 0.773 rs138861 chr22:50202276 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.44 6.55 0.34 2.14e-10 Schizophrenia; LUSC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg18681998 chr4:17616180 MED28 0.9 17.84 0.7 1.85e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg04369109 chr6:150039330 LATS1 -0.58 -8.5 -0.42 6.24e-16 Lung cancer; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.08e-17 Prudent dietary pattern; LUSC cis rs10761482 0.861 rs10821730 chr10:62099271 A/T cg18175470 chr10:62150864 ANK3 0.47 6.76 0.35 6.34e-11 Schizophrenia; LUSC cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.47 -7.23 -0.37 3.34e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.38 -0.37 1.28e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg24733560 chr20:60626293 TAF4 0.39 6.42 0.33 4.73e-10 Body mass index; LUSC cis rs7824557 0.872 rs2572417 chr8:11111462 A/T cg21775007 chr8:11205619 TDH -0.57 -9.0 -0.44 1.69e-17 Retinal vascular caliber; LUSC cis rs1712517 0.873 rs7894240 chr10:105000369 T/C cg05636881 chr10:105038444 INA -0.37 -6.17 -0.32 2.01e-9 Migraine; LUSC cis rs2798269 1.000 rs7990030 chr13:22123819 T/C cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.1 -0.32 2.93e-9 PR segment; LUSC trans rs10435719 0.764 rs10103485 chr8:11787563 C/T cg15556689 chr8:8085844 FLJ10661 0.57 8.65 0.43 2.19e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs11098499 0.863 rs1480940 chr4:120457682 T/C cg25214090 chr10:38739885 LOC399744 0.53 7.69 0.39 1.71e-13 Corneal astigmatism; LUSC cis rs12950390 0.893 rs4239165 chr17:45847272 A/T cg06532163 chr17:45867833 NA 0.34 6.22 0.32 1.5e-9 IgG glycosylation; LUSC cis rs7524258 0.900 rs6689574 chr1:7288534 C/G cg07173049 chr1:7289937 CAMTA1 0.36 7.34 0.37 1.67e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs10875746 0.807 rs12297004 chr12:48453820 A/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.69 -0.3 2.77e-8 Longevity (90 years and older); LUSC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg18876405 chr7:65276391 NA 0.55 8.81 0.43 6.74e-17 Aortic root size; LUSC cis rs56161922 1.000 rs41274776 chr1:207812791 A/G cg11752769 chr1:207818423 CR1L -0.69 -5.72 -0.3 2.31e-8 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs2522056 1.000 rs886286 chr5:131795597 A/G cg24060327 chr5:131705240 SLC22A5 0.45 5.96 0.31 6.39e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg12257692 chr3:49977190 RBM6 -0.25 -7.08 -0.36 8.82e-12 Intelligence (multi-trait analysis); LUSC cis rs7719624 0.869 rs6893691 chr5:135395433 A/G cg12897067 chr5:135418308 NA 0.42 6.05 0.31 3.91e-9 Response to cytidine analogues (gemcitabine); LUSC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg25282410 chr6:160211355 TCP1;MRPL18 1.07 16.07 0.66 1.81e-43 Age-related macular degeneration (geographic atrophy); LUSC cis rs3008870 1.000 rs3008858 chr1:67390416 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.16 0.64 7.32e-40 Lymphocyte percentage of white cells; LUSC cis rs7804356 1.000 rs73067475 chr7:26857120 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs17270561 0.609 rs4712963 chr6:25740502 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.61 0.38 2.9e-13 Iron status biomarkers; LUSC cis rs6582630 0.533 rs11181379 chr12:38332381 C/T cg13010199 chr12:38710504 ALG10B 0.48 7.24 0.37 3.1e-12 Drug-induced liver injury (flucloxacillin); LUSC cis rs9905704 0.918 rs304272 chr17:56803028 C/A cg12560992 chr17:57184187 TRIM37 0.56 8.01 0.4 1.92e-14 Testicular germ cell tumor; LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 10.09 0.48 4.6e-21 Bipolar disorder; LUSC cis rs6867032 0.527 rs13162781 chr5:2012235 C/T cg26168224 chr5:2018326 NA 0.59 10.09 0.48 4.65e-21 Gut microbiome composition (winter); LUSC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg25204440 chr1:209979598 IRF6 0.49 6.51 0.34 2.81e-10 Cleft lip with or without cleft palate; LUSC cis rs6456156 0.586 rs2345753 chr6:167484344 T/A cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs4925325 0.915 rs2427246 chr20:60517047 T/C cg23262073 chr20:60523788 NA -0.63 -9.15 -0.45 5.81e-18 Obesity-related traits; LUSC cis rs713477 0.654 rs6573030 chr14:55913720 T/G cg13175173 chr14:55914753 NA -0.29 -5.98 -0.31 5.71e-9 Pediatric bone mineral content (femoral neck); LUSC trans rs17076896 0.881 rs36213078 chr13:19757540 G/C cg01891818 chr17:73008509 ICT1 0.5 6.17 0.32 1.97e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs8032315 0.965 rs4932373 chr15:91429287 A/C cg06330618 chr15:91428456 FES 0.28 5.73 0.3 2.25e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs17780086 0.527 rs17182651 chr17:30547537 G/A cg00745463 chr17:30367425 LRRC37B -0.79 -7.7 -0.39 1.54e-13 Height; LUSC cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 7.55 0.38 4.18e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg09665592 chr9:130699885 DPM2 -0.47 -6.14 -0.32 2.36e-9 Hepatitis; LUSC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg02423579 chr7:2872169 GNA12 -0.49 -6.97 -0.36 1.72e-11 Height; LUSC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18404041 chr3:52824283 ITIH1 -0.48 -9.13 -0.45 6.49e-18 Electroencephalogram traits; LUSC cis rs6546550 0.935 rs2168115 chr2:70034793 A/G cg02498382 chr2:70120550 SNRNP27 -0.28 -6.76 -0.35 6.09e-11 Prevalent atrial fibrillation; LUSC cis rs11971779 0.680 rs6954531 chr7:139054706 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs6696846 0.765 rs61822565 chr1:205077332 T/C cg21643547 chr1:205240462 TMCC2 -0.42 -7.65 -0.39 2.15e-13 Red blood cell count; LUSC cis rs12681288 0.862 rs7814070 chr8:1020991 A/G cg04851639 chr8:1020857 NA -0.39 -8.21 -0.41 4.82e-15 Schizophrenia; LUSC cis rs9486719 1.000 rs10457159 chr6:96993139 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.74 -0.47 6.99e-20 Migraine;Coronary artery disease; LUSC cis rs7903847 0.642 rs11189180 chr10:99143529 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.3 -0.37 2.19e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg03146154 chr1:46216737 IPP -0.53 -7.86 -0.39 5.5e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg01097406 chr16:89675127 NA 0.33 6.36 0.33 6.79e-10 Vitiligo; LUSC cis rs11155671 0.530 rs4458704 chr6:150232879 A/C cg13206674 chr6:150067644 NUP43 0.46 6.84 0.35 3.73e-11 Testicular germ cell tumor; LUSC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg26380479 chr7:97908229 NA -0.27 -6.14 -0.32 2.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg26384229 chr12:38710491 ALG10B 0.63 10.07 0.48 5.38e-21 Morning vs. evening chronotype; LUSC cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg06026331 chr20:60912101 LAMA5 -0.52 -6.24 -0.32 1.29e-9 Colorectal cancer; LUSC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg22920501 chr2:26401640 FAM59B -0.75 -10.68 -0.5 4.33e-23 Gut microbiome composition (summer); LUSC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2486288 0.656 rs11637838 chr15:45550657 A/G cg26924012 chr15:45694286 SPATA5L1 -0.71 -10.56 -0.5 1.12e-22 Glomerular filtration rate; LUSC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg09085632 chr11:111637200 PPP2R1B -0.97 -13.89 -0.61 5.98e-35 Primary sclerosing cholangitis; LUSC trans rs11700980 0.551 rs2832015 chr21:30111192 G/T cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg07716408 chr11:68623521 NA -0.31 -5.94 -0.31 7.27e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.34 6.16 0.32 2.13e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1003719 0.715 rs2835675 chr21:38582815 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -9.98 -0.48 1.08e-20 Eye color traits; LUSC cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.65 0.65 8.39e-42 Bladder cancer; LUSC cis rs7208859 0.623 rs28627615 chr17:29145817 G/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs10465746 0.725 rs10127737 chr1:84368642 G/A cg10977910 chr1:84465055 TTLL7 0.51 7.34 0.37 1.69e-12 Obesity-related traits; LUSC cis rs7584330 0.955 rs7581882 chr2:238390745 T/C cg14458575 chr2:238380390 NA 0.68 11.58 0.54 2.63e-26 Prostate cancer; LUSC cis rs826838 0.967 rs826870 chr12:39120250 G/A cg26384229 chr12:38710491 ALG10B -0.84 -15.73 -0.65 4.2e-42 Heart rate; LUSC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC trans rs10435719 0.780 rs9692662 chr8:11789863 C/T cg15556689 chr8:8085844 FLJ10661 0.58 8.71 0.43 1.44e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg11764359 chr7:65958608 NA 0.81 13.62 0.6 6.38e-34 Aortic root size; LUSC trans rs853679 0.824 rs34712084 chr6:28043828 A/G cg01620082 chr3:125678407 NA -0.57 -6.28 -0.32 1.05e-9 Depression; LUSC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs523522 0.962 rs9040 chr12:120900274 C/T cg27279351 chr12:120934652 DYNLL1 0.62 8.37 0.42 1.6e-15 High light scatter reticulocyte count; LUSC cis rs2639990 1.000 rs1702831 chr18:72897368 C/A cg02750262 chr18:72916776 ZADH2 0.64 7.46 0.38 7.33e-13 Vascular endothelial growth factor levels; LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg08280861 chr8:58055591 NA 0.56 6.05 0.31 3.96e-9 Developmental language disorder (linguistic errors); LUSC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg14440974 chr22:39074834 NA -0.4 -6.56 -0.34 2.09e-10 Menopause (age at onset); LUSC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg00031303 chr3:195681400 NA -0.45 -7.04 -0.36 1.13e-11 Bronchopulmonary dysplasia; LUSC cis rs9457247 0.510 rs6456151 chr6:167471851 A/C cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Crohn's disease; LUSC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg24829409 chr8:58192753 C8orf71 -0.55 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC trans rs61931739 1.000 rs1852223 chr12:34013251 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.97 -0.31 5.95e-9 Morning vs. evening chronotype; LUSC cis rs1577917 0.958 rs7382798 chr6:86559834 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg20203395 chr5:56204925 C5orf35 -0.87 -11.74 -0.54 7.07e-27 Initial pursuit acceleration; LUSC cis rs3768617 0.510 rs10797837 chr1:183075121 C/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.81 0.51 1.45e-23 Fuchs's corneal dystrophy; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg07797438 chr19:37019581 ZNF260 0.43 6.49 0.33 3.04e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs80130819 0.688 rs2732476 chr12:48700691 T/C cg24011408 chr12:48396354 COL2A1 0.46 6.11 0.32 2.72e-9 Prostate cancer; LUSC cis rs6121246 0.909 rs1994250 chr20:30287494 A/G cg18721089 chr20:30220636 NA -0.35 -5.98 -0.31 5.83e-9 Mean corpuscular hemoglobin; LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg13685833 chr1:53393034 SCP2 0.41 6.33 0.33 7.98e-10 Monocyte count; LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg23161317 chr6:28129485 ZNF389 0.44 5.67 0.3 3.05e-8 Parkinson's disease; LUSC cis rs3741151 0.892 rs2027761 chr11:73036179 C/T cg17517138 chr11:73019481 ARHGEF17 0.93 8.9 0.44 3.51e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7843479 0.582 rs11779655 chr8:21794041 A/G cg17168535 chr8:21777572 XPO7 -0.82 -15.98 -0.66 4.34e-43 Mean corpuscular volume; LUSC cis rs2230307 0.536 rs11166385 chr1:100443462 A/G cg24955406 chr1:100503596 HIAT1 0.56 6.04 0.31 4.01e-9 Carotid intima media thickness; LUSC cis rs6076065 0.723 rs6132607 chr20:23390373 C/G cg11657817 chr20:23433608 CST11 -0.42 -7.76 -0.39 1.04e-13 Facial morphology (factor 15, philtrum width); LUSC cis rs1728785 1.000 rs6499181 chr16:68593002 A/T cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.45e-10 Ulcerative colitis; LUSC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg08704250 chr15:31115839 NA -0.57 -8.75 -0.43 1.08e-16 Huntington's disease progression; LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.66 0.65 8.05e-42 Platelet count; LUSC cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg01849466 chr14:104193079 ZFYVE21 0.56 8.47 0.42 7.82e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg09796270 chr17:17721594 SREBF1 0.39 7.06 0.36 9.9e-12 Total body bone mineral density; LUSC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg24531977 chr5:56204891 C5orf35 -1.05 -15.1 -0.64 1.27e-39 Initial pursuit acceleration; LUSC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg12463550 chr7:65579703 CRCP -0.5 -7.29 -0.37 2.19e-12 Aortic root size; LUSC cis rs6547741 0.844 rs7382 chr2:27873415 G/A cg12559939 chr2:27858050 GPN1 -0.4 -6.18 -0.32 1.82e-9 Oral cavity cancer; LUSC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg14552801 chr7:65878734 NA 0.38 5.8 0.3 1.51e-8 Aortic root size; LUSC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.83 -0.39 6.56e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.23 -0.32 1.37e-9 Breast cancer; LUSC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC trans rs6951245 0.745 rs79788515 chr7:1101079 C/T cg13565492 chr6:43139072 SRF -0.61 -6.48 -0.33 3.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10992471 0.580 rs10992304 chr9:95085365 G/A cg14631576 chr9:95140430 CENPP -0.38 -6.44 -0.33 4.19e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg18110333 chr6:292329 DUSP22 -0.53 -8.02 -0.4 1.83e-14 Menopause (age at onset); LUSC trans rs7980799 0.653 rs1384598 chr12:33622899 T/A cg26384229 chr12:38710491 ALG10B -0.58 -8.7 -0.43 1.5e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg04166393 chr7:2884313 GNA12 0.46 6.11 0.32 2.74e-9 Height; LUSC cis rs7647973 1.000 rs7648995 chr3:49438803 C/T cg07636037 chr3:49044803 WDR6 -0.69 -9.2 -0.45 4.05e-18 Menarche (age at onset); LUSC cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg27279351 chr12:120934652 DYNLL1 0.63 8.35 0.42 1.8e-15 High light scatter reticulocyte count; LUSC cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs55910451 0.779 rs72774077 chr10:5768089 G/A cg11519256 chr10:5708881 ASB13 -0.47 -5.7 -0.3 2.61e-8 Breast cancer; LUSC trans rs1027479 0.813 rs3019344 chr8:109723707 T/C cg14904725 chr13:113777045 F10 -0.26 -6.18 -0.32 1.84e-9 Facial morphology (factor 6, height of vermillion lower lip); LUSC cis rs6469656 0.803 rs10112279 chr8:117716963 T/C cg24004040 chr8:117650383 NA -0.44 -6.3 -0.33 9.5e-10 Colorectal cancer; LUSC trans rs61931739 0.500 rs7489270 chr12:34432062 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.77 0.51 2.01e-23 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs11264213 0.686 rs645383 chr1:36373823 C/G cg27506609 chr1:36549197 TEKT2 -0.58 -8.32 -0.41 2.33e-15 Schizophrenia; LUSC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg05855489 chr10:104503620 C10orf26 0.56 8.52 0.42 5.53e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6964587 1.000 rs10270598 chr7:91700827 T/C cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs10504229 0.516 rs1866994 chr8:57990092 A/C cg22535103 chr8:58192502 C8orf71 -0.48 -6.41 -0.33 4.99e-10 Developmental language disorder (linguistic errors); LUSC cis rs16976116 0.901 rs8028525 chr15:55492317 T/C cg11288833 chr15:55489084 RSL24D1 0.5 5.88 0.31 1.02e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4280164 0.551 rs12436194 chr14:24804859 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.61 -7.51 -0.38 5.37e-13 Parent of origin effect on language impairment (paternal); LUSC cis rs763121 0.962 rs2071887 chr22:38879010 A/T cg06022373 chr22:39101656 GTPBP1 0.64 10.11 0.48 3.84e-21 Menopause (age at onset); LUSC cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.8 8.21 0.41 5.03e-15 Initial pursuit acceleration; LUSC cis rs9815354 0.812 rs56183581 chr3:41848492 C/T cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs752010 0.543 rs1570355 chr1:42042317 C/T cg06885757 chr1:42089581 HIVEP3 0.34 6.87 0.35 3.1e-11 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7264396 0.563 rs6058296 chr20:34269225 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -8.58 -0.43 3.5e-16 Total cholesterol levels; LUSC trans rs9951602 0.512 rs58352488 chr18:76651113 T/A cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC cis rs501916 0.634 rs1561482 chr15:48069663 G/A cg16110827 chr15:48056943 SEMA6D -0.38 -6.01 -0.31 4.9e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs9399135 0.967 rs4388304 chr6:135309597 T/A cg24558204 chr6:135376177 HBS1L 0.59 9.13 0.45 6.87e-18 Red blood cell count; LUSC cis rs4903214 0.895 rs10130040 chr14:74713682 A/C cg08255017 chr14:74727001 VSX2 -0.52 -7.3 -0.37 2.17e-12 Inflammatory bowel disease; LUSC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.97 19.44 0.73 7.71e-57 Body mass index (adult); LUSC cis rs9303280 0.901 rs2313430 chr17:37929816 T/C cg20243544 chr17:37824526 PNMT -0.4 -6.07 -0.32 3.43e-9 Self-reported allergy; LUSC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg18876405 chr7:65276391 NA -0.55 -8.58 -0.43 3.53e-16 Aortic root size; LUSC cis rs73416724 0.920 rs76088627 chr6:43311851 G/A cg26312998 chr6:43337775 ZNF318 0.57 6.69 0.34 9.53e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg04398451 chr17:18023971 MYO15A -0.5 -8.0 -0.4 2.12e-14 Total body bone mineral density; LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg04267008 chr7:1944627 MAD1L1 -0.56 -8.39 -0.42 1.38e-15 Bipolar disorder and schizophrenia; LUSC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.9 -0.55 1.77e-27 Extrinsic epigenetic age acceleration; LUSC cis rs501916 0.761 rs589889 chr15:48019016 C/G cg16110827 chr15:48056943 SEMA6D -0.41 -6.51 -0.34 2.69e-10 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs10144321 0.729 rs2273802 chr14:100842899 G/A cg14882082 chr14:100845427 WDR25 -0.4 -7.5 -0.38 5.97e-13 Menarche (age at onset); LUSC cis rs61931739 0.500 rs7309931 chr12:34483471 A/C cg06521331 chr12:34319734 NA -0.41 -6.73 -0.35 7.4e-11 Morning vs. evening chronotype; LUSC cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg25173405 chr17:45401733 C17orf57 0.39 6.18 0.32 1.86e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.16 -0.45 5.53e-18 Schizophrenia; LUSC cis rs9309473 0.687 rs10165862 chr2:73610743 C/T cg20560298 chr2:73613845 ALMS1 -0.55 -7.95 -0.4 2.85e-14 Metabolite levels; LUSC cis rs11997175 0.766 rs4442096 chr8:33691039 T/C ch.8.33884649F chr8:33765107 NA 0.4 6.15 0.32 2.22e-9 Body mass index; LUSC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg16339924 chr4:17578868 LAP3 -0.54 -8.25 -0.41 3.78e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9790314 0.934 rs9290074 chr3:160997823 T/C cg03342759 chr3:160939853 NMD3 -0.5 -8.44 -0.42 9.97e-16 Morning vs. evening chronotype; LUSC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg26566898 chr11:117069891 TAGLN 0.48 8.57 0.42 3.81e-16 Blood protein levels; LUSC cis rs6722750 0.783 rs11125991 chr2:64387765 A/G cg22352474 chr2:64371530 PELI1 0.63 9.98 0.48 1.07e-20 Neuroticism; LUSC cis rs9462027 0.630 rs2744943 chr6:34643179 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.21 -0.32 1.53e-9 Systemic lupus erythematosus; LUSC cis rs2303282 0.664 rs4924 chr16:56396486 C/T cg00500540 chr16:56394104 NA -0.39 -6.73 -0.35 7.2e-11 Breast cancer; LUSC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg13206674 chr6:150067644 NUP43 0.59 9.22 0.45 3.31e-18 Lung cancer; LUSC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg05347473 chr6:146136440 FBXO30 0.56 9.77 0.47 5.24e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg27572855 chr1:25598939 RHD 0.46 8.36 0.42 1.69e-15 Plateletcrit;Mean corpuscular volume; LUSC cis rs55665837 1.000 rs10047457 chr11:14439459 T/A cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg08847533 chr14:75593920 NEK9 -0.79 -13.49 -0.59 2.12e-33 Height; LUSC cis rs17401966 0.964 rs6674843 chr1:10458378 A/T cg19773385 chr1:10388646 KIF1B -0.51 -7.42 -0.38 9.95e-13 Hepatocellular carcinoma; LUSC cis rs2235649 0.833 rs9929264 chr16:1851934 T/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.42 -6.02 -0.31 4.48e-9 Blood metabolite levels; LUSC cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3126085 0.877 rs868304 chr1:152178568 G/A cg26876637 chr1:152193138 HRNR 0.43 6.11 0.32 2.84e-9 Atopic dermatitis; LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg11843238 chr5:131593191 PDLIM4 -0.39 -6.46 -0.33 3.8e-10 Breast cancer; LUSC trans rs7294372 1.000 rs11834213 chr12:114591550 C/T cg21542643 chr7:99425614 CYP3A43 -0.54 -6.11 -0.32 2.85e-9 Visceral fat; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg08888203 chr3:10149979 C3orf24 0.63 8.32 0.41 2.32e-15 Alzheimer's disease; LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg12432903 chr7:1882776 MAD1L1 -0.36 -5.79 -0.3 1.67e-8 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2404602 0.503 rs284909 chr15:76736628 C/T cg26408565 chr15:76604113 ETFA -0.38 -5.89 -0.31 9.21e-9 Blood metabolite levels; LUSC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7843479 0.965 rs11775479 chr8:21859991 C/T cg17168535 chr8:21777572 XPO7 0.66 9.73 0.47 7.39e-20 Mean corpuscular volume; LUSC cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg00071950 chr4:10020882 SLC2A9 0.66 11.13 0.52 1.11e-24 Bone mineral density; LUSC cis rs1506636 0.962 rs10273985 chr7:123309538 A/T cg03229431 chr7:123269106 ASB15 -0.65 -10.68 -0.5 4.12e-23 Plateletcrit;Platelet count; LUSC cis rs12776158 0.792 rs12413268 chr10:71205504 G/A cg12610070 chr10:71211762 TSPAN15 -0.46 -6.7 -0.34 9.11e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11190604 1.000 rs7080356 chr10:102266735 A/C cg07080220 chr10:102295463 HIF1AN 0.68 9.42 0.46 7.59e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1178968 0.901 rs2353066 chr7:72755791 T/G cg25889504 chr7:72793014 NA 0.59 7.96 0.4 2.69e-14 Triglyceride levels; LUSC cis rs2282802 0.685 rs10051345 chr5:139670932 C/G cg26211634 chr5:139558579 C5orf32 -0.39 -7.61 -0.38 2.86e-13 Intelligence (multi-trait analysis); LUSC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg12658694 chr1:38397304 INPP5B -0.42 -5.81 -0.3 1.48e-8 Coronary artery disease; LUSC cis rs7903847 0.642 rs11189196 chr10:99155079 A/G cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs1949733 0.523 rs4619877 chr4:8543235 G/A cg11789530 chr4:8429930 ACOX3 -0.41 -6.01 -0.31 4.89e-9 Response to antineoplastic agents; LUSC cis rs9361491 0.508 rs9343786 chr6:79414728 A/C cg05283184 chr6:79620031 NA 0.38 6.77 0.35 5.78e-11 Intelligence (multi-trait analysis); LUSC cis rs765787 0.530 rs1648289 chr15:45516494 A/G cg25801113 chr15:45476975 SHF 0.33 6.83 0.35 4.06e-11 Uric acid levels; LUSC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg02753203 chr1:228287806 NA 0.7 12.45 0.56 1.71e-29 Diastolic blood pressure; LUSC trans rs2288327 0.643 rs1559908 chr2:179336347 C/T cg14011486 chr1:26737247 LIN28 -0.84 -11.8 -0.54 4.43e-27 Atrial fibrillation; LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs7084921 0.552 rs11598495 chr10:101889417 T/C cg02250046 chr10:101825185 CPN1 -0.33 -6.06 -0.31 3.58e-9 Bone mineral density; LUSC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg00944433 chr1:107599041 PRMT6 -0.38 -7.22 -0.37 3.51e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11644478 chr21:40555479 PSMG1 0.93 17.85 0.7 1.62e-50 Cognitive function; LUSC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg06238570 chr21:40685208 BRWD1 -0.52 -8.02 -0.4 1.82e-14 Cognitive function; LUSC cis rs5769707 0.706 rs2071903 chr22:50034517 G/A cg20744362 chr22:50050164 C22orf34 0.39 7.42 0.38 9.81e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs75804782 0.521 rs72994973 chr2:239428315 C/T cg18131467 chr2:239335373 ASB1 -0.67 -6.01 -0.31 4.73e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg15445000 chr17:37608096 MED1 -0.4 -6.79 -0.35 5.25e-11 Glomerular filtration rate (creatinine); LUSC cis rs2762353 0.935 rs1165152 chr6:25818766 A/G cg03264133 chr6:25882463 NA -0.44 -7.74 -0.39 1.16e-13 Blood metabolite levels; LUSC cis rs11676348 0.904 rs10804264 chr2:218955809 T/C cg00012203 chr2:219082015 ARPC2 -0.54 -8.33 -0.41 2.15e-15 Ulcerative colitis; LUSC trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg15704280 chr7:45808275 SEPT13 0.73 8.39 0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg13685833 chr1:53393034 SCP2 -0.39 -5.86 -0.31 1.11e-8 Monocyte count; LUSC cis rs6693567 0.545 rs7553647 chr1:150472666 C/T cg15654264 chr1:150340011 RPRD2 0.45 7.21 0.37 3.83e-12 Migraine; LUSC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs950169 0.922 rs17531523 chr15:85132449 C/G cg12863693 chr15:85201151 NMB 0.37 7.44 0.38 8.69e-13 Schizophrenia; LUSC cis rs3857536 0.740 rs7766407 chr6:66885658 C/A cg07460842 chr6:66804631 NA -0.46 -6.47 -0.33 3.5e-10 Blood trace element (Cu levels); LUSC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg09455208 chr3:40491958 NA 0.57 9.87 0.48 2.42e-20 Renal cell carcinoma; LUSC cis rs10740039 0.883 rs1442545 chr10:62410026 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.85 -0.35 3.61e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7617773 0.780 rs34946886 chr3:48338487 A/G cg11946769 chr3:48343235 NME6 0.88 14.29 0.62 1.69e-36 Coronary artery disease; LUSC trans rs10435719 0.647 rs10092605 chr8:11787395 T/G cg14343924 chr8:8086146 FLJ10661 0.44 6.22 0.32 1.48e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs12995849 0.905 rs6712210 chr2:106449251 G/A cg14210321 chr2:106509881 NCK2 -0.4 -5.96 -0.31 6.39e-9 Addiction; LUSC cis rs478222 0.866 rs11684464 chr2:25340610 A/G cg01884057 chr2:25150051 NA -0.26 -5.73 -0.3 2.29e-8 Type 1 diabetes; LUSC cis rs1372520 0.935 rs1372519 chr4:90757309 A/G cg01966878 chr4:90757139 SNCA -0.43 -6.16 -0.32 2.05e-9 Neuroticism; LUSC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg06453172 chr10:134556979 INPP5A -0.47 -5.84 -0.3 1.26e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Drug-induced liver injury (flucloxacillin); LUSC trans rs35110281 0.782 rs6518309 chr21:45047992 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 10.8 0.51 1.6e-23 Mean corpuscular volume; LUSC cis rs12291225 0.679 rs11238 chr11:14288128 A/C cg19336497 chr11:14380999 RRAS2 0.57 11.68 0.54 1.17e-26 Sense of smell; LUSC cis rs2688608 1.000 rs2688608 chr10:75658349 G/T cg23231163 chr10:75533350 FUT11 -0.38 -6.29 -0.33 9.72e-10 Inflammatory bowel disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg06875318 chr12:122064821 ORAI1 -0.45 -5.96 -0.31 6.35e-9 Hepatitis; LUSC cis rs1256061 0.603 rs10148269 chr14:64736924 A/G cg23250157 chr14:64679961 SYNE2 0.32 5.71 0.3 2.56e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs2219968 0.962 rs4380933 chr8:78944192 A/G cg00738934 chr8:78996279 NA 0.38 6.81 0.35 4.41e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.01 0.52 2.98e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg22834771 chr12:69754056 YEATS4 -0.48 -7.33 -0.37 1.7e-12 Blood protein levels; LUSC cis rs652260 0.967 rs667295 chr19:7901634 G/A cg26014689 chr19:7917955 EVI5L -0.48 -8.35 -0.42 1.83e-15 Menarche (age at onset); LUSC cis rs17376456 0.569 rs7702348 chr5:93065683 A/G cg25358565 chr5:93447407 FAM172A -0.54 -7.78 -0.39 9.36e-14 Diabetic retinopathy; LUSC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg11301795 chr4:187892539 NA -0.85 -16.73 -0.68 4.42e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.904 rs6060197 chr20:33654315 C/T cg07148914 chr20:33460835 GGT7 -0.46 -6.74 -0.35 7.17e-11 Height; LUSC cis rs7793919 0.726 rs10261971 chr7:4776547 A/G cg00064840 chr7:4784485 FOXK1 0.3 5.72 0.3 2.38e-8 Mosquito bite size; LUSC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC cis rs4285028 0.731 rs2332035 chr3:121715432 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.55 -7.17 -0.37 4.75e-12 Multiple sclerosis; LUSC cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg23711669 chr6:146136114 FBXO30 0.8 13.96 0.61 3.3e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.545 rs11043 chr16:68262958 G/A cg09835421 chr16:68378352 PRMT7 -0.57 -6.19 -0.32 1.77e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7712401 0.580 rs439739 chr5:122318421 G/C cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg20135002 chr11:47629003 NA -0.48 -7.64 -0.39 2.34e-13 Subjective well-being; LUSC trans rs1015291 0.708 rs941232 chr12:19993733 G/C cg01501474 chr7:55323552 NA 0.46 6.03 0.31 4.36e-9 Diastolic blood pressure; LUSC trans rs6598955 0.671 rs59143843 chr1:26641595 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.03 -0.4 1.66e-14 Obesity-related traits; LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC cis rs10911363 0.570 rs2702204 chr1:183457396 A/G cg09173681 chr1:183549694 NCF2 0.64 11.43 0.53 9.04e-26 Systemic lupus erythematosus; LUSC cis rs7927592 0.871 rs113020558 chr11:68296832 G/A cg20283391 chr11:68216788 NA -0.62 -8.62 -0.43 2.7e-16 Total body bone mineral density; LUSC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg10802521 chr3:52805072 NEK4 -0.53 -8.57 -0.42 3.93e-16 Bipolar disorder; LUSC cis rs56161922 0.908 rs55689175 chr1:207859699 G/C cg11752769 chr1:207818423 CR1L -0.7 -5.91 -0.31 8.43e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs740160 0.558 rs73395508 chr7:98901894 A/C cg24650262 chr7:98904301 NA 0.61 6.3 0.33 9.42e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs9398803 0.687 rs4629706 chr6:126888331 A/T cg19875578 chr6:126661172 C6orf173 0.39 5.72 0.3 2.36e-8 Male-pattern baldness; LUSC cis rs11785400 1.000 rs7459630 chr8:143738585 A/C cg10596483 chr8:143751796 JRK 0.6 9.21 0.45 3.65e-18 Schizophrenia; LUSC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.36 -0.37 1.48e-12 Bipolar disorder; LUSC cis rs9788721 0.836 rs7181486 chr15:78741618 C/T cg18825076 chr15:78729989 IREB2 0.6 9.91 0.48 1.8e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg06238570 chr21:40685208 BRWD1 -0.53 -8.21 -0.41 4.79e-15 Menarche (age at onset); LUSC cis rs259282 0.538 rs62124303 chr19:33113042 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.68 10.07 0.48 5.3e-21 Schizophrenia; LUSC trans rs10090774 0.664 rs28605671 chr8:141655112 T/G cg02991888 chr19:54260014 MIR1283-2;MIR516A1 0.29 5.95 0.31 6.77e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs11229555 0.645 rs11229462 chr11:58209931 A/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs2386661 0.547 rs72781996 chr10:5646485 C/G cg11398623 chr21:37499189 NA 0.28 6.27 0.32 1.15e-9 Breast cancer; LUSC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg04871131 chr7:94954202 PON1 -0.39 -6.11 -0.32 2.7e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg07395648 chr5:131743802 NA 0.4 5.83 0.3 1.32e-8 Breast cancer; LUSC cis rs7909074 0.798 rs914699 chr10:45377066 A/C cg05187965 chr10:45406764 TMEM72 -0.36 -8.47 -0.42 7.95e-16 Mean corpuscular volume; LUSC cis rs10504229 0.679 rs60869047 chr8:58053221 G/A cg22535103 chr8:58192502 C8orf71 -0.57 -6.54 -0.34 2.29e-10 Developmental language disorder (linguistic errors); LUSC cis rs782590 0.738 rs4312532 chr2:55812061 A/G cg18811423 chr2:55921094 PNPT1 -0.73 -11.4 -0.53 1.2e-25 Metabolic syndrome; LUSC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg15369054 chr17:80825471 TBCD -0.4 -6.52 -0.34 2.53e-10 Breast cancer; LUSC cis rs62400317 0.826 rs12203466 chr6:45330263 T/A cg18551225 chr6:44695536 NA -0.44 -7.32 -0.37 1.92e-12 Total body bone mineral density; LUSC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg01475377 chr6:109611718 NA -0.41 -7.36 -0.37 1.47e-12 Reticulocyte fraction of red cells; LUSC cis rs7267979 0.866 rs6138609 chr20:25570985 T/A cg24626310 chr20:25276739 ABHD12;PYGB 0.82 17.65 0.69 1e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1832871 0.672 rs11751553 chr6:158774750 C/T cg07165851 chr6:158734300 TULP4 -0.48 -7.38 -0.37 1.31e-12 Height; LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg16405210 chr4:1374714 KIAA1530 0.55 8.28 0.41 2.95e-15 Obesity-related traits; LUSC cis rs2063714 0.967 rs1012534 chr6:157209663 A/G cg23222435 chr6:157204239 ARID1B -0.56 -9.3 -0.45 1.87e-18 Sitting height ratio; LUSC trans rs853679 0.607 rs33932084 chr6:28268824 A/G cg06606381 chr12:133084897 FBRSL1 -0.9 -8.8 -0.43 7.6e-17 Depression; LUSC cis rs11155671 0.530 rs2342767 chr6:150209717 C/G cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC cis rs1614887 1 rs1614887 chr6:26393021 A/G cg05738196 chr6:26577821 NA 0.54 7.95 0.4 2.87e-14 Intelligence (multi-trait analysis);Lobe attachment (rater-scored or self-reported); LUSC cis rs3126085 0.935 rs4845423 chr1:152184950 T/G cg03465714 chr1:152285911 FLG -0.4 -5.71 -0.3 2.53e-8 Atopic dermatitis; LUSC cis rs7561273 0.586 rs11892283 chr2:24317850 T/C cg06627628 chr2:24431161 ITSN2 -0.52 -6.84 -0.35 3.89e-11 Quantitative traits; LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg07507251 chr3:52567010 NT5DC2 0.32 6.25 0.32 1.28e-9 Bipolar disorder; LUSC cis rs4268898 0.697 rs6714652 chr2:24383059 C/T cg06627628 chr2:24431161 ITSN2 0.53 7.41 0.38 1.07e-12 Asthma; LUSC trans rs9944715 1.000 rs9952654 chr18:43849568 T/G cg01718231 chr17:29326311 RNF135 -0.51 -7.16 -0.36 5.04e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.64 -8.27 -0.41 3.23e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8062405 0.755 rs4787455 chr16:28589455 G/A cg07382826 chr16:28625726 SULT1A1 0.28 5.97 0.31 6.13e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10791323 0.521 rs10894756 chr11:133745852 G/A cg15485101 chr11:133734466 NA 0.35 6.3 0.33 9.3e-10 Childhood ear infection; LUSC cis rs7208859 0.623 rs122898 chr17:28905254 C/T cg13385521 chr17:29058706 SUZ12P -0.64 -6.49 -0.33 3.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26543917 chr17:1420092 INPP5K;LOC100306951 -0.41 -6.07 -0.32 3.51e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4820539 0.966 rs5996470 chr22:23483255 G/A cg14186256 chr22:23484241 RTDR1 0.98 18.87 0.72 1.43e-54 Bone mineral density; LUSC trans rs17685 0.736 rs4732594 chr7:75753273 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2230307 0.536 rs7530361 chr1:100462860 T/C cg24955406 chr1:100503596 HIAT1 0.56 6.08 0.32 3.31e-9 Carotid intima media thickness; LUSC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg14298792 chr15:30685198 CHRFAM7A 0.48 6.06 0.31 3.65e-9 Huntington's disease progression; LUSC cis rs7927592 0.913 rs67947146 chr11:68314980 C/T cg01657329 chr11:68192670 LRP5 -0.39 -5.67 -0.3 3.17e-8 Total body bone mineral density; LUSC cis rs4631830 0.828 rs10763567 chr10:51538169 C/A cg10326726 chr10:51549505 MSMB 0.34 5.65 0.3 3.42e-8 Prostate-specific antigen levels; LUSC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg12963246 chr6:28129442 ZNF389 0.55 7.63 0.39 2.55e-13 Depression; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18217145 chr1:40254695 BMP8B 0.74 5.98 0.31 5.84e-9 Cognitive performance; LUSC cis rs6121246 0.559 rs6060962 chr20:30397847 A/G cg13852791 chr20:30311386 BCL2L1 0.94 14.61 0.62 1.01e-37 Mean corpuscular hemoglobin; LUSC trans rs2587949 0.615 rs2629242 chr3:4225060 T/C cg15139668 chr4:4577005 NA -0.41 -6.07 -0.32 3.51e-9 Periodontitis (DPAL); LUSC trans rs7937682 0.889 rs1789359 chr11:111475995 T/A cg18187862 chr3:45730750 SACM1L 0.52 6.83 0.35 4e-11 Primary sclerosing cholangitis; LUSC cis rs7904368 0.659 rs3740169 chr10:16873547 C/T cg14835575 chr10:16859367 RSU1 0.65 9.16 0.45 5.54e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC trans rs10432489 0.708 rs4436925 chr2:181755933 T/C cg09897338 chr1:211849090 NEK2 -0.82 -6.07 -0.32 3.4e-9 QT interval; LUSC cis rs7666738 0.546 rs1863602 chr4:98909304 T/C cg03676636 chr4:99064102 C4orf37 0.3 6.1 0.32 2.99e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9650315 0.866 rs13270548 chr8:57196239 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.56 -7.18 -0.37 4.46e-12 Height; LUSC cis rs9905704 0.918 rs390524 chr17:56674173 A/G cg12560992 chr17:57184187 TRIM37 0.55 7.7 0.39 1.56e-13 Testicular germ cell tumor; LUSC cis rs9831754 0.704 rs7647185 chr3:78468807 T/C cg06138941 chr3:78371609 NA -0.52 -6.93 -0.35 2.21e-11 Calcium levels; LUSC cis rs13089785 1.000 rs2271969 chr3:123650432 A/G cg02012769 chr3:123398346 MYLK 0.34 6.25 0.32 1.26e-9 Intelligence (multi-trait analysis); LUSC trans rs2235573 0.551 rs139897 chr22:38399098 A/G cg19894588 chr14:64061835 NA 0.49 7.04 0.36 1.1e-11 Glioblastoma;Glioma; LUSC trans rs17597773 0.638 rs12139139 chr1:221000626 G/A cg25786136 chr2:222575520 NA 0.39 5.94 0.31 6.99e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs472402 0.560 rs2303705 chr5:6622017 A/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.43 -6.42 -0.33 4.79e-10 Response to amphetamines; LUSC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs2758596 0.850 rs2241110 chr1:156172487 A/G cg25208724 chr1:156163844 SLC25A44 0.79 6.57 0.34 1.94e-10 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg05985134 chr18:33552581 C18orf21 0.52 7.12 0.36 6.56e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg13256891 chr4:100009986 ADH5 -0.45 -6.18 -0.32 1.85e-9 Alcohol dependence; LUSC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg05872129 chr22:39784769 NA -0.61 -11.68 -0.54 1.19e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs1982963 0.901 rs1566131 chr14:52514684 G/A cg10843707 chr14:52510701 NID2 -0.39 -6.7 -0.34 8.81e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.56 8.42 0.42 1.1e-15 Total body bone mineral density; LUSC cis rs9303542 0.625 rs7207109 chr17:46607817 C/T cg09704116 chr17:46666958 LOC404266 -0.37 -6.79 -0.35 5.27e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6484504 0.625 rs1535741 chr11:31375072 T/C cg06552810 chr11:31128660 NA 0.39 6.78 0.35 5.49e-11 Red blood cell count; LUSC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg00825309 chr19:58991885 ZNF446 -0.49 -7.03 -0.36 1.18e-11 Uric acid clearance; LUSC trans rs1908814 0.516 rs60176945 chr8:11796674 T/C cg27411982 chr8:10470053 RP1L1 0.4 6.18 0.32 1.91e-9 Neuroticism; LUSC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg08704250 chr15:31115839 NA 0.44 5.8 0.3 1.55e-8 Huntington's disease progression; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg22903657 chr4:1355424 KIAA1530 -0.37 -6.15 -0.32 2.19e-9 Obesity-related traits; LUSC cis rs4132509 0.793 rs34477525 chr1:243966454 T/A cg21452805 chr1:244014465 NA 0.49 5.7 0.3 2.58e-8 RR interval (heart rate); LUSC cis rs1728785 0.818 rs11648503 chr16:68598938 G/A cg02972257 chr16:68554789 NA -0.52 -6.48 -0.33 3.26e-10 Ulcerative colitis; LUSC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg23711669 chr6:146136114 FBXO30 -0.92 -17.61 -0.69 1.45e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg05855489 chr10:104503620 C10orf26 0.54 7.91 0.4 3.91e-14 Arsenic metabolism; LUSC cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg02782426 chr3:40428986 ENTPD3 0.3 5.76 0.3 1.93e-8 Renal cell carcinoma; LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg11062466 chr8:58055876 NA 0.74 7.13 0.36 6.08e-12 Developmental language disorder (linguistic errors); LUSC cis rs9486719 0.947 rs2472893 chr6:96870048 G/C cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs950169 0.922 rs6603022 chr15:84830170 T/C cg17173187 chr15:85201210 NMB -0.37 -6.7 -0.34 8.96e-11 Schizophrenia; LUSC cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg22508957 chr16:3507546 NAT15 0.42 6.08 0.32 3.36e-9 Body mass index (adult); LUSC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.79 0.35 5.18e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1691799 0.899 rs1168307 chr12:66739539 A/G cg16791601 chr12:66731901 HELB -0.72 -12.57 -0.57 5.92e-30 White blood cell count (basophil); LUSC cis rs9796 0.866 rs544744 chr15:41366290 G/C cg18705301 chr15:41695430 NDUFAF1 -0.45 -7.83 -0.39 6.67e-14 Menopause (age at onset); LUSC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg05855489 chr10:104503620 C10orf26 -0.64 -8.61 -0.43 2.84e-16 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.93 0.4 3.25e-14 Hemoglobin concentration; LUSC cis rs2651899 0.902 rs1736522 chr1:3080940 C/G cg22674798 chr1:3096360 PRDM16 0.33 7.72 0.39 1.36e-13 Migraine; LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg03354898 chr7:1950403 MAD1L1 -0.34 -6.61 -0.34 1.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs9616064 0.886 rs11703960 chr22:46986423 A/T cg05621596 chr22:47072043 GRAMD4 -0.44 -6.26 -0.32 1.18e-9 Urate levels in obese individuals; LUSC trans rs11165623 0.765 rs12749081 chr1:96970371 A/C cg10631902 chr5:14652156 NA -0.44 -6.77 -0.35 5.69e-11 Hip circumference;Waist circumference; LUSC cis rs10493773 0.609 rs6689168 chr1:86174232 G/T cg17807903 chr1:86174739 ZNHIT6 -0.54 -14.75 -0.63 2.97e-38 Urate levels in overweight individuals; LUSC cis rs9300255 0.544 rs1790130 chr12:123701270 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg04025307 chr7:1156635 C7orf50 0.54 8.46 0.42 8.32e-16 Longevity;Endometriosis; LUSC cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg08807101 chr21:30365312 RNF160 -0.72 -12.75 -0.57 1.27e-30 Dental caries; LUSC cis rs9303401 0.659 rs17222523 chr17:56620501 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.34 0.59 8.12e-33 Cognitive test performance; LUSC cis rs4478858 0.602 rs6425723 chr1:31715204 T/C cg00250761 chr1:31883323 NA -0.34 -8.35 -0.42 1.86e-15 Alcohol dependence; LUSC cis rs3540 0.597 rs4932346 chr15:91048991 T/C cg10434728 chr15:90938212 IQGAP1 -0.44 -8.94 -0.44 2.8e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg15369054 chr17:80825471 TBCD 0.49 7.98 0.4 2.44e-14 Breast cancer; LUSC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg21770322 chr7:97807741 LMTK2 0.4 6.99 0.36 1.47e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1256061 0.603 rs1256036 chr14:64743332 C/T cg23250157 chr14:64679961 SYNE2 0.32 5.71 0.3 2.56e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg17815252 chr3:142838682 CHST2 0.47 6.02 0.31 4.54e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg04398451 chr17:18023971 MYO15A -0.5 -7.98 -0.4 2.39e-14 Total body bone mineral density; LUSC cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg12615879 chr12:58013172 SLC26A10 -0.31 -6.45 -0.33 3.99e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg01879757 chr17:41196368 BRCA1 -0.48 -7.77 -0.39 1.01e-13 Menopause (age at onset); LUSC cis rs1865760 0.566 rs3752419 chr6:26027433 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.76 0.35 6.05e-11 Height; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg03790207 chr6:42947109 PEX6 -0.45 -6.9 -0.35 2.55e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.58 8.24 0.41 4.06e-15 Alzheimer's disease; LUSC cis rs2486288 0.656 rs12915314 chr15:45551491 C/G cg09092052 chr15:45571596 NA 0.45 6.26 0.32 1.18e-9 Glomerular filtration rate; LUSC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg21963583 chr11:68658836 MRPL21 0.56 8.56 0.42 4.26e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg16339924 chr4:17578868 LAP3 0.55 8.51 0.42 5.79e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs459482 1.000 rs459498 chr21:42795027 G/A cg21549285 chr21:42799141 MX1 0.38 5.87 0.31 1.08e-8 IgG glycosylation; LUSC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 9.86 0.47 2.73e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg03146154 chr1:46216737 IPP 0.56 8.39 0.42 1.39e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7824557 0.564 rs7839307 chr8:11198792 A/G cg15556689 chr8:8085844 FLJ10661 0.52 7.63 0.39 2.46e-13 Retinal vascular caliber; LUSC cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -7.67 -0.39 1.9e-13 Schizophrenia; LUSC cis rs8062405 1.000 rs28403629 chr16:28854769 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs12310956 0.510 rs4931759 chr12:33871969 T/C cg26384229 chr12:38710491 ALG10B 0.54 8.4 0.42 1.3e-15 Morning vs. evening chronotype; LUSC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg21724239 chr8:58056113 NA 0.67 7.46 0.38 7.68e-13 Developmental language disorder (linguistic errors); LUSC cis rs9467773 1.000 rs6924838 chr6:26571756 C/T cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.47e-42 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 10.06 0.48 5.59e-21 Bipolar disorder; LUSC cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs1670533 1.000 rs6812596 chr4:1069866 A/G cg27284194 chr4:1044797 NA 0.58 8.9 0.44 3.65e-17 Recombination rate (females); LUSC cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -7.01 -0.36 1.31e-11 Monocyte percentage of white cells; LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg00166722 chr3:10149974 C3orf24 0.54 7.42 0.38 9.76e-13 Alzheimer's disease; LUSC cis rs6964587 0.692 rs2299233 chr7:91626953 C/T cg17063962 chr7:91808500 NA -0.57 -9.56 -0.46 2.63e-19 Breast cancer; LUSC trans rs61931739 0.929 rs1490110 chr12:34091605 A/G cg26384229 chr12:38710491 ALG10B -0.58 -9.28 -0.45 2.25e-18 Morning vs. evening chronotype; LUSC cis rs9325144 0.505 rs7138977 chr12:38642109 G/A cg13010199 chr12:38710504 ALG10B 0.58 8.88 0.44 4.16e-17 Morning vs. evening chronotype; LUSC cis rs7681440 0.874 rs10028246 chr4:90766704 G/A cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC trans rs2243480 1.000 rs1546059 chr7:65654709 C/A cg10756647 chr7:56101905 PSPH -0.87 -8.68 -0.43 1.74e-16 Diabetic kidney disease; LUSC trans rs877282 0.898 rs12354872 chr10:763362 G/A cg22713356 chr15:30763199 NA 1.05 13.89 0.61 5.97e-35 Uric acid levels; LUSC cis rs73206853 0.688 rs55805203 chr12:110819142 G/T cg12870014 chr12:110450643 ANKRD13A 0.67 6.31 0.33 8.63e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs3125734 0.633 rs4979773 chr10:63967731 G/C cg09941381 chr10:64027924 RTKN2 -0.39 -7.41 -0.38 1.06e-12 Rheumatoid arthritis; LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.78 0.47 5.05e-20 Bipolar disorder; LUSC trans rs12210905 1.000 rs72838266 chr6:27015052 T/C cg11837749 chr1:55047332 ACOT11 0.58 6.07 0.32 3.47e-9 Hip circumference adjusted for BMI; LUSC cis rs7923452 1.000 rs7923452 chr10:30751171 T/C cg18806716 chr10:30721971 MAP3K8 0.61 7.4 0.38 1.1e-12 Itch intensity from mosquito bite; LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg08088566 chr11:430123 ANO9 0.64 7.14 0.36 5.91e-12 Body mass index; LUSC cis rs9300255 0.550 rs10772997 chr12:123719880 C/A cg05973401 chr12:123451056 ABCB9 0.51 7.06 0.36 9.93e-12 Neutrophil percentage of white cells; LUSC cis rs748404 0.723 rs512431 chr15:43541939 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.41 -5.94 -0.31 7.03e-9 Lung cancer; LUSC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg13393036 chr8:95962371 TP53INP1 -0.32 -6.22 -0.32 1.51e-9 Type 2 diabetes; LUSC trans rs911555 0.755 rs1116095 chr14:103931879 A/G cg17675199 chr6:35436792 RPL10A -0.43 -6.31 -0.33 8.84e-10 Intelligence (multi-trait analysis); LUSC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg04546413 chr19:29218101 NA 0.71 11.0 0.52 3.19e-24 Methadone dose in opioid dependence; LUSC trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg15704280 chr7:45808275 SEPT13 0.73 8.22 0.41 4.64e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs7712401 0.791 rs6887101 chr5:122109207 C/T cg19077854 chr5:122220652 SNX24 -0.35 -7.83 -0.39 6.52e-14 Mean platelet volume; LUSC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -6.56 -0.34 2.03e-10 Developmental language disorder (linguistic errors); LUSC cis rs11924390 0.789 rs822366 chr3:186452490 A/G cg12454167 chr3:186435060 KNG1 0.29 7.49 0.38 6.34e-13 Adiponectin levels; LUSC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg05855489 chr10:104503620 C10orf26 0.58 9.25 0.45 2.69e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs2727020 0.658 rs4980440 chr11:49386017 C/T cg03929089 chr4:120376271 NA -0.97 -16.51 -0.67 3.48e-45 Coronary artery disease; LUSC cis rs950776 0.593 rs588765 chr15:78865425 T/C cg22563815 chr15:78856949 CHRNA5 -0.25 -6.2 -0.32 1.65e-9 Sudden cardiac arrest; LUSC trans rs7613875 0.620 rs2526747 chr3:50082914 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.53 8.66 0.43 2.01e-16 Body mass index; LUSC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.85 -0.35 3.58e-11 Intelligence (multi-trait analysis); LUSC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg11764359 chr7:65958608 NA -0.7 -10.63 -0.5 6.55e-23 Aortic root size; LUSC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg23985595 chr17:80112537 CCDC57 0.31 5.95 0.31 6.67e-9 Life satisfaction; LUSC cis rs701145 0.556 rs355751 chr3:153971602 T/C cg17054900 chr3:154042577 DHX36 0.44 5.77 0.3 1.77e-8 Coronary artery disease; LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg02475777 chr4:1388615 CRIPAK 0.41 6.13 0.32 2.46e-9 Obesity-related traits; LUSC cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg23711669 chr6:146136114 FBXO30 0.75 13.26 0.59 1.61e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs17826219 0.706 rs55764512 chr17:29085758 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Body mass index; LUSC cis rs4474465 0.915 rs10128737 chr11:78186687 G/A cg27205649 chr11:78285834 NARS2 -0.48 -5.67 -0.3 3.03e-8 Alzheimer's disease (survival time); LUSC cis rs113835537 0.935 rs117480267 chr11:66398596 C/T cg24851651 chr11:66362959 CCS 0.55 6.81 0.35 4.42e-11 Airway imaging phenotypes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21395152 chr1:212780243 ATF3 -0.44 -6.69 -0.34 9.65e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1215050 0.791 rs1648546 chr4:98899294 T/C cg05340658 chr4:99064831 C4orf37 -0.44 -6.96 -0.36 1.85e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg03433033 chr1:76189801 ACADM -0.81 -13.1 -0.58 6.17e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7954584 0.546 rs10840630 chr12:122352445 C/T cg21016266 chr12:122356598 WDR66 0.62 9.05 0.44 1.22e-17 Mean corpuscular volume; LUSC cis rs68170813 0.599 rs11769901 chr7:106958505 G/A cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC cis rs6066835 1.000 rs6095270 chr20:47356062 T/C cg18078177 chr20:47281410 PREX1 0.75 6.44 0.33 4.08e-10 Multiple myeloma; LUSC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg18876405 chr7:65276391 NA -0.54 -8.52 -0.42 5.73e-16 Aortic root size; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg09021430 chr5:549028 NA -0.56 -8.68 -0.43 1.75e-16 Obesity-related traits; LUSC cis rs500891 0.553 rs13215909 chr6:84130396 C/G cg08257003 chr6:84140564 ME1 0.37 9.11 0.45 7.86e-18 Platelet-derived growth factor BB levels; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg21782813 chr7:2030301 MAD1L1 0.41 6.82 0.35 4.34e-11 Bipolar disorder and schizophrenia; LUSC cis rs2637266 0.846 rs2583045 chr10:78412385 C/G cg18941641 chr10:78392320 NA -0.37 -6.68 -0.34 9.86e-11 Pulmonary function; LUSC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg14416269 chr4:6271139 WFS1 0.54 11.41 0.53 1.08e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7589342 0.929 rs12053259 chr2:106428720 G/A cg16077055 chr2:106428750 NCK2 0.38 7.29 0.37 2.22e-12 Addiction; LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs3820928 1.000 rs6723774 chr2:227770592 C/T cg11843606 chr2:227700838 RHBDD1 0.52 7.68 0.39 1.78e-13 Pulmonary function; LUSC cis rs4293296 0.525 rs28619304 chr14:54823270 A/G cg02257953 chr14:54816093 NA -0.44 -6.19 -0.32 1.78e-9 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs12681287 0.547 rs13249177 chr8:87513034 A/G cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg27446573 chr6:127587934 RNF146 0.92 15.3 0.64 2.12e-40 Breast cancer; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg23978390 chr7:1156363 C7orf50 0.52 7.4 0.38 1.09e-12 Longevity;Endometriosis; LUSC cis rs2976388 1.000 rs2920296 chr8:143763109 A/G cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs10979 0.669 rs9484764 chr6:143867336 G/T cg25407410 chr6:143891975 LOC285740 -0.54 -7.34 -0.37 1.63e-12 Hypospadias; LUSC cis rs713477 0.678 rs4901566 chr14:55912663 C/A cg13175173 chr14:55914753 NA -0.3 -6.24 -0.32 1.34e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs763121 0.853 rs5757162 chr22:38993370 C/T cg06022373 chr22:39101656 GTPBP1 0.76 11.86 0.54 2.65e-27 Menopause (age at onset); LUSC cis rs4845459 0.967 rs75567512 chr1:152587933 C/A cg08895932 chr1:152778580 LCE1C -0.36 -6.31 -0.33 9.09e-10 Psoriasis; LUSC cis rs9660992 0.700 rs7547565 chr1:205259402 G/A cg21643547 chr1:205240462 TMCC2 0.48 9.28 0.45 2.26e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs425277 1.000 rs385039 chr1:2077409 C/T cg24578937 chr1:2090814 PRKCZ -0.6 -13.72 -0.6 2.77e-34 Height; LUSC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.76 0.39 1.01e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs61931739 0.534 rs11053072 chr12:34202399 A/C cg13010199 chr12:38710504 ALG10B 0.56 8.62 0.43 2.75e-16 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg08219700 chr8:58056026 NA 0.49 6.1 0.32 3.01e-9 Developmental language disorder (linguistic errors); LUSC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg20090143 chr19:45452003 APOC2 0.47 9.14 0.45 6.27e-18 Blood protein levels; LUSC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs3820068 0.608 rs9660255 chr1:16031891 T/G cg24675056 chr1:15929824 NA 0.4 6.58 0.34 1.87e-10 Systolic blood pressure; LUSC cis rs9341808 0.718 rs9352806 chr6:80980057 G/T cg08355045 chr6:80787529 NA 0.55 9.71 0.47 8.33e-20 Sitting height ratio; LUSC cis rs6840360 1.000 rs4696283 chr4:152580516 A/G cg22705602 chr4:152727874 NA -0.28 -5.84 -0.3 1.26e-8 Intelligence (multi-trait analysis); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11730100 chr11:61560294 FEN1;C11orf10;MIR611 -0.48 -6.44 -0.33 4.09e-10 Hepatitis; LUSC cis rs9359856 0.636 rs4706345 chr6:90301565 C/T cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.87 -0.4 5.13e-14 Bipolar disorder; LUSC cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg00083206 chr6:110721305 DDO -0.45 -8.28 -0.41 2.95e-15 Platelet distribution width; LUSC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg06484146 chr7:12443880 VWDE -0.74 -7.61 -0.38 2.77e-13 Coronary artery disease; LUSC cis rs868036 0.561 rs28376697 chr15:68140315 A/G cg08079166 chr15:68083412 MAP2K5 0.43 6.66 0.34 1.14e-10 Restless legs syndrome; LUSC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC trans rs2204008 0.639 rs7311462 chr12:38278130 G/A cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC cis rs11971779 0.616 rs2883772 chr7:139072756 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1775715 0.870 rs1615256 chr10:32254101 T/C cg03015672 chr10:32216066 ARHGAP12 0.33 5.69 0.3 2.85e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1035144 0.505 rs10145099 chr14:81456694 C/T cg06600135 chr14:81408086 NA -0.59 -8.51 -0.42 5.84e-16 Male sexual orientation; LUSC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg24154853 chr7:158122151 PTPRN2 0.41 8.16 0.41 7.08e-15 Calcium levels; LUSC cis rs7712401 0.525 rs246312 chr5:122269455 G/A cg19077854 chr5:122220652 SNX24 0.41 8.94 0.44 2.64e-17 Mean platelet volume; LUSC cis rs7178572 0.598 rs907373 chr15:77844554 T/C cg22256960 chr15:77711686 NA -0.41 -6.62 -0.34 1.46e-10 Type 2 diabetes; LUSC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg00343986 chr7:65444356 GUSB 0.45 6.92 0.35 2.33e-11 Aortic root size; LUSC cis rs9653442 0.545 rs13032454 chr2:100756009 T/C cg07810366 chr2:100720526 AFF3 -0.45 -7.63 -0.39 2.54e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7760535 0.811 rs7764591 chr6:111783414 G/C cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.46 -0.33 3.79e-10 Metabolic traits; LUSC cis rs2276314 1.000 rs16967317 chr18:33573400 A/G cg19628046 chr18:33552617 C18orf21 0.49 5.87 0.31 1.05e-8 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7909074 1.000 rs7909074 chr10:45395839 G/A cg05187965 chr10:45406764 TMEM72 -0.38 -8.87 -0.44 4.6e-17 Mean corpuscular volume; LUSC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg20607287 chr7:12443886 VWDE -0.65 -6.59 -0.34 1.74e-10 Coronary artery disease; LUSC cis rs9948 0.786 rs62156226 chr2:97417108 G/A cg01990225 chr2:97406019 LMAN2L -0.78 -5.86 -0.31 1.1e-8 Erectile dysfunction and prostate cancer treatment; LUSC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg18850127 chr7:39170497 POU6F2 0.65 10.57 0.5 9.82e-23 IgG glycosylation; LUSC cis rs7715806 0.509 rs34349 chr5:74944868 A/G cg19683494 chr5:74908142 NA -0.59 -7.29 -0.37 2.24e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9581857 0.585 rs9581875 chr13:28099678 A/G cg22138327 chr13:27999177 GTF3A 0.69 6.98 0.36 1.6e-11 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs11098499 0.818 rs55825515 chr4:120486402 A/G cg24375607 chr4:120327624 NA 0.77 11.22 0.52 5.04e-25 Corneal astigmatism; LUSC cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg00071950 chr4:10020882 SLC2A9 0.53 9.12 0.45 7.46e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs2898290 0.622 rs7822109 chr8:11349147 T/C cg06636001 chr8:8085503 FLJ10661 -0.53 -8.2 -0.41 5.15e-15 Systolic blood pressure; LUSC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg24562669 chr7:97807699 LMTK2 0.35 6.17 0.32 1.98e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3733606 0.503 rs11734132 chr4:6891519 C/G cg05012661 chr4:6891264 NA -0.53 -7.82 -0.39 7.16e-14 Platelet count; LUSC cis rs877282 0.945 rs35342920 chr10:790484 T/C cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg14092988 chr3:52407081 DNAH1 0.32 6.34 0.33 7.42e-10 Bipolar disorder; LUSC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg13918804 chr1:2043761 PRKCZ 0.28 6.01 0.31 4.82e-9 Height; LUSC cis rs12530845 1.000 rs6979391 chr7:135328873 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs11758351 1.000 rs3757135 chr6:26200707 G/A cg01420254 chr6:26195488 NA 0.72 7.48 0.38 6.52e-13 Gout;Renal underexcretion gout; LUSC cis rs9612 0.950 rs11351 chr19:44271066 A/C cg08581076 chr19:44259116 C19orf61 0.46 5.66 0.3 3.3e-8 Exhaled nitric oxide output; LUSC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg18876405 chr7:65276391 NA -0.75 -13.39 -0.59 5.02e-33 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02084811 chr12:49524778 TUBA1B -0.52 -6.32 -0.33 8.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs5769707 0.681 rs4622843 chr22:50036916 T/G cg10356904 chr22:49881777 NA -0.29 -6.14 -0.32 2.41e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12711979 0.904 rs12329356 chr2:3868533 G/C cg17052675 chr2:3827356 NA -0.44 -7.9 -0.4 4.04e-14 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs12519773 0.526 rs4869191 chr5:92525434 A/T cg18783429 chr5:92414398 NA -0.36 -7.38 -0.37 1.24e-12 Migraine; LUSC cis rs9517320 1.000 rs9584856 chr13:99126551 G/T cg07423050 chr13:99094983 FARP1 0.35 6.69 0.34 9.29e-11 Longevity; LUSC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.14 16.33 0.67 1.78e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7264396 0.790 rs4519606 chr20:34324648 T/C cg03168614 chr20:34253242 RBM12;CPNE1 -0.31 -5.68 -0.3 2.9e-8 Total cholesterol levels; LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs2425143 0.512 rs2425126 chr20:34331730 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.23 -0.41 4.21e-15 Blood protein levels; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.38 6.33 0.33 7.97e-10 Electroencephalogram traits; LUSC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg17264618 chr3:40429014 ENTPD3 0.34 7.26 0.37 2.82e-12 Renal cell carcinoma; LUSC cis rs2073300 1.000 rs79255223 chr20:23443559 G/T cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs34779708 0.931 rs10508815 chr10:35332621 A/C cg03585969 chr10:35415529 CREM 0.62 9.1 0.45 8.18e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg13531842 chr10:38383804 ZNF37A -0.45 -7.02 -0.36 1.27e-11 Extrinsic epigenetic age acceleration; LUSC cis rs950027 0.584 rs1145086 chr15:45654327 A/G cg04036182 chr15:45458818 NA 0.35 5.75 0.3 2.01e-8 Response to fenofibrate (adiponectin levels); LUSC trans rs2262909 0.962 rs73019844 chr19:22249925 T/C cg17074339 chr11:11642133 GALNTL4 0.47 7.17 0.37 4.94e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs7944735 0.507 rs7114598 chr11:48101766 C/T cg15704280 chr7:45808275 SEPT13 0.58 7.26 0.37 2.69e-12 Intraocular pressure; LUSC trans rs2243480 1.000 rs35432774 chr7:65393019 G/C cg10756647 chr7:56101905 PSPH 0.87 8.52 0.42 5.71e-16 Diabetic kidney disease; LUSC cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs8177253 0.632 rs6782523 chr3:133438917 C/T cg01448562 chr3:133502909 NA -0.52 -7.47 -0.38 6.95e-13 Iron status biomarkers; LUSC cis rs10992471 0.603 rs4743873 chr9:95270781 C/T cg14631576 chr9:95140430 CENPP 0.33 6.15 0.32 2.17e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs240764 0.604 rs705586 chr6:101268046 C/G cg09795085 chr6:101329169 ASCC3 0.44 6.21 0.32 1.58e-9 Neuroticism; LUSC trans rs3960554 0.808 rs3779419 chr7:75695081 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 9.75 0.47 6.12e-20 Eotaxin levels; LUSC cis rs4253772 0.872 rs11704508 chr22:46638540 A/G cg09491104 chr22:46646882 C22orf40 -0.63 -6.52 -0.34 2.57e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9633740 1.000 rs1870137 chr10:82269848 C/G cg01528321 chr10:82214614 TSPAN14 1.08 11.99 0.55 8.7e-28 Post bronchodilator FEV1; LUSC cis rs3738772 1.000 rs3738773 chr1:110048527 C/T cg08367326 chr1:110052010 AMIGO1 -0.41 -5.7 -0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs9303280 0.901 rs921650 chr17:38069076 G/A cg19468946 chr17:37922297 IKZF3 0.39 6.21 0.32 1.6e-9 Self-reported allergy; LUSC cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg13256891 chr4:100009986 ADH5 0.49 6.85 0.35 3.56e-11 Smoking initiation; LUSC trans rs1814175 0.817 rs12287396 chr11:49819798 G/C cg15704280 chr7:45808275 SEPT13 -1.13 -24.37 -0.8 4.1e-76 Height; LUSC cis rs6430585 0.759 rs4954623 chr2:136535876 G/A cg07169764 chr2:136633963 MCM6 -1.12 -16.2 -0.66 5.82e-44 Corneal structure; LUSC cis rs13202913 0.837 rs6906667 chr6:151772569 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.63 5.67 0.3 3.12e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC trans rs1429264 0.791 rs7188531 chr16:84619996 C/T cg24066931 chr19:1568534 MEX3D -0.43 -5.97 -0.31 5.94e-9 Epilepsy and lamotrigine-induced maculopapular eruptions; LUSC cis rs10761482 0.775 rs1459725 chr10:62138608 C/T cg18175470 chr10:62150864 ANK3 -0.56 -8.44 -0.42 9.57e-16 Schizophrenia; LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg22920501 chr2:26401640 FAM59B -0.82 -12.2 -0.56 1.41e-28 Gut microbiome composition (summer); LUSC cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg11266682 chr4:10021025 SLC2A9 0.57 10.64 0.5 5.82e-23 Bone mineral density; LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC trans rs9860340 0.690 rs2048292 chr3:87634271 A/G cg03644585 chr7:884825 UNC84A 0.42 6.09 0.32 3.17e-9 Electroencephalographic traits in alcoholism; LUSC cis rs9398803 0.897 rs9398804 chr6:126703390 T/A cg19875578 chr6:126661172 C6orf173 0.39 5.68 0.3 2.96e-8 Male-pattern baldness; LUSC cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg16339924 chr4:17578868 LAP3 0.63 9.98 0.48 1.06e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg23791538 chr6:167370224 RNASET2 -0.36 -5.67 -0.3 3.05e-8 Crohn's disease; LUSC cis rs2357013 0.699 rs1510107 chr2:53160137 C/G cg07782112 chr2:53107842 NA -0.37 -5.98 -0.31 5.76e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg03806693 chr22:41940476 POLR3H 1.0 14.25 0.62 2.41e-36 Vitiligo; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg00684032 chr4:1343700 KIAA1530 -0.33 -5.72 -0.3 2.38e-8 Obesity-related traits; LUSC cis rs2073300 0.826 rs6083136 chr20:23454188 A/G cg09953122 chr20:23471693 CST8 -0.61 -5.92 -0.31 7.97e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs8114671 0.585 rs2236271 chr20:33523840 G/T cg07148914 chr20:33460835 GGT7 -0.55 -8.49 -0.42 6.66e-16 Height; LUSC cis rs4776059 0.798 rs11855616 chr15:52874833 C/T cg22715398 chr15:52968154 KIAA1370 0.64 7.97 0.4 2.62e-14 Schizophrenia; LUSC cis rs10883723 0.962 rs10883726 chr10:104236276 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 12.06 0.55 4.66e-28 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9487051 0.735 rs351754 chr6:109537553 A/G cg01475377 chr6:109611718 NA 0.37 6.34 0.33 7.25e-10 Reticulocyte fraction of red cells; LUSC cis rs1595825 0.891 rs77032596 chr2:198603185 T/G cg19156104 chr2:198669113 PLCL1 -0.48 -5.77 -0.3 1.82e-8 Ulcerative colitis; LUSC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.6 8.91 0.44 3.44e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg18099408 chr3:52552593 STAB1 0.42 7.16 0.36 5.2e-12 Bipolar disorder; LUSC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg11645453 chr3:52864694 ITIH4 0.37 8.31 0.41 2.44e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg18876405 chr7:65276391 NA 0.58 9.57 0.46 2.55e-19 Aortic root size; LUSC cis rs2486288 0.656 rs11639349 chr15:45568260 C/T cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.78 -0.51 1.93e-23 Glomerular filtration rate; LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg03395511 chr6:291903 DUSP22 -0.46 -6.74 -0.35 6.91e-11 Menopause (age at onset); LUSC cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 8.04 0.4 1.62e-14 Colorectal cancer; LUSC trans rs7581030 0.517 rs7605066 chr2:71529331 C/T cg06465196 chr4:154387603 KIAA0922 0.42 6.04 0.31 4.18e-9 Testicular germ cell tumor; LUSC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg09021430 chr5:549028 NA -0.57 -7.7 -0.39 1.61e-13 Lung disease severity in cystic fibrosis; LUSC cis rs6076065 0.541 rs8118688 chr20:23320850 G/A cg11657817 chr20:23433608 CST11 0.4 7.4 0.38 1.13e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg04267008 chr7:1944627 MAD1L1 -0.67 -10.38 -0.49 4.64e-22 Bipolar disorder and schizophrenia; LUSC cis rs11048434 0.736 rs933462 chr12:9103665 T/G cg23795048 chr12:9217529 LOC144571 0.33 5.76 0.3 1.94e-8 Sjögren's syndrome; LUSC cis rs7615952 0.688 rs12638240 chr3:125541238 G/A cg05084668 chr3:125655381 ALG1L -0.59 -8.29 -0.41 2.76e-15 Blood pressure (smoking interaction); LUSC cis rs7246657 0.551 rs10419174 chr19:37605341 A/G cg23950597 chr19:37808831 NA -0.55 -6.01 -0.31 4.87e-9 Coronary artery calcification; LUSC cis rs79149102 0.850 rs78646589 chr15:75170580 C/T cg09165964 chr15:75287851 SCAMP5 -0.89 -6.39 -0.33 5.55e-10 Lung cancer; LUSC cis rs10197940 0.662 rs4467261 chr2:152281391 G/C cg06191203 chr2:152266755 RIF1 -0.52 -7.08 -0.36 8.51e-12 Lung cancer; LUSC cis rs9658691 0.646 rs2862834 chr10:90741374 A/G cg03111039 chr10:90751583 FAS;ACTA2 0.69 6.5 0.34 2.85e-10 Mosquito bite size; LUSC cis rs4380275 1.000 rs7562792 chr2:774469 T/C cg21665850 chr2:731073 NA 0.42 6.75 0.35 6.65e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg11584989 chr19:19387371 SF4 -0.6 -7.08 -0.36 8.81e-12 Bipolar disorder; LUSC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg17724175 chr1:150552817 MCL1 0.37 6.65 0.34 1.23e-10 Melanoma; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg04025307 chr7:1156635 C7orf50 0.37 5.68 0.3 2.91e-8 Longevity;Endometriosis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22828804 chr20:3140466 UBOX5;FASTKD5 -0.38 -6.51 -0.34 2.82e-10 Electrocardiographic conduction measures; LUSC cis rs11971779 0.680 rs1133067 chr7:139053069 G/T cg07862535 chr7:139043722 LUC7L2 0.57 7.28 0.37 2.44e-12 Diisocyanate-induced asthma; LUSC cis rs2760061 0.599 rs849903 chr1:228137659 T/C cg02753203 chr1:228287806 NA -0.65 -10.72 -0.51 3.15e-23 Diastolic blood pressure; LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg02951883 chr7:2050386 MAD1L1 -0.51 -9.01 -0.44 1.6e-17 Bipolar disorder and schizophrenia; LUSC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg10351095 chr21:47802916 PCNT 0.5 7.07 0.36 9.34e-12 Testicular germ cell tumor; LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.38 -0.42 1.51e-15 Obesity-related traits; LUSC trans rs7829975 0.714 rs4840362 chr8:8670082 C/G cg27411982 chr8:10470053 RP1L1 -0.45 -7.24 -0.37 3.11e-12 Mood instability; LUSC cis rs11098499 0.754 rs2964 chr4:120240131 T/C cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs7267979 1.000 rs6050542 chr20:25318879 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.57 -0.75 2.54e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1559088 0.847 rs10416218 chr19:33599127 T/C cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.03e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9487051 0.768 rs458185 chr6:109524074 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.81 -0.3 1.49e-8 Reticulocyte fraction of red cells; LUSC cis rs7178572 0.568 rs1823100 chr15:77402744 C/T cg22256960 chr15:77711686 NA -0.51 -8.02 -0.4 1.74e-14 Type 2 diabetes; LUSC cis rs10193935 0.901 rs62142561 chr2:42477808 G/C cg27598129 chr2:42591480 NA -0.59 -8.12 -0.41 9.26e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg20908204 chr19:46285434 DMPK 0.41 8.15 0.41 7.21e-15 Coronary artery disease; LUSC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg04352962 chr1:209979756 IRF6 0.5 6.74 0.35 7.02e-11 Cleft lip with or without cleft palate; LUSC trans rs11700980 1.000 rs58491443 chr21:30056039 G/A cg05609335 chr17:75789393 NA 0.41 6.02 0.31 4.71e-9 QRS complex (12-leadsum); LUSC trans rs61931739 0.517 rs1817760 chr12:34106060 A/G cg13010199 chr12:38710504 ALG10B 0.56 8.59 0.43 3.38e-16 Morning vs. evening chronotype; LUSC cis rs765787 0.530 rs55771002 chr15:45541566 T/C cg25801113 chr15:45476975 SHF 0.34 7.04 0.36 1.13e-11 Uric acid levels; LUSC cis rs6964587 1.000 rs2269727 chr7:91752690 C/A cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.17e-8 Breast cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00608362 chr4:128802003 PLK4 -0.46 -6.99 -0.36 1.53e-11 Electrocardiographic conduction measures; LUSC cis rs826838 0.709 rs4882355 chr12:38721462 A/T cg13010199 chr12:38710504 ALG10B 0.46 7.15 0.36 5.43e-12 Heart rate; LUSC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.61 0.43 2.95e-16 Menarche (age at onset); LUSC trans rs11039798 0.699 rs7120775 chr11:48266736 C/G cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.34 9.51e-11 Axial length; LUSC cis rs7605827 0.866 rs13016989 chr2:15514338 T/A cg19274914 chr2:15703543 NA 0.46 8.81 0.43 6.94e-17 Educational attainment (years of education); LUSC cis rs9646944 0.501 rs2110736 chr2:103050855 T/C cg20060108 chr2:102954350 IL1RL1 0.48 6.59 0.34 1.67e-10 Blood protein levels; LUSC trans rs2204008 0.628 rs10876106 chr12:37990767 A/G cg06521331 chr12:34319734 NA -0.4 -6.32 -0.33 8.19e-10 Bladder cancer; LUSC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg06634786 chr22:41940651 POLR3H -0.57 -6.44 -0.33 4.11e-10 Vitiligo; LUSC trans rs1814175 0.645 rs1818895 chr11:50031523 G/T cg03929089 chr4:120376271 NA -0.95 -16.65 -0.67 9.25e-46 Height; LUSC trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg07211511 chr3:129823064 LOC729375 -1.27 -21.47 -0.76 7.64e-65 Blood pressure (smoking interaction); LUSC cis rs62400317 0.859 rs11966878 chr6:45328265 C/T cg18551225 chr6:44695536 NA 0.43 6.97 0.36 1.72e-11 Total body bone mineral density; LUSC cis rs2970818 0.831 rs1029769 chr12:4645448 T/C cg11146114 chr12:4671731 NA -0.56 -5.95 -0.31 6.96e-9 Phosphorus levels; LUSC cis rs2742417 1.000 rs2742452 chr3:45765708 C/T cg09608765 chr3:45636137 LIMD1 -0.38 -7.49 -0.38 6.08e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg03036452 chr22:46663545 TTC38 0.54 5.89 0.31 9.38e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.88 0.4 4.66e-14 Total body bone mineral density; LUSC cis rs5758511 0.596 rs55644935 chr22:42666069 A/G cg00645731 chr22:42541494 CYP2D7P1 0.54 9.65 0.47 1.39e-19 Birth weight; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10524888 chr4:39529563 UGDH -0.46 -6.05 -0.31 3.94e-9 Bipolar disorder and schizophrenia; LUSC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg17173187 chr15:85201210 NMB 0.35 6.29 0.33 9.81e-10 Schizophrenia; LUSC cis rs6138458 1.000 rs6114984 chr20:24976610 A/G cg26195577 chr20:24973756 C20orf3 1.11 18.48 0.71 5e-53 Blood protein levels; LUSC cis rs11642862 1.000 rs11642603 chr16:30886221 C/G cg02466173 chr16:30829666 NA -0.69 -6.93 -0.35 2.24e-11 Tonsillectomy; LUSC cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg23029597 chr12:123009494 RSRC2 -0.73 -9.72 -0.47 7.96e-20 Body mass index; LUSC cis rs9297145 0.761 rs112155177 chr7:98747963 C/T cg05967295 chr7:98741636 SMURF1 0.93 13.68 0.6 4.08e-34 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg18225595 chr11:63971243 STIP1 0.56 7.54 0.38 4.57e-13 Mean platelet volume; LUSC cis rs694739 0.628 rs508168 chr11:64135435 G/A cg26898376 chr11:64110657 CCDC88B 0.33 6.16 0.32 2.06e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg03929089 chr4:120376271 NA -0.94 -16.25 -0.66 3.8e-44 Height; LUSC cis rs694739 1.000 rs499425 chr11:64105929 A/G cg02228329 chr11:64053129 BAD;GPR137 -0.53 -7.75 -0.39 1.13e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs853679 0.556 rs13200214 chr6:28017250 C/T cg01620082 chr3:125678407 NA -0.78 -7.18 -0.37 4.56e-12 Depression; LUSC cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.84 -0.3 1.24e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7223966 1.000 rs7220821 chr17:61704147 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.46 0.38 7.44e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs11098499 0.954 rs71629403 chr4:120372567 C/T cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs10504073 0.584 rs17642664 chr8:49942945 A/G cg00325661 chr8:49890786 NA 0.7 11.09 0.52 1.54e-24 Blood metabolite ratios; LUSC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg17376030 chr22:41985996 PMM1 0.51 6.31 0.33 8.73e-10 Vitiligo; LUSC cis rs4474465 0.688 rs4457782 chr11:78284733 A/G cg27205649 chr11:78285834 NARS2 0.55 6.69 0.34 9.59e-11 Alzheimer's disease (survival time); LUSC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg27170947 chr2:26402098 FAM59B -0.65 -9.52 -0.46 3.75e-19 Gut microbiome composition (summer); LUSC cis rs73200209 0.744 rs11615877 chr12:116709800 C/T cg01776926 chr12:116560359 MED13L -0.49 -5.83 -0.3 1.29e-8 Total body bone mineral density; LUSC trans rs1814175 0.645 rs28436748 chr11:50046422 G/A cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs10504229 0.861 rs67966192 chr8:58188172 A/C cg22535103 chr8:58192502 C8orf71 -0.75 -9.42 -0.46 7.89e-19 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg18252515 chr7:66147081 NA -1.24 -14.24 -0.61 2.72e-36 Diabetic kidney disease; LUSC cis rs34779708 0.931 rs11596502 chr10:35387187 A/C cg03585969 chr10:35415529 CREM 0.65 9.46 0.46 5.6e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6840360 0.550 rs6853955 chr4:152510806 G/A cg22705602 chr4:152727874 NA -0.32 -6.39 -0.33 5.71e-10 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13732083 chr21:47605072 C21orf56 0.42 6.21 0.32 1.55e-9 Testicular germ cell tumor; LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg11645453 chr3:52864694 ITIH4 0.34 7.77 0.39 9.51e-14 Bipolar disorder; LUSC cis rs868036 0.681 rs28688285 chr15:68110297 T/C cg24579218 chr15:68104479 NA -0.41 -6.56 -0.34 2.05e-10 Restless legs syndrome; LUSC cis rs10754283 0.557 rs1215508 chr1:90088697 C/T cg21401794 chr1:90099060 LRRC8C 0.54 7.67 0.39 1.86e-13 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2667011 0.756 rs2667023 chr2:160835399 C/T cg06573604 chr2:160760825 LY75 -0.48 -6.16 -0.32 2.09e-9 Bilirubin levels; LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg07217954 chr7:1067459 C7orf50 0.52 5.67 0.3 3.02e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs208520 0.690 rs207119 chr6:66786408 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC cis rs7809950 0.678 rs2237659 chr7:106847492 G/T cg23024343 chr7:107201750 COG5 0.62 8.55 0.42 4.45e-16 Coronary artery disease; LUSC cis rs2777491 0.872 rs7176588 chr15:41588872 C/T cg18705301 chr15:41695430 NDUFAF1 -0.7 -13.49 -0.59 2.01e-33 Ulcerative colitis; LUSC cis rs56399783 0.901 rs6967664 chr7:2816384 A/G cg19731401 chr7:2775893 GNA12 0.64 8.52 0.42 5.68e-16 Childhood ear infection; LUSC cis rs1443512 0.773 rs2366146 chr12:54331002 G/A cg17410650 chr12:54324560 NA -0.58 -10.51 -0.5 1.61e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1775715 0.707 rs2778669 chr10:32161541 C/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.59 0.34 1.68e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6061231 0.505 rs62199217 chr20:60929539 G/A cg22601191 chr20:60968625 CABLES2 0.46 6.55 0.34 2.19e-10 Colorectal cancer; LUSC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.62 0.47 1.72e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg13206674 chr6:150067644 NUP43 0.63 10.48 0.5 2.12e-22 Lung cancer; LUSC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg10169327 chr19:45448959 APOC2 0.31 6.66 0.34 1.15e-10 Blood protein levels; LUSC cis rs240764 0.658 rs6925823 chr6:101179273 C/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.42 -0.33 4.68e-10 Neuroticism; LUSC cis rs7216064 1.000 rs9913471 chr17:65874495 C/T cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs656319 0.605 rs60278284 chr8:10003210 G/C cg27411982 chr8:10470053 RP1L1 -0.4 -5.99 -0.31 5.48e-9 Myopia (pathological); LUSC cis rs12579753 0.879 rs1986537 chr12:82156475 G/C cg21231944 chr12:82153410 PPFIA2 -0.39 -6.2 -0.32 1.7e-9 Resting heart rate; LUSC cis rs4474465 0.833 rs6592792 chr11:78271614 A/C cg27205649 chr11:78285834 NARS2 0.54 6.1 0.32 2.93e-9 Alzheimer's disease (survival time); LUSC cis rs1538970 0.669 rs3219476 chr1:45802670 A/C cg05343316 chr1:45956843 TESK2 -0.41 -5.89 -0.31 9.59e-9 Platelet count; LUSC cis rs2996428 0.667 rs17412654 chr1:3758493 T/C cg17848003 chr1:3704513 LRRC47 0.32 5.81 0.3 1.46e-8 Red cell distribution width; LUSC cis rs1062753 0.961 rs9620007 chr22:42405657 C/G cg22189786 chr22:42395067 WBP2NL 0.43 5.75 0.3 2.05e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg06873352 chr17:61820015 STRADA 0.51 8.49 0.42 6.93e-16 Prudent dietary pattern; LUSC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC trans rs10435719 0.902 rs7006538 chr8:11804982 A/G cg27411982 chr8:10470053 RP1L1 0.4 6.17 0.32 1.98e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs10484885 0.887 rs114928443 chr6:90602455 A/T cg13799429 chr6:90582589 CASP8AP2 -0.79 -8.48 -0.42 7.58e-16 QRS interval (sulfonylurea treatment interaction); LUSC cis rs911555 0.723 rs4906324 chr14:103923099 A/G cg12935359 chr14:103987150 CKB 0.66 10.79 0.51 1.81e-23 Intelligence (multi-trait analysis); LUSC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg18225595 chr11:63971243 STIP1 0.5 6.17 0.32 2e-9 Mean platelet volume; LUSC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg15448220 chr1:150897856 SETDB1 0.42 6.1 0.32 2.93e-9 Melanoma; LUSC cis rs1322512 1.000 rs2250632 chr6:153011126 C/A cg27316956 chr6:152958899 SYNE1 0.35 6.07 0.32 3.47e-9 Tonometry; LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg08219700 chr8:58056026 NA 0.45 6.14 0.32 2.28e-9 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg10360139 chr7:1886902 MAD1L1 -0.4 -6.09 -0.32 3.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs1577917 0.917 rs4707226 chr6:86527828 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs981844 1.000 rs2606332 chr4:154655372 G/A cg14289246 chr4:154710475 SFRP2 0.5 6.25 0.32 1.28e-9 Response to statins (LDL cholesterol change); LUSC cis rs868036 0.609 rs16951304 chr15:68089618 T/C cg08079166 chr15:68083412 MAP2K5 0.49 8.17 0.41 6.23e-15 Restless legs syndrome; LUSC cis rs6669072 0.647 rs814544 chr1:91241693 G/A cg08895590 chr1:91227319 NA -0.38 -8.64 -0.43 2.43e-16 Cognitive function; LUSC cis rs7659604 0.540 rs4833769 chr4:122672970 A/C cg19748678 chr4:122722346 EXOSC9 0.4 5.93 0.31 7.37e-9 Type 2 diabetes; LUSC trans rs17685 0.740 rs4732514 chr7:75613998 C/T cg19862616 chr7:65841803 NCRNA00174 -0.94 -15.13 -0.64 9.37e-40 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs754466 0.580 rs10824576 chr10:79566040 G/C cg17075019 chr10:79541650 NA -0.72 -10.99 -0.52 3.57e-24 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs6502050 0.835 rs3924780 chr17:80112978 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs981844 0.666 rs7691303 chr4:154684198 T/C cg14289246 chr4:154710475 SFRP2 -0.52 -7.43 -0.38 9.38e-13 Response to statins (LDL cholesterol change); LUSC cis rs9309473 1.000 rs1403284 chr2:73726662 A/G cg20560298 chr2:73613845 ALMS1 0.52 7.62 0.38 2.63e-13 Metabolite levels; LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7843479 0.601 rs3824338 chr8:21864540 A/C cg17168535 chr8:21777572 XPO7 0.78 13.9 0.61 5.57e-35 Mean corpuscular volume; LUSC cis rs11641365 0.517 rs73262667 chr16:88779753 C/T cg06304787 chr16:88772962 CTU2;RNF166 0.63 6.66 0.34 1.13e-10 Autism spectrum disorder-related traits; LUSC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg17554472 chr22:41940697 POLR3H -0.48 -5.76 -0.3 1.89e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs34734847 0.787 rs695949 chr12:121149736 A/G cg27246729 chr12:121163418 ACADS 0.42 6.59 0.34 1.7e-10 Mean corpuscular volume; LUSC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg21963583 chr11:68658836 MRPL21 0.55 8.43 0.42 1.07e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg14558114 chr2:88469736 THNSL2 0.79 7.08 0.36 8.4e-12 Plasma clusterin levels; LUSC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg10018233 chr7:150070692 REPIN1 0.4 6.65 0.34 1.23e-10 Blood protein levels;Circulating chemerin levels; LUSC trans rs3942852 0.910 rs11603850 chr11:48140900 G/A cg03929089 chr4:120376271 NA -0.57 -6.44 -0.33 4.12e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs1178968 1.000 rs4717751 chr7:72750627 G/A cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.84e-13 Triglyceride levels; LUSC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg26587870 chr6:27730563 NA -0.63 -5.96 -0.31 6.45e-9 Depression; LUSC cis rs12618769 1.000 rs3769693 chr2:99259346 T/G cg10123293 chr2:99228465 UNC50 0.43 5.96 0.31 6.29e-9 Bipolar disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23864632 chr19:47220401 PRKD2 -0.41 -5.97 -0.31 5.93e-9 Electrocardiographic conduction measures; LUSC trans rs1493916 0.905 rs4239383 chr18:31401066 T/C cg13755796 chr4:20253514 NA -0.43 -6.8 -0.35 4.98e-11 Life satisfaction; LUSC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg03929089 chr4:120376271 NA -1.04 -20.42 -0.75 1.02e-60 Height; LUSC cis rs3020736 0.500 rs6002604 chr22:42493081 A/T cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg05368731 chr17:41323189 NBR1 0.94 16.0 0.66 3.44e-43 Menopause (age at onset); LUSC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg15839431 chr19:19639596 YJEFN3 -0.44 -6.11 -0.32 2.7e-9 Tonsillectomy; LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.81e-10 Bipolar disorder; LUSC cis rs1215050 0.743 rs6532692 chr4:98648005 C/A cg05340658 chr4:99064831 C4orf37 -0.41 -6.45 -0.33 4.01e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs701145 0.537 rs357479 chr3:153891489 A/G cg10247383 chr3:153839028 SGEF -0.61 -5.74 -0.3 2.09e-8 Coronary artery disease; LUSC cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg07828340 chr4:882639 GAK 1.1 11.46 0.53 7.38e-26 Intelligence (multi-trait analysis); LUSC trans rs12692738 0.526 rs355862 chr2:165630100 A/G cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs9399135 0.935 rs11754504 chr6:135321509 C/T cg22676075 chr6:135203613 NA 0.48 7.48 0.38 6.5e-13 Red blood cell count; LUSC trans rs2243480 1.000 rs2420171 chr7:65637760 T/C cg10756647 chr7:56101905 PSPH -0.82 -8.16 -0.41 6.72e-15 Diabetic kidney disease; LUSC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.86 0.4 5.33e-14 Parkinson's disease; LUSC cis rs2859741 0.967 rs534131 chr1:37484237 T/C cg09363841 chr1:37513479 NA -0.39 -7.71 -0.39 1.44e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC trans rs11098499 1.000 rs11726229 chr4:120211580 C/T cg25214090 chr10:38739885 LOC399744 0.45 6.49 0.33 3.17e-10 Corneal astigmatism; LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC cis rs1577917 1.000 rs6914463 chr6:86653415 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.66e-9 Response to antipsychotic treatment; LUSC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg00310523 chr12:86230176 RASSF9 0.51 9.73 0.47 7.48e-20 Major depressive disorder; LUSC cis rs600626 0.588 rs10793124 chr11:75452267 C/G cg24262691 chr11:75473276 NA 0.5 6.19 0.32 1.74e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1953600 0.870 rs2788295 chr10:81941007 C/G cg00277334 chr10:82204260 NA 0.45 7.08 0.36 8.35e-12 Sarcoidosis; LUSC cis rs9303280 0.870 rs6503524 chr17:38069809 C/T cg19468946 chr17:37922297 IKZF3 0.39 6.24 0.32 1.3e-9 Self-reported allergy; LUSC trans rs12692738 0.526 rs650330 chr2:165624861 G/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9467773 0.836 rs1624440 chr6:26433329 G/A cg11502198 chr6:26597334 ABT1 -0.47 -6.68 -0.34 9.78e-11 Intelligence (multi-trait analysis); LUSC cis rs7799006 0.862 rs3757439 chr7:2272122 C/T cg12823233 chr7:2316876 SNX8 -0.35 -6.12 -0.32 2.67e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg00376283 chr12:123451042 ABCB9 -0.66 -9.37 -0.46 1.1e-18 Neutrophil percentage of white cells; LUSC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg01191920 chr7:158217561 PTPRN2 -0.59 -12.15 -0.55 2.3e-28 Obesity-related traits; LUSC cis rs757278 0.526 rs1366912 chr7:117316601 A/G cg10524701 chr7:117356490 CTTNBP2 0.4 5.7 0.3 2.7e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs7246967 0.673 rs56663398 chr19:22820200 C/T cg23217946 chr19:22817039 ZNF492 0.43 6.0 0.31 5.14e-9 Bronchopulmonary dysplasia; LUSC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg23649088 chr2:200775458 C2orf69 0.54 7.35 0.37 1.58e-12 Schizophrenia; LUSC cis rs60843830 0.661 rs62116681 chr2:104197 A/T cg25945732 chr2:264204 ACP1;SH3YL1 0.45 6.69 0.34 9.44e-11 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9361491 0.657 rs1180824 chr6:79433523 G/A cg05283184 chr6:79620031 NA -0.33 -5.87 -0.31 1.07e-8 Intelligence (multi-trait analysis); LUSC cis rs13082711 0.519 rs13091109 chr3:27229125 G/A cg02860705 chr3:27208620 NA 0.61 10.37 0.49 5.19e-22 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -11.66 -0.54 1.38e-26 Chronic sinus infection; LUSC cis rs11971779 0.553 rs36002669 chr7:139113161 T/A cg23387468 chr7:139079360 LUC7L2 0.42 6.29 0.33 1e-9 Diisocyanate-induced asthma; LUSC cis rs11105298 0.891 rs12369195 chr12:89934972 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.52 -7.04 -0.36 1.13e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg18225595 chr11:63971243 STIP1 0.5 6.19 0.32 1.8e-9 Mean platelet volume; LUSC cis rs6429082 0.521 rs704711 chr1:235629802 G/A cg26050004 chr1:235667680 B3GALNT2 0.8 14.05 0.61 1.44e-35 Adiposity; LUSC trans rs6600671 0.967 rs11249347 chr1:121188347 G/T cg00646200 chr1:148855367 NA 0.46 7.33 0.37 1.77e-12 Hip geometry; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.52 0.53 4.39e-26 Prudent dietary pattern; LUSC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs17401966 0.931 rs11121545 chr1:10411211 A/G cg19773385 chr1:10388646 KIF1B -0.57 -9.73 -0.47 7.08e-20 Hepatocellular carcinoma; LUSC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 9.91e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg24399712 chr22:39784796 NA 0.6 9.86 0.47 2.67e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg05025164 chr4:1340916 KIAA1530 0.46 7.06 0.36 9.77e-12 Obesity-related traits; LUSC cis rs4308124 0.679 rs7600458 chr2:111963590 G/C cg04571233 chr2:111982156 NA -0.5 -6.55 -0.34 2.11e-10 Vitiligo; LUSC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg08048268 chr3:133502702 NA -0.46 -8.9 -0.44 3.54e-17 Iron status biomarkers; LUSC cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg08807101 chr21:30365312 RNF160 0.64 9.91 0.48 1.79e-20 Pancreatic cancer; LUSC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg05084668 chr3:125655381 ALG1L -0.51 -7.12 -0.36 6.65e-12 Blood pressure (smoking interaction); LUSC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg24562669 chr7:97807699 LMTK2 -0.35 -6.21 -0.32 1.6e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9443189 0.570 rs9343316 chr6:76411800 G/A cg01950844 chr6:76311363 SENP6 0.68 6.84 0.35 3.85e-11 Prostate cancer; LUSC cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg05283184 chr6:79620031 NA -0.56 -11.49 -0.53 5.69e-26 Intelligence (multi-trait analysis); LUSC cis rs16976116 0.901 rs2899581 chr15:55491643 T/C cg11288833 chr15:55489084 RSL24D1 0.49 5.9 0.31 9.16e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10791097 0.667 rs4937584 chr11:130741761 A/G cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs11098499 0.913 rs35271032 chr4:120156659 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs9633740 1.000 rs10749609 chr10:82249752 G/A cg01528321 chr10:82214614 TSPAN14 1.03 11.38 0.53 1.44e-25 Post bronchodilator FEV1; LUSC cis rs9457247 0.565 rs2239824 chr6:167511799 T/A cg06454157 chr6:167490870 NA -0.25 -5.71 -0.3 2.52e-8 Crohn's disease; LUSC cis rs748404 0.578 rs4547312 chr15:43632138 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.44 0.42 9.9e-16 Lung cancer; LUSC cis rs4629710 0.592 rs66533103 chr6:131531016 C/T cg12606694 chr6:131520996 AKAP7 0.62 9.17 0.45 4.95e-18 Multiple myeloma (IgH translocation); LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.0 -0.68 3.84e-47 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.03 0.44 1.38e-17 Prudent dietary pattern; LUSC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.16 0.36 5.12e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg12560992 chr17:57184187 TRIM37 0.85 15.3 0.64 2e-40 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg11494091 chr17:61959527 GH2 0.64 13.62 0.6 6.4e-34 Prudent dietary pattern; LUSC cis rs2777491 0.957 rs2015781 chr15:41648967 C/G cg18705301 chr15:41695430 NDUFAF1 -0.74 -14.14 -0.61 6.46e-36 Ulcerative colitis; LUSC cis rs7267979 0.727 rs2474765 chr20:25245950 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.73 14.75 0.63 2.86e-38 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg04824913 chr4:887549 GAK 0.73 9.91 0.48 1.82e-20 Systemic sclerosis; LUSC cis rs9715521 0.775 rs11723682 chr4:59851969 C/T cg11281224 chr4:60001000 NA -0.47 -6.46 -0.33 3.59e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13732083 chr21:47605072 C21orf56 0.4 5.76 0.3 1.93e-8 Testicular germ cell tumor; LUSC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg00784671 chr22:46762841 CELSR1 -0.46 -5.75 -0.3 1.97e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg22681709 chr2:178499509 PDE11A -0.51 -9.25 -0.45 2.71e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9303401 0.659 rs16943176 chr17:56769887 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs3126085 1.000 rs12567463 chr1:152180128 T/A cg03465714 chr1:152285911 FLG 0.42 5.79 0.3 1.65e-8 Atopic dermatitis; LUSC cis rs4974559 0.740 rs11933854 chr4:1315172 G/A cg02980000 chr4:1222292 CTBP1 0.84 9.43 0.46 7.14e-19 Systolic blood pressure; LUSC cis rs7647973 1.000 rs6446262 chr3:49401153 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.28 0.37 2.47e-12 Menarche (age at onset); LUSC cis rs2439831 0.681 rs7168940 chr15:43633334 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.08 15.19 0.64 5.27e-40 Lung cancer in ever smokers; LUSC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg06618935 chr21:46677482 NA -0.38 -7.57 -0.38 3.79e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 1.93e-9 Life satisfaction; LUSC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.51 0.62 2.44e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs73206853 0.764 rs970228 chr12:111070169 G/C cg12870014 chr12:110450643 ANKRD13A 0.69 7.58 0.38 3.37e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1670533 1.000 rs1670533 chr4:1078187 G/A cg02018176 chr4:1364513 KIAA1530 0.46 6.53 0.34 2.46e-10 Recombination rate (females); LUSC cis rs7216064 1.000 rs6504555 chr17:65940727 A/G cg12091567 chr17:66097778 LOC651250 0.71 9.52 0.46 3.53e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg17178900 chr1:205818956 PM20D1 0.79 13.18 0.58 3.12e-32 Menarche (age at onset); LUSC cis rs7223966 0.921 rs7225092 chr17:61864005 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.97 0.36 1.73e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9341808 0.754 rs1324121 chr6:80946077 A/G cg08355045 chr6:80787529 NA 0.56 9.66 0.47 1.22e-19 Sitting height ratio; LUSC cis rs34779708 0.931 rs4934697 chr10:35287192 C/T cg04310649 chr10:35416472 CREM -0.43 -6.54 -0.34 2.35e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg12615879 chr12:58013172 SLC26A10 -0.29 -5.97 -0.31 5.93e-9 Multiple sclerosis; LUSC cis rs61990749 0.544 rs1477259 chr14:78256138 C/G cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.45 0.33 3.84e-10 Fibroblast growth factor basic levels; LUSC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg06238570 chr21:40685208 BRWD1 -0.63 -10.65 -0.5 5.32e-23 Cognitive function; LUSC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg27121462 chr16:89883253 FANCA 0.54 8.65 0.43 2.27e-16 Vitiligo; LUSC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg12311346 chr5:56204834 C5orf35 -0.68 -9.71 -0.47 8.36e-20 Type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07727872 chr19:33463030 C19orf40;CCDC123 0.42 6.33 0.33 8.11e-10 Triglycerides; LUSC cis rs10905065 0.833 rs6602259 chr10:5844628 C/T cg11519256 chr10:5708881 ASB13 0.38 5.77 0.3 1.82e-8 Menopause (age at onset); LUSC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.36 -5.96 -0.31 6.37e-9 Personality dimensions; LUSC cis rs2348418 0.647 rs10843210 chr12:28728733 T/C cg13890972 chr12:28721907 NA -0.39 -6.71 -0.34 8.21e-11 Lung function (FVC);Lung function (FEV1); LUSC trans rs561341 1.000 rs473356 chr17:30321762 G/C cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs6696846 0.936 rs1042831 chr1:205043250 G/C cg21643547 chr1:205240462 TMCC2 -0.39 -6.88 -0.35 3.02e-11 Red blood cell count; LUSC cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.44e-8 Extrinsic epigenetic age acceleration; LUSC cis rs983392 0.803 rs56189574 chr11:59933492 A/G cg00673646 chr11:59950525 MS4A6A -0.36 -5.79 -0.3 1.65e-8 Alzheimer's disease (late onset); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg08749455 chr11:72492538 STARD10 -0.54 -6.77 -0.35 5.68e-11 Cognitive function;Information processing speed; LUSC cis rs6695223 0.571 rs4907133 chr1:85538947 A/G cg11262906 chr1:85462892 MCOLN2 -0.57 -6.31 -0.33 8.97e-10 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg23887609 chr12:130822674 PIWIL1 0.49 7.27 0.37 2.65e-12 Menopause (age at onset); LUSC cis rs2760061 0.545 rs1636196 chr1:228204030 A/G cg02753203 chr1:228287806 NA 1.0 19.71 0.73 6.59e-58 Diastolic blood pressure; LUSC cis rs921665 0.831 rs11682390 chr2:3187698 G/A cg02624386 chr2:3182749 NA 0.61 6.78 0.35 5.34e-11 World class endurance athleticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16293131 chr17:79885702 LOC92659;MAFG -0.4 -6.0 -0.31 5.21e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.49 -0.42 6.77e-16 Total body bone mineral density; LUSC cis rs911119 1.000 rs1010117 chr20:23608421 G/C cg16589663 chr20:23618590 CST3 0.59 6.96 0.36 1.8e-11 Chronic kidney disease; LUSC cis rs8017423 0.904 rs7147212 chr14:90697809 A/C cg04374321 chr14:90722782 PSMC1 0.73 11.65 0.54 1.49e-26 Mortality in heart failure; LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs3740713 0.669 rs2896526 chr11:18419806 A/G cg23797887 chr11:18477753 LDHAL6A -0.49 -5.95 -0.31 6.69e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7647973 0.626 rs11720705 chr3:49753788 A/G cg03060546 chr3:49711283 APEH 0.65 7.62 0.38 2.68e-13 Menarche (age at onset); LUSC cis rs9359856 0.956 rs6933010 chr6:90299879 G/C cg13799429 chr6:90582589 CASP8AP2 0.56 6.44 0.33 4.08e-10 Bipolar disorder; LUSC cis rs4776059 1.000 rs35372377 chr15:52882281 G/A cg22715398 chr15:52968154 KIAA1370 -0.7 -10.02 -0.48 8.05e-21 Schizophrenia; LUSC cis rs2041895 0.509 rs7970139 chr12:107312430 T/C cg13944111 chr12:107296891 NA 0.38 6.63 0.34 1.32e-10 Glaucoma (low intraocular pressure); LUSC cis rs9462027 0.651 rs1543559 chr6:34784104 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.74 -0.3 2.13e-8 Systemic lupus erythematosus; LUSC trans rs10435719 0.764 rs10103485 chr8:11787563 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.01 0.31 4.75e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1858037 0.867 rs57913336 chr2:65587619 G/A cg08085232 chr2:65598271 SPRED2 -0.4 -5.95 -0.31 6.88e-9 Rheumatoid arthritis; LUSC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg24881330 chr22:46731750 TRMU 0.86 7.79 0.39 8.78e-14 LDL cholesterol;Cholesterol, total; LUSC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg15147215 chr3:52552868 STAB1 -0.3 -5.84 -0.3 1.22e-8 Electroencephalogram traits; LUSC cis rs6665290 0.904 rs12409428 chr1:227189969 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -40.05 -0.91 1.39e-129 Myeloid white cell count; LUSC cis rs12145833 0.596 rs12123491 chr1:243297924 C/G cg02356786 chr1:243265016 LOC731275 0.71 6.64 0.34 1.29e-10 Obesity (early onset extreme); LUSC cis rs1153858 0.945 rs2467854 chr15:45701597 A/G cg14582100 chr15:45693742 SPATA5L1 0.56 10.09 0.48 4.35e-21 Homoarginine levels; LUSC cis rs8016982 0.633 rs72695758 chr14:81720146 T/C cg01989461 chr14:81687754 GTF2A1 0.71 12.67 0.57 2.56e-30 Schizophrenia; LUSC cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg23711669 chr6:146136114 FBXO30 0.82 14.76 0.63 2.62e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg17340268 chr14:105411764 AHNAK2 -0.41 -6.63 -0.34 1.34e-10 Rheumatoid arthritis; LUSC cis rs6967385 0.604 rs10258470 chr7:12331516 A/G cg06484146 chr7:12443880 VWDE 0.41 6.54 0.34 2.26e-10 Response to taxane treatment (placlitaxel); LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg16649755 chr6:88412160 NCRNA00120;AKIRIN2 0.37 7.13 0.36 6.14e-12 Tuberculosis; LUSC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg05110241 chr16:68378359 PRMT7 -0.58 -6.72 -0.35 7.89e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2073300 0.609 rs6137941 chr20:23400848 G/A cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Metabolite levels (small molecules and protein measures); LUSC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg12560992 chr17:57184187 TRIM37 0.9 17.71 0.7 6.08e-50 Intelligence (multi-trait analysis); LUSC cis rs2303282 0.716 rs2587866 chr16:56403899 C/T cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.46 7.14 0.36 5.71e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg15704280 chr7:45808275 SEPT13 -0.85 -14.29 -0.62 1.69e-36 Height; LUSC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg11764359 chr7:65958608 NA 0.48 6.03 0.31 4.34e-9 Aortic root size; LUSC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.27e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg14895029 chr7:2775587 GNA12 -0.36 -5.87 -0.31 1.08e-8 Height; LUSC cis rs9905704 0.647 rs2286299 chr17:57043367 T/G cg12560992 chr17:57184187 TRIM37 0.58 9.31 0.45 1.76e-18 Testicular germ cell tumor; LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg13010199 chr12:38710504 ALG10B 0.64 9.77 0.47 5.43e-20 Drug-induced liver injury (flucloxacillin); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14454942 chr6:8064764 MUTED -0.49 -6.37 -0.33 6.37e-10 Hepatitis; LUSC cis rs317689 0.690 rs10878947 chr12:69642683 A/T cg20891283 chr12:69753455 YEATS4 0.44 5.84 0.3 1.24e-8 Response to diuretic therapy; LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg22963979 chr7:1858916 MAD1L1 -0.47 -6.91 -0.35 2.51e-11 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.516 rs1866994 chr8:57990092 A/C cg11062466 chr8:58055876 NA 0.39 5.82 0.3 1.37e-8 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.959 rs12201739 chr6:86720739 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.04 -0.36 1.09e-11 Response to antipsychotic treatment; LUSC cis rs13082711 0.911 rs73046191 chr3:27454398 T/A cg02860705 chr3:27208620 NA 0.5 8.51 0.42 6.09e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg15485101 chr11:133734466 NA 0.41 7.37 0.37 1.31e-12 Childhood ear infection; LUSC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg04539111 chr16:67997858 SLC12A4 -0.38 -5.74 -0.3 2.17e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs9650657 0.740 rs2277130 chr8:10677601 G/C cg27411982 chr8:10470053 RP1L1 -0.4 -6.43 -0.33 4.33e-10 Neuroticism; LUSC cis rs4654899 0.643 rs2053981 chr1:21227083 G/A cg01072550 chr1:21505969 NA -0.55 -8.28 -0.41 2.93e-15 Superior frontal gyrus grey matter volume; LUSC trans rs11098499 0.657 rs7664458 chr4:120371967 A/G cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs13256369 0.802 rs2280560 chr8:8560602 C/T cg06671706 chr8:8559999 CLDN23 0.5 6.46 0.33 3.62e-10 Obesity-related traits; LUSC cis rs2637266 0.626 rs2588329 chr10:78552782 C/T cg18941641 chr10:78392320 NA 0.37 6.9 0.35 2.59e-11 Pulmonary function; LUSC cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.66 0.57 2.9e-30 Motion sickness; LUSC cis rs1878931 0.535 rs7188903 chr16:3412861 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.61 8.35 0.42 1.8e-15 Body mass index (adult); LUSC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18404041 chr3:52824283 ITIH1 -0.52 -9.93 -0.48 1.52e-20 Bipolar disorder; LUSC cis rs2880765 0.805 rs11858817 chr15:86031260 C/T cg13263323 chr15:86062960 AKAP13 -0.35 -5.72 -0.3 2.38e-8 Coronary artery disease; LUSC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg06287003 chr12:125626642 AACS -0.39 -6.39 -0.33 5.71e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2625529 0.668 rs72733369 chr15:72567260 G/A cg16672083 chr15:72433130 SENP8 -0.49 -7.11 -0.36 6.98e-12 Red blood cell count; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.68 10.47 0.5 2.3e-22 Lymphocyte counts; LUSC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg10295955 chr4:187884368 NA -1.01 -22.15 -0.77 1.61e-67 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.08e-10 Aortic root size; LUSC cis rs10484885 0.752 rs72921948 chr6:90582560 T/C cg13799429 chr6:90582589 CASP8AP2 -0.98 -13.86 -0.6 7.72e-35 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.08 -0.36 8.32e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9807841 0.670 rs2738042 chr19:10790143 C/G cg09936142 chr19:10668400 KRI1 -0.42 -6.59 -0.34 1.69e-10 Inflammatory skin disease; LUSC cis rs10045504 0.502 rs17352751 chr5:38737836 G/A cg15396434 chr5:38725168 NA -0.51 -5.65 -0.3 3.39e-8 Night sleep phenotypes; LUSC cis rs7584330 0.737 rs1497128 chr2:238369211 A/G cg14458575 chr2:238380390 NA 0.66 11.7 0.54 1.01e-26 Prostate cancer; LUSC cis rs1801251 1.000 rs283477 chr2:233649427 A/G cg08000102 chr2:233561755 GIGYF2 0.75 11.72 0.54 8.09e-27 Coronary artery disease; LUSC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs10782582 0.609 rs1628063 chr1:76391646 A/G cg10523679 chr1:76189770 ACADM -0.45 -6.55 -0.34 2.23e-10 Daytime sleep phenotypes; LUSC cis rs950169 0.887 rs35986397 chr15:84955107 G/A cg17173187 chr15:85201210 NMB 0.37 6.43 0.33 4.54e-10 Schizophrenia; LUSC cis rs66887589 0.967 rs6844263 chr4:120433807 A/G cg09307838 chr4:120376055 NA 0.49 7.57 0.38 3.72e-13 Diastolic blood pressure; LUSC cis rs8051149 0.793 rs12445334 chr16:87871213 G/A cg01412419 chr16:87856264 NA 0.46 6.67 0.34 1.04e-10 Blood metabolite levels; LUSC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 8.86 0.44 4.9e-17 Alzheimer's disease; LUSC cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg26897989 chr16:1907736 C16orf73 -0.43 -6.74 -0.35 6.99e-11 Glomerular filtration rate in chronic kidney disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01494614 chr11:10562837 RNF141 -0.5 -5.98 -0.31 5.58e-9 Bipolar disorder and schizophrenia; LUSC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg11812906 chr14:75593930 NEK9 -0.64 -10.92 -0.51 6.02e-24 Height; LUSC cis rs17253792 0.822 rs78922774 chr14:56115302 T/A cg01858014 chr14:56050164 KTN1 -0.8 -6.58 -0.34 1.79e-10 Putamen volume; LUSC cis rs4951018 0.853 rs1573104 chr1:205636907 A/C cg14893161 chr1:205819251 PM20D1 -0.4 -5.84 -0.3 1.27e-8 Prostate-specific antigen levels; LUSC cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg07424592 chr7:64974309 NA 0.7 6.17 0.32 2e-9 Diabetic kidney disease; LUSC trans rs11039798 1.000 rs7942042 chr11:48520270 A/G cg15704280 chr7:45808275 SEPT13 0.71 6.65 0.34 1.21e-10 Axial length; LUSC cis rs2667011 0.512 rs12373732 chr2:160814453 A/C cg06573604 chr2:160760825 LY75 -0.46 -6.36 -0.33 6.68e-10 Bilirubin levels; LUSC cis rs7680126 0.500 rs4640669 chr4:10145733 A/G cg11266682 chr4:10021025 SLC2A9 0.42 5.66 0.3 3.28e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; LUSC cis rs16867335 1.000 rs35579320 chr2:181463612 T/C cg23363182 chr2:181467187 NA -0.46 -5.87 -0.31 1.05e-8 Survival in rectal cancer; LUSC cis rs8063761 0.640 rs4785760 chr16:90051438 G/A cg12064134 chr16:90016061 DEF8 0.37 5.81 0.3 1.48e-8 Squamous cell carcinoma; LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg04267008 chr7:1944627 MAD1L1 -0.54 -8.13 -0.41 8.55e-15 Bipolar disorder and schizophrenia; LUSC cis rs9831754 0.865 rs9842838 chr3:78387904 A/C cg06138941 chr3:78371609 NA -0.66 -8.99 -0.44 1.89e-17 Calcium levels; LUSC cis rs2777491 1.000 rs2730055 chr15:41735708 C/A cg18705301 chr15:41695430 NDUFAF1 -0.71 -12.99 -0.58 1.63e-31 Ulcerative colitis; LUSC cis rs1008375 1.000 rs1008374 chr4:17683219 G/A cg18681998 chr4:17616180 MED28 0.83 14.9 0.63 7.49e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10021803 chr11:74660260 XRRA1;SPCS2 0.44 6.13 0.32 2.46e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.8 0.3 1.51e-8 Intelligence (multi-trait analysis); LUSC trans rs12439619 0.883 rs62012045 chr15:82521707 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.55 -8.31 -0.41 2.5e-15 Intelligence (multi-trait analysis); LUSC cis rs1044826 0.642 rs6784684 chr3:139177634 T/C cg15131784 chr3:139108705 COPB2 0.4 6.48 0.33 3.24e-10 Obesity-related traits; LUSC cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg00852783 chr1:26633632 UBXN11 0.6 9.59 0.46 2.2e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs4332037 1.000 rs62442899 chr7:1948454 C/T cg23422044 chr7:1970798 MAD1L1 -0.66 -7.49 -0.38 6.29e-13 Bipolar disorder; LUSC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.08 15.72 0.65 4.61e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs1506636 1.000 rs2215553 chr7:123318478 G/T cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs3760982 0.585 rs11673490 chr19:44298885 C/A cg11993925 chr19:44307056 LYPD5 0.36 7.86 0.4 5.35e-14 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs9473147 0.516 rs9381575 chr6:47528764 C/G cg02130027 chr6:47444894 CD2AP 0.36 5.71 0.3 2.52e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7829975 0.846 rs1879957 chr8:8544808 T/C cg08975724 chr8:8085496 FLJ10661 -0.47 -7.16 -0.36 5.27e-12 Mood instability; LUSC cis rs2295359 0.892 rs11209004 chr1:67613932 G/A cg17031739 chr1:67600172 NA 0.44 6.87 0.35 3.22e-11 Psoriasis; LUSC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg20476274 chr7:133979776 SLC35B4 0.81 14.52 0.62 2.21e-37 Mean platelet volume; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.51 0.53 4.61e-26 Prudent dietary pattern; LUSC cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg06092702 chr1:163392909 NA -0.46 -7.78 -0.39 9.17e-14 Motion sickness; LUSC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg09238746 chr17:78121135 EIF4A3 -0.59 -8.77 -0.43 9.25e-17 Yeast infection; LUSC cis rs2652822 0.935 rs12594313 chr15:63436662 A/G cg02713581 chr15:63449717 RPS27L 0.42 6.53 0.34 2.39e-10 Metabolic traits; LUSC cis rs17407555 0.520 rs4292327 chr4:9943700 G/A cg00071950 chr4:10020882 SLC2A9 -0.52 -6.66 -0.34 1.11e-10 Schizophrenia (age at onset); LUSC cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg26647111 chr11:31128758 NA 0.43 6.11 0.32 2.77e-9 Bone mineral density (spine); LUSC cis rs9814567 1.000 rs9809619 chr3:134280948 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.0 -0.61 2.26e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1371867 0.817 rs7846076 chr8:101327629 A/G cg06002616 chr8:101225028 SPAG1 -0.44 -7.33 -0.37 1.73e-12 Atrioventricular conduction; LUSC cis rs11610422 0.953 rs12824490 chr12:31414490 C/T cg14306366 chr12:31406441 NA -0.55 -6.6 -0.34 1.58e-10 Coronary artery disease; LUSC trans rs62238980 0.522 rs117307005 chr22:32367511 C/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.03 -0.31 4.42e-9 Childhood ear infection; LUSC cis rs9420 0.961 rs7116341 chr11:57481155 G/A cg02958346 chr11:57425731 CLP1 -0.43 -6.28 -0.32 1.06e-9 Schizophrenia; LUSC cis rs9403521 1.000 rs116980222 chr6:143998987 C/T cg18240653 chr6:144019428 PHACTR2 -0.51 -6.16 -0.32 2.13e-9 Obesity-related traits; LUSC cis rs2742234 0.794 rs17153156 chr10:43704637 C/G cg15436174 chr10:43711423 RASGEF1A 0.34 6.23 0.32 1.41e-9 Hirschsprung disease; LUSC cis rs28647808 0.881 rs7852803 chr9:136245903 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.91 0.35 2.42e-11 Blood protein levels; LUSC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.55 0.38 4.2e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs73198271 1.000 rs73198279 chr8:8608504 A/G cg01851573 chr8:8652454 MFHAS1 0.58 8.0 0.4 2.04e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10779751 0.770 rs11121696 chr1:11238063 A/G cg08854313 chr1:11322531 MTOR -0.75 -10.93 -0.51 5.59e-24 Body mass index; LUSC cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg00376283 chr12:123451042 ABCB9 0.71 9.03 0.44 1.4e-17 Neutrophil percentage of white cells; LUSC cis rs6964587 0.869 rs405 chr7:91546327 G/C cg22709100 chr7:91322751 NA -0.4 -5.82 -0.3 1.37e-8 Breast cancer; LUSC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg00310523 chr12:86230176 RASSF9 0.47 8.69 0.43 1.7e-16 Major depressive disorder; LUSC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.96 0.44 2.3e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs9300255 0.602 rs1716168 chr12:123651966 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.36 6.0 0.31 5.26e-9 Neutrophil percentage of white cells; LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg03909863 chr11:638404 DRD4 -0.41 -6.19 -0.32 1.81e-9 Systemic lupus erythematosus; LUSC cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Bladder cancer; LUSC cis rs4786125 0.920 rs6500852 chr16:6896649 A/G cg03623568 chr16:6915990 A2BP1 -0.42 -6.99 -0.36 1.46e-11 Heart rate variability traits (SDNN); LUSC cis rs796364 0.662 rs11687313 chr2:201146399 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.55 -5.67 -0.3 3.13e-8 Schizophrenia; LUSC cis rs12618769 0.543 rs72819971 chr2:99034846 T/G cg10123293 chr2:99228465 UNC50 0.48 8.07 0.4 1.28e-14 Bipolar disorder; LUSC trans rs116175374 0.793 rs6727667 chr2:31431253 T/C cg15543616 chr12:5019024 KCNA1 -0.77 -6.01 -0.31 4.9e-9 Endometriosis; LUSC cis rs7569084 1.000 rs13385171 chr2:65661843 T/C cg08085232 chr2:65598271 SPRED2 0.39 6.02 0.31 4.47e-9 Sum eosinophil basophil counts; LUSC cis rs2901656 0.640 rs4916258 chr1:172413526 T/G cg03748243 chr1:172413542 C1orf105;PIGC 0.39 8.03 0.4 1.7e-14 Red cell distribution width;Platelet distribution width; LUSC cis rs9921338 0.961 rs11545336 chr16:11439496 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.62 -0.34 1.45e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg11062466 chr8:58055876 NA 0.7 8.6 0.43 3.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs67460515 0.531 rs13060601 chr3:160823159 G/A cg03342759 chr3:160939853 NMD3 -0.45 -6.18 -0.32 1.87e-9 Parkinson's disease; LUSC cis rs6500602 0.727 rs4786509 chr16:4568769 C/G cg08645402 chr16:4508243 NA -0.51 -8.68 -0.43 1.73e-16 Schizophrenia; LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 14.21 0.61 3.55e-36 Platelet count; LUSC cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg26384229 chr12:38710491 ALG10B 0.96 17.69 0.7 7.15e-50 Heart rate; LUSC cis rs765787 0.530 rs2433227 chr15:45517119 A/T cg25801113 chr15:45476975 SHF 0.34 7.0 0.36 1.37e-11 Uric acid levels; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg09763514 chr7:2298050 SNX8 0.38 6.27 0.32 1.11e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs7013285 0.514 rs7833269 chr8:107390396 C/T cg09394681 chr6:4482990 NA 0.41 5.96 0.31 6.5e-9 Paclitaxel disposition in epithelial ovarian cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01374398 chr3:47516975 SCAP 0.47 7.26 0.37 2.79e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1153858 0.723 rs4580098 chr15:45596909 T/A cg26924012 chr15:45694286 SPATA5L1 1.08 17.48 0.69 4.71e-49 Homoarginine levels; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.82 0.68 1.96e-46 Platelet count; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs634534 0.532 rs12794370 chr11:65770413 G/A cg17712092 chr4:129076599 LARP1B 0.69 10.36 0.49 5.21e-22 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9815354 0.812 rs4434125 chr3:42004681 A/G cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg04267008 chr7:1944627 MAD1L1 -0.52 -7.53 -0.38 4.64e-13 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24305835 chr1:17380585 SDHB 0.44 6.02 0.31 4.49e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs611744 0.647 rs2298603 chr8:109271426 C/T cg21045802 chr8:109455806 TTC35 0.41 6.53 0.34 2.4e-10 Dupuytren's disease; LUSC trans rs62103177 0.759 rs7227794 chr18:77610925 C/T cg14227996 chr4:17616232 MED28 0.79 8.14 0.41 7.78e-15 Opioid sensitivity; LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.96 0.51 4.51e-24 Menopause (age at onset); LUSC cis rs7512552 0.839 rs6703652 chr1:150465953 T/G cg15654264 chr1:150340011 RPRD2 0.63 10.31 0.49 8.08e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7113850 0.541 rs7948382 chr11:24246608 T/C ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6.23e-18 Bone fracture in osteoporosis; LUSC cis rs4851254 0.660 rs77023845 chr2:100712346 G/A cg07810366 chr2:100720526 AFF3 -0.45 -5.92 -0.31 7.9e-9 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.01 0.36 1.32e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7582180 0.629 rs11682557 chr2:100948008 C/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.58 -0.42 3.75e-16 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05170515 chr14:24899109 CBLN3;KHNYN 0.47 7.53 0.38 4.71e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs77972916 0.505 rs11899984 chr2:43578246 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -6.85 -0.35 3.6e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg08088566 chr11:430123 ANO9 0.67 7.35 0.37 1.56e-12 Body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19116747 chr5:149380656 HMGXB3;TIGD6 -0.52 -6.13 -0.32 2.43e-9 Bipolar disorder and schizophrenia; LUSC cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.93 -0.55 1.44e-27 Mean corpuscular volume; LUSC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -5.65 -0.3 3.53e-8 Calcium levels; LUSC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg06022373 chr22:39101656 GTPBP1 0.8 12.59 0.57 5.15e-30 Menopause (age at onset); LUSC cis rs11809207 1.000 rs55695238 chr1:26521931 C/G cg00147160 chr1:26503991 CNKSR1 0.42 6.96 0.36 1.8e-11 Height; LUSC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11890956 chr21:40555474 PSMG1 -0.72 -10.7 -0.51 3.58e-23 Menarche (age at onset); LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg07362569 chr17:61921086 SMARCD2 0.38 7.84 0.39 6.15e-14 Prudent dietary pattern; LUSC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.83 0.3 1.33e-8 Rheumatoid arthritis; LUSC cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg15744005 chr10:104629667 AS3MT -0.27 -5.71 -0.3 2.44e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9400467 0.528 rs456865 chr6:111632928 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.33 -6.14 -0.32 2.3e-9 Blood metabolite levels;Amino acid levels; LUSC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg12751644 chr20:60527061 NA -0.33 -6.04 -0.31 4.14e-9 Body mass index; LUSC cis rs240764 0.583 rs6905113 chr6:101209368 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.32e-9 Neuroticism; LUSC cis rs10276303 0.519 rs11768463 chr7:3396160 A/G cg21248987 chr7:3385318 SDK1 -0.39 -6.63 -0.34 1.33e-10 Dupuytren's disease; LUSC cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg08807101 chr21:30365312 RNF160 -0.52 -7.99 -0.4 2.28e-14 Dental caries; LUSC cis rs12594515 1.000 rs8031128 chr15:45988528 C/G cg01629716 chr15:45996671 NA 0.4 6.06 0.31 3.68e-9 Waist circumference;Weight; LUSC cis rs823156 1.000 rs823156 chr1:205764640 G/A cg11965913 chr1:205819406 PM20D1 0.48 5.93 0.31 7.47e-9 Parkinson's disease; LUSC cis rs9682041 0.627 rs3772172 chr3:170077713 C/T cg11886554 chr3:170076028 SKIL -0.68 -9.26 -0.45 2.64e-18 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg11584989 chr19:19387371 SF4 0.6 6.88 0.35 2.9100000000000002e-11 Bipolar disorder; LUSC cis rs7512552 0.839 rs832622 chr1:150392830 A/G cg15654264 chr1:150340011 RPRD2 0.61 10.04 0.48 6.57e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1018836 0.851 rs2023624 chr8:91618874 T/C cg16814680 chr8:91681699 NA -0.79 -13.33 -0.59 8.69e-33 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05301818 chr8:125385252 TMEM65 0.49 7.66 0.39 2.08e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8017423 0.904 rs11848894 chr14:90723660 C/A cg14092571 chr14:90743983 NA -0.36 -5.86 -0.31 1.11e-8 Mortality in heart failure; LUSC cis rs11166629 0.606 rs7006582 chr8:135595463 C/T cg27224718 chr8:135614730 ZFAT 0.54 7.72 0.39 1.37e-13 Smoking quantity; LUSC cis rs4363385 0.531 rs11205188 chr1:153053645 A/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.21 -0.32 1.61e-9 Inflammatory skin disease; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.59 0.34 1.76e-10 Menopause (age at onset); LUSC cis rs11039100 0.573 rs11038960 chr11:5780740 T/C cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.97 0.31 6.23e-9 Schizophrenia; LUSC cis rs2249625 0.545 rs2496495 chr6:72882414 G/A cg18830697 chr6:72922368 RIMS1 -0.37 -7.38 -0.37 1.25e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs2795502 1.000 rs3121323 chr10:43377166 A/G cg20628663 chr10:43360327 NA -0.76 -11.02 -0.52 2.71e-24 Blood protein levels; LUSC cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.1 -0.36 7.7e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs72949976 0.646 rs1441170 chr2:214033563 A/G cg08319019 chr2:214017104 IKZF2 -0.66 -10.59 -0.5 8.62e-23 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg10729496 chr3:10149963 C3orf24 0.55 7.23 0.37 3.39e-12 Alzheimer's disease; LUSC trans rs1325195 0.920 rs451088 chr1:179222840 A/C cg11624085 chr17:8464688 MYH10 -0.39 -6.43 -0.33 4.35e-10 IgE grass sensitization; LUSC cis rs778371 0.676 rs2293780 chr2:233635213 T/C cg08000102 chr2:233561755 GIGYF2 0.8 13.83 0.6 1.06e-34 Schizophrenia; LUSC cis rs4766566 0.568 rs11065857 chr12:111739500 A/G cg10833066 chr12:111807467 FAM109A 0.55 10.12 0.48 3.64e-21 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC trans rs561341 0.714 rs547473 chr17:30297560 T/G cg27661571 chr11:113659931 NA -0.62 -7.4 -0.38 1.08e-12 Hip circumference adjusted for BMI; LUSC cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.69 -0.3 2.73e-8 Bipolar disorder; LUSC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg03806693 chr22:41940476 POLR3H 0.99 13.97 0.61 3.1e-35 Vitiligo; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg22166914 chr1:53195759 ZYG11B 0.57 9.46 0.46 5.83e-19 Monocyte count; LUSC cis rs6906287 0.647 rs7766375 chr6:118918269 G/A cg21191810 chr6:118973309 C6orf204 0.33 6.01 0.31 4.83e-9 Electrocardiographic conduction measures; LUSC cis rs40363 1.000 rs37767 chr16:3514962 C/T cg05754148 chr16:3507555 NAT15 0.79 9.61 0.47 1.9e-19 Tuberculosis; LUSC cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs477692 0.699 rs528549 chr10:131381574 A/G cg05714579 chr10:131428358 MGMT 0.44 6.27 0.32 1.12e-9 Response to temozolomide; LUSC cis rs835154 0.845 rs835155 chr5:14875868 A/G cg14843632 chr5:14870594 ANKH -0.36 -6.88 -0.35 2.99e-11 Blood metabolite levels; LUSC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.27e-9 Life satisfaction; LUSC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg20203395 chr5:56204925 C5orf35 -0.78 -10.16 -0.49 2.61e-21 Type 2 diabetes; LUSC cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg22782873 chr19:19639568 YJEFN3 0.52 6.59 0.34 1.76e-10 Bipolar disorder; LUSC cis rs7666738 0.539 rs13150465 chr4:99094892 C/T cg05340658 chr4:99064831 C4orf37 -0.52 -5.96 -0.31 6.33e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.657 rs7664458 chr4:120371967 A/G cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs7267979 1.000 rs6050565 chr20:25347563 A/C cg08601574 chr20:25228251 PYGB -0.43 -6.76 -0.35 6.03e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs708547 0.533 rs3806746 chr4:57773330 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.47 -6.78 -0.35 5.54e-11 Response to bleomycin (chromatid breaks); LUSC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs11098499 0.863 rs10030660 chr4:120436704 G/A cg24375607 chr4:120327624 NA 0.76 11.09 0.52 1.51e-24 Corneal astigmatism; LUSC cis rs2439831 1.000 rs2444250 chr15:43785051 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg27535305 chr1:53392650 SCP2 -0.4 -7.57 -0.38 3.56e-13 Monocyte count; LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg11645453 chr3:52864694 ITIH4 0.36 8.35 0.42 1.84e-15 Bipolar disorder; LUSC cis rs7572644 0.766 rs10180107 chr2:28240525 C/T cg27432699 chr2:27873401 GPN1 0.53 6.72 0.35 7.63e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs3755132 0.929 rs4668951 chr2:15781195 A/G cg12888861 chr2:15731646 DDX1 0.52 7.31 0.37 1.95e-12 Wilms tumor; LUSC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.73 0.35 7.57e-11 Hip circumference adjusted for BMI; LUSC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg21285383 chr16:89894308 SPIRE2 0.31 6.64 0.34 1.24e-10 Vitiligo; LUSC cis rs244293 0.672 rs9901526 chr17:53012379 G/T cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -6.22 -0.32 1.51e-9 Menarche (age at onset); LUSC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg06212747 chr3:49208901 KLHDC8B 0.43 5.83 0.3 1.33e-8 Parkinson's disease; LUSC cis rs8062405 0.755 rs4787455 chr16:28589455 G/A cg16576597 chr16:28551801 NUPR1 0.34 6.87 0.35 3.15e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg19717773 chr7:2847554 GNA12 -0.36 -6.15 -0.32 2.18e-9 Height; LUSC cis rs4604732 0.631 rs4411161 chr1:247632374 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.77 0.35 5.85e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.33 0.33 7.88e-10 Coronary artery disease; LUSC cis rs57221529 0.766 rs72703075 chr5:592819 C/T cg09021430 chr5:549028 NA -0.57 -7.3 -0.37 2.07e-12 Lung disease severity in cystic fibrosis; LUSC cis rs9815354 0.597 rs60690674 chr3:41997811 G/C cg03022575 chr3:42003672 ULK4 0.81 8.53 0.42 5.02e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4285028 0.731 rs2877561 chr3:121712051 A/C cg20356878 chr3:121714668 ILDR1 0.47 6.57 0.34 1.95e-10 Multiple sclerosis; LUSC cis rs34779708 0.931 rs4934711 chr10:35360310 G/A cg04310649 chr10:35416472 CREM -0.42 -6.56 -0.34 2.01e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs4714291 0.832 rs2984431 chr6:39980900 T/A cg02267698 chr19:7991119 CTXN1 -0.53 -7.8 -0.39 7.87e-14 Strep throat; LUSC cis rs1008375 1.000 rs3815414 chr4:17606659 A/G cg04450456 chr4:17643702 FAM184B -0.37 -6.3 -0.33 9.46e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg08219700 chr8:58056026 NA 0.56 7.73 0.39 1.27e-13 Developmental language disorder (linguistic errors); LUSC trans rs2188420 0.688 rs1724278 chr7:106589230 T/C cg04262465 chr14:101405693 SNORD113-6 -0.4 -6.11 -0.32 2.75e-9 Interferon gamma levels; LUSC cis rs3096299 0.967 rs3102341 chr16:89450744 G/A cg06640241 chr16:89574553 SPG7 0.72 11.72 0.54 8.06e-27 Multiple myeloma (IgH translocation); LUSC cis rs13114435 0.606 rs17272827 chr4:183825774 C/G cg00486011 chr4:183851557 NA -0.3 -5.93 -0.31 7.57e-9 Obesity-related traits; LUSC trans rs477692 0.569 rs10764886 chr10:131310680 C/T cg25636556 chr4:3505128 NA 0.3 5.95 0.31 6.61e-9 Response to temozolomide; LUSC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs701145 0.617 rs9820619 chr3:154028294 G/T cg17054900 chr3:154042577 DHX36 0.48 6.37 0.33 6.34e-10 Coronary artery disease; LUSC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.19 -0.41 5.45e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs6543140 0.929 rs11465700 chr2:103057668 G/A cg09003973 chr2:102972529 NA 0.53 6.91 0.35 2.45e-11 Blood protein levels; LUSC cis rs1044826 0.642 rs295481 chr3:139228811 C/T cg00490450 chr3:139108681 COPB2 0.46 7.02 0.36 1.27e-11 Obesity-related traits; LUSC cis rs734999 0.549 rs3828154 chr1:2524943 G/A cg18854424 chr1:2615690 NA 0.51 10.34 0.49 6.36e-22 Ulcerative colitis; LUSC cis rs1577917 1.000 rs12201741 chr6:86602619 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.36 -0.33 6.77e-10 Response to antipsychotic treatment; LUSC trans rs656319 0.605 rs17747335 chr8:10003186 A/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.46 -0.38 7.39e-13 Myopia (pathological); LUSC cis rs7572644 0.640 rs11127126 chr2:28023284 C/T cg27432699 chr2:27873401 GPN1 0.57 7.4 0.38 1.15e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4555082 0.874 rs56263609 chr14:105756944 C/T cg13114125 chr14:105738426 BRF1 -0.94 -15.3 -0.64 2.1e-40 Mean platelet volume;Platelet distribution width; LUSC cis rs1577917 0.560 rs12193777 chr6:86246709 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 7.08 0.36 8.37e-12 Response to antipsychotic treatment; LUSC cis rs4589502 0.512 rs7183242 chr15:67096658 A/G cg12317470 chr15:67143691 NA 0.65 9.12 0.45 6.97e-18 Lung cancer (smoking interaction); LUSC cis rs6430585 0.583 rs3754689 chr2:136590746 C/T cg07169764 chr2:136633963 MCM6 1.06 15.67 0.65 7.43e-42 Corneal structure; LUSC cis rs11758351 0.866 rs11757394 chr6:26206694 G/C cg23601095 chr6:26197514 HIST1H3D 0.72 7.7 0.39 1.51e-13 Gout;Renal underexcretion gout; LUSC cis rs11608355 0.515 rs4766609 chr12:109973297 A/G cg05360138 chr12:110035743 NA 0.93 12.3 0.56 5.99e-29 Neuroticism; LUSC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.23 -0.32 1.42e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg11062466 chr8:58055876 NA 0.49 6.3 0.33 9.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg17178900 chr1:205818956 PM20D1 -0.44 -5.95 -0.31 6.81e-9 Parkinson's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19056515 chr10:105361785 SH3PXD2A 0.49 6.41 0.33 4.83e-10 Bipolar disorder and schizophrenia; LUSC cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg22467129 chr15:76604101 ETFA -0.42 -6.67 -0.34 1.04e-10 Blood metabolite levels; LUSC cis rs10751667 1.000 rs7396366 chr11:986185 C/A ch.11.42038R chr11:967971 AP2A2 0.54 7.96 0.4 2.73e-14 Alzheimer's disease (late onset); LUSC cis rs7584330 0.518 rs74003106 chr2:238447004 A/G cg14458575 chr2:238380390 NA 0.58 6.82 0.35 4.36e-11 Prostate cancer; LUSC cis rs16866061 1.000 rs2047134 chr2:225347713 A/C cg12698349 chr2:225449008 CUL3 0.86 13.53 0.59 1.51e-33 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg16423285 chr20:60520624 NA -0.47 -5.83 -0.3 1.3e-8 Body mass index; LUSC cis rs9788682 0.655 rs578776 chr15:78888400 G/A cg24631222 chr15:78858424 CHRNA5 0.61 9.17 0.45 5.03e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1050846 0.564 rs1050863 chr16:87440895 C/T cg27585878 chr16:87386489 FBXO31 -0.41 -6.81 -0.35 4.42e-11 Neuroticism; LUSC cis rs2286503 0.839 rs2270108 chr7:22862131 A/C cg11367502 chr7:22862612 TOMM7 0.46 6.22 0.32 1.51e-9 Fibrinogen; LUSC cis rs9287719 0.967 rs759402 chr2:10729554 A/T cg00105475 chr2:10696890 NA 0.37 6.09 0.32 3.03e-9 Prostate cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21657490 chr7:150815391 AGAP3 0.49 6.13 0.32 2.5e-9 Bipolar disorder and schizophrenia; LUSC cis rs7267979 0.934 rs2500399 chr20:25354694 T/G cg03522245 chr20:25566470 NINL -0.35 -5.78 -0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg20283391 chr11:68216788 NA 0.51 7.38 0.37 1.3e-12 Total body bone mineral density; LUSC cis rs113835537 0.529 rs11227525 chr11:66308065 T/G cg24851651 chr11:66362959 CCS 0.53 7.77 0.39 1e-13 Airway imaging phenotypes; LUSC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg25019033 chr10:957182 NA -0.51 -6.35 -0.33 7.22e-10 Eosinophil percentage of granulocytes; LUSC cis rs4363385 0.719 rs6664411 chr1:152932857 T/C cg00922841 chr1:152955080 SPRR1A -0.41 -6.72 -0.34 8.01e-11 Inflammatory skin disease; LUSC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.35 -5.71 -0.3 2.45e-8 Total body bone mineral density; LUSC trans rs2262909 0.962 rs73019889 chr19:22277826 C/G cg17074339 chr11:11642133 GALNTL4 0.44 6.76 0.35 6.13e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs1371867 0.846 rs1788167 chr8:101319996 C/T cg06002616 chr8:101225028 SPAG1 -0.41 -6.9 -0.35 2.62e-11 Atrioventricular conduction; LUSC cis rs61931739 0.534 rs4931772 chr12:34044590 G/A cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.05e-15 Morning vs. evening chronotype; LUSC cis rs2463822 0.669 rs72919484 chr11:62043430 T/C cg06239285 chr11:62104954 ASRGL1 -0.75 -7.26 -0.37 2.74e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.82 12.84 0.57 6.13e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs950027 0.595 rs2486288 chr15:45712339 T/C cg21132104 chr15:45694354 SPATA5L1 0.4 5.8 0.3 1.54e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs7666738 0.716 rs11097615 chr4:99092773 T/C cg03676636 chr4:99064102 C4orf37 0.29 6.11 0.32 2.76e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08704250 chr15:31115839 NA -0.41 -6.3 -0.33 9.64e-10 Huntington's disease progression; LUSC cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg24812749 chr6:127587940 RNF146 0.91 13.7 0.6 3.3e-34 Breast cancer; LUSC cis rs4253772 0.678 rs1055659 chr22:46638298 C/T cg09491104 chr22:46646882 C22orf40 -0.56 -7.72 -0.39 1.33e-13 LDL cholesterol;Cholesterol, total; LUSC trans rs941408 0.515 rs1005556 chr19:2778543 G/T cg19676328 chr12:49525230 TUBA1B -0.52 -7.48 -0.38 6.71e-13 Total cholesterol levels; LUSC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.36 -5.98 -0.31 5.87e-9 Personality dimensions; LUSC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg17143192 chr8:8559678 CLDN23 -0.59 -8.79 -0.43 7.83e-17 Obesity-related traits; LUSC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs2486288 0.656 rs7166580 chr15:45571209 C/G cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.42e-10 Glomerular filtration rate; LUSC cis rs1375194 0.606 rs935625 chr2:33811516 C/G cg04131969 chr2:33951647 MYADML -0.62 -8.67 -0.43 1.93e-16 Response to antidepressants in depression; LUSC trans rs6076960 0.629 rs6054031 chr20:6233657 C/G cg21095983 chr6:86352623 SYNCRIP 0.5 7.75 0.39 1.08e-13 Smooth-surface caries; LUSC cis rs6087990 0.899 rs4911262 chr20:31393352 G/A cg13636640 chr20:31349939 DNMT3B 0.97 21.38 0.76 1.61e-64 Ulcerative colitis; LUSC cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.62 -0.34 1.44e-10 Monocyte percentage of white cells; LUSC cis rs11229555 0.645 rs11229460 chr11:58208343 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs8114671 0.562 rs8116657 chr20:33476474 C/G cg24642439 chr20:33292090 TP53INP2 0.45 6.45 0.33 4.04e-10 Height; LUSC trans rs62103177 0.525 rs10438902 chr18:77745640 A/G cg05926928 chr17:57297772 GDPD1 -0.91 -10.29 -0.49 9.37e-22 Opioid sensitivity; LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg18404041 chr3:52824283 ITIH1 0.63 12.69 0.57 2.26e-30 Bipolar disorder; LUSC cis rs727505 0.954 rs2170352 chr7:124605584 G/A cg23710748 chr7:124431027 NA -0.37 -6.57 -0.34 1.9e-10 Lewy body disease; LUSC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg05253716 chr12:129299332 SLC15A4;MGC16384 -0.45 -6.66 -0.34 1.12e-10 Systemic lupus erythematosus; LUSC cis rs1691799 0.899 rs1168303 chr12:66738586 A/G cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.45e-31 White blood cell count (basophil); LUSC cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg03146154 chr1:46216737 IPP -0.51 -7.22 -0.37 3.47e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.1 0.36 7.61e-12 Cognitive ability; LUSC cis rs62027291 0.846 rs56307118 chr15:77284742 G/C cg26408565 chr15:76604113 ETFA 0.49 6.22 0.32 1.5e-9 Plateletcrit; LUSC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg08270630 chr22:50330655 NA 0.37 5.66 0.3 3.2e-8 Schizophrenia; LUSC cis rs9486715 0.825 rs211158 chr6:97022938 C/G cg06623918 chr6:96969491 KIAA0776 -0.92 -17.08 -0.68 1.83e-47 Headache; LUSC trans rs3960554 0.808 rs59882870 chr7:75638421 G/A cg19862616 chr7:65841803 NCRNA00174 0.8 9.01 0.44 1.59e-17 Eotaxin levels; LUSC trans rs62238980 0.614 rs74450300 chr22:32403780 C/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg16339924 chr4:17578868 LAP3 0.51 7.78 0.39 9.33e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2580764 0.515 rs7570629 chr2:55255935 A/T cg09592903 chr2:55203963 RTN4 -0.5 -10.27 -0.49 1.14e-21 Mean platelet volume; LUSC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg09796270 chr17:17721594 SREBF1 0.42 7.47 0.38 7.26e-13 Total body bone mineral density; LUSC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg19824325 chr16:58548873 SETD6 0.93 9.11 0.45 7.52e-18 Schizophrenia; LUSC trans rs7769051 1.000 rs5006218 chr6:133126220 T/G cg27275811 chr11:74457193 NA -0.64 -6.16 -0.32 2.07e-9 Type 2 diabetes nephropathy; LUSC cis rs6701037 0.748 rs10912901 chr1:175138602 G/A cg17845761 chr1:175162550 KIAA0040 -0.32 -6.18 -0.32 1.81e-9 Alcohol dependence; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg12204362 chr12:98910117 TMPO;LOC100128191 0.48 6.62 0.34 1.43e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg13057898 chr1:3703894 LRRC47 0.48 8.74 0.43 1.17e-16 Red cell distribution width; LUSC cis rs9653442 0.593 rs6737502 chr2:100862903 C/T cg22139774 chr2:100720529 AFF3 -0.39 -6.45 -0.33 3.95e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs926938 0.505 rs360629 chr1:115414733 A/G cg12756093 chr1:115239321 AMPD1 0.45 6.53 0.34 2.45e-10 Autism; LUSC cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg01579765 chr21:45077557 HSF2BP 0.53 10.88 0.51 8.64e-24 Mean corpuscular volume; LUSC cis rs7829975 0.572 rs7005000 chr8:8796602 A/G cg08975724 chr8:8085496 FLJ10661 -0.45 -7.04 -0.36 1.11e-11 Mood instability; LUSC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 7.55 0.38 4.28e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg21782813 chr7:2030301 MAD1L1 0.37 6.1 0.32 3e-9 Bipolar disorder and schizophrenia; LUSC cis rs6426558 0.502 rs2813970 chr1:227410637 C/T cg10327440 chr1:227177885 CDC42BPA 0.55 7.35 0.37 1.54e-12 Neutrophil percentage of white cells; LUSC cis rs71636778 0.543 rs34409791 chr1:27245363 A/G cg12203394 chr1:27248618 NUDC 0.53 5.65 0.3 3.47e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 9.16 0.45 5.28e-18 Hip circumference adjusted for BMI; LUSC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg24585782 chr17:78113791 EIF4A3 -0.53 -7.88 -0.4 4.79e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs3772130 0.603 rs10470410 chr3:121434977 G/T cg20356878 chr3:121714668 ILDR1 0.51 8.14 0.41 7.72e-15 Cognitive performance; LUSC cis rs2067615 0.524 rs1882543 chr12:107067160 A/G cg19260189 chr12:106995001 RFX4 -0.24 -6.11 -0.32 2.7e-9 Heart rate; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg22868518 chr11:507468 RNH1 0.59 5.81 0.3 1.44e-8 Body mass index; LUSC cis rs9322193 0.504 rs7771014 chr6:150205446 T/A cg09699651 chr6:150184138 LRP11 0.44 7.06 0.36 9.92e-12 Lung cancer; LUSC trans rs4295623 0.585 rs13259242 chr8:11593033 T/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.22 -0.41 4.42e-15 Morning vs. evening chronotype; LUSC cis rs16910800 1.000 rs2468649 chr11:23200963 T/C cg20040320 chr11:23191996 NA 0.44 6.47 0.33 3.59e-10 Cancer; LUSC cis rs611744 0.647 rs1448150 chr8:109276161 T/C cg21045802 chr8:109455806 TTC35 0.43 6.67 0.34 1.06e-10 Dupuytren's disease; LUSC cis rs1799949 0.602 rs8176199 chr17:41230524 T/G cg05368731 chr17:41323189 NBR1 0.92 13.01 0.58 1.44e-31 Menopause (age at onset); LUSC cis rs2204008 0.807 rs10880234 chr12:38318353 C/T cg13010199 chr12:38710504 ALG10B 0.65 9.76 0.47 5.95e-20 Bladder cancer; LUSC cis rs709400 0.691 rs12888077 chr14:103872553 G/T cg12935359 chr14:103987150 CKB 0.51 8.08 0.4 1.17e-14 Body mass index; LUSC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg09365446 chr1:150670422 GOLPH3L -0.43 -6.42 -0.33 4.69e-10 Tonsillectomy; LUSC trans rs561341 1.000 rs510264 chr17:30323414 A/G cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg26395211 chr5:140044315 WDR55 0.45 6.98 0.36 1.6e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9660992 0.710 rs1172136 chr1:205247097 T/G cg00857998 chr1:205179979 DSTYK 0.61 9.17 0.45 4.95e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7215564 0.643 rs59992540 chr17:78658265 G/A cg23238734 chr17:78661607 RPTOR 0.48 6.16 0.32 2.07e-9 Myopia (pathological); LUSC cis rs7712401 0.601 rs371604 chr5:122318432 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs11685299 1 rs11685299 chr2:225391296 C/A cg12698349 chr2:225449008 CUL3 0.84 13.4 0.59 4.48e-33 Schizophrenia; LUSC cis rs17401966 0.540 rs6541094 chr1:10467074 G/A cg19773385 chr1:10388646 KIF1B -0.42 -7.3 -0.37 2.11e-12 Hepatocellular carcinoma; LUSC cis rs7829975 0.686 rs907180 chr8:8702827 A/G cg15556689 chr8:8085844 FLJ10661 0.61 9.74 0.47 6.87e-20 Mood instability; LUSC trans rs9291683 0.595 rs13145442 chr4:10037261 C/A cg26043149 chr18:55253948 FECH 0.49 7.22 0.37 3.43e-12 Bone mineral density; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg00431813 chr7:1051703 C7orf50 0.38 6.08 0.32 3.33e-9 Longevity;Endometriosis; LUSC cis rs7605827 0.930 rs3732004 chr2:15713783 C/T cg19274914 chr2:15703543 NA 0.46 8.9 0.44 3.68e-17 Educational attainment (years of education); LUSC cis rs9300255 0.602 rs1727306 chr12:123665695 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.13 -0.32 2.47e-9 Neutrophil percentage of white cells; LUSC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg00149659 chr3:10157352 C3orf10 -0.64 -9.53 -0.46 3.24e-19 Alzheimer's disease; LUSC trans rs12439619 0.693 rs17269819 chr15:82467001 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.44 -6.22 -0.32 1.46e-9 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg27266027 chr21:40555129 PSMG1 0.43 6.19 0.32 1.76e-9 Cognitive function; LUSC cis rs4851254 0.517 rs13020141 chr2:100653842 G/A cg22139774 chr2:100720529 AFF3 -0.45 -5.91 -0.31 8.36e-9 Intelligence (multi-trait analysis); LUSC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg06656553 chr16:89960601 TCF25 -0.64 -5.66 -0.3 3.2e-8 Skin colour saturation; LUSC cis rs7561273 0.722 rs12713161 chr2:24280682 T/C cg06627628 chr2:24431161 ITSN2 -0.4 -5.72 -0.3 2.4e-8 Quantitative traits; LUSC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs11677370 0.603 rs10171309 chr2:3851690 C/T cg17052675 chr2:3827356 NA -0.62 -10.02 -0.48 7.61e-21 Type 2 diabetes; LUSC cis rs7432375 0.610 rs28458819 chr3:136522314 A/G cg21827317 chr3:136751795 NA 0.32 5.67 0.3 3.03e-8 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs12530845 0.945 rs76298187 chr7:135334534 A/G cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg26513180 chr16:89883248 FANCA -0.9 -17.47 -0.69 5.26e-49 Vitiligo; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25347033 chr10:105881828 C10orf78 -0.44 -6.44 -0.33 4.2e-10 Electrocardiographic conduction measures; LUSC trans rs17076896 0.881 rs36213076 chr13:19757647 C/T cg01891818 chr17:73008509 ICT1 0.5 6.17 0.32 1.97e-9 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs979233 0.502 rs276272 chr5:42075482 C/G cg07010552 chr17:7358735 CHRNB1 -0.41 -6.09 -0.32 3.15e-9 Systemic lupus erythematosus; LUSC cis rs765787 0.530 rs4331289 chr15:45515338 C/T cg24006582 chr15:45444508 DUOX1 -0.62 -9.1 -0.45 8.07e-18 Uric acid levels; LUSC cis rs11648785 0.661 rs870856 chr16:90089463 C/G cg05270750 chr16:90143788 PRDM7 0.44 5.97 0.31 5.96e-9 Tanning; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg15790184 chr11:494944 RNH1 0.58 6.16 0.32 2.09e-9 Body mass index; LUSC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg06022373 chr22:39101656 GTPBP1 0.84 14.01 0.61 2.07e-35 Menopause (age at onset); LUSC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg10560079 chr2:191398806 TMEM194B 0.51 8.31 0.41 2.48e-15 Pulse pressure; LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.11 16.38 0.67 1.12e-44 Gut microbiome composition (summer); LUSC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.07 0.48 5.28e-21 Electroencephalogram traits; LUSC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg26597838 chr10:835615 NA -0.48 -6.42 -0.33 4.73e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg00255919 chr5:131827918 IRF1 0.43 8.24 0.41 3.88e-15 Asthma (sex interaction); LUSC cis rs1448094 0.872 rs12322940 chr12:86406708 G/C cg00310523 chr12:86230176 RASSF9 0.35 6.28 0.33 1.03e-9 Major depressive disorder; LUSC cis rs7246657 0.943 rs7259968 chr19:37811854 T/C cg23950597 chr19:37808831 NA -0.65 -7.91 -0.4 3.76e-14 Coronary artery calcification; LUSC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg10295955 chr4:187884368 NA -1.07 -24.21 -0.8 1.77e-75 Lobe attachment (rater-scored or self-reported); LUSC cis rs4555082 0.834 rs4412909 chr14:105759226 T/C cg10792982 chr14:105748885 BRF1 0.46 8.21 0.41 4.9e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg16049864 chr8:95962084 TP53INP1 -0.66 -12.3 -0.56 6.3e-29 Type 2 diabetes; LUSC cis rs9326248 0.539 rs10892058 chr11:116876621 C/T cg11861562 chr11:117069780 TAGLN 0.32 6.22 0.32 1.45e-9 Blood protein levels; LUSC trans rs2898290 0.622 rs1382567 chr8:11350899 T/C cg15556689 chr8:8085844 FLJ10661 -0.54 -8.48 -0.42 7.6e-16 Systolic blood pressure; LUSC cis rs7528419 1.000 rs646776 chr1:109818530 C/T cg00908766 chr1:109817496 CELSR2 0.71 11.43 0.53 9.06e-26 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; LUSC cis rs1729951 0.575 rs361243 chr3:136697786 C/T cg12473912 chr3:136751656 NA 0.39 6.82 0.35 4.16e-11 Neuroticism; LUSC cis rs11867934 0.773 rs2090018 chr17:17020967 A/G cg26176665 chr17:16994978 MPRIP -0.4 -5.68 -0.3 2.9e-8 Diabetic retinopathy; LUSC cis rs950169 0.800 rs4842847 chr15:84931199 G/A cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.05e-14 Schizophrenia; LUSC cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.05 -0.44 1.22e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg04287289 chr16:89883240 FANCA -0.44 -6.33 -0.33 7.69e-10 Vitiligo; LUSC cis rs13064411 0.627 rs28536176 chr3:113143625 T/C cg18753928 chr3:113234510 CCDC52 -0.5 -7.53 -0.38 4.89e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg27279351 chr12:120934652 DYNLL1 0.6 8.0 0.4 2.09e-14 High light scatter reticulocyte count; LUSC trans rs2243480 0.764 rs2460423 chr7:65601216 A/T cg10756647 chr7:56101905 PSPH 0.89 8.89 0.44 3.83e-17 Diabetic kidney disease; LUSC trans rs72674100 1.000 rs28804793 chr4:97962269 T/C cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1577917 0.876 rs12212808 chr6:86533972 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg23758822 chr17:41437982 NA 1.0 15.73 0.65 4.13e-42 Menopause (age at onset); LUSC cis rs2742417 0.609 rs2673066 chr3:45771200 C/T cg04837898 chr3:45731254 SACM1L -0.44 -7.06 -0.36 9.42e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2067615 0.579 rs6539283 chr12:107222989 C/T cg15890332 chr12:107067104 RFX4 0.35 6.21 0.32 1.55e-9 Heart rate; LUSC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg08847533 chr14:75593920 NEK9 -0.8 -13.76 -0.6 1.92e-34 Height; LUSC cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg13256891 chr4:100009986 ADH5 -0.45 -6.23 -0.32 1.43e-9 Alcohol dependence; LUSC trans rs7647973 0.710 rs1532204 chr3:49609477 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 6.98e-13 Menarche (age at onset); LUSC cis rs6690583 0.623 rs12047435 chr1:85452927 T/G cg11262906 chr1:85462892 MCOLN2 0.68 6.58 0.34 1.82e-10 Serum sulfate level; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg19318889 chr4:1322082 MAEA 0.78 14.72 0.63 3.88e-38 Longevity; LUSC cis rs4478858 0.684 rs11579845 chr1:31736248 A/G cg00250761 chr1:31883323 NA -0.32 -7.77 -0.39 9.54e-14 Alcohol dependence; LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg02018176 chr4:1364513 KIAA1530 0.51 8.65 0.43 2.19e-16 Obesity-related traits; LUSC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg03264133 chr6:25882463 NA -0.44 -7.61 -0.38 2.87e-13 Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.65 0.3 3.4e-8 Breast cancer; LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.5 6.07 0.32 3.48e-9 Renal function-related traits (BUN); LUSC cis rs2354432 0.556 rs2353977 chr1:146839637 G/T cg25205988 chr1:146714368 CHD1L 0.85 7.61 0.38 2.86e-13 Mitochondrial DNA levels; LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg26338869 chr17:61819248 STRADA 0.4 5.75 0.3 1.99e-8 Prudent dietary pattern; LUSC cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg23093090 chr10:104574429 C10orf26 -0.43 -7.67 -0.39 1.86e-13 Arsenic metabolism; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg08888203 chr3:10149979 C3orf24 0.59 8.1 0.41 1.08e-14 Alzheimer's disease; LUSC cis rs1461503 0.900 rs7110039 chr11:122834001 C/T cg27398637 chr11:122830231 C11orf63 0.44 6.97 0.36 1.66e-11 Menarche (age at onset); LUSC cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg11102782 chr19:18549136 ISYNA1 -0.34 -6.53 -0.34 2.39e-10 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11564042 chr3:150479915 SIAH2 0.44 6.71 0.34 8.47e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6543140 0.964 rs6543143 chr2:103085420 A/C cg09003973 chr2:102972529 NA 0.53 6.75 0.35 6.5500000000000006e-11 Blood protein levels; LUSC cis rs11122272 0.701 rs1009227 chr1:231480507 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.07 -0.48 5.45e-21 Hemoglobin concentration; LUSC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg24503407 chr1:205819492 PM20D1 0.42 5.73 0.3 2.23e-8 Parkinson's disease; LUSC cis rs7267979 0.966 rs3827014 chr20:25371559 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.55 -0.34 2.15e-10 Electroencephalogram traits; LUSC trans rs4332037 0.707 rs73046323 chr7:1882795 G/A cg11693508 chr17:37793320 STARD3 0.53 6.48 0.33 3.31e-10 Bipolar disorder; LUSC cis rs7804356 0.861 rs10262414 chr7:26854266 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs1395 0.710 rs72817533 chr2:27482612 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.26 0.37 2.74e-12 Blood metabolite levels; LUSC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.4 -0.38 1.09e-12 Developmental language disorder (linguistic errors); LUSC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg20933634 chr6:27740509 NA 0.42 5.89 0.31 9.49e-9 Parkinson's disease; LUSC trans rs11039798 0.588 rs6485869 chr11:48576903 G/T cg15704280 chr7:45808275 SEPT13 0.63 7.17 0.37 5e-12 Axial length; LUSC trans rs9467711 0.790 rs13195402 chr6:26463575 G/T cg06606381 chr12:133084897 FBRSL1 -0.76 -6.36 -0.33 6.82e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs617219 0.853 rs7448481 chr5:78507410 C/T cg24856658 chr5:78533917 JMY -0.3 -5.86 -0.31 1.13e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg15691649 chr6:25882328 NA -0.39 -6.37 -0.33 6.13e-10 Blood metabolite levels; LUSC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.58 0.38 3.45e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs9388451 0.874 rs9398787 chr6:126090608 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.6 -9.54 -0.46 3.03e-19 Brugada syndrome; LUSC cis rs9341808 0.519 rs3805872 chr6:81035102 G/A cg08355045 chr6:80787529 NA -0.44 -7.51 -0.38 5.61e-13 Sitting height ratio; LUSC cis rs240764 0.817 rs239249 chr6:101087081 G/A cg09795085 chr6:101329169 ASCC3 0.41 5.94 0.31 7.1e-9 Neuroticism; LUSC cis rs35883536 0.647 rs12023028 chr1:101042717 C/T cg06223162 chr1:101003688 GPR88 -0.48 -9.03 -0.44 1.4e-17 Monocyte count; LUSC cis rs4363385 0.740 rs1697428 chr1:153015761 C/A cg24667326 chr1:152973720 SPRR3 -0.35 -5.8 -0.3 1.54e-8 Inflammatory skin disease; LUSC cis rs12545109 0.836 rs2196586 chr8:57347126 C/T cg09654669 chr8:57350985 NA 0.57 7.64 0.39 2.39e-13 Obesity-related traits; LUSC cis rs1395 1.000 rs6717980 chr2:27452784 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.38 6.34 0.33 7.53e-10 Blood metabolite levels; LUSC cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.54 -8.1 -0.41 1.01e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg10802521 chr3:52805072 NEK4 -0.55 -8.84 -0.44 5.51e-17 Bipolar disorder; LUSC cis rs9341808 0.718 rs35447745 chr6:80816748 T/C cg08355045 chr6:80787529 NA 0.56 9.6 0.46 2.04e-19 Sitting height ratio; LUSC cis rs7246967 0.611 rs4933019 chr19:22831986 A/G cg23217946 chr19:22817039 ZNF492 0.45 6.04 0.31 4.09e-9 Bronchopulmonary dysplasia; LUSC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.93 0.4 3.22e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs897080 0.515 rs786401 chr2:44712069 G/A cg00619915 chr2:44497795 NA -0.44 -6.35 -0.33 7.09e-10 Height; LUSC cis rs11758351 0.925 rs10452600 chr6:26192502 C/A cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs12579753 0.917 rs12366599 chr12:82212112 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -5.94 -0.31 7.26e-9 Resting heart rate; LUSC cis rs60843830 0.550 rs300751 chr2:209063 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.38 5.89 0.31 9.33e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs11971779 0.553 rs11973507 chr7:139099461 A/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.97 -0.36 1.73e-11 Lung cancer; LUSC cis rs9653442 0.545 rs1821827 chr2:100764717 T/C cg07810366 chr2:100720526 AFF3 -0.45 -7.68 -0.39 1.83e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs909002 0.849 rs6663012 chr1:32091779 T/G cg01639898 chr1:32083012 HCRTR1 0.28 6.61 0.34 1.48e-10 Intelligence (multi-trait analysis); LUSC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg16386425 chr10:429943 DIP2C -0.46 -7.36 -0.37 1.42e-12 Psychosis in Alzheimer's disease; LUSC cis rs9392556 0.829 rs612022 chr6:4126916 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -6.43 -0.33 4.52e-10 Blood metabolite levels; LUSC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg11366901 chr6:160182831 ACAT2 0.94 12.48 0.56 1.37e-29 Age-related macular degeneration (geographic atrophy); LUSC trans rs11098499 0.909 rs10002083 chr4:120311152 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.13 0.55 2.54e-28 Cognitive test performance; LUSC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11890956 chr21:40555474 PSMG1 -0.73 -11.01 -0.52 2.85e-24 Menarche (age at onset); LUSC cis rs7617480 0.544 rs6442129 chr3:48735256 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.6 9.18 0.45 4.46e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs10191773 0.589 rs11691239 chr2:112950600 A/C cg24977338 chr2:113188963 RGPD8;RGPD5 0.5 5.76 0.3 1.86e-8 Yeast infection; LUSC cis rs7216064 0.953 rs4791046 chr17:65851973 G/A cg12091567 chr17:66097778 LOC651250 -0.7 -8.99 -0.44 1.81e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs11098499 0.575 rs907205 chr4:120238664 G/C cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.23e-28 Corneal astigmatism; LUSC cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg24692254 chr21:30365293 RNF160 -0.93 -18.94 -0.72 7.35e-55 Dental caries; LUSC cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg03146154 chr1:46216737 IPP 0.51 7.41 0.38 1.03e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg18641478 chr19:17970431 RPL18AP3;RPL18A -0.4 -6.03 -0.31 4.45e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.83 9.63 0.47 1.56e-19 Mean platelet volume; LUSC trans rs2700987 0.692 rs1882079 chr7:37391266 C/T cg26076750 chr5:98105150 RGMB -0.36 -6.61 -0.34 1.5e-10 Psoriasis vulgaris;Psoriasis; LUSC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg15649852 chr7:65879115 NA -0.42 -5.83 -0.3 1.3e-8 Aortic root size; LUSC cis rs7107174 1.000 rs2292572 chr11:78052864 G/T cg02023728 chr11:77925099 USP35 0.46 7.01 0.36 1.29e-11 Testicular germ cell tumor; LUSC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg16339924 chr4:17578868 LAP3 0.54 8.27 0.41 3.22e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1163251 0.837 rs611365 chr1:120242571 C/T cg19096424 chr1:120255104 PHGDH 0.44 6.03 0.31 4.29e-9 Blood metabolite levels; LUSC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs10743315 0.643 rs17505214 chr12:19307139 A/G cg02471346 chr12:19282374 PLEKHA5 0.79 6.52 0.34 2.53e-10 Gut microbiota (bacterial taxa); LUSC cis rs12681287 0.640 rs13256765 chr8:87457833 C/T cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.2 0.49 1.94e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg05347473 chr6:146136440 FBXO30 0.57 9.88 0.48 2.24e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7089973 0.604 rs2420069 chr10:116605103 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4072705 0.967 rs4076333 chr9:127385609 A/G cg13476313 chr9:127244764 NR5A1 0.3 5.84 0.3 1.21e-8 Menarche (age at onset); LUSC cis rs17102423 0.623 rs2093989 chr14:65553939 C/T cg11161011 chr14:65562177 MAX -0.74 -11.07 -0.52 1.79e-24 Obesity-related traits; LUSC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg24920358 chr1:40204285 PPIE 0.59 10.15 0.49 2.79e-21 Blood protein levels; LUSC cis rs2651899 0.902 rs1624023 chr1:3079337 C/T cg22674798 chr1:3096360 PRDM16 0.31 7.07 0.36 8.95e-12 Migraine; LUSC trans rs11098499 0.909 rs35111518 chr4:120440682 A/G cg25214090 chr10:38739885 LOC399744 0.52 7.54 0.38 4.52e-13 Corneal astigmatism; LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.99 0.4 2.18e-14 Prudent dietary pattern; LUSC cis rs12545109 0.800 rs2118261 chr8:57393286 A/G cg09654669 chr8:57350985 NA 0.51 6.78 0.35 5.58e-11 Obesity-related traits; LUSC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg15534755 chr11:117069859 TAGLN -0.35 -6.13 -0.32 2.46e-9 Blood protein levels; LUSC cis rs6495367 1.000 rs1007366 chr15:79379541 G/A cg17916960 chr15:79447300 NA 0.36 6.64 0.34 1.27e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg02569458 chr12:86230093 RASSF9 0.52 8.61 0.43 2.94e-16 Major depressive disorder; LUSC cis rs5758511 0.573 rs5996074 chr22:42236337 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.39 -7.42 -0.38 9.64e-13 Birth weight; LUSC cis rs870825 0.616 rs6552806 chr4:185638231 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC cis rs868036 0.681 rs4548812 chr15:68060552 G/A cg24579218 chr15:68104479 NA -0.36 -6.21 -0.32 1.55e-9 Restless legs syndrome; LUSC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11644478 chr21:40555479 PSMG1 0.93 16.81 0.68 2.16e-46 Cognitive function; LUSC cis rs17540621 1.000 rs71423932 chr2:47202613 G/C cg23978866 chr2:47230407 TTC7A -0.71 -5.7 -0.3 2.7e-8 Response to statin therapy; LUSC cis rs6961069 0.621 rs34801616 chr7:80240512 T/C cg04458919 chr7:80252533 CD36 -0.42 -7.29 -0.37 2.23e-12 Platelet count; LUSC cis rs72781680 1.000 rs17762102 chr2:24085606 A/G cg20701182 chr2:24300061 SF3B14 0.56 6.05 0.31 3.84e-9 Lymphocyte counts; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.53 -9.27 -0.45 2.33e-18 Bipolar disorder; LUSC cis rs6669072 0.565 rs992544 chr1:91278411 A/T cg08895590 chr1:91227319 NA -0.26 -5.67 -0.3 3.03e-8 Cognitive function; LUSC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg08132940 chr7:1081526 C7orf50 -0.49 -6.17 -0.32 2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs709400 0.663 rs9671911 chr14:103967343 T/C cg10523860 chr14:103875565 MARK3 -0.36 -5.8 -0.3 1.54e-8 Body mass index; LUSC cis rs10904908 0.931 rs7903137 chr10:17259567 C/T cg01003015 chr10:17271136 VIM -0.43 -6.2 -0.32 1.66e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg02503808 chr4:7069936 GRPEL1 1.04 14.7 0.63 4.56e-38 Monocyte percentage of white cells; LUSC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs11625487 0.609 rs74063206 chr14:77981045 C/T cg16049707 chr14:77965284 ISM2 -0.59 -6.19 -0.32 1.81e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg02951883 chr7:2050386 MAD1L1 -0.59 -11.17 -0.52 8.06e-25 Bipolar disorder and schizophrenia; LUSC cis rs10028773 0.568 rs6838457 chr4:120267367 A/G cg24375607 chr4:120327624 NA 0.69 10.92 0.51 6.06e-24 Educational attainment; LUSC cis rs7712401 0.546 rs10044921 chr5:122179357 C/G cg19077854 chr5:122220652 SNX24 0.4 8.86 0.44 4.98e-17 Mean platelet volume; LUSC trans rs4843747 0.671 rs8062855 chr16:88106941 T/C cg26811252 chr16:29126840 RRN3P2 0.57 9.15 0.45 5.58e-18 Menopause (age at onset); LUSC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg23093090 chr10:104574429 C10orf26 -0.39 -7.26 -0.37 2.75e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs2594989 0.779 rs2596815 chr3:11594930 A/G cg00170343 chr3:11313890 ATG7 -0.49 -6.17 -0.32 1.94e-9 Circulating chemerin levels; LUSC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg26727032 chr16:67993705 SLC12A4 -0.44 -5.88 -0.31 9.79e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7903847 0.642 rs11189200 chr10:99156273 C/G cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12541335 0.603 rs9792127 chr8:22180334 G/A cg18135555 chr8:22132992 PIWIL2 0.38 7.59 0.38 3.33e-13 Hypertriglyceridemia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14138432 chr3:196295511 WDR53;FBXO45 -0.4 -5.95 -0.31 6.76e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6601327 0.586 rs6601340 chr8:9461315 A/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.41 -0.33 5.04e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7666738 0.515 rs11733968 chr4:98906448 A/C cg03676636 chr4:99064102 C4orf37 -0.31 -6.57 -0.34 1.92e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC cis rs7605827 0.930 rs765432 chr2:15561440 C/T cg19274914 chr2:15703543 NA -0.48 -9.32 -0.45 1.6e-18 Educational attainment (years of education); LUSC cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg04586622 chr2:25135609 ADCY3 0.42 8.87 0.44 4.48e-17 Body mass index; LUSC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg03289416 chr15:75166202 SCAMP2 0.45 6.87 0.35 3.13e-11 Breast cancer; LUSC cis rs7098414 0.511 rs4934126 chr10:82151598 A/G cg00277334 chr10:82204260 NA -0.59 -9.81 -0.47 4.05e-20 Post bronchodilator FEV1; LUSC cis rs617219 0.819 rs6889383 chr5:78597058 T/C cg24856658 chr5:78533917 JMY 0.3 5.93 0.31 7.68e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg00166722 chr3:10149974 C3orf24 0.56 7.54 0.38 4.61e-13 Alzheimer's disease; LUSC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg20821713 chr7:1055600 C7orf50 -0.48 -6.23 -0.32 1.37e-9 Bronchopulmonary dysplasia; LUSC cis rs9653442 0.564 rs10197987 chr2:100790783 A/T cg07810366 chr2:100720526 AFF3 -0.42 -7.1 -0.36 7.37e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg12564285 chr5:131593104 PDLIM4 0.44 8.13 0.41 8.6e-15 Breast cancer; LUSC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.62 -10.52 -0.5 1.51e-22 IgG glycosylation; LUSC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg24562669 chr7:97807699 LMTK2 -0.48 -8.44 -0.42 1.01e-15 Breast cancer; LUSC trans rs8072100 0.817 rs6505049 chr17:45675781 G/A cg04995722 chr7:26192034 NFE2L3 0.39 6.24 0.32 1.33e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs597583 0.789 rs3741280 chr11:117403235 G/T cg00716016 chr9:3180374 NA -0.39 -6.1 -0.32 2.92e-9 Putamen volume; LUSC trans rs6601327 0.585 rs11249934 chr8:9510830 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.45 0.33 3.85e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs2692947 0.673 rs4907279 chr2:96399968 G/C cg22654517 chr2:96458247 NA 0.35 6.51 0.34 2.71e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.8 0.39 8.08e-14 Major depressive disorder; LUSC cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg22709100 chr7:91322751 NA 0.39 5.8 0.3 1.56e-8 Breast cancer; LUSC cis rs7223966 0.921 rs3020612 chr17:61960878 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.16 0.36 5.3e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs17270561 1.000 rs12200962 chr6:25828986 T/C cg16482183 chr6:26056742 HIST1H1C 0.78 9.86 0.47 2.69e-20 Iron status biomarkers; LUSC cis rs11229555 0.645 rs4347409 chr11:58176252 C/T cg15696309 chr11:58395628 NA 0.62 7.86 0.4 5.41e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6987853 0.933 rs2974355 chr8:42414117 C/T cg09913449 chr8:42400586 C8orf40 0.49 8.2 0.41 5.31e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg04155289 chr7:94953770 PON1 -0.36 -6.12 -0.32 2.56e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1691799 0.806 rs1168319 chr12:66744857 T/A cg16791601 chr12:66731901 HELB -0.71 -12.51 -0.56 1.04e-29 White blood cell count (basophil); LUSC cis rs7107174 1.000 rs1385600 chr11:77936166 C/T cg02023728 chr11:77925099 USP35 -0.45 -6.96 -0.36 1.76e-11 Testicular germ cell tumor; LUSC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.14 -0.8 3.2e-75 Height; LUSC cis rs5769707 0.681 rs4622843 chr22:50036916 T/G cg20744362 chr22:50050164 C22orf34 0.38 7.24 0.37 3.08e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg07636037 chr3:49044803 WDR6 1.05 18.78 0.72 3.21e-54 Parkinson's disease; LUSC cis rs11098499 0.775 rs10021601 chr4:120282563 G/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs73001065 0.636 rs56241616 chr19:19506092 C/T cg03709012 chr19:19516395 GATAD2A 0.95 8.75 0.43 1.11e-16 LDL cholesterol; LUSC cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg20283391 chr11:68216788 NA 0.57 8.04 0.4 1.55e-14 Total body bone mineral density; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23797073 chr6:15663448 DTNBP1 0.43 7.04 0.36 1.13e-11 Triglycerides; LUSC cis rs10088262 0.629 rs9918907 chr8:124816862 A/G cg20713898 chr8:124780851 FAM91A1 -0.55 -7.51 -0.38 5.55e-13 Pancreatic cancer; LUSC cis rs977987 0.806 rs8050769 chr16:75388434 C/T cg03315344 chr16:75512273 CHST6 0.51 9.67 0.47 1.19e-19 Dupuytren's disease; LUSC cis rs7246967 0.673 rs67631531 chr19:22830466 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs41271473 0.526 rs12136157 chr1:228703236 T/C cg16512390 chr1:228756714 NA 0.63 8.02 0.4 1.8e-14 Chronic lymphocytic leukemia; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg18110333 chr6:292329 DUSP22 0.74 12.28 0.56 7.11e-29 Menopause (age at onset); LUSC cis rs9583531 0.843 rs7999702 chr13:111382264 A/C cg24331049 chr13:111365604 ING1 -0.64 -7.53 -0.38 4.93e-13 Coronary artery disease; LUSC cis rs9951602 0.850 rs56367211 chr18:76677563 G/T cg00806245 chr18:76673096 NA 0.43 6.0 0.31 5.08e-9 Obesity-related traits; LUSC cis rs7712401 0.715 rs424262 chr5:122348012 G/A cg19077854 chr5:122220652 SNX24 -0.41 -8.85 -0.44 5.29e-17 Mean platelet volume; LUSC cis rs7178572 1.000 rs952472 chr15:77776562 A/C cg22256960 chr15:77711686 NA -0.55 -9.2 -0.45 4.07e-18 Type 2 diabetes; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg14893161 chr1:205819251 PM20D1 0.92 18.09 0.7 1.88e-51 Menarche (age at onset); LUSC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg16680214 chr1:154839983 KCNN3 -0.54 -10.34 -0.49 6.5e-22 Prostate cancer; LUSC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC cis rs1904096 0.506 rs13434570 chr4:95168019 T/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.34 -0.41 2.03e-15 Type 2 diabetes; LUSC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg11608241 chr8:8085544 FLJ10661 0.44 6.2 0.32 1.63e-9 Neuroticism; LUSC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg11632617 chr15:75315747 PPCDC -0.52 -6.73 -0.35 7.58e-11 Blood trace element (Zn levels); LUSC cis rs9462027 0.628 rs9462026 chr6:34797033 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.76 -0.3 1.86e-8 Systemic lupus erythematosus; LUSC cis rs10740039 0.671 rs7919726 chr10:62449506 T/C cg18175470 chr10:62150864 ANK3 -0.44 -6.67 -0.34 1.08e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs921968 0.541 rs17462853 chr2:219345637 T/G cg02176678 chr2:219576539 TTLL4 -0.74 -14.3 -0.62 1.59e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs11677416 1.000 rs59674541 chr2:113553824 A/T cg27083787 chr2:113543245 IL1A 0.46 7.18 0.37 4.69e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.19 0.45 4.24e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2835872 0.828 rs2835838 chr21:38990994 A/G cg20424643 chr21:39039972 KCNJ6 0.37 5.83 0.3 1.28e-8 Electroencephalographic traits in alcoholism; LUSC cis rs17685 0.712 rs7778735 chr7:75770237 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs8073060 0.544 rs2626626 chr17:34026717 A/G cg19694781 chr19:47549865 TMEM160 -1.13 -17.99 -0.7 4.71e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01325958 chr17:37793326 STARD3 -0.51 -6.27 -0.32 1.12e-9 Bipolar disorder and schizophrenia; LUSC cis rs6977660 0.943 rs10270447 chr7:19849823 C/G cg05791153 chr7:19748676 TWISTNB -0.51 -5.75 -0.3 1.99e-8 Thyroid stimulating hormone; LUSC cis rs6500602 0.682 rs3761679 chr16:4457907 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 7.32 0.37 1.85e-12 Schizophrenia; LUSC cis rs34779708 0.966 rs10508816 chr10:35459976 G/A cg04310649 chr10:35416472 CREM -0.4 -6.25 -0.32 1.26e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs79976124 0.797 rs79522358 chr6:66641140 C/G cg07460842 chr6:66804631 NA 0.71 8.87 0.44 4.36e-17 Type 2 diabetes; LUSC cis rs6500395 1.000 rs3826174 chr16:48591012 T/C cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs4689592 0.503 rs66885632 chr4:7053738 T/C cg07817883 chr1:32538562 TMEM39B 0.6 6.08 0.32 3.29e-9 Monocyte percentage of white cells; LUSC cis rs2806561 0.729 rs35919647 chr1:23326072 C/T cg19743168 chr1:23544995 NA -0.42 -8.7 -0.43 1.54e-16 Height; LUSC cis rs7903847 0.620 rs10882907 chr10:99125788 C/G cg08345082 chr10:99160200 RRP12 0.31 6.29 0.33 9.86e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg27129171 chr3:47204927 SETD2 0.73 12.6 0.57 4.74e-30 Colorectal cancer; LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg18099408 chr3:52552593 STAB1 -0.43 -6.98 -0.36 1.58e-11 Bipolar disorder; LUSC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00475322 chr7:917719 C7orf20 -0.44 -6.54 -0.34 2.34e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs7103648 0.966 rs10769263 chr11:47417183 A/C cg20307385 chr11:47447363 PSMC3 0.97 18.83 0.72 2.07e-54 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg26441486 chr22:50317300 CRELD2 0.52 7.95 0.4 2.85e-14 Schizophrenia; LUSC cis rs7223966 0.921 rs2727300 chr17:61965398 G/A cg11494091 chr17:61959527 GH2 0.37 6.1 0.32 2.94e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg02782426 chr3:40428986 ENTPD3 0.33 6.26 0.32 1.16e-9 Renal cell carcinoma; LUSC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg05585544 chr11:47624801 NA -0.41 -7.1 -0.36 7.39e-12 Neuroticism; LUSC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg17376030 chr22:41985996 PMM1 -0.46 -5.81 -0.3 1.47e-8 Vitiligo; LUSC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08109568 chr15:31115862 NA -0.59 -8.22 -0.41 4.66e-15 Huntington's disease progression; LUSC cis rs8133932 0.654 rs413517 chr21:47347545 C/G cg14185626 chr21:47401492 COL6A1 -0.44 -5.65 -0.3 3.37e-8 Schizophrenia; LUSC trans rs57221529 0.766 rs1399381 chr5:589853 G/T cg25482853 chr8:67687455 SGK3 1.18 16.74 0.68 4.07e-46 Lung disease severity in cystic fibrosis; LUSC cis rs427394 0.664 rs274722 chr5:6718668 C/T cg10857441 chr5:6722123 POLS -0.44 -8.56 -0.42 4.23e-16 Menopause (age at onset); LUSC cis rs5769707 0.521 rs5769720 chr22:50062133 G/C cg20744362 chr22:50050164 C22orf34 0.35 6.29 0.33 9.69e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs955333 1.000 rs56306994 chr6:154946059 T/C cg20019720 chr6:154832845 CNKSR3 0.42 5.86 0.31 1.12e-8 Diabetic kidney disease; LUSC cis rs4654899 0.833 rs10916858 chr1:21086602 C/G cg01072550 chr1:21505969 NA -0.47 -7.06 -0.36 9.91e-12 Superior frontal gyrus grey matter volume; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg04025307 chr7:1156635 C7orf50 0.45 7.03 0.36 1.14e-11 Longevity;Endometriosis; LUSC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.82 -0.3 1.37e-8 Tonsillectomy; LUSC trans rs61931739 0.534 rs4001713 chr12:34154195 A/C cg13010199 chr12:38710504 ALG10B -0.51 -7.71 -0.39 1.41e-13 Morning vs. evening chronotype; LUSC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg06636001 chr8:8085503 FLJ10661 0.58 8.44 0.42 9.68e-16 Neuroticism; LUSC trans rs6767049 0.510 rs4380427 chr3:20310729 G/C cg15029475 chr5:3028202 NA 0.28 6.07 0.32 3.57e-9 Temperament (bipolar disorder); LUSC cis rs72781680 0.898 rs72790310 chr2:24116716 C/T cg20701182 chr2:24300061 SF3B14 0.55 5.83 0.3 1.32e-8 Lymphocyte counts; LUSC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC trans rs8026898 1.000 rs8026898 chr15:69991417 G/A cg27385734 chr18:15003734 NA 0.3 5.98 0.31 5.64e-9 Rheumatoid arthritis; LUSC cis rs2976388 1.000 rs2717562 chr8:143776668 T/C cg17252645 chr8:143867129 LY6D -0.38 -6.5 -0.34 2.85e-10 Urinary tract infection frequency; LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4363385 0.642 rs58124215 chr1:152916375 C/T cg07796016 chr1:152779584 LCE1C -0.5 -7.49 -0.38 6.21e-13 Inflammatory skin disease; LUSC cis rs17767294 0.708 rs72848753 chr6:27878269 C/G cg08851530 chr6:28072375 NA 1.31 8.29 0.41 2.8e-15 Parkinson's disease; LUSC cis rs7903847 0.596 rs10882934 chr10:99170995 T/G cg20016023 chr10:99160130 RRP12 -0.33 -7.95 -0.4 2.9e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg06618935 chr21:46677482 NA -0.4 -8.06 -0.4 1.37e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg05347473 chr6:146136440 FBXO30 0.37 6.27 0.32 1.11e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg13072238 chr3:49761600 GMPPB 0.36 5.84 0.3 1.22e-8 Intelligence (multi-trait analysis); LUSC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs11098499 0.954 rs59866101 chr4:120296591 T/G cg25214090 chr10:38739885 LOC399744 0.55 8.01 0.4 1.89e-14 Corneal astigmatism; LUSC cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -8.94 -0.44 2.67e-17 Monocyte percentage of white cells; LUSC cis rs76878669 0.561 rs2279861 chr11:66133336 A/G cg18002602 chr11:66138449 SLC29A2 0.45 8.08 0.4 1.17e-14 Educational attainment (years of education); LUSC cis rs28655083 0.956 rs7184167 chr16:77069451 T/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.42 -6.33 -0.33 7.82e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs4319547 0.956 rs7397990 chr12:123119472 T/C cg23029597 chr12:123009494 RSRC2 -0.66 -9.02 -0.44 1.51e-17 Body mass index; LUSC cis rs9283706 0.548 rs10052424 chr5:66356632 G/T cg11590213 chr5:66331682 MAST4 0.45 6.72 0.34 8.05e-11 Coronary artery disease; LUSC cis rs422249 0.512 rs174546 chr11:61569830 C/T cg19610905 chr11:61596333 FADS2 -0.55 -8.27 -0.41 3.13e-15 Trans fatty acid levels; LUSC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg17252645 chr8:143867129 LY6D 0.38 6.68 0.34 1.01e-10 Urinary tract infection frequency; LUSC cis rs68170813 0.559 rs77727587 chr7:106815754 C/G cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.38e-20 Coronary artery disease; LUSC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg17724175 chr1:150552817 MCL1 0.38 6.79 0.35 5.04e-11 Tonsillectomy; LUSC cis rs11190604 0.943 rs9420792 chr10:102258439 C/T cg07080220 chr10:102295463 HIF1AN 0.68 9.17 0.45 4.82e-18 Palmitoleic acid (16:1n-7) levels; LUSC trans rs7726839 0.574 rs72707007 chr5:661856 T/C cg08313168 chr12:7315531 NA 0.47 5.96 0.31 6.34e-9 Obesity-related traits; LUSC trans rs7824557 0.872 rs6601577 chr8:11102682 C/G cg08975724 chr8:8085496 FLJ10661 0.43 6.59 0.34 1.75e-10 Retinal vascular caliber; LUSC trans rs6502050 0.835 rs7221544 chr17:80087337 C/T cg07393940 chr7:158741817 NA -0.38 -6.87 -0.35 3.1e-11 Life satisfaction; LUSC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.56 8.33 0.41 2.12e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12637928 0.580 rs4682590 chr3:110212334 T/C cg17371621 chr15:61264283 RORA 0.36 6.03 0.31 4.4e-9 Neuroticism; LUSC trans rs72674100 1.000 rs77493600 chr4:97980332 A/G cg09670535 chr1:18959427 PAX7 -0.63 -6.47 -0.33 3.55e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg07606381 chr6:8435919 SLC35B3 0.75 12.65 0.57 3e-30 Motion sickness; LUSC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg24578937 chr1:2090814 PRKCZ 0.46 10.28 0.49 9.95e-22 Height; LUSC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg06582575 chr6:163149167 PACRG;PARK2 1.1 14.12 0.61 7.99e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg18758796 chr5:131593413 PDLIM4 0.43 7.1 0.36 7.57e-12 Breast cancer; LUSC cis rs2820315 1.000 rs2678204 chr1:201800511 T/G cg10061532 chr1:201886748 LMOD1 0.25 5.7 0.3 2.68e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs1506636 0.924 rs2402668 chr7:123296605 T/A cg03229431 chr7:123269106 ASB15 -0.65 -10.62 -0.5 6.66e-23 Plateletcrit;Platelet count; LUSC cis rs6087771 0.642 rs6060411 chr20:30222139 T/C cg21427119 chr20:30132790 HM13 -0.38 -6.01 -0.31 4.83e-9 Subcortical brain region volumes;Putamen volume; LUSC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg16989086 chr20:62203971 PRIC285 0.46 6.41 0.33 5.09e-10 Glioblastoma; LUSC cis rs6424115 0.830 rs2229585 chr1:24200921 T/C cg10978503 chr1:24200527 CNR2 0.54 13.3 0.59 1.11e-32 Immature fraction of reticulocytes; LUSC cis rs34779708 0.931 rs13376871 chr10:35369056 A/G cg03585969 chr10:35415529 CREM 0.59 8.83 0.44 6.06e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs950027 0.620 rs1153857 chr15:45659095 G/T cg14582100 chr15:45693742 SPATA5L1 0.46 8.62 0.43 2.7e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg27094323 chr7:1216898 NA -0.42 -6.99 -0.36 1.54e-11 Longevity;Endometriosis; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg24813613 chr7:1882135 MAD1L1 -0.45 -7.74 -0.39 1.17e-13 Bipolar disorder and schizophrenia; LUSC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg15790184 chr11:494944 RNH1 0.49 6.91 0.35 2.5e-11 Systemic lupus erythematosus; LUSC cis rs259282 0.646 rs34182086 chr19:33125823 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.69 10.51 0.5 1.59e-22 Schizophrenia; LUSC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg18876405 chr7:65276391 NA -0.72 -12.6 -0.57 4.65e-30 Aortic root size; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.5 -8.41 -0.42 1.17e-15 Prudent dietary pattern; LUSC cis rs17401966 0.809 rs12406943 chr1:10308545 T/C cg19773385 chr1:10388646 KIF1B -0.52 -8.98 -0.44 1.98e-17 Hepatocellular carcinoma; LUSC cis rs63406760 1 rs63406760 chr12:123742692 TG/T cg05973401 chr12:123451056 ABCB9 0.52 6.43 0.33 4.29e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg06740227 chr12:86229804 RASSF9 0.39 6.33 0.33 7.71e-10 Major depressive disorder; LUSC cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg17173187 chr15:85201210 NMB 0.38 6.66 0.34 1.16e-10 Schizophrenia; LUSC cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg18129178 chr5:148520854 ABLIM3 -0.67 -9.95 -0.48 1.3e-20 Breast cancer; LUSC cis rs17685 0.890 rs76021834 chr7:75607155 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -5.65 -0.3 3.43e-8 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs8056893 0.523 rs11647636 chr16:68369740 C/T cg02226672 chr16:68398533 SMPD3 0.31 5.65 0.3 3.48e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.76 0.84 8.98e-89 Chronic sinus infection; LUSC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg03526776 chr6:41159608 TREML2 0.33 6.26 0.32 1.2e-9 Alzheimer's disease (late onset); LUSC cis rs6547741 0.844 rs9678851 chr2:27887034 C/A cg27432699 chr2:27873401 GPN1 -0.9 -17.9 -0.7 1.03e-50 Oral cavity cancer; LUSC cis rs3790645 1.000 rs897641 chr1:26881806 C/A cg17456097 chr1:26900765 RPS6KA1 0.42 6.08 0.32 3.36e-9 Glucose homeostasis traits; LUSC cis rs7191700 0.601 rs243329 chr16:11352313 A/T cg00044050 chr16:11439710 C16orf75 0.67 11.92 0.55 1.51e-27 Multiple sclerosis; LUSC cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg16230307 chr14:35515116 FAM177A1 0.79 10.05 0.48 6.13e-21 Psoriasis; LUSC cis rs9467711 0.606 rs2073529 chr6:26375159 C/T cg09904177 chr6:26538194 HMGN4 0.62 5.97 0.31 5.99e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00608362 chr4:128802003 PLK4 0.46 6.52 0.34 2.6e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.09 0.61 1.02e-35 Platelet count; LUSC cis rs28647808 0.881 rs28602295 chr9:136267471 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21659725 chr3:3221576 CRBN -0.88 -18.04 -0.7 2.96e-51 Intelligence (multi-trait analysis); LUSC cis rs3008870 0.755 rs1024230 chr1:67512920 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.65 9.71 0.47 8.24e-20 Lymphocyte percentage of white cells; LUSC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg11764359 chr7:65958608 NA 0.61 9.33 0.45 1.55e-18 Aortic root size; LUSC cis rs7267979 0.789 rs4815429 chr20:25521611 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.8 -16.58 -0.67 1.83e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs703842 1.000 rs11172351 chr12:58213485 C/T cg00677455 chr12:58241039 CTDSP2 0.65 9.14 0.45 6.01e-18 Multiple sclerosis; LUSC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg18240062 chr17:79603768 NPLOC4 -0.57 -9.84 -0.47 3.25e-20 Eye color traits; LUSC cis rs12900413 0.687 rs12908343 chr15:90319095 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.85 -0.31 1.15e-8 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg06562570 chr14:97263560 VRK1 -0.46 -6.27 -0.32 1.12e-9 Hepatitis; LUSC cis rs77106637 1.000 rs11600585 chr11:72727840 A/G cg03713592 chr11:72463424 ARAP1 0.76 8.96 0.44 2.38e-17 Type 2 diabetes; LUSC cis rs909674 0.734 rs1005522 chr22:39845898 C/A cg02038168 chr22:39784481 NA -0.42 -5.99 -0.31 5.34e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg04166393 chr7:2884313 GNA12 0.45 6.11 0.32 2.72e-9 Height; LUSC cis rs6028335 0.502 rs6028235 chr20:37608550 A/G cg27552599 chr20:37590471 DHX35 0.45 7.52 0.38 4.97e-13 Alcohol and nicotine co-dependence; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg08859206 chr1:53392774 SCP2 -0.59 -11.0 -0.52 3.08e-24 Monocyte count; LUSC cis rs8038465 0.622 rs2509 chr15:73859488 A/T cg15420318 chr15:73925796 NPTN -0.53 -8.66 -0.43 1.98e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2806561 0.765 rs1738470 chr1:23511911 G/A cg12483005 chr1:23474871 LUZP1 0.43 6.69 0.34 9.54e-11 Height; LUSC cis rs11958404 0.932 rs72816541 chr5:157414686 G/A cg05962755 chr5:157440814 NA 0.49 6.08 0.32 3.24e-9 IgG glycosylation; LUSC cis rs9361491 0.657 rs7382016 chr6:79455781 A/T cg05283184 chr6:79620031 NA 0.33 5.95 0.31 6.76e-9 Intelligence (multi-trait analysis); LUSC cis rs9467773 1.000 rs4713006 chr6:26519872 A/G cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.11e-18 Intelligence (multi-trait analysis); LUSC cis rs2354432 0.607 rs7537279 chr1:146673642 A/G cg25205988 chr1:146714368 CHD1L 1.05 8.62 0.43 2.81e-16 Mitochondrial DNA levels; LUSC cis rs9462027 0.651 rs4259246 chr6:34803947 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.8 -0.3 1.56e-8 Systemic lupus erythematosus; LUSC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg10018233 chr7:150070692 REPIN1 0.38 6.61 0.34 1.48e-10 Blood protein levels;Circulating chemerin levels; LUSC trans rs2797160 1.000 rs1739378 chr6:126012262 C/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.89 0.35 2.82e-11 Endometrial cancer; LUSC cis rs11158026 0.574 rs58055971 chr14:55436324 C/T cg04306507 chr14:55594613 LGALS3 0.4 7.23 0.37 3.26e-12 Parkinson's disease; LUSC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.8e-13 Schizophrenia; LUSC cis rs847577 0.748 rs940432 chr7:97716483 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.32 0.37 1.86e-12 Breast cancer; LUSC cis rs1801251 1.000 rs1947105 chr2:233721455 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.7 0.34 8.86e-11 Coronary artery disease; LUSC cis rs8060686 0.641 rs57408712 chr16:68242573 G/C cg04539111 chr16:67997858 SLC12A4 -0.43 -5.71 -0.3 2.51e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs9309473 0.950 rs7596773 chr2:73846000 C/T cg20560298 chr2:73613845 ALMS1 -0.43 -6.11 -0.32 2.79e-9 Metabolite levels; LUSC cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.67 0.6 4.14e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17270561 0.609 rs4145217 chr6:25743997 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.73 0.39 1.29e-13 Iron status biomarkers; LUSC cis rs10751667 0.643 rs10902238 chr11:944810 G/A ch.11.42038R chr11:967971 AP2A2 0.41 6.08 0.32 3.21e-9 Alzheimer's disease (late onset); LUSC cis rs12681288 0.823 rs2701905 chr8:1003482 T/C cg04851639 chr8:1020857 NA -0.36 -7.63 -0.39 2.45e-13 Schizophrenia; LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg01616529 chr11:638424 DRD4 -0.35 -6.02 -0.31 4.64e-9 Systemic lupus erythematosus; LUSC cis rs2742234 0.541 rs1254958 chr10:43702143 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 6.99 0.36 1.53e-11 Hirschsprung disease; LUSC cis rs9388451 1.000 rs9388451 chr6:126090377 A/G cg05901451 chr6:126070800 HEY2 -0.93 -18.02 -0.7 3.37e-51 Brugada syndrome; LUSC cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.88 -0.51 8.54e-24 Chronic sinus infection; LUSC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.08 15.68 0.65 6.54e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6733011 0.559 rs6711022 chr2:99449536 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -7.07 -0.36 8.96e-12 Bipolar disorder; LUSC trans rs7937682 0.575 rs1940391 chr11:111776891 G/A cg18187862 chr3:45730750 SACM1L -0.55 -6.98 -0.36 1.6e-11 Primary sclerosing cholangitis; LUSC cis rs9814567 1.000 rs7374158 chr3:134270156 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9311676 0.632 rs11130646 chr3:58447013 C/G cg13750441 chr3:58318267 PXK 0.35 6.81 0.35 4.58e-11 Systemic lupus erythematosus; LUSC cis rs3749237 1.000 rs4768 chr3:49758764 A/G cg03060546 chr3:49711283 APEH 0.57 7.91 0.4 3.89e-14 Resting heart rate; LUSC cis rs34375054 0.525 rs10846829 chr12:125595058 G/C cg00522288 chr12:125625016 AACS -0.32 -6.14 -0.32 2.28e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7246967 0.673 rs73028776 chr19:22813740 A/C cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs8114671 0.585 rs2236271 chr20:33523840 G/T cg24642439 chr20:33292090 TP53INP2 -0.44 -6.49 -0.33 3.17e-10 Height; LUSC cis rs76878669 0.561 rs2279862 chr11:66135179 C/T cg24851651 chr11:66362959 CCS -0.36 -5.68 -0.3 2.92e-8 Educational attainment (years of education); LUSC cis rs11155671 0.530 rs6557133 chr6:150195384 G/T cg13206674 chr6:150067644 NUP43 0.4 5.69 0.3 2.85e-8 Testicular germ cell tumor; LUSC cis rs9921338 0.961 rs8048768 chr16:11396840 T/C cg00044050 chr16:11439710 C16orf75 -0.48 -6.51 -0.34 2.73e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.91 0.31 8.31e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg18402987 chr7:1209562 NA 0.71 7.63 0.39 2.45e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs514406 0.536 rs878957 chr1:53197559 C/T cg06600287 chr1:53387719 ECHDC2 0.3 6.16 0.32 2.1e-9 Monocyte count; LUSC trans rs9291683 0.610 rs993173 chr4:10323935 T/C cg26043149 chr18:55253948 FECH -0.55 -8.51 -0.42 5.94e-16 Bone mineral density; LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg21285383 chr16:89894308 SPIRE2 -0.33 -6.97 -0.36 1.68e-11 Vitiligo; LUSC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.48 -0.33 3.21e-10 Lung cancer; LUSC trans rs2055729 0.710 rs114038384 chr8:9737519 T/A cg06636001 chr8:8085503 FLJ10661 0.49 6.17 0.32 2.01e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg19046167 chr17:80928561 B3GNTL1 0.49 7.05 0.36 1.01e-11 Glycated hemoglobin levels; LUSC cis rs877282 0.735 rs111609055 chr10:826539 A/G cg13775593 chr10:823151 NA 0.31 6.22 0.32 1.48e-9 Uric acid levels; LUSC cis rs1568889 0.838 rs7127069 chr11:28325412 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 12.82 0.57 6.93e-31 Bipolar disorder; LUSC cis rs4629710 0.592 rs13200165 chr6:131549167 G/C cg12606694 chr6:131520996 AKAP7 0.61 9.3 0.45 1.83e-18 Multiple myeloma (IgH translocation); LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.08 -0.32 3.33e-9 Bipolar disorder and schizophrenia; LUSC cis rs748404 0.586 rs2584700 chr15:43685332 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.46 6.67 0.34 1.09e-10 Lung cancer; LUSC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg23758822 chr17:41437982 NA 0.98 18.21 0.71 6.17e-52 Menopause (age at onset); LUSC cis rs2760061 0.583 rs708113 chr1:228192753 T/A cg18477163 chr1:228402036 OBSCN 0.53 9.23 0.45 3.15e-18 Diastolic blood pressure; LUSC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg12963246 chr6:28129442 ZNF389 0.37 5.71 0.3 2.51e-8 Parkinson's disease; LUSC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 6.15 0.32 2.23e-9 Parkinson's disease; LUSC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg00166722 chr3:10149974 C3orf24 0.39 5.81 0.3 1.43e-8 Alzheimer's disease; LUSC cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg24450063 chr1:156163899 SLC25A44 1.18 29.43 0.85 8.55e-95 Testicular germ cell tumor; LUSC cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg12863693 chr15:85201151 NMB -0.34 -6.42 -0.33 4.79e-10 Schizophrenia; LUSC cis rs2227930 0.506 rs10935460 chr3:142047041 G/A cg16271453 chr3:142027066 XRN1 -0.55 -9.95 -0.48 1.35e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs1577917 1.000 rs1337844 chr6:86677273 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.79e-10 Response to antipsychotic treatment; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg23193613 chr8:144267725 NA -0.24 -6.12 -0.32 2.56e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2294693 0.945 rs9462668 chr6:41004194 T/C cg14769373 chr6:40998127 UNC5CL -0.51 -7.07 -0.36 9.23e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs2282802 0.685 rs4913079 chr5:139683029 A/G cg26211634 chr5:139558579 C5orf32 0.39 7.33 0.37 1.75e-12 Intelligence (multi-trait analysis); LUSC cis rs6712932 0.962 rs2053241 chr2:105842228 G/A cg22878388 chr2:105853796 NA -0.34 -6.22 -0.32 1.5e-9 Type 2 diabetes; LUSC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg09165964 chr15:75287851 SCAMP5 0.56 8.46 0.42 8.72e-16 Breast cancer; LUSC cis rs2224391 0.628 rs2753236 chr6:5252214 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.73 -0.35 7.62e-11 Height; LUSC trans rs7819412 0.838 rs3021494 chr8:10983534 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.72 -0.35 7.82e-11 Triglycerides; LUSC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg06640241 chr16:89574553 SPG7 -0.68 -9.3 -0.45 1.89e-18 Multiple myeloma (IgH translocation); LUSC cis rs748404 0.631 rs11070399 chr15:43646347 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.33 0.33 7.85e-10 Lung cancer; LUSC cis rs2120019 1.000 rs2120019 chr15:75334184 T/C cg11632617 chr15:75315747 PPCDC -0.5 -6.45 -0.33 4.03e-10 Blood trace element (Zn levels); LUSC cis rs6733011 0.578 rs1878585 chr2:99501698 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.79 -0.3 1.59e-8 Bipolar disorder; LUSC cis rs10464366 0.560 rs11763728 chr7:39145862 C/T cg21665744 chr7:39171113 POU6F2 0.41 6.61 0.34 1.5e-10 IgG glycosylation; LUSC cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.81 -0.51 1.5e-23 Alzheimer's disease (late onset); LUSC trans rs11039798 0.920 rs11039940 chr11:48716316 C/T cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC trans rs8072100 0.840 rs9893901 chr17:45506682 T/G cg04995722 chr7:26192034 NFE2L3 -0.39 -6.33 -0.33 7.84e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13385 0.769 rs7705999 chr5:139576049 T/A cg26211634 chr5:139558579 C5orf32 0.44 6.59 0.34 1.76e-10 Atrial fibrillation; LUSC cis rs9308433 0.529 rs3767842 chr1:214498306 C/T cg06198575 chr1:214491504 SMYD2 0.45 7.06 0.36 9.75e-12 IgG glycosylation; LUSC trans rs12145833 0.596 rs12123491 chr1:243297924 C/G cg25284624 chr1:224180302 NA 0.67 6.49 0.33 3.18e-10 Obesity (early onset extreme); LUSC cis rs3093024 0.967 rs1571878 chr6:167540842 C/T cg07741184 chr6:167504864 NA -0.48 -8.42 -0.42 1.1e-15 Rheumatoid arthritis; LUSC cis rs611744 0.647 rs7016198 chr8:109262752 G/A cg21045802 chr8:109455806 TTC35 0.43 6.63 0.34 1.38e-10 Dupuytren's disease; LUSC cis rs6942756 0.806 rs7788327 chr7:128986519 C/T cg02491457 chr7:128862824 NA -0.46 -7.03 -0.36 1.14e-11 White matter hyperintensity burden; LUSC cis rs11190604 0.767 rs10883477 chr10:102161396 A/G cg07080220 chr10:102295463 HIF1AN 0.59 7.89 0.4 4.34e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs965604 1.000 rs4362358 chr15:78796104 C/T cg18825076 chr15:78729989 IREB2 -0.43 -6.82 -0.35 4.31e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6582630 0.555 rs2197308 chr12:38281261 A/G cg13010199 chr12:38710504 ALG10B -0.46 -6.89 -0.35 2.76e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs73198271 0.740 rs10105690 chr8:8649232 G/T cg15556689 chr8:8085844 FLJ10661 -0.45 -5.99 -0.31 5.51e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg16414030 chr3:133502952 NA -0.4 -6.02 -0.31 4.5e-9 Iron status biomarkers; LUSC cis rs7584330 0.910 rs6737914 chr2:238393434 A/G cg16989719 chr2:238392110 NA -0.42 -7.34 -0.37 1.68e-12 Prostate cancer; LUSC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg27535305 chr1:53392650 SCP2 -0.49 -9.55 -0.46 2.99e-19 Monocyte count; LUSC cis rs1983891 0.955 rs6917029 chr6:41548540 C/G cg15051332 chr6:41514432 FOXP4 0.39 5.74 0.3 2.12e-8 Prostate cancer; LUSC cis rs17125944 0.505 rs2295827 chr14:53174981 C/T cg00686598 chr14:53173677 PSMC6 1.12 10.51 0.5 1.65e-22 Alzheimer's disease (late onset); LUSC cis rs9653442 0.564 rs7565895 chr2:100774773 G/A cg07810366 chr2:100720526 AFF3 -0.45 -7.65 -0.39 2.21e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2235649 0.746 rs113666107 chr16:1848642 C/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.11 -0.32 2.74e-9 Blood metabolite levels; LUSC cis rs12681288 0.792 rs12678495 chr8:1000858 C/G cg04851639 chr8:1020857 NA -0.38 -8.01 -0.4 1.92e-14 Schizophrenia; LUSC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg10560079 chr2:191398806 TMEM194B 0.45 7.45 0.38 8.21e-13 Pulse pressure; LUSC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 12.87 0.58 4.57e-31 Platelet count; LUSC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg20891283 chr12:69753455 YEATS4 0.82 15.09 0.64 1.34e-39 Blood protein levels; LUSC cis rs300703 0.654 rs393277 chr2:121539 G/T cg21211680 chr2:198530 NA -0.78 -8.35 -0.42 1.84e-15 Blood protein levels; LUSC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg23982607 chr1:1823379 GNB1 -0.73 -14.94 -0.63 5.09e-39 Body mass index; LUSC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg05295671 chr13:79234353 RNF219 0.46 6.01 0.31 4.86e-9 Large artery stroke; LUSC cis rs497273 0.511 rs1151862 chr12:121331285 G/A cg02419362 chr12:121203948 SPPL3 -0.43 -7.97 -0.4 2.49e-14 Systemic lupus erythematosus; LUSC cis rs3096299 0.679 rs3102338 chr16:89442250 C/G cg06640241 chr16:89574553 SPG7 0.66 9.79 0.47 4.5e-20 Multiple myeloma (IgH translocation); LUSC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg00933542 chr6:150070202 PCMT1 0.29 5.87 0.31 1.05e-8 Lung cancer; LUSC cis rs208515 0.525 rs12204452 chr6:66680325 C/T cg07460842 chr6:66804631 NA 1.05 14.32 0.62 1.33e-36 Exhaled nitric oxide levels; LUSC cis rs2455601 1.000 rs12223690 chr11:8901824 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.5 -7.66 -0.39 2e-13 Schizophrenia; LUSC cis rs7264396 0.561 rs6058388 chr20:34571846 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -7.24 -0.37 3.02e-12 Total cholesterol levels; LUSC cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg16405210 chr4:1374714 KIAA1530 -0.55 -8.48 -0.42 7.39e-16 Obesity-related traits; LUSC cis rs62432291 0.681 rs418859 chr6:159649695 A/T cg14500486 chr6:159655392 FNDC1 0.52 5.84 0.3 1.22e-8 Joint mobility (Beighton score); LUSC trans rs564343 0.563 rs1642958 chr11:65821973 G/C cg26701943 chr11:108369231 KDELC2 -0.45 -6.1 -0.32 2.93e-9 Obesity (early onset extreme); LUSC cis rs897080 0.552 rs698799 chr2:44690618 C/T cg00619915 chr2:44497795 NA -0.45 -6.4 -0.33 5.15e-10 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04599533 chr3:197687209 LMLN;IQCG -0.41 -6.15 -0.32 2.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6964587 0.758 rs7798233 chr7:91500083 G/A cg17063962 chr7:91808500 NA -0.53 -7.01 -0.36 1.37e-11 Breast cancer; LUSC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.92 -0.48 1.7e-20 Glomerular filtration rate (creatinine); LUSC cis rs9457247 0.602 rs2239827 chr6:167490945 G/A cg25258033 chr6:167368657 RNASET2 0.45 6.53 0.34 2.44e-10 Crohn's disease; LUSC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg13531842 chr10:38383804 ZNF37A -0.44 -6.72 -0.35 7.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs202629 1 rs202629 chr22:41849975 C/T cg06481639 chr22:41940642 POLR3H 0.47 5.77 0.3 1.79e-8 Cannabis dependence symptom count; LUSC cis rs6964587 1.000 rs4727267 chr7:91570290 G/C cg17063962 chr7:91808500 NA -0.58 -9.19 -0.45 4.34e-18 Breast cancer; LUSC cis rs372883 0.648 rs2832297 chr21:30742996 A/C cg08807101 chr21:30365312 RNF160 0.68 11.03 0.52 2.44e-24 Pancreatic cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08862778 chr1:11322643 MTOR 0.44 6.57 0.34 1.92e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg16447950 chr5:562315 NA -0.54 -6.69 -0.34 9.26e-11 Obesity-related traits; LUSC cis rs6580649 0.883 rs4760621 chr12:48561262 A/G cg24011408 chr12:48396354 COL2A1 0.48 6.52 0.34 2.64e-10 Lung cancer; LUSC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg10523679 chr1:76189770 ACADM 0.91 14.45 0.62 4.09e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg08470875 chr2:26401718 FAM59B 0.71 9.86 0.47 2.71e-20 Gut microbiome composition (summer); LUSC cis rs859767 0.501 rs10171371 chr2:135372159 C/T cg12500956 chr2:135428796 TMEM163 -0.27 -6.47 -0.33 3.56e-10 Neuroticism; LUSC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg09021430 chr5:549028 NA -0.55 -7.25 -0.37 2.95e-12 Lung disease severity in cystic fibrosis; LUSC cis rs1670533 0.932 rs2045067 chr4:1052355 C/T cg16405210 chr4:1374714 KIAA1530 -0.47 -5.86 -0.31 1.11e-8 Recombination rate (females); LUSC cis rs12421382 0.659 rs2028337 chr11:109380887 G/C cg16359550 chr11:109292809 C11orf87 0.35 6.05 0.31 3.96e-9 Schizophrenia; LUSC cis rs16958440 0.708 rs62096465 chr18:44629624 C/T cg17192377 chr18:44677553 HDHD2 0.43 5.67 0.3 3.02e-8 Sitting height ratio; LUSC cis rs721399 0.539 rs7460653 chr8:18266983 G/C cg18736775 chr8:18248649 NAT2 -0.6 -7.09 -0.36 7.9e-12 Blood metabolite levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22468868 chr17:58042029 RNFT1 -0.43 -6.18 -0.32 1.88e-9 Electrocardiographic conduction measures; LUSC cis rs12049351 0.774 rs12125978 chr1:229627722 T/C cg11742688 chr1:229674241 ABCB10 -0.4 -5.68 -0.3 2.96e-8 Circulating myeloperoxidase levels (plasma); LUSC cis rs9486719 0.857 rs6568392 chr6:96861476 G/T cg06623918 chr6:96969491 KIAA0776 0.79 11.43 0.53 9.64e-26 Migraine;Coronary artery disease; LUSC cis rs62400317 0.893 rs62436782 chr6:45143118 T/A cg20913747 chr6:44695427 NA -0.46 -7.43 -0.38 8.91e-13 Total body bone mineral density; LUSC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.91 0.35 2.53e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg15857475 chr8:145742913 RECQL4;LRRC14 -0.77 -13.83 -0.6 1.09e-34 Age at first birth; LUSC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg08847533 chr14:75593920 NEK9 -0.66 -10.75 -0.51 2.37e-23 Coronary artery disease; LUSC cis rs4766646 0.524 rs6606743 chr12:110279179 A/G cg10794374 chr12:110278745 NA 0.31 7.0 0.36 1.44e-11 Metabolite levels (MHPG); LUSC cis rs6835098 1.000 rs28477433 chr4:174085820 T/C cg08422745 chr4:174089978 GALNT7 -0.85 -13.98 -0.61 2.67e-35 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs34421088 0.560 rs2618434 chr8:11398865 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.96 -0.31 6.29e-9 Neuroticism; LUSC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg00484396 chr16:3507460 NAT15 -0.71 -9.25 -0.45 2.72e-18 Tuberculosis; LUSC cis rs6977660 1.000 rs7779902 chr7:19803491 G/A cg07541023 chr7:19748670 TWISTNB 0.53 6.14 0.32 2.4e-9 Thyroid stimulating hormone; LUSC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg10664184 chr19:17420304 DDA1 0.5 6.4 0.33 5.28e-10 Systemic lupus erythematosus; LUSC cis rs66573146 1.000 rs6838250 chr4:6973184 C/G cg00086871 chr4:6988644 TBC1D14 1.05 8.99 0.44 1.84e-17 Granulocyte percentage of myeloid white cells; LUSC cis rs72781680 0.716 rs2712065 chr2:23973603 C/T cg08917208 chr2:24149416 ATAD2B -0.52 -6.01 -0.31 4.74e-9 Lymphocyte counts; LUSC cis rs708547 0.581 rs10020462 chr4:57825593 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.5 -7.41 -0.38 1.04e-12 Response to bleomycin (chromatid breaks); LUSC cis rs7639513 0.767 rs7648488 chr3:12708946 T/C cg23032965 chr3:12705835 RAF1 0.76 11.48 0.53 6.24e-26 Itch intensity from mosquito bite; LUSC trans rs4332037 0.539 rs57148375 chr7:2025001 G/C cg11693508 chr17:37793320 STARD3 0.59 7.08 0.36 8.53e-12 Bipolar disorder; LUSC cis rs4631830 0.900 rs10763576 chr10:51538813 A/T cg20129853 chr10:51489980 NA -0.33 -6.61 -0.34 1.55e-10 Prostate-specific antigen levels; LUSC cis rs672059 1.000 rs547905 chr1:183157924 G/A ch.1.3577855R chr1:183094577 LAMC1 0.54 7.83 0.39 6.6e-14 Hypertriglyceridemia; LUSC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg06618935 chr21:46677482 NA -0.41 -8.11 -0.41 9.97e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg22349387 chr12:9600060 DDX12 -0.42 -7.0 -0.36 1.45e-11 Breast size; LUSC cis rs9952991 0.883 rs2847260 chr18:12775591 C/T cg23544223 chr18:12777786 NA 0.59 6.25 0.32 1.26e-9 Inflammatory skin disease; LUSC cis rs6665290 0.558 rs1319103 chr1:227219314 A/G cg10327440 chr1:227177885 CDC42BPA -0.85 -14.26 -0.62 2.35e-36 Myeloid white cell count; LUSC cis rs4474465 0.736 rs10899550 chr11:78256078 G/A cg27205649 chr11:78285834 NARS2 0.52 6.2 0.32 1.7e-9 Alzheimer's disease (survival time); LUSC cis rs10761482 0.861 rs4520549 chr10:62104516 C/T cg18175470 chr10:62150864 ANK3 -0.48 -6.91 -0.35 2.51e-11 Schizophrenia; LUSC cis rs921968 0.519 rs72966020 chr2:219642620 C/G cg02176678 chr2:219576539 TTLL4 -0.71 -13.63 -0.6 6.11e-34 Mean corpuscular hemoglobin concentration; LUSC cis rs1568889 0.838 rs3812738 chr11:28129982 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.71 0.57 1.93e-30 Bipolar disorder; LUSC cis rs10100465 0.961 rs10093382 chr8:118640159 C/T cg09430518 chr8:118662568 NA 0.32 6.09 0.32 3.15e-9 Leprosy; LUSC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg27432699 chr2:27873401 GPN1 -0.56 -8.4 -0.42 1.34e-15 Total body bone mineral density; LUSC cis rs748404 0.697 rs473554 chr15:43568207 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.57 8.93 0.44 2.89e-17 Lung cancer; LUSC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg06640241 chr16:89574553 SPG7 -0.62 -9.32 -0.45 1.69e-18 Multiple myeloma (IgH translocation); LUSC cis rs977987 0.806 rs7202596 chr16:75491072 G/T cg03315344 chr16:75512273 CHST6 0.49 9.39 0.46 9.82e-19 Dupuytren's disease; LUSC cis rs1395 0.571 rs114507490 chr2:27527246 T/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 6.51 0.34 2.76e-10 Blood metabolite levels; LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs2282032 0.527 rs41309248 chr14:90767386 C/T cg14092571 chr14:90743983 NA 0.48 8.01 0.4 1.95e-14 Longevity; LUSC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg18876405 chr7:65276391 NA -0.58 -9.51 -0.46 4.03e-19 Aortic root size; LUSC cis rs11264213 0.901 rs72661640 chr1:36447232 T/G cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.33e-14 Schizophrenia; LUSC cis rs6546537 0.550 rs4241252 chr2:69777065 C/A cg10773587 chr2:69614142 GFPT1 -0.42 -6.54 -0.34 2.27e-10 Serum thyroid-stimulating hormone levels; LUSC cis rs1728785 0.901 rs1645974 chr16:68564774 C/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.6 0.54 2.33e-26 Prudent dietary pattern; LUSC cis rs7927592 0.513 rs689075 chr11:68194432 A/C cg20283391 chr11:68216788 NA -0.5 -7.03 -0.36 1.18e-11 Total body bone mineral density; LUSC cis rs7089973 0.836 rs12765350 chr10:116635305 G/A cg23260525 chr10:116636907 FAM160B1 0.39 7.99 0.4 2.19e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.81 -0.3 1.44e-8 Alzheimer's disease (late onset); LUSC cis rs5758659 0.967 rs5751250 chr22:42639645 T/G cg15557168 chr22:42548783 NA -0.43 -7.23 -0.37 3.41e-12 Cognitive function; LUSC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg22834771 chr12:69754056 YEATS4 -0.42 -6.03 -0.31 4.36e-9 Blood protein levels; LUSC cis rs2832077 0.506 rs2832093 chr21:30164855 C/T cg24692254 chr21:30365293 RNF160 -0.53 -7.13 -0.36 6.2e-12 Cognitive test performance; LUSC cis rs68170813 0.559 rs17427158 chr7:106824259 G/T cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.86e-20 Coronary artery disease; LUSC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg26061582 chr7:22766209 IL6 0.48 7.22 0.37 3.56e-12 Lung cancer; LUSC cis rs7937682 0.924 rs7924683 chr11:111555796 C/A cg22437258 chr11:111473054 SIK2 0.54 7.3 0.37 2.1e-12 Primary sclerosing cholangitis; LUSC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.75 0.35 6.47e-11 Tonsillectomy; LUSC trans rs208520 0.690 rs1563929 chr6:66702108 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 16.66 0.67 8.82e-46 Exhaled nitric oxide output; LUSC cis rs2816062 0.775 rs2816046 chr1:18893708 A/G cg18795169 chr1:18902165 NA -0.97 -22.69 -0.78 1.31e-69 Urate levels in lean individuals; LUSC cis rs1559088 1.000 rs7260051 chr19:33550111 C/A cg17764715 chr19:33622953 WDR88 0.58 7.82 0.39 6.92e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7215564 0.822 rs2340769 chr17:78755271 C/T cg06153925 chr17:78755379 RPTOR -0.38 -5.75 -0.3 2e-8 Myopia (pathological); LUSC cis rs9486715 0.867 rs926277 chr6:96868837 T/A cg06623918 chr6:96969491 KIAA0776 0.93 17.56 0.69 2.32e-49 Headache; LUSC cis rs478304 0.651 rs4014195 chr11:65506822 C/G cg10518572 chr11:65560635 OVOL1 0.25 5.92 0.31 8.17e-9 Acne (severe); LUSC cis rs4499344 0.556 rs259236 chr19:33116122 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 1.0 14.2 0.61 3.87e-36 Mean platelet volume; LUSC cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg17892150 chr10:133769511 PPP2R2D -0.65 -9.14 -0.45 6.15e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg15335139 chr3:50242325 SLC38A3 -0.27 -5.86 -0.31 1.11e-8 Body mass index; LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.71 0.3 2.54e-8 Menopause (age at onset); LUSC cis rs11792861 0.926 rs17729523 chr9:111773317 T/C cg13535736 chr9:111863775 C9orf5 -0.43 -6.89 -0.35 2.82e-11 Menarche (age at onset); LUSC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg03289416 chr15:75166202 SCAMP2 -0.45 -7.11 -0.36 7.22e-12 Breast cancer; LUSC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg04369109 chr6:150039330 LATS1 -0.51 -7.66 -0.39 1.97e-13 Lung cancer; LUSC cis rs11168618 1.000 rs3961921 chr12:48943499 G/A cg24011408 chr12:48396354 COL2A1 0.41 6.53 0.34 2.51e-10 Adiponectin levels; LUSC cis rs1595825 0.891 rs3851979 chr2:198707638 A/T cg10547527 chr2:198650123 BOLL 0.49 5.82 0.3 1.35e-8 Ulcerative colitis; LUSC cis rs2836633 0.895 rs991816 chr21:40042150 C/A cg05519781 chr21:40033154 ERG 0.77 13.04 0.58 1.09e-31 Coronary artery disease; LUSC trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg11887960 chr12:57824829 NA 0.58 7.13 0.36 6.16e-12 Lung disease severity in cystic fibrosis; LUSC cis rs7746199 0.736 rs67652222 chr6:27586220 C/T cg26958806 chr6:27640298 NA 0.76 6.21 0.32 1.54e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg09877947 chr5:131593287 PDLIM4 0.49 8.01 0.4 1.92e-14 Breast cancer; LUSC cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC trans rs8002861 0.641 rs2325085 chr13:44410060 G/A cg12856521 chr11:46389249 DGKZ 0.44 6.43 0.33 4.53e-10 Leprosy; LUSC cis rs9325144 0.560 rs10506127 chr12:39126686 C/G cg13010199 chr12:38710504 ALG10B -0.48 -7.84 -0.39 6.24e-14 Morning vs. evening chronotype; LUSC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg14668632 chr7:2872130 GNA12 -0.45 -6.81 -0.35 4.45e-11 Height; LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg23161317 chr6:28129485 ZNF389 0.44 5.67 0.3 3.05e-8 Parkinson's disease; LUSC cis rs5769765 0.913 rs28670284 chr22:50221973 C/T cg02269571 chr22:50332266 NA -0.59 -8.38 -0.42 1.47e-15 Schizophrenia; LUSC cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg15556689 chr8:8085844 FLJ10661 0.63 9.62 0.47 1.7e-19 Mood instability; LUSC cis rs9527 0.615 rs7080462 chr10:104736699 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.55 0.46 2.83e-19 Arsenic metabolism; LUSC cis rs35771425 0.600 rs1020336 chr1:211661016 C/T cg10512769 chr1:211675356 NA -0.28 -6.51 -0.34 2.74e-10 Educational attainment (years of education); LUSC cis rs63406760 1 rs63406760 chr12:123742692 TG/T cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.36 -0.33 6.57e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs8002861 0.935 rs1811464 chr13:44469290 T/G cg12856521 chr11:46389249 DGKZ 0.39 6.13 0.32 2.44e-9 Leprosy; LUSC cis rs977987 0.843 rs12443834 chr16:75438469 C/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.79e-10 Dupuytren's disease; LUSC cis rs7186831 1 rs7186831 chr16:75473155 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.11 -0.36 6.95e-12 Chronic obstructive pulmonary disease; LUSC cis rs713477 0.967 rs12431542 chr14:55913078 T/C cg13175173 chr14:55914753 NA -0.31 -6.5 -0.34 2.9e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs908922 0.676 rs1856119 chr1:152512483 A/G cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs897984 0.683 rs729482 chr16:31016970 T/C cg02466173 chr16:30829666 NA -0.53 -9.78 -0.47 5.15e-20 Dementia with Lewy bodies; LUSC cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg05283184 chr6:79620031 NA 0.55 11.78 0.54 4.89e-27 Intelligence (multi-trait analysis); LUSC cis rs58785573 0.504 rs62294474 chr4:38628725 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.53 7.79 0.39 8.62e-14 Lymphocyte percentage of white cells; LUSC cis rs12421382 0.659 rs979603 chr11:109384996 A/G cg27471124 chr11:109292789 C11orf87 -0.37 -6.55 -0.34 2.11e-10 Schizophrenia; LUSC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg19774624 chr17:42201019 HDAC5 0.82 14.3 0.62 1.55e-36 Total body bone mineral density; LUSC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg04362960 chr10:104952993 NT5C2 0.58 9.13 0.45 6.77e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg25258033 chr6:167368657 RNASET2 0.39 6.37 0.33 6.11e-10 Crohn's disease; LUSC trans rs72674100 0.881 rs10016957 chr4:97989074 T/C cg09670535 chr1:18959427 PAX7 -0.62 -6.34 -0.33 7.58e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg00074818 chr8:8560427 CLDN23 0.57 9.76 0.47 5.63e-20 Obesity-related traits; LUSC cis rs2247341 1.000 rs3958122 chr4:1693931 C/T cg07465881 chr4:1713556 SLBP -0.39 -5.92 -0.31 8.21e-9 Hip circumference adjusted for BMI;Height; LUSC trans rs6601855 1.000 rs6601855 chr10:4725340 C/T cg04072323 chr2:229046325 SPHKAP -0.37 -6.31 -0.33 9.04e-10 Major depressive disorder; LUSC cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg12386194 chr3:101231763 SENP7 0.53 7.46 0.38 7.33e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg00310523 chr12:86230176 RASSF9 0.45 8.31 0.41 2.43e-15 Major depressive disorder; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18404041 chr3:52824283 ITIH1 -0.52 -9.84 -0.47 3.16e-20 Bipolar disorder; LUSC cis rs939658 0.805 rs11638625 chr15:79434787 T/G cg17916960 chr15:79447300 NA -0.52 -10.41 -0.49 3.78e-22 Refractive error; LUSC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg26408565 chr15:76604113 ETFA -0.5 -8.03 -0.4 1.68e-14 Blood metabolite levels; LUSC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg06850241 chr22:41845214 NA 0.33 6.19 0.32 1.79e-9 Vitiligo; LUSC cis rs2970818 0.831 rs11063188 chr12:4588230 A/G cg11146114 chr12:4671731 NA -0.6 -5.69 -0.3 2.83e-8 Phosphorus levels; LUSC cis rs9324022 0.929 rs59488041 chr14:101180041 T/A cg18089426 chr14:101175970 NA 0.46 5.78 0.3 1.73e-8 Plateletcrit; LUSC trans rs7043095 1.000 rs7043095 chr9:91604005 A/G cg07663813 chr8:81785835 ZNF704 0.41 5.97 0.31 5.91e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs11098499 1.000 rs6837898 chr4:120179154 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.18 0.32 1.88e-9 Corneal astigmatism; LUSC cis rs372883 0.935 rs10460703 chr21:30623109 C/T cg08807101 chr21:30365312 RNF160 -0.4 -5.68 -0.3 2.9e-8 Pancreatic cancer; LUSC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg11062466 chr8:58055876 NA 0.51 6.51 0.34 2.84e-10 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg16325326 chr1:53192061 ZYG11B 0.83 14.74 0.63 3.23e-38 Monocyte count; LUSC cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg25809561 chr17:30822961 MYO1D -0.35 -5.79 -0.3 1.62e-8 Schizophrenia; LUSC cis rs11190604 1.000 rs10883508 chr10:102294413 G/A cg07080220 chr10:102295463 HIF1AN 0.7 9.43 0.46 7.11e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg20608306 chr11:116969690 SIK3 0.41 6.8 0.35 4.85e-11 Blood protein levels; LUSC cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.77 0.57 1.11e-30 Chronic sinus infection; LUSC cis rs1018836 0.892 rs1476428 chr8:91555603 G/T cg16814680 chr8:91681699 NA -0.68 -10.79 -0.51 1.78e-23 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs11971779 0.680 rs11772026 chr7:139052589 T/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.56 0.38 4e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs975739 0.868 rs5351 chr13:78475313 C/T cg14966220 chr13:46626929 ZC3H13 -0.38 -6.35 -0.33 7.11e-10 Hair color; LUSC cis rs9393692 0.645 rs766407 chr6:26319534 T/C cg13736514 chr6:26305472 NA -0.54 -10.51 -0.5 1.6e-22 Educational attainment; LUSC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg04455712 chr21:45112962 RRP1B 0.46 8.71 0.43 1.39e-16 Mean corpuscular volume; LUSC cis rs7605827 0.930 rs11675805 chr2:15578274 C/T cg19274914 chr2:15703543 NA 0.47 8.88 0.44 4.19e-17 Educational attainment (years of education); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18815006 chr10:71906516 TYSND1 -0.46 -6.16 -0.32 2.11e-9 Hepatitis; LUSC cis rs2816062 0.813 rs2816050 chr1:18894432 A/G cg18795169 chr1:18902165 NA -1.01 -24.29 -0.8 8.47e-76 Urate levels in lean individuals; LUSC cis rs6547741 0.752 rs7562863 chr2:27892694 T/A cg12559939 chr2:27858050 GPN1 -0.39 -6.07 -0.31 3.56e-9 Oral cavity cancer; LUSC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg27494647 chr7:150038898 RARRES2 0.46 6.91 0.35 2.52e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs8060686 0.545 rs75229939 chr16:68164949 G/A cg09835421 chr16:68378352 PRMT7 -0.61 -6.38 -0.33 5.77e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg26384229 chr12:38710491 ALG10B 0.95 18.29 0.71 2.94e-52 Heart rate; LUSC cis rs7904368 0.806 rs7087360 chr10:16872337 C/A cg14835575 chr10:16859367 RSU1 0.71 9.16 0.45 5.29e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs10911251 0.546 rs944971 chr1:183112505 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg26314531 chr2:26401878 FAM59B -0.7 -9.71 -0.47 8.31e-20 Gut microbiome composition (summer); LUSC cis rs7618501 0.722 rs9853458 chr3:49783211 A/C cg24110177 chr3:50126178 RBM5 0.43 6.83 0.35 4.05e-11 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.82 0.6 1.14e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg00024416 chr22:24240387 NA -0.33 -5.69 -0.3 2.81e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs17685 0.753 rs8200 chr7:75696606 C/G cg19862616 chr7:65841803 NCRNA00174 -1.1 -19.28 -0.73 3.33e-56 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs977987 0.966 rs8055490 chr16:75497135 C/T cg03315344 chr16:75512273 CHST6 0.54 10.49 0.5 1.91e-22 Dupuytren's disease; LUSC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg13683864 chr3:40499215 RPL14 -1.11 -21.91 -0.77 1.37e-66 Renal cell carcinoma; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs4629180 1.000 rs59246268 chr2:102089021 G/A cg04415270 chr2:102091202 RFX8 -0.54 -8.66 -0.43 2e-16 Chronic rhinosinusitis with nasal polyps; LUSC trans rs17685 0.725 rs7795291 chr7:75725206 C/A cg19862616 chr7:65841803 NCRNA00174 1.11 19.03 0.72 3.14e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1775715 0.674 rs2778670 chr10:32161676 G/A cg18675610 chr10:32216311 ARHGAP12 0.3 6.59 0.34 1.68e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12137294 0.829 rs1172154 chr1:205220639 T/G cg21643547 chr1:205240462 TMCC2 -0.35 -6.4 -0.33 5.2e-10 Red cell distribution width; LUSC cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg08085267 chr17:45401833 C17orf57 0.61 10.24 0.49 1.44e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2479724 0.846 rs2254474 chr6:41843044 T/G cg17623882 chr6:41773611 USP49 -0.61 -10.35 -0.49 5.92e-22 Menarche (age at onset); LUSC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2932538 0.885 rs7516421 chr1:113089696 T/C cg22162597 chr1:113214053 CAPZA1 0.54 7.8 0.39 7.9e-14 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs1864729 1.000 rs2451113 chr8:98273448 G/A cg08679828 chr8:102218111 ZNF706 -0.79 -7.19 -0.37 4.25e-12 Estradiol plasma levels (breast cancer); LUSC cis rs9303401 0.659 rs7216648 chr17:56790858 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg16606324 chr3:10149918 C3orf24 0.62 8.87 0.44 4.41e-17 Alzheimer's disease; LUSC cis rs939658 0.683 rs8038464 chr15:79463036 A/T cg17916960 chr15:79447300 NA -0.43 -7.79 -0.39 8.72e-14 Refractive error; LUSC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg11764359 chr7:65958608 NA -0.63 -9.62 -0.47 1.67e-19 Aortic root size; LUSC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg18681998 chr4:17616180 MED28 0.78 13.66 0.6 4.67e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7829975 0.902 rs777707 chr8:8584344 A/G cg27411982 chr8:10470053 RP1L1 0.38 6.01 0.31 4.91e-9 Mood instability; LUSC cis rs7903847 0.620 rs61863813 chr10:99112786 T/C cg20016023 chr10:99160130 RRP12 -0.34 -8.06 -0.4 1.35e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs11785693 0.862 rs62491200 chr8:4998001 A/C cg26367366 chr8:4980734 NA 0.77 9.01 0.44 1.58e-17 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs3812831 0.662 rs418027 chr13:114929344 A/C cg15896084 chr13:114927664 NA 0.41 7.22 0.37 3.5e-12 Schizophrenia; LUSC trans rs61931739 0.500 rs10772163 chr12:34532950 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs2204008 0.837 rs10876019 chr12:37985477 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.92 0.51 6.29e-24 Bladder cancer; LUSC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg03264133 chr6:25882463 NA 0.37 6.11 0.32 2.84e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg24829409 chr8:58192753 C8orf71 -0.53 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg00033643 chr7:134001901 SLC35B4 0.42 6.61 0.34 1.48e-10 Mean platelet volume; LUSC cis rs12410462 0.579 rs77529417 chr1:227547895 T/C cg23173402 chr1:227635558 NA 0.56 6.34 0.33 7.53e-10 Major depressive disorder; LUSC cis rs2274273 0.615 rs17672058 chr14:55673394 C/T cg04306507 chr14:55594613 LGALS3 0.47 9.24 0.45 3.04e-18 Protein biomarker; LUSC cis rs9815354 0.680 rs114478966 chr3:42007050 T/C cg03022575 chr3:42003672 ULK4 0.79 8.31 0.41 2.48e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs2204008 0.529 rs1315350 chr12:38164282 C/A cg13010199 chr12:38710504 ALG10B -0.51 -7.64 -0.39 2.31e-13 Bladder cancer; LUSC cis rs4290604 0.748 rs6431514 chr2:238051064 T/C cg23555395 chr2:238036564 NA -0.52 -6.94 -0.35 2.07e-11 Asthma; LUSC cis rs2236918 0.901 rs1635502 chr1:242039382 A/G cg17736920 chr1:242011382 EXO1 0.41 6.33 0.33 8.08e-10 Menopause (age at onset); LUSC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs2404602 0.735 rs4886805 chr15:76739384 A/G cg23625390 chr15:77176239 SCAPER 0.6 9.34 0.45 1.45e-18 Blood metabolite levels; LUSC cis rs4280164 0.887 rs11158634 chr14:24776457 C/G cg16194253 chr14:24768981 DHRS1;C14orf21 -0.6 -7.11 -0.36 7.21e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.84 -0.35 3.9e-11 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.57 0.46 2.51e-19 Bipolar disorder; LUSC cis rs6714710 0.603 rs717417 chr2:98416850 T/G cg26665480 chr2:98280029 ACTR1B 0.64 9.26 0.45 2.47e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19777998 chr3:11762192 VGLL4 0.46 6.21 0.32 1.61e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.67 -0.39 1.93e-13 Personality dimensions; LUSC trans rs2018683 0.834 rs2012754 chr7:29026257 G/A cg19402173 chr7:128379420 CALU -0.57 -9.27 -0.45 2.39e-18 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg26897989 chr16:1907736 C16orf73 -0.44 -6.86 -0.35 3.32e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs3768617 0.510 rs10797842 chr1:183081867 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.63 0.5 6.32e-23 Fuchs's corneal dystrophy; LUSC cis rs17270561 0.609 rs4712959 chr6:25727057 C/T cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg03188948 chr7:1209495 NA 0.66 7.06 0.36 9.67e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2243480 1.000 rs160655 chr7:65533214 T/C cg10756647 chr7:56101905 PSPH 0.86 8.74 0.43 1.18e-16 Diabetic kidney disease; LUSC cis rs2742417 0.603 rs6807438 chr3:45778623 G/A cg10512202 chr3:45649293 LIMD1 0.36 6.02 0.31 4.48e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2288073 0.801 rs10175668 chr2:24367275 G/A cg06627628 chr2:24431161 ITSN2 -0.68 -9.47 -0.46 5.18e-19 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs7107174 0.892 rs4945273 chr11:78096977 T/C cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs782590 0.764 rs2586970 chr2:55829967 A/G cg03859395 chr2:55845619 SMEK2 0.81 14.18 0.61 4.69e-36 Metabolic syndrome; LUSC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg03233332 chr7:66118400 NA -0.4 -5.98 -0.31 5.74e-9 Aortic root size; LUSC cis rs3820928 0.874 rs59630650 chr2:227786514 T/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.82 -0.39 7.1e-14 Pulmonary function; LUSC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.76 0.35 6.02e-11 Lung cancer; LUSC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg14784868 chr12:69753453 YEATS4 0.82 14.29 0.62 1.77e-36 Blood protein levels; LUSC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg18252515 chr7:66147081 NA -1.25 -13.99 -0.61 2.56e-35 Diabetic kidney disease; LUSC cis rs76878669 0.561 rs12416747 chr11:66135614 A/G cg18002602 chr11:66138449 SLC29A2 0.45 8.1 0.41 1.06e-14 Educational attainment (years of education); LUSC cis rs1044826 0.642 rs295482 chr3:139229264 A/T cg15131784 chr3:139108705 COPB2 -0.4 -6.42 -0.33 4.62e-10 Obesity-related traits; LUSC cis rs4843185 0.576 rs381624 chr16:85728679 G/A cg00168118 chr16:85669675 KIAA0182 0.39 6.07 0.32 3.47e-9 Platelet distribution width; LUSC cis rs34330 0.562 rs10845615 chr12:12863470 C/T cg04607235 chr12:12878440 APOLD1 -0.55 -6.43 -0.33 4.42e-10 Systemic lupus erythematosus; LUSC cis rs68170813 0.652 rs17404067 chr7:107168119 G/T cg02696742 chr7:106810147 HBP1 -0.64 -8.52 -0.42 5.51e-16 Coronary artery disease; LUSC cis rs546131 0.820 rs744841 chr11:34857667 G/A cg06937548 chr11:34938143 PDHX;APIP 0.49 7.06 0.36 9.43e-12 Lung disease severity in cystic fibrosis; LUSC cis rs2857891 0.695 rs1907609 chr11:6991389 G/A cg04053776 chr11:6947353 ZNF215 0.42 6.15 0.32 2.21e-9 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11644478 chr21:40555479 PSMG1 0.9 16.3 0.67 2.39e-44 Cognitive function; LUSC cis rs1448094 0.967 rs7312144 chr12:86328256 T/C cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.31e-9 Major depressive disorder; LUSC cis rs7605827 0.930 rs1997304 chr2:15512073 G/T cg19274914 chr2:15703543 NA 0.46 8.94 0.44 2.66e-17 Educational attainment (years of education); LUSC cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.74 -0.3 2.08e-8 Bipolar disorder; LUSC cis rs7188861 0.681 rs34294744 chr16:11407623 C/G cg00044050 chr16:11439710 C16orf75 0.58 5.94 0.31 7.03e-9 HDL cholesterol; LUSC cis rs9818758 0.607 rs67060340 chr3:48915321 C/T cg00383909 chr3:49044727 WDR6 1.27 11.7 0.54 9.84e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg12463550 chr7:65579703 CRCP -0.53 -7.64 -0.39 2.37e-13 Aortic root size; LUSC cis rs4595586 0.545 rs925829 chr12:39364167 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg24675658 chr1:53192096 ZYG11B -0.63 -9.86 -0.47 2.69e-20 Monocyte count; LUSC cis rs926938 0.584 rs360607 chr1:115392401 C/A cg01522456 chr1:115632236 TSPAN2 -0.41 -6.53 -0.34 2.51e-10 Autism; LUSC cis rs11229555 0.645 rs12805062 chr11:58214584 A/G cg15696309 chr11:58395628 NA -0.64 -7.83 -0.39 6.55e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10489525 0.530 rs11102884 chr1:115612947 A/G cg01522456 chr1:115632236 TSPAN2 -0.4 -5.82 -0.3 1.41e-8 Autism; LUSC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg02038168 chr22:39784481 NA -0.49 -7.96 -0.4 2.72e-14 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.820 rs28394116 chr4:120524283 T/G cg09307838 chr4:120376055 NA 0.69 10.25 0.49 1.3e-21 Corneal astigmatism; LUSC trans rs931812 1.000 rs931812 chr8:101919321 A/G cg20993868 chr7:22813445 NA -0.57 -10.47 -0.5 2.19e-22 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs2464469 0.631 rs2704218 chr15:58345001 A/T cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.9 -0.31 8.9e-9 Barrett's esophagus or Esophageal adenocarcinoma; LUSC cis rs11168618 0.967 rs10875831 chr12:48938380 G/A cg24011408 chr12:48396354 COL2A1 0.39 6.32 0.33 8.21e-10 Adiponectin levels; LUSC cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 2e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12421382 0.614 rs12418827 chr11:109390649 G/C cg27471124 chr11:109292789 C11orf87 0.37 6.74 0.35 6.83e-11 Schizophrenia; LUSC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.55 7.65 0.39 2.23e-13 Tuberculosis; LUSC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.98 -0.36 1.57e-11 Lung cancer; LUSC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs68092024 0.704 rs792832 chr3:99474862 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -7.27 -0.37 2.59e-12 Cleft lip with or without cleft palate; LUSC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.08 0.48 4.91e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9329289 0.510 rs2029604 chr10:2554700 T/C cg15501526 chr10:2543763 NA 0.53 9.3 0.45 1.89e-18 Age-related hearing impairment; LUSC cis rs977987 0.835 rs3851733 chr16:75370263 G/C cg03315344 chr16:75512273 CHST6 0.53 10.15 0.49 2.93e-21 Dupuytren's disease; LUSC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg01849466 chr14:104193079 ZFYVE21 -0.55 -7.88 -0.4 4.53e-14 Reticulocyte count; LUSC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg01097406 chr16:89675127 NA 0.46 9.54 0.46 3.02e-19 Vitiligo; LUSC trans rs6951245 0.554 rs76243429 chr7:1152543 C/T cg13565492 chr6:43139072 SRF -0.7 -10.42 -0.5 3.44e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2303282 0.716 rs2440466 chr16:56411165 A/G cg00500540 chr16:56394104 NA -0.44 -7.58 -0.38 3.53e-13 Breast cancer; LUSC cis rs2072499 0.833 rs2842870 chr1:156200671 T/C cg24450063 chr1:156163899 SLC25A44 1.1 22.68 0.78 1.37e-69 Testicular germ cell tumor; LUSC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg21724239 chr8:58056113 NA 0.56 6.92 0.35 2.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg06634786 chr22:41940651 POLR3H -0.57 -6.59 -0.34 1.71e-10 Vitiligo; LUSC cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.45 -6.7 -0.34 8.97e-11 Schizophrenia; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg26338869 chr17:61819248 STRADA 0.42 6.17 0.32 1.92e-9 Prudent dietary pattern; LUSC cis rs977987 0.705 rs4888377 chr16:75325686 C/G cg04384234 chr16:75411784 CFDP1 -0.45 -7.1 -0.36 7.75e-12 Dupuytren's disease; LUSC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg07701084 chr6:150067640 NUP43 0.54 8.08 0.4 1.21e-14 Lung cancer; LUSC cis rs9303401 0.659 rs35928756 chr17:56702652 C/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.67 0.43 1.92e-16 Cognitive test performance; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07627390 chr16:23652638 PALB2;DCTN5 -0.42 -6.99 -0.36 1.49e-11 Electrocardiographic conduction measures; LUSC cis rs9303401 0.614 rs62084384 chr17:57126842 G/A cg25039879 chr17:56429692 SUPT4H1 0.69 9.06 0.44 1.12e-17 Cognitive test performance; LUSC cis rs1997103 1.000 rs10279035 chr7:55412055 C/T cg17469321 chr7:55412551 NA 0.64 10.19 0.49 2.02e-21 QRS interval (sulfonylurea treatment interaction); LUSC trans rs931812 0.825 rs6993937 chr8:101898707 A/G cg20993868 chr7:22813445 NA 0.61 10.89 0.51 7.97e-24 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs2124969 0.548 rs72982036 chr2:161031590 G/A cg03641300 chr2:160917029 PLA2R1 -0.46 -5.69 -0.3 2.84e-8 Waist circumference adjusted for body mass index; LUSC cis rs12701220 0.803 rs12701432 chr7:1052453 C/T cg26769984 chr7:1090371 C7orf50 0.69 9.94 0.48 1.43e-20 Bronchopulmonary dysplasia; LUSC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg26818010 chr10:134567672 INPP5A -0.83 -10.57 -0.5 1.04e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs554111 0.613 rs3816455 chr1:21191430 A/G cg01072550 chr1:21505969 NA 0.41 6.29 0.33 1.01e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC trans rs6502050 0.777 rs4625783 chr17:80086395 T/C cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.34e-10 Life satisfaction; LUSC cis rs2147959 0.941 rs1007686 chr1:228651457 A/G cg18477163 chr1:228402036 OBSCN -0.43 -5.97 -0.31 6.22e-9 Adult asthma; LUSC cis rs710216 0.763 rs841857 chr1:43400016 C/T cg22176566 chr1:43424700 SLC2A1 0.49 6.02 0.31 4.67e-9 Red cell distribution width; LUSC cis rs1572438 1.000 rs9379167 chr6:866372 C/T cg13447295 chr6:887704 NA -0.38 -5.65 -0.3 3.43e-8 Aging; LUSC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg22508957 chr16:3507546 NAT15 0.41 6.58 0.34 1.8e-10 Body mass index (adult); LUSC cis rs7828089 0.504 rs12676477 chr8:22266425 T/C cg12081754 chr8:22256438 SLC39A14 0.76 11.87 0.54 2.28e-27 Verbal declarative memory; LUSC cis rs10761482 0.768 rs3919830 chr10:62108205 T/C cg18175470 chr10:62150864 ANK3 -0.51 -7.31 -0.37 2e-12 Schizophrenia; LUSC cis rs11608355 0.521 rs4766469 chr12:109836890 C/G cg19025524 chr12:109796872 NA 0.4 7.4 0.38 1.11e-12 Neuroticism; LUSC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg23758822 chr17:41437982 NA 1.01 19.97 0.74 5.81e-59 Menopause (age at onset); LUSC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg23262073 chr20:60523788 NA -0.36 -5.74 -0.3 2.18e-8 Body mass index; LUSC cis rs10865541 0.934 rs4627605 chr2:3411923 G/A cg15807143 chr2:3452624 TTC15 0.34 5.91 0.31 8.31e-9 Obesity-related traits; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg15704280 chr7:45808275 SEPT13 -1.01 -17.03 -0.68 2.87e-47 Coronary artery disease; LUSC cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs8064299 0.655 rs895691 chr17:72766300 G/T cg25054828 chr17:72772726 NAT9;TMEM104 0.56 9.41 0.46 8.55e-19 Monocyte count; LUSC cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg22681709 chr2:178499509 PDE11A -0.49 -9.08 -0.45 9.43e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10504073 0.647 rs62507246 chr8:50013449 G/A cg00325661 chr8:49890786 NA 0.62 10.04 0.48 6.47e-21 Blood metabolite ratios; LUSC cis rs2274273 0.840 rs10150760 chr14:55821548 C/T cg04306507 chr14:55594613 LGALS3 -0.53 -11.65 -0.54 1.47e-26 Protein biomarker; LUSC cis rs7789940 0.951 rs7787526 chr7:75947553 C/T cg15798862 chr7:76129360 DTX2 -0.47 -7.68 -0.39 1.77e-13 Multiple sclerosis; LUSC cis rs2742234 0.541 rs12220534 chr10:43734306 G/T cg15436174 chr10:43711423 RASGEF1A -0.38 -6.65 -0.34 1.18e-10 Hirschsprung disease; LUSC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 8.65 0.43 2.23e-16 Height; LUSC cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg23158103 chr7:148848205 ZNF398 -0.5 -8.06 -0.4 1.38e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs629535 0.859 rs55803226 chr8:70108965 T/C cg21567404 chr3:27674614 NA -0.96 -15.51 -0.65 2.94e-41 Dupuytren's disease; LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg26314531 chr2:26401878 FAM59B 0.74 10.06 0.48 5.92e-21 Gut microbiome composition (summer); LUSC cis rs13040088 1.000 rs13040088 chr20:61549202 A/G cg23096297 chr20:61557774 DIDO1 0.75 9.62 0.47 1.64e-19 Menopause (age at onset); LUSC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg06636001 chr8:8085503 FLJ10661 -0.61 -9.57 -0.46 2.49e-19 Mood instability; LUSC cis rs12579753 0.913 rs7965664 chr12:82237340 G/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.01 -0.31 4.82e-9 Resting heart rate; LUSC cis rs4953076 0.573 rs6734443 chr2:44408282 G/C cg04920474 chr2:44395004 PPM1B 0.65 8.35 0.42 1.9e-15 Height; LUSC cis rs7267979 0.932 rs6115200 chr20:25487377 G/T cg03522245 chr20:25566470 NINL 0.36 5.89 0.31 9.51e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs16854884 0.837 rs6804060 chr3:143804040 C/T cg06585982 chr3:143692056 C3orf58 0.43 6.17 0.32 2.01e-9 Economic and political preferences (feminism/equality); LUSC cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg01802117 chr1:53393560 SCP2 0.39 6.46 0.33 3.72e-10 Monocyte count; LUSC cis rs8060686 0.641 rs75297764 chr16:68212820 C/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs422249 0.634 rs174609 chr11:61627811 T/C cg06860612 chr11:61641270 FADS3 0.28 5.84 0.3 1.22e-8 Trans fatty acid levels; LUSC cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.03 0.48 7.06e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs9811920 0.715 rs6776886 chr3:99906270 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.32 6.11 0.32 2.72e-9 Axial length; LUSC cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.74 -0.43 1.17e-16 Monocyte percentage of white cells; LUSC cis rs76419734 0.510 rs2553463 chr4:106730663 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.52 -5.84 -0.3 1.27e-8 Post bronchodilator FEV1; LUSC cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg06618935 chr21:46677482 NA -0.39 -8.02 -0.4 1.84e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20482337 chr12:104324290 LOC253724;HSP90B1 0.4 5.94 0.31 7.06e-9 Triglycerides; LUSC cis rs7512552 0.839 rs11587575 chr1:150451863 T/C cg15654264 chr1:150340011 RPRD2 0.62 10.31 0.49 8.23e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1784581 0.532 rs7767219 chr6:162423088 T/C cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.05e-20 Itch intensity from mosquito bite; LUSC cis rs6456156 0.565 rs12525345 chr6:167478875 T/C cg06454157 chr6:167490870 NA -0.28 -6.67 -0.34 1.08e-10 Primary biliary cholangitis; LUSC cis rs7903847 0.642 rs7896100 chr10:99156994 C/T cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs3087591 0.920 rs4795592 chr17:29612620 C/G cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.13 -0.41 8.66e-15 Hip circumference; LUSC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg24209194 chr3:40518798 ZNF619 0.45 6.0 0.31 5.1e-9 Renal cell carcinoma; LUSC trans rs1908814 0.516 rs4840597 chr8:11796068 A/C cg08975724 chr8:8085496 FLJ10661 0.48 6.91 0.35 2.49e-11 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26251429 chr2:28113398 BRE;RBKS;LOC100302650 -0.48 -6.46 -0.33 3.78e-10 Bipolar disorder and schizophrenia; LUSC cis rs10189230 0.868 rs1367242 chr2:222353441 A/G cg14652038 chr2:222343519 EPHA4 0.32 5.73 0.3 2.29e-8 Urate levels in lean individuals; LUSC cis rs2361718 0.590 rs4527052 chr17:78140910 A/G cg21238619 chr17:78079768 GAA -0.35 -6.65 -0.34 1.23e-10 Yeast infection; LUSC cis rs546131 0.928 rs546521 chr11:34824773 G/C cg11058730 chr11:34937778 PDHX;APIP 0.44 5.91 0.31 8.4e-9 Lung disease severity in cystic fibrosis; LUSC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC cis rs6942756 1.000 rs6467233 chr7:128868656 C/T cg02491457 chr7:128862824 NA -0.56 -8.05 -0.4 1.42e-14 White matter hyperintensity burden; LUSC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.74 9.13 0.45 6.84e-18 Gut microbiome composition (summer); LUSC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg10523679 chr1:76189770 ACADM 0.89 15.49 0.65 3.73e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs617219 0.819 rs72766705 chr5:78562000 C/T cg24856658 chr5:78533917 JMY -0.32 -6.13 -0.32 2.49e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg04234412 chr22:24373322 LOC391322 0.86 14.17 0.61 4.94e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg04871131 chr7:94954202 PON1 -0.39 -6.08 -0.32 3.27e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1044826 1.000 rs4683818 chr3:139229619 G/T cg00490450 chr3:139108681 COPB2 0.53 6.91 0.35 2.51e-11 Obesity-related traits; LUSC cis rs11785693 0.862 rs13281354 chr8:4987756 G/T cg26367366 chr8:4980734 NA 0.8 9.5 0.46 4.24e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs9389248 0.737 rs12664956 chr6:135384188 T/C cg22676075 chr6:135203613 NA 0.57 8.91 0.44 3.35e-17 High light scatter reticulocyte percentage of red cells; LUSC cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg06484146 chr7:12443880 VWDE -0.62 -6.24 -0.32 1.36e-9 Coronary artery disease; LUSC cis rs68170813 0.559 rs11761181 chr7:106954879 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.55 -0.46 2.81e-19 Coronary artery disease; LUSC cis rs9549367 0.713 rs56002882 chr13:113830694 T/C cg00898013 chr13:113819073 PROZ -0.62 -8.75 -0.43 1.05e-16 Platelet distribution width; LUSC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg15445000 chr17:37608096 MED1 0.4 6.7 0.34 9.08e-11 Glomerular filtration rate (creatinine); LUSC cis rs3931020 0.745 rs1969111 chr1:75263485 A/T cg10128416 chr1:75198403 TYW3;CRYZ -0.4 -5.78 -0.3 1.68e-8 Resistin levels; LUSC cis rs9650315 0.852 rs34985835 chr8:57166158 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.07 0.36 9.07e-12 Height; LUSC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg12963246 chr6:28129442 ZNF389 0.56 7.69 0.39 1.71e-13 Depression; LUSC cis rs9399135 1.000 rs9399135 chr6:135368314 G/A cg22676075 chr6:135203613 NA 0.47 7.18 0.37 4.47e-12 Red blood cell count; LUSC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg14440974 chr22:39074834 NA -0.4 -6.54 -0.34 2.25e-10 Menopause (age at onset); LUSC trans rs11098499 0.863 rs2306456 chr4:120472422 C/G cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs4474465 0.850 rs7936232 chr11:78266602 A/G cg27205649 chr11:78285834 NARS2 0.52 6.12 0.32 2.64e-9 Alzheimer's disease (survival time); LUSC trans rs7613875 0.641 rs2624845 chr3:50062437 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -7.89 -0.4 4.24e-14 Body mass index; LUSC cis rs1178968 1.000 rs2237285 chr7:72760213 C/T cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.72e-13 Triglyceride levels; LUSC cis rs6964587 0.692 rs6953256 chr7:91575417 C/T cg17063962 chr7:91808500 NA -0.57 -9.45 -0.46 6.08e-19 Breast cancer; LUSC cis rs62064224 0.703 rs62065492 chr17:30822607 C/T cg18200150 chr17:30822561 MYO1D 0.53 10.62 0.5 6.6e-23 Schizophrenia; LUSC cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg08564027 chr20:61660810 NA 0.93 17.11 0.68 1.47e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs6693567 0.565 rs4926395 chr1:150405298 T/C cg15654264 chr1:150340011 RPRD2 0.43 6.79 0.35 5.16e-11 Migraine; LUSC cis rs7572733 0.534 rs4850813 chr2:198775982 C/T cg00792783 chr2:198669748 PLCL1 -0.45 -6.03 -0.31 4.26e-9 Dermatomyositis; LUSC cis rs7937682 0.889 rs11213969 chr11:111528441 A/G cg22437258 chr11:111473054 SIK2 0.51 6.93 0.35 2.15e-11 Primary sclerosing cholangitis; LUSC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.05 21.58 0.76 2.78e-65 Height; LUSC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg06481639 chr22:41940642 POLR3H 0.5 5.77 0.3 1.81e-8 Vitiligo; LUSC cis rs7615316 0.779 rs9289648 chr3:142036520 A/G cg16271453 chr3:142027066 XRN1 -0.4 -7.03 -0.36 1.21e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1018836 0.700 rs10504894 chr8:91516436 G/A cg16814680 chr8:91681699 NA -0.71 -11.06 -0.52 1.98e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2197308 0.740 rs10880619 chr12:37922720 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs59698941 0.550 rs60042615 chr5:132193220 A/G cg14825688 chr5:132208181 LEAP2 -0.39 -5.91 -0.31 8.65e-9 Apolipoprotein A-IV levels; LUSC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.41 -0.49 3.61e-22 Schizophrenia; LUSC cis rs9549260 0.534 rs4943810 chr13:41297405 C/A cg21288729 chr13:41239152 FOXO1 0.58 6.65 0.34 1.18e-10 Red blood cell count; LUSC cis rs453301 0.631 rs13250781 chr8:8793343 T/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.7 -0.39 1.51e-13 Joint mobility (Beighton score); LUSC cis rs10754283 0.967 rs6657988 chr1:90106745 G/C cg21401794 chr1:90099060 LRRC8C 0.65 9.74 0.47 6.91e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs72634258 0.786 rs7539807 chr1:8183789 C/T cg00042356 chr1:8021962 PARK7 0.61 7.34 0.37 1.63e-12 Inflammatory bowel disease; LUSC cis rs2708977 0.730 rs674920 chr2:97070156 C/G cg01950434 chr2:97203154 ARID5A -0.48 -6.65 -0.34 1.17e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg06022373 chr22:39101656 GTPBP1 0.83 13.64 0.6 5.66e-34 Menopause (age at onset); LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.48 5.82 0.3 1.4e-8 Renal function-related traits (BUN); LUSC cis rs2288073 0.965 rs6545340 chr2:24422269 C/G cg06627628 chr2:24431161 ITSN2 -0.78 -11.39 -0.53 1.28e-25 Venous thromboembolism (SNP x SNP interaction); LUSC trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg20587970 chr11:113659929 NA -1.27 -17.54 -0.69 2.75e-49 Hip circumference adjusted for BMI; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg04775059 chr7:64541387 NA -0.49 -7.34 -0.37 1.65e-12 Calcium levels; LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg01516881 chr6:292596 DUSP22 -0.53 -7.9 -0.4 4.11e-14 Menopause (age at onset); LUSC cis rs6920965 0.602 rs10872302 chr6:126180631 G/T cg05901451 chr6:126070800 HEY2 -0.49 -7.3 -0.37 2.17e-12 High light scatter reticulocyte count; LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.3 0.33 9.48e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7084921 0.548 rs12776483 chr10:101828600 C/A cg11888571 chr10:102027403 CWF19L1 -0.41 -5.68 -0.3 2.95e-8 Bone mineral density; LUSC cis rs2979489 0.786 rs2915595 chr8:30402817 A/G cg26383811 chr8:30366931 RBPMS 0.46 7.24 0.37 3.15e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs3925075 1.000 rs12923297 chr16:31360944 T/C cg02846316 chr16:31340340 ITGAM 0.36 6.73 0.35 7.2e-11 IgA nephropathy; LUSC cis rs11190604 1.000 rs3750627 chr10:102275642 G/T cg07080220 chr10:102295463 HIF1AN 0.68 9.17 0.45 4.81e-18 Palmitoleic acid (16:1n-7) levels; LUSC trans rs4729127 1.000 rs75903658 chr7:94006668 A/C cg20086523 chr13:52378287 DHRS12 0.62 6.76 0.35 6.13e-11 Intelligence; LUSC cis rs7937682 0.889 rs487985 chr11:111517908 G/A cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC trans rs6502050 0.835 rs34867501 chr17:80121358 T/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.71e-10 Life satisfaction; LUSC cis rs2762353 0.935 rs2328895 chr6:25802083 C/T cg12310025 chr6:25882481 NA -0.43 -7.41 -0.38 1.03e-12 Blood metabolite levels; LUSC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg24399712 chr22:39784796 NA 0.61 11.22 0.52 5.17e-25 Intelligence (multi-trait analysis); LUSC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg15704280 chr7:45808275 SEPT13 -0.51 -7.18 -0.37 4.51e-12 HDL cholesterol; LUSC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -6.26 -0.32 1.16e-9 Total body bone mineral density; LUSC cis rs367943 0.712 rs1366393 chr5:112729472 A/G cg12552261 chr5:112820674 MCC 0.37 6.23 0.32 1.42e-9 Type 2 diabetes; LUSC cis rs17125944 0.615 rs7150808 chr14:53304871 C/T cg00686598 chr14:53173677 PSMC6 -0.69 -6.02 -0.31 4.49e-9 Alzheimer's disease (late onset); LUSC cis rs7605827 0.780 rs2287279 chr2:15667778 G/A cg19274914 chr2:15703543 NA 0.46 8.9 0.44 3.59e-17 Educational attainment (years of education); LUSC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg04539111 chr16:67997858 SLC12A4 -0.47 -6.42 -0.33 4.7e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg16339924 chr4:17578868 LAP3 0.51 7.79 0.39 8.8e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1005277 0.540 rs2145487 chr10:38010077 A/G cg17830980 chr10:43048298 ZNF37B -0.4 -6.3 -0.33 9.41e-10 Extrinsic epigenetic age acceleration; LUSC cis rs427394 0.582 rs274661 chr5:6704848 C/T cg10857441 chr5:6722123 POLS -0.42 -7.73 -0.39 1.25e-13 Menopause (age at onset); LUSC cis rs4588572 0.644 rs7714871 chr5:77754268 G/T cg11547950 chr5:77652471 NA -0.48 -7.05 -0.36 1.01e-11 Triglycerides; LUSC trans rs9860340 0.730 rs1509779 chr3:87642462 A/G cg03644585 chr7:884825 UNC84A 0.42 6.04 0.31 4.05e-9 Electroencephalographic traits in alcoholism; LUSC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg10130564 chr11:117069849 TAGLN 0.37 6.37 0.33 6.42e-10 Blood protein levels; LUSC cis rs4595586 0.525 rs12818844 chr12:39423806 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.34 0.33 7.38e-10 Morning vs. evening chronotype; LUSC cis rs4843185 0.516 rs374029 chr16:85725953 G/A cg05245094 chr16:85669572 KIAA0182 0.42 6.33 0.33 7.73e-10 Platelet distribution width; LUSC cis rs3755132 0.929 rs6431716 chr2:15734621 G/A cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.68e-12 Wilms tumor; LUSC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg20243544 chr17:37824526 PNMT 0.47 5.8 0.3 1.53e-8 Urinary metabolites; LUSC cis rs3617 0.573 rs56383738 chr3:52908398 T/C cg11645453 chr3:52864694 ITIH4 -0.4 -9.26 -0.45 2.57e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs11681884 0.786 rs11887249 chr2:113809266 C/T cg19632953 chr13:113635898 MCF2L 0.69 6.03 0.31 4.45e-9 Stroke; LUSC trans rs804280 0.509 rs9886639 chr8:11784529 G/T cg15556689 chr8:8085844 FLJ10661 0.57 8.6 0.43 3.2e-16 Myopia (pathological); LUSC cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC cis rs1419980 0.673 rs10772553 chr12:7768089 G/A cg25828445 chr12:7781288 NA -0.6 -6.32 -0.33 8.31e-10 HDL cholesterol levels; LUSC cis rs7590368 1.000 rs7590368 chr2:10961474 T/C cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg05535760 chr7:792225 HEATR2 0.79 9.46 0.46 5.56e-19 Cerebrospinal P-tau181p levels; LUSC cis rs35079168 0.961 rs66475113 chr9:137284381 C/T cg13941235 chr9:137270186 RXRA -0.34 -6.08 -0.32 3.29e-9 Intelligence; LUSC cis rs7223966 1.000 rs28463311 chr17:61919643 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.49 0.33 3.11e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9467711 0.790 rs67777156 chr6:26633711 T/A cg09904177 chr6:26538194 HMGN4 -0.8 -5.92 -0.31 7.81e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg12963246 chr6:28129442 ZNF389 0.56 7.85 0.39 5.89e-14 Parkinson's disease; LUSC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 10.94 0.51 5.07e-24 Platelet count; LUSC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg16928487 chr17:17741425 SREBF1 0.47 9.32 0.45 1.68e-18 Total body bone mineral density; LUSC cis rs7712401 0.601 rs246315 chr5:122266438 C/T cg19077854 chr5:122220652 SNX24 0.42 9.36 0.46 1.18e-18 Mean platelet volume; LUSC cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg16586182 chr3:47516702 SCAP -0.52 -7.99 -0.4 2.25e-14 Colorectal cancer; LUSC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11890956 chr21:40555474 PSMG1 -0.73 -11.06 -0.52 2e-24 Menarche (age at onset); LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.72 0.47 8.01e-20 Bipolar disorder; LUSC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg23711669 chr6:146136114 FBXO30 -0.93 -17.79 -0.7 2.94e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs561341 0.883 rs2074102 chr17:30228884 G/A cg27661571 chr11:113659931 NA -0.58 -6.45 -0.33 3.9e-10 Hip circumference adjusted for BMI; LUSC cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg23583168 chr7:148888333 NA -0.81 -14.07 -0.61 1.26e-35 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs61931739 1.000 rs12305700 chr12:34036332 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.78 -0.39 8.95e-14 Morning vs. evening chronotype; LUSC cis rs8062405 0.895 rs56186137 chr16:28825953 A/G cg09754948 chr16:28834200 ATXN2L 0.44 6.48 0.33 3.35e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7759001 0.817 rs2393928 chr6:27351827 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 2.04e-8 Glomerular filtration rate (creatinine); LUSC cis rs1784581 0.569 rs9365357 chr6:162414913 A/G cg17173639 chr6:162384350 PARK2 0.57 9.95 0.48 1.32e-20 Itch intensity from mosquito bite; LUSC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg01017244 chr2:74357527 NA 0.68 12.04 0.55 5.63e-28 Gestational age at birth (maternal effect); LUSC trans rs1493916 0.655 rs4534926 chr18:31349072 G/C cg15819921 chr19:927150 ARID3A -0.43 -6.35 -0.33 7.14e-10 Life satisfaction; LUSC cis rs2658782 1.000 rs2608216 chr11:93149172 G/A cg15737290 chr11:93063684 CCDC67 0.65 8.08 0.4 1.19e-14 Pulmonary function decline; LUSC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg17173187 chr15:85201210 NMB 0.38 6.57 0.34 1.98e-10 Schizophrenia; LUSC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg01879757 chr17:41196368 BRCA1 -0.49 -7.84 -0.39 6.18e-14 Menopause (age at onset); LUSC cis rs4776059 0.959 rs12898644 chr15:52905233 A/G cg22715398 chr15:52968154 KIAA1370 -0.68 -9.99 -0.48 1.01e-20 Schizophrenia; LUSC cis rs826838 0.834 rs826874 chr12:39122599 C/A cg13010199 chr12:38710504 ALG10B -0.62 -10.23 -0.49 1.55e-21 Heart rate; LUSC cis rs7560272 0.502 rs4513320 chr2:73920741 T/C cg20560298 chr2:73613845 ALMS1 0.39 6.01 0.31 4.73e-9 Schizophrenia; LUSC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg01475377 chr6:109611718 NA 0.4 7.15 0.36 5.47e-12 Reticulocyte fraction of red cells; LUSC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.76 -0.47 5.69e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs55665837 0.961 rs12795972 chr11:14443775 C/T cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs1371867 0.846 rs2439460 chr8:101312665 C/T cg06002616 chr8:101225028 SPAG1 -0.41 -6.92 -0.35 2.32e-11 Atrioventricular conduction; LUSC cis rs243505 0.732 rs3800949 chr7:148479648 A/T cg09806900 chr7:148480153 CUL1 -0.52 -7.8 -0.39 8.1e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg06873352 chr17:61820015 STRADA 0.73 13.03 0.58 1.14e-31 Prudent dietary pattern; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg02675527 chr2:114030824 PAX8;LOC440839 0.37 5.75 0.3 2.07e-8 Lymphocyte counts; LUSC trans rs3733585 0.699 rs7658170 chr4:9966593 C/T cg26043149 chr18:55253948 FECH 0.46 7.16 0.36 5.18e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1355223 0.583 rs2941044 chr11:34867444 A/C cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.49 -0.38 6.18e-13 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.85 0.31 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs62400317 0.859 rs62438877 chr6:45089064 A/G cg18551225 chr6:44695536 NA -0.42 -6.87 -0.35 3.22e-11 Total body bone mineral density; LUSC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.5 0.53 5.42e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.82 -0.35 4.26e-11 Total body bone mineral density; LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg07395648 chr5:131743802 NA 0.39 5.71 0.3 2.55e-8 Breast cancer; LUSC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg15704280 chr7:45808275 SEPT13 -0.71 -10.66 -0.5 4.81e-23 Coronary artery disease; LUSC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg13628971 chr7:2884303 GNA12 0.5 7.14 0.36 5.82e-12 Height; LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg05165339 chr4:1420672 NA -0.3 -6.9 -0.35 2.67e-11 Longevity; LUSC cis rs3931020 0.688 rs525487 chr1:75217420 A/G cg26855724 chr1:75198818 TYW3;CRYZ -0.45 -5.66 -0.3 3.32e-8 Resistin levels; LUSC cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -7.63 -0.39 2.54e-13 Schizophrenia; LUSC cis rs6723226 0.806 rs2249109 chr2:32750879 G/A cg02381751 chr2:32503542 YIPF4 0.61 9.39 0.46 9.38e-19 Intelligence (multi-trait analysis); LUSC cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg25233709 chr10:116636983 FAM160B1 0.44 7.92 0.4 3.62e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2692947 0.644 rs3821051 chr2:96912787 A/G cg22654517 chr2:96458247 NA -0.29 -5.67 -0.3 3.11e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -11.11 -0.52 1.25e-24 Chronic sinus infection; LUSC cis rs9527 0.662 rs10786714 chr10:104598606 G/C cg23093090 chr10:104574429 C10orf26 -0.41 -6.9 -0.35 2.69e-11 Arsenic metabolism; LUSC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg00409905 chr10:38381863 ZNF37A -0.39 -6.61 -0.34 1.52e-10 Extrinsic epigenetic age acceleration; LUSC trans rs34421088 0.506 rs7813424 chr8:11144517 G/A cg06636001 chr8:8085503 FLJ10661 0.5 7.21 0.37 3.68e-12 Neuroticism; LUSC cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.91e-16 Menopause (age at onset); LUSC trans rs12165098 0.543 rs56190458 chr18:36748753 A/C cg23858286 chr9:138135095 NA -0.42 -6.18 -0.32 1.84e-9 Sleep duration; LUSC cis rs6582630 0.599 rs12309369 chr12:38419683 C/G cg26384229 chr12:38710491 ALG10B -0.55 -8.19 -0.41 5.43e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs4843747 0.671 rs9933794 chr16:88116981 T/C cg17633681 chr16:88106987 BANP 0.5 9.44 0.46 6.8e-19 Menopause (age at onset); LUSC cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg11060661 chr22:24314208 DDT;DDTL 0.5 8.08 0.4 1.17e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs78663649 0.614 rs76626935 chr19:16581375 T/C cg05286348 chr19:16641544 CHERP -1.36 -10.11 -0.48 3.96e-21 White blood cell count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03195230 chr11:64073135 ESRRA -0.39 -6.01 -0.31 4.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs698813 0.604 rs2340813 chr2:44487398 T/C cg00619915 chr2:44497795 NA -0.53 -7.55 -0.38 4.09e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs17401966 0.838 rs10492971 chr1:10342975 G/A cg19773385 chr1:10388646 KIF1B -0.5 -8.71 -0.43 1.4e-16 Hepatocellular carcinoma; LUSC cis rs6964587 1.000 rs34043009 chr7:91578447 T/C cg22117172 chr7:91764530 CYP51A1 -0.32 -5.82 -0.3 1.41e-8 Breast cancer; LUSC cis rs7772486 0.869 rs2777473 chr6:146301494 G/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.63 -0.34 1.37e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg02175503 chr12:58329896 NA 0.47 6.8 0.35 4.77e-11 Intelligence (multi-trait analysis); LUSC cis rs1943345 0.519 rs11233504 chr11:82886525 A/G cg07047830 chr11:82868014 PCF11 0.64 9.89 0.48 2.09e-20 Obesity-related traits; LUSC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg04398451 chr17:18023971 MYO15A 0.59 9.68 0.47 1.05e-19 Total body bone mineral density; LUSC cis rs4654899 0.931 rs4654726 chr1:21203898 A/C cg01072550 chr1:21505969 NA 0.5 7.55 0.38 4.25e-13 Superior frontal gyrus grey matter volume; LUSC trans rs3942852 0.910 rs10742831 chr11:48119691 G/A cg15704280 chr7:45808275 SEPT13 -0.55 -6.36 -0.33 6.83e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs7582720 1.000 rs72936846 chr2:203774734 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.38 0.42 1.49e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4622329 0.553 rs12305145 chr12:102312526 A/G cg23541617 chr12:102225335 GNPTAB 0.27 5.9 0.31 8.95e-9 Systemic lupus erythematosus; LUSC cis rs3770081 1.000 rs6724025 chr2:86200835 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -0.82 -6.24 -0.32 1.33e-9 Facial emotion recognition (sad faces); LUSC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg11764359 chr7:65958608 NA -0.7 -10.7 -0.51 3.47e-23 Aortic root size; LUSC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg05717871 chr11:638507 DRD4 -0.36 -6.09 -0.32 3.18e-9 Systemic lupus erythematosus; LUSC cis rs2236918 0.622 rs1776177 chr1:242012149 C/T cg17736920 chr1:242011382 EXO1 0.42 6.62 0.34 1.4e-10 Menopause (age at onset); LUSC cis rs9359856 0.564 rs11962292 chr6:90476788 C/T cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.51 -0.42 5.78e-16 Bipolar disorder; LUSC cis rs1371867 0.875 rs1788168 chr8:101324960 G/T cg06002616 chr8:101225028 SPAG1 -0.41 -6.95 -0.36 1.89e-11 Atrioventricular conduction; LUSC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg25036284 chr2:26402008 FAM59B -0.7 -9.85 -0.47 3.01e-20 Gut microbiome composition (summer); LUSC cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.59 -7.65 -0.39 2.24e-13 Schizophrenia; LUSC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.52 0.34 2.6e-10 Menarche (age at onset); LUSC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg19729930 chr2:74357872 NA 0.89 16.87 0.68 1.27e-46 Gestational age at birth (maternal effect); LUSC cis rs11098499 0.863 rs1010739 chr4:120463471 C/T cg24375607 chr4:120327624 NA 0.75 11.14 0.52 1.04e-24 Corneal astigmatism; LUSC cis rs1950626 0.750 rs34061904 chr14:101435974 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.77 0.39 9.83e-14 Pelvic organ prolapse (moderate/severe); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg09432166 chr1:109633189 TMEM167B 0.37 6.12 0.32 2.58e-9 Triglycerides; LUSC cis rs5769765 0.862 rs7410537 chr22:50317330 G/A cg02269571 chr22:50332266 NA -0.61 -9.0 -0.44 1.71e-17 Schizophrenia; LUSC cis rs2797160 1.000 rs1630556 chr6:126013155 A/G cg05901451 chr6:126070800 HEY2 0.57 8.66 0.43 2.04e-16 Endometrial cancer; LUSC cis rs7267979 1.000 rs2387880 chr20:25377787 T/C cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs72960926 0.744 rs6926572 chr6:75044118 A/G cg03266952 chr6:74778945 NA -0.66 -6.11 -0.32 2.73e-9 Metabolite levels (MHPG); LUSC cis rs4474465 1.000 rs7102316 chr11:78149365 C/T cg27205649 chr11:78285834 NARS2 -0.53 -6.2 -0.32 1.69e-9 Alzheimer's disease (survival time); LUSC trans rs72674100 1.000 rs61291954 chr4:97971955 C/T cg16405019 chr1:18959625 PAX7 -0.58 -6.3 -0.33 9.4e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14442939 chr10:27389572 ANKRD26 0.78 8.57 0.42 3.88e-16 Breast cancer; LUSC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg06634786 chr22:41940651 POLR3H 0.54 6.27 0.32 1.12e-9 Vitiligo; LUSC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg17264618 chr3:40429014 ENTPD3 0.36 7.51 0.38 5.36e-13 Renal cell carcinoma; LUSC cis rs2637266 1.000 rs7475638 chr10:78358586 G/T cg18941641 chr10:78392320 NA -0.39 -7.31 -0.37 1.93e-12 Pulmonary function; LUSC cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg13010199 chr12:38710504 ALG10B 0.71 12.05 0.55 5.21e-28 Heart rate; LUSC cis rs28830936 1.000 rs12440747 chr15:42036690 G/A cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.03 -0.31 4.33e-9 Diastolic blood pressure; LUSC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg13683864 chr3:40499215 RPL14 -1.13 -20.07 -0.74 2.37e-59 Renal cell carcinoma; LUSC cis rs1507153 0.604 rs236855 chr6:79341891 C/T cg05283184 chr6:79620031 NA 0.4 7.42 0.38 9.68e-13 Sjögren's syndrome; LUSC cis rs9527 0.590 rs12246739 chr10:104787019 A/C cg05855489 chr10:104503620 C10orf26 -0.5 -7.57 -0.38 3.65e-13 Arsenic metabolism; LUSC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg14895029 chr7:2775587 GNA12 -0.41 -6.28 -0.33 1.03e-9 Height; LUSC cis rs730566 0.640 rs6442112 chr3:48316034 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.4 6.24 0.32 1.35e-9 Prion diseases; LUSC cis rs10193935 1.000 rs13419669 chr2:42387254 T/C cg27598129 chr2:42591480 NA -0.59 -8.1 -0.41 1.01e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs12476592 0.571 rs196125 chr2:63859268 C/T cg10828910 chr2:63850056 LOC388955 0.48 5.7 0.3 2.69e-8 Childhood ear infection; LUSC cis rs478607 0.834 rs2666560 chr11:64480308 C/T cg19131476 chr11:64387923 NRXN2 -0.31 -5.68 -0.3 2.9e-8 Urate levels; LUSC cis rs5758511 0.680 rs58654759 chr22:42642576 T/C cg00645731 chr22:42541494 CYP2D7P1 0.57 10.0 0.48 8.88e-21 Birth weight; LUSC cis rs4319547 0.615 rs2341439 chr12:122848096 C/G cg23029597 chr12:123009494 RSRC2 -0.71 -9.35 -0.46 1.27e-18 Body mass index; LUSC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg02353165 chr6:42928485 GNMT 0.48 6.58 0.34 1.83e-10 Blood protein levels; LUSC trans rs1218582 0.774 rs4845679 chr1:154861187 G/T cg05839875 chr5:39203190 FYB -0.32 -6.14 -0.32 2.35e-9 Prostate cancer; LUSC cis rs765787 0.530 rs7165889 chr15:45531640 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.7 -0.43 1.5e-16 Uric acid levels; LUSC cis rs2242663 0.798 rs1945302 chr11:66337498 C/T cg24851651 chr11:66362959 CCS 0.37 5.9 0.31 8.71e-9 Bipolar disorder; LUSC trans rs9944275 0.860 rs34753049 chr15:97192214 T/C cg18834029 chr10:103349097 POLL;RP11-529I10.4 -0.6 -5.97 -0.31 6.23e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); LUSC cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.67 0.65 7.3e-42 Bladder cancer; LUSC cis rs11098499 0.863 rs59732491 chr4:120489588 G/C cg24375607 chr4:120327624 NA 0.77 11.56 0.53 3.04e-26 Corneal astigmatism; LUSC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg21433313 chr16:3507492 NAT15 0.82 8.86 0.44 4.9e-17 Tuberculosis; LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg08280861 chr8:58055591 NA 0.53 5.81 0.3 1.5e-8 Developmental language disorder (linguistic errors); LUSC cis rs4293296 0.525 rs761509 chr14:54820582 G/T cg02257953 chr14:54816093 NA 0.43 6.0 0.31 5.23e-9 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9467773 1.000 rs6925895 chr6:26572165 G/T cg11502198 chr6:26597334 ABT1 0.64 10.06 0.48 5.52e-21 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.79 0.43 8.13e-17 Prudent dietary pattern; LUSC cis rs9815354 0.627 rs73073268 chr3:42021403 C/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21582582 chr3:182698605 DCUN1D1 -0.46 -8.14 -0.41 8.08e-15 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg18402987 chr7:1209562 NA 0.43 5.78 0.3 1.76e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg13072238 chr3:49761600 GMPPB -0.36 -5.66 -0.3 3.24e-8 Body mass index; LUSC cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg24130564 chr14:104152367 KLC1 0.46 6.42 0.33 4.7e-10 Intelligence (multi-trait analysis); LUSC cis rs10887741 0.690 rs4934358 chr10:89439744 C/A cg13926569 chr10:89418898 PAPSS2 0.35 7.69 0.39 1.69e-13 Exercise (leisure time); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17097992 chr2:10443818 HPCAL1 0.44 5.97 0.31 6e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg12257692 chr3:49977190 RBM6 0.26 7.16 0.36 5.28e-12 Body mass index; LUSC cis rs7584330 0.518 rs113812061 chr2:238447934 T/C cg14458575 chr2:238380390 NA 0.55 6.54 0.34 2.33e-10 Prostate cancer; LUSC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg22800045 chr5:56110881 MAP3K1 0.43 5.94 0.31 7.13e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs17125944 0.505 rs2295826 chr14:53174923 C/T cg00686598 chr14:53173677 PSMC6 -1.07 -10.45 -0.5 2.57e-22 Alzheimer's disease (late onset); LUSC cis rs9467773 1.000 rs1884948 chr6:26567988 G/A cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC cis rs56804039 1.000 rs11780966 chr8:8383396 T/G cg06636001 chr8:8085503 FLJ10661 -0.54 -6.7 -0.34 8.97e-11 Cervical cancer; LUSC cis rs17789174 0.855 rs57997696 chr16:85082468 C/G cg01715842 chr16:85045600 ZDHHC7 -0.42 -5.95 -0.31 6.93e-9 Dysphagia; LUSC cis rs11711311 1.000 rs3806641 chr3:113465761 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 7.02 0.36 1.25e-11 IgG glycosylation; LUSC trans rs208515 0.525 rs10944863 chr6:66676238 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.01 13.77 0.6 1.75e-34 Exhaled nitric oxide levels; LUSC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg15664640 chr17:80829946 TBCD 0.69 12.05 0.55 5.11e-28 Breast cancer; LUSC cis rs9303542 0.559 rs8079617 chr17:46610028 T/G cg09704116 chr17:46666958 LOC404266 -0.37 -6.52 -0.34 2.56e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg20573242 chr4:122745356 CCNA2 0.64 9.22 0.45 3.55e-18 Type 2 diabetes; LUSC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.85 0.35 3.67e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2481665 0.772 rs6661862 chr1:62534854 A/C cg18591186 chr1:62594603 INADL 0.45 7.07 0.36 9.21e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6547741 0.935 rs56001553 chr2:27859926 C/T cg27432699 chr2:27873401 GPN1 -0.8 -14.43 -0.62 5.28e-37 Oral cavity cancer; LUSC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg13393036 chr8:95962371 TP53INP1 -0.46 -10.16 -0.49 2.68e-21 Type 2 diabetes; LUSC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.43 -6.7 -0.34 9.04e-11 Systemic lupus erythematosus; LUSC cis rs11229555 0.874 rs11605297 chr11:58296806 G/A cg15696309 chr11:58395628 NA -0.69 -8.8 -0.43 7.59e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2580764 0.565 rs6545466 chr2:55228392 C/T cg09592903 chr2:55203963 RTN4 -0.48 -9.98 -0.48 1.04e-20 Mean platelet volume; LUSC cis rs11785400 0.793 rs2978973 chr8:143747271 C/G cg10596483 chr8:143751796 JRK 0.55 7.85 0.39 5.61e-14 Schizophrenia; LUSC cis rs4906332 1.000 rs35366629 chr14:103903054 A/G cg04998671 chr14:104000505 TRMT61A -0.44 -6.77 -0.35 5.87e-11 Coronary artery disease; LUSC trans rs11098499 0.566 rs7664440 chr4:120578540 A/G cg25214090 chr10:38739885 LOC399744 0.5 7.28 0.37 2.36e-12 Corneal astigmatism; LUSC cis rs1018836 0.570 rs6471084 chr8:91463666 T/C cg16814680 chr8:91681699 NA -0.52 -7.5 -0.38 5.73e-13 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.91 -0.48 1.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg26408565 chr15:76604113 ETFA -0.43 -6.72 -0.34 8.07e-11 Blood metabolite levels; LUSC cis rs2124969 0.527 rs72982044 chr2:161049395 G/A cg03641300 chr2:160917029 PLA2R1 -0.46 -5.69 -0.3 2.72e-8 Waist circumference adjusted for body mass index; LUSC cis rs1476679 1.000 rs34919929 chr7:100012334 G/A cg19116668 chr7:99932089 PMS2L1 0.42 7.48 0.38 6.71e-13 Alzheimer's disease (late onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03923274 chr14:23388278 RBM23 -0.45 -5.95 -0.31 6.69e-9 Hepatitis; LUSC cis rs9486719 0.741 rs976356 chr6:96849437 T/A cg06623918 chr6:96969491 KIAA0776 0.74 8.79 0.43 8.3e-17 Migraine;Coronary artery disease; LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg22920501 chr2:26401640 FAM59B -0.8 -11.89 -0.55 1.96e-27 Gut microbiome composition (summer); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14764512 chr3:49058575 MIR191;DALRD3;NDUFAF3;MIR425 0.38 6.15 0.32 2.21e-9 Asthma; LUSC cis rs1018697 0.966 rs1475643 chr10:104546467 C/T cg04362960 chr10:104952993 NT5C2 0.46 6.29 0.33 9.99e-10 Colorectal adenoma (advanced); LUSC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.1 0.48 4.18e-21 Bipolar disorder; LUSC trans rs35851103 0.507 rs6601649 chr8:11857317 A/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.18 -0.32 1.84e-9 Neuroticism; LUSC cis rs3755132 0.929 rs57349592 chr2:15738959 C/T cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.68e-12 Wilms tumor; LUSC cis rs926938 0.563 rs360630 chr1:115415132 C/T cg12756093 chr1:115239321 AMPD1 0.45 6.53 0.34 2.45e-10 Autism; LUSC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg23711669 chr6:146136114 FBXO30 0.78 12.94 0.58 2.45e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs1322639 1.000 rs9689079 chr6:169587148 A/G cg03254818 chr6:169586852 NA -0.45 -6.31 -0.33 8.81e-10 Pulse pressure; LUSC trans rs72674100 1.000 rs72882343 chr4:97993924 G/A cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs72792276 1.000 rs3805608 chr5:127480998 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.88 8.07 0.4 1.25e-14 Red cell distribution width; LUSC cis rs1595825 0.786 rs16826740 chr2:198893927 A/G cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs10911363 0.549 rs2794619 chr1:183459670 G/A cg09173681 chr1:183549694 NCF2 0.64 11.43 0.53 9.04e-26 Systemic lupus erythematosus; LUSC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg04352962 chr1:209979756 IRF6 0.52 5.79 0.3 1.65e-8 Cleft lip with or without cleft palate; LUSC trans rs3733585 0.773 rs13107466 chr4:10019390 G/A cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6542838 0.641 rs6542841 chr2:99489039 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.65 -0.3 3.4e-8 Fear of minor pain; LUSC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 2e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg07507251 chr3:52567010 NT5DC2 0.32 6.13 0.32 2.44e-9 Bipolar disorder; LUSC cis rs7267979 0.565 rs4815437 chr20:25584788 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -12.37 -0.56 3.44e-29 Liver enzyme levels (alkaline phosphatase); LUSC trans rs7568069 0.741 rs6726122 chr2:71583924 A/T cg06465196 chr4:154387603 KIAA0922 0.43 6.12 0.32 2.67e-9 Height; LUSC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg21033440 chr11:65409861 SIPA1 -0.54 -7.59 -0.38 3.22e-13 Blood pressure (age interaction); LUSC cis rs9300255 0.507 rs1727302 chr12:123632930 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.78 -0.35 5.37e-11 Neutrophil percentage of white cells; LUSC cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg06784218 chr1:46089804 CCDC17 0.48 9.55 0.46 2.81e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.9 0.35 2.64e-11 Tonsillectomy; LUSC cis rs4919694 1.000 rs4919694 chr10:104698978 T/C cg23093090 chr10:104574429 C10orf26 -0.45 -5.69 -0.3 2.79e-8 Arsenic metabolism; LUSC cis rs3806843 0.576 rs246005 chr5:140339884 A/C cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg04851639 chr8:1020857 NA -0.34 -6.96 -0.36 1.86e-11 Schizophrenia; LUSC trans rs11700980 1.000 rs16983164 chr21:30121450 C/A cg05609335 chr17:75789393 NA 0.41 6.32 0.33 8.58e-10 QRS complex (12-leadsum); LUSC cis rs4908769 0.627 rs2252865 chr1:8422676 T/C cg00546117 chr1:8445545 RERE 0.29 5.68 0.3 2.89e-8 Allergy; LUSC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.37 -6.48 -0.33 3.32e-10 High light scatter reticulocyte count; LUSC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.36 0.53 1.6e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7707921 1.000 rs6884232 chr5:81550043 G/A cg15871215 chr5:81402204 ATG10 0.44 6.46 0.33 3.68e-10 Breast cancer; LUSC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg22875332 chr1:76189707 ACADM 0.85 17.82 0.7 2.17e-50 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg08736216 chr1:53307985 ZYG11A 0.29 6.03 0.31 4.36e-9 Monocyte count; LUSC cis rs1355223 0.573 rs2084970 chr11:34723729 G/A cg11058730 chr11:34937778 PDHX;APIP -0.44 -6.13 -0.32 2.44e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg00149659 chr3:10157352 C3orf10 0.88 12.24 0.56 9.98e-29 Alzheimer's disease; LUSC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg25036284 chr2:26402008 FAM59B 0.77 10.94 0.51 5.08e-24 Gut microbiome composition (summer); LUSC cis rs2197308 0.765 rs10880643 chr12:37926452 C/T cg26384229 chr12:38710491 ALG10B -0.82 -13.55 -0.6 1.28e-33 Morning vs. evening chronotype; LUSC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg21361702 chr7:150065534 REPIN1 0.54 6.95 0.36 1.89e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11644478 chr21:40555479 PSMG1 0.81 14.63 0.62 8.81e-38 Cognitive function; LUSC cis rs12493885 0.585 rs61790899 chr3:153642124 C/T cg17054900 chr3:154042577 DHX36 -0.59 -6.14 -0.32 2.34e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs367615 0.552 rs2963023 chr5:108730070 C/T cg17395555 chr5:108820864 NA -0.46 -7.99 -0.4 2.2e-14 Colorectal cancer (SNP x SNP interaction); LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC cis rs6545883 0.929 rs2256615 chr2:61679894 C/G cg15711740 chr2:61764176 XPO1 -0.46 -6.91 -0.35 2.39e-11 Tuberculosis; LUSC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18099408 chr3:52552593 STAB1 -0.43 -7.59 -0.38 3.17e-13 Bipolar disorder; LUSC cis rs2274273 0.870 rs6573009 chr14:55682324 A/C cg04306507 chr14:55594613 LGALS3 0.58 13.84 0.6 9.53e-35 Protein biomarker; LUSC cis rs2070488 0.662 rs7652475 chr3:38481341 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 10.44 0.5 2.85e-22 Electrocardiographic conduction measures; LUSC cis rs2303282 0.716 rs6499837 chr16:56453981 C/T cg00500540 chr16:56394104 NA 0.43 7.36 0.37 1.49e-12 Breast cancer; LUSC cis rs11679564 0.714 rs4670638 chr2:37164911 C/G cg14987922 chr2:37194071 STRN 0.63 9.64 0.47 1.43e-19 Immature fraction of reticulocytes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06090383 chr4:174292579 SAP30 0.49 6.8 0.35 4.77e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs9951602 0.512 rs9952372 chr18:76656295 A/G cg02800362 chr5:177631904 HNRNPAB 0.87 12.96 0.58 2.18e-31 Obesity-related traits; LUSC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg19812747 chr11:111475976 SIK2 0.5 7.32 0.37 1.89e-12 Primary sclerosing cholangitis; LUSC cis rs561341 0.882 rs504887 chr17:30322881 T/A cg00745463 chr17:30367425 LRRC37B -0.81 -9.48 -0.46 4.82e-19 Hip circumference adjusted for BMI; LUSC cis rs2067615 0.507 rs10746063 chr12:107086240 G/T cg15890332 chr12:107067104 RFX4 0.35 6.13 0.32 2.51e-9 Heart rate; LUSC cis rs2273669 0.588 rs111353760 chr6:109306493 T/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.21 -0.32 1.62e-9 Prostate cancer; LUSC cis rs3806843 0.931 rs13168670 chr5:140146899 T/C cg26395211 chr5:140044315 WDR55 -0.38 -5.77 -0.3 1.85e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg25319279 chr11:5960081 NA -0.39 -6.25 -0.32 1.22e-9 DNA methylation (variation); LUSC cis rs7100689 0.577 rs10788545 chr10:82034675 A/G cg01528321 chr10:82214614 TSPAN14 0.95 14.47 0.62 3.61e-37 Post bronchodilator FEV1; LUSC cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg08999081 chr20:33150536 PIGU 0.5 10.05 0.48 6.07e-21 Glomerular filtration rate (creatinine); LUSC cis rs10464366 1.000 rs10951593 chr7:39121390 C/T cg15212455 chr7:39170539 POU6F2 0.51 7.86 0.4 5.17e-14 IgG glycosylation; LUSC cis rs2270431 1 rs2270431 chr14:75270635 T/C cg08847533 chr14:75593920 NEK9 0.45 6.26 0.32 1.16e-9 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24928681 chr11:74700231 NEU3 0.48 7.26 0.37 2.74e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg06544989 chr22:39130855 UNC84B 0.33 5.76 0.3 1.86e-8 Menopause (age at onset); LUSC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg16060761 chr17:80687452 NA 0.4 6.17 0.32 2.03e-9 Breast cancer; LUSC cis rs6542838 0.580 rs1607256 chr2:99543444 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.88 -0.35 3.01e-11 Fear of minor pain; LUSC cis rs477692 1.000 rs508303 chr10:131424996 A/T cg26102564 chr10:131424627 MGMT -0.39 -6.2 -0.32 1.69e-9 Response to temozolomide; LUSC cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg13256891 chr4:100009986 ADH5 0.48 7.11 0.36 7.05e-12 Alcohol dependence; LUSC cis rs897984 0.646 rs9938088 chr16:30830004 G/A cg00531865 chr16:30841666 NA -0.33 -5.92 -0.31 7.93e-9 Dementia with Lewy bodies; LUSC cis rs72960926 0.744 rs11755740 chr6:74934131 C/T cg03266952 chr6:74778945 NA -0.84 -7.01 -0.36 1.33e-11 Metabolite levels (MHPG); LUSC cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg12826209 chr6:26865740 GUSBL1 -0.72 -8.99 -0.44 1.84e-17 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs7343481 chr20:25300113 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.57 -0.75 2.54e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6547741 1.000 rs10165098 chr2:27796526 C/T cg27432699 chr2:27873401 GPN1 0.8 14.99 0.63 3.32e-39 Oral cavity cancer; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg23978390 chr7:1156363 C7orf50 0.48 6.83 0.35 3.98e-11 Longevity;Endometriosis; LUSC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.75 0.39 1.1e-13 Electroencephalogram traits; LUSC cis rs9796 0.621 rs1659227 chr15:41472398 G/A cg18705301 chr15:41695430 NDUFAF1 0.49 8.54 0.42 4.68e-16 Menopause (age at onset); LUSC cis rs3008870 1.000 rs2755244 chr1:67484470 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.91 -15.2 -0.64 5.23e-40 Lymphocyte percentage of white cells; LUSC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs500891 0.525 rs7774996 chr6:84073387 A/G cg08257003 chr6:84140564 ME1 0.35 8.49 0.42 6.69e-16 Platelet-derived growth factor BB levels; LUSC cis rs1775715 0.707 rs2808081 chr10:32162342 C/T cg26784012 chr10:32216390 ARHGAP12 -0.42 -7.11 -0.36 7.31e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg06263672 chr7:65235340 NA 0.44 6.26 0.32 1.16e-9 Calcium levels; LUSC cis rs2078087 0.831 rs10494561 chr1:183247090 C/T cg13843938 chr1:183241246 NMNAT2 0.46 6.08 0.32 3.3e-9 Obesity-related traits; LUSC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -7.99 -0.4 2.28e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg00101154 chr16:420108 MRPL28 -0.43 -6.45 -0.33 3.84e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs34526934 0.566 rs62624470 chr2:177040907 C/T cg26754761 chr2:177040938 NA -0.4 -7.82 -0.39 7.19e-14 Obstructive sleep apnea trait (apnea hypopnea index); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg18177682 chr1:160175593 PEA15 0.4 6.1 0.32 3.01e-9 Schizophrenia; LUSC cis rs4689388 0.926 rs4688987 chr4:6287329 C/T cg25554036 chr4:6271136 WFS1 0.62 13.02 0.58 1.27e-31 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11098499 1.000 rs35643470 chr4:120184948 T/C cg09307838 chr4:120376055 NA 0.68 9.61 0.47 1.77e-19 Corneal astigmatism; LUSC cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.2 0.49 1.94e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21877580 chr6:97731105 MIR548H3;C6orf167 -0.46 -6.88 -0.35 2.88e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg26272105 chr1:47644977 NA -0.46 -7.14 -0.36 5.77e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02809263 chr1:70671218 LRRC40;SFRS11 0.42 6.23 0.32 1.39e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1864400 0.690 rs7098237 chr10:43740513 T/A cg07801480 chr10:43725741 RASGEF1A -0.39 -5.88 -0.31 1.01e-8 Hirschsprung disease; LUSC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7903847 0.642 rs9888117 chr10:99159963 C/G cg08345082 chr10:99160200 RRP12 -0.33 -6.87 -0.35 3.15e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg04398451 chr17:18023971 MYO15A -0.46 -7.38 -0.37 1.31e-12 Total body bone mineral density; LUSC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg06074448 chr4:187884817 NA -0.41 -6.89 -0.35 2.85e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg16322792 chr1:120165303 ZNF697 0.74 15.5 0.65 3.38e-41 Systemic lupus erythematosus; LUSC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg11645453 chr3:52864694 ITIH4 0.34 8.09 0.4 1.13e-14 Bipolar disorder; LUSC cis rs6964587 1.000 rs36120033 chr7:91679298 G/A cg22709100 chr7:91322751 NA 0.39 5.79 0.3 1.67e-8 Breast cancer; LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg00684032 chr4:1343700 KIAA1530 0.35 6.22 0.32 1.52e-9 Obesity-related traits; LUSC cis rs72781680 0.898 rs72788212 chr2:24087385 G/A cg08917208 chr2:24149416 ATAD2B 0.88 10.02 0.48 7.83e-21 Lymphocyte counts; LUSC trans rs2204008 0.713 rs2320522 chr12:38251438 C/T cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg10729496 chr3:10149963 C3orf24 0.55 7.48 0.38 6.76e-13 Alzheimer's disease; LUSC cis rs433852 0.898 rs376524 chr19:49116438 A/G cg06530960 chr19:49140787 SEC1;DBP -0.72 -9.26 -0.45 2.53e-18 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg14829155 chr15:31115871 NA 0.45 6.27 0.32 1.09e-9 Huntington's disease progression; LUSC cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg22496339 chr2:162101262 NA 0.52 7.64 0.39 2.35e-13 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg00990874 chr7:1149470 C7orf50 -0.55 -7.17 -0.37 4.94e-12 Bronchopulmonary dysplasia; LUSC trans rs57046232 0.552 rs6085497 chr20:6315937 A/G cg17788362 chr6:86352627 SYNCRIP 0.46 6.42 0.33 4.68e-10 Colorectal cancer; LUSC trans rs629535 0.725 rs639127 chr8:70073251 A/G cg21567404 chr3:27674614 NA 0.98 15.7 0.65 5.44e-42 Dupuytren's disease; LUSC cis rs10193935 0.892 rs12612372 chr2:42414035 A/G cg27598129 chr2:42591480 NA -0.61 -8.05 -0.4 1.48e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg09035930 chr12:129282057 SLC15A4 0.73 16.0 0.66 3.52e-43 Systemic lupus erythematosus; LUSC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 14.7 0.63 4.49e-38 Platelet count; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg08859206 chr1:53392774 SCP2 -0.54 -9.57 -0.46 2.45e-19 Monocyte count; LUSC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg15448220 chr1:150897856 SETDB1 0.39 5.66 0.3 3.19e-8 Melanoma; LUSC cis rs12477438 0.715 rs7586608 chr2:99558017 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -7.92 -0.4 3.65e-14 Chronic sinus infection; LUSC cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg24296786 chr1:45957014 TESK2 -0.51 -7.54 -0.38 4.33e-13 High light scatter reticulocyte count; LUSC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg07424592 chr7:64974309 NA 0.69 6.19 0.32 1.81e-9 Diabetic kidney disease; LUSC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg09165964 chr15:75287851 SCAMP5 0.55 7.98 0.4 2.42e-14 Breast cancer; LUSC trans rs12692738 0.526 rs355846 chr2:165624586 C/T cg26993132 chr16:89239499 CDH15 -0.3 -5.99 -0.31 5.43e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7267979 1.000 rs6050626 chr20:25428261 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.87 20.01 0.74 4.1e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs637571 0.780 rs677029 chr11:65683531 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.46 8.38 0.42 1.46e-15 Eosinophil percentage of white cells; LUSC cis rs7119 0.623 rs12905318 chr15:77845873 T/C cg27398640 chr15:77910606 LINGO1 -0.32 -6.92 -0.35 2.32e-11 Type 2 diabetes; LUSC cis rs34779708 0.966 rs12762493 chr10:35471873 G/A cg03585969 chr10:35415529 CREM 0.62 9.22 0.45 3.45e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9807989 0.801 rs6752482 chr2:102967858 T/C cg09003973 chr2:102972529 NA 0.44 6.05 0.31 3.93e-9 Asthma; LUSC cis rs12541635 0.966 rs6987512 chr8:106998770 C/T cg10147462 chr8:107024639 NA 0.55 9.93 0.48 1.52e-20 Age of smoking initiation; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23647884 chr3:120315025 NDUFB4 -0.42 -6.24 -0.32 1.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T ch.13.865492R chr13:60543691 DIAPH3 -0.45 -6.96 -0.36 1.82e-11 Leprosy; LUSC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg03806693 chr22:41940476 POLR3H 0.99 14.03 0.61 1.78e-35 Vitiligo; LUSC cis rs1451375 0.698 rs11489736 chr7:50645372 G/A cg18232548 chr7:50535776 DDC 0.5 7.58 0.38 3.49e-13 Malaria; LUSC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg10792982 chr14:105748885 BRF1 0.45 7.94 0.4 3.01e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs10751667 1.000 rs7395691 chr11:985006 T/C cg01483505 chr11:975446 AP2A2 0.43 6.04 0.31 4.05e-9 Alzheimer's disease (late onset); LUSC cis rs4919087 1.000 rs10786327 chr10:99071408 C/T cg25902810 chr10:99078978 FRAT1 0.49 7.22 0.37 3.48e-12 Monocyte count; LUSC trans rs12210905 0.688 rs10456051 chr6:27463436 T/C cg14616345 chr9:133901267 LAMC3 -0.7 -5.99 -0.31 5.54e-9 Hip circumference adjusted for BMI; LUSC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -7.31 -0.37 2e-12 Coronary artery disease; LUSC cis rs60695258 0.550 rs4693798 chr4:87914288 G/C cg10685359 chr4:87814065 C4orf36 0.33 5.91 0.31 8.26e-9 Hematocrit; LUSC cis rs9640161 0.617 rs73170169 chr7:150008036 G/A cg10018233 chr7:150070692 REPIN1 0.34 5.7 0.3 2.6e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg09044154 chr16:88155775 NA -0.56 -7.62 -0.38 2.6e-13 Menopause (age at onset); LUSC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg18512352 chr11:47633146 NA -0.46 -9.22 -0.45 3.43e-18 Subjective well-being; LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.61 0.34 1.5e-10 Menopause (age at onset); LUSC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.85 0.66 1.36e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg09267113 chr7:98030324 BAIAP2L1 0.38 5.83 0.3 1.29e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs72720396 0.694 rs6689362 chr1:91203251 T/A cg13456504 chr1:91191583 NA -0.39 -5.74 -0.3 2.09e-8 Morning vs. evening chronotype;Chronotype; LUSC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.41 6.54 0.34 2.3e-10 Schizophrenia; LUSC cis rs4595586 0.545 rs7308161 chr12:39363459 A/G cg13010199 chr12:38710504 ALG10B 0.41 6.02 0.31 4.6e-9 Morning vs. evening chronotype; LUSC cis rs2692947 0.727 rs749457 chr2:96795944 A/G cg22654517 chr2:96458247 NA 0.37 7.36 0.37 1.44e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs13202913 0.518 rs13205543 chr6:151813779 C/T cg03627880 chr6:151815985 C6orf97 -0.56 -5.9 -0.31 8.82e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg11764359 chr7:65958608 NA 0.51 6.67 0.34 1.09e-10 Aortic root size; LUSC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg06238570 chr21:40685208 BRWD1 -0.57 -9.0 -0.44 1.78e-17 Menarche (age at onset); LUSC cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg19592336 chr6:28129416 ZNF389 0.49 6.5 0.34 2.96e-10 Depression; LUSC trans rs9650657 0.740 rs34653170 chr8:10676542 G/T cg15556689 chr8:8085844 FLJ10661 -0.4 -6.01 -0.31 4.95e-9 Neuroticism; LUSC cis rs2295359 1.000 rs963427 chr1:67609347 A/G cg03340356 chr1:67600835 NA 0.43 6.93 0.35 2.22e-11 Psoriasis; LUSC cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg24812749 chr6:127587940 RNF146 0.92 13.89 0.6 6.41e-35 Breast cancer; LUSC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.546 rs1863602 chr4:98909304 T/C cg17366294 chr4:99064904 C4orf37 0.52 8.46 0.42 8.33e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs738322 0.967 rs4380 chr22:38569529 T/C cg25457927 chr22:38595422 NA -0.41 -8.74 -0.43 1.14e-16 Cutaneous nevi; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10572969 chr11:13690188 FAR1 -0.5 -6.12 -0.32 2.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.26 0.37 2.75e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1692580 0.846 rs377599 chr1:2164699 C/T cg24578937 chr1:2090814 PRKCZ 0.38 7.83 0.39 6.45e-14 Coronary artery disease; LUSC cis rs950169 0.922 rs12910334 chr15:84958318 G/A cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.52e-15 Schizophrenia; LUSC cis rs73198271 0.740 rs10100066 chr8:8650393 T/G cg01851573 chr8:8652454 MFHAS1 0.52 8.36 0.42 1.69e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7072216 0.763 rs7923729 chr10:100169465 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.86 -0.44 4.94e-17 Metabolite levels; LUSC cis rs3768617 0.811 rs12120747 chr1:183042531 G/A ch.1.3577855R chr1:183094577 LAMC1 0.6 8.64 0.43 2.29e-16 Fuchs's corneal dystrophy; LUSC cis rs9296092 0.517 rs9461876 chr6:33516657 C/T cg13560919 chr6:33536144 NA -0.82 -15.45 -0.65 5.48e-41 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg07395648 chr5:131743802 NA 0.39 6.12 0.32 2.55e-9 Asthma (sex interaction); LUSC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg08847533 chr14:75593920 NEK9 0.84 15.62 0.65 1.14e-41 Height; LUSC cis rs239198 0.602 rs9377236 chr6:101289960 A/G cg09795085 chr6:101329169 ASCC3 0.45 6.35 0.33 7.02e-10 Menarche (age at onset); LUSC cis rs72772090 0.634 rs10515246 chr5:96099265 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.73 -8.27 -0.41 3.12e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg07677032 chr17:61819896 STRADA 0.44 7.33 0.37 1.78e-12 Prudent dietary pattern; LUSC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg15704280 chr7:45808275 SEPT13 1.02 17.45 0.69 6.44e-49 Coronary artery disease; LUSC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg17143192 chr8:8559678 CLDN23 0.39 5.93 0.31 7.36e-9 Mood instability; LUSC cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg21427119 chr20:30132790 HM13 -0.36 -5.67 -0.3 3.14e-8 Mean corpuscular hemoglobin; LUSC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg09365446 chr1:150670422 GOLPH3L 0.5 7.43 0.38 9.44e-13 Melanoma; LUSC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg05090351 chr10:126851162 NA -0.42 -6.78 -0.35 5.5e-11 Menarche (age at onset); LUSC cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.3 0.37 2.16e-12 Motion sickness; LUSC cis rs3845702 0.736 rs3845701 chr2:180826781 A/G cg01881094 chr2:180872142 CWC22 -1.04 -12.47 -0.56 1.5e-29 Schizophrenia; LUSC cis rs9646944 0.501 rs9807934 chr2:103040182 T/G cg20060108 chr2:102954350 IL1RL1 0.48 6.56 0.34 2.1e-10 Blood protein levels; LUSC cis rs9527 0.590 rs11191544 chr10:104827198 C/G cg05855489 chr10:104503620 C10orf26 0.53 7.99 0.4 2.26e-14 Arsenic metabolism; LUSC cis rs79387448 0.745 rs17027442 chr2:103164948 A/G cg09003973 chr2:102972529 NA -0.87 -8.41 -0.42 1.17e-15 Gut microbiota (bacterial taxa); LUSC cis rs3862435 0.518 rs2589960 chr15:90916387 A/G cg22089800 chr15:90895588 ZNF774 0.58 6.2 0.32 1.62e-9 Response to exercise (triglyceride level interaction); LUSC cis rs9549367 0.865 rs9549366 chr13:113907644 G/A cg18105134 chr13:113819100 PROZ -0.65 -9.59 -0.46 2.1e-19 Platelet distribution width; LUSC cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg18721089 chr20:30220636 NA -0.4 -6.72 -0.35 7.91e-11 Mean corpuscular hemoglobin; LUSC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg15445000 chr17:37608096 MED1 -0.39 -6.73 -0.35 7.47e-11 Glomerular filtration rate (creatinine); LUSC trans rs8002861 0.664 rs4942246 chr13:44404853 A/G cg12856521 chr11:46389249 DGKZ 0.43 6.33 0.33 7.82e-10 Leprosy; LUSC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.49 0.53 5.79e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg23102388 chr7:1867652 MAD1L1 -0.32 -6.03 -0.31 4.29e-9 Bipolar disorder and schizophrenia; LUSC cis rs67981189 0.572 rs7156009 chr14:71515431 G/A cg15816911 chr14:71606274 NA 0.33 5.92 0.31 8e-9 Schizophrenia; LUSC cis rs12464483 0.524 rs1901906 chr2:30884576 A/G cg17749961 chr2:30669863 LCLAT1 -0.63 -8.0 -0.4 2.1e-14 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.63 -13.69 -0.6 3.6e-34 Hemoglobin concentration; LUSC cis rs56283067 0.887 rs9463043 chr6:44771114 T/C cg20913747 chr6:44695427 NA -0.47 -7.22 -0.37 3.63e-12 Total body bone mineral density; LUSC cis rs9291683 0.588 rs4280729 chr4:10013861 C/T cg11266682 chr4:10021025 SLC2A9 0.56 10.33 0.49 6.79e-22 Bone mineral density; LUSC cis rs1965732 0.958 rs6755529 chr2:3711972 C/T cg19052272 chr2:3704530 ALLC 0.35 6.68 0.34 9.83e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs73206853 0.764 rs7980838 chr12:110672978 T/A cg12870014 chr12:110450643 ANKRD13A 0.69 7.99 0.4 2.25e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg26384229 chr12:38710491 ALG10B 0.92 17.33 0.69 1.91e-48 Heart rate; LUSC cis rs6940638 0.688 rs7764984 chr6:27034181 A/G cg09904177 chr6:26538194 HMGN4 -0.43 -6.21 -0.32 1.54e-9 Intelligence (multi-trait analysis); LUSC trans rs6076960 0.846 rs6053962 chr20:6176915 A/G cg17788362 chr6:86352627 SYNCRIP 0.4 6.06 0.31 3.59e-9 Smooth-surface caries; LUSC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg17330251 chr7:94953956 PON1 -0.38 -5.97 -0.31 6.02e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2732480 0.557 rs2409004 chr12:48721451 T/C cg04545296 chr12:48745243 ZNF641 0.34 6.26 0.32 1.2e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg18876405 chr7:65276391 NA 0.59 9.69 0.47 1.01e-19 Aortic root size; LUSC cis rs11583043 0.831 rs6667818 chr1:101412313 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.3 0.33 9.14e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs897080 0.515 rs1067398 chr2:44678882 A/G cg00619915 chr2:44497795 NA -0.45 -6.45 -0.33 3.83e-10 Height; LUSC cis rs2742417 1.000 rs1969624 chr3:45734818 C/T cg04837898 chr3:45731254 SACM1L 0.36 5.86 0.31 1.13e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs644799 0.526 rs693792 chr11:95622200 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.61 8.93 0.44 2.99e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4242434 0.927 rs13271626 chr8:22467760 C/G cg03733263 chr8:22462867 KIAA1967 0.99 17.76 0.7 3.67e-50 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2742417 1.000 rs2742373 chr3:45784046 C/G cg18779283 chr3:45636154 LIMD1 -0.33 -5.65 -0.3 3.49e-8 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs1945213 0.694 rs7106894 chr11:55877315 T/C cg03929089 chr4:120376271 NA 0.69 7.63 0.39 2.4e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg27170947 chr2:26402098 FAM59B 0.72 10.94 0.51 5.29e-24 Gut microbiome composition (summer); LUSC cis rs4561483 0.801 rs33640 chr16:11986874 C/T cg08843971 chr16:11963173 GSPT1 -0.46 -6.95 -0.36 1.95e-11 Testicular germ cell tumor; LUSC cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 7.08 0.36 8.46e-12 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg20503657 chr10:835505 NA 0.79 9.87 0.48 2.49e-20 Eosinophil percentage of granulocytes; LUSC cis rs11190604 1.000 rs11190601 chr10:102296730 A/G cg23241863 chr10:102295624 HIF1AN 0.48 5.89 0.31 9.39e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs72960926 0.744 rs9359077 chr6:74982166 T/C cg03266952 chr6:74778945 NA -0.56 -5.72 -0.3 2.37e-8 Metabolite levels (MHPG); LUSC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg15691649 chr6:25882328 NA -0.41 -6.0 -0.31 5.04e-9 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.620 rs2504566 chr6:26660488 G/C cg11502198 chr6:26597334 ABT1 0.73 12.25 0.56 9.63e-29 Intelligence (multi-trait analysis); LUSC cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg15839431 chr19:19639596 YJEFN3 -0.59 -6.51 -0.34 2.79e-10 Bipolar disorder; LUSC trans rs61931739 0.517 rs1843735 chr12:34047389 C/G cg13010199 chr12:38710504 ALG10B 0.52 7.91 0.4 3.72e-14 Morning vs. evening chronotype; LUSC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg15145296 chr3:125709740 NA -0.57 -6.36 -0.33 6.67e-10 Blood pressure (smoking interaction); LUSC cis rs3540 0.512 rs8033818 chr15:91075535 C/T cg22089800 chr15:90895588 ZNF774 -0.62 -9.4 -0.46 9.14e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.53 -7.42 -0.38 9.86e-13 Mean platelet volume; LUSC trans rs12188164 1.000 rs56104584 chr5:437542 T/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 6.04 0.31 4.19e-9 Cystic fibrosis severity; LUSC cis rs9303401 0.659 rs12935851 chr17:56600244 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.33 0.59 8.6e-33 Cognitive test performance; LUSC cis rs10489202 0.632 rs202273 chr1:167919963 A/G cg24449463 chr1:168025552 DCAF6 -0.69 -11.65 -0.54 1.44e-26 Schizophrenia; LUSC cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6456156 0.875 rs55802221 chr6:167517320 G/A cg07741184 chr6:167504864 NA -0.36 -6.4 -0.33 5.39e-10 Primary biliary cholangitis; LUSC cis rs17540621 1.000 rs10196993 chr2:47240485 G/C cg23978866 chr2:47230407 TTC7A -0.75 -5.86 -0.31 1.14e-8 Response to statin therapy; LUSC cis rs644799 0.710 rs522536 chr11:95528714 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.86 0.6 8.34e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg19628046 chr18:33552617 C18orf21 0.52 6.34 0.33 7.31e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg05283184 chr6:79620031 NA -0.46 -8.63 -0.43 2.52e-16 Intelligence (multi-trait analysis); LUSC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg26897989 chr16:1907736 C16orf73 -0.47 -7.11 -0.36 7.19e-12 Ankle injury; LUSC cis rs17685 0.753 rs11764129 chr7:75761890 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9303401 0.659 rs34913878 chr17:56897094 A/G cg25039879 chr17:56429692 SUPT4H1 0.67 9.01 0.44 1.65e-17 Cognitive test performance; LUSC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg23711669 chr6:146136114 FBXO30 0.7 10.7 0.51 3.56e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs1322512 1.000 rs2800632 chr6:153008632 C/A cg27316956 chr6:152958899 SYNE1 0.35 6.17 0.32 1.97e-9 Tonometry; LUSC cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg08754478 chr10:133766260 PPP2R2D 0.56 7.29 0.37 2.28e-12 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg18132916 chr6:79620363 NA -0.38 -5.75 -0.3 2.03e-8 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.506 rs17689674 chr8:9981854 C/A cg08975724 chr8:8085496 FLJ10661 0.45 6.47 0.33 3.44e-10 Neuroticism; LUSC trans rs2832191 0.716 rs1984012 chr21:30392472 T/C cg14791747 chr16:20752902 THUMPD1 -0.4 -6.2 -0.32 1.62e-9 Dental caries; LUSC cis rs963731 0.579 rs7594644 chr2:39206456 A/C cg04010122 chr2:39346883 SOS1 -0.78 -5.7 -0.3 2.71e-8 Corticobasal degeneration; LUSC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg20476274 chr7:133979776 SLC35B4 0.88 16.77 0.68 3.06e-46 Mean platelet volume; LUSC cis rs7267979 1.000 rs2258719 chr20:25275843 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.84 17.95 0.7 6.66e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs3862435 0.764 rs16974212 chr15:91015901 C/T cg22089800 chr15:90895588 ZNF774 0.54 5.79 0.3 1.64e-8 Response to exercise (triglyceride level interaction); LUSC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.65 0.3 3.47e-8 Intelligence (multi-trait analysis); LUSC cis rs9329289 0.550 rs11251294 chr10:2562328 C/T cg05625103 chr10:2543513 NA -0.43 -6.09 -0.32 3.13e-9 Age-related hearing impairment; LUSC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.63 9.76 0.47 5.9e-20 Cognitive test performance; LUSC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg03351412 chr1:154909251 PMVK 0.42 6.42 0.33 4.69e-10 Prostate cancer; LUSC trans rs4689592 0.513 rs4689586 chr4:7067413 A/G cg07817883 chr1:32538562 TMEM39B -0.61 -7.45 -0.38 7.97e-13 Monocyte percentage of white cells; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16575025 chr1:112281790 C1orf183 -0.52 -6.2 -0.32 1.71e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg06873352 chr17:61820015 STRADA 0.73 13.1 0.58 6.42e-32 Prudent dietary pattern; LUSC cis rs231513 0.911 rs124719 chr17:41960343 T/C cg26893861 chr17:41843967 DUSP3 -0.49 -5.85 -0.3 1.17e-8 Cognitive function; LUSC cis rs6840360 1.000 rs28637056 chr4:152652501 A/G cg22705602 chr4:152727874 NA -0.28 -6.06 -0.31 3.76e-9 Intelligence (multi-trait analysis); LUSC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg20135002 chr11:47629003 NA -0.52 -7.99 -0.4 2.2e-14 Subjective well-being; LUSC cis rs9399401 0.925 rs1360194 chr6:142752595 A/G cg03128060 chr6:142623767 GPR126 -0.31 -5.86 -0.31 1.12e-8 Chronic obstructive pulmonary disease; LUSC cis rs941764 0.965 rs941765 chr14:91841358 G/C cg10511902 chr14:91842949 CCDC88C 0.43 7.27 0.37 2.62e-12 Breast cancer; LUSC cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg13319975 chr6:146136371 FBXO30 -0.47 -6.94 -0.36 2.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs78572108 0.858 rs4468862 chr2:42265846 C/T cg00607755 chr2:42274082 PKDCC 0.36 6.47 0.33 3.56e-10 Total body bone mineral density; LUSC cis rs12410462 0.681 rs115959512 chr1:227599578 T/C cg10327440 chr1:227177885 CDC42BPA -0.7 -5.98 -0.31 5.61e-9 Major depressive disorder; LUSC cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg27446573 chr6:127587934 RNF146 0.92 15.32 0.64 1.7e-40 Breast cancer; LUSC cis rs35771425 0.619 rs6689078 chr1:211476423 C/G cg25617285 chr1:211431773 RCOR3 -0.38 -5.74 -0.3 2.15e-8 Educational attainment (years of education); LUSC cis rs1691799 0.899 rs1060724 chr12:66740444 T/C cg16791601 chr12:66731901 HELB -0.71 -12.65 -0.57 3.03e-30 White blood cell count (basophil); LUSC cis rs9952991 0.941 rs7237497 chr18:12777325 T/C cg23544223 chr18:12777786 NA 0.59 6.27 0.32 1.15e-9 Inflammatory skin disease; LUSC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg11812906 chr14:75593930 NEK9 0.55 8.61 0.43 2.96e-16 Height; LUSC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg12826209 chr6:26865740 GUSBL1 0.73 8.92 0.44 3.1e-17 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9814567 1.000 rs7428326 chr3:134251184 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg03709012 chr19:19516395 GATAD2A -0.83 -13.84 -0.6 9.33e-35 Tonsillectomy; LUSC cis rs6754311 0.681 rs4954493 chr2:136609975 T/C cg15123519 chr2:136567270 LCT 0.39 5.99 0.31 5.49e-9 Mosquito bite size; LUSC cis rs12681288 0.862 rs2600487 chr8:1016903 C/T cg15309053 chr8:964076 NA 0.36 7.1 0.36 7.6e-12 Schizophrenia; LUSC cis rs6500395 1.000 rs904818 chr16:48622582 T/C cg04672837 chr16:48644449 N4BP1 0.5 7.42 0.38 9.53e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7568458 0.811 rs10175792 chr2:85761654 A/G cg23752985 chr2:85803571 VAMP8 0.3 6.39 0.33 5.45e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg19875535 chr5:140030758 IK -0.53 -8.78 -0.43 8.59e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg27494647 chr7:150038898 RARRES2 0.44 6.84 0.35 3.85e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs548181 0.545 rs76179820 chr11:125616379 A/G cg03464685 chr11:125439445 EI24 -0.92 -10.98 -0.51 3.76e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9888739 1.000 rs11865746 chr16:31326587 T/G cg15817542 chr16:31343056 ITGAM -0.51 -6.12 -0.32 2.58e-9 Systemic lupus erythematosus; LUSC cis rs12760731 0.720 rs7524556 chr1:178446659 C/T cg00404053 chr1:178313656 RASAL2 0.56 6.17 0.32 1.99e-9 Obesity-related traits; LUSC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg22532475 chr10:104410764 TRIM8 -0.39 -8.14 -0.41 8.16e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg16339924 chr4:17578868 LAP3 0.55 8.48 0.42 7.61e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2302729 1.000 rs2302729 chr12:2783972 T/C cg19945202 chr12:2788847 CACNA1C -0.4 -5.71 -0.3 2.54e-8 Sleep quality; LUSC cis rs259282 0.562 rs2021772 chr19:33107651 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.65 9.64 0.47 1.49e-19 Schizophrenia; LUSC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg01652190 chr22:50026171 C22orf34 -0.32 -6.68 -0.34 1.02e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg27446573 chr6:127587934 RNF146 0.9 14.73 0.63 3.34e-38 Breast cancer; LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg25767906 chr1:53392781 SCP2 0.47 8.41 0.42 1.22e-15 Monocyte count; LUSC cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 20.33 0.74 2.23e-60 Cognitive ability; LUSC cis rs709400 0.633 rs7160208 chr14:103965528 G/A cg10523860 chr14:103875565 MARK3 -0.36 -5.8 -0.3 1.54e-8 Body mass index; LUSC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg13126279 chr21:47581558 C21orf56 -0.46 -6.82 -0.35 4.36e-11 Testicular germ cell tumor; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07761912 chr1:179846929 TOR1AIP2 0.44 7.35 0.37 1.52e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7178572 0.789 rs4886869 chr15:77799657 A/G cg22256960 chr15:77711686 NA -0.4 -6.44 -0.33 4.25e-10 Type 2 diabetes; LUSC cis rs6076065 0.723 rs6083119 chr20:23390923 T/G cg11657817 chr20:23433608 CST11 0.43 8.09 0.4 1.1e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg22782873 chr19:19639568 YJEFN3 -0.49 -6.12 -0.32 2.56e-9 Bipolar disorder; LUSC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg21545522 chr1:205238299 TMCC2 0.5 9.35 0.46 1.32e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1577917 0.739 rs6922 chr6:86205323 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 10.57 0.5 9.82e-23 Response to antipsychotic treatment; LUSC cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg04450456 chr4:17643702 FAM184B 0.37 6.08 0.32 3.3e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.19 -0.52 6.71e-25 Mean corpuscular volume; LUSC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg14440974 chr22:39074834 NA -0.36 -5.83 -0.3 1.31e-8 Menopause (age at onset); LUSC cis rs2290416 0.892 rs62522165 chr8:144675379 C/T cg14809332 chr8:144654887 C8orf73 0.54 6.53 0.34 2.41e-10 Attention deficit hyperactivity disorder; LUSC cis rs2486288 0.656 rs8039352 chr15:45551790 A/G cg26924012 chr15:45694286 SPATA5L1 -0.7 -10.11 -0.48 3.89e-21 Glomerular filtration rate; LUSC cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg25427524 chr10:38739819 LOC399744 -0.57 -10.04 -0.48 6.85e-21 Extrinsic epigenetic age acceleration; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg11645453 chr3:52864694 ITIH4 0.4 8.73 0.43 1.26e-16 Bipolar disorder; LUSC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.71 -0.34 8.54e-11 Lung cancer; LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg01802117 chr1:53393560 SCP2 0.38 6.25 0.32 1.22e-9 Monocyte count; LUSC cis rs6977660 0.660 rs12531278 chr7:19816439 A/T cg05791153 chr7:19748676 TWISTNB 0.68 7.22 0.37 3.49e-12 Thyroid stimulating hormone; LUSC trans rs10090774 0.965 rs10111363 chr8:141928350 A/C cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.29 6.13 0.32 2.51e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg24154853 chr7:158122151 PTPRN2 0.44 8.65 0.43 2.2e-16 Calcium levels; LUSC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg10057126 chr4:77819792 ANKRD56 0.54 8.04 0.4 1.56e-14 Emphysema distribution in smoking; LUSC trans rs60843830 1.000 rs62114544 chr2:269679 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.35 0.49 5.71e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7523273 0.606 rs2488253 chr1:207938709 C/A cg22525895 chr1:207977042 MIR29B2 0.41 6.69 0.34 9.54e-11 Schizophrenia; LUSC cis rs6693567 0.565 rs12093148 chr1:150265173 G/A cg15654264 chr1:150340011 RPRD2 -0.45 -7.03 -0.36 1.14e-11 Migraine; LUSC trans rs877282 0.898 rs36064821 chr10:760952 C/T cg13042288 chr15:90349979 ANPEP -0.43 -6.23 -0.32 1.42e-9 Uric acid levels; LUSC cis rs9487051 1.000 rs13191948 chr6:109634599 C/T cg00509249 chr6:109615579 CCDC162 -0.34 -6.04 -0.31 4.02e-9 Reticulocyte fraction of red cells; LUSC cis rs11122272 0.735 rs2437147 chr1:231516756 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs7824557 0.510 rs1435274 chr8:11235910 G/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.77 -0.3 1.8e-8 Retinal vascular caliber; LUSC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg21433313 chr16:3507492 NAT15 -0.66 -10.82 -0.51 1.4e-23 Tuberculosis; LUSC cis rs7107174 1.000 rs1942352 chr11:77970563 T/G cg02023728 chr11:77925099 USP35 0.51 7.49 0.38 6.27e-13 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.88e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.47 -7.02 -0.36 1.27e-11 Alzheimer's disease (late onset); LUSC cis rs950169 0.922 rs4842940 chr15:84831225 C/T cg17173187 chr15:85201210 NMB -0.37 -6.7 -0.34 8.96e-11 Schizophrenia; LUSC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg06238570 chr21:40685208 BRWD1 0.45 6.94 0.36 2.04e-11 Cognitive function; LUSC trans rs62238980 0.614 rs10483163 chr22:32459451 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs483180 0.512 rs598685 chr1:120215269 G/A cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.4e-10 Macular telangiectasia type 2; LUSC cis rs3540 0.533 rs12708585 chr15:91052285 C/T cg22089800 chr15:90895588 ZNF774 -0.63 -9.39 -0.46 9.86e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6704644 0.651 rs3820744 chr2:234361548 T/C cg05711037 chr2:234359783 DGKD 0.63 6.71 0.34 8.33e-11 Bilirubin levels; LUSC cis rs2762353 0.935 rs3799340 chr6:25762646 C/T cg12310025 chr6:25882481 NA 0.44 7.46 0.38 7.36e-13 Blood metabolite levels; LUSC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg22244940 chr12:132335942 MMP17 0.41 5.96 0.31 6.36e-9 Migraine; LUSC cis rs1866706 1.000 rs11022517 chr11:12884855 G/A cg25843174 chr11:12811716 TEAD1 0.29 5.65 0.3 3.36e-8 Intelligence (multi-trait analysis); LUSC cis rs950776 0.518 rs12903129 chr15:78819606 C/T cg22563815 chr15:78856949 CHRNA5 0.26 6.33 0.33 8.12e-10 Sudden cardiac arrest; LUSC cis rs6445797 0.692 rs28407059 chr3:56566036 C/T cg13792233 chr3:56591045 CCDC66 0.42 5.65 0.3 3.38e-8 Gastritis; LUSC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg20607287 chr7:12443886 VWDE -0.65 -6.42 -0.33 4.74e-10 Coronary artery disease; LUSC cis rs7264396 0.690 rs2425175 chr20:34445563 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.53 -0.42 5.25e-16 Total cholesterol levels; LUSC cis rs2797685 1.000 rs2640908 chr1:7889941 C/T cg04725166 chr1:7887271 PER3 -0.45 -6.34 -0.33 7.27e-10 Crohn's disease; LUSC cis rs9467773 0.804 rs2073526 chr6:26374658 C/T cg05738196 chr6:26577821 NA -0.53 -8.37 -0.42 1.57e-15 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg04450456 chr4:17643702 FAM184B 0.37 6.3 0.33 9.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12908161 1.000 rs17600551 chr15:85319258 A/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.62 0.34 1.42e-10 Schizophrenia; LUSC cis rs10450586 0.897 rs28416407 chr11:27308244 G/T cg08958251 chr11:27270390 NA 0.36 5.93 0.31 7.37e-9 Total body bone mineral density; LUSC cis rs7824557 0.583 rs2263511 chr8:11233318 A/C cg21775007 chr8:11205619 TDH -0.68 -10.68 -0.5 4.35e-23 Retinal vascular caliber; LUSC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.88 -0.31 9.76e-9 Life satisfaction; LUSC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg22105103 chr4:187893119 NA 0.71 13.88 0.6 6.72e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.32e-11 Tonsillectomy; LUSC trans rs4650994 0.507 rs12141152 chr1:178514165 C/T cg05059571 chr16:84539110 KIAA1609 -0.46 -8.63 -0.43 2.48e-16 HDL cholesterol levels;HDL cholesterol; LUSC trans rs61931739 0.500 rs11053290 chr12:34582392 C/T cg13010199 chr12:38710504 ALG10B -0.57 -8.91 -0.44 3.41e-17 Morning vs. evening chronotype; LUSC cis rs2717559 0.542 rs2717590 chr8:143900712 A/G cg02415014 chr8:143852576 LYNX1 0.34 7.9 0.4 4.05e-14 Urinary tract infection frequency; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22162225 chr2:62932835 EHBP1 -0.5 -6.07 -0.32 3.5e-9 Bipolar disorder and schizophrenia; LUSC cis rs9916302 0.561 rs12453198 chr17:37741879 T/C cg07936489 chr17:37558343 FBXL20 -0.63 -7.52 -0.38 5.16e-13 Glomerular filtration rate (creatinine); LUSC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg12311346 chr5:56204834 C5orf35 -0.57 -8.69 -0.43 1.62e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs6121246 0.909 rs7272062 chr20:30259145 A/G cg13852791 chr20:30311386 BCL2L1 0.89 12.01 0.55 7.13e-28 Mean corpuscular hemoglobin; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg04025307 chr7:1156635 C7orf50 0.45 6.98 0.36 1.6e-11 Longevity;Endometriosis; LUSC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg19592336 chr6:28129416 ZNF389 0.47 6.48 0.33 3.39e-10 Parkinson's disease; LUSC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg25036284 chr2:26402008 FAM59B -0.67 -9.23 -0.45 3.29e-18 Gut microbiome composition (summer); LUSC cis rs9790314 0.875 rs336582 chr3:161082659 C/T cg03342759 chr3:160939853 NMD3 -0.49 -8.17 -0.41 6.3e-15 Morning vs. evening chronotype; LUSC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg23283495 chr1:209979779 IRF6 0.45 7.19 0.37 4.37e-12 Monobrow; LUSC cis rs6977660 0.660 rs10224938 chr7:19816227 A/G cg05791153 chr7:19748676 TWISTNB 0.69 7.25 0.37 2.85e-12 Thyroid stimulating hormone; LUSC cis rs10504073 0.584 rs4873300 chr8:49902201 C/G cg00325661 chr8:49890786 NA 0.7 11.14 0.52 1.04e-24 Blood metabolite ratios; LUSC cis rs877282 1.000 rs11253362 chr10:770979 G/T cg17470449 chr10:769945 NA 0.55 7.85 0.39 5.77e-14 Uric acid levels; LUSC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg16434002 chr17:42200994 HDAC5 0.44 5.86 0.31 1.1e-8 Total body bone mineral density; LUSC cis rs2540226 0.569 rs6717356 chr2:40051216 C/T cg23576258 chr2:39999331 THUMPD2 -0.34 -5.68 -0.3 2.93e-8 Personality dimensions; LUSC cis rs950776 0.518 rs2869055 chr15:78822388 G/C cg22563815 chr15:78856949 CHRNA5 -0.25 -5.96 -0.31 6.58e-9 Sudden cardiac arrest; LUSC trans rs9380880 0.826 rs2273062 chr6:39550935 C/A cg12580580 chr10:74544059 CCDC109A 0.59 6.68 0.34 9.96e-11 Immune response to smallpox vaccine (IL-6); LUSC cis rs11122272 0.701 rs11582413 chr1:231530098 C/G cg06096015 chr1:231504339 EGLN1 0.58 10.45 0.5 2.68e-22 Hemoglobin concentration; LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg01879757 chr17:41196368 BRCA1 -0.46 -6.94 -0.35 2.08e-11 Menopause (age at onset); LUSC cis rs11587400 0.634 rs4839385 chr1:115121461 A/G cg12756093 chr1:115239321 AMPD1 0.42 6.32 0.33 8.35e-10 Autism; LUSC cis rs2295359 0.892 rs11209005 chr1:67618678 A/G cg12940439 chr1:67600707 NA 0.36 6.04 0.31 4.17e-9 Psoriasis; LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg21782813 chr7:2030301 MAD1L1 0.53 9.27 0.45 2.38e-18 Bipolar disorder and schizophrenia; LUSC cis rs6500602 0.627 rs863501 chr16:4588394 G/C cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.44 -6.5 -0.34 2.96e-10 Schizophrenia; LUSC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg00343986 chr7:65444356 GUSB 0.44 6.8 0.35 4.95e-11 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04824553 chr4:103748367 UBE2D3 -0.42 -6.28 -0.32 1.08e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6076960 0.684 rs6054055 chr20:6257517 C/G cg21095983 chr6:86352623 SYNCRIP 0.53 8.35 0.42 1.85e-15 Smooth-surface caries; LUSC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg24531977 chr5:56204891 C5orf35 -1.04 -15.25 -0.64 3.19e-40 Initial pursuit acceleration; LUSC cis rs7178572 0.889 rs11857450 chr15:77802791 C/G cg22256960 chr15:77711686 NA 0.5 8.32 0.41 2.3e-15 Type 2 diabetes; LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg00149659 chr3:10157352 C3orf10 1.0 14.38 0.62 7.83e-37 Alzheimer's disease; LUSC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg26513180 chr16:89883248 FANCA 0.91 17.71 0.7 5.61e-50 Vitiligo; LUSC cis rs733592 0.507 rs7138917 chr12:48455255 G/A cg24011408 chr12:48396354 COL2A1 -0.51 -8.37 -0.42 1.6e-15 Plateletcrit; LUSC cis rs2282300 0.739 rs10742237 chr11:30310659 C/T cg25418670 chr11:30344373 C11orf46 0.64 9.15 0.45 5.83e-18 Morning vs. evening chronotype; LUSC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg09491104 chr22:46646882 C22orf40 -0.66 -6.9 -0.35 2.55e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg13798912 chr7:905769 UNC84A -0.56 -5.89 -0.31 9.24e-9 Cerebrospinal P-tau181p levels; LUSC cis rs3772130 1.000 rs7427165 chr3:121364624 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.66 9.37 0.46 1.1e-18 Cognitive performance; LUSC cis rs6728642 0.572 rs13403225 chr2:97600827 A/G cg26665480 chr2:98280029 ACTR1B -0.71 -7.4 -0.38 1.14e-12 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00890378 chr1:33816159 PHC2 0.7 6.01 0.31 4.82e-9 Cognitive performance; LUSC cis rs2637266 0.745 rs2583039 chr10:78440187 A/G cg18941641 chr10:78392320 NA 0.35 6.34 0.33 7.66e-10 Pulmonary function; LUSC cis rs10760158 0.865 rs10739594 chr9:124035380 A/G cg14417974 chr9:124058376 GSN -0.32 -5.79 -0.3 1.63e-8 Pulse pressure; LUSC cis rs12541635 0.737 rs736627 chr8:107100285 C/T cg10147462 chr8:107024639 NA -0.41 -7.34 -0.37 1.65e-12 Age of smoking initiation; LUSC cis rs2760061 0.583 rs708121 chr1:228208257 A/G cg04850211 chr1:228464232 OBSCN -0.36 -6.12 -0.32 2.56e-9 Diastolic blood pressure; LUSC cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg07828340 chr4:882639 GAK 1.1 11.94 0.55 1.33e-27 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.38 -0.42 1.51e-15 Lung cancer; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg22963979 chr7:1858916 MAD1L1 -0.6 -9.44 -0.46 6.63e-19 Bipolar disorder and schizophrenia; LUSC cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg25208724 chr1:156163844 SLC25A44 1.1 27.11 0.83 2.32e-86 Testicular germ cell tumor; LUSC cis rs939658 0.728 rs12904789 chr15:79412589 G/A cg17916960 chr15:79447300 NA -0.48 -9.02 -0.44 1.45e-17 Refractive error; LUSC trans rs28735056 0.933 rs499260 chr18:77589689 G/A cg05926928 chr17:57297772 GDPD1 -0.48 -6.71 -0.34 8.57e-11 Schizophrenia; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg07602492 chr1:72750241 NA 0.41 6.38 0.33 5.81e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6456156 0.586 rs12528689 chr6:167461746 A/G cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.21 -0.37 3.73e-12 Height; LUSC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg06494592 chr3:125709126 NA -0.5 -5.7 -0.3 2.61e-8 Blood pressure (smoking interaction); LUSC cis rs1577917 1.000 rs12154056 chr6:86634094 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg10729496 chr3:10149963 C3orf24 0.57 7.42 0.38 9.8e-13 Alzheimer's disease; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg02475777 chr4:1388615 CRIPAK 0.38 5.77 0.3 1.82e-8 Obesity-related traits; LUSC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Vitiligo; LUSC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs6480314 0.542 rs4403687 chr10:70028052 A/G cg04882175 chr6:131122610 NA -0.52 -6.2 -0.32 1.67e-9 Optic nerve measurement (disc area); LUSC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg14668632 chr7:2872130 GNA12 -0.44 -6.37 -0.33 6.4e-10 Height; LUSC cis rs8180040 0.932 rs1038394 chr3:47464122 A/G cg02527881 chr3:46936655 PTH1R -0.38 -6.74 -0.35 7.06e-11 Colorectal cancer; LUSC cis rs7113850 0.541 rs7928230 chr11:24220604 A/G ch.11.24196551F chr11:24239977 NA 0.99 8.89 0.44 3.77e-17 Bone fracture in osteoporosis; LUSC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg09359103 chr1:154839909 KCNN3 -0.69 -15.84 -0.65 1.53e-42 Prostate cancer; LUSC cis rs116095464 0.558 rs6866632 chr5:264429 C/G cg22496380 chr5:211416 CCDC127 -0.79 -9.25 -0.45 2.68e-18 Breast cancer; LUSC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.84 0.63 1.31e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.09 0.32 3.15e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10484885 0.648 rs2777848 chr6:90535993 G/A cg13799429 chr6:90582589 CASP8AP2 -0.98 -13.61 -0.6 7.15e-34 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9311676 0.632 rs56026131 chr3:58422483 C/G cg26110898 chr3:58419937 PDHB 0.4 6.39 0.33 5.46e-10 Systemic lupus erythematosus; LUSC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg25036284 chr2:26402008 FAM59B 0.65 8.63 0.43 2.5e-16 Gut microbiome composition (summer); LUSC cis rs11190604 1.000 rs79831012 chr10:102237059 T/C cg07080220 chr10:102295463 HIF1AN 0.64 8.46 0.42 8.63e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg19539972 chr4:7069911 GRPEL1 0.7 9.04 0.44 1.28e-17 Monocyte percentage of white cells; LUSC cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg08999081 chr20:33150536 PIGU 0.48 9.39 0.46 9.68e-19 Coronary artery disease; LUSC cis rs3862435 0.706 rs10520686 chr15:90997429 C/G cg22089800 chr15:90895588 ZNF774 0.56 5.95 0.31 6.67e-9 Response to exercise (triglyceride level interaction); LUSC cis rs4242434 0.672 rs10113779 chr8:22485934 G/C cg03733263 chr8:22462867 KIAA1967 0.78 12.37 0.56 3.4e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs3755132 0.929 rs16862838 chr2:15788191 A/G cg12888861 chr2:15731646 DDX1 -0.49 -7.26 -0.37 2.65e-12 Wilms tumor; LUSC cis rs7917772 0.582 rs10883744 chr10:104347247 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg13010199 chr12:38710504 ALG10B 0.69 10.76 0.51 2.14e-23 Morning vs. evening chronotype; LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg19626725 chr5:178986131 RUFY1 -0.6 -10.43 -0.5 3.19e-22 Lung cancer; LUSC cis rs7598759 0.712 rs6727372 chr2:232331906 T/G cg19187155 chr2:232395269 NMUR1 0.49 7.2 0.37 3.99e-12 Noise-induced hearing loss; LUSC cis rs3750965 0.734 rs11604251 chr11:68820429 A/G cg06818126 chr11:68850279 TPCN2 0.43 6.19 0.32 1.81e-9 Hair color; LUSC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg19717773 chr7:2847554 GNA12 -0.34 -5.73 -0.3 2.22e-8 Height; LUSC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg11861562 chr11:117069780 TAGLN 0.45 8.25 0.41 3.7e-15 Blood protein levels; LUSC cis rs2439831 0.681 rs3742971 chr15:43622916 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -1.06 -14.62 -0.62 8.84e-38 Lung cancer in ever smokers; LUSC cis rs2797160 0.967 rs8180614 chr6:126000599 G/C cg05901451 chr6:126070800 HEY2 -0.58 -8.7 -0.43 1.5e-16 Endometrial cancer; LUSC cis rs9611565 0.649 rs139559 chr22:42191636 A/G cg17376030 chr22:41985996 PMM1 0.43 5.9 0.31 9.1e-9 Vitiligo; LUSC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.69 12.4 0.56 2.59e-29 Multiple sclerosis; LUSC cis rs2348418 0.864 rs7136843 chr12:28717808 C/G cg13890972 chr12:28721907 NA -0.34 -5.93 -0.31 7.72e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs17685 0.884 rs8565 chr7:75630274 T/C cg16489192 chr7:75678113 MDH2;STYXL1 0.45 6.65 0.34 1.16e-10 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs17102423 0.826 rs17825846 chr14:65598752 C/G cg11161011 chr14:65562177 MAX -0.67 -10.4 -0.49 4.08e-22 Obesity-related traits; LUSC cis rs2267681 0.603 rs2267679 chr7:139539218 C/T cg14116596 chr7:139528673 TBXAS1 0.38 6.57 0.34 1.88e-10 Cervical cancer; LUSC cis rs17095355 1.000 rs17095350 chr10:111701708 T/C cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.67 -0.39 1.93e-13 Biliary atresia; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg03354898 chr7:1950403 MAD1L1 -0.34 -6.79 -0.35 5.24e-11 Bipolar disorder and schizophrenia; LUSC trans rs2243480 1.000 rs316329 chr7:65608416 A/C cg10756647 chr7:56101905 PSPH 0.81 8.47 0.42 7.95e-16 Diabetic kidney disease; LUSC cis rs7927771 0.507 rs7119517 chr11:47675316 T/C cg18512352 chr11:47633146 NA 0.28 5.79 0.3 1.62e-8 Subjective well-being; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00986184 chr20:62151995 PPDPF 0.72 6.29 0.33 1.01e-9 Cognitive performance; LUSC cis rs2835872 0.861 rs67739865 chr21:39049101 G/A cg20424643 chr21:39039972 KCNJ6 0.42 6.22 0.32 1.51e-9 Electroencephalographic traits in alcoholism; LUSC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11141652 chr22:24348549 GSTTP1 -0.42 -6.54 -0.34 2.26e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs67072384 0.818 rs12284245 chr11:72477668 C/T cg04827223 chr11:72435913 ARAP1 -0.9 -6.37 -0.33 6.4e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg20821713 chr7:1055600 C7orf50 -0.56 -7.53 -0.38 4.86e-13 Bronchopulmonary dysplasia; LUSC cis rs1577917 0.958 rs11752180 chr6:86573165 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.68 -0.34 9.86e-11 Response to antipsychotic treatment; LUSC cis rs72781680 0.715 rs72796332 chr2:24142060 G/A cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg07414643 chr4:187882934 NA 0.57 10.82 0.51 1.36e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs977987 0.806 rs34021527 chr16:75474090 A/G cg04384234 chr16:75411784 CFDP1 -0.43 -7.11 -0.36 6.95e-12 Dupuytren's disease; LUSC cis rs7851660 0.809 rs7032114 chr9:100656459 T/G cg13688889 chr9:100608707 NA -0.54 -8.42 -0.42 1.12e-15 Strep throat; LUSC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.47 -5.69 -0.3 2.83e-8 Schizophrenia; LUSC trans rs445114 0.509 rs432523 chr8:128337927 A/T cg10897648 chr18:56338258 MALT1 -0.42 -6.33 -0.33 8.12e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs2200578 0.836 rs72957179 chr2:99693578 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.64 7.59 0.38 3.21e-13 IgG glycosylation; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -8.94 -0.44 2.67e-17 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg08677398 chr8:58056175 NA 0.57 6.89 0.35 2.79e-11 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg11645453 chr3:52864694 ITIH4 0.33 7.6 0.38 3.08e-13 Bipolar disorder; LUSC cis rs7089973 0.872 rs7072356 chr10:116634651 T/C cg23260525 chr10:116636907 FAM160B1 0.39 7.99 0.4 2.19e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9300255 0.722 rs1060105 chr12:123806219 C/T cg13010344 chr12:123464640 ARL6IP4 0.5 6.21 0.32 1.58e-9 Neutrophil percentage of white cells; LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg14092988 chr3:52407081 DNAH1 0.31 6.09 0.32 3.04e-9 Bipolar disorder; LUSC cis rs12801636 0.846 rs1078457 chr11:65380124 C/T cg24468199 chr11:65410028 SIPA1 -0.53 -6.95 -0.36 1.93e-11 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg25019033 chr10:957182 NA -0.52 -7.05 -0.36 1.02e-11 Eosinophil percentage of granulocytes; LUSC cis rs240764 0.658 rs846803 chr6:101272801 C/T cg09795085 chr6:101329169 ASCC3 -0.45 -6.65 -0.34 1.19e-10 Neuroticism; LUSC cis rs4737010 0.959 rs4737009 chr8:41630405 A/G cg17182837 chr8:41585554 ANK1 -0.36 -6.53 -0.34 2.5e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05732436 chr2:68290174 C1D -0.39 -6.07 -0.32 3.49e-9 Electrocardiographic conduction measures; LUSC cis rs2439831 0.681 rs28594657 chr15:43588888 C/A cg02155558 chr15:43621948 ADAL;LCMT2 1.16 14.74 0.63 3.26e-38 Lung cancer in ever smokers; LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg13397359 chr6:42928475 GNMT 0.64 10.66 0.5 5.13e-23 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9902453 0.967 rs9904336 chr17:28357080 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg01028140 chr2:1542097 TPO -0.52 -8.45 -0.42 9.07e-16 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg11645453 chr3:52864694 ITIH4 0.34 8.08 0.4 1.21e-14 Electroencephalogram traits; LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.11 -0.32 2.76e-9 Developmental language disorder (linguistic errors); LUSC cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg03146154 chr1:46216737 IPP -0.52 -7.39 -0.37 1.21e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03517284 chr6:25882590 NA -0.59 -10.49 -0.5 1.97e-22 Blood metabolite levels; LUSC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.85 0.47 3e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2486288 0.656 rs11629858 chr15:45547114 T/C cg04036182 chr15:45458818 NA -0.36 -5.73 -0.3 2.22e-8 Glomerular filtration rate; LUSC cis rs11098499 0.780 rs12504773 chr4:120562149 G/C cg09307838 chr4:120376055 NA 0.73 10.21 0.49 1.75e-21 Corneal astigmatism; LUSC cis rs300890 0.513 rs4277733 chr4:144048046 A/G cg19326217 chr4:144171750 NA 0.39 5.94 0.31 7.33e-9 Nasopharyngeal carcinoma; LUSC cis rs6961069 0.573 rs10268765 chr7:80240073 C/G cg04458919 chr7:80252533 CD36 -0.4 -7.28 -0.37 2.39e-12 Platelet count; LUSC cis rs208520 0.545 rs10944874 chr6:66752080 C/T cg07460842 chr6:66804631 NA -1.16 -23.13 -0.78 2.51e-71 Exhaled nitric oxide output; LUSC trans rs853679 0.517 rs9368555 chr6:28108967 T/C cg06606381 chr12:133084897 FBRSL1 -0.45 -5.95 -0.31 6.74e-9 Depression; LUSC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg08219700 chr8:58056026 NA 0.69 8.07 0.4 1.27e-14 Developmental language disorder (linguistic errors); LUSC cis rs2219968 0.962 rs13266874 chr8:78946400 T/C cg00738934 chr8:78996279 NA 0.37 6.63 0.34 1.3100000000000001e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7264396 0.887 rs224392 chr20:34107956 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.22 -0.32 1.48e-9 Total cholesterol levels; LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg22166914 chr1:53195759 ZYG11B 0.56 9.12 0.45 6.96e-18 Monocyte count; LUSC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs12677618 1.000 rs10092931 chr8:142307201 A/G cg27411547 chr8:142287226 NA -0.4 -6.69 -0.34 9.66e-11 Plateletcrit; LUSC cis rs60695258 0.550 rs340641 chr4:87951393 C/T cg10685359 chr4:87814065 C4orf36 0.34 5.99 0.31 5.47e-9 Hematocrit; LUSC cis rs4820294 1.000 rs4820294 chr22:38071043 G/A cg21798802 chr22:38057573 PDXP 0.48 10.51 0.5 1.6400000000000001e-22 Fat distribution (HIV); LUSC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg13628971 chr7:2884303 GNA12 0.4 6.0 0.31 5.19e-9 Height; LUSC cis rs113835537 0.529 rs4930379 chr11:66255674 G/A cg24851651 chr11:66362959 CCS 0.54 8.02 0.4 1.77e-14 Airway imaging phenotypes; LUSC cis rs739401 0.572 rs389285 chr11:3062673 G/A cg05729581 chr11:3078854 CARS -0.56 -8.42 -0.42 1.1e-15 Longevity; LUSC cis rs1865760 0.534 rs2032444 chr6:26046744 T/G cg17691542 chr6:26056736 HIST1H1C 0.66 9.56 0.46 2.75e-19 Height; LUSC cis rs4654899 0.865 rs6691824 chr1:21417577 T/G cg01072550 chr1:21505969 NA -0.48 -7.1 -0.36 7.67e-12 Superior frontal gyrus grey matter volume; LUSC cis rs2439831 1.000 rs2245054 chr15:43751909 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs1403694 0.695 rs10937266 chr3:186433075 G/A cg12454167 chr3:186435060 KNG1 0.34 8.42 0.42 1.1e-15 Blood protein levels; LUSC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 12.49 0.56 1.27e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6089829 0.925 rs6122087 chr20:61664553 T/C cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs67460515 0.500 rs9860537 chr3:160660500 G/T cg03342759 chr3:160939853 NMD3 0.48 6.68 0.34 9.74e-11 Parkinson's disease; LUSC trans rs16848425 1.000 rs16848442 chr4:73526180 T/C cg15289899 chr11:2397255 CD81 0.67 5.95 0.31 6.78e-9 Height; LUSC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg11366901 chr6:160182831 ACAT2 0.93 12.7 0.57 1.98e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs13385 0.769 rs4912707 chr5:139624461 A/G cg26211634 chr5:139558579 C5orf32 0.47 7.18 0.37 4.7e-12 Atrial fibrillation; LUSC cis rs12594515 1.000 rs8043291 chr15:45996247 T/A cg06207120 chr15:45996521 NA 0.39 5.86 0.31 1.11e-8 Waist circumference;Weight; LUSC cis rs12200782 0.932 rs12212145 chr6:26646418 T/A cg11502198 chr6:26597334 ABT1 -0.74 -5.77 -0.3 1.8e-8 Small cell lung carcinoma; LUSC cis rs6456156 0.586 rs7761977 chr6:167485678 A/G cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs394563 0.967 rs438852 chr6:149794533 C/T cg07828024 chr6:149772892 ZC3H12D 0.3 6.56 0.34 2.1e-10 Dupuytren's disease; LUSC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg00310523 chr12:86230176 RASSF9 -0.46 -8.8 -0.43 7.25e-17 Major depressive disorder; LUSC cis rs7089973 0.872 rs12773943 chr10:116631184 G/A cg23260525 chr10:116636907 FAM160B1 0.39 7.99 0.4 2.29e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7267979 0.816 rs405822 chr20:25501314 A/G cg03522245 chr20:25566470 NINL 0.35 5.74 0.3 2.15e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg05368731 chr17:41323189 NBR1 0.92 15.4 0.64 8.61e-41 Menopause (age at onset); LUSC cis rs7089973 0.872 rs11818115 chr10:116634891 G/A cg23260525 chr10:116636907 FAM160B1 0.39 7.99 0.4 2.19e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9398803 0.830 rs1415671 chr6:126759587 T/G cg19875578 chr6:126661172 C6orf173 0.42 6.14 0.32 2.33e-9 Male-pattern baldness; LUSC cis rs193541 0.632 rs10037044 chr5:122123299 A/G cg19077854 chr5:122220652 SNX24 -0.39 -8.12 -0.41 8.99e-15 Glucose homeostasis traits; LUSC cis rs2835872 0.758 rs1709832 chr21:39038167 A/C cg20424643 chr21:39039972 KCNJ6 -0.44 -6.87 -0.35 3.18e-11 Electroencephalographic traits in alcoholism; LUSC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -12.69 -0.57 2.27e-30 Hemoglobin concentration; LUSC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg14983838 chr19:29218262 NA 0.66 9.24 0.45 3.02e-18 Methadone dose in opioid dependence; LUSC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg03060546 chr3:49711283 APEH 0.71 11.84 0.54 3.09e-27 Resting heart rate; LUSC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg20302533 chr7:39170763 POU6F2 0.52 8.63 0.43 2.51e-16 IgG glycosylation; LUSC cis rs4664304 0.772 rs12692572 chr2:160743793 G/A cg23995753 chr2:160760732 LY75 0.32 6.07 0.32 3.41e-9 Crohn's disease;Inflammatory bowel disease; LUSC trans rs7726839 0.540 rs72703080 chr5:595238 A/G cg25482853 chr8:67687455 SGK3 1.12 15.31 0.64 1.89e-40 Obesity-related traits; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.33 0.45 1.52e-18 Prudent dietary pattern; LUSC cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg05985134 chr18:33552581 C18orf21 0.51 6.97 0.36 1.73e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6495122 0.630 rs12912343 chr15:75251041 C/G cg14664628 chr15:75095509 CSK -0.51 -7.27 -0.37 2.49e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs1003719 0.715 rs13046581 chr21:38551985 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.59e-22 Eye color traits; LUSC cis rs11098499 0.909 rs11723839 chr4:120299673 G/A cg24375607 chr4:120327624 NA 0.76 10.98 0.52 3.7e-24 Corneal astigmatism; LUSC trans rs6951245 1.000 rs80094748 chr7:1103958 G/A cg13565492 chr6:43139072 SRF -0.62 -6.47 -0.33 3.57e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2235642 0.671 rs2235641 chr16:1608177 A/G cg03034668 chr16:1723424 CRAMP1L -0.38 -5.71 -0.3 2.52e-8 Coronary artery disease; LUSC cis rs2124969 0.506 rs10497210 chr2:160985549 G/A cg03641300 chr2:160917029 PLA2R1 -0.47 -5.66 -0.3 3.21e-8 Waist circumference adjusted for body mass index; LUSC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg00825309 chr19:58991885 ZNF446 -0.84 -13.27 -0.59 1.45e-32 Mean platelet volume; LUSC cis rs10779751 0.770 rs11585553 chr1:11233814 G/A cg08854313 chr1:11322531 MTOR -0.83 -12.18 -0.55 1.74e-28 Body mass index; LUSC cis rs1691799 0.867 rs1039056 chr12:66760391 C/T cg16791601 chr12:66731901 HELB -0.68 -11.99 -0.55 8.92e-28 White blood cell count (basophil); LUSC cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.19 0.37 4.4e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg24642844 chr7:1081250 C7orf50 -0.46 -7.32 -0.37 1.92e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg03538708 chr1:25844672 NA -0.39 -6.35 -0.33 6.94e-10 Erythrocyte sedimentation rate; LUSC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg26597838 chr10:835615 NA 1.23 16.83 0.68 1.93e-46 Eosinophil percentage of granulocytes; LUSC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg07936489 chr17:37558343 FBXL20 -0.7 -9.7 -0.47 9.12e-20 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg18404041 chr3:52824283 ITIH1 -0.57 -11.01 -0.52 2.85e-24 Bipolar disorder; LUSC cis rs11122272 0.735 rs2808603 chr1:231537738 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.24 -0.49 1.4e-21 Hemoglobin concentration; LUSC cis rs10791097 0.653 rs11222362 chr11:130731425 T/C cg12179176 chr11:130786555 SNX19 0.76 12.34 0.56 4.43e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg04369109 chr6:150039330 LATS1 -0.53 -7.6 -0.38 3.01e-13 Lung cancer; LUSC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg21984481 chr17:79567631 NPLOC4 -0.57 -10.9 -0.51 7.43e-24 Eye color traits; LUSC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg23262073 chr20:60523788 NA -0.42 -6.04 -0.31 4.06e-9 Body mass index; LUSC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg17366294 chr4:99064904 C4orf37 -0.56 -10.17 -0.49 2.4e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4803468 1.000 rs10417997 chr19:41902361 G/A cg09537434 chr19:41945824 ATP5SL -0.89 -16.01 -0.66 3.4e-43 Height; LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg20887711 chr4:1340912 KIAA1530 0.58 9.09 0.45 9.12e-18 Longevity; LUSC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs17818399 0.962 rs7565274 chr2:46841861 G/T cg02822958 chr2:46747628 ATP6V1E2 0.41 6.4 0.33 5.29e-10 Height; LUSC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg17366294 chr4:99064904 C4orf37 0.57 10.08 0.48 4.8e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs13315871 1.000 rs35621601 chr3:58323174 A/G cg20936604 chr3:58311152 NA -0.77 -7.27 -0.37 2.56e-12 Cholesterol, total; LUSC cis rs7605827 0.930 rs12991640 chr2:15505789 T/C cg19274914 chr2:15703543 NA 0.45 8.51 0.42 6.15e-16 Educational attainment (years of education); LUSC trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg15704280 chr7:45808275 SEPT13 0.86 11.25 0.52 4.21e-25 Coronary artery disease; LUSC cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.25 0.45 2.77e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20679082 chr17:1090548 ABR 0.41 6.25 0.32 1.25e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg17211192 chr8:82754475 SNX16 0.79 10.72 0.51 3.12e-23 Diastolic blood pressure; LUSC cis rs6993244 1 rs6993244 chr8:8863059 C/G cg06636001 chr8:8085503 FLJ10661 0.62 9.63 0.47 1.61e-19 Mean corpuscular hemoglobin; LUSC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg11742103 chr11:62369870 EML3;MTA2 0.54 8.87 0.44 4.42e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4629710 0.568 rs67021539 chr6:131552900 A/G cg12606694 chr6:131520996 AKAP7 0.62 9.4 0.46 9.28e-19 Multiple myeloma (IgH translocation); LUSC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg05425664 chr17:57184151 TRIM37 -0.58 -8.48 -0.42 7.51e-16 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2749717 chr1:231489353 G/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.3e-21 Hemoglobin concentration; LUSC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg06238570 chr21:40685208 BRWD1 -0.62 -10.47 -0.5 2.18e-22 Cognitive function; LUSC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg11764359 chr7:65958608 NA 0.67 10.71 0.51 3.39e-23 Aortic root size; LUSC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg14416269 chr4:6271139 WFS1 0.55 12.22 0.56 1.22e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1395 0.744 rs9653564 chr2:27472618 G/A cg23587288 chr2:27483067 SLC30A3 -0.29 -5.75 -0.3 1.99e-8 Blood metabolite levels; LUSC cis rs4319547 0.619 rs7973869 chr12:122874284 G/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.35 -0.42 1.85e-15 Body mass index; LUSC cis rs977987 0.771 rs12929673 chr16:75470295 C/T cg03315344 chr16:75512273 CHST6 0.5 9.66 0.47 1.22e-19 Dupuytren's disease; LUSC cis rs713477 0.935 rs10144034 chr14:55914273 C/A cg13175173 chr14:55914753 NA -0.31 -6.49 -0.33 3.05e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs2204008 0.570 rs1315664 chr12:38138274 A/G cg13010199 chr12:38710504 ALG10B -0.51 -7.62 -0.38 2.69e-13 Bladder cancer; LUSC cis rs477692 1.000 rs473771 chr10:131408155 A/C cg26102564 chr10:131424627 MGMT 0.45 6.98 0.36 1.58e-11 Response to temozolomide; LUSC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg10556349 chr10:835070 NA 0.55 6.21 0.32 1.53e-9 Eosinophil percentage of granulocytes; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 5.94 0.31 7.34e-9 Lymphocyte counts; LUSC cis rs113835537 0.529 rs2298806 chr11:66282095 G/A cg24851651 chr11:66362959 CCS 0.53 7.93 0.4 3.42e-14 Airway imaging phenotypes; LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg16145915 chr7:1198662 ZFAND2A -0.46 -8.33 -0.41 2.18e-15 Longevity;Endometriosis; LUSC cis rs727505 1.000 rs77718560 chr7:124514544 T/A cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs2795502 1.000 rs2795497 chr10:43339475 C/A cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC cis rs9311676 0.632 rs1126735 chr3:58413408 A/G cg26110898 chr3:58419937 PDHB 0.41 6.52 0.34 2.6e-10 Systemic lupus erythematosus; LUSC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg11245181 chr6:149772854 ZC3H12D 0.3 6.4 0.33 5.29e-10 Dupuytren's disease; LUSC cis rs57221529 0.766 rs12519469 chr5:581772 A/G cg16624210 chr5:671434 TPPP 0.49 6.13 0.32 2.47e-9 Lung disease severity in cystic fibrosis; LUSC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg21963583 chr11:68658836 MRPL21 0.56 8.31 0.41 2.49e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg12016809 chr21:47604291 C21orf56 0.45 6.76 0.35 6.01e-11 Testicular germ cell tumor; LUSC trans rs7613875 0.620 rs7634441 chr3:50071677 G/A cg21659725 chr3:3221576 CRBN -0.52 -8.33 -0.41 2.17e-15 Body mass index; LUSC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg03676636 chr4:99064102 C4orf37 0.36 7.85 0.39 5.64e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1595825 0.891 rs1968488 chr2:198721827 C/A cg10547527 chr2:198650123 BOLL -0.5 -5.91 -0.31 8.37e-9 Ulcerative colitis; LUSC trans rs2288327 0.643 rs16866334 chr2:179336672 A/G cg14011486 chr1:26737247 LIN28 0.85 11.74 0.54 6.95e-27 Atrial fibrillation; LUSC cis rs3806843 1.000 rs2879089 chr5:140191893 A/T cg19875535 chr5:140030758 IK 0.46 7.35 0.37 1.58e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs79839061 0.520 rs6842808 chr4:906903 C/T cg07828340 chr4:882639 GAK 0.96 10.27 0.49 1.12e-21 Intelligence (multi-trait analysis); LUSC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg07716408 chr11:68623521 NA -0.31 -5.96 -0.31 6.4e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs9329221 0.512 rs7843924 chr8:9976540 C/T cg15556689 chr8:8085844 FLJ10661 0.53 7.96 0.4 2.74e-14 Neuroticism; LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg08736216 chr1:53307985 ZYG11A 0.3 6.31 0.33 8.63e-10 Monocyte count; LUSC cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.45 6.2 0.32 1.66e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg02269571 chr22:50332266 NA -0.57 -8.58 -0.42 3.69e-16 Schizophrenia; LUSC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg03929089 chr4:120376271 NA -0.96 -15.5 -0.65 3.22e-41 Coronary artery disease; LUSC cis rs11051970 0.838 rs2651369 chr12:32552769 C/G cg24626660 chr12:32551988 NA 0.33 5.74 0.3 2.08e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6121246 0.559 rs6060932 chr20:30350545 A/G cg13852791 chr20:30311386 BCL2L1 0.95 14.9 0.63 7.51e-39 Mean corpuscular hemoglobin; LUSC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9807989 0.839 rs9308857 chr2:102979624 G/A cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs1448094 0.802 rs11513957 chr12:86435551 C/T cg00310523 chr12:86230176 RASSF9 0.41 7.4 0.38 1.12e-12 Major depressive disorder; LUSC cis rs66887589 0.616 rs1052633 chr4:120215314 A/G cg13609457 chr4:120235615 NA 0.39 6.05 0.31 3.88e-9 Diastolic blood pressure; LUSC cis rs72772090 0.539 rs116360011 chr5:96117797 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.57 -0.34 1.92e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10089 1.000 rs10061367 chr5:127449021 T/C cg19767477 chr5:127420684 SLC12A2 -0.43 -5.87 -0.31 1.06e-8 Ileal carcinoids; LUSC cis rs3126085 0.935 rs2291770 chr1:152179792 G/C cg26876637 chr1:152193138 HRNR 0.42 5.89 0.31 9.39e-9 Atopic dermatitis; LUSC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -10.21 -0.49 1.83e-21 Developmental language disorder (linguistic errors); LUSC trans rs877282 1.000 rs12773872 chr10:771939 T/C cg13042288 chr15:90349979 ANPEP -0.49 -6.82 -0.35 4.39e-11 Uric acid levels; LUSC cis rs883565 0.528 rs11716902 chr3:38958010 G/T cg26331595 chr3:39149181 GORASP1;TTC21A -0.4 -5.81 -0.3 1.5e-8 Handedness; LUSC cis rs3540 0.618 rs11636089 chr15:91039527 C/T cg03599575 chr15:90893182 GABARAPL3 0.33 5.68 0.3 2.91e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.51 0.34 2.73e-10 Menopause (age at onset); LUSC cis rs12908161 1.000 rs12908549 chr15:85322351 C/G cg12863693 chr15:85201151 NMB 0.39 8.05 0.4 1.49e-14 Schizophrenia; LUSC cis rs1891275 0.550 rs4933694 chr10:93499213 C/T cg07889827 chr10:93443413 NA -0.4 -9.15 -0.45 5.91e-18 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg08270630 chr22:50330655 NA -0.45 -6.88 -0.35 2.97e-11 Schizophrenia; LUSC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg00745463 chr17:30367425 LRRC37B -0.69 -8.16 -0.41 6.74e-15 Hip circumference adjusted for BMI; LUSC cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg03146154 chr1:46216737 IPP 0.51 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10911251 0.546 rs3768625 chr1:183078712 G/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.81 0.51 1.51e-23 Colorectal cancer; LUSC cis rs1800562 1 rs1800562 chr6:26093141 C/T cg16482183 chr6:26056742 HIST1H1C 0.89 5.94 0.31 7.01e-9 Hematocrit;Iron status biomarkers (transferrin levels);Diastolic blood pressure;Hemoglobin;Red blood cell count;Cholesterol, total;Hematology traits;Alcohol consumption (transferrin glycosylation);Iron status biomarkers (ferritin levels);LDL cholesterol;Iron status biomarkers;Mean corpuscular hemoglobin;Iron status biomarkers (transferrin saturation);Mean corpuscular volume;Iron status biomarkers (iron levels);Red blood cell traits;Iron status biomarkers (total iron binding capacity);Glycated hemoglobin levels;Hematological parameters;Hepcidin levels;Cardiovascular disease risk factors; LUSC cis rs7528684 0.565 rs10908587 chr1:157643579 G/A cg18268488 chr1:157545234 FCRL4 0.3 5.69 0.3 2.84e-8 Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes; LUSC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg16325326 chr1:53192061 ZYG11B 0.94 17.61 0.69 1.53e-49 Monocyte count; LUSC cis rs10979 1.000 rs9390113 chr6:143896205 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg11764359 chr7:65958608 NA 0.7 10.56 0.5 1.15e-22 Aortic root size; LUSC cis rs2806561 0.769 rs2235547 chr1:23406485 C/G cg19743168 chr1:23544995 NA -0.42 -8.65 -0.43 2.24e-16 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13440781 chr1:168148262 TIPRL 0.68 6.11 0.32 2.84e-9 Cognitive performance; LUSC trans rs877282 0.898 rs11253340 chr10:764786 G/T cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg01879757 chr17:41196368 BRCA1 -0.5 -8.04 -0.4 1.53e-14 Menopause (age at onset); LUSC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg16405210 chr4:1374714 KIAA1530 -0.62 -9.52 -0.46 3.61e-19 Obesity-related traits; LUSC cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg24596788 chr1:163392923 NA -0.44 -7.28 -0.37 2.36e-12 Motion sickness; LUSC cis rs17155006 0.530 rs408867 chr7:107743244 C/T cg05962710 chr7:107745446 LAMB4 -0.33 -5.92 -0.31 8.19e-9 Pneumococcal bacteremia; LUSC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg06022373 chr22:39101656 GTPBP1 0.78 12.16 0.55 2.1e-28 Menopause (age at onset); LUSC cis rs9653442 1.000 rs7580200 chr2:100811903 G/T cg22139774 chr2:100720529 AFF3 0.46 8.3 0.41 2.57e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4363385 0.510 rs12083211 chr1:153032131 A/T cg00922841 chr1:152955080 SPRR1A 0.36 6.08 0.32 3.26e-9 Inflammatory skin disease; LUSC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg16624210 chr5:671434 TPPP 0.47 5.97 0.31 6.06e-9 Obesity-related traits; LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg27535305 chr1:53392650 SCP2 -0.49 -9.7 -0.47 9.36e-20 Monocyte count; LUSC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg13393036 chr8:95962371 TP53INP1 -0.46 -9.57 -0.46 2.49e-19 Type 2 diabetes; LUSC cis rs861020 0.771 rs1962735 chr1:210012102 A/G cg09163369 chr1:210001066 C1orf107 0.48 6.01 0.31 4.86e-9 Orofacial clefts; LUSC cis rs10886558 0.619 rs4752365 chr10:121761989 C/G cg02041677 chr10:121771263 NA -0.34 -5.72 -0.3 2.31e-8 Shingles; LUSC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg20307385 chr11:47447363 PSMC3 0.44 5.72 0.3 2.43e-8 Subjective well-being; LUSC cis rs7589342 0.839 rs11895235 chr2:106432355 C/G cg16077055 chr2:106428750 NCK2 0.38 7.2 0.37 4.02e-12 Addiction; LUSC cis rs8077577 0.895 rs11655797 chr17:18107850 C/T cg16794390 chr17:18148240 FLII 0.41 5.71 0.3 2.52e-8 Obesity-related traits; LUSC cis rs62064224 0.533 rs11657826 chr17:30790386 T/A cg25809561 chr17:30822961 MYO1D 0.56 10.14 0.48 3.17e-21 Schizophrenia; LUSC cis rs7100689 0.646 rs10788586 chr10:82117435 A/G cg00277334 chr10:82204260 NA -0.53 -7.76 -0.39 1.01e-13 Post bronchodilator FEV1; LUSC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg19266014 chr7:2183958 MAD1L1 -0.36 -6.14 -0.32 2.32e-9 Schizophrenia; LUSC cis rs8044868 0.530 rs2550868 chr16:72066072 G/A cg16579770 chr16:72058938 DHODH 0.34 5.75 0.3 2.04e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC trans rs57221529 0.766 rs72706608 chr5:559203 C/T cg08313168 chr12:7315531 NA 0.46 5.98 0.31 5.65e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7177699 0.557 rs12898452 chr15:79112628 C/A cg00540400 chr15:79124168 NA 0.46 7.98 0.4 2.33e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.41 6.27 0.32 1.09e-9 Platelet count; LUSC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg09263875 chr16:632152 PIGQ 0.72 13.43 0.59 3.41e-33 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04210991 chr1:226374609 ACBD3 -0.47 -6.08 -0.32 3.29e-9 Hepatitis; LUSC cis rs2559856 1.000 rs2559858 chr12:102089300 A/G cg12924262 chr12:102091054 CHPT1 0.43 6.07 0.32 3.47e-9 Blood protein levels; LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC trans rs9329221 0.736 rs2001338 chr8:10251217 A/G cg06636001 chr8:8085503 FLJ10661 0.54 7.4 0.38 1.13e-12 Neuroticism; LUSC cis rs6088580 0.524 rs6088552 chr20:33226491 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -7.94 -0.4 3.11e-14 Glomerular filtration rate (creatinine); LUSC cis rs243505 0.965 rs243501 chr7:148438145 C/G cg09806900 chr7:148480153 CUL1 -0.51 -7.28 -0.37 2.39e-12 Inflammatory bowel disease;Crohn's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17954165 chr10:124913710 BUB3 -0.4 -6.01 -0.31 4.75e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg13560548 chr3:10150139 C3orf24 0.5 7.22 0.37 3.44e-12 Alzheimer's disease; LUSC cis rs9309473 0.904 rs79145598 chr2:73821382 T/A cg20560298 chr2:73613845 ALMS1 -0.44 -6.33 -0.33 7.94e-10 Metabolite levels; LUSC cis rs7119167 0.901 rs7937066 chr11:73124928 C/T cg17517138 chr11:73019481 ARHGEF17 0.54 6.07 0.32 3.45e-9 Blood protein levels; LUSC trans rs6600671 0.967 rs4844613 chr1:121173773 T/C cg00646200 chr1:148855367 NA 0.44 6.89 0.35 2.71e-11 Hip geometry; LUSC cis rs826838 1.000 rs826838 chr12:39106731 C/T cg13010199 chr12:38710504 ALG10B -0.65 -11.19 -0.52 6.63e-25 Heart rate; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg01802117 chr1:53393560 SCP2 -0.37 -6.32 -0.33 8.28e-10 Monocyte count; LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs11792861 0.851 rs17552292 chr9:111891954 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.75 0.43 1.09e-16 Menarche (age at onset); LUSC cis rs1572438 0.929 rs9378520 chr6:861685 C/T cg13447295 chr6:887704 NA -0.41 -5.86 -0.31 1.08e-8 Aging; LUSC cis rs17828380 0.920 rs71394509 chr15:63605923 G/A cg05507819 chr15:63340323 TPM1 -0.75 -6.07 -0.32 3.49e-9 Social communication problems; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20860086 chr6:13814875 CCDC90A 0.37 6.0 0.31 5.19e-9 Asthma; LUSC cis rs8099014 0.725 rs12373325 chr18:56087648 C/T cg12907477 chr18:56117327 MIR122 -0.4 -5.87 -0.31 1.03e-8 Platelet count; LUSC trans rs7819412 0.540 rs11777355 chr8:11044689 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.01 -0.36 1.34e-11 Triglycerides; LUSC cis rs1044826 0.642 rs295470 chr3:139213903 A/G cg00490450 chr3:139108681 COPB2 0.46 7.06 0.36 9.57e-12 Obesity-related traits; LUSC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg02569458 chr12:86230093 RASSF9 0.55 9.43 0.46 7.16e-19 Major depressive disorder; LUSC cis rs4474465 1.000 rs12277701 chr11:78140726 A/T cg27205649 chr11:78285834 NARS2 -0.53 -6.18 -0.32 1.85e-9 Alzheimer's disease (survival time); LUSC cis rs7208859 0.623 rs7214570 chr17:29147164 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.68 0.34 9.73e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6736093 0.897 rs4848874 chr2:112681500 A/G cg12686935 chr2:112915763 FBLN7 -0.36 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.18 -0.49 2.18e-21 Menarche (age at onset); LUSC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg24829409 chr8:58192753 C8orf71 -0.62 -7.38 -0.37 1.25e-12 Developmental language disorder (linguistic errors); LUSC cis rs9905704 0.874 rs2643126 chr17:56737765 A/G cg12560992 chr17:57184187 TRIM37 0.55 7.78 0.39 9.24e-14 Testicular germ cell tumor; LUSC cis rs7258465 0.965 rs7253990 chr19:18604085 C/G cg11102782 chr19:18549136 ISYNA1 -0.34 -6.45 -0.33 3.9e-10 Breast cancer; LUSC cis rs5017598 1.000 rs5017598 chr6:169211494 A/G cg05672967 chr6:169256475 NA 0.42 6.21 0.32 1.6e-9 Pediatric bone mineral density (femoral neck);Pediatric bone mineral density (hip); LUSC trans rs2243480 1.000 rs937108 chr7:65428452 G/A cg10756647 chr7:56101905 PSPH 0.85 8.34 0.42 1.93e-15 Diabetic kidney disease; LUSC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.47 0.38 6.98e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg23172400 chr8:95962367 TP53INP1 -0.38 -7.73 -0.39 1.29e-13 Type 2 diabetes; LUSC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -11.72 -0.54 8.37e-27 Systemic lupus erythematosus; LUSC cis rs7103648 1.000 rs10838705 chr11:47424931 G/A cg20307385 chr11:47447363 PSMC3 0.99 19.37 0.73 1.45e-56 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs9790314 0.586 rs73021449 chr3:161128941 G/A cg03342759 chr3:160939853 NMD3 -0.44 -6.79 -0.35 5.01e-11 Morning vs. evening chronotype; LUSC cis rs1322512 0.713 rs1727042 chr6:152939017 A/G cg27316956 chr6:152958899 SYNE1 0.34 5.71 0.3 2.48e-8 Tonometry; LUSC cis rs80282103 0.764 rs12247779 chr10:1107957 T/G cg08668510 chr10:1095578 IDI1 0.73 6.58 0.34 1.8e-10 Glomerular filtration rate (creatinine); LUSC cis rs2370759 1.000 rs79442609 chr10:32608749 C/T cg01819863 chr10:32635814 EPC1 1.06 12.81 0.57 8.04e-31 Sexual dysfunction (female); LUSC cis rs12760731 0.641 rs12727289 chr1:178327027 T/C cg00404053 chr1:178313656 RASAL2 0.54 6.19 0.32 1.73e-9 Obesity-related traits; LUSC cis rs3008870 1.000 rs4655663 chr1:67430103 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.46 0.65 4.65e-41 Lymphocyte percentage of white cells; LUSC cis rs9814567 1.000 rs2887797 chr3:134202506 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -13.7 -0.6 3.35e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg22907277 chr7:1156413 C7orf50 0.72 7.68 0.39 1.75e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs79349575 0.783 rs12453394 chr17:46994970 G/A cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC cis rs10843647 1.000 rs4931282 chr12:30329500 A/G cg12718339 chr12:29936407 TMTC1 -0.34 -5.77 -0.3 1.77e-8 Glucose homeostasis traits; LUSC cis rs10740039 0.810 rs10159646 chr10:62380124 A/G cg18175470 chr10:62150864 ANK3 -0.48 -7.25 -0.37 2.88e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg17252645 chr8:143867129 LY6D 0.38 6.68 0.34 1.02e-10 Urinary tract infection frequency; LUSC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg11663144 chr21:46675770 NA -0.43 -7.61 -0.38 2.83e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11098499 0.691 rs28396837 chr4:120271541 G/A cg24375607 chr4:120327624 NA 0.67 10.54 0.5 1.33e-22 Corneal astigmatism; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg12592908 chr6:36954170 MTCH1 0.38 5.99 0.31 5.53e-9 Schizophrenia (age at onset); LUSC cis rs7119 0.717 rs12910975 chr15:77817487 C/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg18225595 chr11:63971243 STIP1 -0.47 -7.63 -0.39 2.4e-13 Platelet count; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg02353165 chr6:42928485 GNMT 0.67 11.39 0.53 1.3e-25 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.55 0.42 4.64e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7264396 0.887 rs750487 chr20:34066645 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.42 -0.33 4.74e-10 Total cholesterol levels; LUSC cis rs6084875 0.840 rs2422934 chr20:4720146 G/A cg07258627 chr20:4721683 PRNT -0.34 -6.2 -0.32 1.69e-9 Systemic lupus erythematosus; LUSC trans rs9393777 0.720 rs56874662 chr6:26985607 C/A cg06606381 chr12:133084897 FBRSL1 -0.61 -6.44 -0.33 4.28e-10 Intelligence (multi-trait analysis); LUSC trans rs564343 0.583 rs2430978 chr11:65816656 G/C cg26701943 chr11:108369231 KDELC2 -0.44 -6.0 -0.31 5.28e-9 Obesity (early onset extreme); LUSC cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg17420585 chr12:42539391 GXYLT1 -0.37 -7.27 -0.37 2.57e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12801636 0.846 rs1078457 chr11:65380124 C/T cg21033440 chr11:65409861 SIPA1 -0.58 -7.63 -0.39 2.42e-13 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs1728785 1.000 rs11648314 chr16:68596775 A/G cg02972257 chr16:68554789 NA -0.52 -6.39 -0.33 5.65e-10 Ulcerative colitis; LUSC trans rs61931739 0.500 rs7965421 chr12:34523624 G/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.78 -9.55 -0.46 2.82e-19 Schizophrenia; LUSC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.71 0.34 8.26e-11 Lung cancer; LUSC trans rs853679 0.517 rs9380065 chr6:28144751 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.16e-9 Depression; LUSC cis rs8014204 0.935 rs4903267 chr14:75360419 G/T cg08847533 chr14:75593920 NEK9 -0.39 -5.67 -0.3 3.06e-8 Caffeine consumption; LUSC cis rs936229 0.651 rs12908814 chr15:75132490 C/G cg10253484 chr15:75165896 SCAMP2 -0.43 -6.01 -0.31 4.93e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs11098499 1.000 rs11098500 chr4:120219239 T/A cg24375607 chr4:120327624 NA 0.73 10.8 0.51 1.58e-23 Corneal astigmatism; LUSC cis rs3540 0.533 rs2256097 chr15:90971331 A/T cg03599575 chr15:90893182 GABARAPL3 0.33 5.87 0.31 1.03e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.29e-12 Tonsillectomy; LUSC cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.3 -0.45 1.85e-18 Schizophrenia; LUSC cis rs965469 1.000 rs6051753 chr20:3315513 G/A cg25506879 chr20:3388711 C20orf194 -0.52 -5.7 -0.3 2.68e-8 IFN-related cytopenia; LUSC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg19920283 chr7:105172520 RINT1 0.61 6.62 0.34 1.42e-10 Bipolar disorder (body mass index interaction); LUSC cis rs6845621 0.727 rs4464564 chr4:18907036 A/G cg12196642 chr4:18937545 NA -0.33 -6.27 -0.32 1.1e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg17420585 chr12:42539391 GXYLT1 -0.37 -7.25 -0.37 2.87e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs79839061 0.610 rs62297087 chr4:913289 T/A cg23992470 chr4:843637 GAK 0.56 6.15 0.32 2.18e-9 Intelligence (multi-trait analysis); LUSC cis rs116139393 0.536 rs13247186 chr7:6769155 A/G cg09896999 chr7:6746977 ZNF12 -0.57 -8.5 -0.42 6.54e-16 Alzheimer's disease (APOE e4 interaction); LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.97 -0.4 2.62e-14 Lymphocyte counts; LUSC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg27170947 chr2:26402098 FAM59B -0.63 -9.22 -0.45 3.41e-18 Gut microbiome composition (summer); LUSC cis rs10865397 0.506 rs6546807 chr2:73386212 C/T cg24220031 chr2:73402428 NA -0.26 -6.06 -0.31 3.61e-9 Intelligence (multi-trait analysis); LUSC cis rs7216064 1.000 rs4569324 chr17:65872750 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg17443473 chr1:3703550 LRRC47 0.34 5.89 0.31 9.5e-9 Red cell distribution width; LUSC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg13319975 chr6:146136371 FBXO30 0.51 7.76 0.39 1.06e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303280 0.806 rs10445308 chr17:37938047 C/T cg19468946 chr17:37922297 IKZF3 -0.46 -7.32 -0.37 1.88e-12 Self-reported allergy; LUSC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg22862634 chr11:62369728 EML3;MTA2 0.49 7.16 0.36 5.31e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6500395 0.775 rs8050844 chr16:48665696 A/G cg04672837 chr16:48644449 N4BP1 0.47 7.02 0.36 1.22e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12421382 0.659 rs2028337 chr11:109380887 G/C cg27471124 chr11:109292789 C11orf87 0.41 7.09 0.36 8.05e-12 Schizophrenia; LUSC cis rs9925964 0.933 rs8050894 chr16:31104509 C/G cg02466173 chr16:30829666 NA 0.34 6.04 0.31 4.15e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.92 0.35 2.31e-11 Mood instability; LUSC cis rs9814567 1.000 rs1534026 chr3:134284767 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.0 -0.61 2.26e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs61931739 0.500 rs10844848 chr12:34409705 A/C cg26384229 chr12:38710491 ALG10B 0.91 15.79 0.65 2.43e-42 Morning vs. evening chronotype; LUSC cis rs12579753 0.917 rs71466033 chr12:82242187 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs2294693 0.891 rs4714421 chr6:40992837 C/T cg14769373 chr6:40998127 UNC5CL -0.48 -7.0 -0.36 1.45e-11 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg06634786 chr22:41940651 POLR3H 0.49 6.12 0.32 2.56e-9 Vitiligo; LUSC cis rs6066835 1.000 rs4431002 chr20:47316585 C/T cg18078177 chr20:47281410 PREX1 0.72 6.13 0.32 2.51e-9 Multiple myeloma; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg02796970 chr10:39023768 NA -0.49 -7.9 -0.4 4.17e-14 Menopause (age at onset); LUSC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs300703 0.542 rs300696 chr2:183330 G/A cg21211680 chr2:198530 NA -0.6 -7.34 -0.37 1.68e-12 Blood protein levels; LUSC trans rs61931739 0.534 rs4086956 chr12:34105047 A/T cg26384229 chr12:38710491 ALG10B 0.7 10.74 0.51 2.52e-23 Morning vs. evening chronotype; LUSC trans rs12579753 0.917 rs7972839 chr12:82178920 C/T cg07923666 chr12:49932857 KCNH3 -0.48 -6.02 -0.31 4.48e-9 Resting heart rate; LUSC cis rs1595825 0.891 rs78198610 chr2:198522769 T/C cg19156104 chr2:198669113 PLCL1 -0.45 -5.69 -0.3 2.74e-8 Ulcerative colitis; LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg05025164 chr4:1340916 KIAA1530 0.53 8.17 0.41 6.63e-15 Obesity-related traits; LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg05457628 chr5:178986728 RUFY1 -0.64 -11.8 -0.54 4.18e-27 Lung cancer; LUSC cis rs7085104 0.513 rs619824 chr10:104581288 G/T cg04362960 chr10:104952993 NT5C2 0.6 9.38 0.46 1.05e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg01448562 chr3:133502909 NA -0.36 -5.67 -0.3 3.04e-8 Iron status biomarkers (transferrin levels); LUSC trans rs61931739 0.534 rs11052959 chr12:33997095 T/C cg26384229 chr12:38710491 ALG10B 0.74 11.5 0.53 5.04e-26 Morning vs. evening chronotype; LUSC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg03806693 chr22:41940476 POLR3H 0.99 14.14 0.61 6.88e-36 Vitiligo; LUSC cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.63 0.85 1.69e-95 Chronic sinus infection; LUSC trans rs61931739 0.571 rs4001689 chr12:34243271 C/T cg26384229 chr12:38710491 ALG10B 0.71 11.61 0.54 2.13e-26 Morning vs. evening chronotype; LUSC cis rs7258465 1.000 rs10164319 chr19:18569833 G/A cg11102782 chr19:18549136 ISYNA1 -0.34 -6.38 -0.33 5.88e-10 Breast cancer; LUSC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg05861140 chr6:150128134 PCMT1 -0.39 -5.83 -0.3 1.3e-8 Lung cancer; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg11060661 chr22:24314208 DDT;DDTL 0.45 7.59 0.38 3.2e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg26818010 chr10:134567672 INPP5A -0.87 -11.48 -0.53 6.2e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs1372520 0.684 rs10008964 chr4:90744721 G/A cg15133208 chr4:90757351 SNCA -0.53 -8.1 -0.41 1.04e-14 Neuroticism; LUSC cis rs7824557 0.547 rs2409745 chr8:11076635 G/T cg21775007 chr8:11205619 TDH 0.57 8.39 0.42 1.43e-15 Retinal vascular caliber; LUSC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg11752832 chr7:134001865 SLC35B4 0.55 8.66 0.43 2.09e-16 Mean platelet volume; LUSC cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg13535736 chr9:111863775 C9orf5 -0.39 -6.14 -0.32 2.3e-9 Menarche (age at onset); LUSC cis rs801193 0.901 rs4273746 chr7:66301111 C/T cg00343986 chr7:65444356 GUSB -0.41 -6.1 -0.32 3.01e-9 Aortic root size; LUSC cis rs13315871 1.000 rs13060489 chr3:58339287 G/A cg20936604 chr3:58311152 NA -0.71 -6.95 -0.36 1.96e-11 Cholesterol, total; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15785704 chr17:30669010 C17orf75 0.49 6.58 0.34 1.78e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11648796 0.757 rs6600231 chr16:766485 A/G cg27144592 chr16:783916 NARFL -0.63 -9.77 -0.47 5.55e-20 Height; LUSC cis rs4909189 1.000 rs62493651 chr7:158135592 T/C cg24154853 chr7:158122151 PTPRN2 0.35 5.77 0.3 1.82e-8 Response to amphetamines; LUSC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg04944784 chr2:26401820 FAM59B 0.71 10.03 0.48 7.07e-21 Gut microbiome composition (summer); LUSC cis rs12950390 0.853 rs11655336 chr17:45858836 A/G cg06532163 chr17:45867833 NA -0.33 -6.21 -0.32 1.6e-9 IgG glycosylation; LUSC cis rs877282 0.797 rs11253329 chr10:753200 A/T cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs72634258 0.945 rs161800 chr1:8042402 A/T cg00042356 chr1:8021962 PARK7 0.64 8.37 0.42 1.55e-15 Inflammatory bowel disease; LUSC cis rs9914988 0.778 rs35398767 chr17:27122960 A/T cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7503807 1.000 rs12939613 chr17:78588202 A/G cg09596252 chr17:78655493 RPTOR 0.41 7.09 0.36 8.26e-12 Obesity; LUSC cis rs977987 0.806 rs7185640 chr16:75394399 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.85 -0.35 3.47e-11 Dupuytren's disease; LUSC cis rs735396 1.000 rs1169309 chr12:121439192 G/T cg02403541 chr12:121454288 C12orf43 0.59 8.45 0.42 8.98e-16 N-glycan levels; LUSC cis rs4566357 0.615 rs12328876 chr2:227918899 G/T cg11843606 chr2:227700838 RHBDD1 -0.54 -8.23 -0.41 4.35e-15 Coronary artery disease; LUSC trans rs853679 0.517 rs35227624 chr6:28132726 A/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC trans rs7746199 0.736 rs13202291 chr6:27698857 A/G cg01620082 chr3:125678407 NA -0.78 -7.29 -0.37 2.28e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg13685833 chr1:53393034 SCP2 -0.38 -5.8 -0.3 1.55e-8 Monocyte count; LUSC cis rs698813 0.674 rs11680456 chr2:44497544 C/G cg00619915 chr2:44497795 NA -0.51 -7.03 -0.36 1.14e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg00191853 chr8:101177733 SPAG1 0.5 8.64 0.43 2.3e-16 Atrioventricular conduction; LUSC cis rs7264396 0.563 rs3827029 chr20:34332784 G/T cg04508476 chr20:34239394 CPNE1;RBM12 0.59 8.14 0.41 7.69e-15 Total cholesterol levels; LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.82 0.47 3.65e-20 Bipolar disorder; LUSC cis rs617219 0.853 rs3733892 chr5:78532088 A/C cg24856658 chr5:78533917 JMY -0.3 -5.83 -0.3 1.3e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs920590 0.643 rs7012694 chr8:19662732 C/T cg03894339 chr8:19674705 INTS10 0.41 5.87 0.31 1.05e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs12950390 0.853 rs11079792 chr17:45863311 T/C cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.48e-10 IgG glycosylation; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg04234412 chr22:24373322 LOC391322 -0.86 -14.05 -0.61 1.5e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11039798 0.588 rs10838970 chr11:48606267 G/T cg03929089 chr4:120376271 NA 0.59 6.44 0.33 4.04e-10 Axial length; LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg02951883 chr7:2050386 MAD1L1 -0.65 -12.72 -0.57 1.7e-30 Bipolar disorder and schizophrenia; LUSC cis rs4964805 1.000 rs4964805 chr12:104192824 C/G cg02344784 chr12:104178138 NT5DC3 0.45 7.21 0.37 3.74e-12 Attention deficit hyperactivity disorder; LUSC cis rs6845621 0.727 rs13129810 chr4:18914830 T/G cg12196642 chr4:18937545 NA -0.34 -6.29 -0.33 9.99e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs4555082 0.874 rs11625098 chr14:105756891 A/G cg06808227 chr14:105710500 BRF1 -0.6 -8.39 -0.42 1.37e-15 Mean platelet volume;Platelet distribution width; LUSC trans rs1325195 0.920 rs1078872 chr1:179223726 C/T cg11624085 chr17:8464688 MYH10 -0.39 -6.34 -0.33 7.46e-10 IgE grass sensitization; LUSC cis rs2652834 1.000 rs2134265 chr15:63398196 G/A cg05507819 chr15:63340323 TPM1 0.69 8.32 0.41 2.22e-15 HDL cholesterol; LUSC cis rs4891159 0.548 rs689902 chr18:74119969 C/T cg24786174 chr18:74118243 ZNF516 -0.97 -20.99 -0.75 5.64e-63 Longevity; LUSC cis rs117352156 0.943 rs4367855 chr10:29223312 C/T cg06394621 chr10:29236369 NA -0.42 -5.69 -0.3 2.85e-8 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11890956 chr21:40555474 PSMG1 1.03 21.06 0.76 2.9e-63 Cognitive function; LUSC cis rs9325144 0.752 rs12300353 chr12:39154492 G/C cg13010199 chr12:38710504 ALG10B -0.5 -7.52 -0.38 5.12e-13 Morning vs. evening chronotype; LUSC cis rs372883 0.507 rs8132992 chr21:30750561 T/C cg08807101 chr21:30365312 RNF160 0.63 10.11 0.48 3.91e-21 Pancreatic cancer; LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 15.17 0.64 6.55e-40 Platelet count; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg10488141 chr10:104264014 SUFU 0.38 5.97 0.31 6.22e-9 Asthma; LUSC cis rs9473147 0.516 rs7767350 chr6:47485126 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.79 0.3 1.66e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg00750074 chr16:89608354 SPG7 -0.53 -9.55 -0.46 2.96e-19 Multiple myeloma (IgH translocation); LUSC cis rs4919694 0.572 rs12262258 chr10:104900272 G/A cg05855489 chr10:104503620 C10orf26 0.54 6.39 0.33 5.67e-10 Arsenic metabolism; LUSC cis rs4144743 0.941 rs7222617 chr17:45324080 G/T cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg08088566 chr11:430123 ANO9 0.71 7.64 0.39 2.25e-13 Body mass index; LUSC cis rs1712517 0.771 rs11191676 chr10:105155066 C/A cg05636881 chr10:105038444 INA 0.42 7.01 0.36 1.28e-11 Migraine; LUSC cis rs72781680 1.000 rs72781632 chr2:24198342 A/C cg08917208 chr2:24149416 ATAD2B 1.0 10.49 0.5 1.94e-22 Lymphocyte counts; LUSC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg21361702 chr7:150065534 REPIN1 0.49 6.53 0.34 2.42e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg27165867 chr14:105738592 BRF1 -0.52 -7.66 -0.39 2.01e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs965469 1.000 rs2236118 chr20:3302058 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -5.79 -0.3 1.65e-8 IFN-related cytopenia; LUSC cis rs7539542 0.556 rs1539357 chr1:202878454 T/A cg19681188 chr1:202830198 LOC148709 0.39 5.8 0.3 1.54e-8 Mean platelet volume; LUSC cis rs9902453 0.730 rs4583306 chr17:28538715 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.45 -6.59 -0.34 1.76e-10 Coffee consumption (cups per day); LUSC cis rs11190604 1.000 rs10786598 chr10:102291579 G/A cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2806561 0.765 rs652783 chr1:23514313 G/T cg19743168 chr1:23544995 NA 0.4 7.96 0.4 2.78e-14 Height; LUSC cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.08 21.02 0.75 4.3e-63 Cognitive ability; LUSC cis rs7959452 0.640 rs4761233 chr12:69722880 T/C cg22834771 chr12:69754056 YEATS4 -0.45 -6.5 -0.33 3.01e-10 Blood protein levels; LUSC cis rs7633770 0.786 rs1520488 chr3:46677459 C/T cg11219411 chr3:46661640 NA 0.36 7.56 0.38 3.82e-13 Coronary artery disease; LUSC trans rs7829975 0.681 rs2271342 chr8:8643938 C/T cg27411982 chr8:10470053 RP1L1 0.43 6.83 0.35 3.99e-11 Mood instability; LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg25072359 chr17:41440525 NA 0.66 9.45 0.46 6.13e-19 Menopause (age at onset); LUSC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg03929089 chr4:120376271 NA -1.04 -20.09 -0.74 2.02e-59 Height; LUSC trans rs9409565 0.793 rs2486632 chr9:97196979 A/G cg05679027 chr9:99775184 HIATL2 -0.49 -7.02 -0.36 1.21e-11 Colorectal cancer (alcohol consumption interaction); LUSC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg03060546 chr3:49711283 APEH 0.71 11.95 0.55 1.23e-27 Resting heart rate; LUSC cis rs10911232 0.507 rs2151669 chr1:183055398 T/G ch.1.3577855R chr1:183094577 LAMC1 0.71 11.03 0.52 2.56e-24 Hypertriglyceridemia; LUSC cis rs12618769 0.597 rs17032120 chr2:99082938 A/G cg10123293 chr2:99228465 UNC50 -0.42 -7.17 -0.37 4.76e-12 Bipolar disorder; LUSC cis rs9807989 0.773 rs5010059 chr2:102968826 C/G cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs6681460 0.674 rs4134135 chr1:67012728 A/G cg02459107 chr1:67143332 SGIP1 0.38 6.11 0.32 2.81e-9 Presence of antiphospholipid antibodies; LUSC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg18252515 chr7:66147081 NA -1.22 -13.44 -0.59 3.3e-33 Diabetic kidney disease; LUSC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg17143192 chr8:8559678 CLDN23 0.59 8.58 0.43 3.58e-16 Obesity-related traits; LUSC cis rs2677744 0.626 rs867468 chr15:91498127 G/A cg23684204 chr15:91497937 RCCD1 0.57 7.92 0.4 3.57e-14 Attention deficit hyperactivity disorder; LUSC cis rs4853012 0.887 rs7570950 chr2:74338942 T/C cg19729930 chr2:74357872 NA 0.85 14.66 0.63 6.27e-38 Gestational age at birth (maternal effect); LUSC cis rs6489882 0.703 rs6489865 chr12:113360302 A/G cg20102336 chr12:113376681 OAS3 -0.41 -5.75 -0.3 2.02e-8 Chronic lymphocytic leukemia; LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.5 -6.8 -0.35 4.96e-11 Renal function-related traits (BUN); LUSC cis rs7267979 1.000 rs4815407 chr20:25341478 G/C cg08601574 chr20:25228251 PYGB -0.43 -6.67 -0.34 1.04e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6964587 0.620 rs7808587 chr7:91620096 G/A cg17063962 chr7:91808500 NA 0.57 9.54 0.46 3.09e-19 Breast cancer; LUSC trans rs2243480 0.522 rs1638736 chr7:66092308 A/T cg07424592 chr7:64974309 NA 0.91 6.01 0.31 4.97e-9 Diabetic kidney disease; LUSC cis rs9921338 0.961 rs6498185 chr16:11444726 C/T cg00044050 chr16:11439710 C16orf75 -0.5 -6.66 -0.34 1.11e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs644799 0.625 rs1255175 chr11:95471186 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.31 0.33 8.94e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9314323 0.692 rs6557914 chr8:26208744 G/C cg11498726 chr8:26250323 BNIP3L -0.43 -6.12 -0.32 2.63e-9 Red cell distribution width; LUSC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg03517284 chr6:25882590 NA -0.55 -9.03 -0.44 1.4e-17 Intelligence (multi-trait analysis); LUSC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg24060327 chr5:131705240 SLC22A5 -0.36 -5.69 -0.3 2.85e-8 Breast cancer;Mosquito bite size; LUSC trans rs72674100 1.000 rs7673826 chr4:97978191 A/G cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg00484396 chr16:3507460 NAT15 0.45 7.38 0.37 1.29e-12 Body mass index (adult); LUSC cis rs34638657 0.673 rs62045961 chr16:82199723 A/G cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.55e-10 Lung adenocarcinoma; LUSC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg21644426 chr2:191273491 MFSD6 0.61 9.73 0.47 7.24e-20 Pulse pressure; LUSC cis rs483180 0.511 rs496195 chr1:120207182 A/G cg19096424 chr1:120255104 PHGDH -0.48 -6.68 -0.34 1.02e-10 Macular telangiectasia type 2; LUSC cis rs3008870 1.000 rs35365746 chr1:67438900 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.11 -0.64 1.09e-39 Lymphocyte percentage of white cells; LUSC cis rs2299587 0.585 rs2073569 chr8:17782158 T/G cg01800426 chr8:17659068 MTUS1 -0.49 -6.53 -0.34 2.51e-10 Economic and political preferences; LUSC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg07157834 chr1:205819609 PM20D1 0.44 5.77 0.3 1.85e-8 Parkinson's disease; LUSC cis rs6430585 0.702 rs73958637 chr2:136546927 C/T cg07169764 chr2:136633963 MCM6 1.17 17.34 0.69 1.75e-48 Corneal structure; LUSC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg27121462 chr16:89883253 FANCA 0.44 6.23 0.32 1.44e-9 Vitiligo; LUSC cis rs4629180 0.586 rs10172555 chr2:102126837 C/T cg01388757 chr2:102091195 RFX8 -0.36 -6.38 -0.33 5.88e-10 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7202877 0.610 rs8053632 chr16:75364940 C/T cg03315344 chr16:75512273 CHST6 0.42 6.21 0.32 1.57e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg14552801 chr7:65878734 NA 0.36 5.69 0.3 2.71e-8 Aortic root size; LUSC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg10523679 chr1:76189770 ACADM 0.9 13.87 0.6 7.3e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9300255 0.568 rs1047158 chr12:123644056 C/A cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.12 -0.32 2.63e-9 Neutrophil percentage of white cells; LUSC cis rs372883 0.648 rs11088117 chr21:30737816 G/C cg08807101 chr21:30365312 RNF160 0.68 11.0 0.52 3.22e-24 Pancreatic cancer; LUSC cis rs9462027 0.540 rs9469867 chr6:34742449 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.75 -0.3 1.97e-8 Systemic lupus erythematosus; LUSC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg04414720 chr1:150670196 GOLPH3L 0.53 8.11 0.41 9.43e-15 Melanoma; LUSC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg03929089 chr4:120376271 NA -0.94 -16.46 -0.67 5.66e-45 Height; LUSC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg25554036 chr4:6271136 WFS1 0.61 12.55 0.57 7.31e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9814567 0.806 rs6806810 chr3:134323522 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.31 -0.56 5.64e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4629710 0.592 rs3777476 chr6:131533821 A/C cg12700074 chr6:131571435 AKAP7 -0.37 -6.25 -0.32 1.25e-9 Multiple myeloma (IgH translocation); LUSC cis rs3771570 1.000 rs16843590 chr2:242298228 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.76 0.35 6.25e-11 Prostate cancer; LUSC cis rs950776 0.518 rs12916483 chr15:78832397 G/A cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg25838465 chr1:92012736 NA -0.74 -15.16 -0.64 7.08e-40 Breast cancer; LUSC cis rs3008870 1.000 rs2815348 chr1:67472165 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.02 0.63 2.62e-39 Lymphocyte percentage of white cells; LUSC trans rs61931739 0.658 rs10772149 chr12:34285498 A/G cg26384229 chr12:38710491 ALG10B 0.53 8.42 0.42 1.11e-15 Morning vs. evening chronotype; LUSC cis rs3008870 1.000 rs975451 chr1:67480060 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.31 0.64 1.87e-40 Lymphocyte percentage of white cells; LUSC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg11366901 chr6:160182831 ACAT2 0.96 12.93 0.58 2.65e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.52 9.26 0.45 2.51e-18 Bipolar disorder; LUSC cis rs354225 0.584 rs6706263 chr2:54815240 C/T cg26097391 chr2:54893211 SPTBN1 0.43 6.46 0.33 3.68e-10 Schizophrenia; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg05665937 chr4:1216051 CTBP1 -0.37 -5.89 -0.31 9.44e-9 Obesity-related traits; LUSC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -11.4 -0.53 1.23e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg26924012 chr15:45694286 SPATA5L1 -1.11 -20.0 -0.74 4.73e-59 Homoarginine levels; LUSC cis rs9467711 0.606 rs1977 chr6:26377546 A/G cg09904177 chr6:26538194 HMGN4 -0.72 -6.82 -0.35 4.39e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg22823121 chr1:150693482 HORMAD1 -0.44 -6.61 -0.34 1.48e-10 Melanoma; LUSC cis rs3857536 0.707 rs9345793 chr6:66929807 G/C cg07460842 chr6:66804631 NA -0.47 -6.42 -0.33 4.68e-10 Blood trace element (Cu levels); LUSC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg06112835 chr11:68658793 MRPL21 0.51 7.81 0.39 7.24e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg08847533 chr14:75593920 NEK9 -0.79 -13.38 -0.59 5.24e-33 Height; LUSC cis rs11098499 0.754 rs12507565 chr4:120251121 G/A cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC trans rs12310956 0.532 rs10844720 chr12:33987859 G/T cg13010199 chr12:38710504 ALG10B 0.52 7.72 0.39 1.34e-13 Morning vs. evening chronotype; LUSC cis rs6964587 0.967 rs10246036 chr7:91558523 G/A cg01689657 chr7:91764605 CYP51A1 -0.33 -5.8 -0.3 1.51e-8 Breast cancer; LUSC cis rs9467773 1.000 rs6926629 chr6:26499903 T/C cg05738196 chr6:26577821 NA 0.79 14.86 0.63 1.05e-38 Intelligence (multi-trait analysis); LUSC cis rs11935103 0.569 rs6816112 chr4:187285215 G/A cg24610901 chr4:187293114 NA -0.42 -5.72 -0.3 2.38e-8 Response to citalopram treatment; LUSC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg14552801 chr7:65878734 NA 0.39 6.08 0.32 3.34e-9 Aortic root size; LUSC cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg05347473 chr6:146136440 FBXO30 0.47 8.13 0.41 8.37e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs9399135 0.935 rs9376086 chr6:135371329 T/C cg22676075 chr6:135203613 NA 0.46 7.13 0.36 6.1e-12 Red blood cell count; LUSC trans rs7824557 0.564 rs34964435 chr8:11230206 G/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.84 -0.39 5.94e-14 Retinal vascular caliber; LUSC cis rs3858526 0.834 rs7113548 chr11:5989293 G/A cg05234568 chr11:5960015 NA -0.62 -8.77 -0.43 9.03e-17 DNA methylation (variation); LUSC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg03806693 chr22:41940476 POLR3H -1.02 -13.69 -0.6 3.75e-34 Vitiligo; LUSC cis rs11785400 0.793 rs13248524 chr8:143739343 T/C cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs3806843 1.000 rs2240695 chr5:140168151 G/T cg19875535 chr5:140030758 IK 0.51 8.37 0.42 1.55e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs2625529 0.824 rs4445848 chr15:72354598 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.52 -0.38 5.01e-13 Red blood cell count; LUSC cis rs796364 0.806 rs112486506 chr2:201073947 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.97 -0.4 2.56e-14 Schizophrenia; LUSC cis rs11758351 1.000 rs2143347 chr6:26198494 C/T cg23601095 chr6:26197514 HIST1H3D 0.74 7.53 0.38 4.91e-13 Gout;Renal underexcretion gout; LUSC cis rs807669 0.525 rs2282684 chr22:19184244 C/T cg02655711 chr22:19163373 SLC25A1 0.5 9.04 0.44 1.32e-17 Metabolite levels; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24542126 chr1:27022232 ARID1A 0.37 6.03 0.31 4.46e-9 Asthma; LUSC trans rs4689388 0.890 rs4481292 chr4:6298375 C/T cg17567195 chr5:167378696 ODZ2 -0.4 -6.2 -0.32 1.68e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11098499 0.955 rs11931312 chr4:120159023 T/C cg09307838 chr4:120376055 NA 0.71 10.24 0.49 1.41e-21 Corneal astigmatism; LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg19592336 chr6:28129416 ZNF389 0.48 6.47 0.33 3.51e-10 Parkinson's disease; LUSC cis rs9325144 0.560 rs7971313 chr12:38653413 A/G cg13010199 chr12:38710504 ALG10B -0.53 -8.1 -0.41 1.03e-14 Morning vs. evening chronotype; LUSC cis rs9549260 0.753 rs9549254 chr13:41234763 G/A cg21288729 chr13:41239152 FOXO1 0.56 6.29 0.33 9.83e-10 Red blood cell count; LUSC cis rs6933660 0.512 rs9383905 chr6:151804296 C/T cg03627880 chr6:151815985 C6orf97 -0.57 -6.18 -0.32 1.91e-9 Menarche (age at onset); LUSC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -7.41 -0.38 1.03e-12 Developmental language disorder (linguistic errors); LUSC cis rs7727544 0.716 rs6863213 chr5:131575932 C/T cg12564285 chr5:131593104 PDLIM4 0.34 6.17 0.32 1.95e-9 Blood metabolite levels; LUSC cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg11266682 chr4:10021025 SLC2A9 0.55 10.12 0.48 3.47e-21 Bone mineral density; LUSC trans rs12579753 0.917 rs11115032 chr12:82205073 T/C cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs2180341 0.597 rs3798859 chr6:127663116 C/T cg27446573 chr6:127587934 RNF146 0.61 9.81 0.47 3.91e-20 Breast cancer; LUSC cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -7.26 -0.37 2.71e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg07636037 chr3:49044803 WDR6 1.05 19.08 0.72 1.98e-55 Parkinson's disease; LUSC cis rs7463659 1.000 rs7463659 chr8:135432140 T/C cg17885191 chr8:135476712 NA -0.41 -5.83 -0.3 1.32e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg11645453 chr3:52864694 ITIH4 -0.34 -7.62 -0.38 2.65e-13 Bipolar disorder; LUSC trans rs4843747 0.671 rs13334603 chr16:88116016 T/C cg26811252 chr16:29126840 RRN3P2 0.61 9.74 0.47 6.53e-20 Menopause (age at onset); LUSC cis rs73198271 0.960 rs12155530 chr8:8610964 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -5.76 -0.3 1.92e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg22963979 chr7:1858916 MAD1L1 -0.44 -6.52 -0.34 2.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs1790761 0.505 rs2370141 chr11:67348529 A/G cg24690094 chr11:67383802 NA -0.3 -5.75 -0.3 1.98e-8 Mean corpuscular volume; LUSC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.92 0.44 3.11e-17 Hip circumference adjusted for BMI; LUSC cis rs6062509 0.630 rs6011058 chr20:62356627 C/T cg21849932 chr20:62369462 LIME1 -0.4 -5.82 -0.3 1.41e-8 Prostate cancer; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.02 -0.4 1.83e-14 Lymphocyte counts; LUSC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.47 6.85 0.35 3.62e-11 Alzheimer's disease (late onset); LUSC cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg00071950 chr4:10020882 SLC2A9 0.58 9.58 0.46 2.33e-19 Bone mineral density; LUSC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg06634786 chr22:41940651 POLR3H -0.54 -6.33 -0.33 7.84e-10 Vitiligo; LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.3 -0.41 2.6e-15 Gut microbiome composition (summer); LUSC cis rs6089584 1.000 rs3787424 chr20:60559219 G/A cg06108461 chr20:60628389 TAF4 -0.93 -15.51 -0.65 3.03e-41 Body mass index; LUSC cis rs4595586 0.545 rs7310463 chr12:39368927 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs11190604 1.000 rs12358187 chr10:102284449 C/G cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.26e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg11366901 chr6:160182831 ACAT2 0.9 12.21 0.56 1.35e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg01097406 chr16:89675127 NA -0.37 -7.61 -0.38 2.9e-13 Vitiligo; LUSC cis rs9888739 1.000 rs13338069 chr16:31299474 A/G cg15817542 chr16:31343056 ITGAM -0.51 -6.02 -0.31 4.61e-9 Systemic lupus erythematosus; LUSC cis rs9329221 0.935 rs3750311 chr8:10283602 C/A cg27411982 chr8:10470053 RP1L1 -0.45 -6.95 -0.36 1.93e-11 Neuroticism; LUSC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg17077180 chr1:38461687 NA -0.45 -6.11 -0.32 2.8e-9 Coronary artery disease; LUSC cis rs3845702 0.736 rs6722147 chr2:180829704 G/A cg01881094 chr2:180872142 CWC22 -1.06 -12.75 -0.57 1.28e-30 Schizophrenia; LUSC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg02569458 chr12:86230093 RASSF9 0.6 9.9 0.48 1.94e-20 Major depressive disorder; LUSC cis rs71403859 0.667 rs35538253 chr16:71677975 C/T cg08717414 chr16:71523259 ZNF19 -0.67 -7.56 -0.38 4.01e-13 Post bronchodilator FEV1; LUSC cis rs1873147 0.861 rs2899687 chr15:63325548 C/T cg12160578 chr15:63334699 TPM1 -0.46 -6.37 -0.33 6.28e-10 Orofacial clefts; LUSC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg22823121 chr1:150693482 HORMAD1 -0.45 -6.66 -0.34 1.1e-10 Lymphocyte counts; LUSC cis rs2063714 0.967 rs913971 chr6:157197802 C/T cg23222435 chr6:157204239 ARID1B -0.54 -8.86 -0.44 4.99e-17 Sitting height ratio; LUSC cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg18132916 chr6:79620363 NA -0.38 -5.77 -0.3 1.83e-8 Intelligence (multi-trait analysis); LUSC cis rs7572644 0.713 rs7560060 chr2:28057524 T/C cg27432699 chr2:27873401 GPN1 0.52 6.62 0.34 1.45e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1348850 0.526 rs935426 chr2:178369433 T/C cg22681709 chr2:178499509 PDE11A -0.47 -6.88 -0.35 2.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1577917 0.958 rs12192033 chr6:86472559 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.67 -0.34 1.08e-10 Response to antipsychotic treatment; LUSC trans rs7824557 0.510 rs4841524 chr8:11243126 C/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.04 -0.4 1.62e-14 Retinal vascular caliber; LUSC cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg27446573 chr6:127587934 RNF146 0.92 15.21 0.64 4.64e-40 Breast cancer; LUSC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.63 -0.43 2.63e-16 Lung cancer; LUSC cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg05043794 chr9:111880884 C9orf5 -0.37 -7.81 -0.39 7.29e-14 Menarche (age at onset); LUSC cis rs7945705 0.846 rs905290 chr11:8753729 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.33 6.25 0.32 1.25e-9 Hemoglobin concentration; LUSC cis rs72781680 0.566 rs72796106 chr2:23901362 A/C cg08917208 chr2:24149416 ATAD2B 0.81 8.73 0.43 1.28e-16 Lymphocyte counts; LUSC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg15147215 chr3:52552868 STAB1 -0.32 -6.35 -0.33 7.09e-10 Electroencephalogram traits; LUSC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg23649088 chr2:200775458 C2orf69 0.54 7.37 0.37 1.38e-12 Schizophrenia; LUSC cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg23649088 chr2:200775458 C2orf69 -0.53 -6.82 -0.35 4.37e-11 Schizophrenia; LUSC cis rs10986311 0.802 rs6478659 chr9:127128274 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.43 -6.85 -0.35 3.65e-11 Vitiligo; LUSC cis rs2120019 0.935 rs34835684 chr15:75331805 T/G cg09165964 chr15:75287851 SCAMP5 -1.15 -18.88 -0.72 1.33e-54 Blood trace element (Zn levels); LUSC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg24578937 chr1:2090814 PRKCZ -0.45 -9.83 -0.47 3.43e-20 Height; LUSC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -5.68 -0.3 2.86e-8 Major depressive disorder; LUSC trans rs2262909 0.962 rs11667209 chr19:22259467 A/G cg17074339 chr11:11642133 GALNTL4 0.47 7.17 0.37 4.94e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs11105298 0.891 rs1054807 chr12:89913419 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.35 -0.37 1.52e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19901994 chr8:27288146 PTK2B 0.46 6.77 0.35 5.64e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11039100 0.850 rs12363855 chr11:5830186 G/C cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6580649 0.941 rs72644845 chr12:48503881 G/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.1 -0.32 2.9e-9 Lung cancer; LUSC cis rs611744 0.647 rs11774904 chr8:109273435 G/A cg21045802 chr8:109455806 TTC35 0.44 6.89 0.35 2.85e-11 Dupuytren's disease; LUSC cis rs75920871 0.588 rs10892055 chr11:116868371 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.76 -0.35 6.07e-11 Subjective well-being; LUSC cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg02466173 chr16:30829666 NA -0.6 -11.14 -0.52 1.05e-24 Multiple myeloma; LUSC cis rs2279817 0.735 rs71644064 chr1:18000044 G/A cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.2 -0.32 1.71e-9 Neuroticism; LUSC cis rs6500602 0.727 rs11644481 chr16:4581002 T/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.63 0.39 2.47e-13 Schizophrenia; LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 13.81 0.6 1.2e-34 Platelet count; LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2652834 0.851 rs2652792 chr15:63411492 G/C cg05507819 chr15:63340323 TPM1 0.46 5.94 0.31 7.3e-9 HDL cholesterol; LUSC cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs6665290 0.904 rs1045290 chr1:227178700 A/G cg10327440 chr1:227177885 CDC42BPA -1.21 -40.51 -0.91 6.17e-131 Myeloid white cell count; LUSC cis rs9815354 0.556 rs60966614 chr3:42005166 A/G cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs4660306 1.000 rs2993259 chr1:46001550 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -6.9 -0.35 2.61e-11 Homocysteine levels; LUSC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg02487422 chr3:49467188 NICN1 0.43 6.86 0.35 3.36e-11 Parkinson's disease; LUSC cis rs931127 0.692 rs7934517 chr11:65445673 C/T cg05805236 chr11:65401703 PCNXL3 -0.42 -7.34 -0.37 1.62e-12 Systemic lupus erythematosus; LUSC cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg12823233 chr7:2316876 SNX8 -0.36 -6.02 -0.31 4.7e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.6 0.65 1.31e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs12762955 0.561 rs7075141 chr10:1091195 C/T cg26597838 chr10:835615 NA -0.44 -6.24 -0.32 1.3e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs7020830 0.898 rs7857936 chr9:37078491 T/C cg14294708 chr9:37120828 ZCCHC7 1.07 23.37 0.79 3e-72 Schizophrenia; LUSC cis rs7605827 0.930 rs11900088 chr2:15613994 T/C cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg00359181 chr2:38893519 GALM -0.49 -5.79 -0.3 1.63e-8 5-HTT brain serotonin transporter levels; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg12564285 chr5:131593104 PDLIM4 0.43 8.42 0.42 1.09e-15 Blood metabolite levels; LUSC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg21285383 chr16:89894308 SPIRE2 0.31 6.62 0.34 1.42e-10 Vitiligo; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03905905 chr2:63277850 OTX1 -0.4 -6.01 -0.31 4.94e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg15147215 chr3:52552868 STAB1 -0.31 -6.09 -0.32 3.09e-9 Bipolar disorder; LUSC cis rs5758659 0.714 rs2413668 chr22:42505841 G/A cg15557168 chr22:42548783 NA 0.35 5.86 0.31 1.11e-8 Cognitive function; LUSC cis rs1908814 0.503 rs34657250 chr8:11795373 A/G cg21775007 chr8:11205619 TDH -0.47 -6.67 -0.34 1.06e-10 Neuroticism; LUSC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg13770153 chr20:60521292 NA -0.47 -6.85 -0.35 3.55e-11 Body mass index; LUSC cis rs951366 0.538 rs3761919 chr1:205694720 G/A cg07167872 chr1:205819463 PM20D1 -0.43 -5.89 -0.31 9.36e-9 Menarche (age at onset); LUSC cis rs2797160 1.000 rs78602343 chr6:126019768 T/C cg05901451 chr6:126070800 HEY2 0.57 8.51 0.42 5.79e-16 Endometrial cancer; LUSC cis rs11690935 0.788 rs10201053 chr2:172889558 A/G cg13550731 chr2:172543902 DYNC1I2 -0.76 -12.05 -0.55 5.09e-28 Schizophrenia; LUSC cis rs3771570 1.000 rs3771564 chr2:242355701 G/A cg21155796 chr2:242212141 HDLBP 0.59 6.36 0.33 6.69e-10 Prostate cancer; LUSC cis rs7582720 0.511 rs116219813 chr2:204081675 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.29 0.41 2.71e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg14552801 chr7:65878734 NA -0.37 -5.64 -0.3 3.53e-8 Aortic root size; LUSC cis rs10779751 0.960 rs2076657 chr1:11318763 C/G cg08854313 chr1:11322531 MTOR 0.92 16.17 0.66 7.91e-44 Body mass index; LUSC cis rs427941 0.632 rs201503 chr7:101759595 C/G cg06246474 chr7:101738831 CUX1 0.4 6.65 0.34 1.18e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC trans rs7819412 0.775 rs4841489 chr8:10936811 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.39 -0.37 1.19e-12 Triglycerides; LUSC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs1595825 0.891 rs6733834 chr2:198518709 C/G cg19156104 chr2:198669113 PLCL1 0.46 5.69 0.3 2.73e-8 Ulcerative colitis; LUSC cis rs12458462 0.665 rs2035085 chr18:77485280 C/T cg11879182 chr18:77439856 CTDP1 0.69 10.41 0.49 3.74e-22 Monocyte count; LUSC cis rs7119167 0.673 rs61131329 chr11:73029269 C/G cg17517138 chr11:73019481 ARHGEF17 0.49 5.72 0.3 2.33e-8 Blood protein levels; LUSC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg19748678 chr4:122722346 EXOSC9 0.49 7.57 0.38 3.59e-13 Type 2 diabetes; LUSC cis rs977987 0.806 rs7199132 chr16:75450039 C/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.66 -0.34 1.15e-10 Dupuytren's disease; LUSC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg16680214 chr1:154839983 KCNN3 -0.52 -9.48 -0.46 4.88e-19 Prostate cancer; LUSC cis rs10779751 0.734 rs1148485 chr1:11148759 G/A cg08854313 chr1:11322531 MTOR 0.86 12.37 0.56 3.55e-29 Body mass index; LUSC cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg14584255 chr6:163149320 PACRG;PARK2 -0.34 -6.6 -0.34 1.66e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg14019146 chr3:50243930 SLC38A3 0.31 6.91 0.35 2.48e-11 Intelligence (multi-trait analysis); LUSC cis rs4730250 0.707 rs257382 chr7:106804249 A/G cg02696742 chr7:106810147 HBP1 -0.63 -8.79 -0.43 7.83e-17 Osteoarthritis; LUSC cis rs7937682 0.681 rs2156580 chr11:111394328 C/G cg09085632 chr11:111637200 PPP2R1B 0.52 6.86 0.35 3.28e-11 Primary sclerosing cholangitis; LUSC trans rs11098499 0.738 rs28408407 chr4:120376030 C/G cg25214090 chr10:38739885 LOC399744 0.54 8.06 0.4 1.37e-14 Corneal astigmatism; LUSC trans rs10506458 0.915 rs12426017 chr12:63396272 T/G cg22491629 chr6:157744540 C6orf35 -0.9 -10.83 -0.51 1.29e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg20891283 chr12:69753455 YEATS4 0.81 14.65 0.63 7.13e-38 Blood protein levels; LUSC cis rs1018836 0.651 rs2339175 chr8:91565805 A/T cg16814680 chr8:91681699 NA -0.76 -12.7 -0.57 2.07e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs568617 1.000 rs568617 chr11:65653242 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.5 6.03 0.31 4.42e-9 Crohn's disease; LUSC cis rs7615952 1.000 rs9289275 chr3:125648659 A/T cg05084668 chr3:125655381 ALG1L -0.81 -12.37 -0.56 3.54e-29 Blood pressure (smoking interaction); LUSC cis rs2204008 0.549 rs12312109 chr12:38228251 G/T cg13010199 chr12:38710504 ALG10B -0.48 -7.22 -0.37 3.45e-12 Bladder cancer; LUSC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg04450456 chr4:17643702 FAM184B 0.42 7.16 0.36 5.27e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9976767 0.637 rs2277799 chr21:43824123 G/C cg20516845 chr21:43823604 UBASH3A -0.25 -5.76 -0.3 1.9e-8 Type 1 diabetes; LUSC cis rs1322639 1.000 rs9689079 chr6:169587148 A/G cg04662567 chr6:169592167 NA 0.4 5.93 0.31 7.54e-9 Pulse pressure; LUSC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg12751644 chr20:60527061 NA -0.34 -6.06 -0.31 3.59e-9 Body mass index; LUSC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg06112835 chr11:68658793 MRPL21 0.52 8.08 0.4 1.21e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg03465714 chr1:152285911 FLG -0.36 -6.42 -0.33 4.65e-10 Inflammatory skin disease; LUSC cis rs9372253 0.645 rs7753212 chr6:110700229 T/C cg19196401 chr6:110721138 DDO -0.41 -7.67 -0.39 1.88e-13 Platelet distribution width; LUSC cis rs6596100 0.500 rs67685368 chr5:132292946 T/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Breast cancer; LUSC cis rs6545883 0.894 rs6545845 chr2:61437044 G/C cg15711740 chr2:61764176 XPO1 0.44 6.7 0.34 8.96e-11 Tuberculosis; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg08888203 chr3:10149979 C3orf24 0.64 8.95 0.44 2.55e-17 Alzheimer's disease; LUSC cis rs11098499 0.954 rs10008459 chr4:120394231 T/C cg24375607 chr4:120327624 NA 0.81 12.0 0.55 8.02e-28 Corneal astigmatism; LUSC cis rs208520 0.690 rs866452 chr6:66849936 A/T cg07460842 chr6:66804631 NA -1.12 -17.44 -0.69 7.25e-49 Exhaled nitric oxide output; LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18099408 chr3:52552593 STAB1 -0.41 -6.96 -0.36 1.84e-11 Bipolar disorder; LUSC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg07424592 chr7:64974309 NA 0.64 5.74 0.3 2.1e-8 Diabetic kidney disease; LUSC trans rs6502050 0.835 rs4789744 chr17:80101506 A/C cg07393940 chr7:158741817 NA 0.36 6.57 0.34 1.98e-10 Life satisfaction; LUSC cis rs9916302 0.904 rs7221875 chr17:37543328 G/A cg07936489 chr17:37558343 FBXL20 0.7 9.64 0.47 1.44e-19 Glomerular filtration rate (creatinine); LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg07157834 chr1:205819609 PM20D1 0.86 15.44 0.65 5.83e-41 Menarche (age at onset); LUSC cis rs6840360 0.934 rs6817058 chr4:152603865 T/C cg22705602 chr4:152727874 NA -0.27 -5.67 -0.3 3.02e-8 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.836 rs745849 chr20:33572178 G/A cg07148914 chr20:33460835 GGT7 -0.45 -6.63 -0.34 1.32e-10 Height; LUSC cis rs4073416 0.568 rs1999725 chr14:65904237 C/T cg03016385 chr14:66212404 NA -0.4 -6.5 -0.34 2.95e-10 N-glycan levels; LUSC cis rs1577917 0.958 rs12193904 chr6:86452703 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.85 -0.44 5.09e-17 Response to antipsychotic treatment; LUSC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg13939156 chr17:80058883 NA -0.33 -6.42 -0.33 4.68e-10 Life satisfaction; LUSC cis rs735539 1.000 rs9506537 chr13:21280410 T/C cg04906043 chr13:21280425 IL17D 0.45 8.62 0.43 2.75e-16 Dental caries; LUSC cis rs637571 0.544 rs55704213 chr11:65730002 C/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 9.63 0.47 1.53e-19 Eosinophil percentage of white cells; LUSC trans rs7613875 0.600 rs2247510 chr3:50126215 A/C cg21659725 chr3:3221576 CRBN 0.51 7.93 0.4 3.41e-14 Body mass index; LUSC cis rs400736 0.729 rs9434949 chr1:8006083 C/G cg25007680 chr1:8021821 PARK7 -0.5 -7.33 -0.37 1.8e-12 Response to antidepressants and depression; LUSC cis rs9309473 0.607 rs2421488 chr2:73590625 C/T cg20560298 chr2:73613845 ALMS1 -0.55 -8.24 -0.41 3.84e-15 Metabolite levels; LUSC cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg05347473 chr6:146136440 FBXO30 0.41 6.97 0.36 1.67e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9309473 1.000 rs60844734 chr2:73623205 T/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.83 -0.35 3.95e-11 Metabolite levels; LUSC cis rs6500602 0.893 rs6500601 chr16:4497199 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.4 7.94 0.4 3.05e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg03676636 chr4:99064102 C4orf37 0.36 7.85 0.39 5.64e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.518 rs13133925 chr4:98706398 G/T cg17366294 chr4:99064904 C4orf37 0.55 8.67 0.43 1.95e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs17780086 0.529 rs7406406 chr17:30220153 T/G cg13647721 chr17:30228624 UTP6 0.69 9.19 0.45 4.44e-18 Height; LUSC cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg23711669 chr6:146136114 FBXO30 -0.83 -14.97 -0.63 3.94e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs61931739 0.517 rs12815556 chr12:34319670 G/A cg06521331 chr12:34319734 NA -0.48 -8.04 -0.4 1.53e-14 Morning vs. evening chronotype; LUSC cis rs62244186 0.545 rs9284880 chr3:44759389 C/T cg16615211 chr3:44902933 MIR564;TMEM42 0.36 6.18 0.32 1.87e-9 Depressive symptoms; LUSC cis rs514406 0.536 rs878957 chr1:53197559 C/T cg08859206 chr1:53392774 SCP2 0.52 9.14 0.45 6.18e-18 Monocyte count; LUSC cis rs3126085 0.935 rs4845740 chr1:152183310 G/A cg03465714 chr1:152285911 FLG -0.41 -5.76 -0.3 1.96e-8 Atopic dermatitis; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg04141948 chr7:1023156 CYP2W1 0.3 6.31 0.33 8.81e-10 Longevity;Endometriosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24222746 chr2:148779348 ORC4L 0.4 6.25 0.32 1.26e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg16615211 chr3:44902933 MIR564;TMEM42 0.36 6.49 0.33 3.05e-10 Depressive symptoms; LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg08736216 chr1:53307985 ZYG11A 0.3 6.28 0.33 1.04e-9 Monocyte count; LUSC cis rs2200578 1.000 rs7566277 chr2:99916242 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 0.56 6.37 0.33 6.27e-10 IgG glycosylation; LUSC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs4363385 0.818 rs61811862 chr1:152995668 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.11 -0.36 7.08e-12 Inflammatory skin disease; LUSC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg18876405 chr7:65276391 NA -0.7 -12.5 -0.56 1.1e-29 Aortic root size; LUSC cis rs9296095 0.796 rs3846855 chr6:33555877 G/A cg14003231 chr6:33640908 ITPR3 0.53 8.06 0.4 1.35e-14 Platelet count; LUSC cis rs1461503 0.966 rs11218905 chr11:122840303 A/G cg27398637 chr11:122830231 C11orf63 0.4 6.39 0.33 5.44e-10 Menarche (age at onset); LUSC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg08975724 chr8:8085496 FLJ10661 -0.51 -7.73 -0.39 1.25e-13 Mood instability; LUSC cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg04359828 chr10:32216031 ARHGAP12 0.38 6.52 0.34 2.59e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9815354 0.812 rs73071242 chr3:41993011 T/C cg03022575 chr3:42003672 ULK4 0.85 8.86 0.44 4.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs1568889 1.000 rs12797689 chr11:28076042 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 8.94 0.44 2.63e-17 Bipolar disorder; LUSC cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.64 0.34 1.28e-10 Educational attainment; LUSC cis rs2267681 0.583 rs764746 chr7:139530089 G/A cg14116596 chr7:139528673 TBXAS1 0.36 6.23 0.32 1.42e-9 Cervical cancer; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg16405210 chr4:1374714 KIAA1530 -0.54 -8.28 -0.41 2.93e-15 Obesity-related traits; LUSC cis rs6964587 1.000 rs10228334 chr7:91713972 C/T cg22709100 chr7:91322751 NA 0.4 5.9 0.31 8.7e-9 Breast cancer; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.38 -6.01 -0.31 4.73e-9 Longevity;Endometriosis; LUSC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg14895029 chr7:2775587 GNA12 -0.36 -5.82 -0.3 1.35e-8 Height; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg08280861 chr8:58055591 NA 0.54 6.39 0.33 5.52e-10 Developmental language disorder (linguistic errors); LUSC cis rs4555082 0.915 rs66527719 chr14:105750523 C/G cg06808227 chr14:105710500 BRF1 -0.61 -8.92 -0.44 3.08e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs3806843 1.000 rs6891995 chr5:140172008 A/G cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.43e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs76878669 0.538 rs1785633 chr11:66107527 C/A cg18002602 chr11:66138449 SLC29A2 0.47 8.52 0.42 5.65e-16 Educational attainment (years of education); LUSC cis rs9462027 0.628 rs7739771 chr6:34779801 C/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs72781680 0.846 rs72780198 chr2:24014883 T/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.91 0.4 3.79e-14 Blood metabolite levels; LUSC trans rs2825388 0.965 rs9975959 chr21:20549004 A/G cg18565711 chr19:55870393 FAM71E2 0.26 6.04 0.31 4.05e-9 Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction); LUSC trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg04842962 chr6:43655489 MRPS18A 0.91 14.78 0.63 2.13e-38 IgG glycosylation; LUSC cis rs9487051 0.735 rs352837 chr6:109521806 C/T cg01475377 chr6:109611718 NA 0.35 6.06 0.31 3.67e-9 Reticulocyte fraction of red cells; LUSC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg04315214 chr1:2043799 PRKCZ -0.4 -8.13 -0.41 8.65e-15 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26316697 chr12:56727976 PAN2 -0.44 -6.03 -0.31 4.36e-9 Hepatitis; LUSC cis rs2580764 0.566 rs2968793 chr2:55285024 C/T cg09592903 chr2:55203963 RTN4 0.47 9.49 0.46 4.65e-19 Mean platelet volume; LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg27535305 chr1:53392650 SCP2 0.36 6.66 0.34 1.13e-10 Monocyte count; LUSC cis rs977987 0.843 rs59465235 chr16:75483810 C/G cg03315344 chr16:75512273 CHST6 0.54 10.42 0.5 3.45e-22 Dupuytren's disease; LUSC trans rs11098499 0.955 rs1511018 chr4:120161580 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.19 0.32 1.8e-9 Corneal astigmatism; LUSC cis rs668210 0.793 rs1192184 chr11:65773382 A/G cg04700828 chr11:65773979 NA 0.4 5.72 0.3 2.35e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs9388451 0.839 rs10457469 chr6:126083658 G/A cg10911889 chr6:126070802 HEY2 0.42 6.43 0.33 4.48e-10 Brugada syndrome; LUSC cis rs3857536 0.813 rs9294688 chr6:66945904 C/T cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs2281558 0.833 rs12480853 chr20:25522959 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.62 9.33 0.45 1.52e-18 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg19077165 chr18:44547161 KATNAL2 -0.4 -5.86 -0.31 1.12e-8 Personality dimensions; LUSC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg07701084 chr6:150067640 NUP43 0.53 7.75 0.39 1.14e-13 Lung cancer; LUSC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg23887609 chr12:130822674 PIWIL1 -0.48 -7.08 -0.36 8.43e-12 Menopause (age at onset); LUSC cis rs911119 0.913 rs6106685 chr20:23581612 A/C cg16589663 chr20:23618590 CST3 0.62 7.41 0.38 1.04e-12 Chronic kidney disease; LUSC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg04518342 chr5:131593106 PDLIM4 -0.31 -5.65 -0.3 3.48e-8 Blood metabolite levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01304814 chr3:48885189 PRKAR2A 0.46 6.4 0.33 5.31e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4629710 0.592 rs66533103 chr6:131531016 C/T cg12700074 chr6:131571435 AKAP7 -0.37 -6.01 -0.31 4.9e-9 Multiple myeloma (IgH translocation); LUSC cis rs9868809 0.881 rs34368826 chr3:48670827 G/T cg00383909 chr3:49044727 WDR6 1.07 9.61 0.47 1.86e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs6840360 1.000 rs2278304 chr4:152593409 C/T cg22705602 chr4:152727874 NA 0.27 5.77 0.3 1.85e-8 Intelligence (multi-trait analysis); LUSC trans rs11782517 0.924 rs35474349 chr8:10109654 C/T cg15556689 chr8:8085844 FLJ10661 0.48 6.02 0.31 4.5e-9 Nose size; LUSC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.83 13.38 0.59 5.27e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs72781680 0.898 rs7589440 chr2:24038595 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg06550200 chr5:1325588 CLPTM1L 0.62 10.55 0.5 1.22e-22 Lung cancer; LUSC cis rs7267979 1.000 rs6050626 chr20:25428261 T/C cg08601574 chr20:25228251 PYGB 0.43 6.54 0.34 2.25e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6977660 0.619 rs12534026 chr7:19788687 T/C cg05791153 chr7:19748676 TWISTNB 0.64 7.2 0.37 4.03e-12 Thyroid stimulating hormone; LUSC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg22508957 chr16:3507546 NAT15 0.47 6.51 0.34 2.82e-10 Body mass index (adult); LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 15.78 0.65 2.56e-42 Platelet count; LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 14.27 0.62 2.15e-36 Platelet count; LUSC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg04511125 chr2:88470314 THNSL2 0.97 9.55 0.46 2.87e-19 Plasma clusterin levels; LUSC cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.46e-12 Motion sickness; LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg04518342 chr5:131593106 PDLIM4 0.5 8.88 0.44 4.09e-17 Acylcarnitine levels; LUSC trans rs13011075 0.919 rs10496165 chr2:68620089 C/T cg14221825 chr19:46271408 SIX5 0.42 6.08 0.32 3.38e-9 Mean corpuscular volume; LUSC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg04455712 chr21:45112962 RRP1B -0.45 -8.42 -0.42 1.09e-15 Mean corpuscular volume; LUSC cis rs2273669 0.667 rs6918331 chr6:109317394 C/G cg05315195 chr6:109294784 ARMC2 -0.53 -5.94 -0.31 7.15e-9 Prostate cancer; LUSC cis rs7843479 0.932 rs68023663 chr8:21794379 T/C cg17168535 chr8:21777572 XPO7 0.7 11.12 0.52 1.21e-24 Mean corpuscular volume; LUSC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.18 -0.32 1.92e-9 Total body bone mineral density; LUSC trans rs56114371 0.777 rs200481 chr6:27773832 A/T cg01620082 chr3:125678407 NA -0.66 -7.02 -0.36 1.28e-11 Breast cancer; LUSC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg04871131 chr7:94954202 PON1 -0.38 -6.1 -0.32 2.98e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs56804039 1.000 rs67611618 chr8:8380939 T/C cg06636001 chr8:8085503 FLJ10661 -0.52 -6.27 -0.32 1.12e-9 Cervical cancer; LUSC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg21017887 chr14:105400489 NA 0.69 12.97 0.58 1.93e-31 Rheumatoid arthritis; LUSC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg18404041 chr3:52824283 ITIH1 -0.44 -7.47 -0.38 7.24e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Bone mineral density; LUSC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg00255919 chr5:131827918 IRF1 -0.44 -8.38 -0.42 1.53e-15 Asthma (sex interaction); LUSC cis rs35883536 0.647 rs12043865 chr1:101042651 G/A cg06223162 chr1:101003688 GPR88 -0.48 -9.03 -0.44 1.4e-17 Monocyte count; LUSC cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg22681709 chr2:178499509 PDE11A -0.34 -6.19 -0.32 1.72e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs4363385 0.740 rs1697428 chr1:153015761 C/A cg00922841 chr1:152955080 SPRR1A -0.46 -8.11 -0.41 9.53e-15 Inflammatory skin disease; LUSC cis rs877282 0.945 rs35342920 chr10:790484 T/C cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg12564285 chr5:131593104 PDLIM4 -0.38 -7.02 -0.36 1.27e-11 Blood metabolite levels; LUSC cis rs17102423 0.755 rs4902358 chr14:65542477 A/G cg11161011 chr14:65562177 MAX -0.79 -11.83 -0.54 3.32e-27 Obesity-related traits; LUSC cis rs977987 0.836 rs7198873 chr16:75474754 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.21 -0.37 3.89e-12 Dupuytren's disease; LUSC cis rs7937682 0.889 rs12360825 chr11:111528786 A/T cg09085632 chr11:111637200 PPP2R1B -1.08 -17.04 -0.68 2.7e-47 Primary sclerosing cholangitis; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.71 11.95 0.55 1.2e-27 Prudent dietary pattern; LUSC cis rs1018836 0.923 rs62526886 chr8:91627676 G/A cg16814680 chr8:91681699 NA -0.77 -12.99 -0.58 1.66e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg01657329 chr11:68192670 LRP5 -0.44 -6.65 -0.34 1.21e-10 Total body bone mineral density; LUSC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg14196790 chr5:131705035 SLC22A5 0.48 8.08 0.4 1.24e-14 Blood metabolite levels; LUSC cis rs1461503 0.511 rs4129007 chr11:122811812 T/C cg27398637 chr11:122830231 C11orf63 -0.39 -6.47 -0.33 3.55e-10 Menarche (age at onset); LUSC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Vitiligo; LUSC cis rs6700896 0.500 rs12024269 chr1:66103674 G/T cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.29 0.33 9.97e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs17001868 0.568 rs55769635 chr22:40790101 G/A cg07138101 chr22:40742427 ADSL 0.61 7.5 0.38 5.72e-13 Mammographic density (dense area); LUSC cis rs2354432 0.556 rs2353984 chr1:146813358 C/T cg25205988 chr1:146714368 CHD1L 0.89 8.69 0.43 1.64e-16 Mitochondrial DNA levels; LUSC cis rs6987853 0.787 rs2923405 chr8:42448126 T/G cg09913449 chr8:42400586 C8orf40 0.5 8.7 0.43 1.52e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.59 0.46 2.1e-19 Breast cancer; LUSC cis rs2692947 0.673 rs2917662 chr2:96794957 G/A cg23100626 chr2:96804247 ASTL 0.3 7.17 0.37 4.93e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9462027 0.583 rs9469902 chr6:34793768 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.76 -0.3 1.86e-8 Systemic lupus erythematosus; LUSC cis rs10131894 0.611 rs174995 chr14:75434183 T/C cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.35 -0.42 1.88e-15 Coronary artery disease; LUSC cis rs1577917 0.771 rs4441928 chr6:86241894 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 10.4 0.49 3.88e-22 Response to antipsychotic treatment; LUSC cis rs9790314 1.000 rs6441373 chr3:161026717 T/G cg04691961 chr3:161091175 C3orf57 -0.35 -5.99 -0.31 5.34e-9 Morning vs. evening chronotype; LUSC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg00750074 chr16:89608354 SPG7 0.49 8.81 0.43 6.94e-17 Multiple myeloma (IgH translocation); LUSC cis rs2073300 1.000 rs6106655 chr20:23441982 C/G cg09953122 chr20:23471693 CST8 -0.77 -6.62 -0.34 1.46e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs28647808 0.881 rs4549850 chr9:136265239 T/C cg12569217 chr2:109379859 RANBP2 0.6 5.95 0.31 6.83e-9 Blood protein levels; LUSC cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg03517284 chr6:25882590 NA -0.52 -9.67 -0.47 1.16e-19 Blood metabolite levels; LUSC cis rs2857891 0.817 rs1907611 chr11:6968302 A/G cg14883916 chr11:6947541 ZNF215 0.44 6.0 0.31 5.28e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg19346786 chr7:2764209 NA -0.48 -8.11 -0.41 1e-14 Height; LUSC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg05340658 chr4:99064831 C4orf37 -0.67 -11.52 -0.53 4.27e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6542838 0.698 rs7565736 chr2:99464952 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.17 -0.32 2.01e-9 Fear of minor pain; LUSC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.51 0.53 4.8e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs1941023 0.503 rs4528348 chr11:60129505 C/G cg08716584 chr11:60157161 MS4A7 -0.61 -11.47 -0.53 6.92e-26 Congenital heart disease (maternal effect); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27523423 chr15:75744089 SIN3A 0.39 5.99 0.31 5.48e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10098647 0.547 rs10086417 chr8:61111078 C/T cg09970348 chr3:183978600 ECE2;CAMK2N2 0.46 6.15 0.32 2.26e-9 Obesity-related traits; LUSC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg16325326 chr1:53192061 ZYG11B 0.82 14.09 0.61 1.07e-35 Monocyte count; LUSC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg17385448 chr1:15911702 AGMAT 0.37 6.32 0.33 8.16e-10 Systolic blood pressure; LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18099408 chr3:52552593 STAB1 -0.42 -7.07 -0.36 9.06e-12 Bipolar disorder; LUSC cis rs28655083 1.000 rs1843456 chr16:77072393 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.38 -5.66 -0.3 3.32e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs8017423 0.967 rs11159958 chr14:90716051 T/C cg04374321 chr14:90722782 PSMC1 0.75 12.0 0.55 8.19e-28 Mortality in heart failure; LUSC cis rs10464366 0.560 rs12672089 chr7:39132816 G/A cg10621924 chr7:39171070 POU6F2 0.44 6.84 0.35 3.75e-11 IgG glycosylation; LUSC cis rs1775715 0.737 rs2799031 chr10:32173168 C/T cg04359828 chr10:32216031 ARHGAP12 0.4 6.9 0.35 2.69e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9584850 0.834 rs7334078 chr13:99120484 C/T cg20487152 chr13:99095054 FARP1 -0.34 -5.64 -0.3 3.57e-8 Neuroticism; LUSC cis rs9858542 1.000 rs9836291 chr3:49697459 G/A cg07274523 chr3:49395745 GPX1 0.62 9.41 0.46 8.46e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs4319547 0.774 rs7954006 chr12:123131824 A/C cg05707623 chr12:122985044 ZCCHC8 0.54 7.5 0.38 5.63e-13 Body mass index; LUSC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs35000415 0.745 rs117473643 chr7:128698186 G/C cg19972273 chr7:128594194 NA 0.63 5.72 0.3 2.34e-8 Systemic lupus erythematosus; LUSC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg15557168 chr22:42548783 NA -0.37 -6.27 -0.32 1.11e-9 Cognitive function; LUSC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg07936489 chr17:37558343 FBXL20 0.73 10.0 0.48 9.44e-21 Glomerular filtration rate (creatinine); LUSC cis rs17095355 1.000 rs12570230 chr10:111691614 T/C cg00817464 chr10:111662876 XPNPEP1 -0.56 -6.81 -0.35 4.65e-11 Biliary atresia; LUSC trans rs9929218 0.954 rs4552018 chr16:68822854 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.09 -0.52 1.52e-24 Colorectal cancer; LUSC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12476592 0.543 rs262470 chr2:63830559 C/T cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs7223966 1.000 rs16947042 chr17:61766457 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.34 0.37 1.64e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg06634786 chr22:41940651 POLR3H 0.5 6.04 0.31 4.05e-9 Vitiligo; LUSC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg21854759 chr1:92012499 NA -0.44 -7.01 -0.36 1.29e-11 Breast cancer; LUSC cis rs3737883 1.000 rs11579055 chr1:203031315 G/T cg00805880 chr1:203045044 PPFIA4 -0.29 -5.84 -0.3 1.27e-8 Early onset atrial fibrillation; LUSC cis rs4319547 0.695 rs10734915 chr12:122873408 A/C cg23029597 chr12:123009494 RSRC2 -0.68 -8.8 -0.43 7.39e-17 Body mass index; LUSC cis rs4900538 0.963 rs1190554 chr14:102918686 T/C cg18135206 chr14:102964638 TECPR2 0.99 19.66 0.73 1.06e-57 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4692589 0.581 rs6821641 chr4:170960193 C/T cg19918862 chr4:170955249 NA 0.36 6.64 0.34 1.26e-10 Anxiety disorder; LUSC cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg03146154 chr1:46216737 IPP 0.5 7.49 0.38 6.06e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7712401 0.601 rs4555798 chr5:122332114 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.2 -0.45 4.07e-18 Mean platelet volume; LUSC cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg13256891 chr4:100009986 ADH5 0.43 6.21 0.32 1.57e-9 Alcohol dependence; LUSC cis rs870825 0.616 rs6552810 chr4:185644143 G/A cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.74 -0.39 1.19e-13 Chronic sinus infection; LUSC cis rs12042938 0.507 rs1765777 chr1:231731742 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.71 -11.61 -0.54 2.08e-26 Neuranatomic and neurocognitive phenotypes; LUSC cis rs7927592 0.830 rs10896339 chr11:68302846 G/C cg01657329 chr11:68192670 LRP5 -0.45 -6.76 -0.35 6.32e-11 Total body bone mineral density; LUSC cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg13334819 chr7:99746414 C7orf59 -0.44 -5.88 -0.31 1.01e-8 Coronary artery disease; LUSC cis rs4812048 0.649 rs6070706 chr20:57628239 C/T cg14073986 chr20:57617431 SLMO2 0.91 9.55 0.46 2.78e-19 Mean platelet volume; LUSC cis rs12618769 0.652 rs3754875 chr2:99202747 C/G cg10123293 chr2:99228465 UNC50 0.46 7.34 0.37 1.63e-12 Bipolar disorder; LUSC trans rs6445967 0.689 rs11714574 chr3:58380465 A/T cg14253670 chr8:24802149 NA 0.27 6.16 0.32 2.12e-9 Platelet count; LUSC cis rs733592 0.504 rs2261608 chr12:48721634 A/T cg24011408 chr12:48396354 COL2A1 0.46 7.66 0.39 1.97e-13 Plateletcrit; LUSC cis rs13401104 0.796 rs11680754 chr2:237112384 T/C cg19324714 chr2:237145437 ASB18 0.43 5.71 0.3 2.46e-8 Educational attainment; LUSC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg01802117 chr1:53393560 SCP2 0.39 6.36 0.33 6.52e-10 Monocyte count; LUSC cis rs2439831 0.867 rs2614811 chr15:43913487 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.95 0.36 1.88e-11 Lung cancer in ever smokers; LUSC cis rs6076065 0.723 rs6137909 chr20:23344728 A/G cg11657817 chr20:23433608 CST11 0.44 8.18 0.41 6.2e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.13 -0.45 6.87e-18 Gut microbiome composition (summer); LUSC cis rs72777070 0.652 rs10185981 chr2:9795382 C/T cg14973360 chr2:9800511 NA -0.39 -5.77 -0.3 1.84e-8 Platelet-derived growth factor BB levels; LUSC trans rs66887589 0.592 rs62320740 chr4:120279486 C/A cg25214090 chr10:38739885 LOC399744 0.41 6.57 0.34 1.89e-10 Diastolic blood pressure; LUSC cis rs34172651 0.917 rs1075987 chr16:24794957 G/A cg00339695 chr16:24857497 SLC5A11 0.37 6.59 0.34 1.72e-10 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg05347473 chr6:146136440 FBXO30 0.45 7.69 0.39 1.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9650315 0.866 rs67752445 chr8:57182034 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.8 0.35 4.85e-11 Height; LUSC cis rs1570884 0.556 rs2146146 chr13:50170368 C/T cg08779649 chr13:50194554 NA 0.4 6.83 0.35 3.95e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg08219700 chr8:58056026 NA -0.68 -7.84 -0.39 6.16e-14 Developmental language disorder (linguistic errors); LUSC trans rs1493916 0.837 rs9949631 chr18:31410567 G/A cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs11822910 0.737 rs2581924 chr11:57208468 C/T cg00522883 chr11:57194120 SLC43A3 0.41 6.74 0.35 7.09e-11 Platelet distribution width; LUSC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs453301 0.653 rs2956244 chr8:8885166 A/G cg06636001 chr8:8085503 FLJ10661 0.62 9.63 0.47 1.54e-19 Joint mobility (Beighton score); LUSC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg22857025 chr5:266934 NA 1.16 16.26 0.66 3.45e-44 Breast cancer; LUSC cis rs68170813 0.559 rs6964966 chr7:106933099 C/G cg02696742 chr7:106810147 HBP1 -0.65 -9.82 -0.47 3.55e-20 Coronary artery disease; LUSC cis rs7584330 0.738 rs13398506 chr2:238374824 A/G cg14458575 chr2:238380390 NA 0.66 11.37 0.53 1.48e-25 Prostate cancer; LUSC cis rs6599077 0.901 rs9854779 chr3:40092874 T/C cg13683864 chr3:40499215 RPL14 -0.6 -7.47 -0.38 7.09e-13 Sleep-related phenotypes; LUSC cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg03146154 chr1:46216737 IPP 0.52 7.75 0.39 1.14e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4462272 0.503 rs34236122 chr10:101845547 C/T cg02250046 chr10:101825185 CPN1 -0.31 -5.69 -0.3 2.8e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg05585544 chr11:47624801 NA -0.42 -7.35 -0.37 1.55e-12 Subjective well-being; LUSC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg00316803 chr15:76480434 C15orf27 -0.41 -6.97 -0.36 1.7e-11 Blood metabolite levels; LUSC cis rs477692 0.905 rs544217 chr10:131420584 A/G cg05714579 chr10:131428358 MGMT 0.52 7.9 0.4 4e-14 Response to temozolomide; LUSC cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6772849 0.930 rs4857912 chr3:128329224 G/A cg16766828 chr3:128327626 NA -0.3 -5.65 -0.3 3.47e-8 Monocyte percentage of white cells;Monocyte count; LUSC cis rs7582720 1.000 rs75869289 chr2:203806724 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs6952808 0.582 rs871925 chr7:2047875 G/A cg04565464 chr8:145669602 NFKBIL2 -0.39 -6.61 -0.34 1.51e-10 Bipolar disorder and schizophrenia; LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.59 0.6 8.31e-34 Platelet count; LUSC cis rs1775715 0.966 rs1251386 chr10:32319114 C/T cg18675610 chr10:32216311 ARHGAP12 -0.27 -5.71 -0.3 2.52e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6546537 0.869 rs35024605 chr2:69820332 A/G cg10773587 chr2:69614142 GFPT1 -0.54 -8.29 -0.41 2.87e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg19875535 chr5:140030758 IK 0.54 8.85 0.44 5.37e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs897984 0.568 rs56083427 chr16:30881298 C/T cg02466173 chr16:30829666 NA -0.53 -8.61 -0.43 2.84e-16 Dementia with Lewy bodies; LUSC cis rs765787 0.530 rs1631533 chr15:45518628 C/T cg25801113 chr15:45476975 SHF 0.35 7.3 0.37 2.15e-12 Uric acid levels; LUSC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg23172400 chr8:95962367 TP53INP1 -0.39 -8.0 -0.4 2.02e-14 Type 2 diabetes; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 12.64 0.57 3.35e-30 Prudent dietary pattern; LUSC cis rs2439831 0.702 rs3784275 chr15:44091386 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.79 6.68 0.34 1.02e-10 Lung cancer in ever smokers; LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.77 -9.84 -0.47 3.04e-20 Alzheimer's disease; LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg02951883 chr7:2050386 MAD1L1 -0.47 -8.21 -0.41 5.03e-15 Bipolar disorder and schizophrenia; LUSC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg04455712 chr21:45112962 RRP1B 0.46 8.75 0.43 1.04e-16 Mean corpuscular volume; LUSC trans rs561341 0.654 rs6505265 chr17:30172580 C/T cg20587970 chr11:113659929 NA 0.8 9.31 0.45 1.72e-18 Hip circumference adjusted for BMI; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19019321 chr2:159826400 TANC1 0.38 6.06 0.31 3.67e-9 Triglycerides; LUSC cis rs12286929 0.637 rs7125361 chr11:115080042 C/G cg04055981 chr11:115044050 NA 0.42 7.6 0.38 2.98e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs614226 0.935 rs588132 chr12:121024066 A/G cg27489772 chr12:121021490 NA 0.6 7.88 0.4 4.76e-14 Type 1 diabetes nephropathy; LUSC cis rs3018712 0.532 rs948861 chr11:68420622 C/T cg22747802 chr11:68417633 NA -0.43 -5.94 -0.31 7.02e-9 Total body bone mineral density; LUSC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg25019033 chr10:957182 NA -0.53 -6.66 -0.34 1.13e-10 Eosinophil percentage of granulocytes; LUSC cis rs1670533 1.000 rs6599279 chr4:1058833 G/A cg27284194 chr4:1044797 NA 0.59 8.66 0.43 2.08e-16 Recombination rate (females); LUSC cis rs11190604 1.000 rs7905961 chr10:102297391 G/C cg16342193 chr10:102329863 NA -0.33 -6.21 -0.32 1.56e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs921968 0.541 rs1863704 chr2:219562675 C/T cg02176678 chr2:219576539 TTLL4 -0.74 -14.27 -0.62 2.05e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.41e-9 Crohn's disease; LUSC cis rs9916302 0.706 rs12950186 chr17:37393395 A/C cg07936489 chr17:37558343 FBXL20 -0.81 -10.53 -0.5 1.36e-22 Glomerular filtration rate (creatinine); LUSC cis rs7123876 0.546 rs11604837 chr11:72360007 G/A cg04827223 chr11:72435913 ARAP1 -0.61 -6.78 -0.35 5.31e-11 Body mass index; LUSC cis rs9467711 0.606 rs9393711 chr6:26370659 C/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg08975724 chr8:8085496 FLJ10661 0.47 6.7 0.34 8.8e-11 Neuroticism; LUSC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.79 0.3 1.59e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.41 5.86 0.31 1.12e-8 Schizophrenia; LUSC cis rs17490626 0.533 rs5030925 chr10:71211150 A/C cg12610070 chr10:71211762 TSPAN15 -0.49 -9.46 -0.46 5.56e-19 Thrombosis; LUSC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.82 -0.3 1.42e-8 Depression; LUSC cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg06627628 chr2:24431161 ITSN2 -0.61 -7.4 -0.38 1.09e-12 Lymphocyte counts; LUSC cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg22676075 chr6:135203613 NA 0.57 9.13 0.45 6.87e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs2842992 0.714 rs2475564 chr6:160123673 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.05 14.99 0.63 3.26e-39 Age-related macular degeneration (geographic atrophy); LUSC trans rs6598955 0.671 rs12086573 chr1:26574330 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs12600053 0.687 rs11149686 chr16:84847247 A/G cg09249803 chr16:84846936 NA 0.29 5.97 0.31 6.13e-9 Asthma (childhood onset); LUSC cis rs2760061 0.583 rs708123 chr1:228220495 A/G cg04850211 chr1:228464232 OBSCN -0.36 -6.22 -0.32 1.51e-9 Diastolic blood pressure; LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg14004847 chr7:1930337 MAD1L1 -0.5 -7.77 -0.39 1e-13 Bipolar disorder and schizophrenia; LUSC cis rs3764021 0.870 rs10844617 chr12:9879368 G/A cg20894963 chr12:9885564 CLECL1 0.34 6.85 0.35 3.58e-11 Type 1 diabetes; LUSC trans rs9929218 0.529 rs2296404 chr16:68729525 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.05 22.63 0.78 2.07e-69 Colorectal cancer; LUSC trans rs979233 0.502 rs276265 chr5:42067881 A/T cg07010552 chr17:7358735 CHRNB1 0.41 6.03 0.31 4.33e-9 Systemic lupus erythematosus; LUSC cis rs10464366 0.879 rs10464368 chr7:39121581 C/T cg18850127 chr7:39170497 POU6F2 0.41 6.12 0.32 2.57e-9 IgG glycosylation; LUSC cis rs2404602 0.735 rs4886495 chr15:76738959 C/T cg23625390 chr15:77176239 SCAPER 0.6 9.45 0.46 6.27e-19 Blood metabolite levels; LUSC trans rs7786808 0.653 rs4909213 chr7:158202404 G/A cg02030672 chr11:45687055 CHST1 0.52 8.2 0.41 5.28e-15 Obesity-related traits; LUSC cis rs921968 0.541 rs593888 chr2:219427597 A/G cg02176678 chr2:219576539 TTLL4 0.75 14.72 0.63 3.78e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs2348418 0.864 rs6487688 chr12:28711211 A/T cg13890972 chr12:28721907 NA 0.36 6.2 0.32 1.69e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg04944784 chr2:26401820 FAM59B -0.7 -9.74 -0.47 6.73e-20 Gut microbiome composition (summer); LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg25036284 chr2:26402008 FAM59B -0.73 -10.51 -0.5 1.67e-22 Gut microbiome composition (summer); LUSC cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 8.19 0.41 5.64e-15 Lung cancer; LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.91 -0.31 8.51e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7189233 0.513 rs10748 chr16:53504721 T/C cg09728985 chr16:53543985 NA -0.33 -6.18 -0.32 1.91e-9 Intelligence (multi-trait analysis); LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg26304593 chr6:42947056 PEX6 -0.53 -8.23 -0.41 4.2e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4363385 0.818 rs2070963 chr1:153004004 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.23 -0.37 3.4e-12 Inflammatory skin disease; LUSC cis rs897984 0.542 rs7199949 chr16:31096164 G/C cg02466173 chr16:30829666 NA -0.5 -9.55 -0.46 2.91e-19 Dementia with Lewy bodies; LUSC cis rs2439831 0.681 rs528517 chr15:43612925 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.55 0.5 1.18e-22 Lung cancer in ever smokers; LUSC trans rs877282 0.853 rs12763400 chr10:763617 C/T cg22713356 chr15:30763199 NA 1.06 14.16 0.61 5.36e-36 Uric acid levels; LUSC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg05347473 chr6:146136440 FBXO30 -0.52 -9.04 -0.44 1.28e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg17340268 chr14:105411764 AHNAK2 -0.38 -6.11 -0.32 2.83e-9 Rheumatoid arthritis; LUSC cis rs8008758 0.500 rs1763212 chr14:101693911 G/A cg26224664 chr14:101693935 NA -0.37 -9.48 -0.46 4.98e-19 Body mass index (alcohol intake interaction); LUSC cis rs2885056 0.830 rs2018810 chr19:10669172 A/G cg04833646 chr19:10679720 CDKN2D 1.19 17.23 0.69 4.93e-48 Red cell distribution width; LUSC cis rs929354 0.685 rs7807856 chr7:156934498 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.44 -0.46 6.62e-19 Body mass index; LUSC cis rs7937682 0.889 rs558736 chr11:111500760 C/G cg19812747 chr11:111475976 SIK2 -0.5 -7.03 -0.36 1.15e-11 Primary sclerosing cholangitis; LUSC cis rs155346 1.000 rs2560711 chr5:139394941 T/C cg01090482 chr5:139365336 NRG2 -0.4 -6.56 -0.34 2.02e-10 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC trans rs9388451 0.839 rs9321054 chr6:126079968 A/G cg05039488 chr6:79577232 IRAK1BP1 0.6 9.61 0.47 1.9e-19 Brugada syndrome; LUSC cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.84 -0.3 1.23e-8 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg11494091 chr17:61959527 GH2 0.64 13.66 0.6 4.76e-34 Prudent dietary pattern; LUSC cis rs6940638 0.688 rs7764984 chr6:27034181 A/G cg05738196 chr6:26577821 NA -0.49 -7.05 -0.36 1.05e-11 Intelligence (multi-trait analysis); LUSC cis rs734999 0.588 rs2843403 chr1:2529097 T/C cg18854424 chr1:2615690 NA -0.52 -10.62 -0.5 6.92e-23 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10198271 chr20:55966838 RBM38 0.41 7.04 0.36 1.12e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg18099408 chr3:52552593 STAB1 0.36 6.17 0.32 1.97e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg08949735 chr16:89699720 DPEP1 -0.24 -5.89 -0.31 9.33e-9 Vitiligo; LUSC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.19 0.32 1.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs68170813 0.652 rs4730250 chr7:107207695 A/G cg02696742 chr7:106810147 HBP1 -0.65 -8.53 -0.42 5.3e-16 Coronary artery disease; LUSC cis rs2798269 1.000 rs12877509 chr13:22124028 G/C cg18095732 chr13:22033692 ZDHHC20 -0.41 -6.4 -0.33 5.32e-10 PR segment; LUSC cis rs6500395 1.000 rs9928051 chr16:48557316 T/A cg04672837 chr16:48644449 N4BP1 0.45 6.66 0.34 1.15e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.6 12.25 0.56 9.47e-29 Monocyte percentage of white cells; LUSC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg09491104 chr22:46646882 C22orf40 -0.63 -7.26 -0.37 2.76e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs4363385 0.818 rs2070963 chr1:153004004 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs7589342 0.517 rs6736701 chr2:106390440 G/T cg09152813 chr2:106391379 NCK2 -0.37 -5.91 -0.31 8.36e-9 Addiction; LUSC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg17173187 chr15:85201210 NMB 0.37 6.51 0.34 2.83e-10 Schizophrenia; LUSC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.2 -0.41 5.27e-15 Neuroticism; LUSC cis rs11148252 0.740 rs9596648 chr13:52934569 A/T cg00495681 chr13:53174319 NA -0.52 -8.02 -0.4 1.84e-14 Lewy body disease; LUSC cis rs3770081 1.000 rs56326127 chr2:86212201 G/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.03 -6.61 -0.34 1.53e-10 Facial emotion recognition (sad faces); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg12359592 chr3:138048777 TXNDC6 0.48 7.01 0.36 1.34e-11 Triglycerides; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg10684905 chr12:2999782 TULP3 -0.45 -6.48 -0.33 3.37e-10 Cognitive function;Information processing speed; LUSC cis rs4423214 0.840 rs1790344 chr11:71176897 A/G cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC cis rs9309473 0.950 rs1052162 chr2:73829372 A/G cg20560298 chr2:73613845 ALMS1 0.47 6.67 0.34 1.09e-10 Metabolite levels; LUSC cis rs6964587 1.000 rs9784993 chr7:91672403 G/A cg17063962 chr7:91808500 NA 0.58 9.29 0.45 2.01e-18 Breast cancer; LUSC cis rs921968 0.643 rs485765 chr2:219480804 C/G cg02176678 chr2:219576539 TTLL4 0.45 7.96 0.4 2.65e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs9902453 0.704 rs2628179 chr17:28071796 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.93 -0.44 2.92e-17 Coffee consumption (cups per day); LUSC cis rs7580658 0.929 rs4150477 chr2:128032546 A/G cg09760422 chr2:128146352 NA 0.3 6.56 0.34 2.05e-10 Protein C levels; LUSC trans rs8072100 0.935 rs12150231 chr17:45717091 G/A cg03886242 chr7:26192032 NFE2L3 0.38 6.36 0.33 6.45e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7512552 0.839 rs17597088 chr1:150475772 A/G cg15654264 chr1:150340011 RPRD2 0.64 10.58 0.5 9.39e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs10751667 0.600 rs14346 chr11:1011829 T/C cg06064525 chr11:970664 AP2A2 -0.29 -5.68 -0.3 2.94e-8 Alzheimer's disease (late onset); LUSC cis rs11958404 0.932 rs6859826 chr5:157429710 T/C cg05962755 chr5:157440814 NA 0.54 6.34 0.33 7.29e-10 IgG glycosylation; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg21782813 chr7:2030301 MAD1L1 0.53 9.11 0.45 7.8e-18 Bipolar disorder and schizophrenia; LUSC cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg18132916 chr6:79620363 NA -0.38 -5.69 -0.3 2.83e-8 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs3849570 0.643 rs10779987 chr3:81970856 C/T cg07356753 chr3:81810745 GBE1 -0.49 -7.22 -0.37 3.44e-12 Waist circumference;Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15583014 chr1:65468659 NA -0.4 -6.12 -0.32 2.57e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs57221529 0.766 rs72703075 chr5:592819 C/T cg17948913 chr5:572064 NA 0.4 5.92 0.31 7.86e-9 Lung disease severity in cystic fibrosis; LUSC cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs35146811 0.844 rs34031156 chr7:99677917 T/A cg13334819 chr7:99746414 C7orf59 -0.45 -6.13 -0.32 2.52e-9 Coronary artery disease; LUSC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg12403142 chr1:92012408 NA -0.38 -6.15 -0.32 2.25e-9 Breast cancer; LUSC cis rs1023500 0.506 rs6002625 chr22:42517689 A/G cg15557168 chr22:42548783 NA 0.42 6.33 0.33 8.02e-10 Schizophrenia; LUSC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.69 -11.55 -0.53 3.53e-26 Systemic lupus erythematosus; LUSC cis rs2073300 0.609 rs6137948 chr20:23416845 G/A cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1320333 0.772 rs2867136 chr2:701455 T/C cg27237671 chr2:676223 TMEM18 0.5 5.83 0.3 1.31e-8 Obesity-related traits; LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg02018176 chr4:1364513 KIAA1530 0.49 8.21 0.41 4.86e-15 Obesity-related traits; LUSC cis rs716595 0.867 rs12414179 chr10:111981935 C/A cg13996003 chr10:112034540 MXI1 -0.7 -5.81 -0.3 1.42e-8 Normalized brain volume; LUSC cis rs6456156 0.586 rs911632 chr6:167471461 T/C cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg22834771 chr12:69754056 YEATS4 -0.43 -6.03 -0.31 4.37e-9 Blood protein levels; LUSC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg03929089 chr4:120376271 NA -0.77 -12.23 -0.56 1.16e-28 Height; LUSC cis rs1215050 0.755 rs6843393 chr4:98822619 C/G cg05340658 chr4:99064831 C4orf37 0.43 6.75 0.35 6.4e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg06740227 chr12:86229804 RASSF9 -0.38 -6.11 -0.32 2.79e-9 Major depressive disorder; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.41 0.42 1.19e-15 Prudent dietary pattern; LUSC cis rs1784581 0.855 rs1790002 chr6:162384397 G/T cg17173639 chr6:162384350 PARK2 -0.84 -15.86 -0.66 1.31e-42 Itch intensity from mosquito bite; LUSC cis rs7584330 0.554 rs74449293 chr2:238426458 G/A cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.52 -0.46 3.68e-19 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs61931739 0.817 rs10772144 chr12:34242463 A/C cg24313572 chr1:56050060 NA -0.3 -6.26 -0.32 1.21e-9 Morning vs. evening chronotype; LUSC cis rs2996428 0.667 rs17412654 chr1:3758493 T/C cg22529645 chr1:3704559 LRRC47 0.37 6.22 0.32 1.46e-9 Red cell distribution width; LUSC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg06558623 chr16:89946397 TCF25 1.08 9.74 0.47 6.73e-20 Skin colour saturation; LUSC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg05368731 chr17:41323189 NBR1 0.78 12.93 0.58 2.86e-31 Menopause (age at onset); LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg11494091 chr17:61959527 GH2 0.63 13.54 0.6 1.31e-33 Prudent dietary pattern; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg20607798 chr8:58055168 NA 0.52 5.66 0.3 3.29e-8 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 12.22 0.56 1.23e-28 Personality dimensions; LUSC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg09323728 chr8:95962352 TP53INP1 -0.45 -9.18 -0.45 4.76e-18 Type 2 diabetes; LUSC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg14829155 chr15:31115871 NA -0.48 -6.86 -0.35 3.34e-11 Huntington's disease progression; LUSC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -5.99 -0.31 5.34e-9 Intelligence (multi-trait analysis); LUSC cis rs9747201 0.832 rs4072580 chr17:80160337 A/C cg18209359 chr17:80159595 CCDC57 -0.37 -6.33 -0.33 7.82e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg08975724 chr8:8085496 FLJ10661 0.61 9.17 0.45 4.84e-18 Neuroticism; LUSC cis rs34779708 0.966 rs1148245 chr10:35511894 C/T cg03585969 chr10:35415529 CREM 0.61 9.07 0.44 1.04e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11644478 chr21:40555479 PSMG1 0.94 18.71 0.72 5.98e-54 Cognitive function; LUSC cis rs8060686 0.641 rs73612690 chr16:68153200 G/A cg04539111 chr16:67997858 SLC12A4 -0.41 -5.66 -0.3 3.28e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03113475 chr19:12833063 TNPO2 0.47 7.53 0.38 4.75e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13012494 chr21:47604986 C21orf56 0.48 7.24 0.37 3.04e-12 Testicular germ cell tumor; LUSC cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg05738196 chr6:26577821 NA 0.76 13.81 0.6 1.24e-34 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg15790184 chr11:494944 RNH1 0.54 5.93 0.31 7.69e-9 Body mass index; LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg16362232 chr11:430036 ANO9 0.66 8.17 0.41 6.24e-15 Body mass index; LUSC cis rs12900413 0.562 rs12898229 chr15:90295960 C/T cg24249390 chr15:90295951 MESP1 -0.39 -6.25 -0.32 1.24e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg05025164 chr4:1340916 KIAA1530 0.42 6.43 0.33 4.51e-10 Obesity-related traits; LUSC cis rs7224314 1.000 rs7221926 chr17:65352181 A/T cg01507342 chr17:65387096 PITPNC1 -0.39 -6.88 -0.35 2.89e-11 Diisocyanate-induced asthma; LUSC cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.82 0.43 6.31e-17 Menopause (age at onset); LUSC cis rs8060686 0.516 rs12599238 chr16:68276235 G/A cg05110241 chr16:68378359 PRMT7 -0.69 -7.27 -0.37 2.54e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg01657329 chr11:68192670 LRP5 -0.46 -6.88 -0.35 2.94e-11 Total body bone mineral density; LUSC cis rs9325144 0.647 rs11169222 chr12:39105210 C/T cg13010199 chr12:38710504 ALG10B -0.51 -7.9 -0.4 4.04e-14 Morning vs. evening chronotype; LUSC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg11764359 chr7:65958608 NA 0.63 9.44 0.46 6.65e-19 Aortic root size; LUSC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg23262073 chr20:60523788 NA -0.43 -6.2 -0.32 1.69e-9 Body mass index; LUSC cis rs3755132 0.929 rs3755133 chr2:15731583 C/T cg12888861 chr2:15731646 DDX1 0.5 7.15 0.36 5.48e-12 Wilms tumor; LUSC cis rs6429082 0.702 rs2131922 chr1:235705001 G/T cg26050004 chr1:235667680 B3GALNT2 -0.46 -6.44 -0.33 4.23e-10 Adiposity; LUSC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg06481639 chr22:41940642 POLR3H 0.49 5.69 0.3 2.85e-8 Vitiligo; LUSC cis rs6496667 0.509 rs2657948 chr15:90948617 G/A cg22089800 chr15:90895588 ZNF774 0.53 7.63 0.39 2.43e-13 Rheumatoid arthritis; LUSC trans rs7681440 0.904 rs2301135 chr4:90758389 G/C cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.01 -0.31 4.73e-9 Dementia with Lewy bodies; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg22638593 chr5:131593259 PDLIM4 -0.39 -5.8 -0.3 1.56e-8 Breast cancer; LUSC cis rs7772486 0.875 rs2748497 chr6:146319417 C/T cg05347473 chr6:146136440 FBXO30 0.49 8.06 0.4 1.38e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs131777 0.575 rs963980 chr22:51022117 C/A cg25309564 chr22:51001381 C22orf41 0.44 6.23 0.32 1.38e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg11764359 chr7:65958608 NA -0.69 -10.67 -0.5 4.69e-23 Aortic root size; LUSC cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg08807101 chr21:30365312 RNF160 0.7 11.26 0.52 3.76e-25 Pancreatic cancer; LUSC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg11645453 chr3:52864694 ITIH4 0.31 6.86 0.35 3.32e-11 Electroencephalogram traits; LUSC cis rs2637266 1.000 rs10219023 chr10:78364537 G/A cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.97 -0.31 6.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7829975 0.606 rs10112585 chr8:8795030 A/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.57 -0.42 3.93e-16 Mood instability; LUSC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.74 0.3 2.15e-8 Intelligence (multi-trait analysis); LUSC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg03433033 chr1:76189801 ACADM -0.68 -9.21 -0.45 3.81e-18 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs11039798 0.588 rs11039782 chr11:48524785 A/G cg15704280 chr7:45808275 SEPT13 0.66 7.22 0.37 3.45e-12 Axial length; LUSC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg23283495 chr1:209979779 IRF6 0.66 7.9 0.4 4.2e-14 Coronary artery disease; LUSC trans rs3942852 0.868 rs7122335 chr11:48106486 C/T cg15704280 chr7:45808275 SEPT13 -0.53 -6.12 -0.32 2.64e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs4969178 0.965 rs8077859 chr17:76386335 C/T cg05887092 chr17:76393375 PGS1 0.53 9.35 0.46 1.28e-18 HDL cholesterol levels; LUSC cis rs34779708 0.966 rs4934536 chr10:35441169 A/G cg04310649 chr10:35416472 CREM -0.42 -6.59 -0.34 1.71e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg17294928 chr15:75287854 SCAMP5 -0.76 -10.12 -0.48 3.67e-21 Blood trace element (Zn levels); LUSC cis rs12530845 0.767 rs7784162 chr7:135305886 G/T cg23117316 chr7:135346802 PL-5283 -0.49 -8.65 -0.43 2.15e-16 Red blood cell traits; LUSC cis rs9420 0.961 rs7938083 chr11:57493622 C/A cg02958346 chr11:57425731 CLP1 -0.41 -5.75 -0.3 2.02e-8 Schizophrenia; LUSC cis rs2625529 0.730 rs1481861 chr15:72240129 A/G cg16672083 chr15:72433130 SENP8 0.5 7.99 0.4 2.24e-14 Red blood cell count; LUSC trans rs17685 0.753 rs1637051 chr7:75730659 G/A cg19862616 chr7:65841803 NCRNA00174 1.13 19.75 0.73 4.68e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs868036 0.609 rs3784707 chr15:68043878 A/C cg05925327 chr15:68127851 NA -0.46 -6.89 -0.35 2.81e-11 Restless legs syndrome; LUSC cis rs6722750 0.933 rs4671554 chr2:64411122 T/A cg22352474 chr2:64371530 PELI1 -0.52 -7.76 -0.39 1.06e-13 Neuroticism; LUSC cis rs6687430 0.526 rs12120962 chr1:10609505 G/A cg17425144 chr1:10567563 PEX14 0.63 12.44 0.56 1.95e-29 Hand grip strength; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg20295408 chr7:1910781 MAD1L1 0.52 7.56 0.38 3.91e-13 Bipolar disorder and schizophrenia; LUSC cis rs9527 0.590 rs7917650 chr10:104937100 G/C cg05855489 chr10:104503620 C10orf26 0.52 7.85 0.39 5.83e-14 Arsenic metabolism; LUSC cis rs1577917 0.958 rs36042496 chr6:86524214 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs2235649 0.746 rs35104579 chr16:1848657 A/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.11 -0.32 2.74e-9 Blood metabolite levels; LUSC cis rs10782582 0.609 rs1770889 chr1:76401166 A/G cg03433033 chr1:76189801 ACADM -0.39 -5.85 -0.3 1.19e-8 Daytime sleep phenotypes; LUSC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg15147215 chr3:52552868 STAB1 -0.32 -6.27 -0.32 1.14e-9 Bipolar disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04562739 chr20:5107446 CDS2;PCNA -0.45 -6.64 -0.34 1.29e-10 Electrocardiographic conduction measures; LUSC cis rs34779708 0.966 rs11599606 chr10:35406626 G/A cg04310649 chr10:35416472 CREM -0.43 -6.56 -0.34 2.05e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1595825 0.838 rs57437055 chr2:198782617 A/C cg00982548 chr2:198649783 BOLL -0.56 -7.04 -0.36 1.12e-11 Ulcerative colitis; LUSC trans rs953492 0.672 rs10926964 chr1:243359347 G/A cg01826367 chr1:224180288 NA -0.44 -6.46 -0.33 3.73e-10 Diastolic blood pressure; LUSC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg19717773 chr7:2847554 GNA12 -0.38 -6.1 -0.32 2.93e-9 Height; LUSC cis rs77633900 0.614 rs280029 chr15:77031235 A/G cg21673338 chr15:77095150 SCAPER -0.79 -7.72 -0.39 1.39e-13 Non-glioblastoma glioma;Glioma; LUSC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg03676636 chr4:99064102 C4orf37 0.36 7.85 0.39 5.64e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.62 0.38 2.6e-13 Bipolar disorder; LUSC cis rs977987 0.931 rs1424013 chr16:75495986 T/C cg03315344 chr16:75512273 CHST6 0.52 9.8 0.47 4.44e-20 Dupuytren's disease; LUSC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg03676636 chr4:99064102 C4orf37 0.37 7.65 0.39 2.14e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6984449 0.508 rs62496184 chr8:19319423 G/A cg01280390 chr8:19363452 CSGALNACT1 0.32 5.85 0.31 1.14e-8 Educational attainment; LUSC cis rs68170813 0.641 rs77397573 chr7:107006892 G/A cg02696742 chr7:106810147 HBP1 -0.63 -9.36 -0.46 1.24e-18 Coronary artery disease; LUSC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg08508325 chr11:3079039 CARS -0.51 -11.97 -0.55 1.02e-27 Longevity; LUSC cis rs9473147 0.516 rs9381575 chr6:47528764 C/G cg12968598 chr6:47444699 CD2AP 0.52 7.97 0.4 2.54e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7937682 0.921 rs11213945 chr11:111461003 A/G cg11344533 chr11:111475393 SIK2 0.45 5.89 0.31 9.38e-9 Primary sclerosing cholangitis; LUSC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg06287003 chr12:125626642 AACS -0.37 -6.48 -0.33 3.31e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg22549504 chr19:17448937 GTPBP3 0.53 6.68 0.34 1.01e-10 Systemic lupus erythematosus; LUSC cis rs7959452 0.570 rs10878964 chr12:69720691 T/G cg22834771 chr12:69754056 YEATS4 -0.45 -6.49 -0.33 3.14e-10 Blood protein levels; LUSC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg26597838 chr10:835615 NA 0.99 13.75 0.6 2.05e-34 Eosinophil percentage of granulocytes; LUSC cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.18 -0.45 4.78e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg16325326 chr1:53192061 ZYG11B 0.71 11.65 0.54 1.54e-26 Monocyte count; LUSC trans rs230489 0.668 rs1585606 chr4:103376409 G/A cg20368818 chr11:33800056 NA -0.44 -6.03 -0.31 4.25e-9 Intelligence (multi-trait analysis); LUSC cis rs56283067 0.547 rs12192267 chr6:45393787 C/T cg18551225 chr6:44695536 NA -0.4 -5.82 -0.3 1.41e-8 Total body bone mineral density; LUSC cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg04034577 chr2:241836375 C2orf54 -0.48 -8.93 -0.44 2.94e-17 Urinary metabolites; LUSC cis rs6430585 0.528 rs75753154 chr2:136665711 T/C cg07169764 chr2:136633963 MCM6 1.15 18.46 0.71 6.19e-53 Corneal structure; LUSC cis rs2948294 0.524 rs13270062 chr8:8112650 C/A cg15556689 chr8:8085844 FLJ10661 0.72 10.04 0.48 6.81e-21 Red cell distribution width; LUSC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.57e-10 Lung cancer; LUSC cis rs17407555 0.518 rs16891234 chr4:9946163 A/G cg11266682 chr4:10021025 SLC2A9 -0.44 -6.11 -0.32 2.75e-9 Schizophrenia (age at onset); LUSC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.77 0.35 5.69e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs3749237 1.000 rs4768 chr3:49758764 A/G cg21659725 chr3:3221576 CRBN 0.63 8.96 0.44 2.42e-17 Resting heart rate; LUSC cis rs3087591 0.919 rs2952983 chr17:29470288 G/C cg24425628 chr17:29625626 OMG;NF1 0.57 8.1 0.41 1.04e-14 Hip circumference; LUSC cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18676123 chr18:32870181 ZNF271;ZNF397OS -0.47 -6.82 -0.35 4.17e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17270561 0.666 rs12209856 chr6:25793673 G/A cg16482183 chr6:26056742 HIST1H1C 0.56 7.99 0.4 2.27e-14 Iron status biomarkers; LUSC cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg17845761 chr1:175162550 KIAA0040 -0.31 -5.91 -0.31 8.38e-9 Alcohol dependence; LUSC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg02475777 chr4:1388615 CRIPAK 0.42 6.22 0.32 1.49e-9 Obesity-related traits; LUSC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg11764359 chr7:65958608 NA 0.7 10.59 0.5 8.51e-23 Aortic root size; LUSC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg17366294 chr4:99064904 C4orf37 0.55 9.01 0.44 1.63e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs12476592 0.602 rs964880 chr2:63826932 C/A cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs9326248 0.581 rs11216242 chr11:116901549 G/A cg01368799 chr11:117014884 PAFAH1B2 0.61 9.46 0.46 5.81e-19 Blood protein levels; LUSC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4285028 0.948 rs10934565 chr3:121664661 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.78 -0.47 5.11e-20 Multiple sclerosis; LUSC cis rs713477 0.967 rs6573031 chr14:55913763 C/G cg13175173 chr14:55914753 NA -0.31 -6.49 -0.33 3.05e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC trans rs561341 0.941 rs2470236 chr17:30304940 G/C cg20587970 chr11:113659929 NA -1.12 -15.55 -0.65 2.16e-41 Hip circumference adjusted for BMI; LUSC cis rs7246967 0.551 rs3925175 chr19:22880958 G/A cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg01475377 chr6:109611718 NA -0.43 -7.78 -0.39 8.93e-14 Reticulocyte fraction of red cells; LUSC trans rs6502050 0.842 rs8080305 chr17:80074516 A/C cg07393940 chr7:158741817 NA -0.37 -6.61 -0.34 1.52e-10 Life satisfaction; LUSC cis rs868036 0.681 rs13329582 chr15:68104608 G/C cg08079166 chr15:68083412 MAP2K5 0.41 7.23 0.37 3.29e-12 Restless legs syndrome; LUSC cis rs1160297 0.643 rs6737483 chr2:53041627 G/A cg07782112 chr2:53107842 NA 0.39 6.13 0.32 2.47e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs8060686 0.516 rs7197756 chr16:68275516 A/C cg09835421 chr16:68378352 PRMT7 -0.48 -5.92 -0.31 7.94e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4243830 0.850 rs3761927 chr1:6601773 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -10.4 -0.49 3.84e-22 Body mass index; LUSC cis rs7267979 0.932 rs417130 chr20:25458320 T/C cg08601574 chr20:25228251 PYGB 0.42 6.35 0.33 7.01e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8133932 0.654 rs371587 chr21:47348512 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.8 -0.3 1.54e-8 Schizophrenia; LUSC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg10018233 chr7:150070692 REPIN1 0.4 6.66 0.34 1.16e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg21724239 chr8:58056113 NA 0.56 6.92 0.35 2.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg06873352 chr17:61820015 STRADA 0.71 12.79 0.57 9.37e-31 Prudent dietary pattern; LUSC cis rs2019216 0.500 rs2880292 chr17:21869537 A/G cg22648282 chr17:21454238 C17orf51 -0.54 -7.82 -0.39 6.97e-14 Pelvic organ prolapse; LUSC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.56 0.38 3.98e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2692947 0.526 rs58719199 chr2:96578247 G/A cg23100626 chr2:96804247 ASTL 0.3 7.07 0.36 9.39e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs78579285 0.584 rs9922996 chr16:88800670 G/C cg01900006 chr16:88814613 FAM38A 0.61 6.83 0.35 4.14e-11 Joint mobility (Beighton score); LUSC trans rs6502050 0.765 rs6502074 chr17:80121776 T/C cg07393940 chr7:158741817 NA 0.37 6.7 0.34 8.73e-11 Life satisfaction; LUSC cis rs2762353 0.935 rs1177442 chr6:25809069 A/G cg03517284 chr6:25882590 NA -0.43 -7.77 -0.39 9.83e-14 Blood metabolite levels; LUSC cis rs4076764 0.515 rs4657268 chr1:163376507 A/T cg24596788 chr1:163392923 NA -0.35 -6.06 -0.31 3.58e-9 Motion sickness; LUSC cis rs12188164 0.515 rs2672744 chr5:411047 A/G cg21972741 chr5:435613 AHRR -0.31 -5.81 -0.3 1.43e-8 Cystic fibrosis severity; LUSC cis rs7246657 0.943 rs35540940 chr19:38008235 G/A cg23950597 chr19:37808831 NA -0.6 -7.28 -0.37 2.42e-12 Coronary artery calcification; LUSC cis rs11585357 0.947 rs72646789 chr1:17610030 C/T cg08277548 chr1:17600880 PADI3 -0.65 -6.71 -0.34 8.54e-11 Hair shape; LUSC cis rs1775715 0.737 rs2778650 chr10:32106851 A/G cg26784012 chr10:32216390 ARHGAP12 0.44 7.39 0.37 1.21e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg08219700 chr8:58056026 NA 0.51 6.5 0.34 2.93e-10 Developmental language disorder (linguistic errors); LUSC cis rs894734 0.535 rs7301643 chr12:54325796 G/T cg25024717 chr12:54324583 NA -0.39 -6.71 -0.34 8.6e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs9326248 0.581 rs10892063 chr11:116896155 A/C cg01368799 chr11:117014884 PAFAH1B2 0.61 9.46 0.46 5.81e-19 Blood protein levels; LUSC cis rs2635047 0.935 rs2635050 chr18:44664131 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 7.16 0.36 5.04e-12 Educational attainment; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.12 -0.36 6.61e-12 Bipolar disorder; LUSC cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.39 6.03 0.31 4.32e-9 Multiple sclerosis; LUSC cis rs9879311 0.966 rs4684685 chr3:10411553 C/T cg08489410 chr3:10329245 GHRL;GHRLOS 0.43 6.99 0.36 1.5e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg25036284 chr2:26402008 FAM59B -0.73 -10.66 -0.5 4.85e-23 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.06e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs6951245 1.000 rs74366004 chr7:1088630 A/C cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg11247378 chr22:39784982 NA -0.66 -13.01 -0.58 1.35e-31 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.544 rs1124993 chr16:68114626 T/C cg27539214 chr16:67997921 SLC12A4 -0.55 -7.55 -0.38 4.15e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg00343986 chr7:65444356 GUSB 0.39 5.89 0.31 9.38e-9 Aortic root size; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg18718234 chr5:175874660 FAF2 0.54 6.79 0.35 5.2e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3916 0.955 rs34030695 chr12:121156496 G/A cg27246729 chr12:121163418 ACADS 0.49 7.15 0.36 5.49e-12 Urinary metabolites (H-NMR features); LUSC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg09835421 chr16:68378352 PRMT7 -0.56 -6.31 -0.33 8.67e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs4356932 1.000 rs6825045 chr4:76957558 C/T cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs2717559 0.542 rs2717560 chr8:143881670 G/A cg02415014 chr8:143852576 LYNX1 0.34 7.85 0.39 5.53e-14 Urinary tract infection frequency; LUSC cis rs7215564 0.908 rs34932625 chr17:78653155 A/G cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs61897795 0.657 rs174589 chr11:61615803 C/G cg21709803 chr11:61594965 FADS2 0.38 5.92 0.31 8.13e-9 Neutrophil count;Sum basophil neutrophil counts; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg08888203 chr3:10149979 C3orf24 0.64 9.15 0.45 5.82e-18 Alzheimer's disease; LUSC cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg01065977 chr19:18549689 ISYNA1 -0.23 -6.06 -0.31 3.73e-9 Breast cancer; LUSC cis rs1403694 0.695 rs11919484 chr3:186432839 G/T cg12454167 chr3:186435060 KNG1 0.34 8.4 0.42 1.26e-15 Blood protein levels; LUSC cis rs7659604 0.521 rs4833773 chr4:122689245 C/T cg19748678 chr4:122722346 EXOSC9 -0.48 -6.95 -0.36 1.9e-11 Type 2 diabetes; LUSC cis rs12586317 0.620 rs76293361 chr14:35570889 G/A cg16230307 chr14:35515116 FAM177A1 0.78 10.01 0.48 8.72e-21 Psoriasis; LUSC cis rs950027 0.620 rs1145076 chr15:45684508 G/T cg14582100 chr15:45693742 SPATA5L1 0.46 8.75 0.43 1.1e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -8.76 -0.43 1.01e-16 Bone mineral density; LUSC cis rs3126085 0.935 rs7534716 chr1:152198654 A/G cg26876637 chr1:152193138 HRNR 0.45 6.22 0.32 1.47e-9 Atopic dermatitis; LUSC trans rs2229238 0.911 rs58348886 chr1:154446198 T/C cg25273160 chr11:56955011 LRRC55 0.32 6.13 0.32 2.5e-9 Coronary heart disease; LUSC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg04398451 chr17:18023971 MYO15A -0.48 -7.72 -0.39 1.34e-13 Total body bone mineral density; LUSC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg03609598 chr5:56110824 MAP3K1 -0.41 -6.08 -0.32 3.34e-9 Initial pursuit acceleration; LUSC trans rs11723530 0.538 rs4692760 chr4:170813973 C/T cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.35 -0.33 7.2e-10 Myopia (pathological); LUSC trans rs4800353 0.929 rs4389219 chr18:19608334 A/G cg01841828 chr16:69166849 CHTF8;CIRH1A -0.58 -6.05 -0.31 3.85e-9 Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.42e-16 Menopause (age at onset); LUSC cis rs9494145 0.680 rs9376092 chr6:135427144 A/C cg22676075 chr6:135203613 NA -0.6 -8.54 -0.42 4.69e-16 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg17971929 chr21:40555470 PSMG1 0.81 14.23 0.61 3.06e-36 Cognitive function; LUSC cis rs7098414 0.511 rs10788603 chr10:82148137 G/T cg01528321 chr10:82214614 TSPAN14 0.61 8.9 0.44 3.61e-17 Post bronchodilator FEV1; LUSC cis rs11690935 0.838 rs10432423 chr2:172753295 G/A cg13550731 chr2:172543902 DYNC1I2 -0.81 -12.88 -0.58 4.33e-31 Schizophrenia; LUSC cis rs17401966 0.964 rs34215045 chr1:10361679 G/A cg19773385 chr1:10388646 KIF1B -0.54 -8.29 -0.41 2.84e-15 Hepatocellular carcinoma; LUSC cis rs2274273 1.000 rs7140872 chr14:55612744 C/T cg04306507 chr14:55594613 LGALS3 0.54 11.95 0.55 1.23e-27 Protein biomarker; LUSC trans rs6475216 0.900 rs1281350 chr9:18473576 C/G cg17555624 chr10:134053894 STK32C -0.31 -5.99 -0.31 5.32e-9 Obesity-related traits; LUSC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 8.25 0.41 3.68e-15 Personality dimensions; LUSC cis rs2832191 0.791 rs2251517 chr21:30531951 T/G cg24692254 chr21:30365293 RNF160 0.87 16.99 0.68 4.23e-47 Dental caries; LUSC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg05373962 chr22:49881684 NA -0.44 -10.5 -0.5 1.77e-22 Monocyte count;Monocyte percentage of white cells; LUSC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg08859206 chr1:53392774 SCP2 -0.49 -7.77 -0.39 9.48e-14 Monocyte count; LUSC cis rs6546537 0.503 rs6718872 chr2:69909977 A/C cg10773587 chr2:69614142 GFPT1 -0.42 -6.26 -0.32 1.16e-9 Serum thyroid-stimulating hormone levels; LUSC cis rs477895 1.000 rs2286614 chr11:64068310 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 6.97 0.36 1.66e-11 Mean platelet volume; LUSC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg19257562 chr1:2043853 PRKCZ 0.32 6.27 0.32 1.13e-9 Height; LUSC cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 7.1 0.36 7.63e-12 Platelet count; LUSC cis rs7769051 1.000 rs12203977 chr6:133122760 A/G cg22852734 chr6:133119734 C6orf192 1.17 14.03 0.61 1.8e-35 Type 2 diabetes nephropathy; LUSC cis rs9398803 0.865 rs4895808 chr6:126781434 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.9e-9 Male-pattern baldness; LUSC cis rs11051970 0.879 rs2467065 chr12:32586065 A/G cg02745156 chr12:32552066 NA 0.43 7.3 0.37 2.16e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6582630 0.555 rs61932279 chr12:38349096 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.48 -0.33 3.27e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6964587 1.000 rs6950470 chr7:91680641 G/A cg17063962 chr7:91808500 NA 0.57 9.05 0.44 1.24e-17 Breast cancer; LUSC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg16414030 chr3:133502952 NA -0.42 -6.47 -0.33 3.55e-10 Iron status biomarkers; LUSC cis rs2573652 0.722 rs8034841 chr15:100541593 G/T cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.92 -0.35 2.36e-11 Height; LUSC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg11247378 chr22:39784982 NA -0.64 -12.57 -0.57 6.06e-30 Intelligence (multi-trait analysis); LUSC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.5 -0.38 5.7e-13 Alzheimer's disease (late onset); LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.94 -0.31 7.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg01503450 chr10:980765 NA -0.39 -5.68 -0.3 2.88e-8 Eosinophil percentage of granulocytes; LUSC cis rs68170813 0.559 rs11773514 chr7:106958469 T/C cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.95 0.31 6.74e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg06740227 chr12:86229804 RASSF9 -0.46 -7.41 -0.38 1.02e-12 Major depressive disorder; LUSC cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg26384229 chr12:38710491 ALG10B 0.84 14.46 0.62 3.94e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs1034435 0.755 rs5767171 chr22:48891881 A/G cg05992904 chr22:48892994 FAM19A5 -0.41 -7.99 -0.4 2.22e-14 Late-onset Alzheimer's disease; LUSC cis rs6500395 0.926 rs11643272 chr16:48639723 T/C cg04672837 chr16:48644449 N4BP1 0.48 7.14 0.36 5.91e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2164273 0.565 rs2736387 chr8:11157371 A/C cg21775007 chr8:11205619 TDH 0.49 7.33 0.37 1.75e-12 Extraversion; LUSC trans rs459571 1.000 rs456207 chr9:136911140 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.41 -5.96 -0.31 6.29e-9 Platelet distribution width; LUSC cis rs56283067 0.847 rs12208621 chr6:44752003 G/C cg18551225 chr6:44695536 NA -0.49 -8.4 -0.42 1.32e-15 Total body bone mineral density; LUSC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg00857998 chr1:205179979 DSTYK 0.64 9.83 0.47 3.41e-20 Mean corpuscular volume;Mean platelet volume; LUSC trans rs7824557 0.751 rs2099456 chr8:11127001 A/C cg15556689 chr8:8085844 FLJ10661 0.54 8.71 0.43 1.42e-16 Retinal vascular caliber; LUSC cis rs1790761 0.658 rs666328 chr11:67335538 G/A cg00864171 chr11:67383662 NA 0.35 6.14 0.32 2.31e-9 Mean corpuscular volume; LUSC trans rs28647808 0.881 rs7852803 chr9:136245903 A/G cg12569217 chr2:109379859 RANBP2 0.61 5.98 0.31 5.69e-9 Blood protein levels; LUSC cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.5e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs6430585 0.528 rs309162 chr2:136690783 T/A cg07169764 chr2:136633963 MCM6 1.13 18.42 0.71 8.76e-53 Corneal structure; LUSC cis rs1971762 0.583 rs11170648 chr12:54089660 C/T cg23533419 chr12:54090519 NA -0.38 -6.23 -0.32 1.41e-9 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09192942 chr16:75682004 KARS;TERF2IP -0.47 -6.39 -0.33 5.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs2273669 0.667 rs2273668 chr6:109323519 G/T cg05315195 chr6:109294784 ARMC2 -0.56 -6.21 -0.32 1.54e-9 Prostate cancer; LUSC cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg04450456 chr4:17643702 FAM184B -0.36 -5.86 -0.31 1.11e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2637266 1.000 rs7080883 chr10:78361200 A/G cg18941641 chr10:78392320 NA 0.4 7.45 0.38 7.84e-13 Pulmonary function; LUSC cis rs6121246 0.909 rs6088962 chr20:30268184 C/T cg18721089 chr20:30220636 NA -0.35 -5.65 -0.3 3.36e-8 Mean corpuscular hemoglobin; LUSC cis rs3782089 0.793 rs34789990 chr11:65252477 G/T cg08676812 chr11:65308423 LTBP3 1.08 6.91 0.35 2.5e-11 Height; LUSC cis rs977987 0.736 rs4888392 chr16:75412262 T/C cg04384234 chr16:75411784 CFDP1 -0.44 -7.28 -0.37 2.4e-12 Dupuytren's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21306218 chr16:89787478 ZNF276;C16orf7 -0.56 -6.71 -0.34 8.11e-11 Bipolar disorder and schizophrenia; LUSC cis rs7560272 0.512 rs4530394 chr2:73929650 T/C cg20560298 chr2:73613845 ALMS1 0.39 5.9 0.31 8.71e-9 Schizophrenia; LUSC cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg18683606 chr7:100471612 SRRT 0.46 6.56 0.34 2.04e-10 Resting heart rate; LUSC cis rs6964587 0.869 rs401 chr7:91527945 T/G cg22709100 chr7:91322751 NA -0.4 -5.84 -0.3 1.21e-8 Breast cancer; LUSC cis rs922692 0.744 rs12899147 chr15:79079512 A/G cg00540400 chr15:79124168 NA -0.4 -7.02 -0.36 1.22e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2070488 0.699 rs13078966 chr3:38517914 T/G cg24069376 chr3:38537580 EXOG 0.41 7.95 0.4 2.89e-14 Electrocardiographic conduction measures; LUSC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg17724175 chr1:150552817 MCL1 0.36 6.5 0.34 2.95e-10 Tonsillectomy; LUSC cis rs7582180 0.585 rs12999151 chr2:100939333 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.35 -0.42 1.82e-15 Intelligence (multi-trait analysis); LUSC trans rs4650994 0.525 rs10913574 chr1:178536482 G/C cg05059571 chr16:84539110 KIAA1609 -0.47 -9.08 -0.44 9.83e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs1577917 0.958 rs4707236 chr6:86583967 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.35 -0.42 1.81e-15 Response to antipsychotic treatment; LUSC cis rs8179 0.645 rs42046 chr7:92252203 C/G cg15732164 chr7:92237376 CDK6 -0.43 -6.03 -0.31 4.45e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC trans rs12579753 0.957 rs35001833 chr12:82188510 C/G cg07923666 chr12:49932857 KCNH3 -0.52 -6.48 -0.33 3.31e-10 Resting heart rate; LUSC cis rs6088813 1.000 rs2248393 chr20:33926103 C/G cg14752227 chr20:34000481 UQCC 0.38 5.94 0.31 7.21e-9 Height; LUSC cis rs4253772 1.000 rs4253766 chr22:46623905 C/T cg18190219 chr22:46762943 CELSR1 -0.49 -6.16 -0.32 2.04e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs1521470 1.000 rs1521470 chr7:45646852 A/G cg26437564 chr7:45808727 SEPT13 -0.53 -5.92 -0.31 8.13e-9 Schizophrenia;Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.45 0.5 2.57e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs72781680 1.000 rs17712391 chr2:24245659 C/T cg20701182 chr2:24300061 SF3B14 0.77 7.83 0.39 6.56e-14 Lymphocyte counts; LUSC cis rs9815354 0.812 rs17215498 chr3:41829679 G/C cg03022575 chr3:42003672 ULK4 0.85 8.62 0.43 2.78e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 6.21 0.32 1.54e-9 Calcium levels; LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.53 -7.07 -0.36 9.06e-12 Renal function-related traits (BUN); LUSC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg25251562 chr2:3704773 ALLC -0.49 -7.44 -0.38 8.43e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg26338869 chr17:61819248 STRADA 0.41 5.9 0.31 8.95e-9 Prudent dietary pattern; LUSC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg18240062 chr17:79603768 NPLOC4 0.58 10.08 0.48 4.8e-21 Eye color traits; LUSC cis rs1865760 0.663 rs9467656 chr6:25993559 G/A cg16482183 chr6:26056742 HIST1H1C 0.47 6.97 0.36 1.75e-11 Height; LUSC cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.65 8.48 0.42 7.52e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg24531977 chr5:56204891 C5orf35 0.58 8.54 0.42 4.65e-16 Coronary artery disease; LUSC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg00933542 chr6:150070202 PCMT1 0.3 6.07 0.32 3.4e-9 Lung cancer; LUSC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg15839431 chr19:19639596 YJEFN3 -0.44 -6.19 -0.32 1.78e-9 Tonsillectomy; LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg04034577 chr2:241836375 C2orf54 0.5 9.41 0.46 8.46e-19 Urinary metabolites; LUSC cis rs2681472 0.524 rs7314459 chr12:89956341 T/A cg00757033 chr12:89920650 WDR51B 0.5 6.75 0.35 6.46e-11 Diastolic blood pressure;Coronary artery disease;Systolic blood pressure;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Hypertension; LUSC cis rs2760061 0.846 rs3094912 chr1:228209815 T/A cg01973587 chr1:228161476 NA -0.41 -7.23 -0.37 3.38e-12 Diastolic blood pressure; LUSC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.16 -0.32 2.06e-9 Total body bone mineral density; LUSC cis rs2806561 0.828 rs944509 chr1:23542242 C/T cg19743168 chr1:23544995 NA -0.46 -10.06 -0.48 5.5e-21 Height; LUSC trans rs6089829 0.962 rs4809462 chr20:61661560 A/G cg13615516 chr5:77269221 NA 0.41 6.9 0.35 2.64e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.14e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2348418 0.864 rs7312339 chr12:28711684 T/C cg13890972 chr12:28721907 NA -0.34 -5.92 -0.31 8.04e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18099408 chr3:52552593 STAB1 -0.4 -7.03 -0.36 1.19e-11 Electroencephalogram traits; LUSC cis rs2806561 0.715 rs10753550 chr1:23322471 C/G cg19743168 chr1:23544995 NA -0.38 -7.94 -0.4 3.11e-14 Height; LUSC cis rs881375 0.933 rs2239657 chr9:123671520 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.36 -5.8 -0.3 1.57e-8 Rheumatoid arthritis; LUSC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg22823121 chr1:150693482 HORMAD1 0.53 7.95 0.4 2.9e-14 Melanoma; LUSC cis rs73206853 0.841 rs6606683 chr12:110712212 T/G cg12870014 chr12:110450643 ANKRD13A 0.68 6.45 0.33 3.98e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7945718 0.967 rs10765990 chr11:12769444 G/A cg25843174 chr11:12811716 TEAD1 0.31 7.03 0.36 1.14e-11 Educational attainment (years of education); LUSC cis rs6754311 0.731 rs745500 chr2:136583192 G/A cg25344623 chr2:136566232 LCT 0.38 5.76 0.3 1.92e-8 Mosquito bite size; LUSC cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs2668423 0.922 rs3826942 chr19:1360575 A/G cg02639931 chr19:1387894 NDUFS7 0.5 8.49 0.42 6.69e-16 Nonalcoholic fatty liver disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07274506 chr1:6614341 TAS1R1;NOL9 -0.52 -6.15 -0.32 2.19e-9 Bipolar disorder and schizophrenia; LUSC cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg05855489 chr10:104503620 C10orf26 -0.59 -8.13 -0.41 8.58e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs733592 0.524 rs10875726 chr12:48425992 A/G cg24011408 chr12:48396354 COL2A1 -0.54 -8.92 -0.44 3.13e-17 Plateletcrit; LUSC cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.38 -5.83 -0.3 1.32e-8 IgG glycosylation; LUSC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg27286337 chr10:134555280 INPP5A 0.92 12.05 0.55 5.3e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs8114671 0.967 rs2093058 chr20:33791281 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -6.18 -0.32 1.84e-9 Height; LUSC trans rs617791 0.508 rs2276132 chr11:65770545 G/A cg17712092 chr4:129076599 LARP1B -0.69 -9.7 -0.47 8.89e-20 Breast cancer; LUSC trans rs7939886 0.920 rs17150102 chr11:55904382 A/C cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC trans rs2018683 0.624 rs6462119 chr7:29003725 G/C cg19402173 chr7:128379420 CALU -0.48 -7.29 -0.37 2.21e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs7584330 0.554 rs6740722 chr2:238393288 T/C cg14458575 chr2:238380390 NA 0.69 8.22 0.41 4.71e-15 Prostate cancer; LUSC cis rs9303401 0.632 rs7222087 chr17:57221619 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.45 6.75 0.35 6.54e-11 Cognitive test performance; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13938963 chr4:68411314 CENPC1 0.4 6.03 0.31 4.35e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg18402987 chr7:1209562 NA 0.73 7.92 0.4 3.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs62408225 1.000 rs62408236 chr6:90980148 C/T cg06866423 chr6:90926672 BACH2 0.41 5.92 0.31 7.99e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10121816 chr1:161123804 UFC1 -0.42 -6.16 -0.32 2.13e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9399135 0.967 rs1590975 chr6:135352088 C/T cg22676075 chr6:135203613 NA 0.47 7.64 0.39 2.28e-13 Red blood cell count; LUSC cis rs12464483 0.591 rs2602775 chr2:30883012 C/T cg07150166 chr2:30669952 LCLAT1 0.56 6.55 0.34 2.23e-10 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23452443 chr1:65210737 RAVER2 -0.5 -6.2 -0.32 1.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.59 -8.57 -0.42 3.79e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9916302 0.652 rs9903269 chr17:37742383 A/T cg07936489 chr17:37558343 FBXL20 -0.63 -7.52 -0.38 5.16e-13 Glomerular filtration rate (creatinine); LUSC cis rs2230307 0.536 rs684519 chr1:100604715 T/G cg24955406 chr1:100503596 HIAT1 -0.64 -6.87 -0.35 3.07e-11 Carotid intima media thickness; LUSC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs73206853 0.841 rs73191819 chr12:110920182 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg14820908 chr5:178986412 RUFY1 -0.63 -11.08 -0.52 1.7e-24 Lung cancer; LUSC trans rs7829975 0.606 rs891570 chr8:8794454 G/A cg21775007 chr8:11205619 TDH -0.41 -6.15 -0.32 2.16e-9 Mood instability; LUSC cis rs9611519 0.929 rs4821991 chr22:41440683 T/C cg13813247 chr22:41461852 NA -0.37 -6.75 -0.35 6.38e-11 Neuroticism; LUSC cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg26373071 chr5:1325741 CLPTM1L 0.44 8.18 0.41 5.88e-15 Lung cancer; LUSC cis rs8078723 0.546 rs8067817 chr17:38163936 C/T cg26162295 chr17:38119207 GSDMA -0.26 -6.07 -0.32 3.55e-9 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.3 0.41 2.67e-15 Prudent dietary pattern; LUSC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg11663144 chr21:46675770 NA -0.42 -7.34 -0.37 1.66e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15043801 chr19:10305911 DNMT1 0.4 6.09 0.32 3.11e-9 Triglycerides; LUSC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18005807 chr22:18506799 MICAL3 0.45 6.53 0.34 2.5e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs921968 0.643 rs520095 chr2:219329485 C/T cg02176678 chr2:219576539 TTLL4 0.6 10.75 0.51 2.5e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 14.48 0.62 3.25e-37 Platelet count; LUSC cis rs7927771 0.524 rs10838746 chr11:47706291 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.87e-10 Subjective well-being; LUSC cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg17420585 chr12:42539391 GXYLT1 -0.4 -8.07 -0.4 1.33e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.33 0.41 2.13e-15 Tonsillectomy; LUSC trans rs79976124 0.800 rs6918860 chr6:66637741 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 8.49 0.42 7.01e-16 Type 2 diabetes; LUSC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg03676636 chr4:99064102 C4orf37 0.33 6.97 0.36 1.68e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg00684032 chr4:1343700 KIAA1530 0.34 5.95 0.31 6.62e-9 Obesity-related traits; LUSC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg24399712 chr22:39784796 NA -0.62 -11.14 -0.52 1e-24 Intelligence (multi-trait analysis); LUSC cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC trans rs561341 0.941 rs2428336 chr17:30290577 T/C cg20587970 chr11:113659929 NA -1.16 -15.57 -0.65 1.7e-41 Hip circumference adjusted for BMI; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17468553 chr17:18086889 ALKBH5 0.76 6.15 0.32 2.25e-9 Cognitive performance; LUSC cis rs7772486 0.846 rs2492856 chr6:146323928 A/G cg05347473 chr6:146136440 FBXO30 0.5 8.29 0.41 2.83e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7264396 0.563 rs2425131 chr20:34337074 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.43 -0.42 1.01e-15 Total cholesterol levels; LUSC cis rs11190604 1.000 rs6584383 chr10:102303065 C/G cg16342193 chr10:102329863 NA -0.32 -5.71 -0.3 2.49e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1957429 0.614 rs117316280 chr14:65388641 T/C cg23373153 chr14:65346875 NA -0.98 -7.73 -0.39 1.3e-13 Pediatric areal bone mineral density (radius); LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg00149659 chr3:10157352 C3orf10 0.89 12.11 0.55 3.04e-28 Alzheimer's disease; LUSC cis rs2324229 0.828 rs1180239 chr6:83942604 G/A cg08257003 chr6:84140564 ME1 0.28 6.38 0.33 5.81e-10 Platelet-derived growth factor BB levels; LUSC cis rs6977660 0.660 rs28663574 chr7:19816905 G/A cg07541023 chr7:19748670 TWISTNB 0.63 6.84 0.35 3.87e-11 Thyroid stimulating hormone; LUSC cis rs1395 0.778 rs1439768 chr2:27389660 C/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.49 7.2 0.37 4.12e-12 Blood metabolite levels; LUSC cis rs7172677 0.768 rs2304901 chr15:75340722 G/A cg14664628 chr15:75095509 CSK 0.52 6.82 0.35 4.35e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs10464366 0.746 rs4723821 chr7:39141532 A/G cg10621924 chr7:39171070 POU6F2 0.43 6.41 0.33 5.06e-10 IgG glycosylation; LUSC cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg24642439 chr20:33292090 TP53INP2 0.47 7.2 0.37 3.89e-12 Glomerular filtration rate (creatinine); LUSC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg20701182 chr2:24300061 SF3B14 0.9 11.62 0.54 1.84e-26 Lymphocyte counts; LUSC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.24 0.41 3.84e-15 Hemoglobin concentration; LUSC cis rs7428496 0.528 rs11708470 chr3:142240824 A/G cg16271453 chr3:142027066 XRN1 -0.51 -8.91 -0.44 3.32e-17 Mean corpuscular hemoglobin; LUSC cis rs10743315 0.557 rs74669613 chr12:19313696 T/C cg02471346 chr12:19282374 PLEKHA5 0.75 6.24 0.32 1.35e-9 Gut microbiota (bacterial taxa); LUSC cis rs6066835 0.718 rs60028924 chr20:47359415 A/G cg18078177 chr20:47281410 PREX1 0.65 5.78 0.3 1.71e-8 Multiple myeloma; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg00684032 chr4:1343700 KIAA1530 0.34 6.13 0.32 2.5e-9 Obesity-related traits; LUSC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg06742321 chr12:123595122 PITPNM2 0.38 5.65 0.3 3.43e-8 Height;Educational attainment;Head circumference (infant); LUSC cis rs7072216 0.763 rs2147901 chr10:100165496 A/C cg26618903 chr10:100175079 PYROXD2 0.44 8.34 0.41 2.03e-15 Metabolite levels; LUSC cis rs7106204 0.534 rs78539127 chr11:24256698 T/A ch.11.24196551F chr11:24239977 NA 0.75 6.39 0.33 5.58e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2197308 0.765 rs2387436 chr12:37935337 C/T cg26384229 chr12:38710491 ALG10B -0.81 -13.47 -0.59 2.57e-33 Morning vs. evening chronotype; LUSC trans rs724744 0.772 rs1772075 chr6:22351325 G/T cg13807341 chr11:118445984 ARCN1 0.36 6.2 0.32 1.64e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs72634258 0.945 rs12757968 chr1:8106201 A/G cg26816564 chr1:7831052 VAMP3 0.5 5.97 0.31 6.12e-9 Inflammatory bowel disease; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2281558 0.876 rs2281562 chr20:25273362 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.63 9.57 0.46 2.5e-19 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC trans rs1864729 1.000 rs2635161 chr8:98282907 A/C cg08679828 chr8:102218111 ZNF706 0.84 7.78 0.39 9.33e-14 Estradiol plasma levels (breast cancer); LUSC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.22 -0.32 1.49e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11719291 0.915 rs9834996 chr3:48754877 G/T cg00383909 chr3:49044727 WDR6 1.14 10.59 0.5 8.4e-23 Cognitive function; LUSC cis rs7726839 0.540 rs7434 chr5:660804 A/G cg09021430 chr5:549028 NA 0.54 7.49 0.38 6.4e-13 Obesity-related traits; LUSC cis rs1348850 0.526 rs1345138 chr2:178387100 A/T cg22681709 chr2:178499509 PDE11A -0.45 -6.57 -0.34 1.91e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg13010199 chr12:38710504 ALG10B 0.66 10.21 0.49 1.83e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs12579753 0.917 rs7306043 chr12:82191282 G/A cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs3818285 0.655 rs623980 chr10:111646147 C/T cg00817464 chr10:111662876 XPNPEP1 -0.7 -12.7 -0.57 2.01e-30 Superior crus of antihelix expression; LUSC cis rs11633958 1 rs11633958 chr15:78862064 C/T cg18825076 chr15:78729989 IREB2 -0.5 -7.66 -0.39 2.01e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26258631 chr2:190648605 PMS1;ORMDL1 0.44 6.17 0.32 1.97e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg05872129 chr22:39784769 NA -0.59 -10.78 -0.51 1.82e-23 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg18681998 chr4:17616180 MED28 0.86 15.92 0.66 7.62e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7599312 0.534 rs6735626 chr2:213403972 G/A cg20637307 chr2:213403960 ERBB4 0.44 7.51 0.38 5.38e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1348850 0.914 rs4341974 chr2:178324879 A/C cg22681709 chr2:178499509 PDE11A -0.5 -9.31 -0.45 1.72e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9300255 0.602 rs1051431 chr12:123645803 G/A cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.12 -0.32 2.63e-9 Neutrophil percentage of white cells; LUSC cis rs778371 0.915 rs938569 chr2:233759695 C/G cg08000102 chr2:233561755 GIGYF2 0.72 9.49 0.46 4.62e-19 Schizophrenia; LUSC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg02772935 chr3:125709198 NA -0.48 -6.15 -0.32 2.17e-9 Blood pressure (smoking interaction); LUSC cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg06636001 chr8:8085503 FLJ10661 0.65 10.75 0.51 2.35e-23 Mood instability; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg11965913 chr1:205819406 PM20D1 0.89 18.27 0.71 3.38e-52 Menarche (age at onset); LUSC cis rs4499344 0.524 rs259242 chr19:33144248 A/C cg22980127 chr19:33182716 NUDT19 -0.42 -5.69 -0.3 2.77e-8 Mean platelet volume; LUSC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs9399401 0.710 rs10484733 chr6:142710988 C/G cg03128060 chr6:142623767 GPR126 0.61 9.98 0.48 1.1e-20 Chronic obstructive pulmonary disease; LUSC cis rs9929218 0.817 rs3114400 chr16:68719430 C/T cg02972257 chr16:68554789 NA 0.44 5.76 0.3 1.93e-8 Colorectal cancer; LUSC cis rs61931739 0.534 rs11053072 chr12:34202399 A/C cg06521331 chr12:34319734 NA -0.46 -7.55 -0.38 4.16e-13 Morning vs. evening chronotype; LUSC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg22467129 chr15:76604101 ETFA -0.46 -7.29 -0.37 2.21e-12 Blood metabolite levels; LUSC cis rs739401 0.595 rs402806 chr11:3066432 A/G cg25174290 chr11:3078921 CARS 0.62 9.88 0.48 2.32e-20 Longevity; LUSC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -6.34 -0.33 7.67e-10 Total body bone mineral density; LUSC cis rs4631830 0.683 rs10763193 chr10:51504938 G/A cg16070123 chr10:51489643 NA 0.55 9.19 0.45 4.36e-18 Prostate-specific antigen levels; LUSC cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg23649088 chr2:200775458 C2orf69 -0.47 -6.31 -0.33 8.98e-10 Schizophrenia; LUSC cis rs9653442 0.564 rs56054309 chr2:100794940 T/C cg22139774 chr2:100720529 AFF3 -0.4 -6.95 -0.36 1.96e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs1493916 0.837 rs1027332 chr18:31410097 A/C cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs6693567 0.545 rs6664703 chr1:150459087 G/C cg15654264 chr1:150340011 RPRD2 0.45 7.24 0.37 3.13e-12 Migraine; LUSC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg06634786 chr22:41940651 POLR3H -0.55 -6.39 -0.33 5.48e-10 Vitiligo; LUSC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg12639453 chr1:2035780 PRKCZ 0.3 6.31 0.33 9.02e-10 Height; LUSC cis rs694739 0.628 rs645078 chr11:64135298 A/C cg26898376 chr11:64110657 CCDC88B 0.32 5.93 0.31 7.66e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg13072238 chr3:49761600 GMPPB -0.67 -8.1 -0.41 1.01e-14 Menarche (age at onset); LUSC cis rs61931739 0.517 rs11053224 chr12:34484919 G/A cg06521331 chr12:34319734 NA -0.41 -6.5 -0.34 2.96e-10 Morning vs. evening chronotype; LUSC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg03806693 chr22:41940476 POLR3H 0.9 12.43 0.56 2.06e-29 Vitiligo; LUSC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.04 -0.31 4.17e-9 Developmental language disorder (linguistic errors); LUSC cis rs1595825 0.891 rs16826895 chr2:198901642 A/G cg00982548 chr2:198649783 BOLL -0.57 -7.09 -0.36 8.04e-12 Ulcerative colitis; LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg08859206 chr1:53392774 SCP2 0.5 8.51 0.42 6.03e-16 Monocyte count; LUSC cis rs2346177 0.519 rs2121698 chr2:46709571 C/T cg02822958 chr2:46747628 ATP6V1E2 0.47 8.3 0.41 2.68e-15 HDL cholesterol; LUSC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg24531977 chr5:56204891 C5orf35 0.45 6.7 0.34 9.09e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs1215050 0.776 rs1627946 chr4:98844416 G/A cg05340658 chr4:99064831 C4orf37 -0.44 -6.94 -0.36 2.02e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4363385 0.647 rs1995308 chr1:153014082 A/T cg00922841 chr1:152955080 SPRR1A -0.41 -6.75 -0.35 6.37e-11 Inflammatory skin disease; LUSC cis rs1950626 0.751 rs12883799 chr14:101396850 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.41 7.32 0.37 1.82e-12 Pelvic organ prolapse (moderate/severe); LUSC cis rs870825 0.616 rs1401362 chr4:185643775 G/A cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs559928 0.947 rs12417275 chr11:64143774 A/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 6.79 0.35 5.13e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4803468 1.000 rs2241711 chr19:41911980 T/C cg09537434 chr19:41945824 ATP5SL -0.89 -15.66 -0.65 7.53e-42 Height; LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg08200582 chr11:442649 ANO9 -0.55 -5.86 -0.31 1.13e-8 Body mass index; LUSC cis rs1801251 0.928 rs737028 chr2:233640750 T/C cg08000102 chr2:233561755 GIGYF2 0.7 11.54 0.53 3.86e-26 Coronary artery disease; LUSC cis rs10911232 0.507 rs10911194 chr1:182993025 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.78 0.51 1.95e-23 Hypertriglyceridemia; LUSC cis rs66887589 0.967 rs6844263 chr4:120433807 A/G cg24375607 chr4:120327624 NA 0.47 7.27 0.37 2.5e-12 Diastolic blood pressure; LUSC cis rs2463822 0.592 rs72919486 chr11:62043501 G/C cg06239285 chr11:62104954 ASRGL1 -0.75 -7.26 -0.37 2.74e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2721195 0.967 rs11777703 chr8:145703508 G/A cg15857475 chr8:145742913 RECQL4;LRRC14 -0.84 -15.09 -0.64 1.33e-39 Age at first birth; LUSC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg24399712 chr22:39784796 NA -0.65 -11.99 -0.55 8.41e-28 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs2258563 chr20:25273435 C/T cg08601574 chr20:25228251 PYGB 0.43 6.5 0.33 2.96e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg18681998 chr4:17616180 MED28 0.91 17.61 0.69 1.5e-49 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12579753 0.879 rs11615729 chr12:82128318 T/A cg21231944 chr12:82153410 PPFIA2 -0.4 -6.09 -0.32 3.1e-9 Resting heart rate; LUSC trans rs2739330 0.652 rs2000469 chr22:24245292 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.53 -7.76 -0.39 1.05e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.61 7.9 0.4 4.15e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs17253792 0.642 rs10483648 chr14:56104278 T/C cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.28e-10 Putamen volume; LUSC cis rs56804039 1.000 rs11777086 chr8:8384479 G/T cg15556689 chr8:8085844 FLJ10661 -0.58 -7.37 -0.37 1.39e-12 Cervical cancer; LUSC cis rs2404602 0.692 rs12911174 chr15:77149943 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.89 -0.35 2.85e-11 Blood metabolite levels; LUSC cis rs4388249 0.687 rs2301002 chr5:109101831 C/T cg17395555 chr5:108820864 NA 0.35 5.8 0.3 1.55e-8 Schizophrenia; LUSC cis rs2303759 0.914 rs2288481 chr19:49878196 G/A cg24324837 chr19:49891574 CCDC155 0.5 6.28 0.33 1.04e-9 Multiple sclerosis; LUSC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg03351412 chr1:154909251 PMVK -0.49 -7.48 -0.38 6.62e-13 Prostate cancer; LUSC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg16414030 chr3:133502952 NA -0.42 -6.52 -0.34 2.66e-10 Iron status biomarkers; LUSC cis rs7197653 0.748 rs11350 chr16:68335392 A/G cg05110241 chr16:68378359 PRMT7 -0.72 -8.1 -0.41 1.06e-14 Magnesium levels; LUSC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.738 rs34965784 chr4:120361586 G/C cg24375607 chr4:120327624 NA 0.79 11.79 0.54 4.81e-27 Corneal astigmatism; LUSC cis rs7937682 0.824 rs11213962 chr11:111506027 G/A cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg01652190 chr22:50026171 C22orf34 -0.29 -5.96 -0.31 6.24e-9 Monocyte count;Monocyte percentage of white cells; LUSC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg15704280 chr7:45808275 SEPT13 -1.09 -22.35 -0.77 2.54e-68 Height; LUSC cis rs4285028 0.747 rs77570895 chr3:121384565 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.89 -11.96 -0.55 1.1e-27 Multiple sclerosis; LUSC trans rs11992162 0.636 rs4841642 chr8:11798334 C/T cg06636001 chr8:8085503 FLJ10661 0.45 6.33 0.33 7.77e-10 Monocyte count; LUSC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg08470875 chr2:26401718 FAM59B -0.67 -8.96 -0.44 2.32e-17 Gut microbiome composition (summer); LUSC cis rs12594515 0.967 rs11854477 chr15:45998345 A/C cg06207120 chr15:45996521 NA 0.39 6.05 0.31 3.79e-9 Waist circumference;Weight; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg09509183 chr1:209979624 IRF6 0.63 11.03 0.52 2.51e-24 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg24060327 chr5:131705240 SLC22A5 0.66 10.19 0.49 2.09e-21 Breast cancer; LUSC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg06671706 chr8:8559999 CLDN23 0.48 6.41 0.33 5.01e-10 Obesity-related traits; LUSC cis rs8077889 0.917 rs72836547 chr17:41902799 G/T cg26893861 chr17:41843967 DUSP3 0.96 14.8 0.63 1.86e-38 Triglycerides; LUSC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.88 -0.51 8.12e-24 Schizophrenia; LUSC cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.71e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg11843238 chr5:131593191 PDLIM4 0.48 8.48 0.42 7.28e-16 Acylcarnitine levels; LUSC cis rs9467773 1.000 rs6933176 chr6:26540178 G/A cg09904177 chr6:26538194 HMGN4 0.75 14.27 0.62 2.07e-36 Intelligence (multi-trait analysis); LUSC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg12463550 chr7:65579703 CRCP 0.55 8.2 0.41 5.07e-15 Aortic root size; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02099313 chr1:231114956 TTC13;ARV1 0.41 6.07 0.32 3.51e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg06481639 chr22:41940642 POLR3H -0.5 -6.09 -0.32 3.05e-9 Vitiligo; LUSC cis rs17685 0.712 rs1859792 chr7:75789264 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.08 -0.4 1.21e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1451375 0.617 rs12671474 chr7:50591395 C/A cg18232548 chr7:50535776 DDC 0.54 7.58 0.38 3.41e-13 Malaria; LUSC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg09365446 chr1:150670422 GOLPH3L 0.5 7.27 0.37 2.54e-12 Melanoma; LUSC cis rs1045714 0.895 rs1107690 chr7:2640595 G/T cg24848437 chr7:2645542 IQCE 0.63 6.91 0.35 2.49e-11 Urate levels in lean individuals; LUSC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg12615879 chr12:58013172 SLC26A10 0.26 5.65 0.3 3.37e-8 Multiple sclerosis; LUSC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg22166914 chr1:53195759 ZYG11B 0.64 11.08 0.52 1.66e-24 Monocyte count; LUSC cis rs9325144 0.560 rs7980358 chr12:38640396 C/G cg13010199 chr12:38710504 ALG10B 0.52 7.67 0.39 1.96e-13 Morning vs. evening chronotype; LUSC cis rs4631830 0.812 rs11593361 chr10:51539156 A/G cg20129853 chr10:51489980 NA -0.33 -6.72 -0.35 7.85e-11 Prostate-specific antigen levels; LUSC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC trans rs1945213 0.694 rs34390414 chr11:55863367 T/G cg03929089 chr4:120376271 NA 0.68 7.63 0.39 2.56e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg12016809 chr21:47604291 C21orf56 0.46 7.0 0.36 1.38e-11 Testicular germ cell tumor; LUSC cis rs752092 0.894 rs8036083 chr15:101767822 T/G cg19997662 chr15:101784653 CHSY1 -0.37 -5.73 -0.3 2.2e-8 Corneal structure; LUSC cis rs1670533 1.000 rs34956924 chr4:1047270 T/C cg02018176 chr4:1364513 KIAA1530 0.48 6.15 0.32 2.16e-9 Recombination rate (females); LUSC cis rs9303401 0.659 rs62081314 chr17:56778328 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.26 0.59 1.63e-32 Cognitive test performance; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg26774385 chr6:35354049 PPARD -0.34 -5.99 -0.31 5.3300000000000004e-09 Mosquito bite size; LUSC cis rs2439831 1.000 rs2254321 chr15:43707542 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.27 0.52 3.4e-25 Lung cancer in ever smokers; LUSC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg04414720 chr1:150670196 GOLPH3L 0.51 8.09 0.4 1.11e-14 Melanoma; LUSC cis rs16854884 0.837 rs4380409 chr3:143800896 A/G cg06585982 chr3:143692056 C3orf58 0.44 6.51 0.34 2.69e-10 Economic and political preferences (feminism/equality); LUSC trans rs2736340 0.539 rs11250138 chr8:11323312 C/G cg15556689 chr8:8085844 FLJ10661 -0.48 -6.71 -0.34 8.4e-11 Systemic lupus erythematosus and Systemic sclerosis;Rheumatoid arthritis;Systemic lupus erythematosus;Kawasaki disease;Systemic lupus erythematosus or rheumatoid arthritis; LUSC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg16262614 chr3:133464971 TF 0.43 7.48 0.38 6.56e-13 Iron status biomarkers (transferrin levels); LUSC trans rs9860340 0.730 rs57541218 chr3:87643230 T/G cg03644585 chr7:884825 UNC84A 0.42 6.05 0.31 3.9e-9 Electroencephalographic traits in alcoholism; LUSC trans rs236907 0.859 rs56377810 chr1:171757657 A/C cg13482142 chr2:234261155 NA 0.5 6.03 0.31 4.37e-9 Mean platelet volume; LUSC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg05738196 chr6:26577821 NA 0.53 8.33 0.41 2.14e-15 Schizophrenia; LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg22963979 chr7:1858916 MAD1L1 -0.63 -10.07 -0.48 5.35e-21 Bipolar disorder and schizophrenia; LUSC cis rs59918340 0.936 rs6982449 chr8:142234642 T/C cg23750338 chr8:142222470 SLC45A4 -0.44 -8.01 -0.4 1.97e-14 Immature fraction of reticulocytes; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg10802521 chr3:52805072 NEK4 0.47 7.77 0.39 9.61e-14 Electroencephalogram traits; LUSC cis rs16854884 0.558 rs6768153 chr3:143667429 C/A cg06585982 chr3:143692056 C3orf58 0.51 7.97 0.4 2.56e-14 Economic and political preferences (feminism/equality); LUSC cis rs4363385 0.818 rs946096 chr1:153006529 T/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs17824933 1.000 rs12791045 chr11:60767964 C/T cg16817237 chr11:60793675 NA 0.41 6.58 0.34 1.79e-10 Multiple sclerosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08151832 chr16:66835414 CCDC79 0.48 6.06 0.31 3.62e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg25036284 chr2:26402008 FAM59B -0.73 -10.67 -0.5 4.57e-23 Gut microbiome composition (summer); LUSC cis rs1182196 0.533 rs2527521 chr7:2904928 A/G cg19717773 chr7:2847554 GNA12 0.32 5.91 0.31 8.54e-9 Plateletcrit; LUSC cis rs6681460 0.966 rs4655650 chr1:67142286 A/G cg02459107 chr1:67143332 SGIP1 0.48 9.19 0.45 4.14e-18 Presence of antiphospholipid antibodies; LUSC cis rs6063312 0.935 rs6095256 chr20:47340806 C/T cg18078177 chr20:47281410 PREX1 0.62 7.3 0.37 2.09e-12 Tonometry; LUSC cis rs2070433 0.948 rs2839304 chr21:47952650 C/G cg12379764 chr21:47803548 PCNT -0.73 -9.64 -0.47 1.43e-19 Lymphocyte counts; LUSC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg03806693 chr22:41940476 POLR3H 0.89 12.29 0.56 6.63e-29 Vitiligo; LUSC cis rs9348739 1 rs9348739 chr6:26923099 G/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.46 -5.69 -0.3 2.75e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.32 0.49 7.54e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -7.02 -0.36 1.26e-11 Mean platelet volume; LUSC cis rs2230307 0.656 rs644835 chr1:100543962 A/G cg24955406 chr1:100503596 HIAT1 0.66 6.33 0.33 8.05e-10 Carotid intima media thickness; LUSC cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg25208724 chr1:156163844 SLC25A44 1.04 18.13 0.7 1.3e-51 Testicular germ cell tumor; LUSC cis rs9322817 0.691 rs6929352 chr6:105204621 T/C cg02098413 chr6:105308735 HACE1 -0.28 -5.81 -0.3 1.48e-8 Thyroid stimulating hormone; LUSC cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.31e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs55665837 1.000 rs10832257 chr11:14443316 A/G cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs7954584 0.546 rs10840630 chr12:122352445 C/T cg10207240 chr12:122356781 WDR66 0.46 6.41 0.33 4.92e-10 Mean corpuscular volume; LUSC trans rs7819412 0.715 rs2409727 chr8:11043236 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.14 -0.41 7.96e-15 Triglycerides; LUSC cis rs9905704 0.645 rs831952 chr17:56669583 T/C cg12560992 chr17:57184187 TRIM37 0.51 5.96 0.31 6.45e-9 Testicular germ cell tumor; LUSC cis rs11168618 0.810 rs11168595 chr12:48868211 C/T cg24011408 chr12:48396354 COL2A1 0.38 6.06 0.31 3.62e-9 Adiponectin levels; LUSC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.92e-12 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.930 rs2277915 chr2:15493881 A/G cg19274914 chr2:15703543 NA 0.44 8.18 0.41 5.97e-15 Educational attainment (years of education); LUSC cis rs5758511 0.689 rs5758691 chr22:42668504 G/C cg00645731 chr22:42541494 CYP2D7P1 0.57 10.11 0.48 3.77e-21 Birth weight; LUSC cis rs7605827 0.897 rs12692274 chr2:15707711 A/G cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.64e-17 Educational attainment (years of education); LUSC cis rs6598163 0.564 rs12319878 chr12:132289989 C/T cg22244940 chr12:132335942 MMP17 0.54 8.11 0.41 1e-14 Migraine; LUSC cis rs11229555 0.645 rs72917641 chr11:58227320 A/C cg15696309 chr11:58395628 NA -0.68 -8.26 -0.41 3.34e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg07936489 chr17:37558343 FBXL20 0.71 9.96 0.48 1.21e-20 Glomerular filtration rate (creatinine); LUSC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.79 -10.13 -0.48 3.29e-21 Schizophrenia; LUSC cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg03717367 chr9:139980219 LOC100289341;MAN1B1 0.61 10.7 0.51 3.55e-23 Cerebrospinal fluid biomarker levels; LUSC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg24549020 chr5:56110836 MAP3K1 -0.44 -5.8 -0.3 1.57e-8 Initial pursuit acceleration; LUSC cis rs7923609 0.902 rs10822182 chr10:65325478 G/A cg01631684 chr10:65280961 REEP3 -0.42 -6.59 -0.34 1.76e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs2130392 0.926 rs1107907 chr4:185620108 G/T cg04058563 chr4:185651563 MLF1IP 0.46 7.51 0.38 5.55e-13 Kawasaki disease; LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg16606324 chr3:10149918 C3orf24 0.63 8.77 0.43 8.98e-17 Alzheimer's disease; LUSC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg15921436 chr17:44337874 NA 0.72 10.94 0.51 5.21e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs11252926 0.563 rs10904173 chr10:462885 G/A cg18196295 chr10:418757 DIP2C -0.51 -8.28 -0.41 3.05e-15 Psychosis in Alzheimer's disease; LUSC cis rs9815354 0.680 rs73073250 chr3:42016559 G/T cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg25072359 chr17:41440525 NA -0.58 -8.34 -0.41 2.03e-15 Menopause (age at onset); LUSC cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg06636001 chr8:8085503 FLJ10661 0.53 8.58 0.42 3.64e-16 Mood instability; LUSC trans rs6952808 0.594 rs3778964 chr7:2138109 C/T cg04565464 chr8:145669602 NFKBIL2 0.37 5.98 0.31 5.67e-9 Bipolar disorder and schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06866400 chr6:143771904 ADAT2;PEX3 -0.5 -6.62 -0.34 1.4e-10 Bipolar disorder and schizophrenia; LUSC cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg11266682 chr4:10021025 SLC2A9 0.49 9.11 0.45 8.01e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9926296 0.715 rs2115401 chr16:89740609 A/G cg01097406 chr16:89675127 NA -0.39 -7.85 -0.39 5.86e-14 Vitiligo; LUSC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg15320075 chr8:145703422 NA -0.51 -8.55 -0.42 4.64e-16 Age at first birth; LUSC cis rs778371 0.723 rs12999865 chr2:233627250 T/C cg08000102 chr2:233561755 GIGYF2 0.82 14.01 0.61 2.03e-35 Schizophrenia; LUSC cis rs11711311 1.000 rs12632983 chr3:113481913 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.92 0.35 2.34e-11 IgG glycosylation; LUSC cis rs11166629 1.000 rs1545240 chr8:135642632 A/C cg27224718 chr8:135614730 ZFAT 0.65 10.82 0.51 1.35e-23 Smoking quantity; LUSC cis rs113835537 0.935 rs117131621 chr11:66422334 C/T cg24851651 chr11:66362959 CCS 0.53 6.54 0.34 2.38e-10 Airway imaging phenotypes; LUSC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg11366901 chr6:160182831 ACAT2 0.93 12.87 0.58 4.58e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs8077889 1.000 rs8077889 chr17:41878166 G/T cg26893861 chr17:41843967 DUSP3 -0.89 -13.02 -0.58 1.3e-31 Triglycerides; LUSC cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg13319975 chr6:146136371 FBXO30 0.49 7.4 0.38 1.08e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.56 0.42 4.17e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg16325326 chr1:53192061 ZYG11B 0.97 18.7 0.72 6.96e-54 Monocyte count; LUSC cis rs6964587 0.869 rs406 chr7:91546526 C/A cg17063962 chr7:91808500 NA -0.53 -8.1 -0.41 1.01e-14 Breast cancer; LUSC trans rs7939886 0.841 rs79254833 chr11:55986896 T/C cg15704280 chr7:45808275 SEPT13 0.9 6.77 0.35 5.92e-11 Myopia (pathological); LUSC cis rs8028313 0.731 rs11857017 chr15:67972908 A/G cg05925327 chr15:68127851 NA -0.39 -6.1 -0.32 2.89e-9 Obesity; LUSC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg26695010 chr11:65641043 EFEMP2 -0.46 -7.05 -0.36 1.01e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg03233332 chr7:66118400 NA -0.4 -5.94 -0.31 7.06e-9 Aortic root size; LUSC cis rs1949733 0.585 rs2631768 chr4:8473050 A/G cg13073564 chr4:8508604 NA 0.37 6.89 0.35 2.77e-11 Response to antineoplastic agents; LUSC cis rs2204008 0.837 rs1842599 chr12:37986081 G/A cg26384229 chr12:38710491 ALG10B -0.81 -13.37 -0.59 6.09e-33 Bladder cancer; LUSC cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg06060754 chr5:176797920 RGS14 0.57 8.97 0.44 2.24e-17 Hemoglobin concentration;Hematocrit; LUSC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs7267979 0.844 rs8184820 chr20:25250577 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -13.09 -0.58 6.88e-32 Liver enzyme levels (alkaline phosphatase); LUSC trans rs1973993 0.967 rs10875017 chr1:96949526 C/T cg10631902 chr5:14652156 NA 0.53 8.97 0.44 2.13e-17 Weight; LUSC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg18230493 chr5:56204884 C5orf35 -0.57 -9.01 -0.44 1.62e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg13560548 chr3:10150139 C3orf24 0.49 6.59 0.34 1.76e-10 Alzheimer's disease; LUSC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.78 -0.3 1.68e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.13 -0.32 2.43e-9 IgG glycosylation; LUSC cis rs34638657 0.702 rs12599988 chr16:82200063 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.55e-10 Lung adenocarcinoma; LUSC cis rs7917772 0.582 rs12782153 chr10:104368294 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.67 -10.95 -0.51 4.72e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7560272 0.695 rs13022149 chr2:73641515 T/A cg20560298 chr2:73613845 ALMS1 0.48 7.48 0.38 6.66e-13 Schizophrenia; LUSC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg11062466 chr8:58055876 NA 0.5 6.32 0.33 8.39e-10 Developmental language disorder (linguistic errors); LUSC cis rs6500395 0.926 rs2883643 chr16:48693018 C/G cg04672837 chr16:48644449 N4BP1 0.44 6.43 0.33 4.38e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12421382 0.636 rs1439519 chr11:109378438 A/G cg27471124 chr11:109292789 C11orf87 0.4 7.01 0.36 1.36e-11 Schizophrenia; LUSC cis rs1865760 0.865 rs9467647 chr6:25957642 A/G cg16482183 chr6:26056742 HIST1H1C 0.47 6.93 0.35 2.2e-11 Height; LUSC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.2 0.64 5.07e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2414856 0.510 rs72758911 chr15:64641404 A/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.73 0.54 7.46e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1891275 0.515 rs1986941 chr10:93444343 C/T cg07889827 chr10:93443413 NA -0.38 -8.55 -0.42 4.34e-16 Intelligence (multi-trait analysis); LUSC cis rs78366141 0.536 rs76432068 chr4:89624219 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.97 7.26 0.37 2.73e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2730245 0.592 rs2657385 chr7:158649373 A/G cg24397884 chr7:158709396 WDR60 0.6 9.23 0.45 3.26e-18 Height; LUSC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg00933542 chr6:150070202 PCMT1 -0.31 -6.3 -0.33 9.53e-10 Lung cancer; LUSC cis rs1008375 0.932 rs9291660 chr4:17663414 A/G cg18681998 chr4:17616180 MED28 0.89 15.6 0.65 1.34e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg01879757 chr17:41196368 BRCA1 0.48 7.84 0.39 6.27e-14 Menopause (age at onset); LUSC cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.18 0.45 4.56e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg23711669 chr6:146136114 FBXO30 -0.92 -18.15 -0.7 1.08e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg11494091 chr17:61959527 GH2 0.65 13.87 0.6 7.1e-35 Prudent dietary pattern; LUSC cis rs7927771 0.524 rs754434 chr11:47814280 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.51 0.34 2.74e-10 Subjective well-being; LUSC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg20302533 chr7:39170763 POU6F2 0.55 9.09 0.45 8.94e-18 IgG glycosylation; LUSC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg12615879 chr12:58013172 SLC26A10 -0.27 -5.71 -0.3 2.48e-8 Multiple sclerosis; LUSC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.65 9.87 0.48 2.53e-20 Height; LUSC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg12350822 chr6:88032061 C6orf162;GJB7 0.64 13.18 0.58 3.09e-32 Monocyte percentage of white cells; LUSC cis rs66887589 0.775 rs6843229 chr4:120424087 T/C cg24375607 chr4:120327624 NA 0.51 7.93 0.4 3.28e-14 Diastolic blood pressure; LUSC cis rs12928939 0.815 rs12446005 chr16:71655035 G/A cg03805757 chr16:71968109 PKD1L3 -0.42 -6.0 -0.31 5.05e-9 Post bronchodilator FEV1; LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg12564285 chr5:131593104 PDLIM4 0.44 7.82 0.39 7.21e-14 Breast cancer; LUSC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg05340658 chr4:99064831 C4orf37 0.63 9.93 0.48 1.53e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg11764359 chr7:65958608 NA -0.71 -11.03 -0.52 2.54e-24 Aortic root size; LUSC cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg21770322 chr7:97807741 LMTK2 0.5 8.59 0.43 3.5e-16 Breast cancer; LUSC cis rs11711311 0.955 rs9830102 chr3:113408302 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 6.0 0.31 5.19e-9 IgG glycosylation; LUSC cis rs12210905 0.925 rs72838258 chr6:27007681 G/A cg23155468 chr6:27110703 HIST1H2BK -0.65 -5.68 -0.3 2.93e-8 Hip circumference adjusted for BMI; LUSC cis rs6500395 1.000 rs4785536 chr16:48712980 C/T cg04672837 chr16:48644449 N4BP1 -0.47 -7.06 -0.36 9.68e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9888739 1.000 rs73534420 chr16:31311374 G/T cg15817542 chr16:31343056 ITGAM -0.5 -6.1 -0.32 2.98e-9 Systemic lupus erythematosus; LUSC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg03806693 chr22:41940476 POLR3H 0.98 14.31 0.62 1.46e-36 Vitiligo; LUSC cis rs2115536 0.640 rs934134 chr15:80168218 T/C cg02196730 chr15:80188777 MTHFS 0.39 5.82 0.3 1.38e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9653442 0.564 rs2309756 chr2:100780269 G/C cg07810366 chr2:100720526 AFF3 -0.44 -7.49 -0.38 6.12e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7020830 0.928 rs11544336 chr9:37089150 A/G cg14294708 chr9:37120828 ZCCHC7 1.1 25.3 0.81 1.31e-79 Schizophrenia; LUSC cis rs77633900 0.614 rs280005 chr15:77009185 G/C cg21673338 chr15:77095150 SCAPER -0.81 -8.34 -0.42 2e-15 Non-glioblastoma glioma;Glioma; LUSC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg27539214 chr16:67997921 SLC12A4 -0.59 -7.75 -0.39 1.11e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs12190007 0.547 rs3006217 chr6:169862878 A/G cg15038512 chr6:170123185 PHF10 -0.4 -6.55 -0.34 2.15e-10 Obesity-related traits; LUSC cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg12219531 chr12:120966889 COQ5 0.61 8.09 0.4 1.1e-14 High light scatter reticulocyte count; LUSC cis rs7829975 0.567 rs6601273 chr8:8796519 T/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.96 -0.48 1.26e-20 Mood instability; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19451435 chr6:158402916 SYNJ2 -0.48 -5.96 -0.31 6.25e-9 Bipolar disorder and schizophrenia; LUSC cis rs2011503 0.882 rs4808933 chr19:19363812 T/A cg11584989 chr19:19387371 SF4 0.61 7.27 0.37 2.54e-12 Bipolar disorder; LUSC cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg05347473 chr6:146136440 FBXO30 0.53 9.11 0.45 7.97e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs7726839 0.540 rs72705097 chr5:655067 G/A cg25482853 chr8:67687455 SGK3 1.09 15.45 0.65 5.28e-41 Obesity-related traits; LUSC cis rs637571 0.584 rs7107912 chr11:65603252 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.52 -6.95 -0.36 1.89e-11 Eosinophil percentage of white cells; LUSC cis rs7607369 0.782 rs514799 chr2:219411203 A/G cg02176678 chr2:219576539 TTLL4 0.74 14.55 0.62 1.7e-37 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs8072100 0.967 rs4794001 chr17:45720849 T/C cg25173405 chr17:45401733 C17orf57 -0.37 -5.97 -0.31 6.19e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2607426 1.000 rs2607425 chr19:41274885 C/G cg05508168 chr19:41255947 C19orf54;SNRPA -0.65 -6.14 -0.32 2.34e-9 Blood protein levels; LUSC cis rs7107174 1.000 rs2511166 chr11:77964331 T/C cg02023728 chr11:77925099 USP35 0.45 6.83 0.35 3.93e-11 Testicular germ cell tumor; LUSC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 1.9e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs7786877 0.583 rs41303510 chr7:100226129 C/T cg06565620 chr18:47792949 CCDC11 0.53 5.97 0.31 6.1e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.41 -0.33 4.94e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs208520 0.608 rs3846803 chr6:66805743 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.53 -0.69 3.06e-49 Exhaled nitric oxide output; LUSC cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.28 0.37 2.4e-12 Cognitive ability; LUSC cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg07148914 chr20:33460835 GGT7 -0.47 -6.95 -0.36 1.94e-11 Height; LUSC cis rs11122272 0.735 rs2256908 chr1:231506557 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.78 -0.47 4.83e-20 Hemoglobin concentration; LUSC trans rs11098499 0.722 rs1814814 chr4:120258124 C/G cg25214090 chr10:38739885 LOC399744 0.47 7.55 0.38 4.07e-13 Corneal astigmatism; LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg13010199 chr12:38710504 ALG10B 0.65 9.81 0.47 3.95e-20 Bladder cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12465643 chr17:71640353 SDK2 0.44 6.23 0.32 1.42e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6960043 0.905 rs10264723 chr7:15054370 T/C cg19272540 chr7:15055459 NA 0.35 8.9 0.44 3.51e-17 Type 2 diabetes; LUSC cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg00046913 chr16:1877150 HAGH;FAHD1 0.5 5.74 0.3 2.15e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7267979 1.000 rs4813563 chr20:25365340 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.75 -0.73 4.73e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2522056 0.932 rs2522064 chr5:131806488 G/A cg24060327 chr5:131705240 SLC22A5 0.42 5.85 0.3 1.2e-8 Lymphocyte counts;Fibrinogen; LUSC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg01849466 chr14:104193079 ZFYVE21 0.58 9.04 0.44 1.29e-17 Schizophrenia; LUSC cis rs1801251 0.963 rs13011298 chr2:233612996 A/G cg08000102 chr2:233561755 GIGYF2 0.68 11.29 0.53 2.97e-25 Coronary artery disease; LUSC cis rs10740039 0.516 rs1009410 chr10:62354797 T/G cg18175470 chr10:62150864 ANK3 -0.47 -7.01 -0.36 1.33e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2880765 0.835 rs4843063 chr15:86048748 G/T cg13263323 chr15:86062960 AKAP13 -0.36 -5.88 -0.31 9.92e-9 Coronary artery disease; LUSC cis rs925255 0.810 rs7574996 chr2:28643523 G/C cg01273330 chr2:28605224 NA -0.41 -6.64 -0.34 1.29e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg00049323 chr5:472564 LOC25845 -0.4 -5.98 -0.31 5.77e-9 Cystic fibrosis severity; LUSC trans rs4332037 0.851 rs1403175 chr7:1964357 A/T cg10840412 chr1:235813424 GNG4 -0.69 -9.3 -0.45 1.86e-18 Bipolar disorder; LUSC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg21963583 chr11:68658836 MRPL21 0.55 8.28 0.41 3.08e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2050392 0.965 rs1543725 chr10:30698873 A/G cg18806716 chr10:30721971 MAP3K8 -0.45 -7.49 -0.38 6.05e-13 Inflammatory bowel disease; LUSC cis rs4692589 0.606 rs34752946 chr4:170951738 G/T cg19918862 chr4:170955249 NA 0.36 6.07 0.32 3.52e-9 Anxiety disorder; LUSC cis rs9399401 0.961 rs1342060 chr6:142663177 T/C cg03128060 chr6:142623767 GPR126 0.31 5.65 0.3 3.37e-8 Chronic obstructive pulmonary disease; LUSC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg19230755 chr7:65878503 NA 0.41 5.75 0.3 2.01e-8 Aortic root size; LUSC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs17739794 0.517 rs35856917 chr8:774395 C/G cg01971667 chr8:817044 NA -0.4 -6.31 -0.33 8.78e-10 Clozapine-induced cytotoxicity; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg18147569 chr3:113871615 DRD3 0.4 6.09 0.32 3.06e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01745629 chr6:83775548 UBE2CBP 0.76 6.04 0.31 4.17e-9 Cognitive performance; LUSC cis rs9549367 0.707 rs9549353 chr13:113843427 G/A cg00898013 chr13:113819073 PROZ -0.63 -8.86 -0.44 4.89e-17 Platelet distribution width; LUSC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg15534755 chr11:117069859 TAGLN -0.36 -6.16 -0.32 2.04e-9 Blood protein levels; LUSC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg06494592 chr3:125709126 NA -0.5 -5.7 -0.3 2.59e-8 Blood pressure (smoking interaction); LUSC cis rs7607369 0.536 rs12694443 chr2:219664977 G/T cg02176678 chr2:219576539 TTLL4 -0.51 -8.94 -0.44 2.63e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7903847 0.642 rs7084654 chr10:99135262 G/A cg06359132 chr10:99160096 RRP12 -0.24 -5.65 -0.3 3.39e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg18681998 chr4:17616180 MED28 0.84 15.29 0.64 2.27e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4631830 0.869 rs11006207 chr10:51538176 T/C cg10326726 chr10:51549505 MSMB -0.36 -6.16 -0.32 2.08e-9 Prostate-specific antigen levels; LUSC cis rs6121246 0.567 rs6120815 chr20:30184866 T/C cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg00599273 chr12:58146742 CDK4 0.31 5.81 0.3 1.48e-8 Multiple sclerosis; LUSC cis rs587080 0.559 rs12364730 chr11:65228278 C/T cg17120908 chr11:65337727 SSSCA1 -0.65 -9.5 -0.46 4.3e-19 Plateletcrit; LUSC cis rs1018836 0.599 rs9643295 chr8:91492283 T/G cg16814680 chr8:91681699 NA -0.62 -9.2 -0.45 4.07e-18 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4792901 0.802 rs9908559 chr17:41603161 T/C cg22562494 chr17:41607896 ETV4 -0.33 -6.07 -0.32 3.49e-9 Dupuytren's disease; LUSC cis rs7106204 0.514 rs12282611 chr11:24271352 A/C ch.11.24196551F chr11:24239977 NA 0.84 8.15 0.41 7.36e-15 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg03354898 chr7:1950403 MAD1L1 -0.34 -6.59 -0.34 1.73e-10 Bipolar disorder and schizophrenia; LUSC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg06238570 chr21:40685208 BRWD1 0.58 9.1 0.45 8.66e-18 Menarche (age at onset); LUSC cis rs6456156 0.792 rs4710183 chr6:167514083 A/G cg07741184 chr6:167504864 NA -0.35 -6.09 -0.32 3.14e-9 Primary biliary cholangitis; LUSC cis rs5753037 0.803 rs131263 chr22:30133045 C/T cg11564601 chr22:30592435 NA 0.34 6.05 0.31 3.86e-9 Type 1 diabetes; LUSC trans rs6981523 0.500 rs4412337 chr8:11072020 C/T cg15556689 chr8:8085844 FLJ10661 0.51 7.37 0.37 1.36e-12 Neuroticism; LUSC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg20283391 chr11:68216788 NA 0.53 8.02 0.4 1.77e-14 Total body bone mineral density; LUSC cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.21 0.56 1.32e-28 Colorectal cancer; LUSC cis rs62400317 0.762 rs12193264 chr6:44930793 T/C cg20913747 chr6:44695427 NA -0.46 -7.27 -0.37 2.59e-12 Total body bone mineral density; LUSC cis rs4660306 1.000 rs6429567 chr1:45956700 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.15 -0.36 5.48e-12 Homocysteine levels; LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg20706599 chr15:90777202 CIB1;C15orf58 0.67 6.02 0.31 4.63e-9 Body mass index; LUSC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg25554036 chr4:6271136 WFS1 0.61 12.6 0.57 4.94e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7100689 0.622 rs1340383 chr10:82095968 T/G cg01528321 chr10:82214614 TSPAN14 0.83 12.43 0.56 2.11e-29 Post bronchodilator FEV1; LUSC cis rs3806843 0.576 rs155359 chr5:140315425 G/T cg19875535 chr5:140030758 IK 0.4 6.1 0.32 2.93e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs870825 0.587 rs28454955 chr4:185632701 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.33 0.59 8.18e-33 Blood protein levels; LUSC trans rs7824557 0.591 rs2736282 chr8:11225480 C/T cg08975724 chr8:8085496 FLJ10661 0.43 6.29 0.33 9.76e-10 Retinal vascular caliber; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05463257 chr3:182782445 MCCC1 0.46 6.04 0.31 4.12e-9 Bipolar disorder and schizophrenia; LUSC cis rs73001065 0.636 rs8182472 chr19:19539891 A/G cg03709012 chr19:19516395 GATAD2A 0.88 8.38 0.42 1.46e-15 LDL cholesterol; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10014674 chr1:33430585 RNF19B 0.42 6.3 0.33 9.32e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg05246507 chr14:21493295 NDRG2 0.44 6.37 0.33 6.27e-10 Mosquito bite size; LUSC cis rs9914988 1.000 rs9895443 chr17:27182944 A/G cg07195577 chr17:27052828 TLCD1 0.44 5.71 0.3 2.54e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs8060686 0.545 rs75229939 chr16:68164949 G/A cg27539214 chr16:67997921 SLC12A4 -0.6 -7.17 -0.37 4.72e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg04248312 chr19:17393744 ANKLE1 -1.03 -16.87 -0.68 1.27e-46 Systemic lupus erythematosus; LUSC cis rs6494488 0.500 rs72742982 chr15:64977055 C/T cg08069370 chr15:64387884 SNX1 -0.68 -5.9 -0.31 8.97e-9 Coronary artery disease; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18404041 chr3:52824283 ITIH1 0.55 11.01 0.52 3.03e-24 Bipolar disorder; LUSC cis rs7267979 1.000 rs6083825 chr20:25366424 T/C cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9902453 0.967 rs9900911 chr17:28330280 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.79 -0.43 8.13e-17 Coffee consumption (cups per day); LUSC trans rs4718428 0.705 rs2901311 chr7:66415069 T/C cg18876405 chr7:65276391 NA 0.49 6.52 0.34 2.54e-10 Corneal structure; LUSC cis rs2290159 0.752 rs3773349 chr3:12649732 T/C cg23032965 chr3:12705835 RAF1 0.74 8.96 0.44 2.42e-17 Cholesterol, total; LUSC cis rs9393777 0.778 rs35526527 chr6:27042287 C/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.5 -5.87 -0.31 1.06e-8 Intelligence (multi-trait analysis); LUSC cis rs9462027 0.651 rs2395599 chr6:34641415 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.16 -0.32 2.13e-9 Systemic lupus erythematosus; LUSC cis rs7615316 0.751 rs2862745 chr3:142071932 A/G cg16271453 chr3:142027066 XRN1 -0.41 -7.1 -0.36 7.66e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs73206853 0.841 rs4131850 chr12:110812553 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs61931739 0.749 rs11053093 chr12:34231095 A/G cg06521331 chr12:34319734 NA -0.37 -6.38 -0.33 5.81e-10 Morning vs. evening chronotype; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15543754 chr2:54950739 EML6 0.42 6.38 0.33 5.8e-10 Triglycerides; LUSC cis rs4253772 0.872 rs14843 chr22:46639462 A/T cg18190219 chr22:46762943 CELSR1 -0.52 -6.02 -0.31 4.71e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg02018176 chr4:1364513 KIAA1530 0.49 7.71 0.39 1.42e-13 Obesity-related traits; LUSC cis rs12368653 0.616 rs1027315 chr12:58034192 T/C cg18357645 chr12:58087776 OS9 0.39 5.85 0.3 1.16e-8 Multiple sclerosis; LUSC cis rs936229 0.768 rs12442901 chr15:75083912 A/G cg10253484 chr15:75165896 SCAMP2 -0.52 -6.79 -0.35 5.27e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs3960554 1.000 rs2079477 chr7:75836549 C/G cg19862616 chr7:65841803 NCRNA00174 0.87 10.06 0.48 5.91e-21 Eotaxin levels; LUSC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg16060761 chr17:80687452 NA 0.42 6.44 0.33 4.23e-10 Breast cancer; LUSC cis rs6494488 0.500 rs78659827 chr15:64721927 G/T cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Coronary artery disease; LUSC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11890956 chr21:40555474 PSMG1 -0.86 -15.4 -0.64 8.61e-41 Cognitive function; LUSC cis rs4077515 0.504 rs7628 chr9:139318071 A/G cg14169450 chr9:139327907 INPP5E 0.43 7.43 0.38 9.25e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg08470875 chr2:26401718 FAM59B -0.68 -9.2 -0.45 4.11e-18 Gut microbiome composition (summer); LUSC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg21862992 chr11:68658383 NA 0.51 7.93 0.4 3.29e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7607369 0.719 rs690882 chr2:219640620 T/C cg02176678 chr2:219576539 TTLL4 -0.54 -9.53 -0.46 3.28e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs12776158 0.901 rs59262400 chr10:71216310 G/A cg12610070 chr10:71211762 TSPAN15 -0.46 -6.05 -0.31 3.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11758351 1.000 rs112751982 chr6:26191958 C/T cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.09e-12 Mean platelet volume; LUSC cis rs2274273 0.870 rs7153612 chr14:55788762 T/C cg04306507 chr14:55594613 LGALS3 0.54 11.81 0.54 3.97e-27 Protein biomarker; LUSC trans rs7980799 0.653 rs1384598 chr12:33622899 T/A cg13010199 chr12:38710504 ALG10B -0.43 -6.35 -0.33 7.23e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs8060686 0.516 rs8062085 chr16:68289313 C/A cg05110241 chr16:68378359 PRMT7 -0.53 -6.53 -0.34 2.4e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg17420585 chr12:42539391 GXYLT1 -0.36 -7.14 -0.36 5.99e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs897984 0.646 rs9938088 chr16:30830004 G/A cg02466173 chr16:30829666 NA -0.68 -15.99 -0.66 3.82e-43 Dementia with Lewy bodies; LUSC cis rs2115630 1.000 rs4633690 chr15:85361960 C/T cg09876464 chr15:85330779 ZNF592 0.37 6.93 0.35 2.11e-11 P wave terminal force; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -5.79 -0.3 1.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs4285028 0.699 rs73855465 chr3:121574219 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.79 -10.65 -0.5 5.28e-23 Multiple sclerosis; LUSC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 12.23 0.56 1.09e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9309473 0.950 rs10198549 chr2:73794404 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.48 -0.33 3.37e-10 Metabolite levels; LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 13.27 0.59 1.5e-32 Alzheimer's disease; LUSC cis rs7131987 0.650 rs11050188 chr12:29473108 A/C cg09582351 chr12:29534625 ERGIC2 -0.34 -6.81 -0.35 4.53e-11 QT interval; LUSC cis rs11758351 0.587 rs2050950 chr6:26234883 A/G cg01420254 chr6:26195488 NA 0.65 7.24 0.37 3.03e-12 Gout;Renal underexcretion gout; LUSC cis rs11252926 0.673 rs816620 chr10:645916 A/G cg18196295 chr10:418757 DIP2C -0.41 -6.16 -0.32 2.06e-9 Psychosis in Alzheimer's disease; LUSC cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg11244672 chr19:19639970 YJEFN3 -0.61 -7.57 -0.38 3.66e-13 Bipolar disorder; LUSC cis rs698813 0.703 rs2053457 chr2:44572164 C/T cg00619915 chr2:44497795 NA -0.39 -5.72 -0.3 2.4e-8 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs941408 0.515 rs4624312 chr19:2774460 T/C cg19676328 chr12:49525230 TUBA1B -0.51 -7.38 -0.37 1.27e-12 Total cholesterol levels; LUSC cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg16339924 chr4:17578868 LAP3 -0.54 -8.22 -0.41 4.53e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg04317338 chr11:64019027 PLCB3 0.67 7.69 0.39 1.71e-13 Mean platelet volume; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg16145915 chr7:1198662 ZFAND2A -0.54 -10.0 -0.48 8.76e-21 Longevity;Endometriosis; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg02018176 chr4:1364513 KIAA1530 -0.56 -9.75 -0.47 6.08e-20 Obesity-related traits; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg02675527 chr2:114030824 PAX8;LOC440839 0.49 7.03 0.36 1.2e-11 Renal function-related traits (BUN); LUSC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg17385448 chr1:15911702 AGMAT 0.36 6.17 0.32 1.97e-9 Systolic blood pressure; LUSC trans rs1728785 0.901 rs1631910 chr16:68603335 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs2898681 0.561 rs6855240 chr4:53740787 G/A cg00791764 chr4:53727839 RASL11B 0.48 6.39 0.33 5.59e-10 Optic nerve measurement (cup area); LUSC cis rs1018836 0.923 rs13259842 chr8:91550819 A/G cg16814680 chr8:91681699 NA -0.77 -13.25 -0.59 1.69e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7223966 1.000 rs72848797 chr17:61934664 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.47 0.33 3.52e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6459788 0.585 rs6950818 chr7:157235364 C/G cg06271696 chr7:157225062 NA -0.48 -9.91 -0.48 1.9e-20 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs9549367 0.713 rs9549682 chr13:113830181 C/T cg00898013 chr13:113819073 PROZ -0.65 -8.98 -0.44 2e-17 Platelet distribution width; LUSC cis rs12519773 0.550 rs4242242 chr5:92519387 G/A cg18783429 chr5:92414398 NA 0.32 6.8 0.35 4.87e-11 Migraine; LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg13047869 chr3:10149882 C3orf24 0.64 9.04 0.44 1.29e-17 Alzheimer's disease; LUSC cis rs7107174 1.000 rs7116698 chr11:77995191 T/C cg02023728 chr11:77925099 USP35 0.49 7.06 0.36 9.61e-12 Testicular germ cell tumor; LUSC cis rs4343996 0.603 rs4722722 chr7:3398176 T/A cg21248987 chr7:3385318 SDK1 -0.35 -5.85 -0.3 1.17e-8 Motion sickness; LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg05552183 chr6:42928497 GNMT 0.49 8.17 0.41 6.42e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.7 -0.34 8.78e-11 Total body bone mineral density; LUSC cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.96 13.78 0.6 1.66e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7264396 0.887 rs224354 chr20:34054609 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.66 -0.34 1.1e-10 Total cholesterol levels; LUSC cis rs72960926 0.744 rs72964259 chr6:74882885 A/T cg03266952 chr6:74778945 NA -0.8 -6.35 -0.33 7.23e-10 Metabolite levels (MHPG); LUSC cis rs977987 0.806 rs12449170 chr16:75463012 C/T cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs6690583 0.623 rs1371140 chr1:85455362 A/C cg22153463 chr1:85462885 MCOLN2 0.61 5.91 0.31 8.56e-9 Serum sulfate level; LUSC cis rs2692947 0.644 rs1724125 chr2:96831355 G/A cg23100626 chr2:96804247 ASTL 0.3 6.99 0.36 1.5e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10791097 0.720 rs6590516 chr11:130733393 G/T cg12179176 chr11:130786555 SNX19 0.75 11.85 0.54 2.82e-27 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC cis rs11123610 0.679 rs34705357 chr2:3716032 C/T cg10645314 chr2:3704589 ALLC -0.44 -7.14 -0.36 5.82e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2235573 0.551 rs139893 chr22:38393608 G/A cg06521852 chr22:38141419 TRIOBP -0.35 -5.74 -0.3 2.1e-8 Glioblastoma;Glioma; LUSC cis rs2204008 0.594 rs11531211 chr12:37998007 T/G cg13010199 chr12:38710504 ALG10B -0.62 -9.56 -0.46 2.65e-19 Bladder cancer; LUSC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg12292205 chr6:26970375 C6orf41 -0.7 -12.21 -0.56 1.3e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs778371 0.958 rs778341 chr2:233728801 C/A cg08000102 chr2:233561755 GIGYF2 -0.74 -10.35 -0.49 6.08e-22 Schizophrenia; LUSC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg21970626 chr13:21893289 NA -0.51 -9.73 -0.47 7.04e-20 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7617480 0.648 rs4974088 chr3:48898749 T/C cg07636037 chr3:49044803 WDR6 0.9 11.71 0.54 9.27e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08672557 chr10:22292767 DNAJC1 0.5 6.96 0.36 1.85e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs722599 0.847 rs2058919 chr14:75310812 C/G cg08847533 chr14:75593920 NEK9 -0.41 -6.07 -0.32 3.52e-9 IgG glycosylation; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg22907277 chr7:1156413 C7orf50 0.6 9.33 0.45 1.56e-18 Longevity;Endometriosis; LUSC cis rs62400317 0.859 rs6919998 chr6:45159289 C/T cg20913747 chr6:44695427 NA -0.48 -7.67 -0.39 1.91e-13 Total body bone mineral density; LUSC cis rs1434579 0.526 rs204547 chr19:44947184 T/C cg15540054 chr19:45004280 ZNF180 -0.46 -6.55 -0.34 2.15e-10 Tuberculosis; LUSC cis rs11608355 0.515 rs7976796 chr12:109928013 C/T cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs4285028 0.699 rs2689285 chr3:121586486 G/A cg11130432 chr3:121712080 ILDR1 0.6 9.25 0.45 2.71e-18 Multiple sclerosis; LUSC cis rs12493885 0.769 rs61791509 chr3:153753178 T/C cg17054900 chr3:154042577 DHX36 -0.67 -7.06 -0.36 9.76e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.31 -5.75 -0.3 2.07e-8 Intelligence (multi-trait analysis); LUSC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg03477792 chr4:77819574 ANKRD56 0.61 8.59 0.43 3.44e-16 Emphysema distribution in smoking; LUSC trans rs12310956 0.510 rs11052882 chr12:33890017 T/C cg26384229 chr12:38710491 ALG10B 0.55 8.59 0.43 3.34e-16 Morning vs. evening chronotype; LUSC cis rs13064411 0.696 rs6783965 chr3:113198722 C/T cg18753928 chr3:113234510 CCDC52 -0.53 -8.13 -0.41 8.46e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC trans rs1874124 0.577 rs2807880 chr1:221043003 A/G cg00338749 chr11:1036677 MUC6 -0.39 -6.09 -0.32 3.16e-9 Cholesterol, total; LUSC cis rs422249 0.512 rs174574 chr11:61600342 A/C cg19610905 chr11:61596333 FADS2 0.53 8.11 0.41 9.83e-15 Trans fatty acid levels; LUSC cis rs1448094 0.872 rs1026085 chr12:86355735 A/G cg18827107 chr12:86230957 RASSF9 -0.39 -5.81 -0.3 1.45e-8 Major depressive disorder; LUSC cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg06784218 chr1:46089804 CCDC17 0.49 9.61 0.47 1.83e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4356932 0.691 rs9995007 chr4:76897791 T/A cg00809888 chr4:76862425 NAAA 0.37 5.91 0.31 8.4e-9 Blood protein levels; LUSC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg14552801 chr7:65878734 NA -0.46 -6.54 -0.34 2.37e-10 Aortic root size; LUSC cis rs4077515 0.934 rs78428995 chr9:139281847 T/C cg14019695 chr9:139328340 INPP5E 0.43 7.92 0.4 3.67e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2274273 0.588 rs9323285 chr14:55863829 A/C cg04306507 chr14:55594613 LGALS3 -0.47 -9.19 -0.45 4.3e-18 Protein biomarker; LUSC trans rs2262909 0.925 rs404822 chr19:22215967 A/C cg05197062 chr11:11642011 GALNTL4 -0.52 -7.13 -0.36 6.21e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs713477 0.618 rs6573033 chr14:55919060 C/G cg13175173 chr14:55914753 NA -0.3 -6.27 -0.32 1.14e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs8141529 0.632 rs5762803 chr22:29193638 G/C cg02153584 chr22:29168773 CCDC117 0.56 8.51 0.42 5.78e-16 Lymphocyte counts; LUSC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg12257692 chr3:49977190 RBM6 0.24 6.57 0.34 1.89e-10 Intelligence (multi-trait analysis); LUSC cis rs829883 0.659 rs4762495 chr12:98934105 C/T cg25150519 chr12:98850993 NA -0.63 -8.71 -0.43 1.47e-16 Colorectal adenoma (advanced); LUSC cis rs41271473 1.000 rs55956922 chr1:228872549 T/A cg16512390 chr1:228756714 NA 0.5 6.01 0.31 4.98e-9 Chronic lymphocytic leukemia; LUSC cis rs12681287 0.547 rs13267858 chr8:87510871 G/A cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs7577696 0.524 rs12991444 chr2:32265125 G/T cg02381751 chr2:32503542 YIPF4 -0.45 -5.99 -0.31 5.32e-9 Inflammatory biomarkers; LUSC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -7.93 -0.4 3.41e-14 Tuberculosis; LUSC cis rs12681288 0.523 rs73176528 chr8:961962 G/A cg15309053 chr8:964076 NA 0.4 7.97 0.4 2.55e-14 Schizophrenia; LUSC cis rs2481665 0.510 rs2481676 chr1:62627675 C/T cg18591186 chr1:62594603 INADL -0.45 -7.61 -0.38 2.86e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg18477163 chr1:228402036 OBSCN -0.56 -10.37 -0.49 5.11e-22 Diastolic blood pressure; LUSC cis rs7428 0.545 rs4832163 chr2:85541083 T/C cg24342717 chr2:85555507 TGOLN2 -0.74 -11.95 -0.55 1.24e-27 Ear protrusion; LUSC cis rs11711311 1.000 rs12637066 chr3:113527574 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.89 0.35 2.87e-11 IgG glycosylation; LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg04944784 chr2:26401820 FAM59B -0.75 -10.76 -0.51 2.13e-23 Gut microbiome composition (summer); LUSC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.69e-9 Aortic root size; LUSC cis rs6494488 0.500 rs72742989 chr15:64994464 A/G cg08069370 chr15:64387884 SNX1 -0.68 -5.9 -0.31 8.97e-9 Coronary artery disease; LUSC cis rs887829 0.570 rs10175809 chr2:234596865 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.28 -0.33 1.04e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs1044573 0.514 rs2268879 chr20:25177805 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.46 -7.87 -0.4 5.04e-14 Allergic rhinitis; LUSC cis rs62400317 0.859 rs12212745 chr6:45166258 C/T cg18551225 chr6:44695536 NA -0.43 -6.97 -0.36 1.73e-11 Total body bone mineral density; LUSC cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg17366294 chr4:99064904 C4orf37 0.56 7.82 0.39 6.99e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6599077 1.000 rs9853406 chr3:40097964 T/C cg13683864 chr3:40499215 RPL14 -0.61 -7.25 -0.37 2.94e-12 Sleep-related phenotypes; LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg25288140 chr17:41278341 BRCA1;NBR2 -0.38 -5.73 -0.3 2.28e-8 Menopause (age at onset); LUSC cis rs11190604 1.000 rs10883506 chr10:102289743 C/G cg23241863 chr10:102295624 HIF1AN 0.48 5.74 0.3 2.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2479724 0.811 rs8393 chr6:41757836 C/A cg17623882 chr6:41773611 USP49 0.61 10.11 0.48 3.72e-21 Menarche (age at onset); LUSC cis rs7917772 0.582 rs4917978 chr10:104366353 C/T cg22532475 chr10:104410764 TRIM8 0.25 6.13 0.32 2.46e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs3733585 0.638 rs7377625 chr4:9953099 T/C cg26043149 chr18:55253948 FECH -0.45 -6.9 -0.35 2.65e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12541635 0.739 rs1896915 chr8:107083520 G/T cg10147462 chr8:107024639 NA 0.59 12.13 0.55 2.6e-28 Age of smoking initiation; LUSC trans rs4332037 0.539 rs62444881 chr7:2052318 C/T cg11693508 chr17:37793320 STARD3 0.56 6.59 0.34 1.67e-10 Bipolar disorder; LUSC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg25208724 chr1:156163844 SLC25A44 1.11 27.31 0.83 4.24e-87 Testicular germ cell tumor; LUSC cis rs500891 0.645 rs12190945 chr6:84162042 C/T cg08257003 chr6:84140564 ME1 -0.37 -8.84 -0.44 5.57e-17 Platelet-derived growth factor BB levels; LUSC cis rs6121246 0.909 rs6060923 chr20:30336655 A/C cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs12760731 0.565 rs12403070 chr1:178094429 A/G cg00404053 chr1:178313656 RASAL2 0.68 6.84 0.35 3.79e-11 Obesity-related traits; LUSC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg10523679 chr1:76189770 ACADM 0.9 16.2 0.66 5.81e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg03213289 chr20:61660250 NA 0.65 13.15 0.58 4.23e-32 Prostate cancer (SNP x SNP interaction); LUSC cis rs394563 0.781 rs61516098 chr6:149794289 A/T cg11245181 chr6:149772854 ZC3H12D -0.29 -6.21 -0.32 1.57e-9 Dupuytren's disease; LUSC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg20283391 chr11:68216788 NA -0.57 -8.14 -0.41 8.02e-15 Total body bone mineral density; LUSC cis rs7312933 0.558 rs11181507 chr12:42844763 T/A cg01256987 chr12:42539512 GXYLT1 -0.37 -6.86 -0.35 3.28e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg21880101 chr17:80066754 CCDC57 -0.31 -5.78 -0.3 1.76e-8 Life satisfaction; LUSC cis rs2000999 0.515 rs2854956 chr16:72115238 A/T cg16558253 chr16:72132732 DHX38 -0.42 -6.45 -0.33 4.03e-10 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; LUSC cis rs12220238 1.000 rs12355771 chr10:75894404 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 7.24 0.37 3.17e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9906944 0.713 rs9899580 chr17:47106878 T/G cg14634687 chr17:47094252 IGF2BP1 0.31 6.54 0.34 2.26e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7589342 0.801 rs2889605 chr2:106525073 T/C cg14210321 chr2:106509881 NCK2 -0.61 -9.53 -0.46 3.4e-19 Addiction; LUSC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg12751644 chr20:60527061 NA -0.35 -6.22 -0.32 1.52e-9 Body mass index; LUSC cis rs427394 0.802 rs274720 chr5:6719933 A/G cg10857441 chr5:6722123 POLS -0.47 -9.21 -0.45 3.6e-18 Menopause (age at onset); LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg00684032 chr4:1343700 KIAA1530 0.37 6.49 0.33 3.18e-10 Obesity-related traits; LUSC trans rs11764590 0.950 rs11514731 chr7:2051503 C/G cg10840412 chr1:235813424 GNG4 0.57 7.36 0.37 1.4e-12 Neuroticism; LUSC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.889 rs1789355 chr11:111499718 T/C cg19812747 chr11:111475976 SIK2 -0.52 -7.34 -0.37 1.67e-12 Primary sclerosing cholangitis; LUSC cis rs9300255 0.620 rs1716173 chr12:123660721 A/T cg00376283 chr12:123451042 ABCB9 0.66 8.34 0.42 1.94e-15 Neutrophil percentage of white cells; LUSC cis rs17102423 0.788 rs35176994 chr14:65596004 T/C cg11161011 chr14:65562177 MAX -0.73 -10.99 -0.52 3.55e-24 Obesity-related traits; LUSC cis rs9788721 0.836 rs72738736 chr15:78765122 G/T cg18825076 chr15:78729989 IREB2 -0.61 -9.95 -0.48 1.31e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2658782 0.756 rs3019222 chr11:93079718 C/T cg15737290 chr11:93063684 CCDC67 0.71 8.86 0.44 4.99e-17 Pulmonary function decline; LUSC cis rs427941 0.703 rs201442 chr7:101737627 C/T cg06246474 chr7:101738831 CUX1 -0.42 -6.92 -0.35 2.32e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23896578 chr20:8000418 TMX4 -0.4 -5.98 -0.31 5.66e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9486719 1.000 rs11153070 chr6:97039720 C/G cg06623918 chr6:96969491 KIAA0776 -0.83 -9.36 -0.46 1.17e-18 Migraine;Coronary artery disease; LUSC cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs11122272 0.735 rs2808596 chr1:231530723 A/G cg06096015 chr1:231504339 EGLN1 0.57 10.33 0.49 6.72e-22 Hemoglobin concentration; LUSC cis rs7605827 0.930 rs11684395 chr2:15530870 A/G cg19274914 chr2:15703543 NA 0.48 9.34 0.46 1.39e-18 Educational attainment (years of education); LUSC cis rs9648716 0.515 rs38715 chr7:140691563 T/C cg23214464 chr7:140373596 ADCK2 0.74 6.33 0.33 8.04e-10 Type 2 diabetes; LUSC cis rs238295 0.631 rs6038205 chr20:5549073 T/A cg15842884 chr20:5591925 RP5-1022P6.2 -0.43 -5.87 -0.31 1.07e-8 Occipital cortical area (total cortical area interaction); LUSC trans rs11039798 0.698 rs78553793 chr11:48947336 C/A cg15704280 chr7:45808275 SEPT13 0.8 6.99 0.36 1.48e-11 Axial length; LUSC cis rs2477686 0.526 rs12042427 chr1:2398107 C/T cg02275930 chr1:2372054 NA -0.55 -7.75 -0.39 1.08e-13 Non-obstructive azoospermia; LUSC cis rs72772090 0.539 rs111886458 chr5:96125047 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.96 -0.36 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs208515 0.525 rs12193034 chr6:66677866 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.17 0.61 5.27e-36 Exhaled nitric oxide levels; LUSC cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg11102782 chr19:18549136 ISYNA1 -0.35 -6.69 -0.34 9.45e-11 Breast cancer; LUSC cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg03146154 chr1:46216737 IPP -0.51 -7.35 -0.37 1.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg14552801 chr7:65878734 NA 0.43 5.89 0.31 9.18e-9 Aortic root size; LUSC cis rs2637266 0.967 rs6480826 chr10:78356154 A/G cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs2439831 0.867 rs3213991 chr15:43670280 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.06 12.91 0.58 3.43e-31 Lung cancer in ever smokers; LUSC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg20811857 chr17:78079795 GAA -0.37 -6.63 -0.34 1.32e-10 Yeast infection; LUSC cis rs2658782 0.593 rs2243410 chr11:93255519 T/G cg15737290 chr11:93063684 CCDC67 0.59 7.39 0.37 1.2e-12 Pulmonary function decline; LUSC trans rs2204008 0.683 rs11522927 chr12:38137537 C/T cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.99e-9 Bladder cancer; LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg14789911 chr21:47582049 C21orf56 -0.41 -6.46 -0.33 3.66e-10 Testicular germ cell tumor; LUSC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg05425664 chr17:57184151 TRIM37 -0.56 -8.37 -0.42 1.62e-15 Intelligence (multi-trait analysis); LUSC cis rs3820928 0.874 rs4675130 chr2:227827740 G/T cg11843606 chr2:227700838 RHBDD1 -0.51 -7.3 -0.37 2.1e-12 Pulmonary function; LUSC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg12386194 chr3:101231763 SENP7 0.65 9.03 0.44 1.4e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg09455208 chr3:40491958 NA 0.56 10.15 0.49 2.77e-21 Renal cell carcinoma; LUSC cis rs6977660 1.000 rs5017191 chr7:19820158 C/A cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg03929089 chr4:120376271 NA -0.83 -11.36 -0.53 1.64e-25 Coronary artery disease; LUSC cis rs7267979 1.000 rs2297496 chr20:25295787 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.58 -0.75 2.39e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4654899 0.965 rs17418249 chr1:21390582 C/T cg01072550 chr1:21505969 NA -0.54 -8.28 -0.41 3.02e-15 Superior frontal gyrus grey matter volume; LUSC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg17158414 chr2:27665306 KRTCAP3 0.32 6.29 0.33 9.71e-10 Total body bone mineral density; LUSC cis rs1832871 0.672 rs9456286 chr6:158734315 A/G cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs208515 0.525 rs12214310 chr6:66666308 A/G cg07460842 chr6:66804631 NA 1.04 14.11 0.61 9.12e-36 Exhaled nitric oxide levels; LUSC cis rs1790761 0.667 rs591434 chr11:67337814 C/T cg14500267 chr11:67383377 NA 0.34 6.51 0.34 2.75e-10 Mean corpuscular volume; LUSC cis rs950169 0.810 rs62029594 chr15:84955252 T/C cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.64e-15 Schizophrenia; LUSC cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.23 -0.32 1.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8017423 0.967 rs12889636 chr14:90689953 A/C cg14092571 chr14:90743983 NA 0.36 5.82 0.3 1.39e-8 Mortality in heart failure; LUSC cis rs9393692 0.645 rs9467703 chr6:26318903 A/G cg13736514 chr6:26305472 NA -0.54 -10.66 -0.5 4.97e-23 Educational attainment; LUSC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg11812906 chr14:75593930 NEK9 -0.58 -9.76 -0.47 5.61e-20 Height; LUSC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg18479299 chr3:125709523 NA -0.51 -5.85 -0.31 1.14e-8 Blood pressure (smoking interaction); LUSC cis rs9467773 0.967 rs9358954 chr6:26531178 A/G cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.88e-18 Intelligence (multi-trait analysis); LUSC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg13393036 chr8:95962371 TP53INP1 -0.46 -9.49 -0.46 4.58e-19 Type 2 diabetes; LUSC cis rs2639990 1.000 rs655156 chr18:72898181 T/C cg03972071 chr18:72917163 ZADH2 0.47 5.74 0.3 2.09e-8 Vascular endothelial growth factor levels; LUSC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg27170947 chr2:26402098 FAM59B -0.7 -10.37 -0.49 4.89e-22 Gut microbiome composition (summer); LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg13560548 chr3:10150139 C3orf24 0.54 7.74 0.39 1.17e-13 Alzheimer's disease; LUSC cis rs6998277 0.830 rs6468838 chr8:103609336 T/C cg10187029 chr8:103597600 NA 0.78 11.95 0.55 1.18e-27 Migraine; LUSC cis rs6062509 0.839 rs3859579 chr20:62301795 A/G cg16989086 chr20:62203971 PRIC285 -0.41 -5.84 -0.3 1.24e-8 Prostate cancer; LUSC cis rs8133932 0.654 rs425232 chr21:47346525 G/T cg14185626 chr21:47401492 COL6A1 -0.44 -5.65 -0.3 3.37e-8 Schizophrenia; LUSC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18099408 chr3:52552593 STAB1 -0.43 -7.67 -0.39 1.95e-13 Bipolar disorder; LUSC cis rs9473147 0.516 rs9349413 chr6:47511491 A/G cg12968598 chr6:47444699 CD2AP 0.51 7.32 0.37 1.92e-12 Platelet distribution width;Mean platelet volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17449403 chr12:48357323 TMEM106C -0.52 -6.54 -0.34 2.33e-10 Bipolar disorder and schizophrenia; LUSC cis rs6977940 0.822 rs6978804 chr7:2902698 T/C cg19731401 chr7:2775893 GNA12 0.66 8.07 0.4 1.31e-14 White matter integrity; LUSC cis rs36715 1.000 rs36705 chr5:127554486 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.54 7.37 0.37 1.32e-12 Breast cancer; LUSC cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg24692254 chr21:30365293 RNF160 -0.54 -8.01 -0.4 1.87e-14 Dental caries; LUSC cis rs672059 1.000 rs549844 chr1:183158143 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.55 -8.14 -0.41 7.71e-15 Hypertriglyceridemia; LUSC trans rs1908814 0.516 rs11250178 chr8:11800234 A/C cg08975724 chr8:8085496 FLJ10661 0.46 6.65 0.34 1.23e-10 Neuroticism; LUSC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg09913183 chr17:42254507 C17orf65;ASB16 -0.57 -8.96 -0.44 2.32e-17 Total body bone mineral density; LUSC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg19901468 chr14:105411992 AHNAK2 -0.67 -11.95 -0.55 1.23e-27 Rheumatoid arthritis; LUSC cis rs593982 0.920 rs76925283 chr11:65548108 C/T cg08755490 chr11:65554678 OVOL1 -1.5 -15.04 -0.64 2.04e-39 Atopic dermatitis; LUSC cis rs56159542 1 rs56159542 chr19:19682971 T/C cg11244672 chr19:19639970 YJEFN3 0.47 6.2 0.32 1.69e-9 Attention deficit hyperactivity disorder symptom score; LUSC cis rs4555082 0.874 rs28785556 chr14:105745388 A/T cg10792982 chr14:105748885 BRF1 0.49 8.52 0.42 5.44e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs116095464 0.558 rs10059907 chr5:205360 G/C cg22496380 chr5:211416 CCDC127 -0.85 -8.68 -0.43 1.72e-16 Breast cancer; LUSC cis rs7089973 0.628 rs11196953 chr10:116607707 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12618769 0.597 rs3769740 chr2:99069208 A/G cg10123293 chr2:99228465 UNC50 -0.41 -7.03 -0.36 1.16e-11 Bipolar disorder; LUSC cis rs12980942 0.748 rs67511749 chr19:41825158 A/G cg25627403 chr19:41769009 HNRNPUL1 0.56 6.08 0.32 3.22e-9 Coronary artery disease; LUSC cis rs7712401 0.791 rs4836244 chr5:122116232 A/G cg19077854 chr5:122220652 SNX24 0.33 7.29 0.37 2.33e-12 Mean platelet volume; LUSC trans rs2055729 0.710 rs13257396 chr8:9736383 A/C cg06636001 chr8:8085503 FLJ10661 0.49 6.22 0.32 1.49e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg02117656 chr17:79614917 TSPAN10 0.31 5.69 0.3 2.75e-8 Eye color traits; LUSC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs4729127 1.000 rs73426361 chr7:94012656 G/T cg14660007 chr13:78271894 SLAIN1 0.5 6.44 0.33 4.28e-10 Intelligence; LUSC cis rs35123781 1.000 rs600848 chr5:139057270 T/C cg10513866 chr5:139070639 NA 0.46 8.9 0.44 3.62e-17 Schizophrenia; LUSC trans rs11165623 0.585 rs6698447 chr1:96999473 C/T cg10631902 chr5:14652156 NA -0.41 -6.06 -0.31 3.69e-9 Hip circumference;Waist circumference; LUSC cis rs68170813 0.559 rs12537011 chr7:107027833 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.34 -0.45 1.45e-18 Coronary artery disease; LUSC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg08798685 chr6:27730294 NA -0.63 -5.94 -0.31 7.03e-9 Depression; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg22920501 chr2:26401640 FAM59B -0.79 -11.76 -0.54 5.97e-27 Gut microbiome composition (summer); LUSC cis rs4356932 1.000 rs6532158 chr4:76977964 A/G cg00809888 chr4:76862425 NAAA 0.34 5.69 0.3 2.75e-8 Blood protein levels; LUSC cis rs1030268 0.667 rs12707111 chr7:133330144 C/T cg10665199 chr7:133106180 EXOC4 0.63 7.39 0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg05738196 chr6:26577821 NA -0.59 -6.93 -0.35 2.12e-11 Intelligence (multi-trait analysis); LUSC cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 7.52 0.38 5.23e-13 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05063087 chr10:102133314 C10orf75 0.4 6.0 0.31 5.14e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.0 0.58 1.44e-31 Cognitive test performance; LUSC cis rs7119 0.651 rs34607443 chr15:77847892 C/T cg27398640 chr15:77910606 LINGO1 -0.33 -7.04 -0.36 1.12e-11 Type 2 diabetes; LUSC cis rs12200782 0.530 rs6929908 chr6:26555289 C/A cg05738196 chr6:26577821 NA 0.5 5.69 0.3 2.72e-8 Small cell lung carcinoma; LUSC cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg23711669 chr6:146136114 FBXO30 -0.92 -18.2 -0.71 6.3e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs950027 0.620 rs1617984 chr15:45622662 A/G cg09092052 chr15:45571596 NA -0.43 -6.07 -0.32 3.38e-9 Response to fenofibrate (adiponectin levels); LUSC trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg25482853 chr8:67687455 SGK3 1.2 17.05 0.68 2.38e-47 Lung disease severity in cystic fibrosis; LUSC cis rs2280018 1.000 rs2280017 chr16:15151361 A/G cg27102117 chr16:15229624 NA -0.4 -6.91 -0.35 2.54e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg05535760 chr7:792225 HEATR2 0.79 9.23 0.45 3.21e-18 Cerebrospinal P-tau181p levels; LUSC cis rs9875589 0.509 rs2731332 chr3:14110083 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 6.87 0.35 3.21e-11 Ovarian reserve; LUSC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg18230493 chr5:56204884 C5orf35 0.77 12.72 0.57 1.65e-30 Initial pursuit acceleration; LUSC cis rs17270561 0.779 rs78589800 chr6:25883500 C/G cg16482183 chr6:26056742 HIST1H1C 0.86 11.64 0.54 1.65e-26 Iron status biomarkers; LUSC cis rs4803468 0.763 rs17318596 chr19:41937095 A/G cg09537434 chr19:41945824 ATP5SL -0.9 -15.26 -0.64 3.01e-40 Height; LUSC cis rs977987 0.866 rs12932606 chr16:75493944 C/T cg04384234 chr16:75411784 CFDP1 -0.48 -7.89 -0.4 4.26e-14 Dupuytren's disease; LUSC cis rs11608355 0.545 rs2302705 chr12:109898716 C/T cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs1018836 0.828 rs1858673 chr8:91551526 C/A cg16814680 chr8:91681699 NA -0.7 -11.4 -0.53 1.22e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.82 12.65 0.57 3.01e-30 IgG glycosylation; LUSC cis rs11971779 0.618 rs13068 chr7:139104141 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg18252515 chr7:66147081 NA -1.21 -13.51 -0.59 1.77e-33 Diabetic kidney disease; LUSC cis rs10927875 0.632 rs10927864 chr1:16165661 C/G cg22431228 chr1:16359049 CLCNKA 0.34 6.39 0.33 5.62e-10 Dilated cardiomyopathy; LUSC cis rs7727544 0.716 rs7701414 chr5:131585958 A/G cg18758796 chr5:131593413 PDLIM4 0.34 5.92 0.31 8.06e-9 Blood metabolite levels; LUSC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.59 0.6 8.31e-34 Platelet count; LUSC trans rs2864527 0.522 rs72939227 chr18:9249117 G/A cg19809734 chr13:112772980 NA -0.58 -5.99 -0.31 5.39e-9 Dental caries; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19078334 chr9:113019254 TXN 0.48 6.87 0.35 3.14e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs73129298 0.551 rs6020177 chr20:48603324 C/T cg25655593 chr20:48599521 SNAI1 0.56 5.94 0.31 7.12e-9 Inflammatory skin disease; LUSC cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg05340658 chr4:99064831 C4orf37 0.69 11.82 0.54 3.47e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.752 rs72796130 chr2:23919740 T/C cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.4e-12 Lymphocyte counts; LUSC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.63 13.47 0.59 2.44e-33 Monocyte percentage of white cells; LUSC cis rs7917772 0.560 rs3862030 chr10:104327584 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1385374 0.858 rs959989 chr12:129292708 A/T cg09035930 chr12:129282057 SLC15A4 -0.64 -6.8 -0.35 4.96e-11 Systemic lupus erythematosus; LUSC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg15445000 chr17:37608096 MED1 0.38 6.48 0.33 3.24e-10 Glomerular filtration rate (creatinine); LUSC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg08045932 chr20:61659980 NA 0.58 10.07 0.48 5.3e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg27284194 chr4:1044797 NA 0.38 6.51 0.34 2.73e-10 Obesity-related traits; LUSC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg00933542 chr6:150070202 PCMT1 0.35 7.05 0.36 1.03e-11 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06474323 chr17:38257020 NR1D1 -0.44 -6.64 -0.34 1.27e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg23283495 chr1:209979779 IRF6 0.65 7.77 0.39 9.56e-14 Coronary artery disease; LUSC cis rs11098499 0.818 rs12498599 chr4:120468503 C/T cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.66e-25 Corneal astigmatism; LUSC cis rs981844 0.857 rs62325141 chr4:154716407 A/G cg14289246 chr4:154710475 SFRP2 0.48 6.13 0.32 2.54e-9 Response to statins (LDL cholesterol change); LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg07677032 chr17:61819896 STRADA 0.53 8.91 0.44 3.42e-17 Prudent dietary pattern; LUSC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg23649088 chr2:200775458 C2orf69 0.54 7.25 0.37 2.86e-12 Schizophrenia; LUSC cis rs2115630 0.967 rs10438428 chr15:85330745 C/T cg11189052 chr15:85197271 WDR73 -0.44 -6.51 -0.34 2.78e-10 P wave terminal force; LUSC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg23158103 chr7:148848205 ZNF398 -0.48 -7.82 -0.39 6.83e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs6601327 0.613 rs10094989 chr8:9612009 T/C cg06636001 chr8:8085503 FLJ10661 0.45 6.14 0.32 2.31e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs5009270 0.512 rs1024410 chr7:112247542 A/T cg27282281 chr7:112262583 NA 0.44 5.96 0.31 6.49e-9 Osteoarthritis (hip); LUSC cis rs7191439 0.728 rs8043637 chr16:88781125 T/C cg27087555 chr16:88793112 FAM38A -1.41 -13.58 -0.6 9.7e-34 Plateletcrit; LUSC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.33e-10 Height; LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg25428297 chr7:1022841 CYP2W1 -0.29 -6.29 -0.33 9.88e-10 Longevity;Endometriosis; LUSC cis rs1348850 0.651 rs4893936 chr2:178240676 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.53 0.34 2.41e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg21280719 chr6:42927975 GNMT -0.31 -7.76 -0.39 1.02e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg13390004 chr1:15929781 NA 0.42 6.95 0.36 1.92e-11 Systolic blood pressure; LUSC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg01191920 chr7:158217561 PTPRN2 0.45 9.0 0.44 1.75e-17 Obesity-related traits; LUSC cis rs4780401 0.609 rs4781141 chr16:11808769 A/C cg01061890 chr16:11836724 TXNDC11 -0.56 -8.63 -0.43 2.52e-16 Rheumatoid arthritis; LUSC cis rs3820928 1.000 rs11692572 chr2:227774503 C/G cg11843606 chr2:227700838 RHBDD1 -0.54 -8.12 -0.41 9.3e-15 Pulmonary function; LUSC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg05802129 chr4:122689817 NA -0.34 -5.98 -0.31 5.69e-9 Type 2 diabetes; LUSC cis rs911119 0.913 rs6048923 chr20:23578206 C/T cg16589663 chr20:23618590 CST3 0.63 7.32 0.37 1.85e-12 Chronic kidney disease; LUSC cis rs76419734 0.510 rs2553456 chr4:106751028 T/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.51 -5.75 -0.3 1.98e-8 Post bronchodilator FEV1; LUSC trans rs9650657 0.504 rs10108347 chr8:11033517 G/C cg08975724 chr8:8085496 FLJ10661 -0.43 -6.09 -0.32 3.11e-9 Neuroticism; LUSC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.75 0.3 1.98e-8 Life satisfaction; LUSC cis rs668210 0.793 rs502363 chr11:65775592 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.57 7.6 0.38 3e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg15691649 chr6:25882328 NA -0.38 -6.28 -0.33 1.04e-9 Blood metabolite levels; LUSC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg11062466 chr8:58055876 NA 0.71 8.6 0.43 3.25e-16 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.51 0.56 1e-29 Motion sickness; LUSC cis rs7617773 0.851 rs6775179 chr3:48313418 T/C cg20734569 chr3:48348370 SPINK8 -0.48 -8.29 -0.41 2.74e-15 Coronary artery disease; LUSC cis rs360798 0.512 rs2215870 chr2:63132342 C/G cg17519650 chr2:63277830 OTX1 0.5 7.03 0.36 1.17e-11 Coronary artery disease; LUSC cis rs453301 0.624 rs2288671 chr8:8860894 T/C cg06636001 chr8:8085503 FLJ10661 0.63 9.72 0.47 7.93e-20 Joint mobility (Beighton score); LUSC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.45 6.21 0.32 1.58e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9660992 0.649 rs72745216 chr1:205261016 G/A cg00857998 chr1:205179979 DSTYK 0.62 9.52 0.46 3.48e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg05368731 chr17:41323189 NBR1 0.92 15.58 0.65 1.65e-41 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13435101 chr6:74171350 MTO1 -0.5 -6.84 -0.35 3.87e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7084921 0.579 rs2862951 chr10:101844948 A/C cg02250046 chr10:101825185 CPN1 -0.33 -5.93 -0.31 7.42e-9 Bone mineral density; LUSC cis rs6700559 0.740 rs4072551 chr1:200649121 A/G cg07804481 chr1:200639085 DDX59 0.41 5.77 0.3 1.85e-8 Coronary artery disease; LUSC cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.14 0.58 4.36e-32 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9875589 0.509 rs6770928 chr3:14077189 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.16 0.36 5.12e-12 Ovarian reserve; LUSC cis rs11971779 0.590 rs9642120 chr7:139083971 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7267979 0.586 rs1473695 chr20:25186965 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.63 0.57 3.69e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6977660 0.891 rs10226962 chr7:19819464 T/C cg07541023 chr7:19748670 TWISTNB 0.52 5.84 0.3 1.26e-8 Thyroid stimulating hormone; LUSC cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg00677455 chr12:58241039 CTDSP2 0.62 8.75 0.43 1.09e-16 Multiple sclerosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02484111 chr11:130318594 ADAMTS15 -0.47 -6.25 -0.32 1.25e-9 Bipolar disorder and schizophrenia; LUSC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg18876405 chr7:65276391 NA 0.75 13.5 0.59 1.95e-33 Calcium levels; LUSC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.82 0.39 7.1e-14 Electroencephalogram traits; LUSC trans rs4948088 0.744 rs2189822 chr7:51017361 A/G cg26816907 chr1:197890812 LHX9 0.56 6.21 0.32 1.62e-9 Type 1 diabetes; LUSC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.95 0.31 6.59e-9 Intelligence (multi-trait analysis); LUSC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg19678392 chr7:94953810 PON1 -0.36 -5.67 -0.3 3.12e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg26384229 chr12:38710491 ALG10B 0.93 17.4 0.69 1.02e-48 Heart rate; LUSC cis rs2014572 0.967 rs10413037 chr19:57771883 A/G cg24459738 chr19:57751996 ZNF805 -0.5 -7.24 -0.37 3.05e-12 Hyperactive-impulsive symptoms; LUSC cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.84 0.44 5.57e-17 Motion sickness; LUSC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg06108461 chr20:60628389 TAF4 0.67 8.89 0.44 4.01e-17 Obesity-related traits; LUSC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19346786 chr7:2764209 NA -0.36 -6.2 -0.32 1.62e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg02150526 chr17:38136938 PSMD3 0.41 6.2 0.32 1.62e-9 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T ch.1.159013533R chr1:160746909 NA 0.42 6.49 0.33 3.05e-10 Triglycerides; LUSC cis rs208520 0.690 rs10944872 chr6:66708239 T/G cg07460842 chr6:66804631 NA 1.06 16.43 0.67 7.12e-45 Exhaled nitric oxide output; LUSC cis rs273573 1.000 rs273605 chr11:30965855 A/T cg14844989 chr11:31128820 NA 0.36 5.82 0.3 1.38e-8 Total body bone mineral density; LUSC trans rs10096351 0.550 rs78015822 chr8:128336740 A/G cg10195415 chr17:73887371 TRIM65 0.4 6.37 0.33 6.34e-10 Breast cancer; LUSC cis rs10782582 0.609 rs5745331 chr1:76273313 A/G cg10523679 chr1:76189770 ACADM -0.46 -6.67 -0.34 1.09e-10 Daytime sleep phenotypes; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.74 0.77 6.18e-66 Prudent dietary pattern; LUSC cis rs1670533 1.000 rs652063 chr4:1084137 T/C cg02018176 chr4:1364513 KIAA1530 0.45 6.42 0.33 4.68e-10 Recombination rate (females); LUSC trans rs6074022 0.956 rs1569723 chr20:44742064 A/C cg11245233 chr1:76251899 SNORD45C;RABGGTB 0.42 6.02 0.31 4.5e-9 Crohn's disease;Inflammatory bowel disease;Multiple sclerosis; LUSC cis rs3857536 0.813 rs7770349 chr6:66946659 G/T cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs11098499 0.605 rs6833140 chr4:120266822 G/A cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.4e-19 Corneal astigmatism; LUSC trans rs3733585 0.673 rs6836706 chr4:9964251 T/A cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6964587 0.967 rs6980247 chr7:91594228 T/A cg01689657 chr7:91764605 CYP51A1 0.31 5.66 0.3 3.2e-8 Breast cancer; LUSC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg04287289 chr16:89883240 FANCA 0.79 13.95 0.61 3.5e-35 Vitiligo; LUSC cis rs2839186 0.504 rs4347941 chr21:47938239 T/C cg10657630 chr21:48055338 PRMT2 0.4 6.12 0.32 2.63e-9 Testicular germ cell tumor; LUSC cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg11752832 chr7:134001865 SLC35B4 0.49 7.13 0.36 6.29e-12 Mean platelet volume; LUSC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg26408565 chr15:76604113 ETFA -0.5 -8.11 -0.41 1.01e-14 Blood metabolite levels; LUSC cis rs4631830 0.720 rs2843560 chr10:51512129 C/G cg16070123 chr10:51489643 NA 0.56 9.22 0.45 3.44e-18 Prostate-specific antigen levels; LUSC cis rs9467773 0.620 rs2504600 chr6:26648334 C/A cg11502198 chr6:26597334 ABT1 0.73 12.25 0.56 9.63e-29 Intelligence (multi-trait analysis); LUSC cis rs6867032 1.000 rs6867032 chr5:2015103 G/T cg26168224 chr5:2018326 NA -0.82 -16.44 -0.67 6.37e-45 Gut microbiome composition (winter); LUSC cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg06484146 chr7:12443880 VWDE 0.55 5.76 0.3 1.92e-8 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03559815 chr11:117199307 CEP164 -0.43 -6.47 -0.33 3.46e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs911555 0.755 rs975892 chr14:103883349 A/T cg24130564 chr14:104152367 KLC1 -0.44 -6.47 -0.33 3.43e-10 Intelligence (multi-trait analysis); LUSC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.96 -0.31 6.47e-9 Alzheimer's disease (late onset); LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg08859206 chr1:53392774 SCP2 0.5 8.42 0.42 1.11e-15 Monocyte count; LUSC cis rs2070488 0.775 rs9838614 chr3:38537671 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -12.42 -0.56 2.27e-29 Electrocardiographic conduction measures; LUSC cis rs11630290 0.592 rs1912048 chr15:64155974 G/A cg12036633 chr15:63758958 NA 0.52 6.64 0.34 1.26e-10 Iris characteristics; LUSC cis rs7107174 1.000 rs11237438 chr11:77998488 T/C cg02023728 chr11:77925099 USP35 0.47 6.74 0.35 6.97e-11 Testicular germ cell tumor; LUSC cis rs1577917 1.000 rs7760207 chr6:86721700 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.22 -0.41 4.54e-15 Response to antipsychotic treatment; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg11965913 chr1:205819406 PM20D1 -0.93 -19.12 -0.72 1.49e-55 Menarche (age at onset); LUSC cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg13010199 chr12:38710504 ALG10B 0.49 7.5 0.38 6e-13 Morning vs. evening chronotype; LUSC cis rs1991651 0.507 rs17778581 chr8:10743421 C/T cg21775007 chr8:11205619 TDH -0.52 -7.03 -0.36 1.16e-11 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; LUSC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg27529037 chr20:44575021 PCIF1 0.4 7.06 0.36 9.42e-12 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.517 rs7960878 chr12:34055645 C/A cg26384229 chr12:38710491 ALG10B 0.72 11.36 0.53 1.66e-25 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.75 0.43 1.09e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7937682 0.921 rs12806479 chr11:111443192 G/C cg18187862 chr3:45730750 SACM1L -0.49 -6.09 -0.32 3.14e-9 Primary sclerosing cholangitis; LUSC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04644883 chr4:141071988 MAML3 -0.45 -6.0 -0.31 5.13e-9 Hepatitis; LUSC cis rs9513627 0.588 rs9585073 chr13:100128516 A/G cg25919922 chr13:100150906 NA -0.75 -6.44 -0.33 4.11e-10 Obesity-related traits; LUSC cis rs7793919 0.726 rs10232008 chr7:4783206 T/G cg09789173 chr7:4769017 FOXK1 0.63 11.51 0.53 4.86e-26 Mosquito bite size; LUSC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg07936489 chr17:37558343 FBXL20 0.72 9.96 0.48 1.28e-20 Glomerular filtration rate (creatinine); LUSC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg15534755 chr11:117069859 TAGLN -0.33 -5.82 -0.3 1.39e-8 Blood protein levels; LUSC trans rs11098499 0.954 rs28429722 chr4:120300093 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg04352962 chr1:209979756 IRF6 0.53 7.07 0.36 9.27e-12 Cleft lip with or without cleft palate; LUSC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg14703610 chr5:56206110 C5orf35 0.41 5.87 0.31 1.04e-8 Coronary artery disease; LUSC cis rs834811 0.829 rs6980107 chr7:135900757 C/T cg01726295 chr7:135938950 NA -0.4 -7.13 -0.36 6.36e-12 Post-traumatic stress disorder; LUSC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg24675658 chr1:53192096 ZYG11B 0.73 12.29 0.56 6.6e-29 Monocyte count; LUSC cis rs7267979 0.932 rs2387891 chr20:25470328 C/G cg08601574 chr20:25228251 PYGB 0.43 6.5 0.34 2.92e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1472147 0.955 rs3736611 chr7:128509243 C/G cg00260937 chr7:128520193 KCP 0.44 5.88 0.31 9.92e-9 Calcium levels; LUSC cis rs6714710 0.603 rs895438 chr2:98382886 G/A cg26665480 chr2:98280029 ACTR1B 0.64 9.18 0.45 4.7e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs17828380 1.000 rs71393141 chr15:63534181 T/C cg05507819 chr15:63340323 TPM1 -0.7 -5.93 -0.31 7.7e-9 Social communication problems; LUSC cis rs61931739 0.534 rs11053014 chr12:34103519 G/A cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs12760731 0.565 rs12027723 chr1:178090271 A/T cg00404053 chr1:178313656 RASAL2 0.69 6.75 0.35 6.64e-11 Obesity-related traits; LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.38 0.37 1.26e-12 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04393675 chr16:28986095 SPNS1 -0.52 -6.39 -0.33 5.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs13401104 0.796 rs72620808 chr2:237114372 G/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.35e-8 Educational attainment; LUSC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg12826209 chr6:26865740 GUSBL1 0.73 8.92 0.44 3.1e-17 Intelligence (multi-trait analysis); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17965230 chr6:106534206 PRDM1 -0.5 -6.49 -0.33 3.19e-10 Hepatitis; LUSC cis rs9314323 0.964 rs3808576 chr8:26266834 G/A cg11498726 chr8:26250323 BNIP3L -0.41 -6.0 -0.31 5.03e-9 Red cell distribution width; LUSC trans rs853679 0.546 rs13195291 chr6:28169241 G/A cg06606381 chr12:133084897 FBRSL1 -1.06 -9.14 -0.45 6.21e-18 Depression; LUSC cis rs601339 1.000 rs635400 chr12:123171089 A/G cg11919336 chr12:123188078 GPR109A 0.4 5.98 0.31 5.86e-9 Adiponectin levels; LUSC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg25072359 chr17:41440525 NA 0.63 9.17 0.45 4.92e-18 Menopause (age at onset); LUSC cis rs9325144 0.647 rs7980932 chr12:38921583 G/T cg13010199 chr12:38710504 ALG10B -0.49 -7.39 -0.37 1.17e-12 Morning vs. evening chronotype; LUSC cis rs1256061 0.646 rs1256056 chr14:64712626 A/G cg21174375 chr14:64681225 SYNE2 0.34 6.15 0.32 2.22e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7746199 0.736 rs13210634 chr6:27646492 A/G cg26958806 chr6:27640298 NA 0.75 6.01 0.31 4.76e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1878931 1.000 rs1878931 chr16:3450907 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.83 14.14 0.61 6.9e-36 Body mass index (adult); LUSC cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg09998033 chr7:158218633 PTPRN2 -0.6 -9.57 -0.46 2.48e-19 Obesity-related traits; LUSC cis rs12681287 0.640 rs7460650 chr8:87474085 A/G cg00550725 chr8:87521180 FAM82B 0.42 5.7 0.3 2.65e-8 Caudate activity during reward; LUSC cis rs6138458 1.000 rs2387362 chr20:24899906 C/T cg26195577 chr20:24973756 C20orf3 -1.12 -18.25 -0.71 4.21e-52 Blood protein levels; LUSC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg26597838 chr10:835615 NA 1.0 14.04 0.61 1.6e-35 Eosinophil percentage of granulocytes; LUSC trans rs6502050 0.835 rs8079389 chr17:80158656 T/G cg07393940 chr7:158741817 NA 0.36 6.53 0.34 2.49e-10 Life satisfaction; LUSC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg14562523 chr21:43528734 C21orf128;UMODL1 -0.36 -6.2 -0.32 1.62e-9 IgG glycosylation; LUSC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs7973719 0.899 rs12424618 chr12:7344802 A/G cg07052231 chr12:7363540 PEX5 0.53 9.17 0.45 5.13e-18 IgG glycosylation; LUSC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg18876405 chr7:65276391 NA -0.58 -9.51 -0.46 4.03e-19 Aortic root size; LUSC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg00484396 chr16:3507460 NAT15 -0.71 -11.48 -0.53 6.12e-26 Tuberculosis; LUSC cis rs10911232 0.507 rs9787327 chr1:182978459 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Hypertriglyceridemia; LUSC cis rs1728785 0.681 rs4783647 chr16:68558048 G/A cg02508848 chr16:68573721 ZFP90 0.46 5.88 0.31 9.69e-9 Ulcerative colitis; LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg13047869 chr3:10149882 C3orf24 0.56 7.73 0.39 1.24e-13 Alzheimer's disease; LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.04 0.52 2.25e-24 Menopause (age at onset); LUSC cis rs372883 0.532 rs388707 chr21:30714776 T/C cg08807101 chr21:30365312 RNF160 -0.49 -7.13 -0.36 6.23e-12 Pancreatic cancer; LUSC trans rs11098499 0.954 rs4577559 chr4:120404043 T/G cg25214090 chr10:38739885 LOC399744 0.54 8.05 0.4 1.44e-14 Corneal astigmatism; LUSC cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg18404041 chr3:52824283 ITIH1 -0.49 -7.87 -0.4 5.07e-14 Schizophrenia; LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg13395646 chr4:1353034 KIAA1530 -0.56 -8.58 -0.42 3.67e-16 Obesity-related traits; LUSC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg26695010 chr11:65641043 EFEMP2 0.42 6.05 0.31 3.93e-9 Breast cancer; LUSC cis rs6700896 0.897 rs2375805 chr1:66156567 C/T cg04111102 chr1:66153794 NA 0.34 7.45 0.38 8.23e-13 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg12923728 chr3:195709715 SDHAP1 -0.8 -12.51 -0.56 1.02e-29 Pancreatic cancer; LUSC cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.88 -0.51 8.54e-24 Chronic sinus infection; LUSC cis rs12760731 0.565 rs12037925 chr1:178160268 C/T cg00404053 chr1:178313656 RASAL2 0.68 7.0 0.36 1.42e-11 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03168293 chr4:141348581 CLGN 0.45 6.13 0.32 2.53e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg08873628 chr1:175162347 KIAA0040 0.39 5.68 0.3 2.99e-8 Alcohol dependence; LUSC cis rs11122272 0.764 rs4486439 chr1:231477470 C/T cg06096015 chr1:231504339 EGLN1 0.53 9.02 0.44 1.53e-17 Hemoglobin concentration; LUSC cis rs4494114 1.000 rs7547273 chr1:39372590 G/A cg25970120 chr1:39325951 RRAGC -0.4 -6.22 -0.32 1.47e-9 Blood protein levels; LUSC cis rs3808502 0.503 rs2061830 chr8:11397457 C/G cg27411982 chr8:10470053 RP1L1 0.39 6.0 0.31 5.02e-9 Neuroticism; LUSC cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg03146154 chr1:46216737 IPP -0.5 -7.24 -0.37 3.08e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs899997 1.000 rs11072793 chr15:79006442 C/T cg24631222 chr15:78858424 CHRNA5 -0.41 -5.67 -0.3 3.01e-8 Coronary artery disease or large artery stroke; LUSC cis rs6060717 0.536 rs11699899 chr20:34525646 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -5.8 -0.3 1.53e-8 Hip circumference adjusted for BMI; LUSC cis rs2072499 0.865 rs2758603 chr1:156198994 T/C cg25208724 chr1:156163844 SLC25A44 1.04 21.6 0.76 2.26e-65 Testicular germ cell tumor; LUSC cis rs9611519 0.929 rs9611469 chr22:41433319 T/C cg03806693 chr22:41940476 POLR3H -0.5 -6.88 -0.35 2.97e-11 Neuroticism; LUSC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg04369109 chr6:150039330 LATS1 -0.56 -8.22 -0.41 4.65e-15 Lung cancer; LUSC trans rs2285002 0.745 rs229674 chr14:65281472 G/C cg17546478 chr3:184322189 NA -0.29 -5.99 -0.31 5.47e-9 Red cell distribution width; LUSC cis rs2219968 0.923 rs35392911 chr8:78976979 C/A cg00738934 chr8:78996279 NA 0.35 6.33 0.33 7.89e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg11764359 chr7:65958608 NA 0.69 11.09 0.52 1.48e-24 Aortic root size; LUSC cis rs4820294 1.000 rs7291867 chr22:38062112 C/G cg21798802 chr22:38057573 PDXP 0.48 10.36 0.49 5.35e-22 Fat distribution (HIV); LUSC cis rs10493773 0.577 rs17398175 chr1:86074710 A/G cg17807903 chr1:86174739 ZNHIT6 -0.39 -7.6 -0.38 2.99e-13 Urate levels in overweight individuals; LUSC cis rs7189233 0.955 rs72801821 chr16:53479652 G/A cg04059762 chr16:53544020 NA -0.31 -5.67 -0.3 3.09e-8 Intelligence (multi-trait analysis); LUSC cis rs3931020 0.688 rs968358 chr1:75193989 G/T cg10128416 chr1:75198403 TYW3;CRYZ 0.63 8.37 0.42 1.57e-15 Resistin levels; LUSC cis rs155346 1.000 rs645850 chr5:139393417 T/C cg01090482 chr5:139365336 NRG2 -0.38 -6.56 -0.34 2.1e-10 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs6088580 0.543 rs13042351 chr20:33238573 G/A cg24642439 chr20:33292090 TP53INP2 -0.52 -8.05 -0.4 1.45e-14 Glomerular filtration rate (creatinine); LUSC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.81 -0.3 1.44e-8 Alzheimer's disease (late onset); LUSC cis rs4629180 1.000 rs13031791 chr2:102108790 T/C cg04415270 chr2:102091202 RFX8 0.57 9.26 0.45 2.61e-18 Chronic rhinosinusitis with nasal polyps; LUSC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -11.92 -0.55 1.53e-27 Extrinsic epigenetic age acceleration; LUSC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg04756594 chr16:24857601 SLC5A11 0.47 7.02 0.36 1.21e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg02269571 chr22:50332266 NA 0.57 8.58 0.43 3.6e-16 Schizophrenia; LUSC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.47 7.23 0.37 3.25e-12 Colorectal cancer; LUSC cis rs4285028 0.580 rs12496036 chr3:121640362 G/A cg20356878 chr3:121714668 ILDR1 -0.45 -6.81 -0.35 4.63e-11 Multiple sclerosis; LUSC cis rs11105298 0.891 rs10858879 chr12:89886578 A/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.52 7.14 0.36 5.85e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9905704 0.647 rs7221274 chr17:57008128 A/G cg12560992 chr17:57184187 TRIM37 0.58 9.32 0.45 1.65e-18 Testicular germ cell tumor; LUSC cis rs988712 0.705 rs4923463 chr11:27672500 A/G cg10635145 chr11:27742435 BDNF -0.46 -6.06 -0.31 3.76e-9 Obesity; LUSC cis rs6582630 0.634 rs10748443 chr12:38734062 G/T cg13010199 chr12:38710504 ALG10B 0.47 7.3 0.37 2.09e-12 Drug-induced liver injury (flucloxacillin); LUSC cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg23788917 chr6:8435910 SLC35B3 -0.5 -7.18 -0.37 4.56e-12 Motion sickness; LUSC cis rs3859192 0.577 rs25645 chr17:38173143 G/A cg17467752 chr17:38218738 THRA -0.51 -7.2 -0.37 4.05e-12 White blood cell count; LUSC cis rs6456156 0.586 rs6456149 chr6:167463902 T/C cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.18e-8 Primary biliary cholangitis; LUSC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11644478 chr21:40555479 PSMG1 -0.62 -9.68 -0.47 1.04e-19 Menarche (age at onset); LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg27284194 chr4:1044797 NA 0.35 5.85 0.31 1.15e-8 Obesity-related traits; LUSC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg03526776 chr6:41159608 TREML2 0.32 6.12 0.32 2.68e-9 Alzheimer's disease (late onset); LUSC cis rs17270561 0.541 rs12192932 chr6:25911502 A/G cg16482183 chr6:26056742 HIST1H1C 1.01 12.91 0.58 3.43e-31 Iron status biomarkers; LUSC trans rs1814175 0.935 rs6485999 chr11:49658986 G/C cg15704280 chr7:45808275 SEPT13 -1.09 -22.07 -0.77 3.31e-67 Height; LUSC cis rs6977660 0.562 rs12112698 chr7:19781431 A/G cg05791153 chr7:19748676 TWISTNB 0.67 7.0 0.36 1.43e-11 Thyroid stimulating hormone; LUSC cis rs977987 0.815 rs11861810 chr16:75461829 A/G cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.39 6.72 0.35 7.89e-11 High light scatter reticulocyte count; LUSC cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.75 0.43 1.1e-16 Axial length; LUSC trans rs6502050 0.799 rs58538819 chr17:80107153 G/C cg07393940 chr7:158741817 NA 0.37 6.64 0.34 1.25e-10 Life satisfaction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26443443 chr7:22396974 RAPGEF5 0.44 6.45 0.33 3.95e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4332037 0.539 rs56305291 chr7:2048706 A/G cg25206134 chr2:45395956 NA 0.62 7.22 0.37 3.54e-12 Bipolar disorder; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg11060661 chr22:24314208 DDT;DDTL 0.45 7.74 0.39 1.17e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs73198271 0.960 rs73198288 chr8:8613940 G/A cg15556689 chr8:8085844 FLJ10661 -0.51 -5.95 -0.31 6.85e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg06873352 chr17:61820015 STRADA 0.7 12.64 0.57 3.53e-30 Prudent dietary pattern; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg11965913 chr1:205819406 PM20D1 1.05 27.5 0.83 7.93e-88 Menarche (age at onset); LUSC cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs4722166 0.704 rs4321884 chr7:22741459 A/T cg26061582 chr7:22766209 IL6 0.39 5.87 0.31 1.02e-8 Lung cancer; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs11126339 chr2:26253223 T/C cg25036284 chr2:26402008 FAM59B -0.59 -8.1 -0.41 1.07e-14 Gut microbiome composition (summer); LUSC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg15704280 chr7:45808275 SEPT13 0.91 14.17 0.61 5.03e-36 Coronary artery disease; LUSC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg20821713 chr7:1055600 C7orf50 -0.57 -7.34 -0.37 1.68e-12 Bronchopulmonary dysplasia; LUSC cis rs77633900 0.772 rs157760 chr15:76800260 A/G cg21673338 chr15:77095150 SCAPER -0.71 -6.07 -0.32 3.44e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg15839431 chr19:19639596 YJEFN3 -0.56 -6.96 -0.36 1.85e-11 Bipolar disorder; LUSC cis rs10782582 0.522 rs12125933 chr1:76130920 C/T cg22875332 chr1:76189707 ACADM -0.42 -6.2 -0.32 1.64e-9 Daytime sleep phenotypes; LUSC cis rs6961069 0.777 rs1761667 chr7:80244939 G/A cg04458919 chr7:80252533 CD36 0.37 6.63 0.34 1.3100000000000001e-10 Platelet count; LUSC cis rs3008870 0.755 rs4655662 chr1:67416432 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.34 0.56 4.24e-29 Lymphocyte percentage of white cells; LUSC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg23262073 chr20:60523788 NA -0.63 -8.94 -0.44 2.75e-17 Obesity-related traits; LUSC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg17971929 chr21:40555470 PSMG1 0.73 11.94 0.55 1.28e-27 Cognitive function; LUSC cis rs2842992 0.747 rs4709378 chr6:160227435 G/C cg11366901 chr6:160182831 ACAT2 0.92 12.0 0.55 8.07e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg03709012 chr19:19516395 GATAD2A 0.87 14.79 0.63 1.95e-38 Tonsillectomy; LUSC cis rs6840360 0.615 rs4696096 chr4:152475387 A/G cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs6700559 0.740 rs4387211 chr1:200645938 A/T cg07804481 chr1:200639085 DDX59 -0.41 -5.8 -0.3 1.58e-8 Coronary artery disease; LUSC trans rs2275731 0.723 rs10904757 chr10:16548382 A/G cg00196167 chr7:139026058 C7orf55 -0.4 -6.06 -0.31 3.71e-9 Bone fracture in osteoporosis; LUSC cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.19 -0.45 4.31e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs57221529 0.766 rs12519763 chr5:559145 C/T cg08313168 chr12:7315531 NA 0.46 5.98 0.31 5.65e-9 Lung disease severity in cystic fibrosis; LUSC cis rs79976124 0.879 rs12213669 chr6:66627704 G/A cg07460842 chr6:66804631 NA 0.7 8.63 0.43 2.62e-16 Type 2 diabetes; LUSC cis rs1712517 0.787 rs1163089 chr10:105043964 G/A cg05636881 chr10:105038444 INA 0.38 6.28 0.32 1.06e-9 Migraine; LUSC cis rs2282300 0.637 rs10742240 chr11:30429438 A/G cg25418670 chr11:30344373 C11orf46 -0.41 -6.44 -0.33 4.08e-10 Morning vs. evening chronotype; LUSC cis rs8177253 0.633 rs10935073 chr3:133439184 T/C cg01448562 chr3:133502909 NA -0.52 -7.56 -0.38 3.94e-13 Iron status biomarkers; LUSC cis rs13315871 0.929 rs79813245 chr3:58318475 G/A cg12435725 chr3:58293450 RPP14 -0.75 -7.18 -0.37 4.6e-12 Cholesterol, total; LUSC trans rs7939886 0.920 rs7115395 chr11:55877116 G/A cg15704280 chr7:45808275 SEPT13 0.82 6.75 0.35 6.43e-11 Myopia (pathological); LUSC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.61 9.19 0.45 4.16e-18 Height; LUSC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg04287289 chr16:89883240 FANCA -0.42 -6.11 -0.32 2.74e-9 Vitiligo; LUSC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC cis rs55665837 1.000 rs11023223 chr11:14457112 A/G cg05501817 chr11:14380813 RRAS2 -0.41 -6.53 -0.34 2.5e-10 Vitamin D levels; LUSC cis rs36093844 0.752 rs113529766 chr11:85583401 G/A cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg18149561 chr19:13905866 ZSWIM4 0.38 6.21 0.32 1.6e-9 Asthma; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.69 -0.5 3.93e-23 Alzheimer's disease; LUSC cis rs709400 0.663 rs7145113 chr14:103945414 A/G cg10523860 chr14:103875565 MARK3 -0.39 -6.19 -0.32 1.77e-9 Body mass index; LUSC cis rs1003719 0.715 rs2835644 chr21:38545610 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs1577917 0.839 rs6454504 chr6:86580330 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs3771570 0.901 rs62190415 chr2:242426692 A/G cg21155796 chr2:242212141 HDLBP 0.53 6.01 0.31 4.88e-9 Prostate cancer; LUSC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg24829409 chr8:58192753 C8orf71 -0.61 -6.38 -0.33 6.05e-10 Developmental language disorder (linguistic errors); LUSC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg13531842 chr10:38383804 ZNF37A -0.47 -7.45 -0.38 8.06e-13 Extrinsic epigenetic age acceleration; LUSC cis rs4443100 0.832 rs4434089 chr22:23383863 A/G cg21100191 chr22:23484243 RTDR1 -0.47 -5.87 -0.31 1.04e-8 Serum parathyroid hormone levels; LUSC cis rs1018836 0.818 rs2285232 chr8:91546162 C/G cg16814680 chr8:91681699 NA -0.7 -11.21 -0.52 5.93e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs709400 0.628 rs11622320 chr14:103912194 A/T cg24130564 chr14:104152367 KLC1 -0.45 -6.22 -0.32 1.45e-9 Body mass index; LUSC trans rs9291683 0.588 rs2240722 chr4:10020757 A/G cg26043149 chr18:55253948 FECH 0.51 7.47 0.38 7.04e-13 Bone mineral density; LUSC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg16339924 chr4:17578868 LAP3 0.62 9.55 0.46 2.92e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg16339924 chr4:17578868 LAP3 0.58 8.68 0.43 1.74e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg21782813 chr7:2030301 MAD1L1 0.59 10.55 0.5 1.22e-22 Bipolar disorder and schizophrenia; LUSC cis rs9039 0.959 rs12925781 chr16:9216914 A/G cg08831531 chr16:9218945 NA 0.68 10.3 0.49 8.49e-22 Menopause (age at onset); LUSC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.51 -7.37 -0.37 1.32e-12 Mean platelet volume; LUSC trans rs11098499 0.865 rs3956464 chr4:120256764 T/C cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.34e-10 Corneal astigmatism; LUSC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg13683864 chr3:40499215 RPL14 -1.14 -19.9 -0.74 1.12e-58 Renal cell carcinoma; LUSC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.5 -0.33 2.99e-10 Coronary artery disease; LUSC cis rs6582630 0.539 rs8189604 chr12:38308546 G/T cg13010199 chr12:38710504 ALG10B -0.46 -6.92 -0.35 2.3e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs4891159 0.757 rs11665518 chr18:74147054 C/T cg24786174 chr18:74118243 ZNF516 -0.84 -15.63 -0.65 1.06e-41 Longevity; LUSC cis rs8062405 0.789 rs2106480 chr16:28537971 T/C cg16576597 chr16:28551801 NUPR1 0.29 5.81 0.3 1.44e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs8073060 0.586 rs225294 chr17:33925762 G/A cg19694781 chr19:47549865 TMEM160 -1.12 -17.91 -0.7 9.17e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs4332037 0.586 rs62442944 chr7:2015047 T/G cg10840412 chr1:235813424 GNG4 0.57 7.51 0.38 5.53e-13 Bipolar disorder; LUSC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs239198 0.602 rs11758174 chr6:101322595 G/A cg09795085 chr6:101329169 ASCC3 0.45 6.36 0.33 6.54e-10 Menarche (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06422146 chr16:70488547 FUK -0.44 -6.69 -0.34 9.59e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs400736 0.671 rs2131630 chr1:7990367 G/A cg25007680 chr1:8021821 PARK7 -0.47 -6.81 -0.35 4.69e-11 Response to antidepressants and depression; LUSC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg00343986 chr7:65444356 GUSB 0.47 7.04 0.36 1.08e-11 Calcium levels; LUSC trans rs6502050 0.835 rs4789738 chr17:80123053 G/A cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg17063962 chr7:91808500 NA 0.59 9.17 0.45 4.88e-18 Breast cancer; LUSC cis rs259282 0.605 rs8101920 chr19:33109270 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.65 9.59 0.46 2.07e-19 Schizophrenia; LUSC cis rs2594714 1.000 rs2607276 chr19:13954633 T/G cg18576835 chr19:13944261 NA -0.39 -5.67 -0.3 3.11e-8 Breast cancer; LUSC cis rs6674970 1.000 rs61819219 chr1:151084375 C/G cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.45 -6.03 -0.31 4.46e-9 Childhood ear infection; LUSC cis rs6977660 0.714 rs7798760 chr7:19803487 T/C cg07541023 chr7:19748670 TWISTNB 0.63 6.83 0.35 4.14e-11 Thyroid stimulating hormone; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.62 0.43 2.69e-16 Prudent dietary pattern; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23819836 chr6:15663134 DTNBP1 -0.52 -7.14 -0.36 5.84e-12 Bipolar disorder and schizophrenia; LUSC cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg27279351 chr12:120934652 DYNLL1 0.63 8.35 0.42 1.8e-15 High light scatter reticulocyte count; LUSC trans rs11098499 0.908 rs12504149 chr4:120318577 G/A cg25214090 chr10:38739885 LOC399744 0.54 7.82 0.39 6.86e-14 Corneal astigmatism; LUSC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg24324837 chr19:49891574 CCDC155 0.53 7.39 0.37 1.17e-12 Multiple sclerosis; LUSC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg19257562 chr1:2043853 PRKCZ 0.33 6.74 0.35 6.97e-11 Height; LUSC cis rs10779751 0.922 rs2295079 chr1:11322565 C/G cg08854313 chr1:11322531 MTOR 0.91 16.02 0.66 3.05e-43 Body mass index; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg26338869 chr17:61819248 STRADA 0.42 5.96 0.31 6.57e-9 Prudent dietary pattern; LUSC cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.31 -0.37 2.03e-12 Menopause (age at onset); LUSC cis rs4595586 0.545 rs2197941 chr12:39402223 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.99 0.31 5.41e-9 Morning vs. evening chronotype; LUSC cis rs11785400 0.793 rs11785012 chr8:143748355 G/A cg24634471 chr8:143751801 JRK 0.5 7.01 0.36 1.3e-11 Schizophrenia; LUSC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg11812906 chr14:75593930 NEK9 0.66 11.26 0.52 3.83e-25 Height; LUSC cis rs939658 0.805 rs4778924 chr15:79443363 T/C cg17916960 chr15:79447300 NA -0.53 -10.75 -0.51 2.33e-23 Refractive error; LUSC cis rs10754283 0.905 rs7519969 chr1:90108721 G/C cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -7.6 -0.38 2.98e-13 Chronic sinus infection; LUSC cis rs9653442 0.545 rs4490209 chr2:100766711 C/G cg22139774 chr2:100720529 AFF3 -0.41 -7.12 -0.36 6.73e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9378688 1.000 rs3823287 chr6:2244721 A/C cg12303981 chr6:2244766 GMDS -0.54 -6.99 -0.36 1.49e-11 Caudate nucleus volume; LUSC cis rs7759001 0.857 rs4711148 chr6:27360690 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.77e-8 Glomerular filtration rate (creatinine); LUSC trans rs12579753 0.879 rs10778828 chr12:82117216 C/A cg07923666 chr12:49932857 KCNH3 -0.5 -6.28 -0.32 1.06e-9 Resting heart rate; LUSC cis rs6964587 0.934 rs4512319 chr7:91733829 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.67 0.3 3.05e-8 Breast cancer; LUSC cis rs9443645 0.723 rs9343820 chr6:79480458 T/A cg05283184 chr6:79620031 NA -0.53 -10.02 -0.48 7.98e-21 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg02269571 chr22:50332266 NA 0.58 8.61 0.43 2.88e-16 Schizophrenia; LUSC cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg26384229 chr12:38710491 ALG10B 0.92 15.65 0.65 8.39e-42 Bladder cancer; LUSC cis rs4654899 0.680 rs4654874 chr1:21156667 C/T cg01072550 chr1:21505969 NA -0.47 -6.91 -0.35 2.5e-11 Superior frontal gyrus grey matter volume; LUSC cis rs2235544 0.565 rs72664114 chr1:54471747 C/T cg25741118 chr1:54482237 LDLRAD1 -0.28 -6.04 -0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.13 -0.32 2.41e-9 Life satisfaction; LUSC cis rs4268898 0.662 rs2303292 chr2:24432138 C/T cg06627628 chr2:24431161 ITSN2 -0.89 -13.28 -0.59 1.29e-32 Asthma; LUSC cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg08975724 chr8:8085496 FLJ10661 0.54 7.29 0.37 2.28e-12 Red cell distribution width; LUSC cis rs11122272 0.732 rs2808605 chr1:231540187 A/C cg06096015 chr1:231504339 EGLN1 0.56 9.73 0.47 7.59e-20 Hemoglobin concentration; LUSC trans rs208520 0.690 rs207102 chr6:66795671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC trans rs13196614 0.756 rs9485318 chr6:149019833 G/C cg01343097 chr1:248284971 OR2M1P 0.41 6.04 0.31 4e-9 Migraine; LUSC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg07701084 chr6:150067640 NUP43 0.57 8.73 0.43 1.28e-16 Lung cancer; LUSC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.14 -0.49 3.12e-21 Developmental language disorder (linguistic errors); LUSC cis rs2354432 0.556 rs7520661 chr1:146793149 A/G cg25205988 chr1:146714368 CHD1L -1.01 -9.21 -0.45 3.57e-18 Mitochondrial DNA levels; LUSC cis rs7584330 0.910 rs12465081 chr2:238401784 A/G cg16989719 chr2:238392110 NA -0.4 -6.78 -0.35 5.63e-11 Prostate cancer; LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.58 0.38 3.4e-13 Bipolar disorder; LUSC cis rs4423214 1.000 rs2002063 chr11:71163476 T/C cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg15448220 chr1:150897856 SETDB1 0.39 5.81 0.3 1.48e-8 Melanoma; LUSC cis rs868036 0.718 rs4776985 chr15:68123021 T/G cg24579218 chr15:68104479 NA -0.37 -6.59 -0.34 1.67e-10 Restless legs syndrome; LUSC cis rs7100689 0.646 rs9804233 chr10:82134667 T/C cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs17253792 0.822 rs76472022 chr14:56053660 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC trans rs853679 0.517 rs1947862 chr6:28105196 C/T cg06606381 chr12:133084897 FBRSL1 -0.45 -5.97 -0.31 6.07e-9 Depression; LUSC cis rs208520 0.526 rs9363522 chr6:66816642 C/T cg07460842 chr6:66804631 NA -1.24 -27.07 -0.83 3.27e-86 Exhaled nitric oxide output; LUSC cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg04398451 chr17:18023971 MYO15A 0.42 6.57 0.34 1.93e-10 Total body bone mineral density; LUSC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg24675658 chr1:53192096 ZYG11B 0.74 12.74 0.57 1.44e-30 Monocyte count; LUSC cis rs9341808 0.667 rs7746917 chr6:80931503 T/C cg08355045 chr6:80787529 NA 0.47 7.94 0.4 3.05e-14 Sitting height ratio; LUSC cis rs1614887 1 rs1614887 chr6:26393021 A/G cg09904177 chr6:26538194 HMGN4 0.51 7.63 0.39 2.43e-13 Intelligence (multi-trait analysis);Lobe attachment (rater-scored or self-reported); LUSC cis rs7582720 0.943 rs115130739 chr2:203725677 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10744422 1.000 rs937766 chr12:123331094 G/T cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.14e-12 Schizophrenia; LUSC cis rs9399135 0.967 rs7741515 chr6:135374368 C/G cg24558204 chr6:135376177 HBS1L -0.57 -8.8 -0.43 7.64e-17 Red blood cell count; LUSC cis rs7561273 0.565 rs6545275 chr2:24331860 A/G cg06627628 chr2:24431161 ITSN2 -0.52 -6.84 -0.35 3.89e-11 Quantitative traits; LUSC cis rs2354432 0.556 rs2353975 chr1:146837703 C/A cg25205988 chr1:146714368 CHD1L 0.85 7.57 0.38 3.76e-13 Mitochondrial DNA levels; LUSC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg25767906 chr1:53392781 SCP2 0.39 6.68 0.34 9.86e-11 Monocyte count; LUSC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg24110177 chr3:50126178 RBM5 0.57 9.61 0.47 1.89e-19 Intelligence (multi-trait analysis); LUSC cis rs12912251 1.000 rs71403553 chr15:38989121 C/A cg01338139 chr15:38987640 C15orf53 -0.5 -6.83 -0.35 3.95e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs3730682 0.694 rs565903 chr18:51777727 C/T cg04730925 chr18:51795821 POLI -0.45 -6.58 -0.34 1.79e-10 Psoriasis; LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg08470875 chr2:26401718 FAM59B 0.74 9.89 0.48 2.15e-20 Gut microbiome composition (summer); LUSC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.57 7.64 0.39 2.31e-13 Lung function (FEV1/FVC); LUSC cis rs16854884 1.000 rs34730687 chr3:143813193 A/G cg06585982 chr3:143692056 C3orf58 0.45 6.08 0.32 3.25e-9 Economic and political preferences (feminism/equality); LUSC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.69 0.5 3.96e-23 Schizophrenia; LUSC cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.48 6.87 0.35 3.2e-11 Monocyte percentage of white cells; LUSC cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg18252515 chr7:66147081 NA -0.58 -7.98 -0.4 2.44e-14 Corneal structure; LUSC cis rs1775715 0.707 rs1541261 chr10:32179523 G/A cg03015672 chr10:32216066 ARHGAP12 0.34 6.22 0.32 1.49e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg22166914 chr1:53195759 ZYG11B 0.48 7.55 0.38 4.22e-13 Monocyte count; LUSC cis rs73206853 0.764 rs59527539 chr12:110968119 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.51 0.38 5.31e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9837602 0.938 rs9815439 chr3:99785206 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.98 -0.31 5.74e-9 Breast cancer; LUSC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 9.96 0.48 1.24e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4919687 0.550 rs7904396 chr10:104456838 C/T cg05855489 chr10:104503620 C10orf26 0.68 10.88 0.51 8.65e-24 Colorectal cancer; LUSC cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.49e-8 Breast cancer; LUSC cis rs12980942 1.000 rs2241720 chr19:41829309 C/G cg25627403 chr19:41769009 HNRNPUL1 0.55 5.89 0.31 9.22e-9 Coronary artery disease; LUSC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg22532475 chr10:104410764 TRIM8 -0.34 -7.55 -0.38 4.16e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs12043259 0.892 rs35627019 chr1:204793461 T/C cg05134015 chr14:36973365 SFTA3 -0.5 -6.06 -0.31 3.75e-9 Addiction; LUSC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.53 -8.99 -0.44 1.93e-17 Multiple sclerosis; LUSC cis rs3741151 0.686 rs12277924 chr11:73219678 T/C cg17517138 chr11:73019481 ARHGEF17 0.77 7.26 0.37 2.7e-12 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg08213375 chr14:104286397 PPP1R13B -0.46 -8.49 -0.42 6.86e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.52 7.93 0.4 3.39e-14 Schizophrenia; LUSC cis rs1712517 0.525 rs2271751 chr10:105175131 A/G cg04362960 chr10:104952993 NT5C2 -0.49 -6.7 -0.34 8.63e-11 Migraine; LUSC cis rs7267979 0.868 rs6138553 chr20:25239233 G/A cg08601574 chr20:25228251 PYGB 0.47 7.3 0.37 2.12e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3784262 1.000 rs10851631 chr15:58242193 C/T cg12031962 chr15:58353849 ALDH1A2 -0.33 -6.04 -0.31 4.06e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg11764359 chr7:65958608 NA 0.68 10.89 0.51 7.94e-24 Aortic root size; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg07092213 chr7:1199455 ZFAND2A -0.43 -6.55 -0.34 2.2e-10 Longevity;Endometriosis; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg18758796 chr5:131593413 PDLIM4 0.51 8.54 0.42 4.99e-16 Acylcarnitine levels; LUSC cis rs6570726 1.000 rs1935615 chr6:145921117 G/T cg23711669 chr6:146136114 FBXO30 0.74 12.45 0.56 1.76e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs12908161 0.959 rs3748376 chr15:85328352 C/T cg17173187 chr15:85201210 NMB 0.47 8.61 0.43 3.02e-16 Schizophrenia; LUSC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg09267113 chr7:98030324 BAIAP2L1 0.39 6.0 0.31 5.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg24692254 chr21:30365293 RNF160 0.74 11.53 0.53 4.07e-26 Pancreatic cancer; LUSC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg15147215 chr3:52552868 STAB1 -0.31 -6.16 -0.32 2.1e-9 Intelligence (multi-trait analysis); LUSC cis rs7814319 0.933 rs13260865 chr8:97238472 A/T cg20787634 chr8:97240163 UQCRB -0.35 -6.02 -0.31 4.5e-9 Lung function (FVC); LUSC cis rs314370 0.904 rs13244629 chr7:100509253 A/C cg10426581 chr7:100472382 SRRT 0.85 12.39 0.56 2.91e-29 Resting heart rate; LUSC cis rs73206853 0.764 rs7312469 chr12:110889072 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9287719 0.935 rs10803723 chr2:10722877 C/T cg03983476 chr2:10830698 NOL10 -0.37 -5.66 -0.3 3.31e-8 Prostate cancer; LUSC cis rs9790314 0.586 rs16832246 chr3:161109916 A/G cg03342759 chr3:160939853 NMD3 0.43 6.35 0.33 7.09e-10 Morning vs. evening chronotype; LUSC cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg18721089 chr20:30220636 NA -0.37 -6.54 -0.34 2.35e-10 Mean corpuscular hemoglobin; LUSC cis rs9326248 0.581 rs4938331 chr11:116930682 C/A cg26566898 chr11:117069891 TAGLN 0.35 6.69 0.34 9.68e-11 Blood protein levels; LUSC cis rs6940638 0.688 rs1028308 chr6:27129757 G/A cg05738196 chr6:26577821 NA -0.48 -6.87 -0.35 3.13e-11 Intelligence (multi-trait analysis); LUSC cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg22467129 chr15:76604101 ETFA -0.43 -6.74 -0.35 7.13e-11 Blood metabolite levels; LUSC cis rs9911578 0.835 rs2301867 chr17:56480074 T/A cg05425664 chr17:57184151 TRIM37 0.55 8.57 0.42 3.81e-16 Intelligence (multi-trait analysis); LUSC cis rs1953600 0.837 rs2573352 chr10:81939813 T/C cg00277334 chr10:82204260 NA 0.45 7.08 0.36 8.43e-12 Sarcoidosis; LUSC cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs3007168 0.794 rs7156550 chr14:51620937 T/A cg23942311 chr14:51606299 NA -0.35 -6.67 -0.34 1.09e-10 Cancer; LUSC cis rs10876993 0.928 rs10877001 chr12:58083077 T/C cg15848620 chr12:58087721 OS9 0.56 8.08 0.4 1.2e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs7584330 0.666 rs72620816 chr2:238353604 C/T cg16989719 chr2:238392110 NA -0.42 -6.71 -0.34 8.46e-11 Prostate cancer; LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg06873352 chr17:61820015 STRADA 0.72 12.96 0.58 2.1e-31 Prudent dietary pattern; LUSC cis rs6700896 0.500 rs10889573 chr1:66129256 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10761482 0.813 rs7100985 chr10:62107166 G/A cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -12.22 -0.56 1.23e-28 Chronic sinus infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18954434 chr22:46692881 CN5H6.4;GTSE1 -0.41 -6.15 -0.32 2.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9300255 0.602 rs2682434 chr12:123694724 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg20302533 chr7:39170763 POU6F2 -0.54 -8.74 -0.43 1.14e-16 IgG glycosylation; LUSC cis rs5769765 0.955 rs5769767 chr22:50276909 G/A cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs7605378 0.964 rs2689763 chr2:200689555 G/A cg23649088 chr2:200775458 C2orf69 0.49 7.36 0.37 1.48e-12 Osteoporosis; LUSC cis rs3020736 0.500 rs4147638 chr22:42487900 G/A cg04733989 chr22:42467013 NAGA -0.62 -9.72 -0.47 7.81e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.81 14.6 0.62 1.14e-37 Total body bone mineral density; LUSC cis rs7615316 0.934 rs7651071 chr3:142243850 T/A cg16271453 chr3:142027066 XRN1 -0.39 -6.64 -0.34 1.27e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs11696501 0.688 rs6073855 chr20:44309670 C/T cg03272292 chr12:48577362 C12orf68 0.5 6.03 0.31 4.22e-9 Brain structure; LUSC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg05425664 chr17:57184151 TRIM37 0.58 8.88 0.44 4.12e-17 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg17541715 chr7:1216824 NA -0.37 -5.7 -0.3 2.57e-8 Longevity;Endometriosis; LUSC cis rs1775715 0.737 rs11008695 chr10:32216887 T/G cg03015672 chr10:32216066 ARHGAP12 0.33 5.94 0.31 7.06e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.4 0.42 1.32e-15 Schizophrenia; LUSC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg09835421 chr16:68378352 PRMT7 -0.54 -6.08 -0.32 3.32e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs1998174 0.509 rs10798701 chr1:171815431 G/A cg13482142 chr2:234261155 NA 0.41 6.03 0.31 4.32e-9 Platelet distribution width; LUSC cis rs7605827 0.930 rs1125533 chr2:15617751 C/G cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs4845570 1.000 rs3790514 chr1:151744168 T/C cg07092448 chr1:151763213 TDRKH -1.28 -14.57 -0.62 1.44e-37 Coronary artery disease; LUSC cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg00814883 chr7:100076585 TSC22D4 -0.77 -9.7 -0.47 9.35e-20 Platelet count; LUSC cis rs1044573 0.526 rs6050422 chr20:25177920 A/G cg08601574 chr20:25228251 PYGB 0.43 6.51 0.34 2.69e-10 Allergic rhinitis; LUSC cis rs61931739 0.517 rs56308002 chr12:34016021 C/G cg06521331 chr12:34319734 NA -0.47 -7.57 -0.38 3.58e-13 Morning vs. evening chronotype; LUSC cis rs12579753 0.917 rs7132732 chr12:82206053 C/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC trans rs7937682 0.961 rs11601674 chr11:111634354 C/T cg18187862 chr3:45730750 SACM1L 0.61 7.48 0.38 6.72e-13 Primary sclerosing cholangitis; LUSC cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg05347473 chr6:146136440 FBXO30 0.51 8.58 0.42 3.66e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs9393777 0.623 rs3734544 chr6:26468660 G/A cg12292205 chr6:26970375 C6orf41 -0.62 -7.36 -0.37 1.41e-12 Intelligence (multi-trait analysis); LUSC cis rs698813 0.642 rs1837702 chr2:44492444 T/A cg00619915 chr2:44497795 NA -0.52 -7.14 -0.36 5.75e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs3772130 0.583 rs58088236 chr3:121561765 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.82 13.45 0.59 3.06e-33 Cognitive performance; LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg25767906 chr1:53392781 SCP2 -0.52 -9.62 -0.47 1.73e-19 Monocyte count; LUSC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.29 -0.33 9.96e-10 Neuroticism; LUSC cis rs10493773 0.928 rs12741600 chr1:86191172 A/C cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.71 -0.47 8.49e-20 Urate levels in overweight individuals; LUSC cis rs35264875 1.000 rs6591370 chr11:68843003 G/A cg02660097 chr11:68866761 NA 0.43 6.09 0.32 3.16e-9 Blond vs. brown hair color; LUSC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg11663144 chr21:46675770 NA -0.41 -7.23 -0.37 3.33e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs17767294 0.708 rs72847370 chr6:27849424 A/T cg08851530 chr6:28072375 NA 1.18 7.77 0.39 9.45e-14 Parkinson's disease; LUSC trans rs10838798 0.504 rs11039673 chr11:48335156 G/A cg15704280 chr7:45808275 SEPT13 -0.45 -6.21 -0.32 1.55e-9 Height; LUSC cis rs6964587 0.967 rs28399886 chr7:91638451 A/G cg22709100 chr7:91322751 NA 0.41 6.07 0.32 3.44e-9 Breast cancer; LUSC cis rs7582180 0.629 rs4851296 chr2:100949570 T/C cg12002119 chr2:101014098 CHST10 0.35 5.85 0.31 1.14e-8 Intelligence (multi-trait analysis); LUSC cis rs11971779 0.680 rs7788777 chr7:139055193 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs3741404 0.512 rs4980504 chr11:63873083 G/A cg05555928 chr11:63887634 MACROD1 0.32 5.83 0.3 1.31e-8 Platelet count; LUSC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg11247378 chr22:39784982 NA -0.59 -11.39 -0.53 1.33e-25 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg05585544 chr11:47624801 NA -0.4 -7.02 -0.36 1.28e-11 Subjective well-being; LUSC trans rs4718428 0.960 rs6460317 chr7:66390255 A/G cg18876405 chr7:65276391 NA 0.47 7.38 0.37 1.23e-12 Corneal structure; LUSC cis rs9814567 0.896 rs58491661 chr3:134355189 G/T cg15484384 chr3:134203672 ANAPC13;CEP63 0.33 6.08 0.32 3.23e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs28595532 0.623 rs10016452 chr4:119277490 A/G cg26518628 chr1:97050305 NA -0.78 -6.07 -0.32 3.51e-9 Cannabis dependence symptom count; LUSC cis rs79976124 0.879 rs17432710 chr6:66621744 T/C cg07460842 chr6:66804631 NA 0.71 8.31 0.41 2.39e-15 Type 2 diabetes; LUSC cis rs7618501 1.000 rs3749240 chr3:49750188 T/A cg13072238 chr3:49761600 GMPPB -0.39 -6.36 -0.33 6.81e-10 Intelligence (multi-trait analysis); LUSC cis rs1538970 0.924 rs11211108 chr1:45891152 C/T cg05343316 chr1:45956843 TESK2 0.65 8.88 0.44 4.17e-17 Platelet count; LUSC cis rs1801251 0.963 rs35362030 chr2:233612845 A/G cg25237894 chr2:233734115 C2orf82 0.34 6.33 0.33 7.67e-10 Coronary artery disease; LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg00166722 chr3:10149974 C3orf24 0.64 9.13 0.45 6.76e-18 Alzheimer's disease; LUSC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs9646954 0.542 rs4149510 chr2:101023635 G/A cg08017756 chr2:100939284 LONRF2 -0.47 -8.86 -0.44 4.94e-17 Intelligence (multi-trait analysis); LUSC cis rs7824557 0.583 rs2263512 chr8:11233419 T/G cg21775007 chr8:11205619 TDH -0.68 -10.68 -0.5 4.35e-23 Retinal vascular caliber; LUSC cis rs2067615 0.524 rs10778505 chr12:107143126 G/C cg15890332 chr12:107067104 RFX4 0.35 6.33 0.33 8.09e-10 Heart rate; LUSC cis rs7927592 0.913 rs2282563 chr11:68333200 C/T cg20283391 chr11:68216788 NA -0.6 -8.4 -0.42 1.25e-15 Total body bone mineral density; LUSC cis rs17818399 0.547 rs12997164 chr2:46758746 A/C cg21681030 chr2:46777652 RHOQ 0.43 6.03 0.31 4.35e-9 Height; LUSC cis rs714027 0.605 rs4820830 chr22:30531091 C/T cg11564601 chr22:30592435 NA -0.33 -5.85 -0.3 1.2e-8 Lymphocyte counts; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg11843238 chr5:131593191 PDLIM4 -0.39 -6.37 -0.33 6.18e-10 Breast cancer; LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs9300255 0.679 rs4759420 chr12:123794871 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -5.77 -0.3 1.85e-8 Neutrophil percentage of white cells; LUSC cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg07741184 chr6:167504864 NA 0.36 6.53 0.34 2.47e-10 Crohn's disease; LUSC cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg14343924 chr8:8086146 FLJ10661 0.43 6.21 0.32 1.61e-9 Mood instability; LUSC cis rs2414856 0.510 rs72756985 chr15:64590694 T/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs3768617 0.811 rs12144261 chr1:183014148 A/G ch.1.3577855R chr1:183094577 LAMC1 0.6 8.59 0.43 3.46e-16 Fuchs's corneal dystrophy; LUSC cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg11266682 chr4:10021025 SLC2A9 0.57 10.46 0.5 2.43e-22 Bone mineral density; LUSC trans rs2204008 0.744 rs1115514 chr12:38280140 C/T cg06521331 chr12:34319734 NA -0.42 -6.55 -0.34 2.17e-10 Bladder cancer; LUSC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.61e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs3820928 0.934 rs66959645 chr2:227761582 C/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.72e-14 Pulmonary function; LUSC cis rs4786125 0.879 rs11640468 chr16:6895945 C/T cg03623568 chr16:6915990 A2BP1 -0.4 -6.65 -0.34 1.18e-10 Heart rate variability traits (SDNN); LUSC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg07701084 chr6:150067640 NUP43 -0.5 -7.52 -0.38 5.2e-13 Lung cancer; LUSC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg10792982 chr14:105748885 BRF1 0.48 8.93 0.44 2.87e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs9467711 0.651 rs16891264 chr6:26072445 C/T cg16898833 chr6:26189333 HIST1H4D -0.63 -5.71 -0.3 2.47e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7011049 1.000 rs11985687 chr8:53832602 G/A cg26025543 chr8:53854495 NA 0.51 6.25 0.32 1.25e-9 Systolic blood pressure; LUSC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg09165964 chr15:75287851 SCAMP5 -1.07 -16.47 -0.67 4.95e-45 Blood trace element (Zn levels); LUSC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg14552801 chr7:65878734 NA 0.45 6.43 0.33 4.5e-10 Aortic root size; LUSC cis rs6087771 0.682 rs2038397 chr20:30217759 A/G cg18721089 chr20:30220636 NA -0.34 -5.87 -0.31 1.06e-8 Subcortical brain region volumes;Putamen volume; LUSC cis rs9287719 0.967 rs2010073 chr2:10736478 C/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs6912958 0.712 rs2787927 chr6:88412786 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.76 -0.35 5.99e-11 Monocyte percentage of white cells; LUSC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg00343986 chr7:65444356 GUSB 0.43 6.54 0.34 2.29e-10 Aortic root size; LUSC cis rs11190604 1.000 rs12355721 chr10:102244911 C/T cg07080220 chr10:102295463 HIF1AN 0.63 8.37 0.42 1.64e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs782590 0.870 rs2586950 chr2:55868966 T/G cg03859395 chr2:55845619 SMEK2 0.82 14.43 0.62 4.94e-37 Metabolic syndrome; LUSC cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.05e-43 Bladder cancer; LUSC cis rs1200821 0.529 rs4934856 chr10:37807847 T/C cg25427524 chr10:38739819 LOC399744 0.39 6.42 0.33 4.8e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg05043794 chr9:111880884 C9orf5 -0.37 -7.9 -0.4 4.09e-14 Menarche (age at onset); LUSC cis rs250677 1.000 rs40525 chr5:148432932 G/T cg23229984 chr5:148520753 ABLIM3 -0.41 -6.58 -0.34 1.8e-10 Breast cancer; LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg21782813 chr7:2030301 MAD1L1 0.56 9.99 0.48 9.46e-21 Bipolar disorder and schizophrenia; LUSC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg18681998 chr4:17616180 MED28 0.89 17.28 0.69 2.88e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs897984 0.609 rs12445650 chr16:31044897 G/A cg02466173 chr16:30829666 NA -0.52 -10.2 -0.49 1.98e-21 Dementia with Lewy bodies; LUSC cis rs2070433 0.749 rs718496 chr21:47904585 A/C cg12379764 chr21:47803548 PCNT 0.68 9.13 0.45 6.45e-18 Lymphocyte counts; LUSC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg14895029 chr7:2775587 GNA12 -0.36 -5.71 -0.3 2.56e-8 Height; LUSC cis rs7512552 0.839 rs834231 chr1:150389392 A/T cg15654264 chr1:150340011 RPRD2 -0.61 -9.89 -0.48 2.11e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -6.44 -0.33 4.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg26513180 chr16:89883248 FANCA -0.88 -16.9 -0.68 9.89e-47 Vitiligo; LUSC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg10755058 chr3:40428713 ENTPD3 0.35 5.76 0.3 1.9e-8 Renal cell carcinoma; LUSC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg04248312 chr19:17393744 ANKLE1 -1.03 -17.11 -0.68 1.38e-47 Systemic lupus erythematosus; LUSC cis rs4629180 0.917 rs34217240 chr2:102136682 G/A cg01388757 chr2:102091195 RFX8 0.46 7.23 0.37 3.34e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs2637266 1.000 rs12783273 chr10:78353221 T/C cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs4919694 1.000 rs12258551 chr10:104767892 C/G cg23093090 chr10:104574429 C10orf26 -0.47 -5.76 -0.3 1.93e-8 Arsenic metabolism; LUSC cis rs1160297 0.609 rs1828336 chr2:53096937 G/T cg07782112 chr2:53107842 NA 0.43 7.0 0.36 1.42e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.69 -6.52 -0.34 2.67e-10 Cerebrospinal P-tau181p levels; LUSC cis rs801193 0.901 rs4273746 chr7:66301111 C/T cg12463550 chr7:65579703 CRCP -0.41 -5.84 -0.3 1.22e-8 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05206910 chr17:80230660 CSNK1D 0.39 6.04 0.31 4e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10779751 0.734 rs2039840 chr1:11125866 G/A cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg12011299 chr4:100065546 ADH4 0.71 10.85 0.51 1.08e-23 Smoking initiation; LUSC cis rs4654899 0.931 rs4654887 chr1:21234923 A/G cg01072550 chr1:21505969 NA 0.52 8.06 0.4 1.35e-14 Superior frontal gyrus grey matter volume; LUSC cis rs12190007 0.547 rs3006217 chr6:169862878 A/G ch.6.169577133F chr6:169835210 NA -0.4 -6.03 -0.31 4.35e-9 Obesity-related traits; LUSC cis rs9837602 1.000 rs6790535 chr3:99807735 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.74 -0.3 2.1e-8 Breast cancer; LUSC trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg03929089 chr4:120376271 NA 0.61 6.55 0.34 2.11e-10 D-dimer levels; LUSC cis rs1953600 0.754 rs2573348 chr10:81925785 C/T cg00277334 chr10:82204260 NA -0.44 -6.92 -0.35 2.36e-11 Sarcoidosis; LUSC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11890956 chr21:40555474 PSMG1 -0.92 -16.68 -0.67 7.22e-46 Cognitive function; LUSC cis rs2346177 0.542 rs13024414 chr2:46687062 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.59 -9.21 -0.45 3.62e-18 HDL cholesterol; LUSC cis rs1178968 1.000 rs757939 chr7:72778108 T/C cg25889504 chr7:72793014 NA 0.6 7.77 0.39 9.92e-14 Triglyceride levels; LUSC cis rs9905704 0.918 rs430973 chr17:56709206 T/G cg05425664 chr17:57184151 TRIM37 -0.42 -5.66 -0.3 3.22e-8 Testicular germ cell tumor; LUSC cis rs2425143 1.000 rs2425078 chr20:34298163 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.6 -0.34 1.6e-10 Blood protein levels; LUSC cis rs9443645 0.723 rs9343820 chr6:79480458 T/A cg09184832 chr6:79620586 NA -0.39 -5.89 -0.31 9.51e-9 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.806 rs9841371 chr3:134320765 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.39 -0.56 2.93e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg20821713 chr7:1055600 C7orf50 -0.56 -7.36 -0.37 1.45e-12 Bronchopulmonary dysplasia; LUSC cis rs6723108 0.651 rs6724866 chr2:135407310 C/A cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Type 2 diabetes; LUSC cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg24558204 chr6:135376177 HBS1L -0.61 -9.29 -0.45 2.02e-18 Red blood cell count; LUSC cis rs3815700 0.844 rs444089 chr19:33106991 G/C cg02997394 chr19:33096574 ANKRD27 0.83 8.89 0.44 3.93e-17 Eosinophilic esophagitis; LUSC cis rs12291225 0.585 rs11023194 chr11:14369769 T/C cg19336497 chr11:14380999 RRAS2 -0.61 -13.98 -0.61 2.7900000000000003e-35 Sense of smell; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24219704 chr12:107349641 C12orf23 -0.55 -6.36 -0.33 6.62e-10 Bipolar disorder and schizophrenia; LUSC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg16414030 chr3:133502952 NA -0.42 -6.55 -0.34 2.2e-10 Iron status biomarkers; LUSC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg15704280 chr7:45808275 SEPT13 1.0 16.98 0.68 4.6e-47 Coronary artery disease; LUSC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg18681998 chr4:17616180 MED28 0.84 15.39 0.64 9.38e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg24881330 chr22:46731750 TRMU 0.83 7.49 0.38 6.37e-13 LDL cholesterol;Cholesterol, total; LUSC trans rs7474896 0.507 rs2474555 chr10:38465220 G/C cg17830980 chr10:43048298 ZNF37B -0.52 -6.1 -0.32 2.96e-9 Obesity (extreme); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11636631 chr22:20428109 NA -0.46 -6.54 -0.34 2.29e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6464929 0.956 rs28463009 chr7:148708203 G/C cg23583168 chr7:148888333 NA 0.48 6.02 0.31 4.51e-9 Pediatric bone mineral content (hip); LUSC cis rs7106204 0.702 rs11826172 chr11:24233998 G/A ch.11.24196551F chr11:24239977 NA 1.17 14.77 0.63 2.35e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg23791538 chr6:167370224 RNASET2 0.41 6.69 0.34 9.3e-11 Crohn's disease; LUSC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg02187348 chr16:89574699 SPG7 0.59 9.47 0.46 5.16e-19 Multiple myeloma (IgH translocation); LUSC cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.11e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs853679 0.607 rs34662244 chr6:28073881 G/A cg01620082 chr3:125678407 NA -0.85 -7.28 -0.37 2.42e-12 Depression; LUSC cis rs748404 0.631 rs3809482 chr15:43661802 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.52 0.34 2.54e-10 Lung cancer; LUSC cis rs5758511 0.514 rs5758622 chr22:42563933 C/T cg00645731 chr22:42541494 CYP2D7P1 0.6 10.04 0.48 6.9299999999999992e-21 Birth weight; LUSC cis rs1775715 0.707 rs2808081 chr10:32162342 C/T cg18675610 chr10:32216311 ARHGAP12 -0.29 -6.32 -0.33 8.29e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11644478 chr21:40555479 PSMG1 -0.64 -9.82 -0.47 3.57e-20 Menarche (age at onset); LUSC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.25e-11 Tonsillectomy; LUSC cis rs72387598 1 rs72387598 chr1:45922977 CAT/C cg05343316 chr1:45956843 TESK2 0.67 8.96 0.44 2.29e-17 Platelet distribution width; LUSC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.85e-15 Homoarginine levels; LUSC cis rs7927771 0.524 rs10838763 chr11:47794802 C/T cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg19748678 chr4:122722346 EXOSC9 0.5 7.57 0.38 3.57e-13 Type 2 diabetes; LUSC cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg13298116 chr11:62369859 EML3;MTA2 0.52 7.86 0.4 5.19e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.54 -0.38 4.52e-13 Aortic root size; LUSC trans rs853679 0.607 rs34691223 chr6:28258208 C/A cg06606381 chr12:133084897 FBRSL1 -0.92 -8.91 -0.44 3.32e-17 Depression; LUSC cis rs7617773 0.963 rs6766754 chr3:48182589 T/C cg20734569 chr3:48348370 SPINK8 0.45 8.23 0.41 4.14e-15 Coronary artery disease; LUSC cis rs1172822 0.698 rs2384690 chr19:55828794 C/G cg04391588 chr19:55832610 TMEM150B 0.29 5.72 0.3 2.35e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs4589502 0.841 rs56401320 chr15:67140517 C/G cg12317470 chr15:67143691 NA 0.66 6.43 0.33 4.51e-10 Lung cancer (smoking interaction); LUSC cis rs6840360 0.509 rs62327273 chr4:152547594 A/G cg22705602 chr4:152727874 NA -0.33 -6.63 -0.34 1.3100000000000001e-10 Intelligence (multi-trait analysis); LUSC cis rs5758511 0.573 rs738248 chr22:42196467 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.4 -7.52 -0.38 4.99e-13 Birth weight; LUSC trans rs9329221 0.537 rs1351876 chr8:9984777 A/G cg21775007 chr8:11205619 TDH -0.45 -6.49 -0.33 3.14e-10 Neuroticism; LUSC cis rs4423214 0.879 rs1792281 chr11:71135496 G/A cg05163923 chr11:71159392 DHCR7 -0.66 -8.58 -0.42 3.63e-16 Vitamin D levels; LUSC cis rs9393777 0.623 rs9366658 chr6:26469866 G/A cg12292205 chr6:26970375 C6orf41 -0.63 -7.39 -0.37 1.23e-12 Intelligence (multi-trait analysis); LUSC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 0.48 8.02 0.4 1.79e-14 IgG glycosylation; LUSC cis rs6494488 0.500 rs72744719 chr15:65018928 T/C cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs35146811 0.657 rs36019559 chr7:99814586 A/G cg13334819 chr7:99746414 C7orf59 0.5 6.76 0.35 6e-11 Coronary artery disease; LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg14893161 chr1:205819251 PM20D1 0.5 7.41 0.38 1.01e-12 Prostate-specific antigen levels; LUSC cis rs11190604 0.673 rs10883498 chr10:102228709 T/A cg07080220 chr10:102295463 HIF1AN 0.64 8.53 0.42 5.05e-16 Palmitoleic acid (16:1n-7) levels; LUSC trans rs853679 1.000 rs1679732 chr6:28221264 G/A cg06606381 chr12:133084897 FBRSL1 0.58 6.7 0.34 9.02e-11 Depression; LUSC trans rs72674100 1.000 rs1987173 chr4:97973574 G/C cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9467711 0.651 rs71557316 chr6:26072981 G/A cg08501292 chr6:25962987 TRIM38 0.66 5.92 0.31 7.96e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs6460942 0.591 rs62451465 chr7:12364585 A/G cg06484146 chr7:12443880 VWDE -0.6 -6.44 -0.33 4.06e-10 Coronary artery disease; LUSC cis rs4474465 1.000 rs10899517 chr11:78180507 A/T cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.56 -0.34 2.01e-10 Electroencephalogram traits; LUSC cis rs6542838 0.611 rs7588441 chr2:99518858 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.36 -0.33 6.74e-10 Fear of minor pain; LUSC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg25456477 chr12:86230367 RASSF9 0.42 7.4 0.38 1.11e-12 Major depressive disorder; LUSC cis rs1670533 0.685 rs56019586 chr4:1059842 C/G cg27284194 chr4:1044797 NA 0.6 8.72 0.43 1.3e-16 Recombination rate (females); LUSC cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg15605315 chr1:45957053 TESK2 -0.42 -6.88 -0.35 2.96e-11 High light scatter reticulocyte count; LUSC cis rs2439831 0.867 rs4075674 chr15:43650230 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg16680214 chr1:154839983 KCNN3 -0.51 -9.7 -0.47 9.21e-20 Prostate cancer; LUSC cis rs7208859 0.623 rs56812022 chr17:29068733 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg09796270 chr17:17721594 SREBF1 0.43 7.57 0.38 3.78e-13 Total body bone mineral density; LUSC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg05347473 chr6:146136440 FBXO30 0.55 9.47 0.46 5.36e-19 Lobe attachment (rater-scored or self-reported); LUSC trans rs3857536 0.740 rs7769722 chr6:66891363 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC cis rs9467773 1.000 rs9986382 chr6:26550619 T/C cg11502198 chr6:26597334 ABT1 0.62 9.85 0.47 2.92e-20 Intelligence (multi-trait analysis); LUSC cis rs1018697 1.000 rs10786710 chr10:104548739 C/T cg04362960 chr10:104952993 NT5C2 0.47 6.47 0.33 3.54e-10 Colorectal adenoma (advanced); LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs4631830 0.720 rs2611471 chr10:51503559 G/C cg16070123 chr10:51489643 NA -0.56 -9.4 -0.46 9.02e-19 Prostate-specific antigen levels; LUSC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg18681998 chr4:17616180 MED28 0.84 15.65 0.65 8.27e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs41271473 1.000 rs6665334 chr1:228868574 A/C cg16512390 chr1:228756714 NA 0.5 5.98 0.31 5.73e-9 Chronic lymphocytic leukemia; LUSC trans rs61931739 0.534 rs1352206 chr12:34036668 G/A cg13010199 chr12:38710504 ALG10B 0.53 7.92 0.4 3.45e-14 Morning vs. evening chronotype; LUSC cis rs2230307 0.536 rs554742 chr1:100512568 G/A cg24955406 chr1:100503596 HIAT1 0.57 6.11 0.32 2.73e-9 Carotid intima media thickness; LUSC cis rs8062405 0.690 rs762634 chr16:28603335 T/C cg16576597 chr16:28551801 NUPR1 0.33 6.7 0.34 8.61e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10876993 0.749 rs703832 chr12:58024626 G/C cg15848620 chr12:58087721 OS9 -0.48 -6.54 -0.34 2.26e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs9788721 0.902 rs7180002 chr15:78873993 A/T cg18825076 chr15:78729989 IREB2 -0.5 -7.77 -0.39 9.89e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.86 -12.5 -0.56 1.16e-29 Platelet count; LUSC cis rs7568458 0.905 rs6739015 chr2:85755357 A/G cg23752985 chr2:85803571 VAMP8 0.33 7.06 0.36 9.49e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg06740227 chr12:86229804 RASSF9 -0.37 -5.86 -0.31 1.12e-8 Major depressive disorder; LUSC cis rs73206853 0.764 rs56179460 chr12:111125774 C/G cg12870014 chr12:110450643 ANKRD13A 0.68 6.52 0.34 2.55e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg17554472 chr22:41940697 POLR3H 0.48 5.95 0.31 6.68e-9 Vitiligo; LUSC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg22437258 chr11:111473054 SIK2 0.46 6.12 0.32 2.63e-9 Primary sclerosing cholangitis; LUSC cis rs62458065 0.513 rs787220 chr7:32581139 C/G cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.98 -0.31 5.87e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9283706 0.608 rs1428407 chr5:66330416 C/T cg11590213 chr5:66331682 MAST4 0.47 6.85 0.35 3.64e-11 Coronary artery disease; LUSC cis rs67366981 0.800 rs55939042 chr14:77691186 T/A cg22824376 chr14:77648248 TMEM63C 0.76 7.15 0.36 5.64e-12 Obsessive-compulsive symptoms; LUSC cis rs6901250 0.851 rs168128 chr6:117166865 A/G cg12892004 chr6:117198278 RFX6 -0.44 -8.44 -0.42 9.93e-16 C-reactive protein levels; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg07677032 chr17:61819896 STRADA 0.57 9.3 0.45 1.9e-18 Prudent dietary pattern; LUSC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.6 9.18 0.45 4.72e-18 Total body bone mineral density; LUSC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg10018233 chr7:150070692 REPIN1 0.38 6.25 0.32 1.26e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6942756 0.806 rs6467240 chr7:128984018 T/C cg02491457 chr7:128862824 NA -0.51 -7.63 -0.39 2.46e-13 White matter hyperintensity burden; LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg16405210 chr4:1374714 KIAA1530 -0.55 -8.61 -0.43 2.99e-16 Obesity-related traits; LUSC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg23630131 chr7:65973040 NA -0.2 -5.68 -0.3 2.97e-8 Aortic root size; LUSC cis rs12579753 1.000 rs10862371 chr12:82249298 C/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.86 -0.31 1.11e-8 Resting heart rate; LUSC cis rs10089 0.951 rs1864923 chr5:127420843 G/C cg19767477 chr5:127420684 SLC12A2 -0.42 -5.83 -0.3 1.33e-8 Ileal carcinoids; LUSC trans rs7726839 0.540 rs72703095 chr5:601789 T/C cg11887960 chr12:57824829 NA 0.54 6.7 0.34 8.71e-11 Obesity-related traits; LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs9303280 0.901 rs8067378 chr17:38051348 A/G cg10909506 chr17:38081995 ORMDL3 0.33 5.83 0.3 1.28e-8 Self-reported allergy; LUSC trans rs7615952 0.604 rs9837847 chr3:125623919 G/A cg07211511 chr3:129823064 LOC729375 -1.02 -12.7 -0.57 2.08e-30 Blood pressure (smoking interaction); LUSC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg00033643 chr7:134001901 SLC35B4 0.44 6.83 0.35 4.02e-11 Mean platelet volume; LUSC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg22963979 chr7:1858916 MAD1L1 -0.54 -8.02 -0.4 1.84e-14 Bipolar disorder and schizophrenia; LUSC cis rs6840360 0.593 rs11723227 chr4:152689717 G/A cg22705602 chr4:152727874 NA -0.39 -8.3 -0.41 2.54e-15 Intelligence (multi-trait analysis); LUSC cis rs7208859 0.623 rs9911997 chr17:29124648 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs708547 0.957 rs781667 chr4:57798469 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -6.0 -0.31 5.25e-9 Response to bleomycin (chromatid breaks); LUSC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg07636037 chr3:49044803 WDR6 1.02 17.4 0.69 1e-48 Parkinson's disease; LUSC cis rs12618769 0.625 rs3769736 chr2:99089119 C/T cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs6712932 0.962 rs10496390 chr2:105838791 C/T cg22878388 chr2:105853796 NA -0.33 -6.37 -0.33 6.25e-10 Type 2 diabetes; LUSC cis rs17270561 0.553 rs6456696 chr6:25741408 A/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg02782426 chr3:40428986 ENTPD3 0.32 6.31 0.33 8.92e-10 Renal cell carcinoma; LUSC trans rs9473924 1.000 rs6922746 chr6:50889828 A/T cg22375689 chr19:34175036 CHST8 0.38 6.15 0.32 2.2e-9 Body mass index; LUSC cis rs1577917 1.000 rs11758849 chr6:86708262 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -9.09 -0.45 9.13e-18 Response to antipsychotic treatment; LUSC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg18230493 chr5:56204884 C5orf35 -0.64 -10.18 -0.49 2.32e-21 Coronary artery disease; LUSC cis rs73110464 0.505 rs2638503 chr12:53307369 C/G cg10046767 chr12:53297693 KRT8 0.46 6.35 0.33 6.84e-10 Cancer (pleiotropy); LUSC cis rs7481584 0.581 rs406598 chr11:3076285 G/A cg25174290 chr11:3078921 CARS -0.4 -5.84 -0.3 1.22e-8 Calcium levels; LUSC cis rs67311347 1.000 rs9842564 chr3:40405810 A/G cg24209194 chr3:40518798 ZNF619 -0.42 -5.72 -0.3 2.4e-8 Renal cell carcinoma; LUSC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg18827107 chr12:86230957 RASSF9 -0.42 -6.08 -0.32 3.35e-9 Major depressive disorder; LUSC cis rs2806561 0.765 rs9426692 chr1:23508426 C/T cg19743168 chr1:23544995 NA 0.41 7.96 0.4 2.75e-14 Height; LUSC cis rs1395 0.744 rs11126931 chr2:27474306 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 6.81 0.35 4.47e-11 Blood metabolite levels; LUSC trans rs7681440 0.904 rs7698219 chr4:90771351 C/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.97 -0.31 6.18e-9 Dementia with Lewy bodies; LUSC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.41 0.33 4.97e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2797685 0.898 rs2071987 chr1:7834026 G/A cg04725166 chr1:7887271 PER3 -0.49 -6.47 -0.33 3.5e-10 Crohn's disease; LUSC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg03676636 chr4:99064102 C4orf37 0.36 7.99 0.4 2.18e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg18135555 chr8:22132992 PIWIL2 0.4 8.09 0.4 1.14e-14 Hypertriglyceridemia; LUSC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg00857998 chr1:205179979 DSTYK 0.64 9.83 0.47 3.41e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7607369 0.559 rs4674342 chr2:219660064 T/C cg02176678 chr2:219576539 TTLL4 -0.54 -9.62 -0.47 1.72e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs9473147 0.516 rs1485780 chr6:47556630 A/C cg02130027 chr6:47444894 CD2AP 0.35 5.7 0.3 2.68e-8 Platelet distribution width;Mean platelet volume; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg16575590 chr16:90015019 DEF8 0.39 6.1 0.32 2.98e-9 Schizophrenia; LUSC cis rs3845702 0.668 rs6759271 chr2:180844303 T/C cg01881094 chr2:180872142 CWC22 -1.06 -12.75 -0.57 1.28e-30 Schizophrenia; LUSC cis rs1395 0.922 rs4665376 chr2:27509032 T/C cg23587288 chr2:27483067 SLC30A3 -0.3 -5.76 -0.3 1.9e-8 Blood metabolite levels; LUSC cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg13535736 chr9:111863775 C9orf5 -0.39 -6.33 -0.33 7.7e-10 Menarche (age at onset); LUSC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg19318889 chr4:1322082 MAEA 0.45 7.28 0.37 2.42e-12 Obesity-related traits; LUSC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg03517284 chr6:25882590 NA -0.42 -7.13 -0.36 6.32e-12 Intelligence (multi-trait analysis); LUSC cis rs6940638 1.000 rs12215773 chr6:27039233 T/C cg09904177 chr6:26538194 HMGN4 -0.51 -5.91 -0.31 8.36e-9 Intelligence (multi-trait analysis); LUSC trans rs6951245 1.000 rs76804143 chr7:1082021 C/T cg13565492 chr6:43139072 SRF -0.56 -6.01 -0.31 4.81e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg13175981 chr1:150552382 MCL1 0.52 7.37 0.37 1.32e-12 Tonsillectomy; LUSC cis rs11048434 0.736 rs35870866 chr12:9129091 C/A cg13575925 chr12:9217583 LOC144571 0.34 6.42 0.33 4.59e-10 Sjögren's syndrome; LUSC cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg09307838 chr4:120376055 NA 0.78 11.54 0.53 3.86e-26 Corneal astigmatism; LUSC trans rs561341 1.000 rs55959993 chr17:30254771 C/G cg20587970 chr11:113659929 NA -1.27 -17.35 -0.69 1.62e-48 Hip circumference adjusted for BMI; LUSC cis rs2688608 0.933 rs2688614 chr10:75652876 G/A cg17411546 chr10:75410026 SYNPO2L -0.47 -6.86 -0.35 3.41e-11 Inflammatory bowel disease; LUSC cis rs16867321 0.853 rs73023563 chr2:181502830 C/T cg23363182 chr2:181467187 NA -0.45 -5.92 -0.31 7.98e-9 Obesity; LUSC cis rs1008375 1.000 rs11947857 chr4:17691047 T/C cg16339924 chr4:17578868 LAP3 -0.55 -8.12 -0.41 9.25e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg21951975 chr1:209979733 IRF6 0.57 6.87 0.35 3.14e-11 Cleft lip with or without cleft palate; LUSC cis rs600231 0.708 rs661403 chr11:65242478 A/G cg21890820 chr11:65308645 LTBP3 0.49 7.16 0.36 5.14e-12 Bone mineral density; LUSC cis rs9638182 0.636 rs6968170 chr7:73020676 G/A cg07452164 chr7:72993570 TBL2 0.49 6.91 0.35 2.52e-11 Triglycerides; LUSC cis rs9399401 0.921 rs4637667 chr6:142794021 C/A cg03128060 chr6:142623767 GPR126 0.33 5.87 0.31 1.03e-8 Chronic obstructive pulmonary disease; LUSC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.48 6.87 0.35 3.15e-11 Bipolar disorder; LUSC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg03060546 chr3:49711283 APEH -0.7 -11.65 -0.54 1.46e-26 Resting heart rate; LUSC cis rs34779708 0.931 rs12248333 chr10:35362977 A/G cg03585969 chr10:35415529 CREM 0.6 8.8 0.43 7.41e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9677476 0.863 rs4637098 chr2:232075528 C/T cg07929768 chr2:232055508 NA 0.35 6.78 0.35 5.58e-11 Food antigen IgG levels; LUSC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg16049864 chr8:95962084 TP53INP1 0.46 7.83 0.39 6.64e-14 Type 2 diabetes; LUSC trans rs2243480 1.000 rs13235972 chr7:65883605 C/T cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC cis rs909341 0.710 rs3848669 chr20:62300811 G/T cg16989086 chr20:62203971 PRIC285 -0.53 -7.34 -0.37 1.62e-12 Atopic dermatitis; LUSC cis rs9611519 0.894 rs9611488 chr22:41462592 G/T cg03806693 chr22:41940476 POLR3H -0.55 -7.46 -0.38 7.78e-13 Neuroticism; LUSC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg01097406 chr16:89675127 NA 0.47 9.61 0.47 1.83e-19 Vitiligo; LUSC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 6.28 0.33 1.04e-9 Parkinson's disease; LUSC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -7.87 -0.4 5.01e-14 Major depressive disorder; LUSC trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg03929089 chr4:120376271 NA 0.7 7.63 0.39 2.43e-13 Axial length; LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.16 0.45 5.42e-18 Prudent dietary pattern; LUSC cis rs9527 0.569 rs10786730 chr10:104724200 G/A cg05855489 chr10:104503620 C10orf26 0.53 8.09 0.4 1.1e-14 Arsenic metabolism; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg08088566 chr11:430123 ANO9 0.72 7.77 0.39 9.65e-14 Body mass index; LUSC cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs4853525 0.859 rs11897136 chr2:191711080 C/T cg11845111 chr2:191398756 TMEM194B -0.39 -5.87 -0.31 1.07e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06285766 chr7:77167210 PTPN12 -0.42 -6.35 -0.33 7.03e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2439831 0.850 rs9944216 chr15:44160773 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.92 -9.02 -0.44 1.5e-17 Lung cancer in ever smokers; LUSC cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.65 0.86 4.24e-99 Chronic sinus infection; LUSC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.31 -0.33 9.03e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs2486288 0.656 rs12910009 chr15:45572408 A/G cg09092052 chr15:45571596 NA 0.46 6.34 0.33 7.51e-10 Glomerular filtration rate; LUSC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg08470875 chr2:26401718 FAM59B -0.66 -8.71 -0.43 1.42e-16 Gut microbiome composition (summer); LUSC trans rs72674100 1.000 rs28457587 chr4:97991521 T/C cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -6.98 -0.36 1.64e-11 Bipolar disorder; LUSC cis rs9467711 0.651 rs66790453 chr6:26107088 C/T cg08501292 chr6:25962987 TRIM38 0.65 5.85 0.31 1.15e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg04267008 chr7:1944627 MAD1L1 -0.44 -6.52 -0.34 2.58e-10 Bipolar disorder and schizophrenia; LUSC trans rs2832077 0.824 rs4816333 chr21:30201777 C/G cg14791747 chr16:20752902 THUMPD1 0.72 9.58 0.46 2.35e-19 Cognitive test performance; LUSC cis rs847577 0.630 rs13221758 chr7:97719806 A/C cg24562669 chr7:97807699 LMTK2 0.47 8.39 0.42 1.41e-15 Breast cancer; LUSC trans rs3733585 0.673 rs4495037 chr4:9954050 C/G cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs116988415 0.584 rs4899145 chr14:65241867 G/A cg25083366 chr14:65239357 SPTB 0.66 6.37 0.33 6.41e-10 Daytime sleep phenotypes; LUSC cis rs686320 1.000 rs1194758 chr11:65238085 A/T cg21890820 chr11:65308645 LTBP3 -0.74 -7.64 -0.39 2.26e-13 Hip circumference adjusted for BMI; LUSC cis rs3858526 0.834 rs10769395 chr11:5979620 G/A cg25319279 chr11:5960081 NA -0.45 -6.33 -0.33 7.89e-10 DNA methylation (variation); LUSC cis rs11958404 0.932 rs72816598 chr5:157436017 G/A cg05962755 chr5:157440814 NA 0.53 6.3 0.33 9.34e-10 IgG glycosylation; LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg27535305 chr1:53392650 SCP2 -0.39 -7.36 -0.37 1.43e-12 Monocyte count; LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs7582180 0.677 rs11694723 chr2:100878122 C/T cg08017756 chr2:100939284 LONRF2 -0.38 -6.58 -0.34 1.8e-10 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.876 rs1582127 chr6:86697204 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.16 -0.32 2.06e-9 Response to antipsychotic treatment; LUSC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg00049323 chr5:472564 LOC25845 -0.41 -6.15 -0.32 2.17e-9 Cystic fibrosis severity; LUSC cis rs17253792 0.822 rs10483650 chr14:56145312 A/G cg01858014 chr14:56050164 KTN1 -0.79 -6.72 -0.35 7.8e-11 Putamen volume; LUSC cis rs7712401 0.562 rs401729 chr5:122264285 G/T cg19077854 chr5:122220652 SNX24 0.41 8.93 0.44 2.84e-17 Mean platelet volume; LUSC cis rs73206853 0.841 rs73206870 chr12:110819953 T/C cg12870014 chr12:110450643 ANKRD13A 0.67 6.46 0.33 3.72e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10754283 0.967 rs7552896 chr1:90103194 A/G cg21401794 chr1:90099060 LRRC8C 0.65 9.85 0.47 3.02e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9549367 0.762 rs9549694 chr13:113870510 G/A cg00898013 chr13:113819073 PROZ -0.59 -8.79 -0.43 8.06e-17 Platelet distribution width; LUSC cis rs10465746 1.000 rs10465746 chr1:84387632 T/G cg10977910 chr1:84465055 TTLL7 0.43 6.35 0.33 7.05e-10 Obesity-related traits; LUSC cis rs73206853 0.764 rs56273026 chr12:110901691 A/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg17366294 chr4:99064904 C4orf37 -0.56 -10.11 -0.48 3.97e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs16854884 0.657 rs35193361 chr3:143716420 A/G cg06585982 chr3:143692056 C3orf58 0.45 6.73 0.35 7.59e-11 Economic and political preferences (feminism/equality); LUSC trans rs208515 0.525 rs10755508 chr6:66675790 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.01 13.77 0.6 1.75e-34 Exhaled nitric oxide levels; LUSC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg11812906 chr14:75593930 NEK9 -0.62 -10.45 -0.5 2.6e-22 Height; LUSC cis rs9297145 0.678 rs62473048 chr7:98775511 T/C cg05967295 chr7:98741636 SMURF1 0.96 14.34 0.62 1.14e-36 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs950169 0.541 rs10795 chr15:85177297 G/A cg17173187 chr15:85201210 NMB 0.46 8.73 0.43 1.26e-16 Schizophrenia; LUSC cis rs1124376 1.000 rs17006623 chr3:20161043 G/T cg05072819 chr3:20081367 KAT2B 0.56 6.26 0.32 1.19e-9 Bipolar disorder and schizophrenia; LUSC trans rs2243480 0.901 rs73148097 chr7:65431787 A/C cg10756647 chr7:56101905 PSPH 0.86 8.36 0.42 1.7e-15 Diabetic kidney disease; LUSC trans rs17783634 0.509 rs11775489 chr8:11036843 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.0 -0.36 1.39e-11 Subjective well-being; LUSC cis rs12618769 0.652 rs3754878 chr2:99179384 G/A cg10123293 chr2:99228465 UNC50 0.47 7.44 0.38 8.51e-13 Bipolar disorder; LUSC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg06212747 chr3:49208901 KLHDC8B 0.43 5.86 0.31 1.1e-8 Parkinson's disease; LUSC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11644478 chr21:40555479 PSMG1 0.92 17.99 0.7 4.46e-51 Cognitive function; LUSC cis rs6906287 0.647 rs59671368 chr6:118911430 T/A cg21191810 chr6:118973309 C6orf204 0.32 5.96 0.31 6.47e-9 Electrocardiographic conduction measures; LUSC trans rs1499614 0.803 rs1922723 chr7:66175063 C/T cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs422249 0.547 rs102275 chr11:61557803 T/C cg19610905 chr11:61596333 FADS2 -0.54 -8.34 -0.42 1.98e-15 Trans fatty acid levels; LUSC cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg06064525 chr11:970664 AP2A2 -0.35 -7.12 -0.36 6.46e-12 Alzheimer's disease (late onset); LUSC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg05623727 chr3:50126028 RBM5 -0.31 -5.86 -0.31 1.09e-8 Intelligence (multi-trait analysis); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg24625240 chr11:126081434 RPUSD4;FAM118B 0.5 6.2 0.32 1.7e-9 Cognitive function;Information processing speed; LUSC cis rs2408955 0.522 rs4760612 chr12:48421856 C/T cg24011408 chr12:48396354 COL2A1 -0.4 -5.78 -0.3 1.67e-8 Glycated hemoglobin levels; LUSC cis rs68170813 0.562 rs11770061 chr7:107071310 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.44 -5.68 -0.3 2.95e-8 Coronary artery disease; LUSC cis rs1577917 0.876 rs4618490 chr6:86518403 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.83 -0.43 6.08e-17 Response to antipsychotic treatment; LUSC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg19920283 chr7:105172520 RINT1 0.57 6.08 0.32 3.34e-9 Bipolar disorder (body mass index interaction); LUSC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg11812906 chr14:75593930 NEK9 0.66 11.26 0.52 3.87e-25 Height; LUSC cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg22532475 chr10:104410764 TRIM8 -0.38 -8.19 -0.41 5.55e-15 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7945705 0.776 rs11042069 chr11:8817315 G/A cg12365402 chr11:9010492 NRIP3 0.44 7.63 0.39 2.51e-13 Hemoglobin concentration; LUSC trans rs656319 0.559 rs17689289 chr8:9977980 C/G cg15556689 chr8:8085844 FLJ10661 0.48 7.0 0.36 1.39e-11 Myopia (pathological); LUSC cis rs870825 0.860 rs28799091 chr4:185598594 G/A cg04058563 chr4:185651563 MLF1IP 0.84 12.67 0.57 2.58e-30 Blood protein levels; LUSC cis rs1143633 0.615 rs11687403 chr2:113643638 G/A cg06156847 chr2:113672199 IL1F7 0.28 5.83 0.3 1.34e-8 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6087771 0.890 rs6089056 chr20:30325773 A/G cg13852791 chr20:30311386 BCL2L1 0.95 14.9 0.63 7.51e-39 Subcortical brain region volumes;Putamen volume; LUSC cis rs3772130 0.962 rs6789736 chr3:121543084 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.24 0.49 1.44e-21 Cognitive performance; LUSC cis rs6977660 0.714 rs9969381 chr7:19827454 C/T cg07541023 chr7:19748670 TWISTNB 0.59 6.01 0.31 4.9e-9 Thyroid stimulating hormone; LUSC cis rs9329289 0.590 rs11251295 chr10:2563183 C/T cg05625103 chr10:2543513 NA 0.39 5.65 0.3 3.52e-8 Age-related hearing impairment; LUSC cis rs9300255 0.770 rs7980687 chr12:123822711 G/A cg00376283 chr12:123451042 ABCB9 -0.64 -7.38 -0.37 1.27e-12 Neutrophil percentage of white cells; LUSC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg24558204 chr6:135376177 HBS1L 0.57 8.37 0.42 1.63e-15 Red blood cell count; LUSC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg01802117 chr1:53393560 SCP2 0.39 6.37 0.33 6.36e-10 Monocyte count; LUSC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg11812906 chr14:75593930 NEK9 -0.54 -8.74 -0.43 1.16e-16 Coronary artery disease; LUSC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg06238570 chr21:40685208 BRWD1 0.48 7.49 0.38 6.36e-13 Cognitive function; LUSC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.06 0.31 3.63e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.23 0.45 3.14e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg04352962 chr1:209979756 IRF6 0.56 6.63 0.34 1.35e-10 Cleft lip with or without cleft palate; LUSC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.52 -0.42 5.59e-16 Personality dimensions; LUSC cis rs7681440 0.647 rs11941682 chr4:90804316 T/G cg20003494 chr4:90757398 SNCA -0.36 -5.99 -0.31 5.54e-9 Dementia with Lewy bodies; LUSC trans rs1459104 0.714 rs35789111 chr11:54926634 C/G cg03929089 chr4:120376271 NA 0.74 6.24 0.32 1.36e-9 Body mass index; LUSC cis rs6469656 1.000 rs6980504 chr8:117680269 T/C cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs7527798 0.592 rs6657161 chr1:207847128 C/T cg09232269 chr1:207846808 CR1L -0.29 -6.23 -0.32 1.37e-9 Erythrocyte sedimentation rate; LUSC cis rs3812111 0.510 rs1931892 chr6:116594511 A/C cg18828861 chr6:116576566 TSPYL4 0.38 6.78 0.35 5.48e-11 Age-related macular degeneration; LUSC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg19318889 chr4:1322082 MAEA 0.58 10.04 0.48 6.88e-21 Longevity; LUSC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.57 7.32 0.37 1.83e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.59 -0.38 3.23e-13 Height; LUSC cis rs9650315 0.929 rs35093016 chr8:57161412 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.07 0.36 9.07e-12 Height; LUSC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg13770153 chr20:60521292 NA -0.61 -8.19 -0.41 5.59e-15 Body mass index; LUSC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg14552801 chr7:65878734 NA 0.38 5.9 0.31 8.97e-9 Aortic root size; LUSC cis rs2348418 0.864 rs7968563 chr12:28716777 T/C cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg02228329 chr11:64053129 BAD;GPR137 0.52 7.71 0.39 1.48e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs10752881 1.000 rs10797812 chr1:182984597 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.6 -9.13 -0.45 6.57e-18 Colorectal cancer; LUSC cis rs4478137 0.931 rs7665672 chr4:164236875 G/A cg06758707 chr4:164254230 NPY1R 0.63 9.93 0.48 1.52e-20 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7804356 1.000 rs3801805 chr7:26897640 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.23 -0.32 1.41e-9 Type 1 diabetes; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg13397359 chr6:42928475 GNMT 0.58 9.78 0.47 4.8e-20 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs877282 0.898 rs12357995 chr10:765739 T/C cg17470449 chr10:769945 NA 0.53 7.09 0.36 8.21e-12 Uric acid levels; LUSC cis rs208520 0.609 rs208436 chr6:66897470 G/A cg07460842 chr6:66804631 NA -0.8 -11.57 -0.53 3.01e-26 Exhaled nitric oxide output; LUSC cis rs6942756 0.680 rs691555 chr7:129135770 C/T cg02491457 chr7:128862824 NA -0.38 -5.71 -0.3 2.47e-8 White matter hyperintensity burden; LUSC cis rs9611565 0.729 rs12165508 chr22:41819960 T/C cg03806693 chr22:41940476 POLR3H 0.87 12.52 0.57 9.53e-30 Vitiligo; LUSC cis rs1018836 0.892 rs5005585 chr8:91581975 A/G cg16814680 chr8:91681699 NA -0.68 -10.62 -0.5 6.91e-23 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs16854884 0.657 rs62269895 chr3:143749085 C/G cg06585982 chr3:143692056 C3orf58 0.5 7.81 0.39 7.3e-14 Economic and political preferences (feminism/equality); LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg11062466 chr8:58055876 NA -0.68 -9.08 -0.45 9.4e-18 Developmental language disorder (linguistic errors); LUSC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.94 0.4 3.02e-14 Parkinson's disease; LUSC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs735539 0.645 rs7995773 chr13:21251235 T/C cg04906043 chr13:21280425 IL17D -0.46 -7.58 -0.38 3.41e-13 Dental caries; LUSC cis rs6500602 0.702 rs9929475 chr16:4540885 C/T cg08645402 chr16:4508243 NA -0.42 -7.06 -0.36 9.91e-12 Schizophrenia; LUSC cis rs3099143 1.000 rs2063542 chr15:77149498 A/G cg21673338 chr15:77095150 SCAPER -0.81 -7.57 -0.38 3.61e-13 Recalcitrant atopic dermatitis; LUSC cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg20476274 chr7:133979776 SLC35B4 -0.77 -13.01 -0.58 1.39e-31 Mean platelet volume; LUSC trans rs61931739 0.500 rs11053249 chr12:34518834 A/T cg13010199 chr12:38710504 ALG10B 0.69 10.8 0.51 1.55e-23 Morning vs. evening chronotype; LUSC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg06145435 chr7:1022769 CYP2W1 0.34 5.71 0.3 2.49e-8 Bronchopulmonary dysplasia; LUSC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg27144592 chr16:783916 NARFL 0.36 5.64 0.3 3.54e-8 Height; LUSC trans rs72674100 1.000 rs7689769 chr4:97968142 G/A cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs782590 0.902 rs7582278 chr2:55742924 C/G cg03859395 chr2:55845619 SMEK2 0.85 15.74 0.65 3.82e-42 Metabolic syndrome; LUSC cis rs7179456 0.544 rs2555357 chr15:59087115 A/G cg05156742 chr15:59063176 FAM63B 0.56 9.1 0.45 8.59e-18 Asperger disorder; LUSC cis rs79911532 0.515 rs79663210 chr7:75684326 G/A cg03592824 chr7:75666768 STYXL1 0.69 6.81 0.35 4.46e-11 Mononucleosis; LUSC cis rs16986825 0.664 rs5997409 chr22:29222096 T/C cg02153584 chr22:29168773 CCDC117 0.52 6.32 0.33 8.43e-10 Pancreatic cancer; LUSC cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.51 5.8 0.3 1.52e-8 Schizophrenia; LUSC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs12824058 0.707 rs2398509 chr12:130816464 T/C cg23887609 chr12:130822674 PIWIL1 0.45 6.35 0.33 6.92e-10 Menopause (age at onset); LUSC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg19346786 chr7:2764209 NA -0.42 -7.02 -0.36 1.26e-11 Height; LUSC trans rs1927790 0.643 rs1475296 chr13:97004273 T/C cg03198741 chr6:1003969 LOC285768 -0.41 -6.22 -0.32 1.5e-9 Body mass index; LUSC cis rs11711311 1.000 rs2305546 chr3:113503354 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.78 -0.3 1.75e-8 IgG glycosylation; LUSC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg19592336 chr6:28129416 ZNF389 0.46 6.38 0.33 5.9e-10 Parkinson's disease; LUSC cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg11766577 chr21:47581405 C21orf56 -0.41 -6.12 -0.32 2.67e-9 Testicular germ cell tumor; LUSC cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg03264133 chr6:25882463 NA -0.5 -9.11 -0.45 7.67e-18 Blood metabolite levels; LUSC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg06634786 chr22:41940651 POLR3H 0.49 5.7 0.3 2.6e-8 Vitiligo; LUSC cis rs17095355 0.539 rs3890722 chr10:111925233 T/C cg00817464 chr10:111662876 XPNPEP1 -0.55 -6.37 -0.33 6.14e-10 Biliary atresia; LUSC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg13114125 chr14:105738426 BRF1 -0.92 -15.77 -0.65 2.85e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs4595586 0.525 rs4768531 chr12:39417754 T/A cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.38 4.39e-13 Morning vs. evening chronotype; LUSC trans rs11098499 0.955 rs11931312 chr4:120159023 T/C cg25214090 chr10:38739885 LOC399744 0.46 6.7 0.34 8.74e-11 Corneal astigmatism; LUSC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg00334542 chr7:100209784 MOSPD3 -0.48 -5.94 -0.31 7.31e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs34734847 0.703 rs7978125 chr12:121167039 A/G cg21892295 chr12:121157589 UNC119B -0.35 -6.08 -0.32 3.37e-9 Mean corpuscular volume; LUSC cis rs7786808 0.615 rs1563066 chr7:158194935 A/C cg09998033 chr7:158218633 PTPRN2 -0.52 -8.34 -0.42 1.98e-15 Obesity-related traits; LUSC cis rs1538970 1.000 rs61791368 chr1:45867944 T/C cg05343316 chr1:45956843 TESK2 0.63 8.52 0.42 5.62e-16 Platelet count; LUSC cis rs73198271 0.603 rs546606 chr8:8595843 A/G cg01851573 chr8:8652454 MFHAS1 0.41 6.16 0.32 2.12e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.6 -0.43 3.15e-16 Body mass index; LUSC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg19748678 chr4:122722346 EXOSC9 0.74 11.19 0.52 6.82e-25 Type 2 diabetes; LUSC cis rs17253792 0.822 rs2147114 chr14:56077118 C/T cg01858014 chr14:56050164 KTN1 -0.86 -6.79 -0.35 5.08e-11 Putamen volume; LUSC cis rs6929568 1.000 rs9406109 chr6:8221425 C/T cg05398487 chr6:8064678 MUTED -0.39 -5.82 -0.3 1.35e-8 Coronary artery calcification; LUSC cis rs9837602 0.872 rs1489816 chr3:99769088 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 6.06 0.31 3.73e-9 Breast cancer; LUSC cis rs6596100 0.538 rs67504728 chr5:132194045 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.06 -0.31 3.73e-9 Breast cancer; LUSC cis rs870825 0.616 rs6852082 chr4:185645783 T/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs10489525 0.599 rs17033129 chr1:115611539 C/T cg01522456 chr1:115632236 TSPAN2 0.49 6.76 0.35 6.21e-11 Autism; LUSC cis rs870825 0.616 rs7678949 chr4:185635018 G/C cg04058563 chr4:185651563 MLF1IP 0.88 13.19 0.59 2.82e-32 Blood protein levels; LUSC trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -6.75 -0.35 6.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs13092825 1.000 rs74803054 chr3:113281370 A/T cg18753928 chr3:113234510 CCDC52 -0.38 -5.65 -0.3 3.5e-8 Dental caries; LUSC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.66 -0.39 2.01e-13 Alzheimer's disease (late onset); LUSC cis rs6696846 0.691 rs11240370 chr1:205118336 T/G cg03948781 chr1:205179583 DSTYK 0.32 6.17 0.32 1.94e-9 Red blood cell count; LUSC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg04369109 chr6:150039330 LATS1 -0.57 -8.4 -0.42 1.29e-15 Lung cancer; LUSC cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg12219531 chr12:120966889 COQ5 0.61 8.09 0.4 1.1e-14 High light scatter reticulocyte count; LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg08027265 chr7:2291960 NA -0.38 -6.26 -0.32 1.19e-9 Bipolar disorder and schizophrenia; LUSC cis rs7799006 0.634 rs34502289 chr7:2311266 G/A cg12823233 chr7:2316876 SNX8 -0.44 -7.35 -0.37 1.52e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9549260 0.664 rs1360719 chr13:41225874 G/C cg21288729 chr13:41239152 FOXO1 0.65 10.04 0.48 6.48e-21 Red blood cell count; LUSC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg11764359 chr7:65958608 NA -0.69 -10.69 -0.5 3.87e-23 Aortic root size; LUSC cis rs2279817 0.818 rs34036216 chr1:17986046 C/T cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.03 -0.31 4.32e-9 Neuroticism; LUSC cis rs6543140 0.964 rs918000 chr2:103067862 C/T cg09003973 chr2:102972529 NA 0.51 6.61 0.34 1.53e-10 Blood protein levels; LUSC cis rs9443645 0.527 rs12194642 chr6:79538791 G/A cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.03 -0.31 4.33e-9 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg09904177 chr6:26538194 HMGN4 0.68 12.21 0.56 1.35e-28 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs72634258 0.554 rs4562654 chr1:7934423 A/T cg26816564 chr1:7831052 VAMP3 0.72 9.39 0.46 9.85e-19 Inflammatory bowel disease; LUSC trans rs12200782 1.000 rs3800304 chr6:26598798 G/A cg11837749 chr1:55047332 ACOT11 0.57 6.0 0.31 5.01e-9 Small cell lung carcinoma; LUSC trans rs7618501 0.538 rs9856572 chr3:50109073 A/T cg21659725 chr3:3221576 CRBN -0.64 -10.44 -0.5 2.97e-22 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC trans rs2243480 1.000 rs7804223 chr7:65664559 T/G cg10756647 chr7:56101905 PSPH -0.87 -8.68 -0.43 1.74e-16 Diabetic kidney disease; LUSC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg24110177 chr3:50126178 RBM5 0.63 11.06 0.52 1.89e-24 Body mass index; LUSC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg18190219 chr22:46762943 CELSR1 -0.57 -6.29 -0.33 9.73e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11890956 chr21:40555474 PSMG1 -0.71 -11.1 -0.52 1.44e-24 Menarche (age at onset); LUSC cis rs62400317 0.859 rs6919813 chr6:45159177 C/T cg20913747 chr6:44695427 NA -0.48 -7.62 -0.38 2.67e-13 Total body bone mineral density; LUSC cis rs8114671 0.562 rs6088647 chr20:33505997 T/C cg07148914 chr20:33460835 GGT7 0.56 8.53 0.42 5.25e-16 Height; LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.46 -0.5 2.44e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg24690094 chr11:67383802 NA 0.41 8.16 0.41 6.97e-15 Mean corpuscular volume; LUSC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg18404041 chr3:52824283 ITIH1 -0.52 -9.82 -0.47 3.77e-20 Bipolar disorder; LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.44 -0.5 2.9e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg11279151 chr3:101281821 RG9MTD1 0.39 5.74 0.3 2.13e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs10276381 0.786 rs73300665 chr7:28227024 G/A cg23620719 chr7:28220237 JAZF1 0.64 6.92 0.35 2.34e-11 Crohn's disease; LUSC trans rs61931739 0.500 rs11053194 chr12:34440841 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.51e-34 Morning vs. evening chronotype; LUSC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg16339924 chr4:17578868 LAP3 0.55 8.43 0.42 1.04e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg01802117 chr1:53393560 SCP2 0.38 6.3 0.33 9.42e-10 Monocyte count; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg16647868 chr5:131706066 SLC22A5 0.34 5.7 0.3 2.64e-8 Blood metabolite levels; LUSC cis rs9921222 0.500 rs11648673 chr16:377794 G/A cg02086790 chr16:375327 AXIN1 -0.4 -6.18 -0.32 1.83e-9 Bone mineral density (spine);Bone mineral density; LUSC trans rs12310956 0.532 rs1352211 chr12:33983132 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.83 0.51 1.22e-23 Morning vs. evening chronotype; LUSC cis rs9527 0.615 rs3897401 chr10:104696379 T/C cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.46 1.42e-18 Arsenic metabolism; LUSC cis rs11098499 0.863 rs13149407 chr4:120437825 A/G cg24375607 chr4:120327624 NA 0.76 11.09 0.52 1.51e-24 Corneal astigmatism; LUSC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg26441486 chr22:50317300 CRELD2 0.54 8.21 0.41 4.9e-15 Schizophrenia; LUSC cis rs6541297 1.000 rs4846909 chr1:230285372 G/A cg05784532 chr1:230284198 GALNT2 0.5 7.59 0.38 3.26e-13 Coronary artery disease; LUSC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg09835421 chr16:68378352 PRMT7 -0.55 -6.17 -0.32 2e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.49 -8.26 -0.41 3.38e-15 Lymphocyte counts; LUSC cis rs9549260 0.753 rs9549238 chr13:41179321 G/A cg21288729 chr13:41239152 FOXO1 0.53 5.96 0.31 6.31e-9 Red blood cell count; LUSC cis rs9472414 0.510 rs227840 chr6:44686304 C/G cg20913747 chr6:44695427 NA -0.4 -5.85 -0.3 1.16e-8 Height; LUSC cis rs7927592 0.913 rs7102898 chr11:68328870 G/A cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.54e-9 Total body bone mineral density; LUSC cis rs911119 0.955 rs6048945 chr20:23602228 C/T cg16589663 chr20:23618590 CST3 0.59 7.08 0.36 8.56e-12 Chronic kidney disease; LUSC trans rs2018683 0.584 rs4722880 chr7:28999197 C/T cg19402173 chr7:128379420 CALU -0.51 -7.55 -0.38 4.11e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.16 0.36 5.05e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs3862435 0.764 rs6496681 chr15:91051011 C/T cg22089800 chr15:90895588 ZNF774 -0.56 -6.02 -0.31 4.67e-9 Response to exercise (triglyceride level interaction); LUSC cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg05347473 chr6:146136440 FBXO30 0.58 10.14 0.49 3.06e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs11971779 0.590 rs6944104 chr7:139051120 T/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7202877 0.561 rs9933956 chr16:75362813 T/C cg04384234 chr16:75411784 CFDP1 -0.65 -9.25 -0.45 2.69e-18 Type 2 diabetes;Type 1 diabetes; LUSC cis rs4718428 1.000 rs4718421 chr7:66350300 C/T cg18252515 chr7:66147081 NA -0.39 -5.78 -0.3 1.72e-8 Corneal structure; LUSC cis rs9814567 0.896 rs7653807 chr3:134345724 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.97 -0.61 2.98e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11098499 0.863 rs11736416 chr4:120431661 C/T cg09307838 chr4:120376055 NA 0.75 10.98 0.51 3.78e-24 Corneal astigmatism; LUSC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg06027949 chr8:82754900 SNX16 0.43 5.81 0.3 1.43e-8 Diastolic blood pressure; LUSC cis rs4474465 1.000 rs11237499 chr11:78163164 A/T cg27205649 chr11:78285834 NARS2 -0.51 -5.99 -0.31 5.49e-9 Alzheimer's disease (survival time); LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.08e-10 Aortic root size; LUSC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg13939156 chr17:80058883 NA -0.32 -6.36 -0.33 6.6e-10 Life satisfaction; LUSC cis rs708547 0.830 rs1713983 chr4:57883084 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.72 9.71 0.47 8.5e-20 Response to bleomycin (chromatid breaks); LUSC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg26752003 chr8:145688521 CYHR1 0.45 7.32 0.37 1.9e-12 Age at first birth; LUSC cis rs754466 0.606 rs12356375 chr10:79594514 C/A cg17075019 chr10:79541650 NA -0.78 -12.52 -0.57 9.61e-30 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg08807101 chr21:30365312 RNF160 -0.67 -11.42 -0.53 1e-25 Dental caries; LUSC trans rs4553720 0.896 rs4383250 chr18:62177797 A/T cg17502984 chr6:80714315 TTK 0.47 6.37 0.33 6.42e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); LUSC cis rs17021463 0.902 rs62320439 chr4:95248721 G/C cg11021082 chr4:95130006 SMARCAD1 0.42 7.6 0.38 3.04e-13 Testicular germ cell tumor; LUSC cis rs1568889 1.000 rs12797155 chr11:28290866 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.32 0.45 1.66e-18 Bipolar disorder; LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2797160 1.000 rs1777195 chr6:126006861 A/C cg05901451 chr6:126070800 HEY2 0.57 8.56 0.42 4.05e-16 Endometrial cancer; LUSC trans rs10016947 0.826 rs7679745 chr4:104266305 C/T cg02356640 chr11:1501973 HCCA2 0.69 5.98 0.31 5.79e-9 Breast cancer; LUSC cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg09184832 chr6:79620586 NA -0.44 -7.2 -0.37 3.94e-12 Intelligence (multi-trait analysis); LUSC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg03732007 chr1:2071316 PRKCZ 0.55 9.83 0.47 3.38e-20 Height; LUSC cis rs11585357 0.895 rs34324150 chr1:17632464 C/G cg08277548 chr1:17600880 PADI3 -0.59 -6.19 -0.32 1.72e-9 Hair shape; LUSC cis rs9814567 1.000 rs9289476 chr3:134237103 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.28 -0.59 1.35e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1712517 0.740 rs11191663 chr10:105118462 C/T cg05636881 chr10:105038444 INA 0.41 6.75 0.35 6.73e-11 Migraine; LUSC cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC cis rs7312933 0.585 rs7969814 chr12:42669657 C/G cg17420585 chr12:42539391 GXYLT1 -0.33 -6.39 -0.33 5.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7577696 0.785 rs2294179 chr2:32354005 G/A cg02381751 chr2:32503542 YIPF4 -0.44 -6.22 -0.32 1.46e-9 Inflammatory biomarkers; LUSC cis rs3820928 0.839 rs13398103 chr2:227859693 T/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.52 -0.38 5.01e-13 Pulmonary function; LUSC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg13683864 chr3:40499215 RPL14 -1.13 -21.68 -0.76 1.11e-65 Renal cell carcinoma; LUSC trans rs11098499 0.569 rs10023641 chr4:120258410 C/G cg25214090 chr10:38739885 LOC399744 0.41 6.34 0.33 7.47e-10 Corneal astigmatism; LUSC cis rs12478296 0.534 rs67092377 chr2:243002171 T/G cg06360820 chr2:242988706 NA -0.65 -8.17 -0.41 6.6e-15 Obesity-related traits; LUSC cis rs6430585 0.528 rs3098102 chr2:136654833 C/T cg07169764 chr2:136633963 MCM6 1.01 15.27 0.64 2.72e-40 Corneal structure; LUSC cis rs6489882 0.867 rs6489869 chr12:113363922 A/C cg20102336 chr12:113376681 OAS3 -0.41 -5.89 -0.31 9.59e-9 Chronic lymphocytic leukemia; LUSC cis rs2386661 0.547 rs57893347 chr10:5646191 G/A cg17085576 chr10:5658249 NA -0.43 -6.42 -0.33 4.72e-10 Breast cancer; LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg15790184 chr11:494944 RNH1 0.5 5.75 0.3 2.01e-8 Body mass index; LUSC cis rs4785763 0.570 rs4785759 chr16:90050880 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.57 -9.09 -0.45 9.19e-18 Melanoma; LUSC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg18827107 chr12:86230957 RASSF9 -0.5 -7.41 -0.38 1.05e-12 Major depressive disorder; LUSC cis rs6754311 0.512 rs12998387 chr2:136507039 A/G cg07169764 chr2:136633963 MCM6 -0.6 -7.93 -0.4 3.27e-14 Mosquito bite size; LUSC cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -7.95 -0.4 2.87e-14 Axial length; LUSC cis rs7914558 0.505 rs12260436 chr10:104741114 A/C cg23093090 chr10:104574429 C10orf26 -0.37 -5.86 -0.31 1.1e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.21 0.37 3.85e-12 Platelet count; LUSC cis rs28595532 1.000 rs41455648 chr4:119718030 A/G cg11846333 chr4:119757529 SEC24D 0.87 6.18 0.32 1.88e-9 Cannabis dependence symptom count; LUSC cis rs7789940 0.809 rs12533836 chr7:75935622 G/T cg15798862 chr7:76129360 DTX2 -0.49 -7.99 -0.4 2.14e-14 Multiple sclerosis; LUSC cis rs4969178 0.600 rs4969184 chr17:76393413 G/A cg20026190 chr17:76395443 PGS1 0.33 5.79 0.3 1.63e-8 HDL cholesterol levels; LUSC cis rs7216064 0.954 rs8079291 chr17:65887622 A/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs11758351 0.929 rs75475698 chr6:26190609 C/G cg01420254 chr6:26195488 NA 0.7 7.46 0.38 7.56e-13 Gout;Renal underexcretion gout; LUSC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg11645453 chr3:52864694 ITIH4 0.33 7.61 0.38 2.76e-13 Bipolar disorder; LUSC cis rs3806843 0.966 rs3806842 chr5:140212676 C/T cg19875535 chr5:140030758 IK 0.47 7.62 0.38 2.66e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs12597458 0.789 rs7186207 chr16:72035359 C/T cg01557791 chr16:72042693 DHODH -0.6 -9.7 -0.47 9.44e-20 Prostate cancer; LUSC cis rs10779751 0.770 rs11121691 chr1:11181327 C/T cg08854313 chr1:11322531 MTOR -0.82 -12.73 -0.57 1.56e-30 Body mass index; LUSC cis rs748404 0.650 rs518234 chr15:43573421 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.57 8.84 0.44 5.69e-17 Lung cancer; LUSC cis rs10504073 0.584 rs62507182 chr8:49942500 C/A cg00325661 chr8:49890786 NA 0.7 11.24 0.52 4.43e-25 Blood metabolite ratios; LUSC cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg12573674 chr2:1569213 NA -0.64 -8.84 -0.44 5.53e-17 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs73206853 0.841 rs16940885 chr12:110971666 A/G cg12870014 chr12:110450643 ANKRD13A -0.59 -6.38 -0.33 5.85e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9309473 0.687 rs11126399 chr2:73613341 G/A cg20560298 chr2:73613845 ALMS1 -0.59 -8.96 -0.44 2.37e-17 Metabolite levels; LUSC cis rs9926296 0.744 rs460984 chr16:89713174 C/T cg26513180 chr16:89883248 FANCA -0.55 -8.09 -0.4 1.1e-14 Vitiligo; LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg09877947 chr5:131593287 PDLIM4 -0.58 -9.66 -0.47 1.21e-19 Acylcarnitine levels; LUSC cis rs2486288 0.587 rs12899942 chr15:45547280 T/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.01 -0.4 1.89e-14 Glomerular filtration rate; LUSC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11890956 chr21:40555474 PSMG1 1.01 18.96 0.72 6.39e-55 Cognitive function; LUSC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg00647820 chr17:40259828 DHX58 0.49 6.74 0.35 7.06e-11 Fibrinogen levels; LUSC cis rs72781680 0.898 rs12622290 chr2:23979894 C/G cg20701182 chr2:24300061 SF3B14 0.57 6.02 0.31 4.55e-9 Lymphocyte counts; LUSC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg00484396 chr16:3507460 NAT15 -0.45 -7.51 -0.38 5.39e-13 Body mass index (adult); LUSC cis rs68149176 0.772 rs61527026 chr16:87878783 C/G cg03553613 chr16:87879502 SLC7A5 -0.45 -5.78 -0.3 1.69e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4803468 1.000 rs284658 chr19:41929988 G/A cg09537434 chr19:41945824 ATP5SL -0.94 -16.22 -0.66 5.01e-44 Height; LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg05368731 chr17:41323189 NBR1 0.92 15.74 0.65 3.76e-42 Menopause (age at onset); LUSC cis rs806215 1.000 rs712700 chr7:127250907 T/C cg25922125 chr7:127225783 GCC1 0.57 7.17 0.37 4.96e-12 Type 2 diabetes; LUSC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg05973401 chr12:123451056 ABCB9 0.55 6.81 0.35 4.68e-11 Neutrophil percentage of white cells; LUSC cis rs7945705 0.875 rs10769957 chr11:8809016 A/C cg12365402 chr11:9010492 NRIP3 -0.42 -7.54 -0.38 4.54e-13 Hemoglobin concentration; LUSC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -6.7 -0.34 9.02e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3733585 0.631 rs3822236 chr4:10119961 T/G cg11266682 chr4:10021025 SLC2A9 -0.5 -8.58 -0.42 3.63e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg03461704 chr1:205818484 PM20D1 0.39 6.69 0.34 9.32e-11 Menarche (age at onset); LUSC cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.44 -6.49 -0.33 3.07e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs977987 0.778 rs12445726 chr16:75465575 C/T cg03315344 chr16:75512273 CHST6 0.5 9.52 0.46 3.5e-19 Dupuytren's disease; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs9902453 0.904 rs7225686 chr17:28356744 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.74 -0.51 2.52e-23 Coffee consumption (cups per day); LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg15790184 chr11:494944 RNH1 0.42 6.4 0.33 5.37e-10 Systemic lupus erythematosus; LUSC cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg00071950 chr4:10020882 SLC2A9 0.46 7.63 0.39 2.53e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7681440 0.538 rs2737015 chr4:90745283 T/C cg06632027 chr4:90757378 SNCA -0.36 -5.74 -0.3 2.17e-8 Dementia with Lewy bodies; LUSC cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -11.26 -0.52 3.88e-25 Systemic lupus erythematosus; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg27535305 chr1:53392650 SCP2 -0.46 -9.07 -0.44 1.05e-17 Monocyte count; LUSC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs4746822 0.954 rs5030938 chr10:70975916 A/G cg14418922 chr10:70824840 NA 0.38 6.29 0.33 1.02e-9 Glycemic traits (pregnancy); LUSC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 6.11 0.32 2.7e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs1670533 0.932 rs6599276 chr4:1056827 T/C cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs12541635 0.934 rs62527400 chr8:107054229 G/A cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.69e-20 Age of smoking initiation; LUSC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg23158103 chr7:148848205 ZNF398 -0.45 -6.87 -0.35 3.25e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg25019033 chr10:957182 NA 0.48 5.89 0.31 9.33e-9 Eosinophil percentage of granulocytes; LUSC cis rs7043114 0.563 rs10820988 chr9:95317008 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.35 -6.27 -0.32 1.11e-9 Height; LUSC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.25 0.52 4.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg00071950 chr4:10020882 SLC2A9 0.53 8.85 0.44 5.07e-17 Bone mineral density; LUSC cis rs7635838 0.654 rs347585 chr3:11286220 C/T cg00170343 chr3:11313890 ATG7 0.5 7.54 0.38 4.38e-13 HDL cholesterol; LUSC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.65 13.71 0.6 3.03e-34 Monocyte percentage of white cells; LUSC trans rs629535 0.814 rs614050 chr8:70065642 G/A cg21567404 chr3:27674614 NA 0.97 15.48 0.65 3.82e-41 Dupuytren's disease; LUSC cis rs6964587 1.000 rs11772102 chr7:91558326 A/T cg01689657 chr7:91764605 CYP51A1 -0.32 -5.86 -0.31 1.14e-8 Breast cancer; LUSC cis rs10170846 0.789 rs972650 chr2:223520287 C/T cg25565276 chr2:223520875 FARSB 0.64 9.7 0.47 9.46e-20 Schizophrenia (inflammation and infection response interaction); LUSC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg05585544 chr11:47624801 NA -0.41 -7.24 -0.37 3.11e-12 Subjective well-being; LUSC cis rs17685 0.753 rs1639617 chr7:75701728 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.84 -0.39 6.14e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7582720 1.000 rs7560547 chr2:203757916 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg23158103 chr7:148848205 ZNF398 -0.45 -7.11 -0.36 7.26e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9612 1.000 rs346523 chr19:44260681 A/C cg08581076 chr19:44259116 C19orf61 0.53 6.71 0.34 8.22e-11 Exhaled nitric oxide output; LUSC cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg03146154 chr1:46216737 IPP 0.52 7.55 0.38 4.2e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9354308 0.933 rs12203567 chr6:66589062 T/C cg07460842 chr6:66804631 NA 0.47 5.81 0.3 1.47e-8 Metabolite levels; LUSC cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -8.81 -0.43 7.03e-17 Chronic sinus infection; LUSC cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg26408565 chr15:76604113 ETFA -0.52 -8.39 -0.42 1.4e-15 Blood metabolite levels; LUSC cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg11584989 chr19:19387371 SF4 -0.62 -7.26 -0.37 2.72e-12 Bipolar disorder; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg16405210 chr4:1374714 KIAA1530 -0.54 -8.38 -0.42 1.45e-15 Obesity-related traits; LUSC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg04111992 chr7:158790115 NA -0.44 -7.0 -0.36 1.38e-11 Facial morphology (factor 20); LUSC cis rs1670533 1.000 rs7673898 chr4:1056569 C/A cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC cis rs2625529 0.824 rs12595464 chr15:72294398 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.44 -0.38 8.7e-13 Red blood cell count; LUSC trans rs2898290 0.622 rs1478890 chr8:11355602 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -8.0 -0.4 2.03e-14 Systolic blood pressure; LUSC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg12311346 chr5:56204834 C5orf35 -0.61 -9.35 -0.46 1.32e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs2742417 0.935 rs2742393 chr3:45757417 T/A cg09608765 chr3:45636137 LIMD1 -0.37 -7.42 -0.38 9.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg14552801 chr7:65878734 NA -0.43 -5.97 -0.31 6.01e-9 Aortic root size; LUSC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.6 0.5 8.15e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6977660 1.000 rs10260360 chr7:19792824 T/C cg05791153 chr7:19748676 TWISTNB 0.63 7.02 0.36 1.24e-11 Thyroid stimulating hormone; LUSC cis rs7177699 0.557 rs4073322 chr15:79122541 G/C cg00540400 chr15:79124168 NA 0.45 7.83 0.39 6.34e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6740322 0.748 rs6544636 chr2:43487486 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -6.47 -0.33 3.44e-10 Coronary artery disease; LUSC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg03036452 chr22:46663545 TTC38 0.65 5.89 0.31 9.28e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg26528668 chr16:1614120 IFT140 0.46 7.64 0.39 2.35e-13 Coronary artery disease; LUSC trans rs61931739 0.534 rs10844725 chr12:34009504 C/A cg13010199 chr12:38710504 ALG10B 0.55 8.27 0.41 3.16e-15 Morning vs. evening chronotype; LUSC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11644478 chr21:40555479 PSMG1 0.94 18.8 0.72 2.63e-54 Cognitive function; LUSC cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg06064525 chr11:970664 AP2A2 -0.49 -10.74 -0.51 2.52e-23 Alzheimer's disease (late onset); LUSC cis rs6977660 0.660 rs13225400 chr7:19817016 A/G cg05791153 chr7:19748676 TWISTNB 0.67 7.1 0.36 7.78e-12 Thyroid stimulating hormone; LUSC cis rs1163251 0.623 rs493427 chr1:120207482 A/T cg19096424 chr1:120255104 PHGDH -0.43 -6.0 -0.31 5.21e-9 Blood metabolite levels; LUSC cis rs2980439 0.556 rs2921059 chr8:8317887 G/T cg06636001 chr8:8085503 FLJ10661 0.67 10.87 0.51 9.25e-24 Neuroticism; LUSC cis rs68170813 0.641 rs79434636 chr7:107105656 A/C cg02696742 chr7:106810147 HBP1 -0.65 -9.6 -0.46 1.99e-19 Coronary artery disease; LUSC cis rs7264396 0.563 rs6060560 chr20:34278890 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -8.53 -0.42 5.09e-16 Total cholesterol levels; LUSC cis rs2219968 0.756 rs10283381 chr8:78922806 G/A cg00738934 chr8:78996279 NA -0.42 -7.55 -0.38 4.26e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs2439831 1.000 rs2245908 chr15:43731454 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.97 10.95 0.51 4.92e-24 Lung cancer in ever smokers; LUSC cis rs11039100 0.607 rs11038962 chr11:5781339 C/T cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7584330 0.554 rs10183995 chr2:238433307 G/A cg16989719 chr2:238392110 NA -0.39 -5.69 -0.3 2.79e-8 Prostate cancer; LUSC cis rs7727544 0.606 rs17622208 chr5:131717050 G/A cg14196790 chr5:131705035 SLC22A5 0.52 8.63 0.43 2.57e-16 Blood metabolite levels; LUSC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg24642439 chr20:33292090 TP53INP2 0.54 8.27 0.41 3.22e-15 Height; LUSC cis rs10979 1.000 rs9386037 chr6:143891950 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.93 -0.55 1.41e-27 Hypospadias; LUSC cis rs7575217 0.697 rs796067 chr2:101707009 C/T cg23907051 chr2:101730305 TBC1D8 -0.29 -7.68 -0.39 1.81e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs11098499 1.000 rs12506395 chr4:120185094 C/T cg09307838 chr4:120376055 NA 0.68 9.61 0.47 1.83e-19 Corneal astigmatism; LUSC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg18196295 chr10:418757 DIP2C -0.47 -7.76 -0.39 1.04e-13 Psychosis in Alzheimer's disease; LUSC cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg05535760 chr7:792225 HEATR2 0.79 9.53 0.46 3.23e-19 Cerebrospinal P-tau181p levels; LUSC cis rs4343996 0.967 rs4722674 chr7:3357188 C/G cg21248987 chr7:3385318 SDK1 -0.39 -6.58 -0.34 1.83e-10 Motion sickness; LUSC cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.46 -0.46 5.76e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg21643547 chr1:205240462 TMCC2 -0.53 -10.18 -0.49 2.21e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg08270630 chr22:50330655 NA 0.44 6.67 0.34 1.05e-10 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09920549 chr4:2264324 MXD4 -0.4 -6.02 -0.31 4.65e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.8 0.47 4.22e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.55 -8.73 -0.43 1.28e-16 Personality dimensions; LUSC trans rs4332037 0.950 rs11767515 chr7:1941051 C/T cg25206134 chr2:45395956 NA 0.57 6.52 0.34 2.6200000000000003e-10 Bipolar disorder; LUSC cis rs9420 0.961 rs7949841 chr11:57524700 G/C cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.22e-10 Schizophrenia; LUSC cis rs473651 0.901 rs563282 chr2:239329736 T/C cg18131467 chr2:239335373 ASB1 0.93 17.94 0.7 6.81e-51 Multiple system atrophy; LUSC cis rs2742234 0.590 rs2435338 chr10:43642115 A/G cg15436174 chr10:43711423 RASGEF1A -0.44 -7.36 -0.37 1.49e-12 Hirschsprung disease; LUSC cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4664308 0.905 rs7567781 chr2:160999537 A/G cg03641300 chr2:160917029 PLA2R1 -0.67 -11.58 -0.54 2.79e-26 Idiopathic membranous nephropathy; LUSC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.79e-9 Vitiligo; LUSC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg18252515 chr7:66147081 NA -1.23 -14.22 -0.61 3.4e-36 Gout; LUSC cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg12826209 chr6:26865740 GUSBL1 0.76 6.5 0.33 2.98e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs6582630 0.585 rs12422588 chr12:38478675 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.24 -0.41 3.86e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg12219531 chr12:120966889 COQ5 0.57 7.72 0.39 1.36e-13 High light scatter reticulocyte count; LUSC cis rs9926296 0.624 rs1110331 chr16:89774396 A/G cg04287289 chr16:89883240 FANCA -0.39 -6.02 -0.31 4.52e-9 Vitiligo; LUSC cis rs7647973 0.710 rs1532204 chr3:49609477 C/G cg03060546 chr3:49711283 APEH 0.64 6.96 0.36 1.76e-11 Menarche (age at onset); LUSC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg18479299 chr3:125709523 NA -0.51 -5.83 -0.3 1.33e-8 Blood pressure (smoking interaction); LUSC cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg10523860 chr14:103875565 MARK3 -0.38 -6.15 -0.32 2.24e-9 Body mass index; LUSC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg03709012 chr19:19516395 GATAD2A 0.88 15.06 0.64 1.84e-39 Tonsillectomy; LUSC cis rs10504229 0.500 rs9772760 chr8:57986999 G/C cg21724239 chr8:58056113 NA 0.42 5.64 0.3 3.55e-8 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.863 rs7695620 chr4:120452776 G/A cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg23649088 chr2:200775458 C2orf69 0.58 7.15 0.36 5.63e-12 Schizophrenia; LUSC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg08499158 chr17:42289980 UBTF 0.49 8.36 0.42 1.68e-15 Total body bone mineral density; LUSC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg23887609 chr12:130822674 PIWIL1 0.48 7.05 0.36 1.04e-11 Menopause (age at onset); LUSC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg12310025 chr6:25882481 NA -0.39 -6.35 -0.33 7.08e-10 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg15445000 chr17:37608096 MED1 0.4 6.75 0.35 6.65e-11 Glomerular filtration rate (creatinine); LUSC cis rs72781680 0.716 rs2712056 chr2:23959131 C/T cg08917208 chr2:24149416 ATAD2B 0.61 6.8 0.35 4.74e-11 Lymphocyte counts; LUSC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2692947 0.800 rs4332959 chr2:96549121 C/T cg22654517 chr2:96458247 NA 0.37 7.19 0.37 4.37e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg01416388 chr22:39784598 NA -0.43 -6.66 -0.34 1.12e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs10266483 0.774 rs56055804 chr7:63870801 G/T cg24201672 chr7:64023550 ZNF680 0.5 6.1 0.32 2.88e-9 Response to statin therapy; LUSC cis rs9814567 1.000 rs6787371 chr3:134254991 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.43 -0.59 3.39e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs12677056 0.739 rs4876463 chr8:113315064 C/A cg12159992 chr12:102059490 MYBPC1 0.36 6.01 0.31 4.84e-9 Peripheral artery disease; LUSC cis rs6977940 0.598 rs73033411 chr7:2881550 G/C cg19731401 chr7:2775893 GNA12 0.73 9.53 0.46 3.37e-19 White matter integrity; LUSC cis rs12971120 0.891 rs3794953 chr18:72180519 C/T cg25817165 chr18:72167213 CNDP2 -0.72 -8.39 -0.42 1.36e-15 Refractive error; LUSC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg11366901 chr6:160182831 ACAT2 0.92 13.16 0.58 3.76e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs7582180 0.764 rs12999779 chr2:100924321 T/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.46 -0.42 8.2e-16 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg17385448 chr1:15911702 AGMAT 0.37 6.23 0.32 1.41e-9 Systolic blood pressure; LUSC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg21545522 chr1:205238299 TMCC2 0.5 9.36 0.46 1.19e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg24060327 chr5:131705240 SLC22A5 0.53 8.78 0.43 8.63e-17 Acylcarnitine levels; LUSC cis rs10875746 0.855 rs12296244 chr12:48441479 C/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.7 -0.3 2.69e-8 Longevity (90 years and older); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08578305 chr12:25403937 KRAS -0.4 -6.03 -0.31 4.26e-9 Electrocardiographic conduction measures; LUSC cis rs13082711 0.911 rs77037289 chr3:27512971 C/T cg02860705 chr3:27208620 NA 0.49 8.2 0.41 5.1e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg11266682 chr4:10021025 SLC2A9 0.55 10.04 0.48 6.69e-21 Bone mineral density; LUSC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg09035930 chr12:129282057 SLC15A4 0.65 13.29 0.59 1.2e-32 Systemic lupus erythematosus; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 11.1 0.52 1.44e-24 Alzheimer's disease; LUSC cis rs225245 0.782 rs321599 chr17:33905745 C/T cg05299278 chr17:33885742 SLFN14 0.31 6.9 0.35 2.68e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs4285028 0.699 rs7637495 chr3:121573850 C/T cg11130432 chr3:121712080 ILDR1 -0.65 -9.83 -0.47 3.45e-20 Multiple sclerosis; LUSC cis rs1790761 0.692 rs10444362 chr11:67333090 G/A cg08355456 chr11:67383691 NA 0.37 6.83 0.35 3.96e-11 Mean corpuscular volume; LUSC cis rs28595532 0.800 rs114321375 chr4:119341663 G/A cg02775129 chr4:119771670 NA -0.76 -6.33 -0.33 7.84e-10 Cannabis dependence symptom count; LUSC cis rs12410462 0.681 rs4131980 chr1:227572123 A/G cg10327440 chr1:227177885 CDC42BPA -0.62 -5.79 -0.3 1.59e-8 Major depressive disorder; LUSC cis rs4780401 0.632 rs8055462 chr16:11834821 T/C cg01061890 chr16:11836724 TXNDC11 -0.56 -8.36 -0.42 1.69e-15 Rheumatoid arthritis; LUSC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg11764359 chr7:65958608 NA 0.79 12.74 0.57 1.48e-30 Aortic root size; LUSC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg11608241 chr8:8085544 FLJ10661 0.41 5.75 0.3 2.06e-8 Mood instability; LUSC trans rs7647973 0.593 rs28535523 chr3:49848414 C/T cg21659725 chr3:3221576 CRBN 0.71 8.51 0.42 5.77e-16 Menarche (age at onset); LUSC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.64 -8.27 -0.41 3.23e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs599083 0.793 rs471966 chr11:68173861 C/T cg01657329 chr11:68192670 LRP5 0.51 7.71 0.39 1.44e-13 Bone mineral density (spine); LUSC cis rs77106637 0.769 rs11603313 chr11:72588177 G/A cg03713592 chr11:72463424 ARAP1 0.75 8.86 0.44 4.75e-17 Type 2 diabetes; LUSC trans rs79976124 0.797 rs79522358 chr6:66641140 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.81 0.43 7.1e-17 Type 2 diabetes; LUSC cis rs72717009 0.825 rs7539468 chr1:161477066 G/A cg23840854 chr1:161414152 NA -0.92 -11.2 -0.52 6.13e-25 Rheumatoid arthritis; LUSC cis rs614226 0.935 rs7956998 chr12:120994932 G/A cg21053147 chr12:120880522 NA -0.48 -5.93 -0.31 7.76e-9 Type 1 diabetes nephropathy; LUSC cis rs9815354 1.000 rs1716661 chr3:41962818 C/T cg03022575 chr3:42003672 ULK4 -0.51 -5.82 -0.3 1.41e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs600231 0.665 rs1784858 chr11:65222952 T/C cg17120908 chr11:65337727 SSSCA1 -0.53 -9.36 -0.46 1.21e-18 Bone mineral density; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -6.02 -0.31 4.66e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg18247339 chr14:35183597 CFL2 0.48 6.19 0.32 1.72e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs981844 0.725 rs872453 chr4:154727131 T/C cg14289246 chr4:154710475 SFRP2 0.44 5.82 0.3 1.38e-8 Response to statins (LDL cholesterol change); LUSC cis rs9463078 0.547 rs34907292 chr6:44729708 A/G cg25276700 chr6:44698697 NA 0.3 6.3 0.33 9.28e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9325144 0.723 rs1586373 chr12:39181582 G/A cg26384229 chr12:38710491 ALG10B -0.61 -9.3 -0.45 1.95e-18 Morning vs. evening chronotype; LUSC cis rs7106204 0.541 rs75552854 chr11:24231824 G/A ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Response to Homoharringtonine (cytotoxicity); LUSC cis rs432925 0.600 rs214249 chr16:348687 T/G cg08823186 chr16:347294 AXIN1 0.35 6.15 0.32 2.21e-9 Morning vs. evening chronotype; LUSC cis rs11924390 0.749 rs822364 chr3:186452716 A/G cg12454167 chr3:186435060 KNG1 0.29 7.56 0.38 3.97e-13 Adiponectin levels; LUSC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg08999081 chr20:33150536 PIGU 0.44 8.14 0.41 7.93e-15 Coronary artery disease; LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg16325326 chr1:53192061 ZYG11B -0.91 -16.87 -0.68 1.29e-46 Monocyte count; LUSC cis rs3849570 0.922 rs3772895 chr3:81769493 A/G cg07356753 chr3:81810745 GBE1 -0.7 -11.43 -0.53 9.49e-26 Waist circumference;Body mass index; LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg23758822 chr17:41437982 NA 1.04 19.81 0.74 2.6e-58 Menopause (age at onset); LUSC cis rs1153858 1.000 rs1153849 chr15:45695695 G/A cg26924012 chr15:45694286 SPATA5L1 1.1 19.12 0.72 1.38e-55 Homoarginine levels; LUSC cis rs7945718 0.967 rs7930077 chr11:12778769 C/T cg25843174 chr11:12811716 TEAD1 0.31 6.99 0.36 1.48e-11 Educational attainment (years of education); LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg01585723 chr16:33734837 NA 0.46 7.82 0.39 6.81e-14 Menopause (age at onset); LUSC cis rs3815700 0.920 rs10426856 chr19:33096406 A/G cg02997394 chr19:33096574 ANKRD27 0.83 9.61 0.47 1.89e-19 Eosinophilic esophagitis; LUSC cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC cis rs3008870 0.583 rs3008861 chr1:67396222 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.93 13.14 0.58 4.42e-32 Lymphocyte percentage of white cells; LUSC cis rs9527 0.544 rs1572578 chr10:104822431 C/G cg04362960 chr10:104952993 NT5C2 0.62 9.62 0.47 1.71e-19 Arsenic metabolism; LUSC cis rs4654899 0.655 rs4654883 chr1:21213708 C/T cg01072550 chr1:21505969 NA 0.5 7.63 0.39 2.41e-13 Superior frontal gyrus grey matter volume; LUSC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg26314531 chr2:26401878 FAM59B -0.68 -9.19 -0.45 4.28e-18 Gut microbiome composition (summer); LUSC trans rs3733585 0.805 rs882222 chr4:9981294 G/A cg26043149 chr18:55253948 FECH 0.47 7.16 0.36 5.05e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg00745463 chr17:30367425 LRRC37B 0.78 8.68 0.43 1.8e-16 Hip circumference adjusted for BMI; LUSC cis rs13082711 0.871 rs35572617 chr3:27499247 A/T cg02860705 chr3:27208620 NA 0.51 8.66 0.43 2.03e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs11166629 1.000 rs6981735 chr8:135635730 T/C cg21672855 chr8:135614777 ZFAT 0.37 5.93 0.31 7.49e-9 Smoking quantity; LUSC cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg12564285 chr5:131593104 PDLIM4 -0.38 -6.32 -0.33 8.55e-10 Blood metabolite levels; LUSC cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.35 0.56 4.17e-29 Motion sickness; LUSC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg20203395 chr5:56204925 C5orf35 -0.7 -9.78 -0.47 4.82e-20 Initial pursuit acceleration; LUSC cis rs6545883 0.811 rs2921718 chr2:61795267 C/A cg15711740 chr2:61764176 XPO1 -0.47 -7.53 -0.38 4.93e-13 Tuberculosis; LUSC cis rs6815814 0.861 rs28690449 chr4:38789132 C/T cg06935464 chr4:38784597 TLR10 0.46 5.85 0.3 1.15e-8 Breast cancer; LUSC cis rs4964805 0.865 rs35371470 chr12:104203720 C/G cg02344784 chr12:104178138 NT5DC3 0.41 6.45 0.33 3.93e-10 Attention deficit hyperactivity disorder; LUSC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg24829409 chr8:58192753 C8orf71 -0.61 -6.57 -0.34 1.94e-10 Developmental language disorder (linguistic errors); LUSC cis rs977987 0.836 rs8055974 chr16:75470986 C/G cg04384234 chr16:75411784 CFDP1 -0.42 -7.0 -0.36 1.38e-11 Dupuytren's disease; LUSC cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg02389323 chr16:88786976 FAM38A 0.87 9.42 0.46 7.52e-19 Plateletcrit; LUSC cis rs9463078 0.547 rs764397 chr6:44710771 C/A cg25276700 chr6:44698697 NA 0.3 6.2 0.32 1.66e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24291776 chr10:1034677 GTPBP4 -0.48 -6.38 -0.33 6.04e-10 Hepatitis; LUSC cis rs870825 0.616 rs7667449 chr4:185641711 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.27 0.59 1.47e-32 Blood protein levels; LUSC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.61 0.34 1.55e-10 Lung cancer; LUSC cis rs5753037 0.813 rs9614100 chr22:30288339 A/T cg11564601 chr22:30592435 NA 0.33 5.84 0.3 1.21e-8 Type 1 diabetes; LUSC cis rs9341835 0.740 rs7763834 chr6:64149357 T/C cg03326410 chr6:64151739 NA -0.37 -6.13 -0.32 2.53e-9 Schizophrenia; LUSC cis rs12530845 0.943 rs55889179 chr7:135331631 C/T cg23117316 chr7:135346802 PL-5283 -0.58 -9.63 -0.47 1.55e-19 Red blood cell traits; LUSC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg02187348 chr16:89574699 SPG7 0.61 9.9 0.48 1.91e-20 Multiple myeloma (IgH translocation); LUSC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg18230493 chr5:56204884 C5orf35 -0.55 -8.61 -0.43 2.9e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs6723226 0.750 rs10182170 chr2:32704186 G/A cg02381751 chr2:32503542 YIPF4 0.62 9.45 0.46 5.93e-19 Intelligence (multi-trait analysis); LUSC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg00999904 chr2:3704751 ALLC -0.43 -6.67 -0.34 1.06e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs877282 0.733 rs11253342 chr10:765072 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -8.46 -0.42 8.5e-16 Personality dimensions; LUSC cis rs2637266 0.507 rs2451911 chr10:78283023 T/C cg18941641 chr10:78392320 NA 0.31 5.75 0.3 1.97e-8 Pulmonary function; LUSC cis rs3806843 1.000 rs6885319 chr5:140200611 A/C cg19875535 chr5:140030758 IK 0.46 7.32 0.37 1.91e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs6570726 1.000 rs951143 chr6:145932576 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.1 0.32 2.98e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.17 0.58 3.48e-32 Platelet count; LUSC trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg08975724 chr8:8085496 FLJ10661 0.41 6.08 0.32 3.28e-9 Neuroticism; LUSC cis rs3744061 0.557 rs9907925 chr17:74646293 G/A cg27546012 chr17:74684504 MXRA7 -0.37 -6.4 -0.33 5.36e-10 Retinal arteriolar caliber; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg04246999 chr16:71930048 KIAA0174 0.39 6.08 0.32 3.3e-9 N-glycan levels; LUSC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg25036284 chr2:26402008 FAM59B -0.68 -9.51 -0.46 3.97e-19 Gut microbiome composition (summer); LUSC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg07507251 chr3:52567010 NT5DC2 0.33 6.53 0.34 2.38e-10 Bipolar disorder; LUSC cis rs35000415 0.938 rs12535158 chr7:128625019 C/T cg19972273 chr7:128594194 NA 0.68 6.9 0.35 2.56e-11 Systemic lupus erythematosus; LUSC cis rs12908161 0.959 rs34342559 chr15:85331271 A/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.5 0.34 2.86e-10 Schizophrenia; LUSC cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg26384229 chr12:38710491 ALG10B 0.86 14.0 0.61 2.4e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg16339924 chr4:17578868 LAP3 0.57 8.63 0.43 2.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg13319975 chr6:146136371 FBXO30 0.47 7.23 0.37 3.28e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2797160 1.000 rs1612249 chr6:126014916 C/A cg05901451 chr6:126070800 HEY2 0.57 8.56 0.42 4.23e-16 Endometrial cancer; LUSC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg07959070 chr22:50026188 C22orf34 -0.34 -6.98 -0.36 1.59e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs681343 1.000 rs492602 chr19:49206417 A/G cg21064579 chr19:49206444 FUT2 0.45 8.61 0.43 2.84e-16 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; LUSC cis rs1577917 0.771 rs9362232 chr6:86353622 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -7.04 -0.36 1.1e-11 Response to antipsychotic treatment; LUSC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs7312933 0.558 rs3747560 chr12:42719890 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.84 -0.35 3.74e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.49 0.42 6.84e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7851660 0.967 rs13288000 chr9:100608980 A/G cg13688889 chr9:100608707 NA -0.61 -10.7 -0.51 3.65e-23 Strep throat; LUSC cis rs1865760 0.602 rs9467662 chr6:26021327 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 7.03 0.36 1.19e-11 Height; LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg22907277 chr7:1156413 C7orf50 0.68 7.36 0.37 1.46e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3020736 0.500 rs8143153 chr22:42515637 G/C cg05082376 chr22:42548792 NA 0.43 6.59 0.34 1.73e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg15704280 chr7:45808275 SEPT13 -1.08 -19.9 -0.74 1.14e-58 Coronary artery disease; LUSC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg13114125 chr14:105738426 BRF1 -0.91 -15.93 -0.66 7.02e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs478304 0.651 rs7110576 chr11:65512057 T/G cg05805236 chr11:65401703 PCNXL3 -0.56 -9.1 -0.45 8.47e-18 Acne (severe); LUSC cis rs17407555 0.647 rs55811736 chr4:10014221 G/A cg00071950 chr4:10020882 SLC2A9 -0.51 -6.15 -0.32 2.2e-9 Schizophrenia (age at onset); LUSC cis rs10100465 0.883 rs10283125 chr8:118644818 A/G cg09430518 chr8:118662568 NA -0.3 -5.9 -0.31 8.92e-9 Leprosy; LUSC cis rs6840360 0.571 rs11723395 chr4:152524191 G/A cg22705602 chr4:152727874 NA -0.33 -6.61 -0.34 1.53e-10 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg11102782 chr19:18549136 ISYNA1 -0.37 -6.96 -0.36 1.83e-11 Breast cancer; LUSC cis rs11690935 0.595 rs788170 chr2:172919958 T/C cg13550731 chr2:172543902 DYNC1I2 0.57 8.97 0.44 2.12e-17 Schizophrenia; LUSC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg16615211 chr3:44902933 MIR564;TMEM42 0.36 6.35 0.33 6.91e-10 Depressive symptoms; LUSC cis rs1568889 0.838 rs10835299 chr11:28277693 A/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.74 -12.74 -0.57 1.45e-30 Bipolar disorder; LUSC cis rs10782582 0.609 rs78748984 chr1:76340467 G/A cg03433033 chr1:76189801 ACADM -0.43 -6.24 -0.32 1.33e-9 Daytime sleep phenotypes; LUSC cis rs921968 0.509 rs832813 chr2:219354569 T/C cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs7215564 0.908 rs35128297 chr17:78652909 A/C cg23238734 chr17:78661607 RPTOR 0.48 6.13 0.32 2.5e-9 Myopia (pathological); LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg03538708 chr1:25844672 NA -0.36 -5.97 -0.31 5.96e-9 Erythrocyte sedimentation rate; LUSC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg05234568 chr11:5960015 NA -0.57 -8.29 -0.41 2.82e-15 DNA methylation (variation); LUSC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg12751644 chr20:60527061 NA -0.35 -6.07 -0.32 3.43e-9 Body mass index; LUSC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg18876405 chr7:65276391 NA -0.59 -9.61 -0.47 1.87e-19 Aortic root size; LUSC cis rs826838 0.935 rs11169511 chr12:39175802 T/C cg13010199 chr12:38710504 ALG10B 0.7 11.97 0.55 1.04e-27 Heart rate; LUSC cis rs2070997 0.667 rs7869508 chr9:133716802 T/C cg11464064 chr9:133710261 ABL1 0.48 5.65 0.3 3.47e-8 Response to amphetamines; LUSC cis rs7000551 0.725 rs1075534 chr8:22374074 A/G cg12081754 chr8:22256438 SLC39A14 0.42 6.42 0.33 4.67e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg23093090 chr10:104574429 C10orf26 -0.43 -7.67 -0.39 1.86e-13 Arsenic metabolism; LUSC cis rs1035144 0.505 rs6574617 chr14:81457615 G/A cg06600135 chr14:81408086 NA -0.61 -8.72 -0.43 1.29e-16 Male sexual orientation; LUSC cis rs644799 0.710 rs1852535 chr11:95501241 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.15 0.58 4.24e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg23985595 chr17:80112537 CCDC57 -0.33 -6.5 -0.33 2.99e-10 Life satisfaction; LUSC cis rs6570726 0.967 rs413880 chr6:145804822 G/A cg23711669 chr6:146136114 FBXO30 0.71 12.38 0.56 3.16e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg07343612 chr16:622815 PIGQ -0.73 -12.51 -0.56 1.07e-29 Height; LUSC cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg15997130 chr1:24165203 NA -0.37 -5.72 -0.3 2.36e-8 Immature fraction of reticulocytes; LUSC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs10979 1.000 rs11155300 chr6:143894576 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.25 -0.56 9.15e-29 Hypospadias; LUSC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg20933634 chr6:27740509 NA 0.4 5.87 0.31 1.06e-8 Parkinson's disease; LUSC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg15445000 chr17:37608096 MED1 -0.41 -7.02 -0.36 1.21e-11 Glomerular filtration rate (creatinine); LUSC cis rs1967309 0.604 rs8061182 chr16:4070333 A/G cg00061520 chr16:4070371 ADCY9 0.4 8.23 0.41 4.37e-15 Response to Dalcetrapib treatment in acute coronary syndrome; LUSC cis rs2179367 0.600 rs9498354 chr6:149762851 A/G cg07828024 chr6:149772892 ZC3H12D 0.33 5.72 0.3 2.4e-8 Dupuytren's disease; LUSC cis rs9616064 0.506 rs3747255 chr22:47074281 G/A cg25730555 chr22:47059586 GRAMD4 0.46 7.0 0.36 1.4e-11 Urate levels in obese individuals; LUSC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg00071950 chr4:10020882 SLC2A9 -0.52 -7.93 -0.4 3.4e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg12863693 chr15:85201151 NMB -0.25 -5.74 -0.3 2.12e-8 P wave terminal force; LUSC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg02951883 chr7:2050386 MAD1L1 0.48 8.65 0.43 2.26e-16 Bipolar disorder and schizophrenia; LUSC cis rs859767 0.501 rs6724777 chr2:135407292 C/T cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Neuroticism; LUSC cis rs868036 0.958 rs11635424 chr15:68037578 C/T cg08079166 chr15:68083412 MAP2K5 0.41 8.31 0.41 2.51e-15 Restless legs syndrome; LUSC cis rs2046867 0.818 rs17010188 chr3:72870351 T/C cg25664220 chr3:72788482 NA -0.7 -12.03 -0.55 6.24e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs354225 0.597 rs10176445 chr2:54845776 G/C cg01766943 chr2:54829624 SPTBN1 0.48 7.74 0.39 1.19e-13 Schizophrenia; LUSC cis rs9788682 0.747 rs2568499 chr15:78722359 T/C cg24631222 chr15:78858424 CHRNA5 -0.67 -9.05 -0.44 1.25e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17043366 chr19:8578907 ZNF414 -0.43 -6.54 -0.34 2.33e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12762955 0.561 rs7075141 chr10:1091195 C/T cg20503657 chr10:835505 NA -0.46 -6.63 -0.34 1.37e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg05805236 chr11:65401703 PCNXL3 -0.38 -5.78 -0.3 1.73e-8 Breast cancer; LUSC trans rs7824557 0.628 rs7005469 chr8:11194457 G/A cg06636001 chr8:8085503 FLJ10661 0.43 6.31 0.33 8.77e-10 Retinal vascular caliber; LUSC cis rs11971779 0.680 rs6965212 chr7:139026465 G/T cg07862535 chr7:139043722 LUC7L2 0.59 7.35 0.37 1.58e-12 Diisocyanate-induced asthma; LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg00815214 chr21:47717953 NA -0.36 -5.95 -0.31 6.76e-9 Testicular germ cell tumor; LUSC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg22496380 chr5:211416 CCDC127 -0.71 -8.12 -0.41 9.34e-15 Breast cancer; LUSC cis rs1577917 1.000 rs9647603 chr6:86639341 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg03576123 chr11:487126 PTDSS2 -0.96 -10.61 -0.5 7.48e-23 Body mass index; LUSC trans rs6480314 0.542 rs61854805 chr10:70015583 A/G cg04882175 chr6:131122610 NA -0.55 -6.21 -0.32 1.59e-9 Optic nerve measurement (disc area); LUSC cis rs7312933 0.558 rs3747560 chr12:42719890 A/G cg01256987 chr12:42539512 GXYLT1 0.35 6.4 0.33 5.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg05585544 chr11:47624801 NA -0.41 -7.12 -0.36 6.69e-12 Subjective well-being; LUSC cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg13010199 chr12:38710504 ALG10B -0.69 -11.41 -0.53 1.12e-25 Heart rate; LUSC cis rs7296418 0.738 rs10846489 chr12:123743927 A/G cg05973401 chr12:123451056 ABCB9 -0.56 -8.12 -0.41 9.2e-15 Platelet count; LUSC cis rs887829 0.570 rs10203266 chr2:234596368 G/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.22 -0.32 1.47e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs694739 0.687 rs11231771 chr11:64140642 T/G cg26898376 chr11:64110657 CCDC88B 0.31 5.81 0.3 1.45e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs6547741 0.743 rs7564625 chr2:27862397 C/T cg27432699 chr2:27873401 GPN1 -0.9 -17.64 -0.69 1.13e-49 Oral cavity cancer; LUSC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg06808227 chr14:105710500 BRF1 -0.71 -11.41 -0.53 1.09e-25 Mean platelet volume;Platelet distribution width; LUSC cis rs2933343 0.729 rs1680780 chr3:128612659 G/C cg11901034 chr3:128598214 ACAD9 -0.4 -6.21 -0.32 1.55e-9 IgG glycosylation; LUSC cis rs28374715 0.532 rs11854632 chr15:41682094 A/G cg18705301 chr15:41695430 NDUFAF1 1.03 23.4 0.79 2.27e-72 Ulcerative colitis; LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg14004847 chr7:1930337 MAD1L1 -0.45 -6.59 -0.34 1.73e-10 Bipolar disorder and schizophrenia; LUSC cis rs12618769 1.000 rs3769696 chr2:99258927 A/G cg10123293 chr2:99228465 UNC50 0.43 5.97 0.31 6.09e-9 Bipolar disorder; LUSC cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg26384229 chr12:38710491 ALG10B 0.96 18.51 0.71 3.79e-53 Heart rate; LUSC trans rs8072100 0.840 rs1912482 chr17:45454883 G/A cg03886242 chr7:26192032 NFE2L3 -0.4 -6.48 -0.33 3.34e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11190604 1.000 rs2489051 chr10:102351785 C/T cg07080220 chr10:102295463 HIF1AN -0.64 -8.98 -0.44 2.03e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6964587 1.000 rs7785971 chr7:91736794 T/A cg17063962 chr7:91808500 NA 0.56 8.97 0.44 2.15e-17 Breast cancer; LUSC cis rs12313068 0.656 rs41436646 chr12:110495171 C/G cg12870014 chr12:110450643 ANKRD13A 0.62 9.13 0.45 6.6e-18 Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs416 chr7:91580571 A/G cg01689657 chr7:91764605 CYP51A1 -0.33 -6.06 -0.31 3.68e-9 Breast cancer; LUSC trans rs2736337 0.532 rs6998387 chr8:11293458 C/T cg06636001 chr8:8085503 FLJ10661 0.44 6.02 0.31 4.55e-9 Rheumatoid arthritis; LUSC cis rs11122272 0.733 rs2749700 chr1:231522734 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.32 -0.49 7.43e-22 Hemoglobin concentration; LUSC cis rs4280164 0.708 rs78269053 chr14:24794314 A/G cg16194253 chr14:24768981 DHRS1;C14orf21 -0.59 -7.07 -0.36 9.14e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs981844 1.000 rs2251900 chr4:154654145 C/T cg14289246 chr4:154710475 SFRP2 0.51 6.1 0.32 2.92e-9 Response to statins (LDL cholesterol change); LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg22907277 chr7:1156413 C7orf50 0.63 9.5 0.46 4.15e-19 Longevity;Endometriosis; LUSC cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.93 0.31 7.65e-9 Rheumatoid arthritis; LUSC cis rs394563 0.810 rs480870 chr6:149784818 T/C cg11245181 chr6:149772854 ZC3H12D -0.33 -7.06 -0.36 9.69e-12 Dupuytren's disease; LUSC cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.24 0.49 1.42e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg21252483 chr19:49399788 TULP2 -0.48 -6.77 -0.35 5.81e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs8092503 0.951 rs12457769 chr18:52499801 T/G cg12377874 chr18:52495404 RAB27B 0.32 5.67 0.3 3.12e-8 Childhood body mass index; LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9527 0.590 rs12785223 chr10:104844011 C/T cg04362960 chr10:104952993 NT5C2 -0.62 -9.65 -0.47 1.32e-19 Arsenic metabolism; LUSC cis rs7918232 0.698 rs6482586 chr10:27297829 A/C cg14240646 chr10:27532245 ACBD5 -0.48 -6.04 -0.31 4.14e-9 Breast cancer; LUSC cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg22455342 chr2:225449267 CUL3 0.81 10.78 0.51 1.81e-23 IgE levels in asthmatics (D.p. specific); LUSC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg18252515 chr7:66147081 NA -1.19 -13.55 -0.6 1.25e-33 Diabetic kidney disease; LUSC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg12310025 chr6:25882481 NA 0.49 8.11 0.41 9.49e-15 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.602 rs1727317 chr12:123618942 T/C cg13010344 chr12:123464640 ARL6IP4 -0.49 -5.99 -0.31 5.48e-9 Neutrophil percentage of white cells; LUSC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg21984481 chr17:79567631 NPLOC4 -0.69 -14.08 -0.61 1.09e-35 Eye color traits; LUSC cis rs17641971 0.862 rs341829 chr8:50005758 T/C cg00325661 chr8:49890786 NA -0.39 -5.77 -0.3 1.8e-8 Blood metabolite levels; LUSC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.45 -0.42 9.43e-16 Lung cancer; LUSC cis rs782590 0.967 rs62165172 chr2:55736237 A/G cg03859395 chr2:55845619 SMEK2 0.86 16.11 0.66 1.33e-43 Metabolic syndrome; LUSC cis rs193541 0.502 rs2061511 chr5:122056727 A/G cg19077854 chr5:122220652 SNX24 0.33 6.58 0.34 1.77e-10 Glucose homeostasis traits; LUSC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg05855489 chr10:104503620 C10orf26 -0.71 -10.46 -0.5 2.47e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg08999081 chr20:33150536 PIGU 0.42 7.79 0.39 8.29e-14 Coronary artery disease; LUSC cis rs7100689 0.556 rs6585971 chr10:82145057 G/C cg01528321 chr10:82214614 TSPAN14 0.89 13.59 0.6 8.81e-34 Post bronchodilator FEV1; LUSC cis rs921968 0.541 rs523305 chr2:219402691 T/C cg02176678 chr2:219576539 TTLL4 0.74 14.55 0.62 1.7e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.79 0.6 1.47e-34 Alzheimer's disease; LUSC cis rs1865760 1.000 rs2071297 chr6:25924513 C/G cg16482183 chr6:26056742 HIST1H1C -0.42 -6.2 -0.32 1.64e-9 Height; LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg00149659 chr3:10157352 C3orf10 0.98 14.25 0.61 2.48e-36 Alzheimer's disease; LUSC cis rs6681460 0.528 rs10889629 chr1:67032098 T/A cg02459107 chr1:67143332 SGIP1 0.32 5.68 0.3 2.97e-8 Presence of antiphospholipid antibodies; LUSC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.21 0.37 3.79e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.43 -0.38 8.93e-13 Height; LUSC cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg24812749 chr6:127587940 RNF146 0.92 13.82 0.6 1.13e-34 Breast cancer; LUSC cis rs9419702 0.568 rs9419635 chr10:133546164 C/T cg04492858 chr10:133558786 NA 0.38 6.41 0.33 4.92e-10 Survival in rectal cancer; LUSC cis rs2573652 0.722 rs12914180 chr15:100544416 T/C cg09918751 chr15:100517450 ADAMTS17 -0.3 -5.71 -0.3 2.55e-8 Height; LUSC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg23985595 chr17:80112537 CCDC57 -0.33 -6.34 -0.33 7.62e-10 Life satisfaction; LUSC cis rs7584330 0.554 rs74832280 chr2:238426625 G/A cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC cis rs6942756 0.747 rs692697 chr7:129112576 C/T cg02491457 chr7:128862824 NA 0.39 5.71 0.3 2.45e-8 White matter hyperintensity burden; LUSC cis rs9527 0.590 rs7906754 chr10:104782557 T/C cg05855489 chr10:104503620 C10orf26 0.53 8.11 0.41 9.87e-15 Arsenic metabolism; LUSC cis rs394563 0.810 rs480870 chr6:149784818 T/C cg03678062 chr6:149772716 ZC3H12D -0.36 -7.39 -0.37 1.19e-12 Dupuytren's disease; LUSC cis rs2290416 0.892 rs77370907 chr8:144664975 G/C cg14809332 chr8:144654887 C8orf73 0.52 6.44 0.33 4.15e-10 Attention deficit hyperactivity disorder; LUSC cis rs868036 0.609 rs2045960 chr15:68092079 G/A cg08079166 chr15:68083412 MAP2K5 0.47 8.25 0.41 3.6e-15 Restless legs syndrome; LUSC cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC cis rs1256061 0.603 rs1256045 chr14:64729760 A/C cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs10504073 0.647 rs12156111 chr8:50017328 G/C cg00325661 chr8:49890786 NA 0.62 10.46 0.5 2.4e-22 Blood metabolite ratios; LUSC cis rs9611519 0.808 rs5751074 chr22:41665722 G/A cg03806693 chr22:41940476 POLR3H -0.56 -8.27 -0.41 3.25e-15 Neuroticism; LUSC cis rs3768617 0.510 rs2027078 chr1:183073478 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.87 0.51 9.12e-24 Fuchs's corneal dystrophy; LUSC cis rs714027 0.534 rs140124 chr22:30143693 G/C cg11564601 chr22:30592435 NA 0.34 6.06 0.31 3.61e-9 Lymphocyte counts; LUSC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg14196790 chr5:131705035 SLC22A5 0.37 6.32 0.33 8.31e-10 Blood metabolite levels; LUSC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg18190219 chr22:46762943 CELSR1 -0.62 -6.21 -0.32 1.62e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg14440974 chr22:39074834 NA -0.39 -6.44 -0.33 4.23e-10 Menopause (age at onset); LUSC trans rs61931739 0.500 rs34080094 chr12:34547952 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs12908161 0.960 rs62019463 chr15:85288087 G/A cg17173187 chr15:85201210 NMB 0.5 9.38 0.46 1.01e-18 Schizophrenia; LUSC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.91 -0.31 8.58e-9 Lung cancer; LUSC trans rs6952808 0.792 rs4421257 chr7:1955152 T/C cg04565464 chr8:145669602 NFKBIL2 0.35 5.95 0.31 6.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs9300255 0.679 rs12817892 chr12:123728702 G/A cg13010344 chr12:123464640 ARL6IP4 0.48 5.87 0.31 1.07e-8 Neutrophil percentage of white cells; LUSC cis rs10186029 0.594 rs7594137 chr2:213931662 G/A cg08319019 chr2:214017104 IKZF2 -0.42 -5.94 -0.31 7.33e-9 Systemic sclerosis; LUSC cis rs9388451 0.587 rs1739385 chr6:126099939 G/A cg05901451 chr6:126070800 HEY2 -0.77 -13.31 -0.59 1.02e-32 Brugada syndrome; LUSC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg14830002 chr1:247616686 OR2B11 0.5 8.01 0.4 1.97e-14 Acute lymphoblastic leukemia (childhood); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20516161 chr22:45559322 NUP50 -0.5 -6.57 -0.34 1.93e-10 Hepatitis; LUSC cis rs56399783 0.803 rs17132665 chr7:2802173 T/C cg19731401 chr7:2775893 GNA12 0.7 9.37 0.46 1.08e-18 Childhood ear infection; LUSC cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs1595825 0.786 rs75619425 chr2:198537281 A/G cg00982548 chr2:198649783 BOLL -0.54 -6.77 -0.35 5.79e-11 Ulcerative colitis; LUSC cis rs62408225 0.722 rs766153 chr6:90905047 A/G cg06866423 chr6:90926672 BACH2 0.41 6.44 0.33 4.09e-10 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11758351 1.000 rs78012445 chr6:26195080 G/C cg11342453 chr6:26196699 NA 0.54 5.71 0.3 2.52e-8 Gout;Renal underexcretion gout; LUSC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg22823121 chr1:150693482 HORMAD1 0.48 6.88 0.35 2.93e-11 Melanoma; LUSC cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -1.16 -26.53 -0.82 3.11e-84 Chronic sinus infection; LUSC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.68 0.39 1.75e-13 Vitiligo; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05709362 chr4:113067289 C4orf32 -0.43 -6.39 -0.33 5.63e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7939886 0.920 rs11227434 chr11:55945251 G/T cg03929089 chr4:120376271 NA 0.79 5.95 0.31 6.68e-9 Myopia (pathological); LUSC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg00343127 chr12:129299088 SLC15A4;MGC16384 0.35 5.68 0.3 2.99e-8 Systemic lupus erythematosus; LUSC cis rs4730250 0.634 rs257371 chr7:106795043 C/A cg02696742 chr7:106810147 HBP1 -0.64 -8.94 -0.44 2.79e-17 Osteoarthritis; LUSC cis rs10751667 0.577 rs7946461 chr11:974035 A/G ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.19e-10 Alzheimer's disease (late onset); LUSC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg08798685 chr6:27730294 NA -0.68 -6.14 -0.32 2.37e-9 Depression; LUSC cis rs7241530 0.662 rs7244362 chr18:75906793 T/C cg14642773 chr18:75888474 NA 0.39 5.88 0.31 9.8e-9 Educational attainment (years of education); LUSC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg05855489 chr10:104503620 C10orf26 -0.67 -9.93 -0.48 1.62e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01339255 chr4:141445245 ELMOD2 -0.51 -6.8 -0.35 4.9e-11 Hepatitis; LUSC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg23283495 chr1:209979779 IRF6 -0.52 -8.61 -0.43 2.99e-16 Orofacial clefts; LUSC cis rs548181 0.736 rs543389 chr11:125464841 A/G cg03464685 chr11:125439445 EI24 1.23 14.43 0.62 5.12e-37 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs478304 0.651 rs7110576 chr11:65512057 T/G cg10518572 chr11:65560635 OVOL1 -0.25 -5.66 -0.3 3.25e-8 Acne (severe); LUSC cis rs12681287 0.640 rs12678720 chr8:87457929 T/G cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs74544699 1.000 rs11574452 chr4:74846661 A/C cg05509609 chr4:74847829 PF4 -0.79 -6.06 -0.31 3.65e-9 Growth-regulated protein alpha levels; LUSC cis rs62458065 0.713 rs921406 chr7:32486205 G/C cg20159608 chr7:32802032 NA -0.73 -9.21 -0.45 3.83e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs13401104 0.796 rs1466205 chr2:237121194 A/G cg19324714 chr2:237145437 ASB18 0.44 5.66 0.3 3.34e-8 Educational attainment; LUSC cis rs926392 0.932 rs6513588 chr20:37686281 T/C cg27552599 chr20:37590471 DHX35 0.33 5.77 0.3 1.82e-8 Dialysis-related mortality; LUSC cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg00290607 chr11:67383545 NA -0.36 -6.43 -0.33 4.3e-10 Mean corpuscular volume; LUSC cis rs7580658 0.857 rs2896980 chr2:128139959 T/C cg09760422 chr2:128146352 NA -0.3 -6.36 -0.33 6.57e-10 Protein C levels; LUSC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg07256732 chr16:621771 PIGQ -0.35 -6.33 -0.33 7.69e-10 Height; LUSC cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06544989 chr22:39130855 UNC84B 0.36 6.42 0.33 4.74e-10 Menopause (age at onset); LUSC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg10560079 chr2:191398806 TMEM194B 0.48 7.94 0.4 3.17e-14 Pulse pressure; LUSC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs1775715 0.870 rs10827001 chr10:32229734 C/T cg03015672 chr10:32216066 ARHGAP12 0.33 5.84 0.3 1.25e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9914988 0.832 rs34901720 chr17:27179518 A/G cg09479241 chr17:27052676 TLCD1 0.43 6.09 0.32 3.15e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg20203395 chr5:56204925 C5orf35 -0.78 -10.68 -0.5 4.11e-23 Initial pursuit acceleration; LUSC cis rs11048434 0.723 rs2080116 chr12:9138183 A/G cg23795048 chr12:9217529 LOC144571 0.34 5.83 0.3 1.32e-8 Sjögren's syndrome; LUSC trans rs17133449 0.718 rs11252674 chr10:4753422 C/T cg17844448 chr7:27782764 TAX1BP1 -0.37 -6.08 -0.32 3.3e-9 Major depressive disorder; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs10492096 0.898 rs12426815 chr12:6580314 A/G cg13857086 chr12:6580257 VAMP1 0.67 7.78 0.39 9.44e-14 Hip geometry; LUSC trans rs634534 0.622 rs531612 chr11:65705432 C/T cg17712092 chr4:129076599 LARP1B -0.78 -11.81 -0.54 4.05e-27 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs10911251 0.508 rs2296297 chr1:183105324 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.45 0.5 2.71e-22 Colorectal cancer; LUSC cis rs72781680 1.000 rs12617839 chr2:24166277 A/T cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg02475777 chr4:1388615 CRIPAK 0.42 6.52 0.34 2.6e-10 Longevity; LUSC cis rs6496667 0.600 rs28674812 chr15:91077809 G/T cg03599575 chr15:90893182 GABARAPL3 0.41 5.96 0.31 6.35e-9 Rheumatoid arthritis; LUSC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg26408565 chr15:76604113 ETFA 0.48 7.8 0.39 8.05e-14 Blood metabolite levels; LUSC cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg22676075 chr6:135203613 NA 0.74 13.22 0.59 2.29e-32 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs9929218 0.817 rs3114405 chr16:68722377 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.89 -13.45 -0.59 2.87e-33 Colorectal cancer; LUSC cis rs3125734 0.660 rs4979780 chr10:63992740 A/C cg19640130 chr10:64028056 RTKN2 -0.4 -7.15 -0.36 5.41e-12 Rheumatoid arthritis; LUSC cis rs12618769 0.652 rs17506535 chr2:99222834 G/C cg10123293 chr2:99228465 UNC50 0.47 7.7 0.39 1.59e-13 Bipolar disorder; LUSC cis rs4363385 0.667 rs756303 chr1:152908222 C/T cg07796016 chr1:152779584 LCE1C -0.44 -6.42 -0.33 4.61e-10 Inflammatory skin disease; LUSC cis rs7793919 0.726 rs4720401 chr7:4780943 G/A cg09789173 chr7:4769017 FOXK1 0.65 11.93 0.55 1.48e-27 Mosquito bite size; LUSC cis rs7824557 0.628 rs3779891 chr8:11183505 G/A cg21775007 chr8:11205619 TDH 0.79 13.15 0.58 4.08e-32 Retinal vascular caliber; LUSC cis rs6977660 0.941 rs10273208 chr7:19816371 T/C cg05791153 chr7:19748676 TWISTNB 0.57 6.31 0.33 9.06e-10 Thyroid stimulating hormone; LUSC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg12963246 chr6:28129442 ZNF389 0.4 6.38 0.33 5.91e-10 Parkinson's disease; LUSC cis rs1799949 0.965 rs8071278 chr17:41193910 A/T cg05368731 chr17:41323189 NBR1 0.84 13.7 0.6 3.32e-34 Menopause (age at onset); LUSC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg04352962 chr1:209979756 IRF6 0.52 5.78 0.3 1.72e-8 Coronary artery disease; LUSC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg19346786 chr7:2764209 NA -0.49 -8.08 -0.4 1.21e-14 Height; LUSC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg03452623 chr4:187889614 NA 0.92 18.7 0.72 6.83e-54 Lobe attachment (rater-scored or self-reported); LUSC cis rs6840360 0.967 rs10028961 chr4:152668224 A/G cg22705602 chr4:152727874 NA -0.27 -5.85 -0.3 1.2e-8 Intelligence (multi-trait analysis); LUSC cis rs6500602 0.647 rs4786519 chr16:4584406 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 7.5 0.38 5.69e-13 Schizophrenia; LUSC cis rs1348850 0.750 rs12997716 chr2:178494629 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.78 0.3 1.76e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs225245 0.782 rs321618 chr17:33912404 A/G cg19694781 chr19:47549865 TMEM160 -0.41 -6.61 -0.34 1.51e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.94 0.31 7.17e-9 Menopause (age at onset); LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.69 0.54 1.04e-26 Prudent dietary pattern; LUSC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg17971929 chr21:40555470 PSMG1 -0.51 -7.52 -0.38 5.21e-13 Menarche (age at onset); LUSC cis rs1865721 1.000 rs62089511 chr18:73197629 C/T cg26385618 chr18:73139727 C18orf62 -0.47 -7.9 -0.4 3.94e-14 Intelligence; LUSC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs4780401 0.728 rs7188511 chr16:11773743 G/T cg01061890 chr16:11836724 TXNDC11 -0.47 -6.83 -0.35 4.02e-11 Rheumatoid arthritis; LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.44 0.38 8.5e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02963550 chr12:125256644 NA 0.52 7.28 0.37 2.42e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9430161 0.611 rs12081197 chr1:11034239 T/C cg02454025 chr1:11042201 C1orf127 1.03 18.59 0.71 1.77e-53 Ewing sarcoma; LUSC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs9486719 0.857 rs1157316 chr6:96869710 G/A cg06623918 chr6:96969491 KIAA0776 0.8 11.59 0.54 2.38e-26 Migraine;Coronary artery disease; LUSC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg15448220 chr1:150897856 SETDB1 0.42 6.07 0.32 3.48e-9 Melanoma; LUSC cis rs61931739 0.513 rs10772116 chr12:33897795 G/C cg06521331 chr12:34319734 NA -0.35 -5.7 -0.3 2.61e-8 Morning vs. evening chronotype; LUSC cis rs10736390 1.000 rs11206402 chr1:55104317 G/C cg01517571 chr1:55089959 ACOT11;FAM151A -0.62 -11.74 -0.54 6.76e-27 Survival in pancreatic cancer; LUSC cis rs2580764 0.540 rs10210840 chr2:55226009 G/A cg09592903 chr2:55203963 RTN4 -0.47 -9.59 -0.46 2.12e-19 Mean platelet volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01349858 chr17:75277363 SEPT9 -0.42 -6.34 -0.33 7.25e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.38 0.37 1.24e-12 Bipolar disorder; LUSC cis rs614226 1.000 rs7174 chr12:121017171 A/G cg27489772 chr12:121021490 NA 0.6 7.87 0.4 5.06e-14 Type 1 diabetes nephropathy; LUSC cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -8.23 -0.41 4.2e-15 Chronic sinus infection; LUSC cis rs868036 0.718 rs2241420 chr15:68082816 G/A cg05925327 chr15:68127851 NA -0.41 -6.6 -0.34 1.6e-10 Restless legs syndrome; LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC trans rs7824557 0.628 rs7815802 chr8:11190647 G/C cg06636001 chr8:8085503 FLJ10661 0.43 6.27 0.32 1.12e-9 Retinal vascular caliber; LUSC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg03806693 chr22:41940476 POLR3H 0.97 13.9 0.61 5.68e-35 Vitiligo; LUSC cis rs7923609 0.934 rs10761771 chr10:65230164 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.1e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.45 6.04 0.31 4.01e-9 Renal function-related traits (BUN); LUSC trans rs7824557 0.564 rs2572400 chr8:11234367 T/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.42 -0.33 4.56e-10 Retinal vascular caliber; LUSC cis rs8049040 0.609 rs11866859 chr16:71478888 G/A cg08717414 chr16:71523259 ZNF19 -0.39 -5.65 -0.3 3.39e-8 Blood protein levels; LUSC cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.6e-8 Breast cancer; LUSC cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg09626299 chr10:82213104 TSPAN14 -0.2 -5.87 -0.31 1.03e-8 Post bronchodilator FEV1; LUSC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg08462924 chr1:41848221 NA 0.5 8.55 0.42 4.49e-16 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.626 rs35129566 chr3:49866584 T/G cg03060546 chr3:49711283 APEH -0.64 -7.5 -0.38 5.75e-13 Menarche (age at onset); LUSC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg09455208 chr3:40491958 NA 0.57 10.34 0.49 6.18e-22 Renal cell carcinoma; LUSC cis rs6582630 0.524 rs10785494 chr12:38532431 C/G cg13010199 chr12:38710504 ALG10B -0.43 -6.54 -0.34 2.35e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs13631 0.965 rs9411307 chr9:139994947 C/T cg14395844 chr9:139980277 LOC100289341;MAN1B1 0.45 7.18 0.37 4.65e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.28 0.56 7.31e-29 Prudent dietary pattern; LUSC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.21 17.25 0.69 3.83e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg11492896 chr2:32581942 BIRC6 0.46 5.97 0.31 6.2e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs701145 0.556 rs355787 chr3:153994502 T/C cg17054900 chr3:154042577 DHX36 0.44 5.67 0.3 3.08e-8 Coronary artery disease; LUSC cis rs7582180 0.903 rs7609376 chr2:100905828 A/G cg08017756 chr2:100939284 LONRF2 -0.37 -6.22 -0.32 1.47e-9 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg06636001 chr8:8085503 FLJ10661 -0.59 -8.37 -0.42 1.57e-15 Neuroticism; LUSC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg18404041 chr3:52824283 ITIH1 -0.52 -9.67 -0.47 1.13e-19 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.629 rs11123826 chr2:100936276 G/T cg14675211 chr2:100938903 LONRF2 -0.36 -5.72 -0.3 2.38e-8 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg23711669 chr6:146136114 FBXO30 -0.83 -14.89 -0.63 8.4e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs7707921 0.881 rs73134722 chr5:81326622 G/A cg15871215 chr5:81402204 ATG10 -0.45 -6.68 -0.34 9.93e-11 Breast cancer; LUSC cis rs11626933 1.000 rs3742669 chr14:90767746 C/A cg14092571 chr14:90743983 NA 0.84 17.76 0.7 3.87e-50 Gut microbiota (bacterial taxa); LUSC cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg03676636 chr4:99064102 C4orf37 0.27 5.84 0.3 1.26e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs6710529 1 rs6710529 chr2:219645553 G/A cg02176678 chr2:219576539 TTLL4 -0.56 -9.9 -0.48 1.94e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.82 -0.39 7.07e-14 Personality dimensions; LUSC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg11871910 chr12:69753446 YEATS4 0.84 15.2 0.64 5.09e-40 Blood protein levels; LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg14092988 chr3:52407081 DNAH1 0.31 6.18 0.32 1.82e-9 Bipolar disorder; LUSC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg09365446 chr1:150670422 GOLPH3L 0.55 8.3 0.41 2.68e-15 Tonsillectomy; LUSC cis rs12136530 0.714 rs34553579 chr1:19779378 A/C cg01832549 chr1:19774989 CAPZB -0.32 -5.92 -0.31 7.97e-9 Lead levels in blood; LUSC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg01283332 chr5:1856932 NA -0.33 -6.18 -0.32 1.87e-9 Cardiovascular disease risk factors; LUSC cis rs394563 0.534 rs388335 chr6:149791986 T/C cg07828024 chr6:149772892 ZC3H12D -0.46 -8.95 -0.44 2.51e-17 Dupuytren's disease; LUSC cis rs9527 0.640 rs6584541 chr10:104929124 A/G cg05855489 chr10:104503620 C10orf26 0.52 7.85 0.39 5.83e-14 Arsenic metabolism; LUSC cis rs11098499 0.818 rs10008791 chr4:120431469 A/C cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.72e-25 Corneal astigmatism; LUSC cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg17845761 chr1:175162550 KIAA0040 0.31 5.9 0.31 8.94e-9 Alcohol dependence; LUSC cis rs6545883 0.860 rs6749226 chr2:61509783 G/A cg15711740 chr2:61764176 XPO1 0.44 6.71 0.34 8.14e-11 Tuberculosis; LUSC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg00129232 chr17:37814104 STARD3 -0.49 -7.28 -0.37 2.35e-12 Asthma; LUSC cis rs7582180 0.715 rs920270 chr2:100917961 T/C cg12002119 chr2:101014098 CHST10 0.37 6.26 0.32 1.2e-9 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.962 rs2314130 chr20:61665129 G/T cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs12410462 0.582 rs12408978 chr1:227596235 A/T cg23173402 chr1:227635558 NA -0.62 -7.26 -0.37 2.67e-12 Major depressive disorder; LUSC cis rs240764 0.817 rs239230 chr6:101105862 C/A cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg02782426 chr3:40428986 ENTPD3 0.36 6.8 0.35 4.77e-11 Renal cell carcinoma; LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg13685833 chr1:53393034 SCP2 0.4 6.0 0.31 5.27e-9 Monocyte count; LUSC cis rs921968 0.540 rs646295 chr2:219408558 A/C cg02176678 chr2:219576539 TTLL4 0.64 11.82 0.54 3.72e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.74 -0.35 6.93e-11 Breast cancer; LUSC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22307029 chr19:49891270 CCDC155 0.61 7.78 0.39 9.21e-14 Multiple sclerosis; LUSC cis rs3741151 0.687 rs7933355 chr11:73236817 G/C cg17517138 chr11:73019481 ARHGEF17 0.9 7.63 0.39 2.41e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg06481639 chr22:41940642 POLR3H 0.5 5.69 0.3 2.8e-8 Vitiligo; LUSC cis rs4680 1.000 rs165722 chr22:19949013 C/T cg23601416 chr22:19950040 COMT 0.32 6.69 0.34 9.69e-11 Blood metabolite levels; LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg14004847 chr7:1930337 MAD1L1 -0.5 -7.58 -0.38 3.54e-13 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.68 0.39 1.75e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg00944433 chr1:107599041 PRMT6 -0.36 -6.68 -0.34 1.02e-10 Facial morphology (factor 21, depth of nasal alae); LUSC trans rs2262909 0.962 rs11669110 chr19:22296485 A/G cg17074339 chr11:11642133 GALNTL4 0.43 6.53 0.34 2.45e-10 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6546537 0.824 rs13011186 chr2:69778558 C/T cg10773587 chr2:69614142 GFPT1 -0.63 -10.28 -0.49 9.87e-22 Serum thyroid-stimulating hormone levels; LUSC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg09165964 chr15:75287851 SCAMP5 0.51 7.5 0.38 5.66e-13 Breast cancer; LUSC cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg22601191 chr20:60968625 CABLES2 -0.4 -5.79 -0.3 1.58e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs981844 0.743 rs17371461 chr4:154759220 C/T cg14289246 chr4:154710475 SFRP2 0.49 6.62 0.34 1.44e-10 Response to statins (LDL cholesterol change); LUSC cis rs1003719 0.667 rs6517404 chr21:38494918 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.65 10.52 0.5 1.48e-22 Eye color traits; LUSC cis rs9902453 0.904 rs4994353 chr17:28386280 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.54 -8.11 -0.41 9.96e-15 Coffee consumption (cups per day); LUSC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg04369109 chr6:150039330 LATS1 0.62 9.24 0.45 2.95e-18 Lung cancer; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg27588902 chr6:42928151 GNMT -0.3 -6.54 -0.34 2.29e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg07507251 chr3:52567010 NT5DC2 0.33 6.31 0.33 9.09e-10 Bipolar disorder; LUSC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.57 0.5 9.83e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6700896 0.931 rs12042779 chr1:66133950 T/C cg04111102 chr1:66153794 NA 0.33 7.23 0.37 3.41e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.48 -0.42 7.27e-16 Height; LUSC cis rs10865541 0.902 rs6739163 chr2:3419011 G/A cg15807143 chr2:3452624 TTC15 0.32 5.66 0.3 3.3e-8 Obesity-related traits; LUSC cis rs12540874 0.698 rs13234331 chr7:50560314 G/T cg18232548 chr7:50535776 DDC -0.62 -9.27 -0.45 2.39e-18 Systemic sclerosis; LUSC cis rs12410462 0.681 rs6670816 chr1:227610592 G/T cg10327440 chr1:227177885 CDC42BPA 0.63 5.93 0.31 7.62e-9 Major depressive disorder; LUSC cis rs477692 1.000 rs558764 chr10:131426957 G/T cg05714579 chr10:131428358 MGMT -0.51 -7.62 -0.38 2.7e-13 Response to temozolomide; LUSC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg10169327 chr19:45448959 APOC2 0.3 6.57 0.34 1.93e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12477438 0.520 rs12467504 chr2:99543208 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.54 -6.57 -0.34 1.89e-10 Chronic sinus infection; LUSC cis rs9324022 0.929 rs72698718 chr14:101178555 G/A cg18089426 chr14:101175970 NA 0.46 5.65 0.3 3.45e-8 Plateletcrit; LUSC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.86e-11 Aortic root size; LUSC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.68 0.54 1.16e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg11244672 chr19:19639970 YJEFN3 -0.57 -7.08 -0.36 8.82e-12 Bipolar disorder; LUSC trans rs8002861 0.934 rs9533685 chr13:44468331 A/G cg12856521 chr11:46389249 DGKZ 0.41 6.31 0.33 9.07e-10 Leprosy; LUSC cis rs644799 0.710 rs3017756 chr11:95537358 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.51 0.59 1.77e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12594515 1.000 rs8033148 chr15:45997929 G/A cg06207120 chr15:45996521 NA 0.39 6.04 0.31 4.12e-9 Waist circumference;Weight; LUSC cis rs10887741 1.000 rs12761361 chr10:89427203 G/C cg13926569 chr10:89418898 PAPSS2 0.34 6.84 0.35 3.87e-11 Exercise (leisure time); LUSC cis rs7809950 0.862 rs2299421 chr7:106946195 C/G cg23024343 chr7:107201750 COG5 -0.5 -7.96 -0.4 2.78e-14 Coronary artery disease; LUSC cis rs34779708 0.931 rs66887762 chr10:35330577 C/T cg04310649 chr10:35416472 CREM -0.43 -6.48 -0.33 3.21e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg24642439 chr20:33292090 TP53INP2 0.53 8.13 0.41 8.37e-15 Coronary artery disease; LUSC cis rs1506636 1.000 rs644958 chr7:123400873 C/T cg03229431 chr7:123269106 ASB15 0.64 10.65 0.5 5.57e-23 Plateletcrit;Platelet count; LUSC trans rs10432489 0.541 rs6724902 chr2:181739323 A/T cg00055848 chr2:62422984 B3GNT2 -0.88 -6.24 -0.32 1.33e-9 QT interval; LUSC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg05340658 chr4:99064831 C4orf37 -0.66 -11.36 -0.53 1.65e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg08999081 chr20:33150536 PIGU -0.54 -10.72 -0.51 3.14e-23 Glomerular filtration rate (creatinine); LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.61 0.34 1.5e-10 Menopause (age at onset); LUSC cis rs314370 1.000 rs314370 chr7:100453208 T/C cg10426581 chr7:100472382 SRRT 0.86 12.43 0.56 2.07e-29 Resting heart rate; LUSC trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg15704280 chr7:45808275 SEPT13 -1.06 -20.24 -0.74 5.01e-60 Coronary artery disease; LUSC cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg16240275 chr20:61666158 NCRNA00029 0.37 7.0 0.36 1.45e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs8017423 0.904 rs2149647 chr14:90769539 C/T cg04374321 chr14:90722782 PSMC1 -0.67 -10.03 -0.48 7.2e-21 Mortality in heart failure; LUSC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.61e-8 Diabetic kidney disease; LUSC cis rs10186029 0.657 rs11689895 chr2:213938553 G/T cg08319019 chr2:214017104 IKZF2 0.57 8.25 0.41 3.73e-15 Systemic sclerosis; LUSC cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg25233709 chr10:116636983 FAM160B1 0.42 7.55 0.38 4.26e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.52 0.53 4.44e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14067052 chr2:73460340 CCT7;C2orf7 -0.41 -6.1 -0.32 2.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs523522 0.962 rs670568 chr12:121021206 C/T cg27279351 chr12:120934652 DYNLL1 0.66 8.97 0.44 2.22e-17 High light scatter reticulocyte count; LUSC cis rs968567 0.539 rs174560 chr11:61581764 T/C cg19610905 chr11:61596333 FADS2 -0.52 -7.66 -0.39 1.98e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.76 -0.3 1.92e-8 Developmental language disorder (linguistic errors); LUSC cis rs78579285 0.584 rs35353288 chr16:88800814 G/A cg01900006 chr16:88814613 FAM38A 0.61 6.83 0.35 4.14e-11 Joint mobility (Beighton score); LUSC cis rs7264396 0.790 rs6060541 chr20:34248066 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.82 -0.47 3.7e-20 Total cholesterol levels; LUSC cis rs11630290 1.000 rs72750990 chr15:64005333 C/T cg12036633 chr15:63758958 NA -0.73 -8.15 -0.41 7.26e-15 Iris characteristics; LUSC trans rs17266958 1.000 rs17083746 chr9:83292800 G/C cg01905489 chr1:26616534 UBXN11 -0.59 -6.46 -0.33 3.65e-10 Preschool internalizing problems; LUSC cis rs2548003 0.518 rs13157411 chr5:28751609 C/T cg22863700 chr5:28928346 NA -0.42 -5.74 -0.3 2.08e-8 Hip geometry; LUSC cis rs870825 0.616 rs7659201 chr4:185632013 G/A cg04058563 chr4:185651563 MLF1IP 0.87 13.33 0.59 8.18e-33 Blood protein levels; LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs6479891 0.524 rs10740107 chr10:64944317 T/A cg10211456 chr7:963471 ADAP1 0.42 6.09 0.32 3.04e-9 Arthritis (juvenile idiopathic); LUSC cis rs56346965 0.506 rs929566 chr2:191521441 C/G cg11845111 chr2:191398756 TMEM194B -0.46 -6.22 -0.32 1.51e-9 Bone mineral density (Ward's triangle area); LUSC cis rs7178572 0.524 rs2175941 chr15:77584498 T/C cg22256960 chr15:77711686 NA -0.5 -8.02 -0.4 1.83e-14 Type 2 diabetes; LUSC cis rs6669919 0.565 rs10863911 chr1:211686860 C/T cg10512769 chr1:211675356 NA -0.24 -5.7 -0.3 2.64e-8 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg17279839 chr7:150038598 RARRES2 0.43 6.58 0.34 1.81e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs459571 0.959 rs410876 chr9:136893867 C/A cg13789015 chr9:136890014 NCRNA00094 0.69 12.51 0.56 9.97e-30 Platelet distribution width; LUSC cis rs10392 0.516 rs3752293 chr20:37570725 A/G cg27552599 chr20:37590471 DHX35 -0.43 -6.94 -0.35 2.05e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs908922 0.676 rs4845788 chr1:152519496 T/C cg20991723 chr1:152506922 NA 0.53 9.94 0.48 1.42e-20 Hair morphology; LUSC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg13628971 chr7:2884303 GNA12 0.49 6.82 0.35 4.33e-11 Height; LUSC cis rs9611565 0.506 rs7364221 chr22:41650190 C/A cg13813247 chr22:41461852 NA -0.32 -5.99 -0.31 5.48e-9 Vitiligo; LUSC cis rs7598759 0.584 rs4973409 chr2:232311871 C/T cg19187155 chr2:232395269 NMUR1 0.39 5.71 0.3 2.49e-8 Noise-induced hearing loss; LUSC cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.71 -0.34 8.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9653442 0.593 rs6542920 chr2:100845088 A/G cg07810366 chr2:100720526 AFF3 -0.37 -6.01 -0.31 4.77e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs362272 0.524 rs6819202 chr4:3368264 G/A cg14583973 chr4:3374767 RGS12 0.37 7.83 0.39 6.56e-14 Serum sulfate level; LUSC cis rs11758351 1.000 rs16891405 chr6:26204506 A/G cg01420254 chr6:26195488 NA 0.68 7.39 0.37 1.2e-12 Gout;Renal underexcretion gout; LUSC cis rs11148252 0.875 rs4884452 chr13:52949784 C/T cg00495681 chr13:53174319 NA -0.52 -8.46 -0.42 8.25e-16 Lewy body disease; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.25 0.45 2.66e-18 Prudent dietary pattern; LUSC cis rs870825 0.616 rs28490461 chr4:185651638 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.42 0.56 2.15e-29 Blood protein levels; LUSC cis rs1577917 1.000 rs35760725 chr6:86648985 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg01206211 chr2:36825736 FEZ2 0.51 10.3 0.49 9.01e-22 Height; LUSC cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg18681998 chr4:17616180 MED28 0.77 13.38 0.59 5.42e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg07414643 chr4:187882934 NA 0.55 10.53 0.5 1.41e-22 Lobe attachment (rater-scored or self-reported); LUSC trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9814567 0.727 rs7641798 chr3:134345719 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.86 -0.58 5.11e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg20607287 chr7:12443886 VWDE -0.58 -6.01 -0.31 4.81e-9 Coronary artery disease; LUSC cis rs8058578 0.945 rs885107 chr16:30672719 T/C cg05768032 chr16:30646687 NA 0.41 5.96 0.31 6.29e-9 Multiple myeloma; LUSC cis rs12893668 0.703 rs8017993 chr14:104047734 A/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -6.24 -0.32 1.33e-9 Reticulocyte count; LUSC cis rs765787 0.530 rs12440238 chr15:45512905 T/C cg25801113 chr15:45476975 SHF -0.34 -6.71 -0.34 8.19e-11 Uric acid levels; LUSC cis rs26868 0.690 rs26835 chr16:2237549 C/T cg02248941 chr16:2239361 CASKIN1 0.53 10.22 0.49 1.68e-21 Height; LUSC cis rs1983891 1.000 rs6458228 chr6:41543793 C/A cg20194872 chr6:41519635 FOXP4 0.37 6.49 0.33 3.11e-10 Prostate cancer; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg21856205 chr7:94953877 PON1 0.44 8.35 0.42 1.8e-15 Paraoxonase activity; LUSC cis rs11696845 0.626 rs6073537 chr20:43378270 A/G cg25301532 chr20:43378953 KCNK15 -0.35 -6.2 -0.32 1.62e-9 Obesity-related traits; LUSC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg21782813 chr7:2030301 MAD1L1 0.45 7.39 0.37 1.21e-12 Schizophrenia; LUSC cis rs8078723 0.668 rs3859192 chr17:38128648 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.49 -8.18 -0.41 6.01e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18601261 chr12:27397137 STK38L 0.72 5.96 0.31 6.35e-9 Cognitive performance; LUSC cis rs1790761 0.967 rs12787021 chr11:67204342 A/G cg24690094 chr11:67383802 NA -0.32 -5.88 -0.31 9.69e-9 Mean corpuscular volume; LUSC cis rs1401999 0.690 rs1402001 chr3:183642751 A/G cg05044414 chr3:183734942 ABCC5 0.21 7.39 0.38 1.15e-12 Anterior chamber depth; LUSC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg19592336 chr6:28129416 ZNF389 0.46 6.01 0.31 4.81e-9 Depression; LUSC trans rs62103177 0.759 rs7227794 chr18:77610925 C/T cg05926928 chr17:57297772 GDPD1 1.49 19.18 0.72 8.55e-56 Opioid sensitivity; LUSC cis rs7254114 0.578 rs7246614 chr19:11310538 C/T cg02815516 chr19:11306319 KANK2 -0.4 -8.18 -0.41 6.06e-15 Immature fraction of reticulocytes; LUSC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.3 0.53 2.82e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4969178 0.932 rs3744219 chr17:76400236 G/A cg05887092 chr17:76393375 PGS1 0.51 9.08 0.44 9.91e-18 HDL cholesterol levels; LUSC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs34638657 0.702 rs67612167 chr16:82199598 A/G cg09439754 chr16:82129088 HSD17B2 -0.39 -6.47 -0.33 3.49e-10 Lung adenocarcinoma; LUSC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg09165964 chr15:75287851 SCAMP5 -1.17 -19.78 -0.73 3.41e-58 Blood trace element (Zn levels); LUSC cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.55e-12 Motion sickness; LUSC cis rs1957429 0.614 rs72625640 chr14:65333231 G/A cg23373153 chr14:65346875 NA -0.87 -7.57 -0.38 3.78e-13 Pediatric areal bone mineral density (radius); LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.63 0.6 6.19e-34 Platelet count; LUSC cis rs9815354 0.812 rs113144620 chr3:42008312 A/G cg03022575 chr3:42003672 ULK4 0.82 8.57 0.42 3.93e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs12545109 0.800 rs2670053 chr8:57421998 A/T cg09654669 chr8:57350985 NA -0.55 -7.62 -0.38 2.73e-13 Obesity-related traits; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.47 -8.12 -0.41 8.96e-15 Lymphocyte counts; LUSC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.28 -0.45 2.23e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs921968 0.565 rs13408427 chr2:219628389 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.25 -0.49 1.29e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.57 0.38 3.63e-13 Multiple sclerosis; LUSC trans rs71435601 0.628 rs541569 chr2:21398768 G/A cg20757404 chr19:378427 NA 0.37 6.01 0.31 4.87e-9 Cholesterol, total; LUSC cis rs4356932 0.688 rs59291856 chr4:76970801 T/C cg00809888 chr4:76862425 NAAA 0.34 5.68 0.3 2.94e-8 Blood protein levels; LUSC cis rs2797160 0.547 rs4144549 chr6:125945251 C/G cg05901451 chr6:126070800 HEY2 0.41 5.92 0.31 7.85e-9 Endometrial cancer; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13283942 chr1:153606541 S100A13;C1orf77 0.34 5.99 0.31 5.32e-9 Asthma; LUSC cis rs939658 0.776 rs869672 chr15:79430860 G/A cg17916960 chr15:79447300 NA -0.52 -10.24 -0.49 1.39e-21 Refractive error; LUSC cis rs10392 0.543 rs3752292 chr20:37570475 G/A cg27552599 chr20:37590471 DHX35 0.43 7.1 0.36 7.47e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs2204008 0.837 rs8189467 chr12:38241956 T/C cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.73e-9 Bladder cancer; LUSC cis rs7980687 0.627 rs1727325 chr12:123698332 G/C cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs4332037 1.000 rs6947019 chr7:1950337 G/A cg23422044 chr7:1970798 MAD1L1 -0.66 -7.4 -0.38 1.11e-12 Bipolar disorder; LUSC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg15448220 chr1:150897856 SETDB1 0.41 6.02 0.31 4.48e-9 Melanoma; LUSC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs2282032 0.527 rs3742666 chr14:90767860 T/C cg04374321 chr14:90722782 PSMC1 0.44 6.09 0.32 3.08e-9 Longevity; LUSC trans rs3857536 0.785 rs1935895 chr6:66936606 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs2398893 0.960 rs11788176 chr9:96829243 C/T cg14459158 chr9:96720562 NA 0.33 6.2 0.32 1.68e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg09997546 chr11:8931473 C11orf17;ST5 -0.42 -8.82 -0.43 6.26e-17 Hemoglobin concentration; LUSC cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg08999081 chr20:33150536 PIGU 0.52 10.19 0.49 2.04e-21 Glomerular filtration rate (creatinine); LUSC cis rs2625529 0.761 rs3743224 chr15:72466799 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.49 -0.38 6.36e-13 Red blood cell count; LUSC cis rs1448094 0.935 rs11117108 chr12:86322310 T/A cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.31e-9 Major depressive disorder; LUSC cis rs60015123 1.000 rs3764031 chr12:7091918 C/T cg26269324 chr12:6977084 TPI1 0.79 5.73 0.3 2.25e-8 Red cell distribution width; LUSC cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.84 12.55 0.57 7.18e-30 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4664304 0.966 rs925411 chr2:160745785 G/T cg23995753 chr2:160760732 LY75 -0.31 -5.77 -0.3 1.84e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9311676 0.656 rs4399910 chr3:58389809 A/G cg26110898 chr3:58419937 PDHB 0.39 6.38 0.33 6.08e-10 Systemic lupus erythematosus; LUSC cis rs4917833 0.752 rs10883101 chr10:100219916 A/G cg19043522 chr10:100227446 HPSE2 0.4 5.71 0.3 2.53e-8 Pediatric bone mineral density (femoral neck); LUSC cis rs11190604 1.000 rs10786596 chr10:102282126 C/A cg23241863 chr10:102295624 HIF1AN 0.48 6.01 0.31 4.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg22467129 chr15:76604101 ETFA -0.42 -6.64 -0.34 1.28e-10 Blood metabolite levels; LUSC cis rs870825 0.698 rs2696046 chr4:185599972 G/A cg04058563 chr4:185651563 MLF1IP -0.79 -11.66 -0.54 1.4e-26 Blood protein levels; LUSC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs5771069 0.669 rs137879 chr22:50457041 C/T cg03721641 chr22:50451245 IL17REL 0.29 5.74 0.3 2.18e-8 Ulcerative colitis; LUSC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg17300311 chr20:3026576 MRPS26 0.47 6.24 0.32 1.33e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs72781680 0.821 rs72796325 chr2:24134537 G/A cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg24813613 chr7:1882135 MAD1L1 -0.43 -7.47 -0.38 7.07e-13 Bipolar disorder and schizophrenia; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 14.04 0.61 1.61e-35 Platelet count; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg17178900 chr1:205818956 PM20D1 0.74 11.91 0.55 1.62e-27 Menarche (age at onset); LUSC cis rs1904096 0.506 rs11097408 chr4:95165662 T/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.17 -0.41 6.47e-15 Type 2 diabetes; LUSC cis rs614226 1.000 rs12310837 chr12:120880572 C/T cg27489772 chr12:121021490 NA 0.52 6.75 0.35 6.37e-11 Type 1 diabetes nephropathy; LUSC cis rs17270561 0.579 rs10456326 chr6:25919662 G/A cg17042849 chr6:26104293 HIST1H4C -0.57 -6.64 -0.34 1.27e-10 Iron status biomarkers; LUSC trans rs3942852 0.868 rs11039514 chr11:48109598 A/G cg15704280 chr7:45808275 SEPT13 -0.55 -6.28 -0.32 1.03e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs12681287 0.752 rs12548328 chr8:87311219 G/A cg27223183 chr8:87520930 FAM82B -0.47 -5.78 -0.3 1.7e-8 Caudate activity during reward; LUSC cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg05347473 chr6:146136440 FBXO30 0.53 8.88 0.44 4.06e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.52 -8.01 -0.4 1.92e-14 Colorectal cancer; LUSC cis rs11190604 1.000 rs10786597 chr10:102291287 C/T cg07080220 chr10:102295463 HIF1AN 0.7 9.4 0.46 8.73e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9560113 1.000 rs9560105 chr13:112175363 A/T cg14154082 chr13:112174009 NA -0.41 -8.28 -0.41 2.94e-15 Menarche (age at onset); LUSC cis rs1577917 0.958 rs11756510 chr6:86699794 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.89 -0.35 2.72e-11 Response to antipsychotic treatment; LUSC cis rs735396 0.770 rs1169314 chr12:121443116 A/G cg02403541 chr12:121454288 C12orf43 0.7 10.19 0.49 2.06e-21 N-glycan levels; LUSC cis rs4363385 0.818 rs2787629 chr1:153011966 A/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg02711726 chr17:80685570 FN3KRP -0.4 -6.09 -0.32 3.17e-9 Glycated hemoglobin levels; LUSC cis rs12200782 0.799 rs72845515 chr6:26646871 A/G cg11502198 chr6:26597334 ABT1 -0.74 -5.77 -0.3 1.8e-8 Small cell lung carcinoma; LUSC cis rs6489882 0.867 rs4766665 chr12:113363109 T/C cg20102336 chr12:113376681 OAS3 -0.42 -5.93 -0.31 7.36e-9 Chronic lymphocytic leukemia; LUSC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -7.92 -0.4 3.51e-14 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg06481639 chr22:41940642 POLR3H -0.52 -5.86 -0.31 1.09e-8 Vitiligo; LUSC cis rs2797160 1.000 rs1739376 chr6:126012084 C/G cg05901451 chr6:126070800 HEY2 0.52 7.89 0.4 4.42e-14 Endometrial cancer; LUSC cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg23711669 chr6:146136114 FBXO30 0.88 16.1 0.66 1.48e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9399135 1.000 rs11754265 chr6:135356216 C/G cg24558204 chr6:135376177 HBS1L 0.6 9.13 0.45 6.69e-18 Red blood cell count; LUSC cis rs2730245 0.527 rs842695 chr7:158662182 G/A cg24397884 chr7:158709396 WDR60 0.8 9.35 0.46 1.28e-18 Height; LUSC cis rs4629710 0.592 rs9492864 chr6:131531306 A/T cg12700074 chr6:131571435 AKAP7 -0.37 -6.01 -0.31 4.9e-9 Multiple myeloma (IgH translocation); LUSC cis rs1322512 0.917 rs2623945 chr6:152961207 A/C cg27316956 chr6:152958899 SYNE1 0.36 5.84 0.3 1.23e-8 Tonometry; LUSC cis rs1018836 0.632 rs7002775 chr8:91476765 C/T cg16814680 chr8:91681699 NA 0.65 9.63 0.47 1.61e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg24692254 chr21:30365293 RNF160 -0.7 -10.73 -0.51 2.81e-23 Pancreatic cancer; LUSC cis rs701145 0.556 rs355751 chr3:153971602 T/C cg10247383 chr3:153839028 SGEF -0.49 -5.98 -0.31 5.67e-9 Coronary artery disease; LUSC cis rs7089973 0.604 rs7920216 chr10:116611794 G/A cg03647239 chr10:116582469 FAM160B1 0.44 7.06 0.36 9.98e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10465746 0.780 rs2389648 chr1:84403031 C/T cg10977910 chr1:84465055 TTLL7 0.43 6.18 0.32 1.88e-9 Obesity-related traits; LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.2 -0.37 4.03e-12 Bipolar disorder; LUSC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg11062466 chr8:58055876 NA -0.49 -6.68 -0.34 1.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg16606324 chr3:10149918 C3orf24 0.65 9.7 0.47 9.37e-20 Alzheimer's disease; LUSC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg11663144 chr21:46675770 NA -0.36 -5.98 -0.31 5.68e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg22906224 chr7:99728672 NA 0.55 8.13 0.41 8.36e-15 Coronary artery disease; LUSC cis rs7705502 1.000 rs72812818 chr5:173356752 G/C cg18693985 chr5:173351052 CPEB4 -0.38 -6.02 -0.31 4.66e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs734999 1.000 rs10797432 chr1:2501338 C/T cg18854424 chr1:2615690 NA 0.45 9.56 0.46 2.65e-19 Ulcerative colitis; LUSC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg23711669 chr6:146136114 FBXO30 -0.79 -13.87 -0.6 7.6e-35 Lobe attachment (rater-scored or self-reported); LUSC trans rs7939886 0.920 rs4489763 chr11:55944474 G/A cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC cis rs9326248 0.581 rs4938331 chr11:116930682 C/A cg11861562 chr11:117069780 TAGLN 0.33 6.38 0.33 5.8e-10 Blood protein levels; LUSC cis rs6138458 0.828 rs6132785 chr20:24993414 T/C cg26195577 chr20:24973756 C20orf3 0.81 12.44 0.56 1.84e-29 Blood protein levels; LUSC trans rs7824557 0.628 rs6988922 chr8:11194911 A/G cg15556689 chr8:8085844 FLJ10661 0.47 7.1 0.36 7.71e-12 Retinal vascular caliber; LUSC cis rs9341808 0.500 rs2322629 chr6:80811540 C/T cg08355045 chr6:80787529 NA 0.55 9.9 0.48 2.05e-20 Sitting height ratio; LUSC cis rs9311676 0.618 rs12152337 chr3:58365271 T/C cg26110898 chr3:58419937 PDHB 0.44 7.22 0.37 3.62e-12 Systemic lupus erythematosus; LUSC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2835872 0.758 rs1709818 chr21:39036211 T/C cg20424643 chr21:39039972 KCNJ6 -0.44 -7.42 -0.38 9.81e-13 Electroencephalographic traits in alcoholism; LUSC cis rs4363385 0.818 rs2879487 chr1:152985360 C/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.67 -0.3 3.09e-8 Inflammatory skin disease; LUSC cis rs6570726 0.902 rs9390326 chr6:145791222 A/G cg23711669 chr6:146136114 FBXO30 -0.7 -12.09 -0.55 3.72e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs7177699 0.557 rs4389112 chr15:79122099 G/A cg00540400 chr15:79124168 NA -0.47 -8.1 -0.41 1.02e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11039100 0.607 rs1032647 chr11:5781889 A/G cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg26318627 chr11:63887540 MACROD1 0.34 6.49 0.33 3.02e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs9309473 0.514 rs62149659 chr2:73585196 C/T cg20560298 chr2:73613845 ALMS1 -0.51 -5.98 -0.31 5.79e-9 Metabolite levels; LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg19346786 chr7:2764209 NA -0.51 -8.62 -0.43 2.67e-16 Height; LUSC cis rs17095355 0.786 rs61624875 chr10:111722489 T/C cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.44 -0.38 8.8e-13 Biliary atresia; LUSC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg26335602 chr6:28129616 ZNF389 0.43 5.74 0.3 2.17e-8 Depression; LUSC cis rs9660992 0.512 rs12142402 chr1:205128215 A/T cg21643547 chr1:205240462 TMCC2 -0.41 -7.55 -0.38 4.13e-13 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4308124 0.708 rs67816163 chr2:111963310 A/G cg04571233 chr2:111982156 NA -0.5 -6.55 -0.34 2.11e-10 Vitiligo; LUSC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11890956 chr21:40555474 PSMG1 -0.88 -14.18 -0.61 4.78e-36 Cognitive function; LUSC trans rs7819412 0.645 rs10156356 chr8:11046209 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.25 -0.37 2.89e-12 Triglycerides; LUSC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg05082376 chr22:42548792 NA -0.4 -5.98 -0.31 5.75e-9 Schizophrenia; LUSC trans rs6502050 0.835 rs9904520 chr17:80100117 T/C cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs8103278 0.507 rs10401971 chr19:46261982 C/T cg14061069 chr19:46274453 DMPK 0.68 14.05 0.61 1.51e-35 Coronary artery disease; LUSC cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.54 -8.45 -0.42 9.27e-16 Prudent dietary pattern; LUSC cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg19920283 chr7:105172520 RINT1 0.62 6.9 0.35 2.59e-11 Bipolar disorder (body mass index interaction); LUSC cis rs11098499 0.954 rs11098526 chr4:120390359 C/T cg24375607 chr4:120327624 NA 0.79 11.6 0.54 2.32e-26 Corneal astigmatism; LUSC cis rs1775715 0.737 rs2808028 chr10:32101189 G/A cg26784012 chr10:32216390 ARHGAP12 0.44 7.39 0.37 1.21e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs66887589 0.748 rs28439855 chr4:120262256 G/A cg24375607 chr4:120327624 NA 0.49 7.62 0.38 2.61e-13 Diastolic blood pressure; LUSC cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg14416269 chr4:6271139 WFS1 0.49 9.78 0.47 4.89e-20 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2979472 0.525 rs62505283 chr8:30459993 C/T cg26383811 chr8:30366931 RBPMS -0.42 -6.76 -0.35 6.23e-11 Lymphocyte percentage of white cells; LUSC cis rs2425143 1.000 rs11167275 chr20:34340275 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.29 -0.33 9.76e-10 Blood protein levels; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.27 5.75 0.3 2.01e-8 Electroencephalogram traits; LUSC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg13175981 chr1:150552382 MCL1 0.47 6.7 0.34 8.66e-11 Tonsillectomy; LUSC cis rs10072221 1.000 rs10077372 chr5:75720649 C/T cg03132911 chr5:75698732 IQGAP2 0.35 5.7 0.3 2.7e-8 Mean platelet volume; LUSC cis rs5756813 0.727 rs4820303 chr22:38134166 G/A cg06521852 chr22:38141419 TRIOBP 0.42 6.29 0.33 9.7e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs568617 0.768 rs12225345 chr11:65647105 A/G cg19792802 chr11:65647270 CTSW 0.44 6.43 0.33 4.48e-10 Crohn's disease; LUSC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg07716408 chr11:68623521 NA -0.3 -5.72 -0.3 2.35e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2486288 0.656 rs11637364 chr15:45579238 C/T cg26924012 chr15:45694286 SPATA5L1 -0.75 -10.95 -0.51 4.92e-24 Glomerular filtration rate; LUSC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg13607699 chr17:42295918 UBTF 0.55 8.64 0.43 2.39e-16 Total body bone mineral density; LUSC cis rs868036 0.958 rs12593813 chr15:68036852 C/T cg05925327 chr15:68127851 NA -0.33 -5.86 -0.31 1.13e-8 Restless legs syndrome; LUSC cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg17509989 chr5:176798049 RGS14 0.64 8.93 0.44 2.9e-17 Urate levels in lean individuals; LUSC cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg05868516 chr6:26286170 HIST1H4H 0.36 5.77 0.3 1.79e-8 Educational attainment; LUSC cis rs73206853 0.841 rs56122570 chr12:110816291 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg21724239 chr8:58056113 NA 0.78 8.17 0.41 6.56e-15 Developmental language disorder (linguistic errors); LUSC cis rs11190604 0.943 rs7085261 chr10:102209811 G/A cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg09044154 chr16:88155775 NA -0.56 -7.55 -0.38 4.16e-13 Menopause (age at onset); LUSC cis rs9527 0.545 rs10883847 chr10:104958284 C/T cg05855489 chr10:104503620 C10orf26 0.51 7.9 0.4 3.95e-14 Arsenic metabolism; LUSC cis rs9814567 0.727 rs9809344 chr3:134342758 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.86 -0.58 5.11e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg00166722 chr3:10149974 C3orf24 0.56 7.84 0.39 5.91e-14 Alzheimer's disease; LUSC cis rs9467773 0.620 rs2451744 chr6:26633463 G/T cg05738196 chr6:26577821 NA 0.78 14.95 0.63 4.82e-39 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg26314531 chr2:26401878 FAM59B -0.69 -9.3 -0.45 1.91e-18 Gut microbiome composition (summer); LUSC cis rs75920871 0.528 rs2513094 chr11:116806412 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.49 -6.11 -0.32 2.75e-9 Subjective well-being; LUSC cis rs96067 0.805 rs1033890 chr1:36608414 C/T cg24686825 chr1:36642396 MAP7D1 -0.72 -9.68 -0.47 1.11e-19 Corneal structure; LUSC cis rs6138458 1.000 rs227627 chr20:24912107 T/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.94 -0.36 1.99e-11 Blood protein levels; LUSC trans rs2832077 0.943 rs2832100 chr21:30175628 A/C cg14791747 chr16:20752902 THUMPD1 0.68 9.38 0.46 1.02e-18 Cognitive test performance; LUSC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg00509249 chr6:109615579 CCDC162 -0.33 -5.9 -0.31 9.06e-9 Reticulocyte fraction of red cells; LUSC cis rs67311347 0.713 rs73073505 chr3:40310693 C/T cg17264618 chr3:40429014 ENTPD3 0.3 6.3 0.33 9.12e-10 Renal cell carcinoma; LUSC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg09455208 chr3:40491958 NA 0.62 9.43 0.46 7.15e-19 Renal cell carcinoma; LUSC cis rs76878669 0.917 rs10219183 chr11:66090032 A/C cg18002602 chr11:66138449 SLC29A2 0.39 6.04 0.31 4e-9 Educational attainment (years of education); LUSC cis rs2074585 0.560 rs12903058 chr15:91061121 G/T cg22089800 chr15:90895588 ZNF774 -0.59 -8.47 -0.42 8.16e-16 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs6561151 0.645 rs61959960 chr13:44439265 T/G cg12856521 chr11:46389249 DGKZ 0.79 9.72 0.47 8.13e-20 Crohn's disease; LUSC cis rs831571 0.519 rs13059603 chr3:63827381 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.56 7.39 0.37 1.22e-12 Type 2 diabetes; LUSC cis rs11105298 0.786 rs3803128 chr12:89860319 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.22 -0.37 3.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4363385 0.818 rs3820141 chr1:153004778 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.42e-12 Inflammatory skin disease; LUSC cis rs11190604 1.000 rs2298074 chr10:102247526 G/C cg07080220 chr10:102295463 HIF1AN 0.66 8.5 0.42 6.62e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7107174 1.000 rs11602622 chr11:78010830 A/G cg02023728 chr11:77925099 USP35 0.47 6.82 0.35 4.36e-11 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs9359856 0.550 rs1179905 chr6:90322922 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.38 -0.46 1.03e-18 Bipolar disorder; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg02353165 chr6:42928485 GNMT 0.66 11.36 0.53 1.61e-25 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg13944838 chr5:179740914 GFPT2 -0.59 -9.2 -0.45 4.07e-18 Height; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg16031515 chr1:205743344 RAB7L1 -0.3 -6.36 -0.33 6.52e-10 Menarche (age at onset); LUSC trans rs208520 0.690 rs207081 chr6:66773742 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -16.65 -0.67 9.68e-46 Exhaled nitric oxide output; LUSC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg03948781 chr1:205179583 DSTYK 0.3 5.65 0.3 3.5e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs62103177 0.608 rs613847 chr18:77845644 A/G cg20368463 chr18:77673604 PQLC1 -0.63 -6.72 -0.34 8.05e-11 Opioid sensitivity; LUSC cis rs12286929 0.679 rs11606814 chr11:115042513 G/T cg04055981 chr11:115044050 NA 0.44 7.98 0.4 2.44e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg24796726 chr7:884288 UNC84A -0.36 -5.77 -0.3 1.79e-8 Perceived unattractiveness to mosquitoes; LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg08470875 chr2:26401718 FAM59B -0.69 -9.37 -0.46 1.16e-18 Gut microbiome composition (summer); LUSC cis rs9549367 0.789 rs2302754 chr13:113898385 C/T cg18105134 chr13:113819100 PROZ 0.66 9.51 0.46 3.94e-19 Platelet distribution width; LUSC cis rs9902453 0.934 rs4427857 chr17:28457989 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.13 0.45 6.89e-18 Coffee consumption (cups per day); LUSC trans rs7939886 0.920 rs7112815 chr11:55960104 T/C cg15704280 chr7:45808275 SEPT13 0.89 6.88 0.35 3e-11 Myopia (pathological); LUSC cis rs11031096 0.801 rs1372805 chr11:4085529 A/C cg18678763 chr11:4115507 RRM1 0.4 5.89 0.31 9.31e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg15369054 chr17:80825471 TBCD 0.7 11.66 0.54 1.38e-26 Breast cancer; LUSC cis rs713587 0.967 rs6749422 chr2:25150011 C/G cg01884057 chr2:25150051 NA 0.48 11.43 0.53 9.6e-26 Body mass index in non-asthmatics; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14307892 chr10:124767941 IKZF5;ACADSB 0.41 6.24 0.32 1.31e-9 Mosquito bite size; LUSC cis rs3768617 0.811 rs10797828 chr1:183028430 G/A ch.1.3577855R chr1:183094577 LAMC1 0.61 8.78 0.43 8.41e-17 Fuchs's corneal dystrophy; LUSC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg20406979 chr6:167373233 NA -0.26 -6.08 -0.32 3.35e-9 Crohn's disease; LUSC cis rs6696846 0.765 rs4394715 chr1:205108393 T/G cg21545522 chr1:205238299 TMCC2 0.46 8.71 0.43 1.39e-16 Red blood cell count; LUSC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg19052272 chr2:3704530 ALLC -0.5 -8.38 -0.42 1.48e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs2797160 0.837 rs1739364 chr6:126022383 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.62 -0.38 2.7e-13 Endometrial cancer; LUSC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC trans rs61931739 0.817 rs10772143 chr12:34230651 T/G cg26384229 chr12:38710491 ALG10B 0.53 8.49 0.42 7.1e-16 Morning vs. evening chronotype; LUSC cis rs2463822 0.669 rs72919493 chr11:62049651 C/A cg06239285 chr11:62104954 ASRGL1 -0.73 -6.88 -0.35 2.9100000000000002e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7084921 0.608 rs12761969 chr10:101832036 G/C cg11888571 chr10:102027403 CWF19L1 -0.41 -5.68 -0.3 2.95e-8 Bone mineral density; LUSC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg05623727 chr3:50126028 RBM5 -0.32 -6.09 -0.32 3.11e-9 Body mass index; LUSC trans rs7819412 1.000 rs2409722 chr8:11039816 T/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.11 -0.41 9.51e-15 Triglycerides; LUSC cis rs6598955 0.670 rs11247892 chr1:26592727 A/G cg00852783 chr1:26633632 UBXN11 0.49 8.61 0.43 2.9e-16 Obesity-related traits; LUSC cis rs6984449 0.508 rs62496184 chr8:19319423 G/A cg06562184 chr8:19319451 CSGALNACT1 0.5 8.2 0.41 5.3e-15 Educational attainment; LUSC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg05425664 chr17:57184151 TRIM37 -0.57 -8.37 -0.42 1.59e-15 Intelligence (multi-trait analysis); LUSC cis rs12618769 1.000 rs3769694 chr2:99259239 C/G cg10123293 chr2:99228465 UNC50 0.43 5.96 0.31 6.29e-9 Bipolar disorder; LUSC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg20744362 chr22:50050164 C22orf34 0.35 7.09 0.36 8.17e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg25427524 chr10:38739819 LOC399744 -0.58 -10.26 -0.49 1.17e-21 Extrinsic epigenetic age acceleration; LUSC cis rs950027 0.620 rs1145093 chr15:45649813 C/A cg26924012 chr15:45694286 SPATA5L1 0.79 12.5 0.56 1.13e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs734999 0.588 rs3748818 chr1:2525660 G/A cg18932078 chr1:2524107 MMEL1 0.33 7.17 0.37 4.87e-12 Ulcerative colitis; LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg10729496 chr3:10149963 C3orf24 0.52 6.93 0.35 2.21e-11 Alzheimer's disease; LUSC cis rs9534288 0.912 rs2404732 chr13:46618611 C/A cg15192986 chr13:46630673 CPB2 -0.74 -11.4 -0.53 1.18e-25 Blood protein levels; LUSC cis rs7582180 0.544 rs13026570 chr2:100939498 A/C cg08017756 chr2:100939284 LONRF2 -0.44 -8.15 -0.41 7.43e-15 Intelligence (multi-trait analysis); LUSC cis rs243505 0.964 rs243509 chr7:148433634 G/A cg09806900 chr7:148480153 CUL1 -0.5 -7.11 -0.36 7.09e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9300255 0.596 rs7304782 chr12:123719444 A/G cg00376283 chr12:123451042 ABCB9 -0.69 -9.92 -0.48 1.64e-20 Neutrophil percentage of white cells; LUSC trans rs634534 0.622 rs552130 chr11:65732800 T/C cg17712092 chr4:129076599 LARP1B 0.75 11.4 0.53 1.16e-25 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs6964587 0.900 rs6465352 chr7:91775117 A/G cg17063962 chr7:91808500 NA 0.6 9.65 0.47 1.34e-19 Breast cancer; LUSC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg04025307 chr7:1156635 C7orf50 0.42 5.89 0.31 9.25e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs5758511 0.689 rs17002947 chr22:42688532 C/T cg12850546 chr22:42539477 CYP2D7P1 0.51 6.09 0.32 3.05e-9 Birth weight; LUSC cis rs1865760 1.000 rs3799371 chr6:25912816 A/G cg16482183 chr6:26056742 HIST1H1C -0.45 -6.75 -0.35 6.62e-11 Height; LUSC cis rs7968679 1 rs7968679 chr12:9313304 A/G cg20380214 chr12:9217688 LOC144571 -0.41 -7.99 -0.4 2.19e-14 Myopia; LUSC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg03477792 chr4:77819574 ANKRD56 0.49 6.8 0.35 4.93e-11 Emphysema distribution in smoking; LUSC cis rs7607369 0.648 rs17470271 chr2:219651995 A/T cg02176678 chr2:219576539 TTLL4 0.66 13.18 0.59 3.06e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs2625529 0.652 rs2899776 chr15:72268365 A/T cg16672083 chr15:72433130 SENP8 0.48 7.92 0.4 3.52e-14 Red blood cell count; LUSC cis rs1577917 0.916 rs12206726 chr6:86499716 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.86 -0.44 4.78e-17 Response to antipsychotic treatment; LUSC cis rs2708977 0.637 rs675239 chr2:97076556 A/G cg01950434 chr2:97203154 ARID5A -0.44 -6.28 -0.33 1.04e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.47 6.17 0.32 1.95e-9 Tonsillectomy; LUSC cis rs7084921 0.608 rs1853700 chr10:101862694 T/C cg02250046 chr10:101825185 CPN1 -0.34 -6.19 -0.32 1.75e-9 Bone mineral density; LUSC cis rs727505 1.000 rs10233596 chr7:124556659 A/G cg23710748 chr7:124431027 NA -0.41 -7.39 -0.37 1.18e-12 Lewy body disease; LUSC cis rs9527 0.590 rs7087040 chr10:104799668 G/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.63 -0.34 1.33e-10 Arsenic metabolism; LUSC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg18131467 chr2:239335373 ASB1 -0.7 -9.46 -0.46 5.67e-19 Multiple system atrophy; LUSC cis rs9638182 0.582 rs12539351 chr7:72978112 A/G cg07452164 chr7:72993570 TBL2 0.44 6.3 0.33 9.24e-10 Triglycerides; LUSC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg03929089 chr4:120376271 NA -0.95 -16.34 -0.67 1.59e-44 Height; LUSC cis rs7903847 0.619 rs9888116 chr10:99159482 G/A cg08345082 chr10:99160200 RRP12 -0.35 -7.11 -0.36 7.29e-12 Granulocyte percentage of myeloid white cells; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg05062854 chr22:32435553 NA 0.44 6.88 0.35 2.95e-11 Calcium levels; LUSC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg01065977 chr19:18549689 ISYNA1 -0.23 -5.74 -0.3 2.14e-8 Breast cancer; LUSC cis rs2635047 0.967 rs2576030 chr18:44659166 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 7.77 0.39 9.83e-14 Educational attainment; LUSC cis rs9905704 0.846 rs302863 chr17:56698827 A/G cg12560992 chr17:57184187 TRIM37 -0.56 -8.02 -0.4 1.79e-14 Testicular germ cell tumor; LUSC trans rs2018683 0.707 rs4722878 chr7:28973031 C/T cg19402173 chr7:128379420 CALU -0.47 -7.08 -0.36 8.32e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs12681288 0.523 rs111782857 chr8:962486 T/C cg15309053 chr8:964076 NA 0.4 7.97 0.4 2.55e-14 Schizophrenia; LUSC cis rs7264396 0.943 rs224421 chr20:34145461 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.81 -0.35 4.57e-11 Total cholesterol levels; LUSC cis rs7582720 1.000 rs79642273 chr2:203830851 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg11247378 chr22:39784982 NA -0.45 -6.97 -0.36 1.72e-11 IgG glycosylation; LUSC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.66 -0.3 3.23e-8 Life satisfaction; LUSC cis rs8028313 0.630 rs16951105 chr15:67965694 A/G cg05925327 chr15:68127851 NA -0.43 -6.5 -0.34 2.91e-10 Obesity; LUSC cis rs1008375 1.000 rs9991307 chr4:17662408 A/G cg16339924 chr4:17578868 LAP3 0.54 8.0 0.4 2.06e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg03146154 chr1:46216737 IPP -0.5 -7.22 -0.37 3.63e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22633769 chr20:60982531 CABLES2 -0.46 -6.01 -0.31 4.78e-9 Colorectal cancer; LUSC cis rs9581857 0.725 rs1924074 chr13:28015387 C/G cg22138327 chr13:27999177 GTF3A -0.87 -9.31 -0.45 1.72e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs599083 0.530 rs667126 chr11:68177728 C/T cg01657329 chr11:68192670 LRP5 0.48 6.34 0.33 7.28e-10 Bone mineral density (spine); LUSC cis rs6546550 0.901 rs897120 chr2:70160982 C/T cg02498382 chr2:70120550 SNRNP27 0.3 7.39 0.37 1.17e-12 Prevalent atrial fibrillation; LUSC cis rs1559088 0.948 rs3760893 chr19:33597930 C/A cg17764715 chr19:33622953 WDR88 0.6 8.29 0.41 2.72e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13849007 chr1:1677539 SLC35E2 -0.43 -6.17 -0.32 2.02e-9 Electrocardiographic conduction measures; LUSC cis rs3857536 0.813 rs6903678 chr6:66931208 C/T cg07460842 chr6:66804631 NA 0.41 5.88 0.31 9.77e-9 Blood trace element (Cu levels); LUSC cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg19717773 chr7:2847554 GNA12 -0.4 -7.14 -0.36 5.98e-12 Height; LUSC trans rs9291683 0.668 rs2241474 chr4:10086015 T/C cg26043149 chr18:55253948 FECH 0.49 7.5 0.38 5.95e-13 Bone mineral density; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg23223044 chr19:49990882 RPL13AP5;RPL13A 0.5 5.98 0.31 5.83e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs735539 0.645 rs1329518 chr13:21203611 C/G cg04906043 chr13:21280425 IL17D -0.43 -6.71 -0.34 8.15e-11 Dental caries; LUSC cis rs921968 0.643 rs579610 chr2:219327582 C/A cg02176678 chr2:219576539 TTLL4 0.64 11.63 0.54 1.77e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg24531977 chr5:56204891 C5orf35 -0.71 -10.9 -0.51 7.37e-24 Coronary artery disease; LUSC cis rs858239 0.601 rs6969733 chr7:23168377 T/C cg23682824 chr7:23144976 KLHL7 0.41 5.86 0.31 1.13e-8 Cerebrospinal fluid biomarker levels; LUSC trans rs11992162 0.551 rs35010200 chr8:11785655 G/A cg06636001 chr8:8085503 FLJ10661 -0.45 -6.31 -0.33 8.93e-10 Monocyte count; LUSC cis rs72781680 0.898 rs56179550 chr2:23934867 C/T cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.48e-12 Lymphocyte counts; LUSC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg26162295 chr17:38119207 GSDMA -0.29 -6.96 -0.36 1.8e-11 Asthma; LUSC trans rs2797160 1.000 rs6933302 chr6:126016951 T/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.85 0.35 3.56e-11 Endometrial cancer; LUSC cis rs9467773 1.000 rs6903973 chr6:26499942 C/A cg09904177 chr6:26538194 HMGN4 0.72 13.02 0.58 1.28e-31 Intelligence (multi-trait analysis); LUSC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg22834771 chr12:69754056 YEATS4 -0.56 -8.33 -0.41 2.1e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs667920 0.575 rs9861150 chr3:136183320 G/T cg15507776 chr3:136538369 TMEM22 0.51 6.52 0.34 2.63e-10 Coronary artery disease; LUSC cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.12 15.52 0.65 2.89e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7575217 0.961 rs13397388 chr2:101779648 C/T cg23907051 chr2:101730305 TBC1D8 -0.26 -6.69 -0.34 9.44e-11 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.39 8.29 0.41 2.76e-15 Hemoglobin concentration; LUSC cis rs1358748 0.555 rs2093335 chr1:67537091 C/T cg02640540 chr1:67518911 SLC35D1 0.62 6.52 0.34 2.6e-10 Tuberculosis; LUSC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg21951975 chr1:209979733 IRF6 0.56 7.03 0.36 1.2e-11 Cleft lip with or without cleft palate; LUSC cis rs7827545 1.000 rs6578234 chr8:135566363 A/G cg17885191 chr8:135476712 NA 0.53 7.76 0.39 1.04e-13 Hypertension (SNP x SNP interaction); LUSC cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -6.44 -0.33 4.17e-10 Schizophrenia; LUSC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg24675658 chr1:53192096 ZYG11B 0.62 10.05 0.48 5.99e-21 Monocyte count; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg00024416 chr22:24240387 NA 0.33 5.86 0.31 1.13e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs72674100 1.000 rs10002900 chr4:97974161 T/A cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.6 0.34 1.66e-10 Lung cancer; LUSC cis rs9341808 0.754 rs9341810 chr6:80974838 G/A cg08355045 chr6:80787529 NA 0.56 9.76 0.47 5.61e-20 Sitting height ratio; LUSC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg03806693 chr22:41940476 POLR3H -0.97 -14.11 -0.61 8.63e-36 Vitiligo; LUSC trans rs7824557 0.736 rs35392635 chr8:11164349 G/C cg15556689 chr8:8085844 FLJ10661 0.56 8.58 0.42 3.52e-16 Retinal vascular caliber; LUSC cis rs4343996 0.902 rs4722693 chr7:3374312 C/T cg21248987 chr7:3385318 SDK1 -0.38 -6.42 -0.33 4.75e-10 Motion sickness; LUSC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg03929089 chr4:120376271 NA -1.04 -20.46 -0.75 7.01e-61 Height; LUSC cis rs11098499 0.863 rs3822191 chr4:120428101 A/T cg24375607 chr4:120327624 NA 0.75 11.04 0.52 2.38e-24 Corneal astigmatism; LUSC cis rs701145 0.585 rs1632688 chr3:153874139 C/A cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg23262073 chr20:60523788 NA 0.59 8.5 0.42 6.33e-16 Obesity-related traits; LUSC cis rs921943 0.957 rs6860801 chr5:78310914 C/G cg16405876 chr5:78317871 DMGDH 0.28 5.69 0.3 2.84e-8 Blood and toenail selenium levels;Blood trace element (Se levels); LUSC cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg21643547 chr1:205240462 TMCC2 -0.53 -10.19 -0.49 2.1e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12701220 0.894 rs10263252 chr7:1049949 G/A cg06145435 chr7:1022769 CYP2W1 0.34 5.89 0.31 9.54e-9 Bronchopulmonary dysplasia; LUSC cis rs11650494 0.831 rs11650886 chr17:47449193 G/A cg08112188 chr17:47440006 ZNF652 1.4 11.55 0.53 3.57e-26 Prostate cancer; LUSC cis rs7614311 0.681 rs73117036 chr3:63892725 G/C cg22134162 chr3:63841271 THOC7 -0.49 -6.15 -0.32 2.17e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs78366141 0.649 rs77135481 chr4:89689680 T/C cg01026744 chr4:89619053 NAP1L5;HERC3 0.93 6.8 0.35 4.73e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs72960926 0.744 rs56168817 chr6:75043919 A/G cg03266952 chr6:74778945 NA -0.77 -6.63 -0.34 1.34e-10 Metabolite levels (MHPG); LUSC cis rs75229567 0.618 rs1882194 chr12:70215086 C/G cg10114359 chr12:70132523 RAB3IP -0.93 -8.92 -0.44 3.24e-17 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04155289 chr7:94953770 PON1 -0.54 -11.39 -0.53 1.35e-25 Paraoxonase activity; LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg23978390 chr7:1156363 C7orf50 0.41 5.98 0.31 5.7e-9 Longevity;Endometriosis; LUSC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.57 0.38 3.58e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs9399135 0.967 rs7750300 chr6:135350950 C/G cg24558204 chr6:135376177 HBS1L 0.61 9.59 0.46 2.15e-19 Red blood cell count; LUSC cis rs9494145 0.531 rs9399136 chr6:135402339 T/C cg22676075 chr6:135203613 NA 0.67 9.44 0.46 6.57e-19 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs9467711 0.591 rs13214280 chr6:26008620 C/T cg16898833 chr6:26189333 HIST1H4D 0.67 6.51 0.34 2.72e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg04369109 chr6:150039330 LATS1 -0.51 -7.24 -0.37 3.11e-12 Lung cancer; LUSC cis rs453301 0.598 rs10104303 chr8:8834528 A/T cg15556689 chr8:8085844 FLJ10661 0.64 10.29 0.49 9.4e-22 Joint mobility (Beighton score); LUSC cis rs9457247 0.508 rs7760495 chr6:167506795 C/T cg07741184 chr6:167504864 NA 0.4 6.88 0.35 2.93e-11 Crohn's disease; LUSC cis rs4919694 0.572 rs12262258 chr10:104900272 G/A cg04362960 chr10:104952993 NT5C2 0.9 11.69 0.54 1.06e-26 Arsenic metabolism; LUSC trans rs6561151 0.681 rs2325088 chr13:44424063 T/C cg12856521 chr11:46389249 DGKZ 0.75 9.56 0.46 2.63e-19 Crohn's disease; LUSC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.76 12.54 0.57 7.84e-30 Menarche (age at onset); LUSC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg22496339 chr2:162101262 NA 0.73 11.88 0.54 2.26e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg25427524 chr10:38739819 LOC399744 -0.62 -11.09 -0.52 1.56e-24 Extrinsic epigenetic age acceleration; LUSC cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg11266682 chr4:10021025 SLC2A9 0.5 9.39 0.46 9.86e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg18681998 chr4:17616180 MED28 0.79 13.28 0.59 1.26e-32 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg12311346 chr5:56204834 C5orf35 -0.9 -13.07 -0.58 8.49e-32 Initial pursuit acceleration; LUSC cis rs4499344 0.730 rs12460624 chr19:33098042 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.64 0.57 3.31e-30 Mean platelet volume; LUSC cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs977987 0.806 rs2903033 chr16:75389606 T/A cg03315344 chr16:75512273 CHST6 0.51 9.66 0.47 1.2e-19 Dupuytren's disease; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg04025307 chr7:1156635 C7orf50 0.56 8.81 0.43 7.18e-17 Longevity;Endometriosis; LUSC cis rs10750766 1 rs10750766 chr11:65473798 C/A cg08755490 chr11:65554678 OVOL1 0.56 7.71 0.39 1.46e-13 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs12971120 0.891 rs12605820 chr18:72167802 G/A cg25817165 chr18:72167213 CNDP2 -0.75 -9.1 -0.45 8.37e-18 Refractive error; LUSC cis rs7264396 0.528 rs3787174 chr20:34487921 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.42 -0.33 4.63e-10 Total cholesterol levels; LUSC cis rs1018836 0.637 rs7843684 chr8:91470035 G/C cg16814680 chr8:91681699 NA -0.53 -7.75 -0.39 1.13e-13 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg17366294 chr4:99064904 C4orf37 0.54 9.48 0.46 4.75e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg03806693 chr22:41940476 POLR3H 0.95 12.89 0.58 3.76e-31 Vitiligo; LUSC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg17330251 chr7:94953956 PON1 -0.37 -5.87 -0.31 1.06e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs11971779 0.680 rs11765421 chr7:139025094 G/A cg07862535 chr7:139043722 LUC7L2 0.54 6.72 0.35 7.8e-11 Diisocyanate-induced asthma; LUSC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg11247378 chr22:39784982 NA -0.65 -11.98 -0.55 9.67e-28 Intelligence (multi-trait analysis); LUSC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg16060761 chr17:80687452 NA 0.51 7.99 0.4 2.18e-14 Glycated hemoglobin levels; LUSC cis rs11039100 0.850 rs11039118 chr11:5832601 A/G cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg15147215 chr3:52552868 STAB1 -0.31 -6.34 -0.33 7.65e-10 Bipolar disorder; LUSC cis rs11039100 1.000 rs4319539 chr11:5828846 T/A cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg08888203 chr3:10149979 C3orf24 0.59 8.11 0.41 9.88e-15 Alzheimer's disease; LUSC cis rs6665290 0.669 rs3768424 chr1:227177444 A/G cg10327440 chr1:227177885 CDC42BPA -1.11 -28.96 -0.85 4.25e-93 Myeloid white cell count; LUSC cis rs34779708 0.733 rs3853672 chr10:35549606 A/C cg03585969 chr10:35415529 CREM 0.54 7.41 0.38 1.05e-12 Inflammatory bowel disease;Crohn's disease; LUSC trans rs61931739 0.500 rs12367292 chr12:33998075 T/C cg26384229 chr12:38710491 ALG10B 0.74 11.5 0.53 5.04e-26 Morning vs. evening chronotype; LUSC cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg01028140 chr2:1542097 TPO -0.61 -8.33 -0.41 2.15e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs757081 0.636 rs214934 chr11:17193475 T/A cg15432903 chr11:17409602 KCNJ11 -0.39 -5.98 -0.31 5.7e-9 Systolic blood pressure; LUSC cis rs4700695 0.719 rs27587 chr5:65444163 C/T cg21114390 chr5:65439923 SFRS12 -0.62 -8.74 -0.43 1.18e-16 Facial morphology (factor 19); LUSC cis rs939658 0.805 rs11630571 chr15:79432992 C/A cg17916960 chr15:79447300 NA -0.52 -10.41 -0.49 3.78e-22 Refractive error; LUSC cis rs7582180 0.627 rs6542947 chr2:100999647 C/G cg12002119 chr2:101014098 CHST10 -0.4 -6.76 -0.35 5.98e-11 Intelligence (multi-trait analysis); LUSC cis rs7953249 0.618 rs2650000 chr12:121388962 G/T cg25281562 chr12:121454272 C12orf43 0.42 5.69 0.3 2.76e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs3806843 0.966 rs2563263 chr5:140137644 A/G cg26395211 chr5:140044315 WDR55 -0.4 -5.66 -0.3 3.27e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg07828024 chr6:149772892 ZC3H12D 0.33 7.21 0.37 3.7e-12 Dupuytren's disease; LUSC cis rs12586317 0.620 rs28870452 chr14:35536878 C/A cg05294307 chr14:35346193 BAZ1A -0.57 -6.87 -0.35 3.07e-11 Psoriasis; LUSC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -8.61 -0.43 2.95e-16 Bipolar disorder and schizophrenia; LUSC trans rs61931739 0.500 rs11053248 chr12:34518011 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.25e-22 Morning vs. evening chronotype; LUSC cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg03146154 chr1:46216737 IPP 0.5 7.28 0.37 2.47e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg23649088 chr2:200775458 C2orf69 -0.77 -14.19 -0.61 4.48e-36 Osteoporosis; LUSC cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg22875332 chr1:76189707 ACADM -0.42 -6.31 -0.33 8.94e-10 Daytime sleep phenotypes; LUSC cis rs9326248 0.509 rs533556 chr11:116741572 A/C cg11861562 chr11:117069780 TAGLN 0.33 6.44 0.33 4.22e-10 Blood protein levels; LUSC cis rs9611519 0.964 rs2092563 chr22:41592677 G/A cg13813247 chr22:41461852 NA -0.36 -6.54 -0.34 2.25e-10 Neuroticism; LUSC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18099408 chr3:52552593 STAB1 -0.41 -7.21 -0.37 3.83e-12 Electroencephalogram traits; LUSC trans rs399593 0.848 rs449878 chr10:30897264 A/G cg23813156 chr20:47935243 NA -0.48 -5.95 -0.31 6.63e-9 Dental caries; LUSC cis rs9291683 0.588 rs35438220 chr4:9999398 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.6 0.5 8.12e-23 Bone mineral density; LUSC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg11062466 chr8:58055876 NA 0.5 6.57 0.34 1.89e-10 Developmental language disorder (linguistic errors); LUSC cis rs4285028 0.948 rs34837785 chr3:121657776 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.9 -0.48 1.91e-20 Multiple sclerosis; LUSC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg07636037 chr3:49044803 WDR6 1.03 18.02 0.7 3.34e-51 Parkinson's disease; LUSC cis rs7189233 0.955 rs72801821 chr16:53479652 G/A cg09728985 chr16:53543985 NA -0.33 -5.87 -0.31 1.08e-8 Intelligence (multi-trait analysis); LUSC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg19052272 chr2:3704530 ALLC -0.64 -10.77 -0.51 2.04e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.16e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs66887589 0.748 rs28439855 chr4:120262256 G/A cg09307838 chr4:120376055 NA 0.5 7.62 0.38 2.6e-13 Diastolic blood pressure; LUSC cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.9 -0.4 4.07e-14 Schizophrenia; LUSC cis rs6138458 1.000 rs7268095 chr20:24972333 C/T cg26195577 chr20:24973756 C20orf3 1.1 18.2 0.71 6.62e-52 Blood protein levels; LUSC cis rs7103648 0.545 rs6485795 chr11:47929846 G/A cg20307385 chr11:47447363 PSMC3 0.8 11.96 0.55 1.07e-27 Diastolic blood pressure;Systolic blood pressure; LUSC trans rs6011368 0.749 rs4809418 chr20:62915231 G/A cg13869341 chr1:15865 WASH5P -0.45 -6.97 -0.36 1.74e-11 Clozapine-induced cytotoxicity; LUSC cis rs3540 0.597 rs4620932 chr15:91036569 G/A cg10434728 chr15:90938212 IQGAP1 0.46 9.16 0.45 5.29e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs921665 0.831 rs7596478 chr2:3176358 A/G cg16434511 chr2:3151078 NA -0.61 -6.61 -0.34 1.55e-10 World class endurance athleticism; LUSC cis rs7940866 0.774 rs2162059 chr11:130831224 C/T cg12179176 chr11:130786555 SNX19 0.61 9.42 0.46 7.51e-19 Schizophrenia; LUSC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg06873352 chr17:61820015 STRADA 0.56 8.68 0.43 1.83e-16 Height; LUSC cis rs12893668 0.637 rs12892038 chr14:104068629 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -6.36 -0.33 6.47e-10 Reticulocyte count; LUSC trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg15704280 chr7:45808275 SEPT13 0.67 7.37 0.37 1.35e-12 Axial length; LUSC cis rs16854884 0.657 rs35085196 chr3:143712210 C/T cg06585982 chr3:143692056 C3orf58 0.48 7.53 0.38 4.94e-13 Economic and political preferences (feminism/equality); LUSC cis rs11958404 0.932 rs72816585 chr5:157433901 A/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs62481355 0.963 rs11768389 chr7:127150250 T/C cg25922125 chr7:127225783 GCC1 -0.43 -5.65 -0.3 3.48e-8 Type 2 diabetes; LUSC cis rs2502731 0.539 rs3003609 chr9:130984755 A/G cg09976142 chr9:130955436 CIZ1 -0.44 -7.4 -0.38 1.14e-12 Attention deficit hyperactivity disorder; LUSC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg17385448 chr1:15911702 AGMAT -0.33 -5.69 -0.3 2.75e-8 Systolic blood pressure; LUSC trans rs2797160 1.000 rs1739363 chr6:126020980 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.95 0.36 1.87e-11 Endometrial cancer; LUSC cis rs240764 0.578 rs11155613 chr6:101176642 T/C cg09795085 chr6:101329169 ASCC3 0.42 6.07 0.32 3.52e-9 Neuroticism; LUSC trans rs1005277 0.502 rs2800484 chr10:38542415 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.41 -0.46 8.46e-19 Extrinsic epigenetic age acceleration; LUSC cis rs12760731 0.720 rs10913535 chr1:178302914 C/A cg00404053 chr1:178313656 RASAL2 0.56 6.1 0.32 2.98e-9 Obesity-related traits; LUSC cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg17420585 chr12:42539391 GXYLT1 -0.39 -7.67 -0.39 1.93e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.96 -0.31 6.32e-9 Testicular germ cell tumor; LUSC cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.71 0.3 2.56e-8 Schizophrenia; LUSC cis rs12421382 0.659 rs11600110 chr11:109392438 A/G cg16359550 chr11:109292809 C11orf87 0.37 6.33 0.33 7.74e-10 Schizophrenia; LUSC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg13531842 chr10:38383804 ZNF37A -0.48 -7.41 -0.38 1.06e-12 Extrinsic epigenetic age acceleration; LUSC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg06740227 chr12:86229804 RASSF9 0.43 6.84 0.35 3.77e-11 Major depressive disorder; LUSC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.72 -0.39 1.35e-13 Chronic sinus infection; LUSC cis rs1267303 0.600 rs57100184 chr1:47004710 A/C cg25110126 chr1:46999211 NA 0.8 11.1 0.52 1.37e-24 Monobrow; LUSC cis rs9733 0.744 rs2089081 chr1:150800117 T/C cg04414720 chr1:150670196 GOLPH3L -0.43 -6.87 -0.35 3.22e-11 Tonsillectomy; LUSC cis rs7520050 0.801 rs6703960 chr1:46232723 C/T cg06784218 chr1:46089804 CCDC17 -0.31 -6.08 -0.32 3.36e-9 Red blood cell count;Reticulocyte count; LUSC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg05368731 chr17:41323189 NBR1 0.84 14.15 0.61 6.02e-36 Menopause (age at onset); LUSC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg22166914 chr1:53195759 ZYG11B 0.69 11.68 0.54 1.17e-26 Monocyte count; LUSC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg23625390 chr15:77176239 SCAPER 0.46 6.98 0.36 1.61e-11 Blood metabolite levels; LUSC cis rs13223928 0.631 rs12531881 chr7:3156842 C/T cg19214707 chr7:3157722 NA -0.57 -11.06 -0.52 2e-24 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs67460515 1.000 rs67460515 chr3:161068566 T/C cg03342759 chr3:160939853 NMD3 -0.49 -6.75 -0.35 6.63e-11 Parkinson's disease; LUSC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.81 -10.8 -0.51 1.64e-23 Schizophrenia; LUSC cis rs5756813 0.688 rs2413483 chr22:38127950 C/T cg06521852 chr22:38141419 TRIOBP 0.39 5.88 0.31 1.02e-8 Optic cup area;Vertical cup-disc ratio; LUSC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.82e-8 Depression; LUSC cis rs2708377 0.929 rs2597974 chr12:11252845 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs1215050 0.791 rs6813619 chr4:98830768 C/T cg05340658 chr4:99064831 C4orf37 -0.42 -6.7 -0.34 8.99e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8072100 0.688 rs8075843 chr17:45442363 C/T cg08085267 chr17:45401833 C17orf57 -0.51 -7.18 -0.37 4.58e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs745570 1.000 rs745570 chr17:77781725 A/G cg04986373 chr17:77768687 CBX8 0.39 7.76 0.39 1.04e-13 Breast cancer; LUSC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg04287289 chr16:89883240 FANCA -0.77 -13.22 -0.59 2.26e-32 Vitiligo; LUSC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg00074818 chr8:8560427 CLDN23 0.58 9.87 0.48 2.46e-20 Obesity-related traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00185336 chr7:73153699 ABHD11 0.45 6.82 0.35 4.31e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs61931739 0.534 rs1352207 chr12:34036862 C/T cg06521331 chr12:34319734 NA 0.47 7.89 0.4 4.41e-14 Morning vs. evening chronotype; LUSC cis rs6977660 0.619 rs71526305 chr7:19785374 G/C cg05791153 chr7:19748676 TWISTNB 0.67 6.98 0.36 1.63e-11 Thyroid stimulating hormone; LUSC trans rs7819412 0.715 rs2409727 chr8:11043236 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -7.92 -0.4 3.63e-14 Triglycerides; LUSC cis rs6750047 0.585 rs168054 chr2:38260282 C/G cg07380506 chr2:38303506 CYP1B1 -0.44 -6.2 -0.32 1.69e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg26897989 chr16:1907736 C16orf73 -0.43 -6.48 -0.33 3.33e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs1044826 0.553 rs295469 chr3:139212900 G/A cg15131784 chr3:139108705 COPB2 0.43 6.56 0.34 2.04e-10 Obesity-related traits; LUSC cis rs8072100 0.934 rs8067286 chr17:45594590 A/G cg25173405 chr17:45401733 C17orf57 0.37 5.85 0.3 1.19e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12986413 1.000 rs12459350 chr19:2176586 A/G cg09261902 chr19:2140048 AP3D1 0.32 5.96 0.31 6.42e-9 Height; LUSC cis rs1371867 0.846 rs2083499 chr8:101230534 T/A cg06002616 chr8:101225028 SPAG1 0.47 7.65 0.39 2.16e-13 Atrioventricular conduction; LUSC cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg02569458 chr12:86230093 RASSF9 0.53 8.56 0.42 4.18e-16 Major depressive disorder; LUSC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg20135002 chr11:47629003 NA -0.51 -8.13 -0.41 8.39e-15 Subjective well-being; LUSC cis rs8114671 0.539 rs2064453 chr20:33460810 T/C cg07148914 chr20:33460835 GGT7 0.58 8.64 0.43 2.3e-16 Height; LUSC cis rs11992162 0.621 rs13268810 chr8:11797430 A/T cg21775007 chr8:11205619 TDH 0.44 5.96 0.31 6.26e-9 Monocyte count; LUSC cis rs7584330 0.955 rs13432426 chr2:238388631 T/G cg14458575 chr2:238380390 NA 0.67 11.51 0.53 4.67e-26 Prostate cancer; LUSC cis rs11166629 0.502 rs2467028 chr8:135663313 A/G cg27224718 chr8:135614730 ZFAT -0.48 -7.01 -0.36 1.35e-11 Smoking quantity; LUSC cis rs4595586 0.545 rs7952765 chr12:39375325 C/G cg13010199 chr12:38710504 ALG10B 0.4 5.81 0.3 1.45e-8 Morning vs. evening chronotype; LUSC cis rs11583043 1.000 rs11584222 chr1:101480110 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 6.07 0.32 3.52e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg21856205 chr7:94953877 PON1 -0.37 -5.94 -0.31 7.07e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg08754478 chr10:133766260 PPP2R2D -0.62 -8.07 -0.4 1.29e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs4363385 0.818 rs11205175 chr1:153001296 A/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.4 -0.38 1.13e-12 Inflammatory skin disease; LUSC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg17330251 chr7:94953956 PON1 -0.37 -5.99 -0.31 5.35e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs5758511 0.773 rs1894714 chr22:42349134 T/G cg12850546 chr22:42539477 CYP2D7P1 0.47 5.82 0.3 1.36e-8 Birth weight; LUSC cis rs3768617 0.811 rs12138049 chr1:182979546 C/T ch.1.3577855R chr1:183094577 LAMC1 0.59 8.42 0.42 1.12e-15 Fuchs's corneal dystrophy; LUSC trans rs7939886 0.920 rs80232778 chr11:55970655 G/A cg03929089 chr4:120376271 NA 0.82 6.19 0.32 1.79e-9 Myopia (pathological); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19710302 chr4:56915651 NA 0.43 6.22 0.32 1.47e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg22655196 chr4:3374909 RGS12 0.32 6.24 0.32 1.32e-9 Serum sulfate level; LUSC trans rs2832077 0.943 rs4816336 chr21:30193519 C/T cg14791747 chr16:20752902 THUMPD1 0.73 9.55 0.46 2.84e-19 Cognitive test performance; LUSC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -5.99 -0.31 5.49e-9 Total body bone mineral density; LUSC cis rs4930103 0.935 rs2525881 chr11:2019333 T/C cg23202291 chr11:1979235 NA 0.39 6.1 0.32 2.96e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs8072100 0.967 rs7221548 chr17:45582952 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 0.34 5.73 0.3 2.19e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3770081 0.793 rs74743393 chr2:86227421 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -1.09 -6.81 -0.35 4.43e-11 Facial emotion recognition (sad faces); LUSC trans rs1422110 0.718 rs10079231 chr5:85439369 A/G cg01787110 chr1:109008453 NBPF6 0.56 9.31 0.45 1.7e-18 Attention function in attention deficit hyperactive disorder; LUSC cis rs17253792 0.822 rs10143002 chr14:56074278 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.16 -0.36 5.08e-12 Putamen volume; LUSC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg20744362 chr22:50050164 C22orf34 0.39 8.01 0.4 1.96e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg22508957 chr16:3507546 NAT15 -0.41 -6.52 -0.34 2.67e-10 Body mass index (adult); LUSC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg01579765 chr21:45077557 HSF2BP -0.52 -11.1 -0.52 1.41e-24 Mean corpuscular volume; LUSC trans rs7939886 0.920 rs60087290 chr11:55983527 C/G cg15704280 chr7:45808275 SEPT13 0.9 6.77 0.35 5.92e-11 Myopia (pathological); LUSC cis rs72781680 0.898 rs72786288 chr2:24075416 G/T cg08917208 chr2:24149416 ATAD2B 0.87 9.84 0.47 3.11e-20 Lymphocyte counts; LUSC cis rs11764590 0.694 rs10276536 chr7:2086960 C/T cg19629631 chr7:2060116 MAD1L1 -0.34 -5.79 -0.3 1.62e-8 Neuroticism; LUSC cis rs9309473 0.660 rs62151564 chr2:73615449 A/G cg20560298 chr2:73613845 ALMS1 -0.53 -6.16 -0.32 2.14e-9 Metabolite levels; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.13 -0.32 2.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs12195417 0.563 rs496148 chr6:84217801 G/A cg08257003 chr6:84140564 ME1 -0.28 -6.55 -0.34 2.12e-10 Schizophrenia; LUSC cis rs9462027 0.628 rs2395604 chr6:34787976 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.74 -0.3 2.1e-8 Systemic lupus erythematosus; LUSC cis rs926938 0.527 rs360666 chr1:115481290 C/T cg12756093 chr1:115239321 AMPD1 0.45 6.86 0.35 3.28e-11 Autism; LUSC cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg03433033 chr1:76189801 ACADM -0.48 -7.28 -0.37 2.43e-12 Daytime sleep phenotypes; LUSC cis rs16912285 0.539 rs11027824 chr11:24368141 A/G ch.11.24196551F chr11:24239977 NA 0.66 6.07 0.32 3.48e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg05343316 chr1:45956843 TESK2 0.63 9.15 0.45 5.72e-18 Platelet count; LUSC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg22800045 chr5:56110881 MAP3K1 0.44 6.03 0.31 4.32e-9 Coronary artery disease; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg02796970 chr10:39023768 NA -0.48 -7.74 -0.39 1.16e-13 Menopause (age at onset); LUSC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg09491104 chr22:46646882 C22orf40 -0.64 -7.38 -0.37 1.23e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg06671706 chr8:8559999 CLDN23 0.46 6.35 0.33 7.21e-10 Obesity-related traits; LUSC cis rs12594515 1.000 rs12906442 chr15:45985254 C/A cg01629716 chr15:45996671 NA 0.4 5.97 0.31 5.99e-9 Waist circumference;Weight; LUSC cis rs9467773 0.869 rs9295689 chr6:26455811 T/C cg12292205 chr6:26970375 C6orf41 0.38 6.04 0.31 4.1e-9 Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg06022373 chr22:39101656 GTPBP1 0.8 12.59 0.57 5.15e-30 Menopause (age at onset); LUSC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.07 0.48 5.33e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2282802 0.660 rs2436390 chr5:139586501 G/A cg26211634 chr5:139558579 C5orf32 -0.42 -7.95 -0.4 2.96e-14 Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg18681998 chr4:17616180 MED28 0.85 15.92 0.66 7.1e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.4 0.33 5.39e-10 Menopause (age at onset); LUSC trans rs17685 0.753 rs1639609 chr7:75683581 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 19.83 0.74 2.22e-58 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs12902680 0.706 rs12440622 chr15:46525624 C/T cg04321580 chr8:143696133 ARC -0.42 -6.0 -0.31 5e-9 Neuroticism; LUSC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg06212747 chr3:49208901 KLHDC8B -0.48 -6.46 -0.33 3.79e-10 Parkinson's disease; LUSC cis rs1577917 0.839 rs1596990 chr6:86550692 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.29 -0.33 9.98e-10 Response to antipsychotic treatment; LUSC cis rs9303401 0.659 rs17822807 chr17:56687190 A/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.08 0.45 9.54e-18 Cognitive test performance; LUSC cis rs34172651 0.917 rs11074651 chr16:24778409 A/G cg06028605 chr16:24865363 SLC5A11 0.47 8.62 0.43 2.68e-16 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.13 0.32 2.44e-9 Bipolar disorder; LUSC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg24578937 chr1:2090814 PRKCZ -0.41 -9.1 -0.45 8.37e-18 Height; LUSC cis rs10089 0.953 rs1432615 chr5:127395371 G/A cg19767477 chr5:127420684 SLC12A2 -0.4 -5.74 -0.3 2.12e-8 Ileal carcinoids; LUSC cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg26898376 chr11:64110657 CCDC88B 0.36 6.9 0.35 2.6e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg04362960 chr10:104952993 NT5C2 -0.49 -6.49 -0.33 3.15e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9341808 0.667 rs2505944 chr6:80888410 T/C cg08355045 chr6:80787529 NA 0.47 8.14 0.41 7.73e-15 Sitting height ratio; LUSC cis rs6494488 0.500 rs72742968 chr15:64919920 A/T cg08069370 chr15:64387884 SNX1 -0.65 -5.78 -0.3 1.75e-8 Coronary artery disease; LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg01802117 chr1:53393560 SCP2 0.38 6.21 0.32 1.53e-9 Monocyte count; LUSC cis rs1580019 0.520 rs13228793 chr7:32711465 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.96 13.2 0.59 2.67e-32 Cognitive ability; LUSC cis rs870825 0.860 rs2705899 chr4:185596219 A/G cg04058563 chr4:185651563 MLF1IP 0.77 11.19 0.52 6.74e-25 Blood protein levels; LUSC cis rs6964587 0.626 rs2188841 chr7:91522641 A/G cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.66e-18 Breast cancer; LUSC trans rs1005277 0.579 rs2472183 chr10:38392495 T/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg06028605 chr16:24865363 SLC5A11 0.42 6.76 0.35 6.15e-11 Intelligence (multi-trait analysis); LUSC trans rs1997103 0.906 rs4618644 chr7:55402037 T/G cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg11062466 chr8:58055876 NA 0.67 8.06 0.4 1.4e-14 Developmental language disorder (linguistic errors); LUSC cis rs7833986 0.501 rs2953910 chr8:56968761 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.54 0.57 7.75e-30 Height; LUSC cis rs4285028 0.656 rs2141487 chr3:121482765 A/G cg11130432 chr3:121712080 ILDR1 0.62 9.17 0.45 5.02e-18 Multiple sclerosis; LUSC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg17443473 chr1:3703550 LRRC47 0.32 5.69 0.3 2.78e-8 Red cell distribution width; LUSC cis rs2486288 0.656 rs8039354 chr15:45551756 A/G cg04036182 chr15:45458818 NA 0.35 5.72 0.3 2.33e-8 Glomerular filtration rate; LUSC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg24675658 chr1:53192096 ZYG11B -0.64 -10.1 -0.48 4.12e-21 Monocyte count; LUSC cis rs62027291 0.950 rs62027293 chr15:77269918 G/C cg26408565 chr15:76604113 ETFA 0.48 5.65 0.3 3.43e-8 Plateletcrit; LUSC cis rs11792861 0.589 rs75742991 chr9:111929624 C/G cg13535736 chr9:111863775 C9orf5 -0.43 -6.93 -0.35 2.16e-11 Menarche (age at onset); LUSC cis rs17818399 0.926 rs1378764 chr2:46839681 C/T cg02822958 chr2:46747628 ATP6V1E2 0.39 6.05 0.31 3.87e-9 Height; LUSC cis rs113835537 0.529 rs11824771 chr11:66262550 T/C cg24851651 chr11:66362959 CCS 0.55 8.15 0.41 7.63e-15 Airway imaging phenotypes; LUSC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.52 -0.46 3.65e-19 Chronic sinus infection; LUSC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg19346786 chr7:2764209 NA -0.49 -8.52 -0.42 5.47e-16 Height; LUSC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg08847533 chr14:75593920 NEK9 -0.79 -13.4 -0.59 4.55e-33 Height; LUSC trans rs11098499 0.779 rs7699346 chr4:120310542 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.02 0.4 1.82e-14 Corneal astigmatism; LUSC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg24209194 chr3:40518798 ZNF619 0.49 6.42 0.33 4.63e-10 Renal cell carcinoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23397993 chr18:29598919 RNF125 0.72 6.23 0.32 1.39e-9 Cognitive performance; LUSC trans rs57221529 0.766 rs12521988 chr5:556421 C/T cg11887960 chr12:57824829 NA 0.55 7.21 0.37 3.7e-12 Lung disease severity in cystic fibrosis; LUSC cis rs1267303 0.675 rs1267312 chr1:46986748 C/G cg25110126 chr1:46999211 NA -0.56 -7.55 -0.38 4.16e-13 Monobrow; LUSC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg05347473 chr6:146136440 FBXO30 0.55 9.59 0.46 2.08e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg25072359 chr17:41440525 NA 0.65 9.11 0.45 7.81e-18 Menopause (age at onset); LUSC cis rs7568458 0.905 rs6547620 chr2:85755928 C/T cg17127132 chr2:85788382 GGCX 0.47 7.66 0.39 2.03e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.44 6.22 0.32 1.48e-9 Breast cancer; LUSC trans rs7824557 0.603 rs11250130 chr8:11214455 C/T cg08975724 chr8:8085496 FLJ10661 -0.52 -7.65 -0.39 2.2e-13 Retinal vascular caliber; LUSC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg17143192 chr8:8559678 CLDN23 0.59 8.43 0.42 1.07e-15 Obesity-related traits; LUSC cis rs9372498 0.536 rs72954806 chr6:118899965 C/G cg18833306 chr6:118973337 C6orf204 -0.45 -5.78 -0.3 1.67e-8 Diastolic blood pressure; LUSC cis rs2898290 0.540 rs35005793 chr8:11450472 G/A cg21175976 chr8:11421337 BLK 0.38 6.42 0.33 4.66e-10 Systolic blood pressure; LUSC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.78 -9.22 -0.45 3.45e-18 Mean platelet volume; LUSC cis rs478304 0.627 rs11604568 chr11:65511336 G/A cg27068330 chr11:65405492 SIPA1 -0.76 -10.92 -0.51 5.9e-24 Acne (severe); LUSC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg04518342 chr5:131593106 PDLIM4 0.36 6.47 0.33 3.58e-10 Breast cancer;Mosquito bite size; LUSC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg17330251 chr7:94953956 PON1 -0.36 -5.84 -0.3 1.22e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs11250098 0.503 rs7821826 chr8:10769439 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -7.39 -0.37 1.16e-12 Morning vs. evening chronotype; LUSC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg00745463 chr17:30367425 LRRC37B -0.87 -10.23 -0.49 1.46e-21 Hip circumference adjusted for BMI; LUSC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg26587870 chr6:27730563 NA -0.67 -6.01 -0.31 4.99e-9 Depression; LUSC trans rs9929218 0.954 rs12928043 chr16:68828885 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -10.6 -0.5 7.72e-23 Colorectal cancer; LUSC trans rs6557876 1.000 rs1008974 chr8:25904488 G/T cg20465333 chr22:32061711 NA 0.43 6.15 0.32 2.21e-9 Systolic blood pressure; LUSC cis rs10504073 0.584 rs7818507 chr8:49918423 G/T cg00325661 chr8:49890786 NA 0.69 11.06 0.52 1.87e-24 Blood metabolite ratios; LUSC cis rs9677476 0.863 rs11558174 chr2:232072912 T/C cg07929768 chr2:232055508 NA 0.37 7.11 0.36 7.2e-12 Food antigen IgG levels; LUSC cis rs3806843 1.000 rs4151680 chr5:140186657 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs877282 0.853 rs7069720 chr10:754487 A/G cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg19875535 chr5:140030758 IK 0.47 7.64 0.39 2.37e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg18357526 chr6:26021779 HIST1H4A 0.42 6.78 0.35 5.35e-11 Intelligence (multi-trait analysis); LUSC trans rs76248362 0.881 rs7997131 chr13:24438807 A/G cg26511321 chr7:27196790 HOXA7 0.53 6.18 0.32 1.91e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs748404 0.697 rs554001 chr15:43551919 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.49 0.42 6.83e-16 Lung cancer; LUSC cis rs4466137 0.953 rs6869030 chr5:83007311 C/T cg15083037 chr5:83017644 HAPLN1 -0.6 -7.91 -0.4 3.8e-14 Prostate cancer; LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg08736216 chr1:53307985 ZYG11A 0.3 6.19 0.32 1.81e-9 Monocyte count; LUSC cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg03676636 chr4:99064102 C4orf37 0.37 8.08 0.4 1.18e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg06145435 chr7:1022769 CYP2W1 0.31 6.54 0.34 2.36e-10 Longevity;Endometriosis; LUSC cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 7.39 0.37 1.19e-12 Rheumatoid arthritis; LUSC cis rs7246657 0.943 rs10414904 chr19:37830088 G/A cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs6942756 1.000 rs6942756 chr7:128886821 T/G cg02491457 chr7:128862824 NA -0.52 -7.42 -0.38 9.94e-13 White matter hyperintensity burden; LUSC cis rs425277 1.000 rs262665 chr1:2083173 A/G cg03732007 chr1:2071316 PRKCZ 0.48 7.81 0.39 7.71e-14 Height; LUSC cis rs1018697 0.518 rs284843 chr10:104553566 C/T cg04362960 chr10:104952993 NT5C2 -0.65 -7.65 -0.39 2.18e-13 Colorectal adenoma (advanced); LUSC cis rs9790314 1.000 rs6765269 chr3:160948542 T/C cg04691961 chr3:161091175 C3orf57 -0.36 -6.09 -0.32 3.16e-9 Morning vs. evening chronotype; LUSC cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -8.93 -0.44 2.87e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.68 -0.47 1.08e-19 Prostate cancer; LUSC cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg09184832 chr6:79620586 NA -0.42 -6.8 -0.35 4.71e-11 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg05425664 chr17:57184151 TRIM37 0.52 7.71 0.39 1.49e-13 Intelligence (multi-trait analysis); LUSC cis rs225245 0.791 rs720774 chr17:34017453 T/G cg05299278 chr17:33885742 SLFN14 0.29 6.34 0.33 7.44e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.35 -0.37 1.5e-12 Menarche (age at onset); LUSC cis rs9283706 0.562 rs10471697 chr5:66328555 A/T cg11590213 chr5:66331682 MAST4 0.47 7.13 0.36 6.3e-12 Coronary artery disease; LUSC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -7.87 -0.4 5.01e-14 Hemoglobin concentration; LUSC cis rs7809950 0.723 rs62483634 chr7:106878516 G/A cg23024343 chr7:107201750 COG5 -0.65 -9.78 -0.47 5.1e-20 Coronary artery disease; LUSC cis rs250677 0.958 rs36068 chr5:148417512 C/T cg12140854 chr5:148520817 ABLIM3 -0.36 -5.88 -0.31 9.93e-9 Breast cancer; LUSC cis rs7903847 0.596 rs869967 chr10:99147975 T/C cg08345082 chr10:99160200 RRP12 -0.35 -7.17 -0.37 4.77e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg26924012 chr15:45694286 SPATA5L1 1.14 20.41 0.75 1.08e-60 Homoarginine levels; LUSC cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg11189052 chr15:85197271 WDR73 -0.49 -6.2 -0.32 1.65e-9 Schizophrenia; LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg18099408 chr3:52552593 STAB1 -0.42 -7.24 -0.37 3.18e-12 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12234426 chr4:2965388 GRK4;NOP14 -0.46 -7.0 -0.36 1.45e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg14552801 chr7:65878734 NA -0.44 -6.22 -0.32 1.51e-9 Aortic root size; LUSC cis rs1595825 0.891 rs17520121 chr2:198898718 T/G cg00982548 chr2:198649783 BOLL -0.56 -7.05 -0.36 1.06e-11 Ulcerative colitis; LUSC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg07741184 chr6:167504864 NA 0.43 7.59 0.38 3.18e-13 Crohn's disease; LUSC cis rs834603 0.575 rs1620852 chr7:47481786 A/T cg09696706 chr7:47479511 TNS3 0.35 6.25 0.32 1.24e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC trans rs4332037 0.538 rs4721164 chr7:1932629 C/G cg10840412 chr1:235813424 GNG4 0.44 6.42 0.33 4.81e-10 Bipolar disorder; LUSC cis rs9611565 0.921 rs2281332 chr22:41746212 T/C cg03806693 chr22:41940476 POLR3H -0.72 -10.62 -0.5 6.59e-23 Vitiligo; LUSC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.23 -0.32 1.38e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg13010199 chr12:38710504 ALG10B -0.7 -11.56 -0.53 3.2e-26 Heart rate; LUSC cis rs1790761 0.554 rs12787511 chr11:67401635 G/C cg08355456 chr11:67383691 NA -0.38 -6.42 -0.33 4.63e-10 Mean corpuscular volume; LUSC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg13607699 chr17:42295918 UBTF 0.49 7.62 0.38 2.71e-13 Total body bone mineral density; LUSC cis rs9814567 1.000 rs9854299 chr3:134206728 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.85 -14.33 -0.62 1.22e-36 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg15605315 chr1:45957053 TESK2 0.51 8.59 0.43 3.41e-16 High light scatter reticulocyte count; LUSC cis rs9443645 0.527 rs9361477 chr6:79710806 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.91 -0.31 8.46e-9 Intelligence (multi-trait analysis); LUSC cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg04362960 chr10:104952993 NT5C2 -0.64 -10.01 -0.48 8.11e-21 Arsenic metabolism; LUSC cis rs10875746 0.807 rs12313300 chr12:48470717 G/A cg13454099 chr12:49076203 C12orf41 -0.5 -5.71 -0.3 2.47e-8 Longevity (90 years and older); LUSC cis rs2290416 0.892 rs3793369 chr8:144664335 G/A cg14809332 chr8:144654887 C8orf73 0.51 6.43 0.33 4.36e-10 Attention deficit hyperactivity disorder; LUSC cis rs4692589 0.606 rs13127322 chr4:170935169 C/T cg19918862 chr4:170955249 NA 0.4 7.13 0.36 6.11e-12 Anxiety disorder; LUSC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg22903471 chr2:27725779 GCKR -0.41 -6.82 -0.35 4.23e-11 Total body bone mineral density; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg26354017 chr1:205819088 PM20D1 0.95 19.87 0.74 1.49e-58 Menarche (age at onset); LUSC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg13175981 chr1:150552382 MCL1 0.48 6.81 0.35 4.53e-11 Tonsillectomy; LUSC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg04450456 chr4:17643702 FAM184B -0.42 -6.99 -0.36 1.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs3733585 0.673 rs6840802 chr4:9965633 C/G cg26043149 chr18:55253948 FECH 0.47 6.97 0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs965469 0.895 rs6051844 chr20:3402674 G/T cg25506879 chr20:3388711 C20orf194 0.52 6.3 0.33 9.2e-10 IFN-related cytopenia; LUSC trans rs4927850 0.881 rs7630489 chr3:195753401 T/C cg16724585 chr3:197361211 NA -0.62 -8.77 -0.43 9.17e-17 Pancreatic cancer; LUSC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg17252645 chr8:143867129 LY6D 0.38 6.67 0.34 1.06e-10 Urinary tract infection frequency; LUSC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg00376283 chr12:123451042 ABCB9 0.7 9.99 0.48 9.55e-21 Height;Educational attainment;Head circumference (infant); LUSC cis rs7909074 0.831 rs11239271 chr10:45376294 A/G cg04218760 chr10:45406644 TMEM72 -0.29 -6.99 -0.36 1.53e-11 Mean corpuscular volume; LUSC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.73 -13.31 -0.59 9.94e-33 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg13607699 chr17:42295918 UBTF 0.55 8.37 0.42 1.62e-15 Total body bone mineral density; LUSC cis rs10078 0.515 rs2672739 chr5:443447 A/C cg08916839 chr5:415575 AHRR 0.74 7.04 0.36 1.07e-11 Fat distribution (HIV); LUSC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg11663144 chr21:46675770 NA -0.43 -7.64 -0.39 2.25e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg27494647 chr7:150038898 RARRES2 0.48 7.2 0.37 4.12e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs12618769 0.652 rs6736755 chr2:99204428 A/G cg10123293 chr2:99228465 UNC50 -0.43 -6.87 -0.35 3.13e-11 Bipolar disorder; LUSC cis rs60843830 0.508 rs300750 chr2:208794 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.38 5.89 0.31 9.44e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs72960926 0.590 rs11754945 chr6:74732673 A/C cg03266952 chr6:74778945 NA 0.76 6.32 0.33 8.5e-10 Metabolite levels (MHPG); LUSC cis rs17270561 0.562 rs12199626 chr6:26013604 G/A cg17042849 chr6:26104293 HIST1H4C -0.65 -7.42 -0.38 9.95e-13 Iron status biomarkers; LUSC cis rs1524927 1.000 rs12704872 chr7:96334616 T/C cg03808172 chr7:96339361 SHFM1 0.43 6.65 0.34 1.21e-10 Total body bone mineral density; LUSC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg05425664 chr17:57184151 TRIM37 -0.59 -9.02 -0.44 1.52e-17 Intelligence (multi-trait analysis); LUSC trans rs9467711 0.659 rs3823158 chr6:26463271 T/A cg06606381 chr12:133084897 FBRSL1 -0.7 -6.25 -0.32 1.26e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg19318889 chr4:1322082 MAEA 0.47 7.64 0.39 2.28e-13 Obesity-related traits; LUSC cis rs2742417 1.000 rs2742390 chr3:45756722 A/G cg09608765 chr3:45636137 LIMD1 0.35 7.06 0.36 9.51e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.8 0.3 1.5e-8 Self-reported allergy; LUSC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg00745463 chr17:30367425 LRRC37B 0.89 9.13 0.45 6.79e-18 Hip circumference adjusted for BMI; LUSC cis rs12044355 0.927 rs61835382 chr1:231833225 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.39 5.66 0.3 3.23e-8 Alzheimer's disease; LUSC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.37e-34 Diabetic kidney disease; LUSC trans rs4650994 0.544 rs2476561 chr1:178619900 C/T cg05059571 chr16:84539110 KIAA1609 -0.47 -9.04 -0.44 1.27e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs500891 0.533 rs9968948 chr6:84185074 G/A cg08257003 chr6:84140564 ME1 0.33 7.97 0.4 2.58e-14 Platelet-derived growth factor BB levels; LUSC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg12311346 chr5:56204834 C5orf35 -1.01 -14.59 -0.62 1.22e-37 Initial pursuit acceleration; LUSC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg06808227 chr14:105710500 BRF1 -0.67 -10.32 -0.49 7.67e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs7084921 0.578 rs12765808 chr10:101872687 A/C cg11888571 chr10:102027403 CWF19L1 -0.45 -6.07 -0.32 3.44e-9 Bone mineral density; LUSC cis rs2857891 0.773 rs2857900 chr11:6980536 T/C cg14883916 chr11:6947541 ZNF215 0.44 5.82 0.3 1.37e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs9527 0.622 rs12779263 chr10:104886533 G/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.33 -0.33 7.69e-10 Arsenic metabolism; LUSC cis rs17102423 0.661 rs4468529 chr14:65611968 C/T cg11161011 chr14:65562177 MAX -0.71 -9.62 -0.47 1.75e-19 Obesity-related traits; LUSC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg18252515 chr7:66147081 NA -1.23 -13.55 -0.6 1.24e-33 Diabetic kidney disease; LUSC cis rs9650657 0.571 rs4240673 chr8:10787612 T/C cg27411982 chr8:10470053 RP1L1 -0.5 -7.96 -0.4 2.66e-14 Neuroticism; LUSC cis rs472402 0.507 rs8192139 chr5:6636973 C/G cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.48 -7.18 -0.37 4.51e-12 Response to amphetamines; LUSC cis rs3743162 0.553 rs12900463 chr15:85415386 T/C cg12863693 chr15:85201151 NMB 0.31 5.89 0.31 9.58e-9 Alzheimer's disease (age of onset); LUSC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg21918786 chr6:109611834 NA -0.4 -6.86 -0.35 3.42e-11 Reticulocyte fraction of red cells; LUSC cis rs6931421 1.000 rs6931421 chr6:80880138 A/C cg08355045 chr6:80787529 NA 0.58 9.24 0.45 2.93e-18 Sitting height ratio; LUSC cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg26384229 chr12:38710491 ALG10B 0.86 14.0 0.61 2.4e-35 Bladder cancer; LUSC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg27121462 chr16:89883253 FANCA 0.56 8.97 0.44 2.23e-17 Vitiligo; LUSC cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg18681998 chr4:17616180 MED28 -0.84 -14.53 -0.62 2.09e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg23711669 chr6:146136114 FBXO30 0.94 18.6 0.71 1.75e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12681287 0.888 rs2976201 chr8:87335937 T/C cg27223183 chr8:87520930 FAM82B -0.49 -6.83 -0.35 3.94e-11 Caudate activity during reward; LUSC cis rs2991971 1.000 rs2991972 chr1:46013208 C/T cg15605315 chr1:45957053 TESK2 0.46 7.31 0.37 2.04e-12 High light scatter reticulocyte count; LUSC cis rs11098499 0.562 rs58583086 chr4:120556362 A/G cg24375607 chr4:120327624 NA -0.63 -10.13 -0.48 3.25e-21 Corneal astigmatism; LUSC cis rs7575217 0.784 rs2241872 chr2:101768774 G/C cg23907051 chr2:101730305 TBC1D8 -0.3 -7.98 -0.4 2.35e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs1018836 0.923 rs6998150 chr8:91645969 A/C cg16814680 chr8:91681699 NA -0.78 -12.87 -0.58 4.76e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -8.0 -0.4 2.02e-14 Height; LUSC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg10053473 chr17:62856997 LRRC37A3 0.64 10.18 0.49 2.22e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs6773957 1.000 rs6773957 chr3:186573705 C/T cg01963189 chr4:121613795 NA 0.33 6.02 0.31 4.59e-9 Adiponectin levels; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2243480 1.000 rs34933526 chr7:65383199 A/G cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs34779708 1.000 rs34779708 chr10:35466185 T/G cg04310649 chr10:35416472 CREM -0.4 -6.27 -0.32 1.11e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6669919 0.553 rs11587632 chr1:211668437 T/C cg10512769 chr1:211675356 NA -0.3 -7.06 -0.36 9.61e-12 Intelligence (multi-trait analysis); LUSC cis rs12210905 1.000 rs12192446 chr6:26995638 C/A cg23155468 chr6:27110703 HIST1H2BK -0.7 -5.94 -0.31 7.29e-9 Hip circumference adjusted for BMI; LUSC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg16586182 chr3:47516702 SCAP -0.51 -8.17 -0.41 6.57e-15 Colorectal cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02050560 chr22:42486888 NDUFA6 -0.49 -6.42 -0.33 4.66e-10 Bipolar disorder and schizophrenia; LUSC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg12963246 chr6:28129442 ZNF389 0.43 6.53 0.34 2.45e-10 Parkinson's disease; LUSC trans rs3749237 0.964 rs35210174 chr3:49812606 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.99 0.36 1.53e-11 Resting heart rate; LUSC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.06e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg16132339 chr22:24313637 DDTL;DDT 0.42 6.53 0.34 2.4e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg24503407 chr1:205819492 PM20D1 -0.43 -6.13 -0.32 2.49e-9 Parkinson's disease; LUSC cis rs12618769 0.597 rs4069739 chr2:99049528 G/C cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg25072359 chr17:41440525 NA 0.65 9.46 0.46 5.86e-19 Menopause (age at onset); LUSC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg20503657 chr10:835505 NA 0.96 13.03 0.58 1.21e-31 Eosinophil percentage of granulocytes; LUSC cis rs6667605 0.506 rs10797440 chr1:2541269 A/G cg18854424 chr1:2615690 NA 0.52 10.83 0.51 1.22e-23 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.68 10.42 0.5 3.33e-22 Lymphocyte counts; LUSC cis rs7246967 0.551 rs12974117 chr19:22867876 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.01 0.31 4.91e-9 Bronchopulmonary dysplasia; LUSC cis rs3020736 0.500 rs6002614 chr22:42501802 G/A cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg16745616 chr19:8428856 ANGPTL4 -0.4 -6.03 -0.31 4.41e-9 HDL cholesterol; LUSC cis rs9359856 0.957 rs9362666 chr6:90310345 T/C cg13799429 chr6:90582589 CASP8AP2 0.59 6.92 0.35 2.31e-11 Bipolar disorder; LUSC cis rs9611565 0.918 rs28638318 chr22:41753059 G/A cg03806693 chr22:41940476 POLR3H -0.85 -11.41 -0.53 1.1e-25 Vitiligo; LUSC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.56 -7.5 -0.38 5.77e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.21 0.59 2.34e-32 Total body bone mineral density; LUSC cis rs4713675 0.584 rs942643 chr6:33668370 A/G cg14003231 chr6:33640908 ITPR3 0.31 5.96 0.31 6.53e-9 Plateletcrit; LUSC cis rs12541635 1.000 rs4734897 chr8:107075518 G/A cg10147462 chr8:107024639 NA -0.48 -8.62 -0.43 2.66e-16 Age of smoking initiation; LUSC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC trans rs877282 0.947 rs7475589 chr10:767479 C/G cg13042288 chr15:90349979 ANPEP -0.49 -7.03 -0.36 1.18e-11 Uric acid levels; LUSC cis rs2933343 0.700 rs876754 chr3:128627753 T/C cg11901034 chr3:128598214 ACAD9 -0.42 -6.61 -0.34 1.5e-10 IgG glycosylation; LUSC cis rs6964587 1.000 rs10234290 chr7:91716951 T/C cg01689657 chr7:91764605 CYP51A1 0.33 5.84 0.3 1.23e-8 Breast cancer; LUSC cis rs13006833 0.668 rs291445 chr2:191176479 G/A cg21644426 chr2:191273491 MFSD6 0.43 6.14 0.32 2.39e-9 Urinary metabolites; LUSC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg17376030 chr22:41985996 PMM1 -0.47 -5.81 -0.3 1.49e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg09469691 chr10:81107165 PPIF 0.59 8.9 0.44 3.5e-17 Height; LUSC cis rs6977660 0.607 rs13239423 chr7:19816571 T/C cg05791153 chr7:19748676 TWISTNB 0.7 7.42 0.38 9.51e-13 Thyroid stimulating hormone; LUSC cis rs9815354 0.812 rs60796012 chr3:41908668 T/C cg03022575 chr3:42003672 ULK4 0.83 8.67 0.43 1.88e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2108225 0.714 rs10953548 chr7:107436232 G/A cg18560240 chr7:107437656 SLC26A3 -0.43 -6.55 -0.34 2.14e-10 Ulcerative colitis; LUSC cis rs4953076 0.613 rs11124981 chr2:44462133 A/T cg04920474 chr2:44395004 PPM1B 0.6 7.83 0.39 6.75e-14 Height; LUSC cis rs9472414 0.771 rs720989 chr6:44765535 G/T cg20913747 chr6:44695427 NA -0.41 -5.71 -0.3 2.44e-8 Height; LUSC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg12288994 chr5:1860383 NA 0.29 6.3 0.33 9.33e-10 Cardiovascular disease risk factors; LUSC cis rs727505 0.564 rs4731236 chr7:124827236 G/T cg23710748 chr7:124431027 NA -0.39 -6.76 -0.35 6.12e-11 Lewy body disease; LUSC cis rs77216612 0.835 rs10845621 chr12:12887977 C/T cg09462578 chr12:12878428 APOLD1 -0.98 -16.98 -0.68 4.89e-47 Lymphocyte counts; LUSC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg01741372 chr11:783889 NA -0.57 -10.63 -0.5 6.53e-23 Breast cancer; LUSC cis rs2294693 1.000 rs2294693 chr6:41005502 T/C cg14769373 chr6:40998127 UNC5CL -0.56 -7.91 -0.4 3.76e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs4240897 1.000 rs4240897 chr1:12042755 A/G cg13216073 chr1:12042593 MFN2 -0.38 -6.5 -0.34 2.88e-10 Tuberculosis; LUSC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg03804128 chr16:635623 NA 0.31 6.22 0.32 1.51e-9 Height; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg22943607 chr19:4400723 SH3GL1 0.42 6.06 0.31 3.65e-9 Mosquito bite size; LUSC cis rs67460515 0.892 rs11711413 chr3:160998910 C/G cg03342759 chr3:160939853 NMD3 -0.54 -8.01 -0.4 1.88e-14 Parkinson's disease; LUSC cis rs7267979 0.966 rs2387885 chr20:25415224 G/A cg03522245 chr20:25566470 NINL -0.35 -5.78 -0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg07362569 chr17:61921086 SMARCD2 -0.37 -7.55 -0.38 4.1e-13 Prudent dietary pattern; LUSC cis rs6782228 0.675 rs2253151 chr3:128330137 T/C cg16766828 chr3:128327626 NA -0.31 -5.71 -0.3 2.49e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg11366901 chr6:160182831 ACAT2 0.92 12.83 0.57 6.56e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg00031303 chr3:195681400 NA 0.63 9.17 0.45 4.83e-18 Pancreatic cancer; LUSC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg13902645 chr11:5959945 NA -0.57 -8.03 -0.4 1.64e-14 DNA methylation (variation); LUSC cis rs12291225 0.679 rs11605531 chr11:14291594 A/G cg19336497 chr11:14380999 RRAS2 -0.58 -12.02 -0.55 6.94e-28 Sense of smell; LUSC cis rs8028313 0.630 rs3784700 chr15:68017752 A/G cg05925327 chr15:68127851 NA -0.44 -6.89 -0.35 2.79e-11 Obesity; LUSC cis rs977987 0.806 rs17696696 chr16:75393352 G/T cg03315344 chr16:75512273 CHST6 -0.48 -9.17 -0.45 4.91e-18 Dupuytren's disease; LUSC cis rs7614311 0.731 rs73117087 chr3:63948696 A/G cg22134162 chr3:63841271 THOC7 -0.48 -5.92 -0.31 8.11e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg12310025 chr6:25882481 NA -0.53 -8.97 -0.44 2.12e-17 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9486719 0.947 rs12213375 chr6:96902134 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -10.02 -0.48 7.88e-21 Migraine;Coronary artery disease; LUSC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg02073558 chr3:44770973 ZNF501 0.6 9.92 0.48 1.69e-20 Depressive symptoms; LUSC trans rs8072100 0.790 rs3760371 chr17:45695914 T/C cg03886242 chr7:26192032 NFE2L3 0.41 6.49 0.33 3.03e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7267979 1.000 rs2482931 chr20:25334445 G/A cg03522245 chr20:25566470 NINL -0.35 -5.72 -0.3 2.36e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6121246 0.529 rs6060210 chr20:30187681 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg27279351 chr12:120934652 DYNLL1 0.63 8.41 0.42 1.21e-15 High light scatter reticulocyte count; LUSC cis rs7149337 0.780 rs4369569 chr14:51689181 C/G cg23942311 chr14:51606299 NA -0.55 -12.09 -0.55 3.57e-28 Cancer; LUSC cis rs2072499 0.833 rs2251847 chr1:156204047 G/A cg24450063 chr1:156163899 SLC25A44 1.08 21.15 0.76 1.37e-63 Testicular germ cell tumor; LUSC cis rs2857891 0.773 rs2857897 chr11:6982082 A/C cg04053776 chr11:6947353 ZNF215 0.42 5.98 0.31 5.62e-9 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs11088226 0.681 rs2833901 chr21:33939318 T/C cg09050820 chr6:167586206 TCP10L2 0.73 9.47 0.46 5.31e-19 Gastritis; LUSC cis rs6121246 0.821 rs6058448 chr20:30332396 C/T cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC trans rs877282 0.786 rs11253392 chr10:788768 G/A cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19717193 chr7:105162577 PUS7 -0.51 -6.24 -0.32 1.35e-9 Bipolar disorder and schizophrenia; LUSC cis rs4499344 0.556 rs259228 chr19:33134635 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.95 14.03 0.61 1.78e-35 Mean platelet volume; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg07167872 chr1:205819463 PM20D1 0.77 14.96 0.63 4.26e-39 Monocyte percentage of white cells; LUSC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg23630131 chr7:65973040 NA -0.21 -6.01 -0.31 4.93e-9 Aortic root size; LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.89 -0.58 3.92e-31 Alzheimer's disease; LUSC cis rs1670533 0.872 rs10017931 chr4:1060747 G/A cg27284194 chr4:1044797 NA 0.6 8.9 0.44 3.71e-17 Recombination rate (females); LUSC trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg21775007 chr8:11205619 TDH 0.5 7.44 0.38 8.37e-13 Neuroticism; LUSC cis rs7264396 0.790 rs6058293 chr20:34248891 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.82 -0.47 3.7e-20 Total cholesterol levels; LUSC cis rs9309473 0.539 rs6745560 chr2:73827117 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -7.2 -0.37 4.02e-12 Metabolite levels; LUSC cis rs7914558 0.932 rs4307650 chr10:104959852 C/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.61 -0.34 1.53e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2976388 1.000 rs10216533 chr8:143763690 G/A cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg24550644 chr17:30846204 MYO1D 0.6 10.74 0.51 2.54e-23 Schizophrenia; LUSC cis rs72960926 0.744 rs72957983 chr6:74968228 A/G cg03266952 chr6:74778945 NA -0.72 -6.61 -0.34 1.56e-10 Metabolite levels (MHPG); LUSC cis rs11264799 0.603 rs12744410 chr1:157566211 A/G cg18268488 chr1:157545234 FCRL4 0.33 5.9 0.31 8.76e-9 IgA nephropathy; LUSC cis rs11155671 0.530 rs9397420 chr6:150206781 C/T cg04369109 chr6:150039330 LATS1 0.4 5.81 0.3 1.5e-8 Testicular germ cell tumor; LUSC cis rs9747201 1.000 rs9747668 chr17:80161081 A/G cg17462356 chr17:80056334 FASN -0.44 -6.08 -0.32 3.25e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg01283332 chr5:1856932 NA -0.37 -6.86 -0.35 3.31e-11 Cardiovascular disease risk factors; LUSC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22590775 chr19:49891494 CCDC155 0.56 7.32 0.37 1.92e-12 Multiple sclerosis; LUSC cis rs10911232 0.507 rs10911198 chr1:182997318 G/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg11387990 chr12:32260018 BICD1 0.42 6.03 0.31 4.24e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22713941 chr2:105953959 C2orf49 0.48 6.74 0.35 6.86e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10791323 0.604 rs2723605 chr11:133711241 C/G cg15485101 chr11:133734466 NA 0.4 7.24 0.37 3.03e-12 Childhood ear infection; LUSC cis rs11098499 0.866 rs10518329 chr4:120401835 A/G cg09307838 chr4:120376055 NA 0.65 10.08 0.48 4.7e-21 Corneal astigmatism; LUSC cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg13256891 chr4:100009986 ADH5 -0.45 -6.09 -0.32 3.17e-9 Alcohol dependence; LUSC cis rs9549367 0.789 rs2316442 chr13:113877487 C/T cg18105134 chr13:113819100 PROZ -0.71 -10.09 -0.48 4.47e-21 Platelet distribution width; LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC cis rs1728785 0.901 rs933713 chr16:68581378 C/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs2456568 0.508 rs1607403 chr11:93660514 A/G cg17595323 chr11:93583763 C11orf90 -0.31 -5.66 -0.3 3.3e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs5758659 0.652 rs133322 chr22:42405659 A/G cg04733989 chr22:42467013 NAGA 0.4 6.7 0.34 8.67e-11 Cognitive function; LUSC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.79 -0.39 8.31e-14 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg03036452 chr22:46663545 TTC38 0.58 5.76 0.3 1.88e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs60843830 0.596 rs17041320 chr2:112051 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.52 8.33 0.41 2.14e-15 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg02423579 chr7:2872169 GNA12 -0.38 -5.91 -0.31 8.38e-9 Height; LUSC cis rs7590368 1.000 rs55968911 chr2:10961840 C/T cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs807669 0.525 rs2073740 chr22:19196112 A/C cg02655711 chr22:19163373 SLC25A1 -0.49 -8.99 -0.44 1.81e-17 Metabolite levels; LUSC cis rs6121246 0.559 rs6060857 chr20:30300222 A/G cg13852791 chr20:30311386 BCL2L1 0.93 14.46 0.62 3.86e-37 Mean corpuscular hemoglobin; LUSC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg17554472 chr22:41940697 POLR3H -0.49 -5.87 -0.31 1.08e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg18240062 chr17:79603768 NPLOC4 -0.79 -15.33 -0.64 1.56e-40 Eye color traits; LUSC cis rs8062405 0.929 rs11150609 chr16:28870596 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6696846 0.777 rs6664397 chr1:205051871 C/T cg21643547 chr1:205240462 TMCC2 -0.38 -7.02 -0.36 1.23e-11 Red blood cell count; LUSC cis rs9325144 0.647 rs11169258 chr12:39113040 C/T cg13010199 chr12:38710504 ALG10B -0.5 -7.69 -0.39 1.62e-13 Morning vs. evening chronotype; LUSC cis rs243505 0.898 rs243527 chr7:148416104 G/T cg09806900 chr7:148480153 CUL1 -0.48 -6.82 -0.35 4.34e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC cis rs614226 0.935 rs7137953 chr12:120894685 C/T cg01236616 chr12:121019343 POP5 -1.32 -20.9 -0.75 1.26e-62 Type 1 diabetes nephropathy; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.83 -0.57 6.64e-31 Alzheimer's disease; LUSC trans rs1728785 0.892 rs4783562 chr16:68562963 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.71 0.39 1.46e-13 Ulcerative colitis; LUSC cis rs3741151 0.892 rs2027760 chr11:73036481 G/A cg17517138 chr11:73019481 ARHGEF17 0.97 9.08 0.44 1e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg00343986 chr7:65444356 GUSB 0.48 7.26 0.37 2.76e-12 Calcium levels; LUSC cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg05283184 chr6:79620031 NA -0.45 -8.48 -0.42 7.39e-16 Intelligence (multi-trait analysis); LUSC cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg15073853 chr19:18549131 ISYNA1 -0.31 -5.81 -0.3 1.44e-8 Breast cancer; LUSC cis rs9300255 0.550 rs10772997 chr12:123719880 C/A cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.78 -0.35 5.48e-11 Neutrophil percentage of white cells; LUSC cis rs344364 0.602 rs12325217 chr16:1887108 A/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.45 -6.78 -0.35 5.37e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg20503657 chr10:835505 NA 1.21 16.68 0.67 7.04e-46 Eosinophil percentage of granulocytes; LUSC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg25258033 chr6:167368657 RNASET2 0.48 7.92 0.4 3.55e-14 Crohn's disease; LUSC cis rs6502050 0.871 rs6502054 chr17:80066715 G/A cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.42e-8 Life satisfaction; LUSC cis rs1538970 0.851 rs2055145 chr1:45926495 C/G cg05343316 chr1:45956843 TESK2 0.68 9.48 0.46 4.95e-19 Platelet count; LUSC cis rs6121246 0.560 rs6088854 chr20:30225357 G/A cg13852791 chr20:30311386 BCL2L1 0.87 9.76 0.47 5.71e-20 Mean corpuscular hemoglobin; LUSC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg02574844 chr11:5959923 NA -0.42 -5.88 -0.31 1.01e-8 DNA methylation (variation); LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -10.73 -0.51 2.72e-23 Alzheimer's disease; LUSC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg02951883 chr7:2050386 MAD1L1 0.51 9.26 0.45 2.48e-18 Bipolar disorder and schizophrenia; LUSC cis rs3125734 0.572 rs7896627 chr10:64046354 T/G cg09941381 chr10:64027924 RTKN2 -0.39 -7.12 -0.36 6.51e-12 Rheumatoid arthritis; LUSC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.7e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs8113142 0.614 rs2098038 chr19:29192883 A/T cg04546413 chr19:29218101 NA 0.44 5.93 0.31 7.76e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.96 21.34 0.76 2.36e-64 Prudent dietary pattern; LUSC cis rs9925964 1.000 rs9925964 chr16:31129895 A/G cg02466173 chr16:30829666 NA 0.34 6.16 0.32 2.05e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs4824093 0.610 rs4141437 chr22:50243719 C/G cg22709217 chr22:50311962 ALG12;CRELD2 0.72 5.68 0.3 2.95e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs4964805 0.594 rs10861095 chr12:104165387 A/G cg02344784 chr12:104178138 NT5DC3 0.38 6.05 0.31 3.94e-9 Attention deficit hyperactivity disorder; LUSC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.59 -0.54 2.42e-26 Schizophrenia; LUSC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg17376030 chr22:41985996 PMM1 -0.47 -5.84 -0.3 1.25e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs10465746 0.725 rs1359331 chr1:84360301 C/A cg10977910 chr1:84465055 TTLL7 0.52 7.45 0.38 7.96e-13 Obesity-related traits; LUSC cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg13852791 chr20:30311386 BCL2L1 0.82 10.81 0.51 1.42e-23 Mean corpuscular hemoglobin; LUSC cis rs765787 0.530 rs2899381 chr15:45529630 C/T cg25801113 chr15:45476975 SHF 0.34 7.17 0.37 4.98e-12 Uric acid levels; LUSC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.2 0.32 1.71e-9 Schizophrenia; LUSC cis rs4654899 0.897 rs7548649 chr1:21090081 A/G cg01072550 chr1:21505969 NA -0.47 -7.06 -0.36 9.87e-12 Superior frontal gyrus grey matter volume; LUSC cis rs1577917 0.958 rs2324817 chr6:86462654 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.48 -0.33 3.39e-10 Response to antipsychotic treatment; LUSC cis rs1577917 0.958 rs1591438 chr6:86525214 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.78 -0.43 8.6e-17 Response to antipsychotic treatment; LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg04944784 chr2:26401820 FAM59B 0.77 11.17 0.52 7.75e-25 Gut microbiome composition (summer); LUSC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg06600287 chr1:53387719 ECHDC2 0.28 5.68 0.3 3.01e-8 Monocyte count; LUSC cis rs317689 0.600 rs478188 chr12:69639215 A/G cg11871910 chr12:69753446 YEATS4 0.45 5.83 0.3 1.3e-8 Response to diuretic therapy; LUSC cis rs5758659 0.652 rs133303 chr22:42395242 C/G cg04733989 chr22:42467013 NAGA 0.39 6.41 0.33 4.95e-10 Cognitive function; LUSC cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg19077165 chr18:44547161 KATNAL2 -0.42 -6.33 -0.33 7.76e-10 Personality dimensions; LUSC cis rs9837602 1.000 rs793499 chr3:99565576 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.06 -0.31 3.76e-9 Breast cancer; LUSC trans rs2204008 0.805 rs4589389 chr12:37946120 C/A cg06521331 chr12:34319734 NA 0.41 6.52 0.34 2.67e-10 Bladder cancer; LUSC cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg24558204 chr6:135376177 HBS1L 0.68 10.82 0.51 1.32e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg23630131 chr7:65973040 NA -0.2 -5.66 -0.3 3.22e-8 Aortic root size; LUSC cis rs6537837 0.887 rs1889470 chr1:110141421 A/G cg05049280 chr1:110155535 GNAT2 0.43 6.61 0.34 1.53e-10 Major depressive disorder; LUSC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg00800038 chr16:89945340 TCF25 -0.75 -6.64 -0.34 1.26e-10 Skin colour saturation; LUSC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg10664184 chr19:17420304 DDA1 0.47 5.81 0.3 1.48e-8 Systemic lupus erythematosus; LUSC cis rs4478858 0.735 rs11576603 chr1:31774031 C/T cg00250761 chr1:31883323 NA -0.35 -8.56 -0.42 4.19e-16 Alcohol dependence; LUSC trans rs6600671 1.000 rs6600671 chr1:121200490 T/G cg00646200 chr1:148855367 NA -0.49 -7.7 -0.39 1.59e-13 Hip geometry; LUSC cis rs1953600 0.837 rs2819946 chr10:81951635 G/A cg00277334 chr10:82204260 NA 0.45 7.08 0.36 8.35e-12 Sarcoidosis; LUSC trans rs9329221 0.662 rs11249996 chr8:10245463 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.58 -0.38 3.5e-13 Neuroticism; LUSC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg26314531 chr2:26401878 FAM59B 0.66 8.33 0.41 2.06e-15 Gut microbiome composition (summer); LUSC cis rs2562456 0.833 rs2562487 chr19:21651382 C/T cg00806126 chr19:22604979 ZNF98 -0.37 -5.78 -0.3 1.73e-8 Pain; LUSC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.35 -0.8 4.97e-76 Height; LUSC cis rs7799006 0.929 rs6461233 chr7:2261468 G/A cg12823233 chr7:2316876 SNX8 -0.35 -5.91 -0.31 8.25e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg13647721 chr17:30228624 UTP6 -0.63 -6.11 -0.32 2.85e-9 Hip circumference adjusted for BMI; LUSC cis rs2282300 0.739 rs1222215 chr11:30347596 C/T cg25418670 chr11:30344373 C11orf46 -0.64 -9.18 -0.45 4.63e-18 Morning vs. evening chronotype; LUSC cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg25427524 chr10:38739819 LOC399744 -0.59 -10.36 -0.49 5.26e-22 Extrinsic epigenetic age acceleration; LUSC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg12564285 chr5:131593104 PDLIM4 -0.44 -7.54 -0.38 4.45e-13 Breast cancer; LUSC cis rs10904908 0.733 rs7080366 chr10:17254832 C/T cg01003015 chr10:17271136 VIM -0.38 -5.65 -0.3 3.37e-8 Total cholesterol levels;Cholesterol, total; LUSC cis rs34779708 0.931 rs11010077 chr10:35328088 C/T cg03585969 chr10:35415529 CREM -0.57 -8.4 -0.42 1.27e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.69 -10.09 -0.48 4.37e-21 Systemic lupus erythematosus; LUSC cis rs3087591 0.960 rs10512433 chr17:29600564 T/C cg24425628 chr17:29625626 OMG;NF1 0.58 8.49 0.42 6.82e-16 Hip circumference; LUSC cis rs10892173 0.566 rs2298649 chr11:117672225 A/G cg21640587 chr11:117668038 DSCAML1 0.68 9.85 0.47 2.82e-20 Myopia; LUSC cis rs11690935 0.959 rs7572215 chr2:172634228 G/A cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.48 -0.62 3.25e-37 Schizophrenia; LUSC cis rs9549260 0.785 rs2253001 chr13:41145330 A/T cg21288729 chr13:41239152 FOXO1 0.6 9.24 0.45 2.89e-18 Red blood cell count; LUSC cis rs3931020 0.657 rs277369 chr1:75234661 T/C cg00121533 chr1:75199117 CRYZ;TYW3 -0.46 -5.87 -0.31 1.06e-8 Resistin levels; LUSC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg09455208 chr3:40491958 NA 0.59 10.51 0.5 1.59e-22 Renal cell carcinoma; LUSC cis rs6121246 0.559 rs6087779 chr20:30370566 T/C cg13852791 chr20:30311386 BCL2L1 0.95 14.88 0.63 9.12e-39 Mean corpuscular hemoglobin; LUSC cis rs877282 0.945 rs11253391 chr10:788752 G/A cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC trans rs11098499 0.710 rs6851130 chr4:120133712 G/A cg25214090 chr10:38739885 LOC399744 -0.4 -6.16 -0.32 2.11e-9 Corneal astigmatism; LUSC cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg06636001 chr8:8085503 FLJ10661 0.57 8.58 0.43 3.5e-16 Mood instability; LUSC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg18904891 chr8:8559673 CLDN23 -0.41 -6.37 -0.33 6.23e-10 Mood instability; LUSC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg11632617 chr15:75315747 PPCDC -0.55 -7.1 -0.36 7.61e-12 Blood trace element (Zn levels); LUSC cis rs13064411 0.735 rs10511326 chr3:113216325 T/C cg18753928 chr3:113234510 CCDC52 -0.52 -7.98 -0.4 2.41e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg06544989 chr22:39130855 UNC84B 0.34 6.11 0.32 2.78e-9 Menopause (age at onset); LUSC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg23630131 chr7:65973040 NA -0.21 -5.82 -0.3 1.38e-8 Aortic root size; LUSC cis rs76878669 0.917 rs10896110 chr11:66101978 G/A cg18002602 chr11:66138449 SLC29A2 -0.38 -5.91 -0.31 8.59e-9 Educational attainment (years of education); LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg12419862 chr22:24373484 LOC391322 0.8 12.3 0.56 6.01e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 6.61 0.34 1.54e-10 Rheumatoid arthritis; LUSC cis rs7586879 0.789 rs36029941 chr2:25127801 C/T cg01884057 chr2:25150051 NA 0.42 8.82 0.43 6.24e-17 Body mass index; LUSC cis rs4808199 1.000 rs7258508 chr19:19475469 T/C cg03709012 chr19:19516395 GATAD2A 1.11 13.71 0.6 3.11e-34 Nonalcoholic fatty liver disease; LUSC cis rs9902453 0.808 rs78154346 chr17:28169493 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.2 0.45 3.86e-18 Coffee consumption (cups per day); LUSC cis rs2274273 0.870 rs10134339 chr14:55814380 T/C cg04306507 chr14:55594613 LGALS3 0.56 12.96 0.58 2.13e-31 Protein biomarker; LUSC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg21963583 chr11:68658836 MRPL21 0.56 8.7 0.43 1.48e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4363385 0.507 rs6587710 chr1:152870716 A/G cg07796016 chr1:152779584 LCE1C -0.58 -8.89 -0.44 3.88e-17 Inflammatory skin disease; LUSC cis rs17270561 0.609 rs12192077 chr6:25732794 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs977987 0.843 rs11644741 chr16:75466433 C/A cg03315344 chr16:75512273 CHST6 0.5 9.52 0.46 3.5e-19 Dupuytren's disease; LUSC cis rs1775715 0.870 rs10827001 chr10:32229734 C/T cg04359828 chr10:32216031 ARHGAP12 0.38 6.41 0.33 4.83e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg02807482 chr3:125708958 NA -0.49 -6.1 -0.32 3.01e-9 Blood pressure (smoking interaction); LUSC cis rs9660992 0.762 rs1172129 chr1:205244972 T/A cg21545522 chr1:205238299 TMCC2 0.48 9.09 0.45 9.26e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs77633900 0.614 rs2439991 chr15:76877227 A/G cg21673338 chr15:77095150 SCAPER -0.69 -6.88 -0.35 2.95e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.17 0.52 7.73e-25 Prudent dietary pattern; LUSC cis rs3008870 1.000 rs2985821 chr1:67403787 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.42 0.64 6.71e-41 Lymphocyte percentage of white cells; LUSC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg17376030 chr22:41985996 PMM1 -0.48 -6.06 -0.31 3.78e-9 Cannabis dependence symptom count; LUSC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg02187348 chr16:89574699 SPG7 0.45 7.1 0.36 7.33e-12 Multiple myeloma (IgH translocation); LUSC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg12560992 chr17:57184187 TRIM37 0.86 15.57 0.65 1.69e-41 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.45 6.23 0.32 1.38e-9 Renal function-related traits (BUN); LUSC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg21984481 chr17:79567631 NPLOC4 -0.73 -15.53 -0.65 2.62e-41 Eye color traits; LUSC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg19920283 chr7:105172520 RINT1 -0.62 -7.06 -0.36 9.44e-12 Bipolar disorder (body mass index interaction); LUSC cis rs751728 0.717 rs2281816 chr6:33772335 A/G cg25922239 chr6:33757077 LEMD2 0.44 5.87 0.31 1.07e-8 Crohn's disease; LUSC cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.05e-8 Reticulocyte fraction of red cells; LUSC cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg02527881 chr3:46936655 PTH1R 0.4 6.96 0.36 1.81e-11 Colorectal cancer; LUSC trans rs61931739 0.500 rs11053273 chr12:34547255 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs11711311 1.000 rs12636577 chr3:113497507 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.88 -0.31 1.02e-8 IgG glycosylation; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg23978390 chr7:1156363 C7orf50 0.49 7.09 0.36 8.21e-12 Longevity;Endometriosis; LUSC cis rs2404602 0.692 rs12904198 chr15:77146978 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.62 -0.38 2.72e-13 Blood metabolite levels; LUSC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg24578937 chr1:2090814 PRKCZ -0.44 -9.86 -0.47 2.77e-20 Height; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.78 -0.57 1.02e-30 Platelet count; LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs7647973 1.000 rs3870339 chr3:49536863 T/A cg07636037 chr3:49044803 WDR6 0.7 9.29 0.45 2.11e-18 Menarche (age at onset); LUSC cis rs3741151 1.000 rs79078097 chr11:73049771 G/A cg17517138 chr11:73019481 ARHGEF17 1.0 8.62 0.43 2.76e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7264396 0.790 rs3746410 chr20:34190870 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -7.81 -0.39 7.72e-14 Total cholesterol levels; LUSC trans rs8073060 0.561 rs225260 chr17:33958422 T/C cg19694781 chr19:47549865 TMEM160 -1.14 -18.24 -0.71 4.68e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2836633 0.895 rs61085980 chr21:40032140 C/T cg05519781 chr21:40033154 ERG 0.77 13.3 0.59 1.09e-32 Coronary artery disease; LUSC cis rs981844 0.890 rs55850399 chr4:154684906 C/T cg14289246 chr4:154710475 SFRP2 0.55 7.04 0.36 1.12e-11 Response to statins (LDL cholesterol change); LUSC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg19230755 chr7:65878503 NA -0.44 -6.08 -0.32 3.29e-9 Aortic root size; LUSC cis rs7799006 0.606 rs12669625 chr7:2315950 C/T cg08027265 chr7:2291960 NA -0.61 -10.86 -0.51 1e-23 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs73198271 0.565 rs575895 chr8:8594247 G/A cg01851573 chr8:8652454 MFHAS1 0.41 6.28 0.33 1.04e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9811920 0.898 rs7636776 chr3:99840446 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.35 6.63 0.34 1.35e-10 Axial length; LUSC cis rs7568458 0.684 rs1048740 chr2:85764966 A/T cg02493740 chr2:85810744 VAMP5 -0.53 -9.28 -0.45 2.2e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg06481639 chr22:41940642 POLR3H 0.48 5.76 0.3 1.93e-8 Vitiligo; LUSC cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 8.8e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs1801251 1.000 rs2305137 chr2:233712049 G/A cg25237894 chr2:233734115 C2orf82 -0.35 -6.55 -0.34 2.15e-10 Coronary artery disease; LUSC cis rs11190604 1.000 rs11190569 chr10:102227409 C/T cg07080220 chr10:102295463 HIF1AN 0.62 8.46 0.42 8.57e-16 Palmitoleic acid (16:1n-7) levels; LUSC trans rs9467603 1.000 rs9467607 chr6:25809477 G/A cg06606381 chr12:133084897 FBRSL1 -0.61 -5.95 -0.31 6.75e-9 Intelligence (multi-trait analysis); LUSC trans rs6502050 0.871 rs62079994 chr17:80076516 T/C cg07393940 chr7:158741817 NA -0.37 -6.55 -0.34 2.19e-10 Life satisfaction; LUSC trans rs853679 0.607 rs33932084 chr6:28268824 A/G cg09904177 chr6:26538194 HMGN4 -0.74 -6.12 -0.32 2.61e-9 Depression; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10835308 chr12:68726120 MDM1 0.69 6.05 0.31 3.94e-9 Cognitive performance; LUSC cis rs921968 0.643 rs522377 chr2:219437476 T/C cg02176678 chr2:219576539 TTLL4 0.61 11.03 0.52 2.41e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11997175 0.574 rs4733453 chr8:33650745 A/G ch.8.33884649F chr8:33765107 NA 0.51 8.16 0.41 6.83e-15 Body mass index; LUSC cis rs12760731 0.720 rs7537811 chr1:178276421 A/T cg00404053 chr1:178313656 RASAL2 0.57 6.5 0.33 2.97e-10 Obesity-related traits; LUSC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.52 -0.34 2.59e-10 Schizophrenia; LUSC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC trans rs11098499 0.863 rs12502389 chr4:120454191 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.67 0.39 1.87e-13 Corneal astigmatism; LUSC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21515243 chr18:21033072 RIOK3 0.44 6.53 0.34 2.51e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03576123 chr11:487126 PTDSS2 -0.93 -10.38 -0.49 4.61e-22 Body mass index; LUSC cis rs17125944 0.656 rs74825460 chr14:53390015 C/T cg00686598 chr14:53173677 PSMC6 0.87 6.77 0.35 5.66e-11 Alzheimer's disease (late onset); LUSC cis rs6500395 1.000 rs28577888 chr16:48673281 T/G cg04672837 chr16:48644449 N4BP1 0.45 6.84 0.35 3.75e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.45 0.86 2.28e-98 Chronic sinus infection; LUSC cis rs2439831 0.850 rs3759790 chr15:44121030 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.65 0.34 1.17e-10 Lung cancer in ever smokers; LUSC cis rs1577917 1.000 rs12216203 chr6:86675301 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.61 -0.43 2.96e-16 Response to antipsychotic treatment; LUSC cis rs11122272 0.670 rs2474632 chr1:231484361 C/T cg06096015 chr1:231504339 EGLN1 0.56 9.88 0.48 2.29e-20 Hemoglobin concentration; LUSC cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg27446573 chr6:127587934 RNF146 0.91 15.15 0.64 7.89e-40 Breast cancer; LUSC cis rs7945705 0.875 rs11042059 chr11:8795080 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.33 6.55 0.34 2.18e-10 Hemoglobin concentration; LUSC cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.36 -5.78 -0.3 1.73e-8 IgG glycosylation; LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg08219700 chr8:58056026 NA 0.69 8.2 0.41 5.2e-15 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs77493600 chr4:97980332 A/G cg16405019 chr1:18959625 PAX7 -0.63 -6.58 -0.34 1.77e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs701145 0.938 rs355752 chr3:153970796 A/G cg17054900 chr3:154042577 DHX36 0.85 9.0 0.44 1.75e-17 Coronary artery disease; LUSC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg11764359 chr7:65958608 NA -0.7 -10.9 -0.51 6.9e-24 Aortic root size; LUSC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg09796270 chr17:17721594 SREBF1 0.36 6.08 0.32 3.26e-9 Total body bone mineral density; LUSC cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.47 -0.5 2.33e-22 Glomerular filtration rate (creatinine); LUSC cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg18225595 chr11:63971243 STIP1 0.43 6.95 0.36 1.98e-11 Platelet count; LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg04267008 chr7:1944627 MAD1L1 -0.55 -8.36 -0.42 1.66e-15 Bipolar disorder and schizophrenia; LUSC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9560113 1.000 rs9560109 chr13:112180468 C/T cg14154082 chr13:112174009 NA 0.37 7.63 0.39 2.5e-13 Menarche (age at onset); LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg27170947 chr2:26402098 FAM59B -0.7 -10.61 -0.5 7.11e-23 Gut microbiome composition (summer); LUSC cis rs9646944 0.501 rs7586983 chr2:103028066 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.6 0.34 1.65e-10 Blood protein levels; LUSC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg11764359 chr7:65958608 NA 0.68 11.0 0.52 3.08e-24 Aortic root size; LUSC cis rs2455601 0.679 rs2653559 chr11:8900394 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.42 -6.91 -0.35 2.42e-11 Schizophrenia; LUSC cis rs5758659 1.000 rs5758677 chr22:42643039 A/C cg04733989 chr22:42467013 NAGA 0.4 6.44 0.33 4.04e-10 Cognitive function; LUSC cis rs72781680 0.948 rs72796319 chr2:24133027 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs644799 0.544 rs525087 chr11:95632266 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.61 8.86 0.44 4.94e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs13253111 0.624 rs7832318 chr8:28110414 A/G cg26534493 chr8:28060551 NA 0.38 6.94 0.36 2.03e-11 Childhood body mass index; LUSC cis rs1348850 0.958 rs10930799 chr2:178459325 G/C cg22681709 chr2:178499509 PDE11A -0.46 -8.38 -0.42 1.5e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg12311346 chr5:56204834 C5orf35 -1.01 -14.59 -0.62 1.22e-37 Initial pursuit acceleration; LUSC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg24578937 chr1:2090814 PRKCZ -0.45 -10.42 -0.5 3.3e-22 Height; LUSC cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg13256891 chr4:100009986 ADH5 -0.45 -6.18 -0.32 1.85e-9 Alcohol dependence; LUSC cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC trans rs7726558 0.642 rs56309111 chr5:118883824 G/A cg14402224 chr7:50570049 DDC -0.48 -5.99 -0.31 5.34e-9 QT interval (sulfonylurea treatment interaction); LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.93 0.44 2.83e-17 Prudent dietary pattern; LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg00149659 chr3:10157352 C3orf10 -0.96 -14.06 -0.61 1.33e-35 Alzheimer's disease; LUSC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs6005807 0.719 rs28818228 chr22:29042025 G/A cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs10782582 0.586 rs5745383 chr1:76288590 G/C cg03433033 chr1:76189801 ACADM -0.43 -6.39 -0.33 5.51e-10 Daytime sleep phenotypes; LUSC trans rs7615952 0.599 rs12485717 chr3:125707075 C/T cg07211511 chr3:129823064 LOC729375 0.76 9.91 0.48 1.78e-20 Blood pressure (smoking interaction); LUSC trans rs979233 0.502 rs276270 chr5:42074932 T/G cg07010552 chr17:7358735 CHRNB1 -0.42 -6.12 -0.32 2.61e-9 Systemic lupus erythematosus; LUSC cis rs6754311 0.773 rs309179 chr2:136613780 G/A cg07169764 chr2:136633963 MCM6 -0.6 -8.05 -0.4 1.47e-14 Mosquito bite size; LUSC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg12826209 chr6:26865740 GUSBL1 0.73 9.34 0.45 1.45e-18 Intelligence (multi-trait analysis); LUSC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg16235748 chr6:149772707 ZC3H12D 0.29 5.83 0.3 1.34e-8 Dupuytren's disease; LUSC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg12463550 chr7:65579703 CRCP -0.48 -7.1 -0.36 7.51e-12 Aortic root size; LUSC cis rs1403694 0.695 rs10439971 chr3:186434188 C/T cg12454167 chr3:186435060 KNG1 0.34 8.38 0.42 1.49e-15 Blood protein levels; LUSC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.31 -0.33 8.62e-10 Total body bone mineral density; LUSC cis rs11190604 1.000 rs7071271 chr10:102264824 G/A cg07080220 chr10:102295463 HIF1AN 0.68 9.04 0.44 1.34e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg17264618 chr3:40429014 ENTPD3 0.27 5.71 0.3 2.49e-8 Renal cell carcinoma; LUSC cis rs12220238 1.000 rs10762582 chr10:75968316 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.25 0.37 2.96e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs6867032 1.000 rs16902321 chr5:2015148 A/G cg26168224 chr5:2018326 NA 0.82 16.35 0.67 1.42e-44 Gut microbiome composition (winter); LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs6542838 0.644 rs7590596 chr2:99467938 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.13 -0.32 2.44e-9 Fear of minor pain; LUSC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg08219700 chr8:58056026 NA 0.45 5.84 0.3 1.24e-8 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.546 rs6827131 chr4:98744810 C/G cg17366294 chr4:99064904 C4orf37 0.56 8.86 0.44 4.88e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs5770917 1.000 rs1056964 chr22:51017476 A/G cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.58 -5.73 -0.3 2.28e-8 Narcolepsy; LUSC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.34 0.33 7.46e-10 Lung cancer; LUSC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs10892173 0.904 rs10892172 chr11:117672474 C/A cg21640587 chr11:117668038 DSCAML1 0.4 6.11 0.32 2.76e-9 Myopia; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.96 -0.4 2.78e-14 Lymphocyte counts; LUSC cis rs506338 0.517 rs530252 chr11:64443465 T/C cg19131476 chr11:64387923 NRXN2 0.36 7.86 0.4 5.19e-14 Body mass index;Urate levels; LUSC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.19 -0.41 5.45e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg03264133 chr6:25882463 NA -0.4 -6.92 -0.35 2.28e-11 Height; LUSC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.27 -0.32 1.14e-9 Lung cancer; LUSC cis rs9515201 0.859 rs9521732 chr13:111033821 G/T cg05272587 chr13:111038400 COL4A2 -0.42 -7.09 -0.36 7.83e-12 White matter hyperintensity burden; LUSC cis rs2797160 1.000 rs1935772 chr6:125994708 T/C cg05901451 chr6:126070800 HEY2 -0.57 -8.75 -0.43 1.07e-16 Endometrial cancer; LUSC cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.73 0.35 7.22e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg20607798 chr8:58055168 NA 0.57 6.43 0.33 4.5e-10 Developmental language disorder (linguistic errors); LUSC cis rs2985684 0.948 rs6572592 chr14:50080871 G/A cg04989706 chr14:50066350 PPIL5 -0.45 -5.89 -0.31 9.5e-9 Carotid intima media thickness; LUSC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg13902645 chr11:5959945 NA -0.6 -8.4 -0.42 1.29e-15 DNA methylation (variation); LUSC cis rs9399135 1.000 rs35123050 chr6:135302740 G/A cg22676075 chr6:135203613 NA 0.49 7.56 0.38 3.85e-13 Red blood cell count; LUSC cis rs3825199 0.515 rs2072593 chr12:93970026 T/C cg18151635 chr12:93972918 NA -0.62 -8.89 -0.44 3.85e-17 Height; LUSC cis rs34375054 0.624 rs12826658 chr12:125680237 A/G cg06287003 chr12:125626642 AACS -0.36 -5.7 -0.3 2.6e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg24578937 chr1:2090814 PRKCZ -0.41 -8.95 -0.44 2.53e-17 Height; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg12335473 chr3:15140786 ZFYVE20 0.46 6.63 0.34 1.38e-10 Mosquito bite size; LUSC cis rs7923452 0.938 rs753173 chr10:30778738 T/C cg18806716 chr10:30721971 MAP3K8 0.59 6.82 0.35 4.37e-11 Itch intensity from mosquito bite; LUSC cis rs7769051 1.000 rs9493446 chr6:133125643 C/T cg07930552 chr6:133119739 C6orf192 0.79 10.32 0.49 7.22e-22 Type 2 diabetes nephropathy; LUSC cis rs2404602 0.692 rs55729975 chr15:76803226 G/A cg22467129 chr15:76604101 ETFA -0.44 -7.12 -0.36 6.84e-12 Blood metabolite levels; LUSC cis rs1577917 0.917 rs35738006 chr6:86646309 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs17270561 0.609 rs4711095 chr6:25726774 A/C cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC cis rs9325144 0.647 rs61930266 chr12:38922048 A/G cg13010199 chr12:38710504 ALG10B -0.5 -7.54 -0.38 4.42e-13 Morning vs. evening chronotype; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg14337668 chr9:99883682 NA -0.75 -6.86 -0.35 3.45e-11 Myocardial infarction; LUSC cis rs10911232 0.560 rs6697320 chr1:183037377 T/G ch.1.3577855R chr1:183094577 LAMC1 0.71 11.02 0.52 2.78e-24 Hypertriglyceridemia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00590991 chr5:176900010 DBN1 -0.48 -7.41 -0.38 1.04e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7824557 0.872 rs2572417 chr8:11111462 A/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.82 -0.43 6.69e-17 Retinal vascular caliber; LUSC cis rs1595825 0.891 rs16826791 chr2:198895133 C/G cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs9925964 0.967 rs749767 chr16:31124407 C/T cg02466173 chr16:30829666 NA -0.32 -5.89 -0.31 9.6e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs427394 0.659 rs274725 chr5:6717408 C/G cg10857441 chr5:6722123 POLS -0.45 -8.34 -0.42 1.93e-15 Menopause (age at onset); LUSC cis rs6542838 0.611 rs7588441 chr2:99518858 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.94 -0.31 7.24e-9 Fear of minor pain; LUSC trans rs12439619 0.921 rs56042848 chr15:82527585 A/T cg04831495 chr15:85060580 GOLGA6L5 -0.54 -8.2 -0.41 5.18e-15 Intelligence (multi-trait analysis); LUSC cis rs950776 0.518 rs8053 chr15:78841220 T/C cg06917634 chr15:78832804 PSMA4 -0.81 -14.26 -0.62 2.34e-36 Sudden cardiac arrest; LUSC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.61 0.5 7.35e-23 Monocyte percentage of white cells; LUSC cis rs11098499 0.954 rs10518328 chr4:120401779 G/A cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.57e-25 Corneal astigmatism; LUSC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg23887609 chr12:130822674 PIWIL1 0.49 7.36 0.37 1.48e-12 Menopause (age at onset); LUSC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg09021430 chr5:549028 NA -0.55 -7.25 -0.37 2.95e-12 Lung disease severity in cystic fibrosis; LUSC cis rs7074356 0.915 rs1870146 chr10:82210379 A/G cg00277334 chr10:82204260 NA -0.65 -6.41 -0.33 5.1e-10 Borderline personality disorder; LUSC cis rs7727544 0.582 rs10478998 chr5:131516531 G/A cg14196790 chr5:131705035 SLC22A5 0.46 7.7 0.39 1.54e-13 Blood metabolite levels; LUSC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg24110177 chr3:50126178 RBM5 0.55 9.12 0.45 7.29e-18 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 6.24 0.32 1.35e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs977987 0.843 rs62062568 chr16:75445324 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.06 -0.36 9.44e-12 Dupuytren's disease; LUSC cis rs2798269 0.902 rs2798280 chr13:22112853 T/C cg18095732 chr13:22033692 ZDHHC20 -0.41 -6.31 -0.33 8.81e-10 PR segment; LUSC cis rs12137294 0.866 rs1172151 chr1:205221659 A/C cg21643547 chr1:205240462 TMCC2 -0.33 -5.98 -0.31 5.7e-9 Red cell distribution width; LUSC cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg23711669 chr6:146136114 FBXO30 0.88 16.26 0.66 3.3e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.48 -0.33 3.34e-10 Lung cancer; LUSC trans rs10486158 0.843 rs1294616 chr7:7391479 A/C cg01895333 chr3:109035405 DPPA2 -0.38 -6.03 -0.31 4.33e-9 Bipolar disorder and schizophrenia; LUSC trans rs35110281 0.632 rs9306160 chr21:45107562 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.86 0.51 9.96e-24 Mean corpuscular volume; LUSC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg24209194 chr3:40518798 ZNF619 0.42 5.68 0.3 2.95e-8 Renal cell carcinoma; LUSC cis rs2667011 0.653 rs2666998 chr2:160844633 A/T cg06573604 chr2:160760825 LY75 -0.49 -6.2 -0.32 1.68e-9 Bilirubin levels; LUSC cis rs4595586 0.545 rs1303887 chr12:39366523 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.99 0.31 5.39e-9 Morning vs. evening chronotype; LUSC cis rs9303401 0.659 rs12946852 chr17:57013337 G/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.09 0.45 8.81e-18 Cognitive test performance; LUSC cis rs9807989 0.524 rs7594402 chr2:103021267 A/T cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17829816 chr10:102802857 NA -0.41 -6.08 -0.32 3.23e-9 Electrocardiographic conduction measures; LUSC trans rs6851442 0.614 rs28374811 chr4:109038758 G/A cg22866579 chr4:146743096 ZNF827 0.65 6.34 0.33 7.61e-10 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.71 -0.34 8.22e-11 Alzheimer's disease (late onset); LUSC cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg06092702 chr1:163392909 NA -0.42 -7.26 -0.37 2.74e-12 Motion sickness; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.61 0.43 3.03e-16 Prudent dietary pattern; LUSC cis rs10840133 1 rs10840133 chr11:8846369 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.47 8.78 0.43 8.35e-17 Reticulocyte fraction of red cells; LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.45 0.65 5.38e-41 Platelet count; LUSC trans rs3733585 0.699 rs6449202 chr4:9974043 T/C cg26043149 chr18:55253948 FECH -0.46 -6.99 -0.36 1.52e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12586317 0.620 rs17103042 chr14:35575428 T/C cg16230307 chr14:35515116 FAM177A1 0.77 10.09 0.48 4.44e-21 Psoriasis; LUSC cis rs10465746 0.725 rs6694752 chr1:84389960 C/T cg10977910 chr1:84465055 TTLL7 0.51 7.3 0.37 2.17e-12 Obesity-related traits; LUSC cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.49 0.5 1.89e-22 Schizophrenia; LUSC cis rs6750795 0.746 rs2916579 chr2:232421159 A/G cg19187155 chr2:232395269 NMUR1 0.96 19.06 0.72 2.52e-55 Height; LUSC cis rs796364 0.951 rs11897245 chr2:201063644 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.45 5.65 0.3 3.51e-8 Schizophrenia; LUSC trans rs11992162 0.551 rs35010200 chr8:11785655 G/A cg08975724 chr8:8085496 FLJ10661 -0.45 -6.4 -0.33 5.32e-10 Monocyte count; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.83 0.35 3.99e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.53 8.02 0.4 1.76e-14 Schizophrenia; LUSC cis rs782590 0.935 rs782652 chr2:55862775 C/A cg03859395 chr2:55845619 SMEK2 0.87 16.12 0.66 1.19e-43 Metabolic syndrome; LUSC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg03452623 chr4:187889614 NA -0.85 -17.18 -0.69 7.21e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg11062466 chr8:58055876 NA 0.68 7.85 0.39 5.73e-14 Developmental language disorder (linguistic errors); LUSC cis rs7568458 0.709 rs762684 chr2:85782023 G/A cg17127132 chr2:85788382 GGCX 0.43 6.23 0.32 1.39e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs17125944 0.505 rs75838476 chr14:53242362 G/A cg00686598 chr14:53173677 PSMC6 1.15 10.47 0.5 2.35e-22 Alzheimer's disease (late onset); LUSC cis rs1395 0.744 rs7600932 chr2:27474869 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.47 7.43 0.38 9.07e-13 Blood metabolite levels; LUSC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg16850897 chr7:100343110 ZAN -0.6 -8.33 -0.41 2.18e-15 Other erythrocyte phenotypes; LUSC cis rs3820928 0.935 rs113195824 chr2:227769139 A/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.99 -0.4 2.26e-14 Pulmonary function; LUSC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg16624210 chr5:671434 TPPP 0.5 6.17 0.32 1.96e-9 Lung disease severity in cystic fibrosis; LUSC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg23649088 chr2:200775458 C2orf69 0.52 7.07 0.36 9.17e-12 Schizophrenia; LUSC cis rs798554 0.671 rs1182195 chr7:2868730 A/G cg19717773 chr7:2847554 GNA12 -0.34 -5.8 -0.3 1.55e-8 Height; LUSC cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg13699009 chr12:122356056 WDR66 0.48 7.58 0.38 3.54e-13 Mean corpuscular volume; LUSC cis rs7605827 0.930 rs6733519 chr2:15525567 T/C cg19274914 chr2:15703543 NA 0.47 9.24 0.45 2.95e-18 Educational attainment (years of education); LUSC cis rs2274273 0.516 rs2149482 chr14:55368627 C/T cg04306507 chr14:55594613 LGALS3 0.31 5.9 0.31 8.84e-9 Protein biomarker; LUSC cis rs2324229 0.797 rs1180236 chr6:83944147 T/G cg08257003 chr6:84140564 ME1 0.27 6.23 0.32 1.37e-9 Platelet-derived growth factor BB levels; LUSC cis rs11153306 0.677 rs3777921 chr6:111924410 C/T cg22127309 chr6:111907043 TRAF3IP2 0.31 5.89 0.31 9.19e-9 Tonsillectomy; LUSC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.81 -0.39 7.54e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.54 0.34 2.33e-10 Menopause (age at onset); LUSC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.54 -0.34 2.35e-10 High light scatter reticulocyte count; LUSC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg02034447 chr16:89574710 SPG7 -0.39 -5.78 -0.3 1.68e-8 Multiple myeloma (IgH translocation); LUSC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg00149659 chr3:10157352 C3orf10 0.61 8.75 0.43 1.07e-16 Alzheimer's disease; LUSC cis rs11608355 0.521 rs7976839 chr12:109830534 C/A cg19025524 chr12:109796872 NA -0.4 -7.5 -0.38 6e-13 Neuroticism; LUSC cis rs1371867 0.846 rs1788189 chr8:101249762 G/T cg00191853 chr8:101177733 SPAG1 0.36 5.93 0.31 7.61e-9 Atrioventricular conduction; LUSC cis rs708547 0.599 rs2948348 chr4:57848772 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.54 8.12 0.41 8.79e-15 Response to bleomycin (chromatid breaks); LUSC cis rs250677 0.652 rs36045 chr5:148441184 A/G cg23229984 chr5:148520753 ABLIM3 -0.44 -6.35 -0.33 7.11e-10 Breast cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23612142 chr6:158589101 GTF2H5;SERAC1 -0.41 -5.96 -0.31 6.26e-9 Triglycerides; LUSC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg14703610 chr5:56206110 C5orf35 0.4 5.74 0.3 2.13e-8 Coronary artery disease; LUSC trans rs561341 0.609 rs7214626 chr17:30190989 G/A cg20587970 chr11:113659929 NA 0.81 9.8 0.47 4.41e-20 Hip circumference adjusted for BMI; LUSC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.9 0.78 1.85e-70 Height; LUSC cis rs6692729 0.933 rs1295641 chr1:227070695 C/T cg10327440 chr1:227177885 CDC42BPA -0.51 -7.32 -0.37 1.91e-12 Electrodermal activity; LUSC cis rs7246967 0.611 rs66866654 chr19:22813739 A/G cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs10203711 1.000 rs907103 chr2:239564541 A/G cg14580085 chr2:239553406 NA 0.43 7.46 0.38 7.41e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.693 rs608509 chr1:153034650 G/C cg00922841 chr1:152955080 SPRR1A -0.42 -7.28 -0.37 2.39e-12 Inflammatory skin disease; LUSC cis rs7267979 1.000 rs910997 chr20:25267301 G/A cg08601574 chr20:25228251 PYGB 0.43 6.6 0.34 1.59e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11785693 0.862 rs17435612 chr8:4987896 C/T cg26367366 chr8:4980734 NA -0.73 -8.63 -0.43 2.6e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg05043794 chr9:111880884 C9orf5 -0.33 -7.11 -0.36 7.27e-12 Menarche (age at onset); LUSC cis rs116988415 0.584 rs2269307 chr14:65245007 G/A cg25083366 chr14:65239357 SPTB 0.6 6.16 0.32 2.11e-9 Daytime sleep phenotypes; LUSC cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg24060327 chr5:131705240 SLC22A5 0.45 6.75 0.35 6.71e-11 Blood metabolite levels; LUSC cis rs1801251 1.000 rs11679079 chr2:233612656 C/T cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.34 2.87e-10 Coronary artery disease; LUSC cis rs79387448 0.810 rs76229479 chr2:103123912 A/C cg09003973 chr2:102972529 NA 0.91 8.67 0.43 1.95e-16 Gut microbiota (bacterial taxa); LUSC cis rs6964587 0.867 rs12704637 chr7:91874686 C/T cg17063962 chr7:91808500 NA 0.56 8.33 0.41 2.15e-15 Breast cancer; LUSC cis rs9952991 0.941 rs2847278 chr18:12778715 C/T cg23598886 chr18:12777645 NA 0.65 6.6 0.34 1.61e-10 Inflammatory skin disease; LUSC cis rs77633900 0.614 rs2439982 chr15:76925071 T/G cg21673338 chr15:77095150 SCAPER -0.74 -7.31 -0.37 1.99e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.71 0.7 5.89e-50 Chronic sinus infection; LUSC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg05043794 chr9:111880884 C9orf5 -0.37 -7.91 -0.4 3.86e-14 Menarche (age at onset); LUSC cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.53 8.1 0.41 1.04e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7944584 0.563 rs2280231 chr11:47600438 C/T cg20307385 chr11:47447363 PSMC3 0.86 12.46 0.56 1.57e-29 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg02807482 chr3:125708958 NA -0.48 -6.07 -0.32 3.42e-9 Blood pressure (smoking interaction); LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg07677032 chr17:61819896 STRADA 0.54 9.06 0.44 1.15e-17 Prudent dietary pattern; LUSC cis rs7264396 0.790 rs6060562 chr20:34282053 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.31 -0.45 1.73e-18 Total cholesterol levels; LUSC cis rs2354432 0.607 rs4314933 chr1:146821386 T/C cg25205988 chr1:146714368 CHD1L 0.93 8.91 0.44 3.48e-17 Mitochondrial DNA levels; LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg11843238 chr5:131593191 PDLIM4 0.41 6.92 0.35 2.33e-11 Breast cancer; LUSC cis rs13040088 0.580 rs11905041 chr20:61563408 C/T cg23096297 chr20:61557774 DIDO1 0.73 10.07 0.48 5.26e-21 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04621676 chr1:9599380 SLC25A33 0.52 8.14 0.41 8.03e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg12011299 chr4:100065546 ADH4 0.69 10.39 0.49 4.29e-22 Alcohol dependence; LUSC trans rs7615952 0.599 rs6766327 chr3:125723677 C/G cg07211511 chr3:129823064 LOC729375 -0.8 -10.52 -0.5 1.46e-22 Blood pressure (smoking interaction); LUSC cis rs62103177 0.564 rs7228971 chr18:77738025 C/T cg20368463 chr18:77673604 PQLC1 -0.67 -6.98 -0.36 1.64e-11 Opioid sensitivity; LUSC cis rs2652834 0.696 rs34317102 chr15:63414083 A/C cg05507819 chr15:63340323 TPM1 0.46 5.93 0.31 7.53e-9 HDL cholesterol; LUSC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.79 -0.3 1.63e-8 Tonsillectomy; LUSC cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 0.35 6.14 0.32 2.29e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg23711669 chr6:146136114 FBXO30 0.88 16.22 0.66 4.99e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs6083 0.549 rs11858020 chr15:58852422 A/T cg05156742 chr15:59063176 FAM63B 0.4 6.1 0.32 2.94e-9 Schizophrenia; LUSC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg01097406 chr16:89675127 NA 0.48 10.13 0.48 3.25e-21 Vitiligo; LUSC cis rs9427116 0.502 rs9426830 chr1:154594690 A/G cg17218026 chr1:154582156 ADAR 0.59 10.55 0.5 1.24e-22 Blood protein levels; LUSC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.92 0.4 3.47e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11958404 0.932 rs72816572 chr5:157429818 T/C cg05962755 chr5:157440814 NA 0.54 6.34 0.33 7.29e-10 IgG glycosylation; LUSC cis rs6951245 0.678 rs4724725 chr7:1214751 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.48 -6.25 -0.32 1.29e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg15556689 chr8:8085844 FLJ10661 -0.54 -7.74 -0.39 1.2e-13 Triglycerides; LUSC cis rs500891 0.525 rs1361784 chr6:84090690 A/T cg08257003 chr6:84140564 ME1 0.35 8.5 0.42 6.18e-16 Platelet-derived growth factor BB levels; LUSC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.04 15.58 0.65 1.58e-41 Age-related macular degeneration (geographic atrophy); LUSC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg09835421 chr16:68378352 PRMT7 -0.54 -6.05 -0.31 3.98e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs71403859 0.502 rs12927006 chr16:71549911 A/G cg08717414 chr16:71523259 ZNF19 -0.72 -8.46 -0.42 8.21e-16 Post bronchodilator FEV1; LUSC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg15744005 chr10:104629667 AS3MT -0.29 -6.25 -0.32 1.27e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7264396 0.836 rs6058276 chr20:34187728 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -7.76 -0.39 1.02e-13 Total cholesterol levels; LUSC cis rs6547741 1.000 rs6706610 chr2:27778091 G/A cg27432699 chr2:27873401 GPN1 0.8 15.01 0.63 2.67e-39 Oral cavity cancer; LUSC cis rs2486288 0.656 rs2413773 chr15:45549442 C/A cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.7 -0.51 3.49e-23 Glomerular filtration rate; LUSC cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg02527881 chr3:46936655 PTH1R -0.37 -6.59 -0.34 1.67e-10 Colorectal cancer; LUSC cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg00268967 chr12:58002603 GEFT;DTX3 -0.37 -5.86 -0.31 1.14e-8 Celiac disease or Rheumatoid arthritis; LUSC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.83 -10.92 -0.51 6.32e-24 Schizophrenia; LUSC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg22875332 chr1:76189707 ACADM -0.84 -14.92 -0.63 6.12e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg10609677 chr17:41278573 BRCA1;NBR2 0.36 5.86 0.31 1.09e-8 Menopause (age at onset); LUSC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg24578937 chr1:2090814 PRKCZ 0.46 10.09 0.48 4.45e-21 Height; LUSC cis rs1190596 0.525 rs7152627 chr14:102698399 C/T cg18135206 chr14:102964638 TECPR2 -0.51 -6.2 -0.32 1.62e-9 Behavioural disinhibition (generation interaction); LUSC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg26597838 chr10:835615 NA 1.02 14.32 0.62 1.37e-36 Eosinophil percentage of granulocytes; LUSC cis rs11098499 0.863 rs6833334 chr4:120504227 C/T cg24375607 chr4:120327624 NA 0.75 11.3 0.53 2.65e-25 Corneal astigmatism; LUSC cis rs2835872 0.965 rs2835852 chr21:39014128 A/G cg20424643 chr21:39039972 KCNJ6 -0.42 -6.54 -0.34 2.26e-10 Electroencephalographic traits in alcoholism; LUSC cis rs3820928 0.874 rs4461255 chr2:227846524 C/T cg11843606 chr2:227700838 RHBDD1 0.54 7.92 0.4 3.58e-14 Pulmonary function; LUSC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg06108461 chr20:60628389 TAF4 -0.97 -16.59 -0.67 1.62e-45 Body mass index; LUSC cis rs9467773 0.529 rs7356988 chr6:26396727 G/T cg05738196 chr6:26577821 NA -0.46 -6.56 -0.34 2.02e-10 Intelligence (multi-trait analysis); LUSC cis rs1348850 0.872 rs4893959 chr2:178400204 G/A cg22681709 chr2:178499509 PDE11A -0.49 -9.09 -0.45 8.97e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg06634786 chr22:41940651 POLR3H -0.6 -6.81 -0.35 4.48e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7312933 0.645 rs11181404 chr12:42683840 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.81 0.35 4.44e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg16584290 chr5:462447 EXOC3 -0.38 -6.62 -0.34 1.43e-10 Cystic fibrosis severity; LUSC cis rs4704187 0.687 rs1345704 chr5:74489998 G/A cg03227963 chr5:74354835 NA 0.31 6.72 0.35 7.65e-11 Response to amphetamines; LUSC cis rs7615952 0.736 rs9862893 chr3:125686974 A/G cg02807482 chr3:125708958 NA -0.54 -6.06 -0.31 3.65e-9 Blood pressure (smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18082322 chr5:148725041 GRPEL2 -0.4 -6.1 -0.32 3e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4646450 0.636 rs6955490 chr7:98974588 C/T cg24650262 chr7:98904301 NA 0.55 6.25 0.32 1.26e-9 Blood metabolite levels; LUSC cis rs6460942 0.908 rs73677559 chr7:12270819 A/C cg06484146 chr7:12443880 VWDE -0.55 -6.02 -0.31 4.54e-9 Coronary artery disease; LUSC cis rs9807841 0.670 rs2569512 chr19:10790162 A/G cg09936142 chr19:10668400 KRI1 -0.44 -7.02 -0.36 1.22e-11 Inflammatory skin disease; LUSC cis rs7246657 0.943 rs7246993 chr19:37890154 C/T cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg11062466 chr8:58055876 NA 0.5 6.57 0.34 1.89e-10 Developmental language disorder (linguistic errors); LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T cg15463457 chr4:90823130 MMRN1 -0.38 -5.98 -0.31 5.88e-9 Leprosy; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg16405210 chr4:1374714 KIAA1530 0.53 8.07 0.4 1.32e-14 Obesity-related traits; LUSC cis rs2242663 0.798 rs1791679 chr11:66337874 C/A cg18002602 chr11:66138449 SLC29A2 -0.35 -6.21 -0.32 1.56e-9 Bipolar disorder; LUSC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg24977027 chr2:88469347 THNSL2 0.56 5.84 0.3 1.21e-8 Plasma clusterin levels; LUSC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg27165867 chr14:105738592 BRF1 -0.52 -7.75 -0.39 1.13e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs7605827 0.930 rs7605727 chr2:15598693 A/G cg19274914 chr2:15703543 NA 0.46 8.79 0.43 8.29e-17 Educational attainment (years of education); LUSC cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg23158103 chr7:148848205 ZNF398 -0.5 -8.45 -0.42 9.1e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg23630131 chr7:65973040 NA -0.22 -6.17 -0.32 2e-9 Aortic root size; LUSC cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg06784218 chr1:46089804 CCDC17 0.36 6.12 0.32 2.67e-9 Platelet count; LUSC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg06697600 chr4:7070879 GRPEL1 -0.4 -6.61 -0.34 1.49e-10 Monocyte percentage of white cells; LUSC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg22437258 chr11:111473054 SIK2 -0.44 -5.87 -0.31 1.08e-8 Primary sclerosing cholangitis; LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg03465714 chr1:152285911 FLG -0.36 -6.43 -0.33 4.48e-10 Inflammatory skin disease; LUSC cis rs7927592 0.513 rs901823 chr11:68205578 T/C cg16797656 chr11:68205561 LRP5 0.49 8.82 0.43 6.53e-17 Total body bone mineral density; LUSC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 7.89 0.4 4.22e-14 Melanoma; LUSC cis rs3741151 0.686 rs7114009 chr11:73115314 C/T cg17517138 chr11:73019481 ARHGEF17 -0.85 -8.15 -0.41 7.26e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1178968 1.000 rs1178968 chr7:72767451 T/C cg25889504 chr7:72793014 NA 0.6 7.76 0.39 1.02e-13 Triglyceride levels; LUSC cis rs7264396 0.709 rs2425073 chr20:34293699 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.44 -0.46 6.59e-19 Total cholesterol levels; LUSC trans rs11992162 0.636 rs4841646 chr8:11798707 C/G cg27411982 chr8:10470053 RP1L1 0.42 6.33 0.33 7.72e-10 Monocyte count; LUSC cis rs7640424 0.929 rs17828045 chr3:107821546 A/C cg09227934 chr3:107805635 CD47 -0.45 -7.24 -0.37 3.17e-12 Body mass index; LUSC cis rs9398803 0.865 rs9388495 chr6:126782457 G/A cg19875578 chr6:126661172 C6orf173 0.41 5.93 0.31 7.72e-9 Male-pattern baldness; LUSC trans rs9467603 0.925 rs28412066 chr6:25775570 T/A cg06606381 chr12:133084897 FBRSL1 0.59 5.95 0.31 6.9e-9 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg23711669 chr6:146136114 FBXO30 0.9 17.03 0.68 2.99e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg04450456 chr4:17643702 FAM184B 0.39 6.56 0.34 2.06e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10744422 1.000 rs7959441 chr12:123363825 C/T cg25930673 chr12:123319894 HIP1R -0.63 -6.2 -0.32 1.66e-9 Schizophrenia; LUSC cis rs9814567 0.752 rs9846111 chr3:134335034 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.51 -0.56 1.02e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.66 10.14 0.49 3.13e-21 Lymphocyte counts; LUSC cis rs3849570 1.000 rs9817181 chr3:81827765 A/C cg07356753 chr3:81810745 GBE1 -0.68 -11.09 -0.52 1.46e-24 Waist circumference;Body mass index; LUSC trans rs7939886 0.920 rs7940563 chr11:55875133 C/T cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg04369109 chr6:150039330 LATS1 -0.6 -8.85 -0.44 5.18e-17 Lung cancer; LUSC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg19077165 chr18:44547161 KATNAL2 -0.41 -5.89 -0.31 9.19e-9 Personality dimensions; LUSC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg16405210 chr4:1374714 KIAA1530 -0.52 -7.86 -0.39 5.42e-14 Obesity-related traits; LUSC cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs354225 0.544 rs10182836 chr2:54808504 T/G cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs8072100 1.000 rs8072100 chr17:45674687 A/T cg25173405 chr17:45401733 C17orf57 0.39 6.34 0.33 7.47e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg16624210 chr5:671434 TPPP 0.5 6.32 0.33 8.21e-10 Obesity-related traits; LUSC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg23172400 chr8:95962367 TP53INP1 -0.35 -6.72 -0.34 8.05e-11 Type 2 diabetes; LUSC cis rs2970818 0.831 rs11063202 chr12:4593690 A/G cg11146114 chr12:4671731 NA -0.59 -5.71 -0.3 2.44e-8 Phosphorus levels; LUSC cis rs12410462 0.681 rs113316536 chr1:227547033 T/G cg10327440 chr1:227177885 CDC42BPA -0.66 -6.47 -0.33 3.44e-10 Major depressive disorder; LUSC cis rs1448094 0.872 rs7300073 chr12:86393513 A/C cg00310523 chr12:86230176 RASSF9 0.36 6.49 0.33 3.04e-10 Major depressive disorder; LUSC cis rs3733585 0.563 rs881971 chr4:9930962 A/G cg00071950 chr4:10020882 SLC2A9 -0.48 -8.06 -0.4 1.33e-14 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs12310956 0.515 rs1830086 chr12:33958874 C/T cg26384229 chr12:38710491 ALG10B 0.75 11.76 0.54 5.77e-27 Morning vs. evening chronotype; LUSC cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.48 -0.42 7.36e-16 Body mass index; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 11.71 0.54 9.17e-27 Alzheimer's disease; LUSC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg12639453 chr1:2035780 PRKCZ -0.31 -6.54 -0.34 2.26e-10 Height; LUSC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg26752003 chr8:145688521 CYHR1 0.63 10.1 0.48 4.2e-21 Age at first birth; LUSC cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs208520 0.690 rs1351867 chr6:66760995 A/G cg07460842 chr6:66804631 NA 1.09 17.2 0.69 6.12e-48 Exhaled nitric oxide output; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03190379 chr12:49690636 PRPH 0.43 6.21 0.32 1.62e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs977987 0.735 rs166013 chr16:75434146 C/T cg03315344 chr16:75512273 CHST6 -0.53 -9.41 -0.46 8.15e-19 Dupuytren's disease; LUSC cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg04586622 chr2:25135609 ADCY3 0.4 8.34 0.42 1.98e-15 Body mass index; LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.68 0.47 1.09e-19 Bipolar disorder; LUSC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg05425664 chr17:57184151 TRIM37 0.55 8.04 0.4 1.55e-14 Intelligence (multi-trait analysis); LUSC cis rs377070 0.717 rs6534359 chr4:123596694 A/T cg10495464 chr4:123653540 BBS12;LOC729338 -0.43 -6.36 -0.33 6.48e-10 Mosquito bite size; LUSC cis rs12701220 0.762 rs7777565 chr7:1003011 C/A cg26769984 chr7:1090371 C7orf50 0.45 6.39 0.33 5.52e-10 Bronchopulmonary dysplasia; LUSC cis rs7786808 0.544 rs6971888 chr7:158193835 G/A cg01191920 chr7:158217561 PTPRN2 0.46 9.3 0.45 1.84e-18 Obesity-related traits; LUSC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg21016266 chr12:122356598 WDR66 0.61 9.11 0.45 7.83e-18 Mean corpuscular volume; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg10862848 chr6:42927986 GNMT -0.28 -6.56 -0.34 2.01e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs834811 0.831 rs1097147 chr7:135880446 C/T cg01726295 chr7:135938950 NA 0.39 6.83 0.35 3.95e-11 Post-traumatic stress disorder; LUSC cis rs4566357 0.521 rs78411533 chr2:227910807 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.3 -0.41 2.67e-15 Coronary artery disease; LUSC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg21782813 chr7:2030301 MAD1L1 -0.52 -9.11 -0.45 7.87e-18 Bipolar disorder and schizophrenia; LUSC cis rs1153858 1.000 rs4775895 chr15:45617957 T/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.03 0.4 1.64e-14 Homoarginine levels; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC cis rs8017423 1.000 rs1959001 chr14:90667739 G/A cg04374321 chr14:90722782 PSMC1 0.68 10.67 0.5 4.48e-23 Mortality in heart failure; LUSC cis rs11625487 1.000 rs11625487 chr14:77961609 G/C cg16049707 chr14:77965284 ISM2 0.59 8.26 0.41 3.43e-15 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs2708377 0.860 rs7962445 chr12:11305844 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg00383909 chr3:49044727 WDR6 -0.44 -5.91 -0.31 8.64e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9814567 0.574 rs7650509 chr3:134170971 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.56 8.21 0.41 4.9e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.43 -0.38 9.16e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs13191362 0.507 rs2849534 chr6:163144657 T/A cg14584255 chr6:163149320 PACRG;PARK2 -0.38 -7.49 -0.38 6.17e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.39 0.56 2.97e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11190604 1.000 rs7905961 chr10:102297391 G/C cg23241863 chr10:102295624 HIF1AN 0.47 5.94 0.31 7.14e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3820068 0.608 rs7516683 chr1:16020502 A/G cg13390004 chr1:15929781 NA -0.39 -6.52 -0.34 2.64e-10 Systolic blood pressure; LUSC trans rs9929218 1.000 rs12930371 chr16:68802936 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 12.11 0.55 3.21e-28 Colorectal cancer; LUSC cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg24399712 chr22:39784796 NA -0.61 -10.28 -0.49 9.79e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs193541 0.507 rs9327274 chr5:122076870 A/C cg19077854 chr5:122220652 SNX24 -0.27 -5.99 -0.31 5.38e-9 Glucose homeostasis traits; LUSC cis rs6977660 0.714 rs10229108 chr7:19824253 G/A cg07541023 chr7:19748670 TWISTNB 0.6 6.37 0.33 6.35e-10 Thyroid stimulating hormone; LUSC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg03676636 chr4:99064102 C4orf37 0.37 8.31 0.41 2.4e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg21433313 chr16:3507492 NAT15 0.41 5.99 0.31 5.54e-9 Body mass index (adult); LUSC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg22800045 chr5:56110881 MAP3K1 0.68 9.25 0.45 2.66e-18 Initial pursuit acceleration; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg05420668 chr16:28891176 ATP2A1 0.44 6.59 0.34 1.69e-10 Eotaxin levels; LUSC cis rs1670533 1.000 rs10026482 chr4:1051128 C/G cg19318889 chr4:1322082 MAEA 0.43 5.66 0.3 3.22e-8 Recombination rate (females); LUSC cis rs34779708 0.931 rs4934700 chr10:35310842 A/G cg04310649 chr10:35416472 CREM -0.43 -6.52 -0.34 2.59e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7923609 0.902 rs10733793 chr10:65323809 T/G cg01631684 chr10:65280961 REEP3 -0.42 -6.59 -0.34 1.76e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs11677370 0.561 rs13003140 chr2:3816759 G/T cg17052675 chr2:3827356 NA -0.64 -9.49 -0.46 4.37e-19 Type 2 diabetes; LUSC cis rs6964587 0.626 rs10280301 chr7:91524258 A/T cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs6840360 1.000 rs751012 chr4:152602247 A/C cg22705602 chr4:152727874 NA -0.27 -5.71 -0.3 2.48e-8 Intelligence (multi-trait analysis); LUSC trans rs7937682 0.632 rs12785809 chr11:111776055 T/A cg18187862 chr3:45730750 SACM1L -0.55 -6.65 -0.34 1.16e-10 Primary sclerosing cholangitis; LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg19318889 chr4:1322082 MAEA 0.44 6.95 0.36 1.95e-11 Obesity-related traits; LUSC cis rs8141797 0.748 rs2051199 chr22:24465845 A/G cg00411358 chr22:24577142 SUSD2 0.62 6.19 0.32 1.76e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs77106637 0.932 rs74439784 chr11:72649396 A/T cg04827223 chr11:72435913 ARAP1 -0.65 -8.46 -0.42 8.6e-16 Type 2 diabetes; LUSC cis rs3806843 0.576 rs246006 chr5:140339228 G/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs56399783 0.614 rs73047368 chr7:2766396 G/T cg19731401 chr7:2775893 GNA12 0.73 8.79 0.43 8.04e-17 Childhood ear infection; LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.81 0.35 4.49e-11 Obesity-related traits; LUSC cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.29 -0.33 9.76e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs67072384 0.818 rs7926287 chr11:72464525 A/G cg04827223 chr11:72435913 ARAP1 -0.66 -6.51 -0.34 2.82e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg16414030 chr3:133502952 NA -0.41 -6.37 -0.33 6.09e-10 Iron status biomarkers; LUSC trans rs1325195 0.881 rs2816202 chr1:179162437 C/T cg11624085 chr17:8464688 MYH10 0.41 6.64 0.34 1.29e-10 IgE grass sensitization; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25045127 chr20:23402051 NAPB -0.4 -6.0 -0.31 5.02e-9 Electrocardiographic conduction measures; LUSC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs1595825 0.838 rs16823400 chr2:198603229 A/G cg10547527 chr2:198650123 BOLL -0.49 -5.65 -0.3 3.53e-8 Ulcerative colitis; LUSC cis rs1568889 0.838 rs716366 chr11:28121536 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.79 0.57 9.36e-31 Bipolar disorder; LUSC cis rs5758659 0.652 rs133330 chr22:42409456 G/A cg04733989 chr22:42467013 NAGA 0.39 6.62 0.34 1.45e-10 Cognitive function; LUSC cis rs4805272 0.512 rs4805278 chr19:29336664 C/T cg12756686 chr19:29218302 NA 0.56 6.28 0.33 1.03e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7246657 0.653 rs10414983 chr19:37665732 T/C cg23950597 chr19:37808831 NA -0.57 -5.79 -0.3 1.64e-8 Coronary artery calcification; LUSC cis rs9325144 0.555 rs4882358 chr12:38726640 A/G cg13010199 chr12:38710504 ALG10B 0.47 7.28 0.37 2.43e-12 Morning vs. evening chronotype; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg12419862 chr22:24373484 LOC391322 -0.84 -13.78 -0.6 1.6e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7605827 0.930 rs2111458 chr2:15598039 T/A cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.55e-18 Educational attainment (years of education); LUSC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg11663144 chr21:46675770 NA -0.38 -6.4 -0.33 5.27e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01813026 chr11:809279 RPLP2 -0.42 -6.16 -0.32 2.13e-9 Electrocardiographic conduction measures; LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 12.53 0.57 8.69e-30 Platelet count; LUSC cis rs9807841 0.670 rs10405617 chr19:10752968 C/T cg09936142 chr19:10668400 KRI1 0.42 6.64 0.34 1.27e-10 Inflammatory skin disease; LUSC cis rs2797160 1.000 rs2747722 chr6:126009629 A/G cg05901451 chr6:126070800 HEY2 0.57 8.56 0.42 4.25e-16 Endometrial cancer; LUSC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg08847533 chr14:75593920 NEK9 0.84 15.63 0.65 1.04e-41 Height; LUSC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg09703963 chr11:616879 IRF7;MUPCDH -0.46 -7.2 -0.37 4e-12 Systemic lupus erythematosus; LUSC trans rs2980439 0.818 rs2948294 chr8:8094961 A/G cg21775007 chr8:11205619 TDH 0.46 6.46 0.33 3.81e-10 Neuroticism; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.87 10.37 0.49 4.93e-22 Alzheimer's disease; LUSC cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.21 0.56 1.32e-28 Colorectal cancer; LUSC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg20503657 chr10:835505 NA 0.94 13.65 0.6 5.2e-34 Eosinophil percentage of granulocytes; LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg12564285 chr5:131593104 PDLIM4 0.47 8.66 0.43 1.98e-16 Blood metabolite levels; LUSC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.65 -0.3 3.36e-8 Life satisfaction; LUSC cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg26373071 chr5:1325741 CLPTM1L 0.41 7.54 0.38 4.61e-13 Lung cancer; LUSC trans rs10506458 0.915 rs998505 chr12:63400018 C/T cg22491629 chr6:157744540 C6orf35 -0.89 -10.89 -0.51 7.48e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg22105103 chr4:187893119 NA 0.72 13.95 0.61 3.66e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.13 -0.45 6.87e-18 Gut microbiome composition (summer); LUSC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg02807482 chr3:125708958 NA -0.5 -6.21 -0.32 1.55e-9 Blood pressure (smoking interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05477027 chr19:46295590 DMWD 0.41 6.12 0.32 2.64e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6754311 0.731 rs3754686 chr2:136603276 T/C cg25344623 chr2:136566232 LCT 0.39 5.85 0.3 1.19e-8 Mosquito bite size; LUSC cis rs9323205 0.677 rs4264315 chr14:51728356 G/A cg23942311 chr14:51606299 NA -0.4 -7.37 -0.37 1.31e-12 Cancer; LUSC cis rs10782582 0.593 rs1412717 chr1:76125471 C/T cg03433033 chr1:76189801 ACADM -0.45 -6.84 -0.35 3.86e-11 Daytime sleep phenotypes; LUSC cis rs354225 0.544 rs10184128 chr2:54803816 A/G cg01766943 chr2:54829624 SPTBN1 0.48 7.69 0.39 1.64e-13 Schizophrenia; LUSC cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.6 0.65 1.31e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.11e-16 Schizophrenia; LUSC cis rs7481584 0.669 rs12421922 chr11:3035070 A/G cg25174290 chr11:3078921 CARS -0.38 -5.69 -0.3 2.78e-8 Calcium levels; LUSC cis rs679087 1.000 rs679087 chr12:29917265 C/A cg14258853 chr12:29935411 TMTC1 -0.98 -16.21 -0.66 5.08e-44 Schizophrenia; LUSC cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg18681998 chr4:17616180 MED28 0.84 15.22 0.64 4.34e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4629710 0.545 rs3777477 chr6:131534374 T/C cg12606694 chr6:131520996 AKAP7 0.55 8.09 0.4 1.09e-14 Multiple myeloma (IgH translocation); LUSC cis rs9398803 0.865 rs4565329 chr6:126752798 A/G cg19875578 chr6:126661172 C6orf173 -0.42 -6.3 -0.33 9.61e-10 Male-pattern baldness; LUSC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg01475377 chr6:109611718 NA -0.43 -7.86 -0.4 5.3e-14 Reticulocyte fraction of red cells; LUSC cis rs965513 0.901 rs7045465 chr9:100534823 A/T cg13688889 chr9:100608707 NA -0.42 -6.49 -0.33 3.1e-10 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg06238570 chr21:40685208 BRWD1 -0.63 -10.76 -0.51 2.26e-23 Cognitive function; LUSC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg14830002 chr1:247616686 OR2B11 0.49 7.15 0.36 5.55e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg03351412 chr1:154909251 PMVK 0.53 8.06 0.4 1.4e-14 Prostate cancer; LUSC cis rs10740039 0.883 rs1837945 chr10:62393515 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4363385 0.693 rs662506 chr1:153048386 A/C cg00922841 chr1:152955080 SPRR1A 0.42 7.4 0.38 1.08e-12 Inflammatory skin disease; LUSC cis rs9611565 0.592 rs4481089 chr22:41980892 T/C cg03806693 chr22:41940476 POLR3H -0.91 -12.72 -0.57 1.7e-30 Vitiligo; LUSC cis rs4664308 0.967 rs34248629 chr2:160902497 C/T cg03641300 chr2:160917029 PLA2R1 -0.64 -10.81 -0.51 1.5e-23 Idiopathic membranous nephropathy; LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.69 -0.57 2.24e-30 Platelet count; LUSC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg00343986 chr7:65444356 GUSB 0.44 6.72 0.35 7.92e-11 Aortic root size; LUSC cis rs7605827 0.930 rs2052437 chr2:15697819 A/G cg19274914 chr2:15703543 NA 0.45 8.6 0.43 3.1e-16 Educational attainment (years of education); LUSC cis rs208520 0.770 rs2153941 chr6:66885521 A/T cg07460842 chr6:66804631 NA -1.06 -15.7 -0.65 5.45e-42 Exhaled nitric oxide output; LUSC cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg18904891 chr8:8559673 CLDN23 0.59 8.1 0.41 1.03e-14 Obesity-related traits; LUSC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg02423579 chr7:2872169 GNA12 -0.41 -6.22 -0.32 1.46e-9 Height; LUSC cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg24558204 chr6:135376177 HBS1L 0.68 10.85 0.51 1.08e-23 High light scatter reticulocyte percentage of red cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24877792 chr5:180287685 ZFP62 0.42 6.19 0.32 1.74e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4843747 0.573 rs7499959 chr16:88110422 C/G cg17633681 chr16:88106987 BANP 0.43 8.62 0.43 2.65e-16 Menopause (age at onset); LUSC cis rs72781680 0.652 rs72794281 chr2:23893265 G/A cg20701182 chr2:24300061 SF3B14 0.77 7.45 0.38 8.07e-13 Lymphocyte counts; LUSC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.29e-12 Extrinsic epigenetic age acceleration; LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.36 0.53 1.66e-25 Menopause (age at onset); LUSC cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.18 -0.45 4.78e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7824557 0.592 rs2572371 chr8:11223793 G/T cg06636001 chr8:8085503 FLJ10661 0.45 6.84 0.35 3.82e-11 Retinal vascular caliber; LUSC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg09365446 chr1:150670422 GOLPH3L 0.47 7.05 0.36 1.02e-11 Melanoma; LUSC cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg13319975 chr6:146136371 FBXO30 0.48 7.37 0.37 1.31e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7954584 0.604 rs34159444 chr12:122416667 A/G cg01765077 chr12:122356316 WDR66 0.52 7.48 0.38 6.84e-13 Mean corpuscular volume; LUSC cis rs9400467 0.528 rs7451051 chr6:111744818 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.38 -7.19 -0.37 4.39e-12 Blood metabolite levels;Amino acid levels; LUSC cis rs9467773 0.620 rs2494716 chr6:26662736 T/C cg09904177 chr6:26538194 HMGN4 0.66 11.74 0.54 7.2e-27 Intelligence (multi-trait analysis); LUSC cis rs11626933 1.000 rs3825661 chr14:90767607 C/T cg14092571 chr14:90743983 NA 0.84 17.76 0.7 3.62e-50 Gut microbiota (bacterial taxa); LUSC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg19622623 chr12:86230825 RASSF9 -0.45 -6.22 -0.32 1.53e-9 Major depressive disorder; LUSC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg15145296 chr3:125709740 NA -0.56 -6.31 -0.33 9e-10 Blood pressure (smoking interaction); LUSC cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.51 -0.46 4.02e-19 Chronic sinus infection; LUSC cis rs2742417 0.967 rs2742462 chr3:45774696 G/A cg09608765 chr3:45636137 LIMD1 -0.37 -7.38 -0.37 1.29e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs734999 0.505 rs4073285 chr1:2539796 C/T cg18932078 chr1:2524107 MMEL1 0.32 6.96 0.36 1.77e-11 Ulcerative colitis; LUSC cis rs7954584 0.813 rs12827200 chr12:122451278 G/A cg01765077 chr12:122356316 WDR66 0.47 6.67 0.34 1.05e-10 Mean corpuscular volume; LUSC cis rs8031584 0.578 rs1088473 chr15:31139298 A/G cg14829155 chr15:31115871 NA 0.72 10.7 0.51 3.74e-23 Huntington's disease progression; LUSC trans rs12210905 0.920 rs72839468 chr6:27301734 A/G cg11837749 chr1:55047332 ACOT11 0.65 6.05 0.31 3.86e-9 Hip circumference adjusted for BMI; LUSC cis rs11122272 0.668 rs2749712 chr1:231537751 T/A cg06096015 chr1:231504339 EGLN1 0.56 9.92 0.48 1.75e-20 Hemoglobin concentration; LUSC cis rs2070488 0.775 rs7649984 chr3:38570221 C/T cg24069376 chr3:38537580 EXOG -0.39 -7.56 -0.38 4.02e-13 Electrocardiographic conduction measures; LUSC cis rs6906287 0.647 rs35962656 chr6:118919593 G/T cg21191810 chr6:118973309 C6orf204 0.32 5.96 0.31 6.53e-9 Electrocardiographic conduction measures; LUSC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg14552801 chr7:65878734 NA 0.39 6.08 0.32 3.34e-9 Aortic root size; LUSC cis rs1348850 0.632 rs11678875 chr2:178509068 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.91 0.31 8.55e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6554196 0.508 rs6554200 chr4:55529409 G/C cg18836493 chr4:55524333 KIT -0.46 -7.88 -0.4 4.6e-14 Monocyte count; LUSC cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg02753203 chr1:228287806 NA -0.65 -11.12 -0.52 1.23e-24 Diastolic blood pressure; LUSC cis rs6121246 0.559 rs6058468 chr20:30406448 C/A cg13852791 chr20:30311386 BCL2L1 0.9 13.6 0.6 7.89e-34 Mean corpuscular hemoglobin; LUSC cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.19 0.59 2.89e-32 Chronic sinus infection; LUSC cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg18196295 chr10:418757 DIP2C -0.47 -7.03 -0.36 1.14e-11 Psychosis in Alzheimer's disease; LUSC cis rs11587400 0.574 rs2268696 chr1:115219083 T/A cg12756093 chr1:115239321 AMPD1 -0.42 -6.26 -0.32 1.16e-9 Autism; LUSC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.88 0.4 4.57e-14 Parkinson's disease; LUSC cis rs2280018 0.526 rs2966128 chr16:15153389 G/T cg07549590 chr16:15018862 NA -0.61 -10.29 -0.49 9.65e-22 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7107174 1.000 rs729354 chr11:77962453 T/A cg02023728 chr11:77925099 USP35 0.46 6.85 0.35 3.58e-11 Testicular germ cell tumor; LUSC cis rs4700695 0.841 rs251614 chr5:65228251 C/G cg21114390 chr5:65439923 SFRS12 -0.52 -6.17 -0.32 1.95e-9 Facial morphology (factor 19); LUSC cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg15744005 chr10:104629667 AS3MT -0.3 -5.69 -0.3 2.78e-8 Arsenic metabolism; LUSC cis rs4319547 0.697 rs7974262 chr12:122896385 C/T cg05707623 chr12:122985044 ZCCHC8 0.65 8.08 0.4 1.23e-14 Body mass index; LUSC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg18904891 chr8:8559673 CLDN23 0.56 7.84 0.39 6.25e-14 Obesity-related traits; LUSC cis rs2969070 0.867 rs2906166 chr7:2508072 A/G cg03277898 chr7:2518824 NA -0.27 -5.81 -0.3 1.49e-8 Diastolic blood pressure; LUSC cis rs11792861 0.926 rs10512391 chr9:111809530 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.49 7.14 0.36 5.78e-12 Menarche (age at onset); LUSC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.43 -8.45 -0.42 8.83e-16 Monocyte percentage of white cells; LUSC cis rs9611565 0.649 rs5758434 chr22:42116163 G/A cg17376030 chr22:41985996 PMM1 -0.42 -5.69 -0.3 2.76e-8 Vitiligo; LUSC cis rs9837602 1.000 rs6806178 chr3:99780393 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.15 0.32 2.16e-9 Breast cancer; LUSC trans rs9650657 0.801 rs718741 chr8:10614384 C/T cg15556689 chr8:8085844 FLJ10661 -0.4 -5.97 -0.31 6.19e-9 Neuroticism; LUSC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg07716408 chr11:68623521 NA -0.29 -5.77 -0.3 1.84e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg10356904 chr22:49881777 NA -0.33 -7.39 -0.37 1.21e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2637266 1.000 rs11001829 chr10:78343387 A/T cg18941641 chr10:78392320 NA 0.4 7.41 0.38 1.04e-12 Pulmonary function; LUSC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg18758796 chr5:131593413 PDLIM4 0.34 5.86 0.31 1.14e-8 Blood metabolite levels; LUSC cis rs8099014 1.000 rs9319930 chr18:56123799 C/T cg12907477 chr18:56117327 MIR122 0.43 6.81 0.35 4.67e-11 Platelet count; LUSC cis rs709400 0.663 rs9671911 chr14:103967343 T/C cg12935359 chr14:103987150 CKB -0.51 -7.74 -0.39 1.17e-13 Body mass index; LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.68 11.14 0.52 9.84e-25 Prudent dietary pattern; LUSC cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg14438399 chr17:27053147 TLCD1 0.52 5.75 0.3 2.05e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs55665837 1.000 rs34382046 chr11:14451318 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 7.25e-13 Vitamin D levels; LUSC trans rs6601327 0.641 rs7461939 chr8:9571621 C/T cg15556689 chr8:8085844 FLJ10661 -0.44 -6.08 -0.32 3.28e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs12310956 0.510 rs7965329 chr12:33868199 C/A cg13010199 chr12:38710504 ALG10B 0.45 6.9 0.35 2.69e-11 Morning vs. evening chronotype; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg11965913 chr1:205819406 PM20D1 0.6 10.45 0.5 2.57e-22 Menarche (age at onset); LUSC cis rs3820068 0.608 rs6668919 chr1:16049893 A/G cg13390004 chr1:15929781 NA -0.39 -6.47 -0.33 3.51e-10 Systolic blood pressure; LUSC cis rs7582720 1.000 rs72926791 chr2:203822891 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs5758659 0.622 rs6519298 chr22:42364997 C/T cg04733989 chr22:42467013 NAGA 0.4 6.49 0.33 3.03e-10 Cognitive function; LUSC cis rs738322 0.967 rs4380 chr22:38569529 T/C cg17652424 chr22:38574118 PLA2G6 -0.31 -6.67 -0.34 1.05e-10 Cutaneous nevi; LUSC cis rs6987853 0.933 rs2974340 chr8:42397731 T/C cg09913449 chr8:42400586 C8orf40 0.49 8.26 0.41 3.35e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg04267008 chr7:1944627 MAD1L1 0.64 9.97 0.48 1.12e-20 Bipolar disorder and schizophrenia; LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.0 -0.58 1.54e-31 Platelet count; LUSC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg13390004 chr1:15929781 NA 0.41 6.91 0.35 2.44e-11 Systolic blood pressure; LUSC cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.83 -0.3 1.27e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC trans rs10802346 0.545 rs10802347 chr1:246374268 G/A cg13514129 chr1:39547527 MACF1 0.71 11.62 0.54 1.96e-26 Fractional exhaled nitric oxide (childhood); LUSC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.38e-9 Crohn's disease; LUSC trans rs6076960 0.629 rs6054008 chr20:6212370 C/T cg17788362 chr6:86352627 SYNCRIP 0.43 6.48 0.33 3.38e-10 Smooth-surface caries; LUSC cis rs3981351 0.528 rs12768908 chr10:115443894 C/T cg24846397 chr10:115438155 CASP7 -0.39 -6.59 -0.34 1.76e-10 Obesity-related traits; LUSC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.69 -0.39 1.63e-13 Personality dimensions; LUSC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg13770153 chr20:60521292 NA -0.72 -9.87 -0.48 2.45e-20 Body mass index; LUSC cis rs3740713 1.000 rs75740864 chr11:18470689 C/G cg15463284 chr11:18477534 LDHAL6A -0.5 -5.73 -0.3 2.21e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs68092024 0.731 rs792841 chr3:99471308 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.38 -5.8 -0.3 1.52e-8 Cleft lip with or without cleft palate; LUSC cis rs67460515 0.563 rs16831886 chr3:160799830 A/C cg03342759 chr3:160939853 NMD3 -0.45 -6.01 -0.31 4.9e-9 Parkinson's disease; LUSC cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.81 0.3 1.48e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7246657 1.000 rs7246657 chr19:37747108 C/T cg23950597 chr19:37808831 NA 0.61 7.52 0.38 4.98e-13 Coronary artery calcification; LUSC cis rs11645898 0.748 rs11641424 chr16:72066879 C/T cg14768367 chr16:72042858 DHODH -0.75 -8.07 -0.4 1.32e-14 Blood protein levels; LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 16.11 0.66 1.32e-43 Platelet count; LUSC cis rs7267979 0.966 rs6050611 chr20:25414419 A/G cg08601574 chr20:25228251 PYGB 0.42 6.4 0.33 5.18e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs174775 0.513 rs2283849 chr22:29743482 T/C cg07256473 chr22:29710276 RASL10A -0.44 -8.12 -0.41 8.8e-15 Immature fraction of reticulocytes; LUSC cis rs11190604 1.000 rs7080356 chr10:102266735 A/C cg23241863 chr10:102295624 HIF1AN 0.49 6.17 0.32 1.98e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3815700 0.920 rs10424732 chr19:33096487 C/T cg02997394 chr19:33096574 ANKRD27 0.82 9.17 0.45 4.89e-18 Eosinophilic esophagitis; LUSC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg12311346 chr5:56204834 C5orf35 -0.6 -9.31 -0.45 1.7e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs17286411 0.750 rs4788568 chr16:71913025 C/T cg03805757 chr16:71968109 PKD1L3 0.42 6.89 0.35 2.77e-11 Blood protein levels; LUSC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg23887609 chr12:130822674 PIWIL1 -0.43 -6.56 -0.34 2.03e-10 Menopause (age at onset); LUSC cis rs6598955 0.614 rs1134584 chr1:26608828 G/A cg00852783 chr1:26633632 UBXN11 0.48 8.47 0.42 8.07e-16 Obesity-related traits; LUSC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg12311346 chr5:56204834 C5orf35 -0.9 -13.02 -0.58 1.22e-31 Initial pursuit acceleration; LUSC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg13939156 chr17:80058883 NA -0.34 -6.75 -0.35 6.49e-11 Life satisfaction; LUSC cis rs9399135 0.967 rs6902438 chr6:135336587 C/T cg22676075 chr6:135203613 NA 0.48 7.47 0.38 7.29e-13 Red blood cell count; LUSC cis rs2439831 0.764 rs12324584 chr15:43683446 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.54 0.46 3.16e-19 Lung cancer in ever smokers; LUSC cis rs9648716 0.515 rs79329624 chr7:140622362 T/C cg23214464 chr7:140373596 ADCK2 0.73 5.83 0.3 1.31e-8 Type 2 diabetes; LUSC cis rs7474896 0.616 rs1985260 chr10:38434090 C/T cg25427524 chr10:38739819 LOC399744 -0.5 -6.04 -0.31 4.1e-9 Obesity (extreme); LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg27535305 chr1:53392650 SCP2 -0.48 -9.51 -0.46 3.88e-19 Monocyte count; LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg04944784 chr2:26401820 FAM59B -0.74 -10.75 -0.51 2.39e-23 Gut microbiome composition (summer); LUSC cis rs10782582 0.609 rs78556436 chr1:76352875 G/A cg03433033 chr1:76189801 ACADM -0.39 -5.65 -0.3 3.42e-8 Daytime sleep phenotypes; LUSC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg11764359 chr7:65958608 NA -0.66 -10.57 -0.5 1e-22 Aortic root size; LUSC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg27170947 chr2:26402098 FAM59B -0.63 -9.15 -0.45 5.98e-18 Gut microbiome composition (summer); LUSC cis rs2439831 0.850 rs7163245 chr15:43671294 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.91 9.69 0.47 9.79e-20 Lung cancer in ever smokers; LUSC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.24e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9388451 0.839 rs9321054 chr6:126079968 A/G cg10911889 chr6:126070802 HEY2 -0.43 -6.6 -0.34 1.63e-10 Brugada syndrome; LUSC cis rs1559088 0.847 rs7254758 chr19:33608047 T/A cg03563238 chr19:33554763 RHPN2 -0.39 -6.14 -0.32 2.36e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.08e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1577917 0.682 rs6909767 chr6:86228109 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 7.36 0.37 1.42e-12 Response to antipsychotic treatment; LUSC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.47 -0.38 7.26e-13 Aortic root size; LUSC cis rs13040088 1.000 rs10854167 chr20:61533039 G/C cg23096297 chr20:61557774 DIDO1 0.84 11.57 0.53 2.85e-26 Menopause (age at onset); LUSC cis rs7103648 0.695 rs6485758 chr11:47530024 G/A cg20307385 chr11:47447363 PSMC3 0.85 13.39 0.59 5e-33 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs1577917 0.958 rs2324840 chr6:86557620 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs12617721 0.574 rs6542754 chr2:99025400 C/T cg10123293 chr2:99228465 UNC50 0.46 7.74 0.39 1.2e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.91e-9 Menopause (age at onset); LUSC cis rs7945705 0.846 rs4929912 chr11:8816695 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.33 -6.53 -0.34 2.5e-10 Hemoglobin concentration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15603734 chr19:2236704 PLEKHJ1;SF3A2 -0.41 -6.09 -0.32 3.07e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg02275930 chr1:2372054 NA -0.58 -10.0 -0.48 9.34e-21 Schizophrenia; LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg11062466 chr8:58055876 NA 0.66 9.08 0.44 9.89e-18 Developmental language disorder (linguistic errors); LUSC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg22549504 chr19:17448937 GTPBP3 0.54 6.77 0.35 5.67e-11 Systemic lupus erythematosus; LUSC cis rs6460942 0.630 rs62451487 chr7:12390464 G/A cg06484146 chr7:12443880 VWDE -0.57 -5.97 -0.31 6.08e-9 Coronary artery disease; LUSC cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg04455712 chr21:45112962 RRP1B 0.49 9.19 0.45 4.25e-18 Mean corpuscular volume; LUSC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.6 0.34 1.6e-10 Schizophrenia; LUSC cis rs1881797 0.527 rs74227706 chr1:247638315 A/C cg14830002 chr1:247616686 OR2B11 0.65 7.41 0.38 1.06e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg11608241 chr8:8085544 FLJ10661 0.51 7.46 0.38 7.57e-13 Neuroticism; LUSC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg05347473 chr6:146136440 FBXO30 0.51 8.58 0.43 3.52e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs11690935 0.885 rs10202823 chr2:172780132 T/C cg13550731 chr2:172543902 DYNC1I2 -0.8 -12.86 -0.58 5.09e-31 Schizophrenia; LUSC cis rs16912285 0.688 rs10834313 chr11:24348447 G/C ch.11.24196551F chr11:24239977 NA 0.83 7.83 0.39 6.33e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs11828289 0.660 rs11027043 chr11:23212893 C/T cg20040320 chr11:23191996 NA -0.58 -6.08 -0.32 3.32e-9 Cancer; LUSC cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.35e-22 Alzheimer's disease (late onset); LUSC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg21862992 chr11:68658383 NA 0.51 8.01 0.4 1.99e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7927771 0.524 rs7933184 chr11:47682402 C/T cg20307385 chr11:47447363 PSMC3 0.44 6.48 0.33 3.2e-10 Subjective well-being; LUSC cis rs73200209 0.744 rs56159580 chr12:116420448 T/C cg01776926 chr12:116560359 MED13L -0.52 -5.94 -0.31 7.14e-9 Total body bone mineral density; LUSC cis rs6961069 0.806 rs12706912 chr7:80252295 A/C cg04458919 chr7:80252533 CD36 -0.37 -6.69 -0.34 9.31e-11 Platelet count; LUSC cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.46e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs939658 0.805 rs34478496 chr15:79440997 C/A cg17916960 chr15:79447300 NA -0.53 -10.55 -0.5 1.24e-22 Refractive error; LUSC cis rs9300255 0.739 rs4759417 chr12:123746510 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.18 -0.32 1.82e-9 Neutrophil percentage of white cells; LUSC cis rs713587 0.525 rs11687089 chr2:25082926 T/C cg01884057 chr2:25150051 NA 0.41 9.23 0.45 3.08e-18 Body mass index in non-asthmatics; LUSC cis rs9527 0.830 rs11191440 chr10:104641511 G/A cg05855489 chr10:104503620 C10orf26 0.47 6.48 0.33 3.34e-10 Arsenic metabolism; LUSC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg00149659 chr3:10157352 C3orf10 0.62 8.72 0.43 1.36e-16 Alzheimer's disease; LUSC cis rs2191566 1.000 rs367499 chr19:44504981 G/A cg03039196 chr19:44506973 ZNF230 -0.38 -5.9 -0.31 8.99e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs738322 0.967 rs133018 chr22:38572761 G/A cg17652424 chr22:38574118 PLA2G6 -0.3 -6.58 -0.34 1.84e-10 Cutaneous nevi; LUSC cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg03676636 chr4:99064102 C4orf37 0.37 8.16 0.41 7.06e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg27068330 chr11:65405492 SIPA1 -0.44 -5.69 -0.3 2.71e-8 Breast cancer; LUSC cis rs9309473 0.583 rs6705203 chr2:73574600 T/C cg20560298 chr2:73613845 ALMS1 -0.56 -8.2 -0.41 5.2e-15 Metabolite levels; LUSC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg13175981 chr1:150552382 MCL1 0.47 6.7 0.34 9.06e-11 Tonsillectomy; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg13685329 chr2:73460476 CCT7;C2orf7 0.42 6.0 0.31 5.22e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs10761482 0.500 rs10821779 chr10:62274525 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.48 -0.33 3.39e-10 Schizophrenia; LUSC cis rs1028488 0.504 rs9460129 chr6:170696222 G/A cg20370364 chr6:170703943 FAM120B -0.49 -7.06 -0.36 9.5e-12 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg06637938 chr14:75390232 RPS6KL1 0.5 7.47 0.38 7.21e-13 Height; LUSC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg02711726 chr17:80685570 FN3KRP -0.4 -6.09 -0.32 3.17e-9 Glycated hemoglobin levels; LUSC cis rs9326248 0.559 rs4938334 chr11:116931042 G/C cg01368799 chr11:117014884 PAFAH1B2 0.61 9.31 0.45 1.77e-18 Blood protein levels; LUSC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg24060327 chr5:131705240 SLC22A5 -0.43 -7.15 -0.36 5.49e-12 Blood metabolite levels; LUSC cis rs8018967 0.622 rs2041073 chr14:73972535 C/T cg08936952 chr14:74026160 HEATR4 -0.36 -6.71 -0.34 8.34e-11 Blood metabolite ratios; LUSC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2067615 0.579 rs12312782 chr12:107135647 G/A cg15890332 chr12:107067104 RFX4 0.33 6.11 0.32 2.82e-9 Heart rate; LUSC cis rs11640533 1.000 rs11640533 chr16:53412862 A/G cg09728985 chr16:53543985 NA 0.3 5.82 0.3 1.41e-8 Intelligence (multi-trait analysis); LUSC cis rs262150 1.000 rs262149 chr7:158778256 A/G cg19418458 chr7:158789849 NA 0.53 8.48 0.42 7.42e-16 Facial morphology (factor 20); LUSC cis rs877282 0.947 rs7923867 chr10:768094 G/A cg17470449 chr10:769945 NA 0.55 7.78 0.39 9.07e-14 Uric acid levels; LUSC cis rs12579753 1.000 rs17749267 chr12:82178308 A/G cg21231944 chr12:82153410 PPFIA2 0.39 6.03 0.31 4.26e-9 Resting heart rate; LUSC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg23630131 chr7:65973040 NA -0.2 -5.64 -0.3 3.55e-8 Aortic root size; LUSC cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.42e-16 Menopause (age at onset); LUSC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11644478 chr21:40555479 PSMG1 -0.77 -13.52 -0.59 1.54e-33 Cognitive function; LUSC cis rs8179 0.700 rs42041 chr7:92246744 C/G cg15732164 chr7:92237376 CDK6 -0.46 -6.44 -0.33 4.1e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg09044154 chr16:88155775 NA -0.55 -7.36 -0.37 1.48e-12 Menopause (age at onset); LUSC cis rs1865721 0.804 rs7229401 chr18:73148127 T/G cg26385618 chr18:73139727 C18orf62 -0.52 -9.51 -0.46 3.94e-19 Intelligence; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25632300 chr5:174905618 SFXN1 -0.35 -6.68 -0.34 1.01e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.75e-12 Blood metabolite levels; LUSC cis rs713587 0.563 rs2384057 chr2:25100167 C/G cg01884057 chr2:25150051 NA 0.45 10.42 0.5 3.41e-22 Body mass index in non-asthmatics; LUSC cis rs3849570 0.673 rs13068700 chr3:81975817 G/C cg07356753 chr3:81810745 GBE1 -0.57 -8.23 -0.41 4.36e-15 Waist circumference;Body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09755102 chr1:33283495 S100PBP;YARS 0.45 6.95 0.36 1.92e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg06740227 chr12:86229804 RASSF9 0.39 6.33 0.33 7.71e-10 Major depressive disorder; LUSC trans rs17685 0.753 rs4732542 chr7:75663203 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 20.03 0.74 3.52e-59 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4423214 0.879 rs1790345 chr11:71145941 G/A cg05163923 chr11:71159392 DHCR7 -0.69 -9.03 -0.44 1.35e-17 Vitamin D levels; LUSC cis rs394563 0.625 rs384306 chr6:149796140 A/G cg11245181 chr6:149772854 ZC3H12D -0.34 -6.96 -0.36 1.76e-11 Dupuytren's disease; LUSC trans rs6601327 0.641 rs6601350 chr8:9573956 C/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.59 -0.34 1.71e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs9583531 0.628 rs9521914 chr13:111382231 C/A cg24331049 chr13:111365604 ING1 0.55 7.36 0.37 1.48e-12 Coronary artery disease; LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg27572855 chr1:25598939 RHD 0.47 8.58 0.42 3.74e-16 Erythrocyte sedimentation rate; LUSC cis rs16937 0.711 rs10751430 chr1:205107497 A/G cg00857998 chr1:205179979 DSTYK 0.47 6.59 0.34 1.71e-10 Schizophrenia; LUSC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg14983838 chr19:29218262 NA 0.65 9.14 0.45 6.14e-18 Methadone dose in opioid dependence; LUSC cis rs10464366 0.746 rs4723821 chr7:39141532 A/G cg15212455 chr7:39170539 POU6F2 0.61 9.78 0.47 4.97e-20 IgG glycosylation; LUSC cis rs4845459 0.967 rs9633406 chr1:152591446 C/G cg08895932 chr1:152778580 LCE1C -0.37 -6.35 -0.33 6.86e-10 Psoriasis; LUSC cis rs1538970 0.847 rs1771550 chr1:45883565 C/T cg05343316 chr1:45956843 TESK2 -0.6 -8.38 -0.42 1.47e-15 Platelet count; LUSC trans rs8072100 0.967 rs2317826 chr17:45730899 C/T cg04995722 chr7:26192034 NFE2L3 -0.37 -6.05 -0.31 3.95e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18163118 chr11:67250585 AIP -0.48 -6.31 -0.33 8.93e-10 Bipolar disorder and schizophrenia; LUSC cis rs3741151 0.686 rs11544310 chr11:73107592 A/G cg17517138 chr11:73019481 ARHGEF17 0.9 8.32 0.41 2.21e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs5753618 0.561 rs1858821 chr22:31676454 T/C cg22777020 chr22:31556080 RNF185 -0.47 -5.94 -0.31 7.04e-9 Colorectal cancer; LUSC cis rs4474465 1.000 rs873311 chr11:78145886 G/C cg27205649 chr11:78285834 NARS2 -0.53 -6.11 -0.32 2.8e-9 Alzheimer's disease (survival time); LUSC cis rs7089973 0.523 rs7099590 chr10:116749706 G/A cg23260525 chr10:116636907 FAM160B1 0.29 5.75 0.3 1.97e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs877282 0.891 rs11253393 chr10:788824 G/T cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC trans rs2797160 1.000 rs6904992 chr6:126016003 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.88 0.35 3.01e-11 Endometrial cancer; LUSC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs7824557 0.527 rs2736298 chr8:11235136 C/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.35 -0.33 6.93e-10 Retinal vascular caliber; LUSC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.47e-16 Developmental language disorder (linguistic errors); LUSC cis rs1505368 0.817 rs1283310 chr2:213273891 A/G cg16329650 chr2:213403929 ERBB4 0.52 7.87 0.4 4.93e-14 Symmetrical dimethylarginine levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg12940557 chr2:198299971 SF3B1 -0.43 -6.04 -0.31 4.13e-9 Hepatitis; LUSC cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs7598759 0.712 rs12991636 chr2:232333666 T/C cg19187155 chr2:232395269 NMUR1 0.48 7.03 0.36 1.15e-11 Noise-induced hearing loss; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg23131131 chr22:24373011 LOC391322 0.5 7.29 0.37 2.29e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6733011 0.578 rs12712038 chr2:99497710 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.79 -0.3 1.67e-8 Bipolar disorder; LUSC cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg00857998 chr1:205179979 DSTYK 0.57 8.58 0.43 3.5e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs11579220 1 rs11579220 chr1:205144363 G/T cg21545522 chr1:205238299 TMCC2 0.46 8.35 0.42 1.82e-15 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg08200582 chr11:442649 ANO9 -0.52 -5.96 -0.31 6.31e-9 Body mass index; LUSC cis rs6542838 0.704 rs12474283 chr2:99527310 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -6.15 -0.32 2.19e-9 Fear of minor pain; LUSC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg11764359 chr7:65958608 NA 0.58 8.82 0.43 6.39e-17 Aortic root size; LUSC cis rs7584330 0.737 rs61212490 chr2:238365230 T/C cg14458575 chr2:238380390 NA 0.68 12.06 0.55 4.8e-28 Prostate cancer; LUSC cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg14061069 chr19:46274453 DMPK -0.54 -9.24 -0.45 2.85e-18 Coronary artery disease; LUSC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg18099408 chr3:52552593 STAB1 -0.4 -6.78 -0.35 5.36e-11 Bipolar disorder; LUSC cis rs7123876 0.587 rs72962169 chr11:72365669 C/T cg04827223 chr11:72435913 ARAP1 -0.63 -7.42 -0.38 9.67e-13 Body mass index; LUSC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.1e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg04455712 chr21:45112962 RRP1B 0.48 8.88 0.44 4.18e-17 Mean corpuscular volume; LUSC cis rs3796619 1.000 rs12647929 chr4:1092019 G/T cg27284194 chr4:1044797 NA 0.49 7.77 0.39 9.7e-14 Recombination rate (males); LUSC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg10909506 chr17:38081995 ORMDL3 0.34 6.08 0.32 3.23e-9 Self-reported allergy; LUSC cis rs7089973 0.604 rs2420067 chr10:116590348 A/G cg03647239 chr10:116582469 FAM160B1 0.45 7.27 0.37 2.55e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.87 -0.31 1.03e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.1 0.66 1.44e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9309473 0.519 rs35421685 chr2:73910138 T/C cg20560298 chr2:73613845 ALMS1 0.41 6.25 0.32 1.28e-9 Metabolite levels; LUSC cis rs6005807 0.719 rs9625514 chr22:29022188 T/C cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.23e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7818345 0.967 rs4921638 chr8:19274793 C/A cg11303988 chr8:19266685 CSGALNACT1 0.36 6.92 0.35 2.31e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs2486288 0.656 rs11637920 chr15:45550905 T/C cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.8 -0.51 1.62e-23 Glomerular filtration rate; LUSC cis rs7089973 0.604 rs11196943 chr10:116598865 T/C cg23260525 chr10:116636907 FAM160B1 0.43 9.23 0.45 3.24e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.32 -0.37 1.81e-12 Menarche (age at onset); LUSC cis rs1018836 0.665 rs7000724 chr8:91516335 A/T cg16814680 chr8:91681699 NA -0.72 -10.92 -0.51 6.18e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg16434002 chr17:42200994 HDAC5 -0.46 -6.61 -0.34 1.54e-10 Total body bone mineral density; LUSC cis rs7385804 0.761 rs1617640 chr7:100317298 C/A cg16850897 chr7:100343110 ZAN 0.38 6.26 0.32 1.17e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11644478 chr21:40555479 PSMG1 -0.94 -17.96 -0.7 6.19e-51 Cognitive function; LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -16.97 -0.68 4.92e-47 Monocyte count; LUSC cis rs7123876 0.553 rs12099027 chr11:72433920 A/G cg04827223 chr11:72435913 ARAP1 -0.72 -12.8 -0.57 8.64e-31 Body mass index; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12935497 chr15:82339233 MEX3B 0.41 6.1 0.32 2.89e-9 Asthma; LUSC cis rs4077468 1.000 rs9662221 chr1:205915745 G/T cg24503407 chr1:205819492 PM20D1 -0.44 -6.24 -0.32 1.3e-9 Cystic fibrosis-related diabetes; LUSC cis rs3808502 0.549 rs11991139 chr8:11428395 C/T cg21775007 chr8:11205619 TDH -0.59 -8.52 -0.42 5.4e-16 Neuroticism; LUSC cis rs7202877 0.656 rs9923834 chr16:75507253 T/A cg03315344 chr16:75512273 CHST6 0.42 6.06 0.31 3.71e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7607369 0.719 rs12613545 chr2:219623504 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.49 3.15e-21 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -7.69 -0.39 1.68e-13 Longevity;Endometriosis; LUSC cis rs11122272 0.735 rs2486734 chr1:231531392 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.25 -0.49 1.32e-21 Hemoglobin concentration; LUSC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.64 -7.28 -0.37 2.37e-12 Diabetic retinopathy; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg08736216 chr1:53307985 ZYG11A -0.28 -5.73 -0.3 2.2e-8 Monocyte count; LUSC cis rs73198271 0.595 rs56152067 chr8:8592992 G/A cg01851573 chr8:8652454 MFHAS1 0.46 5.75 0.3 2.04e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs79349575 0.783 rs4294857 chr17:46983391 G/A cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs1113500 0.548 rs7541433 chr1:108645641 G/A cg06207961 chr1:108661230 NA 0.34 5.68 0.3 2.93e-8 Growth-regulated protein alpha levels; LUSC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg20203395 chr5:56204925 C5orf35 0.58 8.55 0.42 4.48e-16 Initial pursuit acceleration; LUSC cis rs73198271 0.531 rs17630714 chr8:8657681 C/T cg01851573 chr8:8652454 MFHAS1 0.67 8.75 0.43 1.11e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3755132 1.000 rs60016948 chr2:15728544 G/T cg12888861 chr2:15731646 DDX1 0.53 7.59 0.38 3.24e-13 Wilms tumor; LUSC cis rs829883 0.966 rs249815 chr12:98893709 A/G cg25150519 chr12:98850993 NA 0.64 9.72 0.47 7.74e-20 Colorectal adenoma (advanced); LUSC cis rs10782582 0.586 rs112368938 chr1:76336339 C/T cg10523679 chr1:76189770 ACADM -0.47 -6.7 -0.34 8.69e-11 Daytime sleep phenotypes; LUSC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -8.16 -0.41 6.99e-15 Hemoglobin concentration; LUSC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg04871131 chr7:94954202 PON1 -0.39 -6.11 -0.32 2.7e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2839186 0.749 rs62226488 chr21:47710517 C/T cg13126279 chr21:47581558 C21orf56 -0.42 -6.14 -0.32 2.3e-9 Testicular germ cell tumor; LUSC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.92e-23 Gut microbiome composition (summer); LUSC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg01849466 chr14:104193079 ZFYVE21 -0.55 -7.88 -0.4 4.53e-14 Reticulocyte count; LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg16325326 chr1:53192061 ZYG11B 0.71 11.61 0.54 2.03e-26 Monocyte count; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg24388789 chr13:24463533 MIPEP;PCOTH 0.46 6.02 0.31 4.55e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6088813 0.961 rs6060371 chr20:33913322 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.09 -0.32 3.08e-9 Height; LUSC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs7481584 0.624 rs693687 chr11:3052494 A/G cg25174290 chr11:3078921 CARS -0.41 -6.03 -0.31 4.44e-9 Calcium levels; LUSC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.75e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg11608241 chr8:8085544 FLJ10661 0.4 5.8 0.3 1.55e-8 Mood instability; LUSC cis rs4363385 0.747 rs61811427 chr1:152968419 C/T cg00922841 chr1:152955080 SPRR1A -0.45 -7.86 -0.39 5.51e-14 Inflammatory skin disease; LUSC cis rs2429369 0.528 rs2526376 chr17:56427142 A/C cg05425664 chr17:57184151 TRIM37 -0.4 -5.92 -0.31 8.06e-9 Cognitive function; LUSC cis rs265548 0.538 rs36688 chr19:17911212 A/C cg21960279 chr19:17905606 B3GNT3 0.39 6.07 0.32 3.56e-9 Tumor biomarkers; LUSC cis rs2290159 0.948 rs11711270 chr3:12639596 C/T cg23032965 chr3:12705835 RAF1 0.54 7.01 0.36 1.32e-11 Cholesterol, total; LUSC cis rs7267979 1.000 rs2257808 chr20:25266450 G/C cg08601574 chr20:25228251 PYGB 0.43 6.6 0.34 1.59e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs782590 0.837 rs2627769 chr2:55927288 G/C cg03859395 chr2:55845619 SMEK2 0.84 14.79 0.63 2.08e-38 Metabolic syndrome; LUSC cis rs9814567 0.929 rs1863911 chr3:134205231 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.86 -14.52 -0.62 2.16e-37 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11098499 0.954 rs2389802 chr4:120325732 C/A cg09307838 chr4:120376055 NA 0.76 10.86 0.51 9.89e-24 Corneal astigmatism; LUSC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.83 -0.3 1.34e-8 Tonsillectomy; LUSC cis rs6690583 0.623 rs893618 chr1:85513770 C/T cg11262906 chr1:85462892 MCOLN2 0.67 6.12 0.32 2.68e-9 Serum sulfate level; LUSC trans rs953492 0.672 rs1766030 chr1:243314577 C/T cg25284624 chr1:224180302 NA -0.5 -7.78 -0.39 9.01e-14 Diastolic blood pressure; LUSC cis rs877282 0.891 rs11253406 chr10:796297 G/A cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs12477438 0.765 rs13406288 chr2:99589585 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.66 -0.57 2.86e-30 Chronic sinus infection; LUSC cis rs2639990 1.000 rs1702831 chr18:72897368 C/A cg11568697 chr18:72916393 ZADH2 0.56 6.49 0.33 3.16e-10 Vascular endothelial growth factor levels; LUSC cis rs3020736 0.500 rs28791586 chr22:42500483 A/G cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4144743 1.000 rs4144745 chr17:45323349 T/C cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs6674970 0.748 rs56299877 chr1:151115645 C/T cg11822372 chr1:151115635 SEMA6C -0.93 -15.48 -0.65 4.08e-41 Childhood ear infection; LUSC cis rs2439831 0.867 rs11856184 chr15:43919162 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC cis rs765787 0.530 rs1648287 chr15:45516956 T/C cg25801113 chr15:45476975 SHF 0.33 6.83 0.35 4.06e-11 Uric acid levels; LUSC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg06618935 chr21:46677482 NA -0.37 -7.52 -0.38 5.25e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg08859206 chr1:53392774 SCP2 -0.53 -9.2 -0.45 3.85e-18 Monocyte count; LUSC cis rs1728785 1.000 rs1170429 chr16:68604126 A/G cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC cis rs66686620 1.000 rs6546473 chr2:69260357 C/T cg12800200 chr2:69260302 ANTXR1 0.4 6.2 0.32 1.7e-9 Breast cancer; LUSC cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg03684893 chr10:554711 DIP2C -0.37 -6.76 -0.35 6.33e-11 Psychosis in Alzheimer's disease; LUSC cis rs7786808 0.644 rs4909081 chr7:158200785 G/A cg01191920 chr7:158217561 PTPRN2 -0.53 -10.89 -0.51 7.94e-24 Obesity-related traits; LUSC cis rs4319547 0.620 rs12372756 chr12:122815130 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.32 -0.41 2.26e-15 Body mass index; LUSC cis rs6722750 0.818 rs12104940 chr2:64385774 A/G cg22352474 chr2:64371530 PELI1 0.64 10.01 0.48 8.15e-21 Neuroticism; LUSC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.21 0.59 2.51e-32 Cognitive test performance; LUSC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg00369194 chr7:157950511 PTPRN2 0.31 6.21 0.32 1.53e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs6952808 0.798 rs28970524 chr7:1927484 C/T cg04565464 chr8:145669602 NFKBIL2 0.39 6.51 0.34 2.77e-10 Bipolar disorder and schizophrenia; LUSC trans rs453301 0.571 rs330054 chr8:9088291 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -8.28 -0.41 3.08e-15 Joint mobility (Beighton score); LUSC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg09034736 chr1:150693464 HORMAD1 -0.4 -5.72 -0.3 2.41e-8 Lymphocyte counts; LUSC cis rs2197308 0.703 rs10880251 chr12:37903297 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs2204008 0.536 rs12368354 chr12:38042798 G/A cg13010199 chr12:38710504 ALG10B 0.71 10.9 0.51 7.24e-24 Bladder cancer; LUSC cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg02527881 chr3:46936655 PTH1R 0.4 7.09 0.36 7.98e-12 Colorectal cancer; LUSC cis rs6500395 1.000 rs1477134 chr16:48706973 G/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2235642 0.859 rs12599207 chr16:1606445 A/G cg26528668 chr16:1614120 IFT140 0.46 7.71 0.39 1.48e-13 Coronary artery disease; LUSC cis rs9311676 0.632 rs62258075 chr3:58359851 G/A cg26110898 chr3:58419937 PDHB 0.4 6.53 0.34 2.46e-10 Systemic lupus erythematosus; LUSC cis rs9650657 0.504 rs10108347 chr8:11033517 G/C cg21775007 chr8:11205619 TDH -0.54 -7.87 -0.4 5.07e-14 Neuroticism; LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.51 -6.82 -0.35 4.27e-11 Renal function-related traits (BUN); LUSC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.66 -0.34 1.15e-10 Lung cancer; LUSC cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.08 0.32 3.26e-9 Personality dimensions; LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.38 0.67 1.08e-44 Platelet count; LUSC cis rs2658782 0.547 rs4753453 chr11:93041174 T/G cg15737290 chr11:93063684 CCDC67 0.9 13.82 0.6 1.15e-34 Pulmonary function decline; LUSC cis rs1865760 0.534 rs72834629 chr6:26023032 C/T cg16482183 chr6:26056742 HIST1H1C 0.62 8.41 0.42 1.18e-15 Height; LUSC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg19346786 chr7:2764209 NA -0.4 -6.72 -0.35 7.79e-11 Height; LUSC cis rs9715521 0.677 rs62301200 chr4:59855179 G/A cg11281224 chr4:60001000 NA -0.5 -7.03 -0.36 1.18e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7072216 0.770 rs1739 chr10:100176339 A/G cg26618903 chr10:100175079 PYROXD2 -0.34 -6.47 -0.33 3.58e-10 Metabolite levels; LUSC cis rs12291225 0.645 rs3763950 chr11:14278049 T/A cg19336497 chr11:14380999 RRAS2 -0.56 -11.61 -0.54 2.14e-26 Sense of smell; LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg16325326 chr1:53192061 ZYG11B -0.9 -16.97 -0.68 4.92e-47 Monocyte count; LUSC trans rs7937682 0.824 rs510866 chr11:111484113 A/C cg18187862 chr3:45730750 SACM1L 0.52 6.83 0.35 4e-11 Primary sclerosing cholangitis; LUSC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg14668632 chr7:2872130 GNA12 -0.42 -6.19 -0.32 1.77e-9 Height; LUSC cis rs6545883 0.894 rs778143 chr2:61581890 A/C cg15711740 chr2:61764176 XPO1 -0.44 -6.66 -0.34 1.15e-10 Tuberculosis; LUSC cis rs1215050 0.740 rs783963 chr4:98989070 A/G cg03676636 chr4:99064102 C4orf37 0.28 6.17 0.32 1.98e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg13395646 chr4:1353034 KIAA1530 -0.56 -8.51 -0.42 5.88e-16 Longevity; LUSC cis rs1878931 0.507 rs11648783 chr16:3406626 A/G cg22508957 chr16:3507546 NAT15 -0.41 -5.93 -0.31 7.71e-9 Body mass index (adult); LUSC cis rs2463822 0.513 rs72919445 chr11:62029078 A/C cg06239285 chr11:62104954 ASRGL1 -0.59 -5.97 -0.31 6.07e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7917772 0.604 rs7908249 chr10:104373300 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.08 0.52 1.68e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2562456 0.833 rs62110429 chr19:21613786 C/T cg00806126 chr19:22604979 ZNF98 -0.4 -5.69 -0.3 2.73e-8 Pain; LUSC trans rs2898290 0.622 rs13272061 chr8:11352261 G/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.64 -0.43 2.32e-16 Systolic blood pressure; LUSC cis rs7107174 1.000 rs1567890 chr11:78101700 T/C cg02023728 chr11:77925099 USP35 0.46 6.7 0.34 8.82e-11 Testicular germ cell tumor; LUSC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.87 -0.35 3.19e-11 Menopause (age at onset); LUSC cis rs6469656 1.000 rs1436765 chr8:117652626 A/G cg24004040 chr8:117650383 NA -0.45 -6.46 -0.33 3.68e-10 Colorectal cancer; LUSC cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg08048268 chr3:133502702 NA 0.35 6.39 0.33 5.68e-10 Alcohol consumption (transferrin glycosylation); LUSC cis rs4144743 0.759 rs34251886 chr17:45320299 G/T cg18085866 chr17:45331354 ITGB3 -0.84 -7.94 -0.4 3.02e-14 Body mass index; LUSC trans rs1997103 0.954 rs940880 chr7:55392619 C/G cg20935933 chr6:143382018 AIG1 0.49 7.08 0.36 8.48e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs28830936 1.000 rs28754734 chr15:42093152 C/T cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.77 -0.3 1.78e-8 Diastolic blood pressure; LUSC cis rs2840044 1.000 rs8073935 chr17:33985849 C/T cg05299278 chr17:33885742 SLFN14 0.28 5.91 0.31 8.23e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs6754311 0.731 rs4954490 chr2:136608231 G/A cg25344623 chr2:136566232 LCT 0.4 5.94 0.31 6.98e-9 Mosquito bite size; LUSC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg18827107 chr12:86230957 RASSF9 0.5 7.36 0.37 1.43e-12 Major depressive disorder; LUSC cis rs4803468 0.967 rs7259900 chr19:41889429 A/T cg09537434 chr19:41945824 ATP5SL -0.89 -15.66 -0.65 7.6e-42 Height; LUSC cis rs4842666 0.915 rs12579302 chr12:90050503 C/T cg00757033 chr12:89920650 WDR51B -0.42 -6.06 -0.31 3.59e-9 Blood pressure; LUSC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.96 -0.31 6.47e-9 Alzheimer's disease (late onset); LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg04267008 chr7:1944627 MAD1L1 -0.58 -8.63 -0.43 2.52e-16 Bipolar disorder and schizophrenia; LUSC trans rs11250097 0.535 rs11250086 chr8:10769783 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.39 -0.37 1.16e-12 Neuroticism; LUSC cis rs7523273 0.606 rs2761433 chr1:207917361 G/A cg22525895 chr1:207977042 MIR29B2 0.4 6.62 0.34 1.42e-10 Schizophrenia; LUSC cis rs6964587 1.000 rs733957 chr7:91707197 C/T cg22709100 chr7:91322751 NA 0.39 5.75 0.3 1.98e-8 Breast cancer; LUSC cis rs3540 0.597 rs1978149 chr15:91036976 A/G cg10434728 chr15:90938212 IQGAP1 0.45 9.08 0.45 9.44e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg12564285 chr5:131593104 PDLIM4 0.45 7.79 0.39 8.44e-14 Breast cancer; LUSC cis rs6424115 0.800 rs6665733 chr1:24200158 T/C cg15997130 chr1:24165203 NA 0.52 8.54 0.42 4.67e-16 Immature fraction of reticulocytes; LUSC cis rs11190604 1.000 rs9419897 chr10:102246125 T/C cg16342193 chr10:102329863 NA -0.34 -6.27 -0.32 1.1e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11758351 1.000 rs3757135 chr6:26200707 G/A cg23601095 chr6:26197514 HIST1H3D 0.75 7.59 0.38 3.21e-13 Gout;Renal underexcretion gout; LUSC cis rs9921338 0.961 rs56010295 chr16:11378907 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.96 -0.36 1.78e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs6665290 0.901 rs3795453 chr1:227205331 A/G cg10327440 chr1:227177885 CDC42BPA -1.23 -39.96 -0.91 2.76e-129 Myeloid white cell count; LUSC trans rs10506458 1.000 rs12580997 chr12:63433420 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -15.62 -0.65 1.1e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs113835537 0.597 rs11227527 chr11:66313026 A/G cg24851651 chr11:66362959 CCS 0.53 7.84 0.39 6.15e-14 Airway imaging phenotypes; LUSC trans rs7893279 0.822 rs6482408 chr10:18715540 A/G cg01840055 chr3:141338555 NA 0.5 5.99 0.31 5.41e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg04944784 chr2:26401820 FAM59B -0.75 -10.71 -0.51 3.38e-23 Gut microbiome composition (summer); LUSC cis rs2153535 1.000 rs2153535 chr6:8369679 C/G cg21535247 chr6:8435926 SLC35B3 -0.45 -6.53 -0.34 2.38e-10 Motion sickness; LUSC cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg04545296 chr12:48745243 ZNF641 0.37 6.75 0.35 6.61e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18404041 chr3:52824283 ITIH1 -0.54 -10.39 -0.49 4.23e-22 Electroencephalogram traits; LUSC trans rs1997103 0.911 rs6949931 chr7:55391081 T/C cg20935933 chr6:143382018 AIG1 0.5 7.2 0.37 3.9e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg17143192 chr8:8559678 CLDN23 0.63 9.03 0.44 1.37e-17 Obesity-related traits; LUSC cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg14993813 chr1:46806288 NSUN4 0.49 6.97 0.36 1.7e-11 Menopause (age at onset); LUSC cis rs983392 0.651 rs718376 chr11:60002935 C/T cg24026212 chr11:59952134 MS4A6A -0.34 -5.84 -0.3 1.25e-8 Alzheimer's disease (late onset); LUSC cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.24e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21284376 chr1:72748601 NEGR1 0.38 6.31 0.33 8.81e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01398415 chr1:226309536 NA 0.43 6.47 0.33 3.41e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3125734 0.633 rs4979772 chr10:63967600 C/T cg09941381 chr10:64027924 RTKN2 0.4 7.44 0.38 8.63e-13 Rheumatoid arthritis; LUSC cis rs2014572 1.000 rs3746231 chr19:57760057 G/A cg24459738 chr19:57751996 ZNF805 -0.51 -7.53 -0.38 4.91e-13 Hyperactive-impulsive symptoms; LUSC trans rs7746199 0.736 rs58616630 chr6:27474715 A/G cg06606381 chr12:133084897 FBRSL1 -0.99 -9.31 -0.45 1.78e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1371867 0.846 rs1788197 chr8:101290928 T/C cg00191853 chr8:101177733 SPAG1 -0.38 -6.31 -0.33 8.89e-10 Atrioventricular conduction; LUSC cis rs983392 0.559 rs1426249 chr11:60002261 C/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.92 -0.31 8.14e-9 Alzheimer's disease (late onset); LUSC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs7100689 0.577 rs2282367 chr10:82040346 A/G cg00277334 chr10:82204260 NA -0.46 -6.41 -0.33 5.07e-10 Post bronchodilator FEV1; LUSC cis rs10189230 0.967 rs13026378 chr2:222352712 G/A cg14652038 chr2:222343519 EPHA4 0.32 5.76 0.3 1.91e-8 Urate levels in lean individuals; LUSC cis rs9616064 0.531 rs867212 chr22:47063330 C/T cg25730555 chr22:47059586 GRAMD4 -0.43 -6.94 -0.36 2e-11 Urate levels in obese individuals; LUSC cis rs259282 0.605 rs3760939 chr19:33106911 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.64 9.64 0.47 1.49e-19 Schizophrenia; LUSC cis rs4654899 1.000 rs10916938 chr1:21446883 A/G cg01072550 chr1:21505969 NA -0.51 -7.86 -0.39 5.44e-14 Superior frontal gyrus grey matter volume; LUSC cis rs3799379 0.550 rs2072804 chr6:26391190 G/A cg09904177 chr6:26538194 HMGN4 -0.51 -6.87 -0.35 3.09e-11 Intelligence (multi-trait analysis); LUSC cis rs7914558 0.902 rs7092200 chr10:104844872 T/C cg04362960 chr10:104952993 NT5C2 0.53 8.05 0.4 1.51e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg08219700 chr8:58056026 NA 0.59 6.96 0.36 1.8e-11 Developmental language disorder (linguistic errors); LUSC cis rs7647973 0.961 rs11130187 chr3:49307872 T/C cg06212747 chr3:49208901 KLHDC8B 0.45 5.7 0.3 2.57e-8 Menarche (age at onset); LUSC cis rs3820928 0.874 rs10194663 chr2:227875369 T/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.75 -0.39 1.09e-13 Pulmonary function; LUSC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg06462663 chr19:18546047 ISYNA1 0.5 8.52 0.42 5.69e-16 Breast cancer; LUSC cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg20848291 chr7:100343083 ZAN -0.61 -8.43 -0.42 1.07e-15 Other erythrocyte phenotypes; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.77 0.39 1e-13 Lymphocyte counts; LUSC trans rs62238980 0.614 rs75348576 chr22:32395467 A/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg08439880 chr3:133502540 NA -0.34 -6.12 -0.32 2.59e-9 Iron status biomarkers; LUSC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.36 0.42 1.77e-15 Tonsillectomy; LUSC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg22508957 chr16:3507546 NAT15 0.44 6.18 0.32 1.83e-9 Body mass index (adult); LUSC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg11752832 chr7:134001865 SLC35B4 0.55 8.4 0.42 1.32e-15 Mean platelet volume; LUSC cis rs394563 0.967 rs444784 chr6:149798366 C/G cg03678062 chr6:149772716 ZC3H12D -0.31 -6.43 -0.33 4.34e-10 Dupuytren's disease; LUSC cis rs9467711 0.720 rs3857546 chr6:26157762 C/T cg16898833 chr6:26189333 HIST1H4D 0.71 6.92 0.35 2.31e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1577917 0.958 rs12212480 chr6:86458777 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.5 -7.21 -0.37 3.69e-12 Response to antipsychotic treatment; LUSC cis rs2074585 0.517 rs11638010 chr15:91079920 A/G cg22089800 chr15:90895588 ZNF774 -0.57 -8.08 -0.4 1.17e-14 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs34734847 0.814 rs17847 chr12:121149475 A/G cg21892295 chr12:121157589 UNC119B -0.36 -6.3 -0.33 9.46e-10 Mean corpuscular volume; LUSC cis rs7607369 0.559 rs6741592 chr2:219658609 C/T cg02176678 chr2:219576539 TTLL4 -0.53 -9.18 -0.45 4.5e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7590720 1.000 rs6435930 chr2:216885852 A/G cg12620499 chr2:216877984 MREG 0.93 14.14 0.61 6.66e-36 Alcohol dependence; LUSC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg06618935 chr21:46677482 NA -0.39 -7.81 -0.39 7.65e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7917772 0.539 rs12572775 chr10:104285594 A/T cg05855489 chr10:104503620 C10orf26 0.45 6.91 0.35 2.44e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg04518342 chr5:131593106 PDLIM4 0.44 7.71 0.39 1.47e-13 Acylcarnitine levels; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.19 -0.32 1.8e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs559928 0.597 rs947939 chr11:63885287 C/T cg24687543 chr11:63912206 MACROD1 0.46 5.94 0.31 7.22e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg00800038 chr16:89945340 TCF25 -0.64 -6.63 -0.34 1.37e-10 Skin colour saturation; LUSC cis rs2625529 0.652 rs2929508 chr15:72246964 A/T cg16672083 chr15:72433130 SENP8 0.5 8.22 0.41 4.49e-15 Red blood cell count; LUSC cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg04972856 chr6:88032051 C6orf162;GJB7 0.43 8.05 0.4 1.51e-14 Monocyte percentage of white cells; LUSC cis rs34779708 0.733 rs7083266 chr10:35541632 C/A cg03585969 chr10:35415529 CREM 0.55 7.61 0.38 2.86e-13 Inflammatory bowel disease;Crohn's disease; LUSC trans rs11992162 1.000 rs7460395 chr8:11835375 C/T cg27411982 chr8:10470053 RP1L1 0.48 7.19 0.37 4.19e-12 Monocyte count; LUSC trans rs9784649 1.000 rs9784649 chr5:25011524 G/A cg08600765 chr20:34638493 LOC647979 -0.53 -6.09 -0.32 3.03e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs35883536 0.647 rs10875315 chr1:101044062 G/A cg06223162 chr1:101003688 GPR88 -0.49 -9.24 -0.45 2.89e-18 Monocyte count; LUSC cis rs28830936 0.510 rs12440605 chr15:42102285 A/G cg17847044 chr15:42102381 MAPKBP1 0.38 9.5 0.46 4.17e-19 Diastolic blood pressure; LUSC cis rs861020 0.606 rs4844903 chr1:210006267 C/T cg05527609 chr1:210001259 C1orf107 0.67 9.63 0.47 1.5700000000000001e-19 Orofacial clefts; LUSC cis rs11971779 0.648 rs6467852 chr7:139112591 A/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1953600 0.837 rs2236556 chr10:81932790 T/C cg04850286 chr10:81895943 PLAC9 0.34 5.98 0.31 5.82e-9 Sarcoidosis; LUSC cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg16339924 chr4:17578868 LAP3 -0.58 -8.39 -0.42 1.36e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.51 -0.34 2.69e-10 High light scatter reticulocyte count; LUSC cis rs2219968 0.828 rs1871788 chr8:78945481 T/C cg00738934 chr8:78996279 NA -0.38 -6.9 -0.35 2.59e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs9329221 0.537 rs12678797 chr8:9978919 A/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.5 -0.42 6.28e-16 Neuroticism; LUSC cis rs7605827 0.836 rs4396684 chr2:15634404 C/T cg19274914 chr2:15703543 NA 0.45 8.57 0.42 3.81e-16 Educational attainment (years of education); LUSC cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg04450456 chr4:17643702 FAM184B 0.41 6.98 0.36 1.62e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg21123913 chr4:89513664 HERC3 0.37 6.21 0.32 1.54e-9 Schizophrenia (age at onset); LUSC cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.14 0.49 3.03e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1256061 0.564 rs1256043 chr14:64734282 A/G cg23250157 chr14:64679961 SYNE2 0.32 5.7 0.3 2.68e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs6845621 0.727 rs10020540 chr4:18908628 T/C cg12196642 chr4:18937545 NA -0.33 -6.22 -0.32 1.45e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg15103426 chr22:29168792 CCDC117 0.46 6.02 0.31 4.71e-9 Lymphocyte counts; LUSC cis rs9325144 0.723 rs11169535 chr12:39183494 C/T cg13010199 chr12:38710504 ALG10B -0.5 -7.59 -0.38 3.32e-13 Morning vs. evening chronotype; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg20749510 chr20:62374070 SLC2A4RG -0.42 -6.96 -0.36 1.76e-11 Risky sexual behaviors in alcohol dependence; LUSC trans rs11992162 0.507 rs60902764 chr8:11784991 A/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.19 -0.32 1.79e-9 Monocyte count; LUSC cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg23788917 chr6:8435910 SLC35B3 -0.5 -7.42 -0.38 9.83e-13 Motion sickness; LUSC cis rs2652834 0.851 rs4468558 chr15:63346681 T/C cg05507819 chr15:63340323 TPM1 0.67 8.47 0.42 8.1e-16 HDL cholesterol; LUSC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg17971929 chr21:40555470 PSMG1 -0.51 -7.59 -0.38 3.3e-13 Menarche (age at onset); LUSC trans rs1493916 1.000 rs4393645 chr18:31394407 C/T cg27147174 chr7:100797783 AP1S1 -0.64 -10.24 -0.49 1.34e-21 Life satisfaction; LUSC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg00033643 chr7:134001901 SLC35B4 0.46 7.27 0.37 2.61e-12 Mean platelet volume; LUSC trans rs4927850 0.918 rs4361313 chr3:195752260 A/G cg16724585 chr3:197361211 NA -0.61 -8.66 -0.43 2e-16 Pancreatic cancer; LUSC cis rs7903847 0.642 rs2275581 chr10:99126249 G/A cg20016023 chr10:99160130 RRP12 -0.3 -6.35 -0.33 7.17e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs7605827 0.897 rs6734288 chr2:15526222 T/G cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs7197653 0.748 rs8060690 chr16:68340085 G/T cg05110241 chr16:68378359 PRMT7 -0.81 -8.41 -0.42 1.25e-15 Magnesium levels; LUSC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.16 -0.32 2.06e-9 Total body bone mineral density; LUSC cis rs1775715 0.870 rs10827001 chr10:32229734 C/T cg18675610 chr10:32216311 ARHGAP12 0.29 6.28 0.33 1.04e-9 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs11098499 0.954 rs10008459 chr4:120394231 T/C cg25214090 chr10:38739885 LOC399744 0.6 8.81 0.43 6.84e-17 Corneal astigmatism; LUSC cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg00254258 chr1:3105189 PRDM16 -0.3 -5.93 -0.31 7.57e-9 Migraine; LUSC cis rs4356932 1.000 rs4257674 chr4:76945685 A/G cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg18099408 chr3:52552593 STAB1 -0.35 -6.08 -0.32 3.22e-9 Electroencephalogram traits; LUSC cis rs870825 0.616 rs7682677 chr4:185640717 C/G cg04058563 chr4:185651563 MLF1IP 0.86 13.38 0.59 5.34e-33 Blood protein levels; LUSC cis rs4474465 1.000 rs10899523 chr11:78190808 C/T cg27205649 chr11:78285834 NARS2 -0.51 -6.1 -0.32 2.95e-9 Alzheimer's disease (survival time); LUSC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg15557168 chr22:42548783 NA -0.45 -6.88 -0.35 2.98e-11 Schizophrenia; LUSC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg16850897 chr7:100343110 ZAN -0.45 -5.65 -0.3 3.4e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg27572855 chr1:25598939 RHD -0.41 -7.11 -0.36 7.16e-12 Erythrocyte sedimentation rate; LUSC cis rs12681287 0.752 rs4389908 chr8:87274852 A/G cg27223183 chr8:87520930 FAM82B -0.46 -5.92 -0.31 7.82e-9 Caudate activity during reward; LUSC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.79 0.35 5.13e-11 Tonsillectomy; LUSC cis rs4654899 0.714 rs12133972 chr1:21091338 A/T cg01072550 chr1:21505969 NA -0.44 -6.53 -0.34 2.39e-10 Superior frontal gyrus grey matter volume; LUSC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08704250 chr15:31115839 NA -0.47 -6.97 -0.36 1.71e-11 Huntington's disease progression; LUSC cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg13010199 chr12:38710504 ALG10B 0.57 8.64 0.43 2.29e-16 Bladder cancer; LUSC cis rs9309473 0.500 rs4852953 chr2:73869908 G/A cg20560298 chr2:73613845 ALMS1 0.42 6.37 0.33 6.27e-10 Metabolite levels; LUSC cis rs694739 0.536 rs671976 chr11:64046029 G/A cg23796481 chr11:64053134 BAD;GPR137 0.4 6.78 0.35 5.41e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg20295408 chr7:1910781 MAD1L1 -0.47 -6.7 -0.34 8.92e-11 Bipolar disorder and schizophrenia; LUSC cis rs2108225 0.837 rs6466186 chr7:107446966 G/C cg18560240 chr7:107437656 SLC26A3 -0.4 -6.13 -0.32 2.43e-9 Ulcerative colitis; LUSC cis rs6952809 0.561 rs1548598 chr7:2438912 T/C cg23289794 chr7:2394357 EIF3B -0.7 -9.41 -0.46 8.6e-19 Multiple sclerosis; LUSC cis rs6484504 0.652 rs578666 chr11:31404484 C/T cg06552810 chr11:31128660 NA 0.37 6.1 0.32 2.99e-9 Red blood cell count; LUSC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg00677455 chr12:58241039 CTDSP2 0.53 6.57 0.34 1.92e-10 Multiple sclerosis; LUSC trans rs870142 0.883 rs931998 chr4:4639613 G/A cg04017672 chr1:182359056 GLUL 0.41 6.04 0.31 4.2e-9 Congenital heart disease; LUSC trans rs34421088 0.506 rs2409755 chr8:11169983 G/A cg06636001 chr8:8085503 FLJ10661 0.47 6.96 0.36 1.76e-11 Neuroticism; LUSC cis rs909002 1.000 rs1474182 chr1:32136398 C/T cg13919466 chr1:32135498 COL16A1 -0.32 -6.01 -0.31 4.8e-9 Intelligence (multi-trait analysis); LUSC cis rs250677 0.522 rs891920 chr5:148369418 G/T cg18129178 chr5:148520854 ABLIM3 -0.5 -7.29 -0.37 2.21e-12 Breast cancer; LUSC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.6 -8.18 -0.41 6.14e-15 Systemic lupus erythematosus; LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg01802117 chr1:53393560 SCP2 0.37 6.0 0.31 5.15e-9 Monocyte count; LUSC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg21361702 chr7:150065534 REPIN1 0.46 6.29 0.33 1.01e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6977660 0.943 rs10263564 chr7:19842898 G/C cg07541023 chr7:19748670 TWISTNB 0.53 6.06 0.31 3.64e-9 Thyroid stimulating hormone; LUSC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.36 5.68 0.3 2.87e-8 Vitiligo; LUSC cis rs2274273 1.000 rs11621351 chr14:55616740 C/A cg04306507 chr14:55594613 LGALS3 0.55 12.08 0.55 3.99e-28 Protein biomarker; LUSC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs9952991 0.883 rs11663253 chr18:12789556 A/G cg23598886 chr18:12777645 NA -0.58 -5.73 -0.3 2.22e-8 Inflammatory skin disease; LUSC cis rs9486715 0.838 rs4839840 chr6:96941149 T/C cg06623918 chr6:96969491 KIAA0776 0.94 17.57 0.69 2.21e-49 Headache; LUSC cis rs2404602 0.692 rs36070630 chr15:76949259 T/C cg26408565 chr15:76604113 ETFA -0.46 -7.36 -0.37 1.43e-12 Blood metabolite levels; LUSC cis rs1577917 1.000 rs10944161 chr6:86630376 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC cis rs6942756 1.000 rs66864889 chr7:128952560 G/A cg02491457 chr7:128862824 NA -0.48 -6.68 -0.34 9.93e-11 White matter hyperintensity burden; LUSC cis rs9788682 1.000 rs7181245 chr15:78814389 C/T cg24631222 chr15:78858424 CHRNA5 0.83 11.48 0.53 5.98e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs225245 0.817 rs12150359 chr17:34024584 C/T cg05299278 chr17:33885742 SLFN14 0.3 6.62 0.34 1.43e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7107174 1.000 rs10899469 chr11:78018313 T/C cg02023728 chr11:77925099 USP35 0.48 6.76 0.35 6.33e-11 Testicular germ cell tumor; LUSC cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.955 rs4145951 chr4:120155817 A/G cg25214090 chr10:38739885 LOC399744 0.45 6.6 0.34 1.61e-10 Corneal astigmatism; LUSC trans rs8105895 0.825 rs62112369 chr19:22313901 C/T cg05197062 chr11:11642011 GALNTL4 -0.48 -5.97 -0.31 6.03e-9 Body mass index (change over time); LUSC trans rs1814175 0.935 rs11040438 chr11:49622521 G/A cg15704280 chr7:45808275 SEPT13 -1.08 -21.69 -0.76 1e-65 Height; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg24846343 chr22:24311635 DDTL 0.78 17.87 0.7 1.41e-50 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7215564 0.908 rs4243240 chr17:78660342 T/C cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg17366294 chr4:99064904 C4orf37 0.6 10.73 0.51 2.76e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg27279351 chr12:120934652 DYNLL1 0.63 8.41 0.42 1.21e-15 High light scatter reticulocyte count; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg21652505 chr19:40023540 EID2B 0.41 6.15 0.32 2.25e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs6700559 0.740 rs4437908 chr1:200648439 A/G cg07804481 chr1:200639085 DDX59 0.41 5.77 0.3 1.85e-8 Coronary artery disease; LUSC cis rs79149102 0.737 rs16973172 chr15:75156944 G/A cg09165964 chr15:75287851 SCAMP5 -0.89 -6.46 -0.33 3.72e-10 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07205460 chr22:24236375 MIF -0.42 -6.4 -0.33 5.32e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg06112835 chr11:68658793 MRPL21 0.48 7.4 0.38 1.09e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg10556349 chr10:835070 NA 0.57 6.38 0.33 5.77e-10 Eosinophil percentage of granulocytes; LUSC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg03161606 chr19:29218774 NA 0.64 9.82 0.47 3.67e-20 Methadone dose in opioid dependence; LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 6.93 0.35 2.12e-11 Bipolar disorder; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg00945038 chr17:61921165 SMARCD2 -0.53 -9.28 -0.45 2.2e-18 Prudent dietary pattern; LUSC cis rs2980439 0.556 rs2921059 chr8:8317887 G/T cg11608241 chr8:8085544 FLJ10661 0.42 6.27 0.32 1.14e-9 Neuroticism; LUSC cis rs8017423 0.647 rs11623736 chr14:90746471 G/T cg04374321 chr14:90722782 PSMC1 -0.68 -10.17 -0.49 2.42e-21 Mortality in heart failure; LUSC cis rs6840360 0.571 rs28608620 chr4:152504791 C/T cg22705602 chr4:152727874 NA -0.33 -6.66 -0.34 1.1e-10 Intelligence (multi-trait analysis); LUSC cis rs3857536 0.776 rs9294687 chr6:66942919 C/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.73 0.35 7.27e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6460942 0.908 rs6978877 chr7:12232690 A/G cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg00484396 chr16:3507460 NAT15 0.51 7.09 0.36 7.95e-12 Body mass index (adult); LUSC cis rs1670533 0.746 rs688008 chr4:1082829 T/C cg02018176 chr4:1364513 KIAA1530 0.45 6.34 0.33 7.29e-10 Recombination rate (females); LUSC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.89 12.1 0.55 3.42e-28 Smoking behavior; LUSC cis rs477692 1.000 rs516704 chr10:131419879 G/A cg05714579 chr10:131428358 MGMT 0.5 7.56 0.38 3.97e-13 Response to temozolomide; LUSC cis rs1028488 0.511 rs7738313 chr6:170704356 C/A cg20370364 chr6:170703943 FAM120B -0.49 -7.33 -0.37 1.77e-12 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs4363385 0.818 rs423692 chr1:153005681 T/G cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs4478858 0.735 rs2889730 chr1:31827159 C/T cg00250761 chr1:31883323 NA -0.36 -8.64 -0.43 2.28e-16 Alcohol dependence; LUSC cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.99 0.36 1.52e-11 Rheumatoid arthritis; LUSC cis rs7582180 0.676 rs6542940 chr2:100982144 A/T cg12002119 chr2:101014098 CHST10 0.35 5.96 0.31 6.41e-9 Intelligence (multi-trait analysis); LUSC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.61 0.38 2.81e-13 Bipolar disorder; LUSC trans rs225245 0.817 rs225297 chr17:33924587 G/A cg19694781 chr19:47549865 TMEM160 -0.41 -6.61 -0.34 1.51e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs4595586 0.545 rs4411311 chr12:39363612 C/G cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC cis rs11640436 0.544 rs12921392 chr16:77320605 C/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.39 -6.28 -0.33 1.03e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs10876993 0.928 rs1689587 chr12:58075398 A/G cg18357645 chr12:58087776 OS9 0.58 8.67 0.43 1.94e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs6700896 0.966 rs7516341 chr1:66088143 T/C cg04111102 chr1:66153794 NA 0.32 7.03 0.36 1.14e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3741151 0.572 rs12290623 chr11:73121872 C/G cg17517138 chr11:73019481 ARHGEF17 0.81 7.45 0.38 8.18e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7100689 0.646 rs7894762 chr10:82086779 C/G cg00277334 chr10:82204260 NA -0.58 -8.71 -0.43 1.47e-16 Post bronchodilator FEV1; LUSC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg06740227 chr12:86229804 RASSF9 0.43 6.76 0.35 6.18e-11 Major depressive disorder; LUSC cis rs72960926 0.744 rs6923498 chr6:74913523 C/T cg03266952 chr6:74778945 NA -0.67 -5.92 -0.31 8.1e-9 Metabolite levels (MHPG); LUSC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg09904177 chr6:26538194 HMGN4 -0.48 -5.94 -0.31 7.23e-9 Intelligence (multi-trait analysis); LUSC cis rs6445797 0.632 rs114096928 chr3:56637772 C/T cg13792233 chr3:56591045 CCDC66 0.4 5.68 0.3 2.98e-8 Gastritis; LUSC cis rs10207060 0.500 rs1316923 chr2:240719792 A/G cg07506560 chr2:240697449 NA -0.39 -6.1 -0.32 2.99e-9 Obesity-related traits; LUSC cis rs10751667 0.666 rs7396509 chr11:956761 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.13e-10 Alzheimer's disease (late onset); LUSC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg05585544 chr11:47624801 NA -0.41 -7.22 -0.37 3.44e-12 Subjective well-being; LUSC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg19774624 chr17:42201019 HDAC5 -0.8 -12.48 -0.56 1.39e-29 Total body bone mineral density; LUSC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.86 -0.4 5.4e-14 Blood metabolite levels; LUSC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs469568 0.901 rs338874 chr5:178668964 G/C cg08999896 chr5:178685787 ADAMTS2 0.29 6.13 0.32 2.46e-9 Stroke (pediatric); LUSC cis rs10876993 0.855 rs1689585 chr12:58080140 A/G cg15848620 chr12:58087721 OS9 0.56 8.09 0.4 1.14e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs72772090 0.539 rs11743410 chr5:96124453 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.96 -0.36 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs17030434 1.000 rs79094565 chr4:154718997 T/C cg14289246 chr4:154710475 SFRP2 -0.53 -6.84 -0.35 3.69e-11 Electrocardiographic conduction measures; LUSC cis rs7189233 0.955 rs8054299 chr16:53498655 C/G cg09728985 chr16:53543985 NA 0.33 5.75 0.3 2.03e-8 Intelligence (multi-trait analysis); LUSC cis rs2639990 1.000 rs1702831 chr18:72897368 C/A cg18449964 chr18:72917101 ZADH2 0.45 5.66 0.3 3.21e-8 Vascular endothelial growth factor levels; LUSC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg07493874 chr5:1342172 CLPTM1L 0.28 5.91 0.31 8.58e-9 Lung cancer; LUSC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg12963246 chr6:28129442 ZNF389 0.53 7.43 0.38 9.21e-13 Parkinson's disease; LUSC cis rs7937682 1.000 rs11213980 chr11:111562692 A/T cg22437258 chr11:111473054 SIK2 -0.43 -5.67 -0.3 3.09e-8 Primary sclerosing cholangitis; LUSC cis rs6066835 0.867 rs11698171 chr20:47359645 A/G cg18078177 chr20:47281410 PREX1 0.65 5.78 0.3 1.71e-8 Multiple myeloma; LUSC trans rs11700980 0.551 rs2832036 chr21:30115170 T/G cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg13770153 chr20:60521292 NA -0.58 -7.7 -0.39 1.56e-13 Body mass index; LUSC cis rs6681460 1.000 rs4655647 chr1:67106077 C/G cg02459107 chr1:67143332 SGIP1 0.47 8.68 0.43 1.82e-16 Presence of antiphospholipid antibodies; LUSC cis rs9815354 0.812 rs17216919 chr3:41888938 G/C cg03022575 chr3:42003672 ULK4 0.84 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7104764 0.507 rs6598054 chr11:254010 C/T cg00562011 chr11:252351 PSMD13 0.49 6.19 0.32 1.8e-9 Menarche (age at onset); LUSC cis rs7954584 0.611 rs3887885 chr12:122336486 C/T cg21171335 chr12:122356390 WDR66 0.59 9.02 0.44 1.55e-17 Mean corpuscular volume; LUSC cis rs6138458 1.000 rs6138458 chr20:24973769 C/T cg06937882 chr20:24974362 C20orf3 -0.45 -7.86 -0.4 5.32e-14 Blood protein levels; LUSC cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg24130564 chr14:104152367 KLC1 -0.42 -6.05 -0.31 3.79e-9 Body mass index; LUSC cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.6 9.19 0.45 4.42e-18 Menarche (age at onset); LUSC cis rs10788264 0.504 rs4751886 chr10:124020396 T/C cg09507567 chr10:124027408 NA 0.55 9.76 0.47 5.62e-20 Total body bone mineral density; LUSC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg16524733 chr11:117070046 TAGLN 0.43 7.48 0.38 6.56e-13 Blood protein levels; LUSC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg06618935 chr21:46677482 NA -0.39 -7.78 -0.39 9.05e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg14298792 chr15:30685198 CHRFAM7A 0.47 6.08 0.32 3.25e-9 Huntington's disease progression; LUSC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg09491104 chr22:46646882 C22orf40 -0.65 -6.9 -0.35 2.55e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.78 0.39 9.25e-14 Colorectal cancer; LUSC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg10130564 chr11:117069849 TAGLN 0.4 6.99 0.36 1.53e-11 Blood protein levels; LUSC cis rs7615316 0.934 rs7647573 chr3:142251583 C/T cg16271453 chr3:142027066 XRN1 -0.4 -6.83 -0.35 3.93e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs637571 0.522 rs679581 chr11:65746653 A/G cg17712092 chr4:129076599 LARP1B 0.73 11.12 0.52 1.19e-24 Eosinophil percentage of white cells; LUSC cis rs3820928 0.904 rs2396432 chr2:227765891 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.76 -0.39 1.07e-13 Pulmonary function; LUSC cis rs11229555 1.000 rs11603890 chr11:58402251 T/C cg15696309 chr11:58395628 NA -0.7 -9.28 -0.45 2.12e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7771547 0.573 rs619011 chr6:36476592 A/G cg07856975 chr6:36356162 ETV7 0.37 6.61 0.34 1.49e-10 Platelet distribution width; LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg14159672 chr1:205819179 PM20D1 0.47 6.71 0.34 8.19e-11 Prostate-specific antigen levels; LUSC cis rs12532214 0.690 rs6971710 chr7:3140173 G/A cg19214707 chr7:3157722 NA -0.38 -5.84 -0.3 1.24e-8 Itch intensity from mosquito bite; LUSC trans rs7829975 0.514 rs2976929 chr8:8258712 T/C cg21775007 chr8:11205619 TDH 0.42 6.14 0.32 2.32e-9 Mood instability; LUSC cis rs61931739 0.500 rs10844863 chr12:34532284 C/T cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs9905704 0.589 rs2632509 chr17:56487887 C/T cg12560992 chr17:57184187 TRIM37 -0.48 -5.77 -0.3 1.85e-8 Testicular germ cell tumor; LUSC cis rs709400 0.663 rs62007718 chr14:103940436 G/A cg24130564 chr14:104152367 KLC1 -0.41 -5.86 -0.31 1.12e-8 Body mass index; LUSC cis rs1215050 0.791 rs783960 chr4:98893437 A/G cg05340658 chr4:99064831 C4orf37 -0.43 -6.82 -0.35 4.3e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11644478 chr21:40555479 PSMG1 0.95 18.8 0.72 2.6e-54 Cognitive function; LUSC trans rs3857536 0.741 rs9363558 chr6:66937260 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs7106204 0.534 rs16912285 chr11:24252528 A/G ch.11.24196551F chr11:24239977 NA 0.72 6.09 0.32 3.05e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg12863693 chr15:85201151 NMB 0.34 6.24 0.32 1.36e-9 Schizophrenia; LUSC cis rs9300255 0.722 rs28458312 chr12:123863265 G/T cg13010344 chr12:123464640 ARL6IP4 0.51 6.5 0.33 2.97e-10 Neutrophil percentage of white cells; LUSC cis rs7674212 0.531 rs7665026 chr4:103936648 T/C cg16532752 chr4:104119610 CENPE -0.42 -5.78 -0.3 1.69e-8 Type 2 diabetes; LUSC cis rs1003719 0.788 rs60447195 chr21:38448600 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.42 0.53 9.82e-26 Eye color traits; LUSC cis rs7089973 0.604 rs61596353 chr10:116597763 T/C cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.23e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg02187348 chr16:89574699 SPG7 0.47 7.39 0.37 1.2e-12 Multiple myeloma (IgH translocation); LUSC cis rs4845459 0.967 rs4845446 chr1:152590750 C/T cg08895932 chr1:152778580 LCE1C 0.37 6.44 0.33 4.2e-10 Psoriasis; LUSC cis rs2346177 0.638 rs34186951 chr2:46657659 A/G cg02822958 chr2:46747628 ATP6V1E2 0.41 7.07 0.36 9.12e-12 HDL cholesterol; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg09040699 chr11:8009242 EIF3F 0.37 6.17 0.32 2e-9 Tuberculosis; LUSC cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg26384229 chr12:38710491 ALG10B 0.87 14.76 0.63 2.57e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs12286929 0.577 rs7101437 chr11:115063641 A/G cg04055981 chr11:115044050 NA -0.4 -7.22 -0.37 3.53e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9300255 0.602 rs1402274 chr12:123686224 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.15 -0.32 2.19e-9 Neutrophil percentage of white cells; LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg22920501 chr2:26401640 FAM59B -0.8 -12.27 -0.56 8.04e-29 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.59 0.78 3.14e-69 Prudent dietary pattern; LUSC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.82 0.6 1.14e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg20887711 chr4:1340912 KIAA1530 0.53 8.61 0.43 2.97e-16 Longevity; LUSC trans rs9747201 1.000 rs4597372 chr17:80175444 G/A cg07393940 chr7:158741817 NA 0.51 8.0 0.4 2.07e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1559088 1.000 rs8106453 chr19:33557412 C/T cg03563238 chr19:33554763 RHPN2 -0.39 -6.16 -0.32 2.14e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs62458065 0.850 rs62458066 chr7:32464484 C/T cg00845942 chr12:64062724 DPY19L2 -0.54 -6.23 -0.32 1.38e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs3820928 0.874 rs4423583 chr2:227874957 A/G cg11843606 chr2:227700838 RHBDD1 0.53 7.48 0.38 6.83e-13 Pulmonary function; LUSC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg13010344 chr12:123464640 ARL6IP4 -0.49 -6.69 -0.34 9.46e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.56 0.65 1.98e-41 Platelet count; LUSC trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg15704280 chr7:45808275 SEPT13 0.89 12.91 0.58 3.35e-31 Coronary artery disease; LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10876993 0.928 rs2640631 chr12:58067532 A/T cg18357645 chr12:58087776 OS9 0.53 8.05 0.4 1.47e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs3806843 0.966 rs1030166 chr5:140185473 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2760061 0.626 rs596208 chr1:228117982 G/C cg18477163 chr1:228402036 OBSCN -0.56 -10.39 -0.49 4.2e-22 Diastolic blood pressure; LUSC trans rs6601327 0.641 rs4840437 chr8:9606264 C/T cg15556689 chr8:8085844 FLJ10661 -0.47 -6.46 -0.33 3.67e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg22800045 chr5:56110881 MAP3K1 -0.61 -8.48 -0.42 7.25e-16 Initial pursuit acceleration; LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg12564285 chr5:131593104 PDLIM4 0.46 8.86 0.44 4.87e-17 Blood metabolite levels; LUSC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.11 14.24 0.61 2.64e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg07507251 chr3:52567010 NT5DC2 0.35 6.7 0.34 8.79e-11 Bipolar disorder; LUSC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg21963583 chr11:68658836 MRPL21 0.56 8.54 0.42 4.94e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06911149 chr19:10613456 KEAP1 -0.4 -5.98 -0.31 5.79e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg13825663 chr2:96873994 STARD7 0.38 5.98 0.31 5.75e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg20476274 chr7:133979776 SLC35B4 0.86 15.96 0.66 5.29e-43 Mean platelet volume; LUSC trans rs61931739 0.534 rs1352206 chr12:34036668 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.77 0.51 2.06e-23 Morning vs. evening chronotype; LUSC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10779751 0.734 rs2748878 chr1:11129434 T/C cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs7937682 0.921 rs4534611 chr11:111440425 C/G cg09085632 chr11:111637200 PPP2R1B -0.95 -13.16 -0.58 3.67e-32 Primary sclerosing cholangitis; LUSC cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg04455712 chr21:45112962 RRP1B 0.45 8.46 0.42 8.54e-16 Mean corpuscular volume; LUSC cis rs6700896 0.931 rs1938498 chr1:66098653 T/C cg04111102 chr1:66153794 NA 0.32 7.08 0.36 8.57e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7511006 0.893 rs760743 chr22:50647375 C/T cg08875078 chr22:50639485 SELO 0.45 6.18 0.32 1.84e-9 Obesity-related traits; LUSC cis rs2274273 0.712 rs1002054 chr14:55528913 A/C cg04306507 chr14:55594613 LGALS3 0.49 10.73 0.51 2.75e-23 Protein biomarker; LUSC cis rs9650657 0.707 rs4593498 chr8:10655470 C/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.88 -0.31 1.01e-8 Neuroticism; LUSC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg21963583 chr11:68658836 MRPL21 0.56 8.44 0.42 9.71e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.57 7.34 0.37 1.68e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs11971779 0.648 rs6947309 chr7:139035830 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.32 0.33 8.48e-10 Diisocyanate-induced asthma; LUSC cis rs75920871 0.528 rs7930264 chr11:116870766 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.48 -0.33 3.26e-10 Subjective well-being; LUSC cis rs17253792 0.822 rs58569951 chr14:56152245 T/C cg01858014 chr14:56050164 KTN1 -0.73 -6.4 -0.33 5.12e-10 Putamen volume; LUSC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg02931644 chr1:25747376 RHCE 0.38 6.87 0.35 3.11e-11 Erythrocyte sedimentation rate; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg03354898 chr7:1950403 MAD1L1 -0.42 -8.51 -0.42 5.81e-16 Bipolar disorder and schizophrenia; LUSC cis rs2295359 0.892 rs56920441 chr1:67652012 A/G cg17031739 chr1:67600172 NA 0.45 7.02 0.36 1.27e-11 Psoriasis; LUSC cis rs921968 0.541 rs933995 chr2:219650718 G/A cg02176678 chr2:219576539 TTLL4 -0.57 -10.21 -0.49 1.77e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.59 -11.7 -0.54 1e-26 Monocyte percentage of white cells; LUSC cis rs4595586 0.545 rs3914596 chr12:39388538 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs6580649 0.824 rs1635534 chr12:48386553 A/G cg24011408 chr12:48396354 COL2A1 0.49 6.07 0.32 3.52e-9 Lung cancer; LUSC cis rs243505 0.732 rs10255478 chr7:148501985 C/G cg09806900 chr7:148480153 CUL1 0.58 8.43 0.42 1.08e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg22496380 chr5:211416 CCDC127 -0.7 -7.95 -0.4 2.97e-14 Breast cancer; LUSC cis rs7666738 0.609 rs28833816 chr4:98868866 T/C cg17366294 chr4:99064904 C4orf37 0.53 8.2 0.41 5.33e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg24110177 chr3:50126178 RBM5 -0.55 -8.98 -0.44 2e-17 Intelligence (multi-trait analysis); LUSC cis rs709400 0.663 rs7152202 chr14:103886757 A/G cg24130564 chr14:104152367 KLC1 -0.4 -5.69 -0.3 2.78e-8 Body mass index; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg12461364 chr10:12084985 UPF2 0.36 6.0 0.31 5.06e-9 Mosquito bite size; LUSC cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg03213289 chr20:61660250 NA 0.66 12.81 0.57 7.61e-31 Prostate cancer (SNP x SNP interaction); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25152348 chr22:50946712 NCAPH2;LMF2 -0.36 -6.63 -0.34 1.34e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg10018233 chr7:150070692 REPIN1 0.39 6.35 0.33 7.01e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs713477 0.901 rs7146306 chr14:55905853 C/T cg13175173 chr14:55914753 NA -0.32 -6.77 -0.35 5.7e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg24642439 chr20:33292090 TP53INP2 0.7 11.16 0.52 8.54e-25 Coronary artery disease; LUSC cis rs9517320 0.515 rs4772099 chr13:99196121 A/C cg20487152 chr13:99095054 FARP1 -0.42 -7.15 -0.36 5.42e-12 Longevity; LUSC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg23283495 chr1:209979779 IRF6 0.73 9.34 0.46 1.37e-18 Cleft lip with or without cleft palate; LUSC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg11812906 chr14:75593930 NEK9 0.67 11.51 0.53 4.89e-26 Height; LUSC trans rs2290416 0.584 rs3816477 chr8:144685271 T/C cg08017606 chr5:145316274 SH3RF2 -0.58 -6.04 -0.31 4.11e-9 Attention deficit hyperactivity disorder; LUSC cis rs1538970 0.962 rs3219463 chr1:45806432 C/T cg05343316 chr1:45956843 TESK2 0.58 7.77 0.39 1.01e-13 Platelet count; LUSC cis rs394563 0.663 rs415434 chr6:149772645 A/G cg03678062 chr6:149772716 ZC3H12D -0.34 -7.16 -0.36 5.08e-12 Dupuytren's disease; LUSC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.85 0.31 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs17818399 0.547 rs7607633 chr2:46759427 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.55 -7.22 -0.37 3.57e-12 Height; LUSC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs1443512 0.812 rs1867299 chr12:54329975 T/C cg17410650 chr12:54324560 NA -0.59 -10.58 -0.5 9.56e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg03806693 chr22:41940476 POLR3H 1.0 14.26 0.62 2.35e-36 Vitiligo; LUSC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg16524733 chr11:117070046 TAGLN 0.44 7.73 0.39 1.29e-13 Blood protein levels; LUSC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg06238570 chr21:40685208 BRWD1 -0.65 -10.63 -0.5 6.1e-23 Cognitive function; LUSC cis rs7804356 1.000 rs55739485 chr7:26860741 T/C cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs2857891 0.817 rs2857901 chr11:6980511 A/G cg04053776 chr11:6947353 ZNF215 0.41 5.69 0.3 2.73e-8 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs853679 0.546 rs200989 chr6:27816442 A/G cg06606381 chr12:133084897 FBRSL1 -0.82 -7.93 -0.4 3.36e-14 Depression; LUSC cis rs7615952 0.551 rs6438945 chr3:125634473 G/A cg05084668 chr3:125655381 ALG1L -0.8 -11.75 -0.54 6.33e-27 Blood pressure (smoking interaction); LUSC cis rs12986413 0.651 rs2238610 chr19:2146852 T/C cg09261902 chr19:2140048 AP3D1 0.34 6.07 0.32 3.48e-9 Height; LUSC cis rs10484885 0.887 rs17707738 chr6:90602735 G/A cg13799429 chr6:90582589 CASP8AP2 -0.78 -8.4 -0.42 1.31e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9807989 0.839 rs10182710 chr2:102981306 A/G cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs7107174 0.892 rs11237450 chr11:78023356 C/A cg02023728 chr11:77925099 USP35 0.48 6.71 0.34 8.31e-11 Testicular germ cell tumor; LUSC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg09034736 chr1:150693464 HORMAD1 0.44 6.02 0.31 4.65e-9 Melanoma; LUSC cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg16339924 chr4:17578868 LAP3 -0.63 -9.72 -0.47 7.72e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -9.64 -0.47 1.4e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs950169 0.580 rs1061737 chr15:85183790 G/C cg17173187 chr15:85201210 NMB 0.46 8.73 0.43 1.26e-16 Schizophrenia; LUSC cis rs453301 0.653 rs7853 chr8:8890814 A/G cg08975724 chr8:8085496 FLJ10661 0.45 6.44 0.33 4.18e-10 Joint mobility (Beighton score); LUSC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg02569458 chr12:86230093 RASSF9 0.52 8.64 0.43 2.29e-16 Major depressive disorder; LUSC cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg01689657 chr7:91764605 CYP51A1 -0.32 -5.81 -0.3 1.47e-8 Breast cancer; LUSC cis rs1904096 0.506 rs10034781 chr4:95169682 A/C cg11021082 chr4:95130006 SMARCAD1 0.42 7.62 0.38 2.64e-13 Type 2 diabetes; LUSC cis rs9322193 0.923 rs4870052 chr6:150161114 G/A cg07701084 chr6:150067640 NUP43 0.53 7.89 0.4 4.29e-14 Lung cancer; LUSC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg02753203 chr1:228287806 NA 0.69 12.32 0.56 5.24e-29 Diastolic blood pressure; LUSC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.45 0.42 9.2e-16 Melanoma; LUSC cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg21854759 chr1:92012499 NA 0.43 5.66 0.3 3.29e-8 Eosinophil percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16090273 chr5:149737303 TCOF1 -0.41 -6.01 -0.31 4.95e-9 Electrocardiographic conduction measures; LUSC cis rs877282 0.583 rs10904564 chr10:819459 C/G cg13775593 chr10:823151 NA 0.29 5.98 0.31 5.67e-9 Uric acid levels; LUSC cis rs1577917 0.958 rs12215265 chr6:86443969 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.84 -0.44 5.48e-17 Response to antipsychotic treatment; LUSC cis rs7923609 0.811 rs4746204 chr10:65328518 C/T cg01631684 chr10:65280961 REEP3 0.4 5.97 0.31 6.15e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs4363385 0.693 rs6668311 chr1:152964586 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.59 -0.38 3.28e-13 Inflammatory skin disease; LUSC cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg00945038 chr17:61921165 SMARCD2 0.54 9.34 0.46 1.38e-18 Prudent dietary pattern; LUSC cis rs950776 0.518 rs55690619 chr15:78833612 A/G cg06917634 chr15:78832804 PSMA4 -0.82 -14.55 -0.62 1.77e-37 Sudden cardiac arrest; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg24739457 chr1:205821442 NA 0.35 6.07 0.32 3.56e-9 Menarche (age at onset); LUSC cis rs7215564 0.818 rs1032130 chr17:78610636 A/G cg23238734 chr17:78661607 RPTOR -0.46 -6.13 -0.32 2.47e-9 Myopia (pathological); LUSC trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg15704280 chr7:45808275 SEPT13 -0.99 -17.48 -0.69 4.68e-49 Height; LUSC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg00339695 chr16:24857497 SLC5A11 -0.39 -6.84 -0.35 3.82e-11 Intelligence (multi-trait analysis); LUSC trans rs853679 0.769 rs7752608 chr6:28301195 A/G cg01620082 chr3:125678407 NA -0.69 -6.54 -0.34 2.33e-10 Depression; LUSC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg15534755 chr11:117069859 TAGLN 0.36 5.85 0.3 1.17e-8 Blood protein levels; LUSC cis rs4474465 1.000 rs11237508 chr11:78173297 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs2235649 0.746 rs113666107 chr16:1848642 C/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.46 -6.12 -0.32 2.65e-9 Blood metabolite levels; LUSC cis rs6599192 1 rs6599192 chr3:41992408 G/A cg03022575 chr3:42003672 ULK4 -0.51 -5.79 -0.3 1.64e-8 Multiple myeloma; LUSC cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg21535247 chr6:8435926 SLC35B3 0.6 9.14 0.45 6.03e-18 Motion sickness; LUSC cis rs10493773 1.000 rs7523292 chr1:86134992 A/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.43 -0.46 7.18e-19 Urate levels in overweight individuals; LUSC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.05 22.14 0.77 1.81e-67 Height; LUSC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg00132208 chr4:10120780 NA 0.36 5.69 0.3 2.82e-8 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4906332 1.000 rs28711288 chr14:103906126 T/C cg04998671 chr14:104000505 TRMT61A -0.45 -6.99 -0.36 1.46e-11 Coronary artery disease; LUSC cis rs9457247 1.000 rs421214 chr6:167396629 A/G cg25258033 chr6:167368657 RNASET2 0.47 7.84 0.39 6.02e-14 Crohn's disease; LUSC cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg24060327 chr5:131705240 SLC22A5 -0.51 -8.49 -0.42 6.9e-16 Breast cancer; LUSC cis rs68170813 0.617 rs10464499 chr7:107137571 C/T cg02696742 chr7:106810147 HBP1 -0.64 -8.62 -0.43 2.66e-16 Coronary artery disease; LUSC cis rs2970818 0.831 rs11063191 chr12:4588579 C/T cg11146114 chr12:4671731 NA -0.6 -5.69 -0.3 2.83e-8 Phosphorus levels; LUSC cis rs7746199 0.736 rs17693963 chr6:27710165 A/C cg26958806 chr6:27640298 NA 0.73 6.17 0.32 2.01e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg08680598 chr22:49984980 NA -0.34 -6.29 -0.33 1e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1865760 0.533 rs1408270 chr6:25873184 A/G cg17691542 chr6:26056736 HIST1H1C 0.52 7.07 0.36 9.05e-12 Height; LUSC cis rs738321 0.694 rs4821749 chr22:38542074 A/G cg25457927 chr22:38595422 NA -0.42 -8.01 -0.4 1.93e-14 Breast cancer; LUSC trans rs61931739 0.500 rs11053277 chr12:34553835 T/A cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.03 14.55 0.62 1.74e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg22508957 chr16:3507546 NAT15 0.84 10.69 0.5 3.89e-23 Tuberculosis; LUSC cis rs7674212 0.541 rs17217473 chr4:104114742 A/C cg16532752 chr4:104119610 CENPE -0.48 -6.82 -0.35 4.31e-11 Type 2 diabetes; LUSC cis rs4919687 0.550 rs4264100 chr10:104454113 C/G cg04362960 chr10:104952993 NT5C2 0.47 6.93 0.35 2.15e-11 Colorectal cancer; LUSC trans rs514406 0.929 rs12410420 chr1:53323754 T/C cg24643429 chr1:3562429 WDR8 0.33 6.05 0.31 3.88e-9 Monocyte count; LUSC cis rs77741769 0.571 rs11065292 chr12:121289155 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.51 0.42 5.9e-16 Mean corpuscular volume; LUSC cis rs950169 0.580 rs36126054 chr15:85177723 T/G cg17173187 chr15:85201210 NMB 0.46 8.73 0.43 1.26e-16 Schizophrenia; LUSC cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg13256891 chr4:100009986 ADH5 0.48 7.11 0.36 7.05e-12 Alcohol dependence; LUSC cis rs9611565 0.649 rs5751144 chr22:42128097 A/G cg17376030 chr22:41985996 PMM1 0.42 5.71 0.3 2.53e-8 Vitiligo; LUSC cis rs714027 0.566 rs1548389 chr22:30573552 T/C cg11564601 chr22:30592435 NA 0.32 5.67 0.3 3.03e-8 Lymphocyte counts; LUSC cis rs7666738 0.606 rs4699606 chr4:99095074 A/C cg17366294 chr4:99064904 C4orf37 -0.47 -7.64 -0.39 2.33e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7577851 0.716 rs72833929 chr2:69678853 T/C cg10773587 chr2:69614142 GFPT1 0.55 6.23 0.32 1.44e-9 Parkinson's disease (age of onset); LUSC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg27170947 chr2:26402098 FAM59B -0.62 -9.45 -0.46 6.1e-19 Gut microbiome composition (summer); LUSC cis rs9788682 0.747 rs8042059 chr15:78907859 A/C cg06917634 chr15:78832804 PSMA4 -0.48 -6.49 -0.33 3.02e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6690583 0.623 rs11588160 chr1:85444226 T/G cg11262906 chr1:85462892 MCOLN2 0.69 6.56 0.34 2.1e-10 Serum sulfate level; LUSC cis rs9814567 0.806 rs4519744 chr3:134321523 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.33 -0.56 4.74e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9399135 1.000 rs4895435 chr6:135293463 C/A cg24558204 chr6:135376177 HBS1L 0.57 8.58 0.43 3.55e-16 Red blood cell count; LUSC cis rs78545713 0.649 rs11753717 chr6:26220202 G/C cg23601095 chr6:26197514 HIST1H3D 0.66 5.79 0.3 1.64e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs929354 0.772 rs3802118 chr7:156986814 T/C cg17757837 chr7:157058334 UBE3C 0.83 13.33 0.59 8.46e-33 Body mass index; LUSC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.98 0.36 1.57e-11 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg08270630 chr22:50330655 NA 0.4 5.93 0.31 7.52e-9 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25377475 chr1:236030556 LYST -0.57 -6.73 -0.35 7.29e-11 Bipolar disorder and schizophrenia; LUSC cis rs1065852 0.526 rs9607869 chr22:42418110 T/A cg22189786 chr22:42395067 WBP2NL 0.43 5.76 0.3 1.91e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11357813 chr19:52693064 PPP2R1A -0.43 -6.44 -0.33 4.22e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17227506 0.704 rs66965169 chr8:13454056 C/T cg03566418 chr8:13424080 C8orf48 0.4 5.98 0.31 5.6e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs427941 0.655 rs2529095 chr7:101749663 C/T cg06246474 chr7:101738831 CUX1 0.39 6.33 0.33 8.12e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7568458 0.905 rs10198569 chr2:85794415 C/T cg17127132 chr2:85788382 GGCX -0.43 -6.73 -0.35 7.59e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs617791 0.508 rs1047464 chr11:65769456 A/T cg17712092 chr4:129076599 LARP1B -0.69 -9.72 -0.47 7.89e-20 Breast cancer; LUSC trans rs7618501 0.633 rs6772095 chr3:49978069 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 9.47 0.46 5.4e-19 Intelligence (multi-trait analysis); LUSC cis rs3824867 0.920 rs9734013 chr11:47451517 G/T cg20307385 chr11:47447363 PSMC3 -0.64 -9.52 -0.46 3.67e-19 Mean corpuscular hemoglobin; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg02037503 chr14:23540729 ACIN1 0.53 6.44 0.33 4.24e-10 Cognitive function;Information processing speed; LUSC cis rs7789940 0.951 rs7787526 chr7:75947553 C/T cg10167463 chr7:75959203 YWHAG -0.63 -9.35 -0.46 1.26e-18 Multiple sclerosis; LUSC cis rs7208859 0.623 rs9912283 chr17:29110373 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7582180 0.675 rs4851313 chr2:101029002 A/G cg12002119 chr2:101014098 CHST10 -0.37 -6.31 -0.33 8.67e-10 Intelligence (multi-trait analysis); LUSC cis rs34638657 0.732 rs62045963 chr16:82200661 A/G cg09439754 chr16:82129088 HSD17B2 -0.39 -6.31 -0.33 8.83e-10 Lung adenocarcinoma; LUSC trans rs6499188 0.522 rs10153230 chr16:68671741 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.6 8.16 0.41 6.69e-15 Ulcerative colitis; LUSC cis rs713587 0.935 rs11676272 chr2:25141538 A/G cg01884057 chr2:25150051 NA 0.5 11.78 0.54 4.96e-27 Body mass index in non-asthmatics; LUSC trans rs11098499 0.913 rs56122576 chr4:120129336 A/G cg25214090 chr10:38739885 LOC399744 0.45 6.42 0.33 4.79e-10 Corneal astigmatism; LUSC trans rs702885 0.655 rs702911 chr2:65767902 T/C cg06379192 chr1:3157287 PRDM16 -0.73 -6.18 -0.32 1.92e-9 Electroencephalogram traits; LUSC cis rs3768617 0.510 rs4652776 chr1:183091920 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.94 0.51 4.97e-24 Fuchs's corneal dystrophy; LUSC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg11845111 chr2:191398756 TMEM194B 0.55 9.43 0.46 6.96e-19 Pulse pressure; LUSC cis rs6599077 1.000 rs9832726 chr3:40097576 C/G cg13683864 chr3:40499215 RPL14 -0.62 -7.54 -0.38 4.57e-13 Sleep-related phenotypes; LUSC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg03709012 chr19:19516395 GATAD2A -0.83 -14.22 -0.61 3.2e-36 Tonsillectomy; LUSC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9658691 0.607 rs9658766 chr10:90771612 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -6.17 -0.32 1.95e-9 Mosquito bite size; LUSC cis rs9300255 0.544 rs2049114 chr12:123657338 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.94e-9 Neutrophil percentage of white cells; LUSC cis rs9527 0.641 rs34130454 chr10:104903638 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg02581963 chr10:102133317 C10orf75 0.38 6.32 0.33 8.54e-10 Calcium levels; LUSC cis rs977987 0.806 rs2285225 chr16:75429252 T/C cg03315344 chr16:75512273 CHST6 0.49 9.22 0.45 3.5e-18 Dupuytren's disease; LUSC cis rs1801251 1.000 rs2044449 chr2:233718808 G/A cg08000102 chr2:233561755 GIGYF2 -0.69 -11.63 -0.54 1.75e-26 Coronary artery disease; LUSC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg16405210 chr4:1374714 KIAA1530 -0.53 -8.02 -0.4 1.84e-14 Obesity-related traits; LUSC cis rs7851660 0.967 rs7043885 chr9:100596439 C/T cg13688889 chr9:100608707 NA -0.6 -10.04 -0.48 6.78e-21 Strep throat; LUSC cis rs10740039 1.000 rs6479723 chr10:62417885 T/C cg18175470 chr10:62150864 ANK3 -0.43 -6.79 -0.35 5.23e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg04553112 chr3:125709451 NA -0.5 -5.68 -0.3 2.9e-8 Blood pressure (smoking interaction); LUSC trans rs6502050 0.769 rs11658272 chr17:80084596 C/T cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg11764359 chr7:65958608 NA 0.71 10.66 0.5 5.06e-23 Aortic root size; LUSC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg19678392 chr7:94953810 PON1 -0.36 -5.65 -0.3 3.47e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs34779708 0.931 rs34304999 chr10:35365705 C/T cg03585969 chr10:35415529 CREM 0.59 8.58 0.42 3.65e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg05585544 chr11:47624801 NA 0.41 7.12 0.36 6.53e-12 Subjective well-being; LUSC cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg08807101 chr21:30365312 RNF160 -0.75 -13.33 -0.59 8.42e-33 Dental caries; LUSC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg08270630 chr22:50330655 NA 0.4 5.93 0.31 7.52e-9 Schizophrenia; LUSC cis rs7927771 0.524 rs9633830 chr11:47849470 T/G cg20307385 chr11:47447363 PSMC3 0.45 6.52 0.34 2.68e-10 Subjective well-being; LUSC trans rs1459104 0.925 rs34666788 chr11:55138501 T/A cg15704280 chr7:45808275 SEPT13 0.74 6.06 0.31 3.78e-9 Body mass index; LUSC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg25072359 chr17:41440525 NA 0.66 9.54 0.46 3.2e-19 Menopause (age at onset); LUSC trans rs877282 1.000 rs12763443 chr10:771941 G/A cg13042288 chr15:90349979 ANPEP -0.49 -6.92 -0.35 2.31e-11 Uric acid levels; LUSC cis rs17685 0.593 rs56265719 chr7:75796269 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.79 -0.39 8.8e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs3749237 1.000 rs11717256 chr3:49868520 C/T cg03060546 chr3:49711283 APEH 0.56 8.06 0.4 1.36e-14 Resting heart rate; LUSC cis rs7917772 0.582 rs729024 chr10:104341975 T/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7584330 0.780 rs12474519 chr2:238377012 G/A cg14458575 chr2:238380390 NA 0.68 11.77 0.54 5.35e-27 Prostate cancer; LUSC cis rs79349575 0.756 rs937301 chr17:47046276 A/G cg22482690 chr17:47019901 SNF8 -0.37 -6.98 -0.36 1.63e-11 Type 2 diabetes; LUSC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.72 0.47 7.61e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4631830 0.863 rs2611507 chr10:51518673 T/C cg20129853 chr10:51489980 NA -0.33 -6.63 -0.34 1.36e-10 Prostate-specific antigen levels; LUSC cis rs314370 0.818 rs12705091 chr7:100472380 C/T cg10426581 chr7:100472382 SRRT 0.8 11.26 0.52 3.73e-25 Resting heart rate; LUSC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg22437258 chr11:111473054 SIK2 0.53 7.53 0.38 4.93e-13 Primary sclerosing cholangitis; LUSC cis rs66887589 0.616 rs10032299 chr4:120206419 C/T cg24375607 chr4:120327624 NA 0.49 7.56 0.38 3.9e-13 Diastolic blood pressure; LUSC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg04317338 chr11:64019027 PLCB3 0.68 7.65 0.39 2.23e-13 Mean platelet volume; LUSC cis rs3096299 0.900 rs4785663 chr16:89434888 G/A cg00750074 chr16:89608354 SPG7 -0.44 -7.46 -0.38 7.64e-13 Multiple myeloma (IgH translocation); LUSC cis rs9400467 0.528 rs11153290 chr6:111718132 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.98 -0.36 1.57e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg07677032 chr17:61819896 STRADA 0.55 8.97 0.44 2.1e-17 Prudent dietary pattern; LUSC cis rs2046867 0.862 rs6778168 chr3:72840206 T/A cg25664220 chr3:72788482 NA -0.67 -11.67 -0.54 1.29e-26 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7043114 0.525 rs4744136 chr9:95275024 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.4 7.09 0.36 8.02e-12 Height; LUSC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.67 8.69 0.43 1.71e-16 Schizophrenia; LUSC trans rs4332037 0.624 rs73046339 chr7:1889300 G/A cg11693508 chr17:37793320 STARD3 0.5 6.29 0.33 1e-9 Bipolar disorder; LUSC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg11843238 chr5:131593191 PDLIM4 0.37 6.33 0.33 7.93e-10 Breast cancer; LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg11218175 chr11:495084 RNH1 0.53 5.69 0.3 2.84e-8 Body mass index; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.87 0.4 5.04e-14 Prudent dietary pattern; LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg18538332 chr22:24372958 LOC391322 -0.37 -6.71 -0.34 8.28e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg22535103 chr8:58192502 C8orf71 -0.73 -7.66 -0.39 2.06e-13 Developmental language disorder (linguistic errors); LUSC trans rs7395662 0.591 rs12807777 chr11:48593754 A/T cg15704280 chr7:45808275 SEPT13 -0.45 -6.22 -0.32 1.49e-9 HDL cholesterol; LUSC cis rs1595825 0.891 rs2045244 chr2:198506466 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis; LUSC trans rs12902680 0.618 rs12439798 chr15:46584787 G/T cg04321580 chr8:143696133 ARC -0.41 -6.13 -0.32 2.49e-9 Neuroticism; LUSC cis rs7616215 0.519 rs2133664 chr3:46101774 T/A cg08033130 chr3:45983597 CXCR6;FYCO1 0.37 6.3 0.33 9.44e-10 Behcet's disease; LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs4409675 0.576 rs6700473 chr1:28236682 C/T cg23691781 chr1:28212827 C1orf38 0.29 6.6 0.34 1.62e-10 Corneal astigmatism; LUSC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg00149659 chr3:10157352 C3orf10 -0.61 -7.85 -0.39 5.87e-14 Alzheimer's disease; LUSC cis rs6076065 0.748 rs4815198 chr20:23343491 T/C cg11657817 chr20:23433608 CST11 0.56 11.41 0.53 1.06e-25 Facial morphology (factor 15, philtrum width); LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.94 0.48 1.4e-20 Bipolar disorder; LUSC cis rs4268898 0.722 rs4665253 chr2:24382546 G/A cg06627628 chr2:24431161 ITSN2 0.54 7.47 0.38 7.13e-13 Asthma; LUSC cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.46 -6.51 -0.34 2.79e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs1325195 0.920 rs9727252 chr1:179089518 C/G cg11624085 chr17:8464688 MYH10 -0.45 -7.39 -0.37 1.16e-12 IgE grass sensitization; LUSC cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg06808227 chr14:105710500 BRF1 -0.63 -9.63 -0.47 1.54e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs10761482 0.500 rs2153525 chr10:62269574 G/T cg18175470 chr10:62150864 ANK3 0.47 6.66 0.34 1.11e-10 Schizophrenia; LUSC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg21699342 chr2:239360505 ASB1 -0.56 -10.56 -0.5 1.07e-22 Multiple system atrophy; LUSC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg07424592 chr7:64974309 NA 0.7 6.05 0.31 3.99e-9 Diabetic kidney disease; LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.687 rs1470531 chr6:86507369 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.76 -0.43 9.98e-17 Response to antipsychotic treatment; LUSC trans rs1005277 0.579 rs2474572 chr10:38385316 A/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.52 -0.46 3.61e-19 Extrinsic epigenetic age acceleration; LUSC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg05890377 chr2:74357713 NA 0.73 13.5 0.59 1.99e-33 Gestational age at birth (maternal effect); LUSC cis rs886126 1.000 rs7973104 chr12:111670774 C/G cg10833066 chr12:111807467 FAM109A 0.38 6.16 0.32 2.14e-9 Coronary heart disease; LUSC cis rs807669 0.807 rs712948 chr22:19206499 A/G cg02655711 chr22:19163373 SLC25A1 0.9 17.05 0.68 2.45e-47 Metabolite levels; LUSC cis rs2404602 0.735 rs2048856 chr15:76800083 C/T cg23625390 chr15:77176239 SCAPER -0.54 -8.26 -0.41 3.44e-15 Blood metabolite levels; LUSC cis rs4561483 0.801 rs33631 chr16:11995387 G/C cg08843971 chr16:11963173 GSPT1 -0.45 -6.6 -0.34 1.61e-10 Testicular germ cell tumor; LUSC cis rs2637266 1.000 rs2637268 chr10:78332213 G/T cg18941641 chr10:78392320 NA 0.37 6.58 0.34 1.84e-10 Pulmonary function; LUSC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg08859206 chr1:53392774 SCP2 -0.43 -7.04 -0.36 1.09e-11 Monocyte count; LUSC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg09033563 chr22:24373618 LOC391322 -0.53 -7.99 -0.4 2.27e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs714027 1.000 rs4823075 chr22:30519152 T/C cg11564601 chr22:30592435 NA -0.37 -6.78 -0.35 5.4e-11 Lymphocyte counts; LUSC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.83 -0.54 3.43e-27 Schizophrenia; LUSC cis rs11583043 0.918 rs17525451 chr1:101422409 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.2 0.32 1.71e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs12701220 0.596 rs10274383 chr7:1002013 T/C cg26769984 chr7:1090371 C7orf50 0.44 6.27 0.32 1.13e-9 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.88 -0.31 9.94e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs354225 0.544 rs7599241 chr2:54801856 G/A cg26097391 chr2:54893211 SPTBN1 0.46 6.92 0.35 2.38e-11 Schizophrenia; LUSC cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg05294307 chr14:35346193 BAZ1A -0.6 -7.05 -0.36 1.06e-11 Psoriasis; LUSC cis rs1801251 0.778 rs2250654 chr2:233752376 A/T cg08000102 chr2:233561755 GIGYF2 -0.5 -7.72 -0.39 1.35e-13 Coronary artery disease; LUSC cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg13175981 chr1:150552382 MCL1 0.43 6.06 0.31 3.71e-9 Tonsillectomy; LUSC cis rs9467711 0.606 rs67509210 chr6:26354100 G/T cg09904177 chr6:26538194 HMGN4 -0.7 -6.65 -0.34 1.17e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7937890 0.681 rs4756784 chr11:14270904 G/A cg05501817 chr11:14380813 RRAS2 0.44 6.21 0.32 1.56e-9 Mitochondrial DNA levels; LUSC cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg27432699 chr2:27873401 GPN1 -0.57 -8.53 -0.42 5.15e-16 Total body bone mineral density; LUSC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg10523679 chr1:76189770 ACADM 0.83 10.7 0.51 3.71e-23 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14240646 chr10:27532245 ACBD5 0.73 8.72 0.43 1.3e-16 Breast cancer; LUSC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg04248312 chr19:17393744 ANKLE1 0.98 16.68 0.67 7.26e-46 Systemic lupus erythematosus; LUSC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg24250549 chr1:154909240 PMVK 0.63 10.2 0.49 1.98e-21 Prostate cancer; LUSC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg00310523 chr12:86230176 RASSF9 0.49 9.26 0.45 2.64e-18 Major depressive disorder; LUSC cis rs8032315 1.000 rs6227 chr15:91425232 C/T cg04510874 chr15:91427884 FES 0.3 5.89 0.31 9.17e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9650315 0.789 rs13269647 chr8:57203809 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs34779708 0.931 rs11597483 chr10:35285117 A/G cg03585969 chr10:35415529 CREM 0.64 9.13 0.45 6.65e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs7267979 1.000 rs1047171 chr20:25428786 T/C cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg09796270 chr17:17721594 SREBF1 0.43 7.63 0.39 2.41e-13 Total body bone mineral density; LUSC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg06742321 chr12:123595122 PITPNM2 -0.39 -5.72 -0.3 2.36e-8 Neutrophil percentage of white cells; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.93e-29 Prudent dietary pattern; LUSC cis rs34779708 0.966 rs2045918 chr10:35418517 T/G cg03585969 chr10:35415529 CREM 0.61 8.97 0.44 2.24e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs71636778 0.596 rs2095637 chr1:27232845 A/G cg12203394 chr1:27248618 NUDC 0.54 5.71 0.3 2.52e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs11971779 0.650 rs10085842 chr7:139064582 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs870825 0.550 rs10000507 chr4:185619281 C/T cg04058563 chr4:185651563 MLF1IP 0.86 13.39 0.59 5.13e-33 Blood protein levels; LUSC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.17 -0.41 6.53e-15 Axial length; LUSC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg11247378 chr22:39784982 NA -0.65 -13.31 -0.59 9.7e-33 Intelligence (multi-trait analysis); LUSC cis rs8062405 0.755 rs4788078 chr16:28559981 G/A cg16576597 chr16:28551801 NUPR1 0.34 6.91 0.35 2.5e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs477692 1.000 rs553371 chr10:131413676 T/C cg05714579 chr10:131428358 MGMT 0.51 7.68 0.39 1.78e-13 Response to temozolomide; LUSC cis rs3849570 0.615 rs6778265 chr3:81985745 C/T cg07356753 chr3:81810745 GBE1 0.42 6.15 0.32 2.23e-9 Waist circumference;Body mass index; LUSC cis rs6546550 0.901 rs6736408 chr2:70137774 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs3796352 1.000 rs11712653 chr3:53070875 A/C cg12962167 chr3:53033115 SFMBT1 -0.58 -5.69 -0.3 2.81e-8 Immune reponse to smallpox (secreted IL-2); LUSC cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg00071950 chr4:10020882 SLC2A9 -0.48 -8.04 -0.4 1.6e-14 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03445127 chr3:101232168 SENP7 -0.45 -6.08 -0.32 3.32e-9 Hepatitis; LUSC cis rs977987 0.835 rs4888380 chr16:75347690 T/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.71 -0.34 8.56e-11 Dupuytren's disease; LUSC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg23262073 chr20:60523788 NA -0.42 -6.11 -0.32 2.7e-9 Body mass index; LUSC cis rs208515 0.525 rs1484577 chr6:66688397 A/G cg07460842 chr6:66804631 NA 1.03 14.32 0.62 1.35e-36 Exhaled nitric oxide levels; LUSC cis rs1044826 0.642 rs295478 chr3:139223135 G/A cg15131784 chr3:139108705 COPB2 0.39 6.34 0.33 7.33e-10 Obesity-related traits; LUSC cis rs2348418 0.864 rs6487687 chr12:28711163 A/C cg13890972 chr12:28721907 NA -0.36 -6.27 -0.32 1.14e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg14584255 chr6:163149320 PACRG;PARK2 -0.38 -7.48 -0.38 6.75e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg06505273 chr16:24850292 NA -0.41 -5.89 -0.31 9.18e-9 Intelligence (multi-trait analysis); LUSC cis rs4629180 0.675 rs10183203 chr2:102095080 C/T cg04415270 chr2:102091202 RFX8 0.45 7.78 0.39 9.3e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs11190604 1.000 rs10786596 chr10:102282126 C/A cg16342193 chr10:102329863 NA -0.34 -6.29 -0.33 9.9e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs354225 0.544 rs12713269 chr2:54809154 C/G cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs16976116 0.901 rs62020114 chr15:55501116 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6840360 1.000 rs6823194 chr4:152604543 T/C cg22705602 chr4:152727874 NA -0.28 -5.84 -0.3 1.22e-8 Intelligence (multi-trait analysis); LUSC trans rs3942852 0.869 rs4752806 chr11:48118199 G/C cg03929089 chr4:120376271 NA -0.54 -6.21 -0.32 1.56e-9 Acute lymphoblastic leukemia (childhood); LUSC trans rs1814175 0.935 rs7482690 chr11:49648814 C/T cg03929089 chr4:120376271 NA -0.99 -17.46 -0.69 5.58e-49 Height; LUSC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg02807482 chr3:125708958 NA -0.52 -6.49 -0.33 3.08e-10 Blood pressure (smoking interaction); LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg12084011 chr7:107220368 BCAP29 0.42 6.7 0.34 9e-11 Bladder cancer; LUSC cis rs6752107 1.000 rs35300242 chr2:234168790 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.72 11.96 0.55 1.11e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC cis rs28655083 1.000 rs7198870 chr16:77072963 C/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.38 -5.77 -0.3 1.83e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg10169327 chr19:45448959 APOC2 0.3 6.38 0.33 5.74e-10 Blood protein levels; LUSC cis rs1580019 0.885 rs3801331 chr7:32497039 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.81 -12.04 -0.55 5.6e-28 Cognitive ability; LUSC cis rs9611519 0.964 rs4820428 chr22:41537589 C/T cg03806693 chr22:41940476 POLR3H 0.52 7.27 0.37 2.62e-12 Neuroticism; LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.45 0.33 3.89e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7804356 1.000 rs17376018 chr7:26889862 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg01028140 chr2:1542097 TPO -0.6 -7.99 -0.4 2.16e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg10909506 chr17:38081995 ORMDL3 0.32 5.75 0.3 2.06e-8 Self-reported allergy; LUSC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg23625390 chr15:77176239 SCAPER 0.45 6.87 0.35 3.13e-11 Blood metabolite levels; LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg07212818 chr11:638076 DRD4 -0.44 -7.5 -0.38 5.65e-13 Systemic lupus erythematosus; LUSC cis rs72781680 0.898 rs10490752 chr2:24025132 C/T cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg07701084 chr6:150067640 NUP43 0.53 7.97 0.4 2.51e-14 Lung cancer; LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg27535305 chr1:53392650 SCP2 0.38 7.08 0.36 8.63e-12 Monocyte count; LUSC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg04414720 chr1:150670196 GOLPH3L 0.54 8.46 0.42 8.59e-16 Melanoma; LUSC trans rs7824557 0.585 rs2572385 chr8:11208903 G/A cg06636001 chr8:8085503 FLJ10661 0.55 7.93 0.4 3.24e-14 Retinal vascular caliber; LUSC cis rs9818941 1.000 rs7429574 chr3:157703589 G/A cg08654915 chr3:157813417 NA -0.24 -5.79 -0.3 1.59e-8 Height; LUSC cis rs753778 0.963 rs3739234 chr8:142229178 G/A cg18755752 chr8:142205143 DENND3 -0.51 -6.68 -0.34 1e-10 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4851254 0.618 rs7596359 chr2:100665274 T/G cg22139774 chr2:100720529 AFF3 -0.44 -5.81 -0.3 1.43e-8 Intelligence (multi-trait analysis); LUSC cis rs56235845 0.694 rs11738681 chr5:176761535 A/G cg16006841 chr5:176797999 RGS14 0.63 10.03 0.48 6.99e-21 Hemoglobin concentration;Hematocrit; LUSC cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg26384229 chr12:38710491 ALG10B 0.87 14.76 0.63 2.57e-38 Bladder cancer; LUSC trans rs62458065 0.640 rs4141788 chr7:32519264 T/C cg00845942 chr12:64062724 DPY19L2 -0.53 -6.29 -0.33 1.01e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.16 -0.32 2.1e-9 Bipolar disorder; LUSC cis rs62400317 0.859 rs62400293 chr6:45233580 A/T cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg00074818 chr8:8560427 CLDN23 0.6 9.86 0.47 2.72e-20 Obesity-related traits; LUSC cis rs3768617 0.510 rs10797843 chr1:183081995 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.85 0.51 1.05e-23 Fuchs's corneal dystrophy; LUSC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg18681998 chr4:17616180 MED28 0.92 18.35 0.71 1.66e-52 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg14440974 chr22:39074834 NA -0.35 -5.84 -0.3 1.23e-8 Menopause (age at onset); LUSC cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg23625390 chr15:77176239 SCAPER 0.54 8.48 0.42 7.12e-16 Blood metabolite levels; LUSC trans rs804280 0.518 rs34266352 chr8:11791462 G/A cg08975724 chr8:8085496 FLJ10661 0.5 7.16 0.36 5.12e-12 Myopia (pathological); LUSC cis rs7584330 0.737 rs12465714 chr2:238365637 C/T cg16989719 chr2:238392110 NA -0.41 -7.25 -0.37 3e-12 Prostate cancer; LUSC cis rs12122100 0.696 rs12752148 chr1:146557073 T/C cg03526459 chr1:146549940 NA -0.41 -6.45 -0.33 3.86e-10 HIV-1 control; LUSC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg03452623 chr4:187889614 NA -0.89 -18.54 -0.71 2.95e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs861020 0.677 rs12723578 chr1:210032392 G/A cg05527609 chr1:210001259 C1orf107 -1.04 -13.87 -0.6 7.08e-35 Orofacial clefts; LUSC cis rs2200578 0.841 rs116668293 chr2:99596991 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 0.63 7.53 0.38 4.78e-13 IgG glycosylation; LUSC cis rs2219968 1.000 rs1121552 chr8:78958699 T/G cg00738934 chr8:78996279 NA 0.34 6.19 0.32 1.81e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs10435719 0.638 rs67146188 chr8:11782433 A/G cg14343924 chr8:8086146 FLJ10661 -0.45 -6.23 -0.32 1.43e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg06462663 chr19:18546047 ISYNA1 0.46 7.91 0.4 3.7e-14 Breast cancer; LUSC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg03885332 chr11:832357 CD151 -0.35 -5.9 -0.31 8.82e-9 Mean platelet volume; LUSC cis rs35094601 0.731 rs34305589 chr2:139217803 T/C cg10095539 chr2:139258744 SPOPL 0.25 5.84 0.3 1.21e-8 Schizophrenia; LUSC cis rs4363385 0.818 rs2651413 chr1:153012068 T/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg12615879 chr12:58013172 SLC26A10 -0.29 -6.12 -0.32 2.62e-9 Multiple sclerosis; LUSC cis rs2970818 0.665 rs11063183 chr12:4583182 A/T cg11146114 chr12:4671731 NA -0.61 -5.77 -0.3 1.84e-8 Phosphorus levels; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.78 0.77 4.41e-66 Prudent dietary pattern; LUSC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg13628971 chr7:2884303 GNA12 0.39 5.79 0.3 1.64e-8 Height; LUSC cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg08999081 chr20:33150536 PIGU 0.37 6.74 0.35 6.92e-11 Height; LUSC cis rs61931739 0.517 rs10844815 chr12:34245150 G/A cg06521331 chr12:34319734 NA -0.47 -7.79 -0.39 8.61e-14 Morning vs. evening chronotype; LUSC cis rs7647973 1.000 rs62261249 chr3:49594060 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.52 -7.64 -0.39 2.34e-13 Menarche (age at onset); LUSC cis rs1018836 0.575 rs17635255 chr8:91518135 A/T cg16814680 chr8:91681699 NA -0.54 -7.1 -0.36 7.39e-12 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs3808502 0.585 rs4549730 chr8:11239078 T/G cg15556689 chr8:8085844 FLJ10661 -0.47 -7.29 -0.37 2.2e-12 Neuroticism; LUSC cis rs11758351 1.000 rs76329209 chr6:26196430 A/G cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg05425664 chr17:57184151 TRIM37 -0.52 -7.83 -0.39 6.51e-14 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg24581572 chr1:205197876 TMCC2 0.44 6.17 0.32 2.02e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs738322 0.804 rs2076116 chr22:38517405 A/G cg25457927 chr22:38595422 NA -0.35 -6.82 -0.35 4.36e-11 Cutaneous nevi; LUSC cis rs10191773 0.589 rs72831639 chr2:112949291 A/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.77 7.13 0.36 6.43e-12 Yeast infection; LUSC cis rs16854884 0.770 rs7621093 chr3:143814542 C/G cg06585982 chr3:143692056 C3orf58 0.39 5.9 0.31 8.91e-9 Economic and political preferences (feminism/equality); LUSC cis rs9650315 0.866 rs7838504 chr8:57187301 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs9644630 0.841 rs4292704 chr8:19329303 G/C cg01280390 chr8:19363452 CSGALNACT1 0.36 6.27 0.32 1.11e-9 Oropharynx cancer; LUSC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs12950390 0.853 rs17773010 chr17:45858297 C/T cg03474202 chr17:45855739 NA -0.29 -6.7 -0.34 8.99e-11 IgG glycosylation; LUSC cis rs354225 0.626 rs7591204 chr2:54829458 C/G cg26097391 chr2:54893211 SPTBN1 -0.43 -6.24 -0.32 1.35e-9 Schizophrenia; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg04665974 chr16:30103391 TBX6 0.67 5.94 0.31 7.02e-9 Body mass index; LUSC cis rs7246967 0.611 rs8104052 chr19:22857804 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs7617480 0.648 rs4974088 chr3:48898749 T/C cg21141812 chr3:48556323 PFKFB4 0.33 5.7 0.3 2.64e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7945718 0.934 rs4553350 chr11:12759834 A/G cg25843174 chr11:12811716 TEAD1 -0.32 -7.14 -0.36 5.71e-12 Educational attainment (years of education); LUSC cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.82e-13 Motion sickness; LUSC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.65 10.51 0.5 1.62e-22 Menarche (age at onset); LUSC cis rs9612 0.948 rs12609056 chr19:44258702 G/T cg08581076 chr19:44259116 C19orf61 0.53 6.67 0.34 1.05e-10 Exhaled nitric oxide output; LUSC cis rs4499344 0.556 rs259230 chr19:33133865 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.94 13.79 0.6 1.51e-34 Mean platelet volume; LUSC trans rs11039798 0.764 rs2089208 chr11:48899860 C/T cg03929089 chr4:120376271 NA 0.73 6.8 0.35 4.71e-11 Axial length; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg08859206 chr1:53392774 SCP2 0.56 9.9 0.48 2e-20 Monocyte count; LUSC cis rs7954584 0.505 rs11043278 chr12:122412145 C/T cg21171335 chr12:122356390 WDR66 0.62 9.02 0.44 1.51e-17 Mean corpuscular volume; LUSC cis rs4631830 0.720 rs11599333 chr10:51499655 A/C cg20129853 chr10:51489980 NA 0.36 7.5 0.38 5.8e-13 Prostate-specific antigen levels; LUSC cis rs9398803 0.865 rs1120786 chr6:126808637 T/G cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.88e-9 Male-pattern baldness; LUSC trans rs7618501 0.602 rs9311446 chr3:50092226 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.25 -0.45 2.82e-18 Intelligence (multi-trait analysis); LUSC cis rs9815354 0.597 rs73073281 chr3:42026366 C/T cg03022575 chr3:42003672 ULK4 0.78 7.76 0.39 1.05e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs7246967 0.611 rs73030511 chr19:22826034 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg26395211 chr5:140044315 WDR55 0.46 7.09 0.36 8.28e-12 Depressive symptoms (multi-trait analysis); LUSC trans rs61931739 0.534 rs1826144 chr12:34094272 A/G cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg04414720 chr1:150670196 GOLPH3L -0.49 -7.82 -0.39 7.05e-14 Melanoma; LUSC cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg05347473 chr6:146136440 FBXO30 0.51 8.57 0.42 3.95e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs6499755 0.965 rs9889178 chr16:55353110 G/T cg02859129 chr16:55357253 IRX6 0.35 5.9 0.31 8.94e-9 Hypospadias; LUSC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg19678392 chr7:94953810 PON1 -0.35 -5.68 -0.3 2.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg17264618 chr3:40429014 ENTPD3 0.32 7.04 0.36 1.13e-11 Renal cell carcinoma; LUSC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg11764359 chr7:65958608 NA 0.68 10.85 0.51 1.06e-23 Aortic root size; LUSC trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg15704280 chr7:45808275 SEPT13 0.73 8.21 0.41 4.83e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs9467773 0.620 rs2451737 chr6:26619041 T/C cg09904177 chr6:26538194 HMGN4 0.65 11.67 0.54 1.3e-26 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.534 rs2087128 chr12:34000173 T/C cg13010199 chr12:38710504 ALG10B 0.51 7.65 0.39 2.24e-13 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg00149659 chr3:10157352 C3orf10 0.98 14.09 0.61 1.08e-35 Alzheimer's disease; LUSC cis rs9467773 0.620 rs2451744 chr6:26633463 G/T cg11502198 chr6:26597334 ABT1 0.71 12.06 0.55 4.63e-28 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg14004847 chr7:1930337 MAD1L1 -0.5 -7.33 -0.37 1.74e-12 Bipolar disorder and schizophrenia; LUSC trans rs8073060 0.586 rs2523116 chr17:34025460 T/C cg19694781 chr19:47549865 TMEM160 -1.13 -17.99 -0.7 4.71e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg21733973 chr7:65235735 NA -0.45 -6.46 -0.33 3.73e-10 Calcium levels; LUSC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg07211511 chr3:129823064 LOC729375 -1.24 -20.32 -0.74 2.39e-60 Blood pressure (smoking interaction); LUSC cis rs9457247 0.871 rs1811121 chr6:167403539 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.8 0.63 1.84e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg03806693 chr22:41940476 POLR3H -1.03 -13.99 -0.61 2.43e-35 Crohn's disease;Inflammatory bowel disease; LUSC trans rs7178375 1.000 rs7176351 chr15:31208727 G/A cg04373760 chr16:53404718 NA 0.63 8.53 0.42 5.13e-16 Hypertriglyceridemia; LUSC cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg05347473 chr6:146136440 FBXO30 0.55 9.58 0.46 2.21e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg22903657 chr4:1355424 KIAA1530 -0.4 -6.85 -0.35 3.51e-11 Longevity; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg02951883 chr7:2050386 MAD1L1 -0.4 -6.91 -0.35 2.47e-11 Bipolar disorder and schizophrenia; LUSC cis rs950169 0.800 rs4842847 chr15:84931199 G/A cg17173187 chr15:85201210 NMB 0.36 6.34 0.33 7.63e-10 Schizophrenia; LUSC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg01368799 chr11:117014884 PAFAH1B2 0.51 6.68 0.34 9.92e-11 Blood protein levels; LUSC cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg26384229 chr12:38710491 ALG10B 0.92 15.89 0.66 9.31e-43 Heart rate; LUSC cis rs6546537 1.000 rs4852867 chr2:69831449 G/A cg10773587 chr2:69614142 GFPT1 -0.47 -7.37 -0.37 1.33e-12 Serum thyroid-stimulating hormone levels; LUSC cis rs6977660 0.714 rs6959039 chr7:19818182 T/C cg07541023 chr7:19748670 TWISTNB 0.6 6.51 0.34 2.7e-10 Thyroid stimulating hormone; LUSC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC cis rs4604732 0.588 rs7549955 chr1:247628321 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.78 0.35 5.42e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs11098499 0.554 rs2175381 chr4:120265967 T/C cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.4e-19 Corneal astigmatism; LUSC cis rs9788682 0.747 rs2568490 chr15:78738370 T/C cg24631222 chr15:78858424 CHRNA5 -0.66 -8.64 -0.43 2.3e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs10779751 0.734 rs12569242 chr1:11127511 A/C cg08854313 chr1:11322531 MTOR 0.83 12.26 0.56 8.43e-29 Body mass index; LUSC cis rs16976116 0.901 rs8027256 chr15:55492323 C/A cg11288833 chr15:55489084 RSL24D1 0.5 5.88 0.31 1.02e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs151349 0.743 rs151353 chr20:57604343 A/C cg23907860 chr20:57583709 CTSZ -0.37 -6.04 -0.31 4.02e-9 Platelet distribution width; LUSC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg14552801 chr7:65878734 NA -0.45 -6.51 -0.34 2.84e-10 Aortic root size; LUSC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -8.17 -0.41 6.52e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg19302996 chr17:73780495 UNK -0.5 -7.23 -0.37 3.42e-12 White matter hyperintensity burden; LUSC cis rs722599 0.748 rs17093914 chr14:75363641 A/G cg06637938 chr14:75390232 RPS6KL1 0.42 6.12 0.32 2.64e-9 IgG glycosylation; LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.05 -0.36 1.02e-11 Bipolar disorder; LUSC cis rs1832871 0.643 rs9456282 chr6:158724743 A/G cg07165851 chr6:158734300 TULP4 0.51 7.22 0.37 3.43e-12 Height; LUSC cis rs5758659 0.716 rs86669 chr22:42680800 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.31 -6.46 -0.33 3.77e-10 Cognitive function; LUSC cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg11244672 chr19:19639970 YJEFN3 -0.56 -7.21 -0.37 3.76e-12 Bipolar disorder; LUSC cis rs9467711 0.606 rs68112369 chr6:26365759 T/C cg12826209 chr6:26865740 GUSBL1 0.64 5.71 0.3 2.51e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs78579285 0.544 rs4782321 chr16:88780175 G/A cg01900006 chr16:88814613 FAM38A 0.53 5.74 0.3 2.18e-8 Joint mobility (Beighton score); LUSC cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.54e-19 High light scatter reticulocyte percentage of red cells; LUSC trans rs7127129 0.503 rs7105001 chr11:70051949 T/C cg14529173 chr6:28048874 ZNF165 -0.41 -6.01 -0.31 4.86e-9 Aortic root size; LUSC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg21433313 chr16:3507492 NAT15 0.79 10.04 0.48 6.81e-21 Tuberculosis; LUSC cis rs79149102 0.579 rs3910748 chr15:75318652 A/G cg17294928 chr15:75287854 SCAMP5 -0.71 -6.51 -0.34 2.68e-10 Lung cancer; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg26272237 chr13:111358862 CARS2 -0.41 -6.01 -0.31 4.79e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs8072100 0.967 rs7219303 chr17:45737701 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.94 0.31 7.31e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg02931644 chr1:25747376 RHCE -0.34 -6.3 -0.33 9.4e-10 Erythrocyte sedimentation rate; LUSC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg07636037 chr3:49044803 WDR6 -0.67 -8.82 -0.43 6.53e-17 Menarche (age at onset); LUSC cis rs1570989 0.543 rs6458035 chr6:12015296 A/G cg17804551 chr6:12015979 HIVEP1 0.39 6.9 0.35 2.55e-11 Alcohol and nicotine co-dependence; LUSC cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg14993813 chr1:46806288 NSUN4 -0.5 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs9372498 0.505 rs62422248 chr6:118987610 T/C cg18833306 chr6:118973337 C6orf204 -0.45 -5.76 -0.3 1.93e-8 Diastolic blood pressure; LUSC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg13531842 chr10:38383804 ZNF37A -0.44 -6.85 -0.35 3.62e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7511006 0.893 rs760743 chr22:50647375 C/T cg16473166 chr22:50639996 SELO 0.66 9.25 0.45 2.83e-18 Obesity-related traits; LUSC cis rs72634258 0.891 rs404381 chr1:8080745 C/T cg00042356 chr1:8021962 PARK7 0.65 8.48 0.42 7.38e-16 Inflammatory bowel disease; LUSC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg06618935 chr21:46677482 NA -0.39 -7.86 -0.39 5.51e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4319547 0.656 rs28730465 chr12:122863864 A/C cg05707623 chr12:122985044 ZCCHC8 0.66 8.18 0.41 5.92e-15 Body mass index; LUSC cis rs7786877 0.626 rs11767547 chr7:100221635 C/T cg20848291 chr7:100343083 ZAN -0.57 -6.93 -0.35 2.14e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg13047869 chr3:10149882 C3orf24 0.59 7.75 0.39 1.13e-13 Alzheimer's disease; LUSC trans rs7726558 0.731 rs80248925 chr5:118865325 C/T cg14402224 chr7:50570049 DDC -0.51 -6.52 -0.34 2.6e-10 QT interval (sulfonylurea treatment interaction); LUSC cis rs7432375 0.610 rs28458819 chr3:136522314 A/G cg12473912 chr3:136751656 NA 0.33 5.83 0.3 1.31e-8 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs7904368 0.806 rs7087360 chr10:16872337 C/A cg23933602 chr10:16859644 RSU1 0.53 6.44 0.33 4.16e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs10751667 0.666 rs10902239 chr11:946484 A/G ch.11.42038R chr11:967971 AP2A2 -0.43 -6.48 -0.33 3.28e-10 Alzheimer's disease (late onset); LUSC cis rs7605827 0.930 rs4668445 chr2:15515838 C/T cg19274914 chr2:15703543 NA 0.46 8.8 0.43 7.49e-17 Educational attainment (years of education); LUSC cis rs2762353 0.935 rs1165152 chr6:25818766 A/G cg12310025 chr6:25882481 NA -0.45 -7.82 -0.39 7.19e-14 Blood metabolite levels; LUSC trans rs2832077 0.943 rs11702320 chr21:30195251 A/T cg14791747 chr16:20752902 THUMPD1 0.73 9.55 0.46 2.84e-19 Cognitive test performance; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04350358 chr6:117996341 NUS1 0.44 6.61 0.34 1.52e-10 Triglycerides; LUSC cis rs954108 0.966 rs9508155 chr13:29372016 C/T cg11788234 chr13:29393811 NA 0.39 6.89 0.35 2.74e-11 Obesity-related traits; LUSC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg11752832 chr7:134001865 SLC35B4 0.55 8.61 0.43 2.94e-16 Mean platelet volume; LUSC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.63 0.5 6.32e-23 Schizophrenia; LUSC cis rs6496044 0.568 rs12899946 chr15:86066082 C/T cg13263323 chr15:86062960 AKAP13 -0.38 -6.27 -0.32 1.12e-9 Interstitial lung disease; LUSC cis rs909341 0.678 rs2738778 chr20:62291830 C/T cg16989086 chr20:62203971 PRIC285 0.5 6.58 0.34 1.77e-10 Atopic dermatitis; LUSC cis rs4776059 0.798 rs2414167 chr15:52907428 A/G cg22715398 chr15:52968154 KIAA1370 0.59 7.6 0.38 3.07e-13 Schizophrenia; LUSC cis rs11252926 0.563 rs10904173 chr10:462885 G/A cg03684893 chr10:554711 DIP2C 0.38 6.65 0.34 1.18e-10 Psychosis in Alzheimer's disease; LUSC cis rs5758659 0.652 rs133301 chr22:42390093 C/T cg04733989 chr22:42467013 NAGA 0.39 6.51 0.34 2.77e-10 Cognitive function; LUSC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg22467129 chr15:76604101 ETFA -0.51 -8.22 -0.41 4.49e-15 Blood metabolite levels; LUSC cis rs11098499 0.604 rs2389886 chr4:120570422 C/T cg24375607 chr4:120327624 NA 0.7 10.11 0.48 3.82e-21 Corneal astigmatism; LUSC cis rs12286929 0.609 rs11601751 chr11:115094117 C/T cg04055981 chr11:115044050 NA 0.37 6.65 0.34 1.19e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg16386425 chr10:429943 DIP2C -0.44 -7.06 -0.36 9.96e-12 Psychosis in Alzheimer's disease; LUSC cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg04727924 chr7:799746 HEATR2 -0.54 -6.49 -0.33 3.05e-10 Cerebrospinal P-tau181p levels; LUSC cis rs7131987 0.903 rs11050153 chr12:29405148 T/C cg09582351 chr12:29534625 ERGIC2 -0.3 -6.23 -0.32 1.38e-9 QT interval; LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.0 -0.68 3.84e-47 Gut microbiome composition (summer); LUSC cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg23158103 chr7:148848205 ZNF398 -0.45 -7.06 -0.36 9.42e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6840360 0.554 rs58751443 chr4:152709905 A/G cg22705602 chr4:152727874 NA -0.39 -8.26 -0.41 3.38e-15 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg03676636 chr4:99064102 C4orf37 0.36 7.72 0.39 1.36e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs460214 0.539 rs55819392 chr21:40038207 G/A cg21578987 chr21:40029669 ERG 0.42 6.26 0.32 1.16e-9 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg25282410 chr6:160211355 TCP1;MRPL18 1.07 15.67 0.65 7.17e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg23649088 chr2:200775458 C2orf69 0.5 6.88 0.35 2.97e-11 Schizophrenia; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg04267008 chr7:1944627 MAD1L1 -0.6 -9.27 -0.45 2.32e-18 Bipolar disorder and schizophrenia; LUSC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg27494647 chr7:150038898 RARRES2 0.48 7.34 0.37 1.64e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs12220238 1.000 rs3812638 chr10:75896072 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.91 0.35 2.46e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs8062405 0.755 rs56209193 chr16:28585636 C/T cg16576597 chr16:28551801 NUPR1 0.31 6.31 0.33 8.81e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10752881 1.000 rs10911185 chr1:182971747 G/C ch.1.3577855R chr1:183094577 LAMC1 0.68 10.52 0.5 1.49e-22 Colorectal cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07661818 chr3:190040250 CLDN1 -0.4 -6.6 -0.34 1.61e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00576259 chr1:78225345 USP33 0.47 6.66 0.34 1.11e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg19812747 chr11:111475976 SIK2 0.55 7.77 0.39 1.01e-13 Primary sclerosing cholangitis; LUSC cis rs7833986 0.501 rs2667978 chr8:56897951 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.68 11.17 0.52 8.23e-25 Height; LUSC cis rs72901758 0.768 rs11657271 chr17:76249682 A/T cg25512537 chr17:76250053 NA 0.48 8.62 0.43 2.76e-16 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg03188948 chr7:1209495 NA 0.43 6.35 0.33 6.96e-10 Longevity;Endometriosis; LUSC cis rs1506636 1.000 rs676755 chr7:123439082 A/G cg03229431 chr7:123269106 ASB15 -0.63 -10.24 -0.49 1.43e-21 Plateletcrit;Platelet count; LUSC cis rs3812111 0.510 rs1569825 chr6:116590807 T/G cg18828861 chr6:116576566 TSPYL4 0.38 6.73 0.35 7.41e-11 Age-related macular degeneration; LUSC trans rs9467711 0.606 rs34781270 chr6:26593037 A/G cg06606381 chr12:133084897 FBRSL1 -0.81 -7.09 -0.36 8.24e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg19592336 chr6:28129416 ZNF389 0.47 6.04 0.31 4.21e-9 Depression; LUSC cis rs2073300 0.826 rs6137968 chr20:23449550 G/A cg09953122 chr20:23471693 CST8 -0.68 -6.16 -0.32 2.05e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg15790184 chr11:494944 RNH1 -0.51 -5.81 -0.3 1.45e-8 Body mass index; LUSC cis rs1028488 0.511 rs7738104 chr6:170704196 C/G cg20370364 chr6:170703943 FAM120B -0.51 -7.69 -0.39 1.66e-13 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs6541297 0.938 rs7551742 chr1:230290118 A/G cg20703242 chr1:230279135 GALNT2 0.59 8.84 0.44 5.49e-17 Coronary artery disease; LUSC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.88 0.35 2.89e-11 Menarche (age at onset); LUSC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg21724239 chr8:58056113 NA 0.59 6.75 0.35 6.42e-11 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.72e-10 Bipolar disorder; LUSC cis rs11051970 0.918 rs7309706 chr12:32538208 A/T cg24626660 chr12:32551988 NA 0.38 6.08 0.32 3.36e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12971120 0.891 rs2303463 chr18:72168608 G/A cg25817165 chr18:72167213 CNDP2 -0.75 -9.1 -0.45 8.37e-18 Refractive error; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg11235426 chr6:292522 DUSP22 -0.66 -10.76 -0.51 2.13e-23 Menopause (age at onset); LUSC cis rs5753618 0.583 rs738657 chr22:31841749 T/A cg02404636 chr22:31891804 SFI1 0.38 5.69 0.3 2.77e-8 Colorectal cancer; LUSC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg04414720 chr1:150670196 GOLPH3L -0.48 -7.66 -0.39 2.04e-13 Lymphocyte counts; LUSC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg21724239 chr8:58056113 NA 0.78 8.01 0.4 1.92e-14 Developmental language disorder (linguistic errors); LUSC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg02891314 chr5:179741120 GFPT2 -0.65 -10.62 -0.5 7.07e-23 Height; LUSC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2346177 0.844 rs4953371 chr2:46651143 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.72 -0.39 1.4e-13 HDL cholesterol; LUSC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg20503657 chr10:835505 NA 0.98 13.92 0.61 4.77e-35 Eosinophil percentage of granulocytes; LUSC cis rs8027181 0.797 rs8033580 chr15:72994968 C/A cg25632853 chr15:73088954 NA 0.32 6.62 0.34 1.47e-10 Triglyceride levels; LUSC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg16928487 chr17:17741425 SREBF1 -0.43 -8.43 -0.42 1.03e-15 Total body bone mineral density; LUSC cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg13256891 chr4:100009986 ADH5 0.4 5.87 0.31 1.07e-8 Alcohol dependence; LUSC cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg27129171 chr3:47204927 SETD2 0.55 6.82 0.35 4.28e-11 Birth weight; LUSC cis rs11997175 0.603 rs7001603 chr8:33680978 T/G ch.8.33884649F chr8:33765107 NA 0.48 7.11 0.36 6.95e-12 Body mass index; LUSC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.88e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs936229 0.768 rs12442901 chr15:75083912 A/G cg14664628 chr15:75095509 CSK -1.01 -17.21 -0.69 5.52e-48 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs1728785 1.000 rs4783653 chr16:68562815 C/T cg02972257 chr16:68554789 NA -0.48 -6.19 -0.32 1.76e-9 Ulcerative colitis; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.04e-26 Prudent dietary pattern; LUSC cis rs4332037 0.539 rs11762545 chr7:2060775 C/T cg23422044 chr7:1970798 MAD1L1 -0.57 -6.29 -0.33 1.02e-9 Bipolar disorder; LUSC cis rs7582180 0.613 rs12988464 chr2:100946285 A/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.56 -0.42 4.15e-16 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.45 -0.33 3.88e-10 Lung cancer; LUSC cis rs6665290 0.835 rs7549586 chr1:227214566 A/G cg10327440 chr1:227177885 CDC42BPA -1.21 -36.86 -0.9 9.46e-120 Myeloid white cell count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07344583 chr15:89456631 MFGE8 -0.52 -6.18 -0.32 1.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7523273 0.606 rs2488255 chr1:207941741 C/T cg22525895 chr1:207977042 MIR29B2 0.42 6.77 0.35 5.95e-11 Schizophrenia; LUSC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg19052272 chr2:3704530 ALLC -0.65 -11.19 -0.52 6.48e-25 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2067615 0.524 rs10861645 chr12:107071130 C/T cg15890332 chr12:107067104 RFX4 0.36 6.33 0.33 7.72e-10 Heart rate; LUSC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg17971929 chr21:40555470 PSMG1 0.8 14.01 0.61 2.13e-35 Cognitive function; LUSC cis rs10484885 0.775 rs17584945 chr6:90512776 T/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.06 -0.4 1.4e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7107174 1.000 rs10899475 chr11:78051610 T/C cg02023728 chr11:77925099 USP35 0.43 6.53 0.34 2.41e-10 Testicular germ cell tumor; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg06873352 chr17:61820015 STRADA 0.72 12.97 0.58 1.89e-31 Prudent dietary pattern; LUSC cis rs4727027 0.704 rs2888600 chr7:148908562 C/T cg23583168 chr7:148888333 NA -0.91 -17.2 -0.69 6.17e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs3087591 0.708 rs2525574 chr17:29705947 T/C cg24425628 chr17:29625626 OMG;NF1 0.5 7.42 0.38 9.68e-13 Hip circumference; LUSC cis rs12681287 0.517 rs34367154 chr8:87508749 A/T cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg22963979 chr7:1858916 MAD1L1 -0.56 -8.82 -0.43 6.3e-17 Bipolar disorder and schizophrenia; LUSC trans rs208520 0.560 rs2351880 chr6:66863707 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -16.56 -0.67 2.13e-45 Exhaled nitric oxide output; LUSC cis rs9527 0.615 rs3897401 chr10:104696379 T/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.68 -0.34 1e-10 Arsenic metabolism; LUSC cis rs559928 0.606 rs7941773 chr11:63952759 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 6.99 0.36 1.47e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs1865760 0.566 rs9379825 chr6:26083871 C/A cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs8060686 0.546 rs7188350 chr16:68149316 T/C cg26727032 chr16:67993705 SLC12A4 -0.39 -6.01 -0.31 4.8e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg17385448 chr1:15911702 AGMAT 0.37 6.15 0.32 2.24e-9 Systolic blood pressure; LUSC cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.37 6.81 0.35 4.53e-11 Monocyte percentage of white cells; LUSC cis rs62408225 0.962 rs2325292 chr6:90986749 T/C cg06866423 chr6:90926672 BACH2 0.42 6.03 0.31 4.37e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs9796 0.870 rs7169375 chr15:41311046 A/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -7.02 -0.36 1.24e-11 Menopause (age at onset); LUSC cis rs1385374 0.858 rs11059928 chr12:129296103 A/T cg09035930 chr12:129282057 SLC15A4 -0.64 -6.8 -0.35 4.96e-11 Systemic lupus erythematosus; LUSC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg23262073 chr20:60523788 NA -0.4 -5.71 -0.3 2.5e-8 Body mass index; LUSC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg04850211 chr1:228464232 OBSCN 0.32 5.91 0.31 8.29e-9 Diastolic blood pressure; LUSC cis rs12579753 0.956 rs7959951 chr12:82231132 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.01 -0.31 4.82e-9 Resting heart rate; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18099408 chr3:52552593 STAB1 -0.37 -6.41 -0.33 5.01e-10 Electroencephalogram traits; LUSC cis rs2439831 0.850 rs3742982 chr15:44176681 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.64 0.43 2.3e-16 Lung cancer in ever smokers; LUSC trans rs561341 0.714 rs75861674 chr17:30304317 A/G cg20587970 chr11:113659929 NA -1.12 -15.43 -0.65 6.09e-41 Hip circumference adjusted for BMI; LUSC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg04450456 chr4:17643702 FAM184B 0.35 5.86 0.31 1.14e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3760047 0.668 rs2858922 chr16:207218 G/A cg08400316 chr16:204221 HBZ 0.56 6.75 0.35 6.54e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs9457247 0.602 rs9459854 chr6:167465882 C/T cg25258033 chr6:167368657 RNASET2 0.44 6.61 0.34 1.53e-10 Crohn's disease; LUSC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg11764359 chr7:65958608 NA 0.8 13.45 0.59 3.01e-33 Aortic root size; LUSC cis rs7727544 0.545 rs17674015 chr5:131361778 C/A cg14196790 chr5:131705035 SLC22A5 0.4 6.34 0.33 7.28e-10 Blood metabolite levels; LUSC cis rs7089973 0.604 rs1359079 chr10:116582502 A/G cg25233709 chr10:116636983 FAM160B1 0.38 6.63 0.34 1.38e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs28735056 0.967 rs4799092 chr18:77608203 C/G cg20368463 chr18:77673604 PQLC1 -0.51 -6.63 -0.34 1.37e-10 Schizophrenia; LUSC cis rs9635231 1 rs9635231 chr14:55887703 C/T cg13175173 chr14:55914753 NA -0.28 -5.85 -0.3 1.18e-8 Pediatric bone mineral density (femoral neck); LUSC cis rs1003719 0.715 rs2051398 chr21:38550258 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.65 10.22 0.49 1.58e-21 Eye color traits; LUSC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg08045932 chr20:61659980 NA 0.58 10.21 0.49 1.78e-21 Prostate cancer (SNP x SNP interaction); LUSC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -14.63 -0.62 8.2e-38 Coronary artery disease; LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg02475777 chr4:1388615 CRIPAK 0.44 6.61 0.34 1.56e-10 Obesity-related traits; LUSC cis rs4595586 0.525 rs4511319 chr12:39340457 T/C cg26384229 chr12:38710491 ALG10B 0.5 7.03 0.36 1.15e-11 Morning vs. evening chronotype; LUSC cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.88 0.51 8.19e-24 Bone mineral density; LUSC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg26769984 chr7:1090371 C7orf50 0.47 6.95 0.36 1.9e-11 Bronchopulmonary dysplasia; LUSC cis rs2806561 0.704 rs588387 chr1:23523689 A/G cg19743168 chr1:23544995 NA 0.46 9.11 0.45 8.03e-18 Height; LUSC cis rs7223966 1.000 rs16947005 chr17:61702989 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.5 -7.04 -0.36 1.1e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg04362960 chr10:104952993 NT5C2 0.56 8.07 0.4 1.31e-14 Arsenic metabolism; LUSC cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg15556689 chr8:8085844 FLJ10661 -0.63 -9.74 -0.47 6.6e-20 Mood instability; LUSC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg02187348 chr16:89574699 SPG7 0.49 7.72 0.39 1.37e-13 Multiple myeloma (IgH translocation); LUSC cis rs78456975 1.000 rs11903168 chr2:1560497 C/G cg12573674 chr2:1569213 NA -0.55 -6.03 -0.31 4.38e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs12579753 0.879 rs7958566 chr12:82131478 A/T cg07988820 chr12:82153109 PPFIA2 -0.45 -6.44 -0.33 4.21e-10 Resting heart rate; LUSC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg04398451 chr17:18023971 MYO15A -0.55 -9.23 -0.45 3.16e-18 Total body bone mineral density; LUSC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg02569458 chr12:86230093 RASSF9 -0.59 -10.11 -0.48 3.76e-21 Major depressive disorder; LUSC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11890956 chr21:40555474 PSMG1 1.04 20.98 0.75 6.45e-63 Cognitive function; LUSC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC trans rs4332037 0.624 rs11764124 chr7:1891723 C/G cg10840412 chr1:235813424 GNG4 0.45 6.01 0.31 4.74e-9 Bipolar disorder; LUSC cis rs11190604 1.000 rs2495743 chr10:102329739 G/C cg16342193 chr10:102329863 NA -0.35 -6.14 -0.32 2.39e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg25233709 chr10:116636983 FAM160B1 0.44 7.84 0.39 6.17e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.55 -0.34 2.12e-10 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs425277 1.000 rs809912 chr1:2078385 C/T cg24578937 chr1:2090814 PRKCZ 0.6 13.63 0.6 6e-34 Height; LUSC trans rs4650994 0.544 rs4652301 chr1:178499799 T/C cg05059571 chr16:84539110 KIAA1609 -0.48 -9.16 -0.45 5.48e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs1371867 0.846 rs1788180 chr8:101333368 A/G cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.37e-11 Atrioventricular conduction; LUSC trans rs1908814 0.516 rs4367597 chr8:11793529 C/T cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.77e-9 Neuroticism; LUSC cis rs3760982 1.000 rs10421887 chr19:44294849 C/T cg11993925 chr19:44307056 LYPD5 -0.27 -5.96 -0.31 6.55e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg15884721 chr4:492965 ZNF721;PIGG 0.47 6.16 0.32 2.07e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1561296 0.552 rs2278515 chr2:201282338 C/T cg23649088 chr2:200775458 C2orf69 -0.38 -5.74 -0.3 2.11e-8 Schizophrenia; LUSC trans rs7618501 0.602 rs2301166 chr3:50148305 C/G cg21659725 chr3:3221576 CRBN -0.65 -10.65 -0.5 5.55e-23 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.617 rs3784313 chr15:72187519 G/T cg16672083 chr15:72433130 SENP8 0.47 7.85 0.39 5.71e-14 Red blood cell count; LUSC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg02018176 chr4:1364513 KIAA1530 0.47 7.81 0.39 7.68e-14 Obesity-related traits; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg16405210 chr4:1374714 KIAA1530 -0.56 -9.02 -0.44 1.56e-17 Longevity; LUSC cis rs7582180 0.764 rs13001423 chr2:100925340 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.66 13.9 0.61 5.76e-35 Monocyte percentage of white cells; LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg08470875 chr2:26401718 FAM59B -0.68 -9.27 -0.45 2.44e-18 Gut microbiome composition (summer); LUSC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg11764359 chr7:65958608 NA -0.8 -13.21 -0.59 2.42e-32 Aortic root size; LUSC cis rs17155006 0.664 rs6974722 chr7:107738836 T/C cg05962710 chr7:107745446 LAMB4 -0.36 -6.3 -0.33 9.63e-10 Pneumococcal bacteremia; LUSC cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.94 0.7 7.29e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg18477163 chr1:228402036 OBSCN 0.63 12.24 0.56 1.05e-28 Diastolic blood pressure; LUSC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg23093090 chr10:104574429 C10orf26 -0.39 -7.41 -0.38 1.08e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg21724239 chr8:58056113 NA 0.59 6.73 0.35 7.5e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769707 0.609 rs739247 chr22:49996657 T/C cg20744362 chr22:50050164 C22orf34 0.37 6.78 0.35 5.38e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.59 0.67 1.6e-45 Platelet count; LUSC cis rs12195417 0.563 rs531081 chr6:84216259 G/A cg08257003 chr6:84140564 ME1 -0.28 -6.51 -0.34 2.75e-10 Schizophrenia; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg23131131 chr22:24373011 LOC391322 -0.51 -7.54 -0.38 4.35e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg13047869 chr3:10149882 C3orf24 0.56 7.88 0.4 4.57e-14 Alzheimer's disease; LUSC trans rs6089829 0.962 rs4809462 chr20:61661560 A/G cg17470723 chr8:74884337 TCEB1 0.51 7.87 0.4 4.83e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.79 -0.35 5.03e-11 Alzheimer's disease (late onset); LUSC cis rs9818941 0.826 rs11714264 chr3:157655018 A/G cg08654915 chr3:157813417 NA 0.29 6.56 0.34 2.08e-10 Height; LUSC cis rs2280018 0.963 rs11075255 chr16:15166232 A/G cg27102117 chr16:15229624 NA 0.42 7.24 0.37 3.04e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6933660 0.536 rs3800274 chr6:151759192 T/G cg10883421 chr6:151773342 RMND1;C6orf211 0.52 6.93 0.35 2.18e-11 Menarche (age at onset); LUSC trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs4409675 0.576 rs1474908 chr1:28213213 C/T cg23691781 chr1:28212827 C1orf38 -0.25 -5.73 -0.3 2.2e-8 Corneal astigmatism; LUSC trans rs2797160 1.000 rs1832938 chr6:125988964 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.82 -0.35 4.36e-11 Endometrial cancer; LUSC cis rs1994135 0.715 rs10844625 chr12:33693006 C/T cg06521331 chr12:34319734 NA -0.39 -5.81 -0.3 1.43e-8 Resting heart rate; LUSC cis rs9314323 0.767 rs13271042 chr8:26190212 T/G cg11498726 chr8:26250323 BNIP3L -0.41 -5.84 -0.3 1.24e-8 Red cell distribution width; LUSC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg07424592 chr7:64974309 NA 0.66 5.82 0.3 1.39e-8 Diabetic kidney disease; LUSC trans rs62103177 0.713 rs3744886 chr18:77659561 G/T cg05926928 chr17:57297772 GDPD1 1.56 16.05 0.66 2.18e-43 Opioid sensitivity; LUSC trans rs61931739 0.513 rs1486889 chr12:33901229 A/G cg26384229 chr12:38710491 ALG10B 0.6 9.56 0.46 2.62e-19 Morning vs. evening chronotype; LUSC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs6840360 0.533 rs1397683 chr4:152715916 T/C cg22705602 chr4:152727874 NA 0.38 7.92 0.4 3.61e-14 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.967 rs6142322 chr20:33788538 C/A cg07148914 chr20:33460835 GGT7 -0.43 -6.51 -0.34 2.78e-10 Height; LUSC cis rs7592578 0.771 rs75579212 chr2:191376575 C/T cg10560079 chr2:191398806 TMEM194B -0.76 -9.35 -0.46 1.35e-18 Diastolic blood pressure; LUSC trans rs1864729 1.000 rs2053481 chr8:98278923 C/T cg08679828 chr8:102218111 ZNF706 -0.87 -7.9 -0.4 3.95e-14 Estradiol plasma levels (breast cancer); LUSC cis rs3892630 0.619 rs61062732 chr19:33304717 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.5 -5.65 -0.3 3.48e-8 Red blood cell traits; LUSC cis rs9611565 0.729 rs202654 chr22:41841034 G/A cg03806693 chr22:41940476 POLR3H 0.85 12.41 0.56 2.33e-29 Vitiligo; LUSC cis rs1670533 0.932 rs13140571 chr4:1054358 T/C cg02018176 chr4:1364513 KIAA1530 0.42 5.89 0.31 9.58e-9 Recombination rate (females); LUSC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg09877947 chr5:131593287 PDLIM4 0.4 6.58 0.34 1.81e-10 Lung function (FEV1/FVC); LUSC cis rs12893668 0.645 rs12889403 chr14:104034746 C/T cg08213375 chr14:104286397 PPP1R13B 0.39 6.33 0.33 7.82e-10 Reticulocyte count; LUSC cis rs2762353 0.526 rs6912391 chr6:25710763 C/G cg16482183 chr6:26056742 HIST1H1C -0.41 -5.83 -0.3 1.3e-8 Blood metabolite levels; LUSC trans rs61931739 0.534 rs11052960 chr12:33997754 A/T cg26384229 chr12:38710491 ALG10B 0.74 11.5 0.53 5.04e-26 Morning vs. evening chronotype; LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg12564285 chr5:131593104 PDLIM4 0.47 8.25 0.41 3.83e-15 Acylcarnitine levels; LUSC cis rs7712401 0.601 rs13185741 chr5:122338010 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.22 -0.45 3.4e-18 Mean platelet volume; LUSC trans rs1499614 1.000 rs1882655 chr7:66147057 T/C cg10756647 chr7:56101905 PSPH -0.85 -8.45 -0.42 8.99e-16 Gout; LUSC cis rs11031096 0.754 rs10742242 chr11:4156851 T/C cg18678763 chr11:4115507 RRM1 -0.53 -7.58 -0.38 3.49e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg04450456 chr4:17643702 FAM184B 0.37 6.34 0.33 7.37e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6969780 1.000 rs6948297 chr7:27149404 A/G cg26364809 chr7:27145159 NA -0.62 -6.16 -0.32 2.15e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.67 -0.3 3.11e-8 Life satisfaction; LUSC cis rs4680 0.712 rs740601 chr22:19950763 T/G cg06346307 chr22:19949965 COMT -0.34 -7.03 -0.36 1.18e-11 Blood metabolite levels; LUSC cis rs2932538 0.922 rs17438324 chr1:113100573 C/T cg22162597 chr1:113214053 CAPZA1 0.69 9.93 0.48 1.6e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg07424592 chr7:64974309 NA 0.69 6.18 0.32 1.88e-9 Diabetic kidney disease; LUSC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg19729930 chr2:74357872 NA 0.93 17.38 0.69 1.23e-48 Gestational age at birth (maternal effect); LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg10802521 chr3:52805072 NEK4 -0.55 -8.68 -0.43 1.72e-16 Bipolar disorder; LUSC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.37 -0.33 6.1e-10 Major depressive disorder; LUSC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg20243544 chr17:37824526 PNMT 0.55 8.06 0.4 1.33e-14 Asthma; LUSC cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg01206211 chr2:36825736 FEZ2 -0.47 -9.55 -0.46 2.83e-19 Height; LUSC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg18131467 chr2:239335373 ASB1 0.87 13.84 0.6 9.42e-35 Multiple system atrophy; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.62 0.43 2.69e-16 Prudent dietary pattern; LUSC cis rs12995491 0.902 rs6737641 chr2:88529471 A/T cg18302933 chr2:88491318 NA -0.35 -6.73 -0.35 7.35e-11 Response to metformin (IC50); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02693249 chr1:205600567 ELK4 0.39 5.96 0.31 6.44e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.19 -0.32 1.8e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg11608241 chr8:8085544 FLJ10661 0.39 5.74 0.3 2.14e-8 Mood instability; LUSC cis rs10769945 0.679 rs7102920 chr11:1917872 C/T cg26856596 chr11:1961893 NA 0.31 6.19 0.32 1.74e-9 DNA methylation (variation); LUSC cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg04450456 chr4:17643702 FAM184B 0.4 6.67 0.34 1.09e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23951618 chr1:205782099 SLC41A1 0.44 6.15 0.32 2.26e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 14.84 0.63 1.25e-38 Platelet count; LUSC cis rs7267979 1.000 rs2500418 chr20:25382268 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.41 -0.69 9.13e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7659604 0.540 rs28672860 chr4:122705051 G/A cg06713675 chr4:122721982 EXOSC9 0.39 6.38 0.33 6.06e-10 Type 2 diabetes; LUSC cis rs12638540 0.543 rs12487678 chr3:32603358 A/C cg11605617 chr3:32612461 DYNC1LI1 0.85 7.57 0.38 3.77e-13 Mortality in heart failure; LUSC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg22800045 chr5:56110881 MAP3K1 0.74 9.49 0.46 4.49e-19 Initial pursuit acceleration; LUSC cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg08470875 chr2:26401718 FAM59B -0.7 -9.38 -0.46 1.07e-18 Gut microbiome composition (summer); LUSC cis rs597583 0.715 rs11216436 chr11:117391374 G/A cg27161313 chr11:117392002 DSCAML1 -0.51 -8.43 -0.42 1.02e-15 Putamen volume; LUSC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.88e-8 Tonsillectomy; LUSC cis rs7903847 0.642 rs11817852 chr10:99158426 C/T cg08345082 chr10:99160200 RRP12 -0.35 -6.99 -0.36 1.53e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs7605827 0.893 rs6734024 chr2:15718180 A/G cg19274914 chr2:15703543 NA 0.46 8.77 0.43 9.43e-17 Educational attainment (years of education); LUSC cis rs7917772 0.582 rs12411442 chr10:104349531 A/G cg05855489 chr10:104503620 C10orf26 -0.49 -7.42 -0.38 9.5e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7824557 0.564 rs12550129 chr8:11233917 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.86 -0.4 5.4e-14 Retinal vascular caliber; LUSC cis rs6484504 0.532 rs2774403 chr11:31320530 A/T cg06552810 chr11:31128660 NA 0.4 7.04 0.36 1.08e-11 Red blood cell count; LUSC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.88e-19 Developmental language disorder (linguistic errors); LUSC cis rs7385804 0.633 rs221795 chr7:100283261 C/T cg20848291 chr7:100343083 ZAN 0.4 5.8 0.3 1.51e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs1865760 0.892 rs9379806 chr6:25940958 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 6.56 0.34 2.07e-10 Height; LUSC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg06074448 chr4:187884817 NA -0.41 -6.91 -0.35 2.47e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4588572 0.688 rs2115436 chr5:77692617 A/T cg11547950 chr5:77652471 NA -0.39 -5.94 -0.31 6.99e-9 Triglycerides; LUSC cis rs16910800 0.638 rs12273883 chr11:23164569 C/G cg20040320 chr11:23191996 NA 0.59 7.56 0.38 3.86e-13 Cancer; LUSC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg03146154 chr1:46216737 IPP 0.54 8.25 0.41 3.79e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1008375 1.000 rs1008374 chr4:17683219 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.79 0.35 5.24e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.23e-12 Blood metabolite levels; LUSC cis rs9513627 0.573 rs12431100 chr13:100184918 C/G cg15490075 chr13:100150979 NA -0.6 -6.38 -0.33 5.94e-10 Obesity-related traits; LUSC cis rs12989701 0.825 rs873270 chr2:127859418 T/C cg08168897 chr2:127865431 BIN1 0.68 8.47 0.42 7.99e-16 Alzheimer's disease (late onset); LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg26272228 chr1:95538484 ALG14 0.4 6.08 0.32 3.29e-9 Schizophrenia (age at onset); LUSC trans rs9929218 0.551 rs2296406 chr16:68721340 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.1 27.08 0.83 2.9e-86 Colorectal cancer; LUSC cis rs11098499 0.866 rs7677068 chr4:120291704 C/T cg24375607 chr4:120327624 NA 0.69 10.58 0.5 9.19e-23 Corneal astigmatism; LUSC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg17143192 chr8:8559678 CLDN23 0.63 8.9 0.44 3.56e-17 Obesity-related traits; LUSC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg16928487 chr17:17741425 SREBF1 0.46 8.97 0.44 2.17e-17 Total body bone mineral density; LUSC cis rs2839186 0.786 rs7409792 chr21:47691729 C/A cg05896524 chr21:47604654 C21orf56 0.43 6.5 0.33 2.98e-10 Testicular germ cell tumor; LUSC trans rs1994135 0.617 rs10844644 chr12:33735871 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.32 0.41 2.28e-15 Resting heart rate; LUSC cis rs9527 0.615 rs11191485 chr10:104729816 G/C cg05855489 chr10:104503620 C10orf26 0.53 8.09 0.4 1.1e-14 Arsenic metabolism; LUSC cis rs10751667 1.000 rs10794349 chr11:945678 T/C ch.11.42038R chr11:967971 AP2A2 0.54 8.18 0.41 6.06e-15 Alzheimer's disease (late onset); LUSC cis rs10203711 0.866 rs66849943 chr2:239580956 T/C cg14580085 chr2:239553406 NA 0.41 6.71 0.34 8.12e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs11039798 0.614 rs8188910 chr11:48825740 C/T cg03929089 chr4:120376271 NA 0.72 6.77 0.35 5.71e-11 Axial length; LUSC cis rs6076065 0.723 rs2424534 chr20:23378866 A/G cg11657817 chr20:23433608 CST11 -0.43 -8.02 -0.4 1.81e-14 Facial morphology (factor 15, philtrum width); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19477600 chr11:124632081 ESAM -0.4 -5.96 -0.31 6.48e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1577917 1.000 rs12215037 chr6:86727631 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.08 -0.36 8.81e-12 Response to antipsychotic treatment; LUSC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg13395646 chr4:1353034 KIAA1530 -0.46 -6.99 -0.36 1.51e-11 Obesity-related traits; LUSC cis rs7267979 0.966 rs2261785 chr20:25262403 C/T cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.11e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg26727032 chr16:67993705 SLC12A4 -0.44 -5.94 -0.31 7.16e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11644478 chr21:40555479 PSMG1 0.89 16.15 0.66 8.8e-44 Cognitive function; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg08859206 chr1:53392774 SCP2 0.77 14.82 0.63 1.48e-38 Monocyte count; LUSC cis rs7119 0.651 rs12904533 chr15:77845928 G/A cg27398640 chr15:77910606 LINGO1 -0.33 -6.98 -0.36 1.58e-11 Type 2 diabetes; LUSC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg22532475 chr10:104410764 TRIM8 0.3 5.97 0.31 6.17e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg07636037 chr3:49044803 WDR6 0.67 9.31 0.45 1.82e-18 Menarche (age at onset); LUSC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg09034736 chr1:150693464 HORMAD1 0.45 6.43 0.33 4.36e-10 Melanoma; LUSC cis rs3862435 0.610 rs2601204 chr15:90961518 G/A cg22089800 chr15:90895588 ZNF774 0.58 6.33 0.33 7.74e-10 Response to exercise (triglyceride level interaction); LUSC cis rs9399135 0.935 rs4445070 chr6:135309212 C/T cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.6e-13 Red blood cell count; LUSC cis rs614226 0.938 rs12857 chr12:120933946 T/G cg21053147 chr12:120880522 NA -0.49 -6.03 -0.31 4.43e-9 Type 1 diabetes nephropathy; LUSC cis rs5769765 0.908 rs7410318 chr22:50317049 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.27 -0.49 1.09e-21 Schizophrenia; LUSC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg07716408 chr11:68623521 NA -0.3 -5.67 -0.3 3.18e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2708377 0.929 rs2255418 chr12:11216972 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs8141797 0.901 rs4820581 chr22:24480503 G/A cg00411358 chr22:24577142 SUSD2 0.61 6.32 0.33 8.56e-10 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg17968037 chr7:100024898 ZCWPW1 -0.45 -6.2 -0.32 1.66e-9 Platelet count; LUSC cis rs899997 1.000 rs9888691 chr15:79010046 T/C cg04896959 chr15:78267971 NA 0.51 10.88 0.51 8.18e-24 Coronary artery disease or large artery stroke; LUSC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg02487422 chr3:49467188 NICN1 0.48 7.63 0.39 2.46e-13 Resting heart rate; LUSC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.25 0.56 9.27e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs804280 0.509 rs10109241 chr8:11784985 A/T cg14343924 chr8:8086146 FLJ10661 0.45 6.17 0.32 2e-9 Myopia (pathological); LUSC cis rs6696846 0.765 rs61822567 chr1:205078725 T/C cg00857998 chr1:205179979 DSTYK 0.64 10.09 0.48 4.63e-21 Red blood cell count; LUSC cis rs6733011 0.519 rs6739097 chr2:99458601 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.44 -0.33 4.1e-10 Bipolar disorder; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg02951883 chr7:2050386 MAD1L1 -0.58 -10.62 -0.5 6.88e-23 Bipolar disorder and schizophrenia; LUSC cis rs6500602 0.702 rs4786493 chr16:4500122 C/T cg08645402 chr16:4508243 NA 0.49 8.42 0.42 1.12e-15 Schizophrenia; LUSC cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.25 -0.37 3e-12 Menarche (age at onset); LUSC cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.24e-15 Chronic sinus infection; LUSC trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg03929089 chr4:120376271 NA 0.61 6.6 0.34 1.65e-10 Axial length; LUSC cis rs7818345 0.967 rs4549789 chr8:19284015 C/A cg11303988 chr8:19266685 CSGALNACT1 0.39 7.48 0.38 6.81e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs8078723 1.000 rs4795412 chr17:38150604 C/T cg17467752 chr17:38218738 THRA 0.77 12.39 0.56 2.84e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9303401 0.614 rs62084387 chr17:57148027 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.85 12.32 0.56 5.06e-29 Cognitive test performance; LUSC cis rs7267979 0.932 rs6115215 chr20:25562500 C/T cg03522245 chr20:25566470 NINL 0.36 5.83 0.3 1.29e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg08280861 chr8:58055591 NA 0.54 6.25 0.32 1.26e-9 Developmental language disorder (linguistic errors); LUSC cis rs12594515 1.000 rs8038320 chr15:45990267 G/C cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs9303401 0.659 rs34426768 chr17:56683385 C/T cg25039879 chr17:56429692 SUPT4H1 0.68 9.08 0.45 9.42e-18 Cognitive test performance; LUSC cis rs136211 0.577 rs9607339 chr22:36768932 G/T cg10790723 chr22:36903033 FOXRED2 0.42 6.28 0.32 1.07e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs193541 0.632 rs1460040 chr5:122105232 A/G cg19077854 chr5:122220652 SNX24 0.38 7.9 0.4 4.15e-14 Glucose homeostasis traits; LUSC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg14893161 chr1:205819251 PM20D1 0.43 6.05 0.31 3.86e-9 Parkinson's disease; LUSC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg09165964 chr15:75287851 SCAMP5 -1.01 -15.08 -0.64 1.44e-39 Blood trace element (Zn levels); LUSC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg03452623 chr4:187889614 NA -0.88 -18.58 -0.71 2.09e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs11158026 0.603 rs7151670 chr14:55452759 C/G cg04306507 chr14:55594613 LGALS3 0.4 7.43 0.38 8.92e-13 Parkinson's disease; LUSC cis rs11650494 0.831 rs73324348 chr17:47455752 G/A cg08112188 chr17:47440006 ZNF652 1.24 10.91 0.51 6.64e-24 Prostate cancer; LUSC cis rs11758351 1.000 rs16891397 chr6:26200256 C/T cg01420254 chr6:26195488 NA 0.71 7.46 0.38 7.79e-13 Gout;Renal underexcretion gout; LUSC cis rs17102423 0.559 rs3783720 chr14:65475411 A/G cg11161011 chr14:65562177 MAX -0.72 -9.64 -0.47 1.49e-19 Obesity-related traits; LUSC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg20295408 chr7:1910781 MAD1L1 -0.49 -6.81 -0.35 4.49e-11 Schizophrenia; LUSC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg16405210 chr4:1374714 KIAA1530 -0.66 -10.81 -0.51 1.45e-23 Longevity; LUSC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg03161606 chr19:29218774 NA 0.62 9.08 0.44 9.9e-18 Methadone dose in opioid dependence; LUSC cis rs7953249 0.791 rs1920792 chr12:121404584 T/C cg02403541 chr12:121454288 C12orf43 -0.5 -7.4 -0.38 1.11e-12 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg07701084 chr6:150067640 NUP43 0.56 8.59 0.43 3.4e-16 Lung cancer; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg21280719 chr6:42927975 GNMT -0.32 -7.96 -0.4 2.77e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg15117754 chr3:10150083 C3orf24 0.44 5.75 0.3 1.97e-8 Alzheimer's disease; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg19318889 chr4:1322082 MAEA 0.49 8.44 0.42 9.82e-16 Longevity; LUSC cis rs2836633 0.894 rs55955614 chr21:40037330 T/G cg12884169 chr21:40033163 ERG 0.61 12.33 0.56 4.83e-29 Coronary artery disease; LUSC cis rs7809950 0.862 rs62482502 chr7:106987810 A/C cg23024343 chr7:107201750 COG5 -0.53 -8.36 -0.42 1.69e-15 Coronary artery disease; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg20821713 chr7:1055600 C7orf50 -0.39 -6.14 -0.32 2.29e-9 Longevity;Endometriosis; LUSC cis rs11195062 0.521 rs4918485 chr10:111949323 A/T cg00817464 chr10:111662876 XPNPEP1 0.46 7.17 0.37 4.72e-12 Multiple myeloma; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.44 7.62 0.38 2.59e-13 Electroencephalogram traits; LUSC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg06453172 chr10:134556979 INPP5A -0.46 -5.78 -0.3 1.69e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7223966 1.000 rs2854218 chr17:61942940 A/G cg05941027 chr17:61774174 LIMD2 0.21 5.71 0.3 2.44e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs295140 1.000 rs3769476 chr2:201181428 T/C cg04283868 chr2:201171347 SPATS2L 0.42 6.35 0.33 7.15e-10 QT interval; LUSC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs2979489 0.945 rs11988541 chr8:30334273 G/A cg26383811 chr8:30366931 RBPMS -0.51 -7.93 -0.4 3.24e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg22963979 chr7:1858916 MAD1L1 -0.54 -8.08 -0.4 1.2e-14 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg25767906 chr1:53392781 SCP2 0.51 9.41 0.46 8.33e-19 Monocyte count; LUSC cis rs12701220 0.689 rs6973645 chr7:1112246 C/T cg00990874 chr7:1149470 C7orf50 -0.51 -5.92 -0.31 8.18e-9 Bronchopulmonary dysplasia; LUSC cis rs826838 0.616 rs1601746 chr12:38626195 G/T cg26384229 chr12:38710491 ALG10B -0.59 -8.92 -0.44 3.09e-17 Heart rate; LUSC cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg15557168 chr22:42548783 NA 0.38 6.28 0.32 1.07e-9 Cognitive function; LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg05368731 chr17:41323189 NBR1 -0.93 -15.71 -0.65 5.06e-42 Menopause (age at onset); LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs73200209 0.744 rs17498760 chr12:116636803 C/G cg01776926 chr12:116560359 MED13L -0.5 -6.07 -0.32 3.4e-9 Total body bone mineral density; LUSC cis rs2286503 0.839 rs10276099 chr7:22862950 G/A cg11367502 chr7:22862612 TOMM7 0.46 6.22 0.32 1.51e-9 Fibrinogen; LUSC cis rs955333 0.685 rs17539620 chr6:154896235 G/T cg20019720 chr6:154832845 CNKSR3 0.48 6.23 0.32 1.37e-9 Diabetic kidney disease; LUSC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg17366294 chr4:99064904 C4orf37 0.57 9.94 0.48 1.46e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs62458065 0.850 rs7785659 chr7:32461015 C/T cg00845942 chr12:64062724 DPY19L2 -0.53 -6.25 -0.32 1.28e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.05e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg13206674 chr6:150067644 NUP43 0.62 9.88 0.48 2.38e-20 Lung cancer; LUSC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg20243544 chr17:37824526 PNMT 0.43 6.54 0.34 2.28e-10 Self-reported allergy; LUSC cis rs6840360 0.571 rs2407069 chr4:152533201 G/A cg22705602 chr4:152727874 NA -0.32 -6.59 -0.34 1.73e-10 Intelligence (multi-trait analysis); LUSC cis rs6733011 0.578 rs1581251 chr2:99500867 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.09 -0.32 3.18e-9 Bipolar disorder; LUSC cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg04450456 chr4:17643702 FAM184B 0.36 6.15 0.32 2.2e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9486719 0.948 rs11152952 chr6:96894303 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs137603 0.623 rs137657 chr22:39733242 G/T cg17798944 chr22:39715225 SNORD43;RPL3 -0.5 -7.91 -0.4 3.7e-14 Primary biliary cholangitis; LUSC trans rs7824557 0.564 rs7839307 chr8:11198792 A/G cg06636001 chr8:8085503 FLJ10661 0.52 7.67 0.39 1.86e-13 Retinal vascular caliber; LUSC cis rs17539620 0.507 rs6927301 chr6:154872080 G/T cg20019720 chr6:154832845 CNKSR3 -0.38 -6.41 -0.33 4.86e-10 Lipoprotein (a) levels; LUSC cis rs6940638 0.615 rs9393801 chr6:27242681 A/G cg05738196 chr6:26577821 NA -0.45 -6.37 -0.33 6.2e-10 Intelligence (multi-trait analysis); LUSC cis rs668210 0.793 rs540584 chr11:65765866 C/G cg02202077 chr11:65769826 EIF1AD;BANF1 -0.58 -7.38 -0.37 1.25e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs7824557 0.564 rs7839307 chr8:11198792 A/G cg21775007 chr8:11205619 TDH 0.77 12.32 0.56 5.47e-29 Retinal vascular caliber; LUSC cis rs11098499 0.954 rs13107475 chr4:120393011 A/T cg09307838 chr4:120376055 NA 0.79 11.66 0.54 1.39e-26 Corneal astigmatism; LUSC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs9325144 0.647 rs1875609 chr12:39018259 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.93 -0.48 1.55e-20 Morning vs. evening chronotype; LUSC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.54 -0.38 4.38e-13 Developmental language disorder (linguistic errors); LUSC cis rs12474201 1.000 rs12474201 chr2:46921285 C/T cg06386533 chr2:46925753 SOCS5 0.8 12.83 0.57 6.63e-31 Height; LUSC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg07716408 chr11:68623521 NA -0.31 -5.81 -0.3 1.43e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12681288 0.550 rs6989880 chr8:957209 A/G cg04851639 chr8:1020857 NA -0.35 -6.99 -0.36 1.54e-11 Schizophrenia; LUSC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg06634786 chr22:41940651 POLR3H -0.52 -6.41 -0.33 4.95e-10 Vitiligo; LUSC cis rs9302635 0.513 rs3902135 chr16:72175820 C/T cg01557791 chr16:72042693 DHODH -0.51 -6.69 -0.34 9.7e-11 Blood protein levels; LUSC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg08975724 chr8:8085496 FLJ10661 -0.48 -6.76 -0.35 6.35e-11 Mean corpuscular volume; LUSC cis rs4595586 0.545 rs7958118 chr12:39376685 C/T cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg24531977 chr5:56204891 C5orf35 -0.67 -9.93 -0.48 1.59e-20 Coronary artery disease; LUSC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg15147215 chr3:52552868 STAB1 -0.29 -5.83 -0.3 1.28e-8 Bipolar disorder; LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 14.66 0.63 6.32e-38 Platelet count; LUSC cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg13395646 chr4:1353034 KIAA1530 -0.58 -9.12 -0.45 7.02e-18 Obesity-related traits; LUSC cis rs76878669 0.617 rs10896114 chr11:66143797 A/G cg18002602 chr11:66138449 SLC29A2 -0.37 -5.8 -0.3 1.57e-8 Educational attainment (years of education); LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg20821713 chr7:1055600 C7orf50 -0.39 -6.2 -0.32 1.67e-9 Longevity;Endometriosis; LUSC cis rs7089973 0.668 rs7898347 chr10:116644324 G/A cg23260525 chr10:116636907 FAM160B1 0.4 7.99 0.4 2.26e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs1493916 1.000 rs12457802 chr18:31389865 A/G cg27147174 chr7:100797783 AP1S1 0.64 10.25 0.49 1.32e-21 Life satisfaction; LUSC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg09555818 chr19:45449301 APOC2 0.44 8.18 0.41 5.99e-15 Blood protein levels; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg13395646 chr4:1353034 KIAA1530 -0.63 -10.14 -0.49 2.94e-21 Obesity-related traits; LUSC cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg05855489 chr10:104503620 C10orf26 0.59 9.44 0.46 6.85e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1443512 0.812 rs2044210 chr12:54335533 C/G cg17410650 chr12:54324560 NA -0.58 -10.33 -0.49 6.72e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs250677 0.958 rs10056942 chr5:148416114 C/A cg18129178 chr5:148520854 ABLIM3 -0.65 -10.24 -0.49 1.38e-21 Breast cancer; LUSC trans rs9929218 0.954 rs4420522 chr16:68822971 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.09 -0.52 1.52e-24 Colorectal cancer; LUSC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg22823121 chr1:150693482 HORMAD1 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs7246967 0.541 rs16999009 chr19:22909658 A/G cg23217946 chr19:22817039 ZNF492 -0.43 -5.79 -0.3 1.61e-8 Bronchopulmonary dysplasia; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg20295408 chr7:1910781 MAD1L1 -0.43 -5.95 -0.31 6.83e-9 Bipolar disorder and schizophrenia; LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg07332563 chr6:291687 DUSP22 0.47 7.28 0.37 2.43e-12 Menopause (age at onset); LUSC cis rs738322 0.577 rs4820320 chr22:38572977 G/A cg25457927 chr22:38595422 NA -0.33 -6.28 -0.33 1.04e-9 Cutaneous nevi; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg07167872 chr1:205819463 PM20D1 -0.52 -8.37 -0.42 1.57e-15 Menarche (age at onset); LUSC cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.38 -0.37 1.29e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.43 6.85 0.35 3.61e-11 Alzheimer's disease (late onset); LUSC cis rs9739070 1 rs9739070 chr12:123771032 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -5.72 -0.3 2.4e-8 Allergy; LUSC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.05 0.31 3.81e-9 Schizophrenia; LUSC trans rs7248779 0.512 rs12610522 chr19:2413228 C/T cg25835954 chr13:50160062 RCBTB1 0.53 7.62 0.38 2.62e-13 Cortisol levels (saliva); LUSC cis rs7267979 1.000 rs2424704 chr20:25273929 A/G cg08601574 chr20:25228251 PYGB 0.43 6.6 0.34 1.57e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg25427524 chr10:38739819 LOC399744 -0.63 -11.3 -0.53 2.68e-25 Extrinsic epigenetic age acceleration; LUSC cis rs7267979 0.586 rs6050429 chr20:25183058 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.49 0.56 1.28e-29 Liver enzyme levels (alkaline phosphatase); LUSC trans rs8072100 0.935 rs4793978 chr17:45698175 G/A cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.16e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg16339924 chr4:17578868 LAP3 0.5 7.55 0.38 4.31e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1005277 0.505 rs13503 chr10:38239843 C/A cg17830980 chr10:43048298 ZNF37B 0.46 7.12 0.36 6.73e-12 Extrinsic epigenetic age acceleration; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg08088566 chr11:430123 ANO9 0.67 7.4 0.38 1.08e-12 Body mass index; LUSC trans rs6598955 0.671 rs12145403 chr1:26597189 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.45 -0.42 9.12e-16 Obesity-related traits; LUSC cis rs8036030 0.691 rs11852760 chr15:74718699 A/G cg10253484 chr15:75165896 SCAMP2 -0.41 -5.94 -0.31 7e-9 Airflow obstruction; LUSC cis rs240764 0.658 rs12212435 chr6:101196080 T/C cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC cis rs2050392 0.965 rs2265368 chr10:30690289 G/C cg18806716 chr10:30721971 MAP3K8 -0.43 -6.99 -0.36 1.52e-11 Inflammatory bowel disease; LUSC trans rs11098499 0.754 rs7672778 chr4:120248585 A/G cg25214090 chr10:38739885 LOC399744 0.43 6.59 0.34 1.72e-10 Corneal astigmatism; LUSC cis rs4268898 0.931 rs7603997 chr2:24524958 C/T cg06627628 chr2:24431161 ITSN2 -0.63 -9.37 -0.46 1.16e-18 Asthma; LUSC cis rs6840360 0.582 rs6535796 chr4:152304728 G/A cg20465933 chr4:152376761 FAM160A1 0.32 5.68 0.3 2.92e-8 Intelligence (multi-trait analysis); LUSC cis rs722599 0.683 rs11848876 chr14:75224626 C/G cg06637938 chr14:75390232 RPS6KL1 0.41 5.96 0.31 6.34e-9 IgG glycosylation; LUSC cis rs738321 0.725 rs4821747 chr22:38538856 T/C cg25457927 chr22:38595422 NA -0.34 -6.37 -0.33 6.24e-10 Breast cancer; LUSC cis rs4363385 0.647 rs4845513 chr1:152998066 T/C cg25856811 chr1:152973957 SPRR3 -0.41 -6.63 -0.34 1.34e-10 Inflammatory skin disease; LUSC cis rs9359856 0.564 rs7682 chr6:90352862 G/A cg13799429 chr6:90582589 CASP8AP2 -0.86 -8.64 -0.43 2.39e-16 Bipolar disorder; LUSC cis rs734999 0.588 rs11585048 chr1:2534087 C/T cg18854424 chr1:2615690 NA 0.5 10.1 0.48 4.29e-21 Ulcerative colitis; LUSC trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg03929089 chr4:120376271 NA -0.6 -7.24 -0.37 3.14e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC trans rs9388451 0.874 rs7739566 chr6:126094757 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.34 -0.46 1.42e-18 Brugada syndrome; LUSC cis rs9815354 0.680 rs57945879 chr3:42038842 C/G cg03022575 chr3:42003672 ULK4 0.78 7.87 0.4 5.1e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.74 -12.73 -0.57 1.56e-30 Total body bone mineral density; LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18404041 chr3:52824283 ITIH1 -0.58 -11.05 -0.52 2.07e-24 Bipolar disorder; LUSC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.49 0.33 3.16e-10 Melanoma; LUSC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.75 0.3 2e-8 Tonsillectomy; LUSC cis rs8078723 0.714 rs8070444 chr17:38151960 A/G cg17467752 chr17:38218738 THRA -0.71 -11.37 -0.53 1.49e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18078305 chr2:65215753 SLC1A4 0.4 6.53 0.34 2.44e-10 Triglycerides; LUSC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg22029157 chr1:209979665 IRF6 0.47 7.24 0.37 3.02e-12 Monobrow; LUSC cis rs2760061 0.784 rs1745414 chr1:228212159 T/A cg04850211 chr1:228464232 OBSCN -0.32 -5.82 -0.3 1.42e-8 Diastolic blood pressure; LUSC trans rs8072100 0.967 rs4338849 chr17:45512483 A/G cg03886242 chr7:26192032 NFE2L3 -0.37 -6.06 -0.31 3.65e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg11102782 chr19:18549136 ISYNA1 -0.33 -6.41 -0.33 4.86e-10 Breast cancer; LUSC cis rs9399135 0.967 rs952674 chr6:135349157 A/G cg22676075 chr6:135203613 NA 0.47 7.37 0.37 1.32e-12 Red blood cell count; LUSC cis rs35306767 0.714 rs12767171 chr10:1084491 A/G cg26597838 chr10:835615 NA 0.53 7.13 0.36 6.44e-12 Eosinophil percentage of granulocytes; LUSC cis rs908922 0.676 rs12129646 chr1:152518816 C/T cg20991723 chr1:152506922 NA 0.5 9.44 0.46 6.51e-19 Hair morphology; LUSC cis rs12310956 0.532 rs7979535 chr12:33947450 A/C cg06521331 chr12:34319734 NA 0.44 7.11 0.36 6.9e-12 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25228510 chr10:62538235 CDK1;CDC2 -0.58 -6.82 -0.35 4.39e-11 Bipolar disorder and schizophrenia; LUSC cis rs9653442 0.835 rs7565967 chr2:100744683 G/T cg07810366 chr2:100720526 AFF3 -0.53 -9.25 -0.45 2.81e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.62e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg16339924 chr4:17578868 LAP3 0.58 9.09 0.45 9.01e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs910316 0.726 rs12882664 chr14:75446778 C/T cg11812906 chr14:75593930 NEK9 0.65 10.6 0.5 8.14e-23 Height; LUSC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg07507251 chr3:52567010 NT5DC2 -0.36 -7.03 -0.36 1.15e-11 Bipolar disorder; LUSC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.59 0.38 3.31e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg08999081 chr20:33150536 PIGU -0.41 -7.56 -0.38 3.88e-13 Glomerular filtration rate (creatinine); LUSC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg24209194 chr3:40518798 ZNF619 0.49 6.5 0.34 2.87e-10 Renal cell carcinoma; LUSC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg02788857 chr8:22132959 PIWIL2 0.39 7.5 0.38 6.01e-13 Hypertriglyceridemia; LUSC cis rs12421382 0.659 rs1371331 chr11:109382578 G/A cg16359550 chr11:109292809 C11orf87 0.37 6.37 0.33 6.29e-10 Schizophrenia; LUSC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06634786 chr22:41940651 POLR3H -0.54 -6.32 -0.33 8.48e-10 Vitiligo; LUSC cis rs9527 0.590 rs763914 chr10:104841587 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -6.89 -0.35 2.73e-11 Arsenic metabolism; LUSC trans rs656319 0.580 rs17690549 chr8:9998538 C/G cg15556689 chr8:8085844 FLJ10661 -0.52 -7.51 -0.38 5.53e-13 Myopia (pathological); LUSC cis rs6987853 0.933 rs6474401 chr8:42367068 T/C cg09913449 chr8:42400586 C8orf40 -0.48 -7.95 -0.4 2.82e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg01256987 chr12:42539512 GXYLT1 -0.46 -8.61 -0.43 2.88e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs656319 0.605 rs17747335 chr8:10003186 A/T cg27411982 chr8:10470053 RP1L1 -0.39 -5.93 -0.31 7.4e-9 Myopia (pathological); LUSC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg26597838 chr10:835615 NA 0.76 9.03 0.44 1.37e-17 Eosinophil percentage of granulocytes; LUSC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.45 -6.33 -0.33 8.1e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs11039798 0.858 rs7121333 chr11:48332138 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.34 9.17e-11 Axial length; LUSC cis rs34891900 0.507 rs12167771 chr22:18124332 G/A cg08824373 chr22:18117835 NA -0.44 -6.74 -0.35 7.05e-11 Sum neutrophil eosinophil counts; LUSC cis rs10193935 0.901 rs7570083 chr2:42517859 G/A cg27598129 chr2:42591480 NA -0.58 -8.08 -0.4 1.19e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg11494091 chr17:61959527 GH2 0.63 13.84 0.6 9.97e-35 Prudent dietary pattern; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 13.0 0.58 1.5e-31 Alzheimer's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11948688 chr8:1712330 CLN8 -0.42 -6.57 -0.34 1.91e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs17607347 0.542 rs7199954 chr16:72489414 C/T cg24341770 chr6:105148882 NA 0.48 5.95 0.31 6.63e-9 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.99 0.4 2.24e-14 Prudent dietary pattern; LUSC cis rs8078723 0.714 rs3859187 chr17:38150613 C/A cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.37 0.37 1.39e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs3815700 1.000 rs10406750 chr19:33097144 C/T cg02997394 chr19:33096574 ANKRD27 0.83 9.48 0.46 4.95e-19 Eosinophilic esophagitis; LUSC trans rs5756813 0.688 rs2413483 chr22:38127950 C/T cg19894588 chr14:64061835 NA -0.51 -6.67 -0.34 1.07e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg06873352 chr17:61820015 STRADA 0.73 13.09 0.58 7.01e-32 Prudent dietary pattern; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27561072 chr1:19812431 CAPZB -0.41 -6.07 -0.32 3.41e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg06212747 chr3:49208901 KLHDC8B 0.59 8.24 0.41 3.86e-15 Menarche (age at onset); LUSC cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.04 0.4 1.54e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg00944433 chr1:107599041 PRMT6 0.38 6.96 0.36 1.83e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs10028773 0.515 rs9994488 chr4:120587781 C/T cg09307838 chr4:120376055 NA 0.61 8.84 0.44 5.79e-17 Educational attainment; LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.48 0.75 5.81e-61 Prudent dietary pattern; LUSC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg01368799 chr11:117014884 PAFAH1B2 0.62 9.9 0.48 1.91e-20 Blood protein levels; LUSC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -9.02 -0.44 1.56e-17 Personality dimensions; LUSC cis rs9287719 0.967 rs11687023 chr2:10741412 G/A cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11890956 chr21:40555474 PSMG1 1.02 20.48 0.75 5.84e-61 Cognitive function; LUSC cis rs308403 0.509 rs1849430 chr4:123674701 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.96 16.63 0.67 1.1e-45 Blood protein levels; LUSC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.81 -0.35 4.64e-11 Alzheimer's disease (late onset); LUSC cis rs897080 0.552 rs1085443 chr2:44635015 A/G cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg12963246 chr6:28129442 ZNF389 0.48 6.73 0.35 7.46e-11 Depression; LUSC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg20891283 chr12:69753455 YEATS4 0.64 9.95 0.48 1.3e-20 Blood protein levels; LUSC cis rs6882046 0.513 rs625970 chr5:88042296 A/G cg22951263 chr5:87985283 NA -0.47 -7.91 -0.4 3.8e-14 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg13628971 chr7:2884303 GNA12 0.46 6.58 0.34 1.84e-10 Height; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.08e-17 Prudent dietary pattern; LUSC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg13390004 chr1:15929781 NA 0.43 7.12 0.36 6.55e-12 Systolic blood pressure; LUSC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg09877947 chr5:131593287 PDLIM4 -0.38 -6.19 -0.32 1.72e-9 Breast cancer;Mosquito bite size; LUSC cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg03605463 chr16:89740564 NA 0.48 7.11 0.36 7.25e-12 Vitiligo; LUSC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg20790798 chr5:1857306 NA -0.5 -8.42 -0.42 1.09e-15 Cardiovascular disease risk factors; LUSC cis rs365132 0.875 rs4490607 chr5:176349386 T/C cg25401027 chr5:176370377 UIMC1 0.35 5.74 0.3 2.11e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg04362960 chr10:104952993 NT5C2 -0.48 -6.02 -0.31 4.52e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9648716 0.515 rs58901822 chr7:140683175 G/A cg23214464 chr7:140373596 ADCK2 0.7 5.92 0.31 7.78e-9 Type 2 diabetes; LUSC cis rs59104589 0.583 rs28386824 chr2:242349893 A/G cg14842376 chr2:242211374 HDLBP 0.53 6.22 0.32 1.53e-9 Fibrinogen levels; LUSC cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg12011299 chr4:100065546 ADH4 0.71 10.76 0.51 2.23e-23 Smoking initiation; LUSC cis rs3771570 0.901 rs55811034 chr2:242406245 C/T cg21155796 chr2:242212141 HDLBP 0.61 6.93 0.35 2.13e-11 Prostate cancer; LUSC cis rs11997175 0.653 rs4268089 chr8:33626532 G/A ch.8.33884649F chr8:33765107 NA 0.44 7.13 0.36 6.37e-12 Body mass index; LUSC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg06212747 chr3:49208901 KLHDC8B 0.43 5.86 0.31 1.1e-8 Parkinson's disease; LUSC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg17911788 chr17:44343683 NA -0.31 -5.88 -0.31 1.02e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg21724239 chr8:58056113 NA 0.59 6.76 0.35 6.3e-11 Developmental language disorder (linguistic errors); LUSC trans rs11992162 0.597 rs6996342 chr8:11784541 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.47 -0.33 3.58e-10 Monocyte count; LUSC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg04155289 chr7:94953770 PON1 -0.34 -5.83 -0.3 1.33e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs3774830 0.714 rs17464616 chr4:5465004 G/A cg26943120 chr4:5472116 STK32B 0.29 5.77 0.3 1.84e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg16520312 chr17:43971471 MAPT;LOC100128977 -0.37 -6.4 -0.33 5.39e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs34779708 0.931 rs4934704 chr10:35332164 C/T cg04310649 chr10:35416472 CREM -0.4 -6.14 -0.32 2.32e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11122272 0.766 rs1435166 chr1:231502310 T/C cg06096015 chr1:231504339 EGLN1 0.55 9.58 0.46 2.23e-19 Hemoglobin concentration; LUSC cis rs4077515 0.577 rs3812584 chr9:139312719 C/T cg14169450 chr9:139327907 INPP5E -0.41 -7.25 -0.37 2.86e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22713941 chr2:105953959 C2orf49 -0.45 -6.63 -0.34 1.36e-10 Electrocardiographic conduction measures; LUSC trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg03929089 chr4:120376271 NA -0.55 -6.74 -0.35 6.84e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.16 -0.49 2.58e-21 Developmental language disorder (linguistic errors); LUSC cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg11102782 chr19:18549136 ISYNA1 -0.35 -6.4 -0.33 5.2400000000000005e-10 Breast cancer; LUSC cis rs10769945 0.679 rs7102920 chr11:1917872 C/T cg06197492 chr11:2016605 H19 0.42 7.36 0.37 1.4e-12 DNA methylation (variation); LUSC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg15352829 chr14:105391018 PLD4 -0.41 -8.48 -0.42 7.48e-16 Rheumatoid arthritis; LUSC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg13798780 chr7:105162888 PUS7 0.6 6.46 0.33 3.61e-10 Bipolar disorder (body mass index interaction); LUSC cis rs6681460 0.898 rs1032635 chr1:67195184 C/G cg02459107 chr1:67143332 SGIP1 -0.47 -8.74 -0.43 1.14e-16 Presence of antiphospholipid antibodies; LUSC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg21724239 chr8:58056113 NA 0.54 6.14 0.32 2.28e-9 Developmental language disorder (linguistic errors); LUSC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg12310025 chr6:25882481 NA 0.6 9.88 0.48 2.28e-20 Blood metabolite levels; LUSC cis rs73129298 0.551 rs6091078 chr20:48603066 G/A cg25655593 chr20:48599521 SNAI1 0.58 6.18 0.32 1.88e-9 Inflammatory skin disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10480950 chr6:5067127 NA 0.4 6.15 0.32 2.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2446066 0.872 rs2002555 chr12:53817237 A/G cg20730629 chr12:53886622 MAP3K12 -0.42 -5.69 -0.3 2.71e-8 Red blood cell count; LUSC cis rs8027181 0.839 rs62017600 chr15:73072236 T/A cg25632853 chr15:73088954 NA 0.33 6.68 0.34 9.78e-11 Triglyceride levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15672331 chr15:85923765 AKAP13 0.47 7.61 0.38 2.81e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg09904177 chr6:26538194 HMGN4 -0.68 -12.02 -0.55 6.8e-28 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg20203395 chr5:56204925 C5orf35 -0.78 -10.48 -0.5 2.01e-22 Initial pursuit acceleration; LUSC cis rs11971779 0.648 rs6974099 chr7:139098566 A/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg05872129 chr22:39784769 NA -0.62 -11.7 -0.54 9.59e-27 Intelligence (multi-trait analysis); LUSC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs34638657 0.536 rs2967327 chr16:82188657 C/T cg09439754 chr16:82129088 HSD17B2 -0.33 -5.99 -0.31 5.54e-9 Lung adenocarcinoma; LUSC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg20821713 chr7:1055600 C7orf50 -0.54 -7.15 -0.36 5.67e-12 Bronchopulmonary dysplasia; LUSC cis rs34779708 0.966 rs2126984 chr10:35410291 A/G cg04310649 chr10:35416472 CREM -0.38 -6.14 -0.32 2.28e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg24642439 chr20:33292090 TP53INP2 0.73 11.94 0.55 1.37e-27 Coronary artery disease; LUSC cis rs73198271 0.562 rs17631022 chr8:8662197 G/A cg01851573 chr8:8652454 MFHAS1 0.62 7.89 0.4 4.28e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg01475377 chr6:109611718 NA -0.41 -7.36 -0.37 1.47e-12 Reticulocyte fraction of red cells; LUSC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC trans rs8072100 0.967 rs7219303 chr17:45737701 A/G cg04995722 chr7:26192034 NFE2L3 0.37 6.13 0.32 2.51e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1395 0.922 rs11693052 chr2:27484620 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.39 6.3 0.33 9.31e-10 Blood metabolite levels; LUSC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg19774624 chr17:42201019 HDAC5 -0.8 -13.41 -0.59 4.28e-33 Total body bone mineral density; LUSC trans rs1997103 1.000 rs6593237 chr7:55411015 T/C cg20935933 chr6:143382018 AIG1 0.5 7.42 0.38 9.57e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs611744 0.560 rs58605513 chr8:109279122 A/C cg21045802 chr8:109455806 TTC35 0.42 6.58 0.34 1.79e-10 Dupuytren's disease; LUSC cis rs5758659 0.569 rs133293 chr22:42382797 G/A cg04733989 chr22:42467013 NAGA 0.37 6.13 0.32 2.41e-9 Cognitive function; LUSC trans rs8073060 0.544 rs225252 chr17:33952401 G/A cg19694781 chr19:47549865 TMEM160 -1.13 -18.17 -0.71 8.74e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs11190604 1.000 rs28522614 chr10:102323141 T/A cg07080220 chr10:102295463 HIF1AN 0.65 7.96 0.4 2.68e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11690935 0.959 rs3770452 chr2:172668682 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.43 -0.62 4.96e-37 Schizophrenia; LUSC cis rs11190604 1.000 rs17113137 chr10:102241998 G/C cg16342193 chr10:102329863 NA -0.34 -6.15 -0.32 2.22e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4478037 1.000 rs57477065 chr3:33162532 A/C cg19404215 chr3:33155277 CRTAP 0.95 9.99 0.48 9.87e-21 Major depressive disorder; LUSC cis rs8133932 0.701 rs2839054 chr21:47328449 A/G cg14185626 chr21:47401492 COL6A1 0.44 5.68 0.3 2.98e-8 Schizophrenia; LUSC cis rs8062405 0.688 rs3924376 chr16:28925978 T/C cg05966235 chr16:28915196 ATP2A1 -0.34 -5.74 -0.3 2.16e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg22166914 chr1:53195759 ZYG11B 0.68 11.33 0.53 2.09e-25 Monocyte count; LUSC trans rs1459104 0.714 rs1851614 chr11:54836269 C/T cg03929089 chr4:120376271 NA 0.75 6.45 0.33 3.92e-10 Body mass index; LUSC cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg21926612 chr6:163149169 PACRG;PARK2 1.18 15.2 0.64 5.15e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs983392 0.667 rs631853 chr11:59944898 T/G cg20284999 chr11:59952153 MS4A6A 0.36 6.36 0.33 6.5e-10 Alzheimer's disease (late onset); LUSC trans rs11098499 0.789 rs10212719 chr4:120254437 T/C cg25214090 chr10:38739885 LOC399744 0.42 6.45 0.33 4.03e-10 Corneal astigmatism; LUSC cis rs10740039 0.846 rs10761529 chr10:62386810 C/G cg18175470 chr10:62150864 ANK3 -0.45 -6.89 -0.35 2.8e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs1997103 1.000 rs2331065 chr7:55408392 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg22467129 chr15:76604101 ETFA -0.53 -8.87 -0.44 4.4e-17 Blood metabolite levels; LUSC cis rs1577917 0.958 rs884842 chr6:86680397 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.79e-10 Response to antipsychotic treatment; LUSC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg00409905 chr10:38381863 ZNF37A -0.4 -6.79 -0.35 5e-11 Extrinsic epigenetic age acceleration; LUSC cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg24675056 chr1:15929824 NA 0.47 8.07 0.4 1.32e-14 Systolic blood pressure; LUSC cis rs7772486 0.743 rs111332144 chr6:146056681 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.36 -0.56 3.88e-29 Lobe attachment (rater-scored or self-reported); LUSC trans rs60843830 0.661 rs7561648 chr2:105171 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.51 8.02 0.4 1.79e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs10186029 0.676 rs4673720 chr2:213941581 G/A cg08319019 chr2:214017104 IKZF2 0.61 8.95 0.44 2.55e-17 Systemic sclerosis; LUSC cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.04 -0.36 1.13e-11 Menopause (age at onset); LUSC cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg24642439 chr20:33292090 TP53INP2 0.47 7.02 0.36 1.23e-11 Glomerular filtration rate (creatinine); LUSC cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg05585544 chr11:47624801 NA -0.44 -7.65 -0.39 2.15e-13 Subjective well-being; LUSC cis rs9393777 0.557 rs6933999 chr6:27074929 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.45 -8.07 -0.4 1.29e-14 Intelligence (multi-trait analysis); LUSC cis rs55675132 0.833 rs7543383 chr1:115647658 T/A cg01522456 chr1:115632236 TSPAN2 -0.46 -5.82 -0.3 1.39e-8 Schizophrenia; LUSC cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg05535760 chr7:792225 HEATR2 0.77 9.06 0.44 1.13e-17 Cerebrospinal P-tau181p levels; LUSC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg03929089 chr4:120376271 NA -0.76 -12.12 -0.55 2.8e-28 Height; LUSC cis rs4664308 1.000 rs56297666 chr2:160902023 G/C cg03641300 chr2:160917029 PLA2R1 -0.65 -10.91 -0.51 6.44e-24 Idiopathic membranous nephropathy; LUSC cis rs11098499 0.909 rs9759478 chr4:120367998 G/A cg24375607 chr4:120327624 NA 0.79 11.7 0.54 1.01e-26 Corneal astigmatism; LUSC cis rs7107174 1.000 rs2512550 chr11:77943848 C/T cg02023728 chr11:77925099 USP35 0.43 6.28 0.33 1.04e-9 Testicular germ cell tumor; LUSC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.44 5.78 0.3 1.7e-8 Renal function-related traits (BUN); LUSC cis rs7507204 0.530 rs4807470 chr19:3443470 A/T cg08380311 chr19:3435252 NFIC 0.85 15.96 0.66 5.12e-43 Height; LUSC cis rs11039100 0.834 rs11039053 chr11:5812827 T/C cg05234568 chr11:5960015 NA -0.51 -5.78 -0.3 1.71e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg13206674 chr6:150067644 NUP43 0.58 9.08 0.45 9.37e-18 Lung cancer; LUSC cis rs6987853 0.966 rs1901282 chr8:42392942 C/G cg09913449 chr8:42400586 C8orf40 0.49 8.3 0.41 2.56e-15 Mean corpuscular hemoglobin concentration; LUSC trans rs870142 0.922 rs10012393 chr4:4637186 G/A cg04017672 chr1:182359056 GLUL 0.41 6.12 0.32 2.59e-9 Congenital heart disease; LUSC cis rs4561483 0.799 rs33635 chr16:11991944 C/T cg08843971 chr16:11963173 GSPT1 -0.44 -6.3 -0.33 9.13e-10 Testicular germ cell tumor; LUSC cis rs6554196 0.508 rs7695300 chr4:55512066 T/C cg18836493 chr4:55524333 KIT -0.45 -7.92 -0.4 3.67e-14 Monocyte count; LUSC cis rs477692 0.870 rs475250 chr10:131412558 C/G cg26102564 chr10:131424627 MGMT 0.38 5.93 0.31 7.52e-9 Response to temozolomide; LUSC cis rs6546537 0.911 rs4852898 chr2:69872797 C/T cg10773587 chr2:69614142 GFPT1 -0.53 -7.92 -0.4 3.65e-14 Serum thyroid-stimulating hormone levels; LUSC cis rs1215050 0.740 rs783929 chr4:98972495 T/A cg05340658 chr4:99064831 C4orf37 -0.47 -7.43 -0.38 8.98e-13 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1372520 0.873 rs2737026 chr4:90779823 A/G cg01966878 chr4:90757139 SNCA -0.42 -5.92 -0.31 7.9e-9 Neuroticism; LUSC cis rs1348850 0.567 rs880899 chr2:178532416 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.91 0.31 8.37e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg04450456 chr4:17643702 FAM184B 0.37 6.33 0.33 7.86e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3008870 1.000 rs2985811 chr1:67377722 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.26 0.64 2.81e-40 Lymphocyte percentage of white cells; LUSC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg15921436 chr17:44337874 NA -0.7 -10.71 -0.51 3.28e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg19468946 chr17:37922297 IKZF3 -0.39 -6.22 -0.32 1.51e-9 Asthma; LUSC cis rs7829975 0.846 rs6601724 chr8:8544872 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -7.09 -0.36 8.2e-12 Mood instability; LUSC cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg23711669 chr6:146136114 FBXO30 -0.89 -16.73 -0.68 4.43e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13980079 chr4:1980637 WHSC1 0.39 5.99 0.31 5.35e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12579753 1.000 rs17748942 chr12:82170478 G/A cg21231944 chr12:82153410 PPFIA2 -0.39 -5.97 -0.31 6.07e-9 Resting heart rate; LUSC cis rs2742417 1.000 rs2673034 chr3:45755138 A/G cg09608765 chr3:45636137 LIMD1 -0.39 -7.81 -0.39 7.4e-14 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11122272 0.766 rs2790872 chr1:231540543 A/T cg06096015 chr1:231504339 EGLN1 0.55 9.59 0.46 2.18e-19 Hemoglobin concentration; LUSC cis rs6445967 0.530 rs12634132 chr3:58409082 A/G cg13705284 chr3:58523313 ACOX2 -0.27 -5.71 -0.3 2.46e-8 Platelet count; LUSC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg06636001 chr8:8085503 FLJ10661 -0.85 -14.94 -0.63 5.1e-39 Neuroticism; LUSC cis rs2871473 1.000 rs2871473 chr2:103107280 A/C cg09003973 chr2:102972529 NA 0.64 7.28 0.37 2.36e-12 Blood protein levels; LUSC cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.44e-8 Intelligence (multi-trait analysis); LUSC cis rs908922 0.584 rs10888500 chr1:152532749 G/A cg20991723 chr1:152506922 NA 0.48 8.82 0.43 6.41e-17 Hair morphology; LUSC cis rs1577917 1.000 rs12201880 chr6:86627007 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC cis rs7903847 0.642 rs11817852 chr10:99158426 C/T cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.59e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs4654899 0.965 rs61779124 chr1:21513306 C/T cg01072550 chr1:21505969 NA -0.55 -8.54 -0.42 4.89e-16 Superior frontal gyrus grey matter volume; LUSC cis rs7904368 0.806 rs6602161 chr10:16862280 A/G cg14835575 chr10:16859367 RSU1 0.79 10.76 0.51 2.27e-23 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg15383120 chr6:291909 DUSP22 -0.44 -6.47 -0.33 3.59e-10 Menopause (age at onset); LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg20821713 chr7:1055600 C7orf50 -0.46 -7.42 -0.38 9.63e-13 Longevity;Endometriosis; LUSC cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.18 0.41 6.07e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4478858 0.746 rs12136121 chr1:31689743 G/C cg00250761 chr1:31883323 NA 0.37 9.4 0.46 8.95e-19 Alcohol dependence; LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg09877947 chr5:131593287 PDLIM4 0.59 10.02 0.48 7.64e-21 Acylcarnitine levels; LUSC cis rs1559088 0.947 rs12461219 chr19:33550633 C/G cg03563238 chr19:33554763 RHPN2 -0.41 -6.47 -0.33 3.59e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17401966 0.558 rs6541090 chr1:10402842 A/G cg17425144 chr1:10567563 PEX14 -0.34 -6.16 -0.32 2.1e-9 Hepatocellular carcinoma; LUSC trans rs8030485 0.571 rs939654 chr15:79415218 G/A cg16586880 chr8:140854244 TRAPPC9 -0.37 -5.98 -0.31 5.84e-9 Left ventricle wall thickness; LUSC cis rs3808502 0.527 rs2736389 chr8:11161310 C/A cg27411982 chr8:10470053 RP1L1 0.38 5.73 0.3 2.21e-8 Neuroticism; LUSC cis rs12908161 1.000 rs11638290 chr15:85227636 C/T cg11189052 chr15:85197271 WDR73 0.48 5.93 0.31 7.56e-9 Schizophrenia; LUSC cis rs6500602 0.964 rs62039173 chr16:4463846 G/A cg08645402 chr16:4508243 NA 0.51 8.42 0.42 1.15e-15 Schizophrenia; LUSC cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC trans rs4714291 0.963 rs1304602 chr6:40013471 T/G cg02267698 chr19:7991119 CTXN1 0.54 7.47 0.38 7.11e-13 Strep throat; LUSC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg22105103 chr4:187893119 NA 0.71 13.88 0.6 6.72e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 11.7 0.54 1.01e-26 Colorectal cancer; LUSC cis rs9633740 1.000 rs7097656 chr10:82250831 T/C cg01528321 chr10:82214614 TSPAN14 1.1 12.08 0.55 3.98e-28 Post bronchodilator FEV1; LUSC cis rs9457247 0.765 rs9295385 chr6:167448181 A/G cg25258033 chr6:167368657 RNASET2 0.46 6.71 0.34 8.33e-11 Crohn's disease; LUSC trans rs61931739 0.649 rs861526 chr12:33726434 A/G cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs11264213 0.901 rs72661632 chr1:36420715 G/A cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.39e-14 Schizophrenia; LUSC trans rs4811340 0.600 rs6068252 chr20:51180373 A/C cg15736553 chr3:11610338 VGLL4 0.34 6.13 0.32 2.54e-9 Thyroid peroxidase antibody positivity; LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 14.98 0.63 3.56e-39 Platelet count; LUSC cis rs55794721 0.509 rs6699896 chr1:25762902 A/T cg03538708 chr1:25844672 NA -0.35 -5.69 -0.3 2.74e-8 Plateletcrit;Mean corpuscular volume; LUSC cis rs67072384 1.000 rs55957377 chr11:72445476 A/G cg04827223 chr11:72435913 ARAP1 -0.82 -7.76 -0.39 1.04e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs1371867 0.846 rs959022 chr8:101295992 T/A cg00191853 chr8:101177733 SPAG1 -0.41 -6.56 -0.34 2.08e-10 Atrioventricular conduction; LUSC cis rs4363385 0.510 rs61811886 chr1:153035743 G/A cg25856811 chr1:152973957 SPRR3 -0.38 -6.2 -0.32 1.63e-9 Inflammatory skin disease; LUSC cis rs10743315 0.778 rs10841184 chr12:19370768 T/G cg02471346 chr12:19282374 PLEKHA5 -0.53 -6.68 -0.34 1.01e-10 Gut microbiota (bacterial taxa); LUSC cis rs7937682 0.855 rs7934922 chr11:111500026 T/C cg22437258 chr11:111473054 SIK2 0.52 7.03 0.36 1.2e-11 Primary sclerosing cholangitis; LUSC cis rs13223928 0.536 rs12700594 chr7:3156701 G/A cg19214707 chr7:3157722 NA 0.44 9.04 0.44 1.33e-17 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.9 -0.31 8.87e-9 Total body bone mineral density; LUSC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg13206674 chr6:150067644 NUP43 0.59 9.34 0.46 1.37e-18 Lung cancer; LUSC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg19077165 chr18:44547161 KATNAL2 -0.45 -6.75 -0.35 6.74e-11 Personality dimensions; LUSC cis rs4285028 0.747 rs58367397 chr3:121451700 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.86 -0.58 5.27e-31 Multiple sclerosis; LUSC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg08219700 chr8:58056026 NA 0.5 6.18 0.32 1.84e-9 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.537 rs1790101 chr12:123704844 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs8099014 1.000 rs4384676 chr18:56125973 T/A cg12907477 chr18:56117327 MIR122 0.43 6.86 0.35 3.44e-11 Platelet count; LUSC cis rs10751667 0.961 rs7396670 chr11:929269 A/G cg06064525 chr11:970664 AP2A2 -0.36 -7.17 -0.37 4.88e-12 Alzheimer's disease (late onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00815440 chr19:29704028 UQCRFS1 -0.41 -6.0 -0.31 5.1e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg13149276 chr1:160232740 DCAF8 0.41 6.16 0.32 2.14e-9 Triglycerides; LUSC trans rs853679 0.517 rs9283884 chr6:28135660 C/G cg06606381 chr12:133084897 FBRSL1 0.45 6.05 0.31 3.89e-9 Depression; LUSC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg21880101 chr17:80066754 CCDC57 -0.31 -5.8 -0.3 1.54e-8 Life satisfaction; LUSC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg13319975 chr6:146136371 FBXO30 -0.53 -7.83 -0.39 6.65e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.935 rs739239 chr22:50050468 G/A cg10356904 chr22:49881777 NA -0.33 -7.3 -0.37 2.15e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6121246 0.567 rs6060260 chr20:30192907 C/T cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC trans rs2898290 0.622 rs1600250 chr8:11345425 A/C cg15556689 chr8:8085844 FLJ10661 -0.54 -8.37 -0.42 1.6e-15 Systolic blood pressure; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.34 0.56 4.44e-29 Prudent dietary pattern; LUSC cis rs6558174 0.965 rs7831119 chr8:22489678 C/T cg03733263 chr8:22462867 KIAA1967 -0.46 -6.27 -0.32 1.12e-9 Breast cancer; LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg21782813 chr7:2030301 MAD1L1 0.45 7.41 0.38 1.02e-12 Bipolar disorder and schizophrenia; LUSC cis rs2439831 0.867 rs28415933 chr15:43635800 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 4.03e-19 Lung cancer in ever smokers; LUSC cis rs34779708 0.966 rs4934536 chr10:35441169 A/G cg03585969 chr10:35415529 CREM 0.6 8.77 0.43 9.27e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs73001065 0.551 rs79954596 chr19:19548643 T/G cg03709012 chr19:19516395 GATAD2A 0.97 9.4 0.46 8.69e-19 LDL cholesterol; LUSC cis rs80130819 0.515 rs1635536 chr12:48385945 A/G cg24011408 chr12:48396354 COL2A1 0.54 6.7 0.34 8.61e-11 Prostate cancer; LUSC cis rs7789940 0.904 rs73140040 chr7:75936240 C/T cg15798862 chr7:76129360 DTX2 -0.47 -7.67 -0.39 1.96e-13 Multiple sclerosis; LUSC cis rs7091068 0.616 rs7093903 chr10:95484010 C/T cg20715218 chr10:95462985 C10orf4 -0.6 -6.81 -0.35 4.55e-11 Urinary tract infection frequency; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg09436375 chr6:42928200 GNMT -0.29 -6.76 -0.35 6.23e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09974566 chr22:32150118 DEPDC5 0.43 6.12 0.32 2.68e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg16362232 chr11:430036 ANO9 0.7 8.64 0.43 2.3e-16 Body mass index; LUSC trans rs208515 0.525 rs12214310 chr6:66666308 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.03 14.08 0.61 1.14e-35 Exhaled nitric oxide levels; LUSC trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg08313168 chr12:7315531 NA 0.48 6.15 0.32 2.2e-9 Lung disease severity in cystic fibrosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07920855 chr1:185286635 IVNS1ABP 0.37 6.01 0.31 4.9e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg15147215 chr3:52552868 STAB1 -0.3 -5.91 -0.31 8.67e-9 Bipolar disorder; LUSC cis rs80282103 0.867 rs13377037 chr10:1068639 C/T cg18964960 chr10:1102726 WDR37 0.62 6.02 0.31 4.72e-9 Glomerular filtration rate (creatinine); LUSC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg00033643 chr7:134001901 SLC35B4 0.46 7.18 0.37 4.54e-12 Mean platelet volume; LUSC cis rs4919687 0.577 rs12765459 chr10:104465687 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -6.02 -0.31 4.64e-9 Colorectal cancer; LUSC cis rs425277 0.958 rs262688 chr1:2113565 T/G cg03732007 chr1:2071316 PRKCZ 0.46 7.48 0.38 6.51e-13 Height; LUSC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg24531977 chr5:56204891 C5orf35 -0.58 -8.68 -0.43 1.83e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs9443645 0.507 rs1475046 chr6:79461801 G/A cg05283184 chr6:79620031 NA -0.37 -7.01 -0.36 1.36e-11 Intelligence (multi-trait analysis); LUSC cis rs6942756 0.774 rs2402944 chr7:128951402 G/T cg02491457 chr7:128862824 NA -0.47 -7.18 -0.37 4.5e-12 White matter hyperintensity burden; LUSC cis rs73198271 0.653 rs10087742 chr8:8660474 A/G cg01851573 chr8:8652454 MFHAS1 0.48 8.18 0.41 6.19e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9325144 0.560 rs7971313 chr12:38653413 A/G cg26384229 chr12:38710491 ALG10B -0.67 -10.52 -0.5 1.46e-22 Morning vs. evening chronotype; LUSC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg09904177 chr6:26538194 HMGN4 0.47 7.47 0.38 7.28e-13 Schizophrenia; LUSC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg05347473 chr6:146136440 FBXO30 -0.58 -10.06 -0.48 5.68e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg14830002 chr1:247616686 OR2B11 -0.52 -7.95 -0.4 2.99e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs9420 0.961 rs7121169 chr11:57452543 G/A cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.18e-10 Schizophrenia; LUSC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12756686 chr19:29218302 NA 0.72 10.91 0.51 6.58e-24 Methadone dose in opioid dependence; LUSC cis rs6060717 0.536 rs6058356 chr20:34491530 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.67 -0.3 3.14e-8 Hip circumference adjusted for BMI; LUSC cis rs983392 0.679 rs1530914 chr11:60028940 C/T cg24026212 chr11:59952134 MS4A6A 0.36 6.23 0.32 1.41e-9 Alzheimer's disease (late onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18187726 chr12:69080414 NUP107 0.43 6.22 0.32 1.47e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg13628971 chr7:2884303 GNA12 0.46 6.91 0.35 2.48e-11 Height; LUSC cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg06022373 chr22:39101656 GTPBP1 0.74 11.4 0.53 1.17e-25 Menopause (age at onset); LUSC cis rs34779708 0.931 rs11597392 chr10:35288575 T/C cg03585969 chr10:35415529 CREM 0.6 8.53 0.42 5.07e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg24675658 chr1:53192096 ZYG11B -0.7 -11.57 -0.53 2.96e-26 Monocyte count; LUSC cis rs11024102 1.000 rs4141194 chr11:17011176 A/C cg15084286 chr11:17036142 PLEKHA7 -0.43 -5.93 -0.31 7.61e-9 Glaucoma (primary angle closure); LUSC cis rs908922 0.887 rs1538084 chr1:152496012 A/C cg20991723 chr1:152506922 NA 0.52 8.67 0.43 1.94e-16 Hair morphology; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg14627760 chr17:79860435 NPB 0.39 6.18 0.32 1.86e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs1005277 0.579 rs2472173 chr10:38374638 G/A cg17830980 chr10:43048298 ZNF37B -0.59 -9.64 -0.47 1.44e-19 Extrinsic epigenetic age acceleration; LUSC cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs113835537 0.877 rs77239910 chr11:66329639 G/A cg24851651 chr11:66362959 CCS 0.5 6.13 0.32 2.41e-9 Airway imaging phenotypes; LUSC trans rs12406019 0.548 rs7524877 chr1:78615645 A/G cg20826526 chr3:156266748 SSR3 -0.45 -6.74 -0.35 7.04e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg08439880 chr3:133502540 NA -0.38 -6.83 -0.35 4.06e-11 Iron status biomarkers; LUSC cis rs3862435 0.706 rs2238323 chr15:90986403 G/A cg22089800 chr15:90895588 ZNF774 0.54 5.7 0.3 2.7e-8 Response to exercise (triglyceride level interaction); LUSC trans rs12310956 0.532 rs7967627 chr12:33974669 G/T cg26384229 chr12:38710491 ALG10B 0.69 10.78 0.51 1.84e-23 Morning vs. evening chronotype; LUSC cis rs7894407 0.760 rs1163072 chr10:105024378 C/T cg05636881 chr10:105038444 INA -0.35 -5.72 -0.3 2.38e-8 White matter hyperintensity burden; LUSC cis rs2730245 0.510 rs2788474 chr7:158649005 T/C cg14689365 chr7:158441557 NCAPG2 0.55 8.01 0.4 1.94e-14 Height; LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg19077165 chr18:44547161 KATNAL2 -0.38 -5.75 -0.3 1.98e-8 Personality dimensions; LUSC cis rs4589502 1.000 rs12440279 chr15:67133339 G/A cg12317470 chr15:67143691 NA 0.66 6.06 0.31 3.76e-9 Lung cancer (smoking interaction); LUSC cis rs2294693 0.945 rs2073015 chr6:41008747 A/G cg14769373 chr6:40998127 UNC5CL -0.54 -7.22 -0.37 3.59e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs34330 0.562 rs17212236 chr12:12855483 G/C cg09462578 chr12:12878428 APOLD1 -0.68 -7.89 -0.4 4.41e-14 Systemic lupus erythematosus; LUSC cis rs7712401 0.601 rs30067 chr5:122293668 A/T cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs1783925 1.000 rs1615640 chr11:125308076 C/G cg03464685 chr11:125439445 EI24 0.48 6.56 0.34 2.08e-10 Formal thought disorder in schizophrenia; LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.88 0.66 1.09e-42 Platelet count; LUSC cis rs7659604 0.521 rs4833773 chr4:122689245 C/T cg06713675 chr4:122721982 EXOSC9 0.37 5.95 0.31 6.9e-9 Type 2 diabetes; LUSC cis rs7829975 0.514 rs2920991 chr8:8259117 T/A cg15556689 chr8:8085844 FLJ10661 0.68 11.37 0.53 1.47e-25 Mood instability; LUSC cis rs679087 1.000 rs302317 chr12:29921443 G/A cg14258853 chr12:29935411 TMTC1 -1.0 -17.05 -0.68 2.48e-47 Schizophrenia; LUSC cis rs11098499 0.754 rs2036860 chr4:120248934 A/G cg09307838 chr4:120376055 NA 0.7 10.52 0.5 1.55e-22 Corneal astigmatism; LUSC cis rs10191773 0.535 rs56187472 chr2:113111668 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.65 -7.59 -0.38 3.16e-13 Yeast infection; LUSC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.8 -0.35 4.73e-11 Lung cancer; LUSC cis rs4843747 0.573 rs7499959 chr16:88110422 C/G cg09044154 chr16:88155775 NA -0.45 -6.49 -0.33 3.18e-10 Menopause (age at onset); LUSC cis rs11155671 0.530 rs4870080 chr6:150202644 T/C cg09699651 chr6:150184138 LRP11 0.44 6.97 0.36 1.74e-11 Testicular germ cell tumor; LUSC cis rs7590720 0.819 rs6435931 chr2:216892754 C/G cg12620499 chr2:216877984 MREG 0.91 15.73 0.65 4.16e-42 Alcohol dependence; LUSC cis rs478304 0.934 rs474483 chr11:65520060 T/G cg08755490 chr11:65554678 OVOL1 0.4 5.83 0.3 1.31e-8 Acne (severe); LUSC cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg18876405 chr7:65276391 NA -0.74 -12.97 -0.58 1.92e-31 Aortic root size; LUSC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7428 0.527 rs4459734 chr2:85547429 G/T cg24342717 chr2:85555507 TGOLN2 -0.74 -12.3 -0.56 6.28e-29 Ear protrusion; LUSC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg03433033 chr1:76189801 ACADM 0.8 12.74 0.57 1.38e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg05347473 chr6:146136440 FBXO30 0.59 9.69 0.47 9.97e-20 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs56056630 chr12:34543465 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC trans rs11098499 0.954 rs10014845 chr4:120301077 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg05528280 chr10:464225 DIP2C 0.37 5.73 0.3 2.24e-8 Psychosis in Alzheimer's disease; LUSC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg15369054 chr17:80825471 TBCD -0.58 -9.74 -0.47 6.79e-20 Breast cancer; LUSC cis rs12549902 1.000 rs12549902 chr8:41509259 C/T cg21772509 chr8:41503840 NKX6-3 0.66 11.32 0.53 2.26e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs1595825 0.891 rs16826873 chr2:198898222 A/C cg00982548 chr2:198649783 BOLL 0.53 6.83 0.35 4.02e-11 Ulcerative colitis; LUSC cis rs1538970 0.816 rs868351 chr1:46009818 G/T cg05343316 chr1:45956843 TESK2 0.69 9.5 0.46 4.35e-19 Platelet count; LUSC cis rs7904368 0.754 rs7091240 chr10:16855683 G/A cg14835575 chr10:16859367 RSU1 0.71 9.05 0.44 1.18e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs4356932 1.000 rs4859595 chr4:76950062 C/T cg00809888 chr4:76862425 NAAA 0.35 5.74 0.3 2.07e-8 Blood protein levels; LUSC cis rs1997103 1.000 rs6958664 chr7:55404958 T/G cg17469321 chr7:55412551 NA 0.66 10.62 0.5 6.87e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25134081 chr14:64931936 AKAP5 -1.01 -8.5 -0.42 6.57e-16 Cognitive performance; LUSC cis rs9920506 0.536 rs11072768 chr15:78929478 A/C cg05914723 chr15:78953907 NA -0.34 -5.69 -0.3 2.8e-8 Post bronchodilator FEV1; LUSC trans rs6601327 0.641 rs10102170 chr8:9611470 C/T cg06636001 chr8:8085503 FLJ10661 0.44 5.95 0.31 6.68e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs7726839 0.561 rs11955068 chr5:582324 C/T cg11887960 chr12:57824829 NA 0.48 6.47 0.33 3.46e-10 Obesity-related traits; LUSC cis rs9486719 0.948 rs11152970 chr6:96909077 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.81e-20 Migraine;Coronary artery disease; LUSC cis rs2236918 0.710 rs1635510 chr1:242027500 G/T cg17736920 chr1:242011382 EXO1 0.4 6.37 0.33 6.43e-10 Menopause (age at onset); LUSC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg09359103 chr1:154839909 KCNN3 -0.73 -17.8 -0.7 2.59e-50 Prostate cancer; LUSC cis rs9902453 0.967 rs4473252 chr17:28454423 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.19 0.41 5.57e-15 Coffee consumption (cups per day); LUSC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg07424592 chr7:64974309 NA 0.69 6.08 0.32 3.28e-9 Diabetic kidney disease; LUSC cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.51 -0.42 5.93e-16 Chronic sinus infection; LUSC cis rs9296092 0.517 rs62405949 chr6:33522800 G/A cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.77e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs6906287 0.647 rs10457338 chr6:118784018 T/C cg21191810 chr6:118973309 C6orf204 0.33 6.0 0.31 5.17e-9 Electrocardiographic conduction measures; LUSC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg18681998 chr4:17616180 MED28 0.84 15.29 0.64 2.27e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg25566285 chr7:158114605 PTPRN2 0.31 5.74 0.3 2.15e-8 Calcium levels; LUSC cis rs2108225 0.900 rs7805114 chr7:107450033 G/T cg18560240 chr7:107437656 SLC26A3 0.41 6.31 0.33 8.65e-10 Ulcerative colitis; LUSC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.91 -0.31 8.53e-9 Tonsillectomy; LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.81 -0.35 4.6e-11 Menopause (age at onset); LUSC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 1.95e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12541635 0.677 rs1496180 chr8:106973877 T/G cg10147462 chr8:107024639 NA 0.64 12.92 0.58 3.03e-31 Age of smoking initiation; LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.54e-11 Developmental language disorder (linguistic errors); LUSC cis rs858239 0.601 rs10263110 chr7:23160551 G/A cg23682824 chr7:23144976 KLHL7 0.39 5.69 0.3 2.85e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7584330 0.554 rs7587496 chr2:238387632 A/G cg14458575 chr2:238380390 NA 0.69 8.22 0.41 4.52e-15 Prostate cancer; LUSC cis rs11711311 1.000 rs2305546 chr3:113503354 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.62 0.34 1.4e-10 IgG glycosylation; LUSC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg06494592 chr3:125709126 NA -0.52 -5.85 -0.3 1.16e-8 Blood pressure (smoking interaction); LUSC cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg21770322 chr7:97807741 LMTK2 0.39 6.89 0.35 2.72e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9287719 0.649 rs58633964 chr2:10736382 T/G cg00105475 chr2:10696890 NA 0.39 6.3 0.33 9.37e-10 Prostate cancer; LUSC trans rs2204008 0.687 rs1733404 chr12:38123395 G/T cg06521331 chr12:34319734 NA 0.42 6.67 0.34 1.06e-10 Bladder cancer; LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg08280861 chr8:58055591 NA -0.57 -6.5 -0.33 2.99e-10 Developmental language disorder (linguistic errors); LUSC cis rs17125944 0.505 rs80211268 chr14:53265483 C/G cg00686598 chr14:53173677 PSMC6 1.21 11.24 0.52 4.31e-25 Alzheimer's disease (late onset); LUSC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg04414720 chr1:150670196 GOLPH3L 0.54 8.32 0.41 2.29e-15 Melanoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14065121 chr9:77643271 C9orf41 -0.48 -5.96 -0.31 6.29e-9 Bipolar disorder and schizophrenia; LUSC cis rs243505 0.660 rs3779037 chr7:148539323 T/C cg09806900 chr7:148480153 CUL1 0.49 6.44 0.33 4.23e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg11871910 chr12:69753446 YEATS4 0.68 10.47 0.5 2.28e-22 Blood protein levels; LUSC cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg24531977 chr5:56204891 C5orf35 -0.86 -13.82 -0.6 1.11e-34 Initial pursuit acceleration; LUSC cis rs1808579 0.935 rs2510344 chr18:21113285 C/T cg14672496 chr18:21087552 C18orf8 -0.33 -5.65 -0.3 3.44e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg24829409 chr8:58192753 C8orf71 -0.59 -6.49 -0.33 3.04e-10 Developmental language disorder (linguistic errors); LUSC cis rs12190007 0.573 rs3006218 chr6:169868769 G/A ch.6.169577133F chr6:169835210 NA -0.4 -6.03 -0.31 4.38e-9 Obesity-related traits; LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg25036284 chr2:26402008 FAM59B -0.68 -9.4 -0.46 9.11e-19 Gut microbiome composition (summer); LUSC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg25456477 chr12:86230367 RASSF9 0.4 6.92 0.35 2.34e-11 Major depressive disorder; LUSC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg06212747 chr3:49208901 KLHDC8B 0.44 5.78 0.3 1.69e-8 Parkinson's disease; LUSC cis rs1878931 0.580 rs4578649 chr16:3407258 C/T cg22508957 chr16:3507546 NAT15 0.36 5.87 0.31 1.03e-8 Body mass index (adult); LUSC cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg08999081 chr20:33150536 PIGU 0.52 10.35 0.49 5.86e-22 Glomerular filtration rate (creatinine); LUSC cis rs12291225 0.679 rs4757245 chr11:14297872 A/C cg05501817 chr11:14380813 RRAS2 -0.57 -8.9 -0.44 3.72e-17 Sense of smell; LUSC trans rs62238980 0.614 rs4821015 chr22:32402549 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs9815354 0.812 rs73071356 chr3:41829486 C/T cg03022575 chr3:42003672 ULK4 0.85 8.62 0.43 2.78e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg18230493 chr5:56204884 C5orf35 -0.89 -13.72 -0.6 2.68e-34 Initial pursuit acceleration; LUSC cis rs17270561 0.636 rs1165157 chr6:25792250 A/G cg16482183 chr6:26056742 HIST1H1C 0.53 7.53 0.38 4.66e-13 Iron status biomarkers; LUSC cis rs9325144 0.647 rs61937754 chr12:39060543 T/C cg26384229 chr12:38710491 ALG10B -0.62 -9.56 -0.46 2.74e-19 Morning vs. evening chronotype; LUSC trans rs6951245 0.744 rs10265736 chr7:1172465 C/T cg13565492 chr6:43139072 SRF -0.57 -6.68 -0.34 1.03e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg22920501 chr2:26401640 FAM59B -0.74 -10.07 -0.48 5.45e-21 Gut microbiome composition (summer); LUSC cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg00321850 chr1:175162397 KIAA0040 -0.44 -7.58 -0.38 3.4e-13 Alcohol dependence; LUSC cis rs9611519 1.000 rs9611519 chr22:41613188 C/T cg03806693 chr22:41940476 POLR3H -0.54 -7.39 -0.37 1.18e-12 Neuroticism; LUSC trans rs9929218 0.953 rs3118235 chr16:68732977 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.8 12.24 0.56 1.05e-28 Colorectal cancer; LUSC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg15556689 chr8:8085844 FLJ10661 0.57 9.0 0.44 1.76e-17 Retinal vascular caliber; LUSC trans rs459571 0.959 rs2520100 chr9:136918137 A/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.43 -6.22 -0.32 1.47e-9 Platelet distribution width; LUSC trans rs4911259 0.552 rs11700082 chr20:31460244 A/G cg09781936 chr22:19749961 TBX1 -0.34 -6.02 -0.31 4.72e-9 Inflammatory bowel disease; LUSC cis rs200367988 1 rs200367988 chr10:122674849 G/A cg14149699 chr10:122610679 WDR11 -0.46 -7.01 -0.36 1.29e-11 Prostate-specific antigen levels (conditioned on lead SNPs);Prostate-specific antigen levels; LUSC cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg18850929 chr19:1828978 REXO1 -0.42 -6.19 -0.32 1.78e-9 Bipolar disorder; LUSC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg08270630 chr22:50330655 NA -0.43 -6.42 -0.33 4.8e-10 Schizophrenia; LUSC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg03036452 chr22:46663545 TTC38 0.54 5.82 0.3 1.41e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs28735056 0.609 rs4799099 chr18:77639585 A/G cg05926928 chr17:57297772 GDPD1 0.62 8.69 0.43 1.59e-16 Schizophrenia; LUSC cis rs62400317 0.762 rs1329711 chr6:44963401 A/G cg18551225 chr6:44695536 NA -0.43 -6.96 -0.36 1.76e-11 Total body bone mineral density; LUSC cis rs4363385 0.510 rs61811886 chr1:153035743 G/A cg00922841 chr1:152955080 SPRR1A -0.37 -6.11 -0.32 2.84e-9 Inflammatory skin disease; LUSC cis rs360798 0.532 rs1553832 chr2:63013515 C/G cg17519650 chr2:63277830 OTX1 -0.52 -7.3 -0.37 2.16e-12 Coronary artery disease; LUSC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.63e-10 Life satisfaction; LUSC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg23649088 chr2:200775458 C2orf69 0.53 7.25 0.37 2.9e-12 Schizophrenia; LUSC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.2 16.31 0.67 2.22e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6964587 1.000 rs7797369 chr7:91570615 C/A cg17063962 chr7:91808500 NA -0.58 -9.19 -0.45 4.34e-18 Breast cancer; LUSC cis rs1595825 0.945 rs7426250 chr2:198837358 G/A cg00982548 chr2:198649783 BOLL -0.57 -7.13 -0.36 6.43e-12 Ulcerative colitis; LUSC cis rs10743315 0.557 rs74465549 chr12:19344365 A/C cg02471346 chr12:19282374 PLEKHA5 0.69 5.74 0.3 2.09e-8 Gut microbiota (bacterial taxa); LUSC cis rs920590 0.721 rs61180388 chr8:19670214 G/C cg03894339 chr8:19674705 INTS10 0.55 7.65 0.39 2.22e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs804280 0.509 rs9886639 chr8:11784529 G/T cg14343924 chr8:8086146 FLJ10661 0.45 6.31 0.33 9.04e-10 Myopia (pathological); LUSC cis rs1577917 0.654 rs9450284 chr6:86199329 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.38 6.21 0.32 1.6e-9 Response to antipsychotic treatment; LUSC trans rs459571 0.959 rs455381 chr9:136905577 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.76 -12.5 -0.56 1.17e-29 Platelet distribution width; LUSC cis rs11690462 0.817 rs7571948 chr2:26542155 C/A cg26119090 chr2:26468346 HADHA;HADHB 0.48 6.17 0.32 2.03e-9 Coronary artery disease; LUSC cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.76 0.35 6.23e-11 Educational attainment; LUSC cis rs3744061 0.569 rs2240769 chr17:74718155 C/T cg27546012 chr17:74684504 MXRA7 -0.46 -7.68 -0.39 1.75e-13 Retinal arteriolar caliber; LUSC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg21918786 chr6:109611834 NA -0.42 -7.36 -0.37 1.41e-12 Reticulocyte fraction of red cells; LUSC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg22823121 chr1:150693482 HORMAD1 0.59 9.09 0.45 9.12e-18 Tonsillectomy; LUSC cis rs12286929 0.607 rs10891808 chr11:115071301 T/C cg04055981 chr11:115044050 NA -0.42 -7.51 -0.38 5.28e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9296095 1.000 rs5745582 chr6:33546498 C/T cg14003231 chr6:33640908 ITPR3 0.46 7.16 0.36 5.28e-12 Platelet count; LUSC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg14440974 chr22:39074834 NA -0.38 -6.37 -0.33 6.2e-10 Menopause (age at onset); LUSC cis rs7215564 0.908 rs2316061 chr17:78663660 A/G cg09596252 chr17:78655493 RPTOR 0.54 5.87 0.31 1.04e-8 Myopia (pathological); LUSC cis rs983392 0.679 rs600064 chr11:60013451 A/G cg02771260 chr11:59836817 MS4A3 0.37 6.16 0.32 2.12e-9 Alzheimer's disease (late onset); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg11829371 chr17:981724 ABR 0.45 6.1 0.32 2.95e-9 Neuroticism; LUSC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg11859384 chr17:80120422 CCDC57 0.36 5.65 0.3 3.4e-8 Life satisfaction; LUSC cis rs6547741 1.000 rs1080060 chr2:27768808 T/A cg27432699 chr2:27873401 GPN1 0.79 14.87 0.63 9.46e-39 Oral cavity cancer; LUSC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg06238570 chr21:40685208 BRWD1 0.48 7.37 0.37 1.34e-12 Cognitive function; LUSC cis rs9650315 0.586 rs13249464 chr8:57208233 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.64 7.8 0.39 7.83e-14 Height; LUSC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg25019033 chr10:957182 NA -0.49 -6.3 -0.33 9.18e-10 Eosinophil percentage of granulocytes; LUSC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg06808227 chr14:105710500 BRF1 -0.67 -10.31 -0.49 8.31e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg23711669 chr6:146136114 FBXO30 0.76 13.72 0.6 2.65e-34 Lobe attachment (rater-scored or self-reported); LUSC trans rs2727020 0.612 rs9787891 chr11:49413494 G/A cg03929089 chr4:120376271 NA -0.83 -12.09 -0.55 3.76e-28 Coronary artery disease; LUSC cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.38 0.49 4.53e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.45 -8.2 -0.41 5.2e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg26441486 chr22:50317300 CRELD2 -0.54 -8.21 -0.41 4.86e-15 Schizophrenia; LUSC trans rs9929218 0.551 rs2296408 chr16:68713823 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -1.07 -25.35 -0.81 7.98e-80 Colorectal cancer; LUSC cis rs7917772 0.582 rs4285804 chr10:104386309 T/A cg22532475 chr10:104410764 TRIM8 0.26 6.2 0.32 1.64e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09713877 chr2:85198553 KCMF1 -0.42 -6.38 -0.33 6e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC trans rs1147199 0.585 rs2579375 chr9:87261958 T/C cg18287975 chr5:88178977 MEF2C 0.72 6.13 0.32 2.45e-9 Body mass index; LUSC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg13390004 chr1:15929781 NA 0.42 6.98 0.36 1.61e-11 Systolic blood pressure; LUSC cis rs317689 0.819 rs317685 chr12:69715457 A/G cg14784868 chr12:69753453 YEATS4 -0.44 -5.69 -0.3 2.84e-8 Response to diuretic therapy; LUSC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg17252645 chr8:143867129 LY6D -0.54 -10.28 -0.49 1.02e-21 Urinary tract infection frequency; LUSC cis rs634534 0.562 rs642293 chr11:65730217 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.65 0.47 1.35e-19 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg08477640 chr19:41863820 B9D2 -0.44 -6.72 -0.35 7.69e-11 Migraine;Coronary artery disease; LUSC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg25838465 chr1:92012736 NA -0.76 -15.54 -0.65 2.24e-41 Breast cancer; LUSC trans rs208520 1.000 rs12193164 chr6:66978962 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg13683864 chr3:40499215 RPL14 -1.0 -16.94 -0.68 6.89e-47 Renal cell carcinoma; LUSC cis rs17014483 0.749 rs2860408 chr4:89639032 A/G cg01026744 chr4:89619053 NAP1L5;HERC3 0.69 6.08 0.32 3.28e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7216064 1.000 rs6504549 chr17:65888784 A/G cg12091567 chr17:66097778 LOC651250 -0.71 -9.53 -0.46 3.27e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.77 -11.14 -0.52 1.05e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg11984989 chr7:158649758 WDR60 1.06 21.01 0.75 4.78e-63 Height; LUSC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC trans rs10506458 1.000 rs11174759 chr12:63444363 A/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -15.62 -0.65 1.1e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg16524733 chr11:117070046 TAGLN 0.3 5.73 0.3 2.2e-8 Blood protein levels; LUSC cis rs17270561 0.609 rs1892248 chr6:25768914 C/T cg17691542 chr6:26056736 HIST1H1C 0.52 7.08 0.36 8.65e-12 Iron status biomarkers; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00923919 chr22:26879581 HPS4;SRRD -0.4 -6.29 -0.33 9.96e-10 Electrocardiographic conduction measures; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg23558158 chr2:220094171 ANKZF1;ATG9A 0.39 6.05 0.31 3.84e-9 Educational attainment (years of education); LUSC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg02275930 chr1:2372054 NA -0.54 -7.85 -0.39 5.56e-14 Non-obstructive azoospermia; LUSC cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.92 0.31 7.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.84 -0.3 1.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9905704 0.633 rs2680687 chr17:56491966 T/C cg19466818 chr17:56409534 MIR142 -0.32 -5.88 -0.31 1e-8 Testicular germ cell tumor; LUSC cis rs1448094 0.935 rs11117119 chr12:86336432 A/T cg02569458 chr12:86230093 RASSF9 0.42 6.68 0.34 9.91e-11 Major depressive disorder; LUSC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 6.11 0.32 2.7e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7568458 0.837 rs35215812 chr2:85792384 G/A cg17127132 chr2:85788382 GGCX 0.47 7.6 0.38 3.01e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.21 0.41 4.74e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs561341 0.882 rs563539 chr17:30307958 A/G cg27661571 chr11:113659931 NA -0.6 -7.26 -0.37 2.74e-12 Hip circumference adjusted for BMI; LUSC cis rs1044826 0.642 rs9826544 chr3:139162831 A/G cg00490450 chr3:139108681 COPB2 0.49 7.74 0.39 1.18e-13 Obesity-related traits; LUSC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg07936489 chr17:37558343 FBXL20 -0.7 -9.79 -0.47 4.75e-20 Glomerular filtration rate (creatinine); LUSC cis rs6484504 0.600 rs208063 chr11:31159777 C/T cg26647111 chr11:31128758 NA -0.41 -6.05 -0.31 3.84e-9 Red blood cell count; LUSC trans rs724744 0.772 rs1772078 chr6:22353844 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.19 -0.32 1.77e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg01341218 chr17:43662625 NA 0.77 11.18 0.52 7.31e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs4650994 0.525 rs4316329 chr1:178509333 C/T cg05059571 chr16:84539110 KIAA1609 -0.47 -9.02 -0.44 1.55e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg09877947 chr5:131593287 PDLIM4 -0.37 -6.0 -0.31 5.25e-9 Blood metabolite levels; LUSC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg09034736 chr1:150693464 HORMAD1 0.49 7.1 0.36 7.45e-12 Tonsillectomy; LUSC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg15448220 chr1:150897856 SETDB1 0.42 5.95 0.31 6.69e-9 Melanoma; LUSC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -6.93 -0.35 2.21e-11 Electroencephalogram traits; LUSC cis rs9303401 0.659 rs11079358 chr17:56920949 G/T cg25039879 chr17:56429692 SUPT4H1 0.67 8.95 0.44 2.48e-17 Cognitive test performance; LUSC cis rs2637266 1.000 rs7082587 chr10:78386328 C/T cg18941641 chr10:78392320 NA 0.4 7.33 0.37 1.79e-12 Pulmonary function; LUSC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg18230493 chr5:56204884 C5orf35 -0.94 -13.79 -0.6 1.43e-34 Initial pursuit acceleration; LUSC cis rs9921338 0.961 rs55707838 chr16:11378075 C/T cg00044050 chr16:11439710 C16orf75 -0.5 -6.97 -0.36 1.74e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2692947 0.800 rs4332959 chr2:96549121 C/T cg23100626 chr2:96804247 ASTL 0.25 5.95 0.31 6.87e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1775715 0.678 rs2778649 chr10:32146803 C/G cg03015672 chr10:32216066 ARHGAP12 0.36 6.46 0.33 3.77e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg06212747 chr3:49208901 KLHDC8B 0.43 5.83 0.3 1.33e-8 Parkinson's disease; LUSC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg21724239 chr8:58056113 NA 0.85 9.53 0.46 3.26e-19 Developmental language disorder (linguistic errors); LUSC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg04362960 chr10:104952993 NT5C2 0.59 9.39 0.46 1e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs597583 0.664 rs4938395 chr11:117384673 C/T cg27161313 chr11:117392002 DSCAML1 0.47 7.78 0.39 9.25e-14 Putamen volume; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13826618 chr2:11828697 NA -0.41 -6.05 -0.31 3.8e-9 Hepatitis; LUSC cis rs2197308 0.765 rs12370231 chr12:37917881 T/C cg26384229 chr12:38710491 ALG10B 0.94 16.03 0.66 2.61e-43 Morning vs. evening chronotype; LUSC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg18876405 chr7:65276391 NA 0.68 12.13 0.55 2.6e-28 Aortic root size; LUSC cis rs9399401 0.961 rs6570509 chr6:142716286 G/T cg03128060 chr6:142623767 GPR126 0.33 6.0 0.31 5.15e-9 Chronic obstructive pulmonary disease; LUSC trans rs2204008 0.715 rs11495369 chr12:38238673 T/C cg06521331 chr12:34319734 NA -0.4 -6.16 -0.32 2.14e-9 Bladder cancer; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.49 -8.47 -0.42 8.09e-16 Lymphocyte counts; LUSC cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg25173405 chr17:45401733 C17orf57 0.36 5.72 0.3 2.36e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.47 -0.33 3.44e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1953600 0.870 rs2245168 chr10:81921918 T/C cg04850286 chr10:81895943 PLAC9 -0.33 -5.72 -0.3 2.32e-8 Sarcoidosis; LUSC cis rs9549260 0.816 rs7328594 chr13:41253764 T/C cg21288729 chr13:41239152 FOXO1 0.57 8.5 0.42 6.36e-16 Red blood cell count; LUSC cis rs614226 0.938 rs787824 chr12:120924638 A/G cg01236616 chr12:121019343 POP5 -1.26 -20.29 -0.74 3.29e-60 Type 1 diabetes nephropathy; LUSC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg11941060 chr3:133502564 NA -0.62 -9.91 -0.48 1.88e-20 Iron status biomarkers; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg02018176 chr4:1364513 KIAA1530 0.5 8.93 0.44 2.9e-17 Obesity-related traits; LUSC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg05890377 chr2:74357713 NA 0.75 14.26 0.62 2.24e-36 Gestational age at birth (maternal effect); LUSC cis rs4901869 0.966 rs12878614 chr14:59339477 A/C cg02291164 chr14:59296302 NA 0.58 11.11 0.52 1.31e-24 Panic disorder; LUSC cis rs2271400 0.547 rs167999 chr8:56792685 G/A cg08894788 chr8:56792171 LYN -0.43 -5.88 -0.31 1e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Myeloid white cell count;Neutrophil count;Granulocyte count; LUSC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg18876405 chr7:65276391 NA 0.54 8.62 0.43 2.72e-16 Aortic root size; LUSC cis rs7553864 0.574 rs6576867 chr1:87615796 A/T cg17420885 chr1:87600446 LOC339524 -0.52 -6.98 -0.36 1.57e-11 Smoking behavior; LUSC cis rs6430585 0.941 rs12469551 chr2:136510012 T/G cg07169764 chr2:136633963 MCM6 -0.85 -11.71 -0.54 8.79e-27 Corneal structure; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27537453 chr16:2732578 KCTD5 0.47 6.65 0.34 1.19e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.679 rs16921687 chr8:58053514 T/C cg22535103 chr8:58192502 C8orf71 -0.57 -6.54 -0.34 2.29e-10 Developmental language disorder (linguistic errors); LUSC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg02428538 chr16:24856791 SLC5A11 -0.52 -5.8 -0.3 1.51e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs8060686 0.516 rs7193701 chr16:68185160 A/G cg06417522 chr17:66508098 PRKAR1A 0.44 6.13 0.32 2.46e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7192380 0.964 rs6499231 chr16:69588016 A/G cg26679644 chr16:69762563 NA 0.34 6.07 0.32 3.52e-9 Sjögren's syndrome; LUSC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.13e-12 Mean platelet volume; LUSC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg25039879 chr17:56429692 SUPT4H1 0.8 10.99 0.52 3.51e-24 Cognitive test performance; LUSC cis rs6696846 0.777 rs2369526 chr1:205054406 C/T cg00857998 chr1:205179979 DSTYK 0.57 8.98 0.44 1.99e-17 Red blood cell count; LUSC cis rs4654899 0.714 rs12401630 chr1:21495049 G/A cg01072550 chr1:21505969 NA -0.51 -7.55 -0.38 4.21e-13 Superior frontal gyrus grey matter volume; LUSC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg18827107 chr12:86230957 RASSF9 -0.47 -6.95 -0.36 1.94e-11 Major depressive disorder; LUSC cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg27446573 chr6:127587934 RNF146 0.92 15.28 0.64 2.43e-40 Breast cancer; LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg05368731 chr17:41323189 NBR1 0.93 15.97 0.66 4.83e-43 Menopause (age at onset); LUSC cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg16797656 chr11:68205561 LRP5 0.37 6.11 0.32 2.78e-9 Total body bone mineral density; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg24060327 chr5:131705240 SLC22A5 -0.54 -8.94 -0.44 2.71e-17 Acylcarnitine levels; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg17541715 chr7:1216824 NA -0.41 -6.36 -0.33 6.59e-10 Longevity;Endometriosis; LUSC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg07701084 chr6:150067640 NUP43 0.57 8.96 0.44 2.36e-17 Lung cancer; LUSC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg26597838 chr10:835615 NA 1.01 13.96 0.61 3.21e-35 Eosinophil percentage of granulocytes; LUSC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 14.51 0.62 2.45e-37 Platelet count; LUSC cis rs10875595 0.836 rs59933130 chr5:140667303 G/A cg24830062 chr5:140700576 TAF7 -0.51 -6.25 -0.32 1.23e-9 Pulmonary function decline; LUSC cis rs4654899 1.000 rs4654905 chr1:21509558 A/G cg01072550 chr1:21505969 NA -0.55 -8.49 -0.42 7e-16 Superior frontal gyrus grey matter volume; LUSC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg09796270 chr17:17721594 SREBF1 -0.43 -7.44 -0.38 8.5e-13 Total body bone mineral density; LUSC cis rs1030268 0.505 rs80305547 chr7:133259400 A/G cg10665199 chr7:133106180 EXOC4 0.63 7.12 0.36 6.59e-12 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg18876405 chr7:65276391 NA -0.53 -8.44 -0.42 9.69e-16 Aortic root size; LUSC cis rs225245 0.817 rs225273 chr17:33970935 A/T cg05299278 chr17:33885742 SLFN14 0.31 6.65 0.34 1.23e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs524023 0.958 rs11231825 chr11:64360274 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.33 -0.49 6.6e-22 Urate levels in obese individuals; LUSC trans rs9329221 0.905 rs13254263 chr8:10255181 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.23 -0.41 4.25e-15 Neuroticism; LUSC cis rs2425143 1.000 rs1118233 chr20:34228349 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -6.54 -0.34 2.27e-10 Blood protein levels; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.72 0.43 1.34e-16 Prudent dietary pattern; LUSC trans rs2204008 0.577 rs11520050 chr12:38051839 G/A cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.25e-9 Bladder cancer; LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg26659404 chr1:25747437 RHCE -0.28 -5.88 -0.31 1.01e-8 Erythrocyte sedimentation rate; LUSC cis rs11190604 1.000 rs11190570 chr10:102227702 G/C cg16342193 chr10:102329863 NA -0.34 -6.21 -0.32 1.57e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2295359 0.824 rs4655679 chr1:67599657 A/G cg03340356 chr1:67600835 NA -0.42 -6.71 -0.34 8.21e-11 Psoriasis; LUSC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg08219700 chr8:58056026 NA 0.66 7.9 0.4 3.96e-14 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.17 0.41 6.27e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg18240062 chr17:79603768 NPLOC4 0.57 9.8 0.47 4.17e-20 Eye color traits; LUSC cis rs34779708 0.931 rs7079205 chr10:35324619 C/T cg04310649 chr10:35416472 CREM -0.38 -5.69 -0.3 2.81e-8 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg04267008 chr7:1944627 MAD1L1 -0.55 -8.29 -0.41 2.82e-15 Bipolar disorder and schizophrenia; LUSC cis rs8017423 0.900 rs7141887 chr14:90705364 G/T cg04374321 chr14:90722782 PSMC1 0.73 11.56 0.53 3.22e-26 Mortality in heart failure; LUSC cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg27446573 chr6:127587934 RNF146 0.92 15.3 0.64 2.12e-40 Breast cancer; LUSC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg12463550 chr7:65579703 CRCP -0.55 -8.19 -0.41 5.77e-15 Aortic root size; LUSC cis rs1577917 0.958 rs11755642 chr6:86450066 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.64 -0.43 2.3e-16 Response to antipsychotic treatment; LUSC cis rs2012796 1.000 rs10450894 chr14:81825172 T/A cg02996355 chr14:81879375 NA 0.5 7.25 0.37 2.83e-12 Night sleep phenotypes; LUSC cis rs244731 0.920 rs244707 chr5:176555636 A/T cg16006841 chr5:176797999 RGS14 0.63 8.44 0.42 9.53e-16 Urate levels in lean individuals; LUSC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs354225 0.544 rs11902987 chr2:54805587 C/T cg01766943 chr2:54829624 SPTBN1 0.48 7.67 0.39 1.91e-13 Schizophrenia; LUSC cis rs713477 1.000 rs12888234 chr14:55911352 T/A cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC trans rs208520 0.837 rs208498 chr6:66931560 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -13.71 -0.6 2.88e-34 Exhaled nitric oxide output; LUSC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01788568 chr2:74154043 DGUOK -0.47 -6.96 -0.36 1.77e-11 Electrocardiographic conduction measures; LUSC trans rs7939886 0.844 rs12421584 chr11:55937410 G/A cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC trans rs330048 0.509 rs36111783 chr8:9145588 A/G cg15556689 chr8:8085844 FLJ10661 0.5 7.12 0.36 6.76e-12 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.45 0.38 8.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2522056 1.000 rs2522056 chr5:131801726 C/T cg24060327 chr5:131705240 SLC22A5 0.43 5.8 0.3 1.53e-8 Lymphocyte counts;Fibrinogen; LUSC cis rs2289583 0.503 rs113742359 chr15:75261643 A/G cg14664628 chr15:75095509 CSK 0.47 6.53 0.34 2.51e-10 Systemic lupus erythematosus; LUSC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg12292205 chr6:26970375 C6orf41 -0.51 -8.5 -0.42 6.5e-16 Schizophrenia; LUSC cis rs4400599 0.642 rs4072431 chr1:154167116 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.76 -0.3 1.87e-8 Platelet distribution width; LUSC cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg18302933 chr2:88491318 NA -0.32 -6.1 -0.32 2.91e-9 Response to metformin (IC50); LUSC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg21361702 chr7:150065534 REPIN1 0.46 6.29 0.33 1.01e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs654950 0.934 rs638859 chr1:42001444 A/G cg06885757 chr1:42089581 HIVEP3 0.41 7.72 0.39 1.41e-13 Airway imaging phenotypes; LUSC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs16867335 1.000 rs11887445 chr2:181490442 C/T cg23363182 chr2:181467187 NA -0.45 -5.91 -0.31 8.35e-9 Survival in rectal cancer; LUSC trans rs11148252 0.553 rs7999849 chr13:53249414 A/G cg18335740 chr13:41363409 SLC25A15 0.78 14.42 0.62 5.56e-37 Lewy body disease; LUSC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg06634786 chr22:41940651 POLR3H 0.51 6.12 0.32 2.59e-9 Vitiligo; LUSC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg06627628 chr2:24431161 ITSN2 -0.59 -7.06 -0.36 9.71e-12 Lymphocyte counts; LUSC cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.43e-28 Intelligence (multi-trait analysis); LUSC cis rs354225 0.597 rs4347868 chr2:54830616 G/A cg26097391 chr2:54893211 SPTBN1 0.42 6.35 0.33 6.91e-10 Schizophrenia; LUSC cis rs7178572 0.568 rs1602925 chr15:77685857 T/C cg22256960 chr15:77711686 NA -0.5 -7.92 -0.4 3.57e-14 Type 2 diabetes; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg10360139 chr7:1886902 MAD1L1 0.38 5.86 0.31 1.14e-8 Bipolar disorder and schizophrenia; LUSC cis rs6084875 0.840 rs1885357 chr20:4727427 G/A cg07258627 chr20:4721683 PRNT -0.32 -5.81 -0.3 1.43e-8 Systemic lupus erythematosus; LUSC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg05738196 chr6:26577821 NA 0.47 6.77 0.35 5.98e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg04369109 chr6:150039330 LATS1 -0.52 -7.5 -0.38 5.95e-13 Lung cancer; LUSC cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg01884057 chr2:25150051 NA 0.48 11.35 0.53 1.83e-25 Body mass index; LUSC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg13770153 chr20:60521292 NA 0.99 15.03 0.64 2.29e-39 Obesity-related traits; LUSC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg09455208 chr3:40491958 NA -0.54 -9.6 -0.47 1.96e-19 Renal cell carcinoma; LUSC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg08677398 chr8:58056175 NA 0.52 6.08 0.32 3.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs908922 0.676 rs7531317 chr1:152528439 A/C cg20991723 chr1:152506922 NA 0.49 9.22 0.45 3.33e-18 Hair morphology; LUSC trans rs564343 0.563 rs493320 chr11:65832367 C/A cg26701943 chr11:108369231 KDELC2 -0.46 -6.16 -0.32 2.1e-9 Obesity (early onset extreme); LUSC cis rs4660306 0.677 rs781062 chr1:45932738 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.41 5.66 0.3 3.22e-8 Homocysteine levels; LUSC cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg07274523 chr3:49395745 GPX1 0.61 9.4 0.46 9.27e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs12971120 0.891 rs2278159 chr18:72178161 T/C cg26446133 chr18:72167187 CNDP2 -0.76 -9.13 -0.45 6.5e-18 Refractive error; LUSC cis rs7769051 0.708 rs9483514 chr6:133228716 G/A cg07930552 chr6:133119739 C6orf192 0.59 6.85 0.35 3.5e-11 Type 2 diabetes nephropathy; LUSC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg24468199 chr11:65410028 SIPA1 -0.54 -7.66 -0.39 2.08e-13 Blood pressure (age interaction); LUSC cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg02747822 chr19:1826707 REXO1 -0.36 -5.78 -0.3 1.72e-8 Bipolar disorder; LUSC cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg08085267 chr17:45401833 C17orf57 -0.54 -8.54 -0.42 4.99e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg16434002 chr17:42200994 HDAC5 0.47 6.81 0.35 4.66e-11 Total body bone mineral density; LUSC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg16535667 chr11:65410126 SIPA1 -0.44 -5.86 -0.31 1.13e-8 Blood pressure (age interaction); LUSC cis rs9430161 0.611 rs72644043 chr1:11033051 T/A cg27631724 chr1:11040367 C1orf127 0.54 9.52 0.46 3.6e-19 Ewing sarcoma; LUSC cis rs870825 0.860 rs56180712 chr4:185600223 A/G cg04058563 chr4:185651563 MLF1IP 0.84 12.06 0.55 4.82e-28 Blood protein levels; LUSC cis rs6840360 0.615 rs6858483 chr4:152465509 C/T cg22705602 chr4:152727874 NA -0.32 -6.49 -0.33 3.05e-10 Intelligence (multi-trait analysis); LUSC cis rs4917300 0.605 rs4917279 chr8:143095690 C/T cg25363559 chr8:143086065 NA -0.32 -7.16 -0.36 5.06e-12 Amyotrophic lateral sclerosis; LUSC cis rs897080 0.515 rs698767 chr2:44576417 A/G cg00619915 chr2:44497795 NA -0.39 -5.72 -0.3 2.4e-8 Height; LUSC cis rs6906287 0.647 rs11153763 chr6:118938738 G/A cg21191810 chr6:118973309 C6orf204 0.32 5.97 0.31 6.09e-9 Electrocardiographic conduction measures; LUSC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.49 -0.33 3.09e-10 Lung cancer; LUSC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.2 -0.72 6.74e-56 Height; LUSC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg20135002 chr11:47629003 NA -0.49 -7.66 -0.39 2.06e-13 Subjective well-being; LUSC cis rs34779708 0.931 rs35126129 chr10:35452141 G/A cg04310649 chr10:35416472 CREM -0.42 -6.47 -0.33 3.51e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg05283184 chr6:79620031 NA -0.58 -12.44 -0.56 1.93e-29 Intelligence (multi-trait analysis); LUSC cis rs1728785 0.892 rs9928950 chr16:68557114 G/A cg02972257 chr16:68554789 NA 0.58 6.9 0.35 2.69e-11 Ulcerative colitis; LUSC trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg15704280 chr7:45808275 SEPT13 0.88 12.82 0.57 7.43e-31 Coronary artery disease; LUSC cis rs9549367 0.713 rs2146750 chr13:113822530 A/G cg18105134 chr13:113819100 PROZ 0.65 8.95 0.44 2.6e-17 Platelet distribution width; LUSC cis rs1865721 1.000 rs62089509 chr18:73194519 G/A cg26385618 chr18:73139727 C18orf62 -0.48 -8.07 -0.4 1.32e-14 Intelligence; LUSC cis rs73195822 0.667 rs55799214 chr12:111229700 G/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.37 0.33 6.43e-10 Itch intensity from mosquito bite; LUSC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.67 -10.62 -0.5 6.81e-23 Menarche (age at onset); LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg13560548 chr3:10150139 C3orf24 0.46 6.26 0.32 1.21e-9 Alzheimer's disease; LUSC cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg00677455 chr12:58241039 CTDSP2 0.5 7.49 0.38 6.04e-13 Intelligence (multi-trait analysis); LUSC trans rs12692738 0.526 rs355859 chr2:165629520 T/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8077577 0.895 rs13284 chr17:18112130 C/T cg16794390 chr17:18148240 FLII 0.41 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg00343986 chr7:65444356 GUSB 0.44 6.71 0.34 8.31e-11 Aortic root size; LUSC cis rs6577655 0.517 rs6983560 chr8:135584553 C/T cg17885191 chr8:135476712 NA -0.56 -7.5 -0.38 5.85e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg19748678 chr4:122722346 EXOSC9 0.72 10.95 0.51 4.7e-24 Type 2 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg21771171 chr6:692465 EXOC2 -0.45 -6.02 -0.31 4.6e-9 Hepatitis; LUSC cis rs8072100 0.840 rs56952963 chr17:45493826 T/C cg25173405 chr17:45401733 C17orf57 -0.37 -5.73 -0.3 2.21e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs16937 0.662 rs10900468 chr1:205163057 A/G cg00857998 chr1:205179979 DSTYK 0.46 6.45 0.33 4e-10 Schizophrenia; LUSC cis rs11105298 0.786 rs10858897 chr12:89922032 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.28 -0.37 2.35e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1045714 0.895 rs4721860 chr7:2639994 C/T cg24848437 chr7:2645542 IQCE 0.62 6.86 0.35 3.33e-11 Urate levels in lean individuals; LUSC trans rs61931739 0.534 rs6488189 chr12:33995865 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.26 0.41 3.54e-15 Morning vs. evening chronotype; LUSC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg14552801 chr7:65878734 NA -0.37 -5.73 -0.3 2.2e-8 Aortic root size; LUSC cis rs72960926 0.744 rs72964209 chr6:74861734 C/T cg03266952 chr6:74778945 NA -0.85 -7.25 -0.37 2.94e-12 Metabolite levels (MHPG); LUSC cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.87 -0.31 1.05e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC cis rs41271473 1.000 rs6701241 chr1:228868477 C/G cg10167378 chr1:228756711 NA 0.53 6.37 0.33 6.16e-10 Chronic lymphocytic leukemia; LUSC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg17143192 chr8:8559678 CLDN23 0.61 9.17 0.45 5.05e-18 Obesity-related traits; LUSC cis rs5009270 0.553 rs2188548 chr7:112235267 C/T cg23628563 chr7:112262597 NA 0.43 5.92 0.31 8.16e-9 Osteoarthritis (hip); LUSC cis rs738322 1.000 rs4379 chr22:38569171 T/C cg25457927 chr22:38595422 NA -0.42 -8.93 -0.44 2.89e-17 Cutaneous nevi; LUSC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg23719950 chr11:63933701 MACROD1 0.59 7.82 0.39 6.89e-14 Mean platelet volume; LUSC cis rs9807841 0.592 rs7250071 chr19:10765819 A/G cg09936142 chr19:10668400 KRI1 0.4 6.35 0.33 7.15e-10 Inflammatory skin disease; LUSC cis rs7789940 0.904 rs61294900 chr7:75937212 A/T cg15798862 chr7:76129360 DTX2 -0.45 -7.15 -0.36 5.43e-12 Multiple sclerosis; LUSC cis rs9653442 0.866 rs11123811 chr2:100760172 T/C cg22139774 chr2:100720529 AFF3 -0.53 -9.53 -0.46 3.37e-19 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg08219700 chr8:58056026 NA 0.45 5.87 0.31 1.07e-8 Developmental language disorder (linguistic errors); LUSC cis rs2729354 1.000 rs2511983 chr11:57346874 A/G cg24343310 chr11:57249947 NA 0.35 6.32 0.33 8.15e-10 Blood protein levels; LUSC cis rs2760061 0.583 rs708110 chr1:228190805 T/A cg04850211 chr1:228464232 OBSCN -0.35 -5.89 -0.31 9.62e-9 Diastolic blood pressure; LUSC cis rs4980532 1 rs4980532 chr11:63680719 C/T cg27373749 chr11:63775612 MACROD1 0.35 6.0 0.31 5.27e-9 Pulse pressure; LUSC trans rs2980439 0.607 rs2980419 chr8:8114141 A/T cg21775007 chr8:11205619 TDH 0.5 6.93 0.35 2.18e-11 Neuroticism; LUSC cis rs7089973 0.604 rs11196952 chr10:116607592 G/A cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9325144 0.505 rs901635 chr12:38646572 A/C cg13010199 chr12:38710504 ALG10B -0.6 -9.19 -0.45 4.27e-18 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.31 0.74 2.75e-60 Homoarginine levels; LUSC trans rs11098499 0.754 rs938056 chr4:120237453 C/T cg25214090 chr10:38739885 LOC399744 0.44 6.62 0.34 1.46e-10 Corneal astigmatism; LUSC cis rs2404602 0.662 rs908817 chr15:76639191 G/A cg23625390 chr15:77176239 SCAPER -0.61 -9.37 -0.46 1.14e-18 Blood metabolite levels; LUSC cis rs9747201 0.889 rs4789784 chr17:80179213 G/A cg18209359 chr17:80159595 CCDC57 -0.36 -5.82 -0.3 1.39e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs981844 0.961 rs56148270 chr4:154660874 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg26314531 chr2:26401878 FAM59B -0.7 -9.6 -0.47 1.92e-19 Gut microbiome composition (summer); LUSC cis rs763121 0.853 rs9622833 chr22:39000397 G/A cg14440974 chr22:39074834 NA -0.36 -6.03 -0.31 4.42e-9 Menopause (age at onset); LUSC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.53 -5.75 -0.3 2.05e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9837602 1.000 rs71313585 chr3:99770696 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.92 -0.31 7.91e-9 Breast cancer; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg01802117 chr1:53393560 SCP2 0.46 7.51 0.38 5.37e-13 Monocyte count; LUSC trans rs8072100 0.840 rs56952963 chr17:45493826 T/C cg04995722 chr7:26192034 NFE2L3 -0.39 -6.31 -0.33 8.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg17971929 chr21:40555470 PSMG1 -0.49 -7.33 -0.37 1.78e-12 Menarche (age at onset); LUSC cis rs2797685 0.898 rs3753503 chr1:7841971 G/A cg04725166 chr1:7887271 PER3 -0.49 -6.37 -0.33 6.43e-10 Crohn's disease; LUSC cis rs9517320 0.515 rs9556969 chr13:99195948 T/C cg07423050 chr13:99094983 FARP1 -0.53 -9.67 -0.47 1.13e-19 Longevity; LUSC cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC cis rs6961069 0.550 rs62461690 chr7:80245792 C/A cg04458919 chr7:80252533 CD36 -0.41 -7.04 -0.36 1.09e-11 Platelet count; LUSC trans rs11098499 0.909 rs78332141 chr4:120375782 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.48 0.33 3.25e-10 Corneal astigmatism; LUSC cis rs8114671 0.836 rs17404569 chr20:33674077 A/C cg24642439 chr20:33292090 TP53INP2 -0.41 -5.89 -0.31 9.23e-9 Height; LUSC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg18477163 chr1:228402036 OBSCN 0.59 10.96 0.51 4.23e-24 Diastolic blood pressure; LUSC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg10700019 chr8:145984882 NA 0.3 5.67 0.3 3.1e-8 Age at first birth; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg08524221 chr17:74732291 SFRS2;MFSD11 0.4 6.75 0.35 6.66e-11 Triglycerides; LUSC cis rs11122272 0.667 rs2244992 chr1:231537220 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.02 0.48 8.05e-21 Hemoglobin concentration; LUSC cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg08085267 chr17:45401833 C17orf57 -0.43 -6.29 -0.33 9.92e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg26380479 chr7:97908229 NA 0.29 6.53 0.34 2.48e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.48 6.95 0.36 1.88e-11 Schizophrenia; LUSC trans rs7726839 0.540 rs56325086 chr5:640728 G/A cg25482853 chr8:67687455 SGK3 1.12 15.55 0.65 2.19e-41 Obesity-related traits; LUSC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg00701064 chr4:6280414 WFS1 0.59 14.09 0.61 1.05e-35 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12908161 1.000 rs12912388 chr15:85344550 T/A cg17507749 chr15:85114479 UBE2QP1 0.53 6.54 0.34 2.25e-10 Schizophrenia; LUSC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg05855489 chr10:104503620 C10orf26 0.59 9.49 0.46 4.66e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg06641503 chr3:48959341 ARIH2 -0.39 -5.98 -0.31 5.63e-9 Parkinson's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04125300 chr20:3388262 C20orf194 -0.51 -6.24 -0.32 1.34e-9 Bipolar disorder and schizophrenia; LUSC cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg24642439 chr20:33292090 TP53INP2 0.55 8.19 0.41 5.74e-15 Height; LUSC cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg22782873 chr19:19639568 YJEFN3 -0.48 -6.11 -0.32 2.7e-9 Bipolar disorder; LUSC cis rs8078723 1.000 rs4795418 chr17:38164851 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.94 -0.36 1.99e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs4332037 0.901 rs7791299 chr7:1935598 T/C cg10840412 chr1:235813424 GNG4 0.61 8.54 0.42 4.74e-16 Bipolar disorder; LUSC cis rs9311676 0.656 rs56232415 chr3:58394850 C/T cg13750441 chr3:58318267 PXK 0.35 6.76 0.35 6.01e-11 Systemic lupus erythematosus; LUSC cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg11244672 chr19:19639970 YJEFN3 -0.57 -6.94 -0.36 2.02e-11 Bipolar disorder; LUSC cis rs9894429 0.608 rs8477 chr17:79618059 C/T cg21984481 chr17:79567631 NPLOC4 -0.55 -10.05 -0.48 6.13e-21 Eye color traits; LUSC cis rs6430585 0.583 rs79633114 chr2:136586825 C/T cg07169764 chr2:136633963 MCM6 1.2 18.44 0.71 7.27e-53 Corneal structure; LUSC cis rs3820068 0.705 rs4646103 chr1:15819827 T/A cg17385448 chr1:15911702 AGMAT 0.39 5.93 0.31 7.69e-9 Systolic blood pressure; LUSC cis rs9581857 0.685 rs9319372 chr13:28042796 C/T cg22138327 chr13:27999177 GTF3A -0.74 -8.26 -0.41 3.34e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs7903847 0.620 rs7923385 chr10:99117097 T/A cg08345082 chr10:99160200 RRP12 -0.36 -7.25 -0.37 2.99e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7193541 0.929 rs12933037 chr16:74660174 G/A cg01733217 chr16:74700730 RFWD3 0.85 15.15 0.64 7.84e-40 Multiple myeloma; LUSC cis rs11195062 0.766 rs1891375 chr10:112001009 A/G cg00817464 chr10:111662876 XPNPEP1 -0.4 -6.04 -0.31 4.07e-9 Multiple myeloma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05045294 chr13:111214096 RAB20 -0.39 -6.25 -0.32 1.27e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs950169 0.922 rs11631096 chr15:85100929 G/C cg17173187 chr15:85201210 NMB 0.37 6.51 0.34 2.74e-10 Schizophrenia; LUSC cis rs6456156 0.586 rs13208636 chr6:167461965 T/G cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg24642439 chr20:33292090 TP53INP2 0.49 7.42 0.38 9.78e-13 Glomerular filtration rate (creatinine); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13837552 chr12:112819996 NA -0.49 -6.28 -0.32 1.04e-9 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.863 rs3736115 chr4:120488703 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.46 -6.26 -0.32 1.2e-9 Corneal astigmatism; LUSC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs997295 0.684 rs4776970 chr15:68080886 A/T cg08079166 chr15:68083412 MAP2K5 0.32 6.28 0.32 1.08e-9 Motion sickness; LUSC cis rs1832871 0.672 rs7750011 chr6:158746802 A/C cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.66 0.47 1.21e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12908161 0.960 rs62019463 chr15:85288087 G/A cg17507749 chr15:85114479 UBE2QP1 0.53 6.56 0.34 2.09e-10 Schizophrenia; LUSC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg00409905 chr10:38381863 ZNF37A -0.38 -6.49 -0.33 3.13e-10 Extrinsic epigenetic age acceleration; LUSC cis rs10791097 0.694 rs1050071 chr11:130747231 C/G cg12179176 chr11:130786555 SNX19 0.8 13.15 0.58 4.19e-32 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg04518342 chr5:131593106 PDLIM4 -0.39 -7.16 -0.36 5.29e-12 Breast cancer; LUSC cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg15103426 chr22:29168792 CCDC117 0.46 6.06 0.31 3.69e-9 Lymphocyte counts; LUSC cis rs11676348 0.729 rs13013361 chr2:218947515 A/T cg06547715 chr2:218990976 CXCR2 0.36 7.3 0.37 2.19e-12 Ulcerative colitis; LUSC trans rs656319 0.513 rs1484641 chr8:9986524 A/C cg21775007 chr8:11205619 TDH 0.48 6.52 0.34 2.58e-10 Myopia (pathological); LUSC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.82 0.35 4.36e-11 Platelet count; LUSC cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg26384229 chr12:38710491 ALG10B -0.81 -13.82 -0.6 1.12e-34 Drug-induced liver injury (flucloxacillin); LUSC cis rs3008870 0.959 rs3008852 chr1:67383416 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.22 0.64 4.2e-40 Lymphocyte percentage of white cells; LUSC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg05535760 chr7:792225 HEATR2 0.74 7.33 0.37 1.7e-12 Cerebrospinal P-tau181p levels; LUSC cis rs2721195 0.967 rs11777703 chr8:145703508 G/A cg17328964 chr8:145687451 CYHR1 0.65 10.75 0.51 2.33e-23 Age at first birth; LUSC cis rs7582180 0.629 rs11693471 chr2:100948062 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.55 -0.42 4.59e-16 Intelligence (multi-trait analysis); LUSC cis rs72949976 0.864 rs62186566 chr2:214024421 G/A cg08319019 chr2:214017104 IKZF2 -0.65 -10.28 -0.49 1.06e-21 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg10295955 chr4:187884368 NA 0.96 19.94 0.74 7.67e-59 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg26441486 chr22:50317300 CRELD2 0.47 7.14 0.36 5.88e-12 Schizophrenia; LUSC trans rs72674100 1.000 rs17026382 chr4:97995366 A/G cg09670535 chr1:18959427 PAX7 -0.61 -6.66 -0.34 1.15e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.83 0.3 1.31e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg18306943 chr3:40428807 ENTPD3 0.38 5.86 0.31 1.13e-8 Renal cell carcinoma; LUSC trans rs804280 1.000 rs804281 chr8:11611865 A/G cg06636001 chr8:8085503 FLJ10661 0.62 9.01 0.44 1.61e-17 Myopia (pathological); LUSC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg24011408 chr12:48396354 COL2A1 0.41 6.03 0.31 4.35e-9 Glycated hemoglobin levels; LUSC cis rs9323205 0.634 rs61987266 chr14:51734909 C/T cg23942311 chr14:51606299 NA -0.4 -7.55 -0.38 4.22e-13 Cancer; LUSC cis rs240764 0.631 rs6932158 chr6:101246010 T/C cg09795085 chr6:101329169 ASCC3 -0.46 -6.63 -0.34 1.33e-10 Neuroticism; LUSC trans rs7980799 0.935 rs2389194 chr12:33529164 A/G cg26384229 chr12:38710491 ALG10B -0.42 -6.01 -0.31 4.83e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg22800045 chr5:56110881 MAP3K1 0.77 10.0 0.48 9.42e-21 Initial pursuit acceleration; LUSC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21659725 chr3:3221576 CRBN 0.88 17.86 0.7 1.47e-50 Intelligence (multi-trait analysis); LUSC cis rs7216064 1.000 rs7223930 chr17:65842186 G/A cg12091567 chr17:66097778 LOC651250 -0.73 -9.42 -0.46 7.94e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6696846 0.791 rs10158848 chr1:205061192 C/T cg21643547 chr1:205240462 TMCC2 -0.43 -7.71 -0.39 1.47e-13 Red blood cell count; LUSC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg21984481 chr17:79567631 NPLOC4 -0.59 -11.22 -0.52 5.11e-25 Eye color traits; LUSC cis rs6121246 0.909 rs6058450 chr20:30343911 G/A cg18721089 chr20:30220636 NA -0.35 -5.97 -0.31 6.21e-9 Mean corpuscular hemoglobin; LUSC trans rs2739330 0.828 rs2330635 chr22:24251344 T/C cg06437703 chr8:37914619 EIF4EBP1 -0.56 -8.66 -0.43 2.05e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg17385448 chr1:15911702 AGMAT 0.37 6.15 0.32 2.19e-9 Systolic blood pressure; LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg15147215 chr3:52552868 STAB1 -0.29 -5.65 -0.3 3.39e-8 Electroencephalogram traits; LUSC cis rs4319547 0.698 rs10773178 chr12:122944752 T/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.86 -0.44 4.89e-17 Body mass index; LUSC cis rs1008375 0.931 rs7435102 chr4:17571480 C/G cg16339924 chr4:17578868 LAP3 0.61 9.29 0.45 2.07e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4332037 0.901 rs11767040 chr7:1945468 C/T cg25206134 chr2:45395956 NA 0.57 6.54 0.34 2.36e-10 Bipolar disorder; LUSC trans rs1864729 1.000 rs2853318 chr8:98283509 A/T cg08679828 chr8:102218111 ZNF706 -0.85 -7.71 -0.39 1.45e-13 Estradiol plasma levels (breast cancer); LUSC trans rs7615952 0.534 rs1503072 chr3:125754691 C/T cg07211511 chr3:129823064 LOC729375 -0.77 -9.85 -0.47 2.89e-20 Blood pressure (smoking interaction); LUSC cis rs4689388 0.890 rs4689397 chr4:6299387 G/A cg25554036 chr4:6271136 WFS1 0.63 12.98 0.58 1.72e-31 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1865760 0.786 rs1436308 chr6:25939567 T/G cg16482183 chr6:26056742 HIST1H1C 0.46 6.62 0.34 1.43e-10 Height; LUSC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg22857025 chr5:266934 NA -1.14 -16.44 -0.67 6.7e-45 Breast cancer; LUSC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg22467129 chr15:76604101 ETFA -0.44 -6.99 -0.36 1.54e-11 Blood metabolite levels; LUSC cis rs926938 0.527 rs360685 chr1:115499795 G/C cg12756093 chr1:115239321 AMPD1 0.45 6.87 0.35 3.2e-11 Autism; LUSC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.66e-10 Lung cancer; LUSC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg00166722 chr3:10149974 C3orf24 0.39 5.84 0.3 1.24e-8 Alzheimer's disease; LUSC cis rs7560272 0.538 rs7599453 chr2:73937901 T/G cg20560298 chr2:73613845 ALMS1 0.41 6.16 0.32 2.14e-9 Schizophrenia; LUSC cis rs9400467 0.528 rs458486 chr6:111696852 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs11051970 0.918 rs73084099 chr12:32539751 C/T cg02745156 chr12:32552066 NA 0.44 6.92 0.35 2.36e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.31e-15 Tonsillectomy; LUSC cis rs4478858 0.698 rs11802155 chr1:31805012 T/C cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs10876993 0.855 rs10877007 chr12:58100058 T/A cg15848620 chr12:58087721 OS9 -0.56 -7.94 -0.4 3.07e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs506338 0.517 rs1207179 chr11:64450795 C/T cg19395706 chr11:64412079 NRXN2 0.28 5.75 0.3 1.99e-8 Body mass index;Urate levels; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg13397359 chr6:42928475 GNMT 0.58 9.85 0.47 2.9e-20 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg10360139 chr7:1886902 MAD1L1 -0.38 -5.66 -0.3 3.18e-8 Bipolar disorder and schizophrenia; LUSC cis rs834811 1.000 rs834811 chr7:135884571 A/G cg01726295 chr7:135938950 NA 0.37 6.43 0.33 4.38e-10 Post-traumatic stress disorder; LUSC cis rs10992471 0.631 rs2296667 chr9:95274338 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.48 -0.33 3.27e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg12516959 chr21:47718080 NA 0.39 6.39 0.33 5.56e-10 Testicular germ cell tumor; LUSC cis rs694739 0.654 rs10897488 chr11:64140806 T/C cg23796481 chr11:64053134 BAD;GPR137 0.53 8.16 0.41 7e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs3540 0.597 rs7498113 chr15:91051192 C/G cg03599575 chr15:90893182 GABARAPL3 -0.33 -5.66 -0.3 3.3e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs3540 0.554 rs12443252 chr15:91064690 C/T cg22089800 chr15:90895588 ZNF774 -0.65 -9.76 -0.47 5.71e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs11690935 0.959 rs7597387 chr2:172577116 T/C cg13550731 chr2:172543902 DYNC1I2 -0.89 -15.03 -0.64 2.32e-39 Schizophrenia; LUSC cis rs9300255 0.602 rs2682434 chr12:123694724 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg03929089 chr4:120376271 NA -1.04 -20.32 -0.74 2.46e-60 Height; LUSC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg20476274 chr7:133979776 SLC35B4 0.85 16.0 0.66 3.61e-43 Mean platelet volume; LUSC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg00031303 chr3:195681400 NA 0.68 9.68 0.47 1.11e-19 Pancreatic cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12550816 chr19:47163979 DACT3 -0.45 -5.99 -0.31 5.34e-9 Bipolar disorder and schizophrenia; LUSC cis rs9513627 1.000 rs3928271 chr13:100186958 G/A cg25919922 chr13:100150906 NA 0.78 6.56 0.34 2.11e-10 Obesity-related traits; LUSC cis rs9614461 0.702 rs16993867 chr22:45733199 A/G cg13318129 chr22:45737514 FAM118A 0.74 9.07 0.44 1.04e-17 Tonsillectomy; LUSC cis rs79387448 0.638 rs78123896 chr2:103075417 T/C cg09003973 chr2:102972529 NA 0.97 9.74 0.47 6.57e-20 Gut microbiota (bacterial taxa); LUSC cis rs453301 0.631 rs17700611 chr8:8793654 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.42 -0.38 1.01e-12 Joint mobility (Beighton score); LUSC cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs3772130 0.962 rs11719093 chr3:121487686 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.7 10.05 0.48 6.12e-21 Cognitive performance; LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg22920501 chr2:26401640 FAM59B -0.78 -11.56 -0.53 3.28e-26 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.64 0.54 1.65e-26 Prudent dietary pattern; LUSC cis rs3820068 0.581 rs68052904 chr1:15916714 T/C cg24675056 chr1:15929824 NA 0.46 7.84 0.39 6.02e-14 Systolic blood pressure; LUSC cis rs11098499 0.691 rs9307471 chr4:120261262 G/A cg09307838 chr4:120376055 NA 0.64 9.79 0.47 4.53e-20 Corneal astigmatism; LUSC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg17633681 chr16:88106987 BANP 0.52 9.88 0.48 2.27e-20 Menopause (age at onset); LUSC cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.71 -9.33 -0.45 1.48e-18 Chronic sinus infection; LUSC cis rs7169223 0.653 rs12905740 chr15:79082364 C/T cg21242079 chr15:79101063 ADAMTS7 -0.42 -6.21 -0.32 1.57e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg26695010 chr11:65641043 EFEMP2 -0.47 -7.1 -0.36 7.54e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs11048434 0.761 rs1805721 chr12:9147569 A/G cg23795048 chr12:9217529 LOC144571 -0.33 -5.82 -0.3 1.4e-8 Sjögren's syndrome; LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.81 11.59 0.54 2.51e-26 Alzheimer's disease; LUSC cis rs4132509 0.744 rs58594024 chr1:243862702 C/A cg21452805 chr1:244014465 NA 0.6 6.59 0.34 1.7e-10 RR interval (heart rate); LUSC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg22968622 chr17:43663579 NA -0.78 -12.12 -0.55 2.81e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs4698048 0.510 rs12509714 chr4:10107091 C/G cg26043149 chr18:55253948 FECH 0.42 6.68 0.34 9.94e-11 Skin aging (microtopography measurement); LUSC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg21984481 chr17:79567631 NPLOC4 0.73 15.54 0.65 2.39e-41 Eye color traits; LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 15.14 0.64 8.98e-40 Platelet count; LUSC cis rs6977660 0.660 rs13225400 chr7:19817016 A/G cg07541023 chr7:19748670 TWISTNB 0.61 6.57 0.34 1.91e-10 Thyroid stimulating hormone; LUSC cis rs977987 0.931 rs8057084 chr16:75492706 G/T cg03315344 chr16:75512273 CHST6 -0.52 -9.86 -0.47 2.65e-20 Dupuytren's disease; LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.66 0.63 6.18e-38 Platelet count; LUSC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg05347473 chr6:146136440 FBXO30 0.56 9.47 0.46 5.19e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg13395646 chr4:1353034 KIAA1530 -0.63 -9.8 -0.47 4.25e-20 Longevity; LUSC cis rs897984 0.571 rs7184567 chr16:31021078 C/T cg02466173 chr16:30829666 NA -0.53 -10.24 -0.49 1.36e-21 Dementia with Lewy bodies; LUSC cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.29e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs17685 0.753 rs10476 chr7:75696420 C/T cg19862616 chr7:65841803 NCRNA00174 -1.12 -19.94 -0.74 7.72e-59 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.42 -6.2 -0.32 1.68e-9 Schizophrenia; LUSC cis rs926938 0.527 rs360584 chr1:115463181 G/A cg12756093 chr1:115239321 AMPD1 0.46 7.0 0.36 1.43e-11 Autism; LUSC cis rs8179 0.645 rs10264916 chr7:92286376 A/G cg15732164 chr7:92237376 CDK6 -0.42 -6.15 -0.32 2.22e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs4629180 0.920 rs4851458 chr2:102108794 T/C cg04415270 chr2:102091202 RFX8 -0.56 -9.14 -0.45 6.37e-18 Chronic rhinosinusitis with nasal polyps; LUSC cis rs847577 0.609 rs6977321 chr7:97774859 A/G cg24562669 chr7:97807699 LMTK2 0.47 8.48 0.42 7.39e-16 Breast cancer; LUSC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.38 -0.33 5.96e-10 High light scatter reticulocyte count; LUSC cis rs4774899 0.872 rs11855648 chr15:57394050 A/G cg21617494 chr15:57618479 NA 0.37 6.19 0.32 1.77e-9 Urinary tract infection frequency; LUSC cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg17063962 chr7:91808500 NA 0.59 9.38 0.46 1.07e-18 Breast cancer; LUSC cis rs870825 0.616 rs4610378 chr4:185624220 C/T cg04058563 chr4:185651563 MLF1IP -0.84 -13.78 -0.6 1.56e-34 Blood protein levels; LUSC cis rs12900413 0.959 rs28430604 chr15:90313782 C/T cg24249390 chr15:90295951 MESP1 -0.44 -6.52 -0.34 2.61e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs17401966 0.597 rs2180185 chr1:10246129 C/G cg19773385 chr1:10388646 KIF1B -0.4 -7.1 -0.36 7.54e-12 Hepatocellular carcinoma; LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg00106254 chr7:1943704 MAD1L1 -0.41 -5.97 -0.31 6.05e-9 Schizophrenia; LUSC cis rs738321 0.762 rs4820321 chr22:38579569 T/A cg25457927 chr22:38595422 NA -0.42 -8.04 -0.4 1.54e-14 Breast cancer; LUSC cis rs11645898 0.935 rs28419077 chr16:72196776 A/G cg14768367 chr16:72042858 DHODH -0.61 -6.74 -0.35 7.01e-11 Blood protein levels; LUSC cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.14e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 9.77 0.47 5.27e-20 Eosinophil percentage of white cells; LUSC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg06028605 chr16:24865363 SLC5A11 -0.7 -11.16 -0.52 8.77e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs10140922 0.966 rs10132397 chr14:35822447 G/T cg07166546 chr14:35805898 NA -0.24 -5.96 -0.31 6.55e-9 Hip circumference adjusted for BMI; LUSC cis rs9549260 0.755 rs9532579 chr13:41243458 T/C cg21288729 chr13:41239152 FOXO1 0.63 9.84 0.47 3.22e-20 Red blood cell count; LUSC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg23601095 chr6:26197514 HIST1H3D -0.68 -6.99 -0.36 1.53e-11 Gout;Renal underexcretion gout; LUSC cis rs6599077 0.951 rs9860449 chr3:40094033 T/A cg13683864 chr3:40499215 RPL14 -0.57 -7.31 -0.37 2.02e-12 Sleep-related phenotypes; LUSC cis rs10489202 0.632 rs6659713 chr1:168072249 G/T cg24449463 chr1:168025552 DCAF6 0.62 9.48 0.46 4.92e-19 Schizophrenia; LUSC cis rs210142 1.000 rs210142 chr6:33546837 T/C cg24505687 chr6:33548425 BAK1 0.45 6.51 0.34 2.78e-10 Platelet count;Plateletcrit;Chronic lymphocytic leukemia; LUSC cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg05707623 chr12:122985044 ZCCHC8 -0.66 -8.47 -0.42 7.9e-16 Body mass index; LUSC cis rs1729951 0.575 rs747842 chr3:136703121 A/C cg21827317 chr3:136751795 NA 0.4 7.21 0.37 3.8e-12 Neuroticism; LUSC cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg24130564 chr14:104152367 KLC1 0.44 6.42 0.33 4.68e-10 Intelligence (multi-trait analysis); LUSC cis rs10465746 0.747 rs1952066 chr1:84436456 T/C cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.02e-9 Obesity-related traits; LUSC cis rs134594 1.000 rs20037 chr22:29477841 T/G cg03665785 chr22:29458676 C22orf31 0.28 5.69 0.3 2.78e-8 Birth weight; LUSC cis rs745570 0.833 rs1696757 chr17:77800743 C/T cg04986373 chr17:77768687 CBX8 -0.33 -6.49 -0.33 3.17e-10 Breast cancer; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg26304593 chr6:42947056 PEX6 -0.52 -8.2 -0.41 5.06e-15 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs11039798 0.588 rs10838970 chr11:48606267 G/T cg15704280 chr7:45808275 SEPT13 0.65 7.19 0.37 4.24e-12 Axial length; LUSC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg05623727 chr3:50126028 RBM5 0.33 6.11 0.32 2.77e-9 Intelligence (multi-trait analysis); LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg06877462 chr1:205807181 PM20D1 0.49 8.82 0.43 6.26e-17 Menarche (age at onset); LUSC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg11764359 chr7:65958608 NA 0.69 10.65 0.5 5.38e-23 Aortic root size; LUSC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.58 0.34 1.86e-10 Lung cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05031797 chr17:60557085 TLK2 -0.47 -6.24 -0.32 1.32e-9 Hepatitis; LUSC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -7.77 -0.39 9.7e-14 Developmental language disorder (linguistic errors); LUSC cis rs73206853 0.841 rs56184938 chr12:110817193 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.07 0.36 9.13e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.14 0.32 2.33e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs806215 1.000 rs712701 chr7:127251188 T/G cg25922125 chr7:127225783 GCC1 0.58 7.2 0.37 4.04e-12 Type 2 diabetes; LUSC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg05855489 chr10:104503620 C10orf26 0.59 9.44 0.46 6.79e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg20887711 chr4:1340912 KIAA1530 0.56 8.64 0.43 2.31e-16 Longevity; LUSC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg19346786 chr7:2764209 NA -0.44 -6.97 -0.36 1.68e-11 Height; LUSC cis rs3754214 0.823 rs10888579 chr1:150261925 C/T cg15654264 chr1:150340011 RPRD2 -0.45 -7.29 -0.37 2.25e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs6901250 0.610 rs9400964 chr6:117144808 G/T cg12892004 chr6:117198278 RFX6 0.4 7.68 0.39 1.81e-13 C-reactive protein levels; LUSC trans rs72674100 1.000 rs7672690 chr4:97954777 A/G cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs17270561 0.609 rs9393658 chr6:25730438 C/T cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7180079 1.000 rs7183694 chr15:64538955 G/C cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg08736216 chr1:53307985 ZYG11A -0.28 -5.82 -0.3 1.38e-8 Monocyte count; LUSC cis rs7223966 1.000 rs72848797 chr17:61934664 G/A cg05941027 chr17:61774174 LIMD2 0.22 5.71 0.3 2.5e-8 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs2228479 0.850 rs11076619 chr16:89831243 C/A cg24644049 chr4:85504048 CDS1 0.88 7.53 0.38 4.81e-13 Skin colour saturation; LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.84 -0.57 5.88e-31 Platelet count; LUSC cis rs8072100 0.544 rs7214993 chr17:45386797 C/G cg08085267 chr17:45401833 C17orf57 -0.42 -6.25 -0.32 1.25e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12291225 0.679 rs1043237 chr11:14289053 A/T cg05501817 chr11:14380813 RRAS2 -0.6 -9.17 -0.45 5.03e-18 Sense of smell; LUSC cis rs4242434 0.819 rs1871902 chr8:22470710 G/A cg03733263 chr8:22462867 KIAA1967 0.83 14.01 0.61 2.07e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs7917772 0.628 rs4604806 chr10:104373904 G/A cg22532475 chr10:104410764 TRIM8 -0.25 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs9329221 0.905 rs17765901 chr8:10249480 G/T cg08975724 chr8:8085496 FLJ10661 -0.48 -6.95 -0.36 1.97e-11 Neuroticism; LUSC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg06558623 chr16:89946397 TCF25 1.11 9.73 0.47 7.07e-20 Skin colour saturation; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg22638593 chr5:131593259 PDLIM4 0.4 6.37 0.33 6.11e-10 Blood metabolite levels; LUSC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg02187348 chr16:89574699 SPG7 -0.49 -7.68 -0.39 1.77e-13 Multiple myeloma (IgH translocation); LUSC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg18876405 chr7:65276391 NA 0.54 8.35 0.42 1.84e-15 Aortic root size; LUSC cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg02175503 chr12:58329896 NA 0.61 9.99 0.48 9.8e-21 Intelligence (multi-trait analysis); LUSC cis rs16937 0.662 rs11240376 chr1:205146460 A/G cg00857998 chr1:205179979 DSTYK 0.46 6.45 0.33 3.99e-10 Schizophrenia; LUSC cis rs539096 0.540 rs3011217 chr1:44303266 C/T cg13246856 chr1:44399776 ARTN -0.27 -6.0 -0.31 5.11e-9 Intelligence (multi-trait analysis); LUSC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg00339695 chr16:24857497 SLC5A11 0.62 9.02 0.44 1.52e-17 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.909 rs1809406 chr4:120377122 G/A cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.54e-25 Corneal astigmatism; LUSC cis rs950027 0.620 rs1049518 chr15:45653367 G/A cg26924012 chr15:45694286 SPATA5L1 0.79 12.5 0.56 1.13e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg26335602 chr6:28129616 ZNF389 -0.42 -5.73 -0.3 2.25e-8 Depression; LUSC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg06637938 chr14:75390232 RPS6KL1 0.52 8.41 0.42 1.21e-15 Height; LUSC cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg03517284 chr6:25882590 NA 0.64 11.21 0.52 5.66e-25 Blood metabolite levels; LUSC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg12011299 chr4:100065546 ADH4 0.64 10.2 0.49 1.98e-21 Alcohol dependence; LUSC cis rs5758511 0.508 rs28715885 chr22:42441091 T/G cg00645731 chr22:42541494 CYP2D7P1 0.51 8.04 0.4 1.53e-14 Birth weight; LUSC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.13 -0.32 2.42e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg22868518 chr11:507468 RNH1 -0.65 -6.12 -0.32 2.61e-9 Body mass index; LUSC cis rs73200209 0.744 rs3741768 chr12:116446445 C/T cg01776926 chr12:116560359 MED13L -0.51 -6.0 -0.31 5.27e-9 Total body bone mineral density; LUSC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg03433033 chr1:76189801 ACADM 0.73 9.54 0.46 3.12e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.17 -0.32 1.94e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3768617 0.811 rs10911232 chr1:183052533 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 9.41 0.46 8.24e-19 Fuchs's corneal dystrophy; LUSC cis rs9581857 0.685 rs78595793 chr13:28031881 C/T cg22138327 chr13:27999177 GTF3A 0.79 8.22 0.41 4.57e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg17971929 chr21:40555470 PSMG1 0.79 13.73 0.6 2.61e-34 Cognitive function; LUSC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg04111992 chr7:158790115 NA -0.37 -5.84 -0.3 1.21e-8 Facial morphology (factor 20); LUSC trans rs12310956 0.532 rs11052922 chr12:33957476 A/G cg26384229 chr12:38710491 ALG10B 0.67 10.54 0.5 1.33e-22 Morning vs. evening chronotype; LUSC cis rs4363385 0.510 rs11588463 chr1:152901984 T/C cg00922841 chr1:152955080 SPRR1A -0.39 -6.41 -0.33 4.9e-10 Inflammatory skin disease; LUSC cis rs12575480 0.637 rs6578976 chr11:2095968 T/C cg15541987 chr11:2077307 NA -0.41 -6.13 -0.32 2.48e-9 Pursuit maintenance gain; LUSC cis rs2455601 1.000 rs12223690 chr11:8901824 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.56 -0.34 2e-10 Schizophrenia; LUSC cis rs225245 0.817 rs225297 chr17:33924587 G/A cg05299278 chr17:33885742 SLFN14 0.31 6.9 0.35 2.68e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg03264133 chr6:25882463 NA -0.34 -5.66 -0.3 3.22e-8 Height; LUSC cis rs9818758 0.607 rs11706052 chr3:49064110 A/G cg00383909 chr3:49044727 WDR6 1.36 11.7 0.54 1.01e-26 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs9309473 0.606 rs62149804 chr2:73837006 T/A cg20560298 chr2:73613845 ALMS1 -0.54 -6.34 -0.33 7.34e-10 Metabolite levels; LUSC cis rs9649213 0.519 rs3735258 chr7:97866291 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.69 -9.64 -0.47 1.46e-19 Prostate cancer (SNP x SNP interaction); LUSC cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg06212747 chr3:49208901 KLHDC8B 0.46 5.86 0.31 1.09e-8 Menarche (age at onset); LUSC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg08859206 chr1:53392774 SCP2 -0.55 -9.66 -0.47 1.26e-19 Monocyte count; LUSC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg06618935 chr21:46677482 NA -0.37 -7.44 -0.38 8.78e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1577917 0.771 rs7742201 chr6:86432930 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.52 -8.13 -0.41 8.43e-15 Response to antipsychotic treatment; LUSC trans rs853679 0.517 rs1904840 chr6:28108232 C/T cg06606381 chr12:133084897 FBRSL1 -0.45 -5.95 -0.31 6.74e-9 Depression; LUSC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg16434002 chr17:42200994 HDAC5 -0.45 -6.19 -0.32 1.75e-9 Total body bone mineral density; LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg23978390 chr7:1156363 C7orf50 0.52 7.23 0.37 3.36e-12 Longevity;Endometriosis; LUSC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs1559088 1.000 rs1974783 chr19:33551507 C/G cg27124370 chr19:33622961 WDR88 0.52 6.71 0.34 8.59e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.38 0.64 1.02e-40 Platelet count; LUSC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg13798780 chr7:105162888 PUS7 0.6 6.46 0.33 3.61e-10 Bipolar disorder (body mass index interaction); LUSC cis rs3806843 0.966 rs7710380 chr5:140156264 T/C cg19875535 chr5:140030758 IK 0.49 8.09 0.4 1.13e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs9640161 0.711 rs3735170 chr7:150034184 T/C cg21361702 chr7:150065534 REPIN1 0.5 6.51 0.34 2.8e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.6 10.06 0.48 5.68e-21 Lymphocyte counts; LUSC cis rs34421088 0.506 rs4841518 chr8:11145963 G/C cg21775007 chr8:11205619 TDH 0.49 7.0 0.36 1.43e-11 Neuroticism; LUSC cis rs7940866 0.903 rs1820353 chr11:130870765 A/G cg12179176 chr11:130786555 SNX19 0.61 9.41 0.46 8.49e-19 Schizophrenia; LUSC cis rs3820068 0.603 rs59475085 chr1:15911131 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.95 0.31 6.81e-9 Systolic blood pressure; LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 4.92e-10 Systemic lupus erythematosus; LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg05368731 chr17:41323189 NBR1 0.93 16.11 0.66 1.32e-43 Menopause (age at onset); LUSC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.36 -7.56 -0.38 3.85e-13 Schizophrenia; LUSC cis rs7659604 0.728 rs6852923 chr4:122688324 G/A cg05802129 chr4:122689817 NA -0.48 -8.29 -0.41 2.76e-15 Type 2 diabetes; LUSC cis rs9549367 0.713 rs9549357 chr13:113860121 C/T cg00898013 chr13:113819073 PROZ -0.57 -8.28 -0.41 3.05e-15 Platelet distribution width; LUSC cis rs7584330 0.518 rs7561919 chr2:238435241 A/G cg14458575 chr2:238380390 NA 0.58 7.16 0.36 5.03e-12 Prostate cancer; LUSC cis rs3018712 0.532 rs2513294 chr11:68421194 C/T cg22747802 chr11:68417633 NA -0.43 -6.13 -0.32 2.51e-9 Total body bone mineral density; LUSC cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.99 -0.31 5.3e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11072805 1 rs11072805 chr15:79078518 T/C cg00540400 chr15:79124168 NA -0.4 -6.99 -0.36 1.46e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.91 15.83 0.65 1.68e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg19920283 chr7:105172520 RINT1 0.54 5.72 0.3 2.39e-8 Bipolar disorder (body mass index interaction); LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg09436375 chr6:42928200 GNMT -0.3 -6.88 -0.35 3.04e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08020660 chr16:30076480 ALDOA -0.4 -6.31 -0.33 9.08e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg19318889 chr4:1322082 MAEA 0.47 7.94 0.4 3.12e-14 Obesity-related traits; LUSC cis rs11630290 0.575 rs7169210 chr15:64165069 T/C cg12036633 chr15:63758958 NA 0.5 5.91 0.31 8.67e-9 Iris characteristics; LUSC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg19046167 chr17:80928561 B3GNTL1 -0.45 -6.79 -0.35 5.08e-11 Breast cancer; LUSC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg05802129 chr4:122689817 NA -0.46 -7.79 -0.39 8.59e-14 Type 2 diabetes; LUSC cis rs12368653 0.641 rs7311632 chr12:58086340 A/C cg15848620 chr12:58087721 OS9 -0.41 -5.82 -0.3 1.38e-8 Multiple sclerosis; LUSC cis rs1865721 0.804 rs59187673 chr18:73143964 A/G cg26385618 chr18:73139727 C18orf62 -0.53 -9.69 -0.47 9.64e-20 Intelligence; LUSC cis rs11997175 0.846 rs6999445 chr8:33732693 G/A ch.8.33884649F chr8:33765107 NA 0.56 9.07 0.44 1.01e-17 Body mass index; LUSC cis rs7582720 1.000 rs72928620 chr2:203840973 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs10266483 0.705 rs1111649 chr7:63756813 G/T cg24201672 chr7:64023550 ZNF680 -0.45 -5.75 -0.3 2.05e-8 Response to statin therapy; LUSC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15506890 chr2:3487001 NA -0.58 -9.58 -0.46 2.23e-19 Neurofibrillary tangles; LUSC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg11366901 chr6:160182831 ACAT2 0.9 12.53 0.57 8.66e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs6701037 1.000 rs11580331 chr1:175123288 T/C cg00321850 chr1:175162397 KIAA0040 -0.43 -7.3 -0.37 2.06e-12 Alcohol dependence; LUSC trans rs1459104 0.636 rs559362 chr11:55275456 T/G cg15704280 chr7:45808275 SEPT13 0.62 6.67 0.34 1.09e-10 Body mass index; LUSC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg03060546 chr3:49711283 APEH 0.71 11.95 0.55 1.23e-27 Resting heart rate; LUSC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg24060327 chr5:131705240 SLC22A5 -0.41 -6.69 -0.34 9.51e-11 Blood metabolite levels; LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs11997175 0.510 rs10503953 chr8:33797783 C/T ch.8.33884649F chr8:33765107 NA 0.47 6.92 0.35 2.34e-11 Body mass index; LUSC cis rs4730250 0.707 rs4730222 chr7:106810293 G/C cg02696742 chr7:106810147 HBP1 -0.66 -9.26 -0.45 2.62e-18 Osteoarthritis; LUSC cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg17366294 chr4:99064904 C4orf37 0.59 10.62 0.5 6.67e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7917772 0.582 rs4917973 chr10:104333700 C/T cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs9300255 0.739 rs1533703 chr12:123742093 T/G cg00376283 chr12:123451042 ABCB9 0.66 8.32 0.41 2.27e-15 Neutrophil percentage of white cells; LUSC cis rs4268898 0.931 rs60716082 chr2:24526265 T/A cg06627628 chr2:24431161 ITSN2 -0.62 -9.16 -0.45 5.21e-18 Asthma; LUSC cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg18681998 chr4:17616180 MED28 0.84 15.64 0.65 9.43e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10911232 0.507 rs3934579 chr1:183027432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.15 0.52 9.13e-25 Hypertriglyceridemia; LUSC cis rs453301 0.631 rs28572014 chr8:8793607 C/T cg15556689 chr8:8085844 FLJ10661 -0.61 -9.71 -0.47 8.47e-20 Joint mobility (Beighton score); LUSC cis rs950027 0.620 rs1145076 chr15:45684508 G/T cg21132104 chr15:45694354 SPATA5L1 0.4 5.86 0.31 1.1e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg12923728 chr3:195709715 SDHAP1 -0.78 -12.27 -0.56 8.07e-29 Pancreatic cancer; LUSC cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg18721089 chr20:30220636 NA -0.36 -6.14 -0.32 2.35e-9 Mean corpuscular hemoglobin; LUSC cis rs6696846 0.936 rs6662930 chr1:205041465 T/C cg21545522 chr1:205238299 TMCC2 0.46 8.4 0.42 1.27e-15 Red blood cell count; LUSC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg12463550 chr7:65579703 CRCP 0.5 7.25 0.37 2.97e-12 Aortic root size; LUSC cis rs6121246 0.909 rs1075698 chr20:30387992 G/C cg18721089 chr20:30220636 NA -0.35 -6.05 -0.31 3.82e-9 Mean corpuscular hemoglobin; LUSC cis rs10089 0.903 rs6862701 chr5:127391249 C/T cg19767477 chr5:127420684 SLC12A2 -0.4 -5.74 -0.3 2.12e-8 Ileal carcinoids; LUSC cis rs5769765 0.542 rs1535189 chr22:50249131 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.63 6.79 0.35 5e-11 Schizophrenia; LUSC cis rs7246967 0.611 rs8107724 chr19:22867414 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs13385 0.769 rs17118785 chr5:139653208 A/G cg26211634 chr5:139558579 C5orf32 -0.42 -6.06 -0.31 3.76e-9 Atrial fibrillation; LUSC cis rs548181 0.611 rs609200 chr11:125383808 G/A cg03464685 chr11:125439445 EI24 -1.39 -14.31 -0.62 1.46e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7582720 0.943 rs72936879 chr2:203792628 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg25046584 chr21:32932016 TIAM1 0.5 7.06 0.36 9.52e-12 Cognitive function;Information processing speed; LUSC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg11663144 chr21:46675770 NA -0.43 -7.5 -0.38 5.85e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs16910800 0.731 rs55908012 chr11:23191640 G/A cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs4888262 0.526 rs8056718 chr16:74612030 G/C cg01733217 chr16:74700730 RFWD3 0.75 12.23 0.56 1.14e-28 Testicular germ cell tumor; LUSC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg22467129 chr15:76604101 ETFA -0.43 -6.9 -0.35 2.67e-11 Blood metabolite levels; LUSC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.91 -0.31 8.41e-9 Crohn's disease; LUSC cis rs9473147 0.516 rs7754971 chr6:47590476 C/T cg02130027 chr6:47444894 CD2AP 0.36 5.76 0.3 1.86e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg04586622 chr2:25135609 ADCY3 0.41 8.63 0.43 2.52e-16 Body mass index; LUSC cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7605827 0.930 rs1019359 chr2:15524615 T/C cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs10752881 0.809 rs3768613 chr1:183106296 G/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.51e-22 Colorectal cancer; LUSC cis rs5758659 0.714 rs5751216 chr22:42508937 G/T cg04733989 chr22:42467013 NAGA -0.41 -6.78 -0.35 5.46e-11 Cognitive function; LUSC cis rs1908814 0.516 rs60176945 chr8:11796674 T/C cg00262122 chr8:11665843 FDFT1 0.4 5.9 0.31 8.84e-9 Neuroticism; LUSC trans rs2262909 0.962 rs73019842 chr19:22249909 T/G cg05197062 chr11:11642011 GALNTL4 0.56 7.88 0.4 4.75e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6961069 0.708 rs2065668 chr7:80220608 A/G cg04458919 chr7:80252533 CD36 0.4 7.01 0.36 1.29e-11 Platelet count; LUSC cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg06064525 chr11:970664 AP2A2 -0.48 -10.38 -0.49 4.55e-22 Alzheimer's disease (late onset); LUSC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg12011299 chr4:100065546 ADH4 -0.69 -10.39 -0.49 4.15e-22 Alcohol dependence; LUSC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg20790798 chr5:1857306 NA -0.5 -8.62 -0.43 2.74e-16 Cardiovascular disease risk factors; LUSC cis rs854765 0.693 rs35451946 chr17:17764061 C/G cg04398451 chr17:18023971 MYO15A 0.5 8.03 0.4 1.73e-14 Total body bone mineral density; LUSC cis rs35995292 0.534 rs10274968 chr7:38939254 C/T cg19327137 chr7:38886074 VPS41 0.56 10.52 0.5 1.51e-22 Subjective well-being (multi-trait analysis); LUSC cis rs892961 0.965 rs312856 chr17:75401598 A/G cg05865280 chr17:75406074 SEPT9 0.49 10.49 0.5 1.86e-22 Airflow obstruction; LUSC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg19717773 chr7:2847554 GNA12 -0.34 -5.67 -0.3 3.12e-8 Height; LUSC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg18681998 chr4:17616180 MED28 0.85 15.93 0.66 6.57e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7580658 0.963 rs12622436 chr2:128081682 C/A cg09760422 chr2:128146352 NA -0.32 -7.24 -0.37 3.13e-12 Protein C levels; LUSC cis rs8114671 0.562 rs6119536 chr20:33450041 A/G cg24642439 chr20:33292090 TP53INP2 -0.39 -5.74 -0.3 2.07e-8 Height; LUSC cis rs2439831 0.867 rs12324572 chr15:43636200 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.16 0.58 3.88e-32 Lung cancer in ever smokers; LUSC cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.91 0.31 8.5e-9 Rheumatoid arthritis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06547771 chr11:43380393 TTC17 -0.41 -6.14 -0.32 2.34e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1451375 0.712 rs11974297 chr7:50618260 A/G cg18232548 chr7:50535776 DDC 0.56 8.79 0.43 8.24e-17 Malaria; LUSC cis rs9815354 0.812 rs17283929 chr3:41941898 C/G cg03022575 chr3:42003672 ULK4 -0.82 -8.99 -0.44 1.94e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs7267979 0.873 rs6132822 chr20:25228695 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.68 12.94 0.58 2.53e-31 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1322512 0.917 rs2475783 chr6:153022912 G/A cg27316956 chr6:152958899 SYNE1 0.37 6.19 0.32 1.75e-9 Tonometry; LUSC cis rs9296092 0.538 rs75501442 chr6:33519493 A/G cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.59e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24669129 chr7:155089712 INSIG1 -0.42 -6.19 -0.32 1.74e-9 Electrocardiographic conduction measures; LUSC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg04352962 chr1:209979756 IRF6 0.55 6.3 0.33 9.18e-10 Cleft lip with or without cleft palate; LUSC cis rs8017423 0.967 rs1959002 chr14:90670994 T/A cg14092571 chr14:90743983 NA -0.35 -5.81 -0.3 1.47e-8 Mortality in heart failure; LUSC cis rs2486288 0.656 rs11629807 chr15:45547037 T/C cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.76 -0.51 2.15e-23 Glomerular filtration rate; LUSC cis rs1949733 1.000 rs2631745 chr4:8490530 T/C cg11789530 chr4:8429930 ACOX3 -0.61 -9.62 -0.47 1.63e-19 Response to antineoplastic agents; LUSC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg13683864 chr3:40499215 RPL14 -1.05 -18.15 -0.7 1.07e-51 Renal cell carcinoma; LUSC cis rs372883 0.648 rs382732 chr21:30719010 A/G cg08807101 chr21:30365312 RNF160 0.63 9.72 0.47 7.67e-20 Pancreatic cancer; LUSC cis rs1595825 0.945 rs73058813 chr2:198858268 A/G cg00982548 chr2:198649783 BOLL -0.56 -7.05 -0.36 1.03e-11 Ulcerative colitis; LUSC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg20891558 chr2:74357851 NA 0.85 15.73 0.65 4.07e-42 Gestational age at birth (maternal effect); LUSC cis rs2354432 0.607 rs3766524 chr1:146729093 A/G cg25205988 chr1:146714368 CHD1L -1.02 -9.27 -0.45 2.31e-18 Mitochondrial DNA levels; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg26668828 chr6:292823 DUSP22 -0.51 -7.68 -0.39 1.78e-13 Menopause (age at onset); LUSC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg03806693 chr22:41940476 POLR3H -0.98 -13.99 -0.61 2.6e-35 Vitiligo; LUSC cis rs13191362 0.573 rs1877769 chr6:163252315 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.33 5.98 0.31 5.6e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg26977086 chr12:132329805 MMP17 0.26 5.85 0.3 1.19e-8 Migraine; LUSC trans rs61931739 0.513 rs2200555 chr12:33899381 C/G cg13010199 chr12:38710504 ALG10B 0.48 7.56 0.38 3.82e-13 Morning vs. evening chronotype; LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.5 0.62 2.75e-37 Platelet count; LUSC cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg15395560 chr15:45543142 SLC28A2 0.33 5.66 0.3 3.25e-8 Uric acid levels; LUSC trans rs7824557 0.933 rs6601576 chr8:11100275 A/T cg15556689 chr8:8085844 FLJ10661 -0.53 -8.25 -0.41 3.65e-15 Retinal vascular caliber; LUSC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9467773 0.587 rs10946813 chr6:26345141 A/G cg05738196 chr6:26577821 NA 0.49 7.7 0.39 1.54e-13 Intelligence (multi-trait analysis); LUSC cis rs6087771 0.650 rs6060395 chr20:30219823 G/C cg13852791 chr20:30311386 BCL2L1 0.86 11.5 0.53 5.04e-26 Subcortical brain region volumes;Putamen volume; LUSC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg19052272 chr2:3704530 ALLC -0.51 -8.46 -0.42 8.67e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg07157834 chr1:205819609 PM20D1 0.81 14.1 0.61 9.44e-36 Menarche (age at onset); LUSC trans rs2197308 0.692 rs7488528 chr12:37912971 G/A cg06521331 chr12:34319734 NA -0.41 -6.23 -0.32 1.39e-9 Morning vs. evening chronotype; LUSC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.51 -0.34 2.75e-10 Neutrophil percentage of white cells; LUSC cis rs4144743 1.000 rs4144744 chr17:45323262 A/G cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs10782582 0.609 rs1770882 chr1:76411549 G/A cg10523679 chr1:76189770 ACADM -0.45 -6.61 -0.34 1.49e-10 Daytime sleep phenotypes; LUSC cis rs11971779 0.553 rs11973507 chr7:139099461 A/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6714788 0.523 rs6542905 chr2:100654707 C/G cg07810366 chr2:100720526 AFF3 -0.39 -6.08 -0.32 3.25e-9 Intelligence (multi-trait analysis); LUSC trans rs62458065 0.513 rs10245103 chr7:32534829 T/G cg00845942 chr12:64062724 DPY19L2 -0.53 -6.62 -0.34 1.47e-10 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg08807101 chr21:30365312 RNF160 -0.67 -11.95 -0.55 1.23e-27 Dental caries; LUSC cis rs240764 0.817 rs239245 chr6:101090377 C/A cg09795085 chr6:101329169 ASCC3 0.42 6.12 0.32 2.68e-9 Neuroticism; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg16393715 chr7:1948819 MAD1L1 -0.41 -7.05 -0.36 1.02e-11 Bipolar disorder and schizophrenia; LUSC cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12422267 0.536 rs61944635 chr12:132575652 C/T cg26561844 chr12:132562101 EP400 -0.57 -5.66 -0.3 3.3e-8 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg05283184 chr6:79620031 NA 0.54 11.07 0.52 1.75e-24 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22927696 chr12:45269992 NELL2 -0.43 -6.57 -0.34 1.98e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg25233709 chr10:116636983 FAM160B1 0.44 7.89 0.4 4.28e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs27434 0.583 rs149544 chr5:96157854 C/G cg16492584 chr5:96139282 ERAP1 -0.56 -7.53 -0.38 4.91e-13 Ankylosing spondylitis; LUSC cis rs11024102 1.000 rs11024102 chr11:17008605 T/C cg15084286 chr11:17036142 PLEKHA7 0.44 5.86 0.31 1.1e-8 Glaucoma (primary angle closure); LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg07701084 chr6:150067640 NUP43 0.57 8.88 0.44 4.29e-17 Lung cancer; LUSC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg20135002 chr11:47629003 NA -0.52 -8.12 -0.41 8.82e-15 Subjective well-being; LUSC cis rs1215050 0.791 rs1215054 chr4:98863009 T/G cg05340658 chr4:99064831 C4orf37 -0.44 -6.93 -0.35 2.18e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2236918 0.710 rs1776138 chr1:242027075 G/A cg17736920 chr1:242011382 EXO1 0.42 6.76 0.35 5.99e-11 Menopause (age at onset); LUSC cis rs34779708 0.966 rs12773647 chr10:35440327 A/G cg04310649 chr10:35416472 CREM -0.4 -6.25 -0.32 1.23e-9 Inflammatory bowel disease;Crohn's disease; LUSC trans rs12439619 0.705 rs17354185 chr15:82426170 C/G cg04831495 chr15:85060580 GOLGA6L5 0.49 6.35 0.33 7.02e-10 Intelligence (multi-trait analysis); LUSC cis rs2742234 0.541 rs11238490 chr10:43747598 G/A cg15436174 chr10:43711423 RASGEF1A 0.43 6.83 0.35 4.03e-11 Hirschsprung disease; LUSC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg05973401 chr12:123451056 ABCB9 0.55 6.81 0.35 4.68e-11 Neutrophil percentage of white cells; LUSC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs9393777 0.623 rs9358948 chr6:26483806 G/A cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg15556689 chr8:8085844 FLJ10661 0.61 9.61 0.47 1.88e-19 Joint mobility (Beighton score); LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg00166722 chr3:10149974 C3orf24 0.56 7.57 0.38 3.75e-13 Alzheimer's disease; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg15117754 chr3:10150083 C3orf24 0.43 5.69 0.3 2.82e-8 Alzheimer's disease; LUSC trans rs9393777 0.920 rs13191227 chr6:27390115 G/C cg01620082 chr3:125678407 NA -0.79 -6.92 -0.35 2.32e-11 Intelligence (multi-trait analysis); LUSC cis rs11711311 0.955 rs1048892 chr3:113464859 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 7.02 0.36 1.25e-11 IgG glycosylation; LUSC cis rs8005677 1.000 rs4982709 chr14:23394699 C/T cg00579484 chr14:23475993 C14orf93 0.4 5.96 0.31 6.38e-9 Cognitive ability (multi-trait analysis); LUSC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg11764359 chr7:65958608 NA -0.68 -11.05 -0.52 2.2e-24 Aortic root size; LUSC cis rs2952156 0.920 rs2247862 chr17:37829129 A/G cg00129232 chr17:37814104 STARD3 -0.43 -6.35 -0.33 7.24e-10 Asthma; LUSC trans rs7726839 0.540 rs7434 chr5:660804 A/G cg11887960 chr12:57824829 NA -0.52 -6.69 -0.34 9.6e-11 Obesity-related traits; LUSC cis rs59104589 0.617 rs7568 chr2:242291743 A/G cg14842376 chr2:242211374 HDLBP 0.55 6.24 0.32 1.3e-9 Fibrinogen levels; LUSC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.7 6.6 0.34 1.61e-10 Cerebrospinal P-tau181p levels; LUSC cis rs4604732 0.527 rs79329288 chr1:247626513 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs17685 0.672 rs1639618 chr7:75701987 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.57e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg04756594 chr16:24857601 SLC5A11 0.47 6.94 0.35 2.05e-11 Intelligence (multi-trait analysis); LUSC cis rs877282 0.898 rs34490091 chr10:765800 A/C cg17470449 chr10:769945 NA 0.53 7.09 0.36 8.21e-12 Uric acid levels; LUSC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg02772935 chr3:125709198 NA -0.49 -5.92 -0.31 7.84e-9 Blood pressure (smoking interaction); LUSC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg16520312 chr17:43971471 MAPT;LOC100128977 -0.38 -6.43 -0.33 4.51e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1395 0.778 rs2580759 chr2:27432500 G/T cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.47 -7.28 -0.37 2.44e-12 Blood metabolite levels; LUSC cis rs41271473 0.898 rs3738073 chr1:228871693 C/T cg10167378 chr1:228756711 NA 0.55 6.58 0.34 1.84e-10 Chronic lymphocytic leukemia; LUSC cis rs9359856 0.636 rs9294440 chr6:90308666 C/G cg13799429 chr6:90582589 CASP8AP2 0.71 7.6 0.38 3.07e-13 Bipolar disorder; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.66 10.12 0.48 3.51e-21 Lymphocyte counts; LUSC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg11764359 chr7:65958608 NA 0.79 12.7 0.57 1.97e-30 Aortic root size; LUSC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.12 0.52 1.15e-24 Menopause (age at onset); LUSC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg00255919 chr5:131827918 IRF1 0.43 8.25 0.41 3.62e-15 Asthma (sex interaction); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12498453 chr20:61557976 DIDO1 0.75 5.97 0.31 6.1e-9 Cognitive performance; LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg02018176 chr4:1364513 KIAA1530 0.58 10.23 0.49 1.46e-21 Longevity; LUSC cis rs17014483 0.749 rs3017905 chr4:89632132 C/G cg01026744 chr4:89619053 NAP1L5;HERC3 0.68 5.97 0.31 5.92e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs80282103 0.764 rs12244052 chr10:1103266 G/A cg08668510 chr10:1095578 IDI1 0.73 6.4 0.33 5.18e-10 Glomerular filtration rate (creatinine); LUSC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg12615879 chr12:58013172 SLC26A10 -0.27 -5.7 -0.3 2.66e-8 Multiple sclerosis; LUSC cis rs1729407 0.741 rs1263177 chr11:116690712 C/T cg08985259 chr11:116699649 APOC3 -0.25 -5.83 -0.3 1.3e-8 Apolipoprotein A-IV levels; LUSC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg06481639 chr22:41940642 POLR3H -0.46 -5.68 -0.3 2.97e-8 Vitiligo; LUSC cis rs17125944 0.505 rs80211268 chr14:53265483 C/G cg13660082 chr14:53194042 PSMC6 -0.77 -6.7 -0.34 8.66e-11 Alzheimer's disease (late onset); LUSC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg09998033 chr7:158218633 PTPRN2 0.57 9.11 0.45 7.93e-18 Obesity-related traits; LUSC cis rs926938 0.618 rs3121506 chr1:115363207 T/G cg12756093 chr1:115239321 AMPD1 0.53 7.92 0.4 3.61e-14 Autism; LUSC cis rs9303401 0.527 rs12946522 chr17:56768103 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.83 12.91 0.58 3.23e-31 Cognitive test performance; LUSC cis rs57221529 0.766 rs12519469 chr5:581772 A/G cg16447950 chr5:562315 NA -0.55 -6.63 -0.34 1.38e-10 Lung disease severity in cystic fibrosis; LUSC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg08219700 chr8:58056026 NA 0.5 6.28 0.33 1.03e-9 Developmental language disorder (linguistic errors); LUSC cis rs2731664 0.792 rs1130857 chr5:176863519 G/C cg23176889 chr5:176863531 GRK6 -0.7 -14.83 -0.63 1.34e-38 Intelligence (multi-trait analysis); LUSC cis rs2130392 0.926 rs10428357 chr4:185636217 T/A cg04058563 chr4:185651563 MLF1IP 0.42 6.88 0.35 3.01e-11 Kawasaki disease; LUSC cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs28647808 0.748 rs28721280 chr9:136267318 C/G cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg00339695 chr16:24857497 SLC5A11 0.38 6.66 0.34 1.15e-10 Intelligence (multi-trait analysis); LUSC cis rs11971779 0.680 rs7804388 chr7:139086413 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg10578991 chr7:12443926 VWDE -0.48 -5.85 -0.3 1.2e-8 Coronary artery disease; LUSC cis rs6494488 0.500 rs72744726 chr15:65030995 C/T cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg21733973 chr7:65235735 NA -0.42 -6.06 -0.31 3.71e-9 Calcium levels; LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg07507251 chr3:52567010 NT5DC2 0.31 6.12 0.32 2.59e-9 Bipolar disorder; LUSC cis rs6456156 0.742 rs6456157 chr6:167527818 C/A cg07741184 chr6:167504864 NA -0.37 -6.51 -0.34 2.78e-10 Primary biliary cholangitis; LUSC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.67 -0.34 1.04e-10 Total body bone mineral density; LUSC cis rs1018836 0.923 rs1476427 chr8:91552791 A/G cg16814680 chr8:91681699 NA 0.77 12.98 0.58 1.82e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7759001 0.817 rs6456774 chr6:27344831 C/G cg18711553 chr6:27366782 ZNF391 0.41 5.95 0.31 6.67e-9 Glomerular filtration rate (creatinine); LUSC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg02782426 chr3:40428986 ENTPD3 0.43 7.98 0.4 2.44e-14 Renal cell carcinoma; LUSC cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg23992470 chr4:843637 GAK 0.6 6.42 0.33 4.58e-10 Intelligence (multi-trait analysis); LUSC cis rs892961 1.000 rs1110638 chr17:75400690 T/C cg05865280 chr17:75406074 SEPT9 0.47 9.61 0.47 1.87e-19 Airflow obstruction; LUSC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11644478 chr21:40555479 PSMG1 -0.85 -15.47 -0.65 4.55e-41 Cognitive function; LUSC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg08508325 chr11:3079039 CARS -0.55 -14.02 -0.61 1.89e-35 Longevity; LUSC cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg18681998 chr4:17616180 MED28 0.84 15.64 0.65 9.43e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs11088226 0.681 rs2833911 chr21:33949629 C/T cg09050820 chr6:167586206 TCP10L2 -0.73 -9.52 -0.46 3.49e-19 Gastritis; LUSC cis rs9303401 0.659 rs62081314 chr17:56778328 A/G cg25039879 chr17:56429692 SUPT4H1 0.68 9.09 0.45 8.71e-18 Cognitive test performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14507132 chr15:57210852 TCF12;LOC145783 -0.43 -6.22 -0.32 1.46e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2204008 0.805 rs10881112 chr12:37956611 G/A cg26384229 chr12:38710491 ALG10B -0.81 -13.12 -0.58 5.39e-32 Bladder cancer; LUSC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg00409905 chr10:38381863 ZNF37A -0.36 -6.15 -0.32 2.24e-9 Extrinsic epigenetic age acceleration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26311208 chr1:59012484 OMA1 -0.57 -7.41 -0.38 1.01e-12 Bipolar disorder and schizophrenia; LUSC cis rs16958440 0.581 rs72907280 chr18:44681130 C/T cg17192377 chr18:44677553 HDHD2 0.52 6.12 0.32 2.6e-9 Sitting height ratio; LUSC cis rs73200209 0.744 rs61939683 chr12:116508474 T/G cg01776926 chr12:116560359 MED13L -0.49 -6.03 -0.31 4.4e-9 Total body bone mineral density; LUSC cis rs2235544 0.542 rs679801 chr1:54470757 T/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs7119038 0.818 rs17122453 chr11:118683564 G/A cg19308663 chr11:118741387 NA 0.34 6.09 0.32 3.06e-9 Sjögren's syndrome; LUSC cis rs7241530 0.662 rs8096274 chr18:75909734 T/C cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC cis rs1559088 1.000 rs7260051 chr19:33550111 C/A cg27124370 chr19:33622961 WDR88 0.53 6.81 0.35 4.56e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3806843 0.966 rs2563264 chr5:140137503 T/G cg26395211 chr5:140044315 WDR55 0.38 5.78 0.3 1.76e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs3770081 1.000 rs3770066 chr2:86392350 A/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.75 -0.35 6.59e-11 Facial emotion recognition (sad faces); LUSC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg00784671 chr22:46762841 CELSR1 -0.62 -6.93 -0.35 2.23e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg14159672 chr1:205819179 PM20D1 0.43 5.97 0.31 5.99e-9 Menarche (age at onset); LUSC cis rs60154123 0.614 rs11119456 chr1:210458323 C/A cg22029157 chr1:209979665 IRF6 0.52 6.08 0.32 3.32e-9 Coronary artery disease; LUSC cis rs4654899 0.802 rs10737452 chr1:21199764 C/T cg01072550 chr1:21505969 NA 0.44 6.61 0.34 1.52e-10 Superior frontal gyrus grey matter volume; LUSC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.02 -0.31 4.61e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg04511125 chr2:88470314 THNSL2 -0.64 -9.2 -0.45 3.86e-18 Response to metformin (IC50); LUSC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg01097406 chr16:89675127 NA 0.33 6.28 0.33 1.04e-9 Vitiligo; LUSC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg09509183 chr1:209979624 IRF6 0.44 5.94 0.31 7.29e-9 Cleft lip with or without cleft palate; LUSC cis rs4654899 0.865 rs9426730 chr1:21452255 A/T cg02927042 chr1:21476669 EIF4G3 -0.35 -5.66 -0.3 3.27e-8 Superior frontal gyrus grey matter volume; LUSC cis rs2137920 0.945 rs2254412 chr10:50238272 C/T cg27141751 chr10:50231850 C10orf72 0.38 5.73 0.3 2.28e-8 Migraine with aura; LUSC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg15556689 chr8:8085844 FLJ10661 -0.6 -9.22 -0.45 3.54e-18 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg17279839 chr7:150038598 RARRES2 0.49 7.44 0.38 8.59e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg00277334 chr10:82204260 NA -0.93 -18.89 -0.72 1.19e-54 Post bronchodilator FEV1; LUSC cis rs10207628 0.653 rs7601287 chr2:127881243 G/A cg06223080 chr2:127868745 NA 0.38 6.58 0.34 1.79e-10 Psychosis and Alzheimer's disease; LUSC cis rs12579753 1.000 rs11519754 chr12:82209181 A/T cg21231944 chr12:82153410 PPFIA2 -0.38 -5.71 -0.3 2.56e-8 Resting heart rate; LUSC cis rs12472274 0.941 rs6748440 chr2:239100375 C/T cg17459225 chr2:239074497 NA 0.62 10.03 0.48 7.36e-21 Phospholipid levels (plasma); LUSC cis rs10208940 0.920 rs35118992 chr2:68699460 G/A cg12452813 chr2:68675892 NA 0.56 5.88 0.31 1.01e-8 Urate levels in lean individuals; LUSC trans rs17086172 0.841 rs76610733 chr18:70268315 C/G cg00123055 chr8:55370951 SOX17 -0.68 -6.08 -0.32 3.31e-9 Airflow obstruction; LUSC trans rs931812 0.825 rs34153562 chr8:101893441 T/C cg20993868 chr7:22813445 NA 0.59 10.4 0.49 4.05e-22 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs72792276 1.000 rs17164395 chr5:127395526 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.9 7.72 0.39 1.36e-13 Red cell distribution width; LUSC cis rs2835872 0.758 rs1787399 chr21:39037883 A/G cg20424643 chr21:39039972 KCNJ6 -0.45 -7.47 -0.38 7.24e-13 Electroencephalographic traits in alcoholism; LUSC cis rs950169 0.845 rs4502182 chr15:84923520 A/G cg12863693 chr15:85201151 NMB 0.37 7.29 0.37 2.24e-12 Schizophrenia; LUSC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg18876405 chr7:65276391 NA 0.75 13.57 0.6 1.01e-33 Calcium levels; LUSC cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg00530320 chr1:46809349 NSUN4 -0.54 -8.5 -0.42 6.35e-16 Menopause (age at onset); LUSC cis rs6500395 0.963 rs2883642 chr16:48685146 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.84 -0.35 3.77e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs17401966 0.597 rs6667639 chr1:10246471 C/A cg19773385 chr1:10388646 KIF1B -0.42 -7.36 -0.37 1.48e-12 Hepatocellular carcinoma; LUSC trans rs12509991 0.741 rs17010688 chr4:127024000 A/T cg17848407 chr5:126408806 FLJ44606 0.46 5.97 0.31 6.02e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7903847 0.620 rs10882903 chr10:99115584 A/T cg08345082 chr10:99160200 RRP12 -0.36 -7.28 -0.37 2.43e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.37e-34 Diabetic kidney disease; LUSC cis rs3768617 0.510 rs3768621 chr1:183090057 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg12639453 chr1:2035780 PRKCZ -0.34 -7.29 -0.37 2.23e-12 Height; LUSC cis rs12971120 0.838 rs3794950 chr18:72182965 G/A cg25817165 chr18:72167213 CNDP2 -0.72 -8.06 -0.4 1.34e-14 Refractive error; LUSC cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.81 0.35 4.44e-11 Rheumatoid arthritis; LUSC cis rs11112613 0.609 rs11112585 chr12:105933442 A/G cg03607813 chr12:105948248 NA -0.7 -8.96 -0.44 2.4e-17 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs10465746 0.780 rs1570691 chr1:84370393 A/C cg10977910 chr1:84465055 TTLL7 0.44 6.23 0.32 1.42e-9 Obesity-related traits; LUSC cis rs6076065 0.802 rs2424527 chr20:23357329 A/C cg11657817 chr20:23433608 CST11 0.55 11.39 0.53 1.33e-25 Facial morphology (factor 15, philtrum width); LUSC cis rs2235649 0.798 rs78540053 chr16:1853275 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -5.82 -0.3 1.41e-8 Blood metabolite levels; LUSC cis rs10876993 0.806 rs1689598 chr12:58050500 G/C cg15848620 chr12:58087721 OS9 -0.53 -7.64 -0.39 2.36e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg00990874 chr7:1149470 C7orf50 -0.51 -6.36 -0.33 6.76e-10 Bronchopulmonary dysplasia; LUSC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11890956 chr21:40555474 PSMG1 -0.72 -10.81 -0.51 1.47e-23 Menarche (age at onset); LUSC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg05623727 chr3:50126028 RBM5 -0.33 -6.21 -0.32 1.54e-9 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg03806693 chr22:41940476 POLR3H -0.92 -13.2 -0.59 2.68e-32 Vitiligo; LUSC cis rs208520 0.837 rs208498 chr6:66931560 G/A cg07460842 chr6:66804631 NA -1.0 -14.14 -0.61 6.61e-36 Exhaled nitric oxide output; LUSC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg05084668 chr3:125655381 ALG1L -0.51 -7.15 -0.36 5.46e-12 Blood pressure (smoking interaction); LUSC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg08859206 chr1:53392774 SCP2 0.52 9.03 0.44 1.39e-17 Monocyte count; LUSC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg21361702 chr7:150065534 REPIN1 0.5 6.79 0.35 5.18e-11 Blood protein levels;Circulating chemerin levels; LUSC trans rs61931739 0.853 rs10844751 chr12:34099651 T/G cg13010199 chr12:38710504 ALG10B -0.46 -7.25 -0.37 2.83e-12 Morning vs. evening chronotype; LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.75 0.65 3.43e-42 Platelet count; LUSC cis rs9527 0.614 rs2153774 chr10:104881035 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.77 -9.84 -0.47 3.04e-20 Alzheimer's disease; LUSC cis rs250677 0.522 rs4705301 chr5:148354902 C/G cg18129178 chr5:148520854 ABLIM3 -0.52 -7.38 -0.37 1.23e-12 Breast cancer; LUSC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg04450456 chr4:17643702 FAM184B 0.43 7.21 0.37 3.8e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2262909 0.719 rs12461632 chr19:22245089 G/A cg11619707 chr19:22235551 ZNF257 0.4 6.0 0.31 5e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25789201 chr7:72395803 POM121 0.43 6.26 0.32 1.16e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7829975 0.774 rs11775523 chr8:8679176 A/G cg06636001 chr8:8085503 FLJ10661 0.6 9.1 0.45 8.61e-18 Mood instability; LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.27 0.37 2.58e-12 Bipolar disorder; LUSC cis rs2273669 0.667 rs12206423 chr6:109353216 C/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs10927875 0.929 rs4661674 chr1:16296039 A/G cg22431228 chr1:16359049 CLCNKA 0.45 8.79 0.43 8.09e-17 Dilated cardiomyopathy; LUSC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg20933634 chr6:27740509 NA 0.43 5.65 0.3 3.37e-8 Parkinson's disease; LUSC cis rs4423214 0.592 rs11234027 chr11:71234107 G/A cg05163923 chr11:71159392 DHCR7 -0.69 -7.12 -0.36 6.62e-12 Vitamin D levels; LUSC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg02569458 chr12:86230093 RASSF9 0.54 9.21 0.45 3.78e-18 Major depressive disorder; LUSC cis rs8072100 0.688 rs12602134 chr17:45582136 C/G cg25173405 chr17:45401733 C17orf57 0.36 5.71 0.3 2.56e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11122272 0.705 rs2491411 chr1:231533448 C/G cg06096015 chr1:231504339 EGLN1 0.58 10.37 0.49 5e-22 Hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02529627 chr17:1618713 C17orf91;WDR81;MIR22 0.43 6.12 0.32 2.69e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs61931739 0.500 rs11053193 chr12:34438838 G/T cg06521331 chr12:34319734 NA -0.4 -6.26 -0.32 1.2e-9 Morning vs. evening chronotype; LUSC cis rs9790314 0.846 rs4856714 chr3:160961824 T/C cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 4.11e-20 Morning vs. evening chronotype; LUSC cis rs950893 0.597 rs2942219 chr8:23439308 A/G cg08026493 chr8:23430824 NA 0.35 5.68 0.3 2.91e-8 Mean corpuscular hemoglobin; LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -8.93 -0.44 2.88e-17 Bipolar disorder and schizophrenia; LUSC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg19920283 chr7:105172520 RINT1 0.57 6.09 0.32 3.12e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9326248 1.000 rs7946257 chr11:117053165 A/G cg16524733 chr11:117070046 TAGLN 0.42 7.33 0.37 1.74e-12 Blood protein levels; LUSC cis rs6076065 0.676 rs6076057 chr20:23335982 G/T cg11657817 chr20:23433608 CST11 -0.44 -8.05 -0.4 1.49e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg15110403 chr19:17392923 ANKLE1 -0.59 -8.02 -0.4 1.85e-14 Systemic lupus erythematosus; LUSC trans rs11098499 0.909 rs9994810 chr4:120381590 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.02 0.4 1.78e-14 Corneal astigmatism; LUSC cis rs67460515 0.563 rs11720263 chr3:160848293 T/C cg03342759 chr3:160939853 NMD3 -0.45 -6.33 -0.33 7.76e-10 Parkinson's disease; LUSC cis rs13089785 1.000 rs13092912 chr3:123604942 C/T cg19611163 chr3:123411211 MYLK 0.35 5.9 0.31 8.73e-9 Intelligence (multi-trait analysis); LUSC cis rs877282 0.945 rs12767287 chr10:787310 A/G cg17470449 chr10:769945 NA 0.49 6.71 0.34 8.1e-11 Uric acid levels; LUSC cis rs7291412 0.929 rs7289457 chr22:46456603 C/T cg23691090 chr22:46449981 C22orf26;LOC150381 0.47 7.74 0.39 1.17e-13 Dupuytren's disease;Subjective well-being; LUSC cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.85 0.39 5.64e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC cis rs13315871 0.929 rs71311853 chr3:58319152 C/T cg12435725 chr3:58293450 RPP14 -0.72 -7.21 -0.37 3.87e-12 Cholesterol, total; LUSC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg26513180 chr16:89883248 FANCA 0.79 6.37 0.33 6.26e-10 Skin colour saturation; LUSC trans rs1814175 0.817 rs2866545 chr11:49630824 A/C cg03929089 chr4:120376271 NA -1.01 -19.18 -0.72 8.42e-56 Height; LUSC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg23188684 chr11:67383651 NA -0.37 -6.58 -0.34 1.81e-10 Mean corpuscular volume; LUSC cis rs10779751 0.960 rs1883964 chr1:11294942 T/A cg08854313 chr1:11322531 MTOR 0.87 15.21 0.64 4.52e-40 Body mass index; LUSC cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC trans rs7829975 0.755 rs3789849 chr8:8687054 G/C cg21775007 chr8:11205619 TDH 0.42 5.99 0.31 5.34e-9 Mood instability; LUSC cis rs2731664 0.792 rs2630765 chr5:176876825 T/C cg23176889 chr5:176863531 GRK6 -0.66 -13.54 -0.6 1.32e-33 Intelligence (multi-trait analysis); LUSC cis rs877282 0.853 rs11595510 chr10:756757 C/G cg17470449 chr10:769945 NA 0.51 7.04 0.36 1.1e-11 Uric acid levels; LUSC cis rs6429082 0.818 rs704722 chr1:235669988 G/A cg26050004 chr1:235667680 B3GALNT2 0.62 8.38 0.42 1.51e-15 Adiposity; LUSC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg11812906 chr14:75593930 NEK9 -0.63 -10.93 -0.51 5.52e-24 Height; LUSC cis rs7582180 0.629 rs11686842 chr2:100956139 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.73 0.3 2.29e-8 Intelligence (multi-trait analysis); LUSC trans rs28647808 0.881 rs7042326 chr9:136266636 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg10621924 chr7:39171070 POU6F2 0.49 7.73 0.39 1.32e-13 IgG glycosylation; LUSC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg02073558 chr3:44770973 ZNF501 0.58 9.73 0.47 7.34e-20 Depressive symptoms; LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.49 -0.59 2.14e-33 Alzheimer's disease; LUSC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg26769984 chr7:1090371 C7orf50 0.58 7.81 0.39 7.67e-14 Bronchopulmonary dysplasia; LUSC cis rs11971779 0.680 rs11760420 chr7:139114768 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg17330251 chr7:94953956 PON1 -0.37 -5.97 -0.31 6.03e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs4808199 0.947 rs7250658 chr19:19571100 A/G cg03709012 chr19:19516395 GATAD2A 1.11 14.26 0.62 2.29e-36 Nonalcoholic fatty liver disease; LUSC cis rs113835537 0.877 rs2275998 chr11:66326581 T/C cg24851651 chr11:66362959 CCS 0.47 6.08 0.32 3.29e-9 Airway imaging phenotypes; LUSC trans rs61931739 0.500 rs9705909 chr12:34576419 G/C cg13010199 chr12:38710504 ALG10B 0.67 10.35 0.49 5.86e-22 Morning vs. evening chronotype; LUSC cis rs752010 0.631 rs7515066 chr1:42076915 A/G cg06885757 chr1:42089581 HIVEP3 -0.62 -13.46 -0.59 2.73e-33 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2288073 0.930 rs7604097 chr2:24401805 G/C cg06627628 chr2:24431161 ITSN2 -0.74 -10.26 -0.49 1.16e-21 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs6546537 1.000 rs6546537 chr2:69839633 T/C cg10773587 chr2:69614142 GFPT1 -0.49 -7.5 -0.38 5.78e-13 Serum thyroid-stimulating hormone levels; LUSC cis rs9303401 0.659 rs1864754 chr17:56688789 G/T cg25039879 chr17:56429692 SUPT4H1 -0.67 -9.05 -0.44 1.22e-17 Cognitive test performance; LUSC cis rs2708977 0.692 rs17685766 chr2:97319534 G/C cg01950434 chr2:97203154 ARID5A 0.53 7.69 0.39 1.65e-13 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg14196790 chr5:131705035 SLC22A5 0.41 6.66 0.34 1.13e-10 Breast cancer;Mosquito bite size; LUSC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg04267008 chr7:1944627 MAD1L1 -0.51 -7.35 -0.37 1.52e-12 Schizophrenia; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg25703541 chr22:24373054 LOC391322 -0.89 -15.65 -0.65 8.55e-42 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg06618935 chr21:46677482 NA -0.4 -8.06 -0.4 1.37e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4595586 0.545 rs969469 chr12:39366775 A/C cg13010199 chr12:38710504 ALG10B 0.42 6.03 0.31 4.27e-9 Morning vs. evening chronotype; LUSC trans rs561341 0.714 rs547473 chr17:30297560 T/G cg20587970 chr11:113659929 NA -1.14 -15.67 -0.65 7.35e-42 Hip circumference adjusted for BMI; LUSC cis rs11098499 0.863 rs7664986 chr4:120429952 A/C cg09307838 chr4:120376055 NA 0.75 10.98 0.51 3.78e-24 Corneal astigmatism; LUSC cis rs5756813 0.635 rs4820301 chr22:38126364 G/A cg06521852 chr22:38141419 TRIOBP 0.4 5.93 0.31 7.63e-9 Optic cup area;Vertical cup-disc ratio; LUSC cis rs16937 0.662 rs11588199 chr1:205164580 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.45 0.33 4e-10 Schizophrenia; LUSC cis rs6138458 1.000 rs6114988 chr20:24977586 C/T cg06937882 chr20:24974362 C20orf3 -0.44 -7.67 -0.39 1.89e-13 Blood protein levels; LUSC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg00800038 chr16:89945340 TCF25 -0.75 -6.56 -0.34 2.08e-10 Skin colour saturation; LUSC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg18252515 chr7:66147081 NA 1.2 13.15 0.58 4.19e-32 Diabetic kidney disease; LUSC trans rs17645023 1.000 rs17645023 chr17:64917033 A/T cg22953960 chr10:22766081 NA -0.3 -6.14 -0.32 2.28e-9 Bipolar disorder and schizophrenia; LUSC cis rs7106204 0.686 rs12803558 chr11:24288205 C/A ch.11.24196551F chr11:24239977 NA 0.73 5.89 0.31 9.68e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1559088 0.947 rs7259879 chr19:33549462 T/C cg03563238 chr19:33554763 RHPN2 -0.4 -6.39 -0.33 5.41e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10072221 1.000 rs10044370 chr5:75719788 A/G cg03132911 chr5:75698732 IQGAP2 -0.35 -5.86 -0.31 1.1e-8 Mean platelet volume; LUSC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg12705353 chr12:122356852 WDR66 -0.38 -5.65 -0.3 3.38e-8 Mean corpuscular volume; LUSC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.82 0.3 1.37e-8 Tonsillectomy; LUSC cis rs897984 0.609 rs57576577 chr16:31036367 G/A cg02466173 chr16:30829666 NA -0.53 -10.43 -0.5 3.1e-22 Dementia with Lewy bodies; LUSC cis rs6582630 0.563 rs923281 chr12:38590241 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.75 -0.35 6.64e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs9814567 0.752 rs7633868 chr3:134331048 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs8060686 0.516 rs7184821 chr16:68270229 T/C cg09835421 chr16:68378352 PRMT7 -0.48 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs603424 0.597 rs574122 chr10:102089174 C/A cg10365880 chr10:102089681 PKD2L1 0.6 6.95 0.36 1.91e-11 Phospholipid levels (plasma);Palmitic acid (16:0) levels;Palmitoleic acid (16:1n-7) levels;Mean platelet volume;Serum metabolite levels;Blood metabolite levels;Vaccenic acid (18:1n-7) levels;Metabolic traits;Coronary artery disease;Blood metabolite ratios;Glycerophospholipid levels; LUSC cis rs6500395 1.000 rs3848322 chr16:48620964 C/A cg04672837 chr16:48644449 N4BP1 0.5 7.54 0.38 4.58e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg14893161 chr1:205819251 PM20D1 0.59 10.14 0.49 3.12e-21 Menarche (age at onset); LUSC cis rs477692 0.789 rs506915 chr10:131398005 A/G cg11019008 chr10:131425282 MGMT 0.44 6.7 0.34 8.65e-11 Response to temozolomide; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13479780 chr6:41909532 CCND3 -0.4 -5.95 -0.31 6.89e-9 Electrocardiographic conduction measures; LUSC cis rs6469656 0.892 rs10085939 chr8:117684153 C/T cg24004040 chr8:117650383 NA -0.43 -6.31 -0.33 9.04e-10 Colorectal cancer; LUSC cis rs6754311 0.731 rs3769005 chr2:136603366 C/G cg15123519 chr2:136567270 LCT 0.37 5.73 0.3 2.25e-8 Mosquito bite size; LUSC cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg25817165 chr18:72167213 CNDP2 -0.75 -11.42 -0.53 1.01e-25 Refractive error; LUSC cis rs9308433 0.529 rs6660335 chr1:214501855 C/T cg06198575 chr1:214491504 SMYD2 0.45 7.02 0.36 1.24e-11 IgG glycosylation; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06874399 chr5:79704109 ZFYVE16 0.4 6.05 0.31 3.94e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg16083849 chr15:59063210 FAM63B 0.58 7.0 0.36 1.38e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1865760 0.713 rs1130000 chr6:25985396 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 6.83 0.35 4.07e-11 Height; LUSC cis rs2795502 1.000 rs3121323 chr10:43377166 A/G cg27426351 chr10:43362370 NA -0.42 -5.73 -0.3 2.26e-8 Blood protein levels; LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs11677370 0.603 rs10164826 chr2:3849951 G/C cg17052675 chr2:3827356 NA -0.64 -10.2 -0.49 1.87e-21 Type 2 diabetes; LUSC cis rs2116941 1.000 rs8104426 chr19:10338676 G/T cg01850179 chr19:10340795 S1PR2 0.72 13.13 0.58 4.83e-32 Pulse pressure; LUSC cis rs9660992 0.573 rs12144980 chr1:205185104 C/T cg00857998 chr1:205179979 DSTYK 0.63 9.68 0.47 1.11e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg09796270 chr17:17721594 SREBF1 0.43 7.5 0.38 5.86e-13 Total body bone mineral density; LUSC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg22029157 chr1:209979665 IRF6 0.71 8.39 0.42 1.39e-15 Coronary artery disease; LUSC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg18876405 chr7:65276391 NA -0.55 -8.77 -0.43 9.25e-17 Aortic root size; LUSC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg21435336 chr19:17392852 ANKLE1 -0.47 -6.33 -0.33 7.95e-10 Systemic lupus erythematosus; LUSC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs7100689 0.753 rs1856773 chr10:82060484 T/A cg00277334 chr10:82204260 NA -0.53 -7.33 -0.37 1.73e-12 Post bronchodilator FEV1; LUSC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg01411255 chr17:61851458 DDX42;CCDC47 1.05 22.14 0.77 1.81e-67 Height; LUSC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg17294928 chr15:75287854 SCAMP5 0.41 5.88 0.31 1e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg03806693 chr22:41940476 POLR3H 1.01 13.96 0.61 3.31e-35 Vitiligo; LUSC cis rs2236918 1.000 rs2236918 chr1:242017826 C/G cg17736920 chr1:242011382 EXO1 -0.44 -6.92 -0.35 2.29e-11 Menopause (age at onset); LUSC cis rs1670533 0.872 rs11727136 chr4:1051804 G/A cg27284194 chr4:1044797 NA 0.55 7.97 0.4 2.57e-14 Recombination rate (females); LUSC cis rs6681460 0.966 rs10749765 chr1:67150280 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.87 0.44 4.51e-17 Presence of antiphospholipid antibodies; LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg21782813 chr7:2030301 MAD1L1 0.35 5.85 0.3 1.19e-8 Bipolar disorder and schizophrenia; LUSC cis rs10193935 0.901 rs997288 chr2:42525582 C/G cg27598129 chr2:42591480 NA -0.58 -7.9 -0.4 3.95e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09234622 chr22:39240094 NPTXR -0.42 -6.31 -0.33 8.96e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4343996 0.837 rs10228151 chr7:3472757 G/T cg21248987 chr7:3385318 SDK1 -0.39 -6.5 -0.33 3.01e-10 Motion sickness; LUSC cis rs7647973 0.566 rs57630346 chr3:49086215 T/C cg21141812 chr3:48556323 PFKFB4 0.36 6.07 0.32 3.42e-9 Menarche (age at onset); LUSC cis rs6940638 0.956 rs10946899 chr6:27023694 T/A cg05738196 chr6:26577821 NA -0.47 -5.77 -0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.602 rs1727296 chr12:123647725 G/C cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.12 -0.32 2.63e-9 Neutrophil percentage of white cells; LUSC cis rs472402 0.560 rs10065299 chr5:6654489 T/C cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.54 -7.77 -0.39 1.01e-13 Response to amphetamines; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17960051 chr7:87257673 ABCB1;RUNDC3B 0.47 6.86 0.35 3.39e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg13047869 chr3:10149882 C3orf24 0.63 9.07 0.44 1.02e-17 Alzheimer's disease; LUSC cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.3 6.71 0.34 8.24e-11 Coronary artery disease; LUSC cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -9.07 -0.44 1.08e-17 Axial length; LUSC cis rs79387448 0.745 rs78136548 chr2:103103740 T/G cg09003973 chr2:102972529 NA 1.0 9.33 0.45 1.52e-18 Gut microbiota (bacterial taxa); LUSC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.56 -8.66 -0.43 2.03e-16 Height; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14283194 chr7:91763737 CYP51A1 0.36 6.34 0.33 7.38e-10 Triglycerides; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.66 10.12 0.48 3.51e-21 Lymphocyte counts; LUSC cis rs9487051 0.768 rs371960 chr6:109525082 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.7 -0.3 2.69e-8 Reticulocyte fraction of red cells; LUSC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg09877947 chr5:131593287 PDLIM4 0.49 8.01 0.4 1.9e-14 Breast cancer; LUSC cis rs796364 0.806 rs55985986 chr2:201120987 A/C cg23649088 chr2:200775458 C2orf69 -0.53 -6.31 -0.33 8.85e-10 Schizophrenia; LUSC cis rs765787 0.530 rs4514617 chr15:45535439 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.62 -0.43 2.8e-16 Uric acid levels; LUSC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg02782426 chr3:40428986 ENTPD3 0.39 7.45 0.38 8.01e-13 Renal cell carcinoma; LUSC cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.4 -6.11 -0.32 2.76e-9 Ulcerative colitis; LUSC cis rs9308433 0.529 rs10465697 chr1:214499948 T/C cg06198575 chr1:214491504 SMYD2 0.45 6.99 0.36 1.46e-11 IgG glycosylation; LUSC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg24110177 chr3:50126178 RBM5 -0.55 -9.03 -0.44 1.35e-17 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg21361702 chr7:150065534 REPIN1 0.47 5.92 0.31 7.88e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg20135002 chr11:47629003 NA -0.51 -7.98 -0.4 2.36e-14 Subjective well-being; LUSC trans rs8072100 0.967 rs4289035 chr17:45707211 C/T cg04995722 chr7:26192034 NFE2L3 -0.37 -6.16 -0.32 2.08e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs425277 0.958 rs262688 chr1:2113565 T/G cg24578937 chr1:2090814 PRKCZ 0.6 14.15 0.61 6.34e-36 Height; LUSC cis rs7119 0.604 rs2667781 chr15:77858619 A/C cg27398640 chr15:77910606 LINGO1 0.37 7.87 0.4 4.99e-14 Type 2 diabetes; LUSC cis rs983392 0.667 rs634475 chr11:59942081 G/A cg24026212 chr11:59952134 MS4A6A 0.34 6.03 0.31 4.27e-9 Alzheimer's disease (late onset); LUSC cis rs11971779 0.680 rs10085902 chr7:139109105 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs11711311 1.000 rs2603793 chr3:113496418 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.6 0.34 1.6e-10 IgG glycosylation; LUSC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg16339924 chr4:17578868 LAP3 0.54 8.12 0.41 9.26e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs61931739 0.559 rs4385974 chr12:34313128 G/C cg06521331 chr12:34319734 NA -0.4 -6.91 -0.35 2.47e-11 Morning vs. evening chronotype; LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg00814883 chr7:100076585 TSC22D4 -0.75 -10.25 -0.49 1.27e-21 Platelet count; LUSC cis rs6920965 0.507 rs9385388 chr6:126215296 C/T cg05901451 chr6:126070800 HEY2 -0.51 -7.46 -0.38 7.44e-13 High light scatter reticulocyte count; LUSC cis rs881375 1.000 rs881375 chr9:123652898 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.93 0.31 7.55e-9 Rheumatoid arthritis; LUSC cis rs500891 0.525 rs12524968 chr6:84076466 C/G cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs4285028 0.948 rs2091664 chr3:121684749 T/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.59 -0.46 2.19e-19 Multiple sclerosis; LUSC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.08 -0.32 3.25e-9 Alzheimer's disease (late onset); LUSC trans rs17685 0.672 rs10952841 chr7:75778626 A/C cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs11864453 0.713 rs12708926 chr16:72126063 T/C cg01557791 chr16:72042693 DHODH -0.52 -7.54 -0.38 4.42e-13 Fibrinogen levels; LUSC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg09455208 chr3:40491958 NA 0.57 10.01 0.48 8.12e-21 Renal cell carcinoma; LUSC cis rs72627509 0.857 rs55762216 chr4:57765731 G/C cg26694713 chr4:57773883 REST 0.53 6.31 0.33 9.03e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs73198271 0.562 rs35432123 chr8:8671018 G/T cg01851573 chr8:8652454 MFHAS1 0.65 8.41 0.42 1.23e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.61 -9.37 -0.46 1.1e-18 Personality dimensions; LUSC cis rs6537837 1.000 rs6537837 chr1:110119732 C/T cg05049280 chr1:110155535 GNAT2 0.5 6.73 0.35 7.44e-11 Major depressive disorder; LUSC cis rs8112211 0.954 rs7252835 chr19:38832946 G/A cg14299480 chr19:38876666 GGN -0.35 -6.02 -0.31 4.63e-9 Blood protein levels; LUSC cis rs9814567 0.702 rs9871226 chr3:134331466 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.62 -0.57 4.01e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs35110281 0.686 rs162399 chr21:44950020 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.48 0.53 6.39e-26 Mean corpuscular volume; LUSC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg14004847 chr7:1930337 MAD1L1 -0.58 -9.11 -0.45 7.67e-18 Schizophrenia; LUSC cis rs4595586 0.545 rs925827 chr12:39364307 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.33 0.33 7.88e-10 Morning vs. evening chronotype; LUSC cis rs3741151 0.686 rs17851510 chr11:73106294 A/C cg17517138 chr11:73019481 ARHGEF17 0.88 8.15 0.41 7.15e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg08470875 chr2:26401718 FAM59B -0.68 -9.16 -0.45 5.18e-18 Gut microbiome composition (summer); LUSC cis rs6494488 0.500 rs72744713 chr15:65015534 G/T cg08069370 chr15:64387884 SNX1 -0.66 -6.09 -0.32 3.06e-9 Coronary artery disease; LUSC trans rs853679 0.599 rs149990 chr6:27998258 G/A cg01620082 chr3:125678407 NA -0.62 -6.95 -0.36 1.94e-11 Depression; LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg21724239 chr8:58056113 NA 0.77 9.21 0.45 3.76e-18 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg02423579 chr7:2872169 GNA12 -0.44 -6.24 -0.32 1.32e-9 Height; LUSC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.44 -7.77 -0.39 9.89e-14 Eosinophil percentage of white cells; LUSC cis rs11587682 0.714 rs41264139 chr1:150460850 C/T cg11822372 chr1:151115635 SEMA6C -0.42 -5.71 -0.3 2.53e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6977660 0.652 rs10486362 chr7:19755224 A/G cg07541023 chr7:19748670 TWISTNB -0.93 -9.49 -0.46 4.39e-19 Thyroid stimulating hormone; LUSC cis rs6500602 0.647 rs1684600 chr16:4594671 C/T cg08645402 chr16:4508243 NA -0.44 -7.33 -0.37 1.79e-12 Schizophrenia; LUSC cis rs6964587 0.692 rs7807490 chr7:91773359 A/G cg17063962 chr7:91808500 NA 0.58 9.75 0.47 6.46e-20 Breast cancer; LUSC trans rs6089829 0.926 rs6011552 chr20:61667894 T/C cg15934090 chr1:100435551 SLC35A3 0.49 8.35 0.42 1.84e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9388451 0.874 rs1159974 chr6:126090277 C/T cg05901451 chr6:126070800 HEY2 0.93 18.33 0.71 1.99e-52 Brugada syndrome; LUSC cis rs77633900 0.772 rs157768 chr15:76833779 C/T cg21673338 chr15:77095150 SCAPER -0.71 -6.21 -0.32 1.58e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs11264213 0.901 rs631202 chr1:36449099 G/C cg27506609 chr1:36549197 TEKT2 0.62 7.23 0.37 3.37e-12 Schizophrenia; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg07362569 chr17:61921086 SMARCD2 0.36 7.58 0.38 3.47e-13 Prudent dietary pattern; LUSC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg14343924 chr8:8086146 FLJ10661 -0.42 -5.71 -0.3 2.5e-8 Mood instability; LUSC cis rs6964587 1.000 rs7785095 chr7:91640773 A/T cg01689657 chr7:91764605 CYP51A1 -0.31 -5.72 -0.3 2.36e-8 Breast cancer; LUSC cis rs924607 0.966 rs1709554 chr5:637443 A/G cg09021430 chr5:549028 NA -0.42 -7.49 -0.38 6.29e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg09826364 chr7:158789723 NA -0.38 -6.08 -0.32 3.3e-9 Facial morphology (factor 20); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27660165 chr1:156784036 SH2D2A 0.42 6.31 0.33 9.01e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.45 -6.4 -0.33 5.2400000000000005e-10 Alzheimer's disease (late onset); LUSC cis rs8099014 1.000 rs4940393 chr18:56109540 C/T cg12907477 chr18:56117327 MIR122 0.43 6.72 0.35 7.8e-11 Platelet count; LUSC trans rs6502050 0.842 rs7218075 chr17:80076808 C/G cg07393940 chr7:158741817 NA -0.36 -6.37 -0.33 6.38e-10 Life satisfaction; LUSC cis rs912057 1.000 rs1294410 chr6:6738752 C/T cg06612196 chr6:6737390 NA -0.55 -10.68 -0.5 4.13e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs968451 0.619 rs2267407 chr22:39747050 G/A cg17798944 chr22:39715225 SNORD43;RPL3 0.56 7.11 0.36 7.24e-12 Primary biliary cholangitis; LUSC cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.83 0.39 6.66e-14 Colorectal cancer; LUSC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg26769984 chr7:1090371 C7orf50 0.67 10.31 0.49 7.92e-22 Bronchopulmonary dysplasia; LUSC cis rs3858526 0.834 rs10838993 chr11:5979221 T/C cg02574844 chr11:5959923 NA -0.45 -6.26 -0.32 1.17e-9 DNA methylation (variation); LUSC cis rs12220238 1.000 rs12256105 chr10:75909634 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.27 0.37 2.54e-12 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13686143 chr2:201828163 ORC2L 0.45 6.43 0.33 4.38e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg11645453 chr3:52864694 ITIH4 -0.29 -6.28 -0.33 1.03e-9 Bipolar disorder; LUSC trans rs11700980 1.000 rs56103672 chr21:30122076 G/A cg05609335 chr17:75789393 NA 0.41 6.32 0.33 8.58e-10 QRS complex (12-leadsum); LUSC trans rs61931739 0.500 rs11053274 chr12:34547605 G/A cg26384229 chr12:38710491 ALG10B 0.88 14.87 0.63 9.73e-39 Morning vs. evening chronotype; LUSC cis rs1538970 0.781 rs11211139 chr1:46015751 G/T cg05343316 chr1:45956843 TESK2 0.7 9.29 0.45 2.04e-18 Platelet count; LUSC trans rs57046232 0.508 rs2148814 chr20:6352589 G/A cg21095983 chr6:86352623 SYNCRIP 0.46 6.97 0.36 1.67e-11 Colorectal cancer; LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg14433983 chr11:636460 DRD4 -0.35 -5.85 -0.31 1.15e-8 Systemic lupus erythematosus; LUSC cis rs11098499 0.954 rs12506546 chr4:120301618 T/C cg24375607 chr4:120327624 NA 0.75 10.83 0.51 1.25e-23 Corneal astigmatism; LUSC cis rs911555 0.755 rs8018400 chr14:103901085 A/G cg12935359 chr14:103987150 CKB 0.65 10.44 0.5 2.83e-22 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.697 rs9287620 chr2:238368730 C/T cg16989719 chr2:238392110 NA -0.38 -6.41 -0.33 4.88e-10 Prostate cancer; LUSC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.54 0.42 4.97e-16 Homoarginine levels; LUSC cis rs854765 0.663 rs16960744 chr17:17755259 A/G cg09796270 chr17:17721594 SREBF1 -0.46 -8.31 -0.41 2.42e-15 Total body bone mineral density; LUSC cis rs7944584 0.610 rs2596407 chr11:47361838 A/G cg20307385 chr11:47447363 PSMC3 -0.71 -10.92 -0.51 6.3e-24 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs11997175 0.574 rs7001404 chr8:33645219 G/A ch.8.33884649F chr8:33765107 NA 0.52 8.38 0.42 1.53e-15 Body mass index; LUSC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg25554036 chr4:6271136 WFS1 0.61 12.18 0.55 1.74e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs11039798 0.511 rs7948129 chr11:48167828 G/A cg03929089 chr4:120376271 NA -0.59 -6.42 -0.33 4.81e-10 Axial length; LUSC cis rs2228479 0.681 rs62052184 chr16:89967217 T/C cg26513180 chr16:89883248 FANCA 0.6 5.72 0.3 2.31e-8 Skin colour saturation; LUSC cis rs4899554 0.509 rs78368951 chr14:75730348 A/G cg18117039 chr14:75741733 NA 0.53 7.1 0.36 7.78e-12 Inflammatory bowel disease; LUSC cis rs4680 1.000 rs4633 chr22:19950235 C/T cg23601416 chr22:19950040 COMT 0.32 6.78 0.35 5.51e-11 Blood metabolite levels; LUSC cis rs3099143 1.000 rs3099134 chr15:77133168 T/G cg21673338 chr15:77095150 SCAPER -0.78 -7.26 -0.37 2.77e-12 Recalcitrant atopic dermatitis; LUSC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg24531977 chr5:56204891 C5orf35 -0.93 -10.72 -0.51 3.03e-23 Type 2 diabetes; LUSC cis rs7072216 0.763 rs1061437 chr10:100176154 C/T cg26618903 chr10:100175079 PYROXD2 -0.45 -8.52 -0.42 5.48e-16 Metabolite levels; LUSC cis rs62103177 0.810 rs62103195 chr18:77629693 T/C cg20368463 chr18:77673604 PQLC1 0.67 5.85 0.3 1.19e-8 Opioid sensitivity; LUSC cis rs7561273 0.586 rs12477718 chr2:24330539 A/G cg06627628 chr2:24431161 ITSN2 -0.52 -6.84 -0.35 3.89e-11 Quantitative traits; LUSC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg27170947 chr2:26402098 FAM59B -0.63 -9.18 -0.45 4.77e-18 Gut microbiome composition (summer); LUSC cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg16230307 chr14:35515116 FAM177A1 0.82 10.3 0.49 8.57e-22 Psoriasis; LUSC cis rs3772130 1.000 rs33988592 chr3:121415610 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.64 9.28 0.45 2.14e-18 Cognitive performance; LUSC cis rs1419980 0.643 rs10772588 chr12:7796738 G/A cg10578777 chr12:7781093 NA 0.61 5.72 0.3 2.34e-8 HDL cholesterol levels; LUSC cis rs34779708 0.931 rs2244100 chr10:35323636 G/A cg03585969 chr10:35415529 CREM -0.6 -8.81 -0.43 7.02e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11098499 0.954 rs10031665 chr4:120422852 T/C cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs11098499 0.863 rs3822194 chr4:120471648 A/G cg24375607 chr4:120327624 NA 0.75 11.23 0.52 5.02e-25 Corneal astigmatism; LUSC cis rs11214589 0.905 rs12805699 chr11:113241810 T/A cg14159747 chr11:113255604 NA 0.29 7.01 0.36 1.33e-11 Neuroticism; LUSC trans rs7618314 0.504 rs2922111 chr3:108533911 A/C cg05749855 chr16:89472771 ANKRD11 0.56 6.18 0.32 1.85e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg02475777 chr4:1388615 CRIPAK 0.62 9.24 0.45 2.93e-18 Longevity; LUSC cis rs599083 0.793 rs314750 chr11:68182028 G/A cg01657329 chr11:68192670 LRP5 0.51 7.5 0.38 5.81e-13 Bone mineral density (spine); LUSC cis rs12579753 0.917 rs10862361 chr12:82197946 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg22508957 chr16:3507546 NAT15 0.49 6.76 0.35 6.33e-11 Body mass index (adult); LUSC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg20295408 chr7:1910781 MAD1L1 -0.47 -6.48 -0.33 3.38e-10 Schizophrenia; LUSC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg06618935 chr21:46677482 NA -0.37 -7.33 -0.37 1.75e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs58235267 0.543 rs2539990 chr2:63170185 C/T cg17519650 chr2:63277830 OTX1 0.66 9.63 0.47 1.62e-19 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs11971779 0.680 rs10261557 chr7:139099037 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs4589502 0.800 rs2035150 chr15:67201794 A/C cg09911534 chr15:67153556 NA 0.51 6.58 0.34 1.78e-10 Lung cancer (smoking interaction); LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 15.03 0.64 2.29e-39 Platelet count; LUSC cis rs6570726 0.902 rs4895678 chr6:145935510 C/T cg23711669 chr6:146136114 FBXO30 0.74 12.36 0.56 3.86e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg00074818 chr8:8560427 CLDN23 0.58 9.66 0.47 1.23e-19 Obesity-related traits; LUSC cis rs10203711 1.000 rs6716457 chr2:239577621 C/T cg14580085 chr2:239553406 NA 0.42 7.11 0.36 7.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs8032158 0.574 rs56093337 chr15:56133199 A/T cg05129572 chr15:56138634 NEDD4 -0.4 -5.84 -0.3 1.26e-8 Keloid; LUSC cis rs6987853 0.736 rs6991995 chr8:42436219 A/C cg09913449 chr8:42400586 C8orf40 0.53 9.23 0.45 3.26e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs3741151 0.773 rs73548688 chr11:73279544 C/T cg17517138 chr11:73019481 ARHGEF17 0.98 8.21 0.41 4.85e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2562456 0.920 rs2650784 chr19:21666597 T/C cg00806126 chr19:22604979 ZNF98 0.36 5.81 0.3 1.49e-8 Pain; LUSC trans rs9929218 0.551 rs2296409 chr16:68713730 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.07 25.83 0.82 1.3e-81 Colorectal cancer; LUSC cis rs11625487 0.609 rs17824567 chr14:77976450 G/T cg16049707 chr14:77965284 ISM2 0.61 6.74 0.35 6.99e-11 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs7927771 0.524 rs6485773 chr11:47763509 A/G cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs34734847 0.842 rs696337 chr12:121159380 T/C cg21892295 chr12:121157589 UNC119B -0.36 -6.31 -0.33 9.08e-10 Mean corpuscular volume; LUSC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg04025307 chr7:1156635 C7orf50 0.43 6.48 0.33 3.33e-10 Bronchopulmonary dysplasia; LUSC cis rs9527 0.590 rs7901197 chr10:104840433 C/T cg05855489 chr10:104503620 C10orf26 0.53 7.96 0.4 2.73e-14 Arsenic metabolism; LUSC cis rs3755132 0.929 rs976016 chr2:15772865 A/G cg12888861 chr2:15731646 DDX1 0.5 7.17 0.37 5e-12 Wilms tumor; LUSC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg21573476 chr21:45109991 RRP1B -0.37 -6.01 -0.31 4.75e-9 Mean corpuscular volume; LUSC cis rs9920506 0.518 rs11072774 chr15:78952697 C/T cg04896959 chr15:78267971 NA -0.44 -7.47 -0.38 7.24e-13 Post bronchodilator FEV1; LUSC cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs9399401 0.677 rs6925979 chr6:142651052 G/A cg04461802 chr6:142623433 GPR126 0.47 5.95 0.31 6.76e-9 Chronic obstructive pulmonary disease; LUSC cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.18 0.55 1.76e-28 Motion sickness; LUSC cis rs4786125 0.596 rs12149100 chr16:6922512 T/G cg03623568 chr16:6915990 A2BP1 -0.5 -8.41 -0.42 1.22e-15 Heart rate variability traits (SDNN); LUSC cis rs6598955 0.543 rs60676610 chr1:26543421 G/C cg12744634 chr1:26560303 CCDC21 0.39 5.84 0.3 1.25e-8 Obesity-related traits; LUSC cis rs9325144 0.556 rs34565156 chr12:39028239 G/A cg13010199 chr12:38710504 ALG10B -0.52 -8.02 -0.4 1.81e-14 Morning vs. evening chronotype; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg01171360 chr6:293285 DUSP22 -0.68 -11.15 -0.52 9.34e-25 Menopause (age at onset); LUSC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg18404041 chr3:52824283 ITIH1 0.4 7.14 0.36 5.74e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg27539214 chr16:67997921 SLC12A4 -0.55 -7.36 -0.37 1.4e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs11690935 0.959 rs12185567 chr2:172560729 A/C cg13550731 chr2:172543902 DYNC1I2 0.89 14.72 0.63 3.87e-38 Schizophrenia; LUSC trans rs1728785 1.000 rs1645979 chr16:68603660 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.57 0.42 3.77e-16 Ulcerative colitis; LUSC cis rs8060686 0.565 rs55857142 chr16:68236741 A/T cg05110241 chr16:68378359 PRMT7 -0.61 -6.63 -0.34 1.37e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs3858526 0.834 rs7113548 chr11:5989293 G/A cg25319279 chr11:5960081 NA -0.45 -6.27 -0.32 1.09e-9 DNA methylation (variation); LUSC cis rs7904368 0.806 rs7899923 chr10:16857394 G/A cg14835575 chr10:16859367 RSU1 0.72 9.08 0.44 9.7e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs1044826 1.000 rs13083195 chr3:139067890 A/G cg00490450 chr3:139108681 COPB2 0.56 7.41 0.38 1.05e-12 Obesity-related traits; LUSC cis rs6121246 0.909 rs7272062 chr20:30259145 A/G cg18721089 chr20:30220636 NA -0.34 -5.86 -0.31 1.13e-8 Mean corpuscular hemoglobin; LUSC trans rs208520 0.837 rs208471 chr6:66916749 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -14.1 -0.61 9.35e-36 Exhaled nitric oxide output; LUSC trans rs1728785 1.000 rs864742 chr16:68575309 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.65 0.39 2.18e-13 Ulcerative colitis; LUSC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg24399712 chr22:39784796 NA -0.57 -10.04 -0.48 6.46e-21 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.754 rs12513083 chr4:120249612 A/T cg24375607 chr4:120327624 NA 0.75 12.14 0.55 2.34e-28 Corneal astigmatism; LUSC cis rs2980439 0.557 rs2921056 chr8:8319182 T/C cg08975724 chr8:8085496 FLJ10661 0.53 8.0 0.4 2.02e-14 Neuroticism; LUSC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg00310523 chr12:86230176 RASSF9 0.52 9.81 0.47 3.97e-20 Major depressive disorder; LUSC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08109568 chr15:31115862 NA 0.49 6.91 0.35 2.43e-11 Huntington's disease progression; LUSC cis rs7586879 0.638 rs10203482 chr2:25136916 T/C cg04586622 chr2:25135609 ADCY3 0.43 9.06 0.44 1.16e-17 Body mass index; LUSC cis rs666930 0.519 rs477992 chr1:120257576 A/G cg19096424 chr1:120255104 PHGDH 0.6 8.81 0.43 6.88e-17 Breast cancer; LUSC cis rs7180079 1.000 rs2062248 chr15:64672319 C/T cg02848875 chr15:64387786 SNX1 0.44 5.68 0.3 2.88e-8 Monocyte count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02632015 chr17:19551762 ALDH3A2 0.66 5.95 0.31 6.59e-9 Cognitive performance; LUSC cis rs4499344 0.633 rs411328 chr19:33140178 T/G cg22980127 chr19:33182716 NUDT19 -0.41 -6.08 -0.32 3.19e-9 Mean platelet volume; LUSC cis rs936229 0.861 rs7162232 chr15:75115895 G/A cg14664628 chr15:75095509 CSK -0.99 -16.84 -0.68 1.61e-46 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs644799 0.540 rs10831419 chr11:95478037 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.65 9.75 0.47 6.31e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs8073060 0.544 rs8071584 chr17:33999435 G/A cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7100689 0.646 rs7077712 chr10:82134894 A/G cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs41271473 1.000 rs72751929 chr1:228884358 A/G cg10167378 chr1:228756711 NA 0.54 6.54 0.34 2.33e-10 Chronic lymphocytic leukemia; LUSC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg24531977 chr5:56204891 C5orf35 -1.07 -15.85 -0.66 1.39e-42 Initial pursuit acceleration; LUSC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg22907277 chr7:1156413 C7orf50 0.66 7.25 0.37 2.83e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.53 0.38 4.76e-13 Colorectal cancer; LUSC cis rs614226 0.938 rs7963543 chr12:120923948 C/A cg21053147 chr12:120880522 NA -0.5 -6.22 -0.32 1.45e-9 Type 1 diabetes nephropathy; LUSC cis rs11971779 0.680 rs6949599 chr7:139054188 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs67311347 0.544 rs7644643 chr3:40350209 C/T cg09455208 chr3:40491958 NA -0.4 -7.41 -0.38 1.06e-12 Renal cell carcinoma; LUSC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg22166914 chr1:53195759 ZYG11B -0.69 -12.06 -0.55 4.87e-28 Monocyte count; LUSC cis rs8028313 0.731 rs7172055 chr15:67938334 G/C cg24579218 chr15:68104479 NA -0.36 -6.27 -0.32 1.13e-9 Obesity; LUSC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg01097406 chr16:89675127 NA 0.3 5.69 0.3 2.72e-8 Multiple myeloma (IgH translocation); LUSC cis rs1595825 0.628 rs6760078 chr2:198563742 A/T cg00982548 chr2:198649783 BOLL -0.55 -7.12 -0.36 6.68e-12 Ulcerative colitis; LUSC trans rs12310956 0.510 rs4931758 chr12:33871870 C/T cg26384229 chr12:38710491 ALG10B 0.54 8.35 0.42 1.9e-15 Morning vs. evening chronotype; LUSC cis rs4654899 0.865 rs12123300 chr1:21323568 T/C cg02927042 chr1:21476669 EIF4G3 -0.41 -6.52 -0.34 2.56e-10 Superior frontal gyrus grey matter volume; LUSC cis rs936229 0.871 rs2290574 chr15:75135447 T/C cg10253484 chr15:75165896 SCAMP2 -0.5 -6.55 -0.34 2.17e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9916302 0.653 rs11654954 chr17:37745979 C/T cg07936489 chr17:37558343 FBXL20 0.61 7.55 0.38 4.13e-13 Glomerular filtration rate (creatinine); LUSC cis rs6089584 0.830 rs6089309 chr20:60585687 T/C cg13770153 chr20:60521292 NA -0.61 -8.34 -0.42 1.99e-15 Body mass index; LUSC cis rs686320 1.000 rs35940245 chr11:65232673 G/A cg21890820 chr11:65308645 LTBP3 0.8 8.14 0.41 7.68e-15 Hip circumference adjusted for BMI; LUSC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg08886695 chr4:3369023 RGS12 -0.34 -5.68 -0.3 2.96e-8 Parental longevity (mother's age at death); LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg10802521 chr3:52805072 NEK4 -0.51 -7.98 -0.4 2.32e-14 Bipolar disorder; LUSC cis rs7011049 1.000 rs72640863 chr8:53841706 A/T cg26025543 chr8:53854495 NA 0.52 6.3 0.33 9.5e-10 Systolic blood pressure; LUSC cis rs1595825 0.786 rs1902246 chr2:198492827 C/T cg00982548 chr2:198649783 BOLL -0.51 -6.52 -0.34 2.61e-10 Ulcerative colitis; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg13047869 chr3:10149882 C3orf24 0.6 8.36 0.42 1.77e-15 Alzheimer's disease; LUSC cis rs7582720 0.945 rs114604411 chr2:203811912 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs61931739 0.533 rs4270002 chr12:34313126 G/T cg06521331 chr12:34319734 NA -0.4 -6.91 -0.35 2.47e-11 Morning vs. evening chronotype; LUSC cis rs1215050 0.765 rs1588018 chr4:98756324 G/C cg05340658 chr4:99064831 C4orf37 0.43 6.87 0.35 3.2e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1322512 0.713 rs1405693 chr6:152937189 T/C cg27316956 chr6:152958899 SYNE1 -0.36 -5.94 -0.31 7.06e-9 Tonometry; LUSC cis rs4776059 0.798 rs2414160 chr15:52872530 G/C cg22715398 chr15:52968154 KIAA1370 0.63 7.74 0.39 1.18e-13 Schizophrenia; LUSC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg15839431 chr19:19639596 YJEFN3 -0.42 -5.95 -0.31 6.75e-9 Tonsillectomy; LUSC cis rs35146811 0.555 rs1981549 chr7:99541636 A/G cg22906224 chr7:99728672 NA 0.42 5.68 0.3 2.88e-8 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21183028 chr2:37384229 EIF2AK2 0.5 6.9 0.35 2.63e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.79 0.3 1.59e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4285028 0.948 rs12488851 chr3:121687192 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.59 -0.46 2.19e-19 Multiple sclerosis; LUSC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.2 -0.37 3.9e-12 Bipolar disorder; LUSC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.65e-12 Coronary artery disease; LUSC cis rs11630290 0.589 rs2414845 chr15:64167954 T/C cg12036633 chr15:63758958 NA 0.47 5.78 0.3 1.71e-8 Iris characteristics; LUSC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 7.89e-25 Mean corpuscular volume; LUSC trans rs634534 0.562 rs1151505 chr11:65734539 C/T cg17712092 chr4:129076599 LARP1B 0.74 11.3 0.53 2.67e-25 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs1538970 0.816 rs4633317 chr1:45985157 T/C cg06784218 chr1:46089804 CCDC17 0.35 5.99 0.31 5.39e-9 Platelet count; LUSC cis rs9473147 0.516 rs6904764 chr6:47503497 A/T cg20196966 chr6:47445060 CD2AP 0.41 5.64 0.3 3.58e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg05585544 chr11:47624801 NA -0.42 -7.36 -0.37 1.45e-12 Subjective well-being; LUSC trans rs941408 1.000 rs1736180 chr19:2796021 C/T cg19676328 chr12:49525230 TUBA1B -0.51 -8.16 -0.41 6.98e-15 Total cholesterol levels; LUSC cis rs9399135 1.000 rs35123050 chr6:135302740 G/A cg24558204 chr6:135376177 HBS1L 0.58 8.7 0.43 1.51e-16 Red blood cell count; LUSC cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg01579765 chr21:45077557 HSF2BP -0.56 -12.12 -0.55 2.86e-28 Mean corpuscular volume; LUSC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC trans rs17039065 1.000 rs11736209 chr4:109394658 A/T cg07444054 chr2:108107501 NA 0.41 6.11 0.32 2.74e-9 Gut microbiome composition (summer); LUSC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg05368731 chr17:41323189 NBR1 0.93 16.07 0.66 1.86e-43 Menopause (age at onset); LUSC cis rs4132509 0.592 rs12076373 chr1:243851947 G/C cg21452805 chr1:244014465 NA 0.6 6.62 0.34 1.4e-10 RR interval (heart rate); LUSC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.89e-12 Blood metabolite levels; LUSC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg09359103 chr1:154839909 KCNN3 -0.71 -16.2 -0.66 6.03e-44 Prostate cancer; LUSC trans rs877282 0.853 rs11596346 chr10:756673 A/T cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg00334542 chr7:100209784 MOSPD3 -0.65 -7.55 -0.38 4.28e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11229555 0.645 rs10466679 chr11:58188257 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs853679 0.824 rs34712084 chr6:28043828 A/G cg06606381 chr12:133084897 FBRSL1 -0.69 -7.55 -0.38 4.06e-13 Depression; LUSC cis rs1524927 0.966 rs1524920 chr7:96362894 C/T cg03808172 chr7:96339361 SHFM1 -0.4 -6.1 -0.32 2.89e-9 Total body bone mineral density; LUSC cis rs3820928 0.874 rs7563644 chr2:227846932 A/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.6 -0.38 3.07e-13 Pulmonary function; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg19912559 chr1:40204330 PPIE 0.53 8.18 0.41 6.17e-15 Blood protein levels; LUSC cis rs3126085 0.877 rs12116736 chr1:152167062 C/T cg26876637 chr1:152193138 HRNR 0.47 6.6 0.34 1.66e-10 Atopic dermatitis; LUSC trans rs10506458 0.915 rs17687426 chr12:63397900 G/C cg22491629 chr6:157744540 C6orf35 -0.92 -10.95 -0.51 4.68e-24 Hemostatic factors and hematological phenotypes; LUSC trans rs10506458 0.915 rs12426017 chr12:63396272 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -15.44 -0.65 5.73e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs2806561 0.704 rs588387 chr1:23523689 A/G cg12483005 chr1:23474871 LUZP1 0.45 6.92 0.35 2.28e-11 Height; LUSC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg24692254 chr21:30365293 RNF160 -0.82 -15.1 -0.64 1.19e-39 Dental caries; LUSC cis rs7937682 0.824 rs11213962 chr11:111506027 G/A cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg22823121 chr1:150693482 HORMAD1 0.57 8.85 0.44 5.33e-17 Tonsillectomy; LUSC cis rs6121246 0.609 rs6060955 chr20:30385071 A/G cg13852791 chr20:30311386 BCL2L1 0.93 14.3 0.62 1.67e-36 Mean corpuscular hemoglobin; LUSC cis rs2067615 0.524 rs10778504 chr12:107120424 C/T cg19260189 chr12:106995001 RFX4 0.23 5.69 0.3 2.85e-8 Heart rate; LUSC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg12463550 chr7:65579703 CRCP -0.45 -6.65 -0.34 1.23e-10 Aortic root size; LUSC cis rs7119 0.717 rs12916973 chr15:77808099 C/T cg27398640 chr15:77910606 LINGO1 0.3 6.5 0.34 2.96e-10 Type 2 diabetes; LUSC trans rs7829975 0.606 rs11776838 chr8:8794801 C/T cg21775007 chr8:11205619 TDH -0.42 -6.53 -0.34 2.48e-10 Mood instability; LUSC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg16049864 chr8:95962084 TP53INP1 -0.43 -7.18 -0.37 4.7e-12 Type 2 diabetes; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.58 0.67 1.84e-45 Platelet count; LUSC trans rs62103177 0.525 rs612913 chr18:77845882 A/G cg05926928 chr17:57297772 GDPD1 -0.9 -10.32 -0.49 7.2e-22 Opioid sensitivity; LUSC cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg13319975 chr6:146136371 FBXO30 0.43 6.61 0.34 1.53e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7712401 0.541 rs42537 chr5:122274688 A/G cg19077854 chr5:122220652 SNX24 0.42 9.32 0.45 1.68e-18 Mean platelet volume; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02018176 chr4:1364513 KIAA1530 0.72 13.64 0.6 5.68e-34 Longevity; LUSC cis rs449303 1 rs449303 chr14:60605788 A/G cg00846580 chr14:60632234 DHRS7 0.63 6.93 0.35 2.15e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2486288 0.656 rs62026703 chr15:45569929 G/T cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.7 -0.39 1.6e-13 Glomerular filtration rate; LUSC cis rs2580764 0.565 rs7562292 chr2:55230219 C/T cg09592903 chr2:55203963 RTN4 -0.49 -10.1 -0.48 4.03e-21 Mean platelet volume; LUSC cis rs10754283 0.934 rs6661282 chr1:90119992 C/T cg21401794 chr1:90099060 LRRC8C 0.62 8.82 0.43 6.46e-17 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg03929089 chr4:120376271 NA -1.04 -19.98 -0.74 5.38e-59 Height; LUSC cis rs6546550 0.835 rs3755389 chr2:70119469 T/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.17e-12 Prevalent atrial fibrillation; LUSC cis rs9911578 0.813 rs8066773 chr17:56601552 A/G cg12560992 chr17:57184187 TRIM37 0.74 12.23 0.56 1.15e-28 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.13e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs9811920 0.809 rs902159 chr3:99747445 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.43 6.47 0.33 3.5e-10 Axial length; LUSC cis rs11779988 0.545 rs208762 chr8:17806734 G/A cg01800426 chr8:17659068 MTUS1 -0.47 -5.91 -0.31 8.27e-9 Breast cancer; LUSC trans rs7980799 0.682 rs1384599 chr12:33624579 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.4 -0.33 5.18e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg05064044 chr6:292385 DUSP22 0.49 7.35 0.37 1.58e-12 Menopause (age at onset); LUSC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.44 0.33 4.07e-10 Menopause (age at onset); LUSC cis rs7188861 0.603 rs2113260 chr16:11455993 C/T cg00044050 chr16:11439710 C16orf75 0.59 9.03 0.44 1.41e-17 HDL cholesterol; LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.75 0.39 1.12e-13 Gut microbiome composition (summer); LUSC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg09367891 chr1:107599246 PRMT6 0.47 7.26 0.37 2.75e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.27 -6.04 -0.31 4.18e-9 Renal function-related traits (BUN); LUSC cis rs8014204 0.566 rs752857 chr14:75130944 C/T cg06637938 chr14:75390232 RPS6KL1 0.5 7.74 0.39 1.21e-13 Caffeine consumption; LUSC cis rs3892630 0.588 rs28787932 chr19:33226229 T/C cg22980127 chr19:33182716 NUDT19 0.9 12.96 0.58 2.15e-31 Red blood cell traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12662162 chr6:34664887 C6orf106 0.42 6.11 0.32 2.7e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs4332037 1.000 rs4332037 chr7:1950809 C/T cg10840412 chr1:235813424 GNG4 0.65 8.73 0.43 1.21e-16 Bipolar disorder; LUSC cis rs1783925 1.000 rs1783925 chr11:125304009 C/T cg03464685 chr11:125439445 EI24 0.45 6.05 0.31 3.95e-9 Formal thought disorder in schizophrenia; LUSC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg02569458 chr12:86230093 RASSF9 0.61 10.31 0.49 8.24e-22 Major depressive disorder; LUSC cis rs1298062 0.605 rs12327751 chr19:50968890 G/T cg17071417 chr19:50962282 MYBPC2 0.34 5.7 0.3 2.67e-8 Age of smoking initiation; LUSC cis rs9322817 0.691 rs9391241 chr6:105223663 T/C cg02098413 chr6:105308735 HACE1 -0.28 -5.71 -0.3 2.51e-8 Thyroid stimulating hormone; LUSC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs16910800 0.953 rs73481416 chr11:23204663 T/A cg20040320 chr11:23191996 NA -0.44 -6.46 -0.33 3.8e-10 Cancer; LUSC trans rs561341 0.941 rs2428341 chr17:30317295 C/T cg27661571 chr11:113659931 NA -0.55 -6.73 -0.35 7.54e-11 Hip circumference adjusted for BMI; LUSC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg20503657 chr10:835505 NA -0.82 -11.25 -0.52 4.12e-25 Eosinophil percentage of granulocytes; LUSC cis rs10782582 0.609 rs1001160 chr1:76358591 A/C cg03433033 chr1:76189801 ACADM -0.38 -5.84 -0.3 1.21e-8 Daytime sleep phenotypes; LUSC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg07701084 chr6:150067640 NUP43 0.58 9.03 0.44 1.36e-17 Lung cancer; LUSC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg19729930 chr2:74357872 NA 0.89 16.91 0.68 9.05e-47 Gestational age at birth (maternal effect); LUSC cis rs2067615 0.560 rs12298717 chr12:107099883 C/T cg15890332 chr12:107067104 RFX4 -0.34 -6.16 -0.32 2.15e-9 Heart rate; LUSC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg24250549 chr1:154909240 PMVK 0.62 10.15 0.49 2.76e-21 Prostate cancer; LUSC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.58 -0.38 3.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.33 0.37 1.74e-12 Motion sickness; LUSC trans rs9291683 0.552 rs10939656 chr4:10014646 A/C cg26043149 chr18:55253948 FECH 0.51 7.66 0.39 2.01e-13 Bone mineral density; LUSC cis rs16910800 0.954 rs7123141 chr11:23203403 G/A cg20040320 chr11:23191996 NA -0.44 -6.46 -0.33 3.8e-10 Cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08018789 chr16:90039187 AFG3L1;CENPBD1 -0.43 -6.34 -0.33 7.35e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.42 -6.47 -0.33 3.59e-10 Platelet count; LUSC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg16049864 chr8:95962084 TP53INP1 -0.64 -12.4 -0.56 2.6e-29 Type 2 diabetes; LUSC cis rs2249625 0.545 rs9791273 chr6:72891016 G/T cg18830697 chr6:72922368 RIMS1 0.37 7.38 0.37 1.3e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC trans rs10946292 0.656 rs6456170 chr6:170439920 G/C cg17832364 chr10:94847294 NA 0.38 6.28 0.32 1.06e-9 Obesity-related traits; LUSC cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg26446133 chr18:72167187 CNDP2 -0.8 -9.81 -0.47 3.97e-20 Refractive error; LUSC cis rs11583043 0.957 rs6667932 chr1:101503755 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 6.01 0.31 4.78e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg15017067 chr4:17643749 FAM184B 0.34 5.66 0.3 3.25e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9911578 0.757 rs4793954 chr17:56629527 G/T cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -5.85 -0.31 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs7539542 0.556 rs6686801 chr1:202874730 C/T cg19681188 chr1:202830198 LOC148709 0.39 5.75 0.3 1.99e-8 Mean platelet volume; LUSC cis rs4363385 0.818 rs3181787 chr1:153004809 T/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.44e-12 Inflammatory skin disease; LUSC cis rs78579285 0.510 rs78759106 chr16:88788535 T/C cg01900006 chr16:88814613 FAM38A 0.54 6.13 0.32 2.49e-9 Joint mobility (Beighton score); LUSC cis rs73200209 0.744 rs56350518 chr12:116556775 A/G cg01776926 chr12:116560359 MED13L -0.5 -5.99 -0.31 5.44e-9 Total body bone mineral density; LUSC cis rs11166629 1.000 rs2873014 chr8:135645860 C/T cg21672855 chr8:135614777 ZFAT -0.36 -5.74 -0.3 2.13e-8 Smoking quantity; LUSC cis rs2290159 0.800 rs5746191 chr3:12658774 G/A cg23032965 chr3:12705835 RAF1 0.74 8.94 0.44 2.75e-17 Cholesterol, total; LUSC cis rs7177699 0.557 rs10083696 chr15:79124016 G/A cg00540400 chr15:79124168 NA -0.47 -8.15 -0.41 7.33e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs1459104 0.925 rs35473011 chr11:54881353 G/A cg15704280 chr7:45808275 SEPT13 0.71 6.34 0.33 7.62e-10 Body mass index; LUSC cis rs72772090 0.634 rs12186366 chr5:96088850 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.74 -8.36 -0.42 1.74e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.41 6.2 0.32 1.63e-9 Colorectal cancer; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg14893161 chr1:205819251 PM20D1 0.94 18.91 0.72 9.99e-55 Menarche (age at onset); LUSC cis rs7178572 0.633 rs4886875 chr15:77838419 C/T cg22256960 chr15:77711686 NA 0.47 7.06 0.36 9.54e-12 Type 2 diabetes; LUSC cis rs2840044 1.000 rs11656138 chr17:33910218 T/C cg05299278 chr17:33885742 SLFN14 -0.3 -6.31 -0.33 8.91e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg09455208 chr3:40491958 NA 0.57 9.97 0.48 1.15e-20 Renal cell carcinoma; LUSC cis rs8177253 0.696 rs4459901 chr3:133465699 T/C cg01448562 chr3:133502909 NA -0.54 -8.06 -0.4 1.34e-14 Iron status biomarkers; LUSC cis rs8092503 1.000 rs3764513 chr18:52495089 A/G cg12377874 chr18:52495404 RAB27B 0.34 6.01 0.31 4.91e-9 Childhood body mass index; LUSC cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg14993813 chr1:46806288 NSUN4 0.49 6.81 0.35 4.49e-11 Menopause (age at onset); LUSC cis rs2046867 0.661 rs9861834 chr3:72909272 C/T cg25664220 chr3:72788482 NA -0.47 -7.75 -0.39 1.08e-13 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12928939 0.815 rs8049163 chr16:71719353 C/T cg08717414 chr16:71523259 ZNF19 -0.41 -5.76 -0.3 1.96e-8 Post bronchodilator FEV1; LUSC cis rs4642101 0.640 rs12629398 chr3:12826799 A/G cg24848339 chr3:12840334 CAND2 0.35 7.54 0.38 4.52e-13 QRS complex (12-leadsum); LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg15147215 chr3:52552868 STAB1 -0.32 -6.21 -0.32 1.56e-9 Bipolar disorder; LUSC cis rs7572644 0.713 rs4233718 chr2:28066360 A/G cg27432699 chr2:27873401 GPN1 0.52 6.62 0.34 1.45e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs113835537 0.559 rs74933537 chr11:66274958 A/C cg24851651 chr11:66362959 CCS 0.53 7.92 0.4 3.47e-14 Airway imaging phenotypes; LUSC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg08219700 chr8:58056026 NA 0.65 7.22 0.37 3.52e-12 Developmental language disorder (linguistic errors); LUSC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg09085632 chr11:111637200 PPP2R1B -1.03 -16.29 -0.67 2.44e-44 Primary sclerosing cholangitis; LUSC cis rs12438659 1 rs12438659 chr15:78824924 G/A cg18825076 chr15:78729989 IREB2 0.46 6.12 0.32 2.65e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9858542 0.537 rs2304442 chr3:49322027 A/T cg03060546 chr3:49711283 APEH 0.55 6.72 0.35 7.87e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs12594515 0.935 rs8042519 chr15:45996341 G/C cg01629716 chr15:45996671 NA 0.4 5.93 0.31 7.63e-9 Waist circumference;Weight; LUSC cis rs9687065 1.000 rs6885467 chr5:148379555 C/G cg23229984 chr5:148520753 ABLIM3 -0.45 -6.91 -0.35 2.42e-11 Diastolic blood pressure; LUSC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg09034736 chr1:150693464 HORMAD1 -0.44 -6.22 -0.32 1.53e-9 Melanoma; LUSC cis rs7824557 0.806 rs10503418 chr8:11118983 C/T cg21775007 chr8:11205619 TDH -0.59 -9.28 -0.45 2.18e-18 Retinal vascular caliber; LUSC cis rs10499694 0.868 rs1470749 chr7:50578023 G/T cg18232548 chr7:50535776 DDC -0.4 -5.88 -0.31 1.02e-8 Body mass index; LUSC trans rs11250098 0.548 rs7837038 chr8:10783074 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -7.35 -0.37 1.56e-12 Morning vs. evening chronotype; LUSC cis rs317689 0.581 rs315132 chr12:69761996 G/C cg14784868 chr12:69753453 YEATS4 0.63 8.92 0.44 3.09e-17 Response to diuretic therapy; LUSC cis rs7173743 0.967 rs28580532 chr15:79134724 C/T cg00540400 chr15:79124168 NA -0.33 -5.67 -0.3 3.08e-8 Coronary artery disease; LUSC cis rs10492096 0.945 rs1045546 chr12:6567907 C/T cg13857086 chr12:6580257 VAMP1 0.82 9.17 0.45 4.96e-18 Hip geometry; LUSC cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -6.99 -0.36 1.49e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg25703541 chr22:24373054 LOC391322 -0.87 -14.94 -0.63 5.19e-39 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11048434 0.736 rs12812913 chr12:9110836 C/G cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg05535760 chr7:792225 HEATR2 0.79 9.26 0.45 2.63e-18 Cerebrospinal P-tau181p levels; LUSC cis rs6456156 0.565 rs12529959 chr6:167469292 T/C cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs17253792 0.822 rs74940664 chr14:56135065 A/G cg01858014 chr14:56050164 KTN1 -0.77 -6.57 -0.34 1.95e-10 Putamen volume; LUSC cis rs1153858 1.000 rs2467863 chr15:45641880 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.0 0.4 2.01e-14 Homoarginine levels; LUSC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg09034736 chr1:150693464 HORMAD1 0.41 5.75 0.3 2.04e-8 Melanoma; LUSC cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.67 -0.5 4.64e-23 Alzheimer's disease (late onset); LUSC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg02423579 chr7:2872169 GNA12 -0.5 -7.18 -0.37 4.56e-12 Height; LUSC cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC trans rs1908814 0.516 rs10113145 chr8:11793295 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.2e-15 Neuroticism; LUSC cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.55 -8.01 -0.4 1.91e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11644478 chr21:40555479 PSMG1 -0.94 -18.88 -0.72 1.24e-54 Cognitive function; LUSC trans rs2268344 0.562 rs909290 chr10:124264032 A/G cg11199862 chr13:46108984 COG3 -0.67 -5.99 -0.31 5.3300000000000004e-09 Coronary artery disease; LUSC cis rs60695258 0.550 rs6531948 chr4:87972968 T/C cg10685359 chr4:87814065 C4orf36 -0.35 -6.24 -0.32 1.3e-9 Hematocrit; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg18876405 chr7:65276391 NA -0.52 -8.24 -0.41 3.85e-15 Calcium levels; LUSC cis rs2250402 0.510 rs6492926 chr15:40325829 T/G cg20059928 chr15:40361485 NA -0.51 -6.05 -0.31 3.94e-9 Corneal curvature; LUSC cis rs17255340 0.539 rs1170342 chr6:84034415 T/G cg08257003 chr6:84140564 ME1 0.34 8.19 0.41 5.61e-15 Platelet-derived growth factor BB levels; LUSC trans rs2797160 1.000 rs13328298 chr6:126016580 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.85 0.35 3.56e-11 Endometrial cancer; LUSC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs637571 0.522 rs606978 chr11:65711517 A/C cg26695010 chr11:65641043 EFEMP2 -0.47 -6.91 -0.35 2.39e-11 Eosinophil percentage of white cells; LUSC cis rs3741151 0.687 rs56857598 chr11:73234173 G/A cg17517138 chr11:73019481 ARHGEF17 0.96 8.06 0.4 1.35e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs28735056 1.000 rs56376220 chr18:77609462 C/T cg05926928 chr17:57297772 GDPD1 -0.46 -6.53 -0.34 2.38e-10 Schizophrenia; LUSC trans rs877282 0.898 rs35743076 chr10:758991 C/T cg13042288 chr15:90349979 ANPEP -0.44 -6.41 -0.33 4.87e-10 Uric acid levels; LUSC cis rs4474465 0.646 rs4945301 chr11:78283362 A/G cg27205649 chr11:78285834 NARS2 0.56 6.83 0.35 4.11e-11 Alzheimer's disease (survival time); LUSC cis rs34779708 0.966 rs11592567 chr10:35409369 C/T cg03585969 chr10:35415529 CREM 0.62 8.97 0.44 2.2e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1448094 0.737 rs10863135 chr12:86382657 C/T cg18827107 chr12:86230957 RASSF9 -0.38 -5.67 -0.3 3.15e-8 Major depressive disorder; LUSC cis rs7605827 0.930 rs2160691 chr2:15598197 G/A cg19274914 chr2:15703543 NA 0.46 8.9 0.44 3.54e-17 Educational attainment (years of education); LUSC cis rs1775715 0.707 rs2065443 chr10:32164236 C/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.84 0.39 6.07e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4356932 0.967 rs28681694 chr4:76972594 A/C cg00809888 chr4:76862425 NAAA 0.35 5.85 0.3 1.2e-8 Blood protein levels; LUSC cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg11244672 chr19:19639970 YJEFN3 0.61 7.59 0.38 3.3e-13 Bipolar disorder; LUSC trans rs4588 0.626 rs2091395 chr4:72596468 G/A cg14203426 chr7:101723947 CUX1 -0.39 -5.95 -0.31 6.84e-9 Vitamin D levels; LUSC cis rs7246967 0.673 rs7253063 chr19:22865897 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs9309473 1.000 rs7607014 chr2:73730174 C/T cg20560298 chr2:73613845 ALMS1 0.42 6.1 0.32 3e-9 Metabolite levels; LUSC cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.79 0.35 5.25e-11 Lung cancer in ever smokers; LUSC cis rs12618769 0.597 rs17031139 chr2:99036530 A/G cg10123293 chr2:99228465 UNC50 -0.47 -8.01 -0.4 1.93e-14 Bipolar disorder; LUSC cis rs6121246 0.909 rs6088962 chr20:30268184 C/T cg13852791 chr20:30311386 BCL2L1 0.95 12.18 0.55 1.74e-28 Mean corpuscular hemoglobin; LUSC cis rs2734839 0.927 rs2734837 chr11:113286829 C/T cg14159747 chr11:113255604 NA 0.26 6.56 0.34 2.1e-10 Information processing speed; LUSC cis rs10887741 0.646 rs10218939 chr10:89436853 A/G cg13926569 chr10:89418898 PAPSS2 0.32 6.92 0.35 2.27e-11 Exercise (leisure time); LUSC trans rs6076960 0.629 rs6054024 chr20:6229282 A/C cg21095983 chr6:86352623 SYNCRIP 0.5 7.74 0.39 1.19e-13 Smooth-surface caries; LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs73206853 0.563 rs73194046 chr12:111191665 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 6.91 0.35 2.49e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg13628971 chr7:2884303 GNA12 0.48 6.69 0.34 9.35e-11 Height; LUSC cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 13.58 0.6 9.2e-34 Chronic sinus infection; LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs4499344 0.633 rs259258 chr19:33152523 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.42 0.53 1.02e-25 Mean platelet volume; LUSC cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg00530320 chr1:46809349 NSUN4 0.56 8.72 0.43 1.29e-16 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03698702 chr19:36236336 PSENEN;U2AF1L4 0.43 6.55 0.34 2.17e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9302065 0.681 rs9524903 chr13:95963565 A/G cg24476569 chr13:95954382 ABCC4 -0.5 -7.94 -0.4 3.11e-14 Blood metabolite levels; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.75e-17 Prudent dietary pattern; LUSC cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.35 -0.37 1.56e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs75920871 0.528 rs11600552 chr11:116900947 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.42 -0.33 4.68e-10 Subjective well-being; LUSC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg27432699 chr2:27873401 GPN1 -0.56 -8.31 -0.41 2.49e-15 Total body bone mineral density; LUSC cis rs981844 0.826 rs4585278 chr4:154684145 A/G cg14289246 chr4:154710475 SFRP2 0.5 6.71 0.34 8.26e-11 Response to statins (LDL cholesterol change); LUSC cis rs12900413 0.603 rs4448912 chr15:90299690 G/A cg24249390 chr15:90295951 MESP1 -0.37 -5.91 -0.31 8.58e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs11167764 0.638 rs7729747 chr5:141478055 C/A cg08523384 chr5:141488047 NDFIP1 -0.51 -6.86 -0.35 3.42e-11 Crohn's disease; LUSC trans rs4689592 0.619 rs2359011 chr4:7066052 T/G cg07817883 chr1:32538562 TMEM39B -0.61 -7.39 -0.37 1.17e-12 Monocyte percentage of white cells; LUSC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg13206674 chr6:150067644 NUP43 0.58 9.05 0.44 1.19e-17 Lung cancer; LUSC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg13736514 chr6:26305472 NA -0.47 -9.43 -0.46 7.21e-19 Educational attainment; LUSC cis rs4588572 0.644 rs6873144 chr5:77741784 C/T cg11547950 chr5:77652471 NA -0.46 -6.74 -0.35 7.08e-11 Triglycerides; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg22166914 chr1:53195759 ZYG11B -0.62 -10.21 -0.49 1.73e-21 Monocyte count; LUSC cis rs730566 1.000 rs4858819 chr3:48478088 C/T cg21141812 chr3:48556323 PFKFB4 -0.32 -6.48 -0.33 3.25e-10 Prion diseases; LUSC cis rs2637266 1.000 rs6480824 chr10:78355705 G/A cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs9302690 0.557 rs223875 chr16:57506915 C/T cg16753122 chr16:57506917 DOK4 0.56 6.98 0.36 1.55e-11 Blood protein levels; LUSC cis rs11030122 0.702 rs995498 chr11:3967791 A/G cg08557956 chr11:4115526 RRM1 -0.45 -5.69 -0.3 2.74e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.58 -0.57 5.63e-30 Alzheimer's disease; LUSC cis rs11048434 0.736 rs4309200 chr12:9121856 A/C cg04155231 chr12:9217510 LOC144571 0.31 5.69 0.3 2.82e-8 Sjögren's syndrome; LUSC cis rs4974559 0.947 rs10000012 chr4:1357325 C/G cg02980000 chr4:1222292 CTBP1 -0.68 -7.07 -0.36 9.03e-12 Systolic blood pressure; LUSC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg11845111 chr2:191398756 TMEM194B 0.57 9.65 0.47 1.36e-19 Pulse pressure; LUSC cis rs6696846 0.765 rs61822565 chr1:205077332 T/C cg21545522 chr1:205238299 TMCC2 0.46 8.63 0.43 2.61e-16 Red blood cell count; LUSC cis rs9611565 0.879 rs5758311 chr22:41759375 G/T cg03806693 chr22:41940476 POLR3H -0.78 -11.17 -0.52 7.84e-25 Vitiligo; LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.81 -0.35 4.6e-11 Menopause (age at onset); LUSC trans rs3857536 0.611 rs6927407 chr6:66870010 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.5 -7.15 -0.36 5.39e-12 Blood trace element (Cu levels); LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02475777 chr4:1388615 CRIPAK 0.56 8.67 0.43 1.9e-16 Longevity; LUSC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg02423579 chr7:2872169 GNA12 -0.43 -6.1 -0.32 2.95e-9 Height; LUSC cis rs9326248 0.520 rs10892060 chr11:116881662 C/A cg11861562 chr11:117069780 TAGLN 0.31 6.09 0.32 3.08e-9 Blood protein levels; LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg07507251 chr3:52567010 NT5DC2 0.32 6.3 0.33 9.19e-10 Bipolar disorder; LUSC cis rs478304 0.593 rs4645927 chr11:65482827 C/T cg27068330 chr11:65405492 SIPA1 -0.75 -10.45 -0.5 2.65e-22 Acne (severe); LUSC cis rs10782582 0.593 rs11163904 chr1:76121208 A/G cg10523679 chr1:76189770 ACADM 0.48 7.14 0.36 5.75e-12 Daytime sleep phenotypes; LUSC cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg03146154 chr1:46216737 IPP 0.56 8.36 0.42 1.77e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12190007 0.508 rs9406321 chr6:169726841 A/T cg16388071 chr6:169726476 NA 0.44 6.79 0.35 5.29e-11 Obesity-related traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02836487 chr3:128206457 GATA2 0.41 6.18 0.32 1.82e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg22875332 chr1:76189707 ACADM 0.85 13.93 0.61 4.13e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg13072238 chr3:49761600 GMPPB -0.7 -8.8 -0.43 7.28e-17 Menarche (age at onset); LUSC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC trans rs11098499 0.954 rs13145352 chr4:120409963 C/T cg25214090 chr10:38739885 LOC399744 -0.49 -7.33 -0.37 1.77e-12 Corneal astigmatism; LUSC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg05368731 chr17:41323189 NBR1 0.83 14.06 0.61 1.38e-35 Menopause (age at onset); LUSC cis rs7819412 0.521 rs11777887 chr8:11036799 C/G cg21775007 chr8:11205619 TDH 0.47 6.71 0.34 8.33e-11 Triglycerides; LUSC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg04455712 chr21:45112962 RRP1B 0.44 8.29 0.41 2.74e-15 Mean corpuscular volume; LUSC cis rs9399135 0.967 rs6909975 chr6:135315570 C/T cg22676075 chr6:135203613 NA 0.49 7.68 0.39 1.72e-13 Red blood cell count; LUSC cis rs1419980 1.000 rs1419980 chr12:7774892 A/G cg25828445 chr12:7781288 NA -0.76 -7.14 -0.36 5.97e-12 HDL cholesterol levels; LUSC trans rs62103177 0.810 rs62103191 chr18:77628769 C/G cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC cis rs7264396 0.887 rs3818441 chr20:34046501 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.71 -0.34 8.33e-11 Total cholesterol levels; LUSC cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg06462663 chr19:18546047 ISYNA1 0.49 8.25 0.41 3.75e-15 Breast cancer; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg08859206 chr1:53392774 SCP2 0.56 9.9 0.48 1.93e-20 Monocyte count; LUSC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.98 0.58 1.75e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg09796270 chr17:17721594 SREBF1 -0.43 -7.55 -0.38 4.32e-13 Total body bone mineral density; LUSC cis rs10791097 0.547 rs12365680 chr11:130749059 C/T cg12179176 chr11:130786555 SNX19 0.84 14.89 0.63 8.18e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.38 0.33 6.01e-10 Renal cell carcinoma; LUSC cis rs11630290 1.000 rs72750981 chr15:63983737 A/T cg12036633 chr15:63758958 NA -0.73 -8.15 -0.41 7.63e-15 Iris characteristics; LUSC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg15369054 chr17:80825471 TBCD 0.69 11.31 0.53 2.57e-25 Breast cancer; LUSC cis rs1891275 0.515 rs7098763 chr10:93444827 C/T cg07889827 chr10:93443413 NA -0.38 -8.55 -0.42 4.34e-16 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg08270630 chr22:50330655 NA -0.43 -6.42 -0.33 4.8e-10 Schizophrenia; LUSC cis rs11190604 1.000 rs2295770 chr10:102239829 G/A cg07080220 chr10:102295463 HIF1AN 0.63 8.34 0.42 1.94e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs16949788 1.000 rs7183477 chr15:66748212 T/A cg08120210 chr15:66682733 MAP2K1 -0.62 -6.2 -0.32 1.65e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1172822 0.828 rs11668344 chr19:55833664 A/G cg04391588 chr19:55832610 TMEM150B 0.31 5.71 0.3 2.53e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs10779751 0.770 rs1057079 chr1:11205058 A/G cg04508216 chr1:11107452 MASP2 -0.34 -6.08 -0.32 3.2e-9 Body mass index; LUSC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg20503657 chr10:835505 NA 0.99 13.49 0.59 2.17e-33 Eosinophil percentage of granulocytes; LUSC cis rs7072216 0.763 rs7914401 chr10:100163928 A/G cg26618903 chr10:100175079 PYROXD2 -0.44 -8.53 -0.42 5.25e-16 Metabolite levels; LUSC cis rs3741151 1.000 rs75912489 chr11:73073846 G/A cg17517138 chr11:73019481 ARHGEF17 1.11 9.05 0.44 1.23e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg03678062 chr6:149772716 ZC3H12D 0.33 6.8 0.35 4.78e-11 Dupuytren's disease; LUSC cis rs16895831 0.519 rs12196856 chr6:42554187 T/A cg10605015 chr6:42532144 UBR2 -0.49 -5.88 -0.31 1.01e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs9467773 0.550 rs4712987 chr6:26399615 A/C cg09904177 chr6:26538194 HMGN4 -0.55 -8.16 -0.41 6.83e-15 Intelligence (multi-trait analysis); LUSC cis rs9309473 0.615 rs62153183 chr2:73763366 A/G cg20560298 chr2:73613845 ALMS1 -0.57 -6.76 -0.35 6.3e-11 Metabolite levels; LUSC cis rs17253792 0.822 rs10083303 chr14:56068521 T/C cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs11051970 0.918 rs6488050 chr12:32532499 A/T cg02745156 chr12:32552066 NA 0.44 6.98 0.36 1.58e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -9.84 -0.47 3.07e-20 Glomerular filtration rate (creatinine); LUSC cis rs1355223 0.934 rs5010670 chr11:34766649 A/C cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.85 -0.3 1.15e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7572644 0.679 rs17006365 chr2:28123374 T/G cg27432699 chr2:27873401 GPN1 -0.52 -6.95 -0.36 1.91e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11155671 0.530 rs4869763 chr6:150211684 T/C cg07701084 chr6:150067640 NUP43 0.47 6.98 0.36 1.56e-11 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.77e-30 Motion sickness; LUSC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12756686 chr19:29218302 NA 0.68 9.59 0.46 2.11e-19 Methadone dose in opioid dependence; LUSC trans rs2797160 0.651 rs6939969 chr6:126034563 C/T cg05039488 chr6:79577232 IRAK1BP1 0.64 10.19 0.49 2.01e-21 Endometrial cancer; LUSC cis rs477692 0.935 rs554458 chr10:131427372 A/G cg05714579 chr10:131428358 MGMT 0.53 8.08 0.4 1.19e-14 Response to temozolomide; LUSC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg01065977 chr19:18549689 ISYNA1 -0.22 -5.65 -0.3 3.51e-8 Breast cancer; LUSC trans rs3733585 0.699 rs6844787 chr4:9959233 A/G cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03911494 chr16:71660463 MARVELD3 -0.43 -6.61 -0.34 1.51e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg24675658 chr1:53192096 ZYG11B 0.58 9.11 0.45 7.92e-18 Monocyte count; LUSC cis rs2797160 1.000 rs1777194 chr6:126004883 G/A cg05901451 chr6:126070800 HEY2 -0.57 -8.56 -0.42 4.29e-16 Endometrial cancer; LUSC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg08470875 chr2:26401718 FAM59B -0.7 -9.1 -0.45 8.49e-18 Gut microbiome composition (summer); LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg11399754 chr5:64920452 C5orf44;TRIM23 0.39 6.08 0.32 3.29e-9 Major depressive disorder; LUSC cis rs1577917 1.000 rs12215903 chr6:86675028 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.39 -0.42 1.41e-15 Response to antipsychotic treatment; LUSC cis rs2361718 0.631 rs4889989 chr17:78151860 C/G cg09238746 chr17:78121135 EIF4A3 0.72 10.73 0.51 2.88e-23 Yeast infection; LUSC cis rs4654899 0.743 rs61781069 chr1:21130735 T/C cg01072550 chr1:21505969 NA -0.52 -7.6 -0.38 2.97e-13 Superior frontal gyrus grey matter volume; LUSC cis rs34172651 0.917 rs11646987 chr16:24832408 G/T cg00339695 chr16:24857497 SLC5A11 0.37 6.5 0.34 2.96e-10 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg04234412 chr22:24373322 LOC391322 0.84 13.65 0.6 4.98e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg15549821 chr19:49342101 PLEKHA4 -0.52 -6.09 -0.32 3.13e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg08798685 chr6:27730294 NA -0.48 -5.92 -0.31 7.91e-9 Breast cancer; LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg00149659 chr3:10157352 C3orf10 0.9 11.91 0.55 1.63e-27 Alzheimer's disease; LUSC cis rs1322512 0.876 rs1744372 chr6:152944926 C/G cg27316956 chr6:152958899 SYNE1 -0.33 -5.66 -0.3 3.25e-8 Tonometry; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11380545 chr4:83351682 ENOPH1;HNRPDL -0.43 -6.39 -0.33 5.5e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1535500 1.000 rs3734618 chr6:39284184 A/G cg03252829 chr6:39282164 KCNK17 -0.32 -5.67 -0.3 3.1e-8 Type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04031383 chr16:84088007 MBTPS1 -0.73 -6.07 -0.32 3.48e-9 Cognitive performance; LUSC cis rs7177699 0.534 rs7403708 chr15:79123885 T/C cg15571903 chr15:79123663 NA -0.36 -6.58 -0.34 1.8e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg12935359 chr14:103987150 CKB -0.54 -9.01 -0.44 1.62e-17 Intelligence (multi-trait analysis); LUSC trans rs7824557 0.583 rs4448232 chr8:11231354 G/T cg06636001 chr8:8085503 FLJ10661 0.56 8.34 0.42 1.98e-15 Retinal vascular caliber; LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg07677032 chr17:61819896 STRADA 0.53 8.93 0.44 2.87e-17 Prudent dietary pattern; LUSC cis rs62458065 0.850 rs62458066 chr7:32464484 C/T cg20159608 chr7:32802032 NA -0.69 -8.19 -0.41 5.6e-15 Metabolite levels (HVA/MHPG ratio); LUSC trans rs10486158 0.689 rs2052137 chr7:7385180 C/T cg01895333 chr3:109035405 DPPA2 -0.38 -6.02 -0.31 4.65e-9 Bipolar disorder and schizophrenia; LUSC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg00745463 chr17:30367425 LRRC37B -0.7 -8.63 -0.43 2.59e-16 Hip circumference adjusted for BMI; LUSC cis rs10992471 0.756 rs10115222 chr9:95128149 C/T cg14631576 chr9:95140430 CENPP 0.33 5.88 0.31 9.97e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs208520 1.000 rs9453663 chr6:66976077 A/G cg07460842 chr6:66804631 NA 0.94 12.35 0.56 4.02e-29 Exhaled nitric oxide output; LUSC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg15017067 chr4:17643749 FAM184B -0.35 -5.72 -0.3 2.34e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6840360 0.607 rs1561918 chr4:152446832 T/A cg20465933 chr4:152376761 FAM160A1 0.33 5.97 0.31 6.02e-9 Intelligence (multi-trait analysis); LUSC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg06713675 chr4:122721982 EXOSC9 -0.68 -11.89 -0.55 2.03e-27 Type 2 diabetes; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.84 0.3 1.22e-8 Menopause (age at onset); LUSC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg03264133 chr6:25882463 NA -0.46 -7.64 -0.39 2.34e-13 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.89 0.61 5.9e-35 Platelet count; LUSC cis rs362272 0.525 rs910568 chr4:3307373 A/G cg00810483 chr4:3375144 RGS12 0.3 5.66 0.3 3.19e-8 Serum sulfate level; LUSC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg18827107 chr12:86230957 RASSF9 -0.41 -5.93 -0.31 7.42e-9 Major depressive disorder; LUSC cis rs9653442 0.712 rs6714788 chr2:100686173 A/G cg22139774 chr2:100720529 AFF3 0.48 8.39 0.42 1.42e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7607369 0.559 rs13027908 chr2:219660374 T/C cg02176678 chr2:219576539 TTLL4 -0.54 -9.62 -0.47 1.72e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs1973993 0.691 rs4000303 chr1:96913765 A/G cg10631902 chr5:14652156 NA 0.61 11.01 0.52 2.95e-24 Weight; LUSC cis rs4889855 0.556 rs74003969 chr17:78526212 C/T cg16591659 chr17:78472290 NA 0.33 5.83 0.3 1.34e-8 Fractional excretion of uric acid; LUSC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg06618935 chr21:46677482 NA -0.41 -8.04 -0.4 1.58e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs5769765 0.542 rs5770720 chr22:50253101 A/G cg02269571 chr22:50332266 NA 0.58 7.48 0.38 6.75e-13 Schizophrenia; LUSC trans rs6480314 0.542 rs61854813 chr10:70027221 G/T cg04882175 chr6:131122610 NA -0.55 -6.39 -0.33 5.64e-10 Optic nerve measurement (disc area); LUSC trans rs7939886 0.920 rs11227507 chr11:55972274 G/A cg03929089 chr4:120376271 NA 0.83 6.2 0.32 1.71e-9 Myopia (pathological); LUSC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg04369109 chr6:150039330 LATS1 -0.58 -8.57 -0.42 4e-16 Lung cancer; LUSC cis rs8072100 0.790 rs11656856 chr17:45714671 C/T cg08085267 chr17:45401833 C17orf57 0.47 6.92 0.35 2.37e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2236521 0.617 rs2236520 chr20:60892172 T/C cg09594475 chr20:60884601 LAMA5 0.46 6.93 0.35 2.12e-11 Pelvic organ prolapse; LUSC cis rs34779708 0.931 rs11010125 chr10:35502953 A/G cg04310649 chr10:35416472 CREM -0.41 -6.32 -0.33 8.17e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg17724175 chr1:150552817 MCL1 -0.37 -6.72 -0.35 7.92e-11 Tonsillectomy; LUSC cis rs9359856 0.518 rs10944451 chr6:90262341 A/G cg13799429 chr6:90582589 CASP8AP2 -0.57 -6.07 -0.32 3.45e-9 Bipolar disorder; LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC trans rs75763843 1.000 rs12456660 chr18:42101049 C/T cg12620806 chr12:5602045 NTF3 -0.53 -6.01 -0.31 4.8e-9 Mean platelet volume; LUSC cis rs240764 0.658 rs9404053 chr6:101254456 G/A cg09795085 chr6:101329169 ASCC3 -0.46 -6.56 -0.34 2.01e-10 Neuroticism; LUSC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg07701084 chr6:150067640 NUP43 0.51 7.27 0.37 2.65e-12 Lung cancer; LUSC cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg04851639 chr8:1020857 NA -0.38 -7.78 -0.39 9.14e-14 Schizophrenia; LUSC cis rs7584330 0.554 rs76605518 chr2:238425992 G/A cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC cis rs3820068 0.581 rs6429762 chr1:15945595 A/C cg24675056 chr1:15929824 NA 0.47 8.2 0.41 5.31e-15 Systolic blood pressure; LUSC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg04362960 chr10:104952993 NT5C2 -0.61 -9.11 -0.45 7.55e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs7824557 0.564 rs12547100 chr8:11242632 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -8.4 -0.42 1.34e-15 Retinal vascular caliber; LUSC cis rs354225 0.544 rs10208225 chr2:54806049 G/A cg26097391 chr2:54893211 SPTBN1 0.46 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg25072359 chr17:41440525 NA 0.58 7.51 0.38 5.43e-13 Menopause (age at onset); LUSC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg06618935 chr21:46677482 NA -0.37 -7.41 -0.38 1.02e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11756438 0.572 rs1857312 chr6:119001526 A/C cg18833306 chr6:118973337 C6orf204 0.36 5.76 0.3 1.88e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1185460 0.904 rs1003081 chr11:118913993 A/G cg23280166 chr11:118938394 VPS11 -0.38 -5.66 -0.3 3.23e-8 Coronary artery disease; LUSC cis rs1371867 0.846 rs1660345 chr8:101322762 C/A cg00191853 chr8:101177733 SPAG1 -0.4 -6.39 -0.33 5.48e-10 Atrioventricular conduction; LUSC cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg21535247 chr6:8435926 SLC35B3 0.57 9.02 0.44 1.5e-17 Motion sickness; LUSC cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.31 -0.37 1.94e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.909 rs17046118 chr4:120387496 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.05e-9 Corneal astigmatism; LUSC trans rs1005277 0.577 rs4934906 chr10:38015028 C/T cg17830980 chr10:43048298 ZNF37B -0.41 -6.41 -0.33 4.83e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7647973 0.626 rs11720705 chr3:49753788 A/G cg13072238 chr3:49761600 GMPPB -0.63 -8.04 -0.4 1.57e-14 Menarche (age at onset); LUSC cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg20821713 chr7:1055600 C7orf50 -0.4 -5.66 -0.3 3.2e-8 Bronchopulmonary dysplasia; LUSC cis rs7572644 0.640 rs11901133 chr2:28069713 T/G cg27432699 chr2:27873401 GPN1 0.51 6.96 0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs899997 0.862 rs57260218 chr15:78973772 C/T cg04896959 chr15:78267971 NA -0.46 -9.11 -0.45 7.57e-18 Coronary artery disease or large artery stroke; LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg22166914 chr1:53195759 ZYG11B 0.61 10.25 0.49 1.29e-21 Monocyte count; LUSC cis rs2797160 1.000 rs6934435 chr6:126017481 T/G cg05901451 chr6:126070800 HEY2 0.57 8.61 0.43 2.85e-16 Endometrial cancer; LUSC cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.31 -0.56 5.76e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.564 rs13274106 chr8:11233958 A/G cg21775007 chr8:11205619 TDH -0.67 -10.66 -0.5 5.14e-23 Retinal vascular caliber; LUSC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg06600287 chr1:53387719 ECHDC2 -0.31 -6.42 -0.33 4.8e-10 Monocyte count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19483816 chr5:180670343 GNB2L1;SNORD95;SNORD96A 0.43 6.42 0.33 4.8e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72949976 0.646 rs1441169 chr2:214033530 A/G cg08319019 chr2:214017104 IKZF2 0.63 10.34 0.49 6.58e-22 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg08219700 chr8:58056026 NA 0.49 6.11 0.32 2.75e-9 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs2424716 chr20:25423538 G/A cg08601574 chr20:25228251 PYGB 0.44 6.79 0.35 5.29e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12760731 0.720 rs2862379 chr1:178442906 T/A cg00404053 chr1:178313656 RASAL2 0.59 6.32 0.33 8.28e-10 Obesity-related traits; LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg00945038 chr17:61921165 SMARCD2 0.54 9.36 0.46 1.17e-18 Prudent dietary pattern; LUSC trans rs853679 1.000 rs853676 chr6:28299687 C/T cg01620082 chr3:125678407 NA -0.59 -6.6 -0.34 1.62e-10 Depression; LUSC cis rs4964805 0.770 rs11111779 chr12:104185496 G/A cg02344784 chr12:104178138 NT5DC3 0.43 6.97 0.36 1.7e-11 Attention deficit hyperactivity disorder; LUSC cis rs11148252 0.553 rs7999849 chr13:53249414 A/G cg00495681 chr13:53174319 NA 0.79 15.33 0.64 1.48e-40 Lewy body disease; LUSC cis rs6977660 0.714 rs10232870 chr7:19818040 A/G cg05791153 chr7:19748676 TWISTNB 0.66 7.0 0.36 1.38e-11 Thyroid stimulating hormone; LUSC cis rs929354 0.772 rs6969244 chr7:157004012 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.61 -0.47 1.89e-19 Body mass index; LUSC cis rs9303401 0.659 rs62083368 chr17:56878062 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.34 0.59 7.79e-33 Cognitive test performance; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21369679 chr16:47007757 DNAJA2 0.47 6.53 0.34 2.39e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs921968 0.509 rs626432 chr2:219355658 C/A cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs2303282 0.639 rs11644357 chr16:56445252 G/T cg00500540 chr16:56394104 NA -0.39 -6.72 -0.34 8.01e-11 Breast cancer; LUSC cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg24733560 chr20:60626293 TAF4 0.43 7.82 0.39 6.95e-14 Body mass index; LUSC cis rs2070433 0.539 rs2070432 chr21:47957332 G/A cg12379764 chr21:47803548 PCNT 0.8 11.88 0.55 2.12e-27 Lymphocyte counts; LUSC cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg08999081 chr20:33150536 PIGU -0.54 -10.72 -0.51 2.94e-23 Glomerular filtration rate (creatinine); LUSC cis rs9929218 0.906 rs10852450 chr16:68749529 G/A cg02972257 chr16:68554789 NA 0.45 5.87 0.31 1.06e-8 Colorectal cancer; LUSC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.74 0.3 2.14e-8 Menopause (age at onset); LUSC cis rs7246967 0.611 rs2885222 chr19:22839944 T/G cg23217946 chr19:22817039 ZNF492 0.49 6.87 0.35 3.18e-11 Bronchopulmonary dysplasia; LUSC cis rs9527 0.590 rs12415388 chr10:104796345 T/C cg05855489 chr10:104503620 C10orf26 0.53 8.07 0.4 1.28e-14 Arsenic metabolism; LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg08736216 chr1:53307985 ZYG11A 0.31 6.27 0.32 1.1e-9 Monocyte count; LUSC trans rs1005277 0.579 rs116912400 chr10:38479207 G/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.15 -0.45 5.6e-18 Extrinsic epigenetic age acceleration; LUSC cis rs12220238 0.908 rs10824124 chr10:75997360 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.09 0.36 8.18e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs941898 0.957 rs3783337 chr14:100595278 T/A cg26002632 chr14:100625216 DEGS2 -0.31 -5.66 -0.3 3.22e-8 White matter hyperintensity burden; LUSC cis rs72949976 0.934 rs10197392 chr2:214038178 G/A cg08319019 chr2:214017104 IKZF2 -0.62 -9.4 -0.46 9.07e-19 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg23711669 chr6:146136114 FBXO30 0.82 14.71 0.63 4.15e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.01 -0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC cis rs2274273 0.840 rs28568813 chr14:55794114 C/G cg04306507 chr14:55594613 LGALS3 0.56 12.93 0.58 2.87e-31 Protein biomarker; LUSC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg10523679 chr1:76189770 ACADM 0.87 14.2 0.61 3.99e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs751728 1.000 rs2296747 chr6:33744882 C/G cg25922239 chr6:33757077 LEMD2 0.53 8.0 0.4 2.01e-14 Crohn's disease; LUSC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.27 -0.32 1.13e-9 Neutrophil percentage of white cells; LUSC cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg12292205 chr6:26970375 C6orf41 -0.68 -9.12 -0.45 7.09e-18 Intelligence (multi-trait analysis); LUSC cis rs2463822 1.000 rs2463825 chr11:62094493 G/A cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg06481639 chr22:41940642 POLR3H -0.53 -6.11 -0.32 2.81e-9 Vitiligo; LUSC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.62e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.692 rs7174673 chr15:77071998 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.9 -0.4 4.04e-14 Blood metabolite levels; LUSC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.4e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10751667 0.580 rs7395515 chr11:1005160 C/T ch.11.42038R chr11:967971 AP2A2 0.47 7.07 0.36 8.92e-12 Alzheimer's disease (late onset); LUSC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg15704280 chr7:45808275 SEPT13 -1.11 -24.45 -0.8 2.07e-76 Height; LUSC cis rs7481584 0.624 rs449164 chr11:3053454 C/T cg05729581 chr11:3078854 CARS 0.39 5.74 0.3 2.08e-8 Calcium levels; LUSC cis rs2304069 0.601 rs216143 chr5:149444147 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.56 7.48 0.38 6.69e-13 HIV-1 control; LUSC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg25319279 chr11:5960081 NA 0.41 6.51 0.34 2.71e-10 DNA methylation (variation); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00556719 chr9:108457484 TMEM38B 0.44 6.36 0.33 6.72e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs8017423 0.935 rs3742667 chr14:90767856 T/C cg14092571 chr14:90743983 NA 0.36 5.8 0.3 1.58e-8 Mortality in heart failure; LUSC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg18404041 chr3:52824283 ITIH1 0.43 7.63 0.39 2.46e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg05025164 chr4:1340916 KIAA1530 0.4 5.91 0.31 8.66e-9 Obesity-related traits; LUSC cis rs1595825 0.891 rs73054825 chr2:198636355 G/C cg10547527 chr2:198650123 BOLL -0.52 -6.07 -0.31 3.57e-9 Ulcerative colitis; LUSC cis rs4474465 0.688 rs10751296 chr11:78277277 C/T cg27205649 chr11:78285834 NARS2 -0.56 -6.87 -0.35 3.11e-11 Alzheimer's disease (survival time); LUSC cis rs2235642 0.821 rs2281234 chr16:1602938 A/G cg26528668 chr16:1614120 IFT140 0.47 7.95 0.4 2.83e-14 Coronary artery disease; LUSC cis rs2357013 0.752 rs55992015 chr2:53170717 C/T cg07782112 chr2:53107842 NA -0.39 -6.25 -0.32 1.23e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs3087591 0.922 rs12939969 chr17:29463577 A/G cg24425628 chr17:29625626 OMG;NF1 0.54 7.89 0.4 4.39e-14 Hip circumference; LUSC cis rs9790314 0.690 rs6441354 chr3:160826404 A/G cg03342759 chr3:160939853 NMD3 -0.41 -6.63 -0.34 1.32e-10 Morning vs. evening chronotype; LUSC cis rs4974559 0.790 rs7654152 chr4:1325042 G/A cg02980000 chr4:1222292 CTBP1 0.97 9.05 0.44 1.17e-17 Systolic blood pressure; LUSC cis rs2652834 0.904 rs2937859 chr15:63366282 C/T cg05507819 chr15:63340323 TPM1 0.71 9.15 0.45 5.9e-18 HDL cholesterol; LUSC cis rs7202877 0.610 rs4888381 chr16:75356847 C/A cg04384234 chr16:75411784 CFDP1 -0.62 -8.55 -0.42 4.57e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs977987 0.750 rs4888406 chr16:75432334 G/T cg03315344 chr16:75512273 CHST6 0.54 10.38 0.49 4.79e-22 Dupuytren's disease; LUSC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -11.96 -0.55 1.08e-27 Personality dimensions; LUSC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg05855489 chr10:104503620 C10orf26 -0.67 -9.93 -0.48 1.62e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg24812749 chr6:127587940 RNF146 0.92 13.86 0.6 7.74e-35 Breast cancer; LUSC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg22920501 chr2:26401640 FAM59B -0.74 -10.85 -0.51 1.06e-23 Gut microbiome composition (summer); LUSC cis rs757081 0.667 rs12577525 chr11:17260116 G/A cg15432903 chr11:17409602 KCNJ11 -0.36 -5.69 -0.3 2.77e-8 Systolic blood pressure; LUSC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg27539214 chr16:67997921 SLC12A4 -0.55 -7.33 -0.37 1.75e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg16049864 chr8:95962084 TP53INP1 -0.64 -12.73 -0.57 1.52e-30 Type 2 diabetes; LUSC cis rs4927850 0.666 rs4927853 chr3:195752053 G/C cg00031303 chr3:195681400 NA 0.75 10.94 0.51 5.04e-24 Pancreatic cancer; LUSC cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -8.21 -0.41 4.93e-15 Schizophrenia; LUSC cis rs478304 0.654 rs11601509 chr11:65456864 T/C cg27068330 chr11:65405492 SIPA1 -0.74 -10.3 -0.49 8.46e-22 Acne (severe); LUSC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg08680598 chr22:49984980 NA -0.33 -6.13 -0.32 2.53e-9 Monocyte count;Monocyte percentage of white cells; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25867694 chr22:31503597 SELM -0.47 -6.0 -0.31 5.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs9398803 0.965 rs2027299 chr6:126685827 G/C cg19875578 chr6:126661172 C6orf173 0.39 5.83 0.3 1.31e-8 Male-pattern baldness; LUSC cis rs2346177 0.844 rs13010062 chr2:46644137 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.58 -0.38 3.43e-13 HDL cholesterol; LUSC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg05472934 chr7:22766657 IL6 0.54 8.46 0.42 8.79e-16 Lung cancer; LUSC cis rs10740039 0.883 rs10761544 chr10:62415405 C/A cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7216064 1.000 rs4791299 chr17:65930937 A/G cg12091567 chr17:66097778 LOC651250 -0.72 -9.56 -0.46 2.67e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg14664628 chr15:75095509 CSK -0.53 -7.77 -0.39 1e-13 Breast cancer; LUSC cis rs9486719 1.000 rs2472895 chr6:96870387 A/T cg06623918 chr6:96969491 KIAA0776 0.8 9.93 0.48 1.57e-20 Migraine;Coronary artery disease; LUSC cis rs9427116 0.502 rs903323 chr1:154572228 A/G cg17218026 chr1:154582156 ADAR -0.56 -10.08 -0.48 4.72e-21 Blood protein levels; LUSC cis rs10254118 0.757 rs6467491 chr7:133138761 A/G cg10665199 chr7:133106180 EXOC4 0.59 8.08 0.4 1.19e-14 Intelligence (multi-trait analysis); LUSC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg05776053 chr2:74358815 NA 0.46 7.31 0.37 1.94e-12 Gestational age at birth (maternal effect); LUSC cis rs4692589 0.606 rs12645495 chr4:170933909 T/C cg19918862 chr4:170955249 NA 0.38 7.02 0.36 1.23e-11 Anxiety disorder; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg20243544 chr17:37824526 PNMT 0.39 5.76 0.3 1.96e-8 Self-reported allergy; LUSC cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 28.4 0.84 4.39e-91 Chronic sinus infection; LUSC cis rs10779751 0.690 rs2791646 chr1:11133242 C/T cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.77e-29 Body mass index; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg02731540 chr11:31391568 DCDC1;DNAJC24 0.34 6.0 0.31 5.18e-9 Tuberculosis; LUSC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg06850241 chr22:41845214 NA 0.34 6.3 0.33 9.5e-10 Vitiligo; LUSC cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg15556689 chr8:8085844 FLJ10661 0.72 12.16 0.55 2.12e-28 Mood instability; LUSC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg15605315 chr1:45957053 TESK2 0.46 7.54 0.38 4.34e-13 High light scatter reticulocyte count; LUSC cis rs7607369 0.580 rs7594289 chr2:219652286 A/G cg02176678 chr2:219576539 TTLL4 -0.67 -13.27 -0.59 1.38e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs6494488 0.500 rs72744704 chr15:65011507 G/A cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg09877947 chr5:131593287 PDLIM4 -0.46 -7.06 -0.36 9.84e-12 Blood metabolite levels; LUSC cis rs4595586 0.546 rs11169801 chr12:39241429 G/A cg13010199 chr12:38710504 ALG10B 0.63 9.25 0.45 2.81e-18 Morning vs. evening chronotype; LUSC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03264133 chr6:25882463 NA 0.47 8.7 0.43 1.54e-16 Blood metabolite levels; LUSC cis rs11190604 0.945 rs11190573 chr10:102233172 T/C cg07080220 chr10:102295463 HIF1AN 0.64 8.46 0.42 8.63e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.69 0.39 1.71e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7106204 0.609 rs12801799 chr11:24300630 A/T ch.11.24196551F chr11:24239977 NA 0.71 5.95 0.31 6.89e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg24399712 chr22:39784796 NA -0.65 -12.13 -0.55 2.73e-28 Intelligence (multi-trait analysis); LUSC cis rs955333 0.925 rs56344141 chr6:154927189 G/T cg20019720 chr6:154832845 CNKSR3 0.46 5.84 0.3 1.26e-8 Diabetic kidney disease; LUSC cis rs7178572 1.000 rs34591043 chr15:77713586 A/G cg22256960 chr15:77711686 NA -0.54 -9.02 -0.44 1.51e-17 Type 2 diabetes; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs72960926 0.744 rs56020332 chr6:75030022 C/G cg03266952 chr6:74778945 NA -0.83 -7.03 -0.36 1.14e-11 Metabolite levels (MHPG); LUSC cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg03709012 chr19:19516395 GATAD2A -0.8 -12.76 -0.57 1.25e-30 Tonsillectomy; LUSC cis rs8099014 0.770 rs1135519 chr18:56117145 C/T cg12907477 chr18:56117327 MIR122 0.45 7.05 0.36 1.01e-11 Platelet count; LUSC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg02711726 chr17:80685570 FN3KRP -0.42 -6.48 -0.33 3.22e-10 Glycated hemoglobin levels; LUSC cis rs1775715 0.674 rs2778670 chr10:32161676 G/A cg26784012 chr10:32216390 ARHGAP12 0.45 7.77 0.39 9.75e-14 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg08975724 chr8:8085496 FLJ10661 -0.47 -6.61 -0.34 1.55e-10 Triglycerides; LUSC cis rs950169 0.881 rs34117475 chr15:85108443 T/C cg12863693 chr15:85201151 NMB 0.35 7.11 0.36 7.15e-12 Schizophrenia; LUSC cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg26647111 chr11:31128758 NA -0.43 -6.13 -0.32 2.47e-9 Red blood cell count; LUSC cis rs2692947 0.727 rs749459 chr2:96795714 G/A cg22654517 chr2:96458247 NA 0.35 6.78 0.35 5.34e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.24 0.45 2.87e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7020830 0.931 rs13297576 chr9:37142189 A/C cg14294708 chr9:37120828 ZCCHC7 1.12 26.1 0.82 1.27e-82 Schizophrenia; LUSC cis rs7605827 0.930 rs4668898 chr2:15511502 T/C cg19274914 chr2:15703543 NA 0.46 8.89 0.44 3.98e-17 Educational attainment (years of education); LUSC cis rs9479482 0.789 rs12204988 chr6:150339315 T/G cg25797454 chr6:150327115 RAET1K 0.37 8.57 0.42 3.82e-16 Alopecia areata; LUSC cis rs6456156 0.586 rs2285148 chr6:167490999 G/T cg06454157 chr6:167490870 NA -0.28 -6.38 -0.33 5.76e-10 Primary biliary cholangitis; LUSC cis rs7617480 0.648 rs6806356 chr3:48727636 G/A cg07636037 chr3:49044803 WDR6 0.77 10.02 0.48 7.64e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs8113142 0.614 rs2108771 chr19:29187422 C/T cg04546413 chr19:29218101 NA 0.44 5.99 0.31 5.4e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg24503407 chr1:205819492 PM20D1 0.83 14.37 0.62 8.47e-37 Menarche (age at onset); LUSC cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.53 -0.34 2.52e-10 Colorectal cancer; LUSC cis rs4555082 1.000 rs4555082 chr14:105758964 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.72 -0.39 1.36e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs11605924 0.967 rs6485646 chr11:45865764 G/A ch.11.939596F chr11:45881766 CRY2 -0.54 -8.12 -0.41 9.37e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg00012203 chr2:219082015 ARPC2 -0.57 -9.07 -0.44 1.08e-17 Ulcerative colitis; LUSC cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg03188948 chr7:1209495 NA 0.49 6.23 0.32 1.39e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg26384229 chr12:38710491 ALG10B 0.87 14.22 0.61 3.36e-36 Bladder cancer; LUSC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg00933542 chr6:150070202 PCMT1 -0.29 -6.03 -0.31 4.42e-9 Lung cancer; LUSC cis rs8072100 0.805 rs67919208 chr17:45771873 T/C cg19784903 chr17:45786737 TBKBP1 -0.4 -6.43 -0.33 4.33e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs453301 0.686 rs3895823 chr8:8873646 T/C cg15556689 chr8:8085844 FLJ10661 -0.61 -9.44 -0.46 6.52e-19 Joint mobility (Beighton score); LUSC cis rs2835872 0.758 rs1709833 chr21:39037805 C/T cg20424643 chr21:39039972 KCNJ6 0.44 7.53 0.38 4.67e-13 Electroencephalographic traits in alcoholism; LUSC cis rs6500395 0.926 rs1039342 chr16:48577498 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.34 0.33 7.63e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs72781680 1.000 rs56205282 chr2:24221317 C/T cg20701182 chr2:24300061 SF3B14 0.76 7.7 0.39 1.59e-13 Lymphocyte counts; LUSC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg07741184 chr6:167504864 NA 0.34 6.1 0.32 2.92e-9 Crohn's disease; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg00760200 chr1:115053833 TRIM33 0.4 5.99 0.31 5.42e-9 Mosquito bite size; LUSC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.05 -0.36 1.05e-11 Major depressive disorder; LUSC cis rs6598955 0.671 rs11247905 chr1:26627907 G/C cg00852783 chr1:26633632 UBXN11 -0.5 -5.86 -0.31 1.13e-8 Obesity-related traits; LUSC cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg00071950 chr4:10020882 SLC2A9 -0.51 -8.45 -0.42 9.36e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs77741769 0.571 rs11065300 chr12:121298512 G/C cg02419362 chr12:121203948 SPPL3 0.45 8.41 0.42 1.18e-15 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs2274273 0.516 rs3759665 chr14:55371605 C/T cg04306507 chr14:55594613 LGALS3 0.32 6.0 0.31 5.19e-9 Protein biomarker; LUSC cis rs72781680 1.000 rs72781667 chr2:24225667 A/G cg08917208 chr2:24149416 ATAD2B 0.9 10.11 0.48 3.82e-21 Lymphocyte counts; LUSC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg02415014 chr8:143852576 LYNX1 0.34 8.21 0.41 4.99e-15 Urinary tract infection frequency; LUSC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg23711669 chr6:146136114 FBXO30 0.72 11.07 0.52 1.74e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg03233332 chr7:66118400 NA -0.41 -6.02 -0.31 4.49e-9 Aortic root size; LUSC cis rs9398803 0.687 rs4549631 chr6:126966308 A/G cg19875578 chr6:126661172 C6orf173 0.43 6.28 0.32 1.08e-9 Male-pattern baldness; LUSC cis rs1408224 0.626 rs912434 chr13:47189928 G/T cg19833103 chr13:47126551 LRCH1 -0.39 -5.73 -0.3 2.27e-8 QRS complex (12-leadsum); LUSC cis rs9443189 0.570 rs659807 chr6:76293435 C/A cg01950844 chr6:76311363 SENP6 0.7 6.98 0.36 1.63e-11 Prostate cancer; LUSC cis rs10751667 0.666 rs4074235 chr11:977511 C/G ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.3e-10 Alzheimer's disease (late onset); LUSC cis rs6062509 1.000 rs6011066 chr20:62364180 G/A cg01176363 chr20:62369445 LIME1 -0.47 -6.98 -0.36 1.62e-11 Prostate cancer; LUSC cis rs929354 0.772 rs2023975 chr7:157012096 G/A cg17757837 chr7:157058334 UBE3C 0.81 13.12 0.58 5.09e-32 Body mass index; LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.09 15.49 0.65 3.62e-41 Gut microbiome composition (summer); LUSC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 0.58 7.11 0.36 7.02e-12 Lung function (FEV1/FVC); LUSC cis rs17102423 0.602 rs1007914 chr14:65566261 C/A cg11161011 chr14:65562177 MAX -0.77 -11.44 -0.53 8.43e-26 Obesity-related traits; LUSC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.01 0.4 1.9e-14 Parkinson's disease; LUSC cis rs9837602 1.000 rs9832186 chr3:99728503 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.09 -0.32 3.14e-9 Breast cancer; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg10150615 chr22:24372951 LOC391322 -0.38 -6.31 -0.33 8.91e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg03732007 chr1:2071316 PRKCZ -0.53 -9.45 -0.46 6.24e-19 Height; LUSC cis rs4663866 1.000 rs6734408 chr2:239137481 A/C cg16914508 chr2:239161102 PER2 0.62 6.58 0.34 1.79e-10 Irritable bowel syndrome; LUSC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs4561483 0.864 rs190461 chr16:12005745 A/G cg08843971 chr16:11963173 GSPT1 -0.46 -6.72 -0.35 7.8e-11 Testicular germ cell tumor; LUSC cis rs10751667 0.600 rs4076915 chr11:1012464 C/G ch.11.42038R chr11:967971 AP2A2 0.45 6.58 0.34 1.79e-10 Alzheimer's disease (late onset); LUSC cis rs7937682 0.889 rs559482 chr11:111497902 G/A cg09085632 chr11:111637200 PPP2R1B -1.14 -18.36 -0.71 1.46e-52 Primary sclerosing cholangitis; LUSC cis rs2361710 0.704 rs12937349 chr17:78120320 G/C cg09238746 chr17:78121135 EIF4A3 -0.65 -10.17 -0.49 2.39e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs3213545 0.659 rs2259690 chr12:121457914 T/G cg02403541 chr12:121454288 C12orf43 0.61 9.51 0.46 3.8e-19 Subjective well-being;Cardiovascular disease risk factors; LUSC cis rs6084875 0.812 rs2422938 chr20:4721926 G/C cg26097573 chr20:4721490 PRNT -0.31 -5.7 -0.3 2.69e-8 Systemic lupus erythematosus; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg15147215 chr3:52552868 STAB1 -0.35 -6.84 -0.35 3.78e-11 Electroencephalogram traits; LUSC trans rs7939886 0.920 rs7946368 chr11:55804219 C/T cg03929089 chr4:120376271 NA 0.74 6.28 0.32 1.07e-9 Myopia (pathological); LUSC cis rs11122272 0.735 rs2790889 chr1:231520240 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs4903604 0.581 rs11159278 chr14:78034001 C/G cg18872420 chr14:78023429 SPTLC2 0.4 6.06 0.31 3.75e-9 Gut microbiome composition (winter); LUSC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg04727924 chr7:799746 HEATR2 -0.57 -6.06 -0.31 3.75e-9 Cerebrospinal P-tau181p levels; LUSC cis rs748404 0.697 rs493444 chr15:43566470 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.44 6.12 0.32 2.57e-9 Lung cancer; LUSC cis rs2652834 1.000 rs7182618 chr15:63398622 T/C cg05507819 chr15:63340323 TPM1 0.66 7.98 0.4 2.39e-14 HDL cholesterol; LUSC trans rs61931739 0.635 rs10743836 chr12:33961680 C/T cg13010199 chr12:38710504 ALG10B 0.4 6.03 0.31 4.38e-9 Morning vs. evening chronotype; LUSC cis rs367615 0.704 rs4320313 chr5:108828687 A/G cg17395555 chr5:108820864 NA 0.64 11.35 0.53 1.82e-25 Colorectal cancer (SNP x SNP interaction); LUSC trans rs953492 0.517 rs2247527 chr1:243309983 A/C cg01826367 chr1:224180288 NA 0.44 6.47 0.33 3.43e-10 Diastolic blood pressure; LUSC cis rs7107174 1.000 rs10793308 chr11:78086005 C/T cg02023728 chr11:77925099 USP35 0.43 6.47 0.33 3.57e-10 Testicular germ cell tumor; LUSC cis rs10782582 0.593 rs11163904 chr1:76121208 A/G cg03433033 chr1:76189801 ACADM 0.46 7.07 0.36 9.21e-12 Daytime sleep phenotypes; LUSC cis rs10489202 0.608 rs3753934 chr1:168074677 C/T cg24449463 chr1:168025552 DCAF6 -0.64 -9.68 -0.47 1.05e-19 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26481784 chr15:35837840 ATPBD4 0.44 6.01 0.31 4.77e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg04673462 chr1:38461896 NA -0.5 -7.61 -0.38 2.87e-13 Coronary artery disease; LUSC trans rs12692738 0.526 rs355853 chr2:165627618 T/C cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg18301423 chr5:131593218 PDLIM4 0.41 6.45 0.33 3.93e-10 Blood metabolite levels; LUSC cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC cis rs10751667 0.580 rs10751664 chr11:927077 T/G ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.65e-9 Alzheimer's disease (late onset); LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg16405210 chr4:1374714 KIAA1530 -0.57 -8.8 -0.43 7.35e-17 Obesity-related traits; LUSC cis rs11252926 0.770 rs4880736 chr10:680133 C/G cg18196295 chr10:418757 DIP2C 0.38 5.9 0.31 8.94e-9 Psychosis in Alzheimer's disease; LUSC cis rs208520 1.000 rs12190316 chr6:66973365 T/C cg07460842 chr6:66804631 NA 0.95 12.04 0.55 5.59e-28 Exhaled nitric oxide output; LUSC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.23 -0.32 1.42e-9 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16316507 chr7:144533041 TPK1 0.51 6.96 0.36 1.82e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.95 0.44 2.52e-17 Prudent dietary pattern; LUSC cis rs9902453 0.845 rs2617865 chr17:28049804 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -9.38 -0.46 1.06e-18 Coffee consumption (cups per day); LUSC cis rs7043114 0.507 rs6479420 chr9:95116406 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.6 -0.34 1.6e-10 Height; LUSC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg15445000 chr17:37608096 MED1 -0.39 -6.8 -0.35 4.94e-11 Glomerular filtration rate (creatinine); LUSC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg26408565 chr15:76604113 ETFA 0.47 7.68 0.39 1.81e-13 Blood metabolite levels; LUSC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.15 0.32 2.23e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12681288 0.862 rs7814070 chr8:1020991 A/G cg15309053 chr8:964076 NA 0.31 6.03 0.31 4.3e-9 Schizophrenia; LUSC cis rs951366 0.576 rs1832775 chr1:205734032 C/T cg24503407 chr1:205819492 PM20D1 -0.47 -6.28 -0.32 1.06e-9 Menarche (age at onset); LUSC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs7980799 0.565 rs2200159 chr12:33648544 G/C cg13010199 chr12:38710504 ALG10B -0.4 -5.95 -0.31 6.71e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg22875332 chr1:76189707 ACADM 0.71 9.82 0.47 3.6e-20 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs1922233 0.943 rs1922235 chr4:92367917 G/A cg24250684 chr1:219729030 NA -0.34 -6.08 -0.32 3.19e-9 Gut microbiome composition (summer and winter); LUSC cis rs1190552 0.739 rs1998421 chr14:102979644 C/T cg18135206 chr14:102964638 TECPR2 0.46 5.76 0.3 1.92e-8 Blood protein levels; LUSC cis rs9467773 1.000 rs9467773 chr6:26498426 A/G cg09904177 chr6:26538194 HMGN4 0.72 13.02 0.58 1.28e-31 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.7 -0.7 6.65e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs4478858 0.709 rs937786 chr1:31857869 G/A cg00250761 chr1:31883323 NA 0.33 7.46 0.38 7.59e-13 Alcohol dependence; LUSC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.67 -10.38 -0.49 4.48e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4842666 0.915 rs2681472 chr12:90008959 A/G cg00757033 chr12:89920650 WDR51B 0.47 6.31 0.33 8.99e-10 Blood pressure; LUSC cis rs2425143 1.000 rs6058303 chr20:34290281 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -6.16 -0.32 2.04e-9 Blood protein levels; LUSC cis rs11650494 0.710 rs61427980 chr17:47473580 A/G cg08112188 chr17:47440006 ZNF652 0.93 7.93 0.4 3.3e-14 Prostate cancer; LUSC cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg08564027 chr20:61660810 NA 0.93 17.11 0.68 1.47e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs9807989 0.839 rs10204137 chr2:102968212 A/G cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC trans rs12310956 0.532 rs11052933 chr12:33969881 G/A cg26384229 chr12:38710491 ALG10B 0.74 11.77 0.54 5.6e-27 Morning vs. evening chronotype; LUSC cis rs3764563 1.000 rs4239612 chr19:15727442 A/G cg20725493 chr19:15740067 CYP4F8 -0.63 -6.2 -0.32 1.62e-9 Inflammatory biomarkers; LUSC cis rs9653442 0.545 rs4851252 chr2:100757280 C/T cg22139774 chr2:100720529 AFF3 -0.4 -6.63 -0.34 1.36e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs10883499 chr10:102232188 T/A cg16342193 chr10:102329863 NA -0.35 -6.24 -0.32 1.32e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4901869 0.966 rs12148052 chr14:59338970 C/T cg02291164 chr14:59296302 NA 0.58 11.11 0.52 1.33e-24 Panic disorder; LUSC cis rs2204008 0.560 rs1315354 chr12:38165716 A/G cg13010199 chr12:38710504 ALG10B -0.52 -7.91 -0.4 3.89e-14 Bladder cancer; LUSC cis rs9807989 0.507 rs2041739 chr2:102994333 A/G cg03938978 chr2:103052716 IL18RAP -0.37 -6.98 -0.36 1.61e-11 Asthma; LUSC cis rs6681460 0.899 rs502690 chr1:67182403 A/T cg02459107 chr1:67143332 SGIP1 0.48 8.92 0.44 3.24e-17 Presence of antiphospholipid antibodies; LUSC cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg21918786 chr6:109611834 NA -0.4 -6.96 -0.36 1.79e-11 Reticulocyte fraction of red cells; LUSC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 12.7 0.57 2.1000000000000002e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.56 -0.34 2.02e-10 Lung cancer; LUSC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg18876405 chr7:65276391 NA 0.55 8.59 0.43 3.48e-16 Aortic root size; LUSC cis rs9487051 0.799 rs351724 chr6:109546577 T/C cg01475377 chr6:109611718 NA -0.35 -5.83 -0.3 1.28e-8 Reticulocyte fraction of red cells; LUSC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg16624210 chr5:671434 TPPP 0.5 6.2 0.32 1.63e-9 Lung disease severity in cystic fibrosis; LUSC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs2120243 0.572 rs3816528 chr3:157127290 C/T cg01018701 chr3:157155998 VEPH1;PTX3 -0.36 -5.7 -0.3 2.6e-8 Hepatocellular carcinoma in hepatitis B infection; LUSC cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg08807101 chr21:30365312 RNF160 -0.73 -12.82 -0.57 7.16e-31 Dental caries; LUSC cis rs2839186 0.739 rs7282763 chr21:47696800 C/T cg11766577 chr21:47581405 C21orf56 -0.43 -6.41 -0.33 4.9e-10 Testicular germ cell tumor; LUSC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg16049864 chr8:95962084 TP53INP1 -0.66 -12.16 -0.55 1.97e-28 Type 2 diabetes; LUSC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg20476274 chr7:133979776 SLC35B4 0.83 15.25 0.64 3.29e-40 Mean platelet volume; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.93e-29 Prudent dietary pattern; LUSC cis rs12542260 0.871 rs7836802 chr8:125473730 C/T cg27038428 chr8:125485867 RNF139 0.33 6.68 0.34 9.77e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs8062405 0.723 rs4788077 chr16:28569764 G/C cg16576597 chr16:28551801 NUPR1 0.34 6.79 0.35 5.07e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.57 -8.64 -0.43 2.3e-16 Alzheimer's disease (late onset); LUSC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg20573242 chr4:122745356 CCNA2 0.63 9.34 0.46 1.36e-18 Type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26706201 chr11:57103334 SSRP1 0.42 6.41 0.33 5.07e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11471957 1 rs11471957 chr20:57598332 C/CAA cg14073986 chr20:57617431 SLMO2 0.59 6.58 0.34 1.86e-10 Platelet count;Mean platelet volume; LUSC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg24397884 chr7:158709396 WDR60 0.6 9.28 0.45 2.26e-18 Height; LUSC cis rs7833986 0.501 rs2719257 chr8:56940173 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.73 11.94 0.55 1.27e-27 Height; LUSC cis rs3733418 0.929 rs4691138 chr4:165908641 A/G cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -5.92 -0.31 7.89e-9 Obesity-related traits; LUSC cis rs2346177 0.874 rs11125075 chr2:46656344 A/G cg02822958 chr2:46747628 ATP6V1E2 0.37 6.45 0.33 4.04e-10 HDL cholesterol; LUSC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.63 0.5 6.47e-23 Menopause (age at onset); LUSC cis rs11122272 0.735 rs2491408 chr1:231519248 C/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs1861353 0.863 rs16952252 chr16:53483980 G/T cg09728985 chr16:53543985 NA -0.32 -6.1 -0.32 2.88e-9 Intelligence (multi-trait analysis); LUSC cis rs709400 0.663 rs72708893 chr14:103929535 G/A cg24130564 chr14:104152367 KLC1 -0.44 -6.13 -0.32 2.53e-9 Body mass index; LUSC cis rs9517320 0.534 rs9554474 chr13:99140871 G/A cg20487152 chr13:99095054 FARP1 -0.45 -7.84 -0.39 5.93e-14 Longevity; LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03934478 chr11:495069 RNH1 0.91 10.38 0.49 4.61e-22 Body mass index; LUSC cis rs1048238 0.506 rs598371 chr1:16212739 G/A cg21385522 chr1:16154831 NA -0.55 -8.29 -0.41 2.72e-15 Systolic blood pressure; LUSC cis rs8062405 0.723 rs12445744 chr16:28588395 A/C cg16576597 chr16:28551801 NUPR1 0.34 6.87 0.35 3.15e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1577917 0.771 rs2842601 chr6:86330133 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.1 -0.52 1.36e-24 Response to antipsychotic treatment; LUSC cis rs859767 0.709 rs1516990 chr2:135369630 C/G cg12500956 chr2:135428796 TMEM163 -0.28 -6.43 -0.33 4.49e-10 Neuroticism; LUSC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg08270630 chr22:50330655 NA -0.39 -5.93 -0.31 7.36e-9 Schizophrenia; LUSC cis rs11077998 0.967 rs7502945 chr17:80495039 T/C cg10255544 chr17:80519551 FOXK2 0.4 6.57 0.34 1.88e-10 Reticulocyte fraction of red cells; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg02018176 chr4:1364513 KIAA1530 0.52 8.88 0.44 4.11e-17 Obesity-related traits; LUSC cis rs12101261 1.000 rs8003061 chr14:81451956 G/A cg06600135 chr14:81408086 NA 0.44 6.48 0.33 3.38e-10 Graves' disease; LUSC cis rs1113500 0.614 rs6677839 chr1:108599341 G/T cg11967332 chr1:108735228 SLC25A24 -0.42 -5.91 -0.31 8.29e-9 Growth-regulated protein alpha levels; LUSC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.03 -0.31 4.25e-9 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2572253 chr1:231512768 C/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg26446133 chr18:72167187 CNDP2 -0.85 -13.41 -0.59 4.32e-33 Refractive error; LUSC cis rs9886651 0.776 rs12155669 chr8:128779931 A/G cg07795030 chr8:128802207 NA 0.36 6.56 0.34 2.01e-10 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg24642439 chr20:33292090 TP53INP2 0.72 11.69 0.54 1.07e-26 Coronary artery disease; LUSC cis rs2303759 0.670 rs45549132 chr19:49794028 G/T cg24324837 chr19:49891574 CCDC155 0.45 5.78 0.3 1.74e-8 Multiple sclerosis; LUSC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg06238570 chr21:40685208 BRWD1 0.48 7.37 0.37 1.34e-12 Cognitive function; LUSC cis rs11098499 0.863 rs3822190 chr4:120428098 G/A cg24375607 chr4:120327624 NA 0.75 11.04 0.52 2.38e-24 Corneal astigmatism; LUSC cis rs71718386 1 rs71718386 chr13:41224287 CTATA/C cg21288729 chr13:41239152 FOXO1 0.65 10.04 0.48 6.48e-21 Eosinophil counts; LUSC cis rs6700896 0.832 rs11208693 chr1:66108063 C/T cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs600626 0.636 rs11236514 chr11:75451343 A/C cg24262691 chr11:75473276 NA -0.45 -5.89 -0.31 9.61e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs6500395 1.000 rs8059819 chr16:48682834 A/G cg04672837 chr16:48644449 N4BP1 -0.48 -7.31 -0.37 1.94e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg15595755 chr5:1867978 NA 0.46 8.29 0.41 2.73e-15 Cardiovascular disease risk factors; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15730116 chr12:76953768 OSBPL8 -0.47 -6.07 -0.32 3.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg06697600 chr4:7070879 GRPEL1 -0.4 -6.61 -0.34 1.49e-10 Monocyte percentage of white cells; LUSC cis rs10193935 1.000 rs12622910 chr2:42398918 C/A cg27598129 chr2:42591480 NA -0.6 -8.03 -0.4 1.65e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs4845570 0.749 rs11576810 chr1:151712201 C/G cg07092448 chr1:151763213 TDRKH -1.05 -10.93 -0.51 5.7e-24 Coronary artery disease; LUSC cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.3 0.56 6.15e-29 Colorectal cancer; LUSC trans rs7829975 0.688 rs7837587 chr8:8378992 T/C cg27411982 chr8:10470053 RP1L1 0.45 7.46 0.38 7.56e-13 Mood instability; LUSC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7223966 1.000 rs15637 chr17:61772050 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.34 0.37 1.64e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg12963246 chr6:28129442 ZNF389 0.45 6.09 0.32 3.16e-9 Parkinson's disease; LUSC cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs11031096 0.502 rs1442726 chr11:4094748 G/C cg08557956 chr11:4115526 RRM1 -0.46 -5.83 -0.3 1.31e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg01475377 chr6:109611718 NA -0.46 -8.39 -0.42 1.4e-15 Reticulocyte fraction of red cells; LUSC cis rs9650315 0.850 rs6984782 chr8:57135889 C/T cg23139584 chr8:56987506 RPS20;SNORD54 -0.54 -7.25 -0.37 2.83e-12 Height; LUSC trans rs2288327 1.000 rs2288327 chr2:179411665 A/G cg14011486 chr1:26737247 LIN28 0.47 6.06 0.31 3.77e-9 Atrial fibrillation; LUSC cis rs7481584 0.624 rs2106229 chr11:3041195 G/A cg05729581 chr11:3078854 CARS 0.4 6.0 0.31 5.01e-9 Calcium levels; LUSC trans rs6076960 0.623 rs6038407 chr20:6267326 A/G cg21095983 chr6:86352623 SYNCRIP 0.57 8.83 0.44 5.94e-17 Smooth-surface caries; LUSC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs870825 0.616 rs10428373 chr4:185639002 A/T cg04058563 chr4:185651563 MLF1IP 0.87 13.55 0.6 1.23e-33 Blood protein levels; LUSC cis rs7216064 1.000 rs62085993 chr17:65923152 T/C cg12091567 chr17:66097778 LOC651250 -0.71 -9.12 -0.45 7.15e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs80130819 0.688 rs10783232 chr12:48583491 A/G cg24011408 chr12:48396354 COL2A1 0.45 5.87 0.31 1.05e-8 Prostate cancer; LUSC cis rs7539542 0.556 rs2000331 chr1:202857578 G/T cg19681188 chr1:202830198 LOC148709 0.41 6.03 0.31 4.23e-9 Mean platelet volume; LUSC cis rs1185460 0.934 rs1006195 chr11:118958869 A/C cg01677386 chr11:118938358 VPS11 0.44 6.09 0.32 3.14e-9 Coronary artery disease; LUSC cis rs73001065 0.901 rs739846 chr19:19419071 G/A cg03709012 chr19:19516395 GATAD2A 0.89 6.89 0.35 2.79e-11 LDL cholesterol; LUSC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg04450456 chr4:17643702 FAM184B 0.33 5.74 0.3 2.08e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs737008 0.922 rs28567501 chr16:11378928 C/A cg00044050 chr16:11439710 C16orf75 -0.52 -8.01 -0.4 1.89e-14 Obesity-related traits; LUSC cis rs6754311 0.773 rs309179 chr2:136613780 G/A cg25344623 chr2:136566232 LCT 0.37 5.68 0.3 2.96e-8 Mosquito bite size; LUSC trans rs6951245 0.554 rs78999139 chr7:1138525 G/A cg13565492 chr6:43139072 SRF -0.73 -10.83 -0.51 1.25e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg01028140 chr2:1542097 TPO -0.6 -8.02 -0.4 1.86e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00330279 chr16:87584184 NA -0.42 -6.05 -0.31 3.97e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs738321 0.762 rs5995543 chr22:38579026 G/A cg25457927 chr22:38595422 NA -0.43 -8.09 -0.4 1.15e-14 Breast cancer; LUSC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg11764359 chr7:65958608 NA 0.54 7.11 0.36 7.23e-12 Aortic root size; LUSC trans rs1005277 0.541 rs2472177 chr10:38384015 T/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.72 -0.47 8.18e-20 Extrinsic epigenetic age acceleration; LUSC cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg11584989 chr19:19387371 SF4 0.61 7.38 0.37 1.25e-12 Bipolar disorder; LUSC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg18131467 chr2:239335373 ASB1 0.87 13.84 0.6 9.42e-35 Multiple system atrophy; LUSC cis rs9905704 0.709 rs758378 chr17:56607746 G/C cg12560992 chr17:57184187 TRIM37 -0.48 -5.85 -0.3 1.19e-8 Testicular germ cell tumor; LUSC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg15605315 chr1:45957053 TESK2 0.51 8.43 0.42 1.06e-15 High light scatter reticulocyte count; LUSC cis rs67311347 0.544 rs7644643 chr3:40350209 C/T cg02782426 chr3:40428986 ENTPD3 -0.28 -5.74 -0.3 2.16e-8 Renal cell carcinoma; LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg24060327 chr5:131705240 SLC22A5 -0.67 -11.55 -0.53 3.51e-26 Breast cancer; LUSC cis rs79349575 0.783 rs55771415 chr17:46999937 C/T cg22482690 chr17:47019901 SNF8 0.4 7.59 0.38 3.17e-13 Type 2 diabetes; LUSC cis rs2486288 0.656 rs11632777 chr15:45551045 C/T cg09092052 chr15:45571596 NA 0.46 6.36 0.33 6.52e-10 Glomerular filtration rate; LUSC cis rs7072216 0.881 rs4345897 chr10:100147060 A/G cg26618903 chr10:100175079 PYROXD2 -0.29 -5.72 -0.3 2.36e-8 Metabolite levels; LUSC cis rs983392 0.805 rs7926354 chr11:59962189 G/A cg20284999 chr11:59952153 MS4A6A -0.4 -6.77 -0.35 5.72e-11 Alzheimer's disease (late onset); LUSC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg09655341 chr17:79618100 PDE6G -0.28 -6.58 -0.34 1.86e-10 Eye color traits; LUSC cis rs5758511 0.508 rs2413667 chr22:42472237 A/C cg12850546 chr22:42539477 CYP2D7P1 -0.56 -6.39 -0.33 5.49e-10 Birth weight; LUSC cis rs1801251 1.000 rs2592105 chr2:233645968 C/G cg08000102 chr2:233561755 GIGYF2 0.71 11.68 0.54 1.19e-26 Coronary artery disease; LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg21724239 chr8:58056113 NA 0.79 9.55 0.46 2.99e-19 Developmental language disorder (linguistic errors); LUSC cis rs6138458 0.546 rs6050118 chr20:24891895 C/T cg26195577 chr20:24973756 C20orf3 -0.89 -9.52 -0.46 3.59e-19 Blood protein levels; LUSC cis rs10992471 0.603 rs6479422 chr9:95190694 G/T cg14631576 chr9:95140430 CENPP -0.35 -6.31 -0.33 8.94e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9388451 0.807 rs1268065 chr6:126042783 G/A cg10911889 chr6:126070802 HEY2 -0.39 -5.9 -0.31 8.84e-9 Brugada syndrome; LUSC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.86 0.4 5.35e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg15369054 chr17:80825471 TBCD -0.37 -6.08 -0.32 3.24e-9 Breast cancer; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg14789911 chr21:47582049 C21orf56 0.4 6.42 0.33 4.79e-10 Testicular germ cell tumor; LUSC trans rs72674100 0.737 rs2865756 chr4:97992626 C/T cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1865760 1.000 rs9358893 chr6:25921761 A/G cg16482183 chr6:26056742 HIST1H1C 0.44 6.52 0.34 2.67e-10 Height; LUSC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg09640425 chr7:158790006 NA -0.52 -8.15 -0.41 7.58e-15 Facial morphology (factor 20); LUSC cis rs3540 0.574 rs2256388 chr15:90969335 A/C cg04176472 chr15:90893244 GABARAPL3 -0.32 -5.71 -0.3 2.52e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs72634258 0.554 rs17374781 chr1:7919363 A/G cg00042356 chr1:8021962 PARK7 -0.57 -6.84 -0.35 3.83e-11 Inflammatory bowel disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24170511 chr14:23341280 LRP10 -0.45 -6.73 -0.35 7.51e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs56399783 0.901 rs757788 chr7:2836433 A/G cg14895029 chr7:2775587 GNA12 0.49 5.94 0.31 6.96e-9 Childhood ear infection; LUSC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg12311346 chr5:56204834 C5orf35 0.6 9.06 0.44 1.15e-17 Coronary artery disease; LUSC cis rs6582630 0.615 rs10880642 chr12:38554152 A/G cg26384229 chr12:38710491 ALG10B -0.59 -8.89 -0.44 3.85e-17 Drug-induced liver injury (flucloxacillin); LUSC trans rs2197308 0.659 rs11181327 chr12:37903171 C/T cg06521331 chr12:34319734 NA 0.4 6.24 0.32 1.36e-9 Morning vs. evening chronotype; LUSC cis rs6430585 0.583 rs2322813 chr2:136582809 A/G cg07169764 chr2:136633963 MCM6 1.2 18.36 0.71 1.52e-52 Corneal structure; LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.26 0.64 2.89e-40 Platelet count; LUSC cis rs12318506 0.826 rs34128238 chr12:75731819 T/C cg04728562 chr12:75699417 CAPS2 -0.84 -5.91 -0.31 8.43e-9 Coronary artery calcification; LUSC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs17401966 0.867 rs7546364 chr1:10418815 G/A cg19773385 chr1:10388646 KIF1B -0.5 -8.72 -0.43 1.3e-16 Hepatocellular carcinoma; LUSC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.36 0.33 6.53e-10 Mean platelet volume; LUSC cis rs9811920 0.683 rs7650727 chr3:99688976 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -6.46 -0.33 3.75e-10 Axial length; LUSC cis rs477692 1.000 rs554792 chr10:131423181 A/G cg05714579 chr10:131428358 MGMT 0.5 7.43 0.38 9.36e-13 Response to temozolomide; LUSC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg08499158 chr17:42289980 UBTF -0.49 -8.31 -0.41 2.46e-15 Total body bone mineral density; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg20887711 chr4:1340912 KIAA1530 0.44 6.67 0.34 1.09e-10 Obesity-related traits; LUSC cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 9.43 0.46 6.92e-19 IgG glycosylation; LUSC trans rs6502050 0.835 rs8065210 chr17:80090960 G/A cg07393940 chr7:158741817 NA 0.38 6.88 0.35 2.92e-11 Life satisfaction; LUSC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg24531977 chr5:56204891 C5orf35 -1.03 -15.74 -0.65 3.72e-42 Initial pursuit acceleration; LUSC cis rs7582180 0.614 rs4149518 chr2:101013649 A/G cg12002119 chr2:101014098 CHST10 0.36 6.02 0.31 4.56e-9 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.608 rs12911035 chr15:76606591 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.71 -0.39 1.44e-13 Blood metabolite levels; LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg11645453 chr3:52864694 ITIH4 0.37 8.7 0.43 1.56e-16 Bipolar disorder; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg08888203 chr3:10149979 C3orf24 -0.61 -8.89 -0.44 3.97e-17 Alzheimer's disease; LUSC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg15744005 chr10:104629667 AS3MT -0.29 -6.34 -0.33 7.55e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg13047869 chr3:10149882 C3orf24 0.42 6.44 0.33 4.21e-10 Alzheimer's disease; LUSC cis rs12291225 0.585 rs10832246 chr11:14380828 G/A cg19336497 chr11:14380999 RRAS2 -0.62 -14.05 -0.61 1.42e-35 Sense of smell; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg07092213 chr7:1199455 ZFAND2A 0.56 8.84 0.44 5.44e-17 Longevity;Endometriosis; LUSC cis rs6598955 0.671 rs12145403 chr1:26597189 C/T cg00852783 chr1:26633632 UBXN11 -0.5 -5.77 -0.3 1.84e-8 Obesity-related traits; LUSC cis rs1949733 0.656 rs2688224 chr4:8404700 C/G cg13073564 chr4:8508604 NA -0.44 -8.47 -0.42 8.03e-16 Response to antineoplastic agents; LUSC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg16680214 chr1:154839983 KCNN3 -0.59 -11.53 -0.53 4.07e-26 Prostate cancer; LUSC cis rs7914558 0.933 rs2066323 chr10:104871361 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.55 0.46 2.95e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Bladder cancer; LUSC trans rs561341 1.000 rs508192 chr17:30315147 C/T cg27661571 chr11:113659931 NA 0.62 7.11 0.36 7.18e-12 Hip circumference adjusted for BMI; LUSC trans rs72674100 0.609 rs7677697 chr4:97981842 T/C cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12620999 0.938 rs4575672 chr2:238070572 T/C cg23555395 chr2:238036564 NA -0.47 -8.15 -0.41 7.56e-15 Systemic lupus erythematosus; LUSC cis rs6977660 1.000 rs6977660 chr7:19805480 C/T cg07541023 chr7:19748670 TWISTNB 0.54 6.21 0.32 1.6e-9 Thyroid stimulating hormone; LUSC cis rs9650657 0.741 rs10100333 chr8:10584288 C/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.32 -0.33 8.17e-10 Neuroticism; LUSC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg12641515 chr19:46296257 DMWD 0.48 7.19 0.37 4.36e-12 Coronary artery disease; LUSC cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg00631329 chr6:26305371 NA 0.46 9.3 0.45 1.93e-18 Educational attainment; LUSC cis rs2839186 0.739 rs7282763 chr21:47696800 C/T cg13126279 chr21:47581558 C21orf56 -0.43 -6.37 -0.33 6.09e-10 Testicular germ cell tumor; LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.09 -0.32 3.17e-9 Schizophrenia; LUSC cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg16339924 chr4:17578868 LAP3 0.6 9.3 0.45 1.94e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9462027 0.606 rs2814987 chr6:34605145 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.76 -0.3 1.95e-8 Systemic lupus erythematosus; LUSC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg15595755 chr5:1867978 NA 0.45 8.05 0.4 1.42e-14 Cardiovascular disease risk factors; LUSC cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.62 0.43 2.64e-16 Menarche (age at onset); LUSC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg10356904 chr22:49881777 NA -0.34 -7.69 -0.39 1.69e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.09 -0.36 8.17e-12 Major depressive disorder; LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg11062466 chr8:58055876 NA 0.72 8.8 0.43 7.7e-17 Developmental language disorder (linguistic errors); LUSC cis rs16854884 0.632 rs4535221 chr3:143658607 A/G cg06585982 chr3:143692056 C3orf58 0.48 7.39 0.37 1.17e-12 Economic and political preferences (feminism/equality); LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg15790184 chr11:494944 RNH1 0.61 6.44 0.33 4.27e-10 Body mass index; LUSC cis rs7264396 0.563 rs2050729 chr20:34294409 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.65 8.62 0.43 2.78e-16 Total cholesterol levels; LUSC cis rs950169 0.723 rs17589320 chr15:84919996 C/A cg17507749 chr15:85114479 UBE2QP1 0.67 8.58 0.43 3.57e-16 Schizophrenia; LUSC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.98 0.61 2.7e-35 Platelet count; LUSC trans rs72674100 1.000 rs2865759 chr4:97992416 C/T cg09670535 chr1:18959427 PAX7 -0.62 -6.89 -0.35 2.71e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2092850 1 rs2092850 chr6:88100419 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.37 -5.72 -0.3 2.43e-8 Itch intensity from mosquito bite; LUSC cis rs11676348 0.808 rs61700947 chr2:219046171 C/G cg23569941 chr2:219139048 TMBIM1;PNKD -0.37 -5.89 -0.31 9.2e-9 Ulcerative colitis; LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 16.97 0.68 5.24e-47 Gut microbiome composition (summer); LUSC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg02038168 chr22:39784481 NA -0.43 -6.37 -0.33 6.14e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg04287289 chr16:89883240 FANCA 0.8 14.09 0.61 1.04e-35 Vitiligo; LUSC cis rs9447004 0.584 rs7747167 chr6:74430673 T/G cg03006477 chr6:74432658 CD109 0.27 5.68 0.3 2.85e-8 Blood protein levels;Calcium levels; LUSC cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.75 0.39 1.09e-13 Cognitive ability; LUSC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg22166914 chr1:53195759 ZYG11B -0.73 -12.91 -0.58 3.18e-31 Monocyte count; LUSC trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs3749237 0.929 rs62260715 chr3:49829326 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.9 0.35 2.64e-11 Resting heart rate; LUSC cis rs9287719 0.674 rs1387566 chr2:10828650 C/T cg02196655 chr2:10830764 NOL10 0.34 5.79 0.3 1.64e-8 Prostate cancer; LUSC cis rs3820928 0.804 rs4144327 chr2:227790262 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.38e-13 Pulmonary function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02354839 chr5:72794086 BTF3 -0.41 -6.2 -0.32 1.66e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.55 -8.69 -0.43 1.61e-16 Personality dimensions; LUSC trans rs724744 0.743 rs1205930 chr6:22359007 A/G cg13807341 chr11:118445984 ARCN1 -0.35 -5.96 -0.31 6.54e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg05347473 chr6:146136440 FBXO30 0.48 7.87 0.4 4.9e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg22920501 chr2:26401640 FAM59B -0.74 -10.47 -0.5 2.22e-22 Gut microbiome composition (summer); LUSC cis rs2729354 0.729 rs2729353 chr11:57248003 C/T cg24343310 chr11:57249947 NA 0.46 8.45 0.42 9.18e-16 Blood protein levels; LUSC cis rs1577917 0.958 rs10944168 chr6:86680156 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.61 -0.43 2.96e-16 Response to antipsychotic treatment; LUSC cis rs9976767 0.637 rs9984108 chr21:43825628 T/G cg20516845 chr21:43823604 UBASH3A -0.25 -5.77 -0.3 1.78e-8 Type 1 diabetes; LUSC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.44 0.5 2.97e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs17255340 0.530 rs6923627 chr6:84064858 G/A cg08257003 chr6:84140564 ME1 0.35 8.58 0.42 3.7e-16 Platelet-derived growth factor BB levels; LUSC trans rs3733585 0.699 rs4621431 chr4:9947590 C/T cg26043149 chr18:55253948 FECH -0.43 -6.75 -0.35 6.73e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.25 0.32 1.27e-9 Mean platelet volume; LUSC cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg19628046 chr18:33552617 C18orf21 0.52 6.26 0.32 1.15e-9 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs11250098 0.567 rs4326350 chr8:10763655 C/G cg15556689 chr8:8085844 FLJ10661 0.55 7.73 0.39 1.24e-13 Morning vs. evening chronotype; LUSC cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg08564027 chr20:61660810 NA 0.91 17.35 0.69 1.58e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504073 0.669 rs818558 chr8:50030855 A/G cg00325661 chr8:49890786 NA 0.59 9.58 0.46 2.26e-19 Blood metabolite ratios; LUSC cis rs6840360 0.571 rs4696273 chr4:152528477 G/A cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.66e-10 Intelligence (multi-trait analysis); LUSC cis rs713477 0.901 rs1572612 chr14:55909939 C/T cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs1005277 0.683 rs7923868 chr10:37989766 T/C cg25427524 chr10:38739819 LOC399744 -0.61 -10.25 -0.49 1.28e-21 Extrinsic epigenetic age acceleration; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg07157834 chr1:205819609 PM20D1 0.84 15.62 0.65 1.15e-41 Menarche (age at onset); LUSC cis rs4900538 0.927 rs8005804 chr14:102957803 A/G cg18135206 chr14:102964638 TECPR2 1.05 23.09 0.78 3.61e-71 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3020736 0.500 rs5996110 chr22:42493767 A/G cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06090383 chr4:174292579 SAP30 -0.52 -6.3 -0.33 9.28e-10 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg18876405 chr7:65276391 NA -0.54 -8.61 -0.43 2.89e-16 Aortic root size; LUSC cis rs4970988 0.607 rs7548516 chr1:150980281 C/T cg04414720 chr1:150670196 GOLPH3L -0.46 -6.66 -0.34 1.14e-10 Urate levels; LUSC trans rs1133146 1.000 rs1133146 chr19:53666660 A/G cg20908785 chr14:54863471 CDKN3 -0.37 -5.96 -0.31 6.28e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC cis rs2721195 0.549 rs2620666 chr8:145703413 T/C cg11211951 chr8:145729740 GPT 0.59 11.26 0.52 3.89e-25 Age at first birth; LUSC cis rs7799006 0.929 rs71525363 chr7:2268792 G/A cg02951883 chr7:2050386 MAD1L1 -0.37 -6.18 -0.32 1.87e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3733585 0.631 rs4697707 chr4:10119787 G/T cg11266682 chr4:10021025 SLC2A9 -0.5 -8.58 -0.42 3.63e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs10435719 0.764 rs10103485 chr8:11787563 C/T cg06636001 chr8:8085503 FLJ10661 0.54 8.19 0.41 5.57e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7727544 0.606 rs17622208 chr5:131717050 G/A cg24060327 chr5:131705240 SLC22A5 -0.41 -6.52 -0.34 2.57e-10 Blood metabolite levels; LUSC cis rs34779708 0.897 rs16935880 chr10:35415468 C/G cg04310649 chr10:35416472 CREM -0.43 -6.65 -0.34 1.23e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3750965 1.000 rs61881024 chr11:68837794 A/G cg06818126 chr11:68850279 TPCN2 -0.44 -6.31 -0.33 8.83e-10 Hair color; LUSC cis rs2242116 0.796 rs4587 chr3:46963502 T/C cg27129171 chr3:47204927 SETD2 0.57 8.15 0.41 7.2e-15 Birth weight; LUSC cis rs4073582 0.595 rs801731 chr11:65938446 G/C cg16950941 chr11:66035639 RAB1B 0.49 7.14 0.36 5.82e-12 Gout; LUSC cis rs7809950 0.815 rs62482495 chr7:106965009 A/G cg23024343 chr7:107201750 COG5 -0.66 -9.86 -0.47 2.6e-20 Coronary artery disease; LUSC cis rs10876993 0.821 rs1629032 chr12:58038686 C/T cg18357645 chr12:58087776 OS9 0.5 7.42 0.38 9.78e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg24829409 chr8:58192753 C8orf71 -0.59 -7.63 -0.39 2.43e-13 Developmental language disorder (linguistic errors); LUSC cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.58 -9.01 -0.44 1.59e-17 Menarche (age at onset); LUSC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg22963979 chr7:1858916 MAD1L1 -0.58 -9.17 -0.45 4.96e-18 Bipolar disorder and schizophrenia; LUSC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.68 -10.38 -0.49 4.67e-22 Monocyte percentage of white cells; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.86 -0.58 5.14e-31 Alzheimer's disease; LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -8.92 -0.44 3.1e-17 Bipolar disorder and schizophrenia; LUSC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg16262614 chr3:133464971 TF 0.41 7.15 0.36 5.56e-12 Iron status biomarkers (transferrin levels); LUSC cis rs28735056 0.592 rs10853392 chr18:77708781 A/G cg20368463 chr18:77673604 PQLC1 -0.59 -9.26 -0.45 2.52e-18 Schizophrenia; LUSC cis rs1577917 0.655 rs6454472 chr6:86224053 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 5.72 0.3 2.36e-8 Response to antipsychotic treatment; LUSC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg06238570 chr21:40685208 BRWD1 0.45 6.93 0.35 2.15e-11 Cognitive function; LUSC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.83 10.74 0.51 2.65e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11088226 0.645 rs2409457 chr21:33929895 T/C cg09050820 chr6:167586206 TCP10L2 0.75 9.74 0.47 6.57e-20 Gastritis; LUSC cis rs11583043 0.546 rs35363849 chr1:101591293 A/G cg11406453 chr1:101602562 NA -0.41 -6.81 -0.35 4.42e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7568458 0.870 rs6733913 chr2:85757379 T/C cg17127132 chr2:85788382 GGCX 0.47 7.66 0.39 1.99e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7241530 0.662 rs34015835 chr18:75905509 A/C cg14642773 chr18:75888474 NA 0.39 5.97 0.31 5.98e-9 Educational attainment (years of education); LUSC cis rs11971779 0.941 rs4732368 chr7:139034207 A/C cg07862535 chr7:139043722 LUC7L2 0.73 8.2 0.41 5.39e-15 Diisocyanate-induced asthma; LUSC cis rs2204008 0.580 rs36118148 chr12:38411812 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.54 -0.34 2.28e-10 Bladder cancer; LUSC cis rs4776059 1.000 rs3751614 chr15:52901638 T/C cg22715398 chr15:52968154 KIAA1370 -0.67 -9.97 -0.48 1.18e-20 Schizophrenia; LUSC cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg18357645 chr12:58087776 OS9 -0.43 -5.9 -0.31 8.78e-9 Multiple sclerosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16080015 chr7:5085479 RBAK 0.52 7.27 0.37 2.53e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs17253792 0.822 rs75991559 chr14:56092419 A/T cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs765787 0.530 rs1706831 chr15:45516230 T/C cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.44e-17 Uric acid levels; LUSC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg22496380 chr5:211416 CCDC127 -0.72 -8.41 -0.42 1.24e-15 Breast cancer; LUSC cis rs1568889 1.000 rs11604085 chr11:28141002 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.6 8.66 0.43 2.08e-16 Bipolar disorder; LUSC cis rs703842 1.000 rs11172351 chr12:58213485 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.51 6.97 0.36 1.71e-11 Multiple sclerosis; LUSC cis rs12579753 1.000 rs12811607 chr12:82233619 T/G cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.51 0.53 4.85e-26 Menopause (age at onset); LUSC cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.32 -0.37 1.82e-12 Menopause (age at onset); LUSC cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg07741184 chr6:167504864 NA 0.42 7.56 0.38 3.9e-13 Crohn's disease; LUSC cis rs8114671 0.869 rs1407202 chr20:33651967 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -5.71 -0.3 2.53e-8 Height; LUSC trans rs6502050 0.805 rs8082653 chr17:80162382 G/A cg07393940 chr7:158741817 NA 0.36 6.55 0.34 2.13e-10 Life satisfaction; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 14.09 0.61 1.09e-35 Platelet count; LUSC cis rs1577917 0.876 rs1582126 chr6:86697205 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.67 -0.34 1.07e-10 Response to antipsychotic treatment; LUSC cis rs8038465 0.622 rs56712926 chr15:73886849 G/T cg15420318 chr15:73925796 NPTN 0.56 9.5 0.46 4.23e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.57 -8.7 -0.43 1.58e-16 Lymphocyte counts; LUSC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.51 -7.81 -0.39 7.59e-14 Personality dimensions; LUSC cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg26384229 chr12:38710491 ALG10B -0.63 -9.83 -0.47 3.36e-20 Morning vs. evening chronotype; LUSC cis rs7819412 1.000 rs2409722 chr8:11039816 T/G cg21775007 chr8:11205619 TDH -0.52 -7.48 -0.38 6.58e-13 Triglycerides; LUSC cis rs752010 0.523 rs943376 chr1:42122117 A/G cg06885757 chr1:42089581 HIVEP3 0.5 10.29 0.49 9.67e-22 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg22467129 chr15:76604101 ETFA 0.44 7.15 0.36 5.51e-12 Blood metabolite levels; LUSC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 11.69 0.54 1.09e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs5769765 0.908 rs56351880 chr22:50316597 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.81 -10.32 -0.49 7.61e-22 Schizophrenia; LUSC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg03233332 chr7:66118400 NA 0.42 6.08 0.32 3.22e-9 Aortic root size; LUSC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg23719950 chr11:63933701 MACROD1 -0.6 -7.9 -0.4 4.11e-14 Mean platelet volume; LUSC cis rs62458065 1.000 rs79538247 chr7:32467792 A/G cg20159608 chr7:32802032 NA -0.56 -6.8 -0.35 4.97e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9341808 0.528 rs2322753 chr6:81042865 C/G cg08355045 chr6:80787529 NA 0.46 8.04 0.4 1.53e-14 Sitting height ratio; LUSC cis rs35079168 0.661 rs3118529 chr9:137304915 C/T cg24164254 chr9:137329341 RXRA -0.38 -6.14 -0.32 2.36e-9 Intelligence; LUSC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg19748678 chr4:122722346 EXOSC9 0.62 9.49 0.46 4.65e-19 Type 2 diabetes; LUSC cis rs644799 0.526 rs568120 chr11:95578734 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.6 9.09 0.45 9.27e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12950390 0.853 rs12451815 chr17:45855956 A/G cg03474202 chr17:45855739 NA -0.3 -6.95 -0.36 1.91e-11 IgG glycosylation; LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg14829155 chr15:31115871 NA -0.72 -10.66 -0.5 5.02e-23 Huntington's disease progression; LUSC trans rs4332037 1.000 rs6947019 chr7:1950337 G/A cg25206134 chr2:45395956 NA 0.56 6.45 0.33 3.98e-10 Bipolar disorder; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03300291 chr11:82868085 PCF11 0.37 6.08 0.32 3.36e-9 Asthma; LUSC cis rs6138458 1.000 rs227631 chr20:24913653 A/G cg06937882 chr20:24974362 C20orf3 -0.43 -7.41 -0.38 1.04e-12 Blood protein levels; LUSC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08109568 chr15:31115862 NA -0.61 -9.0 -0.44 1.75e-17 Huntington's disease progression; LUSC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg06238570 chr21:40685208 BRWD1 -0.56 -8.91 -0.44 3.33e-17 Menarche (age at onset); LUSC cis rs561341 0.663 rs72821936 chr17:30224068 C/G cg00745463 chr17:30367425 LRRC37B -0.45 -6.29 -0.33 1.01e-9 Hip circumference adjusted for BMI; LUSC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.86e-13 Depression; LUSC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.02 0.4 1.76e-14 Parkinson's disease; LUSC trans rs1973993 0.691 rs553785 chr1:96895325 G/A cg10631902 chr5:14652156 NA 0.62 11.08 0.52 1.61e-24 Weight; LUSC cis rs28595532 0.800 rs111626798 chr4:119352517 C/T cg21605333 chr4:119757512 SEC24D 1.02 8.32 0.41 2.28e-15 Cannabis dependence symptom count; LUSC cis rs1044826 1.000 rs17336869 chr3:139194247 T/C cg00490450 chr3:139108681 COPB2 0.52 6.78 0.35 5.37e-11 Obesity-related traits; LUSC cis rs35883536 0.609 rs2647327 chr1:101041766 C/T cg06223162 chr1:101003688 GPR88 0.47 9.12 0.45 7.41e-18 Monocyte count; LUSC trans rs800082 0.516 rs12486882 chr3:144228481 A/G cg24215973 chr2:240111563 HDAC4 0.45 6.85 0.35 3.61e-11 Smoking behavior; LUSC cis rs2970818 0.831 rs10849085 chr12:4644879 C/T cg11146114 chr12:4671731 NA -0.59 -5.88 -0.31 1.01e-8 Phosphorus levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12084011 chr7:107220368 BCAP29 0.4 6.09 0.32 3.11e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg24562669 chr7:97807699 LMTK2 0.34 5.91 0.31 8.4e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4478858 0.698 rs10914370 chr1:31854955 T/C cg00250761 chr1:31883323 NA -0.36 -8.55 -0.42 4.65e-16 Alcohol dependence; LUSC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg22963979 chr7:1858916 MAD1L1 -0.55 -8.33 -0.41 2.15e-15 Schizophrenia; LUSC cis rs11190604 1.000 rs10883509 chr10:102296461 C/T cg07080220 chr10:102295463 HIF1AN 0.69 9.46 0.46 5.64e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg03433033 chr1:76189801 ACADM 0.79 11.24 0.52 4.54e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9303401 0.659 rs56162835 chr17:56687315 A/G cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg02782426 chr3:40428986 ENTPD3 -0.33 -6.43 -0.33 4.44e-10 Renal cell carcinoma; LUSC trans rs561341 1.000 rs530209 chr17:30315287 A/G cg27661571 chr11:113659931 NA -0.69 -7.91 -0.4 3.77e-14 Hip circumference adjusted for BMI; LUSC cis rs7586879 0.765 rs6545758 chr2:25074874 C/T cg01884057 chr2:25150051 NA -0.35 -7.11 -0.36 6.87e-12 Body mass index; LUSC cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.45 -0.42 8.99e-16 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23328329 chr17:20059227 CYTSB 0.49 6.83 0.35 4.01e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs41271473 0.898 rs17352535 chr1:228822284 C/G cg16512390 chr1:228756714 NA 0.55 6.53 0.34 2.42e-10 Chronic lymphocytic leukemia; LUSC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg00106254 chr7:1943704 MAD1L1 -0.41 -5.89 -0.31 9.36e-9 Bipolar disorder and schizophrenia; LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg07806771 chr7:64541737 NA 0.42 6.05 0.31 3.89e-9 Calcium levels; LUSC cis rs1577917 0.916 rs4142546 chr6:86505311 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.78 -0.35 5.41e-11 Response to antipsychotic treatment; LUSC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg02569458 chr12:86230093 RASSF9 0.6 9.85 0.47 2.84e-20 Major depressive disorder; LUSC cis rs870825 0.616 rs28582728 chr4:185646920 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs13385 0.769 rs13359060 chr5:139605202 C/T cg26211634 chr5:139558579 C5orf32 0.45 6.75 0.35 6.51e-11 Atrial fibrillation; LUSC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg26597838 chr10:835615 NA 0.98 14.03 0.61 1.75e-35 Eosinophil percentage of granulocytes; LUSC trans rs7916697 0.626 rs3858145 chr10:70011838 A/G cg04882175 chr6:131122610 NA -0.52 -6.88 -0.35 2.96e-11 Optic disc area; LUSC cis rs11792861 0.589 rs2176692 chr9:111927723 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.54 7.86 0.4 5.29e-14 Menarche (age at onset); LUSC cis rs2274273 0.934 rs10139337 chr14:55742113 C/T cg04306507 chr14:55594613 LGALS3 0.55 12.14 0.55 2.37e-28 Protein biomarker; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg08206623 chr11:2907334 CDKN1C 0.36 6.27 0.32 1.1e-9 Calcium levels; LUSC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg03929089 chr4:120376271 NA -0.77 -12.23 -0.56 1.14e-28 Height; LUSC cis rs748404 0.697 rs531910 chr15:43560607 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.75 0.3 2.04e-8 Lung cancer; LUSC trans rs9929218 1.000 rs8045022 chr16:68807087 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -11.75 -0.54 6.51e-27 Colorectal cancer; LUSC trans rs61931739 0.963 rs59195137 chr12:34091838 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.84 -0.39 6.12e-14 Morning vs. evening chronotype; LUSC cis rs66887589 0.616 rs11731675 chr4:120212514 T/C cg24375607 chr4:120327624 NA 0.49 7.53 0.38 4.8e-13 Diastolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05565475 chr9:136223383 SURF2;SURF1 -0.43 -6.65 -0.34 1.22e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1801251 1.000 rs35212961 chr2:233582762 C/T cg25237894 chr2:233734115 C2orf82 0.35 6.55 0.34 2.22e-10 Coronary artery disease; LUSC cis rs8078723 0.763 rs4433838 chr17:38143532 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.46 7.52 0.38 5.02e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg04944784 chr2:26401820 FAM59B 0.63 8.11 0.41 9.46e-15 Gut microbiome composition (summer); LUSC cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg05347473 chr6:146136440 FBXO30 0.46 7.89 0.4 4.48e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs897080 0.552 rs698793 chr2:44685685 C/T cg00619915 chr2:44497795 NA -0.43 -6.16 -0.32 2.08e-9 Height; LUSC cis rs9807989 0.811 rs4485585 chr2:102970759 T/C cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs4888262 0.545 rs7342732 chr16:74698716 A/C cg01733217 chr16:74700730 RFWD3 0.78 13.23 0.59 2.08e-32 Testicular germ cell tumor; LUSC cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg05340658 chr4:99064831 C4orf37 0.57 9.54 0.46 3.03e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg07167872 chr1:205819463 PM20D1 0.82 14.84 0.63 1.28e-38 Menarche (age at onset); LUSC cis rs8114671 0.570 rs3761144 chr20:33544075 C/G cg24642439 chr20:33292090 TP53INP2 0.44 6.33 0.33 8.09e-10 Height; LUSC cis rs9399401 0.696 rs174441 chr6:142824299 G/A cg03128060 chr6:142623767 GPR126 0.31 5.7 0.3 2.58e-8 Chronic obstructive pulmonary disease; LUSC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg11752832 chr7:134001865 SLC35B4 -0.53 -8.14 -0.41 7.84e-15 Mean platelet volume; LUSC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg23791538 chr6:167370224 RNASET2 0.41 6.7 0.34 8.84e-11 Crohn's disease; LUSC cis rs9325144 0.872 rs11183390 chr12:38729942 G/T cg26384229 chr12:38710491 ALG10B -0.48 -7.13 -0.36 6.43e-12 Morning vs. evening chronotype; LUSC trans rs561341 1.000 rs564714 chr17:30318404 C/T cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg05347473 chr6:146136440 FBXO30 0.55 9.73 0.47 7.59e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg05855489 chr10:104503620 C10orf26 0.54 8.27 0.41 3.14e-15 Arsenic metabolism; LUSC trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.3 -0.45 1.93e-18 Extrinsic epigenetic age acceleration; LUSC cis rs9788721 1.000 rs931794 chr15:78826180 G/A cg18825076 chr15:78729989 IREB2 0.51 8.03 0.4 1.67e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs1949733 0.523 rs4619877 chr4:8543235 G/A cg13073564 chr4:8508604 NA 0.36 6.6 0.34 1.59e-10 Response to antineoplastic agents; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg14668821 chr17:77704760 ENPP7 0.29 6.01 0.31 4.95e-9 Menopause (age at onset); LUSC cis rs11051970 0.918 rs73084101 chr12:32544339 A/C cg02745156 chr12:32552066 NA 0.43 6.82 0.35 4.29e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9287719 0.901 rs10210859 chr2:10733929 C/T cg03983476 chr2:10830698 NOL10 -0.38 -5.71 -0.3 2.54e-8 Prostate cancer; LUSC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg20744362 chr22:50050164 C22orf34 0.38 7.82 0.39 6.8e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9467711 0.790 rs72843784 chr6:26498758 G/T cg09904177 chr6:26538194 HMGN4 -0.84 -5.96 -0.31 6.39e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg04166393 chr7:2884313 GNA12 0.44 5.69 0.3 2.76e-8 Height; LUSC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs11105298 0.685 rs117578503 chr12:89836672 G/C cg00757033 chr12:89920650 WDR51B 0.59 10.19 0.49 2.14e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6693567 0.565 rs6684939 chr1:150440563 G/A cg15654264 chr1:150340011 RPRD2 -0.46 -7.46 -0.38 7.73e-13 Migraine; LUSC cis rs1949733 0.666 rs3103070 chr4:8508825 A/G cg13073564 chr4:8508604 NA 0.48 8.93 0.44 2.94e-17 Response to antineoplastic agents; LUSC cis rs1008375 1.000 rs10939744 chr4:17664473 G/T cg15017067 chr4:17643749 FAM184B 0.35 5.69 0.3 2.71e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7216064 1.000 rs1976053 chr17:65833002 C/G cg12091567 chr17:66097778 LOC651250 -0.73 -9.74 -0.47 6.71e-20 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7829975 0.623 rs7010753 chr8:8373956 A/G cg08975724 chr8:8085496 FLJ10661 0.47 6.99 0.36 1.5e-11 Mood instability; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25621393 chr5:149737060 TCOF1 0.39 5.95 0.31 6.8e-9 Mosquito bite size; LUSC cis rs3820068 0.577 rs41270271 chr1:15913582 G/C cg17385448 chr1:15911702 AGMAT 0.37 5.95 0.31 6.81e-9 Systolic blood pressure; LUSC cis rs77505915 0.512 rs12921808 chr16:75383984 T/C cg07303275 chr16:75499416 TMEM170A -0.44 -5.77 -0.3 1.82e-8 Migraine; LUSC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg03676636 chr4:99064102 C4orf37 0.32 6.99 0.36 1.48e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg20849893 chr7:64541193 NA 0.47 6.77 0.35 5.8200000000000003e-11 Calcium levels; LUSC trans rs8072100 0.875 rs4794047 chr17:45763005 A/T cg03886242 chr7:26192032 NFE2L3 0.39 6.55 0.34 2.22e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg25817165 chr18:72167213 CNDP2 -0.75 -11.17 -0.52 8.07e-25 Refractive error; LUSC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg15212455 chr7:39170539 POU6F2 0.68 11.64 0.54 1.63e-26 IgG glycosylation; LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg16325326 chr1:53192061 ZYG11B -0.7 -10.88 -0.51 8.17e-24 Monocyte count; LUSC cis rs7523273 0.606 rs2724388 chr1:207933577 T/G cg22525895 chr1:207977042 MIR29B2 0.41 6.61 0.34 1.48e-10 Schizophrenia; LUSC cis rs9648716 0.515 rs2688430 chr7:140728682 T/C cg23214464 chr7:140373596 ADCK2 -0.72 -6.24 -0.32 1.34e-9 Type 2 diabetes; LUSC cis rs2108225 0.872 rs7792139 chr7:107445433 G/A cg18560240 chr7:107437656 SLC26A3 -0.45 -6.71 -0.34 8.26e-11 Ulcerative colitis; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg22907277 chr7:1156413 C7orf50 0.47 7.14 0.36 5.91e-12 Longevity;Endometriosis; LUSC cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -11.76 -0.54 5.79e-27 Systemic lupus erythematosus; LUSC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg05738196 chr6:26577821 NA -0.56 -6.9 -0.35 2.58e-11 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.744 rs10929234 chr2:238380034 C/G cg14458575 chr2:238380390 NA -0.85 -14.73 -0.63 3.44e-38 Prostate cancer; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg00166722 chr3:10149974 C3orf24 0.54 7.55 0.38 4.16e-13 Alzheimer's disease; LUSC cis rs7712401 0.601 rs30060 chr5:122296700 T/C cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs920590 0.758 rs35896770 chr8:19665616 G/C cg03894339 chr8:19674705 INTS10 0.53 7.05 0.36 1.04e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg07936489 chr17:37558343 FBXL20 0.72 10.05 0.48 5.95e-21 Glomerular filtration rate (creatinine); LUSC cis rs1003719 0.788 rs2835584 chr21:38460338 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.66 10.82 0.51 1.39e-23 Eye color traits; LUSC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg03233332 chr7:66118400 NA -0.42 -5.99 -0.31 5.55e-9 Aortic root size; LUSC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs2204008 0.571 rs1117803 chr12:38281007 C/G cg26384229 chr12:38710491 ALG10B -0.57 -8.6 -0.43 3.1e-16 Bladder cancer; LUSC cis rs12134245 0.874 rs17501937 chr1:92021705 C/T cg02896835 chr1:92012615 NA 0.53 9.06 0.44 1.14e-17 Breast cancer; LUSC cis rs4268898 0.662 rs17789375 chr2:24502554 G/T cg06627628 chr2:24431161 ITSN2 -0.86 -12.77 -0.57 1.12e-30 Asthma; LUSC cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00345343 chr16:89422185 ANKRD11 0.45 6.25 0.32 1.22e-9 Bipolar disorder and schizophrenia; LUSC cis rs2599510 0.703 rs762023 chr2:32713170 G/A cg02381751 chr2:32503542 YIPF4 0.4 5.95 0.31 6.76e-9 Interleukin-18 levels; LUSC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs7582180 0.629 rs11123827 chr2:100951248 C/G cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs3540 0.533 rs1869179 chr15:90895564 A/C cg10434728 chr15:90938212 IQGAP1 0.39 7.96 0.4 2.74e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7560272 0.538 rs1806683 chr2:73939812 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -6.83 -0.35 4.15e-11 Schizophrenia; LUSC cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg11645453 chr3:52864694 ITIH4 0.51 11.11 0.52 1.26e-24 Schizophrenia; LUSC trans rs7726839 0.574 rs12522955 chr5:639231 C/A cg25482853 chr8:67687455 SGK3 1.11 15.36 0.64 1.15e-40 Obesity-related traits; LUSC cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg23260525 chr10:116636907 FAM160B1 0.49 10.57 0.5 1.05e-22 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4474465 0.850 rs10793324 chr11:78251485 C/T cg27205649 chr11:78285834 NARS2 -0.54 -6.66 -0.34 1.13e-10 Alzheimer's disease (survival time); LUSC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg13319975 chr6:146136371 FBXO30 -0.7 -11.15 -0.52 8.96e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs701145 0.878 rs187357 chr3:153958876 C/A cg17054900 chr3:154042577 DHX36 0.85 9.0 0.44 1.75e-17 Coronary artery disease; LUSC cis rs9549260 0.816 rs7337995 chr13:41249040 A/G cg21288729 chr13:41239152 FOXO1 0.58 8.69 0.43 1.65e-16 Red blood cell count; LUSC cis rs12421382 0.593 rs1808842 chr11:109389454 C/T cg16359550 chr11:109292809 C11orf87 0.34 5.99 0.31 5.43e-9 Schizophrenia; LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg26668828 chr6:292823 DUSP22 0.49 7.48 0.38 6.7e-13 Menopause (age at onset); LUSC trans rs61931739 0.500 rs11053272 chr12:34547020 C/G cg13010199 chr12:38710504 ALG10B 0.68 10.55 0.5 1.16e-22 Morning vs. evening chronotype; LUSC trans rs1997103 1.000 rs2009441 chr7:55405989 A/G cg20935933 chr6:143382018 AIG1 0.5 7.27 0.37 2.61e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs656319 0.674 rs1484639 chr8:9983224 T/G cg15556689 chr8:8085844 FLJ10661 0.54 7.96 0.4 2.74e-14 Myopia (pathological); LUSC trans rs3733585 0.699 rs60045583 chr4:9971950 G/A cg26043149 chr18:55253948 FECH -0.45 -6.78 -0.35 5.62e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.08 0.44 1e-17 Tonsillectomy; LUSC cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg13736514 chr6:26305472 NA -0.47 -9.18 -0.45 4.48e-18 Educational attainment; LUSC cis rs9788682 0.747 rs2656073 chr15:78742276 G/T cg18825076 chr15:78729989 IREB2 0.45 6.36 0.33 6.6e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs5769707 0.632 rs6009782 chr22:50010812 C/G cg20744362 chr22:50050164 C22orf34 0.38 7.04 0.36 1.12e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg08747591 chr11:789928 CEND1 0.41 6.94 0.35 2.05e-11 Breast cancer; LUSC cis rs6732160 0.650 rs7560224 chr2:73406182 A/G cg24220031 chr2:73402428 NA -0.23 -5.73 -0.3 2.27e-8 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.562 rs7263157 chr20:33459127 G/A cg24642439 chr20:33292090 TP53INP2 0.45 6.36 0.33 6.73e-10 Height; LUSC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg15352829 chr14:105391018 PLD4 -0.42 -8.89 -0.44 3.84e-17 Rheumatoid arthritis; LUSC cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.28 0.49 9.91e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs11586313 0.571 rs11583382 chr1:152874096 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.8 -0.3 1.58e-8 Vitamin D levels; LUSC trans rs7726839 0.561 rs11955068 chr5:582324 C/T cg25482853 chr8:67687455 SGK3 1.03 15.45 0.65 5.41e-41 Obesity-related traits; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02522757 chr12:48298992 VDR 0.37 6.61 0.34 1.49e-10 Triglycerides; LUSC cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg23625390 chr15:77176239 SCAPER 0.51 8.01 0.4 1.91e-14 Blood metabolite levels; LUSC cis rs68170813 0.652 rs11532774 chr7:107201579 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.46 -5.72 -0.3 2.4e-8 Coronary artery disease; LUSC cis rs208520 0.661 rs207111 chr6:66792513 C/T cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg20887711 chr4:1340912 KIAA1530 0.53 8.08 0.4 1.19e-14 Obesity-related traits; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg24503407 chr1:205819492 PM20D1 0.84 14.77 0.63 2.3e-38 Menarche (age at onset); LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg04518342 chr5:131593106 PDLIM4 0.5 8.99 0.44 1.83e-17 Acylcarnitine levels; LUSC cis rs11190604 1.000 rs7477246 chr10:102261538 C/T cg23241863 chr10:102295624 HIF1AN 0.5 6.08 0.32 3.24e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11098499 0.774 rs11098505 chr4:120284627 C/T cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs10097731 0.901 rs10464891 chr8:82042900 C/A cg25230327 chr8:82042993 NA -0.48 -6.78 -0.35 5.55e-11 Serum total protein level; LUSC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg10802521 chr3:52805072 NEK4 -0.5 -8.15 -0.41 7.33e-15 Bipolar disorder; LUSC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg07701084 chr6:150067640 NUP43 0.56 8.74 0.43 1.15e-16 Lung cancer; LUSC cis rs7786808 0.712 rs12671981 chr7:158202971 G/A cg01191920 chr7:158217561 PTPRN2 -0.5 -10.11 -0.48 3.72e-21 Obesity-related traits; LUSC cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B -0.54 -9.03 -0.44 1.42e-17 IgG glycosylation; LUSC cis rs2486288 0.656 rs8040185 chr15:45552081 G/A cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.67 -0.5 4.42e-23 Glomerular filtration rate; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05237023 chr16:75182837 ZFP1 -0.46 -6.1 -0.32 2.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs16854884 1.000 rs35887108 chr3:143780632 C/T cg06585982 chr3:143692056 C3orf58 0.46 6.43 0.33 4.42e-10 Economic and political preferences (feminism/equality); LUSC cis rs7184046 0.797 rs13737 chr15:75932129 G/T cg20655648 chr15:75932815 IMP3 0.44 5.87 0.31 1.06e-8 Height; LUSC cis rs11098499 0.863 rs58452170 chr4:120459674 A/T cg09307838 chr4:120376055 NA 0.74 10.53 0.5 1.36e-22 Corneal astigmatism; LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg05552183 chr6:42928497 GNMT 0.54 9.0 0.44 1.75e-17 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4919694 1.000 rs11191545 chr10:104829793 C/T cg04362960 chr10:104952993 NT5C2 1.12 14.37 0.62 8.44e-37 Arsenic metabolism; LUSC cis rs7940866 0.834 rs2324315 chr11:130839772 C/G cg12179176 chr11:130786555 SNX19 0.58 8.67 0.43 1.85e-16 Schizophrenia; LUSC cis rs6426558 0.537 rs648877 chr1:227283614 A/G cg10327440 chr1:227177885 CDC42BPA 0.54 7.34 0.37 1.62e-12 Neutrophil percentage of white cells; LUSC trans rs4332037 0.826 rs4721188 chr7:1953615 G/A cg11693508 chr17:37793320 STARD3 -0.54 -6.87 -0.35 3.21e-11 Bipolar disorder; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg07362569 chr17:61921086 SMARCD2 -0.37 -7.56 -0.38 3.94e-13 Prudent dietary pattern; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05654711 chr1:85930865 DDAH1 0.75 5.99 0.31 5.35e-9 Cognitive performance; LUSC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg22920501 chr2:26401640 FAM59B 0.77 10.82 0.51 1.34e-23 Gut microbiome composition (summer); LUSC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.31e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg00815214 chr21:47717953 NA -0.35 -5.7 -0.3 2.6e-8 Testicular germ cell tumor; LUSC cis rs10761482 1.000 rs1350631 chr10:62082569 T/A cg18175470 chr10:62150864 ANK3 -0.48 -6.62 -0.34 1.41e-10 Schizophrenia; LUSC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg07936489 chr17:37558343 FBXL20 -0.72 -10.04 -0.48 6.81e-21 Glomerular filtration rate (creatinine); LUSC cis rs453301 0.624 rs2288671 chr8:8860894 T/C cg15556689 chr8:8085844 FLJ10661 0.69 11.03 0.52 2.52e-24 Joint mobility (Beighton score); LUSC trans rs9393777 0.920 rs35716472 chr6:27406607 C/G cg01620082 chr3:125678407 NA -0.7 -6.75 -0.35 6.57e-11 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg01579765 chr21:45077557 HSF2BP -0.49 -10.24 -0.49 1.36e-21 Mean corpuscular volume; LUSC cis rs2806561 0.780 rs12117752 chr1:23360223 T/C cg19743168 chr1:23544995 NA -0.44 -9.02 -0.44 1.5e-17 Height; LUSC trans rs561341 0.941 rs4625780 chr17:30249214 A/C cg27661571 chr11:113659931 NA -0.57 -6.48 -0.33 3.25e-10 Hip circumference adjusted for BMI; LUSC trans rs62238980 0.614 rs117721418 chr22:32394519 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.02 -0.31 4.68e-9 Childhood ear infection; LUSC cis rs2562456 0.917 rs2650825 chr19:21699225 A/G cg00806126 chr19:22604979 ZNF98 -0.4 -6.06 -0.31 3.61e-9 Pain; LUSC cis rs6084875 0.840 rs1999664 chr20:4721148 C/T cg26097573 chr20:4721490 PRNT -0.31 -5.74 -0.3 2.1e-8 Systemic lupus erythematosus; LUSC cis rs250677 0.687 rs250673 chr5:148445798 C/T cg23229984 chr5:148520753 ABLIM3 0.41 6.48 0.33 3.22e-10 Breast cancer; LUSC cis rs394563 0.601 rs367133 chr6:149797720 T/G cg07828024 chr6:149772892 ZC3H12D -0.34 -6.95 -0.36 1.91e-11 Dupuytren's disease; LUSC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg27398817 chr8:82754497 SNX16 0.44 5.95 0.31 6.79e-9 Diastolic blood pressure; LUSC cis rs8060686 0.641 rs73598006 chr16:68074454 C/G cg05110241 chr16:68378359 PRMT7 -0.52 -6.18 -0.32 1.85e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg14440974 chr22:39074834 NA -0.35 -5.86 -0.31 1.1e-8 Menopause (age at onset); LUSC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg05855489 chr10:104503620 C10orf26 -0.64 -8.45 -0.42 9.23e-16 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.43 -5.93 -0.31 7.63e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs763121 0.962 rs909564 chr22:39126508 A/G cg06544989 chr22:39130855 UNC84B 0.34 6.02 0.31 4.58e-9 Menopause (age at onset); LUSC cis rs17540621 1.000 rs10194115 chr2:47240012 G/T cg23978866 chr2:47230407 TTC7A -0.76 -6.11 -0.32 2.83e-9 Response to statin therapy; LUSC cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg00631329 chr6:26305371 NA -0.47 -9.2 -0.45 3.84e-18 Educational attainment; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg00634984 chr7:65235879 NA 0.4 5.74 0.3 2.08e-8 Calcium levels; LUSC cis rs9921338 0.961 rs4780358 chr16:11374212 G/T cg00044050 chr16:11439710 C16orf75 -0.5 -6.93 -0.35 2.21e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg21280719 chr6:42927975 GNMT -0.3 -7.72 -0.39 1.41e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg26769984 chr7:1090371 C7orf50 0.48 5.76 0.3 1.86e-8 Bronchopulmonary dysplasia; LUSC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg24209194 chr3:40518798 ZNF619 0.47 6.37 0.33 6.32e-10 Renal cell carcinoma; LUSC cis rs4631830 0.720 rs113082846 chr10:51502802 G/C cg10326726 chr10:51549505 MSMB -0.36 -6.33 -0.33 7.98e-10 Prostate-specific antigen levels; LUSC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg10802521 chr3:52805072 NEK4 -0.53 -8.57 -0.42 3.89e-16 Bipolar disorder; LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg23173402 chr1:227635558 NA 0.59 7.23 0.37 3.41e-12 Major depressive disorder; LUSC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg26855724 chr1:75198818 TYW3;CRYZ -0.47 -6.76 -0.35 6.27e-11 Resistin levels; LUSC cis rs9400467 0.508 rs11153283 chr6:111597143 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.27 -0.32 1.11e-9 Blood metabolite levels;Amino acid levels; LUSC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg14456004 chr13:21872349 NA 0.43 6.02 0.31 4.68e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg26597838 chr10:835615 NA 0.8 9.93 0.48 1.6e-20 Eosinophil percentage of granulocytes; LUSC cis rs3126085 0.935 rs10888475 chr1:152226012 C/T cg03465714 chr1:152285911 FLG -0.4 -5.73 -0.3 2.25e-8 Atopic dermatitis; LUSC cis rs6599077 1.000 rs9842085 chr3:40095544 T/C cg13683864 chr3:40499215 RPL14 -0.6 -7.66 -0.39 2.06e-13 Sleep-related phenotypes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11698762 chr2:74648964 WDR54 0.44 6.02 0.31 4.65e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11650494 0.710 rs73987294 chr17:47474730 T/C cg08112188 chr17:47440006 ZNF652 0.93 7.93 0.4 3.3e-14 Prostate cancer; LUSC trans rs1945213 0.694 rs7106894 chr11:55877315 T/C cg15704280 chr7:45808275 SEPT13 0.75 8.49 0.42 7.09e-16 Acute lymphoblastic leukemia (childhood); LUSC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg04450456 chr4:17643702 FAM184B 0.39 6.6 0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg18252515 chr7:66147081 NA -1.22 -13.79 -0.6 1.47e-34 Diabetic kidney disease; LUSC cis rs73200209 0.744 rs1865787 chr12:116429689 A/G cg01776926 chr12:116560359 MED13L -0.49 -5.84 -0.3 1.26e-8 Total body bone mineral density; LUSC cis rs4423214 1.000 rs12791871 chr11:71164544 A/C cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs6942756 0.774 rs2566876 chr7:128890055 A/G cg02491457 chr7:128862824 NA 0.51 7.65 0.39 2.22e-13 White matter hyperintensity burden; LUSC cis rs4843185 0.669 rs889502 chr16:85716832 A/G cg26571870 chr16:85723150 GINS2 -0.33 -5.98 -0.31 5.71e-9 Platelet distribution width; LUSC trans rs7615952 0.576 rs66671308 chr3:125793526 T/G cg07211511 chr3:129823064 LOC729375 -0.74 -9.45 -0.46 6.14e-19 Blood pressure (smoking interaction); LUSC cis rs4443100 0.631 rs13054904 chr22:23410918 A/T cg21100191 chr22:23484243 RTDR1 -0.57 -7.24 -0.37 3.16e-12 Serum parathyroid hormone levels; LUSC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg26513180 chr16:89883248 FANCA 0.79 6.36 0.33 6.64e-10 Skin colour saturation; LUSC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg12311346 chr5:56204834 C5orf35 -0.83 -13.82 -0.6 1.19e-34 Initial pursuit acceleration; LUSC cis rs11608355 0.521 rs7978210 chr12:109835990 A/G cg19025524 chr12:109796872 NA -0.38 -7.14 -0.36 5.97e-12 Neuroticism; LUSC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg06618935 chr21:46677482 NA -0.39 -7.84 -0.39 6.1e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg25258033 chr6:167368657 RNASET2 0.39 6.36 0.33 6.72e-10 Crohn's disease; LUSC trans rs3960554 0.569 rs1894761 chr7:75876754 C/T cg19862616 chr7:65841803 NCRNA00174 -0.6 -7.56 -0.38 3.84e-13 Eotaxin levels; LUSC cis rs72634258 0.786 rs7514098 chr1:8177632 G/A cg26816564 chr1:7831052 VAMP3 0.43 5.66 0.3 3.24e-8 Inflammatory bowel disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13627451 chr15:52043674 TMOD2;LYSMD2 -0.46 -6.37 -0.33 6.32e-10 Bipolar disorder and schizophrenia; LUSC trans rs1325195 0.537 rs2636290 chr1:179096088 A/G cg11624085 chr17:8464688 MYH10 -0.43 -6.45 -0.33 3.96e-10 IgE grass sensitization; LUSC cis rs11711311 1.000 rs891574 chr3:113537639 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.69 -0.3 2.76e-8 IgG glycosylation; LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg18404041 chr3:52824283 ITIH1 -0.63 -12.28 -0.56 7.14e-29 Bipolar disorder; LUSC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.96e-13 Obesity-related traits; LUSC trans rs61931739 0.534 rs35056575 chr12:34142914 A/T cg26384229 chr12:38710491 ALG10B 0.73 11.8 0.54 4.28e-27 Morning vs. evening chronotype; LUSC cis rs1506636 0.962 rs1506640 chr7:123349627 T/G cg03229431 chr7:123269106 ASB15 -0.64 -10.38 -0.49 4.73e-22 Plateletcrit;Platelet count; LUSC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg19717773 chr7:2847554 GNA12 -0.39 -6.1 -0.32 2.87e-9 Height; LUSC cis rs7917772 0.582 rs3936017 chr10:104354424 T/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.42 -0.38 9.5e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.47 7.9 0.4 4.11e-14 Vitiligo; LUSC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg07636037 chr3:49044803 WDR6 1.07 18.33 0.71 1.96e-52 Parkinson's disease; LUSC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg17971929 chr21:40555470 PSMG1 -0.69 -11.44 -0.53 8.9e-26 Cognitive function; LUSC trans rs11039798 1.000 rs11039904 chr11:48682597 T/A cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.44e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00441741 chr2:172290573 DCAF17;METTL8 -0.43 -6.53 -0.34 2.39e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4588572 0.643 rs10474554 chr5:77799158 C/T cg11547950 chr5:77652471 NA -0.53 -7.41 -0.38 1.07e-12 Triglycerides; LUSC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg26597838 chr10:835615 NA 0.97 13.07 0.58 8.01e-32 Eosinophil percentage of granulocytes; LUSC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.41e-13 Bipolar disorder; LUSC cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg07148914 chr20:33460835 GGT7 -0.53 -8.18 -0.41 5.91e-15 Glomerular filtration rate (creatinine); LUSC cis rs12310956 0.532 rs7306007 chr12:33975209 C/G cg06521331 chr12:34319734 NA -0.47 -7.55 -0.38 4.27e-13 Morning vs. evening chronotype; LUSC trans rs208520 0.821 rs9363572 chr6:67012231 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 8.76 0.43 9.74e-17 Exhaled nitric oxide output; LUSC cis rs4921915 0.519 rs35583283 chr8:18254509 G/C cg18736775 chr8:18248649 NAT2 -0.59 -7.09 -0.36 8.13e-12 Iron status biomarkers (transferrin levels); LUSC cis rs55665837 1.000 rs12288873 chr11:14450465 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC trans rs9329221 0.905 rs28712068 chr8:10251145 G/C cg15556689 chr8:8085844 FLJ10661 -0.62 -9.43 -0.46 7.33e-19 Neuroticism; LUSC cis rs6066835 1.000 rs6066830 chr20:47353897 C/T cg18078177 chr20:47281410 PREX1 0.71 6.21 0.32 1.61e-9 Multiple myeloma; LUSC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg03433033 chr1:76189801 ACADM 0.72 9.47 0.46 5.43e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs62400317 0.731 rs12214435 chr6:44906717 G/A cg18551225 chr6:44695536 NA -0.48 -7.63 -0.39 2.53e-13 Total body bone mineral density; LUSC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg20607287 chr7:12443886 VWDE -0.59 -6.06 -0.31 3.74e-9 Coronary artery disease; LUSC cis rs10789491 1.000 rs2218191 chr1:47130628 C/T cg15501359 chr1:47185051 KIAA0494 0.65 8.94 0.44 2.63e-17 Response to hepatitis C treatment; LUSC cis rs6960043 0.875 rs2215382 chr7:15055010 C/G cg19272540 chr7:15055459 NA 0.35 8.89 0.44 3.86e-17 Type 2 diabetes; LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs11677370 0.533 rs12711971 chr2:3820821 G/C cg17052675 chr2:3827356 NA -0.65 -10.46 -0.5 2.41e-22 Type 2 diabetes; LUSC cis rs7772486 0.742 rs4896851 chr6:146278959 T/C cg23711669 chr6:146136114 FBXO30 -0.81 -13.84 -0.6 9.75e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg25258033 chr6:167368657 RNASET2 -0.47 -7.83 -0.39 6.38e-14 Crohn's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10088075 chr16:30407103 ZNF48 0.77 6.5 0.34 2.9e-10 Cognitive performance; LUSC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg23982607 chr1:1823379 GNB1 -0.73 -15.0 -0.63 2.94e-39 Body mass index; LUSC cis rs425277 0.958 rs626479 chr1:2110260 A/G cg03732007 chr1:2071316 PRKCZ -0.47 -7.75 -0.39 1.11e-13 Height; LUSC trans rs564343 0.545 rs2241303 chr11:65819661 C/A cg26701943 chr11:108369231 KDELC2 -0.47 -6.38 -0.33 5.81e-10 Obesity (early onset extreme); LUSC cis rs9790314 0.967 rs6762645 chr3:160948349 T/G cg03342759 chr3:160939853 NMD3 -0.5 -8.27 -0.41 3.24e-15 Morning vs. evening chronotype; LUSC trans rs17266958 1.000 rs62574523 chr9:83284859 C/G cg01905489 chr1:26616534 UBXN11 -0.52 -5.96 -0.31 6.31e-9 Preschool internalizing problems; LUSC cis rs9640161 0.830 rs11768108 chr7:150064150 C/T cg21361702 chr7:150065534 REPIN1 0.58 8.17 0.41 6.39e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs782590 0.748 rs782634 chr2:55897700 T/C cg03859395 chr2:55845619 SMEK2 0.76 13.0 0.58 1.51e-31 Metabolic syndrome; LUSC cis rs4654899 0.865 rs6685831 chr1:21507888 G/A cg02927042 chr1:21476669 EIF4G3 -0.36 -5.68 -0.3 2.92e-8 Superior frontal gyrus grey matter volume; LUSC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg08499158 chr17:42289980 UBTF -0.37 -6.0 -0.31 5.1e-9 Red cell distribution width;Reticulocyte count; LUSC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs3820928 0.874 rs116652884 chr2:227902285 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.89 -0.4 4.48e-14 Pulmonary function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13402217 chr1:151584375 SNX27 -0.37 -6.3 -0.33 9.6e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg10150615 chr22:24372951 LOC391322 0.42 7.02 0.36 1.23e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10100465 0.889 rs7838659 chr8:118684994 C/T cg09430518 chr8:118662568 NA -0.32 -5.94 -0.31 7.11e-9 Leprosy; LUSC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.42 -6.91 -0.35 2.41e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs472402 0.580 rs7720479 chr5:6640049 A/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.43 -6.34 -0.33 7.48e-10 Response to amphetamines; LUSC trans rs61931739 0.749 rs11053093 chr12:34231095 A/G cg13010199 chr12:38710504 ALG10B 0.39 6.25 0.32 1.23e-9 Morning vs. evening chronotype; LUSC cis rs262150 0.530 rs2730232 chr7:158784469 C/T cg19418458 chr7:158789849 NA 0.46 6.33 0.33 7.95e-10 Facial morphology (factor 20); LUSC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg12016809 chr21:47604291 C21orf56 0.39 5.66 0.3 3.33e-8 Testicular germ cell tumor; LUSC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg11632617 chr15:75315747 PPCDC -0.54 -6.97 -0.36 1.67e-11 Blood trace element (Zn levels); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20454520 chr14:24584429 DCAF11 -0.5 -6.16 -0.32 2.06e-9 Bipolar disorder and schizophrenia; LUSC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg21463023 chr3:42623862 SEC22C 0.44 5.99 0.31 5.3300000000000004e-09 Mosquito bite size; LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg03477792 chr4:77819574 ANKRD56 0.61 8.93 0.44 2.88e-17 Emphysema distribution in smoking; LUSC trans rs2243480 1.000 rs1404147 chr7:65264524 C/T cg10756647 chr7:56101905 PSPH 0.82 8.41 0.42 1.18e-15 Diabetic kidney disease; LUSC cis rs9303280 0.806 rs36095411 chr17:38031865 T/G cg19468946 chr17:37922297 IKZF3 -0.44 -6.79 -0.35 5.19e-11 Self-reported allergy; LUSC cis rs11190604 0.767 rs10786590 chr10:102164604 T/C cg07080220 chr10:102295463 HIF1AN 0.59 7.64 0.39 2.24e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs763121 0.962 rs5757135 chr22:38952573 C/T cg06544989 chr22:39130855 UNC84B 0.34 6.03 0.31 4.39e-9 Menopause (age at onset); LUSC cis rs9815354 1.000 rs1716987 chr3:41970516 A/G cg03022575 chr3:42003672 ULK4 -0.59 -6.52 -0.34 2.53e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg06108461 chr20:60628389 TAF4 0.68 8.81 0.43 7.02e-17 Obesity-related traits; LUSC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg11189052 chr15:85197271 WDR73 0.47 5.78 0.3 1.68e-8 Schizophrenia; LUSC cis rs9309473 0.500 rs4852308 chr2:73834035 T/G cg20560298 chr2:73613845 ALMS1 0.48 7.38 0.37 1.31e-12 Metabolite levels; LUSC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg10792982 chr14:105748885 BRF1 0.48 8.31 0.41 2.39e-15 Mean platelet volume;Platelet distribution width; LUSC trans rs2587949 0.593 rs1872415 chr3:4211374 A/G cg15139668 chr4:4577005 NA 0.41 6.08 0.32 3.23e-9 Periodontitis (DPAL); LUSC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg12639453 chr1:2035780 PRKCZ 0.33 7.21 0.37 3.74e-12 Height; LUSC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg12564285 chr5:131593104 PDLIM4 0.39 7.05 0.36 1.01e-11 Breast cancer; LUSC cis rs868036 0.718 rs28399056 chr15:68116010 C/A cg24579218 chr15:68104479 NA -0.39 -6.78 -0.35 5.61e-11 Restless legs syndrome; LUSC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg22535103 chr8:58192502 C8orf71 -0.79 -9.6 -0.46 2.04e-19 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.94 -0.31 7.27e-9 Life satisfaction; LUSC cis rs7095944 0.584 rs4962692 chr10:126424823 G/A cg08799069 chr10:126477246 METTL10 -0.4 -6.08 -0.32 3.26e-9 Asthma; LUSC cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg08999081 chr20:33150536 PIGU 0.37 6.84 0.35 3.71e-11 Height; LUSC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg21963583 chr11:68658836 MRPL21 0.53 8.16 0.41 6.72e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11871801 0.517 rs60929812 chr17:40759448 G/A cg16308533 chr17:40838983 CNTNAP1 0.39 5.76 0.3 1.89e-8 Crohn's disease; LUSC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg11062466 chr8:58055876 NA 0.47 6.44 0.33 4.09e-10 Developmental language disorder (linguistic errors); LUSC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg27572855 chr1:25598939 RHD -0.4 -7.06 -0.36 9.98e-12 Erythrocyte sedimentation rate; LUSC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg11247378 chr22:39784982 NA -0.59 -10.22 -0.49 1.62e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg02931644 chr1:25747376 RHCE 0.33 5.89 0.31 9.3e-9 Erythrocyte sedimentation rate; LUSC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg05973401 chr12:123451056 ABCB9 0.49 5.97 0.31 5.95e-9 Height;Educational attainment;Head circumference (infant); LUSC cis rs10504073 0.565 rs35282337 chr8:49920994 G/A cg00325661 chr8:49890786 NA 0.7 11.24 0.52 4.39e-25 Blood metabolite ratios; LUSC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg09509183 chr1:209979624 IRF6 0.48 5.78 0.3 1.71e-8 Cleft lip with or without cleft palate; LUSC trans rs3808502 0.585 rs4549730 chr8:11239078 T/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.64 -0.39 2.39e-13 Neuroticism; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg07167872 chr1:205819463 PM20D1 0.85 16.7 0.67 6.24e-46 Menarche (age at onset); LUSC cis rs11098499 0.569 rs55845118 chr4:120290913 T/C cg09307838 chr4:120376055 NA 0.69 10.35 0.49 5.71e-22 Corneal astigmatism; LUSC cis rs7131987 0.868 rs737160 chr12:29429012 T/C cg09582351 chr12:29534625 ERGIC2 -0.3 -6.19 -0.32 1.74e-9 QT interval; LUSC trans rs4332037 0.624 rs56256289 chr7:1892529 C/T cg10840412 chr1:235813424 GNG4 0.45 6.17 0.32 1.96e-9 Bipolar disorder; LUSC trans rs800082 0.734 rs1726536 chr3:144249504 G/T cg24215973 chr2:240111563 HDAC4 0.41 6.09 0.32 3.07e-9 Smoking behavior; LUSC cis rs17540621 1.000 rs114356926 chr2:47222236 G/T cg23978866 chr2:47230407 TTC7A -0.97 -6.65 -0.34 1.21e-10 Response to statin therapy; LUSC cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg21573476 chr21:45109991 RRP1B -0.38 -6.02 -0.31 4.48e-9 Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02668984 chr17:48172022 PDK2 0.43 6.35 0.33 7.22e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7617480 0.648 rs9284885 chr3:48883100 A/C cg07636037 chr3:49044803 WDR6 0.94 13.17 0.58 3.42e-32 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs6960043 1.000 rs6972516 chr7:15051789 G/T cg19272540 chr7:15055459 NA -0.29 -6.75 -0.35 6.51e-11 Type 2 diabetes; LUSC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg22535103 chr8:58192502 C8orf71 -0.85 -8.34 -0.42 1.95e-15 Developmental language disorder (linguistic errors); LUSC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC trans rs1728785 1.000 rs1728764 chr16:68572292 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs3020736 0.500 rs5996109 chr22:42493098 A/G cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.51 0.38 5.46e-13 Colorectal cancer; LUSC cis rs9287719 0.934 rs4629131 chr2:10744159 C/T cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs4727027 0.704 rs12704071 chr7:148904795 C/T cg23158103 chr7:148848205 ZNF398 -0.47 -7.88 -0.4 4.73e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg27532560 chr4:187881888 NA -0.37 -6.08 -0.32 3.33e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg21854759 chr1:92012499 NA -0.55 -9.23 -0.45 3.13e-18 Breast cancer; LUSC cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg03264133 chr6:25882463 NA -0.34 -5.93 -0.31 7.65e-9 Height; LUSC cis rs10754283 0.967 rs7523518 chr1:90110010 G/A cg21401794 chr1:90099060 LRRC8C 0.64 9.65 0.47 1.33e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9814567 0.896 rs58491661 chr3:134355189 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.86 14.34 0.62 1.08e-36 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg22029157 chr1:209979665 IRF6 0.74 8.74 0.43 1.14e-16 Coronary artery disease; LUSC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.08 -0.36 8.32e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7582720 1.000 rs72936881 chr2:203794262 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7709377 0.574 rs13162293 chr5:115507893 A/G cg23108291 chr5:115420582 COMMD10 0.43 6.13 0.32 2.44e-9 Metabolite levels (X-11787); LUSC cis rs3741151 0.773 rs57673166 chr11:73232557 T/A cg17517138 chr11:73019481 ARHGEF17 0.96 8.06 0.4 1.35e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg21862992 chr11:68658383 NA 0.49 7.88 0.4 4.55e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs6502050 0.777 rs7406162 chr17:80086386 C/T cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.34e-10 Life satisfaction; LUSC cis rs8014204 0.587 rs6574201 chr14:75387256 T/C cg11812906 chr14:75593930 NEK9 -0.4 -5.85 -0.3 1.2e-8 Caffeine consumption; LUSC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg08219700 chr8:58056026 NA 0.54 6.56 0.34 2.05e-10 Developmental language disorder (linguistic errors); LUSC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg19046167 chr17:80928561 B3GNTL1 -0.44 -6.29 -0.33 1.02e-9 Breast cancer; LUSC cis rs4622329 0.615 rs6539019 chr12:102303086 A/G cg23541617 chr12:102225335 GNPTAB 0.27 6.18 0.32 1.9e-9 Systemic lupus erythematosus; LUSC cis rs9611519 0.929 rs9611509 chr22:41565827 A/G cg13813247 chr22:41461852 NA -0.37 -6.77 -0.35 5.91e-11 Neuroticism; LUSC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.14 0.32 2.39e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11785400 0.793 rs750530 chr8:143744931 G/A cg24634471 chr8:143751801 JRK 0.51 7.24 0.37 3.1e-12 Schizophrenia; LUSC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg02807482 chr3:125708958 NA -0.51 -6.3 -0.33 9.37e-10 Blood pressure (smoking interaction); LUSC trans rs11700980 0.551 rs2832037 chr21:30115246 A/C cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg14298792 chr15:30685198 CHRFAM7A 0.48 5.99 0.31 5.47e-9 Huntington's disease progression; LUSC cis rs12681288 0.550 rs59004371 chr8:962393 T/C cg15309053 chr8:964076 NA 0.41 8.04 0.4 1.58e-14 Schizophrenia; LUSC cis rs9354308 0.899 rs2814099 chr6:66555130 A/G cg07460842 chr6:66804631 NA 0.45 5.76 0.3 1.88e-8 Metabolite levels; LUSC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg07741184 chr6:167504864 NA 0.4 7.09 0.36 8.08e-12 Crohn's disease; LUSC cis rs7705502 1.000 rs1484803 chr5:173349840 A/G cg18693985 chr5:173351052 CPEB4 -0.38 -6.03 -0.31 4.32e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1499972 0.941 rs55929115 chr3:117614158 T/A cg07612923 chr3:117604196 NA 0.6 5.66 0.3 3.29e-8 Schizophrenia; LUSC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.46 7.29 0.37 2.2e-12 Alzheimer's disease (late onset); LUSC cis rs77633900 0.614 rs280013 chr15:76978139 C/T cg21673338 chr15:77095150 SCAPER 0.76 7.6 0.38 3.04e-13 Non-glioblastoma glioma;Glioma; LUSC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs8180040 0.932 rs1038394 chr3:47464122 A/G cg27129171 chr3:47204927 SETD2 0.68 11.6 0.54 2.24e-26 Colorectal cancer; LUSC cis rs17739794 0.517 rs6982473 chr8:773986 G/T cg01971667 chr8:817044 NA -0.41 -6.52 -0.34 2.54e-10 Clozapine-induced cytotoxicity; LUSC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.59 -0.34 1.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg00933542 chr6:150070202 PCMT1 0.3 6.01 0.31 4.73e-9 Lung cancer; LUSC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.36 -7.5 -0.38 6e-13 Hemoglobin concentration; LUSC cis rs6964587 1.000 rs10243241 chr7:91705696 A/G cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg16624210 chr5:671434 TPPP 0.49 6.05 0.31 3.83e-9 Lung disease severity in cystic fibrosis; LUSC cis rs6977660 0.943 rs10263564 chr7:19842898 G/C cg05791153 chr7:19748676 TWISTNB 0.57 6.43 0.33 4.54e-10 Thyroid stimulating hormone; LUSC cis rs4629180 0.586 rs1848699 chr2:102137903 C/G cg04415270 chr2:102091202 RFX8 -0.43 -7.37 -0.37 1.38e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs356992 0.915 rs76674 chr2:60749109 C/T cg08426369 chr2:60753602 BCL11A -0.44 -6.2 -0.32 1.69e-9 Educational attainment (years of education); LUSC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg19748678 chr4:122722346 EXOSC9 0.73 10.83 0.51 1.3e-23 Type 2 diabetes; LUSC trans rs9393777 0.720 rs13217285 chr6:26999845 C/T cg06606381 chr12:133084897 FBRSL1 -0.7 -7.2 -0.37 4.11e-12 Intelligence (multi-trait analysis); LUSC cis rs3772130 0.962 rs13433692 chr3:121484714 G/T cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.13 0.48 3.38e-21 Cognitive performance; LUSC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.59 -8.57 -0.42 3.86e-16 Total body bone mineral density; LUSC cis rs6964587 1.000 rs12531366 chr7:91683849 C/G cg17063962 chr7:91808500 NA 0.57 9.03 0.44 1.42e-17 Breast cancer; LUSC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg09796270 chr17:17721594 SREBF1 0.41 7.24 0.37 3.06e-12 Total body bone mineral density; LUSC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs4953076 0.573 rs6738023 chr2:44405931 T/C cg04920474 chr2:44395004 PPM1B 0.68 8.74 0.43 1.14e-16 Height; LUSC cis rs17001868 0.568 rs742140 chr22:40781586 G/A cg07138101 chr22:40742427 ADSL 0.61 7.37 0.37 1.37e-12 Mammographic density (dense area); LUSC cis rs67072384 0.901 rs72964856 chr11:72473299 T/G cg04827223 chr11:72435913 ARAP1 -0.83 -6.47 -0.33 3.44e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9391997 0.568 rs7454545 chr6:434348 A/G cg09757644 chr6:447497 NA -0.28 -5.77 -0.3 1.85e-8 Chronic lymphocytic leukemia; LUSC trans rs7819412 0.595 rs10106914 chr8:10987651 T/G cg15556689 chr8:8085844 FLJ10661 -0.44 -6.27 -0.32 1.1e-9 Triglycerides; LUSC cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.7 0.6 3.39e-34 Chronic sinus infection; LUSC cis rs7267979 0.966 rs910996 chr20:25264196 A/G cg08601574 chr20:25228251 PYGB 0.45 6.95 0.36 1.98e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs344364 0.602 rs2983907 chr16:1913336 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.41 5.99 0.31 5.48e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9921338 1.000 rs9921338 chr16:11416839 T/C cg00044050 chr16:11439710 C16orf75 0.49 6.53 0.34 2.38e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs7914558 1.000 rs7067970 chr10:104913870 C/T cg23093090 chr10:104574429 C10orf26 -0.38 -7.11 -0.36 7e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9910055 0.550 rs850856 chr17:42157739 C/T cg16434002 chr17:42200994 HDAC5 0.47 6.09 0.32 3.15e-9 Total body bone mineral density; LUSC trans rs1728785 1.000 rs4783657 chr16:68586322 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.62 8.12 0.41 9.26e-15 Ulcerative colitis; LUSC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.1e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs6952808 0.792 rs13224989 chr7:1953766 C/G cg04565464 chr8:145669602 NFKBIL2 0.38 6.14 0.32 2.33e-9 Bipolar disorder and schizophrenia; LUSC cis rs56283067 0.887 rs4644056 chr6:44776136 G/T cg20913747 chr6:44695427 NA 0.5 7.57 0.38 3.64e-13 Total body bone mineral density; LUSC cis rs12900413 0.687 rs12908489 chr15:90304269 A/G cg24249390 chr15:90295951 MESP1 -0.37 -5.68 -0.3 2.88e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs7296418 0.961 rs1790106 chr12:123591596 G/T cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.39 -0.42 1.42e-15 Platelet count; LUSC cis rs868036 1.000 rs6494694 chr15:68057142 A/C cg27219399 chr15:67835830 MAP2K5 -0.31 -5.66 -0.3 3.18e-8 Restless legs syndrome; LUSC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg15664640 chr17:80829946 TBCD -0.74 -13.29 -0.59 1.2e-32 Breast cancer; LUSC cis rs2439831 0.702 rs16977724 chr15:44151299 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.91 8.76 0.43 1e-16 Lung cancer in ever smokers; LUSC cis rs9916302 0.706 rs3744349 chr17:37414842 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -9.71 -0.47 8.8e-20 Glomerular filtration rate (creatinine); LUSC trans rs12210905 1.000 rs72843633 chr6:27182949 C/T cg11837749 chr1:55047332 ACOT11 0.59 6.23 0.32 1.37e-9 Hip circumference adjusted for BMI; LUSC trans rs61931739 0.534 rs11052979 chr12:34035774 G/T cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 2.92e-25 Morning vs. evening chronotype; LUSC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg09849774 chr21:43526787 UMODL1;C21orf128 0.41 6.19 0.32 1.79e-9 IgG glycosylation; LUSC cis rs7223966 1.000 rs73337598 chr17:61732576 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.81 0.35 4.6e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg00814883 chr7:100076585 TSC22D4 -0.7 -9.45 -0.46 6.01e-19 Platelet count; LUSC cis rs11758351 0.715 rs76130408 chr6:26208962 A/G cg01420254 chr6:26195488 NA 0.65 6.98 0.36 1.63e-11 Gout;Renal underexcretion gout; LUSC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg23711669 chr6:146136114 FBXO30 0.82 14.9 0.63 7.22e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs11608355 1.000 rs10774695 chr12:109868040 G/A cg19025524 chr12:109796872 NA -0.37 -5.67 -0.3 3.16e-8 Neuroticism; LUSC cis rs7614311 0.636 rs73117066 chr3:63926236 A/G cg22134162 chr3:63841271 THOC7 -0.46 -5.84 -0.3 1.25e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs4466137 0.909 rs4466136 chr5:82985576 T/G cg16102102 chr5:83017553 HAPLN1 -0.91 -14.45 -0.62 4.21e-37 Prostate cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21497417 chr3:185655402 TRA2B -0.41 -5.95 -0.31 6.6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4964805 0.657 rs1866293 chr12:104186655 C/T cg02344784 chr12:104178138 NT5DC3 0.46 8.86 0.44 4.96e-17 Attention deficit hyperactivity disorder; LUSC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg15448220 chr1:150897856 SETDB1 0.39 5.77 0.3 1.84e-8 Melanoma; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg06263672 chr7:65235340 NA 0.41 6.0 0.31 5.2e-9 Calcium levels; LUSC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg24881330 chr22:46731750 TRMU 0.83 7.49 0.38 6.37e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg01017244 chr2:74357527 NA 0.68 13.07 0.58 7.9e-32 Gestational age at birth (maternal effect); LUSC cis rs10791323 0.569 rs10750552 chr11:133740141 A/C cg00579200 chr11:133705235 NA 0.39 5.91 0.31 8.32e-9 Childhood ear infection; LUSC cis rs6138458 0.620 rs2151462 chr20:24911823 T/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.94 -0.36 2.02e-11 Blood protein levels; LUSC cis rs870825 0.616 rs1401359 chr4:185640216 T/C cg04058563 chr4:185651563 MLF1IP 0.86 13.5 0.59 1.99e-33 Blood protein levels; LUSC cis rs3126085 0.935 rs1552993 chr1:152171483 A/G cg26876637 chr1:152193138 HRNR 0.45 6.66 0.34 1.16e-10 Atopic dermatitis; LUSC cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg17173187 chr15:85201210 NMB 0.36 5.8 0.3 1.51e-8 Schizophrenia; LUSC cis rs113835537 0.597 rs11227523 chr11:66305938 C/T cg24851651 chr11:66362959 CCS 0.53 7.97 0.4 2.52e-14 Airway imaging phenotypes; LUSC cis rs3815700 1.000 rs8109990 chr19:33095636 A/G cg02997394 chr19:33096574 ANKRD27 0.8 9.1 0.45 8.16e-18 Eosinophilic esophagitis; LUSC cis rs7605827 0.930 rs1125534 chr2:15618339 G/A cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg08888203 chr3:10149979 C3orf24 0.62 8.05 0.4 1.45e-14 Alzheimer's disease; LUSC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg24920358 chr1:40204285 PPIE 0.61 10.88 0.51 8.73e-24 Blood protein levels; LUSC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg00310523 chr12:86230176 RASSF9 0.49 9.42 0.46 7.56e-19 Major depressive disorder; LUSC cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.01 -0.4 1.98e-14 Chronic sinus infection; LUSC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg06634786 chr22:41940651 POLR3H 0.51 6.13 0.32 2.43e-9 Vitiligo; LUSC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs1018697 1.000 rs7092051 chr10:104559477 C/T cg04362960 chr10:104952993 NT5C2 0.46 6.41 0.33 5.1e-10 Colorectal adenoma (advanced); LUSC cis rs6901250 0.851 rs339361 chr6:117162515 C/T cg12892004 chr6:117198278 RFX6 0.45 8.63 0.43 2.63e-16 C-reactive protein levels; LUSC cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.55 0.42 4.63e-16 Menarche (age at onset); LUSC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg07424592 chr7:64974309 NA 0.67 5.88 0.31 9.86e-9 Diabetic kidney disease; LUSC cis rs1878931 0.517 rs17685105 chr16:3413749 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.84 -14.6 -0.62 1.14e-37 Body mass index (adult); LUSC cis rs3741151 0.773 rs17310374 chr11:73274874 T/C cg17517138 chr11:73019481 ARHGEF17 0.98 8.18 0.41 6.04e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs11039798 0.511 rs717896 chr11:48375335 G/T cg03929089 chr4:120376271 NA -0.58 -6.19 -0.32 1.73e-9 Axial length; LUSC cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg19920283 chr7:105172520 RINT1 0.6 6.38 0.33 5.76e-10 Bipolar disorder (body mass index interaction); LUSC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg06740227 chr12:86229804 RASSF9 0.45 7.16 0.36 5.25e-12 Major depressive disorder; LUSC cis rs6500602 0.702 rs11645519 chr16:4538989 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 6.73 0.35 7.32e-11 Schizophrenia; LUSC cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg07606381 chr6:8435919 SLC35B3 0.72 11.92 0.55 1.52e-27 Motion sickness; LUSC cis rs35146811 0.735 rs1636975 chr7:99812089 A/G cg13334819 chr7:99746414 C7orf59 0.5 6.79 0.35 5.04e-11 Coronary artery disease; LUSC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs2635047 0.875 rs2251948 chr18:44681356 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.91 0.35 2.49e-11 Educational attainment; LUSC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg02915803 chr1:1606292 LOC728661;CDK11B 0.38 5.89 0.31 9.63e-9 Body mass index; LUSC cis rs2486288 0.656 rs2413774 chr15:45549423 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.09e-14 Glomerular filtration rate; LUSC cis rs2795502 0.564 rs72777192 chr10:43436778 G/A cg08461752 chr10:43522343 NA -0.55 -6.45 -0.33 3.85e-10 Blood protein levels; LUSC cis rs427941 0.562 rs6970800 chr7:101780471 T/C cg06246474 chr7:101738831 CUX1 0.38 6.11 0.32 2.76e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs2290416 0.892 rs59742520 chr8:144676234 G/C cg26536354 chr8:144654954 C8orf73 0.68 7.37 0.37 1.32e-12 Attention deficit hyperactivity disorder; LUSC cis rs7107174 0.688 rs2063724 chr11:78133077 T/C cg02023728 chr11:77925099 USP35 0.41 6.26 0.32 1.16e-9 Testicular germ cell tumor; LUSC cis rs11785400 0.963 rs6990126 chr8:143728387 T/C cg10596483 chr8:143751796 JRK 0.61 9.38 0.46 1.02e-18 Schizophrenia; LUSC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.19 0.45 4.34e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs68170813 0.652 rs56949084 chr7:107157387 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs76878669 0.754 rs10896113 chr11:66117111 C/T cg18002602 chr11:66138449 SLC29A2 -0.38 -6.01 -0.31 4.73e-9 Educational attainment (years of education); LUSC trans rs61931739 0.500 rs11053282 chr12:34561151 T/C cg13010199 chr12:38710504 ALG10B 0.67 10.53 0.5 1.43e-22 Morning vs. evening chronotype; LUSC trans rs2587949 0.615 rs2600114 chr3:4225064 G/A cg15139668 chr4:4577005 NA -0.41 -6.11 -0.32 2.76e-9 Periodontitis (DPAL); LUSC cis rs2204008 0.619 rs11178987 chr12:38201258 C/T cg13010199 chr12:38710504 ALG10B -0.52 -7.93 -0.4 3.39e-14 Bladder cancer; LUSC trans rs61931739 0.500 rs11524949 chr12:34435551 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.81 0.65 2.07e-42 Morning vs. evening chronotype; LUSC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.89 0.35 2.8e-11 Intelligence (multi-trait analysis); LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg03395511 chr6:291903 DUSP22 -0.49 -7.45 -0.38 8.13e-13 Menopause (age at onset); LUSC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg03806693 chr22:41940476 POLR3H 0.98 13.91 0.61 5.01e-35 Vitiligo; LUSC cis rs9527 0.590 rs2148198 chr10:104915310 A/G cg04362960 chr10:104952993 NT5C2 -0.61 -9.23 -0.45 3.3e-18 Arsenic metabolism; LUSC cis rs2239815 0.515 rs9625600 chr22:29244395 T/C cg02153584 chr22:29168773 CCDC117 0.53 6.04 0.31 4.15e-9 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC cis rs208520 1.000 rs208527 chr6:66957209 A/C cg07460842 chr6:66804631 NA -0.96 -12.45 -0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs4268898 0.735 rs34125395 chr2:24558242 C/T cg06627628 chr2:24431161 ITSN2 0.57 8.05 0.4 1.45e-14 Asthma; LUSC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg25456477 chr12:86230367 RASSF9 0.39 6.88 0.35 2.96e-11 Major depressive disorder; LUSC cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.93 0.31 7.75e-9 Rheumatoid arthritis; LUSC cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg25208724 chr1:156163844 SLC25A44 1.1 26.44 0.82 6.48e-84 Testicular germ cell tumor; LUSC cis rs68170813 0.559 rs1989814 chr7:107045076 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.28 -0.45 2.28e-18 Coronary artery disease; LUSC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 5.84 0.3 1.24e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.47 0.46 5.4e-19 Prudent dietary pattern; LUSC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg25319279 chr11:5960081 NA 0.42 6.21 0.32 1.59e-9 DNA methylation (variation); LUSC trans rs1945213 0.694 rs67394518 chr11:55855303 G/A cg03929089 chr4:120376271 NA 0.71 7.27 0.37 2.61e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs6500602 0.855 rs1139652 chr16:4476089 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 6.94 0.36 2.02e-11 Schizophrenia; LUSC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg11645453 chr3:52864694 ITIH4 0.32 7.62 0.38 2.61e-13 Bipolar disorder; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.92 -0.35 2.27e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2479724 0.846 rs2488338 chr6:41808351 A/G cg17623882 chr6:41773611 USP49 -0.57 -9.58 -0.46 2.36e-19 Menarche (age at onset); LUSC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.69 11.65 0.54 1.51e-26 Menarche (age at onset); LUSC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg04539111 chr16:67997858 SLC12A4 -0.42 -5.86 -0.31 1.12e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs977987 0.872 rs4888422 chr16:75470576 A/G cg04384234 chr16:75411784 CFDP1 -0.42 -7.12 -0.36 6.5e-12 Dupuytren's disease; LUSC cis rs10186029 0.667 rs6734174 chr2:213981428 A/C cg08319019 chr2:214017104 IKZF2 -0.54 -7.59 -0.38 3.3e-13 Systemic sclerosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05372549 chr1:11119861 SRM 0.48 6.68 0.34 1e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg18350739 chr11:68623251 NA -0.38 -6.87 -0.35 3.16e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg09184832 chr6:79620586 NA 0.45 7.15 0.36 5.35e-12 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg01657329 chr11:68192670 LRP5 -0.43 -6.39 -0.33 5.53e-10 Total body bone mineral density; LUSC cis rs1577917 0.874 rs1838954 chr6:86565478 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.54 -0.34 2.32e-10 Response to antipsychotic treatment; LUSC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg23422044 chr7:1970798 MAD1L1 -0.55 -5.7 -0.3 2.68e-8 Neuroticism; LUSC cis rs858239 0.539 rs10225608 chr7:23188908 A/G cg23682824 chr7:23144976 KLHL7 0.4 5.71 0.3 2.52e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg09455208 chr3:40491958 NA 0.58 9.77 0.47 5.57e-20 Renal cell carcinoma; LUSC cis rs1572438 0.811 rs9379179 chr6:879853 A/C cg21062780 chr6:887772 NA 0.35 5.81 0.3 1.43e-8 Aging; LUSC cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg24130564 chr14:104152367 KLC1 -0.47 -6.82 -0.35 4.31e-11 Intelligence (multi-trait analysis); LUSC cis rs1348850 0.567 rs12994392 chr2:178536640 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.43 5.85 0.3 1.19e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3126085 0.799 rs11589532 chr1:152176539 G/A cg03465714 chr1:152285911 FLG 0.41 5.66 0.3 3.22e-8 Atopic dermatitis; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg21782813 chr7:2030301 MAD1L1 0.52 9.21 0.45 3.81e-18 Bipolar disorder and schizophrenia; LUSC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.59 0.38 3.23e-13 Mean platelet volume; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg04234412 chr22:24373322 LOC391322 -0.82 -13.22 -0.59 2.27e-32 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11785400 0.793 rs13248524 chr8:143739343 T/C cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs4631830 0.863 rs2611507 chr10:51518673 T/C cg10326726 chr10:51549505 MSMB -0.34 -5.87 -0.31 1.06e-8 Prostate-specific antigen levels; LUSC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg00509249 chr6:109615579 CCDC162 -0.34 -6.12 -0.32 2.6e-9 Reticulocyte fraction of red cells; LUSC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.04 -0.36 1.13e-11 Intelligence (multi-trait analysis); LUSC trans rs80346118 0.850 rs17366644 chr20:47466627 A/G cg16950247 chr11:62911616 SLC22A24 0.48 5.95 0.31 6.79e-9 Diastolic blood pressure; LUSC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg21856205 chr7:94953877 PON1 -0.36 -5.8 -0.3 1.56e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg09626299 chr10:82213104 TSPAN14 -0.21 -6.29 -0.33 9.7e-10 Post bronchodilator FEV1; LUSC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -7.04 -0.36 1.08e-11 Alzheimer's disease (late onset); LUSC cis rs7582720 0.945 rs116773016 chr2:203811902 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs12530845 0.673 rs73721607 chr7:135335822 C/T cg23117316 chr7:135346802 PL-5283 -0.62 -9.56 -0.46 2.64e-19 Red blood cell traits; LUSC cis rs6964587 0.967 rs10231350 chr7:91808499 G/T cg01689657 chr7:91764605 CYP51A1 0.31 5.66 0.3 3.32e-8 Breast cancer; LUSC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg06484146 chr7:12443880 VWDE -0.73 -7.35 -0.37 1.58e-12 Coronary artery disease; LUSC trans rs10511400 0.618 rs6438559 chr3:119867015 A/G cg02809009 chr19:50354510 PTOV1 -0.67 -6.12 -0.32 2.67e-9 Economic and political preferences (feminism/equality); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16058774 chr6:107349438 C6orf203 -0.41 -6.12 -0.32 2.62e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15229027 chr14:64805542 ESR2 0.44 6.12 0.32 2.56e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg16797656 chr11:68205561 LRP5 0.36 6.01 0.31 4.74e-9 Total body bone mineral density; LUSC cis rs9300255 0.596 rs10734901 chr12:123743447 G/A cg05973401 chr12:123451056 ABCB9 0.52 7.01 0.36 1.32e-11 Neutrophil percentage of white cells; LUSC cis rs4253772 0.678 rs9627281 chr22:46644168 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.48 6.47 0.33 3.59e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg24846343 chr22:24311635 DDTL 0.66 14.6 0.62 1.14e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs16910800 0.953 rs73481423 chr11:23205302 T/C cg20040320 chr11:23191996 NA -0.44 -6.45 -0.33 3.85e-10 Cancer; LUSC trans rs7726839 0.507 rs111707179 chr5:593308 T/A cg11887960 chr12:57824829 NA 0.55 6.81 0.35 4.57e-11 Obesity-related traits; LUSC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg18357526 chr6:26021779 HIST1H4A 0.42 6.28 0.32 1.08e-9 Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg06022373 chr22:39101656 GTPBP1 0.84 13.96 0.61 3.35e-35 Menopause (age at onset); LUSC cis rs36405 0.500 rs4622450 chr14:72355812 T/C cg23396177 chr14:72358413 NA -0.38 -7.04 -0.36 1.11e-11 Yang-deficiency constitution; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg11351687 chr6:170863423 PSMB1;TBP 0.53 6.42 0.33 4.64e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs870142 0.883 rs73203669 chr4:4641569 C/G cg04017672 chr1:182359056 GLUL 0.4 5.99 0.31 5.39e-9 Congenital heart disease; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.93 -0.4 3.38e-14 Lymphocyte counts; LUSC trans rs208520 0.690 rs851464 chr6:66839802 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -16.94 -0.68 6.8e-47 Exhaled nitric oxide output; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg19747945 chr6:42946146 PEX6 -0.34 -5.67 -0.3 3.11e-8 Plasma homocysteine levels (post-methionine load test); LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg05896524 chr21:47604654 C21orf56 0.58 8.96 0.44 2.37e-17 Testicular germ cell tumor; LUSC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg13798780 chr7:105162888 PUS7 0.57 6.06 0.31 3.62e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2777491 0.957 rs919961 chr15:41651721 A/G cg18705301 chr15:41695430 NDUFAF1 -0.74 -14.14 -0.61 6.46e-36 Ulcerative colitis; LUSC cis rs7560272 0.723 rs780395 chr2:73700853 G/A cg20560298 chr2:73613845 ALMS1 0.46 7.19 0.37 4.24e-12 Schizophrenia; LUSC cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.38 -6.26 -0.32 1.2e-9 Longevity;Endometriosis; LUSC cis rs1143633 0.530 rs4538207 chr2:113701863 G/T cg06156847 chr2:113672199 IL1F7 -0.28 -5.83 -0.3 1.32e-8 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9807841 0.568 rs1560708 chr19:10749236 T/C cg17710535 chr19:10819994 QTRT1 0.4 6.59 0.34 1.69e-10 Inflammatory skin disease; LUSC cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg05472934 chr7:22766657 IL6 -0.53 -8.1 -0.41 1.04e-14 Lung cancer; LUSC cis rs10484885 0.877 rs17735389 chr6:90323139 G/T cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.59 -0.38 3.16e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9814567 0.896 rs1357764 chr3:134344928 T/G cg15484384 chr3:134203672 ANAPC13;CEP63 0.31 5.87 0.31 1.06e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.82 0.35 4.17e-11 Platelet count; LUSC trans rs72674100 0.737 rs72874649 chr4:97965312 T/C cg16405019 chr1:18959625 PAX7 -0.64 -6.78 -0.35 5.33e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg12564285 chr5:131593104 PDLIM4 0.37 6.87 0.35 3.17e-11 Blood metabolite levels; LUSC cis rs12980942 0.515 rs12980839 chr19:41820213 G/A cg25627403 chr19:41769009 HNRNPUL1 0.45 5.66 0.3 3.23e-8 Coronary artery disease; LUSC trans rs2975734 0.709 rs6988826 chr8:10109625 T/C cg15556689 chr8:8085844 FLJ10661 -0.51 -6.51 -0.34 2.71e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs73195822 0.614 rs17190144 chr12:111214767 A/G cg12870014 chr12:110450643 ANKRD13A 0.69 7.06 0.36 9.82e-12 Itch intensity from mosquito bite; LUSC cis rs17407555 0.779 rs4459989 chr4:10112602 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.01 -0.31 4.94e-9 Schizophrenia (age at onset); LUSC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.76 0.57 1.24e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02559264 chr11:73490474 NA 0.43 6.47 0.33 3.39e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2274273 0.804 rs28428911 chr14:55843596 G/T cg04306507 chr14:55594613 LGALS3 0.53 11.62 0.54 1.94e-26 Protein biomarker; LUSC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg23887609 chr12:130822674 PIWIL1 0.49 7.27 0.37 2.65e-12 Menopause (age at onset); LUSC cis rs3764021 0.870 rs7976584 chr12:9878655 C/T cg20894963 chr12:9885564 CLECL1 0.34 6.9 0.35 2.57e-11 Type 1 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18632100 chr19:59028615 ZBTB45 0.49 6.82 0.35 4.27e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg00763151 chr12:98987211 SLC25A3 0.35 6.06 0.31 3.73e-9 Metabolite levels (Pyroglutamine); LUSC cis rs1670533 1.000 rs2045068 chr4:1052212 G/A cg27284194 chr4:1044797 NA 0.58 8.61 0.43 2.92e-16 Recombination rate (females); LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg19318889 chr4:1322082 MAEA -0.78 -13.96 -0.61 3.39e-35 Longevity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14107975 chr11:96076498 MAML2 -0.5 -6.71 -0.34 8.35e-11 Bipolar disorder and schizophrenia; LUSC trans rs1499614 1.000 rs1267817 chr7:66110040 G/T cg10756647 chr7:56101905 PSPH 0.88 8.96 0.44 2.32e-17 Gout; LUSC trans rs3942852 0.806 rs10769317 chr11:48150712 T/C cg15704280 chr7:45808275 SEPT13 -0.6 -7.31 -0.37 1.99e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs7715806 0.500 rs17563589 chr5:74980019 A/G cg19683494 chr5:74908142 NA 0.58 7.92 0.4 3.64e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11166629 1.000 rs1036820 chr8:135646571 C/T cg27224718 chr8:135614730 ZFAT -0.62 -10.36 -0.49 5.35e-22 Smoking quantity; LUSC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg03709012 chr19:19516395 GATAD2A 0.87 14.72 0.63 3.76e-38 Tonsillectomy; LUSC cis rs6005807 0.719 rs12169071 chr22:29033210 C/G cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs4474465 0.920 rs908002 chr11:78144753 T/A cg27205649 chr11:78285834 NARS2 -0.52 -5.96 -0.31 6.28e-9 Alzheimer's disease (survival time); LUSC trans rs7944735 0.507 rs7114598 chr11:48101766 C/T cg03929089 chr4:120376271 NA 0.54 6.65 0.34 1.19e-10 Intraocular pressure; LUSC cis rs6500602 0.561 rs62039231 chr16:4519548 A/G cg08645402 chr16:4508243 NA 0.53 9.08 0.45 9.4e-18 Schizophrenia; LUSC cis rs806215 1.000 rs806196 chr7:127248414 A/G cg25922125 chr7:127225783 GCC1 0.57 7.17 0.37 4.96e-12 Type 2 diabetes; LUSC cis rs7582180 0.629 rs12621892 chr2:100947124 G/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs7312933 0.533 rs11181499 chr12:42818761 A/G cg01256987 chr12:42539512 GXYLT1 -0.39 -7.15 -0.36 5.43e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg23158103 chr7:148848205 ZNF398 -0.48 -7.98 -0.4 2.33e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs3008870 1.000 rs2815357 chr1:67491854 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.96 15.46 0.65 4.83e-41 Lymphocyte percentage of white cells; LUSC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg08975724 chr8:8085496 FLJ10661 -0.54 -8.21 -0.41 4.89e-15 Mood instability; LUSC cis rs7640424 0.754 rs182736 chr3:107838891 C/A cg09227934 chr3:107805635 CD47 0.43 6.68 0.34 1.01e-10 Body mass index; LUSC cis rs12617721 0.645 rs114544871 chr2:99045485 T/G cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4356932 0.935 rs7677924 chr4:76977023 C/A cg00809888 chr4:76862425 NAAA 0.34 5.66 0.3 3.25e-8 Blood protein levels; LUSC trans rs1486139 1.000 rs1903673 chr7:46282628 A/G cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs10782582 0.609 rs1630302 chr1:76412090 A/T cg03433033 chr1:76189801 ACADM -0.41 -6.13 -0.32 2.47e-9 Daytime sleep phenotypes; LUSC cis rs11748023 0.605 rs152409 chr5:139521808 T/C cg26211634 chr5:139558579 C5orf32 0.32 5.69 0.3 2.81e-8 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs1145074 chr15:45703824 T/A cg14582100 chr15:45693742 SPATA5L1 0.57 10.0 0.48 9.11e-21 Homoarginine levels; LUSC cis rs11190604 1.000 rs11190557 chr10:102209369 G/A cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg11764359 chr7:65958608 NA -0.42 -6.01 -0.31 4.94e-9 Calcium levels; LUSC cis rs1048238 0.506 rs12023422 chr1:16187625 G/A cg22431228 chr1:16359049 CLCNKA -0.42 -8.46 -0.42 8.3e-16 Systolic blood pressure; LUSC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg24531977 chr5:56204891 C5orf35 -0.71 -10.4 -0.49 3.84e-22 Coronary artery disease; LUSC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg17948913 chr5:572064 NA 0.33 5.7 0.3 2.63e-8 Ulcerative colitis; LUSC cis rs367943 0.712 rs10035686 chr5:112683357 C/T cg12552261 chr5:112820674 MCC 0.39 6.37 0.33 6.4e-10 Type 2 diabetes; LUSC cis rs11030122 0.673 rs4910597 chr11:4094923 G/A cg08557956 chr11:4115526 RRM1 -0.46 -5.83 -0.3 1.31e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs367943 0.712 rs9326886 chr5:112728458 A/C cg12552261 chr5:112820674 MCC 0.36 5.84 0.3 1.21e-8 Type 2 diabetes; LUSC cis rs11123610 0.520 rs13409381 chr2:3722579 A/G cg25251562 chr2:3704773 ALLC -0.48 -7.28 -0.37 2.45e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.4 -0.33 5.23e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs8018808 0.870 rs11159264 chr14:77937017 T/C cg20045696 chr14:77926864 AHSA1 0.34 5.74 0.3 2.11e-8 Myeloid white cell count; LUSC cis rs459571 0.959 rs2810491 chr9:136923331 C/T cg13789015 chr9:136890014 NCRNA00094 -0.68 -12.4 -0.56 2.55e-29 Platelet distribution width; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22050555 chr5:171615449 STK10 -0.52 -6.63 -0.34 1.33e-10 Bipolar disorder and schizophrenia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12077875 chr20:47835964 DDX27 0.4 6.33 0.33 7.69e-10 Asthma; LUSC cis rs734999 0.545 rs12749591 chr1:2563250 G/T cg18854424 chr1:2615690 NA -0.52 -10.73 -0.51 2.77e-23 Ulcerative colitis; LUSC cis rs9329221 0.736 rs11250002 chr8:10257041 T/G cg21775007 chr8:11205619 TDH 0.44 5.87 0.31 1.05e-8 Neuroticism; LUSC cis rs3126085 0.935 rs10888473 chr1:152220235 G/A cg26876637 chr1:152193138 HRNR 0.46 6.28 0.32 1.05e-9 Atopic dermatitis; LUSC cis rs68170813 0.559 rs12537733 chr7:106965447 A/T cg02696742 chr7:106810147 HBP1 -0.65 -9.77 -0.47 5.25e-20 Coronary artery disease; LUSC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg02175503 chr12:58329896 NA 0.59 8.91 0.44 3.36e-17 Intelligence (multi-trait analysis); LUSC trans rs11723530 0.538 rs4692763 chr4:170814362 T/G cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.28 -0.32 1.03e-9 Myopia (pathological); LUSC cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.15 -0.36 5.66e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs739401 0.527 rs418832 chr11:3072236 C/T cg25174290 chr11:3078921 CARS 0.58 9.15 0.45 5.85e-18 Longevity; LUSC cis rs73206853 0.698 rs73191806 chr12:110899913 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg02569458 chr12:86230093 RASSF9 0.58 9.82 0.47 3.54e-20 Major depressive disorder; LUSC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg17294928 chr15:75287854 SCAMP5 0.43 6.26 0.32 1.18e-9 Breast cancer; LUSC cis rs1215050 0.791 rs1530904 chr4:98805436 A/G cg05340658 chr4:99064831 C4orf37 0.44 7.0 0.36 1.41e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg19824325 chr16:58548873 SETD6 0.95 9.65 0.47 1.36e-19 Schizophrenia; LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.15 0.32 2.16e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs62238980 0.614 rs1475997 chr22:32465025 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg08999081 chr20:33150536 PIGU -0.37 -6.83 -0.35 3.93e-11 Height; LUSC cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg21573476 chr21:45109991 RRP1B 0.37 5.91 0.31 8.65e-9 Mean corpuscular volume; LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.89 0.48 2.14e-20 Bipolar disorder; LUSC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg21545522 chr1:205238299 TMCC2 0.49 9.19 0.45 4.28e-18 Mean corpuscular volume;Mean platelet volume; LUSC trans rs8072100 0.811 rs9889709 chr17:45445229 C/T cg03886242 chr7:26192032 NFE2L3 -0.4 -6.47 -0.33 3.54e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11229555 0.609 rs12286421 chr11:58174898 A/G cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs11711311 1.000 rs3773682 chr3:113520576 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.75 -0.3 1.97e-8 IgG glycosylation; LUSC cis rs950169 0.519 rs7237 chr15:85186577 C/T cg12863693 chr15:85201151 NMB 0.37 7.69 0.39 1.63e-13 Schizophrenia; LUSC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg03609598 chr5:56110824 MAP3K1 -0.39 -5.86 -0.31 1.08e-8 Initial pursuit acceleration; LUSC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg06618935 chr21:46677482 NA -0.41 -8.22 -0.41 4.49e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg22875332 chr1:76189707 ACADM 0.79 11.11 0.52 1.32e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2295359 0.892 rs72676069 chr1:67658954 T/C cg12940439 chr1:67600707 NA 0.39 6.2 0.32 1.7e-9 Psoriasis; LUSC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg21028142 chr17:79581711 NPLOC4 -0.32 -7.79 -0.39 8.41e-14 Eye color traits; LUSC cis rs7215564 0.822 rs2340771 chr17:78752947 A/C cg23238734 chr17:78661607 RPTOR -0.44 -5.65 -0.3 3.4e-8 Myopia (pathological); LUSC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.76 -0.35 6.3e-11 Total body bone mineral density; LUSC cis rs10791323 0.569 rs2156680 chr11:133742292 T/G cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC trans rs2228479 0.850 rs11644213 chr16:89837367 C/T cg24644049 chr4:85504048 CDS1 -0.86 -7.74 -0.39 1.22e-13 Skin colour saturation; LUSC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg00409905 chr10:38381863 ZNF37A -0.33 -5.75 -0.3 1.99e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7927592 0.513 rs607887 chr11:68196961 C/T cg16797656 chr11:68205561 LRP5 0.46 8.29 0.41 2.75e-15 Total body bone mineral density; LUSC cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg02527881 chr3:46936655 PTH1R -0.39 -6.76 -0.35 6.22e-11 Colorectal cancer; LUSC cis rs77633900 0.614 rs2439993 chr15:76861532 G/A cg21673338 chr15:77095150 SCAPER -0.71 -7.14 -0.36 6.05e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs9287719 0.967 rs6735074 chr2:10734766 G/T cg01299579 chr2:10830716 NOL10 0.36 5.73 0.3 2.21e-8 Prostate cancer; LUSC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg06028605 chr16:24865363 SLC5A11 0.68 10.63 0.5 6.19e-23 Intelligence (multi-trait analysis); LUSC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg12365402 chr11:9010492 NRIP3 -0.52 -9.88 -0.48 2.31e-20 Hemoglobin concentration; LUSC cis rs950881 0.601 rs3771164 chr2:102991786 A/T cg20060108 chr2:102954350 IL1RL1 0.47 6.25 0.32 1.22e-9 Allergy; LUSC cis rs17401966 1.000 rs4846210 chr1:10322153 A/G cg19773385 chr1:10388646 KIF1B -0.53 -8.3 -0.41 2.57e-15 Hepatocellular carcinoma; LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.21 -0.32 1.61e-9 Developmental language disorder (linguistic errors); LUSC trans rs12579753 0.879 rs11115009 chr12:82165409 G/T cg07923666 chr12:49932857 KCNH3 0.48 6.06 0.31 3.64e-9 Resting heart rate; LUSC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg20203395 chr5:56204925 C5orf35 -0.73 -9.87 -0.48 2.58e-20 Initial pursuit acceleration; LUSC cis rs796364 0.806 rs74706215 chr2:200941367 T/C cg23649088 chr2:200775458 C2orf69 -0.57 -7.0 -0.36 1.41e-11 Schizophrenia; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.4 6.35 0.33 7.23e-10 Metabolite levels (Pyroglutamine); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg17032565 chr2:110260096 SH3RF3 -0.37 -6.44 -0.33 4.28e-10 Schizophrenia; LUSC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg02463440 chr8:22132932 PIWIL2 -0.43 -7.95 -0.4 2.86e-14 Hypertriglyceridemia; LUSC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg21782813 chr7:2030301 MAD1L1 -0.47 -8.04 -0.4 1.61e-14 Bipolar disorder and schizophrenia; LUSC cis rs734999 0.588 rs3748818 chr1:2525660 G/A cg18854424 chr1:2615690 NA 0.49 9.83 0.47 3.49e-20 Ulcerative colitis; LUSC cis rs6736093 0.966 rs3811633 chr2:112754880 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -6.06 -0.31 3.65e-9 Coronary artery disease; LUSC cis rs13385 0.769 rs7715649 chr5:139605517 G/A cg26211634 chr5:139558579 C5orf32 0.45 6.75 0.35 6.51e-11 Atrial fibrillation; LUSC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg22166914 chr1:53195759 ZYG11B 0.64 10.62 0.5 6.66e-23 Monocyte count; LUSC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.14 0.32 2.31e-9 Schizophrenia; LUSC cis rs11719291 0.915 rs1048940 chr3:48725707 C/T cg01304814 chr3:48885189 PRKAR2A 0.86 5.83 0.3 1.31e-8 Cognitive function; LUSC cis rs877282 0.898 rs11253338 chr10:759559 C/T cg17470449 chr10:769945 NA 0.48 6.78 0.35 5.49e-11 Uric acid levels; LUSC cis rs6599077 0.616 rs11716640 chr3:40175332 T/A cg13683864 chr3:40499215 RPL14 -0.55 -6.9 -0.35 2.55e-11 Sleep-related phenotypes; LUSC cis rs72781680 0.898 rs72782137 chr2:24047805 C/T cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs709400 0.663 rs62007687 chr14:103903763 G/T cg12935359 chr14:103987150 CKB -0.56 -8.49 -0.42 6.64e-16 Body mass index; LUSC cis rs4722404 0.643 rs4722443 chr7:3156031 T/C cg19214707 chr7:3157722 NA 0.35 6.47 0.33 3.58e-10 Atopic dermatitis; LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.05 -0.31 3.93e-9 Platelet count; LUSC cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg23158103 chr7:148848205 ZNF398 -0.51 -8.49 -0.42 6.87e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7100689 0.622 rs2342816 chr10:82086546 G/A cg01528321 chr10:82214614 TSPAN14 0.82 12.33 0.56 4.69e-29 Post bronchodilator FEV1; LUSC cis rs7119 0.604 rs2682927 chr15:77859168 C/T cg27398640 chr15:77910606 LINGO1 0.36 7.72 0.39 1.35e-13 Type 2 diabetes; LUSC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg27170947 chr2:26402098 FAM59B -0.62 -9.21 -0.45 3.74e-18 Gut microbiome composition (summer); LUSC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg09034736 chr1:150693464 HORMAD1 -0.41 -5.88 -0.31 1.01e-8 Tonsillectomy; LUSC cis rs7100689 0.784 rs2153455 chr10:82139732 T/C cg00277334 chr10:82204260 NA -0.48 -6.5 -0.34 2.94e-10 Post bronchodilator FEV1; LUSC cis rs13082711 0.911 rs7640929 chr3:27513944 C/A cg02860705 chr3:27208620 NA 0.48 8.0 0.4 2e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs2011503 0.739 rs8108659 chr19:19680738 T/A cg11244672 chr19:19639970 YJEFN3 0.46 6.05 0.31 3.94e-9 Bipolar disorder; LUSC cis rs1448094 0.617 rs7297449 chr12:86468442 A/C cg00310523 chr12:86230176 RASSF9 -0.34 -6.21 -0.32 1.59e-9 Major depressive disorder; LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg08736216 chr1:53307985 ZYG11A -0.28 -5.72 -0.3 2.39e-8 Monocyte count; LUSC cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg17366294 chr4:99064904 C4orf37 0.61 10.78 0.51 1.87e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs8002861 0.935 rs7319725 chr13:44445421 T/C cg12856521 chr11:46389249 DGKZ 0.42 6.67 0.34 1.04e-10 Leprosy; LUSC cis rs4073416 0.542 rs7145500 chr14:65884212 G/A cg03016385 chr14:66212404 NA -0.38 -5.83 -0.3 1.29e-8 N-glycan levels; LUSC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg18876405 chr7:65276391 NA -0.58 -9.31 -0.45 1.8e-18 Aortic root size; LUSC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.29 -0.41 2.78e-15 Intelligence (multi-trait analysis); LUSC cis rs12579753 0.871 rs35801863 chr12:82238818 A/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs6546550 0.901 rs6546553 chr2:70111711 C/A cg02498382 chr2:70120550 SNRNP27 -0.31 -7.49 -0.38 6.21e-13 Prevalent atrial fibrillation; LUSC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.41 -0.42 1.23e-15 Height; LUSC cis rs11756438 0.572 rs2638529 chr6:119006459 T/C cg18833306 chr6:118973337 C6orf204 0.37 5.77 0.3 1.8e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7100689 0.646 rs1340375 chr10:82129039 C/T cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 11.6 0.54 2.28e-26 Alzheimer's disease; LUSC cis rs8060686 0.641 rs9932251 chr16:68131732 G/A cg27539214 chr16:67997921 SLC12A4 -0.55 -7.56 -0.38 3.86e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg24692254 chr21:30365293 RNF160 -0.79 -14.4 -0.62 6.32e-37 Dental caries; LUSC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.44 0.33 4.12e-10 Menopause (age at onset); LUSC cis rs2204008 0.623 rs1315348 chr12:38163044 G/A cg13010199 chr12:38710504 ALG10B -0.52 -7.93 -0.4 3.43e-14 Bladder cancer; LUSC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg04362960 chr10:104952993 NT5C2 0.58 9.38 0.46 1.02e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg00431813 chr7:1051703 C7orf50 -0.39 -6.41 -0.33 4.98e-10 Longevity;Endometriosis; LUSC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg20135002 chr11:47629003 NA 0.48 7.51 0.38 5.54e-13 Subjective well-being; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg27288777 chr17:30264551 SUZ12 -0.41 -5.95 -0.31 6.61e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.83 -0.81 7.74e-78 Height; LUSC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.32 0.33 8.21e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01737828 chr15:75230659 COX5A 0.43 5.98 0.31 5.59e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4631830 0.863 rs2843549 chr10:51521247 C/A cg16070123 chr10:51489643 NA -0.51 -8.08 -0.4 1.23e-14 Prostate-specific antigen levels; LUSC cis rs983392 0.679 rs10736700 chr11:60031399 T/C cg24026212 chr11:59952134 MS4A6A 0.36 6.2 0.32 1.71e-9 Alzheimer's disease (late onset); LUSC cis rs3741151 0.773 rs73542979 chr11:73127526 G/C cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10740039 0.961 rs2083696 chr10:62416188 G/C cg18175470 chr10:62150864 ANK3 -0.43 -6.8 -0.35 4.8e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12458462 0.851 rs60298379 chr18:77488422 C/T cg11879182 chr18:77439856 CTDP1 0.7 10.45 0.5 2.56e-22 Monocyte count; LUSC cis rs7250872 0.647 rs12976128 chr19:1817113 A/C cg18850929 chr19:1828978 REXO1 0.41 5.97 0.31 6.2e-9 Bipolar disorder; LUSC cis rs4900538 0.855 rs9788420 chr14:102839338 A/G cg18135206 chr14:102964638 TECPR2 -0.98 -19.19 -0.72 7.44e-56 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7659604 0.540 rs10020581 chr4:122676559 A/C cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs3772130 0.545 rs7340674 chr3:121574215 T/C cg11130432 chr3:121712080 ILDR1 0.36 5.77 0.3 1.84e-8 Cognitive performance; LUSC cis rs708547 0.836 rs1625691 chr4:57845740 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.66 9.25 0.45 2.67e-18 Response to bleomycin (chromatid breaks); LUSC cis rs2797685 1.000 rs707467 chr1:7861684 A/C cg04725166 chr1:7887271 PER3 -0.45 -6.19 -0.32 1.75e-9 Crohn's disease; LUSC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg22431228 chr1:16359049 CLCNKA -0.47 -9.1 -0.45 8.22e-18 Dilated cardiomyopathy; LUSC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg04315214 chr1:2043799 PRKCZ 0.47 9.63 0.47 1.59e-19 Height; LUSC cis rs7584330 0.695 rs6709497 chr2:238368925 C/T cg14458575 chr2:238380390 NA 0.66 11.6 0.54 2.28e-26 Prostate cancer; LUSC cis rs9303542 0.559 rs12951076 chr17:46625109 T/C cg09704116 chr17:46666958 LOC404266 -0.37 -5.97 -0.31 6.11e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC trans rs3960554 0.932 rs4728614 chr7:75841589 A/G cg19862616 chr7:65841803 NCRNA00174 -0.85 -9.6 -0.47 2e-19 Eotaxin levels; LUSC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg00290607 chr11:67383545 NA 0.35 6.66 0.34 1.14e-10 Mean corpuscular volume; LUSC cis rs6938 0.534 rs59945415 chr15:75228427 C/A cg14664628 chr15:75095509 CSK -0.54 -8.05 -0.4 1.42e-14 Breast cancer; LUSC cis rs909341 1.000 rs909341 chr20:62328742 C/T cg09650180 chr20:62225654 GMEB2 -0.44 -5.78 -0.3 1.73e-8 Atopic dermatitis; LUSC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs4704187 0.663 rs7735057 chr5:74403857 T/A cg03227963 chr5:74354835 NA 0.33 7.06 0.36 9.4e-12 Response to amphetamines; LUSC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs244293 0.760 rs1990673 chr17:53050025 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.38 -5.71 -0.3 2.54e-8 Menarche (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13682044 chr17:41623249 ETV4 0.72 6.06 0.31 3.62e-9 Cognitive performance; LUSC cis rs1568889 1.000 rs12802157 chr11:28060285 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC cis rs1018836 0.923 rs10956748 chr8:91621537 T/A cg16814680 chr8:91681699 NA -0.77 -12.95 -0.58 2.23e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs17270561 0.636 rs9379782 chr6:25715023 G/A cg16482183 chr6:26056742 HIST1H1C 0.68 9.3 0.45 1.91e-18 Iron status biomarkers; LUSC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.36 0.46 1.24e-18 Monocyte percentage of white cells; LUSC cis rs116988415 0.584 rs747858 chr14:65239772 G/A cg25083366 chr14:65239357 SPTB 0.7 6.65 0.34 1.19e-10 Daytime sleep phenotypes; LUSC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg12963246 chr6:28129442 ZNF389 0.52 7.17 0.37 4.94e-12 Depression; LUSC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7408868 1.000 rs10422818 chr19:15285272 A/G cg14696996 chr19:15285081 NOTCH3 0.84 7.51 0.38 5.49e-13 Pulse pressure; LUSC cis rs6754311 0.731 rs12988076 chr2:136569848 C/A cg07169764 chr2:136633963 MCM6 -0.58 -7.55 -0.38 4.09e-13 Mosquito bite size; LUSC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg07414643 chr4:187882934 NA 0.55 10.53 0.5 1.41e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs12824058 0.737 rs2398510 chr12:130816637 G/A cg23887609 chr12:130822674 PIWIL1 0.44 6.34 0.33 7.46e-10 Menopause (age at onset); LUSC trans rs7824557 0.836 rs2736378 chr8:11119760 G/A cg06636001 chr8:8085503 FLJ10661 -0.58 -9.1 -0.45 8.64e-18 Retinal vascular caliber; LUSC cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg27535305 chr1:53392650 SCP2 0.39 7.23 0.37 3.27e-12 Monocyte count; LUSC cis rs12118280 0.531 rs2336019 chr1:108757756 T/C cg11967332 chr1:108735228 SLC25A24 0.43 6.13 0.32 2.55e-9 Myeloid white cell count; LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg17541715 chr7:1216824 NA -0.36 -5.8 -0.3 1.54e-8 Longevity;Endometriosis; LUSC cis rs6722750 0.651 rs2901646 chr2:64414892 A/G cg22352474 chr2:64371530 PELI1 0.52 7.94 0.4 3.18e-14 Neuroticism; LUSC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg26597838 chr10:835615 NA 0.85 11.84 0.54 3e-27 Eosinophil percentage of granulocytes; LUSC cis rs35306767 0.714 rs12767171 chr10:1084491 A/G cg20503657 chr10:835505 NA 0.52 7.0 0.36 1.45e-11 Eosinophil percentage of granulocytes; LUSC cis rs738322 0.836 rs4821741 chr22:38514745 A/G cg25457927 chr22:38595422 NA -0.35 -6.82 -0.35 4.17e-11 Cutaneous nevi; LUSC cis rs1358748 0.522 rs2144656 chr1:67579386 A/G cg02640540 chr1:67518911 SLC35D1 0.63 6.1 0.32 2.9e-9 Tuberculosis; LUSC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg03732007 chr1:2071316 PRKCZ -0.54 -10.0 -0.48 9.19e-21 Height; LUSC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2180341 0.574 rs13192350 chr6:127677762 G/T cg27446573 chr6:127587934 RNF146 0.62 9.85 0.47 2.86e-20 Breast cancer; LUSC cis rs62400317 0.826 rs10807321 chr6:45330974 T/C cg20913747 chr6:44695427 NA -0.48 -7.8 -0.39 7.82e-14 Total body bone mineral density; LUSC cis rs208520 0.690 rs2126120 chr6:66742754 A/G cg07460842 chr6:66804631 NA 1.1 17.23 0.69 4.59e-48 Exhaled nitric oxide output; LUSC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.65e-13 Bipolar disorder; LUSC cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg15839431 chr19:19639596 YJEFN3 0.6 6.63 0.34 1.33e-10 Bipolar disorder; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.65 10.84 0.51 1.15e-23 Prudent dietary pattern; LUSC cis rs6674970 0.966 rs4512652 chr1:151115690 G/C cg11822372 chr1:151115635 SEMA6C 0.52 8.03 0.4 1.71e-14 Childhood ear infection; LUSC cis rs7829975 0.811 rs7011229 chr8:8543324 T/C cg06636001 chr8:8085503 FLJ10661 -0.53 -8.19 -0.41 5.46e-15 Mood instability; LUSC cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.03 0.36 1.14e-11 Rheumatoid arthritis; LUSC cis rs1866706 0.739 rs7116989 chr11:12856087 G/A cg25843174 chr11:12811716 TEAD1 -0.28 -5.69 -0.3 2.79e-8 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg17971929 chr21:40555470 PSMG1 0.8 14.05 0.61 1.48e-35 Cognitive function; LUSC cis rs2230307 0.536 rs534252 chr1:100472604 A/G cg24955406 chr1:100503596 HIAT1 0.56 6.04 0.31 4.01e-9 Carotid intima media thickness; LUSC cis rs9287719 0.901 rs10210859 chr2:10733929 C/T cg00105475 chr2:10696890 NA 0.37 6.17 0.32 1.99e-9 Prostate cancer; LUSC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg22535103 chr8:58192502 C8orf71 -0.61 -6.94 -0.36 1.99e-11 Developmental language disorder (linguistic errors); LUSC trans rs75804782 0.641 rs56134361 chr2:239318905 A/G cg01134436 chr17:81009848 B3GNTL1 0.64 6.08 0.32 3.37e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg11632617 chr15:75315747 PPCDC -0.51 -6.62 -0.34 1.46e-10 Blood trace element (Zn levels); LUSC cis rs7909074 1.000 rs4948926 chr10:45392604 G/C cg05187965 chr10:45406764 TMEM72 -0.38 -9.02 -0.44 1.47e-17 Mean corpuscular volume; LUSC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg11764359 chr7:65958608 NA 0.81 13.41 0.59 4.23e-33 Aortic root size; LUSC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg26958806 chr6:27640298 NA 0.68 5.76 0.3 1.93e-8 Depression; LUSC cis rs6582630 0.584 rs12832156 chr12:38419435 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.19 -0.41 5.43e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs11155671 0.530 rs7758020 chr6:150208111 T/C cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.15e-11 Testicular germ cell tumor; LUSC trans rs11039798 0.920 rs11040013 chr11:48782862 G/A cg03929089 chr4:120376271 NA 0.68 6.37 0.33 6.29e-10 Axial length; LUSC cis rs6060717 0.571 rs6060761 chr20:34612487 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.31 -0.33 8.76e-10 Hip circumference adjusted for BMI; LUSC cis rs8060686 0.641 rs12445396 chr16:68155121 G/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.35 -0.37 1.57e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs9888739 0.591 rs4632147 chr16:31363381 C/T cg15817542 chr16:31343056 ITGAM -0.53 -7.17 -0.37 4.82e-12 Systemic lupus erythematosus; LUSC trans rs17685 0.753 rs1104878 chr7:75685593 G/T cg19862616 chr7:65841803 NCRNA00174 1.12 19.83 0.74 2.22e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg11764359 chr7:65958608 NA -0.71 -11.04 -0.52 2.31e-24 Aortic root size; LUSC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs7208859 0.623 rs11650982 chr17:29129955 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4363385 0.720 rs1415967 chr1:152965585 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.66 -0.39 2.08e-13 Inflammatory skin disease; LUSC trans rs11098499 0.535 rs7671759 chr4:120248094 A/C cg25214090 chr10:38739885 LOC399744 0.45 6.77 0.35 5.65e-11 Corneal astigmatism; LUSC cis rs7914558 0.966 rs10748837 chr10:104880236 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.05 -0.36 1.05e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7819412 0.522 rs3021495 chr8:10994743 C/G cg21775007 chr8:11205619 TDH -0.53 -6.86 -0.35 3.37e-11 Triglycerides; LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03576123 chr11:487126 PTDSS2 -1.01 -10.64 -0.5 5.61e-23 Body mass index; LUSC cis rs1372520 0.564 rs2737011 chr4:90746219 T/C cg15133208 chr4:90757351 SNCA -0.51 -7.61 -0.38 2.85e-13 Neuroticism; LUSC cis rs10761482 0.500 rs2393644 chr10:62311274 T/A cg18175470 chr10:62150864 ANK3 -0.48 -6.81 -0.35 4.5e-11 Schizophrenia; LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.1 -0.58 6.18e-32 Platelet count; LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg13395646 chr4:1353034 KIAA1530 -0.66 -10.36 -0.49 5.61e-22 Obesity-related traits; LUSC cis rs2014572 0.967 rs11084492 chr19:57756026 A/T cg24459738 chr19:57751996 ZNF805 -0.52 -7.69 -0.39 1.66e-13 Hyperactive-impulsive symptoms; LUSC cis rs611744 0.573 rs629996 chr8:109255206 C/T cg18478394 chr8:109455254 TTC35 0.46 7.13 0.36 6.27e-12 Dupuytren's disease; LUSC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg06640241 chr16:89574553 SPG7 0.7 11.11 0.52 1.31e-24 Multiple myeloma (IgH translocation); LUSC cis rs6546550 0.933 rs1454498 chr2:70149225 C/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs425277 1.000 rs262667 chr1:2082722 T/C cg24578937 chr1:2090814 PRKCZ 0.6 13.79 0.6 1.46e-34 Height; LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg07703079 chr11:430292 ANO9 0.66 6.77 0.35 5.66e-11 Body mass index; LUSC cis rs2898290 0.578 rs34163377 chr8:11450213 C/G cg21775007 chr8:11205619 TDH 0.41 5.74 0.3 2.08e-8 Systolic blood pressure; LUSC cis rs6700896 0.931 rs1938492 chr1:66117829 A/C cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg08736216 chr1:53307985 ZYG11A 0.28 5.74 0.3 2.12e-8 Monocyte count; LUSC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.86e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs1215050 0.740 rs2695464 chr4:98980929 T/C cg03676636 chr4:99064102 C4orf37 -0.26 -5.65 -0.3 3.5e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9747201 0.862 rs57596657 chr17:80147978 C/T cg17462356 chr17:80056334 FASN -0.46 -6.21 -0.32 1.53e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.37 0.59 6.16e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9311676 0.632 rs56398717 chr3:58404355 G/A cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs10197940 0.624 rs17270233 chr2:152372420 A/G cg06191203 chr2:152266755 RIF1 -0.54 -7.28 -0.37 2.44e-12 Lung cancer; LUSC cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.49 7.69 0.39 1.71e-13 Colorectal cancer; LUSC cis rs9473147 0.516 rs2171089 chr6:47515811 A/G cg20196966 chr6:47445060 CD2AP 0.42 5.89 0.31 9.59e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg10609677 chr17:41278573 BRCA1;NBR2 0.36 5.86 0.31 1.09e-8 Menopause (age at onset); LUSC cis rs6456156 0.586 rs12198816 chr6:167483546 G/A cg06454157 chr6:167490870 NA -0.28 -6.58 -0.34 1.78e-10 Primary biliary cholangitis; LUSC cis rs929354 0.772 rs2051876 chr7:157009037 A/G cg05182265 chr7:156933206 UBE3C 0.6 9.91 0.48 1.78e-20 Body mass index; LUSC cis rs12541635 0.934 rs11776139 chr8:106983966 A/G cg10147462 chr8:107024639 NA 0.56 9.7 0.47 9.18e-20 Age of smoking initiation; LUSC cis rs55665837 1.000 rs12295888 chr11:14450531 T/C cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg18479299 chr3:125709523 NA -0.5 -5.7 -0.3 2.65e-8 Blood pressure (smoking interaction); LUSC cis rs7727544 0.606 rs17622208 chr5:131717050 G/A cg04518342 chr5:131593106 PDLIM4 0.34 6.03 0.31 4.47e-9 Blood metabolite levels; LUSC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg25251562 chr2:3704773 ALLC -0.54 -8.2 -0.41 5.24e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2224391 0.628 rs2773319 chr6:5258941 C/T cg09085698 chr6:5261316 LYRM4;FARS2 0.48 6.55 0.34 2.13e-10 Height; LUSC cis rs7580658 0.926 rs79789049 chr2:128145472 G/A cg09760422 chr2:128146352 NA -0.33 -7.25 -0.37 2.91e-12 Protein C levels; LUSC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.73 0.39 1.26e-13 Bipolar disorder; LUSC cis rs7590368 0.561 rs80325720 chr2:10958803 T/C cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs7789940 1.000 rs17149161 chr7:75978229 C/A cg15798862 chr7:76129360 DTX2 -0.51 -8.54 -0.42 4.77e-16 Multiple sclerosis; LUSC cis rs1371867 0.875 rs1619759 chr8:101337560 T/C cg06636551 chr8:101224915 SPAG1 -0.43 -7.82 -0.39 6.79e-14 Atrioventricular conduction; LUSC cis rs738321 0.701 rs4821754 chr22:38581503 A/G cg25457927 chr22:38595422 NA 0.44 8.08 0.4 1.18e-14 Breast cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01586524 chr8:67341819 RRS1 0.46 6.42 0.33 4.58e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs1541010 0.762 rs2015015 chr10:13766692 C/T cg04685003 chr17:57696515 CLTC -0.43 -6.26 -0.32 1.15e-9 RR interval (heart rate); LUSC cis rs11122272 0.735 rs2486746 chr1:231497324 C/T cg06096015 chr1:231504339 EGLN1 0.55 9.95 0.48 1.35e-20 Hemoglobin concentration; LUSC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg06740227 chr12:86229804 RASSF9 -0.36 -5.81 -0.3 1.43e-8 Major depressive disorder; LUSC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.1 -0.32 2.93e-9 Lung cancer; LUSC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs7712401 0.601 rs35699701 chr5:122333756 G/T cg19077854 chr5:122220652 SNX24 -0.43 -9.2 -0.45 4.07e-18 Mean platelet volume; LUSC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg14830002 chr1:247616686 OR2B11 0.52 7.47 0.38 7.16e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg05347473 chr6:146136440 FBXO30 0.39 6.49 0.33 3.16e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.67 -0.57 2.7e-30 Platelet count; LUSC cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg26384229 chr12:38710491 ALG10B -0.84 -15.9 -0.66 8.8e-43 Heart rate; LUSC cis rs202126107 1 rs202126107 chr17:38006767 GCATATTATA/G cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.9 0.31 8.87e-9 Eosinophil percentage of white cells; LUSC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs9951602 0.512 rs4799246 chr18:76653417 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs11098499 0.863 rs13140391 chr4:120503437 A/G cg09307838 chr4:120376055 NA 0.74 10.7 0.51 3.6e-23 Corneal astigmatism; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg22166914 chr1:53195759 ZYG11B 0.52 8.64 0.43 2.29e-16 Monocyte count; LUSC cis rs11252926 0.603 rs11252670 chr10:529152 A/G cg03684893 chr10:554711 DIP2C 0.38 7.03 0.36 1.18e-11 Psychosis in Alzheimer's disease; LUSC cis rs2439831 0.867 rs28461955 chr15:43661459 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.16 0.58 3.88e-32 Lung cancer in ever smokers; LUSC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg17143192 chr8:8559678 CLDN23 -0.65 -9.56 -0.46 2.6e-19 Obesity-related traits; LUSC cis rs4144743 1.000 rs72823473 chr17:45321775 A/T cg18085866 chr17:45331354 ITGB3 -0.75 -8.07 -0.4 1.24e-14 Body mass index; LUSC cis rs28647808 0.881 rs4962139 chr9:136267869 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A -0.67 -6.76 -0.35 6.29e-11 Blood protein levels; LUSC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg00509249 chr6:109615579 CCDC162 -0.34 -6.14 -0.32 2.36e-9 Reticulocyte fraction of red cells; LUSC cis rs7709377 0.595 rs149131 chr5:115639459 T/A cg23108291 chr5:115420582 COMMD10 -0.4 -5.65 -0.3 3.46e-8 Metabolite levels (X-11787); LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.32 0.53 2.26e-25 Menopause (age at onset); LUSC cis rs6496667 0.509 rs6496677 chr15:90990358 A/G cg22089800 chr15:90895588 ZNF774 0.52 7.46 0.38 7.52e-13 Rheumatoid arthritis; LUSC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg13902645 chr11:5959945 NA -0.53 -7.87 -0.4 5e-14 DNA methylation (variation); LUSC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg11764359 chr7:65958608 NA -0.78 -12.62 -0.57 4.11e-30 Aortic root size; LUSC cis rs7267979 1.000 rs2258201 chr20:25272490 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.44 0.75 8.43e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.52 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg24399712 chr22:39784796 NA -0.6 -10.85 -0.51 1.06e-23 Intelligence (multi-trait analysis); LUSC cis rs10887741 0.646 rs4934355 chr10:89425411 G/A cg13926569 chr10:89418898 PAPSS2 0.31 6.6 0.34 1.6e-10 Exercise (leisure time); LUSC cis rs9467773 0.526 rs9688946 chr6:26367445 C/A cg05738196 chr6:26577821 NA -0.47 -7.28 -0.37 2.42e-12 Intelligence (multi-trait analysis); LUSC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs2629540 0.889 rs4962696 chr10:126445630 A/G cg08799069 chr10:126477246 METTL10 -0.7 -10.56 -0.5 1.12e-22 Cocaine dependence; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.99 -15.21 -0.64 4.58e-40 Gut microbiome composition (summer); LUSC cis rs4975709 0.838 rs4975752 chr5:1880588 A/C cg20790798 chr5:1857306 NA -0.4 -6.02 -0.31 4.48e-9 Cardiovascular disease risk factors; LUSC cis rs1670533 0.932 rs3796620 chr4:1095079 A/G cg02018176 chr4:1364513 KIAA1530 -0.47 -6.59 -0.34 1.75e-10 Recombination rate (females); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14902356 chr20:10015648 ANKRD5 -0.41 -6.38 -0.33 5.76e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2180341 0.538 rs11154402 chr6:127711932 C/A cg27446573 chr6:127587934 RNF146 0.46 7.02 0.36 1.24e-11 Breast cancer; LUSC cis rs11122272 0.735 rs2437149 chr1:231490105 C/T cg06096015 chr1:231504339 EGLN1 0.56 9.93 0.48 1.52e-20 Hemoglobin concentration; LUSC cis rs2952156 1.000 rs2934967 chr17:37870378 G/A cg00129232 chr17:37814104 STARD3 -0.4 -5.83 -0.3 1.27e-8 Asthma; LUSC cis rs62458065 1.000 rs10250808 chr7:32466153 T/C cg20159608 chr7:32802032 NA -0.57 -7.01 -0.36 1.34e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs763121 0.853 rs138704 chr22:39133410 A/G cg06022373 chr22:39101656 GTPBP1 0.74 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC cis rs4494114 1.000 rs4494114 chr1:39339682 C/T cg25970120 chr1:39325951 RRAGC 0.43 6.86 0.35 3.26e-11 Blood protein levels; LUSC trans rs6561151 0.681 rs7989702 chr13:44439150 T/C cg12856521 chr11:46389249 DGKZ 0.75 9.65 0.47 1.36e-19 Crohn's disease; LUSC cis rs58804349 0.685 rs9422448 chr10:43288816 A/G cg08461752 chr10:43522343 NA -0.6 -6.1 -0.32 2.94e-9 Pediatric bone mineral content (radius); LUSC cis rs6543140 0.964 rs13390895 chr2:103075499 G/A cg09003973 chr2:102972529 NA 0.54 7.02 0.36 1.25e-11 Blood protein levels; LUSC cis rs12220238 1.000 rs10824101 chr10:75947438 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.58 6.69 0.34 9.3e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs62400317 0.859 rs62438863 chr6:45040592 C/T cg20913747 chr6:44695427 NA -0.46 -7.29 -0.37 2.3e-12 Total body bone mineral density; LUSC cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg13256891 chr4:100009986 ADH5 -0.53 -7.05 -0.36 1.01e-11 Smoking initiation; LUSC trans rs4665809 0.816 rs2384359 chr2:26371364 T/C cg19249749 chr1:223853145 CAPN8 -0.49 -5.95 -0.31 6.69e-9 Gut microbiome composition (summer); LUSC trans rs11098499 0.954 rs12502423 chr4:120424172 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.34 0.33 7.48e-10 Corneal astigmatism; LUSC cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg22467129 chr15:76604101 ETFA -0.4 -6.42 -0.33 4.79e-10 Blood metabolite levels; LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18440127 chr12:108155221 PRDM4 0.56 6.4 0.33 5.2e-10 Intelligence (multi-trait analysis); LUSC cis rs3008870 1.000 rs58680688 chr1:67443751 C/G cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.06 -0.64 1.78e-39 Lymphocyte percentage of white cells; LUSC cis rs73206853 0.620 rs73194038 chr12:111172339 G/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.67 0.34 1.08e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.39 0.53 1.32e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.01 0.31 4.73e-9 Menopause (age at onset); LUSC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.49 -6.93 -0.35 2.2e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg14552801 chr7:65878734 NA 0.39 6.07 0.32 3.46e-9 Aortic root size; LUSC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg06640241 chr16:89574553 SPG7 0.73 11.96 0.55 1.12e-27 Multiple myeloma (IgH translocation); LUSC cis rs2279817 1.000 rs10788681 chr1:18019524 C/A cg21791023 chr1:18019539 ARHGEF10L 0.5 7.07 0.36 9.03e-12 Neuroticism; LUSC cis rs7568458 0.684 rs67988001 chr2:85787123 C/T cg23752985 chr2:85803571 VAMP8 0.34 6.55 0.34 2.21e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg18225595 chr11:63971243 STIP1 0.5 6.13 0.32 2.48e-9 Mean platelet volume; LUSC cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg25817165 chr18:72167213 CNDP2 -0.75 -11.17 -0.52 8.07e-25 Refractive error; LUSC cis rs6546550 0.935 rs7563062 chr2:70050725 G/A cg02498382 chr2:70120550 SNRNP27 -0.29 -7.11 -0.36 7.2e-12 Prevalent atrial fibrillation; LUSC cis rs240764 0.604 rs705583 chr6:101261408 C/A cg09795085 chr6:101329169 ASCC3 0.44 6.54 0.34 2.34e-10 Neuroticism; LUSC cis rs8031584 0.918 rs35396566 chr15:31263057 T/C cg14829155 chr15:31115871 NA -0.65 -8.78 -0.43 8.92e-17 Huntington's disease progression; LUSC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg06238570 chr21:40685208 BRWD1 0.59 9.92 0.48 1.75e-20 Cognitive function; LUSC cis rs9875589 0.509 rs2607757 chr3:14081948 A/G cg19554555 chr3:13937349 NA 0.4 6.14 0.32 2.39e-9 Ovarian reserve; LUSC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg18350739 chr11:68623251 NA -0.38 -6.87 -0.35 3.16e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs3947 0.906 rs1692821 chr8:11699988 C/T cg00262122 chr8:11665843 FDFT1 -0.56 -7.5 -0.38 5.87e-13 Blood protein levels; LUSC cis rs6840360 0.642 rs1470280 chr4:152431770 C/T cg20465933 chr4:152376761 FAM160A1 0.33 5.94 0.31 7.12e-9 Intelligence (multi-trait analysis); LUSC cis rs4076764 0.801 rs4571944 chr1:163367975 T/C cg06092702 chr1:163392909 NA -0.39 -6.67 -0.34 1.09e-10 Motion sickness; LUSC cis rs8062405 0.755 rs4788080 chr16:28558081 C/T cg16576597 chr16:28551801 NUPR1 0.34 6.73 0.35 7.35e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg03517284 chr6:25882590 NA 0.53 10.21 0.49 1.74e-21 Blood metabolite levels; LUSC cis rs3768617 0.510 rs10911242 chr1:183072147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.58 0.5 9.32e-23 Fuchs's corneal dystrophy; LUSC cis rs7927592 0.513 rs607887 chr11:68196961 C/T cg20283391 chr11:68216788 NA -0.5 -7.17 -0.37 4.79e-12 Total body bone mineral density; LUSC cis rs6087990 0.835 rs4911106 chr20:31331330 A/G cg13636640 chr20:31349939 DNMT3B 0.98 21.42 0.76 1.15e-64 Ulcerative colitis; LUSC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.02 0.36 1.21e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg01073479 chr16:3509474 NAT15 0.44 5.77 0.3 1.85e-8 Tuberculosis; LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg24829409 chr8:58192753 C8orf71 -0.5 -6.1 -0.32 2.86e-9 Developmental language disorder (linguistic errors); LUSC cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg24812749 chr6:127587940 RNF146 0.81 11.81 0.54 3.95e-27 Breast cancer; LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg07703079 chr11:430292 ANO9 0.58 6.41 0.33 4.99e-10 Body mass index; LUSC cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg02175503 chr12:58329896 NA 0.57 8.74 0.43 1.14e-16 Intelligence (multi-trait analysis); LUSC cis rs6967385 0.580 rs6962273 chr7:12330166 G/C cg06484146 chr7:12443880 VWDE 0.41 6.52 0.34 2.56e-10 Response to taxane treatment (placlitaxel); LUSC trans rs7618501 0.602 rs2245365 chr3:50097319 C/A cg21659725 chr3:3221576 CRBN -0.64 -10.61 -0.5 7.4e-23 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg05347473 chr6:146136440 FBXO30 0.48 7.89 0.4 4.3e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7592578 0.771 rs4439990 chr2:191398353 A/C cg11845111 chr2:191398756 TMEM194B -0.88 -11.28 -0.53 3.28e-25 Diastolic blood pressure; LUSC cis rs644799 0.672 rs61902245 chr11:95517737 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.84 14.11 0.61 9.1e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10256972 0.630 rs10282584 chr7:1081442 C/T cg00431813 chr7:1051703 C7orf50 -0.56 -9.99 -0.48 1.01e-20 Longevity;Endometriosis; LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.44e-12 Bipolar disorder; LUSC cis rs3736594 0.513 rs56725354 chr2:27824168 G/C cg27432699 chr2:27873401 GPN1 0.65 8.74 0.43 1.17e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg22875332 chr1:76189707 ACADM 0.76 10.36 0.49 5.53e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg03433033 chr1:76189801 ACADM 0.82 14.75 0.63 2.93e-38 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7223966 0.883 rs2955250 chr17:61959740 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.17 0.37 4.83e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9581857 0.579 rs3759433 chr13:27997999 C/T cg22138327 chr13:27999177 GTF3A 0.83 10.88 0.51 8.38e-24 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.75 0.77 5.71e-66 Prudent dietary pattern; LUSC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg25208724 chr1:156163844 SLC25A44 1.1 26.31 0.82 2.03e-83 Testicular germ cell tumor; LUSC cis rs9815354 0.812 rs55788971 chr3:41843965 T/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9393777 0.623 rs9358945 chr6:26472114 C/T cg12826209 chr6:26865740 GUSBL1 -0.64 -7.3 -0.37 2.15e-12 Intelligence (multi-trait analysis); LUSC trans rs3733585 0.673 rs4459990 chr4:9954005 T/C cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1419980 0.643 rs10845600 chr12:7796463 C/T cg10578777 chr12:7781093 NA -0.62 -5.76 -0.3 1.88e-8 HDL cholesterol levels; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg03188948 chr7:1209495 NA 0.66 7.09 0.36 8.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10754283 0.967 rs7515375 chr1:90109854 T/C cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs208520 0.690 rs12198745 chr6:66722598 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.06 16.41 0.67 8.89e-45 Exhaled nitric oxide output; LUSC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg13298116 chr11:62369859 EML3;MTA2 0.59 9.55 0.46 2.9e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs10098647 0.632 rs28689904 chr8:61111338 T/A cg09970348 chr3:183978600 ECE2;CAMK2N2 0.46 6.15 0.32 2.26e-9 Obesity-related traits; LUSC cis rs4474465 0.790 rs6592790 chr11:78262618 T/C cg27205649 chr11:78285834 NARS2 0.53 6.45 0.33 4.02e-10 Alzheimer's disease (survival time); LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2280018 0.526 rs2941257 chr16:15166445 T/C cg27102117 chr16:15229624 NA 0.53 8.21 0.41 4.81e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg18350739 chr11:68623251 NA -0.38 -6.77 -0.35 5.88e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1048238 0.506 rs10927867 chr1:16177285 A/G cg22431228 chr1:16359049 CLCNKA -0.41 -8.22 -0.41 4.47e-15 Systolic blood pressure; LUSC cis rs4891159 0.790 rs72975925 chr18:74143902 G/A cg24786174 chr18:74118243 ZNF516 -0.83 -15.1 -0.64 1.23e-39 Longevity; LUSC cis rs6089584 0.927 rs11697597 chr20:60584748 C/T cg23262073 chr20:60523788 NA -0.42 -6.09 -0.32 3.18e-9 Body mass index; LUSC cis rs3799379 0.530 rs10456045 chr6:26404958 A/G cg12826209 chr6:26865740 GUSBL1 -0.46 -6.1 -0.32 2.85e-9 Intelligence (multi-trait analysis); LUSC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg03709012 chr19:19516395 GATAD2A 0.76 11.7 0.54 1e-26 Tonsillectomy; LUSC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg22800045 chr5:56110881 MAP3K1 0.45 6.03 0.31 4.3e-9 Coronary artery disease; LUSC cis rs11048434 0.736 rs1805732 chr12:9090892 A/G cg13575925 chr12:9217583 LOC144571 -0.33 -6.03 -0.31 4.37e-9 Sjögren's syndrome; LUSC cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.65 9.51 0.46 3.79e-19 Menarche (age at onset); LUSC cis rs67072384 0.818 rs2291291 chr11:72466897 T/C cg04827223 chr11:72435913 ARAP1 -0.74 -6.42 -0.33 4.6e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg13607699 chr17:42295918 UBTF -0.53 -8.18 -0.41 6.11e-15 Total body bone mineral density; LUSC cis rs7954584 0.583 rs6486782 chr12:122359172 T/C cg13699009 chr12:122356056 WDR66 0.45 6.79 0.35 5e-11 Mean corpuscular volume; LUSC cis rs11112613 0.609 rs11112636 chr12:106047204 G/A cg03607813 chr12:105948248 NA 0.62 7.7 0.39 1.51e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs2404602 0.684 rs10851888 chr15:76902506 C/T cg23625390 chr15:77176239 SCAPER -0.65 -9.66 -0.47 1.26e-19 Blood metabolite levels; LUSC cis rs1371867 0.875 rs1660344 chr8:101324659 A/G cg06636551 chr8:101224915 SPAG1 -0.46 -8.33 -0.41 2.19e-15 Atrioventricular conduction; LUSC cis rs2137920 0.891 rs2254754 chr10:50235335 G/A cg27141751 chr10:50231850 C10orf72 0.38 5.75 0.3 1.98e-8 Migraine with aura; LUSC cis rs80130819 0.748 rs2732446 chr12:48690177 T/C cg24011408 chr12:48396354 COL2A1 0.46 5.88 0.31 9.77e-9 Prostate cancer; LUSC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg14552801 chr7:65878734 NA -0.48 -6.65 -0.34 1.18e-10 Aortic root size; LUSC cis rs11229555 0.645 rs35735990 chr11:58187371 G/A cg15696309 chr11:58395628 NA -0.64 -7.78 -0.39 9.19e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1997103 1.000 rs10249105 chr7:55412405 A/G cg17469321 chr7:55412551 NA -0.66 -10.8 -0.51 1.6e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg19318889 chr4:1322082 MAEA 0.46 7.37 0.37 1.32e-12 Obesity-related traits; LUSC cis rs701145 0.938 rs701138 chr3:154063609 T/C cg17054900 chr3:154042577 DHX36 0.79 8.25 0.41 3.74e-15 Coronary artery disease; LUSC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.02 0.36 1.21e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg00152838 chr16:24741724 TNRC6A -0.48 -6.03 -0.31 4.26e-9 Intelligence (multi-trait analysis); LUSC cis rs7296418 0.961 rs12425850 chr12:123501972 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -7.17 -0.37 4.8e-12 Platelet count; LUSC cis rs8017423 0.967 rs59006192 chr14:90706456 C/T cg04374321 chr14:90722782 PSMC1 0.73 11.56 0.53 3.22e-26 Mortality in heart failure; LUSC cis rs5997397 0.967 rs5762777 chr22:29150044 T/C cg02153584 chr22:29168773 CCDC117 0.44 6.68 0.34 1.01e-10 Red cell distribution width; LUSC cis rs2742234 0.518 rs2505514 chr10:43633248 A/G cg15436174 chr10:43711423 RASGEF1A -0.43 -7.15 -0.36 5.41e-12 Hirschsprung disease; LUSC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg02423579 chr7:2872169 GNA12 -0.43 -6.18 -0.32 1.89e-9 Height; LUSC cis rs7712401 0.791 rs1531340 chr5:122108017 G/A cg19077854 chr5:122220652 SNX24 0.35 7.73 0.39 1.25e-13 Mean platelet volume; LUSC cis rs7804356 1.000 rs73069510 chr7:26877567 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.58e-9 Type 1 diabetes; LUSC cis rs11098499 0.863 rs3822195 chr4:120471660 C/T cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC trans rs724744 0.660 rs1737233 chr6:22351805 T/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.15 -0.32 2.18e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg00321850 chr1:175162397 KIAA0040 0.45 7.78 0.39 9.36e-14 Alcohol dependence; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg19983627 chr4:108852959 CYP2U1 -0.53 -7.01 -0.36 1.3e-11 Cognitive function;Information processing speed; LUSC cis rs11250098 0.567 rs4326350 chr8:10763655 C/G cg21775007 chr8:11205619 TDH 0.52 7.09 0.36 8.23e-12 Morning vs. evening chronotype; LUSC cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg11244672 chr19:19639970 YJEFN3 0.57 7.25 0.37 2.99e-12 Bipolar disorder; LUSC cis rs2625529 0.938 rs2742323 chr15:72116778 A/T cg16672083 chr15:72433130 SENP8 0.52 7.62 0.38 2.64e-13 Red blood cell count; LUSC cis rs2078087 0.831 rs58734925 chr1:183234177 A/G cg13843938 chr1:183241246 NMNAT2 0.44 5.89 0.31 9.45e-9 Obesity-related traits; LUSC cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg05855489 chr10:104503620 C10orf26 0.58 8.73 0.43 1.24e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg05585544 chr11:47624801 NA -0.41 -7.09 -0.36 7.89e-12 Subjective well-being; LUSC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs12200560 0.505 rs984520 chr6:97076454 A/G cg06623918 chr6:96969491 KIAA0776 -0.49 -7.1 -0.36 7.33e-12 Coronary heart disease; LUSC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg08008072 chr16:1524255 CLCN7 0.66 14.46 0.62 3.92e-37 Bone mineral density; LUSC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg05313129 chr8:58192883 C8orf71 -0.54 -6.03 -0.31 4.37e-9 Developmental language disorder (linguistic errors); LUSC cis rs6121246 0.738 rs6121242 chr20:30410877 T/C cg18721089 chr20:30220636 NA -0.36 -6.15 -0.32 2.17e-9 Mean corpuscular hemoglobin; LUSC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg05585544 chr11:47624801 NA -0.42 -7.46 -0.38 7.63e-13 Subjective well-being; LUSC cis rs6424115 1.000 rs6697805 chr1:24151996 C/A cg10978503 chr1:24200527 CNR2 -0.49 -11.52 -0.53 4.41e-26 Immature fraction of reticulocytes; LUSC cis rs6961069 0.585 rs2691199 chr7:80239666 T/C cg04458919 chr7:80252533 CD36 -0.4 -7.32 -0.37 1.91e-12 Platelet count; LUSC cis rs7824557 0.583 rs2263512 chr8:11233419 T/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.75 -0.3 2e-8 Retinal vascular caliber; LUSC cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg08807101 chr21:30365312 RNF160 0.79 14.9 0.63 7.27e-39 Dental caries; LUSC cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg23788917 chr6:8435910 SLC35B3 0.51 7.56 0.38 3.85e-13 Motion sickness; LUSC cis rs12541635 0.934 rs60482457 chr8:106970504 A/G cg10147462 chr8:107024639 NA 0.55 9.79 0.47 4.53e-20 Age of smoking initiation; LUSC cis rs11764590 0.694 rs11762413 chr7:2090387 C/G cg02825527 chr7:2087843 MAD1L1 -0.45 -5.84 -0.3 1.23e-8 Neuroticism; LUSC cis rs614226 1.000 rs1614223 chr12:120964043 T/C cg01236616 chr12:121019343 POP5 1.31 21.86 0.77 2.15e-66 Type 1 diabetes nephropathy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25116269 chr2:55509523 PRDXDD1P 0.42 6.55 0.34 2.2e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.61 9.03 0.44 1.42e-17 Menarche (age at onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03012876 chr2:179315436 PRKRA;MIR548N;DFNB59 -0.41 -6.26 -0.32 1.18e-9 Hepatitis; LUSC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg11742103 chr11:62369870 EML3;MTA2 0.55 8.95 0.44 2.48e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg18876405 chr7:65276391 NA 0.67 11.95 0.55 1.2100000000000001e-27 Aortic root size; LUSC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg23719950 chr11:63933701 MACROD1 -0.6 -7.63 -0.39 2.42e-13 Mean platelet volume; LUSC cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.8 -0.54 4.25e-27 Mean corpuscular volume; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg06544376 chr20:18548101 LOC388789 0.38 6.36 0.33 6.61e-10 Educational attainment (years of education); LUSC cis rs6500602 0.647 rs3747600 chr16:4586222 A/G cg08645402 chr16:4508243 NA 0.5 8.69 0.43 1.64e-16 Schizophrenia; LUSC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg18512352 chr11:47633146 NA -0.48 -9.63 -0.47 1.52e-19 Subjective well-being; LUSC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg16680214 chr1:154839983 KCNN3 -0.54 -10.1 -0.48 4.04e-21 Prostate cancer; LUSC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg07677032 chr17:61819896 STRADA -0.52 -8.51 -0.42 5.9e-16 Prudent dietary pattern; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg15695626 chr1:44445202 B4GALT2 0.45 5.94 0.31 6.98e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7512552 0.525 rs2298161 chr1:150237624 A/G cg15654264 chr1:150340011 RPRD2 0.44 7.04 0.36 1.13e-11 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg03734322 chr17:1532856 SLC43A2 0.46 6.09 0.32 3.08e-9 Cognitive function;Information processing speed; LUSC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg20933634 chr6:27740509 NA 0.44 6.28 0.33 1.04e-9 Parkinson's disease; LUSC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg08917208 chr2:24149416 ATAD2B 0.56 6.27 0.32 1.14e-9 Lymphocyte counts; LUSC cis rs6939532 0.522 rs4712981 chr6:26361430 C/T cg09904177 chr6:26538194 HMGN4 -0.46 -6.68 -0.34 9.75e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1957429 0.808 rs763346 chr14:65330386 A/G cg23373153 chr14:65346875 NA -0.95 -10.82 -0.51 1.34e-23 Pediatric areal bone mineral density (radius); LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs1814175 0.765 rs1721990 chr11:49912154 G/C cg15704280 chr7:45808275 SEPT13 -1.13 -24.62 -0.8 4.6e-77 Height; LUSC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg08798685 chr6:27730294 NA -0.63 -5.94 -0.31 7.28e-9 Depression; LUSC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs7617773 0.817 rs9837228 chr3:48324466 A/T cg20734569 chr3:48348370 SPINK8 0.47 8.35 0.42 1.82e-15 Coronary artery disease; LUSC cis rs1018836 0.828 rs7012741 chr8:91536065 A/G cg16814680 chr8:91681699 NA -0.68 -10.65 -0.5 5.16e-23 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4268898 0.722 rs11691212 chr2:24404733 A/G cg06627628 chr2:24431161 ITSN2 0.55 7.94 0.4 3.06e-14 Asthma; LUSC cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC cis rs9911578 0.842 rs12450766 chr17:56832965 G/C cg12560992 chr17:57184187 TRIM37 -0.76 -12.11 -0.55 3.11e-28 Intelligence (multi-trait analysis); LUSC cis rs73198271 0.640 rs7838012 chr8:8656630 A/G cg01851573 chr8:8652454 MFHAS1 0.47 7.74 0.39 1.22e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3008870 0.755 rs1535365 chr1:67497613 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.37 0.56 3.48e-29 Lymphocyte percentage of white cells; LUSC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg18404041 chr3:52824283 ITIH1 -0.62 -11.92 -0.55 1.52e-27 Bipolar disorder; LUSC cis rs2742540 0.503 rs11042121 chr11:8932640 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.34 5.96 0.31 6.35e-9 Hematocrit; LUSC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.19 -0.41 5.46e-15 Personality dimensions; LUSC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.07e-19 Colonoscopy-negative controls vs population controls; LUSC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21659725 chr3:3221576 CRBN 0.85 16.25 0.66 3.65e-44 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.681 rs1095386 chr15:43609509 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.91 11.06 0.52 2e-24 Lung cancer in ever smokers; LUSC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg09165964 chr15:75287851 SCAMP5 0.48 7.13 0.36 6.18e-12 Breast cancer; LUSC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs3862435 0.518 rs2601169 chr15:90913890 T/C cg22089800 chr15:90895588 ZNF774 0.57 6.12 0.32 2.56e-9 Response to exercise (triglyceride level interaction); LUSC cis rs62400317 0.762 rs9367210 chr6:44863395 G/A cg20913747 chr6:44695427 NA -0.48 -7.44 -0.38 8.79e-13 Total body bone mineral density; LUSC cis rs12594515 1.000 rs56220882 chr15:45997075 C/G cg19682013 chr15:45996608 NA 0.38 5.77 0.3 1.8e-8 Waist circumference;Weight; LUSC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg12560992 chr17:57184187 TRIM37 0.85 15.26 0.64 3e-40 Intelligence (multi-trait analysis); LUSC cis rs798766 1.000 rs798766 chr4:1734239 C/T cg05874882 chr4:1763078 NA 0.53 8.36 0.42 1.75e-15 Bladder cancer;Urinary bladder cancer; LUSC cis rs3849570 0.961 rs3821548 chr3:81758728 C/G cg07356753 chr3:81810745 GBE1 -0.69 -11.08 -0.52 1.72e-24 Waist circumference;Body mass index; LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 13.5 0.59 1.91e-33 Platelet count; LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg00149659 chr3:10157352 C3orf10 0.9 11.91 0.55 1.63e-27 Alzheimer's disease; LUSC cis rs6964587 0.967 rs2040499 chr7:91809657 C/G cg17063962 chr7:91808500 NA -0.57 -9.57 -0.46 2.45e-19 Breast cancer; LUSC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg09783858 chr11:65769428 EIF1AD;BANF1 0.43 6.16 0.32 2.14e-9 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19747852 chr7:23571693 TRA2A -0.41 -5.97 -0.31 6.15e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9300255 0.602 rs1626899 chr12:123708063 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg05110241 chr16:68378359 PRMT7 -0.55 -6.36 -0.33 6.78e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg20821713 chr7:1055600 C7orf50 -0.46 -7.58 -0.38 3.44e-13 Longevity;Endometriosis; LUSC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.69 0.63 5.12e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs929354 0.772 rs1182432 chr7:157029176 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.42 0.59 3.94e-33 Body mass index; LUSC cis rs7119038 0.818 rs10892289 chr11:118646003 C/T cg19308663 chr11:118741387 NA 0.37 6.33 0.33 7.82e-10 Sjögren's syndrome; LUSC cis rs4555082 0.874 rs28625632 chr14:105748849 G/T cg13114125 chr14:105738426 BRF1 -0.91 -14.92 -0.63 6.02e-39 Mean platelet volume;Platelet distribution width; LUSC cis rs1832871 1.000 rs827864 chr6:158711023 A/G cg07165851 chr6:158734300 TULP4 0.37 6.37 0.33 6.31e-10 Height; LUSC cis rs8141529 0.764 rs5752807 chr22:29223169 A/G cg02153584 chr22:29168773 CCDC117 0.66 10.6 0.5 8.09e-23 Lymphocyte counts; LUSC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg06697600 chr4:7070879 GRPEL1 0.36 5.77 0.3 1.76e-8 Monocyte percentage of white cells; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg13685833 chr1:53393034 SCP2 -0.41 -6.32 -0.33 8.23e-10 Monocyte count; LUSC cis rs116988415 0.584 rs4902314 chr14:65254415 T/C cg25083366 chr14:65239357 SPTB 0.66 6.81 0.35 4.41e-11 Daytime sleep phenotypes; LUSC cis rs394563 0.625 rs384306 chr6:149796140 A/G cg07828024 chr6:149772892 ZC3H12D -0.38 -7.89 -0.4 4.39e-14 Dupuytren's disease; LUSC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg23791538 chr6:167370224 RNASET2 -0.37 -5.72 -0.3 2.38e-8 Crohn's disease; LUSC cis rs709400 0.827 rs2274269 chr14:104029246 G/A cg24130564 chr14:104152367 KLC1 -0.47 -6.69 -0.34 9.23e-11 Body mass index; LUSC cis rs7618501 1.000 rs7618519 chr3:49772708 A/T cg12257692 chr3:49977190 RBM6 -0.21 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); LUSC cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg08213375 chr14:104286397 PPP1R13B 0.48 8.55 0.42 4.38e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs12579753 1.000 rs12366580 chr12:82222784 G/A cg21231944 chr12:82153410 PPFIA2 -0.39 -5.91 -0.31 8.57e-9 Resting heart rate; LUSC cis rs3824867 0.920 rs9919526 chr11:47451623 C/T cg20307385 chr11:47447363 PSMC3 -0.64 -9.52 -0.46 3.67e-19 Mean corpuscular hemoglobin; LUSC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.4 6.06 0.31 3.59e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg25456477 chr12:86230367 RASSF9 0.36 6.42 0.33 4.55e-10 Major depressive disorder; LUSC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg03433033 chr1:76189801 ACADM 0.75 10.76 0.51 2.18e-23 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs3960554 0.808 rs78478514 chr7:75655896 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 9.66 0.47 1.22e-19 Eotaxin levels; LUSC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg20203395 chr5:56204925 C5orf35 -0.56 -8.0 -0.4 2.07e-14 Coronary artery disease; LUSC cis rs9296092 0.500 rs9469503 chr6:33527234 G/T cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2425143 0.908 rs75331436 chr20:34391052 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.71 -0.3 2.51e-8 Blood protein levels; LUSC cis rs7903847 0.642 rs1537646 chr10:99149922 T/C cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.26e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs41271473 0.526 rs2182202 chr1:228733959 G/C cg16512390 chr1:228756714 NA 0.7 8.89 0.44 4.03e-17 Chronic lymphocytic leukemia; LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg21782813 chr7:2030301 MAD1L1 0.41 6.79 0.35 5.2e-11 Bipolar disorder and schizophrenia; LUSC cis rs9807989 0.839 rs10206753 chr2:102968362 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs3808502 0.585 rs4549730 chr8:11239078 T/G cg21775007 chr8:11205619 TDH -0.64 -10.41 -0.49 3.61e-22 Neuroticism; LUSC cis rs757081 0.667 rs3950680 chr11:17138666 G/A cg15432903 chr11:17409602 KCNJ11 -0.39 -6.1 -0.32 2.97e-9 Systolic blood pressure; LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg22963979 chr7:1858916 MAD1L1 -0.58 -9.03 -0.44 1.39e-17 Bipolar disorder and schizophrenia; LUSC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11644478 chr21:40555479 PSMG1 0.65 10.78 0.51 1.87e-23 Cognitive function; LUSC trans rs9650657 0.645 rs4841408 chr8:10516336 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.1 -0.36 7.61e-12 Neuroticism; LUSC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg13114125 chr14:105738426 BRF1 -0.93 -16.05 -0.66 2.2e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs701145 0.585 rs401162 chr3:153905988 T/A cg17054900 chr3:154042577 DHX36 0.68 6.76 0.35 5.99e-11 Coronary artery disease; LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.29 0.33 9.92e-10 Menopause (age at onset); LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg26304593 chr6:42947056 PEX6 -0.52 -8.28 -0.41 3.03e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9640161 0.830 rs12703061 chr7:150062545 T/C cg27494647 chr7:150038898 RARRES2 0.44 6.76 0.35 6.18e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs17401966 0.838 rs11579365 chr1:10470846 G/T cg19773385 chr1:10388646 KIF1B -0.5 -8.9 -0.44 3.59e-17 Hepatocellular carcinoma; LUSC cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.26 -0.41 3.56e-15 Neuroticism; LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg19318889 chr4:1322082 MAEA 0.77 14.5 0.62 2.69e-37 Longevity; LUSC cis rs155346 1.000 rs265159 chr5:139390752 A/G cg01090482 chr5:139365336 NRG2 -0.38 -6.5 -0.34 2.87e-10 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07030052 chr1:162531143 UAP1 -0.34 -5.98 -0.31 5.67e-9 Electrocardiographic conduction measures; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.54 0.53 3.87e-26 Prudent dietary pattern; LUSC cis rs11756438 0.547 rs1343287 chr6:119001805 T/C cg21191810 chr6:118973309 C6orf204 0.34 5.81 0.3 1.46e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg02175503 chr12:58329896 NA 0.58 8.82 0.43 6.64e-17 Intelligence (multi-trait analysis); LUSC cis rs6961069 0.609 rs7789369 chr7:80226147 A/C cg04458919 chr7:80252533 CD36 -0.4 -7.17 -0.37 4.75e-12 Platelet count; LUSC trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg15704280 chr7:45808275 SEPT13 0.88 12.81 0.57 7.75e-31 Coronary artery disease; LUSC cis rs11250464 0.804 rs11250463 chr10:1406228 T/C cg26394196 chr10:1453818 ADARB2 -0.39 -6.73 -0.35 7.37e-11 Radiation response; LUSC cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg15839431 chr19:19639596 YJEFN3 -0.66 -7.28 -0.37 2.39e-12 Bipolar disorder; LUSC cis rs7208859 0.623 rs78071511 chr17:29128154 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs12579753 1.000 rs34031374 chr12:82235615 G/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg24692254 chr21:30365293 RNF160 0.77 12.87 0.58 4.61e-31 Selective IgA deficiency; LUSC cis rs13223928 0.651 rs4722435 chr7:3152962 C/T cg19214707 chr7:3157722 NA 0.45 9.11 0.45 7.55e-18 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs3087591 0.960 rs11080146 chr17:29578724 C/T cg24425628 chr17:29625626 OMG;NF1 -0.58 -8.48 -0.42 7.37e-16 Hip circumference; LUSC cis rs9517302 0.615 rs7983522 chr13:99098055 C/T cg22223119 chr13:99095684 FARP1 -0.66 -9.58 -0.46 2.22e-19 Obesity-related traits; LUSC cis rs9467773 1.000 rs9467783 chr6:26542894 C/T cg11502198 chr6:26597334 ABT1 0.59 9.21 0.45 3.63e-18 Intelligence (multi-trait analysis); LUSC cis rs2370759 1.000 rs16933225 chr10:32599464 C/T cg01819863 chr10:32635814 EPC1 1.03 12.73 0.57 1.59e-30 Sexual dysfunction (female); LUSC cis rs36093844 0.800 rs59179556 chr11:85573897 A/G cg25872744 chr11:85566296 CCDC83 -0.45 -5.78 -0.3 1.69e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs800082 0.671 rs800099 chr3:144398547 A/T cg24215973 chr2:240111563 HDAC4 -0.71 -10.4 -0.49 3.8e-22 Smoking behavior; LUSC trans rs11098499 0.909 rs28793658 chr4:120307214 A/C cg25214090 chr10:38739885 LOC399744 0.55 8.02 0.4 1.87e-14 Corneal astigmatism; LUSC trans rs72674100 1.000 rs55633486 chr4:97984679 A/G cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg02187348 chr16:89574699 SPG7 -0.39 -5.83 -0.3 1.31e-8 Multiple myeloma (IgH translocation); LUSC cis rs10489202 0.683 rs2294817 chr1:168073601 C/A cg24449463 chr1:168025552 DCAF6 -0.65 -9.73 -0.47 7.4e-20 Schizophrenia; LUSC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg15704280 chr7:45808275 SEPT13 -0.99 -16.58 -0.67 1.75e-45 Coronary artery disease; LUSC trans rs2243480 0.901 rs2456483 chr7:65461575 T/C cg10756647 chr7:56101905 PSPH 0.85 8.28 0.41 3.01e-15 Diabetic kidney disease; LUSC cis rs2898681 0.519 rs7670068 chr4:53733984 T/G cg21521518 chr4:53727714 RASL11B 0.43 5.77 0.3 1.79e-8 Optic nerve measurement (cup area); LUSC cis rs10740039 0.804 rs10761531 chr10:62397935 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs7746199 0.736 rs13215275 chr6:27647509 G/T cg01620082 chr3:125678407 NA -0.77 -6.9 -0.35 2.57e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs6977940 0.818 rs73033460 chr7:2900662 C/T cg19731401 chr7:2775893 GNA12 0.66 7.79 0.39 8.55e-14 White matter integrity; LUSC cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.39 0.46 1e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg03354898 chr7:1950403 MAD1L1 -0.31 -6.17 -0.32 2e-9 Bipolar disorder and schizophrenia; LUSC cis rs11048434 0.736 rs11048264 chr12:9113581 C/T cg23795048 chr12:9217529 LOC144571 -0.33 -6.1 -0.32 2.91e-9 Sjögren's syndrome; LUSC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg09021430 chr5:549028 NA -0.53 -7.49 -0.38 6.08e-13 Lung disease severity in cystic fibrosis; LUSC cis rs13315871 0.929 rs13077539 chr3:58267846 T/C cg12435725 chr3:58293450 RPP14 -0.78 -7.71 -0.39 1.45e-13 Cholesterol, total; LUSC cis rs9487051 1.000 rs6568571 chr6:109613252 A/T cg01475377 chr6:109611718 NA -0.41 -7.26 -0.37 2.81e-12 Reticulocyte fraction of red cells; LUSC cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg24642439 chr20:33292090 TP53INP2 0.75 12.38 0.56 3.14e-29 Coronary artery disease; LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18758796 chr5:131593413 PDLIM4 0.47 7.59 0.38 3.13e-13 Acylcarnitine levels; LUSC cis rs362272 0.505 rs3129310 chr4:3301388 T/G cg00810483 chr4:3375144 RGS12 0.3 5.7 0.3 2.58e-8 Serum sulfate level; LUSC cis rs2274273 0.905 rs8007620 chr14:55586587 T/C cg04306507 chr14:55594613 LGALS3 0.51 11.08 0.52 1.65e-24 Protein biomarker; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04868132 chr11:65265060 MALAT1 -0.42 -6.26 -0.32 1.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7833790 0.777 rs6473301 chr8:82691340 A/G cg27398817 chr8:82754497 SNX16 -0.65 -8.09 -0.4 1.09e-14 Diastolic blood pressure; LUSC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg20243544 chr17:37824526 PNMT 0.49 6.87 0.35 3.17e-11 Asthma; LUSC cis rs5769765 0.505 rs4561759 chr22:50256686 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.62 6.55 0.34 2.16e-10 Schizophrenia; LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg01802117 chr1:53393560 SCP2 -0.37 -6.31 -0.33 8.86e-10 Monocyte count; LUSC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.37 0.33 6.27e-10 Lung cancer; LUSC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg27432699 chr2:27873401 GPN1 -0.57 -8.49 -0.42 6.77e-16 Total body bone mineral density; LUSC cis rs847577 0.609 rs17435590 chr7:97784061 T/C cg21770322 chr7:97807741 LMTK2 0.57 10.37 0.49 5.03e-22 Breast cancer; LUSC trans rs11098499 0.863 rs11098531 chr4:120465001 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.83 0.35 3.91e-11 Corneal astigmatism; LUSC cis rs9660992 0.710 rs1151787 chr1:205254238 G/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.46 -0.46 5.68e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg17366294 chr4:99064904 C4orf37 0.54 8.76 0.43 1.01e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg09877947 chr5:131593287 PDLIM4 0.46 7.07 0.36 8.9e-12 Breast cancer; LUSC cis rs12210905 0.925 rs72838245 chr6:26987316 A/C cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg00961166 chr12:50236992 BCDIN3D -0.48 -6.03 -0.31 4.44e-9 Neuroticism; LUSC cis rs12971120 0.891 rs2278158 chr18:72178300 G/T cg26446133 chr18:72167187 CNDP2 -0.76 -9.13 -0.45 6.5e-18 Refractive error; LUSC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.76 0.39 1.04e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs911119 0.913 rs6036461 chr20:23576754 C/G cg16589663 chr20:23618590 CST3 0.62 7.44 0.38 8.78e-13 Chronic kidney disease; LUSC cis rs11971779 0.555 rs4728466 chr7:139096365 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs3845702 0.736 rs12465592 chr2:180862654 C/G cg01881094 chr2:180872142 CWC22 1.03 12.16 0.55 2.04e-28 Schizophrenia; LUSC cis rs703842 1.000 rs11172351 chr12:58213485 C/T cg12615879 chr12:58013172 SLC26A10 -0.32 -6.59 -0.34 1.67e-10 Multiple sclerosis; LUSC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg09323728 chr8:95962352 TP53INP1 -0.29 -5.72 -0.3 2.39e-8 Type 2 diabetes; LUSC cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg07606381 chr6:8435919 SLC35B3 0.72 12.3 0.56 6.11e-29 Motion sickness; LUSC cis rs477692 1.000 rs473073 chr10:131429646 G/T cg11019008 chr10:131425282 MGMT 0.41 6.02 0.31 4.72e-9 Response to temozolomide; LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.92 0.66 7.26e-43 Platelet count; LUSC cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg18904891 chr8:8559673 CLDN23 0.59 8.15 0.41 7.49e-15 Obesity-related traits; LUSC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg18306943 chr3:40428807 ENTPD3 0.39 6.09 0.32 3.09e-9 Renal cell carcinoma; LUSC cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg22681709 chr2:178499509 PDE11A 0.59 11.7 0.54 9.44e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg19824325 chr16:58548873 SETD6 0.94 9.15 0.45 5.74e-18 Schizophrenia; LUSC cis rs36093844 1.000 rs36093844 chr11:85576127 A/G cg25872744 chr11:85566296 CCDC83 0.5 7.66 0.39 2.06e-13 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs1670533 0.872 rs935969 chr4:1062588 A/G cg02018176 chr4:1364513 KIAA1530 0.43 5.76 0.3 1.92e-8 Recombination rate (females); LUSC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs35146811 0.696 rs1727124 chr7:99804104 T/G cg13334819 chr7:99746414 C7orf59 0.5 6.73 0.35 7.39e-11 Coronary artery disease; LUSC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg22709100 chr7:91322751 NA 0.44 6.28 0.32 1.06e-9 Breast cancer; LUSC cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg12573674 chr2:1569213 NA -0.52 -5.67 -0.3 3.07e-8 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg21171335 chr12:122356390 WDR66 0.64 9.57 0.46 2.4e-19 Mean corpuscular volume; LUSC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg13393036 chr8:95962371 TP53INP1 -0.31 -6.1 -0.32 2.92e-9 Type 2 diabetes; LUSC cis rs262150 0.502 rs73167295 chr7:158782949 T/A cg19418458 chr7:158789849 NA 0.51 6.6 0.34 1.63e-10 Facial morphology (factor 20); LUSC cis rs1670533 1.000 rs2045069 chr4:1052206 T/C cg02018176 chr4:1364513 KIAA1530 0.46 6.42 0.33 4.76e-10 Recombination rate (females); LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.56 0.78 4.18e-69 Prudent dietary pattern; LUSC cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.98 0.36 1.55e-11 Rheumatoid arthritis; LUSC cis rs4689388 0.890 rs4501291 chr4:6298582 C/T cg00701064 chr4:6280414 WFS1 0.61 15.07 0.64 1.62e-39 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9650657 0.740 rs10481451 chr8:10649328 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.25 -0.32 1.25e-9 Neuroticism; LUSC cis rs9354308 0.901 rs2814121 chr6:66566915 G/C cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs921968 0.541 rs4674310 chr2:219318078 T/C cg02176678 chr2:219576539 TTLL4 -0.74 -14.22 -0.61 3.41e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 6.15 0.32 2.21e-9 Tonsillectomy; LUSC cis rs2625529 0.824 rs12901886 chr15:72408069 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.59 -0.38 3.22e-13 Red blood cell count; LUSC cis rs7119038 0.818 rs10892286 chr11:118642085 A/C cg19308663 chr11:118741387 NA 0.36 6.17 0.32 1.96e-9 Sjögren's syndrome; LUSC cis rs6545883 1.000 rs6742276 chr2:61768745 G/A cg15711740 chr2:61764176 XPO1 -0.49 -7.84 -0.39 6.3e-14 Tuberculosis; LUSC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg20307385 chr11:47447363 PSMC3 -0.46 -5.96 -0.31 6.46e-9 Subjective well-being; LUSC cis rs713477 1.000 rs12888361 chr14:55906187 A/G cg04306507 chr14:55594613 LGALS3 -0.29 -5.65 -0.3 3.41e-8 Pediatric bone mineral content (femoral neck); LUSC trans rs2243480 0.711 rs1626926 chr7:65435792 C/T cg10756647 chr7:56101905 PSPH 0.85 8.34 0.42 2.04e-15 Diabetic kidney disease; LUSC cis rs7100689 0.646 rs7081889 chr10:82165427 C/A cg01528321 chr10:82214614 TSPAN14 0.84 12.88 0.58 4.21e-31 Post bronchodilator FEV1; LUSC cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg00409905 chr10:38381863 ZNF37A -0.34 -6.02 -0.31 4.7e-9 Extrinsic epigenetic age acceleration; LUSC cis rs1507153 0.847 rs9341741 chr6:79426838 G/A cg05283184 chr6:79620031 NA -0.42 -7.21 -0.37 3.86e-12 Sjögren's syndrome; LUSC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.6 0.34 1.6e-10 Tonsillectomy; LUSC cis rs5758511 0.689 rs17002947 chr22:42688532 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.51 -8.37 -0.42 1.64e-15 Birth weight; LUSC cis rs2806561 0.808 rs2235546 chr1:23409538 A/G cg19743168 chr1:23544995 NA 0.44 9.19 0.45 4.39e-18 Height; LUSC cis rs7267979 0.966 rs2424714 chr20:25418681 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg12463550 chr7:65579703 CRCP -0.47 -7.1 -0.36 7.36e-12 Aortic root size; LUSC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg06494592 chr3:125709126 NA -0.52 -5.91 -0.31 8.54e-9 Blood pressure (smoking interaction); LUSC cis rs2224391 0.628 rs11752747 chr6:5272671 A/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.2 -0.32 1.65e-9 Height; LUSC cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs7605827 0.897 rs10929371 chr2:15662299 A/G cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg08219700 chr8:58056026 NA 0.46 5.98 0.31 5.71e-9 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.745 rs2898260 chr8:10939490 G/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.13 -0.32 2.47e-9 Triglycerides; LUSC cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs2652834 1.000 rs7181141 chr15:63398552 A/G cg05507819 chr15:63340323 TPM1 0.67 8.15 0.41 7.6e-15 HDL cholesterol; LUSC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.85 0.47 2.83e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs34421088 0.506 rs2572426 chr8:11147123 C/T cg15556689 chr8:8085844 FLJ10661 0.45 6.74 0.35 6.91e-11 Neuroticism; LUSC cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg07777115 chr5:623756 CEP72 -0.44 -5.83 -0.3 1.3e-8 Obesity-related traits; LUSC cis rs79349575 0.745 rs170319 chr17:46991531 T/C cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg19717773 chr7:2847554 GNA12 -0.4 -7.13 -0.36 6.1e-12 Height; LUSC cis rs6138458 0.717 rs2179732 chr20:25000446 A/T cg26195577 chr20:24973756 C20orf3 0.8 12.45 0.56 1.73e-29 Blood protein levels; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg04630321 chr11:74204613 LIPT2 0.47 6.18 0.32 1.91e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs790123 1.000 rs790116 chr3:122380923 G/C cg00926285 chr3:122398533 PARP14 -0.38 -5.93 -0.31 7.62e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg17264618 chr3:40429014 ENTPD3 0.31 6.63 0.34 1.37e-10 Renal cell carcinoma; LUSC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.23 0.56 1.12e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg17985854 chr11:65770987 BANF1;EIF1AD -0.38 -6.47 -0.33 3.46e-10 Breast cancer; LUSC cis rs73206853 0.686 rs60439011 chr12:110909179 T/C cg12870014 chr12:110450643 ANKRD13A 0.69 7.51 0.38 5.56e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg09796270 chr17:17721594 SREBF1 0.42 7.51 0.38 5.43e-13 Total body bone mineral density; LUSC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg00033643 chr7:134001901 SLC35B4 0.47 7.42 0.38 9.63e-13 Mean platelet volume; LUSC cis rs597583 0.951 rs636530 chr11:117421858 C/T cg27161313 chr11:117392002 DSCAML1 0.4 7.22 0.37 3.52e-12 Putamen volume; LUSC cis rs7216064 0.953 rs62086044 chr17:65970837 G/T cg12091567 chr17:66097778 LOC651250 -0.68 -8.93 -0.44 2.92e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs28785552 0.554 rs10424921 chr19:53211087 T/C cg10871876 chr19:53194124 ZNF83 0.38 6.01 0.31 4.97e-9 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs2766692 0.956 rs35696661 chr14:100742355 G/C cg14866419 chr14:100704911 YY1 0.45 6.07 0.32 3.44e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7215564 0.730 rs34806161 chr17:78573839 T/C cg23238734 chr17:78661607 RPTOR 0.47 5.69 0.3 2.84e-8 Myopia (pathological); LUSC cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg09479241 chr17:27052676 TLCD1 -0.44 -6.05 -0.31 3.92e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.09e-11 Blood metabolite levels; LUSC cis rs28655083 1.000 rs1843455 chr16:77072343 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.38 -5.69 -0.3 2.72e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg20476274 chr7:133979776 SLC35B4 0.8 13.24 0.59 1.87e-32 Mean platelet volume; LUSC trans rs7613875 0.600 rs7061 chr3:50114515 C/T cg21659725 chr3:3221576 CRBN -0.56 -8.86 -0.44 5.01e-17 Body mass index; LUSC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg06238570 chr21:40685208 BRWD1 -0.59 -9.78 -0.47 4.87e-20 Cognitive function; LUSC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg17366294 chr4:99064904 C4orf37 0.54 8.83 0.43 6.14e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs3093024 0.904 rs3093019 chr6:167539655 C/G cg07741184 chr6:167504864 NA -0.41 -7.43 -0.38 9.43e-13 Rheumatoid arthritis; LUSC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs8114671 0.869 rs66535333 chr20:33656666 G/A cg07148914 chr20:33460835 GGT7 -0.46 -6.74 -0.35 7.17e-11 Height; LUSC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg06074448 chr4:187884817 NA -0.41 -6.89 -0.35 2.85e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs13082711 0.911 rs13089870 chr3:27447626 C/T cg02860705 chr3:27208620 NA 0.5 8.36 0.42 1.74e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs2832077 0.943 rs2832099 chr21:30173460 A/G cg14791747 chr16:20752902 THUMPD1 0.72 9.86 0.47 2.59e-20 Cognitive test performance; LUSC cis rs911119 0.913 rs3004145 chr20:23582876 C/G cg16589663 chr20:23618590 CST3 -0.59 -7.36 -0.37 1.4e-12 Chronic kidney disease; LUSC cis rs9815354 0.812 rs73071208 chr3:41978738 A/T cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs34779708 0.931 rs10508815 chr10:35332621 A/C cg04310649 chr10:35416472 CREM -0.41 -6.3 -0.33 9.65e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6598163 0.520 rs12813376 chr12:132302324 C/T cg22244940 chr12:132335942 MMP17 0.42 6.21 0.32 1.6e-9 Migraine; LUSC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC trans rs330071 0.686 rs4841139 chr8:9249210 C/T cg15556689 chr8:8085844 FLJ10661 0.53 8.13 0.41 8.44e-15 Acne (severe); LUSC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg11764359 chr7:65958608 NA -0.69 -11.1 -0.52 1.42e-24 Aortic root size; LUSC cis rs11098499 1.000 rs6837898 chr4:120179154 C/T cg24375607 chr4:120327624 NA 0.76 11.19 0.52 6.46e-25 Corneal astigmatism; LUSC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg24060327 chr5:131705240 SLC22A5 0.48 8.03 0.4 1.71e-14 Breast cancer; LUSC cis rs4901869 0.966 rs1820557 chr14:59334863 C/G cg02291164 chr14:59296302 NA 0.58 11.0 0.52 3.07e-24 Panic disorder; LUSC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg12963246 chr6:28129442 ZNF389 0.55 7.63 0.39 2.55e-13 Depression; LUSC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.37e-9 Life satisfaction; LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs1572438 0.811 rs6916731 chr6:880428 G/C cg13447295 chr6:887704 NA 0.4 6.29 0.33 1.01e-9 Aging; LUSC trans rs6502050 0.805 rs4789740 chr17:80119202 T/C cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg13319975 chr6:146136371 FBXO30 0.48 7.25 0.37 3.01e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4964805 0.580 rs1866292 chr12:104174192 C/T cg02344784 chr12:104178138 NT5DC3 0.43 6.82 0.35 4.37e-11 Attention deficit hyperactivity disorder; LUSC cis rs7674212 0.541 rs4699050 chr4:104114297 A/G cg16532752 chr4:104119610 CENPE -0.48 -6.82 -0.35 4.31e-11 Type 2 diabetes; LUSC cis rs9303401 0.659 rs35828828 chr17:56718205 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.61e-35 Cognitive test performance; LUSC cis rs9653442 0.593 rs6542920 chr2:100845088 A/G cg22139774 chr2:100720529 AFF3 -0.37 -6.05 -0.31 3.87e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg07167872 chr1:205819463 PM20D1 -0.39 -5.71 -0.3 2.55e-8 Parkinson's disease; LUSC cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg22681709 chr2:178499509 PDE11A -0.51 -9.17 -0.45 4.98e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg22963979 chr7:1858916 MAD1L1 -0.58 -8.97 -0.44 2.09e-17 Bipolar disorder and schizophrenia; LUSC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg20203395 chr5:56204925 C5orf35 -0.76 -10.12 -0.48 3.5e-21 Initial pursuit acceleration; LUSC cis rs1021993 0.597 rs10494921 chr1:209513501 A/G cg24446417 chr1:209558027 NA -0.35 -5.72 -0.3 2.43e-8 Gut microbiome composition (winter); LUSC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg20607287 chr7:12443886 VWDE -0.65 -6.47 -0.33 3.52e-10 Coronary artery disease; LUSC cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg01191920 chr7:158217561 PTPRN2 0.42 8.32 0.41 2.23e-15 Obesity-related traits; LUSC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg18876405 chr7:65276391 NA -0.54 -8.6 -0.43 3.19e-16 Aortic root size; LUSC cis rs10779751 1.000 rs7526649 chr1:11278163 C/T cg08854313 chr1:11322531 MTOR 0.86 14.51 0.62 2.46e-37 Body mass index; LUSC cis rs11039100 0.834 rs11039053 chr11:5812827 T/C cg13902645 chr11:5959945 NA -0.54 -5.97 -0.31 6.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs8060686 0.516 rs9938020 chr16:68251784 C/G cg09835421 chr16:68378352 PRMT7 -0.47 -5.78 -0.3 1.69e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg22920501 chr2:26401640 FAM59B -0.74 -10.78 -0.51 1.84e-23 Gut microbiome composition (summer); LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg07677032 chr17:61819896 STRADA 0.52 8.7 0.43 1.53e-16 Prudent dietary pattern; LUSC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg12257692 chr3:49977190 RBM6 0.24 6.54 0.34 2.35e-10 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg03806693 chr22:41940476 POLR3H -0.97 -13.97 -0.61 3.06e-35 Vitiligo; LUSC cis rs1904096 0.506 rs4693381 chr4:95206855 A/T cg11021082 chr4:95130006 SMARCAD1 0.43 7.99 0.4 2.17e-14 Type 2 diabetes; LUSC cis rs8014204 0.869 rs2070599 chr14:75361177 C/G cg06637938 chr14:75390232 RPS6KL1 -0.65 -10.77 -0.51 2.03e-23 Caffeine consumption; LUSC cis rs73206853 0.764 rs56123836 chr12:110999032 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 7.54 0.38 4.6e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs2926702 0.810 rs34726915 chr8:71055610 G/T cg16517358 chr11:46164796 NA 0.39 6.18 0.32 1.9e-9 Non-small cell lung cancer; LUSC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg05425664 chr17:57184151 TRIM37 -0.57 -8.8 -0.43 7.23e-17 Intelligence (multi-trait analysis); LUSC trans rs12043259 1.000 rs11240299 chr1:204847819 G/A cg23865240 chr7:27134109 HOXA1 -0.57 -6.01 -0.31 4.86e-9 Addiction; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg16606324 chr3:10149918 C3orf24 0.62 9.08 0.44 1e-17 Alzheimer's disease; LUSC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13732083 chr21:47605072 C21orf56 0.4 5.66 0.3 3.22e-8 Testicular germ cell tumor; LUSC cis rs1577917 0.958 rs2875456 chr6:86602284 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.88 -0.35 2.89e-11 Response to antipsychotic treatment; LUSC cis rs79976124 0.837 rs10944858 chr6:66646039 G/A cg07460842 chr6:66804631 NA 0.71 8.87 0.44 4.36e-17 Type 2 diabetes; LUSC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.31 0.49 7.78e-22 Homoarginine levels; LUSC cis rs1801251 1.000 rs283480 chr2:233648742 G/A cg25237894 chr2:233734115 C2orf82 0.36 6.16 0.32 2.14e-9 Coronary artery disease; LUSC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.12 0.66 1.19e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.66 0.65 8.05e-42 Platelet count; LUSC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.69 0.3 2.75e-8 Life satisfaction; LUSC trans rs11098499 0.675 rs11098534 chr4:120556772 T/G cg25214090 chr10:38739885 LOC399744 0.42 6.54 0.34 2.26e-10 Corneal astigmatism; LUSC cis rs4285028 0.580 rs2293611 chr3:121643163 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.48 -6.68 -0.34 9.9e-11 Multiple sclerosis; LUSC cis rs4588572 0.643 rs2012562 chr5:77768088 T/A cg11547950 chr5:77652471 NA -0.53 -7.61 -0.38 2.89e-13 Triglycerides; LUSC trans rs2262909 1.000 rs2017962 chr19:22208751 T/C cg05197062 chr11:11642011 GALNTL4 -0.51 -7.08 -0.36 8.34e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7264396 0.790 rs6579255 chr20:34219496 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.73 -0.47 7.04e-20 Total cholesterol levels; LUSC cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg03433033 chr1:76189801 ACADM -0.44 -6.59 -0.34 1.7e-10 Daytime sleep phenotypes; LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg22920501 chr2:26401640 FAM59B 0.83 12.02 0.55 6.49e-28 Gut microbiome composition (summer); LUSC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.64 0.43 2.32e-16 Height; LUSC cis rs6574644 1.000 rs7155930 chr14:81776026 G/C cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs9467711 0.606 rs9393707 chr6:26362486 T/C cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs8060686 0.641 rs28508024 chr16:68126606 T/C cg05110241 chr16:68378359 PRMT7 -0.51 -6.12 -0.32 2.69e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg08677398 chr8:58056175 NA 0.53 7.06 0.36 9.83e-12 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg08677398 chr8:58056175 NA 0.49 6.25 0.32 1.26e-9 Developmental language disorder (linguistic errors); LUSC cis rs748404 0.697 rs564946 chr15:43556272 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.78 0.3 1.75e-8 Lung cancer; LUSC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg12826209 chr6:26865740 GUSBL1 0.76 9.22 0.45 3.51e-18 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.05 -0.31 3.82e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11785400 1.000 rs11785400 chr8:143730456 C/T cg10596483 chr8:143751796 JRK 0.61 9.39 0.46 9.97e-19 Schizophrenia; LUSC cis rs2200578 0.841 rs112377545 chr2:99774823 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.51 5.87 0.31 1.03e-8 IgG glycosylation; LUSC cis rs4493873 0.731 rs7846412 chr8:92044528 A/G cg16814680 chr8:91681699 NA 0.41 5.67 0.3 3.17e-8 Migraine - clinic-based; LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg08200582 chr11:442649 ANO9 -0.51 -5.8 -0.3 1.51e-8 Body mass index; LUSC trans rs6582630 0.537 rs35336822 chr12:38346251 T/C cg06521331 chr12:34319734 NA -0.41 -6.35 -0.33 6.96e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs10911251 0.528 rs2333622 chr1:183075456 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.82 0.51 1.35e-23 Colorectal cancer; LUSC cis rs61931739 0.500 rs11053246 chr12:34516620 C/T cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.57e-10 Morning vs. evening chronotype; LUSC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg06112835 chr11:68658793 MRPL21 0.51 7.82 0.39 7.13e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg03433033 chr1:76189801 ACADM 0.61 8.59 0.43 3.38e-16 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7590720 0.840 rs705648 chr2:216933792 C/T cg12620499 chr2:216877984 MREG 0.85 12.46 0.56 1.55e-29 Alcohol dependence; LUSC cis rs6546537 1.000 rs4852892 chr2:69866769 T/A cg10773587 chr2:69614142 GFPT1 -0.53 -7.83 -0.39 6.43e-14 Serum thyroid-stimulating hormone levels; LUSC cis rs1371867 0.846 rs1660326 chr8:101290447 G/A cg06636551 chr8:101224915 SPAG1 -0.44 -8.01 -0.4 1.89e-14 Atrioventricular conduction; LUSC cis rs3859192 0.599 rs12451897 chr17:38179275 G/T cg17467752 chr17:38218738 THRA -0.5 -7.12 -0.36 6.64e-12 White blood cell count; LUSC cis rs76878669 0.561 rs12416747 chr11:66135614 A/G cg24851651 chr11:66362959 CCS -0.36 -5.68 -0.3 2.92e-8 Educational attainment (years of education); LUSC cis rs7937682 0.924 rs875257 chr11:111530453 A/G cg22437258 chr11:111473054 SIK2 0.5 6.89 0.35 2.78e-11 Primary sclerosing cholangitis; LUSC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg24324837 chr19:49891574 CCDC155 0.52 7.38 0.37 1.31e-12 Multiple sclerosis; LUSC cis rs9486719 1.000 rs2971603 chr6:97035418 C/T cg06623918 chr6:96969491 KIAA0776 -0.83 -12.1 -0.55 3.35e-28 Migraine;Coronary artery disease; LUSC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg20398880 chr6:41068722 NFYA;LOC221442 0.45 6.81 0.35 4.51e-11 Alzheimer's disease (late onset); LUSC cis rs1865760 0.865 rs9467647 chr6:25957642 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.91 0.35 2.42e-11 Height; LUSC cis rs926938 0.563 rs360586 chr1:115467489 A/G cg01522456 chr1:115632236 TSPAN2 -0.39 -5.81 -0.3 1.46e-8 Autism; LUSC cis rs9815354 0.716 rs73087368 chr3:41930379 A/G cg03022575 chr3:42003672 ULK4 0.82 8.55 0.42 4.49e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg08132940 chr7:1081526 C7orf50 -0.48 -5.95 -0.31 6.95e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 11.36 0.53 1.61e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.64 0.57 3.36e-30 Motion sickness; LUSC cis rs2742234 0.955 rs2075910 chr10:43614230 G/A cg02780029 chr10:43622663 RET -0.33 -6.12 -0.32 2.61e-9 Hirschsprung disease; LUSC cis rs6554196 0.508 rs3819393 chr4:55526615 C/T cg18836493 chr4:55524333 KIT -0.44 -7.51 -0.38 5.51e-13 Monocyte count; LUSC cis rs847577 0.748 rs940430 chr7:97716540 A/G cg24562669 chr7:97807699 LMTK2 0.43 7.32 0.37 1.86e-12 Breast cancer; LUSC cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg00310523 chr12:86230176 RASSF9 0.47 8.62 0.43 2.74e-16 Major depressive disorder; LUSC cis rs7666738 0.519 rs28539191 chr4:98821552 C/T cg05340658 chr4:99064831 C4orf37 0.63 9.23 0.45 3.25e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs6577655 0.501 rs7004326 chr8:135610915 G/T cg17885191 chr8:135476712 NA -0.43 -5.92 -0.31 7.98e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs56146971 0.670 rs12590074 chr14:91867390 T/G cg10511902 chr14:91842949 CCDC88C 0.44 5.8 0.3 1.54e-8 Alzheimer disease and age of onset; LUSC cis rs3733418 0.929 rs12510464 chr4:165919040 A/G cg06481168 chr4:165878055 C4orf39;TRIM61 -0.5 -5.69 -0.3 2.79e-8 Obesity-related traits; LUSC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.08e-10 Aortic root size; LUSC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg24110177 chr3:50126178 RBM5 -0.54 -8.79 -0.43 7.87e-17 Intelligence (multi-trait analysis); LUSC cis rs422249 0.615 rs174612 chr11:61628266 C/G cg06860612 chr11:61641270 FADS3 0.28 5.93 0.31 7.47e-9 Trans fatty acid levels; LUSC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.62 0.5 6.6e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs4332037 0.707 rs62435132 chr7:1891315 C/T cg11693508 chr17:37793320 STARD3 0.51 6.3 0.33 9.61e-10 Bipolar disorder; LUSC cis rs7582180 0.629 rs11685250 chr2:100955137 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.73 0.3 2.29e-8 Intelligence (multi-trait analysis); LUSC cis rs6120849 0.707 rs6120798 chr20:33610822 T/G cg24642439 chr20:33292090 TP53INP2 0.62 6.89 0.35 2.79e-11 Protein C levels; LUSC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg11062466 chr8:58055876 NA 0.77 8.62 0.43 2.76e-16 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg16606324 chr3:10149918 C3orf24 0.65 8.98 0.44 1.96e-17 Alzheimer's disease; LUSC trans rs877282 0.583 rs10904562 chr10:819058 T/C cg22713356 chr15:30763199 NA 0.74 9.48 0.46 4.8e-19 Uric acid levels; LUSC cis rs1801251 0.896 rs7573208 chr2:233696701 C/A cg25237894 chr2:233734115 C2orf82 -0.33 -6.11 -0.32 2.73e-9 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25613101 chr22:38577875 PLA2G6 0.44 6.64 0.34 1.3e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg04539111 chr16:67997858 SLC12A4 -0.46 -6.27 -0.32 1.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs12477438 0.765 rs13406288 chr2:99589585 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.11 -0.41 9.58e-15 Chronic sinus infection; LUSC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg16145915 chr7:1198662 ZFAND2A 0.45 8.34 0.42 2e-15 Longevity;Endometriosis; LUSC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg27432699 chr2:27873401 GPN1 0.55 8.3 0.41 2.68e-15 Total body bone mineral density; LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg22484793 chr3:52261325 TLR9 0.27 6.06 0.31 3.6e-9 Electroencephalogram traits; LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg08219700 chr8:58056026 NA 0.56 7.68 0.39 1.81e-13 Developmental language disorder (linguistic errors); LUSC cis rs617219 0.889 rs1717560 chr5:78438743 A/G cg24856658 chr5:78533917 JMY -0.31 -5.79 -0.3 1.62e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg16414030 chr3:133502952 NA 0.44 6.63 0.34 1.32e-10 Iron status biomarkers; LUSC cis rs4974559 0.790 rs6850727 chr4:1323273 G/C cg02980000 chr4:1222292 CTBP1 0.85 9.71 0.47 8.27e-20 Systolic blood pressure; LUSC cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg05738196 chr6:26577821 NA -0.55 -6.13 -0.32 2.54e-9 Intelligence (multi-trait analysis); LUSC cis rs892961 0.932 rs8066646 chr17:75414192 C/T cg05865280 chr17:75406074 SEPT9 0.46 9.67 0.47 1.13e-19 Airflow obstruction; LUSC cis rs4594175 0.926 rs9323206 chr14:51621800 C/T cg23942311 chr14:51606299 NA 0.33 6.22 0.32 1.46e-9 Cancer; LUSC cis rs7072216 0.770 rs3830020 chr10:100176615 C/G cg26618903 chr10:100175079 PYROXD2 0.32 6.28 0.32 1.06e-9 Metabolite levels; LUSC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg15468180 chr1:107600409 PRMT6 0.4 6.45 0.33 4e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg00745463 chr17:30367425 LRRC37B -0.68 -8.53 -0.42 5.02e-16 Hip circumference adjusted for BMI; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg18765753 chr7:1198926 ZFAND2A -0.49 -8.86 -0.44 4.73e-17 Longevity;Endometriosis; LUSC cis rs17253792 0.822 rs77182097 chr14:56136695 G/A cg01858014 chr14:56050164 KTN1 -0.77 -6.57 -0.34 1.95e-10 Putamen volume; LUSC cis rs4631830 0.863 rs4486572 chr10:51531805 A/G cg10326726 chr10:51549505 MSMB -0.36 -6.03 -0.31 4.23e-9 Prostate-specific antigen levels; LUSC trans rs2243480 1.000 rs709607 chr7:65449541 C/G cg10756647 chr7:56101905 PSPH -0.76 -6.95 -0.36 1.87e-11 Diabetic kidney disease; LUSC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg02269571 chr22:50332266 NA -0.66 -8.17 -0.41 6.29e-15 Schizophrenia; LUSC trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg20587970 chr11:113659929 NA -1.22 -16.28 -0.67 2.71e-44 Hip circumference adjusted for BMI; LUSC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.96 0.36 1.76e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7191439 0.674 rs4782429 chr16:88792097 A/G cg02389323 chr16:88786976 FAM38A 0.87 9.07 0.44 1.01e-17 Plateletcrit; LUSC cis rs7592578 0.679 rs62181019 chr2:191325414 A/G cg10560079 chr2:191398806 TMEM194B -0.65 -8.18 -0.41 5.91e-15 Diastolic blood pressure; LUSC cis rs57549656 0.799 rs741105 chr19:2711529 T/C cg06609049 chr19:2785107 THOP1 0.49 6.43 0.33 4.51e-10 Schizophrenia; LUSC cis rs11112613 0.609 rs7966960 chr12:106032152 G/A cg03607813 chr12:105948248 NA 0.62 7.85 0.39 5.7e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg20891558 chr2:74357851 NA 0.8 14.51 0.62 2.53e-37 Gestational age at birth (maternal effect); LUSC cis rs3087591 0.960 rs8067021 chr17:29555078 T/A cg24425628 chr17:29625626 OMG;NF1 -0.55 -8.0 -0.4 2.06e-14 Hip circumference; LUSC trans rs61931739 0.534 rs11052974 chr12:34029877 T/G cg13010199 chr12:38710504 ALG10B 0.55 8.37 0.42 1.63e-15 Morning vs. evening chronotype; LUSC cis rs3820068 0.705 rs11577225 chr1:15864242 T/C cg17385448 chr1:15911702 AGMAT 0.38 5.73 0.3 2.22e-8 Systolic blood pressure; LUSC cis rs12530845 1.000 rs12531468 chr7:135336264 T/G cg23117316 chr7:135346802 PL-5283 -0.55 -9.3 -0.45 1.88e-18 Red blood cell traits; LUSC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18404041 chr3:52824283 ITIH1 -0.51 -9.73 -0.47 7.44e-20 Bipolar disorder; LUSC cis rs2933343 0.679 rs789229 chr3:128602526 C/T cg11901034 chr3:128598214 ACAD9 -0.4 -6.21 -0.32 1.57e-9 IgG glycosylation; LUSC cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.81 0.51 1.44e-23 Bladder cancer; LUSC cis rs300703 0.719 rs385272 chr2:206704 A/G cg21211680 chr2:198530 NA -0.67 -7.87 -0.4 4.97e-14 Blood protein levels; LUSC cis rs9427116 0.502 rs9426829 chr1:154592201 T/C cg17218026 chr1:154582156 ADAR 0.56 10.0 0.48 9.16e-21 Blood protein levels; LUSC cis rs6964587 0.933 rs13230837 chr7:91779017 A/G cg17063962 chr7:91808500 NA 0.58 8.91 0.44 3.39e-17 Breast cancer; LUSC cis rs9300255 0.506 rs61388686 chr12:123810873 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.53 -0.34 2.44e-10 Neutrophil percentage of white cells; LUSC cis rs7953249 0.618 rs7954039 chr12:121398654 A/C cg25281562 chr12:121454272 C12orf43 -0.43 -5.65 -0.3 3.48e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg10645314 chr2:3704589 ALLC 0.52 9.04 0.44 1.31e-17 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9300255 0.544 rs1716175 chr12:123658388 A/T cg13010344 chr12:123464640 ARL6IP4 -0.47 -6.34 -0.33 7.45e-10 Neutrophil percentage of white cells; LUSC cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg05738196 chr6:26577821 NA -0.82 -15.12 -0.64 1.06e-39 Intelligence (multi-trait analysis); LUSC cis rs4899260 0.779 rs4899261 chr14:69283375 C/T cg03189333 chr14:69283534 NA -0.48 -5.99 -0.31 5.58e-9 Celiac disease; LUSC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7216064 1.000 rs8071463 chr17:65938655 C/T cg12091567 chr17:66097778 LOC651250 0.74 9.54 0.46 3.19e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7589342 0.894 rs7557976 chr2:106435061 C/A cg16077055 chr2:106428750 NCK2 0.38 7.26 0.37 2.75e-12 Addiction; LUSC cis rs9443645 0.545 rs10755377 chr6:79637925 T/C cg23262351 chr6:79576851 IRAK1BP1 -0.39 -5.92 -0.31 7.88e-9 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.752 rs1534030 chr3:134330083 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs7647973 0.593 rs1799844 chr3:49847642 G/A cg21659725 chr3:3221576 CRBN 0.69 8.16 0.41 6.93e-15 Menarche (age at onset); LUSC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg22875332 chr1:76189707 ACADM -0.76 -10.09 -0.48 4.42e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7824557 0.564 rs11781637 chr8:11214972 C/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.51 -0.34 2.69e-10 Retinal vascular caliber; LUSC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg20573242 chr4:122745356 CCNA2 0.63 9.9 0.48 2e-20 Type 2 diabetes; LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg25036284 chr2:26402008 FAM59B 0.78 11.06 0.52 1.94e-24 Gut microbiome composition (summer); LUSC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.7 0.54 1.01e-26 Hip circumference adjusted for BMI; LUSC cis rs10465746 0.967 rs5028806 chr1:84329295 G/A cg10977910 chr1:84465055 TTLL7 0.44 6.39 0.33 5.72e-10 Obesity-related traits; LUSC trans rs1908814 0.516 rs13281077 chr8:11794814 C/T cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.76e-9 Neuroticism; LUSC cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg12011299 chr4:100065546 ADH4 0.7 10.49 0.5 1.92e-22 Smoking initiation; LUSC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg07703079 chr11:430292 ANO9 0.64 6.48 0.33 3.23e-10 Body mass index; LUSC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg06238570 chr21:40685208 BRWD1 0.5 7.69 0.39 1.66e-13 Cognitive function; LUSC cis rs17155006 0.691 rs403731 chr7:107744217 C/T cg05962710 chr7:107745446 LAMB4 0.34 6.15 0.32 2.26e-9 Pneumococcal bacteremia; LUSC trans rs931812 1.000 rs4734495 chr8:101917817 C/A cg20993868 chr7:22813445 NA 0.59 10.86 0.51 9.58e-24 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs2731664 0.819 rs449351 chr5:176872591 T/C cg23176889 chr5:176863531 GRK6 -0.69 -14.17 -0.61 5.16e-36 Intelligence (multi-trait analysis); LUSC cis rs7607369 0.559 rs4674340 chr2:219659799 A/G cg02176678 chr2:219576539 TTLL4 -0.53 -9.51 -0.46 4.03e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs3733585 0.605 rs56178126 chr4:10123581 C/T cg26043149 chr18:55253948 FECH -0.51 -7.32 -0.37 1.87e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7769051 1.000 rs12203977 chr6:133122760 A/G cg07930552 chr6:133119739 C6orf192 0.79 10.32 0.49 7.22e-22 Type 2 diabetes nephropathy; LUSC cis rs679087 0.612 rs7970465 chr12:29905251 C/T cg14258853 chr12:29935411 TMTC1 -0.99 -14.83 -0.63 1.43e-38 Schizophrenia; LUSC cis rs8056893 0.513 rs3785111 chr16:68309971 A/T cg02226672 chr16:68398533 SMPD3 0.3 5.83 0.3 1.31e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC trans rs10090774 0.710 rs13264524 chr8:141654658 A/G cg02991888 chr19:54260014 MIR1283-2;MIR516A1 0.29 5.96 0.31 6.4e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs10744422 0.800 rs11059724 chr12:123235978 T/G cg25930673 chr12:123319894 HIP1R 0.58 5.98 0.31 5.68e-9 Schizophrenia; LUSC cis rs2274273 0.713 rs56725788 chr14:55540101 A/G cg04306507 chr14:55594613 LGALS3 0.5 10.72 0.51 3.17e-23 Protein biomarker; LUSC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.12 0.52 1.15e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg11764359 chr7:65958608 NA 0.69 10.56 0.5 1.14e-22 Aortic root size; LUSC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg22823121 chr1:150693482 HORMAD1 -0.45 -6.63 -0.34 1.36e-10 Tonsillectomy; LUSC cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg07741184 chr6:167504864 NA 0.43 7.61 0.38 2.8e-13 Primary biliary cholangitis; LUSC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg09913183 chr17:42254507 C17orf65;ASB16 0.61 9.48 0.46 4.79e-19 Total body bone mineral density; LUSC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg06671706 chr8:8559999 CLDN23 0.5 6.86 0.35 3.37e-11 Obesity-related traits; LUSC cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg18132916 chr6:79620363 NA -0.38 -5.74 -0.3 2.09e-8 Intelligence (multi-trait analysis); LUSC cis rs877282 0.853 rs11596346 chr10:756673 A/T cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs9914988 0.943 rs9303621 chr17:27161138 A/G cg09479241 chr17:27052676 TLCD1 0.44 6.17 0.32 1.96e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9311676 0.656 rs7642652 chr3:58373667 C/T cg26110898 chr3:58419937 PDHB 0.42 6.75 0.35 6.62e-11 Systemic lupus erythematosus; LUSC cis rs239198 0.578 rs13193416 chr6:101299602 A/T cg09795085 chr6:101329169 ASCC3 0.45 6.36 0.33 6.54e-10 Menarche (age at onset); LUSC cis rs7524258 0.868 rs4908607 chr1:7269323 A/G cg07173049 chr1:7289937 CAMTA1 0.34 7.04 0.36 1.07e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs500891 0.645 rs6454330 chr6:84175552 G/T cg08257003 chr6:84140564 ME1 -0.31 -7.01 -0.36 1.36e-11 Platelet-derived growth factor BB levels; LUSC cis rs614226 0.935 rs7956998 chr12:120994932 G/A cg01236616 chr12:121019343 POP5 1.32 22.06 0.77 3.52e-67 Type 1 diabetes nephropathy; LUSC cis rs4889855 0.578 rs7216808 chr17:78484187 A/G cg00066239 chr17:78472159 NA -0.43 -7.23 -0.37 3.4e-12 Fractional excretion of uric acid; LUSC cis rs6464929 1.000 rs1551926 chr7:148719583 C/T cg23583168 chr7:148888333 NA 0.46 5.99 0.31 5.56e-9 Pediatric bone mineral content (hip); LUSC cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg25173405 chr17:45401733 C17orf57 -0.37 -5.92 -0.31 8e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1448094 0.690 rs7132879 chr12:86289864 A/G cg02569458 chr12:86230093 RASSF9 0.53 8.59 0.43 3.31e-16 Major depressive disorder; LUSC cis rs9329221 0.597 rs17751178 chr8:10116730 A/G cg27411982 chr8:10470053 RP1L1 0.41 6.1 0.32 2.91e-9 Neuroticism; LUSC trans rs61931739 0.817 rs592857 chr12:34197673 T/G cg26384229 chr12:38710491 ALG10B 0.55 8.85 0.44 5.15e-17 Morning vs. evening chronotype; LUSC cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs929354 0.651 rs6951298 chr7:156949149 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC cis rs11758351 1.000 rs11754744 chr6:26202605 G/A cg01420254 chr6:26195488 NA 0.72 7.48 0.38 6.52e-13 Gout;Renal underexcretion gout; LUSC cis rs17155006 0.664 rs448833 chr7:107739181 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.3 -0.33 9.63e-10 Pneumococcal bacteremia; LUSC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10883723 0.962 rs1056738 chr10:104236481 G/A cg05855489 chr10:104503620 C10orf26 -0.69 -9.87 -0.48 2.54e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9888739 1.000 rs7190018 chr16:31301478 G/A cg15817542 chr16:31343056 ITGAM -0.5 -6.02 -0.31 4.65e-9 Systemic lupus erythematosus; LUSC cis rs66887589 0.967 rs13104219 chr4:120438174 G/T cg09307838 chr4:120376055 NA 0.48 7.19 0.37 4.23e-12 Diastolic blood pressure; LUSC trans rs853679 0.607 rs13190888 chr6:28285985 G/A cg06606381 chr12:133084897 FBRSL1 -0.92 -8.75 -0.43 1.06e-16 Depression; LUSC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg14668632 chr7:2872130 GNA12 -0.48 -7.11 -0.36 7.01e-12 Height; LUSC cis rs7267979 1.000 rs4815409 chr20:25346697 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg26516362 chr5:178986906 RUFY1 0.48 8.27 0.41 3.2e-15 Lung cancer; LUSC trans rs561341 0.740 rs11080174 chr17:30208521 C/A cg20587970 chr11:113659929 NA 0.78 9.92 0.48 1.72e-20 Hip circumference adjusted for BMI; LUSC cis rs10791097 0.967 rs10894268 chr11:130717153 C/T cg12179176 chr11:130786555 SNX19 0.65 9.91 0.48 1.81e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.02 0.44 1.53e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs10886558 0.674 rs883448 chr10:121772123 G/C cg02041677 chr10:121771263 NA -0.33 -6.15 -0.32 2.19e-9 Shingles; LUSC cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg16346588 chr10:242978 ZMYND11 0.4 5.67 0.3 3.15e-8 Psychosis in Alzheimer's disease; LUSC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC cis rs2050392 0.737 rs7898978 chr10:30699800 T/C cg25182066 chr10:30743637 MAP3K8 0.43 6.08 0.32 3.3e-9 Inflammatory bowel disease; LUSC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg00149659 chr3:10157352 C3orf10 0.62 8.72 0.43 1.36e-16 Alzheimer's disease; LUSC trans rs9329221 0.537 rs6983332 chr8:9977918 A/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.48 -0.38 6.76e-13 Neuroticism; LUSC trans rs7746199 0.668 rs34864796 chr6:27459923 G/A cg06606381 chr12:133084897 FBRSL1 -0.81 -7.93 -0.4 3.24e-14 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs6736093 0.796 rs13024271 chr2:112814326 G/A cg12686935 chr2:112915763 FBLN7 -0.4 -6.37 -0.33 6.41e-10 Coronary artery disease; LUSC trans rs67133203 0.851 rs12366756 chr12:51403206 A/G cg17484237 chr5:156536107 HAVCR2 0.44 6.01 0.31 4.95e-9 Urinary tract infection frequency; LUSC cis rs17407555 0.738 rs56402960 chr4:10086473 T/A cg11266682 chr4:10021025 SLC2A9 -0.45 -5.88 -0.31 1.02e-8 Schizophrenia (age at onset); LUSC cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg15556689 chr8:8085844 FLJ10661 -0.63 -9.44 -0.46 6.42e-19 Mood instability; LUSC cis rs1865760 0.929 rs1816546 chr6:25938252 C/T cg16482183 chr6:26056742 HIST1H1C 0.47 6.66 0.34 1.16e-10 Height; LUSC cis rs77972916 0.611 rs61552842 chr2:43584036 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.49 -6.21 -0.32 1.61e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs79976124 0.797 rs74995761 chr6:66640216 G/A cg07460842 chr6:66804631 NA 0.72 9.05 0.44 1.2e-17 Type 2 diabetes; LUSC cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg26384229 chr12:38710491 ALG10B -0.83 -15.55 -0.65 2.11e-41 Heart rate; LUSC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg13072238 chr3:49761600 GMPPB -0.69 -8.14 -0.41 8.15e-15 Menarche (age at onset); LUSC cis rs13089785 1.000 rs34159794 chr3:123645893 A/G cg01860459 chr3:123419554 MYLK 0.35 5.85 0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC cis rs7523273 0.606 rs2796262 chr1:207915180 G/A cg22525895 chr1:207977042 MIR29B2 0.4 6.51 0.34 2.76e-10 Schizophrenia; LUSC cis rs10754283 0.901 rs10922683 chr1:90116068 G/A cg21401794 chr1:90099060 LRRC8C 0.63 9.02 0.44 1.46e-17 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg20643362 chr19:30206369 C19orf12 -0.53 -6.44 -0.33 4.1e-10 Cognitive function;Information processing speed; LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg26314531 chr2:26401878 FAM59B -0.71 -9.69 -0.47 1.03e-19 Gut microbiome composition (summer); LUSC cis rs1153858 0.723 rs1719238 chr15:45594766 C/T cg14582100 chr15:45693742 SPATA5L1 -0.54 -9.31 -0.45 1.77e-18 Homoarginine levels; LUSC cis rs8062405 0.964 rs7187333 chr16:28865916 G/A cg05966235 chr16:28915196 ATP2A1 0.34 5.96 0.31 6.43e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs611744 0.647 rs4735053 chr8:109260776 A/G cg18478394 chr8:109455254 TTC35 0.41 6.41 0.33 5.06e-10 Dupuytren's disease; LUSC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg22508957 chr16:3507546 NAT15 0.67 11.19 0.52 6.72e-25 Tuberculosis; LUSC cis rs367615 0.731 rs58241713 chr5:108853664 G/A cg17395555 chr5:108820864 NA 0.57 10.15 0.49 2.81e-21 Colorectal cancer (SNP x SNP interaction); LUSC cis rs2580764 0.573 rs13387751 chr2:55227375 C/G cg09592903 chr2:55203963 RTN4 -0.49 -10.11 -0.48 4e-21 Mean platelet volume; LUSC cis rs13385 0.769 rs7703595 chr5:139611190 A/C cg26211634 chr5:139558579 C5orf32 0.45 7.38 0.37 1.23e-12 Atrial fibrillation; LUSC cis rs7582180 0.627 rs4149517 chr2:101014247 C/A cg08017756 chr2:100939284 LONRF2 -0.43 -8.13 -0.41 8.43e-15 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg22437258 chr11:111473054 SIK2 0.54 7.58 0.38 3.45e-13 Primary sclerosing cholangitis; LUSC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg06074448 chr4:187884817 NA -0.4 -6.53 -0.34 2.45e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs2580764 0.566 rs2968794 chr2:55290651 C/G cg20993754 chr2:55226987 RTN4 0.36 6.14 0.32 2.29e-9 Mean platelet volume; LUSC cis rs3126085 0.935 rs12729662 chr1:152185750 G/A cg03465714 chr1:152285911 FLG 0.42 5.82 0.3 1.36e-8 Atopic dermatitis; LUSC cis rs6964587 1.000 rs2299232 chr7:91626699 A/C cg17063962 chr7:91808500 NA 0.53 8.01 0.4 1.91e-14 Breast cancer; LUSC cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg06784218 chr1:46089804 CCDC17 0.46 9.13 0.45 6.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4908769 0.660 rs13596 chr1:8421203 T/C cg00546117 chr1:8445545 RERE 0.29 5.68 0.3 2.89e-8 Allergy; LUSC cis rs11645898 0.748 rs56387295 chr16:72055336 C/A cg14768367 chr16:72042858 DHODH -0.78 -8.38 -0.42 1.54e-15 Blood protein levels; LUSC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.82 -12.31 -0.56 5.67e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.47 -8.12 -0.41 8.96e-15 Lymphocyte counts; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg02353165 chr6:42928485 GNMT 0.74 13.36 0.59 6.47e-33 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs3942852 0.955 rs7117386 chr11:48125371 G/A cg15704280 chr7:45808275 SEPT13 -0.55 -6.36 -0.33 6.83e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg11742103 chr11:62369870 EML3;MTA2 0.55 8.98 0.44 1.97e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7216064 1.000 rs7224923 chr17:65842265 T/G cg12091567 chr17:66097778 LOC651250 -0.75 -9.35 -0.46 1.27e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2742417 0.609 rs11709306 chr3:45773732 G/A cg10512202 chr3:45649293 LIMD1 0.36 5.94 0.31 7.3e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg13939156 chr17:80058883 NA -0.34 -6.68 -0.34 9.94e-11 Life satisfaction; LUSC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.75 0.3 2.03e-8 Tonsillectomy; LUSC cis rs732765 0.648 rs8019391 chr14:75409682 T/C cg06637938 chr14:75390232 RPS6KL1 0.55 6.72 0.35 7.72e-11 Non-small cell lung cancer; LUSC cis rs6964587 0.633 rs13231620 chr7:91507859 G/A cg17063962 chr7:91808500 NA -0.49 -7.42 -0.38 9.77e-13 Breast cancer; LUSC cis rs5758511 0.514 rs5751222 chr22:42517922 T/A cg00645731 chr22:42541494 CYP2D7P1 0.6 10.05 0.48 6.31e-21 Birth weight; LUSC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg01448562 chr3:133502909 NA -0.77 -12.96 -0.58 2.08e-31 Iron status biomarkers; LUSC cis rs72772090 0.539 rs55996659 chr5:96114150 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -7.05 -0.36 1.05e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg07217954 chr7:1067459 C7orf50 0.53 5.71 0.3 2.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7524258 0.835 rs7521425 chr1:7306543 C/T cg07173049 chr1:7289937 CAMTA1 0.32 6.53 0.34 2.38e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7172677 1.000 rs4886659 chr15:75414760 A/G cg14664628 chr15:75095509 CSK -0.45 -5.76 -0.3 1.9e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs694739 0.726 rs17857342 chr11:64138905 T/G cg23796481 chr11:64053134 BAD;GPR137 0.51 7.98 0.4 2.37e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.3 0.49 8.56e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg18404041 chr3:52824283 ITIH1 -0.6 -11.64 -0.54 1.58e-26 Bipolar disorder; LUSC cis rs11155671 0.530 rs2342767 chr6:150209717 C/G cg09699651 chr6:150184138 LRP11 0.45 7.17 0.37 4.98e-12 Testicular germ cell tumor; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg01802117 chr1:53393560 SCP2 0.39 6.49 0.33 3.15e-10 Monocyte count; LUSC cis rs12421382 0.614 rs12575538 chr11:109390966 C/A cg27471124 chr11:109292789 C11orf87 0.37 6.74 0.35 6.83e-11 Schizophrenia; LUSC cis rs7107174 1.000 rs2511170 chr11:77980582 A/G cg02023728 chr11:77925099 USP35 0.41 5.89 0.31 9.37e-9 Testicular germ cell tumor; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg07677032 chr17:61819896 STRADA 0.53 8.99 0.44 1.89e-17 Prudent dietary pattern; LUSC cis rs11098499 0.954 rs59866101 chr4:120296591 T/G cg09307838 chr4:120376055 NA 0.78 11.3 0.53 2.71e-25 Corneal astigmatism; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.04 -0.31 4.09e-9 Bipolar disorder; LUSC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 10.09 0.48 4.6e-21 Bipolar disorder; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs11105298 0.891 rs4842661 chr12:89930399 A/G cg00757033 chr12:89920650 WDR51B 0.58 9.91 0.48 1.8e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7215564 0.908 rs2873060 chr17:78663497 A/C cg23238734 chr17:78661607 RPTOR 0.47 6.1 0.32 2.98e-9 Myopia (pathological); LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg12564285 chr5:131593104 PDLIM4 0.56 10.79 0.51 1.81e-23 Acylcarnitine levels; LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg15790184 chr11:494944 RNH1 0.42 6.42 0.33 4.69e-10 Systemic lupus erythematosus; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02991799 chr19:35168510 ZNF302 -0.41 -5.99 -0.31 5.36e-9 Electrocardiographic conduction measures; LUSC trans rs9929218 0.954 rs17715799 chr16:68830511 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -10.58 -0.5 9.67e-23 Colorectal cancer; LUSC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg12463550 chr7:65579703 CRCP -0.51 -7.33 -0.37 1.74e-12 Aortic root size; LUSC trans rs853679 0.517 rs6932109 chr6:28078303 A/G cg06606381 chr12:133084897 FBRSL1 0.44 5.96 0.31 6.56e-9 Depression; LUSC cis rs2354432 0.607 rs11579626 chr1:146741960 A/C cg25205988 chr1:146714368 CHD1L -1.0 -9.35 -0.46 1.26e-18 Mitochondrial DNA levels; LUSC trans rs1493916 0.870 rs7239173 chr18:31395534 A/T cg27147174 chr7:100797783 AP1S1 -0.64 -10.29 -0.49 9.09e-22 Life satisfaction; LUSC cis rs4660261 0.526 rs2485997 chr1:44345841 G/C cg12908607 chr1:44402522 ARTN -0.45 -7.05 -0.36 1e-11 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03105603 chr7:39772936 LOC349114 -0.49 -5.97 -0.31 5.91e-9 Bipolar disorder and schizophrenia; LUSC cis rs7588746 0.621 rs4672726 chr2:201149413 C/T cg23649088 chr2:200775458 C2orf69 -0.41 -5.72 -0.3 2.32e-8 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25356086 chr21:33764900 C21orf119;URB1 0.46 6.46 0.33 3.62e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg20933634 chr6:27740509 NA 0.41 5.72 0.3 2.43e-8 Parkinson's disease; LUSC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11644478 chr21:40555479 PSMG1 0.87 14.82 0.63 1.61e-38 Cognitive function; LUSC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 1.94e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12681288 0.676 rs2600514 chr8:994175 G/A cg15309053 chr8:964076 NA 0.37 7.52 0.38 5.18e-13 Schizophrenia; LUSC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg23711669 chr6:146136114 FBXO30 0.9 17.22 0.69 5.31e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs1706867 0.633 rs823537 chr2:2493938 A/G cg16599136 chr19:49561594 NA -0.32 -6.05 -0.31 3.79e-9 Facial morphology (factor 14, intercanthal width); LUSC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -5.97 -0.31 5.98e-9 Major depressive disorder; LUSC cis rs9388451 0.874 rs13209968 chr6:126089285 G/C cg10911889 chr6:126070802 HEY2 0.43 6.55 0.34 2.11e-10 Brugada syndrome; LUSC cis rs905938 0.559 rs74520550 chr1:155006450 C/A cg16256492 chr1:154989843 ZBTB7B 0.63 7.23 0.37 3.24e-12 Waist-to-hip ratio adjusted for body mass index;Birth length;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs3812049 0.826 rs17764730 chr5:127357526 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 8.84 0.44 5.41e-17 Lymphocyte counts;Red cell distribution width; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg06877462 chr1:205807181 PM20D1 0.56 10.34 0.49 6.48e-22 Menarche (age at onset); LUSC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg05585544 chr11:47624801 NA 0.4 6.98 0.36 1.55e-11 Subjective well-being; LUSC cis rs921968 0.643 rs4674319 chr2:219510320 C/T cg02176678 chr2:219576539 TTLL4 0.6 10.75 0.51 2.34e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs12545109 0.800 rs1467124 chr8:57418862 T/G cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC trans rs61931739 0.534 rs1844526 chr12:34102780 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg00149659 chr3:10157352 C3orf10 0.89 11.83 0.54 3.19e-27 Alzheimer's disease; LUSC cis rs1957429 0.614 rs62621845 chr14:65403525 T/A cg23373153 chr14:65346875 NA -0.98 -7.73 -0.39 1.3e-13 Pediatric areal bone mineral density (radius); LUSC cis rs16949788 1.000 rs12323975 chr15:66674634 T/C cg08120210 chr15:66682733 MAP2K1 -0.58 -5.82 -0.3 1.41e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3820928 0.605 rs2228555 chr2:227872995 C/T cg11843606 chr2:227700838 RHBDD1 0.61 9.66 0.47 1.27e-19 Pulmonary function; LUSC cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg21770322 chr7:97807741 LMTK2 0.44 7.53 0.38 4.88e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs295140 1.000 rs10931897 chr2:201162520 T/C cg04283868 chr2:201171347 SPATS2L 0.43 6.57 0.34 1.95e-10 QT interval; LUSC trans rs804280 1.000 rs804281 chr8:11611865 A/G cg15556689 chr8:8085844 FLJ10661 0.61 8.83 0.44 5.85e-17 Myopia (pathological); LUSC cis rs7091068 0.616 rs4322326 chr10:95483382 A/T cg20715218 chr10:95462985 C10orf4 0.62 7.06 0.36 9.91e-12 Urinary tract infection frequency; LUSC cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg04117972 chr1:227635322 NA 0.58 6.73 0.35 7.61e-11 Major depressive disorder; LUSC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.18 0.55 1.67e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg13319975 chr6:146136371 FBXO30 -0.53 -7.94 -0.4 3.06e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs10791323 0.572 rs10791334 chr11:133735810 A/C cg00579200 chr11:133705235 NA -0.4 -5.86 -0.31 1.09e-8 Childhood ear infection; LUSC cis rs6163 0.508 rs12776506 chr10:104532828 A/G cg04362960 chr10:104952993 NT5C2 0.53 7.58 0.38 3.34e-13 Waist circumference;Hip circumference; LUSC cis rs983392 0.679 rs1026253 chr11:60030556 G/A cg02771260 chr11:59836817 MS4A3 0.37 5.99 0.31 5.34e-9 Alzheimer's disease (late onset); LUSC cis rs1413885 0.549 rs1334877 chr1:65846406 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.47 6.77 0.35 5.79e-11 Anticoagulant levels; LUSC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg05785598 chr3:49045655 WDR6 0.33 5.9 0.31 8.92e-9 Parkinson's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01485948 chr17:2296549 MNT -0.49 -6.25 -0.32 1.25e-9 Bipolar disorder and schizophrenia; LUSC cis rs9929218 0.551 rs2296409 chr16:68713730 G/A cg01251360 chr16:68772225 CDH1 -0.26 -6.29 -0.33 1e-9 Colorectal cancer; LUSC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg04398451 chr17:18023971 MYO15A -0.48 -7.72 -0.39 1.34e-13 Total body bone mineral density; LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC cis rs2346177 0.816 rs74179078 chr2:46654651 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.58 -9.3 -0.45 1.94e-18 HDL cholesterol; LUSC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg14552801 chr7:65878734 NA -0.45 -6.52 -0.34 2.6e-10 Aortic root size; LUSC trans rs979233 0.502 rs905098 chr5:42110159 T/C cg07010552 chr17:7358735 CHRNB1 -0.41 -6.03 -0.31 4.29e-9 Systemic lupus erythematosus; LUSC cis rs7189233 0.531 rs9941254 chr16:53487218 C/T cg09728985 chr16:53543985 NA -0.31 -5.81 -0.3 1.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7786808 0.579 rs4045391 chr7:158181826 T/C cg01191920 chr7:158217561 PTPRN2 -0.5 -10.31 -0.49 7.8e-22 Obesity-related traits; LUSC cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg15485101 chr11:133734466 NA 0.43 7.72 0.39 1.4e-13 Childhood ear infection; LUSC trans rs9329221 0.736 rs11250002 chr8:10257041 T/G cg06636001 chr8:8085503 FLJ10661 0.52 7.18 0.37 4.49e-12 Neuroticism; LUSC cis rs11931598 1.000 rs11931598 chr4:7047102 A/G cg02503808 chr4:7069936 GRPEL1 0.41 5.76 0.3 1.9e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs7681440 0.904 rs28734152 chr4:90767359 C/T cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs4654899 0.772 rs12404954 chr1:21074727 A/G cg01072550 chr1:21505969 NA -0.43 -6.33 -0.33 7.97e-10 Superior frontal gyrus grey matter volume; LUSC cis rs7615316 0.779 rs10935461 chr3:142079379 A/G cg16271453 chr3:142027066 XRN1 -0.4 -6.96 -0.36 1.85e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7917772 0.582 rs6584512 chr10:104329685 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7666738 0.546 rs28444809 chr4:98916934 C/T cg17366294 chr4:99064904 C4orf37 0.55 8.84 0.44 5.57e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.657 rs71614442 chr4:120379346 C/T cg24375607 chr4:120327624 NA 0.78 11.63 0.54 1.74e-26 Corneal astigmatism; LUSC cis rs2346177 0.542 rs718849 chr2:46698116 G/A cg02822958 chr2:46747628 ATP6V1E2 0.47 8.27 0.41 3.14e-15 HDL cholesterol; LUSC cis rs4595586 0.545 rs12812750 chr12:39363258 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.07 0.36 9.17e-12 Morning vs. evening chronotype; LUSC cis rs12989701 0.935 rs12994284 chr2:127874020 T/C cg08168897 chr2:127865431 BIN1 0.71 9.36 0.46 1.2e-18 Alzheimer's disease (late onset); LUSC cis rs9902453 0.836 rs62070337 chr17:28466257 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.19 0.41 5.57e-15 Coffee consumption (cups per day); LUSC cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC trans rs11700980 1.000 rs2832053 chr21:30130977 G/A cg05609335 chr17:75789393 NA 0.4 6.01 0.31 4.82e-9 QRS complex (12-leadsum); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16202598 chr3:179322434 NDUFB5;MRPL47 -0.42 -6.08 -0.32 3.22e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg07936489 chr17:37558343 FBXL20 0.72 10.11 0.48 3.92e-21 Glomerular filtration rate (creatinine); LUSC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg05623727 chr3:50126028 RBM5 0.32 6.04 0.31 4.04e-9 Intelligence (multi-trait analysis); LUSC cis rs6424115 1.000 rs7521961 chr1:24157634 C/T cg10978503 chr1:24200527 CNR2 -0.51 -11.96 -0.55 1.15e-27 Immature fraction of reticulocytes; LUSC cis rs7927592 0.913 rs3740631 chr11:68341722 T/G cg01657329 chr11:68192670 LRP5 -0.4 -5.73 -0.3 2.24e-8 Total body bone mineral density; LUSC cis rs11758351 0.660 rs113208674 chr6:26210465 C/G cg23601095 chr6:26197514 HIST1H3D 0.7 7.47 0.38 7.17e-13 Gout;Renal underexcretion gout; LUSC cis rs611744 0.538 rs13257548 chr8:109273185 G/A cg21045802 chr8:109455806 TTC35 0.46 7.12 0.36 6.47e-12 Dupuytren's disease; LUSC cis rs34779708 0.750 rs35032841 chr10:35312687 G/A cg04310649 chr10:35416472 CREM -0.4 -6.22 -0.32 1.52e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg15038512 chr6:170123185 PHF10 0.53 7.5 0.38 5.9e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs66887589 0.592 rs2175383 chr4:120215836 C/A cg24375607 chr4:120327624 NA 0.5 7.45 0.38 8.07e-13 Diastolic blood pressure; LUSC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg18352616 chr4:3374830 RGS12 0.32 6.28 0.33 1.03e-9 Serum sulfate level; LUSC cis rs8077889 1.000 rs2079005 chr17:41865627 T/G cg26893861 chr17:41843967 DUSP3 1.01 15.04 0.64 2.13e-39 Triglycerides; LUSC cis rs11650494 0.908 rs117853079 chr17:47421593 G/C cg08112188 chr17:47440006 ZNF652 1.22 10.05 0.48 6.07e-21 Prostate cancer; LUSC cis rs7191439 0.728 rs4238687 chr16:88788903 T/G cg02389323 chr16:88786976 FAM38A 0.88 9.09 0.45 8.81e-18 Plateletcrit; LUSC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg00290607 chr11:67383545 NA 0.31 5.78 0.3 1.74e-8 Mean corpuscular volume; LUSC cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg11657440 chr19:46296263 DMWD -0.72 -11.14 -0.52 9.88e-25 Coronary artery disease; LUSC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.22 -0.32 1.5e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg19920283 chr7:105172520 RINT1 0.6 6.28 0.33 1.04e-9 Bipolar disorder (body mass index interaction); LUSC cis rs3916 0.955 rs12828810 chr12:121152017 T/G cg27246729 chr12:121163418 ACADS 0.49 7.13 0.36 6.19e-12 Urinary metabolites (H-NMR features); LUSC cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.51 -0.38 5.61e-13 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg00071950 chr4:10020882 SLC2A9 0.56 9.51 0.46 3.77e-19 Bone mineral density; LUSC cis rs317689 0.819 rs317667 chr12:69703754 G/T cg11871910 chr12:69753446 YEATS4 0.48 6.43 0.33 4.48e-10 Response to diuretic therapy; LUSC cis rs10189230 0.967 rs13026380 chr2:222352715 G/A cg14652038 chr2:222343519 EPHA4 0.32 5.76 0.3 1.91e-8 Urate levels in lean individuals; LUSC cis rs892961 0.899 rs747482 chr17:75412109 T/C cg05865280 chr17:75406074 SEPT9 0.45 9.4 0.46 8.7e-19 Airflow obstruction; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07843583 chr10:135143563 CALY 0.74 6.34 0.33 7.25e-10 Cognitive performance; LUSC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg16524733 chr11:117070046 TAGLN 0.4 6.84 0.35 3.79e-11 Blood protein levels; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg24846343 chr22:24311635 DDTL -0.58 -9.22 -0.45 3.44e-18 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg18404041 chr3:52824283 ITIH1 0.55 9.18 0.45 4.67e-18 Schizophrenia; LUSC cis rs4629180 0.675 rs4851459 chr2:102109006 T/A cg04415270 chr2:102091202 RFX8 -0.46 -8.02 -0.4 1.86e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.5 8.02 0.4 1.84e-14 Menarche (age at onset); LUSC cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.11 0.36 7.23e-12 Cognitive ability; LUSC cis rs7091068 0.522 rs10882322 chr10:95483273 C/G cg20715218 chr10:95462985 C10orf4 0.6 7.32 0.37 1.86e-12 Urinary tract infection frequency; LUSC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg06484146 chr7:12443880 VWDE -0.72 -7.12 -0.36 6.86e-12 Coronary artery disease; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg06877462 chr1:205807181 PM20D1 0.5 9.0 0.44 1.77e-17 Menarche (age at onset); LUSC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg24531977 chr5:56204891 C5orf35 -1.02 -15.49 -0.65 3.7e-41 Initial pursuit acceleration; LUSC cis rs1042058 0.565 rs650110 chr10:30753132 A/G cg18806716 chr10:30721971 MAP3K8 -0.61 -9.82 -0.47 3.63e-20 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.01 0.4 1.9e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg23188684 chr11:67383651 NA 0.34 5.96 0.31 6.54e-9 Mean corpuscular volume; LUSC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg06221963 chr1:154839813 KCNN3 -0.61 -14.18 -0.61 4.82e-36 Prostate cancer; LUSC trans rs8002861 0.967 rs2325071 chr13:44476793 T/C cg12856521 chr11:46389249 DGKZ 0.4 6.13 0.32 2.54e-9 Leprosy; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg05397039 chr1:243419179 SDCCAG8;CEP170 0.37 6.06 0.31 3.61e-9 Triglycerides; LUSC cis rs920590 0.643 rs2083640 chr8:19660212 T/C cg03894339 chr8:19674705 INTS10 0.41 5.85 0.31 1.15e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs258324 0.720 rs154663 chr16:89726035 T/C cg04287289 chr16:89883240 FANCA -0.66 -5.85 -0.3 1.19e-8 Height; LUSC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg17143192 chr8:8559678 CLDN23 0.58 8.33 0.41 2.07e-15 Obesity-related traits; LUSC cis rs11190604 1.000 rs4919472 chr10:102315864 T/A cg16342193 chr10:102329863 NA -0.36 -6.27 -0.32 1.12e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg13010199 chr12:38710504 ALG10B 0.7 10.93 0.51 5.81e-24 Bladder cancer; LUSC cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.56 -8.94 -0.44 2.7e-17 Personality dimensions; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg11494091 chr17:61959527 GH2 0.65 13.74 0.6 2.37e-34 Prudent dietary pattern; LUSC cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs17401966 1.000 rs11121552 chr1:10435324 C/A cg19773385 chr1:10388646 KIF1B -0.55 -8.23 -0.41 4.12e-15 Hepatocellular carcinoma; LUSC cis rs17253792 0.822 rs77990307 chr14:56070049 T/C cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs1163251 0.902 rs639216 chr1:120217414 C/T cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg26769984 chr7:1090371 C7orf50 0.56 8.04 0.4 1.57e-14 Bronchopulmonary dysplasia; LUSC cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.48 0.38 6.82e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs644148 0.836 rs2571110 chr19:45000712 T/C cg15540054 chr19:45004280 ZNF180 -0.65 -9.69 -0.47 9.94e-20 Personality dimensions; LUSC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg09699651 chr6:150184138 LRP11 0.37 5.73 0.3 2.22e-8 Lung cancer; LUSC cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.68 -0.34 1.02e-10 Monocyte percentage of white cells; LUSC cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.14 0.36 5.97e-12 Cognitive ability; LUSC cis rs765787 0.530 rs7167389 chr15:45535683 A/G cg25801113 chr15:45476975 SHF 0.35 7.18 0.37 4.61e-12 Uric acid levels; LUSC trans rs7681440 0.874 rs1442151 chr4:90775491 T/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.96 -0.31 6.49e-9 Dementia with Lewy bodies; LUSC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.1 -0.36 7.78e-12 Major depressive disorder; LUSC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -7.3 -0.37 2.11e-12 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.18e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7917772 0.582 rs10786689 chr10:104356359 T/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.42 -0.38 9.5e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6964587 0.626 rs35849169 chr7:91507313 A/G cg17063962 chr7:91808500 NA 0.54 8.83 0.43 6.16e-17 Breast cancer; LUSC trans rs7980799 0.682 rs10844611 chr12:33603544 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.4 -0.33 5.29e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs60843830 0.928 rs2306060 chr2:230912 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 10.65 0.5 5.26e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4242434 0.672 rs2404654 chr8:22484949 T/C cg03733263 chr8:22462867 KIAA1967 0.77 12.69 0.57 2.29e-30 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs897080 0.515 rs1067337 chr2:44624859 A/G cg00619915 chr2:44497795 NA -0.41 -5.82 -0.3 1.35e-8 Height; LUSC cis rs6430585 0.591 rs724326 chr2:136485971 T/C cg07169764 chr2:136633963 MCM6 0.83 10.63 0.5 6.49e-23 Corneal structure; LUSC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -5.85 -0.3 1.16e-8 Calcium levels; LUSC cis rs12940923 0.748 rs56298529 chr17:56363859 T/A cg19466818 chr17:56409534 MIR142 -0.38 -6.74 -0.35 7.07e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs9644630 0.930 rs6586840 chr8:19365832 C/T cg01280390 chr8:19363452 CSGALNACT1 -0.36 -6.75 -0.35 6.62e-11 Oropharynx cancer; LUSC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs950776 0.507 rs12912673 chr15:78810216 T/C cg06917634 chr15:78832804 PSMA4 0.82 14.69 0.63 4.94e-38 Sudden cardiac arrest; LUSC cis rs2235573 0.551 rs84770 chr22:38390128 T/G cg06521852 chr22:38141419 TRIOBP -0.34 -5.71 -0.3 2.47e-8 Glioblastoma;Glioma; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg12419862 chr22:24373484 LOC391322 -1.03 -22.02 -0.77 5.16e-67 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg15448220 chr1:150897856 SETDB1 0.41 5.88 0.31 9.89e-9 Melanoma; LUSC cis rs1448094 0.717 rs7137122 chr12:86290702 T/C cg02569458 chr12:86230093 RASSF9 0.53 8.56 0.42 4.18e-16 Major depressive disorder; LUSC cis rs9311676 0.632 rs12487420 chr3:58399511 A/G cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs2235642 0.750 rs2859310 chr16:1656765 C/T cg09025071 chr16:1593152 IFT140;TMEM204 -0.32 -7.52 -0.38 5.12e-13 Coronary artery disease; LUSC cis rs7937682 0.883 rs1613778 chr11:111456105 G/C cg22437258 chr11:111473054 SIK2 0.51 7.05 0.36 1e-11 Primary sclerosing cholangitis; LUSC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg22508957 chr16:3507546 NAT15 -0.76 -9.53 -0.46 3.24e-19 Tuberculosis; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg02624855 chr19:41111297 LTBP4 0.4 6.02 0.31 4.58e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg11845111 chr2:191398756 TMEM194B 0.59 9.82 0.47 3.56e-20 Pulse pressure; LUSC cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg12011299 chr4:100065546 ADH4 -0.69 -10.72 -0.51 3.17e-23 Alcohol dependence; LUSC cis rs7267979 1.000 rs12428 chr20:25433821 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.07 -0.72 2.2e-55 Liver enzyme levels (alkaline phosphatase); LUSC cis rs34638657 0.500 rs7405197 chr16:82169833 C/A cg09439754 chr16:82129088 HSD17B2 -0.37 -6.84 -0.35 3.73e-11 Lung adenocarcinoma; LUSC cis rs2795502 0.873 rs2795527 chr10:43270240 T/C cg20628663 chr10:43360327 NA -0.64 -8.09 -0.4 1.14e-14 Blood protein levels; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg26005766 chr6:125475650 TPD52L1 0.38 6.11 0.32 2.74e-9 Schizophrenia (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19867517 chr1:224622813 WDR26 0.69 6.26 0.32 1.19e-9 Cognitive performance; LUSC cis rs240764 0.580 rs4839789 chr6:101233235 T/A cg09795085 chr6:101329169 ASCC3 -0.45 -6.46 -0.33 3.75e-10 Neuroticism; LUSC cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg16586182 chr3:47516702 SCAP -0.51 -8.0 -0.4 2e-14 Colorectal cancer; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg18190219 chr22:46762943 CELSR1 0.49 6.67 0.34 1.04e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs2076346 0.638 rs571479 chr1:24053465 A/T cg10978503 chr1:24200527 CNR2 0.3 5.94 0.31 7.06e-9 Inflammatory skin disease; LUSC cis rs4595586 0.545 rs925828 chr12:39364222 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg21862992 chr11:68658383 NA 0.52 8.03 0.4 1.63e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11971779 0.680 rs6962637 chr7:139051350 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.28 -0.32 1.07e-9 Alzheimer's disease (late onset); LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg08888203 chr3:10149979 C3orf24 0.59 7.98 0.4 2.29e-14 Alzheimer's disease; LUSC cis rs11603020 0.950 rs3824988 chr11:57377968 C/T cg23127183 chr11:57508653 C11orf31 0.45 6.24 0.32 1.34e-9 Blood protein levels; LUSC cis rs477692 0.699 rs528549 chr10:131381574 A/G cg26102564 chr10:131424627 MGMT 0.38 5.72 0.3 2.36e-8 Response to temozolomide; LUSC cis rs9309473 0.519 rs6730785 chr2:73642403 A/C cg20560298 chr2:73613845 ALMS1 0.48 7.4 0.38 1.1e-12 Metabolite levels; LUSC cis rs10883723 0.962 rs1056739 chr10:104236542 T/C cg05855489 chr10:104503620 C10orf26 -0.69 -9.87 -0.48 2.54e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6665290 0.566 rs1513617 chr1:227447213 C/T cg10327440 chr1:227177885 CDC42BPA 0.98 16.79 0.68 2.68e-46 Myeloid white cell count; LUSC cis rs11098499 0.569 rs55845118 chr4:120290913 T/C cg24375607 chr4:120327624 NA 0.69 10.58 0.5 9.19e-23 Corneal astigmatism; LUSC cis rs6696846 0.729 rs72757512 chr1:205079203 G/A cg03948781 chr1:205179583 DSTYK 0.33 6.46 0.33 3.63e-10 Red blood cell count; LUSC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg04369109 chr6:150039330 LATS1 -0.57 -8.49 -0.42 6.66e-16 Lung cancer; LUSC cis rs61542988 0.570 rs10950919 chr7:22833821 A/G cg11367502 chr7:22862612 TOMM7 0.48 5.84 0.3 1.27e-8 Fibrinogen levels; LUSC cis rs7582720 1.000 rs75141346 chr2:203685119 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 7.97 0.4 2.46e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs701145 0.556 rs355763 chr3:154012881 C/T cg10247383 chr3:153839028 SGEF -0.47 -5.79 -0.3 1.61e-8 Coronary artery disease; LUSC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg22800045 chr5:56110881 MAP3K1 0.77 9.63 0.47 1.5700000000000001e-19 Initial pursuit acceleration; LUSC cis rs72634258 0.945 rs7522911 chr1:8097145 C/T cg26816564 chr1:7831052 VAMP3 0.49 5.93 0.31 7.64e-9 Inflammatory bowel disease; LUSC cis rs7131987 0.621 rs6487805 chr12:29457550 A/T cg09582351 chr12:29534625 ERGIC2 0.33 6.63 0.34 1.34e-10 QT interval; LUSC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -5.71 -0.3 2.49e-8 Developmental language disorder (linguistic errors); LUSC cis rs4077515 0.874 rs10781505 chr9:139271355 C/T cg14169450 chr9:139327907 INPP5E -0.41 -7.35 -0.37 1.54e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs80130819 0.688 rs4760692 chr12:48587549 T/C cg24011408 chr12:48396354 COL2A1 0.45 5.89 0.31 9.18e-9 Prostate cancer; LUSC cis rs727505 1.000 rs10264060 chr7:124486413 C/A cg23710748 chr7:124431027 NA -0.41 -7.46 -0.38 7.78e-13 Lewy body disease; LUSC cis rs1419980 0.630 rs2377089 chr12:7737325 T/C cg10578777 chr12:7781093 NA 0.54 5.96 0.31 6.58e-9 HDL cholesterol levels; LUSC cis rs1670533 0.769 rs6814833 chr4:1057679 A/C cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC cis rs9303401 0.659 rs35082010 chr17:56936867 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.18 0.58 3.19e-32 Cognitive test performance; LUSC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg07148914 chr20:33460835 GGT7 0.54 8.25 0.41 3.73e-15 Height; LUSC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg07473001 chr8:73920952 TERF1 0.5 6.21 0.32 1.56e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6918586 0.658 rs198803 chr6:26135052 T/A cg17691542 chr6:26056736 HIST1H1C 0.41 6.05 0.31 3.81e-9 Schizophrenia; LUSC cis rs7106204 0.609 rs12791360 chr11:24286239 T/G ch.11.24196551F chr11:24239977 NA 0.69 5.98 0.31 5.82e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7107174 1.000 rs10899458 chr11:78007451 A/T cg02023728 chr11:77925099 USP35 0.49 6.87 0.35 3.11e-11 Testicular germ cell tumor; LUSC cis rs1577917 1.000 rs9647603 chr6:86639341 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs7759001 0.857 rs6903254 chr6:27362359 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg05855489 chr10:104503620 C10orf26 0.53 7.8 0.39 7.97e-14 Arsenic metabolism; LUSC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg10802521 chr3:52805072 NEK4 -0.52 -8.38 -0.42 1.51e-15 Bipolar disorder; LUSC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 10.78 0.51 1.82e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4588572 0.643 rs1019803 chr5:77739154 A/G cg11547950 chr5:77652471 NA -0.55 -7.61 -0.38 2.81e-13 Triglycerides; LUSC cis rs8060686 0.641 rs75796305 chr16:68208791 A/G cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs3733585 0.699 rs62294332 chr4:9959989 T/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11603020 0.851 rs10896631 chr11:57381263 T/C cg23127183 chr11:57508653 C11orf31 -0.47 -6.57 -0.34 1.95e-10 Blood protein levels; LUSC trans rs1994135 0.654 rs1384591 chr12:33734170 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.46 0.33 3.7e-10 Resting heart rate; LUSC cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.49 -5.67 -0.3 3.13e-8 Schizophrenia; LUSC trans rs10511400 0.618 rs6438562 chr3:119870132 C/T cg02809009 chr19:50354510 PTOV1 -0.67 -6.16 -0.32 2.06e-9 Economic and political preferences (feminism/equality); LUSC cis rs1775715 0.737 rs2808072 chr10:32205504 A/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.45 0.33 3.88e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2522056 1.000 rs7730247 chr5:131781288 A/C cg24060327 chr5:131705240 SLC22A5 0.48 6.72 0.34 8.09e-11 Lymphocyte counts;Fibrinogen; LUSC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg26924012 chr15:45694286 SPATA5L1 1.13 20.81 0.75 2.85e-62 Homoarginine levels; LUSC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg08219700 chr8:58056026 NA 0.47 5.94 0.31 7.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg13560548 chr3:10150139 C3orf24 0.53 7.43 0.38 9.1e-13 Alzheimer's disease; LUSC cis rs4629180 0.675 rs10195061 chr2:102093974 T/G cg04415270 chr2:102091202 RFX8 -0.46 -7.91 -0.4 3.88e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs4766566 0.609 rs1344438 chr12:111735954 C/G cg10833066 chr12:111807467 FAM109A 0.55 10.24 0.49 1.39e-21 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC trans rs10435719 0.580 rs13260712 chr8:11782570 A/C cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.46e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7131987 0.903 rs7308125 chr12:29425211 T/C cg09582351 chr12:29534625 ERGIC2 -0.32 -6.63 -0.34 1.34e-10 QT interval; LUSC cis rs11098499 0.909 rs28793658 chr4:120307214 A/C cg24375607 chr4:120327624 NA 0.77 11.4 0.53 1.16e-25 Corneal astigmatism; LUSC cis rs2180341 0.618 rs11154396 chr6:127638911 C/T cg27446573 chr6:127587934 RNF146 0.64 10.41 0.5 3.59e-22 Breast cancer; LUSC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg06873352 chr17:61820015 STRADA 0.56 8.69 0.43 1.7e-16 Height; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg06873352 chr17:61820015 STRADA 0.72 12.98 0.58 1.83e-31 Prudent dietary pattern; LUSC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg00815214 chr21:47717953 NA -0.42 -6.29 -0.33 9.95e-10 Testicular germ cell tumor; LUSC cis rs854765 0.583 rs67253360 chr17:17828973 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.28 0.59 1.28e-32 Total body bone mineral density; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25833238 chr6:153304325 FBXO5 -0.48 -6.72 -0.35 8.08e-11 Bipolar disorder and schizophrenia; LUSC cis rs734999 0.545 rs6666430 chr1:2698950 G/A cg18854424 chr1:2615690 NA 0.48 9.39 0.46 9.32e-19 Ulcerative colitis; LUSC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.44 9.05 0.44 1.2e-17 Autism spectrum disorder or schizophrenia; LUSC trans rs3858145 0.588 rs55888445 chr10:70036456 C/T cg04882175 chr6:131122610 NA -0.65 -8.71 -0.43 1.4e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC cis rs6596100 0.538 rs17594964 chr5:132188712 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.02 -0.31 4.6e-9 Breast cancer; LUSC cis rs9400467 0.508 rs11756643 chr6:111726146 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.89 -0.35 2.72e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs11756438 0.572 rs2638552 chr6:118999412 C/T cg18833306 chr6:118973337 C6orf204 0.36 5.73 0.3 2.2e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7584330 0.554 rs10173100 chr2:238433040 A/G cg16989719 chr2:238392110 NA -0.39 -5.69 -0.3 2.79e-8 Prostate cancer; LUSC cis rs2046867 0.818 rs62249879 chr3:72917171 A/G cg25664220 chr3:72788482 NA -0.63 -10.42 -0.5 3.27e-22 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7084921 0.552 rs2862991 chr10:101876736 C/G cg02250046 chr10:101825185 CPN1 -0.3 -5.66 -0.3 3.32e-8 Bone mineral density; LUSC cis rs9807841 0.568 rs1560707 chr19:10750738 A/C cg17710535 chr19:10819994 QTRT1 0.41 6.82 0.35 4.38e-11 Inflammatory skin disease; LUSC cis rs868036 0.609 rs2045960 chr15:68092079 G/A cg05925327 chr15:68127851 NA -0.47 -7.35 -0.37 1.54e-12 Restless legs syndrome; LUSC cis rs4629710 0.592 rs13200165 chr6:131549167 G/C cg12700074 chr6:131571435 AKAP7 -0.36 -6.02 -0.31 4.65e-9 Multiple myeloma (IgH translocation); LUSC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg27535305 chr1:53392650 SCP2 -0.41 -7.61 -0.38 2.8e-13 Monocyte count; LUSC cis rs11997175 0.546 rs4733448 chr8:33628575 G/A ch.8.33884649F chr8:33765107 NA 0.51 8.17 0.41 6.62e-15 Body mass index; LUSC cis rs6815814 0.808 rs11721824 chr4:38767749 G/A cg02016764 chr4:38805732 TLR1 -0.53 -5.79 -0.3 1.65e-8 Breast cancer; LUSC cis rs886126 0.901 rs4766557 chr12:111664044 G/C cg10833066 chr12:111807467 FAM109A 0.4 6.36 0.33 6.74e-10 Coronary heart disease; LUSC cis rs7577696 0.626 rs212754 chr2:32421628 A/G cg02381751 chr2:32503542 YIPF4 0.53 7.1 0.36 7.62e-12 Inflammatory biomarkers; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg24060327 chr5:131705240 SLC22A5 0.65 11.23 0.52 4.87e-25 Breast cancer; LUSC cis rs7804356 1.000 rs12536560 chr7:26822876 G/C cg03456212 chr7:26904342 SKAP2 -0.56 -6.63 -0.34 1.36e-10 Type 1 diabetes; LUSC cis rs4964805 0.802 rs934847 chr12:104185693 C/T cg02344784 chr12:104178138 NT5DC3 0.44 7.1 0.36 7.43e-12 Attention deficit hyperactivity disorder; LUSC cis rs8141529 0.764 rs5752812 chr22:29225603 T/A cg02153584 chr22:29168773 CCDC117 0.66 10.6 0.5 8e-23 Lymphocyte counts; LUSC cis rs12893668 0.703 rs35026580 chr14:104042753 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -6.49 -0.33 3.08e-10 Reticulocyte count; LUSC cis rs9926296 0.656 rs4522419 chr16:89853307 T/C cg04287289 chr16:89883240 FANCA 0.5 7.26 0.37 2.81e-12 Vitiligo; LUSC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.05 -0.31 3.94e-9 Alzheimer's disease (late onset); LUSC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg12257692 chr3:49977190 RBM6 -0.26 -7.22 -0.37 3.46e-12 Intelligence (multi-trait analysis); LUSC cis rs7223966 1.000 rs9895920 chr17:61852719 T/C cg00945038 chr17:61921165 SMARCD2 0.4 6.02 0.31 4.51e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg18402987 chr7:1209562 NA 0.71 7.53 0.38 4.64e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7605827 0.930 rs3954894 chr2:15517656 T/C cg19274914 chr2:15703543 NA 0.47 9.2 0.45 4.07e-18 Educational attainment (years of education); LUSC cis rs500891 0.830 rs28360575 chr6:84138270 G/A cg08257003 chr6:84140564 ME1 0.35 7.27 0.37 2.56e-12 Platelet-derived growth factor BB levels; LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg07157834 chr1:205819609 PM20D1 0.81 13.95 0.61 3.6e-35 Menarche (age at onset); LUSC cis rs1215050 0.791 rs9993992 chr4:98810851 C/G cg05340658 chr4:99064831 C4orf37 0.44 6.88 0.35 3.05e-11 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg21548813 chr6:291882 DUSP22 -0.71 -11.59 -0.54 2.56e-26 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16636153 chr7:5553333 FBXL18 -0.41 -6.28 -0.32 1.04e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg27535305 chr1:53392650 SCP2 -0.36 -6.7 -0.34 8.74e-11 Monocyte count; LUSC cis rs7568458 0.837 rs6547624 chr2:85802134 A/T cg17127132 chr2:85788382 GGCX 0.48 7.67 0.39 1.91e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3820928 0.839 rs35068645 chr2:227844265 T/C cg11843606 chr2:227700838 RHBDD1 -0.51 -7.4 -0.38 1.13e-12 Pulmonary function; LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg27170947 chr2:26402098 FAM59B -0.7 -10.76 -0.51 2.29e-23 Gut microbiome composition (summer); LUSC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17890828 chr19:36103534 HAUS5 -0.56 -7.02 -0.36 1.23e-11 Bipolar disorder and schizophrenia; LUSC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg18240062 chr17:79603768 NPLOC4 0.79 15.25 0.64 3.23e-40 Eye color traits; LUSC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg23283495 chr1:209979779 IRF6 0.73 9.34 0.46 1.37e-18 Cleft lip with or without cleft palate; LUSC cis rs6754311 0.731 rs3769005 chr2:136603366 C/G cg25344623 chr2:136566232 LCT 0.38 5.71 0.3 2.55e-8 Mosquito bite size; LUSC cis rs13242816 1.000 rs34325296 chr7:116122409 C/T cg16553024 chr7:116138462 CAV2 -0.52 -5.68 -0.3 2.89e-8 P wave duration; LUSC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg06494592 chr3:125709126 NA -0.5 -5.77 -0.3 1.86e-8 Blood pressure (smoking interaction); LUSC cis rs897984 0.609 rs17839567 chr16:31057945 A/G cg02466173 chr16:30829666 NA -0.53 -10.36 -0.49 5.4e-22 Dementia with Lewy bodies; LUSC cis rs7584330 0.554 rs13431733 chr2:238430275 A/G cg16989719 chr2:238392110 NA -0.41 -5.75 -0.3 2.01e-8 Prostate cancer; LUSC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg24733560 chr20:60626293 TAF4 0.43 6.92 0.35 2.25e-11 Body mass index; LUSC cis rs2274273 0.868 rs1572611 chr14:55833874 T/A cg04306507 chr14:55594613 LGALS3 0.54 11.9 0.55 1.87e-27 Protein biomarker; LUSC cis rs61931739 0.534 rs11052957 chr12:33995354 G/A cg06521331 chr12:34319734 NA -0.46 -7.53 -0.38 4.69e-13 Morning vs. evening chronotype; LUSC cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg09184832 chr6:79620586 NA -0.44 -7.06 -0.36 9.88e-12 Intelligence (multi-trait analysis); LUSC cis rs2414856 0.510 rs72758914 chr15:64643203 C/T cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs5769707 0.681 rs739240 chr22:50052607 C/A cg05373962 chr22:49881684 NA -0.4 -8.44 -0.42 9.44e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg04455712 chr21:45112962 RRP1B 0.45 8.46 0.42 8.61e-16 Mean corpuscular volume; LUSC cis rs9309473 0.898 rs10197755 chr2:73797623 T/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.53 -0.34 2.47e-10 Metabolite levels; LUSC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.94 0.4 3.18e-14 Bipolar disorder; LUSC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg07636037 chr3:49044803 WDR6 1.05 19.21 0.72 6.06e-56 Parkinson's disease; LUSC cis rs929354 1.000 rs1182385 chr7:157040583 C/T cg05182265 chr7:156933206 UBE3C 0.48 7.37 0.37 1.33e-12 Body mass index; LUSC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg18252515 chr7:66147081 NA 1.21 13.5 0.59 1.92e-33 Diabetic kidney disease; LUSC cis rs2839186 0.749 rs62226488 chr21:47710517 C/T cg05896524 chr21:47604654 C21orf56 0.4 5.84 0.3 1.24e-8 Testicular germ cell tumor; LUSC cis rs10078 0.571 rs2721028 chr5:443849 A/G cg24955955 chr5:415729 AHRR 0.62 5.7 0.3 2.6e-8 Fat distribution (HIV); LUSC cis rs909341 0.810 rs2427529 chr20:62359564 T/A cg09650180 chr20:62225654 GMEB2 -0.47 -6.11 -0.32 2.75e-9 Atopic dermatitis; LUSC cis rs1577917 0.916 rs4142546 chr6:86505311 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.83 -0.43 6.07e-17 Response to antipsychotic treatment; LUSC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg18827107 chr12:86230957 RASSF9 0.45 6.91 0.35 2.45e-11 Major depressive disorder; LUSC cis rs4285028 0.948 rs71329246 chr3:121680170 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.68 -0.47 1.07e-19 Multiple sclerosis; LUSC cis rs9311676 0.632 rs62259779 chr3:58425692 C/G cg26110898 chr3:58419937 PDHB 0.39 6.33 0.33 7.88e-10 Systemic lupus erythematosus; LUSC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg15649852 chr7:65879115 NA -0.41 -5.64 -0.3 3.53e-8 Aortic root size; LUSC cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.83e-11 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.49 -0.33 3.13e-10 Lung cancer; LUSC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg07777224 chr19:58919807 ZNF584 -0.43 -5.83 -0.3 1.3e-8 Uric acid clearance; LUSC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -10.12 -0.48 3.7e-21 Autism spectrum disorder or schizophrenia; LUSC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.7 -10.64 -0.5 5.91e-23 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7927771 0.864 rs10838724 chr11:47527052 G/T cg20135002 chr11:47629003 NA -0.47 -7.44 -0.38 8.7e-13 Subjective well-being; LUSC cis rs3733631 1.000 rs3796951 chr4:104628158 A/T cg24090629 chr4:104641072 TACR3 0.45 5.83 0.3 1.29e-8 Menarche (age at onset); LUSC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg22800045 chr5:56110881 MAP3K1 0.78 9.56 0.46 2.6e-19 Initial pursuit acceleration; LUSC cis rs208520 0.661 rs150263 chr6:66777620 T/C cg07460842 chr6:66804631 NA -1.13 -17.73 -0.7 5.05e-50 Exhaled nitric oxide output; LUSC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg27129171 chr3:47204927 SETD2 -0.71 -12.5 -0.56 1.12e-29 Colorectal cancer; LUSC cis rs1577917 0.958 rs6921315 chr6:86471668 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.48 -0.33 3.39e-10 Response to antipsychotic treatment; LUSC trans rs61931739 0.782 rs451940 chr12:34196005 T/C cg13010199 chr12:38710504 ALG10B 0.42 6.66 0.34 1.13e-10 Morning vs. evening chronotype; LUSC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg12560992 chr17:57184187 TRIM37 0.84 15.05 0.64 1.94e-39 Intelligence (multi-trait analysis); LUSC cis rs2108225 0.837 rs6959729 chr7:107446180 A/C cg18560240 chr7:107437656 SLC26A3 -0.47 -7.25 -0.37 2.9e-12 Ulcerative colitis; LUSC cis rs61931739 0.500 rs11053218 chr12:34474792 A/C cg06521331 chr12:34319734 NA 0.4 6.21 0.32 1.62e-9 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20284025 chr1:119683198 WARS2 -0.47 -7.09 -0.36 8.17e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg11245181 chr6:149772854 ZC3H12D -0.3 -6.62 -0.34 1.46e-10 Dupuytren's disease; LUSC cis rs11997175 0.522 rs10954930 chr8:33588352 C/T ch.8.33884649F chr8:33765107 NA 0.49 7.72 0.39 1.33e-13 Body mass index; LUSC trans rs11098499 0.863 rs3733525 chr4:120447048 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.59 0.38 3.3e-13 Corneal astigmatism; LUSC cis rs7247513 0.964 rs12104149 chr19:12721088 A/G cg01871581 chr19:12707946 ZNF490 -0.61 -9.89 -0.48 2.12e-20 Bipolar disorder; LUSC cis rs7119 0.717 rs12910594 chr15:77817103 G/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.47 6.84 0.35 3.69e-11 Schizophrenia; LUSC cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg20908204 chr19:46285434 DMPK -0.46 -8.71 -0.43 1.42e-16 Coronary artery disease; LUSC cis rs2692947 0.696 rs1724121 chr2:96808549 T/C cg22654517 chr2:96458247 NA 0.37 7.39 0.38 1.16e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg19622623 chr12:86230825 RASSF9 0.4 5.72 0.3 2.33e-8 Major depressive disorder; LUSC cis rs4566357 0.595 rs10206912 chr2:227921095 A/T cg11843606 chr2:227700838 RHBDD1 -0.5 -7.45 -0.38 7.94e-13 Coronary artery disease; LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7582180 0.629 rs4851295 chr2:100945605 T/C cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg16362232 chr11:430036 ANO9 0.66 8.14 0.41 7.66e-15 Body mass index; LUSC cis rs9308433 0.529 rs4655336 chr1:214499667 A/C cg06198575 chr1:214491504 SMYD2 0.45 7.06 0.36 9.75e-12 IgG glycosylation; LUSC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg05234568 chr11:5960015 NA -0.6 -8.7 -0.43 1.55e-16 DNA methylation (variation); LUSC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs12908161 1.000 rs12908161 chr15:85207825 A/G cg17507749 chr15:85114479 UBE2QP1 0.56 6.76 0.35 6.35e-11 Schizophrenia; LUSC cis rs9948 0.786 rs62156227 chr2:97417942 C/A cg01990225 chr2:97406019 LMAN2L -0.78 -5.86 -0.31 1.1e-8 Erectile dysfunction and prostate cancer treatment; LUSC cis rs11690935 0.959 rs7604918 chr2:172588094 G/A cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.65 -0.63 6.79e-38 Schizophrenia; LUSC cis rs7940866 0.838 rs1118137 chr11:130890970 G/A cg12179176 chr11:130786555 SNX19 0.63 9.86 0.47 2.62e-20 Schizophrenia; LUSC cis rs10740039 1.000 rs10821818 chr10:62416936 C/T cg18175470 chr10:62150864 ANK3 -0.43 -6.8 -0.35 4.8e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs3820928 0.874 rs10210963 chr2:227821845 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.67 -0.39 1.95e-13 Pulmonary function; LUSC cis rs1044826 0.597 rs6772199 chr3:139178133 C/T cg00490450 chr3:139108681 COPB2 0.45 7.05 0.36 1.05e-11 Obesity-related traits; LUSC cis rs56399783 0.901 rs55767077 chr7:2774608 C/T cg19731401 chr7:2775893 GNA12 0.74 8.92 0.44 3.18e-17 Childhood ear infection; LUSC cis rs11997175 0.574 rs58858314 chr8:33658221 T/C ch.8.33884649F chr8:33765107 NA 0.51 8.36 0.42 1.69e-15 Body mass index; LUSC trans rs724744 0.742 rs1205937 chr6:22357993 A/C cg13807341 chr11:118445984 ARCN1 -0.35 -5.96 -0.31 6.54e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC trans rs3784262 0.528 rs1994926 chr15:58334587 C/T cg04124740 chr17:64400691 PRKCA 0.31 5.95 0.31 6.73e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs2224391 0.628 rs2773310 chr6:5250828 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.59 -0.34 1.75e-10 Height; LUSC cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg19622623 chr12:86230825 RASSF9 -0.44 -6.27 -0.32 1.11e-9 Major depressive disorder; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg07703079 chr11:430292 ANO9 0.61 6.64 0.34 1.26e-10 Body mass index; LUSC cis rs10193935 1.000 rs72796507 chr2:42409840 A/G cg27598129 chr2:42591480 NA -0.58 -7.8 -0.39 7.83e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs561341 1.000 rs506766 chr17:30289659 T/C cg27661571 chr11:113659931 NA -0.71 -7.94 -0.4 3.05e-14 Hip circumference adjusted for BMI; LUSC cis rs7568458 0.709 rs1446669 chr2:85762209 T/C cg02493740 chr2:85810744 VAMP5 -0.5 -8.67 -0.43 1.92e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6076065 0.723 rs2424552 chr20:23402833 G/A cg11657817 chr20:23433608 CST11 0.42 7.44 0.38 8.44e-13 Facial morphology (factor 15, philtrum width); LUSC cis rs4629710 0.592 rs11759793 chr6:131546384 G/A cg12606694 chr6:131520996 AKAP7 0.62 9.44 0.46 6.45e-19 Multiple myeloma (IgH translocation); LUSC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg09085632 chr11:111637200 PPP2R1B -1.05 -17.02 -0.68 3.39e-47 Primary sclerosing cholangitis; LUSC cis rs561341 0.739 rs9906455 chr17:30215669 G/A cg00745463 chr17:30367425 LRRC37B 0.57 7.2 0.37 4.07e-12 Hip circumference adjusted for BMI; LUSC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg14552801 chr7:65878734 NA -0.37 -5.73 -0.3 2.19e-8 Aortic root size; LUSC cis rs6005807 0.588 rs6519751 chr22:28845498 G/T cg12565055 chr22:29076175 TTC28 0.48 5.7 0.3 2.65e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs7904985 1.000 rs10887586 chr10:88113521 G/A cg07322936 chr10:88137208 NA -0.56 -7.05 -0.36 1.05e-11 Barrett's esophagus; LUSC cis rs6722750 0.782 rs7608530 chr2:64412043 T/A cg22352474 chr2:64371530 PELI1 -0.5 -7.24 -0.37 3.19e-12 Neuroticism; LUSC cis rs7937682 0.924 rs1784782 chr11:111525764 A/C cg22437258 chr11:111473054 SIK2 0.51 6.91 0.35 2.42e-11 Primary sclerosing cholangitis; LUSC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg19346786 chr7:2764209 NA -0.49 -8.35 -0.42 1.9e-15 Height; LUSC cis rs9463078 0.526 rs1159131 chr6:44972209 T/C cg25276700 chr6:44698697 NA 0.29 6.1 0.32 3e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7727544 0.582 rs6896703 chr5:131521295 C/G cg14196790 chr5:131705035 SLC22A5 -0.48 -7.71 -0.39 1.42e-13 Blood metabolite levels; LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.98 -0.52 3.66e-24 Alzheimer's disease; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg19318889 chr4:1322082 MAEA -0.48 -7.76 -0.39 1.02e-13 Obesity-related traits; LUSC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg05623727 chr3:50126028 RBM5 -0.34 -6.24 -0.32 1.34e-9 Intelligence (multi-trait analysis); LUSC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg00129232 chr17:37814104 STARD3 -0.5 -7.48 -0.38 6.46e-13 Asthma; LUSC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.6 -0.43 3.08e-16 Personality dimensions; LUSC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg13047869 chr3:10149882 C3orf24 0.42 6.44 0.33 4.21e-10 Alzheimer's disease; LUSC trans rs9393777 0.920 rs67859638 chr6:27357978 A/G cg06606381 chr12:133084897 FBRSL1 -0.99 -8.61 -0.43 2.87e-16 Intelligence (multi-trait analysis); LUSC cis rs929596 0.785 rs17862875 chr2:234649302 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.71 -12.11 -0.55 3.22e-28 Total bilirubin levels in HIV-1 infection; LUSC trans rs7937682 0.961 rs7106104 chr11:111635655 T/C cg18187862 chr3:45730750 SACM1L -0.6 -7.48 -0.38 6.71e-13 Primary sclerosing cholangitis; LUSC cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg26597838 chr10:835615 NA 0.64 8.05 0.4 1.46e-14 Eosinophil percentage of granulocytes; LUSC cis rs12286929 0.802 rs12787954 chr11:115020328 T/C cg04055981 chr11:115044050 NA 0.34 5.76 0.3 1.95e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1595825 0.891 rs16866980 chr2:198513009 A/C cg19156104 chr2:198669113 PLCL1 -0.46 -5.78 -0.3 1.69e-8 Ulcerative colitis; LUSC cis rs7246657 0.943 rs2045908 chr19:37979768 C/G cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs1670533 1.000 rs6821725 chr4:1060360 C/G cg02018176 chr4:1364513 KIAA1530 0.43 5.9 0.31 8.71e-9 Recombination rate (females); LUSC cis rs7917772 0.582 rs6584512 chr10:104329685 A/G cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1595825 0.679 rs3792157 chr2:198416859 G/A cg00982548 chr2:198649783 BOLL -0.52 -5.99 -0.31 5.3e-9 Ulcerative colitis; LUSC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg22800045 chr5:56110881 MAP3K1 0.61 8.71 0.43 1.45e-16 Initial pursuit acceleration; LUSC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg00677455 chr12:58241039 CTDSP2 0.59 8.48 0.42 7.35e-16 Multiple sclerosis; LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg06145435 chr7:1022769 CYP2W1 0.27 5.83 0.3 1.33e-8 Longevity;Endometriosis; LUSC trans rs12310956 0.532 rs11052951 chr12:33986181 T/A cg13010199 chr12:38710504 ALG10B 0.48 7.33 0.37 1.73e-12 Morning vs. evening chronotype; LUSC cis rs244293 0.730 rs9898020 chr17:53057715 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.38 -5.71 -0.3 2.54e-8 Menarche (age at onset); LUSC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg16506815 chr2:162101123 NA 0.42 6.28 0.32 1.06e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs72634258 0.503 rs697675 chr1:7838113 A/C cg26816564 chr1:7831052 VAMP3 0.94 13.56 0.6 1.14e-33 Inflammatory bowel disease; LUSC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg13206674 chr6:150067644 NUP43 0.64 10.44 0.5 2.78e-22 Lung cancer; LUSC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg06238570 chr21:40685208 BRWD1 -0.58 -9.02 -0.44 1.51e-17 Menarche (age at onset); LUSC cis rs782590 0.935 rs2627776 chr2:55873301 T/A cg03859395 chr2:55845619 SMEK2 0.88 16.46 0.67 5.44e-45 Metabolic syndrome; LUSC trans rs3808502 0.525 rs13280813 chr8:11425105 G/T cg06636001 chr8:8085503 FLJ10661 -0.62 -9.19 -0.45 4.28e-18 Neuroticism; LUSC cis rs77741769 0.549 rs57697145 chr12:121333552 T/G cg02419362 chr12:121203948 SPPL3 0.46 8.71 0.43 1.42e-16 Mean corpuscular volume; LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg02475777 chr4:1388615 CRIPAK 0.46 6.77 0.35 5.88e-11 Obesity-related traits; LUSC trans rs7937682 0.961 rs4936682 chr11:111629743 T/G cg18187862 chr3:45730750 SACM1L -0.61 -7.52 -0.38 5.26e-13 Primary sclerosing cholangitis; LUSC cis rs4148883 0.645 rs2851264 chr4:100029715 C/T cg12011299 chr4:100065546 ADH4 0.48 7.92 0.4 3.63e-14 Alcohol dependence; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.65 0.39 2.21e-13 Prudent dietary pattern; LUSC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.29 0.45 2.02e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg07507251 chr3:52567010 NT5DC2 0.43 9.04 0.44 1.26e-17 Electroencephalogram traits; LUSC cis rs478304 0.903 rs61895677 chr11:65549415 T/C cg05805236 chr11:65401703 PCNXL3 0.39 6.63 0.34 1.33e-10 Acne (severe); LUSC cis rs1577917 0.958 rs12213331 chr6:86504797 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.76 -0.43 9.88e-17 Response to antipsychotic treatment; LUSC cis rs727505 1.000 rs7791430 chr7:124429953 G/T cg23710748 chr7:124431027 NA -0.43 -7.72 -0.39 1.33e-13 Lewy body disease; LUSC cis rs4290604 0.748 rs4663241 chr2:238085960 T/C cg23555395 chr2:238036564 NA -0.46 -6.23 -0.32 1.4e-9 Asthma; LUSC cis rs2953174 0.744 rs2975748 chr2:241518989 A/G cg07929629 chr2:241523174 NA 0.54 8.11 0.41 1e-14 Bipolar disorder; LUSC cis rs6138458 1.000 rs11906373 chr20:24938832 A/G cg26195577 chr20:24973756 C20orf3 1.11 18.17 0.71 8.49e-52 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11653406 chr1:40367713 MYCL1 -0.48 -7.1 -0.36 7.7e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.8 -0.39 7.87e-14 Blood metabolite levels; LUSC cis rs7927771 0.839 rs3817334 chr11:47650993 C/T cg05585544 chr11:47624801 NA -0.35 -6.32 -0.33 8.52e-10 Subjective well-being; LUSC cis rs193541 0.626 rs4343835 chr5:122088731 C/T cg19077854 chr5:122220652 SNX24 -0.27 -6.14 -0.32 2.31e-9 Glucose homeostasis traits; LUSC cis rs17401966 1.000 rs35766535 chr1:10284659 T/C cg19773385 chr1:10388646 KIF1B -0.54 -8.31 -0.41 2.52e-15 Hepatocellular carcinoma; LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs559928 1.000 rs72924202 chr11:64133228 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.69 7.27 0.37 2.53e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4664304 0.772 rs17830558 chr2:160878364 A/C cg03641300 chr2:160917029 PLA2R1 -0.39 -6.32 -0.33 8.23e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg12935359 chr14:103987150 CKB 0.65 10.62 0.5 6.78e-23 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg02951883 chr7:2050386 MAD1L1 0.58 10.55 0.5 1.24e-22 Bipolar disorder and schizophrenia; LUSC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.08 -0.48 4.71e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs2514895 0.660 rs56160070 chr11:127112022 C/G cg22738642 chr12:43137977 NA 0.5 6.26 0.32 1.17e-9 IgG glycosylation; LUSC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.44 -0.42 9.51e-16 Cystic fibrosis severity; LUSC cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg00071950 chr4:10020882 SLC2A9 0.62 10.5 0.5 1.8e-22 Bone mineral density; LUSC trans rs890100 0.673 rs10170366 chr2:56662366 A/G cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.75e-9 Gut microbiome composition (summer); LUSC trans rs61931739 0.513 rs10844698 chr12:33890158 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.8 0.35 4.74e-11 Morning vs. evening chronotype; LUSC cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.49 8.03 0.4 1.74e-14 IgG glycosylation; LUSC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg08439880 chr3:133502540 NA -0.33 -6.02 -0.31 4.66e-9 Iron status biomarkers; LUSC cis rs1559088 0.600 rs7246566 chr19:33589618 A/T cg27124370 chr19:33622961 WDR88 0.55 7.86 0.39 5.46e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg12386194 chr3:101231763 SENP7 0.53 7.36 0.37 1.45e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg18681998 chr4:17616180 MED28 0.83 14.53 0.62 2.08e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg23283495 chr1:209979779 IRF6 -0.61 -9.05 -0.44 1.17e-17 Cleft lip with or without cleft palate; LUSC trans rs11039798 0.764 rs11039929 chr11:48703289 A/G cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC trans rs4843747 0.671 rs72818577 chr16:88111181 G/A cg26811252 chr16:29126840 RRN3P2 0.59 9.32 0.45 1.63e-18 Menopause (age at onset); LUSC cis rs9311676 0.632 rs1126722 chr3:58413518 T/G cg26110898 chr3:58419937 PDHB 0.4 6.48 0.33 3.3e-10 Systemic lupus erythematosus; LUSC cis rs4474465 0.850 rs4245460 chr11:78258147 G/C cg27205649 chr11:78285834 NARS2 0.54 6.32 0.33 8.2e-10 Alzheimer's disease (survival time); LUSC cis rs7917772 0.560 rs4919664 chr10:104363408 A/C cg05855489 chr10:104503620 C10orf26 -0.48 -7.41 -0.38 1.04e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg22823121 chr1:150693482 HORMAD1 0.47 6.66 0.34 1.13e-10 Melanoma; LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18404041 chr3:52824283 ITIH1 -0.63 -12.4 -0.56 2.57e-29 Bipolar disorder; LUSC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg07157834 chr1:205819609 PM20D1 -0.43 -5.92 -0.31 7.8e-9 Parkinson's disease; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.96 0.77 8.44e-67 Prudent dietary pattern; LUSC cis rs941408 1.000 rs2260416 chr19:2796355 G/A cg06609049 chr19:2785107 THOP1 0.68 10.78 0.51 1.93e-23 Total cholesterol levels; LUSC cis rs7772486 0.806 rs4075695 chr6:146250959 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -8.2 -0.41 5.16e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303401 0.625 rs34963822 chr17:56988424 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.5 0.59 1.89e-33 Cognitive test performance; LUSC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.55 -8.13 -0.41 8.73e-15 Platelet count; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg11905131 chr22:24372483 LOC391322 -0.61 -10.45 -0.5 2.74e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg13722127 chr7:150037890 RARRES2 0.38 5.8 0.3 1.52e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.88 0.31 1.02e-8 Personality dimensions; LUSC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg03433033 chr1:76189801 ACADM -0.82 -13.07 -0.58 8.52e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg11645453 chr3:52864694 ITIH4 0.35 8.08 0.4 1.16e-14 Bipolar disorder; LUSC cis rs9329221 0.662 rs35472251 chr8:10246669 A/G cg21775007 chr8:11205619 TDH 0.44 5.78 0.3 1.7e-8 Neuroticism; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg11766577 chr21:47581405 C21orf56 0.47 7.09 0.36 8.02e-12 Testicular germ cell tumor; LUSC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg02782426 chr3:40428986 ENTPD3 0.39 7.46 0.38 7.62e-13 Renal cell carcinoma; LUSC cis rs6835098 1.000 rs10031414 chr4:174084953 A/C cg08422745 chr4:174089978 GALNT7 -0.84 -13.96 -0.61 3.19e-35 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.21 0.59 2.34e-32 Total body bone mineral density; LUSC cis rs10782582 0.609 rs2881785 chr1:76318096 T/C cg03433033 chr1:76189801 ACADM -0.44 -6.47 -0.33 3.5e-10 Daytime sleep phenotypes; LUSC cis rs2279817 0.955 rs2270977 chr1:18023509 T/C cg21791023 chr1:18019539 ARHGEF10L 0.46 6.43 0.33 4.39e-10 Neuroticism; LUSC cis rs7103648 1.000 rs11039225 chr11:47430599 G/A cg20307385 chr11:47447363 PSMC3 0.99 19.5 0.73 4.42e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg05868516 chr6:26286170 HIST1H4H 0.35 5.69 0.3 2.8e-8 Educational attainment; LUSC cis rs9788682 1.000 rs7181447 chr15:78814567 A/G cg18825076 chr15:78729989 IREB2 0.47 6.4 0.33 5.32e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.1e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg17063962 chr7:91808500 NA 0.58 9.34 0.46 1.35e-18 Breast cancer; LUSC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg14019146 chr3:50243930 SLC38A3 0.31 6.78 0.35 5.6e-11 Intelligence (multi-trait analysis); LUSC cis rs870825 0.929 rs55635512 chr4:185589982 G/T cg04058563 chr4:185651563 MLF1IP 0.81 10.77 0.51 2e-23 Blood protein levels; LUSC cis rs790123 1.000 rs2650950 chr3:122382048 C/T cg00926285 chr3:122398533 PARP14 -0.38 -5.87 -0.31 1.06e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg03433033 chr1:76189801 ACADM 0.84 15.34 0.64 1.48e-40 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs7819412 0.527 rs7821914 chr8:10805015 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -7.01 -0.36 1.3e-11 Triglycerides; LUSC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg10664184 chr19:17420304 DDA1 0.46 5.7 0.3 2.6e-8 Systemic lupus erythematosus; LUSC trans rs11098499 1.000 rs35643470 chr4:120184948 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.09 0.32 3.14e-9 Corneal astigmatism; LUSC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg26850624 chr5:429559 AHRR -0.39 -7.72 -0.39 1.4e-13 Cystic fibrosis severity; LUSC trans rs853679 0.607 rs36101351 chr6:27943369 C/T cg01620082 chr3:125678407 NA -0.8 -7.24 -0.37 3.11e-12 Depression; LUSC cis rs35883536 0.609 rs1577513 chr1:101044402 C/A cg06223162 chr1:101003688 GPR88 0.5 9.38 0.46 1.03e-18 Monocyte count; LUSC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg08847533 chr14:75593920 NEK9 0.64 10.55 0.5 1.17e-22 Coronary artery disease; LUSC cis rs76878669 0.515 rs947978 chr11:66108660 C/T cg18002602 chr11:66138449 SLC29A2 0.47 8.52 0.42 5.65e-16 Educational attainment (years of education); LUSC cis rs694739 0.536 rs671976 chr11:64046029 G/A cg05555928 chr11:63887634 MACROD1 -0.35 -6.7 -0.34 9.06e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs2587949 0.571 rs2322589 chr3:4229371 G/C cg15139668 chr4:4577005 NA -0.42 -6.12 -0.32 2.63e-9 Periodontitis (DPAL); LUSC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs853679 0.517 rs4713135 chr6:28039586 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.18 -0.32 1.9e-9 Depression; LUSC cis rs11676348 0.818 rs6436033 chr2:218983763 A/G cg06547715 chr2:218990976 CXCR2 0.33 6.37 0.33 6.09e-10 Ulcerative colitis; LUSC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg04025307 chr7:1156635 C7orf50 0.42 5.89 0.31 9.54e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs9325144 0.647 rs1875609 chr12:39018259 C/T cg13010199 chr12:38710504 ALG10B -0.52 -7.93 -0.4 3.42e-14 Morning vs. evening chronotype; LUSC cis rs950169 0.800 rs4099846 chr15:84956894 C/G cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.64e-15 Schizophrenia; LUSC cis rs4363385 0.510 rs6673356 chr1:153041903 C/T cg25856811 chr1:152973957 SPRR3 0.36 6.07 0.32 3.56e-9 Inflammatory skin disease; LUSC cis rs56399783 0.901 rs757788 chr7:2836433 A/G cg19731401 chr7:2775893 GNA12 0.68 9.01 0.44 1.64e-17 Childhood ear infection; LUSC cis rs9303401 0.614 rs34843288 chr17:57103140 T/C cg25039879 chr17:56429692 SUPT4H1 0.72 9.25 0.45 2.82e-18 Cognitive test performance; LUSC cis rs61931739 0.500 rs9919726 chr12:34510783 A/G cg06521331 chr12:34319734 NA -0.41 -6.8 -0.35 4.96e-11 Morning vs. evening chronotype; LUSC cis rs6977660 1.000 rs7791038 chr7:19798833 G/A cg07541023 chr7:19748670 TWISTNB 0.58 6.55 0.34 2.16e-10 Thyroid stimulating hormone; LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg01879757 chr17:41196368 BRCA1 -0.46 -7.13 -0.36 6.39e-12 Menopause (age at onset); LUSC cis rs7582180 0.629 rs11685250 chr2:100955137 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.64 -0.43 2.36e-16 Intelligence (multi-trait analysis); LUSC cis rs7819412 0.875 rs6981523 chr8:11061792 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.8 -0.3 1.51e-8 Triglycerides; LUSC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg00255919 chr5:131827918 IRF1 -0.4 -7.61 -0.38 2.89e-13 Asthma (sex interaction); LUSC cis rs4253772 0.678 rs9627281 chr22:46644168 A/G cg09491104 chr22:46646882 C22orf40 -0.6 -8.59 -0.43 3.3e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs6138458 0.717 rs2179732 chr20:25000446 A/T cg06937882 chr20:24974362 C20orf3 -0.31 -5.66 -0.3 3.2e-8 Blood protein levels; LUSC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg13319975 chr6:146136371 FBXO30 0.72 11.13 0.52 1.11e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.12 0.32 2.64e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12286929 0.687 rs6589487 chr11:115089927 T/C cg04055981 chr11:115044050 NA -0.36 -6.31 -0.33 8.72e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg08508325 chr11:3079039 CARS -0.51 -12.75 -0.57 1.32e-30 Longevity; LUSC cis rs4888262 0.545 rs4243108 chr16:74692453 A/G cg01733217 chr16:74700730 RFWD3 -0.77 -12.62 -0.57 4.14e-30 Testicular germ cell tumor; LUSC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg20503657 chr10:835505 NA 0.82 11.71 0.54 8.84e-27 Eosinophil percentage of granulocytes; LUSC cis rs6456156 0.586 rs2001114 chr6:167486578 A/G cg25258033 chr6:167368657 RNASET2 0.4 6.02 0.31 4.59e-9 Primary biliary cholangitis; LUSC cis rs290268 0.817 rs291006 chr9:93540244 A/C cg02608019 chr9:93564028 SYK 0.46 7.36 0.37 1.41e-12 Platelet count; LUSC cis rs7296418 0.961 rs1790121 chr12:123604492 G/A cg06742321 chr12:123595122 PITPNM2 0.39 5.74 0.3 2.17e-8 Platelet count; LUSC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg06238570 chr21:40685208 BRWD1 -0.64 -10.71 -0.51 3.2e-23 Cognitive function; LUSC trans rs7937682 0.575 rs12808601 chr11:111776066 G/A cg18187862 chr3:45730750 SACM1L -0.55 -6.98 -0.36 1.6e-11 Primary sclerosing cholangitis; LUSC cis rs11608355 0.810 rs12424599 chr12:109866615 A/G cg05360138 chr12:110035743 NA 0.58 7.44 0.38 8.34e-13 Neuroticism; LUSC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg00484396 chr16:3507460 NAT15 -0.71 -12.59 -0.57 5.03e-30 Tuberculosis; LUSC cis rs9653442 0.545 rs11681966 chr2:100759457 A/C cg22139774 chr2:100720529 AFF3 0.41 6.91 0.35 2.51e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9677476 0.779 rs7569597 chr2:232102754 G/A cg07929768 chr2:232055508 NA 0.36 6.14 0.32 2.28e-9 Food antigen IgG levels; LUSC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg00310523 chr12:86230176 RASSF9 -0.44 -8.28 -0.41 3.05e-15 Major depressive disorder; LUSC trans rs6951245 0.554 rs58210047 chr7:1149381 G/A cg13565492 chr6:43139072 SRF -0.71 -10.51 -0.5 1.6e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs66887589 0.934 rs7672519 chr4:120544112 C/T cg24375607 chr4:120327624 NA -0.47 -7.24 -0.37 3.09e-12 Diastolic blood pressure; LUSC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg11764359 chr7:65958608 NA 0.62 9.4 0.46 8.7e-19 Aortic root size; LUSC cis rs2439831 0.850 rs16965120 chr15:44100342 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.69 6.34 0.33 7.66e-10 Lung cancer in ever smokers; LUSC cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg05985134 chr18:33552581 C18orf21 0.51 6.9 0.35 2.7e-11 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs11088226 1.000 rs2833888 chr21:33927560 A/G cg09050820 chr6:167586206 TCP10L2 0.56 7.33 0.37 1.71e-12 Gastritis; LUSC trans rs970548 0.697 rs11239540 chr10:45999209 T/C cg14222797 chr10:16859974 RSU1 -0.6 -5.96 -0.31 6.36e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC trans rs1994135 0.669 rs2121831 chr12:33697674 G/A cg13010199 chr12:38710504 ALG10B 0.54 7.45 0.38 7.8e-13 Resting heart rate; LUSC cis rs35264875 0.796 rs72928657 chr11:68852336 T/C cg02660097 chr11:68866761 NA 0.43 6.07 0.32 3.44e-9 Blond vs. brown hair color; LUSC trans rs4948088 1.000 rs7776597 chr7:51015582 A/G cg26816907 chr1:197890812 LHX9 0.58 6.46 0.33 3.72e-10 Type 1 diabetes; LUSC cis rs1150668 0.796 rs213237 chr6:28323938 T/C cg21251018 chr6:28226885 NKAPL 0.34 6.42 0.33 4.73e-10 Pubertal anthropometrics; LUSC cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg05294307 chr14:35346193 BAZ1A -0.61 -7.4 -0.38 1.15e-12 Psoriasis; LUSC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg08798685 chr6:27730294 NA -0.68 -6.05 -0.31 3.97e-9 Depression; LUSC cis rs829883 0.934 rs249814 chr12:98892964 A/G cg25150519 chr12:98850993 NA 0.64 9.72 0.47 7.74e-20 Colorectal adenoma (advanced); LUSC cis rs931127 0.547 rs3886859 chr11:65458310 C/T cg05805236 chr11:65401703 PCNXL3 -0.42 -7.3 -0.37 2.13e-12 Systemic lupus erythematosus; LUSC cis rs2219968 0.923 rs2101106 chr8:78948481 A/C cg00738934 chr8:78996279 NA 0.37 6.57 0.34 1.93e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs472402 0.623 rs8192130 chr5:6636450 G/A cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.53 -7.91 -0.4 3.89e-14 Response to amphetamines; LUSC trans rs1994135 0.617 rs10844642 chr12:33730368 A/C cg26384229 chr12:38710491 ALG10B 0.67 9.4 0.46 8.99e-19 Resting heart rate; LUSC cis rs4664304 0.900 rs3828327 chr2:160742095 G/A cg23995753 chr2:160760732 LY75 -0.33 -6.06 -0.31 3.61e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg06636001 chr8:8085503 FLJ10661 0.6 9.57 0.46 2.41e-19 Mood instability; LUSC cis rs2219968 0.961 rs12056471 chr8:78962821 T/C cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7246967 0.673 rs55744741 chr19:22959973 C/T cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg18132916 chr6:79620363 NA -0.38 -5.74 -0.3 2.18e-8 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.739 rs9450318 chr6:86427177 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 10.55 0.5 1.24e-22 Response to antipsychotic treatment; LUSC cis rs73198271 0.603 rs777705 chr8:8586868 C/T cg01851573 chr8:8652454 MFHAS1 0.39 6.02 0.31 4.63e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg11812906 chr14:75593930 NEK9 -0.53 -8.56 -0.42 4.33e-16 Coronary artery disease; LUSC trans rs2587949 0.593 rs1872416 chr3:4211269 G/T cg15139668 chr4:4577005 NA 0.41 6.08 0.32 3.23e-9 Periodontitis (DPAL); LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg10729496 chr3:10149963 C3orf24 -0.53 -6.63 -0.34 1.36e-10 Alzheimer's disease; LUSC trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg03929089 chr4:120376271 NA 0.68 7.54 0.38 4.38e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs9467711 0.659 rs35277236 chr6:26562269 G/T cg06606381 chr12:133084897 FBRSL1 -0.75 -6.68 -0.34 1.03e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg18765753 chr7:1198926 ZFAND2A -0.41 -7.65 -0.39 2.21e-13 Longevity;Endometriosis; LUSC trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7241530 0.610 rs7235552 chr18:75892776 T/G cg14642773 chr18:75888474 NA 0.37 5.65 0.3 3.53e-8 Educational attainment (years of education); LUSC cis rs757081 0.643 rs665311 chr11:17206740 A/T cg15432903 chr11:17409602 KCNJ11 -0.38 -5.85 -0.3 1.18e-8 Systolic blood pressure; LUSC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg14668632 chr7:2872130 GNA12 -0.45 -6.78 -0.35 5.42e-11 Height; LUSC trans rs3857536 0.813 rs2188589 chr6:66939570 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs7147624 1.000 rs4902408 chr14:66111901 A/T cg03016385 chr14:66212404 NA -0.78 -8.5 -0.42 6.58e-16 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg18721089 chr20:30220636 NA -0.36 -6.16 -0.32 2.14e-9 Mean corpuscular hemoglobin; LUSC cis rs2228479 0.541 rs9806913 chr16:89953773 A/G cg26513180 chr16:89883248 FANCA 0.61 5.84 0.3 1.22e-8 Skin colour saturation; LUSC cis rs11690935 0.959 rs10184866 chr2:172608956 T/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -15.29 -0.64 2.14e-40 Schizophrenia; LUSC trans rs2085496 0.764 rs1596751 chr2:193807860 A/G cg25750719 chr6:26033975 HIST1H2AB 0.37 6.07 0.32 3.52e-9 Neuroticism; LUSC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg18350739 chr11:68623251 NA -0.37 -6.69 -0.34 9.24e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs8073060 0.671 rs9894813 chr17:33873848 C/T cg19694781 chr19:47549865 TMEM160 0.84 12.6 0.57 4.67e-30 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg24562669 chr7:97807699 LMTK2 -0.35 -6.14 -0.32 2.38e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs988712 0.516 rs6484320 chr11:27703188 T/A cg10635145 chr11:27742435 BDNF 0.46 6.24 0.32 1.36e-9 Obesity; LUSC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg04850211 chr1:228464232 OBSCN -0.33 -6.17 -0.32 2.03e-9 Diastolic blood pressure; LUSC cis rs11148252 0.740 rs9526914 chr13:52976300 G/T cg00495681 chr13:53174319 NA 0.55 8.64 0.43 2.39e-16 Lewy body disease; LUSC cis rs11690935 0.550 rs6730085 chr2:172864845 C/A cg13550731 chr2:172543902 DYNC1I2 0.52 7.81 0.39 7.49e-14 Schizophrenia; LUSC cis rs713477 0.901 rs7146306 chr14:55905853 C/T cg04306507 chr14:55594613 LGALS3 -0.29 -5.65 -0.3 3.41e-8 Pediatric bone mineral content (femoral neck); LUSC cis rs7188861 0.768 rs181694 chr16:11384829 C/T cg00044050 chr16:11439710 C16orf75 0.56 6.42 0.33 4.64e-10 HDL cholesterol; LUSC cis rs2219968 0.717 rs4610733 chr8:78914112 T/G cg00738934 chr8:78996279 NA -0.4 -7.18 -0.37 4.55e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11890956 chr21:40555474 PSMG1 1.03 20.36 0.74 1.73e-60 Cognitive function; LUSC trans rs7939886 0.920 rs17149859 chr11:55795356 G/A cg15704280 chr7:45808275 SEPT13 0.79 6.74 0.35 7.14e-11 Myopia (pathological); LUSC cis rs1979679 0.608 rs3803087 chr12:28726634 T/C cg13890972 chr12:28721907 NA -0.43 -6.24 -0.32 1.31e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg04369109 chr6:150039330 LATS1 -0.58 -8.57 -0.42 4e-16 Lung cancer; LUSC cis rs977987 0.806 rs4888388 chr16:75394148 G/A cg03315344 chr16:75512273 CHST6 0.48 9.2 0.45 4.05e-18 Dupuytren's disease; LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.16 0.36 5.02e-12 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04611479 chr17:41910366 MPP3 -0.41 -6.06 -0.31 3.77e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg06138931 chr13:21896616 NA 0.39 6.62 0.34 1.43e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg17509989 chr5:176798049 RGS14 0.68 10.69 0.5 3.87e-23 Hemoglobin concentration;Hematocrit; LUSC cis rs7091068 0.518 rs913045 chr10:95431535 C/T cg20715218 chr10:95462985 C10orf4 0.46 5.88 0.31 1.01e-8 Urinary tract infection frequency; LUSC cis rs9398803 0.865 rs2152876 chr6:126761228 A/G cg19875578 chr6:126661172 C6orf173 -0.41 -6.09 -0.32 3.17e-9 Male-pattern baldness; LUSC trans rs62238980 0.614 rs79022443 chr22:32456717 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg17294928 chr15:75287854 SCAMP5 0.4 5.65 0.3 3.47e-8 Breast cancer; LUSC cis rs240764 0.817 rs239242 chr6:101092776 C/T cg09795085 chr6:101329169 ASCC3 0.41 5.99 0.31 5.54e-9 Neuroticism; LUSC cis rs1801251 1.000 rs6437074 chr2:233712296 C/T cg25237894 chr2:233734115 C2orf82 -0.35 -6.58 -0.34 1.84e-10 Coronary artery disease; LUSC trans rs7819412 0.668 rs2409715 chr8:11010136 A/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.19 -0.32 1.81e-9 Triglycerides; LUSC cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg15423357 chr2:25149977 NA 0.4 8.02 0.4 1.84e-14 Body mass index; LUSC cis rs7267979 0.789 rs6083810 chr20:25329759 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.77 -15.6 -0.65 1.39e-41 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6076065 1.000 rs2424547 chr20:23392690 A/G cg11657817 chr20:23433608 CST11 0.44 8.72 0.43 1.34e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg16680214 chr1:154839983 KCNN3 -0.52 -9.74 -0.47 6.53e-20 Prostate cancer; LUSC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg14784868 chr12:69753453 YEATS4 0.7 11.44 0.53 8.42e-26 Blood protein levels; LUSC cis rs2204008 0.623 rs1315348 chr12:38163044 G/A cg26384229 chr12:38710491 ALG10B -0.68 -10.51 -0.5 1.68e-22 Bladder cancer; LUSC cis rs977987 0.815 rs11861810 chr16:75461829 A/G cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg04414720 chr1:150670196 GOLPH3L -0.44 -6.91 -0.35 2.4e-11 Tonsillectomy; LUSC cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.83 -0.35 4.11e-11 Monocyte percentage of white cells; LUSC cis rs10197940 0.550 rs77233070 chr2:152416477 G/A cg06191203 chr2:152266755 RIF1 -0.54 -6.92 -0.35 2.26e-11 Lung cancer; LUSC cis rs240764 0.658 rs4839792 chr6:101253788 A/T cg09795085 chr6:101329169 ASCC3 -0.47 -6.71 -0.34 8.18e-11 Neuroticism; LUSC cis rs868036 0.681 rs1026737 chr15:68107072 A/C cg08079166 chr15:68083412 MAP2K5 0.41 7.23 0.37 3.29e-12 Restless legs syndrome; LUSC cis rs11252926 0.501 rs2050971 chr10:525530 T/G cg03684893 chr10:554711 DIP2C 0.4 7.42 0.38 9.74e-13 Psychosis in Alzheimer's disease; LUSC cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg04727924 chr7:799746 HEATR2 -0.51 -6.29 -0.33 9.83e-10 Cerebrospinal P-tau181p levels; LUSC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg04398451 chr17:18023971 MYO15A 0.51 8.17 0.41 6.29e-15 Total body bone mineral density; LUSC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg24733560 chr20:60626293 TAF4 0.43 7.87 0.4 4.88e-14 Body mass index; LUSC trans rs1218582 0.741 rs7544528 chr1:154844585 C/T cg05839875 chr5:39203190 FYB -0.31 -5.95 -0.31 6.92e-9 Prostate cancer; LUSC cis rs6906287 0.631 rs9320663 chr6:118986172 A/G cg21191810 chr6:118973309 C6orf204 0.32 6.05 0.31 3.83e-9 Electrocardiographic conduction measures; LUSC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg16325326 chr1:53192061 ZYG11B -0.88 -16.23 -0.66 4.26e-44 Monocyte count; LUSC cis rs7772486 0.776 rs4316025 chr6:146238032 C/T cg23711669 chr6:146136114 FBXO30 -0.81 -14.85 -0.63 1.16e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4595586 0.545 rs2218761 chr12:39393593 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg16262614 chr3:133464971 TF 0.43 7.51 0.38 5.41e-13 Iron status biomarkers (transferrin levels); LUSC cis rs7512552 0.646 rs1694367 chr1:150329469 T/A cg15654264 chr1:150340011 RPRD2 0.64 10.58 0.5 9.37e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs73198271 0.515 rs11780216 chr8:8625720 G/T cg01851573 chr8:8652454 MFHAS1 0.62 7.34 0.37 1.61e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.17 0.45 4.8e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.35e-22 Alzheimer's disease (late onset); LUSC cis rs6565180 0.963 rs4787642 chr16:30359408 T/C cg17640201 chr16:30407289 ZNF48 -0.85 -14.3 -0.62 1.56e-36 Tonsillectomy; LUSC trans rs11700980 0.551 rs2832028 chr21:30114431 T/C cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg12698349 chr2:225449008 CUL3 0.66 8.37 0.42 1.55e-15 IgE levels in asthmatics (D.p. specific); LUSC cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg23625390 chr15:77176239 SCAPER 0.53 8.42 0.42 1.09e-15 Blood metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22164287 chr1:178995540 FAM20B -0.41 -6.1 -0.32 2.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4474465 1.000 rs1567889 chr11:78147055 A/G cg27205649 chr11:78285834 NARS2 -0.54 -6.28 -0.32 1.08e-9 Alzheimer's disease (survival time); LUSC cis rs1348850 0.574 rs4893835 chr2:178442592 T/C cg27490568 chr2:178487706 NA 0.38 5.72 0.3 2.39e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9329221 0.686 rs35406700 chr8:10244593 A/G cg21775007 chr8:11205619 TDH 0.48 6.54 0.34 2.3e-10 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17181325 chr17:1613831 TLCD2 -0.51 -6.76 -0.35 6.09e-11 Bipolar disorder and schizophrenia; LUSC cis rs4242434 0.927 rs3736147 chr8:22471824 A/G cg03733263 chr8:22462867 KIAA1967 -0.98 -18.07 -0.7 2.09e-51 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg15839431 chr19:19639596 YJEFN3 0.66 7.17 0.37 4.73e-12 Bipolar disorder; LUSC cis rs2414856 0.510 rs76861340 chr15:64601854 T/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.62 -0.38 2.7e-13 Developmental language disorder (linguistic errors); LUSC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg00129232 chr17:37814104 STARD3 -0.4 -5.77 -0.3 1.85e-8 Asthma; LUSC cis rs7903847 0.642 rs6584127 chr10:99142948 A/C cg20016023 chr10:99160130 RRP12 -0.33 -8.06 -0.4 1.41e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs7914558 0.646 rs7909591 chr10:104659018 G/T cg05855489 chr10:104503620 C10orf26 0.42 5.76 0.3 1.92e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7192380 0.895 rs2917670 chr16:69758963 T/C cg26679644 chr16:69762563 NA -0.34 -5.66 -0.3 3.22e-8 Sjögren's syndrome; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.67 10.35 0.49 5.63e-22 Lymphocyte counts; LUSC trans rs4729127 1.000 rs17166212 chr7:94008385 A/G cg20086523 chr13:52378287 DHRS12 0.54 6.31 0.33 9.11e-10 Intelligence; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.69 0.34 9.34e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9473147 0.516 rs6931478 chr6:47461913 C/A cg20196966 chr6:47445060 CD2AP 0.42 5.81 0.3 1.49e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg15687855 chr3:44754131 ZNF502 -0.37 -5.94 -0.31 7.13e-9 Depressive symptoms; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.58 -9.25 -0.45 2.82e-18 Prudent dietary pattern; LUSC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.6e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs7829975 0.774 rs1039915 chr8:8679614 T/C cg21775007 chr8:11205619 TDH 0.43 6.13 0.32 2.46e-9 Mood instability; LUSC cis rs599083 0.829 rs314751 chr11:68179560 C/T cg01657329 chr11:68192670 LRP5 0.5 7.5 0.38 5.88e-13 Bone mineral density (spine); LUSC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg14583973 chr4:3374767 RGS12 0.38 8.2 0.41 5.06e-15 Serum sulfate level; LUSC cis rs56283067 0.578 rs12211510 chr6:45361189 A/G cg20913747 chr6:44695427 NA -0.44 -6.42 -0.33 4.68e-10 Total body bone mineral density; LUSC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg17330251 chr7:94953956 PON1 -0.37 -5.91 -0.31 8.61e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg06238570 chr21:40685208 BRWD1 0.5 7.51 0.38 5.57e-13 Cognitive function; LUSC cis rs9837602 1.000 rs71313585 chr3:99770696 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.26 0.32 1.18e-9 Breast cancer; LUSC cis rs1799949 0.965 rs8071278 chr17:41193910 A/T cg23758822 chr17:41437982 NA 1.01 18.64 0.71 1.21e-53 Menopause (age at onset); LUSC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg00944433 chr1:107599041 PRMT6 -0.38 -7.07 -0.36 9.07e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg14893161 chr1:205819251 PM20D1 -0.46 -7.02 -0.36 1.28e-11 Menarche (age at onset); LUSC cis rs2346177 0.554 rs36006825 chr2:46708945 G/T cg02822958 chr2:46747628 ATP6V1E2 0.47 8.3 0.41 2.68e-15 HDL cholesterol; LUSC cis rs61990749 0.597 rs1006039 chr14:78263196 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.65 -7.03 -0.36 1.19e-11 Fibroblast growth factor basic levels; LUSC trans rs2797160 0.967 rs926854 chr6:126021780 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.98 0.36 1.64e-11 Endometrial cancer; LUSC trans rs72674100 1.000 rs28368345 chr4:97991439 T/C cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg04287289 chr16:89883240 FANCA 0.79 13.83 0.6 1.08e-34 Vitiligo; LUSC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.2 0.49 1.94e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg04025307 chr7:1156635 C7orf50 0.44 6.87 0.35 3.21e-11 Longevity;Endometriosis; LUSC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.95 -0.36 1.87e-11 Intelligence (multi-trait analysis); LUSC cis rs950776 0.518 rs12594391 chr15:78816240 A/G cg06917634 chr15:78832804 PSMA4 0.83 14.99 0.63 3.39e-39 Sudden cardiac arrest; LUSC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg11764359 chr7:65958608 NA 0.63 9.47 0.46 5.1e-19 Aortic root size; LUSC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.75 -0.8 1.56e-77 Height; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg00024416 chr22:24240387 NA -0.34 -6.01 -0.31 4.96e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs35110281 0.782 rs9981790 chr21:45045052 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.58 0.46 2.23e-19 Mean corpuscular volume; LUSC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg09904177 chr6:26538194 HMGN4 0.42 6.16 0.32 2.04e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs12310956 0.532 rs11052920 chr12:33955891 T/G cg26384229 chr12:38710491 ALG10B 0.67 10.54 0.5 1.33e-22 Morning vs. evening chronotype; LUSC cis rs1453414 1 rs1453414 chr11:5829084 G/C cg05234568 chr11:5960015 NA -0.52 -5.85 -0.31 1.14e-8 Oral cavity and pharyngeal cancer;Oropharynx cancer; LUSC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.79 -10.87 -0.51 8.81e-24 Schizophrenia; LUSC cis rs75804782 0.641 rs72987328 chr2:239360097 C/T cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.36e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs5167 0.777 rs56784978 chr19:45499388 T/C cg13119609 chr19:45449297 APOC2 0.34 5.83 0.3 1.33e-8 Blood protein levels; LUSC trans rs637571 0.522 rs556643 chr11:65733289 C/T cg17712092 chr4:129076599 LARP1B 0.71 10.71 0.51 3.3e-23 Eosinophil percentage of white cells; LUSC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg15445000 chr17:37608096 MED1 0.39 6.7 0.34 9.12e-11 Glomerular filtration rate (creatinine); LUSC trans rs7474896 0.616 rs1985260 chr10:38434090 C/T cg17830980 chr10:43048298 ZNF37B -0.55 -6.39 -0.33 5.49e-10 Obesity (extreme); LUSC cis rs13082711 0.911 rs34098124 chr3:27451242 G/T cg02860705 chr3:27208620 NA 0.51 8.3 0.41 2.6e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.73 12.73 0.57 1.55e-30 Personality dimensions; LUSC cis rs868036 1.000 rs3784719 chr15:68098180 C/T cg08079166 chr15:68083412 MAP2K5 0.4 8.32 0.41 2.28e-15 Restless legs syndrome; LUSC cis rs7113850 0.541 rs7101719 chr11:24234947 T/C ch.11.24196551F chr11:24239977 NA 0.97 9.02 0.44 1.53e-17 Bone fracture in osteoporosis; LUSC cis rs2230307 0.536 rs834164 chr1:100603948 A/C cg24955406 chr1:100503596 HIAT1 -0.59 -6.18 -0.32 1.88e-9 Carotid intima media thickness; LUSC cis rs10927875 0.832 rs4661342 chr1:16160773 C/G cg22431228 chr1:16359049 CLCNKA 0.38 6.9 0.35 2.55e-11 Dilated cardiomyopathy; LUSC cis rs921968 0.643 rs645796 chr2:219389236 A/G cg02176678 chr2:219576539 TTLL4 0.63 11.63 0.54 1.76e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg08736216 chr1:53307985 ZYG11A -0.28 -5.76 -0.3 1.9e-8 Monocyte count; LUSC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg09021430 chr5:549028 NA -0.54 -7.23 -0.37 3.23e-12 Lung disease severity in cystic fibrosis; LUSC cis rs477692 0.663 rs491929 chr10:131368111 G/A cg11019008 chr10:131425282 MGMT 0.41 5.9 0.31 9.1e-9 Response to temozolomide; LUSC cis rs6964587 0.967 rs10231350 chr7:91808499 G/T cg17063962 chr7:91808500 NA 0.6 9.63 0.47 1.56e-19 Breast cancer; LUSC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg18758796 chr5:131593413 PDLIM4 0.43 7.43 0.38 9.2e-13 Breast cancer; LUSC cis rs11209002 0.567 rs2755269 chr1:67541065 T/C cg02640540 chr1:67518911 SLC35D1 0.62 8.53 0.42 5.27e-16 Crohn's disease; LUSC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.23 0.74 5.87e-60 Homoarginine levels; LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.56 0.46 2.71e-19 Bipolar disorder; LUSC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg08683831 chr4:1404607 NA 0.36 6.01 0.31 4.87e-9 Obesity-related traits; LUSC cis rs8016982 0.617 rs2241621 chr14:81737076 G/T cg01989461 chr14:81687754 GTF2A1 -0.63 -10.42 -0.5 3.49e-22 Schizophrenia; LUSC cis rs6733011 0.644 rs6542839 chr2:99464530 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.42 5.79 0.3 1.59e-8 Bipolar disorder; LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg17150465 chr8:144897558 SCRIB 0.45 6.2 0.32 1.66e-9 Thyroid stimulating hormone; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg24060327 chr5:131705240 SLC22A5 0.67 11.07 0.52 1.82e-24 Blood metabolite levels; LUSC cis rs9435341 0.826 rs17496332 chr1:107546375 C/T cg09367891 chr1:107599246 PRMT6 -0.47 -6.9 -0.35 2.64e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs4595586 0.545 rs12819186 chr12:39356912 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs709400 0.628 rs3783394 chr14:103858673 G/A cg12935359 chr14:103987150 CKB -0.55 -8.44 -0.42 9.86e-16 Body mass index; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg13047869 chr3:10149882 C3orf24 -0.6 -8.92 -0.44 3.18e-17 Alzheimer's disease; LUSC cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg04455712 chr21:45112962 RRP1B -0.45 -8.16 -0.41 6.89e-15 Mean corpuscular volume; LUSC cis rs865483 0.895 rs2522966 chr17:35816616 A/G cg06716730 chr17:35851459 DUSP14 -0.27 -6.07 -0.32 3.38e-9 Monocyte count; LUSC cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg21770322 chr7:97807741 LMTK2 -0.5 -8.23 -0.41 4.36e-15 Breast cancer; LUSC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg05283184 chr6:79620031 NA -0.58 -11.98 -0.55 9.08e-28 Intelligence (multi-trait analysis); LUSC cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg08807101 chr21:30365312 RNF160 -0.72 -12.81 -0.57 7.8e-31 Dental caries; LUSC trans rs1969363 0.509 rs8189633 chr12:38065155 C/G cg06521331 chr12:34319734 NA -0.39 -6.0 -0.31 5.25e-9 Morning vs. evening chronotype; LUSC cis rs155346 1.000 rs265144 chr5:139397155 A/G cg01090482 chr5:139365336 NRG2 -0.36 -6.05 -0.31 3.84e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs1322512 0.665 rs2800647 chr6:152931491 C/T cg27316956 chr6:152958899 SYNE1 -0.35 -5.85 -0.31 1.15e-8 Tonometry; LUSC cis rs1662342 1.000 rs1662342 chr18:3255301 G/A cg00760847 chr18:3262519 MYL12B -0.6 -5.82 -0.3 1.39e-8 QRS duration; LUSC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg11764359 chr7:65958608 NA -0.7 -10.7 -0.51 3.47e-23 Aortic root size; LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg03352830 chr11:487213 PTDSS2 0.62 7.85 0.39 5.52e-14 Body mass index; LUSC cis rs7647973 0.626 rs12715437 chr3:49751856 T/C cg13072238 chr3:49761600 GMPPB -0.65 -8.27 -0.41 3.11e-15 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03297593 chr15:48470205 MYEF2 0.39 6.06 0.31 3.71e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14442939 chr10:27389572 ANKRD26 0.77 9.47 0.46 5.25e-19 Breast cancer; LUSC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg12292205 chr6:26970375 C6orf41 0.51 8.57 0.42 3.88e-16 Schizophrenia; LUSC cis rs6696846 0.765 rs2836 chr1:205111761 G/T cg21643547 chr1:205240462 TMCC2 0.42 7.65 0.39 2.23e-13 Red blood cell count; LUSC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.59 12.03 0.55 6.02e-28 Monocyte percentage of white cells; LUSC cis rs9905704 0.881 rs302846 chr17:56687536 T/A cg12560992 chr17:57184187 TRIM37 0.61 8.78 0.43 8.42e-17 Testicular germ cell tumor; LUSC trans rs1015291 0.708 rs1565592 chr12:19997502 T/G cg01501474 chr7:55323552 NA -0.45 -5.97 -0.31 6.09e-9 Diastolic blood pressure; LUSC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg21963583 chr11:68658836 MRPL21 -0.56 -8.74 -0.43 1.16e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7605827 0.866 rs11678132 chr2:15533998 C/T cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg02951883 chr7:2050386 MAD1L1 -0.53 -9.58 -0.46 2.35e-19 Bipolar disorder and schizophrenia; LUSC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg07828024 chr6:149772892 ZC3H12D -0.37 -7.91 -0.4 3.84e-14 Dupuytren's disease; LUSC trans rs7829975 0.806 rs2428 chr8:8641145 C/T cg27411982 chr8:10470053 RP1L1 0.45 7.26 0.37 2.71e-12 Mood instability; LUSC cis rs5756813 0.754 rs4821706 chr22:38154690 A/G cg06521852 chr22:38141419 TRIOBP 0.44 6.57 0.34 1.92e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs12760731 0.641 rs10494513 chr1:178252377 C/G cg00404053 chr1:178313656 RASAL2 0.58 6.52 0.34 2.53e-10 Obesity-related traits; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg24491122 chr3:124774370 HEG1 0.4 6.21 0.32 1.55e-9 Schizophrenia; LUSC cis rs459571 0.876 rs2520095 chr9:136919568 A/G cg13789015 chr9:136890014 NCRNA00094 0.7 13.04 0.58 1.07e-31 Platelet distribution width; LUSC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg19920283 chr7:105172520 RINT1 0.61 6.43 0.33 4.54e-10 Bipolar disorder (body mass index interaction); LUSC cis rs7107174 0.786 rs4945269 chr11:78047077 A/G cg02023728 chr11:77925099 USP35 0.44 6.67 0.34 1.03e-10 Testicular germ cell tumor; LUSC cis rs847577 0.569 rs12674083 chr7:97696334 C/T cg21770322 chr7:97807741 LMTK2 0.53 9.45 0.46 6.18e-19 Breast cancer; LUSC cis rs12295403 0.691 rs12808592 chr11:18677315 G/A cg09887367 chr11:18690185 NA -0.34 -6.87 -0.35 3.13e-11 Ovarian reserve; LUSC cis rs17270561 0.583 rs6937800 chr6:25765943 A/G cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg24562669 chr7:97807699 LMTK2 0.37 6.41 0.33 4.87e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9902453 0.967 rs56326816 chr17:28492805 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.52 7.84 0.39 6.24e-14 Coffee consumption (cups per day); LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs62400317 0.859 rs10948226 chr6:45299174 G/C cg18551225 chr6:44695536 NA -0.44 -7.35 -0.37 1.54e-12 Total body bone mineral density; LUSC cis rs7760949 0.963 rs7453814 chr6:13918291 C/G cg27413430 chr6:13925136 RNF182 0.57 8.56 0.42 4.2e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs4499344 0.696 rs2868153 chr19:33099277 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.85 13.09 0.58 6.76e-32 Mean platelet volume; LUSC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg20821713 chr7:1055600 C7orf50 -0.49 -5.69 -0.3 2.72e-8 Bronchopulmonary dysplasia; LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.87 -0.31 1.07e-8 Platelet count; LUSC cis rs295140 0.566 rs295141 chr2:201163556 C/T cg04283868 chr2:201171347 SPATS2L 0.42 6.22 0.32 1.45e-9 QT interval; LUSC cis rs4631830 0.828 rs10763567 chr10:51538169 C/A cg20129853 chr10:51489980 NA 0.33 6.6 0.34 1.61e-10 Prostate-specific antigen levels; LUSC cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.1 0.32 2.9e-9 Rheumatoid arthritis; LUSC cis rs7917772 0.582 rs7907760 chr10:104345197 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg11764359 chr7:65958608 NA -0.7 -10.69 -0.5 3.88e-23 Aortic root size; LUSC cis rs9815354 0.767 rs73079350 chr3:41876310 C/T cg03022575 chr3:42003672 ULK4 0.85 8.86 0.44 4.85e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs459571 0.959 rs2520099 chr9:136918139 T/C cg13789015 chr9:136890014 NCRNA00094 0.66 12.25 0.56 9.34e-29 Platelet distribution width; LUSC cis rs10911232 0.507 rs4397624 chr1:183053131 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Hypertriglyceridemia; LUSC cis rs11264213 0.901 rs584873 chr1:36431806 C/A cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.33e-14 Schizophrenia; LUSC cis rs6967385 0.836 rs62451463 chr7:12359513 T/G cg06484146 chr7:12443880 VWDE 0.4 5.89 0.31 9.3e-9 Response to taxane treatment (placlitaxel); LUSC cis rs7246657 1.000 rs12709812 chr19:37794850 A/G cg23950597 chr19:37808831 NA 0.59 6.94 0.35 2.1e-11 Coronary artery calcification; LUSC cis rs7818345 1.000 rs4430112 chr8:19293365 G/A cg11303988 chr8:19266685 CSGALNACT1 0.37 7.15 0.36 5.62e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs9420 0.961 rs12807250 chr11:57600285 C/T cg23127183 chr11:57508653 C11orf31 -0.57 -8.77 -0.43 9.53e-17 Schizophrenia; LUSC cis rs7180079 1.000 rs2062249 chr15:64672159 C/A cg02848875 chr15:64387786 SNX1 0.44 5.68 0.3 2.88e-8 Monocyte count; LUSC cis rs2816316 0.887 rs2760522 chr1:192529414 C/G cg02586212 chr1:192544902 RGS1 0.31 5.71 0.3 2.56e-8 Celiac disease; LUSC cis rs2439831 0.867 rs8041132 chr15:43635136 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs3790645 1.000 rs282176 chr1:26898956 T/C cg17456097 chr1:26900765 RPS6KA1 0.44 6.7 0.34 8.73e-11 Glucose homeostasis traits; LUSC cis rs7592578 0.508 rs62180987 chr2:191267173 A/G cg10560079 chr2:191398806 TMEM194B -0.51 -6.59 -0.34 1.71e-10 Diastolic blood pressure; LUSC cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg03146154 chr1:46216737 IPP 0.56 8.36 0.42 1.77e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7845219 0.544 rs2123647 chr8:95931782 A/G cg16049864 chr8:95962084 TP53INP1 0.44 7.47 0.38 7.28e-13 Type 2 diabetes; LUSC cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg20848291 chr7:100343083 ZAN 0.39 6.14 0.32 2.33e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg05776053 chr2:74358815 NA 0.48 7.5 0.38 5.8e-13 Gestational age at birth (maternal effect); LUSC cis rs79349575 0.715 rs9894220 chr17:46989154 C/T cg16584676 chr17:46985605 UBE2Z 0.42 5.81 0.3 1.49e-8 Type 2 diabetes; LUSC cis rs7980687 0.627 rs1727325 chr12:123698332 G/C cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Height;Educational attainment;Head circumference (infant); LUSC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg21963583 chr11:68658836 MRPL21 0.55 8.57 0.42 3.94e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11997175 0.902 rs7009022 chr8:33700404 A/G ch.8.33884649F chr8:33765107 NA 0.42 6.55 0.34 2.2e-10 Body mass index; LUSC cis rs262150 0.625 rs117651953 chr7:158780563 G/A cg19418458 chr7:158789849 NA 0.48 6.01 0.31 4.75e-9 Facial morphology (factor 20); LUSC cis rs2573652 1.000 rs2727195 chr15:100513117 G/A cg09918751 chr15:100517450 ADAMTS17 -0.39 -7.17 -0.37 4.87e-12 Height; LUSC cis rs6469656 1.000 rs7843852 chr8:117676506 C/T cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs2439831 0.867 rs2447196 chr15:43893818 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.8 -8.8 -0.43 7.44e-17 Lung cancer in ever smokers; LUSC cis rs72634258 0.945 rs397349 chr1:8074872 A/C cg26816564 chr1:7831052 VAMP3 0.47 6.52 0.34 2.53e-10 Inflammatory bowel disease; LUSC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg16049864 chr8:95962084 TP53INP1 -0.43 -7.21 -0.37 3.66e-12 Type 2 diabetes; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.54 -8.99 -0.44 1.92e-17 Lymphocyte counts; LUSC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg08109568 chr15:31115862 NA -0.74 -11.09 -0.52 1.47e-24 Huntington's disease progression; LUSC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2073300 1.000 rs6106656 chr20:23444301 A/G cg09953122 chr20:23471693 CST8 -0.77 -6.62 -0.34 1.46e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg00343986 chr7:65444356 GUSB 0.47 7.07 0.36 9.11e-12 Aortic root size; LUSC cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.5 -0.33 2.99e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 13.81 0.6 1.2e-34 Platelet count; LUSC trans rs4674124 0.938 rs35956698 chr2:217756348 A/G cg18563886 chr10:135203102 PAOX -0.44 -6.07 -0.32 3.56e-9 Breast cancer; LUSC cis rs977987 0.843 rs62062564 chr16:75442622 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.04 -0.36 1.09e-11 Dupuytren's disease; LUSC cis rs4786125 0.665 rs7201025 chr16:6920592 C/T cg03623568 chr16:6915990 A2BP1 -0.5 -8.3 -0.41 2.7e-15 Heart rate variability traits (SDNN); LUSC cis rs2742234 1.000 rs1864395 chr10:43655697 G/A cg15436174 chr10:43711423 RASGEF1A -0.37 -6.75 -0.35 6.38e-11 Hirschsprung disease; LUSC cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs1865760 1.000 rs56118523 chr6:25908975 A/G cg16482183 chr6:26056742 HIST1H1C 0.44 6.59 0.34 1.72e-10 Height; LUSC cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs12368653 0.666 rs701007 chr12:58113416 C/A cg12615879 chr12:58013172 SLC26A10 0.36 8.08 0.4 1.17e-14 Multiple sclerosis; LUSC cis rs950881 0.932 rs72823635 chr2:102931612 T/C cg20060108 chr2:102954350 IL1RL1 0.48 6.36 0.33 6.7e-10 Allergy; LUSC cis rs2625529 0.730 rs4777485 chr15:72389384 G/C cg16672083 chr15:72433130 SENP8 -0.51 -8.14 -0.41 8.07e-15 Red blood cell count; LUSC cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg19077165 chr18:44547161 KATNAL2 -0.42 -6.33 -0.33 7.76e-10 Personality dimensions; LUSC cis rs9733 0.650 rs61820165 chr1:150555987 C/T cg04414720 chr1:150670196 GOLPH3L -0.41 -6.27 -0.32 1.14e-9 Tonsillectomy; LUSC cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg24642439 chr20:33292090 TP53INP2 0.75 11.95 0.55 1.18e-27 Coronary artery disease; LUSC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg22907277 chr7:1156413 C7orf50 0.7 10.2 0.49 1.87e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs1670533 1.000 rs629261 chr4:1086763 A/C cg02018176 chr4:1364513 KIAA1530 0.46 6.45 0.33 3.83e-10 Recombination rate (females); LUSC cis rs7267979 1.000 rs4815405 chr20:25317492 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.57 -0.34 1.92e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7674212 0.539 rs6815783 chr4:104122146 A/C cg16532752 chr4:104119610 CENPE -0.47 -6.8 -0.35 4.81e-11 Type 2 diabetes; LUSC cis rs3859192 0.557 rs12602514 chr17:38159745 A/G cg17467752 chr17:38218738 THRA -0.51 -7.11 -0.36 6.9e-12 White blood cell count; LUSC cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg27129171 chr3:47204927 SETD2 0.7 11.72 0.54 8.25e-27 Colorectal cancer; LUSC cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 2e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.65 0.34 1.21e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg14416269 chr4:6271139 WFS1 0.49 10.35 0.49 5.91e-22 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7945718 0.967 rs1440286 chr11:12809152 G/A cg25843174 chr11:12811716 TEAD1 0.34 7.59 0.38 3.31e-13 Educational attainment (years of education); LUSC cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg02175503 chr12:58329896 NA -0.65 -10.81 -0.51 1.47e-23 Intelligence (multi-trait analysis); LUSC trans rs12478296 0.591 rs7573042 chr2:242996589 A/G cg01596870 chr19:55963115 NA -0.54 -7.42 -0.38 9.91e-13 Obesity-related traits; LUSC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg04287289 chr16:89883240 FANCA 0.77 6.23 0.32 1.42e-9 Skin colour saturation; LUSC cis rs12579753 0.917 rs7972839 chr12:82178920 C/T cg07988820 chr12:82153109 PPFIA2 -0.4 -5.76 -0.3 1.96e-8 Resting heart rate; LUSC cis rs1371867 0.846 rs1660347 chr8:101314980 G/A cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.81e-13 Atrioventricular conduction; LUSC cis rs7954584 0.567 rs11043246 chr12:122368944 G/A cg21016266 chr12:122356598 WDR66 0.61 9.13 0.45 6.9e-18 Mean corpuscular volume; LUSC trans rs2262909 0.925 rs73019838 chr19:22247732 T/A cg17074339 chr11:11642133 GALNTL4 0.47 7.17 0.37 4.92e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg21433313 chr16:3507492 NAT15 0.42 5.9 0.31 8.78e-9 Body mass index (adult); LUSC cis rs1008375 1.000 rs2872958 chr4:17665032 A/G cg15017067 chr4:17643749 FAM184B 0.35 5.76 0.3 1.95e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7945705 0.846 rs11042055 chr11:8756856 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.52 9.69 0.47 9.67e-20 Hemoglobin concentration; LUSC cis rs34779708 0.931 rs11010101 chr10:35411045 T/A cg04310649 chr10:35416472 CREM -0.43 -6.86 -0.35 3.34e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg16850897 chr7:100343110 ZAN -0.55 -7.97 -0.4 2.59e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg26120584 chr12:50795366 LARP4 0.35 5.99 0.31 5.55e-9 Triglycerides; LUSC cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.86 -11.29 -0.53 2.99e-25 Chronic sinus infection; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg14196790 chr5:131705035 SLC22A5 0.42 7.12 0.36 6.49e-12 Blood metabolite levels; LUSC cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg07636037 chr3:49044803 WDR6 -0.68 -8.84 -0.44 5.66e-17 Menarche (age at onset); LUSC cis rs7914558 0.505 rs12260436 chr10:104741114 A/C cg08650961 chr10:104748594 CNNM2 0.28 5.93 0.31 7.4e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs870825 0.929 rs55880126 chr4:185591237 T/G cg04058563 chr4:185651563 MLF1IP 0.9 12.21 0.56 1.33e-28 Blood protein levels; LUSC trans rs2204008 0.744 rs11168870 chr12:37973333 A/G cg06521331 chr12:34319734 NA -0.39 -5.98 -0.31 5.82e-9 Bladder cancer; LUSC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg22029157 chr1:209979665 IRF6 0.79 9.22 0.45 3.43e-18 Cleft lip with or without cleft palate; LUSC trans rs208520 0.690 rs4618506 chr6:66756889 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -16.13 -0.66 1.07e-43 Exhaled nitric oxide output; LUSC cis rs4077515 0.839 rs10781518 chr9:139300547 C/T cg14019695 chr9:139328340 INPP5E -0.42 -7.53 -0.38 4.93e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs477692 0.673 rs511361 chr10:131365052 C/T cg05714579 chr10:131428358 MGMT 0.46 6.34 0.33 7.43e-10 Response to temozolomide; LUSC cis rs17818399 0.890 rs34544165 chr2:46836906 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.46 -6.27 -0.32 1.08e-9 Height; LUSC trans rs2204008 0.745 rs8189516 chr12:38239084 C/T cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.8e-9 Bladder cancer; LUSC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg27398817 chr8:82754497 SNX16 0.61 7.65 0.39 2.16e-13 Diastolic blood pressure; LUSC cis rs2573652 1.000 rs2573650 chr15:100514097 A/G cg09918751 chr15:100517450 ADAMTS17 0.38 6.86 0.35 3.44e-11 Height; LUSC cis rs1144713 0.531 rs1716941 chr12:32255094 A/G cg01321189 chr12:32259338 BICD1 0.47 6.51 0.34 2.77e-10 Obesity-related traits; LUSC cis rs4474465 0.920 rs7113559 chr11:78205703 T/G cg27205649 chr11:78285834 NARS2 0.52 6.11 0.32 2.73e-9 Alzheimer's disease (survival time); LUSC cis rs4786125 0.555 rs7196838 chr16:6920457 A/G cg03623568 chr16:6915990 A2BP1 -0.45 -7.54 -0.38 4.59e-13 Heart rate variability traits (SDNN); LUSC cis rs911555 0.723 rs7149767 chr14:103863545 G/A cg12935359 chr14:103987150 CKB 0.65 10.5 0.5 1.85e-22 Intelligence (multi-trait analysis); LUSC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg04398451 chr17:18023971 MYO15A 0.57 9.53 0.46 3.41e-19 Total body bone mineral density; LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg16482183 chr6:26056742 HIST1H1C 0.54 8.09 0.4 1.12e-14 Height; LUSC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.863 rs28718422 chr4:120466304 C/A cg25214090 chr10:38739885 LOC399744 0.54 7.98 0.4 2.39e-14 Corneal astigmatism; LUSC cis rs2290159 0.948 rs5746255 chr3:12624321 A/G cg23032965 chr3:12705835 RAF1 0.51 6.92 0.35 2.36e-11 Cholesterol, total; LUSC cis rs710216 0.536 rs710222 chr1:43413653 A/G cg03128534 chr1:43423976 SLC2A1 0.61 10.58 0.5 9.51e-23 Red cell distribution width; LUSC cis rs67981189 0.613 rs221892 chr14:71611606 C/A cg15816911 chr14:71606274 NA -0.35 -6.19 -0.32 1.72e-9 Schizophrenia; LUSC cis rs12681288 0.754 rs4735975 chr8:1000470 T/C cg15309053 chr8:964076 NA 0.33 6.86 0.35 3.33e-11 Schizophrenia; LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg20887711 chr4:1340912 KIAA1530 0.45 6.68 0.34 9.71e-11 Obesity-related traits; LUSC trans rs7939886 0.920 rs11227212 chr11:55873334 A/G cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg25767906 chr1:53392781 SCP2 -0.62 -12.01 -0.55 7.07e-28 Monocyte count; LUSC cis rs7666738 0.546 rs13105521 chr4:98734419 C/T cg17366294 chr4:99064904 C4orf37 0.55 8.62 0.43 2.63e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs2835872 0.965 rs1515050 chr21:39003142 T/C cg20424643 chr21:39039972 KCNJ6 -0.42 -6.36 -0.33 6.7e-10 Electroencephalographic traits in alcoholism; LUSC cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg05535760 chr7:792225 HEATR2 0.8 9.58 0.46 2.37e-19 Cerebrospinal P-tau181p levels; LUSC cis rs7829975 0.774 rs11775523 chr8:8679176 A/G cg08975724 chr8:8085496 FLJ10661 0.52 7.7 0.39 1.53e-13 Mood instability; LUSC cis rs9807841 0.538 rs892086 chr19:10837677 C/T cg17710535 chr19:10819994 QTRT1 0.36 5.85 0.3 1.16e-8 Inflammatory skin disease; LUSC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.37 -0.33 6.22e-10 Height; LUSC cis rs10761482 0.500 rs1938524 chr10:62303573 T/A cg18175470 chr10:62150864 ANK3 -0.47 -6.96 -0.36 1.84e-11 Schizophrenia; LUSC cis rs911119 0.955 rs12625716 chr20:23606845 A/G cg16589663 chr20:23618590 CST3 -0.61 -7.23 -0.37 3.4e-12 Chronic kidney disease; LUSC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg25258033 chr6:167368657 RNASET2 0.47 7.99 0.4 2.21e-14 Crohn's disease; LUSC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -8.59 -0.43 3.46e-16 Schizophrenia; LUSC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg05084668 chr3:125655381 ALG1L -0.49 -7.01 -0.36 1.33e-11 Blood pressure (smoking interaction); LUSC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg18230493 chr5:56204884 C5orf35 -0.78 -12.28 -0.56 7.36e-29 Initial pursuit acceleration; LUSC cis rs600231 0.708 rs1784860 chr11:65240712 C/A cg21890820 chr11:65308645 LTBP3 0.49 7.16 0.36 5.14e-12 Bone mineral density; LUSC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg14092988 chr3:52407081 DNAH1 -0.36 -6.94 -0.36 2.02e-11 Bipolar disorder; LUSC trans rs6601327 0.504 rs2048655 chr8:9645562 G/T cg15556689 chr8:8085844 FLJ10661 0.44 6.03 0.31 4.27e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg09035930 chr12:129282057 SLC15A4 0.74 16.34 0.67 1.65e-44 Systemic lupus erythematosus; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -7.77 -0.39 9.74e-14 Longevity;Endometriosis; LUSC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg26554054 chr8:600488 NA 0.53 5.76 0.3 1.93e-8 IgG glycosylation; LUSC cis rs11785400 0.793 rs9297969 chr8:143723237 A/G cg24634471 chr8:143751801 JRK 0.51 7.21 0.37 3.71e-12 Schizophrenia; LUSC cis rs524023 0.874 rs506338 chr11:64440920 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.56 -0.5 1.11e-22 Urate levels in obese individuals; LUSC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg09359103 chr1:154839909 KCNN3 -0.7 -16.12 -0.66 1.23e-43 Prostate cancer; LUSC cis rs6977660 0.882 rs7781975 chr7:19849629 A/G cg05791153 chr7:19748676 TWISTNB 0.55 6.21 0.32 1.58e-9 Thyroid stimulating hormone; LUSC cis rs208520 1.000 rs208523 chr6:66954195 G/C cg07460842 chr6:66804631 NA -0.96 -12.45 -0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.94 0.35 2.1e-11 Rheumatoid arthritis; LUSC cis rs4595586 0.545 rs12813151 chr12:39363405 C/G cg26384229 chr12:38710491 ALG10B -0.5 -7.23 -0.37 3.3e-12 Morning vs. evening chronotype; LUSC cis rs751728 0.664 rs747694 chr6:33736490 A/G cg25922239 chr6:33757077 LEMD2 0.43 6.37 0.33 6.28e-10 Crohn's disease; LUSC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg24578937 chr1:2090814 PRKCZ 0.46 10.44 0.5 2.8e-22 Height; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg11102611 chr3:182971663 MCF2L2;B3GNT5 0.47 6.33 0.33 7.85e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1348850 0.645 rs11887886 chr2:178425730 C/T cg23306229 chr2:178417860 TTC30B 0.6 6.97 0.36 1.74e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9818758 0.607 rs34326553 chr3:49134429 A/G cg00383909 chr3:49044727 WDR6 1.21 9.66 0.47 1.21e-19 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg09359103 chr1:154839909 KCNN3 -0.69 -15.34 -0.64 1.47e-40 Prostate cancer; LUSC cis rs8092503 1.000 rs35413162 chr18:52498290 C/G cg12377874 chr18:52495404 RAB27B 0.33 5.71 0.3 2.49e-8 Childhood body mass index; LUSC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg23158103 chr7:148848205 ZNF398 -0.41 -6.56 -0.34 2.09e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10465746 0.967 rs28445286 chr1:84430483 A/G cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.01e-9 Obesity-related traits; LUSC cis rs793571 0.590 rs474875 chr15:59086703 A/C cg05156742 chr15:59063176 FAM63B 0.58 8.84 0.44 5.65e-17 Schizophrenia; LUSC cis rs6840360 0.837 rs4696294 chr4:152713089 C/A cg22705602 chr4:152727874 NA 0.29 6.28 0.33 1.04e-9 Intelligence (multi-trait analysis); LUSC cis rs7113850 0.541 rs7933381 chr11:24237534 T/C ch.11.24196551F chr11:24239977 NA 1.0 9.1 0.45 8.45e-18 Bone fracture in osteoporosis; LUSC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg04369109 chr6:150039330 LATS1 -0.55 -8.2 -0.41 5.09e-15 Lung cancer; LUSC cis rs10992471 0.756 rs10992319 chr9:95127895 G/A cg14631576 chr9:95140430 CENPP -0.34 -6.03 -0.31 4.38e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg06636001 chr8:8085503 FLJ10661 0.71 12.32 0.56 5.43e-29 Mood instability; LUSC cis rs6542838 0.698 rs6732017 chr2:99434381 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.51 -6.74 -0.35 7.13e-11 Fear of minor pain; LUSC cis rs35150201 0.557 rs10258155 chr7:135345319 A/G cg23117316 chr7:135346802 PL-5283 0.36 7.29 0.37 2.25e-12 Plateletcrit;Mean corpuscular hemoglobin;Mean platelet volume; LUSC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg22903471 chr2:27725779 GCKR -0.4 -6.84 -0.35 3.67e-11 Total body bone mineral density; LUSC cis rs9788682 1.000 rs7164594 chr15:78803057 C/T cg06917634 chr15:78832804 PSMA4 -0.56 -7.11 -0.36 6.93e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs17685 0.672 rs1639618 chr7:75701987 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.7 -0.39 1.58e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.35 0.33 6.88e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg00033643 chr7:134001901 SLC35B4 0.45 6.82 0.35 4.23e-11 Mean platelet volume; LUSC cis rs9814567 0.896 rs7653880 chr3:134345788 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -5.77 -0.3 1.84e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg18758796 chr5:131593413 PDLIM4 -0.39 -6.18 -0.32 1.89e-9 Breast cancer; LUSC cis rs2280018 0.609 rs2941253 chr16:15173746 G/A cg07549590 chr16:15018862 NA -0.46 -7.69 -0.39 1.63e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs11190604 0.652 rs76629555 chr10:102191417 T/C cg07080220 chr10:102295463 HIF1AN 0.61 8.15 0.41 7.63e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg03354898 chr7:1950403 MAD1L1 -0.32 -6.3 -0.33 9.32e-10 Bipolar disorder and schizophrenia; LUSC trans rs3806843 0.966 rs2563263 chr5:140137644 A/G cg25815440 chr2:42134162 NA -0.27 -5.95 -0.31 6.65e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg08704250 chr15:31115839 NA -0.59 -9.2 -0.45 3.95e-18 Huntington's disease progression; LUSC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.01 0.36 1.32e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg17076397 chr5:10353763 MARCH6 0.36 6.44 0.33 4.27e-10 Schizophrenia (age at onset); LUSC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg02269571 chr22:50332266 NA 0.37 5.89 0.31 9.28e-9 Schizophrenia; LUSC trans rs2727020 0.576 rs1814175 chr11:49559172 T/C cg15704280 chr7:45808275 SEPT13 -1.06 -20.14 -0.74 1.34e-59 Coronary artery disease; LUSC cis rs35264875 1.000 rs72928636 chr11:68848386 C/T cg02660097 chr11:68866761 NA 0.43 6.1 0.32 2.9e-9 Blond vs. brown hair color; LUSC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg23625390 chr15:77176239 SCAPER 0.46 7.02 0.36 1.25e-11 Blood metabolite levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg27049318 chr5:68514098 MRPS36 0.47 6.65 0.34 1.23e-10 Triglycerides; LUSC cis rs4268898 0.516 rs7597149 chr2:24371962 C/T cg06627628 chr2:24431161 ITSN2 0.51 7.27 0.37 2.53e-12 Asthma; LUSC cis rs3741151 1.000 rs3741149 chr11:73021084 A/G cg17517138 chr11:73019481 ARHGEF17 -0.9 -8.37 -0.42 1.57e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21842301 chr20:31989203 CDK5RAP1 -0.42 -6.14 -0.32 2.28e-9 Electrocardiographic conduction measures; LUSC cis rs6489882 0.867 rs4766664 chr12:113362997 T/G cg20102336 chr12:113376681 OAS3 -0.42 -5.93 -0.31 7.58e-9 Chronic lymphocytic leukemia; LUSC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg14689365 chr7:158441557 NCAPG2 0.51 7.4 0.38 1.13e-12 Height; LUSC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg06481639 chr22:41940642 POLR3H -0.54 -6.46 -0.33 3.63e-10 Vitiligo; LUSC trans rs9393777 0.778 rs4452638 chr6:27229265 A/G cg06606381 chr12:133084897 FBRSL1 0.65 7.08 0.36 8.52e-12 Intelligence (multi-trait analysis); LUSC cis rs4409675 0.576 rs7536088 chr1:28234325 A/G cg23691781 chr1:28212827 C1orf38 0.33 7.64 0.39 2.31e-13 Corneal astigmatism; LUSC cis rs8180040 0.764 rs2132173 chr3:47247060 C/T cg16586182 chr3:47516702 SCAP 0.5 7.85 0.39 5.59e-14 Colorectal cancer; LUSC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg03806693 chr22:41940476 POLR3H 0.94 13.9 0.61 5.76e-35 Vitiligo; LUSC cis rs977987 0.778 rs12929908 chr16:75462071 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg03929089 chr4:120376271 NA 0.95 15.5 0.65 3.26e-41 Coronary artery disease; LUSC cis rs6500602 0.893 rs4786489 chr16:4485527 G/A cg08645402 chr16:4508243 NA 0.52 8.37 0.42 1.59e-15 Schizophrenia; LUSC cis rs12912251 1.000 rs2172835 chr15:38990171 C/T cg01338139 chr15:38987640 C15orf53 -0.48 -6.54 -0.34 2.38e-10 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg14983838 chr19:29218262 NA 0.65 8.85 0.44 5.33e-17 Methadone dose in opioid dependence; LUSC cis rs11608355 1.000 rs930356 chr12:109852372 T/C cg19025524 chr12:109796872 NA -0.4 -6.35 -0.33 7.14e-10 Neuroticism; LUSC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg12927641 chr6:109611667 NA -0.43 -7.5 -0.38 5.64e-13 Reticulocyte fraction of red cells; LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg19318889 chr4:1322082 MAEA 0.43 6.91 0.35 2.44e-11 Obesity-related traits; LUSC cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg15790184 chr11:494944 RNH1 0.5 7.41 0.38 1.03e-12 Systemic lupus erythematosus; LUSC cis rs9549367 0.826 rs9549713 chr13:113905308 G/T cg00898013 chr13:113819073 PROZ -0.57 -8.06 -0.4 1.38e-14 Platelet distribution width; LUSC trans rs35110281 0.805 rs2838330 chr21:45023876 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 10.33 0.49 6.61e-22 Mean corpuscular volume; LUSC cis rs1062746 0.528 rs891092 chr16:87338226 G/A cg02258303 chr16:87377426 FBXO31 -0.56 -9.01 -0.44 1.66e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs793571 0.590 rs442495 chr15:59022615 T/C cg05156742 chr15:59063176 FAM63B 0.51 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs2046867 0.774 rs9820293 chr3:72876237 T/A cg25664220 chr3:72788482 NA -0.67 -11.7 -0.54 9.78e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg04586622 chr2:25135609 ADCY3 0.32 6.18 0.32 1.92e-9 Body mass index; LUSC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg14552801 chr7:65878734 NA -0.43 -6.13 -0.32 2.45e-9 Aortic root size; LUSC cis rs8044868 0.530 rs12446480 chr16:72056757 A/G cg16579770 chr16:72058938 DHODH 0.34 5.74 0.3 2.11e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg04518342 chr5:131593106 PDLIM4 0.4 7.56 0.38 3.91e-13 Blood metabolite levels; LUSC cis rs9814567 1.000 rs1814337 chr3:134200682 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.69 -0.6 3.63e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs2279817 0.775 rs35493100 chr1:17993120 C/T cg21791023 chr1:18019539 ARHGEF10L -0.49 -6.0 -0.31 5.24e-9 Neuroticism; LUSC cis rs6669072 0.647 rs2954561 chr1:91240853 G/A cg08895590 chr1:91227319 NA -0.39 -8.68 -0.43 1.81e-16 Cognitive function; LUSC cis rs754466 0.580 rs12356063 chr10:79558131 G/C cg17075019 chr10:79541650 NA -0.74 -11.77 -0.54 5.68e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7937682 0.889 rs2850247 chr11:111637202 C/A cg18187862 chr3:45730750 SACM1L -0.66 -8.79 -0.43 7.96e-17 Primary sclerosing cholangitis; LUSC cis rs968451 1.000 rs62228376 chr22:39701097 G/C cg17798944 chr22:39715225 SNORD43;RPL3 0.68 9.0 0.44 1.8e-17 Primary biliary cholangitis; LUSC trans rs11098499 0.866 rs12374244 chr4:120281972 A/T cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg27121462 chr16:89883253 FANCA 0.53 8.48 0.42 7.58e-16 Vitiligo; LUSC cis rs7267979 1.000 rs6050573 chr20:25366065 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.45 0.75 7.97e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg07777115 chr5:623756 CEP72 -0.46 -5.86 -0.31 1.09e-8 Obesity-related traits; LUSC trans rs208520 0.690 rs7739253 chr6:66861052 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -16.63 -0.67 1.16e-45 Exhaled nitric oxide output; LUSC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg21573476 chr21:45109991 RRP1B -0.38 -6.13 -0.32 2.51e-9 Mean corpuscular volume; LUSC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg18876405 chr7:65276391 NA 0.67 11.95 0.55 1.19e-27 Aortic root size; LUSC trans rs7710178 0.617 rs11951246 chr5:155987523 C/T cg05087909 chr2:9771142 YWHAQ -0.52 -6.03 -0.31 4.39e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg27266027 chr21:40555129 PSMG1 0.4 5.95 0.31 6.66e-9 Cognitive function; LUSC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg02187348 chr16:89574699 SPG7 0.64 10.59 0.5 8.86e-23 Multiple myeloma (IgH translocation); LUSC cis rs3812831 0.695 rs7998546 chr13:114939914 C/G cg08824895 chr13:115047677 UPF3A 0.55 8.42 0.42 1.09e-15 Schizophrenia; LUSC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.61 7.59 0.38 3.2e-13 Lung function (FEV1/FVC); LUSC cis rs61931739 0.517 rs11053067 chr12:34191391 T/C cg06521331 chr12:34319734 NA -0.45 -7.38 -0.37 1.29e-12 Morning vs. evening chronotype; LUSC cis rs79349575 0.783 rs318095 chr17:46974734 T/C cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs6901250 0.851 rs339360 chr6:117160872 G/T cg12892004 chr6:117198278 RFX6 -0.44 -8.24 -0.41 4e-15 C-reactive protein levels; LUSC cis rs4363385 0.818 rs378010 chr1:153007987 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -5.87 -0.31 1.04e-8 Inflammatory skin disease; LUSC cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs7617773 0.817 rs4131361 chr3:48328812 T/C cg20734569 chr3:48348370 SPINK8 -0.47 -8.17 -0.41 6.44e-15 Coronary artery disease; LUSC cis rs11756438 0.547 rs1343287 chr6:119001805 T/C cg18833306 chr6:118973337 C6orf204 0.36 5.75 0.3 2.04e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9314323 0.862 rs3808580 chr8:26250296 C/T cg13160058 chr8:26243215 BNIP3L 0.4 7.27 0.37 2.58e-12 Red cell distribution width; LUSC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg24675658 chr1:53192096 ZYG11B -0.61 -10.09 -0.48 4.38e-21 Monocyte count; LUSC cis rs10392 0.543 rs4812333 chr20:37536119 T/A cg27552599 chr20:37590471 DHX35 0.41 6.56 0.34 2.03e-10 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs6951245 1.000 rs11766526 chr7:1101433 G/A cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6601327 0.670 rs6990418 chr8:9422006 C/G cg06636001 chr8:8085503 FLJ10661 0.44 6.12 0.32 2.62e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg27398817 chr8:82754497 SNX16 -0.46 -6.17 -0.32 1.96e-9 Diastolic blood pressure; LUSC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg08773314 chr2:239334832 ASB1 0.42 9.08 0.45 9.38e-18 Multiple system atrophy; LUSC cis rs1044826 0.642 rs1080371 chr3:139210894 C/T cg15131784 chr3:139108705 COPB2 0.4 6.38 0.33 6.03e-10 Obesity-related traits; LUSC cis rs16854884 0.657 rs13078840 chr3:143700753 A/G cg06585982 chr3:143692056 C3orf58 0.45 6.86 0.35 3.29e-11 Economic and political preferences (feminism/equality); LUSC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs12165098 0.516 rs11082127 chr18:36744599 A/G cg23858286 chr9:138135095 NA -0.42 -6.16 -0.32 2.1e-9 Sleep duration; LUSC cis rs9311676 0.656 rs11915480 chr3:58377159 A/G cg26110898 chr3:58419937 PDHB 0.4 6.65 0.34 1.23e-10 Systemic lupus erythematosus; LUSC cis rs12908161 0.959 rs34784022 chr15:85231906 T/C cg17507749 chr15:85114479 UBE2QP1 0.56 6.96 0.36 1.8e-11 Schizophrenia; LUSC cis rs2625529 0.824 rs2279283 chr15:72243666 T/C cg16672083 chr15:72433130 SENP8 -0.49 -7.08 -0.36 8.38e-12 Red blood cell count; LUSC cis rs7208859 0.623 rs9894709 chr17:29078454 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.04 0.36 1.09e-11 Platelet count; LUSC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg18512352 chr11:47633146 NA -0.47 -9.6 -0.46 2.03e-19 Subjective well-being; LUSC cis rs7577696 0.962 rs11681731 chr2:32345325 A/T cg02381751 chr2:32503542 YIPF4 -0.4 -5.66 -0.3 3.23e-8 Inflammatory biomarkers; LUSC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.88 -0.31 9.79e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4631830 0.720 rs11004415 chr10:51498181 G/A cg20129853 chr10:51489980 NA 0.36 7.4 0.38 1.14e-12 Prostate-specific antigen levels; LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.49 0.46 4.51e-19 Bipolar disorder; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg10150615 chr22:24372951 LOC391322 -0.44 -7.36 -0.37 1.43e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs9943753 0.508 rs5013021 chr12:109790752 C/A cg19025524 chr12:109796872 NA -0.38 -6.89 -0.35 2.82e-11 HDL cholesterol; LUSC cis rs870825 0.616 rs6552804 chr4:185637699 A/G cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC trans rs7824557 0.564 rs1435275 chr8:11235735 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -7.53 -0.38 4.91e-13 Retinal vascular caliber; LUSC cis rs7589342 0.628 rs11886675 chr2:106409118 G/T cg14210321 chr2:106509881 NCK2 -0.46 -5.87 -0.31 1.04e-8 Addiction; LUSC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg04352962 chr1:209979756 IRF6 0.52 6.16 0.32 2.13e-9 Cleft lip with or without cleft palate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11747516 chr1:2518503 C1orf93 -0.4 -6.01 -0.31 4.78e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7523273 0.606 rs2724387 chr1:207932617 T/G cg22525895 chr1:207977042 MIR29B2 0.41 6.66 0.34 1.14e-10 Schizophrenia; LUSC cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg24642439 chr20:33292090 TP53INP2 0.5 7.56 0.38 3.81e-13 Height; LUSC cis rs1003719 0.707 rs9976360 chr21:38587860 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.23 -0.49 1.53e-21 Eye color traits; LUSC cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.89 -0.31 9.56e-9 Tonsillectomy; LUSC cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11155671 0.530 rs9371215 chr6:150194298 C/T cg04369109 chr6:150039330 LATS1 -0.43 -6.19 -0.32 1.76e-9 Testicular germ cell tumor; LUSC cis rs911119 1.000 rs6048956 chr20:23609301 C/T cg16589663 chr20:23618590 CST3 0.59 6.96 0.36 1.8e-11 Chronic kidney disease; LUSC trans rs2243480 1.000 rs10950032 chr7:65738591 C/A cg10756647 chr7:56101905 PSPH -0.87 -8.66 -0.43 2.02e-16 Diabetic kidney disease; LUSC cis rs4792901 0.722 rs12603085 chr17:41545847 G/A cg22562494 chr17:41607896 ETV4 -0.32 -6.02 -0.31 4.69e-9 Dupuytren's disease; LUSC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.64 0.47 1.49e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9807989 0.811 rs11688573 chr2:102969971 C/A cg09003973 chr2:102972529 NA 0.44 6.04 0.31 4.15e-9 Asthma; LUSC cis rs2629751 0.512 rs2723845 chr12:104446721 T/C cg14987745 chr12:104360022 TDG -0.7 -8.37 -0.42 1.54e-15 Hepatitis C induced liver fibrosis; LUSC cis rs4561483 0.801 rs33620 chr16:12008546 C/G cg08843971 chr16:11963173 GSPT1 -0.49 -7.46 -0.38 7.71e-13 Testicular germ cell tumor; LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg03352830 chr11:487213 PTDSS2 0.69 8.64 0.43 2.43e-16 Body mass index; LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg05025164 chr4:1340916 KIAA1530 0.42 6.23 0.32 1.39e-9 Obesity-related traits; LUSC cis rs16854884 0.586 rs6796460 chr3:143756367 G/A cg06585982 chr3:143692056 C3orf58 0.51 8.26 0.41 3.45e-15 Economic and political preferences (feminism/equality); LUSC cis rs754466 1.000 rs2278218 chr10:79680399 G/A cg17075019 chr10:79541650 NA -0.64 -8.4 -0.42 1.32e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1577917 0.655 rs9444354 chr6:86291935 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 7.19 0.37 4.18e-12 Response to antipsychotic treatment; LUSC cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg15839431 chr19:19639596 YJEFN3 -0.59 -6.2 -0.32 1.62e-9 Bipolar disorder; LUSC cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg09025071 chr16:1593152 IFT140;TMEM204 0.3 6.69 0.34 9.4e-11 Coronary artery disease; LUSC cis rs4704187 0.687 rs4361493 chr5:74405097 A/G cg03227963 chr5:74354835 NA 0.33 7.07 0.36 8.83e-12 Response to amphetamines; LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03576123 chr11:487126 PTDSS2 -1.1 -11.52 -0.53 4.56e-26 Body mass index; LUSC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg09165964 chr15:75287851 SCAMP5 -0.48 -7.16 -0.36 5.05e-12 Breast cancer; LUSC cis rs2285947 1.000 rs6970985 chr7:21583597 G/T cg04471919 chr7:21584483 DNAH11 0.34 7.73 0.39 1.29e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs6500395 1.000 rs7195684 chr16:48710750 G/A cg04672837 chr16:48644449 N4BP1 -0.47 -6.98 -0.36 1.62e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg09365446 chr1:150670422 GOLPH3L -0.48 -7.14 -0.36 5.89e-12 Melanoma; LUSC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg01475377 chr6:109611718 NA -0.46 -8.44 -0.42 1e-15 Reticulocyte fraction of red cells; LUSC cis rs10426930 0.671 rs57900491 chr19:4995295 A/T cg25246084 chr19:4971487 KDM4B -0.34 -6.19 -0.32 1.76e-9 Monocyte percentage of white cells; LUSC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.46 -7.86 -0.4 5.19e-14 Total body bone mineral density; LUSC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2e-10 Reticulocyte fraction of red cells; LUSC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs2370759 1.000 rs77165999 chr10:32577131 T/C cg01819863 chr10:32635814 EPC1 1.08 13.44 0.59 3.21e-33 Sexual dysfunction (female); LUSC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg13607699 chr17:42295918 UBTF 0.75 13.68 0.6 3.96e-34 Total body bone mineral density; LUSC cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg21535247 chr6:8435926 SLC35B3 0.56 8.56 0.42 4.06e-16 Motion sickness; LUSC cis rs8077889 0.719 rs4793033 chr17:41879627 C/T cg26893861 chr17:41843967 DUSP3 1.0 18.88 0.72 1.29e-54 Triglycerides; LUSC cis rs921665 0.680 rs4411731 chr2:3189324 C/A cg16434511 chr2:3151078 NA -0.63 -6.78 -0.35 5.3e-11 World class endurance athleticism; LUSC cis rs208520 0.874 rs208470 chr6:66916402 G/A cg07460842 chr6:66804631 NA -1.01 -14.37 -0.62 8.5e-37 Exhaled nitric oxide output; LUSC cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.62 0.43 2.82e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg04166393 chr7:2884313 GNA12 0.46 6.03 0.31 4.26e-9 Height; LUSC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg24675056 chr1:15929824 NA 0.44 7.65 0.39 2.11e-13 Systolic blood pressure; LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg03517284 chr6:25882590 NA -0.52 -9.67 -0.47 1.16e-19 Blood metabolite levels; LUSC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg03806693 chr22:41940476 POLR3H 0.94 13.57 0.6 1.01e-33 Vitiligo; LUSC trans rs6598955 0.671 rs11247893 chr1:26597086 A/C cg07461501 chr17:79650226 HGS;ARL16 0.62 8.4 0.42 1.28e-15 Obesity-related traits; LUSC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg26380479 chr7:97908229 NA -0.28 -6.27 -0.32 1.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs887829 0.570 rs4347832 chr2:234593041 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -6.16 -0.32 2.13e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg11752832 chr7:134001865 SLC35B4 0.55 8.46 0.42 8.45e-16 Mean platelet volume; LUSC cis rs3008870 1.000 rs12039172 chr1:67447450 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.11 -0.64 1.09e-39 Lymphocyte percentage of white cells; LUSC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg17633681 chr16:88106987 BANP 0.53 10.16 0.49 2.64e-21 Menopause (age at onset); LUSC cis rs72781680 0.898 rs17762609 chr2:24114729 G/T cg08917208 chr2:24149416 ATAD2B 0.87 9.73 0.47 7.07e-20 Lymphocyte counts; LUSC cis rs7512552 0.803 rs9436127 chr1:150490565 G/A cg15654264 chr1:150340011 RPRD2 0.6 9.71 0.47 8.82e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs992157 0.965 rs13419763 chr2:219134950 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.55 8.31 0.41 2.49e-15 Colorectal cancer; LUSC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg10556349 chr10:835070 NA 0.59 6.55 0.34 2.24e-10 Eosinophil percentage of granulocytes; LUSC cis rs611744 0.647 rs7015513 chr8:109262570 A/C cg18478394 chr8:109455254 TTC35 0.42 6.47 0.33 3.57e-10 Dupuytren's disease; LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg22963979 chr7:1858916 MAD1L1 -0.65 -10.71 -0.51 3.4e-23 Bipolar disorder and schizophrenia; LUSC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg11861562 chr11:117069780 TAGLN 0.45 8.16 0.41 6.97e-15 Blood protein levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04346879 chr19:4402785 CHAF1A -0.5 -6.05 -0.31 3.83e-9 Bipolar disorder and schizophrenia; LUSC cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.43 -6.61 -0.34 1.56e-10 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.913 rs11228262 chr11:68274907 G/T cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.13e-9 Total body bone mineral density; LUSC cis rs17270561 0.636 rs12194699 chr6:25729229 G/C cg16482183 chr6:26056742 HIST1H1C 0.64 9.02 0.44 1.49e-17 Iron status biomarkers; LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.66 0.6 4.84e-34 Platelet count; LUSC trans rs10517480 0.806 rs9996588 chr4:60764949 G/A cg15257681 chr4:727544 PCGF3 0.35 5.97 0.31 5.93e-9 Metabolite levels; LUSC cis rs524023 1.000 rs505802 chr11:64357072 T/C cg19131476 chr11:64387923 NRXN2 0.37 9.91 0.48 1.88e-20 Urate levels in obese individuals; LUSC trans rs4689388 0.926 rs11725494 chr4:6293855 C/T cg17567195 chr5:167378696 ODZ2 -0.39 -6.24 -0.32 1.35e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7202877 0.706 rs11149812 chr16:75323645 T/C cg03315344 chr16:75512273 CHST6 0.42 6.19 0.32 1.72e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs2692947 0.673 rs2692894 chr2:96784934 T/G cg22654517 chr2:96458247 NA -0.31 -5.84 -0.3 1.23e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.89 12.61 0.57 4.5e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs453301 0.653 rs1562211 chr8:8902424 A/G cg21775007 chr8:11205619 TDH -0.45 -6.51 -0.34 2.82e-10 Joint mobility (Beighton score); LUSC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg11244672 chr19:19639970 YJEFN3 -0.58 -7.38 -0.37 1.27e-12 Bipolar disorder; LUSC cis rs9611565 0.694 rs5758411 chr22:42079734 G/A cg03806693 chr22:41940476 POLR3H 0.86 12.66 0.57 2.85e-30 Vitiligo; LUSC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.66 0.39 2.01e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg22467129 chr15:76604101 ETFA -0.45 -7.19 -0.37 4.36e-12 Blood metabolite levels; LUSC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12756686 chr19:29218302 NA 0.71 11.17 0.52 8.16e-25 Methadone dose in opioid dependence; LUSC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.87 0.31 1.03e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7580658 0.895 rs7589451 chr2:128128775 T/C cg09760422 chr2:128146352 NA -0.29 -6.26 -0.32 1.18e-9 Protein C levels; LUSC cis rs2011503 0.509 rs10403579 chr19:19770329 T/C cg11584989 chr19:19387371 SF4 0.51 5.72 0.3 2.37e-8 Bipolar disorder; LUSC cis rs4478858 0.735 rs7547897 chr1:31797593 G/A cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg18876405 chr7:65276391 NA -0.54 -8.57 -0.42 3.82e-16 Aortic root size; LUSC trans rs9929218 0.911 rs4783686 chr16:68834156 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.21 -0.52 5.78e-25 Colorectal cancer; LUSC cis rs737008 1.000 rs737008 chr16:11374866 G/T cg00044050 chr16:11439710 C16orf75 -0.52 -7.88 -0.4 4.65e-14 Obesity-related traits; LUSC cis rs7174348 1 rs7174348 chr15:78792439 G/A cg18825076 chr15:78729989 IREB2 0.46 6.45 0.33 4.04e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg14159672 chr1:205819179 PM20D1 0.53 8.71 0.43 1.39e-16 Menarche (age at onset); LUSC cis rs1003719 0.788 rs2835574 chr21:38455324 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.41 0.53 1.1e-25 Eye color traits; LUSC cis rs10875746 0.551 rs2054903 chr12:48724493 C/T cg13454099 chr12:49076203 C12orf41 -0.51 -5.65 -0.3 3.52e-8 Longevity (90 years and older); LUSC cis rs10887741 0.690 rs4934357 chr10:89439533 G/A cg13926569 chr10:89418898 PAPSS2 0.34 7.42 0.38 9.91e-13 Exercise (leisure time); LUSC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg13206674 chr6:150067644 NUP43 0.56 8.89 0.44 3.91e-17 Lung cancer; LUSC cis rs7903847 0.642 rs11189172 chr10:99135215 T/C cg20016023 chr10:99160130 RRP12 -0.37 -8.72 -0.43 1.36e-16 Granulocyte percentage of myeloid white cells; LUSC trans rs1541010 0.762 rs7912523 chr10:13767732 C/G cg04685003 chr17:57696515 CLTC 0.43 6.21 0.32 1.59e-9 RR interval (heart rate); LUSC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg24531977 chr5:56204891 C5orf35 -0.56 -8.52 -0.42 5.75e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs56104184 0.830 rs73061617 chr19:49350984 G/A cg15549821 chr19:49342101 PLEKHA4 -0.9 -10.62 -0.5 6.81e-23 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs10823500 0.604 rs10762345 chr10:71939374 A/G cg26699283 chr10:71892715 AIFM2 -0.38 -6.18 -0.32 1.92e-9 Blood protein levels; LUSC cis rs4363385 0.818 rs1750309 chr1:153013630 G/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.71 -0.39 1.41e-13 Inflammatory skin disease; LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg07167872 chr1:205819463 PM20D1 0.53 9.11 0.45 7.48e-18 Menarche (age at onset); LUSC cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg01579765 chr21:45077557 HSF2BP -0.48 -9.94 -0.48 1.41e-20 Mean corpuscular volume; LUSC cis rs11105298 0.891 rs12369685 chr12:89928905 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.17 -0.37 4.83e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg26597838 chr10:835615 NA 0.84 11.66 0.54 1.33e-26 Eosinophil percentage of granulocytes; LUSC cis rs1065656 0.553 rs344357 chr16:1836255 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.44 -6.19 -0.32 1.77e-9 Insulin-like growth factors; LUSC cis rs17253792 0.915 rs79100824 chr14:56179606 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs68170813 0.559 rs80153759 chr7:106944145 C/A cg02696742 chr7:106810147 HBP1 -0.64 -9.7 -0.47 8.88e-20 Coronary artery disease; LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg00431813 chr7:1051703 C7orf50 -0.43 -6.99 -0.36 1.5e-11 Longevity;Endometriosis; LUSC cis rs17270561 0.666 rs9356987 chr6:25739187 C/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.46 6.36 0.33 6.49e-10 Multiple sclerosis; LUSC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg16049864 chr8:95962084 TP53INP1 -0.49 -8.77 -0.43 9.11e-17 Type 2 diabetes; LUSC cis rs1595825 0.891 rs4422151 chr2:198544183 A/T cg00982548 chr2:198649783 BOLL -0.56 -6.94 -0.35 2.09e-11 Ulcerative colitis; LUSC cis rs2732480 0.577 rs1489108 chr12:48738781 G/A cg21466736 chr12:48725269 NA -0.32 -5.65 -0.3 3.49e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs56077333 1 rs56077333 chr15:78899003 C/A cg18825076 chr15:78729989 IREB2 -0.52 -8.05 -0.4 1.45e-14 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1784581 0.722 rs1621456 chr6:162399985 C/T cg17173639 chr6:162384350 PARK2 -0.66 -11.63 -0.54 1.74e-26 Itch intensity from mosquito bite; LUSC cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.19 0.37 4.33e-12 Motion sickness; LUSC cis rs4654899 0.758 rs9426652 chr1:21458151 G/A cg01072550 chr1:21505969 NA -0.53 -7.99 -0.4 2.16e-14 Superior frontal gyrus grey matter volume; LUSC cis rs7100689 0.784 rs7082102 chr10:82104890 A/C cg00277334 chr10:82204260 NA -0.5 -7.16 -0.36 5.24e-12 Post bronchodilator FEV1; LUSC trans rs9944715 0.954 rs8094706 chr18:43770146 A/G cg01718231 chr17:29326311 RNF135 -0.48 -7.15 -0.36 5.52e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg02772935 chr3:125709198 NA -0.47 -6.04 -0.31 4.14e-9 Blood pressure (smoking interaction); LUSC cis rs6570726 0.935 rs367612 chr6:145828987 A/G cg05347473 chr6:146136440 FBXO30 0.4 6.78 0.35 5.5e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs909341 0.909 rs2427530 chr20:62361737 G/A cg09650180 chr20:62225654 GMEB2 -0.47 -6.11 -0.32 2.75e-9 Atopic dermatitis; LUSC cis rs7107174 1.000 rs2510048 chr11:77987464 T/C cg02023728 chr11:77925099 USP35 0.48 6.82 0.35 4.26e-11 Testicular germ cell tumor; LUSC cis rs68170813 0.559 rs79778437 chr7:107004972 T/A cg02696742 chr7:106810147 HBP1 -0.61 -9.29 -0.45 2.08e-18 Coronary artery disease; LUSC cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg13319975 chr6:146136371 FBXO30 0.49 7.47 0.38 7.15e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1691799 0.899 rs1168302 chr12:66737518 C/T cg16791601 chr12:66731901 HELB -0.7 -12.18 -0.55 1.72e-28 White blood cell count (basophil); LUSC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg05754148 chr16:3507555 NAT15 0.8 9.8 0.47 4.18e-20 Tuberculosis; LUSC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -8.0 -0.4 2.05e-14 Lymphocyte counts; LUSC cis rs1018836 0.892 rs7819519 chr8:91565504 C/T cg16814680 chr8:91681699 NA -0.69 -10.98 -0.52 3.69e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs225245 0.694 rs321616 chr17:33882720 C/T cg19694781 chr19:47549865 TMEM160 -0.39 -6.36 -0.33 6.65e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9527 0.590 rs1807298 chr10:104870218 G/A cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg24977027 chr2:88469347 THNSL2 -0.57 -5.83 -0.3 1.3e-8 Plasma clusterin levels; LUSC cis rs6445967 0.722 rs6445961 chr3:58232659 C/T cg23715586 chr3:58305044 RPP14 0.5 8.71 0.43 1.4e-16 Platelet count; LUSC cis rs921968 0.541 rs12619347 chr2:219419935 T/C cg02176678 chr2:219576539 TTLL4 -0.74 -14.17 -0.61 4.95e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs9341808 0.519 rs676311 chr6:80989750 T/G cg08355045 chr6:80787529 NA -0.42 -7.17 -0.37 4.93e-12 Sitting height ratio; LUSC cis rs28829049 0.597 rs12566296 chr1:19498443 A/C cg13387374 chr1:19411106 UBR4 0.44 6.13 0.32 2.44e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg21535247 chr6:8435926 SLC35B3 0.58 9.13 0.45 6.72e-18 Motion sickness; LUSC cis rs6951245 0.572 rs80133931 chr7:1027286 C/T cg24642844 chr7:1081250 C7orf50 -0.76 -6.94 -0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4356932 0.967 rs28433437 chr4:76972653 A/G cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.43 0.38 9.18e-13 Menarche (age at onset); LUSC cis rs17030434 0.953 rs10014299 chr4:154700858 A/G cg14289246 chr4:154710475 SFRP2 -0.5 -6.56 -0.34 2.08e-10 Electrocardiographic conduction measures; LUSC cis rs1007190 0.881 rs3816275 chr17:42957327 G/A cg15406952 chr17:42872593 NA 0.55 5.68 0.3 2.97e-8 DNA methylation (variation); LUSC cis rs1595825 0.891 rs1016883 chr2:198881668 A/G cg10547527 chr2:198650123 BOLL 0.52 6.34 0.33 7.52e-10 Ulcerative colitis; LUSC cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg24642439 chr20:33292090 TP53INP2 -0.51 -7.67 -0.39 1.91e-13 Glomerular filtration rate (creatinine); LUSC cis rs7000551 0.556 rs12674913 chr8:22263617 G/C cg12081754 chr8:22256438 SLC39A14 0.91 13.77 0.6 1.81e-34 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8077889 0.917 rs72836545 chr17:41892602 A/G cg26893861 chr17:41843967 DUSP3 0.95 14.72 0.63 3.72e-38 Triglycerides; LUSC cis rs12748961 0.557 rs823127 chr1:205713139 G/A cg11965913 chr1:205819406 PM20D1 0.46 5.92 0.31 8.18e-9 White blood cell types; LUSC cis rs76878669 0.561 rs2236679 chr11:66108894 G/C cg18002602 chr11:66138449 SLC29A2 -0.49 -8.69 -0.43 1.71e-16 Educational attainment (years of education); LUSC cis rs9811920 0.535 rs704572 chr3:99482314 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.3 -5.79 -0.3 1.61e-8 Axial length; LUSC cis rs9677476 0.818 rs7598728 chr2:232086055 C/T cg07929768 chr2:232055508 NA 0.36 6.79 0.35 4.99e-11 Food antigen IgG levels; LUSC cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg05040210 chr1:18807594 KLHDC7A -0.39 -7.11 -0.36 7.13e-12 Breast cancer; LUSC cis rs273573 0.922 rs927224 chr11:30810665 T/C cg14844989 chr11:31128820 NA -0.37 -5.78 -0.3 1.67e-8 Total body bone mineral density; LUSC cis rs4704187 0.687 rs10051422 chr5:74502573 G/A cg03227963 chr5:74354835 NA 0.3 6.64 0.34 1.24e-10 Response to amphetamines; LUSC cis rs9443645 0.527 rs949846 chr6:79817596 C/T cg05283184 chr6:79620031 NA -0.46 -8.7 -0.43 1.58e-16 Intelligence (multi-trait analysis); LUSC cis rs9399401 0.601 rs643975 chr6:142844251 C/G cg03128060 chr6:142623767 GPR126 -0.51 -8.86 -0.44 4.84e-17 Chronic obstructive pulmonary disease; LUSC trans rs1005277 0.602 rs1740743 chr10:38519222 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.51 -0.46 3.89e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7100689 0.577 rs7901663 chr10:82153488 C/G cg01528321 chr10:82214614 TSPAN14 0.83 12.69 0.57 2.27e-30 Post bronchodilator FEV1; LUSC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs908922 0.676 rs2105117 chr1:152484129 G/A cg20991723 chr1:152506922 NA 0.52 9.58 0.46 2.27e-19 Hair morphology; LUSC cis rs4727027 0.704 rs4727031 chr7:148908305 T/C cg23158103 chr7:148848205 ZNF398 -0.42 -6.85 -0.35 3.5e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15541040 chr2:3486749 NA 0.56 8.67 0.43 1.92e-16 Neurofibrillary tangles; LUSC cis rs4363385 0.818 rs61811863 chr1:152995721 T/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.92 -0.4 3.57e-14 Inflammatory skin disease; LUSC cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg25282410 chr6:160211355 TCP1;MRPL18 1.13 17.23 0.69 4.9e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs12760731 0.720 rs10913542 chr1:178348568 A/G cg00404053 chr1:178313656 RASAL2 0.48 5.82 0.3 1.38e-8 Obesity-related traits; LUSC cis rs4073582 0.595 rs801734 chr11:65931216 T/C cg16950941 chr11:66035639 RAB1B 0.5 7.28 0.37 2.34e-12 Gout; LUSC cis rs11098499 0.866 rs13105020 chr4:120285688 G/T cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs7605827 0.930 rs11681344 chr2:15711885 C/A cg19274914 chr2:15703543 NA 0.45 8.44 0.42 9.9e-16 Educational attainment (years of education); LUSC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg01770232 chr7:22766155 IL6 0.4 5.73 0.3 2.27e-8 Lung cancer; LUSC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.9 -0.35 2.64e-11 Monocyte percentage of white cells; LUSC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg15316289 chr22:50310904 ALG12;CRELD2 0.53 8.02 0.4 1.76e-14 Schizophrenia; LUSC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg17971929 chr21:40555470 PSMG1 0.77 13.48 0.59 2.3e-33 Cognitive function; LUSC cis rs9818941 0.824 rs1574064 chr3:157801204 C/G cg08654915 chr3:157813417 NA -0.32 -7.57 -0.38 3.57e-13 Height; LUSC cis rs911119 1.000 rs3088162 chr20:23607752 C/A cg16589663 chr20:23618590 CST3 0.61 7.19 0.37 4.24e-12 Chronic kidney disease; LUSC cis rs4474465 0.850 rs10793327 chr11:78256841 A/C cg27205649 chr11:78285834 NARS2 0.53 6.46 0.33 3.72e-10 Alzheimer's disease (survival time); LUSC cis rs963731 0.579 rs4670269 chr2:39198036 C/T cg04010122 chr2:39346883 SOS1 0.67 5.83 0.3 1.3e-8 Corticobasal degeneration; LUSC cis rs4969178 0.931 rs6501208 chr17:76395038 A/T cg05887092 chr17:76393375 PGS1 0.52 9.5 0.46 4.27e-19 HDL cholesterol levels; LUSC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg11812906 chr14:75593930 NEK9 0.66 11.33 0.53 2.12e-25 Height; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg05025164 chr4:1340916 KIAA1530 0.42 6.7 0.34 8.83e-11 Longevity; LUSC cis rs734999 0.588 rs2985859 chr1:2532416 T/C cg18854424 chr1:2615690 NA -0.49 -9.83 -0.47 3.4e-20 Ulcerative colitis; LUSC trans rs853679 0.607 rs17763089 chr6:27835218 G/A cg06606381 chr12:133084897 FBRSL1 -1.02 -9.08 -0.44 9.93e-18 Depression; LUSC cis rs1728785 1.000 rs1645935 chr16:68563791 A/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC trans rs7618501 0.601 rs2624825 chr3:50154989 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -8.54 -0.42 4.97e-16 Intelligence (multi-trait analysis); LUSC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg14784868 chr12:69753453 YEATS4 0.9 16.15 0.66 9.23e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg12963246 chr6:28129442 ZNF389 0.41 6.44 0.33 4.24e-10 Parkinson's disease; LUSC cis rs11971779 0.715 rs7781459 chr7:139093882 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg26408565 chr15:76604113 ETFA -0.5 -8.02 -0.4 1.82e-14 Blood metabolite levels; LUSC cis rs3857536 0.740 rs9342532 chr6:66886297 T/C cg07460842 chr6:66804631 NA -0.46 -6.47 -0.33 3.5e-10 Blood trace element (Cu levels); LUSC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.52e-8 Extrinsic epigenetic age acceleration; LUSC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg05535760 chr7:792225 HEATR2 0.95 10.13 0.48 3.4e-21 Cerebrospinal P-tau181p levels; LUSC cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg08807101 chr21:30365312 RNF160 -0.54 -8.2 -0.41 5.09e-15 Dental caries; LUSC cis rs79349575 0.783 rs1994970 chr17:47014127 C/T cg22482690 chr17:47019901 SNF8 -0.38 -7.25 -0.37 2.92e-12 Type 2 diabetes; LUSC cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.05 0.58 9.94e-32 Platelet count; LUSC cis rs9309473 0.519 rs2421545 chr2:73639476 T/C cg20560298 chr2:73613845 ALMS1 0.47 7.4 0.38 1.13e-12 Metabolite levels; LUSC cis rs2280018 0.963 rs12928424 chr16:15150773 C/G cg27102117 chr16:15229624 NA 0.41 7.14 0.36 5.96e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6582630 0.638 rs12423236 chr12:38548162 G/A cg26384229 chr12:38710491 ALG10B -0.54 -8.16 -0.41 6.75e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs4474465 0.790 rs4492845 chr11:78260161 C/T cg27205649 chr11:78285834 NARS2 0.53 6.46 0.33 3.72e-10 Alzheimer's disease (survival time); LUSC cis rs9300255 0.550 rs10772997 chr12:123719880 C/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.38 -0.33 5.87e-10 Neutrophil percentage of white cells; LUSC cis rs1728785 0.818 rs11075684 chr16:68582365 C/T cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.42e-9 Ulcerative colitis; LUSC cis rs243505 0.733 rs9987055 chr7:148501758 G/A cg09806900 chr7:148480153 CUL1 0.55 8.09 0.4 1.09e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg18099408 chr3:52552593 STAB1 -0.41 -6.93 -0.35 2.17e-11 Bipolar disorder; LUSC trans rs2679649 1.000 rs2684268 chr6:122354079 T/C cg00167820 chr8:131663355 NA 0.54 6.3 0.33 9.21e-10 Subcutaneous adipose tissue; LUSC cis rs9650315 0.733 rs55771752 chr8:57206332 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg03605463 chr16:89740564 NA 0.59 9.39 0.46 9.44e-19 Vitiligo; LUSC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -7.24 -0.37 3.11e-12 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.57 0.78 3.62e-69 Prudent dietary pattern; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg23034840 chr1:205782522 SLC41A1 0.51 7.03 0.36 1.18e-11 Menarche (age at onset); LUSC cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg26384229 chr12:38710491 ALG10B 0.84 14.47 0.62 3.51e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs11645898 0.748 rs72791120 chr16:72224583 G/T cg14768367 chr16:72042858 DHODH -0.57 -6.16 -0.32 2.13e-9 Blood protein levels; LUSC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg15691649 chr6:25882328 NA -0.4 -5.75 -0.3 1.97e-8 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.05 -0.31 3.93e-9 Platelet count; LUSC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg11663144 chr21:46675770 NA -0.41 -6.97 -0.36 1.66e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.25 0.45 2.83e-18 Monocyte percentage of white cells; LUSC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg07211511 chr3:129823064 LOC729375 -0.62 -8.21 -0.41 4.72e-15 Blood pressure (smoking interaction); LUSC trans rs10506458 0.834 rs73127067 chr12:63390333 G/T cg22491629 chr6:157744540 C6orf35 -0.91 -10.85 -0.51 1.06e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg25554036 chr4:6271136 WFS1 0.58 11.94 0.55 1.29e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6977660 0.619 rs71526305 chr7:19785374 G/C cg07541023 chr7:19748670 TWISTNB 0.61 6.46 0.33 3.63e-10 Thyroid stimulating hormone; LUSC trans rs2228479 0.764 rs7191836 chr16:89961597 T/C cg24644049 chr4:85504048 CDS1 0.74 7.45 0.38 7.81e-13 Skin colour saturation; LUSC cis rs17533156 0.612 rs12603478 chr17:75128651 A/G cg11416367 chr17:75137675 SEC14L1 0.5 5.91 0.31 8.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4462272 0.554 rs7068215 chr10:101859870 C/T cg02250046 chr10:101825185 CPN1 0.33 6.0 0.31 5.05e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9527 0.590 rs4917992 chr10:104786313 G/A cg05855489 chr10:104503620 C10orf26 0.53 7.87 0.4 4.96e-14 Arsenic metabolism; LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg22549504 chr19:17448937 GTPBP3 0.55 7.06 0.36 9.83e-12 Systemic lupus erythematosus; LUSC cis rs10740039 0.842 rs10821819 chr10:62418615 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs548181 0.611 rs562599 chr11:125459951 A/C cg03464685 chr11:125439445 EI24 1.28 13.82 0.6 1.1e-34 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg25456477 chr12:86230367 RASSF9 0.37 6.43 0.33 4.34e-10 Major depressive disorder; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg09877947 chr5:131593287 PDLIM4 0.43 6.81 0.35 4.56e-11 Breast cancer; LUSC cis rs1997103 1.000 rs7779040 chr7:55412947 T/C cg17469321 chr7:55412551 NA 0.65 10.53 0.5 1.45e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4363385 0.747 rs9919227 chr1:152970867 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.74 -0.39 1.21e-13 Inflammatory skin disease; LUSC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.95 -0.31 6.63e-9 Neutrophil percentage of white cells; LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg16362232 chr11:430036 ANO9 0.6 7.87 0.4 4.86e-14 Body mass index; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg25569575 chr11:67007811 KDM2A 0.36 5.99 0.31 5.42e-9 Schizophrenia; LUSC cis rs9300255 0.722 rs10773008 chr12:123800820 A/G cg13010344 chr12:123464640 ARL6IP4 -0.5 -6.42 -0.33 4.76e-10 Neutrophil percentage of white cells; LUSC cis rs10911232 0.507 rs28477876 chr1:183019882 T/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.89 0.51 8.07e-24 Hypertriglyceridemia; LUSC cis rs6696846 0.936 rs1042831 chr1:205043250 G/C cg21545522 chr1:205238299 TMCC2 0.46 8.41 0.42 1.21e-15 Red blood cell count; LUSC trans rs2797160 1.000 rs1612249 chr6:126014916 C/A cg05039488 chr6:79577232 IRAK1BP1 0.45 6.74 0.35 7.03e-11 Endometrial cancer; LUSC cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg05343316 chr1:45956843 TESK2 0.69 8.97 0.44 2.16e-17 Platelet count; LUSC cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg26446133 chr18:72167187 CNDP2 -0.79 -10.62 -0.5 6.95e-23 Refractive error; LUSC cis rs2980439 0.607 rs2980419 chr8:8114141 A/T cg06636001 chr8:8085503 FLJ10661 0.87 14.66 0.63 6.57e-38 Neuroticism; LUSC cis rs67478160 0.609 rs6576003 chr14:104291330 C/A cg08213375 chr14:104286397 PPP1R13B 0.44 8.5 0.42 6.43e-16 Schizophrenia; LUSC cis rs10979 0.644 rs12527367 chr6:143918718 C/T cg25407410 chr6:143891975 LOC285740 -0.49 -7.54 -0.38 4.54e-13 Hypospadias; LUSC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.74 11.56 0.53 3.05e-26 Hip circumference adjusted for BMI; LUSC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg06740227 chr12:86229804 RASSF9 0.39 6.25 0.32 1.23e-9 Major depressive disorder; LUSC cis rs926938 0.563 rs360661 chr1:115455280 G/A cg01522456 chr1:115632236 TSPAN2 -0.41 -6.28 -0.32 1.05e-9 Autism; LUSC cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg05347473 chr6:146136440 FBXO30 0.53 8.88 0.44 4.06e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs1595825 0.891 rs76637837 chr2:198529496 G/A cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.34e-10 Ulcerative colitis; LUSC cis rs4499344 0.633 rs259229 chr19:33134425 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.73 -10.84 -0.51 1.13e-23 Mean platelet volume; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg18876405 chr7:65276391 NA 0.53 8.61 0.43 2.86e-16 Calcium levels; LUSC cis rs7577696 0.962 rs4952248 chr2:32343669 G/A cg02381751 chr2:32503542 YIPF4 -0.4 -5.71 -0.3 2.47e-8 Inflammatory biomarkers; LUSC cis rs698833 0.506 rs713448 chr2:44504877 T/C cg00619915 chr2:44497795 NA -0.5 -6.92 -0.35 2.33e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs1891275 0.515 rs1361552 chr10:93534624 T/C cg07889827 chr10:93443413 NA -0.4 -9.07 -0.44 1.04e-17 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg26513180 chr16:89883248 FANCA 0.53 7.93 0.4 3.4e-14 Vitiligo; LUSC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.53 0.62 2.03e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg08742575 chr21:47604166 C21orf56 0.45 6.74 0.35 7e-11 Testicular germ cell tumor; LUSC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg27532560 chr4:187881888 NA -0.39 -6.41 -0.33 5.1e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7582720 1.000 rs35212307 chr2:203765756 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.66 0.43 2.06e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1124376 0.505 rs9854447 chr3:20305234 A/G cg05072819 chr3:20081367 KAT2B 0.58 5.76 0.3 1.96e-8 Bipolar disorder and schizophrenia; LUSC trans rs61931739 0.500 rs7489132 chr12:34539712 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs12995491 0.933 rs7590305 chr2:88513131 C/T cg18302933 chr2:88491318 NA -0.35 -6.8 -0.35 4.82e-11 Response to metformin (IC50); LUSC cis rs79387448 0.745 rs7587856 chr2:103144305 C/A cg09003973 chr2:102972529 NA 0.88 8.67 0.43 1.93e-16 Gut microbiota (bacterial taxa); LUSC cis rs6700896 0.966 rs12067936 chr1:66088701 C/A cg04111102 chr1:66153794 NA 0.32 7.04 0.36 1.11e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg05368731 chr17:41323189 NBR1 0.82 13.47 0.59 2.59e-33 Menopause (age at onset); LUSC trans rs8073060 0.586 rs4796101 chr17:33998593 C/T cg19694781 chr19:47549865 TMEM160 -1.14 -18.03 -0.7 3.05e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs459571 0.839 rs10993895 chr9:136887726 C/T cg13789015 chr9:136890014 NCRNA00094 -0.64 -11.92 -0.55 1.55e-27 Platelet distribution width; LUSC cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg16482183 chr6:26056742 HIST1H1C 0.49 7.38 0.37 1.3e-12 Height; LUSC cis rs11711311 1.000 rs2566970 chr3:113462123 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.52 -7.25 -0.37 2.87e-12 IgG glycosylation; LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg08645402 chr16:4508243 NA 0.48 7.45 0.38 8.16e-13 Schizophrenia; LUSC cis rs356992 0.915 rs76673 chr2:60749078 G/T cg08426369 chr2:60753602 BCL11A -0.44 -6.14 -0.32 2.38e-9 Educational attainment (years of education); LUSC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.39 6.08 0.32 3.24e-9 Menarche (age at onset); LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg16606324 chr3:10149918 C3orf24 0.64 9.26 0.45 2.48e-18 Alzheimer's disease; LUSC cis rs9517320 0.515 rs72646416 chr13:99232916 C/G cg07423050 chr13:99094983 FARP1 -0.52 -9.33 -0.45 1.54e-18 Longevity; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg13453750 chr1:205783389 SLC41A1 -0.33 -6.51 -0.34 2.82e-10 Menarche (age at onset); LUSC cis rs4285028 0.948 rs7640872 chr3:121697168 C/A cg11130432 chr3:121712080 ILDR1 -0.64 -9.79 -0.47 4.65e-20 Multiple sclerosis; LUSC cis rs7954584 0.523 rs11043280 chr12:122426643 T/C cg13699009 chr12:122356056 WDR66 0.47 7.26 0.37 2.71e-12 Mean corpuscular volume; LUSC cis rs6845621 0.901 rs9991568 chr4:18922645 A/G cg12196642 chr4:18937545 NA 0.34 6.35 0.33 6.9e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg01570182 chr17:44337453 NA -0.66 -9.86 -0.47 2.66e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs259282 0.538 rs6510273 chr19:33117884 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.68 10.09 0.48 4.65e-21 Schizophrenia; LUSC cis rs9300255 0.739 rs2337934 chr12:123745359 A/G cg05973401 chr12:123451056 ABCB9 0.52 6.49 0.33 3.19e-10 Neutrophil percentage of white cells; LUSC cis rs17433780 0.892 rs72726528 chr1:89455980 C/A cg09516651 chr1:89888402 LOC400759 0.48 7.91 0.4 3.7e-14 Carotid intima media thickness; LUSC cis rs3824867 0.676 rs7104366 chr11:47462115 G/A cg20307385 chr11:47447363 PSMC3 0.65 9.68 0.47 1.04e-19 Mean corpuscular hemoglobin; LUSC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6121246 0.529 rs6058152 chr20:30178107 G/A cg21427119 chr20:30132790 HM13 -0.43 -6.15 -0.32 2.26e-9 Mean corpuscular hemoglobin; LUSC cis rs9467773 0.967 rs6456732 chr6:26514445 T/C cg09904177 chr6:26538194 HMGN4 0.75 14.22 0.61 3.18e-36 Intelligence (multi-trait analysis); LUSC cis rs1160297 0.576 rs724860 chr2:53099406 A/G cg07782112 chr2:53107842 NA 0.43 6.98 0.36 1.59e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs8062405 0.965 rs56040780 chr16:28861881 C/T cg09754948 chr16:28834200 ATXN2L 0.41 5.9 0.31 8.9e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11155671 0.530 rs6933882 chr6:150210802 A/G cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.67e-10 Testicular germ cell tumor; LUSC cis rs9300255 0.739 rs11057210 chr12:123733799 A/G cg05973401 chr12:123451056 ABCB9 0.52 6.53 0.34 2.39e-10 Neutrophil percentage of white cells; LUSC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg15147215 chr3:52552868 STAB1 -0.32 -6.33 -0.33 7.76e-10 Electroencephalogram traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg07420484 chr1:210484920 NA 0.47 6.38 0.33 6.02e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7589342 0.745 rs11124066 chr2:106516925 T/A cg16077055 chr2:106428750 NCK2 0.35 6.64 0.34 1.29e-10 Addiction; LUSC cis rs1371867 0.846 rs1660328 chr8:101303450 A/G cg00191853 chr8:101177733 SPAG1 -0.39 -6.49 -0.33 3.19e-10 Atrioventricular conduction; LUSC cis rs651907 0.640 rs771574 chr3:101620682 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.47 6.15 0.32 2.22e-9 Colorectal cancer; LUSC cis rs7572733 0.534 rs1436131 chr2:198731230 A/C cg00792783 chr2:198669748 PLCL1 0.44 6.02 0.31 4.7e-9 Dermatomyositis; LUSC cis rs11031096 0.503 rs67065286 chr11:4105273 A/C cg08557956 chr11:4115526 RRM1 -0.47 -6.06 -0.31 3.6e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9790314 0.905 rs4518145 chr3:160950030 T/C cg03342759 chr3:160939853 NMD3 -0.52 -8.74 -0.43 1.15e-16 Morning vs. evening chronotype; LUSC trans rs1994135 0.669 rs11052747 chr12:33697913 C/G cg13010199 chr12:38710504 ALG10B 0.49 6.8 0.35 4.78e-11 Resting heart rate; LUSC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg19774624 chr17:42201019 HDAC5 0.79 12.79 0.57 9.43e-31 Total body bone mineral density; LUSC cis rs5769765 0.542 rs5770725 chr22:50256309 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.62 6.55 0.34 2.16e-10 Schizophrenia; LUSC cis rs4499344 0.556 rs259243 chr19:33144726 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.93 13.68 0.6 4e-34 Mean platelet volume; LUSC cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg04414720 chr1:150670196 GOLPH3L -0.43 -6.96 -0.36 1.86e-11 Tonsillectomy; LUSC cis rs1395 1.000 rs1659695 chr2:27406944 T/A cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.4 -6.62 -0.34 1.42e-10 Blood metabolite levels; LUSC cis rs72781680 0.848 rs2339926 chr2:24045734 C/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg03433033 chr1:76189801 ACADM -0.47 -7.04 -0.36 1.09e-11 Daytime sleep phenotypes; LUSC cis rs1065852 0.906 rs5751230 chr22:42553353 G/A cg00645731 chr22:42541494 CYP2D7P1 0.58 9.91 0.48 1.77e-20 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs9612 0.948 rs189408 chr19:44268006 T/C cg08581076 chr19:44259116 C19orf61 0.48 5.85 0.3 1.2e-8 Exhaled nitric oxide output; LUSC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.56 0.46 2.65e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs523522 1.000 rs523522 chr12:121020250 A/T cg27279351 chr12:120934652 DYNLL1 0.65 8.66 0.43 2.07e-16 High light scatter reticulocyte count; LUSC cis rs9611565 0.506 rs7364221 chr22:41650190 C/A cg03806693 chr22:41940476 POLR3H -0.57 -8.48 -0.42 7.63e-16 Vitiligo; LUSC cis rs8060686 0.641 rs75450962 chr16:68210868 C/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs739401 0.611 rs401707 chr11:3050965 T/C cg05729581 chr11:3078854 CARS -0.53 -8.17 -0.41 6.57e-15 Longevity; LUSC cis rs1358748 0.522 rs4655676 chr1:67580054 C/T cg02640540 chr1:67518911 SLC35D1 0.67 6.53 0.34 2.5e-10 Tuberculosis; LUSC cis rs7173743 0.756 rs6495339 chr15:79128272 T/C cg00540400 chr15:79124168 NA 0.35 5.99 0.31 5.29e-9 Coronary artery disease; LUSC cis rs1908814 0.516 rs10113145 chr8:11793295 A/G cg21775007 chr8:11205619 TDH 0.47 6.67 0.34 1.09e-10 Neuroticism; LUSC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg05802129 chr4:122689817 NA -0.49 -8.56 -0.42 4.31e-16 Type 2 diabetes; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs2051773 0.567 rs7130826 chr11:17037793 T/G cg15084286 chr11:17036142 PLEKHA7 0.46 5.88 0.31 9.87e-9 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01965872 chr20:33291894 TP53INP2 -0.41 -6.0 -0.31 5.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21810621 chr11:1331345 LOC255512;TOLLIP -0.47 -6.19 -0.32 1.77e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg26119090 chr2:26468346 HADHA;HADHB 0.77 9.44 0.46 6.53e-19 Gut microbiome composition (summer); LUSC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg19622623 chr12:86230825 RASSF9 -0.45 -6.4 -0.33 5.37e-10 Major depressive disorder; LUSC cis rs9311676 0.632 rs62258094 chr3:58371770 T/G cg26110898 chr3:58419937 PDHB 0.41 6.69 0.34 9.67e-11 Systemic lupus erythematosus; LUSC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg15839431 chr19:19639596 YJEFN3 0.44 6.13 0.32 2.45e-9 Tonsillectomy; LUSC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg04369109 chr6:150039330 LATS1 -0.58 -8.5 -0.42 6.24e-16 Lung cancer; LUSC cis rs7586879 0.765 rs10171663 chr2:25086431 T/C cg01884057 chr2:25150051 NA 0.39 8.18 0.41 5.87e-15 Body mass index; LUSC cis rs11676348 0.774 rs13397673 chr2:219047782 A/G cg23569941 chr2:219139048 TMBIM1;PNKD 0.38 6.26 0.32 1.18e-9 Ulcerative colitis; LUSC cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg05985134 chr18:33552581 C18orf21 0.5 6.75 0.35 6.38e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs9309473 0.607 rs1403412 chr2:73598092 T/C cg20560298 chr2:73613845 ALMS1 -0.54 -7.84 -0.39 6.02e-14 Metabolite levels; LUSC cis rs2235649 0.833 rs9933168 chr16:1848361 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.46 -6.15 -0.32 2.21e-9 Blood metabolite levels; LUSC cis rs72627509 0.904 rs17081935 chr4:57823476 C/T cg26694713 chr4:57773883 REST 0.5 5.95 0.31 6.8e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.16 0.32 2.04e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11997175 0.574 rs872489 chr8:33646401 T/C ch.8.33884649F chr8:33765107 NA 0.51 8.26 0.41 3.38e-15 Body mass index; LUSC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg00310523 chr12:86230176 RASSF9 0.46 8.5 0.42 6.35e-16 Major depressive disorder; LUSC cis rs713477 1.000 rs7148481 chr14:55909267 G/A cg13175173 chr14:55914753 NA -0.32 -6.63 -0.34 1.35e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs9462027 0.606 rs2744941 chr6:34646917 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.21 -0.32 1.53e-9 Systemic lupus erythematosus; LUSC cis rs11958404 0.932 rs72818113 chr5:157439825 G/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.83 0.35 3.98e-11 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg06784218 chr1:46089804 CCDC17 0.54 11.03 0.52 2.42e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4132509 1.000 rs4132509 chr1:243943084 A/C cg21452805 chr1:244014465 NA -0.49 -5.65 -0.3 3.47e-8 RR interval (heart rate); LUSC cis rs1728785 1.000 rs1182968 chr16:68573945 C/T cg02508848 chr16:68573721 ZFP90 -0.42 -5.75 -0.3 2.07e-8 Ulcerative colitis; LUSC cis rs6537837 0.838 rs71657105 chr1:110114122 G/A cg05049280 chr1:110155535 GNAT2 0.45 6.03 0.31 4.37e-9 Major depressive disorder; LUSC cis rs10197940 0.510 rs7557092 chr2:152423459 T/A cg19508488 chr2:152266495 RIF1 0.53 7.14 0.36 5.99e-12 Lung cancer; LUSC cis rs1348850 0.632 rs4470372 chr2:178505857 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.11 0.32 2.78e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs16866061 0.515 rs11695326 chr2:225415134 A/G cg12698349 chr2:225449008 CUL3 1.0 20.73 0.75 5.74e-62 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.24 0.41 4.06e-15 Axial length; LUSC trans rs1470506 0.507 rs55985303 chr2:77224951 G/A cg01707656 chr12:12503030 MANSC1 0.45 5.94 0.31 7.05e-9 IgG glycosylation; LUSC cis rs8060686 0.641 rs55790290 chr16:68180242 A/G cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg00631329 chr6:26305371 NA -0.46 -8.9 -0.44 3.63e-17 Educational attainment; LUSC cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg17063962 chr7:91808500 NA 0.57 8.81 0.43 7.14e-17 Breast cancer; LUSC trans rs8002861 0.781 rs9525857 chr13:44437072 T/C cg12856521 chr11:46389249 DGKZ 0.41 6.52 0.34 2.54e-10 Leprosy; LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.15 -0.32 2.24e-9 Total body bone mineral density; LUSC cis rs2404602 0.692 rs35195096 chr15:76938447 C/T cg22467129 chr15:76604101 ETFA -0.42 -6.64 -0.34 1.28e-10 Blood metabolite levels; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg24675658 chr1:53192096 ZYG11B -0.68 -11.4 -0.53 1.18e-25 Monocyte count; LUSC cis rs7568458 0.684 rs1048740 chr2:85764966 A/T cg17127132 chr2:85788382 GGCX 0.43 6.13 0.32 2.42e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12801636 0.846 rs1078457 chr11:65380124 C/T cg24147428 chr11:65409760 SIPA1 -0.6 -8.08 -0.4 1.18e-14 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.18e-10 Aortic root size; LUSC cis rs9309473 1.000 rs7572722 chr2:73724675 T/C cg20560298 chr2:73613845 ALMS1 -0.45 -6.37 -0.33 6.24e-10 Metabolite levels; LUSC cis rs7582180 0.590 rs11123828 chr2:100960918 T/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.61 -0.43 2.9e-16 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg24209194 chr3:40518798 ZNF619 0.44 5.88 0.31 1.02e-8 Renal cell carcinoma; LUSC cis rs701145 0.585 rs17817774 chr3:153779868 A/G cg17054900 chr3:154042577 DHX36 -0.55 -5.97 -0.31 5.93e-9 Coronary artery disease; LUSC cis rs9399401 0.890 rs7755109 chr6:142750392 C/T cg03128060 chr6:142623767 GPR126 -0.31 -5.74 -0.3 2.08e-8 Chronic obstructive pulmonary disease; LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.1 0.64 1.27e-39 Platelet count; LUSC cis rs2760061 0.819 rs3094913 chr1:228206980 T/C cg01973587 chr1:228161476 NA -0.4 -6.98 -0.36 1.64e-11 Diastolic blood pressure; LUSC cis rs4700695 0.719 rs1643415 chr5:65447087 T/C cg21114390 chr5:65439923 SFRS12 -0.63 -9.15 -0.45 5.7e-18 Facial morphology (factor 19); LUSC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg26597838 chr10:835615 NA -1.24 -16.72 -0.68 4.91e-46 Eosinophil percentage of granulocytes; LUSC cis rs56283067 0.847 rs56172130 chr6:44696262 G/A cg20913747 chr6:44695427 NA -0.48 -7.82 -0.39 6.86e-14 Total body bone mineral density; LUSC cis rs9467773 1.000 rs4713008 chr6:26538268 T/C cg05738196 chr6:26577821 NA 0.81 15.74 0.65 3.8e-42 Intelligence (multi-trait analysis); LUSC cis rs6442522 1.000 rs6762167 chr3:15445037 A/T cg16303742 chr3:15540471 COLQ -0.29 -5.87 -0.31 1.04e-8 Uric acid levels; LUSC cis rs7568458 0.905 rs10172544 chr2:85788270 C/A cg23752985 chr2:85803571 VAMP8 0.34 7.45 0.38 7.85e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1371867 0.875 rs1371868 chr8:101330267 C/T cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.71 0.39 1.45e-13 Obesity-related traits; LUSC cis rs12980942 0.591 rs1946613 chr19:41767785 C/T cg25627403 chr19:41769009 HNRNPUL1 0.69 7.22 0.37 3.45e-12 Coronary artery disease; LUSC cis rs35123781 1.000 rs601324 chr5:139057179 C/G cg10513866 chr5:139070639 NA 0.46 8.9 0.44 3.62e-17 Schizophrenia; LUSC cis rs1979679 0.573 rs4931087 chr12:28735091 A/C cg13890972 chr12:28721907 NA 0.42 5.96 0.31 6.56e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg08470875 chr2:26401718 FAM59B 0.73 9.29 0.45 1.97e-18 Gut microbiome composition (summer); LUSC cis rs4936323 0.504 rs10891812 chr11:115096431 T/C cg04055981 chr11:115044050 NA 0.4 7.1 0.36 7.38e-12 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs9341808 0.538 rs9443742 chr6:81016929 T/G cg08355045 chr6:80787529 NA -0.39 -6.79 -0.35 5.05e-11 Sitting height ratio; LUSC cis rs6831352 0.879 rs56222233 chr4:100069627 T/G cg13256891 chr4:100009986 ADH5 -0.5 -6.47 -0.33 3.53e-10 Alcohol dependence; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01958203 chr7:99098094 ZNF394 0.45 6.73 0.35 7.61e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8062405 1.000 rs72793811 chr16:28839392 G/A cg05966235 chr16:28915196 ATP2A1 0.33 5.77 0.3 1.79e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.08 -0.48 4.71e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1568889 0.838 rs11030229 chr11:28173634 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.72 12.46 0.56 1.59e-29 Bipolar disorder; LUSC trans rs4650994 0.525 rs2493864 chr1:178545003 A/C cg05059571 chr16:84539110 KIAA1609 -0.47 -9.1 -0.45 8.3e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg20821713 chr7:1055600 C7orf50 -0.48 -5.78 -0.3 1.76e-8 Bronchopulmonary dysplasia; LUSC cis rs9549367 0.789 rs2287244 chr13:113887173 C/G cg18105134 chr13:113819100 PROZ 0.62 9.33 0.45 1.55e-18 Platelet distribution width; LUSC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg01819759 chr13:79234251 RNF219 0.59 8.38 0.42 1.54e-15 Large artery stroke; LUSC cis rs62400317 0.762 rs72865923 chr6:44878942 T/G cg18551225 chr6:44695536 NA -0.46 -7.44 -0.38 8.7e-13 Total body bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27147807 chr6:122931281 PKIB 0.44 6.19 0.32 1.75e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg05855489 chr10:104503620 C10orf26 0.58 9.25 0.45 2.73e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17255340 0.520 rs1145912 chr6:83994757 G/C cg08257003 chr6:84140564 ME1 0.32 7.89 0.4 4.39e-14 Platelet-derived growth factor BB levels; LUSC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg05623727 chr3:50126028 RBM5 0.32 5.98 0.31 5.71e-9 Body mass index; LUSC cis rs17401966 0.522 rs6541085 chr1:10285709 A/G cg17425144 chr1:10567563 PEX14 -0.33 -5.81 -0.3 1.43e-8 Hepatocellular carcinoma; LUSC cis rs11864453 0.826 rs2240243 chr16:72137561 A/G cg23815491 chr16:72088622 HP -0.35 -6.02 -0.31 4.58e-9 Fibrinogen levels; LUSC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg10523679 chr1:76189770 ACADM 0.89 12.46 0.56 1.56e-29 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.44 6.1 0.32 2.96e-9 Multiple sclerosis; LUSC cis rs4478858 0.684 rs2050816 chr1:31721708 G/T cg00250761 chr1:31883323 NA -0.33 -8.19 -0.41 5.59e-15 Alcohol dependence; LUSC trans rs12692738 0.526 rs355858 chr2:165629457 G/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11679564 0.714 rs10490657 chr2:37178255 C/T cg14987922 chr2:37194071 STRN 0.6 8.84 0.44 5.57e-17 Immature fraction of reticulocytes; LUSC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg14440974 chr22:39074834 NA 0.38 6.24 0.32 1.32e-9 Menopause (age at onset); LUSC cis rs12801636 0.512 rs11227247 chr11:65422853 A/C cg26668713 chr11:65405903 SIPA1 0.61 6.13 0.32 2.44e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs9325144 0.647 rs12424190 chr12:39111206 A/T cg26384229 chr12:38710491 ALG10B -0.63 -9.94 -0.48 1.47e-20 Morning vs. evening chronotype; LUSC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg17971929 chr21:40555470 PSMG1 -0.64 -10.44 -0.5 2.82e-22 Cognitive function; LUSC cis rs16910800 0.953 rs77585463 chr11:23205379 T/C cg20040320 chr11:23191996 NA -0.44 -6.45 -0.33 3.85e-10 Cancer; LUSC cis rs11229555 0.645 rs12797488 chr11:58174653 A/T cg15696309 chr11:58395628 NA -0.67 -8.23 -0.41 4.39e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.15 -0.49 2.83e-21 Alzheimer's disease; LUSC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg24060327 chr5:131705240 SLC22A5 -0.4 -6.39 -0.33 5.5e-10 Blood metabolite levels; LUSC cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg16586182 chr3:47516702 SCAP 0.5 7.2 0.37 4.01e-12 Colorectal cancer; LUSC cis rs3125734 0.608 rs7094950 chr10:64019744 T/C cg19640130 chr10:64028056 RTKN2 -0.39 -7.02 -0.36 1.26e-11 Rheumatoid arthritis; LUSC cis rs7809950 0.723 rs62483633 chr7:106876644 T/G cg23024343 chr7:107201750 COG5 -0.66 -9.9 -0.48 1.98e-20 Coronary artery disease; LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg26119090 chr2:26468346 HADHA;HADHB -1.04 -15.88 -0.66 1.05e-42 Gut microbiome composition (summer); LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg11843238 chr5:131593191 PDLIM4 0.41 6.92 0.35 2.35e-11 Breast cancer; LUSC trans rs4714291 0.862 rs2984433 chr6:39973445 T/G cg02267698 chr19:7991119 CTXN1 -0.51 -7.55 -0.38 4.29e-13 Strep throat; LUSC cis rs354225 0.544 rs7340302 chr2:54803671 A/C cg26097391 chr2:54893211 SPTBN1 0.43 6.42 0.33 4.68e-10 Schizophrenia; LUSC cis rs2072499 0.865 rs2758603 chr1:156198994 T/C cg24450063 chr1:156163899 SLC25A44 1.1 22.14 0.77 1.73e-67 Testicular germ cell tumor; LUSC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg02428538 chr16:24856791 SLC5A11 0.54 6.06 0.31 3.7e-9 Intelligence (multi-trait analysis); LUSC cis rs644148 0.770 rs2571113 chr19:44999814 A/G cg15540054 chr19:45004280 ZNF180 -0.63 -9.36 -0.46 1.18e-18 Personality dimensions; LUSC cis rs782590 0.818 rs2627765 chr2:55883317 G/T cg03859395 chr2:55845619 SMEK2 0.79 13.91 0.61 5.29e-35 Metabolic syndrome; LUSC trans rs1005277 0.579 rs2749612 chr10:38488610 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -9.21 -0.45 3.82e-18 Extrinsic epigenetic age acceleration; LUSC cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg00677455 chr12:58241039 CTDSP2 -0.4 -5.85 -0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC cis rs847577 0.572 rs847573 chr7:97681761 C/T cg24562669 chr7:97807699 LMTK2 -0.36 -5.71 -0.3 2.44e-8 Breast cancer; LUSC cis rs611744 0.631 rs681963 chr8:109255032 C/A cg21045802 chr8:109455806 TTC35 0.43 6.57 0.34 1.92e-10 Dupuytren's disease; LUSC trans rs7937682 0.889 rs1784787 chr11:111486125 T/A cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs11122272 0.735 rs971534 chr1:231521971 C/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs9811920 0.928 rs2130369 chr3:99873317 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.32 5.94 0.31 7.22e-9 Axial length; LUSC trans rs6952808 1.000 rs6952808 chr7:1886535 C/G cg24247370 chr13:99142703 STK24 -0.35 -6.46 -0.33 3.62e-10 Bipolar disorder and schizophrenia; LUSC cis rs2346177 0.519 rs13003074 chr2:46671420 A/T cg02822958 chr2:46747628 ATP6V1E2 -0.46 -8.25 -0.41 3.73e-15 HDL cholesterol; LUSC cis rs881375 1.000 rs881375 chr9:123652898 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.77 0.35 5.7e-11 Rheumatoid arthritis; LUSC cis rs113835537 0.597 rs57288351 chr11:66307489 C/T cg24851651 chr11:66362959 CCS 0.53 7.77 0.39 1e-13 Airway imaging phenotypes; LUSC cis rs9650315 0.929 rs66518479 chr8:57180675 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.8 0.35 4.85e-11 Height; LUSC cis rs7011049 1.000 rs72643574 chr8:53844501 G/C cg26025543 chr8:53854495 NA 0.53 6.35 0.33 7.13e-10 Systolic blood pressure; LUSC cis rs2295359 1.000 rs736197 chr1:67607135 G/T cg12940439 chr1:67600707 NA 0.39 6.53 0.34 2.47e-10 Psoriasis; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg15242686 chr22:24348715 GSTTP1 0.53 8.26 0.41 3.49e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg19774624 chr17:42201019 HDAC5 -0.8 -13.44 -0.59 3.23e-33 Total body bone mineral density; LUSC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.37 5.85 0.3 1.18e-8 Total body bone mineral density; LUSC cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg20283391 chr11:68216788 NA -0.61 -8.45 -0.42 8.91e-16 Total body bone mineral density; LUSC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -5.88 -0.31 9.89e-9 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg25456477 chr12:86230367 RASSF9 0.4 7.2 0.37 4.03e-12 Major depressive disorder; LUSC cis rs2230307 0.572 rs11166408 chr1:100641350 A/T cg24955406 chr1:100503596 HIAT1 -0.57 -5.88 -0.31 1.01e-8 Carotid intima media thickness; LUSC cis rs11608355 0.515 rs4766605 chr12:109895636 C/A cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs7258465 0.965 rs1560118 chr19:18570035 G/A cg11102782 chr19:18549136 ISYNA1 -0.34 -6.38 -0.33 5.88e-10 Breast cancer; LUSC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg27286337 chr10:134555280 INPP5A 0.91 12.02 0.55 6.63e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs17086172 0.841 rs76001318 chr18:70271977 G/A cg02919422 chr8:55370544 SOX17 -0.74 -6.62 -0.34 1.44e-10 Airflow obstruction; LUSC cis rs554111 0.656 rs10799682 chr1:21424030 G/C cg01072550 chr1:21505969 NA 0.38 5.82 0.3 1.41e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs10193935 0.901 rs55978605 chr2:42573402 C/A cg27598129 chr2:42591480 NA -0.6 -8.24 -0.41 4.04e-15 Colonoscopy-negative controls vs population controls; LUSC trans rs9929218 0.906 rs4783571 chr16:68806778 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -11.75 -0.54 6.51e-27 Colorectal cancer; LUSC cis rs760805 1.000 rs7517302 chr1:25254317 C/T cg22509179 chr1:25234806 RUNX3 -0.6 -10.16 -0.49 2.59e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs13401104 0.796 rs10929167 chr2:237115248 G/A cg19324714 chr2:237145437 ASB18 0.43 5.88 0.31 9.94e-9 Educational attainment; LUSC cis rs1113500 0.933 rs11185261 chr1:108638703 G/A cg11967332 chr1:108735228 SLC25A24 0.39 5.92 0.31 7.96e-9 Growth-regulated protein alpha levels; LUSC cis rs9287719 0.837 rs4233883 chr2:10755596 A/G cg00105475 chr2:10696890 NA 0.36 5.94 0.31 7.35e-9 Prostate cancer; LUSC cis rs1215050 0.904 rs9307215 chr4:98813965 A/G cg05340658 chr4:99064831 C4orf37 0.41 6.25 0.32 1.28e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7804356 1.000 rs57135974 chr7:26850699 C/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg18306943 chr3:40428807 ENTPD3 0.4 6.31 0.33 8.75e-10 Renal cell carcinoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13247668 chr7:2272740 MAD1L1 -0.42 -6.25 -0.32 1.27e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13253111 0.624 rs35990565 chr8:28107815 C/T cg26534493 chr8:28060551 NA 0.37 6.9 0.35 2.56e-11 Childhood body mass index; LUSC cis rs921968 0.541 rs6710383 chr2:219359685 T/G cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg06221963 chr1:154839813 KCNN3 -0.63 -13.98 -0.61 2.74e-35 Prostate cancer; LUSC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs10986311 0.706 rs7854989 chr9:127133584 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.44 7.14 0.36 5.99e-12 Vitiligo; LUSC cis rs1172822 0.698 rs10420693 chr19:55830777 G/A cg04391588 chr19:55832610 TMEM150B 0.3 5.83 0.3 1.29e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg18252515 chr7:66147081 NA -1.22 -13.44 -0.59 3.3e-33 Diabetic kidney disease; LUSC trans rs61931739 0.517 rs1843738 chr12:34056935 C/T cg26384229 chr12:38710491 ALG10B 0.72 11.36 0.53 1.66e-25 Morning vs. evening chronotype; LUSC cis rs208515 0.556 rs1872309 chr6:66660432 A/C cg07460842 chr6:66804631 NA 0.86 11.12 0.52 1.14e-24 Exhaled nitric oxide levels; LUSC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 12.8 0.57 8.5e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7939886 0.920 rs7936219 chr11:55977335 C/T cg03929089 chr4:120376271 NA 0.83 6.2 0.32 1.71e-9 Myopia (pathological); LUSC cis rs9788682 0.948 rs905739 chr15:78845110 A/G cg18825076 chr15:78729989 IREB2 0.48 6.49 0.33 3.1e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs4947962 0.618 rs73131825 chr7:55098150 G/A cg23757825 chr7:55092271 EGFR -0.66 -8.51 -0.42 5.97e-16 Subjective response to lithium treatment; LUSC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg15649852 chr7:65879115 NA -0.41 -5.64 -0.3 3.53e-8 Aortic root size; LUSC trans rs7178375 1.000 rs1474382 chr15:31214649 A/G cg04373760 chr16:53404718 NA 0.65 8.8 0.43 7.59e-17 Hypertriglyceridemia; LUSC cis rs10189230 0.967 rs13012331 chr2:222350600 G/A cg14652038 chr2:222343519 EPHA4 0.33 5.93 0.31 7.56e-9 Urate levels in lean individuals; LUSC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg12257692 chr3:49977190 RBM6 -0.25 -7.11 -0.36 6.87e-12 Intelligence (multi-trait analysis); LUSC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 6.97e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11864453 0.611 rs1050361 chr16:72130203 C/G cg16558253 chr16:72132732 DHX38 -0.37 -5.92 -0.31 8.15e-9 Fibrinogen levels; LUSC cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg18681998 chr4:17616180 MED28 0.81 14.81 0.63 1.65e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9311676 0.618 rs12152336 chr3:58365146 T/A cg26110898 chr3:58419937 PDHB 0.44 7.22 0.37 3.62e-12 Systemic lupus erythematosus; LUSC cis rs231513 1.000 rs231519 chr17:41961051 C/T cg26893861 chr17:41843967 DUSP3 0.51 5.9 0.31 8.71e-9 Cognitive function; LUSC cis rs1691799 0.867 rs961049 chr12:66762591 A/C cg16791601 chr12:66731901 HELB 0.64 11.14 0.52 9.8e-25 White blood cell count (basophil); LUSC cis rs12893668 0.608 rs12889721 chr14:104034863 C/T cg04998671 chr14:104000505 TRMT61A -0.47 -6.66 -0.34 1.13e-10 Reticulocyte count; LUSC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg17633681 chr16:88106987 BANP 0.53 10.13 0.48 3.21e-21 Menopause (age at onset); LUSC cis rs7000551 0.663 rs11778844 chr8:22335170 C/T cg12081754 chr8:22256438 SLC39A14 0.46 6.95 0.36 1.87e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9487051 0.724 rs13200047 chr6:109633244 T/C cg01475377 chr6:109611718 NA -0.38 -5.75 -0.3 2.02e-8 Reticulocyte fraction of red cells; LUSC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg04414720 chr1:150670196 GOLPH3L 0.51 7.88 0.4 4.63e-14 Melanoma; LUSC cis rs983392 0.679 rs7930318 chr11:60033371 C/T cg20284999 chr11:59952153 MS4A6A 0.38 6.38 0.33 5.85e-10 Alzheimer's disease (late onset); LUSC cis rs10203711 1.000 rs7582256 chr2:239587446 C/T cg14580085 chr2:239553406 NA 0.42 7.02 0.36 1.25e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.66 11.5 0.53 5.02e-26 Personality dimensions; LUSC cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg23711669 chr6:146136114 FBXO30 0.88 16.22 0.66 4.78e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs56283067 0.577 rs114009236 chr6:44897517 T/C cg20913747 chr6:44695427 NA -0.48 -7.51 -0.38 5.55e-13 Total body bone mineral density; LUSC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg11062466 chr8:58055876 NA -0.7 -8.68 -0.43 1.73e-16 Developmental language disorder (linguistic errors); LUSC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9303401 0.704 rs7359501 chr17:56641200 C/T cg12560992 chr17:57184187 TRIM37 0.5 7.58 0.38 3.48e-13 Cognitive test performance; LUSC cis rs238295 0.843 rs238288 chr20:5591903 T/G cg15842884 chr20:5591925 RP5-1022P6.2 -0.48 -6.82 -0.35 4.39e-11 Occipital cortical area (total cortical area interaction); LUSC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg24060327 chr5:131705240 SLC22A5 0.46 7.96 0.4 2.72e-14 Blood metabolite levels; LUSC cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.34 -0.42 1.98e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9341835 0.772 rs9294202 chr6:64138954 A/G cg03326410 chr6:64151739 NA -0.37 -6.16 -0.32 2.11e-9 Schizophrenia; LUSC cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg14530993 chr4:882597 GAK 0.73 7.54 0.38 4.37e-13 Intelligence (multi-trait analysis); LUSC trans rs4927850 1.000 rs7627706 chr3:195753353 A/C cg16724585 chr3:197361211 NA -0.62 -8.77 -0.43 9.17e-17 Pancreatic cancer; LUSC cis rs6840360 0.615 rs1561917 chr4:152479233 G/A cg22705602 chr4:152727874 NA -0.32 -6.38 -0.33 6.04e-10 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1113500 0.933 rs61797344 chr1:108622580 C/T cg06207961 chr1:108661230 NA 0.42 7.72 0.39 1.37e-13 Growth-regulated protein alpha levels; LUSC cis rs6977660 0.660 rs61670426 chr7:19790460 A/G cg07541023 chr7:19748670 TWISTNB 0.67 7.16 0.36 5.25e-12 Thyroid stimulating hormone; LUSC cis rs1882538 0.569 rs11562037 chr7:133076885 A/G cg10665199 chr7:133106180 EXOC4 0.55 7.78 0.39 9.12e-14 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs2259928 chr20:25281834 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.22 0.88 3.18e-111 Chronic sinus infection; LUSC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg18230493 chr5:56204884 C5orf35 -0.59 -9.29 -0.45 2.07e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs9677476 0.863 rs10187005 chr2:232077948 C/T cg07929768 chr2:232055508 NA 0.36 6.9 0.35 2.68e-11 Food antigen IgG levels; LUSC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.69 -0.34 9.34e-11 Lung cancer; LUSC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg07777115 chr5:623756 CEP72 -0.47 -5.97 -0.31 5.94e-9 Obesity-related traits; LUSC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg09877947 chr5:131593287 PDLIM4 0.43 7.24 0.37 3.2e-12 Blood metabolite levels; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg19857457 chr18:47018947 RPL17;SNORD58A;SNORD58B 0.33 6.39 0.33 5.7e-10 Tuberculosis; LUSC cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.67 -0.34 1.05e-10 Monocyte percentage of white cells; LUSC cis rs10097731 0.901 rs28505206 chr8:82044410 A/G cg25230327 chr8:82042993 NA -0.48 -6.96 -0.36 1.77e-11 Serum total protein level; LUSC cis rs524023 0.756 rs576076 chr11:64360623 G/A cg19131476 chr11:64387923 NRXN2 0.35 8.12 0.41 9.04e-15 Urate levels in obese individuals; LUSC cis rs208520 0.690 rs2208442 chr6:66867004 T/C cg07460842 chr6:66804631 NA -1.14 -17.9 -0.7 1.07e-50 Exhaled nitric oxide output; LUSC cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg25173405 chr17:45401733 C17orf57 -0.36 -5.69 -0.3 2.85e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2742417 1.000 rs2742418 chr3:45731920 C/T cg09608765 chr3:45636137 LIMD1 -0.37 -7.21 -0.37 3.68e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg01579765 chr21:45077557 HSF2BP -0.55 -11.91 -0.55 1.73e-27 Mean corpuscular volume; LUSC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg26513180 chr16:89883248 FANCA 0.9 17.67 0.7 8.3e-50 Vitiligo; LUSC cis rs10743315 0.643 rs7962924 chr12:19341989 G/A cg02471346 chr12:19282374 PLEKHA5 0.63 6.02 0.31 4.59e-9 Gut microbiota (bacterial taxa); LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg11871910 chr12:69753446 YEATS4 0.95 17.8 0.7 2.59e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs17253792 0.915 rs74580958 chr14:56181511 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.87 -0.35 3.09e-11 Putamen volume; LUSC cis rs73193808 0.639 rs2832241 chr21:30552036 A/G cg03476357 chr21:30257390 N6AMT1 0.44 5.9 0.31 8.88e-9 Coronary artery disease; LUSC trans rs7618501 0.633 rs13060128 chr3:50025028 A/G cg21659725 chr3:3221576 CRBN 0.63 10.24 0.49 1.43e-21 Intelligence (multi-trait analysis); LUSC cis rs9807989 0.801 rs6734742 chr2:102967857 C/T cg03938978 chr2:103052716 IL18RAP 0.32 5.9 0.31 9.04e-9 Asthma; LUSC cis rs524023 0.874 rs518053 chr11:64456099 C/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.5 -0.5 1.75e-22 Urate levels in obese individuals; LUSC cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg16006841 chr5:176797999 RGS14 -0.62 -9.98 -0.48 1.09e-20 Hemoglobin concentration;Hematocrit; LUSC trans rs9388451 0.513 rs1268069 chr6:126039994 A/C cg05039488 chr6:79577232 IRAK1BP1 -0.71 -11.84 -0.54 3.15e-27 Brugada syndrome; LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9341808 0.538 rs9343980 chr6:81023432 A/G cg08355045 chr6:80787529 NA -0.4 -6.92 -0.35 2.38e-11 Sitting height ratio; LUSC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg00033643 chr7:134001901 SLC35B4 0.46 7.09 0.36 7.83e-12 Mean platelet volume; LUSC cis rs4629710 0.592 rs35017713 chr6:131581212 G/A cg12606694 chr6:131520996 AKAP7 0.63 9.56 0.46 2.57e-19 Multiple myeloma (IgH translocation); LUSC cis rs6754311 0.731 rs309160 chr2:136685228 C/T cg07169764 chr2:136633963 MCM6 0.52 7.2 0.37 4.1e-12 Mosquito bite size; LUSC cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg00071950 chr4:10020882 SLC2A9 -0.51 -8.45 -0.42 9.36e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11971779 0.774 rs6467838 chr7:139043501 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg26441486 chr22:50317300 CRELD2 0.48 7.15 0.36 5.35e-12 Schizophrenia; LUSC cis rs4478858 0.684 rs7519766 chr1:31735512 C/A cg00250761 chr1:31883323 NA -0.33 -7.91 -0.4 3.81e-14 Alcohol dependence; LUSC cis rs34421088 0.506 rs2409755 chr8:11169983 G/A cg27411982 chr8:10470053 RP1L1 0.36 5.67 0.3 3.15e-8 Neuroticism; LUSC cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg10172584 chr19:19639581 YJEFN3 -0.49 -5.78 -0.3 1.75e-8 Bipolar disorder; LUSC cis rs765787 0.530 rs4775831 chr15:45534722 A/C cg25801113 chr15:45476975 SHF 0.35 7.17 0.37 4.84e-12 Uric acid levels; LUSC cis rs7091068 0.671 rs591392 chr10:95406081 G/A cg20715218 chr10:95462985 C10orf4 -0.61 -7.16 -0.36 5.29e-12 Urinary tract infection frequency; LUSC cis rs77633900 0.772 rs2957613 chr15:76700589 C/T cg21673338 chr15:77095150 SCAPER -0.7 -5.97 -0.31 6.14e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs7586879 0.828 rs1077641 chr2:25123665 G/A cg01884057 chr2:25150051 NA 0.42 8.8 0.43 7.49e-17 Body mass index; LUSC cis rs73198271 1.000 rs11775821 chr8:8609153 A/G cg01851573 chr8:8652454 MFHAS1 0.58 8.01 0.4 1.9e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg08773314 chr2:239334832 ASB1 0.42 8.99 0.44 1.93e-17 Multiple system atrophy; LUSC cis rs2273669 0.667 rs76747161 chr6:109305456 G/A cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs12802244 1 rs12802244 chr11:47932666 G/A cg05585544 chr11:47624801 NA -0.37 -6.47 -0.33 3.53e-10 Neuroticism; LUSC cis rs7267979 1.000 rs4815404 chr20:25301845 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.09 -0.74 2.1e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg13206674 chr6:150067644 NUP43 0.51 7.76 0.39 1.08e-13 Lung cancer; LUSC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg21724239 chr8:58056113 NA 0.55 6.25 0.32 1.24e-9 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg08470875 chr2:26401718 FAM59B -0.66 -8.76 -0.43 1.02e-16 Gut microbiome composition (summer); LUSC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg21963583 chr11:68658836 MRPL21 0.59 8.76 0.43 9.71e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7614311 0.681 rs6809100 chr3:63901180 A/G cg22134162 chr3:63841271 THOC7 -0.47 -5.93 -0.31 7.72e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs713587 0.806 rs6737082 chr2:25138040 A/C cg01884057 chr2:25150051 NA 0.44 10.42 0.5 3.42e-22 Body mass index in non-asthmatics; LUSC cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg22782873 chr19:19639568 YJEFN3 -0.53 -6.5 -0.34 2.92e-10 Bipolar disorder; LUSC cis rs9388451 0.874 rs7739566 chr6:126094757 A/T cg10911889 chr6:126070802 HEY2 0.42 6.39 0.33 5.41e-10 Brugada syndrome; LUSC cis rs73198271 1.000 rs11776513 chr8:8609057 T/C cg01851573 chr8:8652454 MFHAS1 0.58 8.01 0.4 1.9e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs929354 0.742 rs886677 chr7:157003782 T/A cg17757837 chr7:157058334 UBE3C 0.82 13.21 0.59 2.34e-32 Body mass index; LUSC cis rs11098499 0.754 rs11724409 chr4:120252361 A/G cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs2562152 0.613 rs216599 chr16:109671 A/G cg02949481 chr16:131562 MPG 0.48 5.76 0.3 1.89e-8 Glioblastoma; LUSC cis rs7575217 0.740 rs12468712 chr2:101746066 A/T cg23907051 chr2:101730305 TBC1D8 -0.28 -7.39 -0.37 1.17e-12 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs4319547 0.910 rs6416298 chr12:123002143 C/T cg23029597 chr12:123009494 RSRC2 -0.73 -9.33 -0.45 1.47e-18 Body mass index; LUSC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC cis rs12476592 0.571 rs166384 chr2:63863630 G/T cg10828910 chr2:63850056 LOC388955 0.49 5.78 0.3 1.71e-8 Childhood ear infection; LUSC cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.03 0.44 1.43e-17 Motion sickness; LUSC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.79 -14.23 -0.61 2.9e-36 Total body bone mineral density; LUSC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.81 15.17 0.64 6.84e-40 Total body bone mineral density; LUSC cis rs1395 0.744 rs11126931 chr2:27474306 C/T cg23587288 chr2:27483067 SLC30A3 -0.29 -5.74 -0.3 2.17e-8 Blood metabolite levels; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.86 -11.92 -0.55 1.56e-27 Platelet count; LUSC cis rs1775715 0.737 rs2799018 chr10:32202069 C/T cg26784012 chr10:32216390 ARHGAP12 0.47 7.94 0.4 3.05e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs921968 0.541 rs58650092 chr2:219304851 C/A cg02176678 chr2:219576539 TTLL4 -0.71 -13.33 -0.59 8.65e-33 Mean corpuscular hemoglobin concentration; LUSC cis rs7937682 0.883 rs12366001 chr11:111433916 A/G cg11344533 chr11:111475393 SIK2 0.47 6.28 0.33 1.03e-9 Primary sclerosing cholangitis; LUSC cis rs9303401 0.625 rs66508449 chr17:56691034 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.84 0.6 9.65e-35 Cognitive test performance; LUSC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg17366294 chr4:99064904 C4orf37 0.54 8.93 0.44 2.96e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.11e-14 Glomerular filtration rate (creatinine); LUSC cis rs7937682 0.575 rs7950926 chr11:111776437 G/C cg19812747 chr11:111475976 SIK2 0.41 5.66 0.3 3.23e-8 Primary sclerosing cholangitis; LUSC cis rs17253792 0.822 rs28681420 chr14:56088403 G/T cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg02389323 chr16:88786976 FAM38A 1.28 11.61 0.54 2.03e-26 Plateletcrit; LUSC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg00684032 chr4:1343700 KIAA1530 0.44 7.74 0.39 1.17e-13 Obesity-related traits; LUSC cis rs9391997 0.567 rs4256472 chr6:434915 A/G cg09757644 chr6:447497 NA -0.27 -5.72 -0.3 2.33e-8 Chronic lymphocytic leukemia; LUSC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg19346786 chr7:2764209 NA -0.46 -7.93 -0.4 3.32e-14 Height; LUSC cis rs644799 0.601 rs7902 chr11:95565288 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.73 11.38 0.53 1.36e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg26597838 chr10:835615 NA 0.97 13.35 0.59 7.23e-33 Eosinophil percentage of granulocytes; LUSC cis rs28647808 0.881 rs4962047 chr9:136262916 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC trans rs7395662 0.517 rs10838960 chr11:48584741 A/G cg15704280 chr7:45808275 SEPT13 -0.45 -6.23 -0.32 1.38e-9 HDL cholesterol; LUSC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg07777115 chr5:623756 CEP72 -0.47 -5.77 -0.3 1.78e-8 Lung disease severity in cystic fibrosis; LUSC trans rs12677056 0.651 rs62514387 chr8:113283969 C/T cg12159992 chr12:102059490 MYBPC1 0.37 6.19 0.32 1.72e-9 Peripheral artery disease; LUSC cis rs9457247 0.582 rs9459855 chr6:167466150 G/T cg25258033 chr6:167368657 RNASET2 0.44 6.61 0.34 1.53e-10 Crohn's disease; LUSC trans rs9380880 0.826 rs12175102 chr6:39554898 C/T cg14673904 chr12:46609063 SLC38A1 -0.52 -5.98 -0.31 5.58e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs513349 1.000 rs210145 chr6:33547440 G/C cg24505687 chr6:33548425 BAK1 0.37 6.18 0.32 1.88e-9 Platelet count; LUSC trans rs561341 0.769 rs559228 chr17:30294527 T/C cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs765787 0.530 rs11070445 chr15:45513163 T/A cg25801113 chr15:45476975 SHF -0.34 -6.71 -0.34 8.19e-11 Uric acid levels; LUSC cis rs3820068 0.608 rs12091326 chr1:16048005 A/G cg13390004 chr1:15929781 NA 0.4 6.48 0.33 3.3e-10 Systolic blood pressure; LUSC cis rs3755132 0.929 rs61446904 chr2:15748873 A/C cg12888861 chr2:15731646 DDX1 0.5 7.3 0.37 2.16e-12 Wilms tumor; LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg20887711 chr4:1340912 KIAA1530 0.44 6.61 0.34 1.48e-10 Obesity-related traits; LUSC cis rs10761482 0.500 rs1890926 chr10:62290105 T/C cg18175470 chr10:62150864 ANK3 -0.48 -7.22 -0.37 3.47e-12 Schizophrenia; LUSC cis rs7715806 0.500 rs4704233 chr5:75000792 G/A cg19683494 chr5:74908142 NA 0.56 7.63 0.39 2.54e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg16362232 chr11:430036 ANO9 0.7 8.64 0.43 2.3e-16 Body mass index; LUSC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg26597838 chr10:835615 NA 0.74 9.26 0.45 2.62e-18 Eosinophil percentage of granulocytes; LUSC cis rs7017697 1.000 rs6980875 chr8:19685948 C/T cg03894339 chr8:19674705 INTS10 -0.47 -6.83 -0.35 4.14e-11 Breast cancer; LUSC trans rs1994135 0.715 rs10844625 chr12:33693006 C/T cg26384229 chr12:38710491 ALG10B 0.61 8.46 0.42 8.24e-16 Resting heart rate; LUSC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg10295955 chr4:187884368 NA 0.74 11.27 0.52 3.4e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs394563 0.901 rs448874 chr6:149796967 C/T cg07828024 chr6:149772892 ZC3H12D -0.32 -7.04 -0.36 1.1e-11 Dupuytren's disease; LUSC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -6.97 -0.36 1.67e-11 Intelligence (multi-trait analysis); LUSC trans rs4729127 1.000 rs4729122 chr7:93988850 T/C cg20086523 chr13:52378287 DHRS12 0.57 6.12 0.32 2.64e-9 Intelligence; LUSC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg25019033 chr10:957182 NA -0.51 -6.49 -0.33 3.03e-10 Eosinophil percentage of granulocytes; LUSC cis rs7267979 1.000 rs2257496 chr20:25279315 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9951602 0.573 rs78623099 chr18:76646228 G/T cg02800362 chr5:177631904 HNRNPAB 0.85 12.77 0.57 1.09e-30 Obesity-related traits; LUSC cis rs7147624 1.000 rs1009465 chr14:65970370 G/C cg03016385 chr14:66212404 NA -0.81 -9.47 -0.46 5.1e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg18240062 chr17:79603768 NPLOC4 0.64 11.34 0.53 1.91e-25 Eye color traits; LUSC cis rs295140 0.632 rs4673905 chr2:201163783 A/G cg04283868 chr2:201171347 SPATS2L 0.4 5.78 0.3 1.75e-8 QT interval; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03791497 chr17:21118194 TMEM11 -0.47 -6.42 -0.33 4.77e-10 Hepatitis; LUSC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg08859206 chr1:53392774 SCP2 -0.41 -6.72 -0.35 7.81e-11 Monocyte count; LUSC cis rs751728 0.626 rs57150921 chr6:33737518 T/C cg25922239 chr6:33757077 LEMD2 0.45 6.69 0.34 9.64e-11 Crohn's disease; LUSC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.9 -15.7 -0.65 5.27e-42 Chronic sinus infection; LUSC cis rs2439831 0.867 rs6493085 chr15:43654182 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs12541491 0.506 rs11250007 chr8:10285086 C/G cg12940923 chr8:10282607 MSRA -0.47 -8.11 -0.41 9.76e-15 Schizophrenia; LUSC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg04317338 chr11:64019027 PLCB3 0.68 7.75 0.39 1.12e-13 Mean platelet volume; LUSC cis rs12594515 1.000 rs8032361 chr15:45988553 T/C cg06207120 chr15:45996521 NA 0.39 6.09 0.32 3.08e-9 Waist circumference;Weight; LUSC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg22875332 chr1:76189707 ACADM 0.84 13.87 0.6 7.24e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6987853 0.814 rs2923447 chr8:42439848 G/T cg09913449 chr8:42400586 C8orf40 0.5 8.67 0.43 1.87e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs7937682 1.000 rs7121011 chr11:111568681 C/T cg22437258 chr11:111473054 SIK2 -0.48 -6.24 -0.32 1.33e-9 Primary sclerosing cholangitis; LUSC trans rs7395662 0.591 rs11039776 chr11:48516706 G/A cg15704280 chr7:45808275 SEPT13 -0.44 -6.1 -0.32 3e-9 HDL cholesterol; LUSC cis rs7312933 0.584 rs6582395 chr12:42700141 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.81 0.35 4.63e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg07157834 chr1:205819609 PM20D1 0.89 16.47 0.67 5.01e-45 Menarche (age at onset); LUSC cis rs9359856 0.564 rs72913954 chr6:90361589 T/C cg13799429 chr6:90582589 CASP8AP2 -0.9 -8.76 -0.43 1e-16 Bipolar disorder; LUSC cis rs4664308 0.935 rs6739867 chr2:160942818 G/A cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs727505 0.954 rs7789055 chr7:124677543 G/T cg23710748 chr7:124431027 NA -0.38 -6.79 -0.35 5.21e-11 Lewy body disease; LUSC cis rs11997175 0.624 rs67643247 chr8:33700790 G/A ch.8.33884649F chr8:33765107 NA 0.44 6.19 0.32 1.72e-9 Body mass index; LUSC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg08508325 chr11:3079039 CARS -0.49 -11.87 -0.54 2.37e-27 Longevity; LUSC cis rs6961069 0.722 rs4626520 chr7:80260023 G/A cg04458919 chr7:80252533 CD36 0.38 6.7 0.34 8.83e-11 Platelet count; LUSC cis rs79349575 0.778 rs12950328 chr17:46967061 C/T cg22482690 chr17:47019901 SNF8 0.4 7.47 0.38 7e-13 Type 2 diabetes; LUSC cis rs6977660 0.714 rs6943204 chr7:19818671 A/G cg05791153 chr7:19748676 TWISTNB 0.65 7.0 0.36 1.44e-11 Thyroid stimulating hormone; LUSC trans rs17685 0.712 rs59659102 chr7:75710114 G/A cg19862616 chr7:65841803 NCRNA00174 1.11 19.05 0.72 2.85e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1524927 1.000 rs7805658 chr7:96328466 G/A cg03808172 chr7:96339361 SHFM1 0.43 6.54 0.34 2.32e-10 Total body bone mineral density; LUSC cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg27279351 chr12:120934652 DYNLL1 0.62 8.23 0.41 4.34e-15 High light scatter reticulocyte count; LUSC cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.73e-30 Motion sickness; LUSC cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.84 0.51 1.21e-23 Heart rate; LUSC cis rs8060686 0.545 rs12598630 chr16:68258852 T/G cg09835421 chr16:68378352 PRMT7 -0.59 -6.34 -0.33 7.28e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs17092148 1.000 rs6060047 chr20:33367400 G/T cg16810054 chr20:33298113 TP53INP2 0.42 6.13 0.32 2.45e-9 Neuroticism; LUSC cis rs10464366 0.746 rs4723822 chr7:39141613 C/T cg15212455 chr7:39170539 POU6F2 0.6 9.6 0.46 2.02e-19 IgG glycosylation; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg07211384 chr2:86668246 KDM3A 0.5 7.61 0.38 2.86e-13 Calcium levels; LUSC cis rs500891 0.574 rs3798889 chr6:84121512 G/T cg08257003 chr6:84140564 ME1 0.36 8.73 0.43 1.23e-16 Platelet-derived growth factor BB levels; LUSC trans rs7937682 1.000 rs4936661 chr11:111587495 G/A cg18187862 chr3:45730750 SACM1L -0.59 -7.2 -0.37 4.1e-12 Primary sclerosing cholangitis; LUSC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg01570182 chr17:44337453 NA -0.66 -9.9 -0.48 1.94e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg17385448 chr1:15911702 AGMAT 0.37 6.17 0.32 2.03e-9 Systolic blood pressure; LUSC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg18240062 chr17:79603768 NPLOC4 0.79 15.37 0.64 1.1e-40 Eye color traits; LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg24675658 chr1:53192096 ZYG11B -0.69 -11.31 -0.53 2.47e-25 Monocyte count; LUSC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg12310025 chr6:25882481 NA -0.58 -9.96 -0.48 1.21e-20 Blood metabolite levels; LUSC cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg07606381 chr6:8435919 SLC35B3 0.75 12.78 0.57 1.01e-30 Motion sickness; LUSC trans rs61931739 0.500 rs7310237 chr12:34483435 G/A cg13010199 chr12:38710504 ALG10B 0.58 9.16 0.45 5.51e-18 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg14582100 chr15:45693742 SPATA5L1 -0.58 -10.55 -0.5 1.19e-22 Homoarginine levels; LUSC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg13206674 chr6:150067644 NUP43 0.59 9.19 0.45 4.18e-18 Lung cancer; LUSC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg02380750 chr20:61661411 NA 0.33 5.73 0.3 2.23e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs11608355 1.000 rs10850135 chr12:109866528 C/A cg05360138 chr12:110035743 NA 0.46 6.28 0.32 1.07e-9 Neuroticism; LUSC cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC trans rs7615952 0.673 rs115942855 chr3:125601960 G/A cg07211511 chr3:129823064 LOC729375 -1.09 -12.34 -0.56 4.43e-29 Blood pressure (smoking interaction); LUSC trans rs11098499 0.820 rs13122709 chr4:120555356 T/A cg25214090 chr10:38739885 LOC399744 0.52 7.7 0.39 1.61e-13 Corneal astigmatism; LUSC cis rs244293 0.965 rs244290 chr17:53231231 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.4 -5.71 -0.3 2.52e-8 Menarche (age at onset); LUSC cis rs7843479 0.509 rs899428 chr8:21770763 T/C cg17168535 chr8:21777572 XPO7 0.69 11.81 0.54 3.76e-27 Mean corpuscular volume; LUSC cis rs73206853 0.841 rs56017468 chr12:110653857 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 6.45 0.33 3.99e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg27572855 chr1:25598939 RHD 0.46 8.29 0.41 2.81e-15 Erythrocyte sedimentation rate; LUSC cis rs208520 0.802 rs208499 chr6:66932146 C/T cg07460842 chr6:66804631 NA -1.0 -14.14 -0.61 6.61e-36 Exhaled nitric oxide output; LUSC trans rs62103177 0.810 rs62103194 chr18:77629482 G/A cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs7215564 0.908 rs57778244 chr17:78653798 T/G cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs4727027 0.704 rs13221837 chr7:148903597 C/T cg23583168 chr7:148888333 NA -0.89 -17.36 -0.69 1.5e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.98 0.44 1.99e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs17270561 0.609 rs9358876 chr6:25738956 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.27e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7592578 0.766 rs12472081 chr2:191398545 G/A cg11845111 chr2:191398756 TMEM194B -0.91 -10.73 -0.51 2.84e-23 Diastolic blood pressure; LUSC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC cis rs4888262 0.526 rs7193423 chr16:74626340 A/C cg01733217 chr16:74700730 RFWD3 0.79 13.23 0.59 2.03e-32 Testicular germ cell tumor; LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs11190604 1.000 rs2495751 chr10:102327260 A/G cg16342193 chr10:102329863 NA -0.37 -6.41 -0.33 4.83e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1577917 1.000 rs12192992 chr6:86609915 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs7712401 0.623 rs26372 chr5:122206447 C/T cg19077854 chr5:122220652 SNX24 -0.4 -8.57 -0.42 3.89e-16 Mean platelet volume; LUSC cis rs3812831 0.695 rs7983872 chr13:114944781 T/G cg08824895 chr13:115047677 UPF3A 0.56 8.63 0.43 2.48e-16 Schizophrenia; LUSC cis rs6938 0.534 rs11854704 chr15:75221015 C/T cg09165964 chr15:75287851 SCAMP5 0.51 7.54 0.38 4.35e-13 Breast cancer; LUSC cis rs709400 1.000 rs7150141 chr14:104129352 G/A cg24130564 chr14:104152367 KLC1 -0.52 -7.72 -0.39 1.35e-13 Body mass index; LUSC trans rs877282 0.838 rs11253374 chr10:774961 C/T cg22713356 chr15:30763199 NA 1.07 14.98 0.63 3.58e-39 Uric acid levels; LUSC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Urate levels; LUSC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC trans rs62103177 0.525 rs1835410 chr18:77702025 T/C cg14227996 chr4:17616232 MED28 -0.6 -6.42 -0.33 4.59e-10 Opioid sensitivity; LUSC trans rs9393777 0.920 rs35120058 chr6:27358166 A/G cg06606381 chr12:133084897 FBRSL1 -0.99 -8.82 -0.43 6.37e-17 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs4919464 chr10:102221195 A/G cg16342193 chr10:102329863 NA -0.35 -6.39 -0.33 5.63e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9296092 0.538 rs34222093 chr6:33519584 G/C cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg09267113 chr7:98030324 BAIAP2L1 0.38 5.83 0.3 1.3e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg17971929 chr21:40555470 PSMG1 -0.53 -7.77 -0.39 9.69e-14 Menarche (age at onset); LUSC cis rs11971779 0.680 rs6962637 chr7:139051350 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs3820928 0.605 rs7560867 chr2:227780945 C/A cg11843606 chr2:227700838 RHBDD1 -0.64 -10.05 -0.48 6.33e-21 Pulmonary function; LUSC cis rs7586879 0.828 rs10184813 chr2:25090236 T/C cg01884057 chr2:25150051 NA 0.4 8.18 0.41 5.86e-15 Body mass index; LUSC cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg11608241 chr8:8085544 FLJ10661 0.43 6.07 0.32 3.43e-9 Neuroticism; LUSC cis rs17094222 0.504 rs12267029 chr10:102458677 C/A cg26540559 chr10:102447443 NA 0.53 9.17 0.45 4.98e-18 Body mass index;BMI (adjusted for smoking behaviour);Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7954584 0.635 rs3847694 chr12:122325820 A/G cg21016266 chr12:122356598 WDR66 0.57 8.64 0.43 2.41e-16 Mean corpuscular volume; LUSC cis rs17270561 0.636 rs9393671 chr6:25789189 G/C cg17691542 chr6:26056736 HIST1H1C -0.46 -6.56 -0.34 2.02e-10 Iron status biomarkers; LUSC cis rs5769707 0.967 rs8141807 chr22:50043738 C/G cg20744362 chr22:50050164 C22orf34 0.41 8.39 0.42 1.4e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg12064134 chr16:90016061 DEF8 0.36 5.7 0.3 2.69e-8 Squamous cell carcinoma; LUSC cis rs295140 0.605 rs3769471 chr2:201195403 G/A cg23649088 chr2:200775458 C2orf69 -0.37 -5.67 -0.3 3.15e-8 QT interval; LUSC trans rs7826238 0.524 rs2921055 chr8:8319342 C/A cg21775007 chr8:11205619 TDH 0.41 6.0 0.31 5.1e-9 Systolic blood pressure; LUSC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg14895029 chr7:2775587 GNA12 -0.41 -6.07 -0.32 3.41e-9 Height; LUSC cis rs7146395 1 rs7146395 chr14:75228647 A/C cg08847533 chr14:75593920 NEK9 0.42 5.88 0.31 9.78e-9 Platelet count; LUSC cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg23711669 chr6:146136114 FBXO30 0.88 16.1 0.66 1.48e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.720 rs6672735 chr1:152981086 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.82 -0.39 6.89e-14 Inflammatory skin disease; LUSC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.77 -0.43 9.05e-17 Bipolar disorder; LUSC cis rs6084875 0.785 rs2050370 chr20:4719781 G/T cg26097573 chr20:4721490 PRNT -0.31 -5.67 -0.3 3.11e-8 Systemic lupus erythematosus; LUSC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11644478 chr21:40555479 PSMG1 0.89 17.19 0.69 6.71e-48 Cognitive function; LUSC trans rs7824557 0.527 rs2736298 chr8:11235136 C/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.49 -0.38 6.11e-13 Retinal vascular caliber; LUSC trans rs7824557 0.564 rs4631424 chr8:11236809 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.5 -0.34 2.9e-10 Retinal vascular caliber; LUSC trans rs7618314 0.504 rs2715694 chr3:108541143 C/T cg12062537 chr1:1496856 SSU72 -0.57 -6.03 -0.31 4.35e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs59104589 0.583 rs3771573 chr2:242387346 G/A cg14842376 chr2:242211374 HDLBP 0.53 6.15 0.32 2.2e-9 Fibrinogen levels; LUSC cis rs6138458 1.000 rs227632 chr20:24913729 G/A cg06937882 chr20:24974362 C20orf3 -0.43 -7.36 -0.37 1.42e-12 Blood protein levels; LUSC cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg03146154 chr1:46216737 IPP -0.5 -7.23 -0.37 3.29e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg08017634 chr8:144659831 NAPRT1 -0.78 -9.21 -0.45 3.72e-18 Attention deficit hyperactivity disorder; LUSC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.16 0.32 2.14e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6681460 0.966 rs6588215 chr1:67141949 A/G cg02459107 chr1:67143332 SGIP1 0.48 8.87 0.44 4.54e-17 Presence of antiphospholipid antibodies; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17440077 chr20:18122816 PET117;CSRP2BP -0.73 -6.04 -0.31 4.09e-9 Cognitive performance; LUSC cis rs7264396 0.563 rs2425116 chr20:34323553 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.38 -0.42 1.49e-15 Total cholesterol levels; LUSC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.92 -0.48 1.7e-20 Urinary metabolites; LUSC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg14019146 chr3:50243930 SLC38A3 -0.32 -7.12 -0.36 6.49e-12 Intelligence (multi-trait analysis); LUSC trans rs7613875 0.580 rs2624819 chr3:50010571 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.48 7.49 0.38 6.34e-13 Body mass index; LUSC cis rs909341 0.716 rs71325464 chr20:62363453 A/G cg09650180 chr20:62225654 GMEB2 -0.47 -6.11 -0.32 2.75e-9 Atopic dermatitis; LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg20503657 chr10:835505 NA 0.97 13.15 0.58 3.92e-32 Eosinophil percentage of granulocytes; LUSC cis rs1215050 0.791 rs10856931 chr4:98819306 C/T cg05340658 chr4:99064831 C4orf37 0.43 6.83 0.35 4.08e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9348721 0.673 rs9358934 chr6:26363755 G/C cg09904177 chr6:26538194 HMGN4 -0.71 -6.8 -0.35 4.92e-11 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs6545883 0.895 rs6545871 chr2:61692203 G/T cg15711740 chr2:61764176 XPO1 -0.45 -6.91 -0.35 2.46e-11 Tuberculosis; LUSC cis rs4561483 0.549 rs154149 chr16:11956118 T/A cg08843971 chr16:11963173 GSPT1 -0.43 -6.6 -0.34 1.64e-10 Testicular germ cell tumor; LUSC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg03929089 chr4:120376271 NA -1.03 -20.05 -0.74 3.02e-59 Height; LUSC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg13798780 chr7:105162888 PUS7 0.56 6.07 0.32 3.43e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg20887711 chr4:1340912 KIAA1530 0.46 7.19 0.37 4.23e-12 Longevity; LUSC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg23630131 chr7:65973040 NA 0.22 5.99 0.31 5.5e-9 Aortic root size; LUSC trans rs4843747 0.671 rs9921236 chr16:88117015 G/T cg26811252 chr16:29126840 RRN3P2 0.59 9.83 0.47 3.47e-20 Menopause (age at onset); LUSC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg06850241 chr22:41845214 NA 0.34 6.22 0.32 1.46e-9 Vitiligo; LUSC cis rs7113850 0.541 rs11820983 chr11:24211705 T/C ch.11.24196551F chr11:24239977 NA 0.93 7.86 0.39 5.41e-14 Bone fracture in osteoporosis; LUSC cis rs12368653 0.651 rs2307097 chr12:58195801 T/C cg12615879 chr12:58013172 SLC26A10 0.37 8.37 0.42 1.64e-15 Multiple sclerosis; LUSC cis rs17270561 0.609 rs4712963 chr6:25740502 C/T cg16482183 chr6:26056742 HIST1H1C 0.61 8.7 0.43 1.57e-16 Iron status biomarkers; LUSC cis rs3931020 0.688 rs277375 chr1:75204143 A/G cg21535942 chr1:75199100 CRYZ;TYW3 0.44 5.73 0.3 2.3e-8 Resistin levels; LUSC cis rs782590 0.683 rs782633 chr2:55898203 A/G cg03859395 chr2:55845619 SMEK2 0.86 15.72 0.65 4.52e-42 Metabolic syndrome; LUSC cis rs11785693 0.862 rs11782556 chr8:5002389 C/G cg26367366 chr8:4980734 NA 0.73 8.36 0.42 1.71e-15 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg00310523 chr12:86230176 RASSF9 0.51 9.68 0.47 1.07e-19 Major depressive disorder; LUSC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs790123 0.565 rs17269087 chr3:122379262 A/C cg00926285 chr3:122398533 PARP14 -0.48 -6.16 -0.32 2.1e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg13256891 chr4:100009986 ADH5 0.44 6.62 0.34 1.43e-10 Alcohol dependence; LUSC cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.33 5.97 0.31 6.08e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1535500 0.905 rs2146262 chr6:39283793 C/T cg06347083 chr6:39282316 KCNK17 -0.27 -6.11 -0.32 2.76e-9 Type 2 diabetes; LUSC cis rs9341808 0.556 rs1474791 chr6:81033097 A/G cg08355045 chr6:80787529 NA 0.51 8.87 0.44 4.41e-17 Sitting height ratio; LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg23758822 chr17:41437982 NA 1.04 19.77 0.73 3.88e-58 Menopause (age at onset); LUSC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg05295671 chr13:79234353 RNF219 0.46 6.01 0.31 4.86e-9 Large artery stroke; LUSC cis rs7808935 0.768 rs739704 chr7:27989768 G/A cg22168087 chr7:27702803 HIBADH 0.53 6.4 0.33 5.39e-10 Prostate cancer; LUSC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg13206674 chr6:150067644 NUP43 0.55 8.59 0.43 3.41e-16 Lung cancer; LUSC cis rs12208915 0.848 rs9343834 chr6:79517671 G/A cg05283184 chr6:79620031 NA 0.42 5.68 0.3 2.92e-8 Left atrial antero-posterior diameter; LUSC cis rs4654899 1.000 rs10916921 chr1:21334542 C/T cg01072550 chr1:21505969 NA -0.55 -8.41 -0.42 1.23e-15 Superior frontal gyrus grey matter volume; LUSC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg01770232 chr7:22766155 IL6 0.39 5.66 0.3 3.29e-8 Lung cancer; LUSC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.83 -0.7 2.02e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs6754311 0.731 rs3754686 chr2:136603276 T/C cg07169764 chr2:136633963 MCM6 -0.63 -8.27 -0.41 3.24e-15 Mosquito bite size; LUSC cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg03146154 chr1:46216737 IPP 0.56 8.5 0.42 6.44e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg11845111 chr2:191398756 TMEM194B 0.54 9.31 0.45 1.71e-18 Pulse pressure; LUSC cis rs11676348 0.772 rs12694427 chr2:218945045 C/T cg18102446 chr2:218934044 RUFY4 0.37 5.94 0.31 7.21e-9 Ulcerative colitis; LUSC cis rs7202877 0.610 rs4888381 chr16:75356847 C/A cg03315344 chr16:75512273 CHST6 0.43 6.22 0.32 1.51e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs11758351 1.000 rs76722536 chr6:26192946 C/G cg06951627 chr6:26196580 NA 0.53 5.79 0.3 1.59e-8 Gout;Renal underexcretion gout; LUSC cis rs910316 0.836 rs6574212 chr14:75671659 G/A cg06637938 chr14:75390232 RPS6KL1 -0.47 -7.29 -0.37 2.29e-12 Height; LUSC cis rs9300255 0.698 rs4759416 chr12:123746357 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.18 -0.32 1.82e-9 Neutrophil percentage of white cells; LUSC cis rs12681288 0.862 rs2600487 chr8:1016903 C/T cg04851639 chr8:1020857 NA -0.39 -8.07 -0.4 1.24e-14 Schizophrenia; LUSC cis rs1018836 0.786 rs7016220 chr8:91606848 A/G cg16814680 chr8:91681699 NA -0.69 -11.22 -0.52 5.09e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg20283391 chr11:68216788 NA -0.54 -7.97 -0.4 2.57e-14 Total body bone mineral density; LUSC cis rs9815354 0.812 rs73073233 chr3:42010550 A/G cg03022575 chr3:42003672 ULK4 0.82 8.57 0.42 3.93e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.43e-32 Chronic sinus infection; LUSC cis rs9790314 0.905 rs4856739 chr3:160986710 A/C cg04691961 chr3:161091175 C3orf57 -0.35 -5.9 -0.31 8.87e-9 Morning vs. evening chronotype; LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg21782813 chr7:2030301 MAD1L1 0.52 8.7 0.43 1.53e-16 Bipolar disorder and schizophrenia; LUSC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -6.0 -0.31 5.25e-9 Intelligence (multi-trait analysis); LUSC cis rs2274273 0.905 rs28429419 chr14:55574793 T/C cg04306507 chr14:55594613 LGALS3 0.55 12.54 0.57 7.81e-30 Protein biomarker; LUSC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg10909506 chr17:38081995 ORMDL3 0.33 5.95 0.31 6.59e-9 Self-reported allergy; LUSC cis rs4629180 0.586 rs1848699 chr2:102137903 C/G cg01388757 chr2:102091195 RFX8 -0.36 -6.27 -0.32 1.12e-9 Chronic rhinosinusitis with nasal polyps; LUSC trans rs61931739 0.613 rs6488174 chr12:33756569 T/C cg26384229 chr12:38710491 ALG10B 0.43 6.24 0.32 1.31e-9 Morning vs. evening chronotype; LUSC cis rs459571 0.959 rs2073818 chr9:136918662 C/A cg13789015 chr9:136890014 NCRNA00094 0.71 13.07 0.58 7.86e-32 Platelet distribution width; LUSC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg26597838 chr10:835615 NA -0.81 -10.89 -0.51 7.72e-24 Eosinophil percentage of granulocytes; LUSC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg05717871 chr11:638507 DRD4 -0.36 -6.05 -0.31 3.95e-9 Systemic lupus erythematosus; LUSC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs829883 0.659 rs12366275 chr12:98920276 G/C cg25150519 chr12:98850993 NA -0.64 -8.7 -0.43 1.53e-16 Colorectal adenoma (advanced); LUSC cis rs7216064 1.000 rs12600941 chr17:65918807 A/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.19 -0.45 4.35e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg05340658 chr4:99064831 C4orf37 0.63 9.97 0.48 1.17e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2898290 0.694 rs2248909 chr8:11392093 A/C cg21775007 chr8:11205619 TDH -0.52 -7.74 -0.39 1.16e-13 Systolic blood pressure; LUSC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg03395651 chr16:88107091 BANP 0.37 5.65 0.3 3.49e-8 Menopause (age at onset); LUSC cis rs2295359 1.000 rs4655524 chr1:67629469 G/A cg12940439 chr1:67600707 NA 0.36 6.12 0.32 2.63e-9 Psoriasis; LUSC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg11764359 chr7:65958608 NA -0.41 -5.87 -0.31 1.04e-8 Calcium levels; LUSC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg18306943 chr3:40428807 ENTPD3 0.41 6.15 0.32 2.21e-9 Renal cell carcinoma; LUSC cis rs17255340 0.520 rs6935935 chr6:84130734 C/G cg08257003 chr6:84140564 ME1 0.37 9.11 0.45 7.7e-18 Platelet-derived growth factor BB levels; LUSC cis rs73206853 0.841 rs73191828 chr12:110946121 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 7.83e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg21724239 chr8:58056113 NA 0.57 6.58 0.34 1.84e-10 Developmental language disorder (linguistic errors); LUSC cis rs11690935 0.632 rs35854151 chr2:172657439 G/A cg13550731 chr2:172543902 DYNC1I2 0.57 8.75 0.43 1.04e-16 Schizophrenia; LUSC cis rs72772090 0.539 rs11748519 chr5:96119328 C/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.58 -0.34 1.83e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs72781680 0.898 rs112985192 chr2:24102797 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.8 0.3 1.56e-8 Lymphocyte counts; LUSC trans rs7746199 0.736 rs13193480 chr6:27702561 A/G cg01620082 chr3:125678407 NA -0.78 -7.29 -0.37 2.28e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs12406019 0.510 rs12126464 chr1:78608215 T/C cg20826526 chr3:156266748 SSR3 -0.5 -7.58 -0.38 3.51e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.56 -0.34 2.03e-10 Lung cancer; LUSC cis rs3847687 1.000 rs3847688 chr12:131525310 C/T cg13586425 chr12:131519906 GPR133 -0.26 -5.87 -0.31 1.02e-8 Longevity; LUSC cis rs3845702 0.736 rs1904850 chr2:180852767 A/G cg01881094 chr2:180872142 CWC22 -1.06 -12.49 -0.56 1.19e-29 Schizophrenia; LUSC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.05 -0.4 1.45e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9287719 0.674 rs11684157 chr2:10827157 C/A cg02196655 chr2:10830764 NOL10 0.34 5.79 0.3 1.64e-8 Prostate cancer; LUSC cis rs4792901 0.759 rs34409913 chr17:41564293 T/G cg22562494 chr17:41607896 ETV4 -0.32 -6.18 -0.32 1.85e-9 Dupuytren's disease; LUSC cis rs208515 0.525 rs4145045 chr6:66678949 T/C cg07460842 chr6:66804631 NA 1.01 13.91 0.61 4.95e-35 Exhaled nitric oxide levels; LUSC trans rs9755467 0.665 rs57706556 chr3:127181579 T/A cg12446303 chr6:168709593 DACT2 0.38 5.95 0.31 6.88e-9 Educational attainment (years of education); LUSC cis rs73198271 0.515 rs75990942 chr8:8639761 C/T cg01851573 chr8:8652454 MFHAS1 0.56 6.24 0.32 1.32e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16249894 chr13:21141322 IFT88 0.42 7.12 0.36 6.86e-12 Asthma; LUSC cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg06784218 chr1:46089804 CCDC17 -0.48 -9.34 -0.46 1.41e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs308403 0.600 rs309366 chr4:123661408 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.82 11.36 0.53 1.72e-25 Blood protein levels; LUSC cis rs503341 0.756 rs10897450 chr11:63593219 G/C cg04850017 chr11:63683019 RCOR2 0.3 5.82 0.3 1.4e-8 Pulse pressure; LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.24e-12 Platelet count; LUSC cis rs501916 0.634 rs8037600 chr15:48060331 A/G cg16110827 chr15:48056943 SEMA6D -0.4 -6.26 -0.32 1.16e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC trans rs61931739 0.853 rs11053002 chr12:34083499 T/C cg26384229 chr12:38710491 ALG10B -0.55 -8.79 -0.43 8.05e-17 Morning vs. evening chronotype; LUSC cis rs7584330 0.955 rs13432426 chr2:238388631 T/G cg16989719 chr2:238392110 NA -0.42 -7.16 -0.36 5.07e-12 Prostate cancer; LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg16647868 chr5:131706066 SLC22A5 0.4 6.18 0.32 1.86e-9 Breast cancer; LUSC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg10560079 chr2:191398806 TMEM194B 0.47 7.77 0.39 9.47e-14 Pulse pressure; LUSC cis rs10504229 0.516 rs4060631 chr8:57990757 G/A cg11062466 chr8:58055876 NA 0.39 5.79 0.3 1.58e-8 Developmental language disorder (linguistic errors); LUSC cis rs722599 0.683 rs10144860 chr14:75286426 T/C cg08847533 chr14:75593920 NEK9 0.45 6.36 0.33 6.47e-10 IgG glycosylation; LUSC cis rs17445774 1.000 rs17445774 chr2:200859249 A/G cg23649088 chr2:200775458 C2orf69 -0.64 -9.55 -0.46 2.97e-19 LDL cholesterol to HDL cholesterol ratio; LUSC cis rs6558174 0.965 rs1564595 chr8:22488939 A/G cg03733263 chr8:22462867 KIAA1967 0.48 6.46 0.33 3.61e-10 Breast cancer; LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.0 -0.58 1.54e-31 Platelet count; LUSC cis rs11098499 0.863 rs3822195 chr4:120471660 C/T cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.51 7.25 0.37 2.87e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6546537 0.824 rs3771543 chr2:69784255 C/T cg10773587 chr2:69614142 GFPT1 -0.59 -9.35 -0.46 1.35e-18 Serum thyroid-stimulating hormone levels; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.72 0.43 1.34e-16 Prudent dietary pattern; LUSC cis rs7131987 0.903 rs1991114 chr12:29392082 G/T cg09582351 chr12:29534625 ERGIC2 -0.32 -6.54 -0.34 2.36e-10 QT interval; LUSC cis rs7605827 0.930 rs6718736 chr2:15525875 C/T cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs11711311 1.000 rs2712348 chr3:113460614 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.53 7.31 0.37 1.99e-12 IgG glycosylation; LUSC cis rs8062405 1.000 rs8062405 chr16:28837906 C/T cg09754948 chr16:28834200 ATXN2L -0.41 -5.84 -0.3 1.25e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg12698349 chr2:225449008 CUL3 0.7 8.92 0.44 3.06e-17 IgE levels in asthmatics (D.p. specific); LUSC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg18230493 chr5:56204884 C5orf35 -0.78 -11.07 -0.52 1.73e-24 Initial pursuit acceleration; LUSC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg22166914 chr1:53195759 ZYG11B -0.73 -12.91 -0.58 3.18e-31 Monocyte count; LUSC cis rs68170813 0.523 rs12535093 chr7:107020182 C/T cg02696742 chr7:106810147 HBP1 -0.61 -9.06 -0.44 1.16e-17 Coronary artery disease; LUSC cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg11266682 chr4:10021025 SLC2A9 0.52 9.58 0.46 2.31e-19 Bone mineral density; LUSC cis rs28655083 1.000 rs8059347 chr16:77068259 C/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.41 -6.05 -0.31 3.88e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs3733585 0.699 rs4408959 chr4:9948868 C/T cg26043149 chr18:55253948 FECH -0.44 -6.81 -0.35 4.65e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg24733560 chr20:60626293 TAF4 0.41 6.7 0.34 8.69e-11 Body mass index; LUSC cis rs300703 0.542 rs300691 chr2:180171 C/A cg21211680 chr2:198530 NA -0.57 -6.91 -0.35 2.54e-11 Blood protein levels; LUSC trans rs10256972 0.616 rs4585652 chr7:1145396 A/G cg02673351 chr19:3532544 FZR1 -0.41 -5.96 -0.31 6.28e-9 Longevity;Endometriosis; LUSC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg00078996 chr12:132293329 NA -0.36 -5.65 -0.3 3.48e-8 Migraine; LUSC cis rs9322193 1.000 rs9377229 chr6:149928791 C/T cg13206674 chr6:150067644 NUP43 0.56 8.77 0.43 9.31e-17 Lung cancer; LUSC cis rs11690935 0.959 rs10204622 chr2:172588982 C/T cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.42 -0.62 5.29e-37 Schizophrenia; LUSC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.11e-11 Crohn's disease; LUSC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg24675056 chr1:15929824 NA 0.43 7.11 0.36 7.09e-12 Systolic blood pressure; LUSC cis rs1957429 0.614 rs17767870 chr14:65321737 G/A cg23373153 chr14:65346875 NA -0.84 -7.35 -0.37 1.55e-12 Pediatric areal bone mineral density (radius); LUSC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.91 -0.4 3.78e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg26384229 chr12:38710491 ALG10B 0.95 18.03 0.7 3.12e-51 Heart rate; LUSC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.76 0.35 6.23e-11 Cystic fibrosis severity; LUSC cis rs228769 0.673 rs228787 chr17:42099488 C/T cg19774624 chr17:42201019 HDAC5 0.63 8.28 0.41 2.98e-15 Bone mineral density (hip);Bone mineral density (spine); LUSC cis rs611744 0.647 rs633901 chr8:109242981 G/T cg21045802 chr8:109455806 TTC35 0.42 6.56 0.34 2.04e-10 Dupuytren's disease; LUSC cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg09876464 chr15:85330779 ZNF592 0.36 6.72 0.35 7.65e-11 P wave terminal force; LUSC cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg08999081 chr20:33150536 PIGU 0.37 6.84 0.35 3.89e-11 Height; LUSC cis rs12210905 0.688 rs72843177 chr6:27367414 A/G cg08851530 chr6:28072375 NA 0.97 6.41 0.33 4.91e-10 Hip circumference adjusted for BMI; LUSC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg01475377 chr6:109611718 NA -0.43 -7.79 -0.39 8.73e-14 Reticulocyte fraction of red cells; LUSC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg15147215 chr3:52552868 STAB1 -0.32 -6.33 -0.33 7.76e-10 Electroencephalogram traits; LUSC trans rs6582630 0.519 rs10880194 chr12:38302836 G/A cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs57244997 0.872 rs11759694 chr6:162405705 C/G cg17173639 chr6:162384350 PARK2 0.61 6.01 0.31 4.98e-9 Mosquito bite size; LUSC cis rs11122272 0.735 rs2250704 chr1:231486647 A/G cg06096015 chr1:231504339 EGLN1 0.56 9.8 0.47 4.44e-20 Hemoglobin concentration; LUSC cis rs11864453 0.647 rs9932062 chr16:72136055 T/C cg01557791 chr16:72042693 DHODH -0.43 -6.38 -0.33 6.06e-10 Fibrinogen levels; LUSC cis rs78572108 0.858 rs10173801 chr2:42262132 C/T cg00607755 chr2:42274082 PKDCC 0.35 6.24 0.32 1.34e-9 Total body bone mineral density; LUSC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg23283495 chr1:209979779 IRF6 0.66 8.49 0.42 6.64e-16 Cleft lip with or without cleft palate; LUSC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg22875332 chr1:76189707 ACADM 0.75 10.04 0.48 6.69e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg12463550 chr7:65579703 CRCP -0.43 -6.31 -0.33 8.67e-10 Aortic root size; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.41 0.42 1.2e-15 Prudent dietary pattern; LUSC cis rs17001868 0.568 rs9607701 chr22:40739116 A/G cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs7712401 0.525 rs2910150 chr5:122296745 G/T cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC trans rs9944715 0.954 rs6507691 chr18:43808648 T/C cg01718231 chr17:29326311 RNF135 -0.53 -7.36 -0.37 1.42e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg15839431 chr19:19639596 YJEFN3 -0.58 -6.27 -0.32 1.12e-9 Bipolar disorder; LUSC cis rs2731664 0.792 rs335434 chr5:176867276 A/G cg23176889 chr5:176863531 GRK6 -0.67 -12.7 -0.57 2.05e-30 Intelligence (multi-trait analysis); LUSC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg20573242 chr4:122745356 CCNA2 0.64 9.03 0.44 1.36e-17 Type 2 diabetes; LUSC cis rs7241530 0.662 rs12966267 chr18:75900507 T/C cg14642773 chr18:75888474 NA 0.37 5.74 0.3 2.08e-8 Educational attainment (years of education); LUSC trans rs6502050 0.835 rs67682841 chr17:80117745 T/C cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.98 -21.15 -0.76 1.34e-63 Prudent dietary pattern; LUSC cis rs765787 0.530 rs1706837 chr15:45519036 A/G cg25801113 chr15:45476975 SHF 0.35 7.35 0.37 1.58e-12 Uric acid levels; LUSC cis rs3916 1.000 rs2014355 chr12:121175524 A/G cg27246729 chr12:121163418 ACADS 0.44 6.53 0.34 2.49e-10 Urinary metabolites (H-NMR features); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21037378 chr4:142142045 ZNF330 -0.41 -6.06 -0.31 3.75e-9 Electrocardiographic conduction measures; LUSC cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg05294307 chr14:35346193 BAZ1A -0.56 -6.3 -0.33 9.49e-10 Psoriasis; LUSC cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg08270630 chr22:50330655 NA 0.4 5.93 0.31 7.51e-9 Schizophrenia; LUSC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg15556689 chr8:8085844 FLJ10661 -0.66 -10.57 -0.5 1.02e-22 Mood instability; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23418208 chr14:104182045 ZFYVE21;XRCC3 0.44 6.13 0.32 2.42e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7605827 0.930 rs10929374 chr2:15676884 T/A cg19274914 chr2:15703543 NA 0.44 8.34 0.41 2.04e-15 Educational attainment (years of education); LUSC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg16325326 chr1:53192061 ZYG11B -0.85 -14.4 -0.62 6.79e-37 Monocyte count; LUSC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs17030434 0.954 rs17030570 chr4:154755186 A/G cg14289246 chr4:154710475 SFRP2 0.52 6.4 0.33 5.29e-10 Electrocardiographic conduction measures; LUSC cis rs12704876 0.530 rs2177675 chr7:96342253 A/T cg03808172 chr7:96339361 SHFM1 0.54 8.17 0.41 6.37e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.41 -0.42 1.24e-15 Joint mobility (Beighton score); LUSC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg14552801 chr7:65878734 NA 0.46 6.58 0.34 1.79e-10 Aortic root size; LUSC cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg24812749 chr6:127587940 RNF146 0.91 13.51 0.59 1.7e-33 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08131848 chr9:88420837 LOC389765 -0.41 -5.98 -0.31 5.58e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg21699342 chr2:239360505 ASB1 0.54 10.38 0.49 4.51e-22 Multiple system atrophy; LUSC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg15744005 chr10:104629667 AS3MT -0.29 -6.28 -0.32 1.05e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11122272 0.735 rs2474633 chr1:231486989 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.73 -0.47 7.36e-20 Hemoglobin concentration; LUSC cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg06627628 chr2:24431161 ITSN2 -0.6 -7.32 -0.37 1.86e-12 Lymphocyte counts; LUSC trans rs2840044 0.963 rs225247 chr17:33944590 T/A cg19694781 chr19:47549865 TMEM160 -0.59 -9.41 -0.46 8.5e-19 Response to radiotherapy in cancer (late toxicity); LUSC trans rs12579753 0.830 rs12825476 chr12:82238350 G/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs7917772 0.582 rs12411442 chr10:104349531 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.26e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9322193 0.504 rs7771014 chr6:150205446 T/A cg07701084 chr6:150067640 NUP43 0.47 7.01 0.36 1.35e-11 Lung cancer; LUSC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs1107366 1.000 rs1107366 chr3:125904165 A/G cg08481491 chr3:125900108 ALDH1L1 -0.31 -6.44 -0.33 4.27e-10 Metabolite levels; LUSC cis rs4356932 1.000 rs6826163 chr4:76973445 A/G cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs9902453 0.740 rs2244247 chr17:28110174 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.67 -0.54 1.26e-26 Coffee consumption (cups per day); LUSC cis rs7937682 0.575 rs7930208 chr11:111741463 T/C cg09085632 chr11:111637200 PPP2R1B 0.96 13.28 0.59 1.29e-32 Primary sclerosing cholangitis; LUSC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg05855489 chr10:104503620 C10orf26 0.59 9.35 0.46 1.29e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs853679 1.000 rs853685 chr6:28288785 C/T cg06606381 chr12:133084897 FBRSL1 -0.58 -6.29 -0.33 9.79e-10 Depression; LUSC cis rs35000415 0.873 rs13246321 chr7:128701331 T/C cg19972273 chr7:128594194 NA 0.63 5.72 0.3 2.34e-8 Systemic lupus erythematosus; LUSC cis rs73001065 0.901 rs73004951 chr19:19695228 C/T cg03709012 chr19:19516395 GATAD2A 0.9 7.18 0.37 4.52e-12 LDL cholesterol; LUSC cis rs67366981 1.000 rs8006117 chr14:77713279 G/A cg22824376 chr14:77648248 TMEM63C 0.65 6.19 0.32 1.75e-9 Obsessive-compulsive symptoms; LUSC cis rs1065656 0.619 rs2492883 chr16:1902105 C/T cg00564555 chr16:1970112 NA -0.35 -5.87 -0.31 1.02e-8 Insulin-like growth factors; LUSC cis rs12681287 0.517 rs34596274 chr8:87517679 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.28 -0.37 2.44e-12 Caudate activity during reward; LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg19318889 chr4:1322082 MAEA -0.78 -13.96 -0.61 3.39e-35 Longevity; LUSC cis rs8044868 0.530 rs2287999 chr16:72059149 A/G cg16579770 chr16:72058938 DHODH 0.34 5.78 0.3 1.73e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg16060761 chr17:80687452 NA 0.41 6.32 0.33 8.3e-10 Breast cancer; LUSC cis rs6570726 1.000 rs1935617 chr6:145943326 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.99 0.31 5.53e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.68 0.63 5.62e-38 Platelet count; LUSC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg16624210 chr5:671434 TPPP 0.48 6.04 0.31 4.04e-9 Obesity-related traits; LUSC cis rs7726839 0.794 rs10053310 chr5:595661 C/G cg09021430 chr5:549028 NA -0.6 -9.39 -0.46 9.53e-19 Obesity-related traits; LUSC cis rs11105298 0.891 rs10858854 chr12:89835728 C/A cg00757033 chr12:89920650 WDR51B 0.58 9.71 0.47 8.6e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.57e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9916302 0.706 rs12937013 chr17:37665571 G/A cg07936489 chr17:37558343 FBXL20 -0.82 -9.8 -0.47 4.44e-20 Glomerular filtration rate (creatinine); LUSC cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.59 0.5 8.45e-23 Bone mineral density; LUSC cis rs3806843 0.518 rs2569188 chr5:140008419 G/A cg26395211 chr5:140044315 WDR55 0.41 6.4 0.33 5.34e-10 Depressive symptoms (multi-trait analysis); LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg03934478 chr11:495069 RNH1 0.84 9.68 0.47 1.11e-19 Body mass index; LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.51 0.65 3.1e-41 Platelet count; LUSC cis rs1215050 0.791 rs1215049 chr4:98848280 C/T cg05340658 chr4:99064831 C4orf37 0.44 7.19 0.37 4.24e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4343996 0.558 rs10281401 chr7:3416173 T/C cg21248987 chr7:3385318 SDK1 0.36 6.14 0.32 2.28e-9 Motion sickness; LUSC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg12560992 chr17:57184187 TRIM37 0.83 15.3 0.64 2e-40 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.697 rs28655325 chr4:120372999 A/G cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs61931739 0.513 rs1463634 chr12:33899621 A/G cg06521331 chr12:34319734 NA -0.35 -5.7 -0.3 2.61e-8 Morning vs. evening chronotype; LUSC cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg04117972 chr1:227635322 NA 0.61 7.06 0.36 9.55e-12 Major depressive disorder; LUSC cis rs4803468 1.000 rs3810175 chr19:41904396 C/T cg09537434 chr19:41945824 ATP5SL 0.89 16.19 0.66 6.46e-44 Height; LUSC cis rs7191700 0.511 rs12923756 chr16:11359675 C/T cg00044050 chr16:11439710 C16orf75 -0.7 -12.27 -0.56 7.97e-29 Multiple sclerosis; LUSC cis rs611744 0.647 rs13280487 chr8:109270263 G/C cg21045802 chr8:109455806 TTC35 0.44 6.89 0.35 2.85e-11 Dupuytren's disease; LUSC trans rs2727020 0.575 rs10769587 chr11:49549849 C/G cg15704280 chr7:45808275 SEPT13 -1.06 -20.17 -0.74 9.4e-60 Coronary artery disease; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg21132104 chr15:45694354 SPATA5L1 0.45 5.98 0.31 5.68e-9 Homoarginine levels; LUSC cis rs7119 0.689 rs12901765 chr15:77819103 C/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.63 -0.34 1.34e-10 Type 2 diabetes; LUSC cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg16482183 chr6:26056742 HIST1H1C 0.47 6.82 0.35 4.29e-11 Height; LUSC cis rs6754311 0.510 rs1374329 chr2:136421323 A/G cg07169764 chr2:136633963 MCM6 0.68 9.43 0.46 7.28e-19 Mosquito bite size; LUSC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg00334542 chr7:100209784 MOSPD3 -0.48 -5.68 -0.3 2.87e-8 Other erythrocyte phenotypes; LUSC trans rs6502050 0.814 rs62079997 chr17:80076888 C/T cg07393940 chr7:158741817 NA -0.37 -6.52 -0.34 2.55e-10 Life satisfaction; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg07677032 chr17:61819896 STRADA 0.53 8.77 0.43 9.43e-17 Prudent dietary pattern; LUSC cis rs6578985 1.000 rs6578986 chr11:2138152 A/G cg25742037 chr11:2171694 INS-IGF2;IGF2 0.33 6.18 0.32 1.89e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg10553204 chr2:20871195 GDF7 -0.34 -5.95 -0.31 6.86e-9 Abdominal aortic aneurysm; LUSC cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg08999081 chr20:33150536 PIGU 0.53 10.54 0.5 1.31e-22 Glomerular filtration rate (creatinine); LUSC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC cis rs4073582 0.595 rs2508657 chr11:66043898 G/A cg14036092 chr11:66035641 RAB1B 0.44 6.34 0.33 7.65e-10 Gout; LUSC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg22907277 chr7:1156413 C7orf50 0.62 7.4 0.38 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs8072100 1.000 rs8072100 chr17:45674687 A/T cg03886242 chr7:26192032 NFE2L3 0.36 6.03 0.31 4.39e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg23711669 chr6:146136114 FBXO30 0.88 16.26 0.66 3.3e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg07701084 chr6:150067640 NUP43 -0.56 -7.99 -0.4 2.24e-14 Lung cancer; LUSC cis rs2267681 0.603 rs194152 chr7:139539936 C/G cg14116596 chr7:139528673 TBXAS1 -0.37 -6.45 -0.33 3.96e-10 Cervical cancer; LUSC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg18351406 chr4:77819688 ANKRD56 -0.55 -8.18 -0.41 5.87e-15 Emphysema distribution in smoking; LUSC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg00750074 chr16:89608354 SPG7 -0.46 -6.92 -0.35 2.35e-11 Multiple myeloma (IgH translocation); LUSC cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg02423579 chr7:2872169 GNA12 -0.41 -6.52 -0.34 2.66e-10 Height; LUSC cis rs11098499 0.865 rs4001305 chr4:120359236 G/T cg09307838 chr4:120376055 NA 0.78 11.46 0.53 7.35e-26 Corneal astigmatism; LUSC cis rs10992471 0.603 rs11792019 chr9:95195229 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -7.95 -0.4 2.84e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs826838 0.933 rs980573 chr12:39127811 T/C cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg05347473 chr6:146136440 FBXO30 -0.55 -9.55 -0.46 2.84e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.562 rs8117491 chr20:33510120 T/C cg08999081 chr20:33150536 PIGU 0.32 5.65 0.3 3.51e-8 Height; LUSC cis rs9653442 0.932 rs893245 chr2:100814893 C/T cg22139774 chr2:100720529 AFF3 -0.45 -7.73 -0.39 1.24e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1997103 1.000 rs4947500 chr7:55407270 C/A cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2688608 0.905 rs2633300 chr10:75656647 A/C cg23231163 chr10:75533350 FUT11 -0.38 -6.23 -0.32 1.39e-9 Inflammatory bowel disease; LUSC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg13319975 chr6:146136371 FBXO30 -0.67 -10.06 -0.48 5.76e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs12421382 0.593 rs1808842 chr11:109389454 C/T cg27471124 chr11:109292789 C11orf87 0.38 6.94 0.35 2.08e-11 Schizophrenia; LUSC cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg16339924 chr4:17578868 LAP3 0.55 8.37 0.42 1.62e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4631830 0.869 rs11006207 chr10:51538176 T/C cg16070123 chr10:51489643 NA -0.51 -8.04 -0.4 1.59e-14 Prostate-specific antigen levels; LUSC cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg22455342 chr2:225449267 CUL3 0.77 10.43 0.5 3.11e-22 IgE levels in asthmatics (D.p. specific); LUSC cis rs9403521 1.000 rs6901659 chr6:143985106 T/C cg18240653 chr6:144019428 PHACTR2 -0.51 -6.21 -0.32 1.56e-9 Obesity-related traits; LUSC cis rs9868809 0.505 rs13434258 chr3:48738491 T/C cg00383909 chr3:49044727 WDR6 1.14 10.58 0.5 9.36e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2729354 0.768 rs2729384 chr11:57258617 T/C cg24343310 chr11:57249947 NA 0.46 8.65 0.43 2.19e-16 Blood protein levels; LUSC cis rs367943 0.712 rs1120091 chr5:112684229 C/A cg12552261 chr5:112820674 MCC 0.39 6.37 0.33 6.4e-10 Type 2 diabetes; LUSC cis rs13082711 0.863 rs13062327 chr3:27495573 G/A cg02860705 chr3:27208620 NA 0.47 7.8 0.39 8.1e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg09877947 chr5:131593287 PDLIM4 0.41 6.83 0.35 4.02e-11 Blood metabolite levels; LUSC cis rs4642101 0.534 rs13316229 chr3:12807371 C/T cg24848339 chr3:12840334 CAND2 0.33 6.44 0.33 4.24e-10 QRS complex (12-leadsum); LUSC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs870825 0.929 rs871253 chr4:185589234 G/A cg04058563 chr4:185651563 MLF1IP 0.83 10.8 0.51 1.6e-23 Blood protein levels; LUSC cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg08999081 chr20:33150536 PIGU 0.38 6.8 0.35 4.87e-11 Height; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18909525 chr9:132403873 ASB6 0.42 6.03 0.31 4.34e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6960043 0.738 rs10950549 chr7:15057829 G/A cg19272540 chr7:15055459 NA 0.34 8.21 0.41 4.77e-15 Type 2 diabetes; LUSC cis rs12701220 0.894 rs2141274 chr7:1034717 G/A cg20821713 chr7:1055600 C7orf50 -0.55 -7.24 -0.37 3.2e-12 Bronchopulmonary dysplasia; LUSC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs10489202 1.000 rs12408205 chr1:167982332 A/G cg24449463 chr1:168025552 DCAF6 -0.59 -7.39 -0.37 1.21e-12 Schizophrenia; LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6952808 0.792 rs11771973 chr7:1950440 C/G cg04565464 chr8:145669602 NFKBIL2 0.38 6.05 0.31 3.89e-9 Bipolar disorder and schizophrenia; LUSC cis rs7189233 0.531 rs7204758 chr16:53482365 G/A cg09728985 chr16:53543985 NA -0.3 -5.78 -0.3 1.73e-8 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs60869047 chr8:58053221 G/A cg11062466 chr8:58055876 NA 0.51 6.7 0.34 8.73e-11 Developmental language disorder (linguistic errors); LUSC cis rs7197653 0.748 rs58542611 chr16:68350219 C/T cg09835421 chr16:68378352 PRMT7 -0.8 -8.45 -0.42 9.21e-16 Magnesium levels; LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18099408 chr3:52552593 STAB1 -0.46 -8.2 -0.41 5.26e-15 Bipolar disorder; LUSC cis rs4588572 0.643 rs11744479 chr5:77729220 T/G cg11547950 chr5:77652471 NA -0.55 -7.98 -0.4 2.43e-14 Triglycerides; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G ch.3.343413R chr3:15058168 NR2C2 0.37 6.02 0.31 4.55e-9 Schizophrenia; LUSC cis rs921665 0.831 rs3792156 chr2:3196859 C/T cg02624386 chr2:3182749 NA -0.63 -6.19 -0.32 1.8e-9 World class endurance athleticism; LUSC cis rs9297145 0.916 rs6969140 chr7:98753900 G/A cg05967295 chr7:98741636 SMURF1 -0.96 -16.39 -0.67 1.01e-44 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03934478 chr11:495069 RNH1 0.84 9.73 0.47 7.23e-20 Body mass index; LUSC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg22105103 chr4:187893119 NA 0.71 13.9 0.61 5.76e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs11645898 0.745 rs55824906 chr16:72064905 A/G cg14768367 chr16:72042858 DHODH -0.73 -7.83 -0.39 6.44e-14 Blood protein levels; LUSC cis rs9788682 0.948 rs59133824 chr15:78833450 C/A cg18825076 chr15:78729989 IREB2 0.47 6.31 0.33 9.03e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7903847 0.701 rs11189173 chr10:99138792 T/C cg20016023 chr10:99160130 RRP12 -0.3 -6.49 -0.33 3.06e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs2795502 0.882 rs2744093 chr10:43339243 A/G cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs12760731 0.720 rs35905053 chr1:178441618 A/T cg00404053 chr1:178313656 RASAL2 0.59 6.32 0.33 8.28e-10 Obesity-related traits; LUSC cis rs4319547 0.956 rs7397990 chr12:123119472 T/C cg05707623 chr12:122985044 ZCCHC8 -0.57 -7.53 -0.38 4.87e-13 Body mass index; LUSC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg02782426 chr3:40428986 ENTPD3 0.42 7.79 0.39 8.29e-14 Renal cell carcinoma; LUSC cis rs500891 1.000 rs34681854 chr6:84162641 C/T cg08257003 chr6:84140564 ME1 0.35 7.14 0.36 5.99e-12 Platelet-derived growth factor BB levels; LUSC cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs6503525 0.628 rs4065985 chr17:38101932 G/C cg24910161 chr17:38119198 GSDMA -0.28 -5.95 -0.31 6.67e-9 Asthma; LUSC cis rs826838 1.000 rs826892 chr12:39100790 T/C cg26384229 chr12:38710491 ALG10B -0.84 -15.9 -0.66 8.8e-43 Heart rate; LUSC cis rs897984 0.609 rs1108431 chr16:31054607 C/T cg02466173 chr16:30829666 NA -0.54 -10.37 -0.49 5.05e-22 Dementia with Lewy bodies; LUSC cis rs11711311 0.955 rs10934241 chr3:113394705 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.0 0.31 5.2e-9 IgG glycosylation; LUSC cis rs9303401 0.659 rs12948133 chr17:56673602 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.7 0.6 3.15e-34 Cognitive test performance; LUSC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg14019146 chr3:50243930 SLC38A3 0.32 7.1 0.36 7.5e-12 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg16405210 chr4:1374714 KIAA1530 -0.52 -8.17 -0.41 6.39e-15 Obesity-related traits; LUSC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg00310523 chr12:86230176 RASSF9 0.54 10.05 0.48 5.93e-21 Major depressive disorder; LUSC trans rs72674100 1.000 rs2865757 chr4:97992597 C/T cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01035528 chr12:123460159 OGFOD2;ABCB9 -0.47 -6.32 -0.33 8.53e-10 Hepatitis; LUSC cis rs981844 1.000 rs2251994 chr4:154654097 C/T cg14289246 chr4:154710475 SFRP2 0.51 6.5 0.34 2.93e-10 Response to statins (LDL cholesterol change); LUSC cis rs6009527 0.752 rs7288176 chr22:49568462 A/G cg12746016 chr22:49560550 NA -0.48 -9.03 -0.44 1.38e-17 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs3008870 0.629 rs12742428 chr1:67426487 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.33 0.56 4.72e-29 Lymphocyte percentage of white cells; LUSC trans rs2228479 0.681 rs7196840 chr16:89959647 A/G cg24644049 chr4:85504048 CDS1 0.69 7.03 0.36 1.15e-11 Skin colour saturation; LUSC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4680 1.000 rs165656 chr22:19948863 C/G cg23601416 chr22:19950040 COMT -0.3 -6.23 -0.32 1.43e-9 Blood metabolite levels; LUSC cis rs10782582 0.593 rs6673786 chr1:76149637 C/T cg22875332 chr1:76189707 ACADM -0.41 -6.04 -0.31 4.06e-9 Daytime sleep phenotypes; LUSC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg26587870 chr6:27730563 NA -0.66 -5.94 -0.31 7.24e-9 Depression; LUSC cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.67 0.34 1.09e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg04727924 chr7:799746 HEATR2 -0.54 -6.77 -0.35 5.72e-11 Cerebrospinal P-tau181p levels; LUSC cis rs2652834 0.851 rs1126312 chr15:63427638 C/T cg05507819 chr15:63340323 TPM1 -0.45 -5.84 -0.3 1.23e-8 HDL cholesterol; LUSC cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg11102782 chr19:18549136 ISYNA1 -0.34 -6.56 -0.34 2.09e-10 Breast cancer; LUSC cis rs4919694 1.000 rs12261040 chr10:104665397 T/C cg04362960 chr10:104952993 NT5C2 1.1 12.9 0.58 3.57e-31 Arsenic metabolism; LUSC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.54 0.34 2.24e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs11105298 0.891 rs10858852 chr12:89833338 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -7.36 -0.37 1.4e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg09267113 chr7:98030324 BAIAP2L1 0.39 5.87 0.31 1.07e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg18876405 chr7:65276391 NA -0.53 -8.4 -0.42 1.28e-15 Aortic root size; LUSC cis rs11997175 0.520 rs6994803 chr8:33817796 A/G ch.8.33884649F chr8:33765107 NA 0.43 6.64 0.34 1.3e-10 Body mass index; LUSC cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg24812749 chr6:127587940 RNF146 0.91 13.39 0.59 5.07e-33 Breast cancer; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg14159672 chr1:205819179 PM20D1 0.98 21.23 0.76 6.43e-64 Menarche (age at onset); LUSC cis rs6598955 0.543 rs112752634 chr1:26534217 G/A cg12744634 chr1:26560303 CCDC21 0.39 5.84 0.3 1.25e-8 Obesity-related traits; LUSC cis rs1044826 0.692 rs295484 chr3:139231782 A/G cg00490450 chr3:139108681 COPB2 -0.45 -7.01 -0.36 1.3e-11 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02796621 chr17:19248565 MIR1180;B9D1 -0.37 -6.28 -0.32 1.07e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs782590 1.000 rs782594 chr2:55844445 T/C cg03859395 chr2:55845619 SMEK2 0.86 16.21 0.66 5.09e-44 Metabolic syndrome; LUSC cis rs710216 0.797 rs841856 chr1:43400113 G/T cg22176566 chr1:43424700 SLC2A1 0.49 6.02 0.31 4.67e-9 Red cell distribution width; LUSC cis rs2219968 1.000 rs4541901 chr8:78971715 G/A cg00738934 chr8:78996279 NA 0.37 6.78 0.35 5.62e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7568458 0.846 rs1078004 chr2:85769711 C/G cg23752985 chr2:85803571 VAMP8 0.34 7.13 0.36 6.21e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2179367 0.600 rs9498355 chr6:149763410 C/T cg07828024 chr6:149772892 ZC3H12D 0.36 6.25 0.32 1.28e-9 Dupuytren's disease; LUSC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg18350739 chr11:68623251 NA -0.36 -6.2 -0.32 1.67e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg24110177 chr3:50126178 RBM5 -0.55 -8.97 -0.44 2.12e-17 Intelligence (multi-trait analysis); LUSC trans rs7618501 0.633 rs6771546 chr3:49968572 T/C cg21659725 chr3:3221576 CRBN 0.63 10.53 0.5 1.38e-22 Intelligence (multi-trait analysis); LUSC cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg26384229 chr12:38710491 ALG10B 0.68 10.72 0.51 3.03e-23 Morning vs. evening chronotype; LUSC cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7481584 0.646 rs434114 chr11:3050210 A/G cg25174290 chr11:3078921 CARS -0.42 -6.16 -0.32 2.11e-9 Calcium levels; LUSC cis rs7605827 0.866 rs4668901 chr2:15521677 A/G cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.82e-17 Educational attainment (years of education); LUSC cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg01884057 chr2:25150051 NA 0.47 11.03 0.52 2.54e-24 Body mass index; LUSC cis rs4654899 0.895 rs7515590 chr1:21216664 T/C cg01072550 chr1:21505969 NA 0.52 7.72 0.39 1.32e-13 Superior frontal gyrus grey matter volume; LUSC cis rs4843185 0.769 rs12149168 chr16:85705611 A/C cg05245094 chr16:85669572 KIAA0182 -0.43 -6.19 -0.32 1.76e-9 Platelet distribution width; LUSC trans rs1422110 0.519 rs12055343 chr5:85437684 T/C cg01787110 chr1:109008453 NBPF6 0.57 9.46 0.46 5.68e-19 Attention function in attention deficit hyperactive disorder; LUSC cis rs10504073 0.647 rs4873096 chr8:49995201 A/G cg00325661 chr8:49890786 NA 0.62 9.91 0.48 1.8899999999999998e-20 Blood metabolite ratios; LUSC cis rs77956314 0.515 rs4767473 chr12:117365506 C/T cg02017074 chr12:117425053 FBXW8 0.63 7.41 0.38 1.06e-12 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs4363385 0.510 rs11577384 chr1:152899728 C/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.16 -0.32 2.04e-9 Inflammatory skin disease; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg11494091 chr17:61959527 GH2 0.64 13.79 0.6 1.46e-34 Prudent dietary pattern; LUSC cis rs11718455 0.585 rs17076170 chr3:43917946 C/T cg08738300 chr3:44038990 NA 0.51 6.98 0.36 1.57e-11 Coronary artery disease; LUSC trans rs10435719 0.899 rs11250177 chr8:11799099 G/A cg15556689 chr8:8085844 FLJ10661 0.58 8.82 0.43 6.58e-17 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg16339924 chr4:17578868 LAP3 0.64 10.13 0.48 3.35e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg07424592 chr7:64974309 NA 0.67 5.89 0.31 9.46e-9 Diabetic kidney disease; LUSC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg21854759 chr1:92012499 NA 0.52 8.61 0.43 2.92e-16 Breast cancer; LUSC cis rs1577917 1.000 rs1018184 chr6:86648475 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.56 8.04 0.4 1.55e-14 Response to antipsychotic treatment; LUSC cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg12826209 chr6:26865740 GUSBL1 0.76 6.5 0.33 2.98e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs17270561 0.666 rs3923725 chr6:25734920 C/A cg16482183 chr6:26056742 HIST1H1C 0.66 9.22 0.45 3.37e-18 Iron status biomarkers; LUSC cis rs11190604 1.000 rs7100386 chr10:102301417 C/T cg23241863 chr10:102295624 HIF1AN 0.47 5.65 0.3 3.41e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9309473 0.898 rs28879089 chr2:73812886 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.56 -0.34 2.1e-10 Metabolite levels; LUSC trans rs11039798 0.588 rs584899 chr11:48431408 T/C cg03929089 chr4:120376271 NA -0.56 -6.1 -0.32 2.87e-9 Axial length; LUSC cis rs11105298 0.891 rs10858881 chr12:89891474 T/G cg00757033 chr12:89920650 WDR51B 0.58 10.23 0.49 1.51e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25450837 chr19:49631297 PPFIA3 -0.45 -6.67 -0.34 1.05e-10 Electrocardiographic conduction measures; LUSC cis rs17767294 0.572 rs11965137 chr6:27624749 G/A cg08851530 chr6:28072375 NA 0.78 5.75 0.3 2.04e-8 Parkinson's disease; LUSC cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs12760731 0.565 rs10913520 chr1:178200760 A/T cg00404053 chr1:178313656 RASAL2 0.66 6.86 0.35 3.32e-11 Obesity-related traits; LUSC cis rs8141529 0.664 rs5762861 chr22:29250505 T/G cg02153584 chr22:29168773 CCDC117 0.51 6.82 0.35 4.23e-11 Lymphocyte counts; LUSC cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg15225532 chr3:44803084 KIF15;KIAA1143 0.51 7.91 0.4 3.93e-14 Depressive symptoms; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg06145435 chr7:1022769 CYP2W1 0.28 5.67 0.3 3.17e-8 Longevity;Endometriosis; LUSC cis rs12210905 0.688 rs12205044 chr6:27478990 A/G cg08851530 chr6:28072375 NA 0.93 5.93 0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg21963583 chr11:68658836 MRPL21 -0.56 -8.53 -0.42 5.15e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2652822 0.967 rs1472631 chr15:63423739 A/G cg02713581 chr15:63449717 RPS27L 0.42 6.62 0.34 1.4e-10 Metabolic traits; LUSC cis rs7589342 0.894 rs6736932 chr2:106444854 A/G cg14210321 chr2:106509881 NCK2 -0.55 -8.36 -0.42 1.66e-15 Addiction; LUSC cis rs4555082 0.874 rs11625098 chr14:105756891 A/G cg27165867 chr14:105738592 BRF1 -0.54 -7.42 -0.38 9.61e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs13064411 0.696 rs6773497 chr3:113186514 T/C cg18753928 chr3:113234510 CCDC52 -0.53 -8.05 -0.4 1.51e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs4319547 1.000 rs6489157 chr12:123101673 C/G cg23029597 chr12:123009494 RSRC2 0.69 9.61 0.47 1.85e-19 Body mass index; LUSC cis rs6740322 0.895 rs10172375 chr2:43572047 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -6.82 -0.35 4.4e-11 Coronary artery disease; LUSC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs7106204 0.609 rs72874176 chr11:24330205 C/T ch.11.24196551F chr11:24239977 NA 0.69 5.71 0.3 2.48e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg00522288 chr12:125625016 AACS -0.31 -5.95 -0.31 6.86e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg26102564 chr10:131424627 MGMT 0.4 6.18 0.32 1.89e-9 Response to temozolomide; LUSC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs4076764 0.846 rs12035840 chr1:163419177 G/C cg24596788 chr1:163392923 NA -0.38 -6.54 -0.34 2.3e-10 Motion sickness; LUSC cis rs4308124 0.708 rs6749633 chr2:111988016 A/G cg04571233 chr2:111982156 NA 0.51 6.71 0.34 8.39e-11 Vitiligo; LUSC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg05347473 chr6:146136440 FBXO30 0.48 7.9 0.4 4.04e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs977987 0.843 rs4888415 chr16:75448921 C/T cg03315344 chr16:75512273 CHST6 0.52 9.95 0.48 1.32e-20 Dupuytren's disease; LUSC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg13607699 chr17:42295918 UBTF -0.76 -14.48 -0.62 3.3e-37 Total body bone mineral density; LUSC cis rs10876993 0.821 rs1678522 chr12:58049923 G/A cg15848620 chr12:58087721 OS9 -0.53 -7.55 -0.38 4.25e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs748404 0.723 rs573169 chr15:43550581 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.99 0.31 5.3e-9 Lung cancer; LUSC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg06634786 chr22:41940651 POLR3H -0.55 -6.45 -0.33 4.04e-10 Vitiligo; LUSC cis rs12600856 1 rs12600856 chr17:38163295 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.94 -0.36 1.99e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg15704280 chr7:45808275 SEPT13 -1.08 -21.89 -0.77 1.67e-66 Height; LUSC cis rs6906287 0.625 rs11968351 chr6:118901509 G/A cg21191810 chr6:118973309 C6orf204 0.33 6.11 0.32 2.77e-9 Electrocardiographic conduction measures; LUSC cis rs4595586 0.545 rs1156705 chr12:39372672 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.75e-9 Morning vs. evening chronotype; LUSC cis rs9300255 0.739 rs1402275 chr12:123750895 A/G cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.57 -0.34 1.95e-10 Neutrophil percentage of white cells; LUSC cis rs17030434 1.000 rs78249279 chr4:154718783 C/T cg14289246 chr4:154710475 SFRP2 -0.52 -6.7 -0.34 8.97e-11 Electrocardiographic conduction measures; LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17216600 chr6:52442344 TRAM2 -0.51 -6.27 -0.32 1.12e-9 Bipolar disorder and schizophrenia; LUSC trans rs62458065 0.513 rs7805536 chr7:32573570 T/C cg00845942 chr12:64062724 DPY19L2 -0.62 -7.87 -0.4 5.15e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.74 0.39 1.22e-13 Hemoglobin concentration; LUSC cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg06784218 chr1:46089804 CCDC17 -0.58 -11.51 -0.53 4.82e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13256369 0.755 rs11776987 chr8:8559401 C/G cg17143192 chr8:8559678 CLDN23 0.64 8.81 0.43 6.71e-17 Obesity-related traits; LUSC cis rs7833790 0.777 rs7815272 chr8:82691809 T/G cg02079420 chr8:82753780 SNX16 0.4 5.99 0.31 5.57e-9 Diastolic blood pressure; LUSC trans rs7824557 0.602 rs11784458 chr8:11204184 G/A cg15556689 chr8:8085844 FLJ10661 0.49 7.25 0.37 2.87e-12 Retinal vascular caliber; LUSC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg19592336 chr6:28129416 ZNF389 0.45 5.85 0.3 1.16e-8 Depression; LUSC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg18512352 chr11:47633146 NA -0.48 -9.65 -0.47 1.38e-19 Subjective well-being; LUSC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg00343986 chr7:65444356 GUSB 0.44 6.72 0.35 7.92e-11 Aortic root size; LUSC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs77741769 0.700 rs7980311 chr12:121355860 C/T cg02403541 chr12:121454288 C12orf43 0.48 7.24 0.37 3.15e-12 Mean corpuscular volume; LUSC cis rs7605827 0.930 rs1473178 chr2:15576750 T/C cg19274914 chr2:15703543 NA 0.47 8.88 0.44 4.19e-17 Educational attainment (years of education); LUSC cis rs732765 0.602 rs2359192 chr14:75410523 A/C cg06637938 chr14:75390232 RPS6KL1 -0.51 -6.31 -0.33 9.11e-10 Non-small cell lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03698729 chr19:2328812 SPPL2B;LSM7 -0.38 -6.08 -0.32 3.27e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7568458 0.837 rs12714145 chr2:85787341 C/T cg17127132 chr2:85788382 GGCX 0.46 7.55 0.38 4.3e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg06640241 chr16:89574553 SPG7 0.69 11.04 0.52 2.35e-24 Multiple myeloma (IgH translocation); LUSC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg19774624 chr17:42201019 HDAC5 -0.79 -12.73 -0.57 1.57e-30 Total body bone mineral density; LUSC cis rs9326248 0.559 rs10892052 chr11:116834313 G/A cg11861562 chr11:117069780 TAGLN 0.33 6.36 0.33 6.48e-10 Blood protein levels; LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs6066835 1.000 rs6066820 chr20:47318444 T/C cg18078177 chr20:47281410 PREX1 0.72 6.13 0.32 2.51e-9 Multiple myeloma; LUSC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg08219700 chr8:58056026 NA 0.73 12.16 0.55 1.97e-28 Developmental language disorder (linguistic errors); LUSC cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 7.02 0.36 1.22e-11 Rheumatoid arthritis; LUSC cis rs11098499 0.954 rs6849561 chr4:120409694 C/G cg24375607 chr4:120327624 NA -0.75 -10.82 -0.51 1.32e-23 Corneal astigmatism; LUSC cis rs4566357 0.615 rs1800517 chr2:227915832 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -8.11 -0.41 9.41e-15 Coronary artery disease; LUSC cis rs12701220 0.817 rs1058729 chr7:1087283 C/T cg20821713 chr7:1055600 C7orf50 -0.47 -6.38 -0.33 5.81e-10 Bronchopulmonary dysplasia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T ch.7.118285014F chr7:118497780 NA -0.54 -7.16 -0.36 5.01e-12 Hepatitis; LUSC cis rs295140 0.507 rs4673814 chr2:201108133 G/A cg23649088 chr2:200775458 C2orf69 -0.43 -6.47 -0.33 3.41e-10 QT interval; LUSC trans rs7100689 0.784 rs10749562 chr10:82108253 G/T cg07663200 chr17:42030104 NA -0.38 -6.04 -0.31 4.14e-9 Post bronchodilator FEV1; LUSC cis rs7940866 0.838 rs7949071 chr11:130877478 T/C cg12179176 chr11:130786555 SNX19 0.59 9.25 0.45 2.78e-18 Schizophrenia; LUSC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.51 0.67 3.54e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg19622623 chr12:86230825 RASSF9 -0.41 -5.66 -0.3 3.31e-8 Major depressive disorder; LUSC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg07211511 chr3:129823064 LOC729375 -0.62 -8.21 -0.41 4.72e-15 Blood pressure (smoking interaction); LUSC cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg11266682 chr4:10021025 SLC2A9 0.58 10.66 0.5 5.01e-23 Bone mineral density; LUSC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs514406 0.536 rs878957 chr1:53197559 C/T cg22166914 chr1:53195759 ZYG11B -0.63 -10.77 -0.51 1.99e-23 Monocyte count; LUSC trans rs7937682 0.632 rs11214037 chr11:111773296 C/T cg18187862 chr3:45730750 SACM1L -0.54 -6.6 -0.34 1.62e-10 Primary sclerosing cholangitis; LUSC cis rs926938 0.563 rs360576 chr1:115459174 A/C cg12756093 chr1:115239321 AMPD1 -0.43 -5.92 -0.31 7.78e-9 Autism; LUSC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg14159672 chr1:205819179 PM20D1 0.45 6.11 0.32 2.7e-9 Parkinson's disease; LUSC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC trans rs1493916 0.837 rs11876492 chr18:31413804 T/C cg13755796 chr4:20253514 NA -0.39 -6.08 -0.32 3.21e-9 Life satisfaction; LUSC cis rs859767 0.741 rs1467194 chr2:135430621 A/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.27 -0.32 1.09e-9 Neuroticism; LUSC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg01765077 chr12:122356316 WDR66 0.56 7.88 0.4 4.67e-14 Mean corpuscular volume; LUSC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg20283391 chr11:68216788 NA 0.55 8.43 0.42 1.03e-15 Total body bone mineral density; LUSC cis rs1595825 0.891 rs76450397 chr2:198786112 T/C cg10547527 chr2:198650123 BOLL -0.49 -5.79 -0.3 1.65e-8 Ulcerative colitis; LUSC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg26513180 chr16:89883248 FANCA 0.9 17.69 0.7 6.93e-50 Vitiligo; LUSC cis rs7809950 1.000 rs17154077 chr7:107077941 C/T cg23024343 chr7:107201750 COG5 0.55 8.78 0.43 8.71e-17 Coronary artery disease; LUSC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.63 9.79 0.47 4.77e-20 Cognitive test performance; LUSC cis rs1577917 1.000 rs1911552 chr6:86638024 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg13395646 chr4:1353034 KIAA1530 0.61 9.62 0.47 1.7e-19 Obesity-related traits; LUSC cis rs1371867 0.810 rs2919470 chr8:101233301 C/A cg00191853 chr8:101177733 SPAG1 0.41 6.64 0.34 1.3100000000000001e-10 Atrioventricular conduction; LUSC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg23583168 chr7:148888333 NA -0.81 -13.99 -0.61 2.55e-35 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs73129298 0.551 rs60541386 chr20:48602508 T/C cg25655593 chr20:48599521 SNAI1 0.58 6.28 0.33 1.03e-9 Inflammatory skin disease; LUSC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg23283495 chr1:209979779 IRF6 0.73 9.47 0.46 5.2e-19 Cleft lip with or without cleft palate; LUSC cis rs9925964 0.900 rs56813533 chr16:31070481 A/T cg02466173 chr16:30829666 NA 0.36 6.59 0.34 1.7e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3812831 0.695 rs7995986 chr13:114938802 A/G cg08824895 chr13:115047677 UPF3A 0.54 8.25 0.41 3.6e-15 Schizophrenia; LUSC cis rs7107174 0.892 rs2512534 chr11:77970039 T/A cg02023728 chr11:77925099 USP35 0.52 7.2 0.37 4.11e-12 Testicular germ cell tumor; LUSC cis rs861020 0.630 rs685248 chr1:210008367 C/G cg05527609 chr1:210001259 C1orf107 0.68 9.79 0.47 4.7e-20 Orofacial clefts; LUSC cis rs2172802 0.693 rs7660566 chr4:62481231 G/T cg04118610 chr4:62707027 LPHN3 0.46 6.31 0.33 8.99e-10 Partial epilepsies; LUSC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg06636001 chr8:8085503 FLJ10661 0.85 14.7 0.63 4.66e-38 Neuroticism; LUSC cis rs524023 1.000 rs10792441 chr11:64360629 C/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.33 -0.49 6.6e-22 Urate levels in obese individuals; LUSC cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg19875535 chr5:140030758 IK 0.47 7.57 0.38 3.58e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs72781680 0.898 rs72780123 chr2:23996009 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs12101261 0.580 rs3783949 chr14:81448382 A/C cg06600135 chr14:81408086 NA 0.44 6.84 0.35 3.82e-11 Graves' disease; LUSC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg06675483 chr6:26987649 LOC100270746;C6orf41 0.31 6.36 0.33 6.53e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7715806 0.500 rs17563974 chr5:75004175 G/A cg19683494 chr5:74908142 NA 0.57 7.68 0.39 1.83e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg20553930 chr7:120590671 ING3 0.4 6.2 0.32 1.71e-9 Asthma; LUSC cis rs7241530 0.610 rs7226819 chr18:75892508 C/T cg14642773 chr18:75888474 NA 0.39 5.9 0.31 8.96e-9 Educational attainment (years of education); LUSC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg09359103 chr1:154839909 KCNN3 -0.71 -16.53 -0.67 2.9e-45 Prostate cancer; LUSC cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.1e-40 Bladder cancer; LUSC cis rs9611519 0.894 rs4821990 chr22:41438710 A/C cg03806693 chr22:41940476 POLR3H -0.51 -6.98 -0.36 1.55e-11 Neuroticism; LUSC cis rs6121246 0.697 rs6088864 chr20:30228157 G/A cg21427119 chr20:30132790 HM13 -0.42 -6.12 -0.32 2.63e-9 Mean corpuscular hemoglobin; LUSC cis rs9902453 0.868 rs9896012 chr17:28470091 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.13 0.45 6.89e-18 Coffee consumption (cups per day); LUSC cis rs977987 0.527 rs62059844 chr16:75429737 T/C cg03315344 chr16:75512273 CHST6 0.49 9.22 0.45 3.5e-18 Dupuytren's disease; LUSC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg26695010 chr11:65641043 EFEMP2 0.41 5.74 0.3 2.13e-8 Breast cancer; LUSC cis rs2019216 0.542 rs7217513 chr17:21933536 C/A cg22648282 chr17:21454238 C17orf51 -0.53 -7.9 -0.4 4.08e-14 Pelvic organ prolapse; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03208850 chr16:3333472 ZNF263 0.72 6.11 0.32 2.73e-9 Cognitive performance; LUSC cis rs2486288 0.656 rs11637838 chr15:45550657 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.98 -0.4 2.38e-14 Glomerular filtration rate; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg20295408 chr7:1910781 MAD1L1 -0.45 -6.47 -0.33 3.41e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26615712 chr19:34856250 GPI -0.45 -6.7 -0.34 8.98e-11 Electrocardiographic conduction measures; LUSC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs11122272 0.735 rs2790885 chr1:231529925 C/T cg06096015 chr1:231504339 EGLN1 0.58 10.45 0.5 2.68e-22 Hemoglobin concentration; LUSC cis rs9467773 1.000 rs1884949 chr6:26568067 G/A cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg07677032 chr17:61819896 STRADA 0.55 9.1 0.45 8.12e-18 Prudent dietary pattern; LUSC trans rs208520 0.874 rs208514 chr6:66945520 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -13.76 -0.6 1.92e-34 Exhaled nitric oxide output; LUSC cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg05043794 chr9:111880884 C9orf5 -0.34 -7.3 -0.37 2.15e-12 Menarche (age at onset); LUSC cis rs2295359 0.892 rs17375018 chr1:67655147 A/G cg17031739 chr1:67600172 NA -0.43 -6.8 -0.35 4.96e-11 Psoriasis; LUSC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg18225595 chr11:63971243 STIP1 0.5 6.13 0.32 2.48e-9 Mean platelet volume; LUSC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.38 0.46 1.07e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10193935 0.901 rs59984817 chr2:42566909 C/G cg27598129 chr2:42591480 NA -0.61 -8.26 -0.41 3.47e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -7.66 -0.39 2.08e-13 Bone mineral density; LUSC cis rs7020830 0.898 rs7846747 chr9:37167539 A/C cg14294708 chr9:37120828 ZCCHC7 1.09 24.26 0.8 1.12e-75 Schizophrenia; LUSC cis rs765787 0.530 rs1648286 chr15:45517386 G/C cg25801113 chr15:45476975 SHF 0.36 7.35 0.37 1.52e-12 Uric acid levels; LUSC cis rs76878669 0.515 rs12576299 chr11:66132286 T/C cg24851651 chr11:66362959 CCS -0.36 -5.73 -0.3 2.25e-8 Educational attainment (years of education); LUSC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg02951883 chr7:2050386 MAD1L1 -0.53 -9.4 -0.46 8.68e-19 Schizophrenia; LUSC cis rs7818345 0.967 rs12679712 chr8:19271032 C/G cg11303988 chr8:19266685 CSGALNACT1 0.35 6.84 0.35 3.82e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7804356 1.000 rs3801826 chr7:26856720 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg24692254 chr21:30365293 RNF160 0.92 18.96 0.72 6.03e-55 Dental caries; LUSC cis rs1568889 1.000 rs7102106 chr11:28343953 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 8.77 0.43 9.11e-17 Bipolar disorder; LUSC cis rs7208859 0.573 rs56031503 chr17:29075665 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.02 0.36 1.22e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2625529 0.526 rs11634622 chr15:72562327 G/A cg16672083 chr15:72433130 SENP8 0.47 7.8 0.39 7.96e-14 Red blood cell count; LUSC cis rs7582180 0.629 rs11685250 chr2:100955137 C/T cg12002119 chr2:101014098 CHST10 0.35 5.65 0.3 3.35e-8 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00929050 chr14:50359216 ARF6 -0.44 -6.73 -0.35 7.45e-11 Electrocardiographic conduction measures; LUSC cis rs6121246 0.529 rs58757492 chr20:30181425 G/A cg21427119 chr20:30132790 HM13 -0.43 -6.15 -0.32 2.26e-9 Mean corpuscular hemoglobin; LUSC trans rs7937682 0.889 rs487985 chr11:111517908 G/A cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg00814883 chr7:100076585 TSC22D4 -0.75 -10.26 -0.49 1.18e-21 Platelet count; LUSC cis rs1908814 0.516 rs10113062 chr8:11793249 A/G cg21775007 chr8:11205619 TDH 0.47 6.67 0.34 1.09e-10 Neuroticism; LUSC cis rs6469656 0.881 rs10505287 chr8:117727850 C/T cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg09323728 chr8:95962352 TP53INP1 -0.29 -5.71 -0.3 2.54e-8 Type 2 diabetes; LUSC cis rs3764563 1.000 rs8107240 chr19:15737392 A/G cg20725493 chr19:15740067 CYP4F8 -0.64 -6.62 -0.34 1.44e-10 Inflammatory biomarkers; LUSC cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg04850211 chr1:228464232 OBSCN 0.32 5.76 0.3 1.89e-8 Diastolic blood pressure; LUSC cis rs66679842 1 rs66679842 chr6:88171407 AC/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.4 -6.24 -0.32 1.34e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg18252515 chr7:66147081 NA 1.24 14.21 0.61 3.56e-36 Diabetic kidney disease; LUSC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg18681998 chr4:17616180 MED28 0.88 17.22 0.69 5.12e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs34779708 0.931 rs4934709 chr10:35339324 A/C cg03585969 chr10:35415529 CREM -0.57 -8.36 -0.42 1.73e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1790761 0.554 rs12787511 chr11:67401635 G/C cg14500267 chr11:67383377 NA -0.35 -6.13 -0.32 2.41e-9 Mean corpuscular volume; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg02951883 chr7:2050386 MAD1L1 -0.4 -7.01 -0.36 1.31e-11 Bipolar disorder and schizophrenia; LUSC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg24675056 chr1:15929824 NA 0.45 7.77 0.39 1.01e-13 Systolic blood pressure; LUSC cis rs10883723 0.810 rs12162 chr10:104240498 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.7 8.33 0.41 2.17e-15 Allergic disease (asthma, hay fever or eczema); LUSC cis rs453301 0.682 rs2929308 chr8:9084121 T/A cg15556689 chr8:8085844 FLJ10661 -0.62 -9.56 -0.46 2.76e-19 Joint mobility (Beighton score); LUSC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg21854759 chr1:92012499 NA -0.53 -8.95 -0.44 2.58e-17 Breast cancer; LUSC cis rs2835872 0.758 rs8134288 chr21:39036989 T/C cg20424643 chr21:39039972 KCNJ6 -0.44 -7.43 -0.38 8.98e-13 Electroencephalographic traits in alcoholism; LUSC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg09165964 chr15:75287851 SCAMP5 -1.01 -15.29 -0.64 2.16e-40 Blood trace element (Zn levels); LUSC trans rs9929218 0.551 rs1886697 chr16:68716179 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.1 27.1 0.83 2.38e-86 Colorectal cancer; LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.43e-14 Prudent dietary pattern; LUSC cis rs11048434 0.736 rs12424026 chr12:9110993 T/C cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.07 0.4 1.27e-14 Axial length; LUSC cis rs12594515 0.967 rs67854274 chr15:45990518 A/G cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg22166914 chr1:53195759 ZYG11B 0.56 9.26 0.45 2.64e-18 Monocyte count; LUSC cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg01448562 chr3:133502909 NA 0.59 9.3 0.45 1.82e-18 Alcohol consumption (transferrin glycosylation); LUSC cis rs11997175 0.598 rs4599769 chr8:33601425 T/C ch.8.33884649F chr8:33765107 NA 0.42 6.63 0.34 1.38e-10 Body mass index; LUSC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg06740227 chr12:86229804 RASSF9 -0.36 -5.7 -0.3 2.61e-8 Major depressive disorder; LUSC cis rs1957429 0.808 rs9783609 chr14:65352282 A/G cg23373153 chr14:65346875 NA 1.06 12.75 0.57 1.36e-30 Pediatric areal bone mineral density (radius); LUSC cis rs7197653 0.748 rs2279538 chr16:68397106 C/G cg09835421 chr16:68378352 PRMT7 -0.77 -8.61 -0.43 3.01e-16 Magnesium levels; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg07677032 chr17:61819896 STRADA 0.52 8.85 0.44 5.18e-17 Prudent dietary pattern; LUSC cis rs7312933 0.612 rs10785334 chr12:42620377 A/G cg01256987 chr12:42539512 GXYLT1 0.41 7.26 0.37 2.74e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6120849 0.615 rs11167248 chr20:33538721 G/T cg24642439 chr20:33292090 TP53INP2 0.62 7.08 0.36 8.72e-12 Protein C levels; LUSC cis rs1595825 0.891 rs75163179 chr2:198895402 G/A cg00982548 chr2:198649783 BOLL -0.54 -6.84 -0.35 3.78e-11 Ulcerative colitis; LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg10862848 chr6:42927986 GNMT 0.27 6.53 0.34 2.45e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg11764359 chr7:65958608 NA 0.55 7.32 0.37 1.86e-12 Aortic root size; LUSC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg21285383 chr16:89894308 SPIRE2 0.33 6.98 0.36 1.63e-11 Vitiligo; LUSC cis rs62408225 1.000 rs62408237 chr6:90980345 C/G cg06866423 chr6:90926672 BACH2 0.41 5.92 0.31 7.99e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg22903657 chr4:1355424 KIAA1530 -0.35 -5.68 -0.3 2.93e-8 Obesity-related traits; LUSC cis rs4654899 0.802 rs57351360 chr1:21229538 T/A cg01072550 chr1:21505969 NA -0.48 -7.01 -0.36 1.33e-11 Superior frontal gyrus grey matter volume; LUSC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg08470875 chr2:26401718 FAM59B 0.65 8.3 0.41 2.67e-15 Gut microbiome composition (summer); LUSC cis rs950776 0.642 rs7178007 chr15:78965254 G/A cg06917634 chr15:78832804 PSMA4 0.5 7.04 0.36 1.09e-11 Sudden cardiac arrest; LUSC cis rs62400317 0.826 rs12194682 chr6:45320520 T/A cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.35e-12 Total body bone mineral density; LUSC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg13770153 chr20:60521292 NA 0.45 6.44 0.33 4.19e-10 Body mass index; LUSC cis rs208520 0.690 rs851467 chr6:66802721 A/G cg07460842 chr6:66804631 NA -1.14 -18.17 -0.71 8.4e-52 Exhaled nitric oxide output; LUSC cis rs3924048 0.574 rs3923904 chr1:12616535 T/C cg00291366 chr1:12616550 NA 0.39 10.01 0.48 8.2e-21 Optic cup area; LUSC cis rs4964805 0.913 rs12229276 chr12:104204771 G/T cg02344784 chr12:104178138 NT5DC3 -0.45 -7.34 -0.37 1.63e-12 Attention deficit hyperactivity disorder; LUSC cis rs614226 1.000 rs563920 chr12:121017439 A/G cg01236616 chr12:121019343 POP5 1.31 21.22 0.76 7.27e-64 Type 1 diabetes nephropathy; LUSC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg00166722 chr3:10149974 C3orf24 0.54 7.43 0.38 8.88e-13 Alzheimer's disease; LUSC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03517284 chr6:25882590 NA 0.43 7.28 0.37 2.47e-12 Intelligence (multi-trait analysis); LUSC cis rs4906332 0.811 rs2296487 chr14:103996205 T/C cg04998671 chr14:104000505 TRMT61A -0.57 -7.81 -0.39 7.67e-14 Coronary artery disease; LUSC cis rs17253792 0.822 rs76264681 chr14:56060447 T/C cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs4664308 0.935 rs58354887 chr2:160927112 C/T cg03641300 chr2:160917029 PLA2R1 -0.69 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg17554472 chr22:41940697 POLR3H -0.48 -5.76 -0.3 1.89e-8 Vitiligo; LUSC cis rs13064411 0.696 rs869343 chr3:113226705 C/T cg18753928 chr3:113234510 CCDC52 -0.51 -7.93 -0.4 3.26e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs10751667 0.666 rs7395823 chr11:942701 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.42 0.33 4.63e-10 Alzheimer's disease (late onset); LUSC cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.41 5.86 0.31 1.11e-8 Schizophrenia; LUSC cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs12677618 0.623 rs28506950 chr8:142261967 C/T cg27411547 chr8:142287226 NA -0.47 -7.98 -0.4 2.4e-14 Plateletcrit; LUSC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg24399712 chr22:39784796 NA -0.6 -10.94 -0.51 5.23e-24 Intelligence (multi-trait analysis); LUSC cis rs912057 0.671 rs1294417 chr6:6741932 T/C cg06612196 chr6:6737390 NA 0.58 11.4 0.53 1.23e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg19468946 chr17:37922297 IKZF3 -0.43 -6.89 -0.35 2.82e-11 Self-reported allergy; LUSC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg06544989 chr22:39130855 UNC84B -0.34 -5.87 -0.31 1.05e-8 Menopause (age at onset); LUSC cis rs6964587 0.869 rs7778667 chr7:91520816 C/G cg22709100 chr7:91322751 NA -0.39 -5.8 -0.3 1.56e-8 Breast cancer; LUSC cis rs968451 0.685 rs61616683 chr22:39755773 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.55 6.88 0.35 2.96e-11 Primary biliary cholangitis; LUSC cis rs921968 0.643 rs711186 chr2:219346102 A/G cg02176678 chr2:219576539 TTLL4 -0.64 -11.5 -0.53 5.36e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC cis rs250677 1.000 rs36080 chr5:148430451 A/G cg05026186 chr5:148520876 ABLIM3 -0.38 -6.07 -0.32 3.55e-9 Breast cancer; LUSC cis rs907683 0.546 rs1058261 chr2:220285309 C/T cg15015639 chr2:220282977 DES -0.31 -7.23 -0.37 3.27e-12 Resting heart rate; LUSC cis rs2251381 0.515 rs2832299 chr21:30749237 G/C cg08807101 chr21:30365312 RNF160 0.63 10.11 0.48 3.91e-21 Selective IgA deficiency; LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg24829409 chr8:58192753 C8orf71 -0.5 -6.1 -0.32 2.86e-9 Developmental language disorder (linguistic errors); LUSC cis rs17253792 0.822 rs79538158 chr14:56051365 G/T cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.81 0.3 1.45e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11822739 chr20:57251485 STX16 -0.7 -5.97 -0.31 6.01e-9 Cognitive performance; LUSC cis rs6840360 0.615 rs55932132 chr4:152463897 G/T cg22705602 chr4:152727874 NA -0.32 -6.49 -0.33 3.05e-10 Intelligence (multi-trait analysis); LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg16031515 chr1:205743344 RAB7L1 -0.3 -6.34 -0.33 7.5e-10 Menarche (age at onset); LUSC cis rs1729951 0.575 rs1654925 chr3:136690391 C/T cg12473912 chr3:136751656 NA -0.38 -6.68 -0.34 1.03e-10 Neuroticism; LUSC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4604732 0.536 rs7528219 chr1:247628307 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.78 0.35 5.42e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.83 11.4 0.53 1.22e-25 Schizophrenia; LUSC cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg09184832 chr6:79620586 NA -0.45 -7.31 -0.37 1.96e-12 Intelligence (multi-trait analysis); LUSC cis rs12681288 0.823 rs12681230 chr8:994422 G/A cg15309053 chr8:964076 NA 0.33 6.79 0.35 5.27e-11 Schizophrenia; LUSC cis rs7172677 0.737 rs4886669 chr15:75448181 C/T cg14664628 chr15:75095509 CSK -0.42 -5.8 -0.3 1.5e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.65 8.36 0.42 1.67e-15 Chronic sinus infection; LUSC cis rs9583531 0.509 rs12184676 chr13:111396484 A/G cg24331049 chr13:111365604 ING1 -0.57 -6.22 -0.32 1.48e-9 Coronary artery disease; LUSC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03934478 chr11:495069 RNH1 0.85 9.9 0.48 2e-20 Body mass index; LUSC cis rs9486719 0.948 rs11153059 chr6:97014537 T/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.98 -0.48 1.1e-20 Migraine;Coronary artery disease; LUSC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg07701084 chr6:150067640 NUP43 0.58 8.9 0.44 3.58e-17 Lung cancer; LUSC cis rs2243480 0.522 rs73150635 chr7:65972490 C/T cg18252515 chr7:66147081 NA -1.25 -8.41 -0.42 1.19e-15 Diabetic kidney disease; LUSC cis rs9905704 0.647 rs6503888 chr17:57028126 T/C cg12560992 chr17:57184187 TRIM37 0.58 9.29 0.45 1.99e-18 Testicular germ cell tumor; LUSC cis rs73198271 0.740 rs10105920 chr8:8648737 A/G cg01851573 chr8:8652454 MFHAS1 -0.53 -8.79 -0.43 8.03e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg22968622 chr17:43663579 NA -0.77 -11.68 -0.54 1.21e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs4595586 0.545 rs11611625 chr12:39387207 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs7100689 0.784 rs1972370 chr10:82127180 A/G cg01528321 chr10:82214614 TSPAN14 1.03 15.99 0.66 3.98e-43 Post bronchodilator FEV1; LUSC trans rs3942852 0.955 rs4752897 chr11:48136990 C/T cg15704280 chr7:45808275 SEPT13 -0.51 -5.98 -0.31 5.88e-9 Acute lymphoblastic leukemia (childhood); LUSC trans rs1728785 1.000 rs7118 chr16:68600855 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.66 8.49 0.42 7.08e-16 Ulcerative colitis; LUSC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg23422044 chr7:1970798 MAD1L1 -0.59 -6.66 -0.34 1.11e-10 Bipolar disorder; LUSC cis rs5758659 1.000 rs134869 chr22:42652074 G/A cg15557168 chr22:42548783 NA -0.43 -7.21 -0.37 3.71e-12 Cognitive function; LUSC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg07041428 chr4:1763019 NA 0.36 5.75 0.3 2.06e-8 Bladder cancer;Urinary bladder cancer; LUSC cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -8.21 -0.41 4.93e-15 Schizophrenia; LUSC cis rs7633770 0.805 rs11710264 chr3:46661579 T/C cg11219411 chr3:46661640 NA 0.49 10.34 0.49 6.45e-22 Coronary artery disease; LUSC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg08470875 chr2:26401718 FAM59B -0.65 -8.72 -0.43 1.32e-16 Gut microbiome composition (summer); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15988734 chr14:103411822 CDC42BPB -0.7 -6.04 -0.31 4.03e-9 Cognitive performance; LUSC cis rs2486288 0.587 rs12899942 chr15:45547280 T/C cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.76 -0.51 2.15e-23 Glomerular filtration rate; LUSC cis rs2078087 0.522 rs539443 chr1:183215457 T/C cg13843938 chr1:183241246 NMNAT2 0.41 6.77 0.35 5.85e-11 Obesity-related traits; LUSC trans rs9329221 0.662 rs34155841 chr8:10247529 T/G cg15556689 chr8:8085844 FLJ10661 0.65 9.33 0.45 1.56e-18 Neuroticism; LUSC trans rs5756813 0.754 rs11089854 chr22:38148882 G/A cg19894588 chr14:64061835 NA -0.56 -7.51 -0.38 5.41e-13 Optic cup area;Vertical cup-disc ratio; LUSC cis rs2898681 0.528 rs73814883 chr4:53728054 G/C cg21521518 chr4:53727714 RASL11B 0.51 6.24 0.32 1.36e-9 Optic nerve measurement (cup area); LUSC cis rs2692947 0.696 rs2969490 chr2:96803904 A/G cg22654517 chr2:96458247 NA 0.37 7.48 0.38 6.82e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg24110177 chr3:50126178 RBM5 0.65 10.99 0.52 3.41e-24 Body mass index; LUSC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg23172400 chr8:95962367 TP53INP1 -0.45 -9.4 -0.46 8.89e-19 Type 2 diabetes; LUSC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg16339924 chr4:17578868 LAP3 0.59 9.2 0.45 3.85e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.85 0.66 1.36e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg07677032 chr17:61819896 STRADA 0.54 9.09 0.45 9.32e-18 Prudent dietary pattern; LUSC cis rs1790761 0.692 rs1269981 chr11:67334959 G/A cg14500267 chr11:67383377 NA 0.34 6.43 0.33 4.37e-10 Mean corpuscular volume; LUSC cis rs9811920 0.838 rs12488245 chr3:99835254 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.37 6.86 0.35 3.44e-11 Axial length; LUSC cis rs372883 0.506 rs2832300 chr21:30749315 A/G cg08807101 chr21:30365312 RNF160 0.62 9.93 0.48 1.59e-20 Pancreatic cancer; LUSC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.31 0.37 1.98e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg13393036 chr8:95962371 TP53INP1 -0.31 -5.98 -0.31 5.89e-9 Type 2 diabetes; LUSC cis rs838147 0.508 rs507711 chr19:49208564 C/T cg21064579 chr19:49206444 FUT2 0.44 8.35 0.42 1.87e-15 Dietary macronutrient intake; LUSC cis rs1595825 0.838 rs7603283 chr2:198517592 A/G cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.32e-10 Ulcerative colitis; LUSC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg05084668 chr3:125655381 ALG1L -0.48 -6.79 -0.35 5.17e-11 Blood pressure (smoking interaction); LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.62 -7.96 -0.4 2.76e-14 Systemic lupus erythematosus; LUSC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg17252645 chr8:143867129 LY6D 0.38 6.7 0.34 8.75e-11 Urinary tract infection frequency; LUSC cis rs7615952 0.515 rs4441610 chr3:125681307 C/G cg05084668 chr3:125655381 ALG1L -0.63 -9.99 -0.48 1e-20 Blood pressure (smoking interaction); LUSC cis rs11650494 0.908 rs73340399 chr17:47372743 G/C cg08112188 chr17:47440006 ZNF652 1.18 10.16 0.49 2.53e-21 Prostate cancer; LUSC cis rs11645898 0.622 rs4788463 chr16:72223716 G/T cg14768367 chr16:72042858 DHODH -0.57 -6.16 -0.32 2.13e-9 Blood protein levels; LUSC cis rs3790645 0.874 rs9438508 chr1:26893069 T/C cg17456097 chr1:26900765 RPS6KA1 0.42 6.08 0.32 3.36e-9 Glucose homeostasis traits; LUSC trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg15556689 chr8:8085844 FLJ10661 0.54 8.45 0.42 9.29e-16 Neuroticism; LUSC cis rs9747201 1.000 rs56051385 chr17:80126712 T/C cg18209359 chr17:80159595 CCDC57 0.4 6.61 0.34 1.52e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1801251 0.727 rs13029336 chr2:233569935 A/G cg25237894 chr2:233734115 C2orf82 -0.3 -5.69 -0.3 2.71e-8 Coronary artery disease; LUSC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg01503450 chr10:980765 NA -0.4 -5.81 -0.3 1.45e-8 Eosinophil percentage of granulocytes; LUSC cis rs10761482 0.861 rs2061486 chr10:62105916 A/G cg18175470 chr10:62150864 ANK3 -0.49 -7.11 -0.36 7.29e-12 Schizophrenia; LUSC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg18876405 chr7:65276391 NA -0.54 -8.6 -0.43 3.17e-16 Aortic root size; LUSC cis rs9527 0.641 rs10786732 chr10:104762535 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.4 -0.33 5.4e-10 Arsenic metabolism; LUSC cis rs68170813 0.559 rs17427123 chr7:106823661 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.67 -0.47 1.2e-19 Coronary artery disease; LUSC cis rs11123610 0.679 rs34705357 chr2:3716032 C/T cg00999904 chr2:3704751 ALLC -0.38 -6.35 -0.33 7.21e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs868036 0.681 rs28670272 chr15:68109907 C/T cg24579218 chr15:68104479 NA 0.35 6.24 0.32 1.32e-9 Restless legs syndrome; LUSC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.05e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.13e-12 Mean platelet volume; LUSC cis rs11971779 0.616 rs1133068 chr7:139053143 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs9329221 0.710 rs11785061 chr8:10259528 G/C cg21775007 chr8:11205619 TDH 0.44 5.79 0.3 1.63e-8 Neuroticism; LUSC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg02487422 chr3:49467188 NICN1 0.48 7.63 0.39 2.46e-13 Resting heart rate; LUSC cis rs4631830 0.863 rs57263518 chr10:51519154 A/G cg10326726 chr10:51549505 MSMB -0.35 -5.9 -0.31 8.86e-9 Prostate-specific antigen levels; LUSC cis rs4478858 0.647 rs6425720 chr1:31709555 A/G cg00250761 chr1:31883323 NA -0.34 -8.26 -0.41 3.37e-15 Alcohol dependence; LUSC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.54e-11 Extrinsic epigenetic age acceleration; LUSC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg18681998 chr4:17616180 MED28 0.83 15.19 0.64 5.34e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23249336 chr13:47127304 LRCH1 0.45 6.04 0.31 4.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg11663144 chr21:46675770 NA -0.35 -5.75 -0.3 2.05e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs17815608 1.000 rs17759214 chr12:77399915 T/C cg18631743 chr22:20104954 RANBP1;TRMT2A 0.56 6.46 0.33 3.68e-10 Type 2 diabetes; LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.44 7.01 0.36 1.36e-11 Bipolar disorder; LUSC cis rs1163251 0.902 rs640195 chr1:120217650 T/A cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC cis rs4722404 0.592 rs6461820 chr7:3118246 T/C cg19214707 chr7:3157722 NA -0.36 -6.0 -0.31 5.13e-9 Atopic dermatitis; LUSC trans rs62055045 0.528 rs62056195 chr16:71549485 A/G cg15281710 chr15:96890452 NA -0.5 -7.1 -0.36 7.77e-12 Schizophrenia; LUSC cis rs950776 0.714 rs615470 chr15:78885988 T/C cg06917634 chr15:78832804 PSMA4 -0.69 -11.31 -0.53 2.57e-25 Sudden cardiac arrest; LUSC trans rs9291683 0.509 rs10939671 chr4:10050815 T/C cg26043149 chr18:55253948 FECH 0.48 7.16 0.36 5.16e-12 Bone mineral density; LUSC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg02896835 chr1:92012615 NA -0.46 -6.48 -0.33 3.31e-10 Eosinophil percentage of white cells; LUSC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -11.64 -0.54 1.6e-26 Systemic lupus erythematosus; LUSC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs2078087 0.568 rs779153 chr1:183233018 A/G cg13843938 chr1:183241246 NMNAT2 -0.43 -7.01 -0.36 1.36e-11 Obesity-related traits; LUSC cis rs9660992 1.000 rs3851296 chr1:205253839 A/C cg00857998 chr1:205179979 DSTYK 0.46 6.88 0.35 3e-11 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg09085632 chr11:111637200 PPP2R1B 0.97 14.27 0.62 2.18e-36 Primary sclerosing cholangitis; LUSC cis rs7267979 0.966 rs2257461 chr20:25265554 A/G cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.56e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs694739 0.536 rs671976 chr11:64046029 G/A cg02228329 chr11:64053129 BAD;GPR137 0.4 6.3 0.33 9.5e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg19539972 chr4:7069911 GRPEL1 0.69 8.38 0.42 1.45e-15 Monocyte percentage of white cells; LUSC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg14829360 chr17:73884958 NA 0.35 5.88 0.31 9.75e-9 White matter hyperintensity burden; LUSC cis rs9952991 0.883 rs2847260 chr18:12775591 C/T cg23598886 chr18:12777645 NA 0.65 6.58 0.34 1.83e-10 Inflammatory skin disease; LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg08280861 chr8:58055591 NA 0.52 5.7 0.3 2.58e-8 Developmental language disorder (linguistic errors); LUSC cis rs7512552 0.803 rs59898460 chr1:150493004 T/C cg15654264 chr1:150340011 RPRD2 0.6 9.71 0.47 8.82e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg24450063 chr1:156163899 SLC25A44 1.06 17.08 0.68 1.85e-47 Testicular germ cell tumor; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17010941 chr8:102218219 ZNF706 -0.43 -6.61 -0.34 1.48e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs16910800 1.000 rs11027021 chr11:23183529 C/T cg20040320 chr11:23191996 NA 0.46 6.74 0.35 7.06e-11 Cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20342374 chr4:140005160 ELF2 -0.46 -5.98 -0.31 5.83e-9 Hepatitis; LUSC cis rs6445967 0.530 rs12634132 chr3:58409082 A/G cg23715586 chr3:58305044 RPP14 0.42 7.14 0.36 5.81e-12 Platelet count; LUSC trans rs1486139 1.000 rs10258322 chr7:46261337 T/C cg17534202 chr9:96721102 NA -0.35 -6.15 -0.32 2.26e-9 Select biomarker traits; LUSC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs2294015 1.000 rs2294015 chr8:124696867 C/T cg07200421 chr8:124693396 ANXA13 0.29 5.9 0.31 8.71e-9 Event-related brain oscillations; LUSC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg07636037 chr3:49044803 WDR6 -0.66 -8.47 -0.42 7.89e-16 Menarche (age at onset); LUSC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg09703963 chr11:616879 IRF7;MUPCDH -0.45 -7.33 -0.37 1.76e-12 Systemic lupus erythematosus; LUSC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg02896835 chr1:92012615 NA -0.67 -12.54 -0.57 8e-30 Breast cancer; LUSC cis rs636291 0.517 rs55935829 chr1:10540926 A/T cg17425144 chr1:10567563 PEX14 0.62 12.49 0.56 1.18e-29 Prostate cancer; LUSC cis rs892961 1.000 rs11077907 chr17:75400706 G/A cg05865280 chr17:75406074 SEPT9 0.41 8.37 0.42 1.61e-15 Airflow obstruction; LUSC cis rs8060686 0.641 rs2418737 chr16:68122726 T/C cg04539111 chr16:67997858 SLC12A4 -0.41 -5.83 -0.3 1.31e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs977987 0.933 rs1834014 chr16:75501274 G/A cg03315344 chr16:75512273 CHST6 0.57 10.83 0.51 1.26e-23 Dupuytren's disease; LUSC cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg21466736 chr12:48725269 NA -0.33 -5.76 -0.3 1.92e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs3093024 0.839 rs968334 chr6:167526096 T/C cg07741184 chr6:167504864 NA -0.49 -8.45 -0.42 9.1e-16 Rheumatoid arthritis; LUSC cis rs1775715 0.707 rs1541262 chr10:32179771 A/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.65 0.34 1.22e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg16447950 chr5:562315 NA -0.53 -6.95 -0.36 1.87e-11 Obesity-related traits; LUSC cis rs73198271 0.740 rs10092600 chr8:8649023 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.02 -0.31 4.67e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs34779708 0.702 rs4007272 chr10:35546859 T/G cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg00990874 chr7:1149470 C7orf50 -0.49 -6.07 -0.32 3.38e-9 Bronchopulmonary dysplasia; LUSC trans rs3857536 0.813 rs7757647 chr6:66947207 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -7.86 -0.39 5.47e-14 Tuberculosis; LUSC cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg05234568 chr11:5960015 NA 0.55 7.54 0.38 4.35e-13 DNA methylation (variation); LUSC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg21972741 chr5:435613 AHRR 0.32 5.76 0.3 1.92e-8 Cystic fibrosis severity; LUSC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 14.11 0.61 8.82e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3845702 1.000 rs10497555 chr2:180864967 A/G cg01881094 chr2:180872142 CWC22 0.8 10.31 0.49 8.34e-22 Schizophrenia; LUSC cis rs5769765 1.000 rs768618 chr22:50286827 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.81 -10.8 -0.51 1.64e-23 Schizophrenia; LUSC cis rs72781680 1.000 rs75046532 chr2:24167267 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13596040 chr4:37828581 PGM2 0.69 6.15 0.32 2.17e-9 Cognitive performance; LUSC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg22903471 chr2:27725779 GCKR 0.43 7.42 0.38 1.01e-12 Total body bone mineral density; LUSC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg24531977 chr5:56204891 C5orf35 -1.17 -19.23 -0.72 5.36e-56 Initial pursuit acceleration; LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg00149659 chr3:10157352 C3orf10 0.99 14.08 0.61 1.17e-35 Alzheimer's disease; LUSC cis rs10208940 0.920 rs6751531 chr2:68794528 G/T cg12452813 chr2:68675892 NA 0.57 5.92 0.31 7.99e-9 Urate levels in lean individuals; LUSC cis rs67460515 0.563 rs9883566 chr3:160770323 C/T cg03342759 chr3:160939853 NMD3 0.4 5.76 0.3 1.89e-8 Parkinson's disease; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.27 0.37 2.52e-12 Bipolar disorder; LUSC cis rs116095464 0.558 rs10059907 chr5:205360 G/C cg22857025 chr5:266934 NA -1.19 -13.86 -0.6 7.97e-35 Breast cancer; LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg02175503 chr12:58329896 NA 0.59 9.04 0.44 1.31e-17 Intelligence (multi-trait analysis); LUSC cis rs7512552 0.780 rs55823828 chr1:150467296 G/C cg15654264 chr1:150340011 RPRD2 0.62 10.17 0.49 2.32e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs6456156 0.774 rs1556413 chr6:167524743 G/A cg07741184 chr6:167504864 NA -0.34 -5.99 -0.31 5.54e-9 Primary biliary cholangitis; LUSC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg18681998 chr4:17616180 MED28 0.84 15.62 0.65 1.13e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg21535247 chr6:8435926 SLC35B3 0.57 9.02 0.44 1.5e-17 Motion sickness; LUSC cis rs7572644 0.656 rs10196483 chr2:28221182 A/T cg27432699 chr2:27873401 GPN1 -0.49 -6.14 -0.32 2.39e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11640436 0.565 rs2162957 chr16:77297193 C/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.37 5.8 0.3 1.52e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg18352616 chr4:3374830 RGS12 0.34 6.76 0.35 6.06e-11 Serum sulfate level; LUSC cis rs1545257 0.537 rs11125583 chr2:24646278 C/A cg06627628 chr2:24431161 ITSN2 -0.4 -5.66 -0.3 3.27e-8 Sjögren's syndrome; LUSC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.05e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs877282 0.700 rs816311 chr10:796490 C/A cg17470449 chr10:769945 NA 0.4 6.05 0.31 3.84e-9 Uric acid levels; LUSC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg00310523 chr12:86230176 RASSF9 0.43 7.72 0.39 1.38e-13 Major depressive disorder; LUSC cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.66 0.65 7.82e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.4 0.38 1.15e-12 Schizophrenia; LUSC cis rs3540 0.512 rs3862437 chr15:91084632 A/G cg10434728 chr15:90938212 IQGAP1 -0.46 -9.47 -0.46 5.36e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7180079 1.000 rs1533378 chr15:64646777 A/G cg08069370 chr15:64387884 SNX1 -0.53 -5.85 -0.3 1.19e-8 Monocyte count; LUSC cis rs1322512 0.917 rs2623948 chr6:152963087 C/T cg27316956 chr6:152958899 SYNE1 -0.37 -6.32 -0.33 8.6e-10 Tonometry; LUSC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg07936489 chr17:37558343 FBXL20 -0.71 -10.08 -0.48 4.97e-21 Glomerular filtration rate (creatinine); LUSC cis rs1790761 0.632 rs625978 chr11:67344664 C/T cg00864171 chr11:67383662 NA 0.35 6.19 0.32 1.81e-9 Mean corpuscular volume; LUSC cis rs9473147 0.516 rs6903331 chr6:47562915 A/G cg02130027 chr6:47444894 CD2AP 0.35 5.76 0.3 1.92e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs78572108 0.858 rs4952582 chr2:42268672 C/T cg00607755 chr2:42274082 PKDCC 0.35 5.98 0.31 5.72e-9 Total body bone mineral density; LUSC cis rs73416724 1.000 rs74690967 chr6:43370915 C/T cg26312998 chr6:43337775 ZNF318 0.53 6.2 0.32 1.68e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs12210905 0.688 rs75968505 chr6:27476996 T/C cg08851530 chr6:28072375 NA 0.95 6.15 0.32 2.21e-9 Hip circumference adjusted for BMI; LUSC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs9399401 0.732 rs9389996 chr6:142826771 G/A cg03128060 chr6:142623767 GPR126 0.31 5.7 0.3 2.58e-8 Chronic obstructive pulmonary disease; LUSC cis rs8078723 0.677 rs8073254 chr17:38149350 C/G cg17467752 chr17:38218738 THRA -0.71 -11.37 -0.53 1.55e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg12927641 chr6:109611667 NA -0.36 -6.09 -0.32 3.05e-9 Reticulocyte fraction of red cells; LUSC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.04 0.4 1.62e-14 Parkinson's disease; LUSC cis rs7829975 0.684 rs546603 chr8:8595838 T/G cg15556689 chr8:8085844 FLJ10661 -0.58 -8.66 -0.43 2.09e-16 Mood instability; LUSC cis rs2219968 0.828 rs1486923 chr8:78883445 T/C cg00738934 chr8:78996279 NA -0.39 -6.93 -0.35 2.16e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.93 0.31 7.75e-9 Menopause (age at onset); LUSC trans rs800082 0.690 rs2575191 chr3:144279228 G/A cg24215973 chr2:240111563 HDAC4 0.61 9.63 0.47 1.54e-19 Smoking behavior; LUSC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg20406979 chr6:167373233 NA 0.25 5.99 0.31 5.28e-9 Crohn's disease; LUSC cis rs983392 0.679 rs1019671 chr11:60008151 T/C cg24026212 chr11:59952134 MS4A6A -0.34 -5.7 -0.3 2.63e-8 Alzheimer's disease (late onset); LUSC cis rs10832963 1.000 rs10832962 chr11:18656271 C/T cg09201001 chr11:18656081 SPTY2D1 0.92 15.18 0.64 6.23e-40 Breast cancer; LUSC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg07701084 chr6:150067640 NUP43 0.53 8.14 0.41 7.72e-15 Lung cancer; LUSC cis rs259282 0.584 rs10416758 chr19:33107716 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.64 9.53 0.46 3.47e-19 Schizophrenia; LUSC cis rs662064 0.852 rs1411402 chr1:10579545 G/T cg20482658 chr1:10539492 PEX14 0.32 6.28 0.33 1.04e-9 Asthma; LUSC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05901451 chr6:126070800 HEY2 0.76 12.86 0.58 5.07e-31 Brugada syndrome; LUSC cis rs79149102 0.579 rs7342591 chr15:75306863 C/T cg09165964 chr15:75287851 SCAMP5 0.94 8.95 0.44 2.44e-17 Lung cancer; LUSC cis rs7945705 0.846 rs4929911 chr11:8816495 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.36 7.14 0.36 5.74e-12 Hemoglobin concentration; LUSC cis rs9393777 0.920 rs13195040 chr6:27413924 C/T cg09904177 chr6:26538194 HMGN4 0.76 6.04 0.31 4.16e-9 Intelligence (multi-trait analysis); LUSC cis rs2688608 0.967 rs2633299 chr10:75656754 T/G cg23231163 chr10:75533350 FUT11 -0.38 -6.23 -0.32 1.39e-9 Inflammatory bowel disease; LUSC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg19748678 chr4:122722346 EXOSC9 0.49 7.54 0.38 4.44e-13 Type 2 diabetes; LUSC cis rs4073416 0.518 rs10150412 chr14:65916791 C/T cg03016385 chr14:66212404 NA -0.41 -6.23 -0.32 1.39e-9 N-glycan levels; LUSC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg22903471 chr2:27725779 GCKR -0.41 -6.94 -0.35 2.1e-11 Total body bone mineral density; LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg13395646 chr4:1353034 KIAA1530 -0.65 -10.2 -0.49 1.85e-21 Obesity-related traits; LUSC cis rs11190604 0.943 rs11190588 chr10:102273565 C/T cg07080220 chr10:102295463 HIF1AN 0.68 8.77 0.43 9.44e-17 Palmitoleic acid (16:1n-7) levels; LUSC trans rs11098499 0.863 rs1480939 chr4:120456927 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg27279351 chr12:120934652 DYNLL1 0.63 8.41 0.42 1.21e-15 High light scatter reticulocyte count; LUSC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg08847533 chr14:75593920 NEK9 -0.84 -15.12 -0.64 9.89e-40 Height; LUSC cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg21385522 chr1:16154831 NA 0.52 7.82 0.39 7.04e-14 Systolic blood pressure; LUSC cis rs7107174 1.000 rs1385601 chr11:77936064 A/C cg02023728 chr11:77925099 USP35 0.49 7.2 0.37 4.01e-12 Testicular germ cell tumor; LUSC cis rs7927592 0.546 rs683978 chr11:68192421 T/C cg01657329 chr11:68192670 LRP5 -0.47 -7.12 -0.36 6.83e-12 Total body bone mineral density; LUSC cis rs6964587 0.626 rs404 chr7:91544316 G/T cg17063962 chr7:91808500 NA -0.55 -8.87 -0.44 4.46e-17 Breast cancer; LUSC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg05368731 chr17:41323189 NBR1 -0.84 -14.37 -0.62 8.92e-37 Menopause (age at onset); LUSC cis rs864537 0.646 rs2995091 chr1:167434277 T/C cg22356347 chr1:167427500 CD247 -0.35 -8.38 -0.42 1.49e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg08280861 chr8:58055591 NA 0.54 5.89 0.31 9.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs1865760 0.508 rs9379820 chr6:26049924 T/C cg16482183 chr6:26056742 HIST1H1C 0.53 7.81 0.39 7.32e-14 Height; LUSC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs11264799 0.603 rs11799853 chr1:157557957 T/C cg18268488 chr1:157545234 FCRL4 0.33 5.86 0.31 1.11e-8 IgA nephropathy; LUSC cis rs7512552 0.803 rs7513205 chr1:150472781 A/G cg15654264 chr1:150340011 RPRD2 0.64 10.58 0.5 9.39e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs60843830 1.000 rs60843830 chr2:286756 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.54 7.66 0.39 2.04e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg22618164 chr12:122356400 WDR66 0.64 9.47 0.46 5.45e-19 Mean corpuscular volume; LUSC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg27398817 chr8:82754497 SNX16 -0.46 -6.12 -0.32 2.56e-9 Diastolic blood pressure; LUSC trans rs7824557 0.603 rs11250130 chr8:11214455 C/T cg06636001 chr8:8085503 FLJ10661 -0.57 -8.64 -0.43 2.4e-16 Retinal vascular caliber; LUSC cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg05472934 chr7:22766657 IL6 -0.57 -8.02 -0.4 1.75e-14 Lung cancer; LUSC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg22875332 chr1:76189707 ACADM 0.82 14.56 0.62 1.52e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg27129171 chr3:47204927 SETD2 0.76 13.55 0.6 1.28e-33 Colorectal cancer; LUSC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.74 -9.17 -0.45 5.12e-18 Gut microbiome composition (summer); LUSC cis rs6700559 0.740 rs6663322 chr1:200649869 G/A cg07804481 chr1:200639085 DDX59 0.4 5.76 0.3 1.94e-8 Coronary artery disease; LUSC cis rs1801251 1.000 rs6747645 chr2:233571033 C/T cg08000102 chr2:233561755 GIGYF2 -0.67 -11.26 -0.52 3.67e-25 Coronary artery disease; LUSC trans rs2243480 1.000 rs35283677 chr7:65359233 C/T cg10756647 chr7:56101905 PSPH 0.88 8.45 0.42 8.8e-16 Diabetic kidney disease; LUSC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg06505273 chr16:24850292 NA 0.41 5.67 0.3 3.16e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2274273 0.773 rs8012380 chr14:55735010 T/G cg04306507 chr14:55594613 LGALS3 0.57 13.56 0.6 1.14e-33 Protein biomarker; LUSC cis rs2760061 0.626 rs2527615 chr1:228119283 A/G cg18477163 chr1:228402036 OBSCN -0.57 -10.55 -0.5 1.18e-22 Diastolic blood pressure; LUSC cis rs2559856 1.000 rs2695291 chr12:102087543 G/A cg12924262 chr12:102091054 CHPT1 0.43 6.05 0.31 3.96e-9 Blood protein levels; LUSC trans rs2797160 1.000 rs1739374 chr6:126011825 C/T cg05039488 chr6:79577232 IRAK1BP1 0.44 6.59 0.34 1.7e-10 Endometrial cancer; LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.812 rs78342280 chr3:41948810 G/A cg03022575 chr3:42003672 ULK4 0.81 8.49 0.42 6.81e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.03 0.48 7.2e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg00152838 chr16:24741724 TNRC6A -0.46 -5.68 -0.3 2.92e-8 Intelligence (multi-trait analysis); LUSC trans rs11949289 0.967 rs4339359 chr5:28334807 A/T cg18220921 chr1:242687527 PLD5 0.35 6.05 0.31 3.9e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11785400 0.731 rs4644221 chr8:143736984 C/T cg10596483 chr8:143751796 JRK -0.53 -7.9 -0.4 4.07e-14 Schizophrenia; LUSC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg27121462 chr16:89883253 FANCA 0.55 8.95 0.44 2.54e-17 Vitiligo; LUSC cis rs7180079 0.620 rs11632113 chr15:65040445 T/G cg08069370 chr15:64387884 SNX1 0.52 5.72 0.3 2.32e-8 Monocyte count; LUSC cis rs96067 0.652 rs7553155 chr1:36568236 A/T cg27506609 chr1:36549197 TEKT2 0.63 8.75 0.43 1.05e-16 Corneal structure; LUSC cis rs6840360 1.000 rs6845944 chr4:152604520 C/T cg22705602 chr4:152727874 NA -0.28 -5.84 -0.3 1.22e-8 Intelligence (multi-trait analysis); LUSC cis rs3768617 0.510 rs7529465 chr1:183096880 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19021960 chr1:228291175 C1orf35 -0.43 -6.26 -0.32 1.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12681287 0.752 rs13277670 chr8:87259920 T/G cg27223183 chr8:87520930 FAM82B -0.47 -5.94 -0.31 7.1e-9 Caudate activity during reward; LUSC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg17330251 chr7:94953956 PON1 -0.36 -5.88 -0.31 9.79e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg18404041 chr3:52824283 ITIH1 0.6 10.32 0.49 7.46e-22 Schizophrenia; LUSC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg11764359 chr7:65958608 NA 0.71 10.7 0.51 3.64e-23 Aortic root size; LUSC cis rs6901250 1.000 rs6901250 chr6:117114025 A/G cg12892004 chr6:117198278 RFX6 -0.42 -7.86 -0.39 5.5e-14 C-reactive protein levels; LUSC cis rs11785400 1.000 rs6988393 chr8:143740596 A/G cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg13114125 chr14:105738426 BRF1 -0.95 -15.9 -0.66 9.24e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs6977660 0.652 rs4721826 chr7:19823804 T/C cg07541023 chr7:19748670 TWISTNB 0.6 6.37 0.33 6.35e-10 Thyroid stimulating hormone; LUSC cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg21545522 chr1:205238299 TMCC2 0.51 9.69 0.47 9.59e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg06481639 chr22:41940642 POLR3H -0.51 -6.22 -0.32 1.5e-9 Vitiligo; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg16325326 chr1:53192061 ZYG11B 0.78 14.03 0.61 1.72e-35 Monocyte count; LUSC cis rs2387326 0.717 rs10829337 chr10:129943548 T/C cg16087940 chr10:129947807 NA -0.39 -5.81 -0.3 1.48e-8 Select biomarker traits; LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18758796 chr5:131593413 PDLIM4 0.47 7.68 0.39 1.79e-13 Acylcarnitine levels; LUSC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg03732007 chr1:2071316 PRKCZ -0.6 -10.57 -0.5 1.03e-22 Height; LUSC cis rs9911578 1.000 rs9901114 chr17:56575208 G/A cg12560992 chr17:57184187 TRIM37 -0.82 -14.87 -0.63 9.48e-39 Intelligence (multi-trait analysis); LUSC cis rs2732480 0.500 rs2732461 chr12:48692802 C/A cg04545296 chr12:48745243 ZNF641 0.34 6.27 0.32 1.14e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs61931739 0.500 rs28692887 chr12:34457075 G/A cg06521331 chr12:34319734 NA -0.41 -6.33 -0.33 8.04e-10 Morning vs. evening chronotype; LUSC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg11247378 chr22:39784982 NA -0.66 -13.31 -0.59 1.03e-32 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6121246 0.520 rs6060425 chr20:30224355 C/T cg13852791 chr20:30311386 BCL2L1 0.84 10.19 0.49 2.01e-21 Mean corpuscular hemoglobin; LUSC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -8.17 -0.41 6.41e-15 Cystic fibrosis severity; LUSC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs9329221 0.935 rs3750311 chr8:10283602 C/A cg15556689 chr8:8085844 FLJ10661 -0.59 -8.89 -0.44 3.98e-17 Neuroticism; LUSC trans rs7980799 0.933 rs11052705 chr12:33588388 T/C cg26384229 chr12:38710491 ALG10B -0.45 -6.53 -0.34 2.39e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs11098499 0.754 rs7689729 chr4:120256192 A/G cg09307838 chr4:120376055 NA 0.69 10.47 0.5 2.2e-22 Corneal astigmatism; LUSC cis rs7100689 0.577 rs1417219 chr10:82041409 C/T cg00277334 chr10:82204260 NA -0.47 -6.61 -0.34 1.51e-10 Post bronchodilator FEV1; LUSC cis rs6012953 0.654 rs2206656 chr20:49130119 C/G cg13958625 chr20:49123093 NA 0.28 5.83 0.3 1.29e-8 Vitiligo; LUSC trans rs9393777 0.920 rs35869525 chr6:26946687 C/T cg06606381 chr12:133084897 FBRSL1 -0.89 -8.25 -0.41 3.62e-15 Intelligence (multi-trait analysis); LUSC cis rs6542838 0.641 rs4553869 chr2:99505940 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.67 -0.3 3.08e-8 Fear of minor pain; LUSC cis rs1355223 0.545 rs7106831 chr11:34879542 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.72 -0.35 7.65e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg12016809 chr21:47604291 C21orf56 0.4 6.02 0.31 4.57e-9 Testicular germ cell tumor; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.69 10.48 0.5 2.02e-22 Lymphocyte counts; LUSC cis rs12291225 0.753 rs1431374 chr11:14303975 T/C cg05501817 chr11:14380813 RRAS2 -0.57 -8.9 -0.44 3.5e-17 Sense of smell; LUSC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg03806693 chr22:41940476 POLR3H -0.89 -12.63 -0.57 3.75e-30 Vitiligo; LUSC cis rs7809950 1.000 rs2250414 chr7:107140987 T/G cg23024343 chr7:107201750 COG5 -0.55 -8.75 -0.43 1.07e-16 Coronary artery disease; LUSC trans rs11723530 0.538 rs4692761 chr4:170814074 T/C cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.28 -0.32 1.03e-9 Myopia (pathological); LUSC trans rs6852435 1.000 rs34421418 chr4:175306470 G/A cg23753247 chr11:8615842 STK33 -0.53 -5.97 -0.31 5.91e-9 Response to acetaminophen (hepatotoxicity); LUSC cis rs7202877 0.706 rs42472 chr16:75473320 T/A cg03315344 chr16:75512273 CHST6 -0.45 -6.46 -0.33 3.64e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs4851254 0.961 rs11680485 chr2:100749744 A/G cg07810366 chr2:100720526 AFF3 -0.37 -5.74 -0.3 2.08e-8 Intelligence (multi-trait analysis); LUSC cis rs7786808 0.536 rs4909210 chr7:158194376 T/C cg09998033 chr7:158218633 PTPRN2 -0.4 -6.35 -0.33 7.18e-10 Obesity-related traits; LUSC cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg17077180 chr1:38461687 NA 0.45 7.0 0.36 1.43e-11 Coronary artery disease; LUSC cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs8038465 0.662 rs7497012 chr15:73968719 G/A cg15420318 chr15:73925796 NPTN 0.56 9.23 0.45 3.29e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9467711 0.651 rs13197334 chr6:26122648 G/C cg08501292 chr6:25962987 TRIM38 0.64 5.84 0.3 1.24e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg12560992 chr17:57184187 TRIM37 0.84 15.44 0.65 5.6e-41 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg17376030 chr22:41985996 PMM1 -0.47 -5.9 -0.31 8.94e-9 Vitiligo; LUSC cis rs9399401 0.626 rs7756434 chr6:142775295 A/G cg03128060 chr6:142623767 GPR126 0.53 9.12 0.45 6.95e-18 Chronic obstructive pulmonary disease; LUSC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg13683864 chr3:40499215 RPL14 -1.14 -20.56 -0.75 2.88e-61 Renal cell carcinoma; LUSC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg00750074 chr16:89608354 SPG7 -0.45 -7.76 -0.39 1.01e-13 Multiple myeloma (IgH translocation); LUSC cis rs9560113 1.000 rs9560107 chr13:112180146 G/A cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.54e-13 Menarche (age at onset); LUSC cis rs1832871 0.521 rs62437410 chr6:158822888 G/C cg07165851 chr6:158734300 TULP4 0.38 6.1 0.32 2.9e-9 Height; LUSC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs950169 0.840 rs62019457 chr15:85102142 T/C cg17173187 chr15:85201210 NMB 0.37 6.68 0.34 1.03e-10 Schizophrenia; LUSC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg09703963 chr11:616879 IRF7;MUPCDH -0.52 -7.85 -0.39 5.77e-14 Systemic lupus erythematosus; LUSC cis rs6964587 1.000 rs12540055 chr7:91707921 A/G cg17063962 chr7:91808500 NA 0.57 9.15 0.45 5.75e-18 Breast cancer; LUSC trans rs12310956 0.527 rs10772117 chr12:33900096 C/T cg13010199 chr12:38710504 ALG10B 0.5 7.81 0.39 7.51e-14 Morning vs. evening chronotype; LUSC cis rs7605827 0.930 rs11688071 chr2:15612626 T/G cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.36e-16 Educational attainment (years of education); LUSC cis rs9355610 0.727 rs2247315 chr6:167370211 A/C cg23791538 chr6:167370224 RNASET2 0.54 9.07 0.44 1.01e-17 Graves' disease; LUSC cis rs7172677 1.000 rs4243032 chr15:75426884 C/G cg14664628 chr15:75095509 CSK -0.44 -5.81 -0.3 1.43e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs308447 0.516 rs13127908 chr4:123720933 G/C cg10495464 chr4:123653540 BBS12;LOC729338 0.83 11.33 0.53 2.2e-25 Perceived unattractiveness to mosquitoes; LUSC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg24531977 chr5:56204891 C5orf35 -0.98 -14.68 -0.63 5.64e-38 Initial pursuit acceleration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21815536 chr7:35840623 SEPT7 -0.48 -6.14 -0.32 2.35e-9 Bipolar disorder and schizophrenia; LUSC trans rs2204008 0.811 rs8189445 chr12:38276295 T/C cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.74e-9 Bladder cancer; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.4 0.56 2.7e-29 Prudent dietary pattern; LUSC cis rs113835537 0.735 rs519380 chr11:66409409 G/A cg24851651 chr11:66362959 CCS 0.56 8.42 0.42 1.11e-15 Airway imaging phenotypes; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.79 -0.39 8.83e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4891159 0.526 rs2848961 chr18:74129886 C/G cg24786174 chr18:74118243 ZNF516 -0.93 -20.2 -0.74 7.22e-60 Longevity; LUSC cis rs12579753 1.000 rs12366580 chr12:82222784 G/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.03 -0.31 4.24e-9 Resting heart rate; LUSC cis rs9395066 0.545 rs6925467 chr6:44998038 T/A cg25276700 chr6:44698697 NA 0.28 5.72 0.3 2.39e-8 Height; LUSC cis rs1009647 0.633 rs11626485 chr14:55826764 A/G cg04306507 chr14:55594613 LGALS3 0.44 6.1 0.32 2.89e-9 Testicular germ cell tumor; LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg09877947 chr5:131593287 PDLIM4 0.59 10.05 0.48 6.22e-21 Acylcarnitine levels; LUSC cis rs11585357 0.947 rs2977304 chr1:17611615 T/C cg08277548 chr1:17600880 PADI3 0.63 6.78 0.35 5.57e-11 Hair shape; LUSC cis rs240764 0.578 rs62422070 chr6:101260827 T/G cg09795085 chr6:101329169 ASCC3 0.44 6.23 0.32 1.4e-9 Neuroticism; LUSC cis rs11155671 0.530 rs9322228 chr6:150209309 C/G cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg03929089 chr4:120376271 NA -0.92 -14.71 -0.63 4.14e-38 Coronary artery disease; LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.13 0.64 9.03e-40 Platelet count; LUSC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg00933542 chr6:150070202 PCMT1 0.31 6.62 0.34 1.47e-10 Lung cancer; LUSC cis rs116095464 0.558 rs6879656 chr5:264428 T/C cg22496380 chr5:211416 CCDC127 -0.8 -8.86 -0.44 4.83e-17 Breast cancer; LUSC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg16049864 chr8:95962084 TP53INP1 -0.63 -11.7 -0.54 9.69e-27 Type 2 diabetes; LUSC cis rs1371867 0.846 rs2439458 chr8:101297984 T/C cg00191853 chr8:101177733 SPAG1 -0.39 -6.49 -0.33 3.19e-10 Atrioventricular conduction; LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg13882712 chr2:27603741 ZNF513 -0.4 -6.1 -0.32 2.87e-9 QT interval (ambient particulate matter interaction); LUSC cis rs727505 1.000 rs17246404 chr7:124462661 C/T cg23710748 chr7:124431027 NA -0.42 -7.46 -0.38 7.37e-13 Lewy body disease; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.77 0.3 1.77e-8 Menopause (age at onset); LUSC cis rs7759001 0.857 rs2393927 chr6:27348095 G/C cg18711553 chr6:27366782 ZNF391 0.4 5.81 0.3 1.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs1215050 0.740 rs804051 chr4:98935935 A/T cg03676636 chr4:99064102 C4orf37 -0.27 -5.77 -0.3 1.84e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6163 0.588 rs67506723 chr10:104509064 G/T cg04362960 chr10:104952993 NT5C2 0.46 6.86 0.35 3.38e-11 Waist circumference;Hip circumference; LUSC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11890956 chr21:40555474 PSMG1 1.0 17.59 0.69 1.69e-49 Cognitive function; LUSC cis rs34779708 0.931 rs34087268 chr10:35346724 T/G cg03585969 chr10:35415529 CREM 0.62 8.93 0.44 2.97e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4805272 0.512 rs8105613 chr19:29339151 C/T cg12667521 chr19:29218732 NA 0.52 6.07 0.32 3.41e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg22834771 chr12:69754056 YEATS4 -0.5 -7.4 -0.38 1.15e-12 Blood protein levels; LUSC cis rs7241530 0.662 rs55694606 chr18:75902149 A/G cg14642773 chr18:75888474 NA 0.41 6.27 0.32 1.14e-9 Educational attainment (years of education); LUSC cis rs734999 0.545 rs10752748 chr1:2544640 G/A cg18854424 chr1:2615690 NA 0.5 10.16 0.49 2.69e-21 Ulcerative colitis; LUSC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9911578 1.000 rs2055779 chr17:57030561 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.59 0.34 1.68e-10 Intelligence (multi-trait analysis); LUSC cis rs2742417 0.967 rs1883096 chr3:45750015 C/T cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.47e-13 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs60787346 0.883 rs3788070 chr21:45068077 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.24 0.32 1.29e-9 Coronary artery disease; LUSC cis rs9311676 0.632 rs11923181 chr3:58380569 A/C cg26110898 chr3:58419937 PDHB 0.41 6.72 0.35 7.94e-11 Systemic lupus erythematosus; LUSC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg20818283 chr2:191399100 TMEM194B 0.45 6.9 0.35 2.54e-11 Pulse pressure; LUSC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg24642844 chr7:1081250 C7orf50 -0.68 -9.68 -0.47 1.05e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11098499 0.954 rs7687843 chr4:120421211 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg17340268 chr14:105411764 AHNAK2 -0.4 -6.42 -0.33 4.76e-10 Rheumatoid arthritis; LUSC cis rs3808502 0.549 rs4841564 chr8:11425809 T/G cg21775007 chr8:11205619 TDH -0.54 -7.58 -0.38 3.55e-13 Neuroticism; LUSC cis rs559555 0.597 rs502139 chr2:31811268 T/C cg02381751 chr2:32503542 YIPF4 0.4 5.71 0.3 2.55e-8 Blood metabolite ratios;Blood metabolite levels; LUSC cis rs763121 0.524 rs760645 chr22:39032270 C/T cg06022373 chr22:39101656 GTPBP1 0.45 6.33 0.33 7.87e-10 Menopause (age at onset); LUSC cis rs1348850 0.793 rs13000048 chr2:178337089 C/A cg22681709 chr2:178499509 PDE11A -0.51 -9.34 -0.46 1.4e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7954584 0.531 rs6486781 chr12:122318985 A/C cg13699009 chr12:122356056 WDR66 0.48 7.36 0.37 1.47e-12 Mean corpuscular volume; LUSC cis rs6087990 0.899 rs1003521 chr20:31366598 T/C cg13636640 chr20:31349939 DNMT3B 1.0 22.4 0.77 1.62e-68 Ulcerative colitis; LUSC cis rs17125944 0.556 rs7152229 chr14:53313405 T/C cg00686598 chr14:53173677 PSMC6 -0.61 -5.64 -0.3 3.54e-8 Alzheimer's disease (late onset); LUSC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg18876405 chr7:65276391 NA 0.75 13.67 0.6 4.47e-34 Aortic root size; LUSC cis rs7584330 0.704 rs7598954 chr2:238364776 C/T cg16989719 chr2:238392110 NA -0.45 -7.25 -0.37 2.85e-12 Prostate cancer; LUSC cis rs1559088 0.948 rs2019603 chr19:33577367 C/T cg27124370 chr19:33622961 WDR88 -0.57 -7.67 -0.39 1.89e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7674212 0.570 rs6813563 chr4:104099110 G/A cg16532752 chr4:104119610 CENPE -0.48 -6.91 -0.35 2.4e-11 Type 2 diabetes; LUSC cis rs921665 0.831 rs12476669 chr2:3195428 A/T cg02624386 chr2:3182749 NA 0.56 5.74 0.3 2.12e-8 World class endurance athleticism; LUSC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg07741184 chr6:167504864 NA -0.4 -7.13 -0.36 6.36e-12 Crohn's disease; LUSC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7703051 0.901 rs5744680 chr5:74879890 C/T cg06933384 chr5:74808293 COL4A3BP;POLK 0.37 5.96 0.31 6.45e-9 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08971981 chr7:44163271 POLD2 -0.56 -6.59 -0.34 1.75e-10 Bipolar disorder and schizophrenia; LUSC cis rs9535307 0.929 rs7984061 chr13:50337340 G/A cg04663916 chr13:50265991 EBPL 0.52 5.7 0.3 2.64e-8 Obesity-related traits; LUSC cis rs9303401 0.659 rs12150536 chr17:56640834 C/T cg25039879 chr17:56429692 SUPT4H1 0.66 8.83 0.44 6e-17 Cognitive test performance; LUSC cis rs11758351 1.000 rs111596617 chr6:26191678 A/T cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs11122272 0.735 rs973252 chr1:231520802 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg25019033 chr10:957182 NA -0.54 -6.88 -0.35 3.03e-11 Eosinophil percentage of granulocytes; LUSC cis rs9326248 0.581 rs7120963 chr11:116830261 C/T cg26566898 chr11:117069891 TAGLN -0.34 -6.46 -0.33 3.78e-10 Blood protein levels; LUSC cis rs7712401 0.560 rs13168225 chr5:122347264 C/T cg19077854 chr5:122220652 SNX24 -0.38 -7.89 -0.4 4.33e-14 Mean platelet volume; LUSC cis rs6577655 0.517 rs9693237 chr8:135578218 G/A cg17885191 chr8:135476712 NA 0.58 7.49 0.38 6.04e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs950169 0.922 rs6603022 chr15:84830170 T/C cg17507749 chr15:85114479 UBE2QP1 -0.67 -8.67 -0.43 1.96e-16 Schizophrenia; LUSC trans rs6011368 0.585 rs13043326 chr20:62914092 C/A cg13869341 chr1:15865 WASH5P 0.4 6.13 0.32 2.52e-9 Clozapine-induced cytotoxicity; LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg16405210 chr4:1374714 KIAA1530 0.7 10.97 0.51 4.14e-24 Obesity-related traits; LUSC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg00944433 chr1:107599041 PRMT6 0.38 6.88 0.35 2.97e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg07061783 chr6:25882402 NA -0.36 -5.64 -0.3 3.55e-8 Blood metabolite levels; LUSC cis rs4776059 1.000 rs4776059 chr15:52886962 C/T cg22715398 chr15:52968154 KIAA1370 -0.71 -10.09 -0.48 4.56e-21 Schizophrenia; LUSC cis rs6754311 0.638 rs2322659 chr2:136555659 A/G cg07169764 chr2:136633963 MCM6 -0.71 -9.29 -0.45 2.02e-18 Mosquito bite size; LUSC cis rs4888262 0.545 rs4588013 chr16:74703388 C/T cg01733217 chr16:74700730 RFWD3 0.79 13.33 0.59 8.25e-33 Testicular germ cell tumor; LUSC cis rs17270561 0.609 rs7769908 chr6:25760539 G/A cg16482183 chr6:26056742 HIST1H1C 0.58 8.02 0.4 1.86e-14 Iron status biomarkers; LUSC cis rs2274273 0.773 rs10147765 chr14:55827826 G/A cg04306507 chr14:55594613 LGALS3 0.54 12.0 0.55 8.2e-28 Protein biomarker; LUSC cis rs11785400 0.793 rs34875149 chr8:143736131 G/A cg24634471 chr8:143751801 JRK 0.51 7.34 0.37 1.59e-12 Schizophrenia; LUSC cis rs4423214 0.610 rs3763856 chr11:71125345 G/A cg05163923 chr11:71159392 DHCR7 0.54 8.02 0.4 1.76e-14 Vitamin D levels; LUSC cis rs753778 0.629 rs2278447 chr8:142206905 G/C cg18755752 chr8:142205143 DENND3 -0.74 -13.12 -0.58 5.17e-32 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg23887609 chr12:130822674 PIWIL1 0.47 7.14 0.36 5.81e-12 Menopause (age at onset); LUSC trans rs8002861 0.905 rs9525869 chr13:44467210 A/G cg12856521 chr11:46389249 DGKZ 0.4 6.29 0.33 9.82e-10 Leprosy; LUSC cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg22875332 chr1:76189707 ACADM 0.82 14.07 0.61 1.28e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 3.01e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg14004847 chr7:1930337 MAD1L1 -0.51 -7.53 -0.38 4.89e-13 Bipolar disorder and schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17397028 chr4:91048584 FAM190A -0.43 -6.02 -0.31 4.68e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 5.81 0.3 1.49e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs61931739 0.517 rs10844738 chr12:34059503 T/A cg13010199 chr12:38710504 ALG10B 0.53 8.06 0.4 1.39e-14 Morning vs. evening chronotype; LUSC cis rs11583043 1.000 rs11583043 chr1:101466054 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.25 0.32 1.23e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9457247 0.529 rs6907666 chr6:167523395 A/G cg07741184 chr6:167504864 NA -0.46 -8.34 -0.42 2e-15 Crohn's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16101572 chr14:21566698 ZNF219;C14orf176 0.45 6.63 0.34 1.37e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg03538708 chr1:25844672 NA -0.36 -5.89 -0.31 9.44e-9 Erythrocyte sedimentation rate; LUSC cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg22676075 chr6:135203613 NA 0.6 9.57 0.46 2.49e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs10791097 0.967 rs4366492 chr11:130717256 T/C cg12179176 chr11:130786555 SNX19 0.76 12.67 0.57 2.65e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg16031515 chr1:205743344 RAB7L1 -0.27 -5.65 -0.3 3.42e-8 Menarche (age at onset); LUSC trans rs8073060 0.586 rs7213804 chr17:34010931 T/G cg19694781 chr19:47549865 TMEM160 -1.13 -17.91 -0.7 9.52e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs6714710 0.535 rs13033383 chr2:98339513 C/T cg26665480 chr2:98280029 ACTR1B 0.62 8.55 0.42 4.34e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg06238570 chr21:40685208 BRWD1 -0.56 -9.03 -0.44 1.37e-17 Menarche (age at onset); LUSC cis rs6964587 1.000 rs411 chr7:91557758 C/G cg17063962 chr7:91808500 NA -0.57 -8.75 -0.43 1.07e-16 Breast cancer; LUSC cis rs6736093 0.965 rs4264571 chr2:112674149 T/C cg12686935 chr2:112915763 FBLN7 -0.37 -5.83 -0.3 1.29e-8 Coronary artery disease; LUSC cis rs10207060 0.500 rs4380264 chr2:240699378 G/T cg20333904 chr2:240724165 NA -0.38 -6.33 -0.33 7.69e-10 Obesity-related traits; LUSC cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg21573476 chr21:45109991 RRP1B -0.39 -6.25 -0.32 1.29e-9 Mean corpuscular volume; LUSC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.57 -8.43 -0.42 1.06e-15 Alzheimer's disease; LUSC trans rs2727020 0.754 rs1851990 chr11:49413336 C/T cg03929089 chr4:120376271 NA -0.83 -12.09 -0.55 3.76e-28 Coronary artery disease; LUSC cis rs7192380 0.639 rs12448486 chr16:69802878 G/A cg00738113 chr16:70207722 CLEC18C 0.33 6.71 0.34 8.21e-11 Sjögren's syndrome; LUSC cis rs3106136 0.527 rs2664894 chr4:95153831 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.41 -0.42 1.2e-15 Capecitabine sensitivity; LUSC cis rs67696533 0.600 rs4911238 chr20:31122639 C/T cg13636640 chr20:31349939 DNMT3B 0.46 6.04 0.31 4.18e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg13628971 chr7:2884303 GNA12 0.49 6.76 0.35 6.35e-11 Height; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg22048132 chr17:60005312 INTS2 0.48 7.1 0.36 7.43e-12 Triglycerides; LUSC trans rs3942852 0.594 rs10769311 chr11:48094009 T/C cg03929089 chr4:120376271 NA -0.58 -7.46 -0.38 7.43e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs4423214 0.879 rs1792284 chr11:71134966 A/G cg05163923 chr11:71159392 DHCR7 0.68 8.61 0.43 2.94e-16 Vitamin D levels; LUSC cis rs2274273 0.870 rs13379169 chr14:55741287 C/T cg04306507 chr14:55594613 LGALS3 0.57 13.25 0.59 1.67e-32 Protein biomarker; LUSC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.32 -0.33 8.26e-10 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03001986 chr5:176433640 UIMC1 -0.42 -6.26 -0.32 1.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg20933634 chr6:27740509 NA 0.4 5.87 0.31 1.06e-8 Parkinson's disease; LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg05717871 chr11:638507 DRD4 -0.39 -6.36 -0.33 6.61e-10 Systemic lupus erythematosus; LUSC cis rs765787 0.530 rs11854690 chr15:45516016 C/T cg25801113 chr15:45476975 SHF 0.34 7.0 0.36 1.37e-11 Uric acid levels; LUSC cis rs5769707 0.681 rs135879 chr22:50018651 C/T cg05373962 chr22:49881684 NA -0.39 -8.64 -0.43 2.4e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg17252645 chr8:143867129 LY6D 0.38 6.58 0.34 1.8e-10 Urinary tract infection frequency; LUSC cis rs472402 0.507 rs8192139 chr5:6636973 C/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.39 -5.88 -0.31 9.78e-9 Response to amphetamines; LUSC trans rs6920965 0.583 rs9388456 chr6:126147197 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.25 -0.37 2.98e-12 High light scatter reticulocyte count; LUSC cis rs11039100 0.599 rs34123108 chr11:5834724 A/G cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.3 0.49 9.03e-22 Heart rate; LUSC cis rs8031584 0.918 rs3817498 chr15:31268781 T/C cg08704250 chr15:31115839 NA -0.47 -6.88 -0.35 3.01e-11 Huntington's disease progression; LUSC cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg08219700 chr8:58056026 NA 0.46 6.08 0.32 3.28e-9 Developmental language disorder (linguistic errors); LUSC trans rs11250097 0.549 rs11778177 chr8:11310362 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.13 -0.36 6.31e-12 Neuroticism; LUSC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg16339924 chr4:17578868 LAP3 0.57 8.83 0.44 5.87e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.9 -0.31 8.93e-9 Total body bone mineral density; LUSC cis rs9435732 1.000 rs9435732 chr1:17308158 C/T cg14981532 chr1:17215477 NA -0.38 -5.85 -0.3 1.16e-8 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in smokers;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg09655341 chr17:79618100 PDE6G -0.28 -6.58 -0.34 1.81e-10 Eye color traits; LUSC cis rs10754283 0.967 rs10737706 chr1:90112579 G/T cg21401794 chr1:90099060 LRRC8C 0.64 9.54 0.46 3.04e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg20503657 chr10:835505 NA 0.86 12.06 0.55 4.85e-28 Eosinophil percentage of granulocytes; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg16393715 chr7:1948819 MAD1L1 0.39 6.82 0.35 4.18e-11 Bipolar disorder and schizophrenia; LUSC cis rs9560113 1.000 rs9560110 chr13:112181233 C/T cg14154082 chr13:112174009 NA 0.38 7.88 0.4 4.53e-14 Menarche (age at onset); LUSC trans rs7726839 0.540 rs12520279 chr5:657291 T/C cg25482853 chr8:67687455 SGK3 1.09 15.45 0.65 5.28e-41 Obesity-related traits; LUSC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.15 0.32 2.2e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs61931739 0.500 rs7133447 chr12:34041901 A/G cg06521331 chr12:34319734 NA -0.49 -8.19 -0.41 5.73e-15 Morning vs. evening chronotype; LUSC cis rs782590 0.643 rs5012561 chr2:55742032 G/C cg03859395 chr2:55845619 SMEK2 -0.68 -10.08 -0.48 4.75e-21 Metabolic syndrome; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.07 0.32 3.56e-9 Lymphocyte counts; LUSC cis rs4704187 0.687 rs4621540 chr5:74371203 T/G cg03227963 chr5:74354835 NA 0.33 7.22 0.37 3.47e-12 Response to amphetamines; LUSC cis rs7247513 1.000 rs2042947 chr19:12693103 A/G cg01871581 chr19:12707946 ZNF490 -0.58 -9.08 -0.44 9.86e-18 Bipolar disorder; LUSC cis rs7106204 0.748 rs2403888 chr11:24208071 C/G ch.11.24196551F chr11:24239977 NA -1.12 -13.34 -0.59 8.11e-33 Response to Homoharringtonine (cytotoxicity); LUSC cis rs72634258 0.842 rs4908727 chr1:8163122 C/T cg26816564 chr1:7831052 VAMP3 0.42 5.77 0.3 1.78e-8 Inflammatory bowel disease; LUSC cis rs9515201 0.818 rs9521733 chr13:111034542 C/T cg05272587 chr13:111038400 COL4A2 0.4 6.8 0.35 4.93e-11 White matter hyperintensity burden; LUSC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg01475377 chr6:109611718 NA -0.38 -6.7 -0.34 9.02e-11 Reticulocyte fraction of red cells; LUSC cis rs16910800 0.689 rs7101737 chr11:23165031 C/T cg20040320 chr11:23191996 NA -0.59 -7.4 -0.38 1.1e-12 Cancer; LUSC trans rs10221833 0.602 rs429376 chr2:165634361 A/G cg26993132 chr16:89239499 CDH15 0.31 5.99 0.31 5.47e-9 Response to statin therapy; LUSC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg04398451 chr17:18023971 MYO15A 0.55 9.28 0.45 2.23e-18 Total body bone mineral density; LUSC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg04518342 chr5:131593106 PDLIM4 0.33 5.97 0.31 6.02e-9 Blood metabolite levels; LUSC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg18876405 chr7:65276391 NA -0.58 -9.41 -0.46 8.44e-19 Aortic root size; LUSC cis rs10791323 0.569 rs2156680 chr11:133742292 T/G cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg13628971 chr7:2884303 GNA12 0.45 6.29 0.33 9.81e-10 Height; LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.18 0.52 7.37e-25 Menopause (age at onset); LUSC trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.51 -0.38 5.47e-13 Monocyte count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06463759 chr7:128502823 ATP6V1F -0.37 -6.15 -0.32 2.25e-9 Electrocardiographic conduction measures; LUSC cis rs9402673 0.517 rs978036 chr6:135342903 C/T cg22676075 chr6:135203613 NA 0.47 7.37 0.37 1.32e-12 Reticulocyte count;High light scatter reticulocyte count; LUSC cis rs2455601 0.786 rs3763913 chr11:8951230 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -7.36 -0.37 1.47e-12 Schizophrenia; LUSC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.63 6.1 0.32 2.87e-9 Cerebrospinal P-tau181p levels; LUSC cis rs12421382 0.659 rs11604254 chr11:109392413 G/A cg16359550 chr11:109292809 C11orf87 0.37 6.33 0.33 7.74e-10 Schizophrenia; LUSC trans rs61931739 0.534 rs11053073 chr12:34202412 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.62 0.43 2.75e-16 Morning vs. evening chronotype; LUSC cis rs2386661 0.712 rs11259544 chr10:5646708 T/C cg12223502 chr10:5658492 NA -0.37 -5.77 -0.3 1.81e-8 Breast cancer; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.95 0.31 6.69e-9 Lung cancer; LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg02475777 chr4:1388615 CRIPAK -0.58 -8.59 -0.43 3.33e-16 Obesity-related traits; LUSC cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.07 0.4 1.32e-14 Axial length; LUSC trans rs8072100 0.656 rs2610367 chr17:45569815 A/G cg03886242 chr7:26192032 NFE2L3 -0.42 -6.67 -0.34 1.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11792861 0.926 rs72607174 chr9:111899132 A/T cg05043794 chr9:111880884 C9orf5 -0.36 -7.78 -0.39 9.33e-14 Menarche (age at onset); LUSC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg13206674 chr6:150067644 NUP43 0.55 8.56 0.42 4.22e-16 Lung cancer; LUSC cis rs73198271 0.740 rs10112989 chr8:8647334 A/C cg01851573 chr8:8652454 MFHAS1 0.53 8.45 0.42 8.97e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs35883536 0.588 rs10465764 chr1:101105030 A/G cg06223162 chr1:101003688 GPR88 0.35 6.3 0.33 9.4e-10 Monocyte count; LUSC cis rs13385 0.769 rs7722986 chr5:139617386 G/A cg26211634 chr5:139558579 C5orf32 0.44 6.86 0.35 3.4e-11 Atrial fibrillation; LUSC cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg11244672 chr19:19639970 YJEFN3 -0.58 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg02269571 chr22:50332266 NA -0.59 -9.03 -0.44 1.36e-17 Schizophrenia; LUSC cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg02527881 chr3:46936655 PTH1R 0.4 7.0 0.36 1.41e-11 Colorectal cancer; LUSC cis rs62400317 0.762 rs72865924 chr6:44878943 G/A cg20913747 chr6:44695427 NA -0.48 -7.44 -0.38 8.79e-13 Total body bone mineral density; LUSC cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg13010199 chr12:38710504 ALG10B 0.65 10.06 0.48 5.87e-21 Bladder cancer; LUSC cis rs7954584 0.616 rs10743185 chr12:122356435 G/A cg22618164 chr12:122356400 WDR66 0.55 7.77 0.39 9.9e-14 Mean corpuscular volume; LUSC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg15744005 chr10:104629667 AS3MT 0.3 6.13 0.32 2.48e-9 Waist circumference;Hip circumference; LUSC trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg03929089 chr4:120376271 NA -0.55 -6.77 -0.35 5.8e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs3733585 0.683 rs6449140 chr4:9936437 G/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.27 -0.45 2.31e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs61931739 0.817 rs2203086 chr12:34232590 T/C cg13010199 chr12:38710504 ALG10B 0.38 6.09 0.32 3.17e-9 Morning vs. evening chronotype; LUSC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg21251018 chr6:28226885 NKAPL 0.31 5.99 0.31 5.55e-9 Cardiac Troponin-T levels; LUSC cis rs1729951 0.575 rs1682357 chr3:136692009 G/A cg21827317 chr3:136751795 NA 0.39 6.96 0.36 1.84e-11 Neuroticism; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.43 6.87 0.35 3.19e-11 Menopause (age at onset); LUSC cis rs9457247 0.967 rs382009 chr6:167403121 G/C cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs16937 0.711 rs10751431 chr1:205128059 C/T cg00857998 chr1:205179979 DSTYK 0.47 6.7 0.34 8.64e-11 Schizophrenia; LUSC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.66 -0.3 3.2e-8 Life satisfaction; LUSC cis rs208520 0.690 rs12202805 chr6:66703903 A/G cg07460842 chr6:66804631 NA -1.07 -17.03 -0.68 2.93e-47 Exhaled nitric oxide output; LUSC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg07701084 chr6:150067640 NUP43 0.57 8.66 0.43 1.98e-16 Lung cancer; LUSC cis rs244731 1.000 rs244730 chr5:176539212 A/G cg17509989 chr5:176798049 RGS14 -0.61 -8.79 -0.43 8e-17 Urate levels in lean individuals; LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg18099408 chr3:52552593 STAB1 -0.41 -7.14 -0.36 5.86e-12 Bipolar disorder; LUSC cis rs7523273 0.606 rs2796266 chr1:207922945 C/T cg22525895 chr1:207977042 MIR29B2 -0.41 -6.71 -0.34 8.38e-11 Schizophrenia; LUSC cis rs17270561 0.609 rs4712968 chr6:25760344 T/C cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.51 -0.42 6.1e-16 Obesity-related traits; LUSC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg12311346 chr5:56204834 C5orf35 0.61 9.37 0.46 1.09e-18 Coronary artery disease; LUSC cis rs7945718 0.811 rs7104832 chr11:12786489 A/G cg25843174 chr11:12811716 TEAD1 0.33 7.34 0.37 1.64e-12 Educational attainment (years of education); LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg07677032 chr17:61819896 STRADA 0.52 8.7 0.43 1.55e-16 Prudent dietary pattern; LUSC cis rs2760061 0.599 rs849903 chr1:228137659 T/C cg01973587 chr1:228161476 NA 0.47 8.35 0.42 1.89e-15 Diastolic blood pressure; LUSC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg27124370 chr19:33622961 WDR88 0.56 7.74 0.39 1.17e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.51 -8.39 -0.42 1.41e-15 Lymphocyte counts; LUSC cis rs7916697 0.578 rs1900002 chr10:70004552 G/C cg06988349 chr10:69991859 ATOH7 0.33 5.8 0.3 1.56e-8 Optic disc area; LUSC cis rs10761482 0.859 rs1599166 chr10:62163729 G/A cg18175470 chr10:62150864 ANK3 -0.58 -8.72 -0.43 1.34e-16 Schizophrenia; LUSC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg09877947 chr5:131593287 PDLIM4 -0.37 -5.87 -0.31 1.03e-8 Breast cancer;Mosquito bite size; LUSC cis rs10465746 0.780 rs11163867 chr1:84384847 C/T cg10977910 chr1:84465055 TTLL7 0.42 6.1 0.32 3.01e-9 Obesity-related traits; LUSC trans rs11039798 0.920 rs11040013 chr11:48782862 G/A cg15704280 chr7:45808275 SEPT13 0.75 7.06 0.36 9.46e-12 Axial length; LUSC cis rs2179367 0.600 rs1001305 chr6:149757944 G/A cg07828024 chr6:149772892 ZC3H12D -0.35 -5.86 -0.31 1.12e-8 Dupuytren's disease; LUSC cis rs6545883 0.894 rs778144 chr2:61583128 A/C cg15711740 chr2:61764176 XPO1 0.42 6.59 0.34 1.69e-10 Tuberculosis; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg14004847 chr7:1930337 MAD1L1 -0.52 -8.03 -0.4 1.71e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs7173743 0.756 rs8032842 chr15:79125849 G/A cg00540400 chr15:79124168 NA 0.37 6.44 0.33 4.18e-10 Coronary artery disease; LUSC cis rs4555082 0.874 rs11625098 chr14:105756891 A/G cg13114125 chr14:105738426 BRF1 -0.96 -15.52 -0.65 2.85e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg17507749 chr15:85114479 UBE2QP1 0.5 5.88 0.31 9.94e-9 Schizophrenia; LUSC cis rs1775715 0.737 rs2799000 chr10:32124894 C/T cg26784012 chr10:32216390 ARHGAP12 0.44 7.39 0.37 1.21e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg05623727 chr3:50126028 RBM5 0.32 5.96 0.31 6.24e-9 Intelligence (multi-trait analysis); LUSC cis rs41271473 0.898 rs12028277 chr1:228829657 A/G cg10167378 chr1:228756711 NA 0.64 8.08 0.4 1.22e-14 Chronic lymphocytic leukemia; LUSC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg03709012 chr19:19516395 GATAD2A -0.83 -13.78 -0.6 1.6e-34 Tonsillectomy; LUSC trans rs3960554 0.867 rs76408713 chr7:75829540 G/A cg19862616 chr7:65841803 NCRNA00174 0.89 9.7 0.47 8.88e-20 Eotaxin levels; LUSC trans rs9291683 0.588 rs35866697 chr4:10018604 C/A cg26043149 chr18:55253948 FECH 0.49 7.47 0.38 7.27e-13 Bone mineral density; LUSC cis rs2235649 0.592 rs8051883 chr16:1958978 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.49 -6.16 -0.32 2.09e-9 Blood metabolite levels; LUSC cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg11941060 chr3:133502564 NA -0.46 -6.78 -0.35 5.4e-11 Iron status biomarkers; LUSC cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs734999 0.549 rs6670198 chr1:2520527 T/C cg18932078 chr1:2524107 MMEL1 0.3 6.61 0.34 1.55e-10 Ulcerative colitis; LUSC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg09796270 chr17:17721594 SREBF1 0.39 6.85 0.35 3.47e-11 Total body bone mineral density; LUSC cis rs9039 1.000 rs67302637 chr16:9221100 C/T cg08831531 chr16:9218945 NA -0.65 -9.82 -0.47 3.59e-20 Menopause (age at onset); LUSC trans rs7829975 0.711 rs12682352 chr8:8646246 A/G cg21775007 chr8:11205619 TDH 0.48 7.08 0.36 8.29e-12 Mood instability; LUSC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg02269571 chr22:50332266 NA -0.51 -7.53 -0.38 4.88e-13 Schizophrenia; LUSC trans rs28647808 0.786 rs4962137 chr9:136256826 G/T cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs79390637 1 rs79390637 chr11:47456867 C/A cg20307385 chr11:47447363 PSMC3 0.66 9.74 0.47 6.62e-20 Intraocular pressure; LUSC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg17971929 chr21:40555470 PSMG1 -0.52 -7.67 -0.39 1.85e-13 Menarche (age at onset); LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg24503407 chr1:205819492 PM20D1 0.98 20.81 0.75 2.81e-62 Menarche (age at onset); LUSC cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg10518543 chr12:38710700 ALG10B 0.41 5.76 0.3 1.86e-8 Morning vs. evening chronotype; LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg16325326 chr1:53192061 ZYG11B -0.9 -16.97 -0.68 4.92e-47 Monocyte count; LUSC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg03609598 chr5:56110824 MAP3K1 -0.39 -5.77 -0.3 1.81e-8 Initial pursuit acceleration; LUSC trans rs4332037 0.950 rs11771828 chr7:1941003 T/C cg11693508 chr17:37793320 STARD3 0.65 7.95 0.4 2.93e-14 Bipolar disorder; LUSC cis rs1185460 0.967 rs4454730 chr11:118937444 G/A cg01677386 chr11:118938358 VPS11 -0.48 -6.86 -0.35 3.37e-11 Coronary artery disease; LUSC cis rs977987 0.835 rs4888379 chr16:75340231 A/T cg04384234 chr16:75411784 CFDP1 -0.39 -6.4 -0.33 5.36e-10 Dupuytren's disease; LUSC cis rs10788264 0.716 rs7091348 chr10:124016160 C/T cg09507567 chr10:124027408 NA 0.51 8.49 0.42 6.65e-16 Total body bone mineral density; LUSC cis rs11190604 1.000 rs4919466 chr10:102241213 T/C cg07080220 chr10:102295463 HIF1AN 0.64 8.6 0.43 3.12e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg11644478 chr21:40555479 PSMG1 0.93 17.29 0.69 2.65e-48 Cognitive function; LUSC cis rs10779751 0.922 rs2295080 chr1:11322628 G/T cg08854313 chr1:11322531 MTOR 0.89 15.39 0.64 9.02e-41 Body mass index; LUSC cis rs4319547 0.695 rs11058034 chr12:122894936 G/T cg05707623 chr12:122985044 ZCCHC8 0.7 8.42 0.42 1.14e-15 Body mass index; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg02475777 chr4:1388615 CRIPAK 0.44 6.56 0.34 2.1e-10 Obesity-related traits; LUSC cis rs6964587 0.967 rs41371748 chr7:91708219 A/G cg17063962 chr7:91808500 NA 0.51 7.81 0.39 7.3e-14 Breast cancer; LUSC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.86e-14 Melanoma; LUSC cis rs17401966 0.931 rs1555849 chr1:10400602 G/T cg19773385 chr1:10388646 KIF1B 0.57 10.09 0.48 4.41e-21 Hepatocellular carcinoma; LUSC cis rs3849570 0.925 rs6799080 chr3:81905591 G/A cg07356753 chr3:81810745 GBE1 -0.68 -11.34 -0.53 2.02e-25 Waist circumference;Body mass index; LUSC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg21782813 chr7:2030301 MAD1L1 -0.46 -7.95 -0.4 2.9e-14 Bipolar disorder and schizophrenia; LUSC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg01368799 chr11:117014884 PAFAH1B2 0.56 8.46 0.42 8.5e-16 Blood protein levels; LUSC cis rs679087 1.000 rs439639 chr12:29917641 A/C cg14258853 chr12:29935411 TMTC1 -0.98 -16.17 -0.66 7.67e-44 Schizophrenia; LUSC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg12310025 chr6:25882481 NA -0.53 -9.71 -0.47 8.83e-20 Blood metabolite levels; LUSC cis rs9790314 0.846 rs9834659 chr3:160980947 A/C cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 4.11e-20 Morning vs. evening chronotype; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg06600287 chr1:53387719 ECHDC2 -0.29 -6.26 -0.32 1.17e-9 Monocyte count; LUSC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.8 -0.39 8.05e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs17253792 0.822 rs10142497 chr14:56047948 C/T cg01858014 chr14:56050164 KTN1 0.89 7.26 0.37 2.75e-12 Putamen volume; LUSC cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg23711669 chr6:146136114 FBXO30 0.72 12.88 0.58 4.13e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.63e-9 Monocyte count; LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg11494091 chr17:61959527 GH2 0.64 13.65 0.6 5.1e-34 Prudent dietary pattern; LUSC cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.89 0.35 2.84e-11 Rheumatoid arthritis; LUSC cis rs7000551 0.715 rs1879793 chr8:22313986 G/A cg12081754 chr8:22256438 SLC39A14 0.48 7.33 0.37 1.72e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs668210 0.793 rs622779 chr11:65744247 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.56 -7.17 -0.37 4.83e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs7511006 0.893 rs2038049 chr22:50654888 G/C cg07895657 chr22:50616420 PANX2 -0.37 -6.34 -0.33 7.63e-10 Obesity-related traits; LUSC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg19318889 chr4:1322082 MAEA 0.52 8.86 0.44 5.02e-17 Longevity; LUSC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg00745463 chr17:30367425 LRRC37B -0.87 -10.22 -0.49 1.66e-21 Hip circumference adjusted for BMI; LUSC cis rs3736594 0.959 rs6547796 chr2:27975394 T/C cg27432699 chr2:27873401 GPN1 -0.64 -9.13 -0.45 6.53e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2463822 0.583 rs72919462 chr11:62035663 G/A cg06239285 chr11:62104954 ASRGL1 -0.59 -5.99 -0.31 5.44e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs701145 0.585 rs1527800 chr3:153875075 A/G cg17054900 chr3:154042577 DHX36 0.71 6.94 0.36 1.98e-11 Coronary artery disease; LUSC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg16680214 chr1:154839983 KCNN3 -0.54 -10.26 -0.49 1.2e-21 Prostate cancer; LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.71 12.0 0.55 7.98e-28 Prudent dietary pattern; LUSC cis rs4595586 0.545 rs12813151 chr12:39363405 C/G cg13010199 chr12:38710504 ALG10B -0.42 -6.15 -0.32 2.25e-9 Morning vs. evening chronotype; LUSC trans rs9831754 1.000 rs9855903 chr3:78347988 C/A cg06695833 chr19:18220682 MAST3 0.48 6.03 0.31 4.23e-9 Calcium levels; LUSC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg12463550 chr7:65579703 CRCP -0.51 -7.45 -0.38 8.18e-13 Aortic root size; LUSC cis rs11122272 0.735 rs2572252 chr1:231513653 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs9393777 0.588 rs6933213 chr6:26493909 T/C cg12826209 chr6:26865740 GUSBL1 0.68 7.82 0.39 7.17e-14 Intelligence (multi-trait analysis); LUSC cis rs6542838 0.641 rs4499468 chr2:99475204 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.14 -0.32 2.38e-9 Fear of minor pain; LUSC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.86e-14 Melanoma; LUSC cis rs1878931 0.858 rs3760083 chr16:3450052 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.81 -13.67 -0.6 4.37e-34 Body mass index (adult); LUSC cis rs12928939 1.000 rs12928939 chr16:71800045 G/A cg03805757 chr16:71968109 PKD1L3 -0.43 -6.15 -0.32 2.16e-9 Post bronchodilator FEV1; LUSC trans rs8072100 0.967 rs4794001 chr17:45720849 T/C cg03886242 chr7:26192032 NFE2L3 -0.38 -6.41 -0.33 5e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7824557 0.564 rs2572389 chr8:11236392 T/C cg27411982 chr8:10470053 RP1L1 -0.37 -5.9 -0.31 8.72e-9 Retinal vascular caliber; LUSC cis rs9420 0.961 rs7949841 chr11:57524700 G/C cg23127183 chr11:57508653 C11orf31 -0.57 -8.81 -0.43 6.86e-17 Schizophrenia; LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13012494 chr21:47604986 C21orf56 0.46 6.81 0.35 4.68e-11 Testicular germ cell tumor; LUSC cis rs11785400 0.928 rs750529 chr8:143744877 G/C cg10596483 chr8:143751796 JRK 0.61 9.39 0.46 9.87e-19 Schizophrenia; LUSC cis rs10761482 0.954 rs12261675 chr10:62065257 C/A cg18175470 chr10:62150864 ANK3 -0.45 -6.26 -0.32 1.2e-9 Schizophrenia; LUSC cis rs2235649 0.624 rs2076427 chr16:1817754 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 0.49 6.26 0.32 1.18e-9 Blood metabolite levels; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg21782813 chr7:2030301 MAD1L1 0.37 6.03 0.31 4.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs1577917 0.958 rs2225754 chr6:86449698 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.93 -0.44 2.88e-17 Response to antipsychotic treatment; LUSC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg07959070 chr22:50026188 C22orf34 -0.34 -6.88 -0.35 3.05e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC trans rs6502050 0.723 rs11657069 chr17:80083809 C/T cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs41271473 0.526 rs12353961 chr1:228738252 G/C cg10167378 chr1:228756711 NA 0.75 9.63 0.47 1.54e-19 Chronic lymphocytic leukemia; LUSC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg11742103 chr11:62369870 EML3;MTA2 0.55 8.99 0.44 1.9e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6469656 1.000 rs6988841 chr8:117730893 A/G cg24004040 chr8:117650383 NA -0.42 -6.22 -0.32 1.48e-9 Colorectal cancer; LUSC cis rs6840360 0.571 rs1978955 chr4:152509509 G/A cg22705602 chr4:152727874 NA -0.32 -6.54 -0.34 2.28e-10 Intelligence (multi-trait analysis); LUSC cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg00277334 chr10:82204260 NA -0.95 -20.11 -0.74 1.7e-59 Post bronchodilator FEV1; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02723399 chr22:19420170 HIRA;MRPL40 0.45 6.19 0.32 1.73e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg16482183 chr6:26056742 HIST1H1C 0.47 6.9 0.35 2.62e-11 Height; LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg21724239 chr8:58056113 NA 0.8 8.59 0.43 3.29e-16 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs806215 1.000 rs327511 chr7:127257261 G/T cg25922125 chr7:127225783 GCC1 0.49 6.33 0.33 7.92e-10 Type 2 diabetes; LUSC cis rs561341 0.739 rs6505267 chr17:30225950 A/C cg13647721 chr17:30228624 UTP6 0.66 7.73 0.39 1.26e-13 Hip circumference adjusted for BMI; LUSC cis rs7208859 0.623 rs11657777 chr17:29091785 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs7647973 0.710 rs6446284 chr3:49616997 A/G cg21659725 chr3:3221576 CRBN -0.71 -7.82 -0.39 7.08e-14 Menarche (age at onset); LUSC trans rs66887589 0.616 rs6822808 chr4:120217365 C/A cg25214090 chr10:38739885 LOC399744 0.39 6.04 0.31 4.14e-9 Diastolic blood pressure; LUSC cis rs9807841 0.592 rs6511707 chr19:10767790 C/T cg17710535 chr19:10819994 QTRT1 0.41 6.85 0.35 3.48e-11 Inflammatory skin disease; LUSC cis rs11958404 0.932 rs72816543 chr5:157416464 A/G cg05962755 chr5:157440814 NA 0.54 6.49 0.33 3.12e-10 IgG glycosylation; LUSC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg18876405 chr7:65276391 NA -0.54 -8.61 -0.43 2.97e-16 Aortic root size; LUSC cis rs7223966 1.000 rs7223966 chr17:61893398 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.84 0.35 3.88e-11 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs7786808 0.615 rs1563066 chr7:158194935 A/C cg02030672 chr11:45687055 CHST1 0.55 8.95 0.44 2.6e-17 Obesity-related traits; LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg06145435 chr7:1022769 CYP2W1 0.3 5.98 0.31 5.83e-9 Longevity;Endometriosis; LUSC cis rs2742234 0.910 rs2505505 chr10:43648221 G/T cg15436174 chr10:43711423 RASGEF1A -0.37 -6.8 -0.35 4.71e-11 Hirschsprung disease; LUSC cis rs6582630 0.621 rs10880656 chr12:38571220 A/C cg13010199 chr12:38710504 ALG10B -0.41 -6.07 -0.32 3.49e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs4148689 0.951 rs1820871 chr7:117189272 G/A cg10450175 chr16:88689712 ZC3H18 0.46 5.99 0.31 5.37e-9 Gout; LUSC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg00933542 chr6:150070202 PCMT1 0.29 6.0 0.31 5.2e-9 Lung cancer; LUSC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.52e-24 Aortic root size; LUSC cis rs1021993 0.597 rs79455200 chr1:209507767 G/A cg24446417 chr1:209558027 NA -0.35 -5.73 -0.3 2.25e-8 Gut microbiome composition (winter); LUSC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg21028142 chr17:79581711 NPLOC4 0.35 8.23 0.41 4.36e-15 Eye color traits; LUSC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg02807482 chr3:125708958 NA -0.48 -6.01 -0.31 4.79e-9 Blood pressure (smoking interaction); LUSC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg22166914 chr1:53195759 ZYG11B -0.7 -12.07 -0.55 4.3e-28 Monocyte count; LUSC cis rs10744422 1.000 rs7972447 chr12:123354545 C/G cg25930673 chr12:123319894 HIP1R -0.6 -5.93 -0.31 7.41e-9 Schizophrenia; LUSC cis rs2795502 1.000 rs2473119 chr10:43339038 A/T cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg23583168 chr7:148888333 NA 0.87 16.74 0.68 4.24e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs7824557 0.767 rs7003241 chr8:11169075 A/G cg15556689 chr8:8085844 FLJ10661 0.56 8.67 0.43 1.89e-16 Retinal vascular caliber; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12433217 chr1:25758112 TMEM57 -0.44 -6.89 -0.35 2.82e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4417855 0.665 rs6806459 chr3:187406785 C/T cg19198148 chr3:187451818 BCL6 0.55 9.95 0.48 1.39e-20 Granulocyte percentage of myeloid white cells; LUSC cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg02753203 chr1:228287806 NA -0.66 -11.29 -0.53 3.03e-25 Diastolic blood pressure; LUSC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg25456477 chr12:86230367 RASSF9 0.43 7.73 0.39 1.24e-13 Major depressive disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18470852 chr19:18682598 UBA52 0.8 6.29 0.33 9.99e-10 Cognitive performance; LUSC cis rs6499755 0.897 rs8046197 chr16:55346012 A/C cg02859129 chr16:55357253 IRX6 0.36 6.12 0.32 2.69e-9 Hypospadias; LUSC cis rs3008870 0.755 rs4655660 chr1:67402953 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.32 0.56 5.19e-29 Lymphocyte percentage of white cells; LUSC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg02788857 chr8:22132959 PIWIL2 0.4 7.77 0.39 9.75e-14 Hypertriglyceridemia; LUSC cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg03213289 chr20:61660250 NA 0.67 13.29 0.59 1.21e-32 Prostate cancer (SNP x SNP interaction); LUSC trans rs76248362 1.000 rs9510910 chr13:24437265 C/G cg00599770 chr7:27196825 HOXA7 0.48 5.99 0.31 5.56e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs151234 0.676 rs231970 chr16:28567004 A/G cg01378222 chr16:28622494 SULT1A1 -0.62 -8.36 -0.42 1.69e-15 Platelet distribution width; LUSC cis rs6580649 0.941 rs11609399 chr12:48501161 A/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.1 -0.32 2.9e-9 Lung cancer; LUSC cis rs1691799 0.867 rs1168348 chr12:66757168 G/A cg16791601 chr12:66731901 HELB -0.71 -12.37 -0.56 3.57e-29 White blood cell count (basophil); LUSC cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg23711669 chr6:146136114 FBXO30 0.9 16.87 0.68 1.33e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.94 0.55 1.29e-27 Personality dimensions; LUSC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg06008330 chr7:65541103 ASL 0.42 6.55 0.34 2.19e-10 Aortic root size; LUSC trans rs724744 0.742 rs1205938 chr6:22357296 A/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.06 -0.31 3.61e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC trans rs11039798 0.920 rs11500574 chr11:48713986 A/T cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC cis rs7618501 1.000 rs7618501 chr3:49772647 A/G cg13072238 chr3:49761600 GMPPB -0.39 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs4664304 0.714 rs66496937 chr2:160738509 A/G cg03641300 chr2:160917029 PLA2R1 -0.36 -5.76 -0.3 1.87e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg00129232 chr17:37814104 STARD3 -0.45 -6.49 -0.33 3.15e-10 Asthma; LUSC cis rs11229555 0.645 rs7931394 chr11:58212617 T/A cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9300255 0.679 rs10846507 chr12:123786492 G/T cg00376283 chr12:123451042 ABCB9 0.68 8.06 0.4 1.35e-14 Neutrophil percentage of white cells; LUSC cis rs10832963 1.000 rs7943121 chr11:18656062 G/C cg09201001 chr11:18656081 SPTY2D1 0.92 15.18 0.64 6.23e-40 Breast cancer; LUSC trans rs61931739 0.517 rs7313663 chr12:34417058 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.23 0.45 3.14e-18 Morning vs. evening chronotype; LUSC cis rs6076065 0.723 rs7988 chr20:23352685 C/A cg11657817 chr20:23433608 CST11 0.42 7.87 0.4 4.89e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs295140 0.565 rs295139 chr2:201159988 T/A cg23649088 chr2:200775458 C2orf69 0.38 5.75 0.3 1.98e-8 QT interval; LUSC cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 31.21 0.86 5.03e-101 Chronic sinus infection; LUSC cis rs3750965 0.919 rs12280942 chr11:68859683 A/G cg06818126 chr11:68850279 TPCN2 0.45 6.68 0.34 9.75e-11 Hair color; LUSC cis rs11645898 0.810 rs72787046 chr16:72079342 A/G cg14768367 chr16:72042858 DHODH -0.71 -7.76 -0.39 1.02e-13 Blood protein levels; LUSC cis rs72781680 1.000 rs72796326 chr2:24137047 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg02187348 chr16:89574699 SPG7 0.61 10.08 0.48 4.71e-21 Multiple myeloma (IgH translocation); LUSC cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg16006841 chr5:176797999 RGS14 -0.66 -9.69 -0.47 9.83e-20 Urate levels in lean individuals; LUSC cis rs117352156 0.943 rs7899136 chr10:29211322 A/T cg06394621 chr10:29236369 NA -0.48 -6.53 -0.34 2.47e-10 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs478304 0.651 rs4930312 chr11:65499719 G/A cg05805236 chr11:65401703 PCNXL3 -0.57 -9.25 -0.45 2.79e-18 Acne (severe); LUSC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.54e-21 Bipolar disorder; LUSC trans rs2587949 0.550 rs80182329 chr3:4226282 A/T cg15139668 chr4:4577005 NA -0.43 -6.32 -0.33 8.57e-10 Periodontitis (DPAL); LUSC cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg00132208 chr4:10120780 NA 0.36 5.72 0.3 2.36e-8 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2180341 0.513 rs12196828 chr6:127696864 C/T cg24812749 chr6:127587940 RNF146 0.63 9.34 0.46 1.37e-18 Breast cancer; LUSC cis rs10465746 0.967 rs12140068 chr1:84394286 A/C cg10977910 chr1:84465055 TTLL7 0.44 6.35 0.33 7e-10 Obesity-related traits; LUSC trans rs9291683 0.620 rs4383618 chr4:10125151 T/C cg26043149 chr18:55253948 FECH -0.54 -7.74 -0.39 1.19e-13 Bone mineral density; LUSC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs34779708 0.966 rs4934730 chr10:35415555 A/G cg04310649 chr10:35416472 CREM -0.43 -6.65 -0.34 1.23e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg22029157 chr1:209979665 IRF6 0.68 9.35 0.46 1.3e-18 Cleft lip with or without cleft palate; LUSC cis rs7107174 1.000 rs4128206 chr11:78015952 A/C cg02023728 chr11:77925099 USP35 0.44 6.73 0.35 7.44e-11 Testicular germ cell tumor; LUSC cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs4900538 0.855 rs12590993 chr14:102844064 A/G cg18135206 chr14:102964638 TECPR2 -1.01 -20.19 -0.74 7.86e-60 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg24812749 chr6:127587940 RNF146 0.92 13.89 0.6 6.41e-35 Breast cancer; LUSC cis rs926938 0.527 rs11084 chr1:115537933 A/G cg01522456 chr1:115632236 TSPAN2 -0.41 -6.36 -0.33 6.75e-10 Autism; LUSC trans rs3812049 0.826 rs6860245 chr5:127367998 G/C cg16011800 chr17:1958478 HIC1 0.45 6.14 0.32 2.37e-9 Lymphocyte counts;Red cell distribution width; LUSC cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg00530320 chr1:46809349 NSUN4 0.55 8.47 0.42 7.65e-16 Menopause (age at onset); LUSC cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg17366294 chr4:99064904 C4orf37 0.5 8.81 0.43 6.78e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg03146154 chr1:46216737 IPP 0.52 7.77 0.39 9.58e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.64 -0.43 2.43e-16 Schizophrenia; LUSC cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg11266682 chr4:10021025 SLC2A9 0.58 10.45 0.5 2.55e-22 Bone mineral density; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.31 0.53 2.59e-25 Prudent dietary pattern; LUSC trans rs1927790 0.759 rs7982697 chr13:96988839 A/G cg03198741 chr6:1003969 LOC285768 -0.4 -5.99 -0.31 5.55e-9 Body mass index; LUSC cis rs751728 1.000 rs2296748 chr6:33745071 C/T cg25922239 chr6:33757077 LEMD2 0.55 8.38 0.42 1.53e-15 Crohn's disease; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25390199 chr17:18761479 PRPSAP2 0.39 6.12 0.32 2.58e-9 Mosquito bite size; LUSC cis rs9420 0.807 rs12807357 chr11:57656902 C/T cg02958346 chr11:57425731 CLP1 -0.44 -6.08 -0.32 3.28e-9 Schizophrenia; LUSC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg11168104 chr5:1857477 NA -0.32 -5.65 -0.3 3.35e-8 Cardiovascular disease risk factors; LUSC trans rs7615952 0.576 rs4646759 chr3:125822946 G/C cg07211511 chr3:129823064 LOC729375 -0.75 -9.67 -0.47 1.2e-19 Blood pressure (smoking interaction); LUSC cis rs7582720 1.000 rs72932561 chr2:203848402 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs3845702 0.736 rs6733426 chr2:180830958 A/G cg01881094 chr2:180872142 CWC22 -1.04 -12.47 -0.56 1.5e-29 Schizophrenia; LUSC cis rs72901758 0.768 rs1567237 chr17:76246294 A/G cg25512537 chr17:76250053 NA -0.48 -8.57 -0.42 4.02e-16 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs7826238 0.539 rs2945891 chr8:8155475 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.22 0.32 1.53e-9 Systolic blood pressure; LUSC cis rs4285028 0.948 rs13083557 chr3:121687613 G/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.59 -0.46 2.19e-19 Multiple sclerosis; LUSC cis rs9937943 0.615 rs35495670 chr16:74610422 T/C cg01733217 chr16:74700730 RFWD3 0.61 6.49 0.33 3.02e-10 Neutrophil percentage of white cells; LUSC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg24060327 chr5:131705240 SLC22A5 -0.38 -6.25 -0.32 1.27e-9 Blood metabolite levels; LUSC cis rs2294693 0.891 rs9381024 chr6:40984262 A/C cg14769373 chr6:40998127 UNC5CL 0.52 5.9 0.31 8.88e-9 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs9399135 1.000 rs1014021 chr6:135334600 C/T cg24558204 chr6:135376177 HBS1L -0.58 -8.93 -0.44 2.96e-17 Red blood cell count; LUSC cis rs78366141 0.649 rs10428273 chr4:89672738 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.96 7.68 0.39 1.82e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs12765878 1.000 rs3814220 chr10:105647300 A/G cg11005552 chr10:105648138 OBFC1 0.36 5.68 0.3 2.86e-8 Coronary artery disease; LUSC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.82 0.39 6.91e-14 Electroencephalogram traits; LUSC trans rs724744 0.742 rs1205932 chr6:22358391 T/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg00999904 chr2:3704751 ALLC -0.46 -7.12 -0.36 6.61e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs273573 0.816 rs604672 chr11:30853226 C/G cg14844989 chr11:31128820 NA 0.36 5.74 0.3 2.18e-8 Total body bone mineral density; LUSC cis rs9527 0.615 rs10883804 chr10:104706520 G/A cg08330031 chr10:104623503 C10orf32 0.31 5.64 0.3 3.54e-8 Arsenic metabolism; LUSC cis rs17001868 0.527 rs73167009 chr22:40734249 T/C cg07138101 chr22:40742427 ADSL 0.64 7.62 0.38 2.72e-13 Mammographic density (dense area); LUSC trans rs1941687 0.831 rs12958029 chr18:31388680 A/G cg27147174 chr7:100797783 AP1S1 -0.45 -6.56 -0.34 2.05e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9473147 0.516 rs2171089 chr6:47515811 A/G cg02130027 chr6:47444894 CD2AP 0.36 5.74 0.3 2.07e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs9527 0.545 rs35756290 chr10:104585572 G/A cg05855489 chr10:104503620 C10orf26 0.63 8.77 0.43 9.4e-17 Arsenic metabolism; LUSC cis rs12776158 0.901 rs79980322 chr10:71201715 C/T cg12610070 chr10:71211762 TSPAN15 -0.46 -6.68 -0.34 9.75e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.42 6.01 0.31 4.85e-9 Tonsillectomy; LUSC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg18827107 chr12:86230957 RASSF9 -0.5 -7.29 -0.37 2.3e-12 Major depressive disorder; LUSC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg25456477 chr12:86230367 RASSF9 0.33 5.82 0.3 1.39e-8 Major depressive disorder; LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg18964960 chr10:1102726 WDR37 -0.46 -6.22 -0.32 1.5e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.74e-12 Resting heart rate; LUSC cis rs1127311 0.875 rs9427102 chr1:154586957 A/G cg17218026 chr1:154582156 ADAR 0.55 9.75 0.47 6.48e-20 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2658782 0.654 rs2605620 chr11:93247646 C/T cg15737290 chr11:93063684 CCDC67 0.62 8.03 0.4 1.64e-14 Pulmonary function decline; LUSC cis rs72634258 0.503 rs34177663 chr1:7833228 A/G cg26816564 chr1:7831052 VAMP3 1.04 14.2 0.61 4.06e-36 Inflammatory bowel disease; LUSC cis rs3770081 1.000 rs2164879 chr2:86261579 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.8 -5.68 -0.3 2.96e-8 Facial emotion recognition (sad faces); LUSC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg05472934 chr7:22766657 IL6 0.5 7.76 0.39 1.03e-13 Lung cancer; LUSC trans rs6951245 0.748 rs79658522 chr7:1095877 A/G cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg26373071 chr5:1325741 CLPTM1L 0.43 8.11 0.41 9.51e-15 Lung cancer; LUSC cis rs1215050 0.791 rs7688942 chr4:98832048 T/C cg05340658 chr4:99064831 C4orf37 0.43 6.74 0.35 7.11e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9287719 0.601 rs12996735 chr2:10716716 C/A cg00105475 chr2:10696890 NA 0.35 5.92 0.31 8.12e-9 Prostate cancer; LUSC cis rs4964805 1.000 rs12228207 chr12:104196734 T/C cg02344784 chr12:104178138 NT5DC3 0.43 6.71 0.34 8.11e-11 Attention deficit hyperactivity disorder; LUSC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg22532475 chr10:104410764 TRIM8 -0.28 -5.85 -0.31 1.15e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9796 0.621 rs12324159 chr15:41462468 G/A cg18705301 chr15:41695430 NDUFAF1 -0.51 -8.81 -0.43 6.79e-17 Menopause (age at onset); LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 12.88 0.58 4.13e-31 Platelet count; LUSC cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg06454157 chr6:167490870 NA -0.24 -6.04 -0.31 4.19e-9 Crohn's disease; LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg17366294 chr4:99064904 C4orf37 0.6 10.77 0.51 2.0500000000000001e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs28655083 0.529 rs285026 chr16:77100089 G/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.37 5.87 0.31 1.06e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs9326248 0.581 rs7120515 chr11:116991926 A/G cg10130564 chr11:117069849 TAGLN 0.32 6.19 0.32 1.78e-9 Blood protein levels; LUSC cis rs5758511 0.680 rs5758651 chr22:42609148 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.88 -0.31 9.74e-9 Birth weight; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03112782 chr1:37979729 MEAF6 0.43 6.45 0.33 3.83e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs35000415 0.938 rs71581958 chr7:128665542 C/T cg19972273 chr7:128594194 NA 0.68 6.9 0.35 2.56e-11 Systemic lupus erythematosus; LUSC cis rs1691799 0.899 rs903587 chr12:66746061 C/A cg16791601 chr12:66731901 HELB -0.71 -12.52 -0.57 9.7e-30 White blood cell count (basophil); LUSC trans rs7829975 0.688 rs7826654 chr8:8379106 C/T cg21775007 chr8:11205619 TDH 0.45 6.63 0.34 1.34e-10 Mood instability; LUSC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg09359103 chr1:154839909 KCNN3 -0.7 -16.12 -0.66 1.23e-43 Prostate cancer; LUSC cis rs9815354 1.000 rs17063584 chr3:41861463 A/G cg03022575 chr3:42003672 ULK4 0.59 6.55 0.34 2.18e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs3820928 0.904 rs4129884 chr2:227820943 G/A cg11843606 chr2:227700838 RHBDD1 -0.52 -7.66 -0.39 2e-13 Pulmonary function; LUSC cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg16586182 chr3:47516702 SCAP -0.52 -7.99 -0.4 2.18e-14 Colorectal cancer; LUSC cis rs887829 0.570 rs6724485 chr2:234592816 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -6.16 -0.32 2.13e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs10435719 0.834 rs6985792 chr8:11795335 T/C cg14343924 chr8:8086146 FLJ10661 0.45 6.23 0.32 1.39e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg17691542 chr6:26056736 HIST1H1C 1.01 13.97 0.61 3.15e-35 Iron status biomarkers; LUSC cis rs61931739 0.890 rs11053018 chr12:34105962 T/G cg06521331 chr12:34319734 NA 0.37 6.2 0.32 1.7e-9 Morning vs. evening chronotype; LUSC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg05347473 chr6:146136440 FBXO30 0.56 9.49 0.46 4.63e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9326248 0.954 rs8521 chr11:117067699 C/T cg10130564 chr11:117069849 TAGLN 0.36 6.24 0.32 1.35e-9 Blood protein levels; LUSC cis rs8092503 1.000 rs3764516 chr18:52494374 A/C cg12377874 chr18:52495404 RAB27B -0.34 -6.18 -0.32 1.9e-9 Childhood body mass index; LUSC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg09165964 chr15:75287851 SCAMP5 0.51 7.42 0.38 9.85e-13 Breast cancer; LUSC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg02807482 chr3:125708958 NA -0.53 -7.08 -0.36 8.57e-12 Blood pressure (smoking interaction); LUSC cis rs6460942 0.908 rs3887296 chr7:12257966 A/G cg06484146 chr7:12443880 VWDE -0.59 -6.05 -0.31 3.93e-9 Coronary artery disease; LUSC cis rs10744422 1.000 rs897385 chr12:123341297 A/G cg25930673 chr12:123319894 HIP1R -0.72 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg00316803 chr15:76480434 C15orf27 -0.4 -6.77 -0.35 5.8e-11 Blood metabolite levels; LUSC cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.61 -0.6 7.34e-34 Chronic sinus infection; LUSC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg06850241 chr22:41845214 NA 0.34 6.22 0.32 1.46e-9 Vitiligo; LUSC cis rs6733011 0.506 rs11123755 chr2:99507948 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.94 -0.35 2.1e-11 Bipolar disorder; LUSC trans rs1945213 0.694 rs1384099 chr11:55866040 A/C cg15704280 chr7:45808275 SEPT13 0.74 8.4 0.42 1.26e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs7100689 0.646 rs1934692 chr10:82125734 C/A cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC trans rs7613875 0.521 rs4688754 chr3:50074641 G/T cg21659725 chr3:3221576 CRBN -0.53 -8.46 -0.42 8.33e-16 Body mass index; LUSC cis rs8060686 0.641 rs28508024 chr16:68126606 T/C cg27539214 chr16:67997921 SLC12A4 -0.55 -7.56 -0.38 3.86e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12421382 0.659 rs1371331 chr11:109382578 G/A cg27471124 chr11:109292789 C11orf87 0.41 7.22 0.37 3.52e-12 Schizophrenia; LUSC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg19592336 chr6:28129416 ZNF389 0.48 6.29 0.33 9.69e-10 Depression; LUSC cis rs9303401 0.659 rs7210700 chr17:56668186 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11644478 chr21:40555479 PSMG1 -0.84 -15.3 -0.64 2.06e-40 Cognitive function; LUSC cis rs59918340 0.764 rs4961339 chr8:142231504 A/G cg23750338 chr8:142222470 SLC45A4 0.58 11.27 0.52 3.44e-25 Immature fraction of reticulocytes; LUSC cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg08645402 chr16:4508243 NA 0.51 8.22 0.41 4.69e-15 Schizophrenia; LUSC cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg08564027 chr20:61660810 NA 0.91 17.38 0.69 1.19e-48 Prostate cancer (SNP x SNP interaction); LUSC trans rs10511400 0.541 rs2131174 chr3:119921317 C/T cg02809009 chr19:50354510 PTOV1 -0.73 -6.52 -0.34 2.64e-10 Economic and political preferences (feminism/equality); LUSC cis rs7474896 0.537 rs1779068 chr10:38250785 G/A cg25427524 chr10:38739819 LOC399744 0.43 5.66 0.3 3.19e-8 Obesity (extreme); LUSC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs9807989 0.507 rs4851572 chr2:103019031 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.17e-12 Asthma; LUSC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg08470875 chr2:26401718 FAM59B -0.66 -8.86 -0.44 4.75e-17 Gut microbiome composition (summer); LUSC cis rs1568889 0.838 rs11030185 chr11:28041904 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.91 0.58 3.18e-31 Bipolar disorder; LUSC cis rs858239 0.600 rs13438179 chr7:23143851 T/C cg23682824 chr7:23144976 KLHL7 0.38 5.66 0.3 3.28e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7681440 0.583 rs2736988 chr4:90776345 C/T cg06632027 chr4:90757378 SNCA -0.36 -5.76 -0.3 1.93e-8 Dementia with Lewy bodies; LUSC trans rs34421088 0.506 rs2409755 chr8:11169983 G/A cg08975724 chr8:8085496 FLJ10661 0.43 6.29 0.33 9.99e-10 Neuroticism; LUSC cis rs10782582 0.609 rs11584577 chr1:76242378 A/G cg03433033 chr1:76189801 ACADM -0.4 -5.86 -0.31 1.08e-8 Daytime sleep phenotypes; LUSC trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg15704280 chr7:45808275 SEPT13 -0.82 -10.34 -0.49 6.21e-22 Coronary artery disease; LUSC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.48 -8.54 -0.42 4.81e-16 Total body bone mineral density; LUSC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg06001716 chr17:41278141 BRCA1;NBR2 -0.36 -5.91 -0.31 8.47e-9 Menopause (age at onset); LUSC cis rs2835872 0.965 rs2835848 chr21:39011073 C/T cg20424643 chr21:39039972 KCNJ6 0.39 6.05 0.31 3.87e-9 Electroencephalographic traits in alcoholism; LUSC cis rs6835098 1.000 rs6835098 chr4:174089238 T/C cg08422745 chr4:174089978 GALNT7 -0.82 -13.53 -0.59 1.5e-33 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs7666738 0.546 rs10461174 chr4:98698293 G/A cg17366294 chr4:99064904 C4orf37 0.55 8.67 0.43 1.95e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs12044355 0.827 rs16854783 chr1:231827371 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.39 -5.75 -0.3 1.99e-8 Alzheimer's disease; LUSC cis rs5758511 0.773 rs10154700 chr22:42365073 G/T cg12850546 chr22:42539477 CYP2D7P1 -0.5 -6.14 -0.32 2.4e-9 Birth weight; LUSC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg13393036 chr8:95962371 TP53INP1 -0.45 -9.13 -0.45 6.92e-18 Type 2 diabetes; LUSC trans rs9291683 0.561 rs3733584 chr4:10036506 T/C cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.01e-12 Bone mineral density; LUSC cis rs6500395 0.963 rs12919278 chr16:48692537 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.45e-28 Intelligence (multi-trait analysis); LUSC cis rs2354432 0.607 rs58941651 chr1:146784919 T/C cg25205988 chr1:146714368 CHD1L -1.02 -9.56 -0.46 2.63e-19 Mitochondrial DNA levels; LUSC cis rs208520 0.739 rs1935894 chr6:66891434 A/G cg07460842 chr6:66804631 NA -1.05 -15.96 -0.66 5.02e-43 Exhaled nitric oxide output; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04226365 chr6:44355287 CDC5L 0.77 6.24 0.32 1.3e-9 Cognitive performance; LUSC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg24110177 chr3:50126178 RBM5 -0.61 -10.26 -0.49 1.15e-21 Body mass index; LUSC trans rs890100 0.612 rs62161882 chr2:56660263 T/A cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.76e-9 Gut microbiome composition (summer); LUSC cis rs9549367 0.713 rs3024745 chr13:113821598 A/G cg00898013 chr13:113819073 PROZ -0.65 -9.04 -0.44 1.28e-17 Platelet distribution width; LUSC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg06346307 chr22:19949965 COMT 0.35 7.32 0.37 1.88e-12 Blood metabolite levels; LUSC cis rs8017423 0.935 rs12880102 chr14:90793526 G/T cg14092571 chr14:90743983 NA 0.36 5.92 0.31 8.11e-9 Mortality in heart failure; LUSC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg00316803 chr15:76480434 C15orf27 -0.38 -6.58 -0.34 1.78e-10 Blood metabolite levels; LUSC cis rs6582630 0.533 rs11181379 chr12:38332381 C/T cg26384229 chr12:38710491 ALG10B 0.55 8.13 0.41 8.25e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs12928939 0.815 rs61753635 chr16:71660404 G/A cg08717414 chr16:71523259 ZNF19 -0.42 -5.9 -0.31 8.85e-9 Post bronchodilator FEV1; LUSC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11890956 chr21:40555474 PSMG1 -0.73 -11.23 -0.52 4.71e-25 Menarche (age at onset); LUSC cis rs10088262 0.527 rs3911939 chr8:124793744 T/G cg20713898 chr8:124780851 FAM91A1 -0.53 -7.09 -0.36 7.83e-12 Pancreatic cancer; LUSC cis rs7973719 0.868 rs12825629 chr12:7355583 T/C cg07052231 chr12:7363540 PEX5 0.54 9.42 0.46 7.85e-19 IgG glycosylation; LUSC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.37 0.53 1.49e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg15320075 chr8:145703422 NA 0.63 10.98 0.51 3.83e-24 Age at first birth; LUSC cis rs7582180 0.627 rs4149523 chr2:101007039 T/C cg08017756 chr2:100939284 LONRF2 -0.43 -7.99 -0.4 2.18e-14 Intelligence (multi-trait analysis); LUSC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg24503407 chr1:205819492 PM20D1 0.44 5.89 0.31 9.62e-9 Parkinson's disease; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg05855489 chr10:104503620 C10orf26 -0.61 -8.36 -0.42 1.76e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3749237 1.000 rs2291542 chr3:49751585 C/T cg03060546 chr3:49711283 APEH 0.52 7.28 0.37 2.48e-12 Resting heart rate; LUSC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs17818399 0.633 rs2242033 chr2:46842410 A/G cg02822958 chr2:46747628 ATP6V1E2 0.36 6.13 0.32 2.42e-9 Height; LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg23758822 chr17:41437982 NA 1.03 18.84 0.72 1.82e-54 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06598631 chr6:88300029 RARS2;ORC3L 0.47 6.55 0.34 2.11e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs929354 0.772 rs1182441 chr7:157026650 A/G cg05182265 chr7:156933206 UBE3C 0.59 9.67 0.47 1.14e-19 Body mass index; LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg25036284 chr2:26402008 FAM59B 0.77 10.94 0.51 5.08e-24 Gut microbiome composition (summer); LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -8.46 -0.42 8.49e-16 Lymphocyte counts; LUSC cis rs4700695 0.511 rs29443 chr5:65504927 G/A cg21114390 chr5:65439923 SFRS12 -0.51 -7.46 -0.38 7.57e-13 Facial morphology (factor 19); LUSC cis rs62400317 0.859 rs10948226 chr6:45299174 G/C cg20913747 chr6:44695427 NA -0.48 -7.77 -0.39 9.74e-14 Total body bone mineral density; LUSC trans rs17685 0.712 rs1639620 chr7:75704090 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.57e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg08975724 chr8:8085496 FLJ10661 -0.49 -7.14 -0.36 5.73e-12 Mood instability; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10019429 chr19:32836659 ZNF507 -0.42 -6.35 -0.33 7.19e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -7.32 -0.37 1.85e-12 Developmental language disorder (linguistic errors); LUSC cis rs7264396 0.635 rs6060675 chr20:34493614 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.85 -0.44 5.17e-17 Total cholesterol levels; LUSC cis rs17270561 0.609 rs9366629 chr6:25741216 G/A cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs2075671 0.903 rs11973874 chr7:100263272 T/C cg16850897 chr7:100343110 ZAN -0.52 -7.15 -0.36 5.63e-12 Other erythrocyte phenotypes; LUSC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg18351406 chr4:77819688 ANKRD56 0.59 8.57 0.42 3.94e-16 Emphysema distribution in smoking; LUSC cis rs668210 0.947 rs610497 chr11:65765551 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.58 7.95 0.4 2.81e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs7939886 0.920 rs11534518 chr11:55808146 C/T cg03929089 chr4:120376271 NA 0.74 6.28 0.32 1.07e-9 Myopia (pathological); LUSC cis rs2562152 0.786 rs216594 chr16:103009 A/T cg02949481 chr16:131562 MPG 0.51 6.2 0.32 1.66e-9 Glioblastoma; LUSC cis rs62400317 0.762 rs857601 chr6:44805214 G/T cg18551225 chr6:44695536 NA 0.43 7.0 0.36 1.44e-11 Total body bone mineral density; LUSC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg23172400 chr8:95962367 TP53INP1 -0.35 -6.63 -0.34 1.39e-10 Type 2 diabetes; LUSC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg22834771 chr12:69754056 YEATS4 -0.44 -6.24 -0.32 1.33e-9 Blood protein levels; LUSC cis rs3820928 0.692 rs2396434 chr2:227775223 G/T cg11843606 chr2:227700838 RHBDD1 -0.66 -10.66 -0.5 4.85e-23 Pulmonary function; LUSC cis rs1979679 0.541 rs4931085 chr12:28727510 C/T cg13890972 chr12:28721907 NA -0.41 -6.0 -0.31 5.13e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs6964587 1.000 rs13239875 chr7:91716104 G/A cg22709100 chr7:91322751 NA 0.4 5.9 0.31 8.7e-9 Breast cancer; LUSC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg09323728 chr8:95962352 TP53INP1 -0.3 -5.67 -0.3 3.1e-8 Type 2 diabetes; LUSC cis rs36093844 0.898 rs11234462 chr11:85596924 C/T cg16165120 chr11:85566439 CCDC83 -0.35 -5.72 -0.3 2.33e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs796364 0.755 rs6739563 chr2:201134216 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.64 7.21 0.37 3.77e-12 Schizophrenia; LUSC cis rs7954584 0.611 rs3887885 chr12:122336486 C/T cg10207240 chr12:122356781 WDR66 0.45 6.63 0.34 1.32e-10 Mean corpuscular volume; LUSC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg07701084 chr6:150067640 NUP43 0.53 7.78 0.39 8.86e-14 Lung cancer; LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03934478 chr11:495069 RNH1 0.88 9.99 0.48 9.94e-21 Body mass index; LUSC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg07701084 chr6:150067640 NUP43 0.5 7.44 0.38 8.36e-13 Lung cancer; LUSC cis rs7904368 0.754 rs7076779 chr10:16852667 C/T cg23933602 chr10:16859644 RSU1 0.62 7.71 0.39 1.49e-13 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.44e-8 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.913 rs28670284 chr22:50221973 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.48 6.69 0.34 9.37e-11 Schizophrenia; LUSC trans rs7849782 0.870 rs10819966 chr9:104418731 C/T cg22914338 chr19:14376960 NA 0.26 6.36 0.33 6.45e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9304742 0.854 rs11084211 chr19:53460861 C/T cg09503522 chr19:53445286 ZNF321 -0.36 -5.68 -0.3 2.89e-8 Psoriasis; LUSC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg16624210 chr5:671434 TPPP 0.5 6.34 0.33 7.37e-10 Obesity-related traits; LUSC trans rs1478897 0.575 rs12679960 chr8:11430990 C/T cg06636001 chr8:8085503 FLJ10661 0.55 7.87 0.4 4.83e-14 Systemic lupus erythematosus; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 10.17 0.49 2.43e-21 Lymphocyte counts; LUSC cis rs41271473 0.526 rs28593014 chr1:228743576 G/A cg16512390 chr1:228756714 NA 0.7 8.79 0.43 8.07e-17 Chronic lymphocytic leukemia; LUSC cis rs1577917 1.000 rs34622557 chr6:86630852 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.33 -0.33 8.06e-10 Response to antipsychotic treatment; LUSC cis rs5756813 0.754 rs762982 chr22:38144235 A/G cg06521852 chr22:38141419 TRIOBP -0.39 -6.04 -0.31 4.16e-9 Optic cup area;Vertical cup-disc ratio; LUSC cis rs7647973 0.577 rs6446247 chr3:49102001 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.65 9.33 0.45 1.54e-18 Menarche (age at onset); LUSC cis rs11785400 0.793 rs2280879 chr8:143722228 T/C cg24634471 chr8:143751801 JRK 0.51 7.18 0.37 4.68e-12 Schizophrenia; LUSC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg05785598 chr3:49045655 WDR6 0.32 5.73 0.3 2.21e-8 Parkinson's disease; LUSC cis rs367943 0.634 rs6594701 chr5:112685743 C/T cg12552261 chr5:112820674 MCC 0.39 6.41 0.33 4.93e-10 Type 2 diabetes; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg11564042 chr3:150479915 SIAH2 0.45 6.07 0.32 3.55e-9 Neuroticism; LUSC cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg18252515 chr7:66147081 NA -1.23 -13.78 -0.6 1.62e-34 Diabetic kidney disease; LUSC trans rs72674100 1.000 rs17026330 chr4:97969873 G/A cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.4 -6.4 -0.33 5.41e-10 Red blood cell count;Reticulocyte count; LUSC trans rs9747201 1.000 rs58472289 chr17:80111895 G/T cg07393940 chr7:158741817 NA -0.51 -8.15 -0.41 7.32e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs17401966 0.931 rs11587854 chr1:10447622 G/A cg19773385 chr1:10388646 KIF1B -0.58 -9.67 -0.47 1.13e-19 Hepatocellular carcinoma; LUSC cis rs2738048 0.545 rs2978950 chr8:6825284 C/G cg24860332 chr8:6827800 DEFA10P -0.4 -6.42 -0.33 4.67e-10 IgA nephropathy; LUSC cis rs611744 0.839 rs672552 chr8:109164223 A/G cg18478394 chr8:109455254 TTC35 0.42 6.32 0.33 8.15e-10 Dupuytren's disease; LUSC cis rs886126 0.684 rs10744769 chr12:111650780 G/T cg10833066 chr12:111807467 FAM109A 0.42 6.5 0.34 2.9e-10 Coronary heart disease; LUSC cis rs7584330 0.910 rs6737914 chr2:238393434 A/G cg14458575 chr2:238380390 NA 0.64 11.23 0.52 4.87e-25 Prostate cancer; LUSC trans rs1728785 1.000 rs1364109 chr16:68595505 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.22 0.41 4.57e-15 Ulcerative colitis; LUSC cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.39 -0.46 9.4e-19 Chronic sinus infection; LUSC cis rs7215564 0.818 rs1872431 chr17:78635200 T/C cg23238734 chr17:78661607 RPTOR 0.49 6.2 0.32 1.66e-9 Myopia (pathological); LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg10360139 chr7:1886902 MAD1L1 -0.44 -6.9 -0.35 2.61e-11 Bipolar disorder and schizophrenia; LUSC cis rs6582630 0.576 rs2387837 chr12:38403164 G/T cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.71e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.76 -0.39 1.07e-13 Blood metabolite levels; LUSC cis rs4343996 0.701 rs4255031 chr7:3378350 G/T cg21248987 chr7:3385318 SDK1 -0.37 -6.18 -0.32 1.88e-9 Motion sickness; LUSC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg06544989 chr22:39130855 UNC84B 0.33 5.74 0.3 2.18e-8 Menopause (age at onset); LUSC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg12963246 chr6:28129442 ZNF389 0.53 7.52 0.38 5.24e-13 Depression; LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12756686 chr19:29218302 NA 0.68 9.99 0.48 9.49e-21 Methadone dose in opioid dependence; LUSC cis rs7746199 0.736 rs72845070 chr6:27668300 A/C cg26958806 chr6:27640298 NA 0.81 6.24 0.32 1.35e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9914988 0.887 rs62066838 chr17:27184533 C/T cg09479241 chr17:27052676 TLCD1 -0.42 -5.76 -0.3 1.91e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg22535103 chr8:58192502 C8orf71 -0.8 -8.61 -0.43 2.94e-16 Developmental language disorder (linguistic errors); LUSC cis rs2933343 0.700 rs2624910 chr3:128650275 G/C cg11901034 chr3:128598214 ACAD9 -0.41 -6.5 -0.34 2.89e-10 IgG glycosylation; LUSC trans rs7618501 0.669 rs7634084 chr3:49949834 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.94 0.44 2.66e-17 Intelligence (multi-trait analysis); LUSC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg04166393 chr7:2884313 GNA12 0.43 5.89 0.31 9.37e-9 Height; LUSC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg17507749 chr15:85114479 UBE2QP1 0.67 8.55 0.42 4.4e-16 Schizophrenia; LUSC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg07636037 chr3:49044803 WDR6 0.98 15.22 0.64 4.11e-40 Parkinson's disease; LUSC cis rs727505 0.520 rs1454125 chr7:124862733 C/T cg23710748 chr7:124431027 NA -0.4 -6.87 -0.35 3.21e-11 Lewy body disease; LUSC cis rs7568458 0.684 rs60012532 chr2:85752474 A/C cg02493740 chr2:85810744 VAMP5 -0.5 -8.64 -0.43 2.37e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg24768116 chr2:27665128 KRTCAP3 0.3 5.82 0.3 1.36e-8 Total body bone mineral density; LUSC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg21862992 chr11:68658383 NA 0.51 8.18 0.41 6.18e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg07701084 chr6:150067640 NUP43 0.56 8.41 0.42 1.24e-15 Lung cancer; LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.48 -7.33 -0.37 1.8e-12 Systemic lupus erythematosus; LUSC cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC trans rs2797160 1.000 rs1935773 chr6:125996475 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.4 -0.33 5.18e-10 Endometrial cancer; LUSC cis rs2108225 0.967 rs7785790 chr7:107449896 C/T cg18560240 chr7:107437656 SLC26A3 0.39 6.0 0.31 5.05e-9 Ulcerative colitis; LUSC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg04998671 chr14:104000505 TRMT61A -0.4 -5.8 -0.3 1.51e-8 Reticulocyte count; LUSC cis rs12618769 0.597 rs72821908 chr2:99085359 A/G cg10123293 chr2:99228465 UNC50 0.45 7.58 0.38 3.5e-13 Bipolar disorder; LUSC cis rs7914558 0.966 rs12571568 chr10:104891396 C/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.05 -0.36 1.05e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg12927641 chr6:109611667 NA -0.36 -6.12 -0.32 2.69e-9 Reticulocyte fraction of red cells; LUSC cis rs11158026 0.603 rs17832269 chr14:55432091 C/T cg04306507 chr14:55594613 LGALS3 0.35 6.19 0.32 1.76e-9 Parkinson's disease; LUSC trans rs750134 0.901 rs77866012 chr12:109115755 G/A cg23338993 chr2:234600423 UGT1A10;UGT1A6;UGT1A9;UGT1A7;UGT1A8 0.48 6.05 0.31 3.96e-9 Low high density lipoprotein cholesterol levels; LUSC cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg04117972 chr1:227635322 NA 0.58 6.73 0.35 7.61e-11 Major depressive disorder; LUSC cis rs11711311 1.000 rs12695295 chr3:113474866 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.83 0.35 4e-11 IgG glycosylation; LUSC cis rs12908161 0.959 rs34784022 chr15:85231906 T/C cg12863693 chr15:85201151 NMB 0.42 8.65 0.43 2.14e-16 Schizophrenia; LUSC cis rs1018836 0.608 rs7843149 chr8:91474961 C/T cg16814680 chr8:91681699 NA -0.55 -8.02 -0.4 1.77e-14 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs10761482 0.861 rs7084499 chr10:62106882 A/G cg18175470 chr10:62150864 ANK3 -0.49 -6.95 -0.36 1.87e-11 Schizophrenia; LUSC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg00990874 chr7:1149470 C7orf50 -0.5 -6.33 -0.33 7.99e-10 Bronchopulmonary dysplasia; LUSC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.58 -0.42 3.61e-16 Bipolar disorder; LUSC cis rs7582180 0.629 rs13025184 chr2:100944842 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.57e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg08280861 chr8:58055591 NA 0.55 6.51 0.34 2.73e-10 Developmental language disorder (linguistic errors); LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg20295408 chr7:1910781 MAD1L1 -0.42 -6.07 -0.31 3.56e-9 Bipolar disorder and schizophrenia; LUSC cis rs1595825 0.838 rs6742343 chr2:198666752 C/T cg00982548 chr2:198649783 BOLL -0.6 -7.29 -0.37 2.2e-12 Ulcerative colitis; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg13395646 chr4:1353034 KIAA1530 0.58 8.88 0.44 4.26e-17 Obesity-related traits; LUSC cis rs1577917 0.958 rs10944147 chr6:86550786 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.72 -0.35 7.84e-11 Response to antipsychotic treatment; LUSC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg25554036 chr4:6271136 WFS1 0.58 11.76 0.54 5.83e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs62400317 0.518 rs1321080 chr6:45358323 G/T cg20913747 chr6:44695427 NA -0.43 -6.33 -0.33 7.72e-10 Total body bone mineral density; LUSC cis rs1775715 0.870 rs11008696 chr10:32218614 G/A cg18675610 chr10:32216311 ARHGAP12 0.28 6.13 0.32 2.53e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1577917 1.000 rs34622557 chr6:86630852 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.26 -0.41 3.4e-15 Response to antipsychotic treatment; LUSC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg05861140 chr6:150128134 PCMT1 -0.4 -6.3 -0.33 9.14e-10 Lung cancer; LUSC trans rs35110281 0.666 rs9977076 chr21:45085829 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 9.99 0.48 1.01e-20 Mean corpuscular volume; LUSC trans rs2834506 0.521 rs2300385 chr21:35900932 G/C cg00397714 chr2:192815005 TMEFF2 -0.33 -6.01 -0.31 4.9e-9 Cancer; LUSC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg15468180 chr1:107600409 PRMT6 0.4 6.31 0.33 8.99e-10 Facial morphology (factor 21, depth of nasal alae); LUSC trans rs12986445 0.625 rs3856394 chr2:26110143 A/G cg18530251 chr8:22409574 SORBS3 -0.42 -5.99 -0.31 5.38e-9 Multiple myeloma and monoclonal gammopathy;Multiple myeloma; LUSC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg01475377 chr6:109611718 NA 0.45 8.04 0.4 1.53e-14 Reticulocyte fraction of red cells; LUSC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg09034736 chr1:150693464 HORMAD1 -0.42 -5.66 -0.3 3.2e-8 Blood protein levels; LUSC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg08132940 chr7:1081526 C7orf50 -0.5 -5.9 -0.31 8.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg00129232 chr17:37814104 STARD3 -0.5 -7.49 -0.38 6.21e-13 Asthma; LUSC cis rs34779708 0.931 rs4934719 chr10:35376769 T/C cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg08859206 chr1:53392774 SCP2 -0.68 -13.02 -0.58 1.21e-31 Monocyte count; LUSC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg16743903 chr16:89593216 SPG7 -0.42 -6.32 -0.33 8.53e-10 Multiple myeloma (IgH translocation); LUSC cis rs9581857 0.547 rs9579086 chr13:28058537 T/A cg22138327 chr13:27999177 GTF3A 0.81 8.41 0.42 1.24e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs73206853 0.841 rs55972509 chr12:110992755 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.13 0.36 6.24e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg03354898 chr7:1950403 MAD1L1 -0.33 -6.43 -0.33 4.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs2439831 1.000 rs2444032 chr15:43755346 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.98 11.42 0.53 1.05e-25 Lung cancer in ever smokers; LUSC cis rs7084921 0.578 rs12765808 chr10:101872687 A/C cg02250046 chr10:101825185 CPN1 -0.35 -6.24 -0.32 1.34e-9 Bone mineral density; LUSC trans rs7939886 0.920 rs11231885 chr11:55804022 T/A cg03929089 chr4:120376271 NA 0.74 6.28 0.32 1.07e-9 Myopia (pathological); LUSC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg05347473 chr6:146136440 FBXO30 -0.53 -9.14 -0.45 6.36e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg00290607 chr11:67383545 NA 0.34 6.4 0.33 5.14e-10 Mean corpuscular volume; LUSC cis rs7824557 0.564 rs35009431 chr8:11232788 G/A cg27411982 chr8:10470053 RP1L1 -0.4 -6.19 -0.32 1.76e-9 Retinal vascular caliber; LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg14004847 chr7:1930337 MAD1L1 -0.49 -7.4 -0.38 1.12e-12 Bipolar disorder and schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21144673 chr22:42017783 PPPDE2;XRCC6 0.4 7.16 0.36 5.09e-12 Triglycerides; LUSC cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg22782873 chr19:19639568 YJEFN3 0.5 6.11 0.32 2.84e-9 Bipolar disorder; LUSC cis rs2439831 1.000 rs2439841 chr15:43734749 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.3 0.53 2.64e-25 Lung cancer in ever smokers; LUSC trans rs9329221 0.736 rs2001337 chr8:10251154 G/A cg08975724 chr8:8085496 FLJ10661 0.48 6.33 0.33 7.74e-10 Neuroticism; LUSC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg22963979 chr7:1858916 MAD1L1 -0.53 -8.04 -0.4 1.6e-14 Schizophrenia; LUSC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg19346786 chr7:2764209 NA -0.45 -7.69 -0.39 1.63e-13 Height; LUSC cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg08999081 chr20:33150536 PIGU 0.44 8.04 0.4 1.57e-14 Coronary artery disease; LUSC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg12564285 chr5:131593104 PDLIM4 0.35 6.33 0.33 7.98e-10 Blood metabolite levels; LUSC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.46 -0.33 3.63e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1003719 0.715 rs4261789 chr21:38503762 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.25 -0.49 1.28e-21 Eye color traits; LUSC cis rs12291225 0.883 rs1864658 chr11:14256444 C/T cg05501817 chr11:14380813 RRAS2 0.44 6.39 0.33 5.63e-10 Sense of smell; LUSC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg23719950 chr11:63933701 MACROD1 -0.61 -7.83 -0.39 6.47e-14 Mean platelet volume; LUSC cis rs9581857 0.725 rs117947621 chr13:28022267 T/C cg22138327 chr13:27999177 GTF3A 0.81 9.21 0.45 3.79e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs4974559 0.739 rs10029534 chr4:1322908 C/A cg02980000 chr4:1222292 CTBP1 1.04 9.6 0.46 2e-19 Systolic blood pressure; LUSC trans rs7843479 0.965 rs11135763 chr8:21813962 A/G cg10573190 chr2:85843190 USP39 -0.42 -6.05 -0.31 3.78e-9 Mean corpuscular volume; LUSC cis rs908922 0.627 rs1053588 chr1:152488063 C/T cg20991723 chr1:152506922 NA 0.5 9.16 0.45 5.28e-18 Hair morphology; LUSC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06481639 chr22:41940642 POLR3H -0.48 -5.84 -0.3 1.26e-8 Vitiligo; LUSC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg06238570 chr21:40685208 BRWD1 0.6 9.9 0.48 1.99e-20 Cognitive function; LUSC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg00166722 chr3:10149974 C3orf24 0.41 6.03 0.31 4.33e-9 Alzheimer's disease; LUSC cis rs4792901 0.918 rs12603189 chr17:41618677 C/G cg22562494 chr17:41607896 ETV4 0.28 5.72 0.3 2.37e-8 Dupuytren's disease; LUSC cis rs6733011 0.628 rs4850888 chr2:99456946 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -5.75 -0.3 1.98e-8 Bipolar disorder; LUSC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg04287289 chr16:89883240 FANCA 0.78 13.7 0.6 3.2e-34 Vitiligo; LUSC cis rs11098499 0.820 rs13122709 chr4:120555356 T/A cg24375607 chr4:120327624 NA 0.75 11.24 0.52 4.44e-25 Corneal astigmatism; LUSC cis rs11098499 0.566 rs17051356 chr4:120585308 C/T cg09307838 chr4:120376055 NA 0.71 9.77 0.47 5.19e-20 Corneal astigmatism; LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg04756594 chr16:24857601 SLC5A11 0.36 6.33 0.33 7.97e-10 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.39 -0.42 1.35e-15 Lung cancer; LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13126279 chr21:47581558 C21orf56 0.56 8.61 0.43 2.92e-16 Testicular germ cell tumor; LUSC cis rs55675132 1.000 rs55675132 chr1:115619634 C/T cg01522456 chr1:115632236 TSPAN2 -0.46 -5.66 -0.3 3.18e-8 Schizophrenia; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg23131131 chr22:24373011 LOC391322 -0.49 -6.72 -0.35 7.89e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg06363034 chr20:62225388 GMEB2 -0.46 -7.64 -0.39 2.3e-13 Glioblastoma; LUSC cis rs2835872 0.733 rs1709822 chr21:39035485 A/G cg20424643 chr21:39039972 KCNJ6 -0.44 -7.46 -0.38 7.63e-13 Electroencephalographic traits in alcoholism; LUSC cis rs2235649 0.833 rs7190337 chr16:1850469 A/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.44 -5.93 -0.31 7.67e-9 Blood metabolite levels; LUSC cis rs1982963 0.627 rs17124901 chr14:52488009 C/T cg10843707 chr14:52510701 NID2 0.46 6.51 0.34 2.73e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg20283391 chr11:68216788 NA -0.58 -8.13 -0.41 8.67e-15 Total body bone mineral density; LUSC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg02551604 chr5:131831745 NA -0.43 -6.93 -0.35 2.15e-11 Asthma (sex interaction); LUSC trans rs4714291 0.925 rs847755 chr6:40030378 T/C cg02267698 chr19:7991119 CTXN1 0.53 7.35 0.37 1.53e-12 Strep throat; LUSC cis rs10203711 1.000 rs2334022 chr2:239565612 T/C cg14580085 chr2:239553406 NA 0.4 6.9 0.35 2.57e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg24813613 chr7:1882135 MAD1L1 -0.43 -7.3 -0.37 2.18e-12 Bipolar disorder and schizophrenia; LUSC cis rs10911232 0.507 rs10752891 chr1:183023283 G/A ch.1.3577855R chr1:183094577 LAMC1 0.7 10.89 0.51 7.63e-24 Hypertriglyceridemia; LUSC cis rs6912958 0.712 rs6454640 chr6:88370352 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.51 7.31 0.37 1.94e-12 Monocyte percentage of white cells; LUSC cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg07817648 chr10:79422355 NA -0.54 -7.49 -0.38 6.11e-13 Bone mineral density; LUSC cis rs34779708 0.897 rs12830 chr10:35302705 C/T cg04310649 chr10:35416472 CREM -0.42 -6.25 -0.32 1.27e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg20476274 chr7:133979776 SLC35B4 0.8 13.9 0.61 5.79e-35 Mean platelet volume; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg24498587 chr11:123596947 ZNF202 -0.46 -6.1 -0.32 2.99e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg22903471 chr2:27725779 GCKR -0.41 -7.05 -0.36 1.05e-11 Total body bone mineral density; LUSC cis rs67072384 0.892 rs11235578 chr11:72452970 G/T cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9463078 0.616 rs2211393 chr6:44716366 A/C cg25276700 chr6:44698697 NA 0.31 6.45 0.33 3.88e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1729951 0.575 rs16844362 chr3:136704008 T/C cg12473912 chr3:136751656 NA 0.4 7.12 0.36 6.46e-12 Neuroticism; LUSC cis rs12200560 0.505 rs1334321 chr6:97079571 C/T cg06623918 chr6:96969491 KIAA0776 -0.48 -6.94 -0.36 2.02e-11 Coronary heart disease; LUSC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.29 0.33 9.77e-10 Melanoma; LUSC cis rs10892173 0.566 rs12364667 chr11:117675286 A/C cg21640587 chr11:117668038 DSCAML1 0.64 9.27 0.45 2.29e-18 Myopia; LUSC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg15448220 chr1:150897856 SETDB1 0.43 6.22 0.32 1.45e-9 Melanoma; LUSC cis rs1997103 1.000 rs6949222 chr7:55411264 C/T cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg15369054 chr17:80825471 TBCD -0.65 -11.08 -0.52 1.59e-24 Breast cancer; LUSC cis rs8040855 0.579 rs28521166 chr15:85728032 C/T cg04831495 chr15:85060580 GOLGA6L5 0.4 6.69 0.34 9.4e-11 Bulimia nervosa; LUSC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg11861562 chr11:117069780 TAGLN 0.45 8.1 0.41 1.02e-14 Blood protein levels; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg12432903 chr7:1882776 MAD1L1 -0.49 -8.13 -0.41 8.74e-15 Bipolar disorder and schizophrenia; LUSC cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg22307029 chr19:49891270 CCDC155 0.59 8.4 0.42 1.26e-15 Multiple sclerosis; LUSC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg25703541 chr22:24373054 LOC391322 0.9 14.74 0.63 3.01e-38 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1559088 0.901 rs7249983 chr19:33598851 C/A cg17764715 chr19:33622953 WDR88 0.6 8.25 0.41 3.8e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7980687 0.628 rs2851443 chr12:123694250 C/T cg05973401 chr12:123451056 ABCB9 0.52 7.13 0.36 6.38e-12 Height;Educational attainment;Head circumference (infant); LUSC cis rs4400599 0.618 rs1194602 chr1:154231943 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.77 -0.3 1.81e-8 Platelet distribution width; LUSC cis rs8072100 0.840 rs9893901 chr17:45506682 T/G cg25173405 chr17:45401733 C17orf57 -0.37 -5.73 -0.3 2.19e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs897984 0.542 rs35713203 chr16:31090407 G/C cg02466173 chr16:30829666 NA -0.48 -8.9 -0.44 3.6e-17 Dementia with Lewy bodies; LUSC cis rs3741151 1.000 rs60924672 chr11:73098724 A/C cg17517138 chr11:73019481 ARHGEF17 1.0 8.32 0.41 2.26e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg11764359 chr7:65958608 NA 0.52 6.85 0.35 3.5e-11 Aortic root size; LUSC trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs71403859 0.504 rs12926413 chr16:71972325 T/C cg03805757 chr16:71968109 PKD1L3 -0.59 -6.35 -0.33 7.15e-10 Post bronchodilator FEV1; LUSC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs9473147 0.571 rs9463335 chr6:47479136 G/A cg12968598 chr6:47444699 CD2AP 0.53 8.05 0.4 1.43e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs73198271 0.628 rs11777742 chr8:8589858 C/T cg01851573 chr8:8652454 MFHAS1 0.46 5.77 0.3 1.83e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.96e-13 Motion sickness; LUSC cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg13852791 chr20:30311386 BCL2L1 0.85 10.91 0.51 6.79e-24 Monocyte count; LUSC cis rs7705502 1.000 rs59755656 chr5:173378180 A/G cg18693985 chr5:173351052 CPEB4 -0.4 -6.22 -0.32 1.5e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9790314 1.000 rs336543 chr3:161061080 C/T cg04691961 chr3:161091175 C3orf57 0.35 6.04 0.31 4.03e-9 Morning vs. evening chronotype; LUSC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg07741184 chr6:167504864 NA 0.44 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs8044995 0.501 rs73613952 chr16:68352808 G/C cg09835421 chr16:68378352 PRMT7 -0.84 -8.39 -0.42 1.38e-15 Schizophrenia; LUSC cis rs780094 0.500 rs12473139 chr2:27765587 T/C cg27432699 chr2:27873401 GPN1 0.41 5.7 0.3 2.69e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs10782582 0.609 rs5745485 chr1:76349534 C/G cg10523679 chr1:76189770 ACADM -0.45 -6.52 -0.34 2.53e-10 Daytime sleep phenotypes; LUSC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg11062466 chr8:58055876 NA 0.67 8.14 0.41 7.83e-15 Developmental language disorder (linguistic errors); LUSC trans rs3960554 0.741 rs10232162 chr7:75702505 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 9.5 0.46 4.12e-19 Eotaxin levels; LUSC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.85 -0.39 5.57e-14 Reticulocyte count; LUSC cis rs9653442 0.545 rs4850921 chr2:100762699 G/T cg07810366 chr2:100720526 AFF3 -0.44 -7.55 -0.38 4.3e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7917772 0.582 rs4919665 chr10:104366042 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.67 -10.85 -0.51 1.09e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs713477 1.000 rs12886860 chr14:55911150 G/C cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs897984 0.542 rs59061704 chr16:31062704 G/C cg02466173 chr16:30829666 NA -0.52 -9.94 -0.48 1.42e-20 Dementia with Lewy bodies; LUSC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11890956 chr21:40555474 PSMG1 1.05 21.7 0.76 9.2e-66 Cognitive function; LUSC trans rs6600671 0.934 rs7528274 chr1:121286901 A/T cg08727972 chr1:148025634 NBPF14 0.44 6.03 0.31 4.46e-9 Hip geometry; LUSC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg06713675 chr4:122721982 EXOSC9 -0.47 -8.23 -0.41 4.19e-15 Type 2 diabetes; LUSC cis rs654950 0.776 rs2759254 chr1:42035683 G/C cg06885757 chr1:42089581 HIVEP3 -0.43 -8.49 -0.42 7.03e-16 Airway imaging phenotypes; LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7824557 0.767 rs6985146 chr8:11170721 A/C cg21293242 chr8:11204541 TDH 0.34 6.18 0.32 1.81e-9 Retinal vascular caliber; LUSC cis rs34779708 0.931 rs35317849 chr10:35285721 C/A cg04310649 chr10:35416472 CREM -0.44 -6.56 -0.34 2.03e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg27539214 chr16:67997921 SLC12A4 -0.58 -7.64 -0.39 2.32e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs394563 0.517 rs385303 chr6:149779064 C/T cg07828024 chr6:149772892 ZC3H12D -0.45 -9.17 -0.45 5.11e-18 Dupuytren's disease; LUSC cis rs12900413 0.687 rs13343254 chr15:90311283 G/A cg24249390 chr15:90295951 MESP1 -0.37 -5.91 -0.31 8.6e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs8002861 0.619 rs1337203 chr13:44423621 T/G cg12856521 chr11:46389249 DGKZ 0.43 6.44 0.33 4.28e-10 Leprosy; LUSC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.84 -0.3 1.26e-8 Vitiligo; LUSC cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg05340658 chr4:99064831 C4orf37 0.57 9.54 0.46 3.04e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg06634786 chr22:41940651 POLR3H -0.55 -6.46 -0.33 3.75e-10 Vitiligo; LUSC cis rs6433857 0.536 rs12464424 chr2:181349137 A/G cg23363182 chr2:181467187 NA -0.43 -6.89 -0.35 2.73e-11 Body mass index; LUSC cis rs62458065 0.568 rs62466415 chr7:32518254 C/T cg20159608 chr7:32802032 NA -0.71 -8.62 -0.43 2.77e-16 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9359856 0.623 rs1179906 chr6:90323624 T/C cg13799429 chr6:90582589 CASP8AP2 -0.82 -10.23 -0.49 1.51e-21 Bipolar disorder; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.44 0.53 8.79e-26 Prudent dietary pattern; LUSC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg04455712 chr21:45112962 RRP1B 0.49 9.19 0.45 4.28e-18 Mean corpuscular volume; LUSC cis rs17818399 0.533 rs13420857 chr2:46798005 C/G cg26688816 chr2:46740690 ATP6V1E2 0.48 7.08 0.36 8.81e-12 Height; LUSC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg06640241 chr16:89574553 SPG7 0.73 10.3 0.49 8.45e-22 Multiple myeloma (IgH translocation); LUSC cis rs2806561 0.734 rs667211 chr1:23516142 T/C cg12483005 chr1:23474871 LUZP1 0.41 6.5 0.34 2.89e-10 Height; LUSC trans rs7556950 0.572 rs61552231 chr2:41931799 T/C cg13792581 chr20:43590115 TOMM34 0.77 6.26 0.32 1.17e-9 Major depression and alcohol dependence; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg11062466 chr8:58055876 NA 0.7 8.92 0.44 3.22e-17 Developmental language disorder (linguistic errors); LUSC cis rs983392 0.617 rs617135 chr11:59936757 A/G cg20284999 chr11:59952153 MS4A6A -0.32 -5.72 -0.3 2.33e-8 Alzheimer's disease (late onset); LUSC cis rs826838 0.935 rs1843639 chr12:39178919 C/A cg13010199 chr12:38710504 ALG10B 0.7 11.94 0.55 1.35e-27 Heart rate; LUSC cis rs9640161 0.750 rs3735169 chr7:150034378 A/G cg27494647 chr7:150038898 RARRES2 0.57 8.55 0.42 4.64e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs1949733 1.000 rs1949733 chr4:8503359 C/T cg11789530 chr4:8429930 ACOX3 -0.58 -8.69 -0.43 1.64e-16 Response to antineoplastic agents; LUSC cis rs2180341 0.618 rs12199451 chr6:127597780 C/G cg24812749 chr6:127587940 RNF146 0.6 8.9 0.44 3.54e-17 Breast cancer; LUSC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg21017887 chr14:105400489 NA 0.7 13.2 0.59 2.69e-32 Rheumatoid arthritis; LUSC cis rs2346177 0.844 rs34712412 chr2:46652428 G/A cg02822958 chr2:46747628 ATP6V1E2 0.36 6.19 0.32 1.75e-9 HDL cholesterol; LUSC cis rs929596 0.563 rs1105880 chr2:234601965 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -6.82 -0.35 4.19e-11 Total bilirubin levels in HIV-1 infection; LUSC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.86 11.0 0.52 3.16e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10979 0.965 rs7754452 chr6:143889028 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC cis rs7202877 0.706 rs247423 chr16:75456631 C/A cg04384234 chr16:75411784 CFDP1 0.69 9.64 0.47 1.43e-19 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.42e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs7572644 0.662 rs9309658 chr2:28256831 A/G cg27432699 chr2:27873401 GPN1 -0.52 -7.07 -0.36 9.22e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg07148914 chr20:33460835 GGT7 -0.53 -8.1 -0.41 1.05e-14 Glomerular filtration rate (creatinine); LUSC cis rs62400317 0.859 rs1324536 chr6:45116261 C/T cg18551225 chr6:44695536 NA 0.35 5.68 0.3 2.86e-8 Total body bone mineral density; LUSC cis rs9929218 1.000 rs9937664 chr16:68784603 T/C cg02972257 chr16:68554789 NA 0.42 5.68 0.3 3.01e-8 Colorectal cancer; LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg00684032 chr4:1343700 KIAA1530 0.35 6.23 0.32 1.37e-9 Longevity; LUSC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg18230493 chr5:56204884 C5orf35 -0.61 -9.72 -0.47 7.75e-20 Coronary artery disease; LUSC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs9788721 0.836 rs2568494 chr15:78740964 G/A cg18825076 chr15:78729989 IREB2 -0.6 -9.84 -0.47 3.17e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9309473 0.519 rs2421670 chr2:73886661 T/G cg20560298 chr2:73613845 ALMS1 0.48 7.31 0.37 1.97e-12 Metabolite levels; LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs1419980 0.673 rs1978284 chr12:7771151 G/A cg10578777 chr12:7781093 NA 0.57 6.31 0.33 8.68e-10 HDL cholesterol levels; LUSC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.8 0.63 1.84e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg20243544 chr17:37824526 PNMT -0.46 -5.67 -0.3 3.1e-8 Glomerular filtration rate (creatinine); LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg09704166 chr2:114031854 PAX8;LOC440839 0.49 7.34 0.37 1.67e-12 Renal function-related traits (BUN); LUSC cis rs8114671 0.967 rs1415774 chr20:33765616 C/T cg07148914 chr20:33460835 GGT7 -0.44 -6.54 -0.34 2.25e-10 Height; LUSC cis rs7647973 0.667 rs9869256 chr3:49624095 T/G cg03060546 chr3:49711283 APEH 0.65 6.77 0.35 5.86e-11 Menarche (age at onset); LUSC cis rs1712517 1.000 rs1163084 chr10:105039048 T/C cg05636881 chr10:105038444 INA 0.39 6.63 0.34 1.32e-10 Migraine; LUSC trans rs61931739 0.817 rs304313 chr12:34216898 C/T cg26384229 chr12:38710491 ALG10B 0.54 8.67 0.43 1.9e-16 Morning vs. evening chronotype; LUSC cis rs8014204 0.566 rs7145575 chr14:75145528 T/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.01 0.4 1.88e-14 Caffeine consumption; LUSC cis rs394563 0.591 rs237026 chr6:149720681 G/A cg11245181 chr6:149772854 ZC3H12D -0.29 -6.2 -0.32 1.63e-9 Dupuytren's disease; LUSC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg19077165 chr18:44547161 KATNAL2 0.39 5.88 0.31 9.96e-9 Personality dimensions; LUSC cis rs7674212 0.541 rs2720464 chr4:104073201 G/A cg16532752 chr4:104119610 CENPE -0.46 -6.45 -0.33 4.02e-10 Type 2 diabetes; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg10150615 chr22:24372951 LOC391322 -0.42 -6.91 -0.35 2.51e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs11958404 0.932 rs112683473 chr5:157437819 T/C cg05962755 chr5:157440814 NA 0.53 6.3 0.33 9.34e-10 IgG glycosylation; LUSC cis rs59698941 0.765 rs67045943 chr5:132219956 C/T cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.45e-11 Apolipoprotein A-IV levels; LUSC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg02079420 chr8:82753780 SNX16 0.41 7.1 0.36 7.48e-12 Diastolic blood pressure; LUSC cis rs7937682 0.889 rs11213971 chr11:111529829 A/G cg19812747 chr11:111475976 SIK2 -0.49 -7.0 -0.36 1.4e-11 Primary sclerosing cholangitis; LUSC cis rs35146811 0.735 rs1138417 chr7:99807146 C/G cg22906224 chr7:99728672 NA -0.48 -6.68 -0.34 9.94e-11 Coronary artery disease; LUSC cis rs9326248 0.581 rs12225187 chr11:116793231 G/A cg26566898 chr11:117069891 TAGLN 0.37 7.06 0.36 9.8e-12 Blood protein levels; LUSC cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg04455712 chr21:45112962 RRP1B 0.47 8.64 0.43 2.38e-16 Mean corpuscular volume; LUSC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg13683864 chr3:40499215 RPL14 -1.14 -21.28 -0.76 3.98e-64 Renal cell carcinoma; LUSC cis rs61931739 0.500 rs3934517 chr12:34451396 T/C cg06521331 chr12:34319734 NA -0.41 -6.74 -0.35 6.92e-11 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.18 0.45 4.55e-18 Prudent dietary pattern; LUSC cis rs9788682 0.947 rs12439240 chr15:78829091 T/C cg18825076 chr15:78729989 IREB2 0.46 6.16 0.32 2.07e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs422249 0.727 rs174606 chr11:61626973 G/T cg06860612 chr11:61641270 FADS3 0.28 5.74 0.3 2.15e-8 Trans fatty acid levels; LUSC cis rs1178968 0.901 rs7783232 chr7:72765171 C/G cg25889504 chr7:72793014 NA 0.6 7.82 0.39 6.99e-14 Triglyceride levels; LUSC trans rs8072100 0.701 rs6503807 chr17:45772932 T/C cg04995722 chr7:26192034 NFE2L3 -0.42 -6.3 -0.33 9.5e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg12292205 chr6:26970375 C6orf41 0.51 8.57 0.42 3.88e-16 Schizophrenia; LUSC trans rs4332037 0.624 rs11764337 chr7:1892309 A/G cg10840412 chr1:235813424 GNG4 -0.45 -6.33 -0.33 7.83e-10 Bipolar disorder; LUSC trans rs453301 0.624 rs330049 chr8:9087299 C/T cg15556689 chr8:8085844 FLJ10661 0.48 7.05 0.36 1.06e-11 Joint mobility (Beighton score); LUSC cis rs7772486 0.875 rs2777481 chr6:146310036 G/T cg23711669 chr6:146136114 FBXO30 0.86 15.13 0.64 9.49e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs950776 0.593 rs680244 chr15:78871288 T/C cg22563815 chr15:78856949 CHRNA5 -0.25 -6.13 -0.32 2.44e-9 Sudden cardiac arrest; LUSC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg09955084 chr16:413813 NA 0.29 6.21 0.32 1.59e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs7917772 0.582 rs7091252 chr10:104328859 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs79349575 0.749 rs1057902 chr17:47005588 C/T cg22482690 chr17:47019901 SNF8 0.39 7.43 0.38 9.3e-13 Type 2 diabetes; LUSC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 6.03 0.31 4.41e-9 Intelligence (multi-trait analysis); LUSC cis rs1775715 0.677 rs2799034 chr10:32175896 A/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.84 0.39 6.07e-14 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs6582630 0.502 rs4385963 chr12:38295264 G/A cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg04518342 chr5:131593106 PDLIM4 0.47 8.53 0.42 5.3e-16 Blood metabolite levels; LUSC cis rs11250098 0.541 rs6997997 chr8:10766082 T/C cg27411982 chr8:10470053 RP1L1 -0.46 -6.83 -0.35 4.03e-11 Morning vs. evening chronotype; LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03352830 chr11:487213 PTDSS2 0.69 8.38 0.42 1.45e-15 Body mass index; LUSC cis rs2073300 1.000 rs17830565 chr20:23444805 G/A cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs67460515 0.892 rs34016896 chr3:160992864 C/T cg03342759 chr3:160939853 NMD3 -0.54 -7.93 -0.4 3.37e-14 Parkinson's disease; LUSC cis rs11098499 0.863 rs3736115 chr4:120488703 A/G cg09307838 chr4:120376055 NA -0.73 -10.72 -0.51 3.18e-23 Corneal astigmatism; LUSC cis rs965469 0.947 rs4611719 chr20:3228423 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -6.02 -0.31 4.62e-9 IFN-related cytopenia; LUSC cis rs6840360 1.000 rs6535814 chr4:152609694 A/G cg22705602 chr4:152727874 NA -0.31 -6.6 -0.34 1.58e-10 Intelligence (multi-trait analysis); LUSC trans rs35110281 0.693 rs11089093 chr21:45121161 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.66 0.5 4.89e-23 Mean corpuscular volume; LUSC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg01181863 chr3:195395398 SDHAP2 -0.61 -8.32 -0.41 2.21e-15 Pancreatic cancer; LUSC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg17252645 chr8:143867129 LY6D -0.33 -6.16 -0.32 2.09e-9 Urinary tract infection frequency; LUSC cis rs7829975 0.557 rs7816427 chr8:8545884 T/C cg18904891 chr8:8559673 CLDN23 -0.39 -5.75 -0.3 2e-8 Mood instability; LUSC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.19 -0.41 5.78e-15 Lung cancer; LUSC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.76e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10492096 0.947 rs10849482 chr12:6635274 G/A cg13857086 chr12:6580257 VAMP1 0.64 7.69 0.39 1.64e-13 Hip geometry; LUSC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg24829409 chr8:58192753 C8orf71 -0.46 -5.72 -0.3 2.39e-8 Developmental language disorder (linguistic errors); LUSC cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg21573476 chr21:45109991 RRP1B -0.4 -6.26 -0.32 1.19e-9 Mean corpuscular volume; LUSC trans rs6502050 0.769 rs9916231 chr17:80119645 A/G cg07393940 chr7:158741817 NA 0.34 5.98 0.31 5.7e-9 Life satisfaction; LUSC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg24250549 chr1:154909240 PMVK 0.66 10.99 0.52 3.44e-24 Prostate cancer; LUSC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg20243544 chr17:37824526 PNMT 0.59 8.49 0.42 6.77e-16 Asthma; LUSC cis rs4930103 0.534 rs2063550 chr11:1979223 G/C cg23202291 chr11:1979235 NA 0.54 8.89 0.44 3.99e-17 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg19318889 chr4:1322082 MAEA -0.71 -12.36 -0.56 3.73e-29 Obesity-related traits; LUSC cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg05340658 chr4:99064831 C4orf37 0.57 9.54 0.46 3.03e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs733592 0.507 rs7299704 chr12:48444488 A/G cg24011408 chr12:48396354 COL2A1 0.53 8.76 0.43 9.88e-17 Plateletcrit; LUSC cis rs7824557 0.545 rs34482136 chr8:11227885 C/T cg21775007 chr8:11205619 TDH -0.7 -10.87 -0.51 9.1e-24 Retinal vascular caliber; LUSC cis rs13223928 0.516 rs1872880 chr7:3148389 G/C cg19214707 chr7:3157722 NA -0.46 -8.54 -0.42 4.65e-16 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs3812831 0.695 rs6560936 chr13:114945972 C/T cg15896084 chr13:114927664 NA -0.38 -6.9 -0.35 2.62e-11 Schizophrenia; LUSC cis rs2486288 0.656 rs11629859 chr15:45547121 T/G cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.4e-10 Glomerular filtration rate; LUSC cis rs2197308 0.765 rs10880643 chr12:37926452 C/T cg13010199 chr12:38710504 ALG10B -0.6 -9.33 -0.45 1.56e-18 Morning vs. evening chronotype; LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg03395511 chr6:291903 DUSP22 -0.46 -6.72 -0.35 7.64e-11 Menopause (age at onset); LUSC cis rs12599106 0.792 rs11648801 chr16:34360980 C/T cg01585723 chr16:33734837 NA 0.36 5.85 0.3 1.16e-8 Menopause (age at onset); LUSC cis rs9457247 1.000 rs421214 chr6:167396629 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.75 -0.35 6.51e-11 Crohn's disease; LUSC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg03161606 chr19:29218774 NA -0.52 -6.44 -0.33 4.06e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs4242434 0.927 rs746011 chr8:22457804 C/T cg03733263 chr8:22462867 KIAA1967 1.02 18.64 0.71 1.13e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg06092702 chr1:163392909 NA 0.43 7.3 0.37 2.06e-12 Motion sickness; LUSC cis rs1190552 0.846 rs11623570 chr14:102959277 G/T cg18135206 chr14:102964638 TECPR2 0.46 5.81 0.3 1.49e-8 Blood protein levels; LUSC cis rs9326248 0.581 rs10892061 chr11:116886114 C/T cg20608306 chr11:116969690 SIK3 0.37 6.94 0.35 2.1e-11 Blood protein levels; LUSC cis rs1538970 0.504 rs3790585 chr1:46023356 A/T cg06784218 chr1:46089804 CCDC17 0.52 7.7 0.39 1.53e-13 Platelet count; LUSC cis rs17095355 1.000 rs11194933 chr10:111725862 T/C cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.44 -0.38 8.8e-13 Biliary atresia; LUSC cis rs921968 0.565 rs13412324 chr2:219620521 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs2050392 0.517 rs602966 chr10:30755853 C/T cg25182066 chr10:30743637 MAP3K8 -0.45 -6.82 -0.35 4.27e-11 Inflammatory bowel disease; LUSC cis rs4665630 0.764 rs2098769 chr2:23891540 C/T cg08063864 chr2:24346004 PFN4;LOC375190 -0.55 -5.65 -0.3 3.46e-8 Hypertension; LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg24675658 chr1:53192096 ZYG11B -0.58 -8.73 -0.43 1.21e-16 Monocyte count; LUSC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg13206674 chr6:150067644 NUP43 0.62 10.08 0.48 4.87e-21 Lung cancer; LUSC cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7103648 0.569 rs11039266 chr11:47532395 T/G cg20307385 chr11:47447363 PSMC3 0.82 11.3 0.53 2.78e-25 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs968567 0.705 rs174572 chr11:61598288 C/T cg19610905 chr11:61596333 FADS2 -0.43 -5.88 -0.31 9.75e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg03354898 chr7:1950403 MAD1L1 -0.3 -5.92 -0.31 8.1e-9 Bipolar disorder and schizophrenia; LUSC trans rs2285002 0.745 rs229674 chr14:65281472 G/C cg27302963 chr3:184322008 NA -0.29 -5.97 -0.31 6.09e-9 Red cell distribution width; LUSC cis rs2652834 0.750 rs11637947 chr15:63397538 C/T cg05507819 chr15:63340323 TPM1 0.55 7.07 0.36 8.99e-12 HDL cholesterol; LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg12143784 chr7:64541923 NA 0.44 6.81 0.35 4.49e-11 Calcium levels; LUSC cis rs11098499 0.604 rs34278750 chr4:120571136 G/A cg24375607 chr4:120327624 NA 0.71 10.36 0.49 5.29e-22 Corneal astigmatism; LUSC cis rs36093844 0.752 rs75639684 chr11:85571576 A/G cg25872744 chr11:85566296 CCDC83 -0.45 -5.78 -0.3 1.69e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs977987 0.735 rs166013 chr16:75434146 C/T cg04384234 chr16:75411784 CFDP1 0.46 7.11 0.36 7.18e-12 Dupuytren's disease; LUSC cis rs11608355 1.000 rs7970482 chr12:109862335 G/A cg19025524 chr12:109796872 NA -0.38 -5.94 -0.31 7.28e-9 Neuroticism; LUSC cis rs6977660 0.714 rs10257947 chr7:19824099 A/C cg07541023 chr7:19748670 TWISTNB 0.61 6.4 0.33 5.2400000000000005e-10 Thyroid stimulating hormone; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg12564285 chr5:131593104 PDLIM4 0.46 8.86 0.44 4.99e-17 Blood metabolite levels; LUSC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg18252515 chr7:66147081 NA -1.25 -13.96 -0.61 3.34e-35 Diabetic kidney disease; LUSC cis rs4343996 0.870 rs6974257 chr7:3392195 A/G cg21248987 chr7:3385318 SDK1 -0.4 -6.77 -0.35 5.71e-11 Motion sickness; LUSC cis rs72781680 0.821 rs72790304 chr2:24108557 G/A cg08917208 chr2:24149416 ATAD2B 0.62 6.81 0.35 4.62e-11 Lymphocyte counts; LUSC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg17971929 chr21:40555470 PSMG1 -0.49 -7.39 -0.37 1.21e-12 Menarche (age at onset); LUSC cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg24642439 chr20:33292090 TP53INP2 -0.39 -5.79 -0.3 1.65e-8 Glomerular filtration rate (creatinine); LUSC trans rs1922233 0.943 rs1922216 chr4:92366263 A/G cg24250684 chr1:219729030 NA -0.32 -6.0 -0.31 5.17e-9 Gut microbiome composition (summer and winter); LUSC cis rs2439831 0.867 rs2278860 chr15:43659046 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.86 -9.31 -0.45 1.81e-18 Lung cancer in ever smokers; LUSC cis rs11018904 0.906 rs61903722 chr11:89967042 C/T cg26834418 chr11:89957033 CHORDC1 -0.5 -6.35 -0.33 7.02e-10 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.11e-21 Bladder cancer; LUSC cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg11584989 chr19:19387371 SF4 -0.59 -6.68 -0.34 1e-10 Bipolar disorder; LUSC trans rs7980799 0.654 rs1482987 chr12:33614283 G/C cg13010199 chr12:38710504 ALG10B -0.43 -6.35 -0.33 7.23e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg12963246 chr6:28129442 ZNF389 0.52 7.18 0.37 4.53e-12 Depression; LUSC cis rs524023 1.000 rs10897518 chr11:64360705 A/G cg19131476 chr11:64387923 NRXN2 0.38 10.31 0.49 8.05e-22 Urate levels in obese individuals; LUSC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg23324259 chr8:82754387 SNX16 -0.43 -5.65 -0.3 3.48e-8 Diastolic blood pressure; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg04267008 chr7:1944627 MAD1L1 -0.51 -7.68 -0.39 1.8e-13 Bipolar disorder and schizophrenia; LUSC cis rs12532214 0.617 rs76620680 chr7:3160046 C/A cg19214707 chr7:3157722 NA -0.47 -7.46 -0.38 7.75e-13 Itch intensity from mosquito bite; LUSC cis rs2404602 0.735 rs4886493 chr15:76679026 A/G cg23625390 chr15:77176239 SCAPER -0.6 -9.58 -0.46 2.37e-19 Blood metabolite levels; LUSC cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg27279351 chr12:120934652 DYNLL1 0.63 8.41 0.42 1.21e-15 High light scatter reticulocyte count; LUSC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.19 0.49 2.13e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg10523860 chr14:103875565 MARK3 -0.37 -5.92 -0.31 8.18e-9 Body mass index; LUSC cis rs10088262 0.629 rs12541177 chr8:124800273 G/T cg20713898 chr8:124780851 FAM91A1 -0.54 -7.52 -0.38 5.18e-13 Pancreatic cancer; LUSC trans rs11098499 0.954 rs9993199 chr4:120392873 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.45 -6.17 -0.32 2.01e-9 Corneal astigmatism; LUSC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg18230493 chr5:56204884 C5orf35 -0.58 -9.34 -0.46 1.36e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs847577 0.609 rs34320230 chr7:97785500 C/T cg24562669 chr7:97807699 LMTK2 0.48 8.76 0.43 1.01e-16 Breast cancer; LUSC cis rs4843185 0.669 rs889502 chr16:85716832 A/G cg00168118 chr16:85669675 KIAA0182 0.38 5.86 0.31 1.14e-8 Platelet distribution width; LUSC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3087591 0.919 rs2072131 chr17:29559588 G/C cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.15 -0.41 7.32e-15 Hip circumference; LUSC cis rs6121246 0.567 rs6060249 chr20:30190944 G/A cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg16006841 chr5:176797999 RGS14 0.66 10.6 0.5 7.88e-23 Hemoglobin concentration;Hematocrit; LUSC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg16928487 chr17:17741425 SREBF1 -0.42 -8.21 -0.41 4.86e-15 Total body bone mineral density; LUSC cis rs7580658 0.864 rs34832797 chr2:128119441 T/C cg09760422 chr2:128146352 NA -0.3 -6.36 -0.33 6.57e-10 Protein C levels; LUSC cis rs4555082 1.000 rs4555082 chr14:105758964 C/T cg10792982 chr14:105748885 BRF1 0.46 8.16 0.41 6.69e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs8060686 0.545 rs10500543 chr16:68281311 T/C cg05110241 chr16:68378359 PRMT7 -0.69 -7.31 -0.37 2.01e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs734999 0.524 rs4648448 chr1:2695687 C/T cg18932078 chr1:2524107 MMEL1 0.29 6.24 0.32 1.33e-9 Ulcerative colitis; LUSC cis rs7267979 1.000 rs6050631 chr20:25431749 C/T cg08601574 chr20:25228251 PYGB 0.44 6.78 0.35 5.3e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg03806693 chr22:41940476 POLR3H -0.87 -12.23 -0.56 1.1e-28 Vitiligo; LUSC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg22823121 chr1:150693482 HORMAD1 -0.45 -6.7 -0.34 8.88e-11 Tonsillectomy; LUSC cis rs7666738 0.716 rs11097615 chr4:99092773 T/C cg05340658 chr4:99064831 C4orf37 0.59 9.58 0.46 2.28e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7927771 0.524 rs12421563 chr11:47780222 G/A cg20307385 chr11:47447363 PSMC3 -0.44 -6.61 -0.34 1.51e-10 Subjective well-being; LUSC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC trans rs11088226 0.681 rs11702499 chr21:33938565 C/T cg09050820 chr6:167586206 TCP10L2 0.73 9.47 0.46 5.31e-19 Gastritis; LUSC cis rs3806843 0.576 rs246021 chr5:140334504 C/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg13531842 chr10:38383804 ZNF37A 0.45 6.95 0.36 1.96e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg21171335 chr12:122356390 WDR66 0.65 9.63 0.47 1.52e-19 Mean corpuscular volume; LUSC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg06636001 chr8:8085503 FLJ10661 -0.62 -9.61 -0.47 1.89e-19 Mood instability; LUSC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg15445000 chr17:37608096 MED1 -0.39 -6.67 -0.34 1.05e-10 Glomerular filtration rate (creatinine); LUSC cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs9463078 0.817 rs3799967 chr6:44798701 A/G cg25276700 chr6:44698697 NA -0.29 -5.84 -0.3 1.26e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg01448562 chr3:133502909 NA -0.46 -7.31 -0.37 2.01e-12 Iron status biomarkers; LUSC cis rs7605827 0.754 rs13017772 chr2:15699660 A/T cg19274914 chr2:15703543 NA 0.47 9.07 0.44 1.04e-17 Educational attainment (years of education); LUSC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg26850624 chr5:429559 AHRR -0.42 -8.21 -0.41 4.79e-15 Cystic fibrosis severity; LUSC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg03538708 chr1:25844672 NA 0.37 6.22 0.32 1.51e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg07636037 chr3:49044803 WDR6 1.03 18.01 0.7 3.7700000000000003e-51 Parkinson's disease; LUSC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg03609598 chr5:56110824 MAP3K1 -0.44 -6.44 -0.33 4.27e-10 Initial pursuit acceleration; LUSC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg13798780 chr7:105162888 PUS7 0.56 6.09 0.32 3.05e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg15556689 chr8:8085844 FLJ10661 0.55 8.74 0.43 1.18e-16 Mood instability; LUSC cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg09165964 chr15:75287851 SCAMP5 0.47 6.88 0.35 2.89e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs10927875 0.550 rs12121918 chr1:16183556 C/A cg21385522 chr1:16154831 NA -0.87 -12.57 -0.57 6.19e-30 Dilated cardiomyopathy; LUSC cis rs17433780 0.928 rs12127787 chr1:89458761 T/C cg09516651 chr1:89888402 LOC400759 0.49 8.13 0.41 8.65e-15 Carotid intima media thickness; LUSC cis rs4808199 0.901 rs11669516 chr19:19532682 G/A cg03709012 chr19:19516395 GATAD2A 1.13 15.07 0.64 1.58e-39 Nonalcoholic fatty liver disease; LUSC cis rs9341808 0.644 rs76102095 chr6:80942026 G/C cg08355045 chr6:80787529 NA -0.42 -7.13 -0.36 6.17e-12 Sitting height ratio; LUSC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08109568 chr15:31115862 NA -0.59 -8.28 -0.41 2.99e-15 Huntington's disease progression; LUSC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg02807482 chr3:125708958 NA -0.53 -7.03 -0.36 1.18e-11 Blood pressure (smoking interaction); LUSC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg18404041 chr3:52824283 ITIH1 0.55 9.1 0.45 8.6e-18 Schizophrenia; LUSC cis rs67311347 0.713 rs4974018 chr3:40307419 G/A cg09455208 chr3:40491958 NA 0.5 9.37 0.46 1.16e-18 Renal cell carcinoma; LUSC cis rs7246657 0.943 rs28402338 chr19:37833923 G/A cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg23158103 chr7:148848205 ZNF398 -0.45 -7.14 -0.36 5.77e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2115630 1.000 rs10220733 chr15:85280864 G/A cg09876464 chr15:85330779 ZNF592 0.36 6.66 0.34 1.14e-10 P wave terminal force; LUSC cis rs7267979 0.565 rs6076364 chr20:25556801 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.7 -12.69 -0.57 2.26e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs34779708 0.931 rs35126129 chr10:35452141 G/A cg03585969 chr10:35415529 CREM 0.62 9.07 0.44 1.01e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1018836 0.770 rs4324886 chr8:91651943 A/G cg16814680 chr8:91681699 NA -0.88 -15.75 -0.65 3.53e-42 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs2708377 0.858 rs4763632 chr12:11307278 A/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.56 -0.38 3.9e-13 Bipolar disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg12977448 chr10:14920832 SUV39H2 -0.44 -6.22 -0.32 1.47e-9 Hepatitis; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg11905131 chr22:24372483 LOC391322 0.51 8.2 0.41 5.32e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg11062466 chr8:58055876 NA 0.76 9.09 0.45 9.22e-18 Developmental language disorder (linguistic errors); LUSC trans rs8072100 1.000 rs4375701 chr17:45712218 C/T cg04995722 chr7:26192034 NFE2L3 -0.37 -6.06 -0.31 3.67e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs950027 0.620 rs1153860 chr15:45636584 A/G cg04036182 chr15:45458818 NA -0.35 -5.98 -0.31 5.6e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4268898 0.722 rs12185638 chr2:24382030 C/G cg06627628 chr2:24431161 ITSN2 0.54 7.47 0.38 7.13e-13 Asthma; LUSC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 9.12 0.45 6.99e-18 Tonsillectomy; LUSC cis rs11674184 0.714 rs16857668 chr2:11723110 G/A cg07314298 chr2:11723111 GREB1 -0.81 -15.16 -0.64 6.89e-40 Endometriosis; LUSC cis rs7180079 0.620 rs4777571 chr15:65055182 C/G cg08069370 chr15:64387884 SNX1 0.49 5.71 0.3 2.54e-8 Monocyte count; LUSC cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs559928 1.000 rs7105178 chr11:64145109 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.6 -6.46 -0.33 3.77e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg20203395 chr5:56204925 C5orf35 -0.72 -9.78 -0.47 5.14e-20 Initial pursuit acceleration; LUSC trans rs1814175 0.817 rs1615305 chr11:49895222 T/A cg03929089 chr4:120376271 NA -1.03 -20.21 -0.74 7.12e-60 Height; LUSC cis rs6964587 0.839 rs12536702 chr7:91471576 G/C cg17063962 chr7:91808500 NA 0.57 8.74 0.43 1.15e-16 Breast cancer; LUSC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg06634786 chr22:41940651 POLR3H -0.55 -6.39 -0.33 5.42e-10 Vitiligo; LUSC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg23283495 chr1:209979779 IRF6 0.64 9.35 0.46 1.26e-18 Cleft lip with or without cleft palate; LUSC cis rs17401966 0.898 rs12117635 chr1:10317445 C/T cg19773385 chr1:10388646 KIF1B -0.51 -8.88 -0.44 4.33e-17 Hepatocellular carcinoma; LUSC cis rs9733 0.744 rs2089081 chr1:150800117 T/C cg13175981 chr1:150552382 MCL1 0.43 6.15 0.32 2.26e-9 Tonsillectomy; LUSC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs9341835 0.740 rs9294198 chr6:64136993 T/C cg03326410 chr6:64151739 NA -0.37 -6.16 -0.32 2.09e-9 Schizophrenia; LUSC cis rs9399135 0.967 rs1014020 chr6:135334426 C/A cg22676075 chr6:135203613 NA 0.48 7.48 0.38 6.5e-13 Red blood cell count; LUSC cis rs7605827 0.930 rs4668450 chr2:15675011 C/T cg19274914 chr2:15703543 NA 0.45 8.7 0.43 1.49e-16 Educational attainment (years of education); LUSC cis rs4423214 0.592 rs10898186 chr11:71188800 G/A cg05163923 chr11:71159392 DHCR7 -0.7 -7.29 -0.37 2.32e-12 Vitamin D levels; LUSC cis rs804280 0.564 rs4639 chr8:11644751 A/G cg12395012 chr8:11607386 GATA4 -0.31 -6.04 -0.31 4.1e-9 Myopia (pathological); LUSC trans rs11782517 0.883 rs12544801 chr8:10107382 C/G cg15556689 chr8:8085844 FLJ10661 0.52 6.89 0.35 2.73e-11 Nose size; LUSC cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg27432699 chr2:27873401 GPN1 -0.58 -8.67 -0.43 1.92e-16 Total body bone mineral density; LUSC cis rs28647808 0.881 rs4549850 chr9:136265239 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.89 0.35 2.73e-11 Blood protein levels; LUSC trans rs9329221 0.572 rs4841295 chr8:10105115 C/T cg06636001 chr8:8085503 FLJ10661 0.48 6.85 0.35 3.54e-11 Neuroticism; LUSC cis rs3744061 0.557 rs2098093 chr17:74646469 G/C cg27546012 chr17:74684504 MXRA7 -0.36 -6.23 -0.32 1.43e-9 Retinal arteriolar caliber; LUSC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg22857025 chr5:266934 NA -1.14 -15.68 -0.65 6.61e-42 Breast cancer; LUSC cis rs4499344 0.730 rs405858 chr19:33106621 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.77 -12.3 -0.56 6.48e-29 Mean platelet volume; LUSC cis rs11958404 0.615 rs7704746 chr5:157450601 C/G cg05962755 chr5:157440814 NA 0.39 5.71 0.3 2.53e-8 IgG glycosylation; LUSC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg02187348 chr16:89574699 SPG7 0.5 7.92 0.4 3.62e-14 Multiple myeloma (IgH translocation); LUSC cis rs6496667 0.533 rs2589949 chr15:90955015 C/T cg10434728 chr15:90938212 IQGAP1 0.33 6.45 0.33 3.81e-10 Rheumatoid arthritis; LUSC cis rs611744 0.647 rs7015240 chr8:109262204 G/A cg18478394 chr8:109455254 TTC35 0.42 6.51 0.34 2.79e-10 Dupuytren's disease; LUSC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg14440974 chr22:39074834 NA -0.35 -5.86 -0.31 1.11e-8 Menopause (age at onset); LUSC cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg17892150 chr10:133769511 PPP2R2D -0.65 -9.02 -0.44 1.53e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg10253484 chr15:75165896 SCAMP2 -0.49 -7.29 -0.37 2.33e-12 Breast cancer; LUSC cis rs7577696 0.785 rs11694630 chr2:32376201 G/A cg02381751 chr2:32503542 YIPF4 -0.43 -6.07 -0.32 3.43e-9 Inflammatory biomarkers; LUSC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.29 -5.86 -0.31 1.1e-8 Cognitive function; LUSC cis rs829880 0.558 rs249817 chr12:98896910 T/A cg25150519 chr12:98850993 NA 0.44 5.65 0.3 3.52e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg07936489 chr17:37558343 FBXL20 0.71 9.88 0.48 2.23e-20 Glomerular filtration rate (creatinine); LUSC cis rs1982963 0.901 rs2516589 chr14:52512610 A/G cg10843707 chr14:52510701 NID2 -0.38 -6.68 -0.34 1.02e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6120849 0.754 rs6120797 chr20:33606002 G/A cg24642439 chr20:33292090 TP53INP2 0.62 6.82 0.35 4.29e-11 Protein C levels; LUSC cis rs10782582 0.593 rs4638068 chr1:76161663 G/A cg10523679 chr1:76189770 ACADM -0.49 -7.26 -0.37 2.66e-12 Daytime sleep phenotypes; LUSC cis rs250677 0.652 rs36045 chr5:148441184 A/G cg18129178 chr5:148520854 ABLIM3 0.7 9.73 0.47 7.29e-20 Breast cancer; LUSC cis rs41271473 1.000 rs41270189 chr1:228878888 C/T cg16512390 chr1:228756714 NA 0.5 6.04 0.31 4.05e-9 Chronic lymphocytic leukemia; LUSC cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9291683 0.552 rs10939656 chr4:10014646 A/C cg00071950 chr4:10020882 SLC2A9 0.61 10.31 0.49 8.33e-22 Bone mineral density; LUSC cis rs7267979 0.966 rs2261698 chr20:25259910 A/G cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.18e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg23158103 chr7:148848205 ZNF398 0.48 8.11 0.41 9.72e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg08859206 chr1:53392774 SCP2 0.51 8.88 0.44 4.07e-17 Monocyte count; LUSC cis rs826838 1.000 rs7299124 chr12:39002661 T/C cg26384229 chr12:38710491 ALG10B 0.93 17.78 0.7 2.99e-50 Heart rate; LUSC cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.89 -0.35 2.71e-11 Monocyte percentage of white cells; LUSC cis rs7772486 0.840 rs2814864 chr6:146345046 A/C cg05347473 chr6:146136440 FBXO30 0.39 6.15 0.32 2.21e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs208520 0.690 rs12202913 chr6:66734198 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.09 16.92 0.68 7.94e-47 Exhaled nitric oxide output; LUSC cis rs2692947 0.726 rs13019188 chr2:96774199 A/G cg22654517 chr2:96458247 NA -0.36 -7.19 -0.37 4.28e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.79 0.35 5.19e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.85 -0.35 3.55e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs11098499 0.954 rs9685777 chr4:120365965 C/A cg24375607 chr4:120327624 NA 0.79 11.77 0.54 5.27e-27 Corneal astigmatism; LUSC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg11062466 chr8:58055876 NA 0.5 6.43 0.33 4.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg00684032 chr4:1343700 KIAA1530 0.38 6.6 0.34 1.63e-10 Obesity-related traits; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg05064044 chr6:292385 DUSP22 -0.72 -11.78 -0.54 4.92e-27 Menopause (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07973470 chr16:47178359 NETO2 0.78 6.39 0.33 5.43e-10 Cognitive performance; LUSC cis rs10744422 0.920 rs3896871 chr12:123333610 G/T cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.14e-12 Schizophrenia; LUSC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg24250549 chr1:154909240 PMVK 0.59 9.45 0.46 6.2800000000000005e-19 Prostate cancer; LUSC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg13944838 chr5:179740914 GFPT2 -0.57 -9.24 -0.45 2.86e-18 Height; LUSC cis rs4820539 1.000 rs5759595 chr22:23471624 G/A cg14186256 chr22:23484241 RTDR1 0.95 18.06 0.7 2.38e-51 Bone mineral density; LUSC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg19592336 chr6:28129416 ZNF389 -0.47 -6.32 -0.33 8.48e-10 Depression; LUSC cis rs9457247 0.765 rs3752520 chr6:167436159 T/C cg23791538 chr6:167370224 RNASET2 -0.37 -5.75 -0.3 2.03e-8 Crohn's disease; LUSC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg16325326 chr1:53192061 ZYG11B 0.96 18.47 0.71 5.49e-53 Monocyte count; LUSC cis rs317689 0.690 rs604168 chr12:69671158 C/T cg11871910 chr12:69753446 YEATS4 0.46 6.12 0.32 2.6e-9 Response to diuretic therapy; LUSC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg01416388 chr22:39784598 NA 0.45 7.62 0.38 2.66e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6942756 1.000 rs56026912 chr7:128913937 A/G cg02491457 chr7:128862824 NA -0.5 -7.1 -0.36 7.68e-12 White matter hyperintensity burden; LUSC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg20476274 chr7:133979776 SLC35B4 0.88 16.9 0.68 1.01e-46 Mean platelet volume; LUSC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.05 0.66 2.2e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.12 0.41 9.01e-15 Homoarginine levels; LUSC trans rs225245 0.817 rs225290 chr17:33927904 C/G cg19694781 chr19:47549865 TMEM160 -0.41 -6.53 -0.34 2.46e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg06784218 chr1:46089804 CCDC17 0.54 10.91 0.51 6.6e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3770081 1.000 rs2278086 chr2:86281905 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.99 -0.36 1.51e-11 Facial emotion recognition (sad faces); LUSC trans rs62238980 0.614 rs74534759 chr22:32383419 T/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs2692947 0.683 rs62153700 chr2:96581338 C/T cg22654517 chr2:96458247 NA 0.36 6.43 0.33 4.29e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg06697600 chr4:7070879 GRPEL1 -0.38 -5.8 -0.3 1.52e-8 Monocyte percentage of white cells; LUSC cis rs2692947 0.655 rs2315668 chr2:96429562 T/C cg22654517 chr2:96458247 NA 0.37 6.89 0.35 2.85e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs877282 0.945 rs11253397 chr10:789774 A/G cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs7267979 0.966 rs6107031 chr20:25350677 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.34 -0.74 2.17e-60 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11098499 0.863 rs3822192 chr4:120445720 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.3 0.33 9.18e-10 Corneal astigmatism; LUSC cis rs2324229 0.828 rs1180200 chr6:83958340 A/C cg08257003 chr6:84140564 ME1 0.29 6.84 0.35 3.69e-11 Platelet-derived growth factor BB levels; LUSC trans rs61931739 0.517 rs1586409 chr12:34046614 C/A cg26384229 chr12:38710491 ALG10B 0.7 10.84 0.51 1.21e-23 Morning vs. evening chronotype; LUSC cis rs7091068 0.671 rs604489 chr10:95405408 T/C cg20715218 chr10:95462985 C10orf4 -0.61 -7.16 -0.36 5.32e-12 Urinary tract infection frequency; LUSC cis rs79349575 0.715 rs999474 chr17:46987665 G/A cg22482690 chr17:47019901 SNF8 -0.34 -6.12 -0.32 2.56e-9 Type 2 diabetes; LUSC cis rs9925964 0.933 rs56314408 chr16:31117389 T/C cg03418659 chr16:31128414 MYST1 -0.39 -6.14 -0.32 2.3e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12208915 0.848 rs12203336 chr6:79518315 G/T cg05283184 chr6:79620031 NA 0.42 5.68 0.3 2.92e-8 Left atrial antero-posterior diameter; LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg10518543 chr12:38710700 ALG10B -0.41 -5.65 -0.3 3.36e-8 Morning vs. evening chronotype; LUSC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg14541582 chr5:601475 NA -0.38 -6.0 -0.31 5.23e-9 Lung disease severity in cystic fibrosis; LUSC cis rs6977660 0.660 rs7357202 chr7:19817911 T/A cg07541023 chr7:19748670 TWISTNB 0.6 6.51 0.34 2.7e-10 Thyroid stimulating hormone; LUSC cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg24558204 chr6:135376177 HBS1L -0.66 -10.35 -0.49 6.06e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg04287289 chr16:89883240 FANCA 0.6 8.66 0.43 1.98e-16 Vitiligo; LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg17968037 chr7:100024898 ZCWPW1 -0.4 -5.71 -0.3 2.53e-8 Platelet count; LUSC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg05802129 chr4:122689817 NA -0.46 -7.7 -0.39 1.53e-13 Type 2 diabetes; LUSC cis rs5769765 0.773 rs138861 chr22:50202276 A/G cg08270630 chr22:50330655 NA -0.38 -5.74 -0.3 2.09e-8 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16123774 chr13:52733565 NEK3 -0.41 -6.01 -0.31 4.86e-9 Electrocardiographic conduction measures; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18099408 chr3:52552593 STAB1 0.37 6.57 0.34 1.91e-10 Bipolar disorder; LUSC trans rs4596713 0.568 rs6560585 chr9:71747395 A/G cg25283916 chr1:242222868 NA -0.31 -6.48 -0.33 3.23e-10 Headache; LUSC cis rs6460942 0.591 rs7804805 chr7:12332066 C/G cg06484146 chr7:12443880 VWDE -0.57 -5.98 -0.31 5.79e-9 Coronary artery disease; LUSC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg16060761 chr17:80687452 NA 0.57 10.88 0.51 8.58e-24 Glycated hemoglobin levels; LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg08470875 chr2:26401718 FAM59B -0.69 -9.06 -0.44 1.1e-17 Gut microbiome composition (summer); LUSC cis rs8114671 0.562 rs4911450 chr20:33512406 C/T cg24642439 chr20:33292090 TP53INP2 0.45 6.48 0.33 3.38e-10 Height; LUSC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg00310523 chr12:86230176 RASSF9 0.51 9.68 0.47 1.07e-19 Major depressive disorder; LUSC cis rs7100689 0.646 rs9804233 chr10:82134667 T/C cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg26528668 chr16:1614120 IFT140 0.45 7.5 0.38 5.74e-13 Coronary artery disease; LUSC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg04455712 chr21:45112962 RRP1B 0.48 9.18 0.45 4.58e-18 Mean corpuscular volume; LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.45 -5.75 -0.3 1.99e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg26384229 chr12:38710491 ALG10B 0.9 15.19 0.64 5.67e-40 Bladder cancer; LUSC cis rs7607369 0.536 rs6436090 chr2:219669002 A/G cg02176678 chr2:219576539 TTLL4 -0.51 -8.94 -0.44 2.63e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7824557 0.628 rs7831346 chr8:11193530 C/T cg21775007 chr8:11205619 TDH 0.79 13.48 0.59 2.26e-33 Retinal vascular caliber; LUSC cis rs11229555 0.598 rs11229426 chr11:58180063 T/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10203711 0.789 rs6431616 chr2:239540279 A/G cg14580085 chr2:239553406 NA 0.35 5.78 0.3 1.69e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg18357526 chr6:26021779 HIST1H4A 0.41 6.08 0.32 3.29e-9 Intelligence (multi-trait analysis); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg27057602 chr19:49403306 TULP2;NUCB1 0.38 6.04 0.31 4.19e-9 Schizophrenia; LUSC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.53 -8.03 -0.4 1.65e-14 Axial length; LUSC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg18252515 chr7:66147081 NA -1.24 -8.45 -0.42 9.39e-16 Diabetic kidney disease; LUSC cis rs9303401 0.659 rs17822735 chr17:56620167 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.88 13.71 0.6 2.89e-34 Cognitive test performance; LUSC cis rs3812049 0.826 rs2409110 chr5:127433047 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 9.13 0.45 6.54e-18 Lymphocyte counts;Red cell distribution width; LUSC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg14433983 chr11:636460 DRD4 -0.37 -6.01 -0.31 4.77e-9 Systemic lupus erythematosus; LUSC trans rs8072100 0.701 rs8075566 chr17:45771037 G/A cg04995722 chr7:26192034 NFE2L3 -0.41 -6.4 -0.33 5.19e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10089 1.000 rs10060390 chr5:127452947 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.79 0.54 4.59e-27 Ileal carcinoids; LUSC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg27572855 chr1:25598939 RHD 0.41 7.15 0.36 5.55e-12 Erythrocyte sedimentation rate; LUSC trans rs2797160 1.000 rs2211418 chr6:125995503 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.39 -0.33 5.5e-10 Endometrial cancer; LUSC trans rs7937682 1.000 rs12363179 chr11:111568091 G/A cg18187862 chr3:45730750 SACM1L -0.55 -6.78 -0.35 5.52e-11 Primary sclerosing cholangitis; LUSC cis rs61931739 0.500 rs11053177 chr12:34412829 G/A cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC trans rs9329221 0.537 rs6995859 chr8:9975709 T/A cg06636001 chr8:8085503 FLJ10661 0.47 6.87 0.35 3.08e-11 Neuroticism; LUSC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg23711669 chr6:146136114 FBXO30 0.83 15.42 0.64 6.99e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg13685833 chr1:53393034 SCP2 -0.4 -5.98 -0.31 5.82e-9 Monocyte count; LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg11645453 chr3:52864694 ITIH4 0.36 8.3 0.41 2.64e-15 Bipolar disorder; LUSC cis rs422421 0.729 rs387598 chr5:176517170 C/T cg00618323 chr5:176515533 FGFR4 0.32 5.65 0.3 3.44e-8 Height; LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg10729496 chr3:10149963 C3orf24 0.56 7.62 0.38 2.62e-13 Alzheimer's disease; LUSC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg18402987 chr7:1209562 NA 0.63 7.58 0.38 3.48e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9650657 0.655 rs10093774 chr8:10703293 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.53 0.34 2.52e-10 Neuroticism; LUSC cis rs6665290 0.901 rs7535826 chr1:227213968 A/C cg10327440 chr1:227177885 CDC42BPA 1.19 39.53 0.91 5.26e-128 Myeloid white cell count; LUSC cis rs6696846 0.905 rs11240349 chr1:205041015 G/A cg03948781 chr1:205179583 DSTYK 0.31 5.86 0.31 1.08e-8 Red blood cell count; LUSC cis rs6484504 0.576 rs208103 chr11:31167400 A/G cg26647111 chr11:31128758 NA -0.41 -6.01 -0.31 4.93e-9 Red blood cell count; LUSC cis rs2479106 0.553 rs3739827 chr9:126690157 A/G cg16191174 chr9:126692580 DENND1A -0.49 -6.17 -0.32 1.93e-9 Polycystic ovary syndrome; LUSC cis rs9902453 1.000 rs4075623 chr17:28386526 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC cis rs757278 0.591 rs34331324 chr7:117300188 A/C cg10524701 chr7:117356490 CTTNBP2 0.4 5.74 0.3 2.08e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg07677032 chr17:61819896 STRADA 0.55 9.09 0.45 9.21e-18 Prudent dietary pattern; LUSC trans rs11098499 0.909 rs7681214 chr4:120385320 C/A cg25214090 chr10:38739885 LOC399744 0.58 8.45 0.42 9.1e-16 Corneal astigmatism; LUSC cis rs6543140 0.964 rs2310301 chr2:103072935 C/T cg09003973 chr2:102972529 NA 0.54 7.02 0.36 1.25e-11 Blood protein levels; LUSC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg01416388 chr22:39784598 NA -0.41 -6.76 -0.35 6.18e-11 Intelligence (multi-trait analysis); LUSC cis rs7804356 1.000 rs10267950 chr7:26826757 T/A cg03456212 chr7:26904342 SKAP2 -0.56 -6.63 -0.34 1.36e-10 Type 1 diabetes; LUSC cis rs1670533 1.000 rs28562028 chr4:1055115 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC cis rs3733585 0.682 rs13124563 chr4:9927553 A/G cg11266682 chr4:10021025 SLC2A9 0.49 9.05 0.44 1.17e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg16405210 chr4:1374714 KIAA1530 -0.45 -6.64 -0.34 1.29e-10 Obesity-related traits; LUSC trans rs656319 0.669 rs56279061 chr8:9873980 T/C cg15556689 chr8:8085844 FLJ10661 -0.48 -6.93 -0.35 2.22e-11 Myopia (pathological); LUSC cis rs981844 0.775 rs17299211 chr4:154738284 G/A cg14289246 chr4:154710475 SFRP2 0.46 6.22 0.32 1.5e-9 Response to statins (LDL cholesterol change); LUSC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg04800585 chr6:26043546 HIST1H2BB 0.4 5.86 0.31 1.13e-8 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.863 rs10034450 chr4:120455649 A/G cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg23260525 chr10:116636907 FAM160B1 0.47 10.26 0.49 1.19e-21 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs61931739 0.892 rs61931711 chr12:34045374 C/T cg13010199 chr12:38710504 ALG10B -0.4 -6.01 -0.31 4.99e-9 Morning vs. evening chronotype; LUSC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg02891314 chr5:179741120 GFPT2 -0.63 -10.19 -0.49 2.12e-21 Height; LUSC trans rs3733585 0.648 rs7378305 chr4:9954893 C/T cg26043149 chr18:55253948 FECH -0.45 -7.02 -0.36 1.27e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg11742103 chr11:62369870 EML3;MTA2 0.57 9.17 0.45 4.99e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34779708 0.931 rs1926554 chr10:35344969 C/T cg03585969 chr10:35415529 CREM 0.58 8.43 0.42 1.02e-15 Inflammatory bowel disease;Crohn's disease; LUSC trans rs3733585 0.699 rs6834893 chr4:9959123 C/T cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg06544989 chr22:39130855 UNC84B 0.33 5.67 0.3 3.02e-8 Menopause (age at onset); LUSC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg17178900 chr1:205818956 PM20D1 0.51 8.07 0.4 1.29e-14 Menarche (age at onset); LUSC cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg00290607 chr11:67383545 NA 0.36 6.71 0.34 8.33e-11 Mean corpuscular volume; LUSC cis rs599083 0.530 rs689179 chr11:68179166 A/G cg01657329 chr11:68192670 LRP5 0.48 6.32 0.33 8.42e-10 Bone mineral density (spine); LUSC cis rs12541635 0.833 rs4099936 chr8:107099297 G/A cg10147462 chr8:107024639 NA -0.45 -7.78 -0.39 8.87e-14 Age of smoking initiation; LUSC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg04398451 chr17:18023971 MYO15A 0.43 6.72 0.35 7.88e-11 Total body bone mineral density; LUSC cis rs2677744 1.000 rs1266483 chr15:91462406 A/G cg00526711 chr15:91477898 UNC45A 0.3 6.1 0.32 2.95e-9 Attention deficit hyperactivity disorder; LUSC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg11812906 chr14:75593930 NEK9 0.67 11.71 0.54 8.78e-27 Height; LUSC cis rs2354432 0.556 rs885305 chr1:146786080 G/A cg25205988 chr1:146714368 CHD1L -1.02 -9.56 -0.46 2.63e-19 Mitochondrial DNA levels; LUSC cis rs9398803 0.865 rs9372839 chr6:126809870 G/A cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.88e-9 Male-pattern baldness; LUSC cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg17097710 chr5:1061055 SLC12A7 -0.4 -6.2 -0.32 1.65e-9 QT interval; LUSC cis rs16917546 1.000 rs12768538 chr10:64406358 C/G cg03961010 chr10:64397487 ZNF365 0.41 6.53 0.34 2.44e-10 Basal cell carcinoma; LUSC cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg22782873 chr19:19639568 YJEFN3 0.46 5.65 0.3 3.45e-8 Bipolar disorder; LUSC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 12.03 0.55 6.09e-28 Personality dimensions; LUSC trans rs7937682 0.824 rs539524 chr11:111477325 A/G cg18187862 chr3:45730750 SACM1L 0.52 6.84 0.35 3.74e-11 Primary sclerosing cholangitis; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg09033563 chr22:24373618 LOC391322 -0.49 -6.81 -0.35 4.54e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1559088 1.000 rs1559087 chr19:33551041 A/G cg17764715 chr19:33622953 WDR88 0.58 7.86 0.4 5.25e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.74 -0.3 2.15e-8 Tonsillectomy; LUSC cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg01884057 chr2:25150051 NA 0.48 11.43 0.53 9.67e-26 Body mass index; LUSC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg03732007 chr1:2071316 PRKCZ -0.5 -8.73 -0.43 1.23e-16 Height; LUSC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC cis rs4664308 0.618 rs17830755 chr2:160888835 T/C cg03641300 chr2:160917029 PLA2R1 -0.49 -7.97 -0.4 2.59e-14 Idiopathic membranous nephropathy; LUSC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg22535103 chr8:58192502 C8orf71 -0.79 -9.6 -0.46 2.04e-19 Developmental language disorder (linguistic errors); LUSC trans rs9929218 0.953 rs12930910 chr16:68762520 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -12.46 -0.56 1.52e-29 Colorectal cancer; LUSC cis rs10465746 0.725 rs2024591 chr1:84329235 C/T cg10977910 chr1:84465055 TTLL7 0.52 7.26 0.37 2.77e-12 Obesity-related traits; LUSC cis rs6121246 0.567 rs6060262 chr20:30193071 A/C cg18721089 chr20:30220636 NA -0.41 -6.57 -0.34 1.93e-10 Mean corpuscular hemoglobin; LUSC cis rs713477 1.000 rs10134905 chr14:55911792 G/A cg13175173 chr14:55914753 NA -0.32 -6.68 -0.34 9.96e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg16339924 chr4:17578868 LAP3 0.6 9.22 0.45 3.39e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6942756 1.000 rs73472312 chr7:128925217 T/C cg02491457 chr7:128862824 NA -0.5 -6.91 -0.35 2.52e-11 White matter hyperintensity burden; LUSC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg12560992 chr17:57184187 TRIM37 -0.85 -15.51 -0.65 2.95e-41 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.680 rs16921675 chr8:58052082 A/G cg21724239 chr8:58056113 NA 0.53 6.49 0.33 3.17e-10 Developmental language disorder (linguistic errors); LUSC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg10792982 chr14:105748885 BRF1 0.5 8.85 0.44 5.37e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs11229555 0.574 rs66573492 chr11:58183797 G/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7177699 0.557 rs12442476 chr15:79117856 G/A cg00540400 chr15:79124168 NA 0.46 8.1 0.41 1.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4332037 0.707 rs4721096 chr7:1877311 T/C cg12432903 chr7:1882776 MAD1L1 -0.49 -5.97 -0.31 5.98e-9 Bipolar disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24771266 chr19:44576270 ZNF284 -0.4 -5.95 -0.31 6.73e-9 Electrocardiographic conduction measures; LUSC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.05 0.31 3.81e-9 Schizophrenia; LUSC trans rs2235573 0.517 rs4821727 chr22:38393423 C/A cg19894588 chr14:64061835 NA 0.44 6.45 0.33 3.95e-10 Glioblastoma;Glioma; LUSC cis rs412000 0.507 rs2680688 chr17:56450524 T/C cg05425664 chr17:57184151 TRIM37 0.39 5.82 0.3 1.4e-8 Primary tooth development (time to first tooth eruption); LUSC trans rs7980799 0.716 rs1351683 chr12:33598563 G/A cg26384229 chr12:38710491 ALG10B -0.59 -8.94 -0.44 2.71e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs13287066 0.651 rs10992716 chr9:96134897 C/T cg13717394 chr9:96054313 WNK2 -0.39 -6.68 -0.34 1.03e-10 Intelligence (multi-trait analysis); LUSC cis rs7119038 0.818 rs11217042 chr11:118682528 G/A cg19308663 chr11:118741387 NA 0.34 6.06 0.31 3.73e-9 Sjögren's syndrome; LUSC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg15556689 chr8:8085844 FLJ10661 0.68 10.87 0.51 9.21e-24 Mood instability; LUSC trans rs61931739 0.534 rs10844828 chr12:34303109 C/T cg13010199 chr12:38710504 ALG10B 0.46 7.15 0.36 5.45e-12 Morning vs. evening chronotype; LUSC cis rs73206853 0.841 rs17625767 chr12:111102627 A/C cg12870014 chr12:110450643 ANKRD13A 0.7 6.48 0.33 3.23e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1153858 0.723 rs11855527 chr15:45606685 G/A cg26924012 chr15:45694286 SPATA5L1 -1.11 -18.27 -0.71 3.32e-52 Homoarginine levels; LUSC cis rs2235649 0.833 rs4335769 chr16:1849376 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.02 -0.31 4.6e-9 Blood metabolite levels; LUSC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.34 -6.53 -0.34 2.45e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs11098499 0.697 rs10020027 chr4:120381879 G/C cg25214090 chr10:38739885 LOC399744 0.54 8.02 0.4 1.78e-14 Corneal astigmatism; LUSC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.91 0.51 6.82e-24 Hip circumference adjusted for BMI; LUSC cis rs6121246 0.529 rs6060291 chr20:30198043 T/G cg21427119 chr20:30132790 HM13 -0.44 -6.32 -0.33 8.34e-10 Mean corpuscular hemoglobin; LUSC cis rs4899554 0.640 rs72719935 chr14:75724345 C/T cg18117039 chr14:75741733 NA 0.55 7.29 0.37 2.32e-12 Inflammatory bowel disease; LUSC cis rs2279817 0.863 rs11203441 chr1:18026725 C/T cg21791023 chr1:18019539 ARHGEF10L 0.47 6.79 0.35 5.08e-11 Neuroticism; LUSC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg27121462 chr16:89883253 FANCA 0.54 8.45 0.42 9e-16 Vitiligo; LUSC cis rs6901250 0.587 rs339357 chr6:117198291 G/C cg12892004 chr6:117198278 RFX6 -0.44 -8.12 -0.41 9e-15 C-reactive protein levels; LUSC cis rs13242816 1.000 rs6979182 chr7:116119345 T/G cg16553024 chr7:116138462 CAV2 -0.52 -5.68 -0.3 2.89e-8 P wave duration; LUSC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.53 -0.38 4.67e-13 Aortic root size; LUSC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg04727924 chr7:799746 HEATR2 -0.56 -6.65 -0.34 1.2e-10 Cerebrospinal P-tau181p levels; LUSC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg24531977 chr5:56204891 C5orf35 -0.59 -8.69 -0.43 1.59e-16 Coronary artery disease; LUSC cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg21643547 chr1:205240462 TMCC2 -0.53 -10.11 -0.48 3.82e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs3931020 0.720 rs927904 chr1:75260328 A/G cg10128416 chr1:75198403 TYW3;CRYZ 0.46 5.7 0.3 2.58e-8 Resistin levels; LUSC cis rs7582720 1.000 rs72926793 chr2:203826396 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg02772935 chr3:125709198 NA -0.48 -5.82 -0.3 1.36e-8 Blood pressure (smoking interaction); LUSC cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg06784218 chr1:46089804 CCDC17 0.53 11.03 0.52 2.54e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2857891 0.650 rs2857928 chr11:6989721 C/G cg04053776 chr11:6947353 ZNF215 -0.42 -6.14 -0.32 2.39e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg22676075 chr6:135203613 NA 0.58 9.1 0.45 8.57e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs1005277 0.557 rs2983338 chr10:38550734 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.21 -0.45 3.6e-18 Extrinsic epigenetic age acceleration; LUSC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg14298792 chr15:30685198 CHRFAM7A -0.48 -5.72 -0.3 2.39e-8 Huntington's disease progression; LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC cis rs6594499 0.872 rs10038177 chr5:110436450 C/T cg04022379 chr5:110408740 TSLP 0.45 6.82 0.35 4.3e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11785693 0.862 rs6990234 chr8:4996812 A/G cg26367366 chr8:4980734 NA 0.71 8.4 0.42 1.33e-15 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs76793172 1.000 rs56006974 chr19:46330636 C/A cg27118825 chr19:46318748 RSPH6A;SYMPK 0.46 5.69 0.3 2.75e-8 Eosinophil counts; LUSC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg16928487 chr17:17741425 SREBF1 0.47 9.28 0.45 2.25e-18 Total body bone mineral density; LUSC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg24154853 chr7:158122151 PTPRN2 0.45 8.74 0.43 1.19e-16 Calcium levels; LUSC cis rs72781680 0.821 rs72790329 chr2:24129277 A/G cg08917208 chr2:24149416 ATAD2B 0.59 6.79 0.35 5.04e-11 Lymphocyte counts; LUSC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.06 -0.31 3.7e-9 Developmental language disorder (linguistic errors); LUSC cis rs7712401 0.720 rs10075963 chr5:122185421 T/A cg19077854 chr5:122220652 SNX24 0.32 7.29 0.37 2.32e-12 Mean platelet volume; LUSC cis rs9420 0.528 rs7102271 chr11:57396825 G/T cg23127183 chr11:57508653 C11orf31 -0.45 -6.32 -0.33 8.19e-10 Schizophrenia; LUSC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg05585544 chr11:47624801 NA -0.42 -7.34 -0.37 1.62e-12 Subjective well-being; LUSC cis rs793571 0.536 rs7183336 chr15:58966236 C/T cg05156742 chr15:59063176 FAM63B 0.56 7.62 0.38 2.62e-13 Schizophrenia; LUSC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg06618935 chr21:46677482 NA -0.42 -8.59 -0.43 3.44e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7289126 1.000 rs8142686 chr22:38634266 C/T cg25457927 chr22:38595422 NA -0.31 -6.05 -0.31 3.95e-9 Mammographic density (dense area);Percent mammographic density; LUSC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg20607287 chr7:12443886 VWDE -0.61 -6.34 -0.33 7.27e-10 Coronary artery disease; LUSC cis rs1577917 0.958 rs7747897 chr6:86647349 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC cis rs1775715 0.811 rs1775741 chr10:32267284 C/T cg03015672 chr10:32216066 ARHGAP12 -0.33 -5.81 -0.3 1.44e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2841277 0.676 rs10438247 chr14:105411781 G/A cg15352829 chr14:105391018 PLD4 -0.39 -8.1 -0.41 1.03e-14 Rheumatoid arthritis; LUSC cis rs4319547 0.955 rs6489159 chr12:123112806 G/A cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.37 -0.42 1.64e-15 Body mass index; LUSC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg04362960 chr10:104952993 NT5C2 0.54 8.07 0.4 1.26e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9462027 0.628 rs9296131 chr6:34776361 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.68 -0.3 3e-8 Systemic lupus erythematosus; LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.06 0.36 9.75e-12 Bipolar disorder; LUSC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg25427524 chr10:38739819 LOC399744 -0.74 -14.06 -0.61 1.38e-35 Extrinsic epigenetic age acceleration; LUSC cis rs9837602 1.000 rs9864437 chr3:99764754 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.18 0.32 1.82e-9 Breast cancer; LUSC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg22535103 chr8:58192502 C8orf71 -0.58 -6.83 -0.35 4.1e-11 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg17376030 chr22:41985996 PMM1 -0.47 -5.84 -0.3 1.25e-8 Vitiligo; LUSC trans rs890100 0.902 rs13421558 chr2:56736073 A/T cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.31 -5.99 -0.31 5.5e-9 Gut microbiome composition (summer); LUSC cis rs7584330 0.910 rs7606177 chr2:238394913 G/C cg14458575 chr2:238380390 NA 0.64 11.2 0.52 6.32e-25 Prostate cancer; LUSC cis rs6500395 0.928 rs7199206 chr16:48702538 A/G cg04672837 chr16:48644449 N4BP1 -0.48 -7.15 -0.36 5.48e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11190604 1.000 rs7088512 chr10:102303498 G/T cg16342193 chr10:102329863 NA -0.33 -5.97 -0.31 6.01e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg22920501 chr2:26401640 FAM59B -0.72 -10.01 -0.48 8.2e-21 Gut microbiome composition (summer); LUSC cis rs1670533 0.685 rs56019586 chr4:1059842 C/G cg16405210 chr4:1374714 KIAA1530 -0.48 -5.85 -0.3 1.2e-8 Recombination rate (females); LUSC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg19622623 chr12:86230825 RASSF9 -0.44 -6.28 -0.32 1.08e-9 Major depressive disorder; LUSC cis rs6570726 0.935 rs386344 chr6:145855622 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.28 0.59 1.28e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.69 -0.39 1.66e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs3020736 0.500 rs6519306 chr22:42501217 T/C cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs250677 1.000 rs36080 chr5:148430451 A/G cg18129178 chr5:148520854 ABLIM3 -0.68 -10.92 -0.51 6.2e-24 Breast cancer; LUSC cis rs9487051 0.704 rs1741930 chr6:109519797 T/A cg01475377 chr6:109611718 NA -0.36 -6.11 -0.32 2.7e-9 Reticulocyte fraction of red cells; LUSC cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs7100689 0.622 rs10887798 chr10:82131613 G/A cg01528321 chr10:82214614 TSPAN14 0.85 12.99 0.58 1.65e-31 Post bronchodilator FEV1; LUSC cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg23711669 chr6:146136114 FBXO30 0.88 16.19 0.66 6.45e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.725 rs11570094 chr11:47359706 A/C cg20135002 chr11:47629003 NA 0.42 5.95 0.31 6.7e-9 Subjective well-being; LUSC cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg24642439 chr20:33292090 TP53INP2 0.63 9.97 0.48 1.11e-20 Coronary artery disease; LUSC cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg18876405 chr7:65276391 NA 0.46 7.15 0.36 5.67e-12 Aortic root size; LUSC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg25427524 chr10:38739819 LOC399744 -0.65 -11.61 -0.54 2.12e-26 Extrinsic epigenetic age acceleration; LUSC cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg04455712 chr21:45112962 RRP1B 0.46 8.84 0.44 5.51e-17 Mean corpuscular volume; LUSC cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.63 0.47 1.62e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3784262 0.528 rs4553566 chr15:58336319 T/C cg12031962 chr15:58353849 ALDH1A2 -0.31 -5.65 -0.3 3.44e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7851660 0.874 rs7860144 chr9:100626884 A/G cg13688889 chr9:100608707 NA -0.57 -8.98 -0.44 1.98e-17 Strep throat; LUSC cis rs9527 0.590 rs3861984 chr10:104916980 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.46 -0.33 3.69e-10 Arsenic metabolism; LUSC cis rs62400317 0.701 rs12194924 chr6:44961513 T/C cg20913747 chr6:44695427 NA -0.45 -7.06 -0.36 9.49e-12 Total body bone mineral density; LUSC trans rs61931739 0.517 rs10844727 chr12:34017435 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.87 0.51 9.05e-24 Morning vs. evening chronotype; LUSC cis rs73200209 0.744 rs17498893 chr12:116674831 G/C cg01776926 chr12:116560359 MED13L -0.49 -5.98 -0.31 5.8e-9 Total body bone mineral density; LUSC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg13390004 chr1:15929781 NA -0.38 -6.34 -0.33 7.51e-10 Systolic blood pressure; LUSC cis rs1048238 0.506 rs848194 chr1:16285342 G/A cg22431228 chr1:16359049 CLCNKA 0.43 8.47 0.42 8.12e-16 Systolic blood pressure; LUSC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg21724239 chr8:58056113 NA 0.6 7.07 0.36 9.38e-12 Developmental language disorder (linguistic errors); LUSC cis rs12310956 0.510 rs10743832 chr12:33884146 A/C cg06521331 chr12:34319734 NA -0.36 -5.86 -0.31 1.14e-8 Morning vs. evening chronotype; LUSC cis rs7945705 0.875 rs11042059 chr11:8795080 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.54 10.48 0.5 2.11e-22 Hemoglobin concentration; LUSC trans rs61931739 0.817 rs10772144 chr12:34242463 A/C cg26384229 chr12:38710491 ALG10B 0.54 8.63 0.43 2.46e-16 Morning vs. evening chronotype; LUSC cis rs2204008 0.777 rs8189597 chr12:38307739 G/C cg13010199 chr12:38710504 ALG10B -0.69 -10.65 -0.5 5.57e-23 Bladder cancer; LUSC trans rs61931739 0.817 rs2203086 chr12:34232590 T/C cg24313572 chr1:56050060 NA -0.31 -6.43 -0.33 4.53e-10 Morning vs. evening chronotype; LUSC cis rs6500395 1.000 rs55671623 chr16:48631154 A/G cg04672837 chr16:48644449 N4BP1 0.5 7.48 0.38 6.47e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1322512 1.000 rs1631457 chr6:152946514 C/T cg27316956 chr6:152958899 SYNE1 -0.33 -5.65 -0.3 3.45e-8 Tonometry; LUSC cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg11584989 chr19:19387371 SF4 0.57 6.78 0.35 5.44e-11 Bipolar disorder; LUSC cis rs4595586 0.505 rs12827467 chr12:39374014 A/G cg26384229 chr12:38710491 ALG10B 0.49 6.99 0.36 1.51e-11 Morning vs. evening chronotype; LUSC cis rs2795502 1.000 rs3121279 chr10:43378449 T/A cg20628663 chr10:43360327 NA 0.64 9.49 0.46 4.44e-19 Blood protein levels; LUSC cis rs73416724 1.000 rs41281798 chr6:43325787 C/A cg26312998 chr6:43337775 ZNF318 0.57 6.66 0.34 1.16e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs6580649 0.941 rs72644847 chr12:48516093 C/A cg24011408 chr12:48396354 COL2A1 -0.54 -7.01 -0.36 1.36e-11 Lung cancer; LUSC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg20476274 chr7:133979776 SLC35B4 0.86 16.22 0.66 4.67e-44 Mean platelet volume; LUSC cis rs11997175 0.646 rs12678266 chr8:33689254 A/G ch.8.33884649F chr8:33765107 NA 0.48 7.11 0.36 7.29e-12 Body mass index; LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg22920501 chr2:26401640 FAM59B 0.82 11.99 0.55 8.49e-28 Gut microbiome composition (summer); LUSC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg18681998 chr4:17616180 MED28 0.77 13.73 0.6 2.54e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4728302 0.583 rs58955798 chr7:133158420 C/T cg10665199 chr7:133106180 EXOC4 0.58 8.16 0.41 6.67e-15 Intelligence;Intelligence (multi-trait analysis); LUSC trans rs34421088 0.560 rs1478898 chr8:11395079 G/A cg06636001 chr8:8085503 FLJ10661 -0.59 -9.13 -0.45 6.48e-18 Neuroticism; LUSC cis rs3820928 0.605 rs6718767 chr2:227800776 A/G cg11843606 chr2:227700838 RHBDD1 -0.65 -10.42 -0.5 3.44e-22 Pulmonary function; LUSC cis rs3018712 0.532 rs2510399 chr11:68421458 A/G cg22747802 chr11:68417633 NA -0.45 -6.18 -0.32 1.91e-9 Total body bone mineral density; LUSC cis rs10028773 0.556 rs4473640 chr4:120260437 G/A cg24375607 chr4:120327624 NA 0.71 11.34 0.53 1.94e-25 Educational attainment; LUSC cis rs7705502 1.000 rs10516107 chr5:173348156 G/A cg18693985 chr5:173351052 CPEB4 -0.36 -5.72 -0.3 2.39e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs78707713 0.560 rs61848398 chr10:71226103 G/A cg12610070 chr10:71211762 TSPAN15 -0.49 -9.28 -0.45 2.13e-18 Venous thromboembolism; LUSC cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg06784218 chr1:46089804 CCDC17 -0.46 -8.86 -0.44 4.7e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs877282 0.838 rs11253408 chr10:796374 T/C cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg21535247 chr6:8435926 SLC35B3 0.58 9.01 0.44 1.59e-17 Motion sickness; LUSC cis rs17270561 1.000 rs12200962 chr6:25828986 T/C cg17691542 chr6:26056736 HIST1H1C 0.76 9.72 0.47 8.07e-20 Iron status biomarkers; LUSC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.87 -0.81 5.11e-78 Height; LUSC trans rs9291683 0.679 rs13137795 chr4:10051506 G/A cg26043149 chr18:55253948 FECH 0.49 7.14 0.36 5.76e-12 Bone mineral density; LUSC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg24397884 chr7:158709396 WDR60 0.62 9.58 0.46 2.38e-19 Height; LUSC cis rs1003719 0.645 rs8131944 chr21:38547215 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg11344533 chr11:111475393 SIK2 0.48 6.34 0.33 7.31e-10 Primary sclerosing cholangitis; LUSC cis rs7336332 0.662 rs9581862 chr13:28039993 T/G cg22138327 chr13:27999177 GTF3A 0.7 9.5 0.46 4.1e-19 Weight; LUSC cis rs11190604 1.000 rs2495753 chr10:102325640 C/T cg16342193 chr10:102329863 NA -0.4 -6.51 -0.34 2.75e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg01745370 chr2:109065127 GCC2 0.52 9.17 0.45 4.98e-18 Mean platelet volume; LUSC cis rs929354 1.000 rs1182413 chr7:157058557 G/A cg17757837 chr7:157058334 UBE3C -0.92 -15.44 -0.65 5.63e-41 Body mass index; LUSC cis rs12579753 0.871 rs10862363 chr12:82201254 T/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.88 -0.44 4.14e-17 Autism spectrum disorder or schizophrenia; LUSC cis rs859767 0.501 rs71348712 chr2:135391590 T/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.61 -0.34 1.55e-10 Neuroticism; LUSC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.46 7.89 0.4 4.26e-14 Breast cancer; LUSC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7827545 1.000 rs7463007 chr8:135567143 C/T cg17885191 chr8:135476712 NA 0.57 8.58 0.43 3.61e-16 Hypertension (SNP x SNP interaction); LUSC cis rs6500602 0.893 rs934888 chr16:4462832 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.03 0.36 1.19e-11 Schizophrenia; LUSC cis rs9788682 0.747 rs2568497 chr15:78721397 G/T cg24631222 chr15:78858424 CHRNA5 -0.66 -8.68 -0.43 1.79e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs12317459 0.591 rs10778913 chr12:83202336 C/G cg10237817 chr1:154519846 TDRD10 0.31 6.23 0.32 1.43e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.03 -0.36 1.17e-11 Colorectal cancer; LUSC cis rs7843479 0.601 rs2306645 chr8:21845428 C/T cg17168535 chr8:21777572 XPO7 -0.8 -14.19 -0.61 4.19e-36 Mean corpuscular volume; LUSC cis rs2540226 0.844 rs1035138 chr2:39999341 G/A cg23576258 chr2:39999331 THUMPD2 0.34 5.73 0.3 2.24e-8 Personality dimensions; LUSC cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.64e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg13531842 chr10:38383804 ZNF37A -0.48 -7.42 -0.38 9.51e-13 Extrinsic epigenetic age acceleration; LUSC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg06108461 chr20:60628389 TAF4 0.75 12.42 0.56 2.24e-29 Body mass index; LUSC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.98 15.5 0.65 3.28e-41 Platelet count; LUSC cis rs950169 0.810 rs2879976 chr15:85109578 G/A cg12863693 chr15:85201151 NMB 0.35 7.14 0.36 6e-12 Schizophrenia; LUSC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -6.03 -0.31 4.27e-9 Total body bone mineral density; LUSC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg13206674 chr6:150067644 NUP43 0.6 9.53 0.46 3.38e-19 Lung cancer; LUSC cis rs9527 0.545 rs12247514 chr10:104958066 C/A cg23093090 chr10:104574429 C10orf26 -0.34 -6.26 -0.32 1.21e-9 Arsenic metabolism; LUSC cis rs6445797 0.632 rs11921326 chr3:56664322 C/A cg13792233 chr3:56591045 CCDC66 0.41 5.72 0.3 2.33e-8 Gastritis; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg00431813 chr7:1051703 C7orf50 -0.38 -5.86 -0.31 1.13e-8 Longevity;Endometriosis; LUSC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 9.29 0.45 2.08e-18 Mean platelet volume; LUSC cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs9560113 0.922 rs4773377 chr13:112174152 G/C cg14154082 chr13:112174009 NA 0.38 7.95 0.4 2.97e-14 Menarche (age at onset); LUSC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg05347473 chr6:146136440 FBXO30 0.65 11.4 0.53 1.16e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs244293 1.000 rs2628314 chr17:53235182 T/C cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.84 -0.3 1.23e-8 Menarche (age at onset); LUSC cis rs6733011 0.500 rs7560696 chr2:99405800 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.44 -0.33 4.23e-10 Bipolar disorder; LUSC cis rs11098499 0.738 rs28408407 chr4:120376030 C/G cg09307838 chr4:120376055 NA 0.77 11.38 0.53 1.43e-25 Corneal astigmatism; LUSC cis rs1577917 0.958 rs12199832 chr6:86652748 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.65 -0.34 1.21e-10 Response to antipsychotic treatment; LUSC cis rs6062509 0.929 rs55791529 chr20:62363858 C/T cg21849932 chr20:62369462 LIME1 -0.4 -5.91 -0.31 8.37e-9 Prostate cancer; LUSC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg02772935 chr3:125709198 NA -0.49 -5.89 -0.31 9.62e-9 Blood pressure (smoking interaction); LUSC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg13647721 chr17:30228624 UTP6 0.61 6.44 0.33 4.27e-10 Hip circumference adjusted for BMI; LUSC cis rs6901250 1.000 rs6924002 chr6:117114223 A/T cg12892004 chr6:117198278 RFX6 0.4 7.22 0.37 3.53e-12 C-reactive protein levels; LUSC cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg23711669 chr6:146136114 FBXO30 -0.83 -14.97 -0.63 3.94e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg04315214 chr1:2043799 PRKCZ 0.38 7.83 0.39 6.42e-14 Height; LUSC cis rs7215564 0.818 rs1531946 chr17:78630807 G/A cg23238734 chr17:78661607 RPTOR 0.48 5.89 0.31 9.26e-9 Myopia (pathological); LUSC cis rs11603020 1.000 rs11603020 chr11:57374332 C/T cg23127183 chr11:57508653 C11orf31 0.44 6.05 0.31 3.99e-9 Blood protein levels; LUSC cis rs1044826 0.913 rs9831108 chr3:139098357 A/C cg00490450 chr3:139108681 COPB2 0.55 7.39 0.37 1.18e-12 Obesity-related traits; LUSC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.62 0.34 1.46e-10 Schizophrenia; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg27497049 chr8:94712646 FAM92A1 0.44 5.96 0.31 6.35e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11190604 1.000 rs10883504 chr10:102280687 G/A cg07080220 chr10:102295463 HIF1AN 0.7 9.31 0.45 1.75e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs4891159 0.660 rs4891160 chr18:74102135 C/T cg24786174 chr18:74118243 ZNF516 0.69 12.39 0.56 2.96e-29 Longevity; LUSC trans rs7726839 0.540 rs3762951 chr5:662613 C/G cg11887960 chr12:57824829 NA 0.52 6.6 0.34 1.59e-10 Obesity-related traits; LUSC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg11941060 chr3:133502564 NA 0.62 10.16 0.49 2.7e-21 Iron status biomarkers; LUSC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.66 -0.39 2.07e-13 Bipolar disorder; LUSC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg27121462 chr16:89883253 FANCA 0.54 8.65 0.43 2.21e-16 Vitiligo; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg27523951 chr13:46038867 COG3 0.38 6.21 0.32 1.57e-9 Triglycerides; LUSC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg09877947 chr5:131593287 PDLIM4 0.4 6.39 0.33 5.42e-10 Breast cancer;Mosquito bite size; LUSC cis rs909674 0.865 rs5757683 chr22:39850174 G/A cg05872129 chr22:39784769 NA -0.53 -8.79 -0.43 7.83e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg23082867 chr19:19030255 DDX49;COPE 0.37 6.25 0.32 1.26e-9 Metabolite levels (Pyroglutamine); LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 6.49 0.33 3.19e-10 Platelet count; LUSC cis rs1044826 0.642 rs9833307 chr3:139181370 G/A cg15131784 chr3:139108705 COPB2 0.4 6.48 0.33 3.22e-10 Obesity-related traits; LUSC cis rs11122272 0.735 rs2808585 chr1:231514218 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs6964587 0.869 rs7793946 chr7:91520628 T/C cg22709100 chr7:91322751 NA -0.4 -5.82 -0.3 1.38e-8 Breast cancer; LUSC trans rs7824557 0.603 rs2249804 chr8:11215617 C/G cg15556689 chr8:8085844 FLJ10661 0.55 8.1 0.41 1.07e-14 Retinal vascular caliber; LUSC cis rs9399401 0.845 rs263185 chr6:142861729 G/A cg03128060 chr6:142623767 GPR126 0.32 5.95 0.31 6.72e-9 Chronic obstructive pulmonary disease; LUSC cis rs3007168 1.000 rs2999365 chr14:51600192 A/G cg23942311 chr14:51606299 NA 0.35 5.7 0.3 2.61e-8 Cancer; LUSC cis rs8017423 0.967 rs57793584 chr14:90714833 G/A cg14092571 chr14:90743983 NA -0.36 -5.87 -0.31 1.04e-8 Mortality in heart failure; LUSC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg03188948 chr7:1209495 NA 0.7 8.02 0.4 1.85e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg17279839 chr7:150038598 RARRES2 0.51 7.38 0.37 1.29e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs853679 0.546 rs493161 chr6:27850714 A/T cg08798685 chr6:27730294 NA -0.7 -6.08 -0.32 3.22e-9 Depression; LUSC cis rs7503807 1.000 rs8079537 chr17:78600818 A/G cg09596252 chr17:78655493 RPTOR 0.45 7.57 0.38 3.67e-13 Obesity; LUSC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg02086790 chr16:375327 AXIN1 -0.39 -6.03 -0.31 4.36e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs9467711 0.720 rs35627490 chr6:26462104 C/T cg09904177 chr6:26538194 HMGN4 -0.8 -6.37 -0.33 6.31e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs2204008 0.775 rs12369238 chr12:38176051 A/G cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.44e-10 Bladder cancer; LUSC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg12403142 chr1:92012408 NA -0.37 -6.09 -0.32 3.16e-9 Breast cancer; LUSC cis rs1670533 1.000 rs10902752 chr4:1056199 C/T cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.67 0.65 7.13e-42 Heart rate; LUSC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.65 7.95 0.4 2.89e-14 Lung function (FEV1/FVC); LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg00166722 chr3:10149974 C3orf24 0.62 8.7 0.43 1.55e-16 Alzheimer's disease; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg02951883 chr7:2050386 MAD1L1 -0.64 -12.37 -0.56 3.35e-29 Bipolar disorder and schizophrenia; LUSC cis rs4845459 0.967 rs6677595 chr1:152590187 C/T cg08895932 chr1:152778580 LCE1C -0.36 -6.26 -0.32 1.17e-9 Psoriasis; LUSC cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg07828340 chr4:882639 GAK 1.12 10.96 0.51 4.38e-24 Intelligence (multi-trait analysis); LUSC cis rs4077468 1.000 rs9662221 chr1:205915745 G/T cg07157834 chr1:205819609 PM20D1 -0.42 -5.92 -0.31 8.05e-9 Cystic fibrosis-related diabetes; LUSC cis rs2361718 0.568 rs1042397 chr17:78092063 G/A cg21238619 chr17:78079768 GAA -0.3 -5.75 -0.3 2.05e-8 Yeast infection; LUSC cis rs738322 0.934 rs84473 chr22:38557326 T/C cg25457927 chr22:38595422 NA -0.37 -7.62 -0.39 2.57e-13 Cutaneous nevi; LUSC trans rs672889 0.520 rs312953 chr2:21339932 G/A cg20757404 chr19:378427 NA 0.37 6.02 0.31 4.62e-9 Cholesterol, total; LUSC cis rs3126085 0.935 rs4421596 chr1:152181673 G/A cg26876637 chr1:152193138 HRNR 0.42 5.89 0.31 9.39e-9 Atopic dermatitis; LUSC cis rs11637445 0.589 rs7497457 chr15:68132723 C/A cg08079166 chr15:68083412 MAP2K5 0.35 7.1 0.36 7.57e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7264396 0.790 rs11697903 chr20:34272224 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.65 -0.47 1.37e-19 Total cholesterol levels; LUSC trans rs11098499 0.820 rs12503082 chr4:120284317 A/G cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs477692 0.905 rs524545 chr10:131411840 A/C cg11019008 chr10:131425282 MGMT -0.42 -6.43 -0.33 4.29e-10 Response to temozolomide; LUSC trans rs61931739 0.534 rs11052957 chr12:33995354 G/A cg13010199 chr12:38710504 ALG10B 0.5 7.54 0.38 4.5e-13 Morning vs. evening chronotype; LUSC trans rs330048 0.545 rs11774353 chr8:9153127 C/T cg15556689 chr8:8085844 FLJ10661 0.47 6.59 0.34 1.69e-10 Systemic lupus erythematosus; LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18301423 chr5:131593218 PDLIM4 0.47 7.42 0.38 9.66e-13 Acylcarnitine levels; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg08677398 chr8:58056175 NA 0.54 6.99 0.36 1.48e-11 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.958 rs1838955 chr6:86565449 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.83 -0.35 4.14e-11 Response to antipsychotic treatment; LUSC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg09035930 chr12:129282057 SLC15A4 -0.66 -13.32 -0.59 8.98e-33 Systemic lupus erythematosus; LUSC cis rs2908197 0.762 rs2908192 chr7:75949617 C/T cg10167463 chr7:75959203 YWHAG -0.38 -5.75 -0.3 2e-8 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg22532475 chr10:104410764 TRIM8 -0.41 -8.5 -0.42 6.24e-16 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg24503407 chr1:205819492 PM20D1 0.9 17.05 0.68 2.53e-47 Menarche (age at onset); LUSC cis rs17401966 0.838 rs12120191 chr1:10345772 A/G cg19773385 chr1:10388646 KIF1B -0.5 -8.74 -0.43 1.19e-16 Hepatocellular carcinoma; LUSC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg05340658 chr4:99064831 C4orf37 0.64 10.93 0.51 5.73e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11141652 chr22:24348549 GSTTP1 -0.38 -5.7 -0.3 2.61e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg18876405 chr7:65276391 NA 0.67 11.85 0.54 2.92e-27 Aortic root size; LUSC cis rs6138458 1.000 rs7268095 chr20:24972333 C/T cg06937882 chr20:24974362 C20orf3 -0.44 -7.65 -0.39 2.15e-13 Blood protein levels; LUSC cis rs9814567 1.000 rs4955485 chr3:134295843 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.55 -0.6 1.2e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs877282 0.891 rs11595385 chr10:800539 A/G cg22713356 chr15:30763199 NA 1.14 15.73 0.65 3.98e-42 Uric acid levels; LUSC cis rs9300255 0.507 rs1727302 chr12:123632930 G/A cg05973401 chr12:123451056 ABCB9 0.54 7.34 0.37 1.63e-12 Neutrophil percentage of white cells; LUSC cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg09184832 chr6:79620586 NA -0.44 -7.01 -0.36 1.33e-11 Intelligence (multi-trait analysis); LUSC cis rs911119 0.955 rs7265178 chr20:23603382 C/G cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -7.52 -0.38 5.25e-13 Personality dimensions; LUSC cis rs4974559 0.947 rs12639938 chr4:1343135 G/C cg02980000 chr4:1222292 CTBP1 0.73 7.25 0.37 2.9e-12 Systolic blood pressure; LUSC cis rs4906332 1.000 rs34479426 chr14:103881823 G/C cg04998671 chr14:104000505 TRMT61A -0.46 -7.22 -0.37 3.44e-12 Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06367659 chr22:50919817 ADM2 0.68 6.06 0.31 3.77e-9 Cognitive performance; LUSC cis rs1728785 1.000 rs8058314 chr16:68584151 G/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs7712401 0.601 rs30048 chr5:122270393 A/G cg19077854 chr5:122220652 SNX24 0.4 8.59 0.43 3.34e-16 Mean platelet volume; LUSC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg05802129 chr4:122689817 NA -0.5 -8.12 -0.41 9.17e-15 Type 2 diabetes; LUSC cis rs2731664 0.792 rs2630767 chr5:176870700 T/C cg23176889 chr5:176863531 GRK6 -0.66 -13.22 -0.59 2.23e-32 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.800 rs9892675 chr17:37549200 C/T cg07936489 chr17:37558343 FBXL20 0.89 12.29 0.56 6.97e-29 Glomerular filtration rate (creatinine); LUSC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs28602670 1 rs28602670 chr15:78768167 C/G cg24631222 chr15:78858424 CHRNA5 0.64 8.5 0.42 6.2e-16 Post bronchodilator FEV1; LUSC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg11752832 chr7:134001865 SLC35B4 0.5 7.59 0.38 3.15e-13 Mean platelet volume; LUSC cis rs7000551 0.689 rs6984908 chr8:22316901 A/G cg12081754 chr8:22256438 SLC39A14 -0.45 -6.95 -0.36 1.89e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC cis rs1865760 1.000 rs6910174 chr6:25904414 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.85 0.35 3.49e-11 Height; LUSC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.71 0.3 2.55e-8 Intelligence (multi-trait analysis); LUSC cis rs7296418 0.699 rs1109559 chr12:123757861 C/T cg00376283 chr12:123451042 ABCB9 0.71 10.94 0.51 5.25e-24 Platelet count; LUSC cis rs7561273 0.609 rs6720226 chr2:24295853 A/G cg20701182 chr2:24300061 SF3B14 0.45 5.77 0.3 1.78e-8 Quantitative traits; LUSC cis rs870825 0.929 rs1405939 chr4:185591444 C/T cg04058563 chr4:185651563 MLF1IP 0.76 9.24 0.45 2.93e-18 Blood protein levels; LUSC cis rs17286411 0.814 rs12708918 chr16:71984941 C/G cg03805757 chr16:71968109 PKD1L3 0.4 6.51 0.34 2.73e-10 Blood protein levels; LUSC cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg06627628 chr2:24431161 ITSN2 -0.61 -7.4 -0.38 1.09e-12 Lymphocyte counts; LUSC cis rs12946454 0.696 rs4792819 chr17:43247957 A/C cg10701640 chr17:43249399 NA 0.5 12.06 0.55 4.93e-28 Systolic blood pressure; LUSC cis rs10484885 0.680 rs72921943 chr6:90581542 A/C cg13799429 chr6:90582589 CASP8AP2 -0.99 -13.64 -0.6 5.62e-34 QRS interval (sulfonylurea treatment interaction); LUSC cis rs12682352 0.602 rs1473029 chr8:8668917 A/C cg08975724 chr8:8085496 FLJ10661 0.42 5.94 0.31 7.16e-9 Neuroticism; LUSC trans rs11098499 0.954 rs11722872 chr4:120233030 G/C cg25214090 chr10:38739885 LOC399744 0.53 7.61 0.38 2.81e-13 Corneal astigmatism; LUSC cis rs73200209 0.744 rs61939693 chr12:116540478 G/A cg01776926 chr12:116560359 MED13L -0.49 -6.03 -0.31 4.36e-9 Total body bone mineral density; LUSC cis rs3824867 0.920 rs7111873 chr11:47469439 A/G cg20307385 chr11:47447363 PSMC3 0.64 9.48 0.46 4.83e-19 Mean corpuscular hemoglobin; LUSC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg23758822 chr17:41437982 NA -0.98 -19.45 -0.73 7.03e-57 Menopause (age at onset); LUSC cis rs9549367 0.865 rs9549366 chr13:113907644 G/A cg00898013 chr13:113819073 PROZ -0.53 -7.85 -0.39 5.78e-14 Platelet distribution width; LUSC cis rs6940638 0.513 rs4424065 chr6:27036456 C/T cg12292205 chr6:26970375 C6orf41 -0.49 -8.07 -0.4 1.31e-14 Intelligence (multi-trait analysis); LUSC cis rs3772130 1.000 rs11714406 chr3:121372513 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.68 9.98 0.48 1.07e-20 Cognitive performance; LUSC trans rs61931739 0.534 rs1608912 chr12:34008574 C/T cg13010199 chr12:38710504 ALG10B 0.47 7.6 0.38 3.03e-13 Morning vs. evening chronotype; LUSC cis rs9929218 0.559 rs12923775 chr16:68756450 C/T cg01251360 chr16:68772225 CDH1 -0.26 -6.1 -0.32 2.96e-9 Colorectal cancer; LUSC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg24250549 chr1:154909240 PMVK 0.58 9.36 0.46 1.23e-18 Prostate cancer; LUSC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.65 6.89 0.35 2.82e-11 Mean platelet volume; LUSC cis rs62400317 0.859 rs62400293 chr6:45233580 A/T cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs13064411 0.735 rs13098166 chr3:113210038 A/G cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs9560113 1.000 rs2104790 chr13:112177412 C/T cg14154082 chr13:112174009 NA 0.38 7.76 0.39 1.03e-13 Menarche (age at onset); LUSC cis rs2019216 0.502 rs1842113 chr17:21872137 G/A cg22648282 chr17:21454238 C17orf51 -0.5 -7.26 -0.37 2.8e-12 Pelvic organ prolapse; LUSC cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.9 0.31 8.88e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg16240275 chr20:61666158 NCRNA00029 0.42 9.36 0.46 1.17e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg00033643 chr7:134001901 SLC35B4 -0.42 -6.35 -0.33 6.94e-10 Mean platelet volume; LUSC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg23758822 chr17:41437982 NA 1.04 19.84 0.74 1.98e-58 Menopause (age at onset); LUSC trans rs804280 0.518 rs34266352 chr8:11791462 G/A cg15556689 chr8:8085844 FLJ10661 0.58 8.8 0.43 7.22e-17 Myopia (pathological); LUSC cis rs61931739 0.635 rs1405024 chr12:33937939 A/T cg06521331 chr12:34319734 NA 0.41 6.73 0.35 7.5e-11 Morning vs. evening chronotype; LUSC cis rs1568889 0.838 rs10835273 chr11:28156598 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.66 0.57 2.85e-30 Bipolar disorder; LUSC cis rs6693567 0.545 rs35705743 chr1:150451832 G/A cg15654264 chr1:150340011 RPRD2 0.43 6.81 0.35 4.66e-11 Migraine; LUSC trans rs7746199 0.736 rs17749927 chr6:27669976 A/G cg06606381 chr12:133084897 FBRSL1 -0.95 -8.61 -0.43 2.88e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4595586 0.679 rs7955725 chr12:39322903 C/T cg26384229 chr12:38710491 ALG10B 0.47 6.48 0.33 3.33e-10 Morning vs. evening chronotype; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg25703541 chr22:24373054 LOC391322 -0.9 -14.58 -0.62 1.38e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7000551 0.700 rs2461491 chr8:22361252 C/T cg12081754 chr8:22256438 SLC39A14 -0.41 -6.21 -0.32 1.59e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs17401966 0.838 rs11121551 chr1:10435170 T/C cg19773385 chr1:10388646 KIF1B -0.51 -8.88 -0.44 4.31e-17 Hepatocellular carcinoma; LUSC cis rs61931739 0.500 rs7971957 chr12:34477558 C/T cg06521331 chr12:34319734 NA -0.42 -6.84 -0.35 3.88e-11 Morning vs. evening chronotype; LUSC trans rs9329221 0.537 rs6601415 chr8:9976805 C/A cg21775007 chr8:11205619 TDH 0.44 6.26 0.32 1.2e-9 Neuroticism; LUSC trans rs61931739 0.534 rs10844725 chr12:34009504 C/A cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 3.03e-25 Morning vs. evening chronotype; LUSC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg22823121 chr1:150693482 HORMAD1 0.5 7.32 0.37 1.86e-12 Melanoma; LUSC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg24562669 chr7:97807699 LMTK2 0.34 5.95 0.31 6.83e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1371867 0.846 rs1660312 chr8:101330634 C/G cg00191853 chr8:101177733 SPAG1 -0.41 -6.49 -0.33 3.05e-10 Atrioventricular conduction; LUSC cis rs10484885 0.818 rs117562849 chr6:90249804 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -7.19 -0.37 4.18e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1348850 0.793 rs13020788 chr2:178480714 C/A cg22681709 chr2:178499509 PDE11A -0.57 -10.75 -0.51 2.45e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs656319 0.647 rs13264668 chr8:9884877 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.59 -0.34 1.72e-10 Myopia (pathological); LUSC cis rs2730245 0.527 rs842707 chr7:158656012 C/T cg11984989 chr7:158649758 WDR60 1.14 13.85 0.6 8.5e-35 Height; LUSC cis rs11098499 0.909 rs28571712 chr4:120375980 G/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg04369109 chr6:150039330 LATS1 -0.56 -8.22 -0.41 4.62e-15 Lung cancer; LUSC cis rs73198271 0.855 rs57301822 chr8:8608642 C/T cg01851573 chr8:8652454 MFHAS1 0.53 7.94 0.4 3.02e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg19774624 chr17:42201019 HDAC5 0.71 10.39 0.49 4.28e-22 Total body bone mineral density; LUSC cis rs4363385 0.818 rs378010 chr1:153007987 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.91 -0.4 3.76e-14 Inflammatory skin disease; LUSC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg15468180 chr1:107600409 PRMT6 -0.39 -6.25 -0.32 1.24e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg13012494 chr21:47604986 C21orf56 0.45 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg22875332 chr1:76189707 ACADM 0.77 10.41 0.49 3.77e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs68170813 0.559 rs2107318 chr7:106845969 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.82 -0.47 3.71e-20 Coronary artery disease; LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.95 -0.36 1.88e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2742234 0.915 rs2742233 chr10:43610558 C/T cg02780029 chr10:43622663 RET -0.34 -6.22 -0.32 1.44e-9 Hirschsprung disease; LUSC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg07701084 chr6:150067640 NUP43 0.57 8.9 0.44 3.64e-17 Lung cancer; LUSC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.76 9.6 0.47 1.92e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34779708 0.931 rs10466072 chr10:35402756 C/T cg03585969 chr10:35415529 CREM 0.59 8.81 0.43 7.15e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs4295623 0.789 rs12541318 chr8:11594970 G/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.34 -0.37 1.64e-12 Morning vs. evening chronotype; LUSC cis rs12760731 0.720 rs12035174 chr1:178314311 A/T cg00404053 chr1:178313656 RASAL2 0.57 6.06 0.31 3.65e-9 Obesity-related traits; LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.4 -0.33 5.38e-10 Bipolar disorder and schizophrenia; LUSC cis rs2777491 1.000 rs316613 chr15:41747598 G/A cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.32 -0.59 9.19e-33 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07627390 chr16:23652638 PALB2;DCTN5 0.43 6.69 0.34 9.35e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs829880 0.570 rs4488248 chr12:98853688 G/C cg25150519 chr12:98850993 NA 0.75 11.92 0.55 1.6e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs1595825 0.627 rs77353793 chr2:198470546 C/T cg00982548 chr2:198649783 BOLL -0.53 -6.22 -0.32 1.46e-9 Ulcerative colitis; LUSC cis rs4561483 0.798 rs33629 chr16:11997490 G/A cg08843971 chr16:11963173 GSPT1 -0.42 -6.02 -0.31 4.59e-9 Testicular germ cell tumor; LUSC trans rs10098647 0.632 rs74459651 chr8:61111651 T/C cg09970348 chr3:183978600 ECE2;CAMK2N2 0.46 6.15 0.32 2.26e-9 Obesity-related traits; LUSC cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg17509989 chr5:176798049 RGS14 0.66 10.5 0.5 1.81e-22 Hemoglobin concentration;Hematocrit; LUSC cis rs9435341 0.860 rs12406721 chr1:107563243 G/T cg15468180 chr1:107600409 PRMT6 0.41 6.13 0.32 2.54e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs865483 0.895 rs2107105 chr17:35835080 C/T cg06716730 chr17:35851459 DUSP14 0.27 5.97 0.31 6.23e-9 Monocyte count; LUSC trans rs1814175 0.817 rs10769648 chr11:50013992 T/C cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs9325144 0.532 rs12812406 chr12:38719802 G/A cg13010199 chr12:38710504 ALG10B -0.47 -7.17 -0.37 4.99e-12 Morning vs. evening chronotype; LUSC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg25456477 chr12:86230367 RASSF9 0.35 6.18 0.32 1.84e-9 Major depressive disorder; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg08472276 chr7:1133186 C7orf50;GPER -0.39 -6.48 -0.33 3.3e-10 Longevity;Endometriosis; LUSC cis rs7246967 0.673 rs12979848 chr19:22820798 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs9790314 0.905 rs6789388 chr3:160970437 G/A cg03342759 chr3:160939853 NMD3 -0.52 -8.74 -0.43 1.16e-16 Morning vs. evening chronotype; LUSC cis rs1005224 0.963 rs11623813 chr14:76138194 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.66 -8.97 -0.44 2.15e-17 Large artery stroke; LUSC cis rs4737010 0.536 rs6474365 chr8:41662940 G/T cg17182837 chr8:41585554 ANK1 -0.36 -6.52 -0.34 2.59e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg13708869 chr17:38444121 CDC6 0.39 6.06 0.31 3.62e-9 N-glycan levels; LUSC cis rs13256369 0.802 rs13280101 chr8:8562773 G/A cg18904891 chr8:8559673 CLDN23 0.6 8.08 0.4 1.2e-14 Obesity-related traits; LUSC cis rs12137294 0.866 rs1077883 chr1:205210415 G/T cg21643547 chr1:205240462 TMCC2 -0.35 -6.43 -0.33 4.48e-10 Red cell distribution width; LUSC cis rs6714710 0.603 rs4311104 chr2:98424802 A/G cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs62400317 0.762 rs12198308 chr6:44911886 C/T cg18551225 chr6:44695536 NA -0.48 -7.69 -0.39 1.65e-13 Total body bone mineral density; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg13453750 chr1:205783389 SLC41A1 0.32 6.38 0.33 5.76e-10 Menarche (age at onset); LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.66 -0.43 2.01e-16 Bipolar disorder; LUSC cis rs6723226 0.732 rs390480 chr2:32510072 A/C cg02381751 chr2:32503542 YIPF4 -0.56 -8.86 -0.44 4.75e-17 Intelligence (multi-trait analysis); LUSC cis rs1355223 0.506 rs11032894 chr11:34865544 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.8 -0.35 4.79e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs4356932 1.000 rs10017431 chr4:76955406 T/C cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.59 0.38 3.18e-13 Vitiligo; LUSC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.69 0.54 1.11e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs11098499 0.754 rs34425882 chr4:120253177 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.48 0.33 3.35e-10 Corneal astigmatism; LUSC cis rs1044826 1.000 rs10935323 chr3:139110135 T/G cg00490450 chr3:139108681 COPB2 0.56 7.38 0.37 1.29e-12 Obesity-related traits; LUSC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg09034736 chr1:150693464 HORMAD1 0.42 5.85 0.3 1.16e-8 Melanoma; LUSC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.8 0.47 4.42e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7589342 0.899 rs10185551 chr2:106492201 A/C cg14210321 chr2:106509881 NCK2 -0.56 -8.43 -0.42 1.02e-15 Addiction; LUSC cis rs6964587 1.000 rs6968870 chr7:91661111 G/C cg22117172 chr7:91764530 CYP51A1 0.32 5.65 0.3 3.43e-8 Breast cancer; LUSC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg13206674 chr6:150067644 NUP43 0.62 9.9 0.48 2e-20 Lung cancer; LUSC cis rs796364 0.806 rs79725795 chr2:201083534 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.99 -0.4 2.21e-14 Schizophrenia; LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg14092988 chr3:52407081 DNAH1 0.31 6.18 0.32 1.82e-9 Bipolar disorder; LUSC cis rs72781680 1.000 rs72781663 chr2:24221694 C/G cg08917208 chr2:24149416 ATAD2B 0.89 9.99 0.48 9.47e-21 Lymphocyte counts; LUSC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg06618935 chr21:46677482 NA -0.4 -7.99 -0.4 2.2e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.679 rs2218271 chr8:58052446 T/A cg11062466 chr8:58055876 NA 0.49 6.52 0.34 2.59e-10 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.705 rs72645804 chr1:15868387 A/C cg17385448 chr1:15911702 AGMAT 0.38 5.79 0.3 1.61e-8 Systolic blood pressure; LUSC cis rs2070433 0.752 rs11701058 chr21:47776382 T/C cg12379764 chr21:47803548 PCNT 0.75 9.31 0.45 1.8e-18 Lymphocyte counts; LUSC cis rs11214589 0.651 rs11214596 chr11:113264511 C/G cg14159747 chr11:113255604 NA 0.3 7.8 0.39 8.03e-14 Neuroticism; LUSC trans rs2727020 0.553 rs11040400 chr11:49518296 C/A cg03929089 chr4:120376271 NA -0.96 -16.24 -0.66 4.12e-44 Coronary artery disease; LUSC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg14664628 chr15:75095509 CSK -0.58 -8.79 -0.43 7.96e-17 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02351056 chr10:126480372 METTL10 0.49 6.94 0.36 2.1e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg22963979 chr7:1858916 MAD1L1 -0.55 -8.2 -0.41 5.16e-15 Bipolar disorder and schizophrenia; LUSC cis rs7582180 0.903 rs13032368 chr2:100896112 C/T cg08017756 chr2:100939284 LONRF2 -0.36 -6.01 -0.31 4.77e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs3106136 0.967 rs3113862 chr4:95143122 A/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.1 -0.32 2.86e-9 Capecitabine sensitivity; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.43 -6.07 -0.32 3.48e-9 Alzheimer's disease (late onset); LUSC cis rs7824557 0.767 rs1897950 chr8:11169551 C/A cg21293242 chr8:11204541 TDH 0.32 5.91 0.31 8.66e-9 Retinal vascular caliber; LUSC cis rs9388451 0.531 rs9375414 chr6:126154475 G/A cg05901451 chr6:126070800 HEY2 -0.67 -10.33 -0.49 6.6e-22 Brugada syndrome; LUSC cis rs9326248 0.581 rs10892063 chr11:116896155 A/C cg26566898 chr11:117069891 TAGLN 0.34 6.46 0.33 3.77e-10 Blood protein levels; LUSC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.92 -0.35 2.35e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs12545109 0.807 rs13263281 chr8:57346582 C/A cg09654669 chr8:57350985 NA -0.6 -8.05 -0.4 1.43e-14 Obesity-related traits; LUSC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg06808227 chr14:105710500 BRF1 -0.65 -9.66 -0.47 1.29e-19 Mean platelet volume;Platelet distribution width; LUSC trans rs9393777 0.920 rs34953377 chr6:27381660 T/C cg06606381 chr12:133084897 FBRSL1 -1.03 -9.51 -0.46 3.88e-19 Intelligence (multi-trait analysis); LUSC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg12639453 chr1:2035780 PRKCZ -0.34 -7.29 -0.37 2.32e-12 Height; LUSC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.45e-28 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg09455208 chr3:40491958 NA -0.62 -11.01 -0.52 3.04e-24 Renal cell carcinoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10935138 chr17:73851978 WBP2 0.48 6.4 0.33 5.2400000000000005e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07067085 chr12:120638762 RPLP0 -0.48 -7.13 -0.36 6.38e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg06454157 chr6:167490870 NA -0.27 -6.5 -0.34 2.93e-10 Primary biliary cholangitis; LUSC cis rs7197653 0.667 rs7190070 chr16:68353983 C/T cg09835421 chr16:68378352 PRMT7 -0.8 -8.49 -0.42 6.81e-16 Magnesium levels; LUSC cis rs11676348 0.774 rs57545959 chr2:219047718 A/G cg23569941 chr2:219139048 TMBIM1;PNKD -0.39 -6.43 -0.33 4.31e-10 Ulcerative colitis; LUSC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.12 -0.36 6.51e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.64 8.2 0.41 5.13e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs1691799 0.867 rs1168344 chr12:66758213 G/A cg16791601 chr12:66731901 HELB -0.71 -12.37 -0.56 3.47e-29 White blood cell count (basophil); LUSC cis rs1843834 0.898 rs12623277 chr2:225548072 T/G cg22455342 chr2:225449267 CUL3 0.47 6.62 0.34 1.45e-10 IgE levels in asthmatics (D.p. specific); LUSC cis rs2274273 0.840 rs6573013 chr14:55735873 A/C cg04306507 chr14:55594613 LGALS3 0.56 12.96 0.58 2.05e-31 Protein biomarker; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg09693464 chr7:41744949 LOC285954 -0.47 -7.26 -0.37 2.69e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs72781680 0.898 rs55761273 chr2:23957849 A/G cg08917208 chr2:24149416 ATAD2B 0.88 9.72 0.47 7.6e-20 Lymphocyte counts; LUSC cis rs1124376 0.832 rs6793985 chr3:20136485 T/C cg05072819 chr3:20081367 KAT2B 0.67 8.19 0.41 5.56e-15 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.909 rs11723757 chr4:120299669 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.17 0.32 1.95e-9 Corneal astigmatism; LUSC cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.02 0.58 1.28e-31 Chronic sinus infection; LUSC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg27535305 chr1:53392650 SCP2 0.32 5.82 0.3 1.37e-8 Monocyte count; LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 6.53 0.34 2.49e-10 Bipolar disorder; LUSC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg06618935 chr21:46677482 NA -0.39 -7.7 -0.39 1.5700000000000001e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.29e-11 Developmental language disorder (linguistic errors); LUSC cis rs7903847 0.527 rs11189221 chr10:99198217 C/T cg20016023 chr10:99160130 RRP12 -0.26 -5.65 -0.3 3.47e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs8056893 0.714 rs6499173 chr16:68388115 G/A cg02226672 chr16:68398533 SMPD3 0.32 5.77 0.3 1.83e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.3 0.49 8.52e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs4474465 1.000 rs4474465 chr11:78204380 C/T cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg00631329 chr6:26305371 NA 0.34 5.92 0.31 7.93e-9 Intelligence (multi-trait analysis); LUSC cis rs4737010 0.501 rs2111805 chr8:41643457 G/C cg17182837 chr8:41585554 ANK1 -0.38 -6.81 -0.35 4.63e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 13.86 0.6 7.9e-35 Platelet count; LUSC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg18512352 chr11:47633146 NA -0.46 -9.22 -0.45 3.55e-18 Subjective well-being; LUSC cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs4595586 0.505 rs12827467 chr12:39374014 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.08e-9 Morning vs. evening chronotype; LUSC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg09267113 chr7:98030324 BAIAP2L1 0.39 5.89 0.31 9.63e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs76878669 0.561 rs3177514 chr11:66130358 T/G cg24851651 chr11:66362959 CCS -0.36 -5.76 -0.3 1.93e-8 Educational attainment (years of education); LUSC trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg03929089 chr4:120376271 NA -0.6 -7.21 -0.37 3.79e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg14004847 chr7:1930337 MAD1L1 -0.5 -7.44 -0.38 8.32e-13 Schizophrenia; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg18765753 chr7:1198926 ZFAND2A -0.58 -10.98 -0.51 3.77e-24 Longevity;Endometriosis; LUSC cis rs754466 0.606 rs7084705 chr10:79596675 A/G cg17075019 chr10:79541650 NA -0.69 -10.39 -0.49 4.34e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg03264133 chr6:25882463 NA -0.43 -7.36 -0.37 1.42e-12 Height; LUSC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11644478 chr21:40555479 PSMG1 0.94 18.23 0.71 5.01e-52 Cognitive function; LUSC cis rs9309711 0.961 rs11692184 chr2:3480710 C/T cg10845886 chr2:3471009 TTC15 -0.6 -7.79 -0.39 8.4e-14 Neurofibrillary tangles; LUSC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg02782426 chr3:40428986 ENTPD3 0.43 8.1 0.41 1.03e-14 Renal cell carcinoma; LUSC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg21963583 chr11:68658836 MRPL21 0.59 8.7 0.43 1.59e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1775715 0.811 rs1775741 chr10:32267284 C/T cg18675610 chr10:32216311 ARHGAP12 -0.29 -6.06 -0.31 3.64e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7917772 0.582 rs7075269 chr10:104365724 C/T cg05855489 chr10:104503620 C10orf26 -0.49 -7.45 -0.38 7.83e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8114671 0.869 rs66535333 chr20:33656666 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -5.89 -0.31 9.23e-9 Height; LUSC cis rs35272691 1 rs35272691 chr17:38157841 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.7 12.22 0.56 1.2e-28 White blood cell count (neutrophil); LUSC cis rs12950390 0.853 rs12451815 chr17:45855956 A/G cg24803719 chr17:45855879 NA -0.29 -5.79 -0.3 1.64e-8 IgG glycosylation; LUSC cis rs4664308 0.935 rs4292050 chr2:160940899 G/T cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg05855489 chr10:104503620 C10orf26 -0.61 -7.89 -0.4 4.24e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs35110281 0.837 rs7279958 chr21:45016016 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.88 0.48 2.31e-20 Mean corpuscular volume; LUSC trans rs7829975 0.688 rs6601703 chr8:8380224 A/G cg21775007 chr8:11205619 TDH 0.45 6.66 0.34 1.14e-10 Mood instability; LUSC cis rs12368653 0.616 rs1027315 chr12:58034192 T/C cg12615879 chr12:58013172 SLC26A10 0.39 9.11 0.45 7.9e-18 Multiple sclerosis; LUSC cis rs9650657 0.812 rs6993841 chr8:10632684 G/A cg27411982 chr8:10470053 RP1L1 -0.41 -6.59 -0.34 1.75e-10 Neuroticism; LUSC cis rs12618769 0.597 rs3769712 chr2:99153443 A/T cg10123293 chr2:99228465 UNC50 0.5 8.12 0.41 9.4e-15 Bipolar disorder; LUSC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 6.31 0.33 8.74e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs4555082 0.834 rs11622165 chr14:105759761 C/A cg06808227 chr14:105710500 BRF1 -0.63 -9.13 -0.45 6.81e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs1113500 0.933 rs10785834 chr1:108639101 A/C cg11967332 chr1:108735228 SLC25A24 0.39 5.84 0.3 1.24e-8 Growth-regulated protein alpha levels; LUSC trans rs67539049 1.000 rs68063127 chr8:11303726 G/C cg26241650 chr22:40417538 FAM83F 0.45 6.08 0.32 3.31e-9 Itch intensity from mosquito bite; LUSC cis rs926938 0.527 rs360594 chr1:115472401 G/A cg01522456 chr1:115632236 TSPAN2 -0.41 -6.43 -0.33 4.47e-10 Autism; LUSC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg22800045 chr5:56110881 MAP3K1 0.44 6.22 0.32 1.49e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs478304 0.934 rs498354 chr11:65528213 A/G cg05805236 chr11:65401703 PCNXL3 0.4 6.84 0.35 3.82e-11 Acne (severe); LUSC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.46 -0.33 3.73e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg26566898 chr11:117069891 TAGLN 0.32 5.99 0.31 5.46e-9 Blood protein levels; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg19318889 chr4:1322082 MAEA -0.71 -12.13 -0.55 2.74e-28 Obesity-related traits; LUSC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg20307385 chr11:47447363 PSMC3 0.45 5.86 0.31 1.09e-8 Subjective well-being; LUSC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg12560992 chr17:57184187 TRIM37 0.8 14.17 0.61 5.27e-36 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.561 rs3087978 chr6:86388223 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 5.68 0.3 2.86e-8 Response to antipsychotic treatment; LUSC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg02269571 chr22:50332266 NA -0.75 -9.41 -0.46 8.48e-19 Schizophrenia; LUSC cis rs10193935 0.892 rs13413028 chr2:42394865 C/G cg27598129 chr2:42591480 NA -0.59 -7.96 -0.4 2.75e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs16937 0.521 rs78176224 chr1:205178609 G/A cg21643547 chr1:205240462 TMCC2 -0.33 -5.71 -0.3 2.52e-8 Schizophrenia; LUSC cis rs9399401 0.961 rs6937121 chr6:142707133 G/T cg03128060 chr6:142623767 GPR126 -0.34 -6.19 -0.32 1.8e-9 Chronic obstructive pulmonary disease; LUSC cis rs644799 0.544 rs555556 chr11:95618425 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.66 0.47 1.3e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs6600671 0.967 rs11249349 chr1:121179169 G/C cg08727972 chr1:148025634 NBPF14 0.46 6.3 0.33 9.5e-10 Hip geometry; LUSC cis rs11098499 0.605 rs6833140 chr4:120266822 G/A cg24375607 chr4:120327624 NA 0.69 10.92 0.51 6.06e-24 Corneal astigmatism; LUSC cis rs12042107 0.818 rs12568187 chr1:91193691 T/C cg13456504 chr1:91191583 NA 0.41 6.79 0.35 5.29e-11 Educational attainment; LUSC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg23283495 chr1:209979779 IRF6 -0.63 -7.97 -0.4 2.47e-14 Cleft lip with or without cleft palate; LUSC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg03929089 chr4:120376271 NA -1.04 -19.98 -0.74 5.38e-59 Height; LUSC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg20891283 chr12:69753455 YEATS4 -0.58 -7.69 -0.39 1.63e-13 Response to diuretic therapy; LUSC cis rs5758511 0.680 rs5751243 chr22:42617177 T/C cg00645731 chr22:42541494 CYP2D7P1 0.56 9.75 0.47 6.24e-20 Birth weight; LUSC cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg16586182 chr3:47516702 SCAP -0.5 -6.16 -0.32 2.11e-9 Birth weight; LUSC cis rs4803468 0.967 rs4802116 chr19:41905540 C/T cg09537434 chr19:41945824 ATP5SL -0.89 -15.81 -0.65 2.07e-42 Height; LUSC cis rs6690583 0.623 rs74689037 chr1:85439268 C/T cg22153463 chr1:85462885 MCOLN2 0.63 6.02 0.31 4.6e-9 Serum sulfate level; LUSC cis rs2996428 0.601 rs10909804 chr1:3770929 A/G cg17848003 chr1:3704513 LRRC47 -0.32 -6.1 -0.32 2.89e-9 Red cell distribution width; LUSC trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg23505145 chr19:12996616 KLF1 0.64 10.74 0.51 2.69e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg03804128 chr16:635623 NA 0.33 6.65 0.34 1.23e-10 Height; LUSC cis rs864537 0.618 rs2995089 chr1:167431193 G/A cg22356347 chr1:167427500 CD247 -0.35 -8.26 -0.41 3.52e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs9788682 0.747 rs7177514 chr15:78907406 C/G cg06917634 chr15:78832804 PSMA4 -0.49 -6.5 -0.34 2.91e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg08859206 chr1:53392774 SCP2 -0.55 -9.29 -0.45 2.06e-18 Monocyte count; LUSC cis rs6754311 0.593 rs7608045 chr2:136413359 T/C cg07169764 chr2:136633963 MCM6 0.55 7.25 0.37 2.94e-12 Mosquito bite size; LUSC trans rs11165623 0.792 rs1931180 chr1:96914049 C/T cg10631902 chr5:14652156 NA -0.53 -8.75 -0.43 1.1e-16 Hip circumference;Waist circumference; LUSC cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -7.24 -0.37 3.19e-12 Chronic sinus infection; LUSC cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg03877680 chr5:178157825 ZNF354A 0.61 8.03 0.4 1.68e-14 Neutrophil percentage of white cells; LUSC cis rs11190604 1.000 rs11190570 chr10:102227702 G/C cg07080220 chr10:102295463 HIF1AN 0.64 8.56 0.42 4.06e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9811920 0.598 rs793470 chr3:99548274 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.51 7.8 0.39 8.2e-14 Axial length; LUSC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.72e-21 Monocyte count; LUSC cis rs4363385 0.747 rs7529110 chr1:152966247 A/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.66 -0.39 2.03e-13 Inflammatory skin disease; LUSC cis rs9467711 0.790 rs13195401 chr6:26463574 G/T cg09904177 chr6:26538194 HMGN4 -0.79 -5.88 -0.31 1e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs7202877 0.611 rs4888395 chr16:75413715 T/G cg03315344 chr16:75512273 CHST6 0.43 6.42 0.33 4.69e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg13683864 chr3:40499215 RPL14 -1.15 -21.24 -0.76 5.91e-64 Renal cell carcinoma; LUSC cis rs8114671 0.562 rs6120739 chr20:33405227 A/G cg07148914 chr20:33460835 GGT7 0.52 7.8 0.39 8.1e-14 Height; LUSC cis rs6464929 0.955 rs6952916 chr7:148724945 T/C cg23583168 chr7:148888333 NA 0.46 5.71 0.3 2.46e-8 Pediatric bone mineral content (hip); LUSC cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.99 0.31 5.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg05368731 chr17:41323189 NBR1 0.81 13.88 0.6 6.48e-35 Menopause (age at onset); LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg01238044 chr22:24384105 GSTT1 -0.73 -12.34 -0.56 4.3e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9463078 0.605 rs17422760 chr6:44885288 C/T cg25276700 chr6:44698697 NA 0.29 6.16 0.32 2.06e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg07677032 chr17:61819896 STRADA 0.53 8.61 0.43 2.94e-16 Prudent dietary pattern; LUSC cis rs7267979 0.706 rs6138542 chr20:25207773 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.76 15.2 0.64 5.15e-40 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4906332 1.000 rs10459573 chr14:103925457 A/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.78e-12 Coronary artery disease; LUSC cis rs3806843 1.000 rs6898906 chr5:140169299 C/G cg26395211 chr5:140044315 WDR55 -0.37 -5.77 -0.3 1.78e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg14403583 chr14:105418241 AHNAK2 -0.58 -9.66 -0.47 1.28e-19 Rheumatoid arthritis; LUSC cis rs2742417 0.603 rs2742371 chr3:45782763 G/A cg10512202 chr3:45649293 LIMD1 0.36 6.11 0.32 2.71e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg00677455 chr12:58241039 CTDSP2 0.5 7.6 0.38 3.04e-13 Intelligence (multi-trait analysis); LUSC cis rs4589502 0.841 rs55855162 chr15:67140523 C/A cg12317470 chr15:67143691 NA 0.66 6.43 0.33 4.51e-10 Lung cancer (smoking interaction); LUSC cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.76 0.39 1.03e-13 Colorectal cancer; LUSC cis rs41271473 0.948 rs72750016 chr1:228816786 G/C cg10167378 chr1:228756711 NA 0.59 7.18 0.37 4.58e-12 Chronic lymphocytic leukemia; LUSC cis rs13114435 0.510 rs6823077 chr4:183833942 A/C cg00486011 chr4:183851557 NA 0.27 5.77 0.3 1.81e-8 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00558053 chr19:1905303 ADAT3;SCAMP4 -0.43 -6.36 -0.33 6.46e-10 Electrocardiographic conduction measures; LUSC cis rs7833787 1.000 rs12546946 chr8:18703078 C/G cg17701159 chr8:18705777 PSD3 -0.38 -6.21 -0.32 1.55e-9 Obesity-related traits; LUSC trans rs10880689 1 rs10880689 chr12:37930102 A/G cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.26e-10 Resting heart rate; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg16145915 chr7:1198662 ZFAND2A -0.64 -12.38 -0.56 3.08e-29 Longevity;Endometriosis; LUSC cis rs10464366 0.746 rs12670510 chr7:39142146 A/G cg15212455 chr7:39170539 POU6F2 0.6 9.6 0.46 2.02e-19 IgG glycosylation; LUSC cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg27129171 chr3:47204927 SETD2 0.72 12.74 0.57 1.47e-30 Colorectal cancer; LUSC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg26597838 chr10:835615 NA 1.21 16.6 0.67 1.46e-45 Eosinophil percentage of granulocytes; LUSC cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg03146154 chr1:46216737 IPP 0.51 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg05863683 chr7:1912471 MAD1L1 0.3 5.87 0.31 1.08e-8 Bipolar disorder and schizophrenia; LUSC cis rs35146811 0.735 rs6465766 chr7:99785671 A/G cg22906224 chr7:99728672 NA 0.46 6.5 0.34 2.94e-10 Coronary artery disease; LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg08859206 chr1:53392774 SCP2 0.76 14.68 0.63 5.27e-38 Monocyte count; LUSC trans rs62103177 0.733 rs62103193 chr18:77629217 C/T cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.85 0.47 2.83e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.04 -0.31 4.18e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6456156 0.586 rs9457261 chr6:167467679 A/G cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg20607287 chr7:12443886 VWDE -0.61 -6.34 -0.33 7.27e-10 Coronary artery disease; LUSC cis rs4805272 0.512 rs7260055 chr19:29341599 G/A cg12756686 chr19:29218302 NA 0.56 6.32 0.33 8.42e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs17641971 0.645 rs10504073 chr8:50024944 C/T cg00325661 chr8:49890786 NA 0.36 5.77 0.3 1.82e-8 Blood metabolite levels; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg11645453 chr3:52864694 ITIH4 0.34 7.95 0.4 2.95e-14 Bipolar disorder; LUSC cis rs1018836 0.847 rs4735225 chr8:91569100 G/C cg16814680 chr8:91681699 NA -0.76 -12.82 -0.57 6.94e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg02153584 chr22:29168773 CCDC117 0.59 8.89 0.44 3.81e-17 Lymphocyte counts; LUSC cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg22509189 chr2:225307070 NA -0.47 -6.13 -0.32 2.41e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg23172400 chr8:95962367 TP53INP1 0.34 6.63 0.34 1.33e-10 Type 2 diabetes; LUSC cis rs79387448 0.701 rs11465586 chr2:102982709 C/G cg09003973 chr2:102972529 NA 1.21 12.78 0.57 9.76e-31 Gut microbiota (bacterial taxa); LUSC cis rs9807841 0.545 rs4804514 chr19:10764203 G/T cg09936142 chr19:10668400 KRI1 -0.41 -6.68 -0.34 9.95e-11 Inflammatory skin disease; LUSC cis rs6500395 1.000 rs9931123 chr16:48614293 G/T cg04672837 chr16:48644449 N4BP1 0.49 7.46 0.38 7.78e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg18252515 chr7:66147081 NA -1.19 -12.84 -0.57 5.85e-31 Diabetic kidney disease; LUSC trans rs11098499 0.913 rs56122576 chr4:120129336 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.29 0.33 1.01e-9 Corneal astigmatism; LUSC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg01849466 chr14:104193079 ZFYVE21 -0.53 -7.78 -0.39 9.23e-14 Reticulocyte count; LUSC cis rs9646944 0.501 rs34946515 chr2:103043320 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.55 0.34 2.23e-10 Blood protein levels; LUSC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg09839279 chr12:125627357 AACS -0.34 -6.48 -0.33 3.32e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7683537 0.692 rs12509936 chr4:185662203 G/A cg07424746 chr4:185654737 MLF1IP -0.52 -5.79 -0.3 1.62e-8 Systemic lupus erythematosus; LUSC cis rs9300255 0.722 rs67624109 chr12:123824635 C/T cg13010344 chr12:123464640 ARL6IP4 0.5 6.28 0.33 1.03e-9 Neutrophil percentage of white cells; LUSC cis rs4072705 0.615 rs6478666 chr9:127249343 C/G cg13476313 chr9:127244764 NR5A1 -0.33 -6.38 -0.33 5.98e-10 Menarche (age at onset); LUSC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg06637938 chr14:75390232 RPS6KL1 -0.51 -8.0 -0.4 2.05e-14 Height; LUSC cis rs6696846 0.905 rs11240349 chr1:205041015 G/A cg21643547 chr1:205240462 TMCC2 -0.4 -7.13 -0.36 6.24e-12 Red blood cell count; LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18765753 chr7:1198926 ZFAND2A -0.62 -12.62 -0.57 3.87e-30 Longevity;Endometriosis; LUSC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3806843 1.000 rs11167609 chr5:140200426 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.77 -0.3 1.79e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2797160 1.000 rs2797160 chr6:126010116 A/G cg05901451 chr6:126070800 HEY2 0.57 8.56 0.42 4.25e-16 Endometrial cancer; LUSC cis rs4253772 0.575 rs9615956 chr22:46749634 C/T cg09491104 chr22:46646882 C22orf40 -0.72 -6.21 -0.32 1.57e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1997103 0.863 rs6956287 chr7:55415107 T/C cg17469321 chr7:55412551 NA 0.68 10.43 0.5 3.23e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs806215 0.950 rs2073561 chr7:127227769 G/C cg25922125 chr7:127225783 GCC1 -0.6 -7.34 -0.37 1.6e-12 Type 2 diabetes; LUSC cis rs10791097 1.000 rs10791098 chr11:130718711 T/G cg12179176 chr11:130786555 SNX19 0.8 13.67 0.6 4.36e-34 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.6 -0.38 3.06e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.35 0.37 1.5e-12 Motion sickness; LUSC cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg23711669 chr6:146136114 FBXO30 0.88 16.24 0.66 4.15e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs7605827 0.930 rs12692275 chr2:15716781 C/T cg19274914 chr2:15703543 NA 0.47 9.09 0.45 9.3e-18 Educational attainment (years of education); LUSC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg25019033 chr10:957182 NA -0.51 -6.42 -0.33 4.67e-10 Eosinophil percentage of granulocytes; LUSC cis rs17685 0.671 rs60303271 chr7:75760008 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs11039798 0.502 rs961863 chr11:48417021 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -7.0 -0.36 1.4e-11 Axial length; LUSC cis rs11190604 1.000 rs10883509 chr10:102296461 C/T cg23241863 chr10:102295624 HIF1AN 0.48 5.85 0.3 1.16e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2908197 0.806 rs12534035 chr7:75980946 G/C cg10167463 chr7:75959203 YWHAG -0.43 -6.41 -0.33 4.87e-10 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs10465746 0.905 rs12127266 chr1:84360767 T/G cg10977910 chr1:84465055 TTLL7 0.43 6.18 0.32 1.92e-9 Obesity-related traits; LUSC cis rs2197308 0.765 rs117216293 chr12:37882982 T/C cg13010199 chr12:38710504 ALG10B -0.61 -9.46 -0.46 5.63e-19 Morning vs. evening chronotype; LUSC cis rs722599 0.748 rs20578 chr14:75367807 C/T cg06637938 chr14:75390232 RPS6KL1 -0.41 -6.01 -0.31 4.93e-9 IgG glycosylation; LUSC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg01475377 chr6:109611718 NA -0.38 -6.69 -0.34 9.16e-11 Reticulocyte fraction of red cells; LUSC cis rs17685 0.623 rs7782808 chr7:75768645 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg25036284 chr2:26402008 FAM59B 0.71 9.71 0.47 8.82e-20 Gut microbiome composition (summer); LUSC cis rs1577917 0.771 rs4419647 chr6:86225739 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.47 0.42 8.02e-16 Response to antipsychotic treatment; LUSC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg21951975 chr1:209979733 IRF6 0.57 6.87 0.35 3.14e-11 Cleft lip with or without cleft palate; LUSC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.89 -0.31 9.44e-9 Lung cancer; LUSC trans rs10411161 0.702 rs8113768 chr19:52383938 C/T cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs4478858 0.746 rs10798832 chr1:31688630 C/G cg00250761 chr1:31883323 NA 0.36 9.37 0.46 1.1e-18 Alcohol dependence; LUSC trans rs8073060 0.963 rs11080353 chr17:33871281 C/T cg19694781 chr19:47549865 TMEM160 0.73 11.26 0.52 3.7e-25 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg19346786 chr7:2764209 NA -0.5 -8.36 -0.42 1.76e-15 Height; LUSC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg18252515 chr7:66147081 NA -1.21 -14.28 -0.62 1.93e-36 Diabetic kidney disease; LUSC cis rs3930017 1.000 rs3930017 chr7:76720582 A/G cg15770687 chr7:76625569 PMS2L11 0.41 5.88 0.31 9.84e-9 Body mass index; LUSC cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.91e-16 Menopause (age at onset); LUSC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg15485101 chr11:133734466 NA 0.43 7.69 0.39 1.63e-13 Childhood ear infection; LUSC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg25319279 chr11:5960081 NA -0.39 -6.15 -0.32 2.17e-9 DNA methylation (variation); LUSC cis rs7312933 0.531 rs2708059 chr12:42851008 C/T cg01256987 chr12:42539512 GXYLT1 0.34 6.35 0.33 7.16e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs1864585 0.520 rs78050613 chr8:10657451 G/A cg26278703 chr11:58910052 FAM111A 0.53 6.0 0.31 5.2e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs941408 0.515 rs1640265 chr19:2784405 C/T cg06609049 chr19:2785107 THOP1 1.12 21.61 0.76 2.01e-65 Total cholesterol levels; LUSC cis rs67072384 1.000 rs7120700 chr11:72444676 A/G cg04827223 chr11:72435913 ARAP1 -0.75 -6.98 -0.36 1.58e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11327383 chr6:34216670 C6orf1 0.47 6.33 0.33 7.67e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1728785 0.748 rs889560 chr16:68605784 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs10788264 0.569 rs7089468 chr10:124019052 T/C cg09507567 chr10:124027408 NA 0.56 9.87 0.48 2.46e-20 Total body bone mineral density; LUSC cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.69 9.51 0.46 4.05e-19 Multiple sclerosis; LUSC cis rs2120019 0.567 rs8029351 chr15:75177237 A/C cg09165964 chr15:75287851 SCAMP5 -0.97 -11.87 -0.54 2.38e-27 Blood trace element (Zn levels); LUSC cis rs3806843 1.000 rs10037757 chr5:140197222 G/T cg03975922 chr5:140080575 ZMAT2 0.31 5.7 0.3 2.69e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg12463550 chr7:65579703 CRCP -0.48 -7.19 -0.37 4.23e-12 Aortic root size; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg01238044 chr22:24384105 GSTT1 -0.67 -10.7 -0.51 3.59e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs911119 0.913 rs67483168 chr20:23581312 T/C cg16589663 chr20:23618590 CST3 0.66 7.76 0.39 1.06e-13 Chronic kidney disease; LUSC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg16049864 chr8:95962084 TP53INP1 -0.47 -7.66 -0.39 2e-13 Type 2 diabetes; LUSC trans rs9650657 0.504 rs10108347 chr8:11033517 G/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.74 -0.39 1.17e-13 Neuroticism; LUSC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg09796270 chr17:17721594 SREBF1 -0.45 -7.94 -0.4 3.14e-14 Total body bone mineral density; LUSC cis rs677665 0.722 rs10746487 chr1:9338689 T/C cg25755851 chr1:9335794 NA -0.61 -9.51 -0.46 3.81e-19 Eosinophil percentage of white cells; LUSC cis rs909341 0.537 rs13041528 chr20:62385446 C/G cg14758556 chr20:62440591 NA -0.43 -5.71 -0.3 2.44e-8 Atopic dermatitis; LUSC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg17971929 chr21:40555470 PSMG1 0.78 13.13 0.58 5.05e-32 Cognitive function; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.5 0.42 6.55e-16 Prudent dietary pattern; LUSC cis rs9467711 0.606 rs9379857 chr6:26367654 G/C cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1595825 0.945 rs6736825 chr2:198854224 C/T cg10547527 chr2:198650123 BOLL -0.49 -5.69 -0.3 2.76e-8 Ulcerative colitis; LUSC cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg19622623 chr12:86230825 RASSF9 -0.45 -6.5 -0.34 2.91e-10 Major depressive disorder; LUSC cis rs763121 1.000 rs1946990 chr22:38912771 C/T cg06022373 chr22:39101656 GTPBP1 -0.75 -12.13 -0.55 2.74e-28 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23125898 chr21:42539633 BACE2 0.4 5.99 0.31 5.49e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8048589 0.559 rs35542345 chr16:12210618 T/C cg02910054 chr16:12241554 SNX29 0.47 6.03 0.31 4.33e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs10791323 0.569 rs1119852 chr11:133743022 C/A cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC cis rs11190604 1.000 rs11190556 chr10:102209223 G/A cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs16854884 0.632 rs35629416 chr3:143748424 C/T cg06585982 chr3:143692056 C3orf58 0.46 7.01 0.36 1.33e-11 Economic and political preferences (feminism/equality); LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.9 -0.31 9.11e-9 Platelet count; LUSC cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg22467129 chr15:76604101 ETFA -0.43 -6.84 -0.35 3.67e-11 Blood metabolite levels; LUSC cis rs13315871 1.000 rs74834816 chr3:58321828 G/A cg12435725 chr3:58293450 RPP14 -0.72 -7.21 -0.37 3.87e-12 Cholesterol, total; LUSC cis rs372883 0.530 rs2832305 chr21:30752964 G/A cg24692254 chr21:30365293 RNF160 0.71 11.0 0.52 3.08e-24 Pancreatic cancer; LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.84 0.39 6.3e-14 Prudent dietary pattern; LUSC cis rs6906287 0.647 rs6936178 chr6:118718242 C/T cg21191810 chr6:118973309 C6orf204 0.34 6.12 0.32 2.64e-9 Electrocardiographic conduction measures; LUSC cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg18105134 chr13:113819100 PROZ -0.66 -10.07 -0.48 5.11e-21 Platelet distribution width; LUSC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.04 0.31 4.11e-9 Hip circumference adjusted for BMI; LUSC cis rs4285028 0.747 rs11916169 chr3:121403211 A/G cg11130432 chr3:121712080 ILDR1 -0.54 -7.83 -0.39 6.54e-14 Multiple sclerosis; LUSC cis rs17270561 0.636 rs4145218 chr6:25746083 G/A cg16482183 chr6:26056742 HIST1H1C 0.65 9.05 0.44 1.21e-17 Iron status biomarkers; LUSC cis rs9309473 0.583 rs35885918 chr2:73612234 T/C cg20560298 chr2:73613845 ALMS1 -0.59 -8.68 -0.43 1.78e-16 Metabolite levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10836402 chr12:31226622 DDX11 0.42 6.11 0.32 2.73e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.44 5.93 0.31 7.41e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg00316803 chr15:76480434 C15orf27 -0.4 -6.93 -0.35 2.23e-11 Blood metabolite levels; LUSC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.39 0.49 4.32e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg08917208 chr2:24149416 ATAD2B 0.53 5.97 0.31 6e-9 Lymphocyte counts; LUSC cis rs714027 0.526 rs73164755 chr22:30590015 A/G cg11564601 chr22:30592435 NA 0.33 5.78 0.3 1.67e-8 Lymphocyte counts; LUSC cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg23711669 chr6:146136114 FBXO30 0.86 15.52 0.65 2.69e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs9902453 1.000 rs9890886 chr17:28391076 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.78 -0.43 8.75e-17 Coffee consumption (cups per day); LUSC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg14895029 chr7:2775587 GNA12 0.4 5.92 0.31 7.92e-9 Height; LUSC trans rs2562456 0.752 rs7258562 chr19:21514564 C/T cg00806126 chr19:22604979 ZNF98 -0.43 -6.16 -0.32 2.07e-9 Pain; LUSC trans rs7680591 1.000 rs1458046 chr4:81199966 C/T cg14075934 chr2:200137014 SATB2 0.35 6.06 0.31 3.61e-9 Male-pattern baldness; LUSC cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg02153584 chr22:29168773 CCDC117 -0.55 -8.3 -0.41 2.62e-15 Lymphocyte counts; LUSC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg10802521 chr3:52805072 NEK4 0.59 9.9 0.48 1.95e-20 Electroencephalogram traits; LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg18758796 chr5:131593413 PDLIM4 -0.43 -6.88 -0.35 2.93e-11 Breast cancer; LUSC cis rs9329289 0.510 rs1155447 chr10:2553240 C/T cg15501526 chr10:2543763 NA 0.53 9.47 0.46 5.12e-19 Age-related hearing impairment; LUSC trans rs73019876 0.869 rs1859093 chr19:22143339 T/G cg16204205 chr18:19753432 GATA6 0.31 5.94 0.31 7.01e-9 Testicular germ cell tumor; LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg15790184 chr11:494944 RNH1 0.42 6.4 0.33 5.37e-10 Systemic lupus erythematosus; LUSC cis rs9796 0.621 rs691702 chr15:41474399 C/G cg18705301 chr15:41695430 NDUFAF1 -0.5 -8.78 -0.43 8.74e-17 Menopause (age at onset); LUSC cis rs7647973 1.000 rs892974 chr3:49398514 C/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.28 0.37 2.47e-12 Menarche (age at onset); LUSC cis rs1728785 0.901 rs8050289 chr16:68566976 T/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg02574844 chr11:5959923 NA -0.45 -6.36 -0.33 6.66e-10 DNA methylation (variation); LUSC cis rs1008375 1.000 rs9291659 chr4:17662360 A/C cg15017067 chr4:17643749 FAM184B 0.35 5.72 0.3 2.41e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3540 0.597 rs1978149 chr15:91036976 A/G cg22089800 chr15:90895588 ZNF774 0.64 9.56 0.46 2.68e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs3942852 0.955 rs1532754 chr11:48115279 A/T cg15704280 chr7:45808275 SEPT13 -0.55 -6.31 -0.33 8.92e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs208520 0.754 rs851594 chr6:66876695 A/G cg07460842 chr6:66804631 NA -1.11 -16.94 -0.68 6.59e-47 Exhaled nitric oxide output; LUSC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.67 -0.3 3.04e-8 Life satisfaction; LUSC cis rs11023332 0.617 rs1879888 chr11:14679247 A/G cg05501817 chr11:14380813 RRAS2 -0.39 -5.92 -0.31 7.96e-9 Adiponectin levels;Vitamin D levels; LUSC cis rs694739 0.930 rs574087 chr11:64102948 A/G cg26898376 chr11:64110657 CCDC88B 0.35 6.75 0.35 6.45e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg00071950 chr4:10020882 SLC2A9 0.49 8.26 0.41 3.51e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2282032 0.527 rs2282033 chr14:90769635 G/T cg04374321 chr14:90722782 PSMC1 -0.41 -5.8 -0.3 1.56e-8 Longevity; LUSC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg06271696 chr7:157225062 NA -0.43 -8.47 -0.42 8.09e-16 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg18225595 chr11:63971243 STIP1 0.5 6.19 0.32 1.73e-9 Mean platelet volume; LUSC cis rs2286885 1.000 rs10733677 chr9:129242209 A/G cg15282417 chr9:129245246 FAM125B 0.34 5.79 0.3 1.65e-8 Intraocular pressure; LUSC trans rs11098499 0.954 rs2306455 chr4:120421969 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg11494091 chr17:61959527 GH2 0.71 15.48 0.65 4.01e-41 Prudent dietary pattern; LUSC cis rs72772090 0.539 rs55773007 chr5:96124918 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.96 -0.36 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs950169 0.922 rs4842946 chr15:84942331 G/A cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC trans rs7726839 0.507 rs72703100 chr5:614291 C/T cg25482853 chr8:67687455 SGK3 1.11 15.6 0.65 1.35e-41 Obesity-related traits; LUSC cis rs7107174 1.000 rs2510032 chr11:77968631 G/C cg02023728 chr11:77925099 USP35 0.52 7.2 0.37 4.11e-12 Testicular germ cell tumor; LUSC cis rs9322817 0.691 rs2499666 chr6:105318576 A/G cg02098413 chr6:105308735 HACE1 0.27 5.8 0.3 1.52e-8 Thyroid stimulating hormone; LUSC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg05425664 chr17:57184151 TRIM37 0.54 8.01 0.4 1.99e-14 Intelligence (multi-trait analysis); LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg10360139 chr7:1886902 MAD1L1 -0.45 -6.96 -0.36 1.83e-11 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg18876405 chr7:65276391 NA -0.55 -8.75 -0.43 1.09e-16 Aortic root size; LUSC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg23985595 chr17:80112537 CCDC57 0.3 5.82 0.3 1.41e-8 Life satisfaction; LUSC cis rs2710642 0.927 rs6705798 chr2:63259881 C/T cg17519650 chr2:63277830 OTX1 0.49 6.73 0.35 7.25e-11 LDL cholesterol levels;LDL cholesterol; LUSC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg24296786 chr1:45957014 TESK2 -0.49 -7.22 -0.37 3.62e-12 Red blood cell count;Reticulocyte count; LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg24675658 chr1:53192096 ZYG11B -0.55 -8.68 -0.43 1.83e-16 Monocyte count; LUSC cis rs6840360 1.000 rs6846114 chr4:152604558 A/G cg22705602 chr4:152727874 NA 0.32 6.58 0.34 1.85e-10 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Bladder cancer; LUSC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg17366294 chr4:99064904 C4orf37 0.6 10.35 0.49 5.73e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.62 0.34 1.41e-10 Menopause (age at onset); LUSC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg18850127 chr7:39170497 POU6F2 0.59 9.68 0.47 1.07e-19 IgG glycosylation; LUSC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg25039879 chr17:56429692 SUPT4H1 0.81 11.08 0.52 1.59e-24 Cognitive test performance; LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg13047869 chr3:10149882 C3orf24 0.65 9.3 0.45 1.96e-18 Alzheimer's disease; LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg24675658 chr1:53192096 ZYG11B 0.81 13.74 0.6 2.28e-34 Monocyte count; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg03790207 chr6:42947109 PEX6 -0.4 -5.93 -0.31 7.39e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11779988 0.545 rs422746 chr8:17784486 C/A cg01800426 chr8:17659068 MTUS1 -0.5 -6.17 -0.32 1.97e-9 Breast cancer; LUSC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg18681998 chr4:17616180 MED28 0.92 18.35 0.71 1.66e-52 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9341835 0.772 rs4710254 chr6:64137609 C/T cg00787780 chr6:64151745 NA -0.34 -5.78 -0.3 1.72e-8 Schizophrenia; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg22907277 chr7:1156413 C7orf50 0.66 7.17 0.37 4.73e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs62400317 0.859 rs56337964 chr6:45039786 G/A cg18551225 chr6:44695536 NA -0.42 -6.84 -0.35 3.83e-11 Total body bone mineral density; LUSC cis rs6696846 0.765 rs11577406 chr1:205065733 G/T cg00857998 chr1:205179979 DSTYK 0.65 10.19 0.49 2.14e-21 Red blood cell count; LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs8092503 1.000 rs7243785 chr18:52475162 C/T cg12377874 chr18:52495404 RAB27B -0.32 -5.84 -0.3 1.26e-8 Childhood body mass index; LUSC cis rs9372498 0.572 rs10484289 chr6:118827836 T/C cg18833306 chr6:118973337 C6orf204 -0.45 -5.73 -0.3 2.28e-8 Diastolic blood pressure; LUSC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg01448562 chr3:133502909 NA 0.47 7.8 0.39 8.01e-14 Iron status biomarkers; LUSC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg16339924 chr4:17578868 LAP3 0.5 7.52 0.38 5.22e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6722750 0.933 rs1370390 chr2:64410193 G/T cg22352474 chr2:64371530 PELI1 0.52 7.76 0.39 1.07e-13 Neuroticism; LUSC cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs7241530 0.662 rs12970916 chr18:75901198 A/T cg14642773 chr18:75888474 NA -0.4 -6.06 -0.31 3.72e-9 Educational attainment (years of education); LUSC cis rs7084921 0.608 rs12775433 chr10:101834092 C/T cg02250046 chr10:101825185 CPN1 -0.33 -6.02 -0.31 4.59e-9 Bone mineral density; LUSC cis rs709400 0.628 rs2010281 chr14:103862322 G/A cg12935359 chr14:103987150 CKB -0.55 -8.44 -0.42 9.86e-16 Body mass index; LUSC cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs2294693 0.891 rs9369256 chr6:40998344 G/C cg14769373 chr6:40998127 UNC5CL -0.55 -7.89 -0.4 4.23e-14 Gastric cancer;Non-cardia gastric cancer; LUSC trans rs73019876 0.869 rs7247121 chr19:22161490 T/C cg16204205 chr18:19753432 GATA6 0.31 5.96 0.31 6.42e-9 Testicular germ cell tumor; LUSC cis rs7666738 0.546 rs28590002 chr4:98722642 C/T cg05340658 chr4:99064831 C4orf37 0.59 8.86 0.44 4.91e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs981844 0.848 rs72731652 chr4:154641123 A/T cg14289246 chr4:154710475 SFRP2 0.46 5.88 0.31 9.88e-9 Response to statins (LDL cholesterol change); LUSC cis rs6120849 0.754 rs7268266 chr20:33581889 T/C cg24642439 chr20:33292090 TP53INP2 0.62 6.78 0.35 5.58e-11 Protein C levels; LUSC cis rs208520 0.661 rs4710566 chr6:66848538 G/A cg07460842 chr6:66804631 NA -1.13 -17.69 -0.7 6.9e-50 Exhaled nitric oxide output; LUSC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg20203395 chr5:56204925 C5orf35 -0.45 -6.5 -0.34 2.95e-10 Coronary artery disease; LUSC cis rs11864453 0.611 rs1050361 chr16:72130203 C/G cg01557791 chr16:72042693 DHODH -0.43 -6.53 -0.34 2.42e-10 Fibrinogen levels; LUSC cis rs9527 0.590 rs11191547 chr10:104843148 C/T cg04362960 chr10:104952993 NT5C2 0.63 9.69 0.47 1.01e-19 Arsenic metabolism; LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.57 -0.5 1.04e-22 Alzheimer's disease; LUSC cis rs3741151 0.686 rs1002127 chr11:73103835 G/C cg17517138 chr11:73019481 ARHGEF17 0.9 8.31 0.41 2.42e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs724744 0.742 rs1205935 chr6:22358129 A/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs10857712 0.950 rs11101744 chr10:135226041 G/C cg01444801 chr10:135216882 MTG1 -0.5 -6.54 -0.34 2.27e-10 Systemic lupus erythematosus; LUSC cis rs6754311 0.593 rs2034276 chr2:136422171 A/T cg07169764 chr2:136633963 MCM6 0.55 7.3 0.37 2.16e-12 Mosquito bite size; LUSC cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg08999081 chr20:33150536 PIGU 0.51 10.18 0.49 2.2e-21 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg23758822 chr17:41437982 NA 1.04 19.54 0.73 3.11e-57 Menopause (age at onset); LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg18402987 chr7:1209562 NA 0.67 7.08 0.36 8.56e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11165623 0.792 rs6701031 chr1:96975515 C/T cg10631902 chr5:14652156 NA -0.43 -6.67 -0.34 1.09e-10 Hip circumference;Waist circumference; LUSC cis rs3020736 0.500 rs9620026 chr22:42498578 C/T cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs12195417 0.758 rs4706996 chr6:84135539 C/T cg08257003 chr6:84140564 ME1 0.37 9.11 0.45 7.7e-18 Schizophrenia; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg06873352 chr17:61820015 STRADA -0.69 -12.42 -0.56 2.3e-29 Prudent dietary pattern; LUSC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.6 -5.66 -0.3 3.24e-8 Cerebrospinal P-tau181p levels; LUSC cis rs2976388 1.000 rs2976398 chr8:143764879 G/C cg17252645 chr8:143867129 LY6D -0.37 -6.47 -0.33 3.45e-10 Urinary tract infection frequency; LUSC cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg00677455 chr12:58241039 CTDSP2 0.39 5.88 0.31 9.81e-9 Multiple sclerosis; LUSC cis rs4589502 0.841 rs75991095 chr15:67123224 C/G cg09911534 chr15:67153556 NA -0.69 -6.82 -0.35 4.27e-11 Lung cancer (smoking interaction); LUSC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg21918786 chr6:109611834 NA -0.37 -6.24 -0.32 1.32e-9 Reticulocyte fraction of red cells; LUSC cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg24692254 chr21:30365293 RNF160 -0.54 -8.01 -0.4 1.87e-14 Dental caries; LUSC cis rs11098499 0.866 rs72676074 chr4:120359841 A/C cg09307838 chr4:120376055 NA 0.75 10.73 0.51 2.87e-23 Corneal astigmatism; LUSC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg22166914 chr1:53195759 ZYG11B -0.67 -11.6 -0.54 2.25e-26 Monocyte count; LUSC trans rs804280 0.518 rs34266352 chr8:11791462 G/A cg14343924 chr8:8086146 FLJ10661 0.44 6.11 0.32 2.74e-9 Myopia (pathological); LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg00431813 chr7:1051703 C7orf50 -0.37 -5.69 -0.3 2.77e-8 Longevity;Endometriosis; LUSC cis rs4819052 0.679 rs2236450 chr21:46702553 T/C cg11663144 chr21:46675770 NA -0.34 -6.03 -0.31 4.33e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12891047 0.804 rs17783094 chr14:68282920 G/A cg20999565 chr14:68265668 ZFYVE26 0.38 5.79 0.3 1.58e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg12615879 chr12:58013172 SLC26A10 -0.29 -5.94 -0.31 7.18e-9 Multiple sclerosis; LUSC trans rs17685 0.712 rs7794454 chr7:75776010 A/G cg19862616 chr7:65841803 NCRNA00174 -1.12 -19.31 -0.73 2.52e-56 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7824557 0.751 rs2099456 chr8:11127001 A/C cg27411982 chr8:10470053 RP1L1 0.36 5.82 0.3 1.39e-8 Retinal vascular caliber; LUSC cis rs10276381 0.786 rs740261 chr7:28241276 A/G cg23620719 chr7:28220237 JAZF1 0.67 6.85 0.35 3.65e-11 Crohn's disease; LUSC cis rs11997175 0.656 rs2350007 chr8:33585353 C/G ch.8.33884649F chr8:33765107 NA 0.38 6.01 0.31 4.96e-9 Body mass index; LUSC cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg03281426 chr2:240109471 HDAC4 0.62 11.41 0.53 1.11e-25 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs921968 0.565 rs7599945 chr2:219641528 G/T cg02176678 chr2:219576539 TTLL4 -0.56 -9.81 -0.47 4.09e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs977987 0.806 rs35263058 chr16:75391937 T/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.63 -0.34 1.36e-10 Dupuytren's disease; LUSC cis rs3008870 0.785 rs10889651 chr1:67463513 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.75 -12.17 -0.55 1.86e-28 Lymphocyte percentage of white cells; LUSC cis rs17095355 1.000 rs17126877 chr10:111672786 C/T cg00817464 chr10:111662876 XPNPEP1 -0.64 -7.47 -0.38 6.94e-13 Biliary atresia; LUSC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg04850211 chr1:228464232 OBSCN -0.33 -6.15 -0.32 2.27e-9 Diastolic blood pressure; LUSC cis rs66887589 0.616 rs6843509 chr4:120220196 G/A cg13609457 chr4:120235615 NA 0.39 5.93 0.31 7.36e-9 Diastolic blood pressure; LUSC cis rs12220238 1.000 rs11000931 chr10:75984800 A/C cg19889307 chr10:75911429 ADK;AP3M1 -0.67 -7.61 -0.38 2.81e-13 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7937682 0.889 rs1940529 chr11:111498523 G/C cg22437258 chr11:111473054 SIK2 0.52 7.05 0.36 1.03e-11 Primary sclerosing cholangitis; LUSC cis rs4285028 0.747 rs9824235 chr3:121432177 G/T cg11130432 chr3:121712080 ILDR1 -0.53 -7.79 -0.39 8.68e-14 Multiple sclerosis; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg15073462 chr3:172469117 NA 0.45 6.13 0.32 2.5e-9 Neuroticism; LUSC cis rs1775715 0.737 rs2778672 chr10:32122419 T/C cg04359828 chr10:32216031 ARHGAP12 0.4 6.75 0.35 6.56e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6076065 0.630 rs2424559 chr20:23430519 A/G cg11657817 chr20:23433608 CST11 0.51 10.71 0.51 3.39e-23 Facial morphology (factor 15, philtrum width); LUSC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg10295955 chr4:187884368 NA -1.08 -25.56 -0.81 1.33e-80 Lobe attachment (rater-scored or self-reported); LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg11766577 chr21:47581405 C21orf56 -0.57 -8.71 -0.43 1.48e-16 Testicular germ cell tumor; LUSC cis rs2458413 0.543 rs2514658 chr8:105337871 G/A cg04554929 chr8:105342491 NA -0.38 -6.72 -0.35 7.73e-11 Paget's disease; LUSC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg19346786 chr7:2764209 NA -0.4 -6.74 -0.35 6.88e-11 Height; LUSC cis rs887829 0.569 rs2008595 chr2:234637192 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -7.07 -0.36 9.06e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs2677744 0.626 rs12905855 chr15:91498429 G/C cg23684204 chr15:91497937 RCCD1 0.56 7.68 0.39 1.8e-13 Attention deficit hyperactivity disorder; LUSC cis rs513349 0.964 rs210141 chr6:33546825 T/C cg24505687 chr6:33548425 BAK1 0.36 6.04 0.31 4.04e-9 Platelet count; LUSC cis rs870825 0.746 rs1107908 chr4:185620113 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs2404602 0.684 rs1011084 chr15:77007480 C/G cg23625390 chr15:77176239 SCAPER -0.67 -10.04 -0.48 6.78e-21 Blood metabolite levels; LUSC cis rs7772486 0.902 rs2748500 chr6:146314852 C/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.59 -0.34 1.67e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.580 rs12509234 chr4:120319434 T/C cg09307838 chr4:120376055 NA 0.79 11.36 0.53 1.63e-25 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12528394 chr19:59056208 TRIM28 -0.41 -6.25 -0.32 1.27e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs208520 0.690 rs2208442 chr6:66867004 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.94 -0.68 7.04e-47 Exhaled nitric oxide output; LUSC cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 8.92 0.44 3.05e-17 Monocyte percentage of white cells; LUSC cis rs8141529 0.778 rs763073 chr22:29215542 G/A cg15103426 chr22:29168792 CCDC117 0.58 7.86 0.4 5.24e-14 Lymphocyte counts; LUSC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg18758796 chr5:131593413 PDLIM4 0.37 6.17 0.32 2.02e-9 Breast cancer;Mosquito bite size; LUSC cis rs1609391 0.543 rs6761993 chr3:136625902 C/T cg15507776 chr3:136538369 TMEM22 0.5 8.25 0.41 3.79e-15 Neuroticism; LUSC trans rs976337 0.872 rs4753661 chr11:95000894 A/G cg04211581 chr6:152011656 ESR1 0.33 6.16 0.32 2.04e-9 Positive affect; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.95 0.55 1.17e-27 Prudent dietary pattern; LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg14884256 chr3:50374861 RASSF1 -0.39 -5.99 -0.31 5.44e-9 QT interval (ambient particulate matter interaction); LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs208515 0.525 rs10944859 chr6:66665197 A/G cg07460842 chr6:66804631 NA 1.04 14.11 0.61 9.12e-36 Exhaled nitric oxide levels; LUSC cis rs62400317 0.731 rs72867436 chr6:44975488 T/G cg20913747 chr6:44695427 NA -0.46 -7.23 -0.37 3.41e-12 Total body bone mineral density; LUSC cis rs1322512 0.874 rs2758804 chr6:152956289 T/A cg27316956 chr6:152958899 SYNE1 -0.37 -6.22 -0.32 1.49e-9 Tonometry; LUSC cis rs17685 0.587 rs1623759 chr7:75724679 A/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.83 -0.39 6.5e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg10802521 chr3:52805072 NEK4 -0.57 -9.3 -0.45 1.87e-18 Electroencephalogram traits; LUSC cis rs6489882 0.867 rs2384073 chr12:113367595 A/G cg20102336 chr12:113376681 OAS3 -0.4 -5.74 -0.3 2.17e-8 Chronic lymphocytic leukemia; LUSC cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg26384229 chr12:38710491 ALG10B 0.95 17.72 0.7 5.52e-50 Heart rate; LUSC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg27170947 chr2:26402098 FAM59B -0.64 -9.5 -0.46 4.26e-19 Gut microbiome composition (summer); LUSC cis rs16976116 0.951 rs8043029 chr15:55486011 C/G cg11288833 chr15:55489084 RSL24D1 0.54 6.55 0.34 2.14e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2742417 1.000 rs2673025 chr3:45760483 A/G cg18779283 chr3:45636154 LIMD1 -0.33 -5.76 -0.3 1.91e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs372883 0.564 rs766928 chr21:30753606 A/G cg24692254 chr21:30365293 RNF160 0.73 11.33 0.53 2.05e-25 Pancreatic cancer; LUSC cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg07148914 chr20:33460835 GGT7 0.55 8.35 0.42 1.79e-15 Height; LUSC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg20684491 chr1:25596433 NA 0.4 6.28 0.32 1.07e-9 Plateletcrit;Mean corpuscular volume; LUSC trans rs7937682 0.855 rs490897 chr11:111487914 A/G cg18187862 chr3:45730750 SACM1L 0.52 6.82 0.35 4.21e-11 Primary sclerosing cholangitis; LUSC cis rs950027 0.620 rs1426932 chr15:45687256 T/C cg04036182 chr15:45458818 NA 0.35 5.79 0.3 1.63e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg05025164 chr4:1340916 KIAA1530 0.41 6.19 0.32 1.71e-9 Obesity-related traits; LUSC cis rs208520 0.874 rs208481 chr6:66922636 A/G cg07460842 chr6:66804631 NA -1.01 -14.4 -0.62 6.44e-37 Exhaled nitric oxide output; LUSC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg03354898 chr7:1950403 MAD1L1 -0.3 -5.68 -0.3 2.97e-8 Bipolar disorder and schizophrenia; LUSC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg09365446 chr1:150670422 GOLPH3L -0.43 -6.42 -0.33 4.6e-10 Tonsillectomy; LUSC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg06618935 chr21:46677482 NA 0.35 6.97 0.36 1.69e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs17685 0.587 rs1623759 chr7:75724679 A/T cg19862616 chr7:65841803 NCRNA00174 1.13 19.75 0.73 4.68e-58 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs61931739 0.517 rs11052980 chr12:34036036 T/C cg26384229 chr12:38710491 ALG10B 0.67 10.61 0.5 7.65e-23 Morning vs. evening chronotype; LUSC cis rs4713675 0.584 rs749847 chr6:33665001 G/C cg14003231 chr6:33640908 ITPR3 0.31 6.03 0.31 4.31e-9 Plateletcrit; LUSC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg24110177 chr3:50126178 RBM5 0.56 9.25 0.45 2.66e-18 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.8 -0.7 2.49e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs4073416 0.542 rs2898814 chr14:66023961 T/C cg03016385 chr14:66212404 NA -0.38 -5.7 -0.3 2.59e-8 N-glycan levels; LUSC cis rs1775715 0.835 rs11008701 chr10:32241096 A/G cg04359828 chr10:32216031 ARHGAP12 0.38 6.4 0.33 5.38e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1979679 0.573 rs7315906 chr12:28728545 A/C cg13890972 chr12:28721907 NA -0.4 -5.85 -0.3 1.16e-8 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs4474465 0.646 rs7936011 chr11:78275931 G/T cg27205649 chr11:78285834 NARS2 0.55 6.78 0.35 5.41e-11 Alzheimer's disease (survival time); LUSC cis rs4862307 0.688 rs6552743 chr4:184990516 C/G cg06737308 chr4:185021514 ENPP6 0.43 6.46 0.33 3.66e-10 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg14530993 chr4:882597 GAK 0.73 7.42 0.38 9.98e-13 Intelligence (multi-trait analysis); LUSC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg08680598 chr22:49984980 NA -0.34 -6.36 -0.33 6.69e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12597458 0.763 rs3213422 chr16:72042682 A/C cg01557791 chr16:72042693 DHODH 0.62 9.77 0.47 5.35e-20 Prostate cancer; LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg08888203 chr3:10149979 C3orf24 0.67 9.61 0.47 1.8e-19 Alzheimer's disease; LUSC cis rs9329221 0.662 rs12541491 chr8:10250048 C/T cg21775007 chr8:11205619 TDH 0.44 5.79 0.3 1.62e-8 Neuroticism; LUSC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg03240473 chr21:43526662 UMODL1;C21orf128 -0.57 -9.32 -0.45 1.58e-18 IgG glycosylation; LUSC cis rs35110281 0.501 rs162378 chr21:44925905 A/G cg04455712 chr21:45112962 RRP1B -0.41 -7.19 -0.37 4.2e-12 Mean corpuscular volume; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14331148 chr19:47551893 TMEM160 -0.42 -7.14 -0.36 5.78e-12 Electrocardiographic conduction measures; LUSC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs9788682 0.747 rs8043009 chr15:78908154 G/C cg06917634 chr15:78832804 PSMA4 -0.49 -6.51 -0.34 2.74e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2298450 0.717 rs2835328 chr21:37622915 A/C cg02919814 chr21:37666008 DOPEY2 -0.48 -6.63 -0.34 1.32e-10 Schizophrenia; LUSC cis rs9311676 0.656 rs11712213 chr3:58384995 G/A cg26110898 chr3:58419937 PDHB 0.4 6.49 0.33 3.05e-10 Systemic lupus erythematosus; LUSC cis rs3781663 0.553 rs875108 chr11:70004695 G/A cg06393558 chr11:69982916 ANO1 -0.41 -6.1 -0.32 2.9e-9 Survival in rectal cancer; LUSC cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg25427524 chr10:38739819 LOC399744 -0.58 -10.46 -0.5 2.46e-22 Extrinsic epigenetic age acceleration; LUSC cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg13010199 chr12:38710504 ALG10B 0.66 10.18 0.49 2.16e-21 Bladder cancer; LUSC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg09509183 chr1:209979624 IRF6 0.52 6.21 0.32 1.61e-9 Cleft lip with or without cleft palate; LUSC cis rs599083 0.829 rs23691 chr11:68178668 G/A cg01657329 chr11:68192670 LRP5 0.5 7.5 0.38 5.88e-13 Bone mineral density (spine); LUSC trans rs12458462 0.851 rs3859317 chr18:77443093 A/C cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.8 -0.35 4.8e-11 Monocyte count; LUSC cis rs189218934 1 rs189218934 chr15:78903987 T/C cg06917634 chr15:78832804 PSMA4 0.51 6.49 0.33 3.03e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs8031584 0.578 rs1088473 chr15:31139298 A/G cg14298792 chr15:30685198 CHRFAM7A 0.69 8.93 0.44 2.94e-17 Huntington's disease progression; LUSC cis rs2677744 0.626 rs12915155 chr15:91490894 G/T cg23684204 chr15:91497937 RCCD1 0.53 7.37 0.37 1.32e-12 Attention deficit hyperactivity disorder; LUSC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg21770322 chr7:97807741 LMTK2 0.4 7.03 0.36 1.14e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 0.508 rs6902119 chr6:167505791 T/C cg07741184 chr6:167504864 NA 0.39 6.9 0.35 2.56e-11 Crohn's disease; LUSC cis rs4478858 0.684 rs7549245 chr1:31752187 A/G cg00250761 chr1:31883323 NA -0.33 -7.95 -0.4 2.9e-14 Alcohol dependence; LUSC cis rs9653442 0.527 rs11123812 chr2:100761548 T/C cg07810366 chr2:100720526 AFF3 -0.45 -7.75 -0.39 1.13e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7582180 0.663 rs2309800 chr2:100992086 C/T cg08017756 chr2:100939284 LONRF2 -0.41 -7.56 -0.38 3.89e-13 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg07741184 chr6:167504864 NA 0.43 7.69 0.39 1.68e-13 Crohn's disease; LUSC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg18252515 chr7:66147081 NA 1.23 14.12 0.61 8.1e-36 Diabetic kidney disease; LUSC cis rs870825 0.616 rs4594761 chr4:185643002 A/C cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs1733410 0.504 rs11181874 chr12:37912890 C/A cg13010199 chr12:38710504 ALG10B -0.6 -9.33 -0.45 1.56e-18 Morning vs. evening chronotype; LUSC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.46 -6.64 -0.34 1.27e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7107174 0.901 rs10899500 chr11:78125246 A/G cg02023728 chr11:77925099 USP35 0.48 6.76 0.35 6.29e-11 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.49 -0.42 6.66e-16 Lung cancer; LUSC cis rs4805272 0.512 rs8106166 chr19:29339578 A/G cg12667521 chr19:29218732 NA -0.56 -6.86 -0.35 3.39e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg03354898 chr7:1950403 MAD1L1 -0.37 -7.27 -0.37 2.64e-12 Bipolar disorder and schizophrenia; LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg12016809 chr21:47604291 C21orf56 0.43 6.45 0.33 4.02e-10 Testicular germ cell tumor; LUSC cis rs981844 0.712 rs4525952 chr4:154746606 G/T cg14289246 chr4:154710475 SFRP2 0.47 6.02 0.31 4.58e-9 Response to statins (LDL cholesterol change); LUSC cis rs4073582 0.595 rs474005 chr11:66033301 C/T cg14036092 chr11:66035641 RAB1B 0.44 6.34 0.33 7.65e-10 Gout; LUSC cis rs35146811 0.735 rs1637001 chr7:99808151 G/A cg13334819 chr7:99746414 C7orf59 0.52 6.96 0.36 1.76e-11 Coronary artery disease; LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg16362232 chr11:430036 ANO9 -0.61 -8.0 -0.4 2.02e-14 Body mass index; LUSC trans rs1256061 0.874 rs7146434 chr14:64726503 A/G cg07874507 chr10:24503148 KIAA1217 0.36 6.21 0.32 1.59e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg03929089 chr4:120376271 NA -0.55 -6.64 -0.34 1.28e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs12908161 1.000 rs12903134 chr15:85337699 T/A cg12863693 chr15:85201151 NMB 0.39 8.05 0.4 1.49e-14 Schizophrenia; LUSC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg06637938 chr14:75390232 RPS6KL1 0.54 8.61 0.43 2.91e-16 Height; LUSC cis rs8028313 0.630 rs28418298 chr15:67935745 C/T cg08079166 chr15:68083412 MAP2K5 0.36 6.2 0.32 1.7e-9 Obesity; LUSC cis rs11587400 0.572 rs2268697 chr1:115227493 A/G cg12756093 chr1:115239321 AMPD1 0.46 7.1 0.36 7.33e-12 Autism; LUSC cis rs919433 0.519 rs700658 chr2:198655007 A/T cg00792783 chr2:198669748 PLCL1 0.41 5.68 0.3 2.89e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg27286337 chr10:134555280 INPP5A 0.99 21.45 0.76 9e-65 Migraine; LUSC cis rs7804356 0.954 rs10225924 chr7:26839954 C/T cg03456212 chr7:26904342 SKAP2 -0.55 -6.47 -0.33 3.54e-10 Type 1 diabetes; LUSC cis rs2629540 0.765 rs7097254 chr10:126512248 A/C cg08799069 chr10:126477246 METTL10 -0.56 -8.73 -0.43 1.23e-16 Cocaine dependence; LUSC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg07701084 chr6:150067640 NUP43 0.52 7.42 0.38 9.6e-13 Lung cancer; LUSC cis rs4493873 0.731 rs34213675 chr8:92043378 C/T cg16814680 chr8:91681699 NA 0.42 5.79 0.3 1.58e-8 Migraine - clinic-based; LUSC cis rs11148252 0.740 rs9536052 chr13:52960709 C/G cg00495681 chr13:53174319 NA -0.5 -7.74 -0.39 1.2e-13 Lewy body disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19617932 chr12:1703704 FBXL14 -0.45 -6.78 -0.35 5.46e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs34638657 0.529 rs2059276 chr16:82223123 A/T cg09439754 chr16:82129088 HSD17B2 -0.33 -5.95 -0.31 6.96e-9 Lung adenocarcinoma; LUSC cis rs12474201 0.925 rs17822294 chr2:46960004 G/A cg06386533 chr2:46925753 SOCS5 0.73 10.89 0.51 8e-24 Height; LUSC cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs7193541 0.662 rs8052367 chr16:74658867 G/A cg01733217 chr16:74700730 RFWD3 1.0 22.88 0.78 2.26e-70 Multiple myeloma; LUSC cis rs96067 0.772 rs6664471 chr1:36606757 A/G cg24686825 chr1:36642396 MAP7D1 -0.49 -6.63 -0.34 1.35e-10 Corneal structure; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.66 10.84 0.51 1.19e-23 Lymphocyte counts; LUSC trans rs7939886 0.844 rs17150088 chr11:55894862 T/G cg03929089 chr4:120376271 NA 0.74 6.11 0.32 2.7e-9 Myopia (pathological); LUSC cis rs9549367 0.789 rs2316442 chr13:113877487 C/T cg00898013 chr13:113819073 PROZ -0.59 -8.47 -0.42 7.84e-16 Platelet distribution width; LUSC cis rs1577917 0.771 rs9294337 chr6:86248460 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 10.78 0.51 1.92e-23 Response to antipsychotic treatment; LUSC cis rs35883536 0.626 rs10783140 chr1:101042083 A/G cg06223162 chr1:101003688 GPR88 -0.48 -9.03 -0.44 1.4e-17 Monocyte count; LUSC trans rs17783634 0.509 rs11775489 chr8:11036843 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.98 -0.36 1.63e-11 Subjective well-being; LUSC cis rs477692 1.000 rs477692 chr10:131426022 T/C cg05714579 chr10:131428358 MGMT 0.53 7.87 0.4 5.09e-14 Response to temozolomide; LUSC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.83 11.19 0.52 6.51e-25 Schizophrenia; LUSC cis rs9815354 0.723 rs77572508 chr3:41938044 C/A cg03022575 chr3:42003672 ULK4 0.83 8.64 0.43 2.32e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs17125944 0.505 rs3783447 chr14:53191647 G/A cg13660082 chr14:53194042 PSMC6 -0.76 -6.76 -0.35 6.03e-11 Alzheimer's disease (late onset); LUSC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg11663144 chr21:46675770 NA -0.41 -7.08 -0.36 8.51e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg15704280 chr7:45808275 SEPT13 -0.46 -6.37 -0.33 6.38e-10 Height; LUSC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.42 0.42 1.11e-15 Height; LUSC cis rs6459804 0.967 rs10233396 chr7:157512290 C/T cg05731713 chr7:157510257 PTPRN2 0.46 8.99 0.44 1.81e-17 Bipolar disorder and schizophrenia; LUSC cis rs12410462 0.581 rs12402691 chr1:227543693 G/A cg23173402 chr1:227635558 NA 0.56 6.4 0.33 5.15e-10 Major depressive disorder; LUSC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg13114125 chr14:105738426 BRF1 -0.93 -16.39 -0.67 1.07e-44 Mean platelet volume;Platelet distribution width; LUSC cis rs8017423 0.647 rs1958346 chr14:90824011 G/T cg04374321 chr14:90722782 PSMC1 -0.42 -6.39 -0.33 5.65e-10 Mortality in heart failure; LUSC cis rs13089785 1.000 rs13081955 chr3:123600144 A/G cg19611163 chr3:123411211 MYLK 0.35 5.86 0.31 1.11e-8 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.705 rs4646087 chr1:15822404 A/G cg17385448 chr1:15911702 AGMAT 0.37 5.81 0.3 1.45e-8 Systolic blood pressure; LUSC cis rs4499344 0.526 rs8111902 chr19:33032243 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.8 -10.68 -0.5 4.31e-23 Mean platelet volume; LUSC cis rs8044995 0.563 rs3785116 chr16:68372730 G/A cg09835421 chr16:68378352 PRMT7 -0.82 -8.7 -0.43 1.52e-16 Schizophrenia; LUSC cis rs79057730 0.684 rs6955004 chr7:790792 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.71 6.86 0.35 3.34e-11 Initial pursuit acceleration; LUSC cis rs4076764 0.846 rs7525724 chr1:163426372 G/A cg06092702 chr1:163392909 NA -0.42 -7.16 -0.36 5.1e-12 Motion sickness; LUSC trans rs11165623 0.564 rs6593611 chr1:97001996 T/C cg10631902 chr5:14652156 NA -0.42 -6.22 -0.32 1.52e-9 Hip circumference;Waist circumference; LUSC cis rs360798 0.532 rs7573756 chr2:62990637 G/A cg17519650 chr2:63277830 OTX1 -0.52 -7.22 -0.37 3.63e-12 Coronary artery disease; LUSC cis rs12310956 0.532 rs1352211 chr12:33983132 G/A cg06521331 chr12:34319734 NA -0.47 -7.55 -0.38 4.09e-13 Morning vs. evening chronotype; LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg14004847 chr7:1930337 MAD1L1 -0.53 -8.16 -0.41 7e-15 Bipolar disorder and schizophrenia; LUSC cis rs7786877 0.521 rs4729607 chr7:100326744 T/A cg16850897 chr7:100343110 ZAN -0.56 -7.93 -0.4 3.36e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg06544989 chr22:39130855 UNC84B 0.33 5.87 0.31 1.06e-8 Menopause (age at onset); LUSC cis rs9399401 0.710 rs12190271 chr6:142681409 A/G cg04461802 chr6:142623433 GPR126 -0.44 -5.74 -0.3 2.15e-8 Chronic obstructive pulmonary disease; LUSC cis rs5770917 1.000 rs2073604 chr22:51008925 G/A cg00270625 chr22:51017019 CPT1B;CHKB-CPT1B -0.62 -5.74 -0.3 2.15e-8 Narcolepsy; LUSC cis rs9534288 0.830 rs1409435 chr13:46631660 G/A cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg12463550 chr7:65579703 CRCP 0.43 6.22 0.32 1.51e-9 Aortic root size; LUSC cis rs1595825 0.735 rs2228135 chr2:198950029 A/G cg00982548 chr2:198649783 BOLL -0.54 -6.58 -0.34 1.86e-10 Ulcerative colitis; LUSC cis rs6066835 0.850 rs3827042 chr20:47319307 G/A cg18078177 chr20:47281410 PREX1 0.71 5.96 0.31 6.29e-9 Multiple myeloma; LUSC trans rs7824557 0.564 rs11781637 chr8:11214972 C/T cg15556689 chr8:8085844 FLJ10661 -0.58 -8.96 -0.44 2.27e-17 Retinal vascular caliber; LUSC cis rs9326248 0.539 rs10892058 chr11:116876621 C/T cg26566898 chr11:117069891 TAGLN 0.33 6.39 0.33 5.73e-10 Blood protein levels; LUSC cis rs3126085 0.935 rs11588174 chr1:152175970 C/T cg03465714 chr1:152285911 FLG 0.42 5.72 0.3 2.42e-8 Atopic dermatitis; LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 16.38 0.67 1.1e-44 Platelet count; LUSC cis rs4926611 0.729 rs17382457 chr1:54071428 A/G cg08927728 chr1:54059983 GLIS1 -0.27 -5.75 -0.3 1.98e-8 Hand grip strength; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.96 -20.98 -0.75 5.98e-63 Prudent dietary pattern; LUSC cis rs6582630 0.555 rs61932279 chr12:38349096 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.97 -0.4 2.48e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg06481639 chr22:41940642 POLR3H 0.49 5.81 0.3 1.48e-8 Vitiligo; LUSC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg20503657 chr10:835505 NA 0.85 12.05 0.55 5.19e-28 Eosinophil percentage of granulocytes; LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg14015726 chr22:40807049 MKL1 0.38 6.09 0.32 3.1e-9 QT interval (ambient particulate matter interaction); LUSC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg15704280 chr7:45808275 SEPT13 -1.08 -19.9 -0.74 1.14e-58 Coronary artery disease; LUSC cis rs262150 0.625 rs55882200 chr7:158769280 G/C cg19418458 chr7:158789849 NA 0.57 7.01 0.36 1.32e-11 Facial morphology (factor 20); LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg16647868 chr5:131706066 SLC22A5 -0.38 -5.7 -0.3 2.64e-8 Breast cancer; LUSC cis rs983392 0.679 rs6591559 chr11:60025565 C/T cg24026212 chr11:59952134 MS4A6A -0.37 -6.37 -0.33 6.38e-10 Alzheimer's disease (late onset); LUSC cis rs1008375 0.900 rs6812675 chr4:17597549 A/G cg18681998 chr4:17616180 MED28 0.84 14.53 0.62 2.14e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg26769984 chr7:1090371 C7orf50 0.56 7.34 0.37 1.67e-12 Bronchopulmonary dysplasia; LUSC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg17340268 chr14:105411764 AHNAK2 -0.39 -6.3 -0.33 9.59e-10 Rheumatoid arthritis; LUSC cis rs2692947 0.644 rs1168970 chr2:96816606 C/T cg22654517 chr2:96458247 NA 0.32 5.82 0.3 1.4e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6456156 0.586 rs4710176 chr6:167491639 T/C cg06454157 chr6:167490870 NA -0.28 -6.37 -0.33 6.26e-10 Primary biliary cholangitis; LUSC cis rs7267979 1.000 rs6107047 chr20:25442097 G/A cg03522245 chr20:25566470 NINL 0.35 5.66 0.3 3.26e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg06618935 chr21:46677482 NA -0.39 -7.99 -0.4 2.22e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10761482 0.668 rs1002710 chr10:62122120 C/T cg18175470 chr10:62150864 ANK3 -0.41 -6.19 -0.32 1.75e-9 Schizophrenia; LUSC cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs983392 0.679 rs1026254 chr11:60030457 A/G cg02771260 chr11:59836817 MS4A3 0.38 6.24 0.32 1.3e-9 Alzheimer's disease (late onset); LUSC cis rs7107174 1.000 rs4492844 chr11:78026516 A/G cg02023728 chr11:77925099 USP35 0.47 6.73 0.35 7.32e-11 Testicular germ cell tumor; LUSC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg15839431 chr19:19639596 YJEFN3 -0.6 -6.9 -0.35 2.58e-11 Bipolar disorder; LUSC cis rs7267979 1.000 rs2387880 chr20:25377787 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg05457628 chr5:178986728 RUFY1 0.57 9.77 0.47 5.57e-20 Lung cancer; LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg04267008 chr7:1944627 MAD1L1 -0.55 -8.26 -0.41 3.56e-15 Bipolar disorder and schizophrenia; LUSC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg17264618 chr3:40429014 ENTPD3 0.29 6.07 0.32 3.46e-9 Renal cell carcinoma; LUSC cis rs7786877 0.521 rs4729606 chr7:100321790 T/C cg00334542 chr7:100209784 MOSPD3 -0.48 -5.75 -0.3 2.05e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg19717773 chr7:2847554 GNA12 -0.4 -6.39 -0.33 5.47e-10 Height; LUSC cis rs68170813 0.559 rs114221457 chr7:107019913 C/G cg02696742 chr7:106810147 HBP1 -0.64 -9.4 -0.46 8.95e-19 Coronary artery disease; LUSC cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg04034577 chr2:241836375 C2orf54 -0.49 -8.92 -0.44 3.11e-17 Urinary metabolites; LUSC cis rs6547741 0.935 rs4260197 chr2:27794150 C/G cg27432699 chr2:27873401 GPN1 -0.83 -15.97 -0.66 4.84e-43 Oral cavity cancer; LUSC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg05347473 chr6:146136440 FBXO30 0.57 9.79 0.47 4.77e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs193541 0.642 rs42538 chr5:122292352 A/T cg19077854 chr5:122220652 SNX24 0.39 8.38 0.42 1.48e-15 Glucose homeostasis traits; LUSC trans rs637571 0.522 rs503524 chr11:65751764 C/T cg17712092 chr4:129076599 LARP1B 0.74 11.25 0.52 4.02e-25 Eosinophil percentage of white cells; LUSC cis rs36093844 0.800 rs78356210 chr11:85581267 G/A cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs4499344 0.730 rs614361 chr19:33106387 C/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.93 0.58 2.86e-31 Mean platelet volume; LUSC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg05425664 chr17:57184151 TRIM37 -0.58 -8.86 -0.44 4.84e-17 Intelligence (multi-trait analysis); LUSC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg05234568 chr11:5960015 NA 0.6 9.77 0.47 5.44e-20 DNA methylation (variation); LUSC cis rs10504229 0.679 rs16921677 chr8:58052431 T/C cg21724239 chr8:58056113 NA 0.55 6.55 0.34 2.17e-10 Developmental language disorder (linguistic errors); LUSC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg11742103 chr11:62369870 EML3;MTA2 0.55 9.02 0.44 1.54e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs5753618 0.561 rs2413049 chr22:31686144 A/G cg22777020 chr22:31556080 RNF185 -0.44 -5.66 -0.3 3.24e-8 Colorectal cancer; LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg14004847 chr7:1930337 MAD1L1 0.54 8.02 0.4 1.75e-14 Bipolar disorder and schizophrenia; LUSC trans rs10506458 0.915 rs17738485 chr12:63394932 T/C cg22491629 chr6:157744540 C6orf35 -0.9 -10.83 -0.51 1.29e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg23172400 chr8:95962367 TP53INP1 -0.36 -7.63 -0.39 2.42e-13 Type 2 diabetes; LUSC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg17385448 chr1:15911702 AGMAT 0.37 6.32 0.33 8.16e-10 Systolic blood pressure; LUSC cis rs477895 1.000 rs2286614 chr11:64068310 C/T cg04317338 chr11:64019027 PLCB3 0.57 5.81 0.3 1.48e-8 Mean platelet volume; LUSC cis rs4077515 0.504 rs7628 chr9:139318071 A/G cg14019695 chr9:139328340 INPP5E 0.5 9.54 0.46 3.01e-19 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg01097406 chr16:89675127 NA 0.34 6.75 0.35 6.49e-11 Vitiligo; LUSC cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg24296786 chr1:45957014 TESK2 -0.47 -6.76 -0.35 6.33e-11 High light scatter reticulocyte count; LUSC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg18512352 chr11:47633146 NA -0.48 -9.69 -0.47 9.85e-20 Subjective well-being; LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg27535305 chr1:53392650 SCP2 0.37 6.78 0.35 5.46e-11 Monocyte count; LUSC cis rs714027 0.605 rs2412976 chr22:30567907 C/G cg11564601 chr22:30592435 NA 0.32 5.68 0.3 2.99e-8 Lymphocyte counts; LUSC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg22862634 chr11:62369728 EML3;MTA2 0.59 9.23 0.45 3.24e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1405069 0.809 rs1046279 chr6:36932571 C/T cg26433444 chr6:36932349 PI16 -0.3 -7.3 -0.37 2.09e-12 Chemerin levels; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg16393715 chr7:1948819 MAD1L1 0.34 5.88 0.31 9.8e-9 Bipolar disorder and schizophrenia; LUSC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg16489826 chr6:160211363 TCP1;MRPL18 0.54 6.82 0.35 4.22e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs8072100 0.701 rs8075566 chr17:45771037 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.39 -6.17 -0.32 2.01e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6696846 0.703 rs112653854 chr1:205079251 G/T cg21643547 chr1:205240462 TMCC2 -0.41 -7.6 -0.38 2.93e-13 Red blood cell count; LUSC cis rs10493773 0.566 rs11161659 chr1:86183967 T/C cg17807903 chr1:86174739 ZNHIT6 -0.55 -15.01 -0.63 2.84e-39 Urate levels in overweight individuals; LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg00684032 chr4:1343700 KIAA1530 -0.36 -6.21 -0.32 1.56e-9 Obesity-related traits; LUSC cis rs11779988 0.545 rs404186 chr8:17795496 A/G cg01800426 chr8:17659068 MTUS1 -0.49 -5.92 -0.31 7.82e-9 Breast cancer; LUSC cis rs2806561 0.754 rs10917344 chr1:23342193 C/G cg19743168 chr1:23544995 NA -0.4 -8.26 -0.41 3.43e-15 Height; LUSC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg02073558 chr3:44770973 ZNF501 0.6 9.94 0.48 1.48e-20 Depressive symptoms; LUSC cis rs6728642 0.572 rs7574488 chr2:97599618 T/C cg26665480 chr2:98280029 ACTR1B -0.75 -7.48 -0.38 6.53e-13 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs2764208 0.599 rs9368828 chr6:34661449 A/T cg07306190 chr6:34760872 UHRF1BP1 0.35 6.28 0.32 1.05e-9 Systemic lupus erythematosus; LUSC trans rs3785574 0.962 rs56295011 chr17:61850359 A/G cg09060275 chr22:27053596 MIAT -0.4 -6.03 -0.31 4.45e-9 Height; LUSC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg05234568 chr11:5960015 NA -0.54 -8.24 -0.41 4.05e-15 DNA methylation (variation); LUSC cis rs7927771 0.524 rs7101597 chr11:47797917 A/T cg20307385 chr11:47447363 PSMC3 0.44 6.47 0.33 3.54e-10 Subjective well-being; LUSC cis rs1577917 0.958 rs11758508 chr6:86506878 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.56 7.61 0.38 2.74e-13 Response to antipsychotic treatment; LUSC cis rs6961069 0.585 rs6972923 chr7:80239318 G/C cg04458919 chr7:80252533 CD36 -0.4 -7.32 -0.37 1.91e-12 Platelet count; LUSC cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg08754478 chr10:133766260 PPP2R2D -0.61 -8.04 -0.4 1.57e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9300255 0.509 rs641760 chr12:123518866 T/C cg13010344 chr12:123464640 ARL6IP4 -0.53 -7.09 -0.36 8.11e-12 Neutrophil percentage of white cells; LUSC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg21951975 chr1:209979733 IRF6 0.58 7.59 0.38 3.32e-13 Cleft lip with or without cleft palate; LUSC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg12403142 chr1:92012408 NA -0.42 -6.94 -0.35 2.05e-11 Breast cancer; LUSC cis rs765787 0.530 rs4775832 chr15:45534828 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.7 -0.43 1.5e-16 Uric acid levels; LUSC cis rs8060686 0.516 rs9939821 chr16:68167787 T/A cg09835421 chr16:68378352 PRMT7 -0.49 -6.02 -0.31 4.49e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4409675 0.527 rs1884469 chr1:28239434 G/A cg23691781 chr1:28212827 C1orf38 0.33 8.01 0.4 1.99e-14 Corneal astigmatism; LUSC cis rs754466 0.580 rs2289309 chr10:79571108 C/T cg17075019 chr10:79541650 NA -0.76 -12.19 -0.55 1.55e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7712401 0.623 rs426877 chr5:122314635 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.57 -0.46 2.46e-19 Mean platelet volume; LUSC cis rs2479724 0.598 rs4415146 chr6:41941980 G/T cg17623882 chr6:41773611 USP49 0.46 7.56 0.38 3.97e-13 Menarche (age at onset); LUSC trans rs2715157 1.000 rs2715148 chr7:82450035 A/C cg09060496 chr12:54674110 HNRNPA1;HNRPA1L-2;CBX5 0.37 6.0 0.31 5.12e-9 Major depressive disorder; LUSC cis rs11690935 0.632 rs9789538 chr2:172618474 G/C cg13550731 chr2:172543902 DYNC1I2 0.58 8.95 0.44 2.5e-17 Schizophrenia; LUSC trans rs61931739 0.500 rs6488213 chr12:34393319 C/T cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.35e-33 Morning vs. evening chronotype; LUSC cis rs6582630 0.615 rs3914894 chr12:38480280 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.49 -0.33 3.16e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg26314531 chr2:26401878 FAM59B 0.71 8.93 0.44 2.92e-17 Gut microbiome composition (summer); LUSC cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.71 -9.4 -0.46 8.9e-19 Chronic sinus infection; LUSC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg06238570 chr21:40685208 BRWD1 -0.63 -10.77 -0.51 2.09e-23 Cognitive function; LUSC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg25282410 chr6:160211355 TCP1;MRPL18 1.19 21.84 0.77 2.62e-66 Age-related macular degeneration (geographic atrophy); LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.69 -0.3 2.74e-8 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg07507251 chr3:52567010 NT5DC2 0.36 6.91 0.35 2.39e-11 Bipolar disorder; LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.92 -0.31 7.84e-9 Platelet count; LUSC cis rs9905704 0.671 rs4337355 chr17:56950920 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.33 -0.37 1.75e-12 Testicular germ cell tumor; LUSC cis rs1983170 0.808 rs12080863 chr1:92018721 T/C cg25838465 chr1:92012736 NA 0.42 5.86 0.31 1.09e-8 Eosinophil percentage of white cells; LUSC cis rs2963155 0.590 rs258757 chr5:142620736 A/G cg17617527 chr5:142782415 NR3C1 -0.59 -6.75 -0.35 6.47e-11 Breast cancer; LUSC cis rs4242434 0.819 rs720745 chr8:22471147 G/T cg03733263 chr8:22462867 KIAA1967 0.84 14.44 0.62 4.79e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.51 -0.34 2.82e-10 Colorectal cancer; LUSC cis rs6700896 0.931 rs2154382 chr1:66131681 C/T cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs1994135 0.692 rs7297538 chr12:33693438 T/C cg13010199 chr12:38710504 ALG10B 0.54 7.46 0.38 7.77e-13 Resting heart rate; LUSC cis rs7577696 0.785 rs6723154 chr2:32365161 C/T cg02381751 chr2:32503542 YIPF4 -0.42 -6.04 -0.31 4.1e-9 Inflammatory biomarkers; LUSC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.47 -6.32 -0.33 8.33e-10 Tonsillectomy; LUSC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.78 0.35 5.6e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg10792982 chr14:105748885 BRF1 0.49 8.81 0.43 6.97e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs1055129 0.560 rs3682 chr17:73942150 A/G cg14829360 chr17:73884958 NA -0.35 -5.78 -0.3 1.73e-8 White matter hyperintensity burden; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03341697 chr11:94277138 FUT4 0.42 6.06 0.31 3.72e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg18876405 chr7:65276391 NA 0.75 13.73 0.6 2.5e-34 Calcium levels; LUSC cis rs71636778 0.543 rs75305560 chr1:27242521 T/G cg12203394 chr1:27248618 NUDC 0.53 5.65 0.3 3.47e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg23985595 chr17:80112537 CCDC57 0.34 6.44 0.33 4.21e-10 Life satisfaction; LUSC cis rs853679 0.607 rs17763089 chr6:27835218 G/A cg26958806 chr6:27640298 NA 0.83 6.57 0.34 1.94e-10 Depression; LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg12016809 chr21:47604291 C21orf56 0.46 7.08 0.36 8.7e-12 Testicular germ cell tumor; LUSC cis rs10979 0.597 rs9496687 chr6:143908815 A/G cg25407410 chr6:143891975 LOC285740 -0.61 -7.38 -0.37 1.23e-12 Hypospadias; LUSC cis rs9304742 0.683 rs10402714 chr19:53463680 G/A cg09915433 chr19:53449742 NA -0.57 -9.22 -0.45 3.49e-18 Psoriasis; LUSC cis rs2073300 1.000 rs6114141 chr20:23460620 T/G cg09953122 chr20:23471693 CST8 -0.76 -7.5 -0.38 5.87e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs40363 1.000 rs37767 chr16:3514962 C/T cg00484396 chr16:3507460 NAT15 0.86 11.33 0.53 2.21e-25 Tuberculosis; LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.69 0.47 9.83e-20 Bipolar disorder; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg17091998 chr17:7531155 SHBG;SAT2 0.47 5.95 0.31 6.91e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4423214 0.840 rs1792315 chr11:71165547 C/T cg05163923 chr11:71159392 DHCR7 -0.76 -9.87 -0.48 2.56e-20 Vitamin D levels; LUSC cis rs453301 0.652 rs2043129 chr8:8825504 C/G cg15556689 chr8:8085844 FLJ10661 0.56 8.91 0.44 3.28e-17 Joint mobility (Beighton score); LUSC cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg24642439 chr20:33292090 TP53INP2 0.68 10.0 0.48 8.76e-21 Coronary artery disease; LUSC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg21361702 chr7:150065534 REPIN1 -0.5 -6.43 -0.33 4.41e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg04844267 chr4:1394941 NA 0.32 6.4 0.33 5.29e-10 Obesity-related traits; LUSC cis rs1865760 1.000 rs9358895 chr6:25924655 C/T cg16482183 chr6:26056742 HIST1H1C 0.44 6.52 0.34 2.67e-10 Height; LUSC cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC cis rs2204008 0.575 rs10444564 chr12:38043782 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.74 0.65 3.8e-42 Bladder cancer; LUSC cis rs709400 0.520 rs28583452 chr14:103938664 C/A cg12935359 chr14:103987150 CKB -0.53 -8.29 -0.41 2.76e-15 Body mass index; LUSC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg18240062 chr17:79603768 NPLOC4 0.7 13.06 0.58 8.67e-32 Eye color traits; LUSC cis rs897984 0.520 rs4889536 chr16:30871755 G/T cg02466173 chr16:30829666 NA 0.55 9.23 0.45 3.17e-18 Dementia with Lewy bodies; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26090534 chr13:111314603 CARS2 -0.79 -6.19 -0.32 1.75e-9 Cognitive performance; LUSC cis rs1775715 0.870 rs7912121 chr10:32228995 T/G cg03015672 chr10:32216066 ARHGAP12 0.32 5.81 0.3 1.43e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg08308459 chr2:38893161 GALM -0.57 -5.66 -0.3 3.25e-8 5-HTT brain serotonin transporter levels; LUSC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg12927641 chr6:109611667 NA -0.36 -6.27 -0.32 1.09e-9 Reticulocyte fraction of red cells; LUSC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg21724239 chr8:58056113 NA 0.66 7.4 0.38 1.14e-12 Developmental language disorder (linguistic errors); LUSC cis rs1904096 0.506 rs10024642 chr4:95179295 A/G cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.19 -0.41 5.43e-15 Type 2 diabetes; LUSC cis rs754466 0.580 rs10430530 chr10:79582812 T/C cg17075019 chr10:79541650 NA -0.78 -12.71 -0.57 1.84e-30 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1961456 0.542 rs10095159 chr8:18244684 G/A cg18736775 chr8:18248649 NAT2 -0.55 -6.57 -0.34 1.88e-10 Total cholesterol levels; LUSC cis rs9611519 0.894 rs8136923 chr22:41470522 G/A cg03806693 chr22:41940476 POLR3H -0.55 -7.51 -0.38 5.5e-13 Neuroticism; LUSC cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs4704187 0.687 rs10051040 chr5:74501976 G/C cg03227963 chr5:74354835 NA 0.31 6.76 0.35 6.31e-11 Response to amphetamines; LUSC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg07936489 chr17:37558343 FBXL20 -0.71 -9.8 -0.47 4.38e-20 Glomerular filtration rate (creatinine); LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg27535305 chr1:53392650 SCP2 -0.5 -9.81 -0.47 4.08e-20 Monocyte count; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg15242686 chr22:24348715 GSTTP1 0.43 6.39 0.33 5.53e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg02807482 chr3:125708958 NA -0.52 -6.91 -0.35 2.4e-11 Blood pressure (smoking interaction); LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg11645453 chr3:52864694 ITIH4 -0.34 -7.96 -0.4 2.64e-14 Bipolar disorder; LUSC cis rs11105298 0.891 rs4842654 chr12:89834428 T/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -7.36 -0.37 1.4e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg06454157 chr6:167490870 NA -0.26 -6.19 -0.32 1.75e-9 Crohn's disease; LUSC cis rs4243830 0.850 rs12563717 chr1:6599557 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.89 9.8 0.47 4.13e-20 Body mass index; LUSC cis rs1784581 0.851 rs1784591 chr6:162388893 C/G cg17173639 chr6:162384350 PARK2 -0.84 -16.11 -0.66 1.27e-43 Itch intensity from mosquito bite; LUSC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg05368731 chr17:41323189 NBR1 0.92 15.94 0.66 5.93e-43 Menopause (age at onset); LUSC cis rs35306767 0.633 rs17221491 chr10:1065191 A/G cg25019033 chr10:957182 NA -0.48 -5.92 -0.31 7.79e-9 Eosinophil percentage of granulocytes; LUSC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg01017244 chr2:74357527 NA 0.56 8.91 0.44 3.25e-17 Gestational age at birth (maternal effect); LUSC cis rs400736 0.602 rs4601608 chr1:8168808 A/G cg25007680 chr1:8021821 PARK7 -0.44 -6.57 -0.34 1.96e-10 Response to antidepressants and depression; LUSC trans rs9291683 0.609 rs13149985 chr4:10028390 G/A cg26043149 chr18:55253948 FECH 0.52 7.74 0.39 1.16e-13 Bone mineral density; LUSC cis rs2404602 0.536 rs1587381 chr15:76769620 G/A cg22467129 chr15:76604101 ETFA -0.46 -7.08 -0.36 8.62e-12 Blood metabolite levels; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.7 -0.3 2.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4805272 0.512 rs4805278 chr19:29336664 C/T cg12667521 chr19:29218732 NA 0.51 5.91 0.31 8.28e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs10782582 0.609 rs80059220 chr1:76279112 G/T cg03433033 chr1:76189801 ACADM -0.43 -6.46 -0.33 3.77e-10 Daytime sleep phenotypes; LUSC cis rs6580649 0.941 rs60681522 chr12:48464195 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg10792982 chr14:105748885 BRF1 0.5 9.08 0.45 9.35e-18 Mean platelet volume;Platelet distribution width; LUSC trans rs62238980 0.614 rs117655982 chr22:32461141 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs11229555 0.645 rs61905183 chr11:58228463 T/A cg15696309 chr11:58395628 NA -0.68 -8.26 -0.41 3.34e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs614226 1.000 rs614226 chr12:120974510 C/T cg01236616 chr12:121019343 POP5 -1.28 -20.57 -0.75 2.54e-61 Type 1 diabetes nephropathy; LUSC cis rs1559088 0.625 rs10411739 chr19:33616327 T/C cg27124370 chr19:33622961 WDR88 0.56 7.83 0.39 6.54e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs34779708 0.931 rs7084196 chr10:35367161 T/C cg04310649 chr10:35416472 CREM -0.41 -6.48 -0.33 3.22e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11583043 0.575 rs7528842 chr1:101583663 G/T cg11406453 chr1:101602562 NA 0.41 7.06 0.36 9.53e-12 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4971059 0.507 rs11264321 chr1:155085898 C/A cg23973274 chr1:155060172 NA -0.29 -5.72 -0.3 2.38e-8 Breast cancer; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg24503407 chr1:205819492 PM20D1 1.01 22.85 0.78 3.1e-70 Menarche (age at onset); LUSC cis rs9486715 0.867 rs2499774 chr6:97006581 C/G cg06623918 chr6:96969491 KIAA0776 -0.93 -17.6 -0.69 1.57e-49 Headache; LUSC cis rs6920965 0.527 rs7763515 chr6:126174714 C/G cg05901451 chr6:126070800 HEY2 -0.39 -5.65 -0.3 3.48e-8 High light scatter reticulocyte count; LUSC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg16339924 chr4:17578868 LAP3 0.56 8.67 0.43 1.94e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs62458065 0.640 rs10271491 chr7:32530665 C/A cg20159608 chr7:32802032 NA -0.76 -9.58 -0.46 2.32e-19 Metabolite levels (HVA/MHPG ratio); LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg24632597 chr12:121648093 P2RX4 0.39 6.12 0.32 2.6e-9 Educational attainment (years of education); LUSC trans rs17807624 0.780 rs11250152 chr8:11454200 A/C cg15556689 chr8:8085844 FLJ10661 -0.46 -6.69 -0.34 9.46e-11 Systemic lupus erythematosus; LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg07092213 chr7:1199455 ZFAND2A -0.43 -6.58 -0.34 1.77e-10 Longevity;Endometriosis; LUSC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.74 0.6 2.27e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg16405210 chr4:1374714 KIAA1530 -0.59 -9.04 -0.44 1.26e-17 Obesity-related traits; LUSC cis rs950027 0.620 rs1145089 chr15:45652054 G/C cg14582100 chr15:45693742 SPATA5L1 0.45 8.57 0.42 3.77e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08704250 chr15:31115839 NA -0.48 -6.76 -0.35 6.35e-11 Huntington's disease progression; LUSC trans rs2797160 1.000 rs1739354 chr6:126017808 G/C cg05039488 chr6:79577232 IRAK1BP1 0.46 6.87 0.35 3.16e-11 Endometrial cancer; LUSC cis rs7605827 0.897 rs6431697 chr2:15540034 G/C cg19274914 chr2:15703543 NA 0.47 9.24 0.45 3.06e-18 Educational attainment (years of education); LUSC cis rs2952156 1.000 rs1810132 chr17:37866005 C/T cg20243544 chr17:37824526 PNMT 0.48 6.75 0.35 6.7e-11 Asthma; LUSC trans rs11039798 0.588 rs59777067 chr11:49015350 C/T cg03929089 chr4:120376271 NA 0.71 7.71 0.39 1.5e-13 Axial length; LUSC cis rs988712 0.672 rs36029218 chr11:27648371 A/T cg10635145 chr11:27742435 BDNF -0.46 -5.97 -0.31 6.2e-9 Obesity; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg12564285 chr5:131593104 PDLIM4 -0.44 -7.85 -0.39 5.52e-14 Breast cancer; LUSC cis rs7465272 1.000 rs35476574 chr8:143683784 C/A cg01509843 chr8:143695822 ARC 0.39 5.91 0.31 8.25e-9 Bipolar disorder and schizophrenia; LUSC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg04267008 chr7:1944627 MAD1L1 0.54 8.36 0.42 1.71e-15 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -12.05 -0.55 5.39e-28 Systemic lupus erythematosus; LUSC cis rs754466 0.606 rs3740250 chr10:79580101 C/T cg17075019 chr10:79541650 NA -0.76 -11.98 -0.55 9.44e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs473651 0.935 rs558924 chr2:239339511 A/G cg18131467 chr2:239335373 ASB1 0.87 13.86 0.6 8.26e-35 Multiple system atrophy; LUSC cis rs6574644 0.920 rs1957542 chr14:81777303 G/C cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg16479474 chr6:28041457 NA 0.34 5.89 0.31 9.45e-9 Parkinson's disease; LUSC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg14784868 chr12:69753453 YEATS4 0.91 16.19 0.66 6.39e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs6696846 0.905 rs12117194 chr1:205040943 C/G cg21545522 chr1:205238299 TMCC2 -0.4 -7.63 -0.39 2.4e-13 Red blood cell count; LUSC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg00129232 chr17:37814104 STARD3 -0.43 -6.25 -0.32 1.26e-9 Asthma; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg01802117 chr1:53393560 SCP2 0.38 6.14 0.32 2.4e-9 Monocyte count; LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.81 -0.43 6.75e-17 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23779087 chr6:151711584 ZBTB2 0.46 6.52 0.34 2.61e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8068544 0.748 rs75881902 chr17:40156612 C/A cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -1.24 -11.41 -0.53 1.14e-25 Reticulocyte fraction of red cells;Reticulocyte count; LUSC cis rs12599106 0.754 rs11640596 chr16:34347277 T/C cg01585723 chr16:33734837 NA 0.37 5.88 0.31 1.01e-8 Menopause (age at onset); LUSC cis rs2361710 0.669 rs12940486 chr17:78118569 T/C cg20811857 chr17:78079795 GAA -0.32 -6.04 -0.31 4.06e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs11190604 1.000 rs2295774 chr10:102265847 A/C cg07080220 chr10:102295463 HIF1AN 0.68 8.76 0.43 9.71e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg11764359 chr7:65958608 NA 0.7 10.74 0.51 2.56e-23 Aortic root size; LUSC cis rs6736093 0.863 rs35757708 chr2:112769902 T/C cg12686935 chr2:112915763 FBLN7 -0.37 -6.03 -0.31 4.43e-9 Coronary artery disease; LUSC cis rs16854884 0.657 rs35877644 chr3:143701755 A/G cg06585982 chr3:143692056 C3orf58 0.49 7.47 0.38 7.17e-13 Economic and political preferences (feminism/equality); LUSC cis rs3847687 0.901 rs12370258 chr12:131527301 G/T cg13586425 chr12:131519906 GPR133 -0.26 -5.96 -0.31 6.27e-9 Longevity; LUSC cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg16145915 chr7:1198662 ZFAND2A -0.43 -6.29 -0.33 9.99e-10 Bronchopulmonary dysplasia; LUSC trans rs9951602 0.512 rs7232551 chr18:76650702 G/A cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC cis rs2652834 0.950 rs4774474 chr15:63405580 C/G cg05507819 chr15:63340323 TPM1 0.56 6.98 0.36 1.57e-11 HDL cholesterol; LUSC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.58 -0.38 3.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg20476274 chr7:133979776 SLC35B4 0.81 14.5 0.62 2.68e-37 Mean platelet volume; LUSC cis rs35110281 0.501 rs162378 chr21:44925905 A/G cg01579765 chr21:45077557 HSF2BP 0.45 8.36 0.42 1.73e-15 Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12637942 chr11:65190225 NEAT1 0.47 6.24 0.32 1.33e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg01579765 chr21:45077557 HSF2BP -0.5 -10.36 -0.49 5.28e-22 Mean corpuscular volume; LUSC cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.61 -7.92 -0.4 3.5e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg08859206 chr1:53392774 SCP2 -0.4 -6.57 -0.34 1.94e-10 Monocyte count; LUSC cis rs6598955 0.543 rs3795687 chr1:26560745 G/A cg12744634 chr1:26560303 CCDC21 0.4 5.92 0.31 8.03e-9 Obesity-related traits; LUSC cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.41 -5.88 -0.31 1e-8 Schizophrenia; LUSC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg01368799 chr11:117014884 PAFAH1B2 0.48 6.24 0.32 1.34e-9 Blood protein levels; LUSC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg26513180 chr16:89883248 FANCA 0.66 10.66 0.5 4.79e-23 Vitiligo; LUSC cis rs13089785 0.965 rs62263719 chr3:123672787 T/C cg02558132 chr3:123411198 MYLK 0.35 5.87 0.31 1.05e-8 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg27266027 chr21:40555129 PSMG1 -0.4 -5.84 -0.3 1.24e-8 Cognitive function; LUSC cis rs10254118 0.757 rs13241123 chr7:133135507 A/T cg10665199 chr7:133106180 EXOC4 0.61 8.18 0.41 5.83e-15 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg01097406 chr16:89675127 NA -0.36 -7.17 -0.37 4.72e-12 Vitiligo; LUSC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.28 -0.37 2.39e-12 Extrinsic epigenetic age acceleration; LUSC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg00031303 chr3:195681400 NA 0.67 9.55 0.46 2.79e-19 Pancreatic cancer; LUSC trans rs11764590 0.715 rs9969125 chr7:2088460 C/T cg25206134 chr2:45395956 NA 0.56 6.14 0.32 2.38e-9 Neuroticism; LUSC cis rs1448094 0.802 rs11117146 chr12:86382870 C/T cg02569458 chr12:86230093 RASSF9 -0.37 -5.93 -0.31 7.51e-9 Major depressive disorder; LUSC cis rs2730245 0.527 rs842700 chr7:158697565 G/A cg11984989 chr7:158649758 WDR60 1.12 13.46 0.59 2.68e-33 Height; LUSC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg11062466 chr8:58055876 NA 0.51 6.53 0.34 2.49e-10 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg22907277 chr7:1156413 C7orf50 0.47 7.61 0.38 2.88e-13 Longevity;Endometriosis; LUSC cis rs6469656 0.892 rs7836549 chr8:117697574 G/C cg24004040 chr8:117650383 NA -0.43 -6.31 -0.33 9.04e-10 Colorectal cancer; LUSC cis rs4363385 0.782 rs2152993 chr1:152991695 C/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.45 -0.38 8.32e-13 Inflammatory skin disease; LUSC trans rs637571 0.565 rs633800 chr11:65638719 G/A cg17712092 chr4:129076599 LARP1B -0.86 -12.99 -0.58 1.64e-31 Eosinophil percentage of white cells; LUSC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 7.39 0.37 1.17e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4819143 0.517 rs451920 chr21:47374699 A/C cg14185626 chr21:47401492 COL6A1 -0.46 -5.68 -0.3 2.89e-8 Insulin resistance/response; LUSC cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg05283184 chr6:79620031 NA -0.57 -12.2 -0.56 1.41e-28 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.775 rs4777477 chr15:72269612 G/A cg16672083 chr15:72433130 SENP8 -0.51 -7.41 -0.38 1.02e-12 Red blood cell count; LUSC cis rs6598955 0.671 rs12129482 chr1:26623641 C/T cg00852783 chr1:26633632 UBXN11 -0.5 -5.86 -0.31 1.13e-8 Obesity-related traits; LUSC cis rs240764 0.697 rs846799 chr6:101270345 A/G cg09795085 chr6:101329169 ASCC3 0.46 6.57 0.34 1.91e-10 Neuroticism; LUSC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg18230493 chr5:56204884 C5orf35 -0.65 -9.8 -0.47 4.27e-20 Coronary artery disease; LUSC cis rs2760061 0.626 rs591582 chr1:228117360 C/A cg01973587 chr1:228161476 NA 0.46 8.28 0.41 2.98e-15 Diastolic blood pressure; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.47 7.81 0.39 7.67e-14 Lymphocyte counts; LUSC cis rs668210 0.793 rs645571 chr11:65752852 A/T cg02202077 chr11:65769826 EIF1AD;BANF1 -0.59 -7.48 -0.38 6.61e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs3936840 0.514 rs8007356 chr14:102975266 G/A cg18135206 chr14:102964638 TECPR2 0.52 6.89 0.35 2.75e-11 Plateletcrit; LUSC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs7937682 0.921 rs4616071 chr11:111440865 C/G cg11344533 chr11:111475393 SIK2 0.47 6.15 0.32 2.21e-9 Primary sclerosing cholangitis; LUSC cis rs11630290 0.589 rs12324851 chr15:64163495 G/A cg12036633 chr15:63758958 NA 0.49 6.23 0.32 1.37e-9 Iris characteristics; LUSC cis rs9733 0.650 rs12406712 chr1:150545084 C/A cg09365446 chr1:150670422 GOLPH3L -0.44 -6.37 -0.33 6.29e-10 Tonsillectomy; LUSC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9329221 0.662 rs34155841 chr8:10247529 T/G cg21775007 chr8:11205619 TDH 0.46 6.05 0.31 3.92e-9 Neuroticism; LUSC trans rs9329221 0.905 rs28712068 chr8:10251145 G/C cg06636001 chr8:8085503 FLJ10661 -0.54 -7.85 -0.39 5.63e-14 Neuroticism; LUSC cis rs2070433 0.556 rs8129460 chr21:47822544 C/T cg12379764 chr21:47803548 PCNT 0.77 10.1 0.48 4.32e-21 Lymphocyte counts; LUSC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg12564285 chr5:131593104 PDLIM4 0.32 5.87 0.31 1.04e-8 Breast cancer;Mosquito bite size; LUSC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg11301795 chr4:187892539 NA 0.46 6.78 0.35 5.63e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs8113142 0.651 rs4309511 chr19:29094875 G/A cg04546413 chr19:29218101 NA 0.43 5.9 0.31 8.86e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs868036 0.681 rs9920643 chr15:68104314 C/T cg24579218 chr15:68104479 NA -0.39 -6.81 -0.35 4.68e-11 Restless legs syndrome; LUSC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg26597838 chr10:835615 NA 1.07 13.74 0.6 2.38e-34 Eosinophil percentage of granulocytes; LUSC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.15 0.49 2.78e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs885518 0.636 rs10811612 chr9:21774167 C/G cg03374820 chr3:103513634 NA -0.62 -6.0 -0.31 5.27e-9 Lung adenocarcinoma; LUSC cis rs9287719 0.967 rs6432114 chr2:10744930 C/T cg00105475 chr2:10696890 NA 0.38 6.29 0.33 1e-9 Prostate cancer; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg16393715 chr7:1948819 MAD1L1 0.37 6.53 0.34 2.43e-10 Bipolar disorder and schizophrenia; LUSC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs208520 1.000 rs72884017 chr6:66992513 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 11.92 0.55 1.59e-27 Exhaled nitric oxide output; LUSC cis rs8058578 1.000 rs7198250 chr16:30746822 C/A cg02466173 chr16:30829666 NA -0.6 -11.22 -0.52 5.43e-25 Multiple myeloma; LUSC cis rs25645 0.760 rs11870683 chr17:38129841 T/A cg17467752 chr17:38218738 THRA -0.48 -6.68 -0.34 9.96e-11 Myeloid white cell count; LUSC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg04998671 chr14:104000505 TRMT61A -0.41 -5.92 -0.31 7.94e-9 Reticulocyte count; LUSC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs11048434 0.736 rs11048195 chr12:9105923 A/G cg04155231 chr12:9217510 LOC144571 0.3 5.69 0.3 2.75e-8 Sjögren's syndrome; LUSC cis rs9549260 0.755 rs1413482 chr13:41218451 C/T cg21288729 chr13:41239152 FOXO1 0.64 10.0 0.48 9.34e-21 Red blood cell count; LUSC cis rs3768617 0.782 rs10752893 chr1:183046261 C/T ch.1.3577855R chr1:183094577 LAMC1 0.6 8.64 0.43 2.29e-16 Fuchs's corneal dystrophy; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg11172286 chr11:47600544 KBTBD4;NDUFS3 0.39 5.98 0.31 5.81e-9 Eotaxin levels; LUSC cis rs9527 0.590 rs7920868 chr10:104795409 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.35 -0.33 6.93e-10 Arsenic metabolism; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg10729496 chr3:10149963 C3orf24 0.57 7.42 0.38 9.8e-13 Alzheimer's disease; LUSC trans rs4332037 0.539 rs11763750 chr7:2080114 G/A cg11693508 chr17:37793320 STARD3 0.52 6.2 0.32 1.63e-9 Bipolar disorder; LUSC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.59 0.5 8.51e-23 Schizophrenia; LUSC cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg05768032 chr16:30646687 NA 0.38 5.68 0.3 2.96e-8 Multiple myeloma; LUSC cis rs1355223 0.583 rs2915178 chr11:34878051 C/T cg11058730 chr11:34937778 PDHX;APIP 0.68 11.05 0.52 2.08e-24 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg06627628 chr2:24431161 ITSN2 -0.61 -7.4 -0.38 1.09e-12 Lymphocyte counts; LUSC cis rs4988958 0.565 rs3771154 chr2:103039360 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.39e-12 Asthma (childhood onset); LUSC cis rs13401104 0.796 rs72620805 chr2:237113711 G/C cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.35e-8 Educational attainment; LUSC cis rs6977660 0.943 rs6959678 chr7:19821759 C/A cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs7605827 0.866 rs7598936 chr2:15597289 A/G cg19274914 chr2:15703543 NA 0.46 8.8 0.43 7.47e-17 Educational attainment (years of education); LUSC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg25456477 chr12:86230367 RASSF9 0.43 7.69 0.39 1.69e-13 Major depressive disorder; LUSC cis rs12701220 0.817 rs1058729 chr7:1087283 C/T cg23978390 chr7:1156363 C7orf50 0.48 5.98 0.31 5.68e-9 Bronchopulmonary dysplasia; LUSC cis rs847577 1.000 rs847577 chr7:97694858 T/A cg24562669 chr7:97807699 LMTK2 -0.44 -7.96 -0.4 2.65e-14 Breast cancer; LUSC cis rs9457247 0.668 rs2236313 chr6:167360389 C/T cg07741184 chr6:167504864 NA 0.36 6.52 0.34 2.53e-10 Crohn's disease; LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg00814883 chr7:100076585 TSC22D4 -0.75 -9.49 -0.46 4.67e-19 Platelet count; LUSC cis rs34779708 0.931 rs12268745 chr10:35305989 C/G cg03585969 chr10:35415529 CREM 0.61 8.81 0.43 7.16e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7589342 0.745 rs11124066 chr2:106516925 T/A cg14210321 chr2:106509881 NCK2 -0.62 -9.47 -0.46 5.26e-19 Addiction; LUSC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg24399712 chr22:39784796 NA -0.64 -12.0 -0.55 8.04e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg21782813 chr7:2030301 MAD1L1 0.48 8.04 0.4 1.61e-14 Bipolar disorder and schizophrenia; LUSC cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.39 0.42 1.41e-15 Menarche (age at onset); LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.78 0.39 8.84e-14 Prudent dietary pattern; LUSC cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg00290607 chr11:67383545 NA 0.36 6.33 0.33 8e-10 Mean corpuscular volume; LUSC cis rs5758511 0.633 rs5758689 chr22:42664972 T/G cg00645731 chr22:42541494 CYP2D7P1 0.58 10.2 0.49 1.97e-21 Birth weight; LUSC cis rs2346177 0.519 rs13003074 chr2:46671420 A/T cg26688816 chr2:46740690 ATP6V1E2 0.56 8.86 0.44 4.85e-17 HDL cholesterol; LUSC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg11062466 chr8:58055876 NA 0.51 6.46 0.33 3.65e-10 Developmental language disorder (linguistic errors); LUSC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg08564027 chr20:61660810 NA 0.9 16.84 0.68 1.64e-46 Prostate cancer (SNP x SNP interaction); LUSC cis rs1790761 0.692 rs674783 chr11:67339076 C/T cg23188684 chr11:67383651 NA 0.35 6.19 0.32 1.76e-9 Mean corpuscular volume; LUSC cis rs4494114 1.000 rs6675245 chr1:39356820 T/A cg25970120 chr1:39325951 RRAGC -0.4 -6.22 -0.32 1.46e-9 Blood protein levels; LUSC cis rs2274273 0.868 rs6573007 chr14:55625938 T/G cg04306507 chr14:55594613 LGALS3 0.59 13.65 0.6 5.06e-34 Protein biomarker; LUSC cis rs8114671 0.628 rs6060130 chr20:33549319 C/T cg24642439 chr20:33292090 TP53INP2 0.42 6.02 0.31 4.72e-9 Height; LUSC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg15445000 chr17:37608096 MED1 0.4 6.83 0.35 4.04e-11 Glomerular filtration rate (creatinine); LUSC cis rs10392 0.571 rs4812335 chr20:37537612 C/T cg27552599 chr20:37590471 DHX35 0.41 6.44 0.33 4.08e-10 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg14262678 chr6:151773367 RMND1;C6orf211 -0.46 -7.51 -0.38 5.41e-13 Menarche (age at onset); LUSC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.83 0.39 6.31e-14 Major depressive disorder; LUSC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg25456477 chr12:86230367 RASSF9 0.43 7.75 0.39 1.15e-13 Major depressive disorder; LUSC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg06740227 chr12:86229804 RASSF9 0.39 6.25 0.32 1.23e-9 Major depressive disorder; LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg09877947 chr5:131593287 PDLIM4 0.48 8.24 0.41 4.1e-15 Blood metabolite levels; LUSC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg23758822 chr17:41437982 NA 1.02 20.24 0.74 5.16e-60 Menopause (age at onset); LUSC cis rs6964587 1.000 rs10234290 chr7:91716951 T/C cg17063962 chr7:91808500 NA 0.59 9.25 0.45 2.65e-18 Breast cancer; LUSC cis rs10464366 0.746 rs4723821 chr7:39141532 A/G cg21665744 chr7:39171113 POU6F2 0.44 6.69 0.34 9.23e-11 IgG glycosylation; LUSC cis rs858239 0.570 rs10242166 chr7:23162799 A/G cg23682824 chr7:23144976 KLHL7 0.38 5.67 0.3 3.1e-8 Cerebrospinal fluid biomarker levels; LUSC trans rs877282 0.853 rs11593836 chr10:756715 G/A cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs8016982 0.662 rs9806020 chr14:81668555 A/C cg01989461 chr14:81687754 GTF2A1 0.49 6.72 0.35 7.73e-11 Schizophrenia; LUSC cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg13770153 chr20:60521292 NA -0.44 -6.11 -0.32 2.83e-9 Body mass index; LUSC cis rs3106136 0.967 rs66581998 chr4:95196901 T/C cg11021082 chr4:95130006 SMARCAD1 -0.36 -6.4 -0.33 5.19e-10 Capecitabine sensitivity; LUSC cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14442939 chr10:27389572 ANKRD26 0.84 9.84 0.47 3.2e-20 Breast cancer; LUSC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg13395646 chr4:1353034 KIAA1530 -0.61 -9.9 -0.48 2.03e-20 Obesity-related traits; LUSC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg23277830 chr1:3704460 LRRC47 0.36 6.84 0.35 3.9e-11 Red cell distribution width; LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg05896524 chr21:47604654 C21orf56 -0.53 -8.12 -0.41 8.81e-15 Testicular germ cell tumor; LUSC cis rs2180341 0.618 rs11154398 chr6:127654281 C/A cg24812749 chr6:127587940 RNF146 0.64 9.56 0.46 2.76e-19 Breast cancer; LUSC cis rs7107174 0.892 rs2512540 chr11:77979299 A/G cg02023728 chr11:77925099 USP35 0.48 6.82 0.35 4.26e-11 Testicular germ cell tumor; LUSC cis rs16976116 0.901 rs28714578 chr15:55491121 G/A cg11288833 chr15:55489084 RSL24D1 0.49 5.84 0.3 1.24e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs734999 0.545 rs10797436 chr1:2538349 G/A cg18854424 chr1:2615690 NA 0.51 10.31 0.49 7.93e-22 Ulcerative colitis; LUSC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg18681998 chr4:17616180 MED28 0.92 18.35 0.71 1.66e-52 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7954584 0.813 rs11043288 chr12:122451187 C/T cg01765077 chr12:122356316 WDR66 -0.44 -6.2 -0.32 1.68e-9 Mean corpuscular volume; LUSC cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.54 -0.34 2.28e-10 Arsenic metabolism; LUSC cis rs72781680 0.821 rs113014365 chr2:24159903 C/T cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg14004847 chr7:1930337 MAD1L1 -0.49 -7.51 -0.38 5.53e-13 Bipolar disorder and schizophrenia; LUSC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg13770153 chr20:60521292 NA -0.62 -8.34 -0.42 1.95e-15 Body mass index; LUSC trans rs2926702 0.810 rs2979638 chr8:71067368 G/A cg16517358 chr11:46164796 NA -0.37 -5.98 -0.31 5.84e-9 Non-small cell lung cancer; LUSC cis rs1832871 0.965 rs705953 chr6:158775332 A/G cg07165851 chr6:158734300 TULP4 -0.34 -5.87 -0.31 1.07e-8 Height; LUSC cis rs8072100 0.701 rs8075566 chr17:45771037 G/A cg19784903 chr17:45786737 TBKBP1 -0.42 -6.11 -0.32 2.76e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg11812906 chr14:75593930 NEK9 0.66 11.33 0.53 2.14e-25 Height; LUSC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg12310025 chr6:25882481 NA 0.47 8.68 0.43 1.77e-16 Blood metabolite levels; LUSC trans rs6480314 0.542 rs12570281 chr10:70026994 T/G cg04882175 chr6:131122610 NA -0.55 -6.39 -0.33 5.64e-10 Optic nerve measurement (disc area); LUSC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg25427524 chr10:38739819 LOC399744 -0.72 -13.51 -0.59 1.8e-33 Extrinsic epigenetic age acceleration; LUSC cis rs1559088 0.948 rs10406916 chr19:33590093 G/A cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.38e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10875746 0.855 rs12310999 chr12:48447658 A/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC trans rs2243480 0.711 rs2420172 chr7:65635341 T/C cg10756647 chr7:56101905 PSPH -0.84 -8.39 -0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg22532475 chr10:104410764 TRIM8 0.3 6.16 0.32 2.03e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9457247 0.765 rs9457256 chr6:167436461 T/C cg06454157 chr6:167490870 NA -0.25 -5.99 -0.31 5.58e-9 Crohn's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25728723 chr11:3818859 PGAP2;NUP98 0.77 6.62 0.34 1.44e-10 Cognitive performance; LUSC trans rs272594 1.000 rs272594 chr8:81470120 A/C cg01004056 chr1:230560318 NA -0.43 -5.97 -0.31 6.16e-9 Neutrophil count; LUSC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg26116260 chr4:7069785 GRPEL1 -1.08 -12.72 -0.57 1.75e-30 Monocyte percentage of white cells; LUSC cis rs2486288 0.656 rs11631021 chr15:45556829 A/G cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.78 -0.51 1.85e-23 Glomerular filtration rate; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg06873352 chr17:61820015 STRADA 0.7 12.71 0.57 1.91e-30 Prudent dietary pattern; LUSC cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg06784218 chr1:46089804 CCDC17 -0.6 -11.93 -0.55 1.37e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg24675658 chr1:53192096 ZYG11B -0.64 -10.09 -0.48 4.52e-21 Monocyte count; LUSC cis rs9814567 0.929 rs1534027 chr3:134284662 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -13.85 -0.6 9.01e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4925325 0.915 rs2427246 chr20:60517047 T/C cg16423285 chr20:60520624 NA -0.92 -12.73 -0.57 1.5e-30 Obesity-related traits; LUSC cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg18681998 chr4:17616180 MED28 0.81 13.89 0.61 5.89e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6547741 0.844 rs7586655 chr2:27915659 A/G cg12559939 chr2:27858050 GPN1 -0.4 -6.25 -0.32 1.23e-9 Oral cavity cancer; LUSC cis rs4604732 0.574 rs111928142 chr1:247625229 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.38 0.33 5.74e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs12586317 0.620 rs8021414 chr14:35581480 T/A cg16230307 chr14:35515116 FAM177A1 0.77 10.07 0.48 5.28e-21 Psoriasis; LUSC cis rs35000415 0.872 rs2070197 chr7:128589000 T/C cg19972273 chr7:128594194 NA 0.67 6.79 0.35 5.17e-11 Systemic lupus erythematosus; LUSC cis rs6484504 0.576 rs2616792 chr11:31324298 T/G cg26647111 chr11:31128758 NA 0.4 5.67 0.3 3.02e-8 Red blood cell count; LUSC cis rs2658782 0.654 rs2248524 chr11:93255715 G/A cg15737290 chr11:93063684 CCDC67 0.57 7.4 0.38 1.14e-12 Pulmonary function decline; LUSC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg17764715 chr19:33622953 WDR88 0.57 8.35 0.42 1.84e-15 Bone properties (heel); LUSC cis rs34779708 0.966 rs998658 chr10:35408654 A/G cg03585969 chr10:35415529 CREM 0.58 8.68 0.43 1.82e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6982240 0.514 rs72681579 chr8:142263074 G/A cg27411547 chr8:142287226 NA -0.47 -7.95 -0.4 2.98e-14 Tonsillectomy; LUSC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg25554036 chr4:6271136 WFS1 0.59 11.91 0.55 1.73e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs3741151 0.773 rs73542967 chr11:73123512 C/T cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs12048904 0.541 rs1571046 chr1:101299216 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.7 9.81 0.47 4.06e-20 Multiple sclerosis; LUSC cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg06550200 chr5:1325588 CLPTM1L -0.66 -11.27 -0.52 3.4e-25 Lung cancer; LUSC cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg09184832 chr6:79620586 NA -0.44 -7.09 -0.36 7.85e-12 Intelligence (multi-trait analysis); LUSC cis rs11039100 0.920 rs11039075 chr11:5820917 C/A cg13902645 chr11:5959945 NA -0.53 -5.94 -0.31 7.09e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7572644 0.766 rs13399709 chr2:28167450 C/T cg27432699 chr2:27873401 GPN1 -0.52 -6.49 -0.33 3.1e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.56 0.34 2e-10 Neutrophil percentage of white cells; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg14004847 chr7:1930337 MAD1L1 -0.55 -8.5 -0.42 6.5e-16 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.806 rs11525001 chr12:38234397 A/G cg26384229 chr12:38710491 ALG10B 0.88 15.13 0.64 9.83e-40 Bladder cancer; LUSC cis rs1322512 0.837 rs2800627 chr6:153006507 C/A cg03415253 chr6:152958462 SYNE1 0.38 5.65 0.3 3.38e-8 Tonometry; LUSC cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg24596788 chr1:163392923 NA -0.44 -7.27 -0.37 2.55e-12 Motion sickness; LUSC trans rs9291683 0.530 rs13115193 chr4:9982191 C/T cg26043149 chr18:55253948 FECH 0.47 7.16 0.36 5.05e-12 Bone mineral density; LUSC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg04362960 chr10:104952993 NT5C2 0.52 6.54 0.34 2.35e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg26647111 chr11:31128758 NA -0.42 -6.03 -0.31 4.44e-9 Red blood cell count; LUSC cis rs9300255 0.544 rs1716157 chr12:123670473 T/C cg00376283 chr12:123451042 ABCB9 0.67 8.36 0.42 1.68e-15 Neutrophil percentage of white cells; LUSC cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg03146154 chr1:46216737 IPP -0.5 -7.23 -0.37 3.29e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11098499 0.588 rs2389874 chr4:120554991 A/G cg09307838 chr4:120376055 NA -0.59 -8.99 -0.44 1.88e-17 Corneal astigmatism; LUSC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.39 0.53 1.32e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg08888203 chr3:10149979 C3orf24 0.45 6.79 0.35 5.25e-11 Alzheimer's disease; LUSC cis rs7560272 0.564 rs4852939 chr2:73856769 C/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.99 -0.36 1.5e-11 Schizophrenia; LUSC cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg10057126 chr4:77819792 ANKRD56 0.54 7.89 0.4 4.25e-14 Emphysema distribution in smoking; LUSC cis rs77106637 0.932 rs2886599 chr11:72721271 C/A cg03713592 chr11:72463424 ARAP1 0.84 9.78 0.47 4.81e-20 Type 2 diabetes; LUSC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg16520312 chr17:43971471 MAPT;LOC100128977 0.38 6.51 0.34 2.78e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7799006 0.757 rs2398668 chr7:2298227 A/G cg08027265 chr7:2291960 NA 0.6 11.31 0.53 2.45e-25 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2952156 1.000 rs4252627 chr17:37868715 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.06 -0.36 9.53e-12 Asthma; LUSC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg08888203 chr3:10149979 C3orf24 0.46 6.72 0.35 7.83e-11 Alzheimer's disease; LUSC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.47 0.42 7.7e-16 Hemoglobin concentration; LUSC cis rs2273669 0.667 rs2356575 chr6:109367255 T/C cg05315195 chr6:109294784 ARMC2 -0.52 -5.72 -0.3 2.42e-8 Prostate cancer; LUSC cis rs9393777 0.588 rs6941920 chr6:26492149 C/T cg12826209 chr6:26865740 GUSBL1 0.68 7.85 0.39 5.75e-14 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.606 rs6422352 chr8:8794193 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.71 -0.43 1.46e-16 Mood instability; LUSC cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg05347473 chr6:146136440 FBXO30 0.53 8.96 0.44 2.33e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg00750074 chr16:89608354 SPG7 -0.57 -10.24 -0.49 1.4e-21 Multiple myeloma (IgH translocation); LUSC cis rs72781680 0.559 rs72796103 chr2:23900382 G/A cg20701182 chr2:24300061 SF3B14 0.75 7.32 0.37 1.87e-12 Lymphocyte counts; LUSC cis rs73198271 0.562 rs17698256 chr8:8659613 C/T cg01851573 chr8:8652454 MFHAS1 0.65 9.19 0.45 4.29e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12549902 0.932 rs6981607 chr8:41508168 A/C cg21772509 chr8:41503840 NKX6-3 0.69 11.53 0.53 4.11e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg10295955 chr4:187884368 NA -1.07 -26.09 -0.82 1.35e-82 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.739 rs951570 chr4:120150467 T/C cg25214090 chr10:38739885 LOC399744 -0.41 -6.26 -0.32 1.2e-9 Corneal astigmatism; LUSC cis rs4077515 0.874 rs10781505 chr9:139271355 C/T cg14019695 chr9:139328340 INPP5E -0.39 -7.36 -0.37 1.49e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1729951 0.575 rs1654923 chr3:136692620 A/T cg21827317 chr3:136751795 NA 0.39 6.96 0.36 1.84e-11 Neuroticism; LUSC cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg26587870 chr6:27730563 NA -0.61 -5.79 -0.3 1.62e-8 Breast cancer; LUSC cis rs2200578 0.626 rs72959128 chr2:99769602 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 0.62 7.31 0.37 2.01e-12 IgG glycosylation; LUSC trans rs7615952 0.800 rs2062773 chr3:125639648 T/C cg07211511 chr3:129823064 LOC729375 -1.23 -21.07 -0.76 2.67e-63 Blood pressure (smoking interaction); LUSC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg15445000 chr17:37608096 MED1 0.39 6.63 0.34 1.38e-10 Glomerular filtration rate (creatinine); LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg18876405 chr7:65276391 NA -0.53 -8.67 -0.43 1.86e-16 Calcium levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05871997 chr6:56819623 BEND6;DST 0.69 6.26 0.32 1.19e-9 Cognitive performance; LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg20295408 chr7:1910781 MAD1L1 -0.44 -6.24 -0.32 1.32e-9 Bipolar disorder and schizophrenia; LUSC cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg16586182 chr3:47516702 SCAP 0.57 8.92 0.44 3.05e-17 Colorectal cancer; LUSC cis rs17270561 0.636 rs9393656 chr6:25722059 A/C cg16482183 chr6:26056742 HIST1H1C 0.63 8.86 0.44 4.85e-17 Iron status biomarkers; LUSC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg02038168 chr22:39784481 NA -0.49 -8.04 -0.4 1.55e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs62400317 0.859 rs10948213 chr6:45158515 T/C cg20913747 chr6:44695427 NA -0.48 -7.7 -0.39 1.56e-13 Total body bone mineral density; LUSC trans rs9329221 0.686 rs35840352 chr8:10239807 A/G cg06636001 chr8:8085503 FLJ10661 0.56 7.8 0.39 7.8e-14 Neuroticism; LUSC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs6547741 0.967 rs4665995 chr2:27813827 T/G cg12559939 chr2:27858050 GPN1 0.41 6.45 0.33 3.94e-10 Oral cavity cancer; LUSC cis rs1113500 0.548 rs11185269 chr1:108647636 T/C cg11967332 chr1:108735228 SLC25A24 0.43 5.88 0.31 1.02e-8 Growth-regulated protein alpha levels; LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg21280719 chr6:42927975 GNMT 0.3 7.66 0.39 2.04e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs741677 0.702 rs9893847 chr17:489043 C/G cg13332499 chr17:408570 NA -0.37 -6.44 -0.33 4.08e-10 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); LUSC cis rs2580764 0.566 rs2968795 chr2:55287989 G/A cg20993754 chr2:55226987 RTN4 -0.36 -5.92 -0.31 8.2e-9 Mean platelet volume; LUSC cis rs6867032 0.834 rs10043083 chr5:1995687 C/G cg26168224 chr5:2018326 NA -0.73 -12.57 -0.57 6.2e-30 Gut microbiome composition (winter); LUSC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg26116260 chr4:7069785 GRPEL1 1.14 16.81 0.68 2.21e-46 Monocyte percentage of white cells; LUSC cis rs78456975 1.000 rs72778004 chr2:1571892 T/A cg12573674 chr2:1569213 NA -0.55 -6.13 -0.32 2.44e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs34421088 0.560 rs1478898 chr8:11395079 G/A cg27411982 chr8:10470053 RP1L1 -0.39 -6.23 -0.32 1.38e-9 Neuroticism; LUSC cis rs71403859 0.502 rs35394108 chr16:71540639 T/C cg08717414 chr16:71523259 ZNF19 -0.72 -8.57 -0.42 3.89e-16 Post bronchodilator FEV1; LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6012953 0.874 rs1885176 chr20:49175289 C/T cg13958625 chr20:49123093 NA -0.26 -5.76 -0.3 1.91e-8 Vitiligo; LUSC cis rs9486715 0.838 rs9386576 chr6:96954717 C/T cg06623918 chr6:96969491 KIAA0776 0.94 17.57 0.69 2.21e-49 Headache; LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.81 -0.43 6.75e-17 Platelet count; LUSC trans rs9944715 1.000 rs4890634 chr18:43854259 C/T cg01718231 chr17:29326311 RNF135 -0.53 -7.4 -0.38 1.11e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.14 -0.49 3.1e-21 Obesity-related traits; LUSC cis rs9814567 0.964 rs4974480 chr3:134178562 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.44 -0.56 1.94e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4891159 0.584 rs690397 chr18:74117767 C/T cg24786174 chr18:74118243 ZNF516 0.97 21.55 0.76 3.54e-65 Longevity; LUSC cis rs5758511 0.680 rs5758686 chr22:42655377 G/T cg12850546 chr22:42539477 CYP2D7P1 -0.46 -5.66 -0.3 3.18e-8 Birth weight; LUSC cis rs6942756 0.758 rs13226649 chr7:128977598 C/T cg02491457 chr7:128862824 NA -0.48 -7.17 -0.37 4.71e-12 White matter hyperintensity burden; LUSC cis rs1728785 1.000 rs1749791 chr16:68572347 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs782590 0.818 rs2627782 chr2:55825352 A/G cg03859395 chr2:55845619 SMEK2 0.81 14.18 0.61 4.69e-36 Metabolic syndrome; LUSC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg18190219 chr22:46762943 CELSR1 -0.48 -6.02 -0.31 4.53e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs10752881 1.000 rs12753817 chr1:182970337 A/T ch.1.3577855R chr1:183094577 LAMC1 0.66 10.29 0.49 9.3e-22 Colorectal cancer; LUSC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.96 -0.36 1.83e-11 Total body bone mineral density; LUSC cis rs7937682 0.889 rs7926485 chr11:111536670 G/A cg09085632 chr11:111637200 PPP2R1B -1.11 -18.45 -0.71 6.86e-53 Primary sclerosing cholangitis; LUSC cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 12.63 0.57 3.84e-30 Chronic sinus infection; LUSC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg01191920 chr7:158217561 PTPRN2 -0.54 -10.76 -0.51 2.29e-23 Obesity-related traits; LUSC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg26850624 chr5:429559 AHRR -0.43 -8.43 -0.42 1.08e-15 Cystic fibrosis severity; LUSC cis rs4268898 0.552 rs11125455 chr2:24374557 C/G cg06627628 chr2:24431161 ITSN2 0.5 7.0 0.36 1.39e-11 Asthma; LUSC cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.18 -0.45 4.78e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg08470875 chr2:26401718 FAM59B -0.72 -9.37 -0.46 1.1e-18 Gut microbiome composition (summer); LUSC trans rs2727020 0.617 rs1917311 chr11:49422665 C/T cg15704280 chr7:45808275 SEPT13 -1.1 -21.26 -0.76 4.93e-64 Coronary artery disease; LUSC cis rs9420 0.528 rs11229080 chr11:57399511 T/C cg23127183 chr11:57508653 C11orf31 -0.46 -6.46 -0.33 3.73e-10 Schizophrenia; LUSC cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg26647111 chr11:31128758 NA -0.43 -6.12 -0.32 2.58e-9 Red blood cell count; LUSC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg11301795 chr4:187892539 NA -0.81 -15.84 -0.66 1.49e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs2797160 0.935 rs6940748 chr6:125994080 C/T cg05901451 chr6:126070800 HEY2 -0.58 -8.78 -0.43 8.6e-17 Endometrial cancer; LUSC cis rs950027 0.620 rs1049518 chr15:45653367 G/A cg14582100 chr15:45693742 SPATA5L1 0.46 8.62 0.43 2.7e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg14440974 chr22:39074834 NA -0.35 -5.89 -0.31 9.41e-9 Menopause (age at onset); LUSC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.15 -0.49 2.8e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs886126 1.000 rs10082818 chr12:111663177 C/G cg10833066 chr12:111807467 FAM109A 0.4 6.28 0.33 1.03e-9 Coronary heart disease; LUSC cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg00530320 chr1:46809349 NSUN4 0.56 8.28 0.41 3.01e-15 Menopause (age at onset); LUSC cis rs8141529 0.764 rs8137969 chr22:29228484 G/C cg02153584 chr22:29168773 CCDC117 0.66 10.61 0.5 7.45e-23 Lymphocyte counts; LUSC cis rs17095355 1.000 rs56273398 chr10:111708183 C/T cg00817464 chr10:111662876 XPNPEP1 -0.67 -8.11 -0.41 9.41e-15 Biliary atresia; LUSC cis rs72781680 1.000 rs72796328 chr2:24141343 A/G cg20701182 chr2:24300061 SF3B14 0.77 7.73 0.39 1.25e-13 Lymphocyte counts; LUSC cis rs2011503 0.941 rs10403273 chr19:19372968 C/G cg11244672 chr19:19639970 YJEFN3 -0.52 -6.49 -0.33 3.05e-10 Bipolar disorder; LUSC cis rs9457247 0.756 rs1811123 chr6:167403443 T/C cg25258033 chr6:167368657 RNASET2 0.46 7.56 0.38 3.94e-13 Crohn's disease; LUSC cis rs7106204 0.609 rs34102968 chr11:24304149 C/T ch.11.24196551F chr11:24239977 NA 0.69 5.68 0.3 2.86e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs3770081 0.590 rs34522092 chr2:86208305 G/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.03 -6.6 -0.34 1.57e-10 Facial emotion recognition (sad faces); LUSC cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg23649088 chr2:200775458 C2orf69 -0.56 -6.69 -0.34 9.64e-11 Schizophrenia; LUSC trans rs17685 0.753 rs1637037 chr7:75692927 C/T cg19862616 chr7:65841803 NCRNA00174 1.12 19.83 0.74 2.22e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.06 0.48 5.86e-21 Electroencephalogram traits; LUSC cis rs4443100 0.535 rs13055979 chr22:23474085 C/T cg21100191 chr22:23484243 RTDR1 0.67 8.73 0.43 1.22e-16 Serum parathyroid hormone levels; LUSC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg06481639 chr22:41940642 POLR3H 0.51 5.93 0.31 7.37e-9 Vitiligo; LUSC cis rs9487051 0.735 rs1260594 chr6:109519891 A/C cg01475377 chr6:109611718 NA -0.36 -6.18 -0.32 1.9e-9 Reticulocyte fraction of red cells; LUSC cis rs7428496 0.510 rs13072355 chr3:142300006 G/A cg16271453 chr3:142027066 XRN1 -0.48 -8.13 -0.41 8.33e-15 Mean corpuscular hemoglobin; LUSC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs11098499 0.754 rs12506487 chr4:120271361 T/G cg09307838 chr4:120376055 NA 0.62 9.47 0.46 5.25e-19 Corneal astigmatism; LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg19318889 chr4:1322082 MAEA 0.47 7.87 0.4 5.07e-14 Longevity; LUSC cis rs12760731 0.720 rs10913553 chr1:178423062 G/C cg00404053 chr1:178313656 RASAL2 0.59 6.28 0.33 1.02e-9 Obesity-related traits; LUSC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.69 0.5 3.9e-23 Schizophrenia; LUSC trans rs7944735 0.767 rs1017875 chr11:47999218 C/T cg03929089 chr4:120376271 NA 0.59 6.25 0.32 1.26e-9 Intraocular pressure; LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.11e-9 Menopause (age at onset); LUSC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg06873352 chr17:61820015 STRADA 0.56 8.68 0.43 1.83e-16 Height; LUSC cis rs921968 0.509 rs7571743 chr2:219352572 C/T cg02176678 chr2:219576539 TTLL4 0.73 14.21 0.61 3.48e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg02951883 chr7:2050386 MAD1L1 -0.4 -6.86 -0.35 3.34e-11 Bipolar disorder and schizophrenia; LUSC cis rs9560113 1.000 rs9555809 chr13:112181401 T/C cg14154082 chr13:112174009 NA 0.38 7.88 0.4 4.53e-14 Menarche (age at onset); LUSC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.09 -0.4 1.1e-14 Axial length; LUSC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg05313129 chr8:58192883 C8orf71 -0.5 -6.86 -0.35 3.28e-11 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9788721 0.902 rs951266 chr15:78878541 C/T cg18825076 chr15:78729989 IREB2 -0.49 -7.85 -0.39 5.87e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9325144 0.510 rs7952795 chr12:38720686 C/T cg26384229 chr12:38710491 ALG10B 0.59 9.27 0.45 2.44e-18 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.31 -0.41 2.42e-15 Gut microbiome composition (summer); LUSC cis rs4808199 0.739 rs2240117 chr19:19418916 C/T cg03709012 chr19:19516395 GATAD2A 0.92 9.41 0.46 8.51e-19 Nonalcoholic fatty liver disease; LUSC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg20243544 chr17:37824526 PNMT 0.5 7.2 0.37 4.09e-12 Asthma; LUSC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg19920283 chr7:105172520 RINT1 0.59 6.08 0.32 3.38e-9 Bipolar disorder (body mass index interaction); LUSC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.47 6.83 0.35 3.92e-11 Eosinophil percentage of white cells; LUSC cis rs11039100 0.527 rs968991 chr11:5783816 G/A cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg09267113 chr7:98030324 BAIAP2L1 0.38 5.72 0.3 2.39e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs4903604 0.505 rs11623595 chr14:78037547 A/G cg18872420 chr14:78023429 SPTLC2 0.38 5.81 0.3 1.47e-8 Gut microbiome composition (winter); LUSC cis rs1322512 0.917 rs2623946 chr6:152962073 C/G cg27316956 chr6:152958899 SYNE1 -0.36 -6.22 -0.32 1.51e-9 Tonometry; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03486307 chr16:86597223 NA -0.45 -6.27 -0.32 1.14e-9 Hepatitis; LUSC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg07936489 chr17:37558343 FBXL20 -0.69 -9.54 -0.46 3.22e-19 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.21 0.37 3.79e-12 Alzheimer's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11282556 chr22:28314999 PITPNB;LOC284900 -0.44 -6.57 -0.34 1.91e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6815814 0.861 rs12233670 chr4:38787216 C/T cg06935464 chr4:38784597 TLR10 0.45 5.98 0.31 5.86e-9 Breast cancer; LUSC cis rs11098499 0.820 rs13128602 chr4:120459366 C/T cg09307838 chr4:120376055 NA -0.75 -11.04 -0.52 2.34e-24 Corneal astigmatism; LUSC cis rs611744 0.647 rs615233 chr8:109254262 C/T cg18478394 chr8:109455254 TTC35 0.41 6.29 0.33 9.7e-10 Dupuytren's disease; LUSC cis rs9314323 0.862 rs7813520 chr8:26263260 C/T cg11498726 chr8:26250323 BNIP3L -0.44 -6.43 -0.33 4.45e-10 Red cell distribution width; LUSC cis rs500891 0.553 rs7745251 chr6:84171756 G/T cg08257003 chr6:84140564 ME1 -0.27 -6.27 -0.32 1.09e-9 Platelet-derived growth factor BB levels; LUSC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.91 -18.94 -0.72 7.49e-55 Birth weight; LUSC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.47 7.29 0.37 2.24e-12 Colorectal cancer; LUSC cis rs11190604 1.000 rs2295773 chr10:102265815 A/G cg23241863 chr10:102295624 HIF1AN 0.5 6.15 0.32 2.17e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7674212 0.507 rs223471 chr4:103698786 G/C cg16532752 chr4:104119610 CENPE -0.41 -5.76 -0.3 1.86e-8 Type 2 diabetes; LUSC cis rs9322193 0.543 rs9371533 chr6:150210681 G/A cg07701084 chr6:150067640 NUP43 0.46 6.66 0.34 1.15e-10 Lung cancer; LUSC cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg15145296 chr3:125709740 NA -0.56 -6.32 -0.33 8.59e-10 Blood pressure (smoking interaction); LUSC cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg27279351 chr12:120934652 DYNLL1 0.63 8.35 0.42 1.8e-15 High light scatter reticulocyte count; LUSC cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg06022373 chr22:39101656 GTPBP1 0.7 10.84 0.51 1.14e-23 Menopause (age at onset); LUSC cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.56 0.38 3.9e-13 Colorectal cancer; LUSC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg23093090 chr10:104574429 C10orf26 -0.4 -7.3 -0.37 2.18e-12 Arsenic metabolism; LUSC trans rs6601450 0.522 rs7837979 chr8:10198534 C/T cg06636001 chr8:8085503 FLJ10661 0.42 6.21 0.32 1.57e-9 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs909002 0.720 rs4949459 chr1:32142354 G/T cg01639898 chr1:32083012 HCRTR1 0.26 6.07 0.32 3.5e-9 Intelligence (multi-trait analysis); LUSC cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg07424592 chr7:64974309 NA 0.65 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg01475377 chr6:109611718 NA -0.42 -7.39 -0.37 1.17e-12 Reticulocyte fraction of red cells; LUSC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg11657440 chr19:46296263 DMWD 0.87 16.5 0.67 3.87e-45 Coronary artery disease; LUSC cis rs12950390 0.893 rs11079789 chr17:45849715 A/G cg03474202 chr17:45855739 NA -0.3 -6.69 -0.34 9.5e-11 IgG glycosylation; LUSC cis rs1997103 1.000 rs6945937 chr7:55407140 C/T cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4474465 0.920 rs10899529 chr11:78207848 T/C cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs9457247 0.638 rs239933 chr6:167413230 A/G cg06454157 chr6:167490870 NA -0.24 -5.68 -0.3 2.89e-8 Crohn's disease; LUSC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg10792982 chr14:105748885 BRF1 0.5 9.28 0.45 2.2e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg17366294 chr4:99064904 C4orf37 0.61 10.9 0.51 7.28e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs11662586 0.517 rs7230837 chr18:77695384 A/T cg05926928 chr17:57297772 GDPD1 0.6 9.55 0.46 2.93e-19 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs3820928 0.874 rs13413235 chr2:227893863 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.57 -0.38 3.59e-13 Pulmonary function; LUSC cis rs7072216 0.763 rs3814142 chr10:100171104 C/G cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.83 12.6 0.57 4.58e-30 Cognitive test performance; LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg11843238 chr5:131593191 PDLIM4 0.46 7.74 0.39 1.19e-13 Acylcarnitine levels; LUSC cis rs9653442 1.000 rs11676922 chr2:100806940 T/A cg07810366 chr2:100720526 AFF3 -0.45 -7.91 -0.4 3.9e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9325144 0.560 rs2387924 chr12:38662883 A/G cg13010199 chr12:38710504 ALG10B -0.53 -8.1 -0.41 1.03e-14 Morning vs. evening chronotype; LUSC cis rs9329221 0.772 rs7824675 chr8:10243418 G/T cg21775007 chr8:11205619 TDH -0.5 -7.54 -0.38 4.57e-13 Neuroticism; LUSC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg22875332 chr1:76189707 ACADM 0.86 14.12 0.61 7.7e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.56 0.38 3.85e-13 Prudent dietary pattern; LUSC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg20503657 chr10:835505 NA 0.86 12.15 0.55 2.24e-28 Eosinophil percentage of granulocytes; LUSC cis rs977987 0.843 rs11860231 chr16:75385159 A/G cg03315344 chr16:75512273 CHST6 0.51 9.61 0.47 1.88e-19 Dupuytren's disease; LUSC cis rs13315871 1.000 rs13066269 chr3:58449244 T/C cg20936604 chr3:58311152 NA -0.72 -6.77 -0.35 5.83e-11 Cholesterol, total; LUSC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg11764359 chr7:65958608 NA 0.51 6.35 0.33 7.11e-10 Aortic root size; LUSC cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg13319975 chr6:146136371 FBXO30 0.48 7.19 0.37 4.4e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg26314531 chr2:26401878 FAM59B 0.69 8.92 0.44 3.21e-17 Gut microbiome composition (summer); LUSC cis rs400736 0.602 rs7553544 chr1:8165719 C/T cg25007680 chr1:8021821 PARK7 -0.48 -6.69 -0.34 9.47e-11 Response to antidepressants and depression; LUSC trans rs17685 0.697 rs2302437 chr7:75677016 G/A cg19862616 chr7:65841803 NCRNA00174 -1.14 -20.32 -0.74 2.42e-60 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4925386 0.808 rs1760073 chr20:60926106 A/G cg22601191 chr20:60968625 CABLES2 -0.39 -6.33 -0.33 8.08e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg07061783 chr6:25882402 NA 0.43 6.07 0.32 3.51e-9 Blood metabolite levels; LUSC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.91 0.4 3.86e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg15556689 chr8:8085844 FLJ10661 -0.85 -14.14 -0.61 6.94e-36 Schizophrenia; LUSC cis rs9486719 1.000 rs2179126 chr6:96871350 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3782089 1.000 rs3782089 chr11:65336819 C/T cg11802864 chr11:65308245 LTBP3 0.79 6.03 0.31 4.25e-9 Height; LUSC cis rs765787 0.530 rs11854294 chr15:45527996 A/G cg25801113 chr15:45476975 SHF 0.33 6.9 0.35 2.62e-11 Uric acid levels; LUSC cis rs2730245 0.527 rs2036582 chr7:158701708 A/T cg24397884 chr7:158709396 WDR60 0.55 6.23 0.32 1.44e-9 Height; LUSC trans rs6600671 1.000 rs2319969 chr1:121207335 A/G cg00646200 chr1:148855367 NA 0.47 7.5 0.38 5.94e-13 Hip geometry; LUSC cis rs9287719 0.615 rs12613769 chr2:10742290 C/T cg00105475 chr2:10696890 NA 0.34 5.75 0.3 2.03e-8 Prostate cancer; LUSC cis rs2797160 0.935 rs12717178 chr6:126016499 G/A cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.96e-16 Endometrial cancer; LUSC cis rs56399783 0.901 rs73033403 chr7:2877941 G/A cg19731401 chr7:2775893 GNA12 0.7 9.38 0.46 1.03e-18 Childhood ear infection; LUSC cis rs68170813 0.559 rs74745121 chr7:106958037 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC cis rs10761482 0.859 rs2219533 chr10:62094914 G/C cg18175470 chr10:62150864 ANK3 -0.45 -6.71 -0.34 8.5e-11 Schizophrenia; LUSC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg02772935 chr3:125709198 NA -0.47 -5.67 -0.3 3.15e-8 Blood pressure (smoking interaction); LUSC cis rs2463822 1.000 rs2463821 chr11:62111662 T/C cg06239285 chr11:62104954 ASRGL1 0.96 10.41 0.49 3.72e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -16.59 -0.67 1.66e-45 Gut microbiome composition (summer); LUSC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.24 -0.37 3.09e-12 Alzheimer's disease (late onset); LUSC cis rs17539620 0.628 rs62432729 chr6:154830044 T/C cg20019720 chr6:154832845 CNKSR3 0.63 8.58 0.43 3.6e-16 Lipoprotein (a) levels; LUSC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs6696846 0.765 rs4394715 chr1:205108393 T/G cg21643547 chr1:205240462 TMCC2 -0.41 -7.63 -0.39 2.49e-13 Red blood cell count; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg18876405 chr7:65276391 NA 0.55 8.99 0.44 1.88e-17 Calcium levels; LUSC cis rs11648785 0.747 rs12920767 chr16:90094570 A/G cg16611967 chr16:90144006 NA 0.42 5.64 0.3 3.56e-8 Tanning; LUSC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg16049864 chr8:95962084 TP53INP1 0.41 7.01 0.36 1.3e-11 Type 2 diabetes; LUSC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg05585544 chr11:47624801 NA -0.42 -7.36 -0.37 1.45e-12 Subjective well-being; LUSC cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg10523860 chr14:103875565 MARK3 -0.36 -5.78 -0.3 1.72e-8 Body mass index; LUSC cis rs3096299 0.679 rs3102338 chr16:89442250 C/G cg02187348 chr16:89574699 SPG7 0.51 7.59 0.38 3.2e-13 Multiple myeloma (IgH translocation); LUSC cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg17063962 chr7:91808500 NA 0.6 9.45 0.46 5.98e-19 Breast cancer; LUSC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 5.67 0.3 3.05e-8 Hip circumference adjusted for BMI; LUSC cis rs10876993 0.890 rs810204 chr12:58075733 T/C cg15848620 chr12:58087721 OS9 -0.56 -8.04 -0.4 1.62e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs9399135 0.967 rs1041480 chr6:135373076 G/T cg22676075 chr6:135203613 NA 0.46 7.13 0.36 6.1e-12 Red blood cell count; LUSC cis rs2204008 0.558 rs66545149 chr12:38204694 A/G cg13010199 chr12:38710504 ALG10B 0.7 10.59 0.5 8.81e-23 Bladder cancer; LUSC trans rs311904 0.793 rs4776427 chr15:69337180 A/C cg07092097 chr10:88720025 SNCG -0.64 -6.15 -0.32 2.2e-9 Obesity-related traits; LUSC cis rs12594515 1.000 rs7172161 chr15:45990780 A/G cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.29e-31 Prudent dietary pattern; LUSC cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg00898013 chr13:113819073 PROZ -0.56 -8.48 -0.42 7.28e-16 Platelet distribution width; LUSC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.36 -0.37 1.42e-12 Reticulocyte count; LUSC trans rs6600671 1.000 rs4844616 chr1:121171208 A/G cg00646200 chr1:148855367 NA 0.43 6.77 0.35 5.68e-11 Hip geometry; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg00106254 chr7:1943704 MAD1L1 -0.41 -5.94 -0.31 7.22e-9 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg00933542 chr6:150070202 PCMT1 -0.31 -6.57 -0.34 1.89e-10 Lung cancer; LUSC cis rs2806561 0.765 rs668234 chr1:23515467 G/A cg19743168 chr1:23544995 NA 0.4 7.89 0.4 4.45e-14 Height; LUSC cis rs9300255 0.506 rs61388686 chr12:123810873 G/A cg05973401 chr12:123451056 ABCB9 0.55 8.05 0.4 1.5e-14 Neutrophil percentage of white cells; LUSC cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg22676075 chr6:135203613 NA -0.5 -7.88 -0.4 4.81e-14 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg11871910 chr12:69753446 YEATS4 0.94 17.4 0.69 1.05e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg17143192 chr8:8559678 CLDN23 0.63 9.03 0.44 1.37e-17 Obesity-related traits; LUSC cis rs6964587 0.900 rs11984136 chr7:91766953 T/C cg17063962 chr7:91808500 NA 0.59 9.49 0.46 4.59e-19 Breast cancer; LUSC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg07701084 chr6:150067640 NUP43 0.57 8.66 0.43 1.98e-16 Lung cancer; LUSC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg03929089 chr4:120376271 NA -0.94 -15.05 -0.64 2.01e-39 Coronary artery disease; LUSC cis rs6089584 1.000 rs3787424 chr20:60559219 G/A cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.46e-9 Body mass index; LUSC cis rs9329221 0.527 rs6989657 chr8:10330873 C/G cg27411982 chr8:10470053 RP1L1 0.44 6.81 0.35 4.56e-11 Neuroticism; LUSC trans rs10432489 0.708 rs12328545 chr2:181771545 T/A cg16818443 chr4:2965195 GRK4;NOP14 0.82 6.01 0.31 4.74e-9 QT interval; LUSC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg14664628 chr15:75095509 CSK -0.55 -8.01 -0.4 1.97e-14 Breast cancer; LUSC cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.44 -8.22 -0.41 4.65e-15 Monocyte percentage of white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26868354 chr6:35699952 LOC285847 -0.39 -6.09 -0.32 3.18e-9 Electrocardiographic conduction measures; LUSC trans rs61931739 0.534 rs11053049 chr12:34164537 T/C cg13010199 chr12:38710504 ALG10B 0.55 8.49 0.42 6.68e-16 Morning vs. evening chronotype; LUSC cis rs9486719 0.947 rs11755945 chr6:96908038 G/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.81e-20 Migraine;Coronary artery disease; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg21280719 chr6:42927975 GNMT -0.31 -7.84 -0.39 6.14e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9297145 0.565 rs12705030 chr7:98765041 A/G cg05967295 chr7:98741636 SMURF1 -0.64 -10.0 -0.48 8.98e-21 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs9788682 1.000 rs12438181 chr15:78812098 G/A cg18825076 chr15:78729989 IREB2 0.47 6.37 0.33 6.15e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7903847 0.642 rs11814021 chr10:99158386 A/G cg08345082 chr10:99160200 RRP12 -0.35 -7.04 -0.36 1.12e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg07936489 chr17:37558343 FBXL20 0.72 9.96 0.48 1.28e-20 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg03806693 chr22:41940476 POLR3H -1.02 -13.77 -0.6 1.74e-34 Crohn's disease;Inflammatory bowel disease; LUSC cis rs11785693 0.866 rs11782170 chr8:4976942 A/G cg26367366 chr8:4980734 NA -0.67 -7.55 -0.38 4.18e-13 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg02534363 chr3:47050950 NBEAL2 0.36 5.77 0.3 1.84e-8 Colorectal cancer; LUSC cis rs8078723 0.630 rs60137005 chr17:38129996 A/T cg17344932 chr17:38183730 MED24;SNORD124 -0.53 -8.92 -0.44 3.14e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2274273 0.624 rs7147247 chr14:55777713 A/T cg04306507 chr14:55594613 LGALS3 0.47 9.5 0.46 4.28e-19 Protein biomarker; LUSC cis rs16867321 1.000 rs16867330 chr2:181446202 T/G cg23363182 chr2:181467187 NA -0.43 -5.91 -0.31 8.31e-9 Obesity; LUSC cis rs7739264 0.564 rs2223361 chr6:19790809 C/T cg02404759 chr6:19790362 NA -0.44 -6.93 -0.35 2.2e-11 Endometriosis; LUSC cis rs7923609 0.902 rs10822158 chr10:65094383 A/G cg01631684 chr10:65280961 REEP3 -0.41 -6.43 -0.33 4.53e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs2439831 0.867 rs3213990 chr15:43670226 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.88 9.5 0.46 4.21e-19 Lung cancer in ever smokers; LUSC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg06640241 chr16:89574553 SPG7 0.73 10.13 0.48 3.42e-21 Multiple myeloma (IgH translocation); LUSC cis rs8114671 0.562 rs2064454 chr20:33496169 C/T cg08999081 chr20:33150536 PIGU 0.33 5.77 0.3 1.8e-8 Height; LUSC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg11102782 chr19:18549136 ISYNA1 -0.35 -6.52 -0.34 2.67e-10 Breast cancer; LUSC trans rs7746199 0.736 rs13212318 chr6:27688841 A/C cg06606381 chr12:133084897 FBRSL1 -0.94 -8.79 -0.43 8.32e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs10876993 0.890 rs1678539 chr12:58060359 A/G cg18357645 chr12:58087776 OS9 0.52 7.86 0.4 5.41e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs6681460 0.671 rs628655 chr1:67213573 T/G cg02459107 chr1:67143332 SGIP1 -0.48 -8.53 -0.42 5.3e-16 Presence of antiphospholipid antibodies; LUSC cis rs61863818 0.842 rs11189214 chr10:99181008 A/G cg20016023 chr10:99160130 RRP12 0.29 6.38 0.33 6e-10 Monocyte percentage of white cells; LUSC cis rs4663969 0.733 rs6741669 chr2:234653192 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.7 -0.39 1.5700000000000001e-13 Total bilirubin levels in HIV-1 infection; LUSC cis rs983392 0.591 rs3132886 chr11:60016387 T/A cg24026212 chr11:59952134 MS4A6A 0.37 6.32 0.33 8.18e-10 Alzheimer's disease (late onset); LUSC cis rs1376303 0.558 rs12533180 chr7:32944132 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.68 5.94 0.31 7.35e-9 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg11366901 chr6:160182831 ACAT2 0.93 12.78 0.57 9.74e-31 Age-related macular degeneration (geographic atrophy); LUSC trans rs877282 0.898 rs12357995 chr10:765739 T/C cg13042288 chr15:90349979 ANPEP -0.47 -6.41 -0.33 4.97e-10 Uric acid levels; LUSC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.06 -0.48 5.7e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg23711669 chr6:146136114 FBXO30 -0.74 -13.4 -0.59 4.57e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg01849466 chr14:104193079 ZFYVE21 -0.59 -9.63 -0.47 1.6e-19 Schizophrenia; LUSC cis rs7804356 1.000 rs73067472 chr7:26855959 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs16867335 0.625 rs7573877 chr2:181478111 A/G cg23363182 chr2:181467187 NA -0.62 -9.58 -0.46 2.34e-19 Survival in rectal cancer; LUSC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.24 0.41 3.98e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs1559088 0.600 rs10423965 chr19:33600319 T/G cg17764715 chr19:33622953 WDR88 0.59 8.81 0.43 6.71e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg22875332 chr1:76189707 ACADM -0.4 -5.97 -0.31 5.93e-9 Daytime sleep phenotypes; LUSC cis rs6964587 0.839 rs10808086 chr7:91447515 T/C cg22709100 chr7:91322751 NA 0.48 6.98 0.36 1.59e-11 Breast cancer; LUSC cis rs9811920 0.809 rs4928235 chr3:99706870 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -7.16 -0.36 5.02e-12 Axial length; LUSC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg09904177 chr6:26538194 HMGN4 0.47 7.47 0.38 7.28e-13 Schizophrenia; LUSC cis rs11690935 0.959 rs66835971 chr2:172677459 G/A cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.65 -0.63 6.79e-38 Schizophrenia; LUSC cis rs10992471 0.528 rs1924243 chr9:95224847 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.22 -0.32 1.49e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6952809 0.532 rs6953297 chr7:2440874 C/G cg23289794 chr7:2394357 EIF3B -0.73 -9.74 -0.47 6.8e-20 Multiple sclerosis; LUSC trans rs7726839 0.561 rs72703044 chr5:579737 G/A cg25482853 chr8:67687455 SGK3 1.04 15.58 0.65 1.6e-41 Obesity-related traits; LUSC cis rs12286929 0.556 rs11605461 chr11:115053011 C/T cg04055981 chr11:115044050 NA -0.43 -7.75 -0.39 1.12e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg02820040 chr2:241836501 C2orf54 0.27 5.7 0.3 2.62e-8 Urinary metabolites; LUSC cis rs7107174 0.892 rs10899482 chr11:78060081 A/C cg02023728 chr11:77925099 USP35 0.43 6.53 0.34 2.41e-10 Testicular germ cell tumor; LUSC cis rs6500602 0.727 rs6500607 chr16:4503631 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.53 7.08 0.36 8.57e-12 Schizophrenia; LUSC cis rs4319547 0.661 rs10773172 chr12:122939655 G/A cg23029597 chr12:123009494 RSRC2 -0.67 -8.74 -0.43 1.14e-16 Body mass index; LUSC cis rs9296092 0.560 rs3846854 chr6:33528466 T/C cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs8073060 0.963 rs35614987 chr17:33869466 A/C cg19694781 chr19:47549865 TMEM160 0.7 10.43 0.5 3.08e-22 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs9308433 0.529 rs1391553 chr1:214474119 T/C cg06198575 chr1:214491504 SMYD2 0.46 7.14 0.36 5.95e-12 IgG glycosylation; LUSC cis rs6500395 1.000 rs1106386 chr16:48593065 C/A cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9341808 0.538 rs613588 chr6:80978928 A/C cg08355045 chr6:80787529 NA -0.41 -7.01 -0.36 1.31e-11 Sitting height ratio; LUSC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg05425664 chr17:57184151 TRIM37 0.53 7.79 0.39 8.64e-14 Intelligence (multi-trait analysis); LUSC cis rs113835537 0.866 rs59566349 chr11:66365994 A/T cg24851651 chr11:66362959 CCS 0.52 6.41 0.33 5.01e-10 Airway imaging phenotypes; LUSC cis rs1949733 1.000 rs2631758 chr4:8495304 G/A cg11789530 chr4:8429930 ACOX3 -0.61 -9.47 -0.46 5.23e-19 Response to antineoplastic agents; LUSC cis rs7119038 0.774 rs11217038 chr11:118677355 G/A cg19308663 chr11:118741387 NA 0.36 6.47 0.33 3.49e-10 Sjögren's syndrome; LUSC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg18306943 chr3:40428807 ENTPD3 0.4 6.18 0.32 1.87e-9 Renal cell carcinoma; LUSC cis rs2288073 0.965 rs6545335 chr2:24422011 G/A cg06627628 chr2:24431161 ITSN2 -0.78 -11.39 -0.53 1.28e-25 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs4474465 1.000 rs7925034 chr11:78193242 A/G cg27205649 chr11:78285834 NARS2 -0.5 -5.88 -0.31 1.01e-8 Alzheimer's disease (survival time); LUSC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC cis rs977987 0.898 rs12918797 chr16:75493810 T/C cg03315344 chr16:75512273 CHST6 0.53 9.97 0.48 1.13e-20 Dupuytren's disease; LUSC cis rs75804782 0.641 rs72987321 chr2:239352765 T/G cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs11122272 0.735 rs2790884 chr1:231531932 A/G cg06096015 chr1:231504339 EGLN1 0.58 10.39 0.49 4.18e-22 Hemoglobin concentration; LUSC cis rs950027 0.620 rs1719246 chr15:45625479 T/A cg14582100 chr15:45693742 SPATA5L1 0.45 8.54 0.42 4.94e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg08680598 chr22:49984980 NA -0.34 -6.36 -0.33 6.69e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 6.03 0.31 4.35e-9 Rheumatoid arthritis; LUSC cis rs9309473 0.519 rs12991161 chr2:73871371 G/A cg20560298 chr2:73613845 ALMS1 0.46 6.93 0.35 2.16e-11 Metabolite levels; LUSC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg23422044 chr7:1970798 MAD1L1 0.59 6.7 0.34 9.02e-11 Bipolar disorder; LUSC cis rs7927592 0.913 rs7106010 chr11:68365212 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.73 -0.3 2.24e-8 Total body bone mineral density; LUSC cis rs7819412 0.740 rs11250119 chr8:11037034 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.79 -0.3 1.62e-8 Triglycerides; LUSC cis rs7236492 0.748 rs78531995 chr18:77198370 C/T cg15644404 chr18:77186268 NFATC1 -0.68 -7.62 -0.38 2.63e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg05776053 chr2:74358815 NA 0.47 7.39 0.37 1.17e-12 Gestational age at birth (maternal effect); LUSC cis rs7759001 0.817 rs1534936 chr6:27354195 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.78 0.3 1.73e-8 Glomerular filtration rate (creatinine); LUSC cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg14844989 chr11:31128820 NA -0.39 -6.02 -0.31 4.6e-9 Red blood cell count; LUSC cis rs7945705 0.776 rs11042069 chr11:8817315 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.57 10.83 0.51 1.21e-23 Hemoglobin concentration; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg23978390 chr7:1156363 C7orf50 -0.45 -6.46 -0.33 3.68e-10 Longevity;Endometriosis; LUSC cis rs7100689 0.622 rs1417221 chr10:82100428 G/A cg00277334 chr10:82204260 NA -0.57 -8.67 -0.43 1.9e-16 Post bronchodilator FEV1; LUSC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs11764590 0.694 rs7797112 chr7:2085165 T/C cg19629631 chr7:2060116 MAD1L1 -0.34 -5.68 -0.3 2.89e-8 Neuroticism; LUSC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg03161606 chr19:29218774 NA 0.61 9.29 0.45 2.07e-18 Methadone dose in opioid dependence; LUSC cis rs59698941 0.882 rs67414627 chr5:132258165 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs9611519 0.732 rs1883826 chr22:41703428 G/A cg03806693 chr22:41940476 POLR3H -0.63 -9.21 -0.45 3.59e-18 Neuroticism; LUSC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg12463550 chr7:65579703 CRCP -0.42 -5.98 -0.31 5.67e-9 Aortic root size; LUSC cis rs9326248 0.559 rs10892064 chr11:116896553 G/C cg11861562 chr11:117069780 TAGLN 0.32 6.2 0.32 1.64e-9 Blood protein levels; LUSC cis rs11168618 0.904 rs7136845 chr12:48907029 C/T cg24011408 chr12:48396354 COL2A1 0.4 6.31 0.33 8.92e-10 Adiponectin levels; LUSC cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.78 0.43 8.88e-17 Motion sickness; LUSC cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg20701182 chr2:24300061 SF3B14 0.87 11.34 0.53 1.97e-25 Lymphocyte counts; LUSC trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC trans rs7615952 0.546 rs2979307 chr3:125309574 C/T cg07211511 chr3:129823064 LOC729375 0.52 6.04 0.31 4.11e-9 Blood pressure (smoking interaction); LUSC cis rs6500395 1.000 rs2080508 chr16:48690665 G/C cg04672837 chr16:48644449 N4BP1 -0.46 -6.87 -0.35 3.2e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg09640425 chr7:158790006 NA -0.55 -8.41 -0.42 1.18e-15 Facial morphology (factor 20); LUSC cis rs600231 0.542 rs10896010 chr11:65246220 C/A cg17120908 chr11:65337727 SSSCA1 -0.61 -8.89 -0.44 3.89e-17 Bone mineral density; LUSC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg12311346 chr5:56204834 C5orf35 -0.84 -12.95 -0.58 2.23e-31 Initial pursuit acceleration; LUSC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs9925964 0.935 rs4527034 chr16:31131614 A/G cg02466173 chr16:30829666 NA -0.32 -5.96 -0.31 6.46e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg10792982 chr14:105748885 BRF1 0.49 8.47 0.42 7.68e-16 Mean platelet volume;Platelet distribution width; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02980416 chr19:40502895 ZNF546 -0.43 -6.42 -0.33 4.64e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4423214 0.559 rs7949129 chr11:71193135 G/C cg05163923 chr11:71159392 DHCR7 -0.67 -7.06 -0.36 9.6e-12 Vitamin D levels; LUSC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg12963246 chr6:28129442 ZNF389 0.41 6.48 0.33 3.33e-10 Parkinson's disease; LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.63 0.65 9.98e-42 Platelet count; LUSC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg26597838 chr10:835615 NA 0.97 13.35 0.59 7.23e-33 Eosinophil percentage of granulocytes; LUSC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg00599273 chr12:58146742 CDK4 0.31 5.8 0.3 1.51e-8 Multiple sclerosis; LUSC cis rs4595586 0.545 rs1319791 chr12:39372486 G/T cg26384229 chr12:38710491 ALG10B 0.53 7.42 0.38 9.66e-13 Morning vs. evening chronotype; LUSC cis rs713477 1.000 rs8014526 chr14:55885054 C/G cg04306507 chr14:55594613 LGALS3 -0.32 -6.47 -0.33 3.43e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs7178572 0.568 rs4886856 chr15:77510585 A/G cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs28647808 0.748 rs114667516 chr9:136258537 A/G cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs8060686 0.545 rs12596883 chr16:68172416 A/T cg27539214 chr16:67997921 SLC12A4 -0.59 -7.2 -0.37 3.99e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs6964587 1.000 rs12704635 chr7:91737324 T/G cg17063962 chr7:91808500 NA 0.6 9.36 0.46 1.17e-18 Breast cancer; LUSC cis rs3741151 0.686 rs7129990 chr11:73124441 A/G cg17517138 chr11:73019481 ARHGEF17 0.61 5.94 0.31 7.29e-9 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27114094 chr18:3262035 MYL12B -0.41 -6.15 -0.32 2.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs3857536 0.813 rs6455083 chr6:66935406 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC trans rs6582630 0.502 rs11514371 chr12:38306306 G/C cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs34638657 0.732 rs2911425 chr16:82203026 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.53 -0.34 2.4e-10 Lung adenocarcinoma; LUSC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg06634786 chr22:41940651 POLR3H -0.53 -6.44 -0.33 4.05e-10 Vitiligo; LUSC cis rs62458065 0.713 rs62463967 chr7:32498329 G/A cg20159608 chr7:32802032 NA -0.73 -9.16 -0.45 5.35e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs950169 0.922 rs11633534 chr15:85124642 C/T cg12863693 chr15:85201151 NMB 0.37 7.52 0.38 4.96e-13 Schizophrenia; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg04518342 chr5:131593106 PDLIM4 0.54 10.21 0.49 1.82e-21 Acylcarnitine levels; LUSC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg13206674 chr6:150067644 NUP43 0.62 10.12 0.48 3.66e-21 Lung cancer; LUSC cis rs7605827 0.930 rs13006997 chr2:15700872 T/C cg19274914 chr2:15703543 NA 0.46 8.64 0.43 2.43e-16 Educational attainment (years of education); LUSC cis rs7584330 0.826 rs7604315 chr2:238381729 C/G cg14458575 chr2:238380390 NA 0.73 12.14 0.55 2.51e-28 Prostate cancer; LUSC trans rs61931739 0.500 rs11053242 chr12:34511625 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.09 0.45 9.21e-18 Morning vs. evening chronotype; LUSC cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg26752003 chr8:145688521 CYHR1 0.45 7.26 0.37 2.8e-12 Age at first birth; LUSC cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg00409905 chr10:38381863 ZNF37A -0.36 -6.17 -0.32 2e-9 Extrinsic epigenetic age acceleration; LUSC cis rs7666738 0.546 rs3911415 chr4:98692401 T/A cg05340658 chr4:99064831 C4orf37 0.58 8.47 0.42 7.94e-16 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.909 rs1546502 chr4:120235898 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.69 0.39 1.62e-13 Corneal astigmatism; LUSC cis rs7267979 1.000 rs1888998 chr20:25291826 A/G cg03522245 chr20:25566470 NINL -0.36 -5.83 -0.3 1.33e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs1559088 0.948 rs7259333 chr19:33579128 T/C cg27124370 chr19:33622961 WDR88 0.59 7.69 0.39 1.64e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg08481491 chr3:125900108 ALDH1L1 -0.34 -6.79 -0.35 5.09e-11 Metabolite levels; LUSC cis rs367943 0.712 rs26966 chr5:112740434 T/C cg12552261 chr5:112820674 MCC 0.34 5.65 0.3 3.42e-8 Type 2 diabetes; LUSC trans rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.77 -0.35 5.94e-11 Brugada syndrome; LUSC cis rs6088813 1.000 rs1570004 chr20:33958253 A/T cg04508476 chr20:34239394 CPNE1;RBM12 0.36 5.93 0.31 7.4e-9 Height; LUSC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg13628971 chr7:2884303 GNA12 0.45 6.72 0.35 7.91e-11 Height; LUSC cis rs981844 1.000 rs72731669 chr4:154662464 G/A cg14289246 chr4:154710475 SFRP2 0.5 6.44 0.33 4.05e-10 Response to statins (LDL cholesterol change); LUSC cis rs3784262 1.000 rs3784262 chr15:58253106 T/C cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.77 -0.3 1.78e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs713587 0.719 rs58048722 chr2:25187825 C/T cg15423357 chr2:25149977 NA -0.37 -7.29 -0.37 2.3e-12 Body mass index in non-asthmatics; LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs36051895 0.623 rs10118434 chr9:5238460 A/G cg02405213 chr9:5042618 JAK2 -0.56 -8.44 -0.42 9.86e-16 Pediatric autoimmune diseases; LUSC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -6.3 -0.33 9.36e-10 Intelligence (multi-trait analysis); LUSC trans rs7818345 0.613 rs13261732 chr8:19330215 T/C cg07611933 chr16:2773245 NA -0.23 -6.08 -0.32 3.21e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg09796270 chr17:17721594 SREBF1 -0.45 -7.94 -0.4 3.09e-14 Total body bone mineral density; LUSC cis rs1385374 1.000 rs12311303 chr12:129301592 C/T cg09035930 chr12:129282057 SLC15A4 -0.63 -7.0 -0.36 1.45e-11 Systemic lupus erythematosus; LUSC cis rs4555082 0.957 rs8022526 chr14:105756485 A/G cg06808227 chr14:105710500 BRF1 -0.65 -9.89 -0.48 2.06e-20 Mean platelet volume;Platelet distribution width; LUSC trans rs11935423 0.825 rs28789770 chr4:100489821 C/G cg02164153 chr5:172068145 NEURL1B -0.47 -6.07 -0.32 3.51e-9 Gut microbiome composition (summer); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24859484 chr2:174830050 SP3 -0.4 -6.29 -0.33 9.67e-10 Triglycerides; LUSC cis rs6547741 1.000 rs6737921 chr2:27839107 T/C cg27432699 chr2:27873401 GPN1 0.8 14.94 0.63 5.09e-39 Oral cavity cancer; LUSC cis rs9796 0.558 rs7166205 chr15:41514733 A/G cg18705301 chr15:41695430 NDUFAF1 -0.5 -8.88 -0.44 4.17e-17 Menopause (age at onset); LUSC trans rs61931739 0.500 rs28692887 chr12:34457075 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.74 0.65 3.85e-42 Morning vs. evening chronotype; LUSC cis rs67981189 0.593 rs221924 chr14:71580778 G/A cg15816911 chr14:71606274 NA -0.33 -5.76 -0.3 1.93e-8 Schizophrenia; LUSC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg06641503 chr3:48959341 ARIH2 -0.38 -5.77 -0.3 1.86e-8 Parkinson's disease; LUSC cis rs6961069 0.935 rs819437 chr7:80223996 C/T cg04458919 chr7:80252533 CD36 -0.35 -6.53 -0.34 2.44e-10 Platelet count; LUSC cis rs10791097 0.547 rs1050078 chr11:130746146 T/C cg12179176 chr11:130786555 SNX19 0.83 14.38 0.62 7.71e-37 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg06634786 chr22:41940651 POLR3H 0.51 6.11 0.32 2.82e-9 Vitiligo; LUSC cis rs12701220 0.894 rs2141274 chr7:1034717 G/A cg26769984 chr7:1090371 C7orf50 0.71 10.06 0.48 5.5e-21 Bronchopulmonary dysplasia; LUSC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg11965913 chr1:205819406 PM20D1 0.45 6.28 0.33 1.03e-9 Parkinson's disease; LUSC cis rs951366 0.531 rs12047038 chr1:205718468 A/G cg24503407 chr1:205819492 PM20D1 -0.48 -6.36 -0.33 6.68e-10 Menarche (age at onset); LUSC cis rs2742417 0.609 rs11709306 chr3:45773732 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.25 -0.37 2.97e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.53 -8.11 -0.41 9.51e-15 Lymphocyte counts; LUSC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.55e-15 Developmental language disorder (linguistic errors); LUSC cis rs259282 0.605 rs66489063 chr19:33108959 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.66 9.84 0.47 3.07e-20 Schizophrenia; LUSC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg24531977 chr5:56204891 C5orf35 -0.91 -12.62 -0.57 4.11e-30 Initial pursuit acceleration; LUSC cis rs10887741 0.646 rs1358865 chr10:89432645 C/A cg13926569 chr10:89418898 PAPSS2 0.33 7.23 0.37 3.21e-12 Exercise (leisure time); LUSC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC cis rs8016982 0.855 rs10149681 chr14:81686319 G/A cg01989461 chr14:81687754 GTF2A1 0.55 8.29 0.41 2.75e-15 Schizophrenia; LUSC cis rs6722750 0.716 rs2037862 chr2:64416533 C/T cg22352474 chr2:64371530 PELI1 -0.53 -7.96 -0.4 2.76e-14 Neuroticism; LUSC cis rs4662945 0.525 rs10174479 chr2:130296287 A/C cg05962382 chr2:130345044 NA -0.36 -6.31 -0.33 9.06e-10 Response to cytidine analogues (gemcitabine); LUSC cis rs7100689 0.646 rs10466235 chr10:82149655 C/T cg01528321 chr10:82214614 TSPAN14 -0.81 -11.96 -0.55 1.14e-27 Post bronchodilator FEV1; LUSC cis rs12760731 0.641 rs12691479 chr1:178328754 G/A cg00404053 chr1:178313656 RASAL2 0.57 6.07 0.32 3.44e-9 Obesity-related traits; LUSC cis rs9322193 1.000 rs9377229 chr6:149928791 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -7.06 -0.36 9.55e-12 Lung cancer; LUSC cis rs2692947 0.666 rs7566050 chr2:96626030 T/C cg22654517 chr2:96458247 NA 0.32 6.22 0.32 1.52e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4499344 0.556 rs259217 chr19:33138368 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.93 13.73 0.6 2.52e-34 Mean platelet volume; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg27492928 chr17:11993871 MAP2K4 -0.38 -6.22 -0.32 1.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs686320 1.000 rs686320 chr11:65244538 G/C cg21890820 chr11:65308645 LTBP3 0.75 7.48 0.38 6.58e-13 Hip circumference adjusted for BMI; LUSC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg18850127 chr7:39170497 POU6F2 0.66 10.7 0.51 3.71e-23 IgG glycosylation; LUSC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg15335139 chr3:50242325 SLC38A3 -0.25 -5.64 -0.3 3.57e-8 Body mass index; LUSC cis rs1559088 1.000 rs1559088 chr19:33551061 C/T cg17764715 chr19:33622953 WDR88 0.57 7.59 0.38 3.29e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg21918786 chr6:109611834 NA 0.41 7.1 0.36 7.41e-12 Reticulocyte fraction of red cells; LUSC cis rs4654899 0.680 rs10916900 chr1:21239059 C/G cg01072550 chr1:21505969 NA -0.52 -7.65 -0.39 2.24e-13 Superior frontal gyrus grey matter volume; LUSC cis rs6701037 1.000 rs6702010 chr1:175123858 C/A cg17845761 chr1:175162550 KIAA0040 -0.31 -6.0 -0.31 5.07e-9 Alcohol dependence; LUSC cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg11266682 chr4:10021025 SLC2A9 -0.5 -8.92 -0.44 3.08e-17 Bone mineral density; LUSC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg18876405 chr7:65276391 NA 0.55 8.71 0.43 1.38e-16 Aortic root size; LUSC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.12 0.32 2.64e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10276381 1.000 rs10281214 chr7:28185544 G/C cg23620719 chr7:28220237 JAZF1 0.59 6.55 0.34 2.15e-10 Crohn's disease; LUSC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg26335602 chr6:28129616 ZNF389 0.43 5.75 0.3 1.98e-8 Depression; LUSC cis rs79839061 0.610 rs17781499 chr4:889384 C/A cg07828340 chr4:882639 GAK 1.03 10.42 0.5 3.42e-22 Intelligence (multi-trait analysis); LUSC trans rs57221529 0.709 rs72703090 chr5:598314 C/T cg11887960 chr12:57824829 NA 0.54 6.74 0.35 7.11e-11 Lung disease severity in cystic fibrosis; LUSC cis rs8170 0.603 rs3810204 chr19:17448660 T/C cg04749549 chr19:17459798 NA -0.34 -6.09 -0.32 3.11e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC trans rs10435719 0.902 rs11250179 chr8:11800332 C/T cg27411982 chr8:10470053 RP1L1 0.41 6.4 0.33 5.23e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.59 -0.34 1.73e-10 Bipolar disorder and schizophrenia; LUSC cis rs10089 1.000 rs3816006 chr5:127450581 T/A cg19767477 chr5:127420684 SLC12A2 -0.43 -5.87 -0.31 1.06e-8 Ileal carcinoids; LUSC trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg11887960 chr12:57824829 NA 0.58 7.13 0.36 6.16e-12 Lung disease severity in cystic fibrosis; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg10150615 chr22:24372951 LOC391322 -0.42 -6.86 -0.35 3.4e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg14784868 chr12:69753453 YEATS4 0.91 16.06 0.66 2.01e-43 Cerebrospinal fluid biomarker levels; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03352830 chr11:487213 PTDSS2 0.78 9.42 0.46 7.77e-19 Body mass index; LUSC cis rs10489202 1.000 rs7538251 chr1:168001752 C/G cg24449463 chr1:168025552 DCAF6 -0.62 -7.91 -0.4 3.71e-14 Schizophrenia; LUSC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg07256732 chr16:621771 PIGQ -0.35 -6.41 -0.33 4.98e-10 Height; LUSC trans rs9409565 0.787 rs11789704 chr9:97233408 C/T cg05679027 chr9:99775184 HIATL2 -0.47 -6.59 -0.34 1.73e-10 Colorectal cancer (alcohol consumption interaction); LUSC cis rs10489202 1.000 rs7523437 chr1:168029365 A/G cg24449463 chr1:168025552 DCAF6 -0.58 -7.26 -0.37 2.71e-12 Schizophrenia; LUSC cis rs61931739 0.500 rs7963282 chr12:34535255 A/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs9392556 0.829 rs659025 chr6:4119051 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.35 -6.0 -0.31 5.14e-9 Blood metabolite levels; LUSC cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg19812747 chr11:111475976 SIK2 0.5 6.7 0.34 8.87e-11 Primary sclerosing cholangitis; LUSC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg00990874 chr7:1149470 C7orf50 -0.5 -6.33 -0.33 7.99e-10 Bronchopulmonary dysplasia; LUSC trans rs953492 0.517 rs2247527 chr1:243309983 A/C cg25284624 chr1:224180302 NA 0.48 7.44 0.38 8.53e-13 Diastolic blood pressure; LUSC cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg13175981 chr1:150552382 MCL1 0.43 6.09 0.32 3.19e-9 Tonsillectomy; LUSC cis rs8072100 0.935 rs78551919 chr17:45626002 A/C cg25173405 chr17:45401733 C17orf57 0.37 5.9 0.31 8.79e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC cis rs1018836 0.828 rs7008172 chr8:91551613 C/T cg16814680 chr8:91681699 NA -0.69 -11.05 -0.52 2.13e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7824557 0.505 rs2736313 chr8:11086942 C/T cg21775007 chr8:11205619 TDH 0.52 7.86 0.4 5.17e-14 Retinal vascular caliber; LUSC cis rs10911363 0.659 rs6669960 chr1:183436577 C/G cg09173681 chr1:183549694 NCF2 -0.62 -11.1 -0.52 1.43e-24 Systemic lupus erythematosus; LUSC cis rs1728785 1.000 rs1645979 chr16:68603660 G/T cg02972257 chr16:68554789 NA -0.54 -6.74 -0.35 7.02e-11 Ulcerative colitis; LUSC cis rs9300255 0.602 rs2695476 chr12:123694206 T/C cg13010344 chr12:123464640 ARL6IP4 -0.48 -5.9 -0.31 8.74e-9 Neutrophil percentage of white cells; LUSC cis rs11690935 0.788 rs6715929 chr2:172877507 A/G cg13550731 chr2:172543902 DYNC1I2 -0.72 -11.66 -0.54 1.33e-26 Schizophrenia; LUSC cis rs6967385 0.560 rs7790370 chr7:12353523 G/C cg06484146 chr7:12443880 VWDE 0.5 7.42 0.38 1.01e-12 Response to taxane treatment (placlitaxel); LUSC trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.26 -0.37 2.7e-12 Monocyte count; LUSC cis rs710865 1.000 rs710865 chr1:19568972 A/G cg13387374 chr1:19411106 UBR4 0.44 6.42 0.33 4.62e-10 Brain structure; LUSC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg09491104 chr22:46646882 C22orf40 -0.7 -7.1 -0.36 7.44e-12 LDL cholesterol;Cholesterol, total; LUSC trans rs7493138 0.967 rs1951257 chr14:29008123 A/G cg10573181 chr4:170533618 NEK1 0.41 6.09 0.32 3.14e-9 Longevity; LUSC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg08219700 chr8:58056026 NA 0.47 6.24 0.32 1.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg22535103 chr8:58192502 C8orf71 -0.72 -7.42 -0.38 9.98e-13 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg07424592 chr7:64974309 NA 0.67 5.88 0.31 9.86e-9 Diabetic kidney disease; LUSC cis rs4819052 0.635 rs2838808 chr21:46621106 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.46 6.62 0.34 1.41e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg21724239 chr8:58056113 NA 0.85 9.05 0.44 1.18e-17 Developmental language disorder (linguistic errors); LUSC cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg24596788 chr1:163392923 NA -0.42 -7.17 -0.37 4.99e-12 Motion sickness; LUSC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg25019033 chr10:957182 NA -0.5 -6.41 -0.33 4.95e-10 Eosinophil percentage of granulocytes; LUSC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg00857998 chr1:205179979 DSTYK 0.64 9.73 0.47 7.18e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9467773 1.000 rs9461271 chr6:26554968 G/A cg09904177 chr6:26538194 HMGN4 0.75 14.04 0.61 1.66e-35 Intelligence (multi-trait analysis); LUSC trans rs6598955 0.671 rs11247901 chr1:26612693 T/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.86 -0.44 4.74e-17 Obesity-related traits; LUSC cis rs7584330 0.910 rs72620830 chr2:238396985 C/T cg16989719 chr2:238392110 NA -0.43 -7.34 -0.37 1.61e-12 Prostate cancer; LUSC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg08109568 chr15:31115862 NA 0.74 11.21 0.52 5.84e-25 Huntington's disease progression; LUSC trans rs11098499 0.820 rs6829903 chr4:120506884 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.7 0.34 8.95e-11 Corneal astigmatism; LUSC cis rs908922 0.651 rs10888493 chr1:152503913 G/A cg20991723 chr1:152506922 NA 0.53 9.93 0.48 1.56e-20 Hair morphology; LUSC cis rs6964587 0.773 rs59242586 chr7:91918145 A/G cg17063962 chr7:91808500 NA 0.53 7.63 0.39 2.54e-13 Breast cancer; LUSC cis rs66887589 0.592 rs11731571 chr4:120221185 G/A cg24375607 chr4:120327624 NA 0.49 7.36 0.37 1.42e-12 Diastolic blood pressure; LUSC cis rs713587 0.713 rs4665276 chr2:25213333 C/T cg01884057 chr2:25150051 NA -0.38 -8.46 -0.42 8.22e-16 Body mass index in non-asthmatics; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11123972 chr11:68228042 SAPS3 -0.4 -6.06 -0.31 3.75e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs61931739 0.591 rs10743834 chr12:33916129 A/C cg13010199 chr12:38710504 ALG10B 0.41 6.11 0.32 2.76e-9 Morning vs. evening chronotype; LUSC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg12927641 chr6:109611667 NA -0.41 -7.04 -0.36 1.08e-11 Reticulocyte fraction of red cells; LUSC cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs1256061 0.603 rs1256041 chr14:64738029 A/G cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs6076065 0.723 rs6083110 chr20:23373674 C/T cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg16989719 chr2:238392110 NA -0.48 -7.68 -0.39 1.77e-13 Prostate cancer; LUSC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC trans rs4332037 0.539 rs11762636 chr7:2061111 C/A cg25206134 chr2:45395956 NA 0.62 7.23 0.37 3.24e-12 Bipolar disorder; LUSC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg08219700 chr8:58056026 NA 0.49 6.06 0.31 3.73e-9 Developmental language disorder (linguistic errors); LUSC trans rs11039798 0.588 rs11039781 chr11:48523085 T/G cg03929089 chr4:120376271 NA 0.61 6.5 0.34 2.97e-10 Axial length; LUSC cis rs3862435 0.764 rs2601200 chr15:90955177 C/T cg22089800 chr15:90895588 ZNF774 0.58 6.32 0.33 8.53e-10 Response to exercise (triglyceride level interaction); LUSC cis rs4865169 0.934 rs3796531 chr4:57850846 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.41 -6.24 -0.32 1.33e-9 Breast cancer; LUSC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg22875332 chr1:76189707 ACADM 0.85 15.67 0.65 6.91e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg19729930 chr2:74357872 NA 0.88 16.81 0.68 2.13e-46 Gestational age at birth (maternal effect); LUSC cis rs13082711 0.595 rs4973762 chr3:27364789 A/T cg02860705 chr3:27208620 NA 0.73 12.1 0.55 3.33e-28 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7103648 0.897 rs35032070 chr11:47408592 G/A cg20307385 chr11:47447363 PSMC3 0.92 15.86 0.66 1.26e-42 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg09263875 chr16:632152 PIGQ 0.71 13.3 0.59 1.12e-32 Height; LUSC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.0 0.52 3.23e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg08847533 chr14:75593920 NEK9 0.84 15.41 0.64 7.39e-41 Height; LUSC cis rs8028313 0.630 rs8035989 chr15:67965620 G/A cg05925327 chr15:68127851 NA -0.39 -6.1 -0.32 2.89e-9 Obesity; LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs2797160 1.000 rs9321050 chr6:126001568 A/G cg05901451 chr6:126070800 HEY2 -0.57 -8.56 -0.42 4.29e-16 Endometrial cancer; LUSC cis rs9549367 0.713 rs9577211 chr13:113830718 G/C cg00898013 chr13:113819073 PROZ -0.6 -8.82 -0.43 6.27e-17 Platelet distribution width; LUSC cis rs8060686 0.544 rs1124993 chr16:68114626 T/C cg26727032 chr16:67993705 SLC12A4 -0.42 -5.75 -0.3 1.99e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg01256987 chr12:42539512 GXYLT1 -0.45 -8.34 -0.42 1.97e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9300255 0.596 rs1568427 chr12:123738678 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.08 -0.32 3.26e-9 Neutrophil percentage of white cells; LUSC trans rs6582630 0.502 rs7312212 chr12:38274760 T/G cg06521331 chr12:34319734 NA -0.4 -6.27 -0.32 1.15e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg14196790 chr5:131705035 SLC22A5 -0.43 -6.99 -0.36 1.53e-11 Breast cancer;Mosquito bite size; LUSC cis rs950776 0.518 rs4243083 chr15:78833830 C/G cg06917634 chr15:78832804 PSMA4 -0.81 -14.43 -0.62 4.97e-37 Sudden cardiac arrest; LUSC cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg06784218 chr1:46089804 CCDC17 -0.47 -9.0 -0.44 1.72e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9814567 1.000 rs4309773 chr3:134277301 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.58 -0.6 9.2e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs7829975 0.573 rs7842359 chr8:8797078 T/G cg21775007 chr8:11205619 TDH -0.41 -6.22 -0.32 1.49e-9 Mood instability; LUSC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg04455712 chr21:45112962 RRP1B -0.44 -8.13 -0.41 8.72e-15 Mean corpuscular volume; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.62 10.14 0.49 3.07e-21 Lymphocyte counts; LUSC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1957429 0.901 rs1957435 chr14:65349697 G/A cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs9814567 1.000 rs9832785 chr3:134213070 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.77 -0.6 1.81e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7617773 0.780 rs35411187 chr3:48360017 C/G cg11946769 chr3:48343235 NME6 0.88 14.18 0.61 4.69e-36 Coronary artery disease; LUSC cis rs1577917 0.958 rs34230196 chr6:86526022 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs977987 0.843 rs12149063 chr16:75451758 G/A cg03315344 chr16:75512273 CHST6 0.48 8.93 0.44 3.01e-17 Dupuytren's disease; LUSC cis rs10266483 0.739 rs12671185 chr7:63793707 G/A cg24201672 chr7:64023550 ZNF680 0.44 5.8 0.3 1.5e-8 Response to statin therapy; LUSC cis rs6121246 0.559 rs6121172 chr20:30296095 A/C cg13852791 chr20:30311386 BCL2L1 0.93 14.46 0.62 3.86e-37 Mean corpuscular hemoglobin; LUSC trans rs4911259 0.552 rs13041458 chr20:31467376 G/T cg09781936 chr22:19749961 TBX1 -0.33 -5.95 -0.31 6.84e-9 Inflammatory bowel disease; LUSC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.05 -0.4 1.45e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs554111 0.634 rs12026318 chr1:21316623 T/C cg01072550 chr1:21505969 NA 0.41 6.28 0.32 1.05e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg06481639 chr22:41940642 POLR3H -0.52 -5.95 -0.31 6.8e-9 Vitiligo; LUSC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -5.99 -0.31 5.34e-9 Intelligence (multi-trait analysis); LUSC cis rs1403694 0.515 rs1622922 chr3:186449884 C/T cg12454167 chr3:186435060 KNG1 0.28 7.63 0.39 2.46e-13 Blood protein levels; LUSC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg03806693 chr22:41940476 POLR3H 0.94 13.74 0.6 2.27e-34 Vitiligo; LUSC cis rs11690935 0.550 rs6718013 chr2:172869185 A/G cg13550731 chr2:172543902 DYNC1I2 0.53 7.96 0.4 2.7e-14 Schizophrenia; LUSC cis rs981844 0.683 rs1037653 chr4:154749992 A/T cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC cis rs2562456 0.793 rs2562474 chr19:21646282 A/C cg00806126 chr19:22604979 ZNF98 0.39 6.01 0.31 4.87e-9 Pain; LUSC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg14558114 chr2:88469736 THNSL2 -0.76 -6.66 -0.34 1.15e-10 Plasma clusterin levels; LUSC trans rs853679 0.517 rs12174753 chr6:28042465 C/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.3e-9 Depression; LUSC cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg05283184 chr6:79620031 NA -0.46 -8.72 -0.43 1.36e-16 Intelligence (multi-trait analysis); LUSC trans rs208520 1.000 rs12209225 chr6:66996443 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 12.03 0.55 6.38e-28 Exhaled nitric oxide output; LUSC cis rs13031619 0.607 rs13001751 chr2:3695870 A/G cg25251562 chr2:3704773 ALLC -0.37 -6.56 -0.34 2.02e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs34734847 0.787 rs695948 chr12:121149596 A/G cg21892295 chr12:121157589 UNC119B -0.49 -8.96 -0.44 2.27e-17 Mean corpuscular volume; LUSC cis rs6163 0.508 rs11191381 chr10:104493444 C/T cg04362960 chr10:104952993 NT5C2 0.51 7.17 0.37 4.77e-12 Waist circumference;Hip circumference; LUSC cis rs826838 0.967 rs11168985 chr12:39045983 A/C cg13010199 chr12:38710504 ALG10B -0.67 -10.83 -0.51 1.27e-23 Heart rate; LUSC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg04287289 chr16:89883240 FANCA 0.78 6.24 0.32 1.29e-9 Skin colour saturation; LUSC cis rs7592578 0.508 rs10931451 chr2:191270888 G/A cg11845111 chr2:191398756 TMEM194B -0.68 -9.15 -0.45 5.95e-18 Diastolic blood pressure; LUSC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg11645453 chr3:52864694 ITIH4 0.34 7.87 0.4 5.04e-14 Electroencephalogram traits; LUSC cis rs2839186 0.872 rs13046834 chr21:47701485 T/C cg05896524 chr21:47604654 C21orf56 0.4 5.91 0.31 8.52e-9 Testicular germ cell tumor; LUSC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg25427524 chr10:38739819 LOC399744 -0.67 -12.11 -0.55 3.17e-28 Extrinsic epigenetic age acceleration; LUSC cis rs10197940 0.578 rs6718653 chr2:152346118 C/A cg19508488 chr2:152266495 RIF1 0.4 5.8 0.3 1.58e-8 Lung cancer; LUSC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg06637938 chr14:75390232 RPS6KL1 0.49 7.57 0.38 3.61e-13 Height; LUSC cis rs3730682 0.694 rs648383 chr18:51778993 G/C cg04730925 chr18:51795821 POLI 0.4 6.14 0.32 2.39e-9 Psoriasis; LUSC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg15649852 chr7:65879115 NA -0.41 -5.75 -0.3 2.05e-8 Aortic root size; LUSC cis rs2952156 0.920 rs2517959 chr17:37846512 A/T cg00129232 chr17:37814104 STARD3 -0.43 -6.25 -0.32 1.28e-9 Asthma; LUSC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg02423579 chr7:2872169 GNA12 -0.4 -6.34 -0.33 7.58e-10 Height; LUSC cis rs7818345 0.935 rs6990217 chr8:19276661 G/C cg11303988 chr8:19266685 CSGALNACT1 0.37 7.12 0.36 6.47e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg26384229 chr12:38710491 ALG10B 0.87 14.22 0.61 3.36e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg09491104 chr22:46646882 C22orf40 -0.64 -7.22 -0.37 3.64e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg08280861 chr8:58055591 NA -0.56 -6.2 -0.32 1.62e-9 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg00677455 chr12:58241039 CTDSP2 0.5 7.6 0.38 3.06e-13 Intelligence (multi-trait analysis); LUSC trans rs1997103 0.954 rs4947505 chr7:55409448 T/C cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9322817 0.691 rs2486143 chr6:105308593 A/G cg02098413 chr6:105308735 HACE1 0.27 5.76 0.3 1.92e-8 Thyroid stimulating hormone; LUSC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg01416388 chr22:39784598 NA -0.43 -7.21 -0.37 3.82e-12 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21908287 chr1:155225385 FAM189B 0.69 6.04 0.31 4.02e-9 Cognitive performance; LUSC cis rs6430585 0.583 rs4594504 chr2:136625113 A/C cg07169764 chr2:136633963 MCM6 1.24 19.67 0.73 9.29e-58 Corneal structure; LUSC trans rs6951245 1.000 rs77868187 chr7:1093968 A/C cg13565492 chr6:43139072 SRF -0.61 -6.4 -0.33 5.21e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7939886 0.688 rs11227290 chr11:55896577 A/G cg03929089 chr4:120376271 NA 0.74 6.19 0.32 1.74e-9 Myopia (pathological); LUSC trans rs7849782 0.967 rs10760799 chr9:104414056 G/T cg22914338 chr19:14376960 NA 0.25 6.13 0.32 2.48e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1003719 0.788 rs2835597 chr21:38466539 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC trans rs12902680 0.706 rs12439680 chr15:46528391 A/C cg04321580 chr8:143696133 ARC -0.42 -6.18 -0.32 1.83e-9 Neuroticism; LUSC cis rs10214930 0.560 rs42088 chr7:27701861 C/T cg22168087 chr7:27702803 HIBADH -0.46 -6.2 -0.32 1.63e-9 Hypospadias; LUSC cis rs1594829 0.500 rs4871973 chr8:26199883 A/G cg13160058 chr8:26243215 BNIP3L -0.33 -6.0 -0.31 5.09e-9 Height; LUSC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg23172400 chr8:95962367 TP53INP1 -0.31 -5.84 -0.3 1.23e-8 Type 2 diabetes; LUSC cis rs7264396 0.690 rs2425157 chr20:34419083 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -6.75 -0.35 6.45e-11 Total cholesterol levels; LUSC cis rs61931739 0.534 rs11053131 chr12:34282109 A/G cg06521331 chr12:34319734 NA -0.51 -8.93 -0.44 2.96e-17 Morning vs. evening chronotype; LUSC trans rs9291683 0.588 rs13133766 chr4:10019732 C/T cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Bone mineral density; LUSC cis rs2731664 0.765 rs2630766 chr5:176874941 A/C cg23176889 chr5:176863531 GRK6 -0.66 -13.67 -0.6 4.36e-34 Intelligence (multi-trait analysis); LUSC cis rs1003719 0.708 rs2000417 chr21:38502868 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs4820539 1.000 rs916584 chr22:23469433 A/G cg14186256 chr22:23484241 RTDR1 0.95 17.97 0.7 5.24e-51 Bone mineral density; LUSC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg18230493 chr5:56204884 C5orf35 -0.87 -13.11 -0.58 5.69e-32 Initial pursuit acceleration; LUSC cis rs2806561 0.729 rs649664 chr1:23324263 C/T cg19743168 chr1:23544995 NA -0.38 -7.94 -0.4 3.02e-14 Height; LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg11843238 chr5:131593191 PDLIM4 -0.49 -8.75 -0.43 1.09e-16 Acylcarnitine levels; LUSC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg19318889 chr4:1322082 MAEA 0.55 9.14 0.45 6.3e-18 Obesity-related traits; LUSC cis rs1775715 0.870 rs10827001 chr10:32229734 C/T cg26784012 chr10:32216390 ARHGAP12 0.41 6.81 0.35 4.63e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg06740227 chr12:86229804 RASSF9 0.37 5.84 0.3 1.27e-8 Major depressive disorder; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg24503407 chr1:205819492 PM20D1 -0.85 -15.77 -0.65 2.77e-42 Menarche (age at onset); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg08215925 chr3:71633214 FOXP1 0.43 6.68 0.34 1.01e-10 Triglycerides; LUSC cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg26446133 chr18:72167187 CNDP2 -0.84 -13.58 -0.6 9.18e-34 Refractive error; LUSC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg04287289 chr16:89883240 FANCA -0.43 -6.14 -0.32 2.3e-9 Vitiligo; LUSC cis rs2898290 0.622 rs1600250 chr8:11345425 A/C cg21775007 chr8:11205619 TDH -0.5 -7.54 -0.38 4.51e-13 Systolic blood pressure; LUSC trans rs7939886 0.920 rs11227372 chr11:55919682 C/A cg03929089 chr4:120376271 NA 0.77 6.12 0.32 2.62e-9 Myopia (pathological); LUSC cis rs11997175 0.574 rs4538830 chr8:33653741 C/G ch.8.33884649F chr8:33765107 NA 0.52 8.45 0.42 8.95e-16 Body mass index; LUSC cis rs243505 0.964 rs243517 chr7:148425915 T/A cg09806900 chr7:148480153 CUL1 -0.48 -6.94 -0.35 2.08e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9653442 0.527 rs4850923 chr2:100782256 A/C cg22139774 chr2:100720529 AFF3 -0.42 -7.27 -0.37 2.55e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg06634786 chr22:41940651 POLR3H 0.5 6.01 0.31 4.81e-9 Vitiligo; LUSC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg22800045 chr5:56110881 MAP3K1 0.77 9.5 0.46 4.11e-19 Initial pursuit acceleration; LUSC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg27432699 chr2:27873401 GPN1 -0.56 -8.36 -0.42 1.67e-15 Total body bone mineral density; LUSC trans rs9329221 0.537 rs13254175 chr8:9978772 C/T cg21775007 chr8:11205619 TDH 0.42 5.99 0.31 5.42e-9 Neuroticism; LUSC cis rs7264396 0.790 rs6058283 chr20:34216276 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.73 -0.47 7.04e-20 Total cholesterol levels; LUSC cis rs11608355 0.515 rs3742018 chr12:109949134 C/T cg05360138 chr12:110035743 NA 0.92 12.22 0.56 1.23e-28 Neuroticism; LUSC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg17385448 chr1:15911702 AGMAT 0.38 6.42 0.33 4.64e-10 Systolic blood pressure; LUSC cis rs12195417 0.563 rs607259 chr6:84217876 G/A cg08257003 chr6:84140564 ME1 -0.28 -6.55 -0.34 2.12e-10 Schizophrenia; LUSC cis rs1371867 0.846 rs1660327 chr8:101292206 A/C cg00191853 chr8:101177733 SPAG1 -0.41 -6.56 -0.34 2.08e-10 Atrioventricular conduction; LUSC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg02079420 chr8:82753780 SNX16 -0.41 -7.03 -0.36 1.13e-11 Diastolic blood pressure; LUSC cis rs12579753 0.827 rs7958100 chr12:82200782 G/A cg07988820 chr12:82153109 PPFIA2 -0.42 -6.04 -0.31 4.05e-9 Resting heart rate; LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs9790314 0.905 rs6774276 chr3:160941318 C/T cg04691961 chr3:161091175 C3orf57 -0.35 -5.92 -0.31 7.79e-9 Morning vs. evening chronotype; LUSC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg06656553 chr16:89960601 TCF25 -0.55 -5.66 -0.3 3.24e-8 Skin colour saturation; LUSC cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg00504896 chr12:9437009 LOC642846 -0.48 -7.63 -0.39 2.41e-13 Breast size; LUSC cis rs644799 0.625 rs1255177 chr11:95471495 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.58 8.86 0.44 4.85e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2637266 0.935 rs7477361 chr10:78393586 G/A cg18941641 chr10:78392320 NA 0.41 7.45 0.38 8.16e-13 Pulmonary function; LUSC cis rs7180079 1.000 rs12148898 chr15:64643691 T/C cg02848875 chr15:64387786 SNX1 0.4 5.64 0.3 3.54e-8 Monocyte count; LUSC trans rs2898290 0.540 rs12677146 chr8:11450737 C/G cg15556689 chr8:8085844 FLJ10661 -0.56 -8.65 -0.43 2.13e-16 Systolic blood pressure; LUSC cis rs12594515 1.000 rs12911309 chr15:45985719 G/C cg19682013 chr15:45996608 NA 0.38 5.75 0.3 2.03e-8 Waist circumference;Weight; LUSC cis rs921665 0.680 rs76494865 chr2:3191204 G/A cg16434511 chr2:3151078 NA -0.63 -6.83 -0.35 3.92e-11 World class endurance athleticism; LUSC cis rs2625529 0.824 rs12592044 chr15:72419115 A/G cg16672083 chr15:72433130 SENP8 -0.51 -7.52 -0.38 5.23e-13 Red blood cell count; LUSC cis rs4566357 0.539 rs10933164 chr2:227860671 A/G cg11843606 chr2:227700838 RHBDD1 -0.71 -9.72 -0.47 7.63e-20 Coronary artery disease; LUSC trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg03929089 chr4:120376271 NA 0.71 7.93 0.4 3.34e-14 Axial length; LUSC cis rs7772486 0.875 rs6909827 chr6:146365738 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.15 -0.36 5.34e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg00080972 chr5:178986291 RUFY1 -0.61 -10.85 -0.51 1.05e-23 Lung cancer; LUSC cis rs1865760 0.566 rs9467663 chr6:26021456 C/G cg17691542 chr6:26056736 HIST1H1C 0.47 7.03 0.36 1.19e-11 Height; LUSC cis rs8018808 0.935 rs7146595 chr14:77932017 A/C cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg00129232 chr17:37814104 STARD3 0.49 7.46 0.38 7.64e-13 Asthma; LUSC cis rs2041895 0.509 rs10861676 chr12:107311235 G/A cg13944111 chr12:107296891 NA 0.38 6.7 0.34 8.87e-11 Glaucoma (low intraocular pressure); LUSC cis rs965513 1.000 rs7027030 chr9:100550455 A/C cg13688889 chr9:100608707 NA -0.54 -8.05 -0.4 1.51e-14 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg02153584 chr22:29168773 CCDC117 0.58 8.65 0.43 2.26e-16 Lymphocyte counts; LUSC cis rs6834538 0.597 rs1486865 chr4:113465651 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.36 5.82 0.3 1.37e-8 Free thyroxine concentration; LUSC cis rs977987 0.806 rs11149833 chr16:75464002 G/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.42e-11 Dupuytren's disease; LUSC cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg01689657 chr7:91764605 CYP51A1 0.32 5.68 0.3 2.88e-8 Breast cancer; LUSC cis rs826838 0.559 rs4882276 chr12:38611994 T/C cg13010199 chr12:38710504 ALG10B 0.48 7.28 0.37 2.47e-12 Heart rate; LUSC cis rs9796 0.621 rs9972349 chr15:41491656 A/G cg18705301 chr15:41695430 NDUFAF1 -0.51 -9.0 -0.44 1.78e-17 Menopause (age at onset); LUSC cis rs7927592 0.789 rs2291467 chr11:68216756 C/T cg20283391 chr11:68216788 NA -0.65 -8.75 -0.43 1.04e-16 Total body bone mineral density; LUSC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg20476274 chr7:133979776 SLC35B4 0.88 16.76 0.68 3.47e-46 Mean platelet volume; LUSC cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg02527881 chr3:46936655 PTH1R 0.39 6.87 0.35 3.23e-11 Colorectal cancer; LUSC cis rs6722750 0.933 rs4671553 chr2:64408476 A/T cg22352474 chr2:64371530 PELI1 -0.53 -7.8 -0.39 7.95e-14 Neuroticism; LUSC cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg23711669 chr6:146136114 FBXO30 -0.83 -14.85 -0.63 1.13e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg02428538 chr16:24856791 SLC5A11 -0.5 -5.79 -0.3 1.64e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg27588902 chr6:42928151 GNMT -0.3 -6.67 -0.34 1.05e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg18132916 chr6:79620363 NA -0.38 -5.76 -0.3 1.9e-8 Intelligence (multi-trait analysis); LUSC cis rs12210905 0.688 rs12202956 chr6:27356476 T/C cg08851530 chr6:28072375 NA 0.93 6.11 0.32 2.71e-9 Hip circumference adjusted for BMI; LUSC cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg26384229 chr12:38710491 ALG10B 0.63 9.9 0.48 2.05e-20 Morning vs. evening chronotype; LUSC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg02569458 chr12:86230093 RASSF9 0.58 9.93 0.48 1.6e-20 Major depressive disorder; LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg22963979 chr7:1858916 MAD1L1 -0.58 -9.03 -0.44 1.43e-17 Bipolar disorder and schizophrenia; LUSC trans rs2854160 0.581 rs2727319 chr17:61960215 C/T cg09060275 chr22:27053596 MIAT -0.4 -5.99 -0.31 5.46e-9 Height; LUSC cis rs11122272 0.525 rs2749713 chr1:231537921 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.19 -0.49 2.13e-21 Hemoglobin concentration; LUSC cis rs3125734 0.633 rs4979774 chr10:63967795 A/T cg19640130 chr10:64028056 RTKN2 -0.41 -7.4 -0.38 1.08e-12 Rheumatoid arthritis; LUSC cis rs2439831 0.681 rs28594657 chr15:43588888 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.94 9.96 0.48 1.29e-20 Lung cancer in ever smokers; LUSC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg13683864 chr3:40499215 RPL14 -0.93 -15.98 -0.66 4.34e-43 Renal cell carcinoma; LUSC cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg03146154 chr1:46216737 IPP 0.54 7.93 0.4 3.32e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7208859 0.623 rs56018041 chr17:29059985 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2562456 0.917 rs2562468 chr19:21714850 G/A cg00806126 chr19:22604979 ZNF98 0.37 5.71 0.3 2.43e-8 Pain; LUSC cis rs12464483 0.591 rs4952171 chr2:30886903 G/A cg07150166 chr2:30669952 LCLAT1 0.65 7.03 0.36 1.17e-11 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg24642844 chr7:1081250 C7orf50 -0.8 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.24 -0.37 3.09e-12 Alzheimer's disease (late onset); LUSC cis rs67311347 0.713 rs114569261 chr3:40314580 G/A cg13683864 chr3:40499215 RPL14 -0.92 -15.88 -0.66 1.03e-42 Renal cell carcinoma; LUSC cis rs17102423 0.623 rs12100752 chr14:65611546 G/C cg11161011 chr14:65562177 MAX -0.63 -8.8 -0.43 7.71e-17 Obesity-related traits; LUSC cis rs929354 0.772 rs2301914 chr7:157000176 T/C cg17757837 chr7:157058334 UBE3C 0.83 13.32 0.59 9.37e-33 Body mass index; LUSC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg09580153 chr6:41068724 NFYA;LOC221442 0.55 8.01 0.4 1.92e-14 Alzheimer's disease (late onset); LUSC cis rs9378688 1.000 rs9392374 chr6:2223002 T/G cg12303981 chr6:2244766 GMDS -0.48 -5.68 -0.3 2.96e-8 Caudate nucleus volume; LUSC cis rs6964587 0.626 rs2269810 chr7:91508837 T/C cg17063962 chr7:91808500 NA -0.54 -8.81 -0.43 6.73e-17 Breast cancer; LUSC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg24838063 chr12:130822603 PIWIL1 0.69 10.79 0.51 1.69e-23 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00029397 chr12:57940957 DCTN2 0.42 6.01 0.31 4.79e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs668210 0.643 rs549334 chr11:65774659 C/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.59 7.87 0.4 4.86e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs9549367 0.713 rs3024761 chr13:113824090 C/G cg18105134 chr13:113819100 PROZ 0.8 11.33 0.53 2.2e-25 Platelet distribution width; LUSC trans rs12210905 0.925 rs72838243 chr6:26984198 A/T cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs1044573 0.514 rs2268879 chr20:25177805 C/T cg13962466 chr20:25176127 ENTPD6 -0.38 -6.18 -0.32 1.9e-9 Allergic rhinitis; LUSC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10484885 0.878 rs72921955 chr6:90588789 C/G cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.35 -0.42 1.88e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs208520 0.526 rs9351542 chr6:66788571 A/G cg07460842 chr6:66804631 NA -1.26 -27.65 -0.83 2.31e-88 Exhaled nitric oxide output; LUSC cis rs67981189 0.593 rs8006046 chr14:71498991 A/G cg15816911 chr14:71606274 NA 0.33 5.86 0.31 1.12e-8 Schizophrenia; LUSC cis rs11711311 1.000 rs9288984 chr3:113525956 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.94 0.36 2.04e-11 IgG glycosylation; LUSC trans rs17266958 1.000 rs62577010 chr9:83304978 T/G cg01905489 chr1:26616534 UBXN11 -0.58 -6.38 -0.33 6.04e-10 Preschool internalizing problems; LUSC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg00933542 chr6:150070202 PCMT1 0.3 5.82 0.3 1.41e-8 Lung cancer; LUSC cis rs6674970 1.000 rs61819219 chr1:151084375 C/G cg03258749 chr1:151040405 MLLT11 -0.43 -6.59 -0.34 1.76e-10 Childhood ear infection; LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg16405210 chr4:1374714 KIAA1530 -0.85 -13.93 -0.61 4.38e-35 Longevity; LUSC cis rs6908843 0.582 rs60948137 chr6:166666777 G/A cg06878426 chr6:166666287 NA 0.46 6.69 0.34 9.57e-11 Macrophage inflammatory protein 1b levels; LUSC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg03709012 chr19:19516395 GATAD2A 0.84 14.44 0.62 4.48e-37 Tonsillectomy; LUSC trans rs8072100 0.905 rs8077106 chr17:45653291 T/G cg04995722 chr7:26192034 NFE2L3 0.36 6.01 0.31 4.92e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg26769984 chr7:1090371 C7orf50 0.53 7.19 0.37 4.26e-12 Bronchopulmonary dysplasia; LUSC cis rs1355223 0.525 rs7129533 chr11:34872292 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.74 -0.35 7e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6469656 0.892 rs6469657 chr8:117668389 G/A cg24004040 chr8:117650383 NA -0.42 -6.26 -0.32 1.16e-9 Colorectal cancer; LUSC cis rs10203711 1.000 rs907113 chr2:239567724 T/C cg14580085 chr2:239553406 NA 0.42 7.1 0.36 7.48e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg22963979 chr7:1858916 MAD1L1 -0.64 -10.45 -0.5 2.56e-22 Bipolar disorder and schizophrenia; LUSC cis rs782590 0.522 rs12329050 chr2:55894428 G/A cg03859395 chr2:55845619 SMEK2 -0.68 -10.4 -0.49 3.9e-22 Metabolic syndrome; LUSC cis rs4363385 0.818 rs10788856 chr1:153011517 G/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs7809950 0.817 rs2701679 chr7:107283908 A/G cg23024343 chr7:107201750 COG5 0.55 8.2 0.41 5.4e-15 Coronary artery disease; LUSC cis rs68170813 0.652 rs77056542 chr7:107089751 G/C cg02696742 chr7:106810147 HBP1 -0.66 -8.43 -0.42 1.06e-15 Coronary artery disease; LUSC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.74 0.3 2.14e-8 Menopause (age at onset); LUSC cis rs3750082 0.754 rs35110377 chr7:32971770 C/G cg08946731 chr7:32981826 RP9P -0.36 -5.73 -0.3 2.29e-8 Glomerular filtration rate (creatinine); LUSC cis rs7100689 0.646 rs10736346 chr10:82134281 A/C cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs2073300 0.609 rs6132609 chr20:23400412 A/C cg12062639 chr20:23401060 NAPB 0.97 8.33 0.41 2.08e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs954108 0.809 rs715705 chr13:29369467 T/C cg11788234 chr13:29393811 NA -0.39 -6.7 -0.34 8.88e-11 Obesity-related traits; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg06873352 chr17:61820015 STRADA 0.7 12.6 0.57 4.58e-30 Prudent dietary pattern; LUSC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg00784671 chr22:46762841 CELSR1 -0.49 -6.06 -0.31 3.75e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg16031515 chr1:205743344 RAB7L1 -0.28 -6.11 -0.32 2.81e-9 Menarche (age at onset); LUSC cis rs9914988 0.943 rs9891925 chr17:27104540 A/T cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs500891 0.525 rs1145899 chr6:84039558 G/C cg08257003 chr6:84140564 ME1 0.32 7.12 0.36 6.58e-12 Platelet-derived growth factor BB levels; LUSC cis rs6681460 0.933 rs7554101 chr1:67156472 A/G cg02459107 chr1:67143332 SGIP1 -0.45 -8.36 -0.42 1.76e-15 Presence of antiphospholipid antibodies; LUSC cis rs9467773 0.620 rs2451732 chr6:26622904 A/T cg09904177 chr6:26538194 HMGN4 -0.66 -11.71 -0.54 8.71e-27 Intelligence (multi-trait analysis); LUSC cis rs9443189 0.570 rs569731 chr6:76357593 G/A cg01950844 chr6:76311363 SENP6 0.68 6.8 0.35 4.89e-11 Prostate cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04523929 chr3:10168401 C3orf10 -0.41 -6.61 -0.34 1.54e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 -0.71 -8.69 -0.43 1.71e-16 Lung function (FEV1/FVC); LUSC cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg13395646 chr4:1353034 KIAA1530 -0.6 -9.39 -0.46 9.79e-19 Longevity; LUSC cis rs7674212 0.531 rs4698876 chr4:103933567 T/G cg16532752 chr4:104119610 CENPE -0.42 -5.78 -0.3 1.69e-8 Type 2 diabetes; LUSC cis rs611744 0.647 rs11785776 chr8:109264933 C/T cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.17e-10 Dupuytren's disease; LUSC cis rs7809950 0.678 rs982447 chr7:106973534 T/C cg23024343 chr7:107201750 COG5 -0.66 -9.86 -0.47 2.6e-20 Coronary artery disease; LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg16325326 chr1:53192061 ZYG11B -0.9 -16.76 -0.68 3.56e-46 Monocyte count; LUSC cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.11 0.41 9.42e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2637266 1.000 rs12251568 chr10:78345667 C/T cg18941641 chr10:78392320 NA 0.37 6.92 0.35 2.34e-11 Pulmonary function; LUSC cis rs9905704 0.681 rs8081247 chr17:56557837 G/A cg12560992 chr17:57184187 TRIM37 -0.51 -5.8 -0.3 1.57e-8 Testicular germ cell tumor; LUSC cis rs2832077 1.000 rs2832065 chr21:30135362 C/T cg08807101 chr21:30365312 RNF160 -0.52 -6.44 -0.33 4.06e-10 Cognitive test performance; LUSC cis rs7267979 0.934 rs2261115 chr20:25259807 G/A cg08601574 chr20:25228251 PYGB 0.46 7.03 0.36 1.2e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs12210905 0.925 rs72838245 chr6:26987316 A/C cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg02951883 chr7:2050386 MAD1L1 0.55 10.14 0.49 3.12e-21 Bipolar disorder and schizophrenia; LUSC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.92 -0.81 3.6e-78 Height; LUSC cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg08213375 chr14:104286397 PPP1R13B -0.52 -10.48 -0.5 2.13e-22 Schizophrenia; LUSC cis rs3862260 1.000 rs3862260 chr1:120160789 G/A cg11530693 chr1:120165357 ZNF697 0.51 7.92 0.4 3.49e-14 Systemic lupus erythematosus; LUSC cis rs9473147 0.503 rs2171086 chr6:47590104 C/T cg12968598 chr6:47444699 CD2AP 0.53 8.12 0.41 9.35e-15 Platelet distribution width;Mean platelet volume; LUSC cis rs9300255 0.620 rs1716173 chr12:123660721 A/T cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.51 -0.34 2.81e-10 Neutrophil percentage of white cells; LUSC cis rs4268898 0.552 rs12620938 chr2:24367122 C/A cg06627628 chr2:24431161 ITSN2 0.51 7.26 0.37 2.7e-12 Asthma; LUSC cis rs9326248 0.581 rs10790167 chr11:116800943 T/C cg10130564 chr11:117069849 TAGLN 0.3 5.65 0.3 3.37e-8 Blood protein levels; LUSC cis rs3771570 1.000 rs62193207 chr2:242318501 G/C cg21155796 chr2:242212141 HDLBP 0.62 6.67 0.34 1.07e-10 Prostate cancer; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.23 0.52 4.67e-25 Prudent dietary pattern; LUSC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.14 0.36 5.93e-12 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9388451 0.807 rs1268070 chr6:126041164 A/G cg10911889 chr6:126070802 HEY2 0.38 5.77 0.3 1.81e-8 Brugada syndrome; LUSC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg06640241 chr16:89574553 SPG7 0.86 16.11 0.66 1.33e-43 Multiple myeloma (IgH translocation); LUSC cis rs61931739 0.517 rs1197562 chr12:34122037 G/A cg06521331 chr12:34319734 NA -0.5 -8.24 -0.41 3.97e-15 Morning vs. evening chronotype; LUSC cis rs12579753 1.000 rs10862374 chr12:82250809 G/C cg07988820 chr12:82153109 PPFIA2 -0.42 -5.78 -0.3 1.69e-8 Resting heart rate; LUSC cis rs1472147 0.955 rs3736614 chr7:128509048 T/G cg00260937 chr7:128520193 KCP 0.43 5.8 0.3 1.55e-8 Calcium levels; LUSC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg08219700 chr8:58056026 NA 0.5 6.57 0.34 1.98e-10 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.21 29.22 0.85 5e-94 Chronic sinus infection; LUSC cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.43 -0.59 3.51e-33 Chronic sinus infection; LUSC cis rs7937682 0.564 rs1944114 chr11:111366460 T/C cg09085632 chr11:111637200 PPP2R1B 0.44 5.84 0.3 1.24e-8 Primary sclerosing cholangitis; LUSC cis rs10779751 0.734 rs2791653 chr1:11129848 A/G cg08854313 chr1:11322531 MTOR 0.84 12.9 0.58 3.7e-31 Body mass index; LUSC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg08677398 chr8:58056175 NA 0.51 6.53 0.34 2.38e-10 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.616 rs28417656 chr11:50040152 C/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs997295 0.675 rs17242605 chr15:67963436 A/G cg08079166 chr15:68083412 MAP2K5 -0.33 -6.56 -0.34 2.11e-10 Motion sickness; LUSC trans rs9329221 0.537 rs2062331 chr8:9979992 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.41 -0.38 1.01e-12 Neuroticism; LUSC trans rs2243480 1.000 rs313803 chr7:65514731 G/A cg10756647 chr7:56101905 PSPH 0.85 8.22 0.41 4.44e-15 Diabetic kidney disease; LUSC cis rs11997175 0.509 rs67427312 chr8:33674377 A/G ch.8.33884649F chr8:33765107 NA 0.44 6.31 0.33 8.73e-10 Body mass index; LUSC cis rs1044826 0.642 rs9859864 chr3:139091219 G/T cg15131784 chr3:139108705 COPB2 -0.42 -6.97 -0.36 1.74e-11 Obesity-related traits; LUSC cis rs231513 0.813 rs231495 chr17:41976748 G/C cg26893861 chr17:41843967 DUSP3 -0.51 -6.06 -0.31 3.74e-9 Cognitive function; LUSC cis rs17286411 0.814 rs12708919 chr16:71986995 A/G cg03805757 chr16:71968109 PKD1L3 -0.4 -6.75 -0.35 6.62e-11 Blood protein levels; LUSC cis rs56399783 0.901 rs11971014 chr7:2778444 C/T cg19731401 chr7:2775893 GNA12 0.67 8.33 0.41 2.07e-15 Childhood ear infection; LUSC cis rs763121 0.744 rs5757140 chr22:38957013 T/C cg06022373 chr22:39101656 GTPBP1 0.77 11.77 0.54 5.6e-27 Menopause (age at onset); LUSC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg12454169 chr2:30669597 LCLAT1 0.7 8.71 0.43 1.43e-16 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg27494647 chr7:150038898 RARRES2 0.46 6.98 0.36 1.61e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs9486719 1.000 rs2092096 chr6:96870919 A/G cg06623918 chr6:96969491 KIAA0776 0.77 9.7 0.47 9.04e-20 Migraine;Coronary artery disease; LUSC cis rs929354 0.739 rs1182439 chr7:157027367 G/A cg17757837 chr7:157058334 UBE3C -0.82 -13.32 -0.59 9.02e-33 Body mass index; LUSC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg06238570 chr21:40685208 BRWD1 0.49 7.5 0.38 5.77e-13 Cognitive function; LUSC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.37 0.46 1.14e-18 Bipolar disorder; LUSC trans rs16944687 0.536 rs4843349 chr16:86131064 A/G cg17191256 chr10:131665419 EBF3 -0.53 -6.02 -0.31 4.54e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg26897989 chr16:1907736 C16orf73 -0.42 -6.63 -0.34 1.37e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg16049864 chr8:95962084 TP53INP1 0.61 10.85 0.51 1.06e-23 Type 2 diabetes; LUSC cis rs9649213 0.586 rs55648546 chr7:97960800 G/A cg08684580 chr7:98029266 BAIAP2L1 0.39 5.88 0.31 9.82e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6906287 0.647 rs13220480 chr6:118916627 G/A cg21191810 chr6:118973309 C6orf204 0.32 5.92 0.31 7.82e-9 Electrocardiographic conduction measures; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg22764044 chr5:178986830 RUFY1 0.53 8.99 0.44 1.81e-17 Lung cancer; LUSC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg07701084 chr6:150067640 NUP43 0.57 8.95 0.44 2.49e-17 Lung cancer; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.33 -0.41 2.09e-15 Lymphocyte counts; LUSC cis rs394563 0.781 rs61516098 chr6:149794289 A/T cg07828024 chr6:149772892 ZC3H12D -0.32 -6.92 -0.35 2.3e-11 Dupuytren's disease; LUSC cis rs2522056 1.000 rs62385693 chr5:131773674 T/C cg24060327 chr5:131705240 SLC22A5 0.49 6.82 0.35 4.19e-11 Lymphocyte counts;Fibrinogen; LUSC trans rs12310956 0.532 rs1589902 chr12:33989289 G/A cg13010199 chr12:38710504 ALG10B 0.52 7.72 0.39 1.34e-13 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg01017244 chr2:74357527 NA 0.7 13.46 0.59 2.74e-33 Gestational age at birth (maternal effect); LUSC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 12.01 0.55 7.58e-28 Personality dimensions; LUSC cis rs7561273 0.609 rs10200844 chr2:24293363 A/C cg20701182 chr2:24300061 SF3B14 0.45 5.77 0.3 1.76e-8 Quantitative traits; LUSC trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7193541 0.564 rs4888274 chr16:74706298 A/T cg01733217 chr16:74700730 RFWD3 1.0 22.46 0.78 1.02e-68 Multiple myeloma; LUSC cis rs59104589 0.617 rs57696929 chr2:242380382 T/C cg14842376 chr2:242211374 HDLBP 0.5 5.78 0.3 1.73e-8 Fibrinogen levels; LUSC cis rs886126 1.000 rs3809286 chr12:111664404 C/T cg10833066 chr12:111807467 FAM109A 0.42 6.6 0.34 1.59e-10 Coronary heart disease; LUSC cis rs67478160 0.584 rs12433009 chr14:104196405 C/G cg01849466 chr14:104193079 ZFYVE21 -0.65 -11.12 -0.52 1.19e-24 Schizophrenia; LUSC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg11366901 chr6:160182831 ACAT2 0.93 12.7 0.57 2.1000000000000002e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.31 -0.33 8.87e-10 Personality dimensions; LUSC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg16434002 chr17:42200994 HDAC5 -0.44 -6.3 -0.33 9.53e-10 Total body bone mineral density; LUSC cis rs1577917 1.000 rs1577919 chr6:86757296 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.46 -0.42 8.72e-16 Response to antipsychotic treatment; LUSC cis rs7618501 1.000 rs6446295 chr3:49809063 G/T cg13072238 chr3:49761600 GMPPB 0.4 6.6 0.34 1.62e-10 Intelligence (multi-trait analysis); LUSC cis rs4629180 0.586 rs290773 chr2:102125930 G/A cg04415270 chr2:102091202 RFX8 0.46 8.03 0.4 1.71e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs921968 0.565 rs1529382 chr2:219626489 C/T cg02176678 chr2:219576539 TTLL4 -0.58 -10.36 -0.49 5.62e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg15242686 chr22:24348715 GSTTP1 -0.39 -6.38 -0.33 5.91e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs259282 0.707 rs1103851 chr19:33146414 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.82 12.23 0.56 1.09e-28 Schizophrenia; LUSC cis rs524023 0.915 rs531763 chr11:64352063 A/G cg19131476 chr11:64387923 NRXN2 0.37 9.89 0.48 2.14e-20 Urate levels in obese individuals; LUSC cis rs4268898 0.760 rs11125535 chr2:24528114 T/C cg06627628 chr2:24431161 ITSN2 0.58 8.23 0.41 4.39e-15 Asthma; LUSC cis rs6541297 0.941 rs2144299 chr1:230280366 A/G cg05784532 chr1:230284198 GALNT2 0.65 9.02 0.44 1.45e-17 Coronary artery disease; LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4076764 0.535 rs4409627 chr1:163382050 A/G cg06092702 chr1:163392909 NA 0.35 6.18 0.32 1.9e-9 Motion sickness; LUSC cis rs4589502 0.920 rs77518050 chr15:67138089 T/C cg12317470 chr15:67143691 NA 0.7 6.02 0.31 4.7e-9 Lung cancer (smoking interaction); LUSC cis rs13064411 0.696 rs7613546 chr3:113228019 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -7.69 -0.39 1.66e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.76 8.6 0.43 3.15e-16 Diabetic retinopathy; LUSC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg04398451 chr17:18023971 MYO15A -0.56 -9.15 -0.45 5.87e-18 Total body bone mineral density; LUSC cis rs7191439 0.858 rs6500489 chr16:88772046 T/C cg02389323 chr16:88786976 FAM38A 1.22 10.31 0.49 8.08e-22 Plateletcrit; LUSC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg24250549 chr1:154909240 PMVK 0.62 10.16 0.49 2.61e-21 Prostate cancer; LUSC trans rs561341 0.882 rs16967101 chr17:30377162 A/G cg27661571 chr11:113659931 NA -0.64 -7.52 -0.38 5e-13 Hip circumference adjusted for BMI; LUSC trans rs35110281 0.667 rs7282122 chr21:45082365 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 9.98 0.48 1.04e-20 Mean corpuscular volume; LUSC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg06108461 chr20:60628389 TAF4 -0.65 -8.47 -0.42 8.04e-16 Obesity-related traits; LUSC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg26380479 chr7:97908229 NA -0.26 -5.87 -0.31 1.06e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg02772935 chr3:125709198 NA -0.48 -5.82 -0.3 1.36e-8 Blood pressure (smoking interaction); LUSC cis rs1595825 1.000 rs7579905 chr2:198868109 T/A cg00982548 chr2:198649783 BOLL -0.5 -6.26 -0.32 1.21e-9 Ulcerative colitis; LUSC cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -8.1 -0.41 1.06e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.53e-30 Motion sickness; LUSC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg21862992 chr11:68658383 NA 0.51 8.4 0.42 1.32e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12579753 1.000 rs7300900 chr12:82166821 G/T cg21231944 chr12:82153410 PPFIA2 -0.39 -6.0 -0.31 5.16e-9 Resting heart rate; LUSC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9644630 0.932 rs4922048 chr8:19360814 A/G cg01280390 chr8:19363452 CSGALNACT1 0.35 6.7 0.34 8.83e-11 Oropharynx cancer; LUSC cis rs9868809 0.772 rs12107418 chr3:48689787 A/G cg00383909 chr3:49044727 WDR6 0.81 7.55 0.38 4.26e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg05347473 chr6:146136440 FBXO30 -0.57 -9.79 -0.47 4.48e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs34779708 0.966 rs10827493 chr10:35454976 C/T cg03585969 chr10:35415529 CREM 0.62 9.23 0.45 3.2e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.05e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs12421382 0.636 rs1371329 chr11:109382725 G/T cg16359550 chr11:109292809 C11orf87 -0.38 -6.59 -0.34 1.76e-10 Schizophrenia; LUSC cis rs6733011 0.578 rs10169003 chr2:99508866 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.47 6.6 0.34 1.58e-10 Bipolar disorder; LUSC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 10.14 0.49 3.03e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10779751 1.000 rs718206 chr1:11294474 T/A cg08854313 chr1:11322531 MTOR 0.87 15.04 0.64 2.13e-39 Body mass index; LUSC cis rs9814567 1.000 rs7611611 chr3:134307877 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 14.57 0.62 1.47e-37 Platelet count; LUSC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg21963583 chr11:68658836 MRPL21 0.55 8.17 0.41 6.57e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs3749237 1.000 rs11710675 chr3:49751900 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.51 7.23 0.37 3.36e-12 Resting heart rate; LUSC cis rs9325144 0.723 rs1586373 chr12:39181582 G/A cg13010199 chr12:38710504 ALG10B -0.5 -7.59 -0.38 3.32e-13 Morning vs. evening chronotype; LUSC trans rs9467711 0.790 rs67777156 chr6:26633711 T/A cg06606381 chr12:133084897 FBRSL1 -0.9 -7.7 -0.39 1.51e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs317689 0.819 rs317660 chr12:69686203 G/A cg11871910 chr12:69753446 YEATS4 0.46 6.14 0.32 2.3e-9 Response to diuretic therapy; LUSC cis rs7917772 0.604 rs10883756 chr10:104400112 T/C cg22532475 chr10:104410764 TRIM8 0.32 7.23 0.37 3.33e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.48 -0.42 7.3e-16 Obesity-related traits; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg02018176 chr4:1364513 KIAA1530 0.52 8.86 0.44 5e-17 Obesity-related traits; LUSC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg12751644 chr20:60527061 NA -0.35 -6.43 -0.33 4.43e-10 Body mass index; LUSC cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg03146154 chr1:46216737 IPP 0.49 7.35 0.37 1.49e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13217239 0.608 rs6930508 chr6:27053142 T/C cg09904177 chr6:26538194 HMGN4 -0.51 -8.08 -0.4 1.17e-14 Schizophrenia; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg07677032 chr17:61819896 STRADA 0.52 8.7 0.43 1.53e-16 Prudent dietary pattern; LUSC cis rs10089 1.000 rs3805606 chr5:127470813 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.88 -12.24 -0.56 1.05e-28 Ileal carcinoids; LUSC cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg27279351 chr12:120934652 DYNLL1 0.62 8.23 0.41 4.34e-15 High light scatter reticulocyte count; LUSC cis rs782590 0.934 rs17369191 chr2:55757885 T/C cg03859395 chr2:55845619 SMEK2 0.87 16.39 0.67 1.02e-44 Metabolic syndrome; LUSC cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg06784218 chr1:46089804 CCDC17 0.45 8.37 0.42 1.62e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg16339924 chr4:17578868 LAP3 0.59 9.18 0.45 4.48e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg08847533 chr14:75593920 NEK9 0.85 15.93 0.66 6.91e-43 Height; LUSC trans rs4332037 0.950 rs7807014 chr7:1939021 T/C cg10840412 chr1:235813424 GNG4 0.66 8.83 0.44 6.18e-17 Bipolar disorder; LUSC cis rs6121246 0.512 rs6058384 chr20:30276409 A/T cg13852791 chr20:30311386 BCL2L1 0.95 14.8 0.63 1.85e-38 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs2836633 0.929 rs11701577 chr21:40028906 C/T cg05519781 chr21:40033154 ERG 0.77 13.34 0.59 7.52e-33 Coronary artery disease; LUSC cis rs7584330 0.666 rs937386 chr2:238364039 C/T cg16989719 chr2:238392110 NA -0.46 -7.39 -0.37 1.21e-12 Prostate cancer; LUSC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs208520 0.690 rs851458 chr6:66813279 T/G cg07460842 chr6:66804631 NA -1.14 -18.11 -0.7 1.5e-51 Exhaled nitric oxide output; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg01802117 chr1:53393560 SCP2 -0.38 -6.41 -0.33 5.02e-10 Monocyte count; LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.96 0.77 8.49e-67 Prudent dietary pattern; LUSC cis rs11992186 0.597 rs77717027 chr8:8591632 T/C cg15556689 chr8:8085844 FLJ10661 -0.43 -5.97 -0.31 6.04e-9 Neuroticism; LUSC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg14004847 chr7:1930337 MAD1L1 0.55 8.52 0.42 5.39e-16 Bipolar disorder and schizophrenia; LUSC cis rs11792861 0.589 rs2176692 chr9:111927723 G/A cg05043794 chr9:111880884 C9orf5 -0.34 -7.15 -0.36 5.56e-12 Menarche (age at onset); LUSC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg23172400 chr8:95962367 TP53INP1 0.36 6.67 0.34 1.03e-10 Type 2 diabetes; LUSC trans rs72674100 1.000 rs7672661 chr4:97954691 C/A cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9341808 0.527 rs7453746 chr6:80810013 T/G cg08355045 chr6:80787529 NA 0.62 11.55 0.53 3.41e-26 Sitting height ratio; LUSC cis rs7312933 0.510 rs61942483 chr12:42499538 T/A cg01256987 chr12:42539512 GXYLT1 -0.61 -13.42 -0.59 3.98e-33 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg20476274 chr7:133979776 SLC35B4 0.87 16.61 0.67 1.39e-45 Mean platelet volume; LUSC cis rs9394152 0.845 rs9366823 chr6:33471059 C/T cg13560919 chr6:33536144 NA 0.6 10.63 0.5 6.18e-23 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs10392 0.543 rs1733 chr20:37581506 G/A cg27552599 chr20:37590471 DHX35 0.43 7.03 0.36 1.19e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs72634258 0.945 rs225131 chr1:8095486 T/C cg26816564 chr1:7831052 VAMP3 0.47 6.18 0.32 1.89e-9 Inflammatory bowel disease; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg02599293 chr5:137090023 HNRNPA0 0.38 6.45 0.33 3.91e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg26384229 chr12:38710491 ALG10B 0.87 14.22 0.61 3.36e-36 Bladder cancer; LUSC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg22823121 chr1:150693482 HORMAD1 0.52 7.84 0.39 6.31e-14 Melanoma; LUSC cis rs909341 0.909 rs67616625 chr20:62363487 A/G cg09650180 chr20:62225654 GMEB2 -0.47 -6.11 -0.32 2.75e-9 Atopic dermatitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21144462 chr17:42082647 PYY;NAGS 0.38 5.99 0.31 5.54e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs34779708 0.931 rs12240347 chr10:35359475 A/G cg03585969 chr10:35415529 CREM 0.6 8.8 0.43 7.41e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs7267979 1.000 rs6037095 chr20:25335687 A/G cg08601574 chr20:25228251 PYGB -0.44 -6.8 -0.35 4.71e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs62458065 0.513 rs9655340 chr7:32535920 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.55 6.04 0.31 4.07e-9 Metabolite levels (HVA/MHPG ratio); LUSC trans rs2587949 0.615 rs1485248 chr3:4238123 G/A cg15139668 chr4:4577005 NA -0.4 -5.98 -0.31 5.86e-9 Periodontitis (DPAL); LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg07677032 chr17:61819896 STRADA 0.52 8.61 0.43 2.91e-16 Prudent dietary pattern; LUSC cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -7.74 -0.39 1.22e-13 Glomerular filtration rate (creatinine); LUSC cis rs9650657 0.506 rs7823296 chr8:10778546 A/G cg27411982 chr8:10470053 RP1L1 -0.48 -7.21 -0.37 3.65e-12 Neuroticism; LUSC cis rs1003719 0.715 rs2156078 chr21:38546473 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg07741184 chr6:167504864 NA -0.35 -6.39 -0.33 5.46e-10 Crohn's disease; LUSC cis rs3741151 0.773 rs7951072 chr11:73221721 G/A cg17517138 chr11:73019481 ARHGEF17 0.96 8.13 0.41 8.27e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs629535 0.814 rs55873935 chr8:70081646 G/A cg21567404 chr3:27674614 NA -0.97 -15.65 -0.65 8.2e-42 Dupuytren's disease; LUSC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg11812906 chr14:75593930 NEK9 -0.65 -11.23 -0.52 4.73e-25 Height; LUSC cis rs11608355 0.515 rs4766476 chr12:109934700 A/G cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs9807841 0.568 rs1560708 chr19:10749236 T/C cg09936142 chr19:10668400 KRI1 -0.4 -6.34 -0.33 7.33e-10 Inflammatory skin disease; LUSC cis rs9463078 0.625 rs12190136 chr6:44767072 A/G cg25276700 chr6:44698697 NA -0.28 -5.7 -0.3 2.64e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg20849893 chr7:64541193 NA -0.65 -5.68 -0.3 2.99e-8 Diabetic kidney disease; LUSC cis rs9527 0.590 rs10786744 chr10:104945028 A/C cg23093090 chr10:104574429 C10orf26 0.35 6.45 0.33 3.91e-10 Arsenic metabolism; LUSC cis rs559928 0.606 rs11605856 chr11:63925528 C/T cg05555928 chr11:63887634 MACROD1 -0.52 -6.35 -0.33 7.06e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs394563 0.625 rs394526 chr6:149796975 T/G cg11245181 chr6:149772854 ZC3H12D -0.3 -5.98 -0.31 5.73e-9 Dupuytren's disease; LUSC cis rs3936840 0.686 rs2896439 chr14:102806291 A/G cg18135206 chr14:102964638 TECPR2 0.49 7.28 0.37 2.44e-12 Plateletcrit; LUSC cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg08999081 chr20:33150536 PIGU -0.52 -10.34 -0.49 6.18e-22 Glomerular filtration rate (creatinine); LUSC cis rs7824557 0.836 rs2736378 chr8:11119760 G/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.98 -0.31 5.62e-9 Retinal vascular caliber; LUSC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.81 -0.35 4.59e-11 Lung cancer; LUSC cis rs12997796 0.556 rs35594332 chr2:86982651 G/A cg25203885 chr2:87302643 LOC285074 -0.86 -8.64 -0.43 2.35e-16 Schizophrenia; LUSC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg00343986 chr7:65444356 GUSB 0.44 6.79 0.35 5.23e-11 Aortic root size; LUSC cis rs2463822 0.614 rs117699706 chr11:62161659 T/C cg06239285 chr11:62104954 ASRGL1 -0.96 -10.27 -0.49 1.13e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7582180 0.652 rs11694700 chr2:100936637 C/T cg12002119 chr2:101014098 CHST10 0.34 5.7 0.3 2.62e-8 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs377070 0.934 rs309414 chr4:123620912 A/C cg10495464 chr4:123653540 BBS12;LOC729338 0.46 6.73 0.35 7.46e-11 Mosquito bite size; LUSC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.23 -0.32 1.37e-9 Lung cancer; LUSC cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg01528321 chr10:82214614 TSPAN14 0.63 9.08 0.44 9.59e-18 Post bronchodilator FEV1; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg09177884 chr7:1199841 ZFAND2A -0.6 -8.35 -0.42 1.9e-15 Longevity;Endometriosis; LUSC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.75 0.43 1.05e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs9309711 0.772 rs9309715 chr2:3492318 C/G cg10845886 chr2:3471009 TTC15 0.52 6.65 0.34 1.21e-10 Neurofibrillary tangles; LUSC cis rs62458065 0.850 rs10239812 chr7:32460348 A/G cg20159608 chr7:32802032 NA -0.68 -7.86 -0.4 5.33e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs10779751 0.734 rs2791647 chr1:11132801 G/A cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs478304 0.651 rs4014192 chr11:65498915 C/T cg05805236 chr11:65401703 PCNXL3 -0.57 -9.25 -0.45 2.79e-18 Acne (severe); LUSC cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.5 0.42 6.57e-16 Colorectal cancer; LUSC trans rs7819412 0.811 rs2409691 chr8:10943276 C/T cg15556689 chr8:8085844 FLJ10661 -0.47 -7.02 -0.36 1.27e-11 Triglycerides; LUSC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.39 5.75 0.3 2.01e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10983056 chr13:113344077 ATP11A -0.41 -6.04 -0.31 4.08e-9 Hepatitis; LUSC cis rs7215564 0.908 rs34914062 chr17:78655909 C/T cg23238734 chr17:78661607 RPTOR 0.5 6.1 0.32 2.95e-9 Myopia (pathological); LUSC cis rs908922 0.676 rs4240887 chr1:152530510 C/T cg20991723 chr1:152506922 NA -0.5 -9.39 -0.46 9.93e-19 Hair morphology; LUSC cis rs2000999 0.515 rs2854956 chr16:72115238 A/T cg23815491 chr16:72088622 HP 0.34 6.01 0.31 4.87e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; LUSC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg04673462 chr1:38461896 NA -0.55 -10.16 -0.49 2.61e-21 Coronary artery disease; LUSC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg00409905 chr10:38381863 ZNF37A 0.37 6.32 0.33 8.19e-10 Extrinsic epigenetic age acceleration; LUSC cis rs8017423 0.967 rs61231898 chr14:90691696 G/A cg04374321 chr14:90722782 PSMC1 0.71 11.29 0.53 2.87e-25 Mortality in heart failure; LUSC cis rs6542838 0.644 rs7590596 chr2:99467938 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.6 -0.34 1.64e-10 Fear of minor pain; LUSC cis rs6570726 0.935 rs388394 chr6:145852689 C/T cg05347473 chr6:146136440 FBXO30 0.44 7.45 0.38 8.04e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6547741 1.000 rs4666007 chr2:27856495 T/C cg27432699 chr2:27873401 GPN1 0.78 14.13 0.61 7.32e-36 Oral cavity cancer; LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.71 -0.34 8.3e-11 Bipolar disorder and schizophrenia; LUSC cis rs7786808 0.653 rs4909213 chr7:158202404 G/A cg09998033 chr7:158218633 PTPRN2 -0.5 -7.99 -0.4 2.24e-14 Obesity-related traits; LUSC cis rs7804356 1.000 rs3801827 chr7:26856626 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs10927875 0.562 rs10803401 chr1:16147377 G/A cg22431228 chr1:16359049 CLCNKA 0.34 6.41 0.33 5.1e-10 Dilated cardiomyopathy; LUSC cis rs10465746 0.747 rs10493741 chr1:84388118 G/C cg10977910 chr1:84465055 TTLL7 0.46 6.61 0.34 1.53e-10 Obesity-related traits; LUSC cis rs3106136 0.967 rs282449 chr4:95141228 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.12 -0.32 2.68e-9 Capecitabine sensitivity; LUSC cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg05347473 chr6:146136440 FBXO30 -0.6 -10.43 -0.5 3.17e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg16434002 chr17:42200994 HDAC5 -0.47 -6.9 -0.35 2.68e-11 Total body bone mineral density; LUSC cis rs17533156 0.954 rs73376341 chr17:75116150 C/T cg11416367 chr17:75137675 SEC14L1 0.49 5.84 0.3 1.21e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.3 0.33 9.41e-10 Lung cancer; LUSC cis rs2637266 0.756 rs846621 chr10:78545171 G/T cg18941641 chr10:78392320 NA 0.38 6.8 0.35 4.76e-11 Pulmonary function; LUSC trans rs853679 0.546 rs200949 chr6:27835435 A/G cg06606381 chr12:133084897 FBRSL1 -0.67 -6.85 -0.35 3.65e-11 Depression; LUSC cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg25427524 chr10:38739819 LOC399744 0.45 7.41 0.38 1.08e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1211375 0.628 rs3859141 chr16:245079 T/C cg00126636 chr16:237282 NA -0.38 -5.82 -0.3 1.35e-8 Hematology traits;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs55882075 0.634 rs12518476 chr5:179110850 A/G cg14593053 chr5:179126677 CANX 0.38 5.98 0.31 5.63e-9 Monocyte percentage of white cells; LUSC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg18305652 chr10:134549665 INPP5A 0.46 6.99 0.36 1.49e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg05425664 chr17:57184151 TRIM37 -0.52 -7.66 -0.39 2.1e-13 Intelligence (multi-trait analysis); LUSC trans rs7843479 1.000 rs7843479 chr8:21820813 G/T cg10573190 chr2:85843190 USP39 -0.43 -6.08 -0.32 3.3e-9 Mean corpuscular volume; LUSC cis rs501916 0.714 rs11854427 chr15:48047421 G/A cg16110827 chr15:48056943 SEMA6D -0.45 -6.24 -0.32 1.3e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg24642439 chr20:33292090 TP53INP2 0.47 7.0 0.36 1.38e-11 Glomerular filtration rate (creatinine); LUSC cis rs425277 1.000 rs262667 chr1:2082722 T/C cg03732007 chr1:2071316 PRKCZ 0.48 7.72 0.39 1.34e-13 Height; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.05 0.55 5e-28 Prudent dietary pattern; LUSC cis rs4285028 0.747 rs9850439 chr3:121393075 T/C cg11130432 chr3:121712080 ILDR1 -0.56 -8.13 -0.41 8.7e-15 Multiple sclerosis; LUSC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg04450456 chr4:17643702 FAM184B 0.4 6.77 0.35 5.72e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg25204440 chr1:209979598 IRF6 0.53 6.98 0.36 1.63e-11 Cleft lip with or without cleft palate; LUSC cis rs1322512 0.917 rs1407485 chr6:152963665 G/A cg27316956 chr6:152958899 SYNE1 -0.37 -6.32 -0.33 8.6e-10 Tonometry; LUSC cis rs9467773 1.000 rs6940053 chr6:26562122 C/T cg05738196 chr6:26577821 NA 0.83 16.17 0.66 7.5e-44 Intelligence (multi-trait analysis); LUSC cis rs10089 1.000 rs6595800 chr5:127411647 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.83 11.98 0.55 9.1e-28 Ileal carcinoids; LUSC cis rs2046867 0.628 rs1393584 chr3:72917193 G/T cg25664220 chr3:72788482 NA -0.56 -9.93 -0.48 1.53e-20 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7091068 0.522 rs11187621 chr10:95483074 T/C cg20715218 chr10:95462985 C10orf4 0.6 7.38 0.37 1.3e-12 Urinary tract infection frequency; LUSC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 9.97 0.48 1.17e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9517320 0.515 rs61969456 chr13:99174799 C/G cg20487152 chr13:99095054 FARP1 -0.41 -7.05 -0.36 1.01e-11 Longevity; LUSC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg19717773 chr7:2847554 GNA12 -0.35 -5.78 -0.3 1.7e-8 Height; LUSC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg26727032 chr16:67993705 SLC12A4 -0.46 -6.27 -0.32 1.11e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg05585544 chr11:47624801 NA 0.4 7.03 0.36 1.16e-11 Subjective well-being; LUSC cis rs4951018 0.821 rs7529037 chr1:205637501 C/G cg17178900 chr1:205818956 PM20D1 -0.4 -5.68 -0.3 2.96e-8 Prostate-specific antigen levels; LUSC cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4076764 0.846 rs10753616 chr1:163415855 G/T cg24596788 chr1:163392923 NA 0.37 6.37 0.33 6.21e-10 Motion sickness; LUSC cis rs921968 0.612 rs2384950 chr2:219499719 T/C cg02176678 chr2:219576539 TTLL4 0.6 11.12 0.52 1.23e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs2292864 0.764 rs3892085 chr17:45340480 A/G cg18085866 chr17:45331354 ITGB3 -0.71 -6.06 -0.31 3.65e-9 Left atrial antero-posterior diameter; LUSC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7582180 0.629 rs13004216 chr2:100945402 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg18404041 chr3:52824283 ITIH1 -0.57 -11.2 -0.52 5.98e-25 Bipolar disorder; LUSC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467711 0.790 rs35400317 chr6:26593275 C/T cg09904177 chr6:26538194 HMGN4 -0.79 -5.78 -0.3 1.73e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs7608623 0.804 rs3795938 chr2:23912712 C/T cg08917208 chr2:24149416 ATAD2B -0.42 -5.73 -0.3 2.19e-8 Obesity-related traits; LUSC cis rs8092503 0.904 rs12606230 chr18:52492252 T/C cg12377874 chr18:52495404 RAB27B 0.33 6.05 0.31 3.85e-9 Childhood body mass index; LUSC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg04944784 chr2:26401820 FAM59B -0.68 -9.57 -0.46 2.52e-19 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.76 -0.3 1.91e-8 Menopause (age at onset); LUSC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg02423579 chr7:2872169 GNA12 -0.4 -6.35 -0.33 7.18e-10 Height; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg19318889 chr4:1322082 MAEA 0.48 7.88 0.4 4.54e-14 Obesity-related traits; LUSC trans rs35110281 0.755 rs4819270 chr21:45020919 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.42 0.53 9.87e-26 Mean corpuscular volume; LUSC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.37 -0.33 6.25e-10 Lung cancer; LUSC cis rs9616064 0.531 rs9616086 chr22:47050744 G/A cg25730555 chr22:47059586 GRAMD4 0.45 7.07 0.36 9.04e-12 Urate levels in obese individuals; LUSC cis rs10189230 0.868 rs5002064 chr2:222353508 G/A cg14652038 chr2:222343519 EPHA4 0.32 5.73 0.3 2.29e-8 Urate levels in lean individuals; LUSC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg07936489 chr17:37558343 FBXL20 -0.71 -9.83 -0.47 3.52e-20 Glomerular filtration rate (creatinine); LUSC cis rs6502050 0.736 rs11658040 chr17:80059891 C/T cg13939156 chr17:80058883 NA 0.37 7.46 0.38 7.64e-13 Life satisfaction; LUSC cis rs11051970 0.679 rs2931554 chr12:32556162 G/A cg02745156 chr12:32552066 NA 0.37 6.81 0.35 4.42e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg00310523 chr12:86230176 RASSF9 0.44 7.92 0.4 3.51e-14 Major depressive disorder; LUSC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg15448220 chr1:150897856 SETDB1 0.42 6.07 0.32 3.43e-9 Melanoma; LUSC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg12379764 chr21:47803548 PCNT -0.41 -5.65 -0.3 3.42e-8 Testicular germ cell tumor; LUSC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs1178968 0.901 rs799306 chr7:72801939 C/T cg25889504 chr7:72793014 NA 0.66 8.29 0.41 2.73e-15 Triglyceride levels; LUSC cis rs5769707 0.749 rs8137251 chr22:50036669 G/A cg07959070 chr22:50026188 C22orf34 -0.33 -6.32 -0.33 8.55e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg06637938 chr14:75390232 RPS6KL1 0.52 8.21 0.41 4.86e-15 Height; LUSC cis rs11098499 0.691 rs9996644 chr4:120238877 G/T cg24375607 chr4:120327624 NA 0.75 11.83 0.54 3.24e-27 Corneal astigmatism; LUSC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg09517075 chr8:22133004 PIWIL2 -0.41 -8.45 -0.42 9e-16 Hypertriglyceridemia; LUSC cis rs5770917 1.000 rs115743514 chr22:51011933 T/C cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.68 -0.3 2.92e-8 Narcolepsy; LUSC cis rs644799 0.526 rs534973 chr11:95633624 A/T cg03916912 chr11:95522834 CEP57;FAM76B 0.6 9.56 0.46 2.66e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs9329221 0.736 rs11249999 chr8:10251265 C/T cg15556689 chr8:8085844 FLJ10661 -0.61 -8.61 -0.43 3e-16 Neuroticism; LUSC cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs2281558 0.833 rs6115202 chr20:25497538 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.62 -9.36 -0.46 1.17e-18 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs16976116 0.901 rs28589609 chr15:55503630 C/T cg11288833 chr15:55489084 RSL24D1 0.5 5.93 0.31 7.52e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs6951245 0.554 rs11544331 chr7:1131411 C/T cg13565492 chr6:43139072 SRF -0.74 -10.74 -0.51 2.65e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg23978390 chr7:1156363 C7orf50 0.43 5.93 0.31 7.56e-9 Longevity;Endometriosis; LUSC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg17294928 chr15:75287854 SCAMP5 0.48 7.16 0.36 5.3e-12 Breast cancer; LUSC cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs61931739 0.500 rs11053242 chr12:34511625 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.19e-33 Morning vs. evening chronotype; LUSC cis rs877282 0.898 rs11253348 chr10:765852 C/T cg17470449 chr10:769945 NA 0.53 7.08 0.36 8.43e-12 Uric acid levels; LUSC cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg06627628 chr2:24431161 ITSN2 -0.6 -7.35 -0.37 1.56e-12 Lymphocyte counts; LUSC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg20203395 chr5:56204925 C5orf35 0.56 8.05 0.4 1.43e-14 Initial pursuit acceleration; LUSC cis rs7773004 0.601 rs13210340 chr6:26326314 G/C cg16898833 chr6:26189333 HIST1H4D 0.79 6.09 0.32 3.19e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs6582630 0.519 rs2387812 chr12:38381480 A/G cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.55e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg22834771 chr12:69754056 YEATS4 -0.54 -8.08 -0.4 1.23e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.99 -0.31 5.31e-9 Reticulocyte fraction of red cells; LUSC cis rs4144743 0.759 rs16969966 chr17:45318452 G/T cg18085866 chr17:45331354 ITGB3 -0.66 -6.56 -0.34 2.02e-10 Body mass index; LUSC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.23e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2361710 1.000 rs2361710 chr17:78111877 C/T cg06718696 chr17:78121285 EIF4A3 -0.5 -7.72 -0.39 1.41e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs10876993 0.928 rs2640631 chr12:58067532 A/T cg15848620 chr12:58087721 OS9 -0.53 -7.75 -0.39 1.13e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg00677455 chr12:58241039 CTDSP2 0.7 10.51 0.5 1.69e-22 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs11190602 chr10:102297256 T/C cg07080220 chr10:102295463 HIF1AN 0.69 9.38 0.46 1.06e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1372520 0.873 rs983361 chr4:90761944 T/G cg15133208 chr4:90757351 SNCA -0.54 -8.18 -0.41 6.05e-15 Neuroticism; LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg20608306 chr11:116969690 SIK3 0.41 6.75 0.35 6.72e-11 Blood protein levels; LUSC cis rs1728785 1.000 rs7196104 chr16:68579746 C/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.54 -0.42 4.65e-16 Personality dimensions; LUSC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs4499344 0.920 rs752719 chr19:33086091 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.6 -7.86 -0.4 5.19e-14 Mean platelet volume; LUSC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.41 -0.38 1.02e-12 Developmental language disorder (linguistic errors); LUSC cis rs9911578 1.000 rs12938772 chr17:56776320 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.88 0.35 2.9e-11 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.3 0.56 6.22e-29 Motion sickness; LUSC cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg13010199 chr12:38710504 ALG10B 0.65 10.01 0.48 8.37e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg14582100 chr15:45693742 SPATA5L1 0.58 10.64 0.5 5.72e-23 Homoarginine levels; LUSC cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg20503657 chr10:835505 NA -0.51 -6.97 -0.36 1.73e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs6121246 0.520 rs6060425 chr20:30224355 C/T cg18721089 chr20:30220636 NA -0.38 -6.22 -0.32 1.49e-9 Mean corpuscular hemoglobin; LUSC cis rs75804782 0.641 rs11902599 chr2:239348400 C/T cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.33e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs67072384 1.000 rs7128364 chr11:72451941 A/C cg04827223 chr11:72435913 ARAP1 -0.82 -7.39 -0.37 1.22e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs2014572 0.967 rs10418480 chr19:57755055 C/T cg24459738 chr19:57751996 ZNF805 -0.54 -8.1 -0.41 1.06e-14 Hyperactive-impulsive symptoms; LUSC cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.16 -0.45 5.39e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7809615 0.551 rs952319 chr7:99171449 C/T cg24650262 chr7:98904301 NA 0.5 6.27 0.32 1.09e-9 Blood metabolite ratios; LUSC cis rs7084402 1.000 rs7084402 chr10:60265404 C/T cg07615347 chr10:60278583 BICC1 0.36 5.76 0.3 1.93e-8 Refractive error; LUSC cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg23583168 chr7:148888333 NA -0.82 -14.69 -0.63 5.05e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg08280861 chr8:58055591 NA 0.54 5.8 0.3 1.52e-8 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs77619190 chr4:97991906 C/A cg09670535 chr1:18959427 PAX7 -0.64 -6.12 -0.32 2.68e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.64 -13.35 -0.59 6.98e-33 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2898681 0.561 rs7699960 chr4:53735661 C/A cg00791764 chr4:53727839 RASL11B 0.57 7.88 0.4 4.76e-14 Optic nerve measurement (cup area); LUSC cis rs6686643 1.000 rs957644 chr1:165616157 C/T cg16553119 chr1:165599451 MGST3 -0.46 -6.79 -0.35 5.1e-11 Total ventricular volume; LUSC cis rs2742234 0.541 rs11238479 chr10:43717423 C/T cg02780029 chr10:43622663 RET 0.34 5.67 0.3 3.03e-8 Hirschsprung disease; LUSC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg06074448 chr4:187884817 NA 0.39 6.49 0.33 3.04e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg00290607 chr11:67383545 NA -0.36 -6.39 -0.33 5.41e-10 Mean corpuscular volume; LUSC trans rs10506458 0.834 rs73127067 chr12:63390333 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.07 -0.64 1.64e-39 Hemostatic factors and hematological phenotypes; LUSC cis rs11018904 0.906 rs35129016 chr11:89948689 T/C cg26028595 chr11:89956573 CHORDC1 -0.52 -5.88 -0.31 9.96e-9 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26509722 chr12:6833059 COPS7A 0.45 6.11 0.32 2.8e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg04944784 chr2:26401820 FAM59B 0.67 8.82 0.43 6.53e-17 Gut microbiome composition (summer); LUSC cis rs765787 0.530 rs1706835 chr15:45517884 G/A cg25801113 chr15:45476975 SHF 0.35 7.3 0.37 2.15e-12 Uric acid levels; LUSC cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg23711669 chr6:146136114 FBXO30 0.87 16.13 0.66 1.08e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg19774624 chr17:42201019 HDAC5 -0.79 -12.74 -0.57 1.48e-30 Total body bone mineral density; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05654483 chr10:122610929 WDR11 -0.47 -6.31 -0.33 8.82e-10 Bipolar disorder and schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24836204 chr8:144450966 RHPN1;C8orf51 -0.46 -7.16 -0.36 5.17e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs921968 0.541 rs3731867 chr2:219472734 G/A cg02176678 chr2:219576539 TTLL4 -0.75 -14.09 -0.61 1.01e-35 Mean corpuscular hemoglobin concentration; LUSC cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg24642439 chr20:33292090 TP53INP2 0.63 9.83 0.47 3.51e-20 Coronary artery disease; LUSC cis rs2281845 0.507 rs942703 chr1:201092979 A/G cg06714761 chr1:201096289 NA -0.43 -7.99 -0.4 2.21e-14 Permanent tooth development; LUSC cis rs400736 0.655 rs11121086 chr1:8151224 C/T cg25007680 chr1:8021821 PARK7 -0.45 -6.8 -0.35 4.94e-11 Response to antidepressants and depression; LUSC cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg08975724 chr8:8085496 FLJ10661 0.51 7.94 0.4 3.05e-14 Mood instability; LUSC cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.5 8.43 0.42 1.07e-15 Axial length; LUSC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 11.17 0.52 7.62e-25 Platelet count; LUSC cis rs616402 0.527 rs589151 chr1:10567711 C/T cg17425144 chr1:10567563 PEX14 0.64 13.33 0.59 8.73e-33 Breast size; LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 16.09 0.66 1.53e-43 Platelet count; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.03 0.4 1.66e-14 Prudent dietary pattern; LUSC cis rs2439831 0.867 rs16957627 chr15:43642657 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs7296418 0.922 rs12425009 chr12:123502044 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -7.17 -0.37 4.8e-12 Platelet count; LUSC cis rs7615316 0.934 rs4273389 chr3:142213930 A/G cg16271453 chr3:142027066 XRN1 -0.4 -6.87 -0.35 3.22e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4727027 0.704 rs12704070 chr7:148902789 G/A cg23158103 chr7:148848205 ZNF398 -0.49 -8.32 -0.41 2.32e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg18904891 chr8:8559673 CLDN23 0.38 5.91 0.31 8.65e-9 Mood instability; LUSC cis rs9768139 0.708 rs11769028 chr7:158113881 G/A cg24154853 chr7:158122151 PTPRN2 0.45 8.8 0.43 7.55e-17 Calcium levels; LUSC cis rs68170813 0.652 rs7807154 chr7:107161391 T/G cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs2901656 0.701 rs4916266 chr1:172450795 G/T cg03748243 chr1:172413542 C1orf105;PIGC 0.3 5.85 0.3 1.18e-8 Red cell distribution width;Platelet distribution width; LUSC cis rs7824557 0.701 rs4568582 chr8:11160495 A/T cg21775007 chr8:11205619 TDH 0.71 11.49 0.53 5.55e-26 Retinal vascular caliber; LUSC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg26566898 chr11:117069891 TAGLN 0.45 7.86 0.39 5.45e-14 Blood protein levels; LUSC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg25039879 chr17:56429692 SUPT4H1 0.73 10.46 0.5 2.52e-22 Cognitive test performance; LUSC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.59 0.5 8.66e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9527 0.590 rs10786738 chr10:104869451 C/T cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs9467711 0.651 rs7749414 chr6:26074884 G/T cg08501292 chr6:25962987 TRIM38 0.66 5.92 0.31 7.96e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg04034577 chr2:241836375 C2orf54 -0.49 -8.92 -0.44 3.11e-17 Urinary metabolites; LUSC cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg26384229 chr12:38710491 ALG10B 0.92 17.62 0.69 1.4e-49 Heart rate; LUSC cis rs1994135 0.647 rs11052745 chr12:33695999 G/T cg06521331 chr12:34319734 NA -0.38 -5.66 -0.3 3.3e-8 Resting heart rate; LUSC cis rs1775715 0.737 rs2799012 chr10:32103077 C/T cg03015672 chr10:32216066 ARHGAP12 0.33 5.84 0.3 1.22e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6688613 0.685 rs6427047 chr1:166914258 A/G cg07049167 chr1:166818506 POGK 0.46 6.79 0.35 5.2e-11 Refractive astigmatism; LUSC cis rs208520 0.802 rs208516 chr6:66946119 T/C cg07460842 chr6:66804631 NA -1.01 -14.32 -0.62 1.29e-36 Exhaled nitric oxide output; LUSC cis rs1568889 1.000 rs7931847 chr11:28175245 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.6 8.62 0.43 2.71e-16 Bipolar disorder; LUSC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11890956 chr21:40555474 PSMG1 -0.91 -16.14 -0.66 9.77e-44 Cognitive function; LUSC cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC cis rs7089973 0.624 rs17586888 chr10:116598121 T/C cg23260525 chr10:116636907 FAM160B1 0.43 9.23 0.45 3.24e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg10053473 chr17:62856997 LRRC37A3 0.65 10.22 0.49 1.69e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs193541 0.632 rs2407402 chr5:122107105 G/C cg19077854 chr5:122220652 SNX24 0.38 7.9 0.4 4.04e-14 Glucose homeostasis traits; LUSC cis rs599083 0.590 rs10791984 chr11:68407835 T/G cg01657329 chr11:68192670 LRP5 0.38 5.78 0.3 1.75e-8 Bone mineral density (spine); LUSC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg08470875 chr2:26401718 FAM59B -0.65 -8.87 -0.44 4.58e-17 Gut microbiome composition (summer); LUSC trans rs12210905 0.688 rs12205044 chr6:27478990 A/G cg11837749 chr1:55047332 ACOT11 0.7 6.03 0.31 4.34e-9 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -7.22 -0.37 3.59e-12 Lung cancer; LUSC cis rs72781680 0.800 rs56398785 chr2:24091515 T/A cg20701182 chr2:24300061 SF3B14 0.75 7.67 0.39 1.89e-13 Lymphocyte counts; LUSC cis rs78572108 0.777 rs72613888 chr2:42267941 C/T cg00607755 chr2:42274082 PKDCC 0.34 5.83 0.3 1.28e-8 Total body bone mineral density; LUSC trans rs2562456 0.520 rs660063 chr19:21453905 T/G cg00806126 chr19:22604979 ZNF98 0.43 6.14 0.32 2.37e-9 Pain; LUSC cis rs7666738 0.546 rs13141117 chr4:98892798 G/A cg17366294 chr4:99064904 C4orf37 0.53 8.57 0.42 3.77e-16 Colonoscopy-negative controls vs population controls; LUSC trans rs3960554 0.800 rs112463197 chr7:75622912 C/T cg19862616 chr7:65841803 NCRNA00174 0.88 9.85 0.47 2.92e-20 Eotaxin levels; LUSC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs9311676 0.656 rs7647078 chr3:58369912 C/T cg26110898 chr3:58419937 PDHB 0.42 6.72 0.35 7.93e-11 Systemic lupus erythematosus; LUSC cis rs897984 0.542 rs6565217 chr16:31083324 C/T cg02466173 chr16:30829666 NA -0.48 -9.19 -0.45 4.22e-18 Dementia with Lewy bodies; LUSC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.77 9.4 0.46 9.26e-19 Gut microbiome composition (summer); LUSC cis rs9494145 0.680 rs35959442 chr6:135424179 C/G cg22676075 chr6:135203613 NA 0.6 8.76 0.43 9.63e-17 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg26647111 chr11:31128758 NA -0.41 -5.94 -0.31 7.27e-9 Red blood cell count; LUSC cis rs9902453 0.845 rs7221516 chr17:28232506 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.38 0.53 1.44e-25 Coffee consumption (cups per day); LUSC cis rs7208859 0.623 rs1054400 chr17:29109954 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs12541635 0.677 rs7846149 chr8:107053417 T/C cg10147462 chr8:107024639 NA 0.66 13.82 0.6 1.17e-34 Age of smoking initiation; LUSC cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs367943 0.966 rs364738 chr5:112808329 A/G cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs7089973 0.624 rs10885613 chr10:116589400 G/A cg25233709 chr10:116636983 FAM160B1 0.37 6.59 0.34 1.69e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg16339924 chr4:17578868 LAP3 0.66 10.14 0.48 3.16e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17270561 0.609 rs9356985 chr6:25728098 C/T cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC cis rs7089973 0.604 rs11196937 chr10:116589500 G/C cg23260525 chr10:116636907 FAM160B1 0.43 9.21 0.45 3.72e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg25039879 chr17:56429692 SUPT4H1 0.66 8.81 0.43 6.99e-17 Cognitive test performance; LUSC cis rs7843479 1.000 rs13248727 chr8:21842063 T/C cg17168535 chr8:21777572 XPO7 0.64 9.82 0.47 3.68e-20 Mean corpuscular volume; LUSC trans rs12439619 0.846 rs62013464 chr15:82580591 A/C cg04831495 chr15:85060580 GOLGA6L5 -0.48 -6.55 -0.34 2.15e-10 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05367846 chr22:18507520 MICAL3 0.44 7.14 0.36 5.79e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs897984 0.806 rs4889571 chr16:30949047 A/G cg02466173 chr16:30829666 NA 0.57 11.43 0.53 9.44e-26 Dementia with Lewy bodies; LUSC cis rs8058578 0.832 rs7500719 chr16:30840877 C/T cg02466173 chr16:30829666 NA -0.56 -10.49 -0.5 1.97e-22 Multiple myeloma; LUSC cis rs72634258 0.786 rs6577468 chr1:8183921 T/C cg26816564 chr1:7831052 VAMP3 0.45 5.75 0.3 1.98e-8 Inflammatory bowel disease; LUSC trans rs6952808 1.000 rs6978048 chr7:1886872 T/G cg24247370 chr13:99142703 STK24 -0.34 -6.17 -0.32 1.96e-9 Bipolar disorder and schizophrenia; LUSC trans rs561341 1.000 rs72821952 chr17:30248133 T/A cg20587970 chr11:113659929 NA -1.3 -16.21 -0.66 5.22e-44 Hip circumference adjusted for BMI; LUSC cis rs7746199 0.736 rs17750424 chr6:27701122 T/C cg26958806 chr6:27640298 NA 0.74 6.04 0.31 4.02e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg24110177 chr3:50126178 RBM5 -0.55 -8.99 -0.44 1.87e-17 Intelligence (multi-trait analysis); LUSC cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg23029597 chr12:123009494 RSRC2 -0.76 -10.16 -0.49 2.57e-21 Body mass index; LUSC cis rs2439831 0.717 rs2447198 chr15:43895118 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.83 8.73 0.43 1.26e-16 Lung cancer in ever smokers; LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.2 0.37 3.91e-12 Platelet count; LUSC cis rs4629710 0.545 rs11154621 chr6:131547341 A/G cg12700074 chr6:131571435 AKAP7 -0.33 -5.65 -0.3 3.4e-8 Multiple myeloma (IgH translocation); LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg08859206 chr1:53392774 SCP2 0.5 8.6 0.43 3.21e-16 Monocyte count; LUSC trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg03929089 chr4:120376271 NA 0.7 7.85 0.39 5.6e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg20684491 chr1:25596433 NA -0.37 -5.77 -0.3 1.84e-8 Erythrocyte sedimentation rate; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.57 -0.5 1.04e-22 Alzheimer's disease; LUSC cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg27129171 chr3:47204927 SETD2 -0.68 -11.39 -0.53 1.3e-25 Colorectal cancer; LUSC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.55 -0.34 2.2e-10 Alzheimer's disease (late onset); LUSC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg17747265 chr1:1875780 NA -0.73 -16.86 -0.68 1.44e-46 Body mass index; LUSC cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.11e-21 Bladder cancer; LUSC cis rs9527 0.569 rs78193706 chr10:104780564 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.15e-10 Arsenic metabolism; LUSC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg11189052 chr15:85197271 WDR73 0.67 10.2 0.49 1.95e-21 P wave terminal force; LUSC cis rs988712 0.587 rs117567901 chr11:27706040 T/C cg10635145 chr11:27742435 BDNF -0.46 -6.24 -0.32 1.36e-9 Obesity; LUSC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg03264133 chr6:25882463 NA -0.59 -9.77 -0.47 5.45e-20 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg26441486 chr22:50317300 CRELD2 -0.54 -8.25 -0.41 3.75e-15 Schizophrenia; LUSC cis rs367615 0.660 rs10477972 chr5:108831951 C/A cg17395555 chr5:108820864 NA 0.64 11.37 0.53 1.52e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs10779751 0.922 rs11121708 chr1:11307253 G/C cg08854313 chr1:11322531 MTOR 0.87 14.95 0.63 4.62e-39 Body mass index; LUSC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg27539214 chr16:67997921 SLC12A4 -0.59 -7.7 -0.39 1.52e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg13047869 chr3:10149882 C3orf24 0.64 8.79 0.43 8.31e-17 Alzheimer's disease; LUSC cis rs12368653 0.651 rs2307097 chr12:58195801 T/C cg00677455 chr12:58241039 CTDSP2 -0.42 -5.78 -0.3 1.73e-8 Multiple sclerosis; LUSC cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.23 -0.37 3.33e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7254114 0.578 rs6511727 chr19:11315817 G/T cg02815516 chr19:11306319 KANK2 -0.39 -7.92 -0.4 3.44e-14 Immature fraction of reticulocytes; LUSC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg09455208 chr3:40491958 NA 0.53 9.39 0.46 9.5e-19 Renal cell carcinoma; LUSC cis rs3740713 0.748 rs35292478 chr11:18429991 A/C cg23797887 chr11:18477753 LDHAL6A -0.54 -6.62 -0.34 1.44e-10 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg03351412 chr1:154909251 PMVK -0.55 -8.69 -0.43 1.62e-16 Prostate cancer; LUSC trans rs613391 0.736 rs3012992 chr9:22647014 C/T cg05038977 chr17:7476167 EIF4A1 0.4 6.11 0.32 2.81e-9 Quantitative traits; LUSC cis rs12594515 1.000 rs6493176 chr15:45990026 A/G cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC trans rs6598955 0.616 rs11247890 chr1:26590182 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg07701084 chr6:150067640 NUP43 0.57 8.71 0.43 1.47e-16 Lung cancer; LUSC cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.67 0.65 7.43e-42 Bladder cancer; LUSC cis rs6545883 0.894 rs6760075 chr2:61612881 C/A cg15711740 chr2:61764176 XPO1 0.43 6.7 0.34 8.66e-11 Tuberculosis; LUSC trans rs2587949 0.571 rs2600136 chr3:4208947 T/C cg15139668 chr4:4577005 NA -0.41 -6.03 -0.31 4.44e-9 Periodontitis (DPAL); LUSC cis rs4948102 0.642 rs6593297 chr7:56122058 A/T cg17215666 chr7:56131930 SUMF2 -0.43 -5.86 -0.31 1.11e-8 Plasma homocysteine levels (post-methionine load test); LUSC cis rs7215564 0.908 rs80183474 chr17:78655070 T/A cg09596252 chr17:78655493 RPTOR 0.55 5.92 0.31 7.92e-9 Myopia (pathological); LUSC cis rs61861422 0.516 rs12412216 chr10:134393338 C/T cg20090690 chr10:134436459 INPP5A 0.48 5.91 0.31 8.35e-9 Primary sclerosing cholangitis; LUSC cis rs9399135 0.967 rs17638970 chr6:135320063 A/G cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Red blood cell count; LUSC cis rs3741404 0.574 rs616563 chr11:63877501 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.43 6.8 0.35 4.78e-11 Platelet count; LUSC cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg03146154 chr1:46216737 IPP 0.51 7.63 0.39 2.44e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs3126085 0.935 rs11204952 chr1:152227321 G/A cg26876637 chr1:152193138 HRNR 0.43 6.11 0.32 2.71e-9 Atopic dermatitis; LUSC cis rs7000551 0.779 rs2443507 chr8:22373231 G/A cg12081754 chr8:22256438 SLC39A14 0.42 6.24 0.32 1.3e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8072100 0.840 rs56952963 chr17:45493826 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.84 -0.3 1.22e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.42 6.41 0.33 4.84e-10 Intelligence (multi-trait analysis); LUSC cis rs921968 0.608 rs7598056 chr2:219352511 A/C cg02176678 chr2:219576539 TTLL4 0.64 11.55 0.53 3.54e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs2637266 0.756 rs7079818 chr10:78469935 T/A cg18941641 chr10:78392320 NA 0.35 6.25 0.32 1.26e-9 Pulmonary function; LUSC cis rs262150 0.625 rs55974535 chr7:158769145 C/G cg19418458 chr7:158789849 NA 0.58 7.18 0.37 4.59e-12 Facial morphology (factor 20); LUSC trans rs9951602 0.512 rs9946123 chr18:76654557 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.05 0.58 9.85e-32 Obesity-related traits; LUSC cis rs28785552 1.000 rs28785552 chr19:53234161 G/A cg10871876 chr19:53194124 ZNF83 0.55 8.35 0.42 1.91e-15 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg16339924 chr4:17578868 LAP3 0.63 9.88 0.48 2.3e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1577917 1.000 rs12203493 chr6:86758642 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.46 -0.42 8.72e-16 Response to antipsychotic treatment; LUSC cis rs4664308 0.740 rs877635 chr2:160902847 A/C cg03641300 chr2:160917029 PLA2R1 -0.39 -6.0 -0.31 5.24e-9 Idiopathic membranous nephropathy; LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.85 -0.66 1.37e-42 Gut microbiome composition (summer); LUSC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg08439880 chr3:133502540 NA -0.33 -5.94 -0.31 7.34e-9 Iron status biomarkers; LUSC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.49e-15 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs1994135 0.586 rs7308214 chr12:33713834 T/A cg06521331 chr12:34319734 NA -0.38 -5.66 -0.3 3.31e-8 Resting heart rate; LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg08859206 chr1:53392774 SCP2 0.52 9.03 0.44 1.35e-17 Monocyte count; LUSC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.31 -0.37 2.02e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg20302533 chr7:39170763 POU6F2 0.55 9.13 0.45 6.58e-18 IgG glycosylation; LUSC cis rs9527 0.544 rs3781280 chr10:104863843 T/G cg05855489 chr10:104503620 C10orf26 0.53 8.1 0.41 1.05e-14 Arsenic metabolism; LUSC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg23172400 chr8:95962367 TP53INP1 -0.41 -8.5 -0.42 6.24e-16 Type 2 diabetes; LUSC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg15445000 chr17:37608096 MED1 -0.39 -6.73 -0.35 7.47e-11 Glomerular filtration rate (creatinine); LUSC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.33 0.41 2.12e-15 Height; LUSC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22509189 chr2:225307070 NA 0.44 5.77 0.3 1.81e-8 IgE levels in asthmatics (D.p. specific); LUSC cis rs78545713 0.649 rs79662647 chr6:26217845 G/A cg23601095 chr6:26197514 HIST1H3D 0.69 5.72 0.3 2.34e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg02782426 chr3:40428986 ENTPD3 0.41 7.76 0.39 1.02e-13 Renal cell carcinoma; LUSC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.69 0.75 8.44e-62 Homoarginine levels; LUSC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg04865166 chr7:105162814 PUS7 0.52 5.69 0.3 2.74e-8 Bipolar disorder (body mass index interaction); LUSC cis rs1878931 0.582 rs10048083 chr16:3417465 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.6 8.37 0.42 1.62e-15 Body mass index (adult); LUSC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.47 -9.16 -0.45 5.39e-18 Monocyte percentage of white cells; LUSC trans rs6951245 0.554 rs79367977 chr7:1152657 G/A cg13565492 chr6:43139072 SRF -0.72 -10.91 -0.51 6.55e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11608355 0.515 rs12579916 chr12:109924528 T/G cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.92 -0.35 2.28e-11 Menopause (age at onset); LUSC cis rs968451 0.813 rs5757619 chr22:39724558 G/A cg17798944 chr22:39715225 SNORD43;RPL3 0.66 8.7 0.43 1.5e-16 Primary biliary cholangitis; LUSC cis rs6460942 0.591 rs62448729 chr7:12333720 G/C cg06484146 chr7:12443880 VWDE -0.56 -5.89 -0.31 9.39e-9 Coronary artery disease; LUSC cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.83 -0.51 1.23e-23 Alzheimer's disease (late onset); LUSC cis rs7147624 1.000 rs7160390 chr14:66052460 G/A cg03016385 chr14:66212404 NA -0.84 -9.37 -0.46 1.12e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg23711669 chr6:146136114 FBXO30 0.78 12.85 0.58 5.36e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs782590 0.556 rs782579 chr2:55917604 A/G cg03859395 chr2:55845619 SMEK2 0.67 10.82 0.51 1.32e-23 Metabolic syndrome; LUSC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg00933542 chr6:150070202 PCMT1 0.32 6.79 0.35 5.14e-11 Lung cancer; LUSC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg00031303 chr3:195681400 NA 0.67 9.55 0.46 2.79e-19 Pancreatic cancer; LUSC cis rs600231 0.623 rs587080 chr11:65253800 A/C cg17120908 chr11:65337727 SSSCA1 -0.53 -9.23 -0.45 3.09e-18 Bone mineral density; LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg04844267 chr4:1394941 NA 0.29 5.69 0.3 2.84e-8 Obesity-related traits; LUSC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg24977027 chr2:88469347 THNSL2 0.56 5.93 0.31 7.76e-9 Plasma clusterin levels; LUSC trans rs6502050 0.835 rs4789678 chr17:80101078 C/T cg07393940 chr7:158741817 NA 0.37 6.75 0.35 6.53e-11 Life satisfaction; LUSC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg08439880 chr3:133502540 NA -0.34 -6.07 -0.32 3.55e-9 Iron status biomarkers; LUSC cis rs2404602 0.735 rs11857015 chr15:76649390 T/C cg23625390 chr15:77176239 SCAPER -0.6 -9.24 -0.45 2.9e-18 Blood metabolite levels; LUSC cis rs7089973 0.604 rs2420065 chr10:116583753 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.16 0.45 5.47e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs17401966 1.000 rs7520651 chr1:10329872 G/A cg19773385 chr1:10388646 KIF1B -0.54 -8.39 -0.42 1.42e-15 Hepatocellular carcinoma; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg11060661 chr22:24314208 DDT;DDTL -0.46 -6.29 -0.33 9.84e-10 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg03806693 chr22:41940476 POLR3H 1.01 14.49 0.62 2.93e-37 Vitiligo; LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg00814883 chr7:100076585 TSC22D4 -0.73 -9.8 -0.47 4.39e-20 Platelet count; LUSC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs10193935 0.582 rs13394853 chr2:42630900 T/C cg27598129 chr2:42591480 NA -0.61 -8.29 -0.41 2.79e-15 Colonoscopy-negative controls vs population controls; LUSC trans rs961253 0.501 rs6054145 chr20:6335730 T/C cg21095983 chr6:86352623 SYNCRIP 0.49 7.22 0.37 3.64e-12 Colorectal cancer; LUSC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg22800045 chr5:56110881 MAP3K1 0.43 6.02 0.31 4.49e-9 Coronary artery disease; LUSC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.73 0.35 7.58e-11 Lung cancer; LUSC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg05110241 chr16:68378359 PRMT7 -0.55 -6.32 -0.33 8.3e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg25456477 chr12:86230367 RASSF9 0.39 6.88 0.35 2.96e-11 Major depressive disorder; LUSC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg10057126 chr4:77819792 ANKRD56 -0.52 -7.88 -0.4 4.68e-14 Emphysema distribution in smoking; LUSC cis rs11864453 0.762 rs6416742 chr16:72149061 C/T cg16558253 chr16:72132732 DHX38 -0.44 -6.56 -0.34 2.07e-10 Fibrinogen levels; LUSC cis rs4588572 0.644 rs10061149 chr5:77744201 G/A cg11547950 chr5:77652471 NA -0.46 -6.87 -0.35 3.19e-11 Triglycerides; LUSC cis rs7223966 0.960 rs7212379 chr17:61706122 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 6.52 0.34 2.61e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg22681709 chr2:178499509 PDE11A -0.48 -8.23 -0.41 4.23e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg17971929 chr21:40555470 PSMG1 -0.51 -7.49 -0.38 6.3e-13 Menarche (age at onset); LUSC cis rs1451375 0.756 rs11761683 chr7:50542879 C/T cg18232548 chr7:50535776 DDC -0.6 -9.34 -0.46 1.39e-18 Malaria; LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.93e-29 Prudent dietary pattern; LUSC cis rs2742234 0.910 rs2505513 chr10:43633537 C/G cg15436174 chr10:43711423 RASGEF1A -0.37 -6.66 -0.34 1.16e-10 Hirschsprung disease; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg12419862 chr22:24373484 LOC391322 0.83 15.11 0.64 1.11e-39 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg06145435 chr7:1022769 CYP2W1 0.33 7.15 0.36 5.36e-12 Longevity;Endometriosis; LUSC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.87 -0.35 3.2e-11 Lung cancer; LUSC cis rs17401966 0.838 rs12139981 chr1:10390696 T/C cg19773385 chr1:10388646 KIF1B -0.5 -8.74 -0.43 1.18e-16 Hepatocellular carcinoma; LUSC cis rs17253792 0.822 rs2274075 chr14:56096731 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.52 0.42 5.74e-16 Height; LUSC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -6.47 -0.33 3.44e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg00149659 chr3:10157352 C3orf10 0.97 14.18 0.61 4.85e-36 Alzheimer's disease; LUSC cis rs877282 0.945 rs12776447 chr10:790625 A/G cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs59698941 0.709 rs12163973 chr5:132226664 G/A cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.45e-11 Apolipoprotein A-IV levels; LUSC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg12463550 chr7:65579703 CRCP 0.64 5.83 0.3 1.3e-8 Diabetic kidney disease; LUSC cis rs73200209 0.744 rs11615595 chr12:116470876 T/C cg01776926 chr12:116560359 MED13L -0.5 -6.0 -0.31 5.21e-9 Total body bone mineral density; LUSC cis rs7659604 0.540 rs11098643 chr4:122701507 C/A cg20573242 chr4:122745356 CCNA2 -0.46 -6.86 -0.35 3.36e-11 Type 2 diabetes; LUSC cis rs34734847 1.000 rs10431385 chr12:121128882 T/C cg21892295 chr12:121157589 UNC119B -0.45 -8.02 -0.4 1.78e-14 Mean corpuscular volume; LUSC trans rs11250098 0.541 rs6997997 chr8:10766082 T/C cg15556689 chr8:8085844 FLJ10661 -0.55 -7.73 -0.39 1.26e-13 Morning vs. evening chronotype; LUSC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg16423285 chr20:60520624 NA -0.47 -5.75 -0.3 2.06e-8 Body mass index; LUSC cis rs7927592 0.513 rs3853616 chr11:68198252 A/G cg01657329 chr11:68192670 LRP5 -0.5 -7.89 -0.4 4.32e-14 Total body bone mineral density; LUSC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg17507749 chr15:85114479 UBE2QP1 0.67 8.49 0.42 6.75e-16 Schizophrenia; LUSC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg04553112 chr3:125709451 NA -0.49 -5.86 -0.31 1.11e-8 Blood pressure (smoking interaction); LUSC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg15445000 chr17:37608096 MED1 0.4 6.86 0.35 3.35e-11 Glomerular filtration rate (creatinine); LUSC cis rs62103177 0.525 rs4799116 chr18:77736735 A/G cg02751453 chr18:77725136 HSBP1L1 0.43 5.93 0.31 7.5e-9 Opioid sensitivity; LUSC cis rs10744422 1.000 rs7139055 chr12:123364198 A/G cg25930673 chr12:123319894 HIP1R 0.68 6.87 0.35 3.06e-11 Schizophrenia; LUSC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg06008330 chr7:65541103 ASL -0.4 -6.2 -0.32 1.66e-9 Aortic root size; LUSC cis rs2120019 0.567 rs12385940 chr15:75168162 C/T cg17294928 chr15:75287854 SCAMP5 -0.76 -8.8 -0.43 7.3e-17 Blood trace element (Zn levels); LUSC cis rs1728785 1.000 rs1624718 chr16:68580385 A/G cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs599083 0.744 rs603129 chr11:68186669 A/T cg16797656 chr11:68205561 LRP5 -0.36 -5.81 -0.3 1.46e-8 Bone mineral density (spine); LUSC cis rs1997103 1.000 rs6593237 chr7:55411015 T/C cg17469321 chr7:55412551 NA 0.65 10.54 0.5 1.31e-22 QRS interval (sulfonylurea treatment interaction); LUSC trans rs9329221 0.537 rs6601414 chr8:9976748 G/A cg21775007 chr8:11205619 TDH 0.43 6.2 0.32 1.68e-9 Neuroticism; LUSC cis rs7582720 1.000 rs72934714 chr2:203711581 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs928736 0.557 rs2834083 chr21:34436973 A/G cg00274965 chr21:34405681 NA 0.29 5.66 0.3 3.24e-8 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs12973672 0.812 rs12979058 chr19:35750684 G/A cg12095397 chr19:35769544 USF2 0.43 6.55 0.34 2.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg26446133 chr18:72167187 CNDP2 -0.85 -13.48 -0.59 2.36e-33 Refractive error; LUSC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg18404041 chr3:52824283 ITIH1 -0.55 -10.53 -0.5 1.4e-22 Electroencephalogram traits; LUSC cis rs11711311 1.000 rs13073843 chr3:113449150 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC cis rs9796 0.621 rs2578655 chr15:41462809 T/G cg18705301 chr15:41695430 NDUFAF1 -0.52 -8.94 -0.44 2.78e-17 Menopause (age at onset); LUSC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.33 0.49 7e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12579753 1.000 rs11115017 chr12:82176914 C/A cg07923666 chr12:49932857 KCNH3 -0.51 -6.26 -0.32 1.15e-9 Resting heart rate; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.39 0.33 5.54e-10 Electroencephalogram traits; LUSC cis rs7582180 0.629 rs10202326 chr2:100950237 A/G cg12002119 chr2:101014098 CHST10 0.36 5.99 0.31 5.44e-9 Intelligence (multi-trait analysis); LUSC cis rs17270561 0.609 rs1317510 chr6:25778924 T/C cg17691542 chr6:26056736 HIST1H1C 0.5 6.93 0.35 2.21e-11 Iron status biomarkers; LUSC cis rs2742417 1.000 rs2673038 chr3:45748632 A/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.48e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg00677455 chr12:58241039 CTDSP2 0.59 8.65 0.43 2.25e-16 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.954 rs11098524 chr4:120390032 A/G cg24375607 chr4:120327624 NA 0.75 10.61 0.5 7.54e-23 Corneal astigmatism; LUSC cis rs950027 0.620 rs2453533 chr15:45641225 C/A cg26924012 chr15:45694286 SPATA5L1 0.78 12.42 0.56 2.27e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs7712401 0.601 rs35339188 chr5:122317685 A/T cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.46 0.53 7.03e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs55986470 0.670 rs56313033 chr2:239346202 C/T cg01134436 chr17:81009848 B3GNTL1 0.65 6.24 0.32 1.3e-9 Chronotype; LUSC cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC cis rs10911232 0.507 rs10911206 chr1:183012423 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.67e-24 Hypertriglyceridemia; LUSC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg16049864 chr8:95962084 TP53INP1 -0.64 -11.49 -0.53 5.57e-26 Type 2 diabetes; LUSC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg05623727 chr3:50126028 RBM5 0.31 5.82 0.3 1.37e-8 Body mass index; LUSC trans rs12310956 0.532 rs10844707 chr12:33936089 T/C cg13010199 chr12:38710504 ALG10B 0.56 8.52 0.42 5.71e-16 Morning vs. evening chronotype; LUSC cis rs7582720 1.000 rs72934573 chr2:204005072 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 8.78 0.43 8.34e-17 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs738322 0.555 rs6001027 chr22:38545619 A/G cg25457927 chr22:38595422 NA -0.42 -8.38 -0.42 1.53e-15 Cutaneous nevi; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15680975 chr20:3870297 PANK2 -0.41 -6.21 -0.32 1.57e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg22029157 chr1:209979665 IRF6 0.6 9.87 0.48 2.53e-20 Monobrow; LUSC cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.76 0.84 8.98e-89 Chronic sinus infection; LUSC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg13939156 chr17:80058883 NA 0.34 6.54 0.34 2.35e-10 Life satisfaction; LUSC trans rs9388451 0.839 rs4897157 chr6:126102981 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.34 -0.46 1.38e-18 Brugada syndrome; LUSC cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg04511125 chr2:88470314 THNSL2 0.65 6.17 0.32 1.98e-9 Plasma clusterin levels; LUSC cis rs6429082 0.608 rs4659838 chr1:235565315 A/G cg26050004 chr1:235667680 B3GALNT2 -0.51 -6.96 -0.36 1.77e-11 Adiposity; LUSC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg13319975 chr6:146136371 FBXO30 0.7 11.14 0.52 9.86e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs11792861 0.530 rs1772047 chr9:111679012 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.46 -7.1 -0.36 7.58e-12 Menarche (age at onset); LUSC cis rs208515 0.560 rs207084 chr6:66776966 T/C cg07460842 chr6:66804631 NA -1.22 -25.51 -0.81 1.96e-80 Exhaled nitric oxide levels; LUSC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg17173187 chr15:85201210 NMB 0.37 6.56 0.34 2.08e-10 Schizophrenia; LUSC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.26 0.41 3.35e-15 Hemoglobin concentration; LUSC cis rs61931739 0.500 rs11053269 chr12:34545307 A/G cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs11971779 0.680 rs10229358 chr7:139052545 C/T cg07862535 chr7:139043722 LUC7L2 -0.55 -6.92 -0.35 2.32e-11 Diisocyanate-induced asthma; LUSC cis rs2227930 0.506 rs13067197 chr3:142033531 G/A cg16271453 chr3:142027066 XRN1 -0.55 -9.86 -0.47 2.71e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg09455208 chr3:40491958 NA 0.59 10.51 0.5 1.59e-22 Renal cell carcinoma; LUSC cis rs6121246 0.567 rs6060295 chr20:30198473 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.3 -0.33 9.21e-10 Mean corpuscular hemoglobin; LUSC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg05855489 chr10:104503620 C10orf26 0.6 9.5 0.46 4.33e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg05564831 chr3:52568323 NT5DC2 -0.31 -5.86 -0.31 1.13e-8 Electroencephalogram traits; LUSC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg19230755 chr7:65878503 NA -0.41 -5.75 -0.3 2e-8 Aortic root size; LUSC cis rs10875746 1.000 rs10875746 chr12:48518264 A/C cg13454099 chr12:49076203 C12orf41 -0.49 -6.15 -0.32 2.26e-9 Longevity (90 years and older); LUSC cis rs752010 0.630 rs11210507 chr1:42105488 T/C cg06885757 chr1:42089581 HIVEP3 0.44 8.68 0.43 1.78e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7605827 0.897 rs9973344 chr2:15632583 G/T cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.79e-17 Educational attainment (years of education); LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.59 -0.5 8.72e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2439831 0.702 rs28699233 chr15:44122866 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.95 8.94 0.44 2.66e-17 Lung cancer in ever smokers; LUSC cis rs7903847 0.642 rs11189174 chr10:99139600 C/G cg08345082 chr10:99160200 RRP12 -0.37 -7.46 -0.38 7.51e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs34779708 0.801 rs12098720 chr10:35538683 G/A cg03585969 chr10:35415529 CREM 0.55 7.67 0.39 1.92e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg09849774 chr21:43526787 UMODL1;C21orf128 -0.42 -6.09 -0.32 3.15e-9 IgG glycosylation; LUSC cis rs1670533 0.872 rs11727135 chr4:1051803 G/C cg02018176 chr4:1364513 KIAA1530 0.46 6.33 0.33 7.73e-10 Recombination rate (females); LUSC cis rs73206853 0.841 rs3893403 chr12:111083980 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 6.66 0.34 1.12e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.88 0.44 4.25e-17 Prudent dietary pattern; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg24846343 chr22:24311635 DDTL 0.66 14.66 0.63 6.47e-38 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs35110281 0.666 rs2236665 chr21:45108987 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.61 0.5 7.44e-23 Mean corpuscular volume; LUSC cis rs6704644 0.656 rs11681704 chr2:234338402 G/A cg05711037 chr2:234359783 DGKD 0.58 6.14 0.32 2.36e-9 Bilirubin levels; LUSC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg12432903 chr7:1882776 MAD1L1 -0.53 -6.61 -0.34 1.55e-10 Bipolar disorder; LUSC cis rs950776 0.518 rs12591557 chr15:78811732 A/G cg06917634 chr15:78832804 PSMA4 0.82 14.7 0.63 4.46e-38 Sudden cardiac arrest; LUSC cis rs66887589 0.592 rs62320740 chr4:120279486 C/A cg13609457 chr4:120235615 NA 0.38 5.76 0.3 1.87e-8 Diastolic blood pressure; LUSC cis rs2439831 0.571 rs2470121 chr15:43937618 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC cis rs12421382 0.592 rs2029297 chr11:109465968 A/G cg27471124 chr11:109292789 C11orf87 0.41 7.15 0.36 5.5e-12 Schizophrenia; LUSC cis rs3126085 0.825 rs10788830 chr1:152206898 A/C cg26876637 chr1:152193138 HRNR 0.46 6.57 0.34 1.89e-10 Atopic dermatitis; LUSC cis rs4948102 0.924 rs13241866 chr7:56090878 C/G cg17215666 chr7:56131930 SUMF2 0.5 6.84 0.35 3.7e-11 Plasma homocysteine levels (post-methionine load test); LUSC cis rs8060686 0.623 rs74024145 chr16:68153382 G/C cg09835421 chr16:68378352 PRMT7 -0.44 -5.78 -0.3 1.69e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs929354 0.935 rs1182392 chr7:157036200 C/T cg05182265 chr7:156933206 UBE3C 0.44 6.88 0.35 2.95e-11 Body mass index; LUSC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg17554472 chr22:41940697 POLR3H -0.48 -5.94 -0.31 7.16e-9 Vitiligo; LUSC cis rs7246657 0.722 rs958305 chr19:38189440 A/G cg23950597 chr19:37808831 NA 0.5 5.64 0.3 3.55e-8 Coronary artery calcification; LUSC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg22920501 chr2:26401640 FAM59B -0.73 -10.61 -0.5 7.14e-23 Gut microbiome composition (summer); LUSC trans rs11098499 0.863 rs11723090 chr4:120490592 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.13 0.41 8.28e-15 Corneal astigmatism; LUSC trans rs911555 0.504 rs4444269 chr14:104072724 G/C cg03785828 chr5:81573306 RPS23 -0.37 -5.99 -0.31 5.58e-9 Intelligence (multi-trait analysis); LUSC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg13393036 chr8:95962371 TP53INP1 -0.36 -6.76 -0.35 6.1e-11 Type 2 diabetes; LUSC cis rs72781680 1.000 rs72796327 chr2:24140372 T/C cg08917208 chr2:24149416 ATAD2B 1.01 10.6 0.5 7.75e-23 Lymphocyte counts; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20024953 chr12:57584802 LRP1 -0.7 -6.27 -0.32 1.14e-9 Cognitive performance; LUSC cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.71 0.39 1.47e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg23583168 chr7:148888333 NA -0.87 -15.8 -0.65 2.3e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9811920 0.770 rs4928237 chr3:99731330 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 6.02 0.31 4.51e-9 Axial length; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.01 0.77 5.62e-67 Prudent dietary pattern; LUSC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg24733560 chr20:60626293 TAF4 0.41 6.7 0.34 8.69e-11 Body mass index; LUSC cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.61 9.09 0.45 9.18e-18 Menarche (age at onset); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07017284 chr1:173684020 KLHL20 0.34 6.0 0.31 5.13e-9 Triglycerides; LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.49 -0.33 3.04e-10 Developmental language disorder (linguistic errors); LUSC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg05896524 chr21:47604654 C21orf56 0.45 6.78 0.35 5.51e-11 Testicular germ cell tumor; LUSC trans rs7833787 0.725 rs12544660 chr8:18678404 C/T cg25885280 chr11:70760166 SHANK2 -0.25 -6.18 -0.32 1.9e-9 Obesity-related traits; LUSC cis rs7584330 0.652 rs7607231 chr2:238372896 T/C cg14458575 chr2:238380390 NA 0.65 11.29 0.53 2.88e-25 Prostate cancer; LUSC cis rs5769765 1.000 rs764813 chr22:50286172 T/C cg08270630 chr22:50330655 NA -0.4 -6.07 -0.32 3.4e-9 Schizophrenia; LUSC cis rs925550 0.800 rs6837455 chr4:123588942 G/C cg10495464 chr4:123653540 BBS12;LOC729338 -0.6 -5.77 -0.3 1.85e-8 Primary biliary cholangitis; LUSC cis rs80130819 0.688 rs11168455 chr12:48592792 G/A cg24011408 chr12:48396354 COL2A1 0.45 5.82 0.3 1.39e-8 Prostate cancer; LUSC cis rs2857891 0.817 rs2239730 chr11:6977175 G/C cg14883916 chr11:6947541 ZNF215 0.44 5.83 0.3 1.29e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs72901758 0.696 rs72909029 chr17:76249451 A/G cg11439826 chr17:76250004 NA 0.38 5.73 0.3 2.29e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.6 8.66 0.43 2e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1775715 0.737 rs1419171 chr10:32214831 C/A cg03015672 chr10:32216066 ARHGAP12 0.32 5.67 0.3 3.16e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10743315 0.557 rs77299796 chr12:19365100 T/C cg02471346 chr12:19282374 PLEKHA5 0.78 6.28 0.33 1.03e-9 Gut microbiota (bacterial taxa); LUSC cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -9.87 -0.48 2.51e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2806561 0.780 rs12409321 chr1:23398065 C/T cg19743168 chr1:23544995 NA -0.44 -9.14 -0.45 6.38e-18 Height; LUSC cis rs950027 0.620 rs2467862 chr15:45643843 T/G cg26924012 chr15:45694286 SPATA5L1 0.79 12.51 0.56 1.02e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg06641503 chr3:48959341 ARIH2 -0.38 -5.83 -0.3 1.3e-8 Parkinson's disease; LUSC cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg15506890 chr2:3487001 NA -0.57 -9.38 -0.46 1.06e-18 Neurofibrillary tangles; LUSC cis rs59698941 0.943 rs12517073 chr5:132240151 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.31 -0.33 8.76e-10 Apolipoprotein A-IV levels; LUSC cis rs73195822 0.667 rs2339634 chr12:111231277 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.37 0.33 6.43e-10 Itch intensity from mosquito bite; LUSC cis rs9646944 0.501 rs741284 chr2:103083324 G/C cg20060108 chr2:102954350 IL1RL1 0.44 5.87 0.31 1.07e-8 Blood protein levels; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14791831 chr16:28565295 CCDC101 0.44 6.76 0.35 6.29e-11 Asthma; LUSC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7000551 0.689 rs6996872 chr8:22316753 T/C cg12081754 chr8:22256438 SLC39A14 0.45 6.84 0.35 3.9e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.5 7.2 0.37 4.01e-12 Renal function-related traits (BUN); LUSC cis rs11190604 1.000 rs10509744 chr10:102271579 C/T cg07080220 chr10:102295463 HIF1AN 0.68 9.18 0.45 4.75e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs921968 0.643 rs559722 chr2:219398159 A/G cg02176678 chr2:219576539 TTLL4 0.64 11.7 0.54 9.61e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg00343986 chr7:65444356 GUSB 0.47 7.03 0.36 1.14e-11 Aortic root size; LUSC trans rs3857536 0.741 rs4710582 chr6:66939984 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC trans rs9944715 0.859 rs7236687 chr18:43736484 C/G cg01718231 chr17:29326311 RNF135 0.45 6.12 0.32 2.63e-9 Red cell distribution width;Mean corpuscular volume; LUSC trans rs9987353 0.830 rs7010108 chr8:9130674 G/A cg15556689 chr8:8085844 FLJ10661 -0.48 -6.07 -0.32 3.42e-9 Recombination measurement; LUSC cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.66 8.52 0.42 5.41e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs9467711 0.790 rs35162296 chr6:26318262 C/T cg06606381 chr12:133084897 FBRSL1 -0.66 -6.55 -0.34 2.11e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg00631329 chr6:26305371 NA -0.47 -9.41 -0.46 8.03e-19 Educational attainment; LUSC cis rs7927771 0.524 rs11039345 chr11:47720228 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.58 0.34 1.82e-10 Subjective well-being; LUSC cis rs35306767 0.623 rs36051896 chr10:1155747 T/C cg20503657 chr10:835505 NA 0.5 5.81 0.3 1.42e-8 Eosinophil percentage of granulocytes; LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg25767906 chr1:53392781 SCP2 0.61 11.83 0.54 3.29e-27 Monocyte count; LUSC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.03 0.31 4.3e-9 Schizophrenia; LUSC cis rs9287719 0.934 rs6706763 chr2:10751407 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs6546537 1.000 rs12478540 chr2:69844524 C/T cg10773587 chr2:69614142 GFPT1 -0.49 -7.46 -0.38 7.61e-13 Serum thyroid-stimulating hormone levels; LUSC cis rs3736594 0.559 rs1919129 chr2:27818721 C/G cg27432699 chr2:27873401 GPN1 0.63 8.61 0.43 2.91e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7267979 1.000 rs2482941 chr20:25361216 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.57 -0.69 2.11e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6700896 1.000 rs6700896 chr1:66089782 C/T cg04111102 chr1:66153794 NA 0.32 6.96 0.36 1.84e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9815354 0.812 rs61661916 chr3:41921915 T/C cg03022575 chr3:42003672 ULK4 0.83 8.57 0.42 3.85e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs61931739 0.517 rs7313663 chr12:34417058 T/C cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.35e-11 Morning vs. evening chronotype; LUSC cis rs7819412 0.775 rs34094119 chr8:10935898 A/G cg21775007 chr8:11205619 TDH -0.52 -7.47 -0.38 7.16e-13 Triglycerides; LUSC trans rs3857536 0.813 rs1891600 chr6:66941645 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg21724239 chr8:58056113 NA 0.78 9.79 0.47 4.58e-20 Developmental language disorder (linguistic errors); LUSC cis rs1728785 1.000 rs1728764 chr16:68572292 G/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs3785574 0.536 rs2854190 chr17:61960219 G/A cg06873352 chr17:61820015 STRADA 0.54 8.22 0.41 4.53e-15 Height; LUSC cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg26373071 chr5:1325741 CLPTM1L 0.42 7.78 0.39 9.38e-14 Lung cancer; LUSC cis rs9815354 0.812 rs4577439 chr3:41952540 T/A cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg11742103 chr11:62369870 EML3;MTA2 0.55 9.0 0.44 1.77e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7949030 1.000 rs3018561 chr11:62392229 C/A cg22862634 chr11:62369728 EML3;MTA2 -0.49 -7.94 -0.4 3.2e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.66 -9.24 -0.45 3.03e-18 Multiple sclerosis; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg03579872 chr1:53393473 SCP2 -0.39 -5.85 -0.3 1.17e-8 Monocyte count; LUSC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.86e-11 Aortic root size; LUSC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg21984481 chr17:79567631 NPLOC4 -0.54 -10.05 -0.48 5.99e-21 Eye color traits; LUSC cis rs514406 1.000 rs514406 chr1:53330458 A/G cg08736216 chr1:53307985 ZYG11A -0.29 -5.83 -0.3 1.33e-8 Monocyte count; LUSC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg13798780 chr7:105162888 PUS7 0.56 6.07 0.32 3.43e-9 Bipolar disorder (body mass index interaction); LUSC cis rs3768617 0.565 rs4233194 chr1:183060917 G/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.78 0.51 1.83e-23 Fuchs's corneal dystrophy; LUSC cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.09 0.32 3.05e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg21573476 chr21:45109991 RRP1B -0.37 -5.96 -0.31 6.34e-9 Mean corpuscular volume; LUSC cis rs9462027 0.606 rs2814981 chr6:34581055 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.17e-9 Systemic lupus erythematosus; LUSC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.77 8.83 0.43 6.1e-17 Mean platelet volume; LUSC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg06634786 chr22:41940651 POLR3H 0.5 6.02 0.31 4.64e-9 Vitiligo; LUSC cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg23601095 chr6:26197514 HIST1H3D -0.67 -7.25 -0.37 2.94e-12 Gout;Renal underexcretion gout; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg24846343 chr22:24311635 DDTL 0.73 14.86 0.63 1.1e-38 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg08392591 chr16:89556376 ANKRD11 0.52 8.08 0.4 1.22e-14 Multiple myeloma (IgH translocation); LUSC cis rs9517320 0.934 rs9517319 chr13:99125956 T/G cg20487152 chr13:99095054 FARP1 0.34 6.37 0.33 6.33e-10 Longevity; LUSC cis rs11048434 0.761 rs2110191 chr12:9136263 G/A cg13575925 chr12:9217583 LOC144571 0.34 6.35 0.33 7e-10 Sjögren's syndrome; LUSC cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg11244672 chr19:19639970 YJEFN3 -0.47 -6.45 -0.33 3.9e-10 Bipolar disorder; LUSC cis rs2908197 0.806 rs2961047 chr7:75935056 A/G cg10167463 chr7:75959203 YWHAG -0.38 -5.8 -0.3 1.5e-8 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs6087990 0.806 rs992472 chr20:31385269 G/T cg13636640 chr20:31349939 DNMT3B 0.92 19.47 0.73 5.73e-57 Ulcerative colitis; LUSC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.62 -8.05 -0.4 1.49e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg03233332 chr7:66118400 NA -0.43 -6.15 -0.32 2.22e-9 Aortic root size; LUSC cis rs2439831 1.000 rs2467426 chr15:43989518 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.86 9.0 0.44 1.79e-17 Lung cancer in ever smokers; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg13453750 chr1:205783389 SLC41A1 -0.33 -6.51 -0.34 2.83e-10 Menarche (age at onset); LUSC cis rs6681460 0.898 rs536527 chr1:67193793 A/C cg02459107 chr1:67143332 SGIP1 0.47 8.86 0.44 4.67e-17 Presence of antiphospholipid antibodies; LUSC cis rs240764 0.817 rs151573 chr6:101086333 T/C cg09795085 chr6:101329169 ASCC3 0.41 5.99 0.31 5.5e-9 Neuroticism; LUSC cis rs2742417 1.000 rs1969626 chr3:45746836 A/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.48e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9902453 0.765 rs2628191 chr17:28051140 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.32 -0.53 2.22e-25 Coffee consumption (cups per day); LUSC cis rs7937682 0.562 rs10891276 chr11:111370415 A/C cg09085632 chr11:111637200 PPP2R1B -0.48 -6.67 -0.34 1.04e-10 Primary sclerosing cholangitis; LUSC trans rs1941687 0.509 rs7238029 chr18:31317755 A/G cg27147174 chr7:100797783 AP1S1 -0.52 -8.23 -0.41 4.24e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs4925386 0.959 rs4925385 chr20:60920624 A/G cg24112000 chr20:60950667 NA 0.36 6.8 0.35 4.72e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs2625529 0.824 rs2415130 chr15:72242554 G/A cg16672083 chr15:72433130 SENP8 -0.5 -7.47 -0.38 7.18e-13 Red blood cell count; LUSC cis rs3806843 0.933 rs10069930 chr5:140163328 T/A cg26395211 chr5:140044315 WDR55 -0.38 -5.84 -0.3 1.25e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 6.01 0.31 4.91e-9 Rheumatoid arthritis; LUSC cis rs314370 0.855 rs17883557 chr7:100494949 G/T cg08558340 chr7:100472263 SRRT 0.51 6.27 0.32 1.11e-9 Resting heart rate; LUSC cis rs4144743 0.759 rs1009312 chr17:45332140 G/A cg18085866 chr17:45331354 ITGB3 -0.75 -7.81 -0.39 7.38e-14 Body mass index; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg05872129 chr22:39784769 NA 0.62 11.7 0.54 1.01e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11644478 chr21:40555479 PSMG1 0.94 18.56 0.71 2.36e-53 Cognitive function; LUSC cis rs9399401 0.845 rs263183 chr6:142862181 C/T cg03128060 chr6:142623767 GPR126 0.33 6.16 0.32 2.14e-9 Chronic obstructive pulmonary disease; LUSC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg12963246 chr6:28129442 ZNF389 -0.52 -7.43 -0.38 9.41e-13 Depression; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg19853413 chr5:135468610 SMAD5;SMAD5OS 0.43 6.18 0.32 1.88e-9 Mosquito bite size; LUSC trans rs61931739 0.534 rs11053072 chr12:34202399 A/C cg26384229 chr12:38710491 ALG10B 0.74 12.08 0.55 4.07e-28 Morning vs. evening chronotype; LUSC cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg23711669 chr6:146136114 FBXO30 0.82 14.57 0.62 1.5e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC cis rs3925075 0.934 rs9673522 chr16:31347648 T/C cg02846316 chr16:31340340 ITGAM 0.36 6.66 0.34 1.11e-10 IgA nephropathy; LUSC cis rs7552167 1.000 rs59960858 chr1:24519437 C/A cg01960748 chr1:24522592 NA 0.63 8.92 0.44 3.07e-17 Psoriasis vulgaris; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg00166722 chr3:10149974 C3orf24 0.61 7.9 0.4 3.96e-14 Alzheimer's disease; LUSC cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg24692254 chr21:30365293 RNF160 0.91 18.54 0.71 2.79e-53 Dental caries; LUSC cis rs7267979 1.000 rs1046073 chr20:25281333 G/A cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8044868 0.586 rs7199261 chr16:72082788 A/G cg16579770 chr16:72058938 DHODH 0.34 5.77 0.3 1.86e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg00166722 chr3:10149974 C3orf24 0.56 7.54 0.38 4.61e-13 Alzheimer's disease; LUSC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg00750074 chr16:89608354 SPG7 -0.48 -8.12 -0.41 9.4e-15 Multiple myeloma (IgH translocation); LUSC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg12927641 chr6:109611667 NA -0.36 -6.12 -0.32 2.69e-9 Reticulocyte fraction of red cells; LUSC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg11764359 chr7:65958608 NA 0.7 10.74 0.51 2.63e-23 Aortic root size; LUSC cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg03146154 chr1:46216737 IPP -0.48 -7.13 -0.36 6.25e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg15556689 chr8:8085844 FLJ10661 0.69 11.73 0.54 7.82e-27 Mood instability; LUSC cis rs4144743 0.759 rs4289057 chr17:45321030 G/A cg18085866 chr17:45331354 ITGB3 -0.83 -8.12 -0.41 9.07e-15 Body mass index; LUSC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg05861140 chr6:150128134 PCMT1 -0.44 -7.14 -0.36 5.87e-12 Lung cancer; LUSC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg03354898 chr7:1950403 MAD1L1 -0.37 -7.09 -0.36 8.22e-12 Schizophrenia; LUSC cis rs7582180 0.739 rs10195793 chr2:100925803 A/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.46 -0.42 8.2e-16 Intelligence (multi-trait analysis); LUSC cis rs936229 0.861 rs7180484 chr15:75115416 G/T cg14664628 chr15:75095509 CSK 1.0 17.44 0.69 7.17e-49 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC trans rs12439619 0.508 rs17354842 chr15:82469600 G/T cg04831495 chr15:85060580 GOLGA6L5 0.44 6.83 0.35 4.02e-11 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00767644 chr1:174968745 CACYBP 0.4 6.11 0.32 2.73e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.18 0.55 1.74e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg11578532 chr1:161008127 TSTD1 0.35 7.29 0.37 2.28e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs877282 0.583 rs7072970 chr10:822757 G/A cg13775593 chr10:823151 NA 0.31 6.1 0.32 2.96e-9 Uric acid levels; LUSC cis rs854765 0.663 rs12941550 chr17:17753828 C/A cg09796270 chr17:17721594 SREBF1 -0.46 -8.29 -0.41 2.85e-15 Total body bone mineral density; LUSC cis rs3125734 0.633 rs4979754 chr10:64048959 G/A cg09941381 chr10:64027924 RTKN2 -0.4 -7.19 -0.37 4.18e-12 Rheumatoid arthritis; LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.6 0.34 1.59e-10 Menopause (age at onset); LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.25 -0.32 1.22e-9 Developmental language disorder (linguistic errors); LUSC cis rs2652834 1.000 rs2729780 chr15:63404639 C/G cg05507819 chr15:63340323 TPM1 0.67 8.16 0.41 7.01e-15 HDL cholesterol; LUSC trans rs853679 0.607 rs13204012 chr6:28201531 G/A cg06606381 chr12:133084897 FBRSL1 -1.08 -9.49 -0.46 4.57e-19 Depression; LUSC cis rs2029213 0.523 rs3773739 chr3:53268429 A/G cg16894138 chr3:53270350 TKT -0.33 -7.0 -0.36 1.4e-11 Heart rate; LUSC cis rs9393777 0.720 rs36022097 chr6:26995168 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -5.82 -0.3 1.35e-8 Intelligence (multi-trait analysis); LUSC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg07395648 chr5:131743802 NA -0.44 -7.04 -0.36 1.07e-11 Breast cancer;Mosquito bite size; LUSC cis rs870825 0.929 rs72689261 chr4:185590897 C/A cg04058563 chr4:185651563 MLF1IP 0.83 11.29 0.53 2.87e-25 Blood protein levels; LUSC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg26380479 chr7:97908229 NA 0.26 5.77 0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs5769707 0.632 rs135877 chr22:50014002 A/G cg20744362 chr22:50050164 C22orf34 0.39 7.19 0.37 4.38e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.74 0.35 6.95e-11 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.500 rs11524949 chr12:34435551 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.69 0.5 4.02e-23 Morning vs. evening chronotype; LUSC cis rs11779988 0.545 rs397096 chr8:17798848 C/G cg01800426 chr8:17659068 MTUS1 0.52 6.31 0.33 8.63e-10 Breast cancer; LUSC cis rs6845621 0.901 rs2159971 chr4:18917125 A/T cg12196642 chr4:18937545 NA -0.34 -6.44 -0.33 4.14e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg03060546 chr3:49711283 APEH 0.66 7.33 0.37 1.74e-12 Menarche (age at onset); LUSC cis rs1372520 0.684 rs3113355 chr4:90745345 A/T cg15133208 chr4:90757351 SNCA -0.53 -8.22 -0.41 4.69e-15 Neuroticism; LUSC cis rs10089 0.953 rs2190797 chr5:127352875 C/A cg19767477 chr5:127420684 SLC12A2 -0.41 -5.83 -0.3 1.28e-8 Ileal carcinoids; LUSC cis rs11785693 0.862 rs11774842 chr8:4979769 A/C cg26367366 chr8:4980734 NA 0.78 9.28 0.45 2.24e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg16325326 chr1:53192061 ZYG11B 0.81 12.61 0.57 4.39e-30 Monocyte count; LUSC cis rs1595825 0.891 rs59617443 chr2:198653204 C/A cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 5.92e-9 Ulcerative colitis; LUSC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg17366294 chr4:99064904 C4orf37 0.52 9.54 0.46 3.05e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg20476274 chr7:133979776 SLC35B4 0.78 13.04 0.58 1.1e-31 Mean platelet volume; LUSC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg00033643 chr7:134001901 SLC35B4 0.47 7.33 0.37 1.7e-12 Mean platelet volume; LUSC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg12463550 chr7:65579703 CRCP -0.51 -7.39 -0.38 1.16e-12 Aortic root size; LUSC cis rs11997175 0.766 rs56803376 chr8:33687676 T/C ch.8.33884649F chr8:33765107 NA 0.39 6.1 0.32 3e-9 Body mass index; LUSC cis rs56399783 0.901 rs79932907 chr7:2827901 C/G cg14895029 chr7:2775587 GNA12 0.5 6.14 0.32 2.4e-9 Childhood ear infection; LUSC cis rs11122272 0.735 rs2790873 chr1:231539685 A/G cg06096015 chr1:231504339 EGLN1 0.55 9.62 0.47 1.75e-19 Hemoglobin concentration; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg06671660 chr6:41068741 NFYA;LOC221442 -0.39 -5.67 -0.3 3.08e-8 Alzheimer's disease (late onset); LUSC cis rs6121246 0.529 rs750144 chr20:30179027 C/T cg13852791 chr20:30311386 BCL2L1 -0.71 -8.03 -0.4 1.73e-14 Mean corpuscular hemoglobin; LUSC cis rs34779708 0.931 rs1926556 chr10:35344907 T/C cg03585969 chr10:35415529 CREM 0.58 8.43 0.42 1.02e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg11766577 chr21:47581405 C21orf56 0.56 8.77 0.43 9.59e-17 Testicular germ cell tumor; LUSC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg21132104 chr15:45694354 SPATA5L1 0.54 7.3 0.37 2.09e-12 Homoarginine levels; LUSC trans rs1171606 0.731 rs1171650 chr10:61450153 C/T cg14119616 chr11:17099403 RPS13 -0.41 -6.16 -0.32 2.1e-9 Acylcarnitine levels; LUSC cis rs6733011 0.581 rs4851162 chr2:99466659 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.71 -0.34 8.42e-11 Bipolar disorder; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg07507251 chr3:52567010 NT5DC2 0.31 6.25 0.32 1.26e-9 Bipolar disorder; LUSC cis rs6665290 0.935 rs12403236 chr1:227196502 C/G cg10327440 chr1:227177885 CDC42BPA -1.22 -39.76 -0.91 1.1e-128 Myeloid white cell count; LUSC cis rs17826219 0.568 rs11658027 chr17:29094882 A/G cg13385521 chr17:29058706 SUZ12P -0.68 -6.94 -0.36 1.99e-11 Body mass index; LUSC cis rs10931896 0.531 rs295118 chr2:201144004 C/T cg23649088 chr2:200775458 C2orf69 0.45 6.95 0.36 1.92e-11 Systolic blood pressure; LUSC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg06634786 chr22:41940651 POLR3H -0.54 -6.33 -0.33 7.84e-10 Vitiligo; LUSC cis rs1953600 0.645 rs2819950 chr10:81935279 G/A cg00277334 chr10:82204260 NA 0.5 7.98 0.4 2.36e-14 Sarcoidosis; LUSC cis rs7582180 0.627 rs4149523 chr2:101007039 T/C cg12002119 chr2:101014098 CHST10 0.37 6.19 0.32 1.72e-9 Intelligence (multi-trait analysis); LUSC cis rs7043114 0.507 rs10820971 chr9:95161740 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.63 -0.34 1.36e-10 Height; LUSC cis rs2540226 0.550 rs2160198 chr2:39930224 A/G cg23576258 chr2:39999331 THUMPD2 0.37 6.3 0.33 9.56e-10 Personality dimensions; LUSC cis rs1577917 0.682 rs6935918 chr6:86283575 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 7.43 0.38 9.21e-13 Response to antipsychotic treatment; LUSC cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg01973587 chr1:228161476 NA 0.47 8.54 0.42 4.76e-16 Diastolic blood pressure; LUSC cis rs8072100 0.701 rs4794053 chr17:45769551 G/A cg08085267 chr17:45401833 C17orf57 -0.46 -6.71 -0.34 8.46e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9790314 0.934 rs9290074 chr3:160997823 T/C cg04691961 chr3:161091175 C3orf57 -0.34 -5.78 -0.3 1.73e-8 Morning vs. evening chronotype; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg24846343 chr22:24311635 DDTL 0.76 16.98 0.68 4.84e-47 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7129220 0.858 rs2957657 chr11:10287810 A/G cg06252276 chr11:34852392 NA -0.53 -6.07 -0.32 3.53e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg15103426 chr22:29168792 CCDC117 -0.44 -5.76 -0.3 1.96e-8 Lymphocyte counts; LUSC cis rs977987 0.806 rs1030262 chr16:75491327 C/A cg03315344 chr16:75512273 CHST6 0.49 9.36 0.46 1.19e-18 Dupuytren's disease; LUSC cis rs2404602 0.692 rs35498563 chr15:76958868 C/T cg22467129 chr15:76604101 ETFA -0.43 -6.85 -0.35 3.46e-11 Blood metabolite levels; LUSC cis rs1577917 0.655 rs2758849 chr6:86344296 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -7.23 -0.37 3.3e-12 Response to antipsychotic treatment; LUSC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg17264618 chr3:40429014 ENTPD3 -0.33 -7.25 -0.37 2.9e-12 Renal cell carcinoma; LUSC cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.13 0.48 3.23e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2439831 0.702 rs16977724 chr15:44151299 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.71 0.34 8.14e-11 Lung cancer in ever smokers; LUSC cis rs983392 0.805 rs1834550 chr11:59959843 T/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.77 -0.3 1.82e-8 Alzheimer's disease (late onset); LUSC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg23172400 chr8:95962367 TP53INP1 -0.31 -5.88 -0.31 9.97e-9 Type 2 diabetes; LUSC cis rs62400317 0.859 rs6920046 chr6:45159431 A/C cg18551225 chr6:44695536 NA -0.45 -7.22 -0.37 3.47e-12 Total body bone mineral density; LUSC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs4631830 0.863 rs7081532 chr10:51526093 A/G cg16070123 chr10:51489643 NA -0.5 -8.06 -0.4 1.4e-14 Prostate-specific antigen levels; LUSC trans rs1486139 0.967 rs2010427 chr7:46283836 A/G cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs7043114 0.563 rs10820990 chr9:95323297 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.35 6.41 0.33 4.99e-10 Height; LUSC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg18827107 chr12:86230957 RASSF9 -0.39 -5.69 -0.3 2.76e-8 Major depressive disorder; LUSC cis rs9646944 0.501 rs1403552 chr2:103088777 C/T cg20060108 chr2:102954350 IL1RL1 0.45 5.97 0.31 6.13e-9 Blood protein levels; LUSC cis rs1754541 0.517 rs514793 chr1:101604554 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.56 -5.89 -0.31 9.46e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes;Sum eosinophil basophil counts; LUSC cis rs6845621 0.835 rs11728202 chr4:18937351 G/T cg12196642 chr4:18937545 NA -0.36 -6.76 -0.35 6.33e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -9.15 -0.45 5.94e-18 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg22166914 chr1:53195759 ZYG11B 0.57 9.28 0.45 2.22e-18 Monocyte count; LUSC cis rs478304 0.934 rs669742 chr11:65501291 C/T cg05805236 chr11:65401703 PCNXL3 0.4 6.82 0.35 4.28e-11 Acne (severe); LUSC cis rs9902453 0.904 rs8078638 chr17:28290358 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.51 0.5 1.61e-22 Coffee consumption (cups per day); LUSC cis rs4631830 0.720 rs11599333 chr10:51499655 A/C cg16070123 chr10:51489643 NA 0.57 9.36 0.46 1.24e-18 Prostate-specific antigen levels; LUSC cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg18099408 chr3:52552593 STAB1 0.35 5.71 0.3 2.46e-8 Body mass index; LUSC cis rs2395909 1 rs2395909 chr7:107292663 G/A cg23024343 chr7:107201750 COG5 0.4 6.08 0.32 3.36e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.63e-8 Depression; LUSC cis rs7940866 0.804 rs3910266 chr11:130814272 A/C cg12179176 chr11:130786555 SNX19 0.65 9.69 0.47 9.71e-20 Schizophrenia; LUSC cis rs11971779 0.553 rs10228643 chr7:139115420 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs2820315 0.867 rs2820318 chr1:201878620 T/C cg10061532 chr1:201886748 LMOD1 0.28 6.45 0.33 3.87e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs10191773 0.589 rs72831636 chr2:112948248 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.74 7.65 0.39 2.11e-13 Yeast infection; LUSC cis rs1507153 0.549 rs699183 chr6:79336011 A/G cg05283184 chr6:79620031 NA -0.39 -7.15 -0.36 5.61e-12 Sjögren's syndrome; LUSC cis rs59918340 0.764 rs2304282 chr8:142229543 A/G cg23750338 chr8:142222470 SLC45A4 0.58 11.04 0.52 2.3e-24 Immature fraction of reticulocytes; LUSC cis rs911555 0.723 rs12894652 chr14:103926024 A/G cg12935359 chr14:103987150 CKB 0.66 10.71 0.51 3.27e-23 Intelligence (multi-trait analysis); LUSC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.44 -0.38 8.8e-13 Height; LUSC cis rs9325144 0.555 rs4882359 chr12:38726679 T/C cg26384229 chr12:38710491 ALG10B 0.6 9.49 0.46 4.46e-19 Morning vs. evening chronotype; LUSC cis rs11209002 0.567 rs2815385 chr1:67542083 A/G cg02640540 chr1:67518911 SLC35D1 0.6 8.15 0.41 7.39e-15 Crohn's disease; LUSC cis rs7179456 0.547 rs653765 chr15:59042012 T/C cg05156742 chr15:59063176 FAM63B 0.52 7.73 0.39 1.31e-13 Asperger disorder; LUSC cis rs4363385 0.934 rs1415964 chr1:152955085 T/C cg00922841 chr1:152955080 SPRR1A -0.49 -8.26 -0.41 3.39e-15 Inflammatory skin disease; LUSC cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg00012203 chr2:219082015 ARPC2 0.84 15.37 0.64 1.07e-40 Colorectal cancer; LUSC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -7.88 -0.4 4.51e-14 Chronic sinus infection; LUSC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg07701084 chr6:150067640 NUP43 0.53 7.99 0.4 2.25e-14 Lung cancer; LUSC cis rs4803468 1.000 rs2241706 chr19:41912807 A/G cg09537434 chr19:41945824 ATP5SL -0.9 -15.71 -0.65 4.81e-42 Height; LUSC cis rs9660992 0.624 rs72745217 chr1:205261482 C/G cg21545522 chr1:205238299 TMCC2 0.5 9.45 0.46 5.97e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12893668 0.703 rs2403197 chr14:104053764 C/T cg08213375 chr14:104286397 PPP1R13B 0.35 5.78 0.3 1.74e-8 Reticulocyte count; LUSC cis rs28735056 0.563 rs55642704 chr18:77688124 C/T cg20368463 chr18:77673604 PQLC1 -0.68 -10.48 -0.5 2.03e-22 Schizophrenia; LUSC cis rs6693567 0.545 rs1260391 chr1:150373077 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.16 0.36 5.09e-12 Migraine; LUSC cis rs8017423 0.967 rs2401875 chr14:90688451 A/G cg04374321 chr14:90722782 PSMC1 0.72 11.41 0.53 1.14e-25 Mortality in heart failure; LUSC cis rs12530845 0.832 rs56306315 chr7:135329107 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs6547741 1.000 rs1528402 chr2:27857517 G/A cg12559939 chr2:27858050 GPN1 0.41 6.33 0.33 8.01e-10 Oral cavity cancer; LUSC trans rs1908814 0.503 rs34657250 chr8:11795373 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.24 -0.41 4.09e-15 Neuroticism; LUSC cis rs12681288 0.550 rs4637864 chr8:959761 C/T cg15309053 chr8:964076 NA 0.42 8.73 0.43 1.22e-16 Schizophrenia; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg00024416 chr22:24240387 NA -0.35 -6.08 -0.32 3.23e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11155671 0.530 rs7768626 chr6:150207962 G/T cg04369109 chr6:150039330 LATS1 -0.4 -5.78 -0.3 1.67e-8 Testicular germ cell tumor; LUSC cis rs7267979 0.546 rs8115804 chr20:25438783 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.74 -13.06 -0.58 9.11e-32 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6499188 0.571 rs1645975 chr16:68564448 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9650657 0.504 rs10109167 chr8:11033525 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.09 -0.32 3.11e-9 Neuroticism; LUSC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg08493051 chr2:3487164 NA -0.55 -8.5 -0.42 6.19e-16 Neurofibrillary tangles; LUSC cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.51 7.59e-24 Schizophrenia; LUSC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg04362960 chr10:104952993 NT5C2 0.57 8.99 0.44 1.92e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27051171 chr2:7005923 CMPK2 -0.46 -5.96 -0.31 6.39e-9 Bipolar disorder and schizophrenia; LUSC trans rs867371 0.519 rs1566560 chr15:82524457 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.38 -6.33 -0.33 7.96e-10 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs72960926 0.590 rs117275111 chr6:74750921 G/A cg03266952 chr6:74778945 NA -0.82 -6.15 -0.32 2.24e-9 Metabolite levels (MHPG); LUSC cis rs9921338 0.961 rs66555362 chr16:11388833 G/T cg00044050 chr16:11439710 C16orf75 -0.5 -6.99 -0.36 1.52e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs3540 0.597 rs1978150 chr15:91037041 A/G cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.84 -0.3 1.22e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg05022225 chr19:49866942 DKKL1;TEAD2 -0.51 -6.27 -0.32 1.09e-9 Multiple sclerosis; LUSC cis rs9443645 0.527 rs10943608 chr6:79674929 T/C cg05283184 chr6:79620031 NA -0.46 -8.84 -0.44 5.56e-17 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg01879757 chr17:41196368 BRCA1 -0.4 -6.01 -0.31 4.86e-9 Menopause (age at onset); LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 16.51 0.67 3.47e-45 Gut microbiome composition (summer); LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg19266014 chr7:2183958 MAD1L1 -0.34 -5.78 -0.3 1.75e-8 Bipolar disorder and schizophrenia; LUSC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg00376283 chr12:123451042 ABCB9 0.8 12.79 0.57 9.44e-31 Platelet count; LUSC trans rs17607347 0.542 rs62052911 chr16:72567301 G/T cg12945194 chr11:64703312 GPHA2 0.38 6.06 0.31 3.74e-9 Intelligence (multi-trait analysis); LUSC cis rs868036 1.000 rs868036 chr15:68055013 T/A cg05925327 chr15:68127851 NA 0.33 5.86 0.31 1.12e-8 Restless legs syndrome; LUSC trans rs7615952 0.512 rs4646765 chr3:125820707 G/A cg07211511 chr3:129823064 LOC729375 -0.75 -9.67 -0.47 1.2e-19 Blood pressure (smoking interaction); LUSC cis rs1395 0.744 rs62130714 chr2:27532870 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 6.07 0.32 3.38e-9 Blood metabolite levels; LUSC cis rs34779708 0.966 rs1148245 chr10:35511894 C/T cg04310649 chr10:35416472 CREM -0.37 -5.68 -0.3 2.96e-8 Inflammatory bowel disease;Crohn's disease; LUSC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg23590916 chr17:43697445 MGC57346 0.49 6.63 0.34 1.38e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg04450456 chr4:17643702 FAM184B 0.38 6.28 0.33 1.03e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7312933 0.558 rs55702525 chr12:42814309 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.83 -0.35 4.12e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6815814 0.950 rs55830619 chr4:38807364 G/A cg02016764 chr4:38805732 TLR1 -0.54 -5.75 -0.3 2.06e-8 Breast cancer; LUSC cis rs7208859 0.623 rs56325146 chr17:29151024 T/C cg13385521 chr17:29058706 SUZ12P 0.59 5.81 0.3 1.49e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.42e-19 Prudent dietary pattern; LUSC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg26116260 chr4:7069785 GRPEL1 -1.12 -16.47 -0.67 5.1e-45 Monocyte percentage of white cells; LUSC cis rs2295359 1.000 rs10889664 chr1:67635475 C/T cg12940439 chr1:67600707 NA 0.35 5.86 0.31 1.12e-8 Psoriasis; LUSC trans rs6502050 0.835 rs12950475 chr17:80118924 T/C cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs4969178 0.560 rs4969182 chr17:76393030 T/C cg05887092 chr17:76393375 PGS1 0.65 12.68 0.57 2.45e-30 HDL cholesterol levels; LUSC trans rs9291683 0.509 rs6849717 chr4:9958719 T/C cg26043149 chr18:55253948 FECH -0.45 -7.03 -0.36 1.18e-11 Bone mineral density; LUSC cis rs6500395 0.962 rs9936883 chr16:48676443 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.86e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs8133932 0.608 rs413246 chr21:47346066 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.8 -0.3 1.54e-8 Schizophrenia; LUSC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.03 0.31 4.3e-9 Schizophrenia; LUSC cis rs6087990 1.000 rs1007124 chr20:31345752 G/C cg13636640 chr20:31349939 DNMT3B 1.03 23.38 0.79 2.6e-72 Ulcerative colitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22996605 chr6:43138883 SRF 0.44 6.4 0.33 5.16e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5771069 0.931 rs137864 chr22:50446988 C/T cg27068297 chr22:50451975 IL17REL 0.29 5.97 0.31 5.98e-9 Ulcerative colitis; LUSC cis rs9640161 0.830 rs35635199 chr7:150063342 C/T cg21361702 chr7:150065534 REPIN1 0.58 8.25 0.41 3.58e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC trans rs8073060 0.586 rs2523114 chr17:34023762 G/A cg19694781 chr19:47549865 TMEM160 -1.13 -17.98 -0.7 4.92e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs62400317 0.821 rs12206568 chr6:45152747 C/T cg20913747 chr6:44695427 NA -0.47 -7.49 -0.38 6.14e-13 Total body bone mineral density; LUSC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg10909506 chr17:38081995 ORMDL3 0.34 6.01 0.31 4.74e-9 Self-reported allergy; LUSC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg11812906 chr14:75593930 NEK9 -0.64 -10.99 -0.52 3.49e-24 Height; LUSC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg24399712 chr22:39784796 NA -0.62 -11.12 -0.52 1.19e-24 Intelligence (multi-trait analysis); LUSC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg02574844 chr11:5959923 NA -0.41 -6.39 -0.33 5.65e-10 DNA methylation (variation); LUSC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg02221750 chr19:17393354 ANKLE1 -0.9 -14.05 -0.61 1.47e-35 Systemic lupus erythematosus; LUSC cis rs4363385 0.693 rs10788849 chr1:152902240 C/A cg00922841 chr1:152955080 SPRR1A -0.4 -6.55 -0.34 2.16e-10 Inflammatory skin disease; LUSC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4792901 0.802 rs9894910 chr17:41574306 T/A cg22562494 chr17:41607896 ETV4 -0.33 -6.18 -0.32 1.9e-9 Dupuytren's disease; LUSC cis rs9303401 0.527 rs34835800 chr17:56764990 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.66 0.57 2.81e-30 Cognitive test performance; LUSC cis rs34779708 0.931 rs72789609 chr10:35306206 C/T cg03585969 chr10:35415529 CREM 0.6 8.66 0.43 2.08e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.5 0.56 1.14e-29 Motion sickness; LUSC cis rs735396 1.000 rs735396 chr12:121438844 T/C cg02403541 chr12:121454288 C12orf43 0.6 8.66 0.43 2.08e-16 N-glycan levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02013961 chr6:142468197 VTA1 -0.41 -6.09 -0.32 3.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8114671 0.562 rs4911164 chr20:33479488 G/C cg08999081 chr20:33150536 PIGU 0.32 5.66 0.3 3.32e-8 Height; LUSC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg23758822 chr17:41437982 NA 1.05 20.45 0.75 7.54e-61 Menopause (age at onset); LUSC cis rs79911532 0.515 rs10245109 chr7:75846115 G/T cg03592824 chr7:75666768 STYXL1 0.59 6.02 0.31 4.62e-9 Mononucleosis; LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg03790207 chr6:42947109 PEX6 -0.45 -6.76 -0.35 6.08e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4595586 0.545 rs12827823 chr12:39392144 G/T cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg00701064 chr4:6280414 WFS1 0.59 14.24 0.61 2.82e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg10909506 chr17:38081995 ORMDL3 0.35 6.22 0.32 1.45e-9 Self-reported allergy; LUSC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg03233332 chr7:66118400 NA -0.41 -6.07 -0.32 3.5e-9 Aortic root size; LUSC cis rs17373728 0.585 rs1912709 chr8:76178563 C/T cg07016329 chr8:76221503 NA 0.48 6.43 0.33 4.45e-10 Diabetic kidney disease; LUSC trans rs57221529 0.766 rs4081847 chr5:574072 C/T cg25482853 chr8:67687455 SGK3 1.15 16.65 0.67 9.36e-46 Lung disease severity in cystic fibrosis; LUSC cis rs3741404 0.574 rs616563 chr11:63877501 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.8 12.78 0.57 1.04e-30 Platelet count; LUSC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg05425664 chr17:57184151 TRIM37 -0.56 -8.31 -0.41 2.44e-15 Intelligence (multi-trait analysis); LUSC cis rs1728785 0.901 rs11075687 chr16:68655894 T/C cg02972257 chr16:68554789 NA -0.53 -6.52 -0.34 2.6200000000000003e-10 Ulcerative colitis; LUSC cis rs1950626 0.833 rs2400963 chr14:101395706 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.41 7.33 0.37 1.78e-12 Pelvic organ prolapse (moderate/severe); LUSC cis rs6121246 0.909 rs6060960 chr20:30394517 G/T cg13852791 chr20:30311386 BCL2L1 -0.77 -10.81 -0.51 1.51e-23 Mean corpuscular hemoglobin; LUSC cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg17143192 chr8:8559678 CLDN23 0.64 9.14 0.45 6.38e-18 Obesity-related traits; LUSC cis rs6543140 0.964 rs6543142 chr2:103082006 T/C cg09003973 chr2:102972529 NA 0.54 6.84 0.35 3.74e-11 Blood protein levels; LUSC cis rs6500602 0.929 rs9926114 chr16:4478322 C/G cg08645402 chr16:4508243 NA 0.54 8.91 0.44 3.31e-17 Schizophrenia; LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.78 0.3 1.72e-8 Menopause (age at onset); LUSC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg09699651 chr6:150184138 LRP11 0.38 5.86 0.31 1.13e-8 Lung cancer; LUSC cis rs12999616 0.857 rs34459720 chr2:98325447 T/C cg26665480 chr2:98280029 ACTR1B 0.51 5.88 0.31 9.81e-9 Colorectal cancer; LUSC cis rs11148252 0.574 rs2038826 chr13:53280013 G/A cg02158880 chr13:53174818 NA 0.58 9.85 0.47 2.84e-20 Lewy body disease; LUSC cis rs6687430 0.526 rs7555790 chr1:10613167 A/G cg17425144 chr1:10567563 PEX14 -0.62 -12.05 -0.55 5.4e-28 Hand grip strength; LUSC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg15557168 chr22:42548783 NA -0.45 -6.88 -0.35 2.98e-11 Schizophrenia; LUSC cis rs11250464 0.794 rs11250487 chr10:1434168 C/A cg08668359 chr10:1443807 ADARB2 0.42 6.32 0.33 8.16e-10 Radiation response; LUSC cis rs7945705 0.846 rs905290 chr11:8753729 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.53 9.98 0.48 1.04e-20 Hemoglobin concentration; LUSC cis rs6546537 0.868 rs62133967 chr2:69891708 G/C cg10773587 chr2:69614142 GFPT1 -0.53 -8.12 -0.41 9.2e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs76662990 0.764 rs77704408 chr5:73884165 G/A cg01264639 chr5:73839484 NA 0.55 5.77 0.3 1.78e-8 Residual cognition; LUSC cis rs7523050 0.643 rs34801874 chr1:109404382 C/T cg08274380 chr1:109419600 GPSM2 1.07 10.65 0.5 5.34e-23 Fat distribution (HIV); LUSC cis rs17095355 0.892 rs7085888 chr10:111713930 A/G cg00817464 chr10:111662876 XPNPEP1 0.52 6.55 0.34 2.16e-10 Biliary atresia; LUSC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg03433033 chr1:76189801 ACADM 0.82 14.21 0.61 3.48e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg16049864 chr8:95962084 TP53INP1 -0.43 -7.19 -0.37 4.36e-12 Type 2 diabetes; LUSC cis rs7107174 1.000 rs10899465 chr11:78013588 G/A cg02023728 chr11:77925099 USP35 0.49 6.88 0.35 3.02e-11 Testicular germ cell tumor; LUSC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg21782813 chr7:2030301 MAD1L1 -0.56 -9.78 -0.47 5.07e-20 Bipolar disorder and schizophrenia; LUSC cis rs6840360 0.615 rs9884167 chr4:152470799 A/G cg22705602 chr4:152727874 NA -0.32 -6.41 -0.33 5.07e-10 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14074924 chr1:1167315 SDF4;B3GALT6 0.46 6.53 0.34 2.5e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg11645453 chr3:52864694 ITIH4 0.59 14.12 0.61 8.31e-36 Schizophrenia; LUSC cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC cis rs2197308 0.765 rs68029712 chr12:37906585 T/G cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs9462027 0.628 rs2814971 chr6:34714209 A/T cg07306190 chr6:34760872 UHRF1BP1 0.34 5.87 0.31 1.07e-8 Systemic lupus erythematosus; LUSC cis rs1832871 0.965 rs1832872 chr6:158721813 G/A cg07165851 chr6:158734300 TULP4 -0.37 -6.57 -0.34 1.93e-10 Height; LUSC cis rs4499344 0.589 rs259233 chr19:33127000 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.98 14.42 0.62 5.52e-37 Mean platelet volume; LUSC cis rs7582180 0.591 rs1030902 chr2:101007178 T/G cg12002119 chr2:101014098 CHST10 0.37 6.27 0.32 1.12e-9 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs950169 0.650 rs12902052 chr15:85125838 A/T cg17507749 chr15:85114479 UBE2QP1 0.69 8.87 0.44 4.5e-17 Schizophrenia; LUSC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs3126085 0.935 rs4845431 chr1:152227977 A/G cg26876637 chr1:152193138 HRNR 0.44 6.42 0.33 4.8e-10 Atopic dermatitis; LUSC cis rs10193935 0.901 rs9309082 chr2:42581412 A/G cg27598129 chr2:42591480 NA -0.64 -8.42 -0.42 1.15e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.89 0.48 2.11e-20 Bipolar disorder; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg11494091 chr17:61959527 GH2 0.63 13.47 0.59 2.57e-33 Prudent dietary pattern; LUSC cis rs9470366 0.509 rs4714001 chr6:36638175 G/A cg08179530 chr6:36648295 CDKN1A -0.47 -6.7 -0.34 8.94e-11 QRS duration; LUSC cis rs4499344 0.556 rs259231 chr19:33129067 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.97 14.29 0.62 1.76e-36 Mean platelet volume; LUSC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -5.76 -0.3 1.87e-8 Developmental language disorder (linguistic errors); LUSC cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.69 0.3 2.81e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9469578 0.579 rs7744811 chr6:33692368 T/C cg18708504 chr6:33715942 IP6K3 0.67 6.69 0.34 9.52e-11 Phosphorus levels; LUSC cis rs7561273 0.586 rs11902756 chr2:24300932 A/G cg20701182 chr2:24300061 SF3B14 0.51 6.57 0.34 1.98e-10 Quantitative traits; LUSC cis rs1908814 0.516 rs58869268 chr8:11797095 G/C cg00262122 chr8:11665843 FDFT1 0.39 5.82 0.3 1.37e-8 Neuroticism; LUSC cis rs7804356 1.000 rs28733208 chr7:26830825 G/A cg03456212 chr7:26904342 SKAP2 -0.56 -6.62 -0.34 1.47e-10 Type 1 diabetes; LUSC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.6 0.38 3.08e-13 Bipolar disorder; LUSC cis rs6456156 0.524 rs6934043 chr6:167466449 C/T cg25258033 chr6:167368657 RNASET2 0.36 5.68 0.3 2.88e-8 Primary biliary cholangitis; LUSC cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.43 -6.37 -0.33 6.19e-10 Schizophrenia; LUSC cis rs4363385 0.818 rs3795381 chr1:153004848 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.46e-8 Inflammatory skin disease; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.47 -6.39 -0.33 5.54e-10 Renal function-related traits (BUN); LUSC cis rs4901869 0.902 rs10149194 chr14:59308198 A/G cg02291164 chr14:59296302 NA -0.59 -11.64 -0.54 1.6e-26 Panic disorder; LUSC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10492096 0.853 rs7300092 chr12:6607364 T/C cg13857086 chr12:6580257 VAMP1 0.59 6.98 0.36 1.57e-11 Hip geometry; LUSC cis rs10871290 0.650 rs2288054 chr16:74491733 A/G cg01733217 chr16:74700730 RFWD3 0.71 10.46 0.5 2.54e-22 Breast cancer; LUSC cis rs929354 0.713 rs6946660 chr7:156948648 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg04450456 chr4:17643702 FAM184B 0.34 5.64 0.3 3.58e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 0.903 rs6050482 chr20:25226327 C/T cg08601574 chr20:25228251 PYGB 0.46 7.02 0.36 1.27e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9513627 1.000 rs73556170 chr13:100121612 T/A cg25919922 chr13:100150906 NA -0.8 -6.96 -0.36 1.83e-11 Obesity-related traits; LUSC cis rs6494488 0.500 rs72744714 chr15:65016050 G/A cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg06627628 chr2:24431161 ITSN2 -0.6 -7.21 -0.37 3.78e-12 Lymphocyte counts; LUSC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg10523679 chr1:76189770 ACADM 0.86 14.2 0.61 4.1e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2286503 0.780 rs1304431 chr7:22865412 T/C cg11367502 chr7:22862612 TOMM7 0.45 5.9 0.31 8.89e-9 Fibrinogen; LUSC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg12560992 chr17:57184187 TRIM37 0.85 15.35 0.64 1.26e-40 Intelligence (multi-trait analysis); LUSC trans rs877282 0.682 rs2265092 chr10:780293 C/T cg22713356 chr15:30763199 NA -0.74 -10.75 -0.51 2.36e-23 Uric acid levels; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg18110333 chr6:292329 DUSP22 -0.72 -11.92 -0.55 1.57e-27 Menopause (age at onset); LUSC trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.26 0.41 3.47e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1865760 0.566 rs10807006 chr6:26048752 C/A cg17691542 chr6:26056736 HIST1H1C 0.52 7.9 0.4 4.01e-14 Height; LUSC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg04455712 chr21:45112962 RRP1B 0.48 9.0 0.44 1.68e-17 Mean corpuscular volume; LUSC trans rs11098499 0.863 rs11098532 chr4:120490726 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.73 0.35 7.39e-11 Corneal astigmatism; LUSC cis rs11250098 0.526 rs116793410 chr8:10770255 G/T cg21775007 chr8:11205619 TDH -0.48 -6.47 -0.33 3.55e-10 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.58e-14 Prudent dietary pattern; LUSC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg04414720 chr1:150670196 GOLPH3L -0.53 -8.21 -0.41 4.98e-15 Melanoma; LUSC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg22823121 chr1:150693482 HORMAD1 0.44 6.18 0.32 1.85e-9 Melanoma; LUSC cis rs1018836 0.923 rs2105965 chr8:91537690 T/C cg16814680 chr8:91681699 NA -0.75 -12.74 -0.57 1.46e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg03264133 chr6:25882463 NA -0.5 -9.11 -0.45 7.57e-18 Blood metabolite levels; LUSC cis rs11025559 0.631 rs11025571 chr11:20482801 C/G cg19653624 chr11:20408972 PRMT3 0.7 8.27 0.41 3.32e-15 Pursuit maintenance gain; LUSC cis rs2625529 0.590 rs2607090 chr15:72496011 C/A cg16672083 chr15:72433130 SENP8 -0.49 -7.27 -0.37 2.59e-12 Red blood cell count; LUSC cis rs68170813 0.652 rs17482494 chr7:107168487 T/C cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs7944584 0.551 rs12224672 chr11:47500400 C/T cg20307385 chr11:47447363 PSMC3 0.87 12.57 0.57 6.3e-30 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs6120849 0.707 rs752075 chr20:33591591 C/A cg24642439 chr20:33292090 TP53INP2 0.62 6.85 0.35 3.66e-11 Protein C levels; LUSC trans rs60843830 1.000 rs2290911 chr2:224919 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.34 0.49 6.44e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3771570 1.000 rs62193210 chr2:242323616 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.92 0.35 2.29e-11 Prostate cancer; LUSC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg21238619 chr17:78079768 GAA 0.28 5.69 0.3 2.78e-8 Yeast infection; LUSC cis rs1153858 1.000 rs1613559 chr15:45622116 A/G cg26924012 chr15:45694286 SPATA5L1 1.14 19.87 0.74 1.48e-58 Homoarginine levels; LUSC cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC trans rs561341 0.609 rs4795659 chr17:30187139 C/G cg20587970 chr11:113659929 NA 0.81 9.8 0.47 4.41e-20 Hip circumference adjusted for BMI; LUSC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg24531977 chr5:56204891 C5orf35 -1.02 -15.49 -0.65 3.7e-41 Initial pursuit acceleration; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg13395646 chr4:1353034 KIAA1530 -0.56 -8.41 -0.42 1.24e-15 Longevity; LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.71 0.54 9.03e-27 Prudent dietary pattern; LUSC cis rs6138458 1.000 rs1977540 chr20:24900290 G/T cg06937882 chr20:24974362 C20orf3 0.42 7.0 0.36 1.43e-11 Blood protein levels; LUSC trans rs7737355 1.000 rs6596010 chr5:130625411 G/A cg07715041 chr7:99302981 CYP3A7 -0.39 -6.26 -0.32 1.2e-9 Life satisfaction; LUSC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg22535103 chr8:58192502 C8orf71 -0.6 -6.96 -0.36 1.76e-11 Developmental language disorder (linguistic errors); LUSC cis rs9527 0.590 rs7089680 chr10:104802071 C/T cg05855489 chr10:104503620 C10orf26 -0.53 -8.18 -0.41 6.11e-15 Arsenic metabolism; LUSC cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg01579765 chr21:45077557 HSF2BP 0.55 11.45 0.53 8.04e-26 Mean corpuscular volume; LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg12564285 chr5:131593104 PDLIM4 0.56 10.76 0.51 2.22e-23 Acylcarnitine levels; LUSC cis rs2836633 0.929 rs58120977 chr21:40037346 C/T cg05519781 chr21:40033154 ERG 0.77 13.35 0.59 7.23e-33 Coronary artery disease; LUSC cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.17e-9 Blood metabolite levels; LUSC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg04166393 chr7:2884313 GNA12 -0.41 -5.74 -0.3 2.12e-8 Height; LUSC cis rs3849570 0.925 rs7641973 chr3:81910489 G/A cg07356753 chr3:81810745 GBE1 -0.68 -11.26 -0.52 3.89e-25 Waist circumference;Body mass index; LUSC cis rs977987 0.843 rs7499872 chr16:75426529 G/A cg03315344 chr16:75512273 CHST6 0.53 10.31 0.49 8.06e-22 Dupuytren's disease; LUSC trans rs2797160 1.000 rs2797161 chr6:126010789 A/G cg05039488 chr6:79577232 IRAK1BP1 0.47 6.98 0.36 1.61e-11 Endometrial cancer; LUSC trans rs853679 0.517 rs1853097 chr6:28058635 A/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.31e-9 Depression; LUSC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11644478 chr21:40555479 PSMG1 0.88 15.91 0.66 8.4e-43 Cognitive function; LUSC cis rs6696846 0.765 rs61822565 chr1:205077332 T/C cg00857998 chr1:205179979 DSTYK 0.64 10.11 0.48 3.78e-21 Red blood cell count; LUSC cis rs6541297 1.000 rs6541297 chr1:230283506 G/A cg20703242 chr1:230279135 GALNT2 0.57 8.95 0.44 2.56e-17 Coronary artery disease; LUSC trans rs7538876 0.903 rs7528427 chr1:17746273 C/T cg13009662 chr5:127419527 SLC12A2;FLJ33630 0.42 6.16 0.32 2.07e-9 Basal cell carcinoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25867650 chr15:75743273 SIN3A -0.47 -6.32 -0.33 8.29e-10 Bipolar disorder and schizophrenia; LUSC cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg25258033 chr6:167368657 RNASET2 0.4 6.02 0.31 4.59e-9 Primary biliary cholangitis; LUSC cis rs3096299 0.702 rs2086824 chr16:89471246 G/T cg06640241 chr16:89574553 SPG7 -0.51 -7.86 -0.4 5.21e-14 Multiple myeloma (IgH translocation); LUSC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg06640241 chr16:89574553 SPG7 0.91 16.62 0.67 1.26e-45 Multiple myeloma (IgH translocation); LUSC cis rs742132 0.527 rs17252870 chr6:25494666 A/C cg12310025 chr6:25882481 NA -0.44 -5.99 -0.31 5.55e-9 Uric acid levels; LUSC cis rs7607369 0.679 rs6751527 chr2:219630965 C/G cg02176678 chr2:219576539 TTLL4 0.59 10.02 0.48 7.78e-21 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg23788917 chr6:8435910 SLC35B3 0.51 7.62 0.38 2.58e-13 Motion sickness; LUSC cis rs11030122 0.632 rs11030599 chr11:4031677 A/G cg18678763 chr11:4115507 RRM1 -0.47 -6.14 -0.32 2.36e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg18252515 chr7:66147081 NA -1.21 -13.88 -0.6 6.79e-35 Diabetic kidney disease; LUSC cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.54e-29 Motion sickness; LUSC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.03 0.52 2.5300000000000002e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs4285028 0.747 rs7153 chr3:121383297 G/A cg11130432 chr3:121712080 ILDR1 -0.57 -8.29 -0.41 2.88e-15 Multiple sclerosis; LUSC cis rs10028773 0.700 rs7671797 chr4:120248157 A/G cg09307838 chr4:120376055 NA 0.69 10.52 0.5 1.51e-22 Educational attainment; LUSC cis rs11608355 0.960 rs10774691 chr12:109859830 C/T cg19025524 chr12:109796872 NA -0.38 -5.96 -0.31 6.58e-9 Neuroticism; LUSC cis rs4499344 0.633 rs166310 chr19:33155187 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.42 0.53 1.02e-25 Mean platelet volume; LUSC cis rs1322512 1.000 rs2250006 chr6:153006401 T/A cg27316956 chr6:152958899 SYNE1 0.34 5.98 0.31 5.72e-9 Tonometry; LUSC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg17330251 chr7:94953956 PON1 0.36 5.89 0.31 9.64e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7617480 0.648 rs4858800 chr3:48755820 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.61 9.37 0.46 1.13e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs11264213 0.901 rs72661641 chr1:36448130 A/G cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.33e-14 Schizophrenia; LUSC cis rs868036 0.681 rs28626095 chr15:68066729 T/C cg08079166 chr15:68083412 MAP2K5 0.4 7.31 0.37 1.98e-12 Restless legs syndrome; LUSC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC cis rs7799006 0.527 rs6967286 chr7:2212758 C/A cg02951883 chr7:2050386 MAD1L1 -0.39 -6.65 -0.34 1.23e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9300255 0.568 rs3018098 chr12:123654812 T/C cg00376283 chr12:123451042 ABCB9 0.65 8.24 0.41 3.99e-15 Neutrophil percentage of white cells; LUSC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.66 0.65 7.59e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9549260 0.592 rs9532588 chr13:41302913 G/A cg21288729 chr13:41239152 FOXO1 0.54 7.91 0.4 3.9e-14 Red blood cell count; LUSC cis rs9467711 0.606 rs9393706 chr6:26361500 G/A cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs4629180 0.959 rs11896771 chr2:102098328 T/C cg04415270 chr2:102091202 RFX8 -0.54 -8.56 -0.42 4.3e-16 Chronic rhinosinusitis with nasal polyps; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg07677032 chr17:61819896 STRADA -0.5 -8.38 -0.42 1.46e-15 Prudent dietary pattern; LUSC cis rs6545883 0.826 rs777591 chr2:61417617 A/G cg15711740 chr2:61764176 XPO1 -0.43 -6.77 -0.35 5.76e-11 Tuberculosis; LUSC cis rs1729951 0.575 rs1654925 chr3:136690391 C/T cg21827317 chr3:136751795 NA -0.38 -6.78 -0.35 5.43e-11 Neuroticism; LUSC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Parkinson's disease; LUSC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg14664628 chr15:75095509 CSK -0.59 -9.1 -0.45 8.28e-18 Breast cancer; LUSC cis rs1577917 0.629 rs7761762 chr6:86205968 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.39 6.27 0.32 1.09e-9 Response to antipsychotic treatment; LUSC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.82 -0.43 6.62e-17 Lung cancer; LUSC cis rs4478858 0.684 rs3737755 chr1:31744168 G/A cg00250761 chr1:31883323 NA -0.35 -8.37 -0.42 1.61e-15 Alcohol dependence; LUSC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg13939156 chr17:80058883 NA 0.33 6.42 0.33 4.73e-10 Life satisfaction; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14159367 chr14:82000258 SEL1L 0.44 6.25 0.32 1.27e-9 Mosquito bite size; LUSC cis rs4692589 0.581 rs34149802 chr4:170960284 A/G cg19918862 chr4:170955249 NA 0.36 6.68 0.34 9.71e-11 Anxiety disorder; LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.05 -0.31 3.82e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2742417 1.000 rs1534876 chr3:45741257 G/T cg09608765 chr3:45636137 LIMD1 -0.39 -7.72 -0.39 1.37e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.53 -0.34 2.52e-10 Colorectal cancer; LUSC cis rs1865760 1.000 rs9348698 chr6:25929689 T/A cg16482183 chr6:26056742 HIST1H1C 0.46 6.72 0.35 7.77e-11 Height; LUSC cis rs6500602 0.727 rs3761681 chr16:4566857 C/T cg08645402 chr16:4508243 NA 0.53 9.08 0.45 9.43e-18 Schizophrenia; LUSC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg05872129 chr22:39784769 NA -0.6 -10.9 -0.51 7.18e-24 Intelligence (multi-trait analysis); LUSC cis rs17685 0.753 rs1806885 chr7:75785612 T/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg16586182 chr3:47516702 SCAP 0.52 7.46 0.38 7.78e-13 Birth weight; LUSC cis rs6556937 0.627 rs4590196 chr5:95997285 G/T cg07690455 chr5:95997198 CAST 0.49 6.73 0.35 7.37e-11 Blood protein levels; LUSC cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg24558204 chr6:135376177 HBS1L 0.58 8.54 0.42 4.94e-16 High light scatter reticulocyte percentage of red cells; LUSC cis rs11190604 0.767 rs10509743 chr10:102190406 C/T cg07080220 chr10:102295463 HIF1AN 0.59 7.86 0.4 5.23e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg03146154 chr1:46216737 IPP -0.58 -8.42 -0.42 1.11e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg24846343 chr22:24311635 DDTL 0.77 17.35 0.69 1.61e-48 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs73200209 0.744 rs74349961 chr12:116467560 T/C cg01776926 chr12:116560359 MED13L -0.51 -6.1 -0.32 2.88e-9 Total body bone mineral density; LUSC cis rs2050392 0.517 rs687036 chr10:30761249 G/A cg18806716 chr10:30721971 MAP3K8 -0.59 -9.72 -0.47 7.71e-20 Inflammatory bowel disease; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg11766577 chr21:47581405 C21orf56 0.52 8.03 0.4 1.67e-14 Testicular germ cell tumor; LUSC cis rs12220238 1.000 rs73284257 chr10:76000710 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.8 0.35 4.87e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1044826 0.692 rs169824 chr3:139235006 G/C cg00490450 chr3:139108681 COPB2 -0.45 -6.95 -0.36 1.95e-11 Obesity-related traits; LUSC cis rs7917772 0.582 rs4919663 chr10:104363293 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 11.03 0.52 2.51e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10876993 0.890 rs774891 chr12:58068571 G/A cg18357645 chr12:58087776 OS9 0.54 8.19 0.41 5.5e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg08999081 chr20:33150536 PIGU 0.54 11.01 0.52 2.88e-24 Coronary artery disease; LUSC cis rs8060686 0.544 rs1124993 chr16:68114626 T/C cg04539111 chr16:67997858 SLC12A4 -0.43 -5.96 -0.31 6.31e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs59104589 0.617 rs56663202 chr2:242262311 A/G cg14842376 chr2:242211374 HDLBP 0.53 5.99 0.31 5.31e-9 Fibrinogen levels; LUSC cis rs4629710 0.562 rs3798252 chr6:131583758 A/T cg12606694 chr6:131520996 AKAP7 0.62 9.34 0.45 1.43e-18 Multiple myeloma (IgH translocation); LUSC cis rs1670533 0.615 rs59985183 chr4:1087171 G/T cg02018176 chr4:1364513 KIAA1530 0.43 6.09 0.32 3.17e-9 Recombination rate (females); LUSC cis rs854765 0.547 rs28537385 chr17:17902135 G/A cg16928487 chr17:17741425 SREBF1 -0.36 -6.72 -0.35 7.67e-11 Total body bone mineral density; LUSC cis rs4969178 0.560 rs4969182 chr17:76393030 T/C cg20026190 chr17:76395443 PGS1 0.33 5.71 0.3 2.47e-8 HDL cholesterol levels; LUSC cis rs2354432 0.556 rs34602039 chr1:146850972 G/A cg25205988 chr1:146714368 CHD1L -0.89 -7.6 -0.38 3.04e-13 Mitochondrial DNA levels; LUSC cis rs9660992 0.710 rs4951184 chr1:205240659 A/T cg21643547 chr1:205240462 TMCC2 -0.52 -10.14 -0.49 3.04e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg02782426 chr3:40428986 ENTPD3 0.33 6.33 0.33 7.8e-10 Renal cell carcinoma; LUSC cis rs55665837 0.559 rs9667144 chr11:14421101 C/T cg19336497 chr11:14380999 RRAS2 0.52 11.15 0.52 9.69e-25 Vitamin D levels; LUSC cis rs7580658 0.895 rs9636237 chr2:128076022 T/C cg09760422 chr2:128146352 NA -0.29 -6.15 -0.32 2.2e-9 Protein C levels; LUSC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.42 0.33 4.63e-10 Cerebrospinal P-tau181p levels; LUSC cis rs7312933 0.510 rs10880223 chr12:42413443 G/A cg17420585 chr12:42539391 GXYLT1 -0.55 -12.26 -0.56 8.8e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.83 0.39 6.52e-14 Blood metabolite levels; LUSC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg15557168 chr22:42548783 NA -0.44 -6.8 -0.35 4.69e-11 Schizophrenia; LUSC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg18230493 chr5:56204884 C5orf35 -0.57 -9.05 -0.44 1.17e-17 Coronary artery disease; LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg14092988 chr3:52407081 DNAH1 0.33 6.32 0.33 8.52e-10 Bipolar disorder; LUSC trans rs877282 1.000 rs7100358 chr10:773681 G/A cg13042288 chr15:90349979 ANPEP -0.48 -6.93 -0.35 2.24e-11 Uric acid levels; LUSC cis rs9527 0.590 rs12415199 chr10:104895536 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg13010199 chr12:38710504 ALG10B 0.65 10.25 0.49 1.26e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg05340658 chr4:99064831 C4orf37 0.65 11.05 0.52 2.15e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.78 -0.3 1.67e-8 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.91 0.48 1.76e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10751667 0.643 rs10902237 chr11:944801 C/A ch.11.42038R chr11:967971 AP2A2 0.41 6.08 0.32 3.21e-9 Alzheimer's disease (late onset); LUSC cis rs4561483 0.801 rs33623 chr16:12007435 A/G cg08843971 chr16:11963173 GSPT1 0.52 8.01 0.4 1.87e-14 Testicular germ cell tumor; LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg08859206 chr1:53392774 SCP2 0.56 9.89 0.48 2.05e-20 Monocyte count; LUSC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC trans rs1459104 0.704 rs12806568 chr11:54892378 G/A cg15704280 chr7:45808275 SEPT13 0.76 6.64 0.34 1.24e-10 Body mass index; LUSC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg08219700 chr8:58056026 NA 0.72 7.76 0.39 1.05e-13 Developmental language disorder (linguistic errors); LUSC cis rs9389248 0.690 rs6939543 chr6:135255143 A/G cg22676075 chr6:135203613 NA -0.65 -10.25 -0.49 1.27e-21 High light scatter reticulocyte percentage of red cells; LUSC cis rs3126085 0.877 rs1552992 chr1:152171625 C/G cg26876637 chr1:152193138 HRNR 0.45 6.66 0.34 1.16e-10 Atopic dermatitis; LUSC cis rs4889855 0.556 rs4890039 chr17:78517883 C/T cg16591659 chr17:78472290 NA 0.32 5.68 0.3 2.99e-8 Fractional excretion of uric acid; LUSC cis rs12368653 0.666 rs1050045 chr12:58115271 A/G cg15848620 chr12:58087721 OS9 -0.39 -5.65 -0.3 3.4e-8 Multiple sclerosis; LUSC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg09359103 chr1:154839909 KCNN3 -0.69 -15.34 -0.64 1.36e-40 Prostate cancer; LUSC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg04871131 chr7:94954202 PON1 -0.39 -6.18 -0.32 1.85e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs76878669 0.606 rs1785639 chr11:66100430 G/A cg24851651 chr11:66362959 CCS -0.38 -6.05 -0.31 3.84e-9 Educational attainment (years of education); LUSC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg07636037 chr3:49044803 WDR6 0.44 6.51 0.34 2.69e-10 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg15448220 chr1:150897856 SETDB1 0.41 6.02 0.31 4.61e-9 Melanoma; LUSC cis rs7980687 0.657 rs10744151 chr12:123723735 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.41 -0.33 4.87e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -7.86 -0.4 5.3e-14 Reticulocyte count; LUSC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg02574844 chr11:5959923 NA -0.42 -6.09 -0.32 3.08e-9 DNA methylation (variation); LUSC cis rs9549367 0.707 rs9549353 chr13:113843427 G/A cg18105134 chr13:113819100 PROZ -0.75 -10.61 -0.5 7.22e-23 Platelet distribution width; LUSC cis rs10754283 0.934 rs7529653 chr1:90111851 G/A cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs922692 1.000 rs4887077 chr15:78978364 A/G cg00540400 chr15:79124168 NA 0.34 5.75 0.3 2.02e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs78707713 0.512 rs35793747 chr10:71182165 A/G cg14388049 chr10:71211838 TSPAN15 -0.31 -5.71 -0.3 2.44e-8 Venous thromboembolism; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs10782582 0.609 rs76260657 chr1:76338017 C/T cg03433033 chr1:76189801 ACADM -0.42 -6.05 -0.31 3.96e-9 Daytime sleep phenotypes; LUSC cis rs12497850 1.000 rs4858831 chr3:48735558 C/T cg07636037 chr3:49044803 WDR6 0.91 15.67 0.65 7.28e-42 Parkinson's disease; LUSC cis rs1044826 0.642 rs9826544 chr3:139162831 A/G cg15131784 chr3:139108705 COPB2 0.42 6.85 0.35 3.55e-11 Obesity-related traits; LUSC cis rs1003719 0.708 rs8126491 chr21:38551219 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.55e-22 Eye color traits; LUSC cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.21 29.0 0.85 2.96e-93 Chronic sinus infection; LUSC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg04121214 chr22:50244548 NA -0.32 -5.97 -0.31 5.93e-9 Schizophrenia; LUSC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.09 0.55 3.63e-28 Cognitive test performance; LUSC cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg08873628 chr1:175162347 KIAA0040 0.39 5.72 0.3 2.39e-8 Alcohol dependence; LUSC cis rs476633 0.691 rs28409265 chr15:41539404 G/A cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.34 -0.42 1.91e-15 Glomerular filtration rate (creatinine); LUSC trans rs9929218 0.559 rs12923775 chr16:68756450 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.01 20.98 0.75 6.06e-63 Colorectal cancer; LUSC cis rs2290416 0.892 rs76108894 chr8:144673533 G/A cg08017634 chr8:144659831 NAPRT1 0.7 6.06 0.31 3.64e-9 Attention deficit hyperactivity disorder; LUSC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9747201 1.000 rs36048409 chr17:80096961 T/A cg18209359 chr17:80159595 CCDC57 0.39 6.44 0.33 4.06e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6570726 0.526 rs4896805 chr6:145735429 C/A cg23711669 chr6:146136114 FBXO30 -0.52 -7.96 -0.4 2.73e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2625529 0.652 rs11072350 chr15:72464609 T/G cg16672083 chr15:72433130 SENP8 0.48 7.98 0.4 2.35e-14 Red blood cell count; LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg11766577 chr21:47581405 C21orf56 -0.54 -8.17 -0.41 6.53e-15 Testicular germ cell tumor; LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg13047869 chr3:10149882 C3orf24 0.6 8.27 0.41 3.15e-15 Alzheimer's disease; LUSC cis rs2708377 0.929 rs73066828 chr12:11270654 A/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.81 7.88 0.4 4.71e-14 Bitter taste perception; LUSC cis rs1670533 1.000 rs7669622 chr4:1058659 A/G cg02018176 chr4:1364513 KIAA1530 0.43 5.98 0.31 5.7e-9 Recombination rate (females); LUSC trans rs11098499 0.954 rs10006525 chr4:120408931 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.56 0.34 2.07e-10 Corneal astigmatism; LUSC cis rs73206853 0.841 rs55885183 chr12:110877682 A/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2348418 0.681 rs10771435 chr12:28735702 C/T cg13890972 chr12:28721907 NA -0.37 -6.35 -0.33 7.09e-10 Lung function (FVC);Lung function (FEV1); LUSC cis rs8114671 0.967 rs2065979 chr20:33767690 T/C cg07148914 chr20:33460835 GGT7 0.47 6.93 0.35 2.24e-11 Height; LUSC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1728785 0.901 rs821169 chr16:68630184 C/T cg02972257 chr16:68554789 NA -0.5 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs826838 0.868 rs864324 chr12:39122853 A/G cg26384229 chr12:38710491 ALG10B 0.71 12.45 0.56 1.7e-29 Heart rate; LUSC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg14440974 chr22:39074834 NA -0.36 -5.92 -0.31 7.79e-9 Menopause (age at onset); LUSC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg18230493 chr5:56204884 C5orf35 -0.54 -8.35 -0.42 1.85e-15 Coronary artery disease; LUSC cis rs981844 0.712 rs6855093 chr4:154754050 A/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.26 -0.32 1.16e-9 Response to statins (LDL cholesterol change); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07032473 chr8:95274411 GEM 0.42 6.45 0.33 3.86e-10 Triglycerides; LUSC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg06697600 chr4:7070879 GRPEL1 -0.4 -6.66 -0.34 1.16e-10 Monocyte percentage of white cells; LUSC trans rs12543645 0.609 rs35112858 chr8:10277269 C/T cg15556689 chr8:8085844 FLJ10661 0.45 6.14 0.32 2.32e-9 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24464101 chr4:38690487 KLF3 0.41 6.29 0.33 1.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs524023 0.958 rs2021860 chr11:64361384 G/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.39 -0.49 4.39e-22 Urate levels in obese individuals; LUSC cis rs7089973 0.604 rs11196929 chr10:116582080 G/C cg25233709 chr10:116636983 FAM160B1 0.38 6.63 0.34 1.36e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2273669 0.667 rs117412830 chr6:109336617 A/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.91 -0.31 8.57e-9 Prostate cancer; LUSC cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs9359856 0.673 rs1179897 chr6:90318624 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -8.05 -0.4 1.45e-14 Bipolar disorder; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg00149659 chr3:10157352 C3orf10 0.89 11.92 0.55 1.53e-27 Alzheimer's disease; LUSC cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.39 6.02 0.31 4.63e-9 Multiple sclerosis; LUSC cis rs763121 0.853 rs5757141 chr22:38957483 G/A cg06022373 chr22:39101656 GTPBP1 0.78 11.75 0.54 6.69e-27 Menopause (age at onset); LUSC cis rs858239 0.600 rs7776649 chr7:23119317 C/T cg23682824 chr7:23144976 KLHL7 0.41 5.88 0.31 1.01e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs2439831 0.850 rs8023458 chr15:44080939 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.89 8.95 0.44 2.51e-17 Lung cancer in ever smokers; LUSC cis rs2304069 0.954 rs4705408 chr5:149412545 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.77 -10.74 -0.51 2.53e-23 HIV-1 control; LUSC cis rs9309473 1.000 rs7594511 chr2:73681639 A/G cg20560298 chr2:73613845 ALMS1 -0.44 -6.35 -0.33 6.9e-10 Metabolite levels; LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg11062466 chr8:58055876 NA 0.65 8.59 0.43 3.4e-16 Developmental language disorder (linguistic errors); LUSC cis rs240764 0.658 rs60658003 chr6:101201191 C/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg18099408 chr3:52552593 STAB1 -0.35 -6.03 -0.31 4.35e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.63 0.34 1.34e-10 Lung cancer; LUSC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg23283495 chr1:209979779 IRF6 0.64 7.9 0.4 4.2e-14 Cleft lip with or without cleft palate; LUSC cis rs155346 1.000 rs265143 chr5:139397066 A/C cg01090482 chr5:139365336 NRG2 -0.37 -6.18 -0.32 1.87e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg18225595 chr11:63971243 STIP1 0.49 6.1 0.32 2.88e-9 Mean platelet volume; LUSC trans rs877282 1.000 rs11253366 chr10:773386 C/T cg13042288 chr15:90349979 ANPEP -0.48 -6.91 -0.35 2.46e-11 Uric acid levels; LUSC cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.86 0.44 4.97e-17 Axial length; LUSC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg06740227 chr12:86229804 RASSF9 0.43 6.76 0.35 6.18e-11 Major depressive disorder; LUSC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg11279151 chr3:101281821 RG9MTD1 -0.4 -5.73 -0.3 2.23e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs11031096 0.711 rs4910890 chr11:4153407 C/T cg18678763 chr11:4115507 RRM1 -0.53 -7.61 -0.38 2.73e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2014572 0.901 rs35658377 chr19:57755627 T/G cg24459738 chr19:57751996 ZNF805 -0.52 -7.69 -0.39 1.67e-13 Hyperactive-impulsive symptoms; LUSC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg04369109 chr6:150039330 LATS1 -0.57 -8.54 -0.42 4.92e-16 Lung cancer; LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg05368731 chr17:41323189 NBR1 0.93 15.69 0.65 5.75e-42 Menopause (age at onset); LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg00814883 chr7:100076585 TSC22D4 -0.67 -8.49 -0.42 6.81e-16 Platelet count; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg16393715 chr7:1948819 MAD1L1 0.34 5.82 0.3 1.35e-8 Bipolar disorder and schizophrenia; LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg00149659 chr3:10157352 C3orf10 1.0 14.66 0.63 6.41e-38 Alzheimer's disease; LUSC cis rs12681287 0.647 rs2953510 chr8:87341914 T/C cg27223183 chr8:87520930 FAM82B -0.54 -7.1 -0.36 7.54e-12 Caudate activity during reward; LUSC cis rs7959452 0.570 rs10878964 chr12:69720691 T/G cg20891283 chr12:69753455 YEATS4 0.67 10.51 0.5 1.69e-22 Blood protein levels; LUSC trans rs4911259 0.552 rs6058925 chr20:31465374 G/A cg09781936 chr22:19749961 TBX1 -0.34 -6.01 -0.31 4.74e-9 Inflammatory bowel disease; LUSC cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg24596788 chr1:163392923 NA -0.43 -7.19 -0.37 4.22e-12 Motion sickness; LUSC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.5 -0.34 2.94e-10 Alzheimer's disease (late onset); LUSC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9837602 0.872 rs35154249 chr3:99738230 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 5.74 0.3 2.12e-8 Breast cancer; LUSC cis rs317689 0.918 rs610192 chr12:69739941 T/C cg11871910 chr12:69753446 YEATS4 0.6 7.95 0.4 2.88e-14 Response to diuretic therapy; LUSC cis rs7917772 0.582 rs4919665 chr10:104366042 C/T cg05855489 chr10:104503620 C10orf26 0.49 7.55 0.38 4.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg05025164 chr4:1340916 KIAA1530 0.39 5.83 0.3 1.34e-8 Obesity-related traits; LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs6752107 1.000 rs34123137 chr2:234167881 T/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.73 12.11 0.55 3.07e-28 Crohn's disease;Inflammatory bowel disease; LUSC cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs859767 0.741 rs10803548 chr2:135396738 C/A cg12500956 chr2:135428796 TMEM163 -0.27 -6.28 -0.32 1.07e-9 Neuroticism; LUSC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.28 0.59 1.28e-32 Total body bone mineral density; LUSC cis rs6429082 0.818 rs291383 chr1:235643100 G/A cg26050004 chr1:235667680 B3GALNT2 0.61 8.37 0.42 1.62e-15 Adiposity; LUSC cis rs8049040 0.609 rs9940485 chr16:71486105 C/T cg08717414 chr16:71523259 ZNF19 -0.42 -5.95 -0.31 6.65e-9 Blood protein levels; LUSC cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg08085267 chr17:45401833 C17orf57 0.54 8.83 0.44 6.02e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg09184832 chr6:79620586 NA -0.45 -7.35 -0.37 1.58e-12 Intelligence (multi-trait analysis); LUSC cis rs10193935 0.901 rs6544536 chr2:42522042 G/A cg27598129 chr2:42591480 NA -0.59 -8.4 -0.42 1.31e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.92 -0.4 3.5e-14 Schizophrenia; LUSC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg11965913 chr1:205819406 PM20D1 0.47 6.67 0.34 1.06e-10 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg21535247 chr6:8435926 SLC35B3 0.57 9.0 0.44 1.76e-17 Motion sickness; LUSC cis rs9467711 0.651 rs16891264 chr6:26072445 C/T cg08501292 chr6:25962987 TRIM38 -0.65 -6.0 -0.31 5.17e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9625935 0.748 rs2412974 chr22:30539821 C/T cg11564601 chr22:30592435 NA -0.33 -5.73 -0.3 2.2e-8 Tonsillectomy; LUSC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg17173187 chr15:85201210 NMB 0.37 6.56 0.34 2.08e-10 Schizophrenia; LUSC cis rs10791323 0.559 rs10750548 chr11:133729469 A/G cg00579200 chr11:133705235 NA -0.4 -5.98 -0.31 5.83e-9 Childhood ear infection; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15357518 chr19:36120356 RBM42 0.46 6.81 0.35 4.48e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg00857998 chr1:205179979 DSTYK 0.57 8.6 0.43 3.18e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.02 0.58 1.28e-31 Chronic sinus infection; LUSC trans rs7824557 0.564 rs2572389 chr8:11236392 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.83 -0.39 6.41e-14 Retinal vascular caliber; LUSC cis rs56283067 0.578 rs12203052 chr6:45398958 C/G cg18551225 chr6:44695536 NA -0.39 -5.83 -0.3 1.34e-8 Total body bone mineral density; LUSC trans rs60843830 1.000 rs6709534 chr2:217334 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.47 0.5 2.28e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2070488 0.662 rs6599202 chr3:38480651 T/C cg24069376 chr3:38537580 EXOG 0.35 6.29 0.33 9.81e-10 Electrocardiographic conduction measures; LUSC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.82 -0.35 4.24e-11 Total body bone mineral density; LUSC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg12923728 chr3:195709715 SDHAP1 -0.79 -12.47 -0.56 1.5e-29 Pancreatic cancer; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg24827620 chr21:34961125 DONSON 0.49 6.36 0.33 6.52e-10 Response to Homoharringtonine (cytotoxicity); LUSC trans rs890100 0.673 rs13420553 chr2:56660502 T/C cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.75e-9 Gut microbiome composition (summer); LUSC cis rs9311676 0.656 rs11712139 chr3:58384775 C/T cg26110898 chr3:58419937 PDHB 0.44 7.1 0.36 7.5e-12 Systemic lupus erythematosus; LUSC cis rs765787 0.530 rs11636410 chr15:45535913 A/C cg25801113 chr15:45476975 SHF -0.33 -6.58 -0.34 1.86e-10 Uric acid levels; LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -11.91 -0.55 1.71e-27 Platelet count; LUSC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg06558623 chr16:89946397 TCF25 1.11 9.74 0.47 6.79e-20 Skin colour saturation; LUSC cis rs60843830 0.661 rs6755432 chr2:106692 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.44 6.52 0.34 2.54e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6570726 0.526 rs4895674 chr6:145735860 T/G cg23711669 chr6:146136114 FBXO30 -0.52 -7.9 -0.4 4.19e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg21782813 chr7:2030301 MAD1L1 0.59 10.2 0.49 1.85e-21 Bipolar disorder and schizophrenia; LUSC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg02380750 chr20:61661411 NA 0.35 6.16 0.32 2.04e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7241530 0.717 rs9949518 chr18:75889092 C/A cg14642773 chr18:75888474 NA 0.36 6.01 0.31 4.91e-9 Educational attainment (years of education); LUSC cis rs11105298 0.891 rs10858854 chr12:89835728 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.1 -0.36 7.74e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11828289 0.660 rs79043125 chr11:23203646 T/A cg20040320 chr11:23191996 NA -0.58 -6.07 -0.31 3.57e-9 Cancer; LUSC cis rs897984 0.513 rs17839568 chr16:31099783 T/C cg02466173 chr16:30829666 NA -0.5 -9.54 -0.46 3.13e-19 Dementia with Lewy bodies; LUSC cis rs2806561 0.808 rs12128178 chr1:23354814 C/T cg19743168 chr1:23544995 NA -0.44 -9.11 -0.45 7.89e-18 Height; LUSC trans rs10435719 0.647 rs10092605 chr8:11787395 T/G cg08975724 chr8:8085496 FLJ10661 0.49 7.26 0.37 2.7e-12 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg05025164 chr4:1340916 KIAA1530 0.42 6.34 0.33 7.29e-10 Obesity-related traits; LUSC cis rs58785573 0.504 rs12646137 chr4:38609650 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.48 6.35 0.33 7.02e-10 Lymphocyte percentage of white cells; LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg24813613 chr7:1882135 MAD1L1 -0.43 -7.3 -0.37 2.18e-12 Bipolar disorder and schizophrenia; LUSC cis rs2274273 0.905 rs8007614 chr14:55586575 A/G cg04306507 chr14:55594613 LGALS3 0.52 11.6 0.54 2.29e-26 Protein biomarker; LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg13047869 chr3:10149882 C3orf24 0.57 7.97 0.4 2.55e-14 Alzheimer's disease; LUSC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg18876405 chr7:65276391 NA 0.64 10.88 0.51 8.36e-24 Aortic root size; LUSC cis rs8017423 0.935 rs11159960 chr14:90740012 C/T cg04374321 chr14:90722782 PSMC1 -0.69 -10.43 -0.5 3.22e-22 Mortality in heart failure; LUSC cis rs1044826 0.642 rs6787649 chr3:139193321 C/T cg15131784 chr3:139108705 COPB2 0.39 6.29 0.33 9.81e-10 Obesity-related traits; LUSC cis rs4780401 0.546 rs3743588 chr16:11836508 G/A cg01061890 chr16:11836724 TXNDC11 0.64 8.33 0.41 2.13e-15 Rheumatoid arthritis; LUSC cis rs637571 0.565 rs633800 chr11:65638719 G/A cg26695010 chr11:65641043 EFEMP2 0.58 8.66 0.43 2.09e-16 Eosinophil percentage of white cells; LUSC cis rs8040855 0.621 rs6496796 chr15:85726848 T/C cg04831495 chr15:85060580 GOLGA6L5 0.4 6.48 0.33 3.23e-10 Bulimia nervosa; LUSC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.88 0.48 2.24e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12620999 0.555 rs4073396 chr2:238111471 A/C cg23555395 chr2:238036564 NA 0.33 6.46 0.33 3.79e-10 Systemic lupus erythematosus; LUSC cis rs7605827 0.930 rs7577436 chr2:15528281 C/T cg19274914 chr2:15703543 NA 0.45 8.62 0.43 2.64e-16 Educational attainment (years of education); LUSC cis rs7829975 0.711 rs4481596 chr8:8704330 G/C cg06636001 chr8:8085503 FLJ10661 0.66 10.5 0.5 1.84e-22 Mood instability; LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.1 -0.45 8.15e-18 Bipolar disorder; LUSC cis rs8072100 0.576 rs7216112 chr17:45406345 C/T cg08085267 chr17:45401833 C17orf57 0.5 6.75 0.35 6.59e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg05802129 chr4:122689817 NA -0.37 -6.69 -0.34 9.46e-11 Type 2 diabetes; LUSC cis rs2019216 0.500 rs2169916 chr17:21884670 G/C cg22648282 chr17:21454238 C17orf51 -0.54 -7.76 -0.39 1.06e-13 Pelvic organ prolapse; LUSC cis rs9534288 0.699 rs9534320 chr13:46665572 A/G cg15192986 chr13:46630673 CPB2 -0.69 -10.15 -0.49 2.77e-21 Blood protein levels; LUSC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg22508957 chr16:3507546 NAT15 0.85 11.0 0.52 3.09e-24 Tuberculosis; LUSC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg20203395 chr5:56204925 C5orf35 -0.6 -9.13 -0.45 6.88e-18 Coronary artery disease; LUSC cis rs4722404 0.620 rs6978200 chr7:3118835 A/G cg19214707 chr7:3157722 NA -0.35 -5.83 -0.3 1.31e-8 Atopic dermatitis; LUSC cis rs7100689 0.646 rs11202751 chr10:82147802 G/A cg01528321 chr10:82214614 TSPAN14 0.89 13.66 0.6 4.65e-34 Post bronchodilator FEV1; LUSC cis rs11105298 0.891 rs10858889 chr12:89902604 G/A cg00757033 chr12:89920650 WDR51B 0.6 10.4 0.49 4.04e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7107174 0.786 rs2450134 chr11:77925778 A/G cg02023728 chr11:77925099 USP35 0.54 7.64 0.39 2.3e-13 Testicular germ cell tumor; LUSC cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg03877680 chr5:178157825 ZNF354A 0.69 10.1 0.48 4.28e-21 Neutrophil percentage of white cells; LUSC cis rs1371867 0.846 rs1660348 chr8:101315248 A/G cg00191853 chr8:101177733 SPAG1 -0.39 -6.5 -0.33 2.97e-10 Atrioventricular conduction; LUSC cis rs7597155 0.875 rs6752048 chr2:69986136 C/T cg02498382 chr2:70120550 SNRNP27 -0.24 -5.73 -0.3 2.23e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11642862 1.000 rs11642466 chr16:30781942 A/G cg02466173 chr16:30829666 NA -0.67 -7.21 -0.37 3.66e-12 Tonsillectomy; LUSC cis rs34734847 0.814 rs17847 chr12:121149475 A/G cg27246729 chr12:121163418 ACADS 0.41 6.5 0.34 2.86e-10 Mean corpuscular volume; LUSC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.95 0.31 6.63e-9 Lung cancer; LUSC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg17366294 chr4:99064904 C4orf37 0.55 9.66 0.47 1.25e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs3820068 0.608 rs58140482 chr1:16043979 A/G cg13390004 chr1:15929781 NA 0.42 6.82 0.35 4.38e-11 Systolic blood pressure; LUSC cis rs73195822 0.667 rs59789826 chr12:111235110 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 6.72 0.34 8.08e-11 Itch intensity from mosquito bite; LUSC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg26314531 chr2:26401878 FAM59B -0.68 -9.19 -0.45 4.28e-18 Gut microbiome composition (summer); LUSC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg26850624 chr5:429559 AHRR -0.43 -8.39 -0.42 1.35e-15 Cystic fibrosis severity; LUSC trans rs11722228 0.508 rs2241473 chr4:10085949 G/A cg26043149 chr18:55253948 FECH 0.94 14.08 0.61 1.14e-35 Gout;Urate levels;Serum uric acid levels; LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg06145435 chr7:1022769 CYP2W1 0.32 6.99 0.36 1.54e-11 Longevity;Endometriosis; LUSC cis rs440932 1.000 rs440932 chr8:9026929 T/C cg15556689 chr8:8085844 FLJ10661 0.43 6.08 0.32 3.31e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg02079420 chr8:82753780 SNX16 0.4 6.82 0.35 4.3e-11 Diastolic blood pressure; LUSC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg14668632 chr7:2872130 GNA12 -0.45 -6.78 -0.35 5.42e-11 Height; LUSC cis rs4664304 0.772 rs17830558 chr2:160878364 A/C cg23995753 chr2:160760732 LY75 -0.34 -6.33 -0.33 7.96e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2387326 0.717 rs10829335 chr10:129943515 A/G cg16087940 chr10:129947807 NA -0.39 -5.81 -0.3 1.48e-8 Select biomarker traits; LUSC cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.9e-23 Bladder cancer; LUSC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.01 0.4 1.9e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9733 0.744 rs12758227 chr1:150844583 C/A cg13175981 chr1:150552382 MCL1 0.45 6.23 0.32 1.4e-9 Tonsillectomy; LUSC cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg24450063 chr1:156163899 SLC25A44 1.07 17.23 0.69 4.64e-48 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.02e-11 Lung cancer; LUSC cis rs1419980 0.673 rs12146828 chr12:7739341 C/G cg25828445 chr12:7781288 NA -0.65 -6.78 -0.35 5.52e-11 HDL cholesterol levels; LUSC cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg16230307 chr14:35515116 FAM177A1 0.79 10.05 0.48 6.13e-21 Psoriasis; LUSC cis rs4319547 0.695 rs6489002 chr12:122929822 T/C cg23029597 chr12:123009494 RSRC2 -0.74 -9.13 -0.45 6.67e-18 Body mass index; LUSC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg04398451 chr17:18023971 MYO15A -0.46 -7.38 -0.37 1.31e-12 Total body bone mineral density; LUSC cis rs9326248 0.581 rs10892072 chr11:116960313 G/A cg11861562 chr11:117069780 TAGLN 0.32 6.28 0.32 1.05e-9 Blood protein levels; LUSC cis rs72634258 0.945 rs4908724 chr1:8119251 G/T cg26816564 chr1:7831052 VAMP3 0.49 5.86 0.31 1.1e-8 Inflammatory bowel disease; LUSC cis rs7954584 0.813 rs1523261 chr12:122462877 C/A cg22618164 chr12:122356400 WDR66 0.41 5.75 0.3 2.05e-8 Mean corpuscular volume; LUSC cis rs1957429 0.614 rs79411360 chr14:65378856 T/C cg23373153 chr14:65346875 NA -0.98 -7.72 -0.39 1.39e-13 Pediatric areal bone mineral density (radius); LUSC trans rs6582630 0.502 rs11181230 chr12:38300085 A/G cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg07148914 chr20:33460835 GGT7 0.54 8.32 0.41 2.3e-15 Height; LUSC cis rs10740039 0.883 rs1561850 chr10:62391341 T/A cg18175470 chr10:62150864 ANK3 -0.46 -6.86 -0.35 3.42e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7424096 0.651 rs58370258 chr2:37167191 T/C cg14987922 chr2:37194071 STRN 0.47 6.25 0.32 1.24e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs17604090 0.816 rs10248839 chr7:29697253 T/C cg19413766 chr7:29689036 LOC646762 -0.64 -7.64 -0.39 2.34e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs9473147 0.516 rs6904764 chr6:47503497 A/T cg12968598 chr6:47444699 CD2AP 0.53 8.07 0.4 1.3e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.21 0.32 1.62e-9 Schizophrenia; LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg09877947 chr5:131593287 PDLIM4 -0.46 -7.03 -0.36 1.19e-11 Breast cancer; LUSC cis rs12908161 1.000 rs35630683 chr15:85349231 T/C cg17507749 chr15:85114479 UBE2QP1 0.54 6.49 0.33 3.11e-10 Schizophrenia; LUSC cis rs2688608 1.000 rs2675680 chr10:75658864 T/C cg23231163 chr10:75533350 FUT11 -0.37 -6.05 -0.31 3.89e-9 Inflammatory bowel disease; LUSC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg08219700 chr8:58056026 NA 0.45 5.83 0.3 1.28e-8 Developmental language disorder (linguistic errors); LUSC cis rs2637266 0.777 rs1907302 chr10:78310828 T/C cg18941641 chr10:78392320 NA 0.35 6.19 0.32 1.75e-9 Pulmonary function; LUSC cis rs10751667 0.666 rs10902249 chr11:958566 C/T ch.11.42038R chr11:967971 AP2A2 -0.46 -6.96 -0.36 1.8e-11 Alzheimer's disease (late onset); LUSC cis rs9309473 1.000 rs13432605 chr2:73810981 C/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.6 -0.34 1.59e-10 Metabolite levels; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg24739457 chr1:205821442 NA 0.35 6.02 0.31 4.66e-9 Menarche (age at onset); LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg13047869 chr3:10149882 C3orf24 0.6 8.36 0.42 1.74e-15 Alzheimer's disease; LUSC cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg24692254 chr21:30365293 RNF160 -0.84 -15.34 -0.64 1.37e-40 Dental caries; LUSC cis rs7953249 0.807 rs2393775 chr12:121424574 G/A cg02403541 chr12:121454288 C12orf43 -0.62 -9.08 -0.44 9.97e-18 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC trans rs57046232 0.552 rs932828 chr20:6340080 G/A cg21095983 chr6:86352623 SYNCRIP 0.46 7.01 0.36 1.32e-11 Colorectal cancer; LUSC cis rs9325144 0.555 rs7968322 chr12:38792348 T/C cg13010199 chr12:38710504 ALG10B -0.5 -7.61 -0.38 2.86e-13 Morning vs. evening chronotype; LUSC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11890956 chr21:40555474 PSMG1 -0.85 -15.03 -0.64 2.4e-39 Cognitive function; LUSC cis rs2281845 0.929 rs6413915 chr1:201091041 A/C cg17810781 chr1:201082982 CACNA1S -0.35 -6.69 -0.34 9.47e-11 Permanent tooth development; LUSC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.55 0.46 2.98e-19 Eosinophil percentage of white cells; LUSC cis rs2073300 0.609 rs3827086 chr20:23357331 C/T cg12062639 chr20:23401060 NAPB 0.97 7.94 0.4 3.07e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4595586 0.545 rs2388174 chr12:39389237 G/A cg13010199 chr12:38710504 ALG10B 0.41 6.0 0.31 5.07e-9 Morning vs. evening chronotype; LUSC cis rs17125944 0.505 rs2274275 chr14:53235728 G/T cg13660082 chr14:53194042 PSMC6 -0.78 -6.81 -0.35 4.55e-11 Alzheimer's disease (late onset); LUSC cis rs7568458 0.663 rs699664 chr2:85780536 A/G cg02493740 chr2:85810744 VAMP5 0.55 10.26 0.49 1.23e-21 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.41 -0.46 8.25e-19 Chronic sinus infection; LUSC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg18252515 chr7:66147081 NA 1.24 14.21 0.61 3.56e-36 Diabetic kidney disease; LUSC cis rs10876993 0.855 rs1689601 chr12:58049557 G/A cg15848620 chr12:58087721 OS9 -0.52 -7.56 -0.38 3.89e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg12963246 chr6:28129442 ZNF389 0.49 6.74 0.35 6.8e-11 Depression; LUSC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.74e-12 Resting heart rate; LUSC cis rs11971779 0.680 rs6467846 chr7:139079385 G/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11644478 chr21:40555479 PSMG1 -0.95 -18.89 -0.72 1.23e-54 Cognitive function; LUSC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg22875332 chr1:76189707 ACADM 0.85 15.67 0.65 6.91e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.45 0.33 3.98e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11122272 0.735 rs2808583 chr1:231512587 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.87 -0.48 2.56e-20 Hemoglobin concentration; LUSC cis rs11190604 1.000 rs4919464 chr10:102221195 A/G cg07080220 chr10:102295463 HIF1AN 0.65 8.72 0.43 1.34e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg16049864 chr8:95962084 TP53INP1 -0.62 -11.6 -0.54 2.27e-26 Type 2 diabetes; LUSC cis rs6977660 0.714 rs34451907 chr7:19824538 A/G cg07541023 chr7:19748670 TWISTNB 0.6 6.3 0.33 9.49e-10 Thyroid stimulating hormone; LUSC cis rs1577917 0.727 rs9351065 chr6:86360428 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.94 -0.51 5.23e-24 Response to antipsychotic treatment; LUSC cis rs4474465 0.833 rs10793320 chr11:78217460 G/A cg27205649 chr11:78285834 NARS2 0.5 5.86 0.31 1.09e-8 Alzheimer's disease (survival time); LUSC cis rs10504073 0.584 rs62507177 chr8:49937306 C/A cg00325661 chr8:49890786 NA 0.7 11.14 0.52 1.01e-24 Blood metabolite ratios; LUSC cis rs7822232 1.000 rs7822232 chr8:145145687 A/C cg06495924 chr8:145149574 CYC1 -0.65 -5.86 -0.31 1.12e-8 Blood metabolite levels; LUSC cis rs668210 0.793 rs1192184 chr11:65773382 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 -0.59 -7.62 -0.38 2.73e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg13560548 chr3:10150139 C3orf24 0.54 7.37 0.37 1.33e-12 Alzheimer's disease; LUSC cis rs7568458 0.870 rs1972297 chr2:85808573 T/C cg17127132 chr2:85788382 GGCX 0.47 7.51 0.38 5.54e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg14830002 chr1:247616686 OR2B11 0.51 7.05 0.36 1.05e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs2348418 0.864 rs2175464 chr12:28717111 A/C cg13890972 chr12:28721907 NA 0.35 6.01 0.31 4.85e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg01097406 chr16:89675127 NA -0.34 -6.82 -0.35 4.39e-11 Vitiligo; LUSC cis rs12681288 0.550 rs76893867 chr8:962618 G/C cg04851639 chr8:1020857 NA -0.4 -8.05 -0.4 1.43e-14 Schizophrenia; LUSC cis rs11608355 1.000 rs7969719 chr12:109883577 C/T cg05360138 chr12:110035743 NA 0.45 6.31 0.33 8.73e-10 Neuroticism; LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 8.22e-43 Menopause (age at onset); LUSC cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg18876405 chr7:65276391 NA 0.55 8.81 0.43 7.07e-17 Aortic root size; LUSC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg20891283 chr12:69753455 YEATS4 0.93 17.84 0.7 1.8e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg06636001 chr8:8085503 FLJ10661 0.66 10.88 0.51 8.63e-24 Systolic blood pressure; LUSC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg04450456 chr4:17643702 FAM184B 0.35 5.81 0.3 1.47e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg22166914 chr1:53195759 ZYG11B 0.47 7.4 0.38 1.14e-12 Monocyte count; LUSC cis rs11229555 0.874 rs11229505 chr11:58274155 T/C cg15696309 chr11:58395628 NA -0.71 -8.98 -0.44 2.06e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs67340775 0.748 rs13212651 chr6:27806985 A/G cg01620082 chr3:125678407 NA -0.82 -7.24 -0.37 3.06e-12 Lung cancer in ever smokers; LUSC cis rs1559088 0.948 rs7247748 chr19:33594023 T/C cg17764715 chr19:33622953 WDR88 0.59 8.16 0.41 6.86e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.38 0.33 6e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg00484396 chr16:3507460 NAT15 0.5 8.17 0.41 6.47e-15 Body mass index (adult); LUSC cis rs4947962 0.585 rs17172435 chr7:55146471 C/T cg23757825 chr7:55092271 EGFR -0.46 -5.83 -0.3 1.34e-8 Subjective response to lithium treatment; LUSC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg12403142 chr1:92012408 NA -0.38 -6.17 -0.32 1.95e-9 Breast cancer; LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.08 -0.32 3.35e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04730029 chr22:42915845 RRP7A 0.39 5.99 0.31 5.48e-9 Triglycerides; LUSC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg09034736 chr1:150693464 HORMAD1 0.42 5.85 0.3 1.17e-8 Melanoma; LUSC cis rs4595586 0.545 rs1562729 chr12:39406179 T/G cg26384229 chr12:38710491 ALG10B 0.49 6.96 0.36 1.76e-11 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24398956 chr15:40331323 SRP14 -0.39 -5.99 -0.31 5.54e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11018904 0.906 rs17227345 chr11:89954685 A/T cg26028595 chr11:89956573 CHORDC1 0.5 5.81 0.3 1.42e-8 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.45 5.79 0.3 1.67e-8 Renal function-related traits (BUN); LUSC cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg14019146 chr3:50243930 SLC38A3 0.39 8.57 0.42 3.81e-16 Menarche (age at onset); LUSC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg24977027 chr2:88469347 THNSL2 -0.42 -6.56 -0.34 2.08e-10 Response to metformin (IC50); LUSC cis rs7615952 0.932 rs13086087 chr3:125646281 A/C cg05084668 chr3:125655381 ALG1L -0.79 -11.85 -0.54 2.72e-27 Blood pressure (smoking interaction); LUSC cis rs2236918 0.901 rs1776132 chr1:242024473 C/G cg17736920 chr1:242011382 EXO1 0.44 7.02 0.36 1.22e-11 Menopause (age at onset); LUSC cis rs748404 0.631 rs28702649 chr15:43648629 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.42 5.81 0.3 1.44e-8 Lung cancer; LUSC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.75 0.39 1.08e-13 Bipolar disorder; LUSC trans rs9372498 0.764 rs9489369 chr6:118720704 A/C cg07666134 chr16:1331609 NA -0.44 -6.13 -0.32 2.52e-9 Diastolic blood pressure; LUSC cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.63 10.13 0.48 3.24e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg04362960 chr10:104952993 NT5C2 0.57 8.99 0.44 1.92e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs61931739 0.500 rs3922568 chr12:34560107 A/C cg26384229 chr12:38710491 ALG10B 0.79 13.44 0.59 3.1e-33 Morning vs. evening chronotype; LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg06484146 chr7:12443880 VWDE -0.73 -7.29 -0.37 2.26e-12 Coronary artery disease; LUSC cis rs4964805 0.913 rs11111795 chr12:104204830 C/A cg02344784 chr12:104178138 NT5DC3 0.45 7.39 0.37 1.18e-12 Attention deficit hyperactivity disorder; LUSC cis rs7568458 0.684 rs1048739 chr2:85764968 T/G cg02493740 chr2:85810744 VAMP5 -0.53 -9.28 -0.45 2.2e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2050392 0.544 rs598672 chr10:30742388 C/T cg25182066 chr10:30743637 MAP3K8 -0.47 -6.7 -0.34 8.99e-11 Inflammatory bowel disease; LUSC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg05084668 chr3:125655381 ALG1L -0.51 -7.16 -0.36 5.26e-12 Blood pressure (smoking interaction); LUSC cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.35 -0.37 1.52e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 14.09 0.61 1.09e-35 Platelet count; LUSC cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -8.18 -0.41 6.2e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05808815 chr1:54666250 CYB5RL;MRPL37 -0.48 -6.13 -0.32 2.43e-9 Bipolar disorder and schizophrenia; LUSC cis rs116988415 0.584 rs2269305 chr14:65245650 C/G cg25083366 chr14:65239357 SPTB 0.58 6.12 0.32 2.67e-9 Daytime sleep phenotypes; LUSC cis rs9814567 0.964 rs6772406 chr3:134210183 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -14.04 -0.61 1.56e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 7.33 0.37 1.77e-12 Cerebrospinal P-tau181p levels; LUSC cis rs62400317 0.859 rs12205860 chr6:45157323 G/A cg18551225 chr6:44695536 NA -0.44 -7.2 -0.37 4.1e-12 Total body bone mineral density; LUSC cis rs9462027 0.561 rs2814972 chr6:34566975 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.17 -0.32 1.94e-9 Systemic lupus erythematosus; LUSC cis rs11098499 0.863 rs3775844 chr4:120428033 G/A cg24375607 chr4:120327624 NA 0.76 11.36 0.53 1.73e-25 Corneal astigmatism; LUSC cis rs8060686 0.545 rs12597573 chr16:68167521 A/C cg27539214 chr16:67997921 SLC12A4 0.61 7.4 0.38 1.09e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs6754311 0.731 rs3769005 chr2:136603366 C/G cg07169764 chr2:136633963 MCM6 -0.63 -8.46 -0.42 8.42e-16 Mosquito bite size; LUSC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg13531842 chr10:38383804 ZNF37A 0.43 6.68 0.34 9.87e-11 Extrinsic epigenetic age acceleration; LUSC cis rs3892630 0.824 rs34425841 chr19:33231619 C/T cg22980127 chr19:33182716 NUDT19 0.87 11.26 0.52 3.63e-25 Red blood cell traits; LUSC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg03452623 chr4:187889614 NA 0.88 17.68 0.7 7.91e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs62238980 0.614 rs116941748 chr22:32404361 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs1577917 0.771 rs2475791 chr6:86368164 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -8.59 -0.43 3.48e-16 Response to antipsychotic treatment; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14598950 chr3:37035355 MLH1;EPM2AIP1 0.4 6.53 0.34 2.39e-10 Triglycerides; LUSC cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -7.03 -0.36 1.2e-11 Monocyte percentage of white cells; LUSC cis rs921665 0.915 rs11127382 chr2:3185675 A/T cg16434511 chr2:3151078 NA -0.53 -6.35 -0.33 7.11e-10 World class endurance athleticism; LUSC cis rs9314614 0.933 rs2741098 chr8:6690276 C/T cg27319216 chr8:6693540 XKR5 0.31 5.77 0.3 1.85e-8 IgA nephropathy;White blood cell count (basophil); LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg11645453 chr3:52864694 ITIH4 -0.32 -7.43 -0.38 9.38e-13 Bipolar disorder; LUSC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg06618935 chr21:46677482 NA -0.4 -8.07 -0.4 1.32e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4906332 0.966 rs35799018 chr14:103893475 G/A cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.46e-12 Coronary artery disease; LUSC cis rs7582180 0.629 rs4850926 chr2:100954117 C/T cg12002119 chr2:101014098 CHST10 0.34 5.65 0.3 3.48e-8 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24061580 chr7:151573966 PRKAG2 0.46 6.6 0.34 1.63e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9905704 0.918 rs34430710 chr17:56876627 A/T cg12560992 chr17:57184187 TRIM37 0.57 7.9 0.4 4.02e-14 Testicular germ cell tumor; LUSC cis rs4964805 1.000 rs4964794 chr12:104194418 T/C cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC cis rs10740039 0.883 rs7097818 chr10:62394864 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg00012203 chr2:219082015 ARPC2 0.7 11.63 0.54 1.73e-26 Colorectal cancer; LUSC cis rs4268898 0.965 rs13033241 chr2:24476118 G/C cg06627628 chr2:24431161 ITSN2 0.62 9.14 0.45 6.05e-18 Asthma; LUSC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg15147215 chr3:52552868 STAB1 -0.31 -6.2 -0.32 1.65e-9 Bipolar disorder; LUSC cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg11494091 chr17:61959527 GH2 -0.62 -13.07 -0.58 8.41e-32 Prudent dietary pattern; LUSC cis rs7824557 0.545 rs2572380 chr8:11237477 A/G cg21775007 chr8:11205619 TDH -0.65 -10.26 -0.49 1.22e-21 Retinal vascular caliber; LUSC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg11764359 chr7:65958608 NA -0.51 -6.23 -0.32 1.44e-9 Aortic root size; LUSC trans rs1005277 0.579 rs176880 chr10:38401417 C/G cg17830980 chr10:43048298 ZNF37B 0.59 9.52 0.46 3.53e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7618501 1.000 rs7634902 chr3:49762662 G/T cg24110177 chr3:50126178 RBM5 0.43 6.78 0.35 5.49e-11 Intelligence (multi-trait analysis); LUSC cis rs727505 0.721 rs11536526 chr7:124749441 G/A cg23710748 chr7:124431027 NA -0.4 -7.08 -0.36 8.69e-12 Lewy body disease; LUSC cis rs894734 0.535 rs2366144 chr12:54324069 G/T cg25024717 chr12:54324583 NA -0.39 -6.84 -0.35 3.88e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs34734847 1.000 rs35360964 chr12:121156290 T/C cg21892295 chr12:121157589 UNC119B -0.52 -9.54 -0.46 3.07e-19 Mean corpuscular volume; LUSC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.49 -0.38 6.15e-13 Aortic root size; LUSC trans rs9747201 0.962 rs11656153 chr17:80072950 G/A cg07393940 chr7:158741817 NA -0.56 -8.53 -0.42 5.23e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg16606324 chr3:10149918 C3orf24 0.64 9.39 0.46 9.87e-19 Alzheimer's disease; LUSC cis rs9527 0.590 rs943039 chr10:104825132 C/T cg04362960 chr10:104952993 NT5C2 0.62 9.62 0.47 1.71e-19 Arsenic metabolism; LUSC cis rs7172677 0.768 rs72730586 chr15:75354165 G/A cg14664628 chr15:75095509 CSK 0.47 6.13 0.32 2.5e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs12190007 0.547 rs2981944 chr6:169801753 T/G cg15038512 chr6:170123185 PHF10 -0.38 -6.14 -0.32 2.34e-9 Obesity-related traits; LUSC cis rs7412746 0.566 rs11204743 chr1:150890406 A/T cg22823121 chr1:150693482 HORMAD1 0.47 6.47 0.33 3.59e-10 Melanoma; LUSC cis rs11039100 0.850 rs11039116 chr11:5831551 T/A cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg03929089 chr4:120376271 NA -0.85 -11.65 -0.54 1.45e-26 Coronary artery disease; LUSC cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg12935359 chr14:103987150 CKB -0.52 -7.95 -0.4 2.93e-14 Bone mineral density; LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 14.23 0.61 3.08e-36 Platelet count; LUSC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.87 0.31 1.03e-8 Intelligence (multi-trait analysis); LUSC trans rs4729127 1.000 rs8180725 chr7:94010953 G/C cg14660007 chr13:78271894 SLAIN1 0.49 6.23 0.32 1.39e-9 Intelligence; LUSC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.77 13.49 0.59 2.06e-33 Menarche (age at onset); LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg16647868 chr5:131706066 SLC22A5 0.39 6.04 0.31 4.05e-9 Blood metabolite levels; LUSC cis rs10746514 0.786 rs9308486 chr1:232246418 A/G cg09506761 chr1:232265262 NA 0.51 8.24 0.41 3.92e-15 Response to statin therapy; LUSC cis rs61931739 0.534 rs7133262 chr12:34279444 G/A cg06521331 chr12:34319734 NA -0.47 -7.81 -0.39 7.42e-14 Morning vs. evening chronotype; LUSC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg10792982 chr14:105748885 BRF1 0.48 8.81 0.43 7.05e-17 Mean platelet volume;Platelet distribution width; LUSC trans rs61931739 0.500 rs11053222 chr12:34481100 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.7 0.65 5.49e-42 Morning vs. evening chronotype; LUSC cis rs7493 0.901 rs17882539 chr7:95026408 G/A cg17330251 chr7:94953956 PON1 -0.35 -5.74 -0.3 2.08e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg26752657 chr1:75199075 CRYZ;TYW3 0.4 6.05 0.31 3.79e-9 Resistin levels; LUSC cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg05283184 chr6:79620031 NA -0.45 -8.44 -0.42 9.95e-16 Intelligence (multi-trait analysis); LUSC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg09904177 chr6:26538194 HMGN4 0.42 6.14 0.32 2.41e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg18876405 chr7:65276391 NA 0.67 11.74 0.54 7.23e-27 Aortic root size; LUSC cis rs7267979 0.789 rs62213729 chr20:25363426 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.76 -15.39 -0.64 9.26e-41 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11122272 0.735 rs2491404 chr1:231512127 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg05373962 chr22:49881684 NA -0.44 -10.74 -0.51 2.5e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg23758822 chr17:41437982 NA 1.03 19.75 0.73 4.62e-58 Menopause (age at onset); LUSC cis rs11098499 0.874 rs13139045 chr4:120168588 T/C cg09307838 chr4:120376055 NA 0.63 9.31 0.45 1.77e-18 Corneal astigmatism; LUSC cis rs1953600 0.837 rs2236556 chr10:81932790 T/C cg00277334 chr10:82204260 NA 0.45 7.0 0.36 1.37e-11 Sarcoidosis; LUSC cis rs7507204 0.767 rs12982509 chr19:3412057 C/T cg08380311 chr19:3435252 NFIC -0.69 -9.71 -0.47 8.67e-20 Height; LUSC trans rs11098499 0.913 rs35271032 chr4:120156659 C/T cg25214090 chr10:38739885 LOC399744 0.45 6.6 0.34 1.61e-10 Corneal astigmatism; LUSC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.44 -8.02 -0.4 1.75e-14 Monocyte percentage of white cells; LUSC cis rs77106637 0.556 rs7123876 chr11:72444583 T/C cg04827223 chr11:72435913 ARAP1 -0.86 -14.52 -0.62 2.24e-37 Type 2 diabetes; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.67 -11.13 -0.52 1.07e-24 Prudent dietary pattern; LUSC cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.43 -0.46 6.97e-19 Chronic sinus infection; LUSC cis rs12681287 0.640 rs13253296 chr8:87448245 C/T cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg15445000 chr17:37608096 MED1 0.38 6.4 0.33 5.21e-10 Glomerular filtration rate (creatinine); LUSC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg24733560 chr20:60626293 TAF4 0.39 6.4 0.33 5.13e-10 Body mass index; LUSC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.510 rs6587724 chr1:153034501 T/A cg00922841 chr1:152955080 SPRR1A -0.37 -6.16 -0.32 2.05e-9 Inflammatory skin disease; LUSC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg13877915 chr19:58951672 ZNF132 0.48 7.48 0.38 6.8e-13 Uric acid clearance; LUSC cis rs9393777 0.588 rs6926677 chr6:26478825 G/C cg12826209 chr6:26865740 GUSBL1 0.65 7.55 0.38 4.31e-13 Intelligence (multi-trait analysis); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg04100463 chr1:3540901 TPRG1L 0.41 6.03 0.31 4.31e-9 Mosquito bite size; LUSC cis rs314370 1.000 rs314370 chr7:100453208 T/C cg18683606 chr7:100471612 SRRT 0.44 5.86 0.31 1.13e-8 Resting heart rate; LUSC trans rs4596713 0.538 rs11145460 chr9:71766091 T/G cg25283916 chr1:242222868 NA -0.31 -6.44 -0.33 4.09e-10 Headache; LUSC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg21856205 chr7:94953877 PON1 -0.36 -5.73 -0.3 2.29e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC trans rs17039065 1.000 rs76088375 chr4:109393181 C/T cg07444054 chr2:108107501 NA 0.44 6.43 0.33 4.35e-10 Gut microbiome composition (summer); LUSC cis rs1728785 1.000 rs1728801 chr16:68571457 A/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg05528280 chr10:464225 DIP2C -0.41 -6.17 -0.32 1.99e-9 Psychosis in Alzheimer's disease; LUSC cis rs1577917 1.000 rs10944170 chr6:86685469 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.49 -0.42 6.7e-16 Response to antipsychotic treatment; LUSC trans rs853679 0.607 rs34788973 chr6:27879200 C/A cg01620082 chr3:125678407 NA -0.83 -7.18 -0.37 4.64e-12 Depression; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04567173 chr4:25379221 ANAPC4 -0.49 -6.5 -0.34 2.85e-10 Bipolar disorder and schizophrenia; LUSC trans rs7178375 1.000 rs9806159 chr15:31209654 G/T cg04373760 chr16:53404718 NA 0.61 8.66 0.43 2e-16 Hypertriglyceridemia; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg01266880 chr12:56552110 MYL6 0.42 5.97 0.31 6.1e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7246657 0.882 rs6508719 chr19:37877419 A/G cg23950597 chr19:37808831 NA -0.63 -7.63 -0.39 2.43e-13 Coronary artery calcification; LUSC trans rs11264213 0.901 rs72661616 chr1:36370512 G/A cg05872835 chr6:75796125 COL12A1 0.51 5.97 0.31 5.97e-9 Schizophrenia; LUSC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg19912559 chr1:40204330 PPIE 0.52 8.08 0.4 1.18e-14 Blood protein levels; LUSC cis rs6496667 0.683 rs1869180 chr15:90895467 T/C cg22089800 chr15:90895588 ZNF774 0.6 8.58 0.43 3.6e-16 Rheumatoid arthritis; LUSC cis rs7851660 0.844 rs993501 chr9:100623377 A/G cg13688889 chr9:100608707 NA 0.54 8.32 0.41 2.3e-15 Strep throat; LUSC cis rs10843647 1.000 rs4931279 chr12:30327704 C/A cg12718339 chr12:29936407 TMTC1 -0.35 -5.82 -0.3 1.41e-8 Glucose homeostasis traits; LUSC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg22437258 chr11:111473054 SIK2 -0.45 -6.03 -0.31 4.26e-9 Primary sclerosing cholangitis; LUSC cis rs6964587 0.869 rs6975243 chr7:91514672 G/A cg22709100 chr7:91322751 NA -0.4 -5.89 -0.31 9.18e-9 Breast cancer; LUSC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg21775007 chr8:11205619 TDH -0.44 -6.75 -0.35 6.57e-11 Neuroticism; LUSC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.44 -6.71 -0.34 8.59e-11 Mean platelet volume; LUSC cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.97 0.4 2.55e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg24675658 chr1:53192096 ZYG11B -0.65 -10.16 -0.49 2.65e-21 Monocyte count; LUSC trans rs804280 0.509 rs4841639 chr8:11796093 A/T cg14343924 chr8:8086146 FLJ10661 0.44 6.12 0.32 2.66e-9 Myopia (pathological); LUSC cis rs8017423 0.967 rs4904658 chr14:90721640 C/T cg14092571 chr14:90743983 NA -0.35 -5.83 -0.3 1.29e-8 Mortality in heart failure; LUSC cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.76 8.88 0.44 4.19e-17 Schizophrenia; LUSC cis rs7617773 0.817 rs6801801 chr3:48326433 T/C cg11946769 chr3:48343235 NME6 0.86 14.04 0.61 1.65e-35 Coronary artery disease; LUSC cis rs11828289 0.660 rs17306433 chr11:23223034 C/G cg20040320 chr11:23191996 NA -0.61 -6.3 -0.33 9.26e-10 Cancer; LUSC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg09455208 chr3:40491958 NA -0.54 -10.02 -0.48 7.77e-21 Renal cell carcinoma; LUSC cis rs8060686 0.516 rs8059575 chr16:68272635 C/G cg09835421 chr16:68378352 PRMT7 -0.51 -6.28 -0.32 1.06e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs12760731 0.720 rs10798606 chr1:178372965 G/A cg00404053 chr1:178313656 RASAL2 0.56 6.24 0.32 1.31e-9 Obesity-related traits; LUSC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.13e-16 Schizophrenia; LUSC cis rs7954584 0.551 rs1169072 chr12:122401501 C/T cg13699009 chr12:122356056 WDR66 -0.43 -6.6 -0.34 1.66e-10 Mean corpuscular volume; LUSC cis rs6665290 0.669 rs3768423 chr1:227177293 G/A cg10327440 chr1:227177885 CDC42BPA -1.11 -28.89 -0.85 7.41e-93 Myeloid white cell count; LUSC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg18681998 chr4:17616180 MED28 0.84 15.56 0.65 1.9e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17401966 0.540 rs58014725 chr1:10474457 T/A cg17425144 chr1:10567563 PEX14 -0.33 -5.75 -0.3 2.06e-8 Hepatocellular carcinoma; LUSC cis rs926392 0.965 rs6129168 chr20:37689360 T/C cg27552599 chr20:37590471 DHX35 0.34 5.95 0.31 6.89e-9 Dialysis-related mortality; LUSC cis rs8072100 0.713 rs4968257 chr17:45430534 A/G cg08085267 chr17:45401833 C17orf57 -0.51 -7.32 -0.37 1.9e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4665630 0.522 rs1862902 chr2:23886622 A/C cg08063864 chr2:24346004 PFN4;LOC375190 -0.72 -6.38 -0.33 5.98e-10 Hypertension; LUSC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg15921436 chr17:44337874 NA -0.7 -10.7 -0.51 3.72e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs727505 0.954 rs59379598 chr7:124596903 C/G cg23710748 chr7:124431027 NA -0.38 -6.63 -0.34 1.32e-10 Lewy body disease; LUSC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg07424592 chr7:64974309 NA 0.7 6.05 0.31 3.99e-9 Diabetic kidney disease; LUSC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg19346786 chr7:2764209 NA 0.49 8.21 0.41 4.8e-15 Height; LUSC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9611519 0.929 rs4820423 chr22:41430338 A/T cg13813247 chr22:41461852 NA -0.37 -6.73 -0.35 7.49e-11 Neuroticism; LUSC cis rs2011503 1.000 rs2011503 chr19:19443986 C/T cg11584989 chr19:19387371 SF4 0.61 7.35 0.37 1.54e-12 Bipolar disorder; LUSC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg08470875 chr2:26401718 FAM59B -0.65 -8.57 -0.42 3.91e-16 Gut microbiome composition (summer); LUSC cis rs3768617 0.740 rs28533496 chr1:183019885 G/T ch.1.3577855R chr1:183094577 LAMC1 0.59 8.5 0.42 6.29e-16 Fuchs's corneal dystrophy; LUSC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg13319975 chr6:146136371 FBXO30 -0.7 -10.88 -0.51 8.17e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs965469 1.000 rs2236108 chr20:3286331 A/C cg25506879 chr20:3388711 C20orf194 -0.52 -5.67 -0.3 3.07e-8 IFN-related cytopenia; LUSC cis rs11122272 0.735 rs2749707 chr1:231527316 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.86 -0.48 2.59e-20 Hemoglobin concentration; LUSC cis rs134594 1.000 rs134603 chr22:29473896 T/A cg03665785 chr22:29458676 C22orf31 0.28 5.75 0.3 2.04e-8 Birth weight; LUSC trans rs2898290 0.622 rs1600250 chr8:11345425 A/C cg06636001 chr8:8085503 FLJ10661 -0.55 -8.58 -0.42 3.56e-16 Systolic blood pressure; LUSC cis rs4588572 0.688 rs1594055 chr5:77695088 G/A cg11547950 chr5:77652471 NA -0.42 -6.56 -0.34 2.03e-10 Triglycerides; LUSC cis rs9300255 0.507 rs1727302 chr12:123632930 G/A cg06742321 chr12:123595122 PITPNM2 0.39 5.67 0.3 3.17e-8 Neutrophil percentage of white cells; LUSC cis rs7804356 1.000 rs3801807 chr7:26897439 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.23 -0.32 1.41e-9 Type 1 diabetes; LUSC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg26408565 chr15:76604113 ETFA -0.45 -7.02 -0.36 1.22e-11 Blood metabolite levels; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg05564831 chr3:52568323 NT5DC2 0.32 5.69 0.3 2.8e-8 Electroencephalogram traits; LUSC cis rs7264396 0.563 rs2425094 chr20:34306974 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.61 -0.43 2.97e-16 Total cholesterol levels; LUSC cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.36 5.96 0.31 6.55e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2204008 0.837 rs12370891 chr12:37984531 A/G cg06521331 chr12:34319734 NA -0.39 -5.98 -0.31 5.82e-9 Bladder cancer; LUSC cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg05347473 chr6:146136440 FBXO30 0.51 8.55 0.42 4.64e-16 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.534 rs11052973 chr12:34029708 A/G cg13010199 chr12:38710504 ALG10B 0.55 8.37 0.42 1.63e-15 Morning vs. evening chronotype; LUSC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg18230493 chr5:56204884 C5orf35 -0.57 -9.02 -0.44 1.51e-17 Coronary artery disease; LUSC cis rs11677416 1.000 rs6542094 chr2:113528625 A/G cg27083787 chr2:113543245 IL1A 0.44 6.97 0.36 1.65e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9473147 0.543 rs1004173 chr6:47445017 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.75 0.3 2.02e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg13939156 chr17:80058883 NA 0.33 6.5 0.34 2.87e-10 Life satisfaction; LUSC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs7071206 0.740 rs2048781 chr10:79422975 T/C cg07817648 chr10:79422355 NA -0.54 -7.35 -0.37 1.53e-12 Bone mineral density; LUSC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg06238570 chr21:40685208 BRWD1 0.47 7.29 0.37 2.25e-12 Cognitive function; LUSC cis rs950776 0.531 rs12915652 chr15:78831928 G/A cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs9788682 0.747 rs2656071 chr15:78745343 A/T cg24631222 chr15:78858424 CHRNA5 -0.66 -8.92 -0.44 3.17e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21659725 chr3:3221576 CRBN -0.87 -17.82 -0.7 2.21e-50 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.83 -0.54 3.32e-27 Chronic sinus infection; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg03395511 chr6:291903 DUSP22 -0.7 -11.51 -0.53 4.95e-26 Menopause (age at onset); LUSC cis rs1372520 0.684 rs2583978 chr4:90750326 A/C cg15133208 chr4:90757351 SNCA -0.53 -8.27 -0.41 3.2e-15 Neuroticism; LUSC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg18876405 chr7:65276391 NA -0.57 -9.18 -0.45 4.69e-18 Aortic root size; LUSC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.89 -0.31 9.29e-9 Major depressive disorder; LUSC cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg01884057 chr2:25150051 NA 0.47 10.88 0.51 8.51e-24 Body mass index; LUSC cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg01579765 chr21:45077557 HSF2BP -0.52 -11.13 -0.52 1.13e-24 Mean corpuscular volume; LUSC trans rs28647808 0.881 rs28625799 chr9:136264557 C/T cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg03909863 chr11:638404 DRD4 -0.41 -6.18 -0.32 1.84e-9 Systemic lupus erythematosus; LUSC cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg07606381 chr6:8435919 SLC35B3 0.72 11.88 0.55 2.09e-27 Motion sickness; LUSC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg16928487 chr17:17741425 SREBF1 0.37 7.11 0.36 7.27e-12 Total body bone mineral density; LUSC trans rs10435719 0.902 rs11250179 chr8:11800332 C/T cg08975724 chr8:8085496 FLJ10661 0.47 6.78 0.35 5.43e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2477686 0.526 rs12042427 chr1:2398107 C/T cg11214544 chr1:2391121 NA -0.61 -9.63 -0.47 1.54e-19 Non-obstructive azoospermia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22334543 chr19:3506226 FZR1 0.55 8.3 0.41 2.59e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.64 8.08 0.4 1.23e-14 Schizophrenia; LUSC cis rs3198697 1.000 rs3198697 chr16:15129940 C/T cg27102117 chr16:15229624 NA 0.35 6.04 0.31 4.17e-9 Triglycerides; LUSC cis rs9837602 1.000 rs34626154 chr3:99756312 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.43 -5.95 -0.31 6.87e-9 Breast cancer; LUSC cis rs6835098 0.692 rs7657374 chr4:174065756 A/T cg08422745 chr4:174089978 GALNT7 -0.53 -7.76 -0.39 1.01e-13 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs9807841 0.592 rs10419865 chr19:10772685 C/G cg09936142 chr19:10668400 KRI1 -0.4 -6.55 -0.34 2.15e-10 Inflammatory skin disease; LUSC cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.6 0.65 1.31e-41 Bladder cancer; LUSC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.63 -8.62 -0.43 2.78e-16 Multiple sclerosis; LUSC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18404041 chr3:52824283 ITIH1 -0.53 -10.2 -0.49 1.97e-21 Electroencephalogram traits; LUSC cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg05283184 chr6:79620031 NA -0.57 -11.96 -0.55 1.1e-27 Intelligence (multi-trait analysis); LUSC trans rs7824557 0.778 rs6601572 chr8:11093337 C/G cg08975724 chr8:8085496 FLJ10661 -0.46 -7.0 -0.36 1.42e-11 Retinal vascular caliber; LUSC cis rs748404 0.697 rs505249 chr15:43559960 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.2 0.41 5.14e-15 Lung cancer; LUSC cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.04 -0.36 1.11e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.754 rs1511025 chr4:120240238 T/C cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs7582180 0.663 rs10199518 chr2:100946041 G/A cg12002119 chr2:101014098 CHST10 0.36 5.96 0.31 6.51e-9 Intelligence (multi-trait analysis); LUSC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg11871910 chr12:69753446 YEATS4 -0.61 -8.03 -0.4 1.73e-14 Response to diuretic therapy; LUSC cis rs72634258 0.842 rs4908727 chr1:8163122 C/T cg00042356 chr1:8021962 PARK7 0.61 7.92 0.4 3.47e-14 Inflammatory bowel disease; LUSC cis rs8060686 0.545 rs9922165 chr16:68181177 C/A cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs929354 1.000 rs1182384 chr7:157040642 A/G cg05182265 chr7:156933206 UBE3C 0.48 7.32 0.37 1.91e-12 Body mass index; LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg00750074 chr16:89608354 SPG7 -0.45 -7.69 -0.39 1.66e-13 Multiple myeloma (IgH translocation); LUSC trans rs6933660 0.646 rs6915598 chr6:151778664 T/C cg09268963 chr14:64692302 SYNE2 0.45 6.17 0.32 1.92e-9 Menarche (age at onset); LUSC trans rs2204008 0.641 rs66876045 chr12:38205713 G/A cg06521331 chr12:34319734 NA -0.39 -6.12 -0.32 2.68e-9 Bladder cancer; LUSC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11644478 chr21:40555479 PSMG1 0.94 18.81 0.72 2.4e-54 Cognitive function; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs4144743 0.938 rs35069360 chr17:45321270 C/T cg18085866 chr17:45331354 ITGB3 -0.79 -8.33 -0.41 2.06e-15 Body mass index; LUSC cis rs10992471 0.603 rs12336884 chr9:95234183 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.68 -0.39 1.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs568617 0.626 rs78028320 chr11:65582015 G/A cg19792802 chr11:65647270 CTSW 0.44 6.21 0.32 1.56e-9 Crohn's disease; LUSC cis rs7113850 0.541 rs77699762 chr11:24236448 C/T ch.11.24196551F chr11:24239977 NA 1.0 9.04 0.44 1.31e-17 Bone fracture in osteoporosis; LUSC cis rs7267979 0.966 rs4815425 chr20:25398876 G/C cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg21918786 chr6:109611834 NA -0.42 -7.29 -0.37 2.33e-12 Reticulocyte fraction of red cells; LUSC cis rs1448094 0.802 rs11513957 chr12:86435551 C/T cg25456477 chr12:86230367 RASSF9 0.34 5.96 0.31 6.44e-9 Major depressive disorder; LUSC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.06 -0.31 3.72e-9 Total body bone mineral density; LUSC cis rs73206853 0.764 rs76142162 chr12:110884307 C/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs709400 0.859 rs942863 chr14:104021268 C/T cg12935359 chr14:103987150 CKB -0.4 -5.72 -0.3 2.38e-8 Body mass index; LUSC cis rs7647973 0.593 rs7620848 chr3:49828021 G/C cg13072238 chr3:49761600 GMPPB 0.65 8.33 0.41 2.14e-15 Menarche (age at onset); LUSC cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg26384229 chr12:38710491 ALG10B 0.93 15.89 0.66 9.63e-43 Bladder cancer; LUSC cis rs9653442 0.593 rs10865036 chr2:100860595 A/G cg22139774 chr2:100720529 AFF3 -0.39 -6.41 -0.33 4.94e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg18099408 chr3:52552593 STAB1 -0.41 -6.93 -0.35 2.12e-11 Bipolar disorder; LUSC cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg18904891 chr8:8559673 CLDN23 0.6 8.23 0.41 4.27e-15 Obesity-related traits; LUSC cis rs909341 0.629 rs3761124 chr20:62288752 T/C cg09650180 chr20:62225654 GMEB2 0.44 5.73 0.3 2.19e-8 Atopic dermatitis; LUSC cis rs2303282 0.717 rs11640819 chr16:56486248 A/G cg00500540 chr16:56394104 NA -0.43 -7.31 -0.37 1.93e-12 Breast cancer; LUSC cis rs7408868 0.831 rs7245850 chr19:15274585 A/C cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.15e-18 Pulse pressure; LUSC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.04 -0.4 1.57e-14 Neuroticism; LUSC cis rs4595586 0.525 rs6580891 chr12:39370127 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23100370 chr2:109336342 RANBP2 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs79387448 0.745 rs7575867 chr2:103120179 C/T cg09003973 chr2:102972529 NA 0.83 8.42 0.42 1.16e-15 Gut microbiota (bacterial taxa); LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg14092988 chr3:52407081 DNAH1 0.33 6.36 0.33 6.54e-10 Bipolar disorder; LUSC cis rs7833986 1.000 rs34952804 chr8:57097399 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.62 9.2 0.45 3.84e-18 Height; LUSC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg12365402 chr11:9010492 NRIP3 0.47 8.78 0.43 8.61e-17 Hemoglobin concentration; LUSC cis rs9341808 0.667 rs2490251 chr6:80895164 A/G cg08355045 chr6:80787529 NA 0.47 7.97 0.4 2.48e-14 Sitting height ratio; LUSC cis rs354225 0.584 rs6749802 chr2:54824146 A/G cg26097391 chr2:54893211 SPTBN1 0.44 6.62 0.34 1.41e-10 Schizophrenia; LUSC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg23625390 chr15:77176239 SCAPER 0.5 7.8 0.39 7.99e-14 Blood metabolite levels; LUSC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg23283495 chr1:209979779 IRF6 0.63 7.76 0.39 1.04e-13 Cleft lip with or without cleft palate; LUSC cis rs3741151 0.773 rs74881062 chr11:73245769 G/A cg17517138 chr11:73019481 ARHGEF17 0.97 8.13 0.41 8.58e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs546131 0.928 rs552868 chr11:34830694 G/A cg06937548 chr11:34938143 PDHX;APIP 0.47 6.68 0.34 9.73e-11 Lung disease severity in cystic fibrosis; LUSC cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg16322792 chr1:120165303 ZNF697 0.74 15.5 0.65 3.38e-41 Systemic lupus erythematosus; LUSC cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg22307029 chr19:49891270 CCDC155 -0.53 -7.18 -0.37 4.41e-12 Multiple sclerosis; LUSC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg08439880 chr3:133502540 NA -0.35 -6.36 -0.33 6.8e-10 Iron status biomarkers; LUSC cis rs4561483 0.624 rs2215928 chr16:11927918 A/T cg08843971 chr16:11963173 GSPT1 -0.39 -5.79 -0.3 1.65e-8 Testicular germ cell tumor; LUSC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg03929089 chr4:120376271 NA -0.94 -16.31 -0.67 2.11e-44 Height; LUSC trans rs6598955 0.627 rs3924324 chr1:26616280 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.86 -0.44 4.86e-17 Obesity-related traits; LUSC cis rs7267979 0.738 rs2892409 chr20:25638138 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.78 15.3 0.64 1.98e-40 Liver enzyme levels (alkaline phosphatase); LUSC trans rs961253 0.501 rs6054183 chr20:6354161 T/C cg21095983 chr6:86352623 SYNCRIP 0.49 7.37 0.37 1.37e-12 Colorectal cancer; LUSC cis rs11155671 0.530 rs6933882 chr6:150210802 A/G cg07701084 chr6:150067640 NUP43 0.46 6.93 0.35 2.23e-11 Testicular germ cell tumor; LUSC cis rs73198271 0.586 rs3789850 chr8:8686845 G/T cg01851573 chr8:8652454 MFHAS1 0.4 5.97 0.31 5.95e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg18876405 chr7:65276391 NA 0.54 8.27 0.41 3.22e-15 Aortic root size; LUSC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.53 0.59 1.52e-33 Total body bone mineral density; LUSC cis rs7605827 0.893 rs6733695 chr2:15525714 T/C cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg06634786 chr22:41940651 POLR3H -0.53 -6.47 -0.33 3.57e-10 Vitiligo; LUSC cis rs12618769 0.597 rs11884553 chr2:99131206 T/C cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs11997175 0.766 rs6983113 chr8:33699513 G/A ch.8.33884649F chr8:33765107 NA 0.37 5.82 0.3 1.36e-8 Body mass index; LUSC cis rs9633740 1.000 rs7900536 chr10:82253701 G/T cg01528321 chr10:82214614 TSPAN14 1.06 12.04 0.55 5.81e-28 Post bronchodilator FEV1; LUSC cis rs1729951 0.546 rs361246 chr3:136695667 G/A cg12473912 chr3:136751656 NA 0.39 6.82 0.35 4.16e-11 Neuroticism; LUSC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg26441486 chr22:50317300 CRELD2 -0.54 -8.25 -0.41 3.81e-15 Schizophrenia; LUSC cis rs2295359 0.892 rs2064689 chr1:67653010 G/A cg03340356 chr1:67600835 NA 0.42 6.6 0.34 1.57e-10 Psoriasis; LUSC cis rs60154123 0.730 rs10489391 chr1:210458861 C/T cg22029157 chr1:209979665 IRF6 -0.49 -5.72 -0.3 2.31e-8 Coronary artery disease; LUSC cis rs1568889 1.000 rs7933332 chr11:28036392 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.5 0.46 4.34e-19 Bipolar disorder; LUSC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs8014204 0.762 rs8016389 chr14:75287554 T/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.32 0.41 2.34e-15 Caffeine consumption; LUSC cis rs7193541 0.695 rs7199490 chr16:74716026 G/A cg01733217 chr16:74700730 RFWD3 0.81 12.41 0.56 2.46e-29 Multiple myeloma; LUSC cis rs7408868 0.764 rs12610803 chr19:15260682 A/C cg14696996 chr19:15285081 NOTCH3 0.97 8.71 0.43 1.48e-16 Pulse pressure; LUSC cis rs11031096 0.621 rs12282967 chr11:4191477 A/T cg18678763 chr11:4115507 RRM1 -0.41 -5.76 -0.3 1.96e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs61931739 0.517 rs4931748 chr12:34140827 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.54 0.42 4.86e-16 Morning vs. evening chronotype; LUSC cis rs668210 0.793 rs590531 chr11:65773939 C/A cg04700828 chr11:65773979 NA 0.4 5.72 0.3 2.35e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs6961069 0.868 rs1194177 chr7:80235095 A/G cg04458919 chr7:80252533 CD36 -0.36 -6.59 -0.34 1.75e-10 Platelet count; LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg10802521 chr3:52805072 NEK4 -0.55 -8.77 -0.43 9.4e-17 Bipolar disorder; LUSC cis rs30380 0.586 rs28119 chr5:96131733 G/A cg16492584 chr5:96139282 ERAP1 -0.56 -7.56 -0.38 3.94e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11890956 chr21:40555474 PSMG1 -0.92 -16.68 -0.67 7.22e-46 Cognitive function; LUSC cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.11e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs2275620 1.000 rs1891071 chr10:96805371 C/T cg09036531 chr10:96991505 NA -0.39 -5.68 -0.3 2.95e-8 Gout; LUSC trans rs2487048 0.725 rs2422493 chr9:107690995 G/A cg17444859 chr7:41543664 NA 0.27 6.3 0.33 9.61e-10 Intraocular pressure; LUSC cis rs3750965 0.959 rs3168115 chr11:68858090 A/T cg06818126 chr11:68850279 TPCN2 0.42 6.22 0.32 1.49e-9 Hair color; LUSC cis rs6599077 1.000 rs7637811 chr3:40096412 C/G cg13683864 chr3:40499215 RPL14 -0.6 -7.66 -0.39 2.06e-13 Sleep-related phenotypes; LUSC cis rs78545713 0.649 rs79759076 chr6:26223694 C/G cg23601095 chr6:26197514 HIST1H3D 0.64 5.76 0.3 1.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg20573242 chr4:122745356 CCNA2 0.64 9.03 0.44 1.36e-17 Type 2 diabetes; LUSC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg12826209 chr6:26865740 GUSBL1 0.76 9.18 0.45 4.6e-18 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.3e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg25258033 chr6:167368657 RNASET2 0.39 6.3 0.33 9.49e-10 Crohn's disease; LUSC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg15744005 chr10:104629667 AS3MT -0.29 -6.33 -0.33 7.86e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg13535736 chr9:111863775 C9orf5 -0.38 -6.11 -0.32 2.71e-9 Menarche (age at onset); LUSC cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg19875535 chr5:140030758 IK -0.53 -8.69 -0.43 1.67e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs7296418 0.699 rs11608297 chr12:123826642 T/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.12 -0.41 9.24e-15 Platelet count; LUSC cis rs9948 0.655 rs62156228 chr2:97420335 A/G cg01990225 chr2:97406019 LMAN2L -1.06 -7.21 -0.37 3.87e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs7909074 0.831 rs2065466 chr10:45384047 T/C cg04218760 chr10:45406644 TMEM72 -0.28 -6.85 -0.35 3.52e-11 Mean corpuscular volume; LUSC cis rs10832963 1.000 rs4757676 chr11:18640477 C/T cg09201001 chr11:18656081 SPTY2D1 0.94 15.29 0.64 2.25e-40 Breast cancer; LUSC cis rs6430585 0.583 rs58509842 chr2:136586027 G/A cg07169764 chr2:136633963 MCM6 1.16 17.45 0.69 6.42e-49 Corneal structure; LUSC cis rs3101457 0.530 rs9782996 chr1:244528127 C/T cg09033006 chr1:244517177 C1orf100 0.39 5.72 0.3 2.38e-8 Smoking behavior; LUSC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 5.89 0.31 9.6e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs983392 0.679 rs655231 chr11:60013857 A/G cg02771260 chr11:59836817 MS4A3 -0.37 -6.11 -0.32 2.79e-9 Alzheimer's disease (late onset); LUSC cis rs9467773 0.595 rs2172007 chr6:26639777 A/C cg05738196 chr6:26577821 NA 0.78 14.76 0.63 2.72e-38 Intelligence (multi-trait analysis); LUSC cis rs2235649 0.828 rs9936486 chr16:1849888 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.11 -0.32 2.71e-9 Blood metabolite levels; LUSC cis rs1008375 0.966 rs6449325 chr4:17699509 C/T cg18681998 chr4:17616180 MED28 -0.74 -12.53 -0.57 8.96e-30 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1448094 0.872 rs7305869 chr12:86440114 A/G cg00310523 chr12:86230176 RASSF9 0.36 6.56 0.34 2.08e-10 Major depressive disorder; LUSC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg03609598 chr5:56110824 MAP3K1 -0.42 -6.24 -0.32 1.33e-9 Initial pursuit acceleration; LUSC cis rs9905704 0.918 rs2611779 chr17:56791832 A/G cg12560992 chr17:57184187 TRIM37 0.54 7.75 0.39 1.15e-13 Testicular germ cell tumor; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23041332 chr4:185395887 IRF2 -0.44 -6.61 -0.34 1.54e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11585357 0.895 rs72633814 chr1:17626456 T/C cg08277548 chr1:17600880 PADI3 -0.58 -5.9 -0.31 8.89e-9 Hair shape; LUSC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg12963246 chr6:28129442 ZNF389 0.49 7.19 0.37 4.21e-12 Parkinson's disease; LUSC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg17143192 chr8:8559678 CLDN23 0.59 8.48 0.42 7.54e-16 Obesity-related traits; LUSC cis rs2124969 0.548 rs62175388 chr2:161019664 G/A cg03641300 chr2:160917029 PLA2R1 -0.47 -5.7 -0.3 2.7e-8 Waist circumference adjusted for body mass index; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.77 0.51 2e-23 Alzheimer's disease; LUSC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg03351412 chr1:154909251 PMVK 0.55 8.85 0.44 5.3e-17 Prostate cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04860157 chr6:36842651 PPIL1 0.42 5.98 0.31 5.77e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10744422 1.000 rs10744422 chr12:123336789 T/C cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.08e-12 Schizophrenia; LUSC cis rs11690935 0.589 rs62183782 chr2:172865009 T/A cg13550731 chr2:172543902 DYNC1I2 0.53 7.98 0.4 2.31e-14 Schizophrenia; LUSC cis rs7809950 0.817 rs2222845 chr7:107281829 C/T cg23024343 chr7:107201750 COG5 0.64 9.36 0.46 1.23e-18 Coronary artery disease; LUSC cis rs2046867 0.818 rs11928620 chr3:72863209 A/C cg04365224 chr3:72788183 NA -0.46 -5.72 -0.3 2.41e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs34172651 0.917 rs8043962 chr16:24781372 A/G cg00339695 chr16:24857497 SLC5A11 0.37 6.56 0.34 1.99e-10 Intelligence (multi-trait analysis); LUSC cis rs2841277 0.646 rs2819419 chr14:105406238 A/C cg17340268 chr14:105411764 AHNAK2 -0.38 -6.02 -0.31 4.47e-9 Rheumatoid arthritis; LUSC cis rs11971779 0.680 rs3924296 chr7:139041927 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs5771225 0.544 rs1555048 chr22:50688348 A/G cg16473166 chr22:50639996 SELO 0.59 7.76 0.39 1.03e-13 Late-onset Alzheimer's disease; LUSC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg14789911 chr21:47582049 C21orf56 -0.36 -5.69 -0.3 2.76e-8 Testicular germ cell tumor; LUSC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg19748678 chr4:122722346 EXOSC9 0.7 10.61 0.5 7.26e-23 Type 2 diabetes; LUSC cis rs28655083 0.913 rs7190129 chr16:77071456 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.38 -5.68 -0.3 2.9e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs4400599 0.618 rs1194603 chr1:154228287 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 0.34 5.66 0.3 3.22e-8 Platelet distribution width; LUSC cis rs7539409 0.604 rs910183 chr1:84297285 A/G cg10977910 chr1:84465055 TTLL7 0.67 7.1 0.36 7.44e-12 Alzheimer's disease; LUSC cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 12.57 0.57 6.34e-30 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2637266 0.626 rs846617 chr10:78546881 A/G cg18941641 chr10:78392320 NA 0.4 7.25 0.37 2.87e-12 Pulmonary function; LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg20887711 chr4:1340912 KIAA1530 -0.65 -9.97 -0.48 1.12e-20 Obesity-related traits; LUSC cis rs1670533 1.000 rs7669399 chr4:1058478 T/G cg27284194 chr4:1044797 NA 0.6 8.84 0.44 5.8e-17 Recombination rate (females); LUSC cis rs55665837 0.539 rs10766196 chr11:14913131 A/G cg19336497 chr11:14380999 RRAS2 -0.33 -5.92 -0.31 7.78e-9 Vitamin D levels; LUSC cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg05347473 chr6:146136440 FBXO30 0.51 8.55 0.42 4.64e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs11676348 0.818 rs6436033 chr2:218983763 A/G cg00012203 chr2:219082015 ARPC2 -0.58 -9.23 -0.45 3.29e-18 Ulcerative colitis; LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg05896524 chr21:47604654 C21orf56 0.5 7.79 0.39 8.68e-14 Testicular germ cell tumor; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.53 -8.13 -0.41 8.36e-15 Lymphocyte counts; LUSC cis rs10876993 0.715 rs2169987 chr12:58012111 G/A cg15848620 chr12:58087721 OS9 0.46 6.4 0.33 5.36e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.13 0.41 8.34e-15 Axial length; LUSC cis rs6582630 0.573 rs12319414 chr12:38267440 T/C cg26384229 chr12:38710491 ALG10B -0.57 -8.51 -0.42 5.99e-16 Drug-induced liver injury (flucloxacillin); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg10339542 chr17:10600919 C17orf48;SCO1 0.36 6.36 0.33 6.61e-10 Metabolite levels (Pyroglutamine); LUSC cis rs4363385 0.747 rs11205151 chr1:152961496 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.64 -0.39 2.3e-13 Inflammatory skin disease; LUSC cis rs6120849 0.754 rs3746446 chr20:33574765 T/C cg24642439 chr20:33292090 TP53INP2 0.61 6.68 0.34 1.01e-10 Protein C levels; LUSC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg13319975 chr6:146136371 FBXO30 0.7 11.08 0.52 1.65e-24 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11668770 chr19:56125740 NA 0.45 6.0 0.31 5.18e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg00814883 chr7:100076585 TSC22D4 -0.74 -9.47 -0.46 5.29e-19 Platelet count; LUSC trans rs61931739 0.500 rs7489270 chr12:34432062 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.63 0.65 9.84e-42 Morning vs. evening chronotype; LUSC cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg09517075 chr8:22133004 PIWIL2 0.43 8.54 0.42 4.89e-16 Hypertriglyceridemia; LUSC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.64 -0.57 3.31e-30 Platelet count; LUSC cis rs7224314 1.000 rs8070689 chr17:65387405 G/T cg01507342 chr17:65387096 PITPNC1 -0.44 -7.79 -0.39 8.5e-14 Diisocyanate-induced asthma; LUSC cis rs7666738 0.546 rs1456207 chr4:98676911 G/A cg03676636 chr4:99064102 C4orf37 0.31 6.13 0.32 2.47e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg00024416 chr22:24240387 NA -0.37 -6.45 -0.33 4.03e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg21681030 chr2:46777652 RHOQ 0.44 6.3 0.33 9.63e-10 Height; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg26338869 chr17:61819248 STRADA 0.42 5.96 0.31 6.57e-9 Prudent dietary pattern; LUSC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg02825527 chr7:2087843 MAD1L1 -0.5 -5.73 -0.3 2.29e-8 Bipolar disorder; LUSC cis rs12493885 0.585 rs787812 chr3:153622217 A/G cg17054900 chr3:154042577 DHX36 0.59 6.17 0.32 2e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs3733585 0.660 rs13122290 chr4:9933832 A/G cg26043149 chr18:55253948 FECH -0.45 -6.94 -0.36 2.01e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6582630 0.599 rs1851114 chr12:38424671 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.6 -0.34 1.63e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg24733560 chr20:60626293 TAF4 0.45 8.31 0.41 2.47e-15 Body mass index; LUSC trans rs11088226 0.581 rs2236430 chr21:33973408 A/G cg09050820 chr6:167586206 TCP10L2 -0.54 -8.66 -0.43 2.05e-16 Gastritis; LUSC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg20821713 chr7:1055600 C7orf50 -0.56 -7.36 -0.37 1.42e-12 Bronchopulmonary dysplasia; LUSC cis rs34779708 0.966 rs17591163 chr10:35465279 G/C cg03585969 chr10:35415529 CREM 0.62 9.05 0.44 1.23e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs11098499 0.863 rs6835635 chr4:120458867 A/G cg25214090 chr10:38739885 LOC399744 0.51 7.79 0.39 8.53e-14 Corneal astigmatism; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg21403912 chr1:155239301 CLK2 -0.41 -6.66 -0.34 1.13e-10 Educational attainment (years of education); LUSC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg12560992 chr17:57184187 TRIM37 0.84 15.11 0.64 1.16e-39 Intelligence (multi-trait analysis); LUSC cis rs10875595 0.836 rs1363450 chr5:140658363 A/T cg24830062 chr5:140700576 TAF7 0.48 6.09 0.32 3.18e-9 Pulmonary function decline; LUSC cis rs7674212 1.000 rs7674212 chr4:103988899 G/T cg16532752 chr4:104119610 CENPE -0.43 -6.34 -0.33 7.51e-10 Type 2 diabetes; LUSC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg08847533 chr14:75593920 NEK9 -0.86 -16.16 -0.66 8.43e-44 Height; LUSC trans rs28735056 1.000 rs56376220 chr18:77609462 C/T cg03973167 chr4:185394988 IRF2 0.43 6.07 0.32 3.49e-9 Schizophrenia; LUSC cis rs9467773 0.620 rs4368798 chr6:26593471 A/G cg05738196 chr6:26577821 NA 0.8 15.3 0.64 2.07e-40 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.514 rs2976926 chr8:8261624 T/C cg08975724 chr8:8085496 FLJ10661 0.51 7.98 0.4 2.29e-14 Mood instability; LUSC trans rs703108 0.869 rs12767559 chr10:22469145 A/G cg15415259 chr6:134158982 MGC34034 0.4 5.97 0.31 5.91e-9 Monocyte percentage of white cells; LUSC cis rs11690935 0.851 rs9808259 chr2:172648974 C/T cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.86 -0.63 1.03e-38 Schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24808674 chr1:51702659 RNF11 -0.46 -6.2 -0.32 1.7e-9 Hepatitis; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06666157 chr19:4791552 FEM1A 0.42 6.13 0.32 2.49e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg08999081 chr20:33150536 PIGU -0.39 -7.12 -0.36 6.76e-12 Height; LUSC cis rs7085104 0.513 rs619824 chr10:104581288 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.4 -5.86 -0.31 1.09e-8 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23359048 chr12:2921757 ITFG2 0.43 6.35 0.33 6.88e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4242434 0.819 rs6558167 chr8:22473850 T/C cg03733263 chr8:22462867 KIAA1967 0.89 15.58 0.65 1.59e-41 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg06634786 chr22:41940651 POLR3H 0.51 6.1 0.32 2.91e-9 Vitiligo; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg05863683 chr7:1912471 MAD1L1 0.3 5.87 0.31 1.07e-8 Bipolar disorder and schizophrenia; LUSC cis rs300703 0.719 rs400040 chr2:199422 G/T cg21211680 chr2:198530 NA 0.66 7.45 0.38 7.91e-13 Blood protein levels; LUSC cis rs10450586 0.932 rs10082611 chr11:27320108 C/G cg08958251 chr11:27270390 NA 0.33 5.65 0.3 3.47e-8 Total body bone mineral density; LUSC cis rs854765 0.583 rs66531105 chr17:17809001 C/T cg04398451 chr17:18023971 MYO15A -0.46 -7.3 -0.37 2.13e-12 Total body bone mineral density; LUSC trans rs11098499 0.754 rs12510269 chr4:120241646 A/G cg25214090 chr10:38739885 LOC399744 0.44 6.57 0.34 1.9e-10 Corneal astigmatism; LUSC trans rs67340775 0.834 rs13218875 chr6:27884012 C/T cg06606381 chr12:133084897 FBRSL1 -0.98 -8.54 -0.42 4.67e-16 Lung cancer in ever smokers; LUSC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg15485101 chr11:133734466 NA 0.4 7.23 0.37 3.23e-12 Childhood ear infection; LUSC cis rs2732480 0.500 rs2450991 chr12:48651621 A/G cg04545296 chr12:48745243 ZNF641 0.33 6.04 0.31 4.14e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4889855 0.545 rs61171555 chr17:78465975 T/G cg00066239 chr17:78472159 NA -0.42 -7.28 -0.37 2.46e-12 Fractional excretion of uric acid; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg12379764 chr21:47803548 PCNT 0.49 7.0 0.36 1.4e-11 Testicular germ cell tumor; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg02951883 chr7:2050386 MAD1L1 -0.65 -12.72 -0.57 1.7e-30 Bipolar disorder and schizophrenia; LUSC cis rs10876993 0.893 rs1678504 chr12:58085498 G/C cg15848620 chr12:58087721 OS9 -0.57 -8.14 -0.41 8.09e-15 Celiac disease or Rheumatoid arthritis; LUSC trans rs7916697 0.520 rs12265247 chr10:70038398 A/G cg04882175 chr6:131122610 NA -0.56 -7.63 -0.39 2.49e-13 Optic disc area; LUSC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); LUSC cis rs7804356 1.000 rs73067435 chr7:26850195 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs926938 0.527 rs6680112 chr1:115548915 G/C cg12756093 chr1:115239321 AMPD1 0.47 6.93 0.35 2.15e-11 Autism; LUSC cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg11266682 chr4:10021025 SLC2A9 0.45 8.29 0.41 2.86e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs13067593 1.000 rs73199038 chr3:188581584 G/A cg17809494 chr3:188572244 LPP 0.45 6.25 0.32 1.25e-9 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg23158103 chr7:148848205 ZNF398 -0.48 -7.84 -0.39 6.12e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg11752832 chr7:134001865 SLC35B4 0.59 9.3 0.45 1.94e-18 Mean platelet volume; LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg22535103 chr8:58192502 C8orf71 0.7 7.63 0.39 2.51e-13 Developmental language disorder (linguistic errors); LUSC cis rs57590327 0.503 rs1464790 chr3:81852923 A/T cg07356753 chr3:81810745 GBE1 0.63 10.09 0.48 4.41e-21 Extraversion; LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T cg19083779 chr1:57110724 PRKAA2 -0.37 -6.09 -0.32 3.11e-9 Leprosy; LUSC cis rs11122272 0.735 rs2486727 chr1:231539245 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.21 -0.49 1.82e-21 Hemoglobin concentration; LUSC cis rs4423214 0.959 rs11233747 chr11:71171642 G/A cg05163923 chr11:71159392 DHCR7 0.74 11.07 0.52 1.79e-24 Vitamin D levels; LUSC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg06022373 chr22:39101656 GTPBP1 0.78 12.2 0.56 1.47e-28 Menopause (age at onset); LUSC cis rs4566357 0.576 rs3769644 chr2:227917240 C/G cg11843606 chr2:227700838 RHBDD1 -0.53 -8.13 -0.41 8.48e-15 Coronary artery disease; LUSC trans rs61931739 0.635 rs1852224 chr12:33963080 A/C cg26384229 chr12:38710491 ALG10B 0.51 7.63 0.39 2.54e-13 Morning vs. evening chronotype; LUSC cis rs61931739 0.635 rs1486884 chr12:33908876 A/T cg06521331 chr12:34319734 NA 0.35 5.81 0.3 1.42e-8 Morning vs. evening chronotype; LUSC cis rs4629710 0.592 rs13206776 chr6:131576679 T/G cg12700074 chr6:131571435 AKAP7 -0.36 -5.92 -0.31 8.04e-9 Multiple myeloma (IgH translocation); LUSC trans rs61931739 0.500 rs34061369 chr12:34519283 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.57 0.65 1.71e-41 Morning vs. evening chronotype; LUSC cis rs9457247 0.765 rs9295385 chr6:167448181 A/G cg23791538 chr6:167370224 RNASET2 -0.41 -5.85 -0.3 1.19e-8 Crohn's disease; LUSC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.94 0.48 1.45e-20 Personality dimensions; LUSC cis rs2573652 0.722 rs11630930 chr15:100544145 G/T cg00587665 chr15:100533223 ADAMTS17 -0.38 -6.91 -0.35 2.44e-11 Height; LUSC cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg08999081 chr20:33150536 PIGU -0.54 -10.68 -0.5 4.35e-23 Glomerular filtration rate (creatinine); LUSC cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg15691649 chr6:25882328 NA 0.5 7.41 0.38 1.03e-12 Blood metabolite levels; LUSC cis rs59698941 0.943 rs57880964 chr5:132210674 G/C cg02081065 chr5:132209139 LEAP2 -0.66 -6.89 -0.35 2.8e-11 Apolipoprotein A-IV levels; LUSC cis rs57908212 1 rs57908212 chr19:2161321 T/C cg09261902 chr19:2140048 AP3D1 0.33 6.12 0.32 2.62e-9 Red blood cell count;Hemoglobin concentration;Hematocrit; LUSC cis rs7100689 0.646 rs9420370 chr10:82073248 C/T cg00277334 chr10:82204260 NA -0.59 -9.0 -0.44 1.78e-17 Post bronchodilator FEV1; LUSC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg10792982 chr14:105748885 BRF1 -0.52 -9.53 -0.46 3.28e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs9467773 0.620 rs1027203 chr6:26639332 G/C cg11502198 chr6:26597334 ABT1 0.69 11.45 0.53 7.68e-26 Intelligence (multi-trait analysis); LUSC trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg20290983 chr6:43655470 MRPS18A 0.88 13.23 0.59 1.98e-32 IgG glycosylation; LUSC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg17366294 chr4:99064904 C4orf37 0.57 9.73 0.47 7.43e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg00945038 chr17:61921165 SMARCD2 0.54 9.72 0.47 8.06e-20 Prudent dietary pattern; LUSC cis rs35491132 1 rs35491132 chr6:27527227 GT/G cg09904177 chr6:26538194 HMGN4 -0.76 -6.23 -0.32 1.43e-9 Urinary tract infection frequency; LUSC cis rs2625529 0.652 rs2957736 chr15:72265344 A/G cg16672083 chr15:72433130 SENP8 0.48 7.95 0.4 2.86e-14 Red blood cell count; LUSC cis rs2304069 0.954 rs2276983 chr5:149424966 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.69 9.72 0.47 8.13e-20 HIV-1 control; LUSC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22455342 chr2:225449267 CUL3 -0.78 -11.0 -0.52 3.18e-24 IgE levels in asthmatics (D.p. specific); LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.78 0.3 1.72e-8 Menopause (age at onset); LUSC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg17971929 chr21:40555470 PSMG1 -0.49 -7.22 -0.37 3.59e-12 Menarche (age at onset); LUSC cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.6 9.08 0.44 9.79e-18 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg08999081 chr20:33150536 PIGU 0.54 10.96 0.51 4.23e-24 Coronary artery disease; LUSC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.89 0.44 3.86e-17 Schizophrenia; LUSC cis rs9287719 0.967 rs9287720 chr2:10752664 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg07061783 chr6:25882402 NA -0.38 -5.86 -0.31 1.08e-8 Blood metabolite levels; LUSC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg10621924 chr7:39171070 POU6F2 0.48 7.58 0.38 3.36e-13 IgG glycosylation; LUSC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg08847533 chr14:75593920 NEK9 -0.81 -14.02 -0.61 2.01e-35 Height; LUSC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg21782813 chr7:2030301 MAD1L1 0.49 8.22 0.41 4.52e-15 Bipolar disorder and schizophrenia; LUSC cis rs240768 0.826 rs75352517 chr6:101085728 G/A cg12253828 chr6:101329408 ASCC3 0.87 5.95 0.31 6.66e-9 Economic and political preferences (immigration/crime); LUSC cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg15691649 chr6:25882328 NA -0.38 -6.22 -0.32 1.49e-9 Blood metabolite levels; LUSC cis rs9788682 0.948 rs34664138 chr15:78831624 T/G cg18825076 chr15:78729989 IREB2 0.47 6.28 0.32 1.07e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg27129171 chr3:47204927 SETD2 0.74 12.95 0.58 2.37e-31 Colorectal cancer; LUSC cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg27446573 chr6:127587934 RNF146 0.92 15.32 0.64 1.7e-40 Breast cancer; LUSC cis rs534126 1.000 rs534126 chr7:142921234 C/T cg04039957 chr7:143013207 CLCN1 0.31 5.94 0.31 7.14e-9 Cancer; LUSC cis rs6977660 0.619 rs10263780 chr7:19778086 A/G cg05791153 chr7:19748676 TWISTNB -0.72 -7.82 -0.39 7.14e-14 Thyroid stimulating hormone; LUSC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg12463550 chr7:65579703 CRCP 0.41 5.66 0.3 3.21e-8 Calcium levels; LUSC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7582180 0.764 rs10180423 chr2:100919012 C/G cg12002119 chr2:101014098 CHST10 0.36 6.11 0.32 2.83e-9 Intelligence (multi-trait analysis); LUSC cis rs7172677 0.960 rs1602360 chr15:75420761 G/A cg14664628 chr15:75095509 CSK -0.43 -5.72 -0.3 2.41e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11792861 0.926 rs12686736 chr9:111888739 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 9.05 0.44 1.2e-17 Menarche (age at onset); LUSC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg23649088 chr2:200775458 C2orf69 0.55 7.39 0.38 1.15e-12 Schizophrenia; LUSC cis rs9325144 0.560 rs6582539 chr12:38630097 C/T cg26384229 chr12:38710491 ALG10B -0.68 -10.55 -0.5 1.2e-22 Morning vs. evening chronotype; LUSC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg09034736 chr1:150693464 HORMAD1 0.41 5.85 0.3 1.19e-8 Melanoma; LUSC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.65 13.97 0.61 3.15e-35 Hemoglobin concentration; LUSC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg13647721 chr17:30228624 UTP6 0.63 6.83 0.35 3.96e-11 Hip circumference adjusted for BMI; LUSC cis rs4285028 0.948 rs35737776 chr3:121677856 G/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.57 -0.46 2.41e-19 Multiple sclerosis; LUSC trans rs2898290 0.617 rs13278965 chr8:11466745 A/T cg06636001 chr8:8085503 FLJ10661 0.52 7.96 0.4 2.77e-14 Systolic blood pressure; LUSC cis rs751728 0.865 rs751726 chr6:33764386 G/A cg25922239 chr6:33757077 LEMD2 0.55 8.26 0.41 3.56e-15 Crohn's disease; LUSC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg23583168 chr7:148888333 NA -0.84 -14.78 -0.63 2.16e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.03 -0.31 4.44e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg03388025 chr16:89894329 SPIRE2 0.33 6.93 0.35 2.24e-11 Vitiligo; LUSC cis rs921968 0.565 rs7562426 chr2:219605118 G/A cg02176678 chr2:219576539 TTLL4 -0.57 -10.1 -0.48 4.29e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs1577917 1.000 rs34852683 chr6:86702330 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.34 -0.33 7.59e-10 Response to antipsychotic treatment; LUSC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg07636037 chr3:49044803 WDR6 0.59 6.25 0.32 1.28e-9 Menarche (age at onset); LUSC trans rs7824557 0.527 rs2572376 chr8:11237756 C/A cg08975724 chr8:8085496 FLJ10661 -0.42 -6.14 -0.32 2.39e-9 Retinal vascular caliber; LUSC cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg08999081 chr20:33150536 PIGU 0.44 8.12 0.41 8.93e-15 Coronary artery disease; LUSC cis rs17270561 0.609 rs2000351 chr6:25759783 T/C cg17691542 chr6:26056736 HIST1H1C 0.53 7.36 0.37 1.4e-12 Iron status biomarkers; LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg12419862 chr22:24373484 LOC391322 1.03 21.96 0.77 8.84e-67 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11711311 1.000 rs891574 chr3:113537639 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.43 0.33 4.3e-10 IgG glycosylation; LUSC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg15704280 chr7:45808275 SEPT13 -0.55 -7.83 -0.39 6.43e-14 Coronary artery disease; LUSC cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg23711669 chr6:146136114 FBXO30 0.72 12.82 0.57 7.47e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs4555082 0.957 rs8022526 chr14:105756485 A/G cg13114125 chr14:105738426 BRF1 -0.88 -14.64 -0.63 7.72e-38 Mean platelet volume;Platelet distribution width; LUSC cis rs9928842 0.882 rs9319481 chr16:75259478 T/C cg09066997 chr16:75300724 BCAR1 0.52 6.46 0.33 3.75e-10 Alcoholic chronic pancreatitis; LUSC cis rs1950626 0.623 rs34603287 chr14:101433831 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.47 0.38 7.07e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs950169 0.610 rs34529571 chr15:84691807 A/G cg11189052 chr15:85197271 WDR73 0.54 6.13 0.32 2.42e-9 Schizophrenia; LUSC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.47 8.73 0.43 1.26e-16 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.44e-23 Bladder cancer; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg14004847 chr7:1930337 MAD1L1 -0.51 -7.84 -0.39 6.14e-14 Bipolar disorder and schizophrenia; LUSC cis rs11971779 0.553 rs10269108 chr7:139106332 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs394563 0.602 rs409111 chr6:149766860 A/G cg07828024 chr6:149772892 ZC3H12D -0.33 -7.37 -0.37 1.34e-12 Dupuytren's disease; LUSC cis rs2204008 0.571 rs8175738 chr12:38311234 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.67 -0.34 1.03e-10 Bladder cancer; LUSC cis rs372883 0.600 rs407712 chr21:30722531 G/A cg24692254 chr21:30365293 RNF160 -0.75 -11.68 -0.54 1.18e-26 Pancreatic cancer; LUSC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg03676636 chr4:99064102 C4orf37 0.37 7.68 0.39 1.8e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.03e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11229555 1.000 rs2298608 chr11:58404467 A/G cg15696309 chr11:58395628 NA 0.7 9.25 0.45 2.82e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9649213 0.614 rs2240348 chr7:97984077 C/T cg08684580 chr7:98029266 BAIAP2L1 0.37 5.64 0.3 3.56e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7917772 0.582 rs12779854 chr10:104358474 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.81 -0.51 1.47e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9420 0.961 rs7121169 chr11:57452543 G/A cg23127183 chr11:57508653 C11orf31 -0.58 -8.99 -0.44 1.86e-17 Schizophrenia; LUSC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg14668632 chr7:2872130 GNA12 -0.42 -6.38 -0.33 5.87e-10 Height; LUSC cis rs9359856 0.636 rs9344946 chr6:90298371 T/G cg13799429 chr6:90582589 CASP8AP2 0.71 7.5 0.38 5.9e-13 Bipolar disorder; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg20821713 chr7:1055600 C7orf50 -0.39 -6.1 -0.32 3.01e-9 Longevity;Endometriosis; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg17073432 chr10:104221224 TMEM180 0.37 6.0 0.31 5.06e-9 Metabolite levels (Pyroglutamine); LUSC cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.9 0.48 1.98e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6893807 1.000 rs16903275 chr5:87950543 A/C cg09002922 chr5:87956389 LOC645323 0.43 5.67 0.3 3.03e-8 Body mass index; LUSC trans rs7824557 0.628 rs7008205 chr8:11197323 T/G cg15556689 chr8:8085844 FLJ10661 0.48 7.21 0.37 3.87e-12 Retinal vascular caliber; LUSC cis rs56161922 1.000 rs56235509 chr1:207839769 C/G cg11752769 chr1:207818423 CR1L -0.67 -5.78 -0.3 1.73e-8 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg26304593 chr6:42947056 PEX6 -0.53 -8.4 -0.42 1.3e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg06873352 chr17:61820015 STRADA 0.56 8.57 0.42 3.99e-16 Height; LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.88 -12.17 -0.55 1.89e-28 Platelet count; LUSC cis rs7582180 0.629 rs11684516 chr2:100949883 C/A cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs4654899 0.571 rs6692677 chr1:21251717 C/T cg01072550 chr1:21505969 NA -0.51 -7.74 -0.39 1.22e-13 Superior frontal gyrus grey matter volume; LUSC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg16743903 chr16:89593216 SPG7 -0.43 -6.44 -0.33 4.05e-10 Multiple myeloma (IgH translocation); LUSC cis rs9929218 0.551 rs2296406 chr16:68721340 G/A cg01251360 chr16:68772225 CDH1 -0.27 -6.53 -0.34 2.43e-10 Colorectal cancer; LUSC cis rs13401104 0.796 rs11894118 chr2:237119192 C/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08704250 chr15:31115839 NA -0.47 -7.06 -0.36 9.84e-12 Huntington's disease progression; LUSC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.41 8.4 0.42 1.34e-15 Autism spectrum disorder or schizophrenia; LUSC cis rs7589342 0.929 rs1465640 chr2:106439103 C/T cg16077055 chr2:106428750 NCK2 0.37 7.1 0.36 7.78e-12 Addiction; LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg14440974 chr22:39074834 NA -0.38 -6.37 -0.33 6.21e-10 Menopause (age at onset); LUSC trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg11887960 chr12:57824829 NA 0.58 7.11 0.36 7.27e-12 Lung disease severity in cystic fibrosis; LUSC cis rs2486288 0.656 rs8040185 chr15:45552081 G/A cg09092052 chr15:45571596 NA 0.45 6.26 0.32 1.18e-9 Glomerular filtration rate; LUSC cis rs1832871 0.683 rs62437360 chr6:158720162 G/A cg07165851 chr6:158734300 TULP4 0.5 7.66 0.39 2.05e-13 Height; LUSC cis rs7937890 1.000 rs2970335 chr11:14325401 A/C cg19336497 chr11:14380999 RRAS2 -0.43 -7.77 -0.39 9.84e-14 Mitochondrial DNA levels; LUSC trans rs75804782 0.641 rs41264155 chr2:239342096 G/A cg01134436 chr17:81009848 B3GNTL1 0.66 6.08 0.32 3.31e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg11584989 chr19:19387371 SF4 0.67 7.76 0.39 1.05e-13 Bipolar disorder; LUSC cis rs3099143 0.901 rs1813479 chr15:77168646 T/C cg21673338 chr15:77095150 SCAPER 0.82 7.79 0.39 8.72e-14 Recalcitrant atopic dermatitis; LUSC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg12310025 chr6:25882481 NA 0.63 10.55 0.5 1.17e-22 Blood metabolite levels; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg02353165 chr6:42928485 GNMT 0.71 12.23 0.56 1.13e-28 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg22455342 chr2:225449267 CUL3 0.81 10.73 0.51 2.77e-23 IgE levels in asthmatics (D.p. specific); LUSC cis rs684232 0.666 rs366151 chr17:598311 A/C cg12384639 chr17:618140 VPS53 0.33 5.7 0.3 2.61e-8 Prostate cancer; LUSC cis rs73198271 0.562 rs17631052 chr8:8663787 G/A cg01851573 chr8:8652454 MFHAS1 0.63 8.04 0.4 1.53e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs208520 0.690 rs10455594 chr6:66737894 C/G cg07460842 chr6:66804631 NA 1.1 17.23 0.69 4.59e-48 Exhaled nitric oxide output; LUSC cis rs4363385 0.818 rs2711 chr1:153005156 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs9287719 0.649 rs11684537 chr2:10734832 C/T cg00105475 chr2:10696890 NA 0.35 5.85 0.3 1.18e-8 Prostate cancer; LUSC trans rs1864729 0.748 rs2583509 chr8:98294151 G/A cg08679828 chr8:102218111 ZNF706 -0.69 -6.06 -0.31 3.77e-9 Estradiol plasma levels (breast cancer); LUSC cis rs734999 0.572 rs2985857 chr1:2532624 C/T cg18854424 chr1:2615690 NA -0.49 -9.76 -0.47 5.92e-20 Ulcerative colitis; LUSC cis rs2625529 0.618 rs6494992 chr15:72420750 G/C cg16672083 chr15:72433130 SENP8 0.49 8.11 0.41 9.85e-15 Red blood cell count; LUSC trans rs7849782 0.967 rs4743480 chr9:104421888 G/T cg22914338 chr19:14376960 NA 0.26 6.36 0.33 6.77e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg22467129 chr15:76604101 ETFA -0.49 -8.0 -0.4 2.04e-14 Blood metabolite levels; LUSC cis rs35362007 0.530 rs10484053 chr14:96011645 C/T cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.58 5.67 0.3 3.09e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6939532 0.648 rs9379862 chr6:26370707 T/C cg09904177 chr6:26538194 HMGN4 -0.48 -6.69 -0.34 9.2e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs1728785 1.000 rs1645981 chr16:68571648 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.12 0.58 5.24e-32 Platelet count; LUSC cis rs11969893 0.850 rs9498414 chr6:101322976 C/T cg12253828 chr6:101329408 ASCC3 1.09 9.89 0.48 2.2e-20 Economic and political preferences (immigration/crime); LUSC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg18190219 chr22:46762943 CELSR1 -0.52 -6.0 -0.31 5.08e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg18099408 chr3:52552593 STAB1 -0.4 -6.85 -0.35 3.62e-11 Bipolar disorder; LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.28 0.45 2.15e-18 Prudent dietary pattern; LUSC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg03433033 chr1:76189801 ACADM -0.72 -9.65 -0.47 1.32e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2839186 0.749 rs62226489 chr21:47710519 T/C cg13126279 chr21:47581558 C21orf56 -0.42 -6.14 -0.32 2.3e-9 Testicular germ cell tumor; LUSC cis rs11603020 0.950 rs78364821 chr11:57370742 C/T cg23127183 chr11:57508653 C11orf31 -0.46 -6.4 -0.33 5.22e-10 Blood protein levels; LUSC cis rs10865541 0.902 rs7593978 chr2:3415544 C/T cg15807143 chr2:3452624 TTC15 0.33 5.75 0.3 2.02e-8 Obesity-related traits; LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.11 -0.32 2.85e-9 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.7 0.3 2.64e-8 Menopause (age at onset); LUSC cis rs2324229 0.828 rs1180231 chr6:83948817 G/A cg08257003 chr6:84140564 ME1 0.28 6.78 0.35 5.51e-11 Platelet-derived growth factor BB levels; LUSC cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs7582180 0.629 rs13025184 chr2:100944842 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7804356 0.953 rs73069539 chr7:26903661 C/T cg03456212 chr7:26904342 SKAP2 -0.55 -6.27 -0.32 1.14e-9 Type 1 diabetes; LUSC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg07636037 chr3:49044803 WDR6 -1.07 -19.03 -0.72 3.19e-55 Parkinson's disease; LUSC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 6.0 0.31 5.19e-9 Personality dimensions; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg11843238 chr5:131593191 PDLIM4 0.38 7.0 0.36 1.45e-11 Blood metabolite levels; LUSC cis rs447735 0.566 rs258337 chr16:89720710 T/A cg06640241 chr16:89574553 SPG7 0.39 5.77 0.3 1.81e-8 Hemoglobin concentration; LUSC trans rs941408 0.515 rs12610096 chr19:2778129 C/T cg19676328 chr12:49525230 TUBA1B -0.52 -7.37 -0.37 1.37e-12 Total cholesterol levels; LUSC cis rs694739 0.734 rs663743 chr11:64107735 G/A cg23796481 chr11:64053134 BAD;GPR137 0.59 9.1 0.45 8.43e-18 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs2840044 0.534 rs2124246 chr17:33885431 G/A cg19694781 chr19:47549865 TMEM160 -0.42 -6.73 -0.35 7.62e-11 Response to radiotherapy in cancer (late toxicity); LUSC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg08975724 chr8:8085496 FLJ10661 0.5 7.38 0.37 1.3e-12 Joint mobility (Beighton score); LUSC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg11764359 chr7:65958608 NA -0.7 -10.64 -0.5 5.9e-23 Aortic root size; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.98 0.77 7.28e-67 Prudent dietary pattern; LUSC cis rs7267979 0.932 rs6115215 chr20:25562500 C/T cg08601574 chr20:25228251 PYGB 0.39 5.9 0.31 9.14e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg17294928 chr15:75287854 SCAMP5 -0.76 -10.13 -0.48 3.23e-21 Blood trace element (Zn levels); LUSC trans rs35110281 0.667 rs4819285 chr21:45118970 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.6 -10.36 -0.49 5.53e-22 Mean corpuscular volume; LUSC cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg24692254 chr21:30365293 RNF160 -0.69 -10.64 -0.5 5.98e-23 Pancreatic cancer; LUSC cis rs9329289 0.510 rs12359941 chr10:2547015 G/A cg15501526 chr10:2543763 NA 0.57 10.12 0.48 3.63e-21 Age-related hearing impairment; LUSC trans rs3774749 0.565 rs2518796 chr3:50207075 A/G cg21659725 chr3:3221576 CRBN 0.51 7.9 0.4 4.12e-14 Intelligence (multi-trait analysis); LUSC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -8.01 -0.4 1.94e-14 Blood pressure (smoking interaction); LUSC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.87 0.31 1.07e-8 Menopause (age at onset); LUSC cis rs7589342 0.929 rs1465640 chr2:106439103 C/T cg14210321 chr2:106509881 NCK2 -0.54 -8.15 -0.41 7.26e-15 Addiction; LUSC trans rs1005277 0.557 rs1854563 chr10:38434961 G/A cg17830980 chr10:43048298 ZNF37B -0.58 -9.59 -0.46 2.1e-19 Extrinsic epigenetic age acceleration; LUSC cis rs9902453 0.704 rs1972305 chr17:28533880 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.5 7.22 0.37 3.56e-12 Coffee consumption (cups per day); LUSC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.72 -0.39 1.4e-13 Aortic root size; LUSC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg12310025 chr6:25882481 NA -0.47 -7.77 -0.39 9.61e-14 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC trans rs4942242 0.659 rs1105586 chr13:44232633 C/T cg19169023 chr15:41853346 TYRO3 0.63 10.45 0.5 2.59e-22 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.28 0.32 1.08e-9 Tonsillectomy; LUSC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC trans rs11098499 0.730 rs78971550 chr4:120281041 C/T cg25214090 chr10:38739885 LOC399744 0.5 7.47 0.38 6.93e-13 Corneal astigmatism; LUSC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg09655341 chr17:79618100 PDE6G -0.28 -6.53 -0.34 2.47e-10 Eye color traits; LUSC cis rs950881 0.932 rs13408661 chr2:102955082 G/A cg20060108 chr2:102954350 IL1RL1 0.45 5.9 0.31 8.86e-9 Allergy; LUSC cis rs231513 0.954 rs231497 chr17:41975947 A/G cg26893861 chr17:41843967 DUSP3 -0.51 -6.1 -0.32 2.93e-9 Cognitive function; LUSC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg21963583 chr11:68658836 MRPL21 0.56 8.35 0.42 1.89e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.54 -8.44 -0.42 9.58e-16 Lymphocyte counts; LUSC cis rs9902453 0.967 rs55744550 chr17:28475729 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 7.95 0.4 2.9e-14 Coffee consumption (cups per day); LUSC cis rs9527 0.590 rs2281877 chr10:104866062 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs80282103 0.867 rs11250242 chr10:1100064 A/C cg18964960 chr10:1102726 WDR37 -0.67 -6.1 -0.32 2.97e-9 Glomerular filtration rate (creatinine); LUSC cis rs870825 0.616 rs2310108 chr4:185639475 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs617219 0.889 rs10942887 chr5:78464012 G/T cg24856658 chr5:78533917 JMY -0.29 -5.67 -0.3 3.1e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg17264618 chr3:40429014 ENTPD3 0.32 6.81 0.35 4.57e-11 Renal cell carcinoma; LUSC cis rs3857536 0.642 rs7755840 chr6:66891913 A/G cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs12368653 0.840 rs3816896 chr12:58195773 C/T cg12615879 chr12:58013172 SLC26A10 0.28 6.62 0.34 1.4e-10 Multiple sclerosis; LUSC cis rs4665630 0.522 rs114880940 chr2:23930352 G/A cg08063864 chr2:24346004 PFN4;LOC375190 0.96 8.2 0.41 5.06e-15 Hypertension; LUSC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg02423579 chr7:2872169 GNA12 -0.44 -6.09 -0.32 3.19e-9 Height; LUSC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg19717773 chr7:2847554 GNA12 -0.38 -5.88 -0.31 1.01e-8 Height; LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg10729496 chr3:10149963 C3orf24 0.52 6.88 0.35 2.9100000000000002e-11 Alzheimer's disease; LUSC cis rs709400 0.659 rs3825566 chr14:103852725 C/T cg10523860 chr14:103875565 MARK3 0.38 6.02 0.31 4.67e-9 Body mass index; LUSC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg15556689 chr8:8085844 FLJ10661 0.69 11.15 0.52 9.5e-25 Joint mobility (Beighton score); LUSC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg11764359 chr7:65958608 NA -0.68 -10.89 -0.51 7.48e-24 Aortic root size; LUSC cis rs4622329 0.615 rs7975321 chr12:102288613 C/T cg23541617 chr12:102225335 GNPTAB 0.26 6.07 0.32 3.51e-9 Systemic lupus erythematosus; LUSC cis rs73129298 0.551 rs6012789 chr20:48601519 T/C cg25655593 chr20:48599521 SNAI1 0.59 6.36 0.33 6.69e-10 Inflammatory skin disease; LUSC cis rs7809950 1.000 rs2712191 chr7:107182724 C/G cg23024343 chr7:107201750 COG5 -0.56 -8.82 -0.43 6.64e-17 Coronary artery disease; LUSC cis rs17608059 0.518 rs4792436 chr17:13972307 T/A cg11395062 chr17:14139857 CDRT15 -0.51 -7.9 -0.4 4.15e-14 Temperament; LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg14004847 chr7:1930337 MAD1L1 -0.52 -8.08 -0.4 1.19e-14 Bipolar disorder and schizophrenia; LUSC cis rs8044995 0.563 rs57434514 chr16:68402649 G/A cg05110241 chr16:68378359 PRMT7 -0.85 -9.05 -0.44 1.19e-17 Schizophrenia; LUSC cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg06784218 chr1:46089804 CCDC17 -0.45 -8.95 -0.44 2.57e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8179 0.700 rs42039 chr7:92244422 A/G cg15732164 chr7:92237376 CDK6 0.49 6.79 0.35 5.18e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs9311676 0.632 rs56026131 chr3:58422483 C/G cg13750441 chr3:58318267 PXK 0.35 6.82 0.35 4.28e-11 Systemic lupus erythematosus; LUSC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs793571 0.523 rs12439457 chr15:58982390 T/C cg05156742 chr15:59063176 FAM63B 0.52 7.74 0.39 1.17e-13 Schizophrenia; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg16821394 chr5:141488611 NDFIP1 0.48 6.22 0.32 1.48e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7605827 0.930 rs10201564 chr2:15623608 C/G cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs8114671 0.562 rs6087644 chr20:33480917 G/C cg24642439 chr20:33292090 TP53INP2 0.46 6.4 0.33 5.17e-10 Height; LUSC cis rs8044995 0.563 rs57434514 chr16:68402649 G/A cg09835421 chr16:68378352 PRMT7 -0.82 -8.62 -0.43 2.76e-16 Schizophrenia; LUSC cis rs244293 0.965 rs244300 chr17:53239240 T/A cg19360675 chr17:53046073 COX11;STXBP4 -0.4 -5.79 -0.3 1.65e-8 Menarche (age at onset); LUSC cis rs8017423 0.967 rs12896540 chr14:90729392 T/C cg14092571 chr14:90743983 NA 0.36 5.76 0.3 1.91e-8 Mortality in heart failure; LUSC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg13393036 chr8:95962371 TP53INP1 -0.5 -10.46 -0.5 2.45e-22 Type 2 diabetes; LUSC cis rs7075426 0.669 rs4934211 chr10:88203735 C/T cg07322936 chr10:88137208 NA 0.46 6.57 0.34 1.88e-10 Migraine without aura; LUSC cis rs10791097 0.694 rs7106973 chr11:130758113 G/A cg12179176 chr11:130786555 SNX19 0.88 14.99 0.63 3.21e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg08742575 chr21:47604166 C21orf56 -0.48 -7.36 -0.37 1.42e-12 Testicular germ cell tumor; LUSC cis rs4474465 0.920 rs10793321 chr11:78237566 A/G cg27205649 chr11:78285834 NARS2 0.52 5.87 0.31 1.05e-8 Alzheimer's disease (survival time); LUSC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg27494647 chr7:150038898 RARRES2 0.58 8.54 0.42 4.69e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs9768139 0.903 rs10262701 chr7:158114591 G/A cg25566285 chr7:158114605 PTPRN2 -0.39 -7.37 -0.37 1.35e-12 Calcium levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04605084 chr1:91487590 ZNF644 -0.41 -6.21 -0.32 1.53e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2092850 1 rs2092850 chr6:88100419 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -5.9 -0.31 9.15e-9 Itch intensity from mosquito bite; LUSC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.4 -0.33 5.23e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1801251 1.000 rs13004406 chr2:233584557 A/T cg25237894 chr2:233734115 C2orf82 -0.35 -6.64 -0.34 1.29e-10 Coronary artery disease; LUSC cis rs7180079 1.000 rs6494477 chr15:64667334 T/C cg02848875 chr15:64387786 SNX1 0.42 5.84 0.3 1.25e-8 Monocyte count; LUSC cis rs782590 0.774 rs782632 chr2:55898290 C/G cg18811423 chr2:55921094 PNPT1 0.89 15.83 0.65 1.63e-42 Metabolic syndrome; LUSC cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.85 -0.39 5.73e-14 Chronic sinus infection; LUSC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg22963979 chr7:1858916 MAD1L1 -0.51 -7.49 -0.38 6.04e-13 Schizophrenia; LUSC cis rs2797160 1.000 rs1739362 chr6:126020703 A/T cg05901451 chr6:126070800 HEY2 0.57 8.58 0.43 3.59e-16 Endometrial cancer; LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.84 -0.44 5.51e-17 Bipolar disorder; LUSC cis rs4604732 0.631 rs34443739 chr1:247626913 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.43 6.41 0.33 4.93e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs834603 0.575 rs940861 chr7:47469429 A/T cg09696706 chr7:47479511 TNS3 0.32 5.75 0.3 2.01e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs10789491 1.000 rs1545206 chr1:47185082 C/G cg15501359 chr1:47185051 KIAA0494 0.82 11.28 0.53 3.23e-25 Response to hepatitis C treatment; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg07507251 chr3:52567010 NT5DC2 -0.35 -6.86 -0.35 3.27e-11 Bipolar disorder; LUSC cis rs6693567 0.565 rs698921 chr1:150379517 G/A cg15654264 chr1:150340011 RPRD2 0.44 7.16 0.36 5.07e-12 Migraine; LUSC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg21672276 chr3:44754072 ZNF502 -0.36 -5.71 -0.3 2.45e-8 Depressive symptoms; LUSC cis rs4388249 0.651 rs31608 chr5:108999512 A/G cg17395555 chr5:108820864 NA 0.43 5.74 0.3 2.12e-8 Schizophrenia; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.32 0.56 5.14e-29 Prudent dietary pattern; LUSC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg05347473 chr6:146136440 FBXO30 0.59 9.64 0.47 1.41e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs483180 0.512 rs606312 chr1:120222582 G/A cg19096424 chr1:120255104 PHGDH 0.48 6.46 0.33 3.61e-10 Macular telangiectasia type 2; LUSC cis rs9650315 0.929 rs36076243 chr8:57180599 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.8 0.35 4.85e-11 Height; LUSC cis rs4843747 0.641 rs11117353 chr16:88090895 A/G cg09044154 chr16:88155775 NA -0.61 -8.03 -0.4 1.69e-14 Menopause (age at onset); LUSC cis rs7107174 1.000 rs901103 chr11:77931346 C/T cg02023728 chr11:77925099 USP35 0.52 7.27 0.37 2.56e-12 Testicular germ cell tumor; LUSC cis rs11122272 0.670 rs2474632 chr1:231484361 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.09 -0.48 4.5e-21 Hemoglobin concentration; LUSC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06481639 chr22:41940642 POLR3H -0.47 -5.82 -0.3 1.41e-8 Vitiligo; LUSC cis rs2486288 0.656 rs1706770 chr15:45575062 T/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.82 -0.39 6.78e-14 Glomerular filtration rate; LUSC cis rs4478137 1.000 rs4478137 chr4:164238385 G/A cg06758707 chr4:164254230 NPY1R 0.65 10.03 0.48 7.17e-21 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg05025164 chr4:1340916 KIAA1530 0.63 10.18 0.49 2.21e-21 Longevity; LUSC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg11764359 chr7:65958608 NA -0.68 -10.32 -0.49 7.66e-22 Aortic root size; LUSC cis rs9303401 0.659 rs36093395 chr17:56957357 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.54 0.6 1.33e-33 Cognitive test performance; LUSC cis rs9905704 0.846 rs302878 chr17:56762964 G/A cg12560992 chr17:57184187 TRIM37 0.58 8.42 0.42 1.15e-15 Testicular germ cell tumor; LUSC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg19592336 chr6:28129416 ZNF389 0.47 6.38 0.33 5.77e-10 Parkinson's disease; LUSC cis rs11098499 0.866 rs6847778 chr4:120293582 A/G cg09307838 chr4:120376055 NA 0.7 10.12 0.48 3.71e-21 Corneal astigmatism; LUSC cis rs189798 0.807 rs330905 chr8:8993551 A/T cg15556689 chr8:8085844 FLJ10661 0.46 6.53 0.34 2.42e-10 Myopia (pathological); LUSC cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg27446573 chr6:127587934 RNF146 0.92 15.23 0.64 3.94e-40 Breast cancer; LUSC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg13319975 chr6:146136371 FBXO30 0.5 7.51 0.38 5.52e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs3845702 1.000 rs3768837 chr2:180835792 T/A cg01881094 chr2:180872142 CWC22 -0.81 -10.49 -0.5 1.85e-22 Schizophrenia; LUSC trans rs11098499 0.820 rs11737395 chr4:120520704 C/G cg25214090 chr10:38739885 LOC399744 0.52 7.78 0.39 8.9e-14 Corneal astigmatism; LUSC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.83 0.43 6.15e-17 Height; LUSC trans rs1814175 0.647 rs10839394 chr11:49844747 T/C cg03929089 chr4:120376271 NA -1.03 -19.41 -0.73 1.04e-56 Height; LUSC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg03806693 chr22:41940476 POLR3H 1.0 14.33 0.62 1.24e-36 Vitiligo; LUSC cis rs7177699 0.526 rs7166764 chr15:79123509 T/G cg00540400 chr15:79124168 NA 0.43 7.51 0.38 5.6e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs68170813 0.652 rs7784906 chr7:107148386 C/T cg02696742 chr7:106810147 HBP1 -0.64 -8.62 -0.43 2.79e-16 Coronary artery disease; LUSC cis rs7582720 1.000 rs72936872 chr2:203790889 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2625529 0.617 rs8557 chr15:72115733 T/C cg16672083 chr15:72433130 SENP8 -0.47 -7.62 -0.38 2.7e-13 Red blood cell count; LUSC cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg24812749 chr6:127587940 RNF146 -0.84 -12.06 -0.55 4.68e-28 Breast cancer; LUSC cis rs644148 0.730 rs2686766 chr19:44991595 T/G cg15540054 chr19:45004280 ZNF180 -0.52 -7.19 -0.37 4.4e-12 Personality dimensions; LUSC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg06544989 chr22:39130855 UNC84B 0.33 5.65 0.3 3.51e-8 Menopause (age at onset); LUSC cis rs35995292 0.926 rs10259755 chr7:38897012 A/C cg19327137 chr7:38886074 VPS41 0.34 5.67 0.3 3.17e-8 Subjective well-being (multi-trait analysis); LUSC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg18681998 chr4:17616180 MED28 0.88 16.94 0.68 7.03e-47 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2230307 0.536 rs2784173 chr1:100639752 A/G cg24955406 chr1:100503596 HIAT1 -0.58 -6.37 -0.33 6.09e-10 Carotid intima media thickness; LUSC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg13390004 chr1:15929781 NA 0.41 6.9 0.35 2.66e-11 Systolic blood pressure; LUSC trans rs2197308 0.667 rs11181073 chr12:37898543 A/G cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.26e-10 Morning vs. evening chronotype; LUSC trans rs7944735 0.517 rs7952205 chr11:48199227 A/G cg15704280 chr7:45808275 SEPT13 0.71 6.75 0.35 6.59e-11 Intraocular pressure; LUSC cis rs9303401 0.555 rs8071831 chr17:57292950 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 7.14 0.36 5.99e-12 Cognitive test performance; LUSC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.73 -0.35 7.19e-11 Alzheimer's disease (late onset); LUSC cis rs11190604 0.767 rs10736150 chr10:102195341 G/A cg07080220 chr10:102295463 HIF1AN -0.58 -7.95 -0.4 2.99e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg22907277 chr7:1156413 C7orf50 0.68 7.26 0.37 2.68e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs909002 0.811 rs11575883 chr1:32085485 G/A cg01639898 chr1:32083012 HCRTR1 0.27 6.35 0.33 7.1e-10 Intelligence (multi-trait analysis); LUSC cis rs2463822 1.000 rs951677 chr11:62107249 G/C cg06239285 chr11:62104954 ASRGL1 0.95 10.39 0.49 4.15e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg02782426 chr3:40428986 ENTPD3 0.39 7.31 0.37 2.04e-12 Renal cell carcinoma; LUSC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg03609598 chr5:56110824 MAP3K1 -0.4 -5.68 -0.3 2.94e-8 Initial pursuit acceleration; LUSC cis rs6977660 0.714 rs10950753 chr7:19817302 G/A cg05791153 chr7:19748676 TWISTNB 0.67 7.1 0.36 7.78e-12 Thyroid stimulating hormone; LUSC cis rs3796619 1.000 rs2290409 chr4:1067249 C/T cg27284194 chr4:1044797 NA -0.51 -8.12 -0.41 9.27e-15 Recombination rate (males); LUSC cis rs585510 1 rs585510 chr12:121000133 A/G cg27279351 chr12:120934652 DYNLL1 0.65 8.72 0.43 1.35e-16 Reticulocyte fraction of red cells; LUSC trans rs17815608 1.000 rs17815608 chr12:77398721 A/T cg18631743 chr22:20104954 RANBP1;TRMT2A -0.6 -7.29 -0.37 2.23e-12 Type 2 diabetes; LUSC cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg21770322 chr7:97807741 LMTK2 0.47 8.0 0.4 2.04e-14 Breast cancer; LUSC trans rs1814175 0.500 rs1825677 chr11:49233099 T/G cg15704280 chr7:45808275 SEPT13 -0.73 -10.72 -0.51 3.02e-23 Height; LUSC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg09555818 chr19:45449301 APOC2 0.47 8.56 0.42 4.22e-16 Blood protein levels; LUSC cis rs1443512 0.812 rs2044210 chr12:54335533 C/G cg25024717 chr12:54324583 NA -0.38 -6.39 -0.33 5.68e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7582180 0.627 rs4851312 chr2:101011241 G/A cg08017756 chr2:100939284 LONRF2 -0.43 -8.0 -0.4 2.04e-14 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.32 0.37 1.83e-12 Motion sickness; LUSC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg17376030 chr22:41985996 PMM1 -0.47 -5.76 -0.3 1.89e-8 Vitiligo; LUSC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06481639 chr22:41940642 POLR3H -0.54 -6.26 -0.32 1.17e-9 Vitiligo; LUSC cis rs2404602 0.692 rs67570291 chr15:77020502 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.14 -0.36 5.81e-12 Blood metabolite levels; LUSC cis rs11785400 0.701 rs9297968 chr8:143723009 A/G cg24634471 chr8:143751801 JRK 0.51 7.16 0.36 5.14e-12 Schizophrenia; LUSC cis rs11608355 0.810 rs2217971 chr12:109857666 G/C cg19025524 chr12:109796872 NA -0.38 -5.7 -0.3 2.6e-8 Neuroticism; LUSC cis rs7659604 0.521 rs4833235 chr4:122695136 C/A cg19748678 chr4:122722346 EXOSC9 -0.48 -6.92 -0.35 2.26e-11 Type 2 diabetes; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.54 -8.44 -0.42 9.58e-16 Lymphocyte counts; LUSC cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg14689365 chr7:158441557 NCAPG2 0.47 6.55 0.34 2.12e-10 Height; LUSC cis rs7095944 0.614 rs3824765 chr10:126433570 C/G cg08799069 chr10:126477246 METTL10 -0.41 -6.35 -0.33 6.97e-10 Asthma; LUSC cis rs9457247 0.602 rs2157388 chr6:167481912 G/A cg06454157 chr6:167490870 NA -0.3 -6.88 -0.35 3e-11 Crohn's disease; LUSC cis rs4268898 0.722 rs2288072 chr2:24390517 G/A cg06627628 chr2:24431161 ITSN2 0.54 7.47 0.38 7.13e-13 Asthma; LUSC cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.18 -0.41 5.94e-15 Axial length; LUSC cis rs11583043 1.000 rs7521424 chr1:101475901 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.81 0.3 1.49e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.08 0.52 1.59e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1908814 0.516 rs35391955 chr8:11796728 A/C cg08975724 chr8:8085496 FLJ10661 0.47 6.73 0.35 7.34e-11 Neuroticism; LUSC cis rs7267979 0.586 rs6050429 chr20:25183058 G/A cg08601574 chr20:25228251 PYGB 0.44 6.68 0.34 9.8e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7582180 0.652 rs12997725 chr2:100935136 A/G cg12002119 chr2:101014098 CHST10 0.34 5.71 0.3 2.48e-8 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.602 rs1727294 chr12:123616514 A/G cg00376283 chr12:123451042 ABCB9 0.67 8.52 0.42 5.51e-16 Neutrophil percentage of white cells; LUSC cis rs7949030 1.000 rs10897289 chr11:62400016 T/C cg13298116 chr11:62369859 EML3;MTA2 0.51 8.6 0.43 3.08e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg03433033 chr1:76189801 ACADM 0.81 14.37 0.62 8.78e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs752010 0.838 rs11210505 chr1:42104731 G/C cg06885757 chr1:42089581 HIVEP3 0.41 8.01 0.4 1.87e-14 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7829975 0.572 rs7005000 chr8:8796602 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.79 -0.43 8.22e-17 Mood instability; LUSC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg13206674 chr6:150067644 NUP43 0.54 8.42 0.42 1.15e-15 Lung cancer; LUSC cis rs6977660 0.714 rs2390156 chr7:19786138 A/T cg07541023 chr7:19748670 TWISTNB 0.67 6.71 0.34 8.19e-11 Thyroid stimulating hormone; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07589166 chr19:12902806 JUNB -0.45 -6.1 -0.32 2.98e-9 Bipolar disorder and schizophrenia; LUSC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -5.98 -0.31 5.75e-9 Personality dimensions; LUSC cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.37 0.49 4.91e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg12419862 chr22:24373484 LOC391322 0.88 14.47 0.62 3.55e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs7927771 0.800 rs11039200 chr11:47379646 A/C cg18512352 chr11:47633146 NA -0.45 -8.59 -0.43 3.47e-16 Subjective well-being; LUSC cis rs11098499 0.731 rs9995026 chr4:120490499 T/A cg24375607 chr4:120327624 NA 0.76 11.48 0.53 6.02e-26 Corneal astigmatism; LUSC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg00810483 chr4:3375144 RGS12 0.34 6.67 0.34 1.07e-10 Serum sulfate level; LUSC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg18225595 chr11:63971243 STIP1 0.49 6.1 0.32 2.88e-9 Attention deficit hyperactivity disorder; LUSC cis rs7084402 1.000 rs1427204 chr10:60267640 A/C cg07615347 chr10:60278583 BICC1 -0.36 -5.85 -0.3 1.18e-8 Refractive error; LUSC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg23262073 chr20:60523788 NA -0.42 -6.07 -0.32 3.45e-9 Body mass index; LUSC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.14e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg07636037 chr3:49044803 WDR6 1.02 17.78 0.7 3.23e-50 Parkinson's disease; LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.23 0.37 3.38e-12 Gut microbiome composition (summer); LUSC cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg14458575 chr2:238380390 NA 0.71 12.11 0.55 3.02e-28 Prostate cancer; LUSC cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg23158103 chr7:148848205 ZNF398 -0.49 -8.0 -0.4 2.01e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg13939156 chr17:80058883 NA -0.34 -6.82 -0.35 4.37e-11 Life satisfaction; LUSC cis rs9527 0.590 rs3861984 chr10:104916980 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.55 0.46 2.79e-19 Arsenic metabolism; LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18099408 chr3:52552593 STAB1 -0.41 -6.96 -0.36 1.84e-11 Bipolar disorder; LUSC cis rs6138458 1.000 rs7269416 chr20:24976196 T/G cg26195577 chr20:24973756 C20orf3 1.11 18.48 0.71 5e-53 Blood protein levels; LUSC cis rs3540 0.574 rs2657946 chr15:90967513 G/C cg22089800 chr15:90895588 ZNF774 0.59 9.22 0.45 3.56e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg20821713 chr7:1055600 C7orf50 -0.5 -6.62 -0.34 1.46e-10 Bronchopulmonary dysplasia; LUSC trans rs2840044 1.000 rs10068 chr17:33901965 C/G cg19694781 chr19:47549865 TMEM160 0.59 9.55 0.46 2.96e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs1801251 1.000 rs35212961 chr2:233582762 C/T cg08000102 chr2:233561755 GIGYF2 0.69 11.48 0.53 5.92e-26 Coronary artery disease; LUSC trans rs11098499 0.708 rs1546506 chr4:120241240 T/C cg25214090 chr10:38739885 LOC399744 0.46 6.95 0.36 1.94e-11 Corneal astigmatism; LUSC cis rs4380275 0.965 rs4375894 chr2:772567 G/C cg21665850 chr2:731073 NA 0.42 6.84 0.35 3.75e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs672059 1.000 rs672059 chr1:183162539 G/A ch.1.3577855R chr1:183094577 LAMC1 0.55 8.1 0.41 1.02e-14 Hypertriglyceridemia; LUSC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg13072238 chr3:49761600 GMPPB -0.36 -5.81 -0.3 1.43e-8 Body mass index; LUSC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.6 -5.66 -0.3 3.24e-8 Cerebrospinal P-tau181p levels; LUSC cis rs921968 0.541 rs514356 chr2:219375018 C/T cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC trans rs60843830 1.000 rs62114497 chr2:214837 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 10.28 0.49 1.01e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7568458 0.840 rs2886722 chr2:85742297 C/T cg02493740 chr2:85810744 VAMP5 0.35 6.4 0.33 5.41e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg23034840 chr1:205782522 SLC41A1 0.61 8.53 0.42 5e-16 Menarche (age at onset); LUSC cis rs7527798 1.000 rs12738067 chr1:207858527 G/C cg09232269 chr1:207846808 CR1L -0.32 -5.66 -0.3 3.33e-8 Erythrocyte sedimentation rate; LUSC cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg07636037 chr3:49044803 WDR6 0.57 6.12 0.32 2.62e-9 Menarche (age at onset); LUSC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs72960926 0.744 rs72967299 chr6:75034041 C/T cg03266952 chr6:74778945 NA -0.83 -7.04 -0.36 1.12e-11 Metabolite levels (MHPG); LUSC cis rs472402 0.560 rs10037161 chr5:6624294 C/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.41 -6.1 -0.32 2.9e-9 Response to amphetamines; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22448930 chr20:62205785 PRIC285 -0.45 -6.58 -0.34 1.84e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9467773 0.620 rs2504566 chr6:26660488 G/C cg05738196 chr6:26577821 NA 0.79 14.91 0.63 6.82e-39 Intelligence (multi-trait analysis); LUSC cis rs4908769 0.624 rs2708633 chr1:8439625 C/A cg00546117 chr1:8445545 RERE 0.29 5.7 0.3 2.65e-8 Allergy; LUSC cis rs6700896 0.500 rs4655555 chr1:66080269 T/A cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg02475777 chr4:1388615 CRIPAK 0.4 5.99 0.31 5.49e-9 Obesity-related traits; LUSC cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg04450456 chr4:17643702 FAM184B 0.38 6.41 0.33 5.02e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.68 10.6 0.5 8.17e-23 Lymphocyte counts; LUSC cis rs9467773 0.869 rs1796520 chr6:26410800 C/T cg11502198 chr6:26597334 ABT1 -0.48 -6.72 -0.35 7.63e-11 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg01579765 chr21:45077557 HSF2BP -0.51 -10.96 -0.51 4.46e-24 Mean corpuscular volume; LUSC cis rs10203711 0.933 rs11693286 chr2:239585278 A/T cg14580085 chr2:239553406 NA 0.39 6.47 0.33 3.56e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg19266014 chr7:2183958 MAD1L1 -0.35 -5.84 -0.3 1.23e-8 Bipolar disorder and schizophrenia; LUSC cis rs9393777 0.720 rs13217285 chr6:26999845 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.54 -6.11 -0.32 2.7e-9 Intelligence (multi-trait analysis); LUSC cis rs9942416 0.559 rs7734618 chr5:75033762 A/T cg19683494 chr5:74908142 NA -0.43 -5.85 -0.31 1.15e-8 Age-related disease endophenotypes; LUSC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg13395646 chr4:1353034 KIAA1530 -0.78 -13.22 -0.59 2.24e-32 Obesity-related traits; LUSC trans rs7980799 0.716 rs10161311 chr12:33623204 G/A cg26384229 chr12:38710491 ALG10B -0.59 -8.8 -0.43 7.7e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1858037 0.867 rs2118305 chr2:65605220 A/C cg08085232 chr2:65598271 SPRED2 -0.42 -6.21 -0.32 1.57e-9 Rheumatoid arthritis; LUSC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg12463550 chr7:65579703 CRCP -0.56 -8.33 -0.41 2.14e-15 Aortic root size; LUSC trans rs1478897 0.898 rs2248696 chr8:11393803 C/T cg15556689 chr8:8085844 FLJ10661 -0.43 -6.26 -0.32 1.19e-9 Systemic lupus erythematosus; LUSC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs17824933 0.778 rs17752099 chr11:60760794 G/C cg16817237 chr11:60793675 NA 0.41 6.42 0.33 4.78e-10 Multiple sclerosis; LUSC cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg08999081 chr20:33150536 PIGU -0.37 -6.77 -0.35 5.86e-11 Height; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.25 -5.65 -0.3 3.39e-8 Electroencephalogram traits; LUSC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg11645453 chr3:52864694 ITIH4 0.59 14.12 0.61 8.31e-36 Schizophrenia; LUSC cis rs12220238 1.000 rs10824128 chr10:76007903 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.18e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2439831 0.850 rs3862142 chr15:44064806 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs1784581 1.000 rs1618170 chr6:162400337 C/T cg17173639 chr6:162384350 PARK2 -0.81 -14.8 -0.63 1.77e-38 Itch intensity from mosquito bite; LUSC cis rs4478858 0.698 rs7543348 chr1:31804805 A/C cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC trans rs11098499 0.532 rs12512646 chr4:120585733 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.17 0.32 1.94e-9 Corneal astigmatism; LUSC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg26061582 chr7:22766209 IL6 0.51 7.42 0.38 9.69e-13 Lung cancer; LUSC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.77 7.4 0.38 1.13e-12 Cerebrospinal P-tau181p levels; LUSC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg21984481 chr17:79567631 NPLOC4 0.68 14.27 0.62 2.03e-36 Eye color traits; LUSC cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg15242686 chr22:24348715 GSTTP1 0.39 5.83 0.3 1.33e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7216064 1.000 rs12451721 chr17:65939075 G/A cg12091567 chr17:66097778 LOC651250 -0.76 -9.59 -0.46 2.18e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs9300255 0.602 rs10744147 chr12:123643729 A/G cg00376283 chr12:123451042 ABCB9 0.65 7.51 0.38 5.51e-13 Neutrophil percentage of white cells; LUSC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg11812906 chr14:75593930 NEK9 0.68 11.93 0.55 1.47e-27 Height; LUSC cis rs9527 0.590 rs1926029 chr10:104855670 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.51 -0.34 2.77e-10 Arsenic metabolism; LUSC cis rs8060686 0.641 rs73612222 chr16:68216072 A/G cg09835421 chr16:68378352 PRMT7 -0.52 -5.77 -0.3 1.8e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg02551604 chr5:131831745 NA -0.4 -6.25 -0.32 1.26e-9 Asthma (sex interaction); LUSC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.88 -0.81 4.68e-78 Height; LUSC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg22800045 chr5:56110881 MAP3K1 0.44 6.04 0.31 4.08e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs7746199 0.736 rs13209332 chr6:27520752 T/A cg09904177 chr6:26538194 HMGN4 -0.76 -6.23 -0.32 1.43e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs936229 0.813 rs2168519 chr15:75080872 T/C cg14664628 chr15:75095509 CSK -1.0 -16.98 -0.68 4.82e-47 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9398803 0.865 rs4418209 chr6:126819699 T/G cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.97e-9 Male-pattern baldness; LUSC cis rs28830936 0.966 rs2303518 chr15:42109975 T/G cg17847044 chr15:42102381 MAPKBP1 -0.27 -6.0 -0.31 5.05e-9 Diastolic blood pressure; LUSC cis rs80130819 0.515 rs1793912 chr12:48387052 A/C cg05342945 chr12:48394962 COL2A1 -0.44 -5.71 -0.3 2.54e-8 Prostate cancer; LUSC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.19e-30 Aortic root size; LUSC cis rs2732480 0.577 rs2634681 chr12:48733084 C/T cg04545296 chr12:48745243 ZNF641 -0.33 -6.23 -0.32 1.44e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg26061582 chr7:22766209 IL6 0.48 6.91 0.35 2.51e-11 Lung cancer; LUSC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.59 -8.54 -0.42 4.69e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs965604 1.000 rs11637656 chr15:78751961 C/T cg18825076 chr15:78729989 IREB2 -0.43 -6.9 -0.35 2.64e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs7824557 0.564 rs2572386 chr8:11236975 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.45 -0.38 8e-13 Retinal vascular caliber; LUSC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Vitiligo; LUSC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg05872129 chr22:39784769 NA -0.6 -11.15 -0.52 9.57e-25 Intelligence (multi-trait analysis); LUSC cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg08807101 chr21:30365312 RNF160 -0.69 -12.08 -0.55 3.97e-28 Dental caries; LUSC cis rs10170310 1.000 rs12691947 chr2:139264471 A/G cg03782584 chr2:139258740 SPOPL 0.33 5.86 0.31 1.12e-8 Response to antipsychotic treatment; LUSC cis rs9300255 0.602 rs1617434 chr12:123649486 A/G cg00376283 chr12:123451042 ABCB9 0.65 7.59 0.38 3.19e-13 Neutrophil percentage of white cells; LUSC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg07741184 chr6:167504864 NA 0.4 7.2 0.37 3.96e-12 Crohn's disease; LUSC cis rs9906944 0.707 rs729003 chr17:47117775 C/T cg14634687 chr17:47094252 IGF2BP1 0.31 6.63 0.34 1.36e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs10979 0.928 rs9496676 chr6:143895610 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.0 -0.55 7.59e-28 Hypospadias; LUSC trans rs57046232 0.552 rs6139968 chr20:6319606 A/C cg21095983 chr6:86352623 SYNCRIP 0.5 7.35 0.37 1.49e-12 Colorectal cancer; LUSC cis rs9318086 0.712 rs9318100 chr13:24442482 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.4 -6.05 -0.31 3.84e-9 Myopia (pathological); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11078358 chr6:71377548 SMAP1 0.69 5.96 0.31 6.29e-9 Cognitive performance; LUSC cis rs2279817 0.780 rs71644065 chr1:18001669 C/T cg21791023 chr1:18019539 ARHGEF10L -0.49 -5.99 -0.31 5.49e-9 Neuroticism; LUSC cis rs9309473 1.000 rs62151652 chr2:73700131 A/C cg20560298 chr2:73613845 ALMS1 -0.44 -6.35 -0.33 6.9e-10 Metabolite levels; LUSC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11890956 chr21:40555474 PSMG1 -0.74 -11.15 -0.52 9.24e-25 Menarche (age at onset); LUSC cis rs909341 0.909 rs914559 chr20:62369300 C/G cg09650180 chr20:62225654 GMEB2 0.46 5.85 0.3 1.18e-8 Atopic dermatitis; LUSC cis rs2486288 0.656 rs9921035 chr15:45546660 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.96 -0.4 2.72e-14 Glomerular filtration rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02243437 chr10:61469599 SLC16A9 0.4 5.97 0.31 6.06e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28647808 0.881 rs71483208 chr9:136258824 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC trans rs853679 0.517 rs9368552 chr6:28068426 A/G cg06606381 chr12:133084897 FBRSL1 -0.47 -6.11 -0.32 2.77e-9 Depression; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg24846343 chr22:24311635 DDTL 0.76 17.33 0.69 1.95e-48 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg16989086 chr20:62203971 PRIC285 0.47 6.64 0.34 1.28e-10 Glioblastoma; LUSC cis rs61931739 0.500 rs28624237 chr12:34457171 G/T cg06521331 chr12:34319734 NA -0.41 -6.33 -0.33 8.04e-10 Morning vs. evening chronotype; LUSC cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg07636037 chr3:49044803 WDR6 0.96 12.68 0.57 2.39e-30 Menarche (age at onset); LUSC cis rs733592 0.560 rs61918773 chr12:48421774 G/A cg24011408 chr12:48396354 COL2A1 -0.5 -8.01 -0.4 1.91e-14 Plateletcrit; LUSC cis rs9788682 0.747 rs2938671 chr15:78732754 A/G cg24631222 chr15:78858424 CHRNA5 -0.67 -8.94 -0.44 2.76e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs1864729 1.000 rs2635162 chr8:98283629 C/T cg08679828 chr8:102218111 ZNF706 -0.85 -8.0 -0.4 2.04e-14 Estradiol plasma levels (breast cancer); LUSC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg06634786 chr22:41940651 POLR3H 0.52 6.18 0.32 1.91e-9 Vitiligo; LUSC cis rs11642862 1.000 rs113454775 chr16:30809534 A/G cg02466173 chr16:30829666 NA -0.69 -7.33 -0.37 1.8e-12 Tonsillectomy; LUSC cis rs4631830 0.863 rs2843546 chr10:51518688 A/C cg16070123 chr10:51489643 NA -0.51 -8.16 -0.41 6.7e-15 Prostate-specific antigen levels; LUSC cis rs9611519 0.929 rs73174657 chr22:41434158 G/A cg13813247 chr22:41461852 NA -0.36 -6.52 -0.34 2.53e-10 Neuroticism; LUSC cis rs1028488 0.508 rs6456197 chr6:170620089 G/A cg20370364 chr6:170703943 FAM120B -0.51 -7.8 -0.39 7.94e-14 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs6460942 0.643 rs7780093 chr7:12233661 C/G cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs10992471 0.756 rs11792342 chr9:95143668 G/A cg14631576 chr9:95140430 CENPP -0.33 -5.93 -0.31 7.77e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg13685833 chr1:53393034 SCP2 0.4 6.1 0.32 2.93e-9 Monocyte count; LUSC cis rs9303542 0.694 rs9906950 chr17:46577167 A/G cg09704116 chr17:46666958 LOC404266 0.31 5.95 0.31 6.69e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg18758796 chr5:131593413 PDLIM4 0.39 6.6 0.34 1.57e-10 Breast cancer; LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.91 0.4 3.87e-14 Bipolar disorder; LUSC cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs6430585 0.941 rs7589832 chr2:136504101 A/C cg07169764 chr2:136633963 MCM6 0.84 11.37 0.53 1.59e-25 Corneal structure; LUSC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg13531842 chr10:38383804 ZNF37A -0.42 -6.49 -0.33 3.19e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg23791538 chr6:167370224 RNASET2 0.4 6.4 0.33 5.15e-10 Crohn's disease; LUSC cis rs295140 1.000 rs12614621 chr2:201171207 G/C cg04283868 chr2:201171347 SPATS2L 0.44 6.63 0.34 1.36e-10 QT interval; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg21782813 chr7:2030301 MAD1L1 0.34 5.69 0.3 2.85e-8 Bipolar disorder and schizophrenia; LUSC cis rs9815354 0.951 rs17063653 chr3:41863817 A/G cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.6e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg06640241 chr16:89574553 SPG7 0.9 15.94 0.66 5.93e-43 Multiple myeloma (IgH translocation); LUSC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg20607287 chr7:12443886 VWDE 0.58 7.01 0.36 1.32e-11 Coronary artery disease; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg10729496 chr3:10149963 C3orf24 0.54 7.21 0.37 3.76e-12 Alzheimer's disease; LUSC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -6.77 -0.35 5.81e-11 Developmental language disorder (linguistic errors); LUSC cis rs6964587 0.967 rs12535601 chr7:91718346 A/G cg01689657 chr7:91764605 CYP51A1 0.33 5.84 0.3 1.23e-8 Breast cancer; LUSC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg14440974 chr22:39074834 NA -0.38 -6.28 -0.33 1.04e-9 Menopause (age at onset); LUSC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg00555438 chr3:195578280 NA -0.35 -5.86 -0.31 1.14e-8 Bronchopulmonary dysplasia; LUSC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg00784671 chr22:46762841 CELSR1 -0.45 -6.18 -0.32 1.89e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg24675658 chr1:53192096 ZYG11B -0.61 -9.53 -0.46 3.37e-19 Monocyte count; LUSC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.39 0.56 3.01e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1568889 0.877 rs57202579 chr11:28221677 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 9.16 0.45 5.27e-18 Bipolar disorder; LUSC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg07507251 chr3:52567010 NT5DC2 0.34 6.54 0.34 2.35e-10 Bipolar disorder; LUSC cis rs4595586 0.545 rs12819186 chr12:39356912 C/T cg26384229 chr12:38710491 ALG10B 0.5 7.23 0.37 3.24e-12 Morning vs. evening chronotype; LUSC cis rs7674212 0.581 rs10516496 chr4:103942165 C/T cg16532752 chr4:104119610 CENPE -0.43 -5.83 -0.3 1.33e-8 Type 2 diabetes; LUSC cis rs9341808 0.558 rs2490234 chr6:80816966 G/C cg08355045 chr6:80787529 NA 0.48 8.21 0.41 5.05e-15 Sitting height ratio; LUSC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg05872129 chr22:39784769 NA -0.6 -11.15 -0.52 9.57e-25 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.870 rs3733338 chr4:1241472 G/A cg05025164 chr4:1340916 KIAA1530 0.42 6.38 0.33 6.07e-10 Obesity-related traits; LUSC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg21724239 chr8:58056113 NA 0.59 7.11 0.36 6.93e-12 Developmental language disorder (linguistic errors); LUSC cis rs2303282 0.716 rs8059717 chr16:56465425 C/T cg00500540 chr16:56394104 NA -0.43 -7.35 -0.37 1.52e-12 Breast cancer; LUSC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.82e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 0.882 rs10407933 chr19:19364319 A/G cg22782873 chr19:19639568 YJEFN3 -0.47 -5.7 -0.3 2.59e-8 Bipolar disorder; LUSC cis rs6692729 0.901 rs1295643 chr1:227071364 G/A cg10327440 chr1:227177885 CDC42BPA -0.51 -7.32 -0.37 1.91e-12 Electrodermal activity; LUSC cis rs9457247 0.967 rs1794696 chr6:167396174 T/C cg23791538 chr6:167370224 RNASET2 -0.41 -6.47 -0.33 3.42e-10 Crohn's disease; LUSC trans rs12406019 0.548 rs11162415 chr1:78612934 G/A cg20826526 chr3:156266748 SSR3 -0.45 -6.77 -0.35 5.96e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs61897795 0.628 rs174579 chr11:61605613 C/T cg21709803 chr11:61594965 FADS2 -0.4 -5.8 -0.3 1.57e-8 Neutrophil count;Sum basophil neutrophil counts; LUSC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg01017244 chr2:74357527 NA -0.65 -12.09 -0.55 3.56e-28 Gestational age at birth (maternal effect); LUSC trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.75 -0.39 1.13e-13 Neuroticism; LUSC cis rs10792830 1.000 rs7114331 chr11:85839719 G/A cg07180834 chr11:85838833 NA -0.3 -5.69 -0.3 2.82e-8 Psychosis and Alzheimer's disease; LUSC cis rs2651899 0.867 rs2742675 chr1:3079905 A/G cg22674798 chr1:3096360 PRDM16 0.31 7.15 0.36 5.64e-12 Migraine; LUSC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.08 0.48 5.06e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs9929218 0.581 rs12185157 chr16:68784587 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.01 22.39 0.77 1.93e-68 Colorectal cancer; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg07092213 chr7:1199455 ZFAND2A -0.62 -9.92 -0.48 1.72e-20 Longevity;Endometriosis; LUSC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg21963583 chr11:68658836 MRPL21 0.55 8.28 0.41 2.98e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12940923 1.000 rs34861306 chr17:56377187 G/A cg19466818 chr17:56409534 MIR142 -0.38 -6.51 -0.34 2.71e-10 Circulating myeloperoxidase levels (plasma); LUSC trans rs9291683 0.552 rs11736410 chr4:10017241 G/A cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Bone mineral density; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg00149659 chr3:10157352 C3orf10 -1.06 -14.92 -0.63 6.03e-39 Alzheimer's disease; LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg00945038 chr17:61921165 SMARCD2 -0.46 -8.15 -0.41 7.59e-15 Prudent dietary pattern; LUSC cis rs11190604 1.000 rs10883505 chr10:102280772 C/T cg23241863 chr10:102295624 HIF1AN 0.48 5.74 0.3 2.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7089973 0.604 rs11196952 chr10:116607592 G/A cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3126085 0.877 rs868304 chr1:152178568 G/A cg03465714 chr1:152285911 FLG -0.42 -5.85 -0.3 1.19e-8 Atopic dermatitis; LUSC cis rs1559088 0.600 rs7246566 chr19:33589618 A/T cg17764715 chr19:33622953 WDR88 0.59 8.88 0.44 4.04e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.8 -0.81 9.79e-78 Height; LUSC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.42 0.33 4.61e-10 Tonsillectomy; LUSC cis rs753778 1.000 rs4961257 chr8:142232704 A/G cg18755752 chr8:142205143 DENND3 0.53 7.31 0.37 2.05e-12 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg00339695 chr16:24857497 SLC5A11 -0.41 -7.17 -0.37 4.76e-12 Intelligence (multi-trait analysis); LUSC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg13877915 chr19:58951672 ZNF132 0.46 7.41 0.38 1.07e-12 Uric acid clearance; LUSC cis rs12997796 0.556 rs13004867 chr2:86982504 C/G cg25203885 chr2:87302643 LOC285074 -0.84 -8.58 -0.42 3.67e-16 Schizophrenia; LUSC cis rs2073300 1.000 rs6132622 chr20:23442240 A/T cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg03240473 chr21:43526662 UMODL1;C21orf128 -0.45 -7.17 -0.37 4.89e-12 IgG glycosylation; LUSC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg09975044 chr14:104007538 NA 0.36 5.67 0.3 3.06e-8 Intelligence (multi-trait analysis); LUSC cis rs77106637 1.000 rs11605166 chr11:72669777 T/C cg04827223 chr11:72435913 ARAP1 -0.7 -8.78 -0.43 8.88e-17 Type 2 diabetes; LUSC cis rs1799949 0.794 rs116409325 chr17:41445460 C/A cg05368731 chr17:41323189 NBR1 0.86 14.33 0.62 1.21e-36 Menopause (age at onset); LUSC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.92 -0.44 3.04e-17 Axial length; LUSC trans rs11098499 0.863 rs36040693 chr4:120477616 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs72717009 0.825 rs7552317 chr1:161479438 C/T cg23840854 chr1:161414152 NA -0.9 -11.13 -0.52 1.11e-24 Rheumatoid arthritis; LUSC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg04518342 chr5:131593106 PDLIM4 0.46 8.41 0.42 1.19e-15 Breast cancer; LUSC cis rs10927875 0.632 rs4481843 chr1:16128205 G/A cg21385522 chr1:16154831 NA -0.98 -18.46 -0.71 6.21e-53 Dilated cardiomyopathy; LUSC trans rs1005277 0.579 rs9299760 chr10:38377920 C/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.64 -0.47 1.44e-19 Extrinsic epigenetic age acceleration; LUSC cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg01475377 chr6:109611718 NA -0.43 -7.85 -0.39 5.56e-14 Reticulocyte fraction of red cells; LUSC trans rs7939886 0.920 rs61742348 chr11:55905078 C/T cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs231513 0.906 rs11657681 chr17:42005363 G/A cg26893861 chr17:41843967 DUSP3 0.56 5.76 0.3 1.91e-8 Cognitive function; LUSC cis rs2067615 0.579 rs4964489 chr12:107171808 A/G cg15890332 chr12:107067104 RFX4 0.34 6.2 0.32 1.66e-9 Heart rate; LUSC cis rs1358748 0.522 rs11208997 chr1:67560956 C/T cg02640540 chr1:67518911 SLC35D1 0.66 6.61 0.34 1.5e-10 Tuberculosis; LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg08219700 chr8:58056026 NA 0.68 7.92 0.4 3.63e-14 Developmental language disorder (linguistic errors); LUSC cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg25173405 chr17:45401733 C17orf57 0.39 6.19 0.32 1.74e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg03351412 chr1:154909251 PMVK 0.5 7.65 0.39 2.2e-13 Prostate cancer; LUSC cis rs4319547 0.585 rs7953007 chr12:122816977 A/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.32 -0.41 2.26e-15 Body mass index; LUSC trans rs8073060 0.660 rs58266733 chr17:34003812 A/T cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09409496 chr21:38738374 DYRK1A -0.55 -7.16 -0.36 5.21e-12 Bipolar disorder and schizophrenia; LUSC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg20203395 chr5:56204925 C5orf35 -0.72 -9.9 -0.48 1.96e-20 Initial pursuit acceleration; LUSC cis rs12422267 0.536 rs58521339 chr12:132609486 T/C cg09764611 chr12:132620959 NA -0.57 -8.28 -0.41 2.97e-15 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs500891 0.693 rs1170497 chr6:83987234 C/T cg08257003 chr6:84140564 ME1 0.33 7.29 0.37 2.25e-12 Platelet-derived growth factor BB levels; LUSC cis rs77741769 0.571 rs35905305 chr12:121328082 T/G cg02419362 chr12:121203948 SPPL3 0.46 8.57 0.42 4.01e-16 Mean corpuscular volume; LUSC cis rs7215564 0.818 rs901063 chr17:78595696 A/T cg23238734 chr17:78661607 RPTOR -0.47 -6.02 -0.31 4.69e-9 Myopia (pathological); LUSC cis rs4704187 0.595 rs6859176 chr5:74379425 T/C cg03227963 chr5:74354835 NA 0.31 6.73 0.35 7.4e-11 Response to amphetamines; LUSC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg07395648 chr5:131743802 NA 0.43 6.84 0.35 3.84e-11 Breast cancer;Mosquito bite size; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14071762 chr20:61904060 ARFGAP1 0.68 5.94 0.31 7.03e-9 Cognitive performance; LUSC cis rs1080500 1.000 rs1080500 chr3:53175017 C/T cg14092988 chr3:52407081 DNAH1 0.32 5.91 0.31 8.26e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs6500602 0.598 rs3859155 chr16:4593741 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.48 -6.36 -0.33 6.48e-10 Schizophrenia; LUSC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs8072100 0.782 rs28507314 chr17:45551402 C/T cg03886242 chr7:26192032 NFE2L3 -0.42 -6.66 -0.34 1.1e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7178572 0.568 rs12909924 chr15:77551445 T/G cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC trans rs6502050 0.799 rs4789667 chr17:80162143 C/T cg07393940 chr7:158741817 NA 0.35 6.36 0.33 6.65e-10 Life satisfaction; LUSC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg02423579 chr7:2872169 GNA12 -0.37 -5.73 -0.3 2.21e-8 Height; LUSC cis rs4853525 0.923 rs7578618 chr2:191733357 A/T cg11845111 chr2:191398756 TMEM194B -0.41 -6.05 -0.31 3.93e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs12579753 0.879 rs1987116 chr12:82156478 G/A cg21231944 chr12:82153410 PPFIA2 -0.39 -6.2 -0.32 1.7e-9 Resting heart rate; LUSC cis rs4561483 0.583 rs33636 chr16:11990323 C/G cg08843971 chr16:11963173 GSPT1 -0.41 -6.27 -0.32 1.12e-9 Testicular germ cell tumor; LUSC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg26597838 chr10:835615 NA 0.94 13.56 0.6 1.12e-33 Eosinophil percentage of granulocytes; LUSC cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg23711669 chr6:146136114 FBXO30 0.82 14.11 0.61 9.06e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs6076065 0.676 rs6083085 chr20:23336119 C/T cg11657817 chr20:23433608 CST11 -0.43 -8.11 -0.41 1e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs10992471 0.603 rs11794346 chr9:95247288 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.72 -0.39 1.36e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.13 15.93 0.66 6.52e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg08949621 chr15:42265044 EHD4 0.51 6.36 0.33 6.8e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg22903657 chr4:1355424 KIAA1530 -0.36 -6.04 -0.31 4.14e-9 Obesity-related traits; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg04025307 chr7:1156635 C7orf50 0.4 6.11 0.32 2.83e-9 Longevity;Endometriosis; LUSC cis rs7568458 0.684 rs7579147 chr2:85805654 G/A cg17127132 chr2:85788382 GGCX 0.43 6.13 0.32 2.42e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7264396 0.887 rs10359 chr20:34099789 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.54 -0.34 2.28e-10 Total cholesterol levels; LUSC cis rs6964587 1.000 rs6944591 chr7:91642714 T/C cg22117172 chr7:91764530 CYP51A1 0.31 5.7 0.3 2.7e-8 Breast cancer; LUSC cis rs11608355 0.545 rs11615336 chr12:109914802 C/A cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs7681440 0.630 rs356195 chr4:90683168 T/C cg06632027 chr4:90757378 SNCA 0.38 5.69 0.3 2.71e-8 Dementia with Lewy bodies; LUSC cis rs1372520 0.532 rs2583972 chr4:90747411 T/G cg15133208 chr4:90757351 SNCA -0.54 -8.4 -0.42 1.27e-15 Neuroticism; LUSC cis rs17001868 0.568 rs909669 chr22:40742417 C/T cg07138101 chr22:40742427 ADSL 0.61 7.31 0.37 2.03e-12 Mammographic density (dense area); LUSC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg01973587 chr1:228161476 NA 0.46 8.19 0.41 5.58e-15 Diastolic blood pressure; LUSC cis rs2777491 0.574 rs28700583 chr15:41714072 C/T cg18705301 chr15:41695430 NDUFAF1 -1.02 -21.31 -0.76 3.14e-64 Ulcerative colitis; LUSC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg15352829 chr14:105391018 PLD4 -0.42 -8.9 -0.44 3.73e-17 Rheumatoid arthritis; LUSC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg22535103 chr8:58192502 C8orf71 -0.84 -10.26 -0.49 1.19e-21 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg18681998 chr4:17616180 MED28 -0.85 -14.96 -0.63 4.39e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg17644776 chr2:200775616 C2orf69 0.55 9.59 0.46 2.09e-19 Osteoporosis; LUSC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg03526776 chr6:41159608 TREML2 0.33 6.12 0.32 2.67e-9 Alzheimer's disease (late onset); LUSC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -11.77 -0.54 5.29e-27 Systemic lupus erythematosus; LUSC cis rs12760731 0.565 rs12028024 chr1:178087423 G/T cg00404053 chr1:178313656 RASAL2 0.69 6.75 0.35 6.64e-11 Obesity-related traits; LUSC cis rs859767 0.679 rs1104801 chr2:135436601 G/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.45 -0.33 3.96e-10 Neuroticism; LUSC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg17971929 chr21:40555470 PSMG1 0.78 13.38 0.59 5.42e-33 Cognitive function; LUSC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg05340658 chr4:99064831 C4orf37 0.63 9.98 0.48 1.09e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.45 0.33 3.89e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11166629 1.000 rs6981735 chr8:135635730 T/C cg27224718 chr8:135614730 ZFAT 0.67 11.32 0.53 2.38e-25 Smoking quantity; LUSC cis rs2742417 1.000 rs1969624 chr3:45734818 C/T cg09608765 chr3:45636137 LIMD1 0.34 6.68 0.34 9.78e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs8060686 0.545 rs12596883 chr16:68172416 A/T cg05110241 chr16:68378359 PRMT7 -0.64 -6.94 -0.36 1.99e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg17971929 chr21:40555470 PSMG1 0.8 14.27 0.62 2.18e-36 Cognitive function; LUSC cis rs9513627 0.833 rs73556129 chr13:100113167 C/T cg25919922 chr13:100150906 NA -0.77 -6.69 -0.34 9.2e-11 Obesity-related traits; LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg14092988 chr3:52407081 DNAH1 0.31 6.17 0.32 2e-9 Bipolar disorder; LUSC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg23422044 chr7:1970798 MAD1L1 -0.65 -7.31 -0.37 2.04e-12 Bipolar disorder; LUSC trans rs4332037 0.950 rs62442895 chr7:1936938 G/A cg11693508 chr17:37793320 STARD3 0.65 7.91 0.4 3.9e-14 Bipolar disorder; LUSC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg05347473 chr6:146136440 FBXO30 -0.57 -9.83 -0.47 3.34e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg25427524 chr10:38739819 LOC399744 -0.67 -12.09 -0.55 3.73e-28 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg03233332 chr7:66118400 NA 0.45 6.39 0.33 5.58e-10 Aortic root size; LUSC cis rs7223966 1.000 rs11657120 chr17:61857218 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.96 0.36 1.86e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs11785693 0.862 rs11774126 chr8:4979583 A/C cg26367366 chr8:4980734 NA 0.79 9.47 0.46 5.27e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7572644 0.766 rs1911127 chr2:28279693 G/A cg27432699 chr2:27873401 GPN1 -0.54 -6.86 -0.35 3.44e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4243830 0.850 rs2412309 chr1:6603151 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -10.4 -0.49 3.84e-22 Body mass index; LUSC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg11742103 chr11:62369870 EML3;MTA2 -0.54 -9.01 -0.44 1.68e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg02951883 chr7:2050386 MAD1L1 -0.39 -6.68 -0.34 1.01e-10 Bipolar disorder and schizophrenia; LUSC cis rs12620999 0.941 rs62183343 chr2:237979163 T/C cg23555395 chr2:238036564 NA 0.45 7.87 0.4 5.05e-14 Systemic lupus erythematosus; LUSC cis rs79349575 0.783 rs62078372 chr17:47028989 T/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg16325326 chr1:53192061 ZYG11B -0.89 -16.43 -0.67 7.04e-45 Monocyte count; LUSC cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.44e-12 Motion sickness; LUSC cis rs644799 0.622 rs1255167 chr11:95500213 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.05 0.48 6.3e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs12310956 0.510 rs10844693 chr12:33865197 A/G cg26384229 chr12:38710491 ALG10B -0.55 -8.59 -0.43 3.46e-16 Morning vs. evening chronotype; LUSC trans rs72674100 1.000 rs72882343 chr4:97993924 G/A cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9341835 0.593 rs9449297 chr6:64164249 T/C cg03326410 chr6:64151739 NA -0.36 -5.8 -0.3 1.53e-8 Schizophrenia; LUSC cis rs7786877 0.626 rs11770389 chr7:100221218 T/G cg16850897 chr7:100343110 ZAN -0.47 -5.77 -0.3 1.79e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg19717773 chr7:2847554 GNA12 0.37 5.91 0.31 8.47e-9 Height; LUSC cis rs9916302 0.660 rs665413 chr17:37455678 T/A cg07936489 chr17:37558343 FBXL20 0.81 9.89 0.48 2.19e-20 Glomerular filtration rate (creatinine); LUSC cis rs3824867 0.920 rs4752836 chr11:47465095 T/C cg20307385 chr11:47447363 PSMC3 0.64 9.48 0.46 4.83e-19 Mean corpuscular hemoglobin; LUSC cis rs4285028 0.948 rs1920291 chr3:121672440 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.67 -0.47 1.19e-19 Multiple sclerosis; LUSC cis rs7712401 0.601 rs30072 chr5:122292220 C/A cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg09796270 chr17:17721594 SREBF1 0.33 5.66 0.3 3.25e-8 Total body bone mineral density; LUSC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg27494647 chr7:150038898 RARRES2 0.59 8.75 0.43 1.03e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg12698349 chr2:225449008 CUL3 0.72 9.15 0.45 5.67e-18 IgE levels in asthmatics (D.p. specific); LUSC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg18681998 chr4:17616180 MED28 0.85 15.84 0.65 1.54e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.99 0.4 2.15e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg04944784 chr2:26401820 FAM59B 0.62 8.19 0.41 5.57e-15 Gut microbiome composition (summer); LUSC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg15073853 chr19:18549131 ISYNA1 -0.32 -5.73 -0.3 2.2e-8 Breast cancer; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.28 -0.33 1.03e-9 Developmental language disorder (linguistic errors); LUSC cis rs3755132 0.866 rs6755261 chr2:15761783 T/G cg12888861 chr2:15731646 DDX1 0.51 7.15 0.36 5.42e-12 Wilms tumor; LUSC cis rs7772486 0.748 rs2748484 chr6:146333653 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -7.05 -0.36 1.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg24503407 chr1:205819492 PM20D1 1.0 20.94 0.75 8.61e-63 Menarche (age at onset); LUSC trans rs11098499 0.863 rs34308924 chr4:120481431 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs6138458 1.000 rs227632 chr20:24913729 G/A cg26195577 chr20:24973756 C20orf3 1.14 18.86 0.72 1.6e-54 Blood protein levels; LUSC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg11301795 chr4:187892539 NA -0.84 -16.67 -0.67 7.72e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs4925325 0.915 rs2427246 chr20:60517047 T/C cg13770153 chr20:60521292 NA -1.03 -15.91 -0.66 7.98e-43 Obesity-related traits; LUSC cis rs138341189 1 rs138341189 chr11:68224411 GATTGTGCCAAT/G cg20283391 chr11:68216788 NA -0.62 -5.9 -0.31 8.9e-9 Monobrow; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23563507 chr2:44001149 DYNC2LI1 -0.43 -6.57 -0.34 1.92e-10 Electrocardiographic conduction measures; LUSC cis rs16910800 1.000 rs2449439 chr11:23200798 C/T cg20040320 chr11:23191996 NA 0.44 6.52 0.34 2.58e-10 Cancer; LUSC cis rs2933343 0.700 rs1683787 chr3:128627021 C/T cg11901034 chr3:128598214 ACAD9 0.43 6.83 0.35 3.97e-11 IgG glycosylation; LUSC trans rs7824557 0.564 rs2736290 chr8:11234298 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.51 -0.38 5.52e-13 Retinal vascular caliber; LUSC cis rs9888739 1.000 rs36001237 chr16:31318257 A/T cg15817542 chr16:31343056 ITGAM -0.51 -6.13 -0.32 2.49e-9 Systemic lupus erythematosus; LUSC cis rs4704187 0.687 rs10050948 chr5:74484275 C/T cg03227963 chr5:74354835 NA 0.31 6.65 0.34 1.2e-10 Response to amphetamines; LUSC cis rs11997175 0.624 rs10435522 chr8:33698608 G/A ch.8.33884649F chr8:33765107 NA 0.42 5.91 0.31 8.61e-9 Body mass index; LUSC cis rs12908161 1.000 rs34570071 chr15:85280212 T/A cg12863693 chr15:85201151 NMB 0.41 8.58 0.42 3.65e-16 Schizophrenia; LUSC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg08499158 chr17:42289980 UBTF -0.5 -8.46 -0.42 8.61e-16 Total body bone mineral density; LUSC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.47e-9 Bipolar disorder; LUSC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.69 0.34 9.58e-11 Lung cancer; LUSC cis rs2290416 0.792 rs62522167 chr8:144678034 G/A cg14809332 chr8:144654887 C8orf73 0.54 6.51 0.34 2.83e-10 Attention deficit hyperactivity disorder; LUSC cis rs10992471 0.603 rs10992342 chr9:95212068 C/T cg14631576 chr9:95140430 CENPP -0.33 -6.0 -0.31 5.14e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs3087591 0.959 rs9893872 chr17:29571195 G/A cg24425628 chr17:29625626 OMG;NF1 -0.57 -8.26 -0.41 3.47e-15 Hip circumference; LUSC cis rs909685 0.590 rs3747177 chr22:39746168 C/A cg17798944 chr22:39715225 SNORD43;RPL3 0.55 6.97 0.36 1.74e-11 Rheumatoid arthritis; LUSC cis rs61935443 0.832 rs11107773 chr12:95282000 C/T cg21533806 chr12:95267307 NA 0.52 6.5 0.34 2.95e-10 Schizophrenia; LUSC cis rs6961069 0.671 rs28369066 chr7:80223327 A/G cg04458919 chr7:80252533 CD36 -0.41 -7.26 -0.37 2.77e-12 Platelet count; LUSC cis rs3744061 0.530 rs12450896 chr17:74629867 C/T cg27546012 chr17:74684504 MXRA7 0.35 5.79 0.3 1.58e-8 Retinal arteriolar caliber; LUSC cis rs12618769 0.597 rs17502889 chr2:99031745 A/G cg10123293 chr2:99228465 UNC50 0.47 7.9 0.4 3.99e-14 Bipolar disorder; LUSC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.08 -0.36 8.35e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg18099408 chr3:52552593 STAB1 -0.4 -6.92 -0.35 2.26e-11 Bipolar disorder; LUSC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg09365446 chr1:150670422 GOLPH3L 0.53 8.02 0.4 1.75e-14 Tonsillectomy; LUSC cis rs7584330 0.737 rs7584314 chr2:238361089 C/T cg14458575 chr2:238380390 NA 0.68 12.14 0.55 2.41e-28 Prostate cancer; LUSC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC cis rs61935443 0.720 rs11107776 chr12:95294283 T/G cg21533806 chr12:95267307 NA 0.5 6.16 0.32 2.06e-9 Schizophrenia; LUSC cis rs12530845 0.943 rs11984203 chr7:135325947 C/T cg23117316 chr7:135346802 PL-5283 0.56 9.47 0.46 5.18e-19 Red blood cell traits; LUSC trans rs72674100 1.000 rs13353562 chr4:97977235 T/C cg16405019 chr1:18959625 PAX7 -0.59 -6.39 -0.33 5.5e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg20607798 chr8:58055168 NA 0.53 5.99 0.31 5.44e-9 Developmental language disorder (linguistic errors); LUSC cis rs9311676 0.618 rs62258135 chr3:58403330 C/T cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs28493229 0.881 rs59459325 chr19:41175390 C/T cg21869046 chr19:41225005 ITPKC 0.54 7.0 0.36 1.45e-11 Kawasaki disease; LUSC cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg09184832 chr6:79620586 NA -0.44 -7.01 -0.36 1.33e-11 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4466137 0.951 rs336958 chr5:82973396 A/G cg15083037 chr5:83017644 HAPLN1 -0.52 -6.79 -0.35 5.27e-11 Prostate cancer; LUSC cis rs240764 0.717 rs239236 chr6:101099217 A/G cg09795085 chr6:101329169 ASCC3 0.41 5.92 0.31 7.91e-9 Neuroticism; LUSC cis rs2882667 0.858 rs10900856 chr5:138417746 C/T cg04439458 chr5:138467593 SIL1 0.47 9.2 0.45 3.88e-18 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg00409905 chr10:38381863 ZNF37A 0.39 6.7 0.34 8.99e-11 Extrinsic epigenetic age acceleration; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg07092213 chr7:1199455 ZFAND2A -0.63 -10.12 -0.48 3.46e-21 Longevity;Endometriosis; LUSC cis rs6754311 0.608 rs3739020 chr2:136602491 T/G cg07169764 chr2:136633963 MCM6 0.78 10.81 0.51 1.44e-23 Mosquito bite size; LUSC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg13798780 chr7:105162888 PUS7 0.58 6.1 0.32 2.86e-9 Bipolar disorder (body mass index interaction); LUSC trans rs61931739 0.534 rs11052986 chr12:34052578 T/C cg26384229 chr12:38710491 ALG10B 0.68 10.68 0.5 4.36e-23 Morning vs. evening chronotype; LUSC cis rs7523273 0.606 rs2488254 chr1:207941539 A/G cg22525895 chr1:207977042 MIR29B2 0.41 6.67 0.34 1.07e-10 Schizophrenia; LUSC cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg20019365 chr2:219134978 PNKD;AAMP 0.54 8.34 0.42 1.98e-15 Colorectal cancer; LUSC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.23e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg11244672 chr19:19639970 YJEFN3 -0.62 -7.63 -0.39 2.47e-13 Bipolar disorder; LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.86 0.4 5.31e-14 Prudent dietary pattern; LUSC trans rs11039798 0.925 rs7482967 chr11:48613527 T/A cg15704280 chr7:45808275 SEPT13 0.68 6.41 0.33 4.99e-10 Axial length; LUSC cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg22467129 chr15:76604101 ETFA -0.42 -6.74 -0.35 7.16e-11 Blood metabolite levels; LUSC cis rs713587 0.776 rs3731623 chr2:25163783 T/C cg15423357 chr2:25149977 NA 0.37 7.32 0.37 1.84e-12 Body mass index in non-asthmatics; LUSC cis rs6456156 0.586 rs6456154 chr6:167472256 C/T cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs11105298 0.891 rs10858903 chr12:89927972 G/A cg00757033 chr12:89920650 WDR51B 0.6 10.53 0.5 1.42e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs36093844 0.800 rs2044390 chr11:85569834 C/T cg25872744 chr11:85566296 CCDC83 -0.45 -5.85 -0.3 1.19e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg22467129 chr15:76604101 ETFA -0.41 -6.54 -0.34 2.29e-10 Blood metabolite levels; LUSC cis rs1348850 0.632 rs12467363 chr2:178502512 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.07 0.32 3.49e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1595825 0.891 rs7592344 chr2:198572461 C/T cg00982548 chr2:198649783 BOLL -0.53 -6.77 -0.35 5.8200000000000003e-11 Ulcerative colitis; LUSC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg00166722 chr3:10149974 C3orf24 -0.58 -8.16 -0.41 6.77e-15 Alzheimer's disease; LUSC cis rs7113850 0.541 rs78048500 chr11:24217764 T/G ch.11.24196551F chr11:24239977 NA 1.0 8.78 0.43 8.73e-17 Bone fracture in osteoporosis; LUSC cis rs2439831 0.571 rs689883 chr15:43812596 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.8 8.19 0.41 5.7e-15 Lung cancer in ever smokers; LUSC trans rs17607347 0.542 rs62052909 chr16:72564986 G/A cg12945194 chr11:64703312 GPHA2 0.38 6.06 0.31 3.74e-9 Intelligence (multi-trait analysis); LUSC cis rs593982 0.777 rs72941015 chr11:65457514 A/C cg08755490 chr11:65554678 OVOL1 -1.59 -12.17 -0.55 1.8e-28 Atopic dermatitis; LUSC cis rs10792830 0.640 rs572979 chr11:85803276 C/T cg07180834 chr11:85838833 NA -0.3 -5.95 -0.31 6.62e-9 Psychosis and Alzheimer's disease; LUSC cis rs11190604 1.000 rs11190555 chr10:102209160 A/G cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg08847533 chr14:75593920 NEK9 0.68 11.2 0.52 6.27e-25 Coronary artery disease; LUSC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.69 -0.47 1e-19 Bipolar disorder; LUSC cis rs2281845 0.507 rs12025414 chr1:201100496 A/G cg06714761 chr1:201096289 NA 0.43 7.73 0.39 1.25e-13 Permanent tooth development; LUSC cis rs9300255 0.507 rs1615350 chr12:123650335 C/T cg00376283 chr12:123451042 ABCB9 0.71 10.02 0.48 7.85e-21 Neutrophil percentage of white cells; LUSC cis rs12579753 0.917 rs2401003 chr12:82215192 G/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.1 -0.32 2.89e-9 Resting heart rate; LUSC cis rs2625529 0.730 rs12908882 chr15:72437572 G/A cg16672083 chr15:72433130 SENP8 -0.51 -7.53 -0.38 4.86e-13 Red blood cell count; LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg13560548 chr3:10150139 C3orf24 0.51 6.98 0.36 1.56e-11 Alzheimer's disease; LUSC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg05043794 chr9:111880884 C9orf5 -0.35 -7.62 -0.38 2.65e-13 Menarche (age at onset); LUSC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg02187348 chr16:89574699 SPG7 0.47 7.36 0.37 1.43e-12 Multiple myeloma (IgH translocation); LUSC trans rs8072100 0.840 rs9900360 chr17:45491979 C/T cg04995722 chr7:26192034 NFE2L3 -0.39 -6.31 -0.33 8.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs977987 0.806 rs11862095 chr16:75385418 T/A cg04384234 chr16:75411784 CFDP1 -0.4 -6.44 -0.33 4.23e-10 Dupuytren's disease; LUSC cis rs886126 0.761 rs4766556 chr12:111659074 A/G cg10833066 chr12:111807467 FAM109A 0.43 6.74 0.35 6.95e-11 Coronary heart disease; LUSC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg04553112 chr3:125709451 NA -0.5 -5.7 -0.3 2.7e-8 Blood pressure (smoking interaction); LUSC cis rs5758511 0.773 rs10154700 chr22:42365073 G/T cg00645731 chr22:42541494 CYP2D7P1 0.45 7.37 0.37 1.4e-12 Birth weight; LUSC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg16584290 chr5:462447 EXOC3 -0.34 -5.81 -0.3 1.46e-8 Cystic fibrosis severity; LUSC cis rs11758351 0.925 rs78932312 chr6:26194869 A/G cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC cis rs6076065 0.775 rs761723 chr20:23330720 A/G cg11657817 chr20:23433608 CST11 0.54 10.85 0.51 1.06e-23 Facial morphology (factor 15, philtrum width); LUSC cis rs7923609 1.000 rs10761723 chr10:64955581 C/T cg01631684 chr10:65280961 REEP3 -0.41 -6.46 -0.33 3.62e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg24596788 chr1:163392923 NA 0.41 6.89 0.35 2.75e-11 Motion sickness; LUSC cis rs7829975 0.591 rs12677543 chr8:8644274 G/C cg17143192 chr8:8559678 CLDN23 0.4 6.24 0.32 1.34e-9 Mood instability; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14029663 chr14:50582909 C14orf138 -0.42 -6.1 -0.32 3e-9 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg06022373 chr22:39101656 GTPBP1 0.8 12.42 0.56 2.15e-29 Menopause (age at onset); LUSC cis rs1577917 1.000 rs35419329 chr6:86702291 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.68 -0.43 1.8e-16 Response to antipsychotic treatment; LUSC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg04369109 chr6:150039330 LATS1 -0.59 -8.57 -0.42 3.98e-16 Lung cancer; LUSC cis rs4343996 0.727 rs4506106 chr7:3370201 C/T cg21248987 chr7:3385318 SDK1 -0.36 -6.28 -0.32 1.07e-9 Motion sickness; LUSC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg27398817 chr8:82754497 SNX16 -0.46 -6.12 -0.32 2.56e-9 Diastolic blood pressure; LUSC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -6.11 -0.32 2.81e-9 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.717 rs10518820 chr15:43888976 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.37 0.33 6.12e-10 Lung cancer in ever smokers; LUSC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg17385448 chr1:15911702 AGMAT 0.37 6.29 0.33 1e-9 Systolic blood pressure; LUSC cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.33 -0.41 2.18e-15 Schizophrenia; LUSC cis rs13256369 0.865 rs13277708 chr8:8573936 T/C cg17143192 chr8:8559678 CLDN23 0.57 8.34 0.42 2.01e-15 Obesity-related traits; LUSC cis rs2859741 0.528 rs59729868 chr1:37493710 G/A cg09363841 chr1:37513479 NA -0.39 -7.3 -0.37 2.15e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC trans rs7726839 0.540 rs72705097 chr5:655067 G/A cg11887960 chr12:57824829 NA 0.52 6.49 0.33 3.12e-10 Obesity-related traits; LUSC trans rs7937682 0.883 rs631490 chr11:111452040 G/C cg18187862 chr3:45730750 SACM1L 0.55 7.15 0.36 5.64e-12 Primary sclerosing cholangitis; LUSC cis rs9430161 0.645 rs6675082 chr1:11033797 T/C cg27631724 chr1:11040367 C1orf127 0.52 9.04 0.44 1.31e-17 Ewing sarcoma; LUSC cis rs782590 0.694 rs2627775 chr2:55877113 C/T cg03859395 chr2:55845619 SMEK2 0.81 14.43 0.62 5.07e-37 Metabolic syndrome; LUSC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.48 -0.38 6.64e-13 Developmental language disorder (linguistic errors); LUSC cis rs9650315 0.733 rs11991218 chr8:57206016 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs7216064 1.000 rs6504542 chr17:65836642 T/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.44 -0.46 6.6e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs1007190 0.570 rs8064954 chr17:42867443 A/C cg15406952 chr17:42872593 NA -0.53 -5.65 -0.3 3.46e-8 DNA methylation (variation); LUSC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg06634786 chr22:41940651 POLR3H 0.51 5.65 0.3 3.44e-8 Vitiligo; LUSC cis rs28655083 0.529 rs589002 chr16:77104044 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 7.04 0.36 1.12e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9807989 0.507 rs4851004 chr2:103009537 A/G cg03938978 chr2:103052716 IL18RAP -0.37 -7.06 -0.36 9.66e-12 Asthma; LUSC cis rs3768617 0.727 rs12066735 chr1:183101451 T/G ch.1.3577855R chr1:183094577 LAMC1 0.6 8.79 0.43 8.22e-17 Fuchs's corneal dystrophy; LUSC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14240646 chr10:27532245 ACBD5 0.71 8.19 0.41 5.42e-15 Breast cancer; LUSC trans rs7618501 0.633 rs6446189 chr3:50008566 A/G cg21659725 chr3:3221576 CRBN 0.63 10.36 0.49 5.25e-22 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21949518 chr2:264910 ACP1;SH3YL1 -0.45 -6.46 -0.33 3.7e-10 Electrocardiographic conduction measures; LUSC cis rs11190604 1.000 rs2489053 chr10:102353341 A/G cg16342193 chr10:102329863 NA -0.34 -5.99 -0.31 5.39e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg18512352 chr11:47633146 NA -0.46 -8.99 -0.44 1.87e-17 Subjective well-being; LUSC cis rs10089 0.904 rs2228112 chr5:127469859 A/G cg19767477 chr5:127420684 SLC12A2 -0.42 -5.65 -0.3 3.37e-8 Ileal carcinoids; LUSC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg08270630 chr22:50330655 NA 0.4 5.93 0.31 7.52e-9 Schizophrenia; LUSC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg21951975 chr1:209979733 IRF6 0.56 6.86 0.35 3.26e-11 Coronary artery disease; LUSC cis rs9457247 0.624 rs9457260 chr6:167466665 C/T cg06454157 chr6:167490870 NA -0.3 -6.93 -0.35 2.21e-11 Crohn's disease; LUSC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg08847533 chr14:75593920 NEK9 0.86 16.04 0.66 2.53e-43 Height; LUSC cis rs804280 0.565 rs1466785 chr8:11623456 C/T cg26752888 chr8:11627280 NEIL2 -0.46 -6.79 -0.35 5.14e-11 Myopia (pathological); LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg06387496 chr7:2775674 GNA12 0.38 6.04 0.31 4.02e-9 Height; LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg04944784 chr2:26401820 FAM59B -0.74 -10.91 -0.51 6.48e-24 Gut microbiome composition (summer); LUSC cis rs3008870 1.000 rs2985797 chr1:67431499 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -14.94 -0.63 5.4300000000000003e-39 Lymphocyte percentage of white cells; LUSC cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg02423579 chr7:2872169 GNA12 -0.4 -6.19 -0.32 1.72e-9 Height; LUSC cis rs7131987 0.650 rs3782509 chr12:29453778 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.58 -0.34 1.84e-10 QT interval; LUSC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg10792982 chr14:105748885 BRF1 0.52 9.44 0.46 6.49e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs9470366 0.545 rs2395655 chr6:36645696 C/T cg24425727 chr6:36645648 CDKN1A 0.29 6.19 0.32 1.8e-9 QRS duration; LUSC cis rs2235642 0.785 rs1057983 chr16:1660274 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.33 7.73 0.39 1.29e-13 Coronary artery disease; LUSC cis rs6967385 0.900 rs10155958 chr7:12367943 T/G cg06484146 chr7:12443880 VWDE 0.4 5.84 0.3 1.21e-8 Response to taxane treatment (placlitaxel); LUSC cis rs73206853 0.841 rs73194013 chr12:111100677 T/C cg12870014 chr12:110450643 ANKRD13A 0.71 7.16 0.36 5.01e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2652834 0.851 rs2729815 chr15:63412843 A/G cg05507819 chr15:63340323 TPM1 0.46 5.97 0.31 6.09e-9 HDL cholesterol; LUSC cis rs7538876 0.787 rs57142672 chr1:17744536 A/G cg07965774 chr1:17746286 RCC2 0.32 5.98 0.31 5.88e-9 Basal cell carcinoma; LUSC trans rs10506458 1.000 rs1009539 chr12:63414655 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.17 15.85 0.66 1.35e-42 Hemostatic factors and hematological phenotypes; LUSC cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.52 5.95 0.31 6.75e-9 Schizophrenia; LUSC cis rs10761482 0.861 rs7909961 chr10:62165578 T/C cg18175470 chr10:62150864 ANK3 -0.58 -8.72 -0.43 1.34e-16 Schizophrenia; LUSC cis rs8078723 0.714 rs3785550 chr17:38149727 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.37 0.37 1.39e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs67478160 0.584 rs2295148 chr14:104195610 T/C cg08213375 chr14:104286397 PPP1R13B 0.43 8.32 0.41 2.31e-15 Schizophrenia; LUSC cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg22117172 chr7:91764530 CYP51A1 0.31 5.69 0.3 2.76e-8 Breast cancer; LUSC cis rs7408868 1.000 rs10407320 chr19:15275716 G/C cg14696996 chr19:15285081 NOTCH3 1.02 9.38 0.46 1.03e-18 Pulse pressure; LUSC cis rs17685 0.753 rs1637039 chr7:75693009 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.64 -0.39 2.3e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4243830 0.850 rs6679649 chr1:6606608 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.82 10.51 0.5 1.63e-22 Body mass index; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg22987389 chr8:22428557 SORBS3 -0.44 -6.61 -0.34 1.55e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs28735056 0.563 rs12968139 chr18:77685520 A/G cg20368463 chr18:77673604 PQLC1 -0.71 -10.96 -0.51 4.56e-24 Schizophrenia; LUSC cis rs11997175 0.646 rs4463379 chr8:33692719 G/A ch.8.33884649F chr8:33765107 NA 0.45 6.71 0.34 8.6e-11 Body mass index; LUSC trans rs853679 0.546 rs200952 chr6:27836976 C/T cg06606381 chr12:133084897 FBRSL1 -0.8 -7.62 -0.38 2.63e-13 Depression; LUSC cis rs61931739 0.500 rs11053167 chr12:34387092 A/C cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.75e-9 Morning vs. evening chronotype; LUSC cis rs929354 0.806 rs28446734 chr7:156996775 T/C cg17757837 chr7:157058334 UBE3C 0.84 13.51 0.59 1.71e-33 Body mass index; LUSC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg18876405 chr7:65276391 NA 0.58 9.4 0.46 9.19e-19 Aortic root size; LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.74 0.43 1.12e-16 Prudent dietary pattern; LUSC cis rs7100689 0.646 rs1538823 chr10:82088040 C/A cg01528321 chr10:82214614 TSPAN14 0.82 12.33 0.56 4.69e-29 Post bronchodilator FEV1; LUSC cis rs9300255 0.602 rs2851438 chr12:123643689 T/C cg00376283 chr12:123451042 ABCB9 0.67 8.42 0.42 1.1e-15 Neutrophil percentage of white cells; LUSC cis rs763121 0.853 rs5757181 chr22:39013522 G/A cg06022373 chr22:39101656 GTPBP1 0.76 11.75 0.54 6.21e-27 Menopause (age at onset); LUSC cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg02175503 chr12:58329896 NA 0.57 8.64 0.43 2.43e-16 Intelligence (multi-trait analysis); LUSC trans rs11258747 0.865 rs7910023 chr10:6468630 C/T cg04902529 chr1:4193806 NA 0.36 5.98 0.31 5.75e-9 Type 1 diabetes; LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg10729496 chr3:10149963 C3orf24 0.52 6.88 0.35 2.9100000000000002e-11 Alzheimer's disease; LUSC cis rs11250464 0.833 rs4554799 chr10:1407728 C/T cg08668359 chr10:1443807 ADARB2 0.4 6.09 0.32 3.19e-9 Radiation response; LUSC cis rs983392 0.679 rs1026254 chr11:60030457 A/G cg20284999 chr11:59952153 MS4A6A 0.36 6.02 0.31 4.68e-9 Alzheimer's disease (late onset); LUSC trans rs2392780 0.536 rs34628978 chr8:128336744 G/A cg10195415 chr17:73887371 TRIM65 0.4 6.37 0.33 6.34e-10 Breast cancer (early onset); LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg21435336 chr19:17392852 ANKLE1 0.43 6.09 0.32 3.08e-9 Systemic lupus erythematosus; LUSC trans rs3857536 0.813 rs1029399 chr6:66952476 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -5.99 -0.31 5.34e-9 Blood trace element (Cu levels); LUSC trans rs10435719 0.834 rs6985792 chr8:11795335 T/C cg08975724 chr8:8085496 FLJ10661 0.48 7.0 0.36 1.44e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs877282 1.000 rs34257857 chr10:772993 C/A cg22713356 chr15:30763199 NA 1.08 15.38 0.64 9.93e-41 Uric acid levels; LUSC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.35 -0.8 4.97e-76 Height; LUSC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg11812906 chr14:75593930 NEK9 -0.67 -11.65 -0.54 1.43e-26 Height; LUSC trans rs7824557 0.564 rs4631424 chr8:11236809 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.19e-14 Retinal vascular caliber; LUSC cis rs2120019 0.567 rs68036747 chr15:75203200 A/C cg17294928 chr15:75287854 SCAMP5 -0.75 -8.75 -0.43 1.07e-16 Blood trace element (Zn levels); LUSC cis rs7000551 0.659 rs2280521 chr8:22271995 G/T cg12081754 chr8:22256438 SLC39A14 -0.53 -6.87 -0.35 3.07e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg01475377 chr6:109611718 NA -0.43 -7.83 -0.39 6.39e-14 Reticulocyte fraction of red cells; LUSC trans rs7819412 0.521 rs10100660 chr8:11038885 T/A cg06636001 chr8:8085503 FLJ10661 -0.52 -7.28 -0.37 2.41e-12 Triglycerides; LUSC cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg23093090 chr10:104574429 C10orf26 -0.4 -7.38 -0.37 1.24e-12 Arsenic metabolism; LUSC cis rs11098499 0.722 rs7673476 chr4:120248683 C/T cg24375607 chr4:120327624 NA 0.73 11.45 0.53 7.91e-26 Corneal astigmatism; LUSC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg00343986 chr7:65444356 GUSB 0.48 7.14 0.36 5.8e-12 Aortic root size; LUSC cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg18132916 chr6:79620363 NA -0.38 -5.74 -0.3 2.18e-8 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg05025164 chr4:1340916 KIAA1530 0.38 5.72 0.3 2.33e-8 Obesity-related traits; LUSC cis rs12579753 0.912 rs4417392 chr12:82158722 C/A cg07988820 chr12:82153109 PPFIA2 -0.45 -6.68 -0.34 9.94e-11 Resting heart rate; LUSC cis rs4595586 0.545 rs12831116 chr12:39401456 C/T cg13010199 chr12:38710504 ALG10B 0.45 6.35 0.33 6.97e-10 Morning vs. evening chronotype; LUSC cis rs6908843 0.532 rs9459624 chr6:166671008 T/C cg06878426 chr6:166666287 NA 0.42 6.15 0.32 2.25e-9 Macrophage inflammatory protein 1b levels; LUSC cis rs7107174 0.901 rs10899498 chr11:78124575 C/G cg02023728 chr11:77925099 USP35 0.42 6.24 0.32 1.35e-9 Testicular germ cell tumor; LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.7e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs68170813 0.599 rs12532514 chr7:107000952 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.65 -0.47 1.34e-19 Coronary artery disease; LUSC cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg05347473 chr6:146136440 FBXO30 0.52 8.84 0.44 5.74e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs17604090 0.938 rs850027 chr7:29675792 G/T cg19413766 chr7:29689036 LOC646762 -0.58 -6.89 -0.35 2.76e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs4654899 0.802 rs935918 chr1:21145660 C/T cg01072550 chr1:21505969 NA -0.46 -6.84 -0.35 3.81e-11 Superior frontal gyrus grey matter volume; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg16031515 chr1:205743344 RAB7L1 0.29 6.37 0.33 6.15e-10 Menarche (age at onset); LUSC cis rs8017423 0.967 rs2151748 chr14:90694897 G/C cg04374321 chr14:90722782 PSMC1 0.71 11.22 0.52 5.33e-25 Mortality in heart failure; LUSC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg10523679 chr1:76189770 ACADM 0.88 14.1 0.61 9.28e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10489202 0.657 rs3767478 chr1:168069626 G/A cg24449463 chr1:168025552 DCAF6 -0.68 -10.19 -0.49 2.04e-21 Schizophrenia; LUSC cis rs1448094 0.874 rs10779219 chr12:86322643 T/G cg18827107 chr12:86230957 RASSF9 -0.41 -5.99 -0.31 5.43e-9 Major depressive disorder; LUSC cis rs3806843 1.000 rs10477033 chr5:140169603 G/C cg26395211 chr5:140044315 WDR55 -0.38 -5.83 -0.3 1.28e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1023500 0.573 rs8135801 chr22:42475568 A/G cg15557168 chr22:42548783 NA 0.45 6.85 0.35 3.47e-11 Schizophrenia; LUSC cis rs9914988 0.943 rs11652272 chr17:27167973 C/G cg14438399 chr17:27053147 TLCD1 0.54 5.91 0.31 8.3e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9287719 0.649 rs12473957 chr2:10717714 C/G cg00105475 chr2:10696890 NA -0.36 -6.08 -0.32 3.35e-9 Prostate cancer; LUSC cis rs1267303 0.562 rs2476162 chr1:47007324 G/A cg25110126 chr1:46999211 NA 0.71 10.13 0.48 3.36e-21 Monobrow; LUSC cis rs28374715 0.733 rs7167706 chr15:41569644 C/A cg18705301 chr15:41695430 NDUFAF1 -0.99 -19.05 -0.72 2.83e-55 Ulcerative colitis; LUSC cis rs1577917 0.958 rs11755864 chr6:86691791 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.39 -0.42 1.35e-15 Response to antipsychotic treatment; LUSC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.84 -0.35 3.9e-11 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg21535247 chr6:8435926 SLC35B3 0.58 9.13 0.45 6.72e-18 Motion sickness; LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.03 -0.31 4.23e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11958404 0.932 rs6870420 chr5:157437166 T/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs9902453 0.904 rs7213076 chr17:28419428 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -10.95 -0.51 4.72e-24 Coffee consumption (cups per day); LUSC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg11764359 chr7:65958608 NA 0.7 10.57 0.5 1.02e-22 Aortic root size; LUSC cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.4 -6.31 -0.33 8.95e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg07677032 chr17:61819896 STRADA 0.54 9.07 0.44 1.05e-17 Prudent dietary pattern; LUSC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC trans rs853679 0.517 rs9380060 chr6:28132603 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs9547692 1.000 rs9547692 chr13:37473243 A/C cg01493522 chr13:37497338 NA -0.44 -6.3 -0.33 9.24e-10 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22801127 chr1:93544761 MTF2 -0.47 -7.13 -0.36 6.25e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3771570 1.000 rs55634485 chr2:242268994 T/C cg21155796 chr2:242212141 HDLBP 0.63 6.86 0.35 3.32e-11 Prostate cancer; LUSC cis rs72781680 1.000 rs72796316 chr2:24132272 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg05368731 chr17:41323189 NBR1 0.93 16.11 0.66 1.32e-43 Menopause (age at onset); LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg11766577 chr21:47581405 C21orf56 0.57 8.92 0.44 3.18e-17 Testicular germ cell tumor; LUSC cis rs11098499 0.738 rs28408407 chr4:120376030 C/G cg24375607 chr4:120327624 NA 0.77 11.58 0.54 2.78e-26 Corneal astigmatism; LUSC cis rs854765 0.583 rs12603148 chr17:17865257 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.48 0.59 2.2e-33 Total body bone mineral density; LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.27 5.96 0.31 6.29e-9 Electroencephalogram traits; LUSC cis rs2486288 0.656 rs62026703 chr15:45569929 G/T cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.84 -0.51 1.2e-23 Glomerular filtration rate; LUSC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs6977940 0.558 rs117222922 chr7:2891608 G/A cg19346786 chr7:2764209 NA 0.53 5.76 0.3 1.93e-8 White matter integrity; LUSC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg17279839 chr7:150038598 RARRES2 0.49 7.44 0.38 8.59e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg19812747 chr11:111475976 SIK2 -0.57 -8.47 -0.42 7.76e-16 Primary sclerosing cholangitis; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg03395511 chr6:291903 DUSP22 -0.7 -11.69 -0.54 1.03e-26 Menopause (age at onset); LUSC cis rs4319547 0.656 rs4997380 chr12:122838956 A/G cg23029597 chr12:123009494 RSRC2 -0.69 -8.97 -0.44 2.24e-17 Body mass index; LUSC cis rs7043114 0.525 rs10820969 chr9:95106678 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.72 -0.35 7.86e-11 Height; LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg11494091 chr17:61959527 GH2 0.63 13.42 0.59 3.77e-33 Prudent dietary pattern; LUSC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg08859206 chr1:53392774 SCP2 -0.43 -7.3 -0.37 2.09e-12 Monocyte count; LUSC cis rs9326248 0.581 rs7120963 chr11:116830261 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.59 -8.97 -0.44 2.22e-17 Blood protein levels; LUSC cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg08999081 chr20:33150536 PIGU 0.37 6.82 0.35 4.16e-11 Height; LUSC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg20203395 chr5:56204925 C5orf35 -0.78 -10.32 -0.49 7.47e-22 Initial pursuit acceleration; LUSC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg19920283 chr7:105172520 RINT1 0.58 6.11 0.32 2.71e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1832871 0.683 rs9457224 chr6:158666139 C/T cg07165851 chr6:158734300 TULP4 0.5 7.61 0.38 2.81e-13 Height; LUSC cis rs10927875 0.632 rs4661667 chr1:16162731 C/T cg21385522 chr1:16154831 NA -1.02 -20.61 -0.75 1.73e-61 Dilated cardiomyopathy; LUSC cis rs12760731 0.623 rs10798604 chr1:178254568 A/G cg00404053 chr1:178313656 RASAL2 -0.45 -5.9 -0.31 8.86e-9 Obesity-related traits; LUSC cis rs6987853 0.933 rs2923424 chr8:42382222 A/G cg09913449 chr8:42400586 C8orf40 -0.49 -8.1 -0.41 1.07e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs12295403 0.691 rs12808591 chr11:18677311 G/A cg09887367 chr11:18690185 NA -0.34 -6.87 -0.35 3.13e-11 Ovarian reserve; LUSC cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg24692254 chr21:30365293 RNF160 -0.51 -7.42 -0.38 9.63e-13 Dental caries; LUSC cis rs1403694 0.669 rs10440056 chr3:186433822 C/T cg12454167 chr3:186435060 KNG1 0.34 8.38 0.42 1.49e-15 Blood protein levels; LUSC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg19622623 chr12:86230825 RASSF9 -0.42 -6.01 -0.31 4.85e-9 Major depressive disorder; LUSC cis rs3106136 0.527 rs2883 chr4:95158610 A/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.36 -0.42 1.67e-15 Capecitabine sensitivity; LUSC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg07424592 chr7:64974309 NA -0.63 -5.65 -0.3 3.53e-8 Diabetic kidney disease; LUSC cis rs1577917 0.771 rs7452605 chr6:86240951 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.68 10.82 0.51 1.33e-23 Response to antipsychotic treatment; LUSC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg03609598 chr5:56110824 MAP3K1 -0.42 -6.21 -0.32 1.57e-9 Initial pursuit acceleration; LUSC cis rs2011503 0.882 rs10401714 chr19:19363630 G/A cg22782873 chr19:19639568 YJEFN3 -0.47 -5.7 -0.3 2.59e-8 Bipolar disorder; LUSC cis rs6430585 0.646 rs1057031 chr2:136633962 G/A cg07169764 chr2:136633963 MCM6 1.24 19.91 0.74 1.02e-58 Corneal structure; LUSC cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg18252515 chr7:66147081 NA -1.19 -12.75 -0.57 1.35e-30 Diabetic kidney disease; LUSC trans rs61931739 0.500 rs11053223 chr12:34481947 T/A cg26384229 chr12:38710491 ALG10B 0.9 15.7 0.65 5.49e-42 Morning vs. evening chronotype; LUSC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg25039879 chr17:56429692 SUPT4H1 0.66 8.82 0.43 6.62e-17 Cognitive test performance; LUSC cis rs12286929 1.000 rs12286929 chr11:115022404 A/G cg04055981 chr11:115044050 NA 0.36 6.28 0.33 1.02e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg13560548 chr3:10150139 C3orf24 0.47 6.6 0.34 1.58e-10 Alzheimer's disease; LUSC cis rs9300255 0.543 rs1260294 chr12:123560289 T/C cg05973401 chr12:123451056 ABCB9 -0.51 -5.69 -0.3 2.8e-8 Neutrophil percentage of white cells; LUSC trans rs2235573 0.527 rs5756853 chr22:38329524 G/A cg19894588 chr14:64061835 NA -0.53 -7.5 -0.38 5.74e-13 Glioblastoma;Glioma; LUSC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs11229555 1.000 rs7102510 chr11:58371283 T/G cg15696309 chr11:58395628 NA -0.69 -9.27 -0.45 2.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg05729581 chr11:3078854 CARS -0.51 -7.32 -0.37 1.91e-12 Longevity; LUSC cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg04727924 chr7:799746 HEATR2 -0.55 -6.75 -0.35 6.66e-11 Cerebrospinal P-tau181p levels; LUSC cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg11266682 chr4:10021025 SLC2A9 0.49 9.04 0.44 1.26e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9325144 0.647 rs61930266 chr12:38922048 A/G cg26384229 chr12:38710491 ALG10B -0.61 -9.36 -0.46 1.17e-18 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC cis rs12421382 0.507 rs10890995 chr11:109327622 A/G cg27471124 chr11:109292789 C11orf87 -0.55 -10.09 -0.48 4.63e-21 Schizophrenia; LUSC cis rs2688608 0.901 rs2664280 chr10:75617344 A/T cg17411546 chr10:75410026 SYNPO2L 0.43 6.15 0.32 2.24e-9 Inflammatory bowel disease; LUSC cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg06627557 chr7:32535165 LSM5;AVL9 1.08 20.95 0.75 7.86e-63 Cognitive ability; LUSC cis rs34779708 0.897 rs4934529 chr10:35302376 T/A cg04310649 chr10:35416472 CREM -0.42 -6.39 -0.33 5.5e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg25554036 chr4:6271136 WFS1 0.59 12.15 0.55 2.29e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs4729127 0.708 rs17166230 chr7:94017794 G/C cg19058453 chr19:9879420 ZNF846 0.62 6.17 0.32 1.99e-9 Intelligence; LUSC cis rs61931739 0.500 rs7979482 chr12:34542877 C/A cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs3849570 0.695 rs6804587 chr3:81873423 T/C cg07356753 chr3:81810745 GBE1 -0.59 -8.78 -0.43 8.46e-17 Waist circumference;Body mass index; LUSC cis rs12220238 0.818 rs16931294 chr10:75999169 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.78 0.39 8.92e-14 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs10843647 1.000 rs973484 chr12:30326090 A/G cg12718339 chr12:29936407 TMTC1 -0.35 -5.84 -0.3 1.27e-8 Glucose homeostasis traits; LUSC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg00033643 chr7:134001901 SLC35B4 0.43 6.67 0.34 1.04e-10 Mean platelet volume; LUSC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg14703610 chr5:56206110 C5orf35 0.41 6.02 0.31 4.48e-9 Coronary artery disease; LUSC cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg05343316 chr1:45956843 TESK2 0.73 9.92 0.48 1.64e-20 Platelet count; LUSC cis rs1865760 0.892 rs6456705 chr6:25936056 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 6.46 0.33 3.67e-10 Height; LUSC trans rs2786098 0.656 rs12747786 chr1:197565832 T/C cg16005942 chr6:160526640 IGF2R 0.5 6.02 0.31 4.61e-9 Asthma; LUSC cis rs10782582 0.609 rs1628063 chr1:76391646 A/G cg03433033 chr1:76189801 ACADM -0.39 -5.77 -0.3 1.85e-8 Daytime sleep phenotypes; LUSC cis rs12145833 0.596 rs12043646 chr1:243281992 G/A cg02356786 chr1:243265016 LOC731275 0.69 6.48 0.33 3.38e-10 Obesity (early onset extreme); LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg15242686 chr22:24348715 GSTTP1 -0.53 -8.4 -0.42 1.3e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg13319975 chr6:146136371 FBXO30 -0.51 -7.65 -0.39 2.16e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7267979 0.744 rs6050464 chr20:25209299 C/A cg08601574 chr20:25228251 PYGB 0.57 9.13 0.45 6.57e-18 Liver enzyme levels (alkaline phosphatase); LUSC cis rs231513 0.954 rs231510 chr17:41966470 T/C cg26893861 chr17:41843967 DUSP3 -0.51 -6.13 -0.32 2.44e-9 Cognitive function; LUSC cis rs977987 0.778 rs2113232 chr16:75391185 T/C cg04384234 chr16:75411784 CFDP1 -0.4 -6.6 -0.34 1.64e-10 Dupuytren's disease; LUSC cis rs11971779 0.648 rs9656512 chr7:139054046 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs6952809 0.532 rs10272548 chr7:2439467 G/A cg23289794 chr7:2394357 EIF3B -0.76 -9.99 -0.48 9.5e-21 Multiple sclerosis; LUSC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg05082376 chr22:42548792 NA -0.44 -6.82 -0.35 4.16e-11 Schizophrenia; LUSC cis rs9517320 0.935 rs9645891 chr13:99126800 A/G cg07423050 chr13:99094983 FARP1 0.34 6.46 0.33 3.69e-10 Longevity; LUSC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg05347473 chr6:146136440 FBXO30 0.46 7.66 0.39 1.98e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg05340658 chr4:99064831 C4orf37 0.66 11.31 0.53 2.51e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6430585 0.528 rs56064699 chr2:136595706 G/A cg07169764 chr2:136633963 MCM6 1.21 18.28 0.71 3.2e-52 Corneal structure; LUSC cis rs7267979 1.000 rs6050566 chr20:25351071 G/A cg08601574 chr20:25228251 PYGB -0.43 -6.67 -0.34 1.04e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7296418 0.663 rs28450974 chr12:123861420 G/A cg13010344 chr12:123464640 ARL6IP4 -0.51 -8.12 -0.41 8.81e-15 Platelet count; LUSC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg00933542 chr6:150070202 PCMT1 0.33 6.79 0.35 5.03e-11 Lung cancer; LUSC cis rs4727027 0.704 rs12537763 chr7:148903984 G/A cg23158103 chr7:148848205 ZNF398 -0.49 -8.32 -0.41 2.29e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9640161 0.659 rs59572505 chr7:150014986 C/T cg10018233 chr7:150070692 REPIN1 0.34 6.01 0.31 4.96e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs9611565 0.512 rs5758464 chr22:42171300 A/G cg06634786 chr22:41940651 POLR3H 0.53 5.72 0.3 2.31e-8 Vitiligo; LUSC cis rs7408868 0.908 rs4809028 chr19:15273231 A/G cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.1e-18 Pulse pressure; LUSC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg04414720 chr1:150670196 GOLPH3L -0.49 -7.75 -0.39 1.1e-13 Tonsillectomy; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg07332563 chr6:291687 DUSP22 -0.49 -7.41 -0.38 1.03e-12 Menopause (age at onset); LUSC cis rs9427116 0.502 rs9426827 chr1:154589965 T/C cg17218026 chr1:154582156 ADAR 0.56 10.01 0.48 8.47e-21 Blood protein levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02473084 chr2:37551451 NA -0.53 -6.39 -0.33 5.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs11190604 1.000 rs2495750 chr10:102327708 A/G cg16342193 chr10:102329863 NA -0.38 -6.44 -0.33 4.28e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2050392 0.630 rs303427 chr10:30739780 G/A cg18806716 chr10:30721971 MAP3K8 -0.49 -7.77 -0.39 9.54e-14 Inflammatory bowel disease; LUSC cis rs6542838 0.611 rs13006398 chr2:99522323 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.53 -7.07 -0.36 9.32e-12 Fear of minor pain; LUSC trans rs7937682 0.883 rs568506 chr11:111466429 C/T cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs10791323 0.572 rs1114367 chr11:133737304 G/T cg00579200 chr11:133705235 NA -0.41 -5.9 -0.31 8.94e-9 Childhood ear infection; LUSC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg08847533 chr14:75593920 NEK9 -0.83 -15.25 -0.64 3.16e-40 Height; LUSC cis rs7089973 0.604 rs61596353 chr10:116597763 T/C cg03647239 chr10:116582469 FAM160B1 0.44 7.16 0.36 5.24e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg25427524 chr10:38739819 LOC399744 0.44 7.46 0.38 7.39e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10751667 1.000 rs10751667 chr11:941941 A/T ch.11.42038R chr11:967971 AP2A2 0.53 7.88 0.4 4.59e-14 Alzheimer's disease (late onset); LUSC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg05585544 chr11:47624801 NA -0.42 -7.32 -0.37 1.85e-12 Subjective well-being; LUSC cis rs6543140 0.964 rs6543136 chr2:103065547 G/A cg09003973 chr2:102972529 NA 0.55 7.1 0.36 7.72e-12 Blood protein levels; LUSC cis rs9479482 0.648 rs912557 chr6:150385977 C/T cg25797454 chr6:150327115 RAET1K 0.29 6.49 0.33 3.08e-10 Alopecia areata; LUSC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg26395211 chr5:140044315 WDR55 0.45 7.0 0.36 1.39e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs300703 0.872 rs300752 chr2:209292 A/G cg21211680 chr2:198530 NA 0.68 7.31 0.37 2e-12 Blood protein levels; LUSC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11644478 chr21:40555479 PSMG1 -0.65 -10.0 -0.48 8.86e-21 Menarche (age at onset); LUSC cis rs4820539 0.966 rs2267005 chr22:23461723 A/G cg21100191 chr22:23484243 RTDR1 0.91 15.59 0.65 1.42e-41 Bone mineral density; LUSC cis rs4795519 0.557 rs12451105 chr17:22179841 T/A cg22648282 chr17:21454238 C17orf51 -0.42 -5.7 -0.3 2.69e-8 Chronic myeloid leukemia; LUSC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg07395648 chr5:131743802 NA -0.38 -5.67 -0.3 3.14e-8 Blood metabolite levels; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg07177001 chr8:22926478 TNFRSF10B 0.69 6.18 0.32 1.91e-9 Body mass index; LUSC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg06481639 chr22:41940642 POLR3H 0.49 5.85 0.3 1.19e-8 Vitiligo; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18484294 chr2:202645530 ALS2 0.45 6.13 0.32 2.52e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2795502 1.000 rs2744090 chr10:43339614 G/C cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1729951 0.575 rs361245 chr3:136695706 A/G cg12473912 chr3:136751656 NA 0.37 6.44 0.33 4.2e-10 Neuroticism; LUSC trans rs877282 0.945 rs11599043 chr10:777972 C/T cg13042288 chr15:90349979 ANPEP -0.49 -7.25 -0.37 2.9e-12 Uric acid levels; LUSC cis rs1965732 0.917 rs9750735 chr2:3708383 A/T cg10645314 chr2:3704589 ALLC -0.37 -6.49 -0.33 3.16e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg25288140 chr17:41278341 BRCA1;NBR2 0.4 6.18 0.32 1.89e-9 Menopause (age at onset); LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg11645453 chr3:52864694 ITIH4 0.35 7.93 0.4 3.28e-14 Bipolar disorder; LUSC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg05754148 chr16:3507555 NAT15 -0.8 -9.27 -0.45 2.45e-18 Tuberculosis; LUSC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.47e-9 Bipolar disorder; LUSC cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg19875535 chr5:140030758 IK -0.54 -8.91 -0.44 3.48e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs11785400 0.793 rs4457308 chr8:143733922 G/A cg10596483 chr8:143751796 JRK 0.53 7.58 0.38 3.35e-13 Schizophrenia; LUSC cis rs977987 0.806 rs2865531 chr16:75390316 T/A cg03315344 chr16:75512273 CHST6 0.5 9.62 0.47 1.68e-19 Dupuytren's disease; LUSC cis rs6546886 0.912 rs10168410 chr2:74294110 A/T cg14702570 chr2:74259524 NA -0.31 -5.83 -0.3 1.32e-8 Dialysis-related mortality; LUSC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg14262678 chr6:151773367 RMND1;C6orf211 -0.45 -7.14 -0.36 6.03e-12 Menarche (age at onset); LUSC cis rs10419226 0.555 rs876982 chr19:18782377 C/T cg22001208 chr19:18782374 NA 0.37 6.36 0.33 6.75e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03720838 chr6:90529562 MDN1 -0.41 -5.97 -0.31 6.07e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4664308 0.935 rs4520994 chr2:160937750 G/A cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg11752832 chr7:134001865 SLC35B4 0.53 8.04 0.4 1.59e-14 Mean platelet volume; LUSC cis rs34779708 0.931 rs35886556 chr10:35334985 C/T cg04310649 chr10:35416472 CREM -0.4 -6.05 -0.31 3.86e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7829975 0.684 rs546603 chr8:8595838 T/G cg08975724 chr8:8085496 FLJ10661 -0.42 -5.83 -0.3 1.3e-8 Mood instability; LUSC cis rs10986311 1.000 rs748741 chr9:127089775 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.37 5.9 0.31 9.14e-9 Vitiligo; LUSC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg18225595 chr11:63971243 STIP1 0.5 6.11 0.32 2.79e-9 Mean platelet volume; LUSC cis rs709400 0.627 rs55859054 chr14:103953666 T/A cg12935359 chr14:103987150 CKB -0.49 -7.4 -0.38 1.14e-12 Body mass index; LUSC cis rs240764 0.658 rs2050549 chr6:101216645 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.26 -0.32 1.21e-9 Neuroticism; LUSC cis rs2637266 0.597 rs846622 chr10:78543005 G/A cg18941641 chr10:78392320 NA 0.39 7.15 0.36 5.46e-12 Pulmonary function; LUSC cis rs2286885 1.000 rs2286885 chr9:129246487 A/C cg15282417 chr9:129245246 FAM125B 0.38 6.34 0.33 7.26e-10 Intraocular pressure; LUSC cis rs3771570 0.786 rs62186378 chr2:242211554 G/A cg21155796 chr2:242212141 HDLBP 0.69 7.65 0.39 2.1e-13 Prostate cancer; LUSC cis rs524023 0.957 rs538737 chr11:64355772 C/G cg07220939 chr11:64358617 SLC22A12 0.23 5.88 0.31 9.83e-9 Urate levels in obese individuals; LUSC cis rs748404 0.697 rs574065 chr15:43550655 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.52 -8.29 -0.41 2.71e-15 Lung cancer; LUSC trans rs3785574 0.927 rs2727313 chr17:61961914 A/G cg09060275 chr22:27053596 MIAT -0.4 -6.16 -0.32 2.14e-9 Height; LUSC cis rs34375054 0.525 rs7136220 chr12:125602684 T/C cg06287003 chr12:125626642 AACS -0.39 -6.75 -0.35 6.73e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7824557 0.527 rs4631425 chr8:11239054 C/T cg21775007 chr8:11205619 TDH -0.64 -10.41 -0.49 3.61e-22 Retinal vascular caliber; LUSC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.19 0.37 4.16e-12 Tonsillectomy; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.56 -8.75 -0.43 1.1e-16 Lymphocyte counts; LUSC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.27 -0.32 1.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg16405210 chr4:1374714 KIAA1530 0.7 10.91 0.51 6.78e-24 Obesity-related traits; LUSC cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg25208724 chr1:156163844 SLC25A44 1.01 17.3 0.69 2.6e-48 Testicular germ cell tumor; LUSC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg13126279 chr21:47581558 C21orf56 -0.48 -7.33 -0.37 1.75e-12 Testicular germ cell tumor; LUSC cis rs11112613 0.713 rs2374502 chr12:105938939 T/C cg03607813 chr12:105948248 NA 0.78 11.93 0.55 1.39e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg10356904 chr22:49881777 NA -0.32 -7.08 -0.36 8.51e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4423214 1.000 rs2040323 chr11:71172783 A/C cg05163923 chr11:71159392 DHCR7 0.76 11.28 0.53 3.28e-25 Vitamin D levels; LUSC cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg11752832 chr7:134001865 SLC35B4 -0.5 -7.34 -0.37 1.66e-12 Mean platelet volume; LUSC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg19346786 chr7:2764209 NA -0.45 -7.5 -0.38 6e-13 Height; LUSC cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg14458575 chr2:238380390 NA 0.88 15.45 0.65 5.08e-41 Prostate cancer; LUSC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg07636037 chr3:49044803 WDR6 0.98 15.22 0.64 4.11e-40 Parkinson's disease; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg19318889 chr4:1322082 MAEA 0.42 6.94 0.36 2.02e-11 Obesity-related traits; LUSC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg23625390 chr15:77176239 SCAPER -0.48 -7.28 -0.37 2.43e-12 Blood metabolite levels; LUSC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -12.3 -0.56 5.96e-29 Hemoglobin concentration; LUSC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs2235544 0.565 rs634532 chr1:54468947 G/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.91 0.31 8.4e-9 Lung cancer; LUSC cis rs8114671 0.935 rs945960 chr20:33762854 A/G cg07148914 chr20:33460835 GGT7 0.47 6.93 0.35 2.22e-11 Height; LUSC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.01 0.52 2.98e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs3857536 0.706 rs2157963 chr6:66945449 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs9905704 0.918 rs654743 chr17:56736490 T/C cg12560992 chr17:57184187 TRIM37 0.55 7.85 0.39 5.74e-14 Testicular germ cell tumor; LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg14552801 chr7:65878734 NA 0.38 5.81 0.3 1.42e-8 Aortic root size; LUSC cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 8.16e-15 Axial length; LUSC cis rs854765 0.618 rs8068820 chr17:17834119 A/G cg09796270 chr17:17721594 SREBF1 0.42 7.51 0.38 5.43e-13 Total body bone mineral density; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.75 0.43 1.1e-16 Prudent dietary pattern; LUSC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18404041 chr3:52824283 ITIH1 -0.57 -10.9 -0.51 7.31e-24 Bipolar disorder; LUSC cis rs4363385 0.574 rs61813182 chr1:152943868 T/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.76 -0.3 1.87e-8 Inflammatory skin disease; LUSC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg20503657 chr10:835505 NA 0.99 13.86 0.6 8.34e-35 Eosinophil percentage of granulocytes; LUSC cis rs2147959 0.883 rs7529055 chr1:228636824 T/G cg18477163 chr1:228402036 OBSCN -0.43 -5.96 -0.31 6.29e-9 Adult asthma; LUSC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg11764359 chr7:65958608 NA 0.7 10.95 0.51 4.71e-24 Aortic root size; LUSC cis rs36093844 0.752 rs17817308 chr11:85593529 G/A cg16165120 chr11:85566439 CCDC83 -0.39 -5.65 -0.3 3.42e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6500602 0.592 rs3747585 chr16:4519140 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.64 8.18 0.41 6e-15 Schizophrenia; LUSC trans rs11098499 0.865 rs28753180 chr4:120405367 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 4.01e-10 Corneal astigmatism; LUSC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg20243544 chr17:37824526 PNMT 0.53 7.55 0.38 4.15e-13 Asthma; LUSC cis rs748404 0.697 rs513970 chr15:43579566 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.57 8.9 0.44 3.51e-17 Lung cancer; LUSC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.65 10.26 0.49 1.22e-21 Body mass index (adult); LUSC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.81 -0.3 1.43e-8 Total body bone mineral density; LUSC cis rs2075371 0.501 rs1643057 chr7:134027521 A/G cg20476274 chr7:133979776 SLC35B4 0.69 11.67 0.54 1.29e-26 Mean platelet volume; LUSC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg12292205 chr6:26970375 C6orf41 0.5 8.5 0.42 6.55e-16 Schizophrenia; LUSC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg23985595 chr17:80112537 CCDC57 -0.3 -5.75 -0.3 2.05e-8 Blood metabolite levels; LUSC cis rs13242816 1.000 rs67652573 chr7:116109958 T/C cg16553024 chr7:116138462 CAV2 -0.54 -5.92 -0.31 7.84e-9 P wave duration; LUSC cis rs12145833 0.596 rs1060643 chr1:243429976 G/C cg02356786 chr1:243265016 LOC731275 0.69 6.27 0.32 1.14e-9 Obesity (early onset extreme); LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg01973587 chr1:228161476 NA -0.41 -7.26 -0.37 2.71e-12 Diastolic blood pressure; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg07167872 chr1:205819463 PM20D1 0.5 8.35 0.42 1.88e-15 Menarche (age at onset); LUSC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg22823121 chr1:150693482 HORMAD1 0.62 9.51 0.46 3.97e-19 Tonsillectomy; LUSC cis rs10740039 0.516 rs2393645 chr10:62315027 C/T cg18175470 chr10:62150864 ANK3 -0.45 -6.78 -0.35 5.44e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10162002 0.935 rs9578603 chr13:24040733 C/G cg00158254 chr13:24040743 NA 0.52 5.8 0.3 1.55e-8 Hypothyroidism; LUSC cis rs2439831 0.850 rs3862142 chr15:44064806 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.37 0.49 5.04e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs12950390 0.814 rs4794099 chr17:45838358 T/C cg03474202 chr17:45855739 NA -0.28 -6.32 -0.33 8.45e-10 IgG glycosylation; LUSC cis rs6940638 0.688 rs9379960 chr6:27121325 A/C cg12292205 chr6:26970375 C6orf41 -0.38 -5.65 -0.3 3.37e-8 Intelligence (multi-trait analysis); LUSC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg22823121 chr1:150693482 HORMAD1 0.58 8.83 0.44 5.82e-17 Tonsillectomy; LUSC trans rs61931739 0.620 rs708143 chr12:33719962 A/C cg26384229 chr12:38710491 ALG10B 0.49 7.61 0.38 2.74e-13 Morning vs. evening chronotype; LUSC cis rs8027181 1.000 rs4776613 chr15:73080731 C/T cg25632853 chr15:73088954 NA 0.34 6.62 0.34 1.42e-10 Triglyceride levels; LUSC cis rs6121246 0.909 rs6060821 chr20:30294034 C/T cg13852791 chr20:30311386 BCL2L1 0.87 11.63 0.54 1.73e-26 Mean corpuscular hemoglobin; LUSC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg07424592 chr7:64974309 NA 0.64 5.72 0.3 2.34e-8 Diabetic kidney disease; LUSC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg07701084 chr6:150067640 NUP43 0.56 8.59 0.43 3.49e-16 Lung cancer; LUSC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg22431228 chr1:16359049 CLCNKA -0.33 -6.12 -0.32 2.57e-9 Dilated cardiomyopathy; LUSC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg01475377 chr6:109611718 NA -0.46 -8.37 -0.42 1.59e-15 Reticulocyte fraction of red cells; LUSC cis rs4805272 0.512 rs7245724 chr19:29341679 C/T cg12667521 chr19:29218732 NA 0.51 5.96 0.31 6.4e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg12432903 chr7:1882776 MAD1L1 -0.36 -5.69 -0.3 2.82e-8 Bipolar disorder and schizophrenia; LUSC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg06618935 chr21:46677482 NA -0.39 -7.93 -0.4 3.34e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7824557 0.583 rs2263512 chr8:11233419 T/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.13 -0.41 8.27e-15 Retinal vascular caliber; LUSC cis rs1953600 0.645 rs2819945 chr10:81952956 G/A cg00277334 chr10:82204260 NA 0.5 7.95 0.4 2.97e-14 Sarcoidosis; LUSC cis rs7833787 1.000 rs34270955 chr8:18705250 G/C cg17701159 chr8:18705777 PSD3 -0.39 -6.43 -0.33 4.52e-10 Obesity-related traits; LUSC cis rs208520 0.690 rs207082 chr6:66773796 G/A cg07460842 chr6:66804631 NA -1.11 -17.3 -0.69 2.55e-48 Exhaled nitric oxide output; LUSC cis rs2224391 0.628 rs2773317 chr6:5254509 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.51 -6.92 -0.35 2.37e-11 Height; LUSC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.1 0.41 1.04e-14 Bipolar disorder; LUSC cis rs4776059 1.000 rs17614559 chr15:52878719 G/A cg25063058 chr15:52860530 ARPP19 0.44 6.15 0.32 2.23e-9 Schizophrenia; LUSC cis rs2019216 0.564 rs907707 chr17:21910083 G/C cg22648282 chr17:21454238 C17orf51 -0.49 -7.36 -0.37 1.45e-12 Pelvic organ prolapse; LUSC cis rs4494114 1.000 rs6674910 chr1:39357157 C/T cg25970120 chr1:39325951 RRAGC 0.39 6.27 0.32 1.09e-9 Blood protein levels; LUSC cis rs7119167 0.686 rs7342249 chr11:73046299 T/C cg17517138 chr11:73019481 ARHGEF17 0.48 5.69 0.3 2.77e-8 Blood protein levels; LUSC cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg13902645 chr11:5959945 NA -0.64 -9.17 -0.45 5.06e-18 DNA methylation (variation); LUSC trans rs61931739 0.517 rs11611190 chr12:34015697 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.34 0.42 1.98e-15 Morning vs. evening chronotype; LUSC trans rs2386661 0.547 rs11259540 chr10:5646706 A/T cg11398623 chr21:37499189 NA 0.27 6.17 0.32 2.01e-9 Breast cancer; LUSC cis rs8062405 0.690 rs7187604 chr16:28565953 A/G cg16576597 chr16:28551801 NUPR1 0.34 6.91 0.35 2.4e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs7637701 0.713 rs9878566 chr3:156493213 C/T cg11006288 chr14:69012387 RAD51L1 0.39 6.23 0.32 1.41e-9 Breast cancer; LUSC cis rs7131987 0.650 rs7301188 chr12:29455391 C/T cg09582351 chr12:29534625 ERGIC2 -0.32 -6.51 -0.34 2.71e-10 QT interval; LUSC cis rs4988958 0.565 rs885088 chr2:103039044 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.04 0.36 1.12e-11 Asthma (childhood onset); LUSC cis rs1519814 1.000 rs7826920 chr8:121121010 T/C cg22335954 chr8:121166405 COL14A1 -0.41 -5.65 -0.3 3.44e-8 Breast cancer; LUSC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg12463550 chr7:65579703 CRCP 0.45 6.35 0.33 7.13e-10 Aortic root size; LUSC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg19774624 chr17:42201019 HDAC5 0.72 10.6 0.5 7.91e-23 Total body bone mineral density; LUSC cis rs6426558 0.572 rs2670471 chr1:227454328 T/C cg10327440 chr1:227177885 CDC42BPA 0.55 7.45 0.38 8.09e-13 Neutrophil percentage of white cells; LUSC cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg00074818 chr8:8560427 CLDN23 0.52 9.0 0.44 1.8e-17 Obesity-related traits; LUSC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg25427524 chr10:38739819 LOC399744 -0.67 -12.11 -0.55 3.2e-28 Extrinsic epigenetic age acceleration; LUSC cis rs9420 0.884 rs673344 chr11:57657141 G/A cg02958346 chr11:57425731 CLP1 0.43 5.99 0.31 5.3e-9 Schizophrenia; LUSC cis rs116988415 0.584 rs4902313 chr14:65242164 T/C cg25083366 chr14:65239357 SPTB 0.67 6.72 0.35 7.91e-11 Daytime sleep phenotypes; LUSC trans rs61931739 0.534 rs2636072 chr12:34062386 C/T cg26384229 chr12:38710491 ALG10B 0.7 11.02 0.52 2.75e-24 Morning vs. evening chronotype; LUSC cis rs3020736 0.500 rs6002604 chr22:42493081 A/T cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs9486719 1.000 rs2472882 chr6:96863474 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.9 0.48 2e-20 Migraine;Coronary artery disease; LUSC cis rs7107174 1.000 rs2511190 chr11:77988310 T/C cg02023728 chr11:77925099 USP35 0.48 6.81 0.35 4.5e-11 Testicular germ cell tumor; LUSC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg06877462 chr1:205807181 PM20D1 -0.47 -8.43 -0.42 1.07e-15 Menarche (age at onset); LUSC trans rs7939886 0.920 rs12223067 chr11:55915420 C/A cg03929089 chr4:120376271 NA 0.77 6.09 0.32 3.03e-9 Myopia (pathological); LUSC trans rs853679 0.607 rs67662114 chr6:27932301 G/A cg06606381 chr12:133084897 FBRSL1 -0.95 -8.54 -0.42 4.88e-16 Depression; LUSC cis rs6961069 0.585 rs17263407 chr7:80259908 G/C cg04458919 chr7:80252533 CD36 -0.41 -7.16 -0.36 5.25e-12 Platelet count; LUSC cis rs12548874 0.607 rs12543492 chr8:95891843 C/A cg09323728 chr8:95962352 TP53INP1 -0.37 -7.57 -0.38 3.65e-13 Hemoglobin concentration; LUSC cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9467603 0.800 rs28360585 chr6:25790356 A/T cg08501292 chr6:25962987 TRIM38 0.6 6.13 0.32 2.51e-9 Intelligence (multi-trait analysis); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg26664455 chr2:73298989 SFXN5 0.38 6.16 0.32 2.1e-9 Metabolite levels (Pyroglutamine); LUSC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.13 -0.41 8.74e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7312933 0.558 rs2178753 chr12:42732804 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.84 -0.35 3.72e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg02527881 chr3:46936655 PTH1R -0.36 -6.38 -0.33 5.97e-10 Colorectal cancer; LUSC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg23758822 chr17:41437982 NA 1.04 20.72 0.75 6.67e-62 Menopause (age at onset); LUSC cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg08807101 chr21:30365312 RNF160 -0.56 -8.5 -0.42 6.36e-16 Dental caries; LUSC cis rs6912958 0.558 rs7741825 chr6:88327338 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.43 -8.37 -0.42 1.63e-15 Monocyte percentage of white cells; LUSC cis rs61931739 0.857 rs999715 chr12:34143253 G/C cg06521331 chr12:34319734 NA -0.36 -6.22 -0.32 1.51e-9 Morning vs. evening chronotype; LUSC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.55 -0.38 4.21e-13 Aortic root size; LUSC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.54 0.5 1.33e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg12403142 chr1:92012408 NA -0.41 -6.66 -0.34 1.13e-10 Breast cancer; LUSC cis rs11997175 0.626 rs12155927 chr8:33789851 A/G ch.8.33884649F chr8:33765107 NA 0.42 6.37 0.33 6.35e-10 Body mass index; LUSC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg26879891 chr1:152191343 HRNR -0.37 -6.6 -0.34 1.65e-10 Inflammatory skin disease; LUSC cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.62e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg27535305 chr1:53392650 SCP2 0.52 10.04 0.48 6.43e-21 Monocyte count; LUSC cis rs1448094 1.000 rs7305284 chr12:86343786 C/T cg02569458 chr12:86230093 RASSF9 0.43 7.08 0.36 8.62e-12 Major depressive disorder; LUSC cis rs295140 1.000 rs1431766 chr2:201191034 A/G cg04283868 chr2:201171347 SPATS2L 0.42 6.33 0.33 7.7e-10 QT interval; LUSC cis rs2224391 0.628 rs2753239 chr6:5252826 C/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.37 -0.33 6.4e-10 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg22813821 chr12:72148853 RAB21 0.76 5.99 0.31 5.3e-9 Cognitive performance; LUSC cis rs300703 0.654 rs300771 chr2:117241 A/G cg21211680 chr2:198530 NA -0.75 -8.08 -0.4 1.18e-14 Blood protein levels; LUSC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg08219700 chr8:58056026 NA 0.56 6.75 0.35 6.65e-11 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg08888203 chr3:10149979 C3orf24 0.65 9.31 0.45 1.82e-18 Alzheimer's disease; LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.49 -0.59 2.14e-33 Alzheimer's disease; LUSC cis rs7923609 1.000 rs7923609 chr10:65133822 A/G cg01631684 chr10:65280961 REEP3 -0.38 -5.89 -0.31 9.58e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs3768617 0.510 rs6666259 chr1:183102855 T/C ch.1.3577855R chr1:183094577 LAMC1 0.73 11.13 0.52 1.08e-24 Fuchs's corneal dystrophy; LUSC cis rs4631830 0.863 rs6481329 chr10:51529746 G/A cg16070123 chr10:51489643 NA -0.5 -7.95 -0.4 2.83e-14 Prostate-specific antigen levels; LUSC cis rs6700896 0.931 rs10789192 chr1:66125770 G/A cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs7746199 0.736 rs35037868 chr6:27759115 G/C cg01620082 chr3:125678407 NA -0.81 -7.0 -0.36 1.37e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs2932538 0.583 rs2279500 chr1:113244433 T/C cg22162597 chr1:113214053 CAPZA1 -0.67 -7.42 -0.38 9.8e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs6012953 1.000 rs6091173 chr20:49134099 C/T cg13958625 chr20:49123093 NA 0.31 6.75 0.35 6.63e-11 Vitiligo; LUSC cis rs35146811 0.735 rs1727138 chr7:99815247 A/G cg13334819 chr7:99746414 C7orf59 0.5 6.69 0.34 9.48e-11 Coronary artery disease; LUSC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg03354898 chr7:1950403 MAD1L1 0.34 6.82 0.35 4.19e-11 Bipolar disorder and schizophrenia; LUSC cis rs3020736 0.500 rs5996109 chr22:42493098 A/G cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs6906287 0.647 rs3798420 chr6:118786486 T/C cg21191810 chr6:118973309 C6orf204 0.33 6.0 0.31 5.17e-9 Electrocardiographic conduction measures; LUSC cis rs6541297 1.000 rs4846838 chr1:230281618 G/A cg20703242 chr1:230279135 GALNT2 0.61 8.49 0.42 6.72e-16 Coronary artery disease; LUSC cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg11912956 chr7:73588697 EIF4H 0.39 6.62 0.34 1.46e-10 Triglycerides; LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs45509595 0.841 rs17751184 chr6:27775028 C/T cg26958806 chr6:27640298 NA 0.81 6.28 0.32 1.05e-9 Breast cancer; LUSC cis rs2204008 0.806 rs11525001 chr12:38234397 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.18 0.49 2.23e-21 Bladder cancer; LUSC cis rs11971779 0.680 rs10265718 chr7:139100068 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg07636037 chr3:49044803 WDR6 0.94 12.36 0.56 3.8e-29 Menarche (age at onset); LUSC cis rs35995292 1.000 rs35995292 chr7:38913017 T/G cg19327137 chr7:38886074 VPS41 0.34 5.67 0.3 3.1e-8 Subjective well-being (multi-trait analysis); LUSC cis rs6121246 0.529 rs6060118 chr20:30171209 T/C cg21427119 chr20:30132790 HM13 -0.45 -6.43 -0.33 4.44e-10 Mean corpuscular hemoglobin; LUSC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg23985595 chr17:80112537 CCDC57 0.3 5.69 0.3 2.74e-8 Life satisfaction; LUSC cis rs79349575 0.783 rs4399576 chr17:47009835 G/A cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.7e-12 Type 2 diabetes; LUSC trans rs11098499 0.909 rs28884220 chr4:120307211 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.09 0.32 3.12e-9 Corneal astigmatism; LUSC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg24250549 chr1:154909240 PMVK 0.62 10.1 0.48 4.18e-21 Prostate cancer; LUSC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.27 -0.32 1.1e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6121246 0.559 rs6119650 chr20:30258480 C/A cg13852791 chr20:30311386 BCL2L1 0.94 14.81 0.63 1.69e-38 Mean corpuscular hemoglobin; LUSC cis rs12791968 0.765 rs12790121 chr11:45001089 G/A cg11846598 chr11:44996168 LOC221122 -0.62 -8.85 -0.44 5.18e-17 Inhibitory control; LUSC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg15147215 chr3:52552868 STAB1 -0.29 -5.76 -0.3 1.93e-8 Electroencephalogram traits; LUSC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg11663144 chr21:46675770 NA -0.42 -7.25 -0.37 2.93e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3858145 0.588 rs78041174 chr10:70038771 G/A cg04882175 chr6:131122610 NA -0.64 -8.62 -0.43 2.79e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg06640241 chr16:89574553 SPG7 -0.58 -8.72 -0.43 1.35e-16 Multiple myeloma (IgH translocation); LUSC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg24675658 chr1:53192096 ZYG11B -0.69 -11.9 -0.55 1.91e-27 Monocyte count; LUSC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg17252645 chr8:143867129 LY6D 0.42 8.07 0.4 1.29e-14 Urinary tract infection frequency; LUSC cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7312933 0.618 rs6582390 chr12:42634586 C/T cg01256987 chr12:42539512 GXYLT1 -0.42 -7.93 -0.4 3.28e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10779751 1.000 rs12120734 chr1:11262020 A/G cg08854313 chr1:11322531 MTOR 0.91 16.28 0.67 2.74e-44 Body mass index; LUSC cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.59 0.43 3.45e-16 Menopause (age at onset); LUSC cis rs9457247 0.663 rs1894603 chr6:167434686 C/T cg06454157 chr6:167490870 NA 0.23 5.76 0.3 1.89e-8 Crohn's disease; LUSC cis rs9427116 0.740 rs11264230 chr1:154608418 G/T cg17218026 chr1:154582156 ADAR 0.56 9.92 0.48 1.69e-20 Blood protein levels; LUSC cis rs7424096 0.560 rs7560263 chr2:37183303 G/T cg14987922 chr2:37194071 STRN 0.49 6.59 0.34 1.7e-10 High light scatter reticulocyte percentage of red cells; LUSC trans rs9944715 0.954 rs4542747 chr18:43802169 C/T cg01718231 chr17:29326311 RNF135 -0.5 -6.94 -0.36 2.05e-11 Red cell distribution width;Mean corpuscular volume; LUSC trans rs9329221 0.736 rs2001338 chr8:10251217 A/G cg15556689 chr8:8085844 FLJ10661 0.63 8.85 0.44 5.09e-17 Neuroticism; LUSC cis rs9303401 0.614 rs17175663 chr17:57108437 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.54 0.57 8.27e-30 Cognitive test performance; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg11905131 chr22:24372483 LOC391322 0.39 6.59 0.34 1.73e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 14.35 0.62 1e-36 Platelet count; LUSC cis rs10992471 0.603 rs7033979 chr9:95223980 A/G cg14631576 chr9:95140430 CENPP -0.33 -6.03 -0.31 4.35e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs12540874 0.500 rs12719030 chr7:50485073 T/C cg18232548 chr7:50535776 DDC -0.59 -9.05 -0.44 1.23e-17 Systemic sclerosis; LUSC cis rs11155671 0.530 rs7768665 chr6:150208024 G/A cg04369109 chr6:150039330 LATS1 -0.4 -5.78 -0.3 1.67e-8 Testicular germ cell tumor; LUSC cis rs7177699 0.525 rs7166770 chr15:79113568 A/G cg15571903 chr15:79123663 NA 0.32 5.9 0.31 9.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7829975 0.509 rs2945269 chr8:8115578 G/C cg15556689 chr8:8085844 FLJ10661 0.8 13.53 0.59 1.52e-33 Mood instability; LUSC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg06481639 chr22:41940642 POLR3H -0.5 -5.69 -0.3 2.72e-8 Vitiligo; LUSC cis rs72781680 0.821 rs56064672 chr2:24156769 G/T cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg13390004 chr1:15929781 NA 0.41 6.83 0.35 4.13e-11 Systolic blood pressure; LUSC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg08677398 chr8:58056175 NA 0.42 5.86 0.31 1.11e-8 Developmental language disorder (linguistic errors); LUSC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg00908189 chr16:619842 PIGQ 0.66 10.15 0.49 2.75e-21 Height; LUSC cis rs597539 0.503 rs7131462 chr11:68610143 G/A cg06112835 chr11:68658793 MRPL21 -0.36 -6.06 -0.31 3.76e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12594515 1.000 rs8038320 chr15:45990267 G/C cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC cis rs1950626 0.532 rs61991120 chr14:101455222 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.48 0.38 6.57e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg07636037 chr3:49044803 WDR6 0.93 15.03 0.64 2.28e-39 Parkinson's disease; LUSC cis rs870825 0.616 rs7683537 chr4:185631998 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.33 0.59 8.18e-33 Blood protein levels; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg16799998 chr3:48343164 NME6 0.46 6.05 0.31 3.94e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10170846 0.861 rs6740452 chr2:223518452 C/T cg25565276 chr2:223520875 FARSB 0.64 9.7 0.47 9.46e-20 Schizophrenia (inflammation and infection response interaction); LUSC cis rs3812831 0.662 rs418027 chr13:114929344 A/C cg08824895 chr13:115047677 UPF3A 0.58 8.86 0.44 4.78e-17 Schizophrenia; LUSC cis rs752010 0.684 rs10789402 chr1:42084649 A/G cg06885757 chr1:42089581 HIVEP3 0.48 10.16 0.49 2.53e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg05110241 chr16:68378359 PRMT7 -0.58 -6.72 -0.35 7.89e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg03909863 chr11:638404 DRD4 -0.39 -5.74 -0.3 2.17e-8 Systemic lupus erythematosus; LUSC cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.66e-8 Morning vs. evening chronotype; LUSC cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg24562669 chr7:97807699 LMTK2 -0.36 -6.15 -0.32 2.18e-9 Breast cancer; LUSC trans rs62103177 0.535 rs4799109 chr18:77675188 A/T cg14227996 chr4:17616232 MED28 0.7 7.31 0.37 1.95e-12 Opioid sensitivity; LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg08888203 chr3:10149979 C3orf24 0.59 8.11 0.41 9.88e-15 Alzheimer's disease; LUSC cis rs7267979 1.000 rs11100 chr20:25281184 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10992471 0.756 rs7027595 chr9:95131553 C/T cg14631576 chr9:95140430 CENPP -0.34 -6.02 -0.31 4.5e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06008401 chr16:75657298 ADAT1 -0.41 -6.06 -0.31 3.72e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17828380 1.000 rs34742909 chr15:63529980 C/T cg05507819 chr15:63340323 TPM1 -0.72 -6.21 -0.32 1.54e-9 Social communication problems; LUSC cis rs4363385 0.818 rs1415966 chr1:153002864 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs1007190 0.881 rs75199539 chr17:42930246 A/C cg15406952 chr17:42872593 NA 0.59 5.75 0.3 2.06e-8 DNA methylation (variation); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14305139 chr8:142180543 DENND3 -0.4 -6.0 -0.31 5.11e-9 Mosquito bite size; LUSC cis rs11098499 0.954 rs9993199 chr4:120392873 A/G cg24375607 chr4:120327624 NA -0.76 -11.5 -0.53 5e-26 Corneal astigmatism; LUSC cis rs9300255 0.537 rs1790101 chr12:123704844 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs9283706 0.623 rs1567316 chr5:66312103 T/G cg11590213 chr5:66331682 MAST4 0.43 6.46 0.33 3.66e-10 Coronary artery disease; LUSC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg27539214 chr16:67997921 SLC12A4 -0.58 -7.67 -0.39 1.9e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.75 -0.54 6.51e-27 Mean corpuscular volume; LUSC cis rs734999 0.505 rs10797437 chr1:2539006 T/C cg18932078 chr1:2524107 MMEL1 0.29 6.26 0.32 1.18e-9 Ulcerative colitis; LUSC cis rs2067615 0.524 rs4246257 chr12:107062329 C/T cg15890332 chr12:107067104 RFX4 0.34 6.05 0.31 3.79e-9 Heart rate; LUSC cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs6599077 1.000 rs6809231 chr3:40097789 A/G cg13683864 chr3:40499215 RPL14 -0.6 -7.36 -0.37 1.4e-12 Sleep-related phenotypes; LUSC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg17385448 chr1:15911702 AGMAT 0.35 5.94 0.31 7.27e-9 Systolic blood pressure; LUSC cis rs7937682 0.924 rs10891283 chr11:111527672 A/G cg09085632 chr11:111637200 PPP2R1B -1.1 -17.98 -0.7 4.8e-51 Primary sclerosing cholangitis; LUSC cis rs478304 0.651 rs4930312 chr11:65499719 G/A cg27068330 chr11:65405492 SIPA1 -0.76 -10.88 -0.51 8.57e-24 Acne (severe); LUSC cis rs11190604 1.000 rs2489046 chr10:102346282 A/C cg07080220 chr10:102295463 HIF1AN 0.66 9.42 0.46 7.42e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7568458 0.811 rs3755014 chr2:85764006 C/T cg17127132 chr2:85788382 GGCX 0.46 7.18 0.37 4.44e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.03 -0.31 4.28e-9 Platelet count; LUSC cis rs72781680 0.665 rs2675356 chr2:24074734 C/T cg08917208 chr2:24149416 ATAD2B 0.59 6.81 0.35 4.57e-11 Lymphocyte counts; LUSC cis rs9303280 0.743 rs12946510 chr17:37912377 C/T cg19468946 chr17:37922297 IKZF3 -0.44 -7.0 -0.36 1.38e-11 Self-reported allergy; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg06877462 chr1:205807181 PM20D1 0.49 9.1 0.45 8.47e-18 Menarche (age at onset); LUSC trans rs11098499 0.954 rs13145352 chr4:120409963 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.49 -6.81 -0.35 4.43e-11 Corneal astigmatism; LUSC cis rs9467773 0.935 rs4573 chr6:26546808 A/G cg05738196 chr6:26577821 NA 0.77 13.99 0.61 2.45e-35 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.909 rs11723839 chr4:120299673 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.01 0.4 2e-14 Corneal astigmatism; LUSC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg13939156 chr17:80058883 NA -0.33 -6.43 -0.33 4.45e-10 Life satisfaction; LUSC cis rs4356932 1.000 rs4859584 chr4:76943137 C/G cg00809888 chr4:76862425 NAAA 0.34 5.67 0.3 3.12e-8 Blood protein levels; LUSC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.27 -0.32 1.1e-9 Extrinsic epigenetic age acceleration; LUSC cis rs12410462 0.581 rs7547204 chr1:227560909 C/T cg10327440 chr1:227177885 CDC42BPA -0.63 -5.92 -0.31 8.15e-9 Major depressive disorder; LUSC cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg00071950 chr4:10020882 SLC2A9 0.66 10.97 0.51 3.93e-24 Bone mineral density; LUSC cis rs61931739 0.534 rs11053047 chr12:34161084 C/T cg06521331 chr12:34319734 NA -0.45 -7.38 -0.37 1.29e-12 Morning vs. evening chronotype; LUSC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg23711669 chr6:146136114 FBXO30 -0.92 -17.48 -0.69 4.69e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs2273669 0.504 rs57212784 chr6:109481678 A/G cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1729951 0.575 rs75976 chr3:136700455 G/A cg12473912 chr3:136751656 NA 0.39 6.82 0.35 4.27e-11 Neuroticism; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg22903657 chr4:1355424 KIAA1530 -0.36 -5.97 -0.31 5.93e-9 Obesity-related traits; LUSC cis rs2446066 0.872 rs11170558 chr12:53835035 G/T cg20730629 chr12:53886622 MAP3K12 -0.43 -5.81 -0.3 1.43e-8 Red blood cell count; LUSC cis rs9796 0.870 rs3101436 chr15:41287689 A/G cg18705301 chr15:41695430 NDUFAF1 0.45 7.89 0.4 4.43e-14 Menopause (age at onset); LUSC cis rs1215050 0.791 rs165237 chr4:98712029 T/C cg05340658 chr4:99064831 C4orf37 0.45 7.1 0.36 7.68e-12 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs75804782 0.641 rs11885523 chr2:239344263 G/A cg01134436 chr17:81009848 B3GNTL1 0.63 6.13 0.32 2.54e-9 Morning vs. evening chronotype;Chronotype; LUSC trans rs61931739 0.649 rs708136 chr12:33737411 A/G cg26384229 chr12:38710491 ALG10B 0.42 6.03 0.31 4.23e-9 Morning vs. evening chronotype; LUSC trans rs800082 0.516 rs9852425 chr3:144215405 A/C cg24215973 chr2:240111563 HDAC4 0.45 6.93 0.35 2.24e-11 Smoking behavior; LUSC trans rs72674100 1.000 rs28645642 chr4:97971149 C/T cg09670535 chr1:18959427 PAX7 -0.57 -6.0 -0.31 5.04e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg02353165 chr6:42928485 GNMT 0.68 11.53 0.53 3.94e-26 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.5 0.56 1.14e-29 Motion sickness; LUSC cis rs6964587 0.934 rs73226382 chr7:91692760 T/C cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.54e-8 Breast cancer; LUSC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg10645314 chr2:3704589 ALLC -0.73 -11.69 -0.54 1.05e-26 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg20891283 chr12:69753455 YEATS4 0.93 17.84 0.7 1.8e-50 Cerebrospinal fluid biomarker levels; LUSC trans rs12692738 0.526 rs355875 chr2:165632755 G/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2456568 0.531 rs7105060 chr11:93661268 C/A cg17595323 chr11:93583763 C11orf90 -0.31 -5.67 -0.3 3.09e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg12165864 chr7:66369176 NA -0.53 -7.07 -0.36 9.3e-12 Corneal structure; LUSC cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs2625529 0.652 rs2957740 chr15:72307691 A/G cg16672083 chr15:72433130 SENP8 0.49 8.16 0.41 6.87e-15 Red blood cell count; LUSC cis rs12450688 1 rs12450688 chr17:38144229 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.47 7.63 0.39 2.4e-13 Sum eosinophil basophil counts; LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg25036284 chr2:26402008 FAM59B 0.76 11.07 0.52 1.74e-24 Gut microbiome composition (summer); LUSC cis rs6599077 1.000 rs9848462 chr3:40097204 A/T cg13683864 chr3:40499215 RPL14 0.58 7.57 0.38 3.76e-13 Sleep-related phenotypes; LUSC cis rs11785693 0.862 rs11783719 chr8:4991311 G/T cg26367366 chr8:4980734 NA 0.8 9.4 0.46 8.78e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg07677032 chr17:61819896 STRADA 0.55 8.97 0.44 2.1e-17 Prudent dietary pattern; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg07703079 chr11:430292 ANO9 0.63 6.88 0.35 2.92e-11 Body mass index; LUSC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg11645453 chr3:52864694 ITIH4 0.59 14.12 0.61 8.31e-36 Schizophrenia; LUSC trans rs61931739 0.534 rs4931775 chr12:34050729 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.38 0.42 1.44e-15 Morning vs. evening chronotype; LUSC cis rs12579753 0.917 rs7138533 chr12:82187885 C/G cg07988820 chr12:82153109 PPFIA2 -0.42 -6.07 -0.32 3.48e-9 Resting heart rate; LUSC cis rs9394438 0.628 rs4714078 chr6:37543852 G/A cg00985040 chr6:37553208 NA -0.4 -8.95 -0.44 2.42e-17 IgG glycosylation; LUSC cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.86 8.52 0.42 5.36e-16 Lung cancer in ever smokers; LUSC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg14949292 chr17:78079608 GAA -0.39 -6.51 -0.34 2.69e-10 Yeast infection; LUSC cis rs12579753 0.917 rs11610365 chr12:82218108 C/T cg07988820 chr12:82153109 PPFIA2 -0.44 -6.21 -0.32 1.56e-9 Resting heart rate; LUSC cis rs9929218 0.954 rs12919719 chr16:68822341 C/G cg02972257 chr16:68554789 NA 0.4 5.71 0.3 2.46e-8 Colorectal cancer; LUSC trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg20587970 chr11:113659929 NA -1.32 -18.53 -0.71 3.15e-53 Hip circumference adjusted for BMI; LUSC cis rs8025790 0.508 rs12905371 chr15:67845930 C/T cg05925327 chr15:68127851 NA -0.4 -6.13 -0.32 2.41e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.64 0.54 1.68e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6545883 0.965 rs6734830 chr2:61731112 G/A cg15711740 chr2:61764176 XPO1 -0.47 -7.39 -0.37 1.21e-12 Tuberculosis; LUSC trans rs7939886 0.920 rs59168428 chr11:55956018 G/A cg15704280 chr7:45808275 SEPT13 0.89 6.88 0.35 3e-11 Myopia (pathological); LUSC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg05043794 chr9:111880884 C9orf5 -0.3 -6.58 -0.34 1.84e-10 Menarche (age at onset); LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg26338869 chr17:61819248 STRADA 0.42 6.1 0.32 2.96e-9 Prudent dietary pattern; LUSC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.48 -7.99 -0.4 2.21e-14 Hip circumference adjusted for BMI; LUSC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg16414030 chr3:133502952 NA -0.39 -5.85 -0.3 1.17e-8 Iron status biomarkers; LUSC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.9 -0.4 4.2e-14 Height; LUSC cis rs727505 0.721 rs55890146 chr7:124755461 A/T cg23710748 chr7:124431027 NA -0.4 -7.08 -0.36 8.69e-12 Lewy body disease; LUSC cis rs9788682 0.747 rs11072766 chr15:78771546 C/T cg24631222 chr15:78858424 CHRNA5 0.64 8.51 0.42 5.9e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg18876405 chr7:65276391 NA -0.55 -8.71 -0.43 1.44e-16 Aortic root size; LUSC cis rs807669 0.505 rs28651174 chr22:19236489 C/T cg02655711 chr22:19163373 SLC25A1 0.47 8.41 0.42 1.23e-15 Metabolite levels; LUSC cis rs5758511 0.680 rs5758692 chr22:42669029 T/A cg00645731 chr22:42541494 CYP2D7P1 0.57 10.07 0.48 5.38e-21 Birth weight; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11594513 chr5:134734934 H2AFY 0.46 6.44 0.33 4.22e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg18000306 chr6:288505 NA 0.33 6.33 0.33 7.8e-10 Menopause (age at onset); LUSC cis rs2637266 1.000 rs7073355 chr10:78354419 G/A cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs7937682 0.889 rs2850247 chr11:111637202 C/A cg09085632 chr11:111637200 PPP2R1B 1.21 21.86 0.77 2.17e-66 Primary sclerosing cholangitis; LUSC cis rs9309473 0.607 rs11686504 chr2:73579812 T/C cg20560298 chr2:73613845 ALMS1 -0.55 -8.06 -0.4 1.39e-14 Metabolite levels; LUSC cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20127549 chr11:118868876 CCDC84 -0.4 -5.96 -0.31 6.3e-9 Electrocardiographic conduction measures; LUSC cis rs6456156 0.586 rs2285148 chr6:167490999 G/T cg07741184 chr6:167504864 NA 0.45 7.6 0.38 2.99e-13 Primary biliary cholangitis; LUSC cis rs2109514 1.000 rs6466579 chr7:116151155 T/C cg12739419 chr7:116140593 CAV2 -0.29 -6.36 -0.33 6.46e-10 Prevalent atrial fibrillation; LUSC cis rs2762353 0.935 rs1165215 chr6:25798932 G/A cg03517284 chr6:25882590 NA -0.43 -7.73 -0.39 1.24e-13 Blood metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26708548 chr2:232791101 NPPC -0.42 -6.02 -0.31 4.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6964587 0.967 rs13233496 chr7:91813035 T/C cg22709100 chr7:91322751 NA 0.4 5.86 0.31 1.13e-8 Breast cancer; LUSC cis rs568617 0.953 rs658524 chr11:65647260 A/G cg19792802 chr11:65647270 CTSW -0.41 -6.28 -0.32 1.05e-9 Crohn's disease; LUSC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.04e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.546 rs2098935 chr4:98914376 A/G cg17366294 chr4:99064904 C4orf37 0.52 8.55 0.42 4.5e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg20503657 chr10:835505 NA 0.96 12.98 0.58 1.79e-31 Eosinophil percentage of granulocytes; LUSC cis rs8141797 0.901 rs4306797 chr22:24453375 C/T cg00411358 chr22:24577142 SUSD2 0.58 5.83 0.3 1.32e-8 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs11711311 1.000 rs7622403 chr3:113472434 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.48 -6.71 -0.34 8.55e-11 IgG glycosylation; LUSC cis rs11122272 0.735 rs2486733 chr1:231531465 C/T cg06096015 chr1:231504339 EGLN1 0.58 10.39 0.49 4.2e-22 Hemoglobin concentration; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg08859206 chr1:53392774 SCP2 0.56 9.89 0.48 2.16e-20 Monocyte count; LUSC cis rs10992471 0.603 rs10761160 chr9:95208701 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.77 -0.39 9.49e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg26408565 chr15:76604113 ETFA -0.48 -7.54 -0.38 4.48e-13 Blood metabolite levels; LUSC cis rs1395 0.922 rs11608 chr2:27435374 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.4 -6.57 -0.34 1.99e-10 Blood metabolite levels; LUSC trans rs800082 0.934 rs1007566 chr3:144311752 G/A cg24215973 chr2:240111563 HDAC4 -0.46 -7.04 -0.36 1.08e-11 Smoking behavior; LUSC cis rs2070488 0.775 rs2051214 chr3:38560303 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.68 -11.83 -0.54 3.3699999999999996e-27 Electrocardiographic conduction measures; LUSC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg18240062 chr17:79603768 NPLOC4 0.58 10.12 0.48 3.7e-21 Eye color traits; LUSC cis rs965469 1.000 rs77763497 chr20:3250007 A/G cg25506879 chr20:3388711 C20orf194 -0.55 -6.3 -0.33 9.53e-10 IFN-related cytopenia; LUSC cis rs7084921 0.579 rs11597870 chr10:101847857 T/C cg11888571 chr10:102027403 CWF19L1 -0.47 -6.36 -0.33 6.53e-10 Bone mineral density; LUSC cis rs1215050 0.740 rs2555390 chr4:98999112 A/G cg05340658 chr4:99064831 C4orf37 -0.46 -7.27 -0.37 2.62e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9287719 0.967 rs12464908 chr2:10761496 T/G cg00105475 chr2:10696890 NA 0.35 5.92 0.31 7.8e-9 Prostate cancer; LUSC trans rs4650994 0.544 rs2811311 chr1:178617337 A/G cg05059571 chr16:84539110 KIAA1609 0.47 8.87 0.44 4.44e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg13010199 chr12:38710504 ALG10B 0.65 10.19 0.49 2.11e-21 Bladder cancer; LUSC cis rs1775715 0.737 rs2808078 chr10:32172552 C/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.56 0.34 2.04e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg05165339 chr4:1420672 NA -0.3 -6.93 -0.35 2.15e-11 Longevity; LUSC cis rs2486288 0.656 rs10519018 chr15:45549265 C/T cg14582100 chr15:45693742 SPATA5L1 -0.42 -7.56 -0.38 4.01e-13 Glomerular filtration rate; LUSC cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg06713675 chr4:122721982 EXOSC9 -0.56 -9.68 -0.47 1.09e-19 Type 2 diabetes; LUSC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg11742103 chr11:62369870 EML3;MTA2 0.46 8.03 0.4 1.72e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2200578 0.841 rs112377545 chr2:99774823 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 0.6 6.84 0.35 3.84e-11 IgG glycosylation; LUSC cis rs1949733 0.523 rs62287455 chr4:8544994 A/T cg11789530 chr4:8429930 ACOX3 -0.41 -6.04 -0.31 4.01e-9 Response to antineoplastic agents; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg06145435 chr7:1022769 CYP2W1 0.34 7.39 0.37 1.18e-12 Longevity;Endometriosis; LUSC cis rs2580764 0.566 rs2920878 chr2:55296415 C/T cg09592903 chr2:55203963 RTN4 0.47 9.51 0.46 4.04e-19 Mean platelet volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14094333 chr4:38666051 KLF3;FLJ13197 -0.49 -5.96 -0.31 6.36e-9 Bipolar disorder and schizophrenia; LUSC cis rs644799 0.511 rs10831420 chr11:95478209 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.65 9.75 0.47 6.31e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11190604 1.000 rs4919466 chr10:102241213 T/C cg16342193 chr10:102329863 NA -0.34 -6.13 -0.32 2.41e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs75920871 0.557 rs7123336 chr11:116782819 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.48 -6.06 -0.31 3.78e-9 Subjective well-being; LUSC cis rs5758659 0.623 rs133328 chr22:42408079 T/C cg04733989 chr22:42467013 NAGA 0.4 6.7 0.34 8.93e-11 Cognitive function; LUSC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.75 0.39 1.11e-13 Bipolar disorder; LUSC cis rs7851660 0.874 rs7847010 chr9:100630439 T/C cg13688889 chr9:100608707 NA -0.57 -8.85 -0.44 5.03e-17 Strep throat; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13015042 chr6:170102002 WDR27;C6orf120 -0.44 -6.13 -0.32 2.45e-9 Hepatitis; LUSC cis rs7582180 0.585 rs13031711 chr2:100939433 T/C cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis); LUSC cis rs12908161 0.959 rs1051168 chr15:85200520 G/T cg17507749 chr15:85114479 UBE2QP1 0.59 7.46 0.38 7.38e-13 Schizophrenia; LUSC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg05484376 chr2:27715224 FNDC4 -0.3 -5.65 -0.3 3.46e-8 Total body bone mineral density; LUSC cis rs60871478 1.000 rs9195 chr7:825786 C/T cg05535760 chr7:792225 HEATR2 -0.72 -8.81 -0.43 6.85e-17 Cerebrospinal P-tau181p levels; LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg01802117 chr1:53393560 SCP2 -0.43 -7.19 -0.37 4.19e-12 Monocyte count; LUSC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg24675658 chr1:53192096 ZYG11B -0.58 -9.04 -0.44 1.31e-17 Monocyte count; LUSC cis rs9549367 0.789 rs2287244 chr13:113887173 C/G cg00898013 chr13:113819073 PROZ 0.53 7.96 0.4 2.75e-14 Platelet distribution width; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg12419862 chr22:24373484 LOC391322 -0.88 -14.24 -0.61 2.64e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11098499 0.865 rs11098513 chr4:120316075 A/G cg09307838 chr4:120376055 NA 0.8 11.44 0.53 8.58e-26 Corneal astigmatism; LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs7100689 0.646 rs1953971 chr10:82145647 G/C cg00277334 chr10:82204260 NA -0.51 -7.34 -0.37 1.64e-12 Post bronchodilator FEV1; LUSC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg22875332 chr1:76189707 ACADM 0.72 9.26 0.45 2.47e-18 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs1941687 0.797 rs7228309 chr18:31412519 A/G cg27147174 chr7:100797783 AP1S1 0.45 6.78 0.35 5.47e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg00339695 chr16:24857497 SLC5A11 0.35 5.67 0.3 3.13e-8 Intelligence (multi-trait analysis); LUSC cis rs11630290 0.592 rs12232336 chr15:64153357 T/C cg12036633 chr15:63758958 NA 0.52 6.67 0.34 1.05e-10 Iris characteristics; LUSC cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg04362960 chr10:104952993 NT5C2 0.65 9.37 0.46 1.13e-18 Arsenic metabolism; LUSC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg22166914 chr1:53195759 ZYG11B 0.66 11.28 0.53 3.19e-25 Monocyte count; LUSC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg08742575 chr21:47604166 C21orf56 0.46 6.95 0.36 1.88e-11 Testicular germ cell tumor; LUSC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.76 13.48 0.59 2.34e-33 Total body bone mineral density; LUSC trans rs7824557 0.564 rs2572400 chr8:11234367 T/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.59 -0.38 3.28e-13 Retinal vascular caliber; LUSC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -8.07 -0.4 1.27e-14 Personality dimensions; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11166629 0.637 rs6577657 chr8:135594153 G/C cg27224718 chr8:135614730 ZFAT 0.56 8.08 0.4 1.19e-14 Smoking quantity; LUSC cis rs11674184 0.686 rs2358039 chr2:11729606 A/G cg07314298 chr2:11723111 GREB1 -0.73 -12.33 -0.56 4.75e-29 Endometriosis; LUSC cis rs4648845 0.777 rs2477689 chr1:2395538 G/C cg13556452 chr1:2391241 NA -0.34 -6.13 -0.32 2.41e-9 Schizophrenia; LUSC trans rs1997103 0.954 rs7811098 chr7:55413012 A/G cg20935933 chr6:143382018 AIG1 0.51 7.38 0.37 1.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs1459104 0.571 rs10459012 chr11:55091574 C/A cg03929089 chr4:120376271 NA 0.55 6.15 0.32 2.25e-9 Body mass index; LUSC cis rs2219968 0.828 rs62508223 chr8:78941534 G/C cg00738934 chr8:78996279 NA -0.41 -7.25 -0.37 2.94e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs450533 0.826 rs429941 chr4:107836311 C/T cg19546012 chr19:752860 C19orf21 0.31 6.03 0.31 4.37e-9 Cancer; LUSC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg04518342 chr5:131593106 PDLIM4 0.42 7.57 0.38 3.6e-13 Breast cancer; LUSC trans rs3942852 0.568 rs6485807 chr11:48102867 G/A cg03929089 chr4:120376271 NA -0.58 -7.47 -0.38 6.9e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg24692254 chr21:30365293 RNF160 0.81 13.15 0.58 4.07e-32 Selective IgA deficiency; LUSC cis rs1983170 0.808 rs10874789 chr1:92017990 T/C cg25838465 chr1:92012736 NA 0.41 5.8 0.3 1.57e-8 Eosinophil percentage of white cells; LUSC cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 0.41 6.6 0.34 1.65e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.05 0.31 3.83e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4499344 0.604 rs259245 chr19:33145106 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.7 10.31 0.49 8.26e-22 Mean platelet volume; LUSC cis rs2932538 0.961 rs6537746 chr1:113163529 C/T cg22162597 chr1:113214053 CAPZA1 -0.68 -9.73 -0.47 7.19e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg19729930 chr2:74357872 NA 0.87 15.13 0.64 9.49e-40 Gestational age at birth (maternal effect); LUSC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.966 rs2261795 chr20:25263136 T/C cg03522245 chr20:25566470 NINL 0.35 5.7 0.3 2.58e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1975974 1.000 rs4889703 chr17:21721663 T/C cg18423549 chr17:21743878 NA -0.51 -7.73 -0.39 1.29e-13 Psoriasis; LUSC cis rs3809566 1.000 rs4774471 chr15:63332645 A/T cg05507819 chr15:63340323 TPM1 -0.62 -8.73 -0.43 1.26e-16 Platelet count; LUSC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg15448220 chr1:150897856 SETDB1 0.43 6.38 0.33 5.75e-10 Melanoma; LUSC cis rs117623576 0.941 rs72778716 chr10:32370541 G/A cg03047570 chr10:32398778 NA -0.7 -6.6 -0.34 1.62e-10 Anti-saccade response; LUSC cis rs6500395 0.775 rs4471681 chr16:48665946 C/T cg04672837 chr16:48644449 N4BP1 0.47 7.02 0.36 1.22e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10100465 0.961 rs4876727 chr8:118633834 G/A cg09430518 chr8:118662568 NA -0.28 -5.66 -0.3 3.28e-8 Leprosy; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.93 0.4 3.23e-14 Prudent dietary pattern; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22792432 chr18:18691067 ROCK1 -0.44 -6.42 -0.33 4.64e-10 Electrocardiographic conduction measures; LUSC cis rs981844 0.740 rs12644642 chr4:154686550 G/C cg14289246 chr4:154710475 SFRP2 -0.53 -7.57 -0.38 3.58e-13 Response to statins (LDL cholesterol change); LUSC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.22 0.32 1.5e-9 Schizophrenia; LUSC cis rs870825 0.616 rs7680835 chr4:185652992 C/G cg04058563 chr4:185651563 MLF1IP -0.79 -11.9 -0.55 1.77e-27 Blood protein levels; LUSC cis rs8017423 0.630 rs12589687 chr14:90819570 C/G cg04374321 chr14:90722782 PSMC1 -0.44 -6.57 -0.34 1.89e-10 Mortality in heart failure; LUSC cis rs17014483 0.749 rs3017897 chr4:89646706 C/G cg01026744 chr4:89619053 NAP1L5;HERC3 0.62 5.78 0.3 1.68e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs734999 0.545 rs10910105 chr1:2538209 G/A cg18854424 chr1:2615690 NA 0.51 10.18 0.49 2.18e-21 Ulcerative colitis; LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.45 -0.56 1.77e-29 Alzheimer's disease; LUSC cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg04450456 chr4:17643702 FAM184B -0.39 -6.71 -0.34 8.38e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9341808 0.538 rs12176343 chr6:81027387 G/A cg08355045 chr6:80787529 NA -0.42 -7.15 -0.36 5.41e-12 Sitting height ratio; LUSC cis rs7640424 0.929 rs326358 chr3:107822310 C/T cg09227934 chr3:107805635 CD47 0.46 7.49 0.38 6.14e-13 Body mass index; LUSC cis rs9462027 0.540 rs4282407 chr6:34830162 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.73 -0.3 2.29e-8 Systemic lupus erythematosus; LUSC cis rs7580658 0.963 rs12052483 chr2:128136820 T/G cg09760422 chr2:128146352 NA -0.33 -7.25 -0.37 2.91e-12 Protein C levels; LUSC cis rs950027 0.549 rs11636114 chr15:45601412 C/G cg09092052 chr15:45571596 NA -0.45 -6.18 -0.32 1.86e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs2816062 0.813 rs2816040 chr1:18889536 C/T cg18795169 chr1:18902165 NA 0.97 22.52 0.78 5.93e-69 Urate levels in lean individuals; LUSC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs472402 0.540 rs3776431 chr5:6618756 T/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.4 -5.91 -0.31 8.3e-9 Response to amphetamines; LUSC cis rs977987 0.966 rs62060551 chr16:75502312 A/C cg04384234 chr16:75411784 CFDP1 -0.49 -8.11 -0.41 9.52e-15 Dupuytren's disease; LUSC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg20203395 chr5:56204925 C5orf35 -0.56 -8.06 -0.4 1.39e-14 Coronary artery disease; LUSC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg07952391 chr2:88470173 THNSL2 0.76 6.71 0.34 8.5e-11 Plasma clusterin levels; LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02018176 chr4:1364513 KIAA1530 0.74 13.67 0.6 4.37e-34 Longevity; LUSC cis rs11229555 0.574 rs12292024 chr11:58186716 C/T cg15696309 chr11:58395628 NA -0.64 -7.78 -0.39 9.19e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs12900413 0.687 rs28650972 chr15:90311941 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.82 -0.3 1.37e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs8028313 0.630 rs28565266 chr15:67938011 C/G cg24579218 chr15:68104479 NA -0.37 -6.46 -0.33 3.68e-10 Obesity; LUSC cis rs748404 0.697 rs475261 chr15:43546456 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.94 0.31 7.05e-9 Lung cancer; LUSC cis rs9462027 0.628 rs9469917 chr6:34831369 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.64 -0.3 3.58e-8 Systemic lupus erythematosus; LUSC cis rs501916 0.833 rs59184310 chr15:48050205 A/T cg16110827 chr15:48056943 SEMA6D -0.47 -7.16 -0.36 5.29e-12 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs2408955 0.522 rs973398 chr12:48491048 A/G cg24011408 chr12:48396354 COL2A1 -0.39 -5.69 -0.3 2.82e-8 Glycated hemoglobin levels; LUSC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg11952622 chr19:58962976 ZNF324B 0.61 8.91 0.44 3.43e-17 Mean platelet volume; LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg14092988 chr3:52407081 DNAH1 0.31 5.93 0.31 7.63e-9 Bipolar disorder; LUSC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg22467129 chr15:76604101 ETFA -0.44 -7.05 -0.36 1.06e-11 Blood metabolite levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25654301 chr17:73511699 TSEN54;CASKIN2 -0.37 -6.55 -0.34 2.11e-10 Electrocardiographic conduction measures; LUSC trans rs561341 0.883 rs7406056 chr17:30220224 C/T cg27661571 chr11:113659931 NA -0.56 -6.33 -0.33 8.02e-10 Hip circumference adjusted for BMI; LUSC cis rs2286885 0.896 rs62578061 chr9:129248219 C/T cg15282417 chr9:129245246 FAM125B 0.38 6.36 0.33 6.52e-10 Intraocular pressure; LUSC cis rs1538970 0.924 rs1007858 chr1:45912005 C/T cg05343316 chr1:45956843 TESK2 0.66 9.01 0.44 1.62e-17 Platelet count; LUSC cis rs4141404 0.923 rs2413046 chr22:31665909 C/A cg22777020 chr22:31556080 RNF185 -0.46 -5.8 -0.3 1.55e-8 Paclitaxel-induced neuropathy; LUSC trans rs7939886 0.920 rs76934983 chr11:55993334 A/C cg03929089 chr4:120376271 NA 0.82 6.13 0.32 2.55e-9 Myopia (pathological); LUSC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg13393036 chr8:95962371 TP53INP1 -0.31 -6.14 -0.32 2.39e-9 Type 2 diabetes; LUSC trans rs7618501 0.572 rs4688756 chr3:50040194 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.18 0.45 4.53e-18 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg01503450 chr10:980765 NA -0.37 -5.84 -0.3 1.26e-8 Eosinophil percentage of granulocytes; LUSC cis rs10791097 0.739 rs11222358 chr11:130730497 G/A cg12179176 chr11:130786555 SNX19 0.74 12.0 0.55 7.69e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg05738196 chr6:26577821 NA -0.48 -7.14 -0.36 5.85e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11890956 chr21:40555474 PSMG1 -0.74 -11.5 -0.53 5.13e-26 Menarche (age at onset); LUSC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg16680214 chr1:154839983 KCNN3 -0.53 -10.03 -0.48 7.38e-21 Prostate cancer; LUSC cis rs611744 0.573 rs629996 chr8:109255206 C/T cg21045802 chr8:109455806 TTC35 0.46 7.15 0.36 5.42e-12 Dupuytren's disease; LUSC trans rs7980799 0.716 rs1601008 chr12:33611352 A/G cg13010199 chr12:38710504 ALG10B -0.42 -6.32 -0.33 8.54e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs67072384 0.688 rs66948758 chr11:72440074 A/G cg04827223 chr11:72435913 ARAP1 -0.82 -8.06 -0.4 1.37e-14 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs17270561 0.636 rs1165157 chr6:25792250 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.56 0.34 2.02e-10 Iron status biomarkers; LUSC cis rs4363385 0.747 rs1015995 chr1:152976114 G/C cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 8.88 0.44 4.31e-17 Alzheimer's disease; LUSC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg08564027 chr20:61660810 NA -0.93 -17.4 -0.69 1.01e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg07212818 chr11:638076 DRD4 -0.38 -6.49 -0.33 3.07e-10 Systemic lupus erythematosus; LUSC cis rs17401966 0.522 rs4845930 chr1:10319049 G/A cg17425144 chr1:10567563 PEX14 -0.32 -5.74 -0.3 2.15e-8 Hepatocellular carcinoma; LUSC cis rs6500602 0.739 rs4786502 chr16:4537104 T/C cg08645402 chr16:4508243 NA 0.47 7.87 0.4 5.11e-14 Schizophrenia; LUSC cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg23711669 chr6:146136114 FBXO30 0.81 14.02 0.61 1.86e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs58235267 0.591 rs4671457 chr2:63346356 C/T cg17519650 chr2:63277830 OTX1 0.64 9.52 0.46 3.72e-19 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs1322639 0.614 rs4708414 chr6:169574144 C/G cg04662567 chr6:169592167 NA -0.33 -5.7 -0.3 2.64e-8 Pulse pressure; LUSC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.57 -7.52 -0.38 5.11e-13 Height; LUSC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09844983 chr1:28240714 RPA2 0.45 6.35 0.33 7.13e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.53 -7.19 -0.37 4.21e-12 Renal function-related traits (BUN); LUSC cis rs11577318 0.579 rs35456934 chr1:26686864 G/A cg00852783 chr1:26633632 UBXN11 -0.54 -7.44 -0.38 8.85e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs295137 0.752 rs10931892 chr2:201104997 C/T cg23649088 chr2:200775458 C2orf69 -0.47 -7.2 -0.37 3.92e-12 Asthma (bronchodilator response); LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg24642844 chr7:1081250 C7orf50 -0.81 -10.9 -0.51 7.43e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6543140 0.964 rs2080288 chr2:103022166 G/A cg09003973 chr2:102972529 NA 0.55 7.14 0.36 5.69e-12 Blood protein levels; LUSC cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg05283184 chr6:79620031 NA -0.57 -12.05 -0.55 5.09e-28 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg02475777 chr4:1388615 CRIPAK 0.4 6.11 0.32 2.76e-9 Obesity-related traits; LUSC cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg26384229 chr12:38710491 ALG10B 0.89 15.26 0.64 2.9e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs13315871 1.000 rs13078787 chr3:58430487 C/T cg20936604 chr3:58311152 NA -0.72 -6.77 -0.35 5.83e-11 Cholesterol, total; LUSC cis rs11155671 0.530 rs4869764 chr6:150211828 T/C cg07701084 chr6:150067640 NUP43 0.46 6.93 0.35 2.23e-11 Testicular germ cell tumor; LUSC cis rs2898290 0.622 rs7829381 chr8:11344573 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.66 -0.34 1.13e-10 Systolic blood pressure; LUSC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg03929089 chr4:120376271 NA -0.94 -16.25 -0.66 3.61e-44 Height; LUSC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.69 6.55 0.34 2.23e-10 Cerebrospinal P-tau181p levels; LUSC cis rs7216064 1.000 rs62084240 chr17:65859233 C/A cg12091567 chr17:66097778 LOC651250 -0.75 -9.37 -0.46 1.08e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs8114671 0.562 rs6088635 chr20:33466501 A/G cg07148914 chr20:33460835 GGT7 0.57 8.63 0.43 2.56e-16 Height; LUSC cis rs983392 0.836 rs17602572 chr11:59948374 C/G cg02771260 chr11:59836817 MS4A3 -0.37 -6.09 -0.32 3.02e-9 Alzheimer's disease (late onset); LUSC cis rs10493773 0.775 rs12756013 chr1:86153532 C/T cg17807903 chr1:86174739 ZNHIT6 -0.49 -11.92 -0.55 1.51e-27 Urate levels in overweight individuals; LUSC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg05738196 chr6:26577821 NA -0.48 -7.12 -0.36 6.61e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs2070488 0.775 rs9838614 chr3:38537671 A/C cg24069376 chr3:38537580 EXOG -0.39 -7.6 -0.38 3.01e-13 Electrocardiographic conduction measures; LUSC cis rs117352156 0.628 rs7068466 chr10:29215600 C/T cg06394621 chr10:29236369 NA -0.39 -5.67 -0.3 3.13e-8 Aggressiveness in attention deficit hyperactivity disorder; LUSC trans rs9329221 0.935 rs6601450 chr8:10243101 G/T cg08975724 chr8:8085496 FLJ10661 0.44 6.35 0.33 6.86e-10 Neuroticism; LUSC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg22920501 chr2:26401640 FAM59B -0.73 -10.59 -0.5 8.37e-23 Gut microbiome composition (summer); LUSC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg19622623 chr12:86230825 RASSF9 -0.42 -6.01 -0.31 4.85e-9 Major depressive disorder; LUSC cis rs7267979 0.932 rs6138588 chr20:25487523 C/T cg03522245 chr20:25566470 NINL 0.36 5.89 0.31 9.51e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9341808 0.727 rs9361599 chr6:81025242 C/G cg08355045 chr6:80787529 NA 0.56 9.99 0.48 9.78e-21 Sitting height ratio; LUSC cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg00677455 chr12:58241039 CTDSP2 0.66 9.59 0.46 2.09e-19 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.61 0.47 1.85e-19 Prudent dietary pattern; LUSC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg14298792 chr15:30685198 CHRFAM7A -0.47 -5.77 -0.3 1.78e-8 Huntington's disease progression; LUSC cis rs3806843 0.966 rs3756341 chr5:140171194 C/T cg19875535 chr5:140030758 IK 0.5 8.28 0.41 3.06e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs57920188 0.584 rs12128330 chr1:4092926 G/A cg20703997 chr1:4087676 NA 0.56 8.04 0.4 1.57e-14 Interleukin-17 levels; LUSC cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg15423357 chr2:25149977 NA 0.4 7.86 0.4 5.23e-14 Body mass index; LUSC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.23 -0.32 1.42e-9 Developmental language disorder (linguistic errors); LUSC trans rs17685 0.753 rs7788763 chr7:75651665 T/C cg19862616 chr7:65841803 NCRNA00174 -1.12 -19.31 -0.73 2.46e-56 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4953404 0.613 rs2346877 chr2:46892958 C/G cg09399716 chr2:46890238 NA -0.31 -7.12 -0.36 6.66e-12 Pulse pressure (alcohol consumption interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17470227 chr3:111579551 PHLDB2 0.43 6.41 0.33 4.9e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9479482 1.000 rs9479481 chr6:150357944 A/G cg25797454 chr6:150327115 RAET1K 0.34 7.8 0.39 8.18e-14 Alopecia areata; LUSC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg22920501 chr2:26401640 FAM59B -0.79 -11.76 -0.54 5.97e-27 Gut microbiome composition (summer); LUSC cis rs9914988 0.943 rs34693224 chr17:27079555 C/T cg09479241 chr17:27052676 TLCD1 0.44 5.85 0.3 1.16e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06850241 chr22:41845214 NA 0.31 5.98 0.31 5.69e-9 Vitiligo; LUSC cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg26597838 chr10:835615 NA 1.24 17.01 0.68 3.72e-47 Eosinophil percentage of granulocytes; LUSC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg26597838 chr10:835615 NA 1.01 13.98 0.61 2.84e-35 Eosinophil percentage of granulocytes; LUSC cis rs2625529 0.668 rs34487006 chr15:72462350 G/T cg16672083 chr15:72433130 SENP8 -0.51 -7.38 -0.37 1.26e-12 Red blood cell count; LUSC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg12560992 chr17:57184187 TRIM37 -0.78 -13.67 -0.6 4.15e-34 Intelligence (multi-trait analysis); LUSC cis rs1461503 0.966 rs10892939 chr11:122841959 T/C cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC trans rs1927790 0.697 rs7981931 chr13:96934176 C/T cg03198741 chr6:1003969 LOC285768 -0.4 -6.01 -0.31 4.94e-9 Body mass index; LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg13047869 chr3:10149882 C3orf24 -0.66 -9.86 -0.47 2.63e-20 Alzheimer's disease; LUSC cis rs11031096 0.678 rs12222136 chr11:4180148 T/C cg18678763 chr11:4115507 RRM1 -0.4 -5.67 -0.3 3.07e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11190604 1.000 rs2489039 chr10:102328036 T/A cg07080220 chr10:102295463 HIF1AN 0.69 8.87 0.44 4.46e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg24692254 chr21:30365293 RNF160 0.91 18.43 0.71 7.95e-53 Dental caries; LUSC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11890956 chr21:40555474 PSMG1 -0.74 -11.36 -0.53 1.59e-25 Menarche (age at onset); LUSC cis rs12464559 0.522 rs12472627 chr2:152633114 C/T cg01189475 chr2:152685088 ARL5A 0.62 6.81 0.35 4.62e-11 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg18721089 chr20:30220636 NA -0.37 -6.54 -0.34 2.35e-10 Mean corpuscular hemoglobin; LUSC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg17143192 chr8:8559678 CLDN23 0.66 9.61 0.47 1.84e-19 Obesity-related traits; LUSC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11890956 chr21:40555474 PSMG1 1.03 20.82 0.75 2.6e-62 Cognitive function; LUSC cis rs1372520 0.684 rs2619347 chr4:90745770 G/A cg14346243 chr4:90757452 SNCA -0.39 -5.65 -0.3 3.46e-8 Neuroticism; LUSC cis rs1559088 1.000 rs7245404 chr19:33550589 C/T cg03563238 chr19:33554763 RHPN2 -0.41 -6.47 -0.33 3.59e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7089973 0.604 rs765174 chr10:116601888 C/T cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg01879757 chr17:41196368 BRCA1 -0.54 -8.77 -0.43 9.2e-17 Menopause (age at onset); LUSC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg23625390 chr15:77176239 SCAPER 0.46 6.96 0.36 1.82e-11 Blood metabolite levels; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg03461704 chr1:205818484 PM20D1 0.35 5.75 0.3 2.04e-8 Menarche (age at onset); LUSC cis rs6987853 0.933 rs55881007 chr8:42367290 A/G cg09913449 chr8:42400586 C8orf40 -0.48 -7.95 -0.4 2.82e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg26408565 chr15:76604113 ETFA -0.49 -7.89 -0.4 4.31e-14 Blood metabolite levels; LUSC cis rs9420 0.961 rs11229148 chr11:57621460 A/T cg23127183 chr11:57508653 C11orf31 -0.56 -8.52 -0.42 5.43e-16 Schizophrenia; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Melanoma; LUSC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg11764359 chr7:65958608 NA -0.68 -10.45 -0.5 2.72e-22 Aortic root size; LUSC cis rs11971779 0.680 rs6962366 chr7:139043867 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7824557 0.593 rs11774673 chr8:11191537 T/C cg21775007 chr8:11205619 TDH 0.8 13.51 0.59 1.82e-33 Retinal vascular caliber; LUSC cis rs61931739 0.929 rs10844740 chr12:34067930 C/T cg06521331 chr12:34319734 NA 0.37 6.2 0.32 1.62e-9 Morning vs. evening chronotype; LUSC cis rs2354432 0.607 rs12402309 chr1:146721983 T/A cg25205988 chr1:146714368 CHD1L -1.0 -9.46 -0.46 5.9e-19 Mitochondrial DNA levels; LUSC cis rs9467773 1.000 rs6903973 chr6:26499942 C/A cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.09e-18 Intelligence (multi-trait analysis); LUSC cis rs12908161 1.000 rs12910012 chr15:85298662 T/C cg17173187 chr15:85201210 NMB 0.5 9.39 0.46 9.83e-19 Schizophrenia; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg13560548 chr3:10150139 C3orf24 0.54 7.47 0.38 6.97e-13 Alzheimer's disease; LUSC cis rs7674212 0.570 rs2711898 chr4:104063071 C/T cg16532752 chr4:104119610 CENPE -0.43 -5.9 -0.31 9.13e-9 Type 2 diabetes; LUSC cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg01528321 chr10:82214614 TSPAN14 0.61 8.9 0.44 3.62e-17 Post bronchodilator FEV1; LUSC trans rs853679 0.546 rs200996 chr6:27811828 G/A cg01620082 chr3:125678407 NA -0.7 -7.27 -0.37 2.53e-12 Depression; LUSC cis rs981844 0.712 rs4302444 chr4:154745663 A/G cg14289246 chr4:154710475 SFRP2 -0.44 -6.06 -0.31 3.74e-9 Response to statins (LDL cholesterol change); LUSC cis rs2282802 0.685 rs35214989 chr5:139636127 T/C cg26211634 chr5:139558579 C5orf32 0.44 8.2 0.41 5.25e-15 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08028037 chr13:52027479 INTS6 -0.5 -5.94 -0.31 7.01e-9 Bipolar disorder and schizophrenia; LUSC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg06481639 chr22:41940642 POLR3H -0.49 -6.02 -0.31 4.66e-9 Vitiligo; LUSC cis rs2708377 0.790 rs73051387 chr12:11314463 A/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.84 7.99 0.4 2.15e-14 Bitter taste perception; LUSC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg16339924 chr4:17578868 LAP3 0.59 9.2 0.45 3.85e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg15704280 chr7:45808275 SEPT13 1.03 17.7 0.7 6.21e-50 Coronary artery disease; LUSC cis rs7428496 0.510 rs13089219 chr3:142305956 C/G cg16271453 chr3:142027066 XRN1 -0.48 -8.1 -0.41 1.07e-14 Mean corpuscular hemoglobin; LUSC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6546886 0.912 rs4853009 chr2:74296411 G/A cg14702570 chr2:74259524 NA -0.31 -5.81 -0.3 1.45e-8 Dialysis-related mortality; LUSC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg23029597 chr12:123009494 RSRC2 -0.73 -10.02 -0.48 7.75e-21 Body mass index; LUSC cis rs1018836 0.663 rs56784954 chr8:91505094 C/T cg16814680 chr8:91681699 NA -0.71 -10.89 -0.51 7.52e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1662342 1.000 rs56309710 chr18:3252391 C/A cg00760847 chr18:3262519 MYL12B -0.59 -5.74 -0.3 2.16e-8 QRS duration; LUSC cis rs9527 0.569 rs78193706 chr10:104780564 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.83 0.47 3.35e-20 Arsenic metabolism; LUSC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg16339924 chr4:17578868 LAP3 0.59 9.02 0.44 1.52e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08089702 chr22:21822289 NA 0.46 6.31 0.33 9.04e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg05855489 chr10:104503620 C10orf26 -0.76 -12.89 -0.58 3.89e-31 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs56307353 0.652 rs4807191 chr19:1990309 C/T cg11709110 chr19:1989583 BTBD2 0.33 5.69 0.3 2.78e-8 Coronary artery disease; LUSC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg16060761 chr17:80687452 NA -0.53 -8.0 -0.4 2.1e-14 Glycated hemoglobin levels; LUSC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.74 10.75 0.51 2.33e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs11700980 0.551 rs56852856 chr21:30114177 G/A cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg00033643 chr7:134001901 SLC35B4 0.45 7.11 0.36 7.11e-12 Mean platelet volume; LUSC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg04369109 chr6:150039330 LATS1 -0.56 -8.17 -0.41 6.41e-15 Lung cancer; LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.63 0.65 1.06e-41 Platelet count; LUSC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.28 0.32 1.08e-9 Lung cancer; LUSC cis rs1865721 0.682 rs1561080 chr18:73145847 A/G cg26385618 chr18:73139727 C18orf62 -0.49 -9.32 -0.45 1.65e-18 Intelligence; LUSC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg22437258 chr11:111473054 SIK2 0.53 7.49 0.38 6.36e-13 Primary sclerosing cholangitis; LUSC cis rs2652834 0.851 rs7175185 chr15:63425337 A/G cg05507819 chr15:63340323 TPM1 0.45 5.82 0.3 1.37e-8 HDL cholesterol; LUSC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg16325326 chr1:53192061 ZYG11B 0.94 17.8 0.7 2.46e-50 Monocyte count; LUSC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg20607287 chr7:12443886 VWDE -0.62 -7.49 -0.38 6.29e-13 Coronary artery disease; LUSC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg16524733 chr11:117070046 TAGLN 0.3 5.73 0.3 2.2e-8 Blood protein levels; LUSC cis rs2267137 0.836 rs2283855 chr22:29796775 T/C cg07256473 chr22:29710276 RASL10A 0.37 7.07 0.36 9.28e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs12681287 0.547 rs6998303 chr8:87510185 T/C cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC trans rs4332037 0.624 rs11766944 chr7:1888051 G/A cg11693508 chr17:37793320 STARD3 0.53 6.43 0.33 4.36e-10 Bipolar disorder; LUSC trans rs2262909 0.962 rs409439 chr19:22227432 C/T cg17074339 chr11:11642133 GALNTL4 -0.46 -7.07 -0.36 9.1e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.61 9.1 0.45 8.06e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12579753 0.879 rs7131927 chr12:82166313 T/C cg21231944 chr12:82153410 PPFIA2 -0.38 -6.09 -0.32 3.07e-9 Resting heart rate; LUSC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg11245181 chr6:149772854 ZC3H12D 0.29 6.28 0.33 1.04e-9 Dupuytren's disease; LUSC cis rs637571 0.528 rs11602769 chr11:65594139 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.48 -6.43 -0.33 4.33e-10 Eosinophil percentage of white cells; LUSC cis rs56399783 0.901 rs73033408 chr7:2879755 C/T cg14895029 chr7:2775587 GNA12 0.57 6.41 0.33 4.84e-10 Childhood ear infection; LUSC cis rs6599077 1.000 rs6599078 chr3:40096671 T/G cg13683864 chr3:40499215 RPL14 -0.6 -7.64 -0.39 2.38e-13 Sleep-related phenotypes; LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg00814883 chr7:100076585 TSC22D4 -0.67 -8.8 -0.43 7.24e-17 Platelet count; LUSC cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.51 7.5 0.38 5.86e-13 Personality dimensions; LUSC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg00310523 chr12:86230176 RASSF9 -0.42 -7.52 -0.38 5.04e-13 Major depressive disorder; LUSC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg22920501 chr2:26401640 FAM59B 0.75 10.46 0.5 2.42e-22 Gut microbiome composition (summer); LUSC cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg12935359 chr14:103987150 CKB -0.63 -10.34 -0.49 6.52e-22 Intelligence (multi-trait analysis); LUSC cis rs1559088 0.847 rs2287679 chr19:33600764 T/C cg17764715 chr19:33622953 WDR88 0.6 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg24110177 chr3:50126178 RBM5 -0.55 -9.07 -0.44 1e-17 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.93e-11 Blood metabolite levels; LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg24675658 chr1:53192096 ZYG11B 0.62 9.91 0.48 1.78e-20 Monocyte count; LUSC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.26 0.49 1.23e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs57024841 0.500 rs6560652 chr9:139830940 C/T cg00693599 chr9:139836323 FBXW5 -0.48 -8.07 -0.4 1.28e-14 Beta-trace protein levels; LUSC cis rs920590 0.510 rs4922101 chr8:19648895 A/G cg03894339 chr8:19674705 INTS10 0.8 9.9 0.48 1.92e-20 Acute lymphoblastic leukemia (childhood); LUSC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg05368731 chr17:41323189 NBR1 0.88 13.17 0.58 3.34e-32 Menopause (age at onset); LUSC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.61 0.5 7.35e-23 Monocyte percentage of white cells; LUSC cis rs8060686 0.623 rs2301814 chr16:68105171 C/G cg26727032 chr16:67993705 SLC12A4 -0.41 -6.48 -0.33 3.32e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs9788682 0.747 rs2568490 chr15:78738370 T/C cg06917634 chr15:78832804 PSMA4 0.49 6.05 0.31 3.95e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs2262909 0.924 rs4290587 chr19:22164646 A/G cg05197062 chr11:11642011 GALNTL4 -0.51 -7.0 -0.36 1.39e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg20887711 chr4:1340912 KIAA1530 0.46 7.09 0.36 8.2e-12 Obesity-related traits; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg05768032 chr16:30646687 NA 0.38 5.65 0.3 3.5e-8 Multiple myeloma; LUSC cis rs28602670 1 rs28602670 chr15:78768167 C/G cg18825076 chr15:78729989 IREB2 0.46 6.42 0.33 4.77e-10 Post bronchodilator FEV1; LUSC cis rs2742234 0.666 rs715106 chr10:43616751 C/A cg02780029 chr10:43622663 RET -0.35 -5.9 -0.31 8.98e-9 Hirschsprung disease; LUSC trans rs11165623 0.792 rs13375510 chr1:96920723 A/G cg10631902 chr5:14652156 NA -0.55 -8.99 -0.44 1.9e-17 Hip circumference;Waist circumference; LUSC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg07212818 chr11:638076 DRD4 -0.38 -6.49 -0.33 3.07e-10 Systemic lupus erythematosus; LUSC cis rs9549367 0.713 rs553316 chr13:113838015 A/G cg18105134 chr13:113819100 PROZ 0.66 9.88 0.48 2.32e-20 Platelet distribution width; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg13047869 chr3:10149882 C3orf24 0.63 9.09 0.45 9.2e-18 Alzheimer's disease; LUSC cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg26384229 chr12:38710491 ALG10B 0.87 14.46 0.62 3.85e-37 Drug-induced liver injury (flucloxacillin); LUSC trans rs9329221 0.736 rs2001337 chr8:10251154 G/A cg15556689 chr8:8085844 FLJ10661 0.65 9.15 0.45 5.69e-18 Neuroticism; LUSC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg02753203 chr1:228287806 NA 0.69 12.31 0.56 5.48e-29 Diastolic blood pressure; LUSC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg25319279 chr11:5960081 NA -0.43 -6.69 -0.34 9.44e-11 DNA methylation (variation); LUSC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg22920501 chr2:26401640 FAM59B -0.73 -10.38 -0.49 4.71e-22 Gut microbiome composition (summer); LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.48e-9 Menopause (age at onset); LUSC cis rs11190604 1.000 rs11190607 chr10:102303614 C/T cg16342193 chr10:102329863 NA -0.35 -6.22 -0.32 1.53e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg11742103 chr11:62369870 EML3;MTA2 0.55 8.95 0.44 2.53e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs477692 1.000 rs580745 chr10:131414401 G/A cg05714579 chr10:131428358 MGMT 0.51 7.66 0.39 2e-13 Response to temozolomide; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg16817946 chr17:40950804 CNTD1;CCDC56 0.36 6.26 0.32 1.16e-9 Educational attainment (years of education); LUSC cis rs9486715 0.867 rs4131519 chr6:96964939 G/A cg06623918 chr6:96969491 KIAA0776 0.92 16.46 0.67 5.46e-45 Headache; LUSC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg12379764 chr21:47803548 PCNT -0.45 -6.17 -0.32 2.01e-9 Testicular germ cell tumor; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg06873352 chr17:61820015 STRADA 0.72 12.92 0.58 2.97e-31 Prudent dietary pattern; LUSC cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg08564027 chr20:61660810 NA 0.91 17.46 0.69 5.62e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC cis rs11792861 0.591 rs4978763 chr9:111728067 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.67 12.25 0.56 9.75e-29 Menarche (age at onset); LUSC cis rs2204008 0.558 rs66545149 chr12:38204694 A/G cg26384229 chr12:38710491 ALG10B 0.93 15.61 0.65 1.21e-41 Bladder cancer; LUSC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg15110403 chr19:17392923 ANKLE1 -0.59 -7.94 -0.4 3.09e-14 Systemic lupus erythematosus; LUSC cis rs868036 0.718 rs28399056 chr15:68116010 C/A cg05925327 chr15:68127851 NA -0.38 -6.04 -0.31 4.22e-9 Restless legs syndrome; LUSC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg11645453 chr3:52864694 ITIH4 0.32 7.55 0.38 4.18e-13 Bipolar disorder; LUSC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg26441486 chr22:50317300 CRELD2 -0.54 -8.21 -0.41 4.86e-15 Schizophrenia; LUSC cis rs72781680 0.821 rs1022346 chr2:24127849 T/C cg08917208 chr2:24149416 ATAD2B 0.59 6.83 0.35 3.96e-11 Lymphocyte counts; LUSC cis rs7089973 0.872 rs11818114 chr10:116634878 G/C cg23260525 chr10:116636907 FAM160B1 0.39 7.99 0.4 2.19e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12980942 0.872 rs11879562 chr19:41804976 C/G cg25627403 chr19:41769009 HNRNPUL1 0.56 6.26 0.32 1.21e-9 Coronary artery disease; LUSC cis rs73200209 0.744 rs11610671 chr12:116411562 C/T cg01776926 chr12:116560359 MED13L -0.52 -5.82 -0.3 1.38e-8 Total body bone mineral density; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg27535305 chr1:53392650 SCP2 0.39 7.32 0.37 1.91e-12 Monocyte count; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg07362569 chr17:61921086 SMARCD2 -0.39 -7.82 -0.39 7e-14 Prudent dietary pattern; LUSC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg09323728 chr8:95962352 TP53INP1 -0.39 -7.77 -0.39 1e-13 Type 2 diabetes; LUSC cis rs9457247 0.765 rs3752520 chr6:167436159 T/C cg06454157 chr6:167490870 NA -0.25 -6.12 -0.32 2.67e-9 Crohn's disease; LUSC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.39 -5.66 -0.3 3.21e-8 Tonsillectomy; LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs7824557 0.872 rs1347410 chr8:11111242 G/A cg27411982 chr8:10470053 RP1L1 -0.38 -6.17 -0.32 1.97e-9 Retinal vascular caliber; LUSC cis rs654950 0.875 rs2810550 chr1:41995339 T/C cg06885757 chr1:42089581 HIVEP3 -0.34 -6.54 -0.34 2.34e-10 Airway imaging phenotypes; LUSC trans rs747782 0.527 rs12289516 chr11:48234680 G/A cg15704280 chr7:45808275 SEPT13 0.69 6.48 0.33 3.28e-10 Intraocular pressure; LUSC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg11766577 chr21:47581405 C21orf56 -0.5 -7.56 -0.38 3.88e-13 Testicular germ cell tumor; LUSC cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg00677455 chr12:58241039 CTDSP2 0.56 7.95 0.4 2.88e-14 Intelligence (multi-trait analysis); LUSC cis rs17092148 0.943 rs4911160 chr20:33349940 G/A cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg06627628 chr2:24431161 ITSN2 -0.61 -7.32 -0.37 1.88e-12 Lymphocyte counts; LUSC cis rs4474465 0.850 rs4597089 chr11:78262244 A/G cg27205649 chr11:78285834 NARS2 0.51 6.14 0.32 2.29e-9 Alzheimer's disease (survival time); LUSC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.57 -8.4 -0.42 1.3e-15 Menarche (age at onset); LUSC cis rs8060686 0.516 rs4567701 chr16:68163662 T/C cg05110241 chr16:68378359 PRMT7 -0.5 -6.35 -0.33 7.05e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs765787 0.505 rs1648302 chr15:45494238 A/G cg25801113 chr15:45476975 SHF 0.33 6.72 0.35 7.78e-11 Uric acid levels; LUSC cis rs7927592 0.913 rs10896346 chr11:68352671 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.77 -0.3 1.85e-8 Total body bone mineral density; LUSC cis rs4285028 0.898 rs4305455 chr3:121619774 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.76 -10.29 -0.49 9.28e-22 Multiple sclerosis; LUSC cis rs12618769 0.597 rs72821930 chr2:99127525 C/T cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00590991 chr5:176900010 DBN1 0.75 6.08 0.32 3.35e-9 Cognitive performance; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12832228 chr8:28244096 ZNF395 0.4 6.2 0.32 1.69e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6424115 1.000 rs12116511 chr1:24162662 A/G cg15997130 chr1:24165203 NA -0.54 -8.72 -0.43 1.3e-16 Immature fraction of reticulocytes; LUSC cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg06784218 chr1:46089804 CCDC17 -0.53 -11.02 -0.52 2.64e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg00431813 chr7:1051703 C7orf50 -0.47 -7.98 -0.4 2.35e-14 Longevity;Endometriosis; LUSC cis rs231513 0.911 rs231511 chr17:41966335 T/C cg26893861 chr17:41843967 DUSP3 -0.54 -6.02 -0.31 4.52e-9 Cognitive function; LUSC trans rs7819412 0.623 rs7833435 chr8:10801137 A/G cg15556689 chr8:8085844 FLJ10661 -0.52 -7.55 -0.38 4.15e-13 Triglycerides; LUSC cis rs1904096 0.506 rs13435702 chr4:95167751 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.44 -0.42 9.59e-16 Type 2 diabetes; LUSC cis rs2637266 0.934 rs2395408 chr10:78380929 G/A cg18941641 chr10:78392320 NA 0.38 6.94 0.35 2.08e-11 Pulmonary function; LUSC cis rs75229567 0.618 rs10219700 chr12:70201730 A/G cg10114359 chr12:70132523 RAB3IP -0.91 -8.96 -0.44 2.36e-17 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg05896524 chr21:47604654 C21orf56 -0.45 -6.51 -0.34 2.77e-10 Testicular germ cell tumor; LUSC cis rs11018874 0.597 rs10765243 chr11:89855118 C/G cg14505434 chr11:89522851 NA 0.39 5.98 0.31 5.77e-9 White blood cell types; LUSC cis rs9300255 0.722 rs12322888 chr12:123825559 A/G cg00376283 chr12:123451042 ABCB9 0.65 7.67 0.39 1.91e-13 Neutrophil percentage of white cells; LUSC cis rs4443100 0.670 rs3788338 chr22:23412058 G/A cg14186256 chr22:23484241 RTDR1 0.55 7.03 0.36 1.17e-11 Serum parathyroid hormone levels; LUSC cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg18876405 chr7:65276391 NA 0.57 9.25 0.45 2.85e-18 Aortic root size; LUSC cis rs8092503 1.000 rs1965662 chr18:52486080 C/T cg12377874 chr18:52495404 RAB27B 0.35 6.25 0.32 1.27e-9 Childhood body mass index; LUSC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg25767906 chr1:53392781 SCP2 -0.36 -6.1 -0.32 2.89e-9 Monocyte count; LUSC cis rs9329221 0.648 rs4512422 chr8:10258889 C/T cg21775007 chr8:11205619 TDH -0.53 -7.43 -0.38 9.07e-13 Neuroticism; LUSC cis rs9837602 0.872 rs1489816 chr3:99769088 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.19 -0.32 1.79e-9 Breast cancer; LUSC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg11752832 chr7:134001865 SLC35B4 0.57 8.85 0.44 5.24e-17 Mean platelet volume; LUSC cis rs73001065 0.591 rs57962361 chr19:19425025 C/T cg03709012 chr19:19516395 GATAD2A 0.88 7.97 0.4 2.45e-14 LDL cholesterol; LUSC cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.62 9.7 0.47 9e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2985684 0.802 rs8015368 chr14:50020510 G/A cg04989706 chr14:50066350 PPIL5 -0.47 -6.39 -0.33 5.61e-10 Carotid intima media thickness; LUSC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg23093090 chr10:104574429 C10orf26 -0.45 -8.24 -0.41 3.99e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg11752832 chr7:134001865 SLC35B4 0.56 8.77 0.43 9.6e-17 Mean platelet volume; LUSC cis rs1023500 0.596 rs133350 chr22:42429049 A/G cg04733989 chr22:42467013 NAGA 0.63 9.91 0.48 1.8899999999999998e-20 Schizophrenia; LUSC trans rs7824557 0.933 rs6601576 chr8:11100275 A/T cg06636001 chr8:8085503 FLJ10661 -0.52 -8.16 -0.41 7.01e-15 Retinal vascular caliber; LUSC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg21644426 chr2:191273491 MFSD6 0.59 9.4 0.46 9.08e-19 Pulse pressure; LUSC cis rs425277 1.000 rs427811 chr1:2075560 T/G cg03732007 chr1:2071316 PRKCZ 0.47 7.61 0.38 2.91e-13 Height; LUSC trans rs72674100 1.000 rs9993686 chr4:97974447 C/T cg16405019 chr1:18959625 PAX7 -0.55 -6.47 -0.33 3.4e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs9309473 0.607 rs7560272 chr2:73561485 A/T cg20560298 chr2:73613845 ALMS1 -0.53 -8.02 -0.4 1.76e-14 Metabolite levels; LUSC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg04317338 chr11:64019027 PLCB3 0.71 8.07 0.4 1.25e-14 Mean platelet volume; LUSC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg13902645 chr11:5959945 NA -0.56 -7.87 -0.4 5.12e-14 DNA methylation (variation); LUSC trans rs11165623 0.792 rs6593599 chr1:96911468 C/T cg10631902 chr5:14652156 NA -0.55 -8.87 -0.44 4.43e-17 Hip circumference;Waist circumference; LUSC cis rs4423214 1.000 rs12808368 chr11:71170817 C/T cg05163923 chr11:71159392 DHCR7 0.76 11.31 0.53 2.55e-25 Vitamin D levels; LUSC cis rs4664308 0.967 rs62175559 chr2:160955833 G/A cg03641300 chr2:160917029 PLA2R1 -0.68 -11.63 -0.54 1.74e-26 Idiopathic membranous nephropathy; LUSC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.45 0.67 5.85e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs7312933 0.558 rs1669886 chr12:42838240 A/G cg01256987 chr12:42539512 GXYLT1 0.36 6.59 0.34 1.71e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6772849 0.930 rs68090762 chr3:128343907 C/T cg16766828 chr3:128327626 NA -0.31 -5.68 -0.3 2.93e-8 Monocyte percentage of white cells;Monocyte count; LUSC cis rs1997103 1.000 rs9649857 chr7:55411777 C/T cg17469321 chr7:55412551 NA 0.64 10.19 0.49 2.02e-21 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1371867 0.875 rs962451 chr8:101331010 C/T cg00191853 chr8:101177733 SPAG1 -0.41 -6.69 -0.34 9.6e-11 Atrioventricular conduction; LUSC cis rs4891159 0.790 rs77878087 chr18:74116337 G/A cg24786174 chr18:74118243 ZNF516 -0.83 -15.23 -0.64 3.98e-40 Longevity; LUSC cis rs1448094 0.967 rs7312144 chr12:86328256 T/C cg02569458 chr12:86230093 RASSF9 0.42 6.86 0.35 3.31e-11 Major depressive disorder; LUSC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg03676636 chr4:99064102 C4orf37 0.32 6.9 0.35 2.61e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs9430161 0.579 rs7542158 chr1:11040193 G/A cg02454025 chr1:11042201 C1orf127 0.91 16.95 0.68 6.13e-47 Ewing sarcoma; LUSC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.82 12.4 0.56 2.57e-29 Cognitive test performance; LUSC cis rs7572644 0.699 rs10177845 chr2:28124171 G/A cg27432699 chr2:27873401 GPN1 -0.52 -6.96 -0.36 1.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.66e-10 Lung cancer; LUSC cis rs8040855 0.599 rs6496800 chr15:85728286 G/C cg04831495 chr15:85060580 GOLGA6L5 0.41 6.89 0.35 2.73e-11 Bulimia nervosa; LUSC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg11764359 chr7:65958608 NA -0.68 -10.54 -0.5 1.28e-22 Aortic root size; LUSC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg16386425 chr10:429943 DIP2C -0.45 -7.06 -0.36 9.68e-12 Psychosis in Alzheimer's disease; LUSC cis rs12310956 0.515 rs1830086 chr12:33958874 C/T cg06521331 chr12:34319734 NA -0.46 -7.27 -0.37 2.65e-12 Morning vs. evening chronotype; LUSC cis rs478304 0.903 rs61895677 chr11:65549415 T/C cg08755490 chr11:65554678 OVOL1 0.42 6.02 0.31 4.69e-9 Acne (severe); LUSC cis rs9788682 0.747 rs28480606 chr15:78762313 A/G cg24631222 chr15:78858424 CHRNA5 0.64 8.51 0.42 5.9e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs765787 0.530 rs1631533 chr15:45518628 C/T cg24006582 chr15:45444508 DUOX1 -0.62 -9.12 -0.45 7.21e-18 Uric acid levels; LUSC cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg18196295 chr10:418757 DIP2C -0.44 -6.73 -0.35 7.54e-11 Psychosis in Alzheimer's disease; LUSC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg19346786 chr7:2764209 NA -0.42 -7.27 -0.37 2.49e-12 Height; LUSC trans rs11098499 0.954 rs2389802 chr4:120325732 C/A cg25214090 chr10:38739885 LOC399744 0.56 8.2 0.41 5.17e-15 Corneal astigmatism; LUSC cis rs472402 0.580 rs11134173 chr5:6659696 C/A cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.53 -7.42 -0.38 9.69e-13 Response to amphetamines; LUSC cis rs2857891 0.695 rs2857896 chr11:6982825 A/T cg04053776 chr11:6947353 ZNF215 0.41 6.05 0.31 3.98e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs7582180 0.677 rs2067783 chr2:100877370 T/C cg08017756 chr2:100939284 LONRF2 -0.36 -6.21 -0.32 1.53e-9 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg03806693 chr22:41940476 POLR3H 1.0 14.25 0.62 2.41e-36 Vitiligo; LUSC trans rs11098499 0.618 rs28491261 chr4:120294900 C/A cg25214090 chr10:38739885 LOC399744 0.55 7.99 0.4 2.16e-14 Corneal astigmatism; LUSC cis rs1953600 1.000 rs2573346 chr10:81918041 G/A cg04850286 chr10:81895943 PLAC9 -0.33 -5.74 -0.3 2.08e-8 Sarcoidosis; LUSC cis rs17014483 0.749 rs2924934 chr4:89628242 G/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.71 6.47 0.33 3.5e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17156255 chr2:27632527 PPM1G -0.41 -6.05 -0.31 3.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg03526776 chr6:41159608 TREML2 0.5 9.76 0.47 5.72e-20 Alzheimer's disease (late onset); LUSC trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg15704280 chr7:45808275 SEPT13 -0.46 -6.37 -0.33 6.38e-10 Height; LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.16 -0.32 2.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7106204 0.514 rs7935857 chr11:24252420 C/T ch.11.24196551F chr11:24239977 NA 0.92 10.2 0.49 1.98e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2303282 0.639 rs4462584 chr16:56443850 T/C cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.88e-12 Breast cancer; LUSC cis rs983392 0.709 rs4939320 chr11:59981801 T/C cg20284999 chr11:59952153 MS4A6A -0.36 -6.08 -0.32 3.24e-9 Alzheimer's disease (late onset); LUSC trans rs4942242 0.967 rs58325557 chr13:44217771 A/G cg19169023 chr15:41853346 TYRO3 0.46 7.42 0.38 9.88e-13 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs61931739 0.500 rs12809868 chr12:34464905 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.73 0.65 4.14e-42 Morning vs. evening chronotype; LUSC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg22467129 chr15:76604101 ETFA -0.44 -7.03 -0.36 1.17e-11 Blood metabolite levels; LUSC cis rs7666738 0.606 rs3846446 chr4:99099768 C/A cg03676636 chr4:99064102 C4orf37 0.28 5.91 0.31 8.64e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg10978503 chr1:24200527 CNR2 0.48 11.24 0.52 4.32e-25 Immature fraction of reticulocytes; LUSC cis rs66887589 0.807 rs9799664 chr4:120326678 C/T cg24375607 chr4:120327624 NA 0.49 7.49 0.38 6.14e-13 Diastolic blood pressure; LUSC cis rs7640424 0.589 rs7612356 chr3:107811037 C/G cg09227934 chr3:107805635 CD47 -0.54 -7.65 -0.39 2.12e-13 Body mass index; LUSC cis rs4132509 0.649 rs12140040 chr1:243871922 G/A cg21452805 chr1:244014465 NA 0.61 5.95 0.31 6.71e-9 RR interval (heart rate); LUSC trans rs62238980 0.614 rs117586262 chr22:32406424 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs4478858 0.775 rs59865338 chr1:31706643 A/G cg00250761 chr1:31883323 NA -0.36 -9.42 -0.46 7.74e-19 Alcohol dependence; LUSC cis rs4595586 0.545 rs7970307 chr12:39380760 A/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs7647973 1.000 rs10155014 chr3:49432321 C/T cg07636037 chr3:49044803 WDR6 0.71 9.64 0.47 1.48e-19 Menarche (age at onset); LUSC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 6.97e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10845606 1.000 rs10845606 chr12:12834894 G/T cg09462578 chr12:12878428 APOLD1 -0.53 -6.61 -0.34 1.5e-10 Systemic lupus erythematosus; LUSC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg03351412 chr1:154909251 PMVK 0.56 8.9 0.44 3.73e-17 Prostate cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg20645649 chr9:127624485 RPL35 0.45 6.17 0.32 1.95e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4930103 0.935 rs2075745 chr11:2018336 A/T cg06197492 chr11:2016605 H19 0.42 6.87 0.35 3.23e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs8099014 0.954 rs7230036 chr18:56098397 C/T cg12907477 chr18:56117327 MIR122 0.43 6.88 0.35 2.98e-11 Platelet count; LUSC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg07837209 chr13:79184101 NA -0.5 -7.1 -0.36 7.7e-12 Large artery stroke; LUSC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg20135002 chr11:47629003 NA -0.51 -7.78 -0.39 9.07e-14 Subjective well-being; LUSC trans rs57046232 0.552 rs1305008 chr20:6324198 T/G cg17788362 chr6:86352627 SYNCRIP 0.44 6.15 0.32 2.15e-9 Colorectal cancer; LUSC cis rs6456156 0.711 rs1855025 chr6:167537594 A/G cg07741184 chr6:167504864 NA -0.34 -6.1 -0.32 2.94e-9 Primary biliary cholangitis; LUSC cis rs4343996 0.754 rs1525557 chr7:3351405 A/C cg21248987 chr7:3385318 SDK1 -0.36 -6.24 -0.32 1.33e-9 Motion sickness; LUSC cis rs7903847 0.642 rs11189180 chr10:99143529 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.07 -0.4 1.26e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg24531977 chr5:56204891 C5orf35 1.04 15.58 0.65 1.65e-41 Initial pursuit acceleration; LUSC cis rs3772130 0.583 rs6767409 chr3:121564989 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.83 13.54 0.6 1.29e-33 Cognitive performance; LUSC cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg24130564 chr14:104152367 KLC1 0.46 6.59 0.34 1.7e-10 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg02475777 chr4:1388615 CRIPAK 0.44 6.51 0.34 2.7e-10 Obesity-related traits; LUSC cis rs4494114 1.000 rs9439081 chr1:39343012 A/G cg25970120 chr1:39325951 RRAGC -0.41 -6.46 -0.33 3.78e-10 Blood protein levels; LUSC cis rs17154702 0.506 rs2427 chr8:8641125 A/G cg01851573 chr8:8652454 MFHAS1 -0.6 -7.28 -0.37 2.33e-12 Neurocognitive impairment in HIV-1 infection (continuous); LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg01171360 chr6:293285 DUSP22 -0.49 -7.05 -0.36 1.02e-11 Menopause (age at onset); LUSC cis rs950027 0.620 rs1617634 chr15:45615578 A/G cg14582100 chr15:45693742 SPATA5L1 0.48 8.91 0.44 3.37e-17 Response to fenofibrate (adiponectin levels); LUSC cis rs79911532 0.515 rs116006876 chr7:75775918 G/C cg03592824 chr7:75666768 STYXL1 0.65 6.2 0.32 1.7e-9 Mononucleosis; LUSC cis rs6500602 0.727 rs3761681 chr16:4566857 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 7.35 0.37 1.52e-12 Schizophrenia; LUSC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg20243544 chr17:37824526 PNMT 0.45 6.3 0.33 9.6e-10 Asthma; LUSC cis rs6987853 0.787 rs2923441 chr8:42429937 G/T cg09913449 chr8:42400586 C8orf40 -0.51 -9.04 -0.44 1.28e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg11102782 chr19:18549136 ISYNA1 -0.34 -6.36 -0.33 6.54e-10 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22917801 chr14:24665198 TM9SF1 -0.4 -6.02 -0.31 4.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2635047 0.967 rs12960378 chr18:44614090 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 7.41 0.38 1.03e-12 Educational attainment; LUSC cis rs2197308 0.565 rs12809769 chr12:37909968 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs8058578 0.832 rs35969813 chr16:30714417 T/C cg02466173 chr16:30829666 NA -0.59 -10.72 -0.51 2.97e-23 Multiple myeloma; LUSC cis rs3105593 0.521 rs3098205 chr15:50742977 G/T cg08437265 chr15:50716283 USP8 0.39 5.74 0.3 2.09e-8 QT interval; LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg16680214 chr1:154839983 KCNN3 -0.51 -9.67 -0.47 1.18e-19 Prostate cancer; LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg13397359 chr6:42928475 GNMT 0.57 9.39 0.46 9.63e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs62400317 0.859 rs10948204 chr6:45124300 T/C cg18551225 chr6:44695536 NA -0.42 -6.8 -0.35 4.79e-11 Total body bone mineral density; LUSC cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -8.17 -0.41 6.4e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg22709100 chr7:91322751 NA 0.4 5.86 0.31 1.09e-8 Breast cancer; LUSC trans rs561341 0.882 rs16967101 chr17:30377162 A/G cg20587970 chr11:113659929 NA -1.19 -16.23 -0.66 4.39e-44 Hip circumference adjusted for BMI; LUSC cis rs10911232 0.507 rs10797816 chr1:182998486 A/T ch.1.3577855R chr1:183094577 LAMC1 0.71 11.03 0.52 2.45e-24 Hypertriglyceridemia; LUSC cis rs2840044 1.000 rs225304 chr17:33921857 G/T cg05299278 chr17:33885742 SLFN14 0.3 6.28 0.32 1.05e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg07828024 chr6:149772892 ZC3H12D -0.33 -7.27 -0.37 2.58e-12 Dupuytren's disease; LUSC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg06634786 chr22:41940651 POLR3H 0.53 6.3 0.33 9.15e-10 Vitiligo; LUSC cis rs738322 0.967 rs132971 chr22:38561911 T/G cg25457927 chr22:38595422 NA -0.39 -8.07 -0.4 1.25e-14 Cutaneous nevi; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg13453750 chr1:205783389 SLC41A1 -0.31 -6.03 -0.31 4.41e-9 Menarche (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03795608 chr3:127872288 EEFSEC 0.81 6.28 0.32 1.07e-9 Cognitive performance; LUSC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg00784671 chr22:46762841 CELSR1 -0.47 -6.31 -0.33 8.66e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1729951 0.575 rs1682333 chr3:136688618 G/A cg21827317 chr3:136751795 NA 0.39 6.93 0.35 2.22e-11 Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21586955 chr2:220042941 FAM134A;C2orf24 -0.43 -6.19 -0.32 1.76e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6430585 0.536 rs3213892 chr2:136552517 G/A cg07169764 chr2:136633963 MCM6 1.18 17.58 0.69 2e-49 Corneal structure; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.59 0.38 3.32e-13 Bipolar disorder; LUSC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs8017423 0.935 rs8012299 chr14:90715822 G/T cg04374321 chr14:90722782 PSMC1 0.76 12.12 0.55 2.88e-28 Mortality in heart failure; LUSC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg24250549 chr1:154909240 PMVK -0.62 -9.7 -0.47 9.19e-20 Prostate cancer; LUSC cis rs9463078 0.764 rs494982 chr6:44937255 C/T cg25276700 chr6:44698697 NA -0.29 -6.06 -0.31 3.76e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs6840360 0.533 rs4696295 chr4:152717430 T/C cg22705602 chr4:152727874 NA 0.38 7.97 0.4 2.5e-14 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg04450456 chr4:17643702 FAM184B 0.4 6.57 0.34 1.91e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9467773 1.000 rs6925895 chr6:26572165 G/T cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.7e-36 Intelligence (multi-trait analysis); LUSC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg20243544 chr17:37824526 PNMT 0.49 6.95 0.36 1.91e-11 Asthma; LUSC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg09021430 chr5:549028 NA -0.53 -6.97 -0.36 1.7e-11 Lung disease severity in cystic fibrosis; LUSC cis rs34779708 0.643 rs4275563 chr10:35545286 G/A cg03585969 chr10:35415529 CREM 0.54 7.59 0.38 3.28e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg00677455 chr12:58241039 CTDSP2 0.61 8.57 0.42 3.9e-16 Multiple sclerosis; LUSC cis rs16866061 1.000 rs10498163 chr2:225434445 A/G cg12698349 chr2:225449008 CUL3 0.87 14.27 0.62 2.17e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg18721089 chr20:30220636 NA -0.37 -6.54 -0.34 2.35e-10 Mean corpuscular hemoglobin; LUSC cis rs7267979 1.000 rs6050555 chr20:25328543 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -19.5 -0.73 4.38e-57 Liver enzyme levels (alkaline phosphatase); LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg07167872 chr1:205819463 PM20D1 0.87 16.79 0.68 2.62e-46 Menarche (age at onset); LUSC trans rs1941687 0.735 rs8085989 chr18:31415929 G/A cg27147174 chr7:100797783 AP1S1 -0.46 -6.88 -0.35 2.97e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg00149659 chr3:10157352 C3orf10 0.89 12.11 0.55 3.04e-28 Alzheimer's disease; LUSC cis rs5769707 0.632 rs5770601 chr22:50021903 A/G cg10356904 chr22:49881777 NA -0.29 -5.78 -0.3 1.7e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2996428 0.561 rs72640913 chr1:3747023 C/G cg13057898 chr1:3703894 LRRC47 0.48 7.9 0.4 3.95e-14 Red cell distribution width; LUSC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg11344533 chr11:111475393 SIK2 -0.48 -6.78 -0.35 5.35e-11 Primary sclerosing cholangitis; LUSC cis rs614226 0.935 rs7137953 chr12:120894685 C/T cg27489772 chr12:121021490 NA -0.59 -7.63 -0.39 2.45e-13 Type 1 diabetes nephropathy; LUSC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg07701084 chr6:150067640 NUP43 0.54 8.09 0.4 1.14e-14 Lung cancer; LUSC cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg06784218 chr1:46089804 CCDC17 -0.51 -9.59 -0.46 2.15e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs61990749 0.597 rs8016416 chr14:78213100 T/A cg02301378 chr14:78227641 SNW1;C14orf178 0.62 6.59 0.34 1.76e-10 Fibroblast growth factor basic levels; LUSC cis rs6500395 0.735 rs7204345 chr16:48666726 T/C cg04672837 chr16:48644449 N4BP1 0.46 6.8 0.35 4.8e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs524023 0.874 rs475642 chr11:64424691 C/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.48 -0.5 2.17e-22 Urate levels in obese individuals; LUSC trans rs9291683 0.507 rs6827754 chr4:10018153 A/C cg26043149 chr18:55253948 FECH -0.55 -7.16 -0.36 5.11e-12 Bone mineral density; LUSC cis rs6700896 0.898 rs1938495 chr1:66106469 A/G cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.36e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7178572 0.568 rs28584877 chr15:77599003 C/A cg22256960 chr15:77711686 NA 0.49 7.8 0.39 7.96e-14 Type 2 diabetes; LUSC cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg03453431 chr7:157225567 NA -0.55 -9.82 -0.47 3.7e-20 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs12579753 1.000 rs11115017 chr12:82176914 C/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.07 -0.32 3.42e-9 Resting heart rate; LUSC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg07507251 chr3:52567010 NT5DC2 0.31 6.21 0.32 1.6e-9 Bipolar disorder; LUSC trans rs4295623 0.553 rs34962960 chr8:11594597 G/A cg27411982 chr8:10470053 RP1L1 -0.41 -6.48 -0.33 3.33e-10 Morning vs. evening chronotype; LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg12564285 chr5:131593104 PDLIM4 0.45 7.95 0.4 2.97e-14 Breast cancer; LUSC trans rs488628 0.798 rs504005 chr3:118138143 A/C cg06621744 chr14:37052470 NKX2-8 -0.3 -6.72 -0.35 7.68e-11 White matter integrity (bipolar disorder risk interaction); LUSC cis rs870825 0.616 rs4443323 chr4:185629805 C/A cg04058563 chr4:185651563 MLF1IP 0.88 12.53 0.57 8.92e-30 Blood protein levels; LUSC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg05368731 chr17:41323189 NBR1 -0.82 -13.96 -0.61 3.29e-35 Menopause (age at onset); LUSC trans rs8072100 0.935 rs8070759 chr17:45638760 C/T cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.2e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs796364 0.625 rs4673837 chr2:201131159 A/G cg23649088 chr2:200775458 C2orf69 0.52 6.79 0.35 5.29e-11 Schizophrenia; LUSC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg15147215 chr3:52552868 STAB1 -0.3 -5.96 -0.31 6.55e-9 Bipolar disorder; LUSC trans rs11098499 0.657 rs71614442 chr4:120379346 C/T cg25214090 chr10:38739885 LOC399744 0.56 8.16 0.41 7.08e-15 Corneal astigmatism; LUSC cis rs9341808 0.718 rs2143887 chr6:80917287 T/C cg08355045 chr6:80787529 NA 0.58 10.2 0.49 1.97e-21 Sitting height ratio; LUSC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg01416388 chr22:39784598 NA -0.45 -7.51 -0.38 5.32e-13 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.04 15.66 0.65 8.17e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg22782873 chr19:19639568 YJEFN3 0.53 6.45 0.33 3.94e-10 Bipolar disorder; LUSC cis rs7246967 0.673 rs2885221 chr19:22839387 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.87 0.35 3.18e-11 Bronchopulmonary dysplasia; LUSC cis rs7561273 0.609 rs10200844 chr2:24293363 A/C cg06627628 chr2:24431161 ITSN2 -0.51 -6.83 -0.35 3.93e-11 Quantitative traits; LUSC trans rs7395662 0.504 rs11039701 chr11:48389838 A/G cg21153622 chr11:89784906 NA -0.39 -6.04 -0.31 4.16e-9 HDL cholesterol; LUSC cis rs5758511 0.680 rs1107554 chr22:42667594 C/G cg00645731 chr22:42541494 CYP2D7P1 0.57 10.06 0.48 5.53e-21 Birth weight; LUSC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs921665 0.831 rs7566188 chr2:3199057 C/T cg16434511 chr2:3151078 NA -0.61 -6.42 -0.33 4.8e-10 World class endurance athleticism; LUSC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg03433033 chr1:76189801 ACADM 0.8 12.65 0.57 3.02e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs500891 0.525 rs1170483 chr6:84038253 G/C cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.15e-14 Platelet-derived growth factor BB levels; LUSC cis rs1949733 1.000 rs2140337 chr4:8502112 A/G cg13073564 chr4:8508604 NA -0.49 -9.14 -0.45 6.1e-18 Response to antineoplastic agents; LUSC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs16937 0.686 rs3851285 chr1:205155753 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.52 0.34 2.67e-10 Schizophrenia; LUSC trans rs867371 0.820 rs7164362 chr15:82486742 C/G cg18393722 chr15:85113863 UBE2QP1 -0.42 -6.09 -0.32 3.17e-9 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg06008330 chr7:65541103 ASL -0.4 -6.22 -0.32 1.52e-9 Aortic root size; LUSC cis rs12815613 1.000 rs7961554 chr12:121400244 G/T cg02403541 chr12:121454288 C12orf43 0.46 5.86 0.31 1.13e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1178968 1.000 rs12534600 chr7:72762721 C/T cg25889504 chr7:72793014 NA -0.6 -7.8 -0.39 7.86e-14 Triglyceride levels; LUSC cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg23711669 chr6:146136114 FBXO30 0.75 13.38 0.59 5.42e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg24692254 chr21:30365293 RNF160 0.74 11.82 0.54 3.48e-27 Pancreatic cancer; LUSC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg11645453 chr3:52864694 ITIH4 0.34 8.07 0.4 1.26e-14 Electroencephalogram traits; LUSC cis rs10465746 0.967 rs12748268 chr1:84374438 T/C cg10977910 chr1:84465055 TTLL7 0.43 6.16 0.32 2.1e-9 Obesity-related traits; LUSC cis rs477692 1.000 rs4750759 chr10:131436603 G/A cg05714579 chr10:131428358 MGMT -0.47 -6.9 -0.35 2.62e-11 Response to temozolomide; LUSC cis rs12956009 0.583 rs11082575 chr18:44905068 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -6.39 -0.33 5.51e-10 Educational attainment (years of education); LUSC trans rs34421088 0.506 rs4841518 chr8:11145963 G/C cg15556689 chr8:8085844 FLJ10661 0.46 6.73 0.35 7.34e-11 Neuroticism; LUSC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg00310523 chr12:86230176 RASSF9 0.51 9.63 0.47 1.6e-19 Major depressive disorder; LUSC cis rs7267979 1.000 rs2257420 chr20:25275890 C/A cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6681460 0.649 rs1947083 chr1:67004801 G/A cg02459107 chr1:67143332 SGIP1 0.37 6.32 0.33 8.4e-10 Presence of antiphospholipid antibodies; LUSC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg05347473 chr6:146136440 FBXO30 -0.57 -9.76 -0.47 5.78e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg09034736 chr1:150693464 HORMAD1 0.51 7.42 0.38 9.6e-13 Tonsillectomy; LUSC cis rs2635047 0.811 rs17785419 chr18:44765469 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.4 -6.22 -0.32 1.52e-9 Educational attainment; LUSC cis rs1448094 0.967 rs2044617 chr12:86324089 T/C cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.31e-9 Major depressive disorder; LUSC trans rs2797160 1.000 rs983543 chr6:126005767 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.16e-10 Endometrial cancer; LUSC cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg17261708 chr5:176794207 RGS14 0.33 5.91 0.31 8.29e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs9815354 0.761 rs73083326 chr3:41927150 G/T cg03022575 chr3:42003672 ULK4 0.82 8.74 0.43 1.14e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4073582 0.595 rs708472 chr11:65930990 A/G cg14036092 chr11:66035641 RAB1B 0.41 5.81 0.3 1.49e-8 Gout; LUSC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg22532475 chr10:104410764 TRIM8 -0.3 -6.59 -0.34 1.7e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3741151 0.773 rs73542938 chr11:73103012 G/C cg17517138 chr11:73019481 ARHGEF17 1.03 8.66 0.43 1.99e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg15212455 chr7:39170539 POU6F2 0.62 10.76 0.51 2.29e-23 IgG glycosylation; LUSC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs3106136 0.967 rs12646184 chr4:95183216 A/G cg11021082 chr4:95130006 SMARCAD1 0.35 6.1 0.32 2.96e-9 Capecitabine sensitivity; LUSC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg16414030 chr3:133502952 NA -0.43 -6.72 -0.35 7.96e-11 Iron status biomarkers; LUSC cis rs243505 0.898 rs243544 chr7:148402710 T/A cg09806900 chr7:148480153 CUL1 -0.49 -6.93 -0.35 2.18e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11264799 0.765 rs67805319 chr1:157622853 G/A cg18268488 chr1:157545234 FCRL4 0.33 5.74 0.3 2.13e-8 IgA nephropathy; LUSC cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.82 0.43 6.31e-17 Menopause (age at onset); LUSC cis rs10992471 0.603 rs987553 chr9:95298694 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -6.97 -0.36 1.7e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2073300 1.000 rs12626013 chr20:23442215 G/A cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs7178572 0.568 rs1389436 chr15:77665848 G/T cg22256960 chr15:77711686 NA -0.51 -8.09 -0.4 1.11e-14 Type 2 diabetes; LUSC cis rs61935443 0.666 rs73218073 chr12:95314346 A/G cg21533806 chr12:95267307 NA 0.49 5.72 0.3 2.38e-8 Schizophrenia; LUSC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg11645453 chr3:52864694 ITIH4 -0.36 -8.36 -0.42 1.77e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1865760 0.623 rs12216125 chr6:25997458 C/T cg16482183 chr6:26056742 HIST1H1C 0.57 7.96 0.4 2.78e-14 Height; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07360250 chr5:176830358 F12 -0.4 -7.37 -0.37 1.39e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs11098499 0.955 rs13114751 chr4:120156617 G/A cg09307838 chr4:120376055 NA 0.69 10.01 0.48 8.32e-21 Corneal astigmatism; LUSC cis rs9611519 0.894 rs8136923 chr22:41470522 G/A cg13813247 chr22:41461852 NA -0.37 -6.59 -0.34 1.67e-10 Neuroticism; LUSC cis rs2898290 0.578 rs34163377 chr8:11450213 C/G cg21175976 chr8:11421337 BLK 0.38 6.42 0.33 4.66e-10 Systolic blood pressure; LUSC cis rs11166629 1.000 rs935119 chr8:135638353 C/T cg21672855 chr8:135614777 ZFAT -0.35 -5.73 -0.3 2.3e-8 Smoking quantity; LUSC cis rs9473147 0.571 rs9463335 chr6:47479136 G/A cg20196966 chr6:47445060 CD2AP 0.43 5.98 0.31 5.68e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg06108461 chr20:60628389 TAF4 -0.75 -12.43 -0.56 1.99e-29 Body mass index; LUSC cis rs12042938 0.600 rs823165 chr1:231769446 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.46 6.89 0.35 2.73e-11 Neuranatomic and neurocognitive phenotypes; LUSC cis rs11756438 0.572 rs2638550 chr6:118998481 C/G cg21191810 chr6:118973309 C6orf204 0.35 5.91 0.31 8.34e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 5.73 0.3 2.27e-8 Personality dimensions; LUSC cis rs9322817 0.653 rs9486002 chr6:105162823 A/G cg02098413 chr6:105308735 HACE1 -0.28 -5.79 -0.3 1.59e-8 Thyroid stimulating hormone; LUSC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg24578937 chr1:2090814 PRKCZ -0.45 -9.89 -0.48 2.11e-20 Height; LUSC cis rs9814567 1.000 rs6766897 chr3:134191303 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -12.6 -0.57 4.93e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11945232 1.000 rs28609242 chr4:88342497 T/C cg23841344 chr4:88312519 HSD17B11 -0.64 -9.88 -0.48 2.32e-20 Intelligence (multi-trait analysis); LUSC cis rs9549367 0.664 rs9549689 chr13:113848387 G/A cg00898013 chr13:113819073 PROZ -0.63 -8.82 -0.43 6.52e-17 Platelet distribution width; LUSC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg12963246 chr6:28129442 ZNF389 0.52 7.18 0.37 4.53e-12 Depression; LUSC cis rs708547 0.874 rs1614251 chr4:57891386 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.5 -6.46 -0.33 3.71e-10 Response to bleomycin (chromatid breaks); LUSC cis rs4792901 0.802 rs28532791 chr17:41589479 G/A cg22562494 chr17:41607896 ETV4 -0.32 -5.9 -0.31 8.99e-9 Dupuytren's disease; LUSC cis rs8114671 0.586 rs734111 chr20:33533736 A/C cg24642439 chr20:33292090 TP53INP2 0.43 6.13 0.32 2.54e-9 Height; LUSC cis rs7799006 0.929 rs35629140 chr7:2257171 G/C cg08027265 chr7:2291960 NA -0.45 -7.44 -0.38 8.77e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.43 7.44 0.38 8.54e-13 Electroencephalogram traits; LUSC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg09826364 chr7:158789723 NA -0.4 -6.12 -0.32 2.57e-9 Facial morphology (factor 20); LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.61 10.19 0.49 2.03e-21 Lymphocyte counts; LUSC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg00316803 chr15:76480434 C15orf27 -0.39 -6.67 -0.34 1.09e-10 Blood metabolite levels; LUSC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg06637938 chr14:75390232 RPS6KL1 0.54 8.65 0.43 2.23e-16 Height; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg17367996 chr5:130506478 LYRM7 0.39 6.24 0.32 1.32e-9 Schizophrenia; LUSC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg20503657 chr10:835505 NA 0.97 13.34 0.59 7.77e-33 Eosinophil percentage of granulocytes; LUSC cis rs7100689 0.577 rs10749560 chr10:82092801 G/T cg00277334 chr10:82204260 NA -0.58 -8.81 -0.43 7.06e-17 Post bronchodilator FEV1; LUSC cis rs10737909 1.000 rs10737909 chr1:15548636 A/C cg21012057 chr1:15538911 TMEM51 0.33 5.65 0.3 3.35e-8 Migraine; LUSC cis rs3785574 0.536 rs2854190 chr17:61960219 G/A cg11494091 chr17:61959527 GH2 0.39 6.67 0.34 1.07e-10 Height; LUSC trans rs11098499 0.913 rs10006304 chr4:120124305 A/G cg25214090 chr10:38739885 LOC399744 0.44 6.28 0.32 1.04e-9 Corneal astigmatism; LUSC cis rs17125944 0.505 rs77137752 chr14:53230496 G/T cg13660082 chr14:53194042 PSMC6 -0.78 -6.81 -0.35 4.55e-11 Alzheimer's disease (late onset); LUSC cis rs72634258 0.945 rs2294889 chr1:8075934 A/G cg00042356 chr1:8021962 PARK7 0.72 9.39 0.46 9.92e-19 Inflammatory bowel disease; LUSC cis rs870825 0.616 rs28649620 chr4:185648997 G/A cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg06917634 chr15:78832804 PSMA4 -0.8 -13.93 -0.61 4.36e-35 Sudden cardiac arrest; LUSC cis rs34638657 0.732 rs12595971 chr16:82200309 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.44 -0.33 4.11e-10 Lung adenocarcinoma; LUSC cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg00049323 chr5:472564 LOC25845 0.49 7.75 0.39 1.08e-13 Cystic fibrosis severity; LUSC cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg21466736 chr12:48725269 NA 0.33 5.93 0.31 7.77e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.42 0.69 8.19e-49 Chronic sinus infection; LUSC cis rs11030122 0.702 rs10835340 chr11:3960420 A/G cg18678763 chr11:4115507 RRM1 0.46 5.98 0.31 5.62e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg05855489 chr10:104503620 C10orf26 0.65 9.77 0.47 5.21e-20 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6430585 0.878 rs9677760 chr2:136538939 T/A cg07169764 chr2:136633963 MCM6 -0.85 -11.91 -0.55 1.72e-27 Corneal structure; LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.94 12.96 0.58 2.18e-31 Platelet count; LUSC cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs5750830 0.594 rs5757647 chr22:39775047 C/A cg11247378 chr22:39784982 NA -0.64 -12.57 -0.57 6.06e-30 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg03929089 chr4:120376271 NA 0.94 15.01 0.63 2.7e-39 Coronary artery disease; LUSC cis rs185694 1.000 rs846495 chr13:30894250 T/C cg07600127 chr13:30881527 KATNAL1 -0.54 -5.9 -0.31 8.68e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; LUSC cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg08975724 chr8:8085496 FLJ10661 0.55 8.5 0.42 6.3e-16 Mood instability; LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg16524733 chr11:117070046 TAGLN 0.43 7.52 0.38 5.14e-13 Blood protein levels; LUSC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg04315214 chr1:2043799 PRKCZ 0.48 10.04 0.48 6.84e-21 Height; LUSC cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg23173402 chr1:227635558 NA 0.57 7.08 0.36 8.35e-12 Major depressive disorder; LUSC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.04 -0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC trans rs9388451 0.839 rs9401845 chr6:126104118 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.34 -0.46 1.38e-18 Brugada syndrome; LUSC cis rs11758351 1.000 rs79264785 chr6:26194121 C/T cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg18252515 chr7:66147081 NA -1.19 -12.84 -0.57 5.85e-31 Diabetic kidney disease; LUSC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg23887609 chr12:130822674 PIWIL1 0.48 7.1 0.36 7.75e-12 Menopause (age at onset); LUSC cis rs877426 0.515 rs57506460 chr13:114767789 G/A cg02745494 chr13:114771098 RASA3 0.34 5.7 0.3 2.63e-8 Facial morphology (factor 14, intercanthal width); LUSC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg22535103 chr8:58192502 C8orf71 -0.73 -9.31 -0.45 1.73e-18 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg06238570 chr21:40685208 BRWD1 0.47 7.25 0.37 2.84e-12 Cognitive function; LUSC cis rs4594175 0.707 rs12432912 chr14:51739395 T/C cg23942311 chr14:51606299 NA 0.3 6.01 0.31 4.87e-9 Cancer; LUSC cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg11266682 chr4:10021025 SLC2A9 -0.54 -9.96 -0.48 1.27e-20 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1008375 0.966 rs1860591 chr4:17577329 A/G cg18681998 chr4:17616180 MED28 0.82 14.9 0.63 7.75e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs208520 1.000 rs12200490 chr6:66976084 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 12.61 0.57 4.32e-30 Exhaled nitric oxide output; LUSC cis rs11631955 1 rs11631955 chr15:79085915 A/G cg00540400 chr15:79124168 NA -0.43 -7.56 -0.38 3.82e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -0.95 -14.23 -0.61 3.05e-36 Platelet count; LUSC cis rs9921338 0.961 rs11074958 chr16:11397079 C/T cg00044050 chr16:11439710 C16orf75 -0.48 -6.51 -0.34 2.73e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -7.96 -0.4 2.63e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs13401104 0.796 rs12471212 chr2:237112191 G/C cg19324714 chr2:237145437 ASB18 0.43 5.71 0.3 2.46e-8 Educational attainment; LUSC trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.14 -0.41 8.1e-15 Triglycerides; LUSC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.9 14.96 0.63 4.37e-39 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs3737883 1.000 rs4950913 chr1:203032153 A/G cg00805880 chr1:203045044 PPFIA4 -0.29 -5.81 -0.3 1.43e-8 Early onset atrial fibrillation; LUSC cis rs3768617 0.510 rs10911243 chr1:183075415 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.81 0.51 1.45e-23 Fuchs's corneal dystrophy; LUSC cis rs477692 0.699 rs576175 chr10:131386408 A/T cg05714579 chr10:131428358 MGMT 0.44 6.29 0.33 9.88e-10 Response to temozolomide; LUSC cis rs7246967 0.673 rs60675447 chr19:22810892 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.33 0.33 7.68e-10 Bronchopulmonary dysplasia; LUSC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg04248312 chr19:17393744 ANKLE1 -1.0 -16.97 -0.68 5.14e-47 Systemic lupus erythematosus; LUSC cis rs2067615 0.579 rs12424114 chr12:107144328 A/G cg15890332 chr12:107067104 RFX4 0.34 6.18 0.32 1.88e-9 Heart rate; LUSC trans rs62103177 0.513 rs9945153 chr18:77598450 C/T cg05926928 chr17:57297772 GDPD1 1.47 18.48 0.71 4.97e-53 Opioid sensitivity; LUSC cis rs10791097 0.694 rs10160281 chr11:130742788 T/C cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs478607 0.831 rs11602411 chr11:64449223 A/G cg19131476 chr11:64387923 NRXN2 -0.34 -5.91 -0.31 8.35e-9 Urate levels; LUSC trans rs11098499 0.690 rs34818745 chr4:120257055 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.14 0.32 2.28e-9 Corneal astigmatism; LUSC cis rs6977660 0.714 rs12334001 chr7:19814399 T/C cg07541023 chr7:19748670 TWISTNB 0.66 7.21 0.37 3.71e-12 Thyroid stimulating hormone; LUSC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg11752832 chr7:134001865 SLC35B4 0.55 8.61 0.43 2.94e-16 Mean platelet volume; LUSC cis rs595982 0.559 rs73061643 chr19:49368151 A/G cg15549821 chr19:49342101 PLEKHA4 -0.59 -8.04 -0.4 1.6e-14 Red cell distribution width; LUSC cis rs1577917 1.000 rs12663651 chr6:86701655 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.31e-11 Response to antipsychotic treatment; LUSC cis rs3770081 1.000 rs3770089 chr2:86263815 C/G cg23655155 chr2:86332777 POLR1A;PTCD3 -0.95 -6.26 -0.32 1.19e-9 Facial emotion recognition (sad faces); LUSC trans rs8073060 0.586 rs7217533 chr17:34015876 A/G cg19694781 chr19:47549865 TMEM160 -1.13 -17.91 -0.7 9.52e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7189233 0.531 rs8045674 chr16:53509936 G/A cg09728985 chr16:53543985 NA -0.33 -6.18 -0.32 1.91e-9 Intelligence (multi-trait analysis); LUSC cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.7 -0.3 2.67e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs11148252 0.774 rs9536066 chr13:52983981 A/G cg02158880 chr13:53174818 NA 0.37 6.18 0.32 1.85e-9 Lewy body disease; LUSC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg19717773 chr7:2847554 GNA12 0.36 6.06 0.31 3.6e-9 Height; LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg08847533 chr14:75593920 NEK9 0.85 15.75 0.65 3.43e-42 Height; LUSC cis rs8072100 0.782 rs62074054 chr17:45771816 T/C cg08085267 chr17:45401833 C17orf57 -0.46 -6.69 -0.34 9.41e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg23630131 chr7:65973040 NA 0.21 5.84 0.3 1.24e-8 Aortic root size; LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.62 0.38 2.61e-13 Prudent dietary pattern; LUSC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg08773314 chr2:239334832 ASB1 0.38 6.92 0.35 2.28e-11 Multiple system atrophy; LUSC cis rs7666738 0.515 rs13131874 chr4:98779183 A/G cg17366294 chr4:99064904 C4orf37 0.56 8.94 0.44 2.61e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs3540 0.512 rs3862433 chr15:91076028 G/A cg22089800 chr15:90895588 ZNF774 -0.65 -10.23 -0.49 1.52e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12291552 chr3:167813648 GOLIM4 0.36 6.15 0.32 2.2e-9 Asthma; LUSC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.67 0.34 1.05e-10 Lung cancer; LUSC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg08280861 chr8:58055591 NA 0.52 5.73 0.3 2.21e-8 Developmental language disorder (linguistic errors); LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg08621418 chr6:79944414 HMGN3 0.48 6.11 0.32 2.83e-9 Thyroid stimulating hormone; LUSC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg17294928 chr15:75287854 SCAMP5 -0.83 -11.25 -0.52 4.02e-25 Blood trace element (Zn levels); LUSC trans rs3749237 0.964 rs11717463 chr3:49808981 C/T cg21659725 chr3:3221576 CRBN 0.6 7.73 0.39 1.24e-13 Resting heart rate; LUSC cis rs1577917 0.740 rs2758843 chr6:86328431 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.81 -0.39 7.24e-14 Response to antipsychotic treatment; LUSC cis rs7786877 0.582 rs2075674 chr7:100225031 G/A cg00334542 chr7:100209784 MOSPD3 -0.67 -7.39 -0.37 1.21e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 12.9 0.58 3.67e-31 Platelet count; LUSC cis rs8060686 0.641 rs113790673 chr16:68244347 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.39 -0.33 5.45e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7119167 0.901 rs11235746 chr11:73127168 T/G cg17517138 chr11:73019481 ARHGEF17 0.54 6.07 0.32 3.45e-9 Blood protein levels; LUSC cis rs912057 0.833 rs1294426 chr6:6744477 T/C cg06612196 chr6:6737390 NA 0.54 10.32 0.49 7.37e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC trans rs7937682 0.847 rs500163 chr11:111462649 T/G cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg00814883 chr7:100076585 TSC22D4 -0.69 -8.91 -0.44 3.42e-17 Platelet count; LUSC trans rs7824557 0.713 rs6601575 chr8:11097804 A/C cg06636001 chr8:8085503 FLJ10661 0.52 8.3 0.41 2.54e-15 Retinal vascular caliber; LUSC cis rs1215050 0.791 rs7681599 chr4:98664109 C/T cg05340658 chr4:99064831 C4orf37 -0.46 -7.27 -0.37 2.5e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg12564285 chr5:131593104 PDLIM4 0.43 7.86 0.4 5.33e-14 Breast cancer; LUSC cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.94 -0.44 2.61e-17 Monocyte percentage of white cells; LUSC cis rs3008870 1.000 rs6673462 chr1:67461857 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs13394619 0.605 rs12476319 chr2:11748406 A/G cg07314298 chr2:11723111 GREB1 0.42 7.22 0.37 3.51e-12 Endometriosis; LUSC cis rs854765 0.624 rs4925116 chr17:17731200 A/G cg09796270 chr17:17721594 SREBF1 -0.45 -7.95 -0.4 2.89e-14 Total body bone mineral density; LUSC cis rs3126085 0.935 rs10888470 chr1:152200472 T/C cg26876637 chr1:152193138 HRNR 0.45 6.29 0.33 9.81e-10 Atopic dermatitis; LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.78 -0.43 8.36e-17 Bipolar disorder; LUSC cis rs6967385 0.867 rs2216046 chr7:12360630 G/A cg06484146 chr7:12443880 VWDE 0.38 5.7 0.3 2.68e-8 Response to taxane treatment (placlitaxel); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26342398 chr1:85156326 SSX2IP -0.47 -5.99 -0.31 5.29e-9 Bipolar disorder and schizophrenia; LUSC trans rs6076960 0.811 rs6053960 chr20:6176778 T/C cg21095983 chr6:86352623 SYNCRIP 0.41 6.34 0.33 7.38e-10 Smooth-surface caries; LUSC cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.51 -0.38 5.54e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10484885 0.824 rs28372875 chr6:90529343 C/T cg13799429 chr6:90582589 CASP8AP2 -0.84 -7.84 -0.39 6.09e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9486719 1.000 rs4077932 chr6:96905144 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs7829975 0.514 rs2976926 chr8:8261624 T/C cg06636001 chr8:8085503 FLJ10661 0.67 11.26 0.52 3.8e-25 Mood instability; LUSC cis rs11971779 0.646 rs58682779 chr7:139084712 C/T cg07862535 chr7:139043722 LUC7L2 0.74 8.31 0.41 2.47e-15 Diisocyanate-induced asthma; LUSC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg13798912 chr7:905769 UNC84A -0.59 -6.06 -0.31 3.58e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs17685 0.753 rs10245584 chr7:75745866 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.69 -0.39 1.68e-13 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs2243480 0.901 rs57126451 chr7:65416306 T/C cg10756647 chr7:56101905 PSPH 0.86 8.62 0.43 2.8e-16 Diabetic kidney disease; LUSC cis rs7089973 0.604 rs11196936 chr10:116588630 C/T cg03647239 chr10:116582469 FAM160B1 0.45 7.27 0.37 2.55e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7647973 0.922 rs7620024 chr3:49451691 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.46 -6.8 -0.35 4.83e-11 Menarche (age at onset); LUSC cis rs9902453 0.765 rs2250320 chr17:28128657 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -11.67 -0.54 1.29e-26 Coffee consumption (cups per day); LUSC trans rs9747201 0.962 rs34016823 chr17:80095428 G/T cg07393940 chr7:158741817 NA -0.51 -8.2 -0.41 5.29e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs11723530 0.538 rs6855275 chr4:170809649 C/T cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.2 -0.32 1.62e-9 Myopia (pathological); LUSC cis rs7769051 0.522 rs34688576 chr6:133118214 C/T cg07930552 chr6:133119739 C6orf192 0.94 8.39 0.42 1.41e-15 Type 2 diabetes nephropathy; LUSC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11644478 chr21:40555479 PSMG1 -0.66 -10.28 -0.49 1.04e-21 Menarche (age at onset); LUSC cis rs3806843 0.966 rs10060640 chr5:140211226 G/A cg19875535 chr5:140030758 IK 0.48 7.76 0.39 1.01e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg11645453 chr3:52864694 ITIH4 0.35 8.14 0.41 7.76e-15 Bipolar disorder; LUSC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.73 0.39 1.26e-13 Bipolar disorder; LUSC cis rs17092148 1.000 rs6060025 chr20:33326876 A/G cg16810054 chr20:33298113 TP53INP2 -0.41 -6.47 -0.33 3.42e-10 Neuroticism; LUSC trans rs7647973 0.626 rs4855849 chr3:49653378 A/G cg16286249 chr1:33625400 TRIM62 0.5 6.06 0.31 3.68e-9 Menarche (age at onset); LUSC cis rs9549367 0.789 rs9604040 chr13:113910611 A/G cg18105134 chr13:113819100 PROZ 0.62 9.07 0.44 1.03e-17 Platelet distribution width; LUSC cis rs2200578 0.841 rs62154623 chr2:99611488 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.55 6.61 0.34 1.49e-10 IgG glycosylation; LUSC cis rs6459788 0.934 rs10251462 chr7:157258183 C/G cg03453431 chr7:157225567 NA -0.51 -8.47 -0.42 7.93e-16 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs897080 0.515 rs786617 chr2:44593158 G/A cg00619915 chr2:44497795 NA -0.41 -5.93 -0.31 7.72e-9 Height; LUSC cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg06784218 chr1:46089804 CCDC17 0.49 9.71 0.47 8.23e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg01570182 chr17:44337453 NA -0.7 -10.56 -0.5 1.09e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs5769765 0.908 rs56351880 chr22:50316597 A/G cg08270630 chr22:50330655 NA -0.45 -6.67 -0.34 1.07e-10 Schizophrenia; LUSC cis rs950169 0.580 rs35516100 chr15:85195430 C/T cg12863693 chr15:85201151 NMB 0.4 8.45 0.42 8.81e-16 Schizophrenia; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg14789911 chr21:47582049 C21orf56 0.4 6.27 0.32 1.14e-9 Testicular germ cell tumor; LUSC cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg12310025 chr6:25882481 NA -0.5 -9.07 -0.44 1.07e-17 Blood metabolite levels; LUSC cis rs7264396 0.887 rs6060442 chr20:34093757 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.62 -0.34 1.47e-10 Total cholesterol levels; LUSC cis rs9549260 0.785 rs6563842 chr13:41244297 G/T cg21288729 chr13:41239152 FOXO1 0.63 9.73 0.47 7.31e-20 Red blood cell count; LUSC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg22834771 chr12:69754056 YEATS4 -0.41 -5.65 -0.3 3.48e-8 Response to diuretic therapy; LUSC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg12365402 chr11:9010492 NRIP3 0.43 7.9 0.4 4.21e-14 Hemoglobin concentration; LUSC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg21138405 chr5:131827807 IRF1 -0.33 -5.81 -0.3 1.45e-8 Breast cancer;Mosquito bite size; LUSC cis rs477692 0.935 rs554458 chr10:131427372 A/G cg26102564 chr10:131424627 MGMT 0.38 6.0 0.31 5.11e-9 Response to temozolomide; LUSC cis rs8040855 0.644 rs4635318 chr15:85726737 C/A cg04831495 chr15:85060580 GOLGA6L5 0.41 6.54 0.34 2.34e-10 Bulimia nervosa; LUSC trans rs6951245 1.000 rs75488469 chr7:1102122 A/G cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4474465 1.000 rs11237514 chr11:78180179 A/G cg27205649 chr11:78285834 NARS2 -0.53 -6.13 -0.32 2.49e-9 Alzheimer's disease (survival time); LUSC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.0 0.4 2.11e-14 Melanoma; LUSC cis rs6964587 1.000 rs12531366 chr7:91683849 C/G cg22709100 chr7:91322751 NA 0.39 5.81 0.3 1.48e-8 Breast cancer; LUSC cis rs2274273 1.000 rs67805055 chr14:55587552 C/T cg04306507 chr14:55594613 LGALS3 0.53 11.43 0.53 9.65e-26 Protein biomarker; LUSC cis rs10193935 0.605 rs10169492 chr2:42401961 G/T cg27598129 chr2:42591480 NA -0.62 -8.15 -0.41 7.49e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7809950 1.000 rs2066735 chr7:107188719 G/T cg23024343 chr7:107201750 COG5 -0.54 -8.65 -0.43 2.14e-16 Coronary artery disease; LUSC cis rs7523273 0.606 rs2796283 chr1:207978732 C/T cg22525895 chr1:207977042 MIR29B2 -0.4 -6.39 -0.33 5.42e-10 Schizophrenia; LUSC cis rs11098499 0.775 rs2002049 chr4:120257417 A/G cg24375607 chr4:120327624 NA 0.77 12.51 0.56 1.08e-29 Corneal astigmatism; LUSC cis rs35417517 1 rs35417517 chr7:91772730 CG/C cg01689657 chr7:91764605 CYP51A1 0.32 5.89 0.31 9.34e-9 Breast cancer; LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.7 -0.43 1.57e-16 Bipolar disorder; LUSC cis rs10751667 0.643 rs7396407 chr11:929374 A/T ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs16912285 0.688 rs7126291 chr11:24312936 A/C ch.11.24196551F chr11:24239977 NA 0.9 9.61 0.47 1.78e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9467773 0.935 rs1056668 chr6:26510605 C/T cg05738196 chr6:26577821 NA 0.75 13.11 0.58 5.56e-32 Intelligence (multi-trait analysis); LUSC cis rs2354432 0.556 rs11239965 chr1:146753907 C/A cg25205988 chr1:146714368 CHD1L -1.04 -9.38 -0.46 1.05e-18 Mitochondrial DNA levels; LUSC cis rs6429082 0.783 rs291364 chr1:235687179 A/G cg26050004 chr1:235667680 B3GALNT2 0.66 9.44 0.46 6.8e-19 Adiposity; LUSC cis rs8017423 0.967 rs61592400 chr14:90703252 T/C cg14092571 chr14:90743983 NA -0.35 -5.66 -0.3 3.27e-8 Mortality in heart failure; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11461694 chr4:103266404 SLC39A8 -0.42 -6.23 -0.32 1.43e-9 Hepatitis; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.82 -0.39 6.83e-14 Lymphocyte counts; LUSC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg24060327 chr5:131705240 SLC22A5 0.68 11.39 0.53 1.26e-25 Breast cancer; LUSC cis rs2439831 0.681 rs825739 chr15:43592428 T/G cg02155558 chr15:43621948 ADAL;LCMT2 1.06 14.95 0.63 4.68e-39 Lung cancer in ever smokers; LUSC cis rs4722585 0.605 rs3753098 chr7:26198040 C/T cg07876897 chr7:26191696 NFE2L3 -0.46 -7.06 -0.36 9.95e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs600231 0.577 rs35826299 chr11:65240964 T/C cg17120908 chr11:65337727 SSSCA1 -0.62 -8.95 -0.44 2.47e-17 Bone mineral density; LUSC trans rs6502050 0.865 rs8079388 chr17:80162798 C/A cg07393940 chr7:158741817 NA 0.36 6.4 0.33 5.36e-10 Life satisfaction; LUSC cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg23711669 chr6:146136114 FBXO30 0.72 12.88 0.58 4.13e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs500891 0.553 rs7744602 chr6:84127591 C/T cg08257003 chr6:84140564 ME1 0.36 8.73 0.43 1.27e-16 Platelet-derived growth factor BB levels; LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg03188948 chr7:1209495 NA 0.67 7.1 0.36 7.38e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs2952768 0.965 rs2551640 chr2:208407893 G/A cg22739477 chr2:208394512 CREB1 0.36 5.82 0.3 1.39e-8 Opioid sensitivity; LUSC cis rs7180079 1.000 rs77627789 chr15:64444276 G/C cg08069370 chr15:64387884 SNX1 -0.71 -6.98 -0.36 1.59e-11 Monocyte count; LUSC cis rs9527 0.590 rs7906754 chr10:104782557 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.83 0.47 3.35e-20 Arsenic metabolism; LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg22535103 chr8:58192502 C8orf71 -0.65 -7.33 -0.37 1.7e-12 Developmental language disorder (linguistic errors); LUSC cis rs6484504 0.576 rs208066 chr11:31156206 C/G cg06552810 chr11:31128660 NA -0.41 -7.33 -0.37 1.76e-12 Red blood cell count; LUSC cis rs9467773 1.000 rs9467787 chr6:26556769 G/T cg05738196 chr6:26577821 NA 0.83 16.17 0.66 7.5e-44 Intelligence (multi-trait analysis); LUSC cis rs9420 0.961 rs7938083 chr11:57493622 C/A cg23127183 chr11:57508653 C11orf31 -0.63 -9.44 -0.46 6.64e-19 Schizophrenia; LUSC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg17845761 chr1:175162550 KIAA0040 -0.31 -6.01 -0.31 4.99e-9 Alcohol dependence; LUSC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg18654377 chr3:49208889 KLHDC8B -0.46 -5.96 -0.31 6.51e-9 Menarche (age at onset); LUSC cis rs11214589 0.747 rs11214577 chr11:113204266 A/G cg14159747 chr11:113255604 NA -0.27 -6.76 -0.35 6.11e-11 Neuroticism; LUSC cis rs10489202 1.000 rs12404574 chr1:167961235 C/T cg24449463 chr1:168025552 DCAF6 0.57 7.52 0.38 5e-13 Schizophrenia; LUSC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg11764359 chr7:65958608 NA 0.65 6.35 0.33 6.97e-10 Diabetic kidney disease; LUSC cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06544989 chr22:39130855 UNC84B 0.33 5.66 0.3 3.28e-8 Menopause (age at onset); LUSC cis rs1371867 0.846 rs1660323 chr8:101278724 T/A cg06636551 chr8:101224915 SPAG1 -0.43 -7.92 -0.4 3.51e-14 Atrioventricular conduction; LUSC cis rs2806561 0.765 rs9426692 chr1:23508426 C/T cg12483005 chr1:23474871 LUZP1 0.42 6.45 0.33 3.98e-10 Height; LUSC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg02423579 chr7:2872169 GNA12 -0.39 -5.81 -0.3 1.49e-8 Height; LUSC cis rs804280 0.525 rs1004712 chr8:11622293 C/T cg12395012 chr8:11607386 GATA4 -0.35 -5.81 -0.3 1.48e-8 Myopia (pathological); LUSC cis rs1994135 0.692 rs7958788 chr12:33692179 T/C cg06521331 chr12:34319734 NA -0.39 -5.83 -0.3 1.32e-8 Resting heart rate; LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.08 -0.32 3.35e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9814567 0.806 rs1880374 chr3:134322113 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.33 -0.56 4.74e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs8141529 0.732 rs5762784 chr22:29171298 C/T cg15103426 chr22:29168792 CCDC117 0.55 7.52 0.38 5.21e-13 Lymphocyte counts; LUSC cis rs4654899 1.000 rs6426659 chr1:21361302 G/A cg01072550 chr1:21505969 NA -0.56 -8.54 -0.42 4.74e-16 Superior frontal gyrus grey matter volume; LUSC cis rs4474465 0.573 rs7101478 chr11:78272517 C/A cg27205649 chr11:78285834 NARS2 0.58 7.13 0.36 6.24e-12 Alzheimer's disease (survival time); LUSC cis rs67539049 0.891 rs73209223 chr8:11304944 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.41 -6.41 -0.33 5.04e-10 Itch intensity from mosquito bite; LUSC cis rs77633900 0.772 rs2957612 chr15:76703688 C/T cg21673338 chr15:77095150 SCAPER -0.7 -5.99 -0.31 5.4e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg04369109 chr6:150039330 LATS1 -0.54 -7.45 -0.38 8.03e-13 Lung cancer; LUSC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.06 -0.31 3.71e-9 Life satisfaction; LUSC cis rs9611565 0.532 rs4401299 chr22:42156517 A/G cg03806693 chr22:41940476 POLR3H 0.84 12.06 0.55 4.75e-28 Vitiligo; LUSC cis rs4803468 0.967 rs11670583 chr19:41920440 A/T cg09537434 chr19:41945824 ATP5SL -0.92 -15.94 -0.66 6.34e-43 Height; LUSC trans rs4957048 0.891 rs11960196 chr5:568857 C/A cg25482853 chr8:67687455 SGK3 1.02 15.96 0.66 5.27e-43 Ulcerative colitis; LUSC cis rs7267979 0.586 rs1473695 chr20:25186965 A/G cg08601574 chr20:25228251 PYGB 0.44 6.71 0.34 8.25e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg13319975 chr6:146136371 FBXO30 0.51 7.68 0.39 1.74e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs8060686 0.516 rs1971546 chr16:68280893 T/C cg09835421 chr16:68378352 PRMT7 -0.51 -6.28 -0.32 1.06e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6598955 0.627 rs6684875 chr1:26567044 A/G cg00852783 chr1:26633632 UBXN11 -0.49 -5.8 -0.3 1.52e-8 Obesity-related traits; LUSC cis rs34779708 0.736 rs34195979 chr10:35549817 T/C cg03585969 chr10:35415529 CREM 0.52 7.09 0.36 8.09e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8078723 1.000 rs4795416 chr17:38158133 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.82 -0.35 4.38e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs6121246 0.567 rs6058197 chr20:30194899 A/G cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.06e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.95 0.36 1.89e-11 Hip circumference adjusted for BMI; LUSC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg18479299 chr3:125709523 NA -0.51 -5.8 -0.3 1.55e-8 Blood pressure (smoking interaction); LUSC cis rs6121246 0.567 rs6060261 chr20:30192948 C/G cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg08677398 chr8:58056175 NA 0.51 6.15 0.32 2.19e-9 Developmental language disorder (linguistic errors); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26930643 chr1:48463304 NA -0.48 -6.37 -0.33 6.15e-10 Hepatitis; LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.16 -0.36 5.11e-12 Menopause (age at onset); LUSC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg13939156 chr17:80058883 NA 0.34 6.74 0.35 7.09e-11 Life satisfaction; LUSC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg04317338 chr11:64019027 PLCB3 0.67 7.64 0.39 2.25e-13 Mean platelet volume; LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.53 6.61 0.34 1.55e-10 Renal function-related traits (BUN); LUSC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC cis rs11958404 0.932 rs72816574 chr5:157429882 T/C cg05962755 chr5:157440814 NA 0.54 6.34 0.33 7.29e-10 IgG glycosylation; LUSC cis rs6942756 0.876 rs1559486 chr7:129015894 C/T cg02491457 chr7:128862824 NA -0.41 -5.95 -0.31 6.71e-9 White matter hyperintensity burden; LUSC trans rs7944735 0.817 rs747782 chr11:47940925 A/G cg15704280 chr7:45808275 SEPT13 0.6 6.49 0.33 3.13e-10 Intraocular pressure; LUSC cis rs2250402 0.510 rs2291619 chr15:40329033 C/T cg10636054 chr15:40330586 SRP14 -0.92 -8.81 -0.43 6.95e-17 Corneal curvature; LUSC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg26597838 chr10:835615 NA 0.99 14.06 0.61 1.39e-35 Eosinophil percentage of granulocytes; LUSC cis rs2979489 0.891 rs2915594 chr8:30401367 T/C cg26383811 chr8:30366931 RBPMS -0.51 -8.13 -0.41 8.49e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs981844 1.000 rs55722886 chr4:154668335 A/G cg14289246 chr4:154710475 SFRP2 0.48 6.1 0.32 2.87e-9 Response to statins (LDL cholesterol change); LUSC cis rs6835098 0.924 rs1991727 chr4:174163169 A/G cg08422745 chr4:174089978 GALNT7 -0.74 -12.57 -0.57 6.41e-30 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs35000415 0.873 rs12539741 chr7:128596805 C/T cg19972273 chr7:128594194 NA 0.67 6.79 0.35 5.17e-11 Systemic lupus erythematosus; LUSC cis rs4654899 0.549 rs4654873 chr1:21152384 G/A cg01072550 chr1:21505969 NA -0.46 -6.84 -0.35 3.68e-11 Superior frontal gyrus grey matter volume; LUSC cis rs6960043 0.748 rs10228561 chr7:15063961 C/T cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC trans rs853679 0.607 rs35345226 chr6:28091580 A/G cg06606381 chr12:133084897 FBRSL1 -1.04 -8.89 -0.44 3.79e-17 Depression; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03258011 chr17:54857409 NA 0.39 5.98 0.31 5.65e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg13736514 chr6:26305472 NA -0.45 -8.94 -0.44 2.72e-17 Educational attainment; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.89 0.35 2.81e-11 Tonsillectomy; LUSC cis rs6121246 0.529 rs6060118 chr20:30171209 T/C cg18721089 chr20:30220636 NA -0.44 -7.06 -0.36 9.51e-12 Mean corpuscular hemoglobin; LUSC cis rs6736093 0.966 rs11687451 chr2:112682561 G/A cg12686935 chr2:112915763 FBLN7 -0.36 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs56399783 0.901 rs73047387 chr7:2774125 G/A cg19731401 chr7:2775893 GNA12 0.74 8.97 0.44 2.17e-17 Childhood ear infection; LUSC cis rs2944755 1.000 rs2944755 chr8:141574194 A/G cg08444833 chr8:141574162 EIF2C2 0.47 6.05 0.31 3.79e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs5758659 0.716 rs2143138 chr22:42618340 T/C cg00645731 chr22:42541494 CYP2D7P1 -0.31 -6.52 -0.34 2.65e-10 Cognitive function; LUSC cis rs965469 0.947 rs6037529 chr20:3261006 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -5.8 -0.3 1.57e-8 IFN-related cytopenia; LUSC cis rs8017423 0.967 rs4904662 chr14:90729427 G/A cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC trans rs62103177 0.810 rs62103195 chr18:77629693 T/C cg14227996 chr4:17616232 MED28 0.83 7.96 0.4 2.69e-14 Opioid sensitivity; LUSC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.3 0.56 6.13e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34734847 0.703 rs3794215 chr12:121168083 T/C cg21892295 chr12:121157589 UNC119B -0.33 -5.79 -0.3 1.65e-8 Mean corpuscular volume; LUSC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg21194808 chr1:2205498 SKI 0.37 5.96 0.31 6.49e-9 Coronary artery disease; LUSC cis rs9296092 0.560 rs17627049 chr6:33537802 G/T cg13560919 chr6:33536144 NA -0.86 -16.5 -0.67 3.69e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs17270561 0.636 rs9379782 chr6:25715023 G/A cg17691542 chr6:26056736 HIST1H1C 0.6 8.12 0.41 9.15e-15 Iron status biomarkers; LUSC cis rs9467773 0.620 rs2101581 chr6:26622769 G/T cg05738196 chr6:26577821 NA 0.79 15.22 0.64 4.38e-40 Intelligence (multi-trait analysis); LUSC cis rs1048238 0.506 rs698890 chr1:16267371 C/G cg21385522 chr1:16154831 NA -0.53 -8.37 -0.42 1.55e-15 Systolic blood pressure; LUSC cis rs9650315 0.866 rs55752715 chr8:57196353 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.6 7.48 0.38 6.82e-13 Height; LUSC cis rs7903847 0.642 rs3814553 chr10:99155984 G/A cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs4663866 1.000 rs6741269 chr2:239179418 A/G cg16914508 chr2:239161102 PER2 0.68 7.15 0.36 5.4e-12 Irritable bowel syndrome; LUSC cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.9 0.4 3.95e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs147120681 1 rs147120681 chr1:101239293 CT/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.39 -5.65 -0.3 3.37e-8 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs12980942 1.000 rs2241719 chr19:41829581 T/A cg25627403 chr19:41769009 HNRNPUL1 0.57 6.14 0.32 2.37e-9 Coronary artery disease; LUSC cis rs56283067 0.847 rs12204270 chr6:44697502 A/T cg20913747 chr6:44695427 NA -0.48 -7.93 -0.4 3.41e-14 Total body bone mineral density; LUSC cis rs2625529 0.824 rs1074330 chr15:72250741 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.44 -0.38 8.62e-13 Red blood cell count; LUSC cis rs17286411 0.669 rs4788547 chr16:71634544 G/A cg10085824 chr16:71800315 AP1G1 0.35 5.71 0.3 2.47e-8 Blood protein levels; LUSC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg22508957 chr16:3507546 NAT15 -0.68 -11.39 -0.53 1.25e-25 Tuberculosis; LUSC cis rs34375054 0.624 rs12832525 chr12:125680366 T/C cg25124228 chr12:125621409 AACS -0.4 -5.7 -0.3 2.65e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs701145 0.556 rs355756 chr3:154021063 G/A cg17054900 chr3:154042577 DHX36 0.43 5.65 0.3 3.52e-8 Coronary artery disease; LUSC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg22467129 chr15:76604101 ETFA -0.43 -6.96 -0.36 1.84e-11 Blood metabolite levels; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.48 5.76 0.3 1.96e-8 Renal function-related traits (BUN); LUSC cis rs977987 0.872 rs4888422 chr16:75470576 A/G cg03315344 chr16:75512273 CHST6 0.52 10.35 0.49 5.68e-22 Dupuytren's disease; LUSC cis rs4964805 0.641 rs11111755 chr12:104159667 G/A cg02344784 chr12:104178138 NT5DC3 0.37 5.96 0.31 6.51e-9 Attention deficit hyperactivity disorder; LUSC cis rs7809950 0.954 rs2520241 chr7:107135443 A/G cg23024343 chr7:107201750 COG5 -0.55 -8.99 -0.44 1.88e-17 Coronary artery disease; LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg09436375 chr6:42928200 GNMT 0.28 6.69 0.34 9.49e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs10782582 0.593 rs6675076 chr1:76118503 A/C cg10523679 chr1:76189770 ACADM -0.49 -7.28 -0.37 2.36e-12 Daytime sleep phenotypes; LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.32 0.37 1.91e-12 Gut microbiome composition (summer); LUSC cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg07395648 chr5:131743802 NA 0.43 6.22 0.32 1.45e-9 Blood metabolite levels; LUSC cis rs2073300 1.000 rs6137961 chr20:23443102 G/T cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25581826 chr20:2821485 FAM113A;VPS16 0.66 6.14 0.32 2.4e-9 Cognitive performance; LUSC cis rs262150 0.546 rs7798337 chr7:158801089 G/A cg23096020 chr7:158799433 NA 0.36 6.09 0.32 3.05e-9 Facial morphology (factor 20); LUSC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg11812906 chr14:75593930 NEK9 -0.64 -10.55 -0.5 1.16e-22 Height; LUSC cis rs3862030 0.839 rs7078511 chr10:104283874 C/A cg05855489 chr10:104503620 C10orf26 0.5 7.5 0.38 5.98e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg04267008 chr7:1944627 MAD1L1 -0.45 -6.6 -0.34 1.66e-10 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg11494091 chr17:61959527 GH2 0.64 13.66 0.6 4.76e-34 Prudent dietary pattern; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg09436375 chr6:42928200 GNMT -0.25 -5.73 -0.3 2.25e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg14403583 chr14:105418241 AHNAK2 -0.54 -9.03 -0.44 1.44e-17 Rheumatoid arthritis; LUSC trans rs2898290 0.622 rs11250140 chr8:11346592 A/C cg06636001 chr8:8085503 FLJ10661 -0.55 -8.58 -0.42 3.56e-16 Systolic blood pressure; LUSC cis rs2050392 0.767 rs10763787 chr10:30700753 G/A cg25182066 chr10:30743637 MAP3K8 0.44 6.16 0.32 2.13e-9 Inflammatory bowel disease; LUSC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg13319975 chr6:146136371 FBXO30 -0.69 -10.69 -0.5 3.9699999999999997e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs17270561 0.609 rs4145216 chr6:25743559 G/A cg16482183 chr6:26056742 HIST1H1C 0.63 9.07 0.44 1.01e-17 Iron status biomarkers; LUSC cis rs10791097 0.739 rs4936120 chr11:130723452 G/A cg12179176 chr11:130786555 SNX19 0.76 11.98 0.55 9.75e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6987853 0.583 rs2974311 chr8:42455166 G/A cg09913449 chr8:42400586 C8orf40 0.38 6.05 0.31 3.83e-9 Mean corpuscular hemoglobin concentration; LUSC cis rs34172651 0.917 rs200532 chr16:24756148 C/T cg00339695 chr16:24857497 SLC5A11 -0.38 -6.71 -0.34 8.22e-11 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15342139 chr6:170124938 PHF10 -0.5 -6.38 -0.33 5.95e-10 Bipolar disorder and schizophrenia; LUSC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg09034736 chr1:150693464 HORMAD1 0.5 7.3 0.37 2.18e-12 Tonsillectomy; LUSC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg14004847 chr7:1930337 MAD1L1 -0.53 -8.03 -0.4 1.63e-14 Bipolar disorder and schizophrenia; LUSC cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg24642439 chr20:33292090 TP53INP2 0.51 7.64 0.39 2.32e-13 Height; LUSC cis rs4919694 1.000 rs58700372 chr10:104800205 T/C cg04362960 chr10:104952993 NT5C2 1.18 13.88 0.6 7.01e-35 Arsenic metabolism; LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg14092988 chr3:52407081 DNAH1 0.3 5.81 0.3 1.46e-8 Bipolar disorder; LUSC cis rs1009647 0.645 rs68153899 chr14:55702908 C/T cg04306507 chr14:55594613 LGALS3 0.42 5.64 0.3 3.56e-8 Testicular germ cell tumor; LUSC cis rs8114671 0.967 rs2378337 chr20:33771435 G/A cg24642439 chr20:33292090 TP53INP2 0.41 5.93 0.31 7.42e-9 Height; LUSC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg13395646 chr4:1353034 KIAA1530 -0.64 -10.08 -0.48 4.83e-21 Obesity-related traits; LUSC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg21433313 chr16:3507492 NAT15 -0.7 -8.62 -0.43 2.8e-16 Tuberculosis; LUSC cis rs8062405 0.655 rs7184597 chr16:28921809 T/C cg05966235 chr16:28915196 ATP2A1 -0.35 -5.89 -0.31 9.2e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg01097406 chr16:89675127 NA 0.36 7.32 0.37 1.84e-12 Vitiligo; LUSC cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.46 -0.46 5.58e-19 Schizophrenia; LUSC cis rs1864400 0.645 rs2249005 chr10:43627280 A/G cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.16e-11 Hirschsprung disease; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.23 0.56 1.17e-28 Prudent dietary pattern; LUSC cis rs1371867 0.875 rs2439456 chr8:101336874 C/T cg06002616 chr8:101225028 SPAG1 -0.42 -7.0 -0.36 1.39e-11 Atrioventricular conduction; LUSC cis rs72781680 1.000 rs7581107 chr2:24173565 C/T cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC trans rs17807624 1.000 rs17807624 chr8:11463015 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.76 -0.35 6.03e-11 Systemic lupus erythematosus; LUSC cis rs7247513 0.964 rs8100964 chr19:12720631 C/T cg01871581 chr19:12707946 ZNF490 -0.52 -8.01 -0.4 1.91e-14 Bipolar disorder; LUSC cis rs6580649 1.000 rs9805048 chr12:48403692 C/T cg24011408 chr12:48396354 COL2A1 0.54 7.6 0.38 3.09e-13 Lung cancer; LUSC trans rs7726839 0.561 rs4957048 chr5:583442 G/A cg11887960 chr12:57824829 NA 0.48 6.47 0.33 3.46e-10 Obesity-related traits; LUSC cis rs73206853 0.688 rs73191809 chr12:110907639 T/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg17143192 chr8:8559678 CLDN23 0.67 9.7 0.47 9.24e-20 Obesity-related traits; LUSC cis rs55871839 0.708 rs13268621 chr8:59811724 T/G cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg21153622 chr11:89784906 NA -0.39 -6.14 -0.32 2.29e-9 HDL cholesterol; LUSC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7131987 0.621 rs3782506 chr12:29445422 A/C cg09582351 chr12:29534625 ERGIC2 0.34 6.94 0.36 2.03e-11 QT interval; LUSC cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg27446573 chr6:127587934 RNF146 0.69 10.56 0.5 1.09e-22 Breast cancer; LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg18099408 chr3:52552593 STAB1 -0.4 -6.92 -0.35 2.26e-11 Bipolar disorder; LUSC cis rs7666738 0.546 rs11727151 chr4:98837353 A/C cg03676636 chr4:99064102 C4orf37 0.33 6.3 0.33 9.43e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs75920871 0.528 rs11216244 chr11:116912730 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.38 -0.33 5.93e-10 Subjective well-being; LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg10729496 chr3:10149963 C3orf24 -0.54 -7.43 -0.38 9.37e-13 Alzheimer's disease; LUSC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg21782813 chr7:2030301 MAD1L1 0.57 10.31 0.49 7.81e-22 Bipolar disorder and schizophrenia; LUSC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg22532475 chr10:104410764 TRIM8 -0.33 -7.53 -0.38 4.69e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs72634258 0.842 rs6668846 chr1:8152102 C/G cg00042356 chr1:8021962 PARK7 -0.6 -7.62 -0.38 2.69e-13 Inflammatory bowel disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03698729 chr19:2328812 SPPL2B;LSM7 -0.57 -7.47 -0.38 7.16e-13 Bipolar disorder and schizophrenia; LUSC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg18350739 chr11:68623251 NA -0.38 -6.76 -0.35 6.02e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13184539 chr1:241683111 FH 0.43 5.98 0.31 5.64e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs1814175 0.935 rs11040462 chr11:49683158 G/A cg03929089 chr4:120376271 NA -1.0 -18.39 -0.71 1.12e-52 Height; LUSC cis rs2197308 0.549 rs10785517 chr12:38577992 G/T cg13010199 chr12:38710504 ALG10B 0.49 7.23 0.37 3.29e-12 Morning vs. evening chronotype; LUSC cis rs7618501 1.000 rs7374277 chr3:49784777 T/C cg24110177 chr3:50126178 RBM5 0.42 6.7 0.34 8.64e-11 Intelligence (multi-trait analysis); LUSC trans rs4720118 0.967 rs4723288 chr7:33487086 C/T cg23247845 chr10:3679085 NA -0.34 -6.04 -0.31 4.21e-9 Leprosy; LUSC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg13939156 chr17:80058883 NA 0.34 6.59 0.34 1.74e-10 Life satisfaction; LUSC cis rs10887741 0.646 rs11202501 chr10:89437208 C/T cg13926569 chr10:89418898 PAPSS2 0.32 6.92 0.35 2.27e-11 Exercise (leisure time); LUSC cis rs11676348 0.772 rs12471105 chr2:218950209 G/A cg18102446 chr2:218934044 RUFY4 0.36 5.75 0.3 2.06e-8 Ulcerative colitis; LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg08677398 chr8:58056175 NA 0.52 7.2 0.37 4.08e-12 Developmental language disorder (linguistic errors); LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg07703079 chr11:430292 ANO9 0.69 6.97 0.36 1.72e-11 Body mass index; LUSC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg08219700 chr8:58056026 NA 0.46 5.98 0.31 5.71e-9 Developmental language disorder (linguistic errors); LUSC cis rs6546550 0.901 rs34586537 chr2:70163316 G/T cg02498382 chr2:70120550 SNRNP27 0.28 6.86 0.35 3.4e-11 Prevalent atrial fibrillation; LUSC cis rs3859192 0.537 rs12309 chr17:38175462 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.54 0.57 8.07e-30 White blood cell count; LUSC cis rs4891159 0.790 rs56077581 chr18:74116865 T/G cg24786174 chr18:74118243 ZNF516 -0.84 -15.53 -0.65 2.43e-41 Longevity; LUSC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg17279839 chr7:150038598 RARRES2 0.48 7.25 0.37 2.96e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg08975724 chr8:8085496 FLJ10661 -0.48 -7.1 -0.36 7.37e-12 Mood instability; LUSC cis rs7223966 1.000 rs15637 chr17:61772050 C/G cg05941027 chr17:61774174 LIMD2 0.22 5.75 0.3 2e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg19077165 chr18:44547161 KATNAL2 -0.42 -6.31 -0.33 8.87e-10 Personality dimensions; LUSC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.19 0.37 4.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.932 rs449370 chr20:25451180 A/G cg08601574 chr20:25228251 PYGB -0.4 -5.95 -0.31 6.79e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10782582 0.545 rs111927462 chr1:76195422 A/G cg22875332 chr1:76189707 ACADM -0.41 -5.97 -0.31 6.2e-9 Daytime sleep phenotypes; LUSC cis rs7909074 0.966 rs4948645 chr10:45391481 A/G cg04218760 chr10:45406644 TMEM72 -0.28 -6.78 -0.35 5.54e-11 Mean corpuscular volume; LUSC cis rs4919687 0.550 rs10748828 chr10:104456794 C/T cg05855489 chr10:104503620 C10orf26 -0.71 -11.53 -0.53 4.03e-26 Colorectal cancer; LUSC trans rs35110281 0.667 rs4819288 chr21:45120173 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.75 0.51 2.31e-23 Mean corpuscular volume; LUSC cis rs9916302 0.706 rs9893735 chr17:37469858 A/C cg07936489 chr17:37558343 FBXL20 0.78 9.96 0.48 1.27e-20 Glomerular filtration rate (creatinine); LUSC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.51 -0.34 2.78e-10 High light scatter reticulocyte count; LUSC cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg06462663 chr19:18546047 ISYNA1 0.45 7.42 0.38 9.48e-13 Breast cancer; LUSC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg14440974 chr22:39074834 NA 0.39 6.42 0.33 4.58e-10 Menopause (age at onset); LUSC cis rs11098499 0.754 rs938056 chr4:120237453 C/T cg09307838 chr4:120376055 NA 0.7 10.57 0.5 1.04e-22 Corneal astigmatism; LUSC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg03678062 chr6:149772716 ZC3H12D -0.37 -7.49 -0.38 6.32e-13 Dupuytren's disease; LUSC cis rs4478037 1.000 rs4074417 chr3:33161153 A/C cg19404215 chr3:33155277 CRTAP 0.96 9.76 0.47 5.72e-20 Major depressive disorder; LUSC cis rs72781680 1.000 rs72796351 chr2:24158425 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs2637266 0.783 rs846634 chr10:78535323 C/A cg18941641 chr10:78392320 NA 0.4 7.16 0.36 5.14e-12 Pulmonary function; LUSC cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.34e-17 Motion sickness; LUSC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs7911264 0.739 rs7096101 chr10:94362928 G/A cg25093409 chr10:94429542 NA 0.36 6.21 0.32 1.59e-9 Inflammatory bowel disease; LUSC cis rs10782582 0.609 rs6656501 chr1:76266126 A/C cg03433033 chr1:76189801 ACADM -0.42 -6.28 -0.33 1.03e-9 Daytime sleep phenotypes; LUSC cis rs34638657 0.789 rs2303264 chr16:82203711 G/T cg09439754 chr16:82129088 HSD17B2 -0.4 -6.66 -0.34 1.11e-10 Lung adenocarcinoma; LUSC trans rs7586604 0.748 rs6542892 chr2:100382958 A/C cg26466323 chr19:19729535 PBX4 -0.83 -6.0 -0.31 5.1e-9 Cannabis dependence symptom count; LUSC cis rs11190604 0.767 rs35508946 chr10:102191156 A/G cg07080220 chr10:102295463 HIF1AN 0.61 8.15 0.41 7.58e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7577696 0.568 rs410469 chr2:32476992 G/T cg02381751 chr2:32503542 YIPF4 -0.5 -6.67 -0.34 1.06e-10 Inflammatory biomarkers; LUSC cis rs240764 0.604 rs4840153 chr6:101213723 C/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.27 -0.32 1.12e-9 Neuroticism; LUSC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.69 0.63 4.85e-38 Menopause (age at onset); LUSC cis rs34638657 0.872 rs6420435 chr16:82184201 A/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.03 -0.31 4.38e-9 Lung adenocarcinoma; LUSC cis rs2290416 0.786 rs60401352 chr8:144673097 G/A cg14809332 chr8:144654887 C8orf73 0.54 6.53 0.34 2.41e-10 Attention deficit hyperactivity disorder; LUSC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg05347473 chr6:146136440 FBXO30 0.66 11.74 0.54 6.84e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.62 0.43 2.69e-16 Prudent dietary pattern; LUSC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg14004847 chr7:1930337 MAD1L1 -0.54 -8.21 -0.41 4.78e-15 Bipolar disorder and schizophrenia; LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg13531842 chr10:38383804 ZNF37A -0.45 -6.71 -0.34 8.33e-11 Breast cancer; LUSC cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg24692254 chr21:30365293 RNF160 0.92 19.45 0.73 6.89e-57 Dental caries; LUSC cis rs17828380 0.920 rs12903186 chr15:63605364 C/T cg05507819 chr15:63340323 TPM1 -0.75 -6.07 -0.32 3.49e-9 Social communication problems; LUSC cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg01657329 chr11:68192670 LRP5 -0.44 -6.5 -0.34 2.93e-10 Total body bone mineral density; LUSC cis rs6138458 0.743 rs3746330 chr20:24999795 A/G cg06937882 chr20:24974362 C20orf3 -0.32 -5.87 -0.31 1.06e-8 Blood protein levels; LUSC cis rs644799 0.710 rs519511 chr11:95538270 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.51 0.59 1.77e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9399135 0.967 rs4637662 chr6:135298158 T/C cg22676075 chr6:135203613 NA 0.47 7.31 0.37 1.95e-12 Red blood cell count; LUSC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg00310523 chr12:86230176 RASSF9 0.51 9.56 0.46 2.65e-19 Major depressive disorder; LUSC cis rs921665 0.831 rs921666 chr2:3192141 G/C cg02624386 chr2:3182749 NA 0.59 6.61 0.34 1.56e-10 World class endurance athleticism; LUSC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg11843238 chr5:131593191 PDLIM4 -0.39 -6.01 -0.31 4.94e-9 Breast cancer; LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs2282802 0.635 rs270162 chr5:139539090 A/G cg26211634 chr5:139558579 C5orf32 -0.36 -6.71 -0.34 8.52e-11 Intelligence (multi-trait analysis); LUSC cis rs1322512 0.874 rs2623955 chr6:152966375 C/T cg27316956 chr6:152958899 SYNE1 -0.36 -6.24 -0.32 1.33e-9 Tonometry; LUSC trans rs71435601 0.723 rs17041988 chr2:21420697 A/G cg20757404 chr19:378427 NA -0.41 -6.32 -0.33 8.46e-10 Cholesterol, total; LUSC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg13902645 chr11:5959945 NA -0.58 -8.2 -0.41 5.23e-15 DNA methylation (variation); LUSC cis rs28655083 0.529 rs682081 chr16:77103050 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 7.04 0.36 1.12e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs295140 1.000 rs7580924 chr2:201172628 G/C cg04283868 chr2:201171347 SPATS2L 0.44 6.64 0.34 1.29e-10 QT interval; LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg12379764 chr21:47803548 PCNT 0.49 7.0 0.36 1.4e-11 Testicular germ cell tumor; LUSC cis rs7824557 0.628 rs11994376 chr8:11202960 G/A cg21775007 chr8:11205619 TDH 0.81 13.69 0.6 3.69e-34 Retinal vascular caliber; LUSC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg04553112 chr3:125709451 NA -0.49 -5.81 -0.3 1.47e-8 Blood pressure (smoking interaction); LUSC cis rs6445797 0.632 rs4681963 chr3:56687637 C/T cg13792233 chr3:56591045 CCDC66 0.41 5.72 0.3 2.33e-8 Gastritis; LUSC cis rs929354 0.772 rs1182442 chr7:157026633 G/A cg17757837 chr7:157058334 UBE3C -0.82 -13.21 -0.59 2.44e-32 Body mass index; LUSC cis rs11098499 0.908 rs71614449 chr4:120387055 C/T cg24375607 chr4:120327624 NA 0.78 11.55 0.53 3.41e-26 Corneal astigmatism; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg16945982 chr2:25016118 CENPO;C2orf79 -0.49 -6.16 -0.32 2.15e-9 Neuroticism; LUSC cis rs500891 0.574 rs12194258 chr6:84137202 T/C cg08257003 chr6:84140564 ME1 0.37 9.1 0.45 8.48e-18 Platelet-derived growth factor BB levels; LUSC cis rs12594515 1.000 rs11070464 chr15:45984776 C/A cg06207120 chr15:45996521 NA 0.39 6.0 0.31 5.11e-9 Waist circumference;Weight; LUSC cis rs9486719 1.000 rs11756315 chr6:97008678 A/G cg06623918 chr6:96969491 KIAA0776 0.8 10.21 0.49 1.81e-21 Migraine;Coronary artery disease; LUSC cis rs17125944 0.505 rs75194546 chr14:53212069 A/C cg00686598 chr14:53173677 PSMC6 1.15 10.48 0.5 2.05e-22 Alzheimer's disease (late onset); LUSC cis rs709400 0.628 rs1951392 chr14:103853367 T/G cg12935359 chr14:103987150 CKB -0.54 -8.25 -0.41 3.74e-15 Body mass index; LUSC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg05802129 chr4:122689817 NA 0.35 6.22 0.32 1.49e-9 Type 2 diabetes; LUSC cis rs7000551 0.715 rs2461477 chr8:22378314 A/G cg12081754 chr8:22256438 SLC39A14 0.47 7.02 0.36 1.23e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg07332563 chr6:291687 DUSP22 -0.5 -7.65 -0.39 2.18e-13 Menopause (age at onset); LUSC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg16797656 chr11:68205561 LRP5 0.36 6.06 0.31 3.66e-9 Total body bone mineral density; LUSC cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.86 -0.54 2.57e-27 Chronic sinus infection; LUSC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg06028605 chr16:24865363 SLC5A11 0.67 10.58 0.5 9.21e-23 Intelligence (multi-trait analysis); LUSC cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg15423357 chr2:25149977 NA 0.45 9.22 0.45 3.51e-18 Body mass index; LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg00106254 chr7:1943704 MAD1L1 -0.41 -5.94 -0.31 7.06e-9 Bipolar disorder and schizophrenia; LUSC cis rs11190604 1.000 rs2295780 chr10:102305965 A/G cg16342193 chr10:102329863 NA -0.37 -6.45 -0.33 3.9e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11190604 1.000 rs3750629 chr10:102275727 A/G cg07080220 chr10:102295463 HIF1AN 0.67 9.18 0.45 4.45e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7267979 0.933 rs2258728 chr20:25276343 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.33 0.74 2.37e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg23205692 chr1:25664452 TMEM50A -0.43 -6.39 -0.33 5.6e-10 Erythrocyte sedimentation rate; LUSC cis rs11608355 0.545 rs34737994 chr12:109901621 C/T cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs929596 0.556 rs4477910 chr2:234643737 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -9.0 -0.44 1.81e-17 Total bilirubin levels in HIV-1 infection; LUSC cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg12573674 chr2:1569213 NA -0.57 -8.09 -0.4 1.15e-14 IgG glycosylation; LUSC cis rs7168353 0.948 rs10520720 chr15:93634724 A/G cg24217984 chr15:93633278 RGMA -0.38 -6.12 -0.32 2.67e-9 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs738322 1.000 rs133009 chr22:38569653 G/C cg25457927 chr22:38595422 NA -0.42 -8.91 -0.44 3.45e-17 Cutaneous nevi; LUSC cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg23711669 chr6:146136114 FBXO30 0.82 15.02 0.63 2.64e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg04733989 chr22:42467013 NAGA -0.41 -6.64 -0.34 1.24e-10 Cognitive function; LUSC cis rs478304 0.593 rs6591188 chr11:65467953 T/C cg05805236 chr11:65401703 PCNXL3 -0.62 -10.15 -0.49 2.79e-21 Acne (severe); LUSC cis rs2742417 0.609 rs2673066 chr3:45771200 C/T cg10512202 chr3:45649293 LIMD1 0.36 6.01 0.31 4.96e-9 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24158363 chr17:73401717 GRB2 -0.43 -6.05 -0.31 3.97e-9 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg26380479 chr7:97908229 NA -0.28 -6.2 -0.32 1.67e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1865760 0.929 rs1436307 chr6:25939723 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 6.56 0.34 2.07e-10 Height; LUSC cis rs9515201 0.859 rs9521735 chr13:111037328 G/C cg05272587 chr13:111038400 COL4A2 -0.41 -6.92 -0.35 2.27e-11 White matter hyperintensity burden; LUSC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18099408 chr3:52552593 STAB1 -0.43 -7.52 -0.38 5.19e-13 Electroencephalogram traits; LUSC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.62 -0.34 1.4e-10 High light scatter reticulocyte count; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg08200582 chr11:442649 ANO9 -0.57 -6.38 -0.33 5.99e-10 Body mass index; LUSC cis rs881375 0.678 rs1014530 chr9:123685092 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 6.01 0.31 4.83e-9 Rheumatoid arthritis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08943809 chr16:58059531 MMP15 -0.45 -6.02 -0.31 4.48e-9 Bipolar disorder and schizophrenia; LUSC cis rs500891 0.525 rs12697921 chr6:84071913 G/C cg08257003 chr6:84140564 ME1 0.35 8.62 0.43 2.8e-16 Platelet-derived growth factor BB levels; LUSC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs2404602 0.967 rs7167613 chr15:77041192 C/A cg23625390 chr15:77176239 SCAPER 0.55 8.63 0.43 2.54e-16 Blood metabolite levels; LUSC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg00262263 chr6:170184901 NA 0.38 5.86 0.31 1.13e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs1577917 0.666 rs6454471 chr6:86214456 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.49 0.42 6.73e-16 Response to antipsychotic treatment; LUSC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg13939156 chr17:80058883 NA -0.34 -6.76 -0.35 6.08e-11 Life satisfaction; LUSC cis rs12760731 0.623 rs10913551 chr1:178410131 T/G cg00404053 chr1:178313656 RASAL2 0.48 5.76 0.3 1.91e-8 Obesity-related traits; LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg18765753 chr7:1198926 ZFAND2A -0.61 -11.76 -0.54 5.96e-27 Longevity;Endometriosis; LUSC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs11250098 0.574 rs4554431 chr8:10771638 T/A cg21775007 chr8:11205619 TDH -0.49 -6.65 -0.34 1.2e-10 Morning vs. evening chronotype; LUSC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg13175981 chr1:150552382 MCL1 -0.5 -6.66 -0.34 1.14e-10 Tonsillectomy; LUSC cis rs921968 0.565 rs4674329 chr2:219595507 A/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.08 -0.48 4.89e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs7215564 0.818 rs4889776 chr17:78592385 C/T cg23238734 chr17:78661607 RPTOR 0.49 6.18 0.32 1.85e-9 Myopia (pathological); LUSC cis rs2710642 0.927 rs1468748 chr2:63204611 C/T cg17519650 chr2:63277830 OTX1 0.5 6.77 0.35 5.72e-11 LDL cholesterol levels;LDL cholesterol; LUSC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg12311346 chr5:56204834 C5orf35 -0.63 -9.59 -0.46 2.1e-19 Breast cancer;Breast cancer (early onset); LUSC cis rs240764 0.658 rs2132169 chr6:101177663 C/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.12e-9 Neuroticism; LUSC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg21573476 chr21:45109991 RRP1B -0.41 -6.6 -0.34 1.63e-10 Mean corpuscular volume; LUSC cis rs721399 0.539 rs57180587 chr8:18269581 A/T cg18736775 chr8:18248649 NAT2 -0.57 -6.76 -0.35 6.02e-11 Blood metabolite levels; LUSC cis rs1451375 1.000 rs2329341 chr7:50620275 A/C cg18232548 chr7:50535776 DDC 0.5 7.49 0.38 6.04e-13 Malaria; LUSC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg12927641 chr6:109611667 NA -0.37 -6.27 -0.32 1.14e-9 Reticulocyte fraction of red cells; LUSC cis rs9309473 0.607 rs7604588 chr2:73571417 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -7.24 -0.37 3.14e-12 Metabolite levels; LUSC cis rs1559088 0.803 rs10411529 chr19:33616256 A/C cg27124370 chr19:33622961 WDR88 0.55 7.38 0.37 1.3e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg17507749 chr15:85114479 UBE2QP1 0.71 9.24 0.45 3.02e-18 Schizophrenia; LUSC cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg13010199 chr12:38710504 ALG10B 0.7 10.93 0.51 5.81e-24 Bladder cancer; LUSC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg20203395 chr5:56204925 C5orf35 -0.47 -7.03 -0.36 1.16e-11 Breast cancer;Breast cancer (early onset); LUSC trans rs2243480 1.000 rs35058610 chr7:65390925 G/A cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs8014204 0.762 rs7144654 chr14:75298637 A/G cg06637938 chr14:75390232 RPS6KL1 0.51 8.09 0.4 1.15e-14 Caffeine consumption; LUSC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.04 0.31 4.1e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6545883 0.868 rs778755 chr2:61781037 A/G cg15711740 chr2:61764176 XPO1 0.43 6.8 0.35 4.73e-11 Tuberculosis; LUSC trans rs11098499 0.754 rs1546503 chr4:120241167 T/C cg25214090 chr10:38739885 LOC399744 0.46 6.95 0.36 1.94e-11 Corneal astigmatism; LUSC cis rs926938 0.541 rs360623 chr1:115407268 G/C cg12756093 chr1:115239321 AMPD1 0.44 6.42 0.33 4.63e-10 Autism; LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg22903657 chr4:1355424 KIAA1530 -0.36 -5.96 -0.31 6.52e-9 Longevity; LUSC trans rs10838798 0.517 rs1967210 chr11:48096692 G/T cg03929089 chr4:120376271 NA -0.6 -6.11 -0.32 2.78e-9 Height; LUSC trans rs62238980 0.614 rs75691061 chr22:32381222 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg18225595 chr11:63971243 STIP1 0.5 6.18 0.32 1.9e-9 Mean platelet volume; LUSC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg24296786 chr1:45957014 TESK2 0.48 7.31 0.37 2.04e-12 High light scatter reticulocyte count; LUSC cis rs2652834 1.000 rs2729785 chr15:63402574 G/A cg05507819 chr15:63340323 TPM1 0.67 8.16 0.41 7.01e-15 HDL cholesterol; LUSC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg21724239 chr8:58056113 NA 0.61 7.21 0.37 3.7e-12 Developmental language disorder (linguistic errors); LUSC cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg03146154 chr1:46216737 IPP 0.53 7.89 0.4 4.27e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg17971929 chr21:40555470 PSMG1 -0.51 -7.63 -0.39 2.48e-13 Menarche (age at onset); LUSC cis rs4629710 0.592 rs13195700 chr6:131585299 C/T cg12606694 chr6:131520996 AKAP7 0.63 9.61 0.47 1.82e-19 Multiple myeloma (IgH translocation); LUSC cis rs6504663 0.558 rs7627 chr17:48552154 G/C cg03611598 chr17:48586076 MYCBPAP 0.51 6.4 0.33 5.36e-10 Visceral fat; LUSC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg18225595 chr11:63971243 STIP1 0.5 6.17 0.32 2e-9 Mean platelet volume; LUSC cis rs11098499 0.780 rs7680914 chr4:120563053 A/G cg09307838 chr4:120376055 NA 0.73 10.23 0.49 1.47e-21 Corneal astigmatism; LUSC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg16680214 chr1:154839983 KCNN3 -0.52 -9.8 -0.47 4.2e-20 Prostate cancer; LUSC cis rs7312933 0.501 rs7296357 chr12:42729891 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.76 -0.35 6.11e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7719624 1.000 rs1989972 chr5:135377802 A/C cg12897067 chr5:135418308 NA 0.41 5.99 0.31 5.35e-9 Response to cytidine analogues (gemcitabine); LUSC cis rs2762353 0.935 rs11754288 chr6:25776949 G/A cg03517284 chr6:25882590 NA 0.42 7.42 0.38 9.55e-13 Blood metabolite levels; LUSC cis rs73198271 0.531 rs3827812 chr8:8654898 C/T cg01851573 chr8:8652454 MFHAS1 0.67 8.56 0.42 4.13e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9303280 0.901 rs7216389 chr17:38069949 C/T cg10909506 chr17:38081995 ORMDL3 -0.34 -6.24 -0.32 1.33e-9 Self-reported allergy; LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg08088566 chr11:430123 ANO9 0.68 7.56 0.38 3.85e-13 Body mass index; LUSC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg02221750 chr19:17393354 ANKLE1 -0.91 -13.6 -0.6 8.08e-34 Systemic lupus erythematosus; LUSC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg18512352 chr11:47633146 NA -0.47 -9.79 -0.47 4.46e-20 Subjective well-being; LUSC cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.43 -7.99 -0.4 2.21e-14 Monocyte percentage of white cells; LUSC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg22968622 chr17:43663579 NA -0.78 -11.93 -0.55 1.4e-27 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg14552801 chr7:65878734 NA -0.39 -6.02 -0.31 4.6e-9 Aortic root size; LUSC cis rs9443645 0.527 rs12527806 chr6:79507667 A/T cg05283184 chr6:79620031 NA -0.45 -8.33 -0.41 2.18e-15 Intelligence (multi-trait analysis); LUSC cis rs2742417 0.603 rs2742372 chr3:45783472 T/C cg04837898 chr3:45731254 SACM1L -0.46 -7.46 -0.38 7.62e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg23422044 chr7:1970798 MAD1L1 -0.6 -6.32 -0.33 8.52e-10 Bipolar disorder; LUSC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg07741184 chr6:167504864 NA 0.4 7.13 0.36 6.36e-12 Crohn's disease; LUSC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12893668 0.667 rs11844466 chr14:104066422 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -6.38 -0.33 5.92e-10 Reticulocyte count; LUSC cis rs6736093 0.966 rs11682629 chr2:112744299 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -6.03 -0.31 4.39e-9 Coronary artery disease; LUSC cis rs2200578 0.841 rs111592987 chr2:99601250 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.55 6.66 0.34 1.1e-10 IgG glycosylation; LUSC cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg01256987 chr12:42539512 GXYLT1 -0.46 -8.81 -0.43 6.81e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs79976124 0.879 rs10944856 chr6:66636960 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 8.73 0.43 1.28e-16 Type 2 diabetes; LUSC cis rs6901004 0.570 rs783084 chr6:111477887 T/C cg15721981 chr6:111408429 SLC16A10 0.59 7.89 0.4 4.47e-14 Blood metabolite levels; LUSC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.06 -0.36 9.65e-12 Lung cancer; LUSC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg04842962 chr6:43655489 MRPS18A -1.06 -23.4 -0.79 2.34e-72 IgG glycosylation; LUSC cis rs7607369 0.536 rs6436092 chr2:219669148 T/A cg02176678 chr2:219576539 TTLL4 -0.52 -9.15 -0.45 5.72e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs9486719 0.895 rs4486019 chr6:96883814 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs16976116 0.901 rs7172108 chr15:55501551 C/G cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4595586 0.566 rs11615585 chr12:39409351 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.16 0.32 2.05e-9 Morning vs. evening chronotype; LUSC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg22920501 chr2:26401640 FAM59B 0.7 9.18 0.45 4.53e-18 Gut microbiome composition (summer); LUSC cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.49 0.42 6.76e-16 Motion sickness; LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg00166722 chr3:10149974 C3orf24 0.56 7.54 0.38 4.61e-13 Alzheimer's disease; LUSC cis rs12681287 0.605 rs2953509 chr8:87343194 C/T cg27223183 chr8:87520930 FAM82B -0.54 -7.1 -0.36 7.54e-12 Caudate activity during reward; LUSC cis rs11098499 0.954 rs10031665 chr4:120422852 T/C cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg26855724 chr1:75198818 TYW3;CRYZ 0.48 7.57 0.38 3.6e-13 Resistin levels; LUSC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.6 0.47 1.95e-19 Bipolar disorder; LUSC cis rs6542838 0.611 rs1878589 chr2:99517979 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.03 -0.31 4.3e-9 Fear of minor pain; LUSC cis rs6430585 0.591 rs12466487 chr2:136407078 C/T cg07169764 chr2:136633963 MCM6 -1.06 -13.41 -0.59 4.34e-33 Corneal structure; LUSC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1524927 0.966 rs7788744 chr7:96358649 T/A cg03808172 chr7:96339361 SHFM1 0.43 6.53 0.34 2.45e-10 Total body bone mineral density; LUSC cis rs7122539 0.646 rs682842 chr11:66568943 A/G cg24851651 chr11:66362959 CCS -0.54 -9.89 -0.48 2.07e-20 HIV-1 susceptibility; LUSC cis rs708547 0.874 rs1718869 chr4:57880232 A/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 9.02 0.44 1.52e-17 Response to bleomycin (chromatid breaks); LUSC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg18230493 chr5:56204884 C5orf35 -0.88 -13.39 -0.59 4.99e-33 Initial pursuit acceleration; LUSC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg05347473 chr6:146136440 FBXO30 0.59 9.69 0.47 9.97e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg03806693 chr22:41940476 POLR3H 0.99 14.18 0.61 4.51e-36 Cannabis dependence symptom count; LUSC cis rs929354 0.713 rs10085650 chr7:156993413 T/C cg17757837 chr7:157058334 UBE3C 0.82 12.99 0.58 1.6e-31 Body mass index; LUSC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.46 -7.94 -0.4 3.14e-14 Total body bone mineral density; LUSC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg07636037 chr3:49044803 WDR6 1.03 17.66 0.69 9.24e-50 Parkinson's disease; LUSC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.67 0.34 1.05e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs614226 0.935 rs588132 chr12:121024066 A/G cg21053147 chr12:120880522 NA -0.48 -5.81 -0.3 1.46e-8 Type 1 diabetes nephropathy; LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg16362232 chr11:430036 ANO9 0.62 8.11 0.41 9.85e-15 Body mass index; LUSC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg04546413 chr19:29218101 NA 0.71 11.0 0.52 3.19e-24 Methadone dose in opioid dependence; LUSC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.62 0.34 1.46e-10 Intelligence (multi-trait analysis); LUSC cis rs7808935 0.628 rs62451116 chr7:27938980 A/G cg22168087 chr7:27702803 HIBADH 0.7 8.17 0.41 6.56e-15 Prostate cancer; LUSC cis rs1372520 0.684 rs1442144 chr4:90736113 T/C cg01966878 chr4:90757139 SNCA -0.42 -5.99 -0.31 5.43e-9 Neuroticism; LUSC trans rs9926296 0.744 rs164749 chr16:89708224 A/C cg13990129 chr9:108311111 FSD1L -0.39 -6.59 -0.34 1.67e-10 Vitiligo; LUSC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg22800045 chr5:56110881 MAP3K1 0.76 9.72 0.47 7.77e-20 Initial pursuit acceleration; LUSC cis rs7824557 1.000 rs7824557 chr8:11104111 C/T cg21775007 chr8:11205619 TDH -0.52 -7.91 -0.4 3.91e-14 Retinal vascular caliber; LUSC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg15445000 chr17:37608096 MED1 0.38 6.49 0.33 3.1e-10 Glomerular filtration rate (creatinine); LUSC cis rs939658 1.000 rs12439908 chr15:79456381 T/C cg17916960 chr15:79447300 NA 0.47 9.51 0.46 3.94e-19 Refractive error; LUSC cis rs4077515 0.839 rs3812563 chr9:139271106 A/G cg14169450 chr9:139327907 INPP5E 0.42 7.56 0.38 3.97e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs2413583 0.591 rs17000981 chr22:39708017 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.62 6.31 0.33 8.86e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs17608059 0.679 rs9898056 chr17:13951966 C/G cg27005118 chr17:13972210 COX10 -0.46 -8.68 -0.43 1.72e-16 Temperament; LUSC cis rs9287719 0.839 rs11683335 chr2:10756665 C/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2228479 0.541 rs62052173 chr16:89950739 T/C cg04013166 chr16:89971882 TCF25 0.62 7.24 0.37 3.1e-12 Skin colour saturation; LUSC cis rs9303401 0.659 rs7210700 chr17:56668186 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC cis rs3126085 0.935 rs4845736 chr1:152175551 G/A cg03465714 chr1:152285911 FLG -0.4 -5.69 -0.3 2.82e-8 Atopic dermatitis; LUSC cis rs9311676 0.656 rs55727087 chr3:58404547 G/A cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs9807841 0.592 rs2742313 chr19:10799750 T/C cg09936142 chr19:10668400 KRI1 -0.4 -6.4 -0.33 5.32e-10 Inflammatory skin disease; LUSC cis rs2354432 0.607 rs7516430 chr1:146767062 A/G cg25205988 chr1:146714368 CHD1L -1.02 -10.76 -0.51 2.28e-23 Mitochondrial DNA levels; LUSC cis rs939658 0.805 rs11634679 chr15:79432475 T/C cg17916960 chr15:79447300 NA -0.53 -10.49 -0.5 1.93e-22 Refractive error; LUSC cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg24642439 chr20:33292090 TP53INP2 0.53 8.14 0.41 8.14e-15 Coronary artery disease; LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg08470875 chr2:26401718 FAM59B 0.7 9.09 0.45 8.81e-18 Gut microbiome composition (summer); LUSC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg24977027 chr2:88469347 THNSL2 0.56 5.84 0.3 1.21e-8 Plasma clusterin levels; LUSC cis rs7586879 0.789 rs17046737 chr2:25127835 C/T cg01884057 chr2:25150051 NA 0.42 8.82 0.43 6.24e-17 Body mass index; LUSC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg02423579 chr7:2872169 GNA12 -0.37 -5.73 -0.3 2.24e-8 Height; LUSC cis rs34779708 0.931 rs7079498 chr10:35375344 C/T cg03585969 chr10:35415529 CREM 0.62 9.23 0.45 3.12e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3087591 1.000 rs7220483 chr17:29577248 G/A cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.15 -0.41 7.29e-15 Hip circumference; LUSC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg21028142 chr17:79581711 NPLOC4 -0.33 -7.75 -0.39 1.09e-13 Eye color traits; LUSC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg17264618 chr3:40429014 ENTPD3 0.34 7.25 0.37 2.94e-12 Renal cell carcinoma; LUSC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg05855489 chr10:104503620 C10orf26 -0.7 -10.32 -0.49 7.49e-22 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg00106254 chr7:1943704 MAD1L1 -0.39 -5.68 -0.3 2.88e-8 Bipolar disorder and schizophrenia; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg09177884 chr7:1199841 ZFAND2A -0.48 -6.52 -0.34 2.59e-10 Longevity;Endometriosis; LUSC cis rs7223966 1.000 rs992416 chr17:61745905 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.74 0.35 6.99e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg14983838 chr19:29218262 NA 0.65 9.18 0.45 4.46e-18 Methadone dose in opioid dependence; LUSC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg22823121 chr1:150693482 HORMAD1 -0.52 -7.54 -0.38 4.62e-13 Melanoma; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg22166914 chr1:53195759 ZYG11B 0.46 7.62 0.38 2.64e-13 Monocyte count; LUSC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.49 9.02 0.44 1.56e-17 Total body bone mineral density; LUSC cis rs921968 0.643 rs2556384 chr2:219532903 C/T cg02176678 chr2:219576539 TTLL4 -0.58 -10.42 -0.5 3.41e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs1580019 1.000 rs1580019 chr7:32493169 A/T cg06627557 chr7:32535165 LSM5;AVL9 -0.81 -12.4 -0.56 2.7e-29 Cognitive ability; LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg25072359 chr17:41440525 NA 0.66 9.43 0.46 7.13e-19 Menopause (age at onset); LUSC cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg01256987 chr12:42539512 GXYLT1 -0.47 -8.99 -0.44 1.83e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg09044154 chr16:88155775 NA -0.56 -7.56 -0.38 3.96e-13 Menopause (age at onset); LUSC cis rs9902453 0.740 rs1382391 chr17:28111986 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.69 -0.54 1.07e-26 Coffee consumption (cups per day); LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg08132940 chr7:1081526 C7orf50 -0.52 -6.25 -0.32 1.25e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2274273 0.673 rs2209808 chr14:55807695 A/T cg04306507 chr14:55594613 LGALS3 0.53 11.32 0.53 2.4e-25 Protein biomarker; LUSC cis rs2729354 0.953 rs2649663 chr11:57357305 C/T cg24343310 chr11:57249947 NA 0.35 6.45 0.33 4e-10 Blood protein levels; LUSC cis rs6546537 1.000 rs4286306 chr2:69885647 G/C cg10773587 chr2:69614142 GFPT1 -0.47 -7.37 -0.37 1.37e-12 Serum thyroid-stimulating hormone levels; LUSC trans rs61931739 0.534 rs7965503 chr12:34199349 A/G cg26384229 chr12:38710491 ALG10B 0.74 11.96 0.55 1.15e-27 Morning vs. evening chronotype; LUSC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg06481639 chr22:41940642 POLR3H -0.51 -6.13 -0.32 2.41e-9 Vitiligo; LUSC cis rs3857536 0.776 rs9363560 chr6:66949686 T/G cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs2243480 0.522 rs73150635 chr7:65972490 C/T cg07424592 chr7:64974309 NA 1.07 6.61 0.34 1.53e-10 Diabetic kidney disease; LUSC cis rs72781680 0.821 rs72796401 chr2:24180078 T/A cg08917208 chr2:24149416 ATAD2B 0.61 6.96 0.36 1.82e-11 Lymphocyte counts; LUSC trans rs7681440 0.838 rs1348224 chr4:90761946 G/A cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.0 -0.31 5.12e-9 Dementia with Lewy bodies; LUSC cis rs62400317 0.859 rs11964690 chr6:45258068 A/G cg20913747 chr6:44695427 NA -0.47 -7.6 -0.38 2.96e-13 Total body bone mineral density; LUSC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg27170947 chr2:26402098 FAM59B -0.64 -9.37 -0.46 1.1e-18 Gut microbiome composition (summer); LUSC cis rs7937682 0.889 rs12360825 chr11:111528786 A/T cg22437258 chr11:111473054 SIK2 0.48 6.44 0.33 4.18e-10 Primary sclerosing cholangitis; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01684318 chr3:183415696 YEATS2 0.35 5.96 0.31 6.24e-9 Asthma; LUSC trans rs853679 0.607 rs61742093 chr6:27879982 A/G cg06606381 chr12:133084897 FBRSL1 -0.99 -8.56 -0.42 4.08e-16 Depression; LUSC cis rs4363385 0.747 rs1055935 chr1:152975941 C/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.71 -0.39 1.44e-13 Inflammatory skin disease; LUSC cis rs1865760 0.929 rs9358896 chr6:25943197 C/A cg16482183 chr6:26056742 HIST1H1C 0.47 6.72 0.34 7.98e-11 Height; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg16132339 chr22:24313637 DDTL;DDT 0.41 6.47 0.33 3.41e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.58 12.79 0.57 9.32e-31 Tonsillectomy; LUSC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs11809207 0.953 rs17163666 chr1:26525383 A/G cg00147160 chr1:26503991 CNKSR1 0.41 6.85 0.35 3.52e-11 Height; LUSC cis rs10911232 0.507 rs4652765 chr1:182994147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.12e-24 Hypertriglyceridemia; LUSC cis rs8141529 0.711 rs5752797 chr22:29179998 C/T cg02153584 chr22:29168773 CCDC117 0.51 6.71 0.34 8.23e-11 Lymphocyte counts; LUSC cis rs11785400 1.000 rs4736342 chr8:143735190 A/G cg24634471 chr8:143751801 JRK 0.59 8.97 0.44 2.12e-17 Schizophrenia; LUSC trans rs514406 0.505 rs835609 chr1:53170494 T/C cg24643429 chr1:3562429 WDR8 0.33 5.94 0.31 7.03e-9 Monocyte count; LUSC cis rs478304 0.934 rs1193692 chr11:65504069 A/C cg08755490 chr11:65554678 OVOL1 0.41 5.84 0.3 1.21e-8 Acne (severe); LUSC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg00049323 chr5:472564 LOC25845 -0.41 -6.05 -0.31 3.87e-9 Cystic fibrosis severity; LUSC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg06808227 chr14:105710500 BRF1 -0.66 -10.08 -0.48 4.97e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg22823121 chr1:150693482 HORMAD1 0.53 7.91 0.4 3.84e-14 Melanoma; LUSC cis rs3743266 0.613 rs1869485 chr15:60746605 G/A cg21667061 chr15:60772094 NARG2 -0.38 -6.41 -0.33 4.94e-10 Menarche (age at onset); LUSC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg03609598 chr5:56110824 MAP3K1 -0.41 -6.09 -0.32 3.02e-9 Initial pursuit acceleration; LUSC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg18827107 chr12:86230957 RASSF9 -0.45 -6.73 -0.35 7.51e-11 Major depressive disorder; LUSC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg13206674 chr6:150067644 NUP43 0.59 9.28 0.45 2.26e-18 Lung cancer; LUSC trans rs4718428 0.924 rs6971897 chr7:66412774 T/A cg18876405 chr7:65276391 NA 0.45 7.06 0.36 9.62e-12 Corneal structure; LUSC cis rs7677751 0.806 rs7673027 chr4:55096180 T/A cg17187183 chr4:55093834 PDGFRA 0.39 5.89 0.31 9.61e-9 Corneal astigmatism; LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg23758822 chr17:41437982 NA 1.05 20.05 0.74 2.97e-59 Menopause (age at onset); LUSC cis rs61861422 0.516 rs12412216 chr10:134393338 C/T cg27286337 chr10:134555280 INPP5A 0.53 5.69 0.3 2.83e-8 Primary sclerosing cholangitis; LUSC cis rs4843747 0.671 rs28451517 chr16:88109127 A/C cg09044154 chr16:88155775 NA -0.55 -7.32 -0.37 1.88e-12 Menopause (age at onset); LUSC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.7 -0.34 9.03e-11 Mean platelet volume; LUSC trans rs7824557 0.564 rs34389419 chr8:11229319 C/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.3 -0.41 2.59e-15 Retinal vascular caliber; LUSC cis rs7212938 0.509 rs62068170 chr17:38103210 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.49 -8.17 -0.41 6.23e-15 Asthma and hay fever; LUSC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.76 -13.97 -0.61 2.97e-35 Intelligence (multi-trait analysis); LUSC cis rs6060717 0.536 rs8125393 chr20:34496162 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.67 -0.3 3.14e-8 Hip circumference adjusted for BMI; LUSC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg22681709 chr2:178499509 PDE11A -0.47 -8.72 -0.43 1.37e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs897984 0.683 rs72799316 chr16:30827205 A/G cg00531865 chr16:30841666 NA -0.34 -6.2 -0.32 1.65e-9 Dementia with Lewy bodies; LUSC cis rs7640424 0.589 rs78673584 chr3:107813133 A/G cg09227934 chr3:107805635 CD47 -0.55 -7.86 -0.4 5.26e-14 Body mass index; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg03352830 chr11:487213 PTDSS2 0.77 9.18 0.45 4.71e-18 Body mass index; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg16606324 chr3:10149918 C3orf24 0.58 8.18 0.41 5.99e-15 Alzheimer's disease; LUSC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg08499158 chr17:42289980 UBTF -0.52 -8.58 -0.42 3.63e-16 Total body bone mineral density; LUSC cis rs1595825 0.945 rs2139050 chr2:198852636 A/G cg00982548 chr2:198649783 BOLL -0.56 -7.01 -0.36 1.33e-11 Ulcerative colitis; LUSC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.87 -0.35 3.2e-11 Lung cancer; LUSC cis rs3740540 0.507 rs10794161 chr10:126291327 C/A cg04949429 chr10:126290192 LHPP 0.36 7.56 0.38 3.95e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC trans rs800082 1.000 rs1405599 chr3:144328759 T/C cg24215973 chr2:240111563 HDAC4 -0.45 -6.91 -0.35 2.49e-11 Smoking behavior; LUSC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg26441486 chr22:50317300 CRELD2 -0.45 -7.43 -0.38 9.42e-13 Schizophrenia; LUSC cis rs9733 0.744 rs4970976 chr1:150779524 T/A cg13175981 chr1:150552382 MCL1 0.43 6.09 0.32 3.16e-9 Tonsillectomy; LUSC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg22903471 chr2:27725779 GCKR 0.41 6.95 0.36 1.91e-11 Total body bone mineral density; LUSC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg03909863 chr11:638404 DRD4 -0.39 -5.89 -0.31 9.34e-9 Systemic lupus erythematosus; LUSC cis rs637571 0.544 rs56239996 chr11:65730003 A/T cg26695010 chr11:65641043 EFEMP2 -0.48 -6.96 -0.36 1.85e-11 Eosinophil percentage of white cells; LUSC cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg17063962 chr7:91808500 NA -0.59 -9.28 -0.45 2.13e-18 Breast cancer; LUSC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg06505273 chr16:24850292 NA -0.38 -5.98 -0.31 5.89e-9 Intelligence (multi-trait analysis); LUSC cis rs67072384 1.000 rs12292781 chr11:72448385 A/C cg04827223 chr11:72435913 ARAP1 -0.82 -7.65 -0.39 2.12e-13 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs453301 0.653 rs7005133 chr8:8901222 T/G cg21775007 chr8:11205619 TDH 0.43 6.05 0.31 3.96e-9 Joint mobility (Beighton score); LUSC cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.83 -0.35 4.05e-11 Monocyte percentage of white cells; LUSC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg17507749 chr15:85114479 UBE2QP1 0.69 8.71 0.43 1.38e-16 Schizophrenia; LUSC cis rs1564271 0.961 rs2927921 chr10:27016001 A/C cg13837822 chr10:26931731 LOC731789 0.44 8.85 0.44 5.32e-17 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs7178572 1.000 rs11633054 chr15:77747276 A/G cg22256960 chr15:77711686 NA -0.52 -8.74 -0.43 1.12e-16 Type 2 diabetes; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.98 0.4 2.35e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7789940 0.810 rs12533978 chr7:75943352 T/C cg10167463 chr7:75959203 YWHAG -0.63 -9.32 -0.45 1.61e-18 Multiple sclerosis; LUSC cis rs6835098 0.962 rs3733477 chr4:174090004 G/A cg08422745 chr4:174089978 GALNT7 -0.84 -13.7 -0.6 3.2e-34 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.94 -0.36 2.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg05347473 chr6:146136440 FBXO30 0.58 10.1 0.48 4.16e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg04727924 chr7:799746 HEATR2 -0.57 -6.06 -0.31 3.75e-9 Cerebrospinal P-tau181p levels; LUSC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg24690094 chr11:67383802 NA 0.42 8.13 0.41 8.26e-15 Mean corpuscular volume; LUSC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg13683864 chr3:40499215 RPL14 -1.12 -21.22 -0.76 7.32e-64 Renal cell carcinoma; LUSC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg05872129 chr22:39784769 NA -0.62 -11.66 -0.54 1.36e-26 Intelligence (multi-trait analysis); LUSC cis rs6754311 0.681 rs4954493 chr2:136609975 T/C cg07169764 chr2:136633963 MCM6 -0.62 -8.24 -0.41 4.08e-15 Mosquito bite size; LUSC cis rs477692 0.604 rs1008982 chr10:131445731 T/C cg05714579 chr10:131428358 MGMT -0.7 -10.81 -0.51 1.46e-23 Response to temozolomide; LUSC trans rs7824557 0.628 rs11991153 chr8:11203107 A/T cg08975724 chr8:8085496 FLJ10661 0.43 6.26 0.32 1.22e-9 Retinal vascular caliber; LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.34 5.81 0.3 1.49e-8 Menopause (age at onset); LUSC cis rs10465746 0.658 rs980418 chr1:84365653 T/G cg10977910 chr1:84465055 TTLL7 0.51 7.29 0.37 2.21e-12 Obesity-related traits; LUSC cis rs7608623 0.804 rs11675585 chr2:24237180 T/C cg08917208 chr2:24149416 ATAD2B -0.44 -5.85 -0.3 1.19e-8 Obesity-related traits; LUSC cis rs9796 0.870 rs8042088 chr15:41337487 C/T cg18705301 chr15:41695430 NDUFAF1 0.42 7.32 0.37 1.81e-12 Menopause (age at onset); LUSC cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg24450063 chr1:156163899 SLC25A44 1.04 16.9 0.68 1.01e-46 Testicular germ cell tumor; LUSC cis rs4654899 1.000 rs6703227 chr1:21374810 A/G cg01072550 chr1:21505969 NA -0.56 -8.38 -0.42 1.48e-15 Superior frontal gyrus grey matter volume; LUSC cis rs8025790 0.508 rs4776943 chr15:67836069 T/C cg05925327 chr15:68127851 NA -0.4 -6.16 -0.32 2.13e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs3106136 1.000 rs3106136 chr4:95153349 T/C cg11021082 chr4:95130006 SMARCAD1 -0.34 -5.92 -0.31 7.99e-9 Capecitabine sensitivity; LUSC cis rs701145 0.824 rs355767 chr3:154045895 G/A cg17054900 chr3:154042577 DHX36 0.81 8.73 0.43 1.21e-16 Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13582782 chr10:27793181 RAB18 0.43 6.08 0.32 3.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6502050 0.799 rs8082355 chr17:80120316 A/G cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs453301 0.592 rs4841084 chr8:8883905 C/T cg06636001 chr8:8085503 FLJ10661 0.63 9.74 0.47 6.64e-20 Joint mobility (Beighton score); LUSC cis rs7512552 0.839 rs1260459 chr1:150348253 T/G cg15654264 chr1:150340011 RPRD2 0.62 10.29 0.49 9.57e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.89 0.31 9.57e-9 Menopause (age at onset); LUSC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg26597838 chr10:835615 NA 0.74 9.26 0.45 2.62e-18 Eosinophil percentage of granulocytes; LUSC cis rs5758511 0.680 rs5758657 chr22:42618669 A/G cg12850546 chr22:42539477 CYP2D7P1 -0.47 -5.83 -0.3 1.31e-8 Birth weight; LUSC cis rs1904096 0.506 rs6823404 chr4:95197520 C/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.44 -0.42 9.73e-16 Type 2 diabetes; LUSC cis rs10905065 0.895 rs3736462 chr10:5804455 A/G cg11519256 chr10:5708881 ASB13 0.4 5.8 0.3 1.51e-8 Menopause (age at onset); LUSC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs3892630 0.620 rs10413279 chr19:33182746 A/G cg22980127 chr19:33182716 NUDT19 0.97 15.11 0.64 1.08e-39 Red blood cell traits; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg17541715 chr7:1216824 NA -0.39 -6.18 -0.32 1.89e-9 Longevity;Endometriosis; LUSC cis rs7712401 0.601 rs144597 chr5:122223232 A/C cg19077854 chr5:122220652 SNX24 0.4 8.85 0.44 5.36e-17 Mean platelet volume; LUSC trans rs488628 1.000 rs517313 chr3:118134320 T/C cg06621744 chr14:37052470 NKX2-8 -0.29 -6.47 -0.33 3.56e-10 White matter integrity (bipolar disorder risk interaction); LUSC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg24675056 chr1:15929824 NA 0.48 8.17 0.41 6.51e-15 Systolic blood pressure; LUSC cis rs1981331 1.000 rs77587985 chr21:47993897 A/G cg17243659 chr21:48055224 PRMT2 0.86 6.24 0.32 1.31e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg13560548 chr3:10150139 C3orf24 0.48 6.75 0.35 6.63e-11 Alzheimer's disease; LUSC trans rs11098499 0.754 rs66900435 chr4:120249425 C/A cg25214090 chr10:38739885 LOC399744 0.43 6.46 0.33 3.61e-10 Corneal astigmatism; LUSC cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg20302533 chr7:39170763 POU6F2 0.52 8.18 0.41 6.03e-15 IgG glycosylation; LUSC cis rs6693567 0.545 rs7411534 chr1:150447269 C/T cg09579323 chr1:150459698 TARS2 0.4 5.7 0.3 2.59e-8 Migraine; LUSC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg07061783 chr6:25882402 NA -0.45 -6.43 -0.33 4.45e-10 Blood metabolite levels; LUSC trans rs3010562 1.000 rs3010562 chr6:167765251 A/G cg13679164 chr6:161258479 NA -0.44 -6.58 -0.34 1.77e-10 Gut microbiome composition (summer and winter); LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.24 0.52 4.35e-25 Menopause (age at onset); LUSC cis rs4776059 0.958 rs933860 chr15:52965468 T/C cg22715398 chr15:52968154 KIAA1370 -0.67 -9.27 -0.45 2.33e-18 Schizophrenia; LUSC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg06484146 chr7:12443880 VWDE -0.68 -7.23 -0.37 3.41e-12 Coronary artery disease; LUSC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg04346459 chr6:41068666 NFYA;LOC221442 0.55 8.46 0.42 8.61e-16 Alzheimer's disease (late onset); LUSC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg18876405 chr7:65276391 NA -0.69 -12.3 -0.56 6.25e-29 Aortic root size; LUSC cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg23711669 chr6:146136114 FBXO30 0.88 16.22 0.66 4.99e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs12979813 1.000 rs12979813 chr19:11342703 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 -0.39 -5.74 -0.3 2.1e-8 HDL cholesterol; LUSC cis rs3105593 0.575 rs4318151 chr15:50729274 A/G cg08437265 chr15:50716283 USP8 0.45 6.53 0.34 2.38e-10 QT interval; LUSC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg07636037 chr3:49044803 WDR6 0.44 6.49 0.33 3.04e-10 Resting heart rate; LUSC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg19077165 chr18:44547161 KATNAL2 0.43 6.51 0.34 2.72e-10 Personality dimensions; LUSC cis rs6732160 0.691 rs13402225 chr2:73416906 T/G cg24220031 chr2:73402428 NA -0.23 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.8 -0.35 4.89e-11 Developmental language disorder (linguistic errors); LUSC cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg27165867 chr14:105738592 BRF1 -0.51 -7.5 -0.38 5.75e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs1348850 0.668 rs13010396 chr2:178492934 T/C cg22681709 chr2:178499509 PDE11A -0.45 -7.47 -0.38 7.03e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6495367 1.000 rs745030 chr15:79381705 G/A cg17916960 chr15:79447300 NA 0.35 6.6 0.34 1.64e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2730245 0.527 rs842700 chr7:158697565 G/A cg24397884 chr7:158709396 WDR60 0.77 8.64 0.43 2.39e-16 Height; LUSC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.34 6.91 0.35 2.51e-11 Schizophrenia; LUSC cis rs3008870 1.000 rs2755248 chr1:67492624 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.96 15.44 0.65 6e-41 Lymphocyte percentage of white cells; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11688874 chr10:28822482 WAC 0.46 6.8 0.35 4.79e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04746670 chr2:122288182 CLASP1;RNU4ATAC -0.4 -6.06 -0.31 3.74e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs977987 0.800 rs3784935 chr16:75336430 T/G cg03315344 chr16:75512273 CHST6 0.48 8.9 0.44 3.61e-17 Dupuytren's disease; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.42 0.53 9.8e-26 Prudent dietary pattern; LUSC cis rs79349575 0.749 rs957557 chr17:47003221 G/T cg22482690 chr17:47019901 SNF8 0.39 7.38 0.37 1.3e-12 Type 2 diabetes; LUSC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg27539214 chr16:67997921 SLC12A4 -0.58 -7.74 -0.39 1.23e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg09509183 chr1:209979624 IRF6 0.53 5.71 0.3 2.46e-8 Coronary artery disease; LUSC cis rs240764 0.555 rs11967951 chr6:101231905 G/A cg09795085 chr6:101329169 ASCC3 0.44 6.25 0.32 1.24e-9 Neuroticism; LUSC cis rs1008375 1.000 rs7671752 chr4:17661398 C/T cg16339924 chr4:17578868 LAP3 0.55 8.21 0.41 4.77e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9359856 0.564 rs61739327 chr6:90340446 C/T cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.41 -0.42 1.19e-15 Bipolar disorder; LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg00149659 chr3:10157352 C3orf10 -0.87 -11.59 -0.54 2.51e-26 Alzheimer's disease; LUSC cis rs7267979 0.966 rs6037097 chr20:25347221 C/T cg08601574 chr20:25228251 PYGB 0.42 6.56 0.34 2.05e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs854765 0.647 rs6502637 chr17:17986098 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.66 10.85 0.51 1.1e-23 Total body bone mineral density; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13731338 chr3:128145454 NA 0.72 6.05 0.31 3.96e-9 Cognitive performance; LUSC cis rs4969178 0.965 rs8077859 chr17:76386335 C/T cg20026190 chr17:76395443 PGS1 0.44 7.72 0.39 1.32e-13 HDL cholesterol levels; LUSC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg06671706 chr8:8559999 CLDN23 0.43 5.87 0.31 1.07e-8 Obesity-related traits; LUSC cis rs6736093 0.966 rs11686647 chr2:112684397 T/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.9 -0.31 8.73e-9 Coronary artery disease; LUSC trans rs9291683 0.588 rs34501273 chr4:9996996 C/T cg26043149 chr18:55253948 FECH 0.46 6.59 0.34 1.75e-10 Bone mineral density; LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg15790184 chr11:494944 RNH1 0.5 5.7 0.3 2.67e-8 Body mass index; LUSC cis rs16917546 1.000 rs7094595 chr10:64415413 T/A cg03961010 chr10:64397487 ZNF365 -0.41 -6.49 -0.33 3.1e-10 Basal cell carcinoma; LUSC trans rs1147199 0.585 rs7468983 chr9:87247277 C/T cg18287975 chr5:88178977 MEF2C -0.7 -6.02 -0.31 4.56e-9 Body mass index; LUSC cis rs1577917 0.655 rs12203963 chr6:86223316 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 6.97 0.36 1.74e-11 Response to antipsychotic treatment; LUSC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg02551604 chr5:131831745 NA 0.46 7.15 0.36 5.38e-12 Asthma (sex interaction); LUSC cis rs11608355 0.545 rs4766604 chr12:109892179 T/C cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs459571 0.959 rs465724 chr9:136910097 C/T cg13789015 chr9:136890014 NCRNA00094 0.62 11.09 0.52 1.49e-24 Platelet distribution width; LUSC cis rs950169 0.580 rs35516100 chr15:85195430 C/T cg11189052 chr15:85197271 WDR73 0.49 6.19 0.32 1.79e-9 Schizophrenia; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26468274 chr6:43544000 XPO5;POLH 0.42 6.09 0.32 3.08e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7819412 0.745 rs4841498 chr8:10985432 C/T cg21775007 chr8:11205619 TDH -0.51 -7.55 -0.38 4.24e-13 Triglycerides; LUSC cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg21535247 chr6:8435926 SLC35B3 0.57 8.67 0.43 1.96e-16 Motion sickness; LUSC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.65e-13 Bipolar disorder; LUSC cis rs7666738 0.712 rs11731393 chr4:98859070 G/C cg17366294 chr4:99064904 C4orf37 0.52 7.32 0.37 1.92e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7512552 0.839 rs834229 chr1:150384665 G/C cg15654264 chr1:150340011 RPRD2 0.66 11.01 0.52 2.84e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg05368731 chr17:41323189 NBR1 0.92 15.57 0.65 1.75e-41 Menopause (age at onset); LUSC cis rs3796619 1.000 rs13146371 chr4:1082887 C/T cg27284194 chr4:1044797 NA 0.48 7.85 0.39 5.73e-14 Recombination rate (males); LUSC cis rs1568889 0.938 rs1464898 chr11:28034748 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.44 0.46 6.65e-19 Bipolar disorder; LUSC cis rs4919694 1.000 rs111622998 chr10:104953021 C/A cg04362960 chr10:104952993 NT5C2 1.21 14.43 0.62 4.84e-37 Arsenic metabolism; LUSC cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg17652424 chr22:38574118 PLA2G6 -0.31 -6.79 -0.35 4.99e-11 Cutaneous nevi; LUSC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg12292205 chr6:26970375 C6orf41 -0.67 -11.61 -0.54 2e-26 Autism spectrum disorder or schizophrenia; LUSC cis rs1568889 0.774 rs11030235 chr11:28212375 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 12.69 0.57 2.12e-30 Bipolar disorder; LUSC cis rs231513 0.911 rs124721 chr17:41959808 T/C cg26893861 chr17:41843967 DUSP3 -0.53 -5.84 -0.3 1.26e-8 Cognitive function; LUSC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.44 5.92 0.31 7.99e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4253772 0.575 rs9615979 chr22:46789021 G/T cg00784671 chr22:46762841 CELSR1 -0.63 -6.63 -0.34 1.33e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs67079557 1 rs67079557 chr15:75930300 ATAATAAG/A cg20655648 chr15:75932815 IMP3 0.45 5.94 0.31 7.16e-9 Breast cancer; LUSC cis rs10186029 0.509 rs7566029 chr2:213941189 A/G cg08319019 chr2:214017104 IKZF2 -0.43 -6.22 -0.32 1.5e-9 Systemic sclerosis; LUSC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg04414720 chr1:150670196 GOLPH3L -0.42 -6.4 -0.33 5.4e-10 Tonsillectomy; LUSC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.18 0.55 1.7e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs62238980 0.614 rs74928243 chr22:32439681 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs11585357 0.843 rs72646796 chr1:17612503 T/C cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.11 0.32 2.72e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9814567 0.727 rs4435681 chr3:134344435 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.86 -0.58 5.11e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs7246967 0.673 rs2361260 chr19:22914144 C/T cg23217946 chr19:22817039 ZNF492 -0.41 -5.69 -0.3 2.8e-8 Bronchopulmonary dysplasia; LUSC cis rs2279817 1.000 rs4920620 chr1:18023154 A/G cg21791023 chr1:18019539 ARHGEF10L 0.46 6.34 0.33 7.58e-10 Neuroticism; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg11494091 chr17:61959527 GH2 0.63 13.49 0.59 2.1e-33 Prudent dietary pattern; LUSC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Melanoma; LUSC cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg27279351 chr12:120934652 DYNLL1 0.63 8.35 0.42 1.8e-15 High light scatter reticulocyte count; LUSC cis rs1448094 0.872 rs7314272 chr12:86401005 T/C cg00310523 chr12:86230176 RASSF9 0.37 6.77 0.35 5.98e-11 Major depressive disorder; LUSC cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg03146154 chr1:46216737 IPP 0.5 7.32 0.37 1.88e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.16 -0.36 5.16e-12 Asthma; LUSC cis rs11650494 0.908 rs73324308 chr17:47405338 T/G cg08112188 chr17:47440006 ZNF652 1.22 10.65 0.5 5.21e-23 Prostate cancer; LUSC cis rs11098499 0.754 rs2036857 chr4:120249240 T/C cg09307838 chr4:120376055 NA 0.69 10.41 0.49 3.68e-22 Corneal astigmatism; LUSC cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg05347473 chr6:146136440 FBXO30 0.52 8.65 0.43 2.21e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg12219531 chr12:120966889 COQ5 0.61 8.11 0.41 9.99e-15 High light scatter reticulocyte count; LUSC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg07061783 chr6:25882402 NA -0.42 -6.0 -0.31 5.03e-9 Blood metabolite levels; LUSC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.11 0.36 6.98e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg18225595 chr11:63971243 STIP1 0.51 6.22 0.32 1.47e-9 Mean platelet volume; LUSC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.82e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.91 -0.35 2.48e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6545883 0.894 rs2694642 chr2:61596180 A/G cg15711740 chr2:61764176 XPO1 0.44 6.72 0.35 7.83e-11 Tuberculosis; LUSC cis rs6484504 0.600 rs7122895 chr11:31346620 G/C cg26647111 chr11:31128758 NA 0.4 5.74 0.3 2.17e-8 Red blood cell count; LUSC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2652834 1.000 rs4344684 chr15:63397318 C/T cg05507819 chr15:63340323 TPM1 0.69 8.35 0.42 1.85e-15 HDL cholesterol; LUSC cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg00677455 chr12:58241039 CTDSP2 0.61 9.16 0.45 5.27e-18 Intelligence (multi-trait analysis); LUSC cis rs4654899 0.865 rs1472831 chr1:21435940 C/T cg02927042 chr1:21476669 EIF4G3 -0.39 -6.21 -0.32 1.53e-9 Superior frontal gyrus grey matter volume; LUSC cis rs12579753 0.917 rs10862360 chr12:82187411 A/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.19 -0.32 1.76e-9 Resting heart rate; LUSC cis rs1775715 0.737 rs2799018 chr10:32202069 C/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.23 0.32 1.39e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12815613 0.539 rs7300883 chr12:121459440 C/G cg02403541 chr12:121454288 C12orf43 -0.43 -5.96 -0.31 6.45e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4786125 0.920 rs6500851 chr16:6896521 A/G cg03623568 chr16:6915990 A2BP1 -0.42 -7.04 -0.36 1.1e-11 Heart rate variability traits (SDNN); LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 6.28 0.32 1.07e-9 Electroencephalogram traits; LUSC cis rs12291225 0.877 rs11023160 chr11:14264225 T/A cg05501817 chr11:14380813 RRAS2 -0.47 -6.84 -0.35 3.81e-11 Sense of smell; LUSC cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.84 -0.39 6.21e-14 Chronic sinus infection; LUSC cis rs1322512 0.917 rs2250013 chr6:153006539 A/T cg27316956 chr6:152958899 SYNE1 0.35 6.09 0.32 3.07e-9 Tonometry; LUSC cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg03146154 chr1:46216737 IPP 0.51 7.63 0.39 2.5e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4964805 0.594 rs3751204 chr12:104171455 C/T cg02344784 chr12:104178138 NT5DC3 0.37 5.97 0.31 6.08e-9 Attention deficit hyperactivity disorder; LUSC cis rs2948294 0.588 rs12544596 chr8:8116346 A/T cg15556689 chr8:8085844 FLJ10661 0.73 10.26 0.49 1.17e-21 Red cell distribution width; LUSC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -9.64 -0.47 1.4e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg06636001 chr8:8085503 FLJ10661 -0.56 -8.56 -0.42 4.1e-16 Systolic blood pressure; LUSC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.47 -7.22 -0.37 3.55e-12 Alzheimer's disease (late onset); LUSC cis rs6692729 0.933 rs6759 chr1:227069737 C/T cg10327440 chr1:227177885 CDC42BPA -0.51 -7.32 -0.37 1.91e-12 Electrodermal activity; LUSC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9790314 0.631 rs9867582 chr3:160797405 A/G cg03342759 chr3:160939853 NMD3 -0.42 -6.91 -0.35 2.48e-11 Morning vs. evening chronotype; LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg10802521 chr3:52805072 NEK4 0.5 8.08 0.4 1.19e-14 Bipolar disorder; LUSC cis rs12931792 0.782 rs12927190 chr16:30169393 C/G cg17640201 chr16:30407289 ZNF48 0.6 9.72 0.47 7.66e-20 Tonsillectomy; LUSC cis rs599083 0.744 rs603129 chr11:68186669 A/T cg20283391 chr11:68216788 NA 0.5 6.7 0.34 9.02e-11 Bone mineral density (spine); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg06643390 chr1:168106157 GPR161 0.41 6.26 0.32 1.19e-9 N-glycan levels; LUSC trans rs5756813 0.754 rs4821708 chr22:38164106 C/T cg19894588 chr14:64061835 NA -0.57 -7.49 -0.38 6.32e-13 Optic cup area;Vertical cup-disc ratio; LUSC cis rs11608355 0.538 rs11611957 chr12:109801803 A/G cg19025524 chr12:109796872 NA -0.42 -7.65 -0.39 2.18e-13 Neuroticism; LUSC trans rs7824557 0.628 rs7831346 chr8:11193530 C/T cg15556689 chr8:8085844 FLJ10661 0.47 6.96 0.36 1.84e-11 Retinal vascular caliber; LUSC cis rs317689 0.718 rs160827 chr12:69770147 G/A cg14784868 chr12:69753453 YEATS4 0.6 7.99 0.4 2.16e-14 Response to diuretic therapy; LUSC trans rs7824557 0.527 rs57629785 chr8:11235150 C/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.37 -0.33 6.31e-10 Retinal vascular caliber; LUSC cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg13010344 chr12:123464640 ARL6IP4 -0.5 -7.02 -0.36 1.27e-11 Neutrophil percentage of white cells; LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs12368653 0.666 rs701007 chr12:58113416 C/A cg18357645 chr12:58087776 OS9 0.42 6.3 0.33 9.19e-10 Multiple sclerosis; LUSC trans rs8073060 0.586 rs72829933 chr17:34056406 C/T cg19694781 chr19:47549865 TMEM160 1.14 17.37 0.69 1.31e-48 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs11168618 0.626 rs11609074 chr12:48819335 C/A cg24011408 chr12:48396354 COL2A1 0.41 6.51 0.34 2.7e-10 Adiponectin levels; LUSC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg27170947 chr2:26402098 FAM59B 0.71 10.77 0.51 2.03e-23 Gut microbiome composition (summer); LUSC cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs4820539 1.000 rs916583 chr22:23469267 C/T cg14186256 chr22:23484241 RTDR1 0.95 17.79 0.7 2.76e-50 Bone mineral density; LUSC cis rs3806843 1.000 rs6898939 chr5:140169355 C/A cg19875535 chr5:140030758 IK 0.48 7.79 0.39 8.62e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs7617773 0.963 rs9822496 chr3:48181333 T/C cg11946769 chr3:48343235 NME6 0.62 9.43 0.46 7.23e-19 Coronary artery disease; LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg25767906 chr1:53392781 SCP2 0.52 9.44 0.46 6.73e-19 Monocyte count; LUSC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg18827107 chr12:86230957 RASSF9 -0.47 -6.99 -0.36 1.55e-11 Major depressive disorder; LUSC cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.1 0.32 2.95e-9 Mean platelet volume; LUSC trans rs7618501 0.633 rs12496973 chr3:50002245 T/C cg21659725 chr3:3221576 CRBN 0.63 10.41 0.49 3.61e-22 Intelligence (multi-trait analysis); LUSC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg04121214 chr22:50244548 NA -0.34 -5.65 -0.3 3.35e-8 Schizophrenia; LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.85 0.3 1.16e-8 Menopause (age at onset); LUSC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg14895029 chr7:2775587 GNA12 -0.41 -6.22 -0.32 1.51e-9 Height; LUSC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg11366901 chr6:160182831 ACAT2 0.9 12.55 0.57 7.32e-30 Age-related macular degeneration (geographic atrophy); LUSC cis rs9392556 0.829 rs853416 chr6:4113047 A/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.34 -5.84 -0.3 1.22e-8 Blood metabolite levels; LUSC cis rs7582720 1.000 rs1541853 chr2:203835177 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg23262073 chr20:60523788 NA 0.48 6.82 0.35 4.33e-11 Body mass index; LUSC cis rs151349 0.555 rs151343 chr20:57583298 C/G cg23907860 chr20:57583709 CTSZ 0.56 9.59 0.46 2.14e-19 Platelet distribution width; LUSC cis rs72792276 1.000 rs17839658 chr5:127423013 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.92 7.8 0.39 8.18e-14 Red cell distribution width; LUSC trans rs6951245 1.000 rs75016635 chr7:1094121 G/A cg13565492 chr6:43139072 SRF -0.61 -6.37 -0.33 6.1e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs67311347 0.866 rs2371183 chr3:40334247 C/T cg09455208 chr3:40491958 NA -0.47 -8.23 -0.41 4.23e-15 Renal cell carcinoma; LUSC cis rs599083 0.530 rs491347 chr11:68169688 G/A cg01657329 chr11:68192670 LRP5 0.51 6.81 0.35 4.5e-11 Bone mineral density (spine); LUSC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg04756594 chr16:24857601 SLC5A11 -0.35 -5.83 -0.3 1.3e-8 Intelligence (multi-trait analysis); LUSC cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg14844989 chr11:31128820 NA -0.37 -5.77 -0.3 1.83e-8 Red blood cell count; LUSC cis rs7527798 0.592 rs960087 chr1:207826858 C/G cg09232269 chr1:207846808 CR1L -0.3 -6.37 -0.33 6.16e-10 Erythrocyte sedimentation rate; LUSC cis rs68170813 0.641 rs75254991 chr7:106938903 C/T cg02696742 chr7:106810147 HBP1 -0.58 -8.87 -0.44 4.46e-17 Coronary artery disease; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg22907277 chr7:1156413 C7orf50 0.68 7.3 0.37 2.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg25258033 chr6:167368657 RNASET2 0.39 6.37 0.33 6.22e-10 Crohn's disease; LUSC cis rs7605827 0.930 rs11902128 chr2:15515269 T/G cg19274914 chr2:15703543 NA 0.47 9.07 0.44 1.03e-17 Educational attainment (years of education); LUSC cis rs4474465 0.850 rs4387376 chr11:78257662 T/C cg27205649 chr11:78285834 NARS2 0.52 6.2 0.32 1.7e-9 Alzheimer's disease (survival time); LUSC cis rs2124969 0.548 rs62175384 chr2:161011128 C/T cg03641300 chr2:160917029 PLA2R1 -0.48 -5.77 -0.3 1.77e-8 Waist circumference adjusted for body mass index; LUSC cis rs1670533 1.000 rs6812596 chr4:1069866 A/G cg02018176 chr4:1364513 KIAA1530 0.45 6.37 0.33 6.14e-10 Recombination rate (females); LUSC cis rs977987 0.843 rs11649638 chr16:75488285 G/A cg03315344 chr16:75512273 CHST6 0.55 10.67 0.5 4.65e-23 Dupuytren's disease; LUSC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs4343996 0.580 rs10262464 chr7:3406961 A/C cg21248987 chr7:3385318 SDK1 0.36 6.13 0.32 2.49e-9 Motion sickness; LUSC cis rs2479724 0.870 rs3747753 chr6:41753380 G/T cg17623882 chr6:41773611 USP49 0.65 10.65 0.5 5.18e-23 Menarche (age at onset); LUSC cis rs13082711 0.911 rs17019721 chr3:27424799 A/G cg02860705 chr3:27208620 NA 0.49 8.38 0.42 1.53e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg06484146 chr7:12443880 VWDE -0.73 -7.29 -0.37 2.26e-12 Coronary artery disease; LUSC cis rs2692947 0.655 rs2315668 chr2:96429562 T/C cg23100626 chr2:96804247 ASTL 0.27 6.36 0.33 6.54e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11148252 0.532 rs9536262 chr13:53303074 A/C cg00495681 chr13:53174319 NA -0.75 -14.47 -0.62 3.39e-37 Lewy body disease; LUSC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.55 0.34 2.22e-10 Schizophrenia; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg27535305 chr1:53392650 SCP2 -0.49 -9.76 -0.47 6e-20 Monocyte count; LUSC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg11645453 chr3:52864694 ITIH4 -0.34 -8.12 -0.41 8.83e-15 Bipolar disorder; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg06145435 chr7:1022769 CYP2W1 0.3 6.19 0.32 1.77e-9 Longevity;Endometriosis; LUSC cis rs68170813 0.559 rs61406169 chr7:106903421 A/T cg02696742 chr7:106810147 HBP1 -0.65 -9.96 -0.48 1.2e-20 Coronary artery disease; LUSC cis rs12579753 0.913 rs17749243 chr12:82178079 A/C cg21231944 chr12:82153410 PPFIA2 -0.4 -6.08 -0.32 3.2e-9 Resting heart rate; LUSC cis rs10771431 0.597 rs10771412 chr12:9354353 A/C cg08997352 chr12:9597637 DDX12 -0.71 -11.07 -0.52 1.83e-24 Breast size; LUSC cis rs6121246 0.633 rs6060986 chr20:30426297 G/A cg13852791 chr20:30311386 BCL2L1 0.88 13.16 0.58 3.87e-32 Mean corpuscular hemoglobin; LUSC cis rs9287719 0.745 rs4997809 chr2:10755542 G/A cg00105475 chr2:10696890 NA 0.36 5.81 0.3 1.42e-8 Prostate cancer; LUSC cis rs782590 0.967 rs1084522 chr2:55843294 A/G cg03859395 chr2:55845619 SMEK2 0.88 16.64 0.67 1.09e-45 Metabolic syndrome; LUSC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg04850211 chr1:228464232 OBSCN -0.33 -6.14 -0.32 2.28e-9 Diastolic blood pressure; LUSC cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.39 -6.07 -0.31 3.56e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs853679 1.000 rs853678 chr6:28297313 T/A cg01620082 chr3:125678407 NA -0.57 -6.5 -0.34 2.91e-10 Depression; LUSC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg03676636 chr4:99064102 C4orf37 0.27 5.81 0.3 1.46e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs25645 0.502 rs7209742 chr17:38108708 A/G cg26162295 chr17:38119207 GSDMA -0.28 -6.33 -0.33 8.07e-10 Myeloid white cell count; LUSC cis rs17270561 0.636 rs6456694 chr6:25712894 C/T cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.35e-17 Iron status biomarkers; LUSC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg07636037 chr3:49044803 WDR6 1.04 18.83 0.72 2.12e-54 Parkinson's disease; LUSC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg01448562 chr3:133502909 NA -0.52 -7.75 -0.39 1.12e-13 Iron status biomarkers; LUSC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg08270630 chr22:50330655 NA -0.42 -6.29 -0.33 1e-9 Schizophrenia; LUSC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg22875332 chr1:76189707 ACADM 0.77 10.46 0.5 2.41e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12542260 0.871 rs62527884 chr8:125483344 A/G cg27038428 chr8:125485867 RNF139 0.33 6.71 0.34 8.12e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg10978503 chr1:24200527 CNR2 0.53 13.15 0.58 4.1e-32 Immature fraction of reticulocytes; LUSC cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg24812749 chr6:127587940 RNF146 0.81 11.85 0.54 2.82e-27 Breast cancer; LUSC cis rs709400 0.567 rs28496120 chr14:103897899 C/T cg24130564 chr14:104152367 KLC1 -0.43 -6.11 -0.32 2.81e-9 Body mass index; LUSC cis rs2486288 0.656 rs11639349 chr15:45568260 C/T cg09092052 chr15:45571596 NA 0.48 6.67 0.34 1.04e-10 Glomerular filtration rate; LUSC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11644478 chr21:40555479 PSMG1 0.94 18.8 0.72 2.63e-54 Cognitive function; LUSC trans rs9747201 0.926 rs8065606 chr17:80063526 G/A cg07393940 chr7:158741817 NA -0.55 -8.33 -0.41 2.08e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10911363 0.615 rs12024309 chr1:183419981 A/G cg09173681 chr1:183549694 NCF2 -0.63 -11.13 -0.52 1.12e-24 Systemic lupus erythematosus; LUSC cis rs9399135 0.967 rs9389253 chr6:135329755 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.12 0.45 7.4e-18 Red blood cell count; LUSC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.69 11.54 0.53 3.79e-26 Menarche (age at onset); LUSC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg07701084 chr6:150067640 NUP43 0.49 7.27 0.37 2.56e-12 Lung cancer; LUSC cis rs5758659 0.679 rs134870 chr22:42652317 T/C cg00645731 chr22:42541494 CYP2D7P1 -0.29 -6.16 -0.32 2.03e-9 Cognitive function; LUSC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg17279839 chr7:150038598 RARRES2 0.48 7.55 0.38 4.17e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs727505 0.564 rs67745021 chr7:124868018 T/C cg23710748 chr7:124431027 NA -0.39 -6.71 -0.34 8.19e-11 Lewy body disease; LUSC cis rs16910800 1.000 rs73479578 chr11:23197173 C/T cg20040320 chr11:23191996 NA -0.45 -6.59 -0.34 1.68e-10 Cancer; LUSC cis rs727505 0.564 rs56068095 chr7:124831906 A/T cg23710748 chr7:124431027 NA -0.4 -6.85 -0.35 3.6e-11 Lewy body disease; LUSC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg03709012 chr19:19516395 GATAD2A -0.83 -13.78 -0.6 1.6e-34 Tonsillectomy; LUSC cis rs10791097 0.677 rs11222359 chr11:130730648 A/G cg12179176 chr11:130786555 SNX19 0.74 12.09 0.55 3.65e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg01256987 chr12:42539512 GXYLT1 -0.46 -8.67 -0.43 1.97e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg00484396 chr16:3507460 NAT15 -0.91 -10.66 -0.5 4.91e-23 Tuberculosis; LUSC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg19748678 chr4:122722346 EXOSC9 0.49 7.67 0.39 1.92e-13 Type 2 diabetes; LUSC cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14240646 chr10:27532245 ACBD5 -0.67 -7.68 -0.39 1.74e-13 Breast cancer; LUSC cis rs6901250 0.851 rs339307 chr6:117177340 A/G cg12892004 chr6:117198278 RFX6 -0.45 -8.51 -0.42 5.97e-16 C-reactive protein levels; LUSC cis rs4319547 0.695 rs11057797 chr12:122860732 G/A cg05707623 chr12:122985044 ZCCHC8 0.66 8.18 0.41 5.92e-15 Body mass index; LUSC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg21699342 chr2:239360505 ASB1 0.56 10.55 0.5 1.18e-22 Multiple system atrophy; LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs877282 1.000 rs12775643 chr10:773242 G/A cg17470449 chr10:769945 NA 0.5 7.0 0.36 1.41e-11 Uric acid levels; LUSC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg17948913 chr5:572064 NA 0.33 5.64 0.3 3.56e-8 Lung disease severity in cystic fibrosis; LUSC cis rs1797081 0.934 rs1797077 chr10:16853252 C/T cg23933602 chr10:16859644 RSU1 1.05 23.79 0.79 7.14e-74 Platelet distribution width; LUSC cis rs4727027 0.704 rs13229244 chr7:148898219 A/C cg23583168 chr7:148888333 NA 0.9 17.96 0.7 5.85e-51 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg17264618 chr3:40429014 ENTPD3 0.34 7.27 0.37 2.55e-12 Renal cell carcinoma; LUSC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg17971929 chr21:40555470 PSMG1 -0.68 -10.94 -0.51 5.01e-24 Cognitive function; LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg11496811 chr1:181058973 IER5 0.37 5.99 0.31 5.5e-9 Major depressive disorder; LUSC cis rs2857891 0.817 rs2239732 chr11:6976689 C/G cg14883916 chr11:6947541 ZNF215 0.46 5.91 0.31 8.31e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2637266 0.905 rs34173296 chr10:78343389 C/T cg18941641 chr10:78392320 NA 0.32 5.76 0.3 1.9e-8 Pulmonary function; LUSC cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.35 -0.46 1.28e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs861020 0.771 rs674804 chr1:210014603 C/G cg05527609 chr1:210001259 C1orf107 1.03 15.05 0.64 1.87e-39 Orofacial clefts; LUSC cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.84 -0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg11244672 chr19:19639970 YJEFN3 0.61 7.8 0.39 7.88e-14 Bipolar disorder; LUSC cis rs9527 0.830 rs10883790 chr10:104640955 A/C cg05855489 chr10:104503620 C10orf26 0.47 6.51 0.34 2.69e-10 Arsenic metabolism; LUSC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.38 6.21 0.32 1.61e-9 Menopause (age at onset); LUSC trans rs79976124 0.879 rs12214239 chr6:66636059 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 8.73 0.43 1.28e-16 Type 2 diabetes; LUSC cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg10621924 chr7:39171070 POU6F2 0.44 6.4 0.33 5.35e-10 IgG glycosylation; LUSC cis rs1190552 0.595 rs2403039 chr14:102820163 C/A cg18135206 chr14:102964638 TECPR2 -0.42 -5.82 -0.3 1.35e-8 Blood protein levels; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.73 10.59 0.5 8.79e-23 Alzheimer's disease; LUSC trans rs13314892 1.000 rs9817946 chr3:69795157 A/G cg24703757 chr4:183838736 DCTD 0.47 6.19 0.32 1.79e-9 QRS complex (12-leadsum); LUSC cis rs34734847 0.787 rs658521 chr12:121162414 G/T cg21892295 chr12:121157589 UNC119B -0.36 -6.31 -0.33 9.08e-10 Mean corpuscular volume; LUSC cis rs3126085 0.935 rs11204937 chr1:152193851 C/T cg26876637 chr1:152193138 HRNR 0.43 6.24 0.32 1.34e-9 Atopic dermatitis; LUSC cis rs8027181 1.000 rs3850986 chr15:73091283 G/T cg25632853 chr15:73088954 NA 0.34 6.61 0.34 1.55e-10 Triglyceride levels; LUSC cis rs2074977 0.530 rs10401784 chr19:3445721 A/C cg08380311 chr19:3435252 NFIC 0.63 10.04 0.48 6.46e-21 Height; LUSC cis rs7582180 0.614 rs9973737 chr2:100942296 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.56 -0.42 4.3e-16 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.71e-13 Bipolar disorder; LUSC trans rs4942242 0.663 rs9525812 chr13:44200099 T/C cg19169023 chr15:41853346 TYRO3 -0.61 -9.17 -0.45 4.87e-18 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg06544989 chr22:39130855 UNC84B 0.32 5.65 0.3 3.48e-8 Menopause (age at onset); LUSC cis rs422249 0.512 rs174577 chr11:61604814 A/C cg19610905 chr11:61596333 FADS2 0.49 7.49 0.38 6.31e-13 Trans fatty acid levels; LUSC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg07424592 chr7:64974309 NA 0.68 5.96 0.31 6.3e-9 Diabetic kidney disease; LUSC cis rs4474465 0.920 rs7396701 chr11:78202699 A/C cg27205649 chr11:78285834 NARS2 0.51 6.0 0.31 5.07e-9 Alzheimer's disease (survival time); LUSC trans rs57046232 0.552 rs6038445 chr20:6329093 A/G cg17788362 chr6:86352627 SYNCRIP 0.45 6.23 0.32 1.38e-9 Colorectal cancer; LUSC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg06697600 chr4:7070879 GRPEL1 -0.44 -7.21 -0.37 3.88e-12 Monocyte percentage of white cells; LUSC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg13390004 chr1:15929781 NA 0.4 6.6 0.34 1.6e-10 Systolic blood pressure; LUSC cis rs4704187 0.687 rs4703655 chr5:74455063 A/G cg03227963 chr5:74354835 NA 0.31 6.8 0.35 4.74e-11 Response to amphetamines; LUSC cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg12935359 chr14:103987150 CKB -0.56 -8.94 -0.44 2.72e-17 Intelligence (multi-trait analysis); LUSC cis rs243505 0.898 rs243529 chr7:148413801 G/A cg09806900 chr7:148480153 CUL1 -0.47 -6.64 -0.34 1.3e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC trans rs617791 0.530 rs7952056 chr11:65744597 C/T cg17712092 chr4:129076599 LARP1B -0.73 -10.26 -0.49 1.19e-21 Breast cancer; LUSC cis rs12681287 0.517 rs34367154 chr8:87508749 A/T cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs10761482 0.906 rs2199209 chr10:62094738 A/G cg18175470 chr10:62150864 ANK3 -0.45 -6.52 -0.34 2.65e-10 Schizophrenia; LUSC cis rs2439831 0.867 rs496584 chr15:43831923 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.84 9.25 0.45 2.7e-18 Lung cancer in ever smokers; LUSC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg02825527 chr7:2087843 MAD1L1 -0.5 -5.73 -0.3 2.29e-8 Bipolar disorder; LUSC trans rs2197308 0.728 rs7304305 chr12:37932990 T/C cg06521331 chr12:34319734 NA 0.4 6.32 0.33 8.45e-10 Morning vs. evening chronotype; LUSC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.67 0.39 1.95e-13 Vitiligo; LUSC cis rs11190604 1.000 rs7905961 chr10:102297391 G/C cg07080220 chr10:102295463 HIF1AN 0.68 9.51 0.46 3.98e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg06481639 chr22:41940642 POLR3H 0.51 5.8 0.3 1.51e-8 Vitiligo; LUSC cis rs56283067 0.578 rs62400353 chr6:45387899 G/A cg18551225 chr6:44695536 NA -0.4 -5.82 -0.3 1.41e-8 Total body bone mineral density; LUSC cis rs7208859 0.623 rs8075163 chr17:29106310 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg19717773 chr7:2847554 GNA12 -0.4 -6.26 -0.32 1.15e-9 Height; LUSC trans rs11098499 0.644 rs17517414 chr4:120262101 G/C cg25214090 chr10:38739885 LOC399744 0.41 6.28 0.32 1.05e-9 Corneal astigmatism; LUSC cis rs5769707 0.632 rs135872 chr22:50009300 T/C cg20744362 chr22:50050164 C22orf34 0.39 7.07 0.36 9.14e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.4 0.62 6.35e-37 Platelet count; LUSC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs8062405 1.000 rs72793811 chr16:28839392 G/A cg09754948 chr16:28834200 ATXN2L 0.43 6.33 0.33 8.06e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04358685 chr3:12598421 MKRN2 0.48 7.87 0.4 5e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.790 rs2425083 chr20:34300456 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.58 -0.46 2.3e-19 Total cholesterol levels; LUSC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1775715 0.707 rs2808087 chr10:32146444 C/G cg18675610 chr10:32216311 ARHGAP12 0.31 6.87 0.35 3.21e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs3126085 0.935 rs11204951 chr1:152224404 A/G cg26876637 chr1:152193138 HRNR 0.45 6.5 0.34 2.94e-10 Atopic dermatitis; LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg12432903 chr7:1882776 MAD1L1 -0.39 -6.38 -0.33 6.06e-10 Bipolar disorder and schizophrenia; LUSC cis rs317689 1.000 rs317689 chr12:69727190 G/A cg20891283 chr12:69753455 YEATS4 0.54 7.2 0.37 3.95e-12 Response to diuretic therapy; LUSC cis rs9747201 0.926 rs34153075 chr17:80135728 C/A cg18209359 chr17:80159595 CCDC57 0.4 6.76 0.35 6.12e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6076065 0.775 rs6083114 chr20:23379528 G/T cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs7903847 0.620 rs7923385 chr10:99117097 T/A cg20016023 chr10:99160130 RRP12 -0.32 -7.69 -0.39 1.72e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs7809950 0.678 rs62482499 chr7:106975059 C/G cg23024343 chr7:107201750 COG5 -0.64 -9.62 -0.47 1.75e-19 Coronary artery disease; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC cis rs7829975 0.582 rs6983150 chr8:8792426 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.4 -0.42 1.28e-15 Mood instability; LUSC trans rs6852435 1.000 rs35920928 chr4:175315923 G/C cg23753247 chr11:8615842 STK33 -0.53 -5.97 -0.31 5.91e-9 Response to acetaminophen (hepatotoxicity); LUSC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg13390004 chr1:15929781 NA 0.42 7.02 0.36 1.23e-11 Systolic blood pressure; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg02018176 chr4:1364513 KIAA1530 0.52 8.93 0.44 2.96e-17 Obesity-related traits; LUSC cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg05855489 chr10:104503620 C10orf26 0.64 9.26 0.45 2.55e-18 Arsenic metabolism; LUSC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg06713675 chr4:122721982 EXOSC9 -0.66 -11.42 -0.53 1.02e-25 Type 2 diabetes; LUSC cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg08704250 chr15:31115839 NA -0.46 -6.84 -0.35 3.88e-11 Huntington's disease progression; LUSC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg27266060 chr8:22091797 NA 0.41 7.57 0.38 3.69e-13 Hypertriglyceridemia; LUSC cis rs9788721 0.836 rs17484235 chr15:78761414 C/G cg18825076 chr15:78729989 IREB2 -0.64 -10.33 -0.49 6.71e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg05623727 chr3:50126028 RBM5 0.31 5.81 0.3 1.43e-8 Body mass index; LUSC cis rs13031619 0.517 rs10864995 chr2:3683557 C/T cg10645314 chr2:3704589 ALLC -0.45 -5.95 -0.31 6.64e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 13.48 0.59 2.34e-33 Platelet count; LUSC trans rs11098499 0.818 rs55825515 chr4:120486402 A/G cg25214090 chr10:38739885 LOC399744 0.54 7.81 0.39 7.48e-14 Corneal astigmatism; LUSC cis rs748404 0.697 rs505249 chr15:43559960 T/A cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.82 0.3 1.35e-8 Lung cancer; LUSC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.98 -0.31 5.87e-9 Reticulocyte fraction of red cells; LUSC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg15691649 chr6:25882328 NA -0.47 -6.62 -0.34 1.44e-10 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg27170947 chr2:26402098 FAM59B 0.69 8.86 0.44 4.85e-17 Gut microbiome composition (summer); LUSC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg16339924 chr4:17578868 LAP3 0.55 8.37 0.42 1.57e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg15790184 chr11:494944 RNH1 0.42 6.4 0.33 5.37e-10 Systemic lupus erythematosus; LUSC cis rs9303401 0.646 rs9892425 chr17:57241938 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.43 6.38 0.33 5.85e-10 Cognitive test performance; LUSC cis rs6500395 1.000 rs2354579 chr16:48601521 T/C cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9325144 0.624 rs7312879 chr12:39150752 G/A cg13010199 chr12:38710504 ALG10B -0.48 -7.43 -0.38 9.29e-13 Morning vs. evening chronotype; LUSC cis rs2387326 0.717 rs77277629 chr10:129944462 C/T cg16087940 chr10:129947807 NA -0.38 -5.78 -0.3 1.7e-8 Select biomarker traits; LUSC cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 0.33 6.58 0.34 1.85e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg13319975 chr6:146136371 FBXO30 0.52 7.73 0.39 1.29e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.51 -0.38 5.35e-13 Aortic root size; LUSC trans rs4538187 0.951 rs17562177 chr2:64160385 A/G cg06706163 chr13:25497100 CENPJ 0.54 6.05 0.31 3.95e-9 Systolic blood pressure; LUSC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg19592336 chr6:28129416 ZNF389 0.48 6.27 0.32 1.11e-9 Depression; LUSC cis rs9653442 0.576 rs6542921 chr2:100864498 C/A cg22139774 chr2:100720529 AFF3 -0.38 -6.21 -0.32 1.58e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.77 13.38 0.59 5.72e-33 Menarche (age at onset); LUSC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.01 0.4 1.9e-14 Parkinson's disease; LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9393777 0.623 rs7756567 chr6:26481642 T/G cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC cis rs34172651 0.837 rs12596793 chr16:24823667 C/G cg00152838 chr16:24741724 TNRC6A -0.43 -5.65 -0.3 3.5e-8 Intelligence (multi-trait analysis); LUSC cis rs9837602 1.000 rs1688766 chr3:99647850 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.43 0.33 4.49e-10 Breast cancer; LUSC cis rs807669 0.802 rs762528 chr22:19166680 A/G cg02655711 chr22:19163373 SLC25A1 0.91 18.15 0.7 9.95e-52 Metabolite levels; LUSC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg06494592 chr3:125709126 NA -0.51 -5.81 -0.3 1.47e-8 Blood pressure (smoking interaction); LUSC cis rs394563 0.601 rs432582 chr6:149794143 C/T cg07828024 chr6:149772892 ZC3H12D -0.39 -7.94 -0.4 3.11e-14 Dupuytren's disease; LUSC cis rs11428934 1 rs11428934 chr19:49144245 T/TG cg06530960 chr19:49140787 SEC1;DBP 0.53 7.27 0.37 2.57e-12 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Granulocyte count; LUSC cis rs6692729 0.966 rs6426548 chr1:227013878 C/T cg10327440 chr1:227177885 CDC42BPA 0.48 6.9 0.35 2.63e-11 Electrodermal activity; LUSC cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.47 0.38 7.15e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs478304 0.651 rs948493 chr11:65552154 C/T cg10518572 chr11:65560635 OVOL1 -0.27 -6.2 -0.32 1.71e-9 Acne (severe); LUSC cis rs11822910 0.654 rs2439450 chr11:57213061 C/G cg24343310 chr11:57249947 NA -0.42 -7.72 -0.39 1.34e-13 Platelet distribution width; LUSC cis rs8072100 0.840 rs9900360 chr17:45491979 C/T cg08085267 chr17:45401833 C17orf57 -0.54 -8.67 -0.43 1.94e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg25482853 chr8:67687455 SGK3 1.21 19.41 0.73 1e-56 Lung disease severity in cystic fibrosis; LUSC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg19592336 chr6:28129416 ZNF389 0.49 6.36 0.33 6.73e-10 Depression; LUSC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg21138405 chr5:131827807 IRF1 -0.59 -11.59 -0.54 2.39e-26 Asthma (sex interaction); LUSC cis rs4629180 0.727 rs10188564 chr2:102101064 C/A cg01388757 chr2:102091195 RFX8 -0.45 -7.06 -0.36 9.48e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs2635047 0.756 rs34939493 chr18:44795621 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.84 0.3 1.23e-8 Educational attainment; LUSC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.55 0.46 2.84e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs10489202 0.608 rs10800334 chr1:168075613 T/C cg24449463 chr1:168025552 DCAF6 -0.65 -9.67 -0.47 1.13e-19 Schizophrenia; LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4654899 0.865 rs6685831 chr1:21507888 G/A cg01072550 chr1:21505969 NA -0.49 -7.34 -0.37 1.63e-12 Superior frontal gyrus grey matter volume; LUSC cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.12 0.55 2.87e-28 Motion sickness; LUSC trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg13615516 chr5:77269221 NA 0.4 6.76 0.35 6.09e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.61 10.09 0.48 4.47e-21 Lymphocyte counts; LUSC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg13647721 chr17:30228624 UTP6 0.64 6.43 0.33 4.46e-10 Hip circumference adjusted for BMI; LUSC cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg02503808 chr4:7069936 GRPEL1 0.56 8.75 0.43 1.04e-16 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg02753203 chr1:228287806 NA -0.66 -11.19 -0.52 6.69e-25 Diastolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23989878 chr6:42018162 TAF8 -0.4 -5.98 -0.31 5.78e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1670533 0.932 rs13106586 chr4:1054182 G/A cg16405210 chr4:1374714 KIAA1530 -0.46 -5.64 -0.3 3.56e-8 Recombination rate (females); LUSC cis rs9549260 0.755 rs7985364 chr13:41179580 C/G cg21288729 chr13:41239152 FOXO1 0.59 8.8 0.43 7.54e-17 Red blood cell count; LUSC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg27432699 chr2:27873401 GPN1 -0.57 -8.49 -0.42 6.77e-16 Total body bone mineral density; LUSC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg17971929 chr21:40555470 PSMG1 -0.63 -10.25 -0.49 1.31e-21 Cognitive function; LUSC cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC trans rs7615952 0.546 rs11718647 chr3:125352022 G/A cg07211511 chr3:129823064 LOC729375 -0.5 -5.97 -0.31 5.9e-9 Blood pressure (smoking interaction); LUSC cis rs1950626 0.577 rs61991118 chr14:101441974 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.47 0.38 6.94e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs6840360 0.615 rs4696268 chr4:152464723 G/A cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs9467773 0.596 rs2451751 chr6:26646714 T/C cg09904177 chr6:26538194 HMGN4 0.66 11.81 0.54 3.86e-27 Intelligence (multi-trait analysis); LUSC cis rs7123876 0.553 rs12099027 chr11:72433920 A/G cg03878208 chr11:72483293 STARD10 0.37 5.86 0.31 1.11e-8 Body mass index; LUSC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg22166914 chr1:53195759 ZYG11B 0.67 11.31 0.53 2.54e-25 Monocyte count; LUSC cis rs72781680 0.752 rs72796119 chr2:23917179 C/T cg20701182 chr2:24300061 SF3B14 0.72 7.07 0.36 8.9e-12 Lymphocyte counts; LUSC cis rs17092148 0.895 rs4417778 chr20:33350987 T/C cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs1728785 1.000 rs698712 chr16:68561879 G/A cg02972257 chr16:68554789 NA -0.48 -6.19 -0.32 1.76e-9 Ulcerative colitis; LUSC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.67 -0.39 1.9e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg08999081 chr20:33150536 PIGU -0.52 -10.55 -0.5 1.24e-22 Glomerular filtration rate (creatinine); LUSC trans rs12579753 0.956 rs7959951 chr12:82231132 T/C cg07923666 chr12:49932857 KCNH3 -0.54 -6.63 -0.34 1.38e-10 Resting heart rate; LUSC trans rs8073060 0.586 rs188959 chr17:34021307 C/A cg19694781 chr19:47549865 TMEM160 -1.13 -17.99 -0.7 4.71e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -11.29 -0.53 2.85e-25 Systemic lupus erythematosus; LUSC cis rs17270561 0.583 rs6926425 chr6:25785304 T/C cg16482183 chr6:26056742 HIST1H1C 0.51 7.23 0.37 3.4e-12 Iron status biomarkers; LUSC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.88 0.48 2.35e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1997103 1.000 rs1965556 chr7:55403584 C/G cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2758596 1.000 rs2842866 chr1:156159721 G/A cg25208724 chr1:156163844 SLC25A44 0.78 6.37 0.33 6.32e-10 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs950027 0.549 rs2899375 chr15:45598335 G/A cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.81 -0.39 7.32e-14 Response to fenofibrate (adiponectin levels); LUSC trans rs17278117 0.614 rs73010754 chr4:182595778 G/A cg11957848 chr6:169575326 NA 0.64 6.08 0.32 3.31e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs400736 0.930 rs225100 chr1:8066914 C/T cg25007680 chr1:8021821 PARK7 -0.58 -9.09 -0.45 9.16e-18 Response to antidepressants and depression; LUSC cis rs7824557 0.564 rs2572399 chr8:11234520 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.99 -0.31 5.34e-9 Retinal vascular caliber; LUSC trans rs3733585 0.673 rs4235348 chr4:9951968 T/C cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.13e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6489882 0.836 rs10774676 chr12:113362407 C/T cg20102336 chr12:113376681 OAS3 0.43 6.13 0.32 2.43e-9 Chronic lymphocytic leukemia; LUSC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg25019033 chr10:957182 NA -0.52 -6.57 -0.34 1.95e-10 Eosinophil percentage of granulocytes; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg16031515 chr1:205743344 RAB7L1 -0.28 -6.12 -0.32 2.63e-9 Menarche (age at onset); LUSC cis rs936229 1.000 rs936228 chr15:75132164 T/C cg14664628 chr15:75095509 CSK -0.9 -14.12 -0.61 7.87e-36 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.14 -0.32 2.37e-9 Life satisfaction; LUSC cis rs17539620 0.624 rs111868524 chr6:154839960 G/C cg20019720 chr6:154832845 CNKSR3 0.63 8.74 0.43 1.17e-16 Lipoprotein (a) levels; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg11494091 chr17:61959527 GH2 0.65 13.92 0.61 4.91e-35 Prudent dietary pattern; LUSC cis rs1801251 1.000 rs1446311 chr2:233705071 G/A cg08000102 chr2:233561755 GIGYF2 -0.7 -11.58 -0.54 2.72e-26 Coronary artery disease; LUSC cis rs7617773 0.817 rs936427 chr3:48301074 A/G cg11946769 chr3:48343235 NME6 -0.85 -13.86 -0.6 7.84e-35 Coronary artery disease; LUSC trans rs7826238 0.720 rs12546760 chr8:8374836 A/G cg27411982 chr8:10470053 RP1L1 -0.43 -6.81 -0.35 4.59e-11 Systolic blood pressure; LUSC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg12639453 chr1:2035780 PRKCZ -0.3 -6.36 -0.33 6.48e-10 Height; LUSC cis rs911555 0.504 rs8006526 chr14:104075015 T/C cg12935359 chr14:103987150 CKB -0.51 -7.87 -0.4 4.9e-14 Intelligence (multi-trait analysis); LUSC cis rs11158026 0.757 rs2183085 chr14:55472391 A/C cg04306507 chr14:55594613 LGALS3 0.36 7.15 0.36 5.6e-12 Parkinson's disease; LUSC cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg00484396 chr16:3507460 NAT15 -0.42 -6.75 -0.35 6.69e-11 Body mass index (adult); LUSC cis rs9929218 0.954 rs2059254 chr16:68817439 C/T cg02972257 chr16:68554789 NA 0.42 5.89 0.31 9.48e-9 Colorectal cancer; LUSC cis rs1941023 0.606 rs7926219 chr11:60180335 C/T cg08716584 chr11:60157161 MS4A7 -0.56 -10.26 -0.49 1.16e-21 Congenital heart disease (maternal effect); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg19777998 chr3:11762192 VGLL4 0.42 6.58 0.34 1.86e-10 Schizophrenia; LUSC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg06808227 chr14:105710500 BRF1 -0.68 -10.94 -0.51 5.14e-24 Mean platelet volume;Platelet distribution width; LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.47 5.88 0.31 9.99e-9 Renal function-related traits (BUN); LUSC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.66 -0.39 2.07e-13 Bipolar disorder; LUSC cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg04586622 chr2:25135609 ADCY3 0.43 9.16 0.45 5.26e-18 Body mass index; LUSC cis rs1691799 0.899 rs1168322 chr12:66743769 C/T cg16791601 chr12:66731901 HELB -0.71 -12.56 -0.57 7e-30 White blood cell count (basophil); LUSC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg05623727 chr3:50126028 RBM5 0.34 6.39 0.33 5.71e-10 Intelligence (multi-trait analysis); LUSC trans rs1005277 0.579 rs2504148 chr10:38400788 A/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.55 -0.46 2.91e-19 Extrinsic epigenetic age acceleration; LUSC trans rs208520 0.690 rs74707865 chr6:66717352 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.78 0.68 2.97e-46 Exhaled nitric oxide output; LUSC cis rs7100689 0.784 rs1870142 chr10:82182296 G/A cg01528321 chr10:82214614 TSPAN14 1.15 18.48 0.71 5.09e-53 Post bronchodilator FEV1; LUSC cis rs1865760 0.865 rs1436306 chr6:25948421 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 7.03 0.36 1.17e-11 Height; LUSC cis rs1949733 0.598 rs16842480 chr4:8535621 G/T cg11789530 chr4:8429930 ACOX3 -0.44 -6.52 -0.34 2.56e-10 Response to antineoplastic agents; LUSC cis rs9902453 0.765 rs8071576 chr17:28188554 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.23 0.52 4.92e-25 Coffee consumption (cups per day); LUSC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg06634786 chr22:41940651 POLR3H 0.51 6.11 0.32 2.72e-9 Vitiligo; LUSC cis rs7100689 0.646 rs10749573 chr10:82136839 T/A cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs7107174 1.000 rs2512532 chr11:77968641 T/C cg02023728 chr11:77925099 USP35 0.5 7.24 0.37 3.13e-12 Testicular germ cell tumor; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -10.28 -0.49 9.82e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6480314 0.542 rs17231644 chr10:70030058 C/T cg04882175 chr6:131122610 NA 0.53 6.03 0.31 4.46e-9 Optic nerve measurement (disc area); LUSC cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 8.78 0.43 8.68e-17 Colorectal cancer; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg18765753 chr7:1198926 ZFAND2A -0.54 -9.72 -0.47 8.16e-20 Longevity;Endometriosis; LUSC cis rs3772130 1.000 rs56314138 chr3:121356656 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.67 9.62 0.47 1.71e-19 Cognitive performance; LUSC trans rs28735056 0.904 rs11520415 chr18:77620620 C/T cg05926928 chr17:57297772 GDPD1 0.51 7.33 0.37 1.8e-12 Schizophrenia; LUSC cis rs977987 0.843 rs12927562 chr16:75482860 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.04 -0.36 1.07e-11 Dupuytren's disease; LUSC cis rs7527798 0.592 rs10746386 chr1:207855095 C/T cg09232269 chr1:207846808 CR1L -0.31 -6.71 -0.34 8.55e-11 Erythrocyte sedimentation rate; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05571413 chr17:47841772 FAM117A -0.4 -5.95 -0.31 6.83e-9 Electrocardiographic conduction measures; LUSC cis rs9355610 0.609 rs9366076 chr6:167373708 C/T cg23791538 chr6:167370224 RNASET2 0.41 5.82 0.3 1.4e-8 Graves' disease; LUSC cis rs10751667 0.961 rs6597951 chr11:991530 C/T cg06064525 chr11:970664 AP2A2 -0.36 -7.06 -0.36 9.65e-12 Alzheimer's disease (late onset); LUSC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg13334819 chr7:99746414 C7orf59 -0.44 -5.8 -0.3 1.51e-8 Coronary artery disease; LUSC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg00484396 chr16:3507460 NAT15 0.71 12.42 0.56 2.24e-29 Tuberculosis; LUSC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 8.68 0.43 1.78e-16 Melanoma; LUSC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg02038168 chr22:39784481 NA -0.49 -8.22 -0.41 4.44e-15 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg02951883 chr7:2050386 MAD1L1 -0.61 -11.45 -0.53 7.86e-26 Bipolar disorder and schizophrenia; LUSC trans rs7980799 0.649 rs12819439 chr12:33684509 A/C cg26384229 chr12:38710491 ALG10B 0.57 8.16 0.41 6.8e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs921968 0.541 rs10205073 chr2:219412784 C/A cg02176678 chr2:219576539 TTLL4 -0.74 -14.43 -0.62 5.11e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs6940638 0.688 rs9379960 chr6:27121325 A/C cg09904177 chr6:26538194 HMGN4 -0.47 -6.89 -0.35 2.83e-11 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg15147215 chr3:52552868 STAB1 -0.3 -5.96 -0.31 6.55e-9 Bipolar disorder; LUSC cis rs7769051 0.522 rs9493449 chr6:133126179 T/A cg07930552 chr6:133119739 C6orf192 0.94 8.39 0.42 1.41e-15 Type 2 diabetes nephropathy; LUSC cis rs10489202 0.608 rs7556350 chr1:168077797 C/T cg24449463 chr1:168025552 DCAF6 -0.64 -9.52 -0.46 3.62e-19 Schizophrenia; LUSC cis rs1008375 1.000 rs9991307 chr4:17662408 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.74 0.35 6.94e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7824557 0.606 rs2736273 chr8:11199938 C/A cg06636001 chr8:8085503 FLJ10661 0.54 7.99 0.4 2.18e-14 Retinal vascular caliber; LUSC cis rs7666738 0.546 rs13148080 chr4:98680947 A/G cg03676636 chr4:99064102 C4orf37 0.31 6.13 0.32 2.47e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.43 -7.6 -0.38 2.99e-13 Breast cancer; LUSC cis rs79839061 0.520 rs6842808 chr4:906903 C/T cg14530993 chr4:882597 GAK 0.63 6.66 0.34 1.15e-10 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg26314531 chr2:26401878 FAM59B 0.73 10.21 0.49 1.79e-21 Gut microbiome composition (summer); LUSC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg06481639 chr22:41940642 POLR3H -0.52 -6.35 -0.33 7.24e-10 Vitiligo; LUSC cis rs1419980 0.730 rs12321773 chr12:7797967 G/A cg10578777 chr12:7781093 NA 0.6 5.65 0.3 3.42e-8 HDL cholesterol levels; LUSC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.51 -0.73 4.02e-57 Height; LUSC cis rs9419702 0.568 rs11156445 chr10:133542301 T/C cg23460707 chr10:133558971 NA 0.33 5.81 0.3 1.48e-8 Survival in rectal cancer; LUSC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs73195822 0.773 rs10849903 chr12:111112319 T/C cg12870014 chr12:110450643 ANKRD13A 0.75 9.66 0.47 1.3e-19 Itch intensity from mosquito bite; LUSC cis rs9393692 0.645 rs766406 chr6:26319588 G/T cg13736514 chr6:26305472 NA -0.58 -11.35 -0.53 1.78e-25 Educational attainment; LUSC cis rs2180341 0.618 rs6683 chr6:127610021 G/A cg27446573 chr6:127587934 RNF146 0.64 10.35 0.49 6.01e-22 Breast cancer; LUSC cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg26384229 chr12:38710491 ALG10B 0.84 13.8 0.6 1.32e-34 Bladder cancer; LUSC cis rs9462027 0.583 rs2744974 chr6:34579431 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.97 -0.31 5.9e-9 Systemic lupus erythematosus; LUSC cis rs738322 0.870 rs2277844 chr22:38577515 G/A cg25457927 chr22:38595422 NA 0.44 9.26 0.45 2.64e-18 Cutaneous nevi; LUSC cis rs17092148 1.000 rs1884431 chr20:33338585 G/A cg16810054 chr20:33298113 TP53INP2 -0.39 -6.26 -0.32 1.18e-9 Neuroticism; LUSC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg05855489 chr10:104503620 C10orf26 0.6 9.44 0.46 6.77e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4919087 1.000 rs4919089 chr10:99087905 G/A cg25902810 chr10:99078978 FRAT1 -0.46 -6.7 -0.34 8.72e-11 Monocyte count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22728323 chr8:37887713 EIF4EBP1 -0.4 -6.02 -0.31 4.55e-9 Electrocardiographic conduction measures; LUSC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg06238570 chr21:40685208 BRWD1 0.46 7.08 0.36 8.59e-12 Cognitive function; LUSC trans rs2635047 0.624 rs2289036 chr18:44595809 A/T cg10297561 chr8:49231655 NA 0.36 5.97 0.31 5.99e-9 Educational attainment; LUSC cis rs926392 0.896 rs742276 chr20:37679849 C/T cg27552599 chr20:37590471 DHX35 0.34 5.99 0.31 5.35e-9 Dialysis-related mortality; LUSC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.49 -5.84 -0.3 1.26e-8 Menarche (age at onset); LUSC cis rs11758351 0.925 rs78932312 chr6:26194869 A/G cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg20203395 chr5:56204925 C5orf35 -0.56 -7.95 -0.4 2.99e-14 Coronary artery disease; LUSC cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg26384229 chr12:38710491 ALG10B 0.79 12.94 0.58 2.49e-31 Bladder cancer; LUSC cis rs7072216 0.763 rs2147900 chr10:100174721 T/C cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs7267979 1.000 rs2482930 chr20:25334115 G/C cg08601574 chr20:25228251 PYGB -0.45 -6.91 -0.35 2.43e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11756438 0.572 rs1844964 chr6:119002528 C/T cg21191810 chr6:118973309 C6orf204 0.34 5.88 0.31 9.9e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1448094 0.872 rs1026085 chr12:86355735 A/G cg00310523 chr12:86230176 RASSF9 0.38 6.82 0.35 4.32e-11 Major depressive disorder; LUSC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg03732007 chr1:2071316 PRKCZ -0.5 -8.73 -0.43 1.23e-16 Height; LUSC trans rs11088226 0.681 rs2833912 chr21:33949822 G/A cg09050820 chr6:167586206 TCP10L2 0.75 9.99 0.48 1.02e-20 Gastritis; LUSC cis rs789859 0.965 rs812583 chr3:194406505 C/G cg02072170 chr3:194406190 FAM43A 0.36 7.65 0.39 2.21e-13 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg26597838 chr10:835615 NA 0.86 11.69 0.54 1.07e-26 Eosinophil percentage of granulocytes; LUSC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg17515076 chr17:73810948 UNK -0.39 -6.64 -0.34 1.27e-10 White matter hyperintensity burden; LUSC cis rs4843747 0.671 rs13334603 chr16:88116016 T/C cg09044154 chr16:88155775 NA -0.55 -7.35 -0.37 1.55e-12 Menopause (age at onset); LUSC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg21918786 chr6:109611834 NA -0.4 -6.9 -0.35 2.59e-11 Reticulocyte fraction of red cells; LUSC cis rs12681287 0.640 rs7017706 chr8:87480890 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs9443645 0.509 rs9361459 chr6:79572922 A/G cg05283184 chr6:79620031 NA 0.52 10.52 0.5 1.49e-22 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.554 rs77194105 chr2:238436463 T/C cg14458575 chr2:238380390 NA 0.62 7.16 0.36 5.25e-12 Prostate cancer; LUSC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg20203395 chr5:56204925 C5orf35 0.68 9.3 0.45 1.89e-18 Initial pursuit acceleration; LUSC trans rs4332037 0.539 rs55790766 chr7:2021248 C/T cg11693508 chr17:37793320 STARD3 0.6 7.16 0.36 5.12e-12 Bipolar disorder; LUSC cis rs9326248 1.000 rs7107152 chr11:117056080 C/T cg15534755 chr11:117069859 TAGLN -0.35 -6.08 -0.32 3.35e-9 Blood protein levels; LUSC cis rs72634258 0.554 rs7556518 chr1:7847846 G/A cg26816564 chr1:7831052 VAMP3 0.98 13.48 0.59 2.29e-33 Inflammatory bowel disease; LUSC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg06873352 chr17:61820015 STRADA 0.56 8.68 0.43 1.83e-16 Height; LUSC cis rs68170813 0.559 rs12538769 chr7:106984288 C/T cg02696742 chr7:106810147 HBP1 -0.62 -9.31 -0.45 1.75e-18 Coronary artery disease; LUSC trans rs1728785 1.000 rs1728765 chr16:68589433 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.29 0.41 2.71e-15 Ulcerative colitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18815779 chr20:9819789 PAK7 -0.47 -6.5 -0.34 2.95e-10 Bipolar disorder and schizophrenia; LUSC cis rs7577851 0.715 rs7602427 chr2:69640145 G/A cg10773587 chr2:69614142 GFPT1 0.57 7.11 0.36 7.1e-12 Parkinson's disease (age of onset); LUSC cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs4925386 0.681 rs2427296 chr20:60927475 G/A cg06026331 chr20:60912101 LAMA5 0.55 6.65 0.34 1.21e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs7246657 0.943 rs10415024 chr19:37814724 A/G cg23950597 chr19:37808831 NA -0.65 -7.74 -0.39 1.17e-13 Coronary artery calcification; LUSC cis rs12791968 1.000 rs12791968 chr11:45001490 C/T cg11846598 chr11:44996168 LOC221122 0.73 11.79 0.54 4.55e-27 Inhibitory control; LUSC cis rs11105298 0.891 rs10858899 chr12:89923811 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.34 -0.37 1.69e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.44 0.53 8.42e-26 Menopause (age at onset); LUSC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg23172400 chr8:95962367 TP53INP1 -0.4 -7.92 -0.4 3.54e-14 Type 2 diabetes; LUSC cis rs983392 0.719 rs610932 chr11:59939307 T/G cg20284999 chr11:59952153 MS4A6A 0.35 6.11 0.32 2.85e-9 Alzheimer's disease (late onset); LUSC cis rs9472414 0.510 rs227857 chr6:44704392 A/T cg20913747 chr6:44695427 NA 0.39 5.85 0.3 1.18e-8 Height; LUSC cis rs17095355 1.000 rs7921609 chr10:111691599 G/A cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.3 -0.37 2.16e-12 Biliary atresia; LUSC cis rs3096299 0.967 rs3102341 chr16:89450744 G/A cg08392591 chr16:89556376 ANKRD11 0.39 5.82 0.3 1.38e-8 Multiple myeloma (IgH translocation); LUSC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs983392 0.679 rs672399 chr11:60020112 T/G cg24026212 chr11:59952134 MS4A6A 0.37 6.36 0.33 6.64e-10 Alzheimer's disease (late onset); LUSC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.63 0.65 1.03e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg15448220 chr1:150897856 SETDB1 0.44 6.43 0.33 4.41e-10 Melanoma; LUSC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg21138405 chr5:131827807 IRF1 0.54 10.09 0.48 4.63e-21 Asthma (sex interaction); LUSC cis rs9392556 0.829 rs7166 chr6:4116262 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.3 -0.33 9.22e-10 Blood metabolite levels; LUSC cis rs854765 0.583 rs8070722 chr17:17813562 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.19 0.59 2.99e-32 Total body bone mineral density; LUSC cis rs6542838 0.641 rs10192266 chr2:99521837 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.5 -0.34 2.95e-10 Fear of minor pain; LUSC cis rs2274273 0.662 rs67092614 chr14:55672055 G/A cg04306507 chr14:55594613 LGALS3 0.47 9.24 0.45 3.04e-18 Protein biomarker; LUSC trans rs3942852 0.910 rs10742829 chr11:48115837 C/T cg15704280 chr7:45808275 SEPT13 0.54 6.21 0.32 1.6e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs7180079 1.000 rs8034610 chr15:64628917 G/A cg08069370 chr15:64387884 SNX1 0.57 6.28 0.32 1.05e-9 Monocyte count; LUSC cis rs11098499 0.954 rs11940028 chr4:120411907 T/C cg09307838 chr4:120376055 NA 0.79 11.8 0.54 4.37e-27 Corneal astigmatism; LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg10802521 chr3:52805072 NEK4 -0.57 -8.97 -0.44 2.22e-17 Bipolar disorder; LUSC cis rs9303401 0.527 rs7224468 chr17:56749943 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.66 0.57 2.81e-30 Cognitive test performance; LUSC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.02 0.48 7.73e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9400467 0.528 rs12190634 chr6:111725160 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.98 -0.36 1.56e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs9914988 0.943 rs7211502 chr17:27163295 C/A cg14438399 chr17:27053147 TLCD1 0.53 5.84 0.3 1.22e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs12791968 0.765 rs12794751 chr11:44998769 C/G cg11846598 chr11:44996168 LOC221122 -0.62 -8.87 -0.44 4.52e-17 Inhibitory control; LUSC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg11764359 chr7:65958608 NA 0.7 10.66 0.5 5e-23 Aortic root size; LUSC cis rs8028313 0.731 rs4776964 chr15:68016955 T/G cg08079166 chr15:68083412 MAP2K5 0.36 6.22 0.32 1.51e-9 Obesity; LUSC cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg12310025 chr6:25882481 NA 0.61 10.17 0.49 2.33e-21 Blood metabolite levels; LUSC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg23711669 chr6:146136114 FBXO30 0.82 14.36 0.62 9.24e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg25427524 chr10:38739819 LOC399744 0.62 10.99 0.52 3.43e-24 Extrinsic epigenetic age acceleration; LUSC cis rs6964587 1.000 rs2301559 chr7:91746727 T/C cg17063962 chr7:91808500 NA 0.6 9.45 0.46 6.13e-19 Breast cancer; LUSC cis rs9430161 0.611 rs35033941 chr1:11034382 C/T cg27631724 chr1:11040367 C1orf127 0.54 9.4 0.46 8.69e-19 Ewing sarcoma; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg13560548 chr3:10150139 C3orf24 0.49 6.8 0.35 4.69e-11 Alzheimer's disease; LUSC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg11645453 chr3:52864694 ITIH4 -0.37 -7.78 -0.39 9.24e-14 Bipolar disorder; LUSC cis rs7267979 1.000 rs6107033 chr20:25363591 A/G cg08601574 chr20:25228251 PYGB -0.41 -6.3 -0.33 9.64e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7586879 1.000 rs12713419 chr2:25121853 G/A cg01884057 chr2:25150051 NA 0.43 9.37 0.46 1.1e-18 Body mass index; LUSC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg07234876 chr8:600039 NA -0.68 -5.94 -0.31 7.15e-9 IgG glycosylation; LUSC cis rs2439831 0.867 rs2927072 chr15:43922398 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.89 9.56 0.46 2.6e-19 Lung cancer in ever smokers; LUSC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg24675056 chr1:15929824 NA -0.47 -8.14 -0.41 8.1e-15 Systolic blood pressure; LUSC cis rs9649213 0.586 rs55648546 chr7:97960800 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.7 -9.93 -0.48 1.56e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs9513627 0.834 rs73556197 chr13:100128479 A/G cg25919922 chr13:100150906 NA -0.75 -6.44 -0.33 4.11e-10 Obesity-related traits; LUSC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.909 rs7681978 chr4:120383775 T/C cg25214090 chr10:38739885 LOC399744 0.57 8.42 0.42 1.14e-15 Corneal astigmatism; LUSC cis rs909341 0.859 rs2258056 chr20:62328453 T/C cg09650180 chr20:62225654 GMEB2 -0.45 -5.94 -0.31 7.04e-9 Atopic dermatitis; LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg00149659 chr3:10157352 C3orf10 0.94 12.49 0.56 1.18e-29 Alzheimer's disease; LUSC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.81 -0.35 4.42e-11 Menopause (age at onset); LUSC cis rs1538970 0.962 rs4660301 chr1:45820149 T/A cg05343316 chr1:45956843 TESK2 0.61 8.59 0.43 3.38e-16 Platelet count; LUSC cis rs4629180 0.675 rs4851459 chr2:102109006 T/A cg01388757 chr2:102091195 RFX8 -0.37 -6.37 -0.33 6.14e-10 Chronic rhinosinusitis with nasal polyps; LUSC trans rs2587949 0.593 rs1843303 chr3:4185124 T/C cg15139668 chr4:4577005 NA -0.42 -6.02 -0.31 4.64e-9 Periodontitis (DPAL); LUSC cis rs17095355 0.818 rs56367935 chr10:111783266 C/T cg00817464 chr10:111662876 XPNPEP1 -0.58 -6.72 -0.34 8.01e-11 Biliary atresia; LUSC cis rs7809950 1.000 rs2520277 chr7:107130234 C/T cg23024343 chr7:107201750 COG5 -0.55 -8.81 -0.43 7.13e-17 Coronary artery disease; LUSC cis rs9467773 0.933 rs35355150 chr6:26526039 G/A cg09904177 chr6:26538194 HMGN4 0.74 13.91 0.61 5.2e-35 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.863 rs6534141 chr4:120485223 A/T cg24375607 chr4:120327624 NA 0.74 10.89 0.51 7.53e-24 Corneal astigmatism; LUSC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg19622623 chr12:86230825 RASSF9 -0.45 -6.22 -0.32 1.53e-9 Major depressive disorder; LUSC cis rs9486715 0.793 rs2499777 chr6:97013814 T/C cg06623918 chr6:96969491 KIAA0776 -0.93 -17.6 -0.69 1.54e-49 Headache; LUSC cis rs7580658 0.750 rs6731176 chr2:128071003 C/T cg09760422 chr2:128146352 NA -0.29 -6.73 -0.35 7.45e-11 Protein C levels; LUSC cis rs11608355 0.597 rs7300290 chr12:109832545 T/G cg19025524 chr12:109796872 NA -0.46 -8.8 -0.43 7.27e-17 Neuroticism; LUSC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg14552801 chr7:65878734 NA -0.44 -6.38 -0.33 5.99e-10 Aortic root size; LUSC cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg14664628 chr15:75095509 CSK -0.57 -8.47 -0.42 8.13e-16 Breast cancer; LUSC cis rs4242434 0.672 rs3758042 chr8:22486951 T/C cg03733263 chr8:22462867 KIAA1967 0.77 12.42 0.56 2.29e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg21573476 chr21:45109991 RRP1B -0.38 -6.09 -0.32 3.17e-9 Mean corpuscular volume; LUSC cis rs56283067 0.578 rs62400353 chr6:45387899 G/A cg20913747 chr6:44695427 NA -0.42 -6.07 -0.32 3.56e-9 Total body bone mineral density; LUSC cis rs2404602 0.647 rs4886840 chr15:77179002 A/G cg23625390 chr15:77176239 SCAPER -0.65 -9.98 -0.48 1.09e-20 Blood metabolite levels; LUSC cis rs1577917 0.538 rs7755996 chr6:86423720 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.52 8.09 0.4 1.1e-14 Response to antipsychotic treatment; LUSC cis rs9513112 0.754 rs9513113 chr13:29007143 A/G cg22753668 chr13:29013387 FLT1 0.34 6.12 0.32 2.56e-9 Coronary artery disease; LUSC cis rs9951602 0.651 rs2959408 chr18:76681702 T/C cg00806245 chr18:76673096 NA 0.44 6.22 0.32 1.48e-9 Obesity-related traits; LUSC cis rs10791097 0.694 rs1893017 chr11:130756253 C/T cg12179176 chr11:130786555 SNX19 0.85 14.78 0.63 2.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4851254 0.584 rs56935201 chr2:100637788 G/A cg07810366 chr2:100720526 AFF3 -0.47 -5.98 -0.31 5.65e-9 Intelligence (multi-trait analysis); LUSC trans rs9650657 0.537 rs7016385 chr8:10779472 A/G cg06636001 chr8:8085503 FLJ10661 0.5 6.88 0.35 2.88e-11 Neuroticism; LUSC cis rs9549367 0.789 rs7994324 chr13:113906497 T/C cg18105134 chr13:113819100 PROZ -0.67 -9.57 -0.46 2.46e-19 Platelet distribution width; LUSC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg03605463 chr16:89740564 NA -0.38 -5.81 -0.3 1.47e-8 Vitiligo; LUSC cis rs2985684 1.000 rs11157696 chr14:50105746 C/G cg04989706 chr14:50066350 PPIL5 0.44 5.75 0.3 2.04e-8 Carotid intima media thickness; LUSC cis rs72717009 0.825 rs9427398 chr1:161476205 A/G cg23840854 chr1:161414152 NA -0.92 -11.15 -0.52 9.48e-25 Rheumatoid arthritis; LUSC cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg15549821 chr19:49342101 PLEKHA4 -0.52 -6.09 -0.32 3.13e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs2573652 0.723 rs2727201 chr15:100515311 A/G cg00587665 chr15:100533223 ADAMTS17 -0.36 -5.82 -0.3 1.37e-8 Height; LUSC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.07 -0.4 1.25e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg07701084 chr6:150067640 NUP43 0.58 8.92 0.44 3.05e-17 Lung cancer; LUSC cis rs7520050 0.778 rs2934857 chr1:46039612 A/G cg24296786 chr1:45957014 TESK2 -0.41 -5.7 -0.3 2.7e-8 Red blood cell count;Reticulocyte count; LUSC cis rs1215050 0.791 rs2865942 chr4:98737709 G/C cg05340658 chr4:99064831 C4orf37 0.43 6.87 0.35 3.2e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs754466 0.914 rs12218917 chr10:79701479 C/T cg17075019 chr10:79541650 NA -0.61 -7.96 -0.4 2.75e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg26384229 chr12:38710491 ALG10B 0.64 10.05 0.48 5.93e-21 Morning vs. evening chronotype; LUSC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg26597838 chr10:835615 NA -0.97 -13.38 -0.59 5.45e-33 Eosinophil percentage of granulocytes; LUSC cis rs4478858 0.735 rs6425736 chr1:31784376 T/A cg00250761 chr1:31883323 NA -0.34 -8.46 -0.42 8.22e-16 Alcohol dependence; LUSC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg25427524 chr10:38739819 LOC399744 -0.71 -13.32 -0.59 9.28e-33 Extrinsic epigenetic age acceleration; LUSC cis rs2580764 0.516 rs2860453 chr2:55270485 T/G cg20993754 chr2:55226987 RTN4 -0.36 -5.97 -0.31 5.96e-9 Mean platelet volume; LUSC cis rs9534288 0.956 rs962694 chr13:46619026 T/C cg15192986 chr13:46630673 CPB2 -0.74 -11.41 -0.53 1.1e-25 Blood protein levels; LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg21782813 chr7:2030301 MAD1L1 0.57 10.27 0.49 1.06e-21 Bipolar disorder and schizophrenia; LUSC cis rs8062405 1.000 rs62036622 chr16:28837203 T/G cg09754948 chr16:28834200 ATXN2L 0.43 6.3 0.33 9.33e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.510 rs56241316 chr1:152901748 A/G cg00922841 chr1:152955080 SPRR1A -0.37 -6.01 -0.31 4.92e-9 Inflammatory skin disease; LUSC cis rs5769707 0.732 rs135865 chr22:50004829 G/A cg05373962 chr22:49881684 NA -0.4 -8.73 -0.43 1.24e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7216064 1.000 rs2365764 chr17:65857714 G/A cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs597583 0.951 rs579239 chr11:117425009 T/C cg27161313 chr11:117392002 DSCAML1 -0.4 -7.05 -0.36 1.02e-11 Putamen volume; LUSC cis rs62400317 0.859 rs11964690 chr6:45258068 A/G cg18551225 chr6:44695536 NA -0.39 -6.48 -0.33 3.39e-10 Total body bone mineral density; LUSC trans rs561341 1.000 rs576985 chr17:30323323 C/T cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs2762353 0.904 rs13197601 chr6:25785935 G/A cg03517284 chr6:25882590 NA 0.44 7.78 0.39 9.2e-14 Blood metabolite levels; LUSC cis rs4660306 0.672 rs532639 chr1:46024481 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.03 -0.31 4.3e-9 Homocysteine levels; LUSC cis rs2996428 0.667 rs11576900 chr1:3770914 A/G cg22529645 chr1:3704559 LRRC47 0.34 6.03 0.31 4.27e-9 Red cell distribution width; LUSC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg17971929 chr21:40555470 PSMG1 0.8 13.95 0.61 3.66e-35 Cognitive function; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg12516959 chr21:47718080 NA 0.36 5.99 0.31 5.43e-9 Testicular germ cell tumor; LUSC cis rs929596 0.785 rs6747843 chr2:234664354 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.7 -12.08 -0.55 4.14e-28 Total bilirubin levels in HIV-1 infection; LUSC cis rs9650315 0.866 rs13260033 chr8:57194966 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.62 0.34 1.39e-10 Height; LUSC cis rs367943 1.000 rs348928 chr5:112815295 C/T cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs3820068 0.532 rs1547034 chr1:15919049 T/A cg17385448 chr1:15911702 AGMAT 0.34 5.88 0.31 9.88e-9 Systolic blood pressure; LUSC trans rs6502050 0.835 rs6502069 chr17:80112599 G/T cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.45 6.0 0.31 5.14e-9 Renal function-related traits (BUN); LUSC cis rs1448094 0.872 rs4919777 chr12:86358491 C/T cg18827107 chr12:86230957 RASSF9 -0.39 -5.68 -0.3 2.9e-8 Major depressive disorder; LUSC cis rs11190604 1.000 rs11190604 chr10:102302457 A/G cg23241863 chr10:102295624 HIF1AN 0.49 5.94 0.31 7.05e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 11.6 0.54 2.36e-26 Hip circumference adjusted for BMI; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg00166722 chr3:10149974 C3orf24 0.61 8.66 0.43 2.1e-16 Alzheimer's disease; LUSC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg24675658 chr1:53192096 ZYG11B -0.55 -8.44 -0.42 9.6e-16 Monocyte count; LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg11645453 chr3:52864694 ITIH4 0.35 8.15 0.41 7.34e-15 Bipolar disorder; LUSC cis rs10089 1.000 rs13357268 chr5:127423051 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.22 0.56 1.26e-28 Ileal carcinoids; LUSC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg25456477 chr12:86230367 RASSF9 -0.42 -7.57 -0.38 3.72e-13 Major depressive disorder; LUSC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg06505273 chr16:24850292 NA -0.4 -5.76 -0.3 1.91e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs950169 0.614 rs765524 chr15:84681782 G/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.07 0.32 3.44e-9 Schizophrenia; LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg26338869 chr17:61819248 STRADA -0.43 -6.18 -0.32 1.83e-9 Prudent dietary pattern; LUSC cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg13010199 chr12:38710504 ALG10B 0.63 9.74 0.47 6.66e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs3764021 0.870 rs7970116 chr12:9880114 C/T cg20894963 chr12:9885564 CLECL1 -0.33 -6.68 -0.34 9.76e-11 Type 1 diabetes; LUSC cis rs4363385 0.693 rs6656812 chr1:152930254 C/T cg00922841 chr1:152955080 SPRR1A 0.41 6.93 0.35 2.16e-11 Inflammatory skin disease; LUSC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg24399712 chr22:39784796 NA -0.61 -10.22 -0.49 1.6e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs12681288 0.676 rs7459467 chr8:999359 C/T cg04851639 chr8:1020857 NA -0.37 -7.44 -0.38 8.56e-13 Schizophrenia; LUSC cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg26384229 chr12:38710491 ALG10B -0.93 -17.81 -0.7 2.46e-50 Heart rate; LUSC cis rs12928939 0.911 rs8051878 chr16:71818431 C/G cg03805757 chr16:71968109 PKD1L3 -0.46 -6.65 -0.34 1.23e-10 Post bronchodilator FEV1; LUSC cis rs1865760 0.625 rs9393681 chr6:26008260 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.95 0.36 1.96e-11 Height; LUSC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg15110403 chr19:17392923 ANKLE1 -0.59 -8.02 -0.4 1.85e-14 Systemic lupus erythematosus; LUSC cis rs7833986 0.501 rs72653962 chr8:56997505 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.25 0.56 9.52e-29 Height; LUSC trans rs3749237 1.000 rs11710675 chr3:49751900 C/A cg21659725 chr3:3221576 CRBN 0.64 9.39 0.46 9.3e-19 Resting heart rate; LUSC trans rs62103177 0.810 rs62103194 chr18:77629482 G/A cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC cis rs7712401 0.755 rs10071705 chr5:122132725 T/C cg19077854 chr5:122220652 SNX24 0.34 7.71 0.39 1.49e-13 Mean platelet volume; LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 7.84e-17 Prudent dietary pattern; LUSC cis rs9303280 0.617 rs6503525 chr17:38095174 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.36 6.05 0.31 3.95e-9 Self-reported allergy; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg27535305 chr1:53392650 SCP2 -0.39 -7.48 -0.38 6.64e-13 Monocyte count; LUSC cis rs765787 0.530 rs12910270 chr15:45512086 G/A cg24006582 chr15:45444508 DUOX1 0.66 9.6 0.47 1.92e-19 Uric acid levels; LUSC cis rs55665837 1.000 rs10832268 chr11:14465068 C/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.54 -0.38 4.47e-13 Vitamin D levels; LUSC cis rs968567 0.705 rs174575 chr11:61602003 C/G cg06781209 chr11:61594997 FADS2 -0.42 -6.95 -0.36 1.88e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -7.84 -0.39 6.21e-14 Personality dimensions; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg10802521 chr3:52805072 NEK4 -0.41 -6.47 -0.33 3.48e-10 Electroencephalogram traits; LUSC cis rs1030877 0.515 rs2576736 chr2:105890971 C/T cg02079111 chr2:105885981 TGFBRAP1 0.65 8.65 0.43 2.25e-16 Obesity-related traits; LUSC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg19717773 chr7:2847554 GNA12 -0.39 -6.19 -0.32 1.78e-9 Height; LUSC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg17252645 chr8:143867129 LY6D 0.38 6.65 0.34 1.21e-10 Urinary tract infection frequency; LUSC cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg05347473 chr6:146136440 FBXO30 -0.48 -7.98 -0.4 2.41e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg18252515 chr7:66147081 NA -0.89 -9.91 -0.48 1.85e-20 Diabetic kidney disease; LUSC cis rs7177699 0.550 rs7182103 chr15:79123946 G/T cg15571903 chr15:79123663 NA 0.34 6.32 0.33 8.21e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10193935 0.901 rs12622153 chr2:42598386 C/A cg27598129 chr2:42591480 NA -0.65 -8.73 -0.43 1.21e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs4803468 1.000 rs2304242 chr19:41944616 G/T cg09537434 chr19:41945824 ATP5SL 0.93 15.95 0.66 5.75e-43 Height; LUSC cis rs425277 0.561 rs11584491 chr1:2042543 A/G cg13918804 chr1:2043761 PRKCZ 0.27 5.78 0.3 1.75e-8 Height; LUSC cis rs5758659 0.737 rs10854749 chr22:42447341 G/T cg15557168 chr22:42548783 NA -0.41 -7.16 -0.36 5.21e-12 Cognitive function; LUSC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg14440974 chr22:39074834 NA -0.38 -6.32 -0.33 8.52e-10 Menopause (age at onset); LUSC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg07507251 chr3:52567010 NT5DC2 0.32 5.91 0.31 8.59e-9 Bipolar disorder; LUSC cis rs3931020 0.657 rs7522428 chr1:75178360 C/T cg21906852 chr1:75198582 TYW3;CRYZ 0.45 5.87 0.31 1.07e-8 Resistin levels; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg22166914 chr1:53195759 ZYG11B 0.61 10.29 0.49 9.15e-22 Monocyte count; LUSC cis rs4803468 1.000 rs284651 chr19:41928336 T/C cg09537434 chr19:41945824 ATP5SL -0.92 -15.87 -0.66 1.12e-42 Height; LUSC cis rs7267979 0.844 rs6076343 chr20:25376663 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.79 -16.62 -0.67 1.28e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9341808 0.667 rs2490239 chr6:80826289 G/A cg08355045 chr6:80787529 NA 0.49 8.44 0.42 9.45e-16 Sitting height ratio; LUSC cis rs2580764 0.598 rs7340476 chr2:55227346 G/C cg20993754 chr2:55226987 RTN4 0.34 5.69 0.3 2.82e-8 Mean platelet volume; LUSC cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.86 0.4 5.28e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2797160 1.000 rs1832979 chr6:125997436 A/G cg05901451 chr6:126070800 HEY2 -0.59 -8.96 -0.44 2.28e-17 Endometrial cancer; LUSC trans rs2839186 0.869 rs17176513 chr21:47682428 A/G cg10388307 chr1:82828058 NA 0.39 6.13 0.32 2.44e-9 Testicular germ cell tumor; LUSC cis rs8060686 0.641 rs12448677 chr16:68209741 G/A cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs225245 0.817 rs12150359 chr17:34024584 C/T cg19694781 chr19:47549865 TMEM160 -0.38 -6.17 -0.32 1.95e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg12463550 chr7:65579703 CRCP -0.52 -7.52 -0.38 4.96e-13 Aortic root size; LUSC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg16240275 chr20:61666158 NCRNA00029 -0.42 -8.97 -0.44 2.09e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs72772090 0.710 rs17400685 chr5:96066366 A/C cg17330273 chr5:96107758 CAST;ERAP1 0.59 6.65 0.34 1.2e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg13852791 chr20:30311386 BCL2L1 0.85 11.15 0.52 9.59e-25 Mean corpuscular hemoglobin; LUSC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg18196295 chr10:418757 DIP2C 0.41 6.69 0.34 9.62e-11 Psychosis in Alzheimer's disease; LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.86 0.63 1.06e-38 Platelet count; LUSC trans rs3942852 1.000 rs3942852 chr11:48115089 C/T cg15704280 chr7:45808275 SEPT13 -0.54 -6.24 -0.32 1.3e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs4242434 0.672 rs3758041 chr8:22486987 A/G cg03733263 chr8:22462867 KIAA1967 0.77 12.42 0.56 2.29e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg24733560 chr20:60626293 TAF4 0.35 6.04 0.31 4.22e-9 Body mass index; LUSC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg06951627 chr6:26196580 NA 0.55 5.94 0.31 7.14e-9 Gout;Renal underexcretion gout; LUSC cis rs9329221 0.905 rs28507213 chr8:10250849 C/T cg27411982 chr8:10470053 RP1L1 -0.5 -7.82 -0.39 6.76e-14 Neuroticism; LUSC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg09165964 chr15:75287851 SCAMP5 -1.01 -15.29 -0.64 2.16e-40 Blood trace element (Zn levels); LUSC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.88 0.4 4.65e-14 Bipolar disorder; LUSC cis rs2404602 0.655 rs4886507 chr15:77209694 T/C cg22467129 chr15:76604101 ETFA -0.43 -6.74 -0.35 6.89e-11 Blood metabolite levels; LUSC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg02569458 chr12:86230093 RASSF9 0.51 8.53 0.42 5.01e-16 Major depressive disorder; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg14893161 chr1:205819251 PM20D1 -0.78 -15.71 -0.65 4.85e-42 Monocyte percentage of white cells; LUSC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.13e-12 Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08548086 chr5:73980929 HEXB 0.45 6.16 0.32 2.14e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg21665744 chr7:39171113 POU6F2 0.48 7.86 0.4 5.38e-14 IgG glycosylation; LUSC trans rs2055729 0.813 rs55999429 chr8:9741185 G/C cg15556689 chr8:8085844 FLJ10661 -0.49 -6.58 -0.34 1.81e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs11098499 0.863 rs10018280 chr4:120478139 T/G cg09307838 chr4:120376055 NA 0.76 11.15 0.52 8.96e-25 Corneal astigmatism; LUSC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg26380479 chr7:97908229 NA 0.28 6.3 0.33 9.49e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg16049864 chr8:95962084 TP53INP1 -0.72 -14.25 -0.61 2.59e-36 Type 2 diabetes; LUSC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg09323728 chr8:95962352 TP53INP1 -0.41 -8.63 -0.43 2.53e-16 Type 2 diabetes; LUSC cis rs1048238 0.506 rs7547314 chr1:16186722 G/A cg22431228 chr1:16359049 CLCNKA -0.4 -8.38 -0.42 1.45e-15 Systolic blood pressure; LUSC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg01943577 chr7:158741284 NA -0.4 -5.79 -0.3 1.62e-8 Height; LUSC cis rs7582180 0.764 rs4851293 chr2:100925106 A/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.44 -0.42 9.64e-16 Intelligence (multi-trait analysis); LUSC cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg15423357 chr2:25149977 NA -0.4 -8.05 -0.4 1.5e-14 Body mass index; LUSC cis rs2303282 0.933 rs14306 chr16:56510299 A/C cg00500540 chr16:56394104 NA -0.44 -7.04 -0.36 1.09e-11 Breast cancer; LUSC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg23711669 chr6:146136114 FBXO30 0.88 15.9 0.66 8.82e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 9.07 0.44 1.01e-17 Hip circumference adjusted for BMI; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg09704166 chr2:114031854 PAX8;LOC440839 0.47 8.07 0.4 1.26e-14 Lymphocyte counts; LUSC cis rs7914558 0.902 rs3736922 chr10:104850632 A/G cg04362960 chr10:104952993 NT5C2 -0.49 -7.44 -0.38 8.41e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg18876405 chr7:65276391 NA -0.55 -8.76 -0.43 9.78e-17 Aortic root size; LUSC cis rs9837602 0.938 rs9828079 chr3:99806645 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -5.71 -0.3 2.49e-8 Breast cancer; LUSC cis rs13385 0.769 rs2291878 chr5:139539514 A/G cg26211634 chr5:139558579 C5orf32 0.38 5.75 0.3 1.99e-8 Atrial fibrillation; LUSC cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg06505273 chr16:24850292 NA -0.43 -6.37 -0.33 6.41e-10 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg01657329 chr11:68192670 LRP5 -0.42 -6.3 -0.33 9.42e-10 Total body bone mineral density; LUSC trans rs9650657 0.707 rs10098699 chr8:10676756 C/T cg15556689 chr8:8085844 FLJ10661 -0.4 -6.01 -0.31 4.95e-9 Neuroticism; LUSC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg04414720 chr1:150670196 GOLPH3L 0.51 8.12 0.41 9.37e-15 Melanoma; LUSC cis rs11158026 0.603 rs4325453 chr14:55439318 G/A cg04306507 chr14:55594613 LGALS3 0.4 7.44 0.38 8.33e-13 Parkinson's disease; LUSC cis rs9341808 0.667 rs742833 chr6:80921446 C/T cg08355045 chr6:80787529 NA 0.46 7.77 0.39 9.69e-14 Sitting height ratio; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg27094323 chr7:1216898 NA -0.35 -6.07 -0.32 3.43e-9 Longevity;Endometriosis; LUSC cis rs1568889 1.000 rs12797712 chr11:28290890 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 8.79 0.43 7.85e-17 Bipolar disorder; LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs1298062 0.605 rs10409679 chr19:50983930 C/T cg11430371 chr19:50961752 MYBPC2 0.29 5.74 0.3 2.12e-8 Age of smoking initiation; LUSC cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg16482183 chr6:26056742 HIST1H1C 0.44 6.44 0.33 4.13e-10 Intelligence (multi-trait analysis); LUSC cis rs10208940 0.764 rs34744266 chr2:68782606 G/A cg12452813 chr2:68675892 NA 0.56 5.81 0.3 1.45e-8 Urate levels in lean individuals; LUSC cis rs2073300 0.609 rs6137945 chr20:23406136 C/T cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs877282 0.583 rs11253428 chr10:823233 C/T cg13775593 chr10:823151 NA 0.31 6.06 0.31 3.75e-9 Uric acid levels; LUSC cis rs4595586 0.545 rs1562728 chr12:39405740 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.16 0.32 2.05e-9 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs854765 0.547 rs2955378 chr17:17930253 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.82 15.56 0.65 1.93e-41 Total body bone mineral density; LUSC cis rs79349575 0.783 rs4255820 chr17:46996583 T/A cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.31e-13 Type 2 diabetes; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg18099408 chr3:52552593 STAB1 -0.39 -6.28 -0.32 1.07e-9 Bipolar disorder; LUSC trans rs3942852 0.703 rs11039513 chr11:48107204 C/T cg03929089 chr4:120376271 NA 0.6 7.35 0.37 1.59e-12 Acute lymphoblastic leukemia (childhood); LUSC trans rs11098499 0.908 rs11098527 chr4:120399906 A/G cg25214090 chr10:38739885 LOC399744 0.55 7.98 0.4 2.3e-14 Corneal astigmatism; LUSC cis rs66573146 0.656 rs41410847 chr4:6957332 C/T cg02503808 chr4:7069936 GRPEL1 -0.68 -6.14 -0.32 2.35e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6456156 0.586 rs12213801 chr6:167474084 T/A cg06454157 chr6:167490870 NA -0.27 -6.65 -0.34 1.22e-10 Primary biliary cholangitis; LUSC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.74 -0.35 7.05e-11 Lung cancer; LUSC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg11663144 chr21:46675770 NA -0.37 -6.07 -0.32 3.52e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg09021430 chr5:549028 NA -0.57 -7.7 -0.39 1.61e-13 Obesity-related traits; LUSC cis rs1461503 0.934 rs7107560 chr11:122845380 T/C cg27398637 chr11:122830231 C11orf63 -0.41 -6.57 -0.34 1.98e-10 Menarche (age at onset); LUSC cis rs9325144 0.560 rs11182979 chr12:38642562 C/A cg13010199 chr12:38710504 ALG10B -0.51 -7.72 -0.39 1.36e-13 Morning vs. evening chronotype; LUSC cis rs4343996 0.902 rs4719894 chr7:3381789 C/T cg21248987 chr7:3385318 SDK1 -0.41 -7.1 -0.36 7.44e-12 Motion sickness; LUSC cis rs1018836 0.886 rs12545351 chr8:91636668 C/T cg16814680 chr8:91681699 NA -0.78 -13.01 -0.58 1.39e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg08847533 chr14:75593920 NEK9 -0.8 -13.65 -0.6 5.02e-34 Height; LUSC cis rs7605827 0.930 rs6431695 chr2:15539816 T/C cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs977987 0.872 rs7206665 chr16:75475287 A/C cg04384234 chr16:75411784 CFDP1 -0.45 -7.54 -0.38 4.62e-13 Dupuytren's disease; LUSC cis rs6693567 0.565 rs4926422 chr1:150315436 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.02 0.36 1.22e-11 Migraine; LUSC cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg23711669 chr6:146136114 FBXO30 0.82 14.47 0.62 3.41e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs3540 0.512 rs3862434 chr15:91080387 C/T cg10434728 chr15:90938212 IQGAP1 0.44 9.1 0.45 8.45e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12410462 0.681 rs75876430 chr1:227661157 A/G cg23173402 chr1:227635558 NA 0.77 8.13 0.41 8.58e-15 Major depressive disorder; LUSC cis rs10489202 1.000 rs2420 chr1:167886502 A/T cg24449463 chr1:168025552 DCAF6 -0.55 -6.67 -0.34 1.04e-10 Schizophrenia; LUSC cis rs911555 0.574 rs34251103 chr14:103860063 A/G cg24130564 chr14:104152367 KLC1 0.43 6.15 0.32 2.22e-9 Intelligence (multi-trait analysis); LUSC cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg03517284 chr6:25882590 NA -0.51 -9.58 -0.46 2.35e-19 Blood metabolite levels; LUSC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.79 0.47 4.77e-20 Personality dimensions; LUSC cis rs9322817 0.691 rs9377679 chr6:105345036 C/T cg02098413 chr6:105308735 HACE1 0.28 5.96 0.31 6.43e-9 Thyroid stimulating hormone; LUSC cis rs7709377 0.595 rs253952 chr5:115633670 A/G cg23108291 chr5:115420582 COMMD10 -0.41 -5.66 -0.3 3.34e-8 Metabolite levels (X-11787); LUSC cis rs11608355 0.515 rs12818537 chr12:109902150 C/T cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg12432903 chr7:1882776 MAD1L1 -0.39 -6.28 -0.32 1.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs950169 0.763 rs35372971 chr15:84941795 G/A cg12863693 chr15:85201151 NMB 0.35 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs859767 0.672 rs10203582 chr2:135362839 C/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.44 -0.33 4.17e-10 Neuroticism; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg17554472 chr22:41940697 POLR3H -0.47 -5.67 -0.3 3.13e-8 Vitiligo; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs3806843 1.000 rs6898939 chr5:140169355 C/A cg26395211 chr5:140044315 WDR55 -0.39 -5.99 -0.31 5.32e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg13393036 chr8:95962371 TP53INP1 -0.52 -11.05 -0.52 2.05e-24 Type 2 diabetes; LUSC cis rs6700896 0.500 rs4655566 chr1:66088951 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.54 6.31 0.33 8.83e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26149032 chr3:158519514 MFSD1 0.51 6.47 0.33 3.54e-10 Intelligence (multi-trait analysis); LUSC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg20607287 chr7:12443886 VWDE -0.57 -6.03 -0.31 4.43e-9 Coronary artery disease; LUSC cis rs1965732 0.958 rs6755529 chr2:3711972 C/T cg00999904 chr2:3704751 ALLC 0.32 5.86 0.31 1.13e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg02175503 chr12:58329896 NA 0.51 7.31 0.37 1.96e-12 Intelligence (multi-trait analysis); LUSC cis rs9905704 0.718 rs1271647 chr17:56655872 G/C cg12560992 chr17:57184187 TRIM37 -0.51 -5.91 -0.31 8.67e-9 Testicular germ cell tumor; LUSC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg04362960 chr10:104952993 NT5C2 0.59 8.86 0.44 4.75e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs28374715 0.662 rs1554445 chr15:41503198 A/C cg18705301 chr15:41695430 NDUFAF1 -0.84 -14.43 -0.62 4.99e-37 Ulcerative colitis; LUSC cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg06784218 chr1:46089804 CCDC17 -0.48 -9.23 -0.45 3.17e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3008870 0.755 rs1024229 chr1:67512903 G/T cg02640540 chr1:67518911 SLC35D1 0.55 7.83 0.39 6.41e-14 Lymphocyte percentage of white cells; LUSC cis rs2285947 1.000 rs2285947 chr7:21584088 A/G cg04471919 chr7:21584483 DNAH11 -0.34 -7.86 -0.4 5.28e-14 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs12681287 0.640 rs4490816 chr8:87384938 T/C cg27223183 chr8:87520930 FAM82B 0.55 7.37 0.37 1.37e-12 Caudate activity during reward; LUSC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.56e-11 Total body bone mineral density; LUSC trans rs9650657 0.836 rs1073913 chr8:10611708 A/C cg15556689 chr8:8085844 FLJ10661 -0.4 -5.99 -0.31 5.31e-9 Neuroticism; LUSC cis rs7572644 0.640 rs4666015 chr2:28019367 G/A cg27432699 chr2:27873401 GPN1 0.55 7.26 0.37 2.74e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs735860 0.726 rs209490 chr6:53179047 C/T cg10236188 chr6:53219634 NA 0.37 5.67 0.3 3.15e-8 Glaucoma; LUSC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7824557 0.843 rs2736375 chr8:11115749 C/T cg21775007 chr8:11205619 TDH -0.58 -8.89 -0.44 3.95e-17 Retinal vascular caliber; LUSC cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg22676075 chr6:135203613 NA -0.46 -7.19 -0.37 4.25e-12 Red blood cell count; LUSC cis rs11711311 0.955 rs78029398 chr3:113421321 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.83 0.35 4.12e-11 IgG glycosylation; LUSC cis rs4280164 0.551 rs882726 chr14:24797997 C/A cg16194253 chr14:24768981 DHRS1;C14orf21 -0.62 -7.65 -0.39 2.15e-13 Parent of origin effect on language impairment (paternal); LUSC cis rs897080 0.552 rs1067378 chr2:44648047 A/G cg00619915 chr2:44497795 NA -0.42 -6.03 -0.31 4.26e-9 Height; LUSC trans rs8072100 0.967 rs8072644 chr17:45653364 A/T cg04995722 chr7:26192034 NFE2L3 0.37 6.07 0.32 3.54e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3931020 0.671 rs1327088 chr1:75255491 A/G cg21535942 chr1:75199100 CRYZ;TYW3 0.43 6.63 0.34 1.34e-10 Resistin levels; LUSC cis rs568617 0.953 rs645900 chr11:65648135 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.51 -6.15 -0.32 2.15e-9 Crohn's disease; LUSC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.55 8.42 0.42 1.09e-15 Menarche (age at onset); LUSC cis rs2832077 1.000 rs9983229 chr21:30137674 A/G cg24692254 chr21:30365293 RNF160 0.54 6.83 0.35 4.1e-11 Cognitive test performance; LUSC cis rs174479 0.677 rs174456 chr11:61656182 G/T cg01500311 chr11:61656094 FADS3 0.41 7.32 0.37 1.87e-12 Sphingolipid levels; LUSC cis rs7804356 1.000 rs6461979 chr7:26888918 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.11e-9 Type 1 diabetes; LUSC cis rs16912285 0.685 rs16912402 chr11:24313135 C/G ch.11.24196551F chr11:24239977 NA 0.71 5.87 0.31 1.08e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs61931739 0.517 rs11052980 chr12:34036036 T/C cg06521331 chr12:34319734 NA -0.49 -8.19 -0.41 5.73e-15 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24779145 chr19:40030822 EID2 -0.42 -6.3 -0.33 9.61e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7192380 0.571 rs10852456 chr16:69605613 G/T cg26679644 chr16:69762563 NA 0.35 6.17 0.32 1.94e-9 Sjögren's syndrome; LUSC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.07 15.41 0.64 7.55e-41 Age-related macular degeneration (geographic atrophy); LUSC cis rs9807989 0.811 rs4485584 chr2:102970750 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg02951883 chr7:2050386 MAD1L1 0.4 6.86 0.35 3.35e-11 Bipolar disorder and schizophrenia; LUSC cis rs5758659 0.967 rs5758670 chr22:42636687 T/C cg15557168 chr22:42548783 NA -0.43 -7.15 -0.36 5.57e-12 Cognitive function; LUSC trans rs2392780 0.667 rs432470 chr8:128339044 C/T cg10897648 chr18:56338258 MALT1 -0.44 -6.6 -0.34 1.59e-10 Breast cancer (early onset); LUSC cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg08807101 chr21:30365312 RNF160 -0.74 -13.06 -0.58 9e-32 Dental caries; LUSC cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg23711669 chr6:146136114 FBXO30 0.72 12.46 0.56 1.59e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs17828380 0.920 rs8025816 chr15:63448554 C/G cg05507819 chr15:63340323 TPM1 -0.78 -5.91 -0.31 8.37e-9 Social communication problems; LUSC cis rs4953076 0.573 rs6726680 chr2:44406686 C/G cg04920474 chr2:44395004 PPM1B 0.69 8.86 0.44 4.83e-17 Height; LUSC cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg09035930 chr12:129282057 SLC15A4 0.75 15.94 0.66 6.21e-43 Systemic lupus erythematosus; LUSC cis rs7605827 0.930 rs1990754 chr2:15615910 A/G cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs7647973 1.000 rs62259933 chr3:49469703 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.5 -7.57 -0.38 3.65e-13 Menarche (age at onset); LUSC trans rs6951245 1.000 rs79683221 chr7:1096139 A/G cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg22823121 chr1:150693482 HORMAD1 0.58 8.85 0.44 5.37e-17 Blood protein levels; LUSC cis rs6547741 0.935 rs6547738 chr2:27852637 A/G cg12559939 chr2:27858050 GPN1 0.38 5.95 0.31 6.89e-9 Oral cavity cancer; LUSC cis rs4654899 0.865 rs6664532 chr1:21515800 G/A cg02927042 chr1:21476669 EIF4G3 -0.39 -6.23 -0.32 1.4e-9 Superior frontal gyrus grey matter volume; LUSC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg18230493 chr5:56204884 C5orf35 -0.8 -12.52 -0.57 9.31e-30 Initial pursuit acceleration; LUSC cis rs4363385 0.747 rs2339490 chr1:152984612 A/G cg00922841 chr1:152955080 SPRR1A 0.38 6.6 0.34 1.66e-10 Inflammatory skin disease; LUSC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg06618935 chr21:46677482 NA -0.38 -7.55 -0.38 4.33e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9650657 0.513 rs4841459 chr8:10782442 A/C cg21775007 chr8:11205619 TDH -0.48 -6.76 -0.35 6.19e-11 Neuroticism; LUSC cis rs2439831 1.000 rs2467743 chr15:43750346 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg12647142 chr7:26240901 CBX3;HNRNPA2B1 0.4 6.22 0.32 1.51e-9 Schizophrenia; LUSC cis rs4363385 0.588 rs12082627 chr1:153023650 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.8 -0.3 1.54e-8 Inflammatory skin disease; LUSC cis rs950169 0.922 rs12915832 chr15:85111457 C/T cg17507749 chr15:85114479 UBE2QP1 0.69 9.15 0.45 5.91e-18 Schizophrenia; LUSC cis rs4601821 0.823 rs4938015 chr11:113264644 C/T cg14159747 chr11:113255604 NA -0.25 -6.04 -0.31 4.15e-9 Alcoholic chronic pancreatitis; LUSC cis rs3806843 1.000 rs10050455 chr5:140204650 A/G cg19875535 chr5:140030758 IK 0.51 8.25 0.41 3.64e-15 Depressive symptoms (multi-trait analysis); LUSC trans rs931812 1.000 rs4734494 chr8:101917721 T/C cg20993868 chr7:22813445 NA 0.57 10.46 0.5 2.43e-22 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.98 0.31 5.84e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg13395646 chr4:1353034 KIAA1530 -0.57 -8.53 -0.42 5.02e-16 Longevity; LUSC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg12963246 chr6:28129442 ZNF389 0.55 8.17 0.41 6.55e-15 Parkinson's disease; LUSC cis rs2439831 0.867 rs12324572 chr15:43636200 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 4.03e-19 Lung cancer in ever smokers; LUSC cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg15309053 chr8:964076 NA 0.38 7.72 0.39 1.4e-13 Schizophrenia; LUSC trans rs2797160 1.000 rs4897153 chr6:126003403 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.74 -0.35 6.9e-11 Endometrial cancer; LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg20887711 chr4:1340912 KIAA1530 0.47 7.22 0.37 3.42e-12 Obesity-related traits; LUSC trans rs2739330 0.789 rs5760109 chr22:24252938 C/G cg06437703 chr8:37914619 EIF4EBP1 -0.55 -8.5 -0.42 6.19e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg20398880 chr6:41068722 NFYA;LOC221442 0.39 6.04 0.31 4.18e-9 Alzheimer's disease (late onset); LUSC cis rs7605827 0.930 rs6759785 chr2:15529269 A/C cg19274914 chr2:15703543 NA 0.46 8.93 0.44 3.01e-17 Educational attainment (years of education); LUSC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg05585544 chr11:47624801 NA -0.42 -7.27 -0.37 2.64e-12 Subjective well-being; LUSC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -5.88 -0.31 9.82e-9 Life satisfaction; LUSC cis rs2840044 1.000 rs225295 chr17:33925755 A/G cg05299278 chr17:33885742 SLFN14 0.3 6.28 0.33 1.05e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs540254 0.578 rs3817407 chr1:160788131 T/C cg20255094 chr1:160771763 LY9 0.49 6.22 0.32 1.47e-9 Blood protein levels; LUSC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg12257692 chr3:49977190 RBM6 0.24 6.62 0.34 1.39e-10 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.500 rs11053290 chr12:34582392 C/T cg26384229 chr12:38710491 ALG10B -0.78 -13.29 -0.59 1.25e-32 Morning vs. evening chronotype; LUSC cis rs3806843 0.966 rs2563255 chr5:140142547 T/C cg19875535 chr5:140030758 IK -0.48 -7.72 -0.39 1.34e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.64 -0.3 3.56e-8 Life satisfaction; LUSC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg20849893 chr7:64541193 NA -0.65 -5.68 -0.3 2.99e-8 Diabetic kidney disease; LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg09436375 chr6:42928200 GNMT -0.28 -6.35 -0.33 6.84e-10 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg15704280 chr7:45808275 SEPT13 0.55 6.81 0.35 4.55e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg18404041 chr3:52824283 ITIH1 -0.61 -11.95 -0.55 1.16e-27 Bipolar disorder; LUSC trans rs724744 0.772 rs1772076 chr6:22352957 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.2 -0.32 1.71e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs6570726 0.526 rs72994723 chr6:145722948 G/A cg23711669 chr6:146136114 FBXO30 -0.49 -7.37 -0.37 1.38e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7945705 0.791 rs7944560 chr11:8817276 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.41 7.17 0.37 4.88e-12 Hemoglobin concentration; LUSC cis rs11122272 0.735 rs2808604 chr1:231538916 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.3 -0.49 8.36e-22 Hemoglobin concentration; LUSC cis rs1577917 0.771 rs9362233 chr6:86358247 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.94 -0.51 5.23e-24 Response to antipsychotic treatment; LUSC cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.77 0.35 5.84e-11 Rheumatoid arthritis; LUSC trans rs12200782 1.000 rs72844496 chr6:26611608 G/A cg11837749 chr1:55047332 ACOT11 0.57 5.98 0.31 5.64e-9 Small cell lung carcinoma; LUSC cis rs151349 1.000 rs151346 chr20:57587040 C/A cg23907860 chr20:57583709 CTSZ -0.47 -7.66 -0.39 2.08e-13 Platelet distribution width; LUSC cis rs868036 0.718 rs4776985 chr15:68123021 T/G cg08079166 chr15:68083412 MAP2K5 0.39 7.08 0.36 8.32e-12 Restless legs syndrome; LUSC cis rs7608623 0.773 rs7560892 chr2:23928637 A/G cg08917208 chr2:24149416 ATAD2B -0.42 -5.71 -0.3 2.48e-8 Obesity-related traits; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg11060661 chr22:24314208 DDT;DDTL 0.48 7.85 0.39 5.73e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg12311346 chr5:56204834 C5orf35 -0.88 -12.73 -0.57 1.55e-30 Initial pursuit acceleration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16860267 chr18:11908803 MPPE1 0.47 7.04 0.36 1.08e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7809950 0.953 rs3094383 chr7:107143164 G/A cg23024343 chr7:107201750 COG5 -0.55 -8.73 -0.43 1.27e-16 Coronary artery disease; LUSC cis rs3126085 0.935 rs4845426 chr1:152195359 A/G cg26876637 chr1:152193138 HRNR 0.44 6.29 0.33 1.01e-9 Atopic dermatitis; LUSC cis rs977987 0.843 rs12443904 chr16:75438770 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.04 -0.36 1.08e-11 Dupuytren's disease; LUSC cis rs3126085 0.935 rs10888467 chr1:152171707 C/T cg26876637 chr1:152193138 HRNR 0.46 6.45 0.33 3.84e-10 Atopic dermatitis; LUSC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg27535305 chr1:53392650 SCP2 -0.41 -7.61 -0.38 2.8e-13 Monocyte count; LUSC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg05368731 chr17:41323189 NBR1 0.92 15.94 0.66 5.93e-43 Menopause (age at onset); LUSC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.75 -0.35 6.42e-11 Total body bone mineral density; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg01802117 chr1:53393560 SCP2 -0.41 -6.89 -0.35 2.8e-11 Monocyte count; LUSC trans rs11039798 1.000 rs3902928 chr11:48581458 A/T cg15704280 chr7:45808275 SEPT13 0.69 6.51 0.34 2.81e-10 Axial length; LUSC cis rs11098499 0.754 rs17049949 chr4:120255290 A/G cg09307838 chr4:120376055 NA 0.69 10.49 0.5 1.94e-22 Corneal astigmatism; LUSC cis rs11190604 1.000 rs2003284 chr10:102202338 A/G cg07080220 chr10:102295463 HIF1AN 0.65 8.72 0.43 1.3e-16 Palmitoleic acid (16:1n-7) levels; LUSC trans rs7826238 0.539 rs2945891 chr8:8155475 C/T cg21775007 chr8:11205619 TDH 0.48 6.82 0.35 4.23e-11 Systolic blood pressure; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.73 0.75 5.96e-62 Homoarginine levels; LUSC cis rs4242434 0.927 rs720746 chr8:22471399 T/C cg03733263 chr8:22462867 KIAA1967 1.01 18.64 0.71 1.2e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg26677194 chr12:130822605 PIWIL1 0.6 8.97 0.44 2.13e-17 Menopause (age at onset); LUSC trans rs11098499 0.863 rs10013305 chr4:120450424 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs8141529 0.732 rs5762815 chr22:29205076 A/G cg15103426 chr22:29168792 CCDC117 0.6 8.34 0.42 1.91e-15 Lymphocyte counts; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04885475 chr3:157827967 RSRC1 -0.4 -6.04 -0.31 4.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg14829155 chr15:31115871 NA 0.55 7.8 0.39 8.02e-14 Huntington's disease progression; LUSC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg20503657 chr10:835505 NA 0.98 14.09 0.61 1.01e-35 Eosinophil percentage of granulocytes; LUSC cis rs4595586 0.545 rs2388175 chr12:39389217 A/G cg26384229 chr12:38710491 ALG10B 0.49 7.01 0.36 1.35e-11 Morning vs. evening chronotype; LUSC cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg16339924 chr4:17578868 LAP3 0.61 9.32 0.45 1.66e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6494488 0.500 rs72744738 chr15:65048334 C/G cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg03909902 chr12:108154529 PRDM4 -0.45 -6.59 -0.34 1.75e-10 Cognitive function;Information processing speed; LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.68 6.46 0.33 3.8e-10 Cerebrospinal P-tau181p levels; LUSC cis rs13256369 0.950 rs1522839 chr8:8580453 C/T cg00074818 chr8:8560427 CLDN23 0.53 8.51 0.42 5.86e-16 Obesity-related traits; LUSC cis rs62458065 0.568 rs62463963 chr7:32486691 C/T cg20159608 chr7:32802032 NA -0.74 -9.29 -0.45 1.96e-18 Metabolite levels (HVA/MHPG ratio); LUSC trans rs10805346 0.531 rs12498927 chr4:10115523 C/T cg26043149 chr18:55253948 FECH -0.42 -6.56 -0.34 2.09e-10 Urate levels in overweight individuals;Urate levels in obese individuals; LUSC trans rs9329221 0.576 rs1986972 chr8:10268805 C/T cg06636001 chr8:8085503 FLJ10661 0.48 6.34 0.33 7.59e-10 Neuroticism; LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg00814883 chr7:100076585 TSC22D4 -0.73 -9.76 -0.47 5.88e-20 Platelet count; LUSC cis rs7705502 0.962 rs72812847 chr5:173377817 G/A cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.33e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg00945038 chr17:61921165 SMARCD2 0.54 9.64 0.47 1.4e-19 Prudent dietary pattern; LUSC cis rs4776059 1.000 rs2288271 chr15:52886466 A/G cg22715398 chr15:52968154 KIAA1370 -0.72 -10.28 -0.49 1.01e-21 Schizophrenia; LUSC cis rs1728785 1.000 rs1364109 chr16:68595505 T/C cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.45e-10 Ulcerative colitis; LUSC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg05347473 chr6:146136440 FBXO30 0.54 9.12 0.45 7.02e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9818941 0.824 rs60410659 chr3:157811198 A/T cg08654915 chr3:157813417 NA 0.32 7.45 0.38 7.89e-13 Height; LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.7 -10.78 -0.51 1.87e-23 Platelet count; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg09033563 chr22:24373618 LOC391322 -0.59 -9.09 -0.45 8.91e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1062753 0.922 rs9611712 chr22:42410993 T/C cg22189786 chr22:42395067 WBP2NL 0.43 5.7 0.3 2.65e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs806215 1.000 rs327512 chr7:127257251 G/A cg25922125 chr7:127225783 GCC1 0.49 6.33 0.33 7.92e-10 Type 2 diabetes; LUSC cis rs11971779 0.680 rs28579232 chr7:139073116 C/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.81 0.65 2.04e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9326248 0.520 rs10892060 chr11:116881662 C/A cg20608306 chr11:116969690 SIK3 0.34 6.37 0.33 6.33e-10 Blood protein levels; LUSC cis rs4319547 0.656 rs10846664 chr12:122823777 C/T cg23029597 chr12:123009494 RSRC2 0.77 9.63 0.47 1.6e-19 Body mass index; LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.94 0.48 1.49e-20 Bipolar disorder; LUSC cis rs7909074 1.000 rs4481983 chr10:45400428 G/T cg04218760 chr10:45406644 TMEM72 -0.29 -6.96 -0.36 1.8e-11 Mean corpuscular volume; LUSC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg01181863 chr3:195395398 SDHAP2 -0.6 -8.11 -0.41 9.77e-15 Pancreatic cancer; LUSC cis rs2242194 0.816 rs6671688 chr1:154994265 T/C cg16680214 chr1:154839983 KCNN3 -0.35 -6.27 -0.32 1.14e-9 Schizophrenia; LUSC cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg22906224 chr7:99728672 NA 0.55 8.13 0.41 8.36e-15 Coronary artery disease; LUSC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg20476274 chr7:133979776 SLC35B4 0.85 16.36 0.67 1.29e-44 Mean platelet volume; LUSC cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg06618935 chr21:46677482 NA -0.36 -7.12 -0.36 6.71e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs208520 0.690 rs207094 chr6:66799009 G/A cg07460842 chr6:66804631 NA -1.14 -18.17 -0.71 8.4e-52 Exhaled nitric oxide output; LUSC cis rs447735 0.587 rs258336 chr16:89720831 A/C cg06640241 chr16:89574553 SPG7 0.4 5.85 0.3 1.17e-8 Hemoglobin concentration; LUSC cis rs59698941 0.943 rs10491277 chr5:132236361 G/C cg02081065 chr5:132209139 LEAP2 -0.65 -6.85 -0.35 3.55e-11 Apolipoprotein A-IV levels; LUSC cis rs7208859 0.623 rs11657990 chr17:29124200 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs4319547 0.586 rs7956480 chr12:122817507 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.28 -0.41 3.05e-15 Body mass index; LUSC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg01503450 chr10:980765 NA -0.4 -5.85 -0.3 1.15e-8 Eosinophil percentage of granulocytes; LUSC cis rs9398803 0.931 rs2045258 chr6:126674354 A/G cg19875578 chr6:126661172 C6orf173 0.41 6.1 0.32 2.95e-9 Male-pattern baldness; LUSC trans rs2204008 0.837 rs11168341 chr12:37961951 C/T cg06521331 chr12:34319734 NA -0.4 -6.02 -0.31 4.66e-9 Bladder cancer; LUSC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg06454157 chr6:167490870 NA -0.26 -6.02 -0.31 4.55e-9 Crohn's disease; LUSC cis rs4253772 0.591 rs9615938 chr22:46689468 G/A cg18190219 chr22:46762943 CELSR1 -0.55 -6.38 -0.33 5.88e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13819250 chr17:41560934 DHX8 0.44 6.24 0.32 1.35e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1153858 1.000 rs1719247 chr15:45620985 C/T cg14582100 chr15:45693742 SPATA5L1 0.57 10.11 0.48 3.77e-21 Homoarginine levels; LUSC cis rs13401104 0.796 rs11887905 chr2:237114756 C/T cg19324714 chr2:237145437 ASB18 0.43 5.88 0.31 9.94e-9 Educational attainment; LUSC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg18240062 chr17:79603768 NPLOC4 -0.79 -15.38 -0.64 9.93e-41 Eye color traits; LUSC cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg00277334 chr10:82204260 NA -0.93 -18.89 -0.72 1.19e-54 Post bronchodilator FEV1; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg16132339 chr22:24313637 DDTL;DDT 0.41 6.42 0.33 4.64e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg00701064 chr4:6280414 WFS1 0.59 14.24 0.61 2.82e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs2243480 0.901 rs12530490 chr7:65691647 G/A cg10756647 chr7:56101905 PSPH -0.87 -8.68 -0.43 1.81e-16 Diabetic kidney disease; LUSC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg11764359 chr7:65958608 NA 0.53 6.88 0.35 2.9e-11 Aortic root size; LUSC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg20476274 chr7:133979776 SLC35B4 0.83 15.21 0.64 4.51e-40 Mean platelet volume; LUSC cis rs7246967 0.673 rs3844578 chr19:22880610 G/C cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg08048268 chr3:133502702 NA -0.45 -8.75 -0.43 1.09e-16 Iron status biomarkers; LUSC cis rs6964587 0.869 rs11769294 chr7:91549937 C/T cg17063962 chr7:91808500 NA 0.53 8.2 0.41 5.16e-15 Breast cancer; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg19372772 chr2:264904 ACP1;SH3YL1 -0.55 -6.13 -0.32 2.41e-9 Height; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.47 0.46 5.12e-19 Bipolar disorder; LUSC cis rs7937682 0.632 rs4936800 chr11:111734097 T/A cg09085632 chr11:111637200 PPP2R1B 0.96 13.28 0.59 1.29e-32 Primary sclerosing cholangitis; LUSC trans rs459571 0.916 rs467303 chr9:136904835 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.76 -12.43 -0.56 2.09e-29 Platelet distribution width; LUSC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg21972741 chr5:435613 AHRR 0.34 6.37 0.33 6.38e-10 Cystic fibrosis severity; LUSC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg21880101 chr17:80066754 CCDC57 -0.31 -5.68 -0.3 3e-8 Life satisfaction; LUSC cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.58 -0.5 9.69e-23 Chronic sinus infection; LUSC cis rs2130392 0.886 rs2077205 chr4:185637418 C/T cg21366198 chr4:185655624 MLF1IP -0.42 -5.94 -0.31 7.05e-9 Kawasaki disease; LUSC trans rs656319 0.513 rs17746227 chr8:9981654 T/C cg15556689 chr8:8085844 FLJ10661 -0.48 -6.74 -0.35 7e-11 Myopia (pathological); LUSC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg12863693 chr15:85201151 NMB 0.34 6.79 0.35 5.23e-11 Schizophrenia; LUSC cis rs7129727 1 rs7129727 chr11:57484660 G/A cg02958346 chr11:57425731 CLP1 -0.41 -6.04 -0.31 4.19e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg11366901 chr6:160182831 ACAT2 -0.94 -13.39 -0.59 4.94e-33 Age-related macular degeneration (geographic atrophy); LUSC trans rs6030 0.869 rs9332599 chr1:169512980 G/A cg16792071 chr10:134842795 NA 0.3 6.16 0.32 2.05e-9 Uric acid levels; LUSC cis rs7267979 1.000 rs2258879 chr20:25279213 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4664308 0.618 rs3792192 chr2:160886875 G/A cg03641300 chr2:160917029 PLA2R1 -0.48 -7.96 -0.4 2.79e-14 Idiopathic membranous nephropathy; LUSC cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC trans rs877282 0.583 rs11253425 chr10:815173 G/A cg13042288 chr15:90349979 ANPEP -0.42 -6.26 -0.32 1.21e-9 Uric acid levels; LUSC trans rs12579753 0.789 rs35448307 chr12:82165817 A/G cg07923666 chr12:49932857 KCNH3 -0.48 -6.22 -0.32 1.51e-9 Resting heart rate; LUSC cis rs13064411 0.696 rs9836396 chr3:113184282 T/C cg18753928 chr3:113234510 CCDC52 -0.53 -8.27 -0.41 3.16e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs7106204 0.562 rs7109606 chr11:24251314 G/T ch.11.24196551F chr11:24239977 NA 0.91 10.09 0.48 4.56e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs8062405 0.789 rs240704 chr16:28529949 T/C cg16576597 chr16:28551801 NUPR1 0.28 5.71 0.3 2.54e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6733011 0.582 rs6757099 chr2:99415235 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.78 -0.3 1.73e-8 Bipolar disorder; LUSC cis rs2562456 0.876 rs11085465 chr19:21751790 A/G cg00806126 chr19:22604979 ZNF98 0.36 5.7 0.3 2.67e-8 Pain; LUSC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg00310523 chr12:86230176 RASSF9 -0.42 -8.0 -0.4 2e-14 Major depressive disorder; LUSC cis rs67696533 0.600 rs4911097 chr20:31121370 G/A cg13636640 chr20:31349939 DNMT3B 0.47 6.36 0.33 6.45e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs7712401 0.601 rs34233716 chr5:122316365 C/G cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg22907277 chr7:1156413 C7orf50 0.7 7.45 0.38 8.01e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg05340658 chr4:99064831 C4orf37 0.65 11.1 0.52 1.41e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs68170813 0.559 rs79705824 chr7:106848325 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.87e-20 Coronary artery disease; LUSC cis rs1044826 0.642 rs2071388 chr3:139236683 C/T cg00490450 chr3:139108681 COPB2 -0.47 -7.12 -0.36 6.7e-12 Obesity-related traits; LUSC cis rs1371867 0.846 rs1660330 chr8:101305015 T/A cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.54e-15 Atrioventricular conduction; LUSC cis rs11997175 0.583 rs7460295 chr8:33812288 C/T ch.8.33884649F chr8:33765107 NA 0.45 6.49 0.33 3.06e-10 Body mass index; LUSC cis rs9420 0.961 rs17455520 chr11:57540458 C/A cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.22e-10 Schizophrenia; LUSC cis rs9902453 0.817 rs59420007 chr17:28196114 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.79 0.47 4.72e-20 Coffee consumption (cups per day); LUSC cis rs672059 1.000 rs510642 chr1:183162776 A/C ch.1.3577855R chr1:183094577 LAMC1 0.55 8.1 0.41 1.02e-14 Hypertriglyceridemia; LUSC trans rs17169634 1.000 rs17169634 chr7:34093997 A/G cg18512313 chr14:70700886 NA 0.61 6.15 0.32 2.25e-9 Alzheimer's disease; LUSC trans rs2727020 0.658 rs10839269 chr11:49385596 A/G cg03929089 chr4:120376271 NA -0.98 -16.85 -0.68 1.54e-46 Coronary artery disease; LUSC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg22920501 chr2:26401640 FAM59B -0.73 -10.99 -0.52 3.54e-24 Gut microbiome composition (summer); LUSC cis rs637571 0.510 rs12575663 chr11:65574535 G/A cg10604040 chr11:65559109 OVOL1 0.31 5.78 0.3 1.72e-8 Eosinophil percentage of white cells; LUSC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg02807482 chr3:125708958 NA -0.52 -6.49 -0.33 3.08e-10 Blood pressure (smoking interaction); LUSC cis rs2439831 0.850 rs694985 chr15:43813387 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.86 9.63 0.47 1.62e-19 Lung cancer in ever smokers; LUSC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg23172400 chr8:95962367 TP53INP1 -0.43 -8.83 -0.43 6.16e-17 Type 2 diabetes; LUSC cis rs7189233 0.531 rs9921587 chr16:53475650 A/G cg09728985 chr16:53543985 NA -0.31 -5.81 -0.3 1.45e-8 Intelligence (multi-trait analysis); LUSC trans rs2018683 0.739 rs10233884 chr7:28972307 A/G cg19402173 chr7:128379420 CALU -0.46 -6.92 -0.35 2.31e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC trans rs12310956 0.532 rs2171534 chr12:33838998 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.59 0.34 1.74e-10 Morning vs. evening chronotype; LUSC cis rs231513 0.954 rs231516 chr17:41963205 G/A cg26893861 chr17:41843967 DUSP3 -0.52 -6.29 -0.33 1e-9 Cognitive function; LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg10360139 chr7:1886902 MAD1L1 -0.39 -5.96 -0.31 6.39e-9 Bipolar disorder and schizophrenia; LUSC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg12463550 chr7:65579703 CRCP 0.62 5.67 0.3 3.04e-8 Diabetic kidney disease; LUSC cis rs757110 0.834 rs1002226 chr11:17405617 C/T cg15432903 chr11:17409602 KCNJ11 0.62 11.29 0.53 2.95e-25 Type 2 diabetes; LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg16405210 chr4:1374714 KIAA1530 -0.81 -13.97 -0.61 2.91e-35 Longevity; LUSC cis rs1215050 0.740 rs2695464 chr4:98980929 T/C cg05340658 chr4:99064831 C4orf37 -0.47 -7.4 -0.38 1.14e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2692947 0.770 rs58730124 chr2:96413338 T/C cg22654517 chr2:96458247 NA 0.35 6.65 0.34 1.21e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg11366901 chr6:160182831 ACAT2 0.91 12.24 0.56 1.04e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.93e-12 Blood metabolite levels; LUSC cis rs7107174 1.000 rs10793311 chr11:78104399 G/C cg02023728 chr11:77925099 USP35 0.46 6.7 0.34 8.82e-11 Testicular germ cell tumor; LUSC cis rs12760731 0.546 rs6699087 chr1:178433200 G/T cg00404053 chr1:178313656 RASAL2 0.48 5.74 0.3 2.17e-8 Obesity-related traits; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.12 -0.48 3.44e-21 Obesity-related traits; LUSC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg25456477 chr12:86230367 RASSF9 0.42 7.54 0.38 4.42e-13 Major depressive disorder; LUSC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg03036452 chr22:46663545 TTC38 0.52 5.7 0.3 2.62e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs10779751 0.960 rs6661859 chr1:11301063 T/C cg08854313 chr1:11322531 MTOR 0.88 15.21 0.64 4.59e-40 Body mass index; LUSC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg06671706 chr8:8559999 CLDN23 0.48 6.48 0.33 3.29e-10 Obesity-related traits; LUSC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg24250549 chr1:154909240 PMVK 0.66 11.06 0.52 2.01e-24 Prostate cancer; LUSC trans rs911555 0.504 rs61995761 chr14:104075712 T/C cg03785828 chr5:81573306 RPS23 -0.37 -6.02 -0.31 4.56e-9 Intelligence (multi-trait analysis); LUSC cis rs4808199 0.894 rs9304960 chr19:19465529 G/A cg03709012 chr19:19516395 GATAD2A 0.99 12.05 0.55 5.02e-28 Nonalcoholic fatty liver disease; LUSC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg14558114 chr2:88469736 THNSL2 0.76 6.66 0.34 1.15e-10 Plasma clusterin levels; LUSC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg18876405 chr7:65276391 NA 0.6 9.57 0.46 2.42e-19 Aortic root size; LUSC cis rs8077577 0.895 rs11078412 chr17:18100618 C/T cg16794390 chr17:18148240 FLII -0.39 -5.69 -0.3 2.73e-8 Obesity-related traits; LUSC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.61 0.54 2.13e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg16434002 chr17:42200994 HDAC5 -0.46 -6.24 -0.32 1.31e-9 Total body bone mineral density; LUSC cis rs7959452 0.570 rs10878964 chr12:69720691 T/G cg11871910 chr12:69753446 YEATS4 0.67 10.32 0.49 7.44e-22 Blood protein levels; LUSC cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.55 0.57 7.07e-30 Motion sickness; LUSC cis rs7640424 0.750 rs13074183 chr3:107851467 G/A cg09227934 chr3:107805635 CD47 -0.41 -6.3 -0.33 9.21e-10 Body mass index; LUSC cis rs3857067 0.506 rs282450 chr4:95139598 G/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.46 -0.42 8.25e-16 QT interval; LUSC trans rs9329221 0.527 rs4841352 chr8:10327590 A/C cg15556689 chr8:8085844 FLJ10661 0.45 6.51 0.34 2.68e-10 Neuroticism; LUSC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 12.29 0.56 6.52e-29 Personality dimensions; LUSC cis rs7940866 0.803 rs10894307 chr11:130876350 G/A cg12179176 chr11:130786555 SNX19 0.64 9.79 0.47 4.58e-20 Schizophrenia; LUSC cis rs11051970 0.879 rs2651379 chr12:32581778 A/G cg02745156 chr12:32552066 NA 0.43 7.32 0.37 1.88e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.77 0.43 9.61e-17 Menopause (age at onset); LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg17279839 chr7:150038598 RARRES2 0.43 6.61 0.34 1.5e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs34779708 0.897 rs11010131 chr10:35513316 A/C cg03585969 chr10:35415529 CREM 0.64 9.52 0.46 3.56e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs911119 0.955 rs4815224 chr20:23594112 C/G cg16589663 chr20:23618590 CST3 0.64 7.68 0.39 1.82e-13 Chronic kidney disease; LUSC cis rs9595066 1.000 rs9595066 chr13:44706268 C/T cg04068111 chr13:44716778 NA -0.56 -7.95 -0.4 2.87e-14 Schizophrenia; LUSC cis rs6429082 0.818 rs291341 chr1:235663174 G/T cg26050004 chr1:235667680 B3GALNT2 0.61 8.23 0.41 4.14e-15 Adiposity; LUSC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg06001716 chr17:41278141 BRCA1;NBR2 -0.35 -5.75 -0.3 1.99e-8 Menopause (age at onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22307414 chr1:205601417 ELK4 -0.47 -6.22 -0.32 1.5e-9 Hepatitis; LUSC cis rs72829446 0.556 rs9907042 chr17:7402985 A/G cg02795151 chr17:7402630 POLR2A -0.59 -7.9 -0.4 4.19e-14 Androgen levels; LUSC cis rs7712401 0.601 rs30045 chr5:122271619 C/T cg19077854 chr5:122220652 SNX24 0.41 8.86 0.44 4.97e-17 Mean platelet volume; LUSC cis rs9300255 0.566 rs10744150 chr12:123721614 A/C cg05973401 chr12:123451056 ABCB9 0.51 7.06 0.36 9.93e-12 Neutrophil percentage of white cells; LUSC cis rs568617 1.000 rs693824 chr11:65654783 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.5 6.03 0.31 4.42e-9 Crohn's disease; LUSC cis rs548181 0.736 rs1941558 chr11:125425606 C/T cg03464685 chr11:125439445 EI24 1.24 14.17 0.61 5.13e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs3942852 0.759 rs905475 chr11:48149755 C/T cg03929089 chr4:120376271 NA -0.59 -7.11 -0.36 7.13e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs12474201 0.630 rs897529 chr2:46948175 T/C cg06386533 chr2:46925753 SOCS5 0.57 8.5 0.42 6.33e-16 Height; LUSC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 9.04 0.44 1.31e-17 Menopause (age at onset); LUSC cis rs8114671 0.935 rs6142313 chr20:33780427 A/G cg24642439 chr20:33292090 TP53INP2 -0.39 -5.72 -0.3 2.31e-8 Height; LUSC cis rs546131 0.928 rs483976 chr11:34840167 C/G cg06937548 chr11:34938143 PDHX;APIP 0.51 7.15 0.36 5.47e-12 Lung disease severity in cystic fibrosis; LUSC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg23719950 chr11:63933701 MACROD1 -0.6 -7.48 -0.38 6.57e-13 Mean platelet volume; LUSC cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg11266682 chr4:10021025 SLC2A9 0.56 9.99 0.48 9.83e-21 Bone mineral density; LUSC cis rs7223966 1.000 rs9895920 chr17:61852719 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.42 0.38 9.76e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4776059 0.798 rs58018557 chr15:52901284 T/C cg25063058 chr15:52860530 ARPP19 -0.48 -6.12 -0.32 2.64e-9 Schizophrenia; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg13397359 chr6:42928475 GNMT 0.58 9.83 0.47 3.48e-20 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs939658 0.776 rs35904425 chr15:79444567 G/A cg17916960 chr15:79447300 NA -0.54 -10.92 -0.51 6.05e-24 Refractive error; LUSC cis rs9486715 0.867 rs4839687 chr6:96951732 C/A cg06623918 chr6:96969491 KIAA0776 0.94 17.57 0.69 2.21e-49 Headache; LUSC cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.84 -0.51 1.15e-23 Alzheimer's disease (late onset); LUSC cis rs7712401 0.601 rs154506 chr5:122202781 A/G cg19077854 chr5:122220652 SNX24 0.41 9.11 0.45 7.65e-18 Mean platelet volume; LUSC cis rs9398803 0.865 rs1572569 chr6:126771687 G/A cg19875578 chr6:126661172 C6orf173 0.41 5.93 0.31 7.72e-9 Male-pattern baldness; LUSC cis rs4285028 0.948 rs35902163 chr3:121649526 G/A cg11130432 chr3:121712080 ILDR1 -0.65 -10.0 -0.48 9.21e-21 Multiple sclerosis; LUSC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg20476274 chr7:133979776 SLC35B4 0.87 17.01 0.68 3.4e-47 Mean platelet volume; LUSC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg11062466 chr8:58055876 NA 0.71 8.85 0.44 5.13e-17 Developmental language disorder (linguistic errors); LUSC cis rs921968 0.565 rs3770219 chr2:219619766 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg11861562 chr11:117069780 TAGLN -0.45 -8.14 -0.41 7.83e-15 Blood protein levels; LUSC trans rs7581030 0.958 rs6761251 chr2:71521191 T/G cg08113661 chr1:39457270 AKIRIN1 0.52 6.13 0.32 2.54e-9 Testicular germ cell tumor; LUSC cis rs3850699 0.666 rs7905481 chr10:104476292 T/C cg04362960 chr10:104952993 NT5C2 0.46 6.61 0.34 1.55e-10 Prostate cancer; LUSC trans rs12579753 1.000 rs34894912 chr12:82228721 A/G cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC trans rs1005277 0.540 rs11011351 chr10:38030525 A/G cg17830980 chr10:43048298 ZNF37B -0.4 -6.33 -0.33 7.81e-10 Extrinsic epigenetic age acceleration; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg07167872 chr1:205819463 PM20D1 0.88 16.98 0.68 4.65e-47 Menarche (age at onset); LUSC cis rs477692 0.563 rs7079165 chr10:131430240 G/A cg05714579 chr10:131428358 MGMT -0.71 -11.46 -0.53 7.06e-26 Response to temozolomide; LUSC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg23711669 chr6:146136114 FBXO30 0.91 17.06 0.68 2.16e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01498883 chr20:2451474 SNRPB 0.66 6.22 0.32 1.5e-9 Cognitive performance; LUSC cis rs2857891 0.773 rs2857897 chr11:6982082 A/C cg14883916 chr11:6947541 ZNF215 0.46 6.03 0.31 4.23e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs17604090 0.938 rs115369413 chr7:29685040 T/G cg19413766 chr7:29689036 LOC646762 -0.57 -6.65 -0.34 1.18e-10 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs6582630 0.599 rs7967598 chr12:38540760 C/T cg26384229 chr12:38710491 ALG10B -0.53 -8.03 -0.4 1.69e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg13560548 chr3:10150139 C3orf24 0.51 7.22 0.37 3.61e-12 Alzheimer's disease; LUSC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg13854012 chr2:162103682 NA -0.45 -8.11 -0.41 9.4e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg24692254 chr21:30365293 RNF160 -0.56 -8.16 -0.41 7.09e-15 Dental caries; LUSC cis rs7843479 0.544 rs11135735 chr8:21791557 C/T cg16476235 chr8:21771668 DOK2 0.24 5.68 0.3 2.92e-8 Mean corpuscular volume; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg24846343 chr22:24311635 DDTL -0.7 -14.49 -0.62 2.97e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg22676075 chr6:135203613 NA 0.59 9.48 0.46 5e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs1983891 1.000 rs1983891 chr6:41536427 A/G cg20194872 chr6:41519635 FOXP4 -0.36 -6.53 -0.34 2.5e-10 Prostate cancer; LUSC cis rs1322512 0.917 rs1744380 chr6:152942821 A/G cg27316956 chr6:152958899 SYNE1 0.36 5.99 0.31 5.4e-9 Tonometry; LUSC cis rs7572733 0.555 rs700671 chr2:198690001 T/C cg00792783 chr2:198669748 PLCL1 0.43 5.68 0.3 3.01e-8 Dermatomyositis; LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg15790184 chr11:494944 RNH1 0.42 6.42 0.33 4.69e-10 Systemic lupus erythematosus; LUSC cis rs6574644 0.959 rs12146981 chr14:81780858 C/T cg01989461 chr14:81687754 GTF2A1 0.49 6.0 0.31 5.11e-9 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03323092 chr20:42219682 IFT52 -0.43 -6.35 -0.33 7.23e-10 Electrocardiographic conduction measures; LUSC cis rs7772486 0.846 rs2492856 chr6:146323928 A/G cg23711669 chr6:146136114 FBXO30 0.84 14.93 0.63 5.97e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs7911264 0.739 rs10882094 chr10:94387676 T/A cg25093409 chr10:94429542 NA 0.36 6.21 0.32 1.59e-9 Inflammatory bowel disease; LUSC cis rs4466137 0.953 rs1585153 chr5:83000385 A/T cg15083037 chr5:83017644 HAPLN1 -0.61 -7.75 -0.39 1.13e-13 Prostate cancer; LUSC cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg16386425 chr10:429943 DIP2C -0.44 -7.06 -0.36 9.96e-12 Psychosis in Alzheimer's disease; LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg02951883 chr7:2050386 MAD1L1 -0.57 -10.53 -0.5 1.36e-22 Bipolar disorder and schizophrenia; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.45 -8.05 -0.4 1.44e-14 Electroencephalogram traits; LUSC cis rs9304742 0.611 rs10415443 chr19:53464864 C/G cg09503522 chr19:53445286 ZNF321 -0.36 -5.77 -0.3 1.79e-8 Psoriasis; LUSC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.71 -0.6 3.02e-34 Intelligence (multi-trait analysis); LUSC cis rs637571 0.522 rs606978 chr11:65711517 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.47 6.88 0.35 2.98e-11 Eosinophil percentage of white cells; LUSC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg03605463 chr16:89740564 NA 0.6 9.58 0.46 2.31e-19 Vitiligo; LUSC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg17971929 chr21:40555470 PSMG1 -0.48 -7.24 -0.37 3.08e-12 Menarche (age at onset); LUSC cis rs3808502 0.516 rs6983727 chr8:11415812 A/G cg27411982 chr8:10470053 RP1L1 0.47 7.28 0.37 2.44e-12 Neuroticism; LUSC cis rs3820928 0.904 rs2396431 chr2:227765488 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.8 -0.39 8.08e-14 Pulmonary function; LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs28830936 0.966 rs1531140 chr15:42125234 C/T cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.72 -0.3 2.37e-8 Diastolic blood pressure; LUSC cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.6 0.34 1.57e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11105298 0.891 rs1054807 chr12:89913419 C/T cg00757033 chr12:89920650 WDR51B 0.59 10.25 0.49 1.3e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg04166393 chr7:2884313 GNA12 0.42 5.66 0.3 3.24e-8 Height; LUSC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg15145296 chr3:125709740 NA -0.53 -6.06 -0.31 3.63e-9 Blood pressure (smoking interaction); LUSC cis rs12950390 0.853 rs55745341 chr17:45855778 G/C cg03474202 chr17:45855739 NA -0.29 -6.69 -0.34 9.62e-11 IgG glycosylation; LUSC cis rs983392 0.709 rs1349667 chr11:59993346 T/A cg20284999 chr11:59952153 MS4A6A -0.37 -6.03 -0.31 4.31e-9 Alzheimer's disease (late onset); LUSC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg05110241 chr16:68378359 PRMT7 -0.55 -6.32 -0.33 8.3e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6545883 0.894 rs7602859 chr2:61458206 A/T cg15711740 chr2:61764176 XPO1 0.43 6.5 0.33 2.96e-10 Tuberculosis; LUSC cis rs7666738 0.546 rs10026181 chr4:98814118 C/T cg17366294 chr4:99064904 C4orf37 -0.51 -8.05 -0.4 1.5e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs34734847 1.000 rs56179458 chr12:121157535 G/A cg21892295 chr12:121157589 UNC119B -0.52 -9.54 -0.46 3.07e-19 Mean corpuscular volume; LUSC cis rs17604090 0.878 rs4000284 chr7:29726917 G/A cg19413766 chr7:29689036 LOC646762 -0.68 -8.66 -0.43 2.05e-16 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7618501 1.000 rs7372730 chr3:49790682 C/G cg12257692 chr3:49977190 RBM6 -0.21 -5.7 -0.3 2.69e-8 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.742 rs7832968 chr8:8652889 G/A cg18904891 chr8:8559673 CLDN23 0.43 6.34 0.33 7.51e-10 Mood instability; LUSC trans rs7937682 0.632 rs11214028 chr11:111761149 T/C cg18187862 chr3:45730750 SACM1L -0.54 -6.5 -0.34 2.98e-10 Primary sclerosing cholangitis; LUSC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg06238570 chr21:40685208 BRWD1 -0.53 -8.21 -0.41 4.79e-15 Menarche (age at onset); LUSC cis rs6456156 0.528 rs6936261 chr6:167469676 A/C cg25258033 chr6:167368657 RNASET2 0.37 5.76 0.3 1.91e-8 Primary biliary cholangitis; LUSC cis rs10186029 0.676 rs10187830 chr2:213964796 C/G cg08319019 chr2:214017104 IKZF2 0.6 8.84 0.44 5.61e-17 Systemic sclerosis; LUSC cis rs6066835 1.000 rs6125448 chr20:47353178 G/A cg18078177 chr20:47281410 PREX1 0.75 6.33 0.33 7.83e-10 Multiple myeloma; LUSC cis rs559928 0.557 rs7122408 chr11:63898826 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 7.27 0.37 2.53e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4478858 0.684 rs4949369 chr1:31723845 T/A cg00250761 chr1:31883323 NA -0.33 -8.01 -0.4 1.93e-14 Alcohol dependence; LUSC cis rs1577917 0.771 rs12199873 chr6:86294947 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -8.57 -0.42 3.85e-16 Response to antipsychotic treatment; LUSC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg18190219 chr22:46762943 CELSR1 -0.48 -6.0 -0.31 5.01e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg23248424 chr5:179741104 GFPT2 -0.48 -7.3 -0.37 2.08e-12 Height; LUSC cis rs12101261 1.000 rs12101261 chr14:81451229 C/T cg06600135 chr14:81408086 NA 0.44 6.44 0.33 4.17e-10 Graves' disease; LUSC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg05084668 chr3:125655381 ALG1L -0.48 -6.79 -0.35 5.06e-11 Blood pressure (smoking interaction); LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg14004847 chr7:1930337 MAD1L1 -0.44 -6.41 -0.33 5.02e-10 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg11764359 chr7:65958608 NA 0.54 6.96 0.36 1.83e-11 Aortic root size; LUSC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg13395646 chr4:1353034 KIAA1530 -0.78 -13.06 -0.58 8.75e-32 Obesity-related traits; LUSC cis rs6754311 0.638 rs1011361 chr2:136553639 G/A cg07169764 chr2:136633963 MCM6 -0.6 -7.9 -0.4 4.09e-14 Mosquito bite size; LUSC cis rs9341835 0.709 rs4358600 chr6:64153219 G/A cg00787780 chr6:64151745 NA -0.33 -5.7 -0.3 2.57e-8 Schizophrenia; LUSC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg15557168 chr22:42548783 NA -0.33 -5.69 -0.3 2.81e-8 Cognitive function; LUSC trans rs11098499 0.644 rs10012252 chr4:120559139 T/C cg25214090 chr10:38739885 LOC399744 0.43 6.68 0.34 1e-10 Corneal astigmatism; LUSC cis rs965469 0.652 rs6051837 chr20:3388994 G/T cg25506879 chr20:3388711 C20orf194 -0.47 -6.16 -0.32 2.12e-9 IFN-related cytopenia; LUSC cis rs3931020 0.688 rs452242 chr1:75225625 G/T cg21535942 chr1:75199100 CRYZ;TYW3 -0.46 -5.73 -0.3 2.19e-8 Resistin levels; LUSC trans rs10758161 1.000 rs10758161 chr9:32755028 A/G cg10613332 chr19:13368845 CACNA1A 0.37 6.1 0.32 2.9e-9 Immune response to anthrax vaccine; LUSC cis rs17253792 0.822 rs10149408 chr14:56046075 G/A cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.76 0.39 1.01e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg07167872 chr1:205819463 PM20D1 0.88 17.27 0.69 3.45e-48 Menarche (age at onset); LUSC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 2.83e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9287719 0.639 rs2357649 chr2:10696788 C/T cg00105475 chr2:10696890 NA -0.45 -7.69 -0.39 1.67e-13 Prostate cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02513924 chr11:124823857 CCDC15 0.41 6.01 0.31 4.84e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg22638593 chr5:131593259 PDLIM4 0.41 6.54 0.34 2.35e-10 Blood metabolite levels; LUSC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11890956 chr21:40555474 PSMG1 -0.91 -16.4 -0.67 9.03e-45 Cognitive function; LUSC cis rs12367572 0.965 rs10880696 chr12:45234989 A/G cg04608330 chr12:45269318 NELL2 0.55 8.98 0.44 1.98e-17 Gut microbiome composition (summer); LUSC cis rs4319547 0.915 rs7316734 chr12:123117425 A/G cg23029597 chr12:123009494 RSRC2 -0.69 -9.39 -0.46 9.83e-19 Body mass index; LUSC cis rs981844 0.775 rs17299561 chr4:154765480 C/T cg14289246 chr4:154710475 SFRP2 0.51 6.89 0.35 2.87e-11 Response to statins (LDL cholesterol change); LUSC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg18404041 chr3:52824283 ITIH1 -0.58 -9.82 -0.47 3.69e-20 Schizophrenia; LUSC cis rs6121246 0.909 rs6060812 chr20:30292803 C/T cg18721089 chr20:30220636 NA -0.35 -6.01 -0.31 4.91e-9 Mean corpuscular hemoglobin; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09368129 chr5:140071347 HARS2;HARS 0.43 6.14 0.32 2.34e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg12311346 chr5:56204834 C5orf35 -0.93 -13.04 -0.58 1.08e-31 Initial pursuit acceleration; LUSC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.5 0.34 2.87e-10 Schizophrenia; LUSC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg04450456 chr4:17643702 FAM184B 0.41 7.0 0.36 1.43e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg08677398 chr8:58056175 NA 0.52 7.0 0.36 1.41e-11 Developmental language disorder (linguistic errors); LUSC cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg24692254 chr21:30365293 RNF160 0.8 13.03 0.58 1.16e-31 Selective IgA deficiency; LUSC cis rs7508 0.511 rs208056 chr8:17822884 C/T cg01800426 chr8:17659068 MTUS1 -0.49 -6.1 -0.32 2.98e-9 Atrial fibrillation; LUSC cis rs6938 0.534 rs59945415 chr15:75228427 C/A cg10253484 chr15:75165896 SCAMP2 -0.5 -7.34 -0.37 1.61e-12 Breast cancer; LUSC cis rs4654899 0.758 rs6693055 chr1:21421813 C/T cg01072550 chr1:21505969 NA -0.51 -7.78 -0.39 9.1e-14 Superior frontal gyrus grey matter volume; LUSC cis rs9467773 1.000 rs6925703 chr6:26521589 G/A cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.64e-42 Intelligence (multi-trait analysis); LUSC cis rs8048589 0.604 rs62038898 chr16:12223637 A/G cg02910054 chr16:12241554 SNX29 0.47 5.8 0.3 1.56e-8 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg09034736 chr1:150693464 HORMAD1 0.46 6.62 0.34 1.45e-10 Melanoma; LUSC trans rs7615952 0.611 rs35321002 chr3:125612065 G/C cg07211511 chr3:129823064 LOC729375 -0.98 -12.25 -0.56 9.56e-29 Blood pressure (smoking interaction); LUSC cis rs11955175 1.000 rs79575541 chr5:40672422 C/G cg04002187 chr5:40835754 RPL37 0.67 5.87 0.31 1.04e-8 Bipolar disorder and schizophrenia; LUSC cis rs17102884 0.506 rs4899540 chr14:75403408 G/A cg08847533 chr14:75593920 NEK9 -0.55 -8.18 -0.41 6.01e-15 Neuroticism; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07421368 chr2:67624930 ETAA1 0.38 6.14 0.32 2.32e-9 Triglycerides; LUSC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.86 -0.44 4.82e-17 Breast cancer; LUSC cis rs2073300 0.609 rs6137950 chr20:23418722 T/A cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12367572 0.965 rs10785539 chr12:45233023 G/C cg04608330 chr12:45269318 NELL2 -0.57 -9.26 -0.45 2.6e-18 Gut microbiome composition (summer); LUSC cis rs2635047 0.967 rs12960444 chr18:44607314 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 7.54 0.38 4.47e-13 Educational attainment; LUSC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg02038168 chr22:39784481 NA -0.47 -7.53 -0.38 4.64e-13 Intelligence (multi-trait analysis); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg00095276 chr5:1068111 SLC12A7 0.45 6.32 0.33 8.34e-10 Cognitive function;Information processing speed; LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg14092988 chr3:52407081 DNAH1 0.32 6.27 0.32 1.11e-9 Bipolar disorder; LUSC cis rs7575217 0.643 rs2309996 chr2:101735838 T/G cg23907051 chr2:101730305 TBC1D8 -0.28 -7.59 -0.38 3.24e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs11229555 0.645 rs12273638 chr11:58186335 T/C cg15696309 chr11:58395628 NA -0.64 -7.76 -0.39 1.05e-13 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2361710 0.611 rs3816257 chr17:78074446 G/T cg06718696 chr17:78121285 EIF4A3 -0.59 -8.82 -0.43 6.43e-17 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg08999081 chr20:33150536 PIGU 0.43 7.84 0.39 6.3e-14 Coronary artery disease; LUSC cis rs7804356 1.000 rs17315334 chr7:26852860 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg18904891 chr8:8559673 CLDN23 0.55 7.56 0.38 3.95e-13 Obesity-related traits; LUSC cis rs17270561 0.609 rs4711096 chr6:25727054 A/G cg17691542 chr6:26056736 HIST1H1C 0.58 7.99 0.4 2.26e-14 Iron status biomarkers; LUSC cis rs7568458 0.811 rs1446668 chr2:85764960 G/T cg23752985 chr2:85803571 VAMP8 0.29 6.08 0.32 3.25e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg26061582 chr7:22766209 IL6 0.46 6.47 0.33 3.41e-10 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg15212455 chr7:39170539 POU6F2 -0.64 -10.67 -0.5 4.67e-23 IgG glycosylation; LUSC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg23791538 chr6:167370224 RNASET2 0.41 6.6 0.34 1.64e-10 Crohn's disease; LUSC cis rs7953249 0.656 rs2251468 chr12:121405126 A/C cg25281562 chr12:121454272 C12orf43 0.43 5.71 0.3 2.5e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC trans rs7726839 0.540 rs56325086 chr5:640728 G/A cg11887960 chr12:57824829 NA 0.54 6.73 0.35 7.51e-11 Obesity-related traits; LUSC cis rs62064224 0.905 rs9891969 chr17:30627085 C/T cg18200150 chr17:30822561 MYO1D 0.36 6.85 0.35 3.56e-11 Schizophrenia; LUSC cis rs10905065 0.965 rs10795541 chr10:5811954 A/G cg11519256 chr10:5708881 ASB13 -0.44 -6.56 -0.34 2.05e-10 Menopause (age at onset); LUSC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg19539972 chr4:7069911 GRPEL1 0.71 8.92 0.44 3.19e-17 Monocyte percentage of white cells; LUSC cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.66 0.65 7.82e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3008870 0.755 rs1024229 chr1:67512903 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.65 9.71 0.47 8.24e-20 Lymphocyte percentage of white cells; LUSC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg16545954 chr1:2118288 C1orf86 -0.35 -6.73 -0.35 7.36e-11 Height; LUSC cis rs10845606 1.000 rs10845607 chr12:12835228 C/T cg04607235 chr12:12878440 APOLD1 -0.48 -5.79 -0.3 1.64e-8 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6138458 1.000 rs6707 chr20:24944166 C/T cg06937882 chr20:24974362 C20orf3 -0.42 -7.22 -0.37 3.45e-12 Blood protein levels; LUSC cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg21535247 chr6:8435926 SLC35B3 0.57 8.67 0.43 1.96e-16 Motion sickness; LUSC cis rs9303280 0.806 rs36095411 chr17:38031865 T/G cg10909506 chr17:38081995 ORMDL3 0.35 6.05 0.31 3.84e-9 Self-reported allergy; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26044038 chr1:113261488 NA -0.4 -6.05 -0.31 3.98e-9 Electrocardiographic conduction measures; LUSC trans rs3806843 1.000 rs1548700 chr5:140164889 A/T cg25815440 chr2:42134162 NA -0.25 -5.96 -0.31 6.49e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.38 -0.37 1.31e-12 Extrinsic epigenetic age acceleration; LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg19266014 chr7:2183958 MAD1L1 -0.35 -5.91 -0.31 8.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC trans rs17007017 1.000 rs11100712 chr4:142160229 C/T cg23562473 chr19:51334972 KLK15 0.3 6.16 0.32 2.09e-9 Conduct disorder; LUSC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.46 -6.07 -0.31 3.57e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.52 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg04414720 chr1:150670196 GOLPH3L 0.51 7.81 0.39 7.35e-14 Melanoma; LUSC cis rs6831352 0.879 rs1230154 chr4:99988659 C/T cg12011299 chr4:100065546 ADH4 0.73 11.12 0.52 1.21e-24 Alcohol dependence; LUSC cis rs7681440 0.583 rs2737034 chr4:90777464 C/G cg06632027 chr4:90757378 SNCA -0.37 -5.75 -0.3 1.99e-8 Dementia with Lewy bodies; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12698343 chr2:158485436 ACVR1C -0.38 -6.13 -0.32 2.48e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2970818 0.614 rs11063213 chr12:4632967 A/G cg11146114 chr12:4671731 NA -0.57 -6.06 -0.31 3.63e-9 Phosphorus levels; LUSC cis rs6701037 1.000 rs12747817 chr1:175118895 C/T cg00321850 chr1:175162397 KIAA0040 -0.43 -7.4 -0.38 1.14e-12 Alcohol dependence; LUSC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs208520 0.909 rs62414639 chr6:67023706 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 8.74 0.43 1.13e-16 Exhaled nitric oxide output; LUSC cis rs1858037 0.836 rs1396209 chr2:65601234 A/G cg08085232 chr2:65598271 SPRED2 -0.42 -6.27 -0.32 1.09e-9 Rheumatoid arthritis; LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg01503450 chr10:980765 NA -0.39 -5.72 -0.3 2.34e-8 Eosinophil percentage of granulocytes; LUSC cis rs4499344 0.881 rs6510263 chr19:33067367 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.61 -7.73 -0.39 1.29e-13 Mean platelet volume; LUSC cis rs739401 0.572 rs389285 chr11:3062673 G/A cg08508325 chr11:3079039 CARS -0.55 -13.66 -0.6 4.51e-34 Longevity; LUSC cis rs9311676 0.632 rs57700771 chr3:58360327 G/A cg13750441 chr3:58318267 PXK 0.34 6.66 0.34 1.1e-10 Systemic lupus erythematosus; LUSC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC trans rs3808502 0.503 rs2061830 chr8:11397457 C/G cg06636001 chr8:8085503 FLJ10661 0.62 9.55 0.46 2.94e-19 Neuroticism; LUSC cis rs10904908 0.763 rs10795469 chr10:17334935 A/G cg01003015 chr10:17271136 VIM 0.42 5.91 0.31 8.52e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs7264396 0.887 rs6060435 chr20:34069370 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.4 6.21 0.32 1.57e-9 Total cholesterol levels; LUSC trans rs62238980 0.614 rs116982428 chr22:32381272 G/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs12760731 0.565 rs78577576 chr1:178141982 A/G cg00404053 chr1:178313656 RASAL2 0.66 6.8 0.35 4.85e-11 Obesity-related traits; LUSC cis rs6840360 0.554 rs13108359 chr4:152727852 T/C cg22705602 chr4:152727874 NA 0.36 7.73 0.39 1.31e-13 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg02951883 chr7:2050386 MAD1L1 -0.35 -5.94 -0.31 7.07e-9 Bipolar disorder and schizophrenia; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg27487227 chr17:77813221 CBX4 0.38 6.05 0.31 3.85e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9359856 0.518 rs11962279 chr6:90233695 A/C cg13799429 chr6:90582589 CASP8AP2 -0.58 -6.04 -0.31 4.19e-9 Bipolar disorder; LUSC cis rs1728785 1.000 rs1728792 chr16:68596534 G/C cg02972257 chr16:68554789 NA -0.51 -6.57 -0.34 1.94e-10 Ulcerative colitis; LUSC cis rs11608355 0.618 rs11066368 chr12:109790342 C/T cg19025524 chr12:109796872 NA -0.47 -9.01 -0.44 1.67e-17 Neuroticism; LUSC trans rs2797160 1.000 rs9321050 chr6:126001568 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.74 -0.35 6.9e-11 Endometrial cancer; LUSC cis rs8077889 0.917 rs60335331 chr17:41907509 A/G cg26893861 chr17:41843967 DUSP3 0.87 13.46 0.59 2.75e-33 Triglycerides; LUSC cis rs877282 1.000 rs12779159 chr10:772143 T/C cg17470449 chr10:769945 NA 0.54 7.31 0.37 1.96e-12 Uric acid levels; LUSC cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.62e-8 Morning vs. evening chronotype; LUSC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg17971929 chr21:40555470 PSMG1 -0.48 -6.96 -0.36 1.83e-11 Menarche (age at onset); LUSC cis rs11098499 0.863 rs3822192 chr4:120445720 A/C cg24375607 chr4:120327624 NA 0.77 11.23 0.52 4.84e-25 Corneal astigmatism; LUSC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg15448220 chr1:150897856 SETDB1 0.41 5.88 0.31 9.89e-9 Melanoma; LUSC trans rs11098499 0.865 rs28634456 chr4:120375778 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.48 0.33 3.25e-10 Corneal astigmatism; LUSC cis rs892961 0.836 rs8071497 chr17:75414358 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.68e-19 Airflow obstruction; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.82 -0.39 6.83e-14 Lymphocyte counts; LUSC cis rs2898681 0.519 rs6554057 chr4:53730147 A/T cg21521518 chr4:53727714 RASL11B 0.44 5.78 0.3 1.73e-8 Optic nerve measurement (cup area); LUSC cis rs9811920 0.965 rs9837131 chr3:99854514 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.35 6.64 0.34 1.26e-10 Axial length; LUSC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg23583168 chr7:148888333 NA -0.82 -13.32 -0.59 9.32e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs4148689 0.904 rs10953847 chr7:117191819 T/C cg10450175 chr16:88689712 ZC3H18 0.47 6.09 0.32 3.08e-9 Gout; LUSC cis rs11971779 0.648 rs10230407 chr7:139103893 A/G cg23387468 chr7:139079360 LUC7L2 0.42 6.3 0.33 9.36e-10 Diisocyanate-induced asthma; LUSC cis rs7267979 0.966 rs2261720 chr20:25260641 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.74 0.75 5.32e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11992162 0.560 rs13256329 chr8:11782214 G/A cg21775007 chr8:11205619 TDH -0.41 -5.79 -0.3 1.62e-8 Monocyte count; LUSC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg17366294 chr4:99064904 C4orf37 0.61 10.91 0.51 6.72e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs1908814 0.516 rs10113145 chr8:11793295 A/G cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.77e-9 Neuroticism; LUSC cis rs7954584 0.635 rs7137218 chr12:122342877 G/T cg01765077 chr12:122356316 WDR66 0.5 7.28 0.37 2.47e-12 Mean corpuscular volume; LUSC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg22029157 chr1:209979665 IRF6 0.74 8.76 0.43 9.93e-17 Cleft lip with or without cleft palate; LUSC trans rs35110281 0.774 rs2838323 chr21:44999086 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.75 0.47 6.15e-20 Mean corpuscular volume; LUSC cis rs2835872 0.896 rs721014 chr21:39008109 A/G cg20424643 chr21:39039972 KCNJ6 -0.39 -6.03 -0.31 4.26e-9 Electroencephalographic traits in alcoholism; LUSC trans rs9929218 0.954 rs9923925 chr16:68819444 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -11.02 -0.52 2.75e-24 Colorectal cancer; LUSC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs12367572 0.965 rs7979717 chr12:45242272 A/T cg04608330 chr12:45269318 NELL2 -0.58 -9.3 -0.45 1.96e-18 Gut microbiome composition (summer); LUSC cis rs8060686 0.545 rs3826164 chr16:68280317 A/G cg09835421 chr16:68378352 PRMT7 0.68 7.2 0.37 3.97e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg08213375 chr14:104286397 PPP1R13B -0.45 -8.15 -0.41 7.36e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg01570182 chr17:44337453 NA 0.71 10.62 0.5 6.7e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg22903657 chr4:1355424 KIAA1530 -0.47 -7.88 -0.4 4.59e-14 Obesity-related traits; LUSC cis rs4343996 1.000 rs6959702 chr7:3356286 G/C cg21248987 chr7:3385318 SDK1 -0.38 -6.5 -0.34 2.9e-10 Motion sickness; LUSC cis rs4595586 0.545 rs6580894 chr12:39371951 A/G cg13010199 chr12:38710504 ALG10B 0.43 6.17 0.32 2e-9 Morning vs. evening chronotype; LUSC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg11764359 chr7:65958608 NA 0.79 13.07 0.58 8.12e-32 Aortic root size; LUSC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg22535103 chr8:58192502 C8orf71 -0.77 -9.95 -0.48 1.31e-20 Developmental language disorder (linguistic errors); LUSC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.27 -0.32 1.1e-9 Total body bone mineral density; LUSC trans rs561341 1.000 rs7210970 chr17:30262169 G/A cg20587970 chr11:113659929 NA -0.98 -12.25 -0.56 9.9e-29 Hip circumference adjusted for BMI; LUSC cis rs7267979 1.000 rs6083809 chr20:25329309 A/G cg03522245 chr20:25566470 NINL -0.35 -5.71 -0.3 2.45e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg18390621 chr1:3553628 WDR8 -0.39 -6.08 -0.32 3.23e-9 N-glycan levels; LUSC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg12463550 chr7:65579703 CRCP 0.42 6.04 0.31 4.09e-9 Calcium levels; LUSC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03517284 chr6:25882590 NA -0.5 -8.62 -0.43 2.77e-16 Intelligence (multi-trait analysis); LUSC cis rs2797160 1.000 rs1739363 chr6:126020980 G/A cg05901451 chr6:126070800 HEY2 0.57 8.76 0.43 1.03e-16 Endometrial cancer; LUSC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg09796270 chr17:17721594 SREBF1 -0.45 -7.9 -0.4 4.09e-14 Strep throat; LUSC cis rs17401966 0.540 rs1467653 chr1:10413123 A/G cg19773385 chr1:10388646 KIF1B 0.37 6.48 0.33 3.33e-10 Hepatocellular carcinoma; LUSC cis rs7568458 0.870 rs1972297 chr2:85808573 T/C cg23752985 chr2:85803571 VAMP8 0.36 7.77 0.39 9.6e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg16325326 chr1:53192061 ZYG11B -0.88 -16.23 -0.66 4.26e-44 Monocyte count; LUSC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg11812906 chr14:75593930 NEK9 -0.63 -10.39 -0.49 4.37e-22 Height; LUSC cis rs7267979 1.000 rs2500446 chr20:25339664 C/T cg03522245 chr20:25566470 NINL -0.35 -5.69 -0.3 2.85e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3768617 0.510 rs10797846 chr1:183087485 A/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg14456004 chr13:21872349 NA 0.43 6.01 0.31 4.74e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg23985595 chr17:80112537 CCDC57 0.33 6.29 0.33 1.01e-9 Life satisfaction; LUSC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.1 -0.32 2.98e-9 Total body bone mineral density; LUSC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg25072359 chr17:41440525 NA 0.56 8.35 0.42 1.79e-15 Menopause (age at onset); LUSC cis rs7809950 0.817 rs2807 chr7:107260778 G/A cg23024343 chr7:107201750 COG5 0.66 9.63 0.47 1.5700000000000001e-19 Coronary artery disease; LUSC trans rs4332037 0.539 rs55773130 chr7:2070554 T/C cg25206134 chr2:45395956 NA 0.59 6.91 0.35 2.4e-11 Bipolar disorder; LUSC cis rs4595586 0.505 rs76485055 chr12:39358294 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs78572108 0.858 rs13409978 chr2:42265702 A/C cg00607755 chr2:42274082 PKDCC 0.34 6.17 0.32 1.94e-9 Total body bone mineral density; LUSC cis rs55882075 0.537 rs62406698 chr5:179110429 C/T cg14593053 chr5:179126677 CANX 0.38 5.93 0.31 7.71e-9 Monocyte percentage of white cells; LUSC cis rs10751667 0.666 rs7395182 chr11:927553 A/C ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg04398451 chr17:18023971 MYO15A 0.67 12.07 0.55 4.42e-28 Total body bone mineral density; LUSC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.55 5.77 0.3 1.8e-8 Cerebrospinal P-tau181p levels; LUSC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg13390004 chr1:15929781 NA 0.41 6.87 0.35 3.15e-11 Systolic blood pressure; LUSC cis rs7267979 0.753 rs404148 chr20:25447931 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.77 15.22 0.64 4.14e-40 Liver enzyme levels (alkaline phosphatase); LUSC cis rs72781680 0.846 rs55770503 chr2:24030126 A/T cg08917208 chr2:24149416 ATAD2B 0.86 9.71 0.47 8.84e-20 Lymphocyte counts; LUSC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs950169 0.881 rs62029596 chr15:84955434 A/G cg17173187 chr15:85201210 NMB 0.37 6.4 0.33 5.31e-10 Schizophrenia; LUSC cis rs713587 0.525 rs11675457 chr2:25079770 C/T cg01884057 chr2:25150051 NA 0.43 10.03 0.48 7.09e-21 Body mass index in non-asthmatics; LUSC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.74 -0.35 6.77e-11 Alzheimer's disease (late onset); LUSC cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.79 0.57 9.23e-31 Hip circumference adjusted for BMI; LUSC cis rs9611565 0.546 rs5758426 chr22:42098763 T/G cg17376030 chr22:41985996 PMM1 -0.45 -5.97 -0.31 6.19e-9 Vitiligo; LUSC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg01448562 chr3:133502909 NA -0.52 -7.75 -0.39 1.12e-13 Iron status biomarkers; LUSC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.68 10.48 0.5 2.1e-22 Monocyte percentage of white cells; LUSC cis rs3733418 0.929 rs13120990 chr4:165905118 A/G cg08992305 chr4:165878219 TRIM61;C4orf39 -0.51 -5.93 -0.31 7.64e-9 Obesity-related traits; LUSC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg00033643 chr7:134001901 SLC35B4 0.46 7.28 0.37 2.47e-12 Mean platelet volume; LUSC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg20821713 chr7:1055600 C7orf50 -0.46 -6.91 -0.35 2.48e-11 Bronchopulmonary dysplasia; LUSC cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg16049864 chr8:95962084 TP53INP1 -0.65 -12.06 -0.55 4.59e-28 Type 2 diabetes; LUSC cis rs72781680 0.898 rs56303870 chr2:24086944 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.73 0.3 2.2e-8 Lymphocyte counts; LUSC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg24531977 chr5:56204891 C5orf35 -1.0 -14.65 -0.63 7.31e-38 Initial pursuit acceleration; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.3 0.41 2.67e-15 Prudent dietary pattern; LUSC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg06618935 chr21:46677482 NA 0.36 7.28 0.37 2.35e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3862030 0.720 rs7342070 chr10:104223628 T/C cg22532475 chr10:104410764 TRIM8 0.26 6.07 0.32 3.5e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg20703375 chr7:98957328 ARPC1A -0.4 -6.24 -0.32 1.31e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg27170947 chr2:26402098 FAM59B -0.67 -10.25 -0.49 1.29e-21 Gut microbiome composition (summer); LUSC cis rs11105298 0.891 rs11105314 chr12:89924559 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.5 -6.86 -0.35 3.31e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2267681 0.508 rs4726815 chr7:139514460 C/G cg14116596 chr7:139528673 TBXAS1 0.36 6.31 0.33 9.11e-10 Cervical cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07077507 chr14:89290791 TTC8 0.33 6.0 0.31 5.15e-9 Triglycerides; LUSC cis rs4474465 0.790 rs4945293 chr11:78254554 T/C cg27205649 chr11:78285834 NARS2 0.52 6.2 0.32 1.7e-9 Alzheimer's disease (survival time); LUSC trans rs4942242 0.663 rs9590779 chr13:44234886 A/G cg19169023 chr15:41853346 TYRO3 0.61 9.36 0.46 1.24e-18 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg24399712 chr22:39784796 NA -0.63 -11.38 -0.53 1.38e-25 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg21724239 chr8:58056113 NA 0.56 6.86 0.35 3.37e-11 Developmental language disorder (linguistic errors); LUSC cis rs6690583 0.943 rs1837329 chr1:85469614 G/A cg22153463 chr1:85462885 MCOLN2 -0.66 -8.14 -0.41 7.78e-15 Serum sulfate level; LUSC cis rs68170813 0.559 rs75007274 chr7:106814543 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.68 -0.47 1.04e-19 Coronary artery disease; LUSC cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg24692254 chr21:30365293 RNF160 0.66 10.22 0.49 1.68e-21 Selective IgA deficiency; LUSC cis rs12760731 0.720 rs35781686 chr1:178261262 G/A cg00404053 chr1:178313656 RASAL2 0.64 6.76 0.35 6.32e-11 Obesity-related traits; LUSC trans rs76248362 1.000 rs4770507 chr13:24434744 T/G cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs9303401 0.527 rs2116450 chr17:56745561 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.66 0.57 2.81e-30 Cognitive test performance; LUSC cis rs6693567 0.565 rs10157197 chr1:150250636 G/A cg09579323 chr1:150459698 TARS2 -0.43 -6.03 -0.31 4.43e-9 Migraine; LUSC cis rs6591182 0.935 rs11606601 chr11:65354439 C/G cg27068330 chr11:65405492 SIPA1 -0.47 -6.58 -0.34 1.79e-10 Non-alcoholic fatty liver disease histology (lobular); LUSC cis rs6598955 0.724 rs7547520 chr1:26592310 C/T cg00852783 chr1:26633632 UBXN11 0.49 8.71 0.43 1.45e-16 Obesity-related traits; LUSC cis rs62400317 0.762 rs62436374 chr6:44874785 C/G cg20913747 chr6:44695427 NA -0.48 -7.44 -0.38 8.79e-13 Total body bone mineral density; LUSC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg26850624 chr5:429559 AHRR -0.43 -8.43 -0.42 1.08e-15 Cystic fibrosis severity; LUSC cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC trans rs7829975 0.742 rs882462 chr8:8678530 G/A cg21775007 chr8:11205619 TDH 0.44 6.27 0.32 1.09e-9 Mood instability; LUSC cis rs13089785 1.000 rs13071800 chr3:123626813 C/A cg01860459 chr3:123419554 MYLK 0.35 5.95 0.31 6.6e-9 Intelligence (multi-trait analysis); LUSC trans rs11264799 0.765 rs12136747 chr1:157636930 C/G cg25498969 chr3:136062740 STAG1 0.23 5.99 0.31 5.46e-9 IgA nephropathy; LUSC cis rs6582630 0.638 rs10880620 chr12:38517467 A/G cg13010199 chr12:38710504 ALG10B -0.44 -6.7 -0.34 8.96e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg15147215 chr3:52552868 STAB1 -0.3 -6.08 -0.32 3.29e-9 Bipolar disorder; LUSC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.77 13.35 0.59 7.2e-33 Menarche (age at onset); LUSC cis rs7215564 0.730 rs2316066 chr17:78659785 A/G cg23238734 chr17:78661607 RPTOR 0.47 6.1 0.32 3e-9 Myopia (pathological); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg19603075 chr15:89010536 MRPS11;MRPL46 0.45 6.26 0.32 1.18e-9 Mosquito bite size; LUSC cis rs4718428 0.662 rs34577323 chr7:66310041 G/C cg12165864 chr7:66369176 NA -0.54 -7.26 -0.37 2.8e-12 Corneal structure; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14916315 chr19:4581550 NA 0.73 5.97 0.31 5.93e-9 Cognitive performance; LUSC trans rs4650994 0.525 rs2493860 chr1:178541492 A/G cg05059571 chr16:84539110 KIAA1609 -0.47 -8.95 -0.44 2.49e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.64 -8.27 -0.41 3.23e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC trans rs61931739 0.500 rs6488222 chr12:34526289 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs7267979 1.000 rs1888997 chr20:25298988 G/A cg08601574 chr20:25228251 PYGB -0.44 -6.79 -0.35 5.03e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7851660 0.874 rs10818175 chr9:100633386 T/C cg13688889 chr9:100608707 NA -0.56 -8.91 -0.44 3.48e-17 Strep throat; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs11971779 0.680 rs7805767 chr7:139111415 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7539409 0.651 rs970457 chr1:84296540 C/T cg10977910 chr1:84465055 TTLL7 0.65 6.8 0.35 4.97e-11 Alzheimer's disease; LUSC cis rs950169 0.960 rs12905475 chr15:84800495 G/A cg12863693 chr15:85201151 NMB 0.36 6.93 0.35 2.24e-11 Schizophrenia; LUSC trans rs10435719 0.780 rs9692662 chr8:11789863 C/T cg08975724 chr8:8085496 FLJ10661 0.48 7.02 0.36 1.24e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4604732 0.631 rs56704806 chr1:247626148 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs8114671 0.527 rs6060112 chr20:33489276 A/T cg07148914 chr20:33460835 GGT7 0.57 8.62 0.43 2.74e-16 Height; LUSC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg17219203 chr10:38645113 HSD17B7P2 0.4 5.81 0.3 1.48e-8 Extrinsic epigenetic age acceleration; LUSC cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg24642439 chr20:33292090 TP53INP2 0.47 7.17 0.37 4.84e-12 Glomerular filtration rate (creatinine); LUSC cis rs28655083 1.000 rs1875582 chr16:77063147 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.4 5.95 0.31 6.86e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2835872 1.000 rs2835872 chr21:39027272 G/A cg20424643 chr21:39039972 KCNJ6 0.48 7.13 0.36 6.13e-12 Electroencephalographic traits in alcoholism; LUSC cis rs2120019 0.938 rs8030089 chr15:75290377 C/T cg17294928 chr15:75287854 SCAMP5 -0.9 -12.79 -0.57 8.94e-31 Blood trace element (Zn levels); LUSC trans rs2587949 0.577 rs2166024 chr3:4211758 C/A cg15139668 chr4:4577005 NA 0.41 6.08 0.32 3.23e-9 Periodontitis (DPAL); LUSC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.76 0.68 3.58e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05181322 chr16:19078982 COQ7 -0.45 -6.13 -0.32 2.47e-9 Hepatitis; LUSC cis rs1322512 1.000 rs1282551 chr6:153009944 C/T cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs1322512 1.000 rs9371626 chr6:153008926 G/A cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs10979 0.679 rs9321918 chr6:143883460 T/C cg25407410 chr6:143891975 LOC285740 -0.64 -8.67 -0.43 1.86e-16 Hypospadias; LUSC cis rs3857536 0.706 rs7755994 chr6:66891747 T/C cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC trans rs9650657 0.537 rs7016385 chr8:10779472 A/G cg15556689 chr8:8085844 FLJ10661 0.47 6.52 0.34 2.57e-10 Neuroticism; LUSC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg21770322 chr7:97807741 LMTK2 0.4 7.01 0.36 1.31e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9747201 0.925 rs8072670 chr17:80159566 T/C cg17462356 chr17:80056334 FASN -0.44 -6.08 -0.32 3.25e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg07362569 chr17:61921086 SMARCD2 0.37 7.62 0.38 2.61e-13 Prudent dietary pattern; LUSC cis rs9788721 0.836 rs11858836 chr15:78783277 G/A cg18825076 chr15:78729989 IREB2 -0.63 -9.96 -0.48 1.23e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.59 -0.38 3.25e-13 Personality dimensions; LUSC cis rs9517320 1.000 rs7994160 chr13:99132749 C/A cg20487152 chr13:99095054 FARP1 0.34 6.27 0.32 1.09e-9 Longevity; LUSC cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg06028605 chr16:24865363 SLC5A11 0.68 10.63 0.5 6.19e-23 Intelligence (multi-trait analysis); LUSC cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg09184832 chr6:79620586 NA -0.44 -7.1 -0.36 7.73e-12 Intelligence (multi-trait analysis); LUSC cis rs950169 0.881 rs150965 chr15:85080527 T/G cg12863693 chr15:85201151 NMB 0.35 6.89 0.35 2.86e-11 Schizophrenia; LUSC cis rs7615952 0.673 rs35955861 chr3:125626201 T/C cg05084668 chr3:125655381 ALG1L -0.89 -12.9 -0.58 3.52e-31 Blood pressure (smoking interaction); LUSC cis rs3857536 0.813 rs7766786 chr6:66932889 C/A cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg06850241 chr22:41845214 NA 0.32 5.83 0.3 1.28e-8 Vitiligo; LUSC cis rs2204008 0.744 rs11168870 chr12:37973333 A/G cg26384229 chr12:38710491 ALG10B 0.93 15.94 0.66 5.93e-43 Bladder cancer; LUSC cis rs4917833 0.789 rs1060445 chr10:100218766 C/T cg19043522 chr10:100227446 HPSE2 0.41 5.87 0.31 1.06e-8 Pediatric bone mineral density (femoral neck); LUSC cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg01579765 chr21:45077557 HSF2BP -0.54 -11.2 -0.52 6.27e-25 Mean corpuscular volume; LUSC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg03609598 chr5:56110824 MAP3K1 -0.41 -5.87 -0.31 1.04e-8 Initial pursuit acceleration; LUSC trans rs2204008 0.744 rs11181337 chr12:38322083 C/A cg06521331 chr12:34319734 NA -0.4 -6.18 -0.32 1.88e-9 Bladder cancer; LUSC cis rs1023500 0.573 rs13057094 chr22:42470317 T/C cg04733989 chr22:42467013 NAGA 0.63 9.69 0.47 1.02e-19 Schizophrenia; LUSC cis rs926938 0.563 rs360630 chr1:115415132 C/T cg01522456 chr1:115632236 TSPAN2 -0.38 -5.77 -0.3 1.82e-8 Autism; LUSC cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs870825 0.655 rs28604350 chr4:185638723 G/A cg04058563 chr4:185651563 MLF1IP 0.88 13.12 0.58 5.36e-32 Blood protein levels; LUSC cis rs2346177 0.875 rs2346178 chr2:46647061 C/G cg02822958 chr2:46747628 ATP6V1E2 0.37 6.32 0.33 8.54e-10 HDL cholesterol; LUSC cis rs11971779 0.680 rs4077889 chr7:139033914 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.25 0.32 1.25e-9 Diisocyanate-induced asthma; LUSC cis rs7267979 1.000 rs2482943 chr20:25380593 G/A cg03522245 chr20:25566470 NINL -0.35 -5.72 -0.3 2.39e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9630089 0.622 rs7906782 chr10:98961596 C/T cg07221526 chr10:99185307 PGAM1 0.33 5.65 0.3 3.49e-8 Neutrophil percentage of white cells; LUSC cis rs9815354 0.812 rs73828505 chr3:42042714 C/T cg03022575 chr3:42003672 ULK4 0.6 6.33 0.33 7.76e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs9354308 0.933 rs2022856 chr6:66568235 G/T cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs1577917 0.727 rs2758840 chr6:86304625 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.67 -0.43 1.93e-16 Response to antipsychotic treatment; LUSC cis rs422249 0.634 rs174614 chr11:61628915 T/C cg06860612 chr11:61641270 FADS3 0.28 5.86 0.31 1.09e-8 Trans fatty acid levels; LUSC cis rs17270561 0.609 rs4711098 chr6:25734339 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg08859206 chr1:53392774 SCP2 0.49 8.26 0.41 3.56e-15 Monocyte count; LUSC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg22029157 chr1:209979665 IRF6 0.52 8.47 0.42 7.93e-16 Monobrow; LUSC cis rs10464366 0.746 rs11760807 chr7:39142377 G/A cg20302533 chr7:39170763 POU6F2 0.51 7.94 0.4 3.05e-14 IgG glycosylation; LUSC cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg00898013 chr13:113819073 PROZ -0.56 -8.08 -0.4 1.21e-14 Platelet distribution width; LUSC cis rs12971120 0.685 rs34780792 chr18:72173278 G/A cg26446133 chr18:72167187 CNDP2 -0.79 -9.76 -0.47 5.72e-20 Refractive error; LUSC cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.9 0.44 3.72e-17 Menopause (age at onset); LUSC cis rs4631830 0.863 rs10826125 chr10:51530505 G/A cg10326726 chr10:51549505 MSMB -0.37 -6.32 -0.33 8.4e-10 Prostate-specific antigen levels; LUSC cis rs9928842 1.000 rs7202566 chr16:75247644 C/A cg09066997 chr16:75300724 BCAR1 0.53 6.34 0.33 7.41e-10 Alcoholic chronic pancreatitis; LUSC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg08645402 chr16:4508243 NA 0.48 7.47 0.38 7.16e-13 Schizophrenia; LUSC cis rs3931020 0.657 rs10890142 chr1:75179129 G/A cg21535942 chr1:75199100 CRYZ;TYW3 0.46 5.75 0.3 2.06e-8 Resistin levels; LUSC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg00310523 chr12:86230176 RASSF9 0.42 7.87 0.4 5.05e-14 Major depressive disorder; LUSC cis rs2562456 0.917 rs10420016 chr19:21688602 C/G cg00806126 chr19:22604979 ZNF98 0.37 5.71 0.3 2.5e-8 Pain; LUSC trans rs60843830 1.000 rs60484953 chr2:221560 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 10.26 0.49 1.16e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg16850897 chr7:100343110 ZAN 0.37 5.89 0.31 9.47e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26317405 chr11:67188521 ATPGD1 0.44 5.96 0.31 6.36e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1163251 0.902 rs627707 chr1:120217133 C/G cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC cis rs9400467 0.528 rs10872067 chr6:111788391 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.32 -0.33 8.41e-10 Blood metabolite levels;Amino acid levels; LUSC trans rs61931739 0.500 rs11052966 chr12:34019826 C/T cg13010199 chr12:38710504 ALG10B 0.53 8.06 0.4 1.38e-14 Morning vs. evening chronotype; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.12e-18 Menopause (age at onset); LUSC cis rs911119 1.000 rs35488434 chr20:23620401 T/C cg16589663 chr20:23618590 CST3 0.59 6.95 0.36 1.9e-11 Chronic kidney disease; LUSC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg14703610 chr5:56206110 C5orf35 0.39 5.66 0.3 3.19e-8 Coronary artery disease; LUSC cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg27129171 chr3:47204927 SETD2 0.7 11.72 0.54 8.25e-27 Colorectal cancer; LUSC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg20891283 chr12:69753455 YEATS4 0.67 11.29 0.53 2.84e-25 Blood protein levels; LUSC cis rs3020736 0.500 rs6002618 chr22:42507859 G/C cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs10761482 0.813 rs2169081 chr10:62102389 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs9611565 0.570 rs12159188 chr22:42121125 A/T cg03806693 chr22:41940476 POLR3H 0.87 12.71 0.57 1.93e-30 Vitiligo; LUSC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.84e-11 Aortic root size; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg17502267 chr15:59981239 BNIP2 -0.45 -6.02 -0.31 4.48e-9 Cognitive function;Information processing speed; LUSC cis rs6967385 0.560 rs10248602 chr7:12347113 G/C cg20607287 chr7:12443886 VWDE 0.5 7.51 0.38 5.31e-13 Response to taxane treatment (placlitaxel); LUSC cis rs9818758 0.607 rs13087930 chr3:48961726 A/G cg00383909 chr3:49044727 WDR6 1.3 11.92 0.55 1.51e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs7223966 1.000 rs8069687 chr17:61883023 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.49 -6.89 -0.35 2.81e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs8072100 0.967 rs11871606 chr17:45732774 G/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.36 6.09 0.32 3.1e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6964587 0.934 rs73226382 chr7:91692760 T/C cg22709100 chr7:91322751 NA 0.39 5.7 0.3 2.58e-8 Breast cancer; LUSC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg18681998 chr4:17616180 MED28 0.85 15.67 0.65 6.85e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7539409 0.604 rs6689821 chr1:84316605 A/G cg10977910 chr1:84465055 TTLL7 0.75 7.9 0.4 4.07e-14 Alzheimer's disease; LUSC cis rs950027 0.620 rs1145076 chr15:45684508 G/T cg26924012 chr15:45694286 SPATA5L1 0.81 12.93 0.58 2.68e-31 Response to fenofibrate (adiponectin levels); LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC cis rs7094131 0.523 rs10764342 chr10:22882081 A/G cg19500236 chr10:22911537 PIP4K2A 0.36 6.31 0.33 8.99e-10 Obesity-related traits; LUSC cis rs12618769 0.625 rs113342082 chr2:99034198 G/A cg10123293 chr2:99228465 UNC50 0.47 7.9 0.4 3.99e-14 Bipolar disorder; LUSC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg01657329 chr11:68192670 LRP5 -0.45 -7.24 -0.37 3.17e-12 Total body bone mineral density; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.66 0.39 2.07e-13 Prudent dietary pattern; LUSC cis rs12891047 0.804 rs72725114 chr14:68317854 G/A cg20999565 chr14:68265668 ZFYVE26 0.39 5.86 0.31 1.11e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs983392 0.680 rs11230201 chr11:59996994 C/G cg02771260 chr11:59836817 MS4A3 -0.36 -5.93 -0.31 7.71e-9 Alzheimer's disease (late onset); LUSC cis rs4664304 0.772 rs12692572 chr2:160743793 G/A cg03641300 chr2:160917029 PLA2R1 0.35 5.68 0.3 2.91e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4332037 0.510 rs11764040 chr7:1884830 G/C cg12432903 chr7:1882776 MAD1L1 0.44 6.05 0.31 3.79e-9 Bipolar disorder; LUSC cis rs921968 0.541 rs485975 chr2:219374250 C/T cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg11062466 chr8:58055876 NA 0.51 7.05 0.36 1.06e-11 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg17279839 chr7:150038598 RARRES2 0.45 6.93 0.35 2.24e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs7264396 0.563 rs1970577 chr20:34336737 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.35 -0.42 1.87e-15 Total cholesterol levels; LUSC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg03929089 chr4:120376271 NA -1.01 -17.92 -0.7 8.54e-51 Coronary artery disease; LUSC cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.29 0.33 1.02e-9 Rheumatoid arthritis; LUSC cis rs806215 0.950 rs3757793 chr7:127225780 G/A cg25922125 chr7:127225783 GCC1 -0.61 -7.4 -0.38 1.11e-12 Type 2 diabetes; LUSC cis rs10876993 0.890 rs774887 chr12:58034835 A/G cg18357645 chr12:58087776 OS9 0.51 7.46 0.38 7.74e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg17366294 chr4:99064904 C4orf37 -0.56 -10.09 -0.48 4.4e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs546131 0.928 rs535719 chr11:34853382 A/G cg06937548 chr11:34938143 PDHX;APIP 0.5 7.05 0.36 1e-11 Lung disease severity in cystic fibrosis; LUSC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg22029157 chr1:209979665 IRF6 0.75 8.41 0.42 1.24e-15 Coronary artery disease; LUSC cis rs7605827 0.930 rs3805105 chr2:15535312 T/A cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg15147215 chr3:52552868 STAB1 -0.32 -6.33 -0.33 7.69e-10 Electroencephalogram traits; LUSC cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC trans rs7786808 0.536 rs4909210 chr7:158194376 T/C cg02030672 chr11:45687055 CHST1 0.5 8.09 0.4 1.12e-14 Obesity-related traits; LUSC cis rs7927771 0.524 rs6485786 chr11:47837408 G/C cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.94e-10 Subjective well-being; LUSC cis rs16854884 0.770 rs920158 chr3:143799289 A/T cg06585982 chr3:143692056 C3orf58 0.45 6.79 0.35 5.13e-11 Economic and political preferences (feminism/equality); LUSC cis rs7945705 0.869 rs4909952 chr11:8963946 A/G cg12365402 chr11:9010492 NRIP3 0.47 8.96 0.44 2.41e-17 Hemoglobin concentration; LUSC cis rs9300255 0.566 rs10744150 chr12:123721614 A/C cg00376283 chr12:123451042 ABCB9 0.69 9.81 0.47 3.98e-20 Neutrophil percentage of white cells; LUSC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.61 -8.14 -0.41 7.98e-15 Systemic lupus erythematosus; LUSC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg18225595 chr11:63971243 STIP1 0.65 11.24 0.52 4.33e-25 Platelet count; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg03354898 chr7:1950403 MAD1L1 -0.42 -8.36 -0.42 1.69e-15 Bipolar disorder and schizophrenia; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg03984733 chr9:116139085 HDHD3 0.5 6.38 0.33 5.81e-10 Cognitive function;Information processing speed; LUSC cis rs7851660 0.967 rs4743134 chr9:100598568 C/A cg13688889 chr9:100608707 NA -0.6 -10.34 -0.49 6.18e-22 Strep throat; LUSC cis rs7572644 0.766 rs11886375 chr2:28155748 A/C cg27432699 chr2:27873401 GPN1 0.53 6.54 0.34 2.37e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg17450446 chr1:160002111 PIGM 0.44 6.16 0.32 2.15e-9 Neuroticism; LUSC cis rs11098499 0.754 rs28643450 chr4:120245242 G/A cg09307838 chr4:120376055 NA 0.69 10.48 0.5 2.02e-22 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01067626 chr5:133512870 SKP1 -0.41 -6.08 -0.32 3.37e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9929218 0.954 rs4485355 chr16:68754730 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -12.02 -0.55 6.75e-28 Colorectal cancer; LUSC cis rs3858526 0.834 rs10838986 chr11:5977065 A/G cg02574844 chr11:5959923 NA -0.45 -6.26 -0.32 1.2e-9 DNA methylation (variation); LUSC cis rs2835872 0.965 rs857975 chr21:39001613 T/G cg20424643 chr21:39039972 KCNJ6 -0.4 -6.09 -0.32 3.09e-9 Electroencephalographic traits in alcoholism; LUSC trans rs12885221 0.542 rs7146994 chr14:33275517 A/T cg10551270 chr5:892523 TRIP13;BRD9 -0.39 -5.95 -0.31 6.94e-9 Intelligence (multi-trait analysis); LUSC cis rs6456156 0.846 rs7749827 chr6:167515624 C/T cg07741184 chr6:167504864 NA -0.33 -5.8 -0.3 1.57e-8 Primary biliary cholangitis; LUSC cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.28 0.41 3.07e-15 Axial length; LUSC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg12963246 chr6:28129442 ZNF389 0.52 7.12 0.36 6.72e-12 Depression; LUSC cis rs11864453 0.793 rs7197453 chr16:72079127 G/C cg01557791 chr16:72042693 DHODH -0.55 -7.91 -0.4 3.78e-14 Fibrinogen levels; LUSC cis rs6733011 0.628 rs6542838 chr2:99452458 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.68 -0.34 9.98e-11 Bipolar disorder; LUSC cis rs3126085 0.825 rs11204938 chr1:152193990 A/G cg26876637 chr1:152193138 HRNR 0.43 6.24 0.32 1.34e-9 Atopic dermatitis; LUSC cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg23158103 chr7:148848205 ZNF398 -0.5 -8.06 -0.4 1.38e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.52 5.95 0.31 6.75e-9 Schizophrenia; LUSC cis rs778371 0.748 rs1878287 chr2:233790649 G/T cg08000102 chr2:233561755 GIGYF2 -0.6 -8.0 -0.4 2.05e-14 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04987883 chr5:153826560 SAP30L 0.44 6.31 0.33 9.02e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7119038 0.818 rs57494551 chr11:118661398 C/T cg19308663 chr11:118741387 NA 0.4 6.8 0.35 4.79e-11 Sjögren's syndrome; LUSC cis rs8113142 0.614 rs4804847 chr19:29127396 C/T cg04546413 chr19:29218101 NA 0.43 5.94 0.31 7.07e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg24450063 chr1:156163899 SLC25A44 1.19 30.59 0.86 6.84e-99 Testicular germ cell tumor; LUSC trans rs2197308 0.765 rs68029712 chr12:37906585 T/G cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs12760731 0.565 rs12049568 chr1:178154345 A/G cg00404053 chr1:178313656 RASAL2 0.66 6.8 0.35 4.85e-11 Obesity-related traits; LUSC cis rs2439831 0.867 rs2251844 chr15:43836478 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.84 9.37 0.46 1.16e-18 Lung cancer in ever smokers; LUSC cis rs11148252 0.904 rs9568732 chr13:52993412 A/G cg00495681 chr13:53174319 NA -0.6 -10.99 -0.52 3.38e-24 Lewy body disease; LUSC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg03060546 chr3:49711283 APEH 0.7 11.78 0.54 5.06e-27 Resting heart rate; LUSC cis rs9300255 0.596 rs11057202 chr12:123720775 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.38 -0.33 5.87e-10 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.75 0.3 1.99e-8 Intelligence (multi-trait analysis); LUSC trans rs1994135 0.647 rs11052745 chr12:33695999 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.61 0.34 1.56e-10 Resting heart rate; LUSC trans rs2739330 0.828 rs4820572 chr22:24250355 T/C cg06437703 chr8:37914619 EIF4EBP1 -0.56 -8.71 -0.43 1.42e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11098499 0.908 rs9995234 chr4:120321827 A/G cg25214090 chr10:38739885 LOC399744 0.56 7.82 0.39 7.03e-14 Corneal astigmatism; LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.94 0.61 3.82e-35 Platelet count; LUSC cis rs2236918 0.932 rs1776131 chr1:242024245 T/A cg17736920 chr1:242011382 EXO1 0.46 7.22 0.37 3.6e-12 Menopause (age at onset); LUSC trans rs7824557 0.815 rs958648 chr8:11103895 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.82 -0.39 7.05e-14 Retinal vascular caliber; LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg18758796 chr5:131593413 PDLIM4 0.43 7.0 0.36 1.4e-11 Breast cancer; LUSC trans rs4332037 0.624 rs58169303 chr7:1883274 T/C cg10840412 chr1:235813424 GNG4 0.45 6.0 0.31 5.2e-9 Bipolar disorder; LUSC cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg13010199 chr12:38710504 ALG10B 0.48 7.49 0.38 6.31e-13 Morning vs. evening chronotype; LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.06 0.36 9.75e-12 Bipolar disorder; LUSC cis rs6539267 0.741 rs35816179 chr12:106693710 T/C cg00173435 chr12:106696525 TCP11L2 0.61 8.82 0.43 6.31e-17 Tourette syndrome; LUSC cis rs7119 0.651 rs8041398 chr15:77839173 A/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.44 -0.33 4.27e-10 Type 2 diabetes; LUSC cis rs11030122 0.632 rs10835556 chr11:4083013 A/G cg18678763 chr11:4115507 RRM1 -0.47 -6.29 -0.33 1e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs9815354 0.556 rs73073276 chr3:42025354 G/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs981844 0.775 rs921884 chr4:154753059 G/A cg14289246 chr4:154710475 SFRP2 -0.49 -6.73 -0.35 7.37e-11 Response to statins (LDL cholesterol change); LUSC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg01652190 chr22:50026171 C22orf34 -0.31 -6.35 -0.33 7.04e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg11764359 chr7:65958608 NA 0.68 11.03 0.52 2.49e-24 Aortic root size; LUSC cis rs868036 0.609 rs3784707 chr15:68043878 A/C cg24579218 chr15:68104479 NA -0.38 -6.24 -0.32 1.36e-9 Restless legs syndrome; LUSC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg23711669 chr6:146136114 FBXO30 0.9 17.22 0.69 5.31e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs6464929 0.956 rs4727006 chr7:148704935 A/G cg23583168 chr7:148888333 NA 0.46 5.83 0.3 1.31e-8 Pediatric bone mineral content (hip); LUSC cis rs7267979 0.833 rs6138556 chr20:25243310 C/T cg08601574 chr20:25228251 PYGB 0.46 7.18 0.37 4.43e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.75 0.77 5.98e-66 Prudent dietary pattern; LUSC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 8.46 0.42 8.64e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs7824557 0.544 rs1865521 chr8:11231249 T/C cg27411982 chr8:10470053 RP1L1 0.37 5.71 0.3 2.55e-8 Retinal vascular caliber; LUSC cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.52 0.34 2.52e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4319547 0.695 rs4758643 chr12:122924819 A/T cg23029597 chr12:123009494 RSRC2 -0.74 -9.23 -0.45 3.1e-18 Body mass index; LUSC cis rs34779708 0.931 rs7923172 chr10:35309367 G/A cg03585969 chr10:35415529 CREM 0.61 8.82 0.43 6.24e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2404618 0.506 rs12156177 chr8:1493684 C/T cg13402656 chr8:1511478 DLGAP2 -0.57 -9.51 -0.46 3.77e-19 Lung cancer; LUSC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg18357526 chr6:26021779 HIST1H4A 0.42 6.8 0.35 4.97e-11 Intelligence (multi-trait analysis); LUSC cis rs2354432 0.556 rs4424557 chr1:146871119 A/G cg25205988 chr1:146714368 CHD1L 0.88 7.86 0.39 5.45e-14 Mitochondrial DNA levels; LUSC cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.98e-12 Motion sickness; LUSC cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg05347473 chr6:146136440 FBXO30 0.41 6.91 0.35 2.54e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 0.839 rs9656002 chr7:91475007 A/G cg17063962 chr7:91808500 NA -0.56 -8.6 -0.43 3.19e-16 Breast cancer; LUSC cis rs600231 0.665 rs1626021 chr11:65226187 A/G cg21890820 chr11:65308645 LTBP3 0.51 7.55 0.38 4.3e-13 Bone mineral density; LUSC cis rs11792861 0.566 rs11792635 chr9:111848819 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.09 0.36 7.8e-12 Menarche (age at onset); LUSC cis rs1832871 0.683 rs11756200 chr6:158657736 A/G cg07165851 chr6:158734300 TULP4 0.51 7.63 0.39 2.43e-13 Height; LUSC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg21856205 chr7:94953877 PON1 -0.36 -5.8 -0.3 1.56e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9393777 0.588 rs6456727 chr6:26471155 T/C cg12826209 chr6:26865740 GUSBL1 0.66 7.76 0.39 1.04e-13 Intelligence (multi-trait analysis); LUSC cis rs10876993 0.928 rs2928053 chr12:58063475 T/C cg15848620 chr12:58087721 OS9 -0.55 -7.83 -0.39 6.43e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs6700896 0.931 rs11208716 chr1:66158825 C/T cg04111102 chr1:66153794 NA 0.33 7.34 0.37 1.61e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg11766577 chr21:47581405 C21orf56 0.47 7.09 0.36 8.02e-12 Testicular germ cell tumor; LUSC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg18350739 chr11:68623251 NA 0.38 6.9 0.35 2.55e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg00074818 chr8:8560427 CLDN23 0.55 9.39 0.46 9.44e-19 Obesity-related traits; LUSC cis rs8058578 0.943 rs35629860 chr16:30671532 G/A cg05768032 chr16:30646687 NA 0.4 5.81 0.3 1.47e-8 Multiple myeloma; LUSC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg24549020 chr5:56110836 MAP3K1 0.51 5.82 0.3 1.39e-8 Type 2 diabetes; LUSC cis rs4629180 0.586 rs1509495 chr2:102134834 C/T cg01388757 chr2:102091195 RFX8 -0.37 -6.43 -0.33 4.49e-10 Chronic rhinosinusitis with nasal polyps; LUSC cis rs9309473 0.607 rs10196402 chr2:73572081 A/C cg20560298 chr2:73613845 ALMS1 -0.49 -7.18 -0.37 4.69e-12 Metabolite levels; LUSC cis rs2835872 0.759 rs2835900 chr21:39075749 G/T cg20424643 chr21:39039972 KCNJ6 0.42 6.39 0.33 5.53e-10 Electroencephalographic traits in alcoholism; LUSC cis rs77741769 0.571 rs989986 chr12:121274178 A/C cg02419362 chr12:121203948 SPPL3 0.46 8.57 0.42 3.78e-16 Mean corpuscular volume; LUSC cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg26384229 chr12:38710491 ALG10B 0.89 14.84 0.63 1.26e-38 Bladder cancer; LUSC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg06850241 chr22:41845214 NA -0.3 -5.73 -0.3 2.26e-8 Vitiligo; LUSC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg25036284 chr2:26402008 FAM59B -0.68 -9.42 -0.46 7.91e-19 Gut microbiome composition (summer); LUSC cis rs12286929 0.644 rs3793957 chr11:115095654 C/T cg04055981 chr11:115044050 NA 0.37 6.63 0.34 1.39e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17621444 0.522 rs10788023 chr10:121812114 C/T cg02041677 chr10:121771263 NA -0.32 -6.09 -0.32 3.11e-9 IgG glycosylation; LUSC cis rs4919694 0.901 rs10509763 chr10:104776391 G/A cg23093090 chr10:104574429 C10orf26 -0.48 -5.8 -0.3 1.53e-8 Arsenic metabolism; LUSC trans rs6952808 0.823 rs58222895 chr7:1885064 G/A cg11244813 chr1:145039882 PDE4DIP 0.38 6.04 0.31 4.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs12579753 0.789 rs1343933 chr12:82123301 A/C cg07988820 chr12:82153109 PPFIA2 -0.45 -6.37 -0.33 6.27e-10 Resting heart rate; LUSC cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg22906224 chr7:99728672 NA 0.47 6.52 0.34 2.67e-10 Coronary artery disease; LUSC cis rs8017423 0.647 rs4900037 chr14:90821478 A/G cg04374321 chr14:90722782 PSMC1 0.41 6.2 0.32 1.68e-9 Mortality in heart failure; LUSC cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.48 -6.54 -0.34 2.3e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4654899 0.680 rs10799670 chr1:21179445 T/C cg01072550 chr1:21505969 NA 0.48 7.2 0.37 3.92e-12 Superior frontal gyrus grey matter volume; LUSC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg18827107 chr12:86230957 RASSF9 0.49 7.34 0.37 1.6e-12 Major depressive disorder; LUSC cis rs6495122 0.630 rs12912343 chr15:75251041 C/G cg09165964 chr15:75287851 SCAMP5 0.52 7.51 0.38 5.61e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs67460515 0.892 rs7647374 chr3:160975576 T/A cg03342759 chr3:160939853 NMD3 -0.55 -8.04 -0.4 1.62e-14 Parkinson's disease; LUSC cis rs6960043 0.818 rs10238625 chr7:15054232 A/G cg19272540 chr7:15055459 NA 0.36 8.95 0.44 2.48e-17 Type 2 diabetes; LUSC cis rs2072499 0.865 rs2758608 chr1:156202860 A/T cg24450063 chr1:156163899 SLC25A44 1.06 20.26 0.74 4.47e-60 Testicular germ cell tumor; LUSC cis rs4680 0.737 rs3810595 chr22:19949644 G/C cg23601416 chr22:19950040 COMT -0.45 -9.27 -0.45 2.39e-18 Blood metabolite levels; LUSC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.38 7.15 0.36 5.66e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs17818399 0.547 rs62134736 chr2:46766446 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.54 -6.9 -0.35 2.67e-11 Height; LUSC cis rs244731 0.959 rs918459 chr5:176669030 C/T cg16006841 chr5:176797999 RGS14 -0.65 -9.36 -0.46 1.19e-18 Urate levels in lean individuals; LUSC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg19346786 chr7:2764209 NA -0.42 -7.01 -0.36 1.32e-11 Height; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.16 0.52 8.78e-25 Prudent dietary pattern; LUSC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg06287003 chr12:125626642 AACS -0.41 -7.38 -0.37 1.25e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg04586622 chr2:25135609 ADCY3 0.41 8.88 0.44 4.05e-17 Body mass index; LUSC trans rs1493916 0.748 rs34501189 chr18:31314196 A/G cg27147174 chr7:100797783 AP1S1 -0.56 -8.85 -0.44 5.33e-17 Life satisfaction; LUSC cis rs4423214 1.000 rs12278461 chr11:71182185 C/T cg05163923 chr11:71159392 DHCR7 0.78 11.49 0.53 5.51e-26 Vitamin D levels; LUSC trans rs2797160 0.967 rs2797162 chr6:126011381 G/T cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg02772935 chr3:125709198 NA -0.5 -6.03 -0.31 4.34e-9 Blood pressure (smoking interaction); LUSC cis rs9902453 0.845 rs12452201 chr17:28214173 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 10.04 0.48 6.44e-21 Coffee consumption (cups per day); LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg01802117 chr1:53393560 SCP2 0.38 6.17 0.32 1.97e-9 Monocyte count; LUSC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg13939156 chr17:80058883 NA 0.34 6.78 0.35 5.54e-11 Life satisfaction; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg22963979 chr7:1858916 MAD1L1 -0.6 -9.44 -0.46 6.45e-19 Bipolar disorder and schizophrenia; LUSC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.74 0.6 2.26e-34 Platelet count; LUSC cis rs6060960 0.537 rs6087787 chr20:30452089 G/A cg13852791 chr20:30311386 BCL2L1 0.67 6.66 0.34 1.11e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg06028605 chr16:24865363 SLC5A11 0.67 10.26 0.49 1.2e-21 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9902453 0.709 rs6505162 chr17:28444183 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.52 7.48 0.38 6.79e-13 Coffee consumption (cups per day); LUSC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg09021430 chr5:549028 NA -0.53 -7.49 -0.38 6.08e-13 Lung disease severity in cystic fibrosis; LUSC cis rs66887589 0.807 rs9799664 chr4:120326678 C/T cg09307838 chr4:120376055 NA 0.46 6.81 0.35 4.45e-11 Diastolic blood pressure; LUSC cis rs11955175 0.850 rs111959286 chr5:40704141 A/T cg17351974 chr5:40835760 RPL37 0.67 5.8 0.3 1.54e-8 Bipolar disorder and schizophrenia; LUSC cis rs7903847 0.602 rs7916665 chr10:99157573 T/G cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs2832077 0.883 rs35672956 chr21:30189042 T/C cg24692254 chr21:30365293 RNF160 -0.58 -7.22 -0.37 3.57e-12 Cognitive test performance; LUSC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg08677398 chr8:58056175 NA 0.54 7.01 0.36 1.34e-11 Developmental language disorder (linguistic errors); LUSC cis rs7072216 0.763 rs6584200 chr10:100170037 A/G cg26618903 chr10:100175079 PYROXD2 -0.47 -8.81 -0.43 6.73e-17 Metabolite levels; LUSC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg11062466 chr8:58055876 NA 0.5 6.42 0.33 4.75e-10 Developmental language disorder (linguistic errors); LUSC trans rs6030 1.000 rs6701330 chr1:169501056 T/C cg16792071 chr10:134842795 NA 0.29 6.0 0.31 5.07e-9 Uric acid levels; LUSC cis rs1878931 0.559 rs2106863 chr16:3391330 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.63 10.03 0.48 7.36e-21 Body mass index (adult); LUSC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.16 0.32 2.11e-9 Mean platelet volume; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg16527491 chr14:38065127 FOXA1 -0.39 -5.99 -0.31 5.5e-9 Hepatitis; LUSC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg13939156 chr17:80058883 NA -0.33 -6.46 -0.33 3.62e-10 Life satisfaction; LUSC cis rs1372520 0.684 rs2572318 chr4:90718719 C/T cg01966878 chr4:90757139 SNCA -0.4 -5.89 -0.31 9.59e-9 Neuroticism; LUSC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs7223966 0.961 rs112709843 chr17:61836936 T/A cg05941027 chr17:61774174 LIMD2 0.22 5.95 0.31 6.89e-9 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg10994292 chr5:110074295 SLC25A46 0.41 6.34 0.33 7.46e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10170846 0.924 rs3768973 chr2:223436402 C/T cg25565276 chr2:223520875 FARSB 0.68 10.03 0.48 6.98e-21 Schizophrenia (inflammation and infection response interaction); LUSC cis rs1728785 1.000 rs7202306 chr16:68587684 G/A cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.4e-10 Ulcerative colitis; LUSC cis rs666930 1.000 rs666930 chr1:120258970 A/G cg19096424 chr1:120255104 PHGDH 0.41 6.32 0.33 8.19e-10 Breast cancer; LUSC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.07 -0.32 3.41e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -11.68 -0.54 1.17e-26 Chronic sinus infection; LUSC cis rs253664 0.948 rs1308362 chr3:138103927 A/T cg25188949 chr3:137893707 DBR1 -0.48 -5.75 -0.3 2.01e-8 Body mass index; LUSC trans rs3857536 0.813 rs9360189 chr6:66933424 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs12421382 0.659 rs11600110 chr11:109392438 A/G cg27471124 chr11:109292789 C11orf87 0.43 7.46 0.38 7.48e-13 Schizophrenia; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg17524151 chr16:475494 RAB11FIP3 0.41 6.36 0.33 6.5e-10 Calcium levels; LUSC cis rs10203711 0.966 rs10929288 chr2:239583146 A/G cg14580085 chr2:239553406 NA 0.42 7.1 0.36 7.48e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs1997103 1.000 rs6973337 chr7:55411534 T/C cg20935933 chr6:143382018 AIG1 0.51 7.43 0.38 8.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs868036 0.718 rs4776985 chr15:68123021 T/G cg05925327 chr15:68127851 NA -0.38 -6.02 -0.31 4.7e-9 Restless legs syndrome; LUSC trans rs67340775 0.541 rs200966 chr6:27862152 T/C cg06606381 chr12:133084897 FBRSL1 -0.51 -6.05 -0.31 3.8e-9 Lung cancer in ever smokers; LUSC trans rs7939886 0.920 rs7113835 chr11:55947007 C/T cg03929089 chr4:120376271 NA 0.82 6.22 0.32 1.53e-9 Myopia (pathological); LUSC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC cis rs4555082 0.874 rs11622166 chr14:105759763 C/A cg10792982 chr14:105748885 BRF1 0.51 8.74 0.43 1.12e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg23788917 chr6:8435910 SLC35B3 0.51 7.48 0.38 6.55e-13 Motion sickness; LUSC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.4 0.49 3.98e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg08999081 chr20:33150536 PIGU 0.52 10.19 0.49 2e-21 Glomerular filtration rate (creatinine); LUSC cis rs2348418 0.966 rs7316351 chr12:28698528 G/A cg13890972 chr12:28721907 NA -0.34 -5.75 -0.3 2.06e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs10992471 0.603 rs11792019 chr9:95195229 C/T cg14631576 chr9:95140430 CENPP -0.35 -6.48 -0.33 3.26e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs3087591 0.597 rs731759 chr17:29722809 A/T cg24425628 chr17:29625626 OMG;NF1 -0.4 -5.92 -0.31 8.1e-9 Hip circumference; LUSC cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 7.16 0.36 5.32e-12 Platelet count; LUSC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.75 0.6 2.12e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg10792982 chr14:105748885 BRF1 0.51 9.08 0.44 9.87e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs459482 1.000 rs464783 chr21:42796480 A/G cg14166395 chr21:42792516 MX1 -0.57 -8.4 -0.42 1.33e-15 IgG glycosylation; LUSC trans rs8072100 0.701 rs4794053 chr17:45769551 G/A cg03886242 chr7:26192032 NFE2L3 -0.41 -6.26 -0.32 1.22e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.28 0.32 1.07e-9 Alzheimer's disease; LUSC cis rs72781680 0.898 rs56303870 chr2:24086944 G/A cg08917208 chr2:24149416 ATAD2B 0.87 9.86 0.47 2.6e-20 Lymphocyte counts; LUSC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg04865166 chr7:105162814 PUS7 0.53 5.65 0.3 3.42e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg22875332 chr1:76189707 ACADM 0.83 14.09 0.61 1.05e-35 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs4295623 0.585 rs13259242 chr8:11593033 T/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.04 -0.31 4.05e-9 Morning vs. evening chronotype; LUSC cis rs12928939 0.859 rs11670 chr16:71679027 G/T cg08717414 chr16:71523259 ZNF19 -0.41 -5.65 -0.3 3.39e-8 Post bronchodilator FEV1; LUSC cis rs7173743 0.518 rs12899452 chr15:79112550 T/A cg00540400 chr15:79124168 NA 0.45 8.02 0.4 1.76e-14 Coronary artery disease; LUSC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg00815214 chr21:47717953 NA -0.43 -6.66 -0.34 1.14e-10 Testicular germ cell tumor; LUSC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg20203395 chr5:56204925 C5orf35 -0.4 -5.83 -0.3 1.3e-8 Coronary artery disease; LUSC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg05623727 chr3:50126028 RBM5 -0.35 -6.5 -0.34 2.92e-10 Body mass index; LUSC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 10.22 0.49 1.57e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4604732 0.578 rs12036417 chr1:247624805 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg27446573 chr6:127587934 RNF146 0.84 13.58 0.6 9.16e-34 Breast cancer; LUSC cis rs394563 0.967 rs438852 chr6:149794533 C/T cg03678062 chr6:149772716 ZC3H12D 0.28 5.82 0.3 1.35e-8 Dupuytren's disease; LUSC trans rs1005277 0.579 rs2474575 chr10:38387901 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg22143856 chr6:28129313 ZNF389 0.43 5.94 0.31 7.28e-9 Parkinson's disease; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg18099408 chr3:52552593 STAB1 -0.4 -6.85 -0.35 3.62e-11 Bipolar disorder; LUSC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.17 0.45 5.01e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs9311676 0.609 rs62258077 chr3:58363371 T/C cg26110898 chr3:58419937 PDHB 0.41 6.64 0.34 1.29e-10 Systemic lupus erythematosus; LUSC trans rs11098499 0.739 rs10013032 chr4:120149419 C/T cg25214090 chr10:38739885 LOC399744 -0.41 -6.22 -0.32 1.52e-9 Corneal astigmatism; LUSC cis rs9399135 0.935 rs4445070 chr6:135309212 C/T cg24558204 chr6:135376177 HBS1L 0.57 8.72 0.43 1.3e-16 Red blood cell count; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.56 9.55 0.46 2.89e-19 Lymphocyte counts; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01898370 chr4:1283560 MAEA -0.42 -6.14 -0.32 2.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6693567 0.545 rs1694380 chr1:150292341 A/G cg15654264 chr1:150340011 RPRD2 0.45 7.27 0.37 2.62e-12 Migraine; LUSC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg18681998 chr4:17616180 MED28 0.86 16.47 0.67 5.09e-45 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg14829155 chr15:31115871 NA 0.71 10.73 0.51 2.8e-23 Huntington's disease progression; LUSC cis rs4363385 0.626 rs1108410 chr1:153005662 T/C cg00922841 chr1:152955080 SPRR1A -0.39 -6.46 -0.33 3.67e-10 Inflammatory skin disease; LUSC cis rs34779708 0.931 rs3740083 chr10:35320383 C/T cg03585969 chr10:35415529 CREM 0.61 8.82 0.43 6.24e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg26384229 chr12:38710491 ALG10B 0.9 17.22 0.69 5.31e-48 Heart rate; LUSC cis rs10949662 1.000 rs28716556 chr7:157535368 T/C cg11757124 chr7:157526947 PTPRN2 -0.42 -6.24 -0.32 1.3e-9 Intelligence (multi-trait analysis); LUSC cis rs9660992 0.762 rs1172137 chr1:205246061 G/T cg00857998 chr1:205179979 DSTYK 0.51 7.84 0.39 6e-14 Mean corpuscular volume;Mean platelet volume; LUSC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.66 8.81 0.43 6.88e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6840360 0.615 rs12647462 chr4:152607278 C/T cg22705602 chr4:152727874 NA -0.36 -7.87 -0.4 4.89e-14 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg00166722 chr3:10149974 C3orf24 0.59 7.49 0.38 6.02e-13 Alzheimer's disease; LUSC cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg11584989 chr19:19387371 SF4 0.6 7.08 0.36 8.81e-12 Bipolar disorder; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10516465 chr14:102695515 RAGE -0.45 -6.98 -0.36 1.57e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1670533 0.932 rs10902753 chr4:1056223 G/A cg27284194 chr4:1044797 NA 0.6 8.88 0.44 4.09e-17 Recombination rate (females); LUSC cis rs9430161 0.579 rs11121667 chr1:11038476 C/T cg27631724 chr1:11040367 C1orf127 0.55 10.95 0.51 4.6e-24 Ewing sarcoma; LUSC cis rs35146811 0.660 rs3779046 chr7:99779243 A/G cg19116668 chr7:99932089 PMS2L1 -0.33 -5.66 -0.3 3.25e-8 Coronary artery disease; LUSC cis rs7937890 0.874 rs2303972 chr11:14303282 T/A cg22961513 chr11:14280813 SPON1 0.34 5.71 0.3 2.53e-8 Mitochondrial DNA levels; LUSC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg12927641 chr6:109611667 NA -0.43 -7.46 -0.38 7.43e-13 Reticulocyte fraction of red cells; LUSC cis rs7107174 1.000 rs2248407 chr11:77937800 G/A cg02023728 chr11:77925099 USP35 0.5 7.11 0.36 7.29e-12 Testicular germ cell tumor; LUSC cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg24450063 chr1:156163899 SLC25A44 1.18 29.42 0.85 9.33e-95 Testicular germ cell tumor; LUSC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg09034736 chr1:150693464 HORMAD1 0.44 6.04 0.31 4.12e-9 Melanoma; LUSC cis rs8044995 0.563 rs61746794 chr16:68387457 C/T cg05110241 chr16:68378359 PRMT7 -0.83 -9.18 -0.45 4.55e-18 Schizophrenia; LUSC cis rs11025559 1.000 rs11025559 chr11:20443875 A/G cg19653624 chr11:20408972 PRMT3 0.58 6.6 0.34 1.59e-10 Pursuit maintenance gain; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02523415 chr8:82633572 ZFAND1 -0.5 -6.11 -0.32 2.81e-9 Bipolar disorder and schizophrenia; LUSC cis rs208346 0.612 rs208356 chr7:2775825 A/T cg19717773 chr7:2847554 GNA12 0.41 6.63 0.34 1.33e-10 Loneliness (linear analysis); LUSC cis rs1044826 0.619 rs6439856 chr3:139134868 A/T cg00490450 chr3:139108681 COPB2 -0.5 -7.87 -0.4 4.85e-14 Obesity-related traits; LUSC cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg07148914 chr20:33460835 GGT7 0.53 8.27 0.41 3.25e-15 Height; LUSC cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg13010199 chr12:38710504 ALG10B 0.65 9.82 0.47 3.81e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs10871290 0.650 rs28484753 chr16:74489395 G/C cg01733217 chr16:74700730 RFWD3 0.69 10.4 0.49 3.82e-22 Breast cancer; LUSC cis rs2652834 1.000 rs2729830 chr15:63395812 G/C cg05507819 chr15:63340323 TPM1 0.67 8.2 0.41 5.33e-15 HDL cholesterol; LUSC trans rs7824557 0.650 rs2572406 chr8:11092252 C/G cg06636001 chr8:8085503 FLJ10661 0.47 7.33 0.37 1.78e-12 Retinal vascular caliber; LUSC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.81 -0.3 1.48e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs782590 0.967 rs4672054 chr2:55773093 C/A cg18811423 chr2:55921094 PNPT1 0.83 14.55 0.62 1.7e-37 Metabolic syndrome; LUSC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg07741184 chr6:167504864 NA 0.35 6.48 0.33 3.38e-10 Crohn's disease; LUSC cis rs6693567 0.565 rs471657 chr1:150276461 G/A cg15654264 chr1:150340011 RPRD2 -0.47 -7.69 -0.39 1.67e-13 Migraine; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg09080729 chr16:81069740 ATMIN 0.45 6.1 0.32 2.88e-9 Neuroticism; LUSC cis rs1957429 0.808 rs7144718 chr14:65333831 G/A cg23373153 chr14:65346875 NA 0.97 11.0 0.52 3.19e-24 Pediatric areal bone mineral density (radius); LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg06873352 chr17:61820015 STRADA 0.7 12.15 0.55 2.24e-28 Prudent dietary pattern; LUSC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg06008330 chr7:65541103 ASL 0.39 6.14 0.32 2.38e-9 Aortic root size; LUSC cis rs5758511 0.680 rs5758682 chr22:42645202 C/T cg00645731 chr22:42541494 CYP2D7P1 0.57 10.0 0.48 8.88e-21 Birth weight; LUSC cis rs9326248 0.769 rs499910 chr11:116763034 G/A cg11861562 chr11:117069780 TAGLN 0.37 6.42 0.33 4.7e-10 Blood protein levels; LUSC cis rs4700695 0.719 rs27085 chr5:65435063 C/T cg21114390 chr5:65439923 SFRS12 0.63 8.71 0.43 1.43e-16 Facial morphology (factor 19); LUSC cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs34638657 0.752 rs2967374 chr16:82209861 A/G cg09439754 chr16:82129088 HSD17B2 -0.37 -5.65 -0.3 3.42e-8 Lung adenocarcinoma; LUSC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg17366294 chr4:99064904 C4orf37 0.51 8.78 0.43 8.69e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs447735 0.587 rs258336 chr16:89720831 A/C cg04240660 chr16:89714849 CHMP1A -0.43 -6.93 -0.35 2.17e-11 Hemoglobin concentration; LUSC cis rs9875589 0.509 rs2731330 chr3:14111588 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 6.87 0.35 3.21e-11 Ovarian reserve; LUSC cis rs11711311 0.712 rs3773683 chr3:113341007 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.9 -0.31 9.07e-9 IgG glycosylation; LUSC cis rs11971779 0.584 rs7786469 chr7:139094621 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC trans rs28647808 0.881 rs57394597 chr9:136261030 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs2637266 0.935 rs6480822 chr10:78354092 A/C cg18941641 chr10:78392320 NA 0.39 7.26 0.37 2.75e-12 Pulmonary function; LUSC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg23034840 chr1:205782522 SLC41A1 0.63 9.15 0.45 5.67e-18 Menarche (age at onset); LUSC trans rs853679 0.882 rs4713140 chr6:28097193 C/T cg01620082 chr3:125678407 NA -0.57 -6.53 -0.34 2.51e-10 Depression; LUSC cis rs3540 0.597 rs12708583 chr15:91050271 C/T cg03599575 chr15:90893182 GABARAPL3 0.36 6.55 0.34 2.21e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12940923 1.000 rs35433894 chr17:56376042 A/G cg19466818 chr17:56409534 MIR142 -0.38 -6.63 -0.34 1.39e-10 Circulating myeloperoxidase levels (plasma); LUSC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg10664184 chr19:17420304 DDA1 -0.46 -6.04 -0.31 4.2e-9 Systemic lupus erythematosus; LUSC cis rs72781680 0.756 rs2712059 chr2:24020539 T/C cg08917208 chr2:24149416 ATAD2B 0.6 6.91 0.35 2.44e-11 Lymphocyte counts; LUSC cis rs9810089 0.814 rs864437 chr3:136119909 C/G cg12473912 chr3:136751656 NA 0.36 5.91 0.31 8.41e-9 Gestational age at birth (child effect); LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg00166722 chr3:10149974 C3orf24 0.6 8.26 0.41 3.38e-15 Alzheimer's disease; LUSC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg18404041 chr3:52824283 ITIH1 -0.5 -9.53 -0.46 3.33e-19 Bipolar disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26059836 chr10:72575605 SGPL1 -0.42 -6.06 -0.31 3.72e-9 Electrocardiographic conduction measures; LUSC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.33 0.45 1.49e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs61931739 0.534 rs11052957 chr12:33995354 G/A cg26384229 chr12:38710491 ALG10B 0.67 10.53 0.5 1.41e-22 Morning vs. evening chronotype; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg01802117 chr1:53393560 SCP2 -0.45 -7.46 -0.38 7.37e-13 Monocyte count; LUSC cis rs3806843 0.966 rs2563260 chr5:140137867 C/A cg26395211 chr5:140044315 WDR55 0.38 5.84 0.3 1.21e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs981844 1.000 rs1371161 chr4:154655171 T/C cg14289246 chr4:154710475 SFRP2 0.5 6.25 0.32 1.28e-9 Response to statins (LDL cholesterol change); LUSC cis rs12545109 0.800 rs973548 chr8:57416402 C/T cg09654669 chr8:57350985 NA -0.58 -8.12 -0.41 9.15e-15 Obesity-related traits; LUSC cis rs735539 0.574 rs10870743 chr13:21258756 C/A cg04906043 chr13:21280425 IL17D -0.43 -6.72 -0.34 7.99e-11 Dental caries; LUSC cis rs1448094 0.737 rs10863135 chr12:86382657 C/T cg00310523 chr12:86230176 RASSF9 0.37 6.77 0.35 5.98e-11 Major depressive disorder; LUSC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg07959070 chr22:50026188 C22orf34 -0.37 -7.52 -0.38 5e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08109568 chr15:31115862 NA -0.58 -8.15 -0.41 7.28e-15 Huntington's disease progression; LUSC cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg22117172 chr7:91764530 CYP51A1 0.32 5.71 0.3 2.49e-8 Breast cancer; LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs12681287 0.570 rs10956830 chr8:87430483 T/A cg27223183 chr8:87520930 FAM82B 0.54 7.45 0.38 7.84e-13 Caudate activity during reward; LUSC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg20406979 chr6:167373233 NA -0.26 -6.27 -0.32 1.1e-9 Crohn's disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg15849282 chr3:38537770 EXOG -0.42 -6.18 -0.32 1.86e-9 Hepatitis; LUSC cis rs7917772 0.560 rs3862030 chr10:104327584 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg12658694 chr1:38397304 INPP5B 0.43 6.48 0.33 3.24e-10 Coronary artery disease; LUSC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.52 -8.99 -0.44 1.92e-17 Menopause (age at onset); LUSC cis rs1858037 0.867 rs964505 chr2:65623189 G/A cg08085232 chr2:65598271 SPRED2 -0.42 -6.15 -0.32 2.19e-9 Rheumatoid arthritis; LUSC cis rs722599 0.748 rs17093914 chr14:75363641 A/G cg08847533 chr14:75593920 NEK9 0.46 6.46 0.33 3.69e-10 IgG glycosylation; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg00166722 chr3:10149974 C3orf24 0.58 7.42 0.38 9.7e-13 Alzheimer's disease; LUSC trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2115536 0.967 rs4778734 chr15:80210851 A/G cg00225070 chr15:80189496 MTHFS 0.63 9.68 0.47 1.05e-19 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg05043794 chr9:111880884 C9orf5 -0.34 -7.09 -0.36 8.09e-12 Menarche (age at onset); LUSC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.84 0.35 3.76e-11 Intelligence (multi-trait analysis); LUSC cis rs16912285 0.591 rs12796137 chr11:24364459 T/G ch.11.24196551F chr11:24239977 NA 0.77 8.35 0.42 1.9e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg19774624 chr17:42201019 HDAC5 0.65 9.37 0.46 1.1e-18 Total body bone mineral density; LUSC cis rs2439831 0.850 rs28564774 chr15:44125475 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.74 0.35 7.17e-11 Lung cancer in ever smokers; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg00166722 chr3:10149974 C3orf24 0.61 8.64 0.43 2.44e-16 Alzheimer's disease; LUSC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg11812906 chr14:75593930 NEK9 -0.63 -10.29 -0.49 9.29e-22 Height; LUSC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg04317338 chr11:64019027 PLCB3 0.68 7.75 0.39 1.12e-13 Mean platelet volume; LUSC cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs34172651 0.917 rs12599173 chr16:24823619 T/C cg00339695 chr16:24857497 SLC5A11 0.35 6.24 0.32 1.34e-9 Intelligence (multi-trait analysis); LUSC cis rs4631830 0.900 rs9787697 chr10:51533376 C/T cg10326726 chr10:51549505 MSMB -0.38 -6.57 -0.34 1.93e-10 Prostate-specific antigen levels; LUSC cis rs7647973 0.626 rs35129566 chr3:49866584 T/G cg13072238 chr3:49761600 GMPPB 0.68 8.73 0.43 1.21e-16 Menarche (age at onset); LUSC cis rs240764 0.687 rs239209 chr6:101140977 T/C cg09795085 chr6:101329169 ASCC3 0.41 5.93 0.31 7.56e-9 Neuroticism; LUSC cis rs1113500 0.862 rs3853494 chr1:108637334 G/A cg06207961 chr1:108661230 NA 0.41 7.57 0.38 3.61e-13 Growth-regulated protein alpha levels; LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg22001924 chr5:162887193 HMMR;NUDCD2 0.71 6.73 0.35 7.51e-11 Cognitive performance; LUSC cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.56e-13 Motion sickness; LUSC cis rs56399783 0.901 rs17300022 chr7:2808517 C/T cg14895029 chr7:2775587 GNA12 -0.52 -6.23 -0.32 1.4e-9 Childhood ear infection; LUSC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg06484146 chr7:12443880 VWDE -0.68 -7.26 -0.37 2.76e-12 Coronary artery disease; LUSC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.43 -7.97 -0.4 2.45e-14 Monocyte percentage of white cells; LUSC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg17971929 chr21:40555470 PSMG1 -0.69 -11.27 -0.52 3.43e-25 Cognitive function; LUSC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg08975724 chr8:8085496 FLJ10661 0.55 8.66 0.43 2.09e-16 Mood instability; LUSC cis rs3857536 0.813 rs4710581 chr6:66939954 T/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg00033643 chr7:134001901 SLC35B4 0.43 6.6 0.34 1.65e-10 Mean platelet volume; LUSC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg13298116 chr11:62369859 EML3;MTA2 0.59 9.64 0.47 1.43e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11758351 0.715 rs75390741 chr6:26209784 A/T cg23601095 chr6:26197514 HIST1H3D 0.7 7.47 0.38 7.17e-13 Gout;Renal underexcretion gout; LUSC cis rs367943 0.901 rs463167 chr5:112799369 C/A cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs2011503 0.941 rs7257875 chr19:19372150 C/T cg11584989 chr19:19387371 SF4 0.6 7.33 0.37 1.78e-12 Bipolar disorder; LUSC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg13206674 chr6:150067644 NUP43 0.62 10.17 0.49 2.43e-21 Lung cancer; LUSC cis rs7481584 0.624 rs436580 chr11:3063961 T/G cg05729581 chr11:3078854 CARS 0.39 5.68 0.3 2.96e-8 Calcium levels; LUSC trans rs2727020 0.658 rs7120136 chr11:49384358 A/C cg03929089 chr4:120376271 NA -0.99 -16.85 -0.68 1.54e-46 Coronary artery disease; LUSC cis rs9677476 0.863 rs13423632 chr2:232079116 T/C cg07929768 chr2:232055508 NA 0.36 6.83 0.35 4.13e-11 Food antigen IgG levels; LUSC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg14668632 chr7:2872130 GNA12 -0.46 -6.56 -0.34 2e-10 Height; LUSC cis rs9311676 0.656 rs11708895 chr3:58403042 T/C cg26110898 chr3:58419937 PDHB 0.39 6.3 0.33 9.58e-10 Systemic lupus erythematosus; LUSC cis rs2839186 0.967 rs2839191 chr21:47695395 C/G cg13126279 chr21:47581558 C21orf56 -0.43 -6.3 -0.33 9.53e-10 Testicular germ cell tumor; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg11965913 chr1:205819406 PM20D1 0.96 20.06 0.74 2.79e-59 Menarche (age at onset); LUSC cis rs2625529 0.586 rs7173626 chr15:72186926 C/A cg16672083 chr15:72433130 SENP8 0.47 7.67 0.39 1.84e-13 Red blood cell count; LUSC cis rs7527798 0.592 rs6667118 chr1:207822724 G/T cg09232269 chr1:207846808 CR1L -0.3 -6.46 -0.33 3.78e-10 Erythrocyte sedimentation rate; LUSC cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg08564027 chr20:61660810 NA 0.8 11.81 0.54 3.8e-27 Prostate cancer (SNP x SNP interaction); LUSC cis rs7586879 0.559 rs13387729 chr2:25076126 A/G cg01884057 chr2:25150051 NA 0.4 8.93 0.44 2.93e-17 Body mass index; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg14092988 chr3:52407081 DNAH1 0.31 6.08 0.32 3.37e-9 Bipolar disorder; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg04224864 chr1:179851825 TOR1AIP1 0.53 6.17 0.32 2.01e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg12165864 chr7:66369176 NA 0.49 6.57 0.34 1.95e-10 Corneal structure; LUSC cis rs478304 0.934 rs537786 chr11:65494987 C/T cg05805236 chr11:65401703 PCNXL3 0.41 6.85 0.35 3.63e-11 Acne (severe); LUSC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg24399712 chr22:39784796 NA -0.63 -11.44 -0.53 8.7e-26 Intelligence (multi-trait analysis); LUSC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg09323728 chr8:95962352 TP53INP1 0.37 7.22 0.37 3.6e-12 Type 2 diabetes; LUSC cis rs7605827 0.930 rs7571679 chr2:15596603 C/T cg19274914 chr2:15703543 NA 0.47 8.98 0.44 2.02e-17 Educational attainment (years of education); LUSC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg01879757 chr17:41196368 BRCA1 -0.46 -6.97 -0.36 1.72e-11 Menopause (age at onset); LUSC cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg24558204 chr6:135376177 HBS1L 0.65 9.81 0.47 3.81e-20 Red blood cell count; LUSC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg15557168 chr22:42548783 NA -0.47 -7.65 -0.39 2.21e-13 Schizophrenia; LUSC cis rs523522 0.962 rs7471 chr12:120941215 T/C cg12219531 chr12:120966889 COQ5 0.61 8.09 0.4 1.1e-14 High light scatter reticulocyte count; LUSC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg11812906 chr14:75593930 NEK9 -0.65 -10.52 -0.5 1.55e-22 Height; LUSC cis rs6121246 0.821 rs115585940 chr20:30317902 T/C cg13852791 chr20:30311386 BCL2L1 0.97 12.55 0.57 7.08e-30 Mean corpuscular hemoglobin; LUSC cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -7.74 -0.39 1.19e-13 Menarche (age at onset); LUSC cis rs2204008 0.837 rs11168504 chr12:37964922 G/T cg13010199 chr12:38710504 ALG10B 0.69 10.6 0.5 8.32e-23 Bladder cancer; LUSC cis rs7264396 0.561 rs2050930 chr20:34579397 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.6 -0.34 1.57e-10 Total cholesterol levels; LUSC cis rs4631830 0.863 rs4486572 chr10:51531805 A/G cg16070123 chr10:51489643 NA -0.52 -8.15 -0.41 7.51e-15 Prostate-specific antigen levels; LUSC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg13683864 chr3:40499215 RPL14 -1.0 -16.83 -0.68 1.83e-46 Renal cell carcinoma; LUSC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg01879757 chr17:41196368 BRCA1 -0.45 -6.66 -0.34 1.16e-10 Menopause (age at onset); LUSC cis rs7824557 0.767 rs17797443 chr8:11164012 T/C cg21293242 chr8:11204541 TDH 0.32 6.01 0.31 4.95e-9 Retinal vascular caliber; LUSC cis rs9527 0.590 rs1046411 chr10:104837816 G/A cg05855489 chr10:104503620 C10orf26 0.52 7.77 0.39 9.93e-14 Arsenic metabolism; LUSC cis rs2742234 0.541 rs10899786 chr10:43744583 G/A cg15436174 chr10:43711423 RASGEF1A 0.42 6.72 0.34 7.99e-11 Hirschsprung disease; LUSC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg17294928 chr15:75287854 SCAMP5 -0.92 -13.11 -0.58 5.99e-32 Blood trace element (Zn levels); LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18404041 chr3:52824283 ITIH1 -0.62 -12.01 -0.55 7.56e-28 Bipolar disorder; LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg08200582 chr11:442649 ANO9 -0.5 -5.94 -0.31 7.01e-9 Body mass index; LUSC cis rs11295209 1 rs11295209 chr4:120480233 TA/T cg09307838 chr4:120376055 NA -0.48 -7.37 -0.37 1.32e-12 Plateletcrit; LUSC cis rs68170813 0.559 rs5002976 chr7:107050620 C/G cg02696742 chr7:106810147 HBP1 -0.65 -9.36 -0.46 1.25e-18 Coronary artery disease; LUSC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg22535103 chr8:58192502 C8orf71 -0.81 -9.85 -0.47 3e-20 Developmental language disorder (linguistic errors); LUSC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.1 0.32 2.85e-9 Schizophrenia; LUSC cis rs1348850 0.632 rs13008857 chr2:178514468 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.92 0.31 7.84e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2154427 1.000 rs2833963 chr21:34175553 C/T cg21871883 chr21:34145043 C21orf49;C21orf66 0.62 5.96 0.31 6.27e-9 Bilirubin levels; LUSC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.08 -0.32 3.25e-9 Major depressive disorder; LUSC cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg18105134 chr13:113819100 PROZ -0.63 -9.36 -0.46 1.2e-18 Platelet distribution width; LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 6.74 0.35 6.94e-11 Renal function-related traits (BUN); LUSC cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg27286337 chr10:134555280 INPP5A 0.89 11.74 0.54 7.12e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs3733585 0.699 rs6449171 chr4:9965998 C/T cg26043149 chr18:55253948 FECH 0.42 6.34 0.33 7.52e-10 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg04450456 chr4:17643702 FAM184B 0.38 6.21 0.32 1.54e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg14829155 chr15:31115871 NA -0.56 -7.82 -0.39 7.04e-14 Huntington's disease progression; LUSC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg09323728 chr8:95962352 TP53INP1 -0.33 -6.17 -0.32 1.93e-9 Type 2 diabetes; LUSC cis rs7904368 0.754 rs12246217 chr10:16853349 G/C cg14835575 chr10:16859367 RSU1 0.76 9.5 0.46 4.15e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg04944784 chr2:26401820 FAM59B -0.7 -9.79 -0.47 4.49e-20 Gut microbiome composition (summer); LUSC cis rs9840812 0.623 rs1145106 chr3:136111917 G/A cg15507776 chr3:136538369 TMEM22 0.4 5.81 0.3 1.46e-8 Fibrinogen levels; LUSC trans rs6089829 0.962 rs3746747 chr20:61667631 T/C cg13615516 chr5:77269221 NA 0.4 6.69 0.34 9.31e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg18306943 chr3:40428807 ENTPD3 0.4 6.07 0.32 3.44e-9 Renal cell carcinoma; LUSC cis rs7584330 0.737 rs12465714 chr2:238365637 C/T cg14458575 chr2:238380390 NA 0.68 12.06 0.55 4.8e-28 Prostate cancer; LUSC cis rs1559088 0.948 rs12610071 chr19:33582687 A/C cg03563238 chr19:33554763 RHPN2 -0.39 -6.25 -0.32 1.22e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg00166722 chr3:10149974 C3orf24 0.56 7.54 0.38 4.61e-13 Alzheimer's disease; LUSC cis rs11018904 0.817 rs11601793 chr11:89946354 T/G cg26834418 chr11:89957033 CHORDC1 -0.52 -6.24 -0.32 1.32e-9 Intelligence (multi-trait analysis); LUSC cis rs3126085 0.935 rs7533529 chr1:152176871 T/C cg26876637 chr1:152193138 HRNR 0.45 6.39 0.33 5.53e-10 Atopic dermatitis; LUSC cis rs2274273 0.588 rs7158791 chr14:55828607 A/G cg04306507 chr14:55594613 LGALS3 0.49 9.82 0.47 3.79e-20 Protein biomarker; LUSC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg11663144 chr21:46675770 NA -0.41 -7.06 -0.36 9.82e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg25174290 chr11:3078921 CARS 0.6 9.41 0.46 8.29e-19 Longevity; LUSC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.01e-11 Tonsillectomy; LUSC cis rs17255340 0.539 rs1145908 chr6:84014398 C/T cg08257003 chr6:84140564 ME1 -0.31 -7.59 -0.38 3.3e-13 Platelet-derived growth factor BB levels; LUSC cis rs600231 0.708 rs1784100 chr11:65249227 T/C cg17120908 chr11:65337727 SSSCA1 -0.53 -9.32 -0.45 1.58e-18 Bone mineral density; LUSC trans rs60843830 0.964 rs17713568 chr2:242132 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 10.49 0.5 1.91e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19545258 chr7:73703601 CLIP2 -0.44 -5.95 -0.31 6.68e-9 Bipolar disorder and schizophrenia; LUSC cis rs9653442 0.576 rs6542921 chr2:100864498 C/A cg07810366 chr2:100720526 AFF3 -0.38 -6.23 -0.32 1.42e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg16928487 chr17:17741425 SREBF1 -0.37 -7.05 -0.36 1.06e-11 Total body bone mineral density; LUSC trans rs6582630 0.502 rs11181210 chr12:38298069 G/A cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs6126344 0.957 rs6021436 chr20:50405191 G/C cg03643032 chr16:85954903 IRF8 0.3 6.11 0.32 2.71e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs2742417 0.624 rs2742394 chr3:45757591 C/T cg10512202 chr3:45649293 LIMD1 0.36 6.14 0.32 2.33e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg18827107 chr12:86230957 RASSF9 0.42 6.36 0.33 6.46e-10 Major depressive disorder; LUSC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg19318889 chr4:1322082 MAEA 0.57 9.7 0.47 8.91e-20 Longevity; LUSC cis rs870825 0.550 rs59051283 chr4:185646476 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs17102423 0.755 rs884683 chr14:65574482 C/T cg11161011 chr14:65562177 MAX -0.81 -12.19 -0.55 1.57e-28 Obesity-related traits; LUSC cis rs2798269 0.966 rs17679490 chr13:22139291 C/T cg18095732 chr13:22033692 ZDHHC20 -0.4 -6.11 -0.32 2.82e-9 PR segment; LUSC cis rs642803 0.933 rs644740 chr11:65561468 C/T cg27068330 chr11:65405492 SIPA1 0.49 6.53 0.34 2.41e-10 Urate levels; LUSC cis rs926392 0.547 rs6129161 chr20:37678327 T/G cg16355469 chr20:37678765 NA 0.54 7.2 0.37 4.03e-12 Dialysis-related mortality; LUSC cis rs6121246 0.529 rs6060144 chr20:30178624 A/G cg21427119 chr20:30132790 HM13 -0.43 -5.65 -0.3 3.36e-8 Mean corpuscular hemoglobin; LUSC cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg03676636 chr4:99064102 C4orf37 0.27 5.84 0.3 1.24e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs11155671 0.517 rs9397058 chr6:150207249 C/T cg13206674 chr6:150067644 NUP43 0.43 6.56 0.34 2.01e-10 Testicular germ cell tumor; LUSC cis rs9325144 0.647 rs11168741 chr12:38989120 C/T cg13010199 chr12:38710504 ALG10B -0.53 -8.11 -0.41 9.55e-15 Morning vs. evening chronotype; LUSC cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg20908204 chr19:46285434 DMPK -0.46 -8.8 -0.43 7.37e-17 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16786661 chr2:234160315 ATG16L1 -0.54 -7.08 -0.36 8.43e-12 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.826 rs12511640 chr4:120251248 T/C cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs10751667 0.666 rs4074231 chr11:978219 G/C ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.3e-10 Alzheimer's disease (late onset); LUSC cis rs4654899 0.861 rs10916876 chr1:21169996 T/C cg01072550 chr1:21505969 NA 0.48 7.28 0.37 2.44e-12 Superior frontal gyrus grey matter volume; LUSC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg00310523 chr12:86230176 RASSF9 0.45 8.31 0.41 2.43e-15 Major depressive disorder; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg25072359 chr17:41440525 NA 0.65 9.4 0.46 9.16e-19 Menopause (age at onset); LUSC cis rs7618501 1.000 rs2271961 chr3:49878113 C/T cg07274523 chr3:49395745 GPX1 0.37 6.17 0.32 1.94e-9 Intelligence (multi-trait analysis); LUSC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg11965913 chr1:205819406 PM20D1 0.42 5.91 0.31 8.35e-9 Parkinson's disease; LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.85 -0.58 5.64e-31 Platelet count; LUSC trans rs2840044 1.000 rs17637907 chr17:33891386 A/G cg19694781 chr19:47549865 TMEM160 0.56 8.92 0.44 3.09e-17 Response to radiotherapy in cancer (late toxicity); LUSC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg22029157 chr1:209979665 IRF6 0.76 11.23 0.52 4.66e-25 Cleft lip with or without cleft palate; LUSC cis rs7772486 0.748 rs2748484 chr6:146333653 C/T cg23711669 chr6:146136114 FBXO30 0.84 15.12 0.64 9.9e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs6693567 0.565 rs11205371 chr1:150398510 A/G cg15654264 chr1:150340011 RPRD2 0.44 7.09 0.36 8.16e-12 Migraine; LUSC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg25319279 chr11:5960081 NA -0.41 -5.82 -0.3 1.35e-8 DNA methylation (variation); LUSC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg02551604 chr5:131831745 NA 0.45 7.15 0.36 5.61e-12 Asthma (sex interaction); LUSC trans rs12210905 0.925 rs72838258 chr6:27007681 G/A cg11837749 chr1:55047332 ACOT11 0.55 5.96 0.31 6.51e-9 Hip circumference adjusted for BMI; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs72634258 0.945 rs12735338 chr1:8078569 T/C cg26816564 chr1:7831052 VAMP3 0.48 6.15 0.32 2.2e-9 Inflammatory bowel disease; LUSC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg12310025 chr6:25882481 NA 0.6 10.05 0.48 6.13e-21 Blood metabolite levels; LUSC trans rs2018683 0.600 rs717891 chr7:29000374 C/T cg19402173 chr7:128379420 CALU -0.49 -6.66 -0.34 1.1e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs9768139 0.634 rs11762383 chr7:158113889 C/T cg25566285 chr7:158114605 PTPRN2 0.34 6.31 0.33 8.85e-10 Calcium levels; LUSC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -12.34 -0.56 4.47e-29 Hemoglobin concentration; LUSC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC cis rs7605378 1.000 rs7577763 chr2:200681753 C/T cg17644776 chr2:200775616 C2orf69 0.36 5.69 0.3 2.78e-8 Osteoporosis; LUSC cis rs9308433 0.529 rs867444 chr1:214502160 T/C cg06198575 chr1:214491504 SMYD2 0.45 6.95 0.36 1.89e-11 IgG glycosylation; LUSC cis rs593982 0.719 rs11606668 chr11:65472758 A/G cg08755490 chr11:65554678 OVOL1 -0.85 -8.54 -0.42 4.87e-16 Atopic dermatitis; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.42 0.46 7.67e-19 Prudent dietary pattern; LUSC cis rs977987 0.806 rs4888405 chr16:75428196 A/C cg04384234 chr16:75411784 CFDP1 -0.38 -6.17 -0.32 1.98e-9 Dupuytren's disease; LUSC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg13628971 chr7:2884303 GNA12 0.43 6.42 0.33 4.57e-10 Height; LUSC cis rs868036 1.000 rs1026731 chr15:68095018 G/A cg08079166 chr15:68083412 MAP2K5 0.41 8.49 0.42 6.72e-16 Restless legs syndrome; LUSC cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg01028140 chr2:1542097 TPO -0.44 -6.92 -0.35 2.39e-11 IgG glycosylation; LUSC cis rs752010 0.714 rs10789403 chr1:42085869 G/A cg06885757 chr1:42089581 HIVEP3 0.48 10.2 0.49 1.97e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg04944784 chr2:26401820 FAM59B 0.8 11.35 0.53 1.86e-25 Mean corpuscular hemoglobin; LUSC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg27286337 chr10:134555280 INPP5A 0.9 11.66 0.54 1.37e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs243505 0.661 rs887570 chr7:148505255 A/G cg09806900 chr7:148480153 CUL1 0.57 8.44 0.42 1e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg12011299 chr4:100065546 ADH4 0.75 12.36 0.56 3.69e-29 Alcohol dependence; LUSC trans rs1493916 0.721 rs4799723 chr18:31367050 T/G cg15819921 chr19:927150 ARID3A -0.43 -6.45 -0.33 3.99e-10 Life satisfaction; LUSC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.67 0.43 1.96e-16 Motion sickness; LUSC trans rs6502050 0.835 rs8065565 chr17:80115399 A/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs7020830 0.898 rs13290794 chr9:37183628 C/T cg14294708 chr9:37120828 ZCCHC7 1.07 24.31 0.8 7.19e-76 Schizophrenia; LUSC cis rs4595586 0.545 rs6580892 chr12:39370237 G/C cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs826838 0.967 rs826858 chr12:39116731 A/G cg13010199 chr12:38710504 ALG10B -0.63 -10.87 -0.51 9.13e-24 Heart rate; LUSC cis rs6733011 0.578 rs12712038 chr2:99497710 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.09 -0.32 3.18e-9 Bipolar disorder; LUSC cis rs8078723 0.714 rs3859187 chr17:38150613 C/A cg17467752 chr17:38218738 THRA -0.7 -11.27 -0.52 3.54e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs6121246 0.609 rs6060652 chr20:30266845 A/G cg21427119 chr20:30132790 HM13 -0.35 -5.76 -0.3 1.86e-8 Mean corpuscular hemoglobin; LUSC cis rs12950390 0.814 rs11659069 chr17:45834275 G/T cg06532163 chr17:45867833 NA 0.33 6.19 0.32 1.76e-9 IgG glycosylation; LUSC cis rs6964587 1.000 rs4265 chr7:91719608 A/G cg17063962 chr7:91808500 NA -0.6 -9.36 -0.46 1.24e-18 Breast cancer; LUSC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 13.39 0.59 4.97e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4423214 1.000 rs12807718 chr11:71171170 T/C cg05163923 chr11:71159392 DHCR7 0.74 11.0 0.52 3.15e-24 Vitamin D levels; LUSC cis rs360798 0.512 rs6545973 chr2:63089434 C/T cg17519650 chr2:63277830 OTX1 0.48 6.61 0.34 1.54e-10 Coronary artery disease; LUSC trans rs11098499 0.913 rs10006304 chr4:120124305 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.31 0.33 8.83e-10 Corneal astigmatism; LUSC cis rs965469 0.901 rs7270135 chr20:3247922 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -6.22 -0.32 1.5e-9 IFN-related cytopenia; LUSC cis rs12711979 0.509 rs10191674 chr2:3827891 C/T cg17052675 chr2:3827356 NA -0.83 -19.85 -0.74 1.89e-58 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs2274273 0.662 rs4040064 chr14:55678088 G/T cg04306507 chr14:55594613 LGALS3 0.48 9.52 0.46 3.52e-19 Protein biomarker; LUSC cis rs2658782 0.724 rs1563445 chr11:93246042 A/G cg15737290 chr11:93063684 CCDC67 0.61 7.52 0.38 5.17e-13 Pulmonary function decline; LUSC cis rs7223966 1.000 rs6504171 chr17:61710010 G/A cg05941027 chr17:61774174 LIMD2 0.23 6.4 0.33 5.39e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6977660 0.714 rs13230381 chr7:19833896 T/C cg05791153 chr7:19748676 TWISTNB 0.65 6.68 0.34 1e-10 Thyroid stimulating hormone; LUSC cis rs908922 0.651 rs4240885 chr1:152529850 G/C cg20991723 chr1:152506922 NA 0.51 9.6 0.47 1.93e-19 Hair morphology; LUSC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs950027 0.620 rs1153855 chr15:45660758 C/G cg26924012 chr15:45694286 SPATA5L1 0.79 12.5 0.56 1.13e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg20203395 chr5:56204925 C5orf35 0.49 7.3 0.37 2.13e-12 Initial pursuit acceleration; LUSC cis rs11971779 0.616 rs1133068 chr7:139053143 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7582180 0.629 rs11123827 chr2:100951248 C/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15773482 chr3:101395972 ZBTB11;LOC100009676 0.76 6.05 0.31 3.97e-9 Cognitive performance; LUSC cis rs642803 0.591 rs620088 chr11:65508986 G/A cg27068330 chr11:65405492 SIPA1 0.55 7.56 0.38 3.84e-13 Urate levels; LUSC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg22823121 chr1:150693482 HORMAD1 0.59 9.08 0.44 1e-17 Tonsillectomy; LUSC cis rs2346177 0.844 rs4953365 chr2:46644946 G/C cg02822958 chr2:46747628 ATP6V1E2 0.35 5.96 0.31 6.48e-9 HDL cholesterol; LUSC trans rs7939886 0.920 rs11227180 chr11:55855611 G/C cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg24562669 chr7:97807699 LMTK2 0.35 6.25 0.32 1.25e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg11632617 chr15:75315747 PPCDC -0.57 -7.15 -0.36 5.53e-12 Blood trace element (Zn levels); LUSC cis rs7927592 0.913 rs2282563 chr11:68333200 C/T cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.54e-9 Total body bone mineral density; LUSC cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg03146154 chr1:46216737 IPP 0.55 8.34 0.42 1.96e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs778371 0.697 rs2344611 chr2:233581937 A/G cg08000102 chr2:233561755 GIGYF2 0.8 12.63 0.57 3.75e-30 Schizophrenia; LUSC cis rs61931739 0.890 rs1705748 chr12:34133171 A/G cg06521331 chr12:34319734 NA -0.37 -6.31 -0.33 8.65e-10 Morning vs. evening chronotype; LUSC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg04756594 chr16:24857601 SLC5A11 0.48 6.78 0.35 5.37e-11 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg11494091 chr17:61959527 GH2 0.64 13.49 0.59 2.05e-33 Prudent dietary pattern; LUSC cis rs921665 0.831 rs2167961 chr2:3177617 C/G cg02624386 chr2:3182749 NA 0.58 6.43 0.33 4.43e-10 World class endurance athleticism; LUSC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg22823121 chr1:150693482 HORMAD1 0.5 7.32 0.37 1.9e-12 Melanoma; LUSC cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.74 -0.3 2.1e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg22618164 chr12:122356400 WDR66 0.65 9.54 0.46 3.04e-19 Mean corpuscular volume; LUSC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg04756594 chr16:24857601 SLC5A11 0.48 6.82 0.35 4.32e-11 Intelligence (multi-trait analysis); LUSC trans rs2262909 0.962 rs436662 chr19:22232107 C/T cg05197062 chr11:11642011 GALNTL4 -0.56 -7.81 -0.39 7.34e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs11785400 0.762 rs7460801 chr8:143730972 C/A cg24634471 chr8:143751801 JRK 0.51 7.25 0.37 2.97e-12 Schizophrenia; LUSC cis rs9378357 0.702 rs4521639 chr6:3280600 C/G cg08754725 chr6:3293098 SLC22A23 0.52 5.79 0.3 1.66e-8 Obesity-related traits; LUSC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.66 0.47 1.28e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg07636037 chr3:49044803 WDR6 -0.79 -12.14 -0.55 2.42e-28 Menarche (age at onset); LUSC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg08499158 chr17:42289980 UBTF -0.52 -8.7 -0.43 1.54e-16 Total body bone mineral density; LUSC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg03676636 chr4:99064102 C4orf37 0.3 6.6 0.34 1.64e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs10752881 1.000 rs4233192 chr1:182970837 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.7 -11.03 -0.52 2.41e-24 Colorectal cancer; LUSC cis rs2153535 0.869 rs11962457 chr6:8375855 A/T cg07606381 chr6:8435919 SLC35B3 -0.52 -7.73 -0.39 1.27e-13 Motion sickness; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05409435 chr17:41561730 DHX8 0.44 6.35 0.33 6.83e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4810479 0.513 rs3746506 chr20:44586036 G/A cg23252815 chr20:44420276 WFDC3;DNTTIP1 0.36 5.92 0.31 8.04e-9 Metabolite levels; LUSC cis rs2901656 0.934 rs9425311 chr1:172388778 G/T cg03748243 chr1:172413542 C1orf105;PIGC 0.31 6.3 0.33 9.46e-10 Red cell distribution width;Platelet distribution width; LUSC cis rs2692947 0.832 rs2579550 chr2:96741944 G/A cg23100626 chr2:96804247 ASTL 0.3 7.09 0.36 7.8e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7246657 0.943 rs4801803 chr19:37966923 A/G cg23950597 chr19:37808831 NA 0.62 7.42 0.38 9.87e-13 Coronary artery calcification; LUSC cis rs2235544 0.513 rs10158824 chr1:54480398 C/G cg25741118 chr1:54482237 LDLRAD1 0.34 7.67 0.39 1.93e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg09877947 chr5:131593287 PDLIM4 0.44 7.36 0.37 1.46e-12 Blood metabolite levels; LUSC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.77 -0.43 8.98e-17 Gut microbiome composition (summer); LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg08088566 chr11:430123 ANO9 0.61 7.07 0.36 8.89e-12 Body mass index; LUSC cis rs9910055 0.708 rs2631298 chr17:42219832 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.47 8.73 0.43 1.25e-16 Total body bone mineral density; LUSC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg03929089 chr4:120376271 NA -1.03 -19.84 -0.74 2.02e-58 Height; LUSC cis rs7177699 0.550 rs7182103 chr15:79123946 G/T cg00540400 chr15:79124168 NA 0.43 7.5 0.38 5.63e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg13770153 chr20:60521292 NA -0.61 -8.15 -0.41 7.58e-15 Body mass index; LUSC cis rs2486288 0.656 rs11637920 chr15:45550905 T/C cg09092052 chr15:45571596 NA 0.46 6.36 0.33 6.52e-10 Glomerular filtration rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08946801 chr12:100594395 ACTR6 0.41 6.33 0.33 7.85e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6500395 1.000 rs8044519 chr16:48669081 G/T cg04672837 chr16:48644449 N4BP1 0.48 7.11 0.36 7.24e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1865760 0.929 rs2876693 chr6:25954434 C/G cg17691542 chr6:26056736 HIST1H1C 0.48 7.07 0.36 9.02e-12 Height; LUSC cis rs7923609 0.783 rs4746203 chr10:65323997 G/T cg01631684 chr10:65280961 REEP3 0.4 5.85 0.3 1.19e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs4363385 0.510 rs11803710 chr1:153053096 C/G cg25856811 chr1:152973957 SPRR3 -0.37 -6.15 -0.32 2.19e-9 Inflammatory skin disease; LUSC cis rs9814567 0.806 rs2293294 chr3:134322814 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.78 12.58 0.57 5.89e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11645898 0.935 rs11641721 chr16:72155241 G/A cg14768367 chr16:72042858 DHODH -0.63 -7.27 -0.37 2.55e-12 Blood protein levels; LUSC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.59 -0.46 2.18e-19 Chronic sinus infection; LUSC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg03929089 chr4:120376271 NA -1.0 -18.17 -0.71 8.92e-52 Height; LUSC cis rs7020830 0.861 rs13295981 chr9:37330067 C/T cg14294708 chr9:37120828 ZCCHC7 1.09 26.05 0.82 1.98e-82 Schizophrenia; LUSC cis rs7267979 0.565 rs6107059 chr20:25592431 C/A cg03522245 chr20:25566470 NINL -0.4 -6.15 -0.32 2.25e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.65 -10.47 -0.5 2.26e-22 Menarche (age at onset); LUSC trans rs11992162 0.550 rs61426048 chr8:11784956 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.38 -0.33 5.79e-10 Monocyte count; LUSC cis rs6142102 0.961 rs6120519 chr20:32688113 A/G cg08999081 chr20:33150536 PIGU 0.35 5.98 0.31 5.81e-9 Skin pigmentation; LUSC cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.954 rs10518331 chr4:120323595 C/T cg09307838 chr4:120376055 NA 0.78 11.22 0.52 5.18e-25 Corneal astigmatism; LUSC cis rs2522056 1.000 rs2522054 chr5:131799526 G/T cg24060327 chr5:131705240 SLC22A5 0.46 6.17 0.32 1.96e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs5769707 0.521 rs739244 chr22:50060158 A/G cg05373962 chr22:49881684 NA -0.4 -8.71 -0.43 1.43e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs239198 0.568 rs34555037 chr6:101327153 G/C cg09795085 chr6:101329169 ASCC3 0.44 6.37 0.33 6.26e-10 Menarche (age at onset); LUSC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg12016809 chr21:47604291 C21orf56 0.42 6.2 0.32 1.66e-9 Testicular germ cell tumor; LUSC cis rs28595532 0.748 rs17594978 chr4:119336398 T/C cg21605333 chr4:119757512 SEC24D 1.02 8.3 0.41 2.57e-15 Cannabis dependence symptom count; LUSC cis rs7561273 0.545 rs6733127 chr2:24325805 G/A cg08063864 chr2:24346004 PFN4;LOC375190 -0.44 -6.14 -0.32 2.34e-9 Quantitative traits; LUSC cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg03433033 chr1:76189801 ACADM -0.46 -6.98 -0.36 1.64e-11 Daytime sleep phenotypes; LUSC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg06784218 chr1:46089804 CCDC17 0.58 11.41 0.53 1.09e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs739401 0.572 rs404629 chr11:3077025 A/G cg08508325 chr11:3079039 CARS -0.54 -13.57 -0.6 1.07e-33 Longevity; LUSC trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg03929089 chr4:120376271 NA 0.59 6.32 0.33 8.17e-10 Axial length; LUSC cis rs2050392 0.687 rs608693 chr10:30734971 G/A cg18806716 chr10:30721971 MAP3K8 -0.56 -8.95 -0.44 2.52e-17 Inflammatory bowel disease; LUSC cis rs9902453 0.904 rs9900974 chr17:28364456 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.49 -0.5 1.87e-22 Coffee consumption (cups per day); LUSC cis rs868036 0.681 rs3784718 chr15:68098004 C/T cg24579218 chr15:68104479 NA -0.38 -6.8 -0.35 4.93e-11 Restless legs syndrome; LUSC cis rs1160297 0.609 rs6545310 chr2:53103542 T/C cg07782112 chr2:53107842 NA 0.43 7.01 0.36 1.32e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg06454157 chr6:167490870 NA -0.24 -6.04 -0.31 4.19e-9 Crohn's disease; LUSC cis rs60695258 0.512 rs2053769 chr4:87908007 T/C cg10685359 chr4:87814065 C4orf36 0.33 5.81 0.3 1.48e-8 Hematocrit; LUSC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg06494592 chr3:125709126 NA -0.5 -5.77 -0.3 1.86e-8 Blood pressure (smoking interaction); LUSC cis rs929354 0.742 rs62491945 chr7:156955580 G/A cg17757837 chr7:157058334 UBE3C 0.82 13.03 0.58 1.18e-31 Body mass index; LUSC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg13206674 chr6:150067644 NUP43 0.62 9.97 0.48 1.16e-20 Lung cancer; LUSC cis rs7659604 0.521 rs4833773 chr4:122689245 C/T cg20573242 chr4:122745356 CCNA2 -0.42 -6.08 -0.32 3.31e-9 Type 2 diabetes; LUSC cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg00012203 chr2:219082015 ARPC2 -0.77 -13.8 -0.6 1.38e-34 Colorectal cancer; LUSC cis rs1348850 0.560 rs13019660 chr2:178498214 C/T cg22681709 chr2:178499509 PDE11A -0.49 -7.87 -0.4 4.85e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9467711 0.559 rs3799383 chr6:26510748 C/T cg09904177 chr6:26538194 HMGN4 -0.7 -6.46 -0.33 3.79e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg23093090 chr10:104574429 C10orf26 -0.47 -8.34 -0.42 1.96e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4073582 0.595 rs801737 chr11:65928193 T/C cg16950941 chr11:66035639 RAB1B 0.49 7.09 0.36 8.16e-12 Gout; LUSC cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg05729581 chr11:3078854 CARS 0.41 6.05 0.31 3.99e-9 Calcium levels; LUSC cis rs988712 0.622 rs10767664 chr11:27725986 T/A cg10635145 chr11:27742435 BDNF 0.48 6.46 0.33 3.66e-10 Obesity; LUSC trans rs4596713 0.508 rs7862404 chr9:71779903 G/A cg25283916 chr1:242222868 NA -0.29 -6.0 -0.31 5.05e-9 Headache; LUSC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg19302996 chr17:73780495 UNK -0.49 -7.18 -0.37 4.51e-12 White matter hyperintensity burden; LUSC cis rs10392 0.543 rs6028208 chr20:37556075 T/A cg27552599 chr20:37590471 DHX35 0.45 7.37 0.37 1.31e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg08859206 chr1:53392774 SCP2 -0.44 -7.23 -0.37 3.36e-12 Monocyte count; LUSC cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg05985134 chr18:33552581 C18orf21 0.5 7.14 0.36 5.92e-12 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs61931739 0.500 rs9795938 chr12:34587739 C/T cg13010199 chr12:38710504 ALG10B -0.56 -8.82 -0.43 6.69e-17 Morning vs. evening chronotype; LUSC cis rs11792861 0.781 rs11789252 chr9:111762010 A/T cg13535736 chr9:111863775 C9orf5 -0.41 -6.51 -0.34 2.72e-10 Menarche (age at onset); LUSC cis rs2932538 0.922 rs12402929 chr1:113072293 G/C cg22162597 chr1:113214053 CAPZA1 0.73 10.05 0.48 6.32e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7223966 1.000 rs8076717 chr17:61850301 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.48 -6.6 -0.34 1.63e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.17e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs8114671 0.869 rs2038503 chr20:33675900 G/A cg07148914 chr20:33460835 GGT7 -0.45 -6.62 -0.34 1.44e-10 Height; LUSC cis rs1953600 0.715 rs1079242 chr10:81917708 C/T cg00277334 chr10:82204260 NA 0.41 6.35 0.33 7e-10 Sarcoidosis; LUSC cis rs11098499 0.954 rs6820115 chr4:120398182 T/C cg24375607 chr4:120327624 NA 0.69 10.55 0.5 1.22e-22 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20946600 chr2:27294721 LOC100128731 0.44 5.95 0.31 6.61e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg13256891 chr4:100009986 ADH5 0.51 6.97 0.36 1.66e-11 Smoking initiation; LUSC cis rs3916 1.000 rs1799958 chr12:121176083 G/A cg27246729 chr12:121163418 ACADS 0.46 6.69 0.34 9.59e-11 Urinary metabolites (H-NMR features); LUSC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC cis rs11864453 0.647 rs3764311 chr16:72125617 C/G cg01557791 chr16:72042693 DHODH -0.46 -6.84 -0.35 3.81e-11 Fibrinogen levels; LUSC cis rs899997 0.906 rs1809415 chr15:79028201 C/T cg04896959 chr15:78267971 NA -0.55 -10.62 -0.5 6.79e-23 Coronary artery disease or large artery stroke; LUSC cis rs8072100 0.840 rs9893901 chr17:45506682 T/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.85 -0.31 1.15e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs17102423 0.755 rs35769504 chr14:65576857 G/A cg11161011 chr14:65562177 MAX -0.81 -12.26 -0.56 8.99e-29 Obesity-related traits; LUSC cis rs9527 0.545 rs12784384 chr10:104957594 G/C cg23093090 chr10:104574429 C10orf26 -0.34 -6.25 -0.32 1.25e-9 Arsenic metabolism; LUSC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg03188948 chr7:1209495 NA 0.45 6.14 0.32 2.35e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17092148 0.945 rs6060042 chr20:33361721 A/G cg16810054 chr20:33298113 TP53INP2 -0.45 -6.77 -0.35 5.85e-11 Neuroticism; LUSC cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg22753661 chr15:79092743 ADAMTS7 -0.5 -7.13 -0.36 6.34e-12 Diastolic blood pressure; LUSC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.53e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs751728 1.000 rs3806108 chr6:33767579 C/G cg25922239 chr6:33757077 LEMD2 0.54 7.96 0.4 2.75e-14 Crohn's disease; LUSC cis rs80282103 0.764 rs12244052 chr10:1103266 G/A cg18964960 chr10:1102726 WDR37 0.71 6.42 0.33 4.61e-10 Glomerular filtration rate (creatinine); LUSC cis rs9650657 0.615 rs4840519 chr8:10693113 T/C cg27411982 chr8:10470053 RP1L1 -0.36 -5.82 -0.3 1.38e-8 Neuroticism; LUSC cis rs72634258 0.786 rs7524424 chr1:8173369 A/G cg00042356 chr1:8021962 PARK7 0.55 6.76 0.35 6.13e-11 Inflammatory bowel disease; LUSC cis rs4253772 0.872 rs41362646 chr22:46633505 G/A cg09491104 chr22:46646882 C22orf40 -0.63 -6.67 -0.34 1.04e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1018836 0.923 rs6986088 chr8:91538474 A/C cg16814680 chr8:91681699 NA -0.74 -12.49 -0.56 1.25e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4851254 0.920 rs11123808 chr2:100750750 A/C cg07810366 chr2:100720526 AFF3 -0.38 -5.91 -0.31 8.42e-9 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.46 -6.66 -0.34 1.1e-10 Menarche (age at onset); LUSC cis rs4332037 0.950 rs11771828 chr7:1941003 T/C cg23422044 chr7:1970798 MAD1L1 -0.65 -7.32 -0.37 1.84e-12 Bipolar disorder; LUSC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs1670533 0.585 rs6827206 chr4:1065071 A/T cg27284194 chr4:1044797 NA 0.59 9.04 0.44 1.25e-17 Recombination rate (females); LUSC cis rs13191362 0.507 rs7772787 chr6:163190981 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.79 0.47 4.52e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs62238980 0.614 rs78017579 chr22:32381234 T/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs6982240 0.514 rs10095322 chr8:142262327 A/G cg00131261 chr8:142287264 NA -0.36 -6.03 -0.31 4.38e-9 Tonsillectomy; LUSC cis rs10788264 0.652 rs9633732 chr10:124056473 G/T cg09507567 chr10:124027408 NA 0.45 7.53 0.38 4.83e-13 Total body bone mineral density; LUSC cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg05294307 chr14:35346193 BAZ1A -0.5 -6.5 -0.34 2.88e-10 Psoriasis; LUSC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg20243544 chr17:37824526 PNMT 0.38 5.84 0.3 1.21e-8 Self-reported allergy; LUSC cis rs6681460 0.546 rs1998716 chr1:67117106 T/A cg02459107 chr1:67143332 SGIP1 0.45 8.37 0.42 1.56e-15 Presence of antiphospholipid antibodies; LUSC cis rs34779708 0.733 rs7087099 chr10:35541982 C/T cg03585969 chr10:35415529 CREM 0.55 7.61 0.38 2.84e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg00999904 chr2:3704751 ALLC -0.33 -6.04 -0.31 4.16e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg17063962 chr7:91808500 NA 0.59 9.37 0.46 1.15e-18 Breast cancer; LUSC cis rs2249625 0.564 rs2496489 chr6:72877338 G/A cg18830697 chr6:72922368 RIMS1 -0.36 -7.26 -0.37 2.7e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs9788682 0.948 rs34664138 chr15:78831624 T/G cg06917634 chr15:78832804 PSMA4 -0.59 -7.17 -0.37 4.85e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs3808502 0.549 rs1382563 chr8:11426790 C/G cg27411982 chr8:10470053 RP1L1 0.48 7.66 0.39 2.05e-13 Neuroticism; LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.06 -0.68 2.25e-47 Gut microbiome composition (summer); LUSC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg07414643 chr4:187882934 NA 0.55 10.64 0.5 5.75e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs1775715 0.675 rs2808085 chr10:32148599 C/T cg04359828 chr10:32216031 ARHGAP12 0.41 7.01 0.36 1.31e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs78572108 0.777 rs12475676 chr2:42268975 A/G cg00607755 chr2:42274082 PKDCC 0.35 5.98 0.31 5.72e-9 Total body bone mineral density; LUSC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.44e-10 Extrinsic epigenetic age acceleration; LUSC cis rs394563 0.901 rs448874 chr6:149796967 C/T cg11245181 chr6:149772854 ZC3H12D -0.29 -6.31 -0.33 8.79e-10 Dupuytren's disease; LUSC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg06386533 chr2:46925753 SOCS5 0.44 5.77 0.3 1.86e-8 Height; LUSC cis rs28785552 0.966 rs7247272 chr19:53236331 C/T cg22067481 chr19:53234126 ZNF611 0.47 6.49 0.33 3.13e-10 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg16586182 chr3:47516702 SCAP -0.5 -7.81 -0.39 7.3e-14 Colorectal cancer; LUSC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg22920501 chr2:26401640 FAM59B -0.71 -10.4 -0.49 3.83e-22 Gut microbiome composition (summer); LUSC cis rs4356932 1.000 rs6532156 chr4:76974351 G/A cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs9467711 0.606 rs12174631 chr6:26373150 C/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.81 0.3 1.42e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7769051 0.522 rs6911773 chr6:133128848 T/C cg07930552 chr6:133119739 C6orf192 0.95 8.36 0.42 1.71e-15 Type 2 diabetes nephropathy; LUSC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg27068330 chr11:65405492 SIPA1 -0.46 -6.04 -0.31 4.12e-9 Breast cancer; LUSC cis rs7771547 0.573 rs517890 chr6:36397786 G/C cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC cis rs1595825 1.000 rs61605589 chr2:198876532 T/C cg19156104 chr2:198669113 PLCL1 -0.46 -5.68 -0.3 2.91e-8 Ulcerative colitis; LUSC cis rs34779708 0.966 rs7070427 chr10:35485689 A/T cg04310649 chr10:35416472 CREM -0.4 -6.22 -0.32 1.45e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.96e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg08807101 chr21:30365312 RNF160 -0.73 -12.82 -0.57 7.16e-31 Dental caries; LUSC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg14552801 chr7:65878734 NA -0.45 -6.44 -0.33 4.23e-10 Aortic root size; LUSC trans rs890100 0.900 rs11125633 chr2:56744481 G/A cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.31 -6.1 -0.32 2.96e-9 Gut microbiome composition (summer); LUSC cis rs11997175 0.713 rs4733455 chr8:33651290 C/T ch.8.33884649F chr8:33765107 NA -0.48 -7.72 -0.39 1.36e-13 Body mass index; LUSC cis rs1048238 0.506 rs10927867 chr1:16177285 A/G cg21385522 chr1:16154831 NA 0.56 8.49 0.42 6.77e-16 Systolic blood pressure; LUSC cis rs6121246 0.559 rs6060919 chr20:30331922 A/T cg13852791 chr20:30311386 BCL2L1 0.95 14.9 0.63 7.51e-39 Mean corpuscular hemoglobin; LUSC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg00745463 chr17:30367425 LRRC37B 0.79 8.83 0.44 5.9e-17 Hip circumference adjusted for BMI; LUSC cis rs829883 1.000 rs2908843 chr12:98889332 C/G cg25150519 chr12:98850993 NA -0.64 -9.85 -0.47 2.93e-20 Colorectal adenoma (advanced); LUSC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg18876405 chr7:65276391 NA 0.56 8.89 0.44 3.88e-17 Aortic root size; LUSC cis rs4343996 0.934 rs10261250 chr7:3340187 C/G cg21248987 chr7:3385318 SDK1 0.39 6.62 0.34 1.41e-10 Motion sickness; LUSC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg26597838 chr10:835615 NA 0.99 13.57 0.6 1.01e-33 Eosinophil percentage of granulocytes; LUSC trans rs1908814 0.516 rs7825529 chr8:11794444 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.21 0.41 4.96e-15 Neuroticism; LUSC cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.93 -0.51 5.8e-24 Alzheimer's disease (late onset); LUSC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg15335139 chr3:50242325 SLC38A3 -0.25 -5.64 -0.3 3.57e-8 Body mass index; LUSC cis rs7917772 0.582 rs10786687 chr10:104336994 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2439831 0.867 rs6493085 chr15:43654182 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC trans rs4729127 1.000 rs8180727 chr7:94011085 A/G cg20086523 chr13:52378287 DHRS12 -0.54 -6.09 -0.32 3.06e-9 Intelligence; LUSC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4888262 0.545 rs4072450 chr16:74666634 G/C cg01733217 chr16:74700730 RFWD3 0.78 12.74 0.57 1.44e-30 Testicular germ cell tumor; LUSC cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.64 -0.6 5.38e-34 Chronic sinus infection; LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9902453 0.791 rs62068629 chr17:28187596 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.67 0.47 1.16e-19 Coffee consumption (cups per day); LUSC cis rs7674212 0.772 rs13113099 chr4:103974122 A/G cg16532752 chr4:104119610 CENPE -0.45 -6.23 -0.32 1.42e-9 Type 2 diabetes; LUSC cis rs11051970 0.879 rs2728682 chr12:32580193 G/A cg02745156 chr12:32552066 NA 0.43 7.32 0.37 1.88e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11756438 0.572 rs2798326 chr6:119005226 C/T cg21191810 chr6:118973309 C6orf204 0.33 5.65 0.3 3.45e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.6 0.69 1.6e-49 Chronic sinus infection; LUSC cis rs9733 0.744 rs12126004 chr1:150889877 T/C cg13175981 chr1:150552382 MCL1 0.45 6.29 0.33 9.75e-10 Tonsillectomy; LUSC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.53 -9.59 -0.46 2.16e-19 Electroencephalogram traits; LUSC cis rs77106637 0.929 rs1059000 chr11:72504972 G/C cg03878208 chr11:72483293 STARD10 0.54 6.9 0.35 2.56e-11 Type 2 diabetes; LUSC cis rs11158026 0.603 rs3783646 chr14:55471887 T/C cg04306507 chr14:55594613 LGALS3 0.39 7.22 0.37 3.56e-12 Parkinson's disease; LUSC cis rs8060686 0.641 rs12447931 chr16:68179195 C/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.95 -0.31 6.89e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg22963979 chr7:1858916 MAD1L1 -0.59 -9.33 -0.45 1.56e-18 Bipolar disorder and schizophrenia; LUSC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.08 0.32 3.27e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1493916 0.748 rs7230463 chr18:31309133 G/C cg27147174 chr7:100797783 AP1S1 -0.54 -8.53 -0.42 5.07e-16 Life satisfaction; LUSC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg06713675 chr4:122721982 EXOSC9 -0.46 -8.17 -0.41 6.44e-15 Type 2 diabetes; LUSC cis rs561341 0.739 rs1978116 chr17:30220978 A/C cg13647721 chr17:30228624 UTP6 0.67 7.94 0.4 3.05e-14 Hip circumference adjusted for BMI; LUSC cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -7.62 -0.38 2.62e-13 Bone mineral density; LUSC trans rs4718428 1.000 rs868961 chr7:66437208 G/T cg18876405 chr7:65276391 NA 0.45 6.9 0.35 2.56e-11 Corneal structure; LUSC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg22903471 chr2:27725779 GCKR -0.4 -6.68 -0.34 9.9e-11 Total body bone mineral density; LUSC cis rs11098499 0.954 rs28685688 chr4:120420334 T/C cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs2717559 0.542 rs2585156 chr8:143879795 G/A cg07661805 chr8:143867942 LY6D -0.27 -6.23 -0.32 1.41e-9 Urinary tract infection frequency; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06857516 chr19:48205035 GLTSCR1 -0.74 -6.15 -0.32 2.23e-9 Cognitive performance; LUSC trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg03929089 chr4:120376271 NA 0.82 11.07 0.52 1.75e-24 Coronary artery disease; LUSC cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.33e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs1922233 0.943 rs10009559 chr4:92409889 T/C cg24250684 chr1:219729030 NA -0.33 -6.33 -0.33 8.11e-10 Gut microbiome composition (summer and winter); LUSC cis rs295140 0.605 rs295149 chr2:201175244 A/G cg04283868 chr2:201171347 SPATS2L 0.41 6.13 0.32 2.48e-9 QT interval; LUSC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg21972741 chr5:435613 AHRR 0.33 5.92 0.31 7.94e-9 Cystic fibrosis severity; LUSC cis rs2573652 0.723 rs2573655 chr15:100515709 A/C cg09918751 chr15:100517450 ADAMTS17 -0.51 -9.58 -0.46 2.32e-19 Height; LUSC trans rs7615952 0.932 rs13065725 chr3:125632289 C/A cg07211511 chr3:129823064 LOC729375 -1.22 -19.03 -0.72 3.23e-55 Blood pressure (smoking interaction); LUSC cis rs11039100 0.765 rs35863959 chr11:5834622 T/A cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg00012203 chr2:219082015 ARPC2 -0.77 -13.72 -0.6 2.88e-34 Colorectal cancer; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.42 0.33 4.58e-10 Renal function-related traits (BUN); LUSC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11890956 chr21:40555474 PSMG1 -0.92 -16.7 -0.67 5.83e-46 Cognitive function; LUSC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg13206674 chr6:150067644 NUP43 0.59 9.05 0.44 1.18e-17 Lung cancer; LUSC cis rs240768 0.655 rs240155 chr6:101063213 C/T cg12253828 chr6:101329408 ASCC3 0.83 5.73 0.3 2.27e-8 Economic and political preferences (immigration/crime); LUSC cis rs9611519 0.929 rs11090039 chr22:41496800 G/A cg13813247 chr22:41461852 NA -0.4 -7.14 -0.36 5.69e-12 Neuroticism; LUSC cis rs11608355 0.521 rs6606707 chr12:109830241 T/G cg19025524 chr12:109796872 NA -0.4 -7.31 -0.37 1.98e-12 Neuroticism; LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg06873352 chr17:61820015 STRADA -0.7 -11.94 -0.55 1.36e-27 Prudent dietary pattern; LUSC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg13393036 chr8:95962371 TP53INP1 -0.5 -10.92 -0.51 5.84e-24 Type 2 diabetes; LUSC cis rs9814567 1.000 rs9850015 chr3:134269541 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.68 -0.6 3.86e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg17294928 chr15:75287854 SCAMP5 0.41 5.88 0.31 1e-8 Breast cancer; LUSC cis rs2115630 1.000 rs11854313 chr15:85304048 G/C cg09876464 chr15:85330779 ZNF592 0.38 6.96 0.36 1.81e-11 P wave terminal force; LUSC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg09165964 chr15:75287851 SCAMP5 -1.17 -19.43 -0.73 8.65e-57 Blood trace element (Zn levels); LUSC cis rs6430585 0.528 rs10496738 chr2:136751488 C/T cg07169764 chr2:136633963 MCM6 1.13 17.53 0.69 2.98e-49 Corneal structure; LUSC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg23262073 chr20:60523788 NA 0.47 6.64 0.34 1.25e-10 Body mass index; LUSC cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg12826209 chr6:26865740 GUSBL1 0.76 6.5 0.33 2.98e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7833986 1.000 rs56699713 chr8:57096670 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.58 8.87 0.44 4.64e-17 Height; LUSC cis rs11031096 0.711 rs4910891 chr11:4153408 A/G cg18678763 chr11:4115507 RRM1 -0.53 -7.61 -0.38 2.73e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9888739 0.858 rs60312440 chr16:31340086 C/T cg15817542 chr16:31343056 ITGAM -0.52 -7.01 -0.36 1.33e-11 Systemic lupus erythematosus; LUSC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg22875332 chr1:76189707 ACADM 0.84 15.19 0.64 5.34e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7560272 0.538 rs13006448 chr2:73924424 G/T cg20560298 chr2:73613845 ALMS1 0.39 5.95 0.31 6.69e-9 Schizophrenia; LUSC trans rs4718428 0.705 rs4718422 chr7:66359269 A/G cg18876405 chr7:65276391 NA 0.49 6.71 0.34 8.46e-11 Corneal structure; LUSC cis rs593982 1.000 rs470360 chr11:65500530 T/C cg08755490 chr11:65554678 OVOL1 1.41 17.72 0.7 5.44e-50 Atopic dermatitis; LUSC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg27286337 chr10:134555280 INPP5A 0.92 11.97 0.55 1.05e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9914988 0.943 rs4313850 chr17:27080768 T/C cg19789473 chr17:27170043 C17orf63 -0.31 -5.78 -0.3 1.73e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4925325 0.876 rs6089560 chr20:60517325 T/G cg12751644 chr20:60527061 NA -0.43 -7.41 -0.38 1.07e-12 Obesity-related traits; LUSC trans rs1997103 1.000 rs2331063 chr7:55408914 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs12519773 0.967 rs4242239 chr5:92482226 A/G cg18783429 chr5:92414398 NA 0.32 6.97 0.36 1.72e-11 Migraine; LUSC cis rs929354 0.772 rs1182441 chr7:157026650 A/G cg17757837 chr7:157058334 UBE3C -0.82 -13.33 -0.59 8.54e-33 Body mass index; LUSC cis rs10986311 0.851 rs10818940 chr9:127063459 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.38 5.83 0.3 1.3e-8 Vitiligo; LUSC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.6 -7.47 -0.38 7.29e-13 Lung function (FEV1/FVC); LUSC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg09267113 chr7:98030324 BAIAP2L1 0.39 5.89 0.31 9.63e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 5.84 0.3 1.24e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs240764 0.817 rs239237 chr6:101094940 A/G cg09795085 chr6:101329169 ASCC3 0.42 6.09 0.32 3.09e-9 Neuroticism; LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18404041 chr3:52824283 ITIH1 -0.52 -10.01 -0.48 8.12e-21 Electroencephalogram traits; LUSC cis rs3740713 1.000 rs73440634 chr11:18473546 T/A cg15463284 chr11:18477534 LDHAL6A -0.5 -5.84 -0.3 1.21e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2050392 0.624 rs303436 chr10:30731893 G/T cg25182066 chr10:30743637 MAP3K8 -0.43 -6.29 -0.33 9.9e-10 Inflammatory bowel disease; LUSC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.25 0.49 1.34e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.51e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs9346649 0.606 rs6940383 chr6:168491688 G/A cg02770688 chr6:168491649 NA 0.51 9.72 0.47 7.94e-20 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs6591341 0.515 rs599301 chr11:68189945 G/C cg20283391 chr11:68216788 NA -0.51 -7.09 -0.36 7.92e-12 Lean body mass; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg01802117 chr1:53393560 SCP2 -0.37 -6.32 -0.33 8.28e-10 Monocyte count; LUSC cis rs9300255 0.639 rs1716171 chr12:123716376 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.22 -0.32 1.48e-9 Neutrophil percentage of white cells; LUSC cis rs2970818 0.831 rs4238020 chr12:4616642 C/T cg11146114 chr12:4671731 NA 0.57 6.06 0.31 3.63e-9 Phosphorus levels; LUSC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg20684491 chr1:25596433 NA 0.36 5.83 0.3 1.33e-8 Erythrocyte sedimentation rate; LUSC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg03929089 chr4:120376271 NA -1.03 -19.84 -0.74 2.02e-58 Height; LUSC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.33 0.37 1.8e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10754283 0.934 rs1934043 chr1:90106645 C/T cg21401794 chr1:90099060 LRRC8C 0.65 9.74 0.47 6.91e-20 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs7944735 0.517 rs1827503 chr11:48225115 G/T cg03929089 chr4:120376271 NA 0.67 6.17 0.32 1.97e-9 Intraocular pressure; LUSC trans rs4843747 0.671 rs4072871 chr16:88106614 C/T cg26811252 chr16:29126840 RRN3P2 0.58 9.22 0.45 3.51e-18 Menopause (age at onset); LUSC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg04733989 chr22:42467013 NAGA -0.62 -9.75 -0.47 6.31e-20 Schizophrenia; LUSC cis rs7605827 0.930 rs6431709 chr2:15638296 T/C cg19274914 chr2:15703543 NA 0.47 9.12 0.45 7.34e-18 Educational attainment (years of education); LUSC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg17173187 chr15:85201210 NMB 0.35 7.06 0.36 9.55e-12 P wave terminal force; LUSC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg15448220 chr1:150897856 SETDB1 0.4 5.89 0.31 9.28e-9 Melanoma; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg17178900 chr1:205818956 PM20D1 0.91 16.83 0.68 1.84e-46 Menarche (age at onset); LUSC cis rs7809950 1.000 rs4727680 chr7:107087407 T/G cg23024343 chr7:107201750 COG5 -0.55 -8.76 -0.43 1.01e-16 Coronary artery disease; LUSC trans rs7939886 0.920 rs61887958 chr11:55938234 A/G cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC cis rs6005807 0.719 rs73430179 chr22:28998821 T/C cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs68170813 0.559 rs17350182 chr7:106909637 T/A cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.7 0.39 1.61e-13 Prudent dietary pattern; LUSC trans rs1005277 0.522 rs289650 chr10:37975505 G/T cg17830980 chr10:43048298 ZNF37B -0.39 -6.28 -0.32 1.07e-9 Extrinsic epigenetic age acceleration; LUSC cis rs1499972 0.941 rs73168378 chr3:117636234 G/T cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.95e-8 Schizophrenia; LUSC cis rs7647973 0.925 rs6808036 chr3:49236439 T/G cg07636037 chr3:49044803 WDR6 0.7 9.08 0.44 9.83e-18 Menarche (age at onset); LUSC cis rs240993 0.595 rs3777912 chr6:111902676 T/C cg22127309 chr6:111907043 TRAF3IP2 0.34 6.12 0.32 2.69e-9 Inflammatory skin disease;Psoriasis; LUSC cis rs3087591 0.922 rs11867284 chr17:29597464 G/A cg24425628 chr17:29625626 OMG;NF1 0.56 8.13 0.41 8.47e-15 Hip circumference; LUSC cis rs4363385 0.720 rs1338178 chr1:152981550 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.48e-13 Inflammatory skin disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22159387 chr7:117824075 NAA38 -0.42 -6.26 -0.32 1.16e-9 Electrocardiographic conduction measures; LUSC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg05738196 chr6:26577821 NA 0.53 8.32 0.41 2.23e-15 Schizophrenia; LUSC cis rs2842992 0.714 rs2475564 chr6:160123673 A/G cg11366901 chr6:160182831 ACAT2 0.96 13.04 0.58 1.04e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg15485101 chr11:133734466 NA -0.35 -6.28 -0.33 1.04e-9 Childhood ear infection; LUSC cis rs9902453 0.933 rs9303628 chr17:28527228 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.3 0.45 1.94e-18 Coffee consumption (cups per day); LUSC cis rs7927592 0.513 rs556442 chr11:68192690 G/A cg20283391 chr11:68216788 NA 0.51 7.18 0.37 4.49e-12 Total body bone mineral density; LUSC cis rs7511006 0.895 rs5771270 chr22:50682865 G/A cg07895657 chr22:50616420 PANX2 -0.36 -5.89 -0.31 9.41e-9 Obesity-related traits; LUSC cis rs10782582 0.632 rs11810154 chr1:76239973 C/G cg03433033 chr1:76189801 ACADM -0.39 -5.71 -0.3 2.55e-8 Daytime sleep phenotypes; LUSC cis rs4629710 0.592 rs9492864 chr6:131531306 A/T cg12606694 chr6:131520996 AKAP7 0.62 9.17 0.45 4.95e-18 Multiple myeloma (IgH translocation); LUSC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg06850241 chr22:41845214 NA -0.3 -5.92 -0.31 7.83e-9 Vitiligo; LUSC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg07424592 chr7:64974309 NA 0.69 5.99 0.31 5.45e-9 Diabetic kidney disease; LUSC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg03264133 chr6:25882463 NA 0.39 6.36 0.33 6.57e-10 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10324419 chr4:175205038 FBXO8;KIAA1712 0.37 6.5 0.34 2.96e-10 Triglycerides; LUSC cis rs2219968 1.000 rs13260890 chr8:78970064 G/A cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs4596713 0.568 rs7048937 chr9:71746253 A/G cg25283916 chr1:242222868 NA 0.29 6.01 0.31 4.87e-9 Headache; LUSC trans rs7937682 0.855 rs7109592 chr11:111533105 C/A cg18187862 chr3:45730750 SACM1L 0.55 7.02 0.36 1.26e-11 Primary sclerosing cholangitis; LUSC cis rs3105593 1.000 rs3109894 chr15:50878574 C/T cg08437265 chr15:50716283 USP8 0.4 6.1 0.32 2.86e-9 QT interval; LUSC cis rs6674970 0.932 rs12569193 chr1:151115186 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.44 -5.94 -0.31 7.23e-9 Childhood ear infection; LUSC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.63 -0.34 1.32e-10 Aortic root size; LUSC cis rs7927592 0.956 rs10896341 chr11:68313180 G/A cg20283391 chr11:68216788 NA -0.61 -8.46 -0.42 8.4e-16 Total body bone mineral density; LUSC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg13206674 chr6:150067644 NUP43 0.57 8.91 0.44 3.4e-17 Lung cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03833794 chr17:78190983 SGSH 0.48 6.88 0.35 2.99e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4595586 0.545 rs1607042 chr12:39368028 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg11645453 chr3:52864694 ITIH4 -0.36 -8.25 -0.41 3.81e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.56 0.46 2.75e-19 Prudent dietary pattern; LUSC cis rs7917772 0.582 rs10883736 chr10:104320029 G/T cg05855489 chr10:104503620 C10orf26 -0.48 -7.29 -0.37 2.21e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs1376359 0.537 rs579478 chr1:103255084 G/A cg17154563 chr19:40477487 PSMC4 0.48 6.04 0.31 4.22e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs9479482 1.000 rs11155697 chr6:150357423 C/T cg00432049 chr6:150390894 ULBP3 -0.27 -5.7 -0.3 2.7e-8 Alopecia areata; LUSC cis rs73200209 0.744 rs11614312 chr12:116694851 A/G cg01776926 chr12:116560359 MED13L 0.48 5.79 0.3 1.62e-8 Total body bone mineral density; LUSC cis rs11190604 1.000 rs3793706 chr10:102269085 A/C cg07080220 chr10:102295463 HIF1AN -0.67 -9.33 -0.45 1.47e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg03709012 chr19:19516395 GATAD2A -0.76 -11.96 -0.55 1.14e-27 Tonsillectomy; LUSC cis rs616402 0.527 rs604369 chr1:10567208 C/A cg17425144 chr1:10567563 PEX14 0.64 13.22 0.59 2.22e-32 Breast size; LUSC cis rs7267979 0.966 rs2261785 chr20:25262403 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.74 0.75 5.35e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11585357 0.671 rs2501776 chr1:17619279 C/T cg08277548 chr1:17600880 PADI3 0.47 5.88 0.31 9.75e-9 Hair shape; LUSC cis rs16910800 1.000 rs73479585 chr11:23197391 T/C cg20040320 chr11:23191996 NA -0.45 -6.59 -0.34 1.68e-10 Cancer; LUSC trans rs853679 0.517 rs9368557 chr6:28131537 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs921665 0.749 rs2368682 chr2:3197387 C/T cg02624386 chr2:3182749 NA 0.59 6.6 0.34 1.59e-10 World class endurance athleticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06005309 chr2:202316239 STRADB;TRAK2 0.44 6.31 0.33 8.85e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72781680 0.898 rs72782137 chr2:24047805 C/T cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs8180040 0.726 rs4682837 chr3:46999707 C/T cg02527881 chr3:46936655 PTH1R -0.41 -7.36 -0.37 1.42e-12 Colorectal cancer; LUSC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg11645453 chr3:52864694 ITIH4 0.34 7.95 0.4 2.82e-14 Bipolar disorder; LUSC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg16434002 chr17:42200994 HDAC5 0.44 5.86 0.31 1.12e-8 Total body bone mineral density; LUSC trans rs11992162 0.636 rs4841645 chr8:11798684 G/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.95 -0.36 1.93e-11 Monocyte count; LUSC trans rs7660760 1.000 rs7662146 chr4:177530793 C/T cg14630032 chr3:148898124 CP -0.25 -5.97 -0.31 6.13e-9 Left ventricle wall thickness; LUSC cis rs1577917 0.958 rs7453105 chr6:86500761 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.82 -0.35 4.34e-11 Response to antipsychotic treatment; LUSC cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg04990556 chr1:26633338 UBXN11 -0.46 -6.11 -0.32 2.7e-9 Granulocyte percentage of myeloid white cells; LUSC trans rs877282 0.838 rs11253373 chr10:774857 A/G cg13042288 chr15:90349979 ANPEP -0.49 -6.93 -0.35 2.17e-11 Uric acid levels; LUSC cis rs738322 1.000 rs133009 chr22:38569653 G/C cg17652424 chr22:38574118 PLA2G6 -0.3 -6.51 -0.34 2.69e-10 Cutaneous nevi; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.71 10.68 0.5 4.34e-23 Lymphocyte counts; LUSC cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg06028605 chr16:24865363 SLC5A11 0.51 9.0 0.44 1.77e-17 Intelligence (multi-trait analysis); LUSC cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg11266682 chr4:10021025 SLC2A9 0.58 10.63 0.5 6.51e-23 Bone mineral density; LUSC cis rs3858526 0.834 rs7116627 chr11:5985550 T/C cg13902645 chr11:5959945 NA -0.62 -8.6 -0.43 3.19e-16 DNA methylation (variation); LUSC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg11752832 chr7:134001865 SLC35B4 0.59 9.23 0.45 3.21e-18 Mean platelet volume; LUSC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.27 -0.45 2.39e-18 Monocyte percentage of white cells; LUSC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg05872129 chr22:39784769 NA -0.61 -11.08 -0.52 1.59e-24 Intelligence (multi-trait analysis); LUSC cis rs10266483 0.921 rs653746 chr7:63744777 T/C cg24201672 chr7:64023550 ZNF680 -0.43 -5.66 -0.3 3.2e-8 Response to statin therapy; LUSC trans rs11148252 0.514 rs1886539 chr13:52726090 C/T cg18335740 chr13:41363409 SLC25A15 0.48 6.9 0.35 2.58e-11 Lewy body disease; LUSC cis rs7746199 0.736 rs13215275 chr6:27647509 G/T cg26958806 chr6:27640298 NA 0.75 6.01 0.31 4.76e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9611519 0.929 rs4821991 chr22:41440683 T/C cg03806693 chr22:41940476 POLR3H -0.54 -7.3 -0.37 2.11e-12 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21005948 chr18:46065258 KIAA0427 -0.55 -7.22 -0.37 3.47e-12 Bipolar disorder and schizophrenia; LUSC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg04871131 chr7:94954202 PON1 -0.38 -6.12 -0.32 2.65e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg00310523 chr12:86230176 RASSF9 0.52 9.79 0.47 4.67e-20 Major depressive disorder; LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg00684032 chr4:1343700 KIAA1530 0.33 5.71 0.3 2.5e-8 Obesity-related traits; LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 11.95 0.55 1.2e-27 Platelet count; LUSC cis rs9611519 1.000 rs6002271 chr22:41566595 C/T cg03806693 chr22:41940476 POLR3H -0.57 -7.86 -0.39 5.5e-14 Neuroticism; LUSC cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg22676075 chr6:135203613 NA 0.58 9.21 0.45 3.6e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs8018808 0.935 rs4899654 chr14:77867314 A/C cg18872420 chr14:78023429 SPTLC2 0.36 5.73 0.3 2.2e-8 Myeloid white cell count; LUSC cis rs921665 1.000 rs7581068 chr2:3178831 T/C cg16434511 chr2:3151078 NA -0.53 -5.92 -0.31 8.05e-9 World class endurance athleticism; LUSC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg01097406 chr16:89675127 NA 0.46 9.3 0.45 1.96e-18 Vitiligo; LUSC cis rs5758659 1.000 rs5758659 chr22:42622003 C/T cg05082376 chr22:42548792 NA -0.42 -7.04 -0.36 1.11e-11 Cognitive function; LUSC cis rs7267979 1.000 rs2500432 chr20:25290512 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.32 0.67 1.91e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg22029157 chr1:209979665 IRF6 0.72 10.71 0.51 3.31e-23 Cleft lip with or without cleft palate; LUSC cis rs12545109 0.842 rs2609975 chr8:57401667 T/C cg09654669 chr8:57350985 NA -0.52 -6.75 -0.35 6.57e-11 Obesity-related traits; LUSC cis rs9644630 1.000 rs4921657 chr8:19370867 C/G cg01280390 chr8:19363452 CSGALNACT1 0.33 6.06 0.31 3.62e-9 Oropharynx cancer; LUSC cis rs8017423 0.934 rs11159952 chr14:90684874 T/C cg14092571 chr14:90743983 NA -0.36 -5.99 -0.31 5.48e-9 Mortality in heart failure; LUSC cis rs7582180 0.614 rs6737217 chr2:101006267 T/G cg12002119 chr2:101014098 CHST10 0.37 6.27 0.32 1.12e-9 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 11.99 0.55 8.38e-28 Platelet count; LUSC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg21665744 chr7:39171113 POU6F2 0.43 6.66 0.34 1.11e-10 IgG glycosylation; LUSC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.79e-9 Crohn's disease;Inflammatory bowel disease; LUSC trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg25482853 chr8:67687455 SGK3 1.2 17.05 0.68 2.38e-47 Lung disease severity in cystic fibrosis; LUSC cis rs1994135 0.617 rs12821909 chr12:33723466 T/C cg06521331 chr12:34319734 NA -0.4 -5.73 -0.3 2.26e-8 Resting heart rate; LUSC cis rs2274273 0.901 rs68046603 chr14:55762803 T/A cg04306507 chr14:55594613 LGALS3 0.54 12.17 0.55 1.88e-28 Protein biomarker; LUSC cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg01304814 chr3:48885189 PRKAR2A 0.85 5.97 0.31 6.12e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg24829409 chr8:58192753 C8orf71 -0.48 -5.89 -0.31 9.28e-9 Developmental language disorder (linguistic errors); LUSC cis rs929354 0.772 rs1182448 chr7:157021415 G/A cg05182265 chr7:156933206 UBE3C 0.6 9.74 0.47 6.75e-20 Body mass index; LUSC cis rs6800768 0.663 rs7428009 chr3:24094151 A/C cg10674438 chr3:24145617 LOC152024 -0.41 -6.4 -0.33 5.21e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs734999 0.545 rs3890745 chr1:2553624 C/T cg18854424 chr1:2615690 NA -0.49 -9.93 -0.48 1.54e-20 Ulcerative colitis; LUSC cis rs7945718 0.967 rs10765989 chr11:12769397 A/G cg25843174 chr11:12811716 TEAD1 -0.31 -6.98 -0.36 1.58e-11 Educational attainment (years of education); LUSC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg03709012 chr19:19516395 GATAD2A 0.87 14.83 0.63 1.38e-38 Tonsillectomy; LUSC cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg11584989 chr19:19387371 SF4 0.64 7.2 0.37 3.92e-12 Bipolar disorder; LUSC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg20573242 chr4:122745356 CCNA2 -0.44 -6.87 -0.35 3.23e-11 Type 2 diabetes; LUSC trans rs617791 0.530 rs55947178 chr11:65754230 G/A cg17712092 chr4:129076599 LARP1B -0.73 -10.28 -0.49 9.91e-22 Breast cancer; LUSC cis rs701145 0.585 rs938989 chr3:153788222 A/G cg17054900 chr3:154042577 DHX36 0.75 6.32 0.33 8.21e-10 Coronary artery disease; LUSC cis rs10193935 1.000 rs10195776 chr2:42425098 G/A cg27598129 chr2:42591480 NA -0.64 -8.64 -0.43 2.28e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC cis rs11098499 0.789 rs9991166 chr4:120237851 G/A cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs8060686 0.641 rs73612222 chr16:68216072 A/G cg05110241 chr16:68378359 PRMT7 -0.56 -6.31 -0.33 9.05e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9515201 0.787 rs9521734 chr13:111037289 A/T cg05272587 chr13:111038400 COL4A2 -0.37 -6.05 -0.31 3.8e-9 White matter hyperintensity burden; LUSC cis rs868036 0.718 rs8025790 chr15:68076399 G/T cg05925327 chr15:68127851 NA -0.43 -6.93 -0.35 2.22e-11 Restless legs syndrome; LUSC cis rs1451375 0.527 rs6950777 chr7:50597056 G/A cg18232548 chr7:50535776 DDC 0.55 7.74 0.39 1.17e-13 Malaria; LUSC cis rs701145 0.585 rs1629659 chr3:153798731 C/T cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs6681460 0.898 rs1032634 chr1:67195192 C/G cg02459107 chr1:67143332 SGIP1 -0.46 -8.6 -0.43 3.16e-16 Presence of antiphospholipid antibodies; LUSC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg15448220 chr1:150897856 SETDB1 -0.4 -6.04 -0.31 4.06e-9 Melanoma; LUSC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg04155289 chr7:94953770 PON1 -0.34 -5.77 -0.3 1.77e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs7615952 0.641 rs66520539 chr3:125780374 G/A cg07211511 chr3:129823064 LOC729375 -0.74 -9.59 -0.46 2.12e-19 Blood pressure (smoking interaction); LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg26338869 chr17:61819248 STRADA 0.41 5.87 0.31 1.05e-8 Prudent dietary pattern; LUSC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg23172400 chr8:95962367 TP53INP1 -0.3 -5.81 -0.3 1.49e-8 Type 2 diabetes; LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.34 0.56 4.44e-29 Prudent dietary pattern; LUSC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg23436779 chr17:56769830 TEX14;RAD51C -0.47 -5.99 -0.31 5.49e-9 Cognitive test performance; LUSC cis rs7712401 0.791 rs4835897 chr5:122121504 C/G cg19077854 chr5:122220652 SNX24 0.33 7.29 0.37 2.2e-12 Mean platelet volume; LUSC cis rs17828380 0.920 rs12902541 chr15:63615016 T/C cg05507819 chr15:63340323 TPM1 -0.76 -6.13 -0.32 2.46e-9 Social communication problems; LUSC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.24e-10 Aortic root size; LUSC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg16434002 chr17:42200994 HDAC5 0.43 5.74 0.3 2.12e-8 Total body bone mineral density; LUSC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg11812906 chr14:75593930 NEK9 -0.64 -10.65 -0.5 5.18e-23 Height; LUSC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg06238570 chr21:40685208 BRWD1 -0.54 -8.41 -0.42 1.18e-15 Menarche (age at onset); LUSC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.527 rs12946522 chr17:56768103 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.81 12.23 0.56 1.09e-28 Cognitive test performance; LUSC cis rs9399401 0.961 rs2050157 chr6:142658162 C/T cg03128060 chr6:142623767 GPR126 0.31 5.68 0.3 2.96e-8 Chronic obstructive pulmonary disease; LUSC cis rs7843479 0.601 rs727693 chr8:21850116 A/G cg17168535 chr8:21777572 XPO7 0.84 15.26 0.64 2.93e-40 Mean corpuscular volume; LUSC cis rs4363385 0.574 rs6671520 chr1:152944156 C/T cg00922841 chr1:152955080 SPRR1A -0.36 -6.05 -0.31 3.88e-9 Inflammatory skin disease; LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC trans rs853679 0.607 rs35902873 chr6:28058949 G/C cg06606381 chr12:133084897 FBRSL1 -1.05 -9.22 -0.45 3.34e-18 Depression; LUSC cis rs6060960 0.502 rs6057968 chr20:30082779 A/T cg18721089 chr20:30220636 NA -0.39 -6.34 -0.33 7.33e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs4332037 0.901 rs7791899 chr7:1935988 T/C cg10840412 chr1:235813424 GNG4 0.67 8.97 0.44 2.19e-17 Bipolar disorder; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg25767906 chr1:53392781 SCP2 -0.51 -9.52 -0.46 3.54e-19 Monocyte count; LUSC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg14298792 chr15:30685198 CHRFAM7A -0.69 -8.93 -0.44 2.94e-17 Huntington's disease progression; LUSC cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg18132916 chr6:79620363 NA -0.37 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs4820294 0.961 rs62236664 chr22:38059427 T/C cg21798802 chr22:38057573 PDXP 0.48 10.54 0.5 1.25e-22 Fat distribution (HIV); LUSC trans rs12677056 0.735 rs72672881 chr8:113300247 G/A cg12159992 chr12:102059490 MYBPC1 0.36 6.03 0.31 4.3e-9 Peripheral artery disease; LUSC cis rs12220238 1.000 rs9665468 chr10:75938838 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.57 6.84 0.35 3.84e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg26314531 chr2:26401878 FAM59B -0.7 -9.6 -0.47 1.92e-19 Gut microbiome composition (summer); LUSC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg05234568 chr11:5960015 NA -0.57 -8.51 -0.42 5.84e-16 DNA methylation (variation); LUSC cis rs11122272 0.701 rs2486725 chr1:231540288 G/C cg06096015 chr1:231504339 EGLN1 0.56 9.73 0.47 7.59e-20 Hemoglobin concentration; LUSC cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg07148914 chr20:33460835 GGT7 0.53 8.26 0.41 3.47e-15 Height; LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 6.66 0.34 1.13e-10 Platelet count; LUSC cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg20476274 chr7:133979776 SLC35B4 0.8 13.27 0.59 1.42e-32 Mean platelet volume; LUSC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg23711669 chr6:146136114 FBXO30 0.9 17.2 0.69 6.1e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs1997103 1.000 rs6968966 chr7:55411356 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9815354 0.951 rs9850310 chr3:41891098 T/C cg03022575 chr3:42003672 ULK4 0.63 6.85 0.35 3.49e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs7177699 0.581 rs7181432 chr15:79123779 C/T cg00540400 chr15:79124168 NA 0.43 7.5 0.38 5.63e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7246657 0.943 rs1382357 chr19:37977609 G/A cg23950597 chr19:37808831 NA -0.64 -7.65 -0.39 2.23e-13 Coronary artery calcification; LUSC cis rs6121246 0.697 rs6088856 chr20:30226543 C/G cg18721089 chr20:30220636 NA -0.4 -6.56 -0.34 2.03e-10 Mean corpuscular hemoglobin; LUSC trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg15704280 chr7:45808275 SEPT13 -0.76 -9.6 -0.47 2.01e-19 Coronary artery disease; LUSC cis rs7592578 0.771 rs62181034 chr2:191354963 C/A cg10560079 chr2:191398806 TMEM194B -0.71 -8.6 -0.43 3.09e-16 Diastolic blood pressure; LUSC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.8 0.3 1.51e-8 Cognitive test performance; LUSC cis rs911555 0.692 rs7145753 chr14:103866100 G/A cg12935359 chr14:103987150 CKB 0.65 10.48 0.5 2.01e-22 Intelligence (multi-trait analysis); LUSC cis rs4654899 1.000 rs7521675 chr1:21424070 T/C cg01072550 chr1:21505969 NA -0.53 -8.09 -0.4 1.11e-14 Superior frontal gyrus grey matter volume; LUSC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg05776053 chr2:74358815 NA 0.45 7.13 0.36 6.06e-12 Gestational age at birth (maternal effect); LUSC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg05373962 chr22:49881684 NA -0.43 -10.23 -0.49 1.53e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7819412 0.936 rs7814499 chr8:11040647 A/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.02 -0.31 4.54e-9 Triglycerides; LUSC cis rs11785693 0.862 rs17351027 chr8:4987098 A/G cg26367366 chr8:4980734 NA -0.67 -8.07 -0.4 1.24e-14 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs4975709 1.000 rs2279588 chr5:1878021 G/A cg15595755 chr5:1867978 NA 0.4 6.28 0.32 1.06e-9 Cardiovascular disease risk factors; LUSC cis rs4786125 0.581 rs7194903 chr16:6918194 A/G cg03623568 chr16:6915990 A2BP1 -0.43 -7.5 -0.38 5.74e-13 Heart rate variability traits (SDNN); LUSC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg18876405 chr7:65276391 NA -0.55 -8.54 -0.42 4.92e-16 Aortic root size; LUSC trans rs10511400 0.618 rs923728 chr3:119918149 C/T cg02809009 chr19:50354510 PTOV1 0.65 6.3 0.33 9.19e-10 Economic and political preferences (feminism/equality); LUSC cis rs926392 0.932 rs6124105 chr20:37686081 G/A cg27552599 chr20:37590471 DHX35 0.33 5.75 0.3 2e-8 Dialysis-related mortality; LUSC cis rs7189233 0.531 rs9921627 chr16:53482692 G/A cg09728985 chr16:53543985 NA -0.3 -5.78 -0.3 1.73e-8 Intelligence (multi-trait analysis); LUSC cis rs796364 0.951 rs36086821 chr2:201067436 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.71 0.3 2.56e-8 Schizophrenia; LUSC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg24838063 chr12:130822603 PIWIL1 0.7 10.79 0.51 1.7e-23 Menopause (age at onset); LUSC cis rs7824557 0.507 rs7010590 chr8:11062882 C/T cg21775007 chr8:11205619 TDH 0.54 8.0 0.4 2.08e-14 Retinal vascular caliber; LUSC trans rs8072100 0.782 rs28507314 chr17:45551402 C/T cg04995722 chr7:26192034 NFE2L3 -0.43 -6.67 -0.34 1.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg05072774 chr3:49840536 C3orf54 -0.42 -5.69 -0.3 2.71e-8 Resting heart rate; LUSC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg06453172 chr10:134556979 INPP5A -0.49 -6.18 -0.32 1.91e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg11062466 chr8:58055876 NA 0.68 8.12 0.41 8.95e-15 Developmental language disorder (linguistic errors); LUSC cis rs7100689 0.646 rs10749573 chr10:82136839 T/A cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg06108461 chr20:60628389 TAF4 -0.73 -11.64 -0.54 1.67e-26 Body mass index; LUSC trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg14343924 chr8:8086146 FLJ10661 -0.43 -6.1 -0.32 2.92e-9 Myopia (pathological); LUSC cis rs7246967 0.673 rs34342502 chr19:22881428 C/A cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs8030485 0.536 rs4778918 chr15:79434040 T/C cg17916960 chr15:79447300 NA 0.4 7.29 0.37 2.27e-12 Left ventricle wall thickness; LUSC cis rs243505 1.000 rs1019058 chr7:148424243 A/G cg09806900 chr7:148480153 CUL1 -0.48 -6.84 -0.35 3.81e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9325144 0.624 rs10783330 chr12:39114084 A/G cg13010199 chr12:38710504 ALG10B -0.49 -7.62 -0.39 2.56e-13 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -8.31 -0.41 2.37e-15 Alzheimer's disease; LUSC cis rs2282300 0.653 rs67745574 chr11:30234839 C/T cg25418670 chr11:30344373 C11orf46 -0.66 -9.48 -0.46 4.95e-19 Morning vs. evening chronotype; LUSC cis rs11098499 0.954 rs12507964 chr4:120413061 T/A cg24375607 chr4:120327624 NA 0.79 12.05 0.55 5.19e-28 Corneal astigmatism; LUSC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg22823121 chr1:150693482 HORMAD1 0.54 8.11 0.41 9.61e-15 Melanoma; LUSC cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.46e-10 Body mass index; LUSC cis rs5769765 0.542 rs1033666 chr22:50252783 T/C cg02269571 chr22:50332266 NA 0.58 7.48 0.38 6.75e-13 Schizophrenia; LUSC cis rs1577917 1.000 rs12209127 chr6:86724427 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.68e-17 Response to antipsychotic treatment; LUSC cis rs7572644 0.656 rs12463914 chr2:28057359 C/T cg27432699 chr2:27873401 GPN1 0.53 6.76 0.35 6.23e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg03929089 chr4:120376271 NA -1.04 -20.21 -0.74 7.12e-60 Height; LUSC cis rs6456156 0.565 rs2181058 chr6:167465330 A/T cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs3806843 0.576 rs405192 chr5:140324710 T/G cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg05340658 chr4:99064831 C4orf37 0.63 10.13 0.48 3.37e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6546550 0.935 rs13017134 chr2:70090579 C/G cg02498382 chr2:70120550 SNRNP27 -0.29 -7.17 -0.37 4.97e-12 Prevalent atrial fibrillation; LUSC cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg12365402 chr11:9010492 NRIP3 -0.49 -9.43 -0.46 7.35e-19 Hemoglobin concentration; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg11408517 chr6:150039536 LATS1 0.41 6.02 0.31 4.62e-9 Triglycerides; LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.51 0.53 4.85e-26 Menopause (age at onset); LUSC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg21535942 chr1:75199100 CRYZ;TYW3 -0.5 -7.25 -0.37 2.91e-12 Resistin levels; LUSC cis rs9815354 0.812 rs73071344 chr3:41827062 C/T cg03022575 chr3:42003672 ULK4 0.83 8.43 0.42 1.06e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs68170813 0.559 rs12535081 chr7:106979291 C/T cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.69 -0.3 2.76e-8 Coronary artery disease; LUSC cis rs4595586 0.525 rs11611705 chr12:39426828 C/T cg13010199 chr12:38710504 ALG10B 0.45 6.38 0.33 5.89e-10 Morning vs. evening chronotype; LUSC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg20891283 chr12:69753455 YEATS4 -0.65 -11.08 -0.52 1.63e-24 Blood protein levels; LUSC cis rs3540 0.553 rs4031431 chr15:90990782 G/T cg04176472 chr15:90893244 GABARAPL3 0.34 5.86 0.31 1.08e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg24531977 chr5:56204891 C5orf35 -1.01 -14.28 -0.62 1.86e-36 Initial pursuit acceleration; LUSC cis rs6484504 0.512 rs7940020 chr11:31366453 T/G cg26647111 chr11:31128758 NA 0.4 5.65 0.3 3.36e-8 Red blood cell count; LUSC cis rs3749237 0.964 rs1799845 chr3:49847623 A/G cg05072774 chr3:49840536 C3orf54 -0.43 -5.91 -0.31 8.3e-9 Resting heart rate; LUSC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.9 0.78 1.85e-70 Height; LUSC cis rs4363385 0.668 rs1933386 chr1:152959265 T/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.43 -0.38 9.41e-13 Inflammatory skin disease; LUSC cis rs6496667 0.533 rs7173201 chr15:90991195 A/T cg22089800 chr15:90895588 ZNF774 0.53 7.56 0.38 3.96e-13 Rheumatoid arthritis; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.1 -0.32 2.89e-9 Bipolar disorder and schizophrenia; LUSC trans rs1941687 0.669 rs7243220 chr18:31408110 T/G cg27147174 chr7:100797783 AP1S1 -0.44 -6.58 -0.34 1.87e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.3 -0.41 2.65e-15 Lung cancer; LUSC trans rs9467711 0.606 rs9379899 chr6:26603015 T/A cg06606381 chr12:133084897 FBRSL1 -0.68 -6.74 -0.35 7.03e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg10660136 chr2:232379107 C2orf52 0.46 6.05 0.31 3.81e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg10360139 chr7:1886902 MAD1L1 -0.47 -7.26 -0.37 2.67e-12 Bipolar disorder and schizophrenia; LUSC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg23985595 chr17:80112537 CCDC57 -0.3 -5.71 -0.3 2.55e-8 Life satisfaction; LUSC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg21770322 chr7:97807741 LMTK2 0.41 7.21 0.37 3.79e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs12310956 0.532 rs10844712 chr12:33961022 G/A cg13010199 chr12:38710504 ALG10B 0.53 7.86 0.4 5.47e-14 Morning vs. evening chronotype; LUSC cis rs12541635 0.639 rs10095827 chr8:106984403 A/G cg10147462 chr8:107024639 NA 0.66 13.52 0.59 1.56e-33 Age of smoking initiation; LUSC cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg07424592 chr7:64974309 NA 0.7 6.15 0.32 2.24e-9 Diabetic kidney disease; LUSC cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg04455712 chr21:45112962 RRP1B 0.45 8.45 0.42 8.82e-16 Mean corpuscular volume; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg05025164 chr4:1340916 KIAA1530 0.42 6.34 0.33 7.29e-10 Obesity-related traits; LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg18402987 chr7:1209562 NA 0.7 7.58 0.38 3.42e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7589728 0.748 rs35051888 chr2:88482258 G/A cg04511125 chr2:88470314 THNSL2 0.72 6.83 0.35 3.94e-11 Plasma clusterin levels; LUSC cis rs6847149 0.929 rs6839680 chr4:110765496 A/G cg07850274 chr4:110748770 RRH -0.52 -8.16 -0.41 6.87e-15 Exercise treadmill test traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22831313 chr6:125623058 HDDC2 -0.42 -6.37 -0.33 6.35e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg11751927 chr11:117857137 IL10RA 0.45 6.15 0.32 2.27e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg15790184 chr11:494944 RNH1 0.49 7.53 0.38 4.71e-13 Systemic lupus erythematosus; LUSC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg00339695 chr16:24857497 SLC5A11 0.59 8.78 0.43 8.37e-17 Intelligence (multi-trait analysis); LUSC cis rs6845621 0.901 rs11725069 chr4:18929324 G/T cg12196642 chr4:18937545 NA -0.36 -6.72 -0.34 8.04e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs60695258 0.517 rs867196 chr4:87971600 G/C cg10685359 chr4:87814065 C4orf36 -0.35 -6.24 -0.32 1.3e-9 Hematocrit; LUSC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.29 -0.45 1.98e-18 Monocyte percentage of white cells; LUSC cis rs8078723 1.000 rs7214085 chr17:38169095 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.93 -0.35 2.15e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg08048268 chr3:133502702 NA -0.4 -7.33 -0.37 1.71e-12 Iron status biomarkers; LUSC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg10523679 chr1:76189770 ACADM -0.83 -11.48 -0.53 6.28e-26 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9653442 0.712 rs6714788 chr2:100686173 A/G cg07810366 chr2:100720526 AFF3 0.45 7.6 0.38 2.95e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg03146154 chr1:46216737 IPP 0.52 7.67 0.39 1.95e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC cis rs6456156 0.742 rs2022000 chr6:167529611 A/G cg07741184 chr6:167504864 NA -0.36 -6.34 -0.33 7.42e-10 Primary biliary cholangitis; LUSC cis rs4285028 0.898 rs12491991 chr3:121706021 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.69 9.4 0.46 9.18e-19 Multiple sclerosis; LUSC cis rs11671005 0.735 rs45617039 chr19:58951096 G/A cg13877915 chr19:58951672 ZNF132 0.44 5.68 0.3 2.96e-8 Mean platelet volume; LUSC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg22535103 chr8:58192502 C8orf71 -0.74 -7.58 -0.38 3.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg24692254 chr21:30365293 RNF160 -0.8 -14.27 -0.62 2.07e-36 Dental caries; LUSC cis rs7809950 1.000 rs17154104 chr7:107090698 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.81 -0.43 7.01e-17 Coronary artery disease; LUSC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.77 0.3 1.8e-8 Life satisfaction; LUSC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg06636001 chr8:8085503 FLJ10661 0.59 9.24 0.45 2.92e-18 Mood instability; LUSC cis rs7599312 0.963 rs10184221 chr2:213409014 G/A cg16329650 chr2:213403929 ERBB4 0.66 9.19 0.45 4.21e-18 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs1814175 0.511 rs61905634 chr11:49819736 G/A cg03929089 chr4:120376271 NA -1.03 -19.86 -0.74 1.61e-58 Height; LUSC cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg06784218 chr1:46089804 CCDC17 -0.57 -11.25 -0.52 4.27e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9400467 0.508 rs456871 chr6:111687650 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.03 -0.36 1.14e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg23625390 chr15:77176239 SCAPER 0.39 5.65 0.3 3.36e-8 Blood metabolite levels; LUSC cis rs8025790 0.508 rs35930676 chr15:67827705 G/A cg05925327 chr15:68127851 NA -0.39 -5.98 -0.31 5.69e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg11645453 chr3:52864694 ITIH4 -0.4 -10.04 -0.48 6.91e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs62238980 0.614 rs80321137 chr22:32460767 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs4974559 0.947 rs10000797 chr4:1345647 G/A cg02980000 chr4:1222292 CTBP1 0.73 7.22 0.37 3.59e-12 Systolic blood pressure; LUSC cis rs6690583 0.623 rs12042018 chr1:85436937 T/C cg22153463 chr1:85462885 MCOLN2 0.61 5.87 0.31 1.07e-8 Serum sulfate level; LUSC cis rs10089 0.953 rs2016015 chr5:127527253 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.68 0.54 1.12e-26 Ileal carcinoids; LUSC cis rs9790314 0.905 rs7633186 chr3:161003124 A/G cg03342759 chr3:160939853 NMD3 -0.52 -8.77 -0.43 9.03e-17 Morning vs. evening chronotype; LUSC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg25124228 chr12:125621409 AACS -0.47 -7.14 -0.36 5.84e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs600231 0.665 rs2105608 chr11:65228618 T/A cg21890820 chr11:65308645 LTBP3 0.5 7.33 0.37 1.77e-12 Bone mineral density; LUSC cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg01579765 chr21:45077557 HSF2BP -0.49 -10.41 -0.49 3.67e-22 Mean corpuscular volume; LUSC cis rs6469656 0.881 rs35338453 chr8:117791493 C/T cg24004040 chr8:117650383 NA 0.41 5.79 0.3 1.63e-8 Colorectal cancer; LUSC cis rs524023 0.756 rs475688 chr11:64364291 C/T cg19131476 chr11:64387923 NRXN2 0.36 8.26 0.41 3.57e-15 Urate levels in obese individuals; LUSC cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 -0.52 -6.91 -0.35 2.53e-11 Multiple sclerosis; LUSC cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.4 -0.38 1.11e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1322512 0.713 rs75583601 chr6:152929264 C/T cg27316956 chr6:152958899 SYNE1 -0.35 -5.87 -0.31 1.04e-8 Tonometry; LUSC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.4 -5.81 -0.3 1.44e-8 Tonsillectomy; LUSC cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg02423579 chr7:2872169 GNA12 -0.37 -5.68 -0.3 2.96e-8 Height; LUSC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg11062466 chr8:58055876 NA 0.67 8.5 0.42 6.28e-16 Developmental language disorder (linguistic errors); LUSC cis rs11971779 0.941 rs74299967 chr7:139043769 G/T cg07862535 chr7:139043722 LUC7L2 0.74 8.31 0.41 2.47e-15 Diisocyanate-induced asthma; LUSC cis rs4604732 0.642 rs7515859 chr1:247640057 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.36 5.82 0.3 1.38e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs7395662 0.591 rs10838968 chr11:48595046 A/G cg15704280 chr7:45808275 SEPT13 -0.46 -6.36 -0.33 6.56e-10 HDL cholesterol; LUSC cis rs7617773 0.817 rs9830016 chr3:48282494 A/G cg20734569 chr3:48348370 SPINK8 -0.41 -7.37 -0.37 1.37e-12 Coronary artery disease; LUSC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg05754148 chr16:3507555 NAT15 0.53 7.99 0.4 2.2e-14 Tuberculosis; LUSC cis rs6901250 0.655 rs9384990 chr6:117126941 A/G cg12892004 chr6:117198278 RFX6 0.4 7.59 0.38 3.22e-13 C-reactive protein levels; LUSC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg16680214 chr1:154839983 KCNN3 -0.55 -10.74 -0.51 2.65e-23 Prostate cancer; LUSC trans rs3857536 0.776 rs7765531 chr6:66932886 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg12311346 chr5:56204834 C5orf35 -0.66 -10.18 -0.49 2.25e-21 Coronary artery disease; LUSC cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg05347473 chr6:146136440 FBXO30 0.57 9.83 0.47 3.39e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9814567 1.000 rs9841212 chr3:134191938 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.16 -0.55 2.05e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10876993 0.928 rs813854 chr12:58071347 A/G cg15848620 chr12:58087721 OS9 -0.57 -8.24 -0.41 4.01e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs3820928 0.709 rs10178202 chr2:227914561 C/T cg11843606 chr2:227700838 RHBDD1 -0.5 -6.67 -0.34 1.07e-10 Pulmonary function; LUSC cis rs2262909 0.962 rs2017521 chr19:22126138 T/C cg11619707 chr19:22235551 ZNF257 -0.39 -5.72 -0.3 2.32e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC trans rs61931739 0.658 rs708142 chr12:33719872 G/A cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg11941060 chr3:133502564 NA -0.52 -8.0 -0.4 2.11e-14 Iron status biomarkers; LUSC cis rs7937682 0.924 rs12791699 chr11:111505880 T/C cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC trans rs62103177 0.810 rs62103192 chr18:77629050 A/T cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs1577917 0.681 rs4707211 chr6:86232710 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.35 5.65 0.3 3.38e-8 Response to antipsychotic treatment; LUSC trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.68 -0.39 1.83e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.49 -7.45 -0.38 7.91e-13 Alzheimer's disease (late onset); LUSC cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg23992470 chr4:843637 GAK -0.54 -6.2 -0.32 1.62e-9 Intelligence (multi-trait analysis); LUSC cis rs7712401 0.601 rs417268 chr5:122345012 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.25 -0.45 2.68e-18 Mean platelet volume; LUSC cis rs12310956 0.532 rs1589903 chr12:33943019 C/T cg06521331 chr12:34319734 NA -0.45 -7.29 -0.37 2.33e-12 Morning vs. evening chronotype; LUSC cis rs10979 0.557 rs9403517 chr6:143909400 T/C cg25407410 chr6:143891975 LOC285740 -0.65 -8.16 -0.41 6.7e-15 Hypospadias; LUSC cis rs17270561 0.636 rs7775354 chr6:25745266 T/A cg17691542 chr6:26056736 HIST1H1C 0.55 7.79 0.39 8.71e-14 Iron status biomarkers; LUSC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg23758822 chr17:41437982 NA 0.99 18.41 0.71 9.28e-53 Menopause (age at onset); LUSC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.23e-12 Extrinsic epigenetic age acceleration; LUSC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg01570182 chr17:44337453 NA 0.93 14.09 0.61 1.05e-35 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg00012203 chr2:219082015 ARPC2 -0.79 -13.56 -0.6 1.08e-33 Colorectal cancer; LUSC cis rs9527 0.590 rs10509764 chr10:104776475 G/A cg04362960 chr10:104952993 NT5C2 0.62 9.83 0.47 3.35e-20 Arsenic metabolism; LUSC trans rs1934953 0.556 rs4917678 chr10:96851966 A/G cg08498836 chr3:149292366 WWTR1 0.35 6.0 0.31 5.13e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs6598955 0.671 rs12139514 chr1:26575939 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7707921 0.767 rs226196 chr5:81576965 C/A cg15871215 chr5:81402204 ATG10 0.43 6.72 0.35 7.83e-11 Breast cancer; LUSC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.82 0.39 7e-14 Parkinson's disease; LUSC cis rs9650315 0.929 rs67565274 chr8:57165771 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.07 0.36 9.07e-12 Height; LUSC cis rs6541297 0.775 rs4846910 chr1:230291441 C/A cg20703242 chr1:230279135 GALNT2 0.63 8.71 0.43 1.47e-16 Coronary artery disease; LUSC cis rs9814567 0.712 rs9838467 chr3:134332222 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.62 -0.57 4.01e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.47 0.75 6.15e-61 Homoarginine levels; LUSC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg14883916 chr11:6947541 ZNF215 0.46 6.05 0.31 3.92e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg22963979 chr7:1858916 MAD1L1 -0.52 -7.66 -0.39 2.06e-13 Schizophrenia; LUSC trans rs12310956 0.532 rs11052933 chr12:33969881 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.42 0.42 1.12e-15 Morning vs. evening chronotype; LUSC trans rs35110281 0.693 rs2251253 chr21:45092257 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.61 10.36 0.49 5.35e-22 Mean corpuscular volume; LUSC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg05835009 chr4:710272 PCGF3 0.57 8.73 0.43 1.25e-16 White blood cell count; LUSC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.56e-24 Aortic root size; LUSC cis rs950169 0.881 rs62029596 chr15:84955434 A/G cg17507749 chr15:85114479 UBE2QP1 0.65 8.15 0.41 7.64e-15 Schizophrenia; LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg16606324 chr3:10149918 C3orf24 0.59 8.55 0.42 4.49e-16 Alzheimer's disease; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg07792738 chr5:148738024 PCYOX1L 0.36 5.98 0.31 5.66e-9 Schizophrenia; LUSC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg05425664 chr17:57184151 TRIM37 -0.55 -8.25 -0.41 3.79e-15 Intelligence (multi-trait analysis); LUSC cis rs11030122 0.702 rs11030276 chr11:3946134 A/G cg18678763 chr11:4115507 RRM1 -0.45 -5.77 -0.3 1.79e-8 Mean platelet volume;Platelet distribution width; LUSC trans rs4650994 0.525 rs4457535 chr1:178497186 C/T cg05059571 chr16:84539110 KIAA1609 0.47 9.22 0.45 3.56e-18 HDL cholesterol levels;HDL cholesterol; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg20793623 chr3:41236272 NA -0.35 -6.24 -0.32 1.35e-9 Schizophrenia; LUSC cis rs4660306 1.000 rs10157597 chr1:45990278 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.53 -0.34 2.48e-10 Homocysteine levels; LUSC trans rs4332037 0.826 rs4721188 chr7:1953615 G/A cg25206134 chr2:45395956 NA -0.51 -6.08 -0.32 3.34e-9 Bipolar disorder; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.92 0.77 1.24e-66 Prudent dietary pattern; LUSC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg10117171 chr1:25599238 RHD 0.38 5.85 0.31 1.15e-8 Erythrocyte sedimentation rate; LUSC cis rs5769707 0.967 rs9616713 chr22:50049109 G/A cg05373962 chr22:49881684 NA -0.44 -10.7 -0.51 3.68e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg06484146 chr7:12443880 VWDE -0.62 -6.24 -0.32 1.36e-9 Coronary artery disease; LUSC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg24250549 chr1:154909240 PMVK 0.57 9.15 0.45 5.78e-18 Prostate cancer; LUSC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg20891558 chr2:74357851 NA 0.83 15.43 0.65 6.13e-41 Gestational age at birth (maternal effect); LUSC cis rs4727027 0.704 rs2888600 chr7:148908562 C/T cg23158103 chr7:148848205 ZNF398 -0.45 -7.25 -0.37 2.86e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg11812906 chr14:75593930 NEK9 -0.64 -10.75 -0.51 2.31e-23 Height; LUSC trans rs2018683 0.707 rs917216 chr7:28971472 A/G cg19402173 chr7:128379420 CALU -0.46 -7.07 -0.36 9.25e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs11190604 0.943 rs2495744 chr10:102329409 C/T cg16342193 chr10:102329863 NA -0.36 -6.66 -0.34 1.15e-10 Palmitoleic acid (16:1n-7) levels; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg08125401 chr15:74726457 SEMA7A 0.5 6.02 0.31 4.63e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs909341 0.629 rs3761124 chr20:62288752 T/C cg16989086 chr20:62203971 PRIC285 -0.53 -7.36 -0.37 1.41e-12 Atopic dermatitis; LUSC trans rs7726839 0.574 rs12517345 chr5:628294 G/A cg25482853 chr8:67687455 SGK3 1.11 15.42 0.64 6.91e-41 Obesity-related traits; LUSC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg00310523 chr12:86230176 RASSF9 -0.43 -7.91 -0.4 3.85e-14 Major depressive disorder; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg13400516 chr1:2159040 SKI 0.37 6.29 0.33 9.71e-10 Metabolite levels (Pyroglutamine); LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7568458 0.684 rs7593969 chr2:85809670 A/G cg02493740 chr2:85810744 VAMP5 0.52 9.12 0.45 6.97e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg27170947 chr2:26402098 FAM59B -0.65 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC cis rs8060686 0.641 rs8060893 chr16:68191608 A/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg08677398 chr8:58056175 NA 0.55 6.95 0.36 1.94e-11 Developmental language disorder (linguistic errors); LUSC cis rs877282 0.947 rs12358875 chr10:757531 T/C cg17470449 chr10:769945 NA 0.52 6.97 0.36 1.72e-11 Uric acid levels; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg06475894 chr1:223567955 C1orf65 -0.38 -5.99 -0.31 5.28e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg06637938 chr14:75390232 RPS6KL1 0.52 8.37 0.42 1.6e-15 Height; LUSC cis rs7937682 0.855 rs7109592 chr11:111533105 C/A cg09085632 chr11:111637200 PPP2R1B -1.11 -18.39 -0.71 1.14e-52 Primary sclerosing cholangitis; LUSC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg11812906 chr14:75593930 NEK9 -0.66 -11.23 -0.52 4.98e-25 Height; LUSC cis rs17125944 0.686 rs7143400 chr14:53324891 A/C cg00686598 chr14:53173677 PSMC6 -0.65 -5.82 -0.3 1.4e-8 Alzheimer's disease (late onset); LUSC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.14e-9 Menopause (age at onset); LUSC cis rs67311347 0.713 rs73073505 chr3:40310693 C/T cg02782426 chr3:40428986 ENTPD3 0.37 7.0 0.36 1.43e-11 Renal cell carcinoma; LUSC cis rs10740039 0.768 rs10821801 chr10:62371775 C/A cg18175470 chr10:62150864 ANK3 -0.44 -6.6 -0.34 1.66e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02018176 chr4:1364513 KIAA1530 0.71 12.82 0.57 7.19e-31 Longevity; LUSC cis rs16912285 0.688 rs7128427 chr11:24338598 C/T ch.11.24196551F chr11:24239977 NA 0.85 8.18 0.41 6.17e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg11871910 chr12:69753446 YEATS4 0.71 11.97 0.55 1.05e-27 Blood protein levels; LUSC cis rs7572644 0.699 rs13400398 chr2:28162109 C/T cg27432699 chr2:27873401 GPN1 -0.51 -6.86 -0.35 3.39e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7089973 0.624 rs1359080 chr10:116582419 C/A cg23260525 chr10:116636907 FAM160B1 0.43 9.12 0.45 6.99e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg07936489 chr17:37558343 FBXL20 -0.72 -10.11 -0.48 3.96e-21 Glomerular filtration rate (creatinine); LUSC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg07936489 chr17:37558343 FBXL20 -0.7 -9.74 -0.47 6.83e-20 Glomerular filtration rate (creatinine); LUSC cis rs934734 0.563 rs11126035 chr2:65597066 T/C cg08085232 chr2:65598271 SPRED2 -0.43 -6.76 -0.35 6.04e-11 Rheumatoid arthritis; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg17949255 chr17:48942907 TOB1 0.41 6.24 0.32 1.34e-9 Mosquito bite size; LUSC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.19 -0.37 4.4e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg22862634 chr11:62369728 EML3;MTA2 0.59 9.23 0.45 3.24e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.41 -0.33 5.06e-10 Neuroticism; LUSC cis rs250677 0.522 rs6872172 chr5:148359529 G/C cg18129178 chr5:148520854 ABLIM3 0.52 7.36 0.37 1.41e-12 Breast cancer; LUSC cis rs1048238 0.506 rs698889 chr1:16267040 A/C cg21385522 chr1:16154831 NA -0.55 -8.26 -0.41 3.55e-15 Systolic blood pressure; LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -8.57 -0.42 3.87e-16 Bipolar disorder and schizophrenia; LUSC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg20607287 chr7:12443886 VWDE -0.58 -5.97 -0.31 6.11e-9 Coronary artery disease; LUSC cis rs17824933 0.836 rs2074233 chr11:60785464 G/A cg16817237 chr11:60793675 NA 0.36 5.74 0.3 2.15e-8 Multiple sclerosis; LUSC cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg11102782 chr19:18549136 ISYNA1 -0.35 -6.86 -0.35 3.29e-11 Breast cancer; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.99 14.11 0.61 8.99e-36 Platelet count; LUSC cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg12935359 chr14:103987150 CKB 0.65 10.68 0.5 4.17e-23 Intelligence (multi-trait analysis); LUSC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg24110177 chr3:50126178 RBM5 0.61 10.29 0.49 9.34e-22 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg18681998 chr4:17616180 MED28 -0.88 -15.36 -0.64 1.19e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs61931739 0.517 rs4931748 chr12:34140827 C/T cg26384229 chr12:38710491 ALG10B 0.72 11.4 0.53 1.24e-25 Morning vs. evening chronotype; LUSC cis rs72781680 0.752 rs55806536 chr2:23912697 A/G cg08917208 chr2:24149416 ATAD2B 1.0 10.2 0.49 1.84e-21 Lymphocyte counts; LUSC cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg12011299 chr4:100065546 ADH4 0.61 9.74 0.47 6.61e-20 Alcohol dependence; LUSC trans rs4332037 0.539 rs62444881 chr7:2052318 C/T cg10840412 chr1:235813424 GNG4 0.57 7.39 0.37 1.17e-12 Bipolar disorder; LUSC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg02931644 chr1:25747376 RHCE 0.34 6.19 0.32 1.81e-9 Plateletcrit;Mean corpuscular volume; LUSC cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg24558204 chr6:135376177 HBS1L 0.67 10.28 0.49 1.04e-21 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC trans rs12188164 1.000 rs34847072 chr5:437862 G/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 6.04 0.31 4.19e-9 Cystic fibrosis severity; LUSC cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -7.44 -0.38 8.74e-13 Body mass index (adult); LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg05368731 chr17:41323189 NBR1 0.92 16.06 0.66 2.14e-43 Menopause (age at onset); LUSC cis rs72772090 0.539 rs11738115 chr5:96113072 A/T cg17330273 chr5:96107758 CAST;ERAP1 0.66 7.36 0.37 1.43e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg00071950 chr4:10020882 SLC2A9 -0.52 -8.49 -0.42 6.87e-16 Bone mineral density; LUSC cis rs868036 0.718 rs16951275 chr15:68077168 T/C cg05925327 chr15:68127851 NA -0.43 -6.95 -0.36 1.91e-11 Restless legs syndrome; LUSC cis rs1538970 0.962 rs2153609 chr1:45814058 A/G cg05343316 chr1:45956843 TESK2 0.56 7.98 0.4 2.35e-14 Platelet count; LUSC cis rs807669 0.557 rs712958 chr22:19167409 T/C cg02655711 chr22:19163373 SLC25A1 0.7 12.27 0.56 8.16e-29 Metabolite levels; LUSC cis rs826838 0.904 rs10876086 chr12:39188208 C/A cg13010199 chr12:38710504 ALG10B 0.69 11.81 0.54 3.94e-27 Heart rate; LUSC trans rs61931739 0.534 rs1211286 chr12:34135581 T/C cg26384229 chr12:38710491 ALG10B 0.68 10.62 0.5 7e-23 Morning vs. evening chronotype; LUSC cis rs71403859 0.504 rs35203704 chr16:71959661 G/A cg03805757 chr16:71968109 PKD1L3 -0.6 -6.37 -0.33 6.29e-10 Post bronchodilator FEV1; LUSC cis rs8099014 0.906 rs4940692 chr18:56099715 A/G cg12907477 chr18:56117327 MIR122 0.45 6.84 0.35 3.83e-11 Platelet count; LUSC cis rs28785552 0.800 rs1971063 chr19:53232854 G/C cg22067481 chr19:53234126 ZNF611 -0.5 -6.68 -0.34 9.76e-11 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg11812906 chr14:75593930 NEK9 0.65 11.2 0.52 6.3e-25 Height; LUSC cis rs3782089 0.744 rs11545200 chr11:65319751 G/A cg00206168 chr11:65308501 LTBP3 1.33 8.86 0.44 4.93e-17 Height; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16322655 chr11:31391333 DNAJC24;DCDC1 0.37 6.23 0.32 1.41e-9 Asthma; LUSC trans rs11722228 0.522 rs12504600 chr4:10067138 C/A cg26043149 chr18:55253948 FECH 0.93 14.04 0.61 1.58e-35 Gout;Urate levels;Serum uric acid levels; LUSC cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg04455712 chr21:45112962 RRP1B -0.46 -8.9 -0.44 3.61e-17 Mean corpuscular volume; LUSC cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg08330031 chr10:104623503 C10orf32 0.31 5.66 0.3 3.32e-8 Arsenic metabolism; LUSC cis rs790123 0.541 rs12330293 chr3:122383035 G/A cg00926285 chr3:122398533 PARP14 -0.47 -5.98 -0.31 5.79e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs7617480 0.648 rs6806356 chr3:48727636 G/A cg21141812 chr3:48556323 PFKFB4 0.34 6.07 0.32 3.53e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg08213375 chr14:104286397 PPP1R13B 0.44 7.58 0.38 3.4e-13 Reticulocyte count; LUSC cis rs2970818 0.731 rs10849089 chr12:4661387 A/T cg11146114 chr12:4671731 NA -0.59 -6.14 -0.32 2.32e-9 Phosphorus levels; LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.69 -0.57 2.24e-30 Platelet count; LUSC cis rs9300255 0.602 rs10846486 chr12:123709927 G/A cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs926938 0.527 rs360584 chr1:115463181 G/A cg01522456 chr1:115632236 TSPAN2 -0.41 -6.44 -0.33 4.23e-10 Autism; LUSC cis rs7819412 0.539 rs11250131 chr8:11251175 C/T cg21775007 chr8:11205619 TDH -0.63 -9.61 -0.47 1.85e-19 Triglycerides; LUSC cis rs6740322 0.748 rs6720087 chr2:43468745 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.48 6.48 0.33 3.23e-10 Coronary artery disease; LUSC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg01652190 chr22:50026171 C22orf34 -0.3 -6.12 -0.32 2.64e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg16586182 chr3:47516702 SCAP -0.51 -8.01 -0.4 1.91e-14 Colorectal cancer; LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg23758822 chr17:41437982 NA 1.04 20.11 0.74 1.65e-59 Menopause (age at onset); LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.5 -8.41 -0.42 1.25e-15 Lymphocyte counts; LUSC trans rs800082 1.000 rs800084 chr3:144340494 C/T cg24215973 chr2:240111563 HDAC4 0.46 6.89 0.35 2.87e-11 Smoking behavior; LUSC cis rs1801251 1.000 rs11676216 chr2:233706368 C/T cg08000102 chr2:233561755 GIGYF2 -0.7 -11.58 -0.54 2.72e-26 Coronary artery disease; LUSC cis rs7903847 0.602 rs7916665 chr10:99157573 T/G cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs12530845 0.673 rs4269479 chr7:135332379 C/T cg23117316 chr7:135346802 PL-5283 -0.62 -9.56 -0.46 2.64e-19 Red blood cell traits; LUSC cis rs7100689 0.646 rs2050824 chr10:82123563 G/A cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.2 0.37 3.98e-12 Bipolar disorder; LUSC cis rs1559088 0.895 rs1974784 chr19:33551563 T/G cg17764715 chr19:33622953 WDR88 0.58 7.9 0.4 4.17e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7980687 0.550 rs1727324 chr12:123698603 A/T cg00376283 chr12:123451042 ABCB9 0.7 7.93 0.4 3.22e-14 Height;Educational attainment;Head circumference (infant); LUSC trans rs4942242 0.663 rs9525815 chr13:44223692 T/C cg19169023 chr15:41853346 TYRO3 -0.57 -8.71 -0.43 1.48e-16 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2204008 0.538 rs61931093 chr12:38242911 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.49 -0.42 6.98e-16 Bladder cancer; LUSC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg15704280 chr7:45808275 SEPT13 -0.53 -7.34 -0.37 1.63e-12 HDL cholesterol; LUSC cis rs2762353 0.935 rs1165195 chr6:25815080 T/G cg15691649 chr6:25882328 NA -0.36 -5.75 -0.3 1.96e-8 Blood metabolite levels; LUSC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.06 15.23 0.64 3.66e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg02376097 chr19:46275166 DMPK 0.4 6.99 0.36 1.52e-11 Coronary artery disease; LUSC trans rs11088226 0.581 rs2833862 chr21:33884390 A/G cg09050820 chr6:167586206 TCP10L2 0.45 6.96 0.36 1.82e-11 Gastritis; LUSC cis rs11614062 0.761 rs11107115 chr12:93972987 A/G cg18151635 chr12:93972918 NA -0.63 -8.68 -0.43 1.73e-16 Height; LUSC cis rs2979489 0.945 rs13250272 chr8:30294942 A/G cg26383811 chr8:30366931 RBPMS 0.48 7.33 0.37 1.75e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs1152591 0.792 rs1152595 chr14:64674981 T/C cg21174375 chr14:64681225 SYNE2 0.33 6.12 0.32 2.66e-9 Atrial fibrillation; LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10754283 0.967 rs10922680 chr1:90101326 C/T cg21401794 chr1:90099060 LRRC8C -0.64 -9.7 -0.47 9.36e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9914988 0.887 rs2070265 chr17:27075423 A/G cg09479241 chr17:27052676 TLCD1 -0.43 -6.04 -0.31 4.18e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7246967 0.551 rs6511367 chr19:22821270 G/A cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs34172651 0.917 rs11074654 chr16:24813743 A/G cg00339695 chr16:24857497 SLC5A11 0.37 6.49 0.33 3.1e-10 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01457413 chr19:9879603 ZNF846 0.49 7.54 0.38 4.37e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7647973 0.626 rs1491985 chr3:49739507 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -6.79 -0.35 5.19e-11 Menarche (age at onset); LUSC cis rs9403521 1.000 rs6915784 chr6:143984268 A/C cg18240653 chr6:144019428 PHACTR2 -0.46 -5.73 -0.3 2.24e-8 Obesity-related traits; LUSC cis rs8017423 0.935 rs7144070 chr14:90753047 T/C cg04374321 chr14:90722782 PSMC1 0.69 10.65 0.5 5.28e-23 Mortality in heart failure; LUSC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg21984481 chr17:79567631 NPLOC4 -0.68 -14.09 -0.61 1.06e-35 Eye color traits; LUSC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg00343986 chr7:65444356 GUSB 0.43 6.55 0.34 2.22e-10 Aortic root size; LUSC trans rs6076960 0.684 rs3852947 chr20:6255341 A/G cg17788362 chr6:86352627 SYNCRIP 0.47 6.99 0.36 1.54e-11 Smooth-surface caries; LUSC cis rs10512488 1.000 rs10512488 chr17:40963904 C/T cg05878104 chr17:40932452 WNK4 0.41 5.89 0.31 9.34e-9 Type 2 diabetes (age of onset); LUSC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Vitiligo; LUSC trans rs7824557 0.767 rs6991606 chr8:11176159 G/A cg15556689 chr8:8085844 FLJ10661 0.55 8.51 0.42 5.94e-16 Retinal vascular caliber; LUSC cis rs7712401 0.562 rs246267 chr5:122256104 A/T cg19077854 chr5:122220652 SNX24 0.42 9.68 0.47 1.04e-19 Mean platelet volume; LUSC cis rs4268898 0.610 rs72791170 chr2:24449776 C/T cg06627628 chr2:24431161 ITSN2 -0.86 -12.5 -0.56 1.08e-29 Asthma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03361557 chr19:19774500 ATP13A1 -0.52 -6.79 -0.35 5.05e-11 Bipolar disorder and schizophrenia; LUSC cis rs4595586 0.545 rs1588970 chr12:39403122 C/A cg13010199 chr12:38710504 ALG10B 0.42 6.1 0.32 2.87e-9 Morning vs. evening chronotype; LUSC cis rs1847202 0.592 rs13073005 chr3:72951007 C/T cg25664220 chr3:72788482 NA -0.42 -7.62 -0.38 2.6e-13 Motion sickness; LUSC cis rs6459804 0.967 rs4289696 chr7:157508399 C/T cg05731713 chr7:157510257 PTPRN2 0.49 9.33 0.45 1.55e-18 Bipolar disorder and schizophrenia; LUSC cis rs9479482 1.000 rs11754987 chr6:150351204 G/A cg25797454 chr6:150327115 RAET1K 0.34 7.8 0.39 7.9e-14 Alopecia areata; LUSC cis rs7267979 0.816 rs1044573 chr20:25206654 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.61 11.53 0.53 4.2e-26 Liver enzyme levels (alkaline phosphatase); LUSC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg03732007 chr1:2071316 PRKCZ 0.57 10.53 0.5 1.41e-22 Height; LUSC cis rs73206853 0.620 rs111354540 chr12:111150302 A/G cg12870014 chr12:110450643 ANKRD13A 0.64 6.25 0.32 1.23e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg23711669 chr6:146136114 FBXO30 0.9 16.67 0.67 8.1e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs3126085 0.935 rs4845750 chr1:152201217 A/G cg26876637 chr1:152193138 HRNR 0.49 6.32 0.33 8.36e-10 Atopic dermatitis; LUSC cis rs2274273 0.624 rs10141396 chr14:55816925 A/C cg04306507 chr14:55594613 LGALS3 0.47 9.15 0.45 5.85e-18 Protein biomarker; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26693529 chr2:20101779 TTC32 -0.4 -6.03 -0.31 4.36e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg02782426 chr3:40428986 ENTPD3 0.41 7.6 0.38 3.09e-13 Renal cell carcinoma; LUSC cis rs921968 0.678 rs689116 chr2:219433888 C/A cg02176678 chr2:219576539 TTLL4 0.61 11.03 0.52 2.41e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs17001868 0.568 rs73167007 chr22:40734241 G/C cg07138101 chr22:40742427 ADSL 0.64 7.62 0.38 2.72e-13 Mammographic density (dense area); LUSC cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg04756594 chr16:24857601 SLC5A11 0.34 5.73 0.3 2.27e-8 Intelligence (multi-trait analysis); LUSC cis rs701145 0.938 rs2596630 chr3:153992586 A/G cg17054900 chr3:154042577 DHX36 0.84 8.49 0.42 6.84e-16 Coronary artery disease; LUSC cis rs9303401 0.527 rs12939313 chr17:56755616 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 12.59 0.57 5.16e-30 Cognitive test performance; LUSC cis rs4950928 0.823 rs10920579 chr1:203158972 A/G cg17014757 chr1:203156097 CHI3L1 -0.43 -7.6 -0.38 2.92e-13 YKL-40 levels; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg05313129 chr8:58192883 C8orf71 -0.5 -5.71 -0.3 2.44e-8 Developmental language disorder (linguistic errors); LUSC cis rs9325144 0.647 rs17518186 chr12:38883665 T/C cg26384229 chr12:38710491 ALG10B -0.59 -9.08 -0.44 9.63e-18 Morning vs. evening chronotype; LUSC cis rs2219968 0.676 rs34077447 chr8:78839966 T/C cg00738934 chr8:78996279 NA -0.35 -5.94 -0.31 6.98e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22544720 chr18:61089873 VPS4B -0.44 -6.64 -0.34 1.3e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3741151 1.000 rs75007932 chr11:73080336 G/A cg17517138 chr11:73019481 ARHGEF17 1.11 9.05 0.44 1.23e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.94 -0.4 3.13e-14 Attention deficit hyperactivity disorder; LUSC cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg05347473 chr6:146136440 FBXO30 -0.65 -11.19 -0.52 6.83e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs1801251 1.000 rs12474040 chr2:233615345 T/G cg08000102 chr2:233561755 GIGYF2 0.68 11.29 0.53 2.97e-25 Coronary artery disease; LUSC cis rs11098499 0.566 rs17051356 chr4:120585308 C/T cg24375607 chr4:120327624 NA 0.73 10.41 0.49 3.68e-22 Corneal astigmatism; LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.8 -0.39 7.87e-14 Gut microbiome composition (summer); LUSC cis rs9527 0.569 rs10786730 chr10:104724200 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.4 0.46 9.06e-19 Arsenic metabolism; LUSC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg03264133 chr6:25882463 NA -0.47 -8.11 -0.41 9.79e-15 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg16624210 chr5:671434 TPPP -0.5 -6.56 -0.34 2.06e-10 Obesity-related traits; LUSC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.74 -9.38 -0.46 1.01e-18 Gut microbiome composition (summer); LUSC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC cis rs2227930 0.506 rs953135 chr3:142121826 C/T cg16271453 chr3:142027066 XRN1 -0.54 -9.69 -0.47 9.77e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs5769765 0.865 rs3788730 chr22:50244695 C/T cg26441486 chr22:50317300 CRELD2 -0.52 -7.94 -0.4 3.14e-14 Schizophrenia; LUSC cis rs4839827 1 rs4839827 chr6:96853967 C/T cg06623918 chr6:96969491 KIAA0776 0.56 8.99 0.44 1.85e-17 Migraine; LUSC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg00825309 chr19:58991885 ZNF446 -0.52 -7.72 -0.39 1.4e-13 Uric acid clearance; LUSC cis rs4077515 0.967 rs4266763 chr9:139289825 C/T cg14019695 chr9:139328340 INPP5E -0.47 -8.94 -0.44 2.75e-17 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9790314 1.000 rs336579 chr3:161086610 G/A cg04691961 chr3:161091175 C3orf57 -0.35 -6.09 -0.32 3.03e-9 Morning vs. evening chronotype; LUSC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg13902645 chr11:5959945 NA -0.6 -8.44 -0.42 9.71e-16 DNA methylation (variation); LUSC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.27 -0.32 1.1e-9 Extrinsic epigenetic age acceleration; LUSC trans rs7944735 0.517 rs12274550 chr11:48196752 C/A cg15704280 chr7:45808275 SEPT13 0.71 6.75 0.35 6.59e-11 Intraocular pressure; LUSC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.42 0.38 9.68e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs28830936 0.966 rs1918310 chr15:42065253 A/C cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.26 -0.32 1.17e-9 Diastolic blood pressure; LUSC cis rs77633900 0.614 rs113557153 chr15:76994445 A/G cg21673338 chr15:77095150 SCAPER -0.79 -6.87 -0.35 3.12e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg20684491 chr1:25596433 NA 0.39 6.26 0.32 1.15e-9 Erythrocyte sedimentation rate; LUSC cis rs782590 0.967 rs1823893 chr2:55788921 T/C cg18811423 chr2:55921094 PNPT1 0.83 14.33 0.62 1.2e-36 Metabolic syndrome; LUSC cis rs4588572 0.615 rs4143070 chr5:77769094 G/C cg11547950 chr5:77652471 NA -0.46 -6.91 -0.35 2.46e-11 Triglycerides; LUSC cis rs9372498 0.505 rs62424202 chr6:118851027 T/C cg18833306 chr6:118973337 C6orf204 -0.44 -5.68 -0.3 2.89e-8 Diastolic blood pressure; LUSC cis rs10791097 0.694 rs7940027 chr11:130745591 A/G cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs28595532 0.546 rs17516389 chr4:119239267 T/C cg21605333 chr4:119757512 SEC24D 0.77 6.5 0.34 2.93e-10 Cannabis dependence symptom count; LUSC cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg24450063 chr1:156163899 SLC25A44 1.07 17.26 0.69 3.57e-48 Testicular germ cell tumor; LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.21 0.37 3.79e-12 Alzheimer's disease; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.14 -0.58 4.64e-32 Platelet count; LUSC cis rs9467711 0.659 rs3734542 chr6:26468326 G/A cg09904177 chr6:26538194 HMGN4 -0.76 -6.02 -0.31 4.72e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2235649 0.833 rs55684627 chr16:1848817 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.04 -0.31 4.07e-9 Blood metabolite levels; LUSC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.5 0.38 5.88e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs10016947 1.000 rs10028984 chr4:104249970 T/C cg02356640 chr11:1501973 HCCA2 0.68 6.01 0.31 4.99e-9 Breast cancer; LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03576123 chr11:487126 PTDSS2 -1.03 -10.97 -0.51 4.09e-24 Body mass index; LUSC cis rs710865 0.627 rs10799710 chr1:19483209 A/G cg13387374 chr1:19411106 UBR4 0.53 8.34 0.42 1.92e-15 Brain structure; LUSC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg18512352 chr11:47633146 NA -0.47 -9.32 -0.45 1.58e-18 Subjective well-being; LUSC cis rs7208859 0.673 rs73265633 chr17:29236306 G/T cg13385521 chr17:29058706 SUZ12P 0.59 5.7 0.3 2.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs174601 0.615 rs174534 chr11:61549458 C/T cg19610905 chr11:61596333 FADS2 0.46 6.97 0.36 1.69e-11 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC cis rs2115630 1.000 rs2879828 chr15:85361977 G/T cg09876464 chr15:85330779 ZNF592 0.36 6.68 0.34 9.78e-11 P wave terminal force; LUSC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.39 0.56 3.01e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg11812906 chr14:75593930 NEK9 -0.64 -11.08 -0.52 1.66e-24 Height; LUSC cis rs240764 0.618 rs846778 chr6:101273147 T/C cg09795085 chr6:101329169 ASCC3 0.47 6.64 0.34 1.26e-10 Neuroticism; LUSC cis rs2970818 0.764 rs11063179 chr12:4580488 G/A cg11146114 chr12:4671731 NA -0.71 -6.77 -0.35 5.8e-11 Phosphorus levels; LUSC cis rs55665837 1.000 rs3923294 chr11:14441402 T/G cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs7587476 0.822 rs6726763 chr2:215681580 T/G cg04004882 chr2:215674386 BARD1 0.47 6.2 0.32 1.62e-9 Neuroblastoma; LUSC cis rs4237845 0.837 rs7971877 chr12:58287630 T/G cg00677455 chr12:58241039 CTDSP2 0.5 7.53 0.38 4.79e-13 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.835 rs723991 chr17:56482039 G/A cg12560992 chr17:57184187 TRIM37 -0.71 -12.61 -0.57 4.42e-30 Intelligence (multi-trait analysis); LUSC cis rs6690583 0.623 rs61768852 chr1:85454613 T/C cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.02e-10 Serum sulfate level; LUSC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.75 0.3 2.03e-8 Intelligence (multi-trait analysis); LUSC cis rs12618769 0.597 rs17505326 chr2:99156807 T/A cg10123293 chr2:99228465 UNC50 0.49 7.92 0.4 3.53e-14 Bipolar disorder; LUSC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg17294928 chr15:75287854 SCAMP5 -0.75 -10.03 -0.48 7.03e-21 Blood trace element (Zn levels); LUSC cis rs17095355 1.000 rs12244557 chr10:111746142 T/C cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.02 -0.4 1.8e-14 Biliary atresia; LUSC cis rs12579753 0.879 rs11115010 chr12:82165895 G/T cg21231944 chr12:82153410 PPFIA2 -0.38 -6.09 -0.32 3.07e-9 Resting heart rate; LUSC cis rs113835537 0.529 rs74869459 chr11:66296569 T/C cg24851651 chr11:66362959 CCS 0.55 8.06 0.4 1.33e-14 Airway imaging phenotypes; LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.45 7.76 0.39 1.05e-13 Electroencephalogram traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07396495 chr16:53468716 RBL2 -0.52 -6.5 -0.34 2.85e-10 Bipolar disorder and schizophrenia; LUSC cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg22590775 chr19:49891494 CCDC155 0.55 8.03 0.4 1.66e-14 Multiple sclerosis; LUSC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.602 rs941305 chr12:123715266 T/C cg05973401 chr12:123451056 ABCB9 0.53 6.59 0.34 1.73e-10 Neutrophil percentage of white cells; LUSC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg06022373 chr22:39101656 GTPBP1 0.88 14.59 0.62 1.24e-37 Menopause (age at onset); LUSC cis rs7267979 0.509 rs6115218 chr20:25566485 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.72 11.39 0.53 1.31e-25 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8032315 1.000 rs6227 chr15:91425232 C/T cg05469396 chr15:91419421 FURIN -0.44 -6.87 -0.35 3.07e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs17685 0.753 rs6464999 chr7:75787315 T/C cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7953508 0.506 rs12425869 chr12:93961353 A/G cg18151635 chr12:93972918 NA -0.63 -9.16 -0.45 5.26e-18 Pubertal anthropometrics; LUSC cis rs12950390 0.853 rs8071192 chr17:45856141 A/G cg06532163 chr17:45867833 NA 0.35 6.56 0.34 2.03e-10 IgG glycosylation; LUSC cis rs981844 1.000 rs2606337 chr4:154656845 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs56399783 0.901 rs7803944 chr7:2809087 G/A cg14895029 chr7:2775587 GNA12 0.48 5.95 0.31 6.61e-9 Childhood ear infection; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg24739457 chr1:205821442 NA 0.36 6.21 0.32 1.57e-9 Menarche (age at onset); LUSC cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg12935359 chr14:103987150 CKB -0.52 -8.73 -0.43 1.24e-16 Intelligence (multi-trait analysis); LUSC cis rs16937 0.711 rs11240390 chr1:205179457 A/G cg00857998 chr1:205179979 DSTYK 0.47 6.66 0.34 1.11e-10 Schizophrenia; LUSC cis rs7336332 0.598 rs76790205 chr13:28002885 C/T cg22138327 chr13:27999177 GTF3A 0.82 9.95 0.48 1.34e-20 Weight; LUSC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg23711669 chr6:146136114 FBXO30 0.85 15.91 0.66 8.01e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg11632617 chr15:75315747 PPCDC -0.5 -6.58 -0.34 1.86e-10 Blood trace element (Zn levels); LUSC cis rs7712401 0.601 rs28892 chr5:122283826 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.69 -0.47 1.01e-19 Mean platelet volume; LUSC cis rs113835537 0.877 rs2229456 chr11:66328741 A/C cg24851651 chr11:66362959 CCS 0.46 5.96 0.31 6.58e-9 Airway imaging phenotypes; LUSC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.65 -0.54 1.53e-26 Schizophrenia; LUSC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg26061582 chr7:22766209 IL6 0.49 7.3 0.37 2.14e-12 Lung cancer; LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs2625529 0.824 rs7182776 chr15:72462831 A/G cg16672083 chr15:72433130 SENP8 0.49 7.36 0.37 1.46e-12 Red blood cell count; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg10729496 chr3:10149963 C3orf24 0.55 7.21 0.37 3.79e-12 Alzheimer's disease; LUSC cis rs832540 0.866 rs252894 chr5:56224339 A/C cg12311346 chr5:56204834 C5orf35 0.45 5.7 0.3 2.69e-8 Coronary artery disease; LUSC cis rs4595586 0.545 rs4142846 chr12:39395140 C/T cg26384229 chr12:38710491 ALG10B 0.46 6.4 0.33 5.4e-10 Morning vs. evening chronotype; LUSC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.43 -6.81 -0.35 4.53e-11 Alzheimer's disease (late onset); LUSC cis rs2731664 0.792 rs2630764 chr5:176880085 C/T cg23176889 chr5:176863531 GRK6 -0.65 -13.37 -0.59 5.84e-33 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg21285383 chr16:89894308 SPIRE2 0.32 6.61 0.34 1.56e-10 Vitiligo; LUSC cis rs11645898 0.748 rs3852785 chr16:72198642 G/A cg14768367 chr16:72042858 DHODH -0.64 -6.94 -0.35 2.08e-11 Blood protein levels; LUSC cis rs748404 0.723 rs560134 chr15:43555699 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.35 0.42 1.82e-15 Lung cancer; LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg12419862 chr22:24373484 LOC391322 0.8 9.97 0.48 1.11e-20 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs2115630 1.000 rs58581703 chr15:85276935 C/T cg11189052 chr15:85197271 WDR73 -0.44 -6.37 -0.33 6.24e-10 P wave terminal force; LUSC cis rs28830936 0.841 rs4923914 chr15:42119603 C/T cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.69 -0.3 2.82e-8 Diastolic blood pressure; LUSC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Vitiligo; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09504196 chr7:148823235 ZNF425;ZNF398 0.47 6.99 0.36 1.5e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2486288 0.656 rs8039153 chr15:45579813 T/C cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.57 -0.38 3.59e-13 Glomerular filtration rate; LUSC cis rs2730245 0.592 rs2657385 chr7:158649373 A/G cg01943577 chr7:158741284 NA -0.41 -5.99 -0.31 5.38e-9 Height; LUSC cis rs72802342 0.510 rs12932952 chr16:75365486 C/T cg03315344 chr16:75512273 CHST6 0.42 6.22 0.32 1.49e-9 Advanced age-related macular degeneration; LUSC cis rs9311676 0.656 rs11130638 chr3:58405947 A/G cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.3e-10 Systemic lupus erythematosus; LUSC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg16060761 chr17:80687452 NA -0.41 -6.61 -0.34 1.49e-10 Breast cancer; LUSC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg11245181 chr6:149772854 ZC3H12D -0.3 -6.51 -0.34 2.8e-10 Dupuytren's disease; LUSC cis rs4654899 0.785 rs9426656 chr1:21505932 T/G cg01072550 chr1:21505969 NA -0.54 -8.22 -0.41 4.67e-15 Superior frontal gyrus grey matter volume; LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.25 0.45 2.77e-18 Prudent dietary pattern; LUSC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg10169327 chr19:45448959 APOC2 0.28 6.13 0.32 2.54e-9 Blood protein levels; LUSC cis rs12579753 0.810 rs10862355 chr12:82162698 C/T cg07988820 chr12:82153109 PPFIA2 -0.42 -6.21 -0.32 1.6e-9 Resting heart rate; LUSC cis rs847577 0.609 rs11768309 chr7:97773812 G/T cg21770322 chr7:97807741 LMTK2 0.55 10.12 0.48 3.46e-21 Breast cancer; LUSC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -5.77 -0.3 1.84e-8 Schizophrenia; LUSC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg26408565 chr15:76604113 ETFA -0.48 -7.54 -0.38 4.48e-13 Blood metabolite levels; LUSC cis rs9517320 0.515 rs4772101 chr13:99207554 G/A cg20487152 chr13:99095054 FARP1 -0.41 -6.87 -0.35 3.11e-11 Longevity; LUSC cis rs3806933 0.522 rs13186912 chr5:110456704 A/T cg04022379 chr5:110408740 TSLP -0.63 -9.7 -0.47 9e-20 Eosinophilic esophagitis; LUSC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg03188948 chr7:1209495 NA 0.49 6.47 0.33 3.53e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg06552810 chr11:31128660 NA -0.42 -7.42 -0.38 9.89e-13 Red blood cell count; LUSC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11890956 chr21:40555474 PSMG1 -0.75 -11.7 -0.54 9.89e-27 Menarche (age at onset); LUSC cis rs7296418 0.699 rs11057254 chr12:123794581 A/C cg05973401 chr12:123451056 ABCB9 0.53 7.8 0.39 7.89e-14 Platelet count; LUSC cis rs34779708 0.706 rs36027395 chr10:35550323 T/A cg03585969 chr10:35415529 CREM 0.53 7.32 0.37 1.88e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs950027 0.620 rs872192 chr15:45614502 A/G cg09092052 chr15:45571596 NA -0.43 -6.03 -0.31 4.27e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs3809566 1.000 rs10851721 chr15:63332383 T/C cg05507819 chr15:63340323 TPM1 0.64 8.94 0.44 2.8e-17 Platelet count; LUSC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.49 -6.64 -0.34 1.28e-10 Tonsillectomy; LUSC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg02187348 chr16:89574699 SPG7 -0.48 -7.61 -0.38 2.82e-13 Multiple myeloma (IgH translocation); LUSC cis rs11098499 0.955 rs11944880 chr4:120159334 A/G cg09307838 chr4:120376055 NA -0.68 -9.98 -0.48 1.06e-20 Corneal astigmatism; LUSC cis rs80282103 0.867 rs11250242 chr10:1100064 A/C cg23359895 chr10:1095482 IDI1 -0.66 -6.04 -0.31 4.08e-9 Glomerular filtration rate (creatinine); LUSC cis rs68170813 0.523 rs7777976 chr7:106888594 C/T cg02696742 chr7:106810147 HBP1 -0.64 -9.58 -0.46 2.35e-19 Coronary artery disease; LUSC cis rs2559856 0.903 rs10128996 chr12:102081498 G/A cg12924262 chr12:102091054 CHPT1 0.42 5.8 0.3 1.51e-8 Blood protein levels; LUSC cis rs11997175 0.574 rs4370495 chr8:33654819 G/A ch.8.33884649F chr8:33765107 NA 0.52 8.57 0.42 3.94e-16 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00841985 chr3:15901302 ANKRD28 0.54 7.58 0.38 3.4e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs113835537 0.529 rs10501397 chr11:66272976 G/T cg24851651 chr11:66362959 CCS 0.54 8.19 0.41 5.76e-15 Airway imaging phenotypes; LUSC cis rs7189233 0.911 rs72801854 chr16:53517242 G/A cg04059762 chr16:53544020 NA -0.32 -5.86 -0.31 1.09e-8 Intelligence (multi-trait analysis); LUSC trans rs877282 0.797 rs7079164 chr10:756363 A/G cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg13393036 chr8:95962371 TP53INP1 -0.32 -6.19 -0.32 1.78e-9 Type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04703749 chr11:64809102 SAC3D1 0.47 6.71 0.34 8.59e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6580649 0.941 rs11612970 chr12:48451009 T/C cg24011408 chr12:48396354 COL2A1 -0.46 -6.17 -0.32 1.95e-9 Lung cancer; LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg00945038 chr17:61921165 SMARCD2 0.51 8.67 0.43 1.94e-16 Prudent dietary pattern; LUSC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg13939156 chr17:80058883 NA 0.33 6.46 0.33 3.66e-10 Life satisfaction; LUSC cis rs7264396 0.690 rs2425165 chr20:34438059 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.65 -0.43 2.19e-16 Total cholesterol levels; LUSC cis rs4654899 0.865 rs960564 chr1:21416435 G/T cg01072550 chr1:21505969 NA -0.48 -7.06 -0.36 9.63e-12 Superior frontal gyrus grey matter volume; LUSC cis rs11958404 0.789 rs78112793 chr5:157428226 A/G cg05962755 chr5:157440814 NA 0.53 6.14 0.32 2.32e-9 IgG glycosylation; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23180600 chr3:10780722 NA 0.45 6.83 0.35 4.02e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg01416388 chr22:39784598 NA -0.43 -6.5 -0.33 2.99e-10 Post bronchodilator FEV1; LUSC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg08219700 chr8:58056026 NA 0.43 5.68 0.3 2.94e-8 Developmental language disorder (linguistic errors); LUSC cis rs2599510 0.811 rs176413 chr2:32646847 G/A cg02381751 chr2:32503542 YIPF4 -0.39 -5.68 -0.3 2.87e-8 Interleukin-18 levels; LUSC cis rs477692 1.000 rs7475154 chr10:131440584 C/T cg05714579 chr10:131428358 MGMT -0.5 -7.41 -0.38 1.03e-12 Response to temozolomide; LUSC cis rs2797685 0.945 rs1773138 chr1:7891797 C/T cg04725166 chr1:7887271 PER3 -0.45 -6.34 -0.33 7.27e-10 Crohn's disease; LUSC trans rs2420915 0.749 rs7087772 chr10:122863793 A/G cg06217504 chr4:147056211 NA 0.45 6.17 0.32 1.96e-9 Fibrinogen levels; LUSC cis rs7954584 0.635 rs11043242 chr12:122356293 G/C cg10207240 chr12:122356781 WDR66 0.46 6.47 0.33 3.5e-10 Mean corpuscular volume; LUSC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg06634786 chr22:41940651 POLR3H -0.53 -6.47 -0.33 3.42e-10 Vitiligo; LUSC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.81 -0.39 7.54e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg08807101 chr21:30365312 RNF160 -0.68 -10.44 -0.5 2.82e-22 Pancreatic cancer; LUSC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.42 6.45 0.33 3.84e-10 Prudent dietary pattern; LUSC cis rs1577917 0.771 rs9294337 chr6:86248460 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.56 0.42 4.16e-16 Response to antipsychotic treatment; LUSC cis rs6060960 0.502 rs15817 chr20:30193538 A/G cg13852791 chr20:30311386 BCL2L1 0.72 8.29 0.41 2.73e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg07148914 chr20:33460835 GGT7 0.46 6.71 0.34 8.25e-11 Height; LUSC cis rs6574644 0.958 rs7153613 chr14:81779725 C/T cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs4808199 0.689 rs12979148 chr19:19406869 T/C cg03709012 chr19:19516395 GATAD2A 0.93 9.46 0.46 5.65e-19 Nonalcoholic fatty liver disease; LUSC cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg26395211 chr5:140044315 WDR55 -0.45 -7.1 -0.36 7.41e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs7267979 0.933 rs1130694 chr20:25276297 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.87 19.86 0.74 1.73e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2235649 0.789 rs9939680 chr16:1852720 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.05 -0.31 3.93e-9 Blood metabolite levels; LUSC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.46 0.46 5.63e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs61931739 0.500 rs3924704 chr12:34557833 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.51 0.5 1.62e-22 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC cis rs3806933 0.522 rs17553936 chr5:110454681 A/G cg04022379 chr5:110408740 TSLP 0.62 9.37 0.46 1.09e-18 Eosinophilic esophagitis; LUSC trans rs9929218 1.000 rs13334294 chr16:68809278 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.72 -0.54 8.62e-27 Colorectal cancer; LUSC cis rs11958404 0.615 rs10044900 chr5:157451580 C/T cg05962755 chr5:157440814 NA -0.38 -5.76 -0.3 1.95e-8 IgG glycosylation; LUSC cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg25319279 chr11:5960081 NA -0.46 -6.51 -0.34 2.74e-10 DNA methylation (variation); LUSC cis rs11250098 0.548 rs7837038 chr8:10783074 G/A cg21775007 chr8:11205619 TDH -0.45 -6.17 -0.32 2e-9 Morning vs. evening chronotype; LUSC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg20135002 chr11:47629003 NA -0.51 -7.98 -0.4 2.41e-14 Subjective well-being; LUSC cis rs7428 0.520 rs7605890 chr2:85559525 A/C cg24342717 chr2:85555507 TGOLN2 -0.75 -11.62 -0.54 1.93e-26 Ear protrusion; LUSC cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10979 0.597 rs9496691 chr6:143910970 T/C cg25407410 chr6:143891975 LOC285740 -0.65 -8.3 -0.41 2.65e-15 Hypospadias; LUSC cis rs2413583 0.591 rs115263847 chr22:39729777 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.64 5.77 0.3 1.79e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10822866 chr20:60982408 CABLES2 -0.41 -6.46 -0.33 3.73e-10 Electrocardiographic conduction measures; LUSC cis rs6087990 0.865 rs6058859 chr20:31335157 A/G cg13636640 chr20:31349939 DNMT3B 0.98 21.32 0.76 2.89e-64 Ulcerative colitis; LUSC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg14343924 chr8:8086146 FLJ10661 -0.43 -5.95 -0.31 6.93e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg05785598 chr3:49045655 WDR6 0.35 5.81 0.3 1.43e-8 Parkinson's disease; LUSC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08704250 chr15:31115839 NA -0.47 -7.03 -0.36 1.17e-11 Huntington's disease progression; LUSC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.86 -10.74 -0.51 2.64e-23 Blood trace element (Cu levels); LUSC cis rs2235544 0.565 rs605182 chr1:54466956 A/G cg25741118 chr1:54482237 LDLRAD1 0.28 6.03 0.31 4.41e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg11764359 chr7:65958608 NA -0.62 -9.47 -0.46 5.39e-19 Aortic root size; LUSC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg06022373 chr22:39101656 GTPBP1 0.8 12.37 0.56 3.28e-29 Menopause (age at onset); LUSC trans rs6598955 0.671 rs17163868 chr1:26648381 A/G cg07461501 chr17:79650226 HGS;ARL16 0.65 9.2 0.45 3.95e-18 Obesity-related traits; LUSC cis rs34779708 0.733 rs4244997 chr10:35547254 T/C cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs17401966 0.931 rs11585794 chr1:10443867 G/A cg19773385 chr1:10388646 KIF1B -0.58 -9.66 -0.47 1.26e-19 Hepatocellular carcinoma; LUSC cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg06636001 chr8:8085503 FLJ10661 -0.65 -9.57 -0.46 2.53e-19 Mood instability; LUSC cis rs10089 1.000 rs1842006 chr5:127508687 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.62 0.54 1.97e-26 Ileal carcinoids; LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.49 8.19 0.41 5.46e-15 Lymphocyte counts; LUSC cis rs422249 0.634 rs174617 chr11:61629166 A/G cg06860612 chr11:61641270 FADS3 0.28 5.77 0.3 1.81e-8 Trans fatty acid levels; LUSC cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg11861562 chr11:117069780 TAGLN -0.4 -7.15 -0.36 5.62e-12 Blood protein levels; LUSC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg01616529 chr11:638424 DRD4 -0.35 -5.82 -0.3 1.38e-8 Systemic lupus erythematosus; LUSC cis rs9952991 0.941 rs888270 chr18:12774894 G/A cg23598886 chr18:12777645 NA -0.64 -6.29 -0.33 9.71e-10 Inflammatory skin disease; LUSC cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg19508488 chr2:152266495 RIF1 0.53 7.65 0.39 2.23e-13 Lung cancer; LUSC cis rs7592578 0.679 rs62181019 chr2:191325414 A/G cg11845111 chr2:191398756 TMEM194B -0.83 -11.14 -0.52 1.04e-24 Diastolic blood pressure; LUSC cis rs2204008 0.618 rs8186932 chr12:38338386 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.16 -0.32 2.07e-9 Bladder cancer; LUSC trans rs7628219 0.607 rs6778490 chr3:70762164 C/T cg02919122 chr3:112109797 NA 0.41 6.07 0.32 3.38e-9 Insomnia (caffeine-induced); LUSC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.69e-9 Systolic blood pressure; LUSC cis rs9788682 0.894 rs4461039 chr15:78817447 A/T cg24631222 chr15:78858424 CHRNA5 -0.8 -11.04 -0.52 2.34e-24 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7824557 0.628 rs7831346 chr8:11193530 C/T cg21293242 chr8:11204541 TDH 0.31 5.89 0.31 9.28e-9 Retinal vascular caliber; LUSC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg03233332 chr7:66118400 NA -0.4 -6.01 -0.31 4.74e-9 Aortic root size; LUSC cis rs7246967 0.611 rs56271774 chr19:22831327 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg05373962 chr22:49881684 NA -0.44 -10.55 -0.5 1.15e-22 Monocyte count;Monocyte percentage of white cells; LUSC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.39 7.62 0.38 2.67e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg10802521 chr3:52805072 NEK4 -0.55 -8.64 -0.43 2.31e-16 Bipolar disorder; LUSC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg21132104 chr15:45694354 SPATA5L1 0.59 8.14 0.41 8.1e-15 Homoarginine levels; LUSC cis rs6977660 0.714 rs12536561 chr7:19816659 G/A cg07541023 chr7:19748670 TWISTNB 0.63 6.84 0.35 3.87e-11 Thyroid stimulating hormone; LUSC cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg26384229 chr12:38710491 ALG10B 0.79 12.94 0.58 2.49e-31 Bladder cancer; LUSC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs5758511 0.508 rs2854827 chr22:42461918 G/A cg00645731 chr22:42541494 CYP2D7P1 0.48 7.96 0.4 2.8e-14 Birth weight; LUSC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg03929089 chr4:120376271 NA -1.04 -20.21 -0.74 7.12e-60 Height; LUSC cis rs782590 0.935 rs6739513 chr2:55749902 G/A cg03859395 chr2:55845619 SMEK2 0.86 16.22 0.66 4.87e-44 Metabolic syndrome; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05793193 chr7:152161912 LOC100128822 -0.47 -6.19 -0.32 1.72e-9 Hepatitis; LUSC cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg24130564 chr14:104152367 KLC1 0.46 6.39 0.33 5.65e-10 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs11098499 0.913 rs35271032 chr4:120156659 C/T cg24375607 chr4:120327624 NA 0.75 11.42 0.53 9.94e-26 Corneal astigmatism; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg00166722 chr3:10149974 C3orf24 0.62 8.47 0.42 8.07e-16 Alzheimer's disease; LUSC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg18200150 chr17:30822561 MYO1D 0.36 6.89 0.35 2.78e-11 Schizophrenia; LUSC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg22166914 chr1:53195759 ZYG11B 0.69 11.66 0.54 1.39e-26 Monocyte count; LUSC cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs12210905 1.000 rs72843611 chr6:27131382 C/T cg11502198 chr6:26597334 ABT1 -0.78 -5.65 -0.3 3.43e-8 Hip circumference adjusted for BMI; LUSC cis rs7119038 0.580 rs7123726 chr11:118694547 T/C cg19308663 chr11:118741387 NA 0.35 6.14 0.32 2.28e-9 Sjögren's syndrome; LUSC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg21573476 chr21:45109991 RRP1B -0.41 -6.66 -0.34 1.11e-10 Mean corpuscular volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20272604 chr1:231004631 C1orf198 -0.54 -6.87 -0.35 3.07e-11 Bipolar disorder and schizophrenia; LUSC trans rs2197308 0.619 rs4002730 chr12:37876400 T/C cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs6456156 0.586 rs9459853 chr6:167465774 C/A cg06454157 chr6:167490870 NA -0.28 -6.88 -0.35 2.98e-11 Primary biliary cholangitis; LUSC cis rs6430585 0.591 rs72970243 chr2:136484232 G/A cg07169764 chr2:136633963 MCM6 0.83 10.63 0.5 6.49e-23 Corneal structure; LUSC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg07636037 chr3:49044803 WDR6 1.03 18.73 0.72 5.27e-54 Parkinson's disease; LUSC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg17911788 chr17:44343683 NA 0.31 6.02 0.31 4.69e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00995911 chr19:45004602 ZNF180 -0.47 -6.12 -0.32 2.58e-9 Bipolar disorder and schizophrenia; LUSC cis rs1801251 0.929 rs10933409 chr2:233629386 A/G cg08000102 chr2:233561755 GIGYF2 0.7 11.59 0.54 2.41e-26 Coronary artery disease; LUSC cis rs929596 0.564 rs2602373 chr2:234561953 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -6.03 -0.31 4.27e-9 Total bilirubin levels in HIV-1 infection; LUSC cis rs10754283 0.934 rs6428563 chr1:90111583 T/A cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs1422110 0.616 rs1862230 chr5:85444868 C/T cg01787110 chr1:109008453 NBPF6 -0.52 -8.66 -0.43 1.98e-16 Attention function in attention deficit hyperactive disorder; LUSC cis rs2295359 1.000 rs9729046 chr1:67607082 C/G cg03340356 chr1:67600835 NA 0.44 6.82 0.35 4.39e-11 Psoriasis; LUSC trans rs3733585 0.631 rs3822236 chr4:10119961 T/G cg26043149 chr18:55253948 FECH -0.54 -7.99 -0.4 2.25e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7843479 0.601 rs10866827 chr8:21801141 G/A cg17168535 chr8:21777572 XPO7 0.84 15.49 0.65 3.71e-41 Mean corpuscular volume; LUSC trans rs9929218 1.000 rs11865026 chr16:68774283 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -12.17 -0.55 1.89e-28 Colorectal cancer; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg06026331 chr20:60912101 LAMA5 0.63 7.49 0.38 6.15e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg04722914 chr2:242255165 HDLBP;SEPT2 0.44 6.33 0.33 7.94e-10 Mosquito bite size; LUSC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg20573242 chr4:122745356 CCNA2 0.43 6.63 0.34 1.36e-10 Type 2 diabetes; LUSC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg11764359 chr7:65958608 NA 0.71 10.65 0.5 5.51e-23 Aortic root size; LUSC cis rs11756438 0.547 rs2798327 chr6:119005353 C/T cg18833306 chr6:118973337 C6orf204 0.36 5.69 0.3 2.8e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.34 -5.84 -0.3 1.24e-8 Rheumatoid arthritis; LUSC cis rs3096299 0.754 rs3102382 chr16:89409742 C/G cg02187348 chr16:89574699 SPG7 0.4 5.91 0.31 8.6e-9 Multiple myeloma (IgH translocation); LUSC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg21951975 chr1:209979733 IRF6 0.55 8.25 0.41 3.6e-15 Cleft lip with or without cleft palate; LUSC cis rs11031096 0.702 rs183484 chr11:4141132 C/A cg18678763 chr11:4115507 RRM1 0.38 5.75 0.3 2.07e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs240764 0.658 rs7451736 chr6:101189901 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.51e-10 Neuroticism; LUSC trans rs7980799 0.711 rs1482993 chr12:33594515 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.51 -0.34 2.82e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg11843238 chr5:131593191 PDLIM4 -0.34 -6.01 -0.31 4.75e-9 Breast cancer; LUSC cis rs12701220 0.690 rs10243973 chr7:1064983 T/C cg20821713 chr7:1055600 C7orf50 -0.48 -6.54 -0.34 2.29e-10 Bronchopulmonary dysplasia; LUSC cis rs6484504 0.817 rs67707190 chr11:31210500 A/G cg06552810 chr11:31128660 NA -0.41 -6.4 -0.33 5.13e-10 Red blood cell count; LUSC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg23711669 chr6:146136114 FBXO30 0.92 18.09 0.7 1.88e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs9359856 0.636 rs1980878 chr6:90314749 A/C cg13799429 chr6:90582589 CASP8AP2 0.71 7.61 0.38 2.87e-13 Bipolar disorder; LUSC cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.38 0.46 1.02e-18 Arsenic metabolism; LUSC cis rs4423214 1.000 rs12789751 chr11:71164471 G/A cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs1865760 1.000 rs3799371 chr6:25912816 A/G cg17691542 chr6:26056736 HIST1H1C -0.46 -7.09 -0.36 7.79e-12 Height; LUSC cis rs12478296 0.685 rs12473450 chr2:242991746 C/T cg06360820 chr2:242988706 NA -0.84 -10.09 -0.48 4.42e-21 Obesity-related traits; LUSC cis rs7107174 1.000 rs11603112 chr11:78073491 G/A cg02023728 chr11:77925099 USP35 0.44 6.72 0.35 7.74e-11 Testicular germ cell tumor; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg27535305 chr1:53392650 SCP2 -0.43 -8.48 -0.42 7.58e-16 Monocyte count; LUSC trans rs911555 0.755 rs2756132 chr14:103967820 C/G cg17675199 chr6:35436792 RPL10A -0.45 -6.47 -0.33 3.45e-10 Intelligence (multi-trait analysis); LUSC cis rs3755132 0.929 rs3770467 chr2:15762935 G/A cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs6456156 0.565 rs6456153 chr6:167472167 T/C cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs7267979 0.565 rs4815437 chr20:25584788 C/G cg03522245 chr20:25566470 NINL -0.4 -6.09 -0.32 3.11e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1865760 0.964 rs6932113 chr6:25913098 C/T cg16482183 chr6:26056742 HIST1H1C 0.44 6.59 0.34 1.71e-10 Height; LUSC cis rs2439831 1.000 rs689596 chr15:43761717 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09026875 chr17:60501189 METTL2A -0.42 -6.57 -0.34 1.98e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2739330 0.892 rs4822455 chr22:24255296 C/T cg06437703 chr8:37914619 EIF4EBP1 -0.59 -9.26 -0.45 2.63e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg21138405 chr5:131827807 IRF1 0.55 10.95 0.51 4.77e-24 Asthma (sex interaction); LUSC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.38 -0.33 5.85e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9790314 1.000 rs3849524 chr3:161015589 C/T cg04691961 chr3:161091175 C3orf57 -0.34 -5.78 -0.3 1.7e-8 Morning vs. evening chronotype; LUSC cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg12935359 chr14:103987150 CKB -0.51 -7.89 -0.4 4.39e-14 Body mass index; LUSC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg06481639 chr22:41940642 POLR3H 0.5 5.77 0.3 1.81e-8 Cannabis dependence symptom count; LUSC cis rs7264396 0.563 rs61191623 chr20:34219987 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.09 -0.4 1.12e-14 Total cholesterol levels; LUSC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.54e-11 Extrinsic epigenetic age acceleration; LUSC cis rs12542260 0.871 rs72713049 chr8:125484088 T/G cg27038428 chr8:125485867 RNF139 0.34 6.77 0.35 5.8e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg09913183 chr17:42254507 C17orf65;ASB16 0.54 7.94 0.4 3.06e-14 Total body bone mineral density; LUSC cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.82 -0.43 6.67e-17 Monocyte percentage of white cells; LUSC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg22508957 chr16:3507546 NAT15 -0.39 -6.14 -0.32 2.38e-9 Body mass index (adult); LUSC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11644478 chr21:40555479 PSMG1 -0.84 -15.3 -0.64 2.06e-40 Cognitive function; LUSC cis rs4908769 0.624 rs3765971 chr1:8445360 C/T cg00546117 chr1:8445545 RERE 0.31 6.33 0.33 7.83e-10 Allergy; LUSC cis rs559928 1.000 rs559928 chr11:64150370 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.62 -7.1 -0.36 7.46e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs11608355 1.000 rs10774692 chr12:109862324 G/T cg05360138 chr12:110035743 NA 0.47 6.43 0.33 4.52e-10 Neuroticism; LUSC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg25072359 chr17:41440525 NA 0.67 9.51 0.46 3.94e-19 Menopause (age at onset); LUSC cis rs8014204 0.901 rs4899536 chr14:75316614 A/G cg06637938 chr14:75390232 RPS6KL1 -0.65 -10.92 -0.51 5.98e-24 Caffeine consumption; LUSC cis rs9300255 0.568 rs1047158 chr12:123644056 C/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.17 -0.32 1.95e-9 Neutrophil percentage of white cells; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg02160419 chr7:75807660 NA -0.48 -6.19 -0.32 1.75e-9 Hepatitis; LUSC cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg16339924 chr4:17578868 LAP3 -0.56 -8.16 -0.41 7.01e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg02117656 chr17:79614917 TSPAN10 0.31 5.77 0.3 1.85e-8 Eye color traits; LUSC cis rs243505 1.000 rs243519 chr7:148423624 G/A cg09806900 chr7:148480153 CUL1 -0.48 -6.95 -0.36 1.94e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs72634258 0.945 rs12753070 chr1:8114319 C/G cg00042356 chr1:8021962 PARK7 0.84 10.02 0.48 8.04e-21 Inflammatory bowel disease; LUSC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs6754311 0.551 rs313519 chr2:136439517 A/C cg07169764 chr2:136633963 MCM6 0.55 7.29 0.37 2.32e-12 Mosquito bite size; LUSC cis rs1775715 0.870 rs11008696 chr10:32218614 G/A cg26784012 chr10:32216390 ARHGAP12 0.42 6.97 0.36 1.71e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.57 -0.5 1.04e-22 Alzheimer's disease; LUSC cis rs644799 0.648 rs1255178 chr11:95471908 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.49 6.98 0.36 1.63e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs66823261 0.778 rs2906332 chr8:194943 C/T cg27532244 chr8:182981 ZNF596;RPL23AP53 -0.53 -6.55 -0.34 2.23e-10 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs11992162 0.967 rs10108320 chr8:11832263 A/T cg21775007 chr8:11205619 TDH -0.47 -6.66 -0.34 1.12e-10 Monocyte count; LUSC cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg03146154 chr1:46216737 IPP 0.56 8.23 0.41 4.12e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.07e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs853679 0.607 rs34218844 chr6:28290647 T/C cg06606381 chr12:133084897 FBRSL1 -0.99 -9.27 -0.45 2.45e-18 Depression; LUSC cis rs4356932 1.000 rs4593163 chr4:76976056 T/C cg00809888 chr4:76862425 NAAA 0.34 5.7 0.3 2.6e-8 Blood protein levels; LUSC cis rs7674212 0.539 rs7676041 chr4:104126421 T/A cg16532752 chr4:104119610 CENPE -0.46 -6.82 -0.35 4.25e-11 Type 2 diabetes; LUSC cis rs2224391 0.910 rs2875979 chr6:5275243 A/T cg09085698 chr6:5261316 LYRM4;FARS2 0.42 6.23 0.32 1.38e-9 Height; LUSC cis rs10791097 0.694 rs2155752 chr11:130755998 C/T cg12179176 chr11:130786555 SNX19 0.85 14.78 0.63 2.23e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs28647808 0.786 rs4962137 chr9:136256826 G/T cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg13390004 chr1:15929781 NA 0.4 6.75 0.35 6.45e-11 Systolic blood pressure; LUSC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg19077165 chr18:44547161 KATNAL2 -0.41 -6.25 -0.32 1.26e-9 Personality dimensions; LUSC cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg01657329 chr11:68192670 LRP5 -0.43 -6.38 -0.33 5.86e-10 Total body bone mineral density; LUSC trans rs2315885 0.808 rs9591672 chr13:56276768 A/G cg14536096 chr20:58509298 NA -0.4 -6.05 -0.31 3.84e-9 Blood pressure; LUSC cis rs9527 0.590 rs1926037 chr10:104878010 A/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs2486288 0.656 rs11639420 chr15:45559268 A/C cg09092052 chr15:45571596 NA 0.44 6.15 0.32 2.16e-9 Glomerular filtration rate; LUSC cis rs4969178 0.641 rs4969141 chr17:76391653 C/T cg20026190 chr17:76395443 PGS1 0.33 5.72 0.3 2.32e-8 HDL cholesterol levels; LUSC cis rs10761482 0.861 rs10761491 chr10:62108718 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.1 -0.36 7.67e-12 Schizophrenia; LUSC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg04727924 chr7:799746 HEATR2 -0.55 -6.7 -0.34 8.94e-11 Cerebrospinal P-tau181p levels; LUSC trans rs7819412 0.775 rs2001329 chr8:10986859 C/T cg15556689 chr8:8085844 FLJ10661 -0.47 -7.07 -0.36 8.83e-12 Triglycerides; LUSC cis rs12928939 0.911 rs77823468 chr16:71828616 C/T cg03805757 chr16:71968109 PKD1L3 -0.46 -6.65 -0.34 1.23e-10 Post bronchodilator FEV1; LUSC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg22496380 chr5:211416 CCDC127 -0.73 -8.78 -0.43 8.85e-17 Breast cancer; LUSC cis rs1023500 0.551 rs2301521 chr22:42423110 G/C cg04733989 chr22:42467013 NAGA 0.61 9.4 0.46 8.69e-19 Schizophrenia; LUSC cis rs9303401 0.659 rs17822908 chr17:56801778 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs9517320 0.515 rs9556969 chr13:99195948 T/C cg20487152 chr13:99095054 FARP1 -0.42 -7.12 -0.36 6.7e-12 Longevity; LUSC cis rs713587 0.713 rs11125884 chr2:25239264 C/T cg15423357 chr2:25149977 NA 0.37 7.36 0.37 1.43e-12 Body mass index in non-asthmatics; LUSC cis rs2798269 0.789 rs3886357 chr13:22085965 T/C cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.77 -0.3 1.8e-8 PR segment; LUSC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.81e-12 Depression; LUSC cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg18721089 chr20:30220636 NA -0.37 -6.54 -0.34 2.35e-10 Mean corpuscular hemoglobin; LUSC cis rs7189233 0.531 rs1362429 chr16:53479084 G/C cg09728985 chr16:53543985 NA -0.31 -5.8 -0.3 1.54e-8 Intelligence (multi-trait analysis); LUSC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg21854759 chr1:92012499 NA -0.54 -9.14 -0.45 6.07e-18 Breast cancer; LUSC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -12.09 -0.55 3.73e-28 Extrinsic epigenetic age acceleration; LUSC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg24154853 chr7:158122151 PTPRN2 0.45 8.87 0.44 4.48e-17 Calcium levels; LUSC cis rs7851660 0.967 rs4743135 chr9:100599493 C/T cg13688889 chr9:100608707 NA -0.61 -10.38 -0.49 4.54e-22 Strep throat; LUSC cis rs8017423 0.874 rs4900029 chr14:90686257 T/A cg14092571 chr14:90743983 NA -0.36 -5.99 -0.31 5.36e-9 Mortality in heart failure; LUSC cis rs950881 0.867 rs72823641 chr2:102936159 T/A cg20060108 chr2:102954350 IL1RL1 0.5 6.14 0.32 2.31e-9 Allergy; LUSC cis rs2932538 0.922 rs6537744 chr1:113096746 C/G cg22162597 chr1:113214053 CAPZA1 0.7 10.11 0.48 3.74e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7808935 0.958 rs67152137 chr7:27975919 G/C cg22168087 chr7:27702803 HIBADH 0.52 6.54 0.34 2.29e-10 Prostate cancer; LUSC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -5.86 -0.31 1.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg05861140 chr6:150128134 PCMT1 -0.44 -7.01 -0.36 1.31e-11 Lung cancer; LUSC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg06484146 chr7:12443880 VWDE -0.73 -7.35 -0.37 1.58e-12 Coronary artery disease; LUSC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg04414720 chr1:150670196 GOLPH3L 0.5 7.92 0.4 3.46e-14 Melanoma; LUSC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg13607699 chr17:42295918 UBTF -0.47 -7.5 -0.38 5.74e-13 Total body bone mineral density; LUSC cis rs9300255 0.566 rs10744150 chr12:123721614 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.38 -0.33 5.87e-10 Neutrophil percentage of white cells; LUSC cis rs1728785 1.000 rs1749792 chr16:68569440 T/G cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.5 0.38 5.82e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6456156 0.586 rs12198816 chr6:167483546 G/A cg25258033 chr6:167368657 RNASET2 0.4 6.02 0.31 4.59e-9 Primary biliary cholangitis; LUSC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg08773314 chr2:239334832 ASB1 0.38 8.07 0.4 1.27e-14 Multiple system atrophy; LUSC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg08280861 chr8:58055591 NA -0.56 -6.63 -0.34 1.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs7851660 0.874 rs10122541 chr9:100628268 G/A cg13688889 chr9:100608707 NA -0.56 -8.94 -0.44 2.73e-17 Strep throat; LUSC cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg02153584 chr22:29168773 CCDC117 0.57 8.74 0.43 1.17e-16 Lymphocyte counts; LUSC cis rs7712401 0.601 rs35157167 chr5:122318201 G/C cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs7202877 0.706 rs4888375 chr16:75322356 T/C cg04384234 chr16:75411784 CFDP1 -0.62 -8.63 -0.43 2.53e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg18302933 chr2:88491318 NA -0.38 -7.48 -0.38 6.46e-13 Response to metformin (IC50); LUSC cis rs11252926 0.523 rs816596 chr10:548004 C/T cg18196295 chr10:418757 DIP2C 0.39 6.15 0.32 2.22e-9 Psychosis in Alzheimer's disease; LUSC cis rs6665290 0.935 rs1929864 chr1:227195500 T/G cg10327440 chr1:227177885 CDC42BPA -1.22 -40.37 -0.91 1.58e-130 Myeloid white cell count; LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg03188948 chr7:1209495 NA 0.68 7.14 0.36 5.96e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg05535760 chr7:792225 HEATR2 -0.78 -7.77 -0.39 1e-13 Cerebrospinal P-tau181p levels; LUSC cis rs2075371 0.501 rs1643043 chr7:134013902 C/T cg11752832 chr7:134001865 SLC35B4 0.43 6.27 0.32 1.11e-9 Mean platelet volume; LUSC cis rs7843479 1.000 rs11775444 chr8:21813018 A/G cg17168535 chr8:21777572 XPO7 0.68 10.43 0.5 3.15e-22 Mean corpuscular volume; LUSC cis rs7824557 0.614 rs2736277 chr8:11218893 C/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.75 -0.3 2.01e-8 Retinal vascular caliber; LUSC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg25643088 chr3:52874325 TMEM110 0.4 5.99 0.31 5.3e-9 Schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10598428 chr7:134001208 SLC35B4 -0.47 -6.48 -0.33 3.27e-10 Hepatitis; LUSC cis rs9393777 0.588 rs6456727 chr6:26471155 T/C cg12292205 chr6:26970375 C6orf41 -0.59 -7.36 -0.37 1.48e-12 Intelligence (multi-trait analysis); LUSC cis rs711244 0.846 rs2245109 chr2:37086197 G/C cg14987922 chr2:37194071 STRN -0.44 -6.41 -0.33 5.01e-10 Mean platelet volume; LUSC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -7.45 -0.38 8.32e-13 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg03233332 chr7:66118400 NA 0.42 6.16 0.32 2.11e-9 Aortic root size; LUSC trans rs1005277 0.505 rs10827836 chr10:38215441 A/G cg17830980 chr10:43048298 ZNF37B 0.46 7.13 0.36 6.27e-12 Extrinsic epigenetic age acceleration; LUSC cis rs7568458 0.660 rs6547623 chr2:85801964 T/A cg02493740 chr2:85810744 VAMP5 -0.51 -8.85 -0.44 5.2e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs72674100 0.881 rs72874647 chr4:97964813 A/G cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg02527881 chr3:46936655 PTH1R -0.56 -8.22 -0.41 4.41e-15 Birth weight; LUSC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg12257692 chr3:49977190 RBM6 -0.25 -7.05 -0.36 1.06e-11 Intelligence (multi-trait analysis); LUSC cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg06784218 chr1:46089804 CCDC17 -0.5 -9.59 -0.46 2.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg22484793 chr3:52261325 TLR9 0.26 6.07 0.32 3.49e-9 Electroencephalogram traits; LUSC cis rs9399401 0.845 rs263178 chr6:142865106 C/T cg03128060 chr6:142623767 GPR126 0.32 5.88 0.31 9.92e-9 Chronic obstructive pulmonary disease; LUSC cis rs4631830 0.863 rs6481329 chr10:51529746 G/A cg20129853 chr10:51489980 NA -0.34 -6.85 -0.35 3.57e-11 Prostate-specific antigen levels; LUSC cis rs6516091 0.850 rs62199232 chr20:6050137 T/G cg25325723 chr20:6104886 FERMT1 -0.67 -7.19 -0.37 4.38e-12 Abdominal aortic aneurysm; LUSC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg02569458 chr12:86230093 RASSF9 -0.49 -8.25 -0.41 3.64e-15 Major depressive disorder; LUSC cis rs35146811 0.735 rs11764176 chr7:99786964 G/T cg19116668 chr7:99932089 PMS2L1 -0.33 -5.67 -0.3 3.17e-8 Coronary artery disease; LUSC cis rs3806843 0.966 rs2563261 chr5:140137713 G/T cg26395211 chr5:140044315 WDR55 0.41 6.28 0.32 1.06e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs4906332 1.000 rs12885234 chr14:103889181 A/G cg04998671 chr14:104000505 TRMT61A -0.46 -7.29 -0.37 2.33e-12 Coronary artery disease; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg04895581 chr8:94753488 RBM12B 0.38 6.06 0.31 3.65e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17826219 0.706 rs61643715 chr17:29057762 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Body mass index; LUSC cis rs12701220 0.553 rs34062359 chr7:1139076 C/T cg20821713 chr7:1055600 C7orf50 -0.5 -6.2 -0.32 1.68e-9 Bronchopulmonary dysplasia; LUSC cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7246657 0.882 rs28623164 chr19:37913453 G/A cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs7267979 1.000 rs6115191 chr20:25440478 C/T cg08601574 chr20:25228251 PYGB 0.43 6.57 0.34 1.94e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11890956 chr21:40555474 PSMG1 0.95 16.45 0.67 5.73e-45 Cognitive function; LUSC cis rs3106136 0.967 rs12499309 chr4:95171284 G/A cg11021082 chr4:95130006 SMARCAD1 -0.36 -6.36 -0.33 6.51e-10 Capecitabine sensitivity; LUSC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg23630131 chr7:65973040 NA -0.21 -5.75 -0.3 2e-8 Aortic root size; LUSC cis rs17253792 0.822 rs74412558 chr14:56054311 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs17824933 1.000 rs916813 chr11:60764028 A/G cg16817237 chr11:60793675 NA 0.4 6.32 0.33 8.24e-10 Multiple sclerosis; LUSC cis rs9309473 1.000 rs7580825 chr2:73635148 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.81 -0.35 4.53e-11 Metabolite levels; LUSC cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg25173405 chr17:45401733 C17orf57 0.36 5.7 0.3 2.58e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg24088639 chr11:34937564 PDHX;APIP -0.49 -7.31 -0.37 2.01e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg20066347 chr14:69620129 DCAF5 0.4 6.15 0.32 2.26e-9 N-glycan levels; LUSC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg27165867 chr14:105738592 BRF1 -0.52 -7.45 -0.38 8.05e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7180079 1.000 rs12148898 chr15:64643691 T/C cg08069370 chr15:64387884 SNX1 0.54 5.91 0.31 8.34e-9 Monocyte count; LUSC cis rs540254 0.619 rs1556517 chr1:160771761 C/A cg20255094 chr1:160771763 LY9 0.55 6.55 0.34 2.17e-10 Blood protein levels; LUSC cis rs1559088 0.948 rs12608825 chr19:33581219 C/T cg27124370 chr19:33622961 WDR88 -0.56 -7.26 -0.37 2.79e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs9329221 0.736 rs2001337 chr8:10251154 G/A cg06636001 chr8:8085503 FLJ10661 0.57 7.81 0.39 7.59e-14 Neuroticism; LUSC cis rs136211 0.640 rs9610495 chr22:36760838 G/A cg10790723 chr22:36903033 FOXRED2 0.4 5.83 0.3 1.3e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs611744 0.647 rs587340 chr8:109246032 C/A cg21045802 chr8:109455806 TTC35 0.42 6.45 0.33 3.9e-10 Dupuytren's disease; LUSC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg18252515 chr7:66147081 NA -1.19 -12.97 -0.58 2.03e-31 Diabetic kidney disease; LUSC cis rs9359856 0.510 rs4235839 chr6:90472410 A/G cg13799429 chr6:90582589 CASP8AP2 0.92 11.07 0.52 1.81e-24 Bipolar disorder; LUSC cis rs4704187 0.687 rs1477933 chr5:74437153 G/A cg03227963 chr5:74354835 NA 0.31 6.77 0.35 5.75e-11 Response to amphetamines; LUSC cis rs977987 0.742 rs34624768 chr16:75331572 G/A cg03315344 chr16:75512273 CHST6 0.47 8.82 0.43 6.26e-17 Dupuytren's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23187103 chr8:128748481 MYC -0.43 -6.24 -0.32 1.3e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg00310523 chr12:86230176 RASSF9 0.45 8.06 0.4 1.42e-14 Major depressive disorder; LUSC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg08847533 chr14:75593920 NEK9 0.8 15.08 0.64 1.54e-39 Height; LUSC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs561341 0.654 rs6505265 chr17:30172580 C/T cg13647721 chr17:30228624 UTP6 -0.58 -6.02 -0.31 4.64e-9 Hip circumference adjusted for BMI; LUSC cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg05347473 chr6:146136440 FBXO30 0.45 7.79 0.39 8.26e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7586879 1.000 rs12713419 chr2:25121853 G/A cg15423357 chr2:25149977 NA 0.35 6.49 0.33 3.09e-10 Body mass index; LUSC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg03452623 chr4:187889614 NA -0.87 -17.63 -0.69 1.28e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs3796619 1.000 rs1466214 chr4:1073760 C/T cg27284194 chr4:1044797 NA 0.48 7.84 0.39 6.24e-14 Recombination rate (males); LUSC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.48 0.38 6.75e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg12365402 chr11:9010492 NRIP3 0.46 8.46 0.42 8.76e-16 Hemoglobin concentration; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.45 5.88 0.31 1.01e-8 Renal function-related traits (BUN); LUSC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg02951883 chr7:2050386 MAD1L1 -0.45 -7.8 -0.39 8e-14 Schizophrenia; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg07703079 chr11:430292 ANO9 -0.63 -6.78 -0.35 5.53e-11 Body mass index; LUSC cis rs7582720 0.943 rs114372659 chr2:203715514 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs12195417 0.524 rs1171106 chr6:84214735 T/G cg08257003 chr6:84140564 ME1 -0.28 -6.34 -0.33 7.62e-10 Schizophrenia; LUSC cis rs7819412 0.838 rs3021494 chr8:10983534 A/G cg21775007 chr8:11205619 TDH -0.48 -7.05 -0.36 1.03e-11 Triglycerides; LUSC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg15448220 chr1:150897856 SETDB1 0.41 6.1 0.32 2.95e-9 Melanoma; LUSC trans rs11098499 0.615 rs59867181 chr4:120556467 C/T cg25214090 chr10:38739885 LOC399744 -0.4 -6.42 -0.33 4.56e-10 Corneal astigmatism; LUSC trans rs683250 0.701 rs11607886 chr11:83204132 T/C cg26617787 chr11:123396133 GRAMD1B 0.29 5.97 0.31 5.95e-9 Subcortical brain region volumes; LUSC cis rs2073300 0.609 rs6132610 chr20:23403987 C/T cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg12311346 chr5:56204834 C5orf35 -0.7 -10.75 -0.51 2.44e-23 Coronary artery disease; LUSC cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs977987 0.778 rs11862719 chr16:75431708 T/A cg03315344 chr16:75512273 CHST6 0.48 9.12 0.45 6.97e-18 Dupuytren's disease; LUSC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg02569458 chr12:86230093 RASSF9 0.58 9.82 0.47 3.54e-20 Major depressive disorder; LUSC cis rs12681288 0.523 rs73176528 chr8:961962 G/A cg04851639 chr8:1020857 NA -0.4 -8.05 -0.4 1.45e-14 Schizophrenia; LUSC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg03609598 chr5:56110824 MAP3K1 -0.39 -5.67 -0.3 3.12e-8 Initial pursuit acceleration; LUSC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.68 -0.3 2.93e-8 Tonsillectomy; LUSC cis rs9640161 0.617 rs56019796 chr7:150009226 T/C cg27494647 chr7:150038898 RARRES2 0.45 7.17 0.37 4.97e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg09517075 chr8:22133004 PIWIL2 0.43 8.46 0.42 8.31e-16 Hypertriglyceridemia; LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg23758822 chr17:41437982 NA 1.06 20.2 0.74 7.16e-60 Menopause (age at onset); LUSC cis rs908922 0.676 rs578382 chr1:152514054 A/G cg20991723 chr1:152506922 NA -0.49 -9.28 -0.45 2.21e-18 Hair morphology; LUSC trans rs3858145 0.588 rs115455464 chr10:70038498 T/C cg04882175 chr6:131122610 NA -0.65 -8.81 -0.43 7.04e-17 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); LUSC cis rs2580764 0.565 rs2044291 chr2:55247954 A/G cg09592903 chr2:55203963 RTN4 -0.5 -10.14 -0.49 2.98e-21 Mean platelet volume; LUSC cis rs11112613 0.775 rs10861462 chr12:106019898 C/T cg03607813 chr12:105948248 NA -0.43 -6.09 -0.32 3.14e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs1348850 0.872 rs10165785 chr2:178293295 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.9 0.4 4.07e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.16 -0.32 2.12e-9 Total body bone mineral density; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.96e-29 Prudent dietary pattern; LUSC cis rs10504229 0.679 rs16921687 chr8:58053514 T/C cg21724239 chr8:58056113 NA 0.56 6.66 0.34 1.13e-10 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC trans rs61931739 0.500 rs10844789 chr12:34202279 C/G cg13010199 chr12:38710504 ALG10B 0.56 8.62 0.43 2.75e-16 Morning vs. evening chronotype; LUSC trans rs62238980 0.522 rs117246042 chr22:32454080 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs477692 0.647 rs11016853 chr10:131443990 A/G cg05714579 chr10:131428358 MGMT -0.66 -10.73 -0.51 2.83e-23 Response to temozolomide; LUSC cis rs858239 0.601 rs6962526 chr7:23158233 G/A cg23682824 chr7:23144976 KLHL7 0.39 5.68 0.3 2.92e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.7 0.47 9.08e-20 Bipolar disorder; LUSC cis rs977987 0.806 rs11149832 chr16:75462713 C/T cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg17724175 chr1:150552817 MCL1 0.36 6.5 0.34 2.95e-10 Melanoma; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg17168838 chr19:54663528 LENG1 0.38 6.33 0.33 7.85e-10 Triglycerides; LUSC trans rs877282 0.853 rs7069720 chr10:754487 A/G cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs7617773 0.780 rs13085251 chr3:48340045 C/T cg11946769 chr3:48343235 NME6 0.88 14.29 0.62 1.69e-36 Coronary artery disease; LUSC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg17143192 chr8:8559678 CLDN23 0.66 9.61 0.47 1.84e-19 Obesity-related traits; LUSC cis rs1451375 0.572 rs896309 chr7:50545022 A/G cg18232548 chr7:50535776 DDC -0.53 -7.42 -0.38 9.56e-13 Malaria; LUSC cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg13057898 chr1:3703894 LRRC47 0.49 8.61 0.43 3.03e-16 Red cell distribution width; LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.28e-9 Menopause (age at onset); LUSC cis rs977987 0.806 rs4888420 chr16:75462998 G/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs4409675 0.527 rs12067053 chr1:28227122 T/G cg23691781 chr1:28212827 C1orf38 0.32 7.65 0.39 2.21e-13 Corneal astigmatism; LUSC cis rs208520 1.000 rs12212063 chr6:66985148 C/A cg07460842 chr6:66804631 NA 0.92 12.02 0.55 6.84e-28 Exhaled nitric oxide output; LUSC cis rs10193935 1.000 rs10171023 chr2:42407093 G/C cg27598129 chr2:42591480 NA -0.58 -7.86 -0.4 5.18e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs861020 0.771 rs126280 chr1:210019824 A/G cg05527609 chr1:210001259 C1orf107 0.94 13.68 0.6 3.93e-34 Orofacial clefts; LUSC cis rs8017423 0.935 rs17188598 chr14:90722473 A/T cg14092571 chr14:90743983 NA -0.38 -6.33 -0.33 8.03e-10 Mortality in heart failure; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01145475 chr6:7313460 SSR1 0.76 6.43 0.33 4.51e-10 Cognitive performance; LUSC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg14552801 chr7:65878734 NA 0.44 6.6 0.34 1.6e-10 Aortic root size; LUSC cis rs4253772 0.938 rs45550937 chr22:46638128 C/G cg18190219 chr22:46762943 CELSR1 -0.48 -5.81 -0.3 1.45e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs977987 0.806 rs4888425 chr16:75476363 T/C cg03315344 chr16:75512273 CHST6 0.49 9.5 0.46 4.32e-19 Dupuytren's disease; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg11494091 chr17:61959527 GH2 0.7 15.06 0.64 1.7e-39 Prudent dietary pattern; LUSC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg03264133 chr6:25882463 NA -0.39 -6.9 -0.35 2.67e-11 Height; LUSC cis rs9527 0.590 rs10883834 chr10:104881402 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.35 0.37 1.58e-12 Electroencephalogram traits; LUSC cis rs1348850 0.526 rs2141157 chr2:178374112 C/T cg22681709 chr2:178499509 PDE11A -0.47 -6.88 -0.35 2.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11690935 1.000 rs1554166 chr2:172541609 G/T cg13550731 chr2:172543902 DYNC1I2 -0.9 -15.03 -0.64 2.41e-39 Schizophrenia; LUSC cis rs62400317 0.859 rs10948201 chr6:45093494 A/C cg20913747 chr6:44695427 NA 0.46 7.32 0.37 1.89e-12 Total body bone mineral density; LUSC cis rs7808935 0.628 rs9791862 chr7:27950760 G/A cg22168087 chr7:27702803 HIBADH 0.68 8.08 0.4 1.23e-14 Prostate cancer; LUSC cis rs3087591 0.879 rs12103564 chr17:29607243 A/T cg24425628 chr17:29625626 OMG;NF1 -0.63 -9.03 -0.44 1.43e-17 Hip circumference; LUSC cis rs796364 0.625 rs1369843 chr2:201088171 A/G cg17644776 chr2:200775616 C2orf69 0.42 5.83 0.3 1.32e-8 Schizophrenia; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg15790184 chr11:494944 RNH1 0.61 6.51 0.34 2.82e-10 Body mass index; LUSC cis rs3862030 0.720 rs7341995 chr10:104223831 G/A cg05855489 chr10:104503620 C10orf26 0.52 7.95 0.4 2.91e-14 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23248424 chr5:179741104 GFPT2 -0.54 -8.53 -0.42 5.28e-16 Height; LUSC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg06484146 chr7:12443880 VWDE -0.68 -7.23 -0.37 3.41e-12 Coronary artery disease; LUSC trans rs7944735 0.690 rs7927682 chr11:47947658 T/C cg15704280 chr7:45808275 SEPT13 0.61 6.22 0.32 1.48e-9 Intraocular pressure; LUSC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg08564027 chr20:61660810 NA -0.74 -12.66 -0.57 2.9e-30 Prostate cancer (SNP x SNP interaction); LUSC cis rs7712401 0.601 rs30054 chr5:122301999 A/G cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs11190604 1.000 rs2495736 chr10:102338410 T/C cg07080220 chr10:102295463 HIF1AN 0.67 8.74 0.43 1.13e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7769051 1.000 rs9493445 chr6:133125409 C/T cg07930552 chr6:133119739 C6orf192 0.79 10.32 0.49 7.22e-22 Type 2 diabetes nephropathy; LUSC cis rs4919087 0.962 rs10882883 chr10:99013312 A/G cg25902810 chr10:99078978 FRAT1 0.46 6.72 0.35 7.82e-11 Monocyte count; LUSC cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg23093090 chr10:104574429 C10orf26 -0.34 -6.25 -0.32 1.26e-9 Arsenic metabolism; LUSC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg20684491 chr1:25596433 NA 0.39 6.19 0.32 1.79e-9 Erythrocyte sedimentation rate; LUSC cis rs17270561 0.525 rs10484432 chr6:26008876 G/A cg17042849 chr6:26104293 HIST1H4C -0.64 -7.35 -0.37 1.57e-12 Iron status biomarkers; LUSC cis rs10754283 0.967 rs4658302 chr1:90103336 A/G cg21401794 chr1:90099060 LRRC8C 0.66 9.93 0.48 1.53e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg08508325 chr11:3079039 CARS 0.36 7.96 0.4 2.66e-14 Calcium levels; LUSC cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.6 -8.06 -0.4 1.41e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4478858 0.718 rs10914329 chr1:31688441 T/A cg00250761 chr1:31883323 NA 0.36 9.37 0.46 1.15e-18 Alcohol dependence; LUSC cis rs4805272 0.512 rs8106166 chr19:29339578 A/G cg04546413 chr19:29218101 NA -0.57 -7.42 -0.38 9.53e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs1691799 0.867 rs1027401 chr12:66760892 C/G cg16791601 chr12:66731901 HELB -0.68 -12.0 -0.55 7.95e-28 White blood cell count (basophil); LUSC cis rs8016982 0.662 rs1864169 chr14:81670033 G/T cg01989461 chr14:81687754 GTF2A1 0.5 6.57 0.34 1.92e-10 Schizophrenia; LUSC cis rs2637266 0.756 rs2245335 chr10:78553265 T/C cg18941641 chr10:78392320 NA 0.37 6.7 0.34 8.79e-11 Pulmonary function; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.36 0.46 1.17e-18 Prudent dietary pattern; LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg23758822 chr17:41437982 NA 1.05 20.03 0.74 3.41e-59 Menopause (age at onset); LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg10729496 chr3:10149963 C3orf24 0.54 7.18 0.37 4.44e-12 Alzheimer's disease; LUSC cis rs4363385 0.747 rs1415961 chr1:152973464 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.83 -0.39 6.43e-14 Inflammatory skin disease; LUSC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg13114125 chr14:105738426 BRF1 -0.9 -15.31 -0.64 1.85e-40 Mean platelet volume;Platelet distribution width; LUSC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg22467129 chr15:76604101 ETFA -0.45 -7.24 -0.37 3.05e-12 Blood metabolite levels; LUSC cis rs5758659 0.904 rs5758653 chr22:42613485 G/T cg04733989 chr22:42467013 NAGA 0.4 6.44 0.33 4.08e-10 Cognitive function; LUSC cis rs9868809 0.881 rs13063312 chr3:48661985 G/A cg00383909 chr3:49044727 WDR6 1.04 9.33 0.45 1.5e-18 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7824557 0.564 rs34964435 chr8:11230206 G/T cg21775007 chr8:11205619 TDH -0.68 -10.93 -0.51 5.46e-24 Retinal vascular caliber; LUSC cis rs1448094 0.967 rs2405789 chr12:86320466 C/T cg18827107 chr12:86230957 RASSF9 0.4 5.89 0.31 9.32e-9 Major depressive disorder; LUSC cis rs8060686 0.641 rs55725810 chr16:68189636 C/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08613594 chr2:201374742 KCTD18 -0.39 -6.12 -0.32 2.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7224314 1.000 rs62084078 chr17:65386886 T/C cg01507342 chr17:65387096 PITPNC1 -0.45 -7.93 -0.4 3.28e-14 Diisocyanate-induced asthma; LUSC cis rs12908161 1.000 rs35524990 chr15:85258203 T/C cg12863693 chr15:85201151 NMB 0.42 8.76 0.43 1.02e-16 Schizophrenia; LUSC cis rs9467711 0.606 rs28362606 chr6:26365586 T/C cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs66887589 0.774 rs9307477 chr4:120421809 G/A cg09307838 chr4:120376055 NA 0.5 7.52 0.38 5.11e-13 Diastolic blood pressure; LUSC trans rs3733585 0.673 rs9994266 chr4:9954450 C/T cg26043149 chr18:55253948 FECH -0.47 -7.37 -0.37 1.35e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg13939156 chr17:80058883 NA -0.33 -6.39 -0.33 5.53e-10 Life satisfaction; LUSC cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg10645314 chr2:3704589 ALLC 0.62 10.25 0.49 1.32e-21 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1577917 1.000 rs13217384 chr6:86720000 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -8.03 -0.4 1.63e-14 Response to antipsychotic treatment; LUSC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs208520 0.770 rs2224422 chr6:66883993 G/A cg07460842 chr6:66804631 NA -1.05 -15.66 -0.65 7.51e-42 Exhaled nitric oxide output; LUSC cis rs317689 0.718 rs645026 chr12:69757931 G/A cg11871910 chr12:69753446 YEATS4 0.6 7.9 0.4 4.06e-14 Response to diuretic therapy; LUSC cis rs593982 0.920 rs488170 chr11:65481544 T/C cg08755490 chr11:65554678 OVOL1 1.5 13.43 0.59 3.43e-33 Atopic dermatitis; LUSC cis rs950027 0.549 rs1719250 chr15:45609773 A/G cg09092052 chr15:45571596 NA -0.45 -6.59 -0.34 1.73e-10 Response to fenofibrate (adiponectin levels); LUSC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg05623727 chr3:50126028 RBM5 -0.34 -6.36 -0.33 6.62e-10 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.13 0.55 2.67e-28 Motion sickness; LUSC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.48 0.42 7.28e-16 Menarche (age at onset); LUSC cis rs2204008 0.643 rs1315347 chr12:38162494 C/T cg13010199 chr12:38710504 ALG10B -0.51 -7.71 -0.39 1.44e-13 Bladder cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13119284 chr22:32870628 FBXO7 0.76 6.25 0.32 1.23e-9 Cognitive performance; LUSC cis rs7647973 0.593 rs55997059 chr3:49858661 A/T cg03060546 chr3:49711283 APEH -0.59 -6.99 -0.36 1.49e-11 Menarche (age at onset); LUSC trans rs9291683 0.546 rs6820188 chr4:10051655 C/T cg26043149 chr18:55253948 FECH 0.46 6.81 0.35 4.6e-11 Bone mineral density; LUSC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11644478 chr21:40555479 PSMG1 0.88 14.77 0.63 2.32e-38 Cognitive function; LUSC cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg13010199 chr12:38710504 ALG10B 0.64 9.83 0.47 3.29e-20 Bladder cancer; LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg26597838 chr10:835615 NA 1.07 13.74 0.6 2.38e-34 Eosinophil percentage of granulocytes; LUSC cis rs4285028 0.948 rs7640872 chr3:121697168 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.71 -9.16 -0.45 5.31e-18 Multiple sclerosis; LUSC cis rs2294693 0.947 rs10155663 chr6:40994301 T/G cg14769373 chr6:40998127 UNC5CL -0.53 -7.89 -0.4 4.22e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs9309473 1.000 rs11674602 chr2:73723185 A/T cg20560298 chr2:73613845 ALMS1 -0.49 -7.02 -0.36 1.24e-11 Metabolite levels; LUSC cis rs4148883 0.629 rs10009145 chr4:100047929 G/A cg12011299 chr4:100065546 ADH4 0.51 8.41 0.42 1.19e-15 Alcohol dependence; LUSC cis rs9388451 0.839 rs980014 chr6:126068001 T/G cg05901451 chr6:126070800 HEY2 -0.96 -18.88 -0.72 1.31e-54 Brugada syndrome; LUSC cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg06636001 chr8:8085503 FLJ10661 0.75 11.96 0.55 1.07e-27 Neuroticism; LUSC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg19318889 chr4:1322082 MAEA 0.45 7.28 0.37 2.42e-12 Obesity-related traits; LUSC trans rs7937682 0.855 rs527078 chr11:111479713 T/C cg18187862 chr3:45730750 SACM1L 0.54 7.02 0.36 1.24e-11 Primary sclerosing cholangitis; LUSC cis rs9463078 0.547 rs2038557 chr6:44740471 G/A cg25276700 chr6:44698697 NA 0.3 6.33 0.33 7.67e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg26354017 chr1:205819088 PM20D1 -0.48 -7.34 -0.37 1.69e-12 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26316083 chr13:48808187 ITM2B -0.42 -6.2 -0.32 1.67e-9 Electrocardiographic conduction measures; LUSC cis rs2237234 0.580 rs7763910 chr6:26472655 C/T cg05738196 chr6:26577821 NA -0.55 -8.52 -0.42 5.73e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs68170813 0.559 rs3779498 chr7:106923158 C/G cg02696742 chr7:106810147 HBP1 -0.65 -9.79 -0.47 4.7e-20 Coronary artery disease; LUSC cis rs1185460 0.967 rs1784460 chr11:118938371 A/T cg01677386 chr11:118938358 VPS11 0.49 7.01 0.36 1.35e-11 Coronary artery disease; LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg07677032 chr17:61819896 STRADA -0.51 -8.55 -0.42 4.47e-16 Prudent dietary pattern; LUSC cis rs6977660 0.714 rs6977079 chr7:19818207 G/A cg07541023 chr7:19748670 TWISTNB 0.6 6.51 0.34 2.7e-10 Thyroid stimulating hormone; LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg00149659 chr3:10157352 C3orf10 0.98 14.19 0.61 4.3e-36 Alzheimer's disease; LUSC cis rs477692 0.967 rs519690 chr10:131424033 G/A cg11019008 chr10:131425282 MGMT 0.39 5.84 0.3 1.26e-8 Response to temozolomide; LUSC cis rs6542838 0.704 rs13011428 chr2:99528305 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.01 -0.36 1.35e-11 Fear of minor pain; LUSC cis rs10751667 0.643 rs10902234 chr11:935578 A/G ch.11.42038R chr11:967971 AP2A2 0.43 6.42 0.33 4.63e-10 Alzheimer's disease (late onset); LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.0 -0.68 3.84e-47 Gut microbiome composition (summer); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09130549 chr8:97247213 UQCRB -0.42 -6.09 -0.32 3.17e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs61931739 0.817 rs11833948 chr12:34276942 G/T cg06521331 chr12:34319734 NA -0.38 -6.65 -0.34 1.2e-10 Morning vs. evening chronotype; LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg08470875 chr2:26401718 FAM59B -0.67 -8.83 -0.44 5.86e-17 Gut microbiome composition (summer); LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 7.9e-43 Menopause (age at onset); LUSC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.17e-22 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19436502 chr3:141944077 GK5 -0.44 -6.7 -0.34 8.92e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2250402 0.510 rs8031319 chr15:40323692 A/G cg20059928 chr15:40361485 NA -0.51 -6.05 -0.31 3.94e-9 Corneal curvature; LUSC cis rs7590368 0.715 rs56141717 chr2:10958989 C/T cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg08085267 chr17:45401833 C17orf57 0.54 8.83 0.44 6.01e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11098499 0.913 rs10010696 chr4:120164303 T/C cg09307838 chr4:120376055 NA 0.72 10.14 0.49 3.12e-21 Corneal astigmatism; LUSC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg08270630 chr22:50330655 NA -0.4 -6.07 -0.32 3.4e-9 Schizophrenia; LUSC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg11843238 chr5:131593191 PDLIM4 0.37 6.45 0.33 3.91e-10 Breast cancer; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs5769765 1.000 rs8184990 chr22:50273174 A/G cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.11 0.36 6.97e-12 Rheumatoid arthritis; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg00149659 chr3:10157352 C3orf10 0.89 12.13 0.55 2.59e-28 Alzheimer's disease; LUSC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg18230493 chr5:56204884 C5orf35 -0.57 -8.95 -0.44 2.45e-17 Coronary artery disease; LUSC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg02782426 chr3:40428986 ENTPD3 0.33 6.24 0.32 1.36e-9 Renal cell carcinoma; LUSC cis rs71403859 0.730 rs17356206 chr16:71736359 G/C cg08717414 chr16:71523259 ZNF19 -0.66 -7.26 -0.37 2.69e-12 Post bronchodilator FEV1; LUSC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg08680598 chr22:49984980 NA -0.34 -6.36 -0.33 6.69e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11428934 1 rs11428934 chr19:49144245 T/TG cg06677660 chr19:49140777 SEC1;DBP 0.46 6.02 0.31 4.59e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Granulocyte count; LUSC cis rs10504073 0.584 rs56074306 chr8:49940282 C/T cg00325661 chr8:49890786 NA 0.7 11.18 0.52 7.2e-25 Blood metabolite ratios; LUSC cis rs1371867 0.846 rs1788199 chr8:101292854 A/G cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.54e-15 Atrioventricular conduction; LUSC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg12311346 chr5:56204834 C5orf35 -0.98 -14.24 -0.61 2.81e-36 Initial pursuit acceleration; LUSC cis rs2041895 0.527 rs10861678 chr12:107319661 C/T cg13944111 chr12:107296891 NA 0.36 6.44 0.33 4.24e-10 Glaucoma (low intraocular pressure); LUSC cis rs4953404 0.588 rs1319499 chr2:46894846 T/A cg09399716 chr2:46890238 NA -0.31 -6.84 -0.35 3.82e-11 Pulse pressure (alcohol consumption interaction); LUSC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg21724239 chr8:58056113 NA 0.78 8.01 0.4 1.89e-14 Developmental language disorder (linguistic errors); LUSC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg18252515 chr7:66147081 NA -1.23 -14.17 -0.61 5.08e-36 Gout; LUSC cis rs9394159 0.583 rs6457738 chr6:33617464 C/T cg14003231 chr6:33640908 ITPR3 -0.45 -8.94 -0.44 2.65e-17 Graves' disease; LUSC cis rs3947 0.756 rs1613883 chr8:11699632 T/A cg00262122 chr8:11665843 FDFT1 -0.48 -5.78 -0.3 1.69e-8 Blood protein levels; LUSC cis rs9902453 0.765 rs9890747 chr17:28007442 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.34 0.53 2.01e-25 Coffee consumption (cups per day); LUSC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg20546810 chr20:2489835 ZNF343 0.4 6.05 0.31 3.95e-9 Schizophrenia; LUSC cis rs7937682 0.556 rs7108048 chr11:111352299 T/C cg09085632 chr11:111637200 PPP2R1B 0.44 5.84 0.3 1.25e-8 Primary sclerosing cholangitis; LUSC cis rs7917772 0.582 rs10786682 chr10:104318322 A/C cg05855489 chr10:104503620 C10orf26 0.47 7.21 0.37 3.8e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg14004847 chr7:1930337 MAD1L1 -0.47 -7.19 -0.37 4.38e-12 Bipolar disorder and schizophrenia; LUSC trans rs4773505 0.745 rs9515619 chr13:90419085 C/G cg07901206 chr2:129250690 NA 0.43 6.14 0.32 2.29e-9 Loneliness (multivariate analysis); LUSC cis rs9811920 0.683 rs16841874 chr3:99720564 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.33 -6.16 -0.32 2.05e-9 Axial length; LUSC cis rs9815354 1.000 rs1717024 chr3:41984888 G/T cg03022575 chr3:42003672 ULK4 -0.51 -6.11 -0.32 2.82e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs9420 0.961 rs576859 chr11:57480623 A/C cg02958346 chr11:57425731 CLP1 0.41 6.07 0.32 3.56e-9 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17079137 chr17:27070735 TRAF4 0.4 5.95 0.31 6.84e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.16e-9 Diabetic kidney disease; LUSC cis rs12760731 0.720 rs12060844 chr1:178280816 T/C cg00404053 chr1:178313656 RASAL2 0.57 6.56 0.34 2.07e-10 Obesity-related traits; LUSC cis rs1797081 1.000 rs2603807 chr10:16872797 A/G cg23933602 chr10:16859644 RSU1 1.01 20.96 0.75 7.7e-63 Platelet distribution width; LUSC cis rs11603020 0.950 rs11229067 chr11:57374946 A/C cg23127183 chr11:57508653 C11orf31 0.43 5.85 0.3 1.2e-8 Blood protein levels; LUSC cis rs17092148 1.000 rs3787223 chr20:33331385 C/T cg16810054 chr20:33298113 TP53INP2 0.4 6.38 0.33 5.99e-10 Neuroticism; LUSC trans rs6600671 0.899 rs2319971 chr1:121226982 A/C cg00646200 chr1:148855367 NA 0.46 7.47 0.38 6.89e-13 Hip geometry; LUSC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg17385448 chr1:15911702 AGMAT 0.35 5.89 0.31 9.59e-9 Systolic blood pressure; LUSC cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg26384229 chr12:38710491 ALG10B 0.92 15.75 0.65 3.5e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs17621444 0.522 rs4751761 chr10:121796742 A/C cg02041677 chr10:121771263 NA 0.33 6.18 0.32 1.92e-9 IgG glycosylation; LUSC cis rs427394 0.659 rs274693 chr5:6734162 G/A cg10857441 chr5:6722123 POLS -0.44 -8.16 -0.41 7.07e-15 Menopause (age at onset); LUSC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg03806693 chr22:41940476 POLR3H -1.02 -13.77 -0.6 1.74e-34 Vitiligo; LUSC cis rs6121246 0.522 rs6088736 chr20:30195166 C/G cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg17366294 chr4:99064904 C4orf37 0.61 10.91 0.51 6.72e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.41 -0.33 5.09e-10 Total body bone mineral density; LUSC cis rs12579753 1.000 rs7963577 chr12:82174115 T/C cg07988820 chr12:82153109 PPFIA2 -0.44 -6.2 -0.32 1.7e-9 Resting heart rate; LUSC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg26116260 chr4:7069785 GRPEL1 0.88 10.7 0.51 3.48e-23 Monocyte percentage of white cells; LUSC cis rs225245 0.782 rs321601 chr17:33892087 A/C cg05299278 chr17:33885742 SLFN14 -0.31 -6.8 -0.35 4.87e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg17279839 chr7:150038598 RARRES2 0.54 7.99 0.4 2.22e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs911555 0.539 rs4374097 chr14:104072766 A/C cg12935359 chr14:103987150 CKB -0.52 -7.96 -0.4 2.78e-14 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg17264618 chr3:40429014 ENTPD3 0.32 7.01 0.36 1.34e-11 Renal cell carcinoma; LUSC cis rs7769051 1.000 rs10484629 chr6:133117870 A/C cg22852734 chr6:133119734 C6orf192 1.22 14.19 0.61 4.37e-36 Type 2 diabetes nephropathy; LUSC trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg20587970 chr11:113659929 NA 1.24 12.93 0.58 2.82e-31 Hip circumference adjusted for BMI; LUSC cis rs4065321 0.522 rs11078930 chr17:38141955 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.7 12.4 0.56 2.64e-29 White blood cell count (basophil);White blood cell count; LUSC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg21984481 chr17:79567631 NPLOC4 -0.73 -15.53 -0.65 2.54e-41 Eye color traits; LUSC cis rs11098499 0.648 rs2002047 chr4:120257228 A/G cg09307838 chr4:120376055 NA 0.69 10.47 0.5 2.2e-22 Corneal astigmatism; LUSC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.8 -0.35 4.73e-11 Lung cancer; LUSC cis rs72781680 0.948 rs72781652 chr2:24213754 G/A cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.29e-21 Lymphocyte counts; LUSC cis rs7584330 0.554 rs4420668 chr2:238444793 G/A cg14458575 chr2:238380390 NA 0.43 5.73 0.3 2.3e-8 Prostate cancer; LUSC cis rs17095355 0.605 rs58154613 chr10:111633966 C/T cg00817464 chr10:111662876 XPNPEP1 -0.58 -6.77 -0.35 5.95e-11 Biliary atresia; LUSC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7208859 0.573 rs55661352 chr17:29045628 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.08 0.36 8.42e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.1 0.64 1.19e-39 Intelligence (multi-trait analysis); LUSC cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg24450063 chr1:156163899 SLC25A44 1.04 16.82 0.68 2.06e-46 Testicular germ cell tumor; LUSC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg14582100 chr15:45693742 SPATA5L1 0.59 10.64 0.5 5.61e-23 Homoarginine levels; LUSC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg25643088 chr3:52874325 TMEM110 0.4 6.14 0.32 2.37e-9 Schizophrenia; LUSC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg09263875 chr16:632152 PIGQ 0.71 13.2 0.59 2.71e-32 Height; LUSC cis rs9457247 0.668 rs2236313 chr6:167360389 C/T cg20406979 chr6:167373233 NA 0.29 6.79 0.35 4.99e-11 Crohn's disease; LUSC cis rs12973672 0.812 rs10421096 chr19:35764559 C/T cg12095397 chr19:35769544 USF2 0.44 6.67 0.34 1.09e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs12637928 0.560 rs7611910 chr3:110183949 G/T cg17371621 chr15:61264283 RORA 0.36 6.08 0.32 3.3e-9 Neuroticism; LUSC cis rs9929218 0.817 rs3114404 chr16:68722096 C/T cg02972257 chr16:68554789 NA 0.44 5.67 0.3 3.14e-8 Colorectal cancer; LUSC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg07936489 chr17:37558343 FBXL20 -0.71 -10.03 -0.48 7.3e-21 Glomerular filtration rate (creatinine); LUSC cis rs11828289 0.607 rs78341320 chr11:23188865 C/T cg20040320 chr11:23191996 NA -0.58 -6.1 -0.32 2.95e-9 Cancer; LUSC cis rs9875589 0.509 rs6783645 chr3:14024542 T/C cg19554555 chr3:13937349 NA -0.39 -5.84 -0.3 1.25e-8 Ovarian reserve; LUSC cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg19875535 chr5:140030758 IK 0.47 7.57 0.38 3.6e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs7772486 0.902 rs1125462 chr6:146417832 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.58 -0.34 1.81e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs17685 0.753 rs1104879 chr7:75685568 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -8.03 -0.4 1.67e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg24209194 chr3:40518798 ZNF619 0.41 5.95 0.31 6.7e-9 Renal cell carcinoma; LUSC cis rs2933343 0.729 rs1680781 chr3:128612830 C/A cg11901034 chr3:128598214 ACAD9 -0.4 -6.24 -0.32 1.31e-9 IgG glycosylation; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.31 -5.79 -0.3 1.67e-8 Lymphocyte counts; LUSC cis rs1163251 0.837 rs658442 chr1:120244858 T/G cg19096424 chr1:120255104 PHGDH 0.44 6.03 0.31 4.29e-9 Blood metabolite levels; LUSC cis rs2439831 1.000 rs2584726 chr15:43715382 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.96 11.11 0.52 1.29e-24 Lung cancer in ever smokers; LUSC cis rs11209185 0.509 rs9326078 chr1:68452388 A/G cg22082780 chr1:68452167 NA 0.48 8.76 0.43 9.77e-17 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs7399018 0.739 rs7399073 chr12:51614050 C/A cg10377582 chr12:51612794 POU6F1 -0.34 -5.93 -0.31 7.52e-9 Cisplatin-induced ototoxicity; LUSC cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg05768032 chr16:30646687 NA 0.38 5.71 0.3 2.47e-8 Multiple myeloma; LUSC cis rs61931739 0.534 rs11052974 chr12:34029877 T/G cg06521331 chr12:34319734 NA -0.47 -7.68 -0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs11167764 1.000 rs11167764 chr5:141479065 A/C cg08523384 chr5:141488047 NDFIP1 -0.52 -7.48 -0.38 6.77e-13 Crohn's disease; LUSC cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg08807101 chr21:30365312 RNF160 -0.66 -10.1 -0.48 4.14e-21 Pancreatic cancer; LUSC cis rs9811920 0.809 rs793475 chr3:99543764 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.41 -6.01 -0.31 4.84e-9 Axial length; LUSC cis rs668210 0.894 rs1786171 chr11:65769809 G/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.59 8.23 0.41 4.16e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs11583043 0.874 rs6577219 chr1:101415707 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.89 0.35 2.76e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg11812906 chr14:75593930 NEK9 0.65 11.13 0.52 1.1e-24 Height; LUSC cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg03146154 chr1:46216737 IPP 0.56 8.12 0.41 9.17e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2677744 0.719 rs2106673 chr15:91452595 A/G cg23684204 chr15:91497937 RCCD1 0.39 5.7 0.3 2.69e-8 Attention deficit hyperactivity disorder; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg10296153 chr3:3168554 TRNT1 0.34 6.0 0.31 5.06e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 3.1e-34 Prudent dietary pattern; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg06877462 chr1:205807181 PM20D1 0.54 10.24 0.49 1.37e-21 Menarche (age at onset); LUSC cis rs4654899 0.758 rs1354792 chr1:21391875 C/T cg01072550 chr1:21505969 NA 0.54 8.6 0.43 3.2e-16 Superior frontal gyrus grey matter volume; LUSC cis rs1371867 0.846 rs1660346 chr8:101312497 A/G cg06002616 chr8:101225028 SPAG1 -0.46 -7.57 -0.38 3.77e-13 Atrioventricular conduction; LUSC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs600231 0.708 rs682845 chr11:65254201 A/G cg21890820 chr11:65308645 LTBP3 0.49 7.41 0.38 1.07e-12 Bone mineral density; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg17514098 chr12:125302114 SCARB1 -0.41 -6.77 -0.35 5.94e-11 N-glycan levels; LUSC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg09835421 chr16:68378352 PRMT7 -0.54 -6.15 -0.32 2.18e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1113500 0.897 rs10785832 chr1:108638899 G/A cg06207961 chr1:108661230 NA 0.41 7.64 0.39 2.27e-13 Growth-regulated protein alpha levels; LUSC trans rs6952808 0.594 rs3778969 chr7:2139990 A/G cg04565464 chr8:145669602 NFKBIL2 -0.37 -6.01 -0.31 4.8e-9 Bipolar disorder and schizophrenia; LUSC trans rs7824557 0.707 rs3808519 chr8:11142970 C/G cg08975724 chr8:8085496 FLJ10661 0.45 6.73 0.35 7.58e-11 Retinal vascular caliber; LUSC cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg13010199 chr12:38710504 ALG10B 0.67 10.38 0.49 4.53e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs4363385 0.747 rs1415959 chr1:152973690 C/T cg00922841 chr1:152955080 SPRR1A 0.45 7.99 0.4 2.15e-14 Inflammatory skin disease; LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.45 0.46 5.94e-19 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01687453 chr17:37026128 LASP1 -0.41 -6.09 -0.32 3.13e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6867913 0.709 rs891987 chr5:141467196 A/T cg23435118 chr5:141488016 NDFIP1 0.45 7.24 0.37 3.16e-12 Asthma; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg16325326 chr1:53192061 ZYG11B -0.81 -14.15 -0.61 5.95e-36 Monocyte count; LUSC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg21361702 chr7:150065534 REPIN1 0.47 6.26 0.32 1.16e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs4909189 1.000 rs62493650 chr7:158135570 G/T cg24154853 chr7:158122151 PTPRN2 0.35 5.81 0.3 1.49e-8 Response to amphetamines; LUSC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg04719120 chr6:96025338 MANEA 0.46 5.81 0.3 1.45e-8 Behavioural disinhibition (generation interaction); LUSC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg17971929 chr21:40555470 PSMG1 -0.64 -10.47 -0.5 2.19e-22 Cognitive function; LUSC cis rs6542838 0.673 rs1949424 chr2:99468341 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.41 5.66 0.3 3.18e-8 Fear of minor pain; LUSC trans rs9747201 0.962 rs6502062 chr17:80086177 T/G cg07393940 chr7:158741817 NA -0.54 -8.56 -0.42 4.27e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg12751644 chr20:60527061 NA -0.35 -6.07 -0.32 3.43e-9 Body mass index; LUSC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg00310523 chr12:86230176 RASSF9 0.47 8.62 0.43 2.74e-16 Major depressive disorder; LUSC cis rs7100689 0.622 rs10749569 chr10:82129892 G/A cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs9325144 0.560 rs10506127 chr12:39126686 C/G cg26384229 chr12:38710491 ALG10B -0.62 -10.3 -0.49 8.46e-22 Morning vs. evening chronotype; LUSC cis rs7527798 0.592 rs10863461 chr1:207840776 C/T cg09232269 chr1:207846808 CR1L -0.29 -6.33 -0.33 7.78e-10 Erythrocyte sedimentation rate; LUSC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg16206743 chr13:37633760 FAM48A 0.38 6.15 0.32 2.2e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.49 5.84 0.3 1.27e-8 Renal function-related traits (BUN); LUSC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg23758822 chr17:41437982 NA 1.0 18.97 0.72 5.5e-55 Menopause (age at onset); LUSC cis rs7267979 0.966 rs4815425 chr20:25398876 G/C cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2295359 1.000 rs2295359 chr1:67635950 G/A cg12940439 chr1:67600707 NA 0.35 5.86 0.31 1.12e-8 Psoriasis; LUSC cis rs2050392 0.624 rs303435 chr10:30731491 T/C cg18806716 chr10:30721971 MAP3K8 -0.71 -11.39 -0.53 1.31e-25 Inflammatory bowel disease; LUSC trans rs9929218 0.861 rs8056206 chr16:68802072 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -12.07 -0.55 4.41e-28 Colorectal cancer; LUSC cis rs7824557 0.815 rs2572430 chr8:11105304 G/T cg21775007 chr8:11205619 TDH 0.49 6.82 0.35 4.37e-11 Retinal vascular caliber; LUSC cis rs7719624 0.870 rs1990201 chr5:135395203 C/T cg12897067 chr5:135418308 NA -0.44 -6.4 -0.33 5.15e-10 Response to cytidine analogues (gemcitabine); LUSC cis rs7223966 1.000 rs11079508 chr17:61750066 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.74 0.35 6.99e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2303759 0.914 rs2288481 chr19:49878196 G/A cg22590775 chr19:49891494 CCDC155 0.61 8.06 0.4 1.37e-14 Multiple sclerosis; LUSC cis rs11785693 0.862 rs7009771 chr8:4990189 C/T cg26367366 chr8:4980734 NA 0.75 8.77 0.43 9.41e-17 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg01879757 chr17:41196368 BRCA1 -0.47 -7.16 -0.36 5.11e-12 Menopause (age at onset); LUSC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg00074818 chr8:8560427 CLDN23 0.58 9.87 0.48 2.57e-20 Obesity-related traits; LUSC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg26597838 chr10:835615 NA 0.78 9.16 0.45 5.21e-18 Eosinophil percentage of granulocytes; LUSC cis rs601339 1.000 rs35683065 chr12:123164062 G/C cg11919336 chr12:123188078 GPR109A 0.42 6.3 0.33 9.51e-10 Adiponectin levels; LUSC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg05855489 chr10:104503620 C10orf26 0.58 9.45 0.46 6.13e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3812831 0.695 rs7998546 chr13:114939914 C/G cg15896084 chr13:114927664 NA 0.37 6.72 0.35 7.87e-11 Schizophrenia; LUSC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.82 -0.39 6.81e-14 Blood metabolite levels; LUSC trans rs7726839 0.540 rs11750321 chr5:599196 C/T cg25482853 chr8:67687455 SGK3 1.12 15.85 0.66 1.36e-42 Obesity-related traits; LUSC cis rs7829975 0.846 rs11779061 chr8:8549432 G/A cg15556689 chr8:8085844 FLJ10661 -0.63 -9.74 -0.47 7.01e-20 Mood instability; LUSC cis rs2760061 0.505 rs708109 chr1:228190657 C/T cg02753203 chr1:228287806 NA 0.98 19.14 0.72 1.17e-55 Diastolic blood pressure; LUSC cis rs9300255 0.568 rs1627724 chr12:123638580 T/A cg05973401 chr12:123451056 ABCB9 0.54 6.64 0.34 1.24e-10 Neutrophil percentage of white cells; LUSC cis rs6690583 0.562 rs76839162 chr1:85530021 A/G cg11262906 chr1:85462892 MCOLN2 0.68 6.27 0.32 1.1e-9 Serum sulfate level; LUSC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg14552801 chr7:65878734 NA -0.46 -6.46 -0.33 3.72e-10 Aortic root size; LUSC cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg12310025 chr6:25882481 NA -0.35 -5.8 -0.3 1.57e-8 Height; LUSC cis rs2820315 0.838 rs2819347 chr1:201884288 C/G cg10061532 chr1:201886748 LMOD1 0.29 6.62 0.34 1.42e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.41 -0.42 1.23e-15 Height; LUSC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg27539214 chr16:67997921 SLC12A4 -0.59 -7.75 -0.39 1.11e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs10193935 0.901 rs1390609 chr2:42666230 G/T cg27598129 chr2:42591480 NA 0.57 7.86 0.4 5.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs4906332 1.000 rs7155822 chr14:103922390 A/G cg04998671 chr14:104000505 TRMT61A -0.46 -7.25 -0.37 2.94e-12 Coronary artery disease; LUSC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg06784218 chr1:46089804 CCDC17 0.55 10.78 0.51 1.85e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2658782 0.526 rs3020062 chr11:93061159 T/C cg15737290 chr11:93063684 CCDC67 0.87 13.37 0.59 6.07e-33 Pulmonary function decline; LUSC cis rs62400317 0.859 rs62436780 chr6:45128261 A/T cg18551225 chr6:44695536 NA -0.42 -6.84 -0.35 3.81e-11 Total body bone mineral density; LUSC cis rs1801251 1.000 rs283471 chr2:233656627 G/A cg25237894 chr2:233734115 C2orf82 0.36 6.15 0.32 2.27e-9 Coronary artery disease; LUSC cis rs968451 0.789 rs1569498 chr22:39714704 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.69 9.59 0.46 2.2e-19 Primary biliary cholangitis; LUSC cis rs763121 0.819 rs5757161 chr22:38990662 G/A cg06544989 chr22:39130855 UNC84B 0.36 6.45 0.33 3.98e-10 Menopause (age at onset); LUSC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg01652190 chr22:50026171 C22orf34 -0.31 -6.32 -0.33 8.35e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg08847533 chr14:75593920 NEK9 0.85 15.82 0.65 1.78e-42 Height; LUSC cis rs10089 0.953 rs4836359 chr5:127385518 T/A cg19767477 chr5:127420684 SLC12A2 -0.4 -5.74 -0.3 2.12e-8 Ileal carcinoids; LUSC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg00933542 chr6:150070202 PCMT1 0.33 6.91 0.35 2.48e-11 Lung cancer; LUSC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs7267979 0.966 rs2387885 chr20:25415224 G/A cg08601574 chr20:25228251 PYGB -0.43 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs61931739 0.534 rs1387789 chr12:34056304 C/A cg06521331 chr12:34319734 NA -0.51 -8.35 -0.42 1.85e-15 Morning vs. evening chronotype; LUSC cis rs10435719 0.780 rs9692662 chr8:11789863 C/T cg21775007 chr8:11205619 TDH 0.46 6.57 0.34 1.93e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs67072384 0.818 rs2291290 chr11:72465877 T/C cg04827223 chr11:72435913 ARAP1 -0.74 -6.42 -0.33 4.6e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs1448094 0.933 rs11836175 chr12:86311644 A/T cg00310523 chr12:86230176 RASSF9 0.41 7.22 0.37 3.47e-12 Major depressive disorder; LUSC cis rs6977660 0.714 rs12334001 chr7:19814399 T/C cg05791153 chr7:19748676 TWISTNB 0.7 7.45 0.38 8.29e-13 Thyroid stimulating hormone; LUSC cis rs8114671 0.967 rs6142321 chr20:33788474 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -5.93 -0.31 7.56e-9 Height; LUSC cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg16586182 chr3:47516702 SCAP -0.53 -7.5 -0.38 5.7e-13 Birth weight; LUSC cis rs6901250 0.569 rs686708 chr6:117091683 A/G cg12892004 chr6:117198278 RFX6 0.37 6.79 0.35 5.16e-11 C-reactive protein levels; LUSC cis rs11229555 0.609 rs4598685 chr11:58216864 A/G cg15696309 chr11:58395628 NA -0.65 -7.92 -0.4 3.67e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.18e-11 Developmental language disorder (linguistic errors); LUSC cis rs7615316 1.000 rs2049326 chr3:142337672 C/T cg16271453 chr3:142027066 XRN1 -0.36 -6.08 -0.32 3.26e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9902453 0.808 rs10445400 chr17:28183059 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.64 0.47 1.43e-19 Coffee consumption (cups per day); LUSC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg18654377 chr3:49208889 KLHDC8B -0.44 -5.88 -0.31 1.02e-8 Menarche (age at onset); LUSC cis rs4974559 0.895 rs10018133 chr4:1338246 C/T cg02980000 chr4:1222292 CTBP1 0.76 7.34 0.37 1.6e-12 Systolic blood pressure; LUSC cis rs7615316 1.000 rs2049325 chr3:142337430 A/G cg16271453 chr3:142027066 XRN1 -0.36 -6.08 -0.32 3.26e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7172677 1.000 rs4886422 chr15:75426723 C/T cg14664628 chr15:75095509 CSK -0.44 -5.81 -0.3 1.43e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.44 0.56 1.81e-29 Prudent dietary pattern; LUSC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg24675056 chr1:15929824 NA 0.48 8.27 0.41 3.15e-15 Systolic blood pressure; LUSC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg06634786 chr22:41940651 POLR3H 0.55 6.41 0.33 5.09e-10 Vitiligo; LUSC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg26441486 chr22:50317300 CRELD2 0.48 7.03 0.36 1.17e-11 Schizophrenia; LUSC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg00999904 chr2:3704751 ALLC -0.6 -9.24 -0.45 3.01e-18 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg25703541 chr22:24373054 LOC391322 -0.84 -14.37 -0.62 8.7e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs2980439 0.557 rs2976876 chr8:8318850 T/C cg21775007 chr8:11205619 TDH 0.42 6.02 0.31 4.66e-9 Neuroticism; LUSC cis rs8102476 0.640 rs7247241 chr19:38747272 T/C cg14131526 chr19:38747285 PPP1R14A -0.34 -5.98 -0.31 5.75e-9 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs7954584 0.583 rs10770186 chr12:122361412 A/G cg01765077 chr12:122356316 WDR66 0.49 6.73 0.35 7.26e-11 Mean corpuscular volume; LUSC cis rs7824557 0.564 rs13274106 chr8:11233958 A/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.73 -0.3 2.25e-8 Retinal vascular caliber; LUSC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg08847533 chr14:75593920 NEK9 -0.8 -14.71 -0.63 4.29e-38 Height; LUSC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26665246 chr5:179105570 CBY3 -0.4 -6.18 -0.32 1.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs68170813 0.652 rs76924513 chr7:107205887 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.48 -5.89 -0.31 9.58e-9 Coronary artery disease; LUSC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg15556689 chr8:8085844 FLJ10661 -0.64 -10.22 -0.49 1.6e-21 Mood instability; LUSC cis rs4776059 0.550 rs8036979 chr15:52947995 A/T cg22715398 chr15:52968154 KIAA1370 0.73 8.28 0.41 2.91e-15 Schizophrenia; LUSC cis rs9457247 0.624 rs17524252 chr6:167466978 T/G cg06454157 chr6:167490870 NA -0.3 -6.93 -0.35 2.21e-11 Crohn's disease; LUSC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg03690763 chr11:133734501 NA -0.33 -5.87 -0.31 1.07e-8 Childhood ear infection; LUSC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2219968 0.676 rs10156234 chr8:78835777 C/T cg00738934 chr8:78996279 NA -0.36 -6.09 -0.32 3.17e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2224391 0.628 rs2753237 chr6:5252675 A/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.5 -7.01 -0.36 1.31e-11 Height; LUSC cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg13535736 chr9:111863775 C9orf5 -0.39 -6.15 -0.32 2.19e-9 Menarche (age at onset); LUSC cis rs7312933 0.558 rs11181502 chr12:42823833 A/G cg01256987 chr12:42539512 GXYLT1 -0.4 -7.38 -0.37 1.3e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg05234568 chr11:5960015 NA 0.43 6.54 0.34 2.37e-10 DNA methylation (variation); LUSC cis rs35123781 1.000 rs589153 chr5:139057548 A/G cg10513866 chr5:139070639 NA 0.46 8.87 0.44 4.44e-17 Schizophrenia; LUSC cis rs11690935 0.632 rs6433323 chr2:172873060 A/G cg13550731 chr2:172543902 DYNC1I2 -0.58 -9.13 -0.45 6.87e-18 Schizophrenia; LUSC cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg11584989 chr19:19387371 SF4 0.6 7.31 0.37 1.93e-12 Bipolar disorder; LUSC cis rs3774830 0.714 rs73212742 chr4:5464915 A/G cg26943120 chr4:5472116 STK32B 0.29 5.77 0.3 1.84e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08726783 chr22:24199851 SLC2A11 -0.4 -5.96 -0.31 6.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg11645453 chr3:52864694 ITIH4 0.34 7.98 0.4 2.32e-14 Bipolar disorder; LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.04 0.36 1.09e-11 Platelet count; LUSC cis rs11690935 0.694 rs312921 chr2:172567225 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.78 -0.63 2.22e-38 Schizophrenia; LUSC cis rs12367572 0.663 rs1857926 chr12:45344524 C/T cg04608330 chr12:45269318 NELL2 -0.4 -6.18 -0.32 1.83e-9 Gut microbiome composition (summer); LUSC cis rs7927592 0.913 rs55883802 chr11:68278829 G/A cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.13e-9 Total body bone mineral density; LUSC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg21016266 chr12:122356598 WDR66 0.63 9.29 0.45 2.08e-18 Mean corpuscular volume; LUSC cis rs4499344 0.622 rs7246407 chr19:33061209 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.62 -7.89 -0.4 4.23e-14 Mean platelet volume; LUSC cis rs7178572 0.568 rs12913233 chr15:77543297 C/T cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.51e-14 Type 2 diabetes; LUSC cis rs61990749 0.597 rs28534379 chr14:78172140 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.4 -0.33 5.16e-10 Fibroblast growth factor basic levels; LUSC cis rs9814567 0.896 rs7653880 chr3:134345788 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.97 -0.61 2.98e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.58 0.38 3.49e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.87 0.35 3.19e-11 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Parkinson's disease; LUSC cis rs10392 0.543 rs16987679 chr20:37557185 G/C cg27552599 chr20:37590471 DHX35 0.46 7.35 0.37 1.57e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs2439831 0.850 rs2957637 chr15:43951118 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.9 9.62 0.47 1.66e-19 Lung cancer in ever smokers; LUSC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg11645453 chr3:52864694 ITIH4 0.33 7.57 0.38 3.67e-13 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.92e-10 Life satisfaction; LUSC cis rs17685 0.672 rs55807301 chr7:75807401 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 2.99e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -8.24 -0.41 3.99e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg21466736 chr12:48725269 NA -0.31 -5.83 -0.3 1.3e-8 Glycated hemoglobin levels; LUSC trans rs853679 0.546 rs200977 chr6:27854301 T/C cg01620082 chr3:125678407 NA -0.75 -7.11 -0.36 6.89e-12 Depression; LUSC cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg03146154 chr1:46216737 IPP 0.55 8.16 0.41 7.02e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs425277 0.958 rs262652 chr1:2090816 T/C cg03732007 chr1:2071316 PRKCZ 0.47 7.53 0.38 4.67e-13 Height; LUSC cis rs4566357 0.615 rs4675139 chr2:227908527 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.33 -0.41 2.13e-15 Coronary artery disease; LUSC cis rs17253792 0.915 rs78089630 chr14:56178584 G/C cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC trans rs11625034 1.000 rs11625034 chr14:54349976 A/G cg10394757 chr16:66879807 CA7 -0.24 -5.97 -0.31 6.17e-9 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs10771431 0.935 rs1988852 chr12:9372862 G/A cg27600084 chr12:12264075 NA 0.45 6.64 0.34 1.26e-10 Breast size; LUSC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg04414720 chr1:150670196 GOLPH3L 0.54 8.51 0.42 5.79e-16 Melanoma; LUSC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg13798780 chr7:105162888 PUS7 0.55 5.95 0.31 6.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7524258 0.868 rs7538921 chr1:7267007 T/C cg07173049 chr1:7289937 CAMTA1 0.35 7.2 0.37 3.89e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.49e-8 Breast cancer; LUSC trans rs800082 0.539 rs1178897 chr3:144241161 A/C cg24215973 chr2:240111563 HDAC4 -0.47 -7.27 -0.37 2.49e-12 Smoking behavior; LUSC cis rs4474465 0.790 rs7106931 chr11:78229612 A/G cg27205649 chr11:78285834 NARS2 0.53 6.06 0.31 3.69e-9 Alzheimer's disease (survival time); LUSC cis rs7615316 0.789 rs6440082 chr3:142114406 A/G cg16271453 chr3:142027066 XRN1 0.37 6.72 0.34 8.04e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg08999081 chr20:33150536 PIGU -0.54 -10.7 -0.51 3.69e-23 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg17366294 chr4:99064904 C4orf37 0.57 9.91 0.48 1.76e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1538970 1.000 rs11211101 chr1:45849311 C/G cg05343316 chr1:45956843 TESK2 0.59 8.46 0.42 8.79e-16 Platelet count; LUSC cis rs77633900 0.614 rs2468120 chr15:76909975 G/A cg21673338 chr15:77095150 SCAPER -0.72 -6.99 -0.36 1.48e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs4919687 0.550 rs7907503 chr10:104440050 C/T cg04362960 chr10:104952993 NT5C2 0.47 6.82 0.35 4.21e-11 Colorectal cancer; LUSC cis rs11674184 0.525 rs4669755 chr2:11748585 A/C cg07314298 chr2:11723111 GREB1 0.59 10.18 0.49 2.25e-21 Endometriosis; LUSC cis rs2115630 1.000 rs55646601 chr15:85323568 G/T cg09876464 chr15:85330779 ZNF592 0.36 6.69 0.34 9.51e-11 P wave terminal force; LUSC trans rs12579753 0.879 rs1987116 chr12:82156478 G/A cg07923666 chr12:49932857 KCNH3 -0.52 -6.74 -0.35 6.79e-11 Resting heart rate; LUSC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg21984481 chr17:79567631 NPLOC4 -0.59 -11.42 -0.53 1.03e-25 Eye color traits; LUSC cis rs3820928 0.874 rs13393902 chr2:227880554 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.8 -0.39 7.97e-14 Pulmonary function; LUSC cis rs3741151 0.773 rs73542952 chr11:73108556 A/G cg17517138 chr11:73019481 ARHGEF17 0.98 8.42 0.42 1.13e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs7824557 0.628 rs7008205 chr8:11197323 T/G cg06636001 chr8:8085503 FLJ10661 0.45 6.56 0.34 2.01e-10 Retinal vascular caliber; LUSC trans rs8072100 0.817 rs9892497 chr17:45545919 G/A cg03886242 chr7:26192032 NFE2L3 -0.42 -6.7 -0.34 9.01e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs734999 0.545 rs6698817 chr1:2564183 T/C cg18932078 chr1:2524107 MMEL1 -0.31 -6.89 -0.35 2.79e-11 Ulcerative colitis; LUSC cis rs3741151 0.686 rs11828904 chr11:73139116 T/C cg17517138 chr11:73019481 ARHGEF17 0.81 7.52 0.38 5.05e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.14e-9 Menopause (age at onset); LUSC cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 7.13 0.36 6.09e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.97e-10 Bipolar disorder; LUSC trans rs3808502 0.534 rs1529858 chr8:11145662 G/T cg15556689 chr8:8085844 FLJ10661 0.46 6.55 0.34 2.19e-10 Neuroticism; LUSC cis rs1577917 0.740 rs9344542 chr6:86393905 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.44 7.28 0.37 2.47e-12 Response to antipsychotic treatment; LUSC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.42 -6.15 -0.32 2.21e-9 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16469426 chr7:19748791 TWISTNB -0.46 -6.8 -0.35 4.79e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg16606324 chr3:10149918 C3orf24 0.64 9.23 0.45 3.29e-18 Alzheimer's disease; LUSC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg15664640 chr17:80829946 TBCD -0.75 -13.55 -0.6 1.26e-33 Breast cancer; LUSC cis rs7178572 0.568 rs4886515 chr15:77686886 G/A cg22256960 chr15:77711686 NA -0.5 -7.92 -0.4 3.57e-14 Type 2 diabetes; LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg14895029 chr7:2775587 GNA12 -0.37 -5.69 -0.3 2.8e-8 Height; LUSC cis rs9788682 0.947 rs7169584 chr15:78822660 A/T cg24631222 chr15:78858424 CHRNA5 0.84 11.39 0.53 1.35e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs56399783 0.901 rs12540539 chr7:2873294 C/T cg14895029 chr7:2775587 GNA12 0.5 6.0 0.31 5.02e-9 Childhood ear infection; LUSC cis rs981844 1.000 rs55792703 chr4:154668278 C/A cg14289246 chr4:154710475 SFRP2 0.48 6.1 0.32 2.87e-9 Response to statins (LDL cholesterol change); LUSC cis rs11997175 0.624 rs4733460 chr8:33675169 T/C ch.8.33884649F chr8:33765107 NA 0.47 7.07 0.36 9.32e-12 Body mass index; LUSC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg11871910 chr12:69753446 YEATS4 0.62 8.94 0.44 2.63e-17 Response to diuretic therapy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18454701 chr2:46844136 PIGF;CRIPT -0.42 -6.25 -0.32 1.22e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg01125463 chr6:42946178 PEX6 -0.35 -5.67 -0.3 3.06e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg18099408 chr3:52552593 STAB1 -0.4 -6.78 -0.35 5.35e-11 Bipolar disorder; LUSC cis rs7336332 0.941 rs9579097 chr13:28084337 C/T cg22138327 chr13:27999177 GTF3A 0.69 7.15 0.36 5.44e-12 Weight; LUSC cis rs11166629 0.651 rs7818130 chr8:135641806 G/A cg27224718 chr8:135614730 ZFAT 0.44 7.21 0.37 3.77e-12 Smoking quantity; LUSC cis rs1215050 0.755 rs811479 chr4:98727398 A/T cg05340658 chr4:99064831 C4orf37 0.44 6.91 0.35 2.39e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10979 0.571 rs7764231 chr6:143919151 C/G cg25407410 chr6:143891975 LOC285740 -0.57 -6.87 -0.35 3.17e-11 Hypospadias; LUSC cis rs1775715 0.737 rs1541260 chr10:32105570 C/T cg26784012 chr10:32216390 ARHGAP12 0.44 7.39 0.37 1.21e-12 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg16423285 chr20:60520624 NA -0.47 -5.9 -0.31 8.91e-9 Body mass index; LUSC cis rs4474742 1 rs4474742 chr17:28065578 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.54 -0.5 1.32e-22 Monocyte count; LUSC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.45 -8.26 -0.41 3.46e-15 Intelligence (multi-trait analysis); LUSC cis rs500891 0.525 rs12192277 chr6:84090641 G/C cg08257003 chr6:84140564 ME1 0.32 7.35 0.37 1.49e-12 Platelet-derived growth factor BB levels; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg09617296 chr13:100153694 TM9SF2 0.38 6.18 0.32 1.9e-9 Asthma; LUSC cis rs9815354 1.000 rs7646144 chr3:41853125 T/A cg03022575 chr3:42003672 ULK4 0.56 6.25 0.32 1.24e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg24642439 chr20:33292090 TP53INP2 0.47 7.24 0.37 3.04e-12 Glomerular filtration rate (creatinine); LUSC cis rs9341808 0.586 rs3805869 chr6:81045917 T/C cg08355045 chr6:80787529 NA 0.48 8.24 0.41 3.91e-15 Sitting height ratio; LUSC cis rs1670533 0.932 rs2248083 chr4:1052166 A/C cg02018176 chr4:1364513 KIAA1530 0.45 6.12 0.32 2.68e-9 Recombination rate (females); LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg12432903 chr7:1882776 MAD1L1 -0.51 -8.66 -0.43 2.06e-16 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.03 -0.4 1.68e-14 Chronic sinus infection; LUSC cis rs6977660 0.714 rs4721827 chr7:19825655 A/G cg05791153 chr7:19748676 TWISTNB 0.67 6.93 0.35 2.24e-11 Thyroid stimulating hormone; LUSC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg19729930 chr2:74357872 NA 0.92 17.85 0.7 1.56e-50 Gestational age at birth (maternal effect); LUSC cis rs1256061 0.654 rs1256033 chr14:64745399 A/G cg23250157 chr14:64679961 SYNE2 0.32 5.83 0.3 1.31e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs11677370 0.574 rs12329183 chr2:3866943 G/A cg17052675 chr2:3827356 NA -0.63 -9.62 -0.47 1.72e-19 Type 2 diabetes; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg07962043 chr11:60691582 TMEM132A 0.49 6.06 0.31 3.73e-9 Cognitive function;Information processing speed; LUSC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg06618935 chr21:46677482 NA -0.38 -7.54 -0.38 4.34e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4629710 0.592 rs11759793 chr6:131546384 G/A cg12700074 chr6:131571435 AKAP7 -0.36 -6.05 -0.31 3.92e-9 Multiple myeloma (IgH translocation); LUSC trans rs11098499 0.754 rs1849457 chr4:120254355 A/G cg25214090 chr10:38739885 LOC399744 0.43 6.51 0.34 2.73e-10 Corneal astigmatism; LUSC cis rs17604090 1.000 rs114892953 chr7:29676298 G/A cg19413766 chr7:29689036 LOC646762 -0.6 -6.77 -0.35 5.81e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg08798685 chr6:27730294 NA -0.64 -6.01 -0.31 4.93e-9 Breast cancer; LUSC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg00149659 chr3:10157352 C3orf10 1.01 14.42 0.62 5.3e-37 Alzheimer's disease; LUSC cis rs965604 1.000 rs1504549 chr15:78766629 C/T cg18825076 chr15:78729989 IREB2 -0.42 -6.82 -0.35 4.25e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.39 -0.33 5.54e-10 Extrinsic epigenetic age acceleration; LUSC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs8099014 1.000 rs8092062 chr18:56127875 C/T cg12907477 chr18:56117327 MIR122 0.44 6.99 0.36 1.52e-11 Platelet count; LUSC cis rs61931739 0.500 rs11053280 chr12:34559297 G/T cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.75 0.47 6.48e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7833986 0.501 rs2976036 chr8:57031721 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.12 0.55 2.99e-28 Height; LUSC cis rs6912958 0.677 rs111990232 chr6:88022240 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.39 7.04 0.36 1.11e-11 Monocyte percentage of white cells; LUSC trans rs61931739 0.517 rs11053067 chr12:34191391 T/C cg26384229 chr12:38710491 ALG10B 0.74 11.9 0.55 1.78e-27 Morning vs. evening chronotype; LUSC cis rs8062405 0.723 rs762633 chr16:28608341 T/C cg07382826 chr16:28625726 SULT1A1 0.29 6.19 0.32 1.73e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg14668632 chr7:2872130 GNA12 -0.45 -6.47 -0.33 3.53e-10 Height; LUSC trans rs6951245 0.872 rs112309216 chr7:1100296 A/T cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1712517 0.844 rs1163074 chr10:105021762 C/T cg05636881 chr10:105038444 INA 0.39 6.42 0.33 4.56e-10 Migraine; LUSC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.08e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4974559 0.947 rs28437782 chr4:1355062 A/G cg02980000 chr4:1222292 CTBP1 0.73 7.26 0.37 2.71e-12 Systolic blood pressure; LUSC cis rs9649213 0.614 rs4729432 chr7:97947055 G/C cg08684580 chr7:98029266 BAIAP2L1 0.38 5.82 0.3 1.35e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs11098499 0.866 rs9995136 chr4:120286845 A/G cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg13010199 chr12:38710504 ALG10B 0.64 9.82 0.47 3.8e-20 Bladder cancer; LUSC cis rs1018836 0.828 rs12548806 chr8:91564256 C/T cg16814680 chr8:91681699 NA -0.68 -10.91 -0.51 6.36e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs17407555 0.697 rs73212840 chr4:10087458 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -6.25 -0.32 1.26e-9 Schizophrenia (age at onset); LUSC cis rs58804349 0.685 rs11239855 chr10:43483879 A/G cg08461752 chr10:43522343 NA 0.58 7.15 0.36 5.43e-12 Pediatric bone mineral content (radius); LUSC cis rs12973672 0.812 rs12986033 chr19:35748782 A/G cg12095397 chr19:35769544 USF2 0.43 6.53 0.34 2.45e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7582720 1.000 rs72928608 chr2:203836507 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs12681288 0.823 rs4735974 chr8:1000218 T/G cg15309053 chr8:964076 NA 0.33 6.84 0.35 3.73e-11 Schizophrenia; LUSC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg09904177 chr6:26538194 HMGN4 0.42 6.19 0.32 1.74e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs8060686 0.516 rs7194894 chr16:68145062 C/T cg26727032 chr16:67993705 SLC12A4 -0.42 -5.79 -0.3 1.62e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg27535305 chr1:53392650 SCP2 0.36 6.82 0.35 4.3e-11 Monocyte count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05420251 chr10:102133820 C10orf75 -0.39 -5.94 -0.31 7.05e-9 Electrocardiographic conduction measures; LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg03354898 chr7:1950403 MAD1L1 -0.34 -6.7 -0.34 9.09e-11 Bipolar disorder and schizophrenia; LUSC cis rs4820294 0.770 rs7285699 chr22:38066556 A/C cg21798802 chr22:38057573 PDXP 0.35 7.22 0.37 3.45e-12 Fat distribution (HIV); LUSC trans rs6582630 0.519 rs11514056 chr12:38284001 G/T cg06521331 chr12:34319734 NA -0.41 -6.38 -0.33 5.95e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs12421382 0.614 rs12418763 chr11:109390360 C/T cg27471124 chr11:109292789 C11orf87 0.37 6.74 0.35 6.99e-11 Schizophrenia; LUSC cis rs9517320 0.534 rs4771306 chr13:99143661 T/C cg20487152 chr13:99095054 FARP1 -0.44 -7.9 -0.4 3.99e-14 Longevity; LUSC cis rs950776 0.518 rs8025429 chr15:78836362 G/A cg06917634 chr15:78832804 PSMA4 -0.81 -14.3 -0.62 1.58e-36 Sudden cardiac arrest; LUSC cis rs1062753 0.771 rs5751245 chr22:42620940 T/C cg00645731 chr22:42541494 CYP2D7P1 0.41 7.3 0.37 2.1e-12 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs9341835 0.772 rs9294202 chr6:64138954 A/G cg00787780 chr6:64151745 NA -0.33 -5.77 -0.3 1.82e-8 Schizophrenia; LUSC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg12463550 chr7:65579703 CRCP -0.51 -7.49 -0.38 6.15e-13 Aortic root size; LUSC trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.29 0.41 2.72e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs739496 0.542 rs7306529 chr12:111780644 A/G cg10833066 chr12:111807467 FAM109A 0.6 12.27 0.56 8.1e-29 Platelet count; LUSC cis rs8072100 0.840 rs56952963 chr17:45493826 T/C cg08085267 chr17:45401833 C17orf57 -0.54 -8.67 -0.43 1.94e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg03146154 chr1:46216737 IPP 0.57 8.47 0.42 8e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6546537 1.000 rs6546535 chr2:69833382 G/T cg10773587 chr2:69614142 GFPT1 -0.47 -7.34 -0.37 1.68e-12 Serum thyroid-stimulating hormone levels; LUSC cis rs478304 0.934 rs570954 chr11:65498261 A/G cg27068330 chr11:65405492 SIPA1 0.61 9.23 0.45 3.18e-18 Acne (severe); LUSC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.93 17.64 0.69 1.13e-49 Body mass index (adult); LUSC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg14895029 chr7:2775587 GNA12 -0.41 -6.11 -0.32 2.74e-9 Height; LUSC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg14456004 chr13:21872349 NA 1.02 14.26 0.62 2.38e-36 White matter hyperintensity burden; LUSC cis rs17270561 0.636 rs2070642 chr6:25831212 G/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.53 0.38 4.72e-13 Iron status biomarkers; LUSC cis rs9902453 0.967 rs11080121 chr17:28528842 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.44 0.42 9.61e-16 Coffee consumption (cups per day); LUSC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg12257692 chr3:49977190 RBM6 0.24 6.67 0.34 1.06e-10 Intelligence (multi-trait analysis); LUSC cis rs1878931 0.580 rs8062722 chr16:3409161 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.86 16.72 0.68 4.85e-46 Body mass index (adult); LUSC trans rs7538876 0.903 rs1324368 chr1:17752000 A/G cg13009662 chr5:127419527 SLC12A2;FLJ33630 0.42 6.11 0.32 2.83e-9 Basal cell carcinoma; LUSC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg06640241 chr16:89574553 SPG7 0.84 14.92 0.63 6.52e-39 Multiple myeloma (IgH translocation); LUSC cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg06784218 chr1:46089804 CCDC17 0.47 8.97 0.44 2.15e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg11764359 chr7:65958608 NA -0.78 -12.8 -0.57 8.35e-31 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01325958 chr17:37793326 STARD3 -0.39 -6.09 -0.32 3.17e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg18230493 chr5:56204884 C5orf35 -0.54 -8.66 -0.43 1.99e-16 Coronary artery disease; LUSC cis rs11195062 0.693 rs7912643 chr10:112027936 A/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -5.95 -0.31 6.69e-9 Multiple myeloma; LUSC cis rs72792276 1.000 rs10519971 chr5:127379216 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.81 -7.3 -0.37 2.06e-12 Red cell distribution width; LUSC cis rs10791097 0.739 rs12279359 chr11:130730544 G/A cg12179176 chr11:130786555 SNX19 0.73 11.94 0.55 1.37e-27 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs244293 0.931 rs244297 chr17:53241700 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.4 -5.8 -0.3 1.51e-8 Menarche (age at onset); LUSC cis rs11585357 1.000 rs11585357 chr1:17601165 C/T cg08277548 chr1:17600880 PADI3 -0.66 -6.98 -0.36 1.58e-11 Hair shape; LUSC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.64 0.63 7.44e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7264396 0.563 rs2425114 chr20:34322346 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.38 -0.42 1.49e-15 Total cholesterol levels; LUSC cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg20908204 chr19:46285434 DMPK -0.45 -8.46 -0.42 8.49e-16 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09770904 chr12:6309613 CD9 -0.4 -6.3 -0.33 9.23e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg06873352 chr17:61820015 STRADA 0.71 12.8 0.57 8.38e-31 Prudent dietary pattern; LUSC cis rs6906287 0.647 rs12197337 chr6:118884092 C/T cg21191810 chr6:118973309 C6orf204 0.33 6.05 0.31 3.83e-9 Electrocardiographic conduction measures; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00481081 chr10:74856747 P4HA1 -0.4 -5.97 -0.31 6.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6690583 1.000 rs6690583 chr1:85466337 A/G cg22153463 chr1:85462885 MCOLN2 -0.7 -8.81 -0.43 6.89e-17 Serum sulfate level; LUSC cis rs9796 0.561 rs7173086 chr15:41509288 A/T cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.56 -0.42 4.14e-16 Menopause (age at onset); LUSC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg19046167 chr17:80928561 B3GNTL1 -0.44 -6.33 -0.33 8.02e-10 Breast cancer; LUSC trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg15704280 chr7:45808275 SEPT13 -0.91 -13.64 -0.6 5.43e-34 Coronary artery disease; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg05564831 chr3:52568323 NT5DC2 0.36 6.72 0.35 7.78e-11 Electroencephalogram traits; LUSC cis rs12208915 0.848 rs12209635 chr6:79532215 C/T cg05283184 chr6:79620031 NA 0.43 5.8 0.3 1.52e-8 Left atrial antero-posterior diameter; LUSC cis rs911119 0.955 rs6036474 chr20:23604414 G/A cg16589663 chr20:23618590 CST3 0.59 7.07 0.36 9.31e-12 Chronic kidney disease; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg09177884 chr7:1199841 ZFAND2A -0.49 -6.66 -0.34 1.12e-10 Longevity;Endometriosis; LUSC cis rs7903847 0.620 rs17112676 chr10:99122288 G/A cg20016023 chr10:99160130 RRP12 -0.33 -7.98 -0.4 2.3e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs5753618 0.561 rs737684 chr22:31659827 C/G cg22777020 chr22:31556080 RNF185 -0.45 -5.76 -0.3 1.95e-8 Colorectal cancer; LUSC cis rs7100689 0.784 rs10749562 chr10:82108253 G/T cg01528321 chr10:82214614 TSPAN14 0.95 14.57 0.62 1.42e-37 Post bronchodilator FEV1; LUSC cis rs2580764 0.632 rs2588510 chr2:55199248 A/G cg20993754 chr2:55226987 RTN4 0.33 5.66 0.3 3.29e-8 Mean platelet volume; LUSC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg06108461 chr20:60628389 TAF4 -0.96 -15.13 -0.64 9.55e-40 Body mass index; LUSC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.37 -0.33 6.23e-10 Total body bone mineral density; LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.03 -0.68 3.06e-47 Gut microbiome composition (summer); LUSC cis rs6464929 0.910 rs12534095 chr7:148720705 C/T cg23583168 chr7:148888333 NA 0.46 5.86 0.31 1.09e-8 Pediatric bone mineral content (hip); LUSC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg06634786 chr22:41940651 POLR3H -0.52 -6.08 -0.32 3.25e-9 Vitiligo; LUSC cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg08085267 chr17:45401833 C17orf57 0.54 8.83 0.44 6.01e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs76878669 0.561 rs4930178 chr11:66129442 C/G cg18002602 chr11:66138449 SLC29A2 0.45 8.12 0.41 8.95e-15 Educational attainment (years of education); LUSC cis rs34779708 0.897 rs12764820 chr10:35386321 G/A cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg08200582 chr11:442649 ANO9 -0.53 -6.34 -0.33 7.31e-10 Body mass index; LUSC cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.36 -5.71 -0.3 2.54e-8 IgG glycosylation; LUSC cis rs6693567 0.565 rs1260398 chr1:150279876 T/C cg15654264 chr1:150340011 RPRD2 -0.45 -7.44 -0.38 8.64e-13 Migraine; LUSC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg09796270 chr17:17721594 SREBF1 0.4 7.05 0.36 1.06e-11 Total body bone mineral density; LUSC trans rs17685 0.753 rs13240404 chr7:75675719 C/T cg19862616 chr7:65841803 NCRNA00174 -1.14 -20.28 -0.74 3.45e-60 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.62 -0.34 1.46e-10 Lung cancer; LUSC cis rs6964587 1.000 rs6946356 chr7:91727385 G/A cg17063962 chr7:91808500 NA 0.59 9.25 0.45 2.65e-18 Breast cancer; LUSC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg08493051 chr2:3487164 NA -0.56 -8.6 -0.43 3.11e-16 Neurofibrillary tangles; LUSC cis rs7833986 0.534 rs2458083 chr8:56898785 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.68 10.93 0.51 5.61e-24 Height; LUSC cis rs2281845 0.533 rs10753891 chr1:201100482 A/G cg22815214 chr1:201083145 CACNA1S 0.44 6.83 0.35 4.04e-11 Permanent tooth development; LUSC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg06697600 chr4:7070879 GRPEL1 0.47 6.59 0.34 1.7e-10 Monocyte percentage of white cells; LUSC trans rs11098499 0.863 rs6534141 chr4:120485223 A/T cg25214090 chr10:38739885 LOC399744 0.52 7.7 0.39 1.51e-13 Corneal astigmatism; LUSC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg26513180 chr16:89883248 FANCA 0.88 17.29 0.69 2.74e-48 Vitiligo; LUSC trans rs6445525 0.967 rs2060022 chr3:65999755 A/G cg12639933 chr12:57626296 SHMT2 0.33 5.97 0.31 6.07e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1729407 0.709 rs2098453 chr11:116696680 C/T cg08985259 chr11:116699649 APOC3 -0.25 -5.83 -0.3 1.34e-8 Apolipoprotein A-IV levels; LUSC cis rs2235544 0.530 rs914720 chr1:54484482 C/T cg25741118 chr1:54482237 LDLRAD1 -0.33 -7.63 -0.39 2.51e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs231513 0.911 rs124722 chr17:41956002 T/G cg26893861 chr17:41843967 DUSP3 -0.5 -5.94 -0.31 7.03e-9 Cognitive function; LUSC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg05481257 chr2:20870211 GDF7 -0.37 -6.9 -0.35 2.59e-11 Abdominal aortic aneurysm; LUSC trans rs514406 1.000 rs514406 chr1:53330458 A/G cg24643429 chr1:3562429 WDR8 0.35 6.3 0.33 9.23e-10 Monocyte count; LUSC cis rs7746199 0.673 rs72845046 chr6:27575268 T/A cg26958806 chr6:27640298 NA 0.76 6.21 0.32 1.54e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs372883 0.580 rs2254038 chr21:30745722 C/T cg08807101 chr21:30365312 RNF160 0.66 10.35 0.49 5.88e-22 Pancreatic cancer; LUSC cis rs11690935 0.921 rs6710698 chr2:172596078 G/C cg13550731 chr2:172543902 DYNC1I2 -0.89 -14.98 -0.63 3.73e-39 Schizophrenia; LUSC cis rs12369635 1.000 rs9645723 chr12:129554501 C/T cg01909103 chr12:129572610 TMEM132D -0.62 -5.93 -0.31 7.4e-9 Schizophrenia (inflammation and infection response interaction); LUSC cis rs2235544 0.565 rs637590 chr1:54461703 A/G cg25741118 chr1:54482237 LDLRAD1 0.29 6.49 0.33 3.14e-10 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs208520 0.802 rs4710314 chr6:66883656 G/A cg07460842 chr6:66804631 NA -1.05 -15.66 -0.65 7.51e-42 Exhaled nitric oxide output; LUSC cis rs8016982 0.674 rs61980899 chr14:81676844 T/C cg01989461 chr14:81687754 GTF2A1 0.72 12.73 0.57 1.6e-30 Schizophrenia; LUSC cis rs1559088 1.000 rs28840147 chr19:33561976 A/G cg27124370 chr19:33622961 WDR88 0.53 6.69 0.34 9.21e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15266121 chr12:105630063 APPL2 -0.4 -6.26 -0.32 1.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.48 5.81 0.3 1.49e-8 Renal function-related traits (BUN); LUSC cis rs4919694 0.572 rs4917995 chr10:104845443 A/T cg05855489 chr10:104503620 C10orf26 -0.58 -6.79 -0.35 5.26e-11 Arsenic metabolism; LUSC trans rs35110281 0.840 rs7276633 chr21:45078800 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.53 0.46 3.4e-19 Mean corpuscular volume; LUSC cis rs2292884 0.505 rs78063959 chr2:238428961 G/A cg14458575 chr2:238380390 NA 0.46 5.76 0.3 1.95e-8 Prostate cancer; LUSC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs870825 0.616 rs12512839 chr4:185610347 G/A cg04058563 chr4:185651563 MLF1IP 0.86 12.83 0.57 6.41e-31 Blood protein levels; LUSC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg16850897 chr7:100343110 ZAN -0.46 -5.87 -0.31 1.05e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg24813613 chr7:1882135 MAD1L1 -0.45 -7.62 -0.38 2.71e-13 Bipolar disorder and schizophrenia; LUSC cis rs9467773 1.000 rs9393732 chr6:26530898 G/A cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.88e-18 Intelligence (multi-trait analysis); LUSC trans rs12210905 1.000 rs5030958 chr6:27214257 G/C cg11837749 chr1:55047332 ACOT11 0.58 6.19 0.32 1.76e-9 Hip circumference adjusted for BMI; LUSC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.0 0.31 5.23e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs595982 0.559 rs17272680 chr19:49364511 A/G cg15549821 chr19:49342101 PLEKHA4 0.56 7.78 0.39 9.33e-14 Red cell distribution width; LUSC cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg05347473 chr6:146136440 FBXO30 0.52 8.67 0.43 1.95e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs1055129 0.560 rs2305913 chr17:73922941 T/C cg08125733 chr17:73851984 WBP2 0.47 6.56 0.34 2.04e-10 White matter hyperintensity burden; LUSC cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC cis rs950776 0.518 rs12915428 chr15:78823368 G/A cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC trans rs1459104 0.866 rs28822225 chr11:54818606 C/G cg03929089 chr4:120376271 NA 0.7 6.06 0.31 3.72e-9 Body mass index; LUSC cis rs17685 0.725 rs6947068 chr7:75662056 T/C cg16489192 chr7:75678113 MDH2;STYXL1 0.52 7.99 0.4 2.24e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg21433313 chr16:3507492 NAT15 0.41 5.77 0.3 1.76e-8 Body mass index (adult); LUSC cis rs6500602 0.964 rs62039173 chr16:4463846 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.46 5.79 0.3 1.61e-8 Schizophrenia; LUSC cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.22 0.52 5.24e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg24733560 chr20:60626293 TAF4 0.43 6.92 0.35 2.25e-11 Body mass index; LUSC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg03388025 chr16:89894329 SPIRE2 0.3 6.31 0.33 8.74e-10 Vitiligo; LUSC cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg08807101 chr21:30365312 RNF160 0.79 14.9 0.63 7.6e-39 Dental caries; LUSC cis rs7804356 1.000 rs12535784 chr7:26882067 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.67e-9 Type 1 diabetes; LUSC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg26587870 chr6:27730563 NA -0.66 -5.98 -0.31 5.62e-9 Depression; LUSC cis rs9814567 1.000 rs1863913 chr3:134200205 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.12 -0.58 5.09e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1595825 0.838 rs73058854 chr2:198885060 G/A cg10547527 chr2:198650123 BOLL -0.53 -6.36 -0.33 6.65e-10 Ulcerative colitis; LUSC cis rs1008375 0.966 rs3796812 chr4:17582051 G/A cg18681998 chr4:17616180 MED28 0.81 14.81 0.63 1.74e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg08847533 chr14:75593920 NEK9 0.85 15.77 0.65 2.82e-42 Height; LUSC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.54e-9 Intelligence (multi-trait analysis); LUSC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg09165964 chr15:75287851 SCAMP5 0.45 6.78 0.35 5.33e-11 Breast cancer; LUSC cis rs3740713 1.000 rs73440625 chr11:18470800 A/G cg07915343 chr11:18477680 LDHAL6A -0.54 -6.74 -0.35 6.85e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs151234 0.741 rs151227 chr16:28549508 C/T cg01378222 chr16:28622494 SULT1A1 -0.56 -8.26 -0.41 3.53e-15 Platelet distribution width; LUSC cis rs12579753 0.917 rs7306043 chr12:82191282 G/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs17685 0.753 rs10233282 chr7:75790081 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg21782813 chr7:2030301 MAD1L1 0.52 9.11 0.45 7.51e-18 Bipolar disorder and schizophrenia; LUSC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg09165964 chr15:75287851 SCAMP5 0.45 6.71 0.34 8.36e-11 Breast cancer; LUSC trans rs796395 0.664 rs2993047 chr1:218685055 G/A cg05473648 chr11:79113178 MIR708;ODZ4 -0.34 -5.98 -0.31 5.64e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs921968 0.608 rs495855 chr2:219357858 A/G cg02176678 chr2:219576539 TTLL4 0.6 10.67 0.5 4.48e-23 Mean corpuscular hemoglobin concentration; LUSC trans rs7826238 0.535 rs2979179 chr8:8320029 C/T cg21775007 chr8:11205619 TDH 0.42 6.2 0.32 1.66e-9 Systolic blood pressure; LUSC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg17143192 chr8:8559678 CLDN23 0.65 9.4 0.46 9.2e-19 Obesity-related traits; LUSC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg14583973 chr4:3374767 RGS12 0.29 6.31 0.33 8.66e-10 Parental longevity (mother's age at death); LUSC cis rs2273669 0.667 rs12198088 chr6:109338433 C/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 8.89e-9 Prostate cancer; LUSC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.01e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.25 -0.52 4e-25 Mean corpuscular volume; LUSC cis rs12594515 0.506 rs74199860 chr15:45989190 C/T cg19682013 chr15:45996608 NA 0.39 6.0 0.31 5.15e-9 Waist circumference;Weight; LUSC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs4964805 0.657 rs11111787 chr12:104189499 C/T cg02344784 chr12:104178138 NT5DC3 0.46 8.86 0.44 4.8e-17 Attention deficit hyperactivity disorder; LUSC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.62 -0.34 1.42e-10 Lung cancer; LUSC cis rs908922 0.651 rs548252 chr1:152489742 A/G cg20991723 chr1:152506922 NA -0.54 -10.18 -0.49 2.29e-21 Hair morphology; LUSC cis rs826838 1.000 rs7299124 chr12:39002661 T/C cg13010199 chr12:38710504 ALG10B 0.69 11.52 0.53 4.54e-26 Heart rate; LUSC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg14895029 chr7:2775587 GNA12 -0.46 -7.02 -0.36 1.22e-11 Height; LUSC cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg26384229 chr12:38710491 ALG10B 0.87 14.56 0.62 1.53e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg24733560 chr20:60626293 TAF4 0.37 6.11 0.32 2.83e-9 Body mass index; LUSC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.46 7.93 0.4 3.4e-14 Total body bone mineral density; LUSC cis rs6977660 0.714 rs12672320 chr7:19813594 G/T cg05791153 chr7:19748676 TWISTNB 0.7 7.47 0.38 7.16e-13 Thyroid stimulating hormone; LUSC cis rs877282 1.000 rs71494928 chr10:769134 A/G cg17470449 chr10:769945 NA 0.55 7.82 0.39 7.21e-14 Uric acid levels; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg18402987 chr7:1209562 NA 0.69 7.41 0.38 1.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2073300 1.000 rs6132623 chr20:23442324 T/A cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.88 -0.51 8.12e-24 Schizophrenia; LUSC cis rs2075371 0.501 rs1646653 chr7:134024686 A/G cg20476274 chr7:133979776 SLC35B4 0.74 12.45 0.56 1.67e-29 Mean platelet volume; LUSC cis rs2816062 0.813 rs2745321 chr1:18889198 G/C cg18795169 chr1:18902165 NA -0.97 -22.1 -0.77 2.49e-67 Urate levels in lean individuals; LUSC cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs9486719 0.656 rs4839826 chr6:96853616 A/G cg06623918 chr6:96969491 KIAA0776 -0.75 -10.57 -0.5 1e-22 Migraine;Coronary artery disease; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg05552183 chr6:42928497 GNMT 0.47 7.66 0.39 1.99e-13 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13076329 chr4:114682704 CAMK2D -0.43 -5.96 -0.31 6.35e-9 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.61 -0.6 7.34e-34 Chronic sinus infection; LUSC cis rs2439831 0.867 rs12443102 chr15:43932103 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 9.49 0.46 4.4e-19 Lung cancer in ever smokers; LUSC cis rs73206853 0.841 rs73191851 chr12:111032305 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.54 0.34 2.3e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg04362960 chr10:104952993 NT5C2 0.58 9.18 0.45 4.58e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -8.71 -0.43 1.45e-16 Hemoglobin concentration; LUSC cis rs4891159 0.548 rs690414 chr18:74117840 T/C cg24786174 chr18:74118243 ZNF516 0.97 21.55 0.76 3.54e-65 Longevity; LUSC cis rs9747201 0.926 rs8065606 chr17:80063526 G/A cg18209359 chr17:80159595 CCDC57 0.36 5.68 0.3 2.95e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs60154123 0.614 rs645890 chr1:210459801 A/C cg22029157 chr1:209979665 IRF6 0.52 5.94 0.31 6.96e-9 Coronary artery disease; LUSC cis rs9309473 0.606 rs79234109 chr2:73848354 G/A cg20560298 chr2:73613845 ALMS1 -0.5 -5.79 -0.3 1.59e-8 Metabolite levels; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg05368731 chr17:41323189 NBR1 0.93 15.66 0.65 7.69e-42 Menopause (age at onset); LUSC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg08684580 chr7:98029266 BAIAP2L1 0.42 7.82 0.39 6.83e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7617480 0.558 rs12715430 chr3:48942855 A/C cg21141812 chr3:48556323 PFKFB4 0.33 5.85 0.3 1.19e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg08888203 chr3:10149979 C3orf24 0.48 7.06 0.36 9.82e-12 Alzheimer's disease; LUSC cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg19717773 chr7:2847554 GNA12 -0.4 -7.22 -0.37 3.5e-12 Plateletcrit; LUSC cis rs76878669 0.561 rs7107191 chr11:66140397 G/A cg24851651 chr11:66362959 CCS -0.36 -5.68 -0.3 3.01e-8 Educational attainment (years of education); LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.59 -9.32 -0.45 1.58e-18 Lymphocyte counts; LUSC cis rs1957429 0.808 rs4902325 chr14:65330843 A/G cg23373153 chr14:65346875 NA -0.94 -10.53 -0.5 1.46e-22 Pediatric areal bone mineral density (radius); LUSC cis rs7903847 0.642 rs11189191 chr10:99148796 T/C cg08345082 chr10:99160200 RRP12 -0.37 -7.11 -0.36 6.88e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7909074 0.966 rs4245614 chr10:45397007 C/T cg04218760 chr10:45406644 TMEM72 -0.29 -6.9 -0.35 2.6e-11 Mean corpuscular volume; LUSC cis rs2227631 0.505 rs12530730 chr7:100758591 T/A cg18465962 chr7:100767262 NA 0.39 6.25 0.32 1.26e-9 Plasminogen activator inhibitor type 1 levels (PAI-1); LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg14004847 chr7:1930337 MAD1L1 -0.52 -8.07 -0.4 1.28e-14 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs765787 0.530 rs2554454 chr15:45521536 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -8.06 -0.4 1.4e-14 Uric acid levels; LUSC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg03526776 chr6:41159608 TREML2 -0.32 -6.12 -0.32 2.59e-9 Alzheimer's disease (late onset); LUSC cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg18681998 chr4:17616180 MED28 0.86 15.82 0.65 1.84e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3092073 0.617 rs17448680 chr20:44594726 T/C cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.38 -5.95 -0.31 6.94e-9 Intelligence (multi-trait analysis); LUSC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg11843238 chr5:131593191 PDLIM4 -0.37 -6.03 -0.31 4.26e-9 Breast cancer; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg15147215 chr3:52552868 STAB1 0.32 6.54 0.34 2.26e-10 Electroencephalogram traits; LUSC cis rs4343996 0.870 rs4722708 chr7:3382563 A/T cg21248987 chr7:3385318 SDK1 -0.4 -6.86 -0.35 3.25e-11 Motion sickness; LUSC cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg20295408 chr7:1910781 MAD1L1 -0.48 -6.86 -0.35 3.37e-11 Bipolar disorder and schizophrenia; LUSC cis rs4363385 0.747 rs6671524 chr1:152974247 C/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.78 -0.39 9.11e-14 Inflammatory skin disease; LUSC cis rs6840360 0.615 rs12647465 chr4:152607318 C/A cg22705602 chr4:152727874 NA -0.36 -7.61 -0.38 2.79e-13 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.57e-10 Lung cancer; LUSC cis rs11098499 0.657 rs9996569 chr4:120299004 G/C cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC trans rs61931739 0.817 rs1705772 chr12:34174756 G/A cg26384229 chr12:38710491 ALG10B 0.55 8.8 0.43 7.24e-17 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26434548 chr7:129074607 FAM40B -0.46 -6.06 -0.31 3.61e-9 Bipolar disorder and schizophrenia; LUSC cis rs7188861 0.813 rs12596260 chr16:11398265 T/G cg00044050 chr16:11439710 C16orf75 0.55 6.15 0.32 2.21e-9 HDL cholesterol; LUSC cis rs7223966 1.000 rs11870797 chr17:61804622 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.92 0.35 2.31e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4595586 0.545 rs2197940 chr12:39401937 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.99 0.31 5.41e-9 Morning vs. evening chronotype; LUSC cis rs1878931 0.697 rs10048148 chr16:3417450 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 16.71 0.67 5.51e-46 Body mass index (adult); LUSC trans rs2282526 0.615 rs162377 chr21:44926001 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.12 0.41 9.4e-15 Mean corpuscular hemoglobin; LUSC cis rs2760061 0.583 rs708118 chr1:228201801 A/G cg20976159 chr1:228193529 WNT3A -0.31 -6.19 -0.32 1.79e-9 Diastolic blood pressure; LUSC cis rs8092503 1.000 rs8085272 chr18:52481583 A/G cg12377874 chr18:52495404 RAB27B -0.32 -5.72 -0.3 2.31e-8 Childhood body mass index; LUSC cis rs3540 0.618 rs11609 chr15:91043765 C/G cg10434728 chr15:90938212 IQGAP1 -0.46 -9.23 -0.45 3.16e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs8073060 0.927 rs7502331 chr17:33868858 A/G cg19694781 chr19:47549865 TMEM160 0.69 10.55 0.5 1.2e-22 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg21573476 chr21:45109991 RRP1B -0.41 -6.74 -0.35 7.09e-11 Mean corpuscular volume; LUSC cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg00631329 chr6:26305371 NA -0.45 -8.86 -0.44 4.68e-17 Educational attainment; LUSC cis rs1595825 0.732 rs7577835 chr2:198378056 T/C cg00982548 chr2:198649783 BOLL -0.51 -6.19 -0.32 1.72e-9 Ulcerative colitis; LUSC cis rs11605275 1.000 rs11605704 chr11:20032096 A/G cg14835545 chr11:20032148 NAV2 0.86 6.61 0.34 1.54e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7539409 0.651 rs6576953 chr1:84316946 A/G cg10977910 chr1:84465055 TTLL7 0.75 7.93 0.4 3.38e-14 Alzheimer's disease; LUSC cis rs2204008 0.617 rs11831608 chr12:38210687 C/T cg26384229 chr12:38710491 ALG10B -0.68 -10.31 -0.49 7.72e-22 Bladder cancer; LUSC cis rs12472274 0.817 rs12621791 chr2:239104061 G/A cg17459225 chr2:239074497 NA 0.63 9.96 0.48 1.24e-20 Phospholipid levels (plasma); LUSC cis rs782590 0.837 rs809732 chr2:55914621 T/C cg18811423 chr2:55921094 PNPT1 0.9 16.03 0.66 2.76e-43 Metabolic syndrome; LUSC cis rs11997175 0.624 rs7016783 chr8:33696831 A/G ch.8.33884649F chr8:33765107 NA 0.45 6.77 0.35 5.67e-11 Body mass index; LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg04267008 chr7:1944627 MAD1L1 -0.47 -7.02 -0.36 1.24e-11 Bipolar disorder and schizophrenia; LUSC cis rs9486715 0.867 rs6568428 chr6:96903604 A/G cg06623918 chr6:96969491 KIAA0776 0.94 17.45 0.69 6.2e-49 Headache; LUSC cis rs9303401 0.703 rs9910629 chr17:57210301 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.53 8.12 0.41 9.31e-15 Cognitive test performance; LUSC cis rs7582720 1.000 rs72934556 chr2:203990789 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.84 8.71 0.43 1.44e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1595825 0.836 rs79748557 chr2:198567912 G/T cg00982548 chr2:198649783 BOLL -0.55 -7.01 -0.36 1.31e-11 Ulcerative colitis; LUSC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg09417038 chr21:47716443 C21orf57 0.43 6.92 0.35 2.37e-11 Testicular germ cell tumor; LUSC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg00031303 chr3:195681400 NA 0.68 9.77 0.47 5.42e-20 Pancreatic cancer; LUSC trans rs7829975 0.688 rs7826660 chr8:8379107 C/A cg27411982 chr8:10470053 RP1L1 0.45 7.51 0.38 5.53e-13 Mood instability; LUSC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg07936489 chr17:37558343 FBXL20 -0.66 -8.99 -0.44 1.88e-17 Glomerular filtration rate (creatinine); LUSC cis rs11105298 0.891 rs11105319 chr12:89927177 G/A cg00757033 chr12:89920650 WDR51B 0.61 10.24 0.49 1.39e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg04944784 chr2:26401820 FAM59B -0.7 -9.79 -0.47 4.49e-20 Gut microbiome composition (summer); LUSC cis rs2303282 0.664 rs899242 chr16:56398585 C/G cg00500540 chr16:56394104 NA -0.4 -6.96 -0.36 1.76e-11 Breast cancer; LUSC cis rs16917546 1.000 rs10995260 chr10:64410580 G/A cg03961010 chr10:64397487 ZNF365 -0.43 -6.77 -0.35 5.63e-11 Basal cell carcinoma; LUSC cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg18132916 chr6:79620363 NA -0.38 -5.74 -0.3 2.18e-8 Intelligence (multi-trait analysis); LUSC cis rs34375054 0.558 rs67041765 chr12:125672913 T/G cg00522288 chr12:125625016 AACS -0.35 -6.45 -0.33 3.9e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg18252515 chr7:66147081 NA 1.24 14.21 0.61 3.56e-36 Diabetic kidney disease; LUSC cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.7 0.39 1.51e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg01065977 chr19:18549689 ISYNA1 -0.24 -6.01 -0.31 4.94e-9 Breast cancer; LUSC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg24733560 chr20:60626293 TAF4 0.38 6.31 0.33 8.74e-10 Body mass index; LUSC cis rs1322512 1.000 rs2250632 chr6:153011126 C/A cg03415253 chr6:152958462 SYNE1 0.38 5.68 0.3 2.95e-8 Tonometry; LUSC trans rs6089829 0.962 rs6011544 chr20:61658782 T/C cg15934090 chr1:100435551 SLC35A3 0.47 7.72 0.39 1.4e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs34779708 0.931 rs67261877 chr10:35386340 T/A cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10761482 0.813 rs10821727 chr10:62099113 C/T cg18175470 chr10:62150864 ANK3 -0.51 -7.36 -0.37 1.48e-12 Schizophrenia; LUSC cis rs9462027 0.628 rs3734268 chr6:34716028 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.9 -0.31 9.02e-9 Systemic lupus erythematosus; LUSC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg11494091 chr17:61959527 GH2 0.39 6.77 0.35 5.68e-11 Height; LUSC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.6 -5.66 -0.3 3.24e-8 Cerebrospinal P-tau181p levels; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg18883852 chr13:45965548 LOC100190939 -0.39 -6.3 -0.33 9.4e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC trans rs877282 1.000 rs12775643 chr10:773242 G/A cg22713356 chr15:30763199 NA 1.08 15.38 0.64 9.93e-41 Uric acid levels; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.93 -0.51 5.65e-24 Alzheimer's disease; LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs921968 0.565 rs6761437 chr2:219598092 G/A cg02176678 chr2:219576539 TTLL4 -0.57 -9.99 -0.48 1.02e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs6460942 0.915 rs2216051 chr7:12304054 G/A cg06484146 chr7:12443880 VWDE -0.52 -6.29 -0.33 9.98e-10 Coronary artery disease; LUSC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg12365402 chr11:9010492 NRIP3 -0.42 -7.55 -0.38 4.2e-13 Hemoglobin concentration; LUSC cis rs10266483 0.739 rs12665990 chr7:63865000 G/A cg24201672 chr7:64023550 ZNF680 0.5 6.03 0.31 4.28e-9 Response to statin therapy; LUSC cis rs6964587 0.610 rs6465338 chr7:91450624 T/C cg17063962 chr7:91808500 NA 0.53 8.62 0.43 2.73e-16 Breast cancer; LUSC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.57 0.34 1.88e-10 Menarche (age at onset); LUSC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg05623727 chr3:50126028 RBM5 -0.35 -6.65 -0.34 1.21e-10 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg25767906 chr1:53392781 SCP2 -0.48 -8.6 -0.43 3.12e-16 Monocyte count; LUSC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.15 0.49 2.9e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9309473 0.607 rs7573719 chr2:73582986 G/A cg20560298 chr2:73613845 ALMS1 -0.57 -8.3 -0.41 2.62e-15 Metabolite levels; LUSC cis rs16854884 0.657 rs12107291 chr3:143739547 T/C cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs708547 0.830 rs1713994 chr4:57868367 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -6.99 -0.36 1.47e-11 Response to bleomycin (chromatid breaks); LUSC cis rs3772130 1.000 rs3772130 chr3:121344140 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.66 9.47 0.46 5.11e-19 Cognitive performance; LUSC cis rs921968 0.541 rs933994 chr2:219650616 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.22 -0.49 1.59e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg16145915 chr7:1198662 ZFAND2A -0.49 -9.12 -0.45 7.36e-18 Longevity;Endometriosis; LUSC cis rs1670533 0.932 rs6599276 chr4:1056827 T/C cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg11941060 chr3:133502564 NA -0.52 -7.96 -0.4 2.68e-14 Iron status biomarkers; LUSC cis rs6977660 0.714 rs12700075 chr7:19791476 G/T cg07541023 chr7:19748670 TWISTNB 0.67 7.09 0.36 8.25e-12 Thyroid stimulating hormone; LUSC cis rs5758511 0.680 rs56111723 chr22:42664883 T/A cg00645731 chr22:42541494 CYP2D7P1 0.55 9.7 0.47 9.47e-20 Birth weight; LUSC cis rs9356171 0.572 rs62435477 chr6:164328670 C/T cg25752492 chr6:164341247 NA -0.39 -6.58 -0.34 1.79e-10 Diisocyanate-induced asthma; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs6138458 1.000 rs227621 chr20:24910528 A/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.94 -0.36 2.02e-11 Blood protein levels; LUSC trans rs7681440 0.904 rs7680761 chr4:90763510 A/T cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.01 -0.31 4.92e-9 Dementia with Lewy bodies; LUSC cis rs7980687 0.657 rs2851447 chr12:123665113 G/C cg00376283 chr12:123451042 ABCB9 0.69 9.71 0.47 8.23e-20 Height;Educational attainment;Head circumference (infant); LUSC cis rs864537 0.676 rs1773560 chr1:167421763 A/G cg22356347 chr1:167427500 CD247 -0.29 -6.61 -0.34 1.54e-10 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 6.86 0.35 3.25e-11 Platelet count; LUSC cis rs1577917 0.958 rs1816937 chr6:86557251 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg01884057 chr2:25150051 NA 0.48 11.26 0.52 3.91e-25 Body mass index; LUSC cis rs977987 0.836 rs7198873 chr16:75474754 G/A cg03315344 chr16:75512273 CHST6 0.49 9.31 0.45 1.73e-18 Dupuytren's disease; LUSC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg25072359 chr17:41440525 NA 0.62 9.07 0.44 1.05e-17 Menopause (age at onset); LUSC cis rs10886558 0.630 rs4237512 chr10:121810127 A/C cg02041677 chr10:121771263 NA -0.33 -6.35 -0.33 7.16e-10 Shingles; LUSC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg19717773 chr7:2847554 GNA12 0.43 6.72 0.35 7.81e-11 Height; LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.49 6.14 0.32 2.31e-9 Schizophrenia; LUSC cis rs12048904 0.964 rs17123467 chr1:101331760 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.51 8.0 0.4 2.03e-14 Multiple sclerosis; LUSC cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg00409905 chr10:38381863 ZNF37A -0.36 -6.17 -0.32 1.98e-9 Extrinsic epigenetic age acceleration; LUSC cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg25173405 chr17:45401733 C17orf57 0.36 5.76 0.3 1.96e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs847577 0.748 rs940431 chr7:97716495 C/T cg21770322 chr7:97807741 LMTK2 0.5 8.59 0.43 3.5e-16 Breast cancer; LUSC cis rs6690583 0.623 rs12042018 chr1:85436937 T/C cg11262906 chr1:85462892 MCOLN2 0.68 6.61 0.34 1.55e-10 Serum sulfate level; LUSC cis rs6930083 0.737 rs13196885 chr6:36632688 C/T cg08179530 chr6:36648295 CDKN1A -0.49 -6.67 -0.34 1.05e-10 Coronary artery disease; LUSC cis rs9300255 0.722 rs1060105 chr12:123806219 C/T cg00376283 chr12:123451042 ABCB9 -0.71 -8.08 -0.4 1.17e-14 Neutrophil percentage of white cells; LUSC cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs72772090 1.000 rs56116814 chr5:96048714 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.62 -6.91 -0.35 2.39e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6495367 0.803 rs2870111 chr15:79403585 C/T cg17916960 chr15:79447300 NA 0.4 7.45 0.38 8.2e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs79976124 0.800 rs10944857 chr6:66637078 C/T cg07460842 chr6:66804631 NA 0.7 8.69 0.43 1.68e-16 Type 2 diabetes; LUSC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg09455208 chr3:40491958 NA 0.53 9.47 0.46 5.15e-19 Renal cell carcinoma; LUSC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 0.39 6.01 0.31 4.93e-9 Total body bone mineral density; LUSC cis rs6500602 0.673 rs1861652 chr16:4505331 C/T cg08645402 chr16:4508243 NA 0.52 8.46 0.42 8.23e-16 Schizophrenia; LUSC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.95 0.4 2.83e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2730245 0.527 rs924910 chr7:158672272 C/T cg24397884 chr7:158709396 WDR60 0.79 8.86 0.44 4.84e-17 Height; LUSC cis rs6845621 0.727 rs2110211 chr4:18917064 A/G cg12196642 chr4:18937545 NA -0.34 -6.34 -0.33 7.56e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg03676636 chr4:99064102 C4orf37 0.35 7.45 0.38 7.89e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg04369109 chr6:150039330 LATS1 -0.6 -8.71 -0.43 1.44e-16 Lung cancer; LUSC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg11663144 chr21:46675770 NA -0.41 -6.97 -0.36 1.66e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg24450063 chr1:156163899 SLC25A44 1.05 17.3 0.69 2.5e-48 Testicular germ cell tumor; LUSC cis rs62408225 1.000 rs1504215 chr6:91006227 G/A cg06866423 chr6:90926672 BACH2 0.43 6.22 0.32 1.49e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg05283184 chr6:79620031 NA -0.56 -11.8 -0.54 4.14e-27 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs4595586 0.525 rs11609150 chr12:39408622 A/C cg26384229 chr12:38710491 ALG10B 0.54 7.65 0.39 2.2e-13 Morning vs. evening chronotype; LUSC cis rs9660992 0.573 rs12140422 chr1:205187981 G/A cg00857998 chr1:205179979 DSTYK 0.64 9.86 0.47 2.73e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs72781680 0.752 rs72796116 chr2:23913769 C/T cg08917208 chr2:24149416 ATAD2B 1.0 10.18 0.49 2.21e-21 Lymphocyte counts; LUSC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg13395646 chr4:1353034 KIAA1530 -0.61 -9.42 -0.46 7.48e-19 Longevity; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg23244062 chr14:93799399 BTBD7;KIAA1409 0.38 5.96 0.31 6.53e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg06108461 chr20:60628389 TAF4 -0.96 -16.54 -0.67 2.55e-45 Body mass index; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.09 0.77 2.83e-67 Prudent dietary pattern; LUSC cis rs9814567 1.000 rs7374325 chr3:134275601 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.6 -0.6 7.94e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2243480 0.522 rs431168 chr7:65511604 G/T cg18252515 chr7:66147081 NA -1.32 -8.8 -0.43 7.39e-17 Diabetic kidney disease; LUSC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg04553112 chr3:125709451 NA -0.48 -5.83 -0.3 1.29e-8 Blood pressure (smoking interaction); LUSC cis rs7312933 0.558 rs55702525 chr12:42814309 T/C cg01256987 chr12:42539512 GXYLT1 0.36 6.61 0.34 1.53e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7172677 0.732 rs2289583 chr15:75311036 C/A cg14664628 chr15:75095509 CSK 0.61 7.94 0.4 3.18e-14 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg16393715 chr7:1948819 MAD1L1 0.36 6.25 0.32 1.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs763121 0.925 rs5750654 chr22:39051428 T/C cg06022373 chr22:39101656 GTPBP1 0.8 13.21 0.59 2.45e-32 Menopause (age at onset); LUSC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg07606381 chr6:8435919 SLC35B3 0.72 12.17 0.55 1.89e-28 Motion sickness; LUSC cis rs10992471 0.756 rs10992303 chr9:95082804 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.49 -8.31 -0.41 2.5e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs3760982 0.626 rs12463370 chr19:44292166 G/A cg11993925 chr19:44307056 LYPD5 0.28 6.26 0.32 1.2e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs8062405 1.000 rs9972693 chr16:28859802 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9487051 0.768 rs427960 chr6:109524939 C/T cg01475377 chr6:109611718 NA -0.35 -5.69 -0.3 2.76e-8 Reticulocyte fraction of red cells; LUSC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg09365446 chr1:150670422 GOLPH3L -0.39 -5.74 -0.3 2.18e-8 Tonsillectomy; LUSC cis rs7582180 0.629 rs12612809 chr2:100951616 G/T cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.41 6.63 0.34 1.38e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6665290 0.870 rs1045289 chr1:227178713 C/T cg10327440 chr1:227177885 CDC42BPA -1.21 -40.51 -0.91 6.17e-131 Myeloid white cell count; LUSC cis rs4363385 0.818 rs12029168 chr1:152987993 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.74 -0.3 2.17e-8 Inflammatory skin disease; LUSC cis rs478304 0.651 rs11604462 chr11:65551648 G/A cg27068330 chr11:65405492 SIPA1 -0.79 -11.16 -0.52 8.64e-25 Acne (severe); LUSC cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg04450456 chr4:17643702 FAM184B -0.35 -5.87 -0.31 1.05e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4604732 0.588 rs7549495 chr1:247627806 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.78 0.35 5.42e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs6700896 0.522 rs4655583 chr1:66155407 C/A cg14976592 chr1:65886160 LEPROT;LEPR 0.51 5.95 0.31 6.86e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs9650657 0.504 rs2409724 chr8:11041642 A/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.19 -0.32 1.76e-9 Neuroticism; LUSC cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg16386425 chr10:429943 DIP2C 0.4 5.87 0.31 1.04e-8 Psychosis in Alzheimer's disease; LUSC cis rs11676348 0.818 rs7426289 chr2:218966315 C/T cg00012203 chr2:219082015 ARPC2 -0.58 -9.25 -0.45 2.73e-18 Ulcerative colitis; LUSC trans rs9944715 0.954 rs1808946 chr18:43854860 A/G cg01718231 chr17:29326311 RNF135 -0.54 -7.54 -0.38 4.52e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs372883 0.901 rs733610 chr21:30656199 G/A cg08807101 chr21:30365312 RNF160 -0.41 -5.81 -0.3 1.46e-8 Pancreatic cancer; LUSC cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg20503657 chr10:835505 NA 0.55 7.2 0.37 4.09e-12 Eosinophil percentage of granulocytes; LUSC cis rs9287719 0.934 rs12692418 chr2:10745870 T/C cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs9326248 0.861 rs4938352 chr11:117027481 G/A cg26566898 chr11:117069891 TAGLN 0.38 6.06 0.31 3.6e-9 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00175859 chr6:138428631 PERP -0.44 -6.7 -0.34 8.79e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4631830 0.720 rs11004422 chr10:51498336 A/G cg20129853 chr10:51489980 NA 0.36 7.4 0.38 1.14e-12 Prostate-specific antigen levels; LUSC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.79 0.47 4.77e-20 Personality dimensions; LUSC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg00310523 chr12:86230176 RASSF9 0.44 7.91 0.4 3.74e-14 Major depressive disorder; LUSC cis rs778371 0.522 rs10205801 chr2:233597196 G/A cg08000102 chr2:233561755 GIGYF2 0.75 12.65 0.57 3.23e-30 Schizophrenia; LUSC cis rs12464559 0.522 rs11676866 chr2:152628858 G/C cg01189475 chr2:152685088 ARL5A 0.65 7.2 0.37 4.04e-12 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg24881330 chr22:46731750 TRMU 0.85 8.4 0.42 1.28e-15 LDL cholesterol;Cholesterol, total; LUSC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.69 -6.61 -0.34 1.5e-10 Cerebrospinal P-tau181p levels; LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.55 0.6 1.23e-33 Platelet count; LUSC cis rs6964587 0.692 rs12536220 chr7:91805595 T/G cg17063962 chr7:91808500 NA 0.58 9.62 0.47 1.68e-19 Breast cancer; LUSC cis rs10887741 0.966 rs2077695 chr10:89435483 T/C cg13926569 chr10:89418898 PAPSS2 0.34 6.7 0.34 8.88e-11 Exercise (leisure time); LUSC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg02772935 chr3:125709198 NA -0.49 -5.87 -0.31 1.04e-8 Blood pressure (smoking interaction); LUSC cis rs10489202 0.583 rs201539 chr1:167995407 A/G cg24449463 chr1:168025552 DCAF6 -0.78 -13.06 -0.58 8.9e-32 Schizophrenia; LUSC cis rs62408225 0.722 rs1319433 chr6:90921988 G/A cg06866423 chr6:90926672 BACH2 0.4 6.24 0.32 1.31e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs71435601 0.628 rs560408 chr2:21398379 T/C cg20757404 chr19:378427 NA 0.37 6.01 0.31 4.87e-9 Cholesterol, total; LUSC cis rs7264396 0.790 rs2425160 chr20:34425968 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.93 -0.44 3.01e-17 Total cholesterol levels; LUSC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg10523679 chr1:76189770 ACADM 0.9 16.2 0.66 5.81e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8063761 0.589 rs4238833 chr16:90050689 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.76 12.04 0.55 5.5e-28 Squamous cell carcinoma; LUSC cis rs7296418 0.738 rs1568428 chr12:123738876 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.34 6.45 0.33 3.86e-10 Platelet count; LUSC cis rs9653442 0.545 rs1821827 chr2:100764717 T/C cg22139774 chr2:100720529 AFF3 -0.42 -7.25 -0.37 2.9e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs870825 0.616 rs7674952 chr4:185622327 A/C cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.83 12.79 0.57 9.42e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg01879757 chr17:41196368 BRCA1 -0.51 -8.2 -0.41 5.4e-15 Menopause (age at onset); LUSC cis rs7267979 1.000 rs6050631 chr20:25431749 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.75 0.73 4.54e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2011503 0.825 rs4808932 chr19:19358819 C/T cg11244672 chr19:19639970 YJEFN3 -0.54 -6.56 -0.34 1.99e-10 Bipolar disorder; LUSC cis rs1957429 0.522 rs73279816 chr14:65348375 G/A cg23373153 chr14:65346875 NA -1.02 -9.25 -0.45 2.73e-18 Pediatric areal bone mineral density (radius); LUSC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -8.52 -0.42 5.37e-16 Type 2 diabetes; LUSC cis rs9581857 0.547 rs9579094 chr13:28081495 G/A cg22138327 chr13:27999177 GTF3A 0.7 7.16 0.36 5.16e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs73200209 0.703 rs17427025 chr12:116677033 C/G cg01776926 chr12:116560359 MED13L -0.46 -5.73 -0.3 2.3e-8 Total body bone mineral density; LUSC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg00310523 chr12:86230176 RASSF9 -0.42 -7.98 -0.4 2.35e-14 Major depressive disorder; LUSC cis rs453301 0.658 rs13271797 chr8:8885954 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.68 -0.39 1.8e-13 Joint mobility (Beighton score); LUSC cis rs910316 0.737 rs91144 chr14:75449517 G/A cg08847533 chr14:75593920 NEK9 -0.81 -13.85 -0.6 9.04e-35 Height; LUSC trans rs8072100 0.840 rs12452796 chr17:45479733 G/T cg04995722 chr7:26192034 NFE2L3 0.38 6.23 0.32 1.37e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9361491 0.657 rs9359344 chr6:79461033 G/A cg05283184 chr6:79620031 NA -0.32 -5.9 -0.31 9.16e-9 Intelligence (multi-trait analysis); LUSC cis rs17401966 0.537 rs3748575 chr1:10342352 C/T cg19773385 chr1:10388646 KIF1B -0.34 -6.12 -0.32 2.6e-9 Hepatocellular carcinoma; LUSC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg13770153 chr20:60521292 NA -0.62 -8.16 -0.41 6.68e-15 Body mass index; LUSC cis rs400736 0.930 rs226251 chr1:8024690 T/C cg25007680 chr1:8021821 PARK7 0.61 9.56 0.46 2.59e-19 Response to antidepressants and depression; LUSC cis rs72634258 0.945 rs28624 chr1:8084355 G/T cg00042356 chr1:8021962 PARK7 -0.67 -8.72 -0.43 1.38e-16 Inflammatory bowel disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24473633 chr8:142138319 DENND3 -0.44 -5.98 -0.31 5.68e-9 Hepatitis; LUSC cis rs250677 1.000 rs40525 chr5:148432932 G/T cg18129178 chr5:148520854 ABLIM3 0.61 9.26 0.45 2.59e-18 Breast cancer; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg15242686 chr22:24348715 GSTTP1 0.43 6.53 0.34 2.49e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs997295 0.713 rs12905509 chr15:67994108 A/G cg08079166 chr15:68083412 MAP2K5 -0.32 -6.48 -0.33 3.24e-10 Motion sickness; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg05025164 chr4:1340916 KIAA1530 0.43 6.65 0.34 1.19e-10 Obesity-related traits; LUSC cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg00677455 chr12:58241039 CTDSP2 0.69 10.48 0.5 2.07e-22 Intelligence (multi-trait analysis); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg09119797 chr1:35658164 SFPQ 0.34 5.98 0.31 5.88e-9 Metabolite levels (Pyroglutamine); LUSC cis rs12464483 0.524 rs2256411 chr2:30886860 C/A cg12454169 chr2:30669597 LCLAT1 0.61 7.82 0.39 7.08e-14 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs4072705 0.615 rs7028021 chr9:127249022 A/G cg13476313 chr9:127244764 NR5A1 0.34 6.48 0.33 3.21e-10 Menarche (age at onset); LUSC cis rs983392 0.868 rs7933202 chr11:59936926 A/C cg20284999 chr11:59952153 MS4A6A -0.36 -5.81 -0.3 1.49e-8 Alzheimer's disease (late onset); LUSC cis rs894734 0.535 rs2366143 chr12:54323256 G/A cg17410650 chr12:54324560 NA -0.57 -10.25 -0.49 1.25e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg09491104 chr22:46646882 C22orf40 -0.67 -7.0 -0.36 1.42e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs2637266 0.935 rs7921790 chr10:78368253 T/C cg18941641 chr10:78392320 NA 0.39 7.06 0.36 9.56e-12 Pulmonary function; LUSC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg06212747 chr3:49208901 KLHDC8B 0.45 5.99 0.31 5.28e-9 Parkinson's disease; LUSC cis rs694739 0.628 rs617051 chr11:64133638 C/A cg23796481 chr11:64053134 BAD;GPR137 0.52 8.14 0.41 8.04e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs11711311 0.910 rs62265549 chr3:113396234 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.94 -0.31 7.28e-9 IgG glycosylation; LUSC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11644478 chr21:40555479 PSMG1 0.88 15.67 0.65 6.95e-42 Cognitive function; LUSC cis rs6500395 1.000 rs1420701 chr16:48730873 C/T cg04672837 chr16:48644449 N4BP1 -0.48 -7.11 -0.36 7.05e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs59698941 0.943 rs60545802 chr5:132204577 T/G cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.57e-11 Apolipoprotein A-IV levels; LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg18404041 chr3:52824283 ITIH1 -0.56 -10.68 -0.5 4.33e-23 Bipolar disorder; LUSC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg11663144 chr21:46675770 NA -0.4 -6.93 -0.35 2.19e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg27446573 chr6:127587934 RNF146 0.67 10.12 0.48 3.54e-21 Breast cancer; LUSC cis rs17490626 0.568 rs12413525 chr10:71211721 C/A cg14388049 chr10:71211838 TSPAN15 -0.32 -5.81 -0.3 1.47e-8 Thrombosis; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.71 0.54 9.03e-27 Prudent dietary pattern; LUSC cis rs2235649 0.798 rs9932983 chr16:1848184 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.07 -0.32 3.56e-9 Blood metabolite levels; LUSC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg14784868 chr12:69753453 YEATS4 0.81 13.83 0.6 1.03e-34 Blood protein levels; LUSC cis rs1144713 0.686 rs1144715 chr12:32261435 A/G cg01321189 chr12:32259338 BICD1 0.43 6.66 0.34 1.12e-10 Obesity-related traits; LUSC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.78 0.39 9.12e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg27124370 chr19:33622961 WDR88 0.58 8.26 0.41 3.54e-15 Bone properties (heel); LUSC cis rs3087591 1.000 rs8068801 chr17:29570587 G/T cg24425628 chr17:29625626 OMG;NF1 -0.57 -8.26 -0.41 3.47e-15 Hip circumference; LUSC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC trans rs7181230 0.885 rs3923235 chr15:40371121 A/G cg22705835 chr10:65332833 REEP3 -0.4 -6.54 -0.34 2.34e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs738322 0.554 rs6001033 chr22:38557513 T/A cg25457927 chr22:38595422 NA -0.34 -6.81 -0.35 4.62e-11 Cutaneous nevi; LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.12 0.66 1.24e-43 Platelet count; LUSC cis rs12594515 1.000 rs12595137 chr15:45986105 G/T cg01629716 chr15:45996671 NA 0.4 5.87 0.31 1.05e-8 Waist circumference;Weight; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg23978390 chr7:1156363 C7orf50 0.48 6.82 0.35 4.33e-11 Longevity;Endometriosis; LUSC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg22508957 chr16:3507546 NAT15 -0.4 -6.35 -0.33 6.88e-10 Body mass index (adult); LUSC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.03e-34 Prostate cancer; LUSC cis rs9300255 0.602 rs941305 chr12:123715266 T/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.94 -0.31 7.31e-9 Neutrophil percentage of white cells; LUSC cis rs10761482 0.861 rs10740027 chr10:62159661 T/C cg18175470 chr10:62150864 ANK3 -0.57 -8.44 -0.42 9.48e-16 Schizophrenia; LUSC cis rs7809950 0.678 rs13230144 chr7:106909172 T/C cg23024343 chr7:107201750 COG5 -0.66 -10.06 -0.48 5.78e-21 Coronary artery disease; LUSC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.1 0.48 4.14e-21 Electroencephalogram traits; LUSC cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.51 7.59e-24 Schizophrenia; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8.19e-17 Bipolar disorder; LUSC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.9 0.48 2.05e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.558 rs7113067 chr11:111692182 G/A cg09085632 chr11:111637200 PPP2R1B 0.93 12.54 0.57 7.95e-30 Primary sclerosing cholangitis; LUSC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg03352830 chr11:487213 PTDSS2 0.71 8.83 0.43 6.13e-17 Body mass index; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg22907277 chr7:1156413 C7orf50 0.51 7.68 0.39 1.74e-13 Longevity;Endometriosis; LUSC cis rs722599 0.961 rs2359239 chr14:75326771 C/T cg08847533 chr14:75593920 NEK9 -0.41 -5.99 -0.31 5.31e-9 IgG glycosylation; LUSC cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg18132916 chr6:79620363 NA -0.37 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.67 11.77 0.54 5.55e-27 Personality dimensions; LUSC cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC cis rs2486288 0.539 rs2433601 chr15:45716425 T/C cg04036182 chr15:45458818 NA 0.35 5.8 0.3 1.5e-8 Glomerular filtration rate; LUSC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg02503808 chr4:7069936 GRPEL1 1.03 13.79 0.6 1.52e-34 Monocyte percentage of white cells; LUSC cis rs9807841 0.592 rs1053007 chr19:10754400 A/G cg17710535 chr19:10819994 QTRT1 0.44 7.27 0.37 2.57e-12 Inflammatory skin disease; LUSC cis rs6714710 0.603 rs17489454 chr2:98407350 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.33e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7267979 1.000 rs2482927 chr20:25327151 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.03 -0.7 3.21e-51 Liver enzyme levels (alkaline phosphatase); LUSC trans rs7647973 0.626 rs4855845 chr3:49687043 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.85 -0.35 3.57e-11 Menarche (age at onset); LUSC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg22535103 chr8:58192502 C8orf71 -0.77 -8.59 -0.43 3.38e-16 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.17e-9 Prudent dietary pattern; LUSC cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg08975724 chr8:8085496 FLJ10661 0.4 5.78 0.3 1.72e-8 Joint mobility (Beighton score); LUSC trans rs3960554 0.808 rs112372188 chr7:75723376 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 9.32 0.45 1.63e-18 Eotaxin levels; LUSC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg13939156 chr17:80058883 NA 0.34 6.72 0.35 7.89e-11 Life satisfaction; LUSC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg27170947 chr2:26402098 FAM59B 0.61 9.28 0.45 2.16e-18 Gut microbiome composition (summer); LUSC cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.91 -0.35 2.4e-11 Menopause (age at onset); LUSC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.04 0.36 1.07e-11 Schizophrenia; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg26356754 chr6:43325264 ZNF318 0.36 6.35 0.33 7.22e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg14440974 chr22:39074834 NA -0.35 -5.93 -0.31 7.55e-9 Menopause (age at onset); LUSC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg20818283 chr2:191399100 TMEM194B 0.43 6.72 0.35 7.81e-11 Pulse pressure; LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs2235649 0.828 rs9925354 chr16:1849866 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.1 -0.32 2.96e-9 Blood metabolite levels; LUSC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg03948781 chr1:205179583 DSTYK 0.3 5.67 0.3 3.04e-8 Mean corpuscular volume;Mean platelet volume; LUSC trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21659725 chr3:3221576 CRBN 0.6 7.99 0.4 2.2e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC trans rs8072100 0.846 rs4264433 chr17:45737275 A/T cg03886242 chr7:26192032 NFE2L3 0.37 6.07 0.32 3.42e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg08975724 chr8:8085496 FLJ10661 -0.51 -7.52 -0.38 5.03e-13 Mood instability; LUSC cis rs2274273 0.745 rs748017 chr14:55542300 A/G cg04306507 chr14:55594613 LGALS3 0.51 10.72 0.51 3.06e-23 Protein biomarker; LUSC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg16545954 chr1:2118288 C1orf86 0.31 5.92 0.31 7.79e-9 Height; LUSC cis rs2708377 0.929 rs73053768 chr12:11155747 A/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.83 8.18 0.41 5.97e-15 Bitter taste perception; LUSC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg08219700 chr8:58056026 NA 0.49 6.06 0.31 3.61e-9 Developmental language disorder (linguistic errors); LUSC cis rs6740322 0.644 rs11690918 chr2:43474112 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.47 -6.02 -0.31 4.72e-9 Coronary artery disease; LUSC trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg25036284 chr2:26402008 FAM59B -0.75 -10.98 -0.52 3.59e-24 Gut microbiome composition (summer); LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs9400467 0.528 rs1989574 chr6:111728533 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.88 -0.35 3.05e-11 Blood metabolite levels;Amino acid levels; LUSC trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg03929089 chr4:120376271 NA 0.68 7.58 0.38 3.49e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.46 -5.75 -0.3 2.02e-8 Schizophrenia; LUSC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC cis rs3008870 1.000 rs3008874 chr1:67431365 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.25 0.64 3.15e-40 Lymphocyte percentage of white cells; LUSC cis rs34779708 0.966 rs10827493 chr10:35454976 C/T cg04310649 chr10:35416472 CREM -0.43 -6.72 -0.35 7.83e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg04155289 chr7:94953770 PON1 -0.35 -5.9 -0.31 8.94e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.57 12.83 0.57 6.67e-31 Hemoglobin concentration; LUSC cis rs9393692 0.627 rs1059486 chr6:26200083 A/G cg00631329 chr6:26305371 NA -0.34 -6.31 -0.33 8.7e-10 Educational attainment; LUSC cis rs12760731 0.565 rs10494511 chr1:178094265 A/G cg00404053 chr1:178313656 RASAL2 0.6 6.06 0.31 3.6e-9 Obesity-related traits; LUSC cis rs9527 0.590 rs12414232 chr10:104914491 A/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.46 -0.33 3.66e-10 Arsenic metabolism; LUSC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg12463550 chr7:65579703 CRCP 0.5 7.02 0.36 1.22e-11 Aortic root size; LUSC cis rs9733 0.687 rs12410050 chr1:150857141 A/G cg04414720 chr1:150670196 GOLPH3L -0.45 -7.04 -0.36 1.13e-11 Tonsillectomy; LUSC cis rs344364 0.602 rs12719796 chr16:1921197 A/G cg00564555 chr16:1970112 NA 0.34 5.99 0.31 5.3300000000000004e-09 Glomerular filtration rate in chronic kidney disease; LUSC trans rs35374984 0.920 rs16930800 chr10:30234268 A/C cg02747044 chr21:38639544 DSCR3 -0.72 -6.28 -0.32 1.08e-9 Emphysema distribution in smoking; LUSC cis rs611744 0.647 rs7015513 chr8:109262570 A/C cg21045802 chr8:109455806 TTC35 0.43 6.69 0.34 9.59e-11 Dupuytren's disease; LUSC trans rs12310956 0.532 rs1352210 chr12:33983187 A/G cg13010199 chr12:38710504 ALG10B 0.48 7.33 0.37 1.73e-12 Morning vs. evening chronotype; LUSC cis rs7824557 0.564 rs2043508 chr8:11227406 G/A cg21775007 chr8:11205619 TDH -0.68 -10.44 -0.5 2.97e-22 Retinal vascular caliber; LUSC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.16 -0.32 2.12e-9 Extrinsic epigenetic age acceleration; LUSC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.54 -0.42 4.8e-16 Personality dimensions; LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg08677398 chr8:58056175 NA 0.54 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg03806693 chr22:41940476 POLR3H 0.98 14.25 0.61 2.56e-36 Vitiligo; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.38 -6.27 -0.32 1.15e-9 Longevity;Endometriosis; LUSC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg20283391 chr11:68216788 NA 0.52 7.74 0.39 1.18e-13 Total body bone mineral density; LUSC cis rs3126085 0.935 rs1552995 chr1:152171427 A/G cg26876637 chr1:152193138 HRNR 0.46 6.82 0.35 4.21e-11 Atopic dermatitis; LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg13560548 chr3:10150139 C3orf24 0.52 7.14 0.36 5.82e-12 Alzheimer's disease; LUSC cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs11168618 0.904 rs12366459 chr12:48930900 C/T cg24011408 chr12:48396354 COL2A1 0.4 6.42 0.33 4.67e-10 Adiponectin levels; LUSC cis rs11122272 0.735 rs971534 chr1:231521971 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs6582630 0.599 rs1589392 chr12:38418535 G/C cg13010199 chr12:38710504 ALG10B -0.44 -6.57 -0.34 1.95e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6546550 0.869 rs6720498 chr2:70124805 T/C cg02498382 chr2:70120550 SNRNP27 -0.29 -7.24 -0.37 3.14e-12 Prevalent atrial fibrillation; LUSC cis rs425277 0.917 rs78609670 chr1:2045886 G/T cg24578937 chr1:2090814 PRKCZ 0.57 12.48 0.56 1.28e-29 Height; LUSC trans rs2204008 0.652 rs11520002 chr12:38022179 G/T cg06521331 chr12:34319734 NA -0.39 -5.95 -0.31 6.77e-9 Bladder cancer; LUSC cis rs11098499 0.789 rs1980024 chr4:120253047 C/T cg24375607 chr4:120327624 NA 0.75 12.08 0.55 4.2e-28 Corneal astigmatism; LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg18404041 chr3:52824283 ITIH1 -0.57 -10.8 -0.51 1.62e-23 Bipolar disorder; LUSC trans rs2370759 0.891 rs76164690 chr10:32590362 T/G cg07829597 chr10:77161705 C10orf41;ZNF503 0.66 6.16 0.32 2.03e-9 Sexual dysfunction (female); LUSC cis rs208520 1.000 rs12192261 chr6:66985268 A/G cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg13175981 chr1:150552382 MCL1 0.49 6.96 0.36 1.83e-11 Tonsillectomy; LUSC cis rs7903847 0.600 rs2275582 chr10:99128983 G/A cg20016023 chr10:99160130 RRP12 -0.28 -6.26 -0.32 1.16e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs2692947 0.770 rs2315421 chr2:96497516 G/C cg22654517 chr2:96458247 NA 0.38 7.56 0.38 3.95e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg11062466 chr8:58055876 NA 0.71 8.53 0.42 5.07e-16 Developmental language disorder (linguistic errors); LUSC cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg18252515 chr7:66147081 NA -1.22 -14.55 -0.62 1.77e-37 Diabetic kidney disease; LUSC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg02782426 chr3:40428986 ENTPD3 0.34 6.45 0.33 4.03e-10 Renal cell carcinoma; LUSC cis rs5756813 0.811 rs4396807 chr22:38138379 G/C cg06521852 chr22:38141419 TRIOBP 0.4 6.33 0.33 7.93e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs2652834 1.000 rs2652832 chr15:63396928 T/C cg05507819 chr15:63340323 TPM1 0.67 8.13 0.41 8.72e-15 HDL cholesterol; LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7937682 0.924 rs7924683 chr11:111555796 C/A cg09085632 chr11:111637200 PPP2R1B -1.09 -17.36 -0.69 1.4e-48 Primary sclerosing cholangitis; LUSC cis rs7584330 0.910 rs66509917 chr2:238395394 T/G cg16989719 chr2:238392110 NA -0.42 -7.45 -0.38 7.96e-13 Prostate cancer; LUSC cis rs34779708 0.733 rs12777960 chr10:35541026 C/A cg03585969 chr10:35415529 CREM 0.55 7.63 0.39 2.51e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7903847 0.642 rs9888026 chr10:99159869 G/T cg20016023 chr10:99160130 RRP12 0.31 7.78 0.39 8.89e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs6429082 0.597 rs6683978 chr1:235541425 A/G cg26050004 chr1:235667680 B3GALNT2 -0.51 -6.89 -0.35 2.74e-11 Adiposity; LUSC cis rs6494488 0.500 rs72741319 chr15:64716977 C/G cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Coronary artery disease; LUSC cis rs6961069 0.671 rs28600997 chr7:80222539 C/T cg04458919 chr7:80252533 CD36 -0.41 -7.16 -0.36 5.3e-12 Platelet count; LUSC cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.48 -0.53 6.18e-26 Mean corpuscular volume; LUSC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg06640241 chr16:89574553 SPG7 0.68 10.74 0.51 2.57e-23 Multiple myeloma (IgH translocation); LUSC cis rs4356932 0.967 rs13128319 chr4:76975206 A/G cg00809888 chr4:76862425 NAAA -0.35 -5.91 -0.31 8.42e-9 Blood protein levels; LUSC cis rs11958404 0.929 rs72816533 chr5:157413352 G/T cg05962755 chr5:157440814 NA 0.51 6.25 0.32 1.28e-9 IgG glycosylation; LUSC cis rs243505 0.559 rs734003 chr7:148505498 T/G cg09806900 chr7:148480153 CUL1 0.67 9.97 0.48 1.14e-20 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7568458 0.846 rs1078004 chr2:85769711 C/G cg17127132 chr2:85788382 GGCX 0.45 7.08 0.36 8.53e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10779751 0.960 rs4845857 chr1:11285680 T/C cg08854313 chr1:11322531 MTOR 0.89 14.58 0.62 1.27e-37 Body mass index; LUSC cis rs7264396 0.528 rs7273880 chr20:34551507 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC trans rs2898290 0.622 rs7822109 chr8:11349147 T/C cg15556689 chr8:8085844 FLJ10661 -0.54 -8.54 -0.42 4.9e-16 Systolic blood pressure; LUSC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC cis rs9393777 0.720 rs34864993 chr6:26970895 C/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.55 -6.34 -0.33 7.33e-10 Intelligence (multi-trait analysis); LUSC cis rs6430585 0.583 rs12475516 chr2:136560761 C/G cg07169764 chr2:136633963 MCM6 0.98 13.72 0.6 2.83e-34 Corneal structure; LUSC cis rs1832871 0.711 rs9459826 chr6:158680396 C/G cg07165851 chr6:158734300 TULP4 -0.5 -7.67 -0.39 1.9e-13 Height; LUSC cis rs9472414 0.771 rs720988 chr6:44765660 C/T cg20913747 chr6:44695427 NA 0.4 5.74 0.3 2.17e-8 Height; LUSC cis rs2732480 0.577 rs2450994 chr12:48721832 G/A cg04545296 chr12:48745243 ZNF641 0.34 6.26 0.32 1.2e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs6456156 0.806 rs11967165 chr6:167529936 T/C cg07741184 chr6:167504864 NA -0.35 -6.23 -0.32 1.37e-9 Primary biliary cholangitis; LUSC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg03146154 chr1:46216737 IPP -0.56 -8.41 -0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9653442 0.900 rs1160544 chr2:100832218 A/C cg22139774 chr2:100720529 AFF3 -0.47 -8.21 -0.41 4.89e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7621025 0.500 rs9845460 chr3:136587117 A/G cg15507776 chr3:136538369 TMEM22 0.58 7.97 0.4 2.5e-14 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC trans rs7307780 0.703 rs7965922 chr12:76230735 C/T cg05238905 chr6:149867353 PPIL4 0.63 5.97 0.31 6.14e-9 Sudden cardiac arrest; LUSC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg06634786 chr22:41940651 POLR3H -0.5 -6.24 -0.32 1.29e-9 Vitiligo; LUSC cis rs4631830 0.863 rs4554834 chr10:51530146 A/C cg10326726 chr10:51549505 MSMB -0.37 -6.32 -0.33 8.4e-10 Prostate-specific antigen levels; LUSC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg21862992 chr11:68658383 NA 0.51 8.11 0.41 9.88e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs8078723 1.000 rs4795412 chr17:38150604 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.42 -6.75 -0.35 6.54e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg06028605 chr16:24865363 SLC5A11 -0.4 -6.54 -0.34 2.28e-10 Intelligence (multi-trait analysis); LUSC cis rs733592 1.000 rs1859440 chr12:48427329 T/C cg24011408 chr12:48396354 COL2A1 -0.46 -7.65 -0.39 2.1e-13 Plateletcrit; LUSC cis rs7312933 0.703 rs7957471 chr12:42545591 G/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.83 0.35 3.91e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg00852783 chr1:26633632 UBXN11 0.6 9.58 0.46 2.23e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs9473147 0.516 rs9395286 chr6:47575332 T/C cg12968598 chr6:47444699 CD2AP 0.53 8.08 0.4 1.24e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs11676348 0.808 rs4674267 chr2:219046437 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.39 -5.99 -0.31 5.37e-9 Ulcerative colitis; LUSC cis rs72781680 1.000 rs72781663 chr2:24221694 C/G cg20701182 chr2:24300061 SF3B14 0.59 6.26 0.32 1.18e-9 Lymphocyte counts; LUSC trans rs35110281 0.627 rs7283362 chr21:44973667 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.86 0.47 2.69e-20 Mean corpuscular volume; LUSC cis rs4919687 0.550 rs7904252 chr10:104456725 A/C cg05855489 chr10:104503620 C10orf26 -0.66 -10.69 -0.5 3.91e-23 Colorectal cancer; LUSC cis rs1577917 0.793 rs9362245 chr6:86496320 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -6.46 -0.33 3.63e-10 Response to antipsychotic treatment; LUSC cis rs950776 0.518 rs12910100 chr15:78822667 C/T cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg24739457 chr1:205821442 NA 0.4 7.2 0.37 4.06e-12 Menarche (age at onset); LUSC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg09323728 chr8:95962352 TP53INP1 -0.4 -7.93 -0.4 3.44e-14 Type 2 diabetes; LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.05 0.31 3.95e-9 Menopause (age at onset); LUSC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg22920501 chr2:26401640 FAM59B -0.73 -10.34 -0.49 6.17e-22 Gut microbiome composition (summer); LUSC cis rs7647973 0.626 rs7637711 chr3:49829653 A/G cg13072238 chr3:49761600 GMPPB 0.64 8.2 0.41 5.24e-15 Menarche (age at onset); LUSC cis rs17092148 1.000 rs2425004 chr20:33405956 G/T cg16810054 chr20:33298113 TP53INP2 0.43 6.81 0.35 4.68e-11 Neuroticism; LUSC cis rs11676348 0.846 rs4674259 chr2:218991005 C/T cg00012203 chr2:219082015 ARPC2 -0.57 -8.96 -0.44 2.39e-17 Ulcerative colitis; LUSC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg05585544 chr11:47624801 NA -0.42 -7.22 -0.37 3.5e-12 Subjective well-being; LUSC cis rs7202877 0.610 rs7202284 chr16:75374346 A/T cg04384234 chr16:75411784 CFDP1 -0.61 -8.24 -0.41 4.07e-15 Type 2 diabetes;Type 1 diabetes; LUSC cis rs765787 0.530 rs12440321 chr15:45529385 G/A cg24006582 chr15:45444508 DUOX1 0.67 9.66 0.47 1.21e-19 Uric acid levels; LUSC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg11102782 chr19:18549136 ISYNA1 -0.35 -6.55 -0.34 2.15e-10 Breast cancer; LUSC cis rs9660992 0.573 rs1172147 chr1:205225457 G/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.28 -0.45 2.16e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7493 0.901 rs11767787 chr7:95026753 T/C cg17330251 chr7:94953956 PON1 -0.35 -5.84 -0.3 1.22e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs12410462 0.581 rs6675521 chr1:227544702 C/T cg23173402 chr1:227635558 NA 0.55 6.39 0.33 5.42e-10 Major depressive disorder; LUSC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg07952391 chr2:88470173 THNSL2 -0.75 -6.49 -0.33 3.06e-10 Plasma clusterin levels; LUSC cis rs8114671 0.967 rs4911476 chr20:33780768 A/C cg07148914 chr20:33460835 GGT7 -0.43 -6.42 -0.33 4.55e-10 Height; LUSC trans rs2794256 0.503 rs706858 chr6:120038177 C/T cg07064544 chr20:43029994 HNF4A 0.32 6.09 0.32 3.15e-9 Spontaneous preterm birth (preterm birth); LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg22907277 chr7:1156413 C7orf50 0.4 6.27 0.32 1.12e-9 Longevity;Endometriosis; LUSC cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg26373071 chr5:1325741 CLPTM1L 0.43 8.09 0.4 1.14e-14 Lung cancer; LUSC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2370759 1.000 rs11594459 chr10:32561858 A/C cg01819863 chr10:32635814 EPC1 1.05 12.98 0.58 1.8e-31 Sexual dysfunction (female); LUSC trans rs7726839 0.561 rs56410216 chr5:583216 C/A cg25482853 chr8:67687455 SGK3 1.03 15.45 0.65 5.41e-41 Obesity-related traits; LUSC cis rs4961252 0.505 rs4961327 chr8:142102053 C/T cg13924514 chr8:142070760 NA -0.34 -5.7 -0.3 2.59e-8 Isovolumetric relaxation time;Response to interferon beta therapy; LUSC cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.66 8.97 0.44 2.17e-17 Multiple sclerosis; LUSC cis rs7617773 0.780 rs13067450 chr3:48337206 C/T cg11946769 chr3:48343235 NME6 0.88 14.29 0.62 1.69e-36 Coronary artery disease; LUSC cis rs11122272 0.735 rs2486735 chr1:231521778 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg11343870 chr11:67888858 CHKA 0.43 6.04 0.31 4.12e-9 Mosquito bite size; LUSC cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg08355456 chr11:67383691 NA -0.37 -6.55 -0.34 2.19e-10 Mean corpuscular volume; LUSC cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg08807101 chr21:30365312 RNF160 0.8 15.45 0.65 5.33e-41 Dental caries; LUSC cis rs13089785 0.965 rs67028142 chr3:123635213 A/G cg19611163 chr3:123411211 MYLK 0.34 5.72 0.3 2.4e-8 Intelligence (multi-trait analysis); LUSC cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg17507749 chr15:85114479 UBE2QP1 0.56 7.19 0.37 4.31e-12 Schizophrenia; LUSC cis rs1549118 0.560 rs11848126 chr14:78318268 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.44 -5.79 -0.3 1.62e-8 Resting heart rate; LUSC trans rs7824557 0.767 rs3808509 chr8:11163256 G/T cg08975724 chr8:8085496 FLJ10661 0.45 6.66 0.34 1.1e-10 Retinal vascular caliber; LUSC cis rs4764124 0.646 rs10846062 chr12:14965781 T/C cg19759883 chr12:14956454 WBP11;C12orf60 0.37 5.74 0.3 2.11e-8 Pubertal anthropometrics; LUSC cis rs868036 0.681 rs28670272 chr15:68109907 C/T cg05925327 chr15:68127851 NA 0.38 6.16 0.32 2.05e-9 Restless legs syndrome; LUSC cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14442939 chr10:27389572 ANKRD26 0.85 9.51 0.46 3.89e-19 Breast cancer; LUSC cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg23649088 chr2:200775458 C2orf69 0.59 7.24 0.37 3.17e-12 Schizophrenia; LUSC cis rs4343996 0.727 rs7797018 chr7:3386840 G/T cg21248987 chr7:3385318 SDK1 -0.37 -6.23 -0.32 1.37e-9 Motion sickness; LUSC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9323205 0.765 rs12232228 chr14:51658072 A/G cg23942311 chr14:51606299 NA 0.3 6.27 0.32 1.14e-9 Cancer; LUSC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -11.7 -0.54 1.01e-26 Chronic sinus infection; LUSC cis rs9467773 1.000 rs9393729 chr6:26514166 C/T cg09904177 chr6:26538194 HMGN4 0.75 14.22 0.61 3.36e-36 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg05084668 chr3:125655381 ALG1L -0.49 -7.01 -0.36 1.33e-11 Blood pressure (smoking interaction); LUSC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg20744362 chr22:50050164 C22orf34 0.41 8.48 0.42 7.37e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs427941 0.667 rs201436 chr7:101733576 T/C cg06246474 chr7:101738831 CUX1 0.41 6.7 0.34 8.72e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs300703 0.935 rs7568664 chr2:280939 A/G cg21211680 chr2:198530 NA 0.72 7.52 0.38 5.09e-13 Blood protein levels; LUSC cis rs12908161 0.959 rs35557864 chr15:85331629 A/G cg17173187 chr15:85201210 NMB 0.48 8.78 0.43 8.71e-17 Schizophrenia; LUSC cis rs6500602 0.855 rs1139652 chr16:4476089 T/C cg08645402 chr16:4508243 NA 0.51 8.11 0.41 9.7e-15 Schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22605943 chr3:107243790 BBX -0.45 -6.2 -0.32 1.69e-9 Hepatitis; LUSC cis rs61931739 0.534 rs1826144 chr12:34094272 A/G cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg05985134 chr18:33552581 C18orf21 0.51 7.02 0.36 1.27e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg03676636 chr4:99064102 C4orf37 -0.35 -7.63 -0.39 2.5e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11644478 chr21:40555479 PSMG1 0.93 18.29 0.71 2.88e-52 Cognitive function; LUSC cis rs4356932 1.000 rs7670789 chr4:76940381 G/A cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.47e-8 Blood protein levels; LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs9457247 1.000 rs404222 chr6:167402150 G/A cg07741184 chr6:167504864 NA 0.4 7.07 0.36 9.16e-12 Crohn's disease; LUSC cis rs6138458 1.000 rs2387361 chr20:24899905 C/T cg06937882 chr20:24974362 C20orf3 0.42 7.0 0.36 1.43e-11 Blood protein levels; LUSC cis rs9926296 0.632 rs7184315 chr16:89799373 C/G cg04287289 chr16:89883240 FANCA -0.51 -7.82 -0.39 6.78e-14 Vitiligo; LUSC cis rs6977940 0.818 rs73033466 chr7:2902617 G/C cg19731401 chr7:2775893 GNA12 0.68 7.79 0.39 8.66e-14 White matter integrity; LUSC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg06108461 chr20:60628389 TAF4 -0.75 -12.49 -0.56 1.25e-29 Body mass index; LUSC cis rs9300255 0.602 rs1716177 chr12:123655457 C/T cg13010344 chr12:123464640 ARL6IP4 -0.44 -6.04 -0.31 4.09e-9 Neutrophil percentage of white cells; LUSC cis rs4820539 0.966 rs2267000 chr22:23455366 A/G cg14186256 chr22:23484241 RTDR1 0.95 17.44 0.69 6.76e-49 Bone mineral density; LUSC trans rs61931739 0.500 rs11053193 chr12:34438838 G/T cg13010199 chr12:38710504 ALG10B 0.69 10.77 0.51 2.01e-23 Morning vs. evening chronotype; LUSC cis rs7937682 0.921 rs11213945 chr11:111461003 A/G cg19812747 chr11:111475976 SIK2 0.53 7.53 0.38 4.86e-13 Primary sclerosing cholangitis; LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg13685833 chr1:53393034 SCP2 -0.37 -5.67 -0.3 3.08e-8 Monocyte count; LUSC cis rs1997103 0.834 rs10274457 chr7:55390199 G/A cg17469321 chr7:55412551 NA 0.68 10.92 0.51 5.92e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9399401 0.710 rs12197866 chr6:142706063 C/T cg03128060 chr6:142623767 GPR126 0.61 9.98 0.48 1.1e-20 Chronic obstructive pulmonary disease; LUSC trans rs61931739 0.500 rs7133447 chr12:34041901 A/G cg26384229 chr12:38710491 ALG10B 0.67 10.61 0.5 7.65e-23 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs10256972 0.630 rs10282584 chr7:1081442 C/T cg20821713 chr7:1055600 C7orf50 -0.38 -6.11 -0.32 2.8e-9 Longevity;Endometriosis; LUSC cis rs752010 0.746 rs10890146 chr1:42089389 G/A cg06885757 chr1:42089581 HIVEP3 0.52 11.17 0.52 8.18e-25 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg10621924 chr7:39171070 POU6F2 0.43 6.54 0.34 2.3e-10 IgG glycosylation; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg14004847 chr7:1930337 MAD1L1 -0.57 -8.79 -0.43 8e-17 Bipolar disorder and schizophrenia; LUSC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg05855489 chr10:104503620 C10orf26 -0.76 -12.93 -0.58 2.72e-31 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg04518342 chr5:131593106 PDLIM4 0.33 5.74 0.3 2.12e-8 Breast cancer;Mosquito bite size; LUSC cis rs61935443 0.720 rs10859783 chr12:95285339 A/G cg21533806 chr12:95267307 NA 0.5 6.24 0.32 1.29e-9 Schizophrenia; LUSC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg21770322 chr7:97807741 LMTK2 0.41 7.28 0.37 2.36e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7264396 0.676 rs6060723 chr20:34549947 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.84 -0.35 3.9e-11 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01881255 chr19:40950703 SERTAD3 -0.43 -6.42 -0.33 4.81e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7617773 0.817 rs9818937 chr3:48325281 G/A cg20734569 chr3:48348370 SPINK8 -0.47 -8.24 -0.41 3.9e-15 Coronary artery disease; LUSC cis rs9326248 0.954 rs8521 chr11:117067699 C/T cg20608306 chr11:116969690 SIK3 0.38 6.27 0.32 1.12e-9 Blood protein levels; LUSC cis rs8017423 0.935 rs11628906 chr14:90738002 C/T cg04374321 chr14:90722782 PSMC1 -0.68 -10.45 -0.5 2.67e-22 Mortality in heart failure; LUSC cis rs7312933 0.510 rs10880223 chr12:42413443 G/A cg01256987 chr12:42539512 GXYLT1 -0.59 -12.38 -0.56 3.09e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs425277 0.539 rs3107142 chr1:2044542 T/C cg24578937 chr1:2090814 PRKCZ -0.44 -9.79 -0.47 4.79e-20 Height; LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg08736216 chr1:53307985 ZYG11A 0.3 6.16 0.32 2.04e-9 Monocyte count; LUSC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg03354898 chr7:1950403 MAD1L1 -0.35 -6.85 -0.35 3.67e-11 Schizophrenia; LUSC cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs34421088 0.506 rs7813424 chr8:11144517 G/A cg15556689 chr8:8085844 FLJ10661 0.46 6.7 0.34 8.78e-11 Neuroticism; LUSC cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg27129171 chr3:47204927 SETD2 0.73 12.7 0.57 2e-30 Colorectal cancer; LUSC cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg05340658 chr4:99064831 C4orf37 0.68 11.63 0.54 1.84e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9549260 0.753 rs9532563 chr13:41160270 T/C cg21288729 chr13:41239152 FOXO1 0.51 6.09 0.32 3.17e-9 Red blood cell count; LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg18595196 chr3:52726726 GNL3;SNORD69 0.29 5.71 0.3 2.5e-8 Bipolar disorder; LUSC cis rs7493 0.851 rs11770903 chr7:95026327 A/G cg17330251 chr7:94953956 PON1 -0.35 -5.73 -0.3 2.22e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1799949 0.587 rs1824890 chr17:41421904 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.42 5.78 0.3 1.72e-8 Menopause (age at onset); LUSC cis rs4746818 1.000 rs10733850 chr10:70959617 C/T cg11621586 chr10:70884670 VPS26A 1.14 11.13 0.52 1.13e-24 Left atrial antero-posterior diameter; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24747780 chr7:75072203 POM121C 0.39 6.09 0.32 3.1e-9 Asthma; LUSC cis rs12421382 0.507 rs11600810 chr11:109356443 G/A cg27471124 chr11:109292789 C11orf87 0.55 9.78 0.47 4.89e-20 Schizophrenia; LUSC cis rs965469 0.846 rs7271575 chr20:3333877 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.3 3.4e-8 IFN-related cytopenia; LUSC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.85 -0.63 1.22e-38 Total body bone mineral density; LUSC cis rs6580649 0.941 rs17122612 chr12:48459488 C/G cg24011408 chr12:48396354 COL2A1 -0.46 -6.17 -0.32 2.03e-9 Lung cancer; LUSC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.79 0.35 5.03e-11 Intelligence (multi-trait analysis); LUSC cis rs11997175 0.603 rs4739381 chr8:33806892 C/A ch.8.33884649F chr8:33765107 NA 0.42 6.36 0.33 6.55e-10 Body mass index; LUSC cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg13319975 chr6:146136371 FBXO30 -0.54 -8.2 -0.41 5.37e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7180079 1.000 rs11633312 chr15:64594611 T/C cg02848875 chr15:64387786 SNX1 0.4 5.67 0.3 3.17e-8 Monocyte count; LUSC cis rs7769051 0.522 rs6934190 chr6:133116664 G/A cg07930552 chr6:133119739 C6orf192 0.95 8.49 0.42 7.03e-16 Type 2 diabetes nephropathy; LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg22535103 chr8:58192502 C8orf71 -0.65 -7.36 -0.37 1.44e-12 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg20887711 chr4:1340912 KIAA1530 -0.48 -7.25 -0.37 3e-12 Obesity-related traits; LUSC cis rs6940638 0.688 rs6921388 chr6:27080205 A/G cg12292205 chr6:26970375 C6orf41 -0.39 -5.79 -0.3 1.61e-8 Intelligence (multi-trait analysis); LUSC cis rs868036 1.000 rs1871307 chr15:68100623 C/T cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs10193935 0.901 rs871045 chr2:42609431 G/C cg27598129 chr2:42591480 NA -0.64 -8.59 -0.43 3.26e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.903 rs2500400 chr20:25354705 A/G cg08601574 chr20:25228251 PYGB -0.44 -6.78 -0.35 5.32e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6542838 0.611 rs1878589 chr2:99517979 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.53 -7.12 -0.36 6.46e-12 Fear of minor pain; LUSC cis rs11190604 0.945 rs2495746 chr10:102328270 T/C cg16342193 chr10:102329863 NA -0.35 -6.51 -0.34 2.83e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.05 0.44 1.25e-17 Total body bone mineral density; LUSC trans rs11696501 0.739 rs6073815 chr20:44234615 A/T cg03272292 chr12:48577362 C12orf68 0.51 5.99 0.31 5.36e-9 Brain structure; LUSC trans rs208520 0.955 rs9453664 chr6:66976079 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 12.16 0.55 2e-28 Exhaled nitric oxide output; LUSC cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg26647111 chr11:31128758 NA -0.42 -6.03 -0.31 4.44e-9 Red blood cell count; LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.18 0.37 4.43e-12 Platelet count; LUSC cis rs10492096 0.947 rs61918020 chr12:6605514 C/T cg13857086 chr12:6580257 VAMP1 0.61 7.25 0.37 2.89e-12 Hip geometry; LUSC cis rs9341835 0.518 rs6939983 chr6:64173216 C/T cg03326410 chr6:64151739 NA -0.37 -6.01 -0.31 4.85e-9 Schizophrenia; LUSC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg26380479 chr7:97908229 NA -0.28 -6.23 -0.32 1.4e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1865760 0.516 rs9393683 chr6:26066198 A/G cg16482183 chr6:26056742 HIST1H1C 0.56 8.43 0.42 1.01e-15 Height; LUSC cis rs7681440 0.904 rs1372521 chr4:90765223 G/A cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs45535039 1.000 rs45535039 chr11:119060963 T/C cg16724696 chr11:118992527 HINFP 0.49 6.03 0.31 4.38e-9 Plateletcrit; LUSC cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.05 0.44 1.21e-17 Motion sickness; LUSC cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg23649088 chr2:200775458 C2orf69 -0.52 -7.04 -0.36 1.13e-11 Schizophrenia; LUSC cis rs1969253 0.632 rs865808 chr3:183858939 G/T cg21665078 chr3:183852786 EIF2B5 -0.42 -7.04 -0.36 1.13e-11 Major depressive disorder; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg14016680 chr3:197687242 LMLN;IQCG 0.46 6.09 0.32 3.17e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11690935 0.632 rs11690807 chr2:172628120 G/A cg13550731 chr2:172543902 DYNC1I2 0.6 9.37 0.46 1.08e-18 Schizophrenia; LUSC cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.3 0.85 2.51e-94 Chronic sinus infection; LUSC cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg24642439 chr20:33292090 TP53INP2 0.62 9.57 0.46 2.42e-19 Coronary artery disease; LUSC cis rs7715806 0.500 rs72633983 chr5:75002845 C/T cg19683494 chr5:74908142 NA 0.58 7.79 0.39 8.27e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs11250464 0.804 rs11250463 chr10:1406228 T/C cg08668359 chr10:1443807 ADARB2 0.41 6.33 0.33 7.92e-10 Radiation response; LUSC cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg05347473 chr6:146136440 FBXO30 0.38 6.17 0.32 2.01e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs853679 0.607 rs13217619 chr6:28306671 T/C cg01620082 chr3:125678407 NA -0.86 -7.42 -0.38 9.7e-13 Depression; LUSC cis rs7584330 0.868 rs13408361 chr2:238382899 A/G cg14458575 chr2:238380390 NA 0.68 11.41 0.53 1.06e-25 Prostate cancer; LUSC trans rs9929218 0.817 rs3114404 chr16:68722096 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.89 -13.45 -0.59 2.87e-33 Colorectal cancer; LUSC cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg20701182 chr2:24300061 SF3B14 -0.45 -5.72 -0.3 2.42e-8 Asthma; LUSC trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg13615516 chr5:77269221 NA 0.38 6.43 0.33 4.39e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6840360 1.000 rs2840130 chr4:152600699 T/C cg22705602 chr4:152727874 NA -0.27 -5.64 -0.3 3.55e-8 Intelligence (multi-trait analysis); LUSC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg21951975 chr1:209979733 IRF6 0.41 6.82 0.35 4.31e-11 Monobrow; LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg08200582 chr11:442649 ANO9 -0.53 -6.13 -0.32 2.49e-9 Body mass index; LUSC cis rs7953508 0.506 rs1316740 chr12:93968288 C/A cg18151635 chr12:93972918 NA -0.62 -8.89 -0.44 3.85e-17 Pubertal anthropometrics; LUSC cis rs1538970 0.962 rs7532762 chr1:45864695 C/A cg06784218 chr1:46089804 CCDC17 0.31 5.72 0.3 2.38e-8 Platelet count; LUSC cis rs8099014 0.954 rs4245271 chr18:56114063 A/G cg12907477 chr18:56117327 MIR122 0.44 7.14 0.36 5.8e-12 Platelet count; LUSC cis rs1448094 0.617 rs4842569 chr12:86468609 T/G cg00310523 chr12:86230176 RASSF9 -0.34 -6.22 -0.32 1.5e-9 Major depressive disorder; LUSC cis rs708547 0.581 rs10020462 chr4:57825593 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.41 6.14 0.32 2.3e-9 Response to bleomycin (chromatid breaks); LUSC cis rs8114671 0.869 rs2038503 chr20:33675900 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -6.04 -0.31 4.06e-9 Height; LUSC cis rs1953600 1.000 rs2573346 chr10:81918041 G/A cg00277334 chr10:82204260 NA -0.5 -7.95 -0.4 2.82e-14 Sarcoidosis; LUSC cis rs2046867 0.818 rs6786469 chr3:72873809 A/G cg25664220 chr3:72788482 NA -0.72 -11.55 -0.53 3.46e-26 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7615952 0.605 rs34865555 chr3:125304134 C/T cg05084668 chr3:125655381 ALG1L -0.56 -6.53 -0.34 2.44e-10 Blood pressure (smoking interaction); LUSC cis rs12579753 1.000 rs12367791 chr12:82237278 C/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs9650657 0.537 rs11250092 chr8:10786543 A/G cg27411982 chr8:10470053 RP1L1 0.46 7.18 0.37 4.46e-12 Neuroticism; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg11062466 chr8:58055876 NA 0.75 9.1 0.45 8.12e-18 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg16132339 chr22:24313637 DDTL;DDT 0.41 6.4 0.33 5.28e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7119 0.651 rs8041520 chr15:77839169 C/T cg27398640 chr15:77910606 LINGO1 -0.32 -6.5 -0.34 2.87e-10 Type 2 diabetes; LUSC cis rs929354 0.713 rs3802130 chr7:156965237 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs3857536 0.785 rs2157964 chr6:66938419 A/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs1691799 0.899 rs1168325 chr12:66728234 C/G cg16791601 chr12:66731901 HELB -0.71 -12.4 -0.56 2.68e-29 White blood cell count (basophil); LUSC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg11764359 chr7:65958608 NA 0.55 7.28 0.37 2.49e-12 Aortic root size; LUSC cis rs35079168 0.661 rs3118529 chr9:137304915 C/T cg14344989 chr9:137329237 RXRA -0.4 -6.5 -0.34 2.86e-10 Intelligence; LUSC cis rs17270561 0.609 rs3922842 chr6:25736564 T/C cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.5 0.42 6.45e-16 Hemoglobin concentration; LUSC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg25554036 chr4:6271136 WFS1 -0.54 -10.23 -0.49 1.56e-21 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6681460 1.000 rs9662943 chr1:67121132 A/G cg02459107 chr1:67143332 SGIP1 -0.48 -8.96 -0.44 2.33e-17 Presence of antiphospholipid antibodies; LUSC cis rs7937682 1.000 rs2186839 chr11:111534442 T/G cg19812747 chr11:111475976 SIK2 -0.45 -6.23 -0.32 1.38e-9 Primary sclerosing cholangitis; LUSC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg23985595 chr17:80112537 CCDC57 -0.31 -5.9 -0.31 9.1e-9 Life satisfaction; LUSC cis rs1568889 1.000 rs7945367 chr11:28166272 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 9.2 0.45 3.96e-18 Bipolar disorder; LUSC cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.5 -0.46 4.36e-19 Chronic sinus infection; LUSC cis rs9462027 0.628 rs9462010 chr6:34716605 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.9 -0.31 9.02e-9 Systemic lupus erythematosus; LUSC cis rs7267979 1.000 rs2297497 chr20:25297909 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -21.2 -0.76 8.74e-64 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1577917 0.681 rs4707211 chr6:86232710 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 7.13 0.36 6.38e-12 Response to antipsychotic treatment; LUSC cis rs8060686 0.668 rs9932414 chr16:68219969 A/G cg26727032 chr16:67993705 SLC12A4 -0.41 -6.36 -0.33 6.67e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC cis rs73416724 1.000 rs17209379 chr6:43265231 A/C cg26312998 chr6:43337775 ZNF318 0.56 6.32 0.33 8.29e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.98 -22.15 -0.77 1.53e-67 Prudent dietary pattern; LUSC cis rs9527 0.545 rs11191602 chr10:104954219 C/T cg05855489 chr10:104503620 C10orf26 0.5 7.7 0.39 1.59e-13 Arsenic metabolism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06386278 chr11:86013177 C11orf73 -0.42 -6.04 -0.31 4.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12579753 0.956 rs35278765 chr12:82173126 T/C cg07988820 chr12:82153109 PPFIA2 -0.44 -6.2 -0.32 1.7e-9 Resting heart rate; LUSC trans rs877282 0.583 rs11595057 chr10:819203 A/C cg22713356 chr15:30763199 NA 0.7 9.5 0.46 4.07e-19 Uric acid levels; LUSC cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.93 -0.31 7.69e-9 IgG glycosylation; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg08859206 chr1:53392774 SCP2 0.51 8.74 0.43 1.14e-16 Monocyte count; LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg00166722 chr3:10149974 C3orf24 -0.61 -7.93 -0.4 3.25e-14 Alzheimer's disease; LUSC cis rs9348739 1 rs9348739 chr6:26923099 G/C cg12826209 chr6:26865740 GUSBL1 0.79 7.84 0.39 6.12e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg17633681 chr16:88106987 BANP 0.53 10.15 0.49 2.88e-21 Menopause (age at onset); LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.8 0.47 4.35e-20 Major depressive disorder; LUSC cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg07493874 chr5:1342172 CLPTM1L -0.28 -5.88 -0.31 9.81e-9 Lung cancer; LUSC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg05890377 chr2:74357713 NA 0.7 13.48 0.59 2.38e-33 Gestational age at birth (maternal effect); LUSC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg07424592 chr7:64974309 NA -0.63 -5.65 -0.3 3.53e-8 Diabetic kidney disease; LUSC cis rs11716531 0.574 rs13075192 chr3:27279235 C/T cg02860705 chr3:27208620 NA 0.62 10.21 0.49 1.72e-21 Diastolic blood pressure; LUSC cis rs1577917 1.000 rs12201741 chr6:86602619 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.32 -0.41 2.32e-15 Response to antipsychotic treatment; LUSC cis rs1577917 1.000 rs7766645 chr6:86622238 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs7659604 0.540 rs11734075 chr4:122695685 C/T cg20573242 chr4:122745356 CCNA2 -0.45 -6.49 -0.33 3.16e-10 Type 2 diabetes; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg21951975 chr1:209979733 IRF6 0.77 16.58 0.67 1.8e-45 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg07092213 chr7:1199455 ZFAND2A -0.64 -10.82 -0.51 1.34e-23 Longevity;Endometriosis; LUSC cis rs6496044 0.568 rs6496066 chr15:86075462 A/C cg13263323 chr15:86062960 AKAP13 -0.37 -6.16 -0.32 2.06e-9 Interstitial lung disease; LUSC cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg17892150 chr10:133769511 PPP2R2D -0.68 -9.51 -0.46 4.05e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17282769 chr12:11802362 ETV6 -0.48 -5.96 -0.31 6.45e-9 Bipolar disorder and schizophrenia; LUSC cis rs7582180 0.629 rs12621892 chr2:100947124 G/C cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg09365446 chr1:150670422 GOLPH3L -0.42 -6.31 -0.33 8.88e-10 Lymphocyte counts; LUSC cis rs2970818 0.831 rs10849086 chr12:4645400 G/A cg11146114 chr12:4671731 NA -0.57 -5.77 -0.3 1.82e-8 Phosphorus levels; LUSC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg07211511 chr3:129823064 LOC729375 1.13 17.52 0.69 3.45e-49 Blood pressure (smoking interaction); LUSC cis rs1577917 0.958 rs7739241 chr6:86575796 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.22 -0.32 1.45e-9 Response to antipsychotic treatment; LUSC cis rs61931739 0.635 rs10772122 chr12:33964674 A/C cg06521331 chr12:34319734 NA -0.41 -6.88 -0.35 2.92e-11 Morning vs. evening chronotype; LUSC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.71 6.68 0.34 9.92e-11 Cerebrospinal P-tau181p levels; LUSC cis rs459571 0.920 rs455073 chr9:136909141 G/C cg01294253 chr9:136912663 BRD3 0.34 5.76 0.3 1.9e-8 Platelet distribution width; LUSC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg17971929 chr21:40555470 PSMG1 -0.78 -13.45 -0.59 2.9e-33 Cognitive function; LUSC cis rs3126085 0.867 rs12027899 chr1:152253954 C/A cg26876637 chr1:152193138 HRNR 0.45 6.08 0.32 3.31e-9 Atopic dermatitis; LUSC cis rs6121246 0.529 rs6088814 chr20:30218172 C/T cg18721089 chr20:30220636 NA -0.39 -6.12 -0.32 2.66e-9 Mean corpuscular hemoglobin; LUSC cis rs8028182 0.583 rs9944207 chr15:75912889 A/T cg20655648 chr15:75932815 IMP3 0.44 5.94 0.31 7.34e-9 Sudden cardiac arrest; LUSC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg02275930 chr1:2372054 NA -0.52 -7.81 -0.39 7.37e-14 Non-obstructive azoospermia; LUSC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg25809561 chr17:30822961 MYO1D 0.55 9.51 0.46 3.89e-19 Schizophrenia; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg06873352 chr17:61820015 STRADA 0.69 12.61 0.57 4.56e-30 Prudent dietary pattern; LUSC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg17264618 chr3:40429014 ENTPD3 0.3 6.27 0.32 1.11e-9 Renal cell carcinoma; LUSC cis rs4888262 0.526 rs7201105 chr16:74590603 A/G cg01733217 chr16:74700730 RFWD3 0.75 12.24 0.56 1.05e-28 Testicular germ cell tumor; LUSC cis rs975210 0.556 rs2291986 chr15:70368432 C/T cg01666796 chr15:70364327 TLE3 0.43 5.96 0.31 6.49e-9 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; LUSC trans rs7178375 1.000 rs12907055 chr15:31204294 C/G cg04373760 chr16:53404718 NA 0.65 8.79 0.43 7.82e-17 Hypertriglyceridemia; LUSC cis rs10193935 0.901 rs6544533 chr2:42516372 G/C cg27598129 chr2:42591480 NA -0.57 -7.83 -0.39 6.33e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg17971929 chr21:40555470 PSMG1 -0.6 -10.0 -0.48 8.96e-21 Cognitive function; LUSC cis rs12760731 0.565 rs77024410 chr1:178164121 A/C cg00404053 chr1:178313656 RASAL2 0.66 6.82 0.35 4.26e-11 Obesity-related traits; LUSC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg03388025 chr16:89894329 SPIRE2 0.34 6.84 0.35 3.81e-11 Vitiligo; LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg10802521 chr3:52805072 NEK4 -0.57 -9.17 -0.45 5.16e-18 Bipolar disorder; LUSC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.68 0.34 9.88e-11 Systemic lupus erythematosus; LUSC cis rs7408868 1.000 rs7247835 chr19:15262844 A/G cg14696996 chr19:15285081 NOTCH3 0.98 9.06 0.44 1.11e-17 Pulse pressure; LUSC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 6.17 0.32 1.95e-9 Mean platelet volume; LUSC cis rs9837602 1.000 rs2291494 chr3:99781805 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.16 0.32 2.03e-9 Breast cancer; LUSC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs7608623 0.773 rs1862900 chr2:23922315 C/A cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC cis rs11758351 1.000 rs78012445 chr6:26195080 G/C cg23601095 chr6:26197514 HIST1H3D 0.71 7.35 0.37 1.57e-12 Gout;Renal underexcretion gout; LUSC cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg14416269 chr4:6271139 WFS1 0.45 8.5 0.42 6.38e-16 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg09033563 chr22:24373618 LOC391322 -0.49 -6.81 -0.35 4.54e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs877282 0.838 rs34778553 chr10:796865 T/C cg22713356 chr15:30763199 NA 1.08 15.86 0.66 1.23e-42 Uric acid levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03352409 chr22:21336370 LZTR1 0.49 6.76 0.35 6.16e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs72615157 0.539 rs72615159 chr7:99674286 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.47 6.63 0.34 1.37e-10 Lung function (FEV1/FVC); LUSC cis rs1949733 0.523 rs16842560 chr4:8544238 G/A cg11789530 chr4:8429930 ACOX3 -0.41 -6.11 -0.32 2.78e-9 Response to antineoplastic agents; LUSC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.53 -9.26 -0.45 2.52e-18 Menopause (age at onset); LUSC cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg01689657 chr7:91764605 CYP51A1 0.32 5.84 0.3 1.25e-8 Breast cancer; LUSC trans rs4596713 0.508 rs4076287 chr9:71755333 A/G cg25283916 chr1:242222868 NA -0.32 -6.6 -0.34 1.64e-10 Headache; LUSC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg18827107 chr12:86230957 RASSF9 -0.46 -6.96 -0.36 1.81e-11 Major depressive disorder; LUSC cis rs7804356 1.000 rs73067456 chr7:26852998 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs11864453 0.679 rs2303285 chr16:72124495 A/C cg01557791 chr16:72042693 DHODH -0.46 -6.83 -0.35 4e-11 Fibrinogen levels; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.26 0.45 2.6e-18 Prudent dietary pattern; LUSC cis rs13082711 0.911 rs7650165 chr3:27462440 C/T cg02860705 chr3:27208620 NA 0.5 8.51 0.42 6.09e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs28735056 0.660 rs12454454 chr18:77674634 C/T cg20368463 chr18:77673604 PQLC1 -0.74 -11.65 -0.54 1.44e-26 Schizophrenia; LUSC cis rs2235649 0.592 rs8051883 chr16:1958978 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.47 -5.69 -0.3 2.76e-8 Blood metabolite levels; LUSC cis rs2692947 0.770 rs72823920 chr2:96430876 G/A cg22654517 chr2:96458247 NA 0.37 7.01 0.36 1.36e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg22903471 chr2:27725779 GCKR -0.4 -6.84 -0.35 3.67e-11 Total body bone mineral density; LUSC cis rs6681460 0.966 rs10789214 chr1:67146817 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.9 0.44 3.53e-17 Presence of antiphospholipid antibodies; LUSC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg25427524 chr10:38739819 LOC399744 -0.72 -13.39 -0.59 5.04e-33 Extrinsic epigenetic age acceleration; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg08470875 chr2:26401718 FAM59B -0.69 -9.37 -0.46 1.16e-18 Gut microbiome composition (summer); LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg23758822 chr17:41437982 NA 1.03 19.24 0.72 4.93e-56 Menopause (age at onset); LUSC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg11344533 chr11:111475393 SIK2 -0.46 -6.35 -0.33 7.08e-10 Primary sclerosing cholangitis; LUSC cis rs4948275 0.550 rs10994742 chr10:63132240 A/T cg26296364 chr10:63212206 TMEM26 -0.36 -5.82 -0.3 1.35e-8 Night sleep phenotypes; LUSC cis rs10751667 0.643 rs10751666 chr11:941933 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.42 0.33 4.72e-10 Alzheimer's disease (late onset); LUSC trans rs61931739 0.500 rs7309931 chr12:34483471 A/C cg13010199 chr12:38710504 ALG10B 0.58 9.16 0.45 5.51e-18 Morning vs. evening chronotype; LUSC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC cis rs908922 0.676 rs1572533 chr1:152509742 T/C cg20991723 chr1:152506922 NA 0.51 9.77 0.47 5.58e-20 Hair morphology; LUSC cis rs714027 1.000 rs4823074 chr22:30512478 G/A cg11564601 chr22:30592435 NA -0.37 -6.78 -0.35 5.4e-11 Lymphocyte counts; LUSC cis rs5758511 0.573 rs2284082 chr22:42240797 C/T cg03131358 chr22:42195972 CCDC134 -0.32 -5.74 -0.3 2.12e-8 Birth weight; LUSC cis rs77633900 0.772 rs2460161 chr15:76640430 C/T cg21673338 chr15:77095150 SCAPER -0.69 -5.97 -0.31 5.98e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg04025307 chr7:1156635 C7orf50 0.37 5.69 0.3 2.73e-8 Longevity;Endometriosis; LUSC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -10.29 -0.49 9.32e-22 Menarche (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06366937 chr1:74663927 TNNI3K;FPGT;LRRIQ3 0.65 6.04 0.31 4.21e-9 Cognitive performance; LUSC cis rs67478160 0.634 rs7141928 chr14:104219949 C/T cg08213375 chr14:104286397 PPP1R13B 0.45 8.62 0.43 2.77e-16 Schizophrenia; LUSC cis rs908922 0.676 rs4845443 chr1:152507156 C/T cg20991723 chr1:152506922 NA 0.53 10.22 0.49 1.57e-21 Hair morphology; LUSC cis rs807669 0.900 rs712964 chr22:19156117 T/C cg02655711 chr22:19163373 SLC25A1 0.78 14.78 0.63 2.29e-38 Metabolite levels; LUSC cis rs9326248 0.539 rs10892065 chr11:116897024 T/C cg11861562 chr11:117069780 TAGLN 0.32 6.2 0.32 1.64e-9 Blood protein levels; LUSC cis rs34779708 0.931 rs12771399 chr10:35452377 C/T cg04310649 chr10:35416472 CREM -0.42 -6.46 -0.33 3.77e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg27165867 chr14:105738592 BRF1 -0.5 -7.39 -0.37 1.19e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs8141529 0.509 rs12628211 chr22:29239250 T/C cg02153584 chr22:29168773 CCDC117 0.55 8.29 0.41 2.87e-15 Lymphocyte counts; LUSC cis rs16912285 0.688 rs12284649 chr11:24316260 T/A ch.11.24196551F chr11:24239977 NA 0.85 8.88 0.44 4.15e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg00310523 chr12:86230176 RASSF9 0.45 8.28 0.41 2.97e-15 Major depressive disorder; LUSC cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg23711669 chr6:146136114 FBXO30 0.86 15.54 0.65 2.4e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs1790761 0.658 rs666328 chr11:67335538 G/A cg14500267 chr11:67383377 NA 0.34 6.51 0.34 2.75e-10 Mean corpuscular volume; LUSC cis rs12681287 0.547 rs10087788 chr8:87544174 G/A cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs11264799 0.765 rs12128597 chr1:157623603 C/T cg18268488 chr1:157545234 FCRL4 0.33 5.74 0.3 2.13e-8 IgA nephropathy; LUSC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg11764359 chr7:65958608 NA 0.68 10.68 0.5 4.27e-23 Aortic root size; LUSC cis rs2486288 0.656 rs12440356 chr15:45567529 T/C cg09092052 chr15:45571596 NA -0.48 -6.67 -0.34 1.04e-10 Glomerular filtration rate; LUSC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.67 8.9 0.44 3.56e-17 Multiple sclerosis; LUSC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg04267008 chr7:1944627 MAD1L1 -0.52 -7.86 -0.4 5.32e-14 Bipolar disorder and schizophrenia; LUSC cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg08999081 chr20:33150536 PIGU -0.51 -10.37 -0.49 5.03e-22 Glomerular filtration rate (creatinine); LUSC cis rs9467773 0.869 rs742090 chr6:26415637 A/C cg09904177 chr6:26538194 HMGN4 -0.68 -11.36 -0.53 1.62e-25 Intelligence (multi-trait analysis); LUSC cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg05985134 chr18:33552581 C18orf21 0.52 7.25 0.37 2.99e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs12760731 0.565 rs12034657 chr1:178099354 A/C cg00404053 chr1:178313656 RASAL2 -0.63 -6.54 -0.34 2.28e-10 Obesity-related traits; LUSC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg25554036 chr4:6271136 WFS1 0.46 7.0 0.36 1.42e-11 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1997103 1.000 rs2177804 chr7:55410302 G/A cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7617773 0.779 rs1045482 chr3:48312229 A/G cg20734569 chr3:48348370 SPINK8 -0.44 -7.69 -0.39 1.68e-13 Coronary artery disease; LUSC cis rs2760061 0.819 rs708120 chr1:228207651 G/C cg04850211 chr1:228464232 OBSCN -0.32 -5.7 -0.3 2.67e-8 Diastolic blood pressure; LUSC cis rs7098414 0.511 rs12262228 chr10:82160425 C/T cg01528321 chr10:82214614 TSPAN14 0.62 9.3 0.45 1.9e-18 Post bronchodilator FEV1; LUSC cis rs709400 0.628 rs6575983 chr14:103869849 C/G cg10523860 chr14:103875565 MARK3 -0.36 -6.18 -0.32 1.89e-9 Body mass index; LUSC cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg27279351 chr12:120934652 DYNLL1 -0.61 -8.13 -0.41 8.28e-15 High light scatter reticulocyte count; LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 12.95 0.58 2.37e-31 Alzheimer's disease; LUSC cis rs9815354 1.000 rs2128835 chr3:41862873 A/G cg03022575 chr3:42003672 ULK4 0.58 6.54 0.34 2.3e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs16937 0.711 rs6682400 chr1:205173519 T/G cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg16339924 chr4:17578868 LAP3 -0.57 -8.44 -0.42 9.44e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17059575 chr17:33307583 LIG3 -0.46 -6.9 -0.35 2.62e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7851660 0.844 rs12342417 chr9:100639065 G/A cg13688889 chr9:100608707 NA -0.54 -8.44 -0.42 9.99e-16 Strep throat; LUSC cis rs72781680 0.898 rs72786270 chr2:24059049 G/A cg08917208 chr2:24149416 ATAD2B 0.84 9.31 0.45 1.77e-18 Lymphocyte counts; LUSC cis rs35264875 0.898 rs72928701 chr11:68861564 C/T cg02660097 chr11:68866761 NA 0.43 6.14 0.32 2.36e-9 Blond vs. brown hair color; LUSC cis rs10504229 0.679 rs72649131 chr8:58054288 G/T cg11062466 chr8:58055876 NA 0.51 6.7 0.34 8.73e-11 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 31.79 0.87 5.08e-103 Chronic sinus infection; LUSC cis rs75920871 0.588 rs1871756 chr11:116953645 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.54 -6.9 -0.35 2.65e-11 Subjective well-being; LUSC cis rs13108904 0.870 rs2335855 chr4:1237968 T/C cg13395646 chr4:1353034 KIAA1530 -0.59 -9.26 -0.45 2.58e-18 Obesity-related traits; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.2e-26 Prudent dietary pattern; LUSC cis rs9362426 0.708 rs9342112 chr6:88092491 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.37 6.03 0.31 4.36e-9 Depressive episodes in bipolar disorder; LUSC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg27494647 chr7:150038898 RARRES2 0.48 7.29 0.37 2.23e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg01028140 chr2:1542097 TPO -0.52 -8.45 -0.42 9.07e-16 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs8056893 0.569 rs9937244 chr16:68307559 T/A cg02226672 chr16:68398533 SMPD3 0.29 5.66 0.3 3.27e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg02153584 chr22:29168773 CCDC117 -0.57 -8.58 -0.43 3.58e-16 Lymphocyte counts; LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg11062466 chr8:58055876 NA 0.65 8.55 0.42 4.36e-16 Developmental language disorder (linguistic errors); LUSC cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg04727924 chr7:799746 HEATR2 -0.55 -6.71 -0.34 8.16e-11 Cerebrospinal P-tau181p levels; LUSC cis rs12530845 0.887 rs6948382 chr7:135323576 G/A cg23117316 chr7:135346802 PL-5283 -0.57 -9.2 -0.45 3.85e-18 Red blood cell traits; LUSC cis rs10028773 0.546 rs13117947 chr4:120257060 A/G cg09307838 chr4:120376055 NA 0.5 7.61 0.38 2.91e-13 Educational attainment; LUSC cis rs6430585 0.697 rs7607174 chr2:136513670 T/A cg07169764 chr2:136633963 MCM6 1.18 17.49 0.69 4.22e-49 Corneal structure; LUSC cis rs7119 0.604 rs2271397 chr15:77907775 T/C cg27398640 chr15:77910606 LINGO1 0.38 8.91 0.44 3.25e-17 Type 2 diabetes; LUSC cis rs9341808 0.539 rs2490253 chr6:80895870 T/C cg08355045 chr6:80787529 NA 0.47 8.16 0.41 6.82e-15 Sitting height ratio; LUSC cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.93 0.66 6.79e-43 Bladder cancer; LUSC cis rs314370 0.855 rs76181418 chr7:100494960 G/T cg10426581 chr7:100472382 SRRT 0.86 12.37 0.56 3.44e-29 Resting heart rate; LUSC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg00509249 chr6:109615579 CCDC162 -0.33 -5.9 -0.31 9.11e-9 Reticulocyte fraction of red cells; LUSC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg20243544 chr17:37824526 PNMT -0.45 -5.69 -0.3 2.81e-8 Glomerular filtration rate (creatinine); LUSC cis rs73206853 0.841 rs7959516 chr12:110622224 A/C cg12870014 chr12:110450643 ANKRD13A 0.56 5.67 0.3 3.15e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05670192 chr19:56154902 ZNF581 -0.39 -6.34 -0.33 7.6e-10 Electrocardiographic conduction measures; LUSC cis rs1878931 0.501 rs9635547 chr16:3416664 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.69 11.15 0.52 9.34e-25 Body mass index (adult); LUSC cis rs2115536 0.692 rs6495450 chr15:80162499 C/A cg00225070 chr15:80189496 MTHFS 0.42 6.09 0.32 3.07e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.74 -0.35 7.04e-11 Total body bone mineral density; LUSC cis rs77633900 0.892 rs7180257 chr15:76632907 A/G cg21673338 chr15:77095150 SCAPER 0.63 6.0 0.31 5.07e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2742417 1.000 rs2673039 chr3:45748435 A/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.48 -0.38 6.41e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1577917 1.000 rs955227 chr6:86651032 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.92 -0.35 2.39e-11 Response to antipsychotic treatment; LUSC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs9283706 0.608 rs10053537 chr5:66332543 T/C cg11590213 chr5:66331682 MAST4 0.45 6.76 0.35 6.28e-11 Coronary artery disease; LUSC cis rs11250098 0.600 rs4240671 chr8:10767748 A/G cg27411982 chr8:10470053 RP1L1 0.44 6.8 0.35 4.82e-11 Morning vs. evening chronotype; LUSC cis rs735539 0.718 rs7985552 chr13:21280738 A/T cg04906043 chr13:21280425 IL17D 0.4 6.74 0.35 6.85e-11 Dental caries; LUSC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg04518342 chr5:131593106 PDLIM4 -0.33 -5.95 -0.31 6.83e-9 Breast cancer;Mosquito bite size; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg26338869 chr17:61819248 STRADA 0.41 5.81 0.3 1.47e-8 Prudent dietary pattern; LUSC cis rs8072100 0.512 rs3809863 chr17:45385012 C/T cg08085267 chr17:45401833 C17orf57 -0.64 -10.71 -0.51 3.26e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1729951 0.546 rs12054219 chr3:136677472 G/A cg21827317 chr3:136751795 NA 0.39 6.9 0.35 2.6e-11 Neuroticism; LUSC cis rs2273669 0.667 rs6651000 chr6:109281411 G/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.76 -0.3 1.94e-8 Prostate cancer; LUSC cis rs34779708 0.966 rs4934540 chr10:35474699 T/C cg04310649 chr10:35416472 CREM -0.42 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg06064525 chr11:970664 AP2A2 -0.37 -7.29 -0.37 2.23e-12 Alzheimer's disease (late onset); LUSC cis rs6714788 0.503 rs2309748 chr2:100681449 A/T cg07810366 chr2:100720526 AFF3 -0.39 -6.18 -0.32 1.85e-9 Intelligence (multi-trait analysis); LUSC cis rs4730250 0.554 rs112665932 chr7:106916121 A/G cg02696742 chr7:106810147 HBP1 -0.56 -7.44 -0.38 8.44e-13 Osteoarthritis; LUSC cis rs10986311 0.862 rs1408096 chr9:127107143 C/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.39 6.18 0.32 1.91e-9 Vitiligo; LUSC cis rs11030122 0.702 rs10835406 chr11:3992954 G/T cg18678763 chr11:4115507 RRM1 0.45 5.9 0.31 9.07e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs11785693 0.817 rs62491199 chr8:4997878 G/A cg26367366 chr8:4980734 NA 0.76 8.68 0.43 1.81e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2979489 0.891 rs4285443 chr8:30327317 A/G cg26383811 chr8:30366931 RBPMS -0.49 -7.91 -0.4 3.81e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -11.98 -0.55 9.35e-28 Platelet count; LUSC cis rs7246967 0.611 rs4933024 chr19:22867063 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC trans rs7313075 0.639 rs34804904 chr12:102586795 A/C cg03720887 chr8:101963845 YWHAZ 0.62 6.15 0.32 2.27e-9 Height; LUSC cis rs17621444 0.522 rs1029154 chr10:121772614 G/T cg02041677 chr10:121771263 NA -0.34 -6.47 -0.33 3.53e-10 IgG glycosylation; LUSC cis rs7481584 0.624 rs377765 chr11:3046298 C/T cg08508325 chr11:3079039 CARS 0.37 8.28 0.41 2.98e-15 Calcium levels; LUSC trans rs2797160 0.935 rs60515555 chr6:126000638 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.59 -0.34 1.71e-10 Endometrial cancer; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg04234412 chr22:24373322 LOC391322 -0.88 -15.71 -0.65 4.88e-42 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12891047 1.000 rs2295108 chr14:68250622 T/C cg20999565 chr14:68265668 ZFYVE26 -0.39 -6.12 -0.32 2.58e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1728785 1.000 rs12925177 chr16:68569645 A/G cg02972257 chr16:68554789 NA 0.49 6.47 0.33 3.57e-10 Ulcerative colitis; LUSC cis rs9517320 0.534 rs3825430 chr13:99129653 C/T cg07423050 chr13:99094983 FARP1 -0.54 -9.69 -0.47 9.98e-20 Longevity; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00414058 chr16:9185479 C16orf72 0.69 6.02 0.31 4.56e-9 Cognitive performance; LUSC cis rs12310956 0.532 rs10844719 chr12:33987714 A/G cg06521331 chr12:34319734 NA -0.47 -7.56 -0.38 3.99e-13 Morning vs. evening chronotype; LUSC cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg09184832 chr6:79620586 NA -0.42 -6.79 -0.35 5.28e-11 Intelligence (multi-trait analysis); LUSC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg04317338 chr11:64019027 PLCB3 0.69 7.93 0.4 3.42e-14 Mean platelet volume; LUSC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.76 0.35 5.99e-11 Intelligence (multi-trait analysis); LUSC cis rs7712401 0.601 rs173480 chr5:122254131 C/A cg19077854 chr5:122220652 SNX24 0.41 8.94 0.44 2.67e-17 Mean platelet volume; LUSC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.74 0.35 6.91e-11 Menarche (age at onset); LUSC cis rs738322 0.810 rs4820323 chr22:38599767 C/G cg25457927 chr22:38595422 NA 0.48 10.07 0.48 5.46e-21 Cutaneous nevi; LUSC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg04267008 chr7:1944627 MAD1L1 -0.52 -7.54 -0.38 4.37e-13 Schizophrenia; LUSC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2625529 0.668 rs12591338 chr15:72556847 T/A cg16672083 chr15:72433130 SENP8 -0.49 -7.2 -0.37 4.02e-12 Red blood cell count; LUSC cis rs2204008 0.837 rs2892296 chr12:37969785 C/T cg13010199 chr12:38710504 ALG10B -0.62 -9.61 -0.47 1.87e-19 Bladder cancer; LUSC cis rs7584330 0.910 rs6713555 chr2:238398182 A/G cg14458575 chr2:238380390 NA -0.69 -12.19 -0.55 1.6e-28 Prostate cancer; LUSC trans rs2392780 0.536 rs590574 chr8:128335715 A/G cg10897648 chr18:56338258 MALT1 -0.41 -6.21 -0.32 1.56e-9 Breast cancer (early onset); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg07138452 chr17:17141020 FLCN -0.47 -6.03 -0.31 4.24e-9 Height; LUSC cis rs1595825 0.891 rs7585709 chr2:198883682 C/T cg10547527 chr2:198650123 BOLL -0.52 -6.3 -0.33 9.56e-10 Ulcerative colitis; LUSC cis rs4363385 0.647 rs4845513 chr1:152998066 T/C cg00922841 chr1:152955080 SPRR1A -0.42 -6.95 -0.36 1.92e-11 Inflammatory skin disease; LUSC cis rs920590 0.717 rs62496675 chr8:19635733 A/T cg03894339 chr8:19674705 INTS10 0.42 5.66 0.3 3.18e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg17911788 chr17:44343683 NA 0.3 5.82 0.3 1.35e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg03647239 chr10:116582469 FAM160B1 0.47 7.59 0.38 3.26e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg17366294 chr4:99064904 C4orf37 0.54 9.49 0.46 4.71e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs12421382 0.543 rs10890996 chr11:109328421 A/G cg16359550 chr11:109292809 C11orf87 -0.47 -7.94 -0.4 3.16e-14 Schizophrenia; LUSC cis rs950169 0.649 rs12911612 chr15:84691014 T/C cg12863693 chr15:85201151 NMB 0.37 6.88 0.35 2.97e-11 Schizophrenia; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg00024416 chr22:24240387 NA -0.32 -5.9 -0.31 9.02e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg17515076 chr17:73810948 UNK 0.35 5.84 0.3 1.22e-8 White matter hyperintensity burden; LUSC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg21724239 chr8:58056113 NA 0.66 7.4 0.38 1.14e-12 Developmental language disorder (linguistic errors); LUSC cis rs62400317 0.826 rs17288327 chr6:45349877 A/G cg20913747 chr6:44695427 NA -0.47 -7.68 -0.39 1.82e-13 Total body bone mineral density; LUSC cis rs4595586 0.525 rs10506132 chr12:39404599 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.33 0.33 8.1e-10 Morning vs. evening chronotype; LUSC cis rs7100689 0.753 rs2185426 chr10:82120887 G/A cg01528321 chr10:82214614 TSPAN14 1.03 15.99 0.66 3.98e-43 Post bronchodilator FEV1; LUSC cis rs9443189 0.570 rs567903 chr6:76327851 C/T cg01950844 chr6:76311363 SENP6 0.68 6.69 0.34 9.24e-11 Prostate cancer; LUSC cis rs6076065 0.723 rs6137949 chr20:23418217 T/G cg11657817 chr20:23433608 CST11 0.41 7.28 0.37 2.37e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg01579765 chr21:45077557 HSF2BP -0.5 -10.53 -0.5 1.38e-22 Mean corpuscular volume; LUSC cis rs1729951 0.575 rs12494558 chr3:136678781 C/G cg21827317 chr3:136751795 NA 0.39 6.95 0.36 1.98e-11 Neuroticism; LUSC cis rs12956009 0.583 rs11662486 chr18:44868325 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.35 0.33 7.19e-10 Educational attainment (years of education); LUSC cis rs7927592 0.913 rs4316515 chr11:68308840 A/T cg16797656 chr11:68205561 LRP5 -0.39 -6.37 -0.33 6.36e-10 Total body bone mineral density; LUSC cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg16339924 chr4:17578868 LAP3 0.61 9.34 0.46 1.38e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1348850 0.632 rs13008833 chr2:178514439 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.92 0.31 7.84e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs77741769 0.507 rs11065264 chr12:121218380 T/G cg02419362 chr12:121203948 SPPL3 0.46 8.61 0.43 2.9e-16 Mean corpuscular volume; LUSC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg10556349 chr10:835070 NA 0.56 6.23 0.32 1.41e-9 Eosinophil percentage of granulocytes; LUSC cis rs9649213 0.614 rs12539761 chr7:98013839 C/T cg08684580 chr7:98029266 BAIAP2L1 0.39 5.85 0.3 1.16e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -9.68 -0.47 1.03e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs10435719 0.764 rs10103485 chr8:11787563 C/T cg00405596 chr8:11794950 NA 0.36 5.98 0.31 5.83e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7089973 0.624 rs10885614 chr10:116609098 C/T cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25764190 chr19:44037015 ZNF575 0.39 6.06 0.31 3.64e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs12367572 0.663 rs4561266 chr12:45415763 C/T cg04608330 chr12:45269318 NELL2 -0.39 -5.87 -0.31 1.06e-8 Gut microbiome composition (summer); LUSC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg13206674 chr6:150067644 NUP43 0.57 9.09 0.45 9.1e-18 Lung cancer; LUSC cis rs4268898 0.560 rs78711174 chr2:24496531 G/A cg06627628 chr2:24431161 ITSN2 -0.85 -12.22 -0.56 1.24e-28 Asthma; LUSC trans rs6601327 0.606 rs7006985 chr8:9564437 A/G cg15556689 chr8:8085844 FLJ10661 -0.43 -6.16 -0.32 2.04e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg23630131 chr7:65973040 NA -0.21 -5.83 -0.3 1.33e-8 Aortic root size; LUSC cis rs9318086 0.712 rs3794339 chr13:24434065 A/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.41 6.19 0.32 1.75e-9 Myopia (pathological); LUSC trans rs1005277 0.579 rs2505196 chr10:38393563 G/A cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs911555 0.755 rs975892 chr14:103883349 A/T cg09975044 chr14:104007538 NA 0.37 5.84 0.3 1.27e-8 Intelligence (multi-trait analysis); LUSC trans rs6951245 0.744 rs10275401 chr7:1213943 A/C cg13565492 chr6:43139072 SRF -0.56 -6.21 -0.32 1.57e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg07703079 chr11:430292 ANO9 0.6 6.54 0.34 2.28e-10 Body mass index; LUSC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs11971779 0.715 rs6467856 chr7:139127299 A/C cg07862535 chr7:139043722 LUC7L2 0.57 7.14 0.36 6.02e-12 Diisocyanate-induced asthma; LUSC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg11764359 chr7:65958608 NA 0.61 9.19 0.45 4.15e-18 Aortic root size; LUSC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg09826364 chr7:158789723 NA -0.38 -5.91 -0.31 8.3e-9 Facial morphology (factor 20); LUSC cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg18681998 chr4:17616180 MED28 0.84 14.92 0.63 6.27e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs977987 0.778 rs62059846 chr16:75430809 T/A cg03315344 chr16:75512273 CHST6 0.48 9.12 0.45 6.97e-18 Dupuytren's disease; LUSC cis rs7512552 0.839 rs17596326 chr1:150433819 A/G cg15654264 chr1:150340011 RPRD2 0.65 10.79 0.51 1.71e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.47e-24 Aortic root size; LUSC trans rs13011075 0.844 rs10174380 chr2:68596469 C/T cg14221825 chr19:46271408 SIX5 0.43 6.18 0.32 1.82e-9 Mean corpuscular volume; LUSC cis rs1030877 0.924 rs2250658 chr2:105889683 C/T cg02079111 chr2:105885981 TGFBRAP1 0.78 14.96 0.63 4.33e-39 Obesity-related traits; LUSC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg15145296 chr3:125709740 NA -0.56 -6.62 -0.34 1.44e-10 Blood pressure (smoking interaction); LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg14646974 chr10:38645378 HSD17B7P2 -0.46 -6.52 -0.34 2.66e-10 Breast cancer; LUSC cis rs59918340 0.764 rs753779 chr8:142228809 T/C cg23750338 chr8:142222470 SLC45A4 0.58 11.3 0.53 2.76e-25 Immature fraction of reticulocytes; LUSC cis rs6693567 0.516 rs3850844 chr1:150413940 G/T cg15654264 chr1:150340011 RPRD2 0.44 7.11 0.36 7.28e-12 Migraine; LUSC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg27266027 chr21:40555129 PSMG1 -0.41 -5.97 -0.31 5.92e-9 Cognitive function; LUSC cis rs9309473 1.000 rs10169714 chr2:73808773 T/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.41 -0.33 4.86e-10 Metabolite levels; LUSC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg06212747 chr3:49208901 KLHDC8B 0.43 5.76 0.3 1.94e-8 Parkinson's disease; LUSC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg03517284 chr6:25882590 NA -0.38 -6.8 -0.35 4.89e-11 Height; LUSC cis rs1372520 0.873 rs2737026 chr4:90779823 A/G cg14346243 chr4:90757452 SNCA -0.4 -5.78 -0.3 1.72e-8 Neuroticism; LUSC cis rs734999 0.505 rs60687045 chr1:2539603 G/A cg18932078 chr1:2524107 MMEL1 0.32 7.12 0.36 6.68e-12 Ulcerative colitis; LUSC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg06850241 chr22:41845214 NA 0.34 6.06 0.31 3.71e-9 Vitiligo; LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.26 0.37 2.8e-12 Platelet count; LUSC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.97 0.44 2.17e-17 Menopause (age at onset); LUSC trans rs10511400 0.618 rs2319542 chr3:119905641 A/G cg02809009 chr19:50354510 PTOV1 0.69 6.02 0.31 4.71e-9 Economic and political preferences (feminism/equality); LUSC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg02117656 chr17:79614917 TSPAN10 0.31 5.76 0.3 1.88e-8 Eye color traits; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg13395646 chr4:1353034 KIAA1530 0.63 10.34 0.49 6.46e-22 Obesity-related traits; LUSC cis rs9399135 0.967 rs6923765 chr6:135335176 C/G cg22676075 chr6:135203613 NA -0.46 -7.26 -0.37 2.74e-12 Red blood cell count; LUSC trans rs6601327 0.571 rs7838571 chr8:9647796 A/G cg06636001 chr8:8085503 FLJ10661 0.51 7.56 0.38 3.91e-13 Multiple myeloma (hyperdiploidy); LUSC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg04455712 chr21:45112962 RRP1B 0.43 8.0 0.4 2e-14 Mean corpuscular volume; LUSC cis rs6845621 0.901 rs1079811 chr4:18925941 G/A cg12196642 chr4:18937545 NA -0.33 -6.09 -0.32 3.08e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.13 0.45 6.88e-18 Hip circumference adjusted for BMI; LUSC cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg03213289 chr20:61660250 NA 0.66 12.81 0.57 7.61e-31 Prostate cancer (SNP x SNP interaction); LUSC cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg24296786 chr1:45957014 TESK2 -0.51 -7.66 -0.39 2.01e-13 High light scatter reticulocyte count; LUSC cis rs6940638 1.000 rs6940638 chr6:27046250 A/G cg09904177 chr6:26538194 HMGN4 -0.5 -5.92 -0.31 7.83e-9 Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg18681998 chr4:17616180 MED28 0.85 15.8 0.65 2.14e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6429082 0.702 rs10802797 chr1:235705673 A/G cg26050004 chr1:235667680 B3GALNT2 0.46 6.57 0.34 1.97e-10 Adiposity; LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg03579872 chr1:53393473 SCP2 -0.4 -5.93 -0.31 7.36e-9 Monocyte count; LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC trans rs7980799 0.711 rs12319055 chr12:33626509 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.32 -0.33 8.5e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs9467773 0.526 rs3734536 chr6:26365346 C/G cg05738196 chr6:26577821 NA -0.45 -6.94 -0.36 2.01e-11 Intelligence (multi-trait analysis); LUSC cis rs3916 0.794 rs3021337 chr12:121163261 C/T cg21892295 chr12:121157589 UNC119B -0.4 -6.62 -0.34 1.4e-10 Urinary metabolites (H-NMR features); LUSC cis rs7264396 0.887 rs1570841 chr20:34048161 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.61 -0.34 1.5e-10 Total cholesterol levels; LUSC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.38 0.33 5.82e-10 Hip circumference adjusted for BMI; LUSC cis rs7100689 0.577 rs7901663 chr10:82153488 C/G cg00277334 chr10:82204260 NA -0.48 -7.11 -0.36 7e-12 Post bronchodilator FEV1; LUSC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg21153622 chr11:89784906 NA -0.46 -7.16 -0.36 5.31e-12 Coronary artery disease; LUSC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg11266682 chr4:10021025 SLC2A9 -0.54 -9.49 -0.46 4.53e-19 Bone mineral density; LUSC cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg21535247 chr6:8435926 SLC35B3 -0.57 -8.45 -0.42 9.16e-16 Motion sickness; LUSC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg25036284 chr2:26402008 FAM59B -0.69 -9.72 -0.47 7.82e-20 Gut microbiome composition (summer); LUSC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg19230755 chr7:65878503 NA 0.42 5.89 0.31 9.35e-9 Aortic root size; LUSC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs9479482 0.789 rs12204988 chr6:150339315 T/G cg07578070 chr6:150326732 RAET1K 0.41 6.37 0.33 6.13e-10 Alopecia areata; LUSC cis rs7524258 0.868 rs10779678 chr1:7300573 A/G cg07173049 chr1:7289937 CAMTA1 0.34 7.03 0.36 1.19e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7200543 1.000 rs16966953 chr16:15135854 A/G cg03427771 chr16:15082598 PDXDC1 -0.42 -5.89 -0.31 9.58e-9 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs9790314 1.000 rs1478565 chr3:161027464 C/T cg04691961 chr3:161091175 C3orf57 -0.35 -5.99 -0.31 5.34e-9 Morning vs. evening chronotype; LUSC cis rs2289328 1.000 rs2289328 chr15:40705417 G/A cg13931752 chr15:40660718 DISP2 0.46 6.11 0.32 2.83e-9 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs17685 0.672 rs1639623 chr7:75707951 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.62 -0.38 2.64e-13 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg16407604 chr1:40724172 ZMPSTE24 0.39 6.24 0.32 1.36e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.38 -0.56 3.13e-29 Alzheimer's disease; LUSC cis rs3892630 0.588 rs1976501 chr19:33208155 C/T cg22980127 chr19:33182716 NUDT19 0.9 12.93 0.58 2.68e-31 Red blood cell traits; LUSC cis rs2692947 0.667 rs4144055 chr2:96647856 G/T cg23100626 chr2:96804247 ASTL 0.26 6.33 0.33 8.04e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg11062466 chr8:58055876 NA 0.49 6.3 0.33 9.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11644478 chr21:40555479 PSMG1 0.96 19.16 0.72 1.04e-55 Cognitive function; LUSC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg20790798 chr5:1857306 NA -0.51 -8.67 -0.43 1.94e-16 Cardiovascular disease risk factors; LUSC trans rs34421088 0.560 rs2245357 chr8:11399484 A/T cg08975724 chr8:8085496 FLJ10661 -0.52 -7.86 -0.4 5.16e-14 Neuroticism; LUSC cis rs4144743 0.641 rs67696888 chr17:45355116 A/G cg18085866 chr17:45331354 ITGB3 -0.64 -6.33 -0.33 7.69e-10 Body mass index; LUSC cis rs28830936 1.000 rs17678767 chr15:42096422 C/G cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.69 -0.3 2.81e-8 Diastolic blood pressure; LUSC cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg04455712 chr21:45112962 RRP1B 0.44 8.56 0.42 4.19e-16 Mean corpuscular volume; LUSC cis rs1775715 0.835 rs1419169 chr10:32257204 C/G cg18675610 chr10:32216311 ARHGAP12 0.28 5.93 0.31 7.38e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10752881 0.740 rs1889307 chr1:183049389 T/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.5 0.5 1.75e-22 Colorectal cancer; LUSC cis rs96067 0.711 rs272827 chr1:36627191 C/T cg24686825 chr1:36642396 MAP7D1 0.7 10.88 0.51 8.09e-24 Corneal structure; LUSC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg06618935 chr21:46677482 NA -0.39 -7.81 -0.39 7.53e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg18479299 chr3:125709523 NA -0.52 -5.92 -0.31 7.97e-9 Blood pressure (smoking interaction); LUSC cis rs734999 0.588 rs4648653 chr1:2535895 C/T cg18854424 chr1:2615690 NA 0.49 9.84 0.47 3.06e-20 Ulcerative colitis; LUSC cis rs67696533 0.711 rs6119897 chr20:31145415 A/G cg13636640 chr20:31349939 DNMT3B -0.49 -6.72 -0.35 7.72e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs1814175 0.712 rs9665784 chr11:50030617 C/T cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs950027 0.787 rs2433616 chr15:45728599 A/G cg26924012 chr15:45694286 SPATA5L1 0.73 11.02 0.52 2.74e-24 Response to fenofibrate (adiponectin levels); LUSC cis rs796364 0.806 rs10931890 chr2:201102055 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.37 -0.42 1.66e-15 Schizophrenia; LUSC cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg25208724 chr1:156163844 SLC25A44 1.03 22.65 0.78 1.85e-69 Testicular germ cell tumor; LUSC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg18230493 chr5:56204884 C5orf35 -0.88 -13.22 -0.59 2.3e-32 Initial pursuit acceleration; LUSC cis rs868036 0.645 rs4492996 chr15:68113240 A/G cg05925327 chr15:68127851 NA -0.38 -5.95 -0.31 6.96e-9 Restless legs syndrome; LUSC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11890956 chr21:40555474 PSMG1 -0.84 -14.79 -0.63 2.09e-38 Cognitive function; LUSC cis rs34779708 0.966 rs2505639 chr10:35474421 A/G cg04310649 chr10:35416472 CREM 0.4 6.36 0.33 6.72e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg04287289 chr16:89883240 FANCA 0.78 13.34 0.59 7.98e-33 Vitiligo; LUSC cis rs6700896 0.931 rs12035753 chr1:66116691 T/G cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.43 0.42 1.08e-15 Prudent dietary pattern; LUSC cis rs1790761 0.667 rs591434 chr11:67337814 C/T cg08355456 chr11:67383691 NA 0.38 7.01 0.36 1.35e-11 Mean corpuscular volume; LUSC cis rs3806843 0.548 rs246057 chr5:140325583 A/G cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg01652190 chr22:50026171 C22orf34 -0.31 -6.39 -0.33 5.51e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg09640425 chr7:158790006 NA -0.42 -6.49 -0.33 3.09e-10 Facial morphology (factor 20); LUSC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg07741184 chr6:167504864 NA 0.43 7.59 0.38 3.18e-13 Crohn's disease; LUSC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg17848003 chr1:3704513 LRRC47 0.34 6.15 0.32 2.18e-9 Red cell distribution width; LUSC cis rs2219968 0.828 rs13248588 chr8:78880744 A/G cg00738934 chr8:78996279 NA -0.38 -6.71 -0.34 8.44e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.17e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs3092073 0.624 rs3848714 chr20:44547176 T/C cg17986701 chr20:44574422 PCIF1 0.37 6.57 0.34 1.94e-10 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg06873352 chr17:61820015 STRADA 0.71 12.78 0.57 9.99e-31 Prudent dietary pattern; LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg07507251 chr3:52567010 NT5DC2 -0.32 -6.29 -0.33 9.86e-10 Bipolar disorder; LUSC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg12463550 chr7:65579703 CRCP 0.55 8.22 0.41 4.5e-15 Aortic root size; LUSC cis rs72781680 1.000 rs72781671 chr2:24231123 A/G cg20701182 chr2:24300061 SF3B14 0.75 7.62 0.38 2.73e-13 Lymphocyte counts; LUSC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.09 -0.32 3.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg05738196 chr6:26577821 NA -0.51 -6.08 -0.32 3.27e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.64 0.5 5.88e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg12639453 chr1:2035780 PRKCZ -0.31 -6.54 -0.34 2.38e-10 Height; LUSC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg07395648 chr5:131743802 NA 0.38 5.92 0.31 7.78e-9 Asthma (sex interaction); LUSC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg03289416 chr15:75166202 SCAMP2 0.44 6.95 0.36 1.95e-11 Breast cancer; LUSC cis rs864537 0.618 rs1214595 chr1:167427557 G/A cg22356347 chr1:167427500 CD247 -0.35 -8.33 -0.41 2.07e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC trans rs9291683 0.527 rs3822241 chr4:10094931 G/A cg26043149 chr18:55253948 FECH -0.52 -7.72 -0.39 1.37e-13 Bone mineral density; LUSC cis rs72781680 1.000 rs12617839 chr2:24166277 A/T cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs11098499 0.532 rs12512646 chr4:120585733 G/A cg09307838 chr4:120376055 NA 0.69 9.72 0.47 7.6e-20 Corneal astigmatism; LUSC cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.84 -0.3 1.25e-8 Extrinsic epigenetic age acceleration; LUSC cis rs12618769 0.543 rs58778964 chr2:99110599 G/C cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs12681287 0.571 rs13254675 chr8:87353594 C/T cg27223183 chr8:87520930 FAM82B -0.54 -7.17 -0.37 4.86e-12 Caudate activity during reward; LUSC cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs4268898 0.662 rs2303297 chr2:24432937 C/T cg06627628 chr2:24431161 ITSN2 -0.89 -13.28 -0.59 1.29e-32 Asthma; LUSC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg01579765 chr21:45077557 HSF2BP -0.53 -11.38 -0.53 1.35e-25 Mean corpuscular volume; LUSC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg12463550 chr7:65579703 CRCP -0.42 -6.04 -0.31 4.22e-9 Calcium levels; LUSC cis rs877282 0.891 rs11253355 chr10:768367 C/G cg17470449 chr10:769945 NA 0.55 7.79 0.39 8.33e-14 Uric acid levels; LUSC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs9326248 0.581 rs10892076 chr11:116988936 G/A cg01368799 chr11:117014884 PAFAH1B2 0.61 9.46 0.46 5.87e-19 Blood protein levels; LUSC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.15 -0.32 2.19e-9 Alzheimer's disease (late onset); LUSC cis rs8078723 0.714 rs2241245 chr17:38151014 C/T cg17467752 chr17:38218738 THRA -0.7 -11.27 -0.52 3.54e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs1595825 0.891 rs114426561 chr2:198698891 A/G cg00982548 chr2:198649783 BOLL -0.58 -7.2 -0.37 3.9e-12 Ulcerative colitis; LUSC cis rs17401966 0.931 rs12753426 chr1:10372110 T/C cg19773385 chr1:10388646 KIF1B -0.5 -8.39 -0.42 1.38e-15 Hepatocellular carcinoma; LUSC cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC trans rs1005277 0.579 rs2505257 chr10:38372664 A/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.6 -0.47 2.03e-19 Extrinsic epigenetic age acceleration; LUSC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.88e-19 Developmental language disorder (linguistic errors); LUSC cis rs6960043 0.818 rs1974619 chr7:15065300 C/T cg19272540 chr7:15055459 NA -0.31 -7.64 -0.39 2.31e-13 Type 2 diabetes; LUSC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg21724239 chr8:58056113 NA -0.78 -8.35 -0.42 1.78e-15 Developmental language disorder (linguistic errors); LUSC cis rs1595825 0.945 rs7581202 chr2:198836777 A/G cg10547527 chr2:198650123 BOLL -0.5 -5.9 -0.31 9.07e-9 Ulcerative colitis; LUSC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg17366294 chr4:99064904 C4orf37 0.53 8.74 0.43 1.17e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg02951883 chr7:2050386 MAD1L1 -0.52 -9.26 -0.45 2.56e-18 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -10.01 -0.48 8.56e-21 Personality dimensions; LUSC cis rs11758351 0.866 rs75091077 chr6:26207546 A/C cg01420254 chr6:26195488 NA 0.63 7.08 0.36 8.45e-12 Gout;Renal underexcretion gout; LUSC cis rs8032315 1.000 rs2071410 chr15:91420940 C/G cg05469396 chr15:91419421 FURIN -0.42 -6.51 -0.34 2.72e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg00684032 chr4:1343700 KIAA1530 0.34 5.96 0.31 6.54e-9 Obesity-related traits; LUSC cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg13010199 chr12:38710504 ALG10B 0.66 10.09 0.48 4.48e-21 Bladder cancer; LUSC cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.41 -6.9 -0.35 2.68e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg04756594 chr16:24857601 SLC5A11 0.37 6.18 0.32 1.9e-9 Intelligence (multi-trait analysis); LUSC cis rs9905704 0.671 rs4337355 chr17:56950920 C/T cg12560992 chr17:57184187 TRIM37 0.59 9.47 0.46 5.35e-19 Testicular germ cell tumor; LUSC cis rs6424115 0.733 rs2502996 chr1:24199041 T/C cg15997130 chr1:24165203 NA 0.52 8.62 0.43 2.63e-16 Immature fraction of reticulocytes; LUSC cis rs9329221 0.638 rs7460436 chr8:10254322 C/T cg21775007 chr8:11205619 TDH 0.46 5.87 0.31 1.05e-8 Neuroticism; LUSC cis rs2797160 1.000 rs1935774 chr6:125996661 A/G cg05901451 chr6:126070800 HEY2 0.58 8.91 0.44 3.42e-17 Endometrial cancer; LUSC cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg05729581 chr11:3078854 CARS -0.53 -8.32 -0.41 2.19e-15 Longevity; LUSC cis rs9906944 0.707 rs9899931 chr17:47108282 G/A cg14634687 chr17:47094252 IGF2BP1 0.31 6.54 0.34 2.26e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC trans rs6445975 0.572 rs4320076 chr3:58405284 T/G cg18950693 chr14:70346909 SMOC1 -0.4 -6.03 -0.31 4.25e-9 Systemic lupus erythematosus; LUSC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.25 0.45 2.73e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs6964587 0.836 rs757040 chr7:91552016 A/G cg17063962 chr7:91808500 NA -0.51 -7.66 -0.39 1.97e-13 Breast cancer; LUSC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg17420585 chr12:42539391 GXYLT1 0.4 7.79 0.39 8.36e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9473147 0.516 rs9349415 chr6:47551861 T/C cg02130027 chr6:47444894 CD2AP 0.35 5.7 0.3 2.68e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7586879 0.789 rs13404163 chr2:25126616 A/G cg01884057 chr2:25150051 NA 0.42 8.8 0.43 7.49e-17 Body mass index; LUSC cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg18252515 chr7:66147081 NA -1.19 -12.83 -0.57 6.75e-31 Diabetic kidney disease; LUSC cis rs2404618 0.534 rs2214861 chr8:1490604 A/G cg02903104 chr8:1507517 DLGAP2 0.39 7.6 0.38 3.11e-13 Lung cancer; LUSC cis rs6942756 0.806 rs9641846 chr7:128873679 G/A cg02491457 chr7:128862824 NA 0.52 7.83 0.39 6.39e-14 White matter hyperintensity burden; LUSC cis rs9674544 0.757 rs4410130 chr17:47122942 C/T cg10950924 chr17:47092072 IGF2BP1 0.38 5.93 0.31 7.73e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); LUSC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg08859206 chr1:53392774 SCP2 -0.41 -6.62 -0.34 1.41e-10 Monocyte count; LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg07703079 chr11:430292 ANO9 0.57 6.27 0.32 1.14e-9 Body mass index; LUSC cis rs9650315 0.929 rs35423308 chr8:57201836 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.31 0.37 1.93e-12 Height; LUSC cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg24642439 chr20:33292090 TP53INP2 0.42 6.07 0.32 3.38e-9 Height; LUSC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg21880101 chr17:80066754 CCDC57 0.31 5.85 0.3 1.17e-8 Life satisfaction; LUSC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg21972741 chr5:435613 AHRR 0.37 6.99 0.36 1.47e-11 Cystic fibrosis severity; LUSC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg02428538 chr16:24856791 SLC5A11 0.6 6.85 0.35 3.59e-11 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs12310956 0.510 rs10772109 chr12:33839548 A/C cg26384229 chr12:38710491 ALG10B -0.54 -8.24 -0.41 4.01e-15 Morning vs. evening chronotype; LUSC cis rs1865760 0.865 rs1436306 chr6:25948421 A/G cg12310025 chr6:25882481 NA -0.34 -5.69 -0.3 2.74e-8 Height; LUSC cis rs2721195 0.967 rs11777703 chr8:145703508 G/A cg11211951 chr8:145729740 GPT -0.58 -11.15 -0.52 9.59e-25 Age at first birth; LUSC trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs11585357 0.842 rs72633804 chr1:17617024 T/C cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC trans rs2786098 0.656 rs12028758 chr1:197522958 C/T cg16005942 chr6:160526640 IGF2R 0.52 6.59 0.34 1.7e-10 Asthma; LUSC cis rs9395066 0.527 rs12524069 chr6:44897973 C/A cg25276700 chr6:44698697 NA 0.31 6.21 0.32 1.57e-9 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg22745437 chr19:38397769 WDR87;SIPA1L3 0.75 5.95 0.31 6.94e-9 Cognitive performance; LUSC cis rs2273669 0.667 rs76201299 chr6:109344975 T/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 9.1e-9 Prostate cancer; LUSC cis rs4343996 1.000 rs6461994 chr7:3356483 C/G cg21248987 chr7:3385318 SDK1 -0.35 -5.94 -0.31 7.05e-9 Motion sickness; LUSC cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.16 0.41 6.97e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs600231 0.665 rs1626021 chr11:65226187 A/G cg17120908 chr11:65337727 SSSCA1 -0.55 -9.61 -0.47 1.78e-19 Bone mineral density; LUSC cis rs11785400 0.793 rs4736364 chr8:143742113 C/T cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs6121246 0.567 rs6060263 chr20:30193110 T/C cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.67 -11.62 -0.54 1.99e-26 Personality dimensions; LUSC trans rs9329221 0.537 rs1484640 chr8:9983243 G/T cg08975724 chr8:8085496 FLJ10661 0.42 6.0 0.31 5.18e-9 Neuroticism; LUSC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg27165867 chr14:105738592 BRF1 -0.51 -7.42 -0.38 9.52e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs921968 0.565 rs35358516 chr2:219625723 A/C cg02176678 chr2:219576539 TTLL4 -0.58 -10.36 -0.49 5.62e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs78572108 0.858 rs10183814 chr2:42262064 T/C cg00607755 chr2:42274082 PKDCC 0.35 6.24 0.32 1.34e-9 Total body bone mineral density; LUSC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg01570182 chr17:44337453 NA 0.7 10.6 0.5 8.01e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs290268 1.000 rs290271 chr9:93551619 G/A cg02608019 chr9:93564028 SYK 0.55 9.13 0.45 6.57e-18 Platelet count; LUSC cis rs9549260 0.755 rs2297627 chr13:41233931 A/G cg21288729 chr13:41239152 FOXO1 0.6 9.24 0.45 3.02e-18 Red blood cell count; LUSC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg11764359 chr7:65958608 NA 0.7 10.86 0.51 9.8e-24 Aortic root size; LUSC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg12639453 chr1:2035780 PRKCZ 0.28 5.88 0.31 1.01e-8 Height; LUSC trans rs72674100 1.000 rs28630925 chr4:97991385 G/T cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.658 rs426147 chr1:153045011 G/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.39 -0.37 1.19e-12 Inflammatory skin disease; LUSC cis rs1775715 0.870 rs11008700 chr10:32236937 A/G cg26784012 chr10:32216390 ARHGAP12 0.36 5.83 0.3 1.3e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg24838063 chr12:130822603 PIWIL1 0.67 10.27 0.49 1.1e-21 Menopause (age at onset); LUSC cis rs6696846 0.765 rs61822568 chr1:205081166 C/G cg21545522 chr1:205238299 TMCC2 0.46 8.6 0.43 3.05e-16 Red blood cell count; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg26828218 chr2:219264796 CTDSP1 0.53 7.05 0.36 1e-11 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg02175503 chr12:58329896 NA 0.55 8.79 0.43 7.88e-17 Intelligence (multi-trait analysis); LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg11645453 chr3:52864694 ITIH4 0.35 8.13 0.41 8.33e-15 Bipolar disorder; LUSC cis rs778371 0.723 rs1022329 chr2:233591239 T/C cg08000102 chr2:233561755 GIGYF2 0.81 14.03 0.61 1.85e-35 Schizophrenia; LUSC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg19592336 chr6:28129416 ZNF389 0.48 6.3 0.33 9.46e-10 Depression; LUSC cis rs3740713 1.000 rs16935432 chr11:18470487 G/A cg07915343 chr11:18477680 LDHAL6A -0.54 -6.74 -0.35 6.85e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs644148 0.500 rs2686773 chr19:44999802 G/A cg15540054 chr19:45004280 ZNF180 -0.44 -6.05 -0.31 3.91e-9 Personality dimensions; LUSC cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs4595586 0.545 rs925827 chr12:39364307 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.45 0.38 7.82e-13 Morning vs. evening chronotype; LUSC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg20135002 chr11:47629003 NA -0.52 -8.12 -0.41 8.82e-15 Subjective well-being; LUSC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11644478 chr21:40555479 PSMG1 -0.75 -13.36 -0.59 6.48e-33 Cognitive function; LUSC trans rs7944735 0.671 rs7106731 chr11:48003392 T/G cg15704280 chr7:45808275 SEPT13 0.55 6.6 0.34 1.64e-10 Intraocular pressure; LUSC cis rs1595825 0.945 rs73058818 chr2:198862600 C/T cg00982548 chr2:198649783 BOLL -0.56 -7.15 -0.36 5.59e-12 Ulcerative colitis; LUSC cis rs9388451 0.903 rs7758115 chr6:126061502 C/T cg10911889 chr6:126070802 HEY2 0.4 6.14 0.32 2.28e-9 Brugada syndrome; LUSC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg09491104 chr22:46646882 C22orf40 -0.63 -7.26 -0.37 2.76e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs11190604 1.000 rs3763695 chr10:102269206 A/G cg16342193 chr10:102329863 NA -0.35 -6.42 -0.33 4.6e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg13010199 chr12:38710504 ALG10B 0.66 9.93 0.48 1.57e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs7659604 0.540 rs9995322 chr4:122675642 G/A cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg06784218 chr1:46089804 CCDC17 0.49 9.73 0.47 7.31e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs6600671 1.000 rs7532615 chr1:121172840 G/T cg00646200 chr1:148855367 NA -0.4 -6.39 -0.33 5.5e-10 Hip geometry; LUSC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg03517284 chr6:25882590 NA -0.39 -6.95 -0.36 1.89e-11 Height; LUSC cis rs11155671 0.530 rs9371542 chr6:150213085 A/T cg04369109 chr6:150039330 LATS1 -0.41 -5.79 -0.3 1.64e-8 Testicular germ cell tumor; LUSC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg20135002 chr11:47629003 NA 0.48 7.57 0.38 3.71e-13 Subjective well-being; LUSC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg12311346 chr5:56204834 C5orf35 -0.66 -10.07 -0.48 5.26e-21 Coronary artery disease; LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -12.07 -0.55 4.48e-28 Platelet count; LUSC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg08470875 chr2:26401718 FAM59B -0.71 -9.6 -0.47 1.92e-19 Gut microbiome composition (summer); LUSC cis rs2629540 0.889 rs4962402 chr10:126459114 T/G cg08799069 chr10:126477246 METTL10 -0.68 -10.11 -0.48 3.87e-21 Cocaine dependence; LUSC cis rs8114671 0.562 rs2378292 chr20:33485178 T/C cg08999081 chr20:33150536 PIGU 0.33 5.7 0.3 2.59e-8 Height; LUSC cis rs2991971 1.000 rs2991972 chr1:46013208 C/T cg24296786 chr1:45957014 TESK2 0.48 7.01 0.36 1.29e-11 High light scatter reticulocyte count; LUSC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg11871910 chr12:69753446 YEATS4 0.83 14.58 0.62 1.34e-37 Blood protein levels; LUSC trans rs2797160 1.000 rs6934435 chr6:126017481 T/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.87 0.35 3.16e-11 Endometrial cancer; LUSC trans rs7615952 0.641 rs12487875 chr3:125787224 C/A cg07211511 chr3:129823064 LOC729375 -0.75 -9.78 -0.47 4.94e-20 Blood pressure (smoking interaction); LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg00814883 chr7:100076585 TSC22D4 -0.67 -8.72 -0.43 1.34e-16 Platelet count; LUSC cis rs7954584 0.626 rs10840637 chr12:122427310 A/G cg10207240 chr12:122356781 WDR66 0.43 6.15 0.32 2.22e-9 Mean corpuscular volume; LUSC cis rs9467773 1.000 rs9461259 chr6:26504835 C/A cg05738196 chr6:26577821 NA 0.81 15.2 0.64 4.95e-40 Intelligence (multi-trait analysis); LUSC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg12288994 chr5:1860383 NA 0.31 6.98 0.36 1.6e-11 Cardiovascular disease risk factors; LUSC cis rs13315871 1.000 rs11708590 chr3:58336635 A/G cg20936604 chr3:58311152 NA 0.66 6.71 0.34 8.57e-11 Cholesterol, total; LUSC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg12257692 chr3:49977190 RBM6 -0.26 -7.13 -0.36 6.45e-12 Intelligence (multi-trait analysis); LUSC cis rs2286885 0.965 rs4836548 chr9:129255456 G/A cg15282417 chr9:129245246 FAM125B 0.41 6.82 0.35 4.27e-11 Intraocular pressure; LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg04518342 chr5:131593106 PDLIM4 0.44 7.66 0.39 2.04e-13 Breast cancer; LUSC trans rs236907 0.814 rs6695933 chr1:171774239 A/C cg13482142 chr2:234261155 NA 0.52 6.19 0.32 1.79e-9 Mean platelet volume; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg13395646 chr4:1353034 KIAA1530 -0.62 -10.12 -0.48 3.66e-21 Obesity-related traits; LUSC trans rs877282 0.700 rs816311 chr10:796490 C/A cg13042288 chr15:90349979 ANPEP -0.42 -6.51 -0.34 2.71e-10 Uric acid levels; LUSC cis rs939658 0.683 rs8041222 chr15:79465549 A/G cg17916960 chr15:79447300 NA -0.39 -7.18 -0.37 4.52e-12 Refractive error; LUSC cis rs4700695 0.719 rs27584 chr5:65445232 G/A cg21114390 chr5:65439923 SFRS12 -0.64 -9.15 -0.45 5.85e-18 Facial morphology (factor 19); LUSC cis rs1371867 1.000 rs1371867 chr8:101330209 A/C cg00191853 chr8:101177733 SPAG1 -0.36 -6.04 -0.31 4.05e-9 Atrioventricular conduction; LUSC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Parkinson's disease; LUSC cis rs1385374 0.858 rs10847697 chr12:129299385 C/T cg09035930 chr12:129282057 SLC15A4 -0.58 -6.47 -0.33 3.41e-10 Systemic lupus erythematosus; LUSC cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg23029597 chr12:123009494 RSRC2 -0.6 -8.51 -0.42 5.81e-16 Body mass index; LUSC cis rs151234 0.676 rs554206 chr16:28576369 G/A cg01378222 chr16:28622494 SULT1A1 -0.62 -8.34 -0.42 1.91e-15 Platelet distribution width; LUSC trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg25482853 chr8:67687455 SGK3 1.2 16.99 0.68 4.47e-47 Lung disease severity in cystic fibrosis; LUSC cis rs2204008 0.777 rs6582664 chr12:37947022 A/G cg26384229 chr12:38710491 ALG10B -0.8 -13.3 -0.59 1.08e-32 Bladder cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04130928 chr5:176449623 ZNF346 -0.4 -6.0 -0.31 5.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11971779 0.680 rs66491565 chr7:139088977 C/G cg07862535 chr7:139043722 LUC7L2 0.59 7.37 0.37 1.32e-12 Diisocyanate-induced asthma; LUSC cis rs3772130 0.962 rs9826473 chr3:121556219 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.72 10.43 0.5 3.12e-22 Cognitive performance; LUSC cis rs1348850 0.574 rs2365617 chr2:178421934 C/A cg22681709 chr2:178499509 PDE11A -0.42 -5.87 -0.31 1.04e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg08999081 chr20:33150536 PIGU 0.52 10.27 0.49 1.14e-21 Glomerular filtration rate (creatinine); LUSC cis rs3087591 0.801 rs2012535 chr17:29561391 A/T cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.86 -0.4 5.37e-14 Hip circumference; LUSC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs11088226 0.709 rs55860967 chr21:33880018 G/A cg09050820 chr6:167586206 TCP10L2 0.48 6.03 0.31 4.38e-9 Gastritis; LUSC cis rs17270561 0.609 rs4145217 chr6:25743997 T/C cg16482183 chr6:26056742 HIST1H1C 0.63 9.07 0.44 1.01e-17 Iron status biomarkers; LUSC cis rs2777491 0.915 rs8032838 chr15:41605632 G/A cg18705301 chr15:41695430 NDUFAF1 -0.73 -13.36 -0.59 6.47e-33 Ulcerative colitis; LUSC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg18240062 chr17:79603768 NPLOC4 0.71 12.97 0.58 1.96e-31 Eye color traits; LUSC cis rs778371 1.000 rs709937 chr2:233744021 A/G cg08000102 chr2:233561755 GIGYF2 0.73 10.96 0.51 4.46e-24 Schizophrenia; LUSC trans rs1997103 1.000 rs9649781 chr7:55411809 A/G cg20935933 chr6:143382018 AIG1 0.51 7.39 0.37 1.21e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs2018683 0.899 rs10479817 chr7:28978148 A/C cg19402173 chr7:128379420 CALU -0.53 -8.41 -0.42 1.21e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC cis rs7177699 0.557 rs7403714 chr15:79118650 C/T cg00540400 chr15:79124168 NA -0.47 -7.96 -0.4 2.75e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg03065625 chr11:46941490 LRP4 0.39 6.16 0.32 2.12e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg10802521 chr3:52805072 NEK4 -0.56 -9.05 -0.44 1.24e-17 Bipolar disorder; LUSC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg02569458 chr12:86230093 RASSF9 0.49 8.2 0.41 5.16e-15 Major depressive disorder; LUSC cis rs10754283 0.967 rs12058749 chr1:90105604 C/T cg21401794 chr1:90099060 LRRC8C 0.67 10.02 0.48 7.75e-21 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg04865166 chr7:105162814 PUS7 -0.52 -5.79 -0.3 1.6e-8 Bipolar disorder (body mass index interaction); LUSC cis rs17401966 1.000 rs12141416 chr1:10327867 A/G cg19773385 chr1:10388646 KIF1B -0.57 -9.87 -0.48 2.58e-20 Hepatocellular carcinoma; LUSC cis rs2404602 0.967 rs7167613 chr15:77041192 C/A cg22467129 chr15:76604101 ETFA -0.42 -6.59 -0.34 1.72e-10 Blood metabolite levels; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.86 0.35 3.37e-11 Obesity-related traits; LUSC trans rs11148252 0.514 rs3818422 chr13:52719214 C/T cg18335740 chr13:41363409 SLC25A15 -0.46 -6.88 -0.35 2.95e-11 Lewy body disease; LUSC cis rs6942756 1.000 rs4440569 chr7:128923907 T/A cg02491457 chr7:128862824 NA -0.49 -6.72 -0.35 7.96e-11 White matter hyperintensity burden; LUSC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg26818010 chr10:134567672 INPP5A -0.84 -10.95 -0.51 4.73e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6704644 0.584 rs56336977 chr2:234357496 C/T cg05711037 chr2:234359783 DGKD 0.62 6.54 0.34 2.27e-10 Bilirubin levels; LUSC cis rs7582180 0.764 rs7425449 chr2:100928393 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.69 -0.43 1.65e-16 Intelligence (multi-trait analysis); LUSC cis rs11048434 0.761 rs12828902 chr12:9132231 C/T cg23795048 chr12:9217529 LOC144571 0.33 5.8 0.3 1.55e-8 Sjögren's syndrome; LUSC cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg12935359 chr14:103987150 CKB 0.6 9.08 0.44 9.73e-18 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13387677 chr22:38203802 GCAT -0.39 -5.98 -0.31 5.61e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6498114 0.652 rs3087456 chr16:10970902 G/A cg03103192 chr4:52917271 SPATA18 0.33 6.3 0.33 9.14e-10 Nasopharyngeal carcinoma; LUSC cis rs4820294 0.669 rs9622678 chr22:38057338 A/G cg21798802 chr22:38057573 PDXP 0.35 7.43 0.38 9.29e-13 Fat distribution (HIV); LUSC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg08704250 chr15:31115839 NA -0.59 -9.24 -0.45 2.97e-18 Huntington's disease progression; LUSC cis rs10875746 0.951 rs61918826 chr12:48543978 T/C cg13454099 chr12:49076203 C12orf41 -0.52 -6.15 -0.32 2.17e-9 Longevity (90 years and older); LUSC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.59 -0.34 1.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9811920 0.809 rs766778 chr3:99751480 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.56 -0.34 2.07e-10 Axial length; LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg27170947 chr2:26402098 FAM59B -0.69 -10.55 -0.5 1.2e-22 Gut microbiome composition (summer); LUSC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg16520312 chr17:43971471 MAPT;LOC100128977 0.36 6.19 0.32 1.78e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8014204 0.836 rs7154256 chr14:75252587 A/G cg06637938 chr14:75390232 RPS6KL1 0.62 10.27 0.49 1.06e-21 Caffeine consumption; LUSC cis rs1419980 0.673 rs12366473 chr12:7728270 G/C cg25828445 chr12:7781288 NA 0.62 6.45 0.33 3.88e-10 HDL cholesterol levels; LUSC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.3 -0.41 2.62e-15 Mean platelet volume; LUSC cis rs9329221 0.662 rs11249996 chr8:10245463 G/T cg21775007 chr8:11205619 TDH -0.44 -5.84 -0.3 1.27e-8 Neuroticism; LUSC cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.69 -0.34 9.42e-11 Monocyte percentage of white cells; LUSC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg13175981 chr1:150552382 MCL1 0.47 6.62 0.34 1.44e-10 Tonsillectomy; LUSC trans rs11098499 0.954 rs878373 chr4:120237484 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.22 0.32 1.49e-9 Corneal astigmatism; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg06784218 chr1:46089804 CCDC17 0.56 11.62 0.54 1.92e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02018176 chr4:1364513 KIAA1530 0.72 13.44 0.59 3.19e-33 Longevity; LUSC cis rs7584330 0.784 rs6724766 chr2:238413600 A/G cg16989719 chr2:238392110 NA -0.39 -6.62 -0.34 1.41e-10 Prostate cancer; LUSC cis rs9359856 0.564 rs72917989 chr6:90470385 A/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.2 -0.41 5.08e-15 Bipolar disorder; LUSC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg23283495 chr1:209979779 IRF6 -0.68 -8.17 -0.41 6.3e-15 Cleft lip with or without cleft palate; LUSC cis rs9399135 0.844 rs13209789 chr6:135367916 A/G cg22676075 chr6:135203613 NA 0.46 7.13 0.36 6.1e-12 Red blood cell count; LUSC cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.67 -0.3 3.01e-8 Extrinsic epigenetic age acceleration; LUSC cis rs9788721 0.802 rs56219465 chr15:78742579 A/G cg18825076 chr15:78729989 IREB2 -0.59 -9.73 -0.47 7.2e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs1728785 0.901 rs11075687 chr16:68655894 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.86 0.4 5.2e-14 Ulcerative colitis; LUSC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg00074818 chr8:8560427 CLDN23 0.57 9.75 0.47 6.48e-20 Obesity-related traits; LUSC cis rs6815814 0.904 rs7664239 chr4:38786304 T/C cg06935464 chr4:38784597 TLR10 0.46 5.94 0.31 7.29e-9 Breast cancer; LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13126279 chr21:47581558 C21orf56 -0.54 -8.37 -0.42 1.63e-15 Testicular germ cell tumor; LUSC cis rs9811920 0.809 rs7649349 chr3:99725629 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 5.9 0.31 9e-9 Axial length; LUSC cis rs1568889 1.000 rs11602768 chr11:28351786 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 8.87 0.44 4.52e-17 Bipolar disorder; LUSC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg01191920 chr7:158217561 PTPRN2 -0.59 -12.15 -0.55 2.3e-28 Obesity-related traits; LUSC cis rs950027 1.000 rs950027 chr15:45801035 C/T cg26924012 chr15:45694286 SPATA5L1 -0.55 -8.18 -0.41 6.07e-15 Response to fenofibrate (adiponectin levels); LUSC cis rs929354 0.772 rs1182442 chr7:157026633 G/A cg05182265 chr7:156933206 UBE3C 0.59 9.5 0.46 4.17e-19 Body mass index; LUSC cis rs2235649 0.623 rs8048162 chr16:1848918 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -5.92 -0.31 7.81e-9 Blood metabolite levels; LUSC cis rs2204008 0.807 rs10880234 chr12:38318353 C/T cg26384229 chr12:38710491 ALG10B 0.85 13.54 0.6 1.3e-33 Bladder cancer; LUSC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg22433210 chr17:43662623 NA -0.73 -10.65 -0.5 5.56e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg15839431 chr19:19639596 YJEFN3 -0.41 -5.73 -0.3 2.25e-8 Tonsillectomy; LUSC cis rs12594515 1.000 rs8026221 chr15:45987910 G/T cg01629716 chr15:45996671 NA 0.4 6.06 0.31 3.68e-9 Waist circumference;Weight; LUSC cis rs367943 1.000 rs348925 chr5:112817533 T/A cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs2976388 1.000 rs2978982 chr8:143763490 T/C cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg00864171 chr11:67383662 NA 0.34 6.02 0.31 4.72e-9 Mean corpuscular volume; LUSC cis rs4631830 0.733 rs4512771 chr10:51540906 C/A cg16070123 chr10:51489643 NA -0.48 -7.4 -0.38 1.08e-12 Prostate-specific antigen levels; LUSC cis rs7607369 0.759 rs10179708 chr2:219390967 T/A cg02176678 chr2:219576539 TTLL4 -0.74 -14.3 -0.62 1.65e-36 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs6163 0.588 rs3818708 chr10:104503584 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.47 -7.01 -0.36 1.34e-11 Waist circumference;Hip circumference; LUSC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC cis rs1018836 0.637 rs6471113 chr8:91519735 A/G cg16814680 chr8:91681699 NA -0.64 -9.57 -0.46 2.4e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs28830936 0.966 rs2277535 chr15:42119711 G/A cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.92 -0.31 7.95e-9 Diastolic blood pressure; LUSC trans rs7939886 0.920 rs60087290 chr11:55983527 C/G cg03929089 chr4:120376271 NA 0.82 6.13 0.32 2.55e-9 Myopia (pathological); LUSC cis rs17685 0.753 rs1637037 chr7:75692927 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.68 -0.39 1.74e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg05738196 chr6:26577821 NA 0.5 7.16 0.36 5.23e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg09365446 chr1:150670422 GOLPH3L -0.5 -7.32 -0.37 1.86e-12 Urate levels; LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg18876405 chr7:65276391 NA 0.51 7.85 0.39 5.58e-14 Calcium levels; LUSC trans rs9929218 1.000 rs9929218 chr16:68820946 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -11.06 -0.52 1.97e-24 Colorectal cancer; LUSC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg15445000 chr17:37608096 MED1 0.4 6.74 0.35 6.92e-11 Glomerular filtration rate (creatinine); LUSC cis rs34375054 0.738 rs3751181 chr12:125626535 A/G cg06287003 chr12:125626642 AACS -0.4 -7.18 -0.37 4.64e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg14993813 chr1:46806288 NSUN4 -0.53 -7.39 -0.37 1.18e-12 Menopause (age at onset); LUSC cis rs9467773 0.620 rs2494694 chr6:26619328 A/T cg09904177 chr6:26538194 HMGN4 0.65 11.67 0.54 1.3e-26 Intelligence (multi-trait analysis); LUSC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.42e-14 Eye color traits; LUSC cis rs10950821 0.530 rs6950224 chr7:20688109 G/C cg02470904 chr7:20686108 ABCB5 0.33 5.89 0.31 9.35e-9 Response to statin therapy; LUSC cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg27284194 chr4:1044797 NA 0.4 6.32 0.33 8.3e-10 Longevity; LUSC cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC cis rs7520050 0.778 rs3014216 chr1:46035760 A/T cg06784218 chr1:46089804 CCDC17 0.31 5.98 0.31 5.76e-9 Red blood cell count;Reticulocyte count; LUSC trans rs35110281 0.627 rs1836855 chr21:44965414 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.21 0.49 1.73e-21 Mean corpuscular volume; LUSC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg01475377 chr6:109611718 NA -0.36 -6.4 -0.33 5.29e-10 Reticulocyte fraction of red cells; LUSC cis rs2361710 0.668 rs2304855 chr17:78118266 T/A cg20811857 chr17:78079795 GAA -0.32 -6.06 -0.31 3.59e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg04155289 chr7:94953770 PON1 -0.36 -6.16 -0.32 2.07e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6690583 0.623 rs2083284 chr1:85440023 C/T cg11262906 chr1:85462892 MCOLN2 0.68 6.46 0.33 3.67e-10 Serum sulfate level; LUSC cis rs6591182 0.503 rs11227241 chr11:65389890 G/C cg27068330 chr11:65405492 SIPA1 -0.68 -9.55 -0.46 2.82e-19 Non-alcoholic fatty liver disease histology (lobular); LUSC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg00791764 chr4:53727839 RASL11B 0.58 7.98 0.4 2.42e-14 Optic nerve measurement (cup area); LUSC cis rs7582180 0.629 rs4850927 chr2:100969067 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.58 -0.43 3.56e-16 Intelligence (multi-trait analysis); LUSC cis rs3849570 0.615 rs35779564 chr3:81982771 G/A cg07356753 chr3:81810745 GBE1 -0.52 -7.45 -0.38 8.07e-13 Waist circumference;Body mass index; LUSC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg03289416 chr15:75166202 SCAMP2 0.45 6.88 0.35 2.9100000000000002e-11 Breast cancer; LUSC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg06671706 chr8:8559999 CLDN23 -0.47 -6.2 -0.32 1.65e-9 Obesity-related traits; LUSC trans rs72674100 1.000 rs28575922 chr4:97974891 C/A cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs61931739 0.635 rs1405024 chr12:33937939 A/T cg26384229 chr12:38710491 ALG10B -0.5 -7.63 -0.39 2.52e-13 Morning vs. evening chronotype; LUSC cis rs4343996 0.542 rs6969267 chr7:3435750 T/C cg21248987 chr7:3385318 SDK1 0.35 5.67 0.3 3.09e-8 Motion sickness; LUSC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg17971929 chr21:40555470 PSMG1 0.8 14.01 0.61 2.13e-35 Cognitive function; LUSC cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg06784218 chr1:46089804 CCDC17 0.56 11.2 0.52 6.35e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs4596713 0.568 rs7034303 chr9:71746871 A/G cg25283916 chr1:242222868 NA 0.3 6.15 0.32 2.25e-9 Headache; LUSC cis rs4654899 0.580 rs1977296 chr1:21091543 G/T cg01072550 chr1:21505969 NA -0.47 -7.05 -0.36 1.03e-11 Superior frontal gyrus grey matter volume; LUSC cis rs10752881 1.000 rs10911190 chr1:182979080 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.39e-23 Colorectal cancer; LUSC cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.78 -0.51 1.9e-23 Chronic sinus infection; LUSC cis rs9814567 1.000 rs6439487 chr3:134260860 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11155671 0.530 rs7764376 chr6:150210344 A/G cg07701084 chr6:150067640 NUP43 0.46 6.93 0.35 2.23e-11 Testicular germ cell tumor; LUSC cis rs10203711 1.000 rs7590907 chr2:239550312 T/C cg14580085 chr2:239553406 NA 0.37 6.08 0.32 3.32e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg22963979 chr7:1858916 MAD1L1 0.57 8.76 0.43 9.95e-17 Bipolar disorder and schizophrenia; LUSC cis rs12200560 0.505 rs211182 chr6:97074513 G/A cg06623918 chr6:96969491 KIAA0776 0.5 7.2 0.37 3.9e-12 Coronary heart disease; LUSC trans rs2235573 0.527 rs139865 chr22:38353932 C/G cg19894588 chr14:64061835 NA 0.51 7.34 0.37 1.6e-12 Glioblastoma;Glioma; LUSC cis rs12421382 0.659 rs1371332 chr11:109381687 A/T cg27471124 chr11:109292789 C11orf87 0.43 7.48 0.38 6.65e-13 Schizophrenia; LUSC cis rs941408 0.515 rs878893 chr19:2781325 A/G cg02580895 chr19:2754563 NA -0.48 -7.18 -0.37 4.57e-12 Total cholesterol levels; LUSC cis rs3020736 0.519 rs5996116 chr22:42517492 G/A cg04733989 chr22:42467013 NAGA -0.61 -9.41 -0.46 8.3e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs3020736 0.500 rs6002605 chr22:42494335 A/G cg05082376 chr22:42548792 NA 0.43 6.59 0.34 1.73e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9457247 0.765 rs6900701 chr6:167434112 A/G cg06454157 chr6:167490870 NA -0.25 -6.25 -0.32 1.28e-9 Crohn's disease; LUSC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg26314531 chr2:26401878 FAM59B -0.69 -9.44 -0.46 6.76e-19 Gut microbiome composition (summer); LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.42 -7.18 -0.37 4.42e-12 Prudent dietary pattern; LUSC cis rs10992471 0.756 rs7848055 chr9:95115492 A/C cg14631576 chr9:95140430 CENPP -0.35 -6.2 -0.32 1.62e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9346649 0.583 rs4708642 chr6:168491500 G/A cg02770688 chr6:168491649 NA 0.48 9.01 0.44 1.59e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg16132339 chr22:24313637 DDTL;DDT -0.41 -6.55 -0.34 2.17e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7647973 0.593 rs59684465 chr3:49874246 C/T cg13072238 chr3:49761600 GMPPB 0.68 8.78 0.43 8.64e-17 Menarche (age at onset); LUSC cis rs2658782 0.547 rs3020052 chr11:93055184 C/G cg15737290 chr11:93063684 CCDC67 0.88 13.93 0.61 4.47e-35 Pulmonary function decline; LUSC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg13390004 chr1:15929781 NA 0.42 7.1 0.36 7.7e-12 Systolic blood pressure; LUSC cis rs4654899 0.758 rs6702331 chr1:21516107 A/T cg01072550 chr1:21505969 NA -0.54 -8.26 -0.41 3.44e-15 Superior frontal gyrus grey matter volume; LUSC cis rs1865760 0.827 rs9295681 chr6:25944117 T/G cg17691542 chr6:26056736 HIST1H1C 0.48 7.16 0.36 5.26e-12 Height; LUSC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg14196790 chr5:131705035 SLC22A5 0.49 8.43 0.42 1.08e-15 Blood metabolite levels; LUSC cis rs2806561 0.704 rs1757039 chr1:23508657 A/G cg19743168 chr1:23544995 NA 0.41 7.96 0.4 2.75e-14 Height; LUSC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.0 0.44 1.76e-17 Total body bone mineral density; LUSC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7241530 0.662 rs72987826 chr18:75910795 T/C cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg02400238 chr19:44507710 ZNF230 0.52 6.17 0.32 1.94e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12493885 0.818 rs10935972 chr3:153774029 G/A cg17054900 chr3:154042577 DHX36 -0.74 -7.55 -0.38 4.06e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg13560548 chr3:10150139 C3orf24 0.5 7.04 0.36 1.07e-11 Alzheimer's disease; LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg24829409 chr8:58192753 C8orf71 -0.53 -6.17 -0.32 2.03e-9 Developmental language disorder (linguistic errors); LUSC trans rs7824557 0.701 rs4568582 chr8:11160495 A/T cg08975724 chr8:8085496 FLJ10661 0.44 6.4 0.33 5.2e-10 Retinal vascular caliber; LUSC cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.91 -0.35 2.51e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs939658 0.805 rs8035606 chr15:79420245 C/T cg17916960 chr15:79447300 NA -0.52 -10.31 -0.49 7.72e-22 Refractive error; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7715806 0.500 rs17563610 chr5:74981322 A/T cg19683494 chr5:74908142 NA 0.58 7.96 0.4 2.65e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7918232 0.567 rs11015463 chr10:27319258 A/G cg14442939 chr10:27389572 ANKRD26 0.51 6.12 0.32 2.61e-9 Breast cancer; LUSC cis rs1355223 1.000 rs12792532 chr11:34765782 G/T cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.84 -0.3 1.22e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg06740227 chr12:86229804 RASSF9 0.39 6.15 0.32 2.22e-9 Major depressive disorder; LUSC cis rs427941 0.632 rs201502 chr7:101759561 C/T cg06246474 chr7:101738831 CUX1 -0.36 -5.92 -0.31 7.97e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg19592336 chr6:28129416 ZNF389 0.48 6.29 0.33 1.02e-9 Depression; LUSC cis rs377070 1.000 rs377070 chr4:123629002 G/C cg10495464 chr4:123653540 BBS12;LOC729338 0.51 7.29 0.37 2.33e-12 Mosquito bite size; LUSC cis rs9815354 0.680 rs73073288 chr3:42027637 G/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg23649088 chr2:200775458 C2orf69 -0.57 -7.01 -0.36 1.33e-11 Schizophrenia; LUSC trans rs11098499 0.909 rs17046118 chr4:120387496 T/G cg25214090 chr10:38739885 LOC399744 0.58 8.45 0.42 9.1e-16 Corneal astigmatism; LUSC cis rs12478296 1.000 rs56323081 chr2:243040807 A/G cg06360820 chr2:242988706 NA -0.88 -9.7 -0.47 9.02e-20 Obesity-related traits; LUSC cis rs5769765 0.773 rs138834 chr22:50180497 A/C cg26441486 chr22:50317300 CRELD2 0.43 6.33 0.33 7.83e-10 Schizophrenia; LUSC cis rs208520 0.754 rs12204635 chr6:66740779 C/A cg07460842 chr6:66804631 NA 1.1 17.23 0.69 4.59e-48 Exhaled nitric oxide output; LUSC cis rs12545109 0.723 rs2610045 chr8:57413439 A/G cg09654669 chr8:57350985 NA 0.49 6.75 0.35 6.5500000000000006e-11 Obesity-related traits; LUSC cis rs12545109 0.765 rs2438063 chr8:57384360 A/G cg09654669 chr8:57350985 NA 0.58 7.95 0.4 2.92e-14 Obesity-related traits; LUSC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs2290416 0.681 rs3793371 chr8:144664299 C/T cg26536354 chr8:144654954 C8orf73 0.65 7.43 0.38 8.88e-13 Attention deficit hyperactivity disorder; LUSC cis rs2204008 0.668 rs1619009 chr12:38120485 G/A cg26384229 chr12:38710491 ALG10B -0.68 -10.45 -0.5 2.62e-22 Bladder cancer; LUSC cis rs78572108 0.858 rs4952579 chr2:42264741 C/G cg00607755 chr2:42274082 PKDCC 0.37 6.56 0.34 2.03e-10 Total body bone mineral density; LUSC cis rs950169 0.840 rs4842854 chr15:84942339 T/G cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs4319547 0.688 rs10847415 chr12:123144293 T/C cg23029597 chr12:123009494 RSRC2 -0.6 -8.09 -0.4 1.12e-14 Body mass index; LUSC cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg15839431 chr19:19639596 YJEFN3 -0.54 -5.85 -0.31 1.14e-8 Bipolar disorder; LUSC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs8060686 0.545 rs78229587 chr16:68165243 T/C cg05110241 chr16:68378359 PRMT7 -0.62 -6.65 -0.34 1.22e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg24642439 chr20:33292090 TP53INP2 0.6 9.46 0.46 5.6e-19 Coronary artery disease; LUSC cis rs9905704 0.918 rs430973 chr17:56709206 T/G cg12560992 chr17:57184187 TRIM37 0.56 7.98 0.4 2.41e-14 Testicular germ cell tumor; LUSC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -6.8 -0.35 4.8e-11 Alzheimer's disease (late onset); LUSC cis rs2115536 0.730 rs4573897 chr15:80187225 G/A cg02196730 chr15:80188777 MTHFS 0.41 6.18 0.32 1.84e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.67 10.69 0.5 3.99e-23 Body mass index (adult); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08158524 chr12:129308519 SLC15A4 -0.48 -6.47 -0.33 3.44e-10 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg14552801 chr7:65878734 NA 0.44 6.02 0.31 4.68e-9 Aortic root size; LUSC trans rs7937682 0.814 rs1784788 chr11:111486136 T/G cg18187862 chr3:45730750 SACM1L 0.54 7.12 0.36 6.59e-12 Primary sclerosing cholangitis; LUSC cis rs28655083 0.509 rs285024 chr16:77099844 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.38 6.15 0.32 2.24e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.53 -0.38 4.72e-13 Reticulocyte count; LUSC cis rs12620999 0.941 rs10929213 chr2:238020637 A/G cg23555395 chr2:238036564 NA -0.54 -8.93 -0.44 2.88e-17 Systemic lupus erythematosus; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18080401 chr12:49365529 WNT10B 0.4 6.09 0.32 3.13e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg05347473 chr6:146136440 FBXO30 0.41 7.06 0.36 9.96e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs11696501 0.539 rs6073849 chr20:44299385 A/T cg03272292 chr12:48577362 C12orf68 0.5 6.1 0.32 2.93e-9 Brain structure; LUSC cis rs8017423 0.967 rs6575120 chr14:90725094 C/T cg04374321 chr14:90722782 PSMC1 0.75 12.22 0.56 1.25e-28 Mortality in heart failure; LUSC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9818758 0.556 rs13086240 chr3:49001409 G/A cg00383909 chr3:49044727 WDR6 1.3 11.93 0.55 1.42e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs7937682 0.924 rs501089 chr11:111502479 G/T cg19812747 chr11:111475976 SIK2 0.45 6.0 0.31 5.27e-9 Primary sclerosing cholangitis; LUSC cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg12573674 chr2:1569213 NA -0.63 -8.74 -0.43 1.15e-16 IgG glycosylation; LUSC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg02915803 chr1:1606292 LOC728661;CDK11B -0.4 -6.32 -0.33 8.48e-10 Body mass index; LUSC trans rs11098499 0.662 rs13108589 chr4:120268102 G/C cg25214090 chr10:38739885 LOC399744 0.42 6.3 0.33 9.33e-10 Corneal astigmatism; LUSC trans rs62387962 0.649 rs17055032 chr5:157269721 C/A cg09066361 chr7:126890254 GRM8 0.48 6.3 0.33 9.58e-10 Platelet distribution width; LUSC cis rs7215564 0.818 rs35059200 chr17:78661619 T/C cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg23711669 chr6:146136114 FBXO30 0.87 16.3 0.67 2.26e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg21609526 chr1:3105151 PRDM16 -0.29 -5.74 -0.3 2.16e-8 Migraine; LUSC cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg09469691 chr10:81107165 PPIF 0.58 8.75 0.43 1.07e-16 Height; LUSC cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg21770322 chr7:97807741 LMTK2 0.43 7.31 0.37 1.95e-12 Breast cancer; LUSC trans rs2797160 0.904 rs2326292 chr6:125999674 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.72 -0.35 7.69e-11 Endometrial cancer; LUSC cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.45e-28 Intelligence (multi-trait analysis); LUSC cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.19 0.41 5.48e-15 Axial length; LUSC cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg05283184 chr6:79620031 NA -0.58 -12.14 -0.55 2.34e-28 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg11645453 chr3:52864694 ITIH4 0.34 7.92 0.4 3.46e-14 Bipolar disorder; LUSC cis rs250677 0.522 rs4562031 chr5:148368451 A/G cg18129178 chr5:148520854 ABLIM3 0.54 7.59 0.38 3.13e-13 Breast cancer; LUSC cis rs138229 0.506 rs138233 chr22:50559953 G/A cg16473166 chr22:50639996 SELO 0.47 5.66 0.3 3.22e-8 Behavioural disinhibition (generation interaction); LUSC cis rs9300255 0.569 rs1716170 chr12:123716513 C/T cg05973401 chr12:123451056 ABCB9 0.53 6.59 0.34 1.73e-10 Neutrophil percentage of white cells; LUSC cis rs6700896 0.500 rs12043254 chr1:66131707 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1395 1.000 rs7593448 chr2:27449293 C/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.39 6.43 0.33 4.44e-10 Blood metabolite levels; LUSC cis rs9788682 0.748 rs569207 chr15:78873119 A/G cg24631222 chr15:78858424 CHRNA5 -0.65 -8.14 -0.41 7.95e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7589342 0.929 rs7590652 chr2:106440306 A/G cg16077055 chr2:106428750 NCK2 0.36 6.82 0.35 4.29e-11 Addiction; LUSC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg02951883 chr7:2050386 MAD1L1 -0.54 -9.83 -0.47 3.41e-20 Schizophrenia; LUSC cis rs11711311 1.000 rs9863050 chr3:113508888 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.32 0.33 8.39e-10 IgG glycosylation; LUSC cis rs4242434 0.854 rs4872007 chr8:22538879 G/A cg03733263 chr8:22462867 KIAA1967 -0.87 -14.08 -0.61 1.11e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg00945038 chr17:61921165 SMARCD2 0.53 9.55 0.46 2.95e-19 Prudent dietary pattern; LUSC trans rs459571 0.959 rs465724 chr9:136910097 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.41 -5.98 -0.31 5.59e-9 Platelet distribution width; LUSC cis rs11640533 1.000 rs11640533 chr16:53412862 A/G cg02380802 chr16:53407808 NA -0.42 -6.48 -0.33 3.32e-10 Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs11982213 chr7:91722966 A/G cg01689657 chr7:91764605 CYP51A1 0.33 5.84 0.3 1.23e-8 Breast cancer; LUSC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg16414030 chr3:133502952 NA -0.42 -6.47 -0.33 3.44e-10 Iron status biomarkers; LUSC cis rs13064411 0.735 rs6438158 chr3:113217290 C/T cg18753928 chr3:113234510 CCDC52 -0.51 -7.96 -0.4 2.8e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs16866061 0.962 rs3845840 chr2:225359100 G/A cg12698349 chr2:225449008 CUL3 0.87 13.97 0.61 2.9e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs3768617 0.811 rs12022720 chr1:183017223 A/G ch.1.3577855R chr1:183094577 LAMC1 0.6 8.57 0.42 3.97e-16 Fuchs's corneal dystrophy; LUSC cis rs6121246 0.567 rs6058187 chr20:30190923 T/C cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg11812906 chr14:75593930 NEK9 0.66 11.47 0.53 6.48e-26 Height; LUSC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg23630131 chr7:65973040 NA -0.21 -5.74 -0.3 2.13e-8 Aortic root size; LUSC cis rs1023500 0.552 rs5758566 chr22:42454354 G/A cg15557168 chr22:42548783 NA -0.42 -6.49 -0.33 3.16e-10 Schizophrenia; LUSC cis rs6696846 1.000 rs6696846 chr1:205041952 C/T cg21643547 chr1:205240462 TMCC2 -0.39 -7.05 -0.36 1.02e-11 Red blood cell count; LUSC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg12560992 chr17:57184187 TRIM37 0.81 15.09 0.64 1.3e-39 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg16405210 chr4:1374714 KIAA1530 -0.61 -9.82 -0.47 3.67e-20 Longevity; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs6961069 0.901 rs13236689 chr7:80236014 T/G cg04458919 chr7:80252533 CD36 -0.35 -6.53 -0.34 2.52e-10 Platelet count; LUSC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 6.31 0.33 8.7e-10 Personality dimensions; LUSC cis rs9660992 0.736 rs72745207 chr1:205251991 C/G cg00857998 chr1:205179979 DSTYK 0.61 9.23 0.45 3.19e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12541635 0.677 rs61002083 chr8:106982132 A/G cg10147462 chr8:107024639 NA 0.66 13.5 0.59 1.99e-33 Age of smoking initiation; LUSC cis rs2486288 0.656 rs1706768 chr15:45569443 T/C cg09092052 chr15:45571596 NA 0.47 6.56 0.34 2.04e-10 Glomerular filtration rate; LUSC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs12200560 0.505 rs9400166 chr6:97077101 G/A cg06623918 chr6:96969491 KIAA0776 0.5 7.21 0.37 3.75e-12 Coronary heart disease; LUSC cis rs9325144 0.560 rs2387924 chr12:38662883 A/G cg26384229 chr12:38710491 ALG10B -0.67 -10.52 -0.5 1.46e-22 Morning vs. evening chronotype; LUSC cis rs12295403 0.964 rs61886869 chr11:18688508 C/T cg09887367 chr11:18690185 NA -0.34 -7.01 -0.36 1.33e-11 Ovarian reserve; LUSC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg09044154 chr16:88155775 NA -0.55 -7.35 -0.37 1.54e-12 Menopause (age at onset); LUSC trans rs2243480 1.000 rs13237037 chr7:65997882 T/C cg10756647 chr7:56101905 PSPH 0.89 9.05 0.44 1.19e-17 Diabetic kidney disease; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg11645453 chr3:52864694 ITIH4 0.37 8.61 0.43 2.99e-16 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03583524 chr22:38239812 ANKRD54 0.49 6.43 0.33 4.33e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.563 rs2425088 chr20:34303902 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.56 -0.42 4.24e-16 Total cholesterol levels; LUSC cis rs1348850 0.668 rs4893971 chr2:178495743 T/C cg22681709 chr2:178499509 PDE11A -0.46 -7.47 -0.38 7.26e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10927875 0.619 rs2102664 chr1:16130169 A/G cg21385522 chr1:16154831 NA -0.61 -9.85 -0.47 2.99e-20 Dilated cardiomyopathy; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg00024416 chr22:24240387 NA 0.33 5.79 0.3 1.66e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6469656 1.000 rs7007250 chr8:117801441 T/A cg24004040 chr8:117650383 NA 0.42 5.68 0.3 2.89e-8 Colorectal cancer; LUSC cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg06784218 chr1:46089804 CCDC17 0.33 6.01 0.31 4.8e-9 Platelet count; LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg13395646 chr4:1353034 KIAA1530 -0.6 -9.48 -0.46 4.73e-19 Longevity; LUSC cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg05347473 chr6:146136440 FBXO30 0.55 9.38 0.46 1.04e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.48 -0.42 7.41e-16 Menopause (age at onset); LUSC cis rs7072216 0.763 rs6584198 chr10:100169906 G/C cg26618903 chr10:100175079 PYROXD2 -0.47 -8.86 -0.44 4.94e-17 Metabolite levels; LUSC cis rs2692947 0.695 rs12464148 chr2:96596710 G/C cg23100626 chr2:96804247 ASTL 0.23 5.75 0.3 2.05e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.81e-28 Intelligence (multi-trait analysis); LUSC cis rs1018836 0.851 rs7014073 chr8:91618548 T/C cg16814680 chr8:91681699 NA -0.79 -13.33 -0.59 8.29e-33 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1823874 0.924 rs4965542 chr15:100356619 A/G cg16400843 chr15:100339927 C15orf51 0.41 8.29 0.41 2.75e-15 IgG glycosylation; LUSC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg05294307 chr14:35346193 BAZ1A -0.61 -7.4 -0.38 1.15e-12 Psoriasis; LUSC cis rs2749592 0.918 rs1208653 chr10:38253826 C/G cg25427524 chr10:38739819 LOC399744 0.54 7.96 0.4 2.77e-14 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9527 0.535 rs4917999 chr10:104963051 C/G cg05855489 chr10:104503620 C10orf26 -0.56 -8.63 -0.43 2.55e-16 Arsenic metabolism; LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.49 8.29 0.41 2.72e-15 Intelligence (multi-trait analysis); LUSC trans rs1941687 0.563 rs2032189 chr18:31332200 T/A cg27147174 chr7:100797783 AP1S1 -0.56 -8.84 -0.44 5.71e-17 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC trans rs17807624 0.702 rs7815172 chr8:11453671 T/C cg15556689 chr8:8085844 FLJ10661 0.47 6.82 0.35 4.39e-11 Systemic lupus erythematosus; LUSC cis rs9503598 0.778 rs1328688 chr6:3468508 G/A cg00476032 chr6:3446245 SLC22A23 0.39 7.72 0.39 1.38e-13 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg03646922 chr17:4167316 ANKFY1 -0.38 -6.65 -0.34 1.21e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.58 0.67 1.84e-45 Platelet count; LUSC cis rs4654899 0.758 rs6689852 chr1:21341051 T/C cg01072550 chr1:21505969 NA -0.53 -8.16 -0.41 7.06e-15 Superior frontal gyrus grey matter volume; LUSC cis rs10504073 0.669 rs12548464 chr8:50023867 C/T cg00325661 chr8:49890786 NA 0.61 10.34 0.49 6.28e-22 Blood metabolite ratios; LUSC cis rs2635047 0.967 rs2684843 chr18:44726260 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.72 0.35 7.96e-11 Educational attainment; LUSC cis rs7681440 0.874 rs1372523 chr4:90775923 G/A cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.23e-8 Dementia with Lewy bodies; LUSC cis rs10791097 0.748 rs2282579 chr11:130735482 C/T cg12179176 chr11:130786555 SNX19 0.83 14.43 0.62 5.16e-37 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg23158103 chr7:148848205 ZNF398 -0.48 -7.98 -0.4 2.33e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6977660 1.000 rs6973890 chr7:19820497 T/C cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg24130564 chr14:104152367 KLC1 -0.43 -6.08 -0.32 3.34e-9 Body mass index; LUSC trans rs2048656 0.635 rs7830613 chr8:9649769 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.16 -0.32 2.04e-9 Schizophrenia; LUSC cis rs11250464 0.736 rs5015512 chr10:1411923 T/C cg26394196 chr10:1453818 ADARB2 -0.37 -6.35 -0.33 7.22e-10 Radiation response; LUSC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg14440974 chr22:39074834 NA -0.36 -5.96 -0.31 6.56e-9 Menopause (age at onset); LUSC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.47 7.81 0.39 7.35e-14 Vitiligo; LUSC cis rs61931739 0.553 rs68124042 chr12:34064431 C/A cg06521331 chr12:34319734 NA -0.47 -7.67 -0.39 1.89e-13 Morning vs. evening chronotype; LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 14.48 0.62 3.37e-37 Platelet count; LUSC cis rs1485394 0.778 rs2280448 chr12:53896984 G/A cg20730629 chr12:53886622 MAP3K12 -0.46 -5.91 -0.31 8.49e-9 Electroencephalogram traits; LUSC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg11244672 chr19:19639970 YJEFN3 -0.58 -7.38 -0.37 1.27e-12 Bipolar disorder; LUSC cis rs713477 0.967 rs34652660 chr14:55919480 C/A cg13175173 chr14:55914753 NA -0.3 -6.21 -0.32 1.59e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg12437481 chr16:420112 MRPL28 0.46 8.27 0.41 3.17e-15 Bone mineral density (spine);Bone mineral density; LUSC cis rs7772486 0.790 rs2254288 chr6:146204470 G/A cg23711669 chr6:146136114 FBXO30 0.89 16.81 0.68 2.18e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs8017423 0.935 rs11159959 chr14:90733656 C/T cg14092571 chr14:90743983 NA 0.37 5.76 0.3 1.86e-8 Mortality in heart failure; LUSC trans rs7538876 0.903 rs6681150 chr1:17750685 G/A cg13009662 chr5:127419527 SLC12A2;FLJ33630 0.41 6.02 0.31 4.53e-9 Basal cell carcinoma; LUSC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg00031303 chr3:195681400 NA 0.67 9.4 0.46 8.94e-19 Pancreatic cancer; LUSC cis rs9372253 0.843 rs28721292 chr6:110719631 T/C cg19196401 chr6:110721138 DDO -0.46 -8.62 -0.43 2.78e-16 Platelet distribution width; LUSC cis rs710216 0.917 rs710223 chr1:43411038 C/G cg03128534 chr1:43423976 SLC2A1 0.51 6.45 0.33 3.9e-10 Red cell distribution width; LUSC cis rs61931739 0.500 rs35391785 chr12:34444478 C/T cg06521331 chr12:34319734 NA -0.4 -6.3 -0.33 9.13e-10 Morning vs. evening chronotype; LUSC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg06484146 chr7:12443880 VWDE -0.72 -7.24 -0.37 3.15e-12 Coronary artery disease; LUSC cis rs2806561 0.578 rs6702719 chr1:23302576 T/C cg19743168 chr1:23544995 NA 0.39 7.14 0.36 5.75e-12 Height; LUSC cis rs3096299 0.900 rs4785663 chr16:89434888 G/A cg06640241 chr16:89574553 SPG7 0.72 11.35 0.53 1.88e-25 Multiple myeloma (IgH translocation); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20798677 chr17:39968547 FKBP10;SC65 -0.48 -6.46 -0.33 3.63e-10 Bipolar disorder and schizophrenia; LUSC cis rs4243830 0.850 rs4908912 chr1:6599558 A/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -9.64 -0.47 1.4e-19 Body mass index; LUSC cis rs2742417 0.967 rs1534875 chr3:45741043 T/G cg04837898 chr3:45731254 SACM1L -0.34 -5.65 -0.3 3.43e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -6.51 -0.34 2.8e-10 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg00071950 chr4:10020882 SLC2A9 -0.49 -8.17 -0.41 6.57e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs1814175 0.817 rs10769648 chr11:50013992 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs10992471 0.756 rs3758229 chr9:95078852 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -7.78 -0.39 9.04e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7264396 0.563 rs2425071 chr20:34292961 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.64 8.49 0.42 6.67e-16 Total cholesterol levels; LUSC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg13395646 chr4:1353034 KIAA1530 -0.6 -9.4 -0.46 8.77e-19 Longevity; LUSC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg10523679 chr1:76189770 ACADM 0.83 11.47 0.53 6.46e-26 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg01616529 chr11:638424 DRD4 -0.35 -6.02 -0.31 4.64e-9 Systemic lupus erythematosus; LUSC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg08048268 chr3:133502702 NA -0.46 -8.87 -0.44 4.36e-17 Iron status biomarkers; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg02018176 chr4:1364513 KIAA1530 0.54 9.57 0.46 2.55e-19 Longevity; LUSC cis rs6121246 0.529 rs6060144 chr20:30178624 A/G cg18721089 chr20:30220636 NA -0.41 -6.06 -0.31 3.77e-9 Mean corpuscular hemoglobin; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10254974 chr17:16342133 NCRNA00188;SNORD49B;SNORD49A 0.41 6.02 0.31 4.67e-9 Triglycerides; LUSC cis rs9467773 1.000 rs9467778 chr6:26534743 T/C cg05738196 chr6:26577821 NA 0.82 15.82 0.65 1.9e-42 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19970425 chr15:55581976 RAB27A -0.42 -5.99 -0.31 5.52e-9 Bipolar disorder and schizophrenia; LUSC cis rs9399135 0.967 rs7766189 chr6:135353851 A/C cg22676075 chr6:135203613 NA 0.46 7.27 0.37 2.56e-12 Red blood cell count; LUSC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 5.75 0.3 2.02e-8 Personality dimensions; LUSC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg26659404 chr1:25747437 RHCE -0.28 -5.74 -0.3 2.1e-8 Plateletcrit;Mean corpuscular volume; LUSC cis rs2354432 0.556 rs2883319 chr1:146838177 A/G cg25205988 chr1:146714368 CHD1L -0.89 -7.57 -0.38 3.65e-13 Mitochondrial DNA levels; LUSC cis rs7843479 0.601 rs11781959 chr8:21841863 C/G cg17168535 chr8:21777572 XPO7 0.85 15.69 0.65 5.73e-42 Mean corpuscular volume; LUSC cis rs7772486 0.875 rs864390 chr6:146315035 G/T cg23711669 chr6:146136114 FBXO30 0.85 15.11 0.64 1.11e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.12 -0.41 9.13e-15 Lung cancer; LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.16 0.55 2.09e-28 Prudent dietary pattern; LUSC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg15813090 chr5:442598 EXOC3;C5orf55 0.37 6.16 0.32 2.11e-9 Cystic fibrosis severity; LUSC cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg26314531 chr2:26401878 FAM59B -0.67 -9.29 -0.45 2.03e-18 Gut microbiome composition (summer); LUSC cis rs568617 0.768 rs12225345 chr11:65647105 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.61 7.2 0.37 4.07e-12 Crohn's disease; LUSC cis rs727505 1.000 rs10233385 chr7:124498707 C/G cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC trans rs8002861 0.664 rs9567292 chr13:44444816 A/G cg12856521 chr11:46389249 DGKZ 0.44 6.49 0.33 3.11e-10 Leprosy; LUSC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg07414643 chr4:187882934 NA 0.57 10.8 0.51 1.61e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs8113142 0.614 rs73023299 chr19:29207298 T/G cg04546413 chr19:29218101 NA 0.47 6.27 0.32 1.09e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs7592578 0.679 rs62181018 chr2:191323295 C/T cg11845111 chr2:191398756 TMEM194B -0.83 -11.14 -0.52 1e-24 Diastolic blood pressure; LUSC cis rs2404602 0.692 rs3110382 chr15:77148688 G/A cg26408565 chr15:76604113 ETFA 0.46 7.32 0.37 1.84e-12 Blood metabolite levels; LUSC trans rs61931739 0.500 rs11053280 chr12:34559297 G/T cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.58 0.34 1.87e-10 Renal cell carcinoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22779477 chr10:127408223 C10orf137 -0.41 -6.09 -0.32 3.03e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg06194479 chr1:118472240 GDAP2;WDR3 0.36 5.94 0.31 7e-9 Asthma; LUSC cis rs67478160 0.634 rs941473 chr14:104201869 C/G cg08213375 chr14:104286397 PPP1R13B 0.43 8.28 0.41 3.05e-15 Schizophrenia; LUSC cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg02017074 chr12:117425053 FBXW8 0.66 7.77 0.39 9.54e-14 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs9929218 0.954 rs9923925 chr16:68819444 G/A cg02972257 chr16:68554789 NA 0.42 5.85 0.3 1.19e-8 Colorectal cancer; LUSC cis rs3617 0.573 rs12638968 chr3:52919447 T/A cg18099408 chr3:52552593 STAB1 0.36 6.04 0.31 4.2e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs10752881 0.743 rs10737244 chr1:183098417 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Colorectal cancer; LUSC cis rs9300255 0.537 rs1619561 chr12:123620268 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -5.96 -0.31 6.58e-9 Neutrophil percentage of white cells; LUSC cis rs240110 0.525 rs6917195 chr6:101277926 C/T cg09795085 chr6:101329169 ASCC3 0.44 6.18 0.32 1.82e-9 Neuroticism; LUSC cis rs6696846 0.740 rs17344537 chr1:205091427 T/G cg21545522 chr1:205238299 TMCC2 0.46 8.52 0.42 5.56e-16 Red blood cell count; LUSC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.68 10.47 0.5 2.27e-22 Monocyte percentage of white cells; LUSC cis rs7552167 0.925 rs3932664 chr1:24511663 G/T cg01960748 chr1:24522592 NA -0.7 -10.87 -0.51 9.08e-24 Psoriasis vulgaris; LUSC cis rs6964587 1.000 rs9691325 chr7:91731047 G/A cg01689657 chr7:91764605 CYP51A1 0.31 5.66 0.3 3.26e-8 Breast cancer; LUSC cis rs7605378 0.658 rs4673507 chr2:200710167 G/C cg17644776 chr2:200775616 C2orf69 0.49 7.97 0.4 2.55e-14 Osteoporosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20001219 chr13:99101692 FARP1 0.42 5.94 0.31 7.04e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg26314531 chr2:26401878 FAM59B -0.73 -10.21 -0.49 1.79e-21 Gut microbiome composition (summer); LUSC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.21 -0.49 1.74e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs8060686 0.563 rs118005841 chr16:68157562 A/T cg05110241 chr16:68378359 PRMT7 -0.55 -6.05 -0.31 3.81e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg20243544 chr17:37824526 PNMT 0.49 6.88 0.35 3.02e-11 Asthma; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg23034840 chr1:205782522 SLC41A1 0.57 7.9 0.4 3.97e-14 Menarche (age at onset); LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs6987853 0.761 rs2974356 chr8:42434633 C/T cg09913449 chr8:42400586 C8orf40 0.53 9.23 0.45 3.26e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -8.52 -0.42 5.65e-16 Type 2 diabetes; LUSC cis rs2797685 1.000 rs1689904 chr1:7890801 C/T cg04725166 chr1:7887271 PER3 -0.45 -6.4 -0.33 5.4e-10 Crohn's disease; LUSC cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg13319975 chr6:146136371 FBXO30 -0.43 -6.34 -0.33 7.64e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs6545883 0.862 rs778141 chr2:61682178 A/G cg15711740 chr2:61764176 XPO1 -0.43 -6.41 -0.33 5.01e-10 Tuberculosis; LUSC cis rs9303401 0.659 rs12602389 chr17:56779778 G/A cg25039879 chr17:56429692 SUPT4H1 0.68 9.14 0.45 6.1e-18 Cognitive test performance; LUSC cis rs6754311 0.593 rs10186843 chr2:136586958 C/A cg25344623 chr2:136566232 LCT 0.39 5.94 0.31 6.99e-9 Mosquito bite size; LUSC trans rs1998174 0.509 rs1118173 chr1:171830704 C/T cg13482142 chr2:234261155 NA 0.42 6.09 0.32 3.11e-9 Platelet distribution width; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg06538774 chr22:24584247 SUSD2 -0.38 -6.1 -0.32 2.86e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs488628 1.000 rs540615 chr3:118138699 A/C cg06621744 chr14:37052470 NKX2-8 -0.29 -6.68 -0.34 1.02e-10 White matter integrity (bipolar disorder risk interaction); LUSC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg06641503 chr3:48959341 ARIH2 -0.38 -5.77 -0.3 1.83e-8 Parkinson's disease; LUSC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.19 -0.41 5.67e-15 Intelligence (multi-trait analysis); LUSC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11644478 chr21:40555479 PSMG1 -0.62 -9.49 -0.46 4.7e-19 Menarche (age at onset); LUSC cis rs5758511 0.773 rs12167978 chr22:42346475 G/A cg12850546 chr22:42539477 CYP2D7P1 -0.49 -6.02 -0.31 4.65e-9 Birth weight; LUSC cis rs2072499 0.778 rs2842868 chr1:156196407 A/C cg24450063 chr1:156163899 SLC25A44 1.04 16.52 0.67 3.21e-45 Testicular germ cell tumor; LUSC cis rs9467160 0.734 rs35901848 chr6:24443640 G/A cg20631270 chr6:24437470 GPLD1 0.44 6.1 0.32 2.99e-9 Liver enzyme levels; LUSC cis rs941898 0.574 rs8006662 chr14:100577890 C/T cg26002632 chr14:100625216 DEGS2 0.33 5.64 0.3 3.56e-8 White matter hyperintensity burden; LUSC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg13607699 chr17:42295918 UBTF 0.56 8.53 0.42 5.32e-16 Total body bone mineral density; LUSC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg23188684 chr11:67383651 NA 0.35 6.33 0.33 7.98e-10 Mean corpuscular volume; LUSC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg06484146 chr7:12443880 VWDE -0.73 -7.34 -0.37 1.64e-12 Coronary artery disease; LUSC cis rs826838 0.616 rs4418873 chr12:38625473 C/A cg13010199 chr12:38710504 ALG10B 0.48 7.28 0.37 2.47e-12 Heart rate; LUSC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg04287289 chr16:89883240 FANCA 0.77 6.21 0.32 1.57e-9 Skin colour saturation; LUSC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg09323728 chr8:95962352 TP53INP1 -0.38 -7.71 -0.39 1.48e-13 Type 2 diabetes; LUSC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.73 -0.3 2.21e-8 Vitiligo; LUSC cis rs55883249 1.000 rs62119429 chr2:9743585 G/C cg23886495 chr2:9695866 ADAM17 0.49 5.78 0.3 1.71e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22105146 chr4:56262445 TMEM165 -0.42 -6.56 -0.34 2.06e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10144321 0.903 rs4905958 chr14:100924288 A/G cg14882082 chr14:100845427 WDR25 -0.42 -8.11 -0.41 9.73e-15 Menarche (age at onset); LUSC cis rs10751667 0.621 rs11246345 chr11:934924 T/C ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC trans rs7495211 0.529 rs11247366 chr15:98624159 T/A cg08901157 chr15:56033728 PRTG 0.35 6.2 0.32 1.7e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs727505 0.754 rs55859595 chr7:124783083 G/T cg23710748 chr7:124431027 NA -0.41 -7.13 -0.36 6.25e-12 Lewy body disease; LUSC cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg04414720 chr1:150670196 GOLPH3L -0.44 -7.03 -0.36 1.16e-11 Tonsillectomy; LUSC cis rs7582180 0.614 rs4340543 chr2:101005511 G/A cg12002119 chr2:101014098 CHST10 0.38 6.39 0.33 5.68e-10 Intelligence (multi-trait analysis); LUSC cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg16584290 chr5:462447 EXOC3 0.46 8.15 0.41 7.32e-15 Cystic fibrosis severity; LUSC cis rs7424096 0.555 rs75219072 chr2:37225706 C/T cg14987922 chr2:37194071 STRN 0.61 8.21 0.41 4.87e-15 High light scatter reticulocyte percentage of red cells; LUSC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 10.8 0.51 1.65e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1559088 0.600 rs7246566 chr19:33589618 A/T cg03563238 chr19:33554763 RHPN2 -0.37 -6.34 -0.33 7.24e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg11530693 chr1:120165357 ZNF697 0.69 10.79 0.51 1.79e-23 Systemic lupus erythematosus; LUSC cis rs6542838 0.641 rs6760065 chr2:99486318 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.36 -0.33 6.61e-10 Fear of minor pain; LUSC trans rs8072100 0.790 rs1962307 chr17:45707871 A/G cg03886242 chr7:26192032 NFE2L3 -0.39 -6.02 -0.31 4.72e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2261181 0.803 rs2612065 chr12:66172771 G/C cg19918230 chr2:219745647 WNT10A -0.54 -5.98 -0.31 5.88e-9 Type 2 diabetes; LUSC cis rs870825 0.616 rs28375770 chr4:185647395 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg08754478 chr10:133766260 PPP2R2D -0.64 -8.16 -0.41 6.69e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.73 0.39 1.3e-13 Electroencephalogram traits; LUSC cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg05043794 chr9:111880884 C9orf5 -0.34 -7.2 -0.37 3.89e-12 Menarche (age at onset); LUSC cis rs8014204 0.544 rs2286913 chr14:75386576 G/A cg11812906 chr14:75593930 NEK9 0.39 5.76 0.3 1.91e-8 Caffeine consumption; LUSC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg26839252 chr6:160211577 TCP1;MRPL18 0.46 6.11 0.32 2.81e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg20503657 chr10:835505 NA 0.78 9.74 0.47 6.96e-20 Eosinophil percentage of granulocytes; LUSC trans rs2562456 0.833 rs4644962 chr19:21520927 C/T cg00806126 chr19:22604979 ZNF98 -0.43 -6.21 -0.32 1.6e-9 Pain; LUSC cis rs56176327 0.600 rs7628207 chr3:49754970 T/C cg13072238 chr3:49761600 GMPPB -0.63 -7.95 -0.4 2.93e-14 Intelligence (multi-trait analysis); LUSC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.77 0.51 2.08e-23 Hip circumference adjusted for BMI; LUSC cis rs10276381 0.786 rs10281102 chr7:28243473 A/G cg23620719 chr7:28220237 JAZF1 0.64 6.7 0.34 8.86e-11 Crohn's disease; LUSC cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.45 -0.42 8.92e-16 Schizophrenia; LUSC cis rs10779751 0.734 rs2791650 chr1:11132541 G/C cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs5769765 0.955 rs8138687 chr22:50291869 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.04 0.36 1.07e-11 Schizophrenia; LUSC cis rs9296092 0.517 rs7743445 chr6:33470600 G/T cg13560919 chr6:33536144 NA -0.78 -13.33 -0.59 8.65e-33 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7954584 0.551 rs1169072 chr12:122401501 C/T cg22618164 chr12:122356400 WDR66 -0.5 -7.22 -0.37 3.64e-12 Mean corpuscular volume; LUSC cis rs9300255 0.602 rs1402274 chr12:123686224 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.58 0.34 1.85e-10 Neutrophil percentage of white cells; LUSC cis rs1018836 0.923 rs1858674 chr8:91580665 G/T cg16814680 chr8:91681699 NA -0.74 -12.09 -0.55 3.73e-28 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg18402987 chr7:1209562 NA 0.7 8.02 0.4 1.78e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg20503657 chr10:835505 NA 0.99 14.2 0.61 3.83e-36 Eosinophil percentage of granulocytes; LUSC cis rs7980687 0.628 rs2102949 chr12:123676763 G/A cg00376283 chr12:123451042 ABCB9 0.69 9.71 0.47 8.35e-20 Height;Educational attainment;Head circumference (infant); LUSC trans rs2898290 0.622 rs7829381 chr8:11344573 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.35 -0.33 7.06e-10 Systolic blood pressure; LUSC cis rs7223966 0.921 rs6504186 chr17:61863932 G/A cg00945038 chr17:61921165 SMARCD2 0.4 6.03 0.31 4.3e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7216064 1.000 rs7221651 chr17:65832390 A/G cg12091567 chr17:66097778 LOC651250 0.71 8.95 0.44 2.49e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.54 -0.38 4.33e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00415308 chr7:77427774 PHTF2;TMEM60 0.41 6.25 0.32 1.26e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10879418 chr16:81479272 CMIP -0.46 -6.13 -0.32 2.43e-9 Hepatitis; LUSC cis rs11971779 0.590 rs6467839 chr7:139062790 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.18 0.32 1.85e-9 Diisocyanate-induced asthma; LUSC cis rs7089973 0.668 rs7898347 chr10:116644324 G/A cg25233709 chr10:116636983 FAM160B1 0.37 6.18 0.32 1.87e-9 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9837602 1.000 rs9864437 chr3:99764754 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.09 -0.32 3.14e-9 Breast cancer; LUSC cis rs11190604 1.000 rs10509744 chr10:102271579 C/T cg23241863 chr10:102295624 HIF1AN 0.47 5.71 0.3 2.49e-8 Palmitoleic acid (16:1n-7) levels; LUSC trans rs1945213 0.694 rs34390414 chr11:55863367 T/G cg15704280 chr7:45808275 SEPT13 0.74 8.4 0.42 1.26e-15 Acute lymphoblastic leukemia (childhood); LUSC trans rs853679 0.546 rs71537572 chr6:27970715 T/C cg09904177 chr6:26538194 HMGN4 -0.78 -6.06 -0.31 3.58e-9 Depression; LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.47 0.33 3.44e-10 Platelet count; LUSC cis rs1003719 0.715 rs2251952 chr21:38559711 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -9.99 -0.48 9.79e-21 Eye color traits; LUSC cis rs16937 0.711 rs11240388 chr1:205177617 G/A cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs7786808 0.564 rs10267128 chr7:158198490 G/A cg09998033 chr7:158218633 PTPRN2 0.48 7.59 0.38 3.2e-13 Obesity-related traits; LUSC cis rs17401966 0.931 rs12137880 chr1:10388620 T/C cg19773385 chr1:10388646 KIF1B -0.58 -10.05 -0.48 6.12e-21 Hepatocellular carcinoma; LUSC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg06238570 chr21:40685208 BRWD1 0.48 7.49 0.38 6.18e-13 Cognitive function; LUSC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg11843238 chr5:131593191 PDLIM4 -0.38 -6.07 -0.32 3.54e-9 Breast cancer; LUSC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.75 13.7 0.6 3.4e-34 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.46 0.53 7.26e-26 Menopause (age at onset); LUSC cis rs1595825 0.945 rs73056880 chr2:198822292 G/A cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 6.08e-9 Ulcerative colitis; LUSC cis rs41271473 0.948 rs11585206 chr1:228824848 C/T cg16512390 chr1:228756714 NA 0.54 6.22 0.32 1.5e-9 Chronic lymphocytic leukemia; LUSC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg13902645 chr11:5959945 NA -0.6 -8.44 -0.42 9.71e-16 DNA methylation (variation); LUSC cis rs10203711 1.000 rs13028091 chr2:239569723 C/T cg14580085 chr2:239553406 NA 0.42 7.11 0.36 7.05e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1143633 0.579 rs3811042 chr2:113670834 G/A cg06156847 chr2:113672199 IL1F7 0.28 6.02 0.31 4.65e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs76878669 0.561 rs4930178 chr11:66129442 C/G cg24851651 chr11:66362959 CCS -0.36 -5.73 -0.3 2.25e-8 Educational attainment (years of education); LUSC cis rs2652834 1.000 rs2652833 chr15:63396885 C/A cg05507819 chr15:63340323 TPM1 0.68 8.27 0.41 3.21e-15 HDL cholesterol; LUSC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg18681998 chr4:17616180 MED28 0.84 15.29 0.64 2.27e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17604090 1.000 rs28591682 chr7:29690811 T/C cg19413766 chr7:29689036 LOC646762 -0.64 -7.69 -0.39 1.69e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs9486719 0.843 rs2472875 chr6:96844691 G/A cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs854765 0.547 rs2955353 chr17:17948979 T/C cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.55e-11 Total body bone mineral density; LUSC cis rs950169 0.840 rs62029595 chr15:84955301 C/T cg17507749 chr15:85114479 UBE2QP1 0.65 8.25 0.41 3.75e-15 Schizophrenia; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.94 -12.67 -0.57 2.62e-30 Alzheimer's disease; LUSC cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg24642439 chr20:33292090 TP53INP2 -0.49 -7.36 -0.37 1.44e-12 Glomerular filtration rate (creatinine); LUSC cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg06627557 chr7:32535165 LSM5;AVL9 1.0 17.05 0.68 2.4e-47 Cognitive ability; LUSC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg26335602 chr6:28129616 ZNF389 0.43 5.8 0.3 1.54e-8 Depression; LUSC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15541040 chr2:3486749 NA -0.57 -8.8 -0.43 7.23e-17 Neurofibrillary tangles; LUSC cis rs4268898 0.662 rs74470633 chr2:24438712 A/G cg06627628 chr2:24431161 ITSN2 -0.88 -13.32 -0.59 9.52e-33 Asthma; LUSC cis rs9398803 0.865 rs9401882 chr6:126755055 A/G cg19875578 chr6:126661172 C6orf173 0.41 6.11 0.32 2.81e-9 Male-pattern baldness; LUSC cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg12386194 chr3:101231763 SENP7 -0.43 -6.33 -0.33 7.76e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs983392 0.678 rs1426253 chr11:59981218 A/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.96 -0.31 6.46e-9 Alzheimer's disease (late onset); LUSC cis rs1568889 1.000 rs61889026 chr11:28274803 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 8.82 0.43 6.31e-17 Bipolar disorder; LUSC trans rs3733585 0.673 rs4455410 chr4:9953297 C/T cg26043149 chr18:55253948 FECH 0.42 6.42 0.33 4.78e-10 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs911119 1.000 rs13039536 chr20:23612305 A/G cg16589663 chr20:23618590 CST3 0.59 6.87 0.35 3.15e-11 Chronic kidney disease; LUSC cis rs1577917 0.916 rs12661611 chr6:86553835 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -6.17 -0.32 1.97e-9 Response to antipsychotic treatment; LUSC cis rs11758351 0.866 rs56186759 chr6:26207181 C/T cg01420254 chr6:26195488 NA 0.64 7.28 0.37 2.35e-12 Gout;Renal underexcretion gout; LUSC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg00825309 chr19:58991885 ZNF446 -0.5 -7.23 -0.37 3.37e-12 Uric acid clearance; LUSC cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.91 -0.35 2.4e-11 Menopause (age at onset); LUSC cis rs4285028 0.731 rs2332035 chr3:121715432 C/T cg20356878 chr3:121714668 ILDR1 -0.45 -6.31 -0.33 9.09e-10 Multiple sclerosis; LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg26314531 chr2:26401878 FAM59B 0.74 10.13 0.48 3.38e-21 Gut microbiome composition (summer); LUSC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC trans rs11098499 0.863 rs11098531 chr4:120465001 G/A cg25214090 chr10:38739885 LOC399744 0.54 7.98 0.4 2.39e-14 Corneal astigmatism; LUSC cis rs713477 0.967 rs7146170 chr14:55914054 G/C cg13175173 chr14:55914753 NA -0.31 -6.49 -0.33 3.05e-10 Pediatric bone mineral content (femoral neck); LUSC trans rs11098499 0.954 rs59394118 chr4:120295551 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.0 0.31 5.02e-9 Corneal astigmatism; LUSC cis rs231513 0.954 rs231500 chr17:41973374 T/C cg26893861 chr17:41843967 DUSP3 -0.5 -6.07 -0.32 3.42e-9 Cognitive function; LUSC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg05623727 chr3:50126028 RBM5 0.31 5.82 0.3 1.37e-8 Intelligence (multi-trait analysis); LUSC cis rs2235544 0.565 rs633315 chr1:54468689 G/A cg25741118 chr1:54482237 LDLRAD1 0.28 5.98 0.31 5.61e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs7089973 0.624 rs11196930 chr10:116583596 C/T cg03647239 chr10:116582469 FAM160B1 0.45 7.19 0.37 4.38e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg02423579 chr7:2872169 GNA12 -0.45 -6.62 -0.34 1.42e-10 Height; LUSC cis rs7582720 1.000 rs72926796 chr2:203827480 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1215050 0.791 rs2865943 chr4:98778449 C/T cg05340658 chr4:99064831 C4orf37 0.43 6.71 0.34 8.57e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9467711 0.790 rs34107459 chr6:26328353 T/C cg16898833 chr6:26189333 HIST1H4D 0.78 6.03 0.31 4.37e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9467711 0.584 rs34244947 chr6:26761745 T/C cg09904177 chr6:26538194 HMGN4 -0.76 -5.7 -0.3 2.63e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs11676348 0.772 rs6738953 chr2:218950036 C/A cg00012203 chr2:219082015 ARPC2 -0.51 -7.88 -0.4 4.72e-14 Ulcerative colitis; LUSC cis rs10131894 0.611 rs174995 chr14:75434183 T/C cg11812906 chr14:75593930 NEK9 -0.53 -8.67 -0.43 1.94e-16 Coronary artery disease; LUSC cis rs10193935 1.000 rs4048 chr2:42424595 A/C cg27598129 chr2:42591480 NA -0.66 -8.69 -0.43 1.7e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6121246 0.697 rs6060446 chr20:30231637 T/C cg13852791 chr20:30311386 BCL2L1 0.83 10.26 0.49 1.16e-21 Mean corpuscular hemoglobin; LUSC cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg24642439 chr20:33292090 TP53INP2 0.69 10.66 0.5 5.11e-23 Coronary artery disease; LUSC cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg02782426 chr3:40428986 ENTPD3 0.33 6.15 0.32 2.21e-9 Renal cell carcinoma; LUSC trans rs11992162 0.613 rs6601634 chr8:11806456 T/C cg06636001 chr8:8085503 FLJ10661 -0.48 -6.79 -0.35 5.1e-11 Monocyte count; LUSC cis rs4776059 0.958 rs35505902 chr15:52888493 A/G cg22715398 chr15:52968154 KIAA1370 -0.71 -10.09 -0.48 4.56e-21 Schizophrenia; LUSC cis rs7826238 0.509 rs2948288 chr8:8115304 A/G cg11608241 chr8:8085544 FLJ10661 0.44 6.32 0.33 8.37e-10 Systolic blood pressure; LUSC cis rs1697139 0.583 rs11739587 chr5:66540481 A/C cg11553311 chr5:66541588 NA -0.31 -5.86 -0.31 1.09e-8 Breast cancer; LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg10729496 chr3:10149963 C3orf24 0.56 7.55 0.38 4.22e-13 Alzheimer's disease; LUSC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg17385448 chr1:15911702 AGMAT 0.37 6.23 0.32 1.42e-9 Systolic blood pressure; LUSC cis rs6460942 0.630 rs17671056 chr7:12390961 C/G cg06484146 chr7:12443880 VWDE -0.57 -5.87 -0.31 1.05e-8 Coronary artery disease; LUSC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg08219700 chr8:58056026 NA 0.66 7.44 0.38 8.4e-13 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.69 0.47 1.01e-19 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.863 rs6858592 chr4:120458692 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.71 0.39 1.46e-13 Corneal astigmatism; LUSC cis rs4727027 0.870 rs11524138 chr7:148799125 G/A cg23583168 chr7:148888333 NA -0.87 -15.87 -0.66 1.17e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.64 0.63 8.06e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.11 0.32 2.75e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs12188164 0.686 rs72711367 chr5:418494 A/G cg15371732 chr17:78194151 SLC26A11;SGSH 0.41 6.27 0.32 1.13e-9 Cystic fibrosis severity; LUSC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg12963246 chr6:28129442 ZNF389 0.5 6.8 0.35 4.94e-11 Depression; LUSC cis rs17490626 0.568 rs12413525 chr10:71211721 C/A cg12610070 chr10:71211762 TSPAN15 -0.49 -9.43 -0.46 7e-19 Thrombosis; LUSC cis rs11169552 0.510 rs4768899 chr12:51000666 T/A cg12884762 chr12:50931848 DIP2B -0.31 -5.66 -0.3 3.23e-8 Colorectal cancer; LUSC cis rs2637266 0.783 rs10824437 chr10:78469493 C/T cg18941641 chr10:78392320 NA 0.35 6.32 0.33 8.42e-10 Pulmonary function; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11513088 chr12:26111821 RASSF8 -0.42 -6.04 -0.31 4.12e-9 Electrocardiographic conduction measures; LUSC cis rs4474465 1.000 rs7124092 chr11:78155086 T/C cg27205649 chr11:78285834 NARS2 -0.51 -6.08 -0.32 3.31e-9 Alzheimer's disease (survival time); LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg17541715 chr7:1216824 NA -0.37 -5.88 -0.31 9.89e-9 Longevity;Endometriosis; LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -7.42 -0.38 9.48e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs61931739 0.517 rs7486246 chr12:34526419 T/G cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs7584330 0.780 rs7582828 chr2:238378476 A/C cg14458575 chr2:238380390 NA -0.64 -11.54 -0.53 3.64e-26 Prostate cancer; LUSC cis rs7107174 0.748 rs11237458 chr11:78050849 A/T cg02023728 chr11:77925099 USP35 0.44 6.7 0.34 8.71e-11 Testicular germ cell tumor; LUSC cis rs500891 0.574 rs3798891 chr6:84117293 C/A cg08257003 chr6:84140564 ME1 0.36 8.74 0.43 1.14e-16 Platelet-derived growth factor BB levels; LUSC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg21573476 chr21:45109991 RRP1B -0.39 -6.26 -0.32 1.21e-9 Mean corpuscular volume; LUSC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg22029157 chr1:209979665 IRF6 0.73 8.97 0.44 2.23e-17 Cleft lip with or without cleft palate; LUSC cis rs1728785 0.901 rs698715 chr16:68560896 A/G cg02972257 chr16:68554789 NA -0.5 -6.36 -0.33 6.76e-10 Ulcerative colitis; LUSC cis rs1728785 0.901 rs698715 chr16:68560896 A/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.75 -0.3 2e-8 Ulcerative colitis; LUSC cis rs7605827 0.930 rs6722963 chr2:15527105 C/T cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs6840360 0.593 rs10022023 chr4:152560731 A/G cg22705602 chr4:152727874 NA -0.31 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs7824557 0.843 rs2572418 chr8:11113089 G/A cg21775007 chr8:11205619 TDH -0.54 -8.02 -0.4 1.82e-14 Retinal vascular caliber; LUSC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg16797656 chr11:68205561 LRP5 -0.4 -7.29 -0.37 2.26e-12 Total body bone mineral density; LUSC cis rs34779708 0.833 rs12777517 chr10:35473927 T/G cg04310649 chr10:35416472 CREM -0.42 -6.43 -0.33 4.4e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7178572 0.568 rs11853460 chr15:77515319 C/T cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.1 0.41 1.07e-14 Intelligence (multi-trait analysis); LUSC cis rs500891 0.525 rs2096223 chr6:84077446 T/G cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs981844 1.000 rs56232929 chr4:154665700 A/G cg14289246 chr4:154710475 SFRP2 0.47 5.86 0.31 1.14e-8 Response to statins (LDL cholesterol change); LUSC cis rs892961 0.777 rs747483 chr17:75412091 C/T cg05865280 chr17:75406074 SEPT9 0.45 9.46 0.46 5.89e-19 Airflow obstruction; LUSC cis rs425277 1.000 rs262654 chr1:2089526 G/A cg03732007 chr1:2071316 PRKCZ 0.46 7.36 0.37 1.48e-12 Height; LUSC cis rs3755132 0.852 rs56002839 chr2:15790440 G/A cg12888861 chr2:15731646 DDX1 0.48 7.11 0.36 7.01e-12 Wilms tumor; LUSC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -8.6 -0.43 3.13e-16 Hemoglobin concentration; LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg16405210 chr4:1374714 KIAA1530 0.71 11.0 0.52 3.21e-24 Obesity-related traits; LUSC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg05855489 chr10:104503620 C10orf26 -0.62 -8.09 -0.4 1.15e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs367615 0.704 rs17161885 chr5:108852642 A/G cg17395555 chr5:108820864 NA 0.62 11.08 0.52 1.59e-24 Colorectal cancer (SNP x SNP interaction); LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg14004847 chr7:1930337 MAD1L1 -0.56 -8.71 -0.43 1.46e-16 Bipolar disorder and schizophrenia; LUSC cis rs8077889 0.700 rs28571770 chr17:41904066 A/T cg26893861 chr17:41843967 DUSP3 0.86 13.17 0.58 3.36e-32 Triglycerides; LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg10802521 chr3:52805072 NEK4 -0.48 -7.54 -0.38 4.41e-13 Cognitive function; LUSC cis rs4727027 0.870 rs1534196 chr7:148790591 G/A cg23583168 chr7:148888333 NA -0.85 -15.6 -0.65 1.33e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2730245 0.527 rs62476464 chr7:158698063 C/T cg24397884 chr7:158709396 WDR60 0.8 9.04 0.44 1.31e-17 Height; LUSC cis rs17818399 0.620 rs6544906 chr2:46863872 A/C cg21493583 chr2:46842958 PIGF;CRIPT 0.34 6.12 0.32 2.63e-9 Height; LUSC cis rs950776 0.518 rs4886571 chr15:78833758 G/A cg06917634 chr15:78832804 PSMA4 -0.82 -14.55 -0.62 1.77e-37 Sudden cardiac arrest; LUSC trans rs7681440 0.904 rs7672979 chr4:90767873 A/G cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs8179 0.645 rs56201652 chr7:92278116 G/A cg15732164 chr7:92237376 CDK6 -0.4 -6.01 -0.31 4.86e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.44 6.0 0.31 5.27e-9 Tonsillectomy; LUSC cis rs2797160 1.000 rs1935773 chr6:125996475 A/G cg05901451 chr6:126070800 HEY2 -0.59 -8.88 -0.44 4.04e-17 Endometrial cancer; LUSC cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg08999081 chr20:33150536 PIGU -0.5 -9.63 -0.47 1.52e-19 Glomerular filtration rate (creatinine); LUSC cis rs977987 0.843 rs6564259 chr16:75447393 T/G cg03315344 chr16:75512273 CHST6 0.48 8.92 0.44 3.16e-17 Dupuytren's disease; LUSC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg07234876 chr8:600039 NA -0.9 -8.86 -0.44 4.9e-17 IgG glycosylation; LUSC cis rs5771242 0.518 rs7290465 chr22:50679758 C/T cg16473166 chr22:50639996 SELO -0.7 -9.88 -0.48 2.28e-20 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); LUSC cis rs9372253 0.678 rs9372251 chr6:110700656 A/G cg19196401 chr6:110721138 DDO -0.41 -7.67 -0.39 1.88e-13 Platelet distribution width; LUSC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg03526776 chr6:41159608 TREML2 0.34 6.65 0.34 1.19e-10 Alzheimer's disease (late onset); LUSC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg12463550 chr7:65579703 CRCP -0.52 -7.35 -0.37 1.5e-12 Aortic root size; LUSC cis rs1728785 0.892 rs1170427 chr16:68603852 G/T cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC cis rs2797160 0.967 rs984041 chr6:126021328 A/T cg05901451 chr6:126070800 HEY2 0.57 8.76 0.43 1.03e-16 Endometrial cancer; LUSC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg05082376 chr22:42548792 NA -0.41 -6.32 -0.33 8.57e-10 Schizophrenia; LUSC cis rs7241530 0.662 rs55745067 chr18:75902055 A/G cg14642773 chr18:75888474 NA 0.41 6.27 0.32 1.14e-9 Educational attainment (years of education); LUSC cis rs6570726 0.935 rs391820 chr6:145821284 C/T cg23711669 chr6:146136114 FBXO30 0.73 12.89 0.58 3.92e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg19717773 chr7:2847554 GNA12 0.41 6.91 0.35 2.51e-11 Height; LUSC cis rs61931739 0.534 rs1384860 chr12:34045388 T/C cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.05e-15 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -1.19 -29.28 -0.85 2.92e-94 Chronic sinus infection; LUSC cis rs35306767 0.623 rs56201968 chr10:1141666 A/G cg20503657 chr10:835505 NA 0.48 6.2 0.32 1.67e-9 Eosinophil percentage of granulocytes; LUSC cis rs929596 0.564 rs2602364 chr2:234524229 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.41 -0.33 4.85e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg26395211 chr5:140044315 WDR55 0.46 7.1 0.36 7.64e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg11843238 chr5:131593191 PDLIM4 0.4 6.67 0.34 1.04e-10 Breast cancer; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg00945038 chr17:61921165 SMARCD2 0.53 8.91 0.44 3.28e-17 Prudent dietary pattern; LUSC cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg11657440 chr19:46296263 DMWD -0.73 -11.19 -0.52 6.89e-25 Coronary artery disease; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.66 10.84 0.51 1.19e-23 Lymphocyte counts; LUSC cis rs2730245 0.527 rs62476462 chr7:158686619 A/G cg24397884 chr7:158709396 WDR60 0.8 8.96 0.44 2.34e-17 Height; LUSC cis rs10089 0.951 rs56066100 chr5:127460571 G/C cg19767477 chr5:127420684 SLC12A2 -0.42 -5.65 -0.3 3.46e-8 Ileal carcinoids; LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg08677398 chr8:58056175 NA 0.53 7.05 0.36 1.04e-11 Developmental language disorder (linguistic errors); LUSC cis rs6456156 0.792 rs10946215 chr6:167516181 A/G cg07741184 chr6:167504864 NA -0.39 -6.94 -0.35 2.07e-11 Primary biliary cholangitis; LUSC trans rs877282 0.945 rs71491303 chr10:772884 G/T cg13042288 chr15:90349979 ANPEP -0.48 -6.77 -0.35 5.86e-11 Uric acid levels; LUSC cis rs9300255 0.639 rs941306 chr12:123715113 C/T cg00376283 chr12:123451042 ABCB9 0.65 8.3 0.41 2.63e-15 Neutrophil percentage of white cells; LUSC cis rs72781680 0.950 rs72798404 chr2:24180125 C/T cg20701182 chr2:24300061 SF3B14 0.78 7.8 0.39 7.8500000000000006e-14 Lymphocyte counts; LUSC cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg14530993 chr4:882597 GAK 0.72 7.41 0.38 1.07e-12 Intelligence (multi-trait analysis); LUSC trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.87 -0.35 3.18e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg06046430 chr4:77819534 ANKRD56 0.48 6.88 0.35 2.88e-11 Emphysema distribution in smoking; LUSC cis rs11719291 0.667 rs9877542 chr3:48748545 C/T cg00383909 chr3:49044727 WDR6 1.12 10.38 0.49 4.73e-22 Cognitive function; LUSC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg12639453 chr1:2035780 PRKCZ -0.3 -6.32 -0.33 8.39e-10 Height; LUSC cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.18 0.55 1.66e-28 Motion sickness; LUSC trans rs11700980 0.551 rs11701783 chr21:30115629 C/G cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs6121246 0.528 rs6060252 chr20:30191084 A/G cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg23791538 chr6:167370224 RNASET2 -0.41 -6.54 -0.34 2.25e-10 Crohn's disease; LUSC cis rs66887589 0.592 rs28580295 chr4:120278873 C/T cg09307838 chr4:120376055 NA 0.57 8.56 0.42 4.04e-16 Diastolic blood pressure; LUSC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg06238570 chr21:40685208 BRWD1 -0.62 -10.31 -0.49 8e-22 Cognitive function; LUSC cis rs11711311 1.000 rs28394480 chr3:113485143 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 7.13 0.36 6.3e-12 IgG glycosylation; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg05700333 chr5:131892723 RAD50 -0.47 -6.27 -0.32 1.12e-9 Height; LUSC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg00745463 chr17:30367425 LRRC37B -0.7 -8.34 -0.42 1.98e-15 Hip circumference adjusted for BMI; LUSC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC trans rs9951602 0.512 rs9958376 chr18:76655167 G/T cg02800362 chr5:177631904 HNRNPAB 0.87 12.81 0.57 8.07e-31 Obesity-related traits; LUSC cis rs11214589 0.747 rs10891536 chr11:113209428 C/G cg14159747 chr11:113255604 NA 0.24 5.8 0.3 1.51e-8 Neuroticism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21744723 chr5:34839210 TTC23L 0.72 6.23 0.32 1.4e-9 Cognitive performance; LUSC cis rs4561483 0.734 rs33655 chr16:11970381 C/T cg08843971 chr16:11963173 GSPT1 -0.47 -7.03 -0.36 1.14e-11 Testicular germ cell tumor; LUSC cis rs4077515 0.527 rs10870146 chr9:139308054 G/A cg14019695 chr9:139328340 INPP5E 0.5 9.64 0.47 1.41e-19 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg23277830 chr1:3704460 LRRC47 0.3 5.73 0.3 2.22e-8 Red cell distribution width; LUSC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC cis rs2404602 0.692 rs55864032 chr15:77122548 A/G cg23625390 chr15:77176239 SCAPER 0.46 6.87 0.35 3.09e-11 Blood metabolite levels; LUSC trans rs12677056 0.746 rs61189440 chr8:113314753 T/G cg12159992 chr12:102059490 MYBPC1 0.36 5.98 0.31 5.78e-9 Peripheral artery disease; LUSC cis rs12145833 0.665 rs78871868 chr1:243422322 C/T cg02356786 chr1:243265016 LOC731275 0.68 6.23 0.32 1.41e-9 Obesity (early onset extreme); LUSC cis rs6543140 0.865 rs6760275 chr2:103079607 C/T cg09003973 chr2:102972529 NA 0.54 6.87 0.35 3.16e-11 Blood protein levels; LUSC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg23711669 chr6:146136114 FBXO30 0.89 17.09 0.68 1.64e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs1018697 0.966 rs1953930 chr10:104549461 G/A cg04362960 chr10:104952993 NT5C2 0.48 6.64 0.34 1.25e-10 Colorectal adenoma (advanced); LUSC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg02269571 chr22:50332266 NA 0.59 8.72 0.43 1.32e-16 Schizophrenia; LUSC cis rs13064411 0.696 rs7624994 chr3:113228009 T/C cg18753928 chr3:113234510 CCDC52 -0.5 -7.69 -0.39 1.66e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs9457247 0.565 rs12178491 chr6:167512474 C/T cg07741184 chr6:167504864 NA 0.5 8.84 0.44 5.46e-17 Crohn's disease; LUSC trans rs6502050 0.871 rs6502055 chr17:80070868 G/T cg07393940 chr7:158741817 NA -0.36 -6.43 -0.33 4.3e-10 Life satisfaction; LUSC cis rs617219 0.698 rs10514159 chr5:78596044 T/C cg24856658 chr5:78533917 JMY 0.29 5.8 0.3 1.55e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs612683 0.518 rs660945 chr1:100831830 A/T cg06223162 chr1:101003688 GPR88 -0.39 -7.25 -0.37 2.88e-12 Breast cancer; LUSC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg11062466 chr8:58055876 NA 0.48 6.03 0.31 4.34e-9 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg11663144 chr21:46675770 NA -0.39 -6.76 -0.35 6.33e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs477692 0.905 rs485579 chr10:131425492 T/G cg26102564 chr10:131424627 MGMT 0.37 5.88 0.31 9.79e-9 Response to temozolomide; LUSC trans rs3857536 0.842 rs2188591 chr6:66939511 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs11955175 1.000 rs78426328 chr5:40673176 G/T cg05478818 chr5:40835740 RPL37 0.72 5.95 0.31 6.65e-9 Bipolar disorder and schizophrenia; LUSC trans rs1728785 0.901 rs1645934 chr16:68564490 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs7264396 0.790 rs2425115 chr20:34322418 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.36 -0.46 1.24e-18 Total cholesterol levels; LUSC cis rs4851254 0.660 rs9784000 chr2:100697201 G/C cg07810366 chr2:100720526 AFF3 -0.44 -5.9 -0.31 8.91e-9 Intelligence (multi-trait analysis); LUSC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg11812906 chr14:75593930 NEK9 0.63 11.22 0.52 5.32e-25 Height; LUSC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg01448562 chr3:133502909 NA -0.66 -10.9 -0.51 7.41e-24 Iron status biomarkers; LUSC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg21918786 chr6:109611834 NA -0.37 -6.25 -0.32 1.28e-9 Reticulocyte fraction of red cells; LUSC cis rs11577318 0.528 rs11247935 chr1:26698622 G/C cg00852783 chr1:26633632 UBXN11 -0.55 -7.54 -0.38 4.61e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs11690462 0.528 rs1344734 chr2:26637068 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.48 6.11 0.32 2.78e-9 Coronary artery disease; LUSC cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.9 -0.35 2.6e-11 Menopause (age at onset); LUSC trans rs9929218 1.000 rs13334326 chr16:68809207 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.72 -0.54 8.62e-27 Colorectal cancer; LUSC cis rs3755132 0.929 rs6743630 chr2:15768256 G/A cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC trans rs3749237 1.000 rs2291542 chr3:49751585 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.53 7.56 0.38 3.9e-13 Resting heart rate; LUSC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg13535736 chr9:111863775 C9orf5 -0.4 -6.76 -0.35 6.01e-11 Menarche (age at onset); LUSC cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg19052272 chr2:3704530 ALLC 0.59 10.68 0.5 4.17e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9341808 0.754 rs3805925 chr6:80883833 T/C cg08355045 chr6:80787529 NA 0.58 10.07 0.48 5.31e-21 Sitting height ratio; LUSC cis rs17155006 0.746 rs420753 chr7:107746253 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg04727924 chr7:799746 HEATR2 -0.59 -6.26 -0.32 1.15e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.46 0.5 2.54e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg00944433 chr1:107599041 PRMT6 -0.39 -7.06 -0.36 9.62e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs2404602 0.692 rs8037005 chr15:76951109 C/T cg23625390 chr15:77176239 SCAPER 0.47 7.23 0.37 3.25e-12 Blood metabolite levels; LUSC cis rs870825 0.616 rs7678616 chr4:185648714 T/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.74 8.65 0.43 2.15e-16 Schizophrenia; LUSC cis rs1371867 0.875 rs1612773 chr8:101337818 G/C cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.26e-11 Atrioventricular conduction; LUSC cis rs9359856 1.000 rs9359856 chr6:90307985 A/G cg13799429 chr6:90582589 CASP8AP2 -0.59 -7.0 -0.36 1.4e-11 Bipolar disorder; LUSC cis rs34779708 0.966 rs12775759 chr10:35400183 G/T cg04310649 chr10:35416472 CREM -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg16606324 chr3:10149918 C3orf24 -0.67 -9.19 -0.45 4.26e-18 Alzheimer's disease; LUSC cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.81 0.3 1.44e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1858037 0.867 rs4671658 chr2:65561392 A/G cg08085232 chr2:65598271 SPRED2 0.41 6.18 0.32 1.83e-9 Rheumatoid arthritis; LUSC cis rs2708977 0.966 rs749027 chr2:97203137 A/C cg01950434 chr2:97203154 ARID5A -0.57 -8.55 -0.42 4.5e-16 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs765787 0.530 rs2554457 chr15:45520926 G/A cg25801113 chr15:45476975 SHF 0.35 7.09 0.36 8.23e-12 Uric acid levels; LUSC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg17252645 chr8:143867129 LY6D 0.38 6.62 0.34 1.41e-10 Urinary tract infection frequency; LUSC cis rs9473147 0.543 rs9349417 chr6:47580657 A/G cg12968598 chr6:47444699 CD2AP 0.53 8.1 0.41 1.06e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.78 0.6 1.66e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg08807101 chr21:30365312 RNF160 0.8 15.59 0.65 1.49e-41 Dental caries; LUSC cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.96e-12 Motion sickness; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg16145915 chr7:1198662 ZFAND2A -0.52 -9.5 -0.46 4.05e-19 Longevity;Endometriosis; LUSC cis rs4803468 0.967 rs892044 chr19:41903671 A/G cg09537434 chr19:41945824 ATP5SL -0.89 -15.81 -0.65 2.07e-42 Height; LUSC cis rs1322512 0.917 rs2623956 chr6:152971617 G/A cg27316956 chr6:152958899 SYNE1 -0.33 -5.91 -0.31 8.44e-9 Tonometry; LUSC cis rs911119 0.908 rs8121147 chr20:23601708 T/C cg16589663 chr20:23618590 CST3 0.59 7.08 0.36 8.56e-12 Chronic kidney disease; LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs733592 0.965 rs1978161 chr12:48467721 A/G cg24011408 chr12:48396354 COL2A1 -0.43 -7.22 -0.37 3.61e-12 Plateletcrit; LUSC cis rs3768617 0.510 rs1413389 chr1:183096668 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs17125944 0.773 rs1952089 chr14:53339777 C/T cg00686598 chr14:53173677 PSMC6 -0.65 -6.01 -0.31 4.85e-9 Alzheimer's disease (late onset); LUSC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg09904177 chr6:26538194 HMGN4 -0.53 -6.18 -0.32 1.91e-9 Intelligence (multi-trait analysis); LUSC cis rs7107174 1.000 rs2256187 chr11:77919768 G/A cg02023728 chr11:77925099 USP35 0.52 6.91 0.35 2.52e-11 Testicular germ cell tumor; LUSC cis rs477692 0.669 rs12265939 chr10:131445398 A/G cg05714579 chr10:131428358 MGMT -0.65 -10.25 -0.49 1.33e-21 Response to temozolomide; LUSC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.13 0.32 2.46e-9 Menopause (age at onset); LUSC cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg21535247 chr6:8435926 SLC35B3 0.59 9.24 0.45 3.06e-18 Motion sickness; LUSC trans rs3733585 0.624 rs76574510 chr4:9953252 T/A cg26043149 chr18:55253948 FECH -0.45 -6.9 -0.35 2.59e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9372253 1.000 rs9386894 chr6:110718853 A/G cg01119278 chr6:110721349 DDO -0.49 -8.76 -0.43 9.88e-17 Platelet distribution width; LUSC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg12963246 chr6:28129442 ZNF389 0.51 7.07 0.36 9.01e-12 Depression; LUSC cis rs6723226 0.572 rs176411 chr2:32643528 A/G cg02381751 chr2:32503542 YIPF4 0.51 8.08 0.4 1.18e-14 Intelligence (multi-trait analysis); LUSC cis rs668210 0.793 rs506873 chr11:65767215 A/C cg02202077 chr11:65769826 EIF1AD;BANF1 -0.53 -7.12 -0.36 6.78e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs13006833 0.668 rs2664252 chr2:191148347 G/A cg21644426 chr2:191273491 MFSD6 0.45 6.51 0.34 2.69e-10 Urinary metabolites; LUSC cis rs9788682 1.000 rs12441354 chr15:78821016 G/A cg06917634 chr15:78832804 PSMA4 -0.58 -7.11 -0.36 7.01e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6494488 0.500 rs72742916 chr15:64850675 T/A cg08069370 chr15:64387884 SNX1 -0.64 -5.73 -0.3 2.24e-8 Coronary artery disease; LUSC cis rs17270561 0.585 rs9393663 chr6:25741033 A/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.59 0.38 3.15e-13 Iron status biomarkers; LUSC trans rs2832077 0.943 rs11700746 chr21:30189207 T/C cg14791747 chr16:20752902 THUMPD1 0.73 9.55 0.46 2.84e-19 Cognitive test performance; LUSC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg10253484 chr15:75165896 SCAMP2 0.5 7.47 0.38 7.21e-13 Breast cancer; LUSC cis rs12579753 0.872 rs12319937 chr12:82182545 T/G cg07988820 chr12:82153109 PPFIA2 -0.4 -5.72 -0.3 2.32e-8 Resting heart rate; LUSC cis rs7804356 1.000 rs73065521 chr7:26831409 C/A cg03456212 chr7:26904342 SKAP2 -0.55 -6.52 -0.34 2.66e-10 Type 1 diabetes; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg05131254 chr6:138188363 TNFAIP3 0.4 6.28 0.32 1.06e-9 Educational attainment (years of education); LUSC trans rs7647973 0.593 rs55997059 chr3:49858661 A/T cg21659725 chr3:3221576 CRBN 0.72 8.83 0.44 6.22e-17 Menarche (age at onset); LUSC cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg27446573 chr6:127587934 RNF146 0.92 15.35 0.64 1.35e-40 Breast cancer; LUSC cis rs4803468 0.967 rs4605279 chr19:41888131 C/G cg09537434 chr19:41945824 ATP5SL -0.87 -15.45 -0.65 5.48e-41 Height; LUSC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg00990874 chr7:1149470 C7orf50 -0.56 -6.53 -0.34 2.43e-10 Bronchopulmonary dysplasia; LUSC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg11941060 chr3:133502564 NA -0.52 -8.14 -0.41 7.76e-15 Iron status biomarkers; LUSC cis rs10504229 0.679 rs16921683 chr8:58053270 T/C cg08219700 chr8:58056026 NA 0.46 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); LUSC cis rs10751667 0.857 rs6597961 chr11:976677 T/C ch.11.42038R chr11:967971 AP2A2 0.55 8.3 0.41 2.69e-15 Alzheimer's disease (late onset); LUSC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg14552801 chr7:65878734 NA 0.44 6.27 0.32 1.12e-9 Aortic root size; LUSC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg14668632 chr7:2872130 GNA12 -0.5 -7.45 -0.38 7.99e-13 Height; LUSC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg18512352 chr11:47633146 NA -0.46 -9.22 -0.45 3.55e-18 Subjective well-being; LUSC cis rs2688608 0.967 rs2675663 chr10:75660270 T/G cg23231163 chr10:75533350 FUT11 -0.37 -5.96 -0.31 6.34e-9 Inflammatory bowel disease; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg15383120 chr6:291909 DUSP22 0.66 11.14 0.52 1.02e-24 Menopause (age at onset); LUSC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg01503450 chr10:980765 NA -0.39 -5.79 -0.3 1.59e-8 Eosinophil percentage of granulocytes; LUSC cis rs9929218 0.954 rs7186333 chr16:68815838 T/A cg02972257 chr16:68554789 NA 0.41 5.74 0.3 2.13e-8 Colorectal cancer; LUSC cis rs6681460 0.834 rs2916 chr1:67216697 G/A cg02459107 chr1:67143332 SGIP1 -0.47 -8.35 -0.42 1.81e-15 Presence of antiphospholipid antibodies; LUSC cis rs9653442 0.564 rs12992234 chr2:100767886 G/A cg07810366 chr2:100720526 AFF3 -0.43 -7.31 -0.37 2.03e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs317689 0.513 rs317659 chr12:69686132 T/A cg11871910 chr12:69753446 YEATS4 0.61 9.47 0.46 5.44e-19 Response to diuretic therapy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23713156 chr17:80606235 WDR45L -0.48 -6.22 -0.32 1.48e-9 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.933 rs11836175 chr12:86311644 A/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.19 -0.32 1.78e-9 Major depressive disorder; LUSC cis rs61612642 0.590 rs6931028 chr6:42193064 A/T cg01092361 chr6:42185687 MRPS10 0.78 8.49 0.42 6.66e-16 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg11965913 chr1:205819406 PM20D1 -0.55 -8.92 -0.44 3.23e-17 Menarche (age at onset); LUSC cis rs2290159 0.800 rs56363132 chr3:12680403 T/C cg23032965 chr3:12705835 RAF1 0.74 9.13 0.45 6.87e-18 Cholesterol, total; LUSC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg12927641 chr6:109611667 NA -0.35 -5.9 -0.31 8.81e-9 Reticulocyte fraction of red cells; LUSC cis rs6545883 0.826 rs2694651 chr2:61588642 T/C cg15711740 chr2:61764176 XPO1 0.42 6.28 0.33 1.04e-9 Tuberculosis; LUSC cis rs459571 0.635 rs379471 chr9:136890649 G/A cg13789015 chr9:136890014 NCRNA00094 0.7 12.69 0.57 2.29e-30 Platelet distribution width; LUSC trans rs1814175 0.712 rs9665784 chr11:50030617 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs1775715 0.737 rs1541260 chr10:32105570 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.68e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6964587 1.000 rs2282975 chr7:91761638 A/G cg17063962 chr7:91808500 NA 0.6 9.55 0.46 2.87e-19 Breast cancer; LUSC cis rs12701220 0.894 rs10263252 chr7:1049949 G/A cg26769984 chr7:1090371 C7orf50 0.69 9.94 0.48 1.44e-20 Bronchopulmonary dysplasia; LUSC cis rs4906332 1.000 rs78316803 chr14:103942863 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -7.15 -0.36 5.46e-12 Coronary artery disease; LUSC cis rs1448094 0.967 rs6539934 chr12:86343973 G/A cg00310523 chr12:86230176 RASSF9 0.37 6.77 0.35 5.65e-11 Major depressive disorder; LUSC cis rs10089 1.000 rs7713877 chr5:127428825 G/T cg19767477 chr5:127420684 SLC12A2 -0.42 -5.88 -0.31 9.9e-9 Ileal carcinoids; LUSC cis rs1823874 0.720 rs7162911 chr15:100355050 A/G cg16400843 chr15:100339927 C15orf51 0.35 7.02 0.36 1.25e-11 IgG glycosylation; LUSC cis rs713587 0.571 rs564667 chr2:25310860 A/T cg01884057 chr2:25150051 NA -0.27 -5.84 -0.3 1.25e-8 Body mass index in non-asthmatics; LUSC cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.85 -0.35 3.49e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7267979 1.000 rs2259928 chr20:25281834 G/C cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10791097 0.694 rs11222369 chr11:130744670 A/G cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg05707623 chr12:122985044 ZCCHC8 -0.66 -8.33 -0.41 2.14e-15 Body mass index; LUSC trans rs4332037 0.539 rs56016347 chr7:2060126 C/T cg25206134 chr2:45395956 NA 0.62 7.23 0.37 3.24e-12 Bipolar disorder; LUSC cis rs7267979 1.000 rs761025 chr20:25426968 G/A cg08601574 chr20:25228251 PYGB 0.44 6.79 0.35 5.29e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs16937 0.711 rs3851284 chr1:205156080 A/T cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg11584989 chr19:19387371 SF4 0.57 6.92 0.35 2.31e-11 Bipolar disorder; LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg25036284 chr2:26402008 FAM59B 0.77 11.11 0.52 1.34e-24 Gut microbiome composition (summer); LUSC cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg26384229 chr12:38710491 ALG10B 0.92 15.79 0.65 2.33e-42 Bladder cancer; LUSC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg16447950 chr5:562315 NA -0.59 -7.08 -0.36 8.54e-12 Lung disease severity in cystic fibrosis; LUSC trans rs1325195 0.840 rs2816177 chr1:179248952 A/G cg11624085 chr17:8464688 MYH10 0.44 7.19 0.37 4.29e-12 IgE grass sensitization; LUSC cis rs1003719 0.788 rs2835582 chr21:38458773 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.71 11.44 0.53 8.57e-26 Eye color traits; LUSC cis rs57590327 0.555 rs7634258 chr3:81799100 T/C cg07356753 chr3:81810745 GBE1 -0.67 -10.65 -0.5 5.4e-23 Extraversion; LUSC cis rs35146811 0.555 rs2525539 chr7:99545309 A/G cg22906224 chr7:99728672 NA -0.42 -5.69 -0.3 2.79e-8 Coronary artery disease; LUSC cis rs8114671 0.662 rs6058146 chr20:33540529 A/G cg07148914 chr20:33460835 GGT7 0.48 7.14 0.36 5.69e-12 Height; LUSC trans rs61931739 0.534 rs11053020 chr12:34111092 C/G cg26384229 chr12:38710491 ALG10B 0.71 11.22 0.52 5.05e-25 Morning vs. evening chronotype; LUSC cis rs7647973 0.961 rs62259943 chr3:49425167 A/G cg07636037 chr3:49044803 WDR6 -0.67 -8.62 -0.43 2.79e-16 Menarche (age at onset); LUSC cis rs35995292 0.500 rs28369620 chr7:38921872 C/T cg19327137 chr7:38886074 VPS41 0.55 10.26 0.49 1.21e-21 Subjective well-being (multi-trait analysis); LUSC cis rs9660992 0.710 rs4951184 chr1:205240659 A/T cg21545522 chr1:205238299 TMCC2 0.51 9.85 0.47 2.95e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg18099408 chr3:52552593 STAB1 -0.43 -7.5 -0.38 5.8e-13 Bipolar disorder; LUSC trans rs236907 0.812 rs55732843 chr1:171796962 A/G cg13482142 chr2:234261155 NA 0.51 6.26 0.32 1.21e-9 Mean platelet volume; LUSC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg08219700 chr8:58056026 NA 0.48 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg19717773 chr7:2847554 GNA12 -0.4 -6.06 -0.31 3.58e-9 Height; LUSC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg15352829 chr14:105391018 PLD4 -0.42 -8.79 -0.43 7.86e-17 Rheumatoid arthritis; LUSC cis rs7605827 0.930 rs10164574 chr2:15677258 G/A cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.27e-17 Educational attainment (years of education); LUSC cis rs6714710 0.580 rs57681139 chr2:98454473 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9660992 0.710 rs1151787 chr1:205254238 G/A cg00857998 chr1:205179979 DSTYK 0.62 9.41 0.46 8.36e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6977660 0.714 rs12386623 chr7:19791875 A/G cg05791153 chr7:19748676 TWISTNB -0.77 -8.26 -0.41 3.36e-15 Thyroid stimulating hormone; LUSC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg27170947 chr2:26402098 FAM59B 0.69 9.76 0.47 5.91e-20 Gut microbiome composition (summer); LUSC cis rs977987 0.843 rs8056080 chr16:75410798 C/A cg04384234 chr16:75411784 CFDP1 -0.45 -7.54 -0.38 4.4e-13 Dupuytren's disease; LUSC cis rs9658691 0.607 rs9658788 chr10:90776486 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -6.23 -0.32 1.42e-9 Mosquito bite size; LUSC cis rs2404602 0.569 rs2469249 chr15:76772062 C/T cg26408565 chr15:76604113 ETFA 0.43 6.1 0.32 2.96e-9 Blood metabolite levels; LUSC cis rs5769707 0.632 rs135877 chr22:50014002 A/G cg05373962 chr22:49881684 NA -0.41 -8.55 -0.42 4.58e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg12432903 chr7:1882776 MAD1L1 -0.51 -8.58 -0.42 3.72e-16 Bipolar disorder and schizophrenia; LUSC cis rs9303401 0.659 rs34351230 chr17:56782555 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs9329221 0.572 rs4841295 chr8:10105115 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.08 0.32 3.25e-9 Neuroticism; LUSC cis rs6580649 0.882 rs59766465 chr12:48470169 G/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg20701182 chr2:24300061 SF3B14 0.9 11.53 0.53 4.11e-26 Lymphocyte counts; LUSC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.4 -6.06 -0.31 3.59e-9 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg05863683 chr7:1912471 MAD1L1 0.3 5.93 0.31 7.68e-9 Bipolar disorder and schizophrenia; LUSC trans rs3785574 0.536 rs2854190 chr17:61960219 G/A cg09060275 chr22:27053596 MIAT -0.4 -5.99 -0.31 5.46e-9 Height; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.47 5.75 0.3 2.01e-8 Renal function-related traits (BUN); LUSC trans rs10763170 0.608 rs11004722 chr10:56826608 G/A cg10538533 chr12:53074328 KRT1 0.3 5.98 0.31 5.81e-9 Sporadic pituitary adenoma; LUSC cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg26408565 chr15:76604113 ETFA -0.43 -6.82 -0.35 4.4e-11 Blood metabolite levels; LUSC cis rs7605827 0.930 rs13026732 chr2:15695429 G/A cg19274914 chr2:15703543 NA 0.47 8.85 0.44 5.29e-17 Educational attainment (years of education); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02150654 chr10:122216378 PPAPDC1A -0.5 -6.14 -0.32 2.38e-9 Bipolar disorder and schizophrenia; LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg05368731 chr17:41323189 NBR1 0.93 16.01 0.66 3.23e-43 Menopause (age at onset); LUSC cis rs6964587 1.000 rs28584017 chr7:91719168 G/A cg01689657 chr7:91764605 CYP51A1 0.33 5.84 0.3 1.23e-8 Breast cancer; LUSC trans rs11039798 1.000 rs8188963 chr11:48685693 C/A cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs6940638 0.688 rs2022272 chr6:27103580 A/G cg09904177 chr6:26538194 HMGN4 -0.47 -6.85 -0.35 3.58e-11 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg27535305 chr1:53392650 SCP2 0.37 6.89 0.35 2.78e-11 Monocyte count; LUSC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg13531842 chr10:38383804 ZNF37A -0.44 -6.72 -0.35 7.84e-11 Extrinsic epigenetic age acceleration; LUSC trans rs9291683 0.588 rs3756238 chr4:10013202 C/T cg26043149 chr18:55253948 FECH 0.49 7.28 0.37 2.43e-12 Bone mineral density; LUSC cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg02527881 chr3:46936655 PTH1R -0.42 -7.61 -0.38 2.88e-13 Colorectal cancer; LUSC cis rs4474465 0.688 rs7940507 chr11:78284453 T/C cg27205649 chr11:78285834 NARS2 0.59 7.2 0.37 4.05e-12 Alzheimer's disease (survival time); LUSC cis rs11633958 1 rs11633958 chr15:78862064 C/T cg06917634 chr15:78832804 PSMA4 -0.44 -5.95 -0.31 6.67e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.57e-8 Developmental language disorder (linguistic errors); LUSC trans rs7849782 0.935 rs724556 chr9:104425068 G/T cg22914338 chr19:14376960 NA 0.26 6.37 0.33 6.38e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg04034577 chr2:241836375 C2orf54 -0.49 -9.28 -0.45 2.25e-18 Urinary metabolites; LUSC cis rs11098499 0.675 rs11098534 chr4:120556772 T/G cg09307838 chr4:120376055 NA 0.65 9.87 0.48 2.43e-20 Corneal astigmatism; LUSC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg21665744 chr7:39171113 POU6F2 -0.47 -7.27 -0.37 2.64e-12 IgG glycosylation; LUSC trans rs4729127 1.000 rs57515158 chr7:94007842 T/G cg16531660 chr3:141457093 RNF7 0.56 6.03 0.31 4.26e-9 Intelligence; LUSC cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg18132916 chr6:79620363 NA -0.4 -6.17 -0.32 1.99e-9 Intelligence (multi-trait analysis); LUSC cis rs9611519 1.000 rs3818003 chr22:41609690 C/T cg03806693 chr22:41940476 POLR3H -0.49 -6.78 -0.35 5.59e-11 Neuroticism; LUSC trans rs1973993 1.000 rs1973993 chr1:96943994 A/G cg10631902 chr5:14652156 NA 0.51 8.77 0.43 9.54e-17 Weight; LUSC cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg09537434 chr19:41945824 ATP5SL -0.72 -10.54 -0.5 1.35e-22 Migraine;Coronary artery disease; LUSC cis rs1190552 0.846 rs3783381 chr14:102965435 A/G cg18135206 chr14:102964638 TECPR2 0.48 5.89 0.31 9.54e-9 Blood protein levels; LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg14433983 chr11:636460 DRD4 -0.35 -5.88 -0.31 9.78e-9 Systemic lupus erythematosus; LUSC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg08219700 chr8:58056026 NA 0.68 7.92 0.4 3.51e-14 Developmental language disorder (linguistic errors); LUSC cis rs7429990 0.965 rs319686 chr3:47930420 C/G cg11946769 chr3:48343235 NME6 0.44 5.82 0.3 1.39e-8 Educational attainment (years of education); LUSC cis rs950169 0.887 rs35986397 chr15:84955107 G/A cg12863693 chr15:85201151 NMB 0.36 7.03 0.36 1.15e-11 Schizophrenia; LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs2745967 0.791 rs11118957 chr1:208116590 C/T cg15031826 chr1:208136952 NA 0.41 5.65 0.3 3.48e-8 Resting heart rate; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.91 -0.51 6.79e-24 Alzheimer's disease; LUSC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg21775007 chr8:11205619 TDH -0.45 -6.3 -0.33 9.13e-10 Joint mobility (Beighton score); LUSC cis rs12618769 0.597 rs17032870 chr2:99132786 C/T cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg08807101 chr21:30365312 RNF160 -0.73 -12.82 -0.57 7.16e-31 Dental caries; LUSC cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg13319975 chr6:146136371 FBXO30 0.39 5.78 0.3 1.75e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.74 -12.68 -0.57 2.45e-30 Total body bone mineral density; LUSC cis rs7786808 0.649 rs6459879 chr7:158211792 C/G cg09998033 chr7:158218633 PTPRN2 -0.4 -6.38 -0.33 5.87e-10 Obesity-related traits; LUSC cis rs7903847 0.642 rs11189175 chr10:99139609 T/C cg08345082 chr10:99160200 RRP12 -0.37 -7.46 -0.38 7.51e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg06453172 chr10:134556979 INPP5A -0.5 -6.31 -0.33 8.66e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7640424 0.620 rs71321252 chr3:107813107 A/C cg09227934 chr3:107805635 CD47 -0.55 -7.78 -0.39 9.23e-14 Body mass index; LUSC trans rs9388451 0.839 rs3757217 chr6:126069636 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.61 -9.61 -0.47 1.87e-19 Brugada syndrome; LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg15147215 chr3:52552868 STAB1 -0.34 -6.67 -0.34 1.05e-10 Bipolar disorder; LUSC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg17554472 chr22:41940697 POLR3H -0.46 -5.72 -0.3 2.39e-8 Vitiligo; LUSC trans rs2243480 0.901 rs58207111 chr7:65486723 C/T cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.59e-15 Diabetic kidney disease; LUSC cis rs10791323 0.572 rs1114367 chr11:133737304 G/T cg15485101 chr11:133734466 NA 0.39 7.06 0.36 9.98e-12 Childhood ear infection; LUSC cis rs61931739 1.000 rs12427279 chr12:34025898 T/G cg06521331 chr12:34319734 NA 0.4 6.59 0.34 1.72e-10 Morning vs. evening chronotype; LUSC cis rs2625529 0.730 rs8182011 chr15:72389948 C/T cg16672083 chr15:72433130 SENP8 0.48 7.67 0.39 1.94e-13 Red blood cell count; LUSC cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg06064525 chr11:970664 AP2A2 0.34 6.95 0.36 1.92e-11 Alzheimer's disease (late onset); LUSC cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg00071950 chr4:10020882 SLC2A9 -0.49 -8.26 -0.41 3.57e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.0 -0.48 8.83e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7089973 0.604 rs11196942 chr10:116596872 G/A cg23260525 chr10:116636907 FAM160B1 0.42 9.08 0.44 9.59e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg08888203 chr3:10149979 C3orf24 0.56 8.12 0.41 9.08e-15 Alzheimer's disease; LUSC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg05754148 chr16:3507555 NAT15 -0.57 -8.77 -0.43 9.55e-17 Tuberculosis; LUSC cis rs868036 0.718 rs8030456 chr15:68076856 C/T cg08079166 chr15:68083412 MAP2K5 0.41 7.5 0.38 5.85e-13 Restless legs syndrome; LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.7e-19 Menopause (age at onset); LUSC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs3087591 0.708 rs7350943 chr17:29684553 C/T cg24425628 chr17:29625626 OMG;NF1 0.49 7.21 0.37 3.86e-12 Hip circumference; LUSC cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.967 rs2065978 chr20:33767291 C/T cg24642439 chr20:33292090 TP53INP2 0.4 5.84 0.3 1.22e-8 Height; LUSC cis rs34779708 0.931 rs35388511 chr10:35296616 A/G cg03585969 chr10:35415529 CREM 0.6 8.73 0.43 1.27e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9807989 0.839 rs1974675 chr2:102986375 G/A cg03938978 chr2:103052716 IL18RAP 0.31 5.66 0.3 3.23e-8 Asthma; LUSC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.82 -0.3 1.42e-8 Depression; LUSC cis rs4285028 0.948 rs2091664 chr3:121684749 T/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.68 -0.47 1.07e-19 Multiple sclerosis; LUSC trans rs1015291 0.708 rs10770561 chr12:19999041 C/T cg01501474 chr7:55323552 NA 0.48 6.23 0.32 1.41e-9 Diastolic blood pressure; LUSC cis rs8060686 0.545 rs55897859 chr16:68286748 G/C cg09835421 chr16:68378352 PRMT7 -0.7 -7.06 -0.36 9.98e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs4843185 0.731 rs3815795 chr16:85712105 A/G cg00168118 chr16:85669675 KIAA0182 -0.37 -5.75 -0.3 2.04e-8 Platelet distribution width; LUSC cis rs11032090 1 rs11032090 chr11:4417129 A/G cg08577913 chr11:4415193 TRIM21 0.44 7.01 0.36 1.34e-11 Lung cancer; LUSC cis rs9815354 0.638 rs60525434 chr3:42044286 T/G cg03022575 chr3:42003672 ULK4 0.6 6.43 0.33 4.44e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6502050 0.835 rs4789666 chr17:80162276 C/T cg07393940 chr7:158741817 NA 0.36 6.55 0.34 2.13e-10 Life satisfaction; LUSC cis rs483180 0.531 rs541503 chr1:120208297 A/G cg19096424 chr1:120255104 PHGDH -0.44 -6.15 -0.32 2.16e-9 Macular telangiectasia type 2; LUSC cis rs7615316 0.779 rs2086933 chr3:142039406 G/A cg16271453 chr3:142027066 XRN1 -0.41 -7.12 -0.36 6.57e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs10506458 0.688 rs73127095 chr12:63418283 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.04 -14.0 -0.61 2.32e-35 Hemostatic factors and hematological phenotypes; LUSC cis rs826838 1.000 rs10875717 chr12:38911174 T/C cg26384229 chr12:38710491 ALG10B 0.93 17.43 0.69 7.74e-49 Heart rate; LUSC cis rs4663866 0.901 rs71426512 chr2:239187128 C/T cg16914508 chr2:239161102 PER2 0.69 7.31 0.37 1.94e-12 Irritable bowel syndrome; LUSC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg21724239 chr8:58056113 NA 0.78 8.17 0.41 6.56e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.69 0.54 1.11e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg13535736 chr9:111863775 C9orf5 0.39 6.64 0.34 1.27e-10 Menarche (age at onset); LUSC cis rs752010 0.619 rs10789406 chr1:42105182 G/T cg06885757 chr1:42089581 HIVEP3 -0.47 -9.31 -0.45 1.72e-18 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg06238570 chr21:40685208 BRWD1 -0.64 -10.64 -0.5 5.72e-23 Cognitive function; LUSC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg06008330 chr7:65541103 ASL -0.4 -6.18 -0.32 1.84e-9 Aortic root size; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg19410738 chr19:39226868 CAPN12 0.37 6.16 0.32 2.1e-9 Metabolite levels (Pyroglutamine); LUSC cis rs240764 0.717 rs10872622 chr6:101165017 C/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.08 -0.32 3.25e-9 Neuroticism; LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg10862848 chr6:42927986 GNMT -0.28 -6.75 -0.35 6.42e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 11.08 0.52 1.71e-24 Alzheimer's disease; LUSC cis rs6940638 0.688 rs9393791 chr6:27132529 C/G cg09904177 chr6:26538194 HMGN4 -0.44 -6.26 -0.32 1.17e-9 Intelligence (multi-trait analysis); LUSC cis rs2953174 0.938 rs2975758 chr2:241530750 G/A cg07929629 chr2:241523174 NA 0.45 5.98 0.31 5.87e-9 Bipolar disorder; LUSC cis rs12291225 0.679 rs11369 chr11:14288096 A/G cg19336497 chr11:14380999 RRAS2 -0.57 -12.01 -0.55 7.37e-28 Sense of smell; LUSC trans rs2204008 0.728 rs11495375 chr12:38282631 G/A cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC cis rs3760982 0.585 rs8109478 chr19:44298256 C/T cg11993925 chr19:44307056 LYPD5 0.36 7.75 0.39 1.08e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs2227564 0.700 rs2688612 chr10:75653205 G/T cg23231163 chr10:75533350 FUT11 -0.41 -5.79 -0.3 1.59e-8 Crohn's disease;Inflammatory bowel disease; LUSC trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg15704280 chr7:45808275 SEPT13 0.75 8.45 0.42 9.35e-16 Acute lymphoblastic leukemia (childhood); LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs506338 0.517 rs490192 chr11:64471369 C/T cg19131476 chr11:64387923 NRXN2 0.34 7.25 0.37 2.98e-12 Body mass index;Urate levels; LUSC cis rs7580658 0.963 rs4233583 chr2:128060068 C/A cg09760422 chr2:128146352 NA -0.33 -7.27 -0.37 2.51e-12 Protein C levels; LUSC cis rs11190604 1.000 rs3793772 chr10:102222825 A/G cg16342193 chr10:102329863 NA -0.37 -6.75 -0.35 6.36e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg04398451 chr17:18023971 MYO15A 0.46 7.35 0.37 1.57e-12 Total body bone mineral density; LUSC cis rs11190604 1.000 rs11190592 chr10:102291059 T/C cg23241863 chr10:102295624 HIF1AN 0.48 5.74 0.3 2.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs666930 0.519 rs483180 chr1:120267505 C/G cg19096424 chr1:120255104 PHGDH -0.6 -8.34 -0.42 1.95e-15 Breast cancer; LUSC cis rs7000551 0.751 rs2449348 chr8:22359572 C/T cg12081754 chr8:22256438 SLC39A14 0.4 6.06 0.31 3.76e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs72634258 0.945 rs6577459 chr1:8100173 G/T cg26816564 chr1:7831052 VAMP3 0.5 6.1 0.32 3e-9 Inflammatory bowel disease; LUSC cis rs9814567 0.806 rs4074521 chr3:134325536 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.78 12.64 0.57 3.44e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg24812749 chr6:127587940 RNF146 0.9 13.45 0.59 2.91e-33 Breast cancer; LUSC cis rs11098499 0.954 rs1546505 chr4:120241224 A/G cg09307838 chr4:120376055 NA 0.79 11.12 0.52 1.2e-24 Corneal astigmatism; LUSC cis rs5758659 0.967 rs5758670 chr22:42636687 T/C cg05082376 chr22:42548792 NA -0.4 -6.56 -0.34 2.08e-10 Cognitive function; LUSC cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg16006841 chr5:176797999 RGS14 0.65 10.58 0.5 9.59e-23 Hemoglobin concentration;Hematocrit; LUSC cis rs2455601 0.608 rs1368017 chr11:8867070 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -7.2 -0.37 4.05e-12 Schizophrenia; LUSC cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -9.37 -0.46 1.15e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8060686 0.545 rs12444188 chr16:68282077 G/A cg05110241 chr16:68378359 PRMT7 -0.69 -7.31 -0.37 2.01e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs11155671 0.530 rs7764376 chr6:150210344 A/G cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.67e-10 Testicular germ cell tumor; LUSC cis rs7577696 0.568 rs7574000 chr2:32342888 A/C cg02381751 chr2:32503542 YIPF4 -0.53 -7.08 -0.36 8.79e-12 Inflammatory biomarkers; LUSC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg26597838 chr10:835615 NA 0.96 13.11 0.58 5.87e-32 Eosinophil percentage of granulocytes; LUSC cis rs7818345 0.845 rs17407039 chr8:19268056 G/A cg11303988 chr8:19266685 CSGALNACT1 0.32 6.06 0.31 3.6e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs1371867 0.555 rs2861348 chr8:101285074 A/G cg06002616 chr8:101225028 SPAG1 -0.41 -6.85 -0.35 3.54e-11 Atrioventricular conduction; LUSC trans rs3942852 0.910 rs10742831 chr11:48119691 G/A cg03929089 chr4:120376271 NA -0.55 -6.33 -0.33 8.09e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg10523679 chr1:76189770 ACADM 0.84 12.83 0.57 6.74e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -8.02 -0.4 1.84e-14 Schizophrenia; LUSC cis rs2806561 0.704 rs856510 chr1:23524407 A/C cg12483005 chr1:23474871 LUZP1 0.44 6.86 0.35 3.39e-11 Height; LUSC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg16797656 chr11:68205561 LRP5 0.4 7.19 0.37 4.25e-12 Total body bone mineral density; LUSC cis rs1403694 0.515 rs1648722 chr3:186448989 C/T cg12454167 chr3:186435060 KNG1 0.28 7.6 0.38 2.98e-13 Blood protein levels; LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg27535305 chr1:53392650 SCP2 0.39 7.31 0.37 1.96e-12 Monocyte count; LUSC cis rs11158026 0.526 rs3825610 chr14:55347916 T/A cg04306507 chr14:55594613 LGALS3 0.4 6.46 0.33 3.78e-10 Parkinson's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08701034 chr19:36001408 DMKN 0.43 6.51 0.34 2.82e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.18 0.64 6.12e-40 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs459571 1.000 rs456207 chr9:136911140 G/A cg01294253 chr9:136912663 BRD3 0.36 6.35 0.33 6.86e-10 Platelet distribution width; LUSC cis rs4704187 0.687 rs4704179 chr5:74457273 C/T cg03227963 chr5:74354835 NA 0.31 6.8 0.35 4.74e-11 Response to amphetamines; LUSC cis rs116095464 0.558 rs9312956 chr5:201812 T/C cg22857025 chr5:266934 NA -1.19 -14.03 -0.61 1.79e-35 Breast cancer; LUSC cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg24642439 chr20:33292090 TP53INP2 0.41 5.88 0.31 9.72e-9 Height; LUSC cis rs11098499 0.909 rs11098530 chr4:120413154 C/T cg24375607 chr4:120327624 NA 0.79 12.05 0.55 5.19e-28 Corneal astigmatism; LUSC trans rs2235573 0.551 rs139898 chr22:38399979 A/G cg19894588 chr14:64061835 NA 0.47 6.72 0.35 7.86e-11 Glioblastoma;Glioma; LUSC cis rs9467773 0.620 rs2504566 chr6:26660488 G/C cg09904177 chr6:26538194 HMGN4 0.66 11.7 0.54 1.01e-26 Intelligence (multi-trait analysis); LUSC cis rs72772090 0.539 rs72773922 chr5:96116660 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.73 -0.35 7.35e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg13319975 chr6:146136371 FBXO30 -0.46 -7.12 -0.36 6.54e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs4295623 0.553 rs34962960 chr8:11594597 G/A cg15556689 chr8:8085844 FLJ10661 -0.54 -8.17 -0.41 6.35e-15 Morning vs. evening chronotype; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.71 0.39 1.43e-13 Prudent dietary pattern; LUSC cis rs2439831 0.850 rs7181039 chr15:44179112 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.49 0.42 7.05e-16 Lung cancer in ever smokers; LUSC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.48 0.33 3.32e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs10887741 0.546 rs4316430 chr10:89443649 G/A cg13926569 chr10:89418898 PAPSS2 0.31 6.72 0.35 7.88e-11 Exercise (leisure time); LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs1045714 0.895 rs73035504 chr7:2642878 G/A cg24848437 chr7:2645542 IQCE 0.63 6.97 0.36 1.72e-11 Urate levels in lean individuals; LUSC cis rs11971779 0.680 rs4398844 chr7:139043139 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.11 0.36 6.95e-12 Diisocyanate-induced asthma; LUSC cis rs6060717 0.610 rs6060755 chr20:34606915 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.22 -0.32 1.5e-9 Hip circumference adjusted for BMI; LUSC cis rs4474465 1.000 rs11237509 chr11:78173439 C/A cg27205649 chr11:78285834 NARS2 -0.49 -5.79 -0.3 1.61e-8 Alzheimer's disease (survival time); LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg15242686 chr22:24348715 GSTTP1 0.42 6.23 0.32 1.44e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg24920358 chr1:40204285 PPIE 0.6 10.77 0.51 2.03e-23 Blood protein levels; LUSC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg04733989 chr22:42467013 NAGA 0.54 8.35 0.42 1.88e-15 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02294249 chr13:34392492 RFC3 0.38 6.19 0.32 1.79e-9 Triglycerides; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18652121 chr3:179322868 MRPL47;NDUFB5 0.42 6.46 0.33 3.59e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs12541635 0.801 rs1429675 chr8:107101623 A/G cg10147462 chr8:107024639 NA -0.44 -7.77 -0.39 9.9e-14 Age of smoking initiation; LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg04166393 chr7:2884313 GNA12 0.45 5.98 0.31 5.7e-9 Height; LUSC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg00484396 chr16:3507460 NAT15 -0.45 -7.52 -0.38 5.25e-13 Body mass index (adult); LUSC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg02018176 chr4:1364513 KIAA1530 0.52 8.83 0.44 5.92e-17 Obesity-related traits; LUSC cis rs950169 0.800 rs4099846 chr15:84956894 C/G cg12863693 chr15:85201151 NMB 0.36 7.06 0.36 9.44e-12 Schizophrenia; LUSC cis rs12137294 0.866 rs1078362 chr1:205209530 A/G cg21643547 chr1:205240462 TMCC2 -0.35 -6.43 -0.33 4.48e-10 Red cell distribution width; LUSC cis rs7100689 0.784 rs4934083 chr10:82116501 G/C cg00277334 chr10:82204260 NA -0.49 -6.67 -0.34 1.09e-10 Post bronchodilator FEV1; LUSC cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg23649088 chr2:200775458 C2orf69 -0.53 -7.09 -0.36 8.14e-12 Schizophrenia; LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13012494 chr21:47604986 C21orf56 -0.47 -7.12 -0.36 6.78e-12 Testicular germ cell tumor; LUSC trans rs953492 0.731 rs10803133 chr1:243454014 A/G cg25284624 chr1:224180302 NA 0.4 6.12 0.32 2.56e-9 Diastolic blood pressure; LUSC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg22823121 chr1:150693482 HORMAD1 0.55 7.85 0.39 5.76e-14 Melanoma; LUSC cis rs117623576 0.941 rs7924082 chr10:32429126 A/G cg03047570 chr10:32398778 NA 0.54 5.97 0.31 6.05e-9 Anti-saccade response; LUSC cis rs10754283 0.967 rs6663363 chr1:90116854 A/G cg21401794 chr1:90099060 LRRC8C 0.62 9.05 0.44 1.18e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg13531842 chr10:38383804 ZNF37A -0.47 -7.29 -0.37 2.23e-12 Extrinsic epigenetic age acceleration; LUSC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.72 12.23 0.56 1.08e-28 Personality dimensions; LUSC cis rs870825 0.616 rs28660669 chr4:185623312 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg06641503 chr3:48959341 ARIH2 -0.39 -5.88 -0.31 9.73e-9 Parkinson's disease; LUSC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg15105969 chr2:36825350 FEZ2 0.47 6.32 0.33 8.46e-10 Height; LUSC trans rs2243480 1.000 rs1873494 chr7:65649899 T/C cg10756647 chr7:56101905 PSPH -0.84 -8.42 -0.42 1.14e-15 Diabetic kidney disease; LUSC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg00745463 chr17:30367425 LRRC37B -0.69 -8.37 -0.42 1.64e-15 Hip circumference adjusted for BMI; LUSC cis rs7119 0.717 rs12898281 chr15:77786903 C/T cg05673287 chr15:77411982 SGK269 0.43 6.94 0.36 2.02e-11 Type 2 diabetes; LUSC trans rs459571 0.629 rs441233 chr9:136876021 A/G cg10765909 chr12:53715428 AAAS 0.41 6.29 0.33 9.79e-10 Platelet distribution width; LUSC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg04287289 chr16:89883240 FANCA 0.78 13.64 0.6 5.58e-34 Vitiligo; LUSC cis rs6489882 0.902 rs4767040 chr12:113374017 C/G cg20102336 chr12:113376681 OAS3 -0.41 -5.94 -0.31 7.09e-9 Chronic lymphocytic leukemia; LUSC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg23172400 chr8:95962367 TP53INP1 -0.3 -5.79 -0.3 1.6e-8 Type 2 diabetes; LUSC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.72 6.98 0.36 1.62e-11 Cerebrospinal P-tau181p levels; LUSC cis rs2835872 0.758 rs1709821 chr21:39035622 T/C cg20424643 chr21:39039972 KCNJ6 -0.44 -7.48 -0.38 6.79e-13 Electroencephalographic traits in alcoholism; LUSC trans rs6598955 0.671 rs12139514 chr1:26575939 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg13798780 chr7:105162888 PUS7 0.56 6.22 0.32 1.45e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7903847 0.642 rs11189175 chr10:99139609 T/C cg20016023 chr10:99160130 RRP12 -0.33 -8.17 -0.41 6.41e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg00750074 chr16:89608354 SPG7 -0.46 -7.79 -0.39 8.64e-14 Multiple myeloma (IgH translocation); LUSC cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.39 -0.33 5.43e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.535 rs4841005 chr8:8501230 A/G cg15556689 chr8:8085844 FLJ10661 -0.53 -7.97 -0.4 2.59e-14 Mood instability; LUSC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg25767906 chr1:53392781 SCP2 0.39 6.78 0.35 5.63e-11 Monocyte count; LUSC cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.17e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs7246967 0.673 rs3951783 chr19:22839264 T/A cg23217946 chr19:22817039 ZNF492 0.49 6.8 0.35 4.87e-11 Bronchopulmonary dysplasia; LUSC cis rs977987 0.806 rs17696696 chr16:75393352 G/T cg04384234 chr16:75411784 CFDP1 0.41 6.94 0.35 2.06e-11 Dupuytren's disease; LUSC trans rs61931739 0.500 rs11053194 chr12:34440841 A/G cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.32e-18 Morning vs. evening chronotype; LUSC cis rs9902453 0.780 rs57037139 chr17:28173283 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.69 0.47 9.71e-20 Coffee consumption (cups per day); LUSC cis rs3768617 0.510 rs2224933 chr1:183095765 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs72960926 0.744 rs2352083 chr6:75023176 A/G cg03266952 chr6:74778945 NA -0.82 -7.01 -0.36 1.29e-11 Metabolite levels (MHPG); LUSC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.770 rs28683528 chr12:123845351 C/T cg13010344 chr12:123464640 ARL6IP4 0.49 6.44 0.33 4.06e-10 Neutrophil percentage of white cells; LUSC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg02807482 chr3:125708958 NA 0.47 5.88 0.31 9.8e-9 Blood pressure (smoking interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14546714 chr17:73179300 SUMO2 0.45 6.46 0.33 3.68e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg15423357 chr2:25149977 NA 0.4 7.84 0.39 6.29e-14 Body mass index in non-asthmatics; LUSC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.5 8.35 0.42 1.9e-15 Intelligence (multi-trait analysis); LUSC cis rs1059312 0.522 rs3825181 chr12:129279264 G/A cg09035930 chr12:129282057 SLC15A4 -0.6 -10.22 -0.49 1.69e-21 Systemic lupus erythematosus; LUSC cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 5.97 0.31 6.21e-9 Rheumatoid arthritis; LUSC cis rs7605827 0.930 rs6716384 chr2:15608210 A/G cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.69 0.39 1.63e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg21385522 chr1:16154831 NA 0.7 10.64 0.5 6.02e-23 Dilated cardiomyopathy; LUSC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg25204440 chr1:209979598 IRF6 0.5 5.72 0.3 2.36e-8 Cleft lip with or without cleft palate; LUSC trans rs6951245 0.935 rs113365567 chr7:1108785 T/C cg13565492 chr6:43139072 SRF -0.61 -6.39 -0.33 5.65e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg08999081 chr20:33150536 PIGU 0.44 8.2 0.41 5.25e-15 Coronary artery disease; LUSC cis rs9359856 0.529 rs72915915 chr6:90430593 T/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.89 -0.44 4e-17 Bipolar disorder; LUSC cis rs6558174 0.965 rs2404655 chr8:22490209 T/C cg03733263 chr8:22462867 KIAA1967 0.47 6.41 0.33 4.84e-10 Breast cancer; LUSC cis rs6977660 0.507 rs72591448 chr7:19775298 C/T cg07541023 chr7:19748670 TWISTNB 0.78 7.81 0.39 7.24e-14 Thyroid stimulating hormone; LUSC cis rs10504229 0.679 rs16921677 chr8:58052431 T/C cg08219700 chr8:58056026 NA 0.45 5.81 0.3 1.49e-8 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg24675056 chr1:15929824 NA 0.49 8.47 0.42 7.99e-16 Systolic blood pressure; LUSC cis rs62458065 0.640 rs10274556 chr7:32513947 A/G cg20159608 chr7:32802032 NA -0.74 -9.28 -0.45 2.15e-18 Metabolite levels (HVA/MHPG ratio); LUSC trans rs62238980 0.614 rs4820061 chr22:32378359 G/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs12681287 0.604 rs34227066 chr8:87449366 C/T cg27223183 chr8:87520930 FAM82B -0.54 -7.47 -0.38 6.9e-13 Caudate activity during reward; LUSC cis rs2180341 0.566 rs982306 chr6:127777039 T/C cg24812749 chr6:127587940 RNF146 0.55 7.53 0.38 4.75e-13 Breast cancer; LUSC cis rs9399135 1.000 rs4475342 chr6:135283348 T/C cg22676075 chr6:135203613 NA 0.5 7.71 0.39 1.46e-13 Red blood cell count; LUSC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2835872 0.733 rs1787400 chr21:39038217 G/C cg20424643 chr21:39039972 KCNJ6 -0.45 -7.33 -0.37 1.7e-12 Electroencephalographic traits in alcoholism; LUSC cis rs422249 0.512 rs1535 chr11:61597972 A/G cg19610905 chr11:61596333 FADS2 -0.54 -8.32 -0.41 2.33e-15 Trans fatty acid levels; LUSC cis rs4973397 0.509 rs10191571 chr2:232279975 C/A cg09339159 chr2:232260559 B3GNT7 0.48 7.02 0.36 1.23e-11 Anti-saccade response; LUSC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg17211192 chr8:82754475 SNX16 -0.58 -8.28 -0.41 2.93e-15 Diastolic blood pressure; LUSC cis rs7570971 0.617 rs1869829 chr2:135877562 C/T cg07169764 chr2:136633963 MCM6 -0.52 -6.99 -0.36 1.5e-11 Blood metabolite levels;Body mass index;Cholesterol, total; LUSC cis rs6424115 0.790 rs72874118 chr1:24177800 A/G cg10978503 chr1:24200527 CNR2 -0.54 -12.67 -0.57 2.67e-30 Immature fraction of reticulocytes; LUSC cis rs7267979 0.789 rs1983974 chr20:25530619 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -16.88 -0.68 1.13e-46 Liver enzyme levels (alkaline phosphatase); LUSC cis rs500891 0.953 rs1171101 chr6:84196539 A/C cg08257003 chr6:84140564 ME1 -0.33 -6.76 -0.35 6.13e-11 Platelet-derived growth factor BB levels; LUSC cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg00012203 chr2:219082015 ARPC2 -0.7 -11.59 -0.54 2.53e-26 Colorectal cancer; LUSC cis rs11122272 0.735 rs2790883 chr1:231532726 A/G cg06096015 chr1:231504339 EGLN1 0.58 10.29 0.49 9.77e-22 Hemoglobin concentration; LUSC cis rs1559088 0.739 rs9304845 chr19:33592794 A/G cg03563238 chr19:33554763 RHPN2 -0.41 -6.47 -0.33 3.5e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7824557 0.767 rs11775635 chr8:11164865 G/A cg27411982 chr8:10470053 RP1L1 0.38 5.99 0.31 5.32e-9 Retinal vascular caliber; LUSC cis rs7582180 0.652 rs11694700 chr2:100936637 C/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.49 -0.42 6.69e-16 Intelligence (multi-trait analysis); LUSC cis rs7809950 0.678 rs3801966 chr7:106824580 G/A cg23024343 chr7:107201750 COG5 -0.62 -8.67 -0.43 1.92e-16 Coronary artery disease; LUSC cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.74 -0.3 2.14e-8 Depression; LUSC cis rs977987 0.806 rs11864102 chr16:75442360 C/T cg03315344 chr16:75512273 CHST6 0.48 9.05 0.44 1.21e-17 Dupuytren's disease; LUSC cis rs453301 0.682 rs2929308 chr8:9084121 T/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.26 -0.32 1.18e-9 Joint mobility (Beighton score); LUSC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08109568 chr15:31115862 NA -0.59 -8.22 -0.41 4.55e-15 Huntington's disease progression; LUSC cis rs17826219 0.636 rs12946563 chr17:29103166 C/G cg13385521 chr17:29058706 SUZ12P 0.68 6.74 0.35 7.03e-11 Body mass index; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg07395648 chr5:131743802 NA 0.39 5.84 0.3 1.24e-8 Breast cancer; LUSC trans rs11088226 0.681 rs1015048 chr21:33949306 T/C cg09050820 chr6:167586206 TCP10L2 0.75 9.94 0.48 1.49e-20 Gastritis; LUSC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.1e-30 Aortic root size; LUSC cis rs807669 0.586 rs5746671 chr22:19160899 A/G cg02655711 chr22:19163373 SLC25A1 0.59 11.07 0.52 1.82e-24 Metabolite levels; LUSC cis rs9837602 1.000 rs793472 chr3:99546110 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -5.79 -0.3 1.61e-8 Breast cancer; LUSC trans rs629535 0.547 rs72654095 chr8:70120770 A/G cg21567404 chr3:27674614 NA -0.92 -13.35 -0.59 6.83e-33 Dupuytren's disease; LUSC trans rs877282 0.583 rs10904566 chr10:821662 C/G cg22713356 chr15:30763199 NA 0.78 10.05 0.48 6.17e-21 Uric acid levels; LUSC cis rs9487051 0.803 rs11153161 chr6:109541774 A/G cg00509249 chr6:109615579 CCDC162 -0.34 -5.81 -0.3 1.42e-8 Reticulocyte fraction of red cells; LUSC cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg17845761 chr1:175162550 KIAA0040 0.3 5.73 0.3 2.24e-8 Alcohol dependence; LUSC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg00784671 chr22:46762841 CELSR1 -0.49 -6.67 -0.34 1.04e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs11864453 0.578 rs2072141 chr16:72133211 G/A cg16558253 chr16:72132732 DHX38 -0.38 -6.07 -0.32 3.45e-9 Fibrinogen levels; LUSC cis rs1322512 1.000 rs2800625 chr6:153006016 A/G cg27316956 chr6:152958899 SYNE1 0.34 5.98 0.31 5.72e-9 Tonometry; LUSC cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg26898376 chr11:64110657 CCDC88B 0.33 6.16 0.32 2.06e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs6912958 0.500 rs4706287 chr6:87806496 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.09 -0.45 8.85e-18 Monocyte percentage of white cells; LUSC cis rs6541297 0.938 rs7551742 chr1:230290118 A/G cg05784532 chr1:230284198 GALNT2 0.55 8.07 0.4 1.29e-14 Coronary artery disease; LUSC trans rs1814175 0.715 rs7479622 chr11:49673340 T/G cg15704280 chr7:45808275 SEPT13 -1.08 -21.87 -0.77 1.98e-66 Height; LUSC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg15147215 chr3:52552868 STAB1 -0.32 -6.21 -0.32 1.54e-9 Bipolar disorder; LUSC cis rs2274273 0.805 rs28612464 chr14:55816411 T/C cg04306507 chr14:55594613 LGALS3 0.53 11.62 0.54 1.95e-26 Protein biomarker; LUSC cis rs7202877 0.610 rs11646418 chr16:75367585 G/C cg04384234 chr16:75411784 CFDP1 -0.63 -8.46 -0.42 8.43e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs2227564 0.649 rs2243610 chr10:75601653 A/T cg23231163 chr10:75533350 FUT11 -0.43 -6.09 -0.32 3.08e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.38 6.01 0.31 4.72e-9 Electroencephalogram traits; LUSC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg13114125 chr14:105738426 BRF1 -0.86 -14.6 -0.62 1.1e-37 Mean platelet volume;Platelet distribution width; LUSC trans rs7829975 0.593 rs2921077 chr8:8304502 C/T cg21775007 chr8:11205619 TDH 0.42 6.31 0.33 8.74e-10 Mood instability; LUSC cis rs4642101 0.512 rs12629892 chr3:12818920 A/G cg05775895 chr3:12838266 CAND2 0.51 8.8 0.43 7.4e-17 QRS complex (12-leadsum); LUSC cis rs10191773 0.589 rs72831638 chr2:112949212 C/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.74 7.74 0.39 1.17e-13 Yeast infection; LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg08470875 chr2:26401718 FAM59B -0.69 -9.37 -0.46 1.16e-18 Gut microbiome composition (summer); LUSC cis rs7589728 1.000 rs11893832 chr2:88507537 G/C cg04511125 chr2:88470314 THNSL2 0.7 6.6 0.34 1.65e-10 Plasma clusterin levels; LUSC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC cis rs1788820 0.917 rs1624695 chr18:21142992 A/T cg14672496 chr18:21087552 C18orf8 0.42 6.89 0.35 2.86e-11 Body mass index; LUSC cis rs9355610 0.609 rs3756838 chr6:167371251 G/A cg23791538 chr6:167370224 RNASET2 0.41 5.9 0.31 8.99e-9 Graves' disease; LUSC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg16240275 chr20:61666158 NCRNA00029 0.42 9.4 0.46 9.21e-19 Prostate cancer (SNP x SNP interaction); LUSC cis rs2742234 0.955 rs2075913 chr10:43622368 T/A cg15436174 chr10:43711423 RASGEF1A -0.36 -6.68 -0.34 9.8e-11 Hirschsprung disease; LUSC cis rs12760731 0.720 rs12691481 chr1:178392653 T/C cg00404053 chr1:178313656 RASAL2 0.54 6.23 0.32 1.38e-9 Obesity-related traits; LUSC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg15352829 chr14:105391018 PLD4 -0.43 -9.01 -0.44 1.62e-17 Rheumatoid arthritis; LUSC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg09021430 chr5:549028 NA -0.56 -7.48 -0.38 6.59e-13 Obesity-related traits; LUSC cis rs1185460 0.967 rs1177563 chr11:118949083 C/T cg01677386 chr11:118938358 VPS11 -0.49 -6.96 -0.36 1.8e-11 Coronary artery disease; LUSC cis rs9952991 0.941 rs60735058 chr18:12795470 T/A cg23598886 chr18:12777645 NA -0.58 -5.75 -0.3 2.01e-8 Inflammatory skin disease; LUSC cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg10518543 chr12:38710700 ALG10B -0.42 -5.89 -0.31 9.47e-9 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs2219968 0.728 rs1988920 chr8:78841080 G/T cg00738934 chr8:78996279 NA -0.36 -6.15 -0.32 2.16e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6977660 0.652 rs10267417 chr7:19843797 C/T cg07541023 chr7:19748670 TWISTNB 0.61 6.02 0.31 4.56e-9 Thyroid stimulating hormone; LUSC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg27398817 chr8:82754497 SNX16 0.47 6.38 0.33 5.89e-10 Diastolic blood pressure; LUSC cis rs2625529 0.730 rs2929527 chr15:72282270 T/G cg16672083 chr15:72433130 SENP8 0.49 8.05 0.4 1.43e-14 Red blood cell count; LUSC trans rs1814175 0.817 rs11040474 chr11:49708441 G/A cg03929089 chr4:120376271 NA -1.03 -19.85 -0.74 1.79e-58 Height; LUSC cis rs8114671 0.933 rs6142327 chr20:33793147 T/A cg24642439 chr20:33292090 TP53INP2 -0.41 -6.02 -0.31 4.51e-9 Height; LUSC cis rs7605827 0.930 rs11680044 chr2:15607103 T/G cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.67 0.6 4.11e-34 Platelet count; LUSC trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg16339924 chr4:17578868 LAP3 0.48 7.11 0.36 7.16e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1595825 0.891 rs73056877 chr2:198816724 A/C cg10547527 chr2:198650123 BOLL -0.5 -5.87 -0.31 1.04e-8 Ulcerative colitis; LUSC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg07395648 chr5:131743802 NA 0.37 5.83 0.3 1.29e-8 Asthma (sex interaction); LUSC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg08219700 chr8:58056026 NA 0.5 5.93 0.31 7.63e-9 Developmental language disorder (linguistic errors); LUSC cis rs12410462 0.581 rs6675521 chr1:227544702 C/T cg10327440 chr1:227177885 CDC42BPA -0.66 -6.47 -0.33 3.44e-10 Major depressive disorder; LUSC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg04850211 chr1:228464232 OBSCN -0.33 -6.15 -0.32 2.27e-9 Diastolic blood pressure; LUSC cis rs3768617 0.510 rs3768616 chr1:183103551 T/C ch.1.3577855R chr1:183094577 LAMC1 0.73 11.21 0.52 5.74e-25 Fuchs's corneal dystrophy; LUSC cis rs6688613 0.685 rs10918600 chr1:166919342 C/T cg07049167 chr1:166818506 POGK -0.43 -6.3 -0.33 9.33e-10 Refractive astigmatism; LUSC cis rs4478858 0.684 rs16865957 chr1:31753353 G/A cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs10751667 0.666 rs7395488 chr11:954111 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.07e-10 Alzheimer's disease (late onset); LUSC trans rs724744 0.742 rs1205931 chr6:22358551 T/A cg13807341 chr11:118445984 ARCN1 -0.35 -5.95 -0.31 6.64e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg05234568 chr11:5960015 NA -0.55 -8.66 -0.43 2.1e-16 DNA methylation (variation); LUSC cis rs7189233 0.531 rs4783813 chr16:53518370 C/G cg09728985 chr16:53543985 NA -0.3 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); LUSC cis rs709400 0.567 rs11624343 chr14:103859156 T/A cg10523860 chr14:103875565 MARK3 -0.4 -6.32 -0.33 8.26e-10 Body mass index; LUSC cis rs1784581 0.651 rs1784589 chr6:162389571 A/G cg17173639 chr6:162384350 PARK2 -0.68 -12.19 -0.55 1.59e-28 Itch intensity from mosquito bite; LUSC cis rs9388451 0.839 rs11154331 chr6:126111429 A/T cg05901451 chr6:126070800 HEY2 -0.93 -18.14 -0.7 1.14e-51 Brugada syndrome; LUSC trans rs1005277 0.579 rs2472181 chr10:38386764 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.5 -0.46 4.29e-19 Extrinsic epigenetic age acceleration; LUSC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg02167203 chr6:41068553 NFYA;LOC221442 0.39 5.85 0.3 1.17e-8 Alzheimer's disease (late onset); LUSC cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg04362960 chr10:104952993 NT5C2 0.67 9.13 0.45 6.82e-18 Arsenic metabolism; LUSC cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg15839431 chr19:19639596 YJEFN3 -0.66 -7.29 -0.37 2.33e-12 Bipolar disorder; LUSC cis rs67478160 0.643 rs6576005 chr14:104292369 C/T cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.47 -0.46 5.1e-19 Schizophrenia; LUSC trans rs11088226 0.538 rs4816436 chr21:33880251 A/G cg09050820 chr6:167586206 TCP10L2 0.47 7.1 0.36 7.49e-12 Gastritis; LUSC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.37 0.53 1.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9325144 0.600 rs12227663 chr12:38734922 C/T cg26384229 chr12:38710491 ALG10B -0.6 -9.29 -0.45 2.04e-18 Morning vs. evening chronotype; LUSC cis rs1322512 0.958 rs12195158 chr6:153006544 T/C cg27316956 chr6:152958899 SYNE1 0.35 6.09 0.32 3.07e-9 Tonometry; LUSC cis rs2274273 0.934 rs2341621 chr14:55726425 C/T cg04306507 chr14:55594613 LGALS3 0.56 13.15 0.58 4.03e-32 Protein biomarker; LUSC cis rs9486719 0.843 rs2499796 chr6:96848364 A/G cg06623918 chr6:96969491 KIAA0776 0.74 8.85 0.44 5.39e-17 Migraine;Coronary artery disease; LUSC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.4 0.62 6.35e-37 Platelet count; LUSC cis rs950776 0.518 rs12916999 chr15:78826912 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg01884057 chr2:25150051 NA 0.48 11.37 0.53 1.53e-25 Body mass index; LUSC cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg17063962 chr7:91808500 NA 0.59 9.36 0.46 1.22e-18 Breast cancer; LUSC cis rs600231 0.683 rs588298 chr11:65253574 A/G cg21890820 chr11:65308645 LTBP3 0.48 7.17 0.37 4.81e-12 Bone mineral density; LUSC cis rs12137294 0.866 rs1172153 chr1:205220661 T/C cg21643547 chr1:205240462 TMCC2 -0.35 -6.4 -0.33 5.2e-10 Red cell distribution width; LUSC cis rs12421382 0.507 rs2186673 chr11:109285519 G/A cg27471124 chr11:109292789 C11orf87 0.52 8.58 0.42 3.74e-16 Schizophrenia; LUSC trans rs6951245 0.938 rs78351779 chr7:1097023 G/C cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6546550 0.803 rs10165883 chr2:70117015 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.45 -0.38 7.85e-13 Prevalent atrial fibrillation; LUSC cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg09469691 chr10:81107165 PPIF -0.66 -10.39 -0.49 4.2e-22 Height; LUSC trans rs35110281 0.782 rs1454650 chr21:45012353 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.7 0.51 3.71e-23 Mean corpuscular volume; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg01516881 chr6:292596 DUSP22 -0.52 -7.58 -0.38 3.53e-13 Menopause (age at onset); LUSC cis rs11264799 0.539 rs2777968 chr1:157549325 T/G cg18268488 chr1:157545234 FCRL4 0.39 7.61 0.38 2.88e-13 IgA nephropathy; LUSC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg09165964 chr15:75287851 SCAMP5 0.5 7.38 0.37 1.26e-12 Breast cancer; LUSC cis rs2070997 0.667 rs13295907 chr9:133718242 G/T cg11464064 chr9:133710261 ABL1 0.48 5.65 0.3 3.47e-8 Response to amphetamines; LUSC cis rs11030122 0.702 rs10835402 chr11:3990914 T/C cg08557956 chr11:4115526 RRM1 -0.47 -5.95 -0.31 6.69e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg17264618 chr3:40429014 ENTPD3 0.32 6.7 0.34 8.83e-11 Renal cell carcinoma; LUSC cis rs2050392 0.517 rs2489847 chr10:30743673 G/A cg25182066 chr10:30743637 MAP3K8 -0.48 -6.74 -0.35 6.94e-11 Inflammatory bowel disease; LUSC cis rs6500395 0.928 rs12934788 chr16:48706343 C/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.74 -0.35 6.96e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.58e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs2859741 0.967 rs535876 chr1:37484052 C/G cg09363841 chr1:37513479 NA -0.39 -7.96 -0.4 2.79e-14 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs7707921 0.767 rs6894520 chr5:81594748 C/T cg21483461 chr5:81570383 RPS23 -0.38 -5.72 -0.3 2.36e-8 Breast cancer; LUSC cis rs9467773 0.572 rs62394558 chr6:26604650 G/A cg05738196 chr6:26577821 NA 0.77 13.72 0.6 2.75e-34 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg02187348 chr16:89574699 SPG7 0.62 10.37 0.49 4.87e-22 Multiple myeloma (IgH translocation); LUSC cis rs4474465 1.000 rs11237500 chr11:78163636 G/A cg27205649 chr11:78285834 NARS2 -0.52 -6.16 -0.32 2.11e-9 Alzheimer's disease (survival time); LUSC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg17211192 chr8:82754475 SNX16 -0.6 -8.51 -0.42 5.97e-16 Diastolic blood pressure; LUSC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.15 -0.36 5.49e-12 Major depressive disorder; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg11965913 chr1:205819406 PM20D1 0.93 19.08 0.72 2.06e-55 Menarche (age at onset); LUSC cis rs1355223 1.000 rs1355223 chr11:34764479 A/G cg11058730 chr11:34937778 PDHX;APIP -0.4 -5.71 -0.3 2.54e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg24130564 chr14:104152367 KLC1 -0.48 -7.02 -0.36 1.24e-11 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg21535247 chr6:8435926 SLC35B3 -0.59 -9.13 -0.45 6.77e-18 Motion sickness; LUSC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg15448220 chr1:150897856 SETDB1 0.43 6.2 0.32 1.63e-9 Melanoma; LUSC cis rs453301 0.631 rs17700611 chr8:8793654 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.12 -0.32 2.64e-9 Joint mobility (Beighton score); LUSC cis rs75804782 0.520 rs72987319 chr2:239351143 C/T cg18131467 chr2:239335373 ASB1 -0.75 -6.67 -0.34 1.04e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs2708377 0.858 rs115781584 chr12:11304560 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.82 7.95 0.4 2.96e-14 Bitter taste perception; LUSC cis rs7312774 0.609 rs2374656 chr12:107380411 A/C cg16260113 chr12:107380972 MTERFD3 0.84 6.17 0.32 1.99e-9 Severe influenza A (H1N1) infection; LUSC cis rs796364 0.625 rs13035260 chr2:201132377 A/G cg23649088 chr2:200775458 C2orf69 -0.57 -7.43 -0.38 9.27e-13 Schizophrenia; LUSC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.38 7.51 0.38 5.28e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg18876405 chr7:65276391 NA -0.65 -11.77 -0.54 5.47e-27 Aortic root size; LUSC cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg17063962 chr7:91808500 NA 0.6 9.45 0.46 5.98e-19 Breast cancer; LUSC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11890956 chr21:40555474 PSMG1 1.04 21.21 0.76 7.95e-64 Cognitive function; LUSC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs2637266 0.783 rs846583 chr10:78495658 T/A cg18941641 chr10:78392320 NA 0.4 7.25 0.37 2.91e-12 Pulmonary function; LUSC cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14240646 chr10:27532245 ACBD5 0.88 8.42 0.42 1.16e-15 Breast cancer; LUSC cis rs2717559 0.542 rs11774823 chr8:143887568 G/T cg07661805 chr8:143867942 LY6D -0.26 -6.02 -0.31 4.54e-9 Urinary tract infection frequency; LUSC cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg17063962 chr7:91808500 NA -0.59 -9.34 -0.46 1.4e-18 Breast cancer; LUSC cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg16339924 chr4:17578868 LAP3 0.55 8.47 0.42 7.79e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.754 rs28663627 chr11:50048829 C/T cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs6977660 1.000 rs6959889 chr7:19822024 A/C cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC trans rs10506458 0.834 rs12426893 chr12:63388120 G/T cg22491629 chr6:157744540 C6orf35 -0.88 -10.67 -0.5 4.68e-23 Hemostatic factors and hematological phenotypes; LUSC trans rs11165623 0.564 rs9887897 chr1:96996671 T/C cg10631902 chr5:14652156 NA -0.41 -6.08 -0.32 3.24e-9 Hip circumference;Waist circumference; LUSC cis rs853679 0.546 rs35819751 chr6:27810569 A/G cg26958806 chr6:27640298 NA 0.84 6.6 0.34 1.66e-10 Depression; LUSC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg09021430 chr5:549028 NA -0.55 -7.55 -0.38 4.23e-13 Obesity-related traits; LUSC cis rs1595825 0.891 rs74965164 chr2:198499162 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.67 -0.34 1.04e-10 Ulcerative colitis; LUSC cis rs2742234 0.868 rs2505512 chr10:43633596 G/A cg15436174 chr10:43711423 RASGEF1A -0.37 -6.51 -0.34 2.79e-10 Hirschsprung disease; LUSC cis rs738322 0.726 rs5750561 chr22:38595260 A/T cg25457927 chr22:38595422 NA 0.52 11.5 0.53 5.21e-26 Cutaneous nevi; LUSC cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -13.75 -0.6 2.07e-34 Extrinsic epigenetic age acceleration; LUSC cis rs727505 1.000 rs67585224 chr7:124537476 A/C cg23710748 chr7:124431027 NA -0.42 -7.54 -0.38 4.53e-13 Lewy body disease; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg03043160 chr13:76056444 TBC1D4 -0.51 -6.21 -0.32 1.55e-9 Neuroticism; LUSC cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg21016266 chr12:122356598 WDR66 -0.58 -8.66 -0.43 2.05e-16 Mean corpuscular volume; LUSC cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.04 0.4 1.54e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01555853 chr2:18059744 KCNS3 0.41 6.06 0.31 3.76e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11758351 1.000 rs75921373 chr6:26191843 C/T cg11342453 chr6:26196699 NA 0.54 5.71 0.3 2.52e-8 Gout;Renal underexcretion gout; LUSC trans rs7829975 0.714 rs6994038 chr8:8660538 C/A cg27411982 chr8:10470053 RP1L1 0.42 6.42 0.33 4.57e-10 Mood instability; LUSC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.59 -0.34 1.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg02569458 chr12:86230093 RASSF9 0.61 10.25 0.49 1.32e-21 Major depressive disorder; LUSC trans rs1941687 0.702 rs1493924 chr18:31314721 T/C cg27147174 chr7:100797783 AP1S1 -0.46 -6.69 -0.34 9.18e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs12266014 0.895 rs11014296 chr10:25202038 C/T cg16316141 chr10:25305874 ENKUR;THNSL1 0.39 5.66 0.3 3.18e-8 Monocyte count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;White blood cell count;Neutrophil count;Myeloid white cell count; LUSC cis rs8072100 0.902 rs12051716 chr17:45582395 G/A cg08085267 chr17:45401833 C17orf57 0.53 8.61 0.43 2.88e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4713118 0.699 rs200969 chr6:27859453 T/C cg12963246 chr6:28129442 ZNF389 0.45 6.19 0.32 1.79e-9 Parkinson's disease; LUSC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg04398451 chr17:18023971 MYO15A 0.44 6.96 0.36 1.79e-11 Total body bone mineral density; LUSC cis rs9486719 0.843 rs2205754 chr6:96843134 T/C cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs16917546 1.000 rs10995248 chr10:64396042 A/G cg03961010 chr10:64397487 ZNF365 0.41 6.65 0.34 1.2e-10 Basal cell carcinoma; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg09403165 chr15:90118814 C15orf42 0.51 6.34 0.33 7.66e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs3857536 0.740 rs9354392 chr6:66894555 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.36 -0.33 6.61e-10 Blood trace element (Cu levels); LUSC cis rs9393692 0.537 rs2393594 chr6:26316289 G/A cg00631329 chr6:26305371 NA -0.43 -6.09 -0.32 3.11e-9 Educational attainment; LUSC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.25 0.49 1.34e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg04756594 chr16:24857601 SLC5A11 0.42 5.84 0.3 1.24e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.64 0.39 2.35e-13 Bipolar disorder; LUSC cis rs6714710 0.580 rs57804205 chr2:98454472 G/A cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7312933 0.558 rs7305397 chr12:42850058 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.47 6.6 0.34 1.62e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg18876405 chr7:65276391 NA 0.67 11.87 0.54 2.37e-27 Aortic root size; LUSC cis rs8141797 0.642 rs1004058 chr22:24482500 A/C cg00411358 chr22:24577142 SUSD2 0.61 5.95 0.31 6.82e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs796364 0.806 rs79897806 chr2:201073968 G/A cg23649088 chr2:200775458 C2orf69 -0.57 -6.74 -0.35 7.11e-11 Schizophrenia; LUSC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg04013166 chr16:89971882 TCF25 0.54 5.92 0.31 7.93e-9 Skin colour saturation; LUSC trans rs9467711 0.790 rs35400317 chr6:26593275 C/T cg06606381 chr12:133084897 FBRSL1 -0.89 -7.54 -0.38 4.61e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg12463550 chr7:65579703 CRCP -0.63 -5.68 -0.3 2.92e-8 Diabetic kidney disease; LUSC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.61e-8 Diabetic kidney disease; LUSC trans rs2288327 0.591 rs2562845 chr2:179514433 T/C cg14011486 chr1:26737247 LIN28 0.51 6.43 0.33 4.3e-10 Atrial fibrillation; LUSC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg20607287 chr7:12443886 VWDE -0.58 -6.77 -0.35 5.96e-11 Coronary artery disease; LUSC cis rs7903847 0.596 rs7922512 chr10:99155685 C/A cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7100689 0.646 rs11202725 chr10:82136276 A/G cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC trans rs11098499 0.909 rs10020034 chr4:120294331 A/G cg25214090 chr10:38739885 LOC399744 0.55 7.9 0.4 4.05e-14 Corneal astigmatism; LUSC cis rs4074961 0.527 rs10908356 chr1:38038388 G/A cg02930200 chr1:38022384 DNALI1 0.29 5.9 0.31 8.81e-9 Axial length; LUSC cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.63 9.63 0.47 1.59e-19 Menarche (age at onset); LUSC cis rs11153306 0.515 rs3213575 chr6:111919271 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.35 -6.75 -0.35 6.65e-11 Tonsillectomy; LUSC cis rs7481584 0.581 rs399565 chr11:3061780 C/T cg25174290 chr11:3078921 CARS -0.41 -6.12 -0.32 2.68e-9 Calcium levels; LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg04267008 chr7:1944627 MAD1L1 -0.61 -9.22 -0.45 3.32e-18 Bipolar disorder and schizophrenia; LUSC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.5 7.43 0.38 8.96e-13 Menarche (age at onset); LUSC cis rs7267979 0.549 rs6138537 chr20:25184466 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.58 10.11 0.48 3.81e-21 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6952808 0.929 rs12532128 chr7:1925454 T/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.42 0.33 4.7e-10 Bipolar disorder and schizophrenia; LUSC cis rs28735056 0.933 rs499472 chr18:77589759 C/T cg20368463 chr18:77673604 PQLC1 -0.54 -7.75 -0.39 1.15e-13 Schizophrenia; LUSC trans rs11700980 0.551 rs2832014 chr21:30110966 T/A cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.41e-9 QRS complex (12-leadsum); LUSC cis rs5769765 0.773 rs138861 chr22:50202276 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.75 -9.81 -0.47 3.96e-20 Schizophrenia; LUSC cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg22117172 chr7:91764530 CYP51A1 0.33 5.85 0.3 1.18e-8 Breast cancer; LUSC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg01475377 chr6:109611718 NA 0.38 6.67 0.34 1.06e-10 Reticulocyte fraction of red cells; LUSC cis rs8071789 1.000 rs8071789 chr17:38006333 C/T cg20243544 chr17:37824526 PNMT 0.4 5.93 0.31 7.54e-9 Selective IgA deficiency; LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.64 -10.74 -0.51 2.71e-23 Prudent dietary pattern; LUSC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg04017836 chr7:65315216 NA -0.37 -5.95 -0.31 6.75e-9 Height; LUSC trans rs6502050 0.799 rs4789673 chr17:80123218 T/C cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg14895029 chr7:2775587 GNA12 -0.4 -5.95 -0.31 6.94e-9 Height; LUSC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg22029157 chr1:209979665 IRF6 0.78 9.85 0.47 2.93e-20 Cleft lip with or without cleft palate; LUSC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs250677 1.000 rs28173 chr5:148423573 C/T cg05026186 chr5:148520876 ABLIM3 -0.37 -6.01 -0.31 4.77e-9 Breast cancer; LUSC cis rs250677 0.522 rs4431331 chr5:148353574 A/C cg18129178 chr5:148520854 ABLIM3 -0.49 -6.95 -0.36 1.91e-11 Breast cancer; LUSC trans rs9329221 0.527 rs7833781 chr8:10333477 A/G cg15556689 chr8:8085844 FLJ10661 0.49 6.94 0.36 2.02e-11 Neuroticism; LUSC cis rs116988415 0.584 rs17180497 chr14:65269707 A/C cg25083366 chr14:65239357 SPTB -0.65 -6.96 -0.36 1.75e-11 Daytime sleep phenotypes; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg13560548 chr3:10150139 C3orf24 0.51 7.32 0.37 1.85e-12 Alzheimer's disease; LUSC cis rs9902453 0.765 rs2127001 chr17:28098219 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.71 -0.54 9.26e-27 Coffee consumption (cups per day); LUSC cis rs9650657 0.770 rs9969626 chr8:10670801 A/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.34 -0.33 7.25e-10 Neuroticism; LUSC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg12310025 chr6:25882481 NA -0.45 -7.83 -0.39 6.42e-14 Height; LUSC cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.39 -0.38 1.16e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.45 7.57 0.38 3.6e-13 Electroencephalogram traits; LUSC cis rs34779708 0.966 rs4934537 chr10:35441512 C/T cg04310649 chr10:35416472 CREM -0.42 -6.59 -0.34 1.71e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg01657329 chr11:68192670 LRP5 -0.43 -6.87 -0.35 3.14e-11 Total body bone mineral density; LUSC cis rs7769051 0.522 rs6928933 chr6:133116073 G/A cg07930552 chr6:133119739 C6orf192 0.95 8.49 0.42 7.03e-16 Type 2 diabetes nephropathy; LUSC cis rs912057 0.671 rs1294428 chr6:6744623 A/G cg06612196 chr6:6737390 NA 0.56 11.11 0.52 1.32e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs9814567 0.896 rs7653807 chr3:134345724 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -5.77 -0.3 1.84e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg05043794 chr9:111880884 C9orf5 -0.32 -6.75 -0.35 6.51e-11 Menarche (age at onset); LUSC cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.7 -0.39 1.6e-13 Personality dimensions; LUSC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg24675658 chr1:53192096 ZYG11B -0.53 -7.53 -0.38 4.89e-13 Monocyte count; LUSC cis rs8013055 0.898 rs8004007 chr14:105971435 G/C cg19700328 chr14:106028568 NA -0.41 -6.9 -0.35 2.58e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs2979489 0.945 rs12548554 chr8:30346544 G/A cg26383811 chr8:30366931 RBPMS -0.55 -8.63 -0.43 2.56e-16 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC trans rs2797160 1.000 rs4895798 chr6:126000162 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.59 -0.34 1.71e-10 Endometrial cancer; LUSC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.7 -0.34 8.72e-11 Tonsillectomy; LUSC trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg15704280 chr7:45808275 SEPT13 0.86 11.38 0.53 1.4e-25 Coronary artery disease; LUSC cis rs2933343 0.700 rs789240 chr3:128630635 T/C cg11901034 chr3:128598214 ACAD9 -0.42 -6.67 -0.34 1.09e-10 IgG glycosylation; LUSC trans rs2204008 0.743 rs2132212 chr12:38039405 G/A cg06521331 chr12:34319734 NA -0.4 -6.32 -0.33 8.55e-10 Bladder cancer; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg07157834 chr1:205819609 PM20D1 0.52 8.38 0.42 1.5e-15 Menarche (age at onset); LUSC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg20503657 chr10:835505 NA 1.22 16.34 0.67 1.68e-44 Eosinophil percentage of granulocytes; LUSC trans rs3733585 0.699 rs6815001 chr4:9958662 G/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg14403583 chr14:105418241 AHNAK2 -0.57 -9.68 -0.47 1.1e-19 Rheumatoid arthritis; LUSC cis rs6831352 0.765 rs35361391 chr4:100069281 A/T cg12011299 chr4:100065546 ADH4 -0.72 -10.42 -0.5 3.38e-22 Alcohol dependence; LUSC cis rs7000551 0.619 rs2443506 chr8:22373383 T/C cg12081754 chr8:22256438 SLC39A14 0.42 6.35 0.33 7.14e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs10905065 0.735 rs10795347 chr10:5742077 C/G cg25171089 chr10:5708825 ASB13 -0.4 -5.73 -0.3 2.25e-8 Menopause (age at onset); LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg21782813 chr7:2030301 MAD1L1 0.45 7.43 0.38 9.07e-13 Bipolar disorder and schizophrenia; LUSC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6456156 0.792 rs9366089 chr6:167512896 A/G cg07741184 chr6:167504864 NA 0.37 6.37 0.33 6.38e-10 Primary biliary cholangitis; LUSC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg08392591 chr16:89556376 ANKRD11 0.47 7.27 0.37 2.59e-12 Multiple myeloma (IgH translocation); LUSC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg08219700 chr8:58056026 NA 0.45 5.75 0.3 1.98e-8 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg06634786 chr22:41940651 POLR3H -0.53 -6.47 -0.33 3.45e-10 Vitiligo; LUSC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg06641503 chr3:48959341 ARIH2 -0.39 -5.88 -0.31 9.73e-9 Parkinson's disease; LUSC cis rs9362426 0.708 rs7744793 chr6:88102040 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.37 5.98 0.31 5.67e-9 Depressive episodes in bipolar disorder; LUSC trans rs637571 0.522 rs1151512 chr11:65757533 G/A cg17712092 chr4:129076599 LARP1B 0.72 10.85 0.51 1.08e-23 Eosinophil percentage of white cells; LUSC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg03676636 chr4:99064102 C4orf37 0.37 7.68 0.39 1.8e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.63 -0.43 2.45e-16 Lung cancer; LUSC cis rs72781680 0.752 rs72796114 chr2:23906133 C/G cg08917208 chr2:24149416 ATAD2B 0.98 9.69 0.47 9.64e-20 Lymphocyte counts; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg01495663 chr14:21945285 RAB2B;TOX4 0.46 6.66 0.34 1.1e-10 Mosquito bite size; LUSC trans rs1493916 1.000 rs12457802 chr18:31389865 A/G cg15819921 chr19:927150 ARID3A 0.44 6.53 0.34 2.48e-10 Life satisfaction; LUSC cis rs4891159 0.790 rs8085133 chr18:74144083 A/C cg24786174 chr18:74118243 ZNF516 -0.9 -18.48 -0.71 4.91e-53 Longevity; LUSC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg15017067 chr4:17643749 FAM184B 0.34 5.66 0.3 3.25e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9457247 0.967 rs382009 chr6:167403121 G/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg11247378 chr22:39784982 NA -0.63 -12.21 -0.56 1.34e-28 Intelligence (multi-trait analysis); LUSC trans rs6076960 0.684 rs6054055 chr20:6257517 C/G cg17788362 chr6:86352627 SYNCRIP 0.48 7.17 0.37 4.95e-12 Smooth-surface caries; LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg16145915 chr7:1198662 ZFAND2A -0.6 -10.73 -0.51 2.85e-23 Longevity;Endometriosis; LUSC cis rs12421382 0.659 rs12417251 chr11:109386273 G/T cg11473876 chr11:109292803 C11orf87 0.41 6.76 0.35 6.14e-11 Schizophrenia; LUSC cis rs17826219 0.500 rs9891256 chr17:29072692 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Body mass index; LUSC cis rs62400317 0.826 rs12194628 chr6:45329376 G/C cg18551225 chr6:44695536 NA -0.44 -7.22 -0.37 3.52e-12 Total body bone mineral density; LUSC trans rs7939886 0.920 rs77391761 chr11:55814896 G/C cg03929089 chr4:120376271 NA 0.77 6.33 0.33 8e-10 Myopia (pathological); LUSC cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs240764 0.658 rs7746961 chr6:101215244 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.26 -0.32 1.21e-9 Neuroticism; LUSC trans rs1997103 1.000 rs9642578 chr7:55400320 A/G cg20935933 chr6:143382018 AIG1 0.51 7.35 0.37 1.5e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs13082711 0.911 rs4973769 chr3:27425746 T/C cg02860705 chr3:27208620 NA 0.49 8.38 0.42 1.53e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7659604 0.502 rs13106764 chr4:122699630 C/G cg06713675 chr4:122721982 EXOSC9 0.38 6.24 0.32 1.3e-9 Type 2 diabetes; LUSC cis rs7818345 0.967 rs4481612 chr8:19285336 T/G cg11303988 chr8:19266685 CSGALNACT1 0.35 6.7 0.34 8.83e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs308403 0.608 rs309368 chr4:123662997 A/T cg10495464 chr4:123653540 BBS12;LOC729338 0.83 10.96 0.51 4.31e-24 Blood protein levels; LUSC cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.63 -0.34 1.33e-10 Arsenic metabolism; LUSC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg18876405 chr7:65276391 NA 0.54 8.46 0.42 8.32e-16 Aortic root size; LUSC cis rs34172651 0.917 rs200538 chr16:24735736 C/T cg00339695 chr16:24857497 SLC5A11 -0.37 -6.46 -0.33 3.69e-10 Intelligence (multi-trait analysis); LUSC cis rs3857067 1.000 rs3857067 chr4:95026434 A/T cg11021082 chr4:95130006 SMARCAD1 -0.3 -5.65 -0.3 3.47e-8 QT interval; LUSC cis rs6940638 0.688 rs9379960 chr6:27121325 A/C cg12826209 chr6:26865740 GUSBL1 0.52 7.42 0.38 9.51e-13 Intelligence (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg01523759 chr16:89202603 ACSF3 -0.44 -6.94 -0.36 2.03e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg05896524 chr21:47604654 C21orf56 0.56 8.78 0.43 8.75e-17 Testicular germ cell tumor; LUSC cis rs73198271 0.694 rs73201840 chr8:8647067 G/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.32 -0.33 8.29e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg26243475 chr13:51484009 RNASEH2B 0.46 6.01 0.31 4.76e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9612 1.000 rs346527 chr19:44259361 A/G cg08581076 chr19:44259116 C19orf61 0.53 6.66 0.34 1.1e-10 Exhaled nitric oxide output; LUSC trans rs9650657 0.665 rs1897207 chr8:10615235 C/T cg15556689 chr8:8085844 FLJ10661 -0.42 -6.27 -0.32 1.14e-9 Neuroticism; LUSC cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg17366294 chr4:99064904 C4orf37 0.58 9.89 0.48 2.08e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg13854012 chr2:162103682 NA -0.45 -7.97 -0.4 2.53e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs1775715 0.737 rs2799015 chr10:32107712 C/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.58 0.34 1.8e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11039100 0.607 rs11038946 chr11:5779859 C/T cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12541635 0.966 rs6469028 chr8:107014552 C/T cg10147462 chr8:107024639 NA 0.55 9.85 0.47 3.01e-20 Age of smoking initiation; LUSC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 5.92 0.31 8.08e-9 Parkinson's disease; LUSC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg15494558 chr6:150152522 LRP11 0.34 5.77 0.3 1.77e-8 Lung cancer; LUSC cis rs977987 0.843 rs4888372 chr16:75313485 G/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.82 -0.35 4.32e-11 Dupuytren's disease; LUSC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg06637938 chr14:75390232 RPS6KL1 -0.51 -8.02 -0.4 1.8e-14 Height; LUSC cis rs6424115 0.830 rs2501425 chr1:24199339 A/C cg10978503 chr1:24200527 CNR2 0.54 13.21 0.59 2.32e-32 Immature fraction of reticulocytes; LUSC cis rs10823500 0.777 rs10762348 chr10:71952322 C/A cg02100629 chr10:71892760 AIFM2 -0.38 -6.07 -0.32 3.43e-9 Blood protein levels; LUSC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg18758796 chr5:131593413 PDLIM4 0.34 5.83 0.3 1.31e-8 Blood metabolite levels; LUSC cis rs9467711 0.606 rs67509210 chr6:26354100 G/T cg14345882 chr6:26364793 BTN3A2 0.6 5.69 0.3 2.81e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg08213375 chr14:104286397 PPP1R13B 0.46 9.0 0.44 1.8e-17 Schizophrenia; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg13397359 chr6:42928475 GNMT 0.58 9.85 0.47 2.9e-20 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11231629 1 rs11231629 chr11:63648573 C/T cg04850017 chr11:63683019 RCOR2 0.37 7.56 0.38 3.92e-13 Schizophrenia; LUSC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.01e-9 Life satisfaction; LUSC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg05347473 chr6:146136440 FBXO30 -0.55 -9.43 -0.46 7.02e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.02 -0.31 4.69e-9 Platelet count; LUSC cis rs11711311 1.000 rs2566963 chr3:113531849 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.5 -6.78 -0.35 5.4e-11 IgG glycosylation; LUSC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.27 0.32 1.14e-9 Mean platelet volume; LUSC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg11764359 chr7:65958608 NA -0.71 -11.04 -0.52 2.31e-24 Aortic root size; LUSC cis rs7605827 0.930 rs7602186 chr2:15510003 C/T cg19274914 chr2:15703543 NA 0.45 8.77 0.43 9.38e-17 Educational attainment (years of education); LUSC cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg18876405 chr7:65276391 NA -0.56 -8.67 -0.43 1.96e-16 Aortic root size; LUSC cis rs7809950 0.724 rs1858888 chr7:107046062 T/A cg23024343 chr7:107201750 COG5 -0.7 -10.11 -0.48 3.99e-21 Coronary artery disease; LUSC cis rs492146 0.740 rs1032418 chr6:52834957 A/T cg24393602 chr6:52860404 GSTA4 0.4 5.82 0.3 1.36e-8 Epilepsy (remission after treatment); LUSC cis rs11155671 0.530 rs4870080 chr6:150202644 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.84 -0.3 1.21e-8 Testicular germ cell tumor; LUSC cis rs6681460 0.932 rs4655640 chr1:67089220 T/C cg02459107 chr1:67143332 SGIP1 0.46 8.42 0.42 1.15e-15 Presence of antiphospholipid antibodies; LUSC cis rs6484504 0.600 rs2761593 chr11:31326752 G/T cg06552810 chr11:31128660 NA 0.39 6.85 0.35 3.49e-11 Red blood cell count; LUSC cis rs7560272 0.588 rs4852959 chr2:73880601 C/A cg20560298 chr2:73613845 ALMS1 0.44 6.67 0.34 1.07e-10 Schizophrenia; LUSC trans rs637571 0.584 rs659824 chr11:65636509 A/G cg17712092 chr4:129076599 LARP1B -0.78 -11.91 -0.55 1.7e-27 Eosinophil percentage of white cells; LUSC cis rs17270561 0.887 rs9358870 chr6:25719210 T/C cg16482183 chr6:26056742 HIST1H1C 0.7 8.3 0.41 2.61e-15 Iron status biomarkers; LUSC cis rs3125734 0.608 rs7905731 chr10:64018472 T/C cg09941381 chr10:64027924 RTKN2 -0.38 -7.01 -0.36 1.31e-11 Rheumatoid arthritis; LUSC trans rs10432489 0.708 rs3922471 chr2:181771937 T/C cg11196870 chr8:41386826 GINS4 0.93 6.32 0.33 8.44e-10 QT interval; LUSC cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg08355456 chr11:67383691 NA -0.37 -6.55 -0.34 2.19e-10 Mean corpuscular volume; LUSC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 10.0 0.48 8.85e-21 Personality dimensions; LUSC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.47 5.68 0.3 2.87e-8 Renal function-related traits (BUN); LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.62 0.34 1.46e-10 Obesity-related traits; LUSC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg26597838 chr10:835615 NA 0.78 9.46 0.46 5.75e-19 Eosinophil percentage of granulocytes; LUSC cis rs6545883 0.868 rs6545887 chr2:61828818 C/G cg15711740 chr2:61764176 XPO1 -0.46 -7.31 -0.37 1.98e-12 Tuberculosis; LUSC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg17366294 chr4:99064904 C4orf37 0.56 9.96 0.48 1.2e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs950169 0.922 rs11635505 chr15:85097034 A/C cg11189052 chr15:85197271 WDR73 -0.46 -5.8 -0.3 1.57e-8 Schizophrenia; LUSC cis rs1185460 1.000 rs1784305 chr11:118942048 G/A cg23280166 chr11:118938394 VPS11 0.45 6.89 0.35 2.82e-11 Coronary artery disease; LUSC cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg16240275 chr20:61666158 NCRNA00029 0.41 8.95 0.44 2.43e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs72781680 0.898 rs17462558 chr2:24020812 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs4293296 0.525 rs28429558 chr14:54827875 A/G cg02257953 chr14:54816093 NA -0.44 -6.19 -0.32 1.78e-9 Response to antipsychotic treatment in schizophrenia (working memory); LUSC trans rs2243480 1.000 rs437889 chr7:65509234 G/A cg10756647 chr7:56101905 PSPH 0.87 8.48 0.42 7.16e-16 Diabetic kidney disease; LUSC cis rs500891 0.645 rs1180189 chr6:83966928 A/T cg08257003 chr6:84140564 ME1 0.3 6.7 0.34 8.8e-11 Platelet-derived growth factor BB levels; LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03934478 chr11:495069 RNH1 0.79 8.95 0.44 2.5e-17 Body mass index; LUSC trans rs7939886 0.920 rs7946368 chr11:55804219 C/T cg15704280 chr7:45808275 SEPT13 0.8 6.88 0.35 3.04e-11 Myopia (pathological); LUSC cis rs9611519 0.894 rs9611486 chr22:41458784 C/G cg03806693 chr22:41940476 POLR3H -0.54 -7.28 -0.37 2.4e-12 Neuroticism; LUSC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -5.86 -0.31 1.11e-8 Tonsillectomy; LUSC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg19920283 chr7:105172520 RINT1 0.61 6.67 0.34 1.07e-10 Bipolar disorder (body mass index interaction); LUSC cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg06627628 chr2:24431161 ITSN2 -0.61 -7.4 -0.38 1.09e-12 Lymphocyte counts; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg11060661 chr22:24314208 DDT;DDTL 0.47 7.27 0.37 2.58e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg11062466 chr8:58055876 NA 0.76 9.04 0.44 1.31e-17 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.617 rs73170169 chr7:150008036 G/A cg27494647 chr7:150038898 RARRES2 0.53 8.0 0.4 2e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs12900413 0.562 rs28450767 chr15:90298228 A/G cg24249390 chr15:90295951 MESP1 -0.38 -5.95 -0.31 6.73e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs939658 1.000 rs11072826 chr15:79461516 C/T cg17916960 chr15:79447300 NA 0.52 10.5 0.5 1.8e-22 Refractive error; LUSC cis rs6121246 0.909 rs6088962 chr20:30268184 C/T cg21427119 chr20:30132790 HM13 -0.39 -5.73 -0.3 2.25e-8 Mean corpuscular hemoglobin; LUSC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg18512352 chr11:47633146 NA 0.47 9.41 0.46 8.43e-19 Subjective well-being; LUSC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.12 -0.72 1.42e-55 Height; LUSC cis rs79387448 0.745 rs17027341 chr2:103136559 A/G cg09003973 chr2:102972529 NA 0.86 8.61 0.43 3.03e-16 Gut microbiota (bacterial taxa); LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.53 -7.88 -0.4 4.6e-14 Lymphocyte counts; LUSC trans rs57046232 0.552 rs1998971 chr20:6334912 G/A cg17788362 chr6:86352627 SYNCRIP 0.42 6.1 0.32 2.95e-9 Colorectal cancer; LUSC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg21573476 chr21:45109991 RRP1B -0.4 -6.36 -0.33 6.5e-10 Mean corpuscular volume; LUSC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22590775 chr19:49891494 CCDC155 0.61 8.9 0.44 3.74e-17 Multiple sclerosis; LUSC cis rs12249377 0.519 rs10785972 chr10:92593800 C/T cg14313238 chr10:92632228 RPP30 0.42 5.76 0.3 1.87e-8 White matter microstructure (global fractional anisotropy); LUSC cis rs999943 0.846 rs9366826 chr6:33619184 C/G cg14003231 chr6:33640908 ITPR3 0.61 11.41 0.53 1.09e-25 Obesity (extreme); LUSC cis rs10876993 0.680 rs2277322 chr12:58009202 T/C cg15848620 chr12:58087721 OS9 0.45 6.28 0.33 1.05e-9 Celiac disease or Rheumatoid arthritis; LUSC cis rs10986311 0.802 rs7045589 chr9:127110354 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.45 7.4 0.38 1.14e-12 Vitiligo; LUSC cis rs34172651 0.797 rs12920941 chr16:24830866 T/A cg06028605 chr16:24865363 SLC5A11 0.46 8.2 0.41 5.17e-15 Intelligence (multi-trait analysis); LUSC cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg14530993 chr4:882597 GAK 0.75 7.15 0.36 5.42e-12 Intelligence (multi-trait analysis); LUSC cis rs4808199 0.948 rs1859287 chr19:19422187 T/C cg03709012 chr19:19516395 GATAD2A 0.95 11.68 0.54 1.14e-26 Nonalcoholic fatty liver disease; LUSC cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg05294307 chr14:35346193 BAZ1A -0.61 -7.38 -0.37 1.23e-12 Psoriasis; LUSC cis rs6138458 1.000 rs227630 chr20:24913584 A/G cg06937882 chr20:24974362 C20orf3 -0.43 -7.41 -0.38 1.04e-12 Blood protein levels; LUSC cis rs9309473 0.607 rs6546824 chr2:73587331 G/A cg20560298 chr2:73613845 ALMS1 -0.56 -8.25 -0.41 3.61e-15 Metabolite levels; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg27588902 chr6:42928151 GNMT -0.3 -6.66 -0.34 1.14e-10 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09468767 chr5:159848851 PTTG1 -0.4 -6.02 -0.31 4.52e-9 Electrocardiographic conduction measures; LUSC cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg26384229 chr12:38710491 ALG10B 0.87 14.84 0.63 1.29e-38 Bladder cancer; LUSC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11890956 chr21:40555474 PSMG1 -1.03 -19.85 -0.74 1.83e-58 Cognitive function; LUSC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg11764359 chr7:65958608 NA 0.81 13.52 0.59 1.62e-33 Aortic root size; LUSC cis rs79387448 0.745 rs7583683 chr2:103113763 C/T cg09003973 chr2:102972529 NA -0.88 -8.77 -0.43 9.45e-17 Gut microbiota (bacterial taxa); LUSC cis rs7181230 1.000 rs9972424 chr15:40365851 A/G cg00868766 chr15:40364524 NA 0.34 5.92 0.31 7.8e-9 Dehydroepiandrosterone sulphate levels; LUSC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg11764359 chr7:65958608 NA 0.52 6.71 0.34 8.37e-11 Aortic root size; LUSC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg10295955 chr4:187884368 NA -1.04 -24.31 -0.8 6.97e-76 Lobe attachment (rater-scored or self-reported); LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg06877462 chr1:205807181 PM20D1 0.34 6.19 0.32 1.81e-9 Monocyte percentage of white cells; LUSC cis rs11690935 0.655 rs12997093 chr2:172564438 A/G cg13550731 chr2:172543902 DYNC1I2 0.59 9.35 0.46 1.34e-18 Schizophrenia; LUSC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg22535103 chr8:58192502 C8orf71 -0.82 -10.08 -0.48 4.74e-21 Developmental language disorder (linguistic errors); LUSC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg01579765 chr21:45077557 HSF2BP -0.55 -11.77 -0.54 5.61e-27 Mean corpuscular volume; LUSC cis rs12421382 0.593 rs2118973 chr11:109389231 G/A cg11473876 chr11:109292803 C11orf87 0.35 5.97 0.31 5.95e-9 Schizophrenia; LUSC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.02e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -8.31 -0.41 2.37e-15 Alzheimer's disease; LUSC cis rs929354 0.772 rs3802125 chr7:156970563 A/C cg05182265 chr7:156933206 UBE3C -0.6 -9.67 -0.47 1.11e-19 Body mass index; LUSC trans rs7824557 0.564 rs2437152 chr8:11235497 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.01e-14 Retinal vascular caliber; LUSC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg13393036 chr8:95962371 TP53INP1 -0.52 -11.05 -0.52 2.05e-24 Type 2 diabetes; LUSC trans rs12310956 0.532 rs1352209 chr12:33983408 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.83 0.51 1.22e-23 Morning vs. evening chronotype; LUSC cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg03264133 chr6:25882463 NA -0.34 -5.7 -0.3 2.61e-8 Height; LUSC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs4072705 0.646 rs10120967 chr9:127244134 C/T cg13476313 chr9:127244764 NR5A1 0.35 6.89 0.35 2.81e-11 Menarche (age at onset); LUSC cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.67 0.6 4.14e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4363385 0.510 rs2068678 chr1:152906956 G/A cg00922841 chr1:152955080 SPRR1A -0.37 -5.95 -0.31 6.9e-9 Inflammatory skin disease; LUSC cis rs6464929 0.911 rs6965276 chr7:148724505 G/A cg23583168 chr7:148888333 NA 0.46 5.87 0.31 1.07e-8 Pediatric bone mineral content (hip); LUSC cis rs7267979 0.932 rs6115200 chr20:25487377 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.96 0.7 5.99e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg04455712 chr21:45112962 RRP1B 0.45 8.46 0.42 8.73e-16 Mean corpuscular volume; LUSC cis rs997295 0.554 rs7180312 chr15:68105256 G/A cg08079166 chr15:68083412 MAP2K5 0.37 7.65 0.39 2.19e-13 Motion sickness; LUSC cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.69 -0.5 4.05e-23 Schizophrenia; LUSC cis rs12210905 0.614 rs12199685 chr6:27323486 G/A cg08851530 chr6:28072375 NA 0.9 5.78 0.3 1.75e-8 Hip circumference adjusted for BMI; LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18404041 chr3:52824283 ITIH1 -0.5 -9.39 -0.46 9.65e-19 Bipolar disorder; LUSC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.04 -0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg24531977 chr5:56204891 C5orf35 -0.57 -8.52 -0.42 5.73e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg08048268 chr3:133502702 NA -0.49 -9.55 -0.46 2.94e-19 Iron status biomarkers; LUSC cis rs804280 0.509 rs13276433 chr8:11783036 A/G cg00405596 chr8:11794950 NA 0.36 6.02 0.31 4.62e-9 Myopia (pathological); LUSC cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.72 0.34 8.05e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9902453 0.808 rs12452288 chr17:28235220 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 10.03 0.48 7.42e-21 Coffee consumption (cups per day); LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg13047869 chr3:10149882 C3orf24 -0.61 -8.12 -0.41 8.92e-15 Alzheimer's disease; LUSC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg10207240 chr12:122356781 WDR66 0.47 6.64 0.34 1.29e-10 Mean corpuscular volume; LUSC cis rs12701220 0.690 rs10243973 chr7:1064983 T/C cg26769984 chr7:1090371 C7orf50 0.67 9.94 0.48 1.4e-20 Bronchopulmonary dysplasia; LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -8.71 -0.43 1.4e-16 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 7.64 0.39 2.31e-13 Diabetic retinopathy; LUSC cis rs7577696 0.925 rs7573543 chr2:32342508 A/T cg02381751 chr2:32503542 YIPF4 -0.4 -5.7 -0.3 2.7e-8 Inflammatory biomarkers; LUSC cis rs1799949 0.965 rs8071278 chr17:41193910 A/T cg25072359 chr17:41440525 NA 0.65 9.35 0.46 1.28e-18 Menopause (age at onset); LUSC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg26384229 chr12:38710491 ALG10B 0.87 14.68 0.63 5.27e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs317689 0.600 rs478863 chr12:69639207 G/A cg11871910 chr12:69753446 YEATS4 0.45 5.83 0.3 1.3e-8 Response to diuretic therapy; LUSC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg14582100 chr15:45693742 SPATA5L1 -0.57 -10.3 -0.49 8.96e-22 Homoarginine levels; LUSC trans rs8002861 0.935 rs1819595 chr13:44429716 T/A cg12856521 chr11:46389249 DGKZ 0.39 6.34 0.33 7.44e-10 Leprosy; LUSC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2717559 0.542 rs34147336 chr8:143884869 A/G cg02415014 chr8:143852576 LYNX1 0.32 7.59 0.38 3.22e-13 Urinary tract infection frequency; LUSC cis rs950027 0.620 rs1719246 chr15:45625479 T/A cg26924012 chr15:45694286 SPATA5L1 0.77 12.26 0.56 8.62e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs68170813 0.652 rs6958969 chr7:107197755 A/T cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.66 -0.3 3.23e-8 Coronary artery disease; LUSC cis rs738321 0.757 rs5750546 chr22:38542499 C/T cg25457927 chr22:38595422 NA -0.42 -8.01 -0.4 1.93e-14 Breast cancer; LUSC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg18305652 chr10:134549665 INPP5A 0.46 6.83 0.35 4.01e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs3768617 0.811 rs34721094 chr1:183051521 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.75 0.43 1.08e-16 Fuchs's corneal dystrophy; LUSC cis rs2361710 0.669 rs12940486 chr17:78118569 T/C cg06718696 chr17:78121285 EIF4A3 0.44 6.29 0.33 9.77e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs9815354 1.000 rs73079321 chr3:41863910 C/T cg03022575 chr3:42003672 ULK4 0.58 6.52 0.34 2.6e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg01943577 chr7:158741284 NA -0.44 -6.88 -0.35 2.96e-11 Height; LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg10546459 chr2:36825355 FEZ2 0.52 7.55 0.38 4.08e-13 Height; LUSC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg15445000 chr17:37608096 MED1 0.39 6.63 0.34 1.35e-10 Glomerular filtration rate (creatinine); LUSC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg23711669 chr6:146136114 FBXO30 0.83 15.34 0.64 1.48e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.623 rs72760941 chr10:1141244 A/G cg26597838 chr10:835615 NA 0.53 6.42 0.33 4.72e-10 Eosinophil percentage of granulocytes; LUSC trans rs57221529 0.766 rs1399381 chr5:589853 G/T cg11887960 chr12:57824829 NA 0.55 6.69 0.34 9.64e-11 Lung disease severity in cystic fibrosis; LUSC cis rs4713675 0.565 rs9469566 chr6:33667605 G/T cg14003231 chr6:33640908 ITPR3 0.31 5.93 0.31 7.5e-9 Plateletcrit; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg16606324 chr3:10149918 C3orf24 -0.62 -9.58 -0.46 2.34e-19 Alzheimer's disease; LUSC cis rs7909074 1.000 rs7909074 chr10:45395839 G/A cg04218760 chr10:45406644 TMEM72 -0.3 -7.35 -0.37 1.57e-12 Mean corpuscular volume; LUSC trans rs877282 1.000 rs12763443 chr10:771941 G/A cg22713356 chr15:30763199 NA 1.12 15.56 0.65 1.87e-41 Uric acid levels; LUSC cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg05347473 chr6:146136440 FBXO30 0.45 7.61 0.38 2.74e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16457196 chr5:176944438 DDX41 -0.46 -5.98 -0.31 5.75e-9 Bipolar disorder and schizophrenia; LUSC cis rs56161922 0.818 rs111340461 chr1:207870682 A/C cg11752769 chr1:207818423 CR1L -0.7 -5.91 -0.31 8.43e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs6456156 0.586 rs1358882 chr6:167467101 G/A cg25258033 chr6:167368657 RNASET2 0.36 5.73 0.3 2.28e-8 Primary biliary cholangitis; LUSC cis rs59698941 0.943 rs17691542 chr5:132279227 T/C cg02081065 chr5:132209139 LEAP2 -0.6 -5.82 -0.3 1.4e-8 Apolipoprotein A-IV levels; LUSC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg19812747 chr11:111475976 SIK2 -0.52 -7.26 -0.37 2.67e-12 Primary sclerosing cholangitis; LUSC cis rs4343996 0.967 rs10260145 chr7:3345308 C/T cg21248987 chr7:3385318 SDK1 0.4 6.8 0.35 4.77e-11 Motion sickness; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs870825 0.929 rs2310102 chr4:185595141 C/G cg04058563 chr4:185651563 MLF1IP -0.78 -11.09 -0.52 1.52e-24 Blood protein levels; LUSC cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg04450456 chr4:17643702 FAM184B 0.41 6.98 0.36 1.62e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg12560992 chr17:57184187 TRIM37 -0.84 -15.48 -0.65 3.83e-41 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg04414720 chr1:150670196 GOLPH3L 0.5 7.71 0.39 1.45e-13 Melanoma; LUSC cis rs7267979 0.966 rs2261794 chr20:25263062 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.49 0.75 5.16e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs17253792 0.555 rs17683626 chr14:56041112 G/T cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs9300255 0.544 rs1790130 chr12:123701270 A/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs2658782 0.826 rs2925355 chr11:93090887 T/C cg15737290 chr11:93063684 CCDC67 0.68 8.22 0.41 4.45e-15 Pulmonary function decline; LUSC cis rs2617583 0.509 rs62331137 chr5:1459573 A/G cg13982541 chr5:1466431 LPCAT1 0.43 6.17 0.32 1.94e-9 Breast cancer; LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg04267008 chr7:1944627 MAD1L1 -0.49 -7.11 -0.36 6.96e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs96067 0.711 rs11263861 chr1:36628033 G/A cg24686825 chr1:36642396 MAP7D1 -0.6 -9.31 -0.45 1.73e-18 Corneal structure; LUSC cis rs5756813 0.688 rs8140207 chr22:38130459 G/T cg06521852 chr22:38141419 TRIOBP 0.39 5.9 0.31 9.05e-9 Optic cup area;Vertical cup-disc ratio; LUSC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.81 12.1 0.55 3.33e-28 Cognitive test performance; LUSC cis rs1997103 0.911 rs10238738 chr7:55412359 T/C cg17469321 chr7:55412551 NA 0.65 10.53 0.5 1.45e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10197940 0.578 rs2432946 chr2:152306897 G/T cg06191203 chr2:152266755 RIF1 0.41 5.64 0.3 3.58e-8 Lung cancer; LUSC cis rs9616064 0.557 rs9615397 chr22:47049086 C/T cg05621596 chr22:47072043 GRAMD4 -0.54 -8.55 -0.42 4.43e-16 Urate levels in obese individuals; LUSC cis rs9398803 0.965 rs6907898 chr6:126666416 C/T cg19875578 chr6:126661172 C6orf173 0.41 6.12 0.32 2.66e-9 Male-pattern baldness; LUSC trans rs1728785 1.000 rs1728801 chr16:68571457 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs7267979 1.000 rs4813563 chr20:25365340 T/C cg08601574 chr20:25228251 PYGB -0.44 -6.79 -0.35 5.29e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC trans rs1728785 0.901 rs1183956 chr16:68606726 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs477692 0.685 rs551491 chr10:131397821 G/A cg26102564 chr10:131424627 MGMT 0.41 6.34 0.33 7.38e-10 Response to temozolomide; LUSC cis rs9359856 0.518 rs11965790 chr6:90261621 C/T cg13799429 chr6:90582589 CASP8AP2 -0.59 -6.19 -0.32 1.75e-9 Bipolar disorder; LUSC cis rs1348850 0.632 rs12616288 chr2:178503813 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 6.02 0.31 4.7e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs936229 0.813 rs8033381 chr15:75080685 G/A cg14664628 chr15:75095509 CSK -1.01 -17.32 -0.69 2.09e-48 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs853679 0.546 rs35819751 chr6:27810569 A/G cg01620082 chr3:125678407 NA -0.83 -7.35 -0.37 1.56e-12 Depression; LUSC cis rs7580658 0.926 rs4662725 chr2:128141320 G/A cg09760422 chr2:128146352 NA -0.33 -7.25 -0.37 2.91e-12 Protein C levels; LUSC cis rs77741769 0.571 rs73415720 chr12:121344515 T/C cg02419362 chr12:121203948 SPPL3 0.45 8.29 0.41 2.85e-15 Mean corpuscular volume; LUSC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg10755058 chr3:40428713 ENTPD3 0.35 5.97 0.31 6.05e-9 Renal cell carcinoma; LUSC cis rs11190604 0.767 rs7392696 chr10:102182141 G/A cg07080220 chr10:102295463 HIF1AN 0.59 7.86 0.4 5.23e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg08859206 chr1:53392774 SCP2 -0.48 -8.14 -0.41 7.75e-15 Monocyte count; LUSC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg12963246 chr6:28129442 ZNF389 0.38 5.73 0.3 2.28e-8 Cardiac Troponin-T levels; LUSC cis rs17685 0.712 rs10235738 chr7:75773460 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.54 -8.23 -0.41 4.13e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1832871 0.965 rs861179 chr6:158712720 A/G cg07165851 chr6:158734300 TULP4 0.37 6.37 0.33 6.31e-10 Height; LUSC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.37 0.59 6.04e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9633740 0.578 rs11185982 chr10:82305627 C/T cg01528321 chr10:82214614 TSPAN14 0.73 6.95 0.36 1.91e-11 Post bronchodilator FEV1; LUSC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.65 -9.74 -0.47 6.74e-20 Hip circumference adjusted for BMI; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg22903657 chr4:1355424 KIAA1530 -0.36 -6.02 -0.31 4.68e-9 Obesity-related traits; LUSC trans rs3808502 0.605 rs11784572 chr8:11174484 C/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.24 -0.37 3.17e-12 Neuroticism; LUSC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg12560992 chr17:57184187 TRIM37 0.85 15.26 0.64 3e-40 Intelligence (multi-trait analysis); LUSC cis rs8078723 0.677 rs11658328 chr17:38149236 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.37 0.37 1.39e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg03452623 chr4:187889614 NA -0.88 -18.2 -0.71 6.32e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg04362960 chr10:104952993 NT5C2 0.6 9.4 0.46 8.93e-19 Arsenic metabolism; LUSC cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg08999081 chr20:33150536 PIGU 0.53 10.57 0.5 1e-22 Glomerular filtration rate (creatinine); LUSC cis rs62432291 0.681 rs420054 chr6:159655084 C/G cg14500486 chr6:159655392 FNDC1 -0.52 -5.86 -0.31 1.09e-8 Joint mobility (Beighton score); LUSC cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.84 -0.44 5.72e-17 Axial length; LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg16145915 chr7:1198662 ZFAND2A -0.45 -8.02 -0.4 1.74e-14 Longevity;Endometriosis; LUSC trans rs475616 1.000 rs2795863 chr10:30500267 C/T cg02841571 chr6:169977833 WDR27 0.41 6.0 0.31 5.01e-9 Monocyte count; LUSC cis rs78366141 0.649 rs61737091 chr4:89671721 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.96 7.68 0.39 1.82e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs12493885 0.725 rs61793489 chr3:153731156 T/C cg17054900 chr3:154042577 DHX36 -0.7 -7.28 -0.37 2.4e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3806843 0.576 rs246032 chr5:140332547 C/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg15790184 chr11:494944 RNH1 0.5 7.82 0.39 6.93e-14 Systemic lupus erythematosus; LUSC cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg23788917 chr6:8435910 SLC35B3 0.5 7.48 0.38 6.59e-13 Motion sickness; LUSC cis rs12618769 0.597 rs12617721 chr2:99083892 G/T cg10123293 chr2:99228465 UNC50 -0.46 -7.69 -0.39 1.7e-13 Bipolar disorder; LUSC cis rs73206853 0.841 rs57726856 chr12:110961123 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 7.83e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg06784218 chr1:46089804 CCDC17 0.51 10.18 0.49 2.28e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2219968 0.828 rs10102662 chr8:78906075 C/T cg00738934 chr8:78996279 NA 0.34 6.01 0.31 4.99e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg21770322 chr7:97807741 LMTK2 0.53 9.42 0.46 7.44e-19 Breast cancer; LUSC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg00343986 chr7:65444356 GUSB -0.39 -5.81 -0.3 1.48e-8 Calcium levels; LUSC cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 20.08 0.74 2.32e-59 Cognitive ability; LUSC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.06e-8 Major depressive disorder; LUSC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg08439880 chr3:133502540 NA -0.4 -7.32 -0.37 1.83e-12 Iron status biomarkers; LUSC trans rs2197308 0.765 rs7295711 chr12:37903631 C/T cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs10276303 0.519 rs11983447 chr7:3399423 T/A cg21248987 chr7:3385318 SDK1 -0.39 -6.52 -0.34 2.6e-10 Dupuytren's disease; LUSC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg17211192 chr8:82754475 SNX16 -0.76 -10.05 -0.48 6.13e-21 Diastolic blood pressure; LUSC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg03605463 chr16:89740564 NA 0.59 9.22 0.45 3.39e-18 Vitiligo; LUSC cis rs17780086 0.527 rs72827711 chr17:30537920 T/A cg00745463 chr17:30367425 LRRC37B -0.83 -7.92 -0.4 3.48e-14 Height; LUSC cis rs735396 0.965 rs2257962 chr12:121445808 T/C cg02403541 chr12:121454288 C12orf43 0.59 8.46 0.42 8.6e-16 N-glycan levels; LUSC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg13206674 chr6:150067644 NUP43 0.6 9.62 0.47 1.67e-19 Lung cancer; LUSC cis rs2011503 0.941 rs10422893 chr19:19372185 G/C cg11244672 chr19:19639970 YJEFN3 -0.52 -6.49 -0.33 3.05e-10 Bipolar disorder; LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg02951883 chr7:2050386 MAD1L1 -0.51 -9.03 -0.44 1.42e-17 Bipolar disorder and schizophrenia; LUSC cis rs7647973 0.925 rs9834003 chr3:49216472 T/C cg07636037 chr3:49044803 WDR6 0.69 8.83 0.43 6.21e-17 Menarche (age at onset); LUSC cis rs1044826 0.518 rs295488 chr3:139239323 C/T cg00490450 chr3:139108681 COPB2 0.53 8.24 0.41 3.94e-15 Obesity-related traits; LUSC trans rs800082 1.000 rs9849975 chr3:144294530 A/G cg24215973 chr2:240111563 HDAC4 -0.47 -7.16 -0.36 5.28e-12 Smoking behavior; LUSC cis rs208515 0.518 rs12209790 chr6:66662965 T/C cg07460842 chr6:66804631 NA 1.04 14.11 0.61 9.12e-36 Exhaled nitric oxide levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11818790 chr22:42196598 CCDC134 -0.42 -6.25 -0.32 1.23e-9 Electrocardiographic conduction measures; LUSC cis rs7586879 0.861 rs10164466 chr2:25114069 T/C cg15423357 chr2:25149977 NA 0.32 5.77 0.3 1.82e-8 Body mass index; LUSC cis rs56399783 0.614 rs55776032 chr7:2762255 T/C cg14895029 chr7:2775587 GNA12 0.55 5.93 0.31 7.66e-9 Childhood ear infection; LUSC cis rs2073300 0.609 rs6132615 chr20:23413200 T/C cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg13010344 chr12:123464640 ARL6IP4 -0.5 -6.77 -0.35 5.66e-11 Neutrophil percentage of white cells; LUSC cis rs7296418 0.922 rs1727293 chr12:123648032 C/T cg13010344 chr12:123464640 ARL6IP4 -0.52 -8.28 -0.41 2.91e-15 Platelet count; LUSC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg24399712 chr22:39784796 NA -0.62 -11.12 -0.52 1.19e-24 Intelligence (multi-trait analysis); LUSC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg05802129 chr4:122689817 NA -0.37 -6.69 -0.34 9.68e-11 Type 2 diabetes; LUSC cis rs9354352 0.967 rs9354351 chr6:66696271 G/A cg07460842 chr6:66804631 NA 0.68 9.95 0.48 1.33e-20 Initial pursuit acceleration in psychotic disorders; LUSC cis rs6554196 0.508 rs2237038 chr4:55525833 C/T cg18836493 chr4:55524333 KIT 0.43 7.01 0.36 1.36e-11 Monocyte count; LUSC cis rs11608355 0.597 rs10850070 chr12:109793882 A/G cg19025524 chr12:109796872 NA -0.49 -9.19 -0.45 4.27e-18 Neuroticism; LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.69 -11.07 -0.52 1.76e-24 Prudent dietary pattern; LUSC cis rs7597155 0.967 rs4852995 chr2:69983663 G/C cg02498382 chr2:70120550 SNRNP27 -0.24 -5.69 -0.3 2.76e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.02 0.31 4.51e-9 Schizophrenia; LUSC trans rs62103177 0.608 rs613847 chr18:77845644 A/G cg14227996 chr4:17616232 MED28 -0.54 -6.06 -0.31 3.69e-9 Opioid sensitivity; LUSC trans rs10432489 0.708 rs6730421 chr2:181755815 A/G cg25678491 chr13:101327172 TMTC4 -0.78 -6.38 -0.33 5.97e-10 QT interval; LUSC cis rs6901250 0.788 rs591794 chr6:117089018 G/A cg12892004 chr6:117198278 RFX6 0.41 7.42 0.38 9.5e-13 C-reactive protein levels; LUSC trans rs561341 0.941 rs2428341 chr17:30317295 C/T cg20587970 chr11:113659929 NA -1.04 -13.97 -0.61 3.13e-35 Hip circumference adjusted for BMI; LUSC cis rs13256369 0.802 rs11781257 chr8:8559663 A/T cg06671706 chr8:8559999 CLDN23 0.5 6.49 0.33 3.18e-10 Obesity-related traits; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg09177884 chr7:1199841 ZFAND2A -0.58 -8.09 -0.4 1.14e-14 Longevity;Endometriosis; LUSC cis rs9790314 0.663 rs4557202 chr3:160820524 G/C cg03342759 chr3:160939853 NMD3 -0.42 -6.78 -0.35 5.43e-11 Morning vs. evening chronotype; LUSC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.04 0.58 1.03e-31 Platelet count; LUSC cis rs1577917 0.876 rs66986937 chr6:86532191 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.82 -0.43 6.58e-17 Response to antipsychotic treatment; LUSC trans rs1941687 0.505 rs12605642 chr18:31313965 G/T cg13755796 chr4:20253514 NA -0.39 -6.06 -0.31 3.75e-9 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7106204 0.748 rs6484031 chr11:24237115 A/C ch.11.24196551F chr11:24239977 NA 1.16 14.62 0.62 8.9e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg05802129 chr4:122689817 NA -0.34 -5.98 -0.31 5.62e-9 Type 2 diabetes; LUSC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg11344533 chr11:111475393 SIK2 -0.49 -6.89 -0.35 2.86e-11 Primary sclerosing cholangitis; LUSC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg13628971 chr7:2884303 GNA12 0.49 7.24 0.37 3.12e-12 Height; LUSC cis rs11608355 0.545 rs12819658 chr12:109907670 A/T cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.03 -0.31 4.27e-9 Major depressive disorder; LUSC cis rs7618501 1.000 rs7649348 chr3:49772375 G/A cg12257692 chr3:49977190 RBM6 -0.21 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg08332330 chr12:125549884 AACS 0.41 6.35 0.33 7.09e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg13390004 chr1:15929781 NA 0.4 6.81 0.35 4.66e-11 Systolic blood pressure; LUSC cis rs1801251 0.778 rs812383 chr2:233737132 C/A cg08000102 chr2:233561755 GIGYF2 -0.5 -7.76 -0.39 1.04e-13 Coronary artery disease; LUSC cis rs8114671 0.967 rs6058202 chr20:33777983 A/G cg24642439 chr20:33292090 TP53INP2 0.42 6.06 0.31 3.62e-9 Height; LUSC cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg01849466 chr14:104193079 ZFYVE21 -0.56 -8.86 -0.44 4.74e-17 Schizophrenia; LUSC cis rs3820068 0.603 rs1980607 chr1:15975237 A/G cg17385448 chr1:15911702 AGMAT 0.37 6.33 0.33 8.03e-10 Systolic blood pressure; LUSC cis rs34172651 0.917 rs11640931 chr16:24797919 A/G cg00339695 chr16:24857497 SLC5A11 0.36 6.28 0.33 1.03e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg26314531 chr2:26401878 FAM59B -0.71 -9.41 -0.46 8.43e-19 Gut microbiome composition (summer); LUSC trans rs61931739 0.817 rs7963318 chr12:34244929 C/G cg24313572 chr1:56050060 NA 0.32 6.8 0.35 4.94e-11 Morning vs. evening chronotype; LUSC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg12963246 chr6:28129442 ZNF389 0.4 6.4 0.33 5.12e-10 Parkinson's disease; LUSC cis rs9633740 0.685 rs10749608 chr10:82243986 A/G cg01528321 chr10:82214614 TSPAN14 1.0 6.98 0.36 1.58e-11 Post bronchodilator FEV1; LUSC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.41 -0.33 4.89e-10 Menopause (age at onset); LUSC cis rs12421382 0.811 rs11602639 chr11:109472829 C/T cg16359550 chr11:109292809 C11orf87 0.37 6.19 0.32 1.77e-9 Schizophrenia; LUSC cis rs1775715 0.737 rs1419171 chr10:32214831 C/A cg18675610 chr10:32216311 ARHGAP12 0.3 6.48 0.33 3.23e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg16680214 chr1:154839983 KCNN3 0.56 10.98 0.52 3.71e-24 Prostate cancer; LUSC cis rs6815814 0.950 rs11725779 chr4:38811668 G/A cg02016764 chr4:38805732 TLR1 -0.54 -5.74 -0.3 2.17e-8 Breast cancer; LUSC cis rs7759001 0.857 rs7754411 chr6:27359584 A/T cg18711553 chr6:27366782 ZNF391 -0.39 -5.74 -0.3 2.07e-8 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg23711669 chr6:146136114 FBXO30 -0.73 -12.91 -0.58 3.2e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg26028573 chr6:26043587 HIST1H2BB 0.39 5.74 0.3 2.08e-8 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.44 5.92 0.31 8.01e-9 Renal function-related traits (BUN); LUSC cis rs36405 0.500 rs2013781 chr14:72357320 T/C cg23396177 chr14:72358413 NA -0.38 -7.01 -0.36 1.32e-11 Yang-deficiency constitution; LUSC cis rs9467773 1.000 rs9986382 chr6:26550619 T/C cg05738196 chr6:26577821 NA 0.83 16.12 0.66 1.2e-43 Intelligence (multi-trait analysis); LUSC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.39 -6.46 -0.33 3.61e-10 Intelligence (multi-trait analysis); LUSC cis rs806215 0.901 rs989100 chr7:127220918 T/C cg25922125 chr7:127225783 GCC1 -0.61 -7.4 -0.38 1.12e-12 Type 2 diabetes; LUSC cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg18129178 chr5:148520854 ABLIM3 -0.7 -10.64 -0.5 5.82e-23 Breast cancer; LUSC cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs7394190 0.748 rs2292307 chr10:75549916 C/A cg07699608 chr10:75541558 CHCHD1 0.5 5.68 0.3 2.93e-8 Incident atrial fibrillation; LUSC trans rs561341 0.941 rs501773 chr17:30314435 T/G cg27661571 chr11:113659931 NA -0.6 -7.25 -0.37 2.83e-12 Hip circumference adjusted for BMI; LUSC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg19774624 chr17:42201019 HDAC5 0.71 10.36 0.49 5.25e-22 Total body bone mineral density; LUSC cis rs7829975 0.711 rs4481596 chr8:8704330 G/C cg18904891 chr8:8559673 CLDN23 0.41 6.27 0.32 1.09e-9 Mood instability; LUSC cis rs752010 0.714 rs6664708 chr1:42083070 G/A cg06885757 chr1:42089581 HIVEP3 0.48 10.18 0.49 2.2e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs6545883 0.929 rs7563678 chr2:61741811 C/T cg15711740 chr2:61764176 XPO1 0.51 8.12 0.41 8.95e-15 Tuberculosis; LUSC cis rs1003719 0.788 rs4817845 chr21:38447132 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.28 0.53 3.17e-25 Eye color traits; LUSC cis rs8078723 0.966 rs2227322 chr17:38171668 C/G cg17467752 chr17:38218738 THRA 0.78 12.57 0.57 5.92e-30 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs909341 0.909 rs2257885 chr20:62334220 G/A cg09650180 chr20:62225654 GMEB2 -0.46 -6.0 -0.31 5.12e-9 Atopic dermatitis; LUSC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg12927641 chr6:109611667 NA -0.35 -6.0 -0.31 5.23e-9 Reticulocyte fraction of red cells; LUSC cis rs7605827 0.930 rs7606850 chr2:15678250 T/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs11191270 0.554 rs11191253 chr10:104066507 A/T cg15320455 chr10:103880129 LDB1 0.58 5.9 0.31 8.78e-9 Intelligence (multi-trait analysis); LUSC cis rs1595825 0.891 rs16866940 chr2:198509058 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis; LUSC trans rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05039488 chr6:79577232 IRAK1BP1 0.65 10.31 0.49 7.85e-22 Endometrial cancer; LUSC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.16 -0.36 5.25e-12 Blood metabolite levels; LUSC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg03929089 chr4:120376271 NA 0.94 15.17 0.64 6.76e-40 Coronary artery disease; LUSC cis rs7107174 1.000 rs10899468 chr11:78016650 C/T cg02023728 chr11:77925099 USP35 0.49 6.88 0.35 3.02e-11 Testicular germ cell tumor; LUSC cis rs9914988 0.943 rs4795465 chr17:27151498 A/G cg09479241 chr17:27052676 TLCD1 -0.42 -5.92 -0.31 8.13e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2439831 0.867 rs2255051 chr15:43846161 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.85 9.51 0.46 3.89e-19 Lung cancer in ever smokers; LUSC cis rs11112613 0.713 rs55646142 chr12:105949557 G/A cg03607813 chr12:105948248 NA 0.82 12.44 0.56 1.96e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.48 -0.33 3.34e-10 Lung cancer; LUSC cis rs7617773 0.963 rs9822496 chr3:48181333 T/C cg20734569 chr3:48348370 SPINK8 -0.43 -7.73 -0.39 1.24e-13 Coronary artery disease; LUSC cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg15445000 chr17:37608096 MED1 0.4 6.86 0.35 3.35e-11 Glomerular filtration rate (creatinine); LUSC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg24060327 chr5:131705240 SLC22A5 -0.52 -8.76 -0.43 1.03e-16 Breast cancer; LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg10729496 chr3:10149963 C3orf24 0.53 7.11 0.36 7.27e-12 Alzheimer's disease; LUSC cis rs10207060 1.000 rs10207060 chr2:240687289 A/C cg20333904 chr2:240724165 NA -0.4 -7.3 -0.37 2.1e-12 Obesity-related traits; LUSC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22307029 chr19:49891270 CCDC155 0.67 9.41 0.46 8.02e-19 Multiple sclerosis; LUSC cis rs1882538 0.569 rs11562036 chr7:133076862 T/C cg10665199 chr7:133106180 EXOC4 0.58 8.08 0.4 1.19e-14 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17465697 chr1:228594029 TRIM11 -0.58 -7.42 -0.38 1.01e-12 Bipolar disorder and schizophrenia; LUSC cis rs9300255 0.507 rs1615350 chr12:123650335 C/T cg05973401 chr12:123451056 ABCB9 0.54 7.31 0.37 1.97e-12 Neutrophil percentage of white cells; LUSC cis rs721399 0.568 rs13254811 chr8:18273018 A/G cg18736775 chr8:18248649 NAT2 -0.55 -6.5 -0.33 3.01e-10 Blood metabolite levels; LUSC cis rs826838 1.000 rs860400 chr12:39081279 A/G cg26384229 chr12:38710491 ALG10B -0.83 -15.5 -0.65 3.41e-41 Heart rate; LUSC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.5 6.65 0.34 1.2e-10 Multiple sclerosis; LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg02951883 chr7:2050386 MAD1L1 -0.52 -9.11 -0.45 7.68e-18 Bipolar disorder and schizophrenia; LUSC cis rs981844 0.826 rs1545604 chr4:154682733 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.69 0.34 9.33e-11 Response to statins (LDL cholesterol change); LUSC cis rs4343996 0.626 rs57952815 chr7:3395417 T/A cg21248987 chr7:3385318 SDK1 -0.37 -6.28 -0.33 1.02e-9 Motion sickness; LUSC cis rs4474465 0.646 rs10793337 chr11:78285875 A/T cg27205649 chr11:78285834 NARS2 0.6 7.51 0.38 5.4e-13 Alzheimer's disease (survival time); LUSC cis rs6494488 0.500 rs59684202 chr15:65018501 A/C cg08069370 chr15:64387884 SNX1 -0.61 -5.8 -0.3 1.52e-8 Coronary artery disease; LUSC cis rs2204008 0.560 rs4129033 chr12:38301897 A/T cg26384229 chr12:38710491 ALG10B -0.57 -8.5 -0.42 6.28e-16 Bladder cancer; LUSC cis rs66887589 0.616 rs6822808 chr4:120217365 C/A cg13609457 chr4:120235615 NA 0.4 6.15 0.32 2.27e-9 Diastolic blood pressure; LUSC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg06212747 chr3:49208901 KLHDC8B 0.42 5.81 0.3 1.43e-8 Parkinson's disease; LUSC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg26897989 chr16:1907736 C16orf73 -0.44 -6.36 -0.33 6.63e-10 Glomerular filtration rate in chronic kidney disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg07068942 chr3:156806752 NA 0.4 6.0 0.31 5.1e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs1801251 0.896 rs2305141 chr2:233684402 A/G cg25237894 chr2:233734115 C2orf82 -0.33 -6.05 -0.31 3.82e-9 Coronary artery disease; LUSC cis rs929596 0.793 rs2602376 chr2:234582051 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.5 -7.0 -0.36 1.4e-11 Total bilirubin levels in HIV-1 infection; LUSC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11890956 chr21:40555474 PSMG1 -0.74 -11.95 -0.55 1.2e-27 Cognitive function; LUSC cis rs4594175 0.962 rs7157823 chr14:51633170 C/T cg23942311 chr14:51606299 NA 0.3 5.68 0.3 2.86e-8 Cancer; LUSC trans rs17685 0.625 rs1639630 chr7:75730499 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.78e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg18404041 chr3:52824283 ITIH1 -0.58 -11.28 -0.53 3.1e-25 Bipolar disorder; LUSC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg05585544 chr11:47624801 NA -0.42 -7.37 -0.37 1.35e-12 Subjective well-being; LUSC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg23630131 chr7:65973040 NA -0.2 -5.73 -0.3 2.23e-8 Aortic root size; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.71 12.02 0.55 6.57e-28 Prudent dietary pattern; LUSC cis rs34734847 0.703 rs3794215 chr12:121168083 T/C cg27246729 chr12:121163418 ACADS 0.42 6.63 0.34 1.38e-10 Mean corpuscular volume; LUSC cis rs243505 1.000 rs243520 chr7:148423560 C/T cg09806900 chr7:148480153 CUL1 -0.49 -6.87 -0.35 3.09e-11 Inflammatory bowel disease;Crohn's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12423338 chr3:99944194 NA -0.77 -6.04 -0.31 4.11e-9 Cognitive performance; LUSC cis rs2303282 0.716 rs7192780 chr16:56467566 A/G cg00500540 chr16:56394104 NA -0.43 -7.38 -0.37 1.27e-12 Breast cancer; LUSC cis rs9640161 0.658 rs74348353 chr7:150053655 C/A cg17279839 chr7:150038598 RARRES2 0.43 6.62 0.34 1.44e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg02018176 chr4:1364513 KIAA1530 0.55 9.75 0.47 6.39e-20 Longevity; LUSC cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg26924012 chr15:45694286 SPATA5L1 1.12 19.83 0.74 2.12e-58 Homoarginine levels; LUSC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg16049864 chr8:95962084 TP53INP1 -0.68 -13.49 -0.59 2e-33 Type 2 diabetes; LUSC trans rs7980799 0.682 rs1601007 chr12:33609675 C/G cg26384229 chr12:38710491 ALG10B 0.59 8.76 0.43 9.93e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs12476592 1.000 rs12476592 chr2:63850098 G/C cg10828910 chr2:63850056 LOC388955 -0.55 -6.1 -0.32 3e-9 Childhood ear infection; LUSC cis rs2273669 0.588 rs78276890 chr6:109305299 G/A cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.86 -0.4 5.34e-14 Blood metabolite levels; LUSC cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg11584989 chr19:19387371 SF4 0.58 7.02 0.36 1.22e-11 Bipolar disorder; LUSC cis rs12579753 0.879 rs10778828 chr12:82117216 C/A cg21231944 chr12:82153410 PPFIA2 -0.38 -5.85 -0.31 1.15e-8 Resting heart rate; LUSC cis rs12681287 0.640 rs13267782 chr8:87481887 G/T cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.31e-12 Caudate activity during reward; LUSC cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.78 -0.3 1.71e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg22800045 chr5:56110881 MAP3K1 0.46 6.12 0.32 2.65e-9 Coronary artery disease; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg06145435 chr7:1022769 CYP2W1 0.33 6.86 0.35 3.28e-11 Longevity;Endometriosis; LUSC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg23711669 chr6:146136114 FBXO30 0.88 16.13 0.66 1.12e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs2970818 0.764 rs11063182 chr12:4581371 A/G cg11146114 chr12:4671731 NA -0.58 -6.0 -0.31 5.05e-9 Phosphorus levels; LUSC cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg19789473 chr17:27170043 C17orf63 -0.31 -5.83 -0.3 1.34e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9398803 0.865 rs9398810 chr6:126815604 C/A cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.94e-9 Male-pattern baldness; LUSC trans rs7824557 0.527 rs2572446 chr8:11239565 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.85 -0.35 3.67e-11 Retinal vascular caliber; LUSC cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg13319975 chr6:146136371 FBXO30 -0.41 -6.01 -0.31 4.79e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs11209002 1.000 rs3762320 chr1:67588647 T/G cg02640540 chr1:67518911 SLC35D1 0.64 7.05 0.36 1.05e-11 Crohn's disease; LUSC cis rs2573652 1.000 rs2581365 chr15:100513318 A/C cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.36 -0.37 1.48e-12 Height; LUSC cis rs6087990 0.735 rs6058891 chr20:31386347 T/C cg13636640 chr20:31349939 DNMT3B 0.91 18.58 0.71 2.11e-53 Ulcerative colitis; LUSC cis rs8062405 0.755 rs17707300 chr16:28593347 A/G cg16576597 chr16:28551801 NUPR1 0.3 6.06 0.31 3.74e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg22903657 chr4:1355424 KIAA1530 -0.48 -8.01 -0.4 1.94e-14 Obesity-related traits; LUSC cis rs7572733 0.534 rs700674 chr2:198693703 C/T cg00792783 chr2:198669748 PLCL1 0.43 5.7 0.3 2.66e-8 Dermatomyositis; LUSC cis rs1403694 0.515 rs710448 chr3:186452885 A/G cg12454167 chr3:186435060 KNG1 0.29 7.56 0.38 3.97e-13 Blood protein levels; LUSC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg18827107 chr12:86230957 RASSF9 -0.49 -7.15 -0.36 5.47e-12 Major depressive disorder; LUSC cis rs7091068 0.616 rs7901507 chr10:95505424 C/G cg20715218 chr10:95462985 C10orf4 0.59 6.48 0.33 3.2e-10 Urinary tract infection frequency; LUSC trans rs11782517 0.889 rs56730365 chr8:10109379 G/T cg15556689 chr8:8085844 FLJ10661 0.48 6.05 0.31 3.83e-9 Nose size; LUSC cis rs1878931 0.580 rs4785932 chr16:3410456 C/G cg00484396 chr16:3507460 NAT15 -0.39 -6.52 -0.34 2.54e-10 Body mass index (adult); LUSC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg07636037 chr3:49044803 WDR6 -0.67 -8.82 -0.43 6.53e-17 Menarche (age at onset); LUSC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.52 -7.63 -0.39 2.53e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg27129171 chr3:47204927 SETD2 0.58 8.26 0.41 3.51e-15 Birth weight; LUSC cis rs1729951 0.546 rs12054408 chr3:136677645 T/C cg12473912 chr3:136751656 NA 0.39 6.74 0.35 6.82e-11 Neuroticism; LUSC cis rs500891 0.574 rs12203860 chr6:84174401 C/T cg08257003 chr6:84140564 ME1 -0.31 -7.15 -0.36 5.58e-12 Platelet-derived growth factor BB levels; LUSC cis rs8062405 0.756 rs151182 chr16:28495752 C/T cg16576597 chr16:28551801 NUPR1 0.28 5.7 0.3 2.69e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11030122 0.702 rs10835312 chr11:3950253 G/A cg18678763 chr11:4115507 RRM1 -0.45 -5.82 -0.3 1.38e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs9650315 0.733 rs56127704 chr8:57206231 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs1448094 0.717 rs7137122 chr12:86290702 T/C cg25456477 chr12:86230367 RASSF9 0.39 6.84 0.35 3.72e-11 Major depressive disorder; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg08088566 chr11:430123 ANO9 0.64 7.47 0.38 7.09e-13 Body mass index; LUSC trans rs7824557 0.564 rs2736288 chr8:11228100 G/A cg08975724 chr8:8085496 FLJ10661 -0.5 -7.28 -0.37 2.44e-12 Retinal vascular caliber; LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg22920501 chr2:26401640 FAM59B -0.79 -11.86 -0.54 2.53e-27 Gut microbiome composition (summer); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg25560363 chr15:77925481 LINGO1 0.46 6.17 0.32 1.99e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs240764 0.853 rs12191199 chr6:101008093 C/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.48 -0.33 3.35e-10 Neuroticism; LUSC cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg16099169 chr2:106886729 NA 0.5 6.4 0.33 5.32e-10 Facial morphology (factor 23); LUSC trans rs4332037 0.906 rs62442903 chr7:1953416 G/A cg25206134 chr2:45395956 NA 0.53 6.3 0.33 9.55e-10 Bipolar disorder; LUSC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg27432699 chr2:27873401 GPN1 -0.57 -8.44 -0.42 9.56e-16 Total body bone mineral density; LUSC cis rs7824557 0.628 rs7008205 chr8:11197323 T/G cg21293242 chr8:11204541 TDH 0.31 5.75 0.3 2.04e-8 Retinal vascular caliber; LUSC cis rs6495367 1.000 rs13380109 chr15:79378775 G/A cg17916960 chr15:79447300 NA 0.35 6.73 0.35 7.48e-11 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2282300 0.739 rs34855782 chr11:30225470 G/A cg25418670 chr11:30344373 C11orf46 -0.61 -8.81 -0.43 7.19e-17 Morning vs. evening chronotype; LUSC cis rs950776 0.593 rs601079 chr15:78869579 T/A cg22563815 chr15:78856949 CHRNA5 -0.25 -6.09 -0.32 3.11e-9 Sudden cardiac arrest; LUSC cis rs2282802 0.685 rs2116790 chr5:139654115 G/A cg26211634 chr5:139558579 C5orf32 0.44 8.14 0.41 8.05e-15 Intelligence (multi-trait analysis); LUSC trans rs8073060 0.586 rs2428464 chr17:34021994 C/G cg19694781 chr19:47549865 TMEM160 -1.13 -17.99 -0.7 4.71e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2816062 0.786 rs2745316 chr1:18896830 G/A cg18795169 chr1:18902165 NA -1.01 -24.32 -0.8 6.36e-76 Urate levels in lean individuals; LUSC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg12963246 chr6:28129442 ZNF389 0.4 6.22 0.32 1.53e-9 Parkinson's disease; LUSC cis rs72781680 0.898 rs72796396 chr2:24178154 G/A cg08917208 chr2:24149416 ATAD2B 0.91 10.18 0.49 2.2e-21 Lymphocyte counts; LUSC cis rs57994353 0.568 rs10870166 chr9:139316916 C/G cg14019695 chr9:139328340 INPP5E 0.36 5.65 0.3 3.42e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; LUSC cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg05738196 chr6:26577821 NA 0.54 6.4 0.33 5.3e-10 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.62e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg13647721 chr17:30228624 UTP6 -0.65 -6.38 -0.33 5.81e-10 Hip circumference adjusted for BMI; LUSC cis rs2439831 0.850 rs28684672 chr15:44107662 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.68 0.34 9.91e-11 Lung cancer in ever smokers; LUSC cis rs10751667 0.600 rs11246376 chr11:999622 C/T ch.11.42038R chr11:967971 AP2A2 0.47 6.99 0.36 1.49e-11 Alzheimer's disease (late onset); LUSC cis rs983392 0.667 rs583791 chr11:59947252 C/T cg20284999 chr11:59952153 MS4A6A 0.36 6.24 0.32 1.3e-9 Alzheimer's disease (late onset); LUSC cis rs4268898 0.636 rs9636438 chr2:24460566 C/T cg06627628 chr2:24431161 ITSN2 0.86 12.53 0.57 8.99e-30 Asthma; LUSC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg09085632 chr11:111637200 PPP2R1B -1.03 -15.49 -0.65 3.76e-41 Primary sclerosing cholangitis; LUSC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg20243544 chr17:37824526 PNMT 0.52 7.41 0.38 1.02e-12 Asthma; LUSC cis rs11098499 0.954 rs2389803 chr4:120393511 A/G cg24375607 chr4:120327624 NA -0.77 -11.53 -0.53 4.12e-26 Corneal astigmatism; LUSC cis rs921968 0.509 rs655441 chr2:219357545 C/T cg02176678 chr2:219576539 TTLL4 0.73 14.19 0.61 4.47e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs3808502 0.549 rs1382563 chr8:11426790 C/G cg21175976 chr8:11421337 BLK 0.34 5.81 0.3 1.44e-8 Neuroticism; LUSC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg25204440 chr1:209979598 IRF6 0.5 5.72 0.3 2.36e-8 Cleft lip with or without cleft palate; LUSC cis rs60154123 0.614 rs127043 chr1:210459011 T/G cg22029157 chr1:209979665 IRF6 0.5 5.88 0.31 9.75e-9 Coronary artery disease; LUSC cis rs854765 0.624 rs12952723 chr17:17731651 T/C cg04398451 chr17:18023971 MYO15A 0.4 6.24 0.32 1.36e-9 Total body bone mineral density; LUSC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg09655341 chr17:79618100 PDE6G 0.27 6.31 0.33 9.05e-10 Eye color traits; LUSC cis rs6545883 0.718 rs6715259 chr2:61851845 G/T cg15711740 chr2:61764176 XPO1 -0.37 -5.85 -0.3 1.17e-8 Tuberculosis; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg22535103 chr8:58192502 C8orf71 -0.79 -8.37 -0.42 1.55e-15 Developmental language disorder (linguistic errors); LUSC trans rs7980799 0.649 rs2220059 chr12:33648630 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.92 -0.4 3.67e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs7939886 0.764 rs12282595 chr11:55933084 C/T cg15704280 chr7:45808275 SEPT13 0.8 6.14 0.32 2.3e-9 Myopia (pathological); LUSC cis rs2011503 0.882 rs8108777 chr19:19359058 C/A cg11244672 chr19:19639970 YJEFN3 -0.54 -6.56 -0.34 1.99e-10 Bipolar disorder; LUSC cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg26384229 chr12:38710491 ALG10B 0.88 15.03 0.64 2.4e-39 Bladder cancer; LUSC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg14019146 chr3:50243930 SLC38A3 -0.29 -6.31 -0.33 8.76e-10 Intelligence (multi-trait analysis); LUSC cis rs926938 0.527 rs360583 chr1:115462743 C/T cg12756093 chr1:115239321 AMPD1 0.46 7.0 0.36 1.43e-11 Autism; LUSC cis rs9457247 0.602 rs12208359 chr6:167458455 G/A cg06454157 chr6:167490870 NA -0.3 -6.94 -0.36 2.04e-11 Crohn's disease; LUSC cis rs1163251 0.756 rs539799 chr1:120208472 C/T cg19096424 chr1:120255104 PHGDH 0.43 6.01 0.31 4.78e-9 Blood metabolite levels; LUSC cis rs9910055 0.550 rs850856 chr17:42157739 C/T cg19774624 chr17:42201019 HDAC5 0.71 9.79 0.47 4.52e-20 Total body bone mineral density; LUSC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -7.03 -0.36 1.2e-11 Total body bone mineral density; LUSC cis rs9527 0.615 rs7089065 chr10:104723022 C/T cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.46 1.42e-18 Arsenic metabolism; LUSC cis rs1499972 0.941 rs7631320 chr3:117650116 T/C cg07612923 chr3:117604196 NA 0.65 5.87 0.31 1.03e-8 Schizophrenia; LUSC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.03e-34 Prostate cancer; LUSC cis rs7131987 0.845 rs2042511 chr12:29408780 C/T cg09582351 chr12:29534625 ERGIC2 -0.32 -6.62 -0.34 1.39e-10 QT interval; LUSC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg03036452 chr22:46663545 TTC38 0.54 5.82 0.3 1.41e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs859767 0.519 rs11688414 chr2:135420237 G/A cg12500956 chr2:135428796 TMEM163 -0.26 -6.02 -0.31 4.55e-9 Neuroticism; LUSC cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg22618164 chr12:122356400 WDR66 0.63 9.34 0.46 1.38e-18 Mean corpuscular volume; LUSC cis rs713587 0.646 rs2384061 chr2:25135620 C/T cg04586622 chr2:25135609 ADCY3 0.41 8.92 0.44 3.12e-17 Body mass index in non-asthmatics; LUSC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg22638593 chr5:131593259 PDLIM4 0.43 5.67 0.3 3.15e-8 Breast cancer; LUSC cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg13736514 chr6:26305472 NA -0.46 -9.26 -0.45 2.64e-18 Educational attainment; LUSC cis rs1550582 0.547 rs6991998 chr8:135580221 C/A cg17885191 chr8:135476712 NA 0.58 7.49 0.38 6.04e-13 Educational attainment; LUSC cis rs11864453 0.614 rs12445586 chr16:72126276 C/T cg01557791 chr16:72042693 DHODH -0.52 -7.54 -0.38 4.61e-13 Fibrinogen levels; LUSC cis rs926938 0.618 rs1286560 chr1:115375930 C/T cg12756093 chr1:115239321 AMPD1 -0.53 -8.04 -0.4 1.59e-14 Autism; LUSC cis rs7577851 0.716 rs55932708 chr2:69679197 G/A cg10773587 chr2:69614142 GFPT1 0.55 6.23 0.32 1.39e-9 Parkinson's disease (age of onset); LUSC cis rs921665 0.748 rs1869420 chr2:3202073 C/T cg02624386 chr2:3182749 NA 0.62 6.61 0.34 1.55e-10 World class endurance athleticism; LUSC cis rs7705502 1.000 rs75738222 chr5:173349404 C/T cg18693985 chr5:173351052 CPEB4 -0.36 -5.84 -0.3 1.23e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs8060686 0.545 rs78229587 chr16:68165243 T/C cg09835421 chr16:68378352 PRMT7 -0.59 -6.21 -0.32 1.59e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.7 0.34 8.88e-11 Personality dimensions; LUSC cis rs61931739 0.500 rs7955247 chr12:34126580 G/A cg06521331 chr12:34319734 NA -0.48 -7.88 -0.4 4.7e-14 Morning vs. evening chronotype; LUSC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg24733560 chr20:60626293 TAF4 0.41 6.65 0.34 1.17e-10 Body mass index; LUSC cis rs7954584 0.635 rs3847694 chr12:122325820 A/G cg01765077 chr12:122356316 WDR66 0.5 7.3 0.37 2.17e-12 Mean corpuscular volume; LUSC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg07256732 chr16:621771 PIGQ -0.35 -6.47 -0.33 3.58e-10 Height; LUSC cis rs9831754 1.000 rs9822043 chr3:78352113 T/C cg06138941 chr3:78371609 NA -0.77 -10.25 -0.49 1.29e-21 Calcium levels; LUSC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg19077165 chr18:44547161 KATNAL2 -0.42 -6.35 -0.33 7.14e-10 Personality dimensions; LUSC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg11965913 chr1:205819406 PM20D1 -0.45 -6.5 -0.34 2.84e-10 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg17971929 chr21:40555470 PSMG1 0.78 13.04 0.58 1.06e-31 Cognitive function; LUSC cis rs12530845 1.000 rs73721606 chr7:135335678 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs17095355 1.000 rs17095355 chr10:111735750 C/T cg00817464 chr10:111662876 XPNPEP1 -0.52 -6.78 -0.35 5.34e-11 Biliary atresia; LUSC trans rs7307780 0.703 rs12317066 chr12:76236777 C/T cg05238905 chr6:149867353 PPIL4 0.61 5.96 0.31 6.37e-9 Sudden cardiac arrest; LUSC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg00339695 chr16:24857497 SLC5A11 -0.62 -9.73 -0.47 7.05e-20 Intelligence (multi-trait analysis); LUSC cis rs7258465 0.965 rs271622 chr19:18629277 A/G cg06462663 chr19:18546047 ISYNA1 0.45 7.63 0.39 2.54e-13 Breast cancer; LUSC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg17173187 chr15:85201210 NMB 0.37 6.5 0.33 3e-10 Schizophrenia; LUSC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg13683864 chr3:40499215 RPL14 -1.11 -21.81 -0.77 3.53e-66 Renal cell carcinoma; LUSC cis rs2625529 0.824 rs12916951 chr15:72252498 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.66 -0.39 1.97e-13 Red blood cell count; LUSC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg06481639 chr22:41940642 POLR3H -0.53 -6.19 -0.32 1.77e-9 Vitiligo; LUSC cis rs870825 0.616 rs4256263 chr4:185622959 C/A cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC trans rs9929218 0.953 rs28608872 chr16:68802038 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.67 -0.54 1.26e-26 Colorectal cancer; LUSC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs2486288 0.656 rs1060896 chr15:45554267 C/A cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.67 -0.5 4.42e-23 Glomerular filtration rate; LUSC cis rs2425143 0.818 rs7272684 chr20:34424692 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -6.12 -0.32 2.58e-9 Blood protein levels; LUSC cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg13010199 chr12:38710504 ALG10B 0.68 11.27 0.52 3.61e-25 Heart rate; LUSC cis rs4805272 0.582 rs11083652 chr19:29231569 G/C cg12756686 chr19:29218302 NA -0.46 -7.05 -0.36 1.01e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9309473 0.687 rs6747145 chr2:73609177 C/T cg20560298 chr2:73613845 ALMS1 -0.61 -8.8 -0.43 7.42e-17 Metabolite levels; LUSC cis rs8099014 1.000 rs4464160 chr18:56111830 T/G cg12907477 chr18:56117327 MIR122 0.47 7.45 0.38 8.12e-13 Platelet count; LUSC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg19539972 chr4:7069911 GRPEL1 0.54 6.08 0.32 3.28e-9 Monocyte percentage of white cells; LUSC cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg13319975 chr6:146136371 FBXO30 -0.51 -7.62 -0.38 2.62e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05670192 chr19:56154902 ZNF581 0.4 6.02 0.31 4.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg21028142 chr17:79581711 NPLOC4 0.35 8.24 0.41 4.03e-15 Eye color traits; LUSC cis rs1348850 0.914 rs4893961 chr2:178411075 A/G cg22681709 chr2:178499509 PDE11A -0.51 -9.39 -0.46 9.87e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg06287003 chr12:125626642 AACS 0.4 7.32 0.37 1.89e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg07701084 chr6:150067640 NUP43 0.56 8.39 0.42 1.36e-15 Lung cancer; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.29 -7.43 -0.38 9.19e-13 Lymphocyte counts; LUSC cis rs4704187 0.687 rs10462354 chr5:74453027 T/G cg03227963 chr5:74354835 NA 0.31 6.8 0.35 4.74e-11 Response to amphetamines; LUSC cis rs2708977 1.000 rs1011040 chr2:97212755 A/G cg01950434 chr2:97203154 ARID5A -0.53 -7.99 -0.4 2.28e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs28735056 0.904 rs11665111 chr18:77622996 T/C cg20368463 chr18:77673604 PQLC1 0.48 6.78 0.35 5.39e-11 Schizophrenia; LUSC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs1979679 0.608 rs1581075 chr12:28723925 T/A cg13890972 chr12:28721907 NA -0.42 -6.0 -0.31 5.21e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg00343986 chr7:65444356 GUSB 0.45 6.92 0.35 2.33e-11 Aortic root size; LUSC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.23 0.37 3.41e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9393777 0.623 rs7756567 chr6:26481642 T/G cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC cis rs6977660 0.714 rs10228783 chr7:19789290 C/T cg07541023 chr7:19748670 TWISTNB 0.68 7.31 0.37 1.98e-12 Thyroid stimulating hormone; LUSC cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg05283184 chr6:79620031 NA -0.57 -11.86 -0.54 2.54e-27 Intelligence (multi-trait analysis); LUSC cis rs2282032 1.000 rs2282032 chr14:90758891 G/T cg14092571 chr14:90743983 NA 0.5 6.69 0.34 9.33e-11 Longevity; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02054479 chr16:20911997 LYRM1;DCUN1D3 0.39 6.32 0.33 8.6e-10 Triglycerides; LUSC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg11366901 chr6:160182831 ACAT2 0.91 12.34 0.56 4.35e-29 Age-related macular degeneration (geographic atrophy); LUSC cis rs6681460 1.000 rs7532173 chr1:67086111 A/G cg02459107 chr1:67143332 SGIP1 0.47 8.58 0.42 3.63e-16 Presence of antiphospholipid antibodies; LUSC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg12379764 chr21:47803548 PCNT -0.49 -6.88 -0.35 2.96e-11 Testicular germ cell tumor; LUSC cis rs72781680 0.898 rs72786288 chr2:24075416 G/T cg20701182 chr2:24300061 SF3B14 0.54 5.78 0.3 1.73e-8 Lymphocyte counts; LUSC cis rs9549260 0.785 rs10507484 chr13:41218134 T/C cg21288729 chr13:41239152 FOXO1 0.64 10.0 0.48 9.34e-21 Red blood cell count; LUSC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.07 16.17 0.66 7.65e-44 Age-related macular degeneration (geographic atrophy); LUSC cis rs1728785 0.892 rs1617749 chr16:68580890 A/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.73 -0.3 2.23e-8 Ulcerative colitis; LUSC cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC trans rs9951602 0.512 rs8084836 chr18:76647841 A/G cg02800362 chr5:177631904 HNRNPAB 0.86 12.77 0.57 1.08e-30 Obesity-related traits; LUSC trans rs2188420 0.745 rs711440 chr7:106587964 T/C cg04262465 chr14:101405693 SNORD113-6 -0.4 -6.11 -0.32 2.75e-9 Interferon gamma levels; LUSC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg23283495 chr1:209979779 IRF6 0.69 9.03 0.44 1.43e-17 Cleft lip with or without cleft palate; LUSC cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.97 13.83 0.6 1.05e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs67460515 0.563 rs1599375 chr3:160897771 C/T cg03342759 chr3:160939853 NMD3 0.44 6.26 0.32 1.15e-9 Parkinson's disease; LUSC cis rs9300255 0.602 rs1716167 chr12:123651162 C/T cg00376283 chr12:123451042 ABCB9 -0.65 -8.27 -0.41 3.33e-15 Neutrophil percentage of white cells; LUSC trans rs9650657 0.513 rs7005884 chr8:10796472 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.56 -0.38 3.89e-13 Neuroticism; LUSC cis rs17539620 0.624 rs74551216 chr6:154840524 T/C cg20019720 chr6:154832845 CNKSR3 0.62 8.53 0.42 5.16e-16 Lipoprotein (a) levels; LUSC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg00933542 chr6:150070202 PCMT1 -0.3 -6.2 -0.32 1.62e-9 Lung cancer; LUSC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg23958373 chr8:599963 NA -0.68 -6.17 -0.32 1.92e-9 IgG glycosylation; LUSC cis rs12956009 0.518 rs1434518 chr18:44833498 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.55 0.34 2.11e-10 Educational attainment (years of education); LUSC cis rs7224314 1.000 rs62084077 chr17:65386837 G/A cg01507342 chr17:65387096 PITPNC1 -0.45 -7.94 -0.4 3.06e-14 Diisocyanate-induced asthma; LUSC cis rs7769051 0.522 rs9493449 chr6:133126179 T/A cg22852734 chr6:133119734 C6orf192 1.33 10.41 0.49 3.74e-22 Type 2 diabetes nephropathy; LUSC cis rs8092503 1.000 rs12456067 chr18:52499448 C/T cg12377874 chr18:52495404 RAB27B 0.32 5.67 0.3 3.12e-8 Childhood body mass index; LUSC cis rs2230307 0.536 rs834277 chr1:100510855 T/G cg24955406 chr1:100503596 HIAT1 0.57 6.15 0.32 2.23e-9 Carotid intima media thickness; LUSC trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg11887960 chr12:57824829 NA 0.56 6.84 0.35 3.75e-11 Lung disease severity in cystic fibrosis; LUSC cis rs9916302 0.706 rs2338799 chr17:37513941 G/A cg07936489 chr17:37558343 FBXL20 0.8 9.91 0.48 1.86e-20 Glomerular filtration rate (creatinine); LUSC cis rs12681288 0.550 rs73176529 chr8:962283 G/C cg04851639 chr8:1020857 NA -0.4 -8.05 -0.4 1.45e-14 Schizophrenia; LUSC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg11764359 chr7:65958608 NA -0.62 -9.33 -0.45 1.47e-18 Calcium levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09700990 chr6:90122154 RRAGD 0.53 7.44 0.38 8.82e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4729127 1.000 rs78697521 chr7:94012938 G/C cg14660007 chr13:78271894 SLAIN1 0.5 5.97 0.31 5.96e-9 Intelligence; LUSC cis rs9788682 0.748 rs2456020 chr15:78868398 C/T cg24631222 chr15:78858424 CHRNA5 0.68 9.05 0.44 1.19e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg13206674 chr6:150067644 NUP43 0.6 9.26 0.45 2.6e-18 Lung cancer; LUSC cis rs6500395 0.735 rs16946340 chr16:48667717 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.34 0.33 7.38e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg17294928 chr15:75287854 SCAMP5 -0.76 -10.13 -0.48 3.23e-21 Blood trace element (Zn levels); LUSC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg04546413 chr19:29218101 NA 0.72 11.5 0.53 5.38e-26 Methadone dose in opioid dependence; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs5769707 0.681 rs135879 chr22:50018651 C/T cg10356904 chr22:49881777 NA -0.3 -6.19 -0.32 1.74e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg06453172 chr10:134556979 INPP5A -0.49 -6.11 -0.32 2.78e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg18765753 chr7:1198926 ZFAND2A -0.36 -6.25 -0.32 1.27e-9 Longevity;Endometriosis; LUSC cis rs6987853 0.736 rs35295075 chr8:42428852 A/G cg09913449 chr8:42400586 C8orf40 0.53 9.15 0.45 5.62e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg13798780 chr7:105162888 PUS7 0.53 5.96 0.31 6.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg07507251 chr3:52567010 NT5DC2 0.31 6.02 0.31 4.57e-9 Bipolar disorder; LUSC cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg11189052 chr15:85197271 WDR73 0.5 6.45 0.33 3.81e-10 Schizophrenia; LUSC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg22907277 chr7:1156413 C7orf50 0.7 8.15 0.41 7.16e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg23630131 chr7:65973040 NA -0.22 -6.03 -0.31 4.39e-9 Aortic root size; LUSC cis rs7582180 0.629 rs12617779 chr2:100937707 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis); LUSC cis rs3125734 0.653 rs1007976 chr10:63970144 C/T cg09941381 chr10:64027924 RTKN2 0.33 6.16 0.32 2.12e-9 Rheumatoid arthritis; LUSC cis rs6940638 0.688 rs6921388 chr6:27080205 A/G cg12826209 chr6:26865740 GUSBL1 0.54 7.83 0.39 6.36e-14 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13126279 chr21:47581558 C21orf56 -0.54 -8.14 -0.41 8.18e-15 Testicular germ cell tumor; LUSC cis rs727505 0.551 rs2293346 chr7:124783849 C/T cg23710748 chr7:124431027 NA -0.38 -6.65 -0.34 1.22e-10 Lewy body disease; LUSC cis rs9796 0.553 rs2925343 chr15:41306493 T/C cg18705301 chr15:41695430 NDUFAF1 0.58 10.38 0.49 4.7e-22 Menopause (age at onset); LUSC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.0 -0.31 5.07e-9 Major depressive disorder; LUSC cis rs1595825 0.891 rs7587716 chr2:198630667 G/T cg00982548 chr2:198649783 BOLL -0.58 -7.21 -0.37 3.87e-12 Ulcerative colitis; LUSC cis rs62400317 0.859 rs12191566 chr6:45160002 T/C cg20913747 chr6:44695427 NA -0.48 -7.67 -0.39 1.91e-13 Total body bone mineral density; LUSC cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC trans rs4332037 0.906 rs62442903 chr7:1953416 G/A cg11693508 chr17:37793320 STARD3 0.59 7.39 0.37 1.21e-12 Bipolar disorder; LUSC cis rs9837602 0.882 rs9875664 chr3:99729130 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.96 -0.31 6.33e-9 Breast cancer; LUSC cis rs921665 0.831 rs7578217 chr2:3175376 A/G cg16434511 chr2:3151078 NA 0.52 5.85 0.3 1.18e-8 World class endurance athleticism; LUSC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg17330251 chr7:94953956 PON1 -0.37 -6.0 -0.31 5.2e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg05294307 chr14:35346193 BAZ1A -0.62 -7.46 -0.38 7.55e-13 Psoriasis; LUSC trans rs9951602 0.512 rs12607938 chr18:76651887 A/C cg02800362 chr5:177631904 HNRNPAB 0.88 13.23 0.59 1.97e-32 Obesity-related traits; LUSC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg04025307 chr7:1156635 C7orf50 0.44 6.09 0.32 3.11e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9304742 0.962 rs12461778 chr19:53454963 T/A cg09915433 chr19:53449742 NA -0.61 -9.67 -0.47 1.14e-19 Psoriasis; LUSC cis rs61931739 0.534 rs11053021 chr12:34111157 C/T cg06521331 chr12:34319734 NA -0.47 -7.66 -0.39 2.08e-13 Morning vs. evening chronotype; LUSC trans rs7395662 0.591 rs4882093 chr11:48530820 G/A cg15704280 chr7:45808275 SEPT13 -0.45 -6.23 -0.32 1.42e-9 HDL cholesterol; LUSC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg11812906 chr14:75593930 NEK9 -0.67 -11.46 -0.53 7.4e-26 Height; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19522332 chr3:178866004 PIK3CA 0.39 6.39 0.33 5.49e-10 Triglycerides; LUSC trans rs7824557 0.872 rs2572417 chr8:11111462 A/T cg08975724 chr8:8085496 FLJ10661 -0.41 -6.22 -0.32 1.51e-9 Retinal vascular caliber; LUSC cis rs9532580 0.553 rs9549250 chr13:41225229 T/G cg21288729 chr13:41239152 FOXO1 0.63 9.68 0.47 1.06e-19 Mean corpuscular hemoglobin; LUSC cis rs3820068 0.608 rs12091644 chr1:16044945 G/A cg17385448 chr1:15911702 AGMAT 0.37 5.89 0.31 9.18e-9 Systolic blood pressure; LUSC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg22166914 chr1:53195759 ZYG11B 0.68 11.27 0.53 3.38e-25 Monocyte count; LUSC cis rs4343996 0.967 rs10224769 chr7:3347166 A/T cg21248987 chr7:3385318 SDK1 0.4 6.68 0.34 1e-10 Motion sickness; LUSC cis rs854765 0.624 rs12952723 chr17:17731651 T/C cg16928487 chr17:17741425 SREBF1 0.47 9.21 0.45 3.57e-18 Total body bone mineral density; LUSC cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 7.69e-15 Axial length; LUSC cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg18512352 chr11:47633146 NA -0.47 -9.04 -0.44 1.27e-17 Subjective well-being; LUSC cis rs7119 0.717 rs35268067 chr15:77753688 C/G cg27398640 chr15:77910606 LINGO1 -0.29 -5.85 -0.3 1.17e-8 Type 2 diabetes; LUSC cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg14844989 chr11:31128820 NA -0.37 -5.77 -0.3 1.83e-8 Red blood cell count; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg10802521 chr3:52805072 NEK4 0.52 8.56 0.42 4.18e-16 Bipolar disorder; LUSC cis rs11864453 0.826 rs6499560 chr16:72147666 G/T cg01557791 chr16:72042693 DHODH 0.52 7.47 0.38 6.98e-13 Fibrinogen levels; LUSC cis rs41271473 0.526 rs12353961 chr1:228738252 G/C cg16512390 chr1:228756714 NA 0.7 8.78 0.43 8.79e-17 Chronic lymphocytic leukemia; LUSC cis rs117623576 0.941 rs60146023 chr10:32411515 G/A cg03047570 chr10:32398778 NA -0.61 -6.61 -0.34 1.49e-10 Anti-saccade response; LUSC cis rs559928 0.606 rs11231710 chr11:63925743 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 7.11 0.36 7.16e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg01368799 chr11:117014884 PAFAH1B2 0.49 6.71 0.34 8.43e-11 Blood protein levels; LUSC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs6977940 0.818 rs73033490 chr7:2909730 C/T cg19731401 chr7:2775893 GNA12 0.57 6.55 0.34 2.14e-10 White matter integrity; LUSC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg13798780 chr7:105162888 PUS7 0.56 5.91 0.31 8.51e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg05347473 chr6:146136440 FBXO30 0.49 8.24 0.41 4.05e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs7937682 0.924 rs489783 chr11:111520522 A/G cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg05738196 chr6:26577821 NA -0.55 -8.61 -0.43 2.88e-16 Schizophrenia; LUSC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC cis rs1847202 0.859 rs4490296 chr3:72949197 C/A cg25664220 chr3:72788482 NA -0.41 -7.36 -0.37 1.44e-12 Motion sickness; LUSC cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.51 -0.46 4.02e-19 Chronic sinus infection; LUSC cis rs4356932 1.000 rs6532093 chr4:76948032 G/A cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs9443645 0.509 rs9352668 chr6:79572678 A/G cg05283184 chr6:79620031 NA -0.52 -10.34 -0.49 6.44e-22 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.875 rs1660319 chr8:101337530 A/G cg00191853 chr8:101177733 SPAG1 -0.36 -6.03 -0.31 4.39e-9 Atrioventricular conduction; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg12432903 chr7:1882776 MAD1L1 -0.51 -8.58 -0.42 3.72e-16 Bipolar disorder and schizophrenia; LUSC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg05717871 chr11:638507 DRD4 -0.35 -6.1 -0.32 3.01e-9 Systemic lupus erythematosus; LUSC cis rs865483 0.828 rs1016680 chr17:35874385 G/T cg06716730 chr17:35851459 DUSP14 -0.26 -5.85 -0.31 1.14e-8 Monocyte count; LUSC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg11812906 chr14:75593930 NEK9 -0.67 -11.46 -0.53 7.13e-26 Height; LUSC cis rs12681287 0.640 rs7816275 chr8:87373404 A/G cg27223183 chr8:87520930 FAM82B 0.55 7.38 0.37 1.27e-12 Caudate activity during reward; LUSC cis rs4930103 0.935 rs4930101 chr11:2021859 G/T cg06197492 chr11:2016605 H19 0.41 6.65 0.34 1.2e-10 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg11062466 chr8:58055876 NA 0.49 6.48 0.33 3.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg26408565 chr15:76604113 ETFA -0.43 -6.7 -0.34 8.67e-11 Blood metabolite levels; LUSC cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2e-12 Bipolar disorder; LUSC cis rs7605827 0.897 rs7567750 chr2:15690412 C/T cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC trans rs7937682 0.961 rs4935790 chr11:111633014 T/C cg18187862 chr3:45730750 SACM1L -0.61 -7.52 -0.38 5.26e-13 Primary sclerosing cholangitis; LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg04287289 chr16:89883240 FANCA 0.78 13.77 0.6 1.85e-34 Vitiligo; LUSC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg13319975 chr6:146136371 FBXO30 0.46 6.88 0.35 2.99e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs870825 0.549 rs7699919 chr4:185648610 A/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs11098499 0.754 rs2036857 chr4:120249240 T/C cg24375607 chr4:120327624 NA 0.76 12.2 0.56 1.45e-28 Corneal astigmatism; LUSC cis rs9527 0.545 rs10218853 chr10:104796787 A/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.6 -0.34 1.58e-10 Arsenic metabolism; LUSC cis rs765787 0.505 rs11630884 chr15:45532246 C/T cg24006582 chr15:45444508 DUOX1 -0.6 -8.69 -0.43 1.64e-16 Uric acid levels; LUSC cis rs7503807 0.967 rs12947696 chr17:78596793 C/T cg09596252 chr17:78655493 RPTOR 0.41 7.05 0.36 1.04e-11 Obesity; LUSC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.81 -0.43 7.12e-17 Breast cancer; LUSC cis rs308403 0.506 rs309365 chr4:123659343 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.82 10.94 0.51 5.28e-24 Blood protein levels; LUSC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg04362960 chr10:104952993 NT5C2 0.58 9.19 0.45 4.29e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg24209194 chr3:40518798 ZNF619 0.47 6.51 0.34 2.72e-10 Renal cell carcinoma; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg10609677 chr17:41278573 BRCA1;NBR2 0.36 5.9 0.31 8.96e-9 Menopause (age at onset); LUSC cis rs909002 0.849 rs10914456 chr1:32088171 T/C cg01639898 chr1:32083012 HCRTR1 0.28 6.39 0.33 5.49e-10 Intelligence (multi-trait analysis); LUSC cis rs4842666 0.915 rs73437338 chr12:90054619 T/C cg00757033 chr12:89920650 WDR51B 0.55 7.68 0.39 1.82e-13 Blood pressure; LUSC cis rs2262909 0.962 rs11667209 chr19:22259467 A/G cg11619707 chr19:22235551 ZNF257 0.39 5.83 0.3 1.29e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9430161 0.611 rs12081197 chr1:11034239 T/C cg27631724 chr1:11040367 C1orf127 0.54 9.4 0.46 8.69e-19 Ewing sarcoma; LUSC cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC trans rs62103177 0.525 rs4283293 chr18:77759582 A/G cg14227996 chr4:17616232 MED28 -0.58 -6.47 -0.33 3.42e-10 Opioid sensitivity; LUSC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg25019033 chr10:957182 NA -0.5 -6.66 -0.34 1.16e-10 Eosinophil percentage of granulocytes; LUSC cis rs7647973 0.626 rs7649428 chr3:49868876 A/T cg03060546 chr3:49711283 APEH -0.63 -7.42 -0.38 9.68e-13 Menarche (age at onset); LUSC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.22e-10 Aortic root size; LUSC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg15445000 chr17:37608096 MED1 -0.35 -5.82 -0.3 1.38e-8 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.52 0.53 4.58e-26 Menopause (age at onset); LUSC cis rs9527 0.590 rs2281877 chr10:104866062 C/T cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC trans rs9929218 1.000 rs8044058 chr16:68807088 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -12.09 -0.55 3.58e-28 Colorectal cancer; LUSC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg14895029 chr7:2775587 GNA12 -0.41 -6.31 -0.33 9e-10 Height; LUSC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg20933634 chr6:27740509 NA -0.42 -5.68 -0.3 2.87e-8 Parkinson's disease; LUSC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg02951883 chr7:2050386 MAD1L1 -0.58 -10.44 -0.5 2.87e-22 Bipolar disorder and schizophrenia; LUSC cis rs868036 0.718 rs28587941 chr15:68122509 T/C cg24579218 chr15:68104479 NA -0.37 -6.61 -0.34 1.55e-10 Restless legs syndrome; LUSC cis rs7089973 0.604 rs11196947 chr10:116601372 G/A cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs2700987 0.692 rs2392494 chr7:37387207 T/C cg26076750 chr5:98105150 RGMB -0.36 -6.6 -0.34 1.62e-10 Psoriasis vulgaris;Psoriasis; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.5 0.42 6.19e-16 Prudent dietary pattern; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg22963979 chr7:1858916 MAD1L1 0.6 9.59 0.46 2.14e-19 Bipolar disorder and schizophrenia; LUSC cis rs1178968 1.000 rs12539763 chr7:72762429 C/T cg25889504 chr7:72793014 NA 0.56 7.49 0.38 6.01e-13 Triglyceride levels; LUSC cis rs7264396 0.790 rs6058290 chr20:34247702 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.85 -0.47 2.92e-20 Total cholesterol levels; LUSC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg07703079 chr11:430292 ANO9 0.61 6.44 0.33 4.19e-10 Body mass index; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.54 -8.09 -0.4 1.08e-14 Lymphocyte counts; LUSC cis rs950169 0.922 rs4842941 chr15:84831312 G/C cg17173187 chr15:85201210 NMB -0.37 -6.7 -0.34 8.96e-11 Schizophrenia; LUSC cis rs6961069 0.585 rs2151916 chr7:80253383 T/C cg04458919 chr7:80252533 CD36 -0.38 -6.75 -0.35 6.37e-11 Platelet count; LUSC cis rs10992471 0.702 rs10820967 chr9:95101729 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.49 -8.25 -0.41 3.75e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs1814175 0.817 rs2866863 chr11:49953242 C/T cg03929089 chr4:120376271 NA -1.04 -20.37 -0.74 1.55e-60 Height; LUSC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs7715806 0.500 rs888788 chr5:74988336 C/T cg19683494 chr5:74908142 NA 0.6 8.12 0.41 9.1e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg05585544 chr11:47624801 NA -0.42 -7.36 -0.37 1.46e-12 Subjective well-being; LUSC cis rs6688613 0.765 rs56229522 chr1:166816108 T/A cg07049167 chr1:166818506 POGK 0.5 7.44 0.38 8.86e-13 Refractive astigmatism; LUSC cis rs9457247 1.000 rs404222 chr6:167402150 G/A cg20406979 chr6:167373233 NA 0.26 5.95 0.31 6.94e-9 Crohn's disease; LUSC cis rs11122272 0.735 rs2486736 chr1:231521478 A/G cg06096015 chr1:231504339 EGLN1 -0.54 -9.61 -0.47 1.82e-19 Hemoglobin concentration; LUSC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg19318889 chr4:1322082 MAEA 0.6 10.43 0.5 3.06e-22 Longevity; LUSC cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg03060546 chr3:49711283 APEH 0.67 7.81 0.39 7.22e-14 Menarche (age at onset); LUSC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs478304 0.654 rs1074156 chr11:65458169 G/T cg27068330 chr11:65405492 SIPA1 -0.74 -10.23 -0.49 1.45e-21 Acne (severe); LUSC cis rs11048434 0.736 rs1805722 chr12:9145056 T/C cg13575925 chr12:9217583 LOC144571 0.35 6.31 0.33 8.87e-10 Sjögren's syndrome; LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg16393715 chr7:1948819 MAD1L1 0.34 5.8 0.3 1.52e-8 Bipolar disorder and schizophrenia; LUSC trans rs7951105 1.000 rs61886661 chr11:39244000 A/G cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg15017067 chr4:17643749 FAM184B 0.34 5.65 0.3 3.38e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs240110 0.570 rs966741 chr6:101218375 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.26 -0.32 1.18e-9 Neuroticism; LUSC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg20503657 chr10:835505 NA 0.77 9.17 0.45 4.8e-18 Eosinophil percentage of granulocytes; LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg23758822 chr17:41437982 NA 1.04 19.88 0.74 1.41e-58 Menopause (age at onset); LUSC cis rs921968 0.643 rs3931102 chr2:219520405 C/T cg02176678 chr2:219576539 TTLL4 0.58 10.5 0.5 1.76e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.52 -7.87 -0.4 4.86e-14 Prudent dietary pattern; LUSC trans rs2665103 0.655 rs1501367 chr15:82522816 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.4 -0.33 5.18e-10 Intelligence (multi-trait analysis); LUSC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg00677455 chr12:58241039 CTDSP2 0.61 8.47 0.42 7.68e-16 Multiple sclerosis; LUSC cis rs2279817 0.780 rs79923328 chr1:18008116 T/C cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.13 -0.32 2.54e-9 Neuroticism; LUSC cis rs17401966 0.931 rs4846205 chr1:10310214 A/T cg19773385 chr1:10388646 KIF1B -0.59 -10.09 -0.48 4.5e-21 Hepatocellular carcinoma; LUSC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg24209194 chr3:40518798 ZNF619 -0.45 -6.3 -0.33 9.52e-10 Renal cell carcinoma; LUSC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.97 19.48 0.73 5.37e-57 Height; LUSC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg04369109 chr6:150039330 LATS1 0.55 7.5 0.38 5.65e-13 Lung cancer; LUSC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg03526776 chr6:41159608 TREML2 0.32 6.07 0.32 3.44e-9 Alzheimer's disease (late onset); LUSC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg16447950 chr5:562315 NA -0.54 -6.76 -0.35 6.15e-11 Obesity-related traits; LUSC cis rs11645898 0.872 rs72787070 chr16:72151101 T/C cg14768367 chr16:72042858 DHODH -0.66 -7.51 -0.38 5.44e-13 Blood protein levels; LUSC cis rs7618501 1.000 rs3749241 chr3:49744392 A/G cg13072238 chr3:49761600 GMPPB -0.39 -6.36 -0.33 6.55e-10 Intelligence (multi-trait analysis); LUSC trans rs9291683 0.588 rs35099040 chr4:10018839 T/C cg26043149 chr18:55253948 FECH 0.49 7.47 0.38 7.27e-13 Bone mineral density; LUSC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.95 -0.31 6.6e-9 Tonsillectomy; LUSC cis rs7945705 0.846 rs4929912 chr11:8816695 A/G cg12365402 chr11:9010492 NRIP3 -0.41 -7.37 -0.37 1.38e-12 Hemoglobin concentration; LUSC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.46 0.38 7.35e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg12463550 chr7:65579703 CRCP 0.49 7.1 0.36 7.77e-12 Aortic root size; LUSC cis rs7923609 0.841 rs10761786 chr10:65336207 T/C cg01631684 chr10:65280961 REEP3 -0.41 -6.42 -0.33 4.76e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7605827 0.930 rs7596951 chr2:15513473 G/C cg19274914 chr2:15703543 NA 0.46 8.89 0.44 3.76e-17 Educational attainment (years of education); LUSC cis rs7107174 0.688 rs11237489 chr11:78130325 G/A cg02023728 chr11:77925099 USP35 0.43 6.6 0.34 1.64e-10 Testicular germ cell tumor; LUSC cis rs6696846 0.740 rs17344537 chr1:205091427 T/G cg21643547 chr1:205240462 TMCC2 -0.41 -7.55 -0.38 4.08e-13 Red blood cell count; LUSC trans rs853679 0.599 rs188015 chr6:27877446 T/A cg06606381 chr12:133084897 FBRSL1 -0.71 -7.15 -0.36 5.52e-12 Depression; LUSC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg25204440 chr1:209979598 IRF6 0.5 5.72 0.3 2.36e-8 Cleft lip with or without cleft palate; LUSC cis rs17095355 0.605 rs2274979 chr10:111631781 G/A cg00817464 chr10:111662876 XPNPEP1 -0.56 -6.46 -0.33 3.63e-10 Biliary atresia; LUSC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg17443473 chr1:3703550 LRRC47 0.32 5.68 0.3 2.96e-8 Red cell distribution width; LUSC cis rs12681287 0.752 rs4310184 chr8:87245253 T/C cg27223183 chr8:87520930 FAM82B -0.46 -5.82 -0.3 1.4e-8 Caudate activity during reward; LUSC cis rs4664308 0.810 rs59019419 chr2:161061287 G/A cg03641300 chr2:160917029 PLA2R1 -0.62 -10.65 -0.5 5.47e-23 Idiopathic membranous nephropathy; LUSC cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.77e-30 Motion sickness; LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg14789911 chr21:47582049 C21orf56 -0.42 -6.59 -0.34 1.7e-10 Testicular germ cell tumor; LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.52e-9 Menopause (age at onset); LUSC cis rs8060686 0.641 rs55725810 chr16:68189636 C/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.24 -0.37 3.08e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs71403859 0.502 rs34766979 chr16:71475511 G/A cg08717414 chr16:71523259 ZNF19 -0.72 -8.08 -0.4 1.17e-14 Post bronchodilator FEV1; LUSC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.76 -0.35 6.33e-11 Alzheimer's disease (late onset); LUSC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg14829155 chr15:31115871 NA -0.57 -7.92 -0.4 3.5e-14 Huntington's disease progression; LUSC cis rs4704187 0.687 rs4324655 chr5:74373360 C/T cg03227963 chr5:74354835 NA 0.33 7.11 0.36 7.31e-12 Response to amphetamines; LUSC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.2 0.32 1.62e-9 Mean platelet volume; LUSC trans rs61931739 0.500 rs11053272 chr12:34547020 C/G cg26384229 chr12:38710491 ALG10B 0.9 15.53 0.65 2.54e-41 Morning vs. evening chronotype; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.6 0.34 1.63e-10 Obesity-related traits; LUSC cis rs897080 0.552 rs1067318 chr2:44634509 A/C cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs6084875 0.840 rs6052816 chr20:4725086 T/C cg26097573 chr20:4721490 PRNT -0.31 -5.76 -0.3 1.87e-8 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18147309 chr17:65362822 PSMD12 -0.41 -6.05 -0.31 3.85e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21332495 chr17:41476307 ARL4D -0.45 -6.84 -0.35 3.75e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9790314 0.521 rs1376122 chr3:161087857 A/G cg03342759 chr3:160939853 NMD3 -0.41 -5.98 -0.31 5.71e-9 Morning vs. evening chronotype; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03672602 chr19:19754555 GMIP 0.46 6.5 0.34 2.96e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg03354898 chr7:1950403 MAD1L1 -0.34 -6.64 -0.34 1.25e-10 Bipolar disorder and schizophrenia; LUSC cis rs9326248 0.530 rs11216171 chr11:116749113 T/A cg11861562 chr11:117069780 TAGLN 0.37 6.34 0.33 7.54e-10 Blood protein levels; LUSC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21659725 chr3:3221576 CRBN 0.89 18.73 0.72 4.89e-54 Intelligence (multi-trait analysis); LUSC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg19468946 chr17:37922297 IKZF3 -0.44 -6.93 -0.35 2.22e-11 Self-reported allergy; LUSC trans rs60843830 1.000 rs7595075 chr2:264019 C/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.17 0.49 2.39e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg16339924 chr4:17578868 LAP3 0.58 8.85 0.44 5.14e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23615779 chr7:143077590 ZYX 0.5 6.85 0.35 3.52e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg03264133 chr6:25882463 NA -0.5 -9.04 -0.44 1.33e-17 Blood metabolite levels; LUSC cis rs11585357 0.947 rs11585118 chr1:17605774 C/A cg08277548 chr1:17600880 PADI3 -0.68 -6.88 -0.35 2.88e-11 Hair shape; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00961003 chr20:3748878 C20orf27 0.42 5.95 0.31 6.71e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2041895 0.527 rs10861681 chr12:107334262 C/T cg13944111 chr12:107296891 NA 0.36 6.7 0.34 8.74e-11 Glaucoma (low intraocular pressure); LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg00945038 chr17:61921165 SMARCD2 0.54 9.64 0.47 1.44e-19 Prudent dietary pattern; LUSC cis rs72781680 0.660 rs72780104 chr2:23983715 A/G cg20701182 chr2:24300061 SF3B14 0.56 6.0 0.31 5.19e-9 Lymphocyte counts; LUSC cis rs6960043 1.000 rs12113083 chr7:15051943 G/C cg19272540 chr7:15055459 NA -0.29 -6.94 -0.35 2.05e-11 Type 2 diabetes; LUSC cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.6 0.43 3.14e-16 Hip circumference adjusted for BMI; LUSC cis rs9309473 1.000 rs6755241 chr2:73641364 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.46 -0.33 3.74e-10 Metabolite levels; LUSC cis rs6964587 1.000 rs10243241 chr7:91705696 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.5e-8 Breast cancer; LUSC cis rs9467773 0.620 rs2451711 chr6:26663110 A/G cg11502198 chr6:26597334 ABT1 0.73 12.27 0.56 7.72e-29 Intelligence (multi-trait analysis); LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg13047869 chr3:10149882 C3orf24 0.57 8.41 0.42 1.22e-15 Alzheimer's disease; LUSC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.51 7.89 0.4 4.33e-14 Eosinophil percentage of white cells; LUSC cis rs2639990 1.000 rs655156 chr18:72898181 T/C cg02750262 chr18:72916776 ZADH2 0.63 7.39 0.37 1.22e-12 Vascular endothelial growth factor levels; LUSC cis rs4906332 1.000 rs1951389 chr14:103898525 G/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.46e-12 Coronary artery disease; LUSC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg03213289 chr20:61660250 NA -0.61 -12.25 -0.56 9.49e-29 Prostate cancer (SNP x SNP interaction); LUSC cis rs11642862 1.000 rs74483355 chr16:30836430 C/T cg02466173 chr16:30829666 NA -0.7 -7.33 -0.37 1.71e-12 Tonsillectomy; LUSC cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg01579765 chr21:45077557 HSF2BP -0.5 -10.49 -0.5 1.89e-22 Mean corpuscular volume; LUSC cis rs4595586 0.525 rs7977228 chr12:39395060 A/G cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.04 0.36 1.07e-11 Schizophrenia; LUSC cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.39 -0.37 1.22e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg13877915 chr19:58951672 ZNF132 0.46 7.39 0.38 1.16e-12 Uric acid clearance; LUSC cis rs8060686 0.516 rs2290700 chr16:68288983 T/G cg09835421 chr16:68378352 PRMT7 -0.52 -6.35 -0.33 6.98e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs763121 0.706 rs3827356 chr22:39064806 G/T cg06022373 chr22:39101656 GTPBP1 -0.68 -10.59 -0.5 8.37e-23 Menopause (age at onset); LUSC cis rs6696846 1.000 rs6696846 chr1:205041952 C/T cg21545522 chr1:205238299 TMCC2 0.43 7.94 0.4 3.18e-14 Red blood cell count; LUSC cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.69 -0.3 2.73e-8 Bipolar disorder; LUSC cis rs877282 0.898 rs71489279 chr10:760510 T/C cg17470449 chr10:769945 NA 0.52 7.36 0.37 1.42e-12 Uric acid levels; LUSC cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg12379764 chr21:47803548 PCNT -0.57 -7.85 -0.39 5.66e-14 Testicular germ cell tumor; LUSC trans rs338389 0.586 rs338390 chr15:68259214 A/G cg16317052 chr17:61678891 TACO1 0.38 5.99 0.31 5.4e-9 Survival in rectal cancer; LUSC cis rs859767 0.741 rs4954156 chr2:135395863 T/C cg12500956 chr2:135428796 TMEM163 -0.28 -6.24 -0.32 1.3e-9 Neuroticism; LUSC cis rs7615316 0.844 rs7641330 chr3:142305638 T/C cg16271453 chr3:142027066 XRN1 -0.36 -6.03 -0.31 4.41e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg14061069 chr19:46274453 DMPK 0.67 13.9 0.61 5.85e-35 Coronary artery disease; LUSC cis rs9325144 0.647 rs10875953 chr12:39050536 G/C cg26384229 chr12:38710491 ALG10B -0.62 -9.51 -0.46 3.84e-19 Morning vs. evening chronotype; LUSC cis rs11112613 0.762 rs73184077 chr12:105949999 G/A cg03607813 chr12:105948248 NA 0.82 12.44 0.56 1.96e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg22105103 chr4:187893119 NA 0.72 14.09 0.61 1e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs12760731 0.623 rs10913539 chr1:178336682 T/C cg00404053 chr1:178313656 RASAL2 0.47 5.67 0.3 3.02e-8 Obesity-related traits; LUSC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.02 -0.36 1.22e-11 Lung cancer; LUSC cis rs1008375 0.966 rs1860591 chr4:17577329 A/G cg16339924 chr4:17578868 LAP3 0.59 9.27 0.45 2.38e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg26446133 chr18:72167187 CNDP2 -0.81 -9.95 -0.48 1.35e-20 Refractive error; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg22907277 chr7:1156413 C7orf50 0.48 7.35 0.37 1.5e-12 Longevity;Endometriosis; LUSC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.81 0.35 4.61e-11 Schizophrenia; LUSC cis rs2455601 0.882 rs11042105 chr11:8894510 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -7.21 -0.37 3.87e-12 Schizophrenia; LUSC trans rs8073060 0.586 rs6505486 chr17:33996776 G/A cg19694781 chr19:47549865 TMEM160 -1.15 -18.43 -0.71 8.08e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.2 0.61 3.9e-36 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1577917 0.761 rs117452258 chr6:86554211 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.68 -0.43 1.76e-16 Response to antipsychotic treatment; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18493069 chr6:108582623 SNX3 0.37 6.38 0.33 5.76e-10 Triglycerides; LUSC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg16524733 chr11:117070046 TAGLN -0.39 -6.84 -0.35 3.67e-11 Blood protein levels; LUSC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.55 0.46 2.98e-19 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs6752107 1.000 rs3792112 chr2:234176609 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.81 0.54 3.83e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg05872129 chr22:39784769 NA 0.6 11.56 0.53 3.15e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs17685 0.753 rs10085567 chr7:75734206 A/C cg19862616 chr7:65841803 NCRNA00174 1.11 19.03 0.72 3.14e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7119 0.667 rs907390 chr15:77902419 T/C cg27398640 chr15:77910606 LINGO1 0.37 8.79 0.43 7.86e-17 Type 2 diabetes; LUSC trans rs7916697 0.520 rs4745957 chr10:70044702 A/G cg04882175 chr6:131122610 NA 0.47 6.12 0.32 2.56e-9 Optic disc area; LUSC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.87 -0.35 3.19e-11 Total body bone mineral density; LUSC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg08470875 chr2:26401718 FAM59B 0.72 9.9 0.48 1.91e-20 Gut microbiome composition (summer); LUSC cis rs9311676 0.656 rs7647184 chr3:58370046 C/T cg26110898 chr3:58419937 PDHB 0.42 6.72 0.35 7.93e-11 Systemic lupus erythematosus; LUSC cis rs10752881 1.000 rs4593781 chr1:182984983 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg04455712 chr21:45112962 RRP1B 0.46 8.78 0.43 8.54e-17 Mean corpuscular volume; LUSC cis rs9300255 0.770 rs7980687 chr12:123822711 G/A cg13010344 chr12:123464640 ARL6IP4 0.49 6.27 0.32 1.11e-9 Neutrophil percentage of white cells; LUSC cis rs6500602 0.727 rs11644481 chr16:4581002 T/G cg08645402 chr16:4508243 NA 0.51 8.61 0.43 3.01e-16 Schizophrenia; LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.74 -0.57 1.37e-30 Alzheimer's disease; LUSC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs10489202 0.632 rs275137 chr1:168051266 A/C cg24449463 chr1:168025552 DCAF6 0.77 12.87 0.58 4.52e-31 Schizophrenia; LUSC cis rs951366 0.539 rs1935025 chr1:205692084 C/A cg07167872 chr1:205819463 PM20D1 -0.43 -5.92 -0.31 8.16e-9 Menarche (age at onset); LUSC cis rs710216 0.843 rs3768043 chr1:43419354 C/A cg03128534 chr1:43423976 SLC2A1 -0.5 -6.54 -0.34 2.33e-10 Red cell distribution width; LUSC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg21665744 chr7:39171113 POU6F2 0.5 7.85 0.39 5.53e-14 IgG glycosylation; LUSC cis rs921968 0.643 rs2278530 chr2:219501133 G/A cg02176678 chr2:219576539 TTLL4 0.6 10.86 0.51 9.63e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs17270561 0.609 rs12203927 chr6:25732690 A/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg27165867 chr14:105738592 BRF1 -0.53 -7.91 -0.4 3.8e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg07703079 chr11:430292 ANO9 0.65 6.68 0.34 1.03e-10 Body mass index; LUSC cis rs6500395 0.962 rs868792 chr16:48640632 T/C cg04672837 chr16:48644449 N4BP1 0.47 6.99 0.36 1.48e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.38 0.46 1.04e-18 Monocyte percentage of white cells; LUSC cis rs9527 0.615 rs7917295 chr10:104701187 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.37 0.46 1.13e-18 Arsenic metabolism; LUSC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg18402987 chr7:1209562 NA 0.43 5.69 0.3 2.73e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10752881 1.000 rs4304541 chr1:182970238 G/T ch.1.3577855R chr1:183094577 LAMC1 0.67 10.29 0.49 9.56e-22 Colorectal cancer; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg01198024 chr21:33672713 MRAP -0.41 -6.08 -0.32 3.36e-9 Neuroticism; LUSC cis rs314370 0.904 rs13244629 chr7:100509253 A/C cg08558340 chr7:100472263 SRRT 0.51 6.38 0.33 5.82e-10 Resting heart rate; LUSC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg21724239 chr8:58056113 NA 0.57 6.58 0.34 1.84e-10 Developmental language disorder (linguistic errors); LUSC trans rs11098499 1.000 rs6837898 chr4:120179154 C/T cg25214090 chr10:38739885 LOC399744 0.48 7.02 0.36 1.28e-11 Corneal astigmatism; LUSC trans rs11722228 0.522 rs881641 chr4:10133747 G/A cg26043149 chr18:55253948 FECH 1.02 16.24 0.66 3.98e-44 Gout;Urate levels;Serum uric acid levels; LUSC cis rs1018836 0.631 rs61276517 chr8:91474406 A/G cg16814680 chr8:91681699 NA -0.58 -8.68 -0.43 1.84e-16 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg06212747 chr3:49208901 KLHDC8B -0.53 -7.54 -0.38 4.5e-13 Menarche (age at onset); LUSC cis rs4911259 0.533 rs6058931 chr20:31471012 C/T cg13636640 chr20:31349939 DNMT3B -0.82 -15.77 -0.65 2.83e-42 Inflammatory bowel disease; LUSC cis rs10465746 0.746 rs6699501 chr1:84389993 A/G cg10977910 chr1:84465055 TTLL7 0.44 6.36 0.33 6.81e-10 Obesity-related traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02667081 chr16:71880439 ATXN1L 0.46 6.75 0.35 6.61e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17401966 0.838 rs4475756 chr1:10387788 A/G cg19773385 chr1:10388646 KIF1B -0.51 -9.04 -0.44 1.3e-17 Hepatocellular carcinoma; LUSC cis rs9581857 0.556 rs1885991 chr13:28040470 G/A cg22138327 chr13:27999177 GTF3A 0.7 9.5 0.46 4.1e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs4409675 0.576 rs6660899 chr1:28214281 G/C cg23691781 chr1:28212827 C1orf38 0.32 7.59 0.38 3.28e-13 Corneal astigmatism; LUSC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7474896 0.583 rs4934898 chr10:37990395 G/C cg25427524 chr10:38739819 LOC399744 -0.51 -7.05 -0.36 1.04e-11 Obesity (extreme); LUSC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg25456477 chr12:86230367 RASSF9 0.33 5.82 0.3 1.39e-8 Major depressive disorder; LUSC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg00701064 chr4:6280414 WFS1 -0.58 -14.0 -0.61 2.4e-35 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2273669 0.667 rs12195728 chr6:109278873 A/G cg05315195 chr6:109294784 ARMC2 -0.6 -6.58 -0.34 1.86e-10 Prostate cancer; LUSC cis rs9902453 0.833 rs7216631 chr17:28495112 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.84 0.44 5.42e-17 Coffee consumption (cups per day); LUSC cis rs68170813 0.652 rs7807154 chr7:107161391 T/G cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg17261708 chr5:176794207 RGS14 0.33 5.77 0.3 1.8e-8 Hemoglobin concentration;Hematocrit; LUSC trans rs12637928 0.580 rs13088261 chr3:110256470 T/C cg17371621 chr15:61264283 RORA 0.36 5.97 0.31 5.94e-9 Neuroticism; LUSC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg22467129 chr15:76604101 ETFA 0.43 6.79 0.35 5.1e-11 Blood metabolite levels; LUSC cis rs7246967 0.673 rs7250343 chr19:22822845 A/G cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg25072359 chr17:41440525 NA 0.57 8.33 0.41 2.08e-15 Menopause (age at onset); LUSC cis rs13256369 0.802 rs34762800 chr8:8559294 G/A cg18904891 chr8:8559673 CLDN23 0.6 7.9 0.4 4.13e-14 Obesity-related traits; LUSC cis rs4234798 0.500 rs10937793 chr4:7219614 C/T cg18431297 chr4:7219810 SORCS2 0.33 6.21 0.32 1.55e-9 Insulin-like growth factors; LUSC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg23283495 chr1:209979779 IRF6 0.68 8.38 0.42 1.51e-15 Cleft lip with or without cleft palate; LUSC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg01657329 chr11:68192670 LRP5 0.45 7.24 0.37 3.17e-12 Total body bone mineral density; LUSC cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg09184832 chr6:79620586 NA 0.4 6.37 0.33 6.35e-10 Intelligence (multi-trait analysis); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03247675 chr19:10812111 QTRT1 0.41 6.44 0.33 4.28e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs877282 0.891 rs12767062 chr10:797961 C/T cg17470449 chr10:769945 NA 0.5 6.9 0.35 2.7e-11 Uric acid levels; LUSC cis rs10744422 0.800 rs2343110 chr12:123343571 T/G cg25930673 chr12:123319894 HIP1R -0.65 -6.67 -0.34 1.08e-10 Schizophrenia; LUSC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg19912559 chr1:40204330 PPIE 0.54 8.26 0.41 3.35e-15 Blood protein levels; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg08200582 chr11:442649 ANO9 -0.53 -5.74 -0.3 2.07e-8 Body mass index; LUSC cis rs9326248 0.559 rs12808524 chr11:116890993 T/C cg26566898 chr11:117069891 TAGLN 0.34 6.4 0.33 5.37e-10 Blood protein levels; LUSC cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11105298 0.891 rs10858889 chr12:89902604 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.38 -0.37 1.28e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg06238570 chr21:40685208 BRWD1 -0.61 -10.36 -0.49 5.54e-22 Cognitive function; LUSC cis rs9929218 0.551 rs3785133 chr16:68728611 C/T cg01251360 chr16:68772225 CDH1 -0.25 -5.96 -0.31 6.49e-9 Colorectal cancer; LUSC cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg21573476 chr21:45109991 RRP1B -0.41 -6.46 -0.33 3.77e-10 Mean corpuscular volume; LUSC cis rs10779751 0.734 rs2791657 chr1:11128001 A/G cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg00509249 chr6:109615579 CCDC162 -0.34 -6.09 -0.32 3.11e-9 Reticulocyte fraction of red cells; LUSC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg12963246 chr6:28129442 ZNF389 0.4 5.99 0.31 5.44e-9 Cardiac Troponin-T levels; LUSC cis rs600231 0.542 rs11227205 chr11:65256164 G/A cg17120908 chr11:65337727 SSSCA1 -0.63 -9.12 -0.45 7.22e-18 Bone mineral density; LUSC trans rs10432489 0.708 rs3922471 chr2:181771937 T/C cg16818443 chr4:2965195 GRK4;NOP14 0.82 6.01 0.31 4.74e-9 QT interval; LUSC trans rs11696501 0.688 rs6073862 chr20:44331705 T/C cg03272292 chr12:48577362 C12orf68 0.51 6.05 0.31 3.87e-9 Brain structure; LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg00166722 chr3:10149974 C3orf24 0.56 7.54 0.38 4.61e-13 Alzheimer's disease; LUSC cis rs977987 0.843 rs10459859 chr16:75381950 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.82 -0.35 4.37e-11 Dupuytren's disease; LUSC cis rs7267979 0.816 rs409853 chr20:25506067 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.57 0.67 2.05e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg11812906 chr14:75593930 NEK9 -0.66 -11.14 -0.52 1.03e-24 Height; LUSC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg00857998 chr1:205179979 DSTYK 0.64 9.83 0.47 3.41e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs72634258 0.554 rs1012477 chr1:7858135 C/G cg26816564 chr1:7831052 VAMP3 -0.92 -12.96 -0.58 2.13e-31 Inflammatory bowel disease; LUSC trans rs6952808 0.723 rs1107592 chr7:2041432 C/T cg04565464 chr8:145669602 NFKBIL2 -0.36 -6.06 -0.31 3.74e-9 Bipolar disorder and schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04579064 chr14:104029527 BAG5;C14orf153 -0.46 -6.06 -0.31 3.7e-9 Hepatitis; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg13987042 chr11:74660265 XRRA1;SPCS2 -0.49 -6.19 -0.32 1.8e-9 Cognitive function;Information processing speed; LUSC cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg23711669 chr6:146136114 FBXO30 0.86 15.54 0.65 2.4e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs9517320 1.000 rs9513430 chr13:99127252 C/G cg07423050 chr13:99094983 FARP1 0.33 6.22 0.32 1.48e-9 Longevity; LUSC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg18827107 chr12:86230957 RASSF9 -0.44 -6.61 -0.34 1.48e-10 Major depressive disorder; LUSC cis rs116988415 1.000 rs11622962 chr14:65299145 C/T cg00114569 chr14:65239327 SPTB 0.54 5.75 0.3 1.98e-8 Daytime sleep phenotypes; LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg20090143 chr19:45452003 APOC2 -0.47 -8.87 -0.44 4.61e-17 Blood protein levels; LUSC cis rs6736093 0.966 rs35189728 chr2:112720228 C/G cg12686935 chr2:112915763 FBLN7 -0.37 -6.03 -0.31 4.39e-9 Coronary artery disease; LUSC cis rs7953508 0.711 rs11107117 chr12:93979419 T/C cg18151635 chr12:93972918 NA -0.59 -8.12 -0.41 9.03e-15 Pubertal anthropometrics; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.97 0.77 8.25e-67 Prudent dietary pattern; LUSC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg18876405 chr7:65276391 NA 0.56 9.16 0.45 5.5e-18 Aortic root size; LUSC cis rs6743226 1.000 rs6743226 chr2:242236972 T/C cg10021735 chr2:242295487 FARP2 0.36 5.67 0.3 3.17e-8 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; LUSC cis rs2710642 0.777 rs2539987 chr2:63142864 A/G cg17519650 chr2:63277830 OTX1 0.52 7.31 0.37 1.93e-12 LDL cholesterol levels;LDL cholesterol; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg13397359 chr6:42928475 GNMT 0.64 10.68 0.5 4.16e-23 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7615316 0.902 rs6440092 chr3:142313987 T/A cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.58e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.75 11.25 0.52 4.01e-25 Multiple sclerosis; LUSC cis rs79387448 0.638 rs11465670 chr2:103034440 A/G cg09003973 chr2:102972529 NA 0.96 10.03 0.48 7.18e-21 Gut microbiota (bacterial taxa); LUSC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.27 0.59 1.39e-32 Hip circumference adjusted for BMI; LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg10729496 chr3:10149963 C3orf24 0.54 7.15 0.36 5.46e-12 Alzheimer's disease; LUSC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg21770322 chr7:97807741 LMTK2 0.4 6.84 0.35 3.82e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7712401 0.791 rs6872932 chr5:122145636 A/G cg19077854 chr5:122220652 SNX24 0.35 7.95 0.4 2.84e-14 Mean platelet volume; LUSC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg06108461 chr20:60628389 TAF4 -0.73 -11.85 -0.54 2.87e-27 Body mass index; LUSC cis rs9303401 0.614 rs2333409 chr17:57139134 G/A cg25039879 chr17:56429692 SUPT4H1 0.66 8.73 0.43 1.23e-16 Cognitive test performance; LUSC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg01652190 chr22:50026171 C22orf34 -0.3 -6.21 -0.32 1.59e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg18964960 chr10:1102726 WDR37 0.44 6.01 0.31 4.94e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs2235649 0.833 rs9929185 chr16:1852070 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -6.02 -0.31 4.48e-9 Blood metabolite levels; LUSC cis rs9388451 0.839 rs3966775 chr6:126067655 C/A cg10911889 chr6:126070802 HEY2 0.42 6.39 0.33 5.72e-10 Brugada syndrome; LUSC cis rs12620999 0.838 rs13007071 chr2:238038755 A/G cg23555395 chr2:238036564 NA -0.53 -8.94 -0.44 2.77e-17 Systemic lupus erythematosus; LUSC trans rs2188420 0.745 rs849395 chr7:106586497 T/C cg04262465 chr14:101405693 SNORD113-6 -0.42 -6.37 -0.33 6.13e-10 Interferon gamma levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00996262 chr17:7554930 ATP1B2 0.63 5.96 0.31 6.42e-9 Cognitive performance; LUSC cis rs7615316 0.902 rs6440093 chr3:142316036 A/G cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.58e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs16976116 0.901 rs73409853 chr15:55502681 A/T cg11288833 chr15:55489084 RSL24D1 0.51 6.16 0.32 2.05e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2762353 0.935 rs1183200 chr6:25818646 G/C cg03517284 chr6:25882590 NA -0.46 -8.19 -0.41 5.6e-15 Blood metabolite levels; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg00576301 chr13:36920965 SPG20 0.47 6.08 0.32 3.35e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg12432903 chr7:1882776 MAD1L1 -0.36 -5.82 -0.3 1.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg12927641 chr6:109611667 NA -0.35 -5.9 -0.31 8.95e-9 Reticulocyte fraction of red cells; LUSC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.83 0.3 1.33e-8 Menopause (age at onset); LUSC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs11764590 0.694 rs6461115 chr7:2103668 A/G cg19629631 chr7:2060116 MAD1L1 -0.36 -5.68 -0.3 2.87e-8 Neuroticism; LUSC cis rs2692947 0.759 rs2949885 chr2:96662415 A/G cg22654517 chr2:96458247 NA 0.31 5.94 0.31 7.08e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg24675658 chr1:53192096 ZYG11B -0.73 -12.49 -0.56 1.25e-29 Monocyte count; LUSC cis rs9807989 0.507 rs7581119 chr2:103049865 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.98e-12 Asthma; LUSC cis rs11190604 1.000 rs11190601 chr10:102296730 A/G cg16342193 chr10:102329863 NA -0.36 -6.6 -0.34 1.65e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs478304 0.654 rs1074155 chr11:65458197 C/T cg27068330 chr11:65405492 SIPA1 0.74 10.25 0.49 1.26e-21 Acne (severe); LUSC cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg22508957 chr16:3507546 NAT15 0.43 6.32 0.33 8.2e-10 Body mass index (adult); LUSC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs7712401 0.686 rs246305 chr5:122199606 A/T cg19077854 chr5:122220652 SNX24 0.32 7.17 0.37 4.99e-12 Mean platelet volume; LUSC cis rs11997175 0.625 rs953617 chr8:33599158 G/C ch.8.33884649F chr8:33765107 NA 0.42 6.78 0.35 5.33e-11 Body mass index; LUSC cis rs7091068 0.518 rs726817 chr10:95459817 C/T cg20715218 chr10:95462985 C10orf4 0.47 5.97 0.31 6.1e-9 Urinary tract infection frequency; LUSC cis rs9549260 0.753 rs9532562 chr13:41153585 A/G cg21288729 chr13:41239152 FOXO1 0.58 6.78 0.35 5.58e-11 Red blood cell count; LUSC cis rs5750830 0.594 rs9611165 chr22:39775250 A/G cg02038168 chr22:39784481 NA -0.48 -7.72 -0.39 1.35e-13 Intelligence (multi-trait analysis); LUSC cis rs1322512 0.917 rs2038616 chr6:153022674 T/C cg27316956 chr6:152958899 SYNE1 0.36 6.17 0.32 1.92e-9 Tonometry; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg27170947 chr2:26402098 FAM59B -0.69 -10.55 -0.5 1.2e-22 Gut microbiome composition (summer); LUSC cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg25427524 chr10:38739819 LOC399744 0.41 6.86 0.35 3.38e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7647973 0.626 rs4855882 chr3:49715354 G/T cg03060546 chr3:49711283 APEH 0.66 7.47 0.38 7.11e-13 Menarche (age at onset); LUSC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.25e-8 Aortic root size; LUSC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg08677398 chr8:58056175 NA 0.52 6.92 0.35 2.27e-11 Developmental language disorder (linguistic errors); LUSC cis rs1670533 1.000 rs7669622 chr4:1058659 A/G cg27284194 chr4:1044797 NA 0.58 8.52 0.42 5.71e-16 Recombination rate (females); LUSC cis rs2219968 0.701 rs2200015 chr8:78990829 T/C cg00738934 chr8:78996279 NA 0.43 7.88 0.4 4.51e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9902453 0.791 rs55655651 chr17:28244286 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.64 9.98 0.48 1.04e-20 Coffee consumption (cups per day); LUSC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg21724239 chr8:58056113 NA 0.56 6.86 0.35 3.37e-11 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19726916 chr19:17420182 DDA1 0.41 5.97 0.31 6.19e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs853679 0.517 rs9393886 chr6:28050039 T/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.7 0.51 3.69e-23 Bone mineral density; LUSC cis rs10791323 0.569 rs2187450 chr11:133743792 A/G cg15485101 chr11:133734466 NA 0.38 7.17 0.37 4.98e-12 Childhood ear infection; LUSC cis rs6121246 0.529 rs6058152 chr20:30178107 G/A cg13852791 chr20:30311386 BCL2L1 0.71 8.05 0.4 1.49e-14 Mean corpuscular hemoglobin; LUSC cis rs9747201 1.000 rs12943668 chr17:80109930 C/T cg18209359 chr17:80159595 CCDC57 0.39 6.44 0.33 4.06e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7666738 0.546 rs13148080 chr4:98680947 A/G cg17366294 chr4:99064904 C4orf37 0.53 8.27 0.41 3.15e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs701145 0.938 rs355788 chr3:154000612 T/C cg17054900 chr3:154042577 DHX36 0.84 8.49 0.42 6.84e-16 Coronary artery disease; LUSC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg03709012 chr19:19516395 GATAD2A -0.82 -13.01 -0.58 1.39e-31 Tonsillectomy; LUSC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg22800045 chr5:56110881 MAP3K1 0.46 5.97 0.31 5.93e-9 Coronary artery disease; LUSC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg15556689 chr8:8085844 FLJ10661 0.48 6.2 0.32 1.69e-9 Obesity-related traits; LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.66 0.6 4.84e-34 Platelet count; LUSC cis rs67366981 1.000 rs67366981 chr14:77703964 T/C cg22824376 chr14:77648248 TMEM63C 0.68 6.38 0.33 5.76e-10 Obsessive-compulsive symptoms; LUSC cis rs782590 0.537 rs12619903 chr2:55884106 T/A cg03859395 chr2:55845619 SMEK2 -0.63 -8.79 -0.43 8.07e-17 Metabolic syndrome; LUSC cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg21535247 chr6:8435926 SLC35B3 0.58 8.84 0.44 5.51e-17 Motion sickness; LUSC cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.36 -0.42 1.71e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg22029157 chr1:209979665 IRF6 0.81 10.42 0.5 3.33e-22 Cleft lip with or without cleft palate; LUSC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs911555 0.755 rs34411783 chr14:103900639 G/A cg24130564 chr14:104152367 KLC1 0.45 6.42 0.33 4.6e-10 Intelligence (multi-trait analysis); LUSC trans rs4650994 0.525 rs2493865 chr1:178545016 G/A cg05059571 chr16:84539110 KIAA1609 0.48 9.18 0.45 4.59e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg09060608 chr5:178986726 RUFY1 0.63 10.93 0.51 5.56e-24 Lung cancer; LUSC cis rs6556937 0.562 rs31250 chr5:96013441 G/C cg07690455 chr5:95997198 CAST 0.48 6.6 0.34 1.62e-10 Blood protein levels; LUSC cis rs116095464 0.558 rs10060089 chr5:205565 G/A cg22496380 chr5:211416 CCDC127 -0.85 -8.68 -0.43 1.72e-16 Breast cancer; LUSC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg02487422 chr3:49467188 NICN1 -0.42 -5.88 -0.31 9.94e-9 Menarche (age at onset); LUSC cis rs1178968 1.000 rs7802062 chr7:72757812 T/C cg25889504 chr7:72793014 NA 0.58 7.54 0.38 4.5e-13 Triglyceride levels; LUSC cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg00071950 chr4:10020882 SLC2A9 0.63 10.52 0.5 1.55e-22 Bone mineral density; LUSC cis rs262147 0.610 rs2657363 chr7:158684273 C/T cg24397884 chr7:158709396 WDR60 0.71 6.01 0.31 4.97e-9 Hippocampal volume; LUSC cis rs9653442 0.545 rs11123810 chr2:100759285 T/C cg22139774 chr2:100720529 AFF3 -0.43 -7.33 -0.37 1.73e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05901451 chr6:126070800 HEY2 -0.76 -13.51 -0.59 1.73e-33 Brugada syndrome; LUSC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg04414720 chr1:150670196 GOLPH3L 0.5 7.9 0.4 4.13e-14 Melanoma; LUSC cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg12463550 chr7:65579703 CRCP -0.48 -6.92 -0.35 2.31e-11 Aortic root size; LUSC trans rs11098499 0.909 rs10014719 chr4:120320715 G/A cg25214090 chr10:38739885 LOC399744 0.54 7.9 0.4 4.18e-14 Corneal astigmatism; LUSC cis rs35306767 0.714 rs7072554 chr10:1090988 C/T cg20503657 chr10:835505 NA 0.55 7.25 0.37 2.89e-12 Eosinophil percentage of granulocytes; LUSC cis rs9650657 0.537 rs4841457 chr8:10773511 T/G cg27411982 chr8:10470053 RP1L1 -0.49 -7.61 -0.38 2.84e-13 Neuroticism; LUSC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg02569458 chr12:86230093 RASSF9 -0.52 -8.78 -0.43 8.37e-17 Major depressive disorder; LUSC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg08219700 chr8:58056026 NA 0.49 6.19 0.32 1.77e-9 Developmental language disorder (linguistic errors); LUSC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg02782426 chr3:40428986 ENTPD3 0.38 7.41 0.38 1.05e-12 Renal cell carcinoma; LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg08888203 chr3:10149979 C3orf24 0.59 8.11 0.41 9.88e-15 Alzheimer's disease; LUSC cis rs7582180 0.629 rs11123826 chr2:100936276 G/T cg12002119 chr2:101014098 CHST10 -0.34 -5.71 -0.3 2.44e-8 Intelligence (multi-trait analysis); LUSC cis rs9329221 0.618 rs4314693 chr8:10258932 G/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.24 -0.32 1.33e-9 Neuroticism; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg02951883 chr7:2050386 MAD1L1 -0.58 -10.66 -0.5 5.13e-23 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.512 rs6060941 chr20:30367383 C/T cg13852791 chr20:30311386 BCL2L1 0.94 14.73 0.63 3.46e-38 Mean corpuscular hemoglobin; LUSC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg03609598 chr5:56110824 MAP3K1 -0.42 -6.11 -0.32 2.71e-9 Initial pursuit acceleration; LUSC cis rs3741151 0.656 rs10501411 chr11:73292085 A/C cg17517138 chr11:73019481 ARHGEF17 0.89 7.81 0.39 7.39e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9326248 0.581 rs12804122 chr11:116902616 C/G cg20608306 chr11:116969690 SIK3 0.37 6.97 0.36 1.73e-11 Blood protein levels; LUSC cis rs7408868 0.764 rs45504393 chr19:15277010 A/G cg14696996 chr19:15285081 NOTCH3 0.99 9.07 0.44 1.06e-17 Pulse pressure; LUSC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg05347473 chr6:146136440 FBXO30 0.53 8.89 0.44 3.86e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs12190007 0.508 rs7452203 chr6:169741858 C/T cg16388071 chr6:169726476 NA -0.37 -6.07 -0.32 3.48e-9 Obesity-related traits; LUSC trans rs11098499 0.826 rs4472123 chr4:120236630 T/A cg25214090 chr10:38739885 LOC399744 0.42 6.29 0.33 1.02e-9 Corneal astigmatism; LUSC cis rs9457247 0.534 rs933243 chr6:167403873 A/C cg23791538 chr6:167370224 RNASET2 -0.47 -7.84 -0.39 6.19e-14 Crohn's disease; LUSC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg04362960 chr10:104952993 NT5C2 0.58 8.42 0.42 1.15e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4478858 0.746 rs60073066 chr1:31689589 G/A cg00250761 chr1:31883323 NA 0.37 9.4 0.46 8.95e-19 Alcohol dependence; LUSC cis rs10876993 0.893 rs3825078 chr12:58089413 A/T cg18357645 chr12:58087776 OS9 0.59 9.0 0.44 1.73e-17 Celiac disease or Rheumatoid arthritis; LUSC trans rs4650994 0.525 rs4993304 chr1:178535144 A/G cg05059571 chr16:84539110 KIAA1609 -0.47 -8.93 -0.44 2.86e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.0 22.91 0.78 1.74e-70 Prudent dietary pattern; LUSC cis rs9287719 0.967 rs7563816 chr2:10763400 C/T cg00105475 chr2:10696890 NA 0.35 5.92 0.31 7.8e-9 Prostate cancer; LUSC cis rs231513 0.911 rs231515 chr17:41964083 A/G cg26893861 chr17:41843967 DUSP3 -0.51 -6.19 -0.32 1.74e-9 Cognitive function; LUSC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg10319629 chr12:132285459 NA 0.4 6.31 0.33 8.96e-10 Migraine; LUSC cis rs3820928 0.874 rs7594505 chr2:227878562 C/G cg11843606 chr2:227700838 RHBDD1 -0.55 -7.96 -0.4 2.72e-14 Pulmonary function; LUSC cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.05e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs7137392 chr12:34447074 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.32e-18 Morning vs. evening chronotype; LUSC cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg07606381 chr6:8435919 SLC35B3 0.75 12.45 0.56 1.73e-29 Motion sickness; LUSC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.57 0.46 2.42e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg23788917 chr6:8435910 SLC35B3 0.5 7.33 0.37 1.8e-12 Motion sickness; LUSC cis rs11039100 0.850 rs11039164 chr11:5843138 C/T cg13902645 chr11:5959945 NA -0.52 -5.87 -0.31 1.07e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -9.21 -0.45 3.8e-18 Bipolar disorder and schizophrenia; LUSC trans rs35847492 1.000 rs35847492 chr8:9276025 G/C cg27411982 chr8:10470053 RP1L1 0.45 6.28 0.32 1.08e-9 Neuroticism; LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg24846343 chr22:24311635 DDTL 0.77 17.35 0.69 1.61e-48 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg09839279 chr12:125627357 AACS -0.31 -5.69 -0.3 2.71e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg24562669 chr7:97807699 LMTK2 0.34 6.0 0.31 5.27e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs561341 0.609 rs7209493 chr17:30197323 A/G cg13647721 chr17:30228624 UTP6 -0.67 -7.19 -0.37 4.33e-12 Hip circumference adjusted for BMI; LUSC cis rs34779708 0.966 rs12775548 chr10:35479504 G/T cg03585969 chr10:35415529 CREM 0.6 8.86 0.44 4.85e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs62400317 0.859 rs10948205 chr6:45124585 T/C cg20913747 chr6:44695427 NA -0.47 -7.51 -0.38 5.31e-13 Total body bone mineral density; LUSC cis rs13108904 0.870 rs2335855 chr4:1237968 T/C cg05025164 chr4:1340916 KIAA1530 0.41 6.23 0.32 1.41e-9 Obesity-related traits; LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg21782813 chr7:2030301 MAD1L1 0.58 10.31 0.49 8.12e-22 Bipolar disorder and schizophrenia; LUSC cis rs1348850 0.914 rs2364854 chr2:178378452 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 7.41 0.38 1.03e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg16405210 chr4:1374714 KIAA1530 0.72 11.05 0.52 2.04e-24 Obesity-related traits; LUSC cis rs561341 0.609 rs7209493 chr17:30197323 A/G cg00745463 chr17:30367425 LRRC37B 0.64 7.62 0.38 2.72e-13 Hip circumference adjusted for BMI; LUSC cis rs9649213 0.511 rs6950994 chr7:97887872 G/A cg24562669 chr7:97807699 LMTK2 0.39 6.61 0.34 1.49e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -5.8 -0.3 1.5e-8 Developmental language disorder (linguistic errors); LUSC trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg03929089 chr4:120376271 NA -0.5 -7.0 -0.36 1.41e-11 HDL cholesterol; LUSC cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg15839431 chr19:19639596 YJEFN3 -0.58 -6.41 -0.33 5.02e-10 Bipolar disorder; LUSC cis rs11077998 0.844 rs1109123 chr17:80522391 T/C cg10255544 chr17:80519551 FOXK2 0.36 5.8 0.3 1.56e-8 Reticulocyte fraction of red cells; LUSC trans rs7647973 0.667 rs11721148 chr3:49646669 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.63 -0.39 2.43e-13 Menarche (age at onset); LUSC cis rs7647973 0.626 rs1491985 chr3:49739507 G/C cg13072238 chr3:49761600 GMPPB -0.64 -8.14 -0.41 8.05e-15 Menarche (age at onset); LUSC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg26727032 chr16:67993705 SLC12A4 -0.45 -5.89 -0.31 9.66e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4077515 0.870 rs11793497 chr9:139271850 A/G cg14019695 chr9:139328340 INPP5E 0.44 8.29 0.41 2.87e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg18402987 chr7:1209562 NA 0.6 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2224391 0.628 rs2773318 chr6:5258843 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.13 -0.32 2.46e-9 Height; LUSC cis rs6674970 0.933 rs11204772 chr1:151056305 C/T cg11822372 chr1:151115635 SEMA6C 0.55 8.52 0.42 5.48e-16 Childhood ear infection; LUSC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg00310523 chr12:86230176 RASSF9 0.49 9.26 0.45 2.64e-18 Major depressive disorder; LUSC cis rs76793172 1.000 rs77756656 chr19:46320718 C/G cg27118825 chr19:46318748 RSPH6A;SYMPK 0.46 5.66 0.3 3.21e-8 Eosinophil counts; LUSC cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg24642439 chr20:33292090 TP53INP2 0.53 8.04 0.4 1.53e-14 Coronary artery disease; LUSC cis rs1003719 0.715 rs2835649 chr21:38552230 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.68 10.72 0.51 3.01e-23 Eye color traits; LUSC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg18350739 chr11:68623251 NA -0.36 -6.33 -0.33 7.68e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01685246 chr16:30538016 ZNF768 -0.42 -6.19 -0.32 1.81e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10788309 0.967 rs7898398 chr10:85793343 A/G cg18063312 chr5:72740737 NA -0.36 -6.02 -0.31 4.55e-9 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); LUSC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg06481639 chr22:41940642 POLR3H 0.48 5.7 0.3 2.63e-8 Vitiligo; LUSC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC trans rs9944715 1.000 rs11082518 chr18:43842032 G/A cg01718231 chr17:29326311 RNF135 -0.5 -6.95 -0.36 1.97e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg14993813 chr1:46806288 NSUN4 -0.52 -7.2 -0.37 4.05e-12 Menopause (age at onset); LUSC trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21659725 chr3:3221576 CRBN 0.58 8.08 0.4 1.2e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg00033643 chr7:134001901 SLC35B4 0.47 7.3 0.37 2.15e-12 Mean platelet volume; LUSC cis rs9372253 0.843 rs9386895 chr6:110719632 T/A cg19196401 chr6:110721138 DDO -0.46 -8.62 -0.43 2.78e-16 Platelet distribution width; LUSC cis rs6546550 0.935 rs6546551 chr2:70073703 C/T cg02498382 chr2:70120550 SNRNP27 -0.29 -7.04 -0.36 1.08e-11 Prevalent atrial fibrillation; LUSC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg20135002 chr11:47629003 NA -0.5 -7.97 -0.4 2.6e-14 Subjective well-being; LUSC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs6545883 0.894 rs12622458 chr2:61523554 A/C cg15711740 chr2:61764176 XPO1 0.43 6.61 0.34 1.5e-10 Tuberculosis; LUSC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs895636 1.000 rs895636 chr2:45188353 A/G cg19444027 chr12:57145625 PRIM1 -0.53 -6.64 -0.34 1.25e-10 Metabolite levels;Fasting plasma glucose; LUSC cis rs13315871 1.000 rs13076951 chr3:58436703 C/T cg12435725 chr3:58293450 RPP14 -0.7 -6.93 -0.35 2.21e-11 Cholesterol, total; LUSC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg03433033 chr1:76189801 ACADM 0.73 9.58 0.46 2.23e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg06108461 chr20:60628389 TAF4 -0.96 -16.37 -0.67 1.27e-44 Body mass index; LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg03433033 chr1:76189801 ACADM 0.79 13.06 0.58 8.9e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2652834 0.851 rs6494391 chr15:63406785 T/C cg05507819 chr15:63340323 TPM1 0.45 5.75 0.3 2e-8 HDL cholesterol; LUSC cis rs1580019 0.885 rs4580942 chr7:32496435 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.76 11.42 0.53 9.75e-26 Cognitive ability; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg10729496 chr3:10149963 C3orf24 0.56 7.62 0.38 2.62e-13 Alzheimer's disease; LUSC cis rs62400317 0.859 rs72869118 chr6:45064626 T/C cg20913747 chr6:44695427 NA -0.46 -7.45 -0.38 8.3e-13 Total body bone mineral density; LUSC cis rs2455601 0.882 rs11042116 chr11:8928472 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.78 -0.35 5.48e-11 Schizophrenia; LUSC cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.17 0.45 5.15e-18 Motion sickness; LUSC cis rs79911532 0.515 rs117892182 chr7:75805689 C/A cg03592824 chr7:75666768 STYXL1 0.65 6.52 0.34 2.57e-10 Mononucleosis; LUSC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg11965913 chr1:205819406 PM20D1 0.46 6.38 0.33 5.83e-10 Parkinson's disease; LUSC cis rs240764 0.687 rs7754085 chr6:101220806 T/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.29e-9 Neuroticism; LUSC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.63e-10 Life satisfaction; LUSC cis rs7568458 0.660 rs55692129 chr2:85792404 A/T cg23752985 chr2:85803571 VAMP8 0.33 6.46 0.33 3.68e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4595586 0.525 rs12812749 chr12:39363254 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.92 0.31 8.06e-9 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg10729496 chr3:10149963 C3orf24 0.51 6.94 0.35 2.07e-11 Alzheimer's disease; LUSC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.06 -0.48 5.7e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4400599 0.618 rs4845610 chr1:154205428 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.9 -0.31 8.9e-9 Platelet distribution width; LUSC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg15556689 chr8:8085844 FLJ10661 0.66 10.64 0.5 6.05e-23 Mood instability; LUSC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg15595755 chr5:1867978 NA 0.46 8.37 0.42 1.57e-15 Cardiovascular disease risk factors; LUSC cis rs2303282 0.664 rs4238787 chr16:56442066 C/T cg00500540 chr16:56394104 NA -0.39 -6.7 -0.34 8.91e-11 Breast cancer; LUSC cis rs56161922 1.000 rs4562622 chr1:207876577 A/C cg11752769 chr1:207818423 CR1L 0.71 6.07 0.32 3.54e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07639963 chr12:77157760 ZDHHC17 -0.49 -6.13 -0.32 2.54e-9 Bipolar disorder and schizophrenia; LUSC cis rs1003719 0.688 rs2835662 chr21:38568967 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg04944784 chr2:26401820 FAM59B -0.68 -9.69 -0.47 9.62e-20 Gut microbiome composition (summer); LUSC trans rs6126344 0.957 rs1018422 chr20:50404452 C/T cg03643032 chr16:85954903 IRF8 0.3 6.06 0.31 3.63e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs727505 0.607 rs66478705 chr7:124789211 C/G cg23710748 chr7:124431027 NA -0.4 -6.92 -0.35 2.31e-11 Lewy body disease; LUSC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg23630131 chr7:65973040 NA -0.21 -5.8 -0.3 1.55e-8 Aortic root size; LUSC cis rs9534288 0.783 rs7987385 chr13:46634131 A/G cg15192986 chr13:46630673 CPB2 -0.8 -12.65 -0.57 3.2e-30 Blood protein levels; LUSC cis rs1018836 0.923 rs12680211 chr8:91633434 C/T cg16814680 chr8:91681699 NA -0.76 -12.55 -0.57 7.19e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg22823121 chr1:150693482 HORMAD1 0.5 7.18 0.37 4.54e-12 Melanoma; LUSC cis rs8060686 0.641 rs55725810 chr16:68189636 C/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2289583 0.544 rs6495132 chr15:75255322 C/T cg14664628 chr15:75095509 CSK 0.47 6.49 0.33 3.07e-10 Systemic lupus erythematosus; LUSC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.79e-8 Depression; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.45 0.33 3.86e-10 Menopause (age at onset); LUSC cis rs11048434 0.723 rs2080117 chr12:9138341 C/T cg13575925 chr12:9217583 LOC144571 0.34 6.28 0.32 1.07e-9 Sjögren's syndrome; LUSC cis rs9640161 0.711 rs3735170 chr7:150034184 T/C cg10018233 chr7:150070692 REPIN1 0.4 6.68 0.34 9.91e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg05896524 chr21:47604654 C21orf56 -0.59 -9.37 -0.46 1.08e-18 Testicular germ cell tumor; LUSC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg10909506 chr17:38081995 ORMDL3 0.34 6.11 0.32 2.71e-9 Self-reported allergy; LUSC cis rs1256061 0.603 rs1269056 chr14:64743890 T/C cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.18e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs9503598 0.636 rs6596978 chr6:3468878 C/T cg05722439 chr19:14072965 RFX1 -0.3 -6.03 -0.31 4.43e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.03 -0.31 4.28e-9 Platelet count; LUSC cis rs3820928 0.967 rs12622456 chr2:227768868 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.8e-14 Pulmonary function; LUSC cis rs7586879 0.639 rs7567997 chr2:25096952 A/G cg15423357 chr2:25149977 NA 0.38 7.57 0.38 3.62e-13 Body mass index; LUSC cis rs10779751 0.690 rs2791659 chr1:11126569 C/A cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08682991 chr16:70557429 COG4;SF3B3 0.78 6.23 0.32 1.44e-9 Cognitive performance; LUSC cis rs7824557 0.836 rs2736378 chr8:11119760 G/A cg21775007 chr8:11205619 TDH -0.59 -9.25 -0.45 2.83e-18 Retinal vascular caliber; LUSC trans rs7824557 0.564 rs11782430 chr8:11226071 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.19 -0.45 4.26e-18 Retinal vascular caliber; LUSC cis rs11758351 0.866 rs77889957 chr6:26207435 A/G cg23601095 chr6:26197514 HIST1H3D 0.68 7.51 0.38 5.59e-13 Gout;Renal underexcretion gout; LUSC cis rs9329221 1.000 rs9329221 chr8:10240202 G/T cg21775007 chr8:11205619 TDH 0.47 6.95 0.36 1.9e-11 Neuroticism; LUSC trans rs17685 0.712 rs7778735 chr7:75770237 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1729951 0.575 rs12494558 chr3:136678781 C/G cg12473912 chr3:136751656 NA 0.39 6.74 0.35 6.82e-11 Neuroticism; LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg21724239 chr8:58056113 NA 0.76 8.31 0.41 2.37e-15 Developmental language disorder (linguistic errors); LUSC cis rs9486719 1.000 rs12213426 chr6:96896035 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Migraine;Coronary artery disease; LUSC cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg09526685 chr4:187126073 CYP4V2 0.62 5.99 0.31 5.41e-9 Blood protein levels; LUSC cis rs6500395 0.962 rs9941336 chr16:48652769 G/A cg04672837 chr16:48644449 N4BP1 0.47 6.73 0.35 7.28e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2067615 0.542 rs4346064 chr12:107081599 C/A cg15890332 chr12:107067104 RFX4 0.35 6.27 0.32 1.08e-9 Heart rate; LUSC cis rs6693567 0.507 rs863862 chr1:150352361 T/A cg15654264 chr1:150340011 RPRD2 0.46 7.35 0.37 1.5e-12 Migraine; LUSC cis rs2425143 1.000 rs7267759 chr20:34257284 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -6.56 -0.34 2.09e-10 Blood protein levels; LUSC cis rs10769945 0.679 rs217213 chr11:1979118 C/G cg23202291 chr11:1979235 NA -0.42 -6.74 -0.35 7.07e-11 DNA methylation (variation); LUSC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs72634258 0.945 rs225132 chr1:8095500 A/C cg26816564 chr1:7831052 VAMP3 0.5 6.52 0.34 2.64e-10 Inflammatory bowel disease; LUSC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.44 0.53 8.49e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs62400317 0.859 rs12201005 chr6:45136922 A/T cg18551225 chr6:44695536 NA -0.42 -6.84 -0.35 3.81e-11 Total body bone mineral density; LUSC cis rs4356932 0.967 rs4386624 chr4:76946139 G/C cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -11.68 -0.54 1.17e-26 Chronic sinus infection; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg11494091 chr17:61959527 GH2 -0.63 -13.37 -0.59 5.78e-33 Prudent dietary pattern; LUSC cis rs6500602 0.702 rs9929475 chr16:4540885 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.46 -6.08 -0.32 3.2e-9 Schizophrenia; LUSC cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg17063962 chr7:91808500 NA 0.59 9.28 0.45 2.19e-18 Breast cancer; LUSC cis rs12973672 1.000 rs34832786 chr19:35769518 T/C cg12095397 chr19:35769544 USF2 0.44 6.91 0.35 2.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg14844989 chr11:31128820 NA -0.37 -5.85 -0.3 1.18e-8 Red blood cell count; LUSC cis rs3755132 0.929 rs2302931 chr2:15737480 C/A cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.68e-12 Wilms tumor; LUSC cis rs11190604 1.000 rs7079136 chr10:102292709 T/C cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7584330 0.737 rs10445707 chr2:238368751 A/G cg14458575 chr2:238380390 NA 0.65 11.53 0.53 3.96e-26 Prostate cancer; LUSC cis rs4589502 1.000 rs80263963 chr15:67127228 C/T cg09911534 chr15:67153556 NA -0.64 -6.55 -0.34 2.16e-10 Lung cancer (smoking interaction); LUSC cis rs6696846 0.715 rs61822659 chr1:205142847 G/A cg00857998 chr1:205179979 DSTYK 0.66 10.29 0.49 9.24e-22 Red blood cell count; LUSC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg22508957 chr16:3507546 NAT15 -0.61 -9.83 -0.47 3.31e-20 Tuberculosis; LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg05025164 chr4:1340916 KIAA1530 0.41 6.11 0.32 2.8e-9 Obesity-related traits; LUSC cis rs11155671 0.530 rs9397398 chr6:150193603 G/A cg04369109 chr6:150039330 LATS1 -0.43 -6.17 -0.32 1.97e-9 Testicular germ cell tumor; LUSC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg23281280 chr6:28129359 ZNF389 0.45 5.7 0.3 2.65e-8 Depression; LUSC cis rs17155006 0.561 rs22783 chr7:107743243 G/T cg05962710 chr7:107745446 LAMB4 -0.34 -6.1 -0.32 2.87e-9 Pneumococcal bacteremia; LUSC cis rs6500602 0.727 rs11076837 chr16:4569440 C/T cg08645402 chr16:4508243 NA 0.52 8.78 0.43 8.49e-17 Schizophrenia; LUSC cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg07828340 chr4:882639 GAK -0.96 -10.94 -0.51 5.03e-24 Intelligence (multi-trait analysis); LUSC cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg00012203 chr2:219082015 ARPC2 -0.82 -15.34 -0.64 1.4e-40 Colorectal cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00670742 chr2:87034831 CD8A 0.74 6.06 0.31 3.63e-9 Cognitive performance; LUSC cis rs12594515 0.967 rs11854477 chr15:45998345 A/C cg19682013 chr15:45996608 NA 0.38 5.72 0.3 2.31e-8 Waist circumference;Weight; LUSC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg13126279 chr21:47581558 C21orf56 0.47 7.05 0.36 1e-11 Testicular germ cell tumor; LUSC cis rs10489202 1.000 rs3767474 chr1:168062398 C/T cg24449463 chr1:168025552 DCAF6 -0.57 -7.03 -0.36 1.17e-11 Schizophrenia; LUSC cis rs3820928 0.874 rs10189579 chr2:227864876 A/G cg11843606 chr2:227700838 RHBDD1 -0.51 -7.31 -0.37 1.99e-12 Pulmonary function; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26401236 chr17:19881329 AKAP10 -0.49 -6.62 -0.34 1.46e-10 Hepatitis; LUSC trans rs11039798 0.511 rs7948129 chr11:48167828 G/A cg15704280 chr7:45808275 SEPT13 -0.64 -7.08 -0.36 8.44e-12 Axial length; LUSC cis rs2486288 0.656 rs6493144 chr15:45573489 C/G cg26924012 chr15:45694286 SPATA5L1 0.75 11.26 0.52 3.73e-25 Glomerular filtration rate; LUSC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg20608306 chr11:116969690 SIK3 0.4 6.68 0.34 9.91e-11 Blood protein levels; LUSC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg18240062 chr17:79603768 NPLOC4 0.63 11.19 0.52 6.63e-25 Eye color traits; LUSC cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg23788917 chr6:8435910 SLC35B3 0.51 7.5 0.38 5.8e-13 Motion sickness; LUSC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.67 -0.39 1.88e-13 Height; LUSC cis rs8099014 0.859 rs11152072 chr18:56098912 A/G cg12907477 chr18:56117327 MIR122 0.46 6.95 0.36 1.91e-11 Platelet count; LUSC cis rs793571 0.714 rs972801 chr15:58921198 C/T cg05156742 chr15:59063176 FAM63B -0.53 -7.62 -0.38 2.64e-13 Schizophrenia; LUSC cis rs174601 0.861 rs174584 chr11:61610750 G/A cg19610905 chr11:61596333 FADS2 -0.51 -7.72 -0.39 1.39e-13 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC cis rs12410462 0.681 rs12401677 chr1:227608577 T/C cg23173402 chr1:227635558 NA 0.69 7.52 0.38 5.16e-13 Major depressive disorder; LUSC cis rs7903847 0.642 rs1048442 chr10:99160152 A/G cg08345082 chr10:99160200 RRP12 -0.32 -6.67 -0.34 1.08e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs2439831 0.681 rs540388 chr15:43606494 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.66 0.65 7.7e-42 Lung cancer in ever smokers; LUSC cis rs2274273 0.624 rs66464079 chr14:55766164 G/T cg04306507 chr14:55594613 LGALS3 0.49 9.89 0.48 2.21e-20 Protein biomarker; LUSC cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg24642439 chr20:33292090 TP53INP2 -0.48 -7.39 -0.37 1.2e-12 Glomerular filtration rate (creatinine); LUSC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg21138405 chr5:131827807 IRF1 -0.57 -11.37 -0.53 1.53e-25 Asthma (sex interaction); LUSC cis rs1997103 0.954 rs940880 chr7:55392619 C/G cg17469321 chr7:55412551 NA 0.68 10.97 0.51 4.06e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs13315871 1.000 rs13315871 chr3:58381287 G/A cg20936604 chr3:58311152 NA -0.65 -6.09 -0.32 3.05e-9 Cholesterol, total; LUSC cis rs76878669 0.561 rs11227465 chr11:66115879 T/A cg18002602 chr11:66138449 SLC29A2 -0.48 -8.37 -0.42 1.55e-15 Educational attainment (years of education); LUSC trans rs60843830 1.000 rs60149603 chr2:285421 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 10.69 0.5 3.8e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7586879 0.765 rs11683429 chr2:25120733 T/A cg15423357 chr2:25149977 NA 0.32 5.77 0.3 1.8e-8 Body mass index; LUSC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg00409905 chr10:38381863 ZNF37A -0.36 -6.21 -0.32 1.57e-9 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.59 0.43 3.36e-16 Prudent dietary pattern; LUSC cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg12011299 chr4:100065546 ADH4 0.61 9.71 0.47 8.65e-20 Alcohol dependence; LUSC cis rs55665837 1.000 rs10047457 chr11:14439459 T/A cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg21880101 chr17:80066754 CCDC57 -0.31 -5.8 -0.3 1.54e-8 Life satisfaction; LUSC cis rs950027 0.620 rs2461700 chr15:45640627 T/C cg21132104 chr15:45694354 SPATA5L1 0.41 6.09 0.32 3.08e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg07936489 chr17:37558343 FBXL20 -0.7 -9.69 -0.47 1.01e-19 Glomerular filtration rate (creatinine); LUSC cis rs2292884 0.505 rs77856818 chr2:238402830 G/A cg14458575 chr2:238380390 NA 0.7 8.06 0.4 1.34e-14 Prostate cancer; LUSC cis rs1044826 0.642 rs407958 chr3:139213632 T/C cg15131784 chr3:139108705 COPB2 0.39 6.36 0.33 6.82e-10 Obesity-related traits; LUSC cis rs1371867 0.846 rs1788191 chr8:101260844 C/T cg00191853 chr8:101177733 SPAG1 0.36 5.81 0.3 1.42e-8 Atrioventricular conduction; LUSC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg14552801 chr7:65878734 NA 0.44 6.27 0.32 1.12e-9 Aortic root size; LUSC cis rs1506636 0.539 rs17701547 chr7:123383461 A/G cg03229431 chr7:123269106 ASB15 -0.53 -7.22 -0.37 3.55e-12 Plateletcrit;Platelet count; LUSC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg24675056 chr1:15929824 NA 0.45 7.85 0.39 5.81e-14 Systolic blood pressure; LUSC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.4 0.53 1.21e-25 Colorectal cancer; LUSC cis rs763121 0.853 rs2413545 chr22:39092524 C/T cg06022373 chr22:39101656 GTPBP1 0.81 12.6 0.57 4.67e-30 Menopause (age at onset); LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg23835219 chr4:1244017 CTBP1;C4orf42 0.3 5.65 0.3 3.51e-8 Obesity-related traits; LUSC cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -8.99 -0.44 1.89e-17 Bone mineral density; LUSC cis rs16949788 0.793 rs12439706 chr15:66668004 C/T cg08120210 chr15:66682733 MAP2K1 -0.58 -5.82 -0.3 1.41e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg04972856 chr6:88032051 C6orf162;GJB7 0.49 9.33 0.45 1.55e-18 Monocyte percentage of white cells; LUSC cis rs11229555 0.645 rs12289985 chr11:58185436 C/G cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs2587949 0.615 rs1872414 chr3:4234154 T/C cg15139668 chr4:4577005 NA 0.4 6.01 0.31 4.8e-9 Periodontitis (DPAL); LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg22920501 chr2:26401640 FAM59B -0.79 -11.76 -0.54 5.97e-27 Gut microbiome composition (summer); LUSC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.28 0.49 1.04e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg08917208 chr2:24149416 ATAD2B 0.51 5.76 0.3 1.88e-8 Lymphocyte counts; LUSC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg03609598 chr5:56110824 MAP3K1 -0.43 -6.23 -0.32 1.44e-9 Initial pursuit acceleration; LUSC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg20891558 chr2:74357851 NA 0.78 13.05 0.58 9.37e-32 Gestational age at birth (maternal effect); LUSC cis rs6500602 0.647 rs4786501 chr16:4536165 G/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.5 -6.77 -0.35 5.68e-11 Schizophrenia; LUSC trans rs62103177 0.608 rs613847 chr18:77845644 A/G cg05926928 chr17:57297772 GDPD1 -0.9 -10.32 -0.49 7.2e-22 Opioid sensitivity; LUSC cis rs963731 0.649 rs2278912 chr2:39199702 C/T cg04010122 chr2:39346883 SOS1 -0.8 -5.84 -0.3 1.21e-8 Corticobasal degeneration; LUSC cis rs877282 0.945 rs71489301 chr10:770191 A/G cg17470449 chr10:769945 NA 0.53 7.48 0.38 6.8e-13 Uric acid levels; LUSC cis rs2502731 0.561 rs3003606 chr9:130982416 C/T cg09976142 chr9:130955436 CIZ1 0.47 7.86 0.39 5.49e-14 Attention deficit hyperactivity disorder; LUSC cis rs273573 0.816 rs605083 chr11:30853147 C/G cg14844989 chr11:31128820 NA 0.36 5.74 0.3 2.18e-8 Total body bone mineral density; LUSC cis rs2075671 0.903 rs11760602 chr7:100264128 G/C cg20848291 chr7:100343083 ZAN -0.65 -8.69 -0.43 1.6e-16 Other erythrocyte phenotypes; LUSC cis rs62400317 0.762 rs72865924 chr6:44878943 G/A cg18551225 chr6:44695536 NA -0.46 -7.44 -0.38 8.7e-13 Total body bone mineral density; LUSC cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.76e-11 Intelligence (multi-trait analysis); LUSC cis rs3845702 0.736 rs115569960 chr2:180848214 C/T cg01881094 chr2:180872142 CWC22 1.06 12.72 0.57 1.69e-30 Schizophrenia; LUSC cis rs897080 0.515 rs1067404 chr2:44675823 G/T cg00619915 chr2:44497795 NA 0.42 6.01 0.31 4.83e-9 Height; LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11992162 1.000 rs7460395 chr8:11835375 C/T cg21775007 chr8:11205619 TDH 0.5 6.85 0.35 3.54e-11 Monocyte count; LUSC cis rs28830936 0.966 rs17678552 chr15:42066190 T/C cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.27 -0.32 1.14e-9 Diastolic blood pressure; LUSC cis rs2227564 0.678 rs2242256 chr10:75597546 C/G cg23231163 chr10:75533350 FUT11 0.42 5.79 0.3 1.66e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs61931739 0.534 rs11053029 chr12:34131766 G/T cg06521331 chr12:34319734 NA -0.48 -7.85 -0.39 5.8e-14 Morning vs. evening chronotype; LUSC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg23158103 chr7:148848205 ZNF398 -0.46 -7.49 -0.38 6.07e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6499755 0.932 rs9302665 chr16:55340567 C/G cg02859129 chr16:55357253 IRX6 -0.37 -6.17 -0.32 1.98e-9 Hypospadias; LUSC cis rs921665 0.831 rs7596478 chr2:3176358 A/G cg02624386 chr2:3182749 NA 0.57 6.44 0.33 4.26e-10 World class endurance athleticism; LUSC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg17385448 chr1:15911702 AGMAT 0.37 6.4 0.33 5.32e-10 Systolic blood pressure; LUSC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg12963246 chr6:28129442 ZNF389 0.38 5.74 0.3 2.09e-8 Cardiac Troponin-T levels; LUSC cis rs7191700 0.511 rs8058983 chr16:11360849 A/G cg00044050 chr16:11439710 C16orf75 -0.7 -12.45 -0.56 1.77e-29 Multiple sclerosis; LUSC cis rs7666738 0.512 rs6532704 chr4:98777562 C/T cg05340658 chr4:99064831 C4orf37 0.45 7.08 0.36 8.69e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg15212455 chr7:39170539 POU6F2 0.62 10.0 0.48 8.88e-21 IgG glycosylation; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg06873352 chr17:61820015 STRADA 0.71 12.58 0.57 5.56e-30 Prudent dietary pattern; LUSC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.04 -0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs2637266 0.967 rs4979898 chr10:78355672 G/A cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs8072100 0.582 rs3826536 chr17:45501967 T/A cg08085267 chr17:45401833 C17orf57 -0.51 -7.29 -0.37 2.22e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg00750074 chr16:89608354 SPG7 -0.57 -10.08 -0.48 4.76e-21 Multiple myeloma (IgH translocation); LUSC cis rs6580649 1.000 rs3825404 chr12:48399931 A/G cg24011408 chr12:48396354 COL2A1 0.56 7.59 0.38 3.21e-13 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07150314 chr2:27579984 GTF3C2 -0.42 -6.47 -0.33 3.55e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg01579765 chr21:45077557 HSF2BP -0.45 -9.51 -0.46 3.98e-19 Mean corpuscular volume; LUSC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs7647973 0.710 rs6797299 chr3:49609794 G/T cg03060546 chr3:49711283 APEH 0.64 6.96 0.36 1.76e-11 Menarche (age at onset); LUSC trans rs12310956 0.532 rs1525903 chr12:33964163 T/C cg13010199 chr12:38710504 ALG10B 0.52 7.81 0.39 7.56e-14 Morning vs. evening chronotype; LUSC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg04025307 chr7:1156635 C7orf50 0.44 6.07 0.32 3.56e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg18765753 chr7:1198926 ZFAND2A -0.39 -6.88 -0.35 2.99e-11 Longevity;Endometriosis; LUSC cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.51 -7.67 -0.39 1.9e-13 Menarche (age at onset); LUSC trans rs11722228 0.549 rs3796818 chr4:10097976 C/T cg26043149 chr18:55253948 FECH 0.98 14.93 0.63 5.84e-39 Gout;Urate levels;Serum uric acid levels; LUSC cis rs9467773 0.967 rs9461267 chr6:26525455 T/G cg05738196 chr6:26577821 NA 0.81 15.71 0.65 4.89e-42 Intelligence (multi-trait analysis); LUSC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg20203395 chr5:56204925 C5orf35 -0.46 -7.01 -0.36 1.3e-11 Breast cancer;Breast cancer (early onset); LUSC trans rs61931739 0.534 rs4001713 chr12:34154195 A/C cg26384229 chr12:38710491 ALG10B -0.7 -11.03 -0.52 2.42e-24 Morning vs. evening chronotype; LUSC cis rs10197940 0.578 rs2432957 chr2:152287897 A/C cg19508488 chr2:152266495 RIF1 0.39 5.77 0.3 1.77e-8 Lung cancer; LUSC cis rs6121246 0.529 rs6060210 chr20:30187681 C/T cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs7799006 0.606 rs34417375 chr7:2315105 C/T cg12823233 chr7:2316876 SNX8 -0.45 -7.58 -0.38 3.49e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.48 5.84 0.3 1.22e-8 Schizophrenia; LUSC cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg16850897 chr7:100343110 ZAN 0.6 8.41 0.42 1.19e-15 Other erythrocyte phenotypes; LUSC cis rs9677476 0.774 rs1973016 chr2:232117513 C/G cg07929768 chr2:232055508 NA 0.33 6.1 0.32 2.87e-9 Food antigen IgG levels; LUSC trans rs62238980 0.614 rs17682583 chr22:32401495 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg01879757 chr17:41196368 BRCA1 -0.5 -7.79 -0.39 8.44e-14 Menopause (age at onset); LUSC cis rs11779988 0.545 rs448882 chr8:17794039 C/T cg01800426 chr8:17659068 MTUS1 -0.5 -5.97 -0.31 5.95e-9 Breast cancer; LUSC cis rs1395 0.744 rs1975384 chr2:27542041 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.44 6.19 0.32 1.78e-9 Blood metabolite levels; LUSC cis rs6121246 0.909 rs6058463 chr20:30385192 C/T cg18721089 chr20:30220636 NA -0.35 -6.01 -0.31 4.98e-9 Mean corpuscular hemoglobin; LUSC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg09021430 chr5:549028 NA -0.56 -7.57 -0.38 3.61e-13 Obesity-related traits; LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg19266014 chr7:2183958 MAD1L1 -0.34 -5.68 -0.3 2.97e-8 Bipolar disorder and schizophrenia; LUSC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.51 7.88 0.4 4.61e-14 Menarche (age at onset); LUSC cis rs1881797 0.527 rs1852908 chr1:247678260 C/T cg14830002 chr1:247616686 OR2B11 0.64 7.25 0.37 2.89e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs10504229 0.516 rs4361758 chr8:57990401 C/T cg11062466 chr8:58055876 NA 0.39 5.79 0.3 1.58e-8 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg19318889 chr4:1322082 MAEA 0.45 7.41 0.38 1.06e-12 Obesity-related traits; LUSC cis rs3849570 1.000 rs2290081 chr3:81810725 C/T cg07356753 chr3:81810745 GBE1 -0.67 -10.87 -0.51 9.3e-24 Waist circumference;Body mass index; LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.92e-21 Monocyte count; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg08219700 chr8:58056026 NA 0.68 8.62 0.43 2.75e-16 Developmental language disorder (linguistic errors); LUSC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg24642439 chr20:33292090 TP53INP2 -0.56 -8.51 -0.42 5.89e-16 Height; LUSC cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg25208724 chr1:156163844 SLC25A44 1.05 18.06 0.7 2.28e-51 Testicular germ cell tumor; LUSC cis rs2635047 0.934 rs11663321 chr18:44622704 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.47 7.34 0.37 1.61e-12 Educational attainment; LUSC cis rs1577917 0.740 rs2475792 chr6:86392102 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 7.65 0.39 2.21e-13 Response to antipsychotic treatment; LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg13560548 chr3:10150139 C3orf24 -0.54 -6.62 -0.34 1.45e-10 Alzheimer's disease; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg03579872 chr1:53393473 SCP2 -0.38 -5.71 -0.3 2.54e-8 Monocyte count; LUSC cis rs4253772 0.938 rs45550937 chr22:46638128 C/G cg24881330 chr22:46731750 TRMU 0.63 5.85 0.31 1.15e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs7572733 0.534 rs4850815 chr2:198786167 G/T cg00792783 chr2:198669748 PLCL1 -0.44 -5.96 -0.31 6.57e-9 Dermatomyositis; LUSC cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14442939 chr10:27389572 ANKRD26 -0.88 -9.89 -0.48 2.06e-20 Breast cancer; LUSC cis rs10992471 0.603 rs10116813 chr9:95090360 C/T cg14631576 chr9:95140430 CENPP -0.37 -6.23 -0.32 1.37e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg12016809 chr21:47604291 C21orf56 -0.47 -7.02 -0.36 1.22e-11 Testicular germ cell tumor; LUSC cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg04586622 chr2:25135609 ADCY3 0.32 6.18 0.32 1.92e-9 Body mass index; LUSC trans rs853679 0.607 rs34396849 chr6:28250955 A/C cg06606381 chr12:133084897 FBRSL1 -0.95 -9.13 -0.45 6.49e-18 Depression; LUSC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg04450456 chr4:17643702 FAM184B 0.4 6.94 0.35 2.1e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs763121 0.925 rs9835 chr22:39130971 A/G cg06544989 chr22:39130855 UNC84B 0.32 5.75 0.3 2e-8 Menopause (age at onset); LUSC cis rs7582180 0.681 rs6754176 chr2:100995691 C/T cg12002119 chr2:101014098 CHST10 0.35 5.88 0.31 9.71e-9 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.602 rs1727296 chr12:123647725 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.17 -0.32 1.95e-9 Neutrophil percentage of white cells; LUSC cis rs6901250 0.569 rs594940 chr6:117090358 C/T cg12892004 chr6:117198278 RFX6 0.37 6.68 0.34 9.97e-11 C-reactive protein levels; LUSC cis rs17401966 0.931 rs912961 chr1:10356848 A/G cg19773385 chr1:10388646 KIF1B -0.59 -10.01 -0.48 8.62e-21 Hepatocellular carcinoma; LUSC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg25809561 chr17:30822961 MYO1D 0.57 9.69 0.47 9.59e-20 Schizophrenia; LUSC cis rs10465746 0.780 rs7529293 chr1:84331981 A/G cg10977910 chr1:84465055 TTLL7 0.45 6.44 0.33 4.26e-10 Obesity-related traits; LUSC cis rs11169225 0.906 rs3782319 chr12:50345079 G/A cg04450003 chr12:50355995 AQP5 0.78 13.3 0.59 1.11e-32 Allergic disease (asthma, hay fever or eczema); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04110109 chr17:39968849 FKBP10;SC65 0.46 6.58 0.34 1.79e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1185460 0.967 rs1177562 chr11:118949331 C/T cg23280166 chr11:118938394 VPS11 0.48 7.33 0.37 1.76e-12 Coronary artery disease; LUSC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg22907277 chr7:1156413 C7orf50 0.71 10.28 0.49 1.04e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg06850241 chr22:41845214 NA 0.34 6.3 0.33 9.5e-10 Vitiligo; LUSC cis rs6582630 0.638 rs12831496 chr12:38552604 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.43 -0.33 4.41e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2708977 0.637 rs597420 chr2:97070353 T/C cg01950434 chr2:97203154 ARID5A -0.45 -6.18 -0.32 1.89e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg12463550 chr7:65579703 CRCP -0.47 -7.1 -0.36 7.36e-12 Aortic root size; LUSC trans rs1493916 0.905 rs1586988 chr18:31396001 G/C cg13755796 chr4:20253514 NA -0.44 -6.9 -0.35 2.56e-11 Life satisfaction; LUSC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg11764359 chr7:65958608 NA -0.79 -13.07 -0.58 8.16e-32 Aortic root size; LUSC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg10018233 chr7:150070692 REPIN1 0.38 6.73 0.35 7.52e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs847577 0.588 rs12666406 chr7:97790991 G/A cg24562669 chr7:97807699 LMTK2 0.48 8.76 0.43 1e-16 Breast cancer; LUSC cis rs4704187 0.687 rs6894048 chr5:74456838 A/G cg03227963 chr5:74354835 NA 0.31 6.8 0.35 4.74e-11 Response to amphetamines; LUSC cis rs6723226 0.803 rs387780 chr2:32502495 T/C cg02381751 chr2:32503542 YIPF4 0.65 9.7 0.47 9.32e-20 Intelligence (multi-trait analysis); LUSC cis rs11051970 0.918 rs1055876 chr12:32536200 C/T cg24626660 chr12:32551988 NA 0.38 6.14 0.32 2.31e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg01341218 chr17:43662625 NA 0.77 11.31 0.53 2.49e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20491397 chr13:22177926 EFHA1 -0.42 -6.25 -0.32 1.23e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17255340 0.539 rs1144192 chr6:83980929 C/G cg08257003 chr6:84140564 ME1 0.32 7.7 0.39 1.52e-13 Platelet-derived growth factor BB levels; LUSC cis rs11676348 0.755 rs62183956 chr2:219046122 C/T cg23569941 chr2:219139048 TMBIM1;PNKD -0.36 -6.01 -0.31 4.85e-9 Ulcerative colitis; LUSC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.43 -6.23 -0.32 1.4e-9 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26272893 chr1:41445793 CTPS -0.42 -6.23 -0.32 1.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.45 -0.42 9.43e-16 Lung cancer; LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg19318889 chr4:1322082 MAEA -0.54 -8.8 -0.43 7.42e-17 Obesity-related traits; LUSC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg23093090 chr10:104574429 C10orf26 -0.46 -8.04 -0.4 1.52e-14 Arsenic metabolism; LUSC cis rs2573652 1.000 rs2727198 chr15:100513722 T/C cg09918751 chr15:100517450 ADAMTS17 -0.42 -7.7 -0.39 1.52e-13 Height; LUSC cis rs3020736 0.500 rs6002616 chr22:42504679 A/G cg15557168 chr22:42548783 NA 0.48 7.39 0.38 1.16e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg00745463 chr17:30367425 LRRC37B -0.74 -8.49 -0.42 6.8e-16 Hip circumference adjusted for BMI; LUSC cis rs8062405 0.824 rs4788084 chr16:28539848 C/T cg16576597 chr16:28551801 NUPR1 0.29 5.75 0.3 2.01e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 6.02 0.31 4.59e-9 Tonsillectomy; LUSC trans rs11764590 0.585 rs11772463 chr7:2078132 A/C cg10840412 chr1:235813424 GNG4 0.53 6.33 0.33 8.1e-10 Neuroticism; LUSC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg25204440 chr1:209979598 IRF6 0.53 6.95 0.36 1.98e-11 Cleft lip with or without cleft palate; LUSC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.62e-24 Aortic root size; LUSC cis rs1775715 0.737 rs2151047 chr10:32102110 G/A cg26784012 chr10:32216390 ARHGAP12 0.46 7.67 0.39 1.89e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11890956 chr21:40555474 PSMG1 1.03 20.82 0.75 2.6e-62 Cognitive function; LUSC cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg11530693 chr1:120165357 ZNF697 0.69 10.78 0.51 1.91e-23 Systemic lupus erythematosus; LUSC cis rs702885 0.510 rs1641463 chr2:65782300 G/A cg05136724 chr2:65793962 NA -0.53 -5.75 -0.3 2.05e-8 Electroencephalogram traits; LUSC cis rs11077998 0.967 rs12185229 chr17:80499065 G/C cg10255544 chr17:80519551 FOXK2 0.41 6.73 0.35 7.32e-11 Reticulocyte fraction of red cells; LUSC cis rs8114671 0.967 rs6142322 chr20:33788538 C/A cg24642439 chr20:33292090 TP53INP2 -0.4 -5.81 -0.3 1.45e-8 Height; LUSC cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg19628046 chr18:33552617 C18orf21 0.5 6.25 0.32 1.26e-9 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27636011 chr10:102746998 C10orf2;MRPL43 0.45 6.03 0.31 4.23e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10100465 0.961 rs13439042 chr8:118634613 A/T cg09430518 chr8:118662568 NA 0.3 5.82 0.3 1.4e-8 Leprosy; LUSC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg12463550 chr7:65579703 CRCP -0.51 -7.33 -0.37 1.74e-12 Aortic root size; LUSC cis rs2439831 0.867 rs2584702 chr15:43684914 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.91 9.73 0.47 7.58e-20 Lung cancer in ever smokers; LUSC cis rs886126 1.000 rs10774616 chr12:111662885 G/T cg10833066 chr12:111807467 FAM109A 0.4 6.29 0.33 9.97e-10 Coronary heart disease; LUSC cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.03 -0.4 1.66e-14 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg14993813 chr1:46806288 NSUN4 -0.5 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg15445000 chr17:37608096 MED1 -0.38 -6.67 -0.34 1.06e-10 Glomerular filtration rate (creatinine); LUSC cis rs3892630 0.824 rs7247264 chr19:33239846 T/G cg22980127 chr19:33182716 NUDT19 0.91 12.49 0.56 1.25e-29 Red blood cell traits; LUSC cis rs662064 0.962 rs620405 chr1:10554794 T/C cg17425144 chr1:10567563 PEX14 0.36 5.68 0.3 3e-8 Asthma; LUSC cis rs4595586 0.545 rs1303886 chr12:39366876 G/A cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs908922 0.636 rs474086 chr1:152513431 C/T cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24777315 chr12:66135734 NA -0.45 -6.09 -0.32 3.1e-9 Bipolar disorder and schizophrenia; LUSC trans rs11700980 0.551 rs12481736 chr21:30113657 A/G cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs12210905 0.843 rs12208039 chr6:26984004 C/A cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs6121246 0.567 rs6060247 chr20:30190720 C/G cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.64e-15 Mean corpuscular hemoglobin; LUSC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg02931644 chr1:25747376 RHCE 0.37 6.82 0.35 4.41e-11 Erythrocyte sedimentation rate; LUSC cis rs12950390 0.853 rs56387656 chr17:45860189 C/G cg06532163 chr17:45867833 NA 0.35 6.53 0.34 2.45e-10 IgG glycosylation; LUSC cis rs958025 1 rs958025 chr15:78759348 C/T cg24631222 chr15:78858424 CHRNA5 0.66 8.75 0.43 1.09e-16 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11711311 0.911 rs9831422 chr3:113398195 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.22 0.32 1.45e-9 IgG glycosylation; LUSC cis rs713587 0.525 rs11687089 chr2:25082926 T/C cg15423357 chr2:25149977 NA 0.34 6.45 0.33 3.96e-10 Body mass index in non-asthmatics; LUSC cis rs11785400 0.890 rs13279182 chr8:143720544 A/G cg24634471 chr8:143751801 JRK 0.57 8.43 0.42 1.03e-15 Schizophrenia; LUSC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs4363385 0.510 rs7531076 chr1:153039167 G/T cg25856811 chr1:152973957 SPRR3 -0.37 -6.17 -0.32 1.99e-9 Inflammatory skin disease; LUSC cis rs7131987 0.903 rs2194519 chr12:29423583 C/T cg09582351 chr12:29534625 ERGIC2 0.32 6.64 0.34 1.25e-10 QT interval; LUSC cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.13 0.66 1.09e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs1691799 0.899 rs1168327 chr12:66728842 G/A cg16791601 chr12:66731901 HELB -0.71 -12.4 -0.56 2.68e-29 White blood cell count (basophil); LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg00945038 chr17:61921165 SMARCD2 0.53 9.39 0.46 9.85e-19 Prudent dietary pattern; LUSC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg11247378 chr22:39784982 NA -0.6 -10.33 -0.49 6.74e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs10761482 0.600 rs72807911 chr10:62228288 T/C cg18175470 chr10:62150864 ANK3 0.49 6.68 0.34 1.02e-10 Schizophrenia; LUSC cis rs4604732 0.588 rs12045675 chr1:247623915 C/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.43 6.33 0.33 7.95e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg18402987 chr7:1209562 NA 0.44 5.83 0.3 1.3e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg17376030 chr22:41985996 PMM1 0.51 6.39 0.33 5.65e-10 Vitiligo; LUSC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg00310523 chr12:86230176 RASSF9 0.51 9.45 0.46 6.23e-19 Major depressive disorder; LUSC cis rs7582720 1.000 rs72932588 chr2:203883193 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.76 8.22 0.41 4.56e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9393777 0.545 rs56303243 chr6:26485727 G/A cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); LUSC trans rs12210905 0.688 rs9393814 chr6:27372978 C/T cg14616345 chr9:133901267 LAMC3 -0.65 -5.95 -0.31 6.6e-9 Hip circumference adjusted for BMI; LUSC cis rs4689388 0.890 rs4481292 chr4:6298375 C/T cg25554036 chr4:6271136 WFS1 0.6 12.22 0.56 1.26e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2414856 0.510 rs72756981 chr15:64575487 G/T cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg24642439 chr20:33292090 TP53INP2 0.51 7.65 0.39 2.14e-13 Height; LUSC cis rs9457247 0.902 rs366938 chr6:167403538 T/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs10979 1.000 rs9390112 chr6:143896147 G/A cg25407410 chr6:143891975 LOC285740 -0.73 -11.8 -0.54 4.24e-27 Hypospadias; LUSC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg26668713 chr11:65405903 SIPA1 0.6 7.65 0.39 2.2e-13 Blood pressure (age interaction); LUSC cis rs8103278 0.662 rs16980051 chr19:46345886 T/C cg11657440 chr19:46296263 DMWD -0.48 -7.03 -0.36 1.15e-11 Coronary artery disease; LUSC cis rs9486719 0.843 rs2499793 chr6:96846402 A/C cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs11190604 0.747 rs11190516 chr10:102173525 G/A cg07080220 chr10:102295463 HIF1AN 0.6 7.77 0.39 9.77e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2898290 0.593 rs1600252 chr8:11345644 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.66 -0.34 1.13e-10 Systolic blood pressure; LUSC cis rs8060686 0.545 rs55897859 chr16:68286748 G/C cg05110241 chr16:68378359 PRMT7 -0.71 -7.36 -0.37 1.42e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs9560113 1.000 rs914026 chr13:112182029 G/A cg14154082 chr13:112174009 NA 0.38 7.64 0.39 2.31e-13 Menarche (age at onset); LUSC cis rs12618769 0.520 rs72821904 chr2:99084882 G/A cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs79349575 0.715 rs1058018 chr17:47000251 C/T cg22482690 chr17:47019901 SNF8 0.35 6.45 0.33 3.88e-10 Type 2 diabetes; LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.59 0.65 1.52e-41 Platelet count; LUSC cis rs7592578 0.599 rs62180992 chr2:191285732 A/G cg11845111 chr2:191398756 TMEM194B -0.85 -10.65 -0.5 5.39e-23 Diastolic blood pressure; LUSC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg22535103 chr8:58192502 C8orf71 -0.67 -7.5 -0.38 5.78e-13 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs508970 0.518 rs10792301 chr11:60888519 A/G cg27301655 chr11:60869634 CD5 -0.26 -5.8 -0.3 1.51e-8 Rheumatoid arthritis; LUSC cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg09184832 chr6:79620586 NA -0.44 -7.08 -0.36 8.31e-12 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg05585544 chr11:47624801 NA -0.42 -7.34 -0.37 1.67e-12 Subjective well-being; LUSC cis rs68170813 0.559 rs60255281 chr7:106963913 C/T cg02696742 chr7:106810147 HBP1 -0.64 -9.59 -0.46 2.08e-19 Coronary artery disease; LUSC cis rs2455601 0.882 rs11042118 chr11:8928791 T/A cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.77 -0.35 5.71e-11 Schizophrenia; LUSC cis rs208515 0.525 rs12215007 chr6:66671008 C/T cg07460842 chr6:66804631 NA -1.05 -14.2 -0.61 4.09e-36 Exhaled nitric oxide levels; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3809566 1.000 rs4775612 chr15:63332157 T/C cg05507819 chr15:63340323 TPM1 0.64 8.99 0.44 1.93e-17 Platelet count; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.89 0.55 1.95e-27 Prudent dietary pattern; LUSC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.24e-21 Electroencephalogram traits; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26691175 chr1:229761129 URB2;TAF5L 0.46 6.43 0.33 4.45e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg12564285 chr5:131593104 PDLIM4 0.43 8.42 0.42 1.09e-15 Blood metabolite levels; LUSC cis rs2979489 0.838 rs2979513 chr8:30397925 G/C cg26383811 chr8:30366931 RBPMS -0.52 -8.19 -0.41 5.76e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg16680214 chr1:154839983 KCNN3 -0.53 -10.02 -0.48 8e-21 Prostate cancer; LUSC cis rs17253792 0.822 rs79022053 chr14:56071721 A/G cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.9e-12 Putamen volume; LUSC cis rs3741151 0.773 rs58564192 chr11:73228904 G/A cg17517138 chr11:73019481 ARHGEF17 0.96 8.06 0.4 1.35e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg08859206 chr1:53392774 SCP2 -0.68 -12.74 -0.57 1.37e-30 Monocyte count; LUSC cis rs2742234 0.590 rs2503863 chr10:43667398 G/A cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs561341 0.528 rs11650908 chr17:30195425 T/C cg00745463 chr17:30367425 LRRC37B 0.53 7.11 0.36 7.07e-12 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg15839431 chr19:19639596 YJEFN3 0.42 5.89 0.31 9.46e-9 Tonsillectomy; LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg25036284 chr2:26402008 FAM59B -0.74 -10.79 -0.51 1.73e-23 Gut microbiome composition (summer); LUSC cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg07636037 chr3:49044803 WDR6 -0.68 -8.84 -0.44 5.66e-17 Menarche (age at onset); LUSC cis rs7095944 0.582 rs10901823 chr10:126488660 C/T cg08799069 chr10:126477246 METTL10 -0.39 -6.21 -0.32 1.55e-9 Asthma; LUSC trans rs11088226 0.681 rs1015047 chr21:33949423 A/G cg09050820 chr6:167586206 TCP10L2 0.72 9.89 0.48 2.09e-20 Gastritis; LUSC cis rs11822910 0.911 rs11828218 chr11:57196223 C/G cg00522883 chr11:57194120 SLC43A3 0.44 7.22 0.37 3.54e-12 Platelet distribution width; LUSC cis rs7527798 0.614 rs11118253 chr1:207825469 G/C cg09232269 chr1:207846808 CR1L -0.3 -6.39 -0.33 5.46e-10 Erythrocyte sedimentation rate; LUSC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg07414643 chr4:187882934 NA 0.58 10.99 0.52 3.39e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg26513180 chr16:89883248 FANCA 0.63 9.79 0.47 4.45e-20 Vitiligo; LUSC trans rs561341 0.941 rs2428338 chr17:30299629 T/C cg20587970 chr11:113659929 NA -1.12 -15.45 -0.65 5.26e-41 Hip circumference adjusted for BMI; LUSC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg11764359 chr7:65958608 NA -0.78 -12.7 -0.57 2.07e-30 Aortic root size; LUSC cis rs4499344 0.622 rs10401677 chr19:33061120 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.61 7.81 0.39 7.43e-14 Mean platelet volume; LUSC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg15839431 chr19:19639596 YJEFN3 -0.41 -5.72 -0.3 2.37e-8 Tonsillectomy; LUSC cis rs9419702 0.639 rs9419624 chr10:133534822 G/A cg04492858 chr10:133558786 NA 0.43 7.19 0.37 4.2e-12 Survival in rectal cancer; LUSC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 -0.38 -5.95 -0.31 6.96e-9 Vitiligo; LUSC cis rs1371867 0.846 rs1660332 chr8:101309490 A/G cg06002616 chr8:101225028 SPAG1 0.4 6.65 0.34 1.19e-10 Atrioventricular conduction; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.82 0.78 3.9e-70 Prudent dietary pattern; LUSC cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg07606381 chr6:8435919 SLC35B3 -0.73 -12.48 -0.56 1.32e-29 Motion sickness; LUSC cis rs11098499 0.954 rs9993199 chr4:120392873 A/G cg09307838 chr4:120376055 NA -0.78 -11.66 -0.54 1.32e-26 Corneal astigmatism; LUSC cis rs4776059 0.798 rs10851520 chr15:52912978 C/G cg22715398 chr15:52968154 KIAA1370 0.63 8.06 0.4 1.41e-14 Schizophrenia; LUSC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg06634786 chr22:41940651 POLR3H -0.56 -6.51 -0.34 2.73e-10 Vitiligo; LUSC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18404041 chr3:52824283 ITIH1 -0.52 -9.86 -0.47 2.62e-20 Bipolar disorder; LUSC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg09699651 chr6:150184138 LRP11 0.37 5.79 0.3 1.61e-8 Lung cancer; LUSC cis rs7000551 0.725 rs2469756 chr8:22360423 G/A cg12081754 chr8:22256438 SLC39A14 0.46 6.97 0.36 1.72e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.89 -0.31 9.24e-9 IgG glycosylation; LUSC trans rs4729127 1.000 rs4729127 chr7:94008535 A/G cg20086523 chr13:52378287 DHRS12 0.54 6.31 0.33 9.11e-10 Intelligence; LUSC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs7147624 1.000 rs2898816 chr14:66008160 T/C cg03016385 chr14:66212404 NA -0.83 -9.08 -0.45 9.48e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg11057378 chr10:81107060 PPIF 0.34 5.73 0.3 2.3e-8 Height; LUSC cis rs11122272 0.735 rs2247132 chr1:231493359 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.1 -0.48 4.17e-21 Hemoglobin concentration; LUSC cis rs34375054 0.558 rs67041765 chr12:125672913 T/G cg25124228 chr12:125621409 AACS -0.44 -6.54 -0.34 2.3e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg18404041 chr3:52824283 ITIH1 -0.59 -11.16 -0.52 8.53e-25 Bipolar disorder; LUSC cis rs939658 0.776 rs11631411 chr15:79445816 C/T cg17916960 chr15:79447300 NA -0.54 -11.0 -0.52 3.11e-24 Refractive error; LUSC cis rs2637266 0.783 rs2588333 chr10:78538952 A/G cg18941641 chr10:78392320 NA 0.37 6.58 0.34 1.83e-10 Pulmonary function; LUSC cis rs5758511 0.680 rs1033460 chr22:42619308 A/G cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.89 -0.31 9.19e-9 Birth weight; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.01 0.31 4.83e-9 Lymphocyte counts; LUSC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -8.07 -0.4 1.27e-14 Personality dimensions; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg27602981 chr16:89385820 ANKRD11 -0.38 -6.08 -0.32 3.27e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs1215050 0.740 rs1084777 chr4:99017542 C/T cg05340658 chr4:99064831 C4orf37 -0.45 -7.18 -0.37 4.45e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10779751 0.690 rs743577 chr1:11119135 G/A cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.08e-8 Body mass index; LUSC cis rs12286929 0.583 rs10458966 chr11:115102758 T/C cg04055981 chr11:115044050 NA 0.37 6.3 0.33 9.33e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10193935 0.901 rs13375 chr2:42559288 A/G cg27598129 chr2:42591480 NA -0.6 -8.46 -0.42 8.59e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg13047869 chr3:10149882 C3orf24 0.43 6.53 0.34 2.46e-10 Alzheimer's disease; LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8018967 0.622 rs2041073 chr14:73972535 C/T cg19682024 chr14:74008259 HEATR4;ACOT1 0.39 5.79 0.3 1.59e-8 Blood metabolite ratios; LUSC cis rs6942756 0.806 rs2566886 chr7:128917866 G/A cg02491457 chr7:128862824 NA 0.49 7.23 0.37 3.26e-12 White matter hyperintensity burden; LUSC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg25036284 chr2:26402008 FAM59B -0.7 -9.88 -0.48 2.22e-20 Gut microbiome composition (summer); LUSC cis rs4604732 0.631 rs12039642 chr1:247624898 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg15839431 chr19:19639596 YJEFN3 0.44 6.14 0.32 2.36e-9 Tonsillectomy; LUSC cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg15839431 chr19:19639596 YJEFN3 -0.64 -6.75 -0.35 6.5e-11 Bipolar disorder; LUSC cis rs950169 0.922 rs11630760 chr15:85113337 G/T cg12863693 chr15:85201151 NMB 0.34 6.81 0.35 4.58e-11 Schizophrenia; LUSC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.86e-18 Tonsillectomy; LUSC cis rs11785400 1.000 rs754957 chr8:143746416 A/G cg10596483 chr8:143751796 JRK 0.61 9.5 0.46 4.34e-19 Schizophrenia; LUSC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg21984481 chr17:79567631 NPLOC4 0.73 15.43 0.65 6.24e-41 Eye color traits; LUSC trans rs7824557 0.527 rs2736298 chr8:11235136 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.74 -0.39 1.2e-13 Retinal vascular caliber; LUSC cis rs11098499 0.954 rs11722872 chr4:120233030 G/C cg24375607 chr4:120327624 NA 0.78 11.31 0.53 2.61e-25 Corneal astigmatism; LUSC cis rs2295359 0.963 rs12030867 chr1:67627620 T/C cg17031739 chr1:67600172 NA 0.36 5.7 0.3 2.57e-8 Psoriasis; LUSC cis rs3768617 0.510 rs2027075 chr1:183073266 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 10.87 0.51 9.15e-24 Fuchs's corneal dystrophy; LUSC cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7945718 0.839 rs763373 chr11:12840342 C/G cg25843174 chr11:12811716 TEAD1 -0.31 -7.15 -0.36 5.63e-12 Educational attainment (years of education); LUSC trans rs1486139 1.000 rs111294851 chr7:46282965 C/T cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg19920283 chr7:105172520 RINT1 0.58 6.12 0.32 2.65e-9 Bipolar disorder (body mass index interaction); LUSC trans rs6496932 0.913 rs34896088 chr15:85821624 A/C cg26334166 chr20:61950840 COL20A1 0.31 6.12 0.32 2.57e-9 Central corneal thickness;Corneal structure; LUSC cis rs7107174 1.000 rs11601590 chr11:78073288 T/G cg02023728 chr11:77925099 USP35 0.47 7.06 0.36 9.75e-12 Testicular germ cell tumor; LUSC cis rs1728785 0.901 rs11642189 chr16:68583990 G/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs6484504 0.600 rs972714 chr11:31358875 T/G cg06552810 chr11:31128660 NA 0.39 6.68 0.34 1.02e-10 Red blood cell count; LUSC cis rs7296418 0.599 rs2277343 chr12:123794450 A/T cg00376283 chr12:123451042 ABCB9 0.71 10.83 0.51 1.3e-23 Platelet count; LUSC trans rs877282 1.000 rs11253362 chr10:770979 G/T cg22713356 chr15:30763199 NA 1.08 15.76 0.65 3.3e-42 Uric acid levels; LUSC cis rs1595825 0.838 rs60079260 chr2:198673636 G/A cg00982548 chr2:198649783 BOLL -0.6 -7.39 -0.37 1.19e-12 Ulcerative colitis; LUSC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg23324259 chr8:82754387 SNX16 -0.42 -5.68 -0.3 2.98e-8 Diastolic blood pressure; LUSC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.01 0.4 1.9e-14 Parkinson's disease; LUSC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg20203395 chr5:56204925 C5orf35 -0.76 -10.15 -0.49 2.81e-21 Initial pursuit acceleration; LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg08859206 chr1:53392774 SCP2 0.66 12.58 0.57 5.48e-30 Monocyte count; LUSC cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs5769707 0.521 rs739244 chr22:50060158 A/G cg10356904 chr22:49881777 NA -0.31 -6.36 -0.33 6.58e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6541297 1.000 rs7543050 chr1:230278291 C/G cg05784532 chr1:230284198 GALNT2 0.47 6.92 0.35 2.26e-11 Coronary artery disease; LUSC cis rs4595586 0.545 rs12823721 chr12:39386461 G/A cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg09034736 chr1:150693464 HORMAD1 -0.41 -5.88 -0.31 9.86e-9 Melanoma; LUSC trans rs1268789 0.545 rs959539 chr4:79372693 T/G cg06112894 chr8:141469983 TRAPPC9 0.23 6.27 0.32 1.12e-9 Hair shape;Hair morphology; LUSC cis rs7582720 1.000 rs74421437 chr2:203831252 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg06634786 chr22:41940651 POLR3H 0.51 6.11 0.32 2.82e-9 Vitiligo; LUSC cis rs8017423 0.967 rs11845329 chr14:90727749 C/T cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs9325144 0.577 rs12314639 chr12:39119869 T/C cg13010199 chr12:38710504 ALG10B -0.48 -7.56 -0.38 3.92e-13 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC trans rs6502050 0.799 rs8069827 chr17:80089168 C/T cg07393940 chr7:158741817 NA 0.38 6.89 0.35 2.77e-11 Life satisfaction; LUSC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg21951975 chr1:209979733 IRF6 0.6 7.73 0.39 1.24e-13 Cleft lip with or without cleft palate; LUSC cis rs79349575 0.749 rs58838744 chr17:46998902 A/G cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC cis rs941764 0.965 rs747159 chr14:91841030 A/C cg10511902 chr14:91842949 CCDC88C -0.43 -7.44 -0.38 8.45e-13 Breast cancer; LUSC cis rs9303401 0.659 rs12940212 chr17:56674474 T/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.08 0.45 9.42e-18 Cognitive test performance; LUSC cis rs477692 1.000 rs485576 chr10:131425496 G/C cg05714579 chr10:131428358 MGMT 0.53 7.86 0.4 5.38e-14 Response to temozolomide; LUSC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg18876405 chr7:65276391 NA -0.55 -8.81 -0.43 6.92e-17 Aortic root size; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17482706 chr9:77643371 C9orf41 0.43 6.14 0.32 2.28e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg16325326 chr1:53192061 ZYG11B 0.69 11.17 0.52 7.98e-25 Monocyte count; LUSC cis rs9992101 0.645 rs907446 chr4:77254804 C/T cg17010112 chr4:77227123 STBD1 -0.32 -5.98 -0.31 5.84e-9 Creatinine levels; LUSC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg04352962 chr1:209979756 IRF6 0.51 6.89 0.35 2.84e-11 Cleft lip with or without cleft palate; LUSC cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.49e-8 Breast cancer; LUSC cis rs2398893 0.924 rs11789837 chr9:96817369 T/G cg14459158 chr9:96720562 NA 0.31 6.03 0.31 4.3e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg13685833 chr1:53393034 SCP2 -0.39 -5.86 -0.31 1.11e-8 Monocyte count; LUSC cis rs240764 0.817 rs58266877 chr6:101156284 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.25 -0.32 1.22e-9 Neuroticism; LUSC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg03605463 chr16:89740564 NA 0.39 5.91 0.31 8.42e-9 Vitiligo; LUSC cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg22681709 chr2:178499509 PDE11A -0.5 -9.05 -0.44 1.22e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs523522 0.673 rs643372 chr12:121022640 C/G cg27279351 chr12:120934652 DYNLL1 0.66 8.95 0.44 2.43e-17 High light scatter reticulocyte count; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23860886 chr6:18155593 KDM1B;TPMT 0.38 6.14 0.32 2.36e-9 Asthma; LUSC cis rs8114671 0.562 rs2273683 chr20:33509523 C/T cg07148914 chr20:33460835 GGT7 0.57 8.69 0.43 1.63e-16 Height; LUSC cis rs11098499 1.000 rs6837898 chr4:120179154 C/T cg09307838 chr4:120376055 NA 0.73 10.49 0.5 1.93e-22 Corneal astigmatism; LUSC cis rs4682868 0.552 rs6771233 chr3:42922697 G/T cg21365077 chr3:42922735 NA 0.41 5.69 0.3 2.84e-8 Monocyte percentage of white cells; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.28 6.29 0.33 9.75e-10 Electroencephalogram traits; LUSC cis rs796364 0.806 rs78037592 chr2:201105734 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.8 -0.39 7.8500000000000006e-14 Schizophrenia; LUSC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg06850241 chr22:41845214 NA -0.32 -6.01 -0.31 4.96e-9 Vitiligo; LUSC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg14668632 chr7:2872130 GNA12 -0.47 -6.89 -0.35 2.73e-11 Height; LUSC cis rs968451 0.789 rs1003643 chr22:39676494 T/G cg17798944 chr22:39715225 SNORD43;RPL3 0.66 9.19 0.45 4.31e-18 Primary biliary cholangitis; LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg03354898 chr7:1950403 MAD1L1 -0.34 -6.65 -0.34 1.21e-10 Bipolar disorder and schizophrenia; LUSC cis rs7191439 0.858 rs2290902 chr16:88782676 A/G cg02389323 chr16:88786976 FAM38A 1.17 11.78 0.54 5.11e-27 Plateletcrit; LUSC cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -9.26 -0.45 2.59e-18 Chronic sinus infection; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23611233 chr1:249133059 ZNF672 0.38 5.98 0.31 5.69e-9 Asthma; LUSC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs7100689 0.556 rs946893 chr10:82023524 A/G cg01528321 chr10:82214614 TSPAN14 0.87 13.51 0.59 1.71e-33 Post bronchodilator FEV1; LUSC trans rs561341 1.000 rs510264 chr17:30323414 A/G cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs860295 0.812 rs3820594 chr1:155829511 C/T cg08949192 chr1:155289623 RUSC1;FDPS -0.35 -5.77 -0.3 1.79e-8 Body mass index; LUSC cis rs912057 0.632 rs1294429 chr6:6744652 G/A cg06612196 chr6:6737390 NA 0.56 11.11 0.52 1.32e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg07061783 chr6:25882402 NA -0.39 -6.08 -0.32 3.22e-9 Blood metabolite levels; LUSC trans rs10802346 0.545 rs2362252 chr1:246371574 A/C cg13514129 chr1:39547527 MACF1 0.72 11.86 0.54 2.49e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg03433033 chr1:76189801 ACADM 0.83 14.71 0.63 4.25e-38 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg27446573 chr6:127587934 RNF146 0.92 15.35 0.64 1.35e-40 Breast cancer; LUSC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg08888203 chr3:10149979 C3orf24 -0.45 -6.24 -0.32 1.34e-9 Alzheimer's disease; LUSC cis rs929354 0.772 rs3802124 chr7:156970609 G/A cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs3820068 0.603 rs1980607 chr1:15975237 A/G cg13390004 chr1:15929781 NA 0.41 6.84 0.35 3.76e-11 Systolic blood pressure; LUSC cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg21545522 chr1:205238299 TMCC2 0.51 9.81 0.47 3.88e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12410462 0.502 rs115241368 chr1:227795465 A/G cg04117972 chr1:227635322 NA 0.61 5.78 0.3 1.74e-8 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16290904 chr8:77912348 PXMP3 -0.42 -6.0 -0.31 5.03e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7829975 0.582 rs6983150 chr8:8792426 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.73 -0.35 7.52e-11 Mood instability; LUSC cis rs13191362 0.507 rs13210000 chr6:163176944 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.39 7.68 0.39 1.81e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.46 -0.5 2.48e-22 Alzheimer's disease; LUSC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg16545954 chr1:2118288 C1orf86 -0.29 -5.64 -0.3 3.54e-8 Height; LUSC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.34 6.72 0.35 7.94e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1595825 0.891 rs75163179 chr2:198895402 G/A cg10547527 chr2:198650123 BOLL -0.51 -6.23 -0.32 1.38e-9 Ulcerative colitis; LUSC cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.27 0.56 7.85e-29 Motion sickness; LUSC cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg24562669 chr7:97807699 LMTK2 0.37 6.42 0.33 4.66e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05901451 chr6:126070800 HEY2 -0.8 -14.33 -0.62 1.2e-36 Brugada syndrome; LUSC cis rs6469656 0.667 rs11781970 chr8:117762990 G/T cg24004040 chr8:117650383 NA -0.4 -5.85 -0.31 1.14e-8 Colorectal cancer; LUSC trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.94 -0.36 2.02e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs62458065 0.713 rs1597560 chr7:32493886 C/G cg20159608 chr7:32802032 NA -0.73 -9.12 -0.45 7.08e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs4474465 0.688 rs4367973 chr11:78284545 C/A cg27205649 chr11:78285834 NARS2 0.55 6.6 0.34 1.61e-10 Alzheimer's disease (survival time); LUSC cis rs10207628 0.601 rs6743470 chr2:127868435 G/T cg06223080 chr2:127868745 NA 0.38 6.56 0.34 2.06e-10 Psychosis and Alzheimer's disease; LUSC cis rs2540226 0.816 rs6719179 chr2:39981675 A/C cg23576258 chr2:39999331 THUMPD2 0.34 5.82 0.3 1.37e-8 Personality dimensions; LUSC cis rs9611519 0.780 rs9611528 chr22:41648502 T/C cg03806693 chr22:41940476 POLR3H -0.55 -8.11 -0.41 9.71e-15 Neuroticism; LUSC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg06636001 chr8:8085503 FLJ10661 0.69 11.33 0.53 2.12e-25 Systolic blood pressure; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.44 6.46 0.33 3.69e-10 Bipolar disorder; LUSC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg09323728 chr8:95962352 TP53INP1 -0.32 -5.97 -0.31 6.15e-9 Type 2 diabetes; LUSC cis rs765787 0.530 rs12442533 chr15:45529631 G/C cg25801113 chr15:45476975 SHF -0.36 -7.18 -0.37 4.43e-12 Uric acid levels; LUSC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 5.79 0.3 1.65e-8 Personality dimensions; LUSC cis rs881375 0.933 rs2239657 chr9:123671520 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.49 -7.04 -0.36 1.12e-11 Rheumatoid arthritis; LUSC cis rs4776059 0.798 rs7167494 chr15:52928453 C/G cg24008177 chr15:52972085 KIAA1370 -0.38 -6.86 -0.35 3.37e-11 Schizophrenia; LUSC cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg22535103 chr8:58192502 C8orf71 -0.84 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs1215050 0.791 rs503863 chr4:98707663 T/C cg05340658 chr4:99064831 C4orf37 0.45 7.1 0.36 7.73e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9457247 1.000 rs393727 chr6:167398632 T/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.74 -0.35 6.85e-11 Crohn's disease; LUSC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg14004847 chr7:1930337 MAD1L1 0.55 8.51 0.42 5.86e-16 Bipolar disorder and schizophrenia; LUSC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg13647721 chr17:30228624 UTP6 0.6 5.93 0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs6542838 0.641 rs4553869 chr2:99505940 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.39 -0.33 5.71e-10 Fear of minor pain; LUSC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg07424592 chr7:64974309 NA 0.7 6.15 0.32 2.24e-9 Diabetic kidney disease; LUSC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg19774624 chr17:42201019 HDAC5 -0.48 -6.97 -0.36 1.66e-11 Total body bone mineral density; LUSC cis rs7267979 1.000 rs34645895 chr20:25368373 A/G cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7674212 0.531 rs10006474 chr4:103928047 A/G cg16532752 chr4:104119610 CENPE -0.42 -5.87 -0.31 1.06e-8 Type 2 diabetes; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.69 10.55 0.5 1.24e-22 Lymphocyte counts; LUSC cis rs7091068 0.616 rs10748611 chr10:95482761 A/C cg20715218 chr10:95462985 C10orf4 0.62 6.99 0.36 1.54e-11 Urinary tract infection frequency; LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 14.57 0.62 1.47e-37 Platelet count; LUSC cis rs1448094 0.933 rs10779218 chr12:86320053 A/G cg02569458 chr12:86230093 RASSF9 0.42 6.77 0.35 5.89e-11 Major depressive disorder; LUSC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg18479299 chr3:125709523 NA -0.51 -5.83 -0.3 1.33e-8 Blood pressure (smoking interaction); LUSC cis rs6714710 0.580 rs55886305 chr2:98495661 T/G cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.18e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg08213375 chr14:104286397 PPP1R13B 0.42 7.41 0.38 1.03e-12 Reticulocyte count; LUSC cis rs9303401 0.632 rs7502541 chr17:57241019 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.49 7.26 0.37 2.65e-12 Cognitive test performance; LUSC cis rs7267979 1.000 rs1047171 chr20:25428786 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg27201871 chr17:79212816 C17orf56;C17orf89 0.37 6.22 0.32 1.47e-9 Tuberculosis; LUSC cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs7577851 0.715 rs6721259 chr2:69709919 A/G cg10773587 chr2:69614142 GFPT1 0.48 5.67 0.3 3.03e-8 Parkinson's disease (age of onset); LUSC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4776059 1.000 rs12914502 chr15:52911335 A/G cg25063058 chr15:52860530 ARPP19 0.41 5.78 0.3 1.74e-8 Schizophrenia; LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg26119090 chr2:26468346 HADHA;HADHB -1.04 -15.88 -0.66 1.05e-42 Gut microbiome composition (summer); LUSC trans rs4942242 0.640 rs9533571 chr13:44230136 C/T cg19169023 chr15:41853346 TYRO3 -0.58 -9.19 -0.45 4.41e-18 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg21724239 chr8:58056113 NA 0.59 7.11 0.36 6.93e-12 Developmental language disorder (linguistic errors); LUSC cis rs7572644 0.699 rs1506537 chr2:28181901 G/C cg27432699 chr2:27873401 GPN1 -0.51 -6.86 -0.35 3.28e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11190604 1.000 rs4919471 chr10:102299239 A/G cg07080220 chr10:102295463 HIF1AN 0.68 9.33 0.45 1.56e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg09904177 chr6:26538194 HMGN4 -0.51 -5.94 -0.31 6.98e-9 Intelligence (multi-trait analysis); LUSC cis rs6542838 0.641 rs1581249 chr2:99500630 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.44 -5.65 -0.3 3.42e-8 Fear of minor pain; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg04025307 chr7:1156635 C7orf50 0.4 6.18 0.32 1.84e-9 Longevity;Endometriosis; LUSC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg04733989 chr22:42467013 NAGA 0.42 7.04 0.36 1.12e-11 Cognitive function; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14478806 chr15:80351979 ZFAND6 0.51 7.18 0.37 4.58e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.49 -8.32 -0.41 2.32e-15 Lymphocyte counts; LUSC cis rs9467773 1.000 rs9357010 chr6:26527945 C/G cg11502198 chr6:26597334 ABT1 0.55 8.49 0.42 7.05e-16 Intelligence (multi-trait analysis); LUSC cis rs12410462 0.681 rs4131980 chr1:227572123 A/G cg04117972 chr1:227635322 NA 0.61 6.54 0.34 2.3e-10 Major depressive disorder; LUSC cis rs9650657 0.589 rs6985109 chr8:10761585 A/G cg21775007 chr8:11205619 TDH 0.52 7.09 0.36 8.13e-12 Neuroticism; LUSC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg05368731 chr17:41323189 NBR1 0.83 13.89 0.61 5.99e-35 Menopause (age at onset); LUSC cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg08975724 chr8:8085496 FLJ10661 0.48 7.3 0.37 2.1e-12 Mood instability; LUSC cis rs73200209 0.744 rs73200239 chr12:116684424 G/C cg01776926 chr12:116560359 MED13L -0.49 -5.98 -0.31 5.81e-9 Total body bone mineral density; LUSC cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg25358565 chr5:93447407 FAM172A 0.8 11.39 0.53 1.34e-25 Diabetic retinopathy; LUSC cis rs11711311 1.000 rs12631232 chr3:113497386 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.97 -0.31 6.22e-9 IgG glycosylation; LUSC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Parkinson's disease; LUSC cis rs9443645 0.509 rs9361459 chr6:79572922 A/G cg09184832 chr6:79620586 NA 0.41 6.46 0.33 3.72e-10 Intelligence (multi-trait analysis); LUSC trans rs208520 0.526 rs9354366 chr6:66788559 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.23 -25.77 -0.82 2.2e-81 Exhaled nitric oxide output; LUSC cis rs4595586 0.545 rs6580910 chr12:39390052 C/A cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs6121246 0.567 rs6058203 chr20:30198979 C/T cg13852791 chr20:30311386 BCL2L1 0.76 8.67 0.43 1.92e-16 Mean corpuscular hemoglobin; LUSC trans rs12210905 0.688 rs12195783 chr6:27444345 A/G cg11837749 chr1:55047332 ACOT11 0.73 6.17 0.32 1.97e-9 Hip circumference adjusted for BMI; LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.94 0.31 7.17e-9 Menopause (age at onset); LUSC cis rs9902453 0.967 rs12450441 chr17:28495021 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.19 0.41 5.67e-15 Coffee consumption (cups per day); LUSC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg11764359 chr7:65958608 NA -0.69 -10.73 -0.51 2.75e-23 Aortic root size; LUSC cis rs9326248 0.559 rs10892064 chr11:116896553 G/C cg26566898 chr11:117069891 TAGLN 0.34 6.46 0.33 3.77e-10 Blood protein levels; LUSC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.69e-9 Aortic root size; LUSC cis rs7264396 0.887 rs2236165 chr20:34096725 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.64 -0.34 1.3e-10 Total cholesterol levels; LUSC cis rs9392556 0.829 rs2783073 chr6:4118674 T/C cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.27 -0.32 1.12e-9 Blood metabolite levels; LUSC cis rs4820539 0.934 rs3788348 chr22:23467946 G/C cg21100191 chr22:23484243 RTDR1 0.91 15.73 0.65 3.99e-42 Bone mineral density; LUSC cis rs10792830 0.832 rs583162 chr11:85813817 A/G cg07180834 chr11:85838833 NA -0.3 -5.91 -0.31 8.55e-9 Psychosis and Alzheimer's disease; LUSC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.74 -0.35 6.93e-11 Developmental language disorder (linguistic errors); LUSC cis rs929354 0.742 rs10274687 chr7:156933181 T/G cg17757837 chr7:157058334 UBE3C 0.82 12.98 0.58 1.8e-31 Body mass index; LUSC cis rs1775715 0.737 rs1419171 chr10:32214831 C/A cg04359828 chr10:32216031 ARHGAP12 0.38 6.36 0.33 6.58e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg11584989 chr19:19387371 SF4 0.57 6.92 0.35 2.31e-11 Bipolar disorder; LUSC cis rs7107174 1.000 rs2510050 chr11:77982564 A/G cg02023728 chr11:77925099 USP35 0.5 7.27 0.37 2.53e-12 Testicular germ cell tumor; LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg22166914 chr1:53195759 ZYG11B -0.62 -10.29 -0.49 9.65e-22 Monocyte count; LUSC cis rs9611565 0.506 rs2024566 chr22:41697338 A/G cg03806693 chr22:41940476 POLR3H -0.63 -9.21 -0.45 3.59e-18 Vitiligo; LUSC trans rs853679 0.517 rs4713144 chr6:28106790 C/G cg06606381 chr12:133084897 FBRSL1 -0.45 -5.97 -0.31 6.07e-9 Depression; LUSC trans rs11148252 0.669 rs61958050 chr13:52994427 A/C cg18335740 chr13:41363409 SLC25A15 0.6 8.85 0.44 5.33e-17 Lewy body disease; LUSC cis rs561341 1.000 rs7210970 chr17:30262169 G/A cg00745463 chr17:30367425 LRRC37B -0.67 -7.92 -0.4 3.56e-14 Hip circumference adjusted for BMI; LUSC cis rs644799 0.544 rs687559 chr11:95598629 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.63 -9.29 -0.45 2.08e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6754311 0.773 rs309178 chr2:136611624 C/T cg07169764 chr2:136633963 MCM6 -0.6 -8.05 -0.4 1.47e-14 Mosquito bite size; LUSC cis rs7202877 0.706 rs467780 chr16:75437138 A/G cg03315344 chr16:75512273 CHST6 -0.42 -6.0 -0.31 5.21e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs644799 0.710 rs3748253 chr11:95519506 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.87 13.77 0.6 1.8e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12891047 0.866 rs1810523 chr14:68266708 C/T cg20999565 chr14:68265668 ZFYVE26 0.37 5.65 0.3 3.37e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs78456975 0.628 rs13426896 chr2:1554768 C/T cg12573674 chr2:1569213 NA -0.61 -7.39 -0.37 1.19e-12 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs10979 0.965 rs9403508 chr6:143887857 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.91 -0.55 1.66e-27 Hypospadias; LUSC cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs6714710 0.580 rs1838797 chr2:98454572 G/C cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg02675527 chr2:114030824 PAX8;LOC440839 0.36 5.72 0.3 2.41e-8 Lymphocyte counts; LUSC cis rs9788682 0.747 rs8042374 chr15:78908032 A/G cg06917634 chr15:78832804 PSMA4 -0.49 -6.51 -0.34 2.74e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6546537 0.911 rs13027712 chr2:69891367 C/T cg10773587 chr2:69614142 GFPT1 -0.53 -8.12 -0.41 9.2e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs2289328 0.825 rs35777573 chr15:40644246 T/A cg13931752 chr15:40660718 DISP2 0.45 5.89 0.31 9.38e-9 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs2816062 0.747 rs2816049 chr1:18893768 A/G cg18795169 chr1:18902165 NA -1.0 -23.93 -0.79 2.05e-74 Urate levels in lean individuals; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg12432903 chr7:1882776 MAD1L1 -0.38 -5.94 -0.31 7.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs72781680 0.716 rs2551334 chr2:24000396 G/A cg08917208 chr2:24149416 ATAD2B 0.6 6.91 0.35 2.44e-11 Lymphocyte counts; LUSC cis rs259282 0.589 rs6510271 chr19:33117666 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.72 10.51 0.5 1.67e-22 Schizophrenia; LUSC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC cis rs4460629 0.521 rs4361977 chr1:155076079 C/T cg23973274 chr1:155060172 NA -0.32 -6.22 -0.32 1.46e-9 Serum magnesium levels; LUSC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg17724175 chr1:150552817 MCL1 0.37 6.62 0.34 1.47e-10 Tonsillectomy; LUSC cis rs1387259 0.723 rs2732488 chr12:48771444 G/A cg04545296 chr12:48745243 ZNF641 0.3 5.74 0.3 2.17e-8 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg12935359 chr14:103987150 CKB 0.53 8.38 0.42 1.46e-15 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg19812747 chr11:111475976 SIK2 -0.56 -8.15 -0.41 7.2e-15 Primary sclerosing cholangitis; LUSC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg06481639 chr22:41940642 POLR3H -0.52 -5.94 -0.31 7e-9 Vitiligo; LUSC cis rs6541297 0.887 rs6541295 chr1:230281698 A/G cg20703242 chr1:230279135 GALNT2 0.57 7.17 0.37 4.92e-12 Coronary artery disease; LUSC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.53 0.5 1.45e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg08847533 chr14:75593920 NEK9 0.86 15.97 0.66 4.74e-43 Height; LUSC trans rs561341 1.000 rs501312 chr17:30329066 A/G cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs12618769 0.597 rs4850879 chr2:99113082 A/G cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg11494091 chr17:61959527 GH2 0.65 13.88 0.6 6.8000000000000005e-35 Prudent dietary pattern; LUSC cis rs9682041 0.561 rs6444928 chr3:170147875 A/G cg11886554 chr3:170076028 SKIL 0.63 7.32 0.37 1.83e-12 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.3 -5.73 -0.3 2.2e-8 Schizophrenia; LUSC cis rs9329221 0.662 rs4240645 chr8:10254463 C/G cg21775007 chr8:11205619 TDH -0.46 -5.87 -0.31 1.05e-8 Neuroticism; LUSC cis rs7917772 0.582 rs4917973 chr10:104333700 C/T cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.06 0.36 9.57e-12 Bipolar disorder; LUSC cis rs1865760 0.566 rs9467663 chr6:26021456 C/G cg16482183 chr6:26056742 HIST1H1C 0.5 7.28 0.37 2.43e-12 Height; LUSC cis rs6087990 0.899 rs4911110 chr20:31392366 C/T cg13636640 chr20:31349939 DNMT3B -0.93 -19.79 -0.73 3.2e-58 Ulcerative colitis; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg08677398 chr8:58056175 NA 0.52 6.58 0.34 1.79e-10 Developmental language disorder (linguistic errors); LUSC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg16006841 chr5:176797999 RGS14 -0.61 -9.8 -0.47 4.11e-20 Urinary electrolytes (magnesium/calcium ratio); LUSC cis rs1832871 0.672 rs7745596 chr6:158732991 T/A cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs5769765 0.817 rs11912619 chr22:50317401 G/A cg02269571 chr22:50332266 NA -0.6 -8.97 -0.44 2.2e-17 Schizophrenia; LUSC cis rs593982 0.858 rs663797 chr11:65552740 A/G cg08755490 chr11:65554678 OVOL1 1.43 16.36 0.67 1.36e-44 Atopic dermatitis; LUSC cis rs12421382 0.614 rs11213102 chr11:109385853 G/A cg27471124 chr11:109292789 C11orf87 0.38 6.89 0.35 2.71e-11 Schizophrenia; LUSC cis rs11098499 0.866 rs7665125 chr4:120402079 G/T cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.49e-19 Corneal astigmatism; LUSC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg12311346 chr5:56204834 C5orf35 -0.91 -13.22 -0.59 2.25e-32 Initial pursuit acceleration; LUSC trans rs9951602 0.512 rs9953258 chr18:76651199 A/C cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC cis rs11190604 1.000 rs2489036 chr10:102319581 A/G cg16342193 chr10:102329863 NA -0.36 -6.33 -0.33 8.1e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg22903471 chr2:27725779 GCKR -0.39 -6.68 -0.34 9.96e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs9309473 0.500 rs6546862 chr2:73860348 G/A cg20560298 chr2:73613845 ALMS1 0.46 7.02 0.36 1.27e-11 Metabolite levels; LUSC trans rs11039798 0.844 rs41431447 chr11:48983199 A/G cg03929089 chr4:120376271 NA 0.73 6.22 0.32 1.46e-9 Axial length; LUSC trans rs6502050 0.871 rs8066970 chr17:80076051 T/C cg07393940 chr7:158741817 NA -0.37 -6.74 -0.35 6.89e-11 Life satisfaction; LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg13138952 chr17:236013 NA -0.4 -6.25 -0.32 1.26e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg09826364 chr7:158789723 NA -0.39 -6.21 -0.32 1.6e-9 Facial morphology (factor 20); LUSC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg25019033 chr10:957182 NA 0.57 7.8 0.39 8.07e-14 Eosinophil percentage of granulocytes; LUSC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC cis rs5769707 0.642 rs4824070 chr22:50031521 T/C cg10356904 chr22:49881777 NA -0.3 -5.99 -0.31 5.56e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1062746 0.777 rs34400756 chr16:87372078 A/G cg02258303 chr16:87377426 FBXO31 -0.6 -10.08 -0.48 5.03e-21 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC trans rs11039798 0.920 rs11039940 chr11:48716316 C/T cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs4906332 1.000 rs17617935 chr14:103952886 A/T cg04998671 chr14:104000505 TRMT61A -0.45 -7.16 -0.36 5.08e-12 Coronary artery disease; LUSC cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg10253484 chr15:75165896 SCAMP2 -0.6 -8.32 -0.41 2.29e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7560272 0.512 rs13015885 chr2:73920482 G/T cg20560298 chr2:73613845 ALMS1 0.4 6.06 0.31 3.73e-9 Schizophrenia; LUSC cis rs3845702 0.736 rs6727890 chr2:180832675 T/C cg01881094 chr2:180872142 CWC22 -1.04 -12.46 -0.56 1.56e-29 Schizophrenia; LUSC trans rs8002861 0.810 rs9533664 chr13:44440527 T/C cg12856521 chr11:46389249 DGKZ 0.42 6.75 0.35 6.52e-11 Leprosy; LUSC cis rs7833986 0.534 rs17814089 chr8:56965563 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.72 -12.06 -0.55 4.86e-28 Height; LUSC cis rs7833986 0.501 rs9650314 chr8:56903610 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.68 10.98 0.51 3.87e-24 Height; LUSC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg03264133 chr6:25882463 NA -0.57 -9.38 -0.46 1.03e-18 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg15112475 chr7:1198522 ZFAND2A -0.28 -5.76 -0.3 1.88e-8 Longevity;Endometriosis; LUSC cis rs9398803 0.835 rs9321065 chr6:126744087 G/A cg19875578 chr6:126661172 C6orf173 0.43 6.27 0.32 1.11e-9 Male-pattern baldness; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10308682 chr20:5931622 MCM8;TRMT6 0.45 6.06 0.31 3.63e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs929354 0.772 rs10229630 chr7:157004790 C/T cg17757837 chr7:157058334 UBE3C 0.82 13.26 0.59 1.5e-32 Body mass index; LUSC cis rs7264396 0.790 rs6121020 chr20:34252006 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.82 -0.47 3.7e-20 Total cholesterol levels; LUSC cis rs1113500 0.862 rs11185264 chr1:108640506 T/C cg11967332 chr1:108735228 SLC25A24 0.4 5.96 0.31 6.28e-9 Growth-regulated protein alpha levels; LUSC cis rs7584330 0.554 rs7598559 chr2:238435398 A/G cg14458575 chr2:238380390 NA -0.51 -6.05 -0.31 3.99e-9 Prostate cancer; LUSC trans rs561341 1.000 rs548957 chr17:30302411 G/A cg27661571 chr11:113659931 NA -0.67 -7.74 -0.39 1.16e-13 Hip circumference adjusted for BMI; LUSC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.9 0.55 1.81e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs459571 0.876 rs2520095 chr9:136919568 A/G cg01294253 chr9:136912663 BRD3 0.34 5.92 0.31 8.12e-9 Platelet distribution width; LUSC cis rs10791323 0.569 rs1944734 chr11:133720077 G/A cg15485101 chr11:133734466 NA 0.42 7.68 0.39 1.82e-13 Childhood ear infection; LUSC trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg15704280 chr7:45808275 SEPT13 -0.82 -11.57 -0.53 2.95e-26 Coronary artery disease; LUSC cis rs722599 0.683 rs8022046 chr14:75278302 G/A cg08847533 chr14:75593920 NEK9 0.45 6.3 0.33 9.61e-10 IgG glycosylation; LUSC cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg16339924 chr4:17578868 LAP3 0.64 9.62 0.47 1.73e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.66 -0.43 2.03e-16 Bipolar disorder; LUSC cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -7.95 -0.4 2.99e-14 Schizophrenia; LUSC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21659725 chr3:3221576 CRBN -0.89 -18.69 -0.71 7.45e-54 Intelligence (multi-trait analysis); LUSC cis rs2562456 0.874 rs2562417 chr19:21711202 T/C cg00806126 chr19:22604979 ZNF98 0.37 5.75 0.3 2.05e-8 Pain; LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg23758822 chr17:41437982 NA 1.03 19.23 0.72 5.24e-56 Menopause (age at onset); LUSC trans rs2749592 0.531 rs1208559 chr10:38221370 T/C cg17830980 chr10:43048298 ZNF37B 0.42 6.21 0.32 1.54e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6754311 0.731 rs2322660 chr2:136557319 A/G cg07169764 chr2:136633963 MCM6 0.56 7.27 0.37 2.56e-12 Mosquito bite size; LUSC cis rs727505 1.000 rs67552763 chr7:124517857 A/G cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs10197940 0.624 rs3771901 chr2:152432481 G/A cg19508488 chr2:152266495 RIF1 0.5 7.11 0.36 7.19e-12 Lung cancer; LUSC cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg18681998 chr4:17616180 MED28 0.8 14.46 0.62 4.01e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs208520 0.690 rs1100981 chr6:66852052 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.87 -0.68 1.34e-46 Exhaled nitric oxide output; LUSC cis rs12620999 0.878 rs7593514 chr2:237980691 A/G cg23555395 chr2:238036564 NA 0.47 8.45 0.42 9.37e-16 Systemic lupus erythematosus; LUSC cis rs10791097 0.935 rs4601795 chr11:130729430 T/C cg12179176 chr11:130786555 SNX19 0.74 12.45 0.56 1.79e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg12310025 chr6:25882481 NA -0.77 -12.94 -0.58 2.44e-31 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03264670 chr22:29196746 XBP1 0.78 6.05 0.31 3.78e-9 Cognitive performance; LUSC cis rs7726839 0.794 rs6883536 chr5:599274 G/A cg03128945 chr5:622914 CEP72 -0.47 -6.7 -0.34 8.81e-11 Obesity-related traits; LUSC cis rs3540 0.533 rs7495080 chr15:91056681 G/A cg10434728 chr15:90938212 IQGAP1 -0.45 -9.17 -0.45 4.89e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs9359856 0.564 rs55722352 chr6:90365853 C/T cg13799429 chr6:90582589 CASP8AP2 -0.88 -8.96 -0.44 2.37e-17 Bipolar disorder; LUSC cis rs8060686 0.546 rs8047978 chr16:68143598 T/G cg09835421 chr16:68378352 PRMT7 -0.44 -5.72 -0.3 2.4e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.83e-30 Motion sickness; LUSC cis rs9296095 0.950 rs5745587 chr6:33545125 A/G cg14003231 chr6:33640908 ITPR3 0.46 7.16 0.36 5.28e-12 Platelet count; LUSC cis rs4891159 0.527 rs34956524 chr18:74130480 A/G cg24786174 chr18:74118243 ZNF516 0.96 21.5 0.76 5.45e-65 Longevity; LUSC cis rs9948 0.786 rs56797569 chr2:97413555 G/T cg01990225 chr2:97406019 LMAN2L -0.78 -5.86 -0.31 1.1e-8 Erectile dysfunction and prostate cancer treatment; LUSC cis rs34779708 0.931 rs4934524 chr10:35270921 G/C cg04310649 chr10:35416472 CREM -0.42 -6.39 -0.33 5.6e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9303401 0.659 rs12150264 chr17:56939927 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.54 0.6 1.33e-33 Cognitive test performance; LUSC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg12615879 chr12:58013172 SLC26A10 -0.29 -6.1 -0.32 2.92e-9 Multiple sclerosis; LUSC cis rs9467773 0.620 rs1027204 chr6:26639613 T/C cg11502198 chr6:26597334 ABT1 0.71 12.06 0.55 4.63e-28 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg27266027 chr21:40555129 PSMG1 0.4 5.78 0.3 1.75e-8 Cognitive function; LUSC cis rs7072216 0.763 rs2274246 chr10:100175060 C/T cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs2658782 0.724 rs2658770 chr11:93261886 A/G cg15737290 chr11:93063684 CCDC67 0.61 7.33 0.37 1.7e-12 Pulmonary function decline; LUSC cis rs2764208 0.860 rs205286 chr6:34551334 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.05 -0.31 3.85e-9 Systemic lupus erythematosus; LUSC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.6 8.83 0.43 6.15e-17 Total body bone mineral density; LUSC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg02574844 chr11:5959923 NA -0.43 -6.05 -0.31 3.8e-9 DNA methylation (variation); LUSC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg00579200 chr11:133705235 NA -0.39 -5.72 -0.3 2.39e-8 Childhood ear infection; LUSC cis rs7180079 0.563 rs7403103 chr15:65018526 C/T cg08069370 chr15:64387884 SNX1 0.53 5.95 0.31 6.84e-9 Monocyte count; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg10802521 chr3:52805072 NEK4 -0.46 -7.09 -0.36 7.8e-12 Electroencephalogram traits; LUSC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg00944433 chr1:107599041 PRMT6 0.39 7.15 0.36 5.48e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg02951883 chr7:2050386 MAD1L1 -0.52 -9.06 -0.44 1.13e-17 Bipolar disorder and schizophrenia; LUSC cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs854765 0.654 rs9911281 chr17:17762457 G/C cg16928487 chr17:17741425 SREBF1 0.45 8.92 0.44 3.14e-17 Total body bone mineral density; LUSC cis rs1577917 1.000 rs955197 chr6:86729675 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.79 -0.43 8.19e-17 Response to antipsychotic treatment; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03161075 chr14:51298083 NIN -0.48 -7.06 -0.36 9.74e-12 Electrocardiographic conduction measures; LUSC cis rs1348850 0.645 rs11889272 chr2:178432378 C/T cg27490568 chr2:178487706 NA 0.4 5.69 0.3 2.75e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1559088 0.649 rs4528686 chr19:33556074 A/G cg03563238 chr19:33554763 RHPN2 -0.4 -6.23 -0.32 1.43e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9916302 0.861 rs4795376 chr17:37669043 T/C cg07936489 chr17:37558343 FBXL20 -0.7 -9.54 -0.46 3.03e-19 Glomerular filtration rate (creatinine); LUSC cis rs9831754 0.704 rs9836909 chr3:78451594 A/G cg06138941 chr3:78371609 NA -0.55 -7.12 -0.36 6.59e-12 Calcium levels; LUSC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg10802521 chr3:52805072 NEK4 -0.53 -8.59 -0.43 3.42e-16 Bipolar disorder; LUSC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg11247378 chr22:39784982 NA -0.63 -12.21 -0.56 1.34e-28 Intelligence (multi-trait analysis); LUSC cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg23093090 chr10:104574429 C10orf26 -0.4 -6.7 -0.34 8.69e-11 Arsenic metabolism; LUSC cis rs1957429 0.614 rs380741 chr14:65322027 C/T cg23373153 chr14:65346875 NA -0.81 -7.48 -0.38 6.66e-13 Pediatric areal bone mineral density (radius); LUSC cis rs3099143 1.000 rs3106375 chr15:77142243 T/C cg21673338 chr15:77095150 SCAPER -0.81 -7.52 -0.38 5.15e-13 Recalcitrant atopic dermatitis; LUSC cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.4 -6.58 -0.34 1.79e-10 Neutrophil percentage of white cells; LUSC cis rs7786808 0.505 rs67537656 chr7:158192646 C/T cg09998033 chr7:158218633 PTPRN2 0.45 7.06 0.36 9.5e-12 Obesity-related traits; LUSC cis rs6723108 0.591 rs13399952 chr2:135394404 A/G cg12500956 chr2:135428796 TMEM163 -0.28 -6.59 -0.34 1.71e-10 Type 2 diabetes; LUSC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg07777115 chr5:623756 CEP72 -0.45 -5.72 -0.3 2.35e-8 Obesity-related traits; LUSC cis rs7719624 0.811 rs17689879 chr5:135393138 C/T cg12897067 chr5:135418308 NA -0.43 -6.31 -0.33 8.82e-10 Response to cytidine analogues (gemcitabine); LUSC cis rs9462027 0.583 rs2814995 chr6:34621171 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.09 -0.32 3.12e-9 Systemic lupus erythematosus; LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg11062466 chr8:58055876 NA 0.75 8.89 0.44 4e-17 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.521 rs11777887 chr8:11036799 C/G cg15556689 chr8:8085844 FLJ10661 0.49 7.27 0.37 2.64e-12 Triglycerides; LUSC cis rs10097731 0.901 rs10464931 chr8:82042664 A/G cg25230327 chr8:82042993 NA 0.45 6.65 0.34 1.21e-10 Serum total protein level; LUSC cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.55 0.46 2.83e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs6545883 1.000 rs778762 chr2:61782921 G/T cg15711740 chr2:61764176 XPO1 -0.5 -7.94 -0.4 3.14e-14 Tuberculosis; LUSC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg04553112 chr3:125709451 NA -0.5 -5.66 -0.3 3.27e-8 Blood pressure (smoking interaction); LUSC cis rs713587 0.521 rs6545766 chr2:25077856 C/T cg01884057 chr2:25150051 NA 0.39 8.54 0.42 4.78e-16 Body mass index in non-asthmatics; LUSC cis rs7577851 0.625 rs66931274 chr2:69580970 C/T cg10773587 chr2:69614142 GFPT1 0.56 6.2 0.32 1.64e-9 Parkinson's disease (age of onset); LUSC cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg03146154 chr1:46216737 IPP 0.56 8.23 0.41 4.12e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs17685 0.712 rs7785025 chr7:75628101 C/T cg19862616 chr7:65841803 NCRNA00174 -1.12 -19.47 -0.73 6.08e-57 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11857246 chr1:11741390 MAD2L2 -0.5 -6.12 -0.32 2.57e-9 Bipolar disorder and schizophrenia; LUSC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg10018233 chr7:150070692 REPIN1 0.4 6.62 0.34 1.46e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg26408565 chr15:76604113 ETFA -0.5 -8.05 -0.4 1.46e-14 Blood metabolite levels; LUSC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg09904177 chr6:26538194 HMGN4 -0.39 -5.68 -0.3 2.93e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs561341 0.709 rs8068049 chr17:30183857 T/C cg20587970 chr11:113659929 NA 1.25 13.53 0.6 1.41e-33 Hip circumference adjusted for BMI; LUSC trans rs853679 0.517 rs9348797 chr6:28137533 G/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs7615316 0.779 rs3816805 chr3:142076059 A/G cg16271453 chr3:142027066 XRN1 -0.4 -6.99 -0.36 1.51e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg06850241 chr22:41845214 NA 0.32 6.06 0.31 3.58e-9 Vitiligo; LUSC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg15839431 chr19:19639596 YJEFN3 -0.41 -5.72 -0.3 2.37e-8 Tonsillectomy; LUSC cis rs12497850 0.644 rs11928552 chr3:48739883 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.37 0.42 1.57e-15 Parkinson's disease; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg26304593 chr6:42947056 PEX6 -0.54 -8.49 -0.42 6.8e-16 Plasma homocysteine levels (post-methionine load test); LUSC cis rs72949976 0.646 rs1441171 chr2:214033637 G/T cg08319019 chr2:214017104 IKZF2 0.66 11.03 0.52 2.54e-24 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs7572644 0.782 rs10175826 chr2:28261384 G/A cg27432699 chr2:27873401 GPN1 -0.53 -6.94 -0.36 2e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7584330 0.910 rs6757376 chr2:238400036 G/C cg14458575 chr2:238380390 NA 0.67 11.64 0.54 1.65e-26 Prostate cancer; LUSC cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.15e-8 Breast cancer; LUSC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg26408565 chr15:76604113 ETFA -0.49 -7.85 -0.39 5.83e-14 Blood metabolite levels; LUSC cis rs739496 0.947 rs1029388 chr12:111926901 A/G cg10833066 chr12:111807467 FAM109A 0.33 6.15 0.32 2.17e-9 Platelet count; LUSC cis rs7560272 0.669 rs13008860 chr2:73774019 G/A cg20560298 chr2:73613845 ALMS1 -0.39 -5.94 -0.31 7.04e-9 Schizophrenia; LUSC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg18352616 chr4:3374830 RGS12 0.35 7.03 0.36 1.15e-11 Serum sulfate level; LUSC cis rs921665 0.831 rs3887811 chr2:3182777 A/G cg16434511 chr2:3151078 NA -0.62 -6.74 -0.35 7.05e-11 World class endurance athleticism; LUSC cis rs2067615 0.560 rs10467028 chr12:107076405 A/G cg15890332 chr12:107067104 RFX4 0.34 6.2 0.32 1.69e-9 Heart rate; LUSC cis rs3770081 1.000 rs56977454 chr2:86204014 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.08 -6.72 -0.35 7.64e-11 Facial emotion recognition (sad faces); LUSC cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg13010199 chr12:38710504 ALG10B -0.63 -10.7 -0.51 3.65e-23 Heart rate; LUSC cis rs11098499 0.863 rs11731756 chr4:120478696 T/G cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg06238570 chr21:40685208 BRWD1 0.49 7.64 0.39 2.28e-13 Cognitive function; LUSC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg15664640 chr17:80829946 TBCD 0.63 11.19 0.52 6.99e-25 Breast cancer; LUSC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg27165867 chr14:105738592 BRF1 -0.52 -7.6 -0.38 3.01e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg17264618 chr3:40429014 ENTPD3 0.34 6.9 0.35 2.66e-11 Renal cell carcinoma; LUSC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg16325326 chr1:53192061 ZYG11B 0.94 17.54 0.69 2.74e-49 Monocyte count; LUSC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg00745463 chr17:30367425 LRRC37B -0.79 -9.21 -0.45 3.67e-18 Hip circumference adjusted for BMI; LUSC cis rs963731 0.649 rs2278914 chr2:39218552 G/A cg04010122 chr2:39346883 SOS1 -0.79 -5.73 -0.3 2.2e-8 Corticobasal degeneration; LUSC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg13393036 chr8:95962371 TP53INP1 -0.32 -6.18 -0.32 1.84e-9 Type 2 diabetes; LUSC cis rs7089973 0.624 rs10885613 chr10:116589400 G/A cg23260525 chr10:116636907 FAM160B1 0.43 9.21 0.45 3.72e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs16937 0.662 rs10900456 chr1:205145005 C/T cg00857998 chr1:205179979 DSTYK 0.47 6.55 0.34 2.13e-10 Schizophrenia; LUSC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg06544989 chr22:39130855 UNC84B 0.33 5.76 0.3 1.86e-8 Menopause (age at onset); LUSC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg03060546 chr3:49711283 APEH 0.71 12.09 0.55 3.6e-28 Resting heart rate; LUSC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg04369109 chr6:150039330 LATS1 -0.55 -8.09 -0.4 1.1e-14 Lung cancer; LUSC cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.46e-10 Body mass index; LUSC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.47e-12 Lung disease severity in cystic fibrosis; LUSC cis rs2200578 1.000 rs72954221 chr2:99899445 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 0.61 7.16 0.36 5.11e-12 IgG glycosylation; LUSC cis rs73206853 0.698 rs1018134 chr12:111121119 G/A cg12870014 chr12:110450643 ANKRD13A 0.67 7.36 0.37 1.45e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4631830 0.896 rs7077830 chr10:51522276 C/G cg20129853 chr10:51489980 NA 0.34 7.04 0.36 1.13e-11 Prostate-specific antigen levels; LUSC cis rs4073582 0.595 rs801736 chr11:65928430 A/T cg14036092 chr11:66035641 RAB1B 0.42 5.94 0.31 7.35e-9 Gout; LUSC cis rs2204008 0.536 rs12368354 chr12:38042798 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.74 0.65 3.8e-42 Bladder cancer; LUSC cis rs11168351 0.591 rs4258439 chr12:48468652 A/G cg24011408 chr12:48396354 COL2A1 -0.53 -8.72 -0.43 1.33e-16 Bipolar disorder and schizophrenia; LUSC cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -6.89 -0.35 2.83e-11 Bipolar disorder; LUSC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6121246 0.529 rs6060210 chr20:30187681 C/T cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs9788682 0.747 rs8042494 chr15:78908010 C/T cg24631222 chr15:78858424 CHRNA5 0.67 9.23 0.45 3.08e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs921968 0.643 rs832806 chr2:219473914 A/T cg02176678 chr2:219576539 TTLL4 0.6 10.54 0.5 1.34e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs10493773 0.928 rs12751296 chr1:86176968 G/A cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.35 -0.46 1.28e-18 Urate levels in overweight individuals; LUSC cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg24531977 chr5:56204891 C5orf35 -0.83 -13.02 -0.58 1.22e-31 Coronary artery disease; LUSC cis rs1712517 0.771 rs61871160 chr10:105144288 C/T cg05636881 chr10:105038444 INA 0.4 6.67 0.34 1.09e-10 Migraine; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04314308 chr19:19336150 NCAN -0.47 -6.32 -0.33 8.45e-10 Hepatitis; LUSC trans rs62458065 0.568 rs62463963 chr7:32486691 C/T cg00845942 chr12:64062724 DPY19L2 -0.56 -6.72 -0.35 7.64e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC trans rs1814175 0.935 rs7482690 chr11:49648814 C/T cg15704280 chr7:45808275 SEPT13 -1.09 -21.56 -0.76 3.12e-65 Height; LUSC trans rs3749237 0.964 rs62260719 chr3:49852419 G/A cg21659725 chr3:3221576 CRBN 0.61 8.63 0.43 2.6e-16 Resting heart rate; LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg01802117 chr1:53393560 SCP2 -0.39 -6.45 -0.33 3.94e-10 Monocyte count; LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg22920501 chr2:26401640 FAM59B -0.78 -10.99 -0.52 3.46e-24 Gut microbiome composition (summer); LUSC trans rs1998174 0.509 rs10753205 chr1:171839958 G/A cg13482142 chr2:234261155 NA 0.42 6.11 0.32 2.81e-9 Platelet distribution width; LUSC cis rs7264396 0.563 rs2425111 chr20:34319765 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.47 -0.42 8.07e-16 Total cholesterol levels; LUSC cis rs977987 0.843 rs11149820 chr16:75422760 G/A cg03315344 chr16:75512273 CHST6 0.53 10.35 0.49 6.07e-22 Dupuytren's disease; LUSC cis rs9814567 0.731 rs34797591 chr3:134192516 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.77 10.27 0.49 1.14e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg04586622 chr2:25135609 ADCY3 0.38 8.09 0.4 1.08e-14 Body mass index; LUSC cis rs478304 1.000 rs478304 chr11:65494260 G/T cg05805236 chr11:65401703 PCNXL3 0.43 7.11 0.36 7.12e-12 Acne (severe); LUSC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.43e-34 Diabetic kidney disease; LUSC cis rs9902453 0.967 rs4429345 chr17:28458105 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.54 -8.21 -0.41 5e-15 Coffee consumption (cups per day); LUSC cis rs7267979 0.932 rs2260997 chr20:25256266 A/C cg03522245 chr20:25566470 NINL -0.35 -5.68 -0.3 2.97e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs7824557 0.767 rs4559208 chr8:11153925 C/G cg06636001 chr8:8085503 FLJ10661 0.51 7.89 0.4 4.47e-14 Retinal vascular caliber; LUSC cis rs751728 0.664 rs943478 chr6:33750940 T/A cg25922239 chr6:33757077 LEMD2 0.42 6.29 0.33 9.76e-10 Crohn's disease; LUSC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.1 -0.32 2.87e-9 Lung cancer; LUSC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.72 12.46 0.56 1.59e-29 Total body bone mineral density; LUSC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Melanoma; LUSC cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.98 0.72 5.41e-55 Chronic sinus infection; LUSC cis rs939658 0.805 rs35291410 chr15:79438660 C/T cg17916960 chr15:79447300 NA -0.53 -10.57 -0.5 1.05e-22 Refractive error; LUSC cis rs9653442 0.835 rs1561230 chr2:100746642 C/T cg07810366 chr2:100720526 AFF3 0.5 8.74 0.43 1.12e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg13319975 chr6:146136371 FBXO30 -0.53 -8.07 -0.4 1.27e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg20307385 chr11:47447363 PSMC3 -0.48 -6.26 -0.32 1.21e-9 Subjective well-being; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg26668828 chr6:292823 DUSP22 -0.52 -7.78 -0.39 9.08e-14 Menopause (age at onset); LUSC cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.33 -6.11 -0.32 2.82e-9 IgG glycosylation; LUSC cis rs6459804 0.787 rs78566714 chr7:157508951 G/A cg05731713 chr7:157510257 PTPRN2 0.49 9.39 0.46 9.76e-19 Bipolar disorder and schizophrenia; LUSC cis rs2011503 0.941 rs55822665 chr19:19383298 C/T cg22782873 chr19:19639568 YJEFN3 -0.47 -5.85 -0.3 1.17e-8 Bipolar disorder; LUSC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg09034736 chr1:150693464 HORMAD1 0.48 6.97 0.36 1.69e-11 Tonsillectomy; LUSC cis rs4808199 0.948 rs2301671 chr19:19466269 C/T cg03709012 chr19:19516395 GATAD2A 0.98 11.97 0.55 1.05e-27 Nonalcoholic fatty liver disease; LUSC cis rs6599077 1.000 rs6808392 chr3:40096750 T/C cg13683864 chr3:40499215 RPL14 -0.6 -7.64 -0.39 2.38e-13 Sleep-related phenotypes; LUSC cis rs921968 0.565 rs6436069 chr2:219597185 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.08 -0.48 4.89e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs748404 0.697 rs579651 chr15:43558376 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.75 0.3 2.04e-8 Lung cancer; LUSC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg11645453 chr3:52864694 ITIH4 0.36 8.32 0.41 2.33e-15 Bipolar disorder; LUSC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.5 -8.28 -0.41 3.09e-15 IgG glycosylation; LUSC cis rs6964587 1.000 rs7811564 chr7:91663364 A/G cg17063962 chr7:91808500 NA 0.6 9.41 0.46 8.58e-19 Breast cancer; LUSC cis rs9486715 0.838 rs9400034 chr6:96954566 C/T cg06623918 chr6:96969491 KIAA0776 0.94 17.57 0.69 2.21e-49 Headache; LUSC cis rs7202877 0.706 rs467780 chr16:75437138 A/G cg04384234 chr16:75411784 CFDP1 0.66 9.06 0.44 1.14e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs10779751 0.770 rs7553827 chr1:11222393 C/T cg08854313 chr1:11322531 MTOR 0.84 12.74 0.57 1.49e-30 Body mass index; LUSC cis rs1372520 0.627 rs2583964 chr4:90727218 A/G cg01966878 chr4:90757139 SNCA -0.43 -6.22 -0.32 1.49e-9 Neuroticism; LUSC trans rs2832191 0.716 rs2297252 chr21:30377104 G/A cg14791747 chr16:20752902 THUMPD1 -0.42 -6.42 -0.33 4.76e-10 Dental caries; LUSC cis rs11785693 0.909 rs62489556 chr8:4968149 G/A cg26367366 chr8:4980734 NA 0.84 8.69 0.43 1.6e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs1950626 0.662 rs72700538 chr14:101441911 C/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.77 0.39 9.82e-14 Pelvic organ prolapse (moderate/severe); LUSC trans rs8073060 0.586 rs2011897 chr17:34054408 A/T cg19694781 chr19:47549865 TMEM160 1.13 18.46 0.71 6.01e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9399401 0.925 rs1040526 chr6:142735816 A/G cg03128060 chr6:142623767 GPR126 0.34 6.28 0.32 1.06e-9 Chronic obstructive pulmonary disease; LUSC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg26566898 chr11:117069891 TAGLN 0.37 7.26 0.37 2.81e-12 Blood protein levels; LUSC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg20476274 chr7:133979776 SLC35B4 0.87 16.89 0.68 1.02e-46 Mean platelet volume; LUSC trans rs4714291 0.802 rs7759622 chr6:40114735 C/T cg02267698 chr19:7991119 CTXN1 -0.55 -8.12 -0.41 9.13e-15 Strep throat; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg08472276 chr7:1133186 C7orf50;GPER -0.42 -6.89 -0.35 2.81e-11 Longevity;Endometriosis; LUSC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.01e-11 Tonsillectomy; LUSC cis rs11148252 0.595 rs9526968 chr13:53240183 T/C cg00495681 chr13:53174319 NA 0.79 15.17 0.64 6.69e-40 Lewy body disease; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg14092988 chr3:52407081 DNAH1 -0.33 -6.46 -0.33 3.64e-10 Bipolar disorder; LUSC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg24324837 chr19:49891574 CCDC155 0.49 6.25 0.32 1.23e-9 Multiple sclerosis; LUSC cis rs2425143 1.000 rs11696527 chr20:34245379 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.21 -0.32 1.58e-9 Blood protein levels; LUSC cis rs6563842 0.563 rs4575411 chr13:41277794 C/G cg21288729 chr13:41239152 FOXO1 0.54 8.31 0.41 2.35e-15 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC cis rs73198271 0.694 rs115037021 chr8:8647080 A/C cg15556689 chr8:8085844 FLJ10661 -0.49 -6.32 -0.33 8.29e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7542375 0.507 rs2784270 chr1:221094967 C/T cg16008148 chr1:221062819 NA -0.42 -8.31 -0.41 2.49e-15 Obesity-related traits; LUSC cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.95 -17.65 -0.69 9.86e-50 Chronic sinus infection; LUSC trans rs1486139 1.000 rs1385932 chr7:46268354 C/T cg17534202 chr9:96721102 NA -0.35 -6.11 -0.32 2.85e-9 Select biomarker traits; LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg26314531 chr2:26401878 FAM59B -0.73 -10.21 -0.49 1.79e-21 Gut microbiome composition (summer); LUSC trans rs12987465 0.545 rs116021360 chr2:49708739 G/T cg16509045 chr9:77502963 TRPM6 -0.3 -5.97 -0.31 6.06e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide); LUSC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg00484396 chr16:3507460 NAT15 -0.42 -6.85 -0.35 3.54e-11 Body mass index (adult); LUSC trans rs1493916 0.721 rs4799723 chr18:31367050 T/G cg27147174 chr7:100797783 AP1S1 -0.65 -10.45 -0.5 2.58e-22 Life satisfaction; LUSC cis rs17102423 0.692 rs762810 chr14:65544367 C/A cg11161011 chr14:65562177 MAX -0.81 -12.23 -0.56 1.1e-28 Obesity-related traits; LUSC trans rs7824557 0.564 rs12550129 chr8:11233917 C/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.69 -0.39 1.67e-13 Retinal vascular caliber; LUSC cis rs478607 0.764 rs2666558 chr11:64481579 G/A cg19131476 chr11:64387923 NRXN2 -0.31 -5.67 -0.3 3.05e-8 Urate levels; LUSC cis rs3820928 1.000 rs6752707 chr2:227766822 C/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.73 -0.39 1.32e-13 Pulmonary function; LUSC trans rs853679 0.517 rs56310871 chr6:28044482 A/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.1 -0.32 2.97e-9 Depression; LUSC cis rs12594515 1.000 rs11854554 chr15:45994546 C/G cg19682013 chr15:45996608 NA 0.39 5.8 0.3 1.52e-8 Waist circumference;Weight; LUSC cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs868036 0.681 rs4776976 chr15:68103291 C/T cg24579218 chr15:68104479 NA -0.39 -6.78 -0.35 5.39e-11 Restless legs syndrome; LUSC cis rs9952991 0.941 rs2542150 chr18:12779763 G/C cg23598886 chr18:12777645 NA 0.65 6.6 0.34 1.61e-10 Inflammatory skin disease; LUSC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg23649088 chr2:200775458 C2orf69 -0.58 -7.11 -0.36 7.05e-12 Schizophrenia; LUSC cis rs8114671 0.967 rs1415773 chr20:33765585 G/A cg07148914 chr20:33460835 GGT7 0.46 6.9 0.35 2.59e-11 Height; LUSC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg11752832 chr7:134001865 SLC35B4 0.52 7.86 0.4 5.41e-14 Mean platelet volume; LUSC cis rs5758659 0.967 rs5751250 chr22:42639645 T/G cg04733989 chr22:42467013 NAGA 0.4 6.41 0.33 4.89e-10 Cognitive function; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg09033563 chr22:24373618 LOC391322 0.46 6.33 0.33 7.8e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs6600671 1.000 rs1832558 chr1:121177380 A/G cg00646200 chr1:148855367 NA 0.47 7.52 0.38 5.11e-13 Hip geometry; LUSC cis rs7618501 0.966 rs2352974 chr3:49890613 C/T cg13072238 chr3:49761600 GMPPB 0.41 6.73 0.35 7.48e-11 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg05347473 chr6:146136440 FBXO30 0.47 7.68 0.39 1.75e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs7484658 chr12:34515879 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.19e-33 Morning vs. evening chronotype; LUSC cis rs4285028 0.948 rs71329247 chr3:121681523 C/T cg11130432 chr3:121712080 ILDR1 -0.65 -9.77 -0.47 5.4e-20 Multiple sclerosis; LUSC cis rs78572108 0.858 rs72613887 chr2:42267914 G/A cg00607755 chr2:42274082 PKDCC 0.34 5.83 0.3 1.28e-8 Total body bone mineral density; LUSC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg08847533 chr14:75593920 NEK9 -0.79 -13.67 -0.6 4.42e-34 Height; LUSC trans rs8072100 0.666 rs9913503 chr17:45776330 T/G cg03886242 chr7:26192032 NFE2L3 -0.39 -5.97 -0.31 6.05e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg00677455 chr12:58241039 CTDSP2 0.54 6.91 0.35 2.4e-11 Multiple sclerosis; LUSC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg18350739 chr11:68623251 NA -0.36 -6.33 -0.33 7.68e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg11645453 chr3:52864694 ITIH4 -0.49 -10.4 -0.49 3.89e-22 Schizophrenia; LUSC cis rs644799 0.648 rs1255178 chr11:95471908 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.59 9.13 0.45 6.77e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs6982636 1.000 rs2980871 chr8:126488930 A/G cg13325919 chr3:181432053 SOX2;SOX2OT -0.34 -6.3 -0.33 9.35e-10 Lipid metabolism phenotypes; LUSC cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg10253484 chr15:75165896 SCAMP2 0.41 5.8 0.3 1.52e-8 Systemic lupus erythematosus; LUSC trans rs10435719 0.638 rs67146188 chr8:11782433 A/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.46e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs11098499 0.697 rs4560394 chr4:120313435 T/G cg24375607 chr4:120327624 NA 0.76 11.11 0.52 1.29e-24 Corneal astigmatism; LUSC cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg18806716 chr10:30721971 MAP3K8 -0.7 -10.7 -0.51 3.51e-23 Inflammatory bowel disease; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg03352830 chr11:487213 PTDSS2 0.7 8.83 0.44 5.97e-17 Body mass index; LUSC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg26513180 chr16:89883248 FANCA 0.78 6.39 0.33 5.68e-10 Skin colour saturation; LUSC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.54 -7.74 -0.39 1.17e-13 Tuberculosis; LUSC cis rs80130819 0.748 rs2634679 chr12:48735304 G/T cg24011408 chr12:48396354 COL2A1 0.44 5.66 0.3 3.31e-8 Prostate cancer; LUSC cis rs2932538 0.922 rs6659677 chr1:113087076 G/C cg22162597 chr1:113214053 CAPZA1 0.7 9.98 0.48 1.03e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg05585544 chr11:47624801 NA -0.42 -7.34 -0.37 1.67e-12 Subjective well-being; LUSC cis rs12971120 0.838 rs747176 chr18:72154931 G/A cg26446133 chr18:72167187 CNDP2 -0.79 -10.96 -0.51 4.33e-24 Refractive error; LUSC cis rs244293 0.760 rs12952166 chr17:53005586 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.84 -0.3 1.27e-8 Menarche (age at onset); LUSC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 12.73 0.57 1.55e-30 Total body bone mineral density; LUSC cis rs9650315 0.866 rs11990562 chr8:57198214 A/C cg23139584 chr8:56987506 RPS20;SNORD54 -0.56 -6.77 -0.35 5.65e-11 Height; LUSC cis rs62400317 0.859 rs62438863 chr6:45040592 C/T cg18551225 chr6:44695536 NA -0.42 -6.74 -0.35 7.02e-11 Total body bone mineral density; LUSC trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg03929089 chr4:120376271 NA -0.84 -11.49 -0.53 5.46e-26 Coronary artery disease; LUSC cis rs2798269 1.000 rs1200046 chr13:22131160 C/A cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.13 -0.32 2.42e-9 PR segment; LUSC cis rs10193935 0.901 rs10189710 chr2:42573102 C/G cg27598129 chr2:42591480 NA -0.6 -8.24 -0.41 3.96e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs3126085 1.000 rs2338556 chr1:152309427 T/A cg26876637 chr1:152193138 HRNR -0.44 -5.67 -0.3 3.13e-8 Atopic dermatitis; LUSC cis rs9790314 1.000 rs9850455 chr3:161017192 G/A cg03342759 chr3:160939853 NMD3 -0.51 -8.7 -0.43 1.59e-16 Morning vs. evening chronotype; LUSC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg27432699 chr2:27873401 GPN1 -0.57 -8.57 -0.42 3.87e-16 Total body bone mineral density; LUSC cis rs9393777 0.528 rs9467989 chr6:27064275 C/T cg12826209 chr6:26865740 GUSBL1 0.65 8.63 0.43 2.55e-16 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.9 12.86 0.58 4.98e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg12310025 chr6:25882481 NA -0.63 -10.68 -0.5 4.07e-23 Blood metabolite levels; LUSC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg20587970 chr11:113659929 NA 1.06 13.37 0.59 6.16e-33 Hip circumference adjusted for BMI; LUSC cis rs727505 1.000 rs113394869 chr7:124518172 G/C cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs9309473 0.583 rs6718864 chr2:73574591 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.29 -0.37 2.26e-12 Metabolite levels; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.53 0.38 4.8e-13 Bipolar disorder; LUSC cis rs9527 0.590 rs10883836 chr10:104891198 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs7119167 0.686 rs7933162 chr11:73044213 A/C cg17517138 chr11:73019481 ARHGEF17 0.49 5.71 0.3 2.49e-8 Blood protein levels; LUSC cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg13010199 chr12:38710504 ALG10B 0.65 9.9 0.48 1.96e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg17554472 chr22:41940697 POLR3H 0.47 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs1419980 0.673 rs10845432 chr12:7728131 T/C cg10578777 chr12:7781093 NA 0.54 5.71 0.3 2.48e-8 HDL cholesterol levels; LUSC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg16447950 chr5:562315 NA -0.59 -7.08 -0.36 8.54e-12 Lung disease severity in cystic fibrosis; LUSC trans rs9329221 0.686 rs35406700 chr8:10244593 A/G cg15556689 chr8:8085844 FLJ10661 0.63 9.08 0.44 9.73e-18 Neuroticism; LUSC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg19824325 chr16:58548873 SETD6 0.94 9.13 0.45 6.5e-18 Schizophrenia; LUSC cis rs11785693 0.862 rs17435605 chr8:4987302 A/G cg26367366 chr8:4980734 NA 0.76 9.07 0.44 1e-17 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs58688157 0.960 rs1061502 chr11:614318 T/C cg15790184 chr11:494944 RNH1 0.42 6.4 0.33 5.37e-10 Systemic lupus erythematosus; LUSC cis rs9549367 0.865 rs3861721 chr13:113906308 C/T cg18105134 chr13:113819100 PROZ -0.68 -9.66 -0.47 1.24e-19 Platelet distribution width; LUSC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg06008330 chr7:65541103 ASL -0.41 -6.3 -0.33 9.65e-10 Aortic root size; LUSC cis rs16976116 0.901 rs28564077 chr15:55495151 G/A cg11288833 chr15:55489084 RSL24D1 0.49 5.8 0.3 1.53e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg20243544 chr17:37824526 PNMT 0.39 5.96 0.31 6.31e-9 Self-reported allergy; LUSC cis rs10203711 1.000 rs907102 chr2:239564503 G/A cg14580085 chr2:239553406 NA 0.41 6.96 0.36 1.76e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2806561 0.780 rs12751560 chr1:23407081 C/A cg19743168 chr1:23544995 NA -0.44 -9.06 -0.44 1.15e-17 Height; LUSC trans rs1922233 1.000 rs1997497 chr4:92365182 C/T cg24250684 chr1:219729030 NA -0.33 -6.54 -0.34 2.26e-10 Gut microbiome composition (summer and winter); LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.08 0.52 1.69e-24 Prudent dietary pattern; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.58 -7.85 -0.39 5.82e-14 Renal function-related traits (BUN); LUSC cis rs2734839 1.000 rs2734839 chr11:113286490 C/T cg14159747 chr11:113255604 NA 0.26 6.56 0.34 2.1e-10 Information processing speed; LUSC cis rs1348850 0.793 rs13027299 chr2:178455501 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.88 0.31 9.93e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg01819759 chr13:79234251 RNF219 0.6 8.09 0.4 1.14e-14 Large artery stroke; LUSC cis rs977987 0.771 rs12929673 chr16:75470295 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.11 -0.36 7.07e-12 Dupuytren's disease; LUSC cis rs11792861 0.816 rs3818932 chr9:111664178 T/C cg13535736 chr9:111863775 C9orf5 -0.38 -6.08 -0.32 3.3e-9 Menarche (age at onset); LUSC cis rs7011049 1.000 rs7011049 chr8:53834012 C/A cg26025543 chr8:53854495 NA 0.51 6.3 0.33 9.53e-10 Systolic blood pressure; LUSC cis rs694739 0.930 rs574087 chr11:64102948 A/G cg23796481 chr11:64053134 BAD;GPR137 0.59 9.68 0.47 1.06e-19 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs1784581 0.588 rs6455789 chr6:162417948 C/T cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.09e-20 Itch intensity from mosquito bite; LUSC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg12016809 chr21:47604291 C21orf56 -0.43 -6.54 -0.34 2.27e-10 Testicular germ cell tumor; LUSC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg03036452 chr22:46663545 TTC38 0.53 5.76 0.3 1.89e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs727505 0.789 rs4731233 chr7:124736291 C/T cg23710748 chr7:124431027 NA -0.4 -7.04 -0.36 1.08e-11 Lewy body disease; LUSC cis rs1538970 1.000 rs11211101 chr1:45849311 C/G cg06784218 chr1:46089804 CCDC17 0.32 6.02 0.31 4.55e-9 Platelet count; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.22 0.41 4.51e-15 Prudent dietary pattern; LUSC cis rs1003719 0.788 rs2835577 chr21:38457457 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.46 0.53 7.16e-26 Eye color traits; LUSC cis rs763014 1.000 rs763014 chr16:675680 T/C cg07343612 chr16:622815 PIGQ -0.73 -12.32 -0.56 5.16e-29 Height; LUSC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg00750074 chr16:89608354 SPG7 -0.47 -8.18 -0.41 6.05e-15 Multiple myeloma (IgH translocation); LUSC cis rs7246967 0.673 rs4932784 chr19:22874251 A/C cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.86 -0.35 3.4e-11 Monocyte percentage of white cells; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg17520314 chr17:79604207 NPLOC4 -0.48 -7.03 -0.36 1.18e-11 Cognitive function;Information processing speed; LUSC trans rs453301 0.507 rs2929306 chr8:9084909 C/T cg21775007 chr8:11205619 TDH -0.45 -6.36 -0.33 6.81e-10 Joint mobility (Beighton score); LUSC cis rs6665290 0.904 rs1045252 chr1:227181555 A/G cg10327440 chr1:227177885 CDC42BPA -1.21 -39.82 -0.91 6.98e-129 Myeloid white cell count; LUSC cis rs7572644 0.679 rs4419196 chr2:28075298 A/G cg27432699 chr2:27873401 GPN1 0.52 6.95 0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7582720 0.943 rs72926798 chr2:203827675 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg13395646 chr4:1353034 KIAA1530 -0.54 -8.58 -0.42 3.74e-16 Obesity-related traits; LUSC cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg04414720 chr1:150670196 GOLPH3L -0.44 -7.05 -0.36 1.05e-11 Tonsillectomy; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg07934232 chr19:36619082 NA 0.41 6.41 0.33 4.97e-10 Schizophrenia (age at onset); LUSC cis rs10504073 0.647 rs9643395 chr8:50014500 A/C cg00325661 chr8:49890786 NA 0.62 10.4 0.49 3.99e-22 Blood metabolite ratios; LUSC cis rs7605827 0.930 rs2287264 chr2:15637592 C/G cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.74e-17 Educational attainment (years of education); LUSC cis rs9486719 0.843 rs3849198 chr6:97036539 C/A cg06623918 chr6:96969491 KIAA0776 -0.84 -10.4 -0.49 3.86e-22 Migraine;Coronary artery disease; LUSC cis rs6835098 0.608 rs2332668 chr4:174163360 A/G cg08422745 chr4:174089978 GALNT7 -0.73 -11.76 -0.54 5.78e-27 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs11105298 0.891 rs11105312 chr12:89920733 C/T cg00757033 chr12:89920650 WDR51B 0.59 10.45 0.5 2.65e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs7980799 0.649 rs11052732 chr12:33657801 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.17 -0.32 1.99e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs6952808 0.636 rs6964522 chr7:1953523 C/T cg04565464 chr8:145669602 NFKBIL2 0.38 6.35 0.33 7.15e-10 Bipolar disorder and schizophrenia; LUSC cis rs9902453 0.967 rs4356528 chr17:28489670 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.08 0.4 1.24e-14 Coffee consumption (cups per day); LUSC cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs79839061 0.610 rs73207794 chr4:872020 T/C cg23992470 chr4:843637 GAK 0.6 6.45 0.33 3.98e-10 Intelligence (multi-trait analysis); LUSC trans rs7094131 0.542 rs7071306 chr10:22867339 A/G cg00377074 chr6:134159127 MGC34034 0.4 6.29 0.33 1e-9 Obesity-related traits; LUSC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg08085267 chr17:45401833 C17orf57 -0.46 -6.58 -0.34 1.82e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1577917 0.883 rs12214536 chr6:86790310 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.18e-11 Response to antipsychotic treatment; LUSC cis rs7712401 0.642 rs17388251 chr5:122360403 C/T cg19077854 chr5:122220652 SNX24 0.34 7.51 0.38 5.47e-13 Mean platelet volume; LUSC cis rs9611565 0.546 rs5758426 chr22:42098763 T/G cg03806693 chr22:41940476 POLR3H 0.91 13.27 0.59 1.41e-32 Vitiligo; LUSC cis rs10876993 0.890 rs1092472 chr12:58036688 G/T cg18357645 chr12:58087776 OS9 0.49 7.3 0.37 2.17e-12 Celiac disease or Rheumatoid arthritis; LUSC cis rs11122272 0.735 rs2250734 chr1:231485958 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.19 -0.49 2.05e-21 Hemoglobin concentration; LUSC cis rs17270561 0.609 rs6924782 chr6:25735816 C/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs11971779 0.648 rs28754644 chr7:139065057 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs637571 0.510 rs10896052 chr11:65579600 C/A cg26695010 chr11:65641043 EFEMP2 0.44 6.42 0.33 4.77e-10 Eosinophil percentage of white cells; LUSC trans rs7939886 0.920 rs11231821 chr11:55777052 C/G cg03929089 chr4:120376271 NA 0.79 6.79 0.35 5.1e-11 Myopia (pathological); LUSC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg08886695 chr4:3369023 RGS12 -0.37 -6.08 -0.32 3.37e-9 Parental longevity (mother's age at death); LUSC cis rs637571 0.544 rs617791 chr11:65702523 C/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 7.79 0.39 8.39e-14 Eosinophil percentage of white cells; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg13012494 chr21:47604986 C21orf56 -0.51 -7.81 -0.39 7.43e-14 Testicular germ cell tumor; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg18404041 chr3:52824283 ITIH1 -0.56 -10.63 -0.5 6.41e-23 Bipolar disorder; LUSC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg23887609 chr12:130822674 PIWIL1 -0.48 -7.11 -0.36 6.92e-12 Menopause (age at onset); LUSC cis rs7681440 0.874 rs1372523 chr4:90775923 G/A cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.31 1.15e-8 Dementia with Lewy bodies; LUSC cis rs59698941 0.943 rs67860107 chr5:132276825 G/C cg02081065 chr5:132209139 LEAP2 -0.64 -6.66 -0.34 1.1e-10 Apolipoprotein A-IV levels; LUSC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg05340658 chr4:99064831 C4orf37 0.65 10.99 0.52 3.31e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.909 rs1546504 chr4:120241179 C/T cg24375607 chr4:120327624 NA 0.79 11.44 0.53 8.43e-26 Corneal astigmatism; LUSC cis rs7020830 0.830 rs17487601 chr9:37213641 G/A cg14294708 chr9:37120828 ZCCHC7 1.08 24.0 0.8 1.12e-74 Schizophrenia; LUSC cis rs941898 0.836 rs7158754 chr14:100583349 A/G cg26002632 chr14:100625216 DEGS2 -0.31 -5.69 -0.3 2.71e-8 White matter hyperintensity burden; LUSC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.71 -6.79 -0.35 5.16e-11 Cerebrospinal P-tau181p levels; LUSC cis rs7267979 1.000 rs2500418 chr20:25382268 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.66 -0.34 1.14e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7020830 0.898 rs6476617 chr9:37200103 G/A cg14294708 chr9:37120828 ZCCHC7 1.04 23.43 0.79 1.79e-72 Schizophrenia; LUSC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg21433313 chr16:3507492 NAT15 0.79 9.77 0.47 5.34e-20 Tuberculosis; LUSC cis rs4631830 0.832 rs1585378 chr10:51523213 A/T cg20129853 chr10:51489980 NA -0.34 -6.98 -0.36 1.58e-11 Prostate-specific antigen levels; LUSC cis rs61931739 0.500 rs10772154 chr12:34373271 A/C cg06521331 chr12:34319734 NA -0.43 -7.07 -0.36 9.25e-12 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25634484 chr8:8559074 CLDN23 0.48 7.93 0.4 3.25e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1864729 1.000 rs2853320 chr8:98283523 C/G cg08679828 chr8:102218111 ZNF706 -0.85 -7.71 -0.39 1.45e-13 Estradiol plasma levels (breast cancer); LUSC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg05082376 chr22:42548792 NA 0.43 6.89 0.35 2.85e-11 Schizophrenia; LUSC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg18904891 chr8:8559673 CLDN23 0.58 8.07 0.4 1.25e-14 Obesity-related traits; LUSC cis rs6733011 0.578 rs12712039 chr2:99497980 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -5.74 -0.3 2.17e-8 Bipolar disorder; LUSC trans rs1499614 1.000 rs1638731 chr7:66144679 C/T cg10756647 chr7:56101905 PSPH 0.85 8.45 0.42 8.99e-16 Gout; LUSC cis rs1847202 1.000 rs6807627 chr3:72939767 C/T cg25664220 chr3:72788482 NA -0.35 -6.58 -0.34 1.8e-10 Motion sickness; LUSC trans rs3960554 0.599 rs56090527 chr7:75762125 A/C cg19862616 chr7:65841803 NCRNA00174 0.9 10.2 0.49 1.89e-21 Eotaxin levels; LUSC cis rs9807989 0.507 rs11465721 chr2:103063240 T/G cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.01e-12 Asthma; LUSC cis rs909002 0.849 rs4949449 chr1:32088534 T/G cg01639898 chr1:32083012 HCRTR1 0.28 6.41 0.33 5.05e-10 Intelligence (multi-trait analysis); LUSC cis rs72781680 0.898 rs12623316 chr2:24087857 A/G cg08917208 chr2:24149416 ATAD2B 0.87 9.86 0.47 2.6e-20 Lymphocyte counts; LUSC cis rs1113500 0.787 rs10881502 chr1:108641819 C/T cg06207961 chr1:108661230 NA -0.31 -5.83 -0.3 1.32e-8 Growth-regulated protein alpha levels; LUSC cis rs73198271 0.601 rs11997731 chr8:8649848 C/T cg01851573 chr8:8652454 MFHAS1 0.53 8.51 0.42 5.95e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs4332037 0.851 rs73050128 chr7:1961882 C/A cg11693508 chr17:37793320 STARD3 0.66 8.19 0.41 5.46e-15 Bipolar disorder; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg07677032 chr17:61819896 STRADA 0.55 8.93 0.44 2.91e-17 Prudent dietary pattern; LUSC cis rs4842666 0.765 rs4842675 chr12:90075243 C/T cg00757033 chr12:89920650 WDR51B 0.49 7.05 0.36 1.02e-11 Blood pressure; LUSC cis rs796364 0.806 rs35200468 chr2:201110368 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -7.27 -0.37 2.6e-12 Schizophrenia; LUSC cis rs11711311 1.000 rs9811200 chr3:113531180 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.79 0.35 5.23e-11 IgG glycosylation; LUSC cis rs12458462 0.859 rs2242177 chr18:77477379 G/A cg11879182 chr18:77439856 CTDP1 0.73 11.86 0.54 2.66e-27 Monocyte count; LUSC cis rs2204008 0.678 rs61929520 chr12:38446800 T/C cg26384229 chr12:38710491 ALG10B -0.54 -8.17 -0.41 6.62e-15 Bladder cancer; LUSC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg19920283 chr7:105172520 RINT1 0.61 6.62 0.34 1.42e-10 Bipolar disorder (body mass index interaction); LUSC cis rs146201400 1 rs146201400 chr1:26645955 G/GA cg04990556 chr1:26633338 UBXN11 -0.48 -6.12 -0.32 2.64e-9 Monocyte percentage of white cells; LUSC cis rs9811920 0.809 rs793437 chr3:99559854 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.41 -6.01 -0.31 4.77e-9 Axial length; LUSC cis rs9388451 0.772 rs1268064 chr6:126042578 G/A cg10911889 chr6:126070802 HEY2 -0.38 -5.87 -0.31 1.04e-8 Brugada syndrome; LUSC cis rs8060686 0.641 rs7201742 chr16:68099821 T/G cg26727032 chr16:67993705 SLC12A4 -0.42 -5.8 -0.3 1.55e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.4 0.69 1.03e-48 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6120849 0.754 rs3746436 chr20:33586193 C/T cg24642439 chr20:33292090 TP53INP2 0.63 6.91 0.35 2.47e-11 Protein C levels; LUSC cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.28 0.56 7.44e-29 Motion sickness; LUSC cis rs4363385 0.818 rs451939 chr1:153006877 C/T cg00922841 chr1:152955080 SPRR1A -0.4 -7.07 -0.36 9.08e-12 Inflammatory skin disease; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg16145915 chr7:1198662 ZFAND2A -0.63 -11.72 -0.54 8.13e-27 Longevity;Endometriosis; LUSC cis rs1801251 1.000 rs283479 chr2:233648754 A/G cg08000102 chr2:233561755 GIGYF2 0.75 11.78 0.54 4.88e-27 Coronary artery disease; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg09184467 chr10:14995699 DCLRE1C -0.48 -6.31 -0.33 8.62e-10 Height; LUSC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg24692254 chr21:30365293 RNF160 -0.73 -11.19 -0.52 6.62e-25 Pancreatic cancer; LUSC cis rs12310956 0.532 rs1525897 chr12:33941033 C/T cg06521331 chr12:34319734 NA -0.45 -7.26 -0.37 2.82e-12 Morning vs. evening chronotype; LUSC cis rs9905704 0.681 rs887206 chr17:56575084 G/C cg12560992 chr17:57184187 TRIM37 -0.5 -5.84 -0.3 1.21e-8 Testicular germ cell tumor; LUSC cis rs16937 0.518 rs1172149 chr1:205224758 A/G cg21643547 chr1:205240462 TMCC2 -0.37 -6.72 -0.34 8.05e-11 Schizophrenia; LUSC cis rs7246967 0.673 rs2361021 chr19:22816324 T/G cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs2075371 0.501 rs1646652 chr7:134024515 A/T cg11752832 chr7:134001865 SLC35B4 0.4 6.07 0.32 3.45e-9 Mean platelet volume; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg20887711 chr4:1340912 KIAA1530 0.44 6.62 0.34 1.46e-10 Obesity-related traits; LUSC cis rs3125734 0.633 rs1368157 chr10:64001114 T/C cg19640130 chr10:64028056 RTKN2 -0.39 -7.02 -0.36 1.22e-11 Rheumatoid arthritis; LUSC cis rs4595586 0.545 rs58154430 chr12:39386649 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.36 0.37 1.42e-12 Morning vs. evening chronotype; LUSC cis rs2573652 0.674 rs11630619 chr15:100543367 G/A cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.32 -0.33 8.59e-10 Height; LUSC cis rs7508 0.511 rs2237853 chr8:17877880 G/A cg01800426 chr8:17659068 MTUS1 -0.57 -6.98 -0.36 1.61e-11 Atrial fibrillation; LUSC cis rs73206853 0.563 rs56386451 chr12:111174516 A/G cg12870014 chr12:110450643 ANKRD13A 0.69 6.67 0.34 1.08e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.42 0.38 9.54e-13 Alzheimer's disease; LUSC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg05729581 chr11:3078854 CARS -0.57 -8.85 -0.44 5.31e-17 Longevity; LUSC cis rs72781680 0.898 rs7569424 chr2:24036222 A/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC trans rs9755467 0.665 rs57706556 chr3:127181579 T/A cg22395942 chr19:2354559 SPPL2B 0.43 6.38 0.33 5.77e-10 Educational attainment (years of education); LUSC cis rs7917772 0.582 rs7087984 chr10:104380686 G/A cg22532475 chr10:104410764 TRIM8 -0.26 -6.06 -0.31 3.67e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs208520 0.909 rs9345809 chr6:67017543 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 8.87 0.44 4.63e-17 Exhaled nitric oxide output; LUSC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.82 -0.3 1.42e-8 Depression; LUSC trans rs637571 0.522 rs12797319 chr11:65735672 G/A cg17712092 chr4:129076599 LARP1B 0.82 12.34 0.56 4.47e-29 Eosinophil percentage of white cells; LUSC trans rs35110281 0.805 rs2838317 chr21:44991791 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.62 0.47 1.76e-19 Mean corpuscular volume; LUSC trans rs6561151 0.681 rs17065161 chr13:44443723 A/T cg12856521 chr11:46389249 DGKZ 0.73 9.82 0.47 3.73e-20 Crohn's disease; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg12564285 chr5:131593104 PDLIM4 0.53 9.68 0.47 1.08e-19 Acylcarnitine levels; LUSC cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg22709100 chr7:91322751 NA 0.4 5.79 0.3 1.62e-8 Breast cancer; LUSC cis rs6500395 1.000 rs12599744 chr16:48716729 G/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg24733560 chr20:60626293 TAF4 0.4 6.4 0.33 5.12e-10 Body mass index; LUSC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.99 0.4 2.24e-14 Bipolar disorder; LUSC trans rs853679 0.607 rs34243448 chr6:28193102 C/A cg06606381 chr12:133084897 FBRSL1 -1.08 -9.48 -0.46 5e-19 Depression; LUSC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg06915202 chr7:98029285 BAIAP2L1 0.32 6.39 0.33 5.7e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg26597838 chr10:835615 NA 0.79 9.74 0.47 6.95e-20 Eosinophil percentage of granulocytes; LUSC cis rs8062405 0.824 rs4788083 chr16:28545449 A/G cg16576597 chr16:28551801 NUPR1 0.29 5.82 0.3 1.36e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs6089829 0.962 rs3746747 chr20:61667631 T/C cg15934090 chr1:100435551 SLC35A3 0.49 8.32 0.41 2.32e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs113835537 0.529 rs3179961 chr11:66244454 A/G cg24851651 chr11:66362959 CCS 0.53 8.15 0.41 7.43e-15 Airway imaging phenotypes; LUSC cis rs12210905 0.925 rs12214640 chr6:26762080 G/A cg11502198 chr6:26597334 ABT1 -0.74 -5.7 -0.3 2.59e-8 Hip circumference adjusted for BMI; LUSC cis rs9311676 0.656 rs62258127 chr3:58397102 G/A cg26110898 chr3:58419937 PDHB 0.4 6.48 0.33 3.27e-10 Systemic lupus erythematosus; LUSC cis rs701145 0.529 rs355759 chr3:154008078 G/C cg17054900 chr3:154042577 DHX36 0.44 5.75 0.3 2.01e-8 Coronary artery disease; LUSC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12667521 chr19:29218732 NA 0.59 9.0 0.44 1.77e-17 Methadone dose in opioid dependence; LUSC cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg04944784 chr2:26401820 FAM59B -0.68 -9.45 -0.46 6.2800000000000005e-19 Gut microbiome composition (summer); LUSC cis rs7824557 0.564 rs34389419 chr8:11229319 C/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.47e-10 Retinal vascular caliber; LUSC cis rs12627970 0.565 rs2072872 chr22:39713128 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.82 15.16 0.64 7.52e-40 Inflammatory bowel disease; LUSC cis rs2677744 1.000 rs1266489 chr15:91458485 G/A cg00526711 chr15:91477898 UNC45A 0.31 6.18 0.32 1.87e-9 Attention deficit hyperactivity disorder; LUSC cis rs12586317 0.620 rs8020370 chr14:35581432 G/A cg05294307 chr14:35346193 BAZ1A -0.57 -7.0 -0.36 1.39e-11 Psoriasis; LUSC trans rs7726839 0.540 rs72703083 chr5:595365 C/T cg11887960 chr12:57824829 NA 0.54 6.8 0.35 4.89e-11 Obesity-related traits; LUSC trans rs2262909 1.000 rs2359821 chr19:22208314 C/T cg05197062 chr11:11642011 GALNTL4 -0.51 -7.08 -0.36 8.34e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7647973 0.696 rs7100 chr3:49053219 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.66 9.7 0.47 9.19e-20 Menarche (age at onset); LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg15242686 chr22:24348715 GSTTP1 0.42 6.23 0.32 1.44e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs8040855 0.894 rs4843023 chr15:85705872 A/C cg00988175 chr11:59481031 OR10V1 -0.3 -6.38 -0.33 5.96e-10 Bulimia nervosa; LUSC cis rs4629180 0.651 rs9653468 chr2:102108403 A/G cg01388757 chr2:102091195 RFX8 -0.34 -5.9 -0.31 8.84e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg08219700 chr8:58056026 NA 0.5 6.59 0.34 1.67e-10 Developmental language disorder (linguistic errors); LUSC cis rs2439831 0.850 rs8032649 chr15:44134922 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.7 -6.62 -0.34 1.41e-10 Lung cancer in ever smokers; LUSC cis rs13082711 0.911 rs2172298 chr3:27425611 T/C cg02860705 chr3:27208620 NA 0.48 7.99 0.4 2.27e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg03161606 chr19:29218774 NA 0.56 6.85 0.35 3.64e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg27539214 chr16:67997921 SLC12A4 -0.57 -7.54 -0.38 4.58e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.45 -8.34 -0.42 1.94e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.47 8.37 0.42 1.58e-15 Total body bone mineral density; LUSC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg16520312 chr17:43971471 MAPT;LOC100128977 0.38 6.51 0.34 2.7e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7223966 1.000 rs55674647 chr17:61794195 T/C cg00945038 chr17:61921165 SMARCD2 0.4 5.81 0.3 1.49e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg08807101 chr21:30365312 RNF160 -0.5 -7.39 -0.37 1.21e-12 Dental caries; LUSC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg00383909 chr3:49044727 WDR6 0.42 5.71 0.3 2.51e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6835098 0.962 rs6851632 chr4:174109611 A/G cg08422745 chr4:174089978 GALNT7 -0.8 -12.96 -0.58 2.11e-31 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs3818285 0.610 rs642938 chr10:111633025 A/C cg00817464 chr10:111662876 XPNPEP1 0.71 12.54 0.57 7.86e-30 Superior crus of antihelix expression; LUSC cis rs9611565 0.921 rs5751081 chr22:41742788 A/T cg03806693 chr22:41940476 POLR3H -0.72 -10.68 -0.5 4.22e-23 Vitiligo; LUSC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg18850127 chr7:39170497 POU6F2 0.68 11.0 0.52 3.13e-24 IgG glycosylation; LUSC cis rs2901656 0.502 rs9425602 chr1:172383686 T/A cg03748243 chr1:172413542 C1orf105;PIGC -0.3 -5.79 -0.3 1.66e-8 Red cell distribution width;Platelet distribution width; LUSC cis rs950027 0.549 rs12909409 chr15:45608582 T/G cg09092052 chr15:45571596 NA 0.5 7.0 0.36 1.44e-11 Response to fenofibrate (adiponectin levels); LUSC cis rs2730245 1.000 rs2657345 chr7:158744169 T/C cg11984989 chr7:158649758 WDR60 -1.01 -17.18 -0.68 7.65e-48 Height; LUSC cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg15073853 chr19:18549131 ISYNA1 -0.32 -5.92 -0.31 8.1e-9 Breast cancer; LUSC cis rs9400467 0.508 rs12211763 chr6:111787156 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.32 -0.33 8.41e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs12541635 0.639 rs6469030 chr8:107030321 C/T cg10147462 chr8:107024639 NA 0.66 13.79 0.6 1.53e-34 Age of smoking initiation; LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg19318889 chr4:1322082 MAEA 0.58 9.99 0.48 9.81e-21 Longevity; LUSC cis rs1577917 1.000 rs12205336 chr6:86722367 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.08 -0.36 8.81e-12 Response to antipsychotic treatment; LUSC cis rs11756438 0.572 rs1771756 chr6:119018502 C/T cg18833306 chr6:118973337 C6orf204 0.38 6.0 0.31 5.25e-9 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2769264 0.649 rs9436029 chr1:151367378 C/T cg18801370 chr1:151430492 POGZ -0.96 -8.56 -0.42 4.05e-16 Blood trace element (Cu levels); LUSC cis rs17270561 0.666 rs4711099 chr6:25741809 C/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs1375194 0.606 rs2044644 chr2:33817559 A/G cg04131969 chr2:33951647 MYADML -0.61 -8.47 -0.42 7.87e-16 Response to antidepressants in depression; LUSC cis rs3750965 1.000 rs731974 chr11:68847156 C/T cg06818126 chr11:68850279 TPCN2 -0.45 -6.45 -0.33 3.92e-10 Hair color; LUSC cis rs7267979 1.000 rs1888997 chr20:25298988 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.0 -0.7 4.16e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs983392 0.709 rs4492839 chr11:59986399 T/A cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs2486288 0.656 rs11632724 chr15:45550791 G/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.02e-14 Glomerular filtration rate; LUSC cis rs4820318 1 rs4820318 chr22:38570313 G/A cg25457927 chr22:38595422 NA -0.37 -7.56 -0.38 3.8e-13 Breast cancer; LUSC cis rs9612 1.000 rs346545 chr19:44256386 T/C cg08581076 chr19:44259116 C19orf61 0.53 6.71 0.34 8.22e-11 Exhaled nitric oxide output; LUSC cis rs854765 0.583 rs9913724 chr17:17819101 A/G cg09796270 chr17:17721594 SREBF1 0.43 7.63 0.39 2.41e-13 Total body bone mineral density; LUSC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.85 0.66 1.36e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7615952 0.546 rs2979338 chr3:125343126 G/T cg05084668 chr3:125655381 ALG1L -0.45 -6.02 -0.31 4.67e-9 Blood pressure (smoking interaction); LUSC trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg03929089 chr4:120376271 NA 0.64 6.06 0.31 3.65e-9 Intraocular pressure; LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg11843238 chr5:131593191 PDLIM4 0.44 7.73 0.39 1.28e-13 Blood metabolite levels; LUSC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.0 0.48 8.89e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.863 rs3775843 chr4:120427844 T/C cg09307838 chr4:120376055 NA 0.76 11.09 0.52 1.5e-24 Corneal astigmatism; LUSC cis rs35146811 0.625 rs858514 chr7:99825748 A/G cg13334819 chr7:99746414 C7orf59 0.49 6.56 0.34 2.05e-10 Coronary artery disease; LUSC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.63 -10.17 -0.49 2.48e-21 Menarche (age at onset); LUSC cis rs1788820 0.917 rs1788819 chr18:21100504 G/A cg14672496 chr18:21087552 C18orf8 0.44 6.92 0.35 2.33e-11 Body mass index; LUSC cis rs75804782 0.521 rs72993065 chr2:239409001 C/T cg18131467 chr2:239335373 ASB1 -0.72 -6.36 -0.33 6.59e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs3774830 0.743 rs11728680 chr4:5462247 A/G cg26943120 chr4:5472116 STK32B 0.31 6.12 0.32 2.59e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs911555 0.617 rs7156036 chr14:103908142 A/G cg24130564 chr14:104152367 KLC1 0.45 6.53 0.34 2.43e-10 Intelligence (multi-trait analysis); LUSC cis rs10782582 0.593 rs114421765 chr1:76141802 C/T cg22875332 chr1:76189707 ACADM -0.4 -5.9 -0.31 8.71e-9 Daytime sleep phenotypes; LUSC cis rs1448094 0.785 rs7955173 chr12:86447214 G/A cg02569458 chr12:86230093 RASSF9 -0.36 -5.76 -0.3 1.87e-8 Major depressive disorder; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg05863683 chr7:1912471 MAD1L1 0.3 5.66 0.3 3.24e-8 Bipolar disorder and schizophrenia; LUSC cis rs684232 0.666 rs366151 chr17:598311 A/C cg15660573 chr17:549704 VPS53 -0.68 -11.63 -0.54 1.74e-26 Prostate cancer; LUSC trans rs72674100 1.000 rs61291954 chr4:97971955 C/T cg09670535 chr1:18959427 PAX7 -0.56 -5.99 -0.31 5.44e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs28595532 0.748 rs72670249 chr4:119336823 G/T cg21605333 chr4:119757512 SEC24D 1.02 8.31 0.41 2.47e-15 Cannabis dependence symptom count; LUSC cis rs11785400 0.793 rs4736366 chr8:143742413 C/T cg24634471 chr8:143751801 JRK 0.53 7.47 0.38 7.03e-13 Schizophrenia; LUSC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.08 0.32 3.34e-9 Menopause (age at onset); LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg17551891 chr7:1960795 MAD1L1 -0.31 -5.69 -0.3 2.79e-8 Bipolar disorder and schizophrenia; LUSC cis rs12594515 0.967 rs11070466 chr15:45984955 C/T cg01629716 chr15:45996671 NA 0.4 6.08 0.32 3.26e-9 Waist circumference;Weight; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.52 0.76 4.6e-65 Prudent dietary pattern; LUSC cis rs10979 0.838 rs12208649 chr6:143893321 G/T cg25407410 chr6:143891975 LOC285740 -0.74 -12.23 -0.56 1.14e-28 Hypospadias; LUSC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg04155289 chr7:94953770 PON1 -0.35 -6.07 -0.32 3.38e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6964587 1.000 rs7785095 chr7:91640773 A/T cg22117172 chr7:91764530 CYP51A1 -0.31 -5.65 -0.3 3.51e-8 Breast cancer; LUSC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg21724239 chr8:58056113 NA 0.57 6.6 0.34 1.61e-10 Developmental language disorder (linguistic errors); LUSC cis rs2228479 0.681 rs62052184 chr16:89967217 T/C cg00800038 chr16:89945340 TCF25 -0.64 -6.72 -0.35 7.69e-11 Skin colour saturation; LUSC cis rs662064 0.748 rs12375 chr1:10596341 C/T cg20482658 chr1:10539492 PEX14 0.32 6.45 0.33 3.89e-10 Asthma; LUSC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -9.91 -0.48 1.83e-20 Developmental language disorder (linguistic errors); LUSC cis rs79349575 0.783 rs4793992 chr17:47008207 A/G cg22482690 chr17:47019901 SNF8 0.41 7.7 0.39 1.56e-13 Type 2 diabetes; LUSC cis rs8072100 0.640 rs3851808 chr17:45425144 C/T cg08085267 chr17:45401833 C17orf57 -0.5 -7.21 -0.37 3.76e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3617 0.539 rs9825369 chr3:52953311 T/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.35 -5.65 -0.3 3.38e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg06219351 chr7:158114137 PTPRN2 -0.52 -9.45 -0.46 5.96e-19 Calcium levels; LUSC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.98 -0.31 5.8e-9 Life satisfaction; LUSC cis rs10740039 0.810 rs10761528 chr10:62367660 A/G cg18175470 chr10:62150864 ANK3 -0.46 -7.08 -0.36 8.3e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs877282 0.755 rs1769242 chr10:787896 T/C cg17470449 chr10:769945 NA 0.41 6.06 0.31 3.62e-9 Uric acid levels; LUSC cis rs11608355 0.521 rs10850131 chr12:109837052 A/G cg19025524 chr12:109796872 NA 0.39 7.25 0.37 2.99e-12 Neuroticism; LUSC cis rs12474201 0.507 rs6714451 chr2:47017743 G/C cg06386533 chr2:46925753 SOCS5 0.47 6.78 0.35 5.4e-11 Height; LUSC cis rs7107174 0.901 rs2511162 chr11:77927101 A/G cg02023728 chr11:77925099 USP35 0.46 6.73 0.35 7.19e-11 Testicular germ cell tumor; LUSC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg23649088 chr2:200775458 C2orf69 0.78 14.38 0.62 7.93e-37 Osteoporosis; LUSC cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg21535247 chr6:8435926 SLC35B3 0.57 9.0 0.44 1.69e-17 Motion sickness; LUSC cis rs12681288 0.523 rs11137122 chr8:954702 A/G cg15309053 chr8:964076 NA 0.42 8.69 0.43 1.6e-16 Schizophrenia; LUSC cis rs6598955 0.543 rs881578 chr1:26536141 G/A cg04990556 chr1:26633338 UBXN11 0.85 11.14 0.52 9.76e-25 Obesity-related traits; LUSC cis rs66716358 0.800 rs4755809 chr11:44323193 A/G cg02785814 chr11:44338707 NA -0.41 -6.26 -0.32 1.19e-9 Monobrow; LUSC cis rs2273669 0.667 rs12206834 chr6:109303967 T/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.69 0.6 3.62e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg02782426 chr3:40428986 ENTPD3 0.34 6.44 0.33 4.16e-10 Renal cell carcinoma; LUSC trans rs62103177 0.564 rs1715230 chr18:77848002 C/T cg14227996 chr4:17616232 MED28 0.55 6.21 0.32 1.55e-9 Opioid sensitivity; LUSC cis rs965469 0.895 rs6139123 chr20:3396634 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -5.64 -0.3 3.57e-8 IFN-related cytopenia; LUSC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg24733560 chr20:60626293 TAF4 0.41 6.69 0.34 9.26e-11 Body mass index; LUSC cis rs10779751 0.610 rs2486921 chr1:11124943 G/A cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs1866706 0.896 rs7119811 chr11:12882376 T/G cg25843174 chr11:12811716 TEAD1 0.28 5.82 0.3 1.37e-8 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.04 -0.36 1.07e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4746822 0.815 rs10823318 chr10:70979924 A/T cg14418922 chr10:70824840 NA -0.38 -6.29 -0.33 1.01e-9 Glycemic traits (pregnancy); LUSC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -8.46 -0.42 8.33e-16 Personality dimensions; LUSC cis rs2235642 0.785 rs1057983 chr16:1660274 A/G cg26528668 chr16:1614120 IFT140 0.42 7.2 0.37 3.97e-12 Coronary artery disease; LUSC cis rs11190604 1.000 rs2495760 chr10:102318771 T/C cg16342193 chr10:102329863 NA -0.41 -6.78 -0.35 5.57e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9527 0.590 rs12785223 chr10:104844011 C/T cg05855489 chr10:104503620 C10orf26 -0.53 -8.07 -0.4 1.25e-14 Arsenic metabolism; LUSC cis rs12286929 0.839 rs12790574 chr11:115009145 C/T cg04055981 chr11:115044050 NA 0.34 5.78 0.3 1.76e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg15934090 chr1:100435551 SLC35A3 0.47 8.08 0.4 1.21e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs11626933 1.000 rs2236402 chr14:90734378 C/G cg14092571 chr14:90743983 NA -0.89 -18.73 -0.72 4.96e-54 Gut microbiota (bacterial taxa); LUSC cis rs9303401 0.527 rs34835800 chr17:56764990 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.17 0.58 3.55e-32 Cognitive test performance; LUSC cis rs6163 0.588 rs10786706 chr10:104500659 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.48 -7.24 -0.37 3.19e-12 Waist circumference;Hip circumference; LUSC cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg08213375 chr14:104286397 PPP1R13B 0.52 10.19 0.49 2.08e-21 Schizophrenia; LUSC cis rs40363 1.000 rs28401 chr16:3515354 C/G cg00484396 chr16:3507460 NAT15 0.85 11.31 0.53 2.56e-25 Tuberculosis; LUSC trans rs1997103 0.954 rs6593236 chr7:55410992 C/T cg20935933 chr6:143382018 AIG1 0.51 7.38 0.37 1.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs240764 0.658 rs705584 chr6:101261553 C/T cg09795085 chr6:101329169 ASCC3 0.43 6.26 0.32 1.18e-9 Neuroticism; LUSC cis rs7493 0.950 rs7802171 chr7:95030321 A/G cg21856205 chr7:94953877 PON1 -0.36 -5.71 -0.3 2.55e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs7939886 0.920 rs11227273 chr11:55893034 T/G cg03929089 chr4:120376271 NA 0.74 6.01 0.31 4.95e-9 Myopia (pathological); LUSC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg11764359 chr7:65958608 NA -0.7 -10.76 -0.51 2.16e-23 Aortic root size; LUSC cis rs2073300 0.609 rs17757442 chr20:23421101 A/G cg09953122 chr20:23471693 CST8 0.66 5.72 0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg06092702 chr1:163392909 NA 0.43 7.05 0.36 1.04e-11 Motion sickness; LUSC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg11871910 chr12:69753446 YEATS4 0.84 15.2 0.64 5.09e-40 Blood protein levels; LUSC cis rs6424115 0.830 rs1130321 chr1:24200524 C/T cg15997130 chr1:24165203 NA 0.52 8.62 0.43 2.75e-16 Immature fraction of reticulocytes; LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03934478 chr11:495069 RNH1 0.91 10.47 0.5 2.32e-22 Body mass index; LUSC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg24562669 chr7:97807699 LMTK2 0.34 5.95 0.31 6.83e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.34 5.68 0.3 2.99e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8114671 0.935 rs633198 chr20:33778434 T/C cg24642439 chr20:33292090 TP53INP2 -0.42 -6.14 -0.32 2.3e-9 Height; LUSC trans rs4689592 0.546 rs2359012 chr4:7066053 A/C cg07817883 chr1:32538562 TMEM39B -0.61 -7.36 -0.37 1.41e-12 Monocyte percentage of white cells; LUSC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg06112835 chr11:68658793 MRPL21 -0.51 -8.0 -0.4 2.02e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs9392918 0.967 rs6927500 chr6:7706004 A/G cg12631351 chr5:80256738 RASGRF2 -0.35 -5.99 -0.31 5.47e-9 Height; LUSC cis rs3849570 0.673 rs9877408 chr3:81974558 A/G cg07356753 chr3:81810745 GBE1 -0.5 -7.41 -0.38 1.04e-12 Waist circumference;Body mass index; LUSC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg06238570 chr21:40685208 BRWD1 -0.65 -10.69 -0.5 3.9e-23 Cognitive function; LUSC cis rs2898681 0.614 rs11947787 chr4:53705225 C/A cg00338735 chr4:53728038 RASL11B 0.42 5.77 0.3 1.86e-8 Optic nerve measurement (cup area); LUSC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg14829155 chr15:31115871 NA -0.58 -7.93 -0.4 3.26e-14 Huntington's disease progression; LUSC cis rs1045714 0.895 rs17833498 chr7:2647007 A/G cg24848437 chr7:2645542 IQCE -0.58 -6.95 -0.36 1.9e-11 Urate levels in lean individuals; LUSC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg22549504 chr19:17448937 GTPBP3 0.55 7.06 0.36 9.83e-12 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4660306 0.961 rs2152077 chr1:45986670 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.69 -0.34 9.17e-11 Homocysteine levels; LUSC cis rs10089 0.953 rs1432615 chr5:127395371 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 12.09 0.55 3.72e-28 Ileal carcinoids; LUSC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg01416388 chr22:39784598 NA -0.41 -6.14 -0.32 2.32e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6701037 1.000 rs1057305 chr1:175126223 T/A cg00321850 chr1:175162397 KIAA0040 -0.41 -6.96 -0.36 1.86e-11 Alcohol dependence; LUSC cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.67 -0.43 1.84e-16 Uric acid levels; LUSC cis rs34779708 0.966 rs4934730 chr10:35415555 A/G cg03585969 chr10:35415529 CREM 0.61 8.92 0.44 3.24e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg00857998 chr1:205179979 DSTYK 0.64 9.87 0.48 2.44e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7818345 0.967 rs12679671 chr8:19270831 G/T cg11303988 chr8:19266685 CSGALNACT1 0.36 7.01 0.36 1.34e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg04545296 chr12:48745243 ZNF641 0.37 6.68 0.34 1.01e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs11031096 0.589 rs935130 chr11:4213530 A/G cg18678763 chr11:4115507 RRM1 -0.41 -5.81 -0.3 1.43e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8014204 0.836 rs7150254 chr14:75299101 G/A cg06637938 chr14:75390232 RPS6KL1 0.65 11.0 0.52 3.23e-24 Caffeine consumption; LUSC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.5 7.43 0.38 9.25e-13 Personality dimensions; LUSC trans rs10221833 0.602 rs355889 chr2:165634651 C/T cg26993132 chr16:89239499 CDH15 0.31 5.99 0.31 5.47e-9 Response to statin therapy; LUSC cis rs7615952 0.733 rs13314847 chr3:125644788 C/T cg02807482 chr3:125708958 NA -0.48 -5.66 -0.3 3.18e-8 Blood pressure (smoking interaction); LUSC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg16680214 chr1:154839983 KCNN3 -0.51 -9.7 -0.47 9.21e-20 Prostate cancer; LUSC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg05084668 chr3:125655381 ALG1L -0.47 -6.65 -0.34 1.22e-10 Blood pressure (smoking interaction); LUSC trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg15704280 chr7:45808275 SEPT13 0.88 12.82 0.57 7.43e-31 Coronary artery disease; LUSC cis rs1577917 1.000 rs35797755 chr6:86706554 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.32 -0.41 2.25e-15 Response to antipsychotic treatment; LUSC cis rs6961069 0.806 rs11770907 chr7:80258630 G/A cg04458919 chr7:80252533 CD36 0.38 6.8 0.35 4.91e-11 Platelet count; LUSC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.8 9.39 0.46 9.42e-19 Mean platelet volume; LUSC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg03806693 chr22:41940476 POLR3H -0.93 -13.25 -0.59 1.69e-32 Vitiligo; LUSC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg16434002 chr17:42200994 HDAC5 0.45 6.17 0.32 1.94e-9 Total body bone mineral density; LUSC cis rs7618501 1.000 rs2271960 chr3:49878078 A/G cg12257692 chr3:49977190 RBM6 0.21 5.79 0.3 1.66e-8 Intelligence (multi-trait analysis); LUSC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg17749961 chr2:30669863 LCLAT1 1.19 11.85 0.54 2.81e-27 Midgestational circulating levels of PBDEs (fetal genetic effect); LUSC cis rs4664308 0.810 rs62175552 chr2:160937220 T/G cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs2898681 0.519 rs6848200 chr4:53730181 A/G cg00791764 chr4:53727839 RASL11B 0.56 7.7 0.39 1.6e-13 Optic nerve measurement (cup area); LUSC trans rs3808502 0.585 rs4549730 chr8:11239078 T/G cg08975724 chr8:8085496 FLJ10661 -0.4 -6.01 -0.31 4.99e-9 Neuroticism; LUSC cis rs7918232 0.556 rs788209 chr10:27434716 G/T cg14442939 chr10:27389572 ANKRD26 0.85 7.75 0.39 1.1e-13 Breast cancer; LUSC trans rs877282 0.842 rs7092986 chr10:756373 G/A cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs2243480 0.522 rs431168 chr7:65511604 G/T cg07424592 chr7:64974309 NA 1.12 6.76 0.35 6.14e-11 Diabetic kidney disease; LUSC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg26408565 chr15:76604113 ETFA -0.45 -7.02 -0.36 1.22e-11 Blood metabolite levels; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg24675658 chr1:53192096 ZYG11B 0.6 9.54 0.46 3e-19 Monocyte count; LUSC trans rs61931739 0.853 rs7137146 chr12:34102394 G/A cg13010199 chr12:38710504 ALG10B -0.46 -7.41 -0.38 1.01e-12 Morning vs. evening chronotype; LUSC cis rs9902453 0.689 rs56788338 chr17:28186557 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.15 0.52 9.34e-25 Coffee consumption (cups per day); LUSC cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg26528668 chr16:1614120 IFT140 0.4 6.43 0.33 4.5e-10 Coronary artery disease; LUSC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg22029157 chr1:209979665 IRF6 -0.64 -10.86 -0.51 9.52e-24 Orofacial clefts; LUSC trans rs6502050 0.799 rs6416859 chr17:80111442 G/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg22508957 chr16:3507546 NAT15 0.63 10.5 0.5 1.78e-22 Tuberculosis; LUSC cis rs3806843 0.576 rs246003 chr5:140340865 C/G cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg12386194 chr3:101231763 SENP7 0.63 8.55 0.42 4.4e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.909 rs28632018 chr4:120386730 T/C cg24375607 chr4:120327624 NA 0.78 11.54 0.53 3.88e-26 Corneal astigmatism; LUSC cis rs72781680 1.000 rs17763442 chr2:24255991 C/T cg08917208 chr2:24149416 ATAD2B 0.98 9.81 0.47 4.02e-20 Lymphocyte counts; LUSC cis rs11583043 0.957 rs6577223 chr1:101499750 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 6.11 0.32 2.76e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg08807101 chr21:30365312 RNF160 0.7 12.32 0.56 5.1e-29 Dental caries; LUSC trans rs3733585 0.673 rs9993410 chr4:9951264 C/T cg26043149 chr18:55253948 FECH -0.44 -6.77 -0.35 5.75e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs981844 0.740 rs6815202 chr4:154682440 A/G cg14289246 chr4:154710475 SFRP2 -0.52 -7.43 -0.38 9.09e-13 Response to statins (LDL cholesterol change); LUSC cis rs708547 0.599 rs1718864 chr4:57887471 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.64 0.39 2.25e-13 Response to bleomycin (chromatid breaks); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12738349 chr22:24236284 MIF -0.47 -6.31 -0.33 8.69e-10 Bipolar disorder and schizophrenia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04937561 chr11:57103057 SSRP1 0.41 6.57 0.34 1.96e-10 Asthma; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2901656 0.604 rs5029890 chr1:172451753 T/G cg03748243 chr1:172413542 C1orf105;PIGC 0.3 5.88 0.31 1.02e-8 Red cell distribution width;Platelet distribution width; LUSC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.16 0.45 5.55e-18 Hip circumference adjusted for BMI; LUSC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Vitiligo; LUSC cis rs9650657 0.665 rs1897207 chr8:10615235 C/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.77 -0.3 1.85e-8 Neuroticism; LUSC cis rs714027 0.967 rs193477 chr22:30451486 C/T cg11564601 chr22:30592435 NA -0.36 -6.71 -0.34 8.55e-11 Lymphocyte counts; LUSC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg21153622 chr11:89784906 NA -0.4 -6.15 -0.32 2.16e-9 HDL cholesterol; LUSC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg18876405 chr7:65276391 NA -0.55 -8.76 -0.43 9.78e-17 Aortic root size; LUSC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg07507251 chr3:52567010 NT5DC2 0.29 5.65 0.3 3.52e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg11102782 chr19:18549136 ISYNA1 -0.35 -6.71 -0.34 8.18e-11 Breast cancer; LUSC trans rs61931739 0.500 rs10844734 chr12:34043083 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.77 0.51 2.06e-23 Morning vs. evening chronotype; LUSC cis rs662064 0.962 rs683864 chr1:10561954 T/C cg20482658 chr1:10539492 PEX14 0.33 6.79 0.35 5.27e-11 Asthma; LUSC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg00579200 chr11:133705235 NA -0.39 -5.67 -0.3 3.03e-8 Childhood ear infection; LUSC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg12365402 chr11:9010492 NRIP3 0.46 8.41 0.42 1.18e-15 Hemoglobin concentration; LUSC cis rs6964587 1.000 rs411 chr7:91557758 C/G cg22709100 chr7:91322751 NA -0.4 -5.78 -0.3 1.67e-8 Breast cancer; LUSC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg00338735 chr4:53728038 RASL11B 0.49 5.67 0.3 3.11e-8 Optic nerve measurement (cup area); LUSC cis rs11098499 0.738 rs34965784 chr4:120361586 G/C cg09307838 chr4:120376055 NA 0.77 11.16 0.52 8.56e-25 Corneal astigmatism; LUSC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg10523679 chr1:76189770 ACADM 0.9 16.05 0.66 2.25e-43 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7829975 0.774 rs13259216 chr8:8673601 A/C cg15556689 chr8:8085844 FLJ10661 0.67 10.86 0.51 9.95e-24 Mood instability; LUSC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg07701084 chr6:150067640 NUP43 0.58 8.92 0.44 3.05e-17 Lung cancer; LUSC cis rs12956009 0.507 rs1560900 chr18:44866849 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.17 0.32 1.93e-9 Educational attainment (years of education); LUSC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg03289416 chr15:75166202 SCAMP2 0.44 6.93 0.35 2.24e-11 Breast cancer; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg08736216 chr1:53307985 ZYG11A -0.28 -5.74 -0.3 2.14e-8 Monocyte count; LUSC cis rs9300255 0.698 rs4759416 chr12:123746357 C/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.21 -0.32 1.59e-9 Neutrophil percentage of white cells; LUSC cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg00071950 chr4:10020882 SLC2A9 -0.52 -8.73 -0.43 1.21e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10911232 0.507 rs4642853 chr1:182996242 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.82e-24 Hypertriglyceridemia; LUSC cis rs61931739 0.534 rs1211286 chr12:34135581 T/C cg06521331 chr12:34319734 NA -0.49 -8.14 -0.41 8e-15 Morning vs. evening chronotype; LUSC cis rs1113500 0.836 rs2801220 chr1:108584649 A/G cg06207961 chr1:108661230 NA -0.37 -6.7 -0.34 9.07e-11 Growth-regulated protein alpha levels; LUSC cis rs3768617 0.565 rs10752898 chr1:183077896 A/G ch.1.3577855R chr1:183094577 LAMC1 0.73 11.27 0.52 3.57e-25 Fuchs's corneal dystrophy; LUSC cis rs11625487 0.957 rs7156032 chr14:77951364 G/A cg16049707 chr14:77965284 ISM2 -0.47 -6.2 -0.32 1.63e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs7843479 0.965 rs17581910 chr8:21799626 A/G cg17168535 chr8:21777572 XPO7 0.68 10.6 0.5 7.91e-23 Mean corpuscular volume; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg14238478 chr2:219433113 RQCD1;USP37 0.47 6.14 0.32 2.28e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg15147215 chr3:52552868 STAB1 -0.32 -6.34 -0.33 7.59e-10 Bipolar disorder; LUSC cis rs1044573 0.526 rs6050422 chr20:25177920 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.47 7.81 0.39 7.3e-14 Allergic rhinitis; LUSC trans rs12439619 0.693 rs28689861 chr15:82498710 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.44 -6.26 -0.32 1.19e-9 Intelligence (multi-trait analysis); LUSC cis rs12579753 0.789 rs1343933 chr12:82123301 A/C cg21231944 chr12:82153410 PPFIA2 -0.4 -6.07 -0.32 3.53e-9 Resting heart rate; LUSC trans rs7937682 0.889 rs1784786 chr11:111486043 A/G cg18187862 chr3:45730750 SACM1L -0.55 -7.31 -0.37 2.02e-12 Primary sclerosing cholangitis; LUSC cis rs9902453 0.904 rs4547389 chr17:28364768 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.53 -0.5 1.46e-22 Coffee consumption (cups per day); LUSC cis rs7568458 0.527 rs35416445 chr2:85773659 A/G cg17127132 chr2:85788382 GGCX 0.44 6.28 0.33 1.03e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7267979 0.816 rs405822 chr20:25501314 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.57 0.67 2.02e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7927592 0.913 rs7123564 chr11:68362164 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.8 -0.3 1.53e-8 Total body bone mineral density; LUSC cis rs4555082 0.789 rs2816649 chr14:105708326 A/G cg13114125 chr14:105738426 BRF1 -0.89 -15.51 -0.65 3e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs11864453 0.713 rs9925763 chr16:72142595 C/A cg23815491 chr16:72088622 HP 0.33 5.69 0.3 2.71e-8 Fibrinogen levels; LUSC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg13206674 chr6:150067644 NUP43 0.6 9.55 0.46 2.91e-19 Lung cancer; LUSC cis rs6964587 0.839 rs10236107 chr7:91485461 G/A cg17063962 chr7:91808500 NA -0.51 -7.8 -0.39 7.79e-14 Breast cancer; LUSC cis rs459571 0.916 rs467303 chr9:136904835 C/T cg13789015 chr9:136890014 NCRNA00094 0.73 13.4 0.59 4.45e-33 Platelet distribution width; LUSC cis rs11098499 0.954 rs3733523 chr4:120423719 C/T cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC trans rs11696501 0.688 rs6130897 chr20:44330004 C/T cg03272292 chr12:48577362 C12orf68 0.47 5.97 0.31 5.95e-9 Brain structure; LUSC cis rs12421382 0.659 rs979603 chr11:109384996 A/G cg11473876 chr11:109292803 C11orf87 -0.34 -5.69 -0.3 2.72e-8 Schizophrenia; LUSC cis rs2279817 1.000 rs10888048 chr1:18019742 C/T cg21791023 chr1:18019539 ARHGEF10L 0.49 7.02 0.36 1.22e-11 Neuroticism; LUSC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs240764 0.817 rs12201852 chr6:101149576 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.16 -0.32 2.04e-9 Neuroticism; LUSC cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg25643088 chr3:52874325 TMEM110 -0.4 -6.07 -0.32 3.44e-9 Schizophrenia; LUSC cis rs929596 0.614 rs10929302 chr2:234665782 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.7 -12.14 -0.55 2.42e-28 Total bilirubin levels in HIV-1 infection; LUSC cis rs870825 0.721 rs72703528 chr4:185607311 A/G cg04058563 chr4:185651563 MLF1IP 0.81 10.65 0.5 5.57e-23 Blood protein levels; LUSC cis rs2486288 0.656 rs7162022 chr15:45565253 C/T cg09092052 chr15:45571596 NA 0.48 6.61 0.34 1.56e-10 Glomerular filtration rate; LUSC cis rs3768617 0.510 rs20558 chr1:183094547 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg08917208 chr2:24149416 ATAD2B 0.51 5.76 0.3 1.88e-8 Lymphocyte counts; LUSC cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg03433033 chr1:76189801 ACADM -0.48 -7.12 -0.36 6.61e-12 Daytime sleep phenotypes; LUSC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg05283184 chr6:79620031 NA -0.58 -11.98 -0.55 9.46e-28 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg20203395 chr5:56204925 C5orf35 0.53 7.62 0.38 2.58e-13 Initial pursuit acceleration; LUSC cis rs9300255 0.664 rs7306755 chr12:123767929 G/A cg00376283 chr12:123451042 ABCB9 -0.72 -7.84 -0.39 5.96e-14 Neutrophil percentage of white cells; LUSC cis rs9814567 0.964 rs9833753 chr3:134213665 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.75 -0.6 2.1e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7168353 1.000 rs7168353 chr15:93638401 C/G cg12595281 chr15:93633172 RGMA 0.45 7.29 0.37 2.2e-12 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.54e-21 Electroencephalogram traits; LUSC cis rs7568458 0.905 rs17026396 chr2:85759127 C/T cg02493740 chr2:85810744 VAMP5 0.31 5.66 0.3 3.2e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11122272 0.701 rs2474628 chr1:231526000 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs936229 0.813 rs4886629 chr15:75072558 G/C cg10253484 chr15:75165896 SCAMP2 -0.5 -6.58 -0.34 1.84e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs12030196 0.788 rs10889125 chr1:59417116 A/G cg21156790 chr22:29168647 CCDC117 0.46 6.23 0.32 1.44e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs9916302 0.706 rs28482878 chr17:37497100 A/G cg07936489 chr17:37558343 FBXL20 0.82 9.99 0.48 9.51e-21 Glomerular filtration rate (creatinine); LUSC cis rs3772130 0.527 rs2141614 chr3:121590173 G/A cg20356878 chr3:121714668 ILDR1 0.61 9.9 0.48 2.05e-20 Cognitive performance; LUSC cis rs17685 0.712 rs1637049 chr7:75729975 C/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.22e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs12421382 0.659 rs1837397 chr11:109389803 A/C cg16359550 chr11:109292809 C11orf87 0.36 6.27 0.32 1.14e-9 Schizophrenia; LUSC cis rs4664308 0.618 rs55668231 chr2:160882066 A/G cg03641300 chr2:160917029 PLA2R1 -0.48 -7.73 -0.39 1.27e-13 Idiopathic membranous nephropathy; LUSC cis rs1865760 0.865 rs10946800 chr6:25957773 C/T cg16482183 chr6:26056742 HIST1H1C 0.47 6.93 0.35 2.2e-11 Height; LUSC cis rs7189233 0.531 rs8062535 chr16:53512488 G/A cg09728985 chr16:53543985 NA -0.33 -6.25 -0.32 1.23e-9 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.35e-22 Alzheimer's disease (late onset); LUSC cis rs2014572 0.967 rs11667407 chr19:57763122 C/T cg24459738 chr19:57751996 ZNF805 -0.51 -7.53 -0.38 4.85e-13 Hyperactive-impulsive symptoms; LUSC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg21856205 chr7:94953877 PON1 -0.36 -5.73 -0.3 2.29e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs11098499 0.575 rs907204 chr4:120238654 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.42e-10 Corneal astigmatism; LUSC cis rs4664308 0.870 rs2305818 chr2:161029218 G/A cg03641300 chr2:160917029 PLA2R1 -0.64 -10.9 -0.51 7.12e-24 Idiopathic membranous nephropathy; LUSC cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -11.65 -0.54 1.55e-26 Chronic sinus infection; LUSC cis rs2279817 0.691 rs7543007 chr1:17990475 A/G cg21791023 chr1:18019539 ARHGEF10L -0.46 -6.09 -0.32 3.1e-9 Neuroticism; LUSC cis rs1003719 0.715 rs2212742 chr21:38578685 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.16 -0.49 2.57e-21 Eye color traits; LUSC cis rs4843185 0.667 rs4143865 chr16:85716612 T/A cg00168118 chr16:85669675 KIAA0182 0.38 5.76 0.3 1.88e-8 Platelet distribution width; LUSC cis rs2230307 0.536 rs56215716 chr1:100447486 G/A cg24955406 chr1:100503596 HIAT1 0.56 6.08 0.32 3.31e-9 Carotid intima media thickness; LUSC trans rs6502050 0.835 rs8081783 chr17:80117388 G/A cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.46e-10 Life satisfaction; LUSC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.3 0.33 9.52e-10 Personality dimensions; LUSC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg03806693 chr22:41940476 POLR3H -0.93 -13.21 -0.59 2.52e-32 Vitiligo; LUSC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg11344533 chr11:111475393 SIK2 -0.49 -6.6 -0.34 1.59e-10 Primary sclerosing cholangitis; LUSC cis rs72949976 0.606 rs1922797 chr2:214027642 G/A cg08319019 chr2:214017104 IKZF2 0.68 11.42 0.53 9.95e-26 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs7809950 0.678 rs2395868 chr7:106897500 C/T cg23024343 chr7:107201750 COG5 0.61 9.59 0.46 2.11e-19 Coronary artery disease; LUSC cis rs7216064 0.906 rs8074644 chr17:65878217 G/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs1577917 0.655 rs9450311 chr6:86376586 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 5.68 0.3 2.98e-8 Response to antipsychotic treatment; LUSC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg13072238 chr3:49761600 GMPPB -0.65 -7.74 -0.39 1.17e-13 Menarche (age at onset); LUSC cis rs1577917 1.000 rs12204015 chr6:86598334 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.75 -0.43 1.05e-16 Response to antipsychotic treatment; LUSC cis rs7267979 1.000 rs2482937 chr20:25340786 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.83 -18.14 -0.7 1.17e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6847149 0.929 rs6847467 chr4:110800020 G/A cg07850274 chr4:110748770 RRH 0.5 7.18 0.37 4.51e-12 Exercise treadmill test traits; LUSC trans rs2562456 0.754 rs11673234 chr19:21507602 A/C cg00806126 chr19:22604979 ZNF98 -0.42 -5.99 -0.31 5.56e-9 Pain; LUSC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.9 0.35 2.69e-11 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg22907277 chr7:1156413 C7orf50 0.71 8.02 0.4 1.83e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg03804128 chr16:635623 NA 0.3 5.85 0.3 1.17e-8 Height; LUSC cis rs2969070 0.674 rs2906149 chr7:2524359 C/T cg03277898 chr7:2518824 NA 0.29 6.31 0.33 8.85e-10 Diastolic blood pressure; LUSC trans rs1015291 0.836 rs951062 chr12:19988377 C/T cg01501474 chr7:55323552 NA -0.45 -6.15 -0.32 2.27e-9 Diastolic blood pressure; LUSC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.58 -8.69 -0.43 1.65e-16 Menarche (age at onset); LUSC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg17911788 chr17:44343683 NA -0.32 -6.07 -0.32 3.55e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg12310025 chr6:25882481 NA -0.87 -16.55 -0.67 2.41e-45 Urate levels; LUSC cis rs9399401 0.921 rs9403387 chr6:142773210 G/T cg03128060 chr6:142623767 GPR126 0.31 5.74 0.3 2.09e-8 Chronic obstructive pulmonary disease; LUSC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg11941060 chr3:133502564 NA -0.61 -9.82 -0.47 3.8e-20 Iron status biomarkers; LUSC cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg05283184 chr6:79620031 NA -0.56 -11.88 -0.54 2.27e-27 Intelligence (multi-trait analysis); LUSC cis rs950027 0.595 rs2486288 chr15:45712339 T/C cg26924012 chr15:45694286 SPATA5L1 0.77 11.89 0.55 1.94e-27 Response to fenofibrate (adiponectin levels); LUSC cis rs9309473 0.607 rs1522926 chr2:73591241 T/C cg20560298 chr2:73613845 ALMS1 -0.5 -7.31 -0.37 1.93e-12 Metabolite levels; LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC cis rs9287719 0.967 rs7605461 chr2:10738134 G/A cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs1113500 0.565 rs1777455 chr1:108590288 C/A cg11967332 chr1:108735228 SLC25A24 -0.43 -5.91 -0.31 8.58e-9 Growth-regulated protein alpha levels; LUSC cis rs2742234 0.541 rs60845448 chr10:43721462 C/T cg02780029 chr10:43622663 RET 0.35 5.82 0.3 1.41e-8 Hirschsprung disease; LUSC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg11764359 chr7:65958608 NA -0.5 -6.25 -0.32 1.26e-9 Aortic root size; LUSC cis rs1322512 1.000 rs2800623 chr6:153003720 A/G cg03415253 chr6:152958462 SYNE1 0.39 5.72 0.3 2.4e-8 Tonometry; LUSC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg15445000 chr17:37608096 MED1 0.4 6.79 0.35 5.09e-11 Glomerular filtration rate (creatinine); LUSC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg10802521 chr3:52805072 NEK4 -0.53 -7.69 -0.39 1.62e-13 Bipolar disorder; LUSC cis rs4930561 0.714 rs7130844 chr11:67927517 C/T cg04465784 chr11:67976953 SUV420H1 -0.29 -5.81 -0.3 1.48e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg21724239 chr8:58056113 NA 0.78 8.56 0.42 4.04e-16 Developmental language disorder (linguistic errors); LUSC cis rs116988415 1.000 rs116988415 chr14:65292145 C/T cg00114569 chr14:65239327 SPTB 0.64 6.2 0.32 1.7e-9 Daytime sleep phenotypes; LUSC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg19920283 chr7:105172520 RINT1 0.57 6.08 0.32 3.34e-9 Bipolar disorder (body mass index interaction); LUSC cis rs16912285 0.688 rs12277966 chr11:24286633 G/A ch.11.24196551F chr11:24239977 NA 0.83 8.2 0.41 5.12e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg20503657 chr10:835505 NA 0.99 14.21 0.61 3.62e-36 Eosinophil percentage of granulocytes; LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg27535305 chr1:53392650 SCP2 0.38 7.08 0.36 8.63e-12 Monocyte count; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg15112475 chr7:1198522 ZFAND2A -0.38 -8.43 -0.42 1.02e-15 Longevity;Endometriosis; LUSC cis rs7336332 0.569 rs7988412 chr13:28000282 C/T cg22138327 chr13:27999177 GTF3A 0.8 10.52 0.5 1.55e-22 Weight; LUSC cis rs9303401 0.527 rs2116450 chr17:56745561 C/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.11 0.41 9.88e-15 Cognitive test performance; LUSC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC cis rs4423214 0.592 rs11233933 chr11:71210070 C/T cg05163923 chr11:71159392 DHCR7 -0.63 -6.62 -0.34 1.41e-10 Vitamin D levels; LUSC trans rs236907 0.859 rs35930163 chr1:171768184 G/A cg13482142 chr2:234261155 NA 0.5 6.19 0.32 1.8e-9 Mean platelet volume; LUSC cis rs6426558 0.537 rs2813969 chr1:227404082 T/C cg10327440 chr1:227177885 CDC42BPA 0.54 7.28 0.37 2.36e-12 Neutrophil percentage of white cells; LUSC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg06238570 chr21:40685208 BRWD1 -0.63 -10.68 -0.5 4.1000000000000003e-23 Cognitive function; LUSC cis rs73200209 0.744 rs10507269 chr12:116560327 A/T cg01776926 chr12:116560359 MED13L -0.51 -6.07 -0.32 3.48e-9 Total body bone mineral density; LUSC cis rs7809950 1.000 rs2253146 chr7:107200319 A/G cg23024343 chr7:107201750 COG5 -0.56 -8.76 -0.43 9.82e-17 Coronary artery disease; LUSC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg04518342 chr5:131593106 PDLIM4 0.45 8.31 0.41 2.47e-15 Breast cancer; LUSC cis rs4363385 0.818 rs57311099 chr1:153005597 A/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg15445000 chr17:37608096 MED1 0.38 6.61 0.34 1.53e-10 Glomerular filtration rate (creatinine); LUSC cis rs7814319 0.933 rs13261690 chr8:97238661 C/A cg20787634 chr8:97240163 UQCRB -0.35 -6.02 -0.31 4.5e-9 Lung function (FVC); LUSC cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.27 0.52 3.59e-25 Colorectal cancer; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs9287719 0.934 rs12692416 chr2:10745627 A/G cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg22117172 chr7:91764530 CYP51A1 0.33 5.85 0.3 1.18e-8 Breast cancer; LUSC trans rs1532331 0.864 rs6414900 chr5:43126528 G/A cg02477305 chr13:23993013 SACS 0.35 5.97 0.31 5.96e-9 Menarche (age at onset); LUSC cis rs2742417 1.000 rs2673037 chr3:45749094 A/T cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.47e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg17279839 chr7:150038598 RARRES2 0.41 6.29 0.33 9.69e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs500891 0.621 rs62419328 chr6:84158736 A/G cg08257003 chr6:84140564 ME1 0.37 9.12 0.45 7.43e-18 Platelet-derived growth factor BB levels; LUSC trans rs7824557 0.767 rs7003241 chr8:11169075 A/G cg06636001 chr8:8085503 FLJ10661 0.53 7.96 0.4 2.69e-14 Retinal vascular caliber; LUSC cis rs734999 0.545 rs28690427 chr1:2571823 A/G cg18854424 chr1:2615690 NA -0.5 -9.95 -0.48 1.35e-20 Ulcerative colitis; LUSC cis rs12594515 0.506 rs74199860 chr15:45989190 C/T cg01629716 chr15:45996671 NA 0.4 6.06 0.31 3.7e-9 Waist circumference;Weight; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg25767906 chr1:53392781 SCP2 0.53 9.87 0.48 2.59e-20 Monocyte count; LUSC cis rs2324229 0.828 rs1016242 chr6:83955571 A/T cg08257003 chr6:84140564 ME1 0.26 5.97 0.31 5.94e-9 Platelet-derived growth factor BB levels; LUSC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg08270630 chr22:50330655 NA -0.4 -6.28 -0.33 1.02e-9 Schizophrenia; LUSC cis rs887829 0.588 rs7556676 chr2:234658250 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.52 -8.83 -0.43 6.17e-17 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg05855489 chr10:104503620 C10orf26 0.58 7.81 0.39 7.28e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg08470875 chr2:26401718 FAM59B -0.67 -8.89 -0.44 3.83e-17 Gut microbiome composition (summer); LUSC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19346786 chr7:2764209 NA -0.37 -6.54 -0.34 2.33e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg24739457 chr1:205821442 NA 0.35 6.04 0.31 4.22e-9 Menarche (age at onset); LUSC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg11663144 chr21:46675770 NA -0.43 -7.39 -0.37 1.21e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg26384229 chr12:38710491 ALG10B 0.92 15.32 0.64 1.7e-40 Bladder cancer; LUSC cis rs3087591 0.708 rs2525563 chr17:29647908 T/G cg24425628 chr17:29625626 OMG;NF1 0.45 6.72 0.35 7.67e-11 Hip circumference; LUSC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg02038168 chr22:39784481 NA 0.46 7.61 0.38 2.88e-13 IgG glycosylation; LUSC cis rs72781680 0.898 rs72780188 chr2:24006065 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs75804782 0.521 rs1123472 chr2:239414355 C/T cg18131467 chr2:239335373 ASB1 0.61 6.25 0.32 1.22e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs9796 0.621 rs557864 chr15:41471358 T/C cg18705301 chr15:41695430 NDUFAF1 0.48 8.53 0.42 5.24e-16 Menopause (age at onset); LUSC cis rs9467711 0.606 rs68112369 chr6:26365759 T/C cg14345882 chr6:26364793 BTN3A2 0.61 5.65 0.3 3.4e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2236918 0.932 rs2526697 chr1:242040129 A/G cg17736920 chr1:242011382 EXO1 -0.41 -6.47 -0.33 3.48e-10 Menopause (age at onset); LUSC cis rs12310956 0.510 rs7965329 chr12:33868199 C/A cg06521331 chr12:34319734 NA -0.37 -6.07 -0.32 3.55e-9 Morning vs. evening chronotype; LUSC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.81 -0.35 4.64e-11 Total body bone mineral density; LUSC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg10018233 chr7:150070692 REPIN1 0.39 6.77 0.35 5.8e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs17092148 1.000 rs910872 chr20:33334540 T/C cg16810054 chr20:33298113 TP53INP2 -0.41 -6.42 -0.33 4.77e-10 Neuroticism; LUSC cis rs362272 0.524 rs2857982 chr4:3358665 G/A cg22655196 chr4:3374909 RGS12 0.3 5.78 0.3 1.71e-8 Serum sulfate level; LUSC cis rs600626 0.541 rs11236528 chr11:75469476 T/C cg24262691 chr11:75473276 NA 0.51 6.64 0.34 1.3100000000000001e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs4601821 0.895 rs2155464 chr11:113242448 T/C cg14159747 chr11:113255604 NA 0.26 6.03 0.31 4.42e-9 Alcoholic chronic pancreatitis; LUSC cis rs2481665 0.608 rs2476194 chr1:62594593 C/T cg18591186 chr1:62594603 INADL -0.61 -11.29 -0.53 2.88e-25 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6598955 0.543 rs61608823 chr1:26555090 G/A cg12744634 chr1:26560303 CCDC21 0.38 5.66 0.3 3.33e-8 Obesity-related traits; LUSC cis rs7208859 0.623 rs8079891 chr17:29058863 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs860295 0.702 rs11264387 chr1:155563152 G/T cg08949192 chr1:155289623 RUSC1;FDPS -0.34 -5.74 -0.3 2.13e-8 Body mass index; LUSC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg20701182 chr2:24300061 SF3B14 0.88 11.35 0.53 1.86e-25 Lymphocyte counts; LUSC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg20203395 chr5:56204925 C5orf35 -0.41 -6.15 -0.32 2.26e-9 Coronary artery disease; LUSC cis rs7903847 0.642 rs11189200 chr10:99156273 C/G cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg15242686 chr22:24348715 GSTTP1 0.43 6.38 0.33 5.87e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9467711 0.606 rs9393715 chr6:26375645 G/A cg09904177 chr6:26538194 HMGN4 -0.73 -6.89 -0.35 2.78e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs826838 0.616 rs7977357 chr12:38626008 C/G cg13010199 chr12:38710504 ALG10B -0.45 -6.75 -0.35 6.46e-11 Heart rate; LUSC cis rs7927592 0.956 rs55816191 chr11:68262979 G/T cg16797656 chr11:68205561 LRP5 0.35 5.84 0.3 1.23e-8 Total body bone mineral density; LUSC cis rs7584330 0.738 rs13398506 chr2:238374824 A/G cg16989719 chr2:238392110 NA -0.38 -6.6 -0.34 1.61e-10 Prostate cancer; LUSC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg02951883 chr7:2050386 MAD1L1 -0.45 -7.8 -0.39 7.97e-14 Bipolar disorder and schizophrenia; LUSC cis rs7223966 1.000 rs2854218 chr17:61942940 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.79 0.35 5.2e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg12292205 chr6:26970375 C6orf41 -0.58 -7.17 -0.37 4.88e-12 Intelligence (multi-trait analysis); LUSC cis rs2425143 1.000 rs6060572 chr20:34294015 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -6.4 -0.33 5.31e-10 Blood protein levels; LUSC cis rs950776 0.518 rs12591557 chr15:78811732 A/G cg22563815 chr15:78856949 CHRNA5 0.27 6.41 0.33 4.96e-10 Sudden cardiac arrest; LUSC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg18681998 chr4:17616180 MED28 0.86 15.62 0.65 1.1e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg11530693 chr1:120165357 ZNF697 0.69 10.79 0.51 1.79e-23 Systemic lupus erythematosus; LUSC trans rs57221529 0.766 rs72706606 chr5:558609 T/C cg08313168 chr12:7315531 NA 0.46 5.98 0.31 5.65e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg11645453 chr3:52864694 ITIH4 0.31 7.25 0.37 2.85e-12 Bipolar disorder; LUSC cis rs7267979 0.966 rs4813557 chr20:25292545 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -19.84 -0.74 2.04e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1215050 0.740 rs1214994 chr4:99035577 C/T cg05340658 chr4:99064831 C4orf37 0.46 7.34 0.37 1.66e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7772486 0.902 rs2748500 chr6:146314852 C/A cg05347473 chr6:146136440 FBXO30 0.43 7.16 0.36 5.17e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg08975724 chr8:8085496 FLJ10661 -0.49 -6.88 -0.35 2.88e-11 Triglycerides; LUSC cis rs4363385 0.510 rs11812015 chr1:153045584 G/T cg00922841 chr1:152955080 SPRR1A -0.38 -6.39 -0.33 5.43e-10 Inflammatory skin disease; LUSC trans rs4332037 0.754 rs62436669 chr7:1926636 G/A cg11693508 chr17:37793320 STARD3 0.67 7.77 0.39 9.74e-14 Bipolar disorder; LUSC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg03433033 chr1:76189801 ACADM 0.73 9.54 0.46 3.05e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs694739 0.628 rs645078 chr11:64135298 A/C cg23796481 chr11:64053134 BAD;GPR137 0.52 8.15 0.41 7.24e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs6076960 0.713 rs3865568 chr20:6249339 A/G cg21095983 chr6:86352623 SYNCRIP 0.51 7.68 0.39 1.8e-13 Smooth-surface caries; LUSC cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg21016266 chr12:122356598 WDR66 -0.57 -8.69 -0.43 1.64e-16 Mean corpuscular volume; LUSC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg15556689 chr8:8085844 FLJ10661 0.67 11.36 0.53 1.71e-25 Mood instability; LUSC cis rs2760061 0.626 rs596675 chr1:228117892 G/A cg18477163 chr1:228402036 OBSCN -0.56 -10.39 -0.49 4.2e-22 Diastolic blood pressure; LUSC trans rs6030 0.871 rs1894694 chr1:169515381 T/C cg16792071 chr10:134842795 NA 0.28 6.03 0.31 4.38e-9 Uric acid levels; LUSC trans rs11933661 0.528 rs1022008 chr4:130966269 C/G cg25019777 chr4:53525403 USP46 0.4 6.06 0.31 3.7e-9 Alcohol dependence; LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg11645453 chr3:52864694 ITIH4 0.38 8.65 0.43 2.25e-16 Bipolar disorder; LUSC cis rs1395 0.744 rs11126934 chr2:27476613 T/C cg23587288 chr2:27483067 SLC30A3 -0.29 -5.7 -0.3 2.61e-8 Blood metabolite levels; LUSC cis rs6424115 0.830 rs6663474 chr1:24199642 G/A cg15997130 chr1:24165203 NA 0.52 8.54 0.42 4.67e-16 Immature fraction of reticulocytes; LUSC cis rs1018836 0.884 rs7823461 chr8:91581075 T/C cg16814680 chr8:91681699 NA -0.75 -12.4 -0.56 2.68e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.2 0.66 5.64e-44 Platelet count; LUSC cis rs4947962 0.525 rs28374832 chr7:55148817 C/T cg23757825 chr7:55092271 EGFR -0.46 -5.78 -0.3 1.7e-8 Subjective response to lithium treatment; LUSC trans rs11098499 0.909 rs78332141 chr4:120375782 C/T cg25214090 chr10:38739885 LOC399744 0.57 8.27 0.41 3.3e-15 Corneal astigmatism; LUSC cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg18252515 chr7:66147081 NA -1.22 -14.19 -0.61 4.12e-36 Diabetic kidney disease; LUSC cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs11190604 1.000 rs11190578 chr10:102238953 C/T cg16342193 chr10:102329863 NA -0.35 -6.3 -0.33 9.17e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.53 -8.16 -0.41 6.97e-15 Lymphocyte counts; LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg11843238 chr5:131593191 PDLIM4 0.51 9.06 0.44 1.14e-17 Acylcarnitine levels; LUSC cis rs16910800 0.731 rs56768542 chr11:23191946 A/G cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs1434579 0.572 rs926052 chr19:44952236 A/T cg15540054 chr19:45004280 ZNF180 0.47 6.89 0.35 2.75e-11 Tuberculosis; LUSC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg21984481 chr17:79567631 NPLOC4 -0.67 -14.16 -0.61 5.79e-36 Eye color traits; LUSC cis rs765787 0.530 rs2554453 chr15:45522107 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.82 -0.43 6.55e-17 Uric acid levels; LUSC cis rs12986413 0.651 rs2238609 chr19:2146629 C/T cg09261902 chr19:2140048 AP3D1 0.34 6.07 0.32 3.48e-9 Height; LUSC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.39 -0.42 1.37e-15 Mood instability; LUSC trans rs933117 1.000 rs933117 chr21:31100797 C/T cg25856663 chr15:83317632 CPEB1 0.49 6.02 0.31 4.48e-9 Body mass index; LUSC cis rs7647973 0.710 rs6446285 chr3:49626306 G/A cg13072238 chr3:49761600 GMPPB -0.73 -8.34 -0.42 1.94e-15 Menarche (age at onset); LUSC cis rs793571 0.503 rs1427281 chr15:58959273 T/C cg05156742 chr15:59063176 FAM63B 0.5 6.68 0.34 9.81e-11 Schizophrenia; LUSC cis rs7072216 0.763 rs10736129 chr10:100171571 C/T cg26618903 chr10:100175079 PYROXD2 0.47 9.04 0.44 1.34e-17 Metabolite levels; LUSC cis rs9788682 0.948 rs905739 chr15:78845110 A/G cg24631222 chr15:78858424 CHRNA5 0.81 10.91 0.51 6.59e-24 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg25174290 chr11:3078921 CARS 0.41 6.39 0.33 5.64e-10 Longevity; LUSC cis rs4964805 1.000 rs11111792 chr12:104194857 C/G cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC trans rs61931739 0.620 rs708141 chr12:33719664 G/A cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg14895029 chr7:2775587 GNA12 -0.42 -6.25 -0.32 1.26e-9 Height; LUSC cis rs2760061 0.583 rs1774757 chr1:228211135 C/G cg04850211 chr1:228464232 OBSCN -0.37 -6.22 -0.32 1.49e-9 Diastolic blood pressure; LUSC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg26695010 chr11:65641043 EFEMP2 -0.48 -7.33 -0.37 1.75e-12 Eosinophil percentage of white cells; LUSC cis rs6500602 0.964 rs2896893 chr16:4478559 T/A cg08645402 chr16:4508243 NA 0.52 8.95 0.44 2.59e-17 Schizophrenia; LUSC cis rs950169 0.580 rs11630887 chr15:85193015 A/T cg11189052 chr15:85197271 WDR73 0.48 6.09 0.32 3.15e-9 Schizophrenia; LUSC cis rs926938 0.584 rs869990 chr1:115379614 A/G cg12756093 chr1:115239321 AMPD1 -0.54 -8.13 -0.41 8.4e-15 Autism; LUSC cis rs73198271 0.531 rs17154756 chr8:8652394 C/T cg01851573 chr8:8652454 MFHAS1 0.58 7.72 0.39 1.34e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs72777070 0.627 rs13418911 chr2:9795857 A/G cg14973360 chr2:9800511 NA -0.39 -5.84 -0.3 1.21e-8 Platelet-derived growth factor BB levels; LUSC cis rs12940923 1.000 rs12940923 chr17:56369849 A/T cg19466818 chr17:56409534 MIR142 -0.38 -6.76 -0.35 6.25e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs6964587 1.000 rs2269727 chr7:91752690 C/A cg17063962 chr7:91808500 NA 0.6 9.43 0.46 7.09e-19 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25401754 chr6:153304305 FBXO5 -0.41 -6.14 -0.32 2.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs11098499 0.913 rs68128210 chr4:120137819 T/G cg25214090 chr10:38739885 LOC399744 0.46 6.8 0.35 4.7e-11 Corneal astigmatism; LUSC cis rs7647973 1.000 rs56127630 chr3:49438036 C/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.46 -7.04 -0.36 1.09e-11 Menarche (age at onset); LUSC cis rs4319547 0.695 rs7969429 chr12:122875606 A/G cg23029597 chr12:123009494 RSRC2 -0.75 -9.47 -0.46 5.19e-19 Body mass index; LUSC cis rs1577917 1.000 rs1857965 chr6:86630776 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC cis rs12618769 0.597 rs72819986 chr2:99045867 G/C cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs11997175 0.574 rs4446694 chr8:33654978 A/G ch.8.33884649F chr8:33765107 NA 0.52 8.57 0.42 3.94e-16 Body mass index; LUSC cis rs478304 0.651 rs4014192 chr11:65498915 C/T cg10518572 chr11:65560635 OVOL1 -0.25 -5.75 -0.3 1.97e-8 Acne (severe); LUSC cis rs12136530 0.744 rs66932922 chr1:19776143 G/A cg01832549 chr1:19774989 CAPZB -0.33 -6.1 -0.32 2.92e-9 Lead levels in blood; LUSC cis rs5758659 0.714 rs7245 chr22:42481849 G/A cg04733989 chr22:42467013 NAGA -0.42 -6.91 -0.35 2.52e-11 Cognitive function; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg06263672 chr7:65235340 NA -0.46 -6.73 -0.35 7.28e-11 Calcium levels; LUSC cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg26384229 chr12:38710491 ALG10B 0.9 15.67 0.65 7.43e-42 Bladder cancer; LUSC cis rs2760061 0.583 rs708118 chr1:228201801 A/G cg01973587 chr1:228161476 NA 0.36 6.04 0.31 4.02e-9 Diastolic blood pressure; LUSC cis rs4332037 0.539 rs56016347 chr7:2060126 C/T cg23422044 chr7:1970798 MAD1L1 -0.57 -6.29 -0.33 1.02e-9 Bipolar disorder; LUSC cis rs1371867 0.846 rs1660348 chr8:101315248 A/G cg06636551 chr8:101224915 SPAG1 -0.4 -7.42 -0.38 9.55e-13 Atrioventricular conduction; LUSC cis rs17739794 0.517 rs35856917 chr8:774395 C/G cg07178994 chr8:816998 NA -0.39 -5.86 -0.31 1.11e-8 Clozapine-induced cytotoxicity; LUSC cis rs6500602 0.627 rs3848372 chr16:4587875 C/A cg08645402 chr16:4508243 NA 0.48 7.63 0.39 2.49e-13 Schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20256097 chr20:3185301 DDRGK1 0.75 6.06 0.31 3.66e-9 Cognitive performance; LUSC cis rs870825 0.616 rs28445002 chr4:185648977 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.76 -0.3 1.88e-8 Depression; LUSC cis rs7165170 0.808 rs12915979 chr15:91199025 C/T cg00756943 chr15:91208460 NA -0.39 -5.72 -0.3 2.38e-8 Crohn's disease;Inflammatory bowel disease; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg27218536 chr17:35969412 SYNRG 0.36 6.15 0.32 2.24e-9 Metabolite levels (Pyroglutamine); LUSC cis rs4664308 0.967 rs17831329 chr2:160915819 T/C cg03641300 chr2:160917029 PLA2R1 -0.69 -11.49 -0.53 5.49e-26 Idiopathic membranous nephropathy; LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg03665457 chr10:38645376 HSD17B7P2 -0.48 -6.83 -0.35 4.1e-11 Breast cancer; LUSC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg22029157 chr1:209979665 IRF6 0.73 8.97 0.44 2.23e-17 Cleft lip with or without cleft palate; LUSC cis rs9486719 0.947 rs6916232 chr6:96985959 A/T cg06623918 chr6:96969491 KIAA0776 0.81 10.09 0.48 4.42e-21 Migraine;Coronary artery disease; LUSC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.17 -0.32 1.98e-9 Total body bone mineral density; LUSC cis rs3768617 0.510 rs2333621 chr1:183090751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs708547 1.000 rs708547 chr4:57821309 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -5.76 -0.3 1.87e-8 Response to bleomycin (chromatid breaks); LUSC trans rs61931739 0.500 rs7977186 chr12:34431486 C/G cg26384229 chr12:38710491 ALG10B 0.91 15.7 0.65 5.65e-42 Morning vs. evening chronotype; LUSC cis rs6681460 0.866 rs996123 chr1:67025343 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.66 0.43 2.04e-16 Presence of antiphospholipid antibodies; LUSC cis rs9329221 0.868 rs7831557 chr8:10280228 C/T cg21775007 chr8:11205619 TDH -0.53 -7.17 -0.37 4.87e-12 Neuroticism; LUSC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg05234568 chr11:5960015 NA -0.57 -8.33 -0.41 2.06e-15 DNA methylation (variation); LUSC cis rs6942756 0.713 rs691807 chr7:129076203 G/C cg02491457 chr7:128862824 NA -0.43 -5.99 -0.31 5.36e-9 White matter hyperintensity burden; LUSC trans rs61931739 0.817 rs10772144 chr12:34242463 A/C cg13010199 chr12:38710504 ALG10B 0.4 6.21 0.32 1.55e-9 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11945604 chr12:6387873 NA -0.4 -5.94 -0.31 7.05e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs977987 0.806 rs11648176 chr16:75456423 C/G cg04384234 chr16:75411784 CFDP1 -0.43 -7.06 -0.36 9.49e-12 Dupuytren's disease; LUSC cis rs8099014 0.911 rs4383234 chr18:56126247 C/G cg12907477 chr18:56117327 MIR122 0.43 6.82 0.35 4.3e-11 Platelet count; LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg11218175 chr11:495084 RNH1 0.53 5.67 0.3 3.11e-8 Body mass index; LUSC cis rs7647973 0.593 rs58339610 chr3:49845006 T/A cg03060546 chr3:49711283 APEH -0.62 -7.22 -0.37 3.61e-12 Menarche (age at onset); LUSC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg22800045 chr5:56110881 MAP3K1 0.79 10.3 0.49 8.51e-22 Initial pursuit acceleration; LUSC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg08219700 chr8:58056026 NA 0.65 7.63 0.39 2.51e-13 Developmental language disorder (linguistic errors); LUSC trans rs6598955 0.671 rs11579354 chr1:26604071 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.53 -0.42 5.13e-16 Obesity-related traits; LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg16606324 chr3:10149918 C3orf24 0.68 9.9 0.48 2.05e-20 Alzheimer's disease; LUSC cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg24812749 chr6:127587940 RNF146 0.92 13.73 0.6 2.47e-34 Breast cancer; LUSC cis rs72781680 1.000 rs7578969 chr2:24168620 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs13064411 0.696 rs7619913 chr3:113017503 A/G cg18753928 chr3:113234510 CCDC52 -0.43 -6.19 -0.32 1.77e-9 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs4820539 1.000 rs4822360 chr22:23482460 A/G cg21100191 chr22:23484243 RTDR1 0.87 14.62 0.62 9.22e-38 Bone mineral density; LUSC cis rs4700695 0.640 rs27083 chr5:65435865 C/T cg21114390 chr5:65439923 SFRS12 -0.63 -8.93 -0.44 2.93e-17 Facial morphology (factor 19); LUSC cis rs3812762 0.833 rs10500705 chr11:8805261 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.36 -5.92 -0.31 8.14e-9 Hypospadias; LUSC cis rs7674212 0.541 rs11727498 chr4:104100987 C/T cg16532752 chr4:104119610 CENPE -0.48 -6.75 -0.35 6.72e-11 Type 2 diabetes; LUSC trans rs11700980 0.551 rs2832030 chr21:30114620 C/T cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs17407555 0.738 rs73212870 chr4:10111798 C/G cg00071950 chr4:10020882 SLC2A9 -0.52 -6.27 -0.32 1.15e-9 Schizophrenia (age at onset); LUSC cis rs9653442 0.564 rs4851253 chr2:100762786 T/G cg22139774 chr2:100720529 AFF3 -0.42 -7.01 -0.36 1.32e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6089584 0.830 rs6089309 chr20:60585687 T/C cg06108461 chr20:60628389 TAF4 -0.97 -16.57 -0.67 1.97e-45 Body mass index; LUSC cis rs9287719 0.967 rs12692417 chr2:10745718 C/G cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg05872129 chr22:39784769 NA -0.58 -9.85 -0.47 2.82e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11905131 chr22:24372483 LOC391322 0.53 8.83 0.44 5.84e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12210905 0.925 rs11961179 chr6:26994157 C/G cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.95 -0.31 6.94e-9 Hip circumference adjusted for BMI; LUSC cis rs9394152 0.817 rs4428487 chr6:33468394 G/A cg13560919 chr6:33536144 NA 0.6 10.56 0.5 1.11e-22 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9648716 0.515 rs801121 chr7:140745041 G/A cg23214464 chr7:140373596 ADCK2 -0.72 -6.12 -0.32 2.66e-9 Type 2 diabetes; LUSC cis rs1788820 0.843 rs1788821 chr18:21120869 A/G cg14672496 chr18:21087552 C18orf8 0.43 6.72 0.35 7.83e-11 Body mass index; LUSC cis rs55665837 0.559 rs9667144 chr11:14421101 C/T cg05501817 chr11:14380813 RRAS2 0.49 7.95 0.4 2.94e-14 Vitamin D levels; LUSC cis rs2439831 0.681 rs484846 chr15:43600803 T/C cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.93 0.66 6.95e-43 Lung cancer in ever smokers; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg07157834 chr1:205819609 PM20D1 0.99 21.51 0.76 5.21e-65 Menarche (age at onset); LUSC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.76 -0.39 1.05e-13 Height; LUSC cis rs568617 0.953 rs583887 chr11:65644027 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.49 -5.92 -0.31 8.15e-9 Crohn's disease; LUSC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.49 7.74 0.39 1.17e-13 Menarche (age at onset); LUSC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg02038168 chr22:39784481 NA -0.44 -6.68 -0.34 1.02e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg02951883 chr7:2050386 MAD1L1 -0.59 -10.72 -0.51 3.01e-23 Bipolar disorder and schizophrenia; LUSC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg06808227 chr14:105710500 BRF1 -0.66 -10.39 -0.49 4.39e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs1670533 1.000 rs12645644 chr4:1054159 C/T cg27284194 chr4:1044797 NA 0.48 6.88 0.35 2.99e-11 Recombination rate (females); LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg06600287 chr1:53387719 ECHDC2 -0.28 -5.74 -0.3 2.11e-8 Monocyte count; LUSC cis rs9287719 0.837 rs4233882 chr2:10755564 A/G cg00105475 chr2:10696890 NA 0.36 5.81 0.3 1.46e-8 Prostate cancer; LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11098499 0.954 rs1022145 chr4:120230979 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.11 0.32 2.8e-9 Corneal astigmatism; LUSC cis rs208520 0.690 rs10455595 chr6:66738034 T/C cg07460842 chr6:66804631 NA 1.1 17.23 0.69 4.59e-48 Exhaled nitric oxide output; LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.0 0.36 1.45e-11 Platelet count; LUSC cis rs60733400 0.667 rs4385650 chr1:2499898 G/A cg18854424 chr1:2615690 NA 0.47 9.26 0.45 2.46e-18 Multiple sclerosis; LUSC cis rs1863824 0.595 rs61859067 chr10:88159997 G/A cg07322936 chr10:88137208 NA -0.64 -9.01 -0.44 1.64e-17 Schizophrenia; LUSC cis rs11031096 0.711 rs10835719 chr11:4203906 A/G cg18678763 chr11:4115507 RRM1 0.39 5.7 0.3 2.57e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg24531977 chr5:56204891 C5orf35 0.56 8.35 0.42 1.8e-15 Coronary artery disease; LUSC cis rs4285028 0.948 rs12488334 chr3:121702526 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -9.06 -0.44 1.11e-17 Multiple sclerosis; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg27588902 chr6:42928151 GNMT -0.29 -6.49 -0.33 3.11e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg26354017 chr1:205819088 PM20D1 0.92 17.72 0.7 5.45e-50 Menarche (age at onset); LUSC cis rs57920188 0.535 rs4295855 chr1:4094993 C/T cg20703997 chr1:4087676 NA 0.59 8.18 0.41 6.18e-15 Interleukin-17 levels; LUSC cis rs11098499 0.779 rs80242894 chr4:120375752 G/A cg24375607 chr4:120327624 NA 0.78 11.59 0.54 2.37e-26 Corneal astigmatism; LUSC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.94 0.36 2.04e-11 Cystic fibrosis severity; LUSC cis rs453301 0.653 rs1562211 chr8:8902424 A/G cg08975724 chr8:8085496 FLJ10661 -0.45 -6.71 -0.34 8.13e-11 Joint mobility (Beighton score); LUSC cis rs728616 0.558 rs61859215 chr10:82151148 G/A cg05935833 chr10:81318306 SFTPA2 -0.44 -5.8 -0.3 1.57e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs79911532 0.515 rs75257637 chr7:75712848 C/T cg03592824 chr7:75666768 STYXL1 0.67 6.41 0.33 4.98e-10 Mononucleosis; LUSC cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg06092702 chr1:163392909 NA -0.45 -7.37 -0.37 1.39e-12 Motion sickness; LUSC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg08645402 chr16:4508243 NA -0.45 -7.09 -0.36 8e-12 Schizophrenia; LUSC cis rs9467773 0.620 rs2498351 chr6:26659642 C/T cg09904177 chr6:26538194 HMGN4 0.66 11.7 0.54 1.01e-26 Intelligence (multi-trait analysis); LUSC cis rs2668423 0.502 rs2074898 chr19:1391361 A/G cg02639931 chr19:1387894 NDUFS7 -0.69 -14.98 -0.63 3.71e-39 Nonalcoholic fatty liver disease; LUSC cis rs7089973 0.966 rs61867966 chr10:116584362 T/C cg23260525 chr10:116636907 FAM160B1 0.37 7.06 0.36 9.48e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg19468946 chr17:37922297 IKZF3 -0.43 -6.79 -0.35 5.22e-11 Self-reported allergy; LUSC cis rs9326248 0.539 rs660443 chr11:116760693 T/C cg26566898 chr11:117069891 TAGLN 0.37 7.02 0.36 1.28e-11 Blood protein levels; LUSC cis rs7903847 0.642 rs7896100 chr10:99156994 C/T cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs929354 0.772 rs4716460 chr7:156970054 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg15934090 chr1:100435551 SLC35A3 -0.43 -7.44 -0.38 8.6e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs754466 0.580 rs11002294 chr10:79540588 T/C cg17075019 chr10:79541650 NA -0.78 -12.36 -0.56 3.58e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs611744 0.647 rs12675265 chr8:109268805 C/T cg18478394 chr8:109455254 TTC35 0.42 6.57 0.34 1.93e-10 Dupuytren's disease; LUSC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg09074113 chr2:20870087 GDF7 -0.38 -7.85 -0.39 5.75e-14 Abdominal aortic aneurysm; LUSC cis rs921665 0.748 rs1869420 chr2:3202073 C/T cg16434511 chr2:3151078 NA -0.58 -5.93 -0.31 7.76e-9 World class endurance athleticism; LUSC cis rs9329289 0.610 rs10903783 chr10:2540623 C/T cg15501526 chr10:2543763 NA 0.55 10.24 0.49 1.44e-21 Age-related hearing impairment; LUSC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg03609598 chr5:56110824 MAP3K1 -0.41 -5.84 -0.3 1.25e-8 Initial pursuit acceleration; LUSC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg17911788 chr17:44343683 NA -0.44 -8.01 -0.4 1.9e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs965604 1.000 rs8042238 chr15:78774271 C/T cg18825076 chr15:78729989 IREB2 -0.43 -6.88 -0.35 3.03e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg06212747 chr3:49208901 KLHDC8B 0.44 6.04 0.31 4.11e-9 Parkinson's disease; LUSC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -7.21 -0.37 3.77e-12 Monocyte percentage of white cells; LUSC cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg20302533 chr7:39170763 POU6F2 0.51 7.94 0.4 3.05e-14 IgG glycosylation; LUSC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.92 -0.81 3.6e-78 Height; LUSC cis rs4400599 0.618 rs2220390 chr1:154233016 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.08 -0.32 3.36e-9 Platelet distribution width; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg22963979 chr7:1858916 MAD1L1 -0.55 -8.17 -0.41 6.24e-15 Bipolar disorder and schizophrenia; LUSC trans rs61931739 0.500 rs11053243 chr12:34514155 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.09 0.45 9.21e-18 Morning vs. evening chronotype; LUSC cis rs8060686 0.641 rs73612690 chr16:68153200 G/A cg05110241 chr16:68378359 PRMT7 -0.52 -6.21 -0.32 1.6e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9462027 0.606 rs2815001 chr6:34634353 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.24e-9 Systemic lupus erythematosus; LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.43 0.38 9.46e-13 Bipolar disorder; LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg14668632 chr7:2872130 GNA12 0.46 6.88 0.35 2.99e-11 Height; LUSC trans rs7939886 0.920 rs1031978 chr11:55965641 G/T cg03929089 chr4:120376271 NA 0.81 6.11 0.32 2.73e-9 Myopia (pathological); LUSC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg18512352 chr11:47633146 NA -0.46 -9.21 -0.45 3.73e-18 Subjective well-being; LUSC cis rs6484504 0.600 rs1323738 chr11:31344898 T/C cg06552810 chr11:31128660 NA 0.39 6.77 0.35 5.8e-11 Red blood cell count; LUSC trans rs11039798 0.588 rs59777067 chr11:49015350 C/T cg15704280 chr7:45808275 SEPT13 0.77 8.54 0.42 4.87e-16 Axial length; LUSC cis rs372883 0.530 rs2832305 chr21:30752964 G/A cg08807101 chr21:30365312 RNF160 0.65 10.11 0.48 3.86e-21 Pancreatic cancer; LUSC cis rs1801251 1.000 rs12990821 chr2:233617585 C/G cg25237894 chr2:233734115 C2orf82 0.35 6.55 0.34 2.23e-10 Coronary artery disease; LUSC cis rs4909189 1.000 rs62493650 chr7:158135570 G/T cg06219351 chr7:158114137 PTPRN2 -0.53 -8.41 -0.42 1.21e-15 Response to amphetamines; LUSC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.25 -0.32 1.23e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs68092024 0.731 rs793479 chr3:99488232 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -6.14 -0.32 2.31e-9 Cleft lip with or without cleft palate; LUSC cis rs2274273 0.662 rs66476033 chr14:55660863 C/A cg04306507 chr14:55594613 LGALS3 0.48 9.67 0.47 1.2e-19 Protein biomarker; LUSC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg16049864 chr8:95962084 TP53INP1 -0.56 -10.15 -0.49 2.93e-21 Type 2 diabetes; LUSC cis rs17155006 0.783 rs410286 chr7:107749257 A/T cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.65 -0.71 1.04e-53 Height; LUSC cis rs11997175 0.545 rs66783231 chr8:33811467 A/T ch.8.33884649F chr8:33765107 NA 0.47 6.93 0.35 2.12e-11 Body mass index; LUSC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs7246967 0.673 rs12978794 chr19:22812134 C/T cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg08798685 chr6:27730294 NA -0.63 -5.93 -0.31 7.45e-9 Depression; LUSC cis rs7914558 1.000 rs11191577 chr10:104902165 A/G cg05855489 chr10:104503620 C10orf26 0.6 9.68 0.47 1.11e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg25427524 chr10:38739819 LOC399744 -0.69 -12.68 -0.57 2.3e-30 Extrinsic epigenetic age acceleration; LUSC trans rs11992162 0.636 rs4841642 chr8:11798334 C/T cg15556689 chr8:8085844 FLJ10661 0.48 6.77 0.35 5.73e-11 Monocyte count; LUSC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg21770322 chr7:97807741 LMTK2 0.4 7.0 0.36 1.44e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs734999 0.545 rs4474198 chr1:2553758 C/T cg18854424 chr1:2615690 NA 0.51 10.5 0.5 1.82e-22 Ulcerative colitis; LUSC cis rs6696846 0.715 rs61822659 chr1:205142847 G/A cg21643547 chr1:205240462 TMCC2 -0.44 -7.93 -0.4 3.35e-14 Red blood cell count; LUSC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg24642844 chr7:1081250 C7orf50 -0.69 -9.81 -0.47 3.94e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 12.92 0.58 3.05e-31 Platelet count; LUSC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.75 0.39 1.11e-13 Bipolar disorder; LUSC cis rs9905704 0.671 rs28709536 chr17:57008912 C/A cg05425664 chr17:57184151 TRIM37 -0.49 -7.35 -0.37 1.51e-12 Testicular germ cell tumor; LUSC cis rs703842 0.575 rs701006 chr12:58106836 C/T cg12615879 chr12:58013172 SLC26A10 -0.26 -5.8 -0.3 1.54e-8 Multiple sclerosis; LUSC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg20891558 chr2:74357851 NA 0.79 14.5 0.62 2.72e-37 Gestational age at birth (maternal effect); LUSC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg27529037 chr20:44575021 PCIF1 0.4 6.99 0.36 1.49e-11 Intelligence (multi-trait analysis); LUSC cis rs6840360 1.000 rs4696111 chr4:152671405 T/C cg22705602 chr4:152727874 NA -0.27 -5.92 -0.31 8.09e-9 Intelligence (multi-trait analysis); LUSC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg10792982 chr14:105748885 BRF1 0.52 9.43 0.46 7.25e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs28655083 0.957 rs2171096 chr16:77079043 T/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.44 -6.83 -0.35 3.99e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs116095464 0.558 rs9312956 chr5:201812 T/C cg22496380 chr5:211416 CCDC127 -0.87 -8.95 -0.44 2.56e-17 Breast cancer; LUSC cis rs4654899 0.758 rs6690574 chr1:21504279 G/A cg01072550 chr1:21505969 NA -0.54 -8.22 -0.41 4.67e-15 Superior frontal gyrus grey matter volume; LUSC cis rs225245 0.755 rs226441 chr17:34033072 C/T cg05299278 chr17:33885742 SLFN14 0.3 6.67 0.34 1.08e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs941408 0.515 rs759067 chr19:2775668 C/T cg06609049 chr19:2785107 THOP1 1.15 22.39 0.77 1.92e-68 Total cholesterol levels; LUSC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -6.9 -0.35 2.59e-11 Alzheimer's disease (late onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02356872 chr19:49617495 LIN7B -0.48 -6.6 -0.34 1.6e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21897817 chr19:50432804 NUP62;IL4I1;ATF5 -0.4 -6.12 -0.32 2.6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7582180 0.614 rs4149518 chr2:101013649 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.68 -0.43 1.83e-16 Intelligence (multi-trait analysis); LUSC cis rs7674212 0.541 rs2623064 chr4:104030792 C/A cg16532752 chr4:104119610 CENPE -0.49 -6.82 -0.35 4.2e-11 Type 2 diabetes; LUSC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg05855489 chr10:104503620 C10orf26 0.6 9.56 0.46 2.74e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs61990749 0.544 rs8003979 chr14:78211290 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.62 6.59 0.34 1.76e-10 Fibroblast growth factor basic levels; LUSC cis rs55665837 0.539 rs10500804 chr11:14910273 A/C cg19336497 chr11:14380999 RRAS2 -0.38 -6.91 -0.35 2.47e-11 Vitamin D levels; LUSC trans rs2197308 0.765 rs11182481 chr12:37926019 T/C cg06521331 chr12:34319734 NA -0.41 -6.27 -0.32 1.09e-9 Morning vs. evening chronotype; LUSC cis rs939658 0.805 rs35602654 chr15:79417527 T/A cg17916960 chr15:79447300 NA -0.52 -10.31 -0.49 8.12e-22 Refractive error; LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.38 0.42 1.53e-15 Bipolar disorder; LUSC cis rs9660992 0.662 rs12092492 chr1:205251880 T/C cg21545522 chr1:205238299 TMCC2 0.48 8.99 0.44 1.83e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1215050 0.791 rs700738 chr4:98907909 C/A cg05340658 chr4:99064831 C4orf37 -0.41 -6.48 -0.33 3.32e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.49 -0.42 6.81e-16 Platelet count; LUSC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg07424592 chr7:64974309 NA 0.69 6.19 0.32 1.81e-9 Diabetic kidney disease; LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg05368731 chr17:41323189 NBR1 0.93 15.94 0.66 6.18e-43 Menopause (age at onset); LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg21782813 chr7:2030301 MAD1L1 0.37 6.27 0.32 1.13e-9 Bipolar disorder and schizophrenia; LUSC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg00750074 chr16:89608354 SPG7 -0.45 -7.75 -0.39 1.11e-13 Multiple myeloma (IgH translocation); LUSC cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg08999081 chr20:33150536 PIGU -0.53 -10.58 -0.5 9.77e-23 Glomerular filtration rate (creatinine); LUSC cis rs2070433 0.800 rs11702190 chr21:47877367 C/T cg12379764 chr21:47803548 PCNT 0.78 9.92 0.48 1.67e-20 Lymphocyte counts; LUSC cis rs6696846 0.905 rs12117194 chr1:205040943 C/G cg21643547 chr1:205240462 TMCC2 0.36 6.84 0.35 3.88e-11 Red blood cell count; LUSC cis rs7223966 1.000 rs8069687 chr17:61883023 C/T cg00945038 chr17:61921165 SMARCD2 -0.38 -5.85 -0.3 1.18e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg09021430 chr5:549028 NA -0.55 -7.09 -0.36 7.87e-12 Lung disease severity in cystic fibrosis; LUSC cis rs11031096 0.711 rs11031156 chr11:4179021 C/T cg18678763 chr11:4115507 RRM1 -0.4 -5.64 -0.3 3.54e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.33 0.53 2.12e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg21033440 chr11:65409861 SIPA1 -0.55 -7.54 -0.38 4.47e-13 Blood pressure (age interaction); LUSC cis rs4780401 0.609 rs11639945 chr16:11824056 T/G cg01061890 chr16:11836724 TXNDC11 -0.56 -8.33 -0.41 2.19e-15 Rheumatoid arthritis; LUSC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs8060686 0.516 rs7187202 chr16:68273895 T/C cg09835421 chr16:68378352 PRMT7 -0.51 -6.28 -0.32 1.06e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg05552183 chr6:42928497 GNMT 0.48 8.2 0.41 5.1e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9788721 0.902 rs951266 chr15:78878541 C/T cg06917634 chr15:78832804 PSMA4 -0.42 -5.88 -0.31 1.02e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg11366901 chr6:160182831 ACAT2 0.97 13.2 0.59 2.63e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs11098499 0.644 rs10050092 chr4:120532085 T/C cg24375607 chr4:120327624 NA 0.7 11.42 0.53 1.04e-25 Corneal astigmatism; LUSC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg20476274 chr7:133979776 SLC35B4 0.87 16.91 0.68 8.63e-47 Mean platelet volume; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.96 0.77 8.44e-67 Prudent dietary pattern; LUSC trans rs7824557 0.767 rs11250127 chr8:11170209 G/A cg06636001 chr8:8085503 FLJ10661 0.53 7.9 0.4 3.97e-14 Retinal vascular caliber; LUSC cis rs12940923 1.000 rs11867412 chr17:56382512 C/T cg19466818 chr17:56409534 MIR142 -0.38 -6.57 -0.34 1.92e-10 Circulating myeloperoxidase levels (plasma); LUSC cis rs7264396 0.528 rs6058370 chr20:34518592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -6.64 -0.34 1.27e-10 Total cholesterol levels; LUSC cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg12011299 chr4:100065546 ADH4 -0.71 -11.17 -0.52 7.69e-25 Alcohol dependence; LUSC cis rs7927771 0.524 rs6485763 chr11:47627302 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.89e-10 Subjective well-being; LUSC cis rs8044995 0.563 rs8058517 chr16:68379860 A/G cg09835421 chr16:68378352 PRMT7 0.75 8.49 0.42 7.01e-16 Schizophrenia; LUSC cis rs763121 0.853 rs5750621 chr22:38956166 C/T cg14440974 chr22:39074834 NA -0.38 -6.31 -0.33 8.64e-10 Menopause (age at onset); LUSC cis rs61931739 0.534 rs12372557 chr12:34363843 C/T cg06521331 chr12:34319734 NA -0.42 -6.56 -0.34 2.01e-10 Morning vs. evening chronotype; LUSC cis rs25645 0.502 rs7207600 chr17:38091660 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.53 -8.5 -0.42 6.25e-16 Myeloid white cell count; LUSC cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.73 -12.8 -0.57 8.73e-31 Personality dimensions; LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg05665937 chr4:1216051 CTBP1 0.43 6.86 0.35 3.35e-11 Obesity-related traits; LUSC cis rs7267979 0.932 rs1985737 chr20:25591468 T/A cg24626310 chr20:25276739 ABHD12;PYGB 0.85 18.47 0.71 5.57e-53 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg22920501 chr2:26401640 FAM59B 0.82 12.42 0.56 2.16e-29 Gut microbiome composition (summer); LUSC cis rs7312933 0.618 rs6582390 chr12:42634586 C/T cg17420585 chr12:42539391 GXYLT1 -0.34 -6.5 -0.33 3e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg18512352 chr11:47633146 NA -0.46 -9.22 -0.45 3.55e-18 Subjective well-being; LUSC cis rs7043114 0.507 rs10992340 chr9:95209693 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.36 -0.33 6.67e-10 Height; LUSC cis rs9311676 0.632 rs11130631 chr3:58366128 G/C cg13750441 chr3:58318267 PXK 0.35 6.76 0.35 6.33e-11 Systemic lupus erythematosus; LUSC trans rs9944715 0.954 rs12962307 chr18:43815420 A/T cg01718231 chr17:29326311 RNF135 -0.5 -7.07 -0.36 9.28e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs34779708 0.966 rs4934734 chr10:35434373 T/C cg04310649 chr10:35416472 CREM -0.43 -6.64 -0.34 1.27e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg09877947 chr5:131593287 PDLIM4 -0.46 -7.01 -0.36 1.33e-11 Blood metabolite levels; LUSC cis rs9323205 0.731 rs56024569 chr14:51697655 A/G cg23942311 chr14:51606299 NA -0.45 -8.52 -0.42 5.51e-16 Cancer; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.36 -0.37 1.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs12681287 0.640 rs13252046 chr8:87477751 G/T cg27223183 chr8:87520930 FAM82B -0.53 -7.16 -0.36 5.04e-12 Caudate activity during reward; LUSC trans rs2048656 0.523 rs1976673 chr8:9679780 T/A cg15556689 chr8:8085844 FLJ10661 0.48 6.73 0.35 7.29e-11 Schizophrenia; LUSC cis rs12908161 0.960 rs11633450 chr15:85307287 C/T cg17173187 chr15:85201210 NMB 0.44 8.08 0.4 1.23e-14 Schizophrenia; LUSC cis rs7584330 0.554 rs77180399 chr2:238442951 G/A cg14458575 chr2:238380390 NA 0.59 6.95 0.36 1.94e-11 Prostate cancer; LUSC cis rs2797160 1.000 rs9491471 chr6:125991715 C/T cg05901451 chr6:126070800 HEY2 -0.5 -7.88 -0.4 4.65e-14 Endometrial cancer; LUSC cis rs6582630 0.638 rs12425531 chr12:38550387 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.41 -0.33 5.01e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7681440 0.904 rs1442153 chr4:90775719 T/G cg01966878 chr4:90757139 SNCA -0.34 -5.85 -0.31 1.15e-8 Dementia with Lewy bodies; LUSC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 6.07 0.32 3.48e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9925964 0.804 rs9926533 chr16:31014179 C/T cg02466173 chr16:30829666 NA 0.32 5.8 0.3 1.55e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1712517 0.771 rs2008530 chr10:105058839 G/A cg05636881 chr10:105038444 INA 0.38 6.21 0.32 1.61e-9 Migraine; LUSC cis rs28830936 0.966 rs28680296 chr15:42121538 C/G cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.85 -0.31 1.15e-8 Diastolic blood pressure; LUSC cis rs7605378 1.000 rs769957 chr2:200695524 A/C cg23649088 chr2:200775458 C2orf69 0.52 8.12 0.41 9.23e-15 Osteoporosis; LUSC cis rs2290159 0.747 rs6777175 chr3:12646255 A/T cg23032965 chr3:12705835 RAF1 0.71 8.68 0.43 1.75e-16 Cholesterol, total; LUSC trans rs61931739 0.782 rs7969373 chr12:34249655 T/G cg24313572 chr1:56050060 NA -0.31 -6.38 -0.33 5.9e-10 Morning vs. evening chronotype; LUSC cis rs72781680 1.000 rs12620594 chr2:24194490 G/A cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs4595586 0.545 rs6580892 chr12:39370237 G/C cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg18252515 chr7:66147081 NA -1.21 -13.94 -0.61 4.07e-35 Diabetic kidney disease; LUSC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.83 0.44 5.91e-17 Schizophrenia; LUSC cis rs1371867 0.846 rs1788196 chr8:101290088 C/T cg06636551 chr8:101224915 SPAG1 -0.4 -7.41 -0.38 1.06e-12 Atrioventricular conduction; LUSC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg11247378 chr22:39784982 NA -0.62 -11.22 -0.52 5.2e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs1729951 0.546 rs12054218 chr3:136677496 C/G cg21827317 chr3:136751795 NA 0.39 6.91 0.35 2.41e-11 Neuroticism; LUSC cis rs7712401 0.686 rs154511 chr5:122195554 T/A cg19077854 chr5:122220652 SNX24 0.32 7.19 0.37 4.32e-12 Mean platelet volume; LUSC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.55 -0.38 4.17e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7937682 0.889 rs12360825 chr11:111528786 A/T cg18187862 chr3:45730750 SACM1L 0.55 7.05 0.36 1.02e-11 Primary sclerosing cholangitis; LUSC cis rs2624839 0.704 rs2624838 chr3:50205642 C/G cg24110177 chr3:50126178 RBM5 -0.41 -6.08 -0.32 3.23e-9 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00552226 chr2:70475288 TIA1 0.4 5.96 0.31 6.58e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs896854 0.573 rs13271375 chr8:95853907 A/G cg09323728 chr8:95962352 TP53INP1 -0.41 -8.57 -0.42 4e-16 Type 2 diabetes; LUSC cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg19784903 chr17:45786737 TBKBP1 -0.46 -6.79 -0.35 5.19e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.98 0.36 1.57e-11 Lung cancer in ever smokers; LUSC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg20203395 chr5:56204925 C5orf35 0.41 6.11 0.32 2.81e-9 Coronary artery disease; LUSC cis rs6845621 0.901 rs1452553 chr4:18920030 C/G cg12196642 chr4:18937545 NA -0.33 -6.46 -0.33 3.69e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2439831 0.541 rs12440854 chr15:43610672 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.17 14.79 0.63 1.99e-38 Lung cancer in ever smokers; LUSC cis rs9527 0.614 rs11191589 chr10:104930382 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.53 0.46 3.35e-19 Arsenic metabolism; LUSC cis rs11864453 0.826 rs12708928 chr16:72137227 C/A cg23815491 chr16:72088622 HP 0.34 5.93 0.31 7.76e-9 Fibrinogen levels; LUSC cis rs80130819 0.515 rs1793917 chr12:48384944 A/T cg24011408 chr12:48396354 COL2A1 0.51 6.38 0.33 5.94e-10 Prostate cancer; LUSC cis rs11532322 1 rs11532322 chr12:123731423 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.36 -0.33 6.49e-10 Schizophrenia; LUSC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg08677398 chr8:58056175 NA 0.53 6.36 0.33 6.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg00166722 chr3:10149974 C3orf24 0.6 8.39 0.42 1.4e-15 Alzheimer's disease; LUSC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg21724239 chr8:58056113 NA -0.54 -5.72 -0.3 2.31e-8 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.45 0.53 7.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6977660 0.652 rs10486362 chr7:19755224 A/G cg05791153 chr7:19748676 TWISTNB -1.1 -11.46 -0.53 7.04e-26 Thyroid stimulating hormone; LUSC cis rs4808199 1.000 rs12972397 chr19:19562349 G/A cg03709012 chr19:19516395 GATAD2A 1.1 14.47 0.62 3.47e-37 Nonalcoholic fatty liver disease; LUSC trans rs11250097 0.549 rs11784897 chr8:11310442 G/A cg15556689 chr8:8085844 FLJ10661 -0.59 -8.22 -0.41 4.66e-15 Neuroticism; LUSC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg07636037 chr3:49044803 WDR6 0.69 8.71 0.43 1.39e-16 Menarche (age at onset); LUSC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs17401966 0.898 rs12757288 chr1:10323921 T/C cg19773385 chr1:10388646 KIF1B -0.5 -8.74 -0.43 1.19e-16 Hepatocellular carcinoma; LUSC trans rs1941687 0.797 rs6507069 chr18:31393188 C/G cg27147174 chr7:100797783 AP1S1 -0.44 -6.45 -0.33 3.83e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs11122272 0.735 rs2437148 chr1:231513979 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22269486 chr8:27630099 CCDC25 -0.42 -6.25 -0.32 1.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9660992 1.000 rs9660992 chr1:205249450 A/G cg00857998 chr1:205179979 DSTYK 0.44 6.6 0.34 1.61e-10 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9467773 0.620 rs2504599 chr6:26641060 C/T cg09904177 chr6:26538194 HMGN4 0.66 11.72 0.54 8.26e-27 Intelligence (multi-trait analysis); LUSC cis rs1595825 0.891 rs73056859 chr2:198801720 A/G cg00982548 chr2:198649783 BOLL -0.56 -7.01 -0.36 1.36e-11 Ulcerative colitis; LUSC cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs6835098 1.000 rs6826412 chr4:174109622 C/T cg08422745 chr4:174089978 GALNT7 -0.8 -12.96 -0.58 2.11e-31 Dementia and core Alzheimer's disease neuropathologic changes; LUSC trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg03929089 chr4:120376271 NA 0.54 6.59 0.34 1.68e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg13736514 chr6:26305472 NA -0.47 -9.38 -0.46 1.07e-18 Educational attainment; LUSC trans rs7581030 0.538 rs4852777 chr2:71534161 G/C cg06465196 chr4:154387603 KIAA0922 0.42 6.03 0.31 4.3e-9 Testicular germ cell tumor; LUSC trans rs61931739 0.591 rs1608907 chr12:33945435 A/G cg26384229 chr12:38710491 ALG10B 0.52 7.77 0.39 1e-13 Morning vs. evening chronotype; LUSC cis rs2179367 0.568 rs9498358 chr6:149779665 T/C cg07828024 chr6:149772892 ZC3H12D -0.37 -6.13 -0.32 2.53e-9 Dupuytren's disease; LUSC cis rs1538970 0.962 rs9429160 chr1:45827968 G/T cg05343316 chr1:45956843 TESK2 0.61 8.61 0.43 2.97e-16 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06456258 chr22:39898429 SMCR7L -0.42 -6.39 -0.33 5.49e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg08392591 chr16:89556376 ANKRD11 0.5 7.84 0.39 6.01e-14 Multiple myeloma (IgH translocation); LUSC cis rs12368653 0.583 rs7952989 chr12:58095989 T/C cg18357645 chr12:58087776 OS9 0.43 6.51 0.34 2.83e-10 Multiple sclerosis; LUSC cis rs7202877 0.519 rs3743606 chr16:75335474 C/A cg03315344 chr16:75512273 CHST6 0.44 6.07 0.32 3.46e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs8077889 0.917 rs9901676 chr17:41911818 T/C cg26893861 chr17:41843967 DUSP3 0.88 13.71 0.6 3.12e-34 Triglycerides; LUSC cis rs7241530 0.662 rs6506753 chr18:75904851 G/A cg14642773 chr18:75888474 NA 0.39 6.0 0.31 5.05e-9 Educational attainment (years of education); LUSC cis rs9818941 0.748 rs12634315 chr3:157728016 T/C cg08654915 chr3:157813417 NA -0.32 -7.39 -0.37 1.23e-12 Height; LUSC cis rs9300255 0.602 rs2682431 chr12:123703226 T/A cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.59 8.43 0.42 1.02e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7633857 0.512 rs1868109 chr3:160682500 G/A cg03342759 chr3:160939853 NMD3 -0.37 -5.65 -0.3 3.44e-8 Educational attainment (years of education); LUSC cis rs7119038 0.731 rs28409215 chr11:118679304 G/A cg19308663 chr11:118741387 NA 0.36 6.44 0.33 4.09e-10 Sjögren's syndrome; LUSC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.35 0.37 1.5e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg06784218 chr1:46089804 CCDC17 0.48 9.35 0.46 1.3e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11997175 0.646 rs7005018 chr8:33700210 A/G ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.2e-10 Body mass index; LUSC cis rs2445762 0.642 rs8025191 chr15:51623785 A/G cg07517944 chr15:51633816 GLDN 0.41 6.81 0.35 4.42e-11 Hormone measurements; LUSC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.29 -6.02 -0.31 4.48e-9 Cystic fibrosis severity; LUSC cis rs983392 0.631 rs7107627 chr11:60041296 T/A cg24026212 chr11:59952134 MS4A6A 0.37 6.36 0.33 6.66e-10 Alzheimer's disease (late onset); LUSC cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 20.5 0.75 4.82e-61 Cognitive ability; LUSC cis rs9788721 0.640 rs1394371 chr15:78724469 C/T cg18825076 chr15:78729989 IREB2 -0.55 -8.36 -0.42 1.72e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs10504073 0.584 rs4873307 chr8:49950417 C/T cg00325661 chr8:49890786 NA 0.71 11.46 0.53 7.19e-26 Blood metabolite ratios; LUSC cis rs950776 0.518 rs12916999 chr15:78826912 C/T cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg18132916 chr6:79620363 NA -0.38 -5.83 -0.3 1.28e-8 Intelligence (multi-trait analysis); LUSC cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg04998671 chr14:104000505 TRMT61A 0.4 5.88 0.31 1.01e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg09796270 chr17:17721594 SREBF1 -0.42 -7.27 -0.37 2.54e-12 Total body bone mineral density; LUSC trans rs17133449 0.696 rs10904325 chr10:4751327 G/T cg17844448 chr7:27782764 TAX1BP1 0.4 6.63 0.34 1.38e-10 Major depressive disorder; LUSC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13721600 chr17:29151762 CRLF3 0.87 7.55 0.38 4.2e-13 Cognitive performance; LUSC cis rs7511006 0.859 rs7292228 chr22:50649560 C/G cg16473166 chr22:50639996 SELO 0.66 9.31 0.45 1.72e-18 Obesity-related traits; LUSC cis rs60154123 0.730 rs679042 chr1:210457122 A/G cg22029157 chr1:209979665 IRF6 0.52 5.96 0.31 6.32e-9 Coronary artery disease; LUSC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -7.1 -0.36 7.45e-12 Alzheimer's disease (late onset); LUSC cis rs3849570 1.000 rs7638516 chr3:81826249 A/C cg07356753 chr3:81810745 GBE1 -0.57 -9.04 -0.44 1.26e-17 Waist circumference;Body mass index; LUSC trans rs8072100 0.840 rs9900360 chr17:45491979 C/T cg03886242 chr7:26192032 NFE2L3 -0.39 -6.38 -0.33 5.77e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4566357 1.000 rs3765192 chr2:227927536 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.79 -0.3 1.61e-8 Coronary artery disease; LUSC cis rs34330 0.562 rs17212236 chr12:12855483 G/C cg04607235 chr12:12878440 APOLD1 -0.56 -6.38 -0.33 5.81e-10 Systemic lupus erythematosus; LUSC cis rs77106637 0.929 rs1059000 chr11:72504972 G/C cg04827223 chr11:72435913 ARAP1 -0.71 -8.97 -0.44 2.19e-17 Type 2 diabetes; LUSC cis rs1971762 0.523 rs7135101 chr12:54080605 G/A cg23533419 chr12:54090519 NA -0.38 -6.2 -0.32 1.64e-9 Height; LUSC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg18758796 chr5:131593413 PDLIM4 0.4 6.73 0.35 7.29e-11 Breast cancer; LUSC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg09365446 chr1:150670422 GOLPH3L 0.51 7.5 0.38 5.68e-13 Melanoma; LUSC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.93 0.31 7.57e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg09184832 chr6:79620586 NA -0.43 -6.97 -0.36 1.66e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg08677398 chr8:58056175 NA 0.53 6.98 0.36 1.61e-11 Developmental language disorder (linguistic errors); LUSC cis rs4595586 0.545 rs9668716 chr12:39378833 G/T cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs9811920 0.965 rs9849632 chr3:99867211 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 6.87 0.35 3.18e-11 Axial length; LUSC cis rs2832077 1.000 rs12329875 chr21:30137796 C/T cg24692254 chr21:30365293 RNF160 -0.55 -6.79 -0.35 5.11e-11 Cognitive test performance; LUSC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg24881330 chr22:46731750 TRMU 0.89 8.95 0.44 2.52e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 0.927 rs1906135 chr12:34038103 C/A cg13010199 chr12:38710504 ALG10B -0.4 -6.01 -0.31 4.99e-9 Morning vs. evening chronotype; LUSC cis rs7246967 0.673 rs7254097 chr19:22865900 T/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20637919 chr8:12613290 LONRF1 0.74 6.59 0.34 1.73e-10 Cognitive performance; LUSC cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg26380479 chr7:97908229 NA -0.28 -6.37 -0.33 6.43e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC trans rs12210905 1.000 rs9348756 chr6:27228259 G/A cg11837749 chr1:55047332 ACOT11 0.59 5.96 0.31 6.42e-9 Hip circumference adjusted for BMI; LUSC trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg03929089 chr4:120376271 NA -0.77 -10.43 -0.5 3.05e-22 Coronary artery disease; LUSC cis rs76878669 0.561 rs11823140 chr11:66098322 G/T cg18002602 chr11:66138449 SLC29A2 -0.44 -7.7 -0.39 1.51e-13 Educational attainment (years of education); LUSC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg12463550 chr7:65579703 CRCP 0.51 7.37 0.37 1.33e-12 Aortic root size; LUSC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.6 -7.53 -0.38 4.69e-13 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg15352829 chr14:105391018 PLD4 0.41 8.49 0.42 6.99e-16 Rheumatoid arthritis; LUSC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg12463550 chr7:65579703 CRCP 0.46 6.79 0.35 5.29e-11 Aortic root size; LUSC cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg24112000 chr20:60950667 NA -0.48 -9.41 -0.46 8.19e-19 Colorectal cancer; LUSC cis rs2667011 0.818 rs2715923 chr2:160845721 A/G cg06573604 chr2:160760825 LY75 0.49 6.49 0.33 3.16e-10 Bilirubin levels; LUSC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.36 6.93 0.35 2.24e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.56 0.42 4.06e-16 Motion sickness; LUSC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg20607287 chr7:12443886 VWDE -0.59 -6.06 -0.31 3.64e-9 Coronary artery disease; LUSC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg22467129 chr15:76604101 ETFA -0.46 -7.24 -0.37 3.21e-12 Blood metabolite levels; LUSC trans rs6502050 0.835 rs9900128 chr17:80087920 A/T cg07393940 chr7:158741817 NA 0.37 6.7 0.34 8.88e-11 Life satisfaction; LUSC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 13.69 0.6 3.45e-34 Alzheimer's disease; LUSC cis rs3126085 0.935 rs12027807 chr1:152253726 C/G cg26876637 chr1:152193138 HRNR 0.46 6.38 0.33 6.03e-10 Atopic dermatitis; LUSC cis rs4474465 1.000 rs7929712 chr11:78158542 T/C cg27205649 chr11:78285834 NARS2 -0.5 -5.94 -0.31 7.09e-9 Alzheimer's disease (survival time); LUSC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg00129232 chr17:37814104 STARD3 -0.4 -5.83 -0.3 1.31e-8 Asthma; LUSC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.6 0.47 1.97e-19 Bipolar disorder; LUSC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg22535103 chr8:58192502 C8orf71 -0.75 -7.79 -0.39 8.27e-14 Developmental language disorder (linguistic errors); LUSC trans rs6089829 0.962 rs4809462 chr20:61661560 A/G cg23505145 chr19:12996616 KLF1 0.63 10.59 0.5 8.41e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs950027 0.620 rs1145093 chr15:45649813 C/A cg04036182 chr15:45458818 NA 0.35 5.75 0.3 2.01e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs7904368 0.754 rs7076779 chr10:16852667 C/T cg14835575 chr10:16859367 RSU1 0.72 9.38 0.46 1.06e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC trans rs2700987 0.669 rs10279336 chr7:37389523 G/A cg26076750 chr5:98105150 RGMB -0.36 -6.58 -0.34 1.86e-10 Psoriasis vulgaris;Psoriasis; LUSC cis rs4077515 0.504 rs10870164 chr9:139315682 C/T cg14169450 chr9:139327907 INPP5E -0.46 -8.27 -0.41 3.29e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6500395 0.963 rs6500405 chr16:48690486 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs10225885 chr7:91671007 A/G cg17063962 chr7:91808500 NA 0.59 9.25 0.45 2.75e-18 Breast cancer; LUSC cis rs2708977 0.842 rs10209780 chr2:97140142 T/G cg01950434 chr2:97203154 ARID5A -0.53 -7.8 -0.39 7.89e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2073300 1.000 rs6048826 chr20:23458050 C/A cg09953122 chr20:23471693 CST8 -0.69 -6.87 -0.35 3.24e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg01849466 chr14:104193079 ZFYVE21 -0.61 -10.37 -0.49 4.98e-22 Schizophrenia; LUSC trans rs9393777 0.920 rs13196692 chr6:27379119 C/T cg06606381 chr12:133084897 FBRSL1 -1.02 -9.19 -0.45 4.27e-18 Intelligence (multi-trait analysis); LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg14092988 chr3:52407081 DNAH1 0.33 5.86 0.31 1.1e-8 Bipolar disorder; LUSC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg11764359 chr7:65958608 NA 0.68 10.95 0.51 4.86e-24 Aortic root size; LUSC cis rs12701220 0.842 rs10236293 chr7:1032637 G/A cg20821713 chr7:1055600 C7orf50 -0.55 -6.79 -0.35 5.2e-11 Bronchopulmonary dysplasia; LUSC cis rs66887589 0.660 rs4833613 chr4:120150156 A/C cg09307838 chr4:120376055 NA -0.45 -6.72 -0.34 8e-11 Diastolic blood pressure; LUSC cis rs7267979 1.000 rs4815412 chr20:25350325 A/G cg03522245 chr20:25566470 NINL 0.36 5.75 0.3 2.05e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9467773 0.626 rs9379860 chr6:26370605 T/C cg09904177 chr6:26538194 HMGN4 -0.49 -7.74 -0.39 1.19e-13 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.98 0.31 5.72e-9 Menopause (age at onset); LUSC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg18190219 chr22:46762943 CELSR1 -0.55 -6.28 -0.33 1.05e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4909189 1.000 rs62493649 chr7:158135556 C/G cg24154853 chr7:158122151 PTPRN2 0.35 5.77 0.3 1.82e-8 Response to amphetamines; LUSC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg16405210 chr4:1374714 KIAA1530 -0.53 -8.02 -0.4 1.84e-14 Obesity-related traits; LUSC cis rs11155671 0.530 rs9371215 chr6:150194298 C/T cg09699651 chr6:150184138 LRP11 0.38 5.9 0.31 8.9e-9 Testicular germ cell tumor; LUSC cis rs11758351 0.866 rs11757394 chr6:26206694 G/C cg01420254 chr6:26195488 NA 0.68 7.52 0.38 5.21e-13 Gout;Renal underexcretion gout; LUSC cis rs7568458 0.684 rs7608074 chr2:85809703 T/G cg02493740 chr2:85810744 VAMP5 -0.52 -9.02 -0.44 1.49e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11024102 1.000 rs10766368 chr11:17014882 G/C cg15084286 chr11:17036142 PLEKHA7 0.45 6.08 0.32 3.22e-9 Glaucoma (primary angle closure); LUSC cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.45 1.43e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7674212 0.541 rs4699051 chr4:104114394 T/C cg16532752 chr4:104119610 CENPE -0.49 -7.08 -0.36 8.68e-12 Type 2 diabetes; LUSC cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg11266682 chr4:10021025 SLC2A9 0.54 9.71 0.47 8.49e-20 Bone mineral density; LUSC cis rs911119 1.000 rs67567111 chr20:23619075 G/T cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC trans rs7657257 1.000 rs16892283 chr4:15731534 A/G cg17675199 chr6:35436792 RPL10A -0.84 -6.08 -0.32 3.37e-9 Blood protein levels; LUSC cis rs897984 0.760 rs11076 chr16:30995528 A/G cg02466173 chr16:30829666 NA 0.56 11.3 0.53 2.63e-25 Dementia with Lewy bodies; LUSC cis rs17401966 0.540 rs4846219 chr1:10463888 C/A cg19773385 chr1:10388646 KIF1B -0.41 -7.1 -0.36 7.74e-12 Hepatocellular carcinoma; LUSC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg26587870 chr6:27730563 NA -0.66 -5.92 -0.31 8.07e-9 Depression; LUSC trans rs8002861 0.967 rs9533690 chr13:44480598 T/C cg17145862 chr1:211918768 LPGAT1 0.23 6.1 0.32 2.97e-9 Leprosy; LUSC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg07959070 chr22:50026188 C22orf34 -0.34 -6.93 -0.35 2.19e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2760061 0.624 rs10442629 chr1:228191070 T/A cg01973587 chr1:228161476 NA -0.35 -5.65 -0.3 3.5e-8 Diastolic blood pressure; LUSC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg05373962 chr22:49881684 NA -0.44 -10.74 -0.51 2.5e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs394563 0.726 rs366905 chr6:149735097 T/A cg11245181 chr6:149772854 ZC3H12D -0.31 -6.66 -0.34 1.13e-10 Dupuytren's disease; LUSC cis rs9300255 0.739 rs1980252 chr12:123745178 C/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.21 -0.32 1.59e-9 Neutrophil percentage of white cells; LUSC cis rs11971779 0.680 rs11980313 chr7:139034643 C/G cg23387468 chr7:139079360 LUC7L2 0.41 6.25 0.32 1.25e-9 Diisocyanate-induced asthma; LUSC cis rs6537837 0.838 rs6663547 chr1:110114229 A/C cg05049280 chr1:110155535 GNAT2 0.46 6.28 0.33 1.03e-9 Major depressive disorder; LUSC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg04362960 chr10:104952993 NT5C2 0.53 6.5 0.34 2.92e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg12560992 chr17:57184187 TRIM37 0.83 15.3 0.64 2e-40 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs6456156 0.586 rs6456150 chr6:167468922 A/G cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16671877 chr6:116421702 NT5DC1 0.39 6.18 0.32 1.88e-9 Triglycerides; LUSC cis rs921968 0.565 rs6436081 chr2:219637884 A/G cg02176678 chr2:219576539 TTLL4 -0.55 -9.69 -0.47 1.03e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs6722750 0.716 rs2037863 chr2:64416263 G/A cg22352474 chr2:64371530 PELI1 -0.53 -7.96 -0.4 2.76e-14 Neuroticism; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg24675658 chr1:53192096 ZYG11B 0.81 13.73 0.6 2.53e-34 Monocyte count; LUSC cis rs3818285 0.679 rs2475275 chr10:111633979 C/T cg00817464 chr10:111662876 XPNPEP1 0.73 12.94 0.58 2.55e-31 Superior crus of antihelix expression; LUSC cis rs7678296 0.649 rs60691639 chr4:37239925 T/C cg06805348 chr4:37245195 KIAA1239 0.58 5.93 0.31 7.46e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg06671706 chr8:8559999 CLDN23 -0.44 -5.92 -0.31 7.81e-9 Obesity-related traits; LUSC cis rs72781680 0.898 rs72798064 chr2:23982832 T/C cg20701182 chr2:24300061 SF3B14 0.57 6.01 0.31 4.78e-9 Lymphocyte counts; LUSC trans rs11098499 0.866 rs9991221 chr4:120292107 G/C cg25214090 chr10:38739885 LOC399744 0.49 7.53 0.38 4.82e-13 Corneal astigmatism; LUSC cis rs7215564 0.908 rs35725122 chr17:78663275 A/T cg09596252 chr17:78655493 RPTOR 0.53 5.85 0.31 1.15e-8 Myopia (pathological); LUSC cis rs6121246 0.954 rs7266148 chr20:30431070 G/T cg13852791 chr20:30311386 BCL2L1 0.83 10.76 0.51 2.28e-23 Mean corpuscular hemoglobin; LUSC cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg00631329 chr6:26305371 NA -0.46 -9.18 -0.45 4.58e-18 Educational attainment; LUSC cis rs9392556 0.829 rs649725 chr6:4109593 A/C cg08342332 chr6:4079704 C6orf201;C6orf146 0.33 5.65 0.3 3.45e-8 Blood metabolite levels; LUSC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg16797656 chr11:68205561 LRP5 0.4 7.25 0.37 2.99e-12 Total body bone mineral density; LUSC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg03709012 chr19:19516395 GATAD2A 0.87 14.83 0.63 1.38e-38 Tonsillectomy; LUSC cis rs7647973 1.000 rs2140270 chr3:49439440 A/G cg07636037 chr3:49044803 WDR6 -0.69 -9.2 -0.45 4.05e-18 Menarche (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13320518 chr10:114207009 VTI1A;ZDHHC6 0.79 6.68 0.34 1.02e-10 Cognitive performance; LUSC cis rs8062405 0.755 rs4788076 chr16:28570005 C/T cg07382826 chr16:28625726 SULT1A1 0.28 6.0 0.31 5.11e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.51 0.67 3.48e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg03146154 chr1:46216737 IPP -0.57 -8.28 -0.41 2.94e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg26384229 chr12:38710491 ALG10B 0.94 17.98 0.7 4.92e-51 Heart rate; LUSC cis rs977987 0.806 rs2903033 chr16:75389606 T/A cg04384234 chr16:75411784 CFDP1 -0.39 -6.17 -0.32 1.95e-9 Dupuytren's disease; LUSC cis rs1256061 0.603 rs1256044 chr14:64734027 G/A cg23250157 chr14:64679961 SYNE2 0.32 5.71 0.3 2.56e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs2204008 0.837 rs7308714 chr12:38274307 T/C cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.74e-9 Bladder cancer; LUSC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg09455208 chr3:40491958 NA -0.54 -9.67 -0.47 1.13e-19 Renal cell carcinoma; LUSC cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg06784218 chr1:46089804 CCDC17 0.54 11.15 0.52 9.22e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs9329221 0.905 rs6601451 chr8:10243681 C/G cg15556689 chr8:8085844 FLJ10661 -0.58 -8.95 -0.44 2.55e-17 Neuroticism; LUSC cis rs1775715 0.737 rs2799018 chr10:32202069 C/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.66 0.34 1.12e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg23758822 chr17:41437982 NA 1.03 19.53 0.73 3.31e-57 Menopause (age at onset); LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.93 0.55 1.49e-27 Prudent dietary pattern; LUSC cis rs7828089 0.744 rs10108011 chr8:22320806 C/T cg12081754 chr8:22256438 SLC39A14 0.42 6.37 0.33 6.4e-10 Verbal declarative memory; LUSC cis rs1172822 0.665 rs897794 chr19:55831576 A/C cg04391588 chr19:55832610 TMEM150B 0.29 5.79 0.3 1.65e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg26462404 chr19:2270807 OAZ1 0.43 5.98 0.31 5.68e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11190604 1.000 rs4919465 chr10:102221703 C/T cg16342193 chr10:102329863 NA -0.35 -6.39 -0.33 5.63e-10 Palmitoleic acid (16:1n-7) levels; LUSC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg03929089 chr4:120376271 NA -0.93 -16.14 -0.66 9.76e-44 Height; LUSC cis rs9303280 0.806 rs4795395 chr17:37962987 T/A cg19468946 chr17:37922297 IKZF3 -0.46 -7.32 -0.37 1.88e-12 Self-reported allergy; LUSC trans rs9380880 0.826 rs2273062 chr6:39550935 C/A cg09045552 chr2:169506620 LASS6 0.73 6.56 0.34 2.11e-10 Immune response to smallpox vaccine (IL-6); LUSC cis rs2629540 0.847 rs10901807 chr10:126384610 G/A cg08799069 chr10:126477246 METTL10 0.61 8.22 0.41 4.52e-15 Cocaine dependence; LUSC cis rs7577696 0.962 rs212739 chr2:32404703 A/G cg02381751 chr2:32503542 YIPF4 0.4 5.77 0.3 1.82e-8 Inflammatory biomarkers; LUSC cis rs611744 0.604 rs6469170 chr8:109305277 T/C cg21045802 chr8:109455806 TTC35 0.48 7.57 0.38 3.76e-13 Dupuytren's disease; LUSC cis rs600231 0.708 rs1784860 chr11:65240712 C/A cg17120908 chr11:65337727 SSSCA1 -0.53 -9.23 -0.45 3.22e-18 Bone mineral density; LUSC cis rs5758511 0.637 rs5751244 chr22:42617411 T/C cg00645731 chr22:42541494 CYP2D7P1 0.55 9.69 0.47 9.98e-20 Birth weight; LUSC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.06e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg22532475 chr10:104410764 TRIM8 -0.35 -7.76 -0.39 1.01e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7582180 0.764 rs13006224 chr2:100917109 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.69 -0.43 1.66e-16 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.55 -8.28 -0.41 3.02e-15 Gut microbiome composition (summer); LUSC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg06618935 chr21:46677482 NA -0.39 -7.97 -0.4 2.6e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3808502 0.647 rs7821302 chr8:11236572 T/A cg21775007 chr8:11205619 TDH -0.65 -10.36 -0.49 5.25e-22 Neuroticism; LUSC cis rs929354 0.742 rs3808317 chr7:156944460 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC trans rs11764590 0.543 rs55893771 chr7:2096255 C/T cg10840412 chr1:235813424 GNG4 0.53 6.39 0.33 5.55e-10 Neuroticism; LUSC cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg24642439 chr20:33292090 TP53INP2 -0.54 -8.1 -0.41 1.05e-14 Height; LUSC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg00745463 chr17:30367425 LRRC37B -0.77 -9.18 -0.45 4.6e-18 Hip circumference adjusted for BMI; LUSC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg12463550 chr7:65579703 CRCP 0.5 7.28 0.37 2.41e-12 Aortic root size; LUSC cis rs13256369 0.708 rs11783670 chr8:8559394 G/A cg00074818 chr8:8560427 CLDN23 0.59 9.56 0.46 2.63e-19 Obesity-related traits; LUSC cis rs6598955 0.671 rs7417505 chr1:26575523 A/G cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs7246967 0.551 rs56968124 chr19:22814449 T/C cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs796364 0.806 rs10931890 chr2:201102055 C/T cg23649088 chr2:200775458 C2orf69 -0.56 -6.78 -0.35 5.52e-11 Schizophrenia; LUSC trans rs561341 1.000 rs535151 chr17:30317405 C/T cg20587970 chr11:113659929 NA -1.04 -13.97 -0.61 3.13e-35 Hip circumference adjusted for BMI; LUSC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg04733989 chr22:42467013 NAGA 0.59 9.16 0.45 5.24e-18 Schizophrenia; LUSC cis rs1443512 0.796 rs1822437 chr12:54340077 A/G cg25024717 chr12:54324583 NA 0.41 6.61 0.34 1.56e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg25204440 chr1:209979598 IRF6 -0.39 -5.73 -0.3 2.2e-8 Monobrow; LUSC cis rs748404 0.697 rs546170 chr15:43564849 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.42 5.9 0.31 9.13e-9 Lung cancer; LUSC cis rs34779708 0.931 rs10466072 chr10:35402756 C/T cg04310649 chr10:35416472 CREM -0.41 -6.49 -0.33 3.13e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg22442454 chr1:209979470 IRF6 0.44 5.9 0.31 8.81e-9 Cleft lip with or without cleft palate; LUSC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg04287289 chr16:89883240 FANCA 0.77 13.48 0.59 2.32e-33 Vitiligo; LUSC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg10295955 chr4:187884368 NA -1.07 -25.94 -0.82 4.9e-82 Lobe attachment (rater-scored or self-reported); LUSC cis rs73129298 0.515 rs4647955 chr20:48599561 G/C cg25655593 chr20:48599521 SNAI1 0.59 6.27 0.32 1.11e-9 Inflammatory skin disease; LUSC cis rs1728785 1.000 rs1645936 chr16:68563743 A/G cg02972257 chr16:68554789 NA -0.44 -5.76 -0.3 1.94e-8 Ulcerative colitis; LUSC cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04643909 chr4:39640571 C4orf34 -0.44 -6.58 -0.34 1.79e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10191773 0.535 rs72833432 chr2:113102746 T/C cg24977338 chr2:113188963 RGPD8;RGPD5 -0.63 -7.6 -0.38 3.06e-13 Yeast infection; LUSC cis rs1577917 1.000 rs12209127 chr6:86724427 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.08 -0.36 8.81e-12 Response to antipsychotic treatment; LUSC cis rs12541635 1.000 rs1366965 chr8:107085224 T/A cg10147462 chr8:107024639 NA -0.47 -8.61 -0.43 2.99e-16 Age of smoking initiation; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg11494091 chr17:61959527 GH2 0.64 13.57 0.6 1.06e-33 Prudent dietary pattern; LUSC cis rs500891 0.525 rs12524172 chr6:84069668 C/T cg08257003 chr6:84140564 ME1 0.35 8.62 0.43 2.8e-16 Platelet-derived growth factor BB levels; LUSC cis rs2742234 0.541 rs11238476 chr10:43711436 G/T cg02780029 chr10:43622663 RET 0.34 5.66 0.3 3.23e-8 Hirschsprung disease; LUSC cis rs12711979 0.740 rs6711963 chr2:3820915 A/T cg17052675 chr2:3827356 NA -0.58 -11.38 -0.53 1.42e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg03576123 chr11:487126 PTDSS2 -1.13 -11.88 -0.55 2.18e-27 Body mass index; LUSC cis rs7973719 0.833 rs7962563 chr12:7353514 G/A cg07052231 chr12:7363540 PEX5 0.54 9.44 0.46 6.79e-19 IgG glycosylation; LUSC cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg05340658 chr4:99064831 C4orf37 0.6 10.2 0.49 1.85e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7202877 0.706 rs247434 chr16:75445304 G/A cg03315344 chr16:75512273 CHST6 -0.46 -6.34 -0.33 7.24e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.12e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs79976124 0.837 rs10455591 chr6:66650584 A/G cg07460842 chr6:66804631 NA 0.73 9.11 0.45 7.89e-18 Type 2 diabetes; LUSC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg13944838 chr5:179740914 GFPT2 -0.64 -10.28 -0.49 1.03e-21 Height; LUSC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4845570 1.000 rs3811415 chr1:151763767 C/T cg07092448 chr1:151763213 TDRKH -1.28 -14.39 -0.62 7.46e-37 Coronary artery disease; LUSC cis rs2637266 0.935 rs2579719 chr10:78400026 A/G cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs5769765 0.908 rs4824109 chr22:50271460 T/C cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs16976116 0.951 rs6493768 chr15:55484294 T/A cg11288833 chr15:55489084 RSL24D1 0.54 6.48 0.33 3.35e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6542838 0.641 rs4850890 chr2:99535426 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.54 -7.53 -0.38 4.65e-13 Fear of minor pain; LUSC cis rs3774749 0.565 rs2518795 chr3:50208819 C/T cg14019146 chr3:50243930 SLC38A3 -0.45 -10.56 -0.5 1.12e-22 Intelligence (multi-trait analysis); LUSC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg03351412 chr1:154909251 PMVK 0.51 8.03 0.4 1.7e-14 Prostate cancer; LUSC cis rs11645898 0.504 rs75888697 chr16:71985222 A/C cg14768367 chr16:72042858 DHODH -0.59 -5.67 -0.3 3.05e-8 Blood protein levels; LUSC trans rs11992162 0.551 rs13268217 chr8:11782609 T/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.76 -0.35 6.16e-11 Monocyte count; LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg05025164 chr4:1340916 KIAA1530 0.48 7.39 0.37 1.17e-12 Obesity-related traits; LUSC cis rs8060686 0.591 rs255054 chr16:68017356 A/G cg27539214 chr16:67997921 SLC12A4 -0.44 -5.74 -0.3 2.08e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg10018233 chr7:150070692 REPIN1 0.38 6.61 0.34 1.48e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs6500602 0.702 rs6500606 chr16:4502514 A/G cg08645402 chr16:4508243 NA -0.53 -9.14 -0.45 6.15e-18 Schizophrenia; LUSC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg04455712 chr21:45112962 RRP1B 0.47 8.96 0.44 2.42e-17 Mean corpuscular volume; LUSC trans rs1864729 1.000 rs2583504 chr8:98283404 G/C cg08679828 chr8:102218111 ZNF706 -0.85 -7.71 -0.39 1.45e-13 Estradiol plasma levels (breast cancer); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00772840 chr19:15490660 AKAP8 -0.41 -6.18 -0.32 1.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs75920871 0.528 rs12279066 chr11:116913909 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.37 -0.33 6.26e-10 Subjective well-being; LUSC cis rs478304 0.934 rs517115 chr11:65526988 C/T cg27068330 chr11:65405492 SIPA1 0.64 9.66 0.47 1.28e-19 Acne (severe); LUSC cis rs1595825 0.891 rs111340803 chr2:198612877 A/G cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 5.92e-9 Ulcerative colitis; LUSC cis rs912057 0.526 rs737449 chr6:6733729 A/G cg06612196 chr6:6737390 NA -0.6 -12.24 -0.56 1.02e-28 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC cis rs4780401 0.728 rs8057398 chr16:11780629 G/T cg01061890 chr16:11836724 TXNDC11 -0.43 -6.0 -0.31 5.21e-9 Rheumatoid arthritis; LUSC cis rs7830933 0.780 rs1561105 chr8:23610799 T/G cg04349084 chr8:23602677 NA 0.36 5.88 0.31 9.75e-9 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg03790207 chr6:42947109 PEX6 -0.47 -7.17 -0.37 4.75e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg15423357 chr2:25149977 NA 0.45 9.13 0.45 6.59e-18 Body mass index; LUSC cis rs34816374 1 rs34816374 chr6:26949672 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.58 -5.72 -0.3 2.35e-8 Lung cancer in ever smokers; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.5 -7.3 -0.37 2.11e-12 Renal function-related traits (BUN); LUSC cis rs9388451 0.874 rs13209968 chr6:126089285 G/C cg05901451 chr6:126070800 HEY2 -0.95 -18.88 -0.72 1.25e-54 Brugada syndrome; LUSC cis rs7674212 0.507 rs223361 chr4:103769304 T/C cg16532752 chr4:104119610 CENPE -0.41 -5.7 -0.3 2.64e-8 Type 2 diabetes; LUSC cis rs6964587 0.967 rs10246036 chr7:91558523 G/A cg17063962 chr7:91808500 NA -0.56 -8.62 -0.43 2.7e-16 Breast cancer; LUSC cis rs62408225 0.722 rs2064870 chr6:90903990 T/C cg06866423 chr6:90926672 BACH2 0.41 6.49 0.33 3.01e-10 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg10802521 chr3:52805072 NEK4 -0.52 -8.38 -0.42 1.51e-15 Bipolar disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01526870 chr12:12510070 LOH12CR1;LOH12CR2 0.81 6.26 0.32 1.21e-9 Cognitive performance; LUSC cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg22676075 chr6:135203613 NA 0.57 8.91 0.44 3.27e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg04586622 chr2:25135609 ADCY3 0.42 8.96 0.44 2.27e-17 Body mass index; LUSC cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg05855489 chr10:104503620 C10orf26 0.53 8.19 0.41 5.5e-15 Arsenic metabolism; LUSC cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg20701182 chr2:24300061 SF3B14 0.88 11.57 0.53 3.02e-26 Lymphocyte counts; LUSC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs6599077 0.950 rs60037145 chr3:40102918 C/T cg13683864 chr3:40499215 RPL14 -0.61 -7.6 -0.38 3.09e-13 Sleep-related phenotypes; LUSC cis rs6840360 0.593 rs1877185 chr4:152690348 C/T cg22705602 chr4:152727874 NA -0.37 -8.16 -0.41 6.99e-15 Intelligence (multi-trait analysis); LUSC cis rs9815354 1.000 rs28702390 chr3:41889920 C/A cg03022575 chr3:42003672 ULK4 0.63 6.85 0.35 3.49e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.67 0.3 3.15e-8 Schizophrenia; LUSC cis rs11676855 1.000 rs11676855 chr2:235900171 C/T cg14917874 chr2:235941519 SH3BP4 -0.49 -8.16 -0.41 7.07e-15 Dialysis-related mortality; LUSC cis rs6121246 0.909 rs57726761 chr20:30314046 A/G cg13852791 chr20:30311386 BCL2L1 0.9 12.15 0.55 2.14e-28 Mean corpuscular hemoglobin; LUSC cis rs3020736 0.500 rs6002601 chr22:42489058 A/T cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg01503450 chr10:980765 NA -0.4 -5.81 -0.3 1.45e-8 Eosinophil percentage of granulocytes; LUSC cis rs1538970 0.816 rs9727262 chr1:45998579 T/G cg05343316 chr1:45956843 TESK2 0.71 9.62 0.47 1.68e-19 Platelet count; LUSC cis rs6489882 0.867 rs4767031 chr12:113362751 C/G cg20102336 chr12:113376681 OAS3 -0.41 -5.88 -0.31 9.9e-9 Chronic lymphocytic leukemia; LUSC cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg24375607 chr4:120327624 NA -0.72 -10.85 -0.51 1.04e-23 Corneal astigmatism; LUSC cis rs7241530 0.662 rs4799261 chr18:75889293 G/A cg14642773 chr18:75888474 NA 0.36 6.01 0.31 4.91e-9 Educational attainment (years of education); LUSC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg02034447 chr16:89574710 SPG7 0.44 6.5 0.34 2.89e-10 Multiple myeloma (IgH translocation); LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg25258033 chr6:167368657 RNASET2 0.49 8.1 0.41 1.04e-14 Crohn's disease; LUSC cis rs12618769 0.597 rs3754880 chr2:99132215 G/C cg10123293 chr2:99228465 UNC50 0.45 7.43 0.38 8.89e-13 Bipolar disorder; LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg10802521 chr3:52805072 NEK4 -0.54 -8.62 -0.43 2.82e-16 Bipolar disorder; LUSC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -6.13 -0.32 2.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11644478 chr21:40555479 PSMG1 0.94 18.21 0.71 5.78e-52 Cognitive function; LUSC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg16262614 chr3:133464971 TF 0.43 7.64 0.39 2.28e-13 Iron status biomarkers; LUSC cis rs116988415 0.584 rs4902310 chr14:65241906 T/C cg00114569 chr14:65239327 SPTB 0.66 6.4 0.33 5.23e-10 Daytime sleep phenotypes; LUSC cis rs4073582 0.595 rs9326370 chr11:65992008 A/G cg16950941 chr11:66035639 RAB1B 0.48 7.1 0.36 7.32e-12 Gout; LUSC cis rs9311676 0.609 rs62258080 chr3:58367493 G/A cg13750441 chr3:58318267 PXK 0.36 6.86 0.35 3.33e-11 Systemic lupus erythematosus; LUSC cis rs3772130 0.962 rs13061326 chr3:121493125 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.23 0.49 1.48e-21 Cognitive performance; LUSC cis rs3812831 0.630 rs9562129 chr13:114917152 A/G cg08824895 chr13:115047677 UPF3A 0.54 8.2 0.41 5.38e-15 Schizophrenia; LUSC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg12963246 chr6:28129442 ZNF389 0.49 6.73 0.35 7.47e-11 Depression; LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg02018176 chr4:1364513 KIAA1530 0.52 9.14 0.45 6.36e-18 Obesity-related traits; LUSC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg23719950 chr11:63933701 MACROD1 -0.55 -7.48 -0.38 6.61e-13 Mean platelet volume; LUSC cis rs4561483 0.583 rs11075030 chr16:11976414 C/A cg08843971 chr16:11963173 GSPT1 0.41 6.25 0.32 1.22e-9 Testicular germ cell tumor; LUSC cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.06 0.58 9.04e-32 Chronic sinus infection; LUSC cis rs4144027 0.791 rs66473563 chr14:104361871 C/T cg12183467 chr14:104352244 NA 0.3 6.01 0.31 4.97e-9 Blood metabolite levels; LUSC cis rs501916 0.634 rs61333299 chr15:48066806 G/A cg16110827 chr15:48056943 SEMA6D -0.38 -5.98 -0.31 5.89e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs3099143 0.908 rs6495222 chr15:77180015 A/C cg21673338 chr15:77095150 SCAPER 0.81 7.7 0.39 1.56e-13 Recalcitrant atopic dermatitis; LUSC cis rs2073300 1.000 rs6132628 chr20:23446734 G/A cg09953122 chr20:23471693 CST8 -0.86 -7.29 -0.37 2.21e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7246657 0.943 rs7255407 chr19:37933936 G/A cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs754466 0.606 rs11002306 chr10:79591519 A/T cg17075019 chr10:79541650 NA -0.76 -12.44 -0.56 1.83e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg15448220 chr1:150897856 SETDB1 0.39 5.86 0.31 1.11e-8 Melanoma; LUSC cis rs9650657 0.707 rs10098699 chr8:10676756 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.1 -0.32 2.85e-9 Neuroticism; LUSC trans rs3733585 0.699 rs7663079 chr4:9966771 T/C cg26043149 chr18:55253948 FECH -0.46 -7.1 -0.36 7.46e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg06850241 chr22:41845214 NA 0.34 6.14 0.32 2.38e-9 Vitiligo; LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg16325326 chr1:53192061 ZYG11B -0.91 -16.89 -0.68 1.11e-46 Monocyte count; LUSC cis rs877282 0.891 rs12357999 chr10:796468 A/C cg17470449 chr10:769945 NA 0.48 6.78 0.35 5.58e-11 Uric acid levels; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg13560548 chr3:10150139 C3orf24 0.48 6.6 0.34 1.6e-10 Alzheimer's disease; LUSC cis rs11779988 0.545 rs4124900 chr8:17785266 A/G cg01800426 chr8:17659068 MTUS1 -0.5 -6.12 -0.32 2.67e-9 Breast cancer; LUSC cis rs11871801 0.560 rs8074296 chr17:40583421 A/G cg16308533 chr17:40838983 CNTNAP1 0.37 5.8 0.3 1.52e-8 Crohn's disease; LUSC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg17211192 chr8:82754475 SNX16 0.64 9.18 0.45 4.63e-18 Diastolic blood pressure; LUSC cis rs9715521 0.677 rs67500083 chr4:59862419 C/T cg11281224 chr4:60001000 NA -0.49 -6.84 -0.35 3.81e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7909074 0.831 rs11239271 chr10:45376294 A/G cg05187965 chr10:45406764 TMEM72 -0.36 -8.47 -0.42 8.17e-16 Mean corpuscular volume; LUSC cis rs7712401 0.791 rs10063253 chr5:122128711 T/C cg19077854 chr5:122220652 SNX24 0.35 7.85 0.39 5.87e-14 Mean platelet volume; LUSC cis rs3820928 0.874 rs4675131 chr2:227836742 T/G cg11843606 chr2:227700838 RHBDD1 -0.54 -7.82 -0.39 6.77e-14 Pulmonary function; LUSC cis rs897984 0.553 rs2335013 chr16:30877346 T/G cg02466173 chr16:30829666 NA 0.53 9.04 0.44 1.29e-17 Dementia with Lewy bodies; LUSC cis rs644799 0.544 rs1254935 chr11:95631470 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.63 9.35 0.46 1.31e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9660992 0.762 rs1172137 chr1:205246061 G/T cg21545522 chr1:205238299 TMCC2 0.45 8.55 0.42 4.64e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2406342 0.528 rs75536638 chr18:74499060 G/T cg00539368 chr18:74514137 NA 0.49 6.39 0.33 5.69e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg18110333 chr6:292329 DUSP22 -0.51 -7.42 -0.38 9.73e-13 Menopause (age at onset); LUSC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11890956 chr21:40555474 PSMG1 1.03 20.73 0.75 5.92e-62 Cognitive function; LUSC cis rs4363385 0.765 rs3806221 chr1:153002555 G/T cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs887829 0.641 rs10197460 chr2:234589190 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.41 -6.6 -0.34 1.6e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs6516091 0.850 rs62199228 chr20:6047655 G/A cg25325723 chr20:6104886 FERMT1 -0.69 -7.21 -0.37 3.74e-12 Abdominal aortic aneurysm; LUSC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg22029157 chr1:209979665 IRF6 0.51 8.2 0.41 5.07e-15 Monobrow; LUSC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.95 0.55 1.23e-27 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7100689 0.784 rs4934083 chr10:82116501 G/C cg01528321 chr10:82214614 TSPAN14 1.01 15.25 0.64 3.34e-40 Post bronchodilator FEV1; LUSC cis rs1005224 0.654 rs8005753 chr14:76136086 A/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.66 -8.97 -0.44 2.15e-17 Large artery stroke; LUSC trans rs7395662 0.591 rs4882110 chr11:48558249 G/T cg03929089 chr4:120376271 NA -0.44 -6.15 -0.32 2.24e-9 HDL cholesterol; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05821866 chr1:167905319 DCAF6;BRP44 0.46 6.5 0.34 2.99e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2274273 1.000 rs3742566 chr14:55595839 T/A cg04306507 chr14:55594613 LGALS3 0.53 11.37 0.53 1.48e-25 Protein biomarker; LUSC cis rs2279817 0.820 rs12754031 chr1:18006619 G/A cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.12 -0.32 2.68e-9 Neuroticism; LUSC cis rs10779751 1.000 rs11121706 chr1:11302065 C/T cg08854313 chr1:11322531 MTOR 0.82 13.45 0.59 3.08e-33 Body mass index; LUSC cis rs7572644 0.665 rs4493211 chr2:28039472 G/T cg27432699 chr2:27873401 GPN1 0.57 7.28 0.37 2.47e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1971762 0.583 rs3852561 chr12:54085842 C/T cg23533419 chr12:54090519 NA -0.37 -6.12 -0.32 2.58e-9 Height; LUSC cis rs644799 0.544 rs555556 chr11:95618425 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.65 9.76 0.47 5.88e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.47 0.33 3.48e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.15 16.21 0.66 5.28e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg11494091 chr17:61959527 GH2 0.36 6.04 0.31 4.21e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7539409 0.651 rs7521788 chr1:84309320 G/T cg10977910 chr1:84465055 TTLL7 0.71 7.55 0.38 4.31e-13 Alzheimer's disease; LUSC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg24450063 chr1:156163899 SLC25A44 1.2 30.95 0.86 3.89e-100 Testicular germ cell tumor; LUSC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg24879335 chr3:133465180 TF 0.46 7.69 0.39 1.68e-13 Iron status biomarkers (transferrin levels); LUSC cis rs11758351 0.587 rs16891456 chr6:26234127 T/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs10737909 1.000 rs10803369 chr1:15550525 G/T cg21012057 chr1:15538911 TMEM51 -0.34 -5.7 -0.3 2.61e-8 Migraine; LUSC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11890956 chr21:40555474 PSMG1 0.72 10.91 0.51 6.63e-24 Menarche (age at onset); LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg12419862 chr22:24373484 LOC391322 -0.97 -18.75 -0.72 4.18e-54 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs9486715 0.867 rs1127175 chr6:96999725 C/T cg06623918 chr6:96969491 KIAA0776 -0.92 -17.05 -0.68 2.55e-47 Headache; LUSC cis rs12410462 0.710 rs74140145 chr1:227423946 C/T cg04117972 chr1:227635322 NA 0.48 5.76 0.3 1.86e-8 Major depressive disorder; LUSC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.62 0.47 1.69e-19 Hip circumference adjusted for BMI; LUSC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg22903471 chr2:27725779 GCKR -0.42 -7.26 -0.37 2.79e-12 Total body bone mineral density; LUSC cis rs59698941 0.943 rs739863 chr5:132232315 C/T cg02081065 chr5:132209139 LEAP2 -0.65 -7.18 -0.37 4.63e-12 Apolipoprotein A-IV levels; LUSC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg24562669 chr7:97807699 LMTK2 0.34 5.95 0.31 6.88e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.863 rs6835635 chr4:120458867 A/G cg09307838 chr4:120376055 NA 0.69 10.25 0.49 1.25e-21 Corneal astigmatism; LUSC cis rs4964805 0.913 rs35945096 chr12:104201929 G/A cg02344784 chr12:104178138 NT5DC3 0.44 7.07 0.36 9.28e-12 Attention deficit hyperactivity disorder; LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg18402987 chr7:1209562 NA 0.71 7.53 0.38 4.64e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3784262 1.000 rs4646622 chr15:58257199 A/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.8 -0.3 1.58e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2271400 0.852 rs1450741 chr8:56792159 T/C cg08894788 chr8:56792171 LYN -0.43 -6.77 -0.35 5.8e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Myeloid white cell count;Neutrophil count;Granulocyte count; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg08888203 chr3:10149979 C3orf24 0.64 8.7 0.43 1.49e-16 Alzheimer's disease; LUSC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg00677455 chr12:58241039 CTDSP2 0.62 8.81 0.43 6.8e-17 Multiple sclerosis; LUSC cis rs9814567 1.000 rs1917130 chr3:134313773 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.85 14.02 0.61 1.89e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10744422 1.000 rs3817094 chr12:123332032 T/C cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.14e-12 Schizophrenia; LUSC cis rs7789940 0.857 rs12532935 chr7:75939698 G/C cg15798862 chr7:76129360 DTX2 -0.45 -7.24 -0.37 3.05e-12 Multiple sclerosis; LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg05025164 chr4:1340916 KIAA1530 -0.67 -10.43 -0.5 3.15e-22 Longevity; LUSC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg18681998 chr4:17616180 MED28 0.85 16.06 0.66 2.03e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs929596 0.597 rs10173355 chr2:234597321 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.82 -0.39 6.93e-14 Total bilirubin levels in HIV-1 infection; LUSC cis rs6500395 1.000 rs3919552 chr16:48716328 C/T cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1371867 0.875 rs1788184 chr8:101335106 A/G cg00191853 chr8:101177733 SPAG1 -0.39 -6.47 -0.33 3.49e-10 Atrioventricular conduction; LUSC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.6 -0.34 1.6e-10 High light scatter reticulocyte count; LUSC cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg06547715 chr2:218990976 CXCR2 0.32 6.31 0.33 8.97e-10 Ulcerative colitis; LUSC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg12658694 chr1:38397304 INPP5B -0.49 -7.05 -0.36 1.05e-11 Coronary artery disease; LUSC cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg13010199 chr12:38710504 ALG10B 0.61 9.55 0.46 2.89e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs1008375 0.898 rs9998130 chr4:17593905 A/G cg18681998 chr4:17616180 MED28 0.83 14.83 0.63 1.45e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11971779 0.793 rs4732366 chr7:139027845 G/C cg07862535 chr7:139043722 LUC7L2 0.56 6.7 0.34 8.68e-11 Diisocyanate-induced asthma; LUSC cis rs826838 0.709 rs4882355 chr12:38721462 A/T cg26384229 chr12:38710491 ALG10B 0.6 9.35 0.46 1.34e-18 Heart rate; LUSC trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7103648 0.838 rs2293576 chr11:47434986 A/G cg20307385 chr11:47447363 PSMC3 -0.88 -15.01 -0.63 2.86e-39 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.61 0.34 1.5e-10 Lung cancer; LUSC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg17264618 chr3:40429014 ENTPD3 0.34 7.18 0.37 4.56e-12 Renal cell carcinoma; LUSC cis rs57590327 0.555 rs3772884 chr3:81802720 G/T cg07356753 chr3:81810745 GBE1 -0.68 -10.66 -0.5 4.89e-23 Extraversion; LUSC cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg03146154 chr1:46216737 IPP 0.5 7.49 0.38 6.02e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11098499 0.909 rs2127821 chr4:120394535 T/C cg24375607 chr4:120327624 NA 0.81 12.01 0.55 7.59e-28 Corneal astigmatism; LUSC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg20406979 chr6:167373233 NA 0.26 6.26 0.32 1.19e-9 Crohn's disease; LUSC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg23172400 chr8:95962367 TP53INP1 -0.45 -9.4 -0.46 8.89e-19 Type 2 diabetes; LUSC cis rs11711311 1.000 rs9851731 chr3:113502651 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.44 -5.91 -0.31 8.63e-9 IgG glycosylation; LUSC cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.58 -7.78 -0.39 9.21e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs8044995 0.925 rs9928653 chr16:68252079 T/C cg05110241 chr16:68378359 PRMT7 -0.47 -6.07 -0.32 3.54e-9 Schizophrenia; LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg20887711 chr4:1340912 KIAA1530 0.68 10.37 0.49 4.81e-22 Longevity; LUSC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg04369109 chr6:150039330 LATS1 -0.6 -8.83 -0.43 6.2e-17 Lung cancer; LUSC cis rs7582180 0.739 rs11123822 chr2:100911582 G/T cg08017756 chr2:100939284 LONRF2 -0.41 -7.61 -0.38 2.81e-13 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.954 rs11098526 chr4:120390359 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.23 0.32 1.4e-9 Corneal astigmatism; LUSC cis rs12760731 0.623 rs2295019 chr1:178451732 A/G cg00404053 chr1:178313656 RASAL2 0.55 6.28 0.33 1.04e-9 Obesity-related traits; LUSC trans rs9354352 0.935 rs7766730 chr6:66697003 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.64 9.19 0.45 4.34e-18 Initial pursuit acceleration in psychotic disorders; LUSC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg09658497 chr7:2847517 GNA12 -0.32 -5.72 -0.3 2.37e-8 Height; LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11302857 chr20:278071 ZCCHC3 0.76 6.17 0.32 1.93e-9 Cognitive performance; LUSC trans rs853679 0.546 rs483143 chr6:27846744 G/C cg06606381 chr12:133084897 FBRSL1 -0.75 -7.33 -0.37 1.79e-12 Depression; LUSC cis rs360798 0.512 rs2430388 chr2:63106784 T/C cg17519650 chr2:63277830 OTX1 0.51 7.06 0.36 9.79e-12 Coronary artery disease; LUSC cis rs727505 1.000 rs55964341 chr7:124517280 A/G cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs7923452 0.507 rs612802 chr10:30756441 G/A cg18806716 chr10:30721971 MAP3K8 -0.59 -9.66 -0.47 1.22e-19 Itch intensity from mosquito bite; LUSC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.26 0.37 2.67e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg23985595 chr17:80112537 CCDC57 -0.3 -5.71 -0.3 2.55e-8 Life satisfaction; LUSC cis rs10751667 0.643 rs7396767 chr11:938808 G/A ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg12011299 chr4:100065546 ADH4 0.64 10.14 0.49 3.04e-21 Alcohol dependence; LUSC cis rs9304742 0.962 rs12150933 chr19:53455221 A/G cg09915433 chr19:53449742 NA -0.61 -9.67 -0.47 1.14e-19 Psoriasis; LUSC cis rs240764 0.658 rs4463266 chr6:101223997 C/T cg09795085 chr6:101329169 ASCC3 -0.45 -6.34 -0.33 7.43e-10 Neuroticism; LUSC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg04414720 chr1:150670196 GOLPH3L 0.57 9.25 0.45 2.68e-18 Tonsillectomy; LUSC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg08280861 chr8:58055591 NA 0.57 7.2 0.37 3.94e-12 Developmental language disorder (linguistic errors); LUSC cis rs7208859 0.623 rs1061342 chr17:29114463 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs988712 0.537 rs10742179 chr11:27650524 A/G cg15471856 chr13:19448839 NA -0.45 -6.36 -0.33 6.51e-10 Obesity; LUSC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg03188948 chr7:1209495 NA 0.64 7.29 0.37 2.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg15704280 chr7:45808275 SEPT13 0.87 12.61 0.57 4.33e-30 Coronary artery disease; LUSC cis rs4727027 0.704 rs10952805 chr7:148907849 G/A cg23583168 chr7:148888333 NA -0.88 -16.6 -0.67 1.54e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9660992 0.649 rs12128229 chr1:205268014 C/A cg21643547 chr1:205240462 TMCC2 -0.51 -9.44 -0.46 6.64e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg12311346 chr5:56204834 C5orf35 -0.69 -9.75 -0.47 6.43e-20 Type 2 diabetes; LUSC cis rs7267979 1.000 rs447722 chr20:25443510 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.99 0.31 5.28e-9 Schizophrenia; LUSC cis rs144345632 1 rs144345632 chr6:96886894 T/TA cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.9e-20 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs7937682 0.575 rs34558891 chr11:111737912 C/T cg09085632 chr11:111637200 PPP2R1B 0.96 13.28 0.59 1.29e-32 Primary sclerosing cholangitis; LUSC cis rs17095355 1.000 rs12569906 chr10:111706856 A/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.62 -0.38 2.6e-13 Biliary atresia; LUSC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg09165964 chr15:75287851 SCAMP5 1.03 15.1 0.64 1.27e-39 Blood trace element (Zn levels); LUSC cis rs2730245 0.527 rs2730237 chr7:158706166 A/G cg24397884 chr7:158709396 WDR60 0.7 8.25 0.41 3.64e-15 Height; LUSC cis rs6519955 0.866 rs9626920 chr22:46428993 A/G cg05468064 chr22:46423449 NA -0.39 -6.71 -0.34 8.15e-11 Dupuytren's disease; LUSC cis rs7210086 0.768 rs4075985 chr17:70640873 C/G cg04206342 chr17:70636940 NA -0.35 -5.83 -0.3 1.28e-8 Ulcerative colitis; LUSC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 11.63 0.54 1.79e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs62103177 0.810 rs62103192 chr18:77629050 A/T cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC cis rs9399401 0.593 rs262117 chr6:142807093 G/A cg04461802 chr6:142623433 GPR126 0.44 5.72 0.3 2.41e-8 Chronic obstructive pulmonary disease; LUSC cis rs1524927 1.000 rs12704873 chr7:96336279 G/C cg03808172 chr7:96339361 SHFM1 0.43 6.66 0.34 1.12e-10 Total body bone mineral density; LUSC cis rs68170813 0.559 rs12537342 chr7:106943563 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.7 -0.47 8.88e-20 Coronary artery disease; LUSC cis rs1160297 0.576 rs12617374 chr2:53107105 C/T cg07782112 chr2:53107842 NA 0.4 6.64 0.34 1.26e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs68170813 0.641 rs77487103 chr7:107078793 T/C cg02696742 chr7:106810147 HBP1 -0.67 -9.5 -0.46 4.29e-19 Coronary artery disease; LUSC cis rs921968 0.541 rs3770216 chr2:219443717 A/G cg02176678 chr2:219576539 TTLL4 -0.76 -14.89 -0.63 8.28e-39 Mean corpuscular hemoglobin concentration; LUSC cis rs17685 0.712 rs60232511 chr7:75800082 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.42 -0.38 1.01e-12 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.32 0.41 2.2e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs295140 0.546 rs295137 chr2:201150040 C/T cg23649088 chr2:200775458 C2orf69 0.41 6.07 0.32 3.49e-9 QT interval; LUSC cis rs9325144 0.723 rs11169482 chr12:39164327 A/T cg13010199 chr12:38710504 ALG10B 0.5 7.57 0.38 3.77e-13 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6500602 0.653 rs4786487 chr16:4440397 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.47 -5.83 -0.3 1.3e-8 Schizophrenia; LUSC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg22963979 chr7:1858916 MAD1L1 -0.55 -8.46 -0.42 8.61e-16 Schizophrenia; LUSC cis rs7474896 0.526 rs1208633 chr10:38156873 A/C cg25427524 chr10:38739819 LOC399744 0.45 5.9 0.31 8.86e-9 Obesity (extreme); LUSC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg04944784 chr2:26401820 FAM59B -0.69 -9.91 -0.48 1.84e-20 Gut microbiome composition (summer); LUSC cis rs8040855 0.860 rs6496775 chr15:85708141 A/G cg04831495 chr15:85060580 GOLGA6L5 0.42 6.09 0.32 3.18e-9 Bulimia nervosa; LUSC cis rs6547741 1.000 rs6756238 chr2:27841305 G/A cg27432699 chr2:27873401 GPN1 0.8 14.96 0.63 4.51e-39 Oral cavity cancer; LUSC cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.56 0.5 1.09e-22 Schizophrenia; LUSC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg16339924 chr4:17578868 LAP3 0.64 10.13 0.48 3.35e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13319049 chr4:39699555 UBE2K -0.4 -6.17 -0.32 2.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9944715 0.911 rs9945783 chr18:43782260 T/C cg01718231 chr17:29326311 RNF135 -0.5 -7.11 -0.36 7.16e-12 Red cell distribution width;Mean corpuscular volume; LUSC trans rs9886428 1.000 rs9886428 chr8:14113816 G/A cg11959399 chr20:741723 C20orf54 -0.4 -6.45 -0.33 3.98e-10 IgG glycosylation; LUSC cis rs6460942 0.908 rs6979124 chr7:12232551 G/T cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg22507989 chr22:21356069 FLJ39582;THAP7 0.4 6.06 0.31 3.63e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg03676636 chr4:99064102 C4orf37 -0.32 -7.2 -0.37 4.01e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs12928939 0.517 rs8049508 chr16:71978313 C/T cg03805757 chr16:71968109 PKD1L3 -0.62 -9.42 -0.46 7.57e-19 Post bronchodilator FEV1; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03934478 chr11:495069 RNH1 0.91 10.47 0.5 2.32e-22 Body mass index; LUSC cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg22906224 chr7:99728672 NA 0.56 8.17 0.41 6.35e-15 Coronary artery disease; LUSC cis rs2658782 0.950 rs2446061 chr11:93149277 C/T cg15737290 chr11:93063684 CCDC67 0.65 8.08 0.4 1.19e-14 Pulmonary function decline; LUSC cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.84 -0.3 1.26e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs9291683 0.526 rs6827785 chr4:10018205 C/T cg26043149 chr18:55253948 FECH 0.48 7.22 0.37 3.5e-12 Bone mineral density; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg21226059 chr5:178986404 RUFY1 0.57 9.88 0.48 2.22e-20 Lung cancer; LUSC cis rs17030434 0.654 rs10021631 chr4:154646675 A/G cg14289246 chr4:154710475 SFRP2 -0.45 -6.3 -0.33 9.54e-10 Electrocardiographic conduction measures; LUSC cis rs7208859 0.673 rs12103759 chr17:29235687 G/A cg13385521 chr17:29058706 SUZ12P 0.59 5.7 0.3 2.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6076065 1.000 rs2405231 chr20:23342239 A/C cg11657817 chr20:23433608 CST11 0.45 8.93 0.44 2.94e-17 Facial morphology (factor 15, philtrum width); LUSC cis rs243505 1.000 rs243510 chr7:148432534 A/G cg09806900 chr7:148480153 CUL1 -0.5 -6.94 -0.36 2.02e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg21573476 chr21:45109991 RRP1B -0.41 -6.74 -0.35 7.09e-11 Mean corpuscular volume; LUSC cis rs4555082 0.915 rs66527719 chr14:105750523 C/G cg10792982 chr14:105748885 BRF1 0.48 8.44 0.42 9.88e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs9309473 0.500 rs11688718 chr2:73760939 C/T cg20560298 chr2:73613845 ALMS1 -0.51 -7.84 -0.39 5.92e-14 Metabolite levels; LUSC trans rs7078219 0.714 rs11190137 chr10:101287944 G/T cg10182584 chr2:200776745 C2orf69 -0.4 -5.98 -0.31 5.75e-9 Dental caries; LUSC cis rs3862030 0.694 rs1984795 chr10:104226830 C/T cg22532475 chr10:104410764 TRIM8 0.25 5.87 0.31 1.03e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs4950928 0.823 rs4950929 chr1:203160126 A/C cg17014757 chr1:203156097 CHI3L1 0.42 7.67 0.39 1.89e-13 YKL-40 levels; LUSC cis rs10992471 0.603 rs1980848 chr9:95248571 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.47 8.17 0.41 6.51e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg22437258 chr11:111473054 SIK2 0.53 7.53 0.38 4.93e-13 Primary sclerosing cholangitis; LUSC cis rs6504663 0.558 rs2412325 chr17:48546232 G/C cg22571038 chr17:48585470 MYCBPAP 0.44 5.69 0.3 2.72e-8 Visceral fat; LUSC cis rs7267979 0.933 rs2258728 chr20:25276343 G/A cg08601574 chr20:25228251 PYGB 0.42 6.43 0.33 4.36e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9527 0.662 rs743575 chr10:104594906 T/G cg23093090 chr10:104574429 C10orf26 -0.4 -6.79 -0.35 5.05e-11 Arsenic metabolism; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.71 12.0 0.55 7.98e-28 Prudent dietary pattern; LUSC cis rs1451375 0.617 rs10276473 chr7:50612997 A/C cg18232548 chr7:50535776 DDC -0.51 -7.06 -0.36 9.5e-12 Malaria; LUSC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg00815214 chr21:47717953 NA -0.35 -5.72 -0.3 2.33e-8 Testicular germ cell tumor; LUSC cis rs2304069 0.913 rs7734382 chr5:149383241 A/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.78 10.8 0.51 1.66e-23 HIV-1 control; LUSC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg25025879 chr12:53359317 NA -0.57 -8.69 -0.43 1.63e-16 Cancer (pleiotropy); LUSC cis rs1499972 0.941 rs56310214 chr3:117640127 G/A cg07612923 chr3:117604196 NA 0.62 5.64 0.3 3.54e-8 Schizophrenia; LUSC cis rs7759001 0.857 rs980960 chr6:27361042 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.65 0.3 3.44e-8 Glomerular filtration rate (creatinine); LUSC cis rs6712932 1.000 rs10170234 chr2:105841841 C/G cg22878388 chr2:105853796 NA -0.33 -6.0 -0.31 5.2e-9 Type 2 diabetes; LUSC cis rs9300255 0.568 rs1790108 chr12:123636841 A/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.15 -0.32 2.26e-9 Neutrophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19559774 chr10:102747161 MRPL43;C10orf2 -0.42 -6.05 -0.31 3.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg00990874 chr7:1149470 C7orf50 -0.6 -7.77 -0.39 9.8e-14 Bronchopulmonary dysplasia; LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg01125463 chr6:42946178 PEX6 0.36 6.03 0.31 4.24e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11890956 chr21:40555474 PSMG1 -0.75 -11.5 -0.53 5.35e-26 Menarche (age at onset); LUSC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg13072238 chr3:49761600 GMPPB -0.74 -9.17 -0.45 5.02e-18 Menarche (age at onset); LUSC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.75 0.35 6.47e-11 Tonsillectomy; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.88 13.49 0.59 2.11e-33 Alzheimer's disease; LUSC cis rs1801251 0.778 rs778338 chr2:233740227 A/G cg08000102 chr2:233561755 GIGYF2 -0.5 -7.77 -0.39 9.6e-14 Coronary artery disease; LUSC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 10.17 0.49 2.37e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg05552183 chr6:42928497 GNMT 0.48 8.18 0.41 6.03e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3771570 1.000 rs56383420 chr2:242219281 A/G cg21155796 chr2:242212141 HDLBP 0.67 7.46 0.38 7.42e-13 Prostate cancer; LUSC trans rs2524005 1.000 rs2524005 chr6:29899677 C/T cg01620082 chr3:125678407 NA -0.51 -7.82 -0.39 7.07e-14 Bipolar disorder and schizophrenia; LUSC cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg18402987 chr7:1209562 NA 0.48 6.12 0.32 2.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7824557 0.527 rs4631425 chr8:11239054 C/T cg08975724 chr8:8085496 FLJ10661 -0.4 -6.01 -0.31 4.99e-9 Retinal vascular caliber; LUSC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.12 0.45 7.37e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs5758659 0.652 rs4822084 chr22:42435868 A/G cg04733989 chr22:42467013 NAGA -0.42 -7.2 -0.37 4.09e-12 Cognitive function; LUSC cis rs1865760 0.534 rs2032444 chr6:26046744 T/G cg16482183 chr6:26056742 HIST1H1C 0.64 8.88 0.44 4.06e-17 Height; LUSC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg02591199 chr4:113066609 C4orf32 0.37 6.02 0.31 4.69e-9 Metabolite levels (Pyroglutamine); LUSC cis rs10779751 0.770 rs1148480 chr1:11172006 A/G cg08854313 chr1:11322531 MTOR 0.84 13.76 0.6 1.87e-34 Body mass index; LUSC cis rs1577917 0.771 rs9362230 chr6:86305013 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.67 -0.43 1.93e-16 Response to antipsychotic treatment; LUSC cis rs3096299 0.685 rs4785568 chr16:89553707 A/G cg08392591 chr16:89556376 ANKRD11 0.47 7.24 0.37 3.16e-12 Multiple myeloma (IgH translocation); LUSC cis rs1451375 0.669 rs4469404 chr7:50647062 C/T cg18232548 chr7:50535776 DDC -0.5 -7.58 -0.38 3.49e-13 Malaria; LUSC cis rs9462027 0.588 rs13215181 chr6:34759881 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.92 -0.31 7.82e-9 Systemic lupus erythematosus; LUSC cis rs34779708 0.966 rs4934725 chr10:35398236 T/C cg04310649 chr10:35416472 CREM -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1577917 0.958 rs2324840 chr6:86557620 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC trans rs7786808 0.778 rs34212455 chr7:158224490 C/T cg02030672 chr11:45687055 CHST1 0.45 6.75 0.35 6.61e-11 Obesity-related traits; LUSC cis rs2486288 0.656 rs11629858 chr15:45547114 T/C cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.73 -0.39 1.31e-13 Glomerular filtration rate; LUSC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.86e-14 Melanoma; LUSC cis rs4073582 0.595 rs801731 chr11:65938446 G/C cg14036092 chr11:66035641 RAB1B 0.4 5.71 0.3 2.51e-8 Gout; LUSC cis rs12760731 0.517 rs11587387 chr1:178229950 C/T cg00404053 chr1:178313656 RASAL2 0.67 6.92 0.35 2.33e-11 Obesity-related traits; LUSC cis rs8016982 0.657 rs8021125 chr14:81704787 C/T cg01989461 chr14:81687754 GTF2A1 -0.68 -11.7 -0.54 9.92e-27 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11309891 chr11:73388802 RAB6A 0.5 6.49 0.33 3.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs7106204 0.514 rs2099890 chr11:24255948 C/T ch.11.24196551F chr11:24239977 NA 0.93 10.34 0.49 6.32e-22 Response to Homoharringtonine (cytotoxicity); LUSC cis rs3784262 1.000 rs1372368 chr15:58297363 C/T cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.93 -0.31 7.51e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs4631830 0.720 rs2611475 chr10:51503178 G/A cg16070123 chr10:51489643 NA -0.56 -9.31 -0.45 1.72e-18 Prostate-specific antigen levels; LUSC trans rs961253 0.556 rs6038446 chr20:6331883 G/A cg21095983 chr6:86352623 SYNCRIP 0.45 6.79 0.35 5.12e-11 Colorectal cancer; LUSC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.57 -8.43 -0.42 1.06e-15 Alzheimer's disease; LUSC cis rs870825 0.616 rs2130394 chr4:185642577 C/A cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs35883536 0.647 rs1995142 chr1:101041174 G/A cg09408571 chr1:101003634 GPR88 0.29 5.67 0.3 3.12e-8 Monocyte count; LUSC cis rs9473147 0.571 rs9369717 chr6:47554468 T/G cg12968598 chr6:47444699 CD2AP 0.52 7.98 0.4 2.29e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs12421382 0.616 rs2357795 chr11:109381135 C/T cg16359550 chr11:109292809 C11orf87 0.36 6.11 0.32 2.76e-9 Schizophrenia; LUSC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg16339924 chr4:17578868 LAP3 0.51 7.77 0.39 1.01e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg08048268 chr3:133502702 NA 0.35 6.41 0.33 4.94e-10 Iron status biomarkers; LUSC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg02825527 chr7:2087843 MAD1L1 -0.51 -5.73 -0.3 2.2e-8 Neuroticism; LUSC cis rs4243830 0.510 rs7518459 chr1:6596678 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -10.3 -0.49 8.86e-22 Body mass index; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg08888203 chr3:10149979 C3orf24 0.59 8.11 0.41 9.88e-15 Alzheimer's disease; LUSC cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs9369695 0.883 rs9473128 chr6:47505010 C/T cg12968598 chr6:47444699 CD2AP 0.53 8.07 0.4 1.3e-14 Reticulocyte count; LUSC trans rs8050260 0.500 rs4783650 chr16:68558528 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.55 -6.74 -0.35 6.86e-11 Plateletcrit; LUSC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg02782426 chr3:40428986 ENTPD3 -0.33 -6.49 -0.33 3.13e-10 Renal cell carcinoma; LUSC cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg17366294 chr4:99064904 C4orf37 0.61 10.92 0.51 6.22e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.549 rs11698185 chr20:25181998 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.64 11.81 0.54 4.02e-27 Liver enzyme levels (alkaline phosphatase); LUSC cis rs72781680 0.898 rs12620558 chr2:23936022 G/A cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.48e-12 Lymphocyte counts; LUSC cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg26597838 chr10:835615 NA 0.95 12.63 0.57 3.77e-30 Eosinophil percentage of granulocytes; LUSC cis rs2050392 0.517 rs160018 chr10:30772703 T/C cg18806716 chr10:30721971 MAP3K8 -0.56 -8.64 -0.43 2.33e-16 Inflammatory bowel disease; LUSC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg02187348 chr16:89574699 SPG7 0.58 9.23 0.45 3.18e-18 Multiple myeloma (IgH translocation); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24443054 chr6:157802504 ZDHHC14 0.44 6.04 0.31 4.22e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7100689 0.646 rs9420370 chr10:82073248 C/T cg01528321 chr10:82214614 TSPAN14 0.82 12.47 0.56 1.41e-29 Post bronchodilator FEV1; LUSC cis rs7592578 0.882 rs61117285 chr2:191468986 G/C cg11845111 chr2:191398756 TMEM194B -0.86 -11.5 -0.53 5.35e-26 Diastolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05971912 chr6:150185499 LRP11 -0.44 -6.7 -0.34 8.82e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg02999463 chr8:37707322 BRF2 0.4 6.15 0.32 2.24e-9 Schizophrenia; LUSC cis rs9811920 0.535 rs704571 chr3:99481946 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.31 -5.85 -0.31 1.15e-8 Axial length; LUSC cis rs3858526 0.834 rs10838993 chr11:5979221 T/C cg25319279 chr11:5960081 NA -0.45 -6.27 -0.32 1.15e-9 DNA methylation (variation); LUSC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg15445000 chr17:37608096 MED1 0.39 6.68 0.34 9.76e-11 Glomerular filtration rate (creatinine); LUSC cis rs9527 0.590 rs1475642 chr10:104546183 C/T cg04362960 chr10:104952993 NT5C2 -0.6 -8.23 -0.41 4.2e-15 Arsenic metabolism; LUSC cis rs796364 0.806 rs203767 chr2:200902411 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -8.3 -0.41 2.64e-15 Schizophrenia; LUSC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg24642439 chr20:33292090 TP53INP2 0.62 9.87 0.48 2.59e-20 Coronary artery disease; LUSC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg12639453 chr1:2035780 PRKCZ 0.29 6.15 0.32 2.27e-9 Height; LUSC cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg17376030 chr22:41985996 PMM1 -0.47 -5.91 -0.31 8.61e-9 Vitiligo; LUSC cis rs1908814 0.516 rs4840597 chr8:11796068 A/C cg21775007 chr8:11205619 TDH 0.47 6.67 0.34 1.05e-10 Neuroticism; LUSC cis rs5771069 0.669 rs137879 chr22:50457041 C/T cg27068297 chr22:50451975 IL17REL 0.38 7.96 0.4 2.71e-14 Ulcerative colitis; LUSC cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg09626299 chr10:82213104 TSPAN14 -0.21 -5.97 -0.31 6.12e-9 Post bronchodilator FEV1; LUSC cis rs9329289 0.590 rs11251295 chr10:2563183 C/T cg15501526 chr10:2543763 NA 0.58 9.62 0.47 1.7e-19 Age-related hearing impairment; LUSC trans rs2243480 0.522 rs1638736 chr7:66092308 A/T cg10756647 chr7:56101905 PSPH 0.88 6.12 0.32 2.65e-9 Diabetic kidney disease; LUSC cis rs427941 0.703 rs201456 chr7:101741059 C/G cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg21132104 chr15:45694354 SPATA5L1 0.56 7.65 0.39 2.19e-13 Homoarginine levels; LUSC cis rs10276303 0.519 rs6947525 chr7:3396065 C/A cg21248987 chr7:3385318 SDK1 -0.39 -6.61 -0.34 1.53e-10 Dupuytren's disease; LUSC cis rs1559088 0.847 rs6510348 chr19:33601946 G/A cg17764715 chr19:33622953 WDR88 0.6 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6121246 0.529 rs6060134 chr20:30176794 A/G cg18721089 chr20:30220636 NA -0.39 -6.15 -0.32 2.2e-9 Mean corpuscular hemoglobin; LUSC cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg02380750 chr20:61661411 NA 0.35 6.08 0.32 3.23e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9303401 0.704 rs7359501 chr17:56641200 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.49 7.8 0.39 7.99e-14 Cognitive test performance; LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg18538332 chr22:24372958 LOC391322 0.43 6.24 0.32 1.3e-9 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs7264396 0.690 rs2425183 chr20:34450621 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -8.27 -0.41 3.33e-15 Total cholesterol levels; LUSC cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg13010199 chr12:38710504 ALG10B -0.5 -7.7 -0.39 1.55e-13 Morning vs. evening chronotype; LUSC cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg00071950 chr4:10020882 SLC2A9 0.58 9.69 0.47 9.66e-20 Bone mineral density; LUSC cis rs9311676 0.632 rs11130646 chr3:58447013 C/G cg26110898 chr3:58419937 PDHB 0.41 6.78 0.35 5.63e-11 Systemic lupus erythematosus; LUSC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg04546413 chr19:29218101 NA 0.71 11.98 0.55 9.36e-28 Methadone dose in opioid dependence; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg05025164 chr4:1340916 KIAA1530 0.43 6.47 0.33 3.5e-10 Obesity-related traits; LUSC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg27165867 chr14:105738592 BRF1 -0.53 -7.84 -0.39 6.15e-14 Platelet count; LUSC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg11189052 chr15:85197271 WDR73 -0.66 -10.26 -0.49 1.2e-21 P wave terminal force; LUSC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.01 0.36 1.29e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg18350739 chr11:68623251 NA -0.37 -6.62 -0.34 1.42e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg24578937 chr1:2090814 PRKCZ -0.45 -10.07 -0.48 5.46e-21 Height; LUSC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg00933542 chr6:150070202 PCMT1 0.32 6.7 0.34 8.68e-11 Lung cancer; LUSC cis rs9323205 0.723 rs12587352 chr14:51739441 T/C cg23942311 chr14:51606299 NA -0.41 -7.84 -0.39 5.93e-14 Cancer; LUSC cis rs2235544 0.554 rs605272 chr1:54467026 T/A cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC trans rs4718428 0.705 rs4717331 chr7:66378886 C/T cg18876405 chr7:65276391 NA 0.5 6.95 0.36 1.97e-11 Corneal structure; LUSC cis rs16866061 1.000 rs3768886 chr2:225450161 G/C cg12698349 chr2:225449008 CUL3 0.87 14.46 0.62 3.8e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg00149659 chr3:10157352 C3orf10 -0.95 -14.42 -0.62 5.6e-37 Alzheimer's disease; LUSC cis rs13191362 0.507 rs7772787 chr6:163190981 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.62 9.57 0.46 2.54e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg12311346 chr5:56204834 C5orf35 -0.94 -13.68 -0.6 3.9e-34 Initial pursuit acceleration; LUSC cis rs7188861 0.768 rs497184 chr16:11389589 G/A cg00044050 chr16:11439710 C16orf75 0.56 6.25 0.32 1.27e-9 HDL cholesterol; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12454419 chr4:77135195 SCARB2 -0.54 -6.35 -0.33 7e-10 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.52 -0.34 2.58e-10 Lung cancer; LUSC cis rs9517313 0.565 rs9556978 chr13:99234648 G/A cg20487152 chr13:99095054 FARP1 -0.42 -7.12 -0.36 6.61e-12 Neuroticism; LUSC cis rs1670533 1.000 rs11247972 chr4:1060550 A/G cg02018176 chr4:1364513 KIAA1530 0.43 5.9 0.31 8.71e-9 Recombination rate (females); LUSC cis rs17021463 0.872 rs11097417 chr4:95268071 C/T cg11021082 chr4:95130006 SMARCAD1 -0.37 -7.04 -0.36 1.12e-11 Testicular germ cell tumor; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13696300 chr17:18162128 FLII 0.49 6.48 0.33 3.23e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs2244503 1.000 rs1523452 chr3:64947340 C/T cg08115371 chr11:79115706 ODZ4 -0.45 -6.25 -0.32 1.24e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg05776053 chr2:74358815 NA 0.47 7.6 0.38 3.05e-13 Gestational age at birth (maternal effect); LUSC cis rs7712401 0.658 rs4836203 chr5:122077077 A/T cg19077854 chr5:122220652 SNX24 0.33 7.08 0.36 8.29e-12 Mean platelet volume; LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg16606324 chr3:10149918 C3orf24 0.64 9.21 0.45 3.73e-18 Alzheimer's disease; LUSC trans rs4714291 0.802 rs1923465 chr6:39971376 A/T cg02267698 chr19:7991119 CTXN1 -0.51 -7.59 -0.38 3.28e-13 Strep throat; LUSC cis rs4595586 0.546 rs11169801 chr12:39241429 G/A cg26384229 chr12:38710491 ALG10B 0.78 11.78 0.54 5.03e-27 Morning vs. evening chronotype; LUSC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg04450456 chr4:17643702 FAM184B 0.35 5.81 0.3 1.43e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7937682 0.924 rs10891288 chr11:111552053 G/T cg18187862 chr3:45730750 SACM1L -0.59 -7.62 -0.38 2.69e-13 Primary sclerosing cholangitis; LUSC cis rs1507153 0.851 rs9352610 chr6:79389398 A/G cg05283184 chr6:79620031 NA -0.39 -6.79 -0.35 5.27e-11 Sjögren's syndrome; LUSC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.36 -6.2 -0.32 1.63e-9 Intelligence (multi-trait analysis); LUSC cis rs710216 0.797 rs1770811 chr1:43400547 A/T cg22176566 chr1:43424700 SLC2A1 0.45 5.75 0.3 2.01e-8 Red cell distribution width; LUSC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.84 12.63 0.57 3.83e-30 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg23260525 chr10:116636907 FAM160B1 0.47 10.25 0.49 1.26e-21 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg11058730 chr11:34937778 PDHX;APIP 0.69 11.15 0.52 9.54e-25 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg27165867 chr14:105738592 BRF1 -0.53 -7.74 -0.39 1.16e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg19318889 chr4:1322082 MAEA 0.46 7.38 0.37 1.29e-12 Obesity-related traits; LUSC cis rs734999 0.505 rs10910107 chr1:2539181 C/T cg18932078 chr1:2524107 MMEL1 0.29 6.26 0.32 1.18e-9 Ulcerative colitis; LUSC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg05754148 chr16:3507555 NAT15 0.53 8.04 0.4 1.58e-14 Tuberculosis; LUSC cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg26384229 chr12:38710491 ALG10B 0.88 15.06 0.64 1.82e-39 Bladder cancer; LUSC cis rs894734 0.535 rs2366142 chr12:54323148 T/C cg25024717 chr12:54324583 NA -0.38 -6.63 -0.34 1.34e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs13006833 0.668 rs2664253 chr2:191148558 G/A cg21644426 chr2:191273491 MFSD6 0.45 6.52 0.34 2.66e-10 Urinary metabolites; LUSC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.29 0.37 2.32e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7580658 0.680 rs6710535 chr2:128190960 C/G cg09760422 chr2:128146352 NA 0.28 5.77 0.3 1.83e-8 Protein C levels; LUSC cis rs601339 0.878 rs7956284 chr12:123183017 G/A cg11919336 chr12:123188078 GPR109A 0.42 6.27 0.32 1.12e-9 Adiponectin levels; LUSC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11105298 0.891 rs10858898 chr12:89922111 A/G cg00757033 chr12:89920650 WDR51B 0.59 10.16 0.49 2.54e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12396054 chr3:194354240 TMEM44 -0.41 -5.99 -0.31 5.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs250677 0.522 rs1432798 chr5:148383345 C/G cg18129178 chr5:148520854 ABLIM3 -0.45 -6.81 -0.35 4.52e-11 Breast cancer; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg20264529 chr10:30638039 MTPAP -0.55 -6.14 -0.32 2.33e-9 Height; LUSC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg00149659 chr3:10157352 C3orf10 0.62 8.63 0.43 2.51e-16 Alzheimer's disease; LUSC cis rs2688608 0.836 rs2675668 chr10:75636148 G/A cg23231163 chr10:75533350 FUT11 -0.38 -6.06 -0.31 3.62e-9 Inflammatory bowel disease; LUSC cis rs4363385 0.747 rs4314835 chr1:152984901 C/T cg00922841 chr1:152955080 SPRR1A -0.45 -7.84 -0.39 6.12e-14 Inflammatory skin disease; LUSC cis rs9469578 1.000 rs9469580 chr6:33715837 A/G cg18708504 chr6:33715942 IP6K3 -0.71 -8.96 -0.44 2.39e-17 Phosphorus levels; LUSC cis rs752010 1.000 rs4999015 chr1:42093547 G/A cg06885757 chr1:42089581 HIVEP3 0.46 9.49 0.46 4.56e-19 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Melanoma; LUSC cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg06484146 chr7:12443880 VWDE -0.64 -6.59 -0.34 1.73e-10 Coronary artery disease; LUSC cis rs4285028 0.747 rs1463736 chr3:121400725 G/A cg11130432 chr3:121712080 ILDR1 -0.56 -8.13 -0.41 8.7e-15 Multiple sclerosis; LUSC trans rs9409565 0.826 rs2139189 chr9:97238538 A/G cg05679027 chr9:99775184 HIATL2 -0.43 -6.32 -0.33 8.14e-10 Colorectal cancer (alcohol consumption interaction); LUSC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg27284194 chr4:1044797 NA 0.37 5.99 0.31 5.41e-9 Obesity-related traits; LUSC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg12386194 chr3:101231763 SENP7 0.46 6.73 0.35 7.37e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs8114671 0.562 rs2064454 chr20:33496169 C/T cg24642439 chr20:33292090 TP53INP2 0.43 6.22 0.32 1.51e-9 Height; LUSC cis rs67460515 0.563 rs4521287 chr3:160812752 C/T cg03342759 chr3:160939853 NMD3 -0.45 -5.95 -0.31 6.79e-9 Parkinson's disease; LUSC cis rs2486288 0.539 rs2433601 chr15:45716425 T/C cg14582100 chr15:45693742 SPATA5L1 0.45 8.44 0.42 9.53e-16 Glomerular filtration rate; LUSC cis rs9650315 0.929 rs13282345 chr8:57163708 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.07 0.36 9.07e-12 Height; LUSC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7954584 0.710 rs10840641 chr12:122465831 G/T cg21016266 chr12:122356598 WDR66 0.44 6.36 0.33 6.8e-10 Mean corpuscular volume; LUSC cis rs4363385 0.620 rs4388644 chr1:152983674 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -5.67 -0.3 3.17e-8 Inflammatory skin disease; LUSC cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg00484396 chr16:3507460 NAT15 0.46 6.88 0.35 3e-11 Body mass index (adult); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11927827 chr4:89513619 HERC3 -0.44 -6.54 -0.34 2.35e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10761482 0.813 rs10821734 chr10:62103412 C/T cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs78366141 0.649 rs78114325 chr4:89682189 T/C cg01026744 chr4:89619053 NAP1L5;HERC3 0.95 7.48 0.38 6.54e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs17125944 0.615 rs12590862 chr14:53297008 A/G cg00686598 chr14:53173677 PSMC6 -0.73 -6.61 -0.34 1.52e-10 Alzheimer's disease (late onset); LUSC cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 7.41 0.38 1.02e-12 Rheumatoid arthritis; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg07332563 chr6:291687 DUSP22 -0.7 -11.77 -0.54 5.6e-27 Menopause (age at onset); LUSC cis rs7173743 0.750 rs12903355 chr15:79129145 A/T cg00540400 chr15:79124168 NA 0.35 6.15 0.32 2.17e-9 Coronary artery disease; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg22907277 chr7:1156413 C7orf50 0.68 7.3 0.37 2.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12908161 1.000 rs34570071 chr15:85280212 T/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.73 0.35 7.18e-11 Schizophrenia; LUSC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.54 -0.8 9.72e-77 Height; LUSC cis rs5769765 1.000 rs2295408 chr22:50261051 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.52 -0.34 2.59e-10 Schizophrenia; LUSC cis rs11051970 0.679 rs2651366 chr12:32560431 T/C cg02745156 chr12:32552066 NA 0.38 6.82 0.35 4.37e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7568458 0.846 rs6743030 chr2:85763520 C/T cg02493740 chr2:85810744 VAMP5 -0.37 -6.53 -0.34 2.49e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7267979 0.966 rs2500433 chr20:25296335 A/G cg03522245 chr20:25566470 NINL -0.36 -5.83 -0.3 1.33e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs929354 1.000 rs1182410 chr7:157063837 C/T cg17757837 chr7:157058334 UBE3C -0.9 -14.63 -0.62 8.54e-38 Body mass index; LUSC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg20135002 chr11:47629003 NA -0.48 -7.4 -0.38 1.09e-12 Subjective well-being; LUSC cis rs193541 0.507 rs7726172 chr5:122081200 C/T cg19077854 chr5:122220652 SNX24 0.27 5.77 0.3 1.82e-8 Glucose homeostasis traits; LUSC cis rs9400467 0.528 rs12214380 chr6:111796937 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.35 -6.57 -0.34 1.98e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs2798269 0.966 rs2761914 chr13:22137130 T/A cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.04 -0.31 4.15e-9 PR segment; LUSC cis rs722599 0.715 rs61978928 chr14:75321714 T/C cg06637938 chr14:75390232 RPS6KL1 -0.4 -5.89 -0.31 9.22e-9 IgG glycosylation; LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg14092988 chr3:52407081 DNAH1 0.31 6.12 0.32 2.57e-9 Bipolar disorder; LUSC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg00784671 chr22:46762841 CELSR1 0.41 6.03 0.31 4.38e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7973719 1.000 rs7973719 chr12:7334813 C/T cg07052231 chr12:7363540 PEX5 0.51 8.82 0.43 6.3e-17 IgG glycosylation; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg15790184 chr11:494944 RNH1 0.58 6.26 0.32 1.18e-9 Body mass index; LUSC cis rs4953076 0.573 rs2053456 chr2:44448632 G/A cg04920474 chr2:44395004 PPM1B 0.63 8.2 0.41 5.37e-15 Height; LUSC cis rs10931896 0.531 rs295117 chr2:201146828 C/T cg23649088 chr2:200775458 C2orf69 0.45 7.0 0.36 1.38e-11 Systolic blood pressure; LUSC cis rs10089 1.000 rs4835943 chr5:127457569 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.67 0.54 1.25e-26 Ileal carcinoids; LUSC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg11890956 chr21:40555474 PSMG1 1.03 20.16 0.74 1.09e-59 Cognitive function; LUSC cis rs3008870 0.792 rs72673729 chr1:67441673 T/TG cg08660285 chr1:67390436 MIER1;WDR78 -0.94 -14.99 -0.63 3.36e-39 Lymphocyte percentage of white cells; LUSC trans rs800082 0.668 rs7643301 chr3:144293612 G/A cg24215973 chr2:240111563 HDAC4 -0.61 -9.81 -0.47 3.99e-20 Smoking behavior; LUSC cis rs61931739 0.534 rs2636082 chr12:34061848 T/A cg06521331 chr12:34319734 NA -0.52 -8.45 -0.42 8.96e-16 Morning vs. evening chronotype; LUSC cis rs977987 0.737 rs8046697 chr16:75442144 T/C cg03315344 chr16:75512273 CHST6 0.49 8.99 0.44 1.91e-17 Dupuytren's disease; LUSC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg22638593 chr5:131593259 PDLIM4 0.37 5.65 0.3 3.52e-8 Breast cancer; LUSC cis rs7172677 1.000 rs1021382 chr15:75417398 A/G cg14664628 chr15:75095509 CSK -0.45 -5.84 -0.3 1.27e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 8.22e-43 Menopause (age at onset); LUSC cis rs8114671 0.539 rs2064453 chr20:33460810 T/C cg24642439 chr20:33292090 TP53INP2 0.42 5.95 0.31 6.7e-9 Height; LUSC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg11764359 chr7:65958608 NA 0.49 6.16 0.32 2.14e-9 Aortic root size; LUSC cis rs1348850 0.914 rs10194648 chr2:178337031 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.05 0.4 1.5e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg20783262 chr1:68152310 GADD45A 0.48 6.06 0.31 3.75e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3857536 0.740 rs9354391 chr6:66890183 C/T cg07460842 chr6:66804631 NA 0.46 6.46 0.33 3.81e-10 Blood trace element (Cu levels); LUSC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg00339695 chr16:24857497 SLC5A11 -0.36 -5.69 -0.3 2.85e-8 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.765 rs12612688 chr2:99613091 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.03 -0.4 1.65e-14 Chronic sinus infection; LUSC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg10523679 chr1:76189770 ACADM 0.91 14.58 0.62 1.3e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.15 0.32 2.24e-9 Personality dimensions; LUSC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg19046167 chr17:80928561 B3GNTL1 -0.46 -6.89 -0.35 2.84e-11 Breast cancer; LUSC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.88e-18 Lung cancer; LUSC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg08027265 chr7:2291960 NA -0.34 -5.77 -0.3 1.82e-8 Schizophrenia; LUSC cis rs62400317 0.859 rs72869127 chr6:45071712 T/C cg18551225 chr6:44695536 NA -0.42 -6.84 -0.35 3.83e-11 Total body bone mineral density; LUSC trans rs1997103 1.000 rs2331067 chr7:55408232 A/T cg20935933 chr6:143382018 AIG1 0.51 7.47 0.38 6.96e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg11530693 chr1:120165357 ZNF697 0.69 10.79 0.51 1.79e-23 Systemic lupus erythematosus; LUSC trans rs66887589 0.592 rs2175383 chr4:120215836 C/A cg25214090 chr10:38739885 LOC399744 0.39 6.12 0.32 2.66e-9 Diastolic blood pressure; LUSC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs1008375 1.000 rs1008374 chr4:17683219 G/A cg16339924 chr4:17578868 LAP3 0.52 7.79 0.39 8.73e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7647973 0.769 rs7434187 chr3:49032967 C/T cg07636037 chr3:49044803 WDR6 0.9 11.52 0.53 4.58e-26 Menarche (age at onset); LUSC cis rs1348850 0.958 rs1545364 chr2:178462882 G/T cg22681709 chr2:178499509 PDE11A -0.47 -8.56 -0.42 4.3e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs96067 0.805 rs4653162 chr1:36613704 G/T cg24686825 chr1:36642396 MAP7D1 0.43 5.81 0.3 1.46e-8 Corneal structure; LUSC cis rs1178968 0.748 rs10271751 chr7:72752062 T/C cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.84e-13 Triglyceride levels; LUSC cis rs4363385 0.818 rs532743 chr1:153011758 T/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs61931739 0.500 rs11053140 chr12:34316122 T/C cg06521331 chr12:34319734 NA -0.48 -8.04 -0.4 1.53e-14 Morning vs. evening chronotype; LUSC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg02269571 chr22:50332266 NA 0.59 8.67 0.43 1.85e-16 Schizophrenia; LUSC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg09555818 chr19:45449301 APOC2 0.43 8.31 0.41 2.41e-15 Blood protein levels; LUSC cis rs2073300 0.609 rs56094936 chr20:23401586 G/A cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg18099408 chr3:52552593 STAB1 -0.41 -7.06 -0.36 9.55e-12 Bipolar disorder; LUSC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg08499158 chr17:42289980 UBTF -0.47 -7.92 -0.4 3.44e-14 Total body bone mineral density; LUSC cis rs6845621 0.745 rs4697168 chr4:18865249 G/T cg12196642 chr4:18937545 NA -0.32 -5.91 -0.31 8.59e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2439831 0.867 rs2447208 chr15:43933895 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.9 9.67 0.47 1.13e-19 Lung cancer in ever smokers; LUSC cis rs9329221 0.905 rs13254263 chr8:10255181 A/G cg27411982 chr8:10470053 RP1L1 -0.51 -8.08 -0.4 1.2e-14 Neuroticism; LUSC cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B -0.51 -8.49 -0.42 6.92e-16 IgG glycosylation; LUSC trans rs12887734 0.546 rs66676135 chr14:104271504 G/A cg16487237 chr3:137487248 NA 0.37 5.97 0.31 5.92e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs13256369 0.802 rs12153 chr8:8560909 G/C cg18904891 chr8:8559673 CLDN23 0.61 8.18 0.41 5.89e-15 Obesity-related traits; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg16393715 chr7:1948819 MAD1L1 0.38 6.43 0.33 4.36e-10 Bipolar disorder and schizophrenia; LUSC cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg02175503 chr12:58329896 NA 0.66 10.82 0.51 1.33e-23 Intelligence (multi-trait analysis); LUSC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.47 -6.27 -0.32 1.13e-9 Tonsillectomy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22807378 chr6:170151601 TCTE3;C6orf70 -0.41 -6.21 -0.32 1.53e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg02221750 chr19:17393354 ANKLE1 -0.9 -14.05 -0.61 1.47e-35 Systemic lupus erythematosus; LUSC cis rs9549367 0.789 rs3764125 chr13:113897648 A/G cg18105134 chr13:113819100 PROZ 0.68 9.66 0.47 1.24e-19 Platelet distribution width; LUSC cis rs10782582 0.593 rs12126155 chr1:76131555 C/G cg03433033 chr1:76189801 ACADM -0.44 -6.56 -0.34 2.02e-10 Daytime sleep phenotypes; LUSC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.58 5.77 0.3 1.85e-8 Cerebrospinal P-tau181p levels; LUSC cis rs9646944 0.501 rs13030675 chr2:103091618 C/A cg20060108 chr2:102954350 IL1RL1 0.47 6.25 0.32 1.24e-9 Blood protein levels; LUSC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18099408 chr3:52552593 STAB1 -0.38 -6.54 -0.34 2.36e-10 Bipolar disorder; LUSC cis rs8017423 0.536 rs11625794 chr14:90811229 C/T cg04374321 chr14:90722782 PSMC1 0.47 7.11 0.36 7.08e-12 Mortality in heart failure; LUSC cis rs1983170 0.808 rs4658229 chr1:92019171 G/A cg25838465 chr1:92012736 NA 0.42 5.86 0.31 1.09e-8 Eosinophil percentage of white cells; LUSC cis rs9457247 0.871 rs1811121 chr6:167403539 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC trans rs3960554 1.000 rs2097947 chr7:75836382 A/T cg19862616 chr7:65841803 NCRNA00174 0.87 10.19 0.49 2.13e-21 Eotaxin levels; LUSC cis rs6500395 1.000 rs9933237 chr16:48676562 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.86e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9318086 0.935 rs9652080 chr13:24435426 A/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.4 -6.14 -0.32 2.3e-9 Myopia (pathological); LUSC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21659725 chr3:3221576 CRBN -0.89 -18.74 -0.72 4.54e-54 Intelligence (multi-trait analysis); LUSC cis rs10791097 0.694 rs1893018 chr11:130756632 T/C cg12179176 chr11:130786555 SNX19 0.84 14.41 0.62 5.79e-37 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC trans rs61931739 0.635 rs1486883 chr12:33908740 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.7 0.39 1.6e-13 Morning vs. evening chronotype; LUSC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg08564027 chr20:61660810 NA 0.9 17.26 0.69 3.72e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.908 rs9995234 chr4:120321827 A/G cg09307838 chr4:120376055 NA 0.76 10.44 0.5 2.84e-22 Corneal astigmatism; LUSC cis rs6598955 0.671 rs12142535 chr1:26589698 T/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs9581857 0.547 rs9579095 chr13:28082555 C/T cg22138327 chr13:27999177 GTF3A 0.69 7.15 0.36 5.43e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs12541635 0.677 rs62527405 chr8:107058109 G/C cg10147462 chr8:107024639 NA 0.66 13.77 0.6 1.77e-34 Age of smoking initiation; LUSC cis rs2143950 0.512 rs62625038 chr14:35517017 A/G cg16230307 chr14:35515116 FAM177A1 -0.42 -5.8 -0.3 1.5e-8 Atopic dermatitis; LUSC cis rs4851254 0.584 rs56935201 chr2:100637788 G/A cg22139774 chr2:100720529 AFF3 -0.44 -5.65 -0.3 3.39e-8 Intelligence (multi-trait analysis); LUSC cis rs10193935 0.901 rs1044562 chr2:42516884 C/G cg27598129 chr2:42591480 NA -0.62 -8.55 -0.42 4.38e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg04518342 chr5:131593106 PDLIM4 0.42 7.36 0.37 1.41e-12 Breast cancer; LUSC cis rs7084402 1.000 rs12259315 chr10:60266152 T/C cg07615347 chr10:60278583 BICC1 -0.35 -5.76 -0.3 1.95e-8 Refractive error; LUSC cis rs7772486 0.846 rs2748496 chr6:146321829 T/A cg05347473 chr6:146136440 FBXO30 0.51 8.45 0.42 9.03e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.9 0.44 3.72e-17 Menopause (age at onset); LUSC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg12310025 chr6:25882481 NA -0.42 -7.39 -0.37 1.21e-12 Height; LUSC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg20684491 chr1:25596433 NA 0.37 5.67 0.3 3.08e-8 Erythrocyte sedimentation rate; LUSC cis rs4499344 0.633 rs259256 chr19:33151802 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.77 11.63 0.54 1.81e-26 Mean platelet volume; LUSC cis rs1507153 0.775 rs9343780 chr6:79355335 T/C cg05283184 chr6:79620031 NA -0.42 -7.29 -0.37 2.29e-12 Sjögren's syndrome; LUSC cis rs1881797 0.527 rs77059530 chr1:247648916 G/A cg14830002 chr1:247616686 OR2B11 0.65 7.41 0.38 1.03e-12 Acute lymphoblastic leukemia (childhood); LUSC trans rs9291683 0.507 rs6849273 chr4:10021595 C/T cg26043149 chr18:55253948 FECH 0.52 7.81 0.39 7.46e-14 Bone mineral density; LUSC cis rs3806843 0.608 rs246042 chr5:140330967 G/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7659604 0.521 rs4833235 chr4:122695136 C/A cg20573242 chr4:122745356 CCNA2 -0.44 -6.41 -0.33 5.1e-10 Type 2 diabetes; LUSC cis rs11031096 0.502 rs4910875 chr11:4047855 C/G cg08557956 chr11:4115526 RRM1 -0.48 -6.26 -0.32 1.2e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg17385448 chr1:15911702 AGMAT 0.37 6.23 0.32 1.41e-9 Systolic blood pressure; LUSC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg04478727 chr12:58166393 METTL1;FAM119B 0.54 7.22 0.37 3.6e-12 Multiple sclerosis; LUSC cis rs7954584 0.616 rs10743186 chr12:122356436 C/T cg10207240 chr12:122356781 WDR66 0.44 6.16 0.32 2.05e-9 Mean corpuscular volume; LUSC cis rs9905704 0.671 rs28709536 chr17:57008912 C/A cg12560992 chr17:57184187 TRIM37 0.58 9.32 0.45 1.65e-18 Testicular germ cell tumor; LUSC cis rs7220711 0.934 rs8068071 chr17:41782779 C/T cg26893861 chr17:41843967 DUSP3 -0.39 -5.65 -0.3 3.49e-8 Bone mineral density (spine);Bone mineral density (hip); LUSC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg18402987 chr7:1209562 NA 0.43 5.69 0.3 2.73e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10779751 0.649 rs1318348 chr1:11130418 A/G cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.83 -0.43 6.22e-17 Axial length; LUSC cis rs950776 0.518 rs952216 chr15:78819202 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.41 0.33 4.82e-10 Sudden cardiac arrest; LUSC cis rs7799006 0.634 rs34502289 chr7:2311266 G/A cg08027265 chr7:2291960 NA -0.62 -11.11 -0.52 1.32e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs936229 0.768 rs936226 chr15:75069282 C/T cg10253484 chr15:75165896 SCAMP2 -0.52 -6.73 -0.35 7.39e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg06022373 chr22:39101656 GTPBP1 -0.8 -13.46 -0.59 2.71e-33 Menopause (age at onset); LUSC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg06505273 chr16:24850292 NA 0.39 5.69 0.3 2.8e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg03929089 chr4:120376271 NA -0.94 -16.46 -0.67 5.66e-45 Height; LUSC cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg24692254 chr21:30365293 RNF160 0.83 15.26 0.64 2.99e-40 Dental caries; LUSC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg04352962 chr1:209979756 IRF6 0.5 6.74 0.35 7.02e-11 Cleft lip with or without cleft palate; LUSC cis rs11122272 0.735 rs2808611 chr1:231548480 A/G cg06096015 chr1:231504339 EGLN1 -0.53 -9.19 -0.45 4.44e-18 Hemoglobin concentration; LUSC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg20295408 chr7:1910781 MAD1L1 -0.44 -6.42 -0.33 4.6e-10 Schizophrenia; LUSC cis rs2857891 0.695 rs2248438 chr11:6985062 G/C cg04053776 chr11:6947353 ZNF215 0.41 6.06 0.31 3.65e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs7766436 0.885 rs12111199 chr6:22578106 C/T cg13666174 chr6:22585274 NA -0.41 -5.73 -0.3 2.29e-8 Coronary artery disease; LUSC cis rs7215564 0.908 rs35884143 chr17:78656043 A/G cg09596252 chr17:78655493 RPTOR 0.55 5.92 0.31 7.92e-9 Myopia (pathological); LUSC cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.12 -0.45 7.15e-18 Monocyte percentage of white cells; LUSC cis rs17608059 1.000 rs17608059 chr17:13910549 C/T cg27005118 chr17:13972210 COX10 -0.32 -6.02 -0.31 4.59e-9 Temperament; LUSC cis rs6901250 0.851 rs2175622 chr6:117149667 T/A cg12892004 chr6:117198278 RFX6 0.44 8.18 0.41 6.14e-15 C-reactive protein levels; LUSC cis rs9341808 0.519 rs3805878 chr6:81013855 A/G cg08355045 chr6:80787529 NA 0.39 6.84 0.35 3.8e-11 Sitting height ratio; LUSC cis rs3087591 0.659 rs8065496 chr17:29720140 T/C cg24425628 chr17:29625626 OMG;NF1 0.46 6.77 0.35 5.98e-11 Hip circumference; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23456826 chr14:24912049 SDR39U1 0.39 6.32 0.33 8.59e-10 Triglycerides; LUSC cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.31 -0.37 1.96e-12 Menopause (age at onset); LUSC cis rs7312933 0.669 rs7974476 chr12:42542484 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.68 0.34 9.99e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs55665837 1.000 rs12276938 chr11:14463488 C/G cg19336497 chr11:14380999 RRAS2 -0.38 -7.54 -0.38 4.43e-13 Vitamin D levels; LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs6964587 0.626 rs9008 chr7:91502407 C/G cg17063962 chr7:91808500 NA -0.56 -9.1 -0.45 8.07e-18 Breast cancer; LUSC cis rs4919687 0.679 rs12762176 chr10:104499232 A/T cg05855489 chr10:104503620 C10orf26 0.72 11.11 0.52 1.28e-24 Colorectal cancer; LUSC cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg04455712 chr21:45112962 RRP1B 0.46 8.88 0.44 4.26e-17 Mean corpuscular volume; LUSC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg06618935 chr21:46677482 NA -0.39 -7.46 -0.38 7.69e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6723226 0.881 rs10181198 chr2:32686582 A/G cg02381751 chr2:32503542 YIPF4 0.63 9.45 0.46 6.01e-19 Intelligence (multi-trait analysis); LUSC cis rs1005224 0.926 rs7143743 chr14:76127805 G/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.68 -9.36 -0.46 1.18e-18 Large artery stroke; LUSC cis rs8077889 0.917 rs4793038 chr17:41916761 A/T cg26893861 chr17:41843967 DUSP3 0.91 14.58 0.62 1.3e-37 Triglycerides; LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.73 0.65 4.3e-42 Platelet count; LUSC cis rs12579753 0.956 rs11115039 chr12:82217338 A/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.82 -0.3 1.34e-8 Resting heart rate; LUSC cis rs699371 0.507 rs10149787 chr14:74925452 A/C cg16374328 chr14:74960395 NPC2;ISCA2 -0.36 -5.8 -0.3 1.54e-8 Height; LUSC cis rs17824933 1.000 rs929230 chr11:60760971 C/T cg16817237 chr11:60793675 NA 0.39 6.19 0.32 1.73e-9 Multiple sclerosis; LUSC trans rs1941687 0.797 rs12963024 chr18:31389547 A/G cg27147174 chr7:100797783 AP1S1 -0.47 -6.84 -0.35 3.87e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg15839431 chr19:19639596 YJEFN3 -0.58 -6.62 -0.34 1.46e-10 Bipolar disorder; LUSC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg14582100 chr15:45693742 SPATA5L1 0.59 10.77 0.51 2.09e-23 Homoarginine levels; LUSC cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg15839431 chr19:19639596 YJEFN3 -0.63 -7.15 -0.36 5.48e-12 Bipolar disorder; LUSC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg11812906 chr14:75593930 NEK9 -0.63 -10.32 -0.49 7.18e-22 Height; LUSC trans rs7647973 0.626 rs35129566 chr3:49866584 T/G cg21659725 chr3:3221576 CRBN 0.71 8.58 0.42 3.58e-16 Menarche (age at onset); LUSC cis rs73206853 0.563 rs11830452 chr12:111198576 A/T cg12870014 chr12:110450643 ANKRD13A 0.65 6.92 0.35 2.32e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg12463550 chr7:65579703 CRCP 0.44 6.5 0.33 3.01e-10 Aortic root size; LUSC cis rs2439831 1.000 rs2245790 chr15:43744457 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.03 0.44 1.35e-17 Lung cancer in ever smokers; LUSC cis rs2692947 0.644 rs1168970 chr2:96816606 C/T cg23100626 chr2:96804247 ASTL 0.3 7.14 0.36 6.01e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs713587 0.713 rs1982200 chr2:25205427 C/T cg01884057 chr2:25150051 NA -0.38 -8.58 -0.42 3.67e-16 Body mass index in non-asthmatics; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg11905131 chr22:24372483 LOC391322 -0.59 -9.89 -0.48 2.06e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11644478 chr21:40555479 PSMG1 0.95 18.98 0.72 5.3e-55 Cognitive function; LUSC cis rs6815814 0.950 rs5743565 chr4:38805983 T/C cg02016764 chr4:38805732 TLR1 -0.53 -5.74 -0.3 2.16e-8 Breast cancer; LUSC cis rs9534288 0.830 rs1548325 chr13:46635101 A/G cg15192986 chr13:46630673 CPB2 -0.79 -12.65 -0.57 3.06e-30 Blood protein levels; LUSC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg05527609 chr1:210001259 C1orf107 -0.46 -6.96 -0.36 1.78e-11 Monobrow; LUSC cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg14343924 chr8:8086146 FLJ10661 0.43 6.18 0.32 1.86e-9 Mood instability; LUSC cis rs3096299 0.748 rs3102339 chr16:89442711 C/T cg00750074 chr16:89608354 SPG7 -0.45 -7.33 -0.37 1.71e-12 Multiple myeloma (IgH translocation); LUSC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06022373 chr22:39101656 GTPBP1 -0.74 -11.66 -0.54 1.39e-26 Menopause (age at onset); LUSC cis rs9326248 0.520 rs2735183 chr11:117015195 C/T cg11861562 chr11:117069780 TAGLN 0.3 5.72 0.3 2.38e-8 Blood protein levels; LUSC cis rs1577917 0.771 rs9450290 chr6:86233397 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.54 0.42 4.94e-16 Response to antipsychotic treatment; LUSC cis rs9583531 0.689 rs9515273 chr13:111383427 G/C cg24331049 chr13:111365604 ING1 0.63 8.2 0.41 5.4e-15 Coronary artery disease; LUSC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg21285383 chr16:89894308 SPIRE2 -0.3 -5.8 -0.3 1.51e-8 Vitiligo; LUSC cis rs6580649 0.941 rs17122613 chr12:48460016 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg23711669 chr6:146136114 FBXO30 -0.91 -17.02 -0.68 3.26e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.43 -0.46 6.97e-19 Chronic sinus infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06585708 chr5:3602413 NA 0.29 6.03 0.31 4.26e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg04756594 chr16:24857601 SLC5A11 -0.41 -5.65 -0.3 3.41e-8 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg23711669 chr6:146136114 FBXO30 -0.89 -16.79 -0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9905704 0.681 rs887206 chr17:56575084 G/C cg19466818 chr17:56409534 MIR142 0.37 7.05 0.36 1.01e-11 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg04369109 chr6:150039330 LATS1 -0.54 -8.05 -0.4 1.51e-14 Lung cancer; LUSC cis rs10927875 0.597 rs61782184 chr1:16150976 G/A cg21385522 chr1:16154831 NA -1.02 -20.42 -0.75 1.04e-60 Dilated cardiomyopathy; LUSC cis rs208520 0.586 rs208442 chr6:66900618 T/A cg07460842 chr6:66804631 NA -0.79 -11.27 -0.52 3.47e-25 Exhaled nitric oxide output; LUSC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.71 0.47 8.46e-20 Bipolar disorder; LUSC cis rs637571 0.726 rs669371 chr11:65674153 G/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.43 -7.11 -0.36 7.01e-12 Eosinophil percentage of white cells; LUSC cis rs3806843 1.000 rs2337985 chr5:140157861 T/C cg26395211 chr5:140044315 WDR55 -0.38 -5.83 -0.3 1.28e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7524258 0.900 rs7514988 chr1:7271651 C/T cg07173049 chr1:7289937 CAMTA1 0.31 6.51 0.34 2.73e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs6733011 0.578 rs1878585 chr2:99501698 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.84 -0.35 3.69e-11 Bipolar disorder; LUSC cis rs6674970 0.627 rs2864700 chr1:151028929 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.39 -5.65 -0.3 3.35e-8 Childhood ear infection; LUSC cis rs6964587 0.869 rs7810391 chr7:91520227 G/A cg17063962 chr7:91808500 NA -0.53 -8.24 -0.41 4.03e-15 Breast cancer; LUSC cis rs12530845 0.945 rs12540273 chr7:135333854 T/G cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs308403 0.568 rs13146929 chr4:123671151 C/G cg10495464 chr4:123653540 BBS12;LOC729338 0.79 10.2 0.49 1.95e-21 Blood protein levels; LUSC cis rs41271473 0.607 rs10916361 chr1:228859971 A/T cg10167378 chr1:228756711 NA 0.48 6.89 0.35 2.82e-11 Chronic lymphocytic leukemia; LUSC cis rs6541297 0.941 rs2180078 chr1:230280513 T/C cg05784532 chr1:230284198 GALNT2 0.54 8.04 0.4 1.57e-14 Coronary artery disease; LUSC cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg09165964 chr15:75287851 SCAMP5 -0.45 -6.78 -0.35 5.41e-11 Breast cancer; LUSC trans rs12439619 1.000 rs12439619 chr15:82546946 T/G cg04831495 chr15:85060580 GOLGA6L5 -0.54 -8.62 -0.43 2.7e-16 Intelligence (multi-trait analysis); LUSC cis rs11608355 0.515 rs11609921 chr12:109918405 A/G cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg11764359 chr7:65958608 NA -0.78 -12.93 -0.58 2.79e-31 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23564255 chr14:24711932 TINF2 -0.44 -6.82 -0.35 4.3e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4595586 0.525 rs17464772 chr12:39247777 G/A cg26384229 chr12:38710491 ALG10B 0.78 11.72 0.54 8.25e-27 Morning vs. evening chronotype; LUSC trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -13.61 -0.6 7.56e-34 Coronary artery disease; LUSC cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg03647239 chr10:116582469 FAM160B1 0.46 7.35 0.37 1.52e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9308433 0.529 rs10465696 chr1:214499883 G/A cg06198575 chr1:214491504 SMYD2 0.45 6.99 0.36 1.46e-11 IgG glycosylation; LUSC trans rs1949829 1.000 rs1949829 chr7:51537887 C/T cg20941110 chr15:83953819 BNC1 0.55 6.05 0.31 3.85e-9 Wegener's granulomatosis; LUSC cis rs4654899 0.758 rs6694455 chr1:21352185 C/T cg01072550 chr1:21505969 NA -0.54 -8.29 -0.41 2.85e-15 Superior frontal gyrus grey matter volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17450446 chr1:160002111 PIGM 0.4 6.15 0.32 2.27e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8072100 0.713 rs9899859 chr17:45513049 A/G cg08085267 chr17:45401833 C17orf57 -0.51 -7.3 -0.37 2.07e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs9486715 0.838 rs9486275 chr6:96901187 C/T cg06623918 chr6:96969491 KIAA0776 0.93 17.44 0.69 6.92e-49 Headache; LUSC cis rs6840360 0.554 rs6849111 chr4:152708874 T/C cg22705602 chr4:152727874 NA -0.38 -8.16 -0.41 6.96e-15 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.23e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11098499 0.569 rs10023641 chr4:120258410 C/G cg24375607 chr4:120327624 NA 0.72 11.66 0.54 1.38e-26 Corneal astigmatism; LUSC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs6120849 0.754 rs6120804 chr20:33623701 C/A cg24642439 chr20:33292090 TP53INP2 0.61 6.74 0.35 6.84e-11 Protein C levels; LUSC cis rs3087591 0.919 rs2952993 chr17:29539998 G/A cg24425628 chr17:29625626 OMG;NF1 0.6 8.67 0.43 1.91e-16 Hip circumference; LUSC cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg13852791 chr20:30311386 BCL2L1 0.91 12.43 0.56 2.13e-29 Mean corpuscular hemoglobin; LUSC cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg04034577 chr2:241836375 C2orf54 0.49 9.31 0.45 1.75e-18 Urinary metabolites; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.0 0.44 1.77e-17 Prudent dietary pattern; LUSC cis rs483180 0.512 rs594400 chr1:120214275 G/T cg19096424 chr1:120255104 PHGDH -0.46 -6.42 -0.33 4.6e-10 Macular telangiectasia type 2; LUSC cis rs7264396 0.779 rs6087723 chr20:34175783 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.52 7.56 0.38 3.84e-13 Total cholesterol levels; LUSC cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.44e-23 Bladder cancer; LUSC trans rs7647973 0.626 rs11720705 chr3:49753788 A/G cg21659725 chr3:3221576 CRBN -0.65 -7.72 -0.39 1.36e-13 Menarche (age at onset); LUSC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg06671706 chr8:8559999 CLDN23 0.5 6.68 0.34 9.98e-11 Obesity-related traits; LUSC cis rs28655083 0.956 rs8060627 chr16:77077065 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.43 -6.72 -0.35 7.71e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -7.52 -0.38 4.98e-13 Renal function-related traits (BUN); LUSC cis rs9790314 1.000 rs9846756 chr3:160983809 A/C cg03342759 chr3:160939853 NMD3 -0.5 -8.49 -0.42 6.79e-16 Morning vs. evening chronotype; LUSC cis rs3087591 0.708 rs3815154 chr17:29654974 G/A cg24425628 chr17:29625626 OMG;NF1 0.46 6.86 0.35 3.37e-11 Hip circumference; LUSC cis rs6964587 0.655 rs6965864 chr7:91595596 A/G cg17063962 chr7:91808500 NA 0.57 9.61 0.47 1.86e-19 Breast cancer; LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg04234412 chr22:24373322 LOC391322 -0.76 -12.48 -0.56 1.28e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg18876405 chr7:65276391 NA -0.58 -9.25 -0.45 2.75e-18 Aortic root size; LUSC cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg21573476 chr21:45109991 RRP1B 0.39 6.49 0.33 3.07e-10 Mean corpuscular volume; LUSC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg22800045 chr5:56110881 MAP3K1 0.43 5.89 0.31 9.65e-9 Coronary artery disease; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg15790184 chr11:494944 RNH1 0.42 6.4 0.33 5.37e-10 Systemic lupus erythematosus; LUSC cis rs2652834 1.000 rs2729788 chr15:63400378 G/C cg05507819 chr15:63340323 TPM1 0.68 8.21 0.41 4.95e-15 HDL cholesterol; LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg18402987 chr7:1209562 NA 0.73 7.85 0.39 5.87e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6961069 0.837 rs1722505 chr7:80240689 T/C cg04458919 chr7:80252533 CD36 -0.36 -6.63 -0.34 1.32e-10 Platelet count; LUSC cis rs6692729 0.933 rs1046240 chr1:227071525 C/T cg10327440 chr1:227177885 CDC42BPA -0.51 -7.32 -0.37 1.91e-12 Electrodermal activity; LUSC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg18876405 chr7:65276391 NA 0.68 12.02 0.55 6.91e-28 Aortic root size; LUSC cis rs7223966 1.000 rs8075521 chr17:61804954 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.09 0.32 3.17e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4786125 0.639 rs7200754 chr16:6897636 A/G cg03623568 chr16:6915990 A2BP1 0.35 6.31 0.33 8.99e-10 Heart rate variability traits (SDNN); LUSC trans rs9329221 0.537 rs2062332 chr8:9980024 G/A cg06636001 chr8:8085503 FLJ10661 0.48 7.07 0.36 9.18e-12 Neuroticism; LUSC cis rs453301 0.658 rs3855900 chr8:8901921 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.28 -0.45 2.21e-18 Joint mobility (Beighton score); LUSC cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg05347473 chr6:146136440 FBXO30 0.46 7.96 0.4 2.77e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs782590 0.902 rs782601 chr2:55848244 T/C cg18811423 chr2:55921094 PNPT1 0.78 13.25 0.59 1.72e-32 Metabolic syndrome; LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg26338869 chr17:61819248 STRADA 0.42 6.18 0.32 1.88e-9 Prudent dietary pattern; LUSC cis rs4843747 0.641 rs11117353 chr16:88090895 A/G cg17633681 chr16:88106987 BANP 0.47 8.38 0.42 1.51e-15 Menopause (age at onset); LUSC cis rs1997103 0.954 rs6593235 chr7:55410986 A/G cg17469321 chr7:55412551 NA 0.66 10.59 0.5 8.59e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs7824557 0.510 rs4841524 chr8:11243126 C/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.21 -0.32 1.59e-9 Retinal vascular caliber; LUSC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg11764359 chr7:65958608 NA 0.55 7.2 0.37 3.94e-12 Aortic root size; LUSC cis rs12367572 0.620 rs1857925 chr12:45344385 T/C cg04608330 chr12:45269318 NELL2 -0.39 -6.01 -0.31 4.98e-9 Gut microbiome composition (summer); LUSC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg20684491 chr1:25596433 NA 0.39 6.12 0.32 2.61e-9 Erythrocyte sedimentation rate; LUSC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg06238570 chr21:40685208 BRWD1 -0.56 -8.77 -0.43 9.03e-17 Menarche (age at onset); LUSC cis rs897984 0.568 rs11862962 chr16:30909706 C/G cg02466173 chr16:30829666 NA -0.53 -8.56 -0.42 4.15e-16 Dementia with Lewy bodies; LUSC cis rs6840360 0.533 rs13147021 chr4:152722688 A/C cg22705602 chr4:152727874 NA 0.38 7.85 0.39 5.54e-14 Intelligence (multi-trait analysis); LUSC cis rs7903847 0.642 rs7924254 chr10:99120925 C/T cg20016023 chr10:99160130 RRP12 -0.29 -6.2 -0.32 1.7e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs13082711 0.863 rs36055621 chr3:27436797 T/C cg02860705 chr3:27208620 NA 0.46 7.66 0.39 2e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs1493916 1.000 rs11081827 chr18:31390228 C/A cg27147174 chr7:100797783 AP1S1 -0.68 -10.87 -0.51 9.28e-24 Life satisfaction; LUSC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg02569458 chr12:86230093 RASSF9 0.54 8.83 0.44 5.86e-17 Major depressive disorder; LUSC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.5 0.34 2.85e-10 Hip circumference adjusted for BMI; LUSC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg17385448 chr1:15911702 AGMAT -0.38 -6.54 -0.34 2.27e-10 Systolic blood pressure; LUSC cis rs7246657 0.943 rs10420430 chr19:37894194 C/G cg23950597 chr19:37808831 NA -0.64 -7.56 -0.38 3.91e-13 Coronary artery calcification; LUSC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg26513180 chr16:89883248 FANCA 0.9 17.06 0.68 2.16e-47 Vitiligo; LUSC cis rs9322817 0.691 rs2499663 chr6:105300570 A/G cg02098413 chr6:105308735 HACE1 -0.27 -5.84 -0.3 1.25e-8 Thyroid stimulating hormone; LUSC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg17279839 chr7:150038598 RARRES2 -0.44 -6.81 -0.35 4.59e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg23630131 chr7:65973040 NA 0.21 5.81 0.3 1.45e-8 Aortic root size; LUSC cis rs17407555 0.697 rs56079809 chr4:10102736 C/A cg00071950 chr4:10020882 SLC2A9 -0.54 -6.57 -0.34 1.9e-10 Schizophrenia (age at onset); LUSC cis rs9341808 0.556 rs10455370 chr6:81040867 A/G cg08355045 chr6:80787529 NA -0.46 -7.86 -0.4 5.17e-14 Sitting height ratio; LUSC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg25554036 chr4:6271136 WFS1 0.59 12.15 0.55 2.29e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9650315 0.929 rs7829319 chr8:57172232 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.68 0.34 1.01e-10 Height; LUSC cis rs4478137 0.931 rs4057797 chr4:164245053 T/A cg06758707 chr4:164254230 NPY1R 0.63 9.92 0.48 1.7e-20 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg17366294 chr4:99064904 C4orf37 0.59 10.39 0.49 4.12e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs11105298 0.891 rs3741898 chr12:89933763 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.21 -0.37 3.73e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4888262 0.514 rs8048239 chr16:74578317 A/T cg01733217 chr16:74700730 RFWD3 0.74 12.46 0.56 1.53e-29 Testicular germ cell tumor; LUSC cis rs11098499 0.738 rs10026493 chr4:120384194 C/G cg09307838 chr4:120376055 NA 0.77 11.09 0.52 1.49e-24 Corneal astigmatism; LUSC cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.02 0.58 1.28e-31 Chronic sinus infection; LUSC cis rs273573 0.922 rs927224 chr11:30810665 T/C cg06552810 chr11:31128660 NA -0.33 -5.71 -0.3 2.43e-8 Total body bone mineral density; LUSC cis rs10751667 0.666 rs6597966 chr11:950750 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.45 0.33 3.9e-10 Alzheimer's disease (late onset); LUSC cis rs6580649 0.941 rs11612578 chr12:48414798 T/C cg24011408 chr12:48396354 COL2A1 -0.49 -6.73 -0.35 7.51e-11 Lung cancer; LUSC cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg12011299 chr4:100065546 ADH4 0.71 11.07 0.52 1.75e-24 Alcohol dependence; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg12564285 chr5:131593104 PDLIM4 -0.48 -8.3 -0.41 2.59e-15 Blood metabolite levels; LUSC cis rs7819412 1.000 rs7819412 chr8:11045161 A/G cg27411982 chr8:10470053 RP1L1 0.43 6.63 0.34 1.36e-10 Triglycerides; LUSC cis rs7408868 0.611 rs11671336 chr19:15294043 C/T cg14696996 chr19:15285081 NOTCH3 0.64 6.76 0.35 6.09e-11 Pulse pressure; LUSC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg09365446 chr1:150670422 GOLPH3L 0.52 8.07 0.4 1.29e-14 Tonsillectomy; LUSC cis rs12980942 0.872 rs2053086 chr19:41799475 C/T cg25627403 chr19:41769009 HNRNPUL1 -0.61 -6.54 -0.34 2.26e-10 Coronary artery disease; LUSC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.26e-8 Total body bone mineral density; LUSC cis rs4566357 0.615 rs2272202 chr2:227914625 C/T cg11843606 chr2:227700838 RHBDD1 0.53 8.15 0.41 7.43e-15 Coronary artery disease; LUSC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg18302933 chr2:88491318 NA -0.38 -7.54 -0.38 4.57e-13 Response to metformin (IC50); LUSC cis rs1728785 0.748 rs889560 chr16:68605784 A/G cg02972257 chr16:68554789 NA -0.53 -6.6 -0.34 1.64e-10 Ulcerative colitis; LUSC trans rs34421088 0.506 rs4841518 chr8:11145963 G/C cg06636001 chr8:8085503 FLJ10661 0.5 7.39 0.37 1.17e-12 Neuroticism; LUSC cis rs6964587 0.869 rs10278155 chr7:91532456 T/G cg17063962 chr7:91808500 NA -0.52 -8.03 -0.4 1.65e-14 Breast cancer; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg23161317 chr6:28129485 ZNF389 0.44 5.69 0.3 2.71e-8 Parkinson's disease; LUSC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg01416388 chr22:39784598 NA -0.45 -6.95 -0.36 1.91e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs28374715 0.662 rs28382348 chr15:41487934 G/C cg18705301 chr15:41695430 NDUFAF1 -0.86 -15.28 -0.64 2.37e-40 Ulcerative colitis; LUSC cis rs9297145 0.715 rs62473008 chr7:98751541 A/G cg05967295 chr7:98741636 SMURF1 0.99 14.86 0.63 1.1e-38 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg12927641 chr6:109611667 NA 0.4 6.82 0.35 4.25e-11 Reticulocyte fraction of red cells; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs12474201 0.619 rs17821827 chr2:46918682 C/T cg09399716 chr2:46890238 NA -0.43 -8.27 -0.41 3.32e-15 Height; LUSC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg18252515 chr7:66147081 NA 1.23 14.12 0.61 8.1e-36 Diabetic kidney disease; LUSC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg06108461 chr20:60628389 TAF4 -1.01 -17.64 -0.69 1.14e-49 Body mass index; LUSC cis rs9311676 0.656 rs11712213 chr3:58384995 G/A cg13750441 chr3:58318267 PXK 0.35 6.72 0.35 7.86e-11 Systemic lupus erythematosus; LUSC cis rs11098499 0.954 rs2892848 chr4:120381341 C/T cg09307838 chr4:120376055 NA 0.77 11.2 0.52 6.24e-25 Corneal astigmatism; LUSC cis rs2637266 1.000 rs7392737 chr10:78366059 C/T cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.61e-12 Pulmonary function; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg22903657 chr4:1355424 KIAA1530 -0.37 -6.3 -0.33 9.34e-10 Obesity-related traits; LUSC cis rs506338 0.517 rs516117 chr11:64433444 T/C cg19131476 chr11:64387923 NRXN2 0.36 7.81 0.39 7.34e-14 Body mass index;Urate levels; LUSC trans rs61931739 0.500 rs6488211 chr12:34375620 A/T cg26384229 chr12:38710491 ALG10B -0.8 -13.11 -0.58 5.6199999999999995e-32 Morning vs. evening chronotype; LUSC trans rs67133203 1.000 rs67133203 chr12:51426657 A/T cg17484237 chr5:156536107 HAVCR2 0.44 5.97 0.31 6.2e-9 Urinary tract infection frequency; LUSC cis rs2236918 1.000 rs1635512 chr1:242024500 A/G cg17736920 chr1:242011382 EXO1 -0.45 -7.13 -0.36 6.19e-12 Menopause (age at onset); LUSC cis rs4423214 0.840 rs1790339 chr11:71182761 C/A cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs4343996 0.901 rs1112428 chr7:3352512 T/C cg21248987 chr7:3385318 SDK1 -0.36 -6.1 -0.32 2.93e-9 Motion sickness; LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg08736216 chr1:53307985 ZYG11A 0.28 5.74 0.3 2.12e-8 Monocyte count; LUSC cis rs116095464 0.558 rs62346508 chr5:203668 T/C cg22857025 chr5:266934 NA -1.2 -14.11 -0.61 8.51e-36 Breast cancer; LUSC cis rs617219 0.819 rs6889156 chr5:78596919 T/C cg24856658 chr5:78533917 JMY 0.31 5.99 0.31 5.44e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg20573242 chr4:122745356 CCNA2 0.64 9.44 0.46 6.7e-19 Type 2 diabetes; LUSC cis rs4906332 0.782 rs7161305 chr14:104002234 G/A cg04998671 chr14:104000505 TRMT61A -0.58 -7.8 -0.39 7.99e-14 Coronary artery disease; LUSC cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs11209185 0.509 rs9436790 chr1:68447044 G/A cg22082780 chr1:68452167 NA 0.44 7.38 0.37 1.27e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC trans rs4689388 0.890 rs4501291 chr4:6298582 C/T cg17567195 chr5:167378696 ODZ2 -0.4 -6.2 -0.32 1.68e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9395066 0.545 rs12526711 chr6:44883873 C/T cg25276700 chr6:44698697 NA 0.3 6.11 0.32 2.76e-9 Height; LUSC cis rs262150 0.625 rs55974535 chr7:158769145 C/G cg09640425 chr7:158790006 NA 0.47 5.66 0.3 3.32e-8 Facial morphology (factor 20); LUSC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.63 -0.34 1.33e-10 Alzheimer's disease (late onset); LUSC cis rs4499344 0.556 rs865659 chr19:33139967 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.94 13.87 0.6 7.32e-35 Mean platelet volume; LUSC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg00933542 chr6:150070202 PCMT1 0.31 6.51 0.34 2.78e-10 Lung cancer; LUSC cis rs2486288 0.656 rs1706768 chr15:45569443 T/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.99 -0.4 2.22e-14 Glomerular filtration rate; LUSC cis rs4842666 0.915 rs17249754 chr12:90060586 A/G cg00757033 chr12:89920650 WDR51B -0.47 -6.96 -0.36 1.79e-11 Blood pressure; LUSC cis rs7119 0.666 rs2516302 chr15:77879842 C/G cg27398640 chr15:77910606 LINGO1 0.36 8.37 0.42 1.61e-15 Type 2 diabetes; LUSC cis rs4595586 0.545 rs12812762 chr12:39371141 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.87 0.31 1.06e-8 Morning vs. evening chronotype; LUSC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg27494647 chr7:150038898 RARRES2 0.48 7.29 0.37 2.23e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs929354 0.772 rs10228145 chr7:157007337 A/G cg05182265 chr7:156933206 UBE3C -0.61 -10.08 -0.48 4.95e-21 Body mass index; LUSC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg18131467 chr2:239335373 ASB1 1.01 23.44 0.79 1.51e-72 Multiple system atrophy; LUSC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg00677455 chr12:58241039 CTDSP2 0.62 8.65 0.43 2.18e-16 Multiple sclerosis; LUSC cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg13010199 chr12:38710504 ALG10B 0.62 9.48 0.46 4.72e-19 Bladder cancer; LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg02951883 chr7:2050386 MAD1L1 -0.39 -6.57 -0.34 1.98e-10 Bipolar disorder and schizophrenia; LUSC cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg10253484 chr15:75165896 SCAMP2 -0.6 -8.41 -0.42 1.23e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg12483801 chr4:183727862 NA 0.42 5.88 0.31 1e-8 Pediatric autoimmune diseases; LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg05738196 chr6:26577821 NA -0.6 -7.05 -0.36 1e-11 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.730 rs35713471 chr15:72459971 C/A cg16672083 chr15:72433130 SENP8 -0.51 -7.33 -0.37 1.71e-12 Red blood cell count; LUSC trans rs11088226 0.581 rs2016103 chr21:33878030 G/A cg09050820 chr6:167586206 TCP10L2 0.49 7.73 0.39 1.24e-13 Gastritis; LUSC cis rs7824557 0.564 rs2572392 chr8:11235605 T/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.01 -0.31 4.97e-9 Retinal vascular caliber; LUSC cis rs35146811 0.520 rs1015538 chr7:99626035 A/G cg22906224 chr7:99728672 NA -0.56 -8.52 -0.42 5.57e-16 Coronary artery disease; LUSC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg14343924 chr8:8086146 FLJ10661 0.42 5.97 0.31 5.9e-9 Mood instability; LUSC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.59 0.34 1.76e-10 Lung cancer; LUSC cis rs11630290 0.592 rs11634436 chr15:64158394 T/G cg12036633 chr15:63758958 NA 0.53 6.83 0.35 4.13e-11 Iris characteristics; LUSC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg04546413 chr19:29218101 NA 0.72 11.48 0.53 6.21e-26 Methadone dose in opioid dependence; LUSC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg02038168 chr22:39784481 NA -0.43 -6.55 -0.34 2.23e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg05872129 chr22:39784769 NA -0.51 -7.27 -0.37 2.51e-12 IgG glycosylation; LUSC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg15017067 chr4:17643749 FAM184B 0.34 5.76 0.3 1.96e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1348850 1.000 rs1348850 chr2:178418575 A/G cg22681709 chr2:178499509 PDE11A -0.47 -8.61 -0.43 3.03e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9790314 0.967 rs336586 chr3:161081347 G/A cg03342759 chr3:160939853 NMD3 -0.49 -8.35 -0.42 1.85e-15 Morning vs. evening chronotype; LUSC cis rs9527 0.544 rs3781280 chr10:104863843 T/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.62 -0.34 1.4e-10 Arsenic metabolism; LUSC cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg06784218 chr1:46089804 CCDC17 -0.48 -9.7 -0.47 9.43e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7769051 1.000 rs9493454 chr6:133144629 G/T cg22852734 chr6:133119734 C6orf192 -1.11 -13.36 -0.59 6.33e-33 Type 2 diabetes nephropathy; LUSC cis rs240764 0.817 rs239216 chr6:101147892 T/G cg09795085 chr6:101329169 ASCC3 0.42 6.15 0.32 2.16e-9 Neuroticism; LUSC cis rs1008375 0.931 rs4479701 chr4:17571496 G/A cg18681998 chr4:17616180 MED28 0.83 14.53 0.62 2.08e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17850984 chr19:4246870 CCDC94 -0.43 -6.36 -0.33 6.77e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9951602 0.512 rs12454617 chr18:76656007 C/T cg02800362 chr5:177631904 HNRNPAB 0.87 12.81 0.57 8.07e-31 Obesity-related traits; LUSC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg09021430 chr5:549028 NA -0.57 -7.7 -0.39 1.61e-13 Obesity-related traits; LUSC cis rs7605827 0.897 rs10084390 chr2:15597662 C/A cg19274914 chr2:15703543 NA 0.46 8.8 0.43 7.47e-17 Educational attainment (years of education); LUSC trans rs2392780 0.536 rs452529 chr8:128333259 C/G cg10195415 chr17:73887371 TRIM65 -0.37 -6.09 -0.32 3.16e-9 Breast cancer (early onset); LUSC cis rs9527 0.615 rs3897401 chr10:104696379 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.08 0.4 1.19e-14 Arsenic metabolism; LUSC cis rs9611519 0.929 rs73174660 chr22:41437304 T/C cg13813247 chr22:41461852 NA -0.37 -6.75 -0.35 6.38e-11 Neuroticism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05076971 chr7:117824189 NAA38 -0.49 -5.97 -0.31 6.03e-9 Bipolar disorder and schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13264059 chr10:129705415 PTPRE -0.41 -6.31 -0.33 8.93e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1957429 0.634 rs7143541 chr14:65419777 G/T cg23373153 chr14:65346875 NA -0.87 -9.16 -0.45 5.54e-18 Pediatric areal bone mineral density (radius); LUSC cis rs12893668 0.616 rs58033365 chr14:104030901 T/C cg04998671 chr14:104000505 TRMT61A -0.47 -6.7 -0.34 9.1e-11 Reticulocyte count; LUSC cis rs7512552 0.724 rs7002 chr1:150445819 A/G cg15654264 chr1:150340011 RPRD2 0.65 10.85 0.51 1.1e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9457247 1.000 rs394522 chr6:167398071 A/C cg07741184 chr6:167504864 NA 0.36 6.53 0.34 2.52e-10 Crohn's disease; LUSC cis rs354225 0.544 rs13386146 chr2:54802514 G/C cg26097391 chr2:54893211 SPTBN1 0.45 6.82 0.35 4.21e-11 Schizophrenia; LUSC cis rs4891159 0.756 rs55763305 chr18:74161249 G/C cg24786174 chr18:74118243 ZNF516 -0.76 -13.67 -0.6 4.17e-34 Longevity; LUSC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.57 0.38 3.73e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 0.867 rs2899082 chr15:43656043 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.16 0.58 3.88e-32 Lung cancer in ever smokers; LUSC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg17366294 chr4:99064904 C4orf37 0.58 10.2 0.49 1.91e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4566357 0.615 rs12618793 chr2:227909552 T/C cg11843606 chr2:227700838 RHBDD1 -0.54 -8.37 -0.42 1.64e-15 Coronary artery disease; LUSC cis rs34421088 0.585 rs6992190 chr8:11596549 A/C cg13293535 chr8:11597251 GATA4 0.3 5.69 0.3 2.71e-8 Neuroticism; LUSC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg04865166 chr7:105162814 PUS7 0.51 5.65 0.3 3.36e-8 Bipolar disorder (body mass index interaction); LUSC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg02782426 chr3:40428986 ENTPD3 0.41 7.61 0.38 2.87e-13 Renal cell carcinoma; LUSC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 12.32 0.56 5.3e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13315871 0.929 rs11130627 chr3:58315749 G/A cg20936604 chr3:58311152 NA -0.76 -6.96 -0.36 1.78e-11 Cholesterol, total; LUSC cis rs4561483 0.801 rs40311 chr16:11963190 C/G cg08843971 chr16:11963173 GSPT1 0.48 7.18 0.37 4.52e-12 Testicular germ cell tumor; LUSC cis rs12310956 0.532 rs1589902 chr12:33989289 G/A cg06521331 chr12:34319734 NA -0.47 -7.55 -0.38 4.09e-13 Morning vs. evening chronotype; LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg00684032 chr4:1343700 KIAA1530 -0.36 -6.11 -0.32 2.82e-9 Obesity-related traits; LUSC trans rs6982636 0.967 rs2980860 chr8:126485337 A/G cg13325919 chr3:181432053 SOX2;SOX2OT -0.32 -6.36 -0.33 6.73e-10 Lipid metabolism phenotypes; LUSC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs908922 0.676 rs4845784 chr1:152494583 G/C cg20991723 chr1:152506922 NA 0.52 9.93 0.48 1.63e-20 Hair morphology; LUSC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg23758822 chr17:41437982 NA 1.04 19.18 0.72 7.95e-56 Menopause (age at onset); LUSC cis rs9650315 0.866 rs13266192 chr8:57195456 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.13 0.36 6.25e-12 Height; LUSC cis rs2236918 0.710 rs2797602 chr1:242029206 G/T cg17736920 chr1:242011382 EXO1 0.4 6.35 0.33 7.03e-10 Menopause (age at onset); LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.7 12.15 0.55 2.22e-28 Prudent dietary pattern; LUSC cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg24642439 chr20:33292090 TP53INP2 0.49 7.34 0.37 1.62e-12 Glomerular filtration rate (creatinine); LUSC cis rs17401966 0.931 rs2236678 chr1:10471789 A/T cg19773385 chr1:10388646 KIF1B -0.57 -9.61 -0.47 1.81e-19 Hepatocellular carcinoma; LUSC cis rs2274273 0.870 rs66696758 chr14:55766509 G/A cg04306507 chr14:55594613 LGALS3 0.54 12.08 0.55 3.86e-28 Protein biomarker; LUSC cis rs9325144 0.581 rs2653758 chr12:38946233 G/T cg26384229 chr12:38710491 ALG10B -0.7 -11.41 -0.53 1.06e-25 Morning vs. evening chronotype; LUSC cis rs6696846 0.749 rs61822566 chr1:205078660 T/C cg21643547 chr1:205240462 TMCC2 -0.38 -7.04 -0.36 1.11e-11 Red blood cell count; LUSC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 7.06 0.36 9.71e-12 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg27170947 chr2:26402098 FAM59B 0.72 10.52 0.5 1.48e-22 Gut microbiome composition (summer); LUSC cis rs7000551 0.725 rs2469757 chr8:22360938 C/T cg12081754 chr8:22256438 SLC39A14 0.43 6.44 0.33 4.11e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs9929218 0.551 rs2296405 chr16:68721470 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -1.06 -26.47 -0.82 5.08e-84 Colorectal cancer; LUSC cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.55 -7.03 -0.36 1.21e-11 Height; LUSC cis rs2242194 0.816 rs6671688 chr1:154994265 T/C cg06221963 chr1:154839813 KCNN3 -0.44 -8.9 -0.44 3.67e-17 Schizophrenia; LUSC cis rs2932538 0.961 rs2932534 chr1:113200797 A/G cg22162597 chr1:113214053 CAPZA1 0.64 9.46 0.46 5.76e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs4443100 0.916 rs8139695 chr22:23373902 A/T cg14186256 chr22:23484241 RTDR1 -0.48 -5.99 -0.31 5.39e-9 Serum parathyroid hormone levels; LUSC cis rs57590327 0.528 rs4856346 chr3:81502655 T/G cg07356753 chr3:81810745 GBE1 0.45 6.02 0.31 4.58e-9 Extraversion; LUSC cis rs826838 0.616 rs4619214 chr12:38614704 C/A cg13010199 chr12:38710504 ALG10B 0.48 7.28 0.37 2.47e-12 Heart rate; LUSC cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg24642439 chr20:33292090 TP53INP2 0.51 7.74 0.39 1.2e-13 Height; LUSC cis rs6964587 0.967 rs4729015 chr7:91561592 T/G cg17063962 chr7:91808500 NA -0.56 -8.69 -0.43 1.63e-16 Breast cancer; LUSC cis rs765787 0.530 rs28897155 chr15:45533974 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.7 -0.43 1.5e-16 Uric acid levels; LUSC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg15839431 chr19:19639596 YJEFN3 -0.4 -5.69 -0.3 2.76e-8 Tonsillectomy; LUSC cis rs7202877 0.656 rs3851736 chr16:75387332 T/C cg03315344 chr16:75512273 CHST6 0.45 6.67 0.34 1.07e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs13064411 0.696 rs6787026 chr3:113162117 A/G cg18753928 chr3:113234510 CCDC52 -0.51 -7.63 -0.39 2.53e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg21285383 chr16:89894308 SPIRE2 -0.35 -7.33 -0.37 1.75e-12 Vitiligo; LUSC cis rs56399783 0.901 rs73047393 chr7:2775879 C/T cg19731401 chr7:2775893 GNA12 0.73 8.92 0.44 3.05e-17 Childhood ear infection; LUSC cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg11266682 chr4:10021025 SLC2A9 0.53 10.0 0.48 9.14e-21 Bone mineral density; LUSC cis rs4319547 0.741 rs4758644 chr12:122943915 A/C cg05707623 chr12:122985044 ZCCHC8 -0.55 -7.06 -0.36 9.48e-12 Body mass index; LUSC trans rs2243480 1.000 rs1701750 chr7:65467145 T/C cg10756647 chr7:56101905 PSPH 0.85 8.28 0.41 3.01e-15 Diabetic kidney disease; LUSC cis rs6845621 0.901 rs9993984 chr4:18927087 G/A cg12196642 chr4:18937545 NA -0.35 -6.52 -0.34 2.55e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9925964 0.967 rs1978487 chr16:31129942 C/T cg02466173 chr16:30829666 NA -0.32 -5.85 -0.3 1.19e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9341808 0.530 rs3805877 chr6:81031529 T/A cg08355045 chr6:80787529 NA 0.51 8.89 0.44 3.84e-17 Sitting height ratio; LUSC cis rs2797160 1.000 rs2747725 chr6:126012397 A/C cg05901451 chr6:126070800 HEY2 0.54 7.85 0.39 5.56e-14 Endometrial cancer; LUSC cis rs3862435 0.764 rs12913819 chr15:91045928 T/C cg22089800 chr15:90895588 ZNF774 -0.55 -5.9 -0.31 9.05e-9 Response to exercise (triglyceride level interaction); LUSC cis rs6121246 0.609 rs2376998 chr20:30340663 T/C cg13852791 chr20:30311386 BCL2L1 0.93 14.15 0.61 6.1e-36 Mean corpuscular hemoglobin; LUSC cis rs9549367 0.789 rs12866090 chr13:113869410 G/A cg18105134 chr13:113819100 PROZ -0.75 -10.71 -0.51 3.38e-23 Platelet distribution width; LUSC cis rs314370 0.951 rs17881696 chr7:100493359 G/A cg10426581 chr7:100472382 SRRT 0.86 12.37 0.56 3.44e-29 Resting heart rate; LUSC cis rs12549902 0.966 rs17659386 chr8:41513531 T/C cg21772509 chr8:41503840 NKX6-3 0.64 10.42 0.5 3.4e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs2742234 0.590 rs2505553 chr10:43681251 G/T cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs12579753 0.871 rs4255611 chr12:82215969 C/A cg07988820 chr12:82153109 PPFIA2 -0.44 -6.21 -0.32 1.56e-9 Resting heart rate; LUSC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg08847533 chr14:75593920 NEK9 0.84 15.49 0.65 3.54e-41 Height; LUSC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7917772 0.604 rs4917977 chr10:104363119 C/T cg22532475 chr10:104410764 TRIM8 -0.25 -5.99 -0.31 5.4e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3008870 1.000 rs2985825 chr1:67412822 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.02 0.63 2.56e-39 Lymphocyte percentage of white cells; LUSC cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg01579765 chr21:45077557 HSF2BP -0.53 -10.97 -0.51 4.05e-24 Mean corpuscular volume; LUSC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs6547741 0.935 rs6749426 chr2:27847606 T/C cg12559939 chr2:27858050 GPN1 0.39 6.05 0.31 3.98e-9 Oral cavity cancer; LUSC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg15448220 chr1:150897856 SETDB1 0.43 6.26 0.32 1.21e-9 Melanoma; LUSC cis rs35883536 0.647 rs1995142 chr1:101041174 G/A cg06223162 chr1:101003688 GPR88 0.49 9.44 0.46 6.6e-19 Monocyte count; LUSC cis rs6430585 0.591 rs77096272 chr2:136663605 C/A cg07169764 chr2:136633963 MCM6 1.17 17.75 0.7 4.18e-50 Corneal structure; LUSC cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg05868516 chr6:26286170 HIST1H4H 0.36 5.87 0.31 1.05e-8 Educational attainment; LUSC cis rs459571 0.606 rs457420 chr9:136909261 A/G cg13789015 chr9:136890014 NCRNA00094 -0.66 -12.34 -0.56 4.6e-29 Platelet distribution width; LUSC cis rs1953600 0.521 rs7067644 chr10:81924245 A/G cg00277334 chr10:82204260 NA -0.43 -6.72 -0.35 7.72e-11 Sarcoidosis; LUSC cis rs3768617 0.510 rs3768624 chr1:183079252 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.84 0.51 1.15e-23 Fuchs's corneal dystrophy; LUSC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg00310523 chr12:86230176 RASSF9 0.47 8.63 0.43 2.61e-16 Major depressive disorder; LUSC cis rs1801251 0.752 rs709938 chr2:233746457 C/T cg08000102 chr2:233561755 GIGYF2 -0.52 -8.0 -0.4 2.13e-14 Coronary artery disease; LUSC cis rs11039100 1.000 rs12798823 chr11:5826716 T/G cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg13531842 chr10:38383804 ZNF37A -0.46 -7.23 -0.37 3.4e-12 Extrinsic epigenetic age acceleration; LUSC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg05313129 chr8:58192883 C8orf71 -0.55 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs997295 0.737 rs11631474 chr15:67934167 C/T cg08079166 chr15:68083412 MAP2K5 0.31 6.14 0.32 2.32e-9 Motion sickness; LUSC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.49 0.67 4.02e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.48 6.4 0.33 5.14e-10 Renal function-related traits (BUN); LUSC cis rs8141797 0.901 rs738808 chr22:24488461 C/T cg00411358 chr22:24577142 SUSD2 -0.61 -6.02 -0.31 4.6e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg06238570 chr21:40685208 BRWD1 0.47 7.3 0.37 2.08e-12 Cognitive function; LUSC trans rs10506458 0.915 rs17687426 chr12:63397900 G/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.02 -0.63 2.6e-39 Hemostatic factors and hematological phenotypes; LUSC cis rs11098499 0.955 rs35916640 chr4:120155852 T/C cg24375607 chr4:120327624 NA 0.75 11.42 0.53 9.94e-26 Corneal astigmatism; LUSC cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg05082376 chr22:42548792 NA 0.36 5.84 0.3 1.24e-8 Cognitive function; LUSC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.71 -0.34 8.1e-11 Lung cancer; LUSC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg24733560 chr20:60626293 TAF4 0.44 8.08 0.4 1.19e-14 Body mass index; LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.56 0.67 2.19e-45 Platelet count; LUSC cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC trans rs7786808 0.707 rs11770299 chr7:158228822 G/A cg02030672 chr11:45687055 CHST1 0.45 6.74 0.35 6.79e-11 Obesity-related traits; LUSC cis rs2439831 0.850 rs28509275 chr15:44098105 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.72 6.14 0.32 2.4e-9 Lung cancer in ever smokers; LUSC cis rs243505 0.632 rs887571 chr7:148505253 G/A cg09806900 chr7:148480153 CUL1 0.57 8.44 0.42 1e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs73206853 0.609 rs12311902 chr12:110883799 T/C cg12870014 chr12:110450643 ANKRD13A 0.5 5.9 0.31 9.03e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1891275 0.515 rs1418161 chr10:93484655 C/G cg07889827 chr10:93443413 NA -0.4 -9.1 -0.45 8.58e-18 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25492241 chr3:159482591 SCHIP1 0.72 6.77 0.35 5.84e-11 Cognitive performance; LUSC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.8 9.12 0.45 7.28e-18 Mean platelet volume; LUSC cis rs35306767 0.623 rs72760943 chr10:1143104 G/A cg20503657 chr10:835505 NA 0.52 6.27 0.32 1.12e-9 Eosinophil percentage of granulocytes; LUSC cis rs2486288 0.656 rs12911186 chr15:45551423 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.89 -0.4 4.34e-14 Glomerular filtration rate; LUSC cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs5758511 0.514 rs9607882 chr22:42567451 A/G cg00645731 chr22:42541494 CYP2D7P1 0.58 9.8 0.47 4.25e-20 Birth weight; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg02951883 chr7:2050386 MAD1L1 -0.45 -7.66 -0.39 2.07e-13 Bipolar disorder and schizophrenia; LUSC trans rs7939886 0.920 rs7934132 chr11:55942463 T/A cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg05347473 chr6:146136440 FBXO30 0.51 8.39 0.42 1.43e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2282300 1.000 rs12796693 chr11:30429583 A/C cg25418670 chr11:30344373 C11orf46 -0.47 -6.28 -0.32 1.06e-9 Morning vs. evening chronotype; LUSC trans rs1325195 0.920 rs2816167 chr1:179200657 T/G cg11624085 chr17:8464688 MYH10 0.44 6.97 0.36 1.7e-11 IgE grass sensitization; LUSC cis rs68170813 0.559 rs997311 chr7:106953033 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.83 -0.3 1.29e-8 Coronary artery disease; LUSC cis rs7523273 0.586 rs2796276 chr1:207951513 G/A cg22525895 chr1:207977042 MIR29B2 0.42 6.71 0.34 8.25e-11 Schizophrenia; LUSC trans rs7937682 0.921 rs4534611 chr11:111440425 C/G cg18187862 chr3:45730750 SACM1L 0.53 6.62 0.34 1.46e-10 Primary sclerosing cholangitis; LUSC cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg06064525 chr11:970664 AP2A2 0.48 10.63 0.5 6.39e-23 Alzheimer's disease (late onset); LUSC cis rs10979 1.000 rs1416207 chr6:143889275 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs9463078 0.547 rs764396 chr6:44710691 C/G cg25276700 chr6:44698697 NA 0.3 6.2 0.32 1.66e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs753955 0.593 rs7982516 chr13:24410278 A/G cg03803002 chr8:141110260 TRAPPC9 -0.34 -6.07 -0.32 3.45e-9 Lung cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00144817 chr8:17503298 MTUS1 -0.76 -6.28 -0.32 1.08e-9 Cognitive performance; LUSC cis rs10744422 1.000 rs12255 chr12:123350204 C/T cg25930673 chr12:123319894 HIP1R -0.6 -6.06 -0.31 3.7e-9 Schizophrenia; LUSC cis rs240764 0.658 rs7740006 chr6:101220432 T/C cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.29e-9 Neuroticism; LUSC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg05585544 chr11:47624801 NA -0.42 -7.35 -0.37 1.55e-12 Subjective well-being; LUSC cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg00343986 chr7:65444356 GUSB 0.4 5.93 0.31 7.43e-9 Aortic root size; LUSC cis rs11955175 1.000 rs77394428 chr5:40743517 A/G cg05478818 chr5:40835740 RPL37 0.74 5.84 0.3 1.27e-8 Bipolar disorder and schizophrenia; LUSC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg12365402 chr11:9010492 NRIP3 -0.47 -8.71 -0.43 1.39e-16 Hemoglobin concentration; LUSC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.13 0.41 8.35e-15 Prudent dietary pattern; LUSC cis rs11098499 0.615 rs28850368 chr4:120554313 G/A cg09307838 chr4:120376055 NA 0.65 9.89 0.48 2.06e-20 Corneal astigmatism; LUSC cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg15556689 chr8:8085844 FLJ10661 0.67 10.39 0.49 4.1e-22 Neuroticism; LUSC cis rs2249625 0.508 rs114505309 chr6:72892383 G/A cg18830697 chr6:72922368 RIMS1 0.38 7.67 0.39 1.87e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs7267979 0.903 rs6050482 chr20:25226327 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 17.55 0.69 2.62e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4072705 0.616 rs915033 chr9:127245558 C/G cg13476313 chr9:127244764 NR5A1 0.33 6.5 0.34 2.91e-10 Menarche (age at onset); LUSC cis rs1355223 0.525 rs12280958 chr11:34872799 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.74 -0.35 7e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg24733560 chr20:60626293 TAF4 0.41 6.77 0.35 5.69e-11 Body mass index; LUSC cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg25251562 chr2:3704773 ALLC 0.56 9.28 0.45 2.13e-18 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs4820539 1.000 rs13054985 chr22:23458577 G/A cg14186256 chr22:23484241 RTDR1 0.96 17.5 0.69 4.01e-49 Bone mineral density; LUSC cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg19920283 chr7:105172520 RINT1 0.64 7.1 0.36 7.7e-12 Bipolar disorder (body mass index interaction); LUSC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.06 -0.48 5.7e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12541635 0.966 rs7819043 chr8:106989783 T/C cg10147462 chr8:107024639 NA 0.56 10.1 0.48 4.04e-21 Age of smoking initiation; LUSC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg21856205 chr7:94953877 PON1 -0.36 -5.94 -0.31 7.32e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg07507251 chr3:52567010 NT5DC2 0.33 6.38 0.33 5.76e-10 Bipolar disorder; LUSC cis rs62400317 0.826 rs12205468 chr6:45310285 G/A cg18551225 chr6:44695536 NA -0.44 -7.41 -0.38 1.03e-12 Total body bone mineral density; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg21280719 chr6:42927975 GNMT -0.31 -7.8 -0.39 7.73e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.44e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.684 rs2454451 chr15:76861461 G/T cg23625390 chr15:77176239 SCAPER 0.67 10.14 0.49 3.04e-21 Blood metabolite levels; LUSC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg14019146 chr3:50243930 SLC38A3 -0.36 -8.19 -0.41 5.48e-15 Body mass index; LUSC cis rs2806561 0.514 rs10917360 chr1:23539010 C/T cg19743168 chr1:23544995 NA 0.55 11.05 0.52 2.13e-24 Height; LUSC cis rs983392 0.667 rs662196 chr11:59942757 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.28 0.33 1.03e-9 Alzheimer's disease (late onset); LUSC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg18681998 chr4:17616180 MED28 0.84 15.61 0.65 1.21e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg08280861 chr8:58055591 NA 0.57 6.2 0.32 1.67e-9 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg07701084 chr6:150067640 NUP43 0.55 8.32 0.41 2.23e-15 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19467738 chr11:94823267 ENDOD1 -0.43 -6.4 -0.33 5.14e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4808199 0.901 rs12973258 chr19:19488718 T/C cg03709012 chr19:19516395 GATAD2A 1.15 15.33 0.64 1.56e-40 Nonalcoholic fatty liver disease; LUSC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 13.04 0.58 1.06e-31 Hip circumference adjusted for BMI; LUSC cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg13010199 chr12:38710504 ALG10B 0.58 9.24 0.45 2.96e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.66 -0.43 2.01e-16 Bipolar disorder; LUSC cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg23029597 chr12:123009494 RSRC2 -0.72 -9.33 -0.45 1.51e-18 Body mass index; LUSC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg19748678 chr4:122722346 EXOSC9 0.66 9.94 0.48 1.44e-20 Type 2 diabetes; LUSC trans rs9650657 0.682 rs6989160 chr8:10705360 A/C cg15556689 chr8:8085844 FLJ10661 -0.41 -6.13 -0.32 2.44e-9 Neuroticism; LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg04166393 chr7:2884313 GNA12 0.43 5.85 0.3 1.18e-8 Height; LUSC cis rs644799 0.526 rs693172 chr11:95636618 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.61 8.72 0.43 1.29e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -6.61 -0.34 1.52e-10 Bipolar disorder; LUSC cis rs829883 0.659 rs11109520 chr12:98928646 C/T cg25150519 chr12:98850993 NA 0.64 8.87 0.44 4.44e-17 Colorectal adenoma (advanced); LUSC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg15649852 chr7:65879115 NA -0.4 -5.65 -0.3 3.47e-8 Aortic root size; LUSC cis rs9443645 0.505 rs11752126 chr6:79707923 C/T cg05283184 chr6:79620031 NA -0.45 -8.61 -0.43 2.94e-16 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.85 0.3 1.18e-8 Menopause (age at onset); LUSC cis rs9906944 0.707 rs3816272 chr17:47120467 A/G cg14634687 chr17:47094252 IGF2BP1 0.31 6.59 0.34 1.75e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg09365446 chr1:150670422 GOLPH3L 0.48 7.07 0.36 9.1e-12 Melanoma; LUSC cis rs6977660 0.607 rs10243965 chr7:19797893 G/A cg05791153 chr7:19748676 TWISTNB 0.75 7.89 0.4 4.47e-14 Thyroid stimulating hormone; LUSC cis rs8062405 0.691 rs743590 chr16:28608230 G/A cg16576597 chr16:28551801 NUPR1 0.3 6.02 0.31 4.57e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2486288 0.656 rs8039153 chr15:45579813 T/C cg09092052 chr15:45571596 NA 0.44 6.13 0.32 2.43e-9 Glomerular filtration rate; LUSC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg06212747 chr3:49208901 KLHDC8B 0.59 8.35 0.42 1.89e-15 Menarche (age at onset); LUSC cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg21535247 chr6:8435926 SLC35B3 0.58 8.98 0.44 2.03e-17 Motion sickness; LUSC cis rs11098499 0.863 rs11723090 chr4:120490592 T/C cg24375607 chr4:120327624 NA 0.77 11.56 0.53 3.04e-26 Corneal astigmatism; LUSC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg08773314 chr2:239334832 ASB1 -0.42 -9.06 -0.44 1.15e-17 Multiple system atrophy; LUSC cis rs7804356 1.000 rs2030136 chr7:26891016 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.39e-9 Type 1 diabetes; LUSC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg24768116 chr2:27665128 KRTCAP3 -0.31 -6.14 -0.32 2.32e-9 Total body bone mineral density; LUSC cis rs17608059 0.504 rs11656981 chr17:13978777 A/G cg27005118 chr17:13972210 COX10 -0.49 -9.11 -0.45 7.82e-18 Temperament; LUSC cis rs614226 1.000 rs563920 chr12:121017439 A/G cg21053147 chr12:120880522 NA -0.48 -5.79 -0.3 1.61e-8 Type 1 diabetes nephropathy; LUSC cis rs16854884 0.657 rs6778627 chr3:143720869 G/T cg06585982 chr3:143692056 C3orf58 0.48 7.5 0.38 5.7e-13 Economic and political preferences (feminism/equality); LUSC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg18681998 chr4:17616180 MED28 0.84 15.61 0.65 1.21e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs727505 0.789 rs66756015 chr7:124740641 C/A cg23710748 chr7:124431027 NA -0.4 -7.04 -0.36 1.08e-11 Lewy body disease; LUSC cis rs9549260 0.564 rs9315784 chr13:41289166 G/A cg21288729 chr13:41239152 FOXO1 0.55 8.3 0.41 2.7e-15 Red blood cell count; LUSC cis rs7296418 0.922 rs1727293 chr12:123648032 C/T cg00376283 chr12:123451042 ABCB9 0.78 11.88 0.55 2.13e-27 Platelet count; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg00451227 chr4:185975098 NA -0.34 -6.08 -0.32 3.21e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg18352616 chr4:3374830 RGS12 0.28 5.79 0.3 1.61e-8 Parental longevity (mother's age at death); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16655905 chr19:38755330 SPINT2 0.8 6.33 0.33 7.7e-10 Cognitive performance; LUSC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -9.67 -0.47 1.13e-19 Developmental language disorder (linguistic errors); LUSC cis rs12519773 0.502 rs67862943 chr5:92529268 G/A cg18783429 chr5:92414398 NA 0.32 6.68 0.34 1.02e-10 Migraine; LUSC cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg08999081 chr20:33150536 PIGU 0.42 7.81 0.39 7.3e-14 Coronary artery disease; LUSC cis rs12497850 0.863 rs4858799 chr3:48728204 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.02 0.4 1.82e-14 Parkinson's disease; LUSC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.49e-10 Extrinsic epigenetic age acceleration; LUSC cis rs1950626 0.833 rs72700524 chr14:101417309 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.42 7.46 0.38 7.73e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs11229555 0.645 rs34054511 chr11:58204943 A/C cg15696309 chr11:58395628 NA -0.6 -7.32 -0.37 1.87e-12 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg23283495 chr1:209979779 IRF6 0.78 15.77 0.65 2.87e-42 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC trans rs12637928 0.560 rs17726773 chr3:110151055 G/A cg17371621 chr15:61264283 RORA 0.36 5.94 0.31 7.03e-9 Neuroticism; LUSC cis rs1832871 0.643 rs112195967 chr6:158775695 C/T cg07165851 chr6:158734300 TULP4 0.47 7.23 0.37 3.42e-12 Height; LUSC cis rs7824557 1.000 rs2736371 chr8:11105529 A/G cg21775007 chr8:11205619 TDH -0.51 -7.5 -0.38 5.89e-13 Retinal vascular caliber; LUSC cis rs2180341 0.640 rs11154395 chr6:127629138 T/C cg27446573 chr6:127587934 RNF146 0.64 10.38 0.49 4.67e-22 Breast cancer; LUSC cis rs2282300 0.637 rs1765131 chr11:30404538 G/C cg25418670 chr11:30344373 C11orf46 -0.41 -6.35 -0.33 7.02e-10 Morning vs. evening chronotype; LUSC cis rs4718428 1.000 rs1830070 chr7:66349671 T/C cg18252515 chr7:66147081 NA -0.4 -6.01 -0.31 4.93e-9 Corneal structure; LUSC cis rs7809950 1.000 rs10234355 chr7:107086517 T/G cg23024343 chr7:107201750 COG5 -0.55 -8.76 -0.43 1.01e-16 Coronary artery disease; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg02951883 chr7:2050386 MAD1L1 -0.39 -6.74 -0.35 7.1e-11 Bipolar disorder and schizophrenia; LUSC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg03709012 chr19:19516395 GATAD2A 0.85 13.9 0.61 5.48e-35 Tonsillectomy; LUSC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg20573242 chr4:122745356 CCNA2 0.42 6.52 0.34 2.6200000000000003e-10 Type 2 diabetes; LUSC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7605827 0.930 rs13016997 chr2:15699240 A/T cg19274914 chr2:15703543 NA 0.47 9.14 0.45 6.29e-18 Educational attainment (years of education); LUSC trans rs10432489 0.708 rs10178270 chr2:181773395 G/C cg11196870 chr8:41386826 GINS4 0.93 6.32 0.33 8.44e-10 QT interval; LUSC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg16989086 chr20:62203971 PRIC285 0.45 6.34 0.33 7.32e-10 Glioblastoma; LUSC cis rs2050392 0.517 rs160018 chr10:30772703 T/C cg25182066 chr10:30743637 MAP3K8 -0.45 -6.64 -0.34 1.3e-10 Inflammatory bowel disease; LUSC cis rs8014204 0.743 rs35809608 chr14:75254762 A/G cg06637938 chr14:75390232 RPS6KL1 0.65 10.68 0.5 4.38e-23 Caffeine consumption; LUSC cis rs4919694 0.572 rs4917995 chr10:104845443 A/T cg04362960 chr10:104952993 NT5C2 -0.87 -11.2 -0.52 6e-25 Arsenic metabolism; LUSC cis rs11155671 0.530 rs4870080 chr6:150202644 T/C cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.64e-10 Testicular germ cell tumor; LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.19 0.64 5.59e-40 Platelet count; LUSC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs11608355 0.521 rs6606704 chr12:109814036 T/C cg19025524 chr12:109796872 NA -0.41 -7.71 -0.39 1.5e-13 Neuroticism; LUSC cis rs713477 1.000 rs8014526 chr14:55885054 C/G cg13175173 chr14:55914753 NA -0.3 -6.19 -0.32 1.81e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg12963246 chr6:28129442 ZNF389 0.48 6.7 0.34 8.74e-11 Depression; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.23 0.41 4.36e-15 Prudent dietary pattern; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs367615 0.661 rs9326773 chr5:108833523 C/T cg17395555 chr5:108820864 NA 0.65 11.94 0.55 1.34e-27 Colorectal cancer (SNP x SNP interaction); LUSC cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg18964960 chr10:1102726 WDR37 -0.45 -6.13 -0.32 2.54e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg08999081 chr20:33150536 PIGU -0.41 -7.56 -0.38 3.88e-13 Glomerular filtration rate (creatinine); LUSC trans rs3733585 0.699 rs6449158 chr4:9960459 T/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3772130 0.961 rs34667636 chr3:121353291 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.67 9.62 0.47 1.71e-19 Cognitive performance; LUSC cis rs954108 0.809 rs1792023 chr13:29368502 G/A cg11788234 chr13:29393811 NA -0.38 -6.61 -0.34 1.49e-10 Obesity-related traits; LUSC trans rs11098499 0.954 rs17009122 chr4:120362403 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.17 0.32 2.01e-9 Corneal astigmatism; LUSC trans rs9929218 0.529 rs17715450 chr16:68729785 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.03 21.4 0.76 1.41e-64 Colorectal cancer; LUSC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg12257692 chr3:49977190 RBM6 0.25 6.88 0.35 2.97e-11 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg20135002 chr11:47629003 NA 0.48 7.54 0.38 4.4e-13 Subjective well-being; LUSC cis rs2046867 0.862 rs7648954 chr3:72838756 C/A cg25664220 chr3:72788482 NA -0.69 -11.74 -0.54 6.79e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs8072100 0.713 rs9895776 chr17:45486003 A/G cg08085267 chr17:45401833 C17orf57 -0.5 -7.25 -0.37 2.97e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg05855489 chr10:104503620 C10orf26 -0.69 -10.09 -0.48 4.4e-21 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05760393 chr11:2466141 KCNQ1 0.41 6.49 0.33 3.19e-10 Asthma; LUSC cis rs17621444 0.522 rs10788017 chr10:121805225 T/A cg02041677 chr10:121771263 NA -0.35 -6.59 -0.34 1.75e-10 IgG glycosylation; LUSC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg21285383 chr16:89894308 SPIRE2 0.35 7.36 0.37 1.43e-12 Vitiligo; LUSC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg03804128 chr16:635623 NA 0.3 5.84 0.3 1.26e-8 Height; LUSC trans rs7395662 0.517 rs10838960 chr11:48584741 A/G cg03929089 chr4:120376271 NA -0.44 -6.05 -0.31 3.92e-9 HDL cholesterol; LUSC cis rs6503525 0.628 rs4065985 chr17:38101932 G/C cg26162295 chr17:38119207 GSDMA -0.3 -7.07 -0.36 9.38e-12 Asthma; LUSC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg25427524 chr10:38739819 LOC399744 -0.74 -14.06 -0.61 1.38e-35 Extrinsic epigenetic age acceleration; LUSC cis rs250677 0.652 rs168751 chr5:148438264 C/T cg18129178 chr5:148520854 ABLIM3 -0.77 -10.83 -0.51 1.24e-23 Breast cancer; LUSC cis rs983392 0.667 rs624663 chr11:59945065 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.28 0.33 1.03e-9 Alzheimer's disease (late onset); LUSC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg19774624 chr17:42201019 HDAC5 0.67 9.6 0.47 1.98e-19 Total body bone mineral density; LUSC cis rs11642862 0.901 rs76345698 chr16:30946165 G/A cg02466173 chr16:30829666 NA -0.65 -6.41 -0.33 5.04e-10 Tonsillectomy; LUSC cis rs68170813 0.559 rs79543528 chr7:106891090 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.71 -0.47 8.54e-20 Coronary artery disease; LUSC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg21573476 chr21:45109991 RRP1B -0.38 -6.32 -0.33 8.38e-10 Mean corpuscular volume; LUSC cis rs9549367 0.724 rs7985335 chr13:113869244 G/T cg00898013 chr13:113819073 PROZ 0.54 8.29 0.41 2.8e-15 Platelet distribution width; LUSC cis rs6701037 0.555 rs10912898 chr1:175120469 A/G cg00321850 chr1:175162397 KIAA0040 -0.36 -5.95 -0.31 6.91e-9 Alcohol dependence; LUSC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg26677194 chr12:130822605 PIWIL1 0.59 8.78 0.43 8.41e-17 Menopause (age at onset); LUSC cis rs2075671 0.903 rs11760602 chr7:100264128 G/C cg16850897 chr7:100343110 ZAN -0.57 -7.81 -0.39 7.66e-14 Other erythrocyte phenotypes; LUSC cis rs9462027 0.585 rs2814974 chr6:34572028 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.15 -0.32 2.19e-9 Systemic lupus erythematosus; LUSC cis rs769267 0.598 rs8108705 chr19:19675367 G/T cg03709012 chr19:19516395 GATAD2A -0.51 -7.32 -0.37 1.84e-12 Tonsillectomy; LUSC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg03161606 chr19:29218774 NA 0.62 10.01 0.48 8.23e-21 Methadone dose in opioid dependence; LUSC cis rs6546537 0.955 rs7590422 chr2:69883715 T/C cg10773587 chr2:69614142 GFPT1 -0.47 -7.29 -0.37 2.26e-12 Serum thyroid-stimulating hormone levels; LUSC cis rs4343996 0.967 rs10250444 chr7:3350027 A/G cg21248987 chr7:3385318 SDK1 -0.38 -6.43 -0.33 4.54e-10 Motion sickness; LUSC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg16049864 chr8:95962084 TP53INP1 0.62 10.88 0.51 8.36e-24 Type 2 diabetes; LUSC cis rs7208859 0.524 rs11653605 chr17:29088385 T/G cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs12594515 1.000 rs56412446 chr15:45996424 A/G cg19682013 chr15:45996608 NA 0.39 5.8 0.3 1.51e-8 Waist circumference;Weight; LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg07217954 chr7:1067459 C7orf50 0.53 5.71 0.3 2.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg03433033 chr1:76189801 ACADM -0.7 -9.52 -0.46 3.67e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7605378 1.000 rs797163 chr2:200696387 G/A cg17644776 chr2:200775616 C2orf69 0.39 6.28 0.33 1.04e-9 Osteoporosis; LUSC cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg08085267 chr17:45401833 C17orf57 -0.47 -6.62 -0.34 1.47e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9309473 0.583 rs6713196 chr2:73576405 T/C cg20560298 chr2:73613845 ALMS1 -0.59 -8.83 -0.43 6.22e-17 Metabolite levels; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.03 -0.4 1.71e-14 Lymphocyte counts; LUSC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg13939156 chr17:80058883 NA -0.33 -6.6 -0.34 1.59e-10 Life satisfaction; LUSC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg14668632 chr7:2872130 GNA12 -0.43 -6.76 -0.35 6.14e-11 Height; LUSC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC cis rs7819412 0.691 rs73198970 chr8:11040216 T/C cg21775007 chr8:11205619 TDH -0.49 -6.82 -0.35 4.27e-11 Triglycerides; LUSC cis rs2074585 0.560 rs1973537 chr15:91062901 T/C cg22089800 chr15:90895588 ZNF774 -0.57 -8.1 -0.41 1.04e-14 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs3106136 0.934 rs17376404 chr4:95224046 T/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.25 -0.32 1.29e-9 Capecitabine sensitivity; LUSC cis rs36093844 0.898 rs80079882 chr11:85590955 T/C cg25872744 chr11:85566296 CCDC83 -0.42 -6.2 -0.32 1.64e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6693567 0.565 rs1262432 chr1:150371839 C/A cg15654264 chr1:150340011 RPRD2 0.45 7.18 0.37 4.41e-12 Migraine; LUSC cis rs56399783 0.901 rs7803944 chr7:2809087 G/A cg19731401 chr7:2775893 GNA12 0.61 8.35 0.42 1.86e-15 Childhood ear infection; LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg14092988 chr3:52407081 DNAH1 0.33 6.4 0.33 5.38e-10 Bipolar disorder; LUSC cis rs7043114 0.525 rs7869742 chr9:95256174 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.26 -0.32 1.18e-9 Height; LUSC cis rs908922 0.676 rs12116609 chr1:152497685 C/T cg20991723 chr1:152506922 NA 0.53 9.76 0.47 5.9e-20 Hair morphology; LUSC cis rs860295 0.812 rs4278368 chr1:155722557 G/A cg08949192 chr1:155289623 RUSC1;FDPS -0.34 -5.72 -0.3 2.38e-8 Body mass index; LUSC trans rs7937682 0.883 rs1784775 chr11:111472460 T/C cg18187862 chr3:45730750 SACM1L 0.52 6.65 0.34 1.2e-10 Primary sclerosing cholangitis; LUSC cis rs1018836 0.608 rs1033348 chr8:91464169 C/G cg16814680 chr8:91681699 NA -0.53 -7.67 -0.39 1.89e-13 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7909074 1.000 rs4948927 chr10:45397071 G/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.8 -0.43 7.41e-17 Mean corpuscular volume; LUSC cis rs2282032 0.883 rs2094653 chr14:90784827 A/G cg14092571 chr14:90743983 NA 0.5 6.53 0.34 2.49e-10 Longevity; LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.47 0.33 3.46e-10 Menopause (age at onset); LUSC cis rs2346177 0.844 rs12991646 chr2:46643831 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.57 -0.38 3.57e-13 HDL cholesterol; LUSC cis rs1577917 0.917 rs4098044 chr6:86462066 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.82 -0.43 6.39e-17 Response to antipsychotic treatment; LUSC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs6138458 1.000 rs227631 chr20:24913653 A/G cg26195577 chr20:24973756 C20orf3 1.11 18.4 0.71 1.06e-52 Blood protein levels; LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs151234 0.741 rs11074908 chr16:28608356 C/T cg01378222 chr16:28622494 SULT1A1 -0.63 -7.99 -0.4 2.17e-14 Platelet distribution width; LUSC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg15335139 chr3:50242325 SLC38A3 -0.25 -5.71 -0.3 2.5e-8 Body mass index; LUSC cis rs75229567 0.618 rs35394896 chr12:70188346 T/A cg10114359 chr12:70132523 RAB3IP 1.0 9.94 0.48 1.4e-20 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs1775715 0.966 rs1639132 chr10:32301260 G/A cg26784012 chr10:32216390 ARHGAP12 -0.37 -6.04 -0.31 4.18e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs6977660 0.619 rs12530799 chr7:19782793 G/A cg07541023 chr7:19748670 TWISTNB 0.63 6.65 0.34 1.23e-10 Thyroid stimulating hormone; LUSC cis rs6693567 0.565 rs696615 chr1:150338988 A/C cg15654264 chr1:150340011 RPRD2 0.44 6.92 0.35 2.34e-11 Migraine; LUSC cis rs12760731 0.720 rs12026110 chr1:178410984 G/A cg00404053 chr1:178313656 RASAL2 0.59 6.22 0.32 1.46e-9 Obesity-related traits; LUSC trans rs61931739 0.517 rs11052977 chr12:34035030 A/C cg26384229 chr12:38710491 ALG10B 0.7 10.93 0.51 5.66e-24 Morning vs. evening chronotype; LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg18404041 chr3:52824283 ITIH1 -0.57 -11.01 -0.52 2.85e-24 Bipolar disorder; LUSC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg19046167 chr17:80928561 B3GNTL1 -0.44 -6.51 -0.34 2.83e-10 Breast cancer; LUSC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg14689365 chr7:158441557 NCAPG2 0.53 8.31 0.41 2.4e-15 Height; LUSC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg15316289 chr22:50310904 ALG12;CRELD2 0.4 5.67 0.3 3.1e-8 Schizophrenia; LUSC cis rs9653442 0.675 rs7605430 chr2:100647552 C/G cg22139774 chr2:100720529 AFF3 0.45 8.02 0.4 1.85e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg21770322 chr7:97807741 LMTK2 0.4 7.01 0.36 1.31e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.83 -0.3 1.32e-8 Lung cancer; LUSC cis rs231513 0.954 rs231505 chr17:41970268 A/T cg26893861 chr17:41843967 DUSP3 0.47 6.03 0.31 4.33e-9 Cognitive function; LUSC cis rs2933343 0.621 rs4927921 chr3:128568868 A/G cg11901034 chr3:128598214 ACAD9 0.43 7.0 0.36 1.41e-11 IgG glycosylation; LUSC cis rs9419702 0.614 rs9419567 chr10:133535149 C/G cg23460707 chr10:133558971 NA 0.35 6.01 0.31 4.86e-9 Survival in rectal cancer; LUSC cis rs1215050 0.740 rs13134479 chr4:99067723 G/A cg05340658 chr4:99064831 C4orf37 0.45 7.22 0.37 3.57e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs66887589 0.967 rs56173225 chr4:120509972 G/A cg09307838 chr4:120376055 NA -0.47 -7.14 -0.36 5.8e-12 Diastolic blood pressure; LUSC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg10523679 chr1:76189770 ACADM 0.91 14.42 0.62 5.59e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1559088 0.947 rs12461219 chr19:33550633 C/G cg27124370 chr19:33622961 WDR88 0.53 6.8 0.35 4.84e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg11584989 chr19:19387371 SF4 0.58 6.97 0.36 1.74e-11 Bipolar disorder; LUSC trans rs9392918 0.587 rs12212270 chr6:7709341 A/C cg12631351 chr5:80256738 RASGRF2 -0.38 -6.04 -0.31 4.04e-9 Height; LUSC cis rs12956009 0.518 rs3902716 chr18:44889441 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.4 0.33 5.4e-10 Educational attainment (years of education); LUSC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg20503657 chr10:835505 NA 0.79 9.84 0.47 3.22e-20 Eosinophil percentage of granulocytes; LUSC cis rs1267303 0.798 rs1267304 chr1:46990426 C/T cg25110126 chr1:46999211 NA -0.69 -9.68 -0.47 1.05e-19 Monobrow; LUSC cis rs3770081 1.000 rs2303340 chr2:86333193 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -1.02 -7.07 -0.36 9.18e-12 Facial emotion recognition (sad faces); LUSC cis rs1538970 0.961 rs7553318 chr1:45843086 A/G cg05343316 chr1:45956843 TESK2 0.61 8.47 0.42 7.76e-16 Platelet count; LUSC trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs4363385 0.747 rs885096 chr1:152971313 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.74 -0.39 1.21e-13 Inflammatory skin disease; LUSC cis rs79349575 0.783 rs4794003 chr17:47029904 C/T cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC cis rs17401966 0.540 rs6541084 chr1:10285447 A/G cg19773385 chr1:10388646 KIF1B -0.36 -6.13 -0.32 2.51e-9 Hepatocellular carcinoma; LUSC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg20135002 chr11:47629003 NA -0.48 -7.55 -0.38 4.19e-13 Subjective well-being; LUSC cis rs9875589 0.509 rs2607757 chr3:14081948 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.39 -6.92 -0.35 2.32e-11 Ovarian reserve; LUSC cis rs829883 0.622 rs4762498 chr12:98964737 A/G cg25150519 chr12:98850993 NA -0.63 -8.64 -0.43 2.44e-16 Colorectal adenoma (advanced); LUSC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg21724239 chr8:58056113 NA 0.51 6.25 0.32 1.23e-9 Developmental language disorder (linguistic errors); LUSC trans rs6561151 0.681 rs4942249 chr13:44426804 C/A cg12856521 chr11:46389249 DGKZ 0.75 9.56 0.46 2.63e-19 Crohn's disease; LUSC cis rs459571 0.635 rs379471 chr9:136890649 G/A cg01294253 chr9:136912663 BRD3 0.36 6.24 0.32 1.34e-9 Platelet distribution width; LUSC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg13319975 chr6:146136371 FBXO30 0.72 11.13 0.52 1.11e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs7580658 0.929 rs4662575 chr2:128022215 C/T cg09760422 chr2:128146352 NA -0.32 -7.05 -0.36 1.02e-11 Protein C levels; LUSC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -7.16 -0.36 5.1e-12 Developmental language disorder (linguistic errors); LUSC cis rs2361710 0.611 rs12451471 chr17:78102517 C/T cg06718696 chr17:78121285 EIF4A3 0.62 9.09 0.45 9.2e-18 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC trans rs4596713 0.508 rs59620993 chr9:71771911 C/T cg25283916 chr1:242222868 NA -0.31 -6.3 -0.33 9.33e-10 Headache; LUSC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg20243544 chr17:37824526 PNMT 0.48 6.1 0.32 3e-9 Glomerular filtration rate (creatinine); LUSC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg09849774 chr21:43526787 UMODL1;C21orf128 -0.49 -7.3 -0.37 2.19e-12 IgG glycosylation; LUSC cis rs11229555 0.874 rs11229519 chr11:58310587 C/T cg15696309 chr11:58395628 NA -0.69 -8.94 -0.44 2.61e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg22963979 chr7:1858916 MAD1L1 -0.74 -12.73 -0.57 1.57e-30 Bipolar disorder and schizophrenia; LUSC cis rs9311676 0.656 rs55964615 chr3:58389120 A/T cg13750441 chr3:58318267 PXK 0.35 6.73 0.35 7.31e-11 Systemic lupus erythematosus; LUSC cis rs17604090 0.887 rs850013 chr7:29666530 T/C cg19413766 chr7:29689036 LOC646762 -0.55 -7.01 -0.36 1.31e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.64 -8.48 -0.42 7.18e-16 Alzheimer's disease; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.56 -8.53 -0.42 5.35e-16 Lymphocyte counts; LUSC cis rs929354 0.935 rs1182392 chr7:157036200 C/T cg17757837 chr7:157058334 UBE3C -0.84 -13.98 -0.61 2.87e-35 Body mass index; LUSC cis rs3857536 0.730 rs7761295 chr6:66932532 G/A cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs2413583 0.591 rs76449672 chr22:39696482 G/A cg17798944 chr22:39715225 SNORD43;RPL3 0.66 6.54 0.34 2.36e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg20891283 chr12:69753455 YEATS4 -0.68 -10.73 -0.51 2.93e-23 Blood protein levels; LUSC cis rs11048434 0.723 rs1805737 chr12:9084670 A/T cg23795048 chr12:9217529 LOC144571 0.34 5.77 0.3 1.84e-8 Sjögren's syndrome; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg00684032 chr4:1343700 KIAA1530 0.37 6.54 0.34 2.32e-10 Obesity-related traits; LUSC cis rs10078 0.510 rs2278248 chr5:469570 G/T cg08916839 chr5:415575 AHRR 0.66 6.72 0.35 7.72e-11 Fat distribution (HIV); LUSC cis rs1372520 0.748 rs1471484 chr4:90754313 C/T cg14346243 chr4:90757452 SNCA -0.41 -5.83 -0.3 1.34e-8 Neuroticism; LUSC trans rs724744 0.772 rs1737225 chr6:22353202 T/G cg13807341 chr11:118445984 ARCN1 -0.36 -6.19 -0.32 1.77e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs4285028 0.948 rs1920291 chr3:121672440 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.49 -0.46 4.55e-19 Multiple sclerosis; LUSC trans rs2262909 0.893 rs4244912 chr19:22203237 T/A cg17074339 chr11:11642133 GALNTL4 -0.41 -6.2 -0.32 1.68e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs5758511 0.680 rs5758667 chr22:42633204 G/A cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.89 -0.31 9.19e-9 Birth weight; LUSC cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.68 -0.5 4.17e-23 Monocyte percentage of white cells; LUSC cis rs8044995 0.563 rs7500163 chr16:68364358 C/G cg09835421 chr16:68378352 PRMT7 -0.74 -8.26 -0.41 3.48e-15 Schizophrenia; LUSC cis rs11264213 0.901 rs72661631 chr1:36417453 A/G cg27506609 chr1:36549197 TEKT2 0.7 7.98 0.4 2.39e-14 Schizophrenia; LUSC cis rs3815700 1.000 rs8113165 chr19:33096316 C/T cg02997394 chr19:33096574 ANKRD27 0.87 10.0 0.48 9.16e-21 Eosinophilic esophagitis; LUSC cis rs67478160 0.584 rs12433009 chr14:104196405 C/G cg08213375 chr14:104286397 PPP1R13B 0.44 8.36 0.42 1.7e-15 Schizophrenia; LUSC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs3740713 1.000 rs12289603 chr11:18471370 T/C cg15463284 chr11:18477534 LDHAL6A -0.49 -5.79 -0.3 1.6e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs11098499 0.754 rs9999724 chr4:120239944 C/T cg24375607 chr4:120327624 NA 0.76 12.15 0.55 2.25e-28 Corneal astigmatism; LUSC cis rs8040855 0.756 rs12909477 chr15:85689875 C/A cg04831495 chr15:85060580 GOLGA6L5 0.39 5.8 0.3 1.54e-8 Bulimia nervosa; LUSC cis rs12541635 0.966 rs11782609 chr8:106967919 G/A cg10147462 chr8:107024639 NA 0.56 9.76 0.47 5.99e-20 Age of smoking initiation; LUSC cis rs79349575 0.811 rs1057897 chr17:47005509 T/G cg22482690 chr17:47019901 SNF8 0.38 7.28 0.37 2.4e-12 Type 2 diabetes; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg20119798 chr7:94954144 PON1 0.36 7.01 0.36 1.31e-11 Paraoxonase activity; LUSC cis rs4589502 1.000 rs8023363 chr15:67154654 G/A cg09911534 chr15:67153556 NA -0.63 -7.29 -0.37 2.3e-12 Lung cancer (smoking interaction); LUSC cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg07606381 chr6:8435919 SLC35B3 0.72 12.03 0.55 6.29e-28 Motion sickness; LUSC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg12311346 chr5:56204834 C5orf35 -0.89 -12.79 -0.57 9.15e-31 Initial pursuit acceleration; LUSC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg22875332 chr1:76189707 ACADM 0.85 15.92 0.66 7.31e-43 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1355223 0.583 rs2941060 chr11:34879154 G/A cg11058730 chr11:34937778 PDHX;APIP 0.67 10.6 0.5 7.78e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg08704250 chr15:31115839 NA 0.58 9.4 0.46 9.12e-19 Huntington's disease progression; LUSC cis rs6574644 1.000 rs6574644 chr14:81778644 G/A cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.68 10.48 0.5 2.1e-22 Monocyte percentage of white cells; LUSC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.76 -0.3 1.88e-8 Total body bone mineral density; LUSC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg14343924 chr8:8086146 FLJ10661 0.41 5.94 0.31 7.35e-9 Mood instability; LUSC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC trans rs7647973 0.626 rs35129566 chr3:49866584 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.63 7.47 0.38 7.28e-13 Menarche (age at onset); LUSC cis rs7726839 0.574 rs72707007 chr5:661856 T/C cg16447950 chr5:562315 NA -0.55 -6.93 -0.35 2.12e-11 Obesity-related traits; LUSC cis rs6076065 0.723 rs2424532 chr20:23373877 G/A cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg24690094 chr11:67383802 NA 0.38 7.28 0.37 2.48e-12 Mean corpuscular volume; LUSC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg11941060 chr3:133502564 NA -0.6 -9.48 -0.46 5.06e-19 Iron status biomarkers; LUSC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg01368799 chr11:117014884 PAFAH1B2 0.5 6.05 0.31 3.83e-9 Blood protein levels; LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.53 -0.34 2.44e-10 Bipolar disorder and schizophrenia; LUSC cis rs35146811 0.735 rs1061230 chr7:99807265 G/A cg13334819 chr7:99746414 C7orf59 0.5 6.73 0.35 7.37e-11 Coronary artery disease; LUSC trans rs1998174 0.509 rs6683945 chr1:171840264 G/A cg13482142 chr2:234261155 NA 0.42 6.11 0.32 2.81e-9 Platelet distribution width; LUSC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg16624210 chr5:671434 TPPP 0.49 6.1 0.32 2.89e-9 Lung disease severity in cystic fibrosis; LUSC cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 5.86 0.31 1.12e-8 Personality dimensions; LUSC cis rs7408868 1.000 rs8107180 chr19:15275430 T/C cg14696996 chr19:15285081 NOTCH3 1.02 9.38 0.46 1.03e-18 Pulse pressure; LUSC cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.41 6.08 0.32 3.37e-9 Rheumatoid arthritis; LUSC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg21643547 chr1:205240462 TMCC2 -0.49 -9.16 -0.45 5.24e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7553864 0.667 rs1886633 chr1:87610356 G/A cg17420885 chr1:87600446 LOC339524 -0.5 -6.91 -0.35 2.52e-11 Smoking behavior; LUSC cis rs4953318 0.619 rs10183887 chr2:46361808 T/A cg12428440 chr2:46370979 PRKCE 0.46 7.73 0.39 1.29e-13 Red blood cell count;Hematocrit;Red blood cell traits; LUSC trans rs4332037 0.539 rs56305291 chr7:2048706 A/G cg11693508 chr17:37793320 STARD3 0.56 6.67 0.34 1.04e-10 Bipolar disorder; LUSC cis rs3809566 0.637 rs8026047 chr15:63323347 C/G cg00520135 chr15:63333846 TPM1 0.33 6.13 0.32 2.46e-9 Platelet count; LUSC cis rs7937682 0.921 rs10789841 chr11:111469582 T/C cg11344533 chr11:111475393 SIK2 0.45 5.91 0.31 8.68e-9 Primary sclerosing cholangitis; LUSC cis rs4588572 0.644 rs891150 chr5:77761794 G/A cg11547950 chr5:77652471 NA -0.48 -7.01 -0.36 1.29e-11 Triglycerides; LUSC cis rs2430307 0.556 rs3930019 chr7:76541610 C/T cg15770687 chr7:76625569 PMS2L11 0.8 8.49 0.42 6.91e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs2908197 0.806 rs6465098 chr7:75972947 T/C cg10167463 chr7:75959203 YWHAG -0.43 -6.41 -0.33 4.87e-10 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs3008870 1.000 rs12137403 chr1:67437043 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.91 -14.76 -0.63 2.6e-38 Lymphocyte percentage of white cells; LUSC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg06363034 chr20:62225388 GMEB2 -0.46 -7.7 -0.39 1.55e-13 Glioblastoma; LUSC cis rs67478160 0.609 rs6576003 chr14:104291330 C/A cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.39 -0.46 9.35e-19 Schizophrenia; LUSC cis rs1878931 0.567 rs7196196 chr16:3411855 C/A cg00484396 chr16:3507460 NAT15 -0.38 -6.39 -0.33 5.47e-10 Body mass index (adult); LUSC cis rs1451375 1.000 rs921451 chr7:50623285 A/G cg18232548 chr7:50535776 DDC 0.5 7.69 0.39 1.66e-13 Malaria; LUSC cis rs1506636 1.000 rs7357252 chr7:123369856 C/T cg03229431 chr7:123269106 ASB15 -0.65 -10.57 -0.5 9.99e-23 Plateletcrit;Platelet count; LUSC cis rs11676348 0.808 rs61700947 chr2:219046171 C/G cg20019365 chr2:219134978 PNKD;AAMP 0.38 5.86 0.31 1.13e-8 Ulcerative colitis; LUSC trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg09436375 chr6:42928200 GNMT -0.29 -6.73 -0.35 7.57e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg21963583 chr11:68658836 MRPL21 0.56 8.29 0.41 2.71e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs354225 0.544 rs10183867 chr2:54812722 C/G cg01766943 chr2:54829624 SPTBN1 0.49 8.06 0.4 1.39e-14 Schizophrenia; LUSC cis rs8060686 0.516 rs7187202 chr16:68273895 T/C cg05110241 chr16:68378359 PRMT7 -0.53 -6.55 -0.34 2.19e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg17294928 chr15:75287854 SCAMP5 0.43 6.21 0.32 1.57e-9 Breast cancer; LUSC trans rs7181230 0.885 rs35781999 chr15:40355406 G/C cg22705835 chr10:65332833 REEP3 -0.4 -6.43 -0.33 4.46e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs56283067 0.847 rs62435999 chr6:44695273 T/G cg20913747 chr6:44695427 NA -0.48 -7.73 -0.39 1.24e-13 Total body bone mineral density; LUSC trans rs1245541 0.508 rs748035 chr10:73833355 C/T cg01042749 chr10:102672582 FAM178A -0.46 -6.1 -0.32 2.87e-9 Insulin-like growth factors; LUSC cis rs16912285 0.585 rs11027807 chr11:24346556 G/T ch.11.24196551F chr11:24239977 NA 0.87 8.38 0.42 1.5e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.25 0.41 3.71e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg20608306 chr11:116969690 SIK3 0.35 6.63 0.34 1.39e-10 Blood protein levels; LUSC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg02822958 chr2:46747628 ATP6V1E2 0.42 6.65 0.34 1.19e-10 Height; LUSC trans rs7939886 0.920 rs11227222 chr11:55876393 G/T cg15704280 chr7:45808275 SEPT13 -0.77 -6.69 -0.34 9.49e-11 Myopia (pathological); LUSC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg08270630 chr22:50330655 NA -0.43 -6.42 -0.33 4.8e-10 Schizophrenia; LUSC cis rs7914558 0.646 rs11191459 chr10:104662118 G/A cg05855489 chr10:104503620 C10orf26 0.42 5.74 0.3 2.12e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.41 -0.33 4.92e-10 Menopause (age at onset); LUSC cis rs7712401 0.601 rs246287 chr5:122245426 A/T cg19077854 chr5:122220652 SNX24 0.4 8.85 0.44 5.38e-17 Mean platelet volume; LUSC cis rs11039100 1.000 rs61875914 chr11:5828299 T/G cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs921968 0.643 rs526134 chr2:219402371 G/A cg02176678 chr2:219576539 TTLL4 0.64 11.79 0.54 4.45e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs13256369 0.755 rs11776987 chr8:8559401 C/G cg18904891 chr8:8559673 CLDN23 0.6 7.87 0.4 4.84e-14 Obesity-related traits; LUSC cis rs763121 0.819 rs138700 chr22:39129999 A/G cg06022373 chr22:39101656 GTPBP1 0.74 11.51 0.53 4.67e-26 Menopause (age at onset); LUSC cis rs11630290 0.649 rs1036910 chr15:64157015 T/C cg12036633 chr15:63758958 NA 0.53 6.83 0.35 4.13e-11 Iris characteristics; LUSC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg04546413 chr19:29218101 NA 0.61 8.07 0.4 1.24e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9309473 0.615 rs62151562 chr2:73603540 T/G cg20560298 chr2:73613845 ALMS1 -0.52 -6.19 -0.32 1.8e-9 Metabolite levels; LUSC cis rs72960926 0.744 rs16884624 chr6:74998293 G/C cg03266952 chr6:74778945 NA -0.63 -5.96 -0.31 6.54e-9 Metabolite levels (MHPG); LUSC cis rs72781680 1.000 rs72798418 chr2:24188922 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs7927771 0.524 rs1056387 chr11:47681370 A/C cg20307385 chr11:47447363 PSMC3 0.5 6.85 0.35 3.59e-11 Subjective well-being; LUSC trans rs6582630 0.519 rs1607882 chr12:38361657 G/A cg06521331 chr12:34319734 NA -0.41 -6.42 -0.33 4.79e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg20818283 chr2:191399100 TMEM194B 0.43 6.72 0.35 7.81e-11 Pulse pressure; LUSC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg06740227 chr12:86229804 RASSF9 0.44 7.07 0.36 8.95e-12 Major depressive disorder; LUSC cis rs9650657 0.707 rs11250076 chr8:10647823 A/G cg27411982 chr8:10470053 RP1L1 -0.44 -7.09 -0.36 8.15e-12 Neuroticism; LUSC cis rs2286885 1.000 rs4837093 chr9:129254443 G/A cg15282417 chr9:129245246 FAM125B 0.42 7.01 0.36 1.35e-11 Intraocular pressure; LUSC cis rs6831352 0.879 rs35146617 chr4:100066686 C/T cg13256891 chr4:100009986 ADH5 -0.5 -6.45 -0.33 4.01e-10 Alcohol dependence; LUSC cis rs858239 0.539 rs6971673 chr7:23159523 C/G cg23682824 chr7:23144976 KLHL7 0.39 5.68 0.3 2.92e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs2124969 0.562 rs13393480 chr2:161058790 G/T cg03641300 chr2:160917029 PLA2R1 -0.44 -7.02 -0.36 1.21e-11 Waist circumference adjusted for body mass index; LUSC trans rs4252134 0.959 rs4252090 chr6:161133544 A/T cg00639886 chr12:54943102 PDE1B -0.43 -6.21 -0.32 1.6e-9 Giant cell arteritis; LUSC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg06074448 chr4:187884817 NA -0.41 -6.82 -0.35 4.28e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.836 rs765731 chr8:11121498 T/A cg21775007 chr8:11205619 TDH -0.61 -9.48 -0.46 4.95e-19 Retinal vascular caliber; LUSC cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 0.882 rs10407933 chr19:19364319 A/G cg11584989 chr19:19387371 SF4 0.61 7.27 0.37 2.54e-12 Bipolar disorder; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg14668821 chr17:77704760 ENPP7 0.29 6.03 0.31 4.41e-9 Menopause (age at onset); LUSC cis rs5769707 0.521 rs6009810 chr22:50059540 A/G cg20744362 chr22:50050164 C22orf34 0.37 6.85 0.35 3.59e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9297145 0.565 rs6952161 chr7:98733337 A/G cg05967295 chr7:98741636 SMURF1 0.65 10.35 0.49 5.97e-22 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs4919694 0.611 rs7091462 chr10:104948615 C/T cg05855489 chr10:104503620 C10orf26 0.56 6.45 0.33 4.02e-10 Arsenic metabolism; LUSC cis rs12477438 0.520 rs13031919 chr2:99848932 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.53 0.53 4.12e-26 Chronic sinus infection; LUSC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg10802521 chr3:52805072 NEK4 -0.44 -6.84 -0.35 3.86e-11 Electroencephalogram traits; LUSC cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.64 0.39 2.3e-13 Lung function (FEV1/FVC); LUSC cis rs7618501 1.000 rs7634902 chr3:49762662 G/T cg13072238 chr3:49761600 GMPPB -0.4 -6.44 -0.33 4.19e-10 Intelligence (multi-trait analysis); LUSC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg18512352 chr11:47633146 NA -0.48 -9.56 -0.46 2.61e-19 Subjective well-being; LUSC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.63e-8 Parkinson's disease; LUSC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg22800045 chr5:56110881 MAP3K1 -0.64 -8.92 -0.44 3.12e-17 Initial pursuit acceleration; LUSC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.12 -0.48 3.71e-21 Developmental language disorder (linguistic errors); LUSC cis rs478304 0.654 rs10896029 chr11:65452952 C/T cg27068330 chr11:65405492 SIPA1 -0.74 -10.3 -0.49 8.46e-22 Acne (severe); LUSC cis rs73200209 0.701 rs11609930 chr12:116644670 A/G cg01776926 chr12:116560359 MED13L -0.5 -6.12 -0.32 2.63e-9 Total body bone mineral density; LUSC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg00745463 chr17:30367425 LRRC37B -0.85 -9.92 -0.48 1.75e-20 Hip circumference adjusted for BMI; LUSC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg12288994 chr5:1860383 NA 0.32 7.05 0.36 1.04e-11 Cardiovascular disease risk factors; LUSC cis rs2898290 0.622 rs978803 chr8:11343475 C/T cg27411982 chr8:10470053 RP1L1 0.42 7.05 0.36 1e-11 Systolic blood pressure; LUSC cis rs3768617 0.510 rs1886501 chr1:183095234 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg24675658 chr1:53192096 ZYG11B -0.54 -8.39 -0.42 1.38e-15 Monocyte count; LUSC cis rs1348850 0.567 rs880899 chr2:178532416 A/G cg22681709 chr2:178499509 PDE11A -0.55 -10.98 -0.52 3.63e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg14440974 chr22:39074834 NA -0.37 -6.14 -0.32 2.34e-9 Menopause (age at onset); LUSC cis rs868036 0.718 rs2241420 chr15:68082816 G/A cg24579218 chr15:68104479 NA -0.37 -6.58 -0.34 1.79e-10 Restless legs syndrome; LUSC cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06022373 chr22:39101656 GTPBP1 0.71 11.1 0.52 1.35e-24 Menopause (age at onset); LUSC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg16624210 chr5:671434 TPPP 0.49 6.39 0.33 5.59e-10 Obesity-related traits; LUSC cis rs4363385 0.510 rs2339386 chr1:152892307 C/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.11 -0.32 2.74e-9 Inflammatory skin disease; LUSC cis rs2625529 0.668 rs12591313 chr15:72556746 T/C cg16672083 chr15:72433130 SENP8 -0.49 -7.2 -0.37 4.02e-12 Red blood cell count; LUSC cis rs7903847 0.642 rs61863819 chr10:99142400 T/C cg20016023 chr10:99160130 RRP12 -0.35 -8.3 -0.41 2.63e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg05253716 chr12:129299332 SLC15A4;MGC16384 -0.43 -5.69 -0.3 2.72e-8 Systemic lupus erythematosus; LUSC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.06 15.61 0.65 1.2e-41 Age-related macular degeneration (geographic atrophy); LUSC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg24250549 chr1:154909240 PMVK 0.65 10.87 0.51 9.05e-24 Prostate cancer; LUSC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg23172400 chr8:95962367 TP53INP1 -0.37 -7.4 -0.38 1.14e-12 Type 2 diabetes; LUSC cis rs7223966 0.921 rs67018565 chr17:61928055 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.76 0.35 6.35e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs3820928 0.874 rs10933165 chr2:227883648 C/G cg11843606 chr2:227700838 RHBDD1 0.54 7.98 0.4 2.33e-14 Pulmonary function; LUSC trans rs7824557 0.815 rs958648 chr8:11103895 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.23 -0.32 1.39e-9 Retinal vascular caliber; LUSC cis rs2688608 1.000 rs2688610 chr10:75654931 A/G cg19442545 chr10:75533431 FUT11 0.37 5.74 0.3 2.07e-8 Inflammatory bowel disease; LUSC trans rs11250097 0.549 rs11784897 chr8:11310442 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -7.13 -0.36 6.31e-12 Neuroticism; LUSC cis rs4930103 0.711 rs217710 chr11:2007244 C/T cg23202291 chr11:1979235 NA 0.41 6.2 0.32 1.69e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs12310956 0.532 rs6488187 chr12:33975029 C/T cg26384229 chr12:38710491 ALG10B 0.67 10.52 0.5 1.54e-22 Morning vs. evening chronotype; LUSC cis rs10203711 0.966 rs7594129 chr2:239600686 G/T cg14580085 chr2:239553406 NA 0.43 7.35 0.37 1.5e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.07 0.44 1.03e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs2219968 0.962 rs4276683 chr8:78939763 T/G cg00738934 chr8:78996279 NA 0.4 7.15 0.36 5.57e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1483121 0.808 rs11039482 chr11:48009074 C/T cg20307385 chr11:47447363 PSMC3 0.65 5.74 0.3 2.1e-8 Fasting blood glucose (BMI interaction);Fasting blood glucose; LUSC cis rs7098414 0.511 rs10887826 chr10:82151380 C/T cg01528321 chr10:82214614 TSPAN14 0.6 9.02 0.44 1.51e-17 Post bronchodilator FEV1; LUSC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg12963246 chr6:28129442 ZNF389 0.48 6.73 0.35 7.46e-11 Depression; LUSC cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.72 10.84 0.51 1.21e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg16339924 chr4:17578868 LAP3 0.49 7.09 0.36 8.13e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7000551 0.689 rs2122878 chr8:22311916 T/C cg12081754 chr8:22256438 SLC39A14 0.48 7.29 0.37 2.33e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg15103426 chr22:29168792 CCDC117 -0.5 -6.24 -0.32 1.32e-9 Lymphocyte counts; LUSC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg02487422 chr3:49467188 NICN1 0.45 7.17 0.37 4.78e-12 Resting heart rate; LUSC cis rs2708377 0.929 rs61931280 chr12:11300255 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs739401 0.611 rs401707 chr11:3050965 T/C cg08508325 chr11:3079039 CARS -0.53 -13.31 -0.59 1.01e-32 Longevity; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg04124316 chr13:42615242 NA 0.42 6.22 0.32 1.5e-9 N-glycan levels; LUSC cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg00071950 chr4:10020882 SLC2A9 -0.57 -9.73 -0.47 7.51e-20 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg21918786 chr6:109611834 NA -0.35 -6.02 -0.31 4.59e-9 Reticulocyte fraction of red cells; LUSC cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14240646 chr10:27532245 ACBD5 0.65 7.49 0.38 6.41e-13 Breast cancer; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg23102388 chr7:1867652 MAD1L1 -0.32 -5.81 -0.3 1.5e-8 Bipolar disorder and schizophrenia; LUSC cis rs983392 0.667 rs583791 chr11:59947252 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.41 0.33 4.87e-10 Alzheimer's disease (late onset); LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.29 0.76 3.71e-64 Prudent dietary pattern; LUSC trans rs11098499 0.866 rs72676074 chr4:120359841 A/C cg25214090 chr10:38739885 LOC399744 0.54 7.88 0.4 4.8e-14 Corneal astigmatism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05749855 chr16:89472771 ANKRD11 -0.84 -7.79 -0.39 8.73e-14 Cognitive performance; LUSC cis rs9346649 0.654 rs35453512 chr6:168491906 C/G cg02770688 chr6:168491649 NA 0.47 8.96 0.44 2.32e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg11764359 chr7:65958608 NA -0.53 -6.93 -0.35 2.22e-11 Aortic root size; LUSC trans rs637571 0.522 rs550435 chr11:65732651 G/A cg17712092 chr4:129076599 LARP1B 0.72 10.91 0.51 6.36e-24 Eosinophil percentage of white cells; LUSC trans rs12310956 0.532 rs10506119 chr12:33963684 A/G cg26384229 chr12:38710491 ALG10B 0.75 11.9 0.55 1.83e-27 Morning vs. evening chronotype; LUSC cis rs6752107 0.967 rs11694081 chr2:234148586 A/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 10.76 0.51 2.28e-23 Crohn's disease;Inflammatory bowel disease; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg03461704 chr1:205818484 PM20D1 0.39 6.54 0.34 2.29e-10 Menarche (age at onset); LUSC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 -0.38 -5.8 -0.3 1.57e-8 Platelet count; LUSC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg25258033 chr6:167368657 RNASET2 0.39 6.27 0.32 1.09e-9 Crohn's disease; LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.74 -0.57 1.37e-30 Alzheimer's disease; LUSC trans rs7395662 0.525 rs4882060 chr11:48441874 G/C cg21153622 chr11:89784906 NA -0.39 -6.04 -0.31 4.16e-9 HDL cholesterol; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6494488 0.500 rs111737146 chr15:65004840 C/T cg08069370 chr15:64387884 SNX1 -0.66 -5.77 -0.3 1.76e-8 Coronary artery disease; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.6 0.54 2.33e-26 Prudent dietary pattern; LUSC cis rs4629180 0.675 rs10195061 chr2:102093974 T/G cg01388757 chr2:102091195 RFX8 -0.36 -6.13 -0.32 2.43e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 11.04 0.52 2.33e-24 Platelet count; LUSC trans rs7937682 0.921 rs4616071 chr11:111440865 C/G cg18187862 chr3:45730750 SACM1L -0.49 -6.02 -0.31 4.71e-9 Primary sclerosing cholangitis; LUSC cis rs9517320 0.534 rs9554478 chr13:99187792 G/A cg20487152 chr13:99095054 FARP1 -0.41 -6.89 -0.35 2.87e-11 Longevity; LUSC cis rs9300255 0.537 rs2682429 chr12:123642955 C/G cg00376283 chr12:123451042 ABCB9 0.67 8.44 0.42 9.73e-16 Neutrophil percentage of white cells; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg24060327 chr5:131705240 SLC22A5 -0.39 -6.46 -0.33 3.63e-10 Blood metabolite levels; LUSC cis rs1577917 0.958 rs1447160 chr6:86546123 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.99 -0.44 1.88e-17 Response to antipsychotic treatment; LUSC cis rs8060686 0.545 rs7199878 chr16:68186301 A/G cg05110241 chr16:68378359 PRMT7 -0.63 -6.81 -0.35 4.42e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs617219 0.817 rs72764978 chr5:78491840 T/A cg24856658 chr5:78533917 JMY -0.3 -5.86 -0.31 1.13e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg19468946 chr17:37922297 IKZF3 -0.39 -6.17 -0.32 1.98e-9 Self-reported allergy; LUSC trans rs9929218 0.817 rs3118228 chr16:68710737 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.88 -13.65 -0.6 5.33e-34 Colorectal cancer; LUSC cis rs2625529 0.668 rs35206011 chr15:72539494 T/C cg16672083 chr15:72433130 SENP8 -0.49 -7.25 -0.37 2.89e-12 Red blood cell count; LUSC cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.02 -0.4 1.81e-14 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs9311676 0.609 rs55845662 chr3:58424899 A/C cg13750441 chr3:58318267 PXK 0.35 6.73 0.35 7.53e-11 Systemic lupus erythematosus; LUSC trans rs7819412 0.540 rs2409726 chr8:11043138 T/C cg15556689 chr8:8085844 FLJ10661 -0.5 -7.02 -0.36 1.25e-11 Triglycerides; LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg24813613 chr7:1882135 MAD1L1 -0.43 -7.47 -0.38 7.07e-13 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs17685 0.735 rs11763339 chr7:75761541 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.6 -0.38 3.04e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4689388 0.890 rs4689397 chr4:6299387 G/A cg14416269 chr4:6271139 WFS1 0.54 11.41 0.53 1.07e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7927592 0.913 rs7123564 chr11:68362164 C/T cg16797656 chr11:68205561 LRP5 0.38 6.16 0.32 2.14e-9 Total body bone mineral density; LUSC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg20406979 chr6:167373233 NA 0.26 6.22 0.32 1.48e-9 Crohn's disease; LUSC cis rs958025 1 rs958025 chr15:78759348 C/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.92 -0.31 7.82e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs11123259 0.830 rs6733911 chr2:115694295 G/C cg00844339 chr9:138873417 NA 0.31 6.09 0.32 3.18e-9 Gut microbiome composition (winter); LUSC cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg06627557 chr7:32535165 LSM5;AVL9 -1.07 -20.88 -0.75 1.59e-62 Cognitive ability; LUSC trans rs6480314 0.542 rs79081413 chr10:70028503 A/G cg04882175 chr6:131122610 NA -0.53 -6.27 -0.32 1.09e-9 Optic nerve measurement (disc area); LUSC cis rs7605827 0.897 rs7586068 chr2:15596747 T/A cg19274914 chr2:15703543 NA 0.47 8.98 0.44 2.02e-17 Educational attainment (years of education); LUSC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.21 0.32 1.54e-9 Menopause (age at onset); LUSC cis rs6012953 0.934 rs2904269 chr20:49156331 C/A cg13958625 chr20:49123093 NA 0.3 6.69 0.34 9.65e-11 Vitiligo; LUSC cis rs1865760 1.000 rs3799372 chr6:25922311 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.82 0.35 4.38e-11 Height; LUSC cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -9.07 -0.44 1.08e-17 Breast cancer; LUSC cis rs12220238 1.000 rs2279648 chr10:75867193 G/T cg19889307 chr10:75911429 ADK;AP3M1 0.67 7.62 0.38 2.65e-13 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9443645 0.527 rs7756996 chr6:79509367 A/C cg23262351 chr6:79576851 IRAK1BP1 -0.41 -6.12 -0.32 2.6e-9 Intelligence (multi-trait analysis); LUSC cis rs2486288 0.656 rs11631021 chr15:45556829 A/G cg04036182 chr15:45458818 NA -0.36 -5.94 -0.31 7.11e-9 Glomerular filtration rate; LUSC cis rs701145 0.586 rs181443 chr3:153959028 G/T cg17054900 chr3:154042577 DHX36 0.46 6.06 0.31 3.63e-9 Coronary artery disease; LUSC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg05872129 chr22:39784769 NA -0.61 -11.3 -0.53 2.64e-25 Intelligence (multi-trait analysis); LUSC cis rs11958404 1.000 rs72816532 chr5:157413130 C/T cg05962755 chr5:157440814 NA 0.51 6.24 0.32 1.31e-9 IgG glycosylation; LUSC cis rs599083 0.793 rs314750 chr11:68182028 G/A cg20283391 chr11:68216788 NA 0.5 6.68 0.34 9.83e-11 Bone mineral density (spine); LUSC cis rs734999 0.566 rs12748729 chr1:2558740 C/T cg18854424 chr1:2615690 NA -0.5 -10.01 -0.48 8.46e-21 Ulcerative colitis; LUSC cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.78 8.11 0.41 9.99e-15 Initial pursuit acceleration; LUSC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg13206674 chr6:150067644 NUP43 0.62 10.05 0.48 6.22e-21 Lung cancer; LUSC cis rs9467773 1.000 rs9393729 chr6:26514166 C/T cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.52e-42 Intelligence (multi-trait analysis); LUSC cis rs62400317 0.859 rs12212745 chr6:45166258 C/T cg20913747 chr6:44695427 NA -0.47 -7.5 -0.38 5.86e-13 Total body bone mineral density; LUSC cis rs4319547 0.695 rs55834409 chr12:122862560 C/G cg05707623 chr12:122985044 ZCCHC8 0.66 8.11 0.41 9.63e-15 Body mass index; LUSC cis rs2040771 0.770 rs2518840 chr22:19255856 A/C cg02655711 chr22:19163373 SLC25A1 0.49 8.8 0.43 7.41e-17 Metabolite levels (small molecules and protein measures); LUSC cis rs1670533 0.932 rs13106586 chr4:1054182 G/A cg27284194 chr4:1044797 NA 0.59 8.84 0.44 5.65e-17 Recombination rate (females); LUSC cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg16586182 chr3:47516702 SCAP 0.53 8.31 0.41 2.4e-15 Colorectal cancer; LUSC cis rs9300255 0.739 rs10846491 chr12:123753492 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -5.9 -0.31 8.99e-9 Neutrophil percentage of white cells; LUSC trans rs75804782 0.641 rs1030786 chr2:239361150 A/G cg01134436 chr17:81009848 B3GNTL1 0.64 6.17 0.32 1.93e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs8060686 0.516 rs8048365 chr16:68253326 T/A cg05110241 chr16:68378359 PRMT7 -0.46 -5.95 -0.31 6.6e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg05340658 chr4:99064831 C4orf37 0.64 11.1 0.52 1.42e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs7937682 0.855 rs11213985 chr11:111581521 C/A cg18187862 chr3:45730750 SACM1L 0.57 7.42 0.38 9.59e-13 Primary sclerosing cholangitis; LUSC cis rs2692947 0.832 rs2692954 chr2:96683378 T/G cg23100626 chr2:96804247 ASTL 0.31 7.36 0.37 1.42e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4148883 0.629 rs2602899 chr4:100010128 C/T cg12011299 chr4:100065546 ADH4 0.49 8.05 0.4 1.47e-14 Alcohol dependence; LUSC cis rs6545883 0.630 rs12998475 chr2:61437487 T/C cg15711740 chr2:61764176 XPO1 0.42 6.3 0.33 9.6e-10 Tuberculosis; LUSC cis rs9549260 0.755 rs7317254 chr13:41217849 A/G cg21288729 chr13:41239152 FOXO1 0.66 10.17 0.49 2.4e-21 Red blood cell count; LUSC cis rs4906332 0.901 rs4900575 chr14:103899169 G/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.46e-12 Coronary artery disease; LUSC cis rs2806561 0.734 rs1952527 chr1:23400969 T/C cg12483005 chr1:23474871 LUZP1 0.39 5.75 0.3 2.03e-8 Height; LUSC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg14784868 chr12:69753453 YEATS4 0.88 15.63 0.65 1.05e-41 Cerebrospinal fluid biomarker levels; LUSC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg12963246 chr6:28129442 ZNF389 0.48 7.12 0.36 6.68e-12 Parkinson's disease; LUSC cis rs3755132 0.778 rs4668455 chr2:15740177 G/A cg12888861 chr2:15731646 DDX1 0.49 7.16 0.36 5.19e-12 Wilms tumor; LUSC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg05802129 chr4:122689817 NA -0.45 -7.32 -0.37 1.83e-12 Type 2 diabetes; LUSC cis rs881375 0.678 rs7037195 chr9:123684000 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 6.06 0.31 3.73e-9 Rheumatoid arthritis; LUSC trans rs330071 0.500 rs17662123 chr8:9246837 G/A cg06636001 chr8:8085503 FLJ10661 0.52 8.03 0.4 1.69e-14 Acne (severe); LUSC cis rs41271473 0.950 rs72750042 chr1:228854138 T/C cg16512390 chr1:228756714 NA 0.55 6.5 0.34 2.89e-10 Chronic lymphocytic leukemia; LUSC cis rs9875589 0.509 rs9836573 chr3:14065239 G/A cg19554555 chr3:13937349 NA -0.38 -5.71 -0.3 2.47e-8 Ovarian reserve; LUSC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg11062466 chr8:58055876 NA 0.56 7.36 0.37 1.48e-12 Developmental language disorder (linguistic errors); LUSC cis rs2273669 0.504 rs78123955 chr6:109434847 T/C cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs11958404 0.932 rs72818108 chr5:157437883 A/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7903847 0.692 rs7900255 chr10:99157575 G/A cg08345082 chr10:99160200 RRP12 -0.35 -7.03 -0.36 1.16e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs59698941 0.943 rs12516596 chr5:132273608 C/G cg02081065 chr5:132209139 LEAP2 -0.62 -6.22 -0.32 1.45e-9 Apolipoprotein A-IV levels; LUSC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.64 9.83 0.47 3.45e-20 Lymphocyte counts; LUSC cis rs80282103 0.571 rs56183119 chr10:1068370 C/T cg08668510 chr10:1095578 IDI1 0.63 6.04 0.31 4.07e-9 Glomerular filtration rate (creatinine); LUSC trans rs7219451 0.655 rs8067028 chr17:38974029 G/A cg11917579 chr10:2815429 NA 0.28 6.09 0.32 3.15e-9 Glucose homeostasis traits; LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg10523679 chr1:76189770 ACADM -0.53 -7.98 -0.4 2.44e-14 Daytime sleep phenotypes; LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.17 0.41 6.44e-15 Prudent dietary pattern; LUSC cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.84 -0.35 3.77e-11 Monocyte percentage of white cells; LUSC cis rs453301 0.562 rs1038248 chr8:9040858 G/T cg15556689 chr8:8085844 FLJ10661 -0.42 -6.44 -0.33 4.14e-10 Joint mobility (Beighton score); LUSC cis rs7769051 0.522 rs62424539 chr6:133173272 C/T cg22852734 chr6:133119734 C6orf192 0.79 6.31 0.33 8.66e-10 Type 2 diabetes nephropathy; LUSC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg17724175 chr1:150552817 MCL1 -0.46 -8.1 -0.41 1.02e-14 Urate levels; LUSC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg07424592 chr7:64974309 NA 0.7 6.18 0.32 1.89e-9 Diabetic kidney disease; LUSC cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg26647111 chr11:31128758 NA -0.43 -6.22 -0.32 1.48e-9 Red blood cell count; LUSC cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg23093090 chr10:104574429 C10orf26 -0.37 -6.86 -0.35 3.32e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7914558 0.966 rs12571568 chr10:104891396 C/G cg05855489 chr10:104503620 C10orf26 0.6 9.68 0.47 1.1e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg13206674 chr6:150067644 NUP43 0.56 8.73 0.43 1.2e-16 Lung cancer; LUSC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg17971929 chr21:40555470 PSMG1 -0.68 -11.28 -0.53 3.31e-25 Cognitive function; LUSC cis rs1267303 0.637 rs1745371 chr1:46985192 C/T cg25110126 chr1:46999211 NA 0.53 7.27 0.37 2.56e-12 Monobrow; LUSC cis rs12421382 0.690 rs2716049 chr11:109609889 A/C cg27471124 chr11:109292789 C11orf87 0.42 7.5 0.38 5.67e-13 Schizophrenia; LUSC cis rs1801251 1.000 rs7558609 chr2:233700379 C/T cg08000102 chr2:233561755 GIGYF2 0.66 10.89 0.51 7.79e-24 Coronary artery disease; LUSC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg13206674 chr6:150067644 NUP43 0.57 8.93 0.44 2.81e-17 Lung cancer; LUSC cis rs599083 0.590 rs661988 chr11:68189251 T/G cg16797656 chr11:68205561 LRP5 0.42 5.78 0.3 1.72e-8 Bone mineral density (spine); LUSC cis rs6433857 0.536 rs1542035 chr2:181351114 T/C cg23363182 chr2:181467187 NA -0.45 -7.29 -0.37 2.2e-12 Body mass index; LUSC cis rs2404602 0.647 rs12910820 chr15:77022825 T/C cg23625390 chr15:77176239 SCAPER -0.65 -9.96 -0.48 1.26e-20 Blood metabolite levels; LUSC cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg21535247 chr6:8435926 SLC35B3 0.6 9.37 0.46 1.13e-18 Motion sickness; LUSC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.44 7.52 0.38 5.06e-13 Electroencephalogram traits; LUSC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg18876405 chr7:65276391 NA -0.54 -8.42 -0.42 1.16e-15 Aortic root size; LUSC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.88 0.66 1.04e-42 Platelet count; LUSC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg06697600 chr4:7070879 GRPEL1 -0.41 -6.68 -0.34 9.94e-11 Monocyte percentage of white cells; LUSC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg08798685 chr6:27730294 NA -0.61 -6.21 -0.32 1.61e-9 Breast cancer; LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg00431813 chr7:1051703 C7orf50 -0.45 -7.43 -0.38 9.23e-13 Longevity;Endometriosis; LUSC cis rs11229555 0.645 rs4367960 chr11:58194961 C/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4363385 0.782 rs394859 chr1:153025704 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.48 -0.38 6.58e-13 Inflammatory skin disease; LUSC cis rs9303542 0.625 rs6504340 chr17:46617019 A/G cg09704116 chr17:46666958 LOC404266 0.29 5.75 0.3 2.01e-8 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg22681709 chr2:178499509 PDE11A -0.52 -9.2 -0.45 3.97e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6964587 1.000 rs6968870 chr7:91661111 G/C cg22709100 chr7:91322751 NA 0.4 5.86 0.31 1.12e-8 Breast cancer; LUSC trans rs7937682 0.564 rs11600652 chr11:111754368 A/T cg18187862 chr3:45730750 SACM1L -0.51 -6.18 -0.32 1.83e-9 Primary sclerosing cholangitis; LUSC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg07936489 chr17:37558343 FBXL20 0.7 9.93 0.48 1.56e-20 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg05313129 chr8:58192883 C8orf71 -0.5 -6.92 -0.35 2.28e-11 Developmental language disorder (linguistic errors); LUSC cis rs2346177 0.777 rs7587138 chr2:46657089 A/G cg02822958 chr2:46747628 ATP6V1E2 -0.36 -6.07 -0.32 3.49e-9 HDL cholesterol; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg25767906 chr1:53392781 SCP2 0.48 8.71 0.43 1.47e-16 Monocyte count; LUSC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg20135002 chr11:47629003 NA -0.51 -8.21 -0.41 4.85e-15 Subjective well-being; LUSC cis rs1153858 1.000 rs2453541 chr15:45645378 G/A cg26924012 chr15:45694286 SPATA5L1 1.14 20.41 0.74 1.14e-60 Homoarginine levels; LUSC cis rs1595825 0.891 rs6707521 chr2:198713231 A/G cg00982548 chr2:198649783 BOLL 0.58 7.3 0.37 2.06e-12 Ulcerative colitis; LUSC cis rs6690583 0.623 rs12030730 chr1:85454109 C/G cg11262906 chr1:85462892 MCOLN2 0.67 6.43 0.33 4.48e-10 Serum sulfate level; LUSC trans rs1973993 0.745 rs7512263 chr1:96941158 C/A cg10631902 chr5:14652156 NA -0.53 -7.87 -0.4 4.97e-14 Weight; LUSC cis rs7312933 0.558 rs1796388 chr12:42785987 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.83 -0.35 3.95e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6977660 0.714 rs4721824 chr7:19785898 A/G cg05791153 chr7:19748676 TWISTNB 0.75 7.42 0.38 1.01e-12 Thyroid stimulating hormone; LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4595586 0.545 rs4438082 chr12:39363870 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg21433313 chr16:3507492 NAT15 0.44 5.99 0.31 5.44e-9 Body mass index (adult); LUSC cis rs1775715 0.870 rs3847415 chr10:32219456 G/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.69 0.34 9.42e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg18512352 chr11:47633146 NA -0.46 -9.22 -0.45 3.55e-18 Subjective well-being; LUSC cis rs3849570 0.961 rs3772896 chr3:81751968 C/T cg07356753 chr3:81810745 GBE1 -0.7 -11.15 -0.52 9.31e-25 Waist circumference;Body mass index; LUSC cis rs12410462 0.581 rs12402691 chr1:227543693 G/A cg10327440 chr1:227177885 CDC42BPA -0.67 -6.56 -0.34 2.02e-10 Major depressive disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10524192 chr9:34637478 SIGMAR1 -0.44 -6.68 -0.34 1e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7524258 0.900 rs2412151 chr1:7303216 G/C cg07173049 chr1:7289937 CAMTA1 0.33 6.95 0.36 1.97e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7089973 0.604 rs11196941 chr10:116596258 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.1 0.45 8.28e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6967385 0.583 rs1116972 chr7:12348307 A/C cg20607287 chr7:12443886 VWDE 0.39 5.9 0.31 8.87e-9 Response to taxane treatment (placlitaxel); LUSC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg24110177 chr3:50126178 RBM5 -0.54 -8.8 -0.43 7.39e-17 Intelligence (multi-trait analysis); LUSC cis rs2526882 0.562 rs12893492 chr14:71506775 T/C cg15816911 chr14:71606274 NA 0.34 5.92 0.31 7.92e-9 Schizophrenia; LUSC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg11062466 chr8:58055876 NA 0.59 7.34 0.37 1.65e-12 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg06634786 chr22:41940651 POLR3H -0.55 -6.8 -0.35 4.89e-11 Vitiligo; LUSC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg23262073 chr20:60523788 NA -0.43 -6.2 -0.32 1.69e-9 Body mass index; LUSC cis rs4253772 0.701 rs9627280 chr22:46643964 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.47 6.38 0.33 5.99e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg14552801 chr7:65878734 NA 0.38 5.92 0.31 7.97e-9 Aortic root size; LUSC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs17253792 0.822 rs28549152 chr14:56091239 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs4903214 0.895 rs7161419 chr14:74695757 A/G cg08255017 chr14:74727001 VSX2 -0.41 -5.92 -0.31 7.89e-9 Inflammatory bowel disease; LUSC cis rs3820928 0.967 rs720501 chr2:227778445 C/T cg11843606 chr2:227700838 RHBDD1 -0.55 -7.98 -0.4 2.39e-14 Pulmonary function; LUSC trans rs9951602 0.512 rs1599634 chr18:76643645 T/C cg02800362 chr5:177631904 HNRNPAB 0.83 12.44 0.56 1.95e-29 Obesity-related traits; LUSC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg19812747 chr11:111475976 SIK2 -0.55 -8.18 -0.41 5.92e-15 Primary sclerosing cholangitis; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg16405210 chr4:1374714 KIAA1530 -0.82 -14.11 -0.61 8.92e-36 Longevity; LUSC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg18876405 chr7:65276391 NA 0.68 12.22 0.56 1.26e-28 Aortic root size; LUSC cis rs3806843 1.000 rs3756342 chr5:140165624 G/A cg19875535 chr5:140030758 IK 0.5 8.24 0.41 3.98e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs6545883 0.894 rs2121661 chr2:61561658 A/G cg15711740 chr2:61764176 XPO1 0.43 6.59 0.34 1.76e-10 Tuberculosis; LUSC cis rs992157 0.710 rs12996912 chr2:219110555 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.49 7.69 0.39 1.68e-13 Colorectal cancer; LUSC cis rs7598759 0.548 rs1823328 chr2:232355184 G/A cg19187155 chr2:232395269 NMUR1 0.94 16.34 0.67 1.68e-44 Noise-induced hearing loss; LUSC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg06850241 chr22:41845214 NA -0.31 -5.76 -0.3 1.89e-8 Vitiligo; LUSC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg20476274 chr7:133979776 SLC35B4 0.85 16.12 0.66 1.25e-43 Mean platelet volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27007426 chr8:87354751 WWP1 -0.4 -5.94 -0.31 6.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.44 6.8 0.35 4.96e-11 Schizophrenia; LUSC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg06558623 chr16:89946397 TCF25 1.08 9.74 0.47 6.73e-20 Skin colour saturation; LUSC cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg15848620 chr12:58087721 OS9 0.47 6.53 0.34 2.39e-10 Celiac disease or Rheumatoid arthritis; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg02796970 chr10:39023768 NA 0.51 8.25 0.41 3.82e-15 Menopause (age at onset); LUSC cis rs11779988 0.545 rs438873 chr8:17786516 G/A cg01800426 chr8:17659068 MTUS1 -0.47 -5.8 -0.3 1.53e-8 Breast cancer; LUSC cis rs1461503 0.966 rs4936764 chr11:122844492 G/A cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg03948781 chr1:205179583 DSTYK 0.3 5.65 0.3 3.5e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7264396 0.676 rs58372200 chr20:34555445 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs12681288 0.862 rs2004701 chr8:1022287 A/G cg15309053 chr8:964076 NA 0.3 5.89 0.31 9.29e-9 Schizophrenia; LUSC trans rs9329221 0.662 rs9650650 chr8:10247976 C/T cg15556689 chr8:8085844 FLJ10661 0.63 8.76 0.43 1.02e-16 Neuroticism; LUSC cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg22963979 chr7:1858916 MAD1L1 -0.56 -8.58 -0.43 3.59e-16 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -9.56 -0.46 2.74e-19 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23243902 chr11:117049849 SIDT2 0.42 6.2 0.32 1.7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs60843830 1.000 rs9213 chr2:218386 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.06 0.48 5.93e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.33 0.77 3.16e-68 Prudent dietary pattern; LUSC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg00945038 chr17:61921165 SMARCD2 0.51 8.73 0.43 1.23e-16 Prudent dietary pattern; LUSC trans rs1814175 0.935 rs7479914 chr11:49661351 T/C cg03929089 chr4:120376271 NA -1.0 -18.3 -0.71 2.56e-52 Height; LUSC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg23625390 chr15:77176239 SCAPER 0.46 7.12 0.36 6.79e-12 Blood metabolite levels; LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg00684032 chr4:1343700 KIAA1530 0.35 6.31 0.33 8.82e-10 Obesity-related traits; LUSC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg11189052 chr15:85197271 WDR73 -0.65 -10.15 -0.49 2.83e-21 P wave terminal force; LUSC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg23711669 chr6:146136114 FBXO30 0.93 18.29 0.71 2.79e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs13089785 1.000 rs35181974 chr3:123607884 C/A cg02558132 chr3:123411198 MYLK 0.36 6.13 0.32 2.46e-9 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg12379764 chr21:47803548 PCNT 0.49 7.0 0.36 1.4e-11 Testicular germ cell tumor; LUSC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg19046167 chr17:80928561 B3GNTL1 -0.45 -6.62 -0.34 1.44e-10 Breast cancer; LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.79 0.47 4.58e-20 Bipolar disorder; LUSC cis rs6594499 0.872 rs1379300 chr5:110441439 A/G cg04022379 chr5:110408740 TSLP 0.43 6.5 0.33 2.96e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs62400317 0.859 rs12203558 chr6:45244423 C/G cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs10489202 1.000 rs10489202 chr1:167903079 A/C cg24449463 chr1:168025552 DCAF6 0.56 6.99 0.36 1.5e-11 Schizophrenia; LUSC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg05585544 chr11:47624801 NA -0.34 -6.17 -0.32 1.96e-9 Subjective well-being; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg18758796 chr5:131593413 PDLIM4 0.4 7.06 0.36 9.82e-12 Blood metabolite levels; LUSC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg16423285 chr20:60520624 NA 0.64 8.17 0.41 6.5e-15 Body mass index; LUSC cis rs8017423 0.967 rs11159956 chr14:90715890 C/T cg14092571 chr14:90743983 NA 0.36 5.84 0.3 1.22e-8 Mortality in heart failure; LUSC cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -11.11 -0.52 1.25e-24 Chronic sinus infection; LUSC trans rs8002861 0.967 rs9533689 chr13:44480413 A/C cg12856521 chr11:46389249 DGKZ 0.41 6.38 0.33 6.02e-10 Leprosy; LUSC cis rs9929218 0.953 rs3118235 chr16:68732977 A/G cg02972257 chr16:68554789 NA -0.44 -5.99 -0.31 5.5e-9 Colorectal cancer; LUSC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg13206674 chr6:150067644 NUP43 0.6 9.53 0.46 3.38e-19 Lung cancer; LUSC trans rs561341 0.883 rs1034627 chr17:30219569 C/T cg27661571 chr11:113659931 NA -0.51 -6.24 -0.32 1.34e-9 Hip circumference adjusted for BMI; LUSC cis rs7617773 0.744 rs2125482 chr3:48323133 T/G cg11946769 chr3:48343235 NME6 0.86 13.86 0.6 8.31e-35 Coronary artery disease; LUSC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg21984481 chr17:79567631 NPLOC4 -0.68 -14.44 -0.62 4.54e-37 Eye color traits; LUSC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg03354898 chr7:1950403 MAD1L1 0.38 7.45 0.38 7.87e-13 Bipolar disorder and schizophrenia; LUSC cis rs700651 0.821 rs770661 chr2:198725444 A/G cg00792783 chr2:198669748 PLCL1 0.43 5.68 0.3 2.9e-8 Intracranial aneurysm; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00071408 chr8:22864908 RHOBTB2 0.44 6.09 0.32 3.06e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2274273 0.638 rs11622636 chr14:55647840 C/T cg04306507 chr14:55594613 LGALS3 0.49 9.79 0.47 4.65e-20 Protein biomarker; LUSC cis rs12410462 0.579 rs78343168 chr1:227621090 G/A cg10327440 chr1:227177885 CDC42BPA -0.66 -5.72 -0.3 2.34e-8 Major depressive disorder; LUSC cis rs6977940 0.730 rs11766514 chr7:2896271 C/T cg19731401 chr7:2775893 GNA12 0.63 7.3 0.37 2.17e-12 White matter integrity; LUSC cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.18 -0.41 6.1e-15 Axial length; LUSC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg15704280 chr7:45808275 SEPT13 -1.11 -24.44 -0.8 2.38e-76 Height; LUSC cis rs9378688 0.654 rs2505662 chr6:2326185 T/C cg12303981 chr6:2244766 GMDS -0.44 -6.12 -0.32 2.61e-9 Caudate nucleus volume; LUSC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.65 0.47 1.34e-19 Height; LUSC cis rs12188164 0.543 rs890972 chr5:462465 C/A cg16584290 chr5:462447 EXOC3 0.46 8.15 0.41 7.32e-15 Cystic fibrosis severity; LUSC cis rs72772090 0.539 rs72775817 chr5:96190709 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.88 -0.35 2.88e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg25019033 chr10:957182 NA -0.51 -6.32 -0.33 8.28e-10 Eosinophil percentage of granulocytes; LUSC cis rs8078723 1.000 rs56922390 chr17:38157021 C/G cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.82 -0.35 4.38e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg13206674 chr6:150067644 NUP43 0.56 8.7 0.43 1.51e-16 Lung cancer; LUSC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.62 -9.79 -0.47 4.52e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg25072359 chr17:41440525 NA 0.65 9.26 0.45 2.46e-18 Menopause (age at onset); LUSC cis rs1808579 0.935 rs4800493 chr18:21143932 T/C cg14672496 chr18:21087552 C18orf8 0.34 5.69 0.3 2.83e-8 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs7173743 0.756 rs8032771 chr15:79126059 A/G cg00540400 chr15:79124168 NA 0.36 6.18 0.32 1.84e-9 Coronary artery disease; LUSC cis rs1371867 0.846 rs1788205 chr8:101306546 G/C cg06002616 chr8:101225028 SPAG1 -0.46 -7.57 -0.38 3.77e-13 Atrioventricular conduction; LUSC cis rs9818758 0.545 rs11717978 chr3:48969036 T/A cg00383909 chr3:49044727 WDR6 1.3 11.92 0.55 1.51e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs9372253 1.000 rs9386894 chr6:110718853 A/G cg00083206 chr6:110721305 DDO -0.46 -8.29 -0.41 2.81e-15 Platelet distribution width; LUSC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg06618935 chr21:46677482 NA -0.38 -7.58 -0.38 3.51e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.56 -9.87 -0.48 2.51e-20 Bipolar disorder; LUSC cis rs807669 0.903 rs1780637 chr22:19178250 A/G cg02655711 chr22:19163373 SLC25A1 0.91 17.84 0.7 1.74e-50 Metabolite levels; LUSC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg03948781 chr1:205179583 DSTYK 0.3 5.66 0.3 3.31e-8 Mean corpuscular volume;Mean platelet volume; LUSC trans rs7589561 0.602 rs10196773 chr2:106397496 G/A cg26805882 chr4:174453287 NBLA00301 0.48 6.3 0.33 9.61e-10 Addiction; LUSC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -9.91 -0.48 1.83e-20 Developmental language disorder (linguistic errors); LUSC cis rs7937682 0.663 rs7116280 chr11:111659111 T/C cg09085632 chr11:111637200 PPP2R1B 0.94 12.83 0.57 6.37e-31 Primary sclerosing cholangitis; LUSC cis rs6570726 0.526 rs9403699 chr6:145730685 G/T cg23711669 chr6:146136114 FBXO30 0.4 5.79 0.3 1.66e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs6582630 0.577 rs12312748 chr12:38343326 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.62 -0.38 2.62e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg25767906 chr1:53392781 SCP2 -0.5 -9.21 -0.45 3.68e-18 Monocyte count; LUSC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.4e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg04013093 chr6:42928303 GNMT -0.27 -5.66 -0.3 3.34e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg22676075 chr6:135203613 NA 0.58 9.32 0.45 1.61e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs6601327 0.641 rs12542457 chr8:9564600 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -6.35 -0.33 6.9e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 8.16e-15 Axial length; LUSC cis rs12681287 0.640 rs6992944 chr8:87419308 G/T cg27223183 chr8:87520930 FAM82B 0.55 7.52 0.38 4.95e-13 Caudate activity during reward; LUSC cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg13609457 chr4:120235615 NA 0.41 5.64 0.3 3.55e-8 Corneal astigmatism; LUSC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg17264618 chr3:40429014 ENTPD3 0.34 7.22 0.37 3.53e-12 Renal cell carcinoma; LUSC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs175714 0.845 rs175702 chr14:75971133 G/T cg01624173 chr14:75981868 NA -0.44 -9.3 -0.45 1.87e-18 Lymphocyte counts; LUSC cis rs11758351 0.866 rs56186759 chr6:26207181 C/T cg23601095 chr6:26197514 HIST1H3D 0.68 7.51 0.38 5.59e-13 Gout;Renal underexcretion gout; LUSC cis rs8060686 0.641 rs2107369 chr16:68116018 A/C cg05110241 chr16:68378359 PRMT7 -0.5 -6.01 -0.31 4.89e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs10506458 1.000 rs73128779 chr12:63441852 T/G cg22491629 chr6:157744540 C6orf35 -0.9 -10.67 -0.5 4.68e-23 Hemostatic factors and hematological phenotypes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06609250 chr11:85522094 SYTL2 -0.42 -6.17 -0.32 1.98e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13217239 0.646 rs4269366 chr6:27016413 C/T cg09904177 chr6:26538194 HMGN4 0.5 7.85 0.39 5.78e-14 Schizophrenia; LUSC cis rs9840812 0.645 rs9883916 chr3:136208788 C/T cg15507776 chr3:136538369 TMEM22 0.43 5.74 0.3 2.11e-8 Fibrinogen levels; LUSC cis rs654351 0.543 rs622388 chr6:10387117 T/G cg04978078 chr6:10383147 NA -0.31 -5.82 -0.3 1.39e-8 Squamous cell lung carcinoma; LUSC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg20203395 chr5:56204925 C5orf35 -0.79 -10.33 -0.49 6.78e-22 Initial pursuit acceleration; LUSC cis rs10761482 0.861 rs10821737 chr10:62107802 A/G cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg08975724 chr8:8085496 FLJ10661 0.52 7.75 0.39 1.11e-13 Mood instability; LUSC trans rs1005277 0.579 rs1780121 chr10:38529437 C/A cg17830980 chr10:43048298 ZNF37B -0.57 -9.2 -0.45 3.96e-18 Extrinsic epigenetic age acceleration; LUSC cis rs4664308 1.000 rs4664308 chr2:160917497 A/G cg03641300 chr2:160917029 PLA2R1 -0.68 -11.31 -0.53 2.55e-25 Idiopathic membranous nephropathy; LUSC cis rs6574644 1.000 rs6574643 chr14:81774402 A/T cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.58 0.34 1.84e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs4919087 1.000 rs12221430 chr10:99061386 C/G cg25902810 chr10:99078978 FRAT1 0.5 7.24 0.37 3.05e-12 Monocyte count; LUSC cis rs7408868 0.908 rs62113794 chr19:15277337 C/A cg14696996 chr19:15285081 NOTCH3 0.96 8.62 0.43 2.65e-16 Pulse pressure; LUSC cis rs1580019 0.520 rs13228793 chr7:32711465 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.13 0.32 2.44e-9 Cognitive ability; LUSC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg20503657 chr10:835505 NA 1.19 16.28 0.67 2.87e-44 Eosinophil percentage of granulocytes; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg06873352 chr17:61820015 STRADA 0.71 12.3 0.56 6.28e-29 Prudent dietary pattern; LUSC cis rs79349575 0.756 rs2291726 chr17:47039254 T/C cg22482690 chr17:47019901 SNF8 -0.37 -6.88 -0.35 2.89e-11 Type 2 diabetes; LUSC cis rs9443189 0.530 rs614065 chr6:76315633 G/A cg01950844 chr6:76311363 SENP6 0.69 6.92 0.35 2.32e-11 Prostate cancer; LUSC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg07424592 chr7:64974309 NA 0.66 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs7100689 0.784 rs10736341 chr10:82061206 C/G cg00277334 chr10:82204260 NA -0.53 -7.33 -0.37 1.73e-12 Post bronchodilator FEV1; LUSC cis rs460214 0.528 rs4817954 chr21:40023857 C/T cg21578987 chr21:40029669 ERG 0.43 6.62 0.34 1.4e-10 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs9287719 0.967 rs2884233 chr2:10745303 G/A cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs2637266 0.597 rs2583065 chr10:78555915 A/G cg18941641 chr10:78392320 NA 0.38 7.03 0.36 1.19e-11 Pulmonary function; LUSC cis rs11039100 0.681 rs11039170 chr11:5845187 T/G cg05234568 chr11:5960015 NA -0.52 -5.85 -0.31 1.14e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.34 -0.42 2.01e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9828933 0.938 rs2578011 chr3:64004819 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.56 -6.1 -0.32 2.91e-9 Type 2 diabetes; LUSC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg06453172 chr10:134556979 INPP5A 0.49 6.46 0.33 3.63e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs1728785 1.000 rs4783657 chr16:68586322 G/T cg02972257 chr16:68554789 NA -0.5 -6.4 -0.33 5.31e-10 Ulcerative colitis; LUSC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg14784868 chr12:69753453 YEATS4 0.61 8.9 0.44 3.54e-17 Response to diuretic therapy; LUSC cis rs2580764 0.503 rs2972097 chr2:55267545 T/C cg20993754 chr2:55226987 RTN4 -0.39 -6.5 -0.34 2.86e-10 Mean platelet volume; LUSC trans rs60843830 1.000 rs17713729 chr2:249092 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 10.03 0.48 7.23e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4588572 0.643 rs1864173 chr5:77691158 C/T cg11547950 chr5:77652471 NA 0.53 7.46 0.38 7.57e-13 Triglycerides; LUSC cis rs7927592 0.913 rs948316 chr11:68309670 G/T cg20283391 chr11:68216788 NA -0.61 -8.48 -0.42 7.63e-16 Total body bone mineral density; LUSC cis rs6138458 1.000 rs227615 chr20:24908721 T/C cg06937882 chr20:24974362 C20orf3 -0.42 -7.0 -0.36 1.43e-11 Blood protein levels; LUSC trans rs3733585 0.699 rs7683283 chr4:9969974 T/C cg26043149 chr18:55253948 FECH -0.46 -7.04 -0.36 1.07e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs35000415 0.938 rs12531054 chr7:128644251 A/C cg19972273 chr7:128594194 NA -0.6 -6.59 -0.34 1.67e-10 Systemic lupus erythematosus; LUSC cis rs7681440 0.606 rs356184 chr4:90703233 A/G cg06632027 chr4:90757378 SNCA 0.36 5.65 0.3 3.4e-8 Dementia with Lewy bodies; LUSC cis rs262150 0.546 rs7798337 chr7:158801089 G/A cg19418458 chr7:158789849 NA 0.5 7.75 0.39 1.09e-13 Facial morphology (factor 20); LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg27588902 chr6:42928151 GNMT -0.3 -6.62 -0.34 1.45e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3816788 0.792 rs729180 chr8:21817245 C/T cg17168535 chr8:21777572 XPO7 0.85 15.54 0.65 2.22e-41 Lung cancer in ever smokers; LUSC cis rs7597155 0.935 rs10181122 chr2:69980910 C/T cg02498382 chr2:70120550 SNRNP27 -0.25 -5.87 -0.31 1.04e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1595825 0.891 rs73054817 chr2:198623751 A/G cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 5.92e-9 Ulcerative colitis; LUSC cis rs67460515 0.926 rs66508859 chr3:160946351 C/T cg03342759 chr3:160939853 NMD3 -0.53 -7.61 -0.38 2.78e-13 Parkinson's disease; LUSC cis rs1215050 0.765 rs644839 chr4:98716357 C/A cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.32e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2361710 0.611 rs12051781 chr17:78074468 A/G cg24585782 chr17:78113791 EIF4A3 -0.46 -7.21 -0.37 3.76e-12 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.72 0.63 3.61e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7267979 0.844 rs2257649 chr20:25263457 T/G cg14121845 chr20:25566513 NINL 0.3 5.66 0.3 3.29e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.5 -8.26 -0.41 3.46e-15 Lymphocyte counts; LUSC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg12292205 chr6:26970375 C6orf41 0.51 8.57 0.42 3.88e-16 Schizophrenia; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg25703541 chr22:24373054 LOC391322 -0.86 -14.04 -0.61 1.69e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01488865 chr20:61569319 C20orf11;DIDO1 -0.4 -6.0 -0.31 5.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg20887711 chr4:1340912 KIAA1530 0.42 5.8 0.3 1.56e-8 Obesity-related traits; LUSC cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.99 0.55 8.55e-28 Chronic sinus infection; LUSC cis rs4704187 0.687 rs6860441 chr5:74389799 G/A cg03227963 chr5:74354835 NA 0.32 6.82 0.35 4.21e-11 Response to amphetamines; LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg24846343 chr22:24311635 DDTL -0.59 -9.09 -0.45 9.09e-18 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs4805272 0.512 rs765484 chr19:29344663 A/G cg12667521 chr19:29218732 NA 0.53 6.14 0.32 2.32e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs11958404 0.932 rs6894528 chr5:157434788 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.29e-12 Platelet count; LUSC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg22535103 chr8:58192502 C8orf71 -0.71 -7.68 -0.39 1.81e-13 Developmental language disorder (linguistic errors); LUSC cis rs8056893 0.885 rs6499165 chr16:68326200 A/C cg02226672 chr16:68398533 SMPD3 0.34 5.96 0.31 6.31e-9 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs8044995 0.517 rs61593058 chr16:68384496 T/C cg05110241 chr16:68378359 PRMT7 -0.64 -8.15 -0.41 7.64e-15 Schizophrenia; LUSC cis rs10883723 1.000 rs10883723 chr10:104225832 T/C cg05855489 chr10:104503620 C10orf26 -0.71 -10.15 -0.49 2.92e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg18230493 chr5:56204884 C5orf35 -0.92 -13.95 -0.61 3.52e-35 Initial pursuit acceleration; LUSC cis rs13385 0.769 rs270166 chr5:139533279 A/C cg26211634 chr5:139558579 C5orf32 -0.4 -5.94 -0.31 7.24e-9 Atrial fibrillation; LUSC cis rs2637266 1.000 rs2130798 chr10:78329563 C/T cg18941641 chr10:78392320 NA 0.38 6.83 0.35 4.09e-11 Pulmonary function; LUSC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg03396347 chr1:1875803 NA 0.48 10.24 0.49 1.43e-21 Body mass index; LUSC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.66e-10 Lung cancer; LUSC cis rs73195822 0.667 rs60184376 chr12:111229975 T/C cg12870014 chr12:110450643 ANKRD13A 0.69 6.75 0.35 6.65e-11 Itch intensity from mosquito bite; LUSC trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg27661571 chr11:113659931 NA -0.7 -7.96 -0.4 2.78e-14 Hip circumference adjusted for BMI; LUSC cis rs4363385 0.647 rs56412380 chr1:153000705 T/C cg25856811 chr1:152973957 SPRR3 -0.4 -6.52 -0.34 2.64e-10 Inflammatory skin disease; LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.65 10.93 0.51 5.7e-24 Lymphocyte counts; LUSC cis rs142518269 1 rs142518269 chr2:24087095 G/A cg08917208 chr2:24149416 ATAD2B 0.98 10.26 0.49 1.15e-21 Mean corpuscular hemoglobin; LUSC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12667521 chr19:29218732 NA 0.56 8.64 0.43 2.35e-16 Methadone dose in opioid dependence; LUSC cis rs478304 0.654 rs10896034 chr11:65460783 T/A cg05805236 chr11:65401703 PCNXL3 -0.64 -10.61 -0.5 7.33e-23 Acne (severe); LUSC cis rs2404602 0.647 rs36114653 chr15:77025393 G/A cg23625390 chr15:77176239 SCAPER -0.67 -10.01 -0.48 8.51e-21 Blood metabolite levels; LUSC cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg18681998 chr4:17616180 MED28 0.81 14.59 0.62 1.22e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2692947 0.727 rs749459 chr2:96795714 G/A cg23100626 chr2:96804247 ASTL 0.28 7.01 0.36 1.34e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9399401 0.633 rs262118 chr6:142843054 C/A cg03128060 chr6:142623767 GPR126 0.51 7.89 0.4 4.44e-14 Chronic obstructive pulmonary disease; LUSC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg18230493 chr5:56204884 C5orf35 -0.88 -13.39 -0.59 4.99e-33 Initial pursuit acceleration; LUSC trans rs2243480 1.000 rs1723267 chr7:65473314 G/A cg10756647 chr7:56101905 PSPH 0.85 8.31 0.41 2.5e-15 Diabetic kidney disease; LUSC cis rs950881 0.867 rs10197862 chr2:102966549 A/G cg20060108 chr2:102954350 IL1RL1 0.47 6.18 0.32 1.91e-9 Allergy; LUSC cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.55 -0.42 4.55e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs603446 0.967 rs180370 chr11:116592365 C/T cg08653369 chr3:150644434 CLRN1 -0.3 -6.0 -0.31 5e-9 Triglycerides; LUSC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg07148914 chr20:33460835 GGT7 -0.55 -8.51 -0.42 5.81e-16 Height; LUSC trans rs7615952 0.546 rs2979306 chr3:125312130 C/A cg07211511 chr3:129823064 LOC729375 -0.51 -5.96 -0.31 6.32e-9 Blood pressure (smoking interaction); LUSC cis rs61935443 0.666 rs11107780 chr12:95299142 G/A cg21533806 chr12:95267307 NA 0.49 5.7 0.3 2.63e-8 Schizophrenia; LUSC cis rs7712401 0.791 rs10059964 chr5:122118293 A/G cg19077854 chr5:122220652 SNX24 0.35 7.83 0.39 6.55e-14 Mean platelet volume; LUSC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg04369109 chr6:150039330 LATS1 -0.5 -7.24 -0.37 3.18e-12 Lung cancer; LUSC trans rs8073060 0.586 rs8074800 chr17:33979148 A/G cg19694781 chr19:47549865 TMEM160 1.13 18.32 0.71 2.17e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs35146811 0.735 rs1727140 chr7:99815399 T/A cg22906224 chr7:99728672 NA -0.47 -6.6 -0.34 1.6e-10 Coronary artery disease; LUSC cis rs1451375 1.000 rs10250513 chr7:50621488 T/G cg18232548 chr7:50535776 DDC 0.51 7.83 0.39 6.32e-14 Malaria; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03352830 chr11:487213 PTDSS2 0.75 8.72 0.43 1.34e-16 Body mass index; LUSC cis rs73206853 0.764 rs7966591 chr12:110644045 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 7.97 0.4 2.56e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7927771 0.524 rs10838784 chr11:47882341 G/A cg20307385 chr11:47447363 PSMC3 0.48 6.99 0.36 1.46e-11 Subjective well-being; LUSC cis rs72781680 0.898 rs7589440 chr2:24038595 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs9303401 0.659 rs62081315 chr17:56781468 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs300703 0.542 rs300697 chr2:184496 C/T cg21211680 chr2:198530 NA -0.6 -7.34 -0.37 1.68e-12 Blood protein levels; LUSC cis rs6665290 0.935 rs6659424 chr1:227197875 A/G cg10327440 chr1:227177885 CDC42BPA -1.22 -40.13 -0.91 8.02e-130 Myeloid white cell count; LUSC cis rs2050392 0.517 rs302423 chr10:30772513 A/G cg18806716 chr10:30721971 MAP3K8 -0.59 -9.13 -0.45 6.66e-18 Inflammatory bowel disease; LUSC cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs9309473 1.000 rs7558944 chr2:73810909 T/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.55 -0.34 2.17e-10 Metabolite levels; LUSC cis rs2346177 0.844 rs4953371 chr2:46651143 T/A cg02822958 chr2:46747628 ATP6V1E2 0.37 6.51 0.34 2.69e-10 HDL cholesterol; LUSC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg11764359 chr7:65958608 NA 0.68 10.95 0.51 4.86e-24 Aortic root size; LUSC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg15790184 chr11:494944 RNH1 0.58 6.31 0.33 8.97e-10 Body mass index; LUSC cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg14584255 chr6:163149320 PACRG;PARK2 -0.34 -6.6 -0.34 1.66e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.69 -11.36 -0.53 1.64e-25 Systemic lupus erythematosus; LUSC cis rs9650657 0.812 rs11250072 chr8:10632121 C/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.42 -0.33 4.8e-10 Neuroticism; LUSC cis rs4148883 0.689 rs2602861 chr4:100030896 C/T cg12011299 chr4:100065546 ADH4 0.48 7.92 0.4 3.63e-14 Alcohol dependence; LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg22963979 chr7:1858916 MAD1L1 -0.68 -11.29 -0.53 2.9e-25 Bipolar disorder and schizophrenia; LUSC cis rs6700896 0.864 rs12030956 chr1:66115298 G/T cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs174601 0.861 rs174547 chr11:61570783 C/T cg19610905 chr11:61596333 FADS2 0.52 7.72 0.39 1.34e-13 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC trans rs61931739 0.500 rs7295779 chr12:34460652 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.37e-33 Morning vs. evening chronotype; LUSC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.67 0.34 1.05e-10 Lung cancer; LUSC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs459571 0.920 rs417142 chr9:136891370 G/T cg01294253 chr9:136912663 BRD3 0.36 6.24 0.32 1.31e-9 Platelet distribution width; LUSC cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.38 0.46 1.07e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3736594 0.759 rs6753736 chr2:27958855 C/G cg27432699 chr2:27873401 GPN1 -0.64 -9.0 -0.44 1.75e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.76 -0.3 1.93e-8 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18004316 chr2:208634121 FZD5 0.77 6.7 0.34 9.05e-11 Cognitive performance; LUSC cis rs7582180 0.630 rs13021801 chr2:100935129 C/A cg12002119 chr2:101014098 CHST10 0.34 5.71 0.3 2.48e-8 Intelligence (multi-trait analysis); LUSC cis rs3849570 1.000 rs3860595 chr3:81811784 A/G cg07356753 chr3:81810745 GBE1 -0.59 -9.38 -0.46 1.06e-18 Waist circumference;Body mass index; LUSC cis rs11048434 0.736 rs7957321 chr12:9120154 C/T cg23795048 chr12:9217529 LOC144571 0.34 5.87 0.31 1.04e-8 Sjögren's syndrome; LUSC trans rs11992162 0.613 rs6601634 chr8:11806456 T/C cg15556689 chr8:8085844 FLJ10661 -0.53 -7.61 -0.38 2.86e-13 Monocyte count; LUSC cis rs2204008 0.715 rs3899385 chr12:38169880 C/G cg26384229 chr12:38710491 ALG10B 0.9 15.55 0.65 2.12e-41 Bladder cancer; LUSC cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg19628046 chr18:33552617 C18orf21 -0.53 -6.62 -0.34 1.39e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg02487422 chr3:49467188 NICN1 0.48 7.63 0.39 2.46e-13 Resting heart rate; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg14092988 chr3:52407081 DNAH1 0.3 5.97 0.31 6.02e-9 Bipolar disorder; LUSC cis rs977987 0.806 rs11640473 chr16:75403289 C/A cg03315344 chr16:75512273 CHST6 0.48 9.25 0.45 2.73e-18 Dupuytren's disease; LUSC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg09359103 chr1:154839909 KCNN3 -0.69 -15.95 -0.66 5.7e-43 Prostate cancer; LUSC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg09365446 chr1:150670422 GOLPH3L 0.48 7.02 0.36 1.21e-11 Melanoma; LUSC trans rs7647973 0.710 rs1532204 chr3:49609477 C/G cg21659725 chr3:3221576 CRBN -0.71 -7.82 -0.39 7.08e-14 Menarche (age at onset); LUSC cis rs7336332 0.569 rs57724994 chr13:28010389 T/C cg22138327 chr13:27999177 GTF3A 0.68 9.24 0.45 2.98e-18 Weight; LUSC cis rs1153858 1.000 rs1153849 chr15:45695695 G/A cg14582100 chr15:45693742 SPATA5L1 0.56 10.05 0.48 6.03e-21 Homoarginine levels; LUSC trans rs11723530 0.538 rs13142537 chr4:170812339 C/T cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.17 -0.32 2.01e-9 Myopia (pathological); LUSC cis rs7599312 0.586 rs7565257 chr2:213388276 G/A cg16329650 chr2:213403929 ERBB4 0.51 7.38 0.37 1.31e-12 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg13175981 chr1:150552382 MCL1 -0.41 -5.67 -0.3 3.17e-8 Tonsillectomy; LUSC cis rs34734847 1.000 rs3752531 chr12:121157851 A/G cg21892295 chr12:121157589 UNC119B -0.52 -9.54 -0.46 3.07e-19 Mean corpuscular volume; LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.68 0.6 3.93e-34 Platelet count; LUSC cis rs9560113 0.959 rs9555802 chr13:112179504 T/C cg14154082 chr13:112174009 NA 0.37 7.68 0.39 1.8e-13 Menarche (age at onset); LUSC cis rs6981523 0.553 rs2409730 chr8:11060638 C/A cg21775007 chr8:11205619 TDH -0.49 -6.64 -0.34 1.3e-10 Neuroticism; LUSC cis rs72781680 0.898 rs72780123 chr2:23996009 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs12579753 0.917 rs12316644 chr12:82205497 C/T cg07988820 chr12:82153109 PPFIA2 0.42 6.18 0.32 1.9e-9 Resting heart rate; LUSC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg00745463 chr17:30367425 LRRC37B -0.65 -8.07 -0.4 1.31e-14 Hip circumference adjusted for BMI; LUSC cis rs11758351 1.000 rs111596617 chr6:26191678 A/T cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs73200209 0.665 rs17498599 chr12:116597253 C/T cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg04518342 chr5:131593106 PDLIM4 0.34 6.17 0.32 1.97e-9 Blood metabolite levels; LUSC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg19748678 chr4:122722346 EXOSC9 0.73 10.83 0.51 1.3e-23 Type 2 diabetes; LUSC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg10253484 chr15:75165896 SCAMP2 -0.48 -7.23 -0.37 3.41e-12 Breast cancer; LUSC cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC trans rs1814175 0.935 rs7950947 chr11:49668369 C/T cg03929089 chr4:120376271 NA -1.0 -18.3 -0.71 2.56e-52 Height; LUSC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.21 0.32 1.62e-9 Schizophrenia; LUSC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg16624210 chr5:671434 TPPP 0.5 6.34 0.33 7.27e-10 Obesity-related traits; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg13397359 chr6:42928475 GNMT 0.62 10.29 0.49 9.19e-22 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs7824557 0.564 rs2736288 chr8:11228100 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -8.41 -0.42 1.24e-15 Retinal vascular caliber; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg20531166 chr11:82782814 RAB30 0.41 6.55 0.34 2.24e-10 Schizophrenia; LUSC cis rs7264396 0.790 rs6058297 chr20:34271861 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.65 -0.47 1.37e-19 Total cholesterol levels; LUSC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg13939156 chr17:80058883 NA 0.34 6.7 0.34 8.7e-11 Life satisfaction; LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg09655341 chr17:79618100 PDE6G 0.27 6.31 0.33 9.05e-10 Eye color traits; LUSC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg11247378 chr22:39784982 NA -0.66 -13.17 -0.58 3.35e-32 Intelligence (multi-trait analysis); LUSC cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg24692254 chr21:30365293 RNF160 -0.78 -13.91 -0.61 5.29e-35 Dental caries; LUSC cis rs2404602 0.692 rs57178708 chr15:76904069 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.02 0.36 1.22e-11 Blood metabolite levels; LUSC cis rs9318086 0.712 rs9510917 chr13:24442846 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.39 5.68 0.3 2.96e-8 Myopia (pathological); LUSC trans rs4942242 0.663 rs17460812 chr13:44215504 A/G cg19169023 chr15:41853346 TYRO3 -0.57 -9.12 -0.45 7.42e-18 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg00339695 chr16:24857497 SLC5A11 0.39 6.72 0.34 8.02e-11 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg00166722 chr3:10149974 C3orf24 0.6 7.97 0.4 2.62e-14 Alzheimer's disease; LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg02018176 chr4:1364513 KIAA1530 0.53 9.2 0.45 3.96e-18 Obesity-related traits; LUSC cis rs6714016 0.744 rs2551347 chr2:23912401 C/T cg08917208 chr2:24149416 ATAD2B -0.56 -7.58 -0.38 3.41e-13 Plateletcrit; LUSC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg06618935 chr21:46677482 NA -0.37 -7.4 -0.38 1.09e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg15423357 chr2:25149977 NA 0.45 9.12 0.45 7.03e-18 Body mass index; LUSC cis rs9443645 0.527 rs7756996 chr6:79509367 A/C cg05283184 chr6:79620031 NA -0.44 -8.16 -0.41 6.98e-15 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.630 rs10282584 chr7:1081442 C/T cg06145435 chr7:1022769 CYP2W1 0.28 6.11 0.32 2.74e-9 Longevity;Endometriosis; LUSC cis rs11229555 0.645 rs11601296 chr11:58423297 A/G cg15696309 chr11:58395628 NA -0.66 -7.01 -0.36 1.37e-11 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg27094323 chr7:1216898 NA -0.45 -7.88 -0.4 4.66e-14 Longevity;Endometriosis; LUSC cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg02527881 chr3:46936655 PTH1R 0.38 6.63 0.34 1.32e-10 Colorectal cancer; LUSC cis rs9303280 0.901 rs12936231 chr17:38029120 C/G cg10909506 chr17:38081995 ORMDL3 0.32 5.75 0.3 2e-8 Self-reported allergy; LUSC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg14343924 chr8:8086146 FLJ10661 0.45 6.39 0.33 5.48e-10 Myopia (pathological); LUSC cis rs11039100 0.607 rs34792182 chr11:5782874 G/C cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs35110281 0.806 rs1454649 chr21:45032982 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.82 0.54 3.63e-27 Mean corpuscular volume; LUSC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.79 0.3 1.61e-8 Menopause (age at onset); LUSC cis rs11148252 0.774 rs9536066 chr13:52983981 A/G cg00495681 chr13:53174319 NA 0.6 10.52 0.5 1.54e-22 Lewy body disease; LUSC trans rs9860340 0.730 rs60936504 chr3:87640246 T/C cg03644585 chr7:884825 UNC84A 0.42 5.99 0.31 5.4e-9 Electroencephalographic traits in alcoholism; LUSC cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg06784218 chr1:46089804 CCDC17 -0.47 -8.79 -0.43 7.83e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6782228 0.606 rs2253144 chr3:128329920 C/T cg16766828 chr3:128327626 NA 0.31 5.79 0.3 1.63e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs7584330 0.737 rs61212490 chr2:238365230 T/C cg16989719 chr2:238392110 NA -0.41 -7.25 -0.37 3e-12 Prostate cancer; LUSC cis rs5758659 0.904 rs134877 chr22:42662371 C/T cg15557168 chr22:42548783 NA -0.43 -7.24 -0.37 3.07e-12 Cognitive function; LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg01802117 chr1:53393560 SCP2 -0.36 -5.86 -0.31 1.1e-8 Monocyte count; LUSC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.31 0.45 1.82e-18 Monocyte percentage of white cells; LUSC cis rs6121246 0.909 rs57726761 chr20:30314046 A/G cg18721089 chr20:30220636 NA -0.34 -5.89 -0.31 9.62e-9 Mean corpuscular hemoglobin; LUSC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg02018176 chr4:1364513 KIAA1530 0.53 9.24 0.45 2.99e-18 Obesity-related traits; LUSC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg08470875 chr2:26401718 FAM59B -0.71 -9.38 -0.46 1.05e-18 Gut microbiome composition (summer); LUSC cis rs1670533 1.000 rs7669399 chr4:1058478 T/G cg02018176 chr4:1364513 KIAA1530 0.44 6.06 0.31 3.59e-9 Recombination rate (females); LUSC cis rs7843479 0.601 rs2306646 chr8:21846586 C/G cg17168535 chr8:21777572 XPO7 0.85 15.57 0.65 1.75e-41 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg03030879 chr14:75389066 RPS6KL1 -0.41 -7.85 -0.39 5.63e-14 Caffeine consumption; LUSC cis rs6542838 0.554 rs4311103 chr2:99538362 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.51 -0.38 5.43e-13 Fear of minor pain; LUSC cis rs9788682 1.000 rs7181245 chr15:78814389 C/T cg18825076 chr15:78729989 IREB2 0.47 6.4 0.33 5.32e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs8078723 0.510 rs3859189 chr17:38137033 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.57 9.86 0.47 2.63e-20 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs231513 0.954 rs231506 chr17:41970191 A/G cg26893861 chr17:41843967 DUSP3 -0.54 -6.58 -0.34 1.86e-10 Cognitive function; LUSC cis rs10203711 0.933 rs12692238 chr2:239553940 T/C cg14580085 chr2:239553406 NA 0.38 6.39 0.33 5.73e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg21951975 chr1:209979733 IRF6 0.58 7.24 0.37 3.05e-12 Cleft lip with or without cleft palate; LUSC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg06636001 chr8:8085503 FLJ10661 0.64 10.62 0.5 6.98e-23 Mood instability; LUSC cis rs12618769 0.597 rs3754888 chr2:99090674 T/C cg10123293 chr2:99228465 UNC50 0.45 7.54 0.38 4.41e-13 Bipolar disorder; LUSC cis rs554111 0.656 rs17450813 chr1:21264308 T/C cg01072550 chr1:21505969 NA 0.4 6.14 0.32 2.32e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg16647868 chr5:131706066 SLC22A5 0.4 6.29 0.33 1.01e-9 Breast cancer; LUSC cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg17420585 chr12:42539391 GXYLT1 -0.36 -7.02 -0.36 1.23e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.09e-30 Aortic root size; LUSC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg26039829 chr8:22132926 PIWIL2 0.42 7.66 0.39 2.01e-13 Hypertriglyceridemia; LUSC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg07936489 chr17:37558343 FBXL20 -0.63 -8.9 -0.44 3.55e-17 Glomerular filtration rate (creatinine); LUSC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg24154853 chr7:158122151 PTPRN2 0.43 8.3 0.41 2.57e-15 Calcium levels; LUSC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg13902645 chr11:5959945 NA 0.71 11.45 0.53 7.75e-26 DNA methylation (variation); LUSC cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg15839431 chr19:19639596 YJEFN3 -0.59 -6.54 -0.34 2.37e-10 Bipolar disorder; LUSC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg20821713 chr7:1055600 C7orf50 -0.55 -6.8 -0.35 4.9e-11 Bronchopulmonary dysplasia; LUSC cis rs11190604 1.000 rs10786598 chr10:102291579 G/A cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11971779 0.680 rs7788777 chr7:139055193 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs4727027 0.631 rs62507511 chr7:148796080 C/A cg23583168 chr7:148888333 NA -0.85 -14.74 -0.63 3.14e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg00101154 chr16:420108 MRPL28 -0.48 -8.38 -0.42 1.54e-15 Bone mineral density (spine);Bone mineral density; LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.06 0.36 9.53e-12 Bipolar disorder; LUSC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg18876405 chr7:65276391 NA 0.58 9.57 0.46 2.48e-19 Aortic root size; LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg06074448 chr4:187884817 NA -0.47 -7.81 -0.39 7.42e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs877282 1.000 rs12763443 chr10:771941 G/A cg17470449 chr10:769945 NA 0.56 7.62 0.38 2.72e-13 Uric acid levels; LUSC cis rs7666738 0.609 rs35214820 chr4:98864692 G/A cg17366294 chr4:99064904 C4orf37 0.55 8.44 0.42 1.01e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs2348418 0.864 rs6487689 chr12:28713034 C/T cg13890972 chr12:28721907 NA -0.34 -5.85 -0.3 1.18e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg06640241 chr16:89574553 SPG7 0.67 10.69 0.5 3.98e-23 Multiple myeloma (IgH translocation); LUSC trans rs6991952 0.845 rs7822766 chr8:25742279 A/T cg02047300 chr5:140208201 PCDHA6;PCDHA2;PCDHA1;PCDHA5;PCDHA3;PCDHA4 -0.43 -5.97 -0.31 6.08e-9 Inguinal hernia; LUSC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg25036284 chr2:26402008 FAM59B -0.68 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08755283 chr5:118324104 DTWD2 -0.5 -6.89 -0.35 2.74e-11 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs113835537 0.529 rs4542420 chr11:66277610 G/C cg24851651 chr11:66362959 CCS 0.54 8.03 0.4 1.64e-14 Airway imaging phenotypes; LUSC cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg11764359 chr7:65958608 NA -0.52 -6.83 -0.35 4e-11 Aortic root size; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg27094323 chr7:1216898 NA -0.36 -6.5 -0.33 3.01e-10 Longevity;Endometriosis; LUSC cis rs4285028 0.948 rs34181646 chr3:121705373 T/A cg11130432 chr3:121712080 ILDR1 -0.65 -10.05 -0.48 5.97e-21 Multiple sclerosis; LUSC cis rs6977660 1.000 rs57916046 chr7:19800542 T/C cg05791153 chr7:19748676 TWISTNB 0.63 6.79 0.35 5e-11 Thyroid stimulating hormone; LUSC cis rs10871290 0.881 rs4099290 chr16:74468889 A/G cg01733217 chr16:74700730 RFWD3 -0.62 -8.99 -0.44 1.92e-17 Breast cancer; LUSC cis rs3741151 0.892 rs7105681 chr11:73059341 G/A cg17517138 chr11:73019481 ARHGEF17 0.91 8.29 0.41 2.83e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs701145 0.585 rs1713811 chr3:153874566 G/A cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg09526685 chr4:187126073 CYP4V2 -0.64 -6.36 -0.33 6.59e-10 Blood protein levels; LUSC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg21132104 chr15:45694354 SPATA5L1 -0.58 -8.24 -0.41 3.84e-15 Homoarginine levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16586152 chr7:106301062 FLJ36031 -0.45 -6.92 -0.35 2.32e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4268898 0.722 rs7563958 chr2:24422381 C/A cg06627628 chr2:24431161 ITSN2 0.61 8.75 0.43 1.08e-16 Asthma; LUSC cis rs679087 0.932 rs7312697 chr12:29933069 T/C cg14258853 chr12:29935411 TMTC1 0.9 15.97 0.66 4.5e-43 Schizophrenia; LUSC cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs7760949 0.963 rs1467729 chr6:13911167 C/T cg27413430 chr6:13925136 RNF182 -0.48 -7.39 -0.37 1.18e-12 Mean corpuscular hemoglobin concentration; LUSC trans rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.74 -13.47 -0.59 2.5e-33 Brugada syndrome; LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg04166393 chr7:2884313 GNA12 -0.47 -6.34 -0.33 7.56e-10 Height; LUSC cis rs2404602 0.684 rs8029283 chr15:76837140 A/G cg23625390 chr15:77176239 SCAPER -0.63 -9.44 -0.46 6.78e-19 Blood metabolite levels; LUSC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.05 0.31 3.83e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg24675658 chr1:53192096 ZYG11B 0.59 9.22 0.45 3.51e-18 Monocyte count; LUSC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg04369109 chr6:150039330 LATS1 -0.58 -8.57 -0.42 4e-16 Lung cancer; LUSC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg22875332 chr1:76189707 ACADM 0.82 14.39 0.62 7.5e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs2219968 0.887 rs1947897 chr8:78946874 G/C cg00738934 chr8:78996279 NA 0.34 5.73 0.3 2.23e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7659604 0.502 rs11098640 chr4:122675875 G/A cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs4363385 0.747 rs6671414 chr1:152974119 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.88 -0.4 4.74e-14 Inflammatory skin disease; LUSC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg07274523 chr3:49395745 GPX1 0.67 10.27 0.49 1.11e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC trans rs11039798 1.000 rs12281162 chr11:48650491 T/C cg15704280 chr7:45808275 SEPT13 0.72 6.8 0.35 4.88e-11 Axial length; LUSC cis rs2070488 0.662 rs6599202 chr3:38480651 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 10.44 0.5 2.85e-22 Electrocardiographic conduction measures; LUSC cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg06552810 chr11:31128660 NA 0.42 7.24 0.37 3.07e-12 Red blood cell count; LUSC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs2243480 1.000 rs78803505 chr7:65382572 A/T cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs9788721 0.934 rs1317286 chr15:78896129 A/G cg18825076 chr15:78729989 IREB2 -0.53 -8.55 -0.42 4.42e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9467773 0.572 rs62394558 chr6:26604650 G/A cg11502198 chr6:26597334 ABT1 0.68 10.81 0.51 1.45e-23 Intelligence (multi-trait analysis); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg14016074 chr11:809449 RPLP2 0.73 6.03 0.31 4.3e-9 Body mass index; LUSC cis rs10779751 1.000 rs742824 chr1:11274022 G/A cg08854313 chr1:11322531 MTOR 0.92 16.39 0.67 1.02e-44 Body mass index; LUSC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg04369109 chr6:150039330 LATS1 -0.41 -6.0 -0.31 5.12e-9 Testicular germ cell tumor; LUSC cis rs4332037 0.539 rs11762636 chr7:2061111 C/A cg23422044 chr7:1970798 MAD1L1 -0.57 -6.29 -0.33 1.02e-9 Bipolar disorder; LUSC cis rs7674212 0.570 rs12501621 chr4:104095505 T/G cg16532752 chr4:104119610 CENPE -0.49 -7.2 -0.37 4.02e-12 Type 2 diabetes; LUSC trans rs9929218 0.954 rs34530130 chr16:68827620 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -10.81 -0.51 1.44e-23 Colorectal cancer; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg02951883 chr7:2050386 MAD1L1 -0.4 -7.01 -0.36 1.33e-11 Bipolar disorder and schizophrenia; LUSC cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg12573674 chr2:1569213 NA -0.63 -8.74 -0.43 1.15e-16 IgG glycosylation; LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg08736216 chr1:53307985 ZYG11A -0.27 -5.66 -0.3 3.26e-8 Monocyte count; LUSC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.99 -0.36 1.47e-11 Aortic root size; LUSC cis rs11992162 0.613 rs6601634 chr8:11806456 T/C cg21775007 chr8:11205619 TDH -0.43 -5.92 -0.31 8.18e-9 Monocyte count; LUSC cis rs12594515 1.000 rs12185095 chr15:45994635 G/T cg19682013 chr15:45996608 NA 0.39 5.79 0.3 1.58e-8 Waist circumference;Weight; LUSC trans rs7824557 0.707 rs3808518 chr8:11143272 A/C cg15556689 chr8:8085844 FLJ10661 -0.57 -8.96 -0.44 2.34e-17 Retinal vascular caliber; LUSC cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg14844989 chr11:31128820 NA -0.39 -6.17 -0.32 1.97e-9 Red blood cell count; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.47 6.92 0.35 2.31e-11 Prudent dietary pattern; LUSC cis rs11166629 0.637 rs6578230 chr8:135564113 A/G cg27224718 chr8:135614730 ZFAT 0.53 7.6 0.38 3.11e-13 Smoking quantity; LUSC trans rs1997103 0.822 rs10273426 chr7:55417857 G/A cg20935933 chr6:143382018 AIG1 0.48 6.48 0.33 3.36e-10 QRS interval (sulfonylurea treatment interaction); LUSC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg07716408 chr11:68623521 NA -0.33 -6.18 -0.32 1.85e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6669072 0.967 rs4101233 chr1:91238773 C/T cg08895590 chr1:91227319 NA -0.39 -8.75 -0.43 1.09e-16 Cognitive function; LUSC cis rs734999 0.545 rs6666788 chr1:2567500 A/G cg18932078 chr1:2524107 MMEL1 -0.31 -6.84 -0.35 3.9e-11 Ulcerative colitis; LUSC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs243505 0.762 rs933436 chr7:148487329 A/C cg09806900 chr7:148480153 CUL1 -0.55 -8.27 -0.41 3.23e-15 Inflammatory bowel disease;Crohn's disease; LUSC trans rs61931739 0.513 rs10844698 chr12:33890158 C/T cg26384229 chr12:38710491 ALG10B 0.55 8.59 0.43 3.34e-16 Morning vs. evening chronotype; LUSC cis rs9388451 0.903 rs9388446 chr6:126064920 T/A cg05901451 chr6:126070800 HEY2 -0.94 -18.53 -0.71 3.23e-53 Brugada syndrome; LUSC cis rs727505 0.721 rs56269941 chr7:124768732 T/A cg23710748 chr7:124431027 NA -0.39 -7.01 -0.36 1.29e-11 Lewy body disease; LUSC cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg05343316 chr1:45956843 TESK2 0.74 9.96 0.48 1.27e-20 Platelet count; LUSC cis rs2559856 1.000 rs2695299 chr12:102082664 G/A cg12924262 chr12:102091054 CHPT1 0.42 5.82 0.3 1.38e-8 Blood protein levels; LUSC cis rs6424115 0.931 rs2473377 chr1:24148260 T/C cg10978503 chr1:24200527 CNR2 0.5 11.46 0.53 7.02e-26 Immature fraction of reticulocytes; LUSC cis rs239198 0.534 rs1813223 chr6:101331909 C/T cg09795085 chr6:101329169 ASCC3 0.42 6.01 0.31 4.77e-9 Menarche (age at onset); LUSC cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg24558204 chr6:135376177 HBS1L 0.68 10.82 0.51 1.32e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05700333 chr5:131892723 RAD50 0.43 7.01 0.36 1.31e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg03146154 chr1:46216737 IPP -0.52 -7.71 -0.39 1.5e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2786098 0.656 rs34261593 chr1:197530702 T/C cg16005942 chr6:160526640 IGF2R 0.51 6.03 0.31 4.34e-9 Asthma; LUSC cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg17143192 chr8:8559678 CLDN23 0.63 9.03 0.44 1.37e-17 Obesity-related traits; LUSC cis rs3540 0.553 rs4031431 chr15:90990782 G/T cg10434728 chr15:90938212 IQGAP1 0.43 8.51 0.42 6.14e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg20608306 chr11:116969690 SIK3 -0.36 -6.0 -0.31 5.09e-9 Blood protein levels; LUSC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg06363034 chr20:62225388 GMEB2 -0.46 -7.72 -0.39 1.4e-13 Glioblastoma; LUSC cis rs870825 0.616 rs28666955 chr4:185631338 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.12 0.58 5.24e-32 Blood protein levels; LUSC cis rs727505 1.000 rs56387611 chr7:124479180 G/A cg23710748 chr7:124431027 NA -0.42 -7.47 -0.38 6.9e-13 Lewy body disease; LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg09365446 chr1:150670422 GOLPH3L 0.47 6.79 0.35 5.16e-11 Melanoma; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.96 0.4 2.64e-14 Prudent dietary pattern; LUSC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.48 -0.38 6.54e-13 Personality dimensions; LUSC cis rs7267979 0.868 rs6107019 chr20:25233985 C/T cg08601574 chr20:25228251 PYGB 0.47 7.3 0.37 2.14e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6693567 0.526 rs3818978 chr1:150266338 T/A cg15654264 chr1:150340011 RPRD2 -0.45 -7.23 -0.37 3.39e-12 Migraine; LUSC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg18827107 chr12:86230957 RASSF9 -0.44 -6.56 -0.34 2.07e-10 Major depressive disorder; LUSC cis rs6834538 0.577 rs10034556 chr4:113449650 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.35 5.71 0.3 2.5e-8 Free thyroxine concentration; LUSC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg25036284 chr2:26402008 FAM59B -0.71 -9.93 -0.48 1.55e-20 Gut microbiome composition (summer); LUSC cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.51 -7.14 -0.36 5.9e-12 Cognitive ability; LUSC cis rs6574644 0.959 rs8003051 chr14:81780409 G/A cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs6430585 0.527 rs76380759 chr2:136438517 G/A cg07169764 chr2:136633963 MCM6 1.04 13.89 0.6 6.38e-35 Corneal structure; LUSC cis rs2969070 0.674 rs886630 chr7:2528126 G/T cg03277898 chr7:2518824 NA -0.29 -6.17 -0.32 2e-9 Diastolic blood pressure; LUSC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg15649852 chr7:65879115 NA 0.41 5.78 0.3 1.67e-8 Aortic root size; LUSC cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg22875332 chr1:76189707 ACADM -0.39 -5.73 -0.3 2.2e-8 Daytime sleep phenotypes; LUSC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.52 -6.62 -0.34 1.46e-10 Schizophrenia; LUSC cis rs2692947 0.732 rs56847058 chr2:96406893 C/T cg23100626 chr2:96804247 ASTL 0.29 6.89 0.35 2.78e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs61931739 0.500 rs11053246 chr12:34516620 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.54 0.5 1.25e-22 Morning vs. evening chronotype; LUSC cis rs2637266 0.729 rs860166 chr10:78549111 C/T cg18941641 chr10:78392320 NA 0.37 6.66 0.34 1.12e-10 Pulmonary function; LUSC cis rs9303401 0.659 rs34556735 chr17:56694447 A/C cg25039879 chr17:56429692 SUPT4H1 0.69 9.17 0.45 4.94e-18 Cognitive test performance; LUSC cis rs9807841 0.592 rs3810155 chr19:10764867 C/G cg09936142 chr19:10668400 KRI1 -0.41 -6.68 -0.34 9.95e-11 Inflammatory skin disease; LUSC cis rs12368653 0.641 rs7311632 chr12:58086340 A/C cg18357645 chr12:58087776 OS9 0.42 6.31 0.33 9.11e-10 Multiple sclerosis; LUSC cis rs35123781 1.000 rs34510678 chr5:139064835 C/T cg10513866 chr5:139070639 NA 0.44 8.58 0.42 3.62e-16 Schizophrenia; LUSC cis rs4253772 0.575 rs9615364 chr22:46797503 G/A cg24881330 chr22:46731750 TRMU 0.72 5.72 0.3 2.43e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.95 0.36 1.9e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg22823121 chr1:150693482 HORMAD1 -0.57 -8.83 -0.44 6.01e-17 Tonsillectomy; LUSC trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg03929089 chr4:120376271 NA -0.75 -9.19 -0.45 4.36e-18 Coronary artery disease; LUSC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.06 -0.31 3.72e-9 Total body bone mineral density; LUSC cis rs11051970 0.918 rs11051969 chr12:32537123 T/C cg24626660 chr12:32551988 NA 0.38 6.18 0.32 1.84e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg07424592 chr7:64974309 NA 0.67 5.88 0.31 9.86e-9 Diabetic kidney disease; LUSC cis rs12530845 1.000 rs6979439 chr7:135329004 A/G cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs10761482 0.500 rs7906760 chr10:62286653 A/T cg18175470 chr10:62150864 ANK3 -0.48 -7.19 -0.37 4.25e-12 Schizophrenia; LUSC trans rs9747201 0.962 rs62079995 chr17:80076624 C/T cg07393940 chr7:158741817 NA -0.55 -8.51 -0.42 5.79e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6582630 0.538 rs12304844 chr12:38335870 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.14 -0.32 2.32e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg03579872 chr1:53393473 SCP2 -0.39 -5.74 -0.3 2.09e-8 Monocyte count; LUSC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg24112000 chr20:60950667 NA 0.37 6.88 0.35 3e-11 Colorectal cancer; LUSC cis rs8017423 0.967 rs55894943 chr14:90714799 A/G cg04374321 chr14:90722782 PSMC1 0.75 11.93 0.55 1.46e-27 Mortality in heart failure; LUSC cis rs11608355 0.545 rs2302707 chr12:109893797 G/A cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs9837602 1.000 rs9841186 chr3:99795651 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -6.36 -0.33 6.53e-10 Breast cancer; LUSC cis rs12701220 0.597 rs10253153 chr7:1001974 G/A cg26769984 chr7:1090371 C7orf50 0.44 6.27 0.32 1.13e-9 Bronchopulmonary dysplasia; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.68 10.34 0.49 6.33e-22 Lymphocyte counts; LUSC cis rs1971762 0.521 rs5009146 chr12:54089297 A/C cg23533419 chr12:54090519 NA -0.37 -6.06 -0.31 3.76e-9 Height; LUSC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs360798 0.512 rs2539978 chr2:63195179 T/C cg17519650 chr2:63277830 OTX1 0.51 7.04 0.36 1.08e-11 Coronary artery disease; LUSC cis rs2486288 0.656 rs8039352 chr15:45551790 A/G cg04036182 chr15:45458818 NA -0.37 -6.01 -0.31 4.88e-9 Glomerular filtration rate; LUSC cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg00677455 chr12:58241039 CTDSP2 0.7 10.55 0.5 1.21e-22 Intelligence (multi-trait analysis); LUSC cis rs9309473 0.948 rs7603647 chr2:73817238 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.56 -0.34 2.1e-10 Metabolite levels; LUSC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg06636001 chr8:8085503 FLJ10661 0.58 8.39 0.42 1.37e-15 Neuroticism; LUSC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg18252515 chr7:66147081 NA -1.23 -13.96 -0.61 3.2e-35 Diabetic kidney disease; LUSC cis rs1160297 0.609 rs10164868 chr2:53095923 G/T cg07782112 chr2:53107842 NA 0.43 6.99 0.36 1.51e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg01802117 chr1:53393560 SCP2 -0.35 -5.73 -0.3 2.22e-8 Monocyte count; LUSC cis rs9814567 1.000 rs11927068 chr3:134266321 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs1493916 0.748 rs1845386 chr18:31318256 C/G cg27147174 chr7:100797783 AP1S1 -0.54 -8.44 -0.42 9.85e-16 Life satisfaction; LUSC cis rs2294693 0.898 rs6458195 chr6:40972498 A/T cg14769373 chr6:40998127 UNC5CL 0.42 6.25 0.32 1.26e-9 Gastric cancer;Non-cardia gastric cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01578996 chr19:57752011 ZNF805 -0.4 -5.99 -0.31 5.46e-9 Electrocardiographic conduction measures; LUSC cis rs738322 0.967 rs4385 chr22:38573229 T/C cg25457927 chr22:38595422 NA -0.41 -8.73 -0.43 1.24e-16 Cutaneous nevi; LUSC cis rs12478296 0.901 rs73007142 chr2:243010852 T/C cg06360820 chr2:242988706 NA -1.1 -11.29 -0.53 2.89e-25 Obesity-related traits; LUSC cis rs7180079 1.000 rs3784381 chr15:64449839 G/T cg08069370 chr15:64387884 SNX1 -0.55 -5.94 -0.31 7.33e-9 Monocyte count; LUSC trans rs7980799 0.711 rs12319055 chr12:33626509 C/T cg26384229 chr12:38710491 ALG10B -0.58 -8.69 -0.43 1.69e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg03060546 chr3:49711283 APEH 0.71 11.85 0.54 2.69e-27 Resting heart rate; LUSC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -8.61 -0.43 2.86e-16 Bipolar disorder and schizophrenia; LUSC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg05738196 chr6:26577821 NA 0.47 6.8 0.35 4.7e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.02 0.31 4.49e-9 Menopause (age at onset); LUSC cis rs752010 0.695 rs11210509 chr1:42109311 A/G cg06885757 chr1:42089581 HIVEP3 0.44 8.31 0.41 2.37e-15 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg15556689 chr8:8085844 FLJ10661 -0.66 -9.9 -0.48 2.04e-20 Mood instability; LUSC cis rs7586879 0.964 rs13412941 chr2:25102709 C/T cg01884057 chr2:25150051 NA 0.41 8.53 0.42 5.31e-16 Body mass index; LUSC cis rs12594515 1.000 rs6493170 chr15:45987019 G/A cg19682013 chr15:45996608 NA 0.4 6.05 0.31 3.83e-9 Waist circumference;Weight; LUSC cis rs1419980 0.673 rs1978284 chr12:7771151 G/A cg25828445 chr12:7781288 NA 0.61 6.46 0.33 3.65e-10 HDL cholesterol levels; LUSC cis rs427394 0.664 rs274701 chr5:6728707 C/A cg10857441 chr5:6722123 POLS -0.44 -8.67 -0.43 1.88e-16 Menopause (age at onset); LUSC cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg05868516 chr6:26286170 HIST1H4H 0.37 6.09 0.32 3.03e-9 Educational attainment; LUSC cis rs1800469 1.000 rs1549933 chr19:41871142 A/G cg09537434 chr19:41945824 ATP5SL -0.59 -7.82 -0.39 7.13e-14 Colorectal cancer; LUSC cis rs3126085 0.935 rs4845733 chr1:152162568 T/C cg26876637 chr1:152193138 HRNR 0.45 6.19 0.32 1.81e-9 Atopic dermatitis; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg13560548 chr3:10150139 C3orf24 0.54 7.85 0.39 5.9e-14 Alzheimer's disease; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg02951883 chr7:2050386 MAD1L1 -0.35 -5.95 -0.31 6.83e-9 Bipolar disorder and schizophrenia; LUSC trans rs5760842 0.538 rs1076047 chr22:25495049 T/C cg16733866 chr21:42792609 MX1 0.51 7.08 0.36 8.65e-12 Recurrent major depressive disorder; LUSC cis rs12421382 0.636 rs60266280 chr11:109387766 A/C cg27471124 chr11:109292789 C11orf87 0.43 7.76 0.39 1.02e-13 Schizophrenia; LUSC trans rs61931739 0.500 rs7309421 chr12:34553795 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.4 0.64 7.91e-41 Morning vs. evening chronotype; LUSC trans rs4911259 0.552 rs6057663 chr20:31463071 G/T cg09781936 chr22:19749961 TBX1 -0.33 -5.95 -0.31 6.85e-9 Inflammatory bowel disease; LUSC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.73 0.39 1.26e-13 Electroencephalogram traits; LUSC cis rs11098499 0.708 rs1546506 chr4:120241240 T/C cg24375607 chr4:120327624 NA 0.75 11.72 0.54 8.65e-27 Corneal astigmatism; LUSC cis rs7216064 0.532 rs3890640 chr17:66053028 C/T cg12091567 chr17:66097778 LOC651250 0.9 13.86 0.6 7.75e-35 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.41 0.5 3.56e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7681440 0.647 rs1372508 chr4:90819786 C/G cg15133208 chr4:90757351 SNCA 0.35 5.96 0.31 6.5e-9 Dementia with Lewy bodies; LUSC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg17376030 chr22:41985996 PMM1 0.48 6.02 0.31 4.55e-9 Vitiligo; LUSC cis rs17270561 0.583 rs7765833 chr6:25712433 C/A cg17691542 chr6:26056736 HIST1H1C 0.51 7.35 0.37 1.51e-12 Iron status biomarkers; LUSC cis rs7615952 0.800 rs13086460 chr3:125646417 C/T cg05084668 chr3:125655381 ALG1L -0.79 -11.93 -0.55 1.38e-27 Blood pressure (smoking interaction); LUSC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg24450063 chr1:156163899 SLC25A44 1.21 30.68 0.86 3.34e-99 Testicular germ cell tumor; LUSC cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg17366294 chr4:99064904 C4orf37 0.58 9.63 0.47 1.59e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg05623727 chr3:50126028 RBM5 0.31 5.73 0.3 2.2e-8 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg07362569 chr17:61921086 SMARCD2 0.37 7.27 0.37 2.5e-12 Prudent dietary pattern; LUSC cis rs934734 0.935 rs6711791 chr2:65579228 G/T cg08085232 chr2:65598271 SPRED2 -0.37 -5.85 -0.3 1.16e-8 Rheumatoid arthritis; LUSC cis rs559928 0.548 rs11231713 chr11:63931849 C/T cg24687543 chr11:63912206 MACROD1 0.47 5.82 0.3 1.4e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs1045714 0.895 rs4721867 chr7:2643352 A/G cg24848437 chr7:2645542 IQCE -0.62 -7.08 -0.36 8.51e-12 Urate levels in lean individuals; LUSC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg24110177 chr3:50126178 RBM5 0.64 11.28 0.53 3.1e-25 Body mass index; LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg10802521 chr3:52805072 NEK4 -0.54 -8.52 -0.42 5.74e-16 Bipolar disorder; LUSC cis rs4423214 0.840 rs1792233 chr11:71182179 G/A cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs72634258 0.786 rs7537362 chr1:8177564 C/T cg26816564 chr1:7831052 VAMP3 0.44 5.67 0.3 3.14e-8 Inflammatory bowel disease; LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg27170947 chr2:26402098 FAM59B 0.71 10.83 0.51 1.29e-23 Gut microbiome composition (summer); LUSC cis rs9463078 0.605 rs7763421 chr6:44877313 A/G cg25276700 chr6:44698697 NA 0.29 6.0 0.31 5.14e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg04414720 chr1:150670196 GOLPH3L -0.38 -5.8 -0.3 1.57e-8 Tonsillectomy; LUSC cis rs7100689 0.577 rs10749550 chr10:82031197 A/G cg01528321 chr10:82214614 TSPAN14 0.91 14.37 0.62 8.53e-37 Post bronchodilator FEV1; LUSC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs7089973 0.604 rs7915943 chr10:116618077 G/A cg25233709 chr10:116636983 FAM160B1 0.38 6.77 0.35 5.76e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6736093 0.931 rs7578435 chr2:112714751 G/A cg12686935 chr2:112915763 FBLN7 -0.36 -5.81 -0.3 1.45e-8 Coronary artery disease; LUSC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg09034736 chr1:150693464 HORMAD1 0.49 7.0 0.36 1.39e-11 Tonsillectomy; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4076764 0.522 rs10799914 chr1:163353205 A/G cg06092702 chr1:163392909 NA -0.35 -5.82 -0.3 1.35e-8 Motion sickness; LUSC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg09359103 chr1:154839909 KCNN3 -0.7 -15.74 -0.65 3.87e-42 Prostate cancer; LUSC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg20503657 chr10:835505 NA 0.78 9.42 0.46 7.61e-19 Eosinophil percentage of granulocytes; LUSC cis rs56283067 0.773 rs56115627 chr6:44683049 G/A cg20913747 chr6:44695427 NA -0.46 -7.68 -0.39 1.78e-13 Total body bone mineral density; LUSC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg18479299 chr3:125709523 NA -0.51 -5.74 -0.3 2.08e-8 Blood pressure (smoking interaction); LUSC cis rs4737010 0.570 rs10112594 chr8:41645565 C/T cg17182837 chr8:41585554 ANK1 -0.35 -6.29 -0.33 1.01e-9 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs983392 0.679 rs1026253 chr11:60030556 G/A cg24026212 chr11:59952134 MS4A6A 0.36 6.15 0.32 2.27e-9 Alzheimer's disease (late onset); LUSC cis rs7809950 1.000 rs6976607 chr7:107223401 A/C cg23024343 chr7:107201750 COG5 0.58 8.91 0.44 3.34e-17 Coronary artery disease; LUSC cis rs2832077 0.943 rs4816336 chr21:30193519 C/T cg08807101 chr21:30365312 RNF160 -0.53 -6.68 -0.34 9.85e-11 Cognitive test performance; LUSC cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.19 0.32 1.8e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg14893161 chr1:205819251 PM20D1 0.92 18.09 0.7 1.75e-51 Menarche (age at onset); LUSC cis rs7246967 0.611 rs35355374 chr19:22837701 C/T cg23217946 chr19:22817039 ZNF492 0.46 5.84 0.3 1.26e-8 Bronchopulmonary dysplasia; LUSC cis rs11105298 0.891 rs4842653 chr12:89834113 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -7.36 -0.37 1.4e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11031096 0.711 rs10767881 chr11:4205122 C/G cg18678763 chr11:4115507 RRM1 -0.42 -5.89 -0.31 9.46e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7598759 0.527 rs7571691 chr2:232369401 C/T cg19187155 chr2:232395269 NMUR1 0.89 15.68 0.65 6.4e-42 Noise-induced hearing loss; LUSC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg00933542 chr6:150070202 PCMT1 0.33 6.83 0.35 4.14e-11 Lung cancer; LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg22963979 chr7:1858916 MAD1L1 -0.47 -6.97 -0.36 1.71e-11 Bipolar disorder and schizophrenia; LUSC cis rs9929218 0.911 rs1075959 chr16:68832750 A/G cg02972257 chr16:68554789 NA 0.41 5.67 0.3 3.06e-8 Colorectal cancer; LUSC cis rs11608355 1.000 rs10774695 chr12:109868040 G/A cg05360138 chr12:110035743 NA 0.47 6.36 0.33 6.68e-10 Neuroticism; LUSC trans rs7829975 0.902 rs485107 chr8:8581408 C/G cg27411982 chr8:10470053 RP1L1 -0.38 -5.98 -0.31 5.88e-9 Mood instability; LUSC trans rs800082 0.668 rs9856190 chr3:144288547 G/C cg24215973 chr2:240111563 HDAC4 -0.61 -9.75 -0.47 6.19e-20 Smoking behavior; LUSC cis rs7572644 0.782 rs10185472 chr2:28151354 G/A cg27432699 chr2:27873401 GPN1 -0.53 -7.0 -0.36 1.41e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1577917 1.000 rs12199784 chr6:86726808 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.77e-10 Response to antipsychotic treatment; LUSC cis rs868036 0.609 rs13329413 chr15:68097126 C/T cg05925327 chr15:68127851 NA -0.48 -7.2 -0.37 4.12e-12 Restless legs syndrome; LUSC cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg21280719 chr6:42927975 GNMT -0.26 -5.71 -0.3 2.44e-8 Blood protein levels; LUSC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg27170947 chr2:26402098 FAM59B -0.62 -9.06 -0.44 1.13e-17 Gut microbiome composition (summer); LUSC cis rs4964805 0.505 rs4981032 chr12:104165864 C/T cg02344784 chr12:104178138 NT5DC3 0.38 6.05 0.31 3.94e-9 Attention deficit hyperactivity disorder; LUSC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg02951883 chr7:2050386 MAD1L1 0.53 9.84 0.47 3.24e-20 Bipolar disorder and schizophrenia; LUSC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg11742103 chr11:62369870 EML3;MTA2 0.55 8.99 0.44 1.9e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg25036284 chr2:26402008 FAM59B 0.77 10.9 0.51 7.17e-24 Gut microbiome composition (summer); LUSC cis rs9393777 0.920 rs41269265 chr6:27425349 T/C cg09904177 chr6:26538194 HMGN4 -0.77 -5.92 -0.31 8.13e-9 Intelligence (multi-trait analysis); LUSC cis rs921968 0.565 rs4672897 chr2:219588134 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.3 -0.49 8.75e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs7020830 0.931 rs1388978 chr9:37144062 G/T cg14294708 chr9:37120828 ZCCHC7 1.06 23.26 0.79 7.47e-72 Schizophrenia; LUSC trans rs11935423 0.778 rs28849180 chr4:100489995 C/T cg02164153 chr5:172068145 NEURL1B -0.47 -6.07 -0.32 3.51e-9 Gut microbiome composition (summer); LUSC cis rs7246657 1.000 rs7247672 chr19:37743928 A/G cg23950597 chr19:37808831 NA -0.61 -6.99 -0.36 1.53e-11 Coronary artery calcification; LUSC cis rs7119 0.717 rs10519167 chr15:77723027 G/T cg05673287 chr15:77411982 SGK269 -0.45 -7.24 -0.37 3.19e-12 Type 2 diabetes; LUSC cis rs295140 0.506 rs4673855 chr2:201136143 A/G cg04283868 chr2:201171347 SPATS2L 0.4 5.99 0.31 5.32e-9 QT interval; LUSC cis rs2219968 1.000 rs11783293 chr8:78958925 G/T cg00738934 chr8:78996279 NA 0.34 6.19 0.32 1.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg03188948 chr7:1209495 NA 0.43 6.35 0.33 6.96e-10 Longevity;Endometriosis; LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.07 -0.58 7.86e-32 Platelet count; LUSC trans rs2204008 0.805 rs7296063 chr12:37964775 T/G cg06521331 chr12:34319734 NA -0.4 -6.0 -0.31 5.24e-9 Bladder cancer; LUSC cis rs9287719 0.967 rs7600820 chr2:10740044 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17957827 chr17:79895524 PYCR1 -0.5 -6.01 -0.31 4.85e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg02782426 chr3:40428986 ENTPD3 0.34 6.26 0.32 1.2e-9 Renal cell carcinoma; LUSC trans rs7726839 0.507 rs60068988 chr5:597668 T/C cg11887960 chr12:57824829 NA 0.54 6.74 0.35 7.11e-11 Obesity-related traits; LUSC cis rs7909074 0.831 rs7903412 chr10:45382361 C/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.38 -0.42 1.49e-15 Mean corpuscular volume; LUSC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg03929089 chr4:120376271 NA -0.91 -14.23 -0.61 2.89e-36 Coronary artery disease; LUSC trans rs11098499 0.644 rs7693919 chr4:120540571 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.47 0.33 3.43e-10 Corneal astigmatism; LUSC cis rs7552167 0.925 rs4489498 chr1:24512055 A/G cg01960748 chr1:24522592 NA 0.68 10.62 0.5 6.67e-23 Psoriasis vulgaris; LUSC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg27129171 chr3:47204927 SETD2 -0.71 -11.97 -0.55 1.03e-27 Colorectal cancer; LUSC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg13126279 chr21:47581558 C21orf56 -0.48 -7.01 -0.36 1.32e-11 Testicular germ cell tumor; LUSC trans rs3808502 0.549 rs4841564 chr8:11425809 T/G cg11608241 chr8:8085544 FLJ10661 -0.46 -6.48 -0.33 3.34e-10 Neuroticism; LUSC cis rs4888262 0.604 rs12935075 chr16:74676033 A/T cg01733217 chr16:74700730 RFWD3 0.8 13.22 0.59 2.22e-32 Testicular germ cell tumor; LUSC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC trans rs194045 0.609 rs252344 chr16:29184882 G/A cg17334114 chr3:133646504 NA 0.54 6.76 0.35 6.05e-11 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs783147 0.500 rs9458016 chr6:161144800 A/G cg15416064 chr12:49209402 NA -0.43 -6.0 -0.31 5.11e-9 Lp (a) levels; LUSC cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg26384229 chr12:38710491 ALG10B 0.87 14.92 0.63 6.18e-39 Bladder cancer; LUSC cis rs453301 0.686 rs4840389 chr8:8884503 G/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.56 -0.38 3.95e-13 Joint mobility (Beighton score); LUSC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg18512352 chr11:47633146 NA -0.48 -10.02 -0.48 8.02e-21 Subjective well-being; LUSC cis rs2273669 0.588 rs12205061 chr6:109338161 T/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 8.89e-9 Prostate cancer; LUSC cis rs2324229 0.828 rs1180227 chr6:83951137 A/G cg08257003 chr6:84140564 ME1 -0.29 -6.89 -0.35 2.78e-11 Platelet-derived growth factor BB levels; LUSC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.18 16.89 0.68 1.07e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg13390004 chr1:15929781 NA 0.43 7.31 0.37 1.94e-12 Systolic blood pressure; LUSC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg00933542 chr6:150070202 PCMT1 0.33 7.09 0.36 8.11e-12 Lung cancer; LUSC cis rs8078723 0.866 rs7502514 chr17:38188844 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.41 6.5 0.33 3e-10 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs2386661 0.591 rs11255051 chr10:5653450 A/G cg11398623 chr21:37499189 NA 0.28 6.28 0.32 1.07e-9 Breast cancer; LUSC cis rs41271473 0.526 rs12143098 chr1:228720965 A/C cg16512390 chr1:228756714 NA 0.7 8.82 0.43 6.67e-17 Chronic lymphocytic leukemia; LUSC cis rs7408868 0.908 rs757474 chr19:15273624 T/C cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.1e-18 Pulse pressure; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 13.94 0.61 4.12e-35 Alzheimer's disease; LUSC cis rs7605827 0.930 rs1549017 chr2:15617017 T/C cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 6.24 0.32 1.34e-9 Personality dimensions; LUSC cis rs6681460 0.966 rs10889644 chr1:67145322 C/A cg02459107 chr1:67143332 SGIP1 0.46 8.63 0.43 2.55e-16 Presence of antiphospholipid antibodies; LUSC cis rs9467773 0.583 rs2498380 chr6:26643996 C/G cg09904177 chr6:26538194 HMGN4 -0.66 -11.95 -0.55 1.2100000000000001e-27 Intelligence (multi-trait analysis); LUSC cis rs17253792 0.822 rs77544029 chr14:56087917 T/C cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs7119 0.637 rs2667775 chr15:77864802 T/G cg27398640 chr15:77910606 LINGO1 0.35 7.87 0.4 5e-14 Type 2 diabetes; LUSC cis rs727505 0.954 rs66871687 chr7:124670475 A/G cg23710748 chr7:124431027 NA -0.4 -7.06 -0.36 9.86e-12 Lewy body disease; LUSC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs2482943 chr20:25380593 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.8 -17.21 -0.69 5.82e-48 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7312933 0.526 rs1669892 chr12:42811305 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.83 -0.35 4.12e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12541635 0.966 rs6469031 chr8:107048095 T/C cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.69e-20 Age of smoking initiation; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg00024416 chr22:24240387 NA -0.33 -5.77 -0.3 1.84e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs16895831 0.519 rs12196290 chr6:42552548 G/A cg10605015 chr6:42532144 UBR2 -0.49 -5.93 -0.31 7.49e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs965469 1.000 rs6051762 chr20:3321590 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.69 -0.3 2.84e-8 IFN-related cytopenia; LUSC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg11764359 chr7:65958608 NA -0.58 -8.99 -0.44 1.87e-17 Aortic root size; LUSC cis rs72960926 0.744 rs11759133 chr6:74932518 A/G cg03266952 chr6:74778945 NA -0.77 -6.79 -0.35 5.08e-11 Metabolite levels (MHPG); LUSC cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg24558204 chr6:135376177 HBS1L 0.68 10.47 0.5 2.25e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs17401966 0.522 rs17396973 chr1:10334924 C/T cg19773385 chr1:10388646 KIF1B -0.36 -6.3 -0.33 9.58e-10 Hepatocellular carcinoma; LUSC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg02951883 chr7:2050386 MAD1L1 -0.5 -8.68 -0.43 1.74e-16 Schizophrenia; LUSC cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -9.36 -0.46 1.24e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg00645731 chr22:42541494 CYP2D7P1 0.29 5.79 0.3 1.64e-8 Cognitive function; LUSC cis rs9815354 0.767 rs73081341 chr3:41900335 A/T cg03022575 chr3:42003672 ULK4 0.64 6.93 0.35 2.12e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs11209002 1.000 rs10749771 chr1:67573730 A/G cg02640540 chr1:67518911 SLC35D1 0.69 7.6 0.38 3e-13 Crohn's disease; LUSC trans rs4332037 0.624 rs73046339 chr7:1889300 G/A cg10840412 chr1:235813424 GNG4 0.45 6.01 0.31 4.74e-9 Bipolar disorder; LUSC cis rs17621444 0.522 rs10749342 chr10:121816910 C/T cg02041677 chr10:121771263 NA 0.34 6.42 0.33 4.61e-10 IgG glycosylation; LUSC cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg21252483 chr19:49399788 TULP2 -0.48 -6.77 -0.35 5.81e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs1670533 1.000 rs10026482 chr4:1051128 C/G cg16405210 chr4:1374714 KIAA1530 -0.46 -5.71 -0.3 2.44e-8 Recombination rate (females); LUSC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg07741184 chr6:167504864 NA -0.35 -6.37 -0.33 6.35e-10 Crohn's disease; LUSC cis rs6938 0.618 rs62029167 chr15:75228350 G/A cg10253484 chr15:75165896 SCAMP2 -0.48 -7.0 -0.36 1.38e-11 Breast cancer; LUSC cis rs2280018 0.526 rs2941257 chr16:15166445 T/C cg07549590 chr16:15018862 NA -0.59 -9.89 -0.48 2.15e-20 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7100689 0.784 rs10749562 chr10:82108253 G/T cg00277334 chr10:82204260 NA -0.52 -7.33 -0.37 1.74e-12 Post bronchodilator FEV1; LUSC cis rs4478137 0.501 rs28437702 chr4:164231410 C/T cg06758707 chr4:164254230 NPY1R -0.5 -6.79 -0.35 5.05e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2652822 0.584 rs1017546 chr15:63566702 G/T cg02713581 chr15:63449717 RPS27L -0.38 -5.99 -0.31 5.41e-9 Metabolic traits; LUSC cis rs1775715 0.870 rs1251400 chr10:32235145 A/G cg26784012 chr10:32216390 ARHGAP12 0.41 6.81 0.35 4.47e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg17264618 chr3:40429014 ENTPD3 0.36 7.48 0.38 6.5e-13 Renal cell carcinoma; LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg25428297 chr7:1022841 CYP2W1 0.29 6.24 0.32 1.34e-9 Longevity;Endometriosis; LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg16325326 chr1:53192061 ZYG11B -0.9 -16.97 -0.68 4.92e-47 Monocyte count; LUSC cis rs6964587 0.934 rs2961019 chr7:91572749 T/G cg17063962 chr7:91808500 NA -0.54 -8.17 -0.41 6.28e-15 Breast cancer; LUSC cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 6.01 0.31 4.76e-9 Rheumatoid arthritis; LUSC cis rs11155671 0.530 rs9397420 chr6:150206781 C/T cg07701084 chr6:150067640 NUP43 -0.45 -6.9 -0.35 2.59e-11 Testicular germ cell tumor; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg11062466 chr8:58055876 NA 0.65 8.39 0.42 1.41e-15 Developmental language disorder (linguistic errors); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg02899939 chr1:46016331 AKR1A1 0.46 6.16 0.32 2.05e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs11935423 0.735 rs7693979 chr4:100464565 A/T cg09996156 chr7:86688487 KIAA1324L -0.4 -5.95 -0.31 6.65e-9 Gut microbiome composition (summer); LUSC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg03709012 chr19:19516395 GATAD2A -0.83 -13.84 -0.6 9.33e-35 Tonsillectomy; LUSC cis rs7208859 0.573 rs7214313 chr17:29138596 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.69 0.34 9.14e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs965469 1.000 rs3310 chr20:3237232 C/T cg25506879 chr20:3388711 C20orf194 -0.56 -6.46 -0.33 3.81e-10 IFN-related cytopenia; LUSC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg03517284 chr6:25882590 NA 0.39 6.54 0.34 2.33e-10 Intelligence (multi-trait analysis); LUSC cis rs7903847 0.656 rs12218483 chr10:99141484 C/T cg20016023 chr10:99160130 RRP12 -0.28 -6.15 -0.32 2.17e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6723226 0.750 rs1033751 chr2:32695759 T/C cg02381751 chr2:32503542 YIPF4 0.54 8.29 0.41 2.78e-15 Intelligence (multi-trait analysis); LUSC cis rs9463078 0.790 rs1324531 chr6:45136224 T/C cg25276700 chr6:44698697 NA -0.28 -5.68 -0.3 3e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg02079420 chr8:82753780 SNX16 0.38 5.77 0.3 1.8e-8 Diastolic blood pressure; LUSC cis rs72781680 1.000 rs12623496 chr2:24181583 C/T cg20701182 chr2:24300061 SF3B14 0.58 6.2 0.32 1.71e-9 Lymphocyte counts; LUSC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg12311346 chr5:56204834 C5orf35 -0.95 -13.5 -0.59 1.97e-33 Initial pursuit acceleration; LUSC cis rs3770081 1.000 rs3810827 chr2:86334386 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.92 -0.35 2.37e-11 Facial emotion recognition (sad faces); LUSC cis rs763121 0.813 rs2179143 chr22:39037984 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.6 0.57 4.6e-30 Menopause (age at onset); LUSC cis rs6696846 0.765 rs11576867 chr1:205064676 C/T cg21643547 chr1:205240462 TMCC2 -0.41 -7.62 -0.38 2.7e-13 Red blood cell count; LUSC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg00166722 chr3:10149974 C3orf24 -0.57 -8.23 -0.41 4.28e-15 Alzheimer's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02567981 chr12:50101354 FMNL3 -0.41 -6.36 -0.33 6.6e-10 Electrocardiographic conduction measures; LUSC cis rs6681460 0.898 rs2483704 chr1:67195353 C/T cg02459107 chr1:67143332 SGIP1 -0.45 -8.14 -0.41 7.93e-15 Presence of antiphospholipid antibodies; LUSC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg00745463 chr17:30367425 LRRC37B -0.62 -7.68 -0.39 1.76e-13 Hip circumference adjusted for BMI; LUSC cis rs9837602 1.000 rs1021103 chr3:99603230 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.47 0.33 3.39e-10 Breast cancer; LUSC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg11764359 chr7:65958608 NA -0.78 -12.99 -0.58 1.6e-31 Aortic root size; LUSC cis rs727505 0.721 rs56069273 chr7:124768604 G/A cg23710748 chr7:124431027 NA -0.39 -6.96 -0.36 1.86e-11 Lewy body disease; LUSC cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg25208724 chr1:156163844 SLC25A44 1.04 18.46 0.71 6.1e-53 Testicular germ cell tumor; LUSC cis rs17685 0.753 rs1574107 chr7:75685047 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.66 -0.39 1.97e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg18350739 chr11:68623251 NA 0.4 7.15 0.36 5.43e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7829975 0.684 rs546603 chr8:8595838 T/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.57 -0.38 3.62e-13 Mood instability; LUSC trans rs7618501 0.572 rs4688756 chr3:50040194 T/A cg21659725 chr3:3221576 CRBN 0.63 10.51 0.5 1.62e-22 Intelligence (multi-trait analysis); LUSC cis rs1009647 1.000 rs1009647 chr14:55880047 G/A cg04306507 chr14:55594613 LGALS3 0.44 7.31 0.37 2.04e-12 Testicular germ cell tumor; LUSC cis rs868036 0.681 rs28688285 chr15:68110297 T/C cg08079166 chr15:68083412 MAP2K5 0.49 8.04 0.4 1.59e-14 Restless legs syndrome; LUSC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.82 -0.3 1.42e-8 Depression; LUSC cis rs7119 0.717 rs8032071 chr15:77745762 C/T cg27398640 chr15:77910606 LINGO1 0.29 5.88 0.31 1.01e-8 Type 2 diabetes; LUSC cis rs17253792 0.732 rs79014965 chr14:56117551 T/G cg01858014 chr14:56050164 KTN1 -0.8 -6.61 -0.34 1.56e-10 Putamen volume; LUSC cis rs354225 0.584 rs6739140 chr2:54823502 C/G cg01766943 chr2:54829624 SPTBN1 0.48 7.78 0.39 9.33e-14 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03933290 chr17:3717712 C17orf85 0.4 6.2 0.32 1.63e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11098499 0.743 rs11098501 chr4:120252017 T/G cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6942756 1.000 rs66970518 chr7:128871006 G/A cg02491457 chr7:128862824 NA -0.56 -7.98 -0.4 2.31e-14 White matter hyperintensity burden; LUSC cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg22618164 chr12:122356400 WDR66 -0.57 -8.52 -0.42 5.6e-16 Mean corpuscular volume; LUSC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.79e-9 Cannabis dependence symptom count; LUSC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg11645453 chr3:52864694 ITIH4 0.3 7.28 0.37 2.37e-12 Bipolar disorder; LUSC cis rs9300255 0.602 rs1790098 chr12:123655481 A/C cg13010344 chr12:123464640 ARL6IP4 -0.44 -6.04 -0.31 4.09e-9 Neutrophil percentage of white cells; LUSC cis rs17125944 0.505 rs75661138 chr14:53259262 G/A cg00686598 chr14:53173677 PSMC6 1.26 11.09 0.52 1.56e-24 Alzheimer's disease (late onset); LUSC cis rs9303401 0.646 rs9303403 chr17:57219300 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.44 -6.75 -0.35 6.75e-11 Cognitive test performance; LUSC trans rs10432489 0.708 rs4541220 chr2:181746466 A/G cg04744134 chr19:8408128 KANK3 -0.87 -6.65 -0.34 1.19e-10 QT interval; LUSC trans rs12579753 0.827 rs7311917 chr12:82187551 G/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.34 -0.33 7.66e-10 Resting heart rate; LUSC cis rs9359856 0.564 rs56396054 chr6:90360406 C/T cg13799429 chr6:90582589 CASP8AP2 -0.86 -8.63 -0.43 2.5e-16 Bipolar disorder; LUSC cis rs1372520 0.873 rs983361 chr4:90761944 T/G cg14346243 chr4:90757452 SNCA -0.42 -6.11 -0.32 2.78e-9 Neuroticism; LUSC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg16928487 chr17:17741425 SREBF1 0.44 8.71 0.43 1.42e-16 Total body bone mineral density; LUSC cis rs539096 0.540 rs37452 chr1:44297573 A/C cg12908607 chr1:44402522 ARTN -0.45 -7.22 -0.37 3.49e-12 Intelligence (multi-trait analysis); LUSC cis rs79911532 0.551 rs11553096 chr7:75677216 C/T cg03592824 chr7:75666768 STYXL1 0.7 6.83 0.35 4e-11 Mononucleosis; LUSC cis rs8018808 0.935 rs7146784 chr14:77932111 A/G cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg06112835 chr11:68658793 MRPL21 0.53 8.32 0.41 2.29e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg08045932 chr20:61659980 NA -0.53 -9.2 -0.45 3.88e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg11244672 chr19:19639970 YJEFN3 -0.55 -6.91 -0.35 2.49e-11 Bipolar disorder; LUSC cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg13175981 chr1:150552382 MCL1 0.43 6.06 0.31 3.71e-9 Tonsillectomy; LUSC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg11062466 chr8:58055876 NA 0.47 6.08 0.32 3.19e-9 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg23630131 chr7:65973040 NA -0.21 -6.0 -0.31 5.16e-9 Aortic root size; LUSC cis rs76878669 0.606 rs1785639 chr11:66100430 G/A cg18002602 chr11:66138449 SLC29A2 0.46 8.28 0.41 3.04e-15 Educational attainment (years of education); LUSC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg10253484 chr15:75165896 SCAMP2 -0.49 -7.37 -0.37 1.39e-12 Breast cancer; LUSC cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.48 -0.46 5.04e-19 Schizophrenia; LUSC cis rs4363385 0.510 rs11590835 chr1:153047166 T/C cg25856811 chr1:152973957 SPRR3 -0.39 -6.45 -0.33 3.93e-10 Inflammatory skin disease; LUSC cis rs11785400 1.000 rs10099892 chr8:143734608 C/T cg24634471 chr8:143751801 JRK 0.59 8.99 0.44 1.82e-17 Schizophrenia; LUSC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg18252515 chr7:66147081 NA 1.24 14.24 0.61 2.72e-36 Diabetic kidney disease; LUSC trans rs4811340 0.600 rs1474793 chr20:51177744 T/C cg15736553 chr3:11610338 VGLL4 -0.33 -5.96 -0.31 6.57e-9 Thyroid peroxidase antibody positivity; LUSC cis rs7267979 0.706 rs6037069 chr20:25234166 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.82 17.58 0.69 2.01e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.27e-11 Lung cancer; LUSC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.54 -7.96 -0.4 2.79e-14 Total body bone mineral density; LUSC cis rs30380 0.632 rs27434 chr5:96129512 A/G cg16492584 chr5:96139282 ERAP1 -0.53 -7.28 -0.37 2.44e-12 Cerebrospinal fluid biomarker levels; LUSC trans rs17039065 1.000 rs72889375 chr4:109387798 C/T cg07444054 chr2:108107501 NA 0.44 6.43 0.33 4.35e-10 Gut microbiome composition (summer); LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg11050988 chr7:1952600 MAD1L1 -0.32 -6.1 -0.32 2.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs78456975 0.943 rs6721243 chr2:1580250 A/G cg01028140 chr2:1542097 TPO -0.46 -6.53 -0.34 2.47e-10 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs7572644 0.766 rs4665398 chr2:28094770 A/T cg27432699 chr2:27873401 GPN1 0.52 6.47 0.33 3.5e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs926938 0.501 rs360686 chr1:115502524 C/T cg12756093 chr1:115239321 AMPD1 0.43 6.28 0.32 1.08e-9 Autism; LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 4.92e-10 Systemic lupus erythematosus; LUSC cis rs3126085 1.000 rs1858482 chr1:152306921 A/G cg26876637 chr1:152193138 HRNR 0.43 5.72 0.3 2.39e-8 Atopic dermatitis; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg02951883 chr7:2050386 MAD1L1 -0.4 -6.85 -0.35 3.66e-11 Bipolar disorder and schizophrenia; LUSC cis rs1153858 0.945 rs16943246 chr15:45720597 G/A cg26924012 chr15:45694286 SPATA5L1 1.1 17.52 0.69 3.41e-49 Homoarginine levels; LUSC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg23630131 chr7:65973040 NA -0.21 -5.71 -0.3 2.52e-8 Aortic root size; LUSC trans rs3808502 0.527 rs4410870 chr8:11156120 C/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.87 -0.35 3.12e-11 Neuroticism; LUSC cis rs10875595 0.775 rs66998469 chr5:140659960 T/C cg24830062 chr5:140700576 TAF7 -0.52 -6.39 -0.33 5.57e-10 Pulmonary function decline; LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.59e-29 Prudent dietary pattern; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg06876892 chr16:833231 MSLNL -0.26 -6.67 -0.34 1.09e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg26408565 chr15:76604113 ETFA -0.5 -8.01 -0.4 1.88e-14 Blood metabolite levels; LUSC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.52 0.38 4.98e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9486715 0.867 rs9384628 chr6:96960232 T/C cg06623918 chr6:96969491 KIAA0776 0.94 17.55 0.69 2.43e-49 Headache; LUSC cis rs7267979 0.932 rs1541061 chr20:25521057 G/A cg08601574 chr20:25228251 PYGB 0.39 5.96 0.31 6.48e-9 Liver enzyme levels (alkaline phosphatase); LUSC trans rs961253 0.501 rs6054145 chr20:6335730 T/C cg17788362 chr6:86352627 SYNCRIP 0.44 6.16 0.32 2.05e-9 Colorectal cancer; LUSC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg21433313 chr16:3507492 NAT15 -0.39 -6.22 -0.32 1.48e-9 Body mass index (adult); LUSC cis rs6665290 0.669 rs7552783 chr1:227174145 T/C cg10327440 chr1:227177885 CDC42BPA -1.11 -29.1 -0.85 1.35e-93 Myeloid white cell count; LUSC trans rs8072100 0.764 rs2644349 chr17:45641743 G/A cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.2e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg23029597 chr12:123009494 RSRC2 -0.72 -9.33 -0.45 1.51e-18 Body mass index; LUSC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg03060546 chr3:49711283 APEH 0.7 11.75 0.54 6.43e-27 Resting heart rate; LUSC cis rs834811 0.863 rs834821 chr7:135895713 A/T cg01726295 chr7:135938950 NA 0.35 6.19 0.32 1.77e-9 Post-traumatic stress disorder; LUSC cis rs713477 1.000 rs8014621 chr14:55906849 A/C cg13175173 chr14:55914753 NA -0.33 -6.84 -0.35 3.73e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs13385 0.769 rs28573694 chr5:139609951 T/G cg26211634 chr5:139558579 C5orf32 0.46 6.96 0.36 1.78e-11 Atrial fibrillation; LUSC cis rs13040088 0.935 rs62200158 chr20:61557906 C/T cg23096297 chr20:61557774 DIDO1 0.84 11.22 0.52 5.28e-25 Menopause (age at onset); LUSC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg27398817 chr8:82754497 SNX16 -0.46 -6.17 -0.32 1.96e-9 Diastolic blood pressure; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg16647868 chr5:131706066 SLC22A5 0.38 6.03 0.31 4.42e-9 Breast cancer; LUSC cis rs4663866 1.000 rs34897410 chr2:239182123 T/C cg16914508 chr2:239161102 PER2 0.68 7.21 0.37 3.7e-12 Irritable bowel syndrome; LUSC cis rs10465746 0.967 rs12407641 chr1:84368115 T/C cg10977910 chr1:84465055 TTLL7 0.43 6.16 0.32 2.07e-9 Obesity-related traits; LUSC cis rs1577917 0.771 rs2842607 chr6:86345039 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.0 -0.52 3.09e-24 Response to antipsychotic treatment; LUSC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg04267008 chr7:1944627 MAD1L1 -0.46 -6.87 -0.35 3.08e-11 Schizophrenia; LUSC cis rs9300255 0.602 rs1716164 chr12:123663660 G/A cg05973401 chr12:123451056 ABCB9 0.52 6.48 0.33 3.34e-10 Neutrophil percentage of white cells; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg07395648 chr5:131743802 NA -0.35 -5.77 -0.3 1.8e-8 Blood metabolite levels; LUSC cis rs2439831 0.702 rs8033995 chr15:44013509 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.79 0.43 7.99e-17 Lung cancer in ever smokers; LUSC cis rs7100689 0.646 rs1340376 chr10:82128963 A/G cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs68092024 0.731 rs792840 chr3:99471251 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 6.08 0.32 3.33e-9 Cleft lip with or without cleft palate; LUSC cis rs4423214 1.000 rs12419279 chr11:71139061 T/A cg05163923 chr11:71159392 DHCR7 0.66 9.73 0.47 7.55e-20 Vitamin D levels; LUSC cis rs78579285 0.544 rs11549835 chr16:88781073 G/A cg01900006 chr16:88814613 FAM38A 0.54 5.86 0.31 1.11e-8 Joint mobility (Beighton score); LUSC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg03713592 chr11:72463424 ARAP1 0.59 7.75 0.39 1.09e-13 Body mass index; LUSC cis rs6840360 0.806 rs13149588 chr4:152717757 C/T cg22705602 chr4:152727874 NA 0.27 5.71 0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg13256891 chr4:100009986 ADH5 -0.41 -5.66 -0.3 3.32e-8 Alcohol dependence; LUSC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg25072359 chr17:41440525 NA 0.63 9.2 0.45 3.95e-18 Menopause (age at onset); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg12843872 chr7:90894352 FZD1 0.47 5.97 0.31 5.99e-9 Cognitive function;Information processing speed; LUSC cis rs2273669 0.588 rs75995854 chr6:109325624 C/A cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg07677032 chr17:61819896 STRADA 0.52 8.61 0.43 2.91e-16 Prudent dietary pattern; LUSC cis rs929354 0.772 rs3802123 chr7:156970641 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.51 -0.46 3.83e-19 Body mass index; LUSC cis rs6542838 0.644 rs7590596 chr2:99467938 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.43 -5.75 -0.3 2.01e-8 Fear of minor pain; LUSC cis rs6701037 1.000 rs7512413 chr1:175124789 C/T cg00321850 chr1:175162397 KIAA0040 -0.4 -6.9 -0.35 2.55e-11 Alcohol dependence; LUSC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg21724239 chr8:58056113 NA 0.9 14.45 0.62 4.05e-37 Developmental language disorder (linguistic errors); LUSC cis rs4803468 1.000 rs2241709 chr19:41912250 C/T cg09537434 chr19:41945824 ATP5SL -0.9 -16.03 -0.66 2.63e-43 Height; LUSC cis rs7561273 0.586 rs11896092 chr2:24317827 G/A cg06627628 chr2:24431161 ITSN2 -0.52 -6.84 -0.35 3.89e-11 Quantitative traits; LUSC cis rs7617773 0.817 rs13094727 chr3:48323489 G/A cg11946769 chr3:48343235 NME6 0.87 13.75 0.6 2.09e-34 Coronary artery disease; LUSC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg09365446 chr1:150670422 GOLPH3L 0.45 6.72 0.34 8.04e-11 Melanoma; LUSC cis rs9811920 0.965 rs9849632 chr3:99867211 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.38 5.74 0.3 2.17e-8 Axial length; LUSC cis rs516243 0.807 rs578554 chr1:10741669 A/C cg02903756 chr1:10750680 CASZ1 -0.47 -8.29 -0.41 2.88e-15 Migraine - clinic-based; LUSC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg12463550 chr7:65579703 CRCP 0.47 6.96 0.36 1.86e-11 Aortic root size; LUSC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg11062466 chr8:58055876 NA 0.7 8.6 0.43 3.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs12928939 0.723 rs71403864 chr16:71695030 C/T cg03805757 chr16:71968109 PKD1L3 -0.39 -5.7 -0.3 2.68e-8 Post bronchodilator FEV1; LUSC cis rs7296418 0.961 rs10773921 chr12:123541606 C/T cg06742321 chr12:123595122 PITPNM2 0.38 5.7 0.3 2.69e-8 Platelet count; LUSC cis rs12545109 0.800 rs1440762 chr8:57410708 C/T cg09654669 chr8:57350985 NA -0.58 -7.88 -0.4 4.68e-14 Obesity-related traits; LUSC cis rs7582720 1.000 rs114899426 chr2:203771652 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.66 0.43 2.06e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06766273 chr11:62521983 ZBTB3 0.44 6.27 0.32 1.13e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg06850241 chr22:41845214 NA -0.31 -5.94 -0.31 7.11e-9 Vitiligo; LUSC cis rs9677476 0.818 rs62197333 chr2:232085049 G/C cg07929768 chr2:232055508 NA 0.34 6.55 0.34 2.21e-10 Food antigen IgG levels; LUSC cis rs2486288 0.586 rs12909883 chr15:45572054 G/C cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.9 -0.51 7.23e-24 Glomerular filtration rate; LUSC cis rs3125734 0.534 rs10821973 chr10:64052337 G/A cg09941381 chr10:64027924 RTKN2 -0.38 -6.96 -0.36 1.83e-11 Rheumatoid arthritis; LUSC cis rs4141404 0.787 rs11913992 chr22:31585220 G/A cg22777020 chr22:31556080 RNF185 -0.47 -6.8 -0.35 4.94e-11 Paclitaxel-induced neuropathy; LUSC cis rs35123781 1.000 rs2336880 chr5:139063728 A/G cg00976381 chr5:138713954 SLC23A1 0.39 6.03 0.31 4.44e-9 Schizophrenia; LUSC cis rs6456156 0.846 rs9364891 chr6:167516319 C/T cg07741184 chr6:167504864 NA -0.33 -5.88 -0.31 9.7e-9 Primary biliary cholangitis; LUSC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg16447950 chr5:562315 NA -0.52 -6.88 -0.35 3e-11 Obesity-related traits; LUSC cis rs11098499 0.738 rs34566984 chr4:120361270 G/A cg24375607 chr4:120327624 NA 0.79 11.77 0.54 5.27e-27 Corneal astigmatism; LUSC cis rs11190604 1.000 rs2495745 chr10:102329075 A/G cg16342193 chr10:102329863 NA -0.35 -6.57 -0.34 1.98e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11190604 1.000 rs2295774 chr10:102265847 A/C cg16342193 chr10:102329863 NA -0.36 -6.2 -0.32 1.64e-9 Palmitoleic acid (16:1n-7) levels; LUSC trans rs514406 0.895 rs1925673 chr1:53326984 T/G cg24643429 chr1:3562429 WDR8 0.33 6.04 0.31 4.2e-9 Monocyte count; LUSC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg15017067 chr4:17643749 FAM184B 0.36 5.9 0.31 8.95e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg02753203 chr1:228287806 NA -0.66 -11.14 -0.52 9.75e-25 Diastolic blood pressure; LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg08219700 chr8:58056026 NA 0.65 7.64 0.39 2.34e-13 Developmental language disorder (linguistic errors); LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg07332563 chr6:291687 DUSP22 -0.47 -6.82 -0.35 4.36e-11 Menopause (age at onset); LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.55 0.57 7.1e-30 Prudent dietary pattern; LUSC cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs939658 0.805 rs8036435 chr15:79420031 T/C cg17916960 chr15:79447300 NA -0.52 -10.31 -0.49 7.72e-22 Refractive error; LUSC cis rs6545883 0.931 rs778756 chr2:61781994 A/G cg15711740 chr2:61764176 XPO1 -0.44 -6.91 -0.35 2.47e-11 Tuberculosis; LUSC cis rs4891159 0.790 rs59762437 chr18:74153146 G/A cg24786174 chr18:74118243 ZNF516 -0.83 -15.21 -0.64 4.48e-40 Longevity; LUSC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg17764715 chr19:33622953 WDR88 0.63 9.31 0.45 1.78e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17270561 0.636 rs1575535 chr6:25809909 C/T cg17691542 chr6:26056736 HIST1H1C 0.48 6.77 0.35 5.88e-11 Iron status biomarkers; LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg08677398 chr8:58056175 NA 0.58 6.95 0.36 1.96e-11 Developmental language disorder (linguistic errors); LUSC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg17633681 chr16:88106987 BANP 0.49 9.07 0.44 1.03e-17 Menopause (age at onset); LUSC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.51 -0.38 5.35e-13 Aortic root size; LUSC cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.76 0.39 1.03e-13 Colorectal cancer; LUSC cis rs9790314 0.846 rs4290817 chr3:160967354 G/A cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 4.11e-20 Morning vs. evening chronotype; LUSC cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.34 0.46 1.39e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC cis rs7927771 0.507 rs1483988 chr11:47899030 C/T cg20307385 chr11:47447363 PSMC3 0.46 6.6 0.34 1.64e-10 Subjective well-being; LUSC cis rs921665 0.831 rs2305491 chr2:3198175 C/T cg16434511 chr2:3151078 NA -0.61 -6.64 -0.34 1.29e-10 World class endurance athleticism; LUSC cis rs12421382 0.659 rs11213103 chr11:109385935 A/G cg16359550 chr11:109292809 C11orf87 0.38 6.56 0.34 2e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.0 0.52 3.07e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs2996428 0.561 rs2275827 chr1:3746585 T/G cg23277830 chr1:3704460 LRRC47 0.31 5.8 0.3 1.52e-8 Red cell distribution width; LUSC cis rs4243830 0.850 rs10779790 chr1:6608435 A/G cg05709478 chr1:6581295 PLEKHG5 -0.49 -5.76 -0.3 1.9e-8 Body mass index; LUSC cis rs2404602 0.569 rs283793 chr15:76774752 G/A cg26408565 chr15:76604113 ETFA -0.39 -5.71 -0.3 2.49e-8 Blood metabolite levels; LUSC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.54 7.5 0.38 5.85e-13 Multiple sclerosis; LUSC cis rs4665809 0.652 rs7585891 chr2:26403766 G/A cg27170947 chr2:26402098 FAM59B -0.71 -10.67 -0.5 4.58e-23 Gut microbiome composition (summer); LUSC cis rs9467773 0.566 rs66972160 chr6:26359306 T/C cg05738196 chr6:26577821 NA -0.49 -7.55 -0.38 4.21e-13 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg25258033 chr6:167368657 RNASET2 0.48 7.92 0.4 3.52e-14 Crohn's disease; LUSC trans rs6480314 0.542 rs10998045 chr10:70029383 T/C cg04882175 chr6:131122610 NA -0.55 -6.32 -0.33 8.4e-10 Optic nerve measurement (disc area); LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg24060327 chr5:131705240 SLC22A5 -0.53 -8.78 -0.43 8.66e-17 Acylcarnitine levels; LUSC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg21984481 chr17:79567631 NPLOC4 0.74 15.67 0.65 7.08e-42 Eye color traits; LUSC cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.13 -0.36 6.41e-12 Menopause (age at onset); LUSC cis rs6598955 0.671 rs12116908 chr1:26587918 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs1387259 0.931 rs11168474 chr12:48621384 A/C cg04545296 chr12:48745243 ZNF641 0.34 6.22 0.32 1.47e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg10664184 chr19:17420304 DDA1 0.48 6.22 0.32 1.45e-9 Systemic lupus erythematosus; LUSC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg12560992 chr17:57184187 TRIM37 -0.84 -15.4 -0.64 8.19e-41 Intelligence (multi-trait analysis); LUSC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg17507749 chr15:85114479 UBE2QP1 0.69 8.78 0.43 8.54e-17 Schizophrenia; LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.26 0.32 1.2e-9 Menopause (age at onset); LUSC cis rs17125944 0.505 rs77949716 chr14:53204234 G/A cg00686598 chr14:53173677 PSMC6 1.14 10.28 0.49 1e-21 Alzheimer's disease (late onset); LUSC cis rs9039 1.000 rs12924275 chr16:9191790 C/T cg08831531 chr16:9218945 NA -0.69 -10.39 -0.49 4.16e-22 Menopause (age at onset); LUSC trans rs9375185 0.941 rs9401599 chr6:123120403 C/T cg21773220 chr11:94883919 NA -0.57 -6.42 -0.33 4.58e-10 Cerebrospinal fluid biomarker levels; LUSC cis rs13315871 0.929 rs9854438 chr3:58277327 G/A cg20936604 chr3:58311152 NA -0.7 -6.72 -0.35 7.91e-11 Cholesterol, total; LUSC trans rs225245 0.817 rs1049379 chr17:33998802 G/C cg19694781 chr19:47549865 TMEM160 -0.41 -6.42 -0.33 4.71e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs35146811 0.700 rs7788301 chr7:99782753 C/G cg22906224 chr7:99728672 NA 0.47 6.54 0.34 2.36e-10 Coronary artery disease; LUSC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.18e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9814567 1.000 rs7371896 chr3:134249769 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.25 -0.59 1.75e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg23887609 chr12:130822674 PIWIL1 0.49 7.25 0.37 2.87e-12 Menopause (age at onset); LUSC cis rs12220238 1.000 rs12220238 chr10:75952670 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.61 0.34 1.48e-10 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg15704280 chr7:45808275 SEPT13 -0.85 -14.27 -0.62 2.04e-36 Height; LUSC cis rs9326248 0.539 rs10892058 chr11:116876621 C/T cg20608306 chr11:116969690 SIK3 0.34 6.33 0.33 7.77e-10 Blood protein levels; LUSC cis rs3008870 0.755 rs1925410 chr1:67365230 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.8 -13.22 -0.59 2.22e-32 Lymphocyte percentage of white cells; LUSC cis rs7246657 0.943 rs2081096 chr19:37964700 G/A cg23950597 chr19:37808831 NA -0.63 -7.56 -0.38 4.01e-13 Coronary artery calcification; LUSC cis rs6121246 0.609 rs6087783 chr20:30421224 T/G cg13852791 chr20:30311386 BCL2L1 0.9 13.36 0.59 6.74e-33 Mean corpuscular hemoglobin; LUSC cis rs1801251 1.000 rs283480 chr2:233648742 G/A cg08000102 chr2:233561755 GIGYF2 0.75 11.78 0.54 4.88e-27 Coronary artery disease; LUSC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.11 -0.41 1.01e-14 Intelligence (multi-trait analysis); LUSC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg11742103 chr11:62369870 EML3;MTA2 0.55 8.99 0.44 1.9e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs4975709 0.838 rs4975753 chr5:1880865 T/C cg15595755 chr5:1867978 NA 0.4 6.3 0.33 9.41e-10 Cardiovascular disease risk factors; LUSC cis rs921665 0.831 rs2167961 chr2:3177617 C/G cg16434511 chr2:3151078 NA -0.63 -6.74 -0.35 7.07e-11 World class endurance athleticism; LUSC cis rs3820928 0.874 rs4675128 chr2:227814757 T/C cg11843606 chr2:227700838 RHBDD1 -0.54 -8.0 -0.4 2.11e-14 Pulmonary function; LUSC cis rs6840360 1.000 rs12331037 chr4:152663971 G/A cg22705602 chr4:152727874 NA -0.28 -6.0 -0.31 5.06e-9 Intelligence (multi-trait analysis); LUSC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg06238570 chr21:40685208 BRWD1 -0.53 -8.21 -0.41 4.79e-15 Menarche (age at onset); LUSC cis rs2230307 0.536 rs564938 chr1:100592901 T/C cg24955406 chr1:100503596 HIAT1 -0.59 -6.07 -0.32 3.47e-9 Carotid intima media thickness; LUSC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg08280861 chr8:58055591 NA 0.53 6.18 0.32 1.86e-9 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.954 rs12507964 chr4:120413061 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.58 0.34 1.81e-10 Corneal astigmatism; LUSC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs546131 0.963 rs539044 chr11:34841542 G/T cg11058730 chr11:34937778 PDHX;APIP 0.46 6.37 0.33 6.36e-10 Lung disease severity in cystic fibrosis; LUSC cis rs34891900 0.507 rs738133 chr22:18205557 C/T cg08824373 chr22:18117835 NA -0.41 -6.2 -0.32 1.66e-9 Sum neutrophil eosinophil counts; LUSC cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.02 -0.4 1.85e-14 Lung cancer; LUSC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.06 -0.48 5.7e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg11941060 chr3:133502564 NA 0.41 6.03 0.31 4.33e-9 Iron status biomarkers; LUSC cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg09025071 chr16:1593152 IFT140;TMEM204 0.32 7.04 0.36 1.1e-11 Coronary artery disease; LUSC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg24209194 chr3:40518798 ZNF619 0.45 5.94 0.31 7.21e-9 Renal cell carcinoma; LUSC trans rs561341 0.883 rs6505274 chr17:30344581 G/T cg20587970 chr11:113659929 NA -1.05 -14.68 -0.63 5.31e-38 Hip circumference adjusted for BMI; LUSC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.28 -0.32 1.06e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 13.02 0.58 1.24e-31 Hip circumference adjusted for BMI; LUSC cis rs6060960 0.537 rs75351461 chr20:30458612 C/T cg13852791 chr20:30311386 BCL2L1 0.59 6.41 0.33 4.99e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9308433 0.529 rs4655244 chr1:214497580 A/G cg06198575 chr1:214491504 SMYD2 0.45 7.06 0.36 9.75e-12 IgG glycosylation; LUSC cis rs7953249 0.618 rs7954039 chr12:121398654 A/C cg02403541 chr12:121454288 C12orf43 -0.72 -11.01 -0.52 2.86e-24 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg16006841 chr5:176797999 RGS14 0.62 9.83 0.47 3.3e-20 Hemoglobin concentration;Hematocrit; LUSC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg20135002 chr11:47629003 NA 0.49 7.76 0.39 1.05e-13 Subjective well-being; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg07332563 chr6:291687 DUSP22 0.71 12.0 0.55 7.99e-28 Menopause (age at onset); LUSC cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg11584989 chr19:19387371 SF4 -0.52 -6.16 -0.32 2.05e-9 Bipolar disorder; LUSC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg06022373 chr22:39101656 GTPBP1 0.76 11.63 0.54 1.77e-26 Menopause (age at onset); LUSC cis rs9650315 0.929 rs6474054 chr8:57169889 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs6964587 1.000 rs2282970 chr7:91584281 A/G cg01689657 chr7:91764605 CYP51A1 0.31 5.8 0.3 1.57e-8 Breast cancer; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg23131131 chr22:24373011 LOC391322 -0.51 -7.52 -0.38 5.06e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs950776 0.518 rs952216 chr15:78819202 C/T cg06917634 chr15:78832804 PSMA4 0.82 14.78 0.63 2.27e-38 Sudden cardiac arrest; LUSC cis rs939658 0.728 rs11637459 chr15:79413554 A/G cg17916960 chr15:79447300 NA -0.5 -9.52 -0.46 3.58e-19 Refractive error; LUSC cis rs6456156 0.528 rs6936261 chr6:167469676 A/C cg07741184 chr6:167504864 NA 0.4 7.01 0.36 1.3e-11 Primary biliary cholangitis; LUSC trans rs2228479 0.850 rs11645240 chr16:89837326 T/C cg24644049 chr4:85504048 CDS1 0.86 7.56 0.38 3.83e-13 Skin colour saturation; LUSC cis rs6681460 0.934 rs10889635 chr1:67075575 G/A cg02459107 chr1:67143332 SGIP1 0.48 8.82 0.43 6.45e-17 Presence of antiphospholipid antibodies; LUSC cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg23583168 chr7:148888333 NA -0.76 -12.32 -0.56 5.16e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9300255 0.537 rs1790101 chr12:123704844 T/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg16743903 chr16:89593216 SPG7 0.38 6.04 0.31 4.06e-9 Multiple myeloma (IgH translocation); LUSC cis rs939658 1.000 rs8031504 chr15:79458589 G/T cg17916960 chr15:79447300 NA 0.48 9.5 0.46 4.16e-19 Refractive error; LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg10729496 chr3:10149963 C3orf24 0.59 8.04 0.4 1.61e-14 Alzheimer's disease; LUSC cis rs7539542 0.536 rs12091234 chr1:202855508 C/T cg19681188 chr1:202830198 LOC148709 0.41 6.02 0.31 4.48e-9 Mean platelet volume; LUSC cis rs7949030 0.653 rs2516634 chr11:62367186 G/A cg22862634 chr11:62369728 EML3;MTA2 -0.59 -9.63 -0.47 1.6e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11190604 1.000 rs2489040 chr10:102331298 G/A cg16342193 chr10:102329863 NA -0.37 -6.77 -0.35 5.79e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.79 -0.39 8.48e-14 Chronic sinus infection; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg24503407 chr1:205819492 PM20D1 0.53 8.56 0.42 4.3e-16 Menarche (age at onset); LUSC cis rs12134245 0.874 rs34842487 chr1:92021611 C/T cg25838465 chr1:92012736 NA -0.56 -10.12 -0.48 3.62e-21 Breast cancer; LUSC cis rs793571 0.544 rs1427282 chr15:58914326 C/T cg05156742 chr15:59063176 FAM63B 0.54 8.22 0.41 4.56e-15 Schizophrenia; LUSC cis rs1451375 0.617 rs2876829 chr7:50566762 A/G cg18232548 chr7:50535776 DDC 0.54 7.63 0.39 2.51e-13 Malaria; LUSC cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg01849466 chr14:104193079 ZFYVE21 0.57 8.93 0.44 2.83e-17 Schizophrenia; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg11060661 chr22:24314208 DDT;DDTL 0.5 8.18 0.41 5.81e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs116988415 0.584 rs4899145 chr14:65241867 G/A cg00114569 chr14:65239327 SPTB 0.66 6.4 0.33 5.23e-10 Daytime sleep phenotypes; LUSC cis rs2901656 0.583 rs6702667 chr1:172400484 A/C cg03748243 chr1:172413542 C1orf105;PIGC 0.3 6.25 0.32 1.28e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs62408225 0.748 rs7744528 chr6:90916931 C/G cg06866423 chr6:90926672 BACH2 0.4 6.32 0.33 8.41e-10 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg11764359 chr7:65958608 NA 0.74 11.82 0.54 3.58e-27 Aortic root size; LUSC cis rs2285947 1.000 rs2285950 chr7:21584432 C/T cg04471919 chr7:21584483 DNAH11 -0.37 -8.55 -0.42 4.49e-16 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs12545109 0.800 rs1371936 chr8:57422715 A/G cg09654669 chr8:57350985 NA -0.51 -6.6 -0.34 1.61e-10 Obesity-related traits; LUSC cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg06454157 chr6:167490870 NA -0.27 -6.16 -0.32 2.06e-9 Crohn's disease; LUSC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg11645453 chr3:52864694 ITIH4 0.57 13.75 0.6 2.19e-34 Schizophrenia; LUSC cis rs12618769 0.652 rs3769698 chr2:99233894 T/C cg10123293 chr2:99228465 UNC50 0.47 7.57 0.38 3.62e-13 Bipolar disorder; LUSC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.85 0.3 1.2e-8 Lung cancer; LUSC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.85 -0.3 1.17e-8 Depression; LUSC cis rs7917772 0.582 rs7899004 chr10:104341435 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.68 -10.94 -0.51 5.16e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4795519 0.569 rs2176132 chr17:22185887 T/C cg22648282 chr17:21454238 C17orf51 -0.44 -5.92 -0.31 8.14e-9 Chronic myeloid leukemia; LUSC cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg12826209 chr6:26865740 GUSBL1 0.48 6.17 0.32 1.97e-9 Intelligence (multi-trait analysis); LUSC cis rs4285028 0.747 rs1127412 chr3:121414061 C/T cg11130432 chr3:121712080 ILDR1 -0.56 -8.41 -0.42 1.18e-15 Multiple sclerosis; LUSC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg09658497 chr7:2847517 GNA12 -0.37 -6.19 -0.32 1.74e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs9303401 0.659 rs12602808 chr17:56698420 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.55e-35 Cognitive test performance; LUSC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg26850624 chr5:429559 AHRR -0.33 -5.88 -0.31 1.01e-8 Cystic fibrosis severity; LUSC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg26597838 chr10:835615 NA 0.74 8.74 0.43 1.18e-16 Eosinophil percentage of granulocytes; LUSC cis rs7712401 0.715 rs6862366 chr5:122360158 G/C cg19077854 chr5:122220652 SNX24 -0.41 -8.99 -0.44 1.9e-17 Mean platelet volume; LUSC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg09509183 chr1:209979624 IRF6 0.5 5.71 0.3 2.55e-8 Cleft lip with or without cleft palate; LUSC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.83 0.35 4.01e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7191700 0.509 rs415595 chr16:11363692 A/G cg00044050 chr16:11439710 C16orf75 0.62 10.48 0.5 2.17e-22 Multiple sclerosis; LUSC cis rs3096299 0.504 rs4785574 chr16:89568875 A/G cg02034447 chr16:89574710 SPG7 0.39 5.82 0.3 1.39e-8 Multiple myeloma (IgH translocation); LUSC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg18876405 chr7:65276391 NA -0.55 -8.77 -0.43 9.25e-17 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17231661 chr11:119039801 NLRX1 -0.41 -6.41 -0.33 5.01e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7586879 0.559 rs13387729 chr2:25076126 A/G cg15423357 chr2:25149977 NA 0.33 6.36 0.33 6.73e-10 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24616795 chr3:53032891 SFMBT1 0.42 6.29 0.33 9.84e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs34779708 0.931 rs2148482 chr10:35348910 A/G cg04310649 chr10:35416472 CREM -0.44 -6.84 -0.35 3.85e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4730250 0.707 rs257381 chr7:106803963 T/C cg02696742 chr7:106810147 HBP1 -0.63 -8.89 -0.44 4.03e-17 Osteoarthritis; LUSC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg02951883 chr7:2050386 MAD1L1 -0.4 -7.0 -0.36 1.45e-11 Schizophrenia; LUSC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg12963246 chr6:28129442 ZNF389 0.52 7.16 0.36 5.3e-12 Depression; LUSC trans rs17685 0.753 rs7804598 chr7:75702578 C/T cg19862616 chr7:65841803 NCRNA00174 1.11 18.94 0.72 7.6e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6430585 0.583 rs6728946 chr2:136635343 C/G cg07169764 chr2:136633963 MCM6 1.23 19.46 0.73 6.2e-57 Corneal structure; LUSC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg03709012 chr19:19516395 GATAD2A 0.84 14.17 0.61 5.3e-36 Tonsillectomy; LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg24675658 chr1:53192096 ZYG11B -0.53 -8.33 -0.41 2.18e-15 Monocyte count; LUSC cis rs11098499 0.866 rs6824111 chr4:120285968 T/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20372048 chr12:82752172 CCDC59;C12orf26 0.43 6.02 0.31 4.69e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7726839 0.561 rs56410216 chr5:583216 C/A cg11887960 chr12:57824829 NA 0.48 6.47 0.33 3.46e-10 Obesity-related traits; LUSC cis rs240764 0.853 rs12190903 chr6:100983505 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.31 -0.33 8.88e-10 Neuroticism; LUSC cis rs9549260 0.753 rs4943794 chr13:41173408 G/C cg21288729 chr13:41239152 FOXO1 0.53 5.99 0.31 5.38e-9 Red blood cell count; LUSC cis rs9611519 1.000 rs2273085 chr22:41615376 C/T cg13813247 chr22:41461852 NA -0.34 -6.08 -0.32 3.28e-9 Neuroticism; LUSC cis rs4969178 0.965 rs16971107 chr17:76394042 C/T cg20026190 chr17:76395443 PGS1 0.45 8.1 0.41 1.06e-14 HDL cholesterol levels; LUSC cis rs11098499 0.739 rs7441137 chr4:120133221 G/T cg24375607 chr4:120327624 NA -0.69 -10.9 -0.51 6.88e-24 Corneal astigmatism; LUSC cis rs569214 0.763 rs484377 chr8:27477509 C/T cg00839333 chr8:27504520 SCARA3 0.34 5.77 0.3 1.8e-8 Alzheimer's disease; LUSC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg27427491 chr17:78079615 GAA -0.36 -6.94 -0.36 2.03e-11 Yeast infection; LUSC cis rs9660992 0.736 rs72745207 chr1:205251991 C/G cg21545522 chr1:205238299 TMCC2 0.51 9.47 0.46 5.39e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.79 7.51 0.38 5.59e-13 Cerebrospinal P-tau181p levels; LUSC cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -13.58 -0.6 9.78e-34 Extrinsic epigenetic age acceleration; LUSC cis rs2267137 0.868 rs174770 chr22:29766895 C/T cg07256473 chr22:29710276 RASL10A 0.38 7.35 0.37 1.54e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg14004847 chr7:1930337 MAD1L1 -0.46 -6.78 -0.35 5.59e-11 Bipolar disorder and schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14765172 chr6:153304972 FBXO5 -0.42 -6.03 -0.31 4.29e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC cis rs9311676 0.632 rs7624283 chr3:58369897 G/A cg26110898 chr3:58419937 PDHB 0.42 6.72 0.35 7.93e-11 Systemic lupus erythematosus; LUSC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg10802521 chr3:52805072 NEK4 -0.52 -8.19 -0.41 5.8e-15 Intelligence (multi-trait analysis); LUSC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.3 -5.69 -0.3 2.76e-8 Schizophrenia; LUSC cis rs7937682 1.000 rs4936661 chr11:111587495 G/A cg22437258 chr11:111473054 SIK2 -0.47 -6.06 -0.31 3.57e-9 Primary sclerosing cholangitis; LUSC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg24690094 chr11:67383802 NA 0.54 11.24 0.52 4.64e-25 Mean corpuscular volume; LUSC trans rs9329221 0.537 rs12678797 chr8:9978919 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.14 -0.32 2.39e-9 Neuroticism; LUSC cis rs7223966 1.000 rs9908044 chr17:61747032 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 7.33 0.37 1.75e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs16910800 1.000 rs2468647 chr11:23202054 C/T cg20040320 chr11:23191996 NA 0.44 6.47 0.33 3.59e-10 Cancer; LUSC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg02772935 chr3:125709198 NA -0.48 -5.82 -0.3 1.36e-8 Blood pressure (smoking interaction); LUSC cis rs9394152 0.781 rs9380362 chr6:33467734 T/C cg13560919 chr6:33536144 NA 0.61 10.76 0.51 2.23e-23 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22948335 chr2:70475902 TIA1 -0.43 -6.39 -0.33 5.56e-10 Electrocardiographic conduction measures; LUSC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg24110177 chr3:50126178 RBM5 -0.54 -8.74 -0.43 1.19e-16 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.04 -16.0 -0.66 3.52e-43 Gut microbiome composition (summer); LUSC cis rs34779708 0.931 rs35848945 chr10:35287561 G/T cg03585969 chr10:35415529 CREM 0.6 8.53 0.42 5.07e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6582630 0.502 rs4379906 chr12:38295673 G/A cg26384229 chr12:38710491 ALG10B 0.88 14.94 0.63 5.21e-39 Drug-induced liver injury (flucloxacillin); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01252224 chr16:83841660 HSBP1 -0.41 -5.97 -0.31 6.03e-9 Electrocardiographic conduction measures; LUSC cis rs9287719 0.967 rs963831 chr2:10745184 T/C cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs11024102 0.962 rs12575487 chr11:17019317 C/T cg15084286 chr11:17036142 PLEKHA7 0.46 6.16 0.32 2.09e-9 Glaucoma (primary angle closure); LUSC cis rs6964587 1.000 rs6952389 chr7:91657994 A/G cg22117172 chr7:91764530 CYP51A1 0.31 5.7 0.3 2.7e-8 Breast cancer; LUSC cis rs7582720 0.832 rs115194657 chr2:203829284 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg24675658 chr1:53192096 ZYG11B 0.72 11.91 0.55 1.75e-27 Monocyte count; LUSC cis rs11828289 0.660 rs76379912 chr11:23182498 A/G cg20040320 chr11:23191996 NA -0.58 -6.09 -0.32 3.1e-9 Cancer; LUSC cis rs3808502 0.527 rs2736389 chr8:11161310 C/A cg21775007 chr8:11205619 TDH 0.48 6.85 0.35 3.49e-11 Neuroticism; LUSC cis rs12928939 0.517 rs17358402 chr16:71967927 C/T cg03805757 chr16:71968109 PKD1L3 -0.64 -9.8 -0.47 4.31e-20 Post bronchodilator FEV1; LUSC cis rs11250464 0.833 rs11250466 chr10:1409378 C/T cg26394196 chr10:1453818 ADARB2 -0.38 -6.52 -0.34 2.63e-10 Radiation response; LUSC cis rs3820928 0.874 rs10174073 chr2:227794944 A/G cg11843606 chr2:227700838 RHBDD1 -0.55 -7.98 -0.4 2.34e-14 Pulmonary function; LUSC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.24 0.52 4.42e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg05368731 chr17:41323189 NBR1 0.92 15.52 0.65 2.79e-41 Menopause (age at onset); LUSC cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.4 -0.46 9.12e-19 Chronic sinus infection; LUSC cis rs9486719 0.947 rs2472908 chr6:96875998 A/T cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23429847 chr5:128430259 ISOC1 0.53 7.33 0.37 1.78e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6504340 0.741 rs34490194 chr17:46648744 C/T cg09704116 chr17:46666958 LOC404266 -0.37 -6.26 -0.32 1.22e-9 Primary tooth development (number of teeth); LUSC trans rs7980799 0.649 rs2084391 chr12:33655419 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.01 -0.4 1.92e-14 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg13531842 chr10:38383804 ZNF37A -0.45 -7.01 -0.36 1.34e-11 Extrinsic epigenetic age acceleration; LUSC cis rs9815354 0.812 rs58442057 chr3:41827209 G/A cg03022575 chr3:42003672 ULK4 0.85 8.62 0.43 2.78e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg09877947 chr5:131593287 PDLIM4 -0.43 -6.76 -0.35 6.16e-11 Breast cancer; LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7246657 0.943 rs10417503 chr19:37842735 T/C cg23950597 chr19:37808831 NA -0.63 -7.68 -0.39 1.82e-13 Coronary artery calcification; LUSC cis rs9816226 1.000 rs55835921 chr3:185831474 T/C cg00760338 chr3:185826511 ETV5 -0.68 -8.79 -0.43 7.94e-17 Obesity;Body mass index; LUSC cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg15309053 chr8:964076 NA -0.34 -6.89 -0.35 2.86e-11 Schizophrenia; LUSC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg05738196 chr6:26577821 NA 0.52 8.3 0.41 2.53e-15 Schizophrenia; LUSC trans rs6598955 0.617 rs11247895 chr1:26599542 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.61 -8.53 -0.42 5.13e-16 Obesity-related traits; LUSC cis rs1348850 0.526 rs4243389 chr2:178379783 G/C cg22681709 chr2:178499509 PDE11A -0.46 -6.8 -0.35 4.7e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg19468946 chr17:37922297 IKZF3 -0.43 -6.89 -0.35 2.82e-11 Self-reported allergy; LUSC cis rs1178968 0.818 rs2528709 chr7:72788457 C/A cg25889504 chr7:72793014 NA 0.57 7.43 0.38 9.39e-13 Triglyceride levels; LUSC cis rs7246967 0.673 rs16999580 chr19:22923487 C/T cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC trans rs8073060 0.586 rs4795086 chr17:34042190 G/A cg19694781 chr19:47549865 TMEM160 1.14 18.04 0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.78 0.54 5.2e-27 Prudent dietary pattern; LUSC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg21862992 chr11:68658383 NA 0.48 7.74 0.39 1.17e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs503341 0.756 rs11231591 chr11:63587986 G/T cg04362095 chr11:63592001 C11orf84 -0.58 -8.9 -0.44 3.5e-17 Pulse pressure; LUSC cis rs7208859 0.623 rs28433704 chr17:29084285 G/C cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg05025164 chr4:1340916 KIAA1530 -0.67 -10.43 -0.5 3.15e-22 Longevity; LUSC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg10356904 chr22:49881777 NA -0.33 -7.52 -0.38 5.24e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs6722750 0.967 rs17754672 chr2:64400608 A/G cg22352474 chr2:64371530 PELI1 -0.58 -8.77 -0.43 8.99e-17 Neuroticism; LUSC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg12963246 chr6:28129442 ZNF389 0.55 7.74 0.39 1.17e-13 Parkinson's disease; LUSC cis rs3126085 0.696 rs41266112 chr1:152185762 C/G cg26876637 chr1:152193138 HRNR 0.44 6.13 0.32 2.46e-9 Atopic dermatitis; LUSC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg00933542 chr6:150070202 PCMT1 0.32 6.59 0.34 1.74e-10 Lung cancer; LUSC trans rs330071 0.686 rs4841139 chr8:9249210 C/T cg21775007 chr8:11205619 TDH 0.42 6.16 0.32 2.11e-9 Acne (severe); LUSC cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg23796481 chr11:64053134 BAD;GPR137 0.6 9.89 0.48 2.12e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7527798 0.637 rs7515149 chr1:207838352 T/G cg09232269 chr1:207846808 CR1L -0.3 -6.3 -0.33 9.27e-10 Erythrocyte sedimentation rate; LUSC cis rs807669 0.777 rs9605972 chr22:19253274 C/T cg02655711 chr22:19163373 SLC25A1 0.74 15.13 0.64 9.36e-40 Metabolite levels; LUSC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg00033643 chr7:134001901 SLC35B4 0.43 6.35 0.33 7.2e-10 Mean platelet volume; LUSC cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.37 0.56 3.34e-29 Colorectal cancer; LUSC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg04944784 chr2:26401820 FAM59B -0.68 -9.39 -0.46 9.82e-19 Gut microbiome composition (summer); LUSC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg05738196 chr6:26577821 NA -0.47 -6.86 -0.35 3.27e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs17818399 0.749 rs13000560 chr2:46790997 G/T cg21681030 chr2:46777652 RHOQ 0.45 6.34 0.33 7.36e-10 Height; LUSC cis rs9326248 0.861 rs7120309 chr11:117042816 T/A cg01368799 chr11:117014884 PAFAH1B2 0.46 5.66 0.3 3.2e-8 Blood protein levels; LUSC cis rs34779708 0.931 rs10437420 chr10:35335044 A/C cg04310649 chr10:35416472 CREM 0.41 6.32 0.33 8.57e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9467711 0.606 rs2393667 chr6:26421345 T/C cg09904177 chr6:26538194 HMGN4 -0.74 -6.85 -0.35 3.47e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs2274273 0.588 rs9919932 chr14:55814080 A/G cg04306507 chr14:55594613 LGALS3 0.48 9.46 0.46 5.53e-19 Protein biomarker; LUSC cis rs9902453 0.900 rs12451122 chr17:28486376 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.62 0.38 2.61e-13 Coffee consumption (cups per day); LUSC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg21724239 chr8:58056113 NA 0.59 7.19 0.37 4.19e-12 Developmental language disorder (linguistic errors); LUSC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg20291162 chr17:40259547 DHX58 0.57 7.59 0.38 3.26e-13 Fibrinogen levels; LUSC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg00012203 chr2:219082015 ARPC2 -0.71 -11.57 -0.53 2.95e-26 Colorectal cancer; LUSC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs8192482 1 rs8192482 chr15:78886198 C/T cg06917634 chr15:78832804 PSMA4 -0.43 -5.94 -0.31 7.33e-9 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs13256369 0.802 rs2280560 chr8:8560602 C/T cg17143192 chr8:8559678 CLDN23 0.65 9.0 0.44 1.8e-17 Obesity-related traits; LUSC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg25427524 chr10:38739819 LOC399744 -0.66 -11.92 -0.55 1.53e-27 Extrinsic epigenetic age acceleration; LUSC cis rs6674176 0.542 rs803679 chr1:44349405 G/A cg12908607 chr1:44402522 ARTN -0.4 -5.83 -0.3 1.29e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2692947 0.832 rs2438972 chr2:96690873 T/C cg23100626 chr2:96804247 ASTL 0.25 6.4 0.33 5.18e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9807989 0.839 rs3755276 chr2:102978459 C/T cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs931127 0.719 rs2170082 chr11:65454795 A/G cg05805236 chr11:65401703 PCNXL3 -0.41 -7.09 -0.36 8.22e-12 Systemic lupus erythematosus; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg27560182 chr1:26511621 CNKSR1 -0.39 -6.35 -0.33 7.18e-10 N-glycan levels; LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg12432903 chr7:1882776 MAD1L1 -0.36 -5.75 -0.3 1.97e-8 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg24829409 chr8:58192753 C8orf71 -0.47 -5.68 -0.3 2.89e-8 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg05368731 chr17:41323189 NBR1 0.93 15.77 0.65 2.76e-42 Menopause (age at onset); LUSC trans rs9929218 0.954 rs17715762 chr16:68828250 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -10.8 -0.51 1.56e-23 Colorectal cancer; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.03 0.36 1.14e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs977987 0.778 rs4888400 chr16:75425596 G/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.96 -0.36 1.81e-11 Dupuytren's disease; LUSC trans rs2235573 0.527 rs139885 chr22:38371039 C/T cg19894588 chr14:64061835 NA 0.55 7.77 0.39 9.64e-14 Glioblastoma;Glioma; LUSC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC trans rs877282 0.891 rs11599917 chr10:762288 G/A cg13042288 chr15:90349979 ANPEP -0.44 -6.26 -0.32 1.21e-9 Uric acid levels; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.24 0.52 4.35e-25 Menopause (age at onset); LUSC cis rs753955 0.567 rs11617286 chr13:24409348 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.36 -5.79 -0.3 1.64e-8 Lung cancer; LUSC cis rs6121246 0.821 rs6119718 chr20:30331074 A/G cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC trans rs12210905 0.920 rs72839451 chr6:27265437 G/C cg11837749 chr1:55047332 ACOT11 0.66 6.3 0.33 9.13e-10 Hip circumference adjusted for BMI; LUSC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg14668632 chr7:2872130 GNA12 -0.42 -6.25 -0.32 1.27e-9 Height; LUSC cis rs7091068 0.671 rs1096025 chr10:95404701 T/C cg20715218 chr10:95462985 C10orf4 -0.6 -6.95 -0.36 1.94e-11 Urinary tract infection frequency; LUSC cis rs80130819 0.515 rs1476608 chr12:48493731 C/T cg24011408 chr12:48396354 COL2A1 0.44 5.96 0.31 6.48e-9 Prostate cancer; LUSC cis rs6977660 1.000 rs10249989 chr7:19822296 A/G cg07541023 chr7:19748670 TWISTNB 0.51 5.73 0.3 2.3e-8 Thyroid stimulating hormone; LUSC cis rs2688419 0.527 rs1355740 chr3:23070957 C/T cg00327796 chr3:23032191 NA 0.42 7.4 0.38 1.11e-12 Type 2 diabetes; LUSC cis rs523522 0.962 rs651627 chr12:121009198 C/T cg27279351 chr12:120934652 DYNLL1 0.64 8.78 0.43 8.94e-17 High light scatter reticulocyte count; LUSC cis rs8051149 0.688 rs12444670 chr16:87870312 C/T cg01412419 chr16:87856264 NA 0.48 7.59 0.38 3.25e-13 Blood metabolite levels; LUSC cis rs9583531 1.000 rs9583531 chr13:111385161 T/G cg24331049 chr13:111365604 ING1 -0.54 -5.92 -0.31 8.15e-9 Coronary artery disease; LUSC cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg21535247 chr6:8435926 SLC35B3 0.57 8.67 0.43 1.96e-16 Motion sickness; LUSC cis rs1215050 0.791 rs165244 chr4:98687889 C/T cg05340658 chr4:99064831 C4orf37 0.45 7.09 0.36 8.1e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg15145296 chr3:125709740 NA -0.55 -6.18 -0.32 1.88e-9 Blood pressure (smoking interaction); LUSC cis rs4073582 0.595 rs801739 chr11:65922589 A/G cg16950941 chr11:66035639 RAB1B 0.48 7.06 0.36 9.89e-12 Gout; LUSC cis rs4566357 0.595 rs6707159 chr2:227909339 T/A cg11843606 chr2:227700838 RHBDD1 -0.55 -8.57 -0.42 3.97e-16 Coronary artery disease; LUSC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg17724175 chr1:150552817 MCL1 0.38 6.82 0.35 4.17e-11 Tonsillectomy; LUSC trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg15934090 chr1:100435551 SLC35A3 0.47 8.16 0.41 6.96e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.697 rs28655325 chr4:120372999 A/G cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs965469 0.625 rs1043159 chr20:3232031 C/T cg25506879 chr20:3388711 C20orf194 -0.47 -6.47 -0.33 3.39e-10 IFN-related cytopenia; LUSC cis rs477692 0.905 rs544217 chr10:131420584 A/G cg11019008 chr10:131425282 MGMT 0.4 6.2 0.32 1.68e-9 Response to temozolomide; LUSC trans rs1456305 0.550 rs2392733 chr8:128100672 C/T cg22517681 chr1:24995876 SRRM1 0.64 7.23 0.37 3.22e-12 Prostate cancer; LUSC cis rs10883723 0.518 rs10786679 chr10:104315667 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.74 10.16 0.49 2.58e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs2073300 1.000 rs61080017 chr20:23457569 A/G cg09953122 chr20:23471693 CST8 -0.69 -6.86 -0.35 3.28e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7264396 0.832 rs224381 chr20:34097136 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.34 -0.33 7.6e-10 Total cholesterol levels; LUSC cis rs950169 0.881 rs34591918 chr15:84950833 C/T cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs7726839 0.540 rs72703080 chr5:595238 A/G cg16447950 chr5:562315 NA -0.57 -6.9 -0.35 2.68e-11 Obesity-related traits; LUSC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg06618935 chr21:46677482 NA -0.39 -7.81 -0.39 7.65e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3806843 0.933 rs2337987 chr5:140188383 T/G cg26395211 chr5:140044315 WDR55 -0.37 -5.65 -0.3 3.4e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1298062 0.605 rs12327751 chr19:50968890 G/T cg11430371 chr19:50961752 MYBPC2 0.29 5.83 0.3 1.34e-8 Age of smoking initiation; LUSC cis rs6542838 0.641 rs1581249 chr2:99500630 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -5.79 -0.3 1.64e-8 Fear of minor pain; LUSC trans rs853679 0.556 rs13200214 chr6:28017250 C/T cg06606381 chr12:133084897 FBRSL1 -0.95 -8.77 -0.43 9.39e-17 Depression; LUSC cis rs12950390 0.853 rs12450733 chr17:45855404 A/G cg03474202 chr17:45855739 NA -0.29 -6.69 -0.34 9.51e-11 IgG glycosylation; LUSC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg15448220 chr1:150897856 SETDB1 -0.41 -5.99 -0.31 5.37e-9 Melanoma; LUSC cis rs4803468 0.967 rs4803462 chr19:41908936 T/A cg09537434 chr19:41945824 ATP5SL -0.88 -15.49 -0.65 3.56e-41 Height; LUSC cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg23649088 chr2:200775458 C2orf69 -0.53 -6.82 -0.35 4.33e-11 Schizophrenia; LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs10979 0.557 rs9390120 chr6:143909411 A/G cg25407410 chr6:143891975 LOC285740 -0.65 -8.16 -0.41 7e-15 Hypospadias; LUSC trans rs3857536 0.785 rs2157964 chr6:66938419 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg25554036 chr4:6271136 WFS1 0.61 12.58 0.57 5.62e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12310956 0.510 rs11052882 chr12:33890017 T/C cg06521331 chr12:34319734 NA -0.36 -5.88 -0.31 1.02e-8 Morning vs. evening chronotype; LUSC cis rs17270561 0.609 rs9358883 chr6:25755515 A/G cg16482183 chr6:26056742 HIST1H1C 0.65 9.14 0.45 6.04e-18 Iron status biomarkers; LUSC cis rs7904368 0.754 rs11254231 chr10:16870246 A/G cg14835575 chr10:16859367 RSU1 0.72 9.22 0.45 3.31e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg23583168 chr7:148888333 NA -0.87 -16.13 -0.66 1.12e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1185460 0.967 rs1786684 chr11:118938435 G/A cg01677386 chr11:118938358 VPS11 -0.48 -6.82 -0.35 4.41e-11 Coronary artery disease; LUSC trans rs79976124 0.797 rs78317899 chr6:66652896 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 8.98 0.44 2.01e-17 Type 2 diabetes; LUSC cis rs7000551 0.751 rs2100291 chr8:22374551 C/T cg12081754 chr8:22256438 SLC39A14 0.45 6.88 0.35 2.88e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8022179 0.566 rs959083 chr14:103822687 A/G cg12935359 chr14:103987150 CKB -0.54 -7.22 -0.37 3.47e-12 Monocyte count; LUSC cis rs11153306 0.765 rs7740180 chr6:111944538 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.57 -0.34 1.91e-10 Tonsillectomy; LUSC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg10523679 chr1:76189770 ACADM 0.89 14.16 0.61 5.74e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7119167 0.901 rs10793060 chr11:73120653 A/G cg17517138 chr11:73019481 ARHGEF17 0.52 5.93 0.31 7.51e-9 Blood protein levels; LUSC cis rs9925964 0.748 rs11640961 chr16:30979818 C/T cg02466173 chr16:30829666 NA 0.38 7.15 0.36 5.39e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.64 -10.06 -0.48 5.8e-21 Blood protein levels; LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs62027291 0.898 rs2404232 chr15:77260575 G/T cg26408565 chr15:76604113 ETFA 0.56 6.48 0.33 3.26e-10 Plateletcrit; LUSC cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.82e-13 Motion sickness; LUSC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg23758822 chr17:41437982 NA 1.03 19.75 0.73 4.43e-58 Menopause (age at onset); LUSC cis rs13223928 0.538 rs10951042 chr7:3139417 T/C cg19214707 chr7:3157722 NA -0.45 -8.92 -0.44 3.09e-17 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC trans rs10946292 0.706 rs3012450 chr6:170438131 A/G cg17832364 chr10:94847294 NA 0.4 6.75 0.35 6.73e-11 Obesity-related traits; LUSC cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.34 0.33 7.51e-10 Rheumatoid arthritis; LUSC cis rs6845621 0.745 rs6449427 chr4:18865690 G/A cg12196642 chr4:18937545 NA -0.32 -5.91 -0.31 8.59e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs57920188 0.537 rs4440829 chr1:4080780 A/G cg20703997 chr1:4087676 NA -0.5 -6.79 -0.35 5.01e-11 Interleukin-17 levels; LUSC cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg00277334 chr10:82204260 NA -0.94 -20.09 -0.74 2.03e-59 Post bronchodilator FEV1; LUSC cis rs11112613 0.818 rs2374507 chr12:106009570 A/C cg03607813 chr12:105948248 NA 0.73 8.73 0.43 1.25e-16 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg26597838 chr10:835615 NA -0.48 -6.58 -0.34 1.8e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs4285028 0.747 rs7648343 chr3:121426195 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.89 -12.06 -0.55 4.85e-28 Multiple sclerosis; LUSC cis rs34734847 1.000 rs2948149 chr12:121162854 T/G cg27246729 chr12:121163418 ACADS 0.47 7.41 0.38 1.02e-12 Mean corpuscular volume; LUSC cis rs9467711 0.606 rs9379871 chr6:26375854 C/G cg14345882 chr6:26364793 BTN3A2 0.62 5.85 0.31 1.15e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs9303401 0.659 rs35082010 chr17:56936867 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.54 0.6 1.33e-33 Cognitive test performance; LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC cis rs7568458 0.709 rs56819945 chr2:85755139 C/T cg17127132 chr2:85788382 GGCX 0.42 6.07 0.32 3.48e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7608623 0.679 rs7561273 chr2:24247514 C/T cg08917208 chr2:24149416 ATAD2B 0.44 5.93 0.31 7.73e-9 Obesity-related traits; LUSC cis rs10904908 0.733 rs191693 chr10:17331115 G/A cg01003015 chr10:17271136 VIM 0.4 5.8 0.3 1.53e-8 Total cholesterol levels;Cholesterol, total; LUSC cis rs9300255 0.722 rs11830103 chr12:123823546 A/G cg00376283 chr12:123451042 ABCB9 -0.65 -7.67 -0.39 1.91e-13 Neutrophil percentage of white cells; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg13678112 chr14:89029552 ZC3H14 0.41 6.2 0.32 1.65e-9 Schizophrenia (age at onset); LUSC cis rs6815814 0.950 rs45588337 chr4:38807328 A/G cg02016764 chr4:38805732 TLR1 -0.54 -5.92 -0.31 7.93e-9 Breast cancer; LUSC cis rs4930103 0.904 rs4929984 chr11:2024683 A/C cg23202291 chr11:1979235 NA -0.36 -5.81 -0.3 1.44e-8 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.64 0.39 2.39e-13 Bipolar disorder; LUSC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs2387326 0.717 rs11016101 chr10:129945003 C/T cg16087940 chr10:129947807 NA -0.38 -5.81 -0.3 1.42e-8 Select biomarker traits; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg07167872 chr1:205819463 PM20D1 0.98 21.2 0.76 8.25e-64 Menarche (age at onset); LUSC cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg25554036 chr4:6271136 WFS1 0.6 12.05 0.55 5.21e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg15242686 chr22:24348715 GSTTP1 0.41 6.1 0.32 2.94e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17255340 0.577 rs12192297 chr6:84070966 T/C cg08257003 chr6:84140564 ME1 0.35 8.49 0.42 6.69e-16 Platelet-derived growth factor BB levels; LUSC cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg13256891 chr4:100009986 ADH5 -0.44 -6.11 -0.32 2.83e-9 Alcohol dependence; LUSC cis rs8072100 0.512 rs9674670 chr17:45386157 G/A cg25173405 chr17:45401733 C17orf57 -0.42 -6.76 -0.35 6.26e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs62408225 0.802 rs10806425 chr6:90926612 C/A cg06866423 chr6:90926672 BACH2 0.42 6.45 0.33 3.89e-10 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs877282 0.898 rs10904546 chr10:757222 A/G cg22713356 chr15:30763199 NA 1.03 13.61 0.6 7.56e-34 Uric acid levels; LUSC cis rs4819052 0.788 rs2236449 chr21:46702506 C/T cg06618935 chr21:46677482 NA -0.29 -5.71 -0.3 2.47e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs981844 0.921 rs2606336 chr4:154656792 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg26668828 chr6:292823 DUSP22 -0.53 -7.97 -0.4 2.51e-14 Menopause (age at onset); LUSC cis rs7202877 0.656 rs4888374 chr16:75322228 T/C cg03315344 chr16:75512273 CHST6 0.41 6.02 0.31 4.59e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs11122272 0.766 rs2808608 chr1:231543175 A/G cg06096015 chr1:231504339 EGLN1 0.54 9.31 0.45 1.7e-18 Hemoglobin concentration; LUSC cis rs4938330 0.723 rs7931398 chr11:116879676 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.46 -6.17 -0.32 1.96e-9 Blood protein levels; LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg01802117 chr1:53393560 SCP2 -0.43 -7.19 -0.37 4.19e-12 Monocyte count; LUSC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg14949292 chr17:78079608 GAA -0.31 -5.65 -0.3 3.39e-8 Yeast infection; LUSC cis rs6456156 0.773 rs6456159 chr6:167529272 T/A cg07741184 chr6:167504864 NA -0.37 -6.66 -0.34 1.12e-10 Primary biliary cholangitis; LUSC cis rs4595586 0.545 rs12812959 chr12:39371197 T/C cg26384229 chr12:38710491 ALG10B 0.49 6.95 0.36 1.93e-11 Morning vs. evening chronotype; LUSC cis rs7681440 0.904 rs6532193 chr4:90764188 G/A cg20003494 chr4:90757398 SNCA -0.33 -5.71 -0.3 2.5e-8 Dementia with Lewy bodies; LUSC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg09703963 chr11:616879 IRF7;MUPCDH -0.46 -7.29 -0.37 2.3e-12 Systemic lupus erythematosus; LUSC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg20307385 chr11:47447363 PSMC3 -0.44 -5.73 -0.3 2.23e-8 Subjective well-being; LUSC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.25 0.32 1.28e-9 Personality dimensions; LUSC cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 0.41 6.6 0.34 1.64e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7824557 0.736 rs35392635 chr8:11164349 G/C cg27411982 chr8:10470053 RP1L1 0.38 5.9 0.31 8.94e-9 Retinal vascular caliber; LUSC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.02 14.9 0.63 7.22e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs440932 1.000 rs378974 chr8:9026639 C/T cg15556689 chr8:8085844 FLJ10661 0.46 6.4 0.33 5.19e-10 High light scatter reticulocyte percentage of red cells; LUSC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg02269571 chr22:50332266 NA -0.55 -8.2 -0.41 5.16e-15 Schizophrenia; LUSC cis rs2204008 0.515 rs11495471 chr12:38027178 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.76 0.65 3.11e-42 Bladder cancer; LUSC cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg16586182 chr3:47516702 SCAP -0.47 -7.44 -0.38 8.45e-13 Colorectal cancer; LUSC trans rs11039571 0.588 rs10734564 chr11:48160429 A/G cg15704280 chr7:45808275 SEPT13 -0.65 -6.89 -0.35 2.86e-11 D-dimer levels; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg22638593 chr5:131593259 PDLIM4 0.36 5.79 0.3 1.61e-8 Blood metabolite levels; LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.57 0.67 2.06e-45 Platelet count; LUSC cis rs9527 0.615 rs36045108 chr10:104697929 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.48 0.46 5e-19 Arsenic metabolism; LUSC trans rs1728785 1.000 rs1170442 chr16:68574064 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.65 0.39 2.18e-13 Ulcerative colitis; LUSC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 8.84 0.44 5.48e-17 Schizophrenia; LUSC cis rs61931739 0.500 rs7298322 chr12:34445489 A/T cg06521331 chr12:34319734 NA -0.41 -6.74 -0.35 6.92e-11 Morning vs. evening chronotype; LUSC trans rs9976767 0.637 rs2277799 chr21:43824123 G/C cg19213045 chr13:40180622 NA 0.31 5.96 0.31 6.53e-9 Type 1 diabetes; LUSC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg21435336 chr19:17392852 ANKLE1 -0.43 -5.87 -0.31 1.07e-8 Systemic lupus erythematosus; LUSC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg15017067 chr4:17643749 FAM184B 0.36 5.96 0.31 6.28e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg27446573 chr6:127587934 RNF146 0.92 15.23 0.64 3.94e-40 Breast cancer; LUSC cis rs6424115 0.830 rs1130321 chr1:24200524 C/T cg10978503 chr1:24200527 CNR2 0.54 13.3 0.59 1.09e-32 Immature fraction of reticulocytes; LUSC cis rs12464483 0.524 rs2602772 chr2:30885263 C/A cg17749961 chr2:30669863 LCLAT1 0.63 7.8 0.39 7.96e-14 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs9818758 0.607 rs3923475 chr3:49055788 G/T cg00383909 chr3:49044727 WDR6 1.36 11.72 0.54 8.29e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC cis rs11098499 0.908 rs12504149 chr4:120318577 G/A cg24375607 chr4:120327624 NA 0.77 11.3 0.53 2.73e-25 Corneal astigmatism; LUSC cis rs7100689 0.784 rs7082705 chr10:82170856 C/T cg00277334 chr10:82204260 NA 0.52 7.29 0.37 2.32e-12 Post bronchodilator FEV1; LUSC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08109568 chr15:31115862 NA 0.48 6.97 0.36 1.71e-11 Huntington's disease progression; LUSC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg08493051 chr2:3487164 NA 0.53 8.3 0.41 2.52e-15 Neurofibrillary tangles; LUSC cis rs61931739 0.517 rs1586409 chr12:34046614 C/A cg06521331 chr12:34319734 NA -0.51 -8.37 -0.42 1.55e-15 Morning vs. evening chronotype; LUSC trans rs7939886 0.920 rs78769647 chr11:55965527 C/T cg15704280 chr7:45808275 SEPT13 0.89 6.81 0.35 4.56e-11 Myopia (pathological); LUSC cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg16339924 chr4:17578868 LAP3 0.66 10.14 0.48 3.16e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7312933 0.558 rs4768402 chr12:42755576 A/G cg01256987 chr12:42539512 GXYLT1 0.35 6.37 0.33 6.16e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4713675 0.584 rs3818527 chr6:33661035 A/G cg14003231 chr6:33640908 ITPR3 -0.31 -5.98 -0.31 5.86e-9 Plateletcrit; LUSC cis rs3772130 0.961 rs13072618 chr3:121391833 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.68 10.06 0.48 5.63e-21 Cognitive performance; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.9 0.4 4.21e-14 Prudent dietary pattern; LUSC cis rs7119 0.717 rs12917314 chr15:77818285 T/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.61 -0.34 1.53e-10 Type 2 diabetes; LUSC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg25019033 chr10:957182 NA -0.51 -6.41 -0.33 5.04e-10 Eosinophil percentage of granulocytes; LUSC cis rs7712401 0.601 rs154501 chr5:122211594 T/C cg19077854 chr5:122220652 SNX24 0.41 9.2 0.45 3.93e-18 Mean platelet volume; LUSC cis rs11031096 0.868 rs2920144 chr11:4060283 A/G cg18678763 chr11:4115507 RRM1 0.4 5.89 0.31 9.38e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23705032 chr10:12237872 NUDT5;CDC123 -0.4 -6.0 -0.31 5.2e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7789940 0.904 rs6948661 chr7:75961647 T/C cg10167463 chr7:75959203 YWHAG -0.66 -10.07 -0.48 5.33e-21 Multiple sclerosis; LUSC cis rs7712401 0.601 rs246308 chr5:122270090 G/T cg19077854 chr5:122220652 SNX24 0.41 8.94 0.44 2.64e-17 Mean platelet volume; LUSC cis rs7103411 0.637 rs7116850 chr11:27645530 C/T cg18117895 chr11:27722066 BDNF -0.44 -5.87 -0.31 1.04e-8 Menarche (age at onset);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs11264799 0.765 rs12136747 chr1:157636930 C/G cg18268488 chr1:157545234 FCRL4 -0.33 -5.91 -0.31 8.64e-9 IgA nephropathy; LUSC cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.91e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9300255 0.602 rs2510885 chr12:123614813 G/C cg05973401 chr12:123451056 ABCB9 0.55 6.93 0.35 2.2e-11 Neutrophil percentage of white cells; LUSC cis rs1577917 0.958 rs12198876 chr6:86525476 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.47e-11 Response to antipsychotic treatment; LUSC trans rs7824557 0.545 rs34482136 chr8:11227885 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.27 -0.41 3.26e-15 Retinal vascular caliber; LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.74 0.65 3.76e-42 Platelet count; LUSC cis rs12210905 0.688 rs114188783 chr6:27449604 T/C cg08851530 chr6:28072375 NA 0.97 6.01 0.31 4.99e-9 Hip circumference adjusted for BMI; LUSC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg05535760 chr7:792225 HEATR2 0.81 9.7 0.47 9.49e-20 Cerebrospinal P-tau181p levels; LUSC cis rs9814567 1.000 rs6793487 chr3:134299426 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 13.55 0.6 1.2e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg24829409 chr8:58192753 C8orf71 -0.62 -7.9 -0.4 3.96e-14 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg00149659 chr3:10157352 C3orf10 1.0 14.77 0.63 2.33e-38 Alzheimer's disease; LUSC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg20135002 chr11:47629003 NA -0.51 -7.99 -0.4 2.16e-14 Subjective well-being; LUSC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg08048268 chr3:133502702 NA -0.36 -6.46 -0.33 3.65e-10 Iron status biomarkers; LUSC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg09034736 chr1:150693464 HORMAD1 0.45 6.44 0.33 4.28e-10 Melanoma; LUSC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg11344533 chr11:111475393 SIK2 -0.49 -6.89 -0.35 2.86e-11 Primary sclerosing cholangitis; LUSC cis rs113835537 0.529 rs79798028 chr11:66199362 T/G cg24851651 chr11:66362959 CCS 0.54 8.29 0.41 2.71e-15 Airway imaging phenotypes; LUSC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg23791538 chr6:167370224 RNASET2 -0.39 -6.07 -0.32 3.47e-9 Crohn's disease; LUSC cis rs73200209 0.703 rs17498942 chr12:116686117 C/G cg01776926 chr12:116560359 MED13L -0.49 -5.98 -0.31 5.81e-9 Total body bone mineral density; LUSC cis rs4144743 0.938 rs7225134 chr17:45326932 C/T cg18085866 chr17:45331354 ITGB3 -0.75 -7.79 -0.39 8.26e-14 Body mass index; LUSC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.48 0.46 4.78e-19 Prudent dietary pattern; LUSC cis rs72781680 1.000 rs17711825 chr2:24124578 A/G cg08917208 chr2:24149416 ATAD2B 0.87 9.93 0.48 1.56e-20 Lymphocyte counts; LUSC trans rs208520 0.690 rs851468 chr6:66825875 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.48 -0.69 4.87e-49 Exhaled nitric oxide output; LUSC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg01973587 chr1:228161476 NA 0.34 5.97 0.31 6.03e-9 Diastolic blood pressure; LUSC cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg06060754 chr5:176797920 RGS14 -0.57 -9.05 -0.44 1.18e-17 Hemoglobin concentration;Hematocrit; LUSC cis rs1348850 0.645 rs10181259 chr2:178428256 C/A cg23306229 chr2:178417860 TTC30B 0.53 6.1 0.32 2.87e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg03264133 chr6:25882463 NA -0.46 -7.83 -0.39 6.55e-14 Intelligence (multi-trait analysis); LUSC cis rs6840360 0.571 rs4696099 chr4:152501951 C/G cg22705602 chr4:152727874 NA -0.3 -6.02 -0.31 4.55e-9 Intelligence (multi-trait analysis); LUSC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg08859206 chr1:53392774 SCP2 -0.41 -6.62 -0.34 1.42e-10 Monocyte count; LUSC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.87 0.66 1.16e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3862030 0.720 rs7342070 chr10:104223628 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.59 -9.18 -0.45 4.47e-18 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg22963979 chr7:1858916 MAD1L1 0.56 8.41 0.42 1.18e-15 Bipolar disorder and schizophrenia; LUSC cis rs7264396 0.676 rs6058383 chr20:34556005 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg20891283 chr12:69753455 YEATS4 0.81 14.62 0.62 9.49e-38 Blood protein levels; LUSC cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg23649088 chr2:200775458 C2orf69 -0.47 -6.31 -0.33 8.98e-10 Schizophrenia; LUSC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg11663144 chr21:46675770 NA -0.38 -6.13 -0.32 2.53e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg24399712 chr22:39784796 NA -0.41 -5.94 -0.31 6.97e-9 IgG glycosylation; LUSC cis rs6952809 0.532 rs7803015 chr7:2432143 G/A cg23289794 chr7:2394357 EIF3B -0.7 -9.6 -0.46 2.02e-19 Multiple sclerosis; LUSC cis rs17253792 0.822 rs112374071 chr14:56061919 C/T cg01858014 chr14:56050164 KTN1 -0.92 -7.5 -0.38 5.82e-13 Putamen volume; LUSC cis rs9796 0.558 rs7166905 chr15:41514876 G/C cg18705301 chr15:41695430 NDUFAF1 -0.5 -8.88 -0.44 4.17e-17 Menopause (age at onset); LUSC trans rs7937682 1.000 rs10502147 chr11:111569931 G/A cg18187862 chr3:45730750 SACM1L -0.55 -6.78 -0.35 5.52e-11 Primary sclerosing cholangitis; LUSC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg03676636 chr4:99064102 C4orf37 0.36 7.7 0.39 1.5700000000000001e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2580764 0.566 rs2972072 chr2:55295370 G/T cg09592903 chr2:55203963 RTN4 0.46 9.25 0.45 2.69e-18 Mean platelet volume; LUSC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg11494091 chr17:61959527 GH2 0.62 13.31 0.59 1.01e-32 Prudent dietary pattern; LUSC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg03806693 chr22:41940476 POLR3H -1.01 -14.23 -0.61 3.01e-36 Vitiligo; LUSC cis rs950881 0.932 rs72823619 chr2:102924615 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.34 0.33 7.25e-10 Allergy; LUSC cis rs9818941 0.824 rs4511848 chr3:157732021 A/C cg08654915 chr3:157813417 NA -0.31 -7.2 -0.37 4.1e-12 Height; LUSC cis rs9467773 0.967 rs9461267 chr6:26525455 T/G cg09904177 chr6:26538194 HMGN4 0.75 14.34 0.62 1.18e-36 Intelligence (multi-trait analysis); LUSC trans rs1908814 0.516 rs35391955 chr8:11796728 A/C cg27411982 chr8:10470053 RP1L1 0.41 6.32 0.33 8.43e-10 Neuroticism; LUSC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg10018233 chr7:150070692 REPIN1 0.46 9.44 0.46 6.86e-19 Blood protein levels;Circulating chemerin levels; LUSC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.11e-11 Crohn's disease; LUSC trans rs7824557 0.767 rs6985146 chr8:11170721 A/C cg15556689 chr8:8085844 FLJ10661 0.52 7.52 0.38 5.05e-13 Retinal vascular caliber; LUSC cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg16586182 chr3:47516702 SCAP -0.48 -7.64 -0.39 2.34e-13 Colorectal cancer; LUSC cis rs870825 0.616 rs61539306 chr4:185650276 C/T cg04058563 chr4:185651563 MLF1IP 0.81 12.21 0.56 1.35e-28 Blood protein levels; LUSC cis rs77633900 0.772 rs284903 chr15:76744813 G/A cg21673338 chr15:77095150 SCAPER -0.7 -6.03 -0.31 4.41e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs9457247 1.000 rs422094 chr6:167397033 C/G cg25258033 chr6:167368657 RNASET2 0.47 7.83 0.39 6.66e-14 Crohn's disease; LUSC trans rs995000 0.931 rs626787 chr1:62901243 C/G cg15440331 chr11:43380331 TTC17 0.45 6.25 0.32 1.22e-9 Triglyceride levels; LUSC cis rs11785400 0.793 rs7000765 chr8:143722457 G/A cg24634471 chr8:143751801 JRK 0.5 7.13 0.36 6.36e-12 Schizophrenia; LUSC cis rs9467773 1.000 rs10484442 chr6:26555879 A/G cg11502198 chr6:26597334 ABT1 0.62 9.65 0.47 1.34e-19 Intelligence (multi-trait analysis); LUSC cis rs240764 0.631 rs9386250 chr6:101204126 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.32e-9 Neuroticism; LUSC cis rs2730245 0.661 rs842696 chr7:158662698 T/C cg11984989 chr7:158649758 WDR60 1.07 21.81 0.77 3.37e-66 Height; LUSC cis rs7210086 0.948 rs17780256 chr17:70642923 A/C cg04206342 chr17:70636940 NA -0.37 -5.76 -0.3 1.86e-8 Ulcerative colitis; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 7.84e-17 Prudent dietary pattern; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18679299 chr14:24664866 TM9SF1 0.44 6.01 0.31 4.88e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9303401 0.659 rs12944971 chr17:56988801 A/T cg25039879 chr17:56429692 SUPT4H1 0.7 9.16 0.45 5.34e-18 Cognitive test performance; LUSC cis rs603424 0.551 rs525190 chr10:102087038 C/T cg10365880 chr10:102089681 PKD2L1 -0.54 -6.88 -0.35 2.88e-11 Phospholipid levels (plasma);Palmitic acid (16:0) levels;Palmitoleic acid (16:1n-7) levels;Mean platelet volume;Serum metabolite levels;Blood metabolite levels;Vaccenic acid (18:1n-7) levels;Metabolic traits;Coronary artery disease;Blood metabolite ratios;Glycerophospholipid levels; LUSC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg03806693 chr22:41940476 POLR3H -0.89 -12.81 -0.57 8.03e-31 Vitiligo; LUSC cis rs17095355 1.000 rs61614979 chr10:111743994 A/G cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.56 -0.38 3.97e-13 Biliary atresia; LUSC cis rs10744422 0.528 rs6489245 chr12:123360151 G/A cg25930673 chr12:123319894 HIP1R -0.63 -6.25 -0.32 1.28e-9 Schizophrenia; LUSC trans rs11098499 0.954 rs34858317 chr4:120387110 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.2 0.32 1.7e-9 Corneal astigmatism; LUSC trans rs7615952 0.932 rs11922218 chr3:125631289 C/T cg07211511 chr3:129823064 LOC729375 -1.18 -17.99 -0.7 4.68e-51 Blood pressure (smoking interaction); LUSC cis rs2625529 0.824 rs35112434 chr15:72448326 G/T cg16672083 chr15:72433130 SENP8 -0.51 -7.42 -0.38 1.01e-12 Red blood cell count; LUSC cis rs4631830 0.869 rs7896437 chr10:51529593 A/C cg16070123 chr10:51489643 NA -0.52 -8.08 -0.4 1.22e-14 Prostate-specific antigen levels; LUSC cis rs7605827 0.930 rs2241237 chr2:15656157 A/T cg19274914 chr2:15703543 NA 0.46 9.06 0.44 1.16e-17 Educational attainment (years of education); LUSC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg16240275 chr20:61666158 NCRNA00029 0.42 9.26 0.45 2.55e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs6545883 0.929 rs2421203 chr2:61669248 C/A cg15711740 chr2:61764176 XPO1 -0.46 -7.2 -0.37 3.94e-12 Tuberculosis; LUSC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg10664184 chr19:17420304 DDA1 0.47 6.13 0.32 2.53e-9 Systemic lupus erythematosus; LUSC cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg16230307 chr14:35515116 FAM177A1 0.82 10.26 0.49 1.23e-21 Psoriasis; LUSC cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg27129171 chr3:47204927 SETD2 -0.71 -12.31 -0.56 5.48e-29 Colorectal cancer; LUSC cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.93e-21 Bladder cancer; LUSC trans rs6502050 0.871 rs7226049 chr17:80071049 A/G cg07393940 chr7:158741817 NA -0.37 -6.58 -0.34 1.85e-10 Life satisfaction; LUSC cis rs34779708 0.931 rs4007289 chr10:35269790 G/A cg03585969 chr10:35415529 CREM 0.62 9.07 0.44 1.04e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs7937682 0.883 rs529529 chr11:111461128 C/T cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC trans rs1147199 0.585 rs726433 chr9:87247336 C/T cg18287975 chr5:88178977 MEF2C -0.72 -6.29 -0.33 9.69e-10 Body mass index; LUSC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.88 -0.35 3.05e-11 Lung cancer; LUSC trans rs11039798 1.000 rs7131020 chr11:48642132 A/G cg03929089 chr4:120376271 NA 0.64 6.03 0.31 4.42e-9 Axial length; LUSC cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.51 7.59e-24 Schizophrenia; LUSC cis rs2067615 0.560 rs2044304 chr12:107184363 T/G cg15890332 chr12:107067104 RFX4 0.34 6.18 0.32 1.91e-9 Heart rate; LUSC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.39 0.59 5.09e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg08109568 chr15:31115862 NA -0.74 -11.04 -0.52 2.25e-24 Huntington's disease progression; LUSC cis rs2439831 0.850 rs12440573 chr15:44108997 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.92 9.09 0.45 8.9e-18 Lung cancer in ever smokers; LUSC cis rs5758511 0.773 rs62240997 chr22:42354567 T/G cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.98 -0.31 5.88e-9 Birth weight; LUSC cis rs2387326 0.672 rs10829344 chr10:129944569 A/C cg16087940 chr10:129947807 NA -0.39 -6.0 -0.31 5.27e-9 Select biomarker traits; LUSC cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg20908204 chr19:46285434 DMPK -0.47 -8.82 -0.43 6.38e-17 Coronary artery disease; LUSC cis rs6570726 1.000 rs6570699 chr6:145920732 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -5.78 -0.3 1.72e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7949030 1.000 rs10897289 chr11:62400016 T/C cg22862634 chr11:62369728 EML3;MTA2 0.5 8.1 0.41 1.04e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7829975 0.774 rs11775523 chr8:8679176 A/G cg21775007 chr8:11205619 TDH 0.43 6.13 0.32 2.46e-9 Mood instability; LUSC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -7.02 -0.36 1.23e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs5771242 0.518 rs5771258 chr22:50675648 C/A cg08875078 chr22:50639485 SELO 0.46 5.94 0.31 7.04e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); LUSC cis rs7089973 0.628 rs11196953 chr10:116607707 A/G cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7107174 0.901 rs2512525 chr11:77923019 T/C cg02023728 chr11:77925099 USP35 0.52 6.93 0.35 2.15e-11 Testicular germ cell tumor; LUSC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg12463550 chr7:65579703 CRCP 0.63 5.69 0.3 2.82e-8 Diabetic kidney disease; LUSC trans rs61931739 0.583 rs1873010 chr12:33756375 T/C cg26384229 chr12:38710491 ALG10B 0.43 6.24 0.32 1.31e-9 Morning vs. evening chronotype; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04210544 chr13:111806530 ARHGEF7 0.39 6.71 0.34 8.36e-11 Triglycerides; LUSC cis rs9788682 1.000 rs12441426 chr15:78812329 T/C cg24631222 chr15:78858424 CHRNA5 0.83 11.54 0.53 3.73e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9612 1.000 rs347519 chr19:44273516 T/C cg08581076 chr19:44259116 C19orf61 0.47 5.78 0.3 1.75e-8 Exhaled nitric oxide output; LUSC cis rs1801251 1.000 rs7587309 chr2:233705702 G/T cg08000102 chr2:233561755 GIGYF2 -0.71 -11.76 -0.54 5.82e-27 Coronary artery disease; LUSC cis rs12618769 0.520 rs4851135 chr2:99050705 T/A cg10123293 chr2:99228465 UNC50 0.45 7.64 0.39 2.31e-13 Bipolar disorder; LUSC cis rs1020064 0.895 rs2250659 chr2:105889684 A/G cg02079111 chr2:105885981 TGFBRAP1 0.65 8.65 0.43 2.25e-16 AIDS; LUSC cis rs17407555 0.738 rs56143194 chr4:10067535 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -6.37 -0.33 6.3e-10 Schizophrenia (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13110711 chr17:27894392 ABHD15;TP53I13 -0.42 -6.21 -0.32 1.6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.01 0.77 5.62e-67 Prudent dietary pattern; LUSC cis rs7666738 0.546 rs11097591 chr4:98910173 G/A cg03676636 chr4:99064102 C4orf37 0.3 6.12 0.32 2.57e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4654899 1.000 rs7543126 chr1:21406088 T/G cg01072550 chr1:21505969 NA -0.51 -7.88 -0.4 4.75e-14 Superior frontal gyrus grey matter volume; LUSC cis rs478304 0.654 rs7934036 chr11:65451020 G/T cg05805236 chr11:65401703 PCNXL3 -0.63 -10.35 -0.49 5.99e-22 Acne (severe); LUSC cis rs11031096 0.711 rs4910890 chr11:4153407 C/T cg08557956 chr11:4115526 RRM1 -0.42 -5.72 -0.3 2.34e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg03213289 chr20:61660250 NA 0.66 13.24 0.59 1.82e-32 Prostate cancer (SNP x SNP interaction); LUSC cis rs7819412 0.595 rs4841500 chr8:10988275 A/G cg21775007 chr8:11205619 TDH -0.52 -7.37 -0.37 1.34e-12 Triglycerides; LUSC cis rs752010 0.714 rs7513753 chr1:42079232 A/G cg06885757 chr1:42089581 HIVEP3 0.48 10.38 0.49 4.7e-22 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -6.03 -0.31 4.24e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6460942 0.591 rs62451464 chr7:12363059 C/A cg06484146 chr7:12443880 VWDE -0.58 -6.28 -0.33 1.02e-9 Coronary artery disease; LUSC cis rs10883723 0.962 rs1056739 chr10:104236542 T/C cg22532475 chr10:104410764 TRIM8 -0.34 -7.4 -0.38 1.1e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg06627557 chr7:32535165 LSM5;AVL9 1.09 22.77 0.78 5.98e-70 Cognitive ability; LUSC cis rs950027 0.620 rs1617634 chr15:45615578 A/G cg21132104 chr15:45694354 SPATA5L1 0.4 5.68 0.3 2.87e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs950169 0.887 rs71395453 chr15:85113490 G/C cg11189052 chr15:85197271 WDR73 0.47 5.81 0.3 1.44e-8 Schizophrenia; LUSC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -11.85 -0.54 2.69e-27 Hemoglobin concentration; LUSC cis rs4595586 0.545 rs12828790 chr12:39401043 G/A cg26384229 chr12:38710491 ALG10B 0.5 7.09 0.36 7.95e-12 Morning vs. evening chronotype; LUSC cis rs1355223 0.533 rs1597960 chr11:34726969 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.13 -0.32 2.55e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg10664184 chr19:17420304 DDA1 0.47 5.81 0.3 1.48e-8 Systemic lupus erythematosus; LUSC cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg23992470 chr4:843637 GAK 0.6 6.41 0.33 5.02e-10 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg15145296 chr3:125709740 NA -0.59 -6.49 -0.33 3.19e-10 Blood pressure (smoking interaction); LUSC cis rs11250097 0.535 rs11250086 chr8:10769783 A/G cg27411982 chr8:10470053 RP1L1 -0.46 -6.76 -0.35 5.99e-11 Neuroticism; LUSC cis rs6545883 0.868 rs7594191 chr2:61840018 A/G cg15711740 chr2:61764176 XPO1 0.45 6.93 0.35 2.24e-11 Tuberculosis; LUSC cis rs11148252 0.624 rs6561682 chr13:53266297 A/G cg00495681 chr13:53174319 NA -0.46 -6.72 -0.35 7.95e-11 Lewy body disease; LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg06145435 chr7:1022769 CYP2W1 0.28 5.68 0.3 2.98e-8 Longevity;Endometriosis; LUSC cis rs9807841 0.592 rs3810154 chr19:10764914 G/A cg09936142 chr19:10668400 KRI1 -0.41 -6.68 -0.34 9.95e-11 Inflammatory skin disease; LUSC cis rs644799 0.526 rs693792 chr11:95622200 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.58 8.75 0.43 1.07e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1018836 0.923 rs34126139 chr8:91572045 T/G cg16814680 chr8:91681699 NA -0.75 -12.55 -0.57 7.6e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7592578 0.639 rs13417431 chr2:191293055 A/G cg11845111 chr2:191398756 TMEM194B -0.82 -10.91 -0.51 6.77e-24 Diastolic blood pressure; LUSC trans rs8072100 0.967 rs8075411 chr17:45676760 C/T cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.18e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7647973 0.769 rs4974081 chr3:49070499 A/G cg07636037 chr3:49044803 WDR6 -0.85 -11.68 -0.54 1.21e-26 Menarche (age at onset); LUSC cis rs72634258 0.786 rs9434992 chr1:8179392 G/T cg00042356 chr1:8021962 PARK7 0.54 6.59 0.34 1.72e-10 Inflammatory bowel disease; LUSC cis rs1256061 0.603 rs10148269 chr14:64736924 A/G cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.18e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg22868518 chr11:507468 RNH1 -0.61 -5.97 -0.31 6.11e-9 Body mass index; LUSC cis rs734999 0.869 rs1555791 chr1:2498862 G/C cg18854424 chr1:2615690 NA 0.47 9.7 0.47 9.06e-20 Ulcerative colitis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22218058 chr3:32021831 OSBPL10;ZNF860 -0.45 -6.68 -0.34 1e-10 Hepatitis; LUSC cis rs208520 0.661 rs207099 chr6:66796373 A/C cg07460842 chr6:66804631 NA -1.13 -17.52 -0.69 3.44e-49 Exhaled nitric oxide output; LUSC cis rs56804039 1.000 rs11777086 chr8:8384479 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -6.67 -0.34 1.04e-10 Cervical cancer; LUSC cis rs7607369 0.719 rs7567622 chr2:219624549 A/T cg02176678 chr2:219576539 TTLL4 -0.58 -10.35 -0.49 5.77e-22 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7584330 0.554 rs6706729 chr2:238398580 T/C cg14458575 chr2:238380390 NA 0.78 8.81 0.43 7.09e-17 Prostate cancer; LUSC cis rs9399135 0.967 rs4895434 chr6:135293365 G/A cg24558204 chr6:135376177 HBS1L 0.57 8.58 0.43 3.55e-16 Red blood cell count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12842013 chr14:23755227 HOMEZ -0.44 -6.67 -0.34 1.04e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg19812747 chr11:111475976 SIK2 0.46 5.98 0.31 5.86e-9 Primary sclerosing cholangitis; LUSC cis rs394563 0.591 rs237035 chr6:149710848 C/T cg03678062 chr6:149772716 ZC3H12D -0.31 -6.38 -0.33 5.97e-10 Dupuytren's disease; LUSC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg14668632 chr7:2872130 GNA12 -0.45 -6.31 -0.33 9.07e-10 Height; LUSC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg16049864 chr8:95962084 TP53INP1 -0.64 -12.0 -0.55 7.62e-28 Type 2 diabetes; LUSC cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg05985134 chr18:33552581 C18orf21 -0.52 -7.24 -0.37 3.06e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs6500395 1.000 rs11640463 chr16:48644434 A/T cg04672837 chr16:48644449 N4BP1 0.48 7.06 0.36 9.74e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg12311346 chr5:56204834 C5orf35 0.74 12.28 0.56 7.38e-29 Initial pursuit acceleration; LUSC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg06219351 chr7:158114137 PTPRN2 -0.53 -9.47 -0.46 5.14e-19 Calcium levels; LUSC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg12463550 chr7:65579703 CRCP 0.41 5.93 0.31 7.36e-9 Aortic root size; LUSC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg02569458 chr12:86230093 RASSF9 0.47 7.52 0.38 5.13e-13 Major depressive disorder; LUSC cis rs9457247 1.000 rs393727 chr6:167398632 T/A cg25258033 chr6:167368657 RNASET2 0.47 7.84 0.39 6.15e-14 Crohn's disease; LUSC cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.1 0.72 1.79e-55 Chronic sinus infection; LUSC trans rs12705849 0.797 rs13230450 chr7:112754904 A/T cg04564980 chr10:134974877 KNDC1 -0.35 -6.26 -0.32 1.18e-9 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells;Eosinophil counts; LUSC trans rs11098499 0.954 rs11098524 chr4:120390032 A/G cg25214090 chr10:38739885 LOC399744 0.48 6.63 0.34 1.39e-10 Corneal astigmatism; LUSC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg24154853 chr7:158122151 PTPRN2 0.45 8.87 0.44 4.48e-17 Calcium levels; LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.966 rs2482923 chr20:25308981 T/C cg08601574 chr20:25228251 PYGB -0.42 -6.5 -0.33 2.98e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.44 6.45 0.33 4.03e-10 Breast cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10577467 chr4:39183765 WDR19 0.39 5.97 0.31 6.18e-9 Triglycerides; LUSC cis rs12950390 1.000 rs12950390 chr17:45830948 A/G cg06532163 chr17:45867833 NA 0.34 5.91 0.31 8.21e-9 IgG glycosylation; LUSC cis rs10465746 0.905 rs12738214 chr1:84359050 C/A cg10977910 chr1:84465055 TTLL7 0.42 5.99 0.31 5.39e-9 Obesity-related traits; LUSC cis rs829883 0.573 rs73136486 chr12:98913727 T/A cg25150519 chr12:98850993 NA -0.63 -8.6 -0.43 3.08e-16 Colorectal adenoma (advanced); LUSC cis rs868036 0.609 rs3784707 chr15:68043878 A/C cg27219399 chr15:67835830 MAP2K5 0.37 5.76 0.3 1.9e-8 Restless legs syndrome; LUSC cis rs7580658 0.895 rs62157549 chr2:128066007 A/G cg09760422 chr2:128146352 NA -0.29 -6.19 -0.32 1.76e-9 Protein C levels; LUSC cis rs7528419 0.895 rs583104 chr1:109821307 G/T cg00908766 chr1:109817496 CELSR2 0.64 10.05 0.48 6.39e-21 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; LUSC cis rs7098414 0.511 rs7899545 chr10:82150635 G/C cg00277334 chr10:82204260 NA -0.55 -8.94 -0.44 2.71e-17 Post bronchodilator FEV1; LUSC trans rs853679 0.517 rs9393885 chr6:28050009 A/T cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg25174290 chr11:3078921 CARS 0.58 9.4 0.46 9.23e-19 Longevity; LUSC cis rs7582180 0.845 rs7607676 chr2:100896966 G/A cg08017756 chr2:100939284 LONRF2 -0.37 -6.18 -0.32 1.83e-9 Intelligence (multi-trait analysis); LUSC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg22862634 chr11:62369728 EML3;MTA2 0.5 8.41 0.42 1.24e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9399135 0.967 rs9376085 chr6:135371224 T/C cg24558204 chr6:135376177 HBS1L 0.57 8.77 0.43 9.11e-17 Red blood cell count; LUSC cis rs4363385 0.818 rs946096 chr1:153006529 T/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs7267979 1.000 rs6515651 chr20:25414539 T/G cg08601574 chr20:25228251 PYGB -0.44 -6.79 -0.35 5.29e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs78456975 1.000 rs55761535 chr2:1561450 A/G cg01028140 chr2:1542097 TPO -0.62 -8.38 -0.42 1.47e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC trans rs10492201 0.529 rs4913269 chr12:68407845 C/G cg21566642 chr2:233284661 NA -0.38 -6.04 -0.31 4.05e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.53 -7.24 -0.37 3.11e-12 Mean platelet volume; LUSC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg12564285 chr5:131593104 PDLIM4 0.32 5.7 0.3 2.68e-8 Blood metabolite levels; LUSC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg22467129 chr15:76604101 ETFA -0.45 -7.24 -0.37 3.05e-12 Blood metabolite levels; LUSC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.43 -7.25 -0.37 2.9e-12 Alzheimer's disease (late onset); LUSC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg03452623 chr4:187889614 NA -0.88 -18.62 -0.71 1.43e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs41271473 0.500 rs4440831 chr1:228887522 C/T cg10167378 chr1:228756711 NA -0.5 -7.01 -0.36 1.3e-11 Chronic lymphocytic leukemia; LUSC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg23711669 chr6:146136114 FBXO30 0.87 15.63 0.65 1.03e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg07424592 chr7:64974309 NA -0.4 -5.66 -0.3 3.23e-8 Calcium levels; LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg11645453 chr3:52864694 ITIH4 0.34 7.98 0.4 2.32e-14 Bipolar disorder; LUSC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg00033643 chr7:134001901 SLC35B4 0.47 7.39 0.37 1.19e-12 Mean platelet volume; LUSC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg06212747 chr3:49208901 KLHDC8B 0.44 5.96 0.31 6.46e-9 Parkinson's disease; LUSC cis rs559928 1.000 rs72926038 chr11:64142391 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 6.8 0.35 4.84e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2797160 0.967 rs6910786 chr6:126017141 A/T cg05901451 chr6:126070800 HEY2 0.57 8.55 0.42 4.43e-16 Endometrial cancer; LUSC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.42 0.46 7.6e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2820315 0.505 rs10800792 chr1:201811144 G/A cg11586189 chr1:201857591 SHISA4 0.34 5.9 0.31 8.86e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg13683864 chr3:40499215 RPL14 -1.14 -21.28 -0.76 3.91e-64 Renal cell carcinoma; LUSC trans rs6982636 1.000 rs2980869 chr8:126488250 C/T cg13325919 chr3:181432053 SOX2;SOX2OT -0.33 -6.32 -0.33 8.36e-10 Lipid metabolism phenotypes; LUSC cis rs12760731 0.668 rs12727134 chr1:178266794 T/C cg00404053 chr1:178313656 RASAL2 0.49 5.92 0.31 7.85e-9 Obesity-related traits; LUSC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg09034736 chr1:150693464 HORMAD1 -0.4 -5.69 -0.3 2.81e-8 Urate levels; LUSC cis rs67460515 0.892 rs34896809 chr3:161059804 C/T cg03342759 chr3:160939853 NMD3 -0.52 -7.45 -0.38 8.2e-13 Parkinson's disease; LUSC cis rs259282 0.605 rs73028624 chr19:33111758 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.68 10.08 0.48 4.82e-21 Schizophrenia; LUSC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg08677398 chr8:58056175 NA 0.52 6.4 0.33 5.13e-10 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg04025307 chr7:1156635 C7orf50 0.44 6.76 0.35 6.09e-11 Longevity;Endometriosis; LUSC cis rs354225 0.584 rs17046097 chr2:54888075 A/G cg26097391 chr2:54893211 SPTBN1 -0.44 -6.83 -0.35 4.03e-11 Schizophrenia; LUSC cis rs5757673 1 rs5757673 chr22:39837920 T/C cg05872129 chr22:39784769 NA -0.57 -9.51 -0.46 3.85e-19 Post bronchodilator FEV1; LUSC trans rs61931739 0.534 rs4931770 chr12:34044479 G/T cg13010199 chr12:38710504 ALG10B 0.55 8.36 0.42 1.74e-15 Morning vs. evening chronotype; LUSC cis rs4285028 0.847 rs1986712 chr3:121710986 A/G cg11130432 chr3:121712080 ILDR1 -0.68 -10.36 -0.49 5.34e-22 Multiple sclerosis; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.58 9.66 0.47 1.29e-19 Lymphocyte counts; LUSC cis rs9815354 0.812 rs73077359 chr3:41850016 G/A cg03022575 chr3:42003672 ULK4 0.86 8.66 0.43 2.07e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg18755752 chr8:142205143 DENND3 -0.54 -8.68 -0.43 1.72e-16 Immature fraction of reticulocytes; LUSC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg24733560 chr20:60626293 TAF4 0.41 6.73 0.35 7.47e-11 Body mass index; LUSC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.84 -0.3 1.23e-8 Tonsillectomy; LUSC cis rs6519955 0.860 rs8136098 chr22:46425646 A/G cg05468064 chr22:46423449 NA 0.41 6.88 0.35 2.92e-11 Dupuytren's disease; LUSC cis rs4555082 1.000 rs4277291 chr14:105759009 A/G cg10792982 chr14:105748885 BRF1 0.46 8.16 0.41 6.69e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs6964587 0.626 rs2106745 chr7:91506635 C/T cg17063962 chr7:91808500 NA -0.56 -9.21 -0.45 3.76e-18 Breast cancer; LUSC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg25767906 chr1:53392781 SCP2 -0.36 -6.35 -0.33 7.15e-10 Monocyte count; LUSC trans rs7937682 0.889 rs551825 chr11:111480116 C/G cg18187862 chr3:45730750 SACM1L 0.54 7.07 0.36 8.98e-12 Primary sclerosing cholangitis; LUSC cis rs7075426 0.905 rs11202038 chr10:88204877 C/T cg07322936 chr10:88137208 NA 0.54 8.22 0.41 4.65e-15 Migraine without aura; LUSC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.19e-30 Aortic root size; LUSC cis rs10908458 0.584 rs10908455 chr1:155067283 C/T cg23973274 chr1:155060172 NA 0.32 6.39 0.33 5.65e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4704187 0.687 rs12653162 chr5:74391666 C/T cg03227963 chr5:74354835 NA 0.32 6.82 0.35 4.21e-11 Response to amphetamines; LUSC cis rs4948275 0.550 rs7904815 chr10:63136612 G/A cg26296364 chr10:63212206 TMEM26 -0.35 -5.67 -0.3 3.09e-8 Night sleep phenotypes; LUSC cis rs6087771 0.714 rs6058259 chr20:30235302 A/G cg13852791 chr20:30311386 BCL2L1 0.86 12.03 0.55 6.28e-28 Subcortical brain region volumes;Putamen volume; LUSC cis rs7659604 0.540 rs28672860 chr4:122705051 G/A cg19748678 chr4:122722346 EXOSC9 -0.49 -7.29 -0.37 2.27e-12 Type 2 diabetes; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg08968635 chr6:28129556 ZNF389 0.45 5.78 0.3 1.73e-8 Parkinson's disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25937148 chr3:43147320 C3orf39 -0.37 -6.49 -0.33 3.04e-10 Electrocardiographic conduction measures; LUSC cis rs548987 0.529 rs1165164 chr6:25863481 G/A cg03517284 chr6:25882590 NA -0.39 -5.79 -0.3 1.58e-8 Homocysteine levels; LUSC cis rs5769707 0.609 rs2071890 chr22:50001291 G/A cg05373962 chr22:49881684 NA -0.39 -8.37 -0.42 1.58e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11864453 0.616 rs9938025 chr16:72022041 A/G cg01557791 chr16:72042693 DHODH 0.45 5.94 0.31 7.05e-9 Fibrinogen levels; LUSC cis rs7577851 0.625 rs12473304 chr2:69558112 C/T cg10773587 chr2:69614142 GFPT1 0.59 6.41 0.33 5.08e-10 Parkinson's disease (age of onset); LUSC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.68 -10.32 -0.49 7.46e-22 Monocyte percentage of white cells; LUSC cis rs6987853 0.686 rs55837592 chr8:42359974 T/C cg09913449 chr8:42400586 C8orf40 -0.44 -7.4 -0.38 1.13e-12 Mean corpuscular hemoglobin concentration; LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.54 9.06 0.44 1.11e-17 Prudent dietary pattern; LUSC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg06108461 chr20:60628389 TAF4 -0.74 -11.88 -0.54 2.19e-27 Body mass index; LUSC cis rs10089 0.953 rs3805615 chr5:127519049 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.55 0.53 3.55e-26 Ileal carcinoids; LUSC cis rs950776 0.684 rs692780 chr15:78876505 C/G cg06917634 chr15:78832804 PSMA4 -0.7 -11.27 -0.52 3.39e-25 Sudden cardiac arrest; LUSC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg06238570 chr21:40685208 BRWD1 0.46 7.1 0.36 7.38e-12 Cognitive function; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg18765753 chr7:1198926 ZFAND2A -0.4 -7.44 -0.38 8.48e-13 Longevity;Endometriosis; LUSC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg07959070 chr22:50026188 C22orf34 -0.34 -6.92 -0.35 2.34e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4141404 0.818 rs6518737 chr22:31582662 A/G cg22777020 chr22:31556080 RNF185 -0.47 -6.82 -0.35 4.36e-11 Paclitaxel-induced neuropathy; LUSC trans rs7937682 0.960 rs480293 chr11:111469132 A/C cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg05340658 chr4:99064831 C4orf37 0.65 10.82 0.51 1.34e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs62238980 0.614 rs17682385 chr22:32387572 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5.04e-9 Childhood ear infection; LUSC cis rs1322512 0.713 rs1028650 chr6:152938025 G/T cg27316956 chr6:152958899 SYNE1 -0.36 -5.94 -0.31 7.06e-9 Tonometry; LUSC cis rs4343996 0.747 rs1403158 chr7:3464896 A/G cg21248987 chr7:3385318 SDK1 0.34 5.73 0.3 2.27e-8 Motion sickness; LUSC trans rs7746199 0.736 rs13210634 chr6:27646492 A/G cg06606381 chr12:133084897 FBRSL1 -0.95 -8.61 -0.43 2.88e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg06636001 chr8:8085503 FLJ10661 0.6 9.22 0.45 3.5e-18 Mood instability; LUSC cis rs11997175 0.603 rs12234894 chr8:33699275 G/C ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.2e-10 Body mass index; LUSC cis rs5009270 0.512 rs75795332 chr7:112241690 G/A cg23628563 chr7:112262597 NA 0.43 5.93 0.31 7.36e-9 Osteoarthritis (hip); LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg24675658 chr1:53192096 ZYG11B 0.58 9.15 0.45 5.79e-18 Monocyte count; LUSC cis rs7824557 0.564 rs4631424 chr8:11236809 T/C cg21775007 chr8:11205619 TDH -0.65 -10.26 -0.49 1.22e-21 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.23 0.56 1.14e-28 Prudent dietary pattern; LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg23758822 chr17:41437982 NA 1.05 20.03 0.74 3.41e-59 Menopause (age at onset); LUSC cis rs453301 0.592 rs4841084 chr8:8883905 C/T cg11608241 chr8:8085544 FLJ10661 0.39 5.64 0.3 3.55e-8 Joint mobility (Beighton score); LUSC cis rs7647973 0.961 rs11130187 chr3:49307872 T/C cg07636037 chr3:49044803 WDR6 0.68 8.94 0.44 2.74e-17 Menarche (age at onset); LUSC cis rs10193935 0.901 rs72798529 chr2:42537471 C/T cg27598129 chr2:42591480 NA -0.6 -8.17 -0.41 6.36e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs6686643 0.868 rs9333461 chr1:165618320 G/T cg16553119 chr1:165599451 MGST3 -0.49 -7.65 -0.39 2.18e-13 Total ventricular volume; LUSC cis rs7000551 0.505 rs13258195 chr8:22227271 A/G cg12081754 chr8:22256438 SLC39A14 -0.87 -13.49 -0.59 2.12e-33 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2236521 0.659 rs72487383 chr20:60889313 A/C cg09594475 chr20:60884601 LAMA5 0.4 6.11 0.32 2.7e-9 Pelvic organ prolapse; LUSC cis rs7605827 0.930 rs10929372 chr2:15662434 A/G cg19274914 chr2:15703543 NA 0.48 9.3 0.45 1.82e-18 Educational attainment (years of education); LUSC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs4242434 0.757 rs2280104 chr8:22525980 C/T cg03733263 chr8:22462867 KIAA1967 0.9 15.72 0.65 4.75e-42 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC trans rs7572263 0.652 rs34575089 chr2:209047368 G/A cg21778348 chr7:27194614 HOXA7 -0.44 -6.07 -0.32 3.52e-9 Glioma;Non-glioblastoma glioma; LUSC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg11645453 chr3:52864694 ITIH4 0.35 8.21 0.41 4.87e-15 Bipolar disorder; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg01802117 chr1:53393560 SCP2 -0.39 -6.54 -0.34 2.27e-10 Monocyte count; LUSC cis rs7829975 0.755 rs3789849 chr8:8687054 G/C cg11608241 chr8:8085544 FLJ10661 0.4 5.78 0.3 1.69e-8 Mood instability; LUSC cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg04998671 chr14:104000505 TRMT61A -0.43 -6.32 -0.33 8.34e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.6 8.69 0.43 1.65e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg20476274 chr7:133979776 SLC35B4 -0.81 -14.42 -0.62 5.37e-37 Mean platelet volume; LUSC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg09263875 chr16:632152 PIGQ 0.7 13.01 0.58 1.41e-31 Height; LUSC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg27286337 chr10:134555280 INPP5A 0.9 11.61 0.54 2.01e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs6601327 0.641 rs11780399 chr8:9589167 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.43 -0.33 4.36e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs6977660 1.000 rs10279601 chr7:19822171 G/A cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs477692 0.597 rs574831 chr10:131379190 C/T cg05714579 chr10:131428358 MGMT -0.48 -7.03 -0.36 1.18e-11 Response to temozolomide; LUSC cis rs929354 0.772 rs10229630 chr7:157004790 C/T cg05182265 chr7:156933206 UBE3C -0.57 -9.21 -0.45 3.73e-18 Body mass index; LUSC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg06046430 chr4:77819534 ANKRD56 0.47 6.83 0.35 4.03e-11 Emphysema distribution in smoking; LUSC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg03806693 chr22:41940476 POLR3H 0.94 13.75 0.6 2.15e-34 Vitiligo; LUSC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg07274523 chr3:49395745 GPX1 0.63 10.42 0.5 3.38e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs367943 1.000 rs348962 chr5:112819086 C/T cg12552261 chr5:112820674 MCC 0.45 7.0 0.36 1.37e-11 Type 2 diabetes; LUSC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.11e-16 Schizophrenia; LUSC cis rs2294693 0.947 rs742492 chr6:40996381 G/A cg14769373 chr6:40998127 UNC5CL -0.55 -7.99 -0.4 2.15e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg18512352 chr11:47633146 NA 0.48 9.97 0.48 1.11e-20 Subjective well-being; LUSC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg24209194 chr3:40518798 ZNF619 0.43 5.85 0.3 1.2e-8 Renal cell carcinoma; LUSC cis rs9300255 0.739 rs4759415 chr12:123743674 C/T cg00376283 chr12:123451042 ABCB9 -0.65 -8.34 -0.42 1.97e-15 Neutrophil percentage of white cells; LUSC cis rs12190007 0.547 rs3006178 chr6:169823936 G/A ch.6.169577133F chr6:169835210 NA -0.38 -5.74 -0.3 2.15e-8 Obesity-related traits; LUSC trans rs6952808 0.582 rs11763870 chr7:2027448 T/C cg04565464 chr8:145669602 NFKBIL2 -0.42 -7.09 -0.36 8.11e-12 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.902 rs2144476 chr6:146322484 G/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.1e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs6076065 0.594 rs6048755 chr20:23337233 A/G cg11657817 chr20:23433608 CST11 0.55 11.08 0.52 1.66e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs250677 0.522 rs4705301 chr5:148354902 C/G cg12140854 chr5:148520817 ABLIM3 -0.38 -6.02 -0.31 4.68e-9 Breast cancer; LUSC cis rs7911264 0.967 rs2497318 chr10:94432000 C/T cg25093409 chr10:94429542 NA -0.39 -6.52 -0.34 2.6e-10 Inflammatory bowel disease; LUSC cis rs11018904 0.906 rs12793836 chr11:89953493 C/T cg26834418 chr11:89957033 CHORDC1 -0.5 -6.24 -0.32 1.34e-9 Intelligence (multi-trait analysis); LUSC cis rs9325144 0.624 rs10783333 chr12:39118931 A/T cg13010199 chr12:38710504 ALG10B 0.47 7.19 0.37 4.25e-12 Morning vs. evening chronotype; LUSC trans rs3857536 0.813 rs9354404 chr6:66948408 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs7402982 0.934 rs8028620 chr15:99202875 C/T cg03437748 chr15:99193247 IGF1R 0.54 8.54 0.42 4.81e-16 Birth weight; LUSC cis rs1448094 0.802 rs56391398 chr12:86424114 C/T cg00310523 chr12:86230176 RASSF9 0.38 6.96 0.36 1.79e-11 Major depressive disorder; LUSC cis rs17685 0.672 rs56343450 chr7:75796235 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9467711 0.606 rs9393708 chr6:26362643 C/T cg09904177 chr6:26538194 HMGN4 0.7 6.79 0.35 5.28e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg13047869 chr3:10149882 C3orf24 -0.6 -8.76 -0.43 9.71e-17 Alzheimer's disease; LUSC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.21 0.59 2.51e-32 Hip circumference adjusted for BMI; LUSC cis rs5769765 0.671 rs138817 chr22:50163058 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.64 -8.37 -0.42 1.56e-15 Schizophrenia; LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg05313129 chr8:58192883 C8orf71 -0.51 -5.75 -0.3 1.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg13395646 chr4:1353034 KIAA1530 0.49 6.93 0.35 2.14e-11 Obesity-related traits; LUSC cis rs7560272 0.588 rs4852965 chr2:73911169 T/C cg20560298 chr2:73613845 ALMS1 0.42 6.41 0.33 4.85e-10 Schizophrenia; LUSC cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg05868516 chr6:26286170 HIST1H4H 0.36 6.02 0.31 4.5e-9 Educational attainment; LUSC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg19592336 chr6:28129416 ZNF389 0.5 6.57 0.34 1.94e-10 Parkinson's disease; LUSC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg01503450 chr10:980765 NA -0.41 -5.81 -0.3 1.45e-8 Eosinophil percentage of granulocytes; LUSC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg07936489 chr17:37558343 FBXL20 0.72 10.08 0.48 4.9e-21 Glomerular filtration rate (creatinine); LUSC cis rs3849570 0.643 rs10779986 chr3:81970818 C/G cg07356753 chr3:81810745 GBE1 0.55 8.33 0.41 2.06e-15 Waist circumference;Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02263479 chr16:2097837 NTHL1;TSC2 -0.41 -6.15 -0.32 2.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg17264618 chr3:40429014 ENTPD3 -0.34 -7.34 -0.37 1.6e-12 Renal cell carcinoma; LUSC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg06221963 chr1:154839813 KCNN3 -0.63 -14.32 -0.62 1.37e-36 Prostate cancer; LUSC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg00343986 chr7:65444356 GUSB -0.42 -6.33 -0.33 8.09e-10 Aortic root size; LUSC cis rs826838 1.000 rs9795768 chr12:39012479 T/C cg13010199 chr12:38710504 ALG10B 0.69 11.51 0.53 4.95e-26 Heart rate; LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg19318889 chr4:1322082 MAEA -0.8 -14.56 -0.62 1.51e-37 Longevity; LUSC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg21699342 chr2:239360505 ASB1 0.55 10.09 0.48 4.41e-21 Multiple system atrophy; LUSC cis rs829883 0.932 rs249840 chr12:98871993 T/C cg25150519 chr12:98850993 NA 0.65 10.19 0.49 2.13e-21 Colorectal adenoma (advanced); LUSC cis rs397969 0.596 rs17605101 chr17:19877634 T/C cg13482628 chr17:19912719 NA 0.47 5.82 0.3 1.35e-8 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11950805 chr1:43824379 CDC20 -0.4 -6.14 -0.32 2.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg05472934 chr7:22766657 IL6 0.53 8.22 0.41 4.5e-15 Lung cancer; LUSC cis rs67696533 0.600 rs4911237 chr20:31122344 C/T cg13636640 chr20:31349939 DNMT3B 0.48 6.49 0.33 3.12e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg12311346 chr5:56204834 C5orf35 -0.92 -13.56 -0.6 1.09e-33 Initial pursuit acceleration; LUSC cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.98 0.44 2.08e-17 Motion sickness; LUSC cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.72e-10 Crohn's disease; LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.88 0.31 9.69e-9 Menopause (age at onset); LUSC cis rs9790314 1.000 rs2218803 chr3:161047973 T/G cg03342759 chr3:160939853 NMD3 -0.5 -8.32 -0.41 2.19e-15 Morning vs. evening chronotype; LUSC trans rs11039798 1.000 rs7123704 chr11:48580535 G/A cg03929089 chr4:120376271 NA 0.66 6.16 0.32 2.06e-9 Axial length; LUSC cis rs10186029 0.509 rs13426230 chr2:213940447 G/A cg08319019 chr2:214017104 IKZF2 -0.42 -6.12 -0.32 2.64e-9 Systemic sclerosis; LUSC trans rs11723530 0.538 rs7670130 chr4:170812566 C/T cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.16 -0.32 2.13e-9 Myopia (pathological); LUSC cis rs921968 0.643 rs545460 chr2:219392159 A/G cg02176678 chr2:219576539 TTLL4 0.61 10.98 0.51 3.82e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs478304 0.651 rs11532071 chr11:65500198 C/A cg10518572 chr11:65560635 OVOL1 -0.26 -6.01 -0.31 4.88e-9 Acne (severe); LUSC cis rs4631830 0.900 rs7914347 chr10:51537431 C/T cg16070123 chr10:51489643 NA -0.51 -8.04 -0.4 1.58e-14 Prostate-specific antigen levels; LUSC cis rs897984 0.609 rs35468353 chr16:31056433 A/G cg02466173 chr16:30829666 NA -0.53 -10.36 -0.49 5.3e-22 Dementia with Lewy bodies; LUSC cis rs10911363 0.592 rs2702182 chr1:183516440 C/T cg09173681 chr1:183549694 NCF2 0.6 10.57 0.5 9.95e-23 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14704079 chr4:140222620 NAA15 -0.42 -6.09 -0.32 3.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg01657329 chr11:68192670 LRP5 -0.44 -6.59 -0.34 1.73e-10 Total body bone mineral density; LUSC cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg17063962 chr7:91808500 NA 0.6 9.46 0.46 5.9e-19 Breast cancer; LUSC cis rs6460942 0.556 rs10228123 chr7:12374025 A/C cg06484146 chr7:12443880 VWDE -0.5 -6.12 -0.32 2.62e-9 Coronary artery disease; LUSC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg14552801 chr7:65878734 NA -0.46 -6.54 -0.34 2.31e-10 Aortic root size; LUSC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg24549020 chr5:56110836 MAP3K1 0.49 5.67 0.3 3.12e-8 Initial pursuit acceleration; LUSC cis rs11018904 0.817 rs11606060 chr11:89928597 T/C cg26138821 chr11:89956704 CHORDC1 -0.6 -6.87 -0.35 3.24e-11 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg06850241 chr22:41845214 NA -0.31 -5.71 -0.3 2.44e-8 Vitiligo; LUSC cis rs950169 0.922 rs12912934 chr15:85114447 C/T cg11189052 chr15:85197271 WDR73 0.47 5.83 0.3 1.28e-8 Schizophrenia; LUSC cis rs4654899 1.000 rs6426669 chr1:21430584 C/A cg01072550 chr1:21505969 NA -0.51 -7.8 -0.39 7.8e-14 Superior frontal gyrus grey matter volume; LUSC trans rs35110281 0.744 rs162398 chr21:44949285 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 10.09 0.48 4.47e-21 Mean corpuscular volume; LUSC cis rs7903847 0.673 rs61861870 chr10:99154339 G/T cg20016023 chr10:99160130 RRP12 -0.28 -6.03 -0.31 4.26e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg13852791 chr20:30311386 BCL2L1 0.91 12.42 0.56 2.22e-29 Mean corpuscular hemoglobin; LUSC cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg22676075 chr6:135203613 NA 0.57 9.06 0.44 1.1e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs11105298 0.891 rs10858909 chr12:89935387 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.14 -0.36 5.69e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9325144 0.555 rs6582607 chr12:38717678 T/C cg26384229 chr12:38710491 ALG10B -0.59 -9.14 -0.45 6.19e-18 Morning vs. evening chronotype; LUSC cis rs8048589 0.615 rs34147612 chr16:12233188 G/A cg02910054 chr16:12241554 SNX29 0.51 6.18 0.32 1.91e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs12545109 0.800 rs1913278 chr8:57403725 T/C cg09654669 chr8:57350985 NA -0.5 -6.48 -0.33 3.29e-10 Obesity-related traits; LUSC cis rs12410462 0.581 rs35141785 chr1:227553496 G/C cg04117972 chr1:227635322 NA 0.6 6.78 0.35 5.48e-11 Major depressive disorder; LUSC cis rs5770917 1.000 rs1557503 chr22:51013072 G/A cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.61 -5.72 -0.3 2.43e-8 Narcolepsy; LUSC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg04267008 chr7:1944627 MAD1L1 -0.52 -7.81 -0.39 7.23e-14 Bipolar disorder and schizophrenia; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.04 -0.4 1.55e-14 Lymphocyte counts; LUSC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg10755058 chr3:40428713 ENTPD3 0.36 5.97 0.31 5.99e-9 Renal cell carcinoma; LUSC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.8e-10 Schizophrenia; LUSC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg25036284 chr2:26402008 FAM59B -0.69 -9.6 -0.47 1.93e-19 Gut microbiome composition (summer); LUSC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg09367891 chr1:107599246 PRMT6 0.55 8.69 0.43 1.65e-16 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs13315871 0.929 rs76226186 chr3:58318499 C/T cg20936604 chr3:58311152 NA -0.77 -7.1 -0.36 7.59e-12 Cholesterol, total; LUSC cis rs1595825 1.000 rs73058829 chr2:198871145 G/A cg00982548 chr2:198649783 BOLL -0.49 -6.15 -0.32 2.15e-9 Ulcerative colitis; LUSC cis rs7923609 0.811 rs7899657 chr10:65323265 G/A cg01631684 chr10:65280961 REEP3 0.4 5.85 0.3 1.19e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg24558204 chr6:135376177 HBS1L -0.46 -6.63 -0.34 1.34e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.14 -0.49 3.06e-21 Menarche (age at onset); LUSC cis rs2777491 1.000 rs1757455 chr15:41761332 G/T cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.34 -0.59 7.96e-33 Ulcerative colitis; LUSC cis rs1499972 0.941 rs62263120 chr3:117630253 A/G cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.95e-8 Schizophrenia; LUSC cis rs11992162 0.967 rs10112888 chr8:11830208 G/C cg21775007 chr8:11205619 TDH 0.53 7.51 0.38 5.6e-13 Monocyte count; LUSC cis rs7903847 0.642 rs10882910 chr10:99138043 G/A cg20016023 chr10:99160130 RRP12 -0.34 -8.25 -0.41 3.65e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs4631830 0.720 rs2125771 chr10:51506957 C/T cg10326726 chr10:51549505 MSMB -0.37 -6.42 -0.33 4.7e-10 Prostate-specific antigen levels; LUSC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.7 0.3 2.6e-8 Self-reported allergy; LUSC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg17173187 chr15:85201210 NMB 0.36 6.45 0.33 3.83e-10 Schizophrenia; LUSC cis rs6918586 0.616 rs198836 chr6:26113616 T/A cg17691542 chr6:26056736 HIST1H1C 0.4 6.03 0.31 4.38e-9 Schizophrenia; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg01517273 chr1:154599968 ADAR 0.48 6.36 0.33 6.48e-10 Cognitive function;Information processing speed; LUSC cis rs4663866 1.000 rs4663868 chr2:239161091 C/T cg16914508 chr2:239161102 PER2 0.68 7.14 0.36 5.87e-12 Irritable bowel syndrome; LUSC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 5.89 0.31 9.6e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs9300255 0.739 rs4759371 chr12:123742563 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.24 -0.32 1.35e-9 Neutrophil percentage of white cells; LUSC trans rs7726839 0.540 rs72703080 chr5:595238 A/G cg11887960 chr12:57824829 NA 0.54 6.63 0.34 1.32e-10 Obesity-related traits; LUSC cis rs11018904 0.906 rs35129016 chr11:89948689 T/C cg26834418 chr11:89957033 CHORDC1 -0.53 -6.37 -0.33 6.08e-10 Intelligence (multi-trait analysis); LUSC cis rs453301 0.686 rs11785819 chr8:8870378 T/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.64 -0.39 2.38e-13 Joint mobility (Beighton score); LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg11645453 chr3:52864694 ITIH4 0.34 7.68 0.39 1.76e-13 Bipolar disorder; LUSC cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg00071950 chr4:10020882 SLC2A9 0.66 11.13 0.52 1.13e-24 Bone mineral density; LUSC cis rs10089 0.857 rs7718286 chr5:127459414 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.67 0.54 1.25e-26 Ileal carcinoids; LUSC cis rs7712401 0.584 rs4836382 chr5:122376641 G/A cg19077854 chr5:122220652 SNX24 0.36 7.28 0.37 2.35e-12 Mean platelet volume; LUSC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs317689 0.680 rs315140 chr12:69790780 A/T cg14784868 chr12:69753453 YEATS4 0.59 7.8 0.39 7.87e-14 Response to diuretic therapy; LUSC cis rs6696846 0.630 rs11240373 chr1:205135600 A/C cg21643547 chr1:205240462 TMCC2 -0.39 -6.77 -0.35 5.96e-11 Red blood cell count; LUSC cis rs77106637 0.932 rs74439784 chr11:72649396 A/T cg03878208 chr11:72483293 STARD10 0.58 7.76 0.39 1.07e-13 Type 2 diabetes; LUSC trans rs2797160 0.602 rs4897150 chr6:125985540 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.47 -7.03 -0.36 1.16e-11 Endometrial cancer; LUSC cis rs593982 0.920 rs521678 chr11:65485727 T/G cg08755490 chr11:65554678 OVOL1 1.5 13.22 0.59 2.31e-32 Atopic dermatitis; LUSC cis rs17685 0.753 rs4398845 chr7:75716781 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.69 -0.39 1.71e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10779751 1.000 rs2253213 chr1:11265785 A/G cg08854313 chr1:11322531 MTOR 0.86 14.27 0.62 2.14e-36 Body mass index; LUSC cis rs7149337 0.805 rs3007164 chr14:51646935 A/G cg23942311 chr14:51606299 NA 0.49 10.96 0.51 4.45e-24 Cancer; LUSC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs41271473 1.000 rs6665334 chr1:228868574 A/C cg10167378 chr1:228756711 NA 0.55 6.58 0.34 1.84e-10 Chronic lymphocytic leukemia; LUSC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg02569458 chr12:86230093 RASSF9 0.59 9.96 0.48 1.28e-20 Major depressive disorder; LUSC cis rs1160297 0.576 rs1376569 chr2:53087260 C/T cg07782112 chr2:53107842 NA 0.4 6.5 0.34 2.87e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg07636037 chr3:49044803 WDR6 1.05 18.99 0.72 4.92e-55 Parkinson's disease; LUSC cis rs6964587 0.900 rs11984136 chr7:91766953 T/C cg01689657 chr7:91764605 CYP51A1 0.31 5.67 0.3 3.11e-8 Breast cancer; LUSC cis rs7072216 0.652 rs11189600 chr10:100179274 A/G cg26618903 chr10:100175079 PYROXD2 0.31 6.01 0.31 4.77e-9 Metabolite levels; LUSC cis rs9395066 0.509 rs11967188 chr6:44956925 C/T cg25276700 chr6:44698697 NA 0.28 5.8 0.3 1.55e-8 Height; LUSC cis rs4889855 0.614 rs7221663 chr17:78484166 T/C cg00066239 chr17:78472159 NA -0.43 -7.23 -0.37 3.4e-12 Fractional excretion of uric acid; LUSC cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg04450456 chr4:17643702 FAM184B 0.36 6.07 0.32 3.5e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2011503 0.941 rs76944848 chr19:19417512 C/T cg15839431 chr19:19639596 YJEFN3 -0.62 -6.32 -0.33 8.31e-10 Bipolar disorder; LUSC cis rs57481061 1 rs57481061 chr12:90019178 C/G cg00757033 chr12:89920650 WDR51B 0.51 6.73 0.35 7.41e-11 Coronary artery disease; LUSC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 16.98 0.68 4.78e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1953600 0.668 rs7091565 chr10:81913561 A/G cg00277334 chr10:82204260 NA -0.39 -5.96 -0.31 6.55e-9 Sarcoidosis; LUSC cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg10523679 chr1:76189770 ACADM 0.66 9.12 0.45 6.95e-18 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01439340 chr17:79369256 NA -0.43 -6.35 -0.33 6.92e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7727544 0.557 rs715285 chr5:131485383 A/G cg14196790 chr5:131705035 SLC22A5 0.44 7.58 0.38 3.49e-13 Blood metabolite levels; LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg14893161 chr1:205819251 PM20D1 0.86 15.8 0.65 2.15e-42 Menarche (age at onset); LUSC cis rs9341808 0.754 rs9343973 chr6:80913216 A/G cg08355045 chr6:80787529 NA 0.58 10.2 0.49 1.97e-21 Sitting height ratio; LUSC cis rs4356932 0.967 rs6835736 chr4:76962494 A/T cg00809888 chr4:76862425 NAAA 0.36 6.12 0.32 2.68e-9 Blood protein levels; LUSC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg00339695 chr16:24857497 SLC5A11 0.41 7.1 0.36 7.74e-12 Intelligence (multi-trait analysis); LUSC cis rs509477 0.662 rs273343 chr18:32604173 G/C cg23791764 chr18:32556832 MAPRE2 0.39 5.65 0.3 3.42e-8 Cerebrospinal fluid AB1-42 levels; LUSC trans rs11992162 0.597 rs6996342 chr8:11784541 C/T cg14343924 chr8:8086146 FLJ10661 -0.44 -6.0 -0.31 5.09e-9 Monocyte count; LUSC cis rs12478296 1.000 rs73007129 chr2:243000555 T/C cg06360820 chr2:242988706 NA -1.06 -10.79 -0.51 1.68e-23 Obesity-related traits; LUSC cis rs3942852 0.955 rs1910364 chr11:48113232 A/G cg20307385 chr11:47447363 PSMC3 0.5 5.81 0.3 1.49e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs4604732 0.631 rs34330532 chr1:247626844 G/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs897080 0.552 rs1067383 chr2:44645911 C/T cg00619915 chr2:44497795 NA -0.4 -5.83 -0.3 1.3e-8 Height; LUSC cis rs367615 0.704 rs7726991 chr5:108847434 C/T cg17395555 chr5:108820864 NA 0.6 11.27 0.52 3.59e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs7584330 0.554 rs74001386 chr2:238425333 T/A cg16989719 chr2:238392110 NA -0.43 -6.15 -0.32 2.25e-9 Prostate cancer; LUSC trans rs2832077 1.000 rs9983229 chr21:30137674 A/G cg14791747 chr16:20752902 THUMPD1 -0.72 -9.74 -0.47 6.82e-20 Cognitive test performance; LUSC cis rs2562456 0.516 rs56072098 chr19:21651960 G/T cg00806126 chr19:22604979 ZNF98 0.37 5.98 0.31 5.78e-9 Pain; LUSC cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg08807101 chr21:30365312 RNF160 0.79 14.9 0.63 7.27e-39 Dental caries; LUSC cis rs765787 0.530 rs1706764 chr15:45524256 T/A cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.5e-17 Uric acid levels; LUSC cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs57590327 0.555 rs6767749 chr3:81725513 G/A cg07356753 chr3:81810745 GBE1 -0.67 -10.42 -0.5 3.49e-22 Extraversion; LUSC cis rs2235649 0.663 rs6600167 chr16:1848912 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -5.92 -0.31 7.81e-9 Blood metabolite levels; LUSC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg00012203 chr2:219082015 ARPC2 -0.7 -11.41 -0.53 1.08e-25 Colorectal cancer; LUSC cis rs7119 0.717 rs11636412 chr15:77767291 C/T cg05673287 chr15:77411982 SGK269 -0.44 -6.97 -0.36 1.7e-11 Type 2 diabetes; LUSC cis rs977987 0.843 rs67409275 chr16:75457212 T/C cg04384234 chr16:75411784 CFDP1 -0.45 -7.41 -0.38 1.07e-12 Dupuytren's disease; LUSC cis rs2404602 0.575 rs11072611 chr15:76947983 A/G cg23625390 chr15:77176239 SCAPER 0.64 9.54 0.46 3.23e-19 Blood metabolite levels; LUSC cis rs4144743 1.000 rs7218524 chr17:45326565 A/G cg18085866 chr17:45331354 ITGB3 -0.75 -7.79 -0.39 8.26e-14 Body mass index; LUSC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.64 0.5 5.72e-23 Homoarginine levels; LUSC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg09367891 chr1:107599246 PRMT6 -0.48 -7.73 -0.39 1.27e-13 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs11098499 0.644 rs2389880 chr4:120559870 T/A cg24375607 chr4:120327624 NA 0.71 11.07 0.52 1.74e-24 Corneal astigmatism; LUSC cis rs7107174 1.000 rs10899483 chr11:78061057 G/C cg02023728 chr11:77925099 USP35 0.42 6.34 0.33 7.44e-10 Testicular germ cell tumor; LUSC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg01191920 chr7:158217561 PTPRN2 -0.52 -10.81 -0.51 1.5e-23 Obesity-related traits; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg04234412 chr22:24373322 LOC391322 -0.86 -14.05 -0.61 1.5e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2667011 0.697 rs7584941 chr2:160831263 A/G cg06573604 chr2:160760825 LY75 -0.5 -6.24 -0.32 1.3e-9 Bilirubin levels; LUSC cis rs9811920 0.809 rs1387647 chr3:99826942 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 6.63 0.34 1.35e-10 Axial length; LUSC cis rs57590327 0.503 rs9880844 chr3:81507217 C/T cg07356753 chr3:81810745 GBE1 0.46 6.07 0.32 3.47e-9 Extraversion; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg25767906 chr1:53392781 SCP2 0.53 9.75 0.47 6.33e-20 Monocyte count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14162034 chr15:78112026 NA -0.48 -6.29 -0.33 1.01e-9 Bipolar disorder and schizophrenia; LUSC cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg16230307 chr14:35515116 FAM177A1 0.78 10.0 0.48 8.96e-21 Psoriasis; LUSC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg03538708 chr1:25844672 NA -0.39 -6.36 -0.33 6.76e-10 Erythrocyte sedimentation rate; LUSC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg16624210 chr5:671434 TPPP 0.49 6.25 0.32 1.23e-9 Obesity-related traits; LUSC cis rs5758659 0.700 rs739294 chr22:42381726 T/C cg04733989 chr22:42467013 NAGA 0.39 6.29 0.33 1e-9 Cognitive function; LUSC cis rs12950390 0.853 rs4793647 chr17:45854090 G/C cg06532163 chr17:45867833 NA 0.34 6.41 0.33 4.93e-10 IgG glycosylation; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg01411255 chr17:61851458 DDX42;CCDC47 -0.68 -11.35 -0.53 1.8e-25 Prudent dietary pattern; LUSC cis rs6964587 0.967 rs6973896 chr7:91778465 A/G cg17063962 chr7:91808500 NA 0.6 9.63 0.47 1.55e-19 Breast cancer; LUSC cis rs714027 0.837 rs713875 chr22:30592487 C/G cg11564601 chr22:30592435 NA -0.41 -7.61 -0.38 2.85e-13 Lymphocyte counts; LUSC trans rs2204008 0.837 rs7301679 chr12:37989629 T/C cg06521331 chr12:34319734 NA 0.4 6.28 0.32 1.05e-9 Bladder cancer; LUSC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg03806693 chr22:41940476 POLR3H -1.06 -15.03 -0.64 2.29e-39 Vitiligo; LUSC cis rs7647973 0.626 rs11709734 chr3:49745235 G/A cg13072238 chr3:49761600 GMPPB -0.64 -8.14 -0.41 8.05e-15 Menarche (age at onset); LUSC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -8.68 -0.43 1.83e-16 Schizophrenia; LUSC cis rs7177699 0.557 rs72749206 chr15:79122948 G/A cg00540400 chr15:79124168 NA -0.47 -7.97 -0.4 2.46e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg09904177 chr6:26538194 HMGN4 0.66 11.71 0.54 8.69e-27 Intelligence (multi-trait analysis); LUSC cis rs921968 0.528 rs13022583 chr2:219589175 T/C cg02176678 chr2:219576539 TTLL4 -0.58 -10.3 -0.49 8.75e-22 Mean corpuscular hemoglobin concentration; LUSC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg14298792 chr15:30685198 CHRFAM7A -0.69 -8.87 -0.44 4.43e-17 Huntington's disease progression; LUSC cis rs8060686 0.623 rs58388686 chr16:68075439 A/G cg05110241 chr16:68378359 PRMT7 -0.43 -5.69 -0.3 2.79e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.19e-9 Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17861791 chr1:113162073 ST7L;CAPZA1 0.42 6.29 0.33 1.01e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.635 rs6058375 chr20:34531997 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.03 -0.44 1.45e-17 Total cholesterol levels; LUSC cis rs12893668 0.703 rs12894729 chr14:104035292 G/A cg04998671 chr14:104000505 TRMT61A -0.47 -6.66 -0.34 1.14e-10 Reticulocyte count; LUSC cis rs477692 0.699 rs576175 chr10:131386408 A/T cg11019008 chr10:131425282 MGMT 0.4 5.86 0.31 1.11e-8 Response to temozolomide; LUSC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg24829409 chr8:58192753 C8orf71 -0.62 -6.43 -0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs7020 chr20:25278600 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.05 0.74 3.05e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6088580 0.524 rs6088552 chr20:33226491 A/G cg08999081 chr20:33150536 PIGU -0.41 -7.58 -0.38 3.34e-13 Glomerular filtration rate (creatinine); LUSC cis rs11105298 0.891 rs3825330 chr12:89933710 C/T cg00757033 chr12:89920650 WDR51B 0.6 10.47 0.5 2.28e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs17401966 1.000 rs12136376 chr1:10296452 C/T cg19773385 chr1:10388646 KIF1B -0.54 -8.42 -0.42 1.11e-15 Hepatocellular carcinoma; LUSC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg23093090 chr10:104574429 C10orf26 -0.37 -6.82 -0.35 4.16e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg18305652 chr10:134549665 INPP5A 0.46 6.63 0.34 1.35e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.24 0.52 4.44e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg04546413 chr19:29218101 NA 0.71 11.45 0.53 7.79e-26 Methadone dose in opioid dependence; LUSC cis rs8017423 0.967 rs60548738 chr14:90724399 G/A cg14092571 chr14:90743983 NA -0.36 -5.82 -0.3 1.35e-8 Mortality in heart failure; LUSC cis rs4631830 0.863 rs2611508 chr10:51518047 T/A cg20129853 chr10:51489980 NA -0.33 -6.44 -0.33 4.05e-10 Prostate-specific antigen levels; LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg17968037 chr7:100024898 ZCWPW1 -0.4 -5.89 -0.31 9.45e-9 Platelet count; LUSC cis rs17401966 0.838 rs4333852 chr1:10387704 A/T cg19773385 chr1:10388646 KIF1B 0.5 8.98 0.44 2.08e-17 Hepatocellular carcinoma; LUSC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg06484146 chr7:12443880 VWDE -0.67 -6.91 -0.35 2.47e-11 Coronary artery disease; LUSC cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg16797656 chr11:68205561 LRP5 0.35 5.92 0.31 8.03e-9 Total body bone mineral density; LUSC cis rs5769765 0.908 rs138889 chr22:50226673 T/C cg02269571 chr22:50332266 NA -0.55 -8.23 -0.41 4.28e-15 Schizophrenia; LUSC cis rs9296092 0.538 rs9296094 chr6:33520064 A/G cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.77e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg04518342 chr5:131593106 PDLIM4 0.4 7.33 0.37 1.73e-12 Breast cancer; LUSC cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.38 -0.46 1.07e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs11098499 0.754 rs10212714 chr4:120254302 T/C cg24375607 chr4:120327624 NA 0.78 12.78 0.57 1e-30 Corneal astigmatism; LUSC cis rs4909189 0.957 rs71547529 chr7:158135469 G/T cg06219351 chr7:158114137 PTPRN2 -0.53 -8.34 -0.42 1.93e-15 Response to amphetamines; LUSC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -6.04 -0.31 4.01e-9 Total body bone mineral density; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11904960 chr17:35716418 ACACA -0.45 -7.03 -0.36 1.17e-11 Electrocardiographic conduction measures; LUSC cis rs7945718 0.806 rs11022507 chr11:12829753 A/T cg25843174 chr11:12811716 TEAD1 0.29 6.51 0.34 2.76e-10 Educational attainment (years of education); LUSC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg18681998 chr4:17616180 MED28 -0.86 -15.12 -0.64 1.08e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10489202 0.954 rs3820399 chr1:168062053 C/T cg24449463 chr1:168025552 DCAF6 -0.57 -6.99 -0.36 1.51e-11 Schizophrenia; LUSC cis rs9399135 0.816 rs4134030 chr6:135354094 G/T cg24558204 chr6:135376177 HBS1L 0.59 9.2 0.45 4.06e-18 Red blood cell count; LUSC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg10220895 chr1:228464137 OBSCN 0.32 5.94 0.31 7.12e-9 Diastolic blood pressure; LUSC cis rs6977660 0.507 rs4719580 chr7:19784847 G/T cg07541023 chr7:19748670 TWISTNB 0.61 6.46 0.33 3.63e-10 Thyroid stimulating hormone; LUSC trans rs7647973 0.626 rs1996664 chr3:49878395 A/G cg21659725 chr3:3221576 CRBN 0.72 8.67 0.43 1.92e-16 Menarche (age at onset); LUSC cis rs72781680 0.898 rs72796152 chr2:23933626 G/A cg20701182 chr2:24300061 SF3B14 0.55 5.65 0.3 3.47e-8 Lymphocyte counts; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23604961 chr13:108870525 LIG4;ABHD13 -0.44 -6.48 -0.33 3.26e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.4 -0.38 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7705502 1.000 rs7736263 chr5:173339222 G/T cg18693985 chr5:173351052 CPEB4 -0.36 -5.75 -0.3 2.01e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.88e-19 Developmental language disorder (linguistic errors); LUSC cis rs1670533 0.932 rs2248083 chr4:1052166 A/C cg27284194 chr4:1044797 NA 0.54 7.66 0.39 1.98e-13 Recombination rate (females); LUSC cis rs7809950 0.678 rs77395658 chr7:107000651 G/A cg23024343 chr7:107201750 COG5 -0.66 -9.9 -0.48 1.99e-20 Coronary artery disease; LUSC cis rs8141529 0.732 rs2347447 chr22:29179739 C/A cg15103426 chr22:29168792 CCDC117 0.6 8.35 0.42 1.87e-15 Lymphocyte counts; LUSC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg05585544 chr11:47624801 NA -0.41 -7.22 -0.37 3.43e-12 Subjective well-being; LUSC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg02269571 chr22:50332266 NA -0.6 -8.95 -0.44 2.57e-17 Schizophrenia; LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg07507251 chr3:52567010 NT5DC2 0.36 6.94 0.36 2.04e-11 Bipolar disorder; LUSC cis rs57920188 0.703 rs10915642 chr1:4089244 T/C cg20703997 chr1:4087676 NA 0.54 8.16 0.41 7.11e-15 Interleukin-17 levels; LUSC cis rs67696533 0.600 rs3746614 chr20:31108477 C/T cg13636640 chr20:31349939 DNMT3B 0.49 6.74 0.35 6.83e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs1355223 0.573 rs7127169 chr11:34727846 C/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.13 -0.32 2.55e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11605924 0.901 rs11038672 chr11:45846498 C/G ch.11.939596F chr11:45881766 CRY2 -0.5 -7.35 -0.37 1.54e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg21782813 chr7:2030301 MAD1L1 0.37 6.1 0.32 2.99e-9 Schizophrenia; LUSC cis rs9660992 1.000 rs9660992 chr1:205249450 A/G cg21545522 chr1:205238299 TMCC2 0.42 7.94 0.4 3.01e-14 Mean corpuscular volume;Mean platelet volume; LUSC cis rs3126085 0.935 rs3120660 chr1:152258701 G/T cg26876637 chr1:152193138 HRNR -0.46 -6.38 -0.33 6.03e-10 Atopic dermatitis; LUSC cis rs7572644 0.621 rs4464229 chr2:28038080 C/T cg27432699 chr2:27873401 GPN1 0.58 7.37 0.37 1.36e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7103648 0.618 rs11039284 chr11:47564785 A/G cg20307385 chr11:47447363 PSMC3 0.85 12.16 0.55 2.09e-28 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs1729951 0.575 rs361245 chr3:136695706 A/G cg21827317 chr3:136751795 NA 0.37 6.65 0.34 1.16e-10 Neuroticism; LUSC cis rs6961069 0.621 rs6973242 chr7:80238793 C/T cg04458919 chr7:80252533 CD36 -0.4 -7.15 -0.36 5.43e-12 Platelet count; LUSC cis rs929354 0.742 rs2051877 chr7:157008813 A/T cg17757837 chr7:157058334 UBE3C 0.82 13.2 0.59 2.61e-32 Body mass index; LUSC cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.19 0.49 2.03e-21 Schizophrenia; LUSC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.66 0.5 4.85e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11122272 0.735 rs2808597 chr1:231532351 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.27 -0.49 1.14e-21 Hemoglobin concentration; LUSC trans rs6982636 0.967 rs2980854 chr8:126477497 C/T cg13325919 chr3:181432053 SOX2;SOX2OT -0.35 -6.68 -0.34 1e-10 Lipid metabolism phenotypes; LUSC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.54 0.5 1.27e-22 Menopause (age at onset); LUSC cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg06784218 chr1:46089804 CCDC17 0.48 9.36 0.46 1.18e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg03036452 chr22:46663545 TTC38 0.53 5.78 0.3 1.72e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs240764 0.559 rs9404049 chr6:101237129 C/A cg09795085 chr6:101329169 ASCC3 -0.45 -6.46 -0.33 3.75e-10 Neuroticism; LUSC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg06637938 chr14:75390232 RPS6KL1 0.54 8.71 0.43 1.44e-16 Height; LUSC trans rs11039798 0.841 rs11500573 chr11:48713900 T/G cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs10779751 0.734 rs2486920 chr1:11125050 T/C cg04508216 chr1:11107452 MASP2 0.33 5.89 0.31 9.32e-9 Body mass index; LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg09877947 chr5:131593287 PDLIM4 0.49 8.45 0.42 9.13e-16 Blood metabolite levels; LUSC cis rs7572644 0.699 rs7593127 chr2:28258027 G/A cg27432699 chr2:27873401 GPN1 -0.52 -7.07 -0.36 9.22e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs11785400 1.000 rs6988393 chr8:143740596 A/G cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC cis rs8072100 0.967 rs11871606 chr17:45732774 G/T cg25173405 chr17:45401733 C17orf57 0.38 6.06 0.31 3.65e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs524023 0.914 rs2360873 chr11:64391157 G/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.39 -0.49 4.28e-22 Urate levels in obese individuals; LUSC cis rs909674 0.775 rs8138462 chr22:39839670 G/C cg01416388 chr22:39784598 NA -0.43 -6.73 -0.35 7.48e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs1775715 0.966 rs1755066 chr10:32309160 C/G cg26784012 chr10:32216390 ARHGAP12 -0.38 -6.15 -0.32 2.27e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg07606381 chr6:8435919 SLC35B3 0.72 12.03 0.55 5.89e-28 Motion sickness; LUSC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg20295408 chr7:1910781 MAD1L1 -0.49 -6.88 -0.35 3.02e-11 Bipolar disorder and schizophrenia; LUSC cis rs7927771 0.524 rs10838739 chr11:47672743 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -6.67 -0.34 1.09e-10 Subjective well-being; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21044797 chr8:142138325 DENND3 0.7 6.24 0.32 1.33e-9 Cognitive performance; LUSC cis rs11048434 0.736 rs12424026 chr12:9110993 T/C cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC cis rs12984174 0.877 rs408484 chr19:18139771 C/T cg21649277 chr19:18117794 ARRDC2 0.72 7.58 0.38 3.38e-13 Pulmonary function in asthmatics; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04789776 chr8:22462112 KIAA1967 0.76 6.65 0.34 1.21e-10 Cognitive performance; LUSC cis rs2386661 0.547 rs11259582 chr10:5646767 C/T cg17085576 chr10:5658249 NA -0.43 -6.37 -0.33 6.09e-10 Breast cancer; LUSC cis rs1559088 0.947 rs7259879 chr19:33549462 T/C cg27124370 chr19:33622961 WDR88 0.52 6.73 0.35 7.56e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01129155 chr16:33817129 NA 0.43 6.05 0.31 3.95e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4295623 0.559 rs2409836 chr8:11689228 T/G cg06636001 chr8:8085503 FLJ10661 0.5 7.18 0.37 4.49e-12 Morning vs. evening chronotype; LUSC cis rs11030122 0.702 rs1452047 chr11:3991648 A/C cg08557956 chr11:4115526 RRM1 -0.47 -5.91 -0.31 8.67e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs9309473 0.519 rs2421586 chr2:73899719 C/T cg20560298 chr2:73613845 ALMS1 0.47 7.06 0.36 9.61e-12 Metabolite levels; LUSC cis rs922692 0.744 rs2277545 chr15:79083591 T/C cg00540400 chr15:79124168 NA -0.41 -7.1 -0.36 7.6e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs3858526 0.834 rs10838989 chr11:5978057 A/G cg25319279 chr11:5960081 NA -0.45 -6.32 -0.33 8.2e-10 DNA methylation (variation); LUSC cis rs7712401 0.601 rs396941 chr5:122318265 G/T cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg18876405 chr7:65276391 NA 0.76 13.72 0.6 2.85e-34 Aortic root size; LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg18099408 chr3:52552593 STAB1 -0.4 -6.85 -0.35 3.62e-11 Bipolar disorder; LUSC cis rs9309473 0.851 rs6546850 chr2:73831147 A/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.63 -0.34 1.37e-10 Metabolite levels; LUSC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg06634786 chr22:41940651 POLR3H -0.57 -6.56 -0.34 2.08e-10 Vitiligo; LUSC cis rs1595825 0.891 rs79845692 chr2:198523541 T/C cg19156104 chr2:198669113 PLCL1 -0.45 -5.69 -0.3 2.74e-8 Ulcerative colitis; LUSC cis rs240764 0.658 rs2132168 chr6:101178491 G/A cg09795085 chr6:101329169 ASCC3 -0.45 -6.56 -0.34 2.04e-10 Neuroticism; LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg16325326 chr1:53192061 ZYG11B -0.9 -16.97 -0.68 4.92e-47 Monocyte count; LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg11062466 chr8:58055876 NA 0.75 9.1 0.45 8.12e-18 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg23583168 chr7:148888333 NA -0.87 -16.03 -0.66 2.6900000000000002e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.71 0.34 8.26e-11 Lung cancer; LUSC cis rs6426558 0.524 rs2813948 chr1:227459621 A/T cg10327440 chr1:227177885 CDC42BPA 0.55 7.43 0.38 8.94e-13 Neutrophil percentage of white cells; LUSC cis rs2694528 0.844 rs9291696 chr5:60064385 C/T cg11474532 chr5:59995715 DEPDC1B 0.86 7.9 0.4 3.98e-14 Parkinson's disease; LUSC cis rs11756438 0.572 rs2638550 chr6:118998481 C/G cg18833306 chr6:118973337 C6orf204 0.36 5.73 0.3 2.2e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16204370 chr22:41682343 RANGAP1 -0.44 -6.47 -0.33 3.53e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4714291 0.722 rs9296320 chr6:40118298 C/G cg02267698 chr19:7991119 CTXN1 0.52 8.21 0.41 4.97e-15 Strep throat; LUSC cis rs17270561 0.609 rs9358887 chr6:25759406 G/T cg16482183 chr6:26056742 HIST1H1C 0.59 8.04 0.4 1.54e-14 Iron status biomarkers; LUSC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg08677398 chr8:58056175 NA 0.52 6.35 0.33 7.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9359856 0.517 rs112527288 chr6:90509141 C/T cg13799429 chr6:90582589 CASP8AP2 -0.84 -8.33 -0.41 2.13e-15 Bipolar disorder; LUSC cis rs35110281 0.627 rs1436291 chr21:44965485 T/C cg01579765 chr21:45077557 HSF2BP -0.46 -9.72 -0.47 8.01e-20 Mean corpuscular volume; LUSC trans rs7819412 0.715 rs35223712 chr8:11043926 C/T cg15556689 chr8:8085844 FLJ10661 -0.56 -8.09 -0.4 1.1e-14 Triglycerides; LUSC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg13393036 chr8:95962371 TP53INP1 -0.44 -9.2 -0.45 3.88e-18 Type 2 diabetes; LUSC cis rs4594175 0.926 rs4901084 chr14:51634131 G/A cg23942311 chr14:51606299 NA 0.3 5.68 0.3 2.86e-8 Cancer; LUSC cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.94 -0.36 2.02e-11 Menopause (age at onset); LUSC trans rs12902680 0.706 rs12437760 chr15:46525644 T/C cg04321580 chr8:143696133 ARC -0.42 -6.0 -0.31 5e-9 Neuroticism; LUSC cis rs790123 0.965 rs2133850 chr3:122381696 C/T cg00926285 chr3:122398533 PARP14 -0.38 -5.84 -0.3 1.21e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs11864453 0.645 rs7194668 chr16:72128207 G/C cg01557791 chr16:72042693 DHODH -0.44 -6.31 -0.33 8.75e-10 Fibrinogen levels; LUSC cis rs8077889 0.917 rs4793037 chr17:41914826 C/T cg26893861 chr17:41843967 DUSP3 0.92 14.26 0.62 2.34e-36 Triglycerides; LUSC cis rs25645 0.502 rs7223318 chr17:38108553 G/C cg26162295 chr17:38119207 GSDMA -0.28 -6.33 -0.33 8.07e-10 Myeloid white cell count; LUSC cis rs432925 0.600 rs214249 chr16:348687 T/G cg06233593 chr16:337645 AXIN1 0.45 8.5 0.42 6.51e-16 Morning vs. evening chronotype; LUSC trans rs61931739 0.817 rs592857 chr12:34197673 T/G cg13010199 chr12:38710504 ALG10B 0.41 6.49 0.33 3.06e-10 Morning vs. evening chronotype; LUSC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg09359103 chr1:154839909 KCNN3 -0.71 -16.53 -0.67 2.9e-45 Prostate cancer; LUSC cis rs12421382 0.543 rs11213094 chr11:109357926 G/A cg11473876 chr11:109292803 C11orf87 0.42 6.48 0.33 3.26e-10 Schizophrenia; LUSC cis rs765787 0.530 rs12917187 chr15:45538297 A/G cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC cis rs1018836 0.608 rs2205150 chr8:91483232 G/A cg16814680 chr8:91681699 NA -0.59 -8.73 -0.43 1.27e-16 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg01879757 chr17:41196368 BRCA1 -0.39 -5.95 -0.31 6.79e-9 Menopause (age at onset); LUSC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg12698349 chr2:225449008 CUL3 -0.71 -9.64 -0.47 1.42e-19 IgE levels in asthmatics (D.p. specific); LUSC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg02034447 chr16:89574710 SPG7 0.43 6.28 0.32 1.07e-9 Multiple myeloma (IgH translocation); LUSC cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg01657329 chr11:68192670 LRP5 -0.42 -6.31 -0.33 8.78e-10 Total body bone mineral density; LUSC cis rs1018836 0.923 rs12545726 chr8:91532087 T/A cg16814680 chr8:91681699 NA -0.75 -12.14 -0.55 2.47e-28 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs11992162 0.933 rs10108075 chr8:11832079 A/G cg06636001 chr8:8085503 FLJ10661 0.58 8.28 0.41 2.98e-15 Monocyte count; LUSC cis rs6681460 0.608 rs10889624 chr1:67005807 A/G cg02459107 chr1:67143332 SGIP1 0.38 6.37 0.33 6.44e-10 Presence of antiphospholipid antibodies; LUSC cis rs7940866 0.770 rs10791104 chr11:130814893 A/T cg12179176 chr11:130786555 SNX19 0.64 9.7 0.47 9.07e-20 Schizophrenia; LUSC cis rs11864453 0.647 rs7194397 chr16:72128299 C/T cg01557791 chr16:72042693 DHODH -0.45 -6.6 -0.34 1.6e-10 Fibrinogen levels; LUSC trans rs961253 0.556 rs6038446 chr20:6331883 G/A cg17788362 chr6:86352627 SYNCRIP 0.41 6.0 0.31 5.01e-9 Colorectal cancer; LUSC cis rs11155671 0.530 rs9371542 chr6:150213085 A/T cg07701084 chr6:150067640 NUP43 0.47 6.99 0.36 1.52e-11 Testicular germ cell tumor; LUSC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg06634786 chr22:41940651 POLR3H 0.51 6.05 0.31 3.96e-9 Vitiligo; LUSC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg12432903 chr7:1882776 MAD1L1 0.51 6.25 0.32 1.23e-9 Bipolar disorder; LUSC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs11098499 0.708 rs10005237 chr4:120237897 T/C cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05195750 chr11:31531557 ELP4;IMMP1L 0.44 6.21 0.32 1.53e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28595532 1.000 rs41455648 chr4:119718030 A/G cg14228332 chr4:119757509 SEC24D 0.74 5.65 0.3 3.39e-8 Cannabis dependence symptom count; LUSC cis rs317689 0.690 rs547827 chr12:69669703 G/A cg11871910 chr12:69753446 YEATS4 0.46 6.03 0.31 4.26e-9 Response to diuretic therapy; LUSC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg14784868 chr12:69753453 YEATS4 0.91 16.11 0.66 1.33e-43 Cerebrospinal fluid biomarker levels; LUSC cis rs3960554 0.808 rs3779419 chr7:75695081 G/A cg17325771 chr7:75508891 RHBDD2 -0.4 -5.88 -0.31 9.93e-9 Eotaxin levels; LUSC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg20476274 chr7:133979776 SLC35B4 0.81 14.5 0.62 2.68e-37 Mean platelet volume; LUSC cis rs67366981 1.000 rs8006732 chr14:77713070 T/G cg22824376 chr14:77648248 TMEM63C 0.63 6.17 0.32 1.97e-9 Obsessive-compulsive symptoms; LUSC cis rs9926296 0.632 rs4785716 chr16:89801127 T/C cg26513180 chr16:89883248 FANCA 0.58 8.9 0.44 3.62e-17 Vitiligo; LUSC cis rs7223966 1.000 rs9901112 chr17:61730617 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 6.44 0.33 4.16e-10 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs656319 0.513 rs17746227 chr8:9981654 T/C cg21775007 chr8:11205619 TDH -0.48 -6.56 -0.34 2.06e-10 Myopia (pathological); LUSC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.04 0.52 2.31e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs11122272 0.735 rs2808592 chr1:231523757 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg15556689 chr8:8085844 FLJ10661 0.6 9.58 0.46 2.29e-19 Mood instability; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.72 11.08 0.52 1.63e-24 Lymphocyte counts; LUSC cis rs1538970 0.962 rs2298018 chr1:45813441 T/C cg05343316 chr1:45956843 TESK2 0.59 8.2 0.41 5.17e-15 Platelet count; LUSC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg08219700 chr8:58056026 NA 0.66 7.44 0.38 8.4e-13 Developmental language disorder (linguistic errors); LUSC cis rs11711311 1.000 rs6792447 chr3:113508335 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -5.97 -0.31 6.04e-9 IgG glycosylation; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg27284194 chr4:1044797 NA 0.34 5.65 0.3 3.38e-8 Obesity-related traits; LUSC cis rs35123781 0.502 rs261532 chr5:138949362 A/C cg11459648 chr5:138714337 SLC23A1 0.49 7.57 0.38 3.66e-13 Schizophrenia; LUSC cis rs8028313 0.630 rs12438118 chr15:67951150 A/C cg08079166 chr15:68083412 MAP2K5 -0.35 -6.08 -0.32 3.23e-9 Obesity; LUSC cis rs68170813 0.559 rs10953530 chr7:106827796 A/C cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.7 -0.3 2.61e-8 Coronary artery disease; LUSC cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg12011299 chr4:100065546 ADH4 0.71 10.85 0.51 1.08e-23 Smoking initiation; LUSC cis rs7215564 0.908 rs34267318 chr17:78664619 G/A cg23238734 chr17:78661607 RPTOR 0.48 6.12 0.32 2.63e-9 Myopia (pathological); LUSC cis rs6459804 1.000 rs6459806 chr7:157510483 C/G cg05731713 chr7:157510257 PTPRN2 0.48 9.29 0.45 1.99e-18 Bipolar disorder and schizophrenia; LUSC cis rs1577917 0.796 rs12661231 chr6:86544471 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.35 -0.33 7.15e-10 Response to antipsychotic treatment; LUSC cis rs1215050 0.740 rs783936 chr4:98928628 G/T cg03676636 chr4:99064102 C4orf37 -0.27 -5.81 -0.3 1.45e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4566357 0.790 rs4389330 chr2:227957483 C/G cg11843606 chr2:227700838 RHBDD1 0.49 7.18 0.37 4.54e-12 Coronary artery disease; LUSC cis rs7833787 1.000 rs7844375 chr8:18703258 A/G cg17701159 chr8:18705777 PSD3 -0.38 -6.21 -0.32 1.55e-9 Obesity-related traits; LUSC cis rs12042938 1.000 rs4366301 chr1:231806286 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.43 -6.29 -0.33 9.73e-10 Neuranatomic and neurocognitive phenotypes; LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg08888203 chr3:10149979 C3orf24 -0.63 -9.14 -0.45 6.24e-18 Alzheimer's disease; LUSC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.75e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2637266 1.000 rs1077916 chr10:78381951 G/A cg18941641 chr10:78392320 NA 0.37 6.67 0.34 1.08e-10 Pulmonary function; LUSC cis rs965513 0.932 rs10818050 chr9:100538923 A/G cg13688889 chr9:100608707 NA -0.57 -8.58 -0.42 3.68e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs1371867 0.810 rs1692004 chr8:101247320 T/C cg00191853 chr8:101177733 SPAG1 0.36 5.82 0.3 1.39e-8 Atrioventricular conduction; LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg27284194 chr4:1044797 NA 0.36 5.87 0.31 1.07e-8 Obesity-related traits; LUSC cis rs2235649 0.789 rs9939680 chr16:1852720 C/T cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -5.9 -0.31 9.08e-9 Blood metabolite levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21528620 chr1:110753221 KCNC4 -0.52 -6.85 -0.35 3.53e-11 Bipolar disorder and schizophrenia; LUSC cis rs1577917 0.958 rs34795473 chr6:86461799 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.89 -0.44 3.87e-17 Response to antipsychotic treatment; LUSC cis rs854765 0.693 rs9907246 chr17:17770965 T/C cg09796270 chr17:17721594 SREBF1 -0.44 -7.77 -0.39 1.01e-13 Total body bone mineral density; LUSC cis rs2404602 0.692 rs35195096 chr15:76938447 C/T cg23625390 chr15:77176239 SCAPER 0.45 6.9 0.35 2.55e-11 Blood metabolite levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27079446 chr18:3449844 TGIF1 -0.55 -7.27 -0.37 2.59e-12 Bipolar disorder and schizophrenia; LUSC cis rs8060686 0.545 rs3826164 chr16:68280317 A/G cg27539214 chr16:67997921 SLC12A4 0.55 6.57 0.34 1.96e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.63 0.39 2.55e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg25456477 chr12:86230367 RASSF9 0.39 6.86 0.35 3.45e-11 Major depressive disorder; LUSC trans rs4714291 0.928 rs761799 chr6:39990050 T/A cg02267698 chr19:7991119 CTXN1 0.53 7.48 0.38 6.51e-13 Strep throat; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.71 11.72 0.54 8.33e-27 Prudent dietary pattern; LUSC trans rs7615952 0.576 rs17523380 chr3:125802874 C/T cg07211511 chr3:129823064 LOC729375 -0.62 -8.42 -0.42 1.1e-15 Blood pressure (smoking interaction); LUSC cis rs6545883 0.965 rs9989775 chr2:61761774 A/G cg15711740 chr2:61764176 XPO1 -0.5 -7.84 -0.39 6.11e-14 Tuberculosis; LUSC cis rs12369179 0.737 rs116896792 chr12:122948907 T/C cg18578876 chr12:123200353 GPR109B -0.89 -7.07 -0.36 9.32e-12 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; LUSC trans rs17807624 0.780 rs13277929 chr8:11453030 G/A cg15556689 chr8:8085844 FLJ10661 0.49 7.04 0.36 1.11e-11 Systemic lupus erythematosus; LUSC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.6 8.49 0.42 6.68e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg26384229 chr12:38710491 ALG10B 0.86 14.37 0.62 8.39e-37 Bladder cancer; LUSC cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg26384229 chr12:38710491 ALG10B 0.89 15.27 0.64 2.63e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg08270630 chr22:50330655 NA -0.39 -5.79 -0.3 1.64e-8 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00544901 chr19:49999417 RPS11 0.39 6.53 0.34 2.51e-10 Triglycerides; LUSC cis rs3772130 0.583 rs4296627 chr3:121567684 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.83 13.54 0.6 1.29e-33 Cognitive performance; LUSC trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.62 -0.43 2.8e-16 Neuroticism; LUSC cis rs8114671 0.836 rs6142280 chr20:33622242 A/C cg07148914 chr20:33460835 GGT7 -0.44 -6.59 -0.34 1.68e-10 Height; LUSC cis rs472402 0.580 rs11134173 chr5:6659696 C/A cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.43 -6.2 -0.32 1.66e-9 Response to amphetamines; LUSC cis rs2197308 0.655 rs1971964 chr12:37870474 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.99 0.66 3.88e-43 Morning vs. evening chronotype; LUSC cis rs11690935 0.632 rs2292816 chr2:172586714 G/C cg13550731 chr2:172543902 DYNC1I2 0.6 9.48 0.46 4.73e-19 Schizophrenia; LUSC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg22549504 chr19:17448937 GTPBP3 0.56 7.36 0.37 1.42e-12 Systemic lupus erythematosus; LUSC cis rs1865760 0.516 rs9393684 chr6:26075531 G/C cg16482183 chr6:26056742 HIST1H1C 0.57 8.61 0.43 2.91e-16 Height; LUSC cis rs6960043 0.818 rs13220985 chr7:15062694 A/G cg19272540 chr7:15055459 NA 0.33 8.01 0.4 1.91e-14 Type 2 diabetes; LUSC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg12863693 chr15:85201151 NMB -0.27 -6.16 -0.32 2.06e-9 P wave terminal force; LUSC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg20295408 chr7:1910781 MAD1L1 -0.43 -6.1 -0.32 2.95e-9 Schizophrenia; LUSC cis rs58785573 0.570 rs4833078 chr4:38646476 C/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.49 7.45 0.38 8.27e-13 Lymphocyte percentage of white cells; LUSC cis rs7572644 0.713 rs4666020 chr2:28046028 A/G cg27432699 chr2:27873401 GPN1 -0.58 -7.55 -0.38 4.12e-13 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs911119 0.913 rs6048929 chr20:23588855 T/C cg16589663 chr20:23618590 CST3 0.56 6.77 0.35 5.68e-11 Chronic kidney disease; LUSC cis rs9393777 1.000 rs9393777 chr6:26942027 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.45 -5.97 -0.31 5.96e-9 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs2489039 chr10:102328036 T/A cg23241863 chr10:102295624 HIF1AN 0.5 5.87 0.31 1.05e-8 Palmitoleic acid (16:1n-7) levels; LUSC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg04282206 chr17:62833786 PLEKHM1P 0.41 6.03 0.31 4.44e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg06238570 chr21:40685208 BRWD1 -0.46 -7.06 -0.36 9.46e-12 Cognitive function; LUSC cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs4654899 0.733 rs10442633 chr1:21265097 C/T cg01072550 chr1:21505969 NA -0.53 -7.99 -0.4 2.25e-14 Superior frontal gyrus grey matter volume; LUSC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg19592336 chr6:28129416 ZNF389 0.46 6.36 0.33 6.55e-10 Parkinson's disease; LUSC cis rs7584330 0.737 rs6431540 chr2:238360966 T/C cg16989719 chr2:238392110 NA -0.37 -6.42 -0.33 4.56e-10 Prostate cancer; LUSC cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg24642439 chr20:33292090 TP53INP2 0.53 8.19 0.41 5.73e-15 Coronary artery disease; LUSC cis rs2637266 0.775 rs2579744 chr10:78311824 A/G cg18941641 chr10:78392320 NA 0.4 7.07 0.36 9.2e-12 Pulmonary function; LUSC cis rs2637266 0.935 rs2583055 chr10:78400029 C/T cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg08470875 chr2:26401718 FAM59B -0.69 -9.34 -0.46 1.39e-18 Gut microbiome composition (summer); LUSC cis rs10992471 0.627 rs10820980 chr9:95253342 C/T cg14631576 chr9:95140430 CENPP -0.33 -5.96 -0.31 6.48e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.71 0.39 1.49e-13 Vitiligo; LUSC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg04450456 chr4:17643702 FAM184B 0.4 6.7 0.34 8.68e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17401966 0.838 rs4529713 chr1:10307295 A/G cg19773385 chr1:10388646 KIF1B -0.53 -9.26 -0.45 2.63e-18 Hepatocellular carcinoma; LUSC cis rs870825 0.655 rs2017101 chr4:185637381 G/A cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC cis rs1577917 0.917 rs13196576 chr6:86534066 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs79387448 0.576 rs11902044 chr2:102972534 C/T cg09003973 chr2:102972529 NA 1.21 12.76 0.57 1.2e-30 Gut microbiota (bacterial taxa); LUSC cis rs7246657 0.943 rs7255785 chr19:37971683 C/T cg23950597 chr19:37808831 NA -0.62 -7.43 -0.38 9.32e-13 Coronary artery calcification; LUSC cis rs5769765 0.908 rs138889 chr22:50226673 T/C cg26441486 chr22:50317300 CRELD2 0.53 8.0 0.4 2.07e-14 Schizophrenia; LUSC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg06238570 chr21:40685208 BRWD1 -0.63 -10.61 -0.5 7.24e-23 Cognitive function; LUSC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg01475377 chr6:109611718 NA -0.41 -7.38 -0.37 1.24e-12 Reticulocyte fraction of red cells; LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -7.32 -0.37 1.85e-12 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs10844862 chr12:34531965 A/T cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.27 0.37 2.64e-12 Cognitive ability; LUSC cis rs11792861 0.926 rs1051474 chr9:111881856 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.89 -0.35 2.75e-11 Menarche (age at onset); LUSC trans rs11764590 0.715 rs56289396 chr7:2091415 G/A cg10840412 chr1:235813424 GNG4 0.51 6.18 0.32 1.87e-9 Neuroticism; LUSC cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg25182066 chr10:30743637 MAP3K8 -0.48 -6.63 -0.34 1.36e-10 Inflammatory bowel disease; LUSC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg13072238 chr3:49761600 GMPPB 0.38 6.18 0.32 1.83e-9 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.68 -10.71 -0.51 3.23e-23 Menarche (age at onset); LUSC cis rs617219 0.889 rs1717565 chr5:78440369 T/C cg24856658 chr5:78533917 JMY -0.3 -5.76 -0.3 1.87e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg13206674 chr6:150067644 NUP43 0.49 7.53 0.38 4.88e-13 Lung cancer; LUSC cis rs7617480 0.616 rs7429596 chr3:48808531 T/C cg07636037 chr3:49044803 WDR6 0.9 11.69 0.54 1.04e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg24829409 chr8:58192753 C8orf71 -0.62 -7.56 -0.38 3.95e-13 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.33 0.53 2.06e-25 Prudent dietary pattern; LUSC cis rs1775715 0.677 rs2799034 chr10:32175896 A/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.66 0.34 1.14e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs886126 0.684 rs3809288 chr12:111652522 G/A cg10833066 chr12:111807467 FAM109A 0.4 6.23 0.32 1.44e-9 Coronary heart disease; LUSC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg26314531 chr2:26401878 FAM59B -0.69 -9.31 -0.45 1.74e-18 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.56e-16 Developmental language disorder (linguistic errors); LUSC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg01475377 chr6:109611718 NA 0.46 8.43 0.42 1.03e-15 Reticulocyte fraction of red cells; LUSC cis rs908922 0.676 rs945788 chr1:152512762 A/G cg20991723 chr1:152506922 NA 0.5 9.34 0.45 1.44e-18 Hair morphology; LUSC cis rs1506636 0.646 rs805778 chr7:123214655 C/T cg03229431 chr7:123269106 ASB15 -0.6 -9.11 -0.45 8.02e-18 Plateletcrit;Platelet count; LUSC cis rs7927592 0.913 rs2236708 chr11:68378045 G/A cg01657329 chr11:68192670 LRP5 -0.39 -5.69 -0.3 2.82e-8 Total body bone mineral density; LUSC cis rs6688613 0.685 rs2235184 chr1:166870528 A/G cg07049167 chr1:166818506 POGK -0.44 -6.12 -0.32 2.69e-9 Refractive astigmatism; LUSC cis rs2806561 0.765 rs1757046 chr1:23511821 T/C cg12483005 chr1:23474871 LUZP1 0.42 6.59 0.34 1.71e-10 Height; LUSC cis rs1662342 1.000 rs16944555 chr18:3252130 T/C cg00760847 chr18:3262519 MYL12B -0.59 -5.74 -0.3 2.16e-8 QRS duration; LUSC cis rs782590 0.837 rs2627769 chr2:55927288 G/C cg18811423 chr2:55921094 PNPT1 0.88 15.45 0.65 5.27e-41 Metabolic syndrome; LUSC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.56 -8.6 -0.43 3.23e-16 Lymphocyte counts; LUSC cis rs12760731 0.565 rs6701848 chr1:178156816 A/C cg00404053 chr1:178313656 RASAL2 0.64 6.48 0.33 3.34e-10 Obesity-related traits; LUSC cis rs9322817 0.691 rs6571207 chr6:105242161 A/C cg02098413 chr6:105308735 HACE1 -0.28 -5.77 -0.3 1.79e-8 Thyroid stimulating hormone; LUSC cis rs3862030 0.720 rs11593583 chr10:104228149 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.57 8.87 0.44 4.6e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs9296092 0.538 rs35381461 chr6:33519751 T/C cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs1982963 0.613 rs2749885 chr14:52516567 T/G cg05884192 chr14:52515736 NID2 -0.23 -5.94 -0.31 7.15e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7621025 0.599 rs13063987 chr3:136445397 C/G cg15507776 chr3:136538369 TMEM22 -0.42 -5.77 -0.3 1.85e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs612683 0.524 rs479269 chr1:100887616 A/G cg06223162 chr1:101003688 GPR88 0.43 7.85 0.39 5.71e-14 Breast cancer; LUSC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs1371867 0.846 rs2083499 chr8:101230534 T/A cg06636551 chr8:101224915 SPAG1 0.47 8.76 0.43 9.83e-17 Atrioventricular conduction; LUSC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18404041 chr3:52824283 ITIH1 -0.55 -10.64 -0.5 5.81e-23 Electroencephalogram traits; LUSC cis rs782590 0.729 rs706548 chr2:55850106 C/G cg03859395 chr2:55845619 SMEK2 0.77 13.33 0.59 8.66e-33 Metabolic syndrome; LUSC cis rs3754214 0.769 rs509345 chr1:150276022 A/G cg15654264 chr1:150340011 RPRD2 -0.44 -7.29 -0.37 2.22e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.66 -6.31 -0.33 8.68e-10 Cerebrospinal P-tau181p levels; LUSC cis rs240764 0.658 rs705585 chr6:101262409 A/G cg09795085 chr6:101329169 ASCC3 0.44 6.54 0.34 2.34e-10 Neuroticism; LUSC cis rs17407555 0.606 rs73229818 chr4:10019884 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -6.25 -0.32 1.28e-9 Schizophrenia (age at onset); LUSC cis rs2730245 0.527 rs2709858 chr7:158675266 C/G cg11984989 chr7:158649758 WDR60 1.12 13.38 0.59 5.62e-33 Height; LUSC cis rs473651 0.935 rs558924 chr2:239339511 A/G cg21699342 chr2:239360505 ASB1 0.43 6.61 0.34 1.56e-10 Multiple system atrophy; LUSC cis rs12458462 0.892 rs58675823 chr18:77463672 G/A cg11879182 chr18:77439856 CTDP1 0.73 12.02 0.55 6.42e-28 Monocyte count; LUSC cis rs11785400 1.000 rs3735999 chr8:143746069 T/C cg24634471 chr8:143751801 JRK 0.6 9.08 0.45 9.55e-18 Schizophrenia; LUSC cis rs7216064 1.000 rs7208663 chr17:65885171 T/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs61931739 0.500 rs6488215 chr12:34434803 A/T cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.35e-33 Morning vs. evening chronotype; LUSC cis rs244293 1.000 rs244296 chr17:53242878 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.9 -0.31 8.75e-9 Menarche (age at onset); LUSC cis rs6690583 0.623 rs6672362 chr1:85454881 C/G cg22153463 chr1:85462885 MCOLN2 0.62 6.0 0.31 5.12e-9 Serum sulfate level; LUSC cis rs9650315 0.929 rs7001649 chr8:57169520 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs858239 0.571 rs6953020 chr7:23172132 T/C cg23682824 chr7:23144976 KLHL7 0.4 5.8 0.3 1.51e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.4 0.46 8.83e-19 Menarche (age at onset); LUSC cis rs61990749 0.597 rs8016447 chr14:78222068 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.63 6.67 0.34 1.08e-10 Fibroblast growth factor basic levels; LUSC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg00310523 chr12:86230176 RASSF9 0.42 7.88 0.4 4.52e-14 Major depressive disorder; LUSC cis rs6951245 0.678 rs4724725 chr7:1214751 G/A cg08132940 chr7:1081526 C7orf50 -0.5 -5.98 -0.31 5.89e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7605827 0.930 rs12995776 chr2:15717131 T/A cg19274914 chr2:15703543 NA 0.46 8.74 0.43 1.15e-16 Educational attainment (years of education); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19945092 chr10:27149349 ABI1 0.78 6.11 0.32 2.72e-9 Cognitive performance; LUSC cis rs2580764 0.540 rs2920893 chr2:55270629 C/T cg09592903 chr2:55203963 RTN4 0.5 10.14 0.49 3.06e-21 Mean platelet volume; LUSC cis rs3020736 0.500 rs6002601 chr22:42489058 A/T cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs10089 0.951 rs56066100 chr5:127460571 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.99 0.55 8.74e-28 Ileal carcinoids; LUSC cis rs7084921 0.533 rs12765091 chr10:101855231 G/C cg11888571 chr10:102027403 CWF19L1 -0.43 -5.96 -0.31 6.29e-9 Bone mineral density; LUSC cis rs7824557 0.592 rs2572371 chr8:11223793 G/T cg21775007 chr8:11205619 TDH 0.75 12.79 0.57 8.95e-31 Retinal vascular caliber; LUSC cis rs877282 0.945 rs71491311 chr10:791747 G/A cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.12 0.32 2.59e-9 Hip circumference adjusted for BMI; LUSC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg02475777 chr4:1388615 CRIPAK 0.42 6.38 0.33 5.76e-10 Obesity-related traits; LUSC cis rs7903847 0.642 rs6584128 chr10:99171926 G/T cg20016023 chr10:99160130 RRP12 0.31 7.6 0.38 3.02e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07690290 chr12:66524581 LLPH 0.72 6.09 0.32 3.05e-9 Cognitive performance; LUSC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.01 -0.31 4.79e-9 Total body bone mineral density; LUSC cis rs7107174 1.000 rs2510041 chr11:77945284 G/A cg02023728 chr11:77925099 USP35 0.48 7.13 0.36 6.4e-12 Testicular germ cell tumor; LUSC cis rs9811920 0.516 rs793486 chr3:99493165 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.3 -5.7 -0.3 2.6e-8 Axial length; LUSC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.56 5.92 0.31 7.82e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs9929218 1.000 rs7200690 chr16:68778457 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -12.35 -0.56 3.9e-29 Colorectal cancer; LUSC trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg03929089 chr4:120376271 NA 0.83 11.27 0.52 3.58e-25 Coronary artery disease; LUSC cis rs1577917 0.883 rs2660575 chr6:86684995 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.24 -0.32 1.35e-9 Response to antipsychotic treatment; LUSC cis rs4285028 0.747 rs1463736 chr3:121400725 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.81 -0.57 8.07e-31 Multiple sclerosis; LUSC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg06462663 chr19:18546047 ISYNA1 0.47 7.86 0.4 5.38e-14 Breast cancer; LUSC cis rs2832077 0.527 rs9981922 chr21:30212718 A/G cg08807101 chr21:30365312 RNF160 -0.53 -8.35 -0.42 1.88e-15 Cognitive test performance; LUSC cis rs61931739 0.500 rs11615231 chr12:34413330 T/C cg06521331 chr12:34319734 NA -0.4 -6.24 -0.32 1.29e-9 Morning vs. evening chronotype; LUSC cis rs4727027 0.704 rs12535154 chr7:148895304 G/A cg23158103 chr7:148848205 ZNF398 -0.51 -8.78 -0.43 8.7e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg14196790 chr5:131705035 SLC22A5 0.46 7.4 0.38 1.13e-12 Breast cancer;Mosquito bite size; LUSC cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg24596788 chr1:163392923 NA -0.43 -7.4 -0.38 1.13e-12 Motion sickness; LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg08132940 chr7:1081526 C7orf50 -0.52 -6.27 -0.32 1.11e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7617773 0.817 rs9834095 chr3:48327751 G/A cg11946769 chr3:48343235 NME6 0.86 13.87 0.6 7.36e-35 Coronary artery disease; LUSC cis rs2236918 1.000 rs1635515 chr1:242017009 A/G cg17736920 chr1:242011382 EXO1 0.45 7.12 0.36 6.71e-12 Menopause (age at onset); LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg01879757 chr17:41196368 BRCA1 -0.46 -6.96 -0.36 1.78e-11 Menopause (age at onset); LUSC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg00745463 chr17:30367425 LRRC37B -0.7 -8.56 -0.42 4.07e-16 Hip circumference adjusted for BMI; LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.26 0.64 2.89e-40 Platelet count; LUSC cis rs7246967 0.673 rs28787949 chr19:22830356 A/G cg23217946 chr19:22817039 ZNF492 0.48 6.8 0.35 4.73e-11 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.26e-9 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg09365446 chr1:150670422 GOLPH3L 0.47 7.0 0.36 1.4e-11 Melanoma; LUSC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.5 0.56 1.14e-29 Motion sickness; LUSC cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.77 -13.52 -0.59 1.62e-33 Strep throat; LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg13047869 chr3:10149882 C3orf24 0.6 8.23 0.41 4.23e-15 Alzheimer's disease; LUSC cis rs13315871 0.858 rs13090428 chr3:58314412 A/G cg20936604 chr3:58311152 NA -0.73 -7.06 -0.36 9.42e-12 Cholesterol, total; LUSC cis rs7020830 0.931 rs7027473 chr9:37132462 A/G cg14294708 chr9:37120828 ZCCHC7 1.12 26.67 0.82 9.47e-85 Schizophrenia; LUSC cis rs9426691 1 rs9426691 chr1:23484904 A/G cg12483005 chr1:23474871 LUZP1 0.47 6.58 0.34 1.86e-10 Coenzyme Q10 levels; LUSC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg07636037 chr3:49044803 WDR6 1.04 18.26 0.71 3.94e-52 Parkinson's disease; LUSC cis rs11098499 0.863 rs6858592 chr4:120458692 G/A cg24375607 chr4:120327624 NA 0.78 11.41 0.53 1.14e-25 Corneal astigmatism; LUSC cis rs9462027 0.628 rs6937132 chr6:34799221 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.79 -0.3 1.6e-8 Systemic lupus erythematosus; LUSC cis rs6539288 0.803 rs7307895 chr12:107332126 A/C cg26297688 chr12:107349093 C12orf23 -0.32 -5.74 -0.3 2.09e-8 Total body bone mineral density; LUSC cis rs7927592 0.913 rs10047412 chr11:68232912 T/C cg16797656 chr11:68205561 LRP5 0.37 6.08 0.32 3.27e-9 Total body bone mineral density; LUSC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.66 8.46 0.42 8.77e-16 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03946452 chr6:34393990 RPS10 -0.46 -6.87 -0.35 3.23e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg11494091 chr17:61959527 GH2 0.64 13.56 0.6 1.13e-33 Prudent dietary pattern; LUSC trans rs11992162 0.560 rs13276386 chr8:11797421 T/A cg27411982 chr8:10470053 RP1L1 0.42 6.33 0.33 7.88e-10 Monocyte count; LUSC cis rs9372498 0.572 rs62422230 chr6:118959436 T/C cg18833306 chr6:118973337 C6orf204 -0.46 -5.84 -0.3 1.24e-8 Diastolic blood pressure; LUSC cis rs7572733 0.534 rs770662 chr2:198729283 T/C cg00792783 chr2:198669748 PLCL1 0.43 5.68 0.3 2.9e-8 Dermatomyositis; LUSC cis rs2806561 0.734 rs11578046 chr1:23425139 G/A cg19743168 chr1:23544995 NA 0.43 8.06 0.4 1.41e-14 Height; LUSC trans rs11039798 1.000 rs6485908 chr11:48652198 C/T cg15704280 chr7:45808275 SEPT13 -0.65 -6.15 -0.32 2.2e-9 Axial length; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg00149659 chr3:10157352 C3orf10 0.91 12.44 0.56 1.89e-29 Alzheimer's disease; LUSC cis rs11112613 0.713 rs4015312 chr12:105948757 A/G cg03607813 chr12:105948248 NA 0.83 11.85 0.54 2.7e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs10740039 0.883 rs7905018 chr10:62407343 T/C cg18175470 chr10:62150864 ANK3 -0.46 -6.91 -0.35 2.5e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs295140 0.903 rs7605146 chr2:201183888 A/G cg04283868 chr2:201171347 SPATS2L -0.41 -6.12 -0.32 2.57e-9 QT interval; LUSC cis rs6426558 0.537 rs689094 chr1:227308909 G/A cg10327440 chr1:227177885 CDC42BPA 0.55 7.48 0.38 6.75e-13 Neutrophil percentage of white cells; LUSC cis rs1691799 0.867 rs6581677 chr12:66770379 C/G cg16791601 chr12:66731901 HELB -0.67 -11.83 -0.54 3.36e-27 White blood cell count (basophil); LUSC cis rs9815354 1.000 rs73081364 chr3:41913616 G/C cg03022575 chr3:42003672 ULK4 0.61 6.69 0.34 9.3e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs17401966 1.000 rs11578788 chr1:10422958 A/G cg19773385 chr1:10388646 KIF1B -0.53 -8.23 -0.41 4.24e-15 Hepatocellular carcinoma; LUSC cis rs12594515 0.967 rs11070465 chr15:45984899 A/G cg01629716 chr15:45996671 NA 0.4 6.08 0.32 3.26e-9 Waist circumference;Weight; LUSC cis rs6714710 0.603 rs17488897 chr2:98365164 G/C cg26665480 chr2:98280029 ACTR1B 0.64 9.1 0.45 8.48e-18 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.88 -0.31 9.73e-9 Extrinsic epigenetic age acceleration; LUSC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg06046430 chr4:77819534 ANKRD56 0.48 7.24 0.37 3.15e-12 Emphysema distribution in smoking; LUSC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg21211367 chr2:162094118 NA 0.44 7.13 0.36 6.31e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs9303401 0.703 rs8072182 chr17:57211213 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.47 6.92 0.35 2.39e-11 Cognitive test performance; LUSC cis rs4906332 0.966 rs12894275 chr14:103901424 A/G cg04998671 chr14:104000505 TRMT61A 0.43 6.81 0.35 4.53e-11 Coronary artery disease; LUSC cis rs1113500 0.933 rs12132785 chr1:108633083 A/T cg06207961 chr1:108661230 NA 0.4 7.45 0.38 8.18e-13 Growth-regulated protein alpha levels; LUSC cis rs11098499 0.722 rs17595727 chr4:120262074 C/T cg09307838 chr4:120376055 NA -0.61 -9.11 -0.45 7.91e-18 Corneal astigmatism; LUSC cis rs16976116 0.951 rs28706531 chr15:55477072 G/A cg11288833 chr15:55489084 RSL24D1 0.52 6.33 0.33 7.81e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -9.55 -0.46 2.85e-19 Developmental language disorder (linguistic errors); LUSC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg04756594 chr16:24857601 SLC5A11 -0.49 -7.28 -0.37 2.37e-12 Intelligence (multi-trait analysis); LUSC cis rs6733011 0.578 rs12712038 chr2:99497710 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.98 -0.36 1.57e-11 Bipolar disorder; LUSC cis rs240764 0.817 rs239247 chr6:101088350 T/C cg09795085 chr6:101329169 ASCC3 0.41 6.04 0.31 4.01e-9 Neuroticism; LUSC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg24110177 chr3:50126178 RBM5 0.56 9.15 0.45 5.78e-18 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.806 rs4074522 chr3:134325626 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.79 12.8 0.57 8.8e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9527 0.590 rs10883839 chr10:104920341 A/G cg23093090 chr10:104574429 C10orf26 -0.4 -6.53 -0.34 2.47e-10 Arsenic metabolism; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg11645453 chr3:52864694 ITIH4 0.38 7.9 0.4 4.13e-14 Bipolar disorder; LUSC cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg00990874 chr7:1149470 C7orf50 -0.61 -7.82 -0.39 6.96e-14 Bronchopulmonary dysplasia; LUSC cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg24642439 chr20:33292090 TP53INP2 -0.52 -7.78 -0.39 8.86e-14 Glomerular filtration rate (creatinine); LUSC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg09267113 chr7:98030324 BAIAP2L1 0.41 6.24 0.32 1.34e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC cis rs1670533 0.932 rs4690347 chr4:1057328 A/G cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC cis rs7119 1.000 rs7119 chr15:77777632 C/T cg27398640 chr15:77910606 LINGO1 -0.3 -7.04 -0.36 1.13e-11 Type 2 diabetes; LUSC cis rs7131987 0.621 rs57803026 chr12:29497506 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -7.13 -0.36 6.34e-12 QT interval; LUSC cis rs4664304 0.900 rs17231993 chr2:160741415 C/T cg03641300 chr2:160917029 PLA2R1 -0.38 -6.16 -0.32 2.09e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg00321850 chr1:175162397 KIAA0040 0.45 7.69 0.39 1.7e-13 Alcohol dependence; LUSC cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs9399135 0.967 rs4895436 chr6:135295001 G/A cg22676075 chr6:135203613 NA 0.47 7.33 0.37 1.72e-12 Red blood cell count; LUSC cis rs12594515 0.967 rs67854274 chr15:45990518 A/G cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.58 -5.9 -0.31 8.89e-9 Lung cancer in ever smokers; LUSC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.26 -0.32 1.22e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6696846 0.703 rs112653854 chr1:205079251 G/T cg21545522 chr1:205238299 TMCC2 0.45 8.5 0.42 6.56e-16 Red blood cell count; LUSC cis rs9611565 0.592 rs4822040 chr22:41963553 C/G cg03806693 chr22:41940476 POLR3H -0.91 -12.65 -0.57 3.07e-30 Vitiligo; LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg08470875 chr2:26401718 FAM59B -0.68 -8.9 -0.44 3.59e-17 Gut microbiome composition (summer); LUSC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.49 7.33 0.37 1.72e-12 Menarche (age at onset); LUSC cis rs9527 0.590 rs7087040 chr10:104799668 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.63 0.47 1.61e-19 Arsenic metabolism; LUSC cis rs4654899 0.758 rs2320826 chr1:21392096 A/C cg01072550 chr1:21505969 NA -0.5 -7.79 -0.39 8.58e-14 Superior frontal gyrus grey matter volume; LUSC cis rs3862435 0.572 rs2589967 chr15:90907876 T/C cg22089800 chr15:90895588 ZNF774 0.58 6.36 0.33 6.51e-10 Response to exercise (triglyceride level interaction); LUSC cis rs7805747 0.961 rs17173238 chr7:151406220 A/G cg17611936 chr7:151411526 PRKAG2 0.46 6.44 0.33 4.28e-10 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); LUSC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg08048268 chr3:133502702 NA -0.41 -7.84 -0.39 6.1e-14 Iron status biomarkers; LUSC cis rs4737010 0.501 rs990174 chr8:41632230 A/G cg17182837 chr8:41585554 ANK1 -0.36 -6.5 -0.34 2.87e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC trans rs12310956 0.515 rs115836245 chr12:33951369 T/C cg13010199 chr12:38710504 ALG10B 0.5 7.53 0.38 4.69e-13 Morning vs. evening chronotype; LUSC trans rs7829975 0.593 rs2921051 chr8:8320104 C/A cg27411982 chr8:10470053 RP1L1 0.37 5.95 0.31 6.64e-9 Mood instability; LUSC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.26 -0.37 2.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs3857536 0.566 rs208463 chr6:66913962 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.77 -10.59 -0.5 8.96e-23 Blood trace element (Cu levels); LUSC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs72792276 1.000 rs72792279 chr5:127374404 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 7.44 0.38 8.76e-13 Red cell distribution width; LUSC cis rs6089584 0.526 rs6061965 chr20:60607858 A/C cg06108461 chr20:60628389 TAF4 -0.74 -12.21 -0.56 1.33e-28 Body mass index; LUSC cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg01973587 chr1:228161476 NA 0.44 8.04 0.4 1.62e-14 Diastolic blood pressure; LUSC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg04998671 chr14:104000505 TRMT61A -0.42 -5.89 -0.31 9.64e-9 Reticulocyte count; LUSC cis rs2075671 0.903 rs62482249 chr7:100262357 C/A cg16850897 chr7:100343110 ZAN -0.57 -7.81 -0.39 7.66e-14 Other erythrocyte phenotypes; LUSC cis rs10887741 0.690 rs10509410 chr10:89440001 C/T cg13926569 chr10:89418898 PAPSS2 0.34 7.62 0.38 2.58e-13 Exercise (leisure time); LUSC cis rs4631830 0.737 rs7071471 chr10:51503335 C/T cg10326726 chr10:51549505 MSMB 0.36 6.04 0.31 4.02e-9 Prostate-specific antigen levels; LUSC trans rs17685 0.961 rs41301394 chr7:75612803 C/T cg19862616 chr7:65841803 NCRNA00174 0.87 12.74 0.57 1.38e-30 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg21782813 chr7:2030301 MAD1L1 -0.37 -6.15 -0.32 2.27e-9 Schizophrenia; LUSC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg05872129 chr22:39784769 NA -0.55 -8.97 -0.44 2.13e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg22143856 chr6:28129313 ZNF389 -0.41 -5.8 -0.3 1.55e-8 Depression; LUSC cis rs941898 0.957 rs2181102 chr14:100583949 A/G cg26002632 chr14:100625216 DEGS2 0.33 6.06 0.31 3.73e-9 White matter hyperintensity burden; LUSC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg03433033 chr1:76189801 ACADM -0.73 -10.08 -0.48 4.94e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg21963583 chr11:68658836 MRPL21 0.55 8.08 0.4 1.22e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7100689 0.646 rs6585946 chr10:82118292 G/T cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 3.98e-32 Post bronchodilator FEV1; LUSC trans rs11098499 0.954 rs3733520 chr4:120423480 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.54 0.34 2.32e-10 Corneal astigmatism; LUSC cis rs754466 0.957 rs61854183 chr10:79698077 T/C cg17075019 chr10:79541650 NA -0.64 -8.18 -0.41 5.81e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg11062466 chr8:58055876 NA 0.65 8.17 0.41 6.25e-15 Developmental language disorder (linguistic errors); LUSC cis rs672059 1.000 rs1760621 chr1:183156006 T/G ch.1.3577855R chr1:183094577 LAMC1 0.55 8.05 0.4 1.44e-14 Hypertriglyceridemia; LUSC cis rs9811920 0.683 rs793439 chr3:99637783 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.35 6.76 0.35 6.26e-11 Axial length; LUSC cis rs9921192 1.000 rs251733 chr16:4321605 A/T cg07945448 chr16:4304224 NA 0.44 6.3 0.33 9.61e-10 Prostate-specific antigen levels; LUSC cis rs2455601 0.935 rs12049908 chr11:8919309 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.88 -0.35 2.9100000000000002e-11 Schizophrenia; LUSC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg11168104 chr5:1857477 NA -0.32 -5.71 -0.3 2.44e-8 Cardiovascular disease risk factors; LUSC cis rs3770081 0.590 rs12622715 chr2:86453563 G/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.07 -7.19 -0.37 4.25e-12 Facial emotion recognition (sad faces); LUSC cis rs9987353 0.519 rs2929465 chr8:9064002 C/G cg06636001 chr8:8085503 FLJ10661 -0.4 -5.75 -0.3 2.03e-8 Recombination measurement; LUSC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.36e-10 Extrinsic epigenetic age acceleration; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg21782813 chr7:2030301 MAD1L1 0.4 6.58 0.34 1.82e-10 Bipolar disorder and schizophrenia; LUSC cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg16322792 chr1:120165303 ZNF697 -0.73 -15.2 -0.64 4.89e-40 Systemic lupus erythematosus; LUSC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg18512352 chr11:47633146 NA -0.48 -9.57 -0.46 2.41e-19 Subjective well-being; LUSC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg14784868 chr12:69753453 YEATS4 0.61 8.75 0.43 1.07e-16 Blood protein levels; LUSC cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg24812749 chr6:127587940 RNF146 0.89 13.12 0.58 5.18e-32 Breast cancer; LUSC cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg23158103 chr7:148848205 ZNF398 -0.47 -7.71 -0.39 1.5e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7098414 0.511 rs7071752 chr10:82159539 C/A cg00277334 chr10:82204260 NA -0.61 -10.01 -0.48 8.38e-21 Post bronchodilator FEV1; LUSC cis rs5769707 0.667 rs4824069 chr22:50030325 T/C cg20744362 chr22:50050164 C22orf34 0.39 7.31 0.37 1.98e-12 Monocyte count;Monocyte percentage of white cells; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg16016176 chr3:119298513 ADPRH 0.39 5.97 0.31 5.96e-9 Educational attainment (years of education); LUSC cis rs6998277 0.830 rs6468836 chr8:103602630 A/G cg10187029 chr8:103597600 NA 0.8 12.41 0.56 2.47e-29 Migraine; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11788103 chr19:12833533 TNPO2 0.49 7.52 0.38 5.21e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6582630 0.599 rs11181807 chr12:38403763 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.7 -0.34 8.84e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs4363385 0.818 rs574649 chr1:153008471 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs9325144 0.555 rs7960411 chr12:38703019 A/G cg26384229 chr12:38710491 ALG10B -0.63 -9.78 -0.47 4.8e-20 Morning vs. evening chronotype; LUSC cis rs4948102 1.000 rs4948102 chr7:56097265 C/G cg17215666 chr7:56131930 SUMF2 0.45 5.77 0.3 1.8e-8 Plasma homocysteine levels (post-methionine load test); LUSC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.7 -0.34 8.85e-11 Menopause (age at onset); LUSC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.47e-8 Extrinsic epigenetic age acceleration; LUSC cis rs72781680 0.848 rs715646 chr2:24010566 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs9329221 0.506 rs6993610 chr8:10330994 C/G cg21775007 chr8:11205619 TDH -0.43 -5.9 -0.31 9.14e-9 Neuroticism; LUSC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs9399401 0.961 rs7774095 chr6:142670862 C/A cg03128060 chr6:142623767 GPR126 0.31 5.69 0.3 2.8e-8 Chronic obstructive pulmonary disease; LUSC cis rs798766 1.000 rs798766 chr4:1734239 C/T cg10756475 chr4:1757242 NA -0.38 -6.02 -0.31 4.57e-9 Bladder cancer;Urinary bladder cancer; LUSC cis rs11579220 1 rs11579220 chr1:205144363 G/T cg21643547 chr1:205240462 TMCC2 -0.43 -7.8 -0.39 8.02e-14 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs500891 0.525 rs3757011 chr6:84081069 G/C cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC trans rs11743006 0.626 rs56066735 chr5:136506397 T/C cg07379741 chr17:7311030 NLGN2 0.41 6.11 0.32 2.82e-9 Mathematical ability; LUSC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg10792982 chr14:105748885 BRF1 0.52 9.5 0.46 4.24e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs4253772 0.872 rs45552534 chr22:46638171 G/A cg09491104 chr22:46646882 C22orf40 -0.59 -6.48 -0.33 3.23e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9916302 0.706 rs11657153 chr17:37699729 A/G cg07936489 chr17:37558343 FBXL20 -0.83 -10.29 -0.49 9.28e-22 Glomerular filtration rate (creatinine); LUSC cis rs554111 0.656 rs17450586 chr1:21254593 T/G cg01072550 chr1:21505969 NA 0.4 6.1 0.32 3e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs2463822 0.844 rs1919359 chr11:62055703 A/G cg06239285 chr11:62104954 ASRGL1 0.91 8.38 0.42 1.45e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7824557 0.707 rs3808518 chr8:11143272 A/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.57e-10 Retinal vascular caliber; LUSC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg09877947 chr5:131593287 PDLIM4 0.43 7.1 0.36 7.66e-12 Blood metabolite levels; LUSC trans rs853679 0.607 rs68188794 chr6:28080777 T/C cg01620082 chr3:125678407 NA -0.85 -7.28 -0.37 2.42e-12 Depression; LUSC cis rs4843185 0.576 rs381624 chr16:85728679 G/A cg05245094 chr16:85669572 KIAA0182 0.41 6.11 0.32 2.73e-9 Platelet distribution width; LUSC cis rs12980942 0.591 rs11879435 chr19:41757603 C/T cg25627403 chr19:41769009 HNRNPUL1 0.71 7.41 0.38 1.03e-12 Coronary artery disease; LUSC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg19318889 chr4:1322082 MAEA 0.52 8.83 0.44 5.95e-17 Longevity; LUSC cis rs9329221 0.623 rs7825778 chr8:10261010 C/T cg21775007 chr8:11205619 TDH -0.5 -6.92 -0.35 2.38e-11 Neuroticism; LUSC cis rs1775715 0.737 rs2799012 chr10:32103077 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.68e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs887829 0.588 rs6715325 chr2:234635241 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.86 -0.4 5.4e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs1865721 0.682 rs3745081 chr18:73142923 A/G cg26385618 chr18:73139727 C18orf62 -0.47 -8.83 -0.44 5.92e-17 Intelligence; LUSC cis rs12422267 0.609 rs10128884 chr12:132621624 C/T cg09764611 chr12:132620959 NA -0.58 -9.21 -0.45 3.71e-18 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg14159672 chr1:205819179 PM20D1 0.86 15.35 0.64 1.34e-40 Menarche (age at onset); LUSC trans rs72674100 1.000 rs28461859 chr4:97988033 T/A cg09670535 chr1:18959427 PAX7 -0.56 -6.01 -0.31 4.76e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.31 -0.33 8.8e-10 Lung cancer; LUSC cis rs9796 0.870 rs2925346 chr15:41315695 G/A cg18705301 chr15:41695430 NDUFAF1 0.45 7.84 0.39 5.94e-14 Menopause (age at onset); LUSC cis rs300703 0.515 rs300694 chr2:182277 G/T cg21211680 chr2:198530 NA -0.54 -6.69 -0.34 9.29e-11 Blood protein levels; LUSC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.41 -7.64 -0.39 2.29e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs240768 1.000 rs240785 chr6:100973377 C/T cg12253828 chr6:101329408 ASCC3 -0.82 -5.82 -0.3 1.4e-8 Economic and political preferences (immigration/crime); LUSC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg07424592 chr7:64974309 NA 0.7 6.07 0.32 3.39e-9 Diabetic kidney disease; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.59 0.38 3.29e-13 Prudent dietary pattern; LUSC cis rs796364 0.625 rs1369843 chr2:201088171 A/G cg23649088 chr2:200775458 C2orf69 0.6 8.03 0.4 1.67e-14 Schizophrenia; LUSC cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.48 -9.07 -0.44 1.08e-17 Axial length; LUSC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg03452623 chr4:187889614 NA -0.86 -17.47 -0.69 5.36e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg18681998 chr4:17616180 MED28 0.78 13.54 0.6 1.34e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg13319975 chr6:146136371 FBXO30 0.48 7.25 0.37 2.88e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7131987 0.650 rs6487808 chr12:29463359 C/T cg09582351 chr12:29534625 ERGIC2 0.35 7.04 0.36 1.07e-11 QT interval; LUSC cis rs10992471 0.580 rs10992304 chr9:95085365 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.49 -7.87 -0.4 5.08e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.44 -0.33 4.14e-10 Total body bone mineral density; LUSC cis rs1113500 0.548 rs3853497 chr1:108657184 C/T cg06207961 chr1:108661230 NA 0.38 6.27 0.32 1.12e-9 Growth-regulated protein alpha levels; LUSC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg21545522 chr1:205238299 TMCC2 0.49 9.16 0.45 5.45e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs66887589 0.592 rs28580295 chr4:120278873 C/T cg13609457 chr4:120235615 NA 0.38 5.77 0.3 1.81e-8 Diastolic blood pressure; LUSC cis rs4727027 0.870 rs13237714 chr7:148884083 A/G cg23158103 chr7:148848205 ZNF398 -0.49 -7.99 -0.4 2.27e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.28 0.32 1.08e-9 Tonsillectomy; LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 12.26 0.56 8.48e-29 Alzheimer's disease; LUSC trans rs2055729 0.813 rs55999429 chr8:9741185 G/C cg06636001 chr8:8085503 FLJ10661 -0.5 -6.72 -0.35 7.95e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs1691799 0.899 rs1183272 chr12:66735421 T/C cg16791601 chr12:66731901 HELB -0.72 -12.58 -0.57 5.73e-30 White blood cell count (basophil); LUSC trans rs7824557 0.564 rs2572379 chr8:11237480 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.5 -0.34 2.9e-10 Retinal vascular caliber; LUSC cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg26647111 chr11:31128758 NA 0.43 6.16 0.32 2.13e-9 Red blood cell count; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg24739457 chr1:205821442 NA 0.41 7.25 0.37 2.89e-12 Menarche (age at onset); LUSC cis rs614226 0.935 rs2235222 chr12:120892193 G/C cg27489772 chr12:121021490 NA -0.61 -7.84 -0.39 6.05e-14 Type 1 diabetes nephropathy; LUSC trans rs61931739 0.517 rs7139189 chr12:34319757 T/C cg26384229 chr12:38710491 ALG10B 0.65 10.52 0.5 1.55e-22 Morning vs. evening chronotype; LUSC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.1 -0.41 1.02e-14 Personality dimensions; LUSC cis rs8180040 1.000 rs807810 chr3:47403892 G/A cg16586182 chr3:47516702 SCAP 0.49 7.62 0.38 2.7e-13 Colorectal cancer; LUSC cis rs7674212 0.581 rs11946020 chr4:103944742 T/C cg16532752 chr4:104119610 CENPE -0.45 -6.23 -0.32 1.42e-9 Type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06157335 chr1:53164003 C1orf163 0.47 6.78 0.35 5.37e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.02 -0.44 1.5e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg16606324 chr3:10149918 C3orf24 0.58 8.23 0.41 4.27e-15 Alzheimer's disease; LUSC cis rs7178375 0.607 rs7171212 chr15:31207711 C/T cg01738805 chr15:31195741 MTMR15 0.86 7.05 0.36 1.03e-11 Hypertriglyceridemia; LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.84 0.39 5.94e-14 Prudent dietary pattern; LUSC cis rs1904096 0.506 rs7697827 chr4:95184748 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.16 -0.41 6.72e-15 Type 2 diabetes; LUSC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.05e-8 Reticulocyte fraction of red cells; LUSC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC trans rs11992162 0.636 rs4841644 chr8:11798433 A/C cg27411982 chr8:10470053 RP1L1 0.42 6.25 0.32 1.25e-9 Monocyte count; LUSC cis rs9309473 1.000 rs7583255 chr2:73797996 T/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.48 -0.33 3.37e-10 Metabolite levels; LUSC trans rs10435719 0.902 rs7459983 chr8:11807221 T/C cg08975724 chr8:8085496 FLJ10661 0.48 6.9 0.35 2.55e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg21433313 chr16:3507492 NAT15 -0.7 -8.81 -0.43 6.94e-17 Tuberculosis; LUSC cis rs9807989 0.507 rs2287033 chr2:103011237 C/T cg03938978 chr2:103052716 IL18RAP -0.35 -6.55 -0.34 2.19e-10 Asthma; LUSC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg14773178 chr5:1868261 NA 0.36 6.69 0.34 9.65e-11 Cardiovascular disease risk factors; LUSC cis rs3087591 0.683 rs2525567 chr17:29675673 C/A cg24425628 chr17:29625626 OMG;NF1 0.47 7.0 0.36 1.44e-11 Hip circumference; LUSC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg25251562 chr2:3704773 ALLC -0.49 -7.44 -0.38 8.43e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2073300 0.609 rs6137915 chr20:23358509 A/G cg12062639 chr20:23401060 NAPB -0.87 -7.7 -0.39 1.58e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg13531842 chr10:38383804 ZNF37A 0.49 7.52 0.38 5.08e-13 Extrinsic epigenetic age acceleration; LUSC cis rs9650315 0.866 rs35152040 chr8:57201462 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.31 0.37 1.93e-12 Height; LUSC cis rs4363385 0.818 rs2879487 chr1:152985360 C/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.38 -0.37 1.25e-12 Inflammatory skin disease; LUSC trans rs8072100 0.967 rs11871606 chr17:45732774 G/T cg04995722 chr7:26192034 NFE2L3 0.38 6.32 0.33 8.6e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs61931739 0.534 rs7302688 chr12:34235064 A/G cg26384229 chr12:38710491 ALG10B 0.73 11.94 0.55 1.27e-27 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18604876 chr3:5164258 ARL8B -0.52 -6.7 -0.34 9.04e-11 Bipolar disorder and schizophrenia; LUSC cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg04450456 chr4:17643702 FAM184B 0.4 6.73 0.35 7.5e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs59698941 0.943 rs66500331 chr5:132261693 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg16393715 chr7:1948819 MAD1L1 0.36 6.2 0.32 1.63e-9 Bipolar disorder and schizophrenia; LUSC trans rs11992162 0.933 rs10108075 chr8:11832079 A/G cg15556689 chr8:8085844 FLJ10661 0.57 8.3 0.41 2.64e-15 Monocyte count; LUSC cis rs9479482 0.967 rs1543547 chr6:150346532 T/C cg07578070 chr6:150326732 RAET1K 0.39 6.1 0.32 2.89e-9 Alopecia areata; LUSC cis rs9326248 0.861 rs7120309 chr11:117042816 T/A cg26566898 chr11:117069891 TAGLN 0.39 6.28 0.32 1.08e-9 Blood protein levels; LUSC cis rs6089584 0.830 rs6089309 chr20:60585687 T/C cg24733560 chr20:60626293 TAF4 0.37 5.98 0.31 5.71e-9 Body mass index; LUSC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg15448220 chr1:150897856 SETDB1 0.42 6.11 0.32 2.75e-9 Melanoma; LUSC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg25204440 chr1:209979598 IRF6 0.53 6.98 0.36 1.6e-11 Cleft lip with or without cleft palate; LUSC cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.4 0.53 1.17e-25 Colorectal cancer; LUSC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11122272 0.735 rs2749711 chr1:231537543 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.91 -0.48 1.78e-20 Hemoglobin concentration; LUSC cis rs909002 0.962 rs7537646 chr1:32135495 G/A cg01639898 chr1:32083012 HCRTR1 0.26 5.94 0.31 7.1e-9 Intelligence (multi-trait analysis); LUSC cis rs11105298 0.891 rs11105287 chr12:89829470 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.5 -7.0 -0.36 1.4e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11250098 0.574 rs4554431 chr8:10771638 T/A cg27411982 chr8:10470053 RP1L1 -0.46 -6.82 -0.35 4.29e-11 Morning vs. evening chronotype; LUSC cis rs4820539 0.966 rs2301554 chr22:23484254 A/C cg21100191 chr22:23484243 RTDR1 0.93 16.43 0.67 7.13e-45 Bone mineral density; LUSC cis rs11630290 0.592 rs1039817 chr15:64155367 T/A cg12036633 chr15:63758958 NA 0.52 6.63 0.34 1.37e-10 Iris characteristics; LUSC cis rs6750795 0.518 rs1434519 chr2:232433761 A/G cg19187155 chr2:232395269 NMUR1 0.76 11.16 0.52 8.85e-25 Height; LUSC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4356932 0.967 rs28505472 chr4:76972727 C/T cg00809888 chr4:76862425 NAAA 0.34 5.78 0.3 1.75e-8 Blood protein levels; LUSC cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg20607798 chr8:58055168 NA 0.57 5.78 0.3 1.7e-8 Developmental language disorder (linguistic errors); LUSC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7589342 0.929 rs7590652 chr2:106440306 A/G cg14210321 chr2:106509881 NCK2 -0.55 -8.42 -0.42 1.15e-15 Addiction; LUSC cis rs897984 0.568 rs67264578 chr16:30879395 G/A cg02466173 chr16:30829666 NA -0.53 -8.61 -0.43 2.84e-16 Dementia with Lewy bodies; LUSC trans rs62458065 0.513 rs10265319 chr7:32571564 A/C cg00845942 chr12:64062724 DPY19L2 -0.62 -7.84 -0.39 6.14e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9534288 0.830 rs1126364 chr13:46633394 C/G cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC cis rs6701037 1.000 rs11585617 chr1:175123186 C/G cg00321850 chr1:175162397 KIAA0040 -0.43 -7.3 -0.37 2.06e-12 Alcohol dependence; LUSC cis rs2404602 0.647 rs12913024 chr15:77145216 C/T cg23625390 chr15:77176239 SCAPER -0.66 -9.95 -0.48 1.38e-20 Blood metabolite levels; LUSC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg17279839 chr7:150038598 RARRES2 0.48 7.6 0.38 3.05e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg15212455 chr7:39170539 POU6F2 0.62 9.89 0.48 2.15e-20 IgG glycosylation; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19223106 chr19:58898630 RPS5 0.49 7.91 0.4 3.83e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4566357 0.930 rs6436647 chr2:227922958 G/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg08045932 chr20:61659980 NA 0.59 10.57 0.5 1.05e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.05 0.48 6.03e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9814567 0.928 rs6768323 chr3:134268737 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg07211511 chr3:129823064 LOC729375 -1.24 -20.03 -0.74 3.4e-59 Blood pressure (smoking interaction); LUSC cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs4843185 0.669 rs4843506 chr16:85715440 T/A cg00168118 chr16:85669675 KIAA0182 0.37 5.73 0.3 2.25e-8 Platelet distribution width; LUSC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.85 0.75 2.06e-62 Homoarginine levels; LUSC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg00431813 chr7:1051703 C7orf50 -0.38 -6.11 -0.32 2.73e-9 Longevity;Endometriosis; LUSC cis rs8013055 0.846 rs12893999 chr14:105970842 C/G cg19700328 chr14:106028568 NA -0.41 -6.88 -0.35 2.95e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg24578937 chr1:2090814 PRKCZ -0.41 -8.94 -0.44 2.65e-17 Height; LUSC cis rs6964587 1.000 rs9969198 chr7:91567492 G/T cg01689657 chr7:91764605 CYP51A1 -0.32 -5.86 -0.31 1.14e-8 Breast cancer; LUSC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg08027265 chr7:2291960 NA -0.39 -6.45 -0.33 3.88e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6840360 0.642 rs2034061 chr4:152420756 C/T cg20465933 chr4:152376761 FAM160A1 0.32 5.69 0.3 2.8e-8 Intelligence (multi-trait analysis); LUSC cis rs9790314 1.000 rs189270 chr3:161063504 T/C cg04691961 chr3:161091175 C3orf57 -0.35 -6.05 -0.31 3.9e-9 Morning vs. evening chronotype; LUSC cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg23791538 chr6:167370224 RNASET2 0.37 6.03 0.31 4.43e-9 Crohn's disease; LUSC cis rs7944584 0.511 rs10838731 chr11:47607135 C/T cg20307385 chr11:47447363 PSMC3 0.87 13.96 0.61 3.36e-35 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1348850 0.872 rs7559521 chr2:178452328 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.47 -6.08 -0.32 3.25e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs16848425 1.000 rs28608630 chr4:73526279 A/G cg15289899 chr11:2397255 CD81 0.68 5.96 0.31 6.35e-9 Height; LUSC trans rs6502050 0.805 rs62078303 chr17:80085210 A/G cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs1372520 0.684 rs2737010 chr4:90746466 G/A cg01966878 chr4:90757139 SNCA -0.43 -6.16 -0.32 2.13e-9 Neuroticism; LUSC cis rs9325144 0.560 rs11182952 chr12:38636278 C/A cg13010199 chr12:38710504 ALG10B -0.51 -7.71 -0.39 1.45e-13 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08327705 chr5:6756273 POLS 0.45 6.54 0.34 2.31e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs1568889 0.877 rs1384903 chr11:28124359 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.58 6.94 0.35 2.06e-11 Bipolar disorder; LUSC cis rs11608355 0.576 rs1477117 chr12:109888779 A/G cg05360138 chr12:110035743 NA -0.87 -10.68 -0.5 4.11e-23 Neuroticism; LUSC cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg01256987 chr12:42539512 GXYLT1 -0.46 -8.71 -0.43 1.46e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg04267008 chr7:1944627 MAD1L1 -0.45 -6.61 -0.34 1.53e-10 Schizophrenia; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg07157834 chr1:205819609 PM20D1 0.85 15.31 0.64 1.86e-40 Menarche (age at onset); LUSC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg03060546 chr3:49711283 APEH 0.67 7.7 0.39 1.51e-13 Menarche (age at onset); LUSC cis rs372883 0.506 rs2832301 chr21:30749712 G/A cg08807101 chr21:30365312 RNF160 0.62 9.93 0.48 1.59e-20 Pancreatic cancer; LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg26695010 chr11:65641043 EFEMP2 -0.47 -7.08 -0.36 8.68e-12 Eosinophil percentage of white cells; LUSC cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg06784218 chr1:46089804 CCDC17 0.55 11.17 0.52 7.91e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg18827107 chr12:86230957 RASSF9 0.47 7.07 0.36 9.01e-12 Major depressive disorder; LUSC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg22920501 chr2:26401640 FAM59B -0.74 -10.85 -0.51 1.06e-23 Gut microbiome composition (summer); LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg15147215 chr3:52552868 STAB1 -0.33 -6.37 -0.33 6.24e-10 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.875 rs1788178 chr8:101332518 A/C cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs4654899 0.931 rs4654880 chr1:21186608 C/A cg01072550 chr1:21505969 NA 0.48 7.28 0.37 2.41e-12 Superior frontal gyrus grey matter volume; LUSC cis rs4737010 0.570 rs6474364 chr8:41646997 T/G cg17182837 chr8:41585554 ANK1 -0.36 -6.41 -0.33 4.92e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs4629710 0.592 rs1885641 chr6:131553986 A/G cg12606694 chr6:131520996 AKAP7 0.62 9.42 0.46 7.5e-19 Multiple myeloma (IgH translocation); LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg00814883 chr7:100076585 TSC22D4 -0.76 -10.49 -0.5 1.99e-22 Platelet count; LUSC cis rs7107174 0.579 rs10793299 chr11:78018954 T/A cg02023728 chr11:77925099 USP35 0.48 6.76 0.35 6.33e-11 Testicular germ cell tumor; LUSC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg12310025 chr6:25882481 NA -0.56 -9.57 -0.46 2.5e-19 Intelligence (multi-trait analysis); LUSC cis rs12545109 0.800 rs2576599 chr8:57388410 G/A cg09654669 chr8:57350985 NA -0.51 -6.95 -0.36 1.98e-11 Obesity-related traits; LUSC cis rs9473147 0.516 rs2151975 chr6:47515663 T/C cg12968598 chr6:47444699 CD2AP 0.52 7.94 0.4 3.18e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs10465746 0.780 rs10874424 chr1:84424033 C/T cg10977910 chr1:84465055 TTLL7 0.44 6.34 0.33 7.39e-10 Obesity-related traits; LUSC trans rs853679 0.607 rs67040724 chr6:27905509 T/C cg06606381 chr12:133084897 FBRSL1 -0.97 -8.52 -0.42 5.67e-16 Depression; LUSC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.66 0.34 1.13e-10 Breast cancer; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg19318889 chr4:1322082 MAEA 0.43 6.98 0.36 1.58e-11 Obesity-related traits; LUSC cis rs7617480 0.648 rs9859473 chr3:48837182 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.91 0.48 1.8899999999999998e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg22433210 chr17:43662623 NA -0.72 -10.4 -0.49 4.03e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg05283184 chr6:79620031 NA -0.55 -11.23 -0.52 4.78e-25 Intelligence (multi-trait analysis); LUSC cis rs11030122 0.702 rs7102215 chr11:3943970 C/T cg18678763 chr11:4115507 RRM1 -0.45 -5.75 -0.3 2.06e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.34 -5.96 -0.31 6.45e-9 Hematocrit; LUSC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.0 0.52 3.23e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg05754148 chr16:3507555 NAT15 -0.48 -6.94 -0.36 2.01e-11 Tuberculosis; LUSC cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg23583168 chr7:148888333 NA -0.85 -14.8 -0.63 1.92e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg23978390 chr7:1156363 C7orf50 0.47 6.62 0.34 1.44e-10 Longevity;Endometriosis; LUSC trans rs208520 0.955 rs28684412 chr6:66979430 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg11062466 chr8:58055876 NA 0.65 8.48 0.42 7.17e-16 Developmental language disorder (linguistic errors); LUSC cis rs2274273 0.624 rs7150234 chr14:55802181 A/G cg04306507 chr14:55594613 LGALS3 0.47 9.31 0.45 1.79e-18 Protein biomarker; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.4 0.53 1.2e-25 Menopause (age at onset); LUSC trans rs17039065 1.000 rs72889379 chr4:109390266 C/T cg07444054 chr2:108107501 NA 0.42 6.17 0.32 1.93e-9 Gut microbiome composition (summer); LUSC cis rs1728785 1.000 rs1728765 chr16:68589433 G/A cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.4e-10 Ulcerative colitis; LUSC cis rs12541635 0.934 rs2115703 chr8:107045935 C/G cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.72e-20 Age of smoking initiation; LUSC cis rs2282300 0.739 rs6484478 chr11:30306440 A/G cg25418670 chr11:30344373 C11orf46 0.64 9.15 0.45 5.83e-18 Morning vs. evening chronotype; LUSC cis rs4423214 1.000 rs4944956 chr11:71167765 C/T cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.38e-24 Vitamin D levels; LUSC cis rs68170813 0.652 rs17482494 chr7:107168487 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs1395 1.000 rs1275522 chr2:27426878 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.39 -6.47 -0.33 3.47e-10 Blood metabolite levels; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg21724239 chr8:58056113 NA 0.78 9.27 0.45 2.34e-18 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs28539607 chr4:97977256 T/G cg09670535 chr1:18959427 PAX7 -0.56 -5.98 -0.31 5.64e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9393777 0.623 rs16891717 chr6:26477143 T/A cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.933 rs2103971 chr20:33786256 T/C cg24642439 chr20:33292090 TP53INP2 -0.42 -6.04 -0.31 4.17e-9 Height; LUSC cis rs16949788 1.000 rs9672789 chr15:66713633 C/A cg08120210 chr15:66682733 MAP2K1 -0.59 -5.95 -0.31 6.69e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.16 0.32 2.06e-9 Systolic blood pressure; LUSC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg24829409 chr8:58192753 C8orf71 -0.56 -5.92 -0.31 7.93e-9 Developmental language disorder (linguistic errors); LUSC cis rs68170813 0.559 rs12536485 chr7:106978005 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.66 -0.3 3.35e-8 Coronary artery disease; LUSC cis rs9987353 0.620 rs34455383 chr8:9066458 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.27 -0.32 1.11e-9 Recombination measurement; LUSC cis rs11711311 1.000 rs2603792 chr3:113509187 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.93 0.35 2.19e-11 IgG glycosylation; LUSC cis rs12618769 0.543 rs3769728 chr2:99103001 G/A cg10123293 chr2:99228465 UNC50 0.46 7.64 0.39 2.35e-13 Bipolar disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04511966 chr5:180618506 NA 0.47 6.35 0.33 7.11e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11748023 0.605 rs249616 chr5:139529656 C/T cg26211634 chr5:139558579 C5orf32 0.31 5.68 0.3 2.96e-8 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.747 rs4709379 chr6:160227530 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.61 7.48 0.38 6.47e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7647973 0.710 rs9869120 chr3:49624065 T/C cg03060546 chr3:49711283 APEH 0.65 6.99 0.36 1.46e-11 Menarche (age at onset); LUSC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.91 15.06 0.64 1.82e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8017423 0.967 rs11621045 chr14:90714003 C/T cg04374321 chr14:90722782 PSMC1 0.74 11.76 0.54 5.76e-27 Mortality in heart failure; LUSC cis rs11098499 0.865 rs28753180 chr4:120405367 A/T cg24375607 chr4:120327624 NA 0.79 11.91 0.55 1.72e-27 Corneal astigmatism; LUSC cis rs2285947 0.901 rs2285943 chr7:21582963 G/T cg04471919 chr7:21584483 DNAH11 0.35 7.75 0.39 1.1e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC cis rs7197653 0.748 rs58542611 chr16:68350219 C/T cg05110241 chr16:68378359 PRMT7 -0.82 -8.9 -0.44 3.6e-17 Magnesium levels; LUSC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg01097406 chr16:89675127 NA -0.35 -7.1 -0.36 7.44e-12 Vitiligo; LUSC cis rs561341 0.710 rs9900031 chr17:30199537 T/C cg13647721 chr17:30228624 UTP6 -0.67 -6.12 -0.32 2.58e-9 Hip circumference adjusted for BMI; LUSC cis rs12122100 0.837 rs12142004 chr1:146506676 T/C cg03526459 chr1:146549940 NA -0.41 -6.69 -0.34 9.32e-11 HIV-1 control; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26335459 chr4:2845453 ADD1 0.48 6.69 0.34 9.29e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg17063962 chr7:91808500 NA -0.58 -9.18 -0.45 4.67e-18 Breast cancer; LUSC cis rs6964587 1.000 rs12533199 chr7:91757393 C/T cg01689657 chr7:91764605 CYP51A1 0.34 6.1 0.32 2.9e-9 Breast cancer; LUSC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg19230755 chr7:65878503 NA -0.43 -6.02 -0.31 4.48e-9 Aortic root size; LUSC cis rs7572644 0.766 rs11127132 chr2:28236120 C/T cg27432699 chr2:27873401 GPN1 0.53 6.46 0.33 3.79e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg13485126 chr2:43173341 NA 0.56 6.17 0.32 1.92e-9 Schizophrenia; LUSC cis rs9875589 0.509 rs2733556 chr3:14100172 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 6.99 0.36 1.5e-11 Ovarian reserve; LUSC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg18252515 chr7:66147081 NA -1.23 -13.28 -0.59 1.37e-32 Diabetic kidney disease; LUSC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg18352616 chr4:3374830 RGS12 0.28 5.79 0.3 1.59e-8 Parental longevity (mother's age at death); LUSC cis rs11105298 0.891 rs10506972 chr12:89861529 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.22 -0.37 3.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs76878669 0.561 rs1892940 chr11:66111251 A/G cg18002602 chr11:66138449 SLC29A2 -0.47 -8.49 -0.42 6.83e-16 Educational attainment (years of education); LUSC cis rs7945718 0.875 rs9888181 chr11:12782781 G/A cg25843174 chr11:12811716 TEAD1 0.32 7.23 0.37 3.39e-12 Educational attainment (years of education); LUSC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.27 0.56 7.72e-29 Cognitive test performance; LUSC cis rs7786877 0.521 rs4729606 chr7:100321790 T/C cg20848291 chr7:100343083 ZAN -0.62 -8.51 -0.42 5.96e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg19318889 chr4:1322082 MAEA 0.46 7.52 0.38 5.18e-13 Obesity-related traits; LUSC cis rs2224391 0.628 rs2753233 chr6:5250982 T/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.59 -0.34 1.75e-10 Height; LUSC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg15704280 chr7:45808275 SEPT13 -1.01 -17.26 -0.69 3.51e-48 Coronary artery disease; LUSC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg24531977 chr5:56204891 C5orf35 -0.55 -8.18 -0.41 6.19e-15 Coronary artery disease; LUSC trans rs1005277 0.579 rs1780122 chr10:38529509 C/A cg17830980 chr10:43048298 ZNF37B -0.57 -9.2 -0.45 3.96e-18 Extrinsic epigenetic age acceleration; LUSC cis rs929354 0.772 rs6967764 chr7:156994964 C/T cg17757837 chr7:157058334 UBE3C 0.83 13.32 0.59 9.66e-33 Body mass index; LUSC cis rs7267979 0.844 rs35735333 chr20:25337205 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.8 -17.01 -0.68 3.69e-47 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs9463078 0.587 rs1150806 chr6:44897787 C/T cg25276700 chr6:44698697 NA -0.28 -5.78 -0.3 1.76e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4820539 0.641 rs5759602 chr22:23489362 C/T cg14186256 chr22:23484241 RTDR1 -0.72 -11.16 -0.52 8.31e-25 Bone mineral density; LUSC cis rs9325144 0.505 rs1906262 chr12:38653605 A/G cg13010199 chr12:38710504 ALG10B 0.6 9.27 0.45 2.42e-18 Morning vs. evening chronotype; LUSC cis rs17401966 0.540 rs6682868 chr1:10454773 C/T cg17425144 chr1:10567563 PEX14 0.35 6.16 0.32 2.11e-9 Hepatocellular carcinoma; LUSC cis rs11785693 0.862 rs73189843 chr8:5000915 C/T cg26367366 chr8:4980734 NA 0.77 8.84 0.44 5.8e-17 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg07424592 chr7:64974309 NA 0.69 6.18 0.32 1.88e-9 Diabetic kidney disease; LUSC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.07 0.32 3.45e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7572644 0.766 rs4666028 chr2:28088580 T/A cg27432699 chr2:27873401 GPN1 0.51 6.42 0.33 4.57e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs7615952 0.932 rs13325495 chr3:125637416 T/G cg07211511 chr3:129823064 LOC729375 -1.23 -18.9 -0.72 1.08e-54 Blood pressure (smoking interaction); LUSC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg24324837 chr19:49891574 CCDC155 0.49 6.92 0.35 2.31e-11 Multiple sclerosis; LUSC trans rs561341 1.000 rs56903735 chr17:30254393 T/A cg20587970 chr11:113659929 NA -1.15 -15.6 -0.65 1.32e-41 Hip circumference adjusted for BMI; LUSC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg24675658 chr1:53192096 ZYG11B 0.72 11.93 0.55 1.46e-27 Monocyte count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10367011 chr12:132434599 EP400 -0.52 -6.06 -0.31 3.57e-9 Bipolar disorder and schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12872889 chr17:74137522 FOXJ1 -0.42 -6.1 -0.32 2.87e-9 Electrocardiographic conduction measures; LUSC cis rs2377585 0.524 rs10505736 chr12:8841834 T/C cg03761649 chr12:8850719 RIMKLB 0.49 6.4 0.33 5.36e-10 Reticulocyte fraction of red cells; LUSC cis rs1371867 0.875 rs1125706 chr8:101326739 T/A cg06636551 chr8:101224915 SPAG1 -0.45 -8.17 -0.41 6.22e-15 Atrioventricular conduction; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg08736216 chr1:53307985 ZYG11A -0.28 -5.82 -0.3 1.38e-8 Monocyte count; LUSC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg06028605 chr16:24865363 SLC5A11 0.65 10.29 0.49 9.3e-22 Intelligence (multi-trait analysis); LUSC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg12365402 chr11:9010492 NRIP3 0.48 8.94 0.44 2.77e-17 Hemoglobin concentration; LUSC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg08677398 chr8:58056175 NA 0.54 6.65 0.34 1.23e-10 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.22e-14 Major depressive disorder; LUSC cis rs6964587 0.839 rs6949881 chr7:91433827 C/T cg17063962 chr7:91808500 NA 0.57 8.76 0.43 9.88e-17 Breast cancer; LUSC trans rs11098499 0.955 rs56386062 chr4:120155135 T/C cg25214090 chr10:38739885 LOC399744 0.45 6.6 0.34 1.61e-10 Corneal astigmatism; LUSC cis rs950169 0.960 rs12905475 chr15:84800495 G/A cg17173187 chr15:85201210 NMB 0.39 6.85 0.35 3.6e-11 Schizophrenia; LUSC cis rs3760982 0.565 rs3786956 chr19:44286829 C/T cg11993925 chr19:44307056 LYPD5 0.45 9.98 0.48 1.06e-20 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs57590327 0.503 rs9874184 chr3:81505439 C/T cg07356753 chr3:81810745 GBE1 0.46 6.07 0.32 3.47e-9 Extraversion; LUSC trans rs1934953 0.556 rs7909236 chr10:96829430 A/C cg08498836 chr3:149292366 WWTR1 -0.35 -6.18 -0.32 1.89e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg23711669 chr6:146136114 FBXO30 -0.83 -14.82 -0.63 1.54e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs929354 1.000 rs1182410 chr7:157063837 C/T cg05182265 chr7:156933206 UBE3C 0.48 7.25 0.37 2.99e-12 Body mass index; LUSC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg14552801 chr7:65878734 NA -0.38 -5.68 -0.3 2.92e-8 Aortic root size; LUSC cis rs3806843 0.576 rs246043 chr5:140330924 G/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg24829409 chr8:58192753 C8orf71 -0.48 -5.72 -0.3 2.42e-8 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg11663144 chr21:46675770 NA -0.41 -7.03 -0.36 1.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3733585 0.604 rs73215003 chr4:10126317 C/G cg26043149 chr18:55253948 FECH -0.52 -7.53 -0.38 4.73e-13 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs6502050 0.731 rs35156322 chr17:80096323 T/C cg07393940 chr7:158741817 NA 0.37 6.78 0.35 5.58e-11 Life satisfaction; LUSC trans rs6502050 0.731 rs34796376 chr17:80116635 G/T cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.41e-10 Life satisfaction; LUSC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.81 0.35 4.45e-11 Lung cancer; LUSC cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg26384229 chr12:38710491 ALG10B -0.81 -13.99 -0.61 2.61e-35 Bladder cancer; LUSC cis rs9467773 1.000 rs6932156 chr6:26571506 T/G cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.47e-42 Intelligence (multi-trait analysis); LUSC cis rs6547741 0.935 rs2384626 chr2:27773648 A/G cg27432699 chr2:27873401 GPN1 0.82 15.29 0.64 2.21e-40 Oral cavity cancer; LUSC cis rs1997103 1.000 rs9649781 chr7:55411809 A/G cg17469321 chr7:55412551 NA 0.64 10.23 0.49 1.54e-21 QRS interval (sulfonylurea treatment interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27305525 chr1:154955752 FLAD1 0.44 6.56 0.34 2e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg09184832 chr6:79620586 NA -0.45 -7.29 -0.37 2.27e-12 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7659604 0.502 rs13106764 chr4:122699630 C/G cg19748678 chr4:122722346 EXOSC9 -0.5 -7.39 -0.37 1.19e-12 Type 2 diabetes; LUSC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.07 0.52 1.72e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11122272 0.705 rs2808599 chr1:231533482 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.11 -0.48 3.98e-21 Hemoglobin concentration; LUSC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg24531977 chr5:56204891 C5orf35 -1.0 -14.74 -0.63 3.27e-38 Initial pursuit acceleration; LUSC cis rs2692947 0.727 rs2692950 chr2:96673524 T/C cg23100626 chr2:96804247 ASTL 0.25 6.2 0.32 1.66e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs709400 1.000 rs61995780 chr14:104120612 A/G cg24130564 chr14:104152367 KLC1 -0.54 -7.84 -0.39 6.08e-14 Body mass index; LUSC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg27121462 chr16:89883253 FANCA 0.56 8.95 0.44 2.48e-17 Vitiligo; LUSC cis rs9311676 0.632 rs4130877 chr3:58374893 T/C cg13750441 chr3:58318267 PXK 0.36 6.86 0.35 3.29e-11 Systemic lupus erythematosus; LUSC cis rs1775715 0.737 rs2808028 chr10:32101189 G/A cg03015672 chr10:32216066 ARHGAP12 0.33 5.84 0.3 1.22e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7914558 1.000 rs7899084 chr10:104872547 A/T cg23093090 chr10:104574429 C10orf26 -0.38 -7.05 -0.36 1.05e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs34172651 0.917 rs12599643 chr16:24832693 C/T cg06028605 chr16:24865363 SLC5A11 0.46 8.38 0.42 1.45e-15 Intelligence (multi-trait analysis); LUSC cis rs1670533 0.932 rs935968 chr4:1063187 G/T cg02018176 chr4:1364513 KIAA1530 0.42 5.75 0.3 2e-8 Recombination rate (females); LUSC cis rs7084402 0.967 rs1658469 chr10:60292402 C/T cg07615347 chr10:60278583 BICC1 -0.35 -5.7 -0.3 2.67e-8 Refractive error; LUSC cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg05283184 chr6:79620031 NA -0.57 -12.15 -0.55 2.25e-28 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.747 rs3806219 chr1:152972522 C/T cg00922841 chr1:152955080 SPRR1A 0.46 8.13 0.41 8.38e-15 Inflammatory skin disease; LUSC cis rs4722585 0.764 rs4259314 chr7:26182214 A/G cg07876897 chr7:26191696 NFE2L3 -0.42 -6.34 -0.33 7.43e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); LUSC cis rs11711311 1.000 rs1073040 chr3:113522123 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.76 -0.3 1.92e-8 IgG glycosylation; LUSC cis rs4268898 0.552 rs11125454 chr2:24373669 T/C cg06627628 chr2:24431161 ITSN2 0.51 7.27 0.37 2.53e-12 Asthma; LUSC cis rs9398803 0.865 rs1538172 chr6:126748493 A/G cg19875578 chr6:126661172 C6orf173 0.42 6.27 0.32 1.09e-9 Male-pattern baldness; LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg08470875 chr2:26401718 FAM59B -0.72 -9.9 -0.48 1.91e-20 Gut microbiome composition (summer); LUSC cis rs7587476 0.784 rs17424051 chr2:215688992 G/C cg04004882 chr2:215674386 BARD1 0.47 6.21 0.32 1.54e-9 Neuroblastoma; LUSC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg08219700 chr8:58056026 NA 0.64 8.09 0.4 1.09e-14 Developmental language disorder (linguistic errors); LUSC cis rs1009647 0.592 rs1045004 chr14:55819791 G/A cg04306507 chr14:55594613 LGALS3 0.46 6.67 0.34 1.09e-10 Testicular germ cell tumor; LUSC cis rs13223928 0.651 rs4722426 chr7:3150697 C/T cg19214707 chr7:3157722 NA 0.44 8.91 0.44 3.37e-17 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg03709012 chr19:19516395 GATAD2A 0.74 11.3 0.53 2.7e-25 Tonsillectomy; LUSC cis rs1865760 0.963 rs3846838 chr6:25911775 T/C cg16482183 chr6:26056742 HIST1H1C 0.44 6.59 0.34 1.72e-10 Height; LUSC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg24296786 chr1:45957014 TESK2 0.54 8.24 0.41 4.09e-15 High light scatter reticulocyte count; LUSC cis rs79387448 0.935 rs7567133 chr2:103253128 C/A cg09003973 chr2:102972529 NA 0.66 6.6 0.34 1.61e-10 Gut microbiota (bacterial taxa); LUSC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg18404041 chr3:52824283 ITIH1 0.49 8.02 0.4 1.76e-14 Bipolar disorder; LUSC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg03929089 chr4:120376271 NA 0.83 12.35 0.56 4.02e-29 Height; LUSC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg15448220 chr1:150897856 SETDB1 0.41 6.1 0.32 2.95e-9 Melanoma; LUSC cis rs2730245 1.000 rs2252502 chr7:158738634 G/C cg11984989 chr7:158649758 WDR60 -1.0 -17.47 -0.69 5.16e-49 Height; LUSC cis rs6543140 0.964 rs6543138 chr2:103066132 G/A cg09003973 chr2:102972529 NA 0.51 6.68 0.34 1.02e-10 Blood protein levels; LUSC cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg06552810 chr11:31128660 NA -0.4 -7.13 -0.36 6.38e-12 Red blood cell count; LUSC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg11632617 chr15:75315747 PPCDC -0.52 -6.76 -0.35 6.32e-11 Blood trace element (Zn levels); LUSC trans rs7618501 0.633 rs6772095 chr3:49978069 C/T cg21659725 chr3:3221576 CRBN 0.64 10.6 0.5 7.9e-23 Intelligence (multi-trait analysis); LUSC cis rs2806561 0.704 rs667330 chr1:23515257 A/G cg12483005 chr1:23474871 LUZP1 0.41 6.46 0.33 3.62e-10 Height; LUSC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg06640241 chr16:89574553 SPG7 0.91 17.02 0.68 3.34e-47 Multiple myeloma (IgH translocation); LUSC cis rs2625529 0.652 rs2957750 chr15:72332258 C/T cg16672083 chr15:72433130 SENP8 0.48 8.11 0.41 9.5e-15 Red blood cell count; LUSC cis rs9326248 0.559 rs482371 chr11:116752163 T/C cg01368799 chr11:117014884 PAFAH1B2 0.58 8.72 0.43 1.37e-16 Blood protein levels; LUSC cis rs9467773 1.000 rs11756120 chr6:26529808 G/C cg11502198 chr6:26597334 ABT1 0.59 9.24 0.45 2.88e-18 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.39 0.46 9.37e-19 Bipolar disorder; LUSC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg00990874 chr7:1149470 C7orf50 -0.62 -8.22 -0.41 4.6e-15 Bronchopulmonary dysplasia; LUSC cis rs28647808 0.881 rs28625799 chr9:136264557 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs921968 0.643 rs613539 chr2:219455967 G/T cg02176678 chr2:219576539 TTLL4 0.61 10.95 0.51 4.76e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs1904096 0.506 rs28522293 chr4:95167087 A/G cg11021082 chr4:95130006 SMARCAD1 -0.44 -8.08 -0.4 1.18e-14 Type 2 diabetes; LUSC cis rs7666738 0.609 rs28833816 chr4:98868866 T/C cg03676636 chr4:99064102 C4orf37 0.32 6.27 0.32 1.12e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg16447950 chr5:562315 NA -0.54 -6.69 -0.34 9.21e-11 Obesity-related traits; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg05368731 chr17:41323189 NBR1 0.93 15.91 0.66 7.9e-43 Menopause (age at onset); LUSC cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs7267979 1.000 rs6050599 chr20:25400240 T/C cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs12210905 0.920 rs9379975 chr6:27295808 T/A cg11837749 chr1:55047332 ACOT11 0.66 6.3 0.33 9.13e-10 Hip circumference adjusted for BMI; LUSC trans rs11098499 0.738 rs34566984 chr4:120361270 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.27 0.32 1.14e-9 Corneal astigmatism; LUSC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg15744005 chr10:104629667 AS3MT -0.39 -7.97 -0.4 2.58e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs909341 0.909 rs2750480 chr20:62342654 G/A cg09650180 chr20:62225654 GMEB2 -0.44 -5.67 -0.3 3.13e-8 Atopic dermatitis; LUSC cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg24692254 chr21:30365293 RNF160 -0.51 -7.52 -0.38 5.09e-13 Dental caries; LUSC cis rs2797160 1.000 rs1739357 chr6:126019655 T/G cg05901451 chr6:126070800 HEY2 0.57 8.71 0.43 1.38e-16 Endometrial cancer; LUSC trans rs2243480 1.000 rs7787230 chr7:65629099 G/A cg10756647 chr7:56101905 PSPH -0.84 -8.39 -0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg24675658 chr1:53192096 ZYG11B -0.63 -9.91 -0.48 1.78e-20 Monocyte count; LUSC cis rs28374715 0.635 rs112547435 chr15:41648737 C/G cg18705301 chr15:41695430 NDUFAF1 -0.97 -20.18 -0.74 8.73e-60 Ulcerative colitis; LUSC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg03396347 chr1:1875803 NA -0.55 -12.27 -0.56 8.21e-29 Body mass index; LUSC trans rs11098499 0.954 rs12510138 chr4:120423935 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.09e-9 Corneal astigmatism; LUSC cis rs10266483 0.739 rs55747800 chr7:63870483 C/A cg24201672 chr7:64023550 ZNF680 0.5 6.1 0.32 2.88e-9 Response to statin therapy; LUSC cis rs7712401 0.580 rs42536 chr5:122276423 T/C cg19077854 chr5:122220652 SNX24 0.42 9.41 0.46 8.49e-19 Mean platelet volume; LUSC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg07701084 chr6:150067640 NUP43 0.54 8.23 0.41 4.16e-15 Lung cancer; LUSC cis rs10050311 0.746 rs17454662 chr4:87673764 G/A cg10685359 chr4:87814065 C4orf36 -0.43 -5.66 -0.3 3.19e-8 Insulin-related traits; LUSC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg19748678 chr4:122722346 EXOSC9 0.74 11.18 0.52 7.35e-25 Type 2 diabetes; LUSC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.15 -0.36 5.49e-12 Major depressive disorder; LUSC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg12615879 chr12:58013172 SLC26A10 0.27 5.76 0.3 1.86e-8 Multiple sclerosis; LUSC cis rs6733011 0.519 rs12712034 chr2:99458933 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.33 -0.33 7.81e-10 Bipolar disorder; LUSC cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg21545522 chr1:205238299 TMCC2 0.52 9.82 0.47 3.68e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg25258033 chr6:167368657 RNASET2 -0.47 -7.95 -0.4 2.87e-14 Crohn's disease; LUSC cis rs4906332 0.782 rs12891288 chr14:103999750 C/T cg04998671 chr14:104000505 TRMT61A -0.56 -7.79 -0.39 8.43e-14 Coronary artery disease; LUSC cis rs4253772 0.530 rs9615989 chr22:46803774 A/T cg09491104 chr22:46646882 C22orf40 -0.65 -5.65 -0.3 3.5e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs6960043 0.818 rs6947830 chr7:15064984 A/G cg19272540 chr7:15055459 NA 0.3 7.42 0.38 1.01e-12 Type 2 diabetes; LUSC cis rs1971762 0.563 rs10747679 chr12:54077750 C/T cg23533419 chr12:54090519 NA -0.37 -6.02 -0.31 4.64e-9 Height; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg22308759 chr17:56064928 VEZF1 -0.42 -6.46 -0.33 3.61e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1595825 0.838 rs73058878 chr2:198895078 T/G cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs62432291 0.681 rs2932987 chr6:159655673 C/G cg14500486 chr6:159655392 FNDC1 0.5 5.74 0.3 2.17e-8 Joint mobility (Beighton score); LUSC cis rs4144027 0.791 rs67727470 chr14:104361996 A/G cg12183467 chr14:104352244 NA 0.3 5.94 0.31 7.04e-9 Blood metabolite levels; LUSC cis rs7267979 0.934 rs2482913 chr20:25405086 T/A cg03522245 chr20:25566470 NINL -0.35 -5.77 -0.3 1.83e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.53 8.16 0.41 6.74e-15 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg18305652 chr10:134549665 INPP5A 0.45 6.57 0.34 1.94e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs17661538 0.504 rs34295748 chr10:18470126 A/G cg03634479 chr10:18430412 CACNB2 0.66 6.0 0.31 4.99e-9 Response to antipsychotic treatment; LUSC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg04369109 chr6:150039330 LATS1 -0.54 -8.06 -0.4 1.4e-14 Lung cancer; LUSC cis rs6545883 0.929 rs10173974 chr2:61748900 C/G cg15711740 chr2:61764176 XPO1 -0.49 -7.82 -0.39 6.97e-14 Tuberculosis; LUSC cis rs912057 0.695 rs1294419 chr6:6742549 C/G cg06612196 chr6:6737390 NA 0.55 10.47 0.5 2.28e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs6762 0.550 rs8672 chr11:838634 C/G cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.91 -0.35 2.46e-11 Mean platelet volume; LUSC cis rs13067593 1.000 rs11715620 chr3:188563772 T/G cg17809494 chr3:188572244 LPP 0.45 6.26 0.32 1.18e-9 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs765787 0.530 rs3759893 chr15:45542950 G/T cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.04e-16 Uric acid levels; LUSC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg17971929 chr21:40555470 PSMG1 0.77 13.35 0.59 7.08e-33 Cognitive function; LUSC cis rs6906287 0.609 rs767139 chr6:118884799 A/G cg21191810 chr6:118973309 C6orf204 0.33 6.05 0.31 3.83e-9 Electrocardiographic conduction measures; LUSC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg18827107 chr12:86230957 RASSF9 -0.5 -7.58 -0.38 3.49e-13 Major depressive disorder; LUSC cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg22681709 chr2:178499509 PDE11A -0.5 -9.02 -0.44 1.47e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg06634786 chr22:41940651 POLR3H 0.49 6.05 0.31 3.88e-9 Vitiligo; LUSC cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg15848620 chr12:58087721 OS9 0.48 6.58 0.34 1.87e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs8099014 1.000 rs4940701 chr18:56110158 A/T cg12907477 chr18:56117327 MIR122 0.44 7.02 0.36 1.28e-11 Platelet count; LUSC cis rs11864453 0.713 rs9925763 chr16:72142595 C/A cg01557791 chr16:72042693 DHODH -0.48 -6.96 -0.36 1.85e-11 Fibrinogen levels; LUSC cis rs4343996 0.506 rs10274978 chr7:3433777 T/C cg21248987 chr7:3385318 SDK1 0.36 5.98 0.31 5.8e-9 Motion sickness; LUSC cis rs760794 0.729 rs2206033 chr6:19796878 A/C cg02404759 chr6:19790362 NA -0.41 -6.62 -0.34 1.42e-10 Endometriosis; LUSC cis rs17685 0.753 rs4732542 chr7:75663203 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.54 -8.44 -0.42 1e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.1e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs853679 0.607 rs13194781 chr6:27815639 A/G cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.13e-9 Depression; LUSC cis rs7095944 0.584 rs4962693 chr10:126424835 C/T cg08799069 chr10:126477246 METTL10 -0.4 -6.08 -0.32 3.26e-9 Asthma; LUSC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg02038168 chr22:39784481 NA -0.5 -8.33 -0.41 2.18e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11098499 0.779 rs10857066 chr4:120286596 C/T cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs4474465 0.920 rs7941889 chr11:78154401 T/G cg27205649 chr11:78285834 NARS2 -0.5 -5.9 -0.31 9.04e-9 Alzheimer's disease (survival time); LUSC cis rs10208940 0.920 rs34366735 chr2:68771995 A/G cg12452813 chr2:68675892 NA 0.57 5.84 0.3 1.23e-8 Urate levels in lean individuals; LUSC cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg08493051 chr2:3487164 NA 0.48 7.46 0.38 7.55e-13 Neurofibrillary tangles; LUSC cis rs2070433 0.756 rs2839295 chr21:47917871 A/T cg12379764 chr21:47803548 PCNT 0.73 9.52 0.46 3.66e-19 Lymphocyte counts; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.3 6.01 0.31 4.73e-9 Lymphocyte counts; LUSC cis rs116139393 0.656 rs10244591 chr7:6771098 G/C cg09896999 chr7:6746977 ZNF12 -0.53 -7.99 -0.4 2.23e-14 Alzheimer's disease (APOE e4 interaction); LUSC cis rs9393692 0.967 rs6456712 chr6:26302573 A/C cg13736514 chr6:26305472 NA -0.48 -9.6 -0.46 1.99e-19 Educational attainment; LUSC cis rs790123 0.965 rs2133850 chr3:122381696 C/T cg17380795 chr3:122379686 NA 0.35 5.65 0.3 3.41e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs12545109 0.837 rs6474063 chr8:57355545 C/T cg09654669 chr8:57350985 NA -0.54 -7.43 -0.38 9.23e-13 Obesity-related traits; LUSC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.49e-15 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.614 rs4236537 chr7:97996593 T/C cg09267113 chr7:98030324 BAIAP2L1 -0.73 -10.3 -0.49 8.61e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg24450063 chr1:156163899 SLC25A44 1.07 17.26 0.69 3.57e-48 Testicular germ cell tumor; LUSC cis rs2075371 0.501 rs1421469 chr7:134028260 C/G cg20476274 chr7:133979776 SLC35B4 0.7 11.8 0.54 4.23e-27 Mean platelet volume; LUSC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg20735989 chr4:730612 PCGF3 -0.45 -6.58 -0.34 1.81e-10 White blood cell count; LUSC cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.4 -0.42 1.3e-15 Schizophrenia; LUSC trans rs11039798 0.778 rs7944523 chr11:48911019 G/A cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18099408 chr3:52552593 STAB1 -0.41 -6.97 -0.36 1.74e-11 Bipolar disorder; LUSC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg09323728 chr8:95962352 TP53INP1 -0.34 -6.36 -0.33 6.56e-10 Type 2 diabetes; LUSC cis rs9653442 0.545 rs4851252 chr2:100757280 C/T cg07810366 chr2:100720526 AFF3 -0.43 -7.12 -0.36 6.55e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2729354 1.000 rs2729355 chr11:57353983 T/G cg24343310 chr11:57249947 NA 0.36 6.5 0.34 2.89e-10 Blood protein levels; LUSC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11890956 chr21:40555474 PSMG1 0.9 16.42 0.67 7.71e-45 Cognitive function; LUSC cis rs12908161 1.000 rs35316992 chr15:85248133 A/G cg17507749 chr15:85114479 UBE2QP1 0.56 6.91 0.35 2.45e-11 Schizophrenia; LUSC cis rs12579753 1.000 rs11613196 chr12:82173251 A/T cg07988820 chr12:82153109 PPFIA2 0.44 6.2 0.32 1.7e-9 Resting heart rate; LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg02018176 chr4:1364513 KIAA1530 0.52 9.14 0.45 6.17e-18 Obesity-related traits; LUSC trans rs61931739 0.517 rs4931771 chr12:34044557 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.36 0.42 1.74e-15 Morning vs. evening chronotype; LUSC cis rs9611565 0.571 rs2050032 chr22:42152429 C/T cg03806693 chr22:41940476 POLR3H 0.88 12.7 0.57 2e-30 Vitiligo; LUSC cis rs7107174 1.000 rs2511186 chr11:77984306 C/G cg02023728 chr11:77925099 USP35 0.47 6.87 0.35 3.08e-11 Testicular germ cell tumor; LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg22963979 chr7:1858916 MAD1L1 -0.47 -6.89 -0.35 2.72e-11 Bipolar disorder and schizophrenia; LUSC trans rs8002861 0.935 rs1373903 chr13:44475514 G/T cg12856521 chr11:46389249 DGKZ 0.4 6.16 0.32 2.1e-9 Leprosy; LUSC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg17279839 chr7:150038598 RARRES2 0.47 7.33 0.37 1.79e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs34311866 0.808 rs3755958 chr4:963042 C/A cg14530993 chr4:882597 GAK 0.69 6.84 0.35 3.88e-11 Parkinson's disease; LUSC cis rs68170813 0.559 rs12537730 chr7:106844281 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.49e-20 Coronary artery disease; LUSC cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg08213375 chr14:104286397 PPP1R13B -0.45 -8.25 -0.41 3.65e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01151686 chr17:33307622 LIG3 -0.46 -6.89 -0.35 2.83e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg07332563 chr6:291687 DUSP22 -0.7 -11.9 -0.55 1.84e-27 Menopause (age at onset); LUSC cis rs6121246 0.559 rs12479491 chr20:30265450 T/C cg13852791 chr20:30311386 BCL2L1 0.96 14.96 0.63 4.25e-39 Mean corpuscular hemoglobin; LUSC cis rs7223966 1.000 rs7211213 chr17:61769456 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.13 0.36 6.23e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg01475377 chr6:109611718 NA -0.37 -6.46 -0.33 3.61e-10 Reticulocyte fraction of red cells; LUSC cis rs6430585 0.640 rs3816155 chr2:136552526 A/C cg07169764 chr2:136633963 MCM6 -1.13 -16.99 -0.68 4.34e-47 Corneal structure; LUSC cis rs6089584 0.507 rs6061990 chr20:60628429 T/G cg06108461 chr20:60628389 TAF4 -0.75 -12.37 -0.56 3.48e-29 Body mass index; LUSC cis rs76878669 0.561 rs2236679 chr11:66108894 G/C cg24851651 chr11:66362959 CCS 0.37 5.78 0.3 1.76e-8 Educational attainment (years of education); LUSC cis rs826838 0.904 rs1554550 chr12:39208889 G/A cg26384229 chr12:38710491 ALG10B 0.87 15.49 0.65 3.77e-41 Heart rate; LUSC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.55 8.3 0.41 2.69e-15 Total body bone mineral density; LUSC cis rs1018697 0.897 rs2150929 chr10:104550937 T/A cg04362960 chr10:104952993 NT5C2 0.47 6.5 0.34 2.96e-10 Colorectal adenoma (advanced); LUSC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.28e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg13393036 chr8:95962371 TP53INP1 0.34 6.81 0.35 4.44e-11 Type 2 diabetes; LUSC cis rs6545883 0.831 rs9309336 chr2:61763165 T/C cg15711740 chr2:61764176 XPO1 -0.5 -7.87 -0.4 5.05e-14 Tuberculosis; LUSC cis rs9300255 0.568 rs3018098 chr12:123654812 T/C cg05973401 chr12:123451056 ABCB9 0.53 6.54 0.34 2.3e-10 Neutrophil percentage of white cells; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg22963979 chr7:1858916 MAD1L1 0.57 9.1 0.45 8.32e-18 Bipolar disorder and schizophrenia; LUSC trans rs11700980 0.591 rs73901413 chr21:30109304 T/C cg14791747 chr16:20752902 THUMPD1 0.55 5.98 0.31 5.75e-9 QRS complex (12-leadsum); LUSC cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg26380479 chr7:97908229 NA -0.27 -5.85 -0.3 1.16e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs34421088 0.623 rs2572433 chr8:11101041 C/T cg06636001 chr8:8085503 FLJ10661 0.52 7.07 0.36 9.15e-12 Neuroticism; LUSC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg24675056 chr1:15929824 NA 0.46 7.96 0.4 2.79e-14 Systolic blood pressure; LUSC cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.75 0.51 2.36e-23 Bladder cancer; LUSC cis rs4654899 0.795 rs61309203 chr1:21118489 A/T cg01072550 chr1:21505969 NA -0.44 -6.53 -0.34 2.38e-10 Superior frontal gyrus grey matter volume; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -7.55 -0.38 4.09e-13 Renal function-related traits (BUN); LUSC cis rs13256369 0.789 rs13282500 chr8:8568489 A/T cg00074818 chr8:8560427 CLDN23 0.49 8.45 0.42 9.39e-16 Obesity-related traits; LUSC cis rs796364 0.587 rs7588746 chr2:200986345 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.49 6.2 0.32 1.71e-9 Schizophrenia; LUSC cis rs7511006 0.893 rs2038049 chr22:50654888 G/C cg16473166 chr22:50639996 SELO 0.68 9.65 0.47 1.34e-19 Obesity-related traits; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -11.09 -0.52 1.5e-24 Alzheimer's disease; LUSC cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg17507749 chr15:85114479 UBE2QP1 0.5 6.2 0.32 1.67e-9 Schizophrenia; LUSC cis rs7621025 0.500 rs71630059 chr3:136581611 G/A cg15507776 chr3:136538369 TMEM22 -0.62 -8.29 -0.41 2.76e-15 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; LUSC cis rs754133 1.000 rs754133 chr12:54418920 C/T cg10005224 chr12:54424964 HOXC4;HOXC5 0.43 8.66 0.43 2.02e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs3087591 0.960 rs2905787 chr17:29482381 G/A cg24425628 chr17:29625626 OMG;NF1 0.6 8.42 0.42 1.15e-15 Hip circumference; LUSC cis rs8040855 0.627 rs11634975 chr15:85606478 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -5.74 -0.3 2.08e-8 Bulimia nervosa; LUSC cis rs7584330 0.868 rs7571898 chr2:238383028 T/C cg14458575 chr2:238380390 NA 0.68 11.41 0.53 1.06e-25 Prostate cancer; LUSC cis rs1003719 0.688 rs2000416 chr21:38540089 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -9.79 -0.47 4.62e-20 Eye color traits; LUSC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg24675056 chr1:15929824 NA 0.46 7.92 0.4 3.44e-14 Systolic blood pressure; LUSC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg02569458 chr12:86230093 RASSF9 -0.49 -8.25 -0.41 3.64e-15 Major depressive disorder; LUSC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg26408565 chr15:76604113 ETFA -0.5 -8.11 -0.41 9.51e-15 Blood metabolite levels; LUSC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg06481639 chr22:41940642 POLR3H -0.53 -5.98 -0.31 5.59e-9 Vitiligo; LUSC cis rs1371867 0.846 rs1660329 chr8:101304048 G/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.93e-13 Atrioventricular conduction; LUSC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg08680598 chr22:49984980 NA -0.34 -6.29 -0.33 1e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg20503657 chr10:835505 NA 0.82 11.75 0.54 6.55e-27 Eosinophil percentage of granulocytes; LUSC cis rs1577917 1.000 rs12201571 chr6:86609750 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs734999 0.505 rs10797438 chr1:2540262 C/T cg18854424 chr1:2615690 NA 0.52 10.79 0.51 1.71e-23 Ulcerative colitis; LUSC cis rs710216 0.957 rs841563 chr1:43429520 C/T cg03128534 chr1:43423976 SLC2A1 0.47 5.82 0.3 1.36e-8 Red cell distribution width; LUSC cis rs72634258 0.836 rs9658012 chr1:7989022 C/T cg26816564 chr1:7831052 VAMP3 0.57 6.56 0.34 2.08e-10 Inflammatory bowel disease; LUSC cis rs11098499 0.954 rs7681544 chr4:120411255 T/C cg24375607 chr4:120327624 NA 0.79 12.05 0.55 5.19e-28 Corneal astigmatism; LUSC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs113835537 0.935 rs76228630 chr11:66458676 T/C cg24851651 chr11:66362959 CCS 0.52 6.42 0.33 4.69e-10 Airway imaging phenotypes; LUSC trans rs4800353 0.929 rs4267422 chr18:19608303 C/T cg01841828 chr16:69166849 CHTF8;CIRH1A -0.58 -6.05 -0.31 3.85e-9 Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs73206853 0.841 rs3026456 chr12:110748735 G/C cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4253772 0.938 rs14842 chr22:46639457 A/T cg09491104 chr22:46646882 C22orf40 -0.63 -6.52 -0.34 2.57e-10 LDL cholesterol;Cholesterol, total; LUSC trans rs2562456 0.793 rs116057198 chr19:21508451 A/G cg00806126 chr19:22604979 ZNF98 -0.42 -5.99 -0.31 5.56e-9 Pain; LUSC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs34779708 0.931 rs4934709 chr10:35339324 A/C cg04310649 chr10:35416472 CREM 0.4 6.15 0.32 2.17e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6964587 1.000 rs7785095 chr7:91640773 A/T cg22709100 chr7:91322751 NA -0.39 -5.75 -0.3 2.06e-8 Breast cancer; LUSC cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg03264133 chr6:25882463 NA -0.5 -9.07 -0.44 1.04e-17 Blood metabolite levels; LUSC cis rs9650657 0.836 rs2898252 chr8:10604164 T/C cg27411982 chr8:10470053 RP1L1 -0.36 -5.78 -0.3 1.76e-8 Neuroticism; LUSC cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg08999081 chr20:33150536 PIGU 0.51 10.22 0.49 1.68e-21 Glomerular filtration rate (creatinine); LUSC cis rs3736594 1.000 rs12477908 chr2:27987046 A/C cg27432699 chr2:27873401 GPN1 -0.62 -8.98 -0.44 1.96e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg10523679 chr1:76189770 ACADM -0.9 -14.4 -0.62 6.4e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg21782813 chr7:2030301 MAD1L1 0.49 8.37 0.42 1.56e-15 Bipolar disorder and schizophrenia; LUSC cis rs7818345 0.845 rs11785649 chr8:19268233 G/A cg11303988 chr8:19266685 CSGALNACT1 0.32 6.15 0.32 2.22e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6598955 0.543 rs4585968 chr1:26535146 G/A cg04990556 chr1:26633338 UBXN11 0.85 11.14 0.52 9.76e-25 Obesity-related traits; LUSC cis rs75804782 0.521 rs56120037 chr2:239398464 G/A cg18131467 chr2:239335373 ASB1 -0.67 -6.17 -0.32 2e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg23172400 chr8:95962367 TP53INP1 -0.37 -7.13 -0.36 6.33e-12 Type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10566763 chr6:106773518 ATG5 -0.52 -6.6 -0.34 1.65e-10 Bipolar disorder and schizophrenia; LUSC cis rs6542838 0.611 rs1878589 chr2:99517979 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.49 -0.33 3.16e-10 Fear of minor pain; LUSC cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg18252515 chr7:66147081 NA -0.57 -7.86 -0.39 5.44e-14 Corneal structure; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16080015 chr7:5085479 RBAK -0.48 -7.16 -0.36 5.12e-12 Electrocardiographic conduction measures; LUSC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1358748 0.522 rs6687611 chr1:67558169 T/C cg02640540 chr1:67518911 SLC35D1 0.66 6.61 0.34 1.5e-10 Tuberculosis; LUSC cis rs4077515 0.967 rs11145874 chr9:139290011 G/A cg14019695 chr9:139328340 INPP5E 0.45 8.53 0.42 5.23e-16 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg03517284 chr6:25882590 NA -0.54 -8.97 -0.44 2.23e-17 Intelligence (multi-trait analysis); LUSC cis rs2721195 0.626 rs59464125 chr8:145857786 G/A cg17328964 chr8:145687451 CYHR1 0.47 7.45 0.38 8.17e-13 Age at first birth; LUSC trans rs61931739 0.793 rs609886 chr12:34138160 T/G cg26384229 chr12:38710491 ALG10B 0.56 8.72 0.43 1.33e-16 Morning vs. evening chronotype; LUSC cis rs11229555 0.609 rs12289198 chr11:58175057 T/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs295137 0.836 rs1217429 chr2:201094151 G/T cg23649088 chr2:200775458 C2orf69 0.47 7.06 0.36 9.69e-12 Asthma (bronchodilator response); LUSC cis rs9473147 0.516 rs9381579 chr6:47556680 C/T cg12968598 chr6:47444699 CD2AP 0.52 7.93 0.4 3.32e-14 Platelet distribution width;Mean platelet volume; LUSC trans rs7618501 0.602 rs2013208 chr3:50129399 C/T cg21659725 chr3:3221576 CRBN -0.61 -9.93 -0.48 1.58e-20 Intelligence (multi-trait analysis); LUSC cis rs4820539 0.966 rs5759594 chr22:23470660 G/A cg21100191 chr22:23484243 RTDR1 0.92 16.16 0.66 8.69e-44 Bone mineral density; LUSC cis rs11168618 0.567 rs56354789 chr12:48803943 C/A cg24011408 chr12:48396354 COL2A1 0.42 6.6 0.34 1.6e-10 Adiponectin levels; LUSC cis rs10992471 0.528 rs7031567 chr9:95241363 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.36 -6.22 -0.32 1.5e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2274273 0.870 rs1952087 chr14:55683211 A/C cg04306507 chr14:55594613 LGALS3 0.57 12.96 0.58 2.1e-31 Protein biomarker; LUSC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg15445000 chr17:37608096 MED1 0.39 6.63 0.34 1.37e-10 Urinary metabolites; LUSC cis rs79387448 0.745 rs72993754 chr2:103151136 A/G cg09003973 chr2:102972529 NA 0.75 7.41 0.38 1.01e-12 Gut microbiota (bacterial taxa); LUSC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg08470875 chr2:26401718 FAM59B 0.71 9.8 0.47 4.22e-20 Gut microbiome composition (summer); LUSC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg18230493 chr5:56204884 C5orf35 -0.86 -12.98 -0.58 1.85e-31 Initial pursuit acceleration; LUSC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs3858526 0.834 rs10838986 chr11:5977065 A/G cg05234568 chr11:5960015 NA -0.63 -8.89 -0.44 3.96e-17 DNA methylation (variation); LUSC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg22875332 chr1:76189707 ACADM 0.82 14.39 0.62 7.5e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4964805 0.657 rs4964813 chr12:104189554 T/C cg02344784 chr12:104178138 NT5DC3 0.46 8.86 0.44 4.8e-17 Attention deficit hyperactivity disorder; LUSC cis rs952623 0.649 rs7801660 chr7:39072473 C/T cg15212455 chr7:39170539 POU6F2 0.36 5.96 0.31 6.42e-9 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.765 rs9457256 chr6:167436461 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.83 -0.3 1.31e-8 Crohn's disease; LUSC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg15664640 chr17:80829946 TBCD -0.48 -8.86 -0.44 4.97e-17 Breast cancer; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.28e-9 Menopause (age at onset); LUSC cis rs2479724 0.875 rs2253961 chr6:41827011 A/G cg17623882 chr6:41773611 USP49 -0.58 -9.94 -0.48 1.46e-20 Menarche (age at onset); LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg07870213 chr5:140052090 DND1 0.99 14.68 0.63 5.57e-38 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg24675056 chr1:15929824 NA 0.48 8.27 0.41 3.15e-15 Systolic blood pressure; LUSC cis rs12900413 0.687 rs12913572 chr15:90319313 T/C cg24249390 chr15:90295951 MESP1 -0.37 -5.85 -0.31 1.15e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs7927771 0.524 rs7936948 chr11:47704200 T/G cg20307385 chr11:47447363 PSMC3 0.45 6.5 0.34 2.87e-10 Subjective well-being; LUSC cis rs10979 1.000 rs9390107 chr6:143892721 A/T cg25407410 chr6:143891975 LOC285740 -0.73 -11.95 -0.55 1.25e-27 Hypospadias; LUSC cis rs4072705 1.000 rs10760372 chr9:127468816 T/C cg13476313 chr9:127244764 NR5A1 0.29 5.66 0.3 3.21e-8 Menarche (age at onset); LUSC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg06238570 chr21:40685208 BRWD1 0.46 7.12 0.36 6.54e-12 Cognitive function; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg13560548 chr3:10150139 C3orf24 0.47 6.65 0.34 1.23e-10 Alzheimer's disease; LUSC cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg06784218 chr1:46089804 CCDC17 0.55 10.98 0.52 3.63e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg26384229 chr12:38710491 ALG10B 0.64 10.05 0.48 5.93e-21 Morning vs. evening chronotype; LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg14092988 chr3:52407081 DNAH1 0.33 6.3 0.33 9.43e-10 Bipolar disorder; LUSC cis rs3741151 0.892 rs60078907 chr11:73085834 T/C cg17517138 chr11:73019481 ARHGEF17 0.83 7.53 0.38 4.94e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs300703 0.748 rs4484059 chr2:286812 G/A cg21211680 chr2:198530 NA 0.75 7.59 0.38 3.18e-13 Blood protein levels; LUSC trans rs11098499 0.865 rs4001305 chr4:120359236 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.4 0.33 5.41e-10 Corneal astigmatism; LUSC cis rs9420 0.925 rs10896636 chr11:57448032 C/G cg02958346 chr11:57425731 CLP1 -0.45 -6.57 -0.34 1.98e-10 Schizophrenia; LUSC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg13047869 chr3:10149882 C3orf24 0.43 6.53 0.34 2.46e-10 Alzheimer's disease; LUSC cis rs977987 0.872 rs1559339 chr16:75318646 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.82 -0.35 4.28e-11 Dupuytren's disease; LUSC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg18099408 chr3:52552593 STAB1 -0.37 -6.18 -0.32 1.91e-9 Bipolar disorder; LUSC cis rs10193935 0.901 rs10169411 chr2:42637749 G/A cg27598129 chr2:42591480 NA -0.61 -8.27 -0.41 3.18e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg17366294 chr4:99064904 C4orf37 0.61 10.86 0.51 1.01e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg15147215 chr3:52552868 STAB1 -0.32 -6.39 -0.33 5.73e-10 Electroencephalogram traits; LUSC cis rs7814319 0.901 rs13253635 chr8:97240847 A/G cg20787634 chr8:97240163 UQCRB -0.34 -5.92 -0.31 7.93e-9 Lung function (FVC); LUSC cis rs73001065 0.536 rs10408596 chr19:19512657 A/T cg03709012 chr19:19516395 GATAD2A 0.95 8.75 0.43 1.11e-16 LDL cholesterol; LUSC cis rs6969780 0.778 rs2465275 chr7:27145100 G/A cg26364809 chr7:27145159 NA -0.62 -6.21 -0.32 1.54e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19260500 chr3:133969278 RYK -0.4 -6.16 -0.32 2.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg25036284 chr2:26402008 FAM59B -0.71 -10.02 -0.48 7.79e-21 Gut microbiome composition (summer); LUSC cis rs17095355 0.901 rs12240333 chr10:111743972 T/A cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.48 -0.38 6.7e-13 Biliary atresia; LUSC cis rs7904368 0.754 rs17139234 chr10:16849732 G/T cg23933602 chr10:16859644 RSU1 0.58 6.75 0.35 6.52e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg21970626 chr13:21893289 NA -0.4 -5.7 -0.3 2.7e-8 White matter hyperintensity burden; LUSC trans rs11098499 0.863 rs9997631 chr4:120469995 C/G cg25214090 chr10:38739885 LOC399744 0.53 7.94 0.4 3.08e-14 Corneal astigmatism; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg24813613 chr7:1882135 MAD1L1 -0.43 -7.21 -0.37 3.77e-12 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg23711669 chr6:146136114 FBXO30 -0.92 -17.89 -0.7 1.16e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg11871910 chr12:69753446 YEATS4 0.95 17.8 0.7 2.59e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg09359103 chr1:154839909 KCNN3 -0.71 -16.35 -0.67 1.43e-44 Prostate cancer; LUSC cis rs733592 0.723 rs10875766 chr12:48593580 G/C cg24011408 chr12:48396354 COL2A1 0.49 8.18 0.41 5.86e-15 Plateletcrit; LUSC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg11366901 chr6:160182831 ACAT2 0.93 13.08 0.58 7.49e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs559928 0.606 rs11231726 chr11:63987339 C/T cg05555928 chr11:63887634 MACROD1 -0.46 -5.81 -0.3 1.49e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4243830 1.000 rs12047931 chr1:6587614 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.95 8.93 0.44 2.84e-17 Body mass index; LUSC cis rs4363385 0.747 rs7521181 chr1:152955223 G/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.54 -0.38 4.34e-13 Inflammatory skin disease; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg07424592 chr7:64974309 NA 0.42 5.95 0.31 6.7e-9 Calcium levels; LUSC cis rs9467773 0.869 rs9295689 chr6:26455811 T/C cg09904177 chr6:26538194 HMGN4 0.63 10.52 0.5 1.46e-22 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs1041481 chr6:135335063 G/A cg24558204 chr6:135376177 HBS1L 0.59 9.07 0.44 1.01e-17 Red blood cell count; LUSC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg03709012 chr19:19516395 GATAD2A 0.76 11.7 0.54 1e-26 Tonsillectomy; LUSC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg07157834 chr1:205819609 PM20D1 0.42 5.67 0.3 3.1e-8 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg04539111 chr16:67997858 SLC12A4 -0.47 -6.3 -0.33 9.58e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs17253792 0.822 rs78386830 chr14:56069224 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg07061783 chr6:25882402 NA 0.43 6.11 0.32 2.71e-9 Blood metabolite levels; LUSC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg16524733 chr11:117070046 TAGLN 0.43 7.42 0.38 9.88e-13 Blood protein levels; LUSC cis rs6939532 0.522 rs9366652 chr6:26354219 C/G cg09904177 chr6:26538194 HMGN4 -0.47 -6.87 -0.35 3.14e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg14829155 chr15:31115871 NA -0.58 -8.48 -0.42 7.45e-16 Huntington's disease progression; LUSC cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg22681709 chr2:178499509 PDE11A -0.61 -12.26 -0.56 8.57e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11650494 0.710 rs77653195 chr17:47468868 A/T cg08112188 chr17:47440006 ZNF652 1.07 8.75 0.43 1.07e-16 Prostate cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01247845 chr5:68513627 MRPS36 -0.43 -6.34 -0.33 7.65e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1808579 0.804 rs1652376 chr18:21109466 A/C cg14672496 chr18:21087552 C18orf8 -0.4 -7.09 -0.36 7.98e-12 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs2239815 0.545 rs5762855 chr22:29246605 A/T cg02153584 chr22:29168773 CCDC117 0.53 6.06 0.31 3.71e-9 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs78545713 0.649 rs16891464 chr6:26235300 A/G cg23601095 chr6:26197514 HIST1H3D 0.62 5.97 0.31 6.23e-9 Iron status biomarkers (total iron binding capacity); LUSC cis rs3809863 0.646 rs9899121 chr17:45395144 C/T cg25173405 chr17:45401733 C17orf57 -0.46 -6.74 -0.35 6.91e-11 Glaucoma (primary open-angle); LUSC cis rs1670533 1.000 rs4690213 chr4:1054868 C/T cg27284194 chr4:1044797 NA 0.6 8.88 0.44 4.09e-17 Recombination rate (females); LUSC cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -8.27 -0.41 3.31e-15 Axial length; LUSC cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC trans rs4332037 0.539 rs11762545 chr7:2060775 C/T cg11693508 chr17:37793320 STARD3 0.56 6.7 0.34 8.71e-11 Bipolar disorder; LUSC cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg08645402 chr16:4508243 NA -0.47 -7.43 -0.38 8.94e-13 Schizophrenia; LUSC cis rs6546550 0.869 rs6712827 chr2:70156540 C/G cg02498382 chr2:70120550 SNRNP27 -0.29 -7.28 -0.37 2.34e-12 Prevalent atrial fibrillation; LUSC cis rs2524005 1.000 rs2524005 chr6:29899677 C/T cg27642588 chr6:29709602 LOC285830 0.49 7.91 0.4 3.76e-14 Bipolar disorder and schizophrenia; LUSC cis rs6459788 0.693 rs35146559 chr7:157238557 G/A cg03453431 chr7:157225567 NA -0.59 -10.72 -0.51 3.12e-23 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs6460942 0.908 rs6979046 chr7:12232744 A/G cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs9905704 0.718 rs62083527 chr17:56667853 T/C cg12560992 chr17:57184187 TRIM37 0.51 5.91 0.31 8.67e-9 Testicular germ cell tumor; LUSC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg17173187 chr15:85201210 NMB -0.31 -6.37 -0.33 6.29e-10 P wave terminal force; LUSC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.97 0.4 2.56e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs4843747 0.671 rs28451517 chr16:88109127 A/C cg26811252 chr16:29126840 RRN3P2 0.6 9.5 0.46 4.09e-19 Menopause (age at onset); LUSC trans rs9951602 0.512 rs12455566 chr18:76655926 A/G cg02800362 chr5:177631904 HNRNPAB 0.87 12.81 0.57 8.07e-31 Obesity-related traits; LUSC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg08045932 chr20:61659980 NA 0.59 10.39 0.49 4.1e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs6066835 1.000 rs6125446 chr20:47348161 C/G cg18078177 chr20:47281410 PREX1 0.71 6.23 0.32 1.42e-9 Multiple myeloma; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11205200 chr9:131267365 GLE1 -0.49 -6.43 -0.33 4.47e-10 Hepatitis; LUSC cis rs7119 0.717 rs34194537 chr15:77795761 G/A cg05673287 chr15:77411982 SGK269 -0.44 -6.87 -0.35 3.09e-11 Type 2 diabetes; LUSC cis rs79976124 0.837 rs12194087 chr6:66644399 T/A cg07460842 chr6:66804631 NA 0.7 8.78 0.43 8.43e-17 Type 2 diabetes; LUSC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg22920501 chr2:26401640 FAM59B 0.69 9.18 0.45 4.48e-18 Gut microbiome composition (summer); LUSC cis rs11690935 0.959 rs67204065 chr2:172672624 G/A cg13550731 chr2:172543902 DYNC1I2 -0.85 -13.92 -0.61 4.84e-35 Schizophrenia; LUSC cis rs9837602 1.000 rs9833888 chr3:99723580 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.11 0.32 2.75e-9 Breast cancer; LUSC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg05802129 chr4:122689817 NA -0.37 -6.56 -0.34 2.06e-10 Type 2 diabetes; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg13453750 chr1:205783389 SLC41A1 -0.3 -5.9 -0.31 8.7e-9 Menarche (age at onset); LUSC cis rs6998277 1.000 rs4734648 chr8:103635994 G/A cg10187029 chr8:103597600 NA 0.65 8.22 0.41 4.41e-15 Migraine; LUSC cis rs10896135 0.526 rs484262 chr11:66399681 C/T cg24851651 chr11:66362959 CCS -0.51 -8.01 -0.4 1.95e-14 Bipolar disorder; LUSC trans rs4332037 0.851 rs73050128 chr7:1961882 C/A cg10840412 chr1:235813424 GNG4 0.7 9.47 0.46 5.13e-19 Bipolar disorder; LUSC cis rs9527 0.615 rs10883804 chr10:104706520 G/A cg05855489 chr10:104503620 C10orf26 0.52 8.08 0.4 1.19e-14 Arsenic metabolism; LUSC cis rs4253772 0.591 rs11705624 chr22:46685380 C/T cg18190219 chr22:46762943 CELSR1 -0.55 -6.28 -0.33 1.05e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg22782873 chr19:19639568 YJEFN3 -0.48 -5.8 -0.3 1.53e-8 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09199072 chr6:116692265 DSE -0.42 -6.0 -0.31 5.12e-9 Bipolar disorder and schizophrenia; LUSC cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg15704280 chr7:45808275 SEPT13 -1.01 -16.85 -0.68 1.61e-46 Coronary artery disease; LUSC cis rs4242434 0.698 rs10104039 chr8:22538384 A/G cg03733263 chr8:22462867 KIAA1967 -0.72 -11.63 -0.54 1.79e-26 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs9549260 0.755 rs2755216 chr13:41156938 G/A cg21288729 chr13:41239152 FOXO1 0.6 9.35 0.46 1.26e-18 Red blood cell count; LUSC cis rs2629540 0.855 rs12776722 chr10:126469833 G/A cg08799069 chr10:126477246 METTL10 0.7 10.08 0.48 4.82e-21 Cocaine dependence; LUSC cis rs11098499 1.000 rs1011054 chr4:120202387 A/G cg24375607 chr4:120327624 NA -0.75 -11.45 -0.53 7.96e-26 Corneal astigmatism; LUSC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg23711669 chr6:146136114 FBXO30 -0.7 -12.22 -0.56 1.23e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs3806843 0.966 rs3756341 chr5:140171194 C/T cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.43e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2997447 0.744 rs2997442 chr1:26403530 T/G cg19633962 chr1:26362018 EXTL1 -0.48 -5.76 -0.3 1.89e-8 QRS complex (12-leadsum); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg26690232 chr1:40506155 CAP1 0.68 6.4 0.33 5.37e-10 Body mass index; LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.96 -12.61 -0.57 4.4e-30 Platelet count; LUSC cis rs2404602 0.684 rs157759 chr15:76846990 T/A cg23625390 chr15:77176239 SCAPER 0.63 9.56 0.46 2.7e-19 Blood metabolite levels; LUSC cis rs1371867 0.875 rs2439456 chr8:101336874 C/T cg00191853 chr8:101177733 SPAG1 -0.38 -6.31 -0.33 9.08e-10 Atrioventricular conduction; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg13397359 chr6:42928475 GNMT 0.57 9.58 0.46 2.25e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.55 7.58 0.38 3.38e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6545883 0.894 rs778148 chr2:61606866 G/A cg15711740 chr2:61764176 XPO1 0.41 6.21 0.32 1.6e-9 Tuberculosis; LUSC cis rs17433780 0.928 rs10922533 chr1:89456659 C/G cg09516651 chr1:89888402 LOC400759 0.49 8.13 0.41 8.65e-15 Carotid intima media thickness; LUSC cis rs10504073 0.506 rs7007271 chr8:49941897 T/C cg00325661 chr8:49890786 NA 0.68 10.65 0.5 5.36e-23 Blood metabolite ratios; LUSC trans rs3960554 0.808 rs78811105 chr7:75702795 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 9.54 0.46 3.1400000000000002e-19 Eotaxin levels; LUSC cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg05347473 chr6:146136440 FBXO30 0.49 8.16 0.41 6.84e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg16447950 chr5:562315 NA -0.58 -7.11 -0.36 7.26e-12 Obesity-related traits; LUSC cis rs4499344 0.556 rs259220 chr19:33137629 T/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.94 13.84 0.6 9.41e-35 Mean platelet volume; LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 15.47 0.65 4.22e-41 Platelet count; LUSC cis rs983392 0.679 rs4938932 chr11:60033448 C/T cg24026212 chr11:59952134 MS4A6A 0.36 6.2 0.32 1.71e-9 Alzheimer's disease (late onset); LUSC cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -7.65 -0.39 2.2e-13 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs3740713 1.000 rs75740864 chr11:18470689 C/G cg23797887 chr11:18477753 LDHAL6A -0.56 -6.77 -0.35 5.8e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg03804128 chr16:635623 NA 0.3 5.84 0.3 1.25e-8 Height; LUSC cis rs2836633 0.931 rs2836635 chr21:40069850 A/G cg12884169 chr21:40033163 ERG 0.56 11.17 0.52 8.17e-25 Coronary artery disease; LUSC cis rs6489785 0.735 rs12825746 chr12:121268033 A/C cg02419362 chr12:121203948 SPPL3 0.4 7.21 0.37 3.86e-12 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7212590 0.618 rs35806089 chr17:57943906 A/G cg10252138 chr17:58120427 NA -0.72 -7.02 -0.36 1.22e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg16797656 chr11:68205561 LRP5 0.36 6.06 0.31 3.77e-9 Total body bone mineral density; LUSC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg23262073 chr20:60523788 NA -0.45 -6.52 -0.34 2.66e-10 Body mass index; LUSC cis rs6964587 1.000 rs9690208 chr7:91735613 T/A cg22117172 chr7:91764530 CYP51A1 0.32 5.73 0.3 2.25e-8 Breast cancer; LUSC cis rs951366 0.538 rs56276813 chr1:205730573 G/T cg07167872 chr1:205819463 PM20D1 -0.43 -5.83 -0.3 1.31e-8 Menarche (age at onset); LUSC cis rs740160 0.510 rs12112936 chr7:98899500 G/A cg24650262 chr7:98904301 NA 0.61 6.84 0.35 3.73e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs909674 0.734 rs1005522 chr22:39845898 C/A cg24399712 chr22:39784796 NA -0.55 -8.35 -0.42 1.85e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs1005224 0.895 rs11624114 chr14:76131800 A/G cg25116370 chr14:76127843 TTLL5;C14orf1 -0.4 -5.84 -0.3 1.21e-8 Large artery stroke; LUSC cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg05043794 chr9:111880884 C9orf5 0.34 7.61 0.38 2.84e-13 Menarche (age at onset); LUSC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg13319975 chr6:146136371 FBXO30 -0.51 -7.58 -0.38 3.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2797160 1.000 rs6904992 chr6:126016003 G/A cg05901451 chr6:126070800 HEY2 0.57 8.64 0.43 2.36e-16 Endometrial cancer; LUSC cis rs3820068 0.580 rs61169376 chr1:16003832 A/G cg24675056 chr1:15929824 NA 0.42 6.99 0.36 1.49e-11 Systolic blood pressure; LUSC cis rs5769707 0.681 rs9616329 chr22:50026314 G/A cg05373962 chr22:49881684 NA -0.39 -8.51 -0.42 6.05e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg12927641 chr6:109611667 NA -0.43 -7.58 -0.38 3.41e-13 Reticulocyte fraction of red cells; LUSC cis rs34734847 0.787 rs658521 chr12:121162414 G/T cg27246729 chr12:121163418 ACADS 0.41 6.51 0.34 2.75e-10 Mean corpuscular volume; LUSC cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg17509989 chr5:176798049 RGS14 0.66 10.55 0.5 1.24e-22 Hemoglobin concentration;Hematocrit; LUSC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs1595825 0.945 rs2139050 chr2:198852636 A/G cg10547527 chr2:198650123 BOLL -0.49 -5.69 -0.3 2.76e-8 Ulcerative colitis; LUSC cis rs6964587 0.934 rs35968894 chr7:91762145 A/G cg17063962 chr7:91808500 NA 0.56 8.3 0.41 2.7e-15 Breast cancer; LUSC trans rs1728785 1.000 rs7192341 chr16:68569224 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.68 0.39 1.77e-13 Ulcerative colitis; LUSC cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg11766577 chr21:47581405 C21orf56 -0.43 -6.35 -0.33 7e-10 Testicular germ cell tumor; LUSC cis rs10791323 0.693 rs10750544 chr11:133718740 A/G cg15485101 chr11:133734466 NA 0.38 7.15 0.36 5.56e-12 Childhood ear infection; LUSC cis rs9814567 0.806 rs2888670 chr3:134326684 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.36 -0.56 3.81e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11676348 0.818 rs7426289 chr2:218966315 C/T cg06547715 chr2:218990976 CXCR2 0.33 6.34 0.33 7.44e-10 Ulcerative colitis; LUSC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg02896835 chr1:92012615 NA -0.65 -11.72 -0.54 8.22e-27 Breast cancer; LUSC cis rs6577655 0.517 rs6999469 chr8:135577530 G/A cg17885191 chr8:135476712 NA 0.59 7.62 0.38 2.61e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs72949976 0.898 rs6732233 chr2:214022834 C/T cg08319019 chr2:214017104 IKZF2 -0.57 -8.34 -0.42 1.93e-15 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs2354432 0.607 rs59689207 chr1:146722484 G/A cg25205988 chr1:146714368 CHD1L -1.0 -9.42 -0.46 7.81e-19 Mitochondrial DNA levels; LUSC cis rs7954584 0.635 rs7313252 chr12:122347600 G/A cg22618164 chr12:122356400 WDR66 0.58 8.57 0.42 3.94e-16 Mean corpuscular volume; LUSC cis rs447735 0.566 rs258337 chr16:89720710 T/A cg04240660 chr16:89714849 CHMP1A -0.4 -6.42 -0.33 4.6e-10 Hemoglobin concentration; LUSC cis rs9326248 0.581 rs10892061 chr11:116886114 C/T cg26566898 chr11:117069891 TAGLN 0.34 6.46 0.33 3.75e-10 Blood protein levels; LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg24060327 chr5:131705240 SLC22A5 0.69 11.35 0.53 1.86e-25 Breast cancer; LUSC trans rs7726839 0.540 rs12517638 chr5:645484 C/T cg11887960 chr12:57824829 NA 0.52 6.61 0.34 1.55e-10 Obesity-related traits; LUSC cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg21535247 chr6:8435926 SLC35B3 0.56 8.39 0.42 1.42e-15 Motion sickness; LUSC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg09365446 chr1:150670422 GOLPH3L 0.48 7.04 0.36 1.12e-11 Melanoma; LUSC cis rs61931739 1.000 rs12424741 chr12:34022771 C/T cg06521331 chr12:34319734 NA 0.4 6.7 0.34 8.72e-11 Morning vs. evening chronotype; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24788636 chr1:40562667 PPT1 0.36 6.18 0.32 1.87e-9 Triglycerides; LUSC cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg01579765 chr21:45077557 HSF2BP -0.46 -9.59 -0.46 2.06e-19 Mean corpuscular volume; LUSC cis rs7582180 0.627 rs2241811 chr2:101011724 C/T cg08017756 chr2:100939284 LONRF2 -0.43 -8.0 -0.4 2.04e-14 Intelligence (multi-trait analysis); LUSC cis rs10788972 0.620 rs34764952 chr1:54483694 C/T cg25741118 chr1:54482237 LDLRAD1 -0.3 -6.63 -0.34 1.32e-10 Parkinson disease and lewy body pathology; LUSC cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg12011299 chr4:100065546 ADH4 0.71 10.94 0.51 5.36e-24 Alcohol dependence; LUSC cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg21665744 chr7:39171113 POU6F2 0.44 6.68 0.34 9.83e-11 IgG glycosylation; LUSC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg09263875 chr16:632152 PIGQ 0.72 13.43 0.59 3.41e-33 Height; LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg03395511 chr6:291903 DUSP22 0.44 6.77 0.35 5.89e-11 Menopause (age at onset); LUSC cis rs9329221 0.905 rs17709397 chr8:10249861 G/A cg21775007 chr8:11205619 TDH -0.57 -8.37 -0.42 1.62e-15 Neuroticism; LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg05368731 chr17:41323189 NBR1 0.92 15.47 0.65 4.21e-41 Menopause (age at onset); LUSC cis rs6138458 1.000 rs227651 chr20:24929834 A/G cg26195577 chr20:24973756 C20orf3 1.13 18.17 0.71 8.33e-52 Blood protein levels; LUSC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg06022373 chr22:39101656 GTPBP1 0.78 12.08 0.55 3.89e-28 Menopause (age at onset); LUSC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg11845111 chr2:191398756 TMEM194B 0.54 9.31 0.45 1.71e-18 Pulse pressure; LUSC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg15485101 chr11:133734466 NA 0.42 7.69 0.39 1.71e-13 Childhood ear infection; LUSC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg00343986 chr7:65444356 GUSB -0.42 -6.28 -0.33 1.04e-9 Aortic root size; LUSC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.29 0.53 2.88e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs139156536 1 rs139156536 chr17:38164432 TTTTA/T cg17467752 chr17:38218738 THRA 0.49 7.19 0.37 4.17e-12 Lymphocyte percentage of white cells; LUSC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg13175981 chr1:150552382 MCL1 0.48 6.81 0.35 4.53e-11 Tonsillectomy; LUSC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg18230493 chr5:56204884 C5orf35 0.83 12.47 0.56 1.44e-29 Initial pursuit acceleration; LUSC cis rs367943 1.000 rs348958 chr5:112821137 G/A cg12552261 chr5:112820674 MCC -0.44 -6.99 -0.36 1.48e-11 Type 2 diabetes; LUSC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.41e-13 Bipolar disorder; LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.69 0.39 1.63e-13 Prudent dietary pattern; LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.0 -0.31 5.25e-9 Platelet count; LUSC cis rs782590 0.556 rs782579 chr2:55917604 A/G cg18811423 chr2:55921094 PNPT1 0.74 11.92 0.55 1.54e-27 Metabolic syndrome; LUSC cis rs1461503 0.534 rs4293127 chr11:122804263 G/C cg27398637 chr11:122830231 C11orf63 -0.38 -6.09 -0.32 3.16e-9 Menarche (age at onset); LUSC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg17328964 chr8:145687451 CYHR1 0.46 7.44 0.38 8.33e-13 Age at first birth; LUSC cis rs6469656 1.000 rs7820778 chr8:117666463 A/G cg24004040 chr8:117650383 NA -0.42 -6.26 -0.32 1.16e-9 Colorectal cancer; LUSC cis rs12681288 0.823 rs2701909 chr8:1003057 A/G cg15309053 chr8:964076 NA 0.34 6.98 0.36 1.62e-11 Schizophrenia; LUSC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.64e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg23205692 chr1:25664452 TMEM50A 0.42 6.44 0.33 4.21e-10 Erythrocyte sedimentation rate; LUSC cis rs2625529 0.557 rs1000281 chr15:72553422 A/G cg16672083 chr15:72433130 SENP8 0.45 7.63 0.39 2.47e-13 Red blood cell count; LUSC cis rs868036 0.634 rs8028313 chr15:68043057 C/G cg05925327 chr15:68127851 NA -0.39 -6.07 -0.32 3.39e-9 Restless legs syndrome; LUSC cis rs17270561 0.578 rs76182885 chr6:25904085 G/C cg17042849 chr6:26104293 HIST1H4C -0.57 -6.61 -0.34 1.57e-10 Iron status biomarkers; LUSC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg10523679 chr1:76189770 ACADM 0.86 14.08 0.61 1.19e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg27087555 chr16:88793112 FAM38A 1.23 12.51 0.56 1.05e-29 Plateletcrit; LUSC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.49 7.7 0.39 1.6e-13 Menarche (age at onset); LUSC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg06108461 chr20:60628389 TAF4 -1.01 -17.28 -0.69 2.91e-48 Body mass index; LUSC cis rs394563 0.967 rs444784 chr6:149798366 C/G cg07828024 chr6:149772892 ZC3H12D -0.32 -7.02 -0.36 1.25e-11 Dupuytren's disease; LUSC cis rs7769051 1.000 rs9493445 chr6:133125409 C/T cg22852734 chr6:133119734 C6orf192 1.17 14.03 0.61 1.8e-35 Type 2 diabetes nephropathy; LUSC cis rs4631830 0.733 rs4512771 chr10:51540906 C/A cg20129853 chr10:51489980 NA -0.33 -6.6 -0.34 1.63e-10 Prostate-specific antigen levels; LUSC cis rs6429082 0.714 rs184108 chr1:235646160 A/G cg26050004 chr1:235667680 B3GALNT2 0.61 8.33 0.41 2.06e-15 Adiposity; LUSC cis rs868036 0.681 rs1026737 chr15:68107072 A/C cg05925327 chr15:68127851 NA -0.41 -6.46 -0.33 3.79e-10 Restless legs syndrome; LUSC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.46 7.14 0.36 5.71e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs735396 0.694 rs2264750 chr12:121450165 C/T cg02403541 chr12:121454288 C12orf43 0.7 10.25 0.49 1.33e-21 N-glycan levels; LUSC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg05084668 chr3:125655381 ALG1L -0.48 -6.79 -0.35 5.17e-11 Blood pressure (smoking interaction); LUSC cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg02012338 chr4:187126139 CYP4V2 0.62 5.68 0.3 2.96e-8 Blood protein levels; LUSC cis rs847577 0.630 rs3801294 chr7:97822210 G/A cg21770322 chr7:97807741 LMTK2 0.56 10.08 0.48 4.99e-21 Breast cancer; LUSC cis rs12291225 0.839 rs4757244 chr11:14258655 A/G cg19336497 chr11:14380999 RRAS2 0.47 9.08 0.45 9.45e-18 Sense of smell; LUSC cis rs9921338 0.924 rs7202024 chr16:11440758 A/G cg00044050 chr16:11439710 C16orf75 -0.51 -6.68 -0.34 9.91e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs6960043 0.905 rs2215381 chr7:15054935 G/T cg19272540 chr7:15055459 NA 0.34 8.72 0.43 1.3e-16 Type 2 diabetes; LUSC cis rs9790314 0.846 rs1478568 chr3:161014276 C/T cg03342759 chr3:160939853 NMD3 -0.53 -9.02 -0.44 1.46e-17 Morning vs. evening chronotype; LUSC cis rs72781680 0.846 rs72780108 chr2:23986780 G/A cg20701182 chr2:24300061 SF3B14 0.56 6.09 0.32 3.06e-9 Lymphocyte counts; LUSC cis rs1953600 0.870 rs2573356 chr10:81949363 C/T cg00277334 chr10:82204260 NA 0.45 7.08 0.36 8.35e-12 Sarcoidosis; LUSC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.1e-30 Aortic root size; LUSC trans rs208520 0.690 rs207108 chr6:66794096 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg09039689 chr11:46639039 KIAA0652;HARBI1 0.43 6.34 0.33 7.6e-10 Triglycerides; LUSC cis rs240764 0.658 rs7753317 chr6:101220433 G/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.24 -0.32 1.29e-9 Neuroticism; LUSC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg19230755 chr7:65878503 NA -0.41 -5.81 -0.3 1.47e-8 Aortic root size; LUSC trans rs9291683 0.632 rs11734786 chr4:10041499 A/C cg26043149 chr18:55253948 FECH 0.49 7.24 0.37 3.14e-12 Bone mineral density; LUSC cis rs9928842 0.823 rs889514 chr16:75272512 A/G cg09066997 chr16:75300724 BCAR1 0.51 6.49 0.33 3.07e-10 Alcoholic chronic pancreatitis; LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg16606324 chr3:10149918 C3orf24 0.58 8.23 0.41 4.27e-15 Alzheimer's disease; LUSC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg23985595 chr17:80112537 CCDC57 0.3 5.82 0.3 1.39e-8 Life satisfaction; LUSC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg05738196 chr6:26577821 NA 0.53 8.33 0.41 2.14e-15 Schizophrenia; LUSC cis rs9905704 0.671 rs2531733 chr17:56548811 A/G cg12560992 chr17:57184187 TRIM37 -0.5 -5.7 -0.3 2.68e-8 Testicular germ cell tumor; LUSC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg13206674 chr6:150067644 NUP43 0.56 8.59 0.43 3.41e-16 Lung cancer; LUSC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg05855489 chr10:104503620 C10orf26 0.62 8.22 0.41 4.66e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34779708 0.966 rs12761675 chr10:35438337 C/T cg04310649 chr10:35416472 CREM 0.4 6.33 0.33 7.85e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7072216 0.726 rs4474372 chr10:100164571 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.9 -0.44 3.54e-17 Metabolite levels; LUSC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg14552801 chr7:65878734 NA 0.38 5.92 0.31 7.97e-9 Aortic root size; LUSC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg11632617 chr15:75315747 PPCDC -0.54 -7.1 -0.36 7.37e-12 Blood trace element (Zn levels); LUSC cis rs10782582 0.532 rs78106188 chr1:76137836 A/G cg22875332 chr1:76189707 ACADM -0.41 -6.21 -0.32 1.61e-9 Daytime sleep phenotypes; LUSC cis rs9341808 0.718 rs9443735 chr6:80820474 G/T cg08355045 chr6:80787529 NA 0.56 9.59 0.46 2.06e-19 Sitting height ratio; LUSC trans rs11148252 0.574 rs7139495 chr13:53283318 A/G cg18335740 chr13:41363409 SLC25A15 0.78 14.17 0.61 5.29e-36 Lewy body disease; LUSC cis rs1775715 1.000 rs1251363 chr10:32328526 G/C cg04359828 chr10:32216031 ARHGAP12 -0.36 -5.85 -0.31 1.14e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs765787 0.530 rs12904331 chr15:45518293 C/T cg25801113 chr15:45476975 SHF -0.34 -6.87 -0.35 3.13e-11 Uric acid levels; LUSC cis rs2629540 0.824 rs10901809 chr10:126410804 C/T cg08799069 chr10:126477246 METTL10 0.45 6.62 0.34 1.4e-10 Cocaine dependence; LUSC cis rs977987 1.000 rs62060550 chr16:75502252 C/T cg04384234 chr16:75411784 CFDP1 -0.49 -8.11 -0.41 9.52e-15 Dupuytren's disease; LUSC cis rs8141529 0.509 rs5762853 chr22:29245231 T/G cg15103426 chr22:29168792 CCDC117 0.48 6.2 0.32 1.66e-9 Lymphocyte counts; LUSC cis rs713477 1.000 rs713477 chr14:55904426 C/A cg04306507 chr14:55594613 LGALS3 -0.33 -6.47 -0.33 3.46e-10 Pediatric bone mineral content (femoral neck); LUSC trans rs80346118 0.850 rs73609692 chr20:47464324 G/A cg16950247 chr11:62911616 SLC22A24 0.49 5.96 0.31 6.47e-9 Diastolic blood pressure; LUSC cis rs2219968 1.000 rs59541962 chr8:78964111 G/C cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg03538708 chr1:25844672 NA -0.35 -5.74 -0.3 2.11e-8 Erythrocyte sedimentation rate; LUSC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg01802117 chr1:53393560 SCP2 0.38 6.23 0.32 1.37e-9 Monocyte count; LUSC cis rs1451375 0.572 rs68011952 chr7:50638128 C/T cg18232548 chr7:50535776 DDC 0.47 6.16 0.32 2.12e-9 Malaria; LUSC cis rs4073416 0.542 rs7147536 chr14:65874698 C/T cg03016385 chr14:66212404 NA -0.43 -6.9 -0.35 2.59e-11 N-glycan levels; LUSC trans rs6598955 0.671 rs12085416 chr1:26627835 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.66 -9.0 -0.44 1.77e-17 Obesity-related traits; LUSC cis rs2439831 0.681 rs7175434 chr15:43628542 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.93 10.83 0.51 1.25e-23 Lung cancer in ever smokers; LUSC cis rs7927592 0.913 rs12284933 chr11:68319489 G/A cg01657329 chr11:68192670 LRP5 -0.39 -5.67 -0.3 3.17e-8 Total body bone mineral density; LUSC cis rs9486715 0.867 rs9372106 chr6:96875058 T/C cg06623918 chr6:96969491 KIAA0776 0.93 17.19 0.69 6.65e-48 Headache; LUSC trans rs2587949 0.593 rs2587929 chr3:4238613 A/T cg15139668 chr4:4577005 NA -0.41 -6.13 -0.32 2.42e-9 Periodontitis (DPAL); LUSC trans rs2235573 0.551 rs139891 chr22:38387914 G/T cg19894588 chr14:64061835 NA 0.45 6.54 0.34 2.25e-10 Glioblastoma;Glioma; LUSC cis rs7208859 0.673 rs8077116 chr17:29140162 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg16489826 chr6:160211363 TCP1;MRPL18 -0.53 -6.93 -0.35 2.16e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs2820315 1.000 rs2820313 chr1:201870221 A/G cg10061532 chr1:201886748 LMOD1 0.27 6.25 0.32 1.28e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg25039879 chr17:56429692 SUPT4H1 -0.79 -11.15 -0.52 9.5e-25 Cognitive test performance; LUSC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg00484396 chr16:3507460 NAT15 -0.71 -12.38 -0.56 3.24e-29 Tuberculosis; LUSC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg25072359 chr17:41440525 NA 0.68 9.5 0.46 4.34e-19 Menopause (age at onset); LUSC cis rs6750047 0.585 rs4670234 chr2:38272477 C/T cg07380506 chr2:38303506 CYP1B1 0.45 6.26 0.32 1.2e-9 Cutaneous malignant melanoma;Melanoma; LUSC trans rs931812 0.557 rs4734498 chr8:101946548 T/G cg20993868 chr7:22813445 NA 0.34 6.28 0.32 1.07e-9 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs765787 0.530 rs28897155 chr15:45533974 T/C cg25801113 chr15:45476975 SHF 0.35 7.17 0.37 4.84e-12 Uric acid levels; LUSC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg17366294 chr4:99064904 C4orf37 0.57 9.91 0.48 1.88e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2180341 0.596 rs12215298 chr6:127676833 C/T cg27446573 chr6:127587934 RNF146 0.71 11.7 0.54 9.48e-27 Breast cancer; LUSC cis rs6952809 0.532 rs2023969 chr7:2449980 T/C cg23289794 chr7:2394357 EIF3B -0.75 -9.76 -0.47 5.75e-20 Multiple sclerosis; LUSC cis rs6138458 1.000 rs6138458 chr20:24973769 C/T cg26195577 chr20:24973756 C20orf3 1.1 18.4 0.71 1.05e-52 Blood protein levels; LUSC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg09263875 chr16:632152 PIGQ 0.71 12.79 0.57 9.63e-31 Height; LUSC cis rs12421382 0.690 rs2716049 chr11:109609889 A/C cg16359550 chr11:109292809 C11orf87 0.34 5.78 0.3 1.72e-8 Schizophrenia; LUSC cis rs295140 1.000 rs11696001 chr2:201162433 G/A cg04283868 chr2:201171347 SPATS2L 0.43 6.55 0.34 2.24e-10 QT interval; LUSC cis rs68170813 0.559 rs12534676 chr7:106943640 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.65 -0.3 3.5e-8 Coronary artery disease; LUSC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg21535942 chr1:75199100 CRYZ;TYW3 0.48 7.45 0.38 8.23e-13 Resistin levels; LUSC cis rs16976116 0.901 rs1061822 chr15:55496058 A/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs79349575 0.783 rs318096 chr17:46975370 G/A cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg13770153 chr20:60521292 NA -0.61 -8.41 -0.42 1.23e-15 Body mass index; LUSC cis rs28374715 0.662 rs111522288 chr15:41480169 C/T cg18705301 chr15:41695430 NDUFAF1 -0.86 -15.2 -0.64 4.98e-40 Ulcerative colitis; LUSC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg04369109 chr6:150039330 LATS1 -0.57 -8.45 -0.42 9.43e-16 Lung cancer; LUSC cis rs2290159 0.800 rs57884385 chr3:12673551 G/C cg23032965 chr3:12705835 RAF1 0.74 9.13 0.45 6.87e-18 Cholesterol, total; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19777900 chr20:56284917 PMEPA1 -0.41 -6.27 -0.32 1.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg06640241 chr16:89574553 SPG7 -0.71 -11.12 -0.52 1.18e-24 Multiple myeloma (IgH translocation); LUSC cis rs6815814 0.950 rs5743566 chr4:38805942 G/C cg02016764 chr4:38805732 TLR1 -0.53 -5.74 -0.3 2.16e-8 Breast cancer; LUSC cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg23029597 chr12:123009494 RSRC2 -0.74 -9.13 -0.45 6.67e-18 Body mass index; LUSC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg26818010 chr10:134567672 INPP5A -0.86 -11.15 -0.52 9.63e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs72634258 0.699 rs2493214 chr1:7994420 A/G cg26816564 chr1:7831052 VAMP3 0.48 6.72 0.34 8.02e-11 Inflammatory bowel disease; LUSC cis rs9467773 0.935 rs4573 chr6:26546808 A/G cg12292205 chr6:26970375 C6orf41 0.38 6.15 0.32 2.24e-9 Intelligence (multi-trait analysis); LUSC cis rs4704187 0.663 rs9654428 chr5:74466884 A/C cg03227963 chr5:74354835 NA 0.31 6.7 0.34 8.62e-11 Response to amphetamines; LUSC trans rs6598955 0.671 rs41285347 chr1:26644399 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.31 -0.41 2.44e-15 Obesity-related traits; LUSC cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg06552810 chr11:31128660 NA -0.4 -7.1 -0.36 7.62e-12 Red blood cell count; LUSC trans rs7680126 0.633 rs4698023 chr4:10304726 A/G cg26043149 chr18:55253948 FECH -0.49 -6.22 -0.32 1.45e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2398893 0.889 rs7870790 chr9:96779553 G/A cg14459158 chr9:96720562 NA 0.3 5.91 0.31 8.65e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg25802871 chr7:2282184 FTSJ2;NUDT1 -0.47 -6.0 -0.31 5.07e-9 Hepatitis; LUSC trans rs61931739 0.517 rs11052964 chr12:34010996 G/C cg26384229 chr12:38710491 ALG10B 0.72 11.08 0.52 1.6e-24 Morning vs. evening chronotype; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg14159672 chr1:205819179 PM20D1 0.85 15.51 0.65 2.99e-41 Menarche (age at onset); LUSC cis rs34779708 0.897 rs35784065 chr10:35353574 C/T cg03585969 chr10:35415529 CREM 0.58 8.43 0.42 1.02e-15 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg13072238 chr3:49761600 GMPPB -0.36 -5.8 -0.3 1.5e-8 Body mass index; LUSC cis rs2976388 1.000 rs2920294 chr8:143765326 C/G cg17252645 chr8:143867129 LY6D -0.37 -6.47 -0.33 3.51e-10 Urinary tract infection frequency; LUSC cis rs477692 0.699 rs578932 chr10:131370724 C/A cg26102564 chr10:131424627 MGMT 0.41 6.07 0.32 3.52e-9 Response to temozolomide; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg24060327 chr5:131705240 SLC22A5 -0.5 -7.92 -0.4 3.55e-14 Acylcarnitine levels; LUSC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg04944784 chr2:26401820 FAM59B 0.7 9.55 0.46 2.83e-19 Gut microbiome composition (summer); LUSC cis rs1949733 0.656 rs2688243 chr4:8436286 A/G cg13073564 chr4:8508604 NA -0.41 -7.98 -0.4 2.31e-14 Response to antineoplastic agents; LUSC cis rs2115630 0.967 rs11073731 chr15:85355113 C/A cg11189052 chr15:85197271 WDR73 -0.41 -5.91 -0.31 8.47e-9 P wave terminal force; LUSC cis rs78456975 0.943 rs10470006 chr2:1580971 A/C cg01028140 chr2:1542097 TPO -0.5 -6.94 -0.36 2.01e-11 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs8008758 0.517 rs1620117 chr14:101696931 C/A cg26224664 chr14:101693935 NA -0.38 -9.67 -0.47 1.14e-19 Body mass index (alcohol intake interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25099438 chr2:207024027 EEF1B2;NDUFS1 -0.38 -6.02 -0.31 4.71e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs68170813 0.559 rs3823960 chr7:107009349 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.56 -0.46 2.74e-19 Coronary artery disease; LUSC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg07806771 chr7:64541737 NA 0.42 5.98 0.31 5.6e-9 Calcium levels; LUSC cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg09658497 chr7:2847517 GNA12 -0.33 -5.9 -0.31 8.69e-9 Height; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg07092213 chr7:1199455 ZFAND2A -0.68 -11.25 -0.52 4.17e-25 Longevity;Endometriosis; LUSC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg18904891 chr8:8559673 CLDN23 0.41 6.03 0.31 4.32e-9 Mood instability; LUSC cis rs977987 0.778 rs4888426 chr16:75476451 G/A cg03315344 chr16:75512273 CHST6 0.49 9.5 0.46 4.32e-19 Dupuytren's disease; LUSC cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg15212455 chr7:39170539 POU6F2 0.59 9.47 0.46 5.27e-19 IgG glycosylation; LUSC cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg13319975 chr6:146136371 FBXO30 0.48 7.31 0.37 1.98e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg26441486 chr22:50317300 CRELD2 0.48 7.13 0.36 6.28e-12 Schizophrenia; LUSC cis rs9868809 0.505 rs11706983 chr3:48738678 A/G cg00383909 chr3:49044727 WDR6 1.14 10.58 0.5 9.36e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs9393777 0.623 rs2093169 chr6:26495099 C/T cg12826209 chr6:26865740 GUSBL1 0.69 7.79 0.39 8.74e-14 Intelligence (multi-trait analysis); LUSC cis rs6701037 1.000 rs6683533 chr1:175125440 G/A cg00321850 chr1:175162397 KIAA0040 -0.4 -6.9 -0.35 2.55e-11 Alcohol dependence; LUSC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg00814883 chr7:100076585 TSC22D4 -0.7 -8.67 -0.43 1.85e-16 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25405238 chr17:79254455 SLC38A10 0.44 6.02 0.31 4.72e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg04369109 chr6:150039330 LATS1 -0.55 -8.23 -0.41 4.32e-15 Lung cancer; LUSC cis rs7481584 0.624 rs80871 chr11:3049843 A/C cg08508325 chr11:3079039 CARS 0.38 8.51 0.42 6.01e-16 Calcium levels; LUSC cis rs1577917 0.958 rs1337843 chr6:86675545 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.24 -0.41 3.86e-15 Response to antipsychotic treatment; LUSC cis rs7799006 0.895 rs3757437 chr7:2271980 C/T cg08027265 chr7:2291960 NA -0.46 -7.82 -0.39 7.13e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg09267113 chr7:98030324 BAIAP2L1 0.38 5.78 0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg23791538 chr6:167370224 RNASET2 -0.4 -6.41 -0.33 4.9e-10 Crohn's disease; LUSC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg19257562 chr1:2043853 PRKCZ 0.32 6.32 0.33 8.45e-10 Height; LUSC cis rs225245 0.817 rs225269 chr17:33967931 G/T cg05299278 chr17:33885742 SLFN14 0.31 6.88 0.35 3.04e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs7726839 0.574 rs11134149 chr5:637277 A/G cg25482853 chr8:67687455 SGK3 1.06 15.78 0.65 2.71e-42 Obesity-related traits; LUSC cis rs13082711 0.863 rs35998108 chr3:27423427 G/A cg02860705 chr3:27208620 NA 0.49 8.38 0.42 1.53e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC trans rs17607347 0.542 rs62052891 chr16:72556434 C/T cg12945194 chr11:64703312 GPHA2 0.37 5.99 0.31 5.52e-9 Intelligence (multi-trait analysis); LUSC cis rs6460942 0.908 rs78682952 chr7:12284886 C/A cg06484146 chr7:12443880 VWDE -0.55 -5.85 -0.3 1.18e-8 Coronary artery disease; LUSC cis rs2576037 0.526 rs564113 chr18:44364389 A/T cg19077165 chr18:44547161 KATNAL2 -0.4 -5.99 -0.31 5.37e-9 Personality dimensions; LUSC cis rs6442522 0.733 rs4143273 chr3:15501808 C/T cg16303742 chr3:15540471 COLQ -0.3 -5.9 -0.31 8.68e-9 Uric acid levels; LUSC cis rs7954584 0.813 rs11043288 chr12:122451187 C/T cg21171335 chr12:122356390 WDR66 -0.52 -7.73 -0.39 1.31e-13 Mean corpuscular volume; LUSC cis rs4900538 0.928 rs1190551 chr14:102911508 A/G cg18135206 chr14:102964638 TECPR2 -1.04 -21.92 -0.77 1.28e-66 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs2739330 0.731 rs4822450 chr22:24242887 C/T cg06437703 chr8:37914619 EIF4EBP1 -0.61 -10.19 -0.49 2e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7582180 0.715 rs1866198 chr2:100917739 C/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.5 -0.42 6.45e-16 Intelligence (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg23493127 chr6:144164392 LTV1 -0.4 -7.1 -0.36 7.72e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1577917 0.727 rs9344539 chr6:86353621 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -7.04 -0.36 1.1e-11 Response to antipsychotic treatment; LUSC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4595586 0.545 rs3911798 chr12:39389901 A/G cg13010199 chr12:38710504 ALG10B 0.41 6.02 0.31 4.71e-9 Morning vs. evening chronotype; LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg21745248 chr20:55926117 RAE1 0.72 6.69 0.34 9.41e-11 Myocardial infarction; LUSC trans rs12210905 0.688 rs114157955 chr6:27329878 C/T cg02699829 chr19:13216355 TRMT1 -0.56 -6.23 -0.32 1.39e-9 Hip circumference adjusted for BMI; LUSC trans rs747782 0.528 rs11039669 chr11:48328818 C/T cg03929089 chr4:120376271 NA 0.66 6.22 0.32 1.47e-9 Intraocular pressure; LUSC cis rs28493229 0.522 rs2233152 chr19:41281016 C/T cg21869046 chr19:41225005 ITPKC 0.49 6.78 0.35 5.56e-11 Kawasaki disease; LUSC cis rs709400 0.628 rs12889639 chr14:103860206 G/A cg10523860 chr14:103875565 MARK3 0.41 6.81 0.35 4.52e-11 Body mass index; LUSC cis rs9814567 0.806 rs4245904 chr3:134321808 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.33 -0.56 4.74e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg23788917 chr6:8435910 SLC35B3 0.5 7.52 0.38 5.17e-13 Motion sickness; LUSC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg04455712 chr21:45112962 RRP1B 0.46 8.79 0.43 8.25e-17 Mean corpuscular volume; LUSC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.39 -7.85 -0.39 5.8e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs7789940 1.000 rs758944 chr7:75953297 G/T cg10167463 chr7:75959203 YWHAG -0.64 -9.64 -0.47 1.45e-19 Multiple sclerosis; LUSC cis rs7795096 0.806 rs1109277 chr7:151540959 C/G cg17008978 chr7:151542804 PRKAG2 -0.34 -6.58 -0.34 1.8e-10 Bipolar disorder (age of onset and psychotic symptoms); LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg09877947 chr5:131593287 PDLIM4 0.44 6.68 0.34 1.03e-10 Breast cancer; LUSC cis rs79387448 0.683 rs7571985 chr2:103147561 G/A cg09003973 chr2:102972529 NA 0.88 8.61 0.43 2.99e-16 Gut microbiota (bacterial taxa); LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg14433983 chr11:636460 DRD4 -0.35 -5.88 -0.31 9.78e-9 Systemic lupus erythematosus; LUSC cis rs12464483 0.524 rs4952173 chr2:30888346 G/T cg12454169 chr2:30669597 LCLAT1 0.62 8.45 0.42 9.14e-16 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs72781680 0.898 rs112985192 chr2:24102797 G/A cg08917208 chr2:24149416 ATAD2B 0.88 10.02 0.48 7.83e-21 Lymphocyte counts; LUSC cis rs11098499 0.863 rs1480936 chr4:120462861 C/T cg09307838 chr4:120376055 NA 0.75 10.7 0.51 3.49e-23 Corneal astigmatism; LUSC cis rs1448094 0.967 rs7978132 chr12:86323484 T/C cg18827107 chr12:86230957 RASSF9 -0.4 -5.95 -0.31 6.77e-9 Major depressive disorder; LUSC trans rs61931739 0.929 rs3912551 chr12:34076696 C/T cg26384229 chr12:38710491 ALG10B -0.59 -9.58 -0.46 2.35e-19 Morning vs. evening chronotype; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -6.25 -0.32 1.22e-9 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg16240275 chr20:61666158 NCRNA00029 0.42 8.89 0.44 3.82e-17 Prostate cancer (SNP x SNP interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27110648 chr12:100378843 ANKS1B 0.39 5.94 0.31 7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.84 -0.54 3.05e-27 Chronic sinus infection; LUSC cis rs12579753 0.956 rs11115038 chr12:82214660 T/G cg21231944 chr12:82153410 PPFIA2 -0.39 -5.89 -0.31 9.34e-9 Resting heart rate; LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.65 -0.34 1.2e-10 Menopause (age at onset); LUSC cis rs7089973 0.872 rs7094072 chr10:116627160 T/G cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 5.96e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9660992 0.789 rs1768584 chr1:205240145 A/G cg21643547 chr1:205240462 TMCC2 -0.51 -9.98 -0.48 1.09e-20 Mean corpuscular volume;Mean platelet volume; LUSC trans rs72674100 1.000 rs28417914 chr4:97988227 G/T cg16405019 chr1:18959625 PAX7 -0.58 -6.33 -0.33 7.76e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -7.03 -0.36 1.14e-11 Mean platelet volume; LUSC cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg12011299 chr4:100065546 ADH4 0.71 11.1 0.52 1.44e-24 Alcohol dependence; LUSC cis rs968451 0.865 rs12627761 chr22:39724137 A/G cg17798944 chr22:39715225 SNORD43;RPL3 -0.63 -8.52 -0.42 5.65e-16 Primary biliary cholangitis; LUSC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs12549902 0.897 rs12549294 chr8:41506380 A/G cg21772509 chr8:41503840 NKX6-3 0.69 11.49 0.53 5.84e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs757278 0.591 rs4727855 chr7:117305374 A/G cg10524701 chr7:117356490 CTTNBP2 -0.4 -5.74 -0.3 2.11e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg11764359 chr7:65958608 NA 0.7 10.7 0.51 3.47e-23 Aortic root size; LUSC cis rs7937682 0.883 rs1612013 chr11:111456293 A/G cg22437258 chr11:111473054 SIK2 0.51 7.05 0.36 1e-11 Primary sclerosing cholangitis; LUSC cis rs11031096 0.754 rs10835611 chr11:4117730 G/C cg18678763 chr11:4115507 RRM1 -0.48 -7.1 -0.36 7.72e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6469656 0.730 rs1436766 chr8:117652598 T/C cg24004040 chr8:117650383 NA -0.45 -6.46 -0.33 3.68e-10 Colorectal cancer; LUSC cis rs9650657 0.615 rs7818181 chr8:10696515 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.29 -0.33 1.01e-9 Neuroticism; LUSC cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg23788917 chr6:8435910 SLC35B3 0.5 7.33 0.37 1.8e-12 Motion sickness; LUSC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg05535760 chr7:792225 HEATR2 0.78 9.17 0.45 5.01e-18 Cerebrospinal P-tau181p levels; LUSC cis rs6692729 0.966 rs8383 chr1:227083550 C/T cg10327440 chr1:227177885 CDC42BPA -0.5 -7.06 -0.36 9.96e-12 Electrodermal activity; LUSC cis rs4919694 1.000 rs12261040 chr10:104665397 T/C cg23093090 chr10:104574429 C10orf26 -0.46 -5.74 -0.3 2.12e-8 Arsenic metabolism; LUSC cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg05347473 chr6:146136440 FBXO30 -0.47 -7.8 -0.39 8.16e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs4903214 0.895 rs7161419 chr14:74695757 A/G cg17626009 chr17:80792113 TBCD;ZNF750 -0.46 -6.31 -0.33 8.77e-10 Inflammatory bowel disease; LUSC cis rs11048434 0.736 rs34798934 chr12:9108444 C/T cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC cis rs7580658 0.857 rs11890187 chr2:128083738 T/C cg09760422 chr2:128146352 NA -0.3 -6.47 -0.33 3.52e-10 Protein C levels; LUSC cis rs9467773 1.000 rs4871 chr6:26545632 G/A cg05738196 chr6:26577821 NA 0.81 15.89 0.66 9.93e-43 Intelligence (multi-trait analysis); LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg24675658 chr1:53192096 ZYG11B -0.68 -11.29 -0.53 2.95e-25 Monocyte count; LUSC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg00522288 chr12:125625016 AACS -0.33 -5.99 -0.31 5.47e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.34 0.62 1.16e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.55 -0.53 3.51e-26 Schizophrenia; LUSC cis rs60843830 0.596 rs17041320 chr2:112051 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.43 6.5 0.33 2.98e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs59698941 0.943 rs67806898 chr5:132296771 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs9325144 0.532 rs12812406 chr12:38719802 G/A cg26384229 chr12:38710491 ALG10B -0.59 -9.14 -0.45 6.19e-18 Morning vs. evening chronotype; LUSC cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.79 0.39 8.41e-14 Height; LUSC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg09455208 chr3:40491958 NA 0.58 10.27 0.49 1.07e-21 Renal cell carcinoma; LUSC trans rs3733585 0.577 rs5014939 chr4:9953253 T/A cg26043149 chr18:55253948 FECH -0.45 -6.9 -0.35 2.59e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4561483 0.514 rs33639 chr16:11989499 A/C cg08843971 chr16:11963173 GSPT1 -0.44 -6.63 -0.34 1.33e-10 Testicular germ cell tumor; LUSC cis rs7809950 0.678 rs6949634 chr7:106984684 G/T cg23024343 chr7:107201750 COG5 -0.64 -9.59 -0.46 2.06e-19 Coronary artery disease; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs11711311 0.955 rs2124105 chr3:113406003 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.1 0.32 2.92e-9 IgG glycosylation; LUSC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs240764 0.658 rs9322182 chr6:101223295 G/A cg09795085 chr6:101329169 ASCC3 -0.45 -6.34 -0.33 7.43e-10 Neuroticism; LUSC cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg23711669 chr6:146136114 FBXO30 -0.92 -17.89 -0.7 1.18e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs11711311 1.000 rs11719303 chr3:113494524 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -6.03 -0.31 4.39e-9 IgG glycosylation; LUSC cis rs7705502 1.000 rs7705507 chr5:173358337 C/T cg18693985 chr5:173351052 CPEB4 -0.37 -5.79 -0.3 1.65e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1044826 0.597 rs6772199 chr3:139178133 C/T cg15131784 chr3:139108705 COPB2 0.4 6.48 0.33 3.24e-10 Obesity-related traits; LUSC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs7582720 1.000 rs72934519 chr2:203939640 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs77106637 1.000 rs11602858 chr11:72615069 C/G cg03713592 chr11:72463424 ARAP1 0.82 9.59 0.46 2.19e-19 Type 2 diabetes; LUSC cis rs6121246 0.529 rs6060142 chr20:30178028 A/G cg13852791 chr20:30311386 BCL2L1 0.7 8.01 0.4 1.97e-14 Mean corpuscular hemoglobin; LUSC cis rs17095355 0.642 rs57822924 chr10:111702078 G/A cg00817464 chr10:111662876 XPNPEP1 -0.62 -7.61 -0.38 2.8e-13 Biliary atresia; LUSC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg25019033 chr10:957182 NA -0.5 -6.26 -0.32 1.18e-9 Eosinophil percentage of granulocytes; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg02475777 chr4:1388615 CRIPAK 0.39 5.77 0.3 1.8e-8 Obesity-related traits; LUSC cis rs12148488 0.966 rs1867148 chr15:75339985 T/C cg14664628 chr15:75095509 CSK 0.43 6.16 0.32 2.11e-9 Caffeine consumption; LUSC trans rs1325195 0.881 rs2816208 chr1:179171248 G/A cg11624085 chr17:8464688 MYH10 0.41 6.64 0.34 1.29e-10 IgE grass sensitization; LUSC cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg23711669 chr6:146136114 FBXO30 0.81 14.55 0.62 1.77e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs2996428 0.561 rs2275833 chr1:3745721 C/T cg23277830 chr1:3704460 LRRC47 0.31 5.87 0.31 1.05e-8 Red cell distribution width; LUSC cis rs7512552 0.839 rs1097070 chr1:150332955 A/T cg15654264 chr1:150340011 RPRD2 0.64 10.58 0.5 9.37e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9430161 0.611 rs35033941 chr1:11034382 C/T cg02454025 chr1:11042201 C1orf127 1.03 18.59 0.71 1.77e-53 Ewing sarcoma; LUSC cis rs17401966 0.931 rs2185252 chr1:10415912 T/C cg19773385 chr1:10388646 KIF1B -0.58 -9.93 -0.48 1.59e-20 Hepatocellular carcinoma; LUSC cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg06582575 chr6:163149167 PACRG;PARK2 1.1 14.12 0.61 7.99e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17401966 1.000 rs11121532 chr1:10277898 G/T cg19773385 chr1:10388646 KIF1B -0.54 -8.31 -0.41 2.52e-15 Hepatocellular carcinoma; LUSC cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg10518543 chr12:38710700 ALG10B 0.4 5.71 0.3 2.44e-8 Morning vs. evening chronotype; LUSC cis rs2294693 0.945 rs9394755 chr6:41006680 C/T cg14769373 chr6:40998127 UNC5CL 0.5 7.11 0.36 7.17e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs2742417 0.967 rs1609553 chr3:45735142 T/C cg09608765 chr3:45636137 LIMD1 -0.38 -7.38 -0.37 1.24e-12 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs62458065 0.513 rs10268803 chr7:32547835 A/G cg00845942 chr12:64062724 DPY19L2 -0.61 -7.62 -0.38 2.63e-13 Metabolite levels (HVA/MHPG ratio); LUSC trans rs4729127 1.000 rs73426361 chr7:94012656 G/T cg20086523 chr13:52378287 DHRS12 0.55 6.41 0.33 5.07e-10 Intelligence; LUSC cis rs7760535 0.811 rs464401 chr6:111669007 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Metabolic traits; LUSC cis rs739401 0.572 rs389285 chr11:3062673 G/A cg25174290 chr11:3078921 CARS 0.59 9.14 0.45 6.32e-18 Longevity; LUSC cis rs7769051 0.521 rs9321367 chr6:133084359 G/T cg07930552 chr6:133119739 C6orf192 0.71 6.89 0.35 2.76e-11 Type 2 diabetes nephropathy; LUSC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg06637938 chr14:75390232 RPS6KL1 0.53 8.29 0.41 2.73e-15 Height; LUSC cis rs1385374 0.642 rs10847691 chr12:129287449 G/A cg09035930 chr12:129282057 SLC15A4 -0.63 -6.85 -0.35 3.63e-11 Systemic lupus erythematosus; LUSC cis rs28735056 1.000 rs28735056 chr18:77622879 A/G cg20368463 chr18:77673604 PQLC1 -0.53 -7.7 -0.39 1.58e-13 Schizophrenia; LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.21 -0.37 3.86e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg24675658 chr1:53192096 ZYG11B 0.58 9.14 0.45 6.02e-18 Monocyte count; LUSC cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg22117172 chr7:91764530 CYP51A1 0.32 5.68 0.3 2.9e-8 Breast cancer; LUSC cis rs3087591 0.922 rs12950506 chr17:29598392 A/G cg24425628 chr17:29625626 OMG;NF1 0.54 7.72 0.39 1.4e-13 Hip circumference; LUSC cis rs1577917 1.000 rs10455455 chr6:86670214 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.73 -0.43 1.23e-16 Response to antipsychotic treatment; LUSC trans rs9929218 1.000 rs12448448 chr16:68802516 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.48 -0.53 6.2e-26 Colorectal cancer; LUSC cis rs28647808 0.881 rs41316984 chr9:136259231 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs12421382 0.811 rs11602639 chr11:109472829 C/T cg27471124 chr11:109292789 C11orf87 0.45 7.71 0.39 1.5e-13 Schizophrenia; LUSC cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.06 -0.4 1.41e-14 Personality dimensions; LUSC trans rs12200782 1.000 rs12199239 chr6:26432570 G/C cg11837749 chr1:55047332 ACOT11 0.58 6.23 0.32 1.41e-9 Small cell lung carcinoma; LUSC cis rs992157 0.798 rs2382817 chr2:219151218 A/C cg20019365 chr2:219134978 PNKD;AAMP 0.46 7.02 0.36 1.23e-11 Colorectal cancer; LUSC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs4780401 0.573 rs8045673 chr16:11804385 C/A cg01061890 chr16:11836724 TXNDC11 -0.55 -8.33 -0.41 2.15e-15 Rheumatoid arthritis; LUSC cis rs7980687 0.628 rs2102949 chr12:123676763 G/A cg13010344 chr12:123464640 ARL6IP4 -0.48 -7.21 -0.37 3.65e-12 Height;Educational attainment;Head circumference (infant); LUSC cis rs4663866 1.000 rs4663866 chr2:239150815 A/C cg16914508 chr2:239161102 PER2 0.65 6.88 0.35 3.03e-11 Irritable bowel syndrome; LUSC cis rs7113850 0.512 rs11027747 chr11:24197995 A/G ch.11.24196551F chr11:24239977 NA -0.55 -5.93 -0.31 7.49e-9 Bone fracture in osteoporosis; LUSC cis rs8028313 0.630 rs12438118 chr15:67951150 A/C cg05925327 chr15:68127851 NA 0.43 6.8 0.35 4.8e-11 Obesity; LUSC cis rs1348850 0.632 rs12471621 chr2:178502353 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.07 0.32 3.49e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg16586182 chr3:47516702 SCAP -0.49 -7.71 -0.39 1.47e-13 Colorectal cancer; LUSC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg24585782 chr17:78113791 EIF4A3 0.53 7.83 0.39 6.45e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs911119 0.913 rs3810575 chr20:23583392 G/A cg16589663 chr20:23618590 CST3 0.62 7.53 0.38 4.7e-13 Chronic kidney disease; LUSC cis rs62400317 0.762 rs10456120 chr6:44900107 C/T cg18551225 chr6:44695536 NA -0.48 -7.85 -0.39 5.89e-14 Total body bone mineral density; LUSC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.65 0.54 1.53e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7572733 0.534 rs11899188 chr2:198740121 C/T cg00792783 chr2:198669748 PLCL1 0.45 5.99 0.31 5.43e-9 Dermatomyositis; LUSC cis rs34779708 0.931 rs4934533 chr10:35359619 A/G cg03585969 chr10:35415529 CREM 0.6 8.8 0.43 7.41e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg22968622 chr17:43663579 NA -0.77 -11.79 -0.54 4.49e-27 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1371867 0.846 rs1660329 chr8:101304048 G/T cg00191853 chr8:101177733 SPAG1 -0.41 -6.56 -0.34 2.08e-10 Atrioventricular conduction; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.4e-14 Prudent dietary pattern; LUSC cis rs7760949 0.889 rs9396264 chr6:13930342 T/A cg27413430 chr6:13925136 RNF182 0.61 8.97 0.44 2.17e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg14004847 chr7:1930337 MAD1L1 -0.55 -8.26 -0.41 3.33e-15 Bipolar disorder and schizophrenia; LUSC trans rs2055729 0.710 rs10104236 chr8:9740292 G/C cg06636001 chr8:8085503 FLJ10661 -0.46 -5.96 -0.31 6.25e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs9807989 0.839 rs1974675 chr2:102986375 G/A cg09003973 chr2:102972529 NA 0.44 6.0 0.31 5.06e-9 Asthma; LUSC cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -7.46 -0.38 7.33e-13 Chronic sinus infection; LUSC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg04317338 chr11:64019027 PLCB3 0.66 7.53 0.38 4.65e-13 Mean platelet volume; LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.79 0.43 8.13e-17 Prudent dietary pattern; LUSC cis rs7824557 0.628 rs34237267 chr8:11197301 G/C cg21293242 chr8:11204541 TDH 0.31 5.75 0.3 2.04e-8 Retinal vascular caliber; LUSC cis rs9457247 1.000 rs422094 chr6:167397033 C/G cg20406979 chr6:167373233 NA 0.26 6.12 0.32 2.68e-9 Crohn's disease; LUSC cis rs616402 0.527 rs11584327 chr1:10578791 T/C cg17425144 chr1:10567563 PEX14 0.64 13.28 0.59 1.27e-32 Breast size; LUSC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg19748678 chr4:122722346 EXOSC9 0.5 7.54 0.38 4.37e-13 Type 2 diabetes; LUSC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg18306943 chr3:40428807 ENTPD3 0.38 5.82 0.3 1.36e-8 Renal cell carcinoma; LUSC cis rs9790314 0.663 rs7630674 chr3:160813597 G/A cg03342759 chr3:160939853 NMD3 -0.39 -6.41 -0.33 4.89e-10 Morning vs. evening chronotype; LUSC cis rs782590 0.967 rs17278044 chr2:55748217 G/C cg18811423 chr2:55921094 PNPT1 0.82 14.35 0.62 1.04e-36 Metabolic syndrome; LUSC cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg23649088 chr2:200775458 C2orf69 0.6 7.4 0.38 1.08e-12 Schizophrenia; LUSC cis rs3931020 0.657 rs7522428 chr1:75178360 C/T cg00121533 chr1:75199117 CRYZ;TYW3 0.46 5.83 0.3 1.31e-8 Resistin levels; LUSC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18404041 chr3:52824283 ITIH1 -0.52 -10.19 -0.49 2.09e-21 Bipolar disorder; LUSC cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg23158103 chr7:148848205 ZNF398 -0.46 -7.56 -0.38 3.84e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7020830 0.894 rs12337316 chr9:37148105 G/A cg14294708 chr9:37120828 ZCCHC7 1.06 23.43 0.79 1.74e-72 Schizophrenia; LUSC cis rs6088580 0.524 rs6088552 chr20:33226491 A/G cg07148914 chr20:33460835 GGT7 -0.51 -7.94 -0.4 3.09e-14 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -5.91 -0.31 8.63e-9 Developmental language disorder (linguistic errors); LUSC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14548871 chr10:102505330 PAX2 -0.46 -6.26 -0.32 1.21e-9 Hepatitis; LUSC cis rs8141529 0.732 rs6005872 chr22:29172898 T/G cg02153584 chr22:29168773 CCDC117 0.68 10.95 0.51 4.85e-24 Lymphocyte counts; LUSC cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg04362960 chr10:104952993 NT5C2 0.55 8.01 0.4 1.91e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg23711669 chr6:146136114 FBXO30 -0.89 -16.79 -0.68 2.56e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg00012203 chr2:219082015 ARPC2 -0.87 -16.56 -0.67 2.12e-45 Colorectal cancer; LUSC cis rs28374715 0.662 rs13329579 chr15:41467435 C/T cg18705301 chr15:41695430 NDUFAF1 -0.85 -14.98 -0.63 3.53e-39 Ulcerative colitis; LUSC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.1e-16 Aortic root size; LUSC cis rs9486719 1.000 rs4343922 chr6:96876903 C/T cg06623918 chr6:96969491 KIAA0776 0.77 9.79 0.47 4.6e-20 Migraine;Coronary artery disease; LUSC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11890956 chr21:40555474 PSMG1 1.02 20.48 0.75 5.84e-61 Cognitive function; LUSC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -6.41 -0.33 4.89e-10 Developmental language disorder (linguistic errors); LUSC cis rs3540 0.597 rs12708583 chr15:91050271 C/T cg10434728 chr15:90938212 IQGAP1 0.39 8.2 0.41 5.23e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs763121 0.853 rs4820345 chr22:39091151 T/C cg14440974 chr22:39074834 NA -0.39 -6.45 -0.33 3.82e-10 Menopause (age at onset); LUSC cis rs738321 0.701 rs11703601 chr22:38598041 C/T cg25457927 chr22:38595422 NA -0.45 -8.44 -0.42 1.01e-15 Breast cancer; LUSC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18404041 chr3:52824283 ITIH1 0.47 8.91 0.44 3.34e-17 Bipolar disorder; LUSC cis rs599083 0.744 rs603129 chr11:68186669 A/T cg01657329 chr11:68192670 LRP5 0.51 7.57 0.38 3.73e-13 Bone mineral density (spine); LUSC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.59 0.46 2.2e-19 Mean platelet volume; LUSC cis rs9549260 0.561 rs2297014 chr13:41372960 G/A cg21288729 chr13:41239152 FOXO1 0.53 5.85 0.3 1.16e-8 Red blood cell count; LUSC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -10.06 -0.48 5.49e-21 Developmental language disorder (linguistic errors); LUSC cis rs10782582 0.609 rs76260657 chr1:76338017 C/T cg10523679 chr1:76189770 ACADM -0.46 -6.53 -0.34 2.38e-10 Daytime sleep phenotypes; LUSC cis rs239198 0.602 rs9377240 chr6:101323752 C/T cg09795085 chr6:101329169 ASCC3 0.45 6.35 0.33 6.95e-10 Menarche (age at onset); LUSC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs7647973 0.593 rs4855885 chr3:49690199 G/A cg21659725 chr3:3221576 CRBN -0.68 -7.65 -0.39 2.13e-13 Menarche (age at onset); LUSC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg07777115 chr5:623756 CEP72 -0.45 -5.7 -0.3 2.62e-8 Obesity-related traits; LUSC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg23791538 chr6:167370224 RNASET2 0.41 6.7 0.34 8.84e-11 Crohn's disease; LUSC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg13902645 chr11:5959945 NA -0.58 -8.27 -0.41 3.14e-15 DNA methylation (variation); LUSC cis rs2952156 0.959 rs1495102 chr17:37832093 T/C cg00129232 chr17:37814104 STARD3 -0.43 -6.25 -0.32 1.26e-9 Asthma; LUSC cis rs3892630 0.500 rs6510301 chr19:33359791 A/T cg22980127 chr19:33182716 NUDT19 0.69 8.82 0.43 6.3e-17 Red blood cell traits; LUSC trans rs61931739 0.500 rs7306053 chr12:34510848 T/G cg13010199 chr12:38710504 ALG10B 0.57 9.09 0.45 9.21e-18 Morning vs. evening chronotype; LUSC cis rs9905704 0.624 rs11652761 chr17:56986095 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.36 -0.37 1.45e-12 Testicular germ cell tumor; LUSC cis rs9420 0.884 rs589914 chr11:57661032 A/G cg02958346 chr11:57425731 CLP1 0.44 6.04 0.31 4.07e-9 Schizophrenia; LUSC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg18512352 chr11:47633146 NA -0.48 -9.8 -0.47 4.44e-20 Subjective well-being; LUSC cis rs10493773 0.532 rs12064199 chr1:86187073 A/T cg17807903 chr1:86174739 ZNHIT6 -0.52 -13.94 -0.61 4.06e-35 Urate levels in overweight individuals; LUSC cis rs9837602 1.000 rs2291494 chr3:99781805 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.82 -0.3 1.38e-8 Breast cancer; LUSC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 6.03 0.31 4.44e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.57 11.42 0.53 9.72e-26 Monocyte percentage of white cells; LUSC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg11645453 chr3:52864694 ITIH4 -0.36 -8.3 -0.41 2.64e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg04871131 chr7:94954202 PON1 -0.39 -6.18 -0.32 1.84e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg20406979 chr6:167373233 NA -0.26 -6.11 -0.32 2.77e-9 Crohn's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00978910 chr1:172502140 C1orf9 -0.49 -6.17 -0.32 2e-9 Bipolar disorder and schizophrenia; LUSC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg09365446 chr1:150670422 GOLPH3L -0.44 -6.72 -0.35 7.86e-11 Tonsillectomy; LUSC cis rs3008870 0.755 rs2815366 chr1:67499930 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.54 0.57 8.04e-30 Lymphocyte percentage of white cells; LUSC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg14949292 chr17:78079608 GAA 0.4 6.89 0.35 2.79e-11 Yeast infection; LUSC cis rs12760731 0.565 rs11583503 chr1:178169663 G/C cg00404053 chr1:178313656 RASAL2 0.66 6.82 0.35 4.26e-11 Obesity-related traits; LUSC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.47e-8 Life satisfaction; LUSC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg24147428 chr11:65409760 SIPA1 -0.52 -7.73 -0.39 1.25e-13 Blood pressure (age interaction); LUSC cis rs1018836 0.851 rs12548741 chr8:91628878 G/A cg16814680 chr8:91681699 NA -0.77 -12.99 -0.58 1.66e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs908922 0.676 rs491077 chr1:152519570 C/A cg20991723 chr1:152506922 NA 0.5 9.28 0.45 2.18e-18 Hair morphology; LUSC cis rs1030877 0.515 rs920217 chr2:105904662 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.66 -9.25 -0.45 2.65e-18 Obesity-related traits; LUSC cis rs68170813 0.523 rs10253172 chr7:106786474 C/T cg02696742 chr7:106810147 HBP1 0.65 9.18 0.45 4.72e-18 Coronary artery disease; LUSC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg25173405 chr17:45401733 C17orf57 -0.39 -6.19 -0.32 1.74e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg22920501 chr2:26401640 FAM59B -0.67 -8.85 -0.44 5.39e-17 Gut microbiome composition (summer); LUSC cis rs3020736 0.500 rs6002604 chr22:42493081 A/T cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9902453 0.967 rs4994355 chr17:28386284 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.74 -0.43 1.19e-16 Coffee consumption (cups per day); LUSC trans rs853679 0.546 rs200948 chr6:27835272 T/C cg01620082 chr3:125678407 NA -0.75 -7.26 -0.37 2.81e-12 Depression; LUSC cis rs7582180 0.903 rs13013891 chr2:100896110 T/C cg08017756 chr2:100939284 LONRF2 -0.36 -5.97 -0.31 5.98e-9 Intelligence (multi-trait analysis); LUSC cis rs1997103 1.000 rs4947499 chr7:55407196 T/C cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs60843830 1.000 rs2126129 chr2:212548 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 10.33 0.49 7.1e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4363385 0.776 rs1415957 chr1:152948909 A/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.41 -0.38 1.03e-12 Inflammatory skin disease; LUSC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.43 -0.69 7.53e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7927592 0.913 rs10896338 chr11:68299360 G/A cg20283391 chr11:68216788 NA -0.61 -8.57 -0.42 3.81e-16 Total body bone mineral density; LUSC cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg08807101 chr21:30365312 RNF160 -0.72 -12.81 -0.57 7.8e-31 Dental caries; LUSC cis rs12995849 0.676 rs934306 chr2:106459654 C/A cg14210321 chr2:106509881 NCK2 -0.41 -5.94 -0.31 7.02e-9 Addiction; LUSC cis rs1018836 0.892 rs4140680 chr8:91584157 G/A cg16814680 chr8:91681699 NA -0.65 -9.81 -0.47 3.95e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs12911832 1.000 rs12911832 chr15:58985904 A/T cg05156742 chr15:59063176 FAM63B 0.47 6.6 0.34 1.58e-10 Schizophrenia; LUSC cis rs9329289 0.510 rs9733402 chr10:2551532 G/A cg15501526 chr10:2543763 NA 0.56 9.88 0.48 2.33e-20 Age-related hearing impairment; LUSC cis rs7246657 0.882 rs8112610 chr19:37928730 C/A cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs4363385 0.510 rs7532166 chr1:153046851 C/G cg25856811 chr1:152973957 SPRR3 -0.37 -6.11 -0.32 2.78e-9 Inflammatory skin disease; LUSC cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg26597838 chr10:835615 NA 0.88 11.69 0.54 1.09e-26 Eosinophil percentage of granulocytes; LUSC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg24881330 chr22:46731750 TRMU 0.91 7.17 0.37 4.85e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs1005277 0.505 rs200931 chr10:38128434 A/C cg25427524 chr10:38739819 LOC399744 -0.65 -11.4 -0.53 1.19e-25 Extrinsic epigenetic age acceleration; LUSC cis rs9814567 1.000 rs1874883 chr3:134205071 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.85 -14.37 -0.62 8.64e-37 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.16 -0.41 6.92e-15 Lung cancer; LUSC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg01420254 chr6:26195488 NA 0.72 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg01475377 chr6:109611718 NA 0.42 7.51 0.38 5.35e-13 Reticulocyte fraction of red cells; LUSC cis rs4631830 0.720 rs4935573 chr10:51504385 A/G cg20129853 chr10:51489980 NA 0.36 7.45 0.38 7.84e-13 Prostate-specific antigen levels; LUSC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg12463550 chr7:65579703 CRCP 0.56 8.35 0.42 1.79e-15 Aortic root size; LUSC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.51 0.34 2.83e-10 Lung cancer; LUSC cis rs2046867 0.862 rs62251657 chr3:72832076 C/T cg25664220 chr3:72788482 NA -0.72 -12.01 -0.55 7.08e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9399401 0.845 rs263189 chr6:142859724 T/C cg03128060 chr6:142623767 GPR126 0.32 5.96 0.31 6.54e-9 Chronic obstructive pulmonary disease; LUSC cis rs11971779 0.680 rs7805824 chr7:139111169 C/G cg23387468 chr7:139079360 LUC7L2 -0.42 -6.44 -0.33 4.05e-10 Diisocyanate-induced asthma; LUSC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg18252515 chr7:66147081 NA 1.22 13.64 0.6 5.53e-34 Diabetic kidney disease; LUSC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -10.7 -0.51 3.49e-23 Schizophrenia; LUSC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg03806693 chr22:41940476 POLR3H -1.06 -15.01 -0.63 2.89e-39 Vitiligo; LUSC cis rs2760061 0.583 rs1745413 chr1:228212456 A/G cg04850211 chr1:228464232 OBSCN -0.37 -6.21 -0.32 1.58e-9 Diastolic blood pressure; LUSC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg04155289 chr7:94953770 PON1 0.33 5.65 0.3 3.47e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1559088 0.948 rs7259333 chr19:33579128 T/C cg17764715 chr19:33622953 WDR88 0.61 8.36 0.42 1.67e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs3749237 1.000 rs1317140 chr3:49878652 G/A cg21659725 chr3:3221576 CRBN 0.59 8.0 0.4 2.05e-14 Resting heart rate; LUSC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg24549020 chr5:56110836 MAP3K1 -0.48 -5.85 -0.3 1.16e-8 Initial pursuit acceleration; LUSC cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg26384229 chr12:38710491 ALG10B 0.9 15.6 0.65 1.31e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs3782089 0.793 rs34789990 chr11:65252477 G/T cg11802864 chr11:65308245 LTBP3 0.85 5.86 0.31 1.11e-8 Height; LUSC cis rs11153147 0.649 rs10456863 chr6:109299092 A/T cg05315195 chr6:109294784 ARMC2 -0.56 -6.2 -0.32 1.66e-9 Mean corpuscular volume; LUSC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg09034736 chr1:150693464 HORMAD1 0.46 6.73 0.35 7.26e-11 Tonsillectomy; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg16325326 chr1:53192061 ZYG11B 0.86 15.37 0.64 1.05e-40 Monocyte count; LUSC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg00255919 chr5:131827918 IRF1 -0.43 -8.25 -0.41 3.61e-15 Asthma (sex interaction); LUSC cis rs79387448 0.745 rs17027428 chr2:103163175 G/A cg09003973 chr2:102972529 NA 0.89 8.62 0.43 2.69e-16 Gut microbiota (bacterial taxa); LUSC cis rs4363385 0.667 rs454186 chr1:153049149 C/T cg00922841 chr1:152955080 SPRR1A -0.42 -7.24 -0.37 3.05e-12 Inflammatory skin disease; LUSC trans rs9944715 0.734 rs9967220 chr18:43780059 C/T cg01718231 chr17:29326311 RNF135 -0.55 -7.83 -0.39 6.7e-14 Red cell distribution width;Mean corpuscular volume; LUSC cis rs5758659 0.622 rs129856 chr22:42399396 C/G cg04733989 chr22:42467013 NAGA 0.38 6.47 0.33 3.58e-10 Cognitive function; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg15985629 chr12:44199522 TWF1 -0.46 -6.13 -0.32 2.47e-9 Hepatitis; LUSC cis rs6977660 0.507 rs4721822 chr7:19771693 T/C cg07541023 chr7:19748670 TWISTNB 0.78 8.21 0.41 4.98e-15 Thyroid stimulating hormone; LUSC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg02487422 chr3:49467188 NICN1 0.47 7.38 0.37 1.27e-12 Resting heart rate; LUSC cis rs11122272 0.766 rs2739511 chr1:231526490 G/C cg06096015 chr1:231504339 EGLN1 0.56 9.82 0.47 3.68e-20 Hemoglobin concentration; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg00431813 chr7:1051703 C7orf50 -0.45 -7.36 -0.37 1.43e-12 Longevity;Endometriosis; LUSC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs10911232 0.507 rs10911195 chr1:182993438 T/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.78 0.51 1.95e-23 Hypertriglyceridemia; LUSC cis rs7804356 1.000 rs28404962 chr7:26860324 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.2 -0.32 1.66e-9 Type 1 diabetes; LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 13.25 0.59 1.72e-32 Alzheimer's disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21483475 chr3:154042025 DHX36 0.38 6.71 0.34 8.44e-11 Triglycerides; LUSC cis rs540254 0.578 rs12117689 chr1:160782100 C/T cg20255094 chr1:160771763 LY9 0.56 6.75 0.35 6.45e-11 Blood protein levels; LUSC trans rs7824557 0.564 rs7828263 chr8:11231886 A/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.35 -0.42 1.82e-15 Retinal vascular caliber; LUSC trans rs2243480 1.000 rs316326 chr7:65609453 T/C cg10756647 chr7:56101905 PSPH 0.88 8.91 0.44 3.39e-17 Diabetic kidney disease; LUSC cis rs12586317 0.582 rs731906 chr14:35604543 C/T cg05294307 chr14:35346193 BAZ1A -0.57 -6.58 -0.34 1.8e-10 Psoriasis; LUSC cis rs2463822 0.583 rs17709552 chr11:62040519 A/G cg06239285 chr11:62104954 ASRGL1 -0.62 -6.43 -0.33 4.49e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg11871910 chr12:69753446 YEATS4 0.84 14.61 0.62 1.03e-37 Blood protein levels; LUSC cis rs965469 0.901 rs6037586 chr20:3368114 G/A cg25506879 chr20:3388711 C20orf194 -0.52 -5.68 -0.3 2.97e-8 IFN-related cytopenia; LUSC trans rs1422110 1.000 rs1422110 chr5:85466140 C/T cg01787110 chr1:109008453 NBPF6 -0.42 -6.65 -0.34 1.16e-10 Attention function in attention deficit hyperactive disorder; LUSC cis rs6722750 0.716 rs6546056 chr2:64414077 A/G cg22352474 chr2:64371530 PELI1 -0.52 -7.64 -0.39 2.31e-13 Neuroticism; LUSC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg05623727 chr3:50126028 RBM5 -0.33 -6.18 -0.32 1.86e-9 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs951366 0.538 rs56276813 chr1:205730573 G/T cg07157834 chr1:205819609 PM20D1 -0.43 -5.65 -0.3 3.52e-8 Menarche (age at onset); LUSC cis rs8070128 0.583 rs7406982 chr17:17942613 C/T cg04398451 chr17:18023971 MYO15A -0.57 -9.44 -0.46 6.61e-19 Total body bone mineral density; LUSC cis rs6163 0.588 rs67506723 chr10:104509064 G/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.76 -0.35 6.05e-11 Waist circumference;Hip circumference; LUSC cis rs3744061 0.505 rs60239313 chr17:74647586 T/C cg27546012 chr17:74684504 MXRA7 -0.36 -6.28 -0.32 1.07e-9 Retinal arteriolar caliber; LUSC cis rs11098499 0.818 rs55825515 chr4:120486402 A/G cg09307838 chr4:120376055 NA 0.76 10.87 0.51 9.13e-24 Corneal astigmatism; LUSC cis rs2692947 0.628 rs1997257 chr2:96429625 A/G cg23100626 chr2:96804247 ASTL 0.24 5.88 0.31 9.81e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4589502 0.925 rs57729347 chr15:67136438 G/A cg12317470 chr15:67143691 NA 0.63 7.15 0.36 5.53e-12 Lung cancer (smoking interaction); LUSC cis rs7799006 0.722 rs33981648 chr7:2288669 T/C cg12823233 chr7:2316876 SNX8 -0.45 -7.64 -0.39 2.24e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.47e-24 Aortic root size; LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg15242686 chr22:24348715 GSTTP1 0.55 8.94 0.44 2.74e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2180341 0.618 rs12529077 chr6:127634244 G/T cg24812749 chr6:127587940 RNF146 0.65 9.79 0.47 4.51e-20 Breast cancer; LUSC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg02079420 chr8:82753780 SNX16 0.41 7.1 0.36 7.48e-12 Diastolic blood pressure; LUSC cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg12011299 chr4:100065546 ADH4 -0.69 -10.8 -0.51 1.66e-23 Alcohol dependence; LUSC cis rs2806561 1.000 rs2806561 chr1:23504795 C/T cg19743168 chr1:23544995 NA -0.41 -8.73 -0.43 1.27e-16 Height; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.34 -0.42 1.94e-15 Lymphocyte counts; LUSC cis rs614226 0.935 rs3887875 chr12:120895749 A/G cg27489772 chr12:121021490 NA -0.6 -7.79 -0.39 8.71e-14 Type 1 diabetes nephropathy; LUSC trans rs2832191 0.703 rs2853827 chr21:30443596 T/C cg14791747 chr16:20752902 THUMPD1 -0.4 -6.13 -0.32 2.47e-9 Dental caries; LUSC cis rs17270561 0.609 rs1408271 chr6:25859621 T/A cg16482183 chr6:26056742 HIST1H1C 0.56 7.92 0.4 3.6e-14 Iron status biomarkers; LUSC cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg18477163 chr1:228402036 OBSCN -0.56 -10.36 -0.49 5.35e-22 Diastolic blood pressure; LUSC cis rs9467160 0.871 rs9461014 chr6:24449008 T/G cg20631270 chr6:24437470 GPLD1 0.44 5.76 0.3 1.94e-8 Liver enzyme levels; LUSC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.49 -6.6 -0.34 1.62e-10 Tonsillectomy; LUSC cis rs11098499 0.532 rs4833624 chr4:120585497 C/T cg24375607 chr4:120327624 NA 0.75 11.06 0.52 2e-24 Corneal astigmatism; LUSC cis rs11758351 0.660 rs56398712 chr6:26213868 A/G cg01420254 chr6:26195488 NA 0.63 7.08 0.36 8.38e-12 Gout;Renal underexcretion gout; LUSC cis rs12136530 0.744 rs16862798 chr1:19777837 A/G cg01832549 chr1:19774989 CAPZB -0.33 -6.1 -0.32 2.96e-9 Lead levels in blood; LUSC cis rs4363385 0.818 rs382292 chr1:153006641 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg00945038 chr17:61921165 SMARCD2 0.53 9.18 0.45 4.46e-18 Prudent dietary pattern; LUSC cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg26762873 chr11:5879799 OR52E8 0.31 6.03 0.31 4.38e-9 DNA methylation (variation); LUSC cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg24642439 chr20:33292090 TP53INP2 -0.73 -12.15 -0.55 2.3e-28 Coronary artery disease; LUSC cis rs926938 0.527 rs360685 chr1:115499795 G/C cg01522456 chr1:115632236 TSPAN2 -0.41 -6.41 -0.33 5.01e-10 Autism; LUSC cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs9399135 0.967 rs59329760 chr6:135342437 G/A cg24558204 chr6:135376177 HBS1L 0.6 9.42 0.46 7.41e-19 Red blood cell count; LUSC cis rs4423214 0.592 rs11233977 chr11:71221605 C/T cg05163923 chr11:71159392 DHCR7 -0.69 -7.06 -0.36 9.73e-12 Vitamin D levels; LUSC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg18350739 chr11:68623251 NA -0.38 -6.43 -0.33 4.36e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.53e-8 Menopause (age at onset); LUSC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg26677194 chr12:130822605 PIWIL1 0.59 8.79 0.43 7.9e-17 Menopause (age at onset); LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg13047869 chr3:10149882 C3orf24 0.64 8.43 0.42 1.06e-15 Alzheimer's disease; LUSC cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg24642439 chr20:33292090 TP53INP2 -0.68 -10.85 -0.51 1.09e-23 Coronary artery disease; LUSC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.81 -0.35 4.68e-11 Intelligence (multi-trait analysis); LUSC cis rs2295359 1.000 rs4655684 chr1:67611772 A/G cg03340356 chr1:67600835 NA -0.39 -6.2 -0.32 1.66e-9 Psoriasis; LUSC cis rs6696846 0.765 rs2836 chr1:205111761 G/T cg00857998 chr1:205179979 DSTYK -0.64 -10.13 -0.48 3.22e-21 Red blood cell count; LUSC cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.08e-8 Breast cancer; LUSC trans rs17607347 0.542 rs1429071 chr16:72452277 A/G cg22321522 chr19:15490619 AKAP8 -0.57 -5.96 -0.31 6.43e-9 Intelligence (multi-trait analysis); LUSC cis rs6693567 0.565 rs6685252 chr1:150259945 T/A cg15654264 chr1:150340011 RPRD2 -0.44 -7.08 -0.36 8.57e-12 Migraine; LUSC cis rs4946717 0.740 rs9480634 chr6:106468486 C/T cg02270332 chr6:106475062 NA 0.45 9.33 0.45 1.46e-18 Inflammatory bowel disease; LUSC cis rs977987 0.806 rs4887818 chr16:75361995 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.91 -0.35 2.43e-11 Dupuytren's disease; LUSC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg02423579 chr7:2872169 GNA12 -0.45 -6.69 -0.34 9.32e-11 Height; LUSC cis rs9326248 0.581 rs10892053 chr11:116857003 C/T cg20608306 chr11:116969690 SIK3 0.37 6.96 0.36 1.8e-11 Blood protein levels; LUSC cis rs10740039 1.000 rs10740039 chr10:62414682 C/G cg18175470 chr10:62150864 ANK3 -0.39 -6.17 -0.32 1.93e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10435719 0.899 rs9693925 chr8:11789963 A/G cg21775007 chr8:11205619 TDH 0.46 6.57 0.34 1.93e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9394438 0.628 rs4714080 chr6:37544618 A/G cg00985040 chr6:37553208 NA 0.39 8.75 0.43 1.11e-16 IgG glycosylation; LUSC cis rs2953145 0.545 rs2975751 chr2:241521135 G/A cg07929629 chr2:241523174 NA 0.62 10.96 0.51 4.49e-24 Bipolar disorder; LUSC cis rs3760982 1.000 rs60184524 chr19:44294215 A/G cg11993925 chr19:44307056 LYPD5 0.28 6.21 0.32 1.59e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs9457247 1.000 rs10946199 chr6:167404492 G/A cg20406979 chr6:167373233 NA 0.26 6.09 0.32 3.07e-9 Crohn's disease; LUSC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.2 -0.32 1.62e-9 Life satisfaction; LUSC cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.49 8.06 0.4 1.35e-14 IgG glycosylation; LUSC cis rs354225 0.544 rs12713266 chr2:54805443 G/T cg01766943 chr2:54829624 SPTBN1 0.48 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg06092702 chr1:163392909 NA 0.42 6.96 0.36 1.86e-11 Motion sickness; LUSC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg05368731 chr17:41323189 NBR1 0.94 16.07 0.66 1.97e-43 Menopause (age at onset); LUSC cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg05283184 chr6:79620031 NA 0.58 12.24 0.56 1.01e-28 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.737 rs11886117 chr2:238361650 A/T cg16989719 chr2:238392110 NA -0.37 -6.45 -0.33 3.87e-10 Prostate cancer; LUSC cis rs868036 0.681 rs13329567 chr15:68104367 C/T cg08079166 chr15:68083412 MAP2K5 0.41 7.29 0.37 2.33e-12 Restless legs syndrome; LUSC cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg11161846 chr1:160990452 F11R -0.35 -6.38 -0.33 5.79e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs34779708 0.931 rs10437420 chr10:35335044 A/C cg03585969 chr10:35415529 CREM -0.63 -9.25 -0.45 2.65e-18 Inflammatory bowel disease;Crohn's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02119927 chr10:71078141 HK1 -0.41 -6.14 -0.32 2.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg12165864 chr7:66369176 NA -0.51 -6.77 -0.35 5.64e-11 Corneal structure; LUSC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg20503657 chr10:835505 NA 0.98 14.25 0.61 2.6e-36 Eosinophil percentage of granulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04552940 chr2:27712630 IFT172 -0.42 -6.29 -0.33 1.02e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg27284194 chr4:1044797 NA 0.35 5.99 0.31 5.54e-9 Obesity-related traits; LUSC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg00484396 chr16:3507460 NAT15 -0.91 -10.66 -0.5 5.13e-23 Tuberculosis; LUSC cis rs2376015 1 rs2376015 chr1:66123774 A/G cg04111102 chr1:66153794 NA 0.33 7.24 0.37 3.19e-12 Fibrinogen levels; LUSC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg12463550 chr7:65579703 CRCP 0.45 6.62 0.34 1.44e-10 Aortic root size; LUSC cis rs9865818 0.626 rs2889896 chr3:188102716 C/T cg23651889 chr3:188115336 LPP -0.38 -5.72 -0.3 2.33e-8 Allergic sensitization; LUSC cis rs9875589 0.509 rs9836573 chr3:14065239 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.12 0.36 6.54e-12 Ovarian reserve; LUSC cis rs17345786 0.520 rs13062677 chr3:101305078 G/A cg12386194 chr3:101231763 SENP7 0.4 5.74 0.3 2.16e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs4841097 0.806 rs6992247 chr8:8948469 G/T cg15556689 chr8:8085844 FLJ10661 0.42 6.12 0.32 2.69e-9 Platelet distribution width; LUSC cis rs10489525 0.599 rs7526323 chr1:115604241 G/A cg17147537 chr1:115611705 TSPAN2 0.3 6.07 0.32 3.53e-9 Autism; LUSC trans rs10221833 0.636 rs355876 chr2:165632858 T/G cg26993132 chr16:89239499 CDH15 0.31 5.99 0.31 5.4e-9 Response to statin therapy; LUSC cis rs4594175 0.707 rs4901102 chr14:51746605 C/T cg23942311 chr14:51606299 NA -0.29 -6.01 -0.31 4.78e-9 Cancer; LUSC trans rs7647973 0.593 rs9870755 chr3:49809841 A/G cg21659725 chr3:3221576 CRBN -0.62 -7.63 -0.39 2.47e-13 Menarche (age at onset); LUSC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9479482 0.967 rs1853664 chr6:150355266 A/G cg25797454 chr6:150327115 RAET1K 0.33 7.49 0.38 6.34e-13 Alopecia areata; LUSC cis rs34330 0.562 rs11055025 chr12:12866619 A/T cg04607235 chr12:12878440 APOLD1 -0.51 -5.81 -0.3 1.43e-8 Systemic lupus erythematosus; LUSC cis rs17095355 1.000 rs17126902 chr10:111710381 A/G cg00817464 chr10:111662876 XPNPEP1 0.67 8.4 0.42 1.26e-15 Biliary atresia; LUSC cis rs877282 0.945 rs10904556 chr10:789429 A/G cg17470449 chr10:769945 NA 0.49 6.71 0.34 8.1e-11 Uric acid levels; LUSC cis rs4704187 0.687 rs922390 chr5:74401269 A/G cg03227963 chr5:74354835 NA 0.32 6.82 0.35 4.4e-11 Response to amphetamines; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg03433033 chr1:76189801 ACADM 0.79 11.34 0.53 1.97e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg04727924 chr7:799746 HEATR2 0.53 6.24 0.32 1.35e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg07507251 chr3:52567010 NT5DC2 0.34 6.54 0.34 2.27e-10 Bipolar disorder; LUSC cis rs2273669 0.667 rs12204576 chr6:109318843 A/G cg05315195 chr6:109294784 ARMC2 -0.53 -5.94 -0.31 7.15e-9 Prostate cancer; LUSC cis rs4845459 0.967 rs10888503 chr1:152593549 C/T cg08895932 chr1:152778580 LCE1C -0.38 -6.49 -0.33 3.07e-10 Psoriasis; LUSC cis rs4290604 0.748 rs12692198 chr2:238057391 C/A cg23555395 chr2:238036564 NA -0.52 -6.94 -0.35 2.07e-11 Asthma; LUSC cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.23 0.45 3.29e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1595825 0.891 rs6707521 chr2:198713231 A/G cg19156104 chr2:198669113 PLCL1 0.46 5.64 0.3 3.54e-8 Ulcerative colitis; LUSC cis rs11711311 0.712 rs11718013 chr3:113341661 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -5.77 -0.3 1.84e-8 IgG glycosylation; LUSC cis rs74181299 0.890 rs2723062 chr2:65280220 G/A cg05010058 chr2:65284262 CEP68 0.31 6.14 0.32 2.3e-9 Pulse pressure; LUSC cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg15485101 chr11:133734466 NA -0.34 -6.26 -0.32 1.18e-9 Childhood ear infection; LUSC cis rs7954584 0.523 rs11043280 chr12:122426643 T/C cg01765077 chr12:122356316 WDR66 0.51 7.27 0.37 2.52e-12 Mean corpuscular volume; LUSC cis rs17253792 0.822 rs77197405 chr14:56159662 T/A cg01858014 chr14:56050164 KTN1 -0.84 -6.83 -0.35 4.13e-11 Putamen volume; LUSC cis rs9362426 1.000 rs9362426 chr6:88089874 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.36 5.71 0.3 2.51e-8 Depressive episodes in bipolar disorder; LUSC cis rs4566357 1.000 rs6705783 chr2:227923268 C/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.8 -0.3 1.57e-8 Coronary artery disease; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg18765753 chr7:1198926 ZFAND2A -0.58 -11.06 -0.52 1.97e-24 Longevity;Endometriosis; LUSC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.57 -0.34 1.94e-10 Schizophrenia; LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg06238570 chr21:40685208 BRWD1 0.46 7.13 0.36 6.22e-12 Cognitive function; LUSC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg17173187 chr15:85201210 NMB -0.31 -6.38 -0.33 6.01e-10 P wave terminal force; LUSC trans rs7618501 0.633 rs9814664 chr3:50078541 C/T cg21659725 chr3:3221576 CRBN -0.64 -10.63 -0.5 6.13e-23 Intelligence (multi-trait analysis); LUSC cis rs6998277 0.830 rs7017839 chr8:103610769 G/C cg10187029 chr8:103597600 NA 0.79 12.21 0.56 1.39e-28 Migraine; LUSC cis rs7586879 0.828 rs2384056 chr2:25092649 G/A cg01884057 chr2:25150051 NA 0.4 8.18 0.41 5.98e-15 Body mass index; LUSC cis rs3008870 1.000 rs3008848 chr1:67379284 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.26 0.64 2.81e-40 Lymphocyte percentage of white cells; LUSC cis rs7923609 0.756 rs7090758 chr10:65335315 T/C cg01631684 chr10:65280961 REEP3 0.38 5.72 0.3 2.42e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7923609 0.869 rs10733792 chr10:65232539 A/G cg01631684 chr10:65280961 REEP3 -0.42 -6.44 -0.33 4.1e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs1997103 0.871 rs1997100 chr7:55399656 C/G cg20935933 chr6:143382018 AIG1 0.51 7.4 0.38 1.08e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10911232 0.507 rs4652772 chr1:183023696 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.69 -10.67 -0.5 4.7e-23 Hypertriglyceridemia; LUSC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg26513180 chr16:89883248 FANCA 0.63 5.86 0.31 1.11e-8 Skin colour saturation; LUSC cis rs713477 0.935 rs4901564 chr14:55912409 G/T cg13175173 chr14:55914753 NA -0.32 -6.78 -0.35 5.42e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg04317338 chr11:64019027 PLCB3 0.66 7.41 0.38 1.06e-12 Mean platelet volume; LUSC cis rs4343996 0.967 rs7803993 chr7:3353057 G/A cg21248987 chr7:3385318 SDK1 -0.39 -6.61 -0.34 1.57e-10 Motion sickness; LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg01256987 chr12:42539512 GXYLT1 -0.44 -8.29 -0.41 2.74e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.57 7.97 0.4 2.59e-14 Chronic sinus infection; LUSC cis rs9287719 0.967 rs7600728 chr2:10739999 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg23583168 chr7:148888333 NA -0.91 -17.45 -0.69 6.14e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.59 -0.54 2.5e-26 Schizophrenia; LUSC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.07 -0.32 3.41e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs198712 0.505 rs198314 chr7:24191005 C/T cg06529468 chr19:10676722 KRI1 0.38 6.1 0.32 2.89e-9 Aggressive periodontitis (sex interaction); LUSC cis rs3087591 0.922 rs9892839 chr17:29618990 A/G cg24425628 chr17:29625626 OMG;NF1 -0.57 -8.21 -0.41 5.05e-15 Hip circumference; LUSC cis rs7267979 0.932 rs4280527 chr20:25544014 A/G cg08601574 chr20:25228251 PYGB 0.41 6.2 0.32 1.65e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.82 0.6 1.14e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.17 0.55 1.95e-28 Colorectal cancer; LUSC cis rs9914988 0.945 rs9279 chr17:27187636 G/T cg09479241 chr17:27052676 TLCD1 -0.42 -5.68 -0.3 2.92e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9300255 0.508 rs1716176 chr12:123655467 T/G cg13010344 chr12:123464640 ARL6IP4 -0.44 -6.04 -0.31 4.09e-9 Neutrophil percentage of white cells; LUSC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.42 -0.46 7.85e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg04450456 chr4:17643702 FAM184B -0.4 -6.55 -0.34 2.24e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9926296 0.656 rs4522419 chr16:89853307 T/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.39 5.94 0.31 7.16e-9 Vitiligo; LUSC cis rs6500602 0.826 rs11076831 chr16:4460133 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.55 -6.81 -0.35 4.42e-11 Schizophrenia; LUSC cis rs1018697 1.000 rs10748830 chr10:104548382 A/C cg04362960 chr10:104952993 NT5C2 0.47 6.45 0.33 4e-10 Colorectal adenoma (advanced); LUSC cis rs503341 0.756 rs10897450 chr11:63593219 G/C cg04362095 chr11:63592001 C11orf84 -0.57 -8.72 -0.43 1.32e-16 Pulse pressure; LUSC cis rs2294693 0.891 rs1072119 chr6:40993072 G/A cg14769373 chr6:40998127 UNC5CL -0.51 -7.12 -0.36 6.84e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs12908161 1.000 rs17601029 chr15:85347709 A/G cg17173187 chr15:85201210 NMB 0.47 8.86 0.44 4.87e-17 Schizophrenia; LUSC cis rs506338 0.517 rs530775 chr11:64426933 A/G cg19395706 chr11:64412079 NRXN2 0.29 5.92 0.31 7.91e-9 Body mass index;Urate levels; LUSC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.48 0.53 5.9e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs62103177 0.789 rs7242289 chr18:77603291 C/T cg05926928 chr17:57297772 GDPD1 1.45 17.98 0.7 5.08e-51 Opioid sensitivity; LUSC cis rs10097731 0.901 rs4398860 chr8:82041753 C/T cg25230327 chr8:82042993 NA -0.47 -6.66 -0.34 1.1e-10 Serum total protein level; LUSC cis rs7937682 0.632 rs10891297 chr11:111770150 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.47 0.56 1.45e-29 Primary sclerosing cholangitis; LUSC cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg27446573 chr6:127587934 RNF146 0.91 15.15 0.64 7.89e-40 Breast cancer; LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg08219700 chr8:58056026 NA 0.56 7.69 0.39 1.62e-13 Developmental language disorder (linguistic errors); LUSC cis rs1865721 0.755 rs3813081 chr18:73185096 A/G cg26385618 chr18:73139727 C18orf62 -0.42 -7.13 -0.36 6.11e-12 Intelligence; LUSC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg21951975 chr1:209979733 IRF6 0.61 7.89 0.4 4.43e-14 Cleft lip with or without cleft palate; LUSC cis rs9527 0.590 rs7073323 chr10:104797423 A/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.33 -0.33 7.98e-10 Arsenic metabolism; LUSC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.11 0.48 3.78e-21 Bipolar disorder; LUSC cis rs6500602 0.727 rs4238849 chr16:4538114 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 6.48 0.33 3.36e-10 Schizophrenia; LUSC cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg15557168 chr22:42548783 NA 0.35 5.84 0.3 1.25e-8 Cognitive function; LUSC cis rs10266483 0.774 rs4718067 chr7:63816396 A/G cg24201672 chr7:64023550 ZNF680 -0.45 -5.86 -0.31 1.09e-8 Response to statin therapy; LUSC cis rs6120849 0.707 rs6088690 chr20:33633326 A/G cg24642439 chr20:33292090 TP53INP2 0.6 6.58 0.34 1.8e-10 Protein C levels; LUSC cis rs17014483 0.749 rs2924936 chr4:89641514 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.68 6.14 0.32 2.29e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4629710 0.545 rs3777477 chr6:131534374 T/C cg12700074 chr6:131571435 AKAP7 -0.37 -6.13 -0.32 2.48e-9 Multiple myeloma (IgH translocation); LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs951366 0.576 rs12046305 chr1:205714478 G/A cg07167872 chr1:205819463 PM20D1 -0.44 -5.94 -0.31 7.24e-9 Menarche (age at onset); LUSC cis rs950027 0.620 rs2453533 chr15:45641225 C/A cg14582100 chr15:45693742 SPATA5L1 0.45 8.47 0.42 7.77e-16 Response to fenofibrate (adiponectin levels); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05653691 chr1:16175060 FLJ37453;SPEN -0.41 -6.2 -0.32 1.71e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs55910451 0.732 rs2797496 chr10:5801232 A/C cg11519256 chr10:5708881 ASB13 -0.5 -6.27 -0.32 1.1e-9 Breast cancer; LUSC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg05776053 chr2:74358815 NA 0.44 7.04 0.36 1.07e-11 Gestational age at birth (maternal effect); LUSC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.76 14.05 0.61 1.54e-35 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.516 rs12814528 chr12:38296111 G/A cg26384229 chr12:38710491 ALG10B -0.57 -8.49 -0.42 6.96e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs61931739 0.500 rs10844864 chr12:34532468 A/G cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.52e-11 Morning vs. evening chronotype; LUSC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.78 7.71 0.39 1.47e-13 Initial pursuit acceleration; LUSC cis rs1395 0.922 rs1561535 chr2:27471025 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.36 5.83 0.3 1.32e-8 Blood metabolite levels; LUSC cis rs7089973 0.628 rs11196953 chr10:116607707 A/G cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs8038465 1.000 rs8032531 chr15:73977271 A/G cg15420318 chr15:73925796 NPTN 0.42 6.61 0.34 1.54e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7923452 0.507 rs103441 chr10:30778184 C/T cg18806716 chr10:30721971 MAP3K8 -0.57 -8.67 -0.43 1.9e-16 Itch intensity from mosquito bite; LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg07677032 chr17:61819896 STRADA -0.56 -9.14 -0.45 6.16e-18 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.76 0.47 5.88e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7208859 0.623 rs426434 chr17:28925353 C/T cg13385521 chr17:29058706 SUZ12P 0.58 5.68 0.3 2.87e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7119 0.651 rs34829483 chr15:77835986 C/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.41 -0.33 4.89e-10 Type 2 diabetes; LUSC cis rs9395066 0.545 rs35357222 chr6:44940552 C/G cg25276700 chr6:44698697 NA 0.29 5.86 0.31 1.08e-8 Height; LUSC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC cis rs7929679 0.521 rs7122506 chr11:34786853 A/G cg06937548 chr11:34938143 PDHX;APIP 0.4 5.87 0.31 1.03e-8 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg24829409 chr8:58192753 C8orf71 -0.62 -6.81 -0.35 4.59e-11 Developmental language disorder (linguistic errors); LUSC cis rs4474465 1.000 rs10899522 chr11:78190763 C/G cg27205649 chr11:78285834 NARS2 0.49 5.97 0.31 5.95e-9 Alzheimer's disease (survival time); LUSC cis rs7618501 0.933 rs3811695 chr3:49761613 C/T cg24110177 chr3:50126178 RBM5 0.41 6.48 0.33 3.2e-10 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.0 0.31 5.27e-9 Lung cancer; LUSC trans rs28735056 0.660 rs12454454 chr18:77674634 C/T cg05926928 chr17:57297772 GDPD1 -0.48 -6.78 -0.35 5.6e-11 Schizophrenia; LUSC cis rs9814567 1.000 rs7433991 chr3:134312292 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.07e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4654899 0.865 rs6664532 chr1:21515800 G/A cg01072550 chr1:21505969 NA -0.52 -7.89 -0.4 4.41e-14 Superior frontal gyrus grey matter volume; LUSC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg16545954 chr1:2118288 C1orf86 0.38 7.33 0.37 1.69e-12 Height; LUSC cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.71 0.7 5.75e-50 Chronic sinus infection; LUSC cis rs56104184 0.830 rs17272645 chr19:49342366 C/G cg15549821 chr19:49342101 PLEKHA4 0.84 11.27 0.52 3.53e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs6714710 0.603 rs13008968 chr2:98435982 C/T cg26665480 chr2:98280029 ACTR1B 0.59 8.65 0.43 2.26e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg23758822 chr17:41437982 NA 1.03 19.58 0.73 2.08e-57 Menopause (age at onset); LUSC cis rs7119 0.667 rs907393 chr15:77903447 T/C cg27398640 chr15:77910606 LINGO1 0.38 8.86 0.44 4.7e-17 Type 2 diabetes; LUSC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg11645453 chr3:52864694 ITIH4 0.28 6.55 0.34 2.2e-10 Electroencephalogram traits; LUSC cis rs9296092 0.560 rs9469506 chr6:33527897 A/G cg13560919 chr6:33536144 NA -0.85 -16.44 -0.67 6.54e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs7647973 0.626 rs9835157 chr3:49797769 G/A cg21659725 chr3:3221576 CRBN 0.68 8.24 0.41 3.83e-15 Menarche (age at onset); LUSC cis rs4851254 0.550 rs13402299 chr2:100659409 C/T cg07810366 chr2:100720526 AFF3 -0.46 -5.95 -0.31 6.87e-9 Intelligence (multi-trait analysis); LUSC cis rs9341808 0.718 rs3828754 chr6:80900640 C/G cg08355045 chr6:80787529 NA 0.59 10.22 0.49 1.64e-21 Sitting height ratio; LUSC cis rs61931739 0.517 rs11513277 chr12:34074799 G/T cg06521331 chr12:34319734 NA -0.47 -7.63 -0.39 2.47e-13 Morning vs. evening chronotype; LUSC cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.55 -0.46 2.96e-19 Bone mineral density; LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.4 -5.9 -0.31 9.05e-9 Renal function-related traits (BUN); LUSC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg04166393 chr7:2884313 GNA12 -0.43 -5.97 -0.31 6.2e-9 Height; LUSC cis rs7772486 0.875 rs6570738 chr6:146412695 G/A cg05347473 chr6:146136440 FBXO30 0.49 8.23 0.41 4.25e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg08048268 chr3:133502702 NA -0.46 -8.98 -0.44 2.05e-17 Iron status biomarkers; LUSC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg04267008 chr7:1944627 MAD1L1 -0.45 -6.46 -0.33 3.63e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg02187348 chr16:89574699 SPG7 0.5 7.77 0.39 9.64e-14 Multiple myeloma (IgH translocation); LUSC cis rs1971762 0.583 rs12810378 chr12:54091838 G/T cg23533419 chr12:54090519 NA -0.37 -5.96 -0.31 6.52e-9 Height; LUSC cis rs3806843 0.900 rs2563287 chr5:140124786 C/T cg19875535 chr5:140030758 IK 0.48 7.89 0.4 4.32e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg18230493 chr5:56204884 C5orf35 -0.92 -14.05 -0.61 1.47e-35 Initial pursuit acceleration; LUSC cis rs9399135 0.967 rs11755229 chr6:135369913 A/G cg24558204 chr6:135376177 HBS1L 0.57 8.77 0.43 9.11e-17 Red blood cell count; LUSC cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -8.78 -0.43 8.95e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.9 -0.35 2.64e-11 Aortic root size; LUSC cis rs68170813 0.559 rs12536491 chr7:106978024 T/G cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.66 -0.3 3.35e-8 Coronary artery disease; LUSC cis rs6933660 0.536 rs3800274 chr6:151759192 T/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.5 -6.3 -0.33 9.26e-10 Menarche (age at onset); LUSC cis rs2290416 0.892 rs3793372 chr8:144664233 A/C cg14809332 chr8:144654887 C8orf73 0.5 6.09 0.32 3.13e-9 Attention deficit hyperactivity disorder; LUSC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.42 0.5 3.26e-22 Homoarginine levels; LUSC cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs9649213 0.614 rs4729432 chr7:97947055 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.72 -10.23 -0.49 1.5e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs478304 0.903 rs495961 chr11:65540886 C/T cg05805236 chr11:65401703 PCNXL3 0.41 6.85 0.35 3.47e-11 Acne (severe); LUSC cis rs5769707 0.609 rs135861 chr22:49998118 A/G cg05373962 chr22:49881684 NA -0.41 -8.64 -0.43 2.33e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg03388025 chr16:89894329 SPIRE2 0.31 6.47 0.33 3.52e-10 Vitiligo; LUSC cis rs983392 0.709 rs2081547 chr11:59989430 C/T cg02771260 chr11:59836817 MS4A3 -0.36 -5.92 -0.31 8.18e-9 Alzheimer's disease (late onset); LUSC cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg11266682 chr4:10021025 SLC2A9 -0.46 -8.66 -0.43 2.09e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg11663144 chr21:46675770 NA -0.41 -7.18 -0.37 4.61e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs208515 0.525 rs12193560 chr6:66690457 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.27 0.62 2.12e-36 Exhaled nitric oxide levels; LUSC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg16624210 chr5:671434 TPPP 0.49 6.19 0.32 1.76e-9 Obesity-related traits; LUSC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.39e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg17173187 chr15:85201210 NMB 0.36 5.87 0.31 1.06e-8 Schizophrenia; LUSC cis rs4704187 0.687 rs6862754 chr5:74427193 T/C cg03227963 chr5:74354835 NA 0.32 6.89 0.35 2.81e-11 Response to amphetamines; LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg25036284 chr2:26402008 FAM59B -0.77 -11.38 -0.53 1.46e-25 Gut microbiome composition (summer); LUSC cis rs2997447 0.655 rs2275949 chr1:26385150 C/G cg19633962 chr1:26362018 EXTL1 -0.61 -7.49 -0.38 6.15e-13 QRS complex (12-leadsum); LUSC cis rs478304 0.514 rs75601653 chr11:65483370 C/G cg05805236 chr11:65401703 PCNXL3 -0.64 -10.4 -0.49 3.8e-22 Acne (severe); LUSC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg08219700 chr8:58056026 NA 0.68 7.76 0.39 1.05e-13 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.592 rs6519270 chr22:42078666 A/G cg03806693 chr22:41940476 POLR3H 0.9 13.1 0.58 6.27e-32 Vitiligo; LUSC cis rs9322817 0.691 rs9404586 chr6:105332814 A/G cg02098413 chr6:105308735 HACE1 0.28 5.94 0.31 7.34e-9 Thyroid stimulating hormone; LUSC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg24920358 chr1:40204285 PPIE 0.6 10.7 0.51 3.61e-23 Blood protein levels; LUSC cis rs1538970 0.924 rs2088100 chr1:45877575 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.71 0.3 2.51e-8 Platelet count; LUSC cis rs9517320 0.515 rs9556972 chr13:99209815 C/T cg20487152 chr13:99095054 FARP1 -0.4 -6.9 -0.35 2.67e-11 Longevity; LUSC cis rs11098499 0.820 rs11737395 chr4:120520704 C/G cg09307838 chr4:120376055 NA 0.71 10.34 0.49 6.26e-22 Corneal astigmatism; LUSC cis rs897984 0.770 rs3813020 chr16:30934075 G/A cg02466173 chr16:30829666 NA 0.56 11.19 0.52 6.77e-25 Dementia with Lewy bodies; LUSC cis rs12541635 1.000 rs1864320 chr8:107088979 C/T cg10147462 chr8:107024639 NA 0.48 8.98 0.44 1.96e-17 Age of smoking initiation; LUSC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg14416269 chr4:6271139 WFS1 0.52 10.93 0.51 5.39e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs7786808 0.741 rs62479982 chr7:158227546 A/G cg02030672 chr11:45687055 CHST1 0.44 6.65 0.34 1.19e-10 Obesity-related traits; LUSC cis rs4253772 0.938 rs75977757 chr22:46641525 G/T cg18190219 chr22:46762943 CELSR1 -0.52 -6.02 -0.31 4.71e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs1728785 1.000 rs11647432 chr16:68565426 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg11764359 chr7:65958608 NA 0.54 7.11 0.36 7.23e-12 Aortic root size; LUSC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs79349575 0.783 rs2088139 chr17:47000110 C/T cg22482690 chr17:47019901 SNF8 0.4 7.59 0.38 3.17e-13 Type 2 diabetes; LUSC cis rs501916 0.602 rs472081 chr15:48058652 G/T cg16110827 chr15:48056943 SEMA6D -0.38 -5.93 -0.31 7.5e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg23625390 chr15:77176239 SCAPER -0.42 -6.43 -0.33 4.54e-10 Blood metabolite levels; LUSC cis rs27434 0.607 rs26654 chr5:96140367 C/T cg16492584 chr5:96139282 ERAP1 -0.58 -7.9 -0.4 4.08e-14 Ankylosing spondylitis; LUSC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs13064411 0.696 rs9860549 chr3:113148368 G/A cg18753928 chr3:113234510 CCDC52 -0.44 -6.76 -0.35 6.31e-11 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg07148914 chr20:33460835 GGT7 -0.55 -8.35 -0.42 1.88e-15 Height; LUSC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg22857025 chr5:266934 NA -1.18 -16.59 -0.67 1.59e-45 Breast cancer; LUSC cis rs4604732 0.642 rs7549312 chr1:247640078 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.36 5.82 0.3 1.38e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg17279839 chr7:150038598 RARRES2 0.51 7.83 0.39 6.46e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg01448562 chr3:133502909 NA -0.66 -10.66 -0.5 4.99e-23 Iron status biomarkers; LUSC cis rs28374715 0.662 rs521890 chr15:41473143 C/T cg18705301 chr15:41695430 NDUFAF1 -0.81 -14.85 -0.63 1.19e-38 Ulcerative colitis; LUSC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg13206674 chr6:150067644 NUP43 0.62 10.08 0.48 4.87e-21 Lung cancer; LUSC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg21963583 chr11:68658836 MRPL21 0.56 8.57 0.42 3.8e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg19077165 chr18:44547161 KATNAL2 -0.38 -5.85 -0.3 1.19e-8 Personality dimensions; LUSC cis rs9300255 0.679 rs4759420 chr12:123794871 G/C cg00376283 chr12:123451042 ABCB9 0.66 7.74 0.39 1.2e-13 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg13736514 chr6:26305472 NA -0.45 -8.75 -0.43 1.08e-16 Educational attainment; LUSC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 12.64 0.57 3.43e-30 Total body bone mineral density; LUSC cis rs9503598 0.778 rs10155771 chr6:3465930 G/A cg00476032 chr6:3446245 SLC22A23 0.38 7.52 0.38 5.25e-13 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4243830 0.850 rs4908911 chr1:6599523 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -9.64 -0.47 1.4e-19 Body mass index; LUSC cis rs12464483 0.524 rs4952172 chr2:30888286 A/G cg07150166 chr2:30669952 LCLAT1 -0.52 -6.14 -0.32 2.33e-9 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg19230755 chr7:65878503 NA 0.41 5.76 0.3 1.95e-8 Aortic root size; LUSC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg08219700 chr8:58056026 NA 0.49 6.0 0.31 5.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs7937682 1.000 rs11213980 chr11:111562692 A/T cg09085632 chr11:111637200 PPP2R1B 1.04 15.89 0.66 9.39e-43 Primary sclerosing cholangitis; LUSC trans rs877282 0.891 rs12767062 chr10:797961 C/T cg13042288 chr15:90349979 ANPEP -0.5 -7.06 -0.36 9.79e-12 Uric acid levels; LUSC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21659725 chr3:3221576 CRBN -0.9 -18.76 -0.72 3.77e-54 Intelligence (multi-trait analysis); LUSC cis rs734999 0.588 rs2260976 chr1:2527678 A/G cg18932078 chr1:2524107 MMEL1 -0.32 -7.12 -0.36 6.57e-12 Ulcerative colitis; LUSC cis rs2456568 0.548 rs7105031 chr11:93661207 C/T cg26875233 chr11:93583750 C11orf90 -0.31 -6.06 -0.31 3.76e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19006050 chr10:131904236 NA -0.44 -6.43 -0.33 4.32e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4604732 0.536 rs78019731 chr1:247626430 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg24060327 chr5:131705240 SLC22A5 -0.67 -11.67 -0.54 1.22e-26 Breast cancer; LUSC trans rs2797160 0.967 rs1777182 chr6:126013614 T/A cg05039488 chr6:79577232 IRAK1BP1 0.43 6.34 0.33 7.63e-10 Endometrial cancer; LUSC cis rs727505 1.000 rs10281582 chr7:124423688 A/G cg23710748 chr7:124431027 NA -0.4 -7.13 -0.36 6.15e-12 Lewy body disease; LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg25072359 chr17:41440525 NA 0.66 9.5 0.46 4.09e-19 Menopause (age at onset); LUSC cis rs834603 0.547 rs1704966 chr7:47469948 G/A cg09696706 chr7:47479511 TNS3 0.33 5.9 0.31 8.81e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs2439831 0.850 rs7163245 chr15:43671294 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.06 12.91 0.58 3.43e-31 Lung cancer in ever smokers; LUSC cis rs13256369 0.802 rs35382339 chr8:8559255 G/A cg00074818 chr8:8560427 CLDN23 0.59 9.54 0.46 3.07e-19 Obesity-related traits; LUSC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.6 12.42 0.56 2.18e-29 Monocyte percentage of white cells; LUSC cis rs6840360 0.533 rs13145446 chr4:152729035 G/A cg22705602 chr4:152727874 NA 0.34 7.14 0.36 5.92e-12 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.702 rs2086824 chr16:89471246 G/T cg02187348 chr16:89574699 SPG7 -0.37 -5.67 -0.3 3.08e-8 Multiple myeloma (IgH translocation); LUSC trans rs1325195 0.920 rs380474 chr1:179217448 C/T cg11624085 chr17:8464688 MYH10 0.44 7.1 0.36 7.36e-12 IgE grass sensitization; LUSC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg08645402 chr16:4508243 NA 0.48 7.5 0.38 5.74e-13 Schizophrenia; LUSC cis rs6495122 0.501 rs12904227 chr15:75387048 A/C cg09165964 chr15:75287851 SCAMP5 -0.46 -6.76 -0.35 6.06e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg15242686 chr22:24348715 GSTTP1 0.53 8.39 0.42 1.35e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13242816 1.000 rs17138708 chr7:116109062 T/G cg16553024 chr7:116138462 CAV2 -0.54 -5.92 -0.31 7.84e-9 P wave duration; LUSC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.5 0.42 6.61e-16 Menarche (age at onset); LUSC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg01448562 chr3:133502909 NA 0.52 7.85 0.39 5.57e-14 Iron status biomarkers; LUSC cis rs7586879 0.609 rs7608976 chr2:25075281 G/A cg04586622 chr2:25135609 ADCY3 0.39 8.04 0.4 1.58e-14 Body mass index; LUSC cis rs9796 0.717 rs476633 chr15:41392134 C/G cg18705301 chr15:41695430 NDUFAF1 -0.47 -8.27 -0.41 3.13e-15 Menopause (age at onset); LUSC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg14004847 chr7:1930337 MAD1L1 -0.52 -7.86 -0.4 5.2e-14 Bipolar disorder and schizophrenia; LUSC cis rs2652834 1.000 rs11637852 chr15:63397151 G/A cg05507819 chr15:63340323 TPM1 0.68 8.15 0.41 7.29e-15 HDL cholesterol; LUSC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg12412775 chr1:25698385 RHCE -0.29 -5.76 -0.3 1.86e-8 Erythrocyte sedimentation rate; LUSC cis rs12472274 0.941 rs4663861 chr2:239105203 C/T cg17459225 chr2:239074497 NA 0.63 10.03 0.48 7.08e-21 Phospholipid levels (plasma); LUSC cis rs453301 0.686 rs6748 chr8:8890802 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.5 -0.38 5.64e-13 Joint mobility (Beighton score); LUSC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg18252515 chr7:66147081 NA -1.23 -13.78 -0.6 1.62e-34 Diabetic kidney disease; LUSC cis rs10743315 0.643 rs16915128 chr12:19304286 G/T cg02471346 chr12:19282374 PLEKHA5 -0.68 -6.69 -0.34 9.42e-11 Gut microbiota (bacterial taxa); LUSC cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.55 -0.34 2.12e-10 Monocyte percentage of white cells; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg00149659 chr3:10157352 C3orf10 0.99 14.17 0.61 5.01e-36 Alzheimer's disease; LUSC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg22800045 chr5:56110881 MAP3K1 -0.6 -8.46 -0.42 8.76e-16 Initial pursuit acceleration; LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg15242686 chr22:24348715 GSTTP1 0.4 6.16 0.32 2.08e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3820928 0.845 rs13419076 chr2:227873028 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.61 -0.38 2.81e-13 Pulmonary function; LUSC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg15445000 chr17:37608096 MED1 -0.39 -6.77 -0.35 5.69e-11 Glomerular filtration rate (creatinine); LUSC cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg17845761 chr1:175162550 KIAA0040 -0.31 -5.95 -0.31 6.59e-9 Alcohol dependence; LUSC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg22963979 chr7:1858916 MAD1L1 -0.54 -8.28 -0.41 2.98e-15 Bipolar disorder and schizophrenia; LUSC cis rs3540 0.554 rs12443252 chr15:91064690 C/T cg10434728 chr15:90938212 IQGAP1 -0.46 -9.42 -0.46 7.61e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12995849 0.905 rs12712218 chr2:106451751 G/T cg14210321 chr2:106509881 NCK2 -0.39 -5.82 -0.3 1.36e-8 Addiction; LUSC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg09359103 chr1:154839909 KCNN3 0.72 17.2 0.69 6.02e-48 Prostate cancer; LUSC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg22535103 chr8:58192502 C8orf71 -0.84 -10.15 -0.49 2.92e-21 Developmental language disorder (linguistic errors); LUSC cis rs8072100 0.727 rs4794052 chr17:45769236 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.4 -6.19 -0.32 1.77e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs950169 0.881 rs62029596 chr15:84955434 A/G cg12863693 chr15:85201151 NMB 0.36 7.06 0.36 9.44e-12 Schizophrenia; LUSC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg15448220 chr1:150897856 SETDB1 0.38 5.66 0.3 3.19e-8 Tonsillectomy; LUSC cis rs73110464 0.609 rs727266 chr12:53356411 C/T cg14581129 chr12:53358946 NA -0.71 -9.83 -0.47 3.26e-20 Cancer (pleiotropy); LUSC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg26750617 chr12:132293702 NA -0.36 -5.72 -0.3 2.37e-8 Migraine; LUSC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 5.9e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4474465 0.688 rs10899553 chr11:78265210 A/G cg27205649 chr11:78285834 NARS2 0.52 6.12 0.32 2.64e-9 Alzheimer's disease (survival time); LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg02018176 chr4:1364513 KIAA1530 0.75 13.67 0.6 4.11e-34 Longevity; LUSC cis rs2357013 0.725 rs13426096 chr2:53206582 A/G cg07782112 chr2:53107842 NA 0.38 6.0 0.31 4.99e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs4919694 1.000 rs3740394 chr10:104634474 A/G cg04362960 chr10:104952993 NT5C2 1.14 12.61 0.57 4.36e-30 Arsenic metabolism; LUSC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.68 0.39 1.77e-13 Parkinson's disease; LUSC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.89 -0.35 2.82e-11 Breast cancer; LUSC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg22920501 chr2:26401640 FAM59B -0.73 -10.19 -0.49 2.06e-21 Gut microbiome composition (summer); LUSC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg22638593 chr5:131593259 PDLIM4 0.38 5.81 0.3 1.44e-8 Breast cancer; LUSC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg02187348 chr16:89574699 SPG7 0.6 9.46 0.46 5.8e-19 Multiple myeloma (IgH translocation); LUSC cis rs6964587 0.967 rs28399886 chr7:91638451 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.78 0.3 1.69e-8 Breast cancer; LUSC cis rs3782089 1.000 rs11602375 chr11:65296540 C/T cg00206168 chr11:65308501 LTBP3 1.32 8.84 0.44 5.6e-17 Height; LUSC trans rs8002861 0.664 rs9533662 chr13:44435988 T/A cg12856521 chr11:46389249 DGKZ 0.43 6.44 0.33 4.28e-10 Leprosy; LUSC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg17330251 chr7:94953956 PON1 -0.37 -5.96 -0.31 6.32e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg02807482 chr3:125708958 NA -0.52 -6.5 -0.33 2.98e-10 Blood pressure (smoking interaction); LUSC cis rs1886644 0.700 rs10493758 chr1:85349184 C/T cg08479277 chr1:85350632 LPAR3 0.37 6.27 0.32 1.09e-9 Glucose homeostasis traits; LUSC cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg13256891 chr4:100009986 ADH5 0.51 7.03 0.36 1.21e-11 Smoking initiation; LUSC cis rs4343996 1.000 rs4298408 chr7:3358731 T/C cg21248987 chr7:3385318 SDK1 -0.38 -6.45 -0.33 3.93e-10 Motion sickness; LUSC cis rs10193935 0.901 rs222469 chr2:42640235 T/C cg27598129 chr2:42591480 NA -0.62 -8.36 -0.42 1.76e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg13798780 chr7:105162888 PUS7 0.56 6.12 0.32 2.55e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg22508957 chr16:3507546 NAT15 -0.41 -6.5 -0.34 2.96e-10 Body mass index (adult); LUSC cis rs1044826 0.597 rs1017468 chr3:139145778 A/G cg00490450 chr3:139108681 COPB2 0.5 7.87 0.4 4.85e-14 Obesity-related traits; LUSC cis rs701145 0.585 rs1727923 chr3:153786303 C/T cg17054900 chr3:154042577 DHX36 -0.73 -7.44 -0.38 8.72e-13 Coronary artery disease; LUSC cis rs921968 0.643 rs598701 chr2:219387005 C/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.32 -0.49 7.34e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg22166914 chr1:53195759 ZYG11B 0.48 7.57 0.38 3.68e-13 Monocyte count; LUSC cis rs62408225 0.962 rs6899623 chr6:90986559 A/G cg06866423 chr6:90926672 BACH2 0.4 5.78 0.3 1.75e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg17179660 chr6:151773299 C6orf211;RMND1 0.44 6.56 0.34 2e-10 Menarche (age at onset); LUSC trans rs61931739 0.534 rs10844816 chr12:34248533 C/A cg13010199 chr12:38710504 ALG10B 0.55 8.44 0.42 9.84e-16 Morning vs. evening chronotype; LUSC cis rs7223966 1.000 rs2665826 chr17:61944924 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.16 0.36 5.11e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs908922 0.676 rs549044 chr1:152514332 C/T cg20991723 chr1:152506922 NA 0.5 9.44 0.46 6.48e-19 Hair morphology; LUSC cis rs8040855 0.794 rs4843024 chr15:85705900 A/G cg04831495 chr15:85060580 GOLGA6L5 0.41 5.94 0.31 7.16e-9 Bulimia nervosa; LUSC cis rs7647973 1.000 rs1464569 chr3:49460350 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.43 0.38 9.31e-13 Menarche (age at onset); LUSC cis rs2777491 0.957 rs8027626 chr15:41711514 T/G cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.48 -0.59 2.36e-33 Ulcerative colitis; LUSC cis rs12928939 0.769 rs12445161 chr16:71741928 C/T cg08717414 chr16:71523259 ZNF19 -0.42 -5.91 -0.31 8.23e-9 Post bronchodilator FEV1; LUSC trans rs61931739 0.534 rs11053020 chr12:34111092 C/G cg13010199 chr12:38710504 ALG10B 0.55 8.38 0.42 1.5e-15 Morning vs. evening chronotype; LUSC cis rs7582720 1.000 rs72932566 chr2:203855342 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 8.37 0.42 1.63e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2797160 1.000 rs1777226 chr6:126017691 C/A cg05901451 chr6:126070800 HEY2 0.57 8.58 0.43 3.59e-16 Endometrial cancer; LUSC cis rs614226 1.000 rs591992 chr12:121019323 T/C cg27489772 chr12:121021490 NA 0.6 7.87 0.4 5.06e-14 Type 1 diabetes nephropathy; LUSC cis rs6496044 0.568 rs2344436 chr15:86074906 C/T cg13263323 chr15:86062960 AKAP13 -0.37 -6.16 -0.32 2.06e-9 Interstitial lung disease; LUSC cis rs71403859 0.504 rs12926413 chr16:71972325 T/C cg08717414 chr16:71523259 ZNF19 -0.56 -5.75 -0.3 2.02e-8 Post bronchodilator FEV1; LUSC cis rs4953076 0.573 rs7593987 chr2:44393532 C/T cg04920474 chr2:44395004 PPM1B -0.64 -8.17 -0.41 6.34e-15 Height; LUSC cis rs3736594 0.802 rs9678824 chr2:27964328 G/C cg27432699 chr2:27873401 GPN1 0.66 9.21 0.45 3.58e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.51 6.38 0.33 5.79e-10 Renal function-related traits (BUN); LUSC cis rs1577917 0.958 rs6454487 chr6:86446868 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.44 6.56 0.34 2.04e-10 Response to antipsychotic treatment; LUSC cis rs2816316 0.848 rs3011685 chr1:192524993 C/T cg02586212 chr1:192544902 RGS1 0.31 5.71 0.3 2.55e-8 Celiac disease; LUSC cis rs344364 0.636 rs344363 chr16:1972548 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -5.69 -0.3 2.78e-8 Glomerular filtration rate in chronic kidney disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07805730 chr1:85156430 SSX2IP -0.43 -6.24 -0.32 1.34e-9 Electrocardiographic conduction measures; LUSC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg20573242 chr4:122745356 CCNA2 0.43 6.65 0.34 1.19e-10 Type 2 diabetes; LUSC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg21361702 chr7:150065534 REPIN1 0.5 6.87 0.35 3.09e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs9443189 0.570 rs72888705 chr6:76403114 A/G cg01950844 chr6:76311363 SENP6 0.68 6.84 0.35 3.85e-11 Prostate cancer; LUSC cis rs225245 0.782 rs321618 chr17:33912404 A/G cg05299278 chr17:33885742 SLFN14 0.31 6.9 0.35 2.68e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9378688 1.000 rs72830184 chr6:2223930 T/C cg12303981 chr6:2244766 GMDS -0.54 -6.31 -0.33 8.88e-10 Caudate nucleus volume; LUSC cis rs193541 0.507 rs1965900 chr5:122082786 T/C cg19077854 chr5:122220652 SNX24 0.26 5.64 0.3 3.56e-8 Glucose homeostasis traits; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg00166722 chr3:10149974 C3orf24 0.58 7.42 0.38 9.7e-13 Alzheimer's disease; LUSC cis rs7264396 0.580 rs6119655 chr20:34412049 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.87 -0.44 4.34e-17 Total cholesterol levels; LUSC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs10464366 0.560 rs12701692 chr7:39135551 A/G cg21665744 chr7:39171113 POU6F2 0.42 6.71 0.34 8.22e-11 IgG glycosylation; LUSC cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg01884057 chr2:25150051 NA 0.47 10.68 0.5 4.12e-23 Body mass index in non-asthmatics; LUSC cis rs500891 0.525 rs1539439 chr6:84078564 C/T cg08257003 chr6:84140564 ME1 -0.35 -8.15 -0.41 7.26e-15 Platelet-derived growth factor BB levels; LUSC cis rs116095464 0.558 rs73029475 chr5:206969 T/C cg22857025 chr5:266934 NA -1.19 -13.96 -0.61 3.19e-35 Breast cancer; LUSC cis rs9399401 0.523 rs171915 chr6:142866845 C/T cg03128060 chr6:142623767 GPR126 0.43 7.34 0.37 1.63e-12 Chronic obstructive pulmonary disease; LUSC cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg25174290 chr11:3078921 CARS 0.6 9.56 0.46 2.69e-19 Longevity; LUSC cis rs4704187 0.663 rs4404659 chr5:74422119 T/C cg03227963 chr5:74354835 NA 0.32 6.9 0.35 2.6e-11 Response to amphetamines; LUSC trans rs11098499 0.863 rs34868248 chr4:120442430 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.61 0.34 1.51e-10 Corneal astigmatism; LUSC cis rs7829975 0.509 rs2945269 chr8:8115578 G/C cg06636001 chr8:8085503 FLJ10661 0.86 15.15 0.64 7.88e-40 Mood instability; LUSC cis rs11997175 0.625 rs11991490 chr8:33595407 T/C ch.8.33884649F chr8:33765107 NA 0.41 6.51 0.34 2.81e-10 Body mass index; LUSC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11890956 chr21:40555474 PSMG1 1.04 21.37 0.76 1.82e-64 Cognitive function; LUSC trans rs7824557 0.628 rs3779891 chr8:11183505 G/A cg06636001 chr8:8085503 FLJ10661 0.42 6.14 0.32 2.37e-9 Retinal vascular caliber; LUSC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg05802129 chr4:122689817 NA -0.49 -8.72 -0.43 1.33e-16 Type 2 diabetes; LUSC trans rs1532331 0.966 rs6451674 chr5:43110754 C/T cg02477305 chr13:23993013 SACS 0.34 6.02 0.31 4.48e-9 Menarche (age at onset); LUSC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg03388025 chr16:89894329 SPIRE2 0.3 6.15 0.32 2.16e-9 Vitiligo; LUSC cis rs72781680 0.898 rs55841168 chr2:24007926 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg22618164 chr12:122356400 WDR66 0.63 9.22 0.45 3.36e-18 Mean corpuscular volume; LUSC cis rs6424115 0.931 rs11800561 chr1:24164398 T/G cg15997130 chr1:24165203 NA 0.53 8.67 0.43 1.86e-16 Immature fraction of reticulocytes; LUSC cis rs955333 0.685 rs1022403 chr6:154899713 C/G cg20019720 chr6:154832845 CNKSR3 -0.47 -6.67 -0.34 1.07e-10 Diabetic kidney disease; LUSC cis rs637571 0.510 rs10896052 chr11:65579600 C/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.39 -6.83 -0.35 3.95e-11 Eosinophil percentage of white cells; LUSC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg12564285 chr5:131593104 PDLIM4 0.44 8.0 0.4 2.03e-14 Breast cancer; LUSC cis rs1215050 0.716 rs11940331 chr4:99054041 G/C cg05340658 chr4:99064831 C4orf37 0.46 7.29 0.37 2.3e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs250677 1.000 rs36082 chr5:148428844 C/G cg23229984 chr5:148520753 ABLIM3 0.39 5.94 0.31 7.12e-9 Breast cancer; LUSC cis rs55728055 0.661 rs16989334 chr22:32016092 A/G cg01338084 chr22:32026380 PISD 0.86 6.39 0.33 5.67e-10 Age-related hearing impairment; LUSC cis rs7843479 0.601 rs10101881 chr8:21830158 A/G cg17168535 chr8:21777572 XPO7 0.81 13.63 0.6 6.36e-34 Mean corpuscular volume; LUSC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg02423579 chr7:2872169 GNA12 -0.38 -5.84 -0.3 1.24e-8 Height; LUSC cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg05283184 chr6:79620031 NA -0.57 -11.83 -0.54 3.38e-27 Intelligence (multi-trait analysis); LUSC cis rs2019216 0.500 rs12946184 chr17:21944675 A/C cg22648282 chr17:21454238 C17orf51 -0.5 -6.83 -0.35 4.12e-11 Pelvic organ prolapse; LUSC cis rs6084875 0.840 rs2025118 chr20:4723691 C/T cg26097573 chr20:4721490 PRNT -0.31 -5.76 -0.3 1.87e-8 Systemic lupus erythematosus; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24430517 chr2:242673979 D2HGDH -0.42 -6.37 -0.33 6.23e-10 Electrocardiographic conduction measures; LUSC cis rs2387326 0.629 rs12261739 chr10:129945520 A/G cg16087940 chr10:129947807 NA -0.4 -6.12 -0.32 2.59e-9 Select biomarker traits; LUSC trans rs6448119 0.541 rs17526294 chr4:22061205 C/T cg02770672 chr6:164366085 NA -0.49 -6.03 -0.31 4.3e-9 Rheumatoid arthritis; LUSC cis rs734999 0.545 rs10910106 chr1:2538886 G/T cg18854424 chr1:2615690 NA 0.51 10.18 0.49 2.18e-21 Ulcerative colitis; LUSC cis rs208520 0.526 rs6455072 chr6:66797215 A/G cg07460842 chr6:66804631 NA -1.25 -27.69 -0.83 1.64e-88 Exhaled nitric oxide output; LUSC cis rs9393777 0.545 rs56303243 chr6:26485727 G/A cg12826209 chr6:26865740 GUSBL1 0.67 7.58 0.38 3.45e-13 Intelligence (multi-trait analysis); LUSC cis rs8017423 0.967 rs11624725 chr14:90713609 G/T cg14092571 chr14:90743983 NA 0.38 6.47 0.33 3.59e-10 Mortality in heart failure; LUSC cis rs1728785 1.000 rs1728789 chr16:68595776 C/T cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.45e-10 Ulcerative colitis; LUSC trans rs11764590 0.715 rs55810445 chr7:2103739 C/T cg25206134 chr2:45395956 NA 0.56 6.12 0.32 2.6e-9 Neuroticism; LUSC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.47 6.98 0.36 1.62e-11 Schizophrenia; LUSC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg07936489 chr17:37558343 FBXL20 -0.73 -10.13 -0.48 3.42e-21 Glomerular filtration rate (creatinine); LUSC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.28 -0.45 2.27e-18 Gut microbiome composition (summer); LUSC cis rs61931739 0.500 rs2389269 chr12:34034179 C/T cg06521331 chr12:34319734 NA -0.48 -7.71 -0.39 1.43e-13 Morning vs. evening chronotype; LUSC cis rs2274273 0.686 rs2182207 chr14:55589803 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.51 0.46 3.87e-19 Protein biomarker; LUSC cis rs1784581 0.674 rs3016555 chr6:162391421 T/C cg17173639 chr6:162384350 PARK2 -0.68 -12.1 -0.55 3.28e-28 Itch intensity from mosquito bite; LUSC trans rs2729385 1.000 rs2729385 chr11:57262993 C/T cg14304014 chr19:1625356 TCF3 -0.39 -6.06 -0.31 3.76e-9 Interleukin-18 levels; LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.33 0.62 1.18e-36 Allergic disease (asthma, hay fever or eczema); LUSC trans rs7944735 0.671 rs1228044 chr11:48011180 A/G cg15704280 chr7:45808275 SEPT13 0.55 6.68 0.34 1e-10 Intraocular pressure; LUSC cis rs1808579 0.935 rs12964689 chr18:21116998 A/G cg14672496 chr18:21087552 C18orf8 0.37 6.31 0.33 9.12e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg26597838 chr10:835615 NA 0.78 9.46 0.46 5.75e-19 Eosinophil percentage of granulocytes; LUSC cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg00484396 chr16:3507460 NAT15 -0.46 -6.96 -0.36 1.79e-11 Body mass index (adult); LUSC cis rs17030434 0.954 rs79908936 chr4:154749305 C/T cg14289246 chr4:154710475 SFRP2 -0.56 -7.36 -0.37 1.46e-12 Electrocardiographic conduction measures; LUSC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg09509183 chr1:209979624 IRF6 0.53 6.42 0.33 4.67e-10 Cleft lip with or without cleft palate; LUSC cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg04450456 chr4:17643702 FAM184B 0.39 6.54 0.34 2.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8017423 0.967 rs55667096 chr14:90714798 C/T cg14092571 chr14:90743983 NA -0.36 -5.87 -0.31 1.04e-8 Mortality in heart failure; LUSC cis rs929354 0.742 rs1182396 chr7:157031831 A/C cg17757837 chr7:157058334 UBE3C -0.81 -13.09 -0.58 6.75e-32 Body mass index; LUSC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.95e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10476260 chr2:74682101 INO80B -0.4 -6.04 -0.31 4.21e-9 Electrocardiographic conduction measures; LUSC cis rs10979 0.557 rs9285501 chr6:143915121 G/C cg25407410 chr6:143891975 LOC285740 -0.61 -8.08 -0.4 1.2e-14 Hypospadias; LUSC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg12463550 chr7:65579703 CRCP 0.43 6.1 0.32 2.92e-9 Aortic root size; LUSC cis rs3087591 0.960 rs9898664 chr17:29567152 T/C cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.91 -0.4 3.72e-14 Hip circumference; LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg05283184 chr6:79620031 NA -0.57 -12.04 -0.55 5.59e-28 Intelligence (multi-trait analysis); LUSC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg10755058 chr3:40428713 ENTPD3 0.35 5.97 0.31 5.95e-9 Renal cell carcinoma; LUSC cis rs9457247 0.967 rs86755 chr6:167403108 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs6547741 1.000 rs6718128 chr2:27833752 A/G cg27432699 chr2:27873401 GPN1 -0.79 -14.81 -0.63 1.62e-38 Oral cavity cancer; LUSC cis rs6961069 0.745 rs3211839 chr7:80280462 G/A cg04458919 chr7:80252533 CD36 -0.35 -6.26 -0.32 1.18e-9 Platelet count; LUSC cis rs6430585 1.000 rs6430585 chr2:136506927 A/C cg07169764 chr2:136633963 MCM6 -0.85 -11.87 -0.54 2.38e-27 Corneal structure; LUSC cis rs9976767 0.637 rs2277799 chr21:43824123 G/C cg23042151 chr21:43824109 UBASH3A -0.34 -6.47 -0.33 3.41e-10 Type 1 diabetes; LUSC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg11764359 chr7:65958608 NA 0.73 11.46 0.53 7.24e-26 Aortic root size; LUSC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg03388025 chr16:89894329 SPIRE2 0.31 6.42 0.33 4.56e-10 Vitiligo; LUSC trans rs7937682 0.632 rs11603779 chr11:111781047 A/C cg18187862 chr3:45730750 SACM1L -0.53 -6.51 -0.34 2.69e-10 Primary sclerosing cholangitis; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1941023 0.584 rs950803 chr11:60152563 A/T cg08716584 chr11:60157161 MS4A7 0.62 11.66 0.54 1.43e-26 Congenital heart disease (maternal effect); LUSC cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg01388757 chr2:102091195 RFX8 0.47 7.45 0.38 8.14e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs8014204 0.604 rs12147862 chr14:75384471 C/T cg06637938 chr14:75390232 RPS6KL1 -0.84 -15.15 -0.64 8.06e-40 Caffeine consumption; LUSC cis rs8141529 0.753 rs5752813 chr22:29226570 T/G cg15103426 chr22:29168792 CCDC117 0.58 7.9 0.4 4.21e-14 Lymphocyte counts; LUSC cis rs950027 0.620 rs2461700 chr15:45640627 T/C cg26924012 chr15:45694286 SPATA5L1 0.78 12.38 0.56 3.09e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.95 0.7 6.41e-51 Chronic sinus infection; LUSC cis rs4964805 0.606 rs7312606 chr12:104188385 C/G cg02344784 chr12:104178138 NT5DC3 0.47 9.02 0.44 1.45e-17 Attention deficit hyperactivity disorder; LUSC cis rs1448094 0.967 rs2044617 chr12:86324089 T/C cg02569458 chr12:86230093 RASSF9 0.42 6.86 0.35 3.31e-11 Major depressive disorder; LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg22920501 chr2:26401640 FAM59B 0.83 12.04 0.55 5.72e-28 Gut microbiome composition (summer); LUSC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg03351412 chr1:154909251 PMVK 0.54 8.4 0.42 1.29e-15 Prostate cancer; LUSC cis rs2354432 0.607 rs72692962 chr1:146802674 C/A cg25205988 chr1:146714368 CHD1L -1.03 -9.27 -0.45 2.31e-18 Mitochondrial DNA levels; LUSC cis rs61863818 0.521 rs7923907 chr10:99143499 C/T cg20016023 chr10:99160130 RRP12 0.24 5.77 0.3 1.85e-8 Monocyte percentage of white cells; LUSC cis rs1823874 0.581 rs9920347 chr15:100339331 C/T cg16400843 chr15:100339927 C15orf51 -0.39 -7.3 -0.37 2.12e-12 IgG glycosylation; LUSC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg13902645 chr11:5959945 NA -0.58 -8.16 -0.41 6.88e-15 DNA methylation (variation); LUSC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg17800788 chr1:21766015 NBPF3 0.32 6.14 0.32 2.32e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs72634258 0.786 rs4405150 chr1:8173672 T/C cg00042356 chr1:8021962 PARK7 -0.59 -7.11 -0.36 7.1e-12 Inflammatory bowel disease; LUSC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg00343986 chr7:65444356 GUSB -0.4 -6.33 -0.33 8.11e-10 Aortic root size; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.68 0.39 1.81e-13 Prudent dietary pattern; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21975007 chr6:132128965 ENPP1 -0.5 -6.33 -0.33 7.83e-10 Bipolar disorder and schizophrenia; LUSC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg00074818 chr8:8560427 CLDN23 0.58 9.78 0.47 4.93e-20 Obesity-related traits; LUSC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg14983838 chr19:29218262 NA 0.65 8.85 0.44 5.33e-17 Methadone dose in opioid dependence; LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.31 0.53 2.51e-25 Menopause (age at onset); LUSC cis rs3764021 0.870 rs7973638 chr12:9880441 T/C cg20894963 chr12:9885564 CLECL1 0.33 6.76 0.35 5.99e-11 Type 1 diabetes; LUSC cis rs9341808 0.618 rs6916507 chr6:80862265 T/C cg08355045 chr6:80787529 NA 0.57 9.9 0.48 1.97e-20 Sitting height ratio; LUSC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg09359103 chr1:154839909 KCNN3 -0.7 -16.49 -0.67 3.99e-45 Prostate cancer; LUSC cis rs11166629 0.651 rs7842812 chr8:135641794 T/C cg27224718 chr8:135614730 ZFAT 0.43 7.01 0.36 1.3e-11 Smoking quantity; LUSC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12756686 chr19:29218302 NA 0.68 9.53 0.46 3.35e-19 Methadone dose in opioid dependence; LUSC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg03709012 chr19:19516395 GATAD2A -0.84 -14.34 -0.62 1.1e-36 Tonsillectomy; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg10862848 chr6:42927986 GNMT -0.29 -7.04 -0.36 1.08e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1869026 1.000 rs1869026 chr2:121341281 G/T cg07218647 chr2:121338498 NA -0.27 -5.76 -0.3 1.9e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs8064299 0.597 rs9944506 chr17:72782726 C/G cg25054828 chr17:72772726 NAT9;TMEM104 0.93 19.1 0.72 1.72e-55 Monocyte count; LUSC cis rs870825 0.616 rs10025167 chr4:185649551 A/C cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs80282103 0.867 rs13377037 chr10:1068639 C/T cg08668510 chr10:1095578 IDI1 0.63 6.04 0.31 4.07e-9 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.16e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1538970 1.000 rs4660853 chr1:45849090 C/T cg05343316 chr1:45956843 TESK2 0.62 8.76 0.43 9.69e-17 Platelet count; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg17178900 chr1:205818956 PM20D1 -0.73 -13.26 -0.59 1.55e-32 Monocyte percentage of white cells; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.66 0.76 1.38e-65 Prudent dietary pattern; LUSC trans rs11098499 0.909 rs11723839 chr4:120299673 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.03 0.31 4.41e-9 Corneal astigmatism; LUSC cis rs2580764 0.598 rs6726158 chr2:55239202 G/T cg09592903 chr2:55203963 RTN4 -0.47 -9.45 -0.46 6.2e-19 Mean platelet volume; LUSC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg12311346 chr5:56204834 C5orf35 -0.92 -13.6 -0.6 8.09e-34 Initial pursuit acceleration; LUSC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg14830002 chr1:247616686 OR2B11 -0.54 -7.73 -0.39 1.28e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs950169 0.580 rs62021208 chr15:85196244 G/A cg11189052 chr15:85197271 WDR73 0.49 6.19 0.32 1.79e-9 Schizophrenia; LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs7100689 0.646 rs7899791 chr10:82091950 A/T cg00277334 chr10:82204260 NA -0.58 -8.8 -0.43 7.37e-17 Post bronchodilator FEV1; LUSC cis rs1322512 1.000 rs2800631 chr6:153008631 T/C cg03415253 chr6:152958462 SYNE1 0.38 5.66 0.3 3.19e-8 Tonometry; LUSC cis rs9303401 0.659 rs34351230 chr17:56782555 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs367615 0.679 rs11241021 chr5:108812090 T/G cg17395555 chr5:108820864 NA 0.63 11.29 0.53 2.94e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs11105298 0.891 rs11105309 chr12:89909850 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.55 -0.38 4.12e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs500891 0.525 rs6937193 chr6:84095331 C/T cg08257003 chr6:84140564 ME1 0.34 8.28 0.41 2.92e-15 Platelet-derived growth factor BB levels; LUSC cis rs4363385 0.510 rs11803710 chr1:153053096 C/G cg00922841 chr1:152955080 SPRR1A -0.39 -6.7 -0.34 8.9e-11 Inflammatory skin disease; LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg20887711 chr4:1340912 KIAA1530 -0.59 -9.2 -0.45 4.12e-18 Longevity; LUSC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg23625390 chr15:77176239 SCAPER 0.46 6.93 0.35 2.11e-11 Blood metabolite levels; LUSC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.67 8.17 0.41 6.62e-15 Lung function (FEV1/FVC); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21815882 chr7:26241064 CBX3;HNRNPA2B1 0.44 6.16 0.32 2.13e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg14784868 chr12:69753453 YEATS4 0.82 13.98 0.61 2.89e-35 Blood protein levels; LUSC trans rs9409565 0.826 rs9409778 chr9:97242839 G/A cg05679027 chr9:99775184 HIATL2 -0.46 -6.54 -0.34 2.33e-10 Colorectal cancer (alcohol consumption interaction); LUSC cis rs929596 0.564 rs2741024 chr2:234517745 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.37 -0.33 6.31e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs10465746 0.714 rs12141272 chr1:84434517 C/T cg10977910 chr1:84465055 TTLL7 0.44 6.42 0.33 4.72e-10 Obesity-related traits; LUSC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.75 -0.47 6.13e-20 Gut microbiome composition (summer); LUSC cis rs11792861 0.566 rs1003346 chr9:111815340 C/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.08 0.36 8.54e-12 Menarche (age at onset); LUSC cis rs41271473 0.526 rs2182202 chr1:228733959 G/C cg10167378 chr1:228756711 NA 0.76 9.78 0.47 5.16e-20 Chronic lymphocytic leukemia; LUSC cis rs9325144 0.647 rs10875953 chr12:39050536 G/C cg13010199 chr12:38710504 ALG10B -0.5 -7.61 -0.38 2.85e-13 Morning vs. evening chronotype; LUSC cis rs4845570 1.000 rs7542898 chr1:151753622 T/G cg07092448 chr1:151763213 TDRKH -1.28 -14.49 -0.62 3.02e-37 Coronary artery disease; LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 11.49 0.53 5.54e-26 Alzheimer's disease; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg09033563 chr22:24373618 LOC391322 -0.47 -6.27 -0.32 1.11e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.7 -9.14 -0.45 5.99e-18 Schizophrenia; LUSC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg15369054 chr17:80825471 TBCD 0.41 6.68 0.34 9.88e-11 Breast cancer; LUSC cis rs9811920 0.683 rs10936003 chr3:99667565 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -6.48 -0.33 3.23e-10 Axial length; LUSC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg17261708 chr5:176794207 RGS14 0.33 5.77 0.3 1.8e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg24209194 chr3:40518798 ZNF619 -0.42 -6.01 -0.31 4.78e-9 Renal cell carcinoma; LUSC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg20276088 chr3:133502917 NA -0.42 -6.11 -0.32 2.76e-9 Iron status biomarkers; LUSC trans rs7824557 0.545 rs2572380 chr8:11237477 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.5 -0.34 2.9e-10 Retinal vascular caliber; LUSC cis rs10504073 0.584 rs7820270 chr8:49971395 G/T cg00325661 chr8:49890786 NA 0.66 10.52 0.5 1.46e-22 Blood metabolite ratios; LUSC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg23791538 chr6:167370224 RNASET2 0.42 6.79 0.35 5.12e-11 Crohn's disease; LUSC cis rs76878669 0.561 rs7948058 chr11:66148111 T/A cg24851651 chr11:66362959 CCS 0.38 5.88 0.31 9.79e-9 Educational attainment (years of education); LUSC cis rs6665290 0.901 rs61834001 chr1:227197411 C/T cg10327440 chr1:227177885 CDC42BPA -1.22 -39.91 -0.91 3.76e-129 Myeloid white cell count; LUSC cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.58 -11.44 -0.53 8.75e-26 Monocyte percentage of white cells; LUSC cis rs4654899 0.582 rs4654729 chr1:21224253 T/C cg01072550 chr1:21505969 NA 0.5 7.56 0.38 3.82e-13 Superior frontal gyrus grey matter volume; LUSC cis rs400736 1.000 rs400736 chr1:8078309 T/C cg25007680 chr1:8021821 PARK7 0.57 8.97 0.44 2.1e-17 Response to antidepressants and depression; LUSC cis rs11630290 0.806 rs10519220 chr15:64047120 C/T cg12036633 chr15:63758958 NA 0.65 7.39 0.37 1.19e-12 Iris characteristics; LUSC cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg23649088 chr2:200775458 C2orf69 -0.57 -7.0 -0.36 1.41e-11 Schizophrenia; LUSC cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg15073853 chr19:18549131 ISYNA1 -0.32 -5.94 -0.31 7.1e-9 Breast cancer; LUSC cis rs9788682 0.895 rs3813570 chr15:78832832 T/C cg06917634 chr15:78832804 PSMA4 -0.59 -7.22 -0.37 3.61e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6951245 0.580 rs10257426 chr7:1213694 G/A cg08132940 chr7:1081526 C7orf50 -0.43 -5.75 -0.3 2.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9309473 1.000 rs10184268 chr2:73627044 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -6.14 -0.32 2.33e-9 Metabolite levels; LUSC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.48e-22 Colonoscopy-negative controls vs population controls; LUSC trans rs877282 0.898 rs12359731 chr10:759497 A/G cg13042288 chr15:90349979 ANPEP -0.42 -6.38 -0.33 6.05e-10 Uric acid levels; LUSC cis rs8044995 0.706 rs73612697 chr16:68162016 G/A cg09835421 chr16:68378352 PRMT7 -0.59 -6.21 -0.32 1.59e-9 Schizophrenia; LUSC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6547741 1.000 rs1919125 chr2:27801403 C/G cg12559939 chr2:27858050 GPN1 0.41 6.44 0.33 4.23e-10 Oral cavity cancer; LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg23205692 chr1:25664452 TMEM50A 0.45 6.72 0.34 8.02e-11 Erythrocyte sedimentation rate; LUSC cis rs4594175 0.926 rs10135534 chr14:51617970 C/A cg23942311 chr14:51606299 NA 0.31 5.9 0.31 9.02e-9 Cancer; LUSC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.28e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs10193935 0.901 rs62142599 chr2:42548935 G/A cg27598129 chr2:42591480 NA -0.6 -8.52 -0.42 5.63e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs722599 0.748 rs7145173 chr14:75351647 G/A cg06637938 chr14:75390232 RPS6KL1 -0.42 -6.15 -0.32 2.18e-9 IgG glycosylation; LUSC cis rs9359856 1.000 rs2026650 chr6:90311633 C/G cg13799429 chr6:90582589 CASP8AP2 0.57 6.69 0.34 9.33e-11 Bipolar disorder; LUSC cis rs8060686 0.545 rs9931987 chr16:68256639 G/A cg09835421 chr16:68378352 PRMT7 -0.51 -5.76 -0.3 1.93e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs877282 0.945 rs35342920 chr10:790484 T/C cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs7113850 0.541 rs7129631 chr11:24208560 A/G ch.11.24196551F chr11:24239977 NA 0.95 7.45 0.38 7.8e-13 Bone fracture in osteoporosis; LUSC trans rs12579753 0.879 rs11115010 chr12:82165895 G/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.41 -0.33 5.08e-10 Resting heart rate; LUSC cis rs240764 0.853 rs12660725 chr6:100978570 C/T cg09795085 chr6:101329169 ASCC3 -0.41 -5.91 -0.31 8.42e-9 Neuroticism; LUSC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg22823121 chr1:150693482 HORMAD1 0.58 8.88 0.44 4.04e-17 Tonsillectomy; LUSC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg21984481 chr17:79567631 NPLOC4 -0.57 -11.07 -0.52 1.83e-24 Eye color traits; LUSC cis rs12791968 0.649 rs3802785 chr11:44995441 C/T cg11846598 chr11:44996168 LOC221122 -0.58 -8.11 -0.41 9.49e-15 Inhibitory control; LUSC cis rs10743315 0.557 rs77194694 chr12:19354075 A/G cg02471346 chr12:19282374 PLEKHA5 0.79 6.31 0.33 9e-10 Gut microbiota (bacterial taxa); LUSC cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg14664628 chr15:75095509 CSK -0.8 -12.29 -0.56 6.98e-29 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg13206674 chr6:150067644 NUP43 0.63 10.35 0.49 5.66e-22 Lung cancer; LUSC cis rs11758351 0.789 rs4496782 chr6:26184617 T/C cg23601095 chr6:26197514 HIST1H3D 0.47 5.67 0.3 3.03e-8 Gout;Renal underexcretion gout; LUSC cis rs11122272 0.735 rs2355872 chr1:231478489 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.78 -0.43 8.54e-17 Hemoglobin concentration; LUSC cis rs17095355 1.000 rs11194941 chr10:111744810 A/G cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.48 -0.38 6.7e-13 Biliary atresia; LUSC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg22800045 chr5:56110881 MAP3K1 0.47 6.19 0.32 1.78e-9 Coronary artery disease; LUSC cis rs7123876 0.587 rs72962169 chr11:72365669 C/T cg03713592 chr11:72463424 ARAP1 0.71 7.6 0.38 3.1e-13 Body mass index; LUSC cis rs929596 0.583 rs77070100 chr2:234587847 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.19 -0.37 4.18e-12 Total bilirubin levels in HIV-1 infection; LUSC cis rs6500395 1.000 rs2355297 chr16:48685338 T/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.84 -0.35 3.77e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg06544989 chr22:39130855 UNC84B 0.37 6.41 0.33 5.04e-10 Menopause (age at onset); LUSC trans rs7829975 0.714 rs4840362 chr8:8670082 C/G cg21775007 chr8:11205619 TDH -0.44 -6.4 -0.33 5.33e-10 Mood instability; LUSC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.52 0.46 3.6e-19 Menarche (age at onset); LUSC trans rs7613875 0.600 rs2624832 chr3:50030858 C/T cg21659725 chr3:3221576 CRBN 0.52 8.2 0.41 5.1e-15 Body mass index; LUSC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1801251 0.964 rs7589201 chr2:233724536 A/G cg25237894 chr2:233734115 C2orf82 -0.37 -6.87 -0.35 3.16e-11 Coronary artery disease; LUSC trans rs1728785 1.000 rs1170426 chr16:68603798 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs1997103 0.863 rs2140916 chr7:55403154 A/C cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs34779708 0.931 rs4934711 chr10:35360310 G/A cg03585969 chr10:35415529 CREM 0.59 8.65 0.43 2.24e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7043114 0.544 rs12335553 chr9:95297871 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.56 -0.34 2.07e-10 Height; LUSC cis rs1451375 0.617 rs1376524 chr7:50563582 G/A cg18232548 chr7:50535776 DDC -0.54 -7.61 -0.38 2.83e-13 Malaria; LUSC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs11168618 0.875 rs7972785 chr12:48877056 T/C cg24011408 chr12:48396354 COL2A1 0.38 6.04 0.31 4.05e-9 Adiponectin levels; LUSC cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg23260525 chr10:116636907 FAM160B1 0.48 10.46 0.5 2.49e-22 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9300255 0.510 rs1727323 chr12:123698790 T/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.54 0.46 3.08e-19 Mean platelet volume; LUSC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg22431228 chr1:16359049 CLCNKA -0.47 -9.1 -0.45 8.22e-18 Dilated cardiomyopathy; LUSC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg02782426 chr3:40428986 ENTPD3 0.41 7.79 0.39 8.51e-14 Renal cell carcinoma; LUSC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg18352616 chr4:3374830 RGS12 0.32 6.35 0.33 7.16e-10 Serum sulfate level; LUSC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg00745463 chr17:30367425 LRRC37B -0.72 -8.68 -0.43 1.71e-16 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.49 -0.33 3.06e-10 Lung cancer; LUSC cis rs7246967 0.673 rs62120313 chr19:22877183 G/C cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg18512352 chr11:47633146 NA -0.48 -9.88 -0.48 2.38e-20 Subjective well-being; LUSC trans rs7937682 0.883 rs1613778 chr11:111456105 G/C cg18187862 chr3:45730750 SACM1L 0.53 6.9 0.35 2.6e-11 Primary sclerosing cholangitis; LUSC cis rs2762353 0.935 rs1185567 chr6:25818588 A/G cg15691649 chr6:25882328 NA -0.37 -5.85 -0.3 1.19e-8 Blood metabolite levels; LUSC trans rs6951245 1.000 rs74652290 chr7:1090109 G/A cg13565492 chr6:43139072 SRF -0.57 -6.06 -0.31 3.68e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.31 0.33 8.87e-10 Bipolar disorder; LUSC cis rs6840360 0.571 rs11729136 chr4:152529227 C/A cg22705602 chr4:152727874 NA -0.33 -6.62 -0.34 1.45e-10 Intelligence (multi-trait analysis); LUSC cis rs2652834 0.950 rs2652815 chr15:63401345 T/C cg05507819 chr15:63340323 TPM1 0.66 8.0 0.4 2.11e-14 HDL cholesterol; LUSC cis rs2548003 0.565 rs2554899 chr5:28741116 C/T cg22863700 chr5:28928346 NA 0.47 6.49 0.33 3.1e-10 Hip geometry; LUSC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.48 -7.31 -0.37 2e-12 Personality dimensions; LUSC trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg15704280 chr7:45808275 SEPT13 0.73 8.39 0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); LUSC trans rs12439619 0.768 rs28694364 chr15:82500460 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.47 -6.44 -0.33 4.23e-10 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg03146154 chr1:46216737 IPP 0.53 7.75 0.39 1.09e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs72781680 1.000 rs72796339 chr2:24143063 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs4889855 0.614 rs9898443 chr17:78469357 C/T cg00066239 chr17:78472159 NA 0.42 7.25 0.37 2.83e-12 Fractional excretion of uric acid; LUSC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg08439880 chr3:133502540 NA -0.36 -6.42 -0.33 4.76e-10 Iron status biomarkers; LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg23758822 chr17:41437982 NA 1.03 19.24 0.72 4.93e-56 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07588614 chr3:113604183 GRAMD1C 0.44 6.05 0.31 3.85e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs992157 0.798 rs2382819 chr2:219155909 G/T cg00012203 chr2:219082015 ARPC2 -0.68 -11.04 -0.52 2.26e-24 Colorectal cancer; LUSC cis rs7100689 0.754 rs1934695 chr10:82125230 T/C cg01528321 chr10:82214614 TSPAN14 1.01 15.68 0.65 6.26e-42 Post bronchodilator FEV1; LUSC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.36 -0.37 1.45e-12 Bipolar disorder; LUSC cis rs7107174 1.000 rs2510051 chr11:77981171 A/C cg02023728 chr11:77925099 USP35 0.46 6.65 0.34 1.23e-10 Testicular germ cell tumor; LUSC cis rs10276381 1.000 rs10280937 chr7:28182306 T/C cg23620719 chr7:28220237 JAZF1 0.58 6.27 0.32 1.11e-9 Crohn's disease; LUSC cis rs6076065 0.748 rs6076055 chr20:23333917 G/C cg11657817 chr20:23433608 CST11 0.53 10.68 0.5 4.37e-23 Facial morphology (factor 15, philtrum width); LUSC cis rs2262909 0.925 rs73019900 chr19:22286680 G/A cg11619707 chr19:22235551 ZNF257 0.39 5.86 0.31 1.08e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4664308 0.618 rs6722275 chr2:160893260 C/T cg03641300 chr2:160917029 PLA2R1 -0.49 -8.0 -0.4 2.04e-14 Idiopathic membranous nephropathy; LUSC cis rs921968 0.643 rs563268 chr2:219372912 T/G cg02176678 chr2:219576539 TTLL4 0.6 10.67 0.5 4.48e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.46 -6.89 -0.35 2.71e-11 Menarche (age at onset); LUSC cis rs7937682 0.632 rs1045282 chr11:111754574 A/C cg09085632 chr11:111637200 PPP2R1B 0.93 12.47 0.56 1.46e-29 Primary sclerosing cholangitis; LUSC cis rs7241530 0.569 rs12965943 chr18:75900225 T/G cg14642773 chr18:75888474 NA 0.38 5.73 0.3 2.29e-8 Educational attainment (years of education); LUSC cis rs12931792 0.712 rs2887799 chr16:30163833 G/A cg17640201 chr16:30407289 ZNF48 0.57 8.92 0.44 3.23e-17 Tonsillectomy; LUSC cis rs9322193 0.504 rs7771014 chr6:150205446 T/A cg13206674 chr6:150067644 NUP43 0.43 6.49 0.33 3.13e-10 Lung cancer; LUSC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg17366294 chr4:99064904 C4orf37 0.58 10.39 0.49 4.22e-22 Colonoscopy-negative controls vs population controls; LUSC trans rs6924906 0.655 rs78763763 chr6:82238661 G/A cg15052890 chr17:4636830 MED11;CXCL16 -0.58 -6.12 -0.32 2.57e-9 Blood pressure; LUSC cis rs6964587 1.000 rs1859113 chr7:91679887 T/C cg17063962 chr7:91808500 NA 0.58 9.24 0.45 2.94e-18 Breast cancer; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg07157834 chr1:205819609 PM20D1 0.53 8.74 0.43 1.13e-16 Menarche (age at onset); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg09332974 chr1:113616366 LRIG2 -0.45 -6.79 -0.35 5.26e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg03877680 chr5:178157825 ZNF354A 0.52 6.43 0.33 4.31e-10 Neutrophil percentage of white cells; LUSC cis rs79349575 0.811 rs60708039 chr17:46999373 C/G cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.35e-13 Type 2 diabetes; LUSC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.73 0.35 7.58e-11 Tonsillectomy; LUSC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg04362960 chr10:104952993 NT5C2 0.58 9.12 0.45 7.45e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1023500 0.505 rs2143139 chr22:42614401 G/C cg05082376 chr22:42548792 NA -0.42 -6.46 -0.33 3.64e-10 Schizophrenia; LUSC cis rs3806843 1.000 rs13184940 chr5:140172918 T/C cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.43e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg03060546 chr3:49711283 APEH -0.69 -10.09 -0.48 4.5e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2658782 0.789 rs3020073 chr11:93103830 T/C cg15737290 chr11:93063684 CCDC67 0.62 7.64 0.39 2.34e-13 Pulmonary function decline; LUSC cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg26384229 chr12:38710491 ALG10B 0.92 15.89 0.66 9.31e-43 Heart rate; LUSC cis rs62400317 0.762 rs12190313 chr6:44903902 T/G cg20913747 chr6:44695427 NA -0.47 -7.33 -0.37 1.72e-12 Total body bone mineral density; LUSC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg20933634 chr6:27740509 NA 0.41 5.88 0.31 9.8e-9 Parkinson's disease; LUSC cis rs7937682 1.000 rs9734135 chr11:111536190 G/A cg09085632 chr11:111637200 PPP2R1B -1.1 -17.5 -0.69 3.98e-49 Primary sclerosing cholangitis; LUSC cis rs1865760 0.929 rs2876693 chr6:25954434 C/G cg16482183 chr6:26056742 HIST1H1C 0.46 6.63 0.34 1.34e-10 Height; LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs2243480 0.901 rs778687 chr7:65835819 G/A cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC cis rs17401966 0.540 rs3748581 chr1:10441664 T/C cg17425144 chr1:10567563 PEX14 -0.34 -6.07 -0.32 3.4e-9 Hepatocellular carcinoma; LUSC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg22437258 chr11:111473054 SIK2 0.52 7.44 0.38 8.76e-13 Primary sclerosing cholangitis; LUSC cis rs539096 0.692 rs6686238 chr1:44210253 C/G cg15962314 chr1:44399869 ARTN 0.24 5.73 0.3 2.2e-8 Intelligence (multi-trait analysis); LUSC cis rs4950928 0.823 rs2153101 chr1:203168474 A/T cg17014757 chr1:203156097 CHI3L1 -0.44 -7.64 -0.39 2.31e-13 YKL-40 levels; LUSC cis rs28719689 0.655 rs17063833 chr8:1275384 A/G cg22761795 chr8:1265118 NA 0.53 6.55 0.34 2.18e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs3784262 0.679 rs11071365 chr15:58334126 G/A cg12031962 chr15:58353849 ALDH1A2 -0.38 -6.85 -0.35 3.59e-11 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg14664628 chr15:75095509 CSK -0.49 -7.01 -0.36 1.32e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs709400 0.770 rs7142883 chr14:104066645 G/A cg24130564 chr14:104152367 KLC1 -0.49 -6.97 -0.36 1.72e-11 Body mass index; LUSC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg27170947 chr2:26402098 FAM59B -0.63 -9.18 -0.45 4.77e-18 Gut microbiome composition (summer); LUSC cis rs4700695 0.698 rs416369 chr5:65231058 C/T cg21114390 chr5:65439923 SFRS12 0.51 6.13 0.32 2.54e-9 Facial morphology (factor 19); LUSC cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.27 0.59 1.45e-32 Chronic sinus infection; LUSC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg18404041 chr3:52824283 ITIH1 -0.54 -10.53 -0.5 1.4e-22 Bipolar disorder; LUSC cis rs1003719 0.715 rs58008706 chr21:38540506 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -9.79 -0.47 4.62e-20 Eye color traits; LUSC cis rs9807989 0.708 rs6543124 chr2:102987459 T/A cg03938978 chr2:103052716 IL18RAP 0.33 6.02 0.31 4.57e-9 Asthma; LUSC cis rs11250097 0.549 rs11784897 chr8:11310442 G/A cg21775007 chr8:11205619 TDH -0.56 -7.53 -0.38 4.65e-13 Neuroticism; LUSC trans rs2898290 0.622 rs4840567 chr8:11347625 A/G cg08975724 chr8:8085496 FLJ10661 -0.4 -6.09 -0.32 3.17e-9 Systolic blood pressure; LUSC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg17143192 chr8:8559678 CLDN23 -0.37 -5.76 -0.3 1.89e-8 Mood instability; LUSC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg17252645 chr8:143867129 LY6D 0.38 6.7 0.34 8.75e-11 Urinary tract infection frequency; LUSC cis rs7903847 0.642 rs7903562 chr10:99154782 T/C cg20016023 chr10:99160130 RRP12 -0.32 -8.03 -0.4 1.74e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.86 0.54 2.49e-27 Chronic sinus infection; LUSC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.77e-16 Aortic root size; LUSC cis rs11645898 0.872 rs72791121 chr16:72225294 C/T cg14768367 chr16:72042858 DHODH -0.57 -6.25 -0.32 1.22e-9 Blood protein levels; LUSC cis rs10089 1.000 rs10478803 chr5:127488855 T/C cg19767477 chr5:127420684 SLC12A2 -0.42 -5.8 -0.3 1.53e-8 Ileal carcinoids; LUSC cis rs16976116 0.951 rs9300 chr15:55489065 G/A cg11288833 chr15:55489084 RSL24D1 0.54 6.56 0.34 2.04e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1712517 0.873 rs7916056 chr10:104997914 T/C cg05636881 chr10:105038444 INA -0.4 -6.53 -0.34 2.43e-10 Migraine; LUSC cis rs7582180 0.591 rs62148360 chr2:101006319 C/T cg12002119 chr2:101014098 CHST10 0.36 5.91 0.31 8.32e-9 Intelligence (multi-trait analysis); LUSC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg20302533 chr7:39170763 POU6F2 0.5 8.44 0.42 9.9e-16 IgG glycosylation; LUSC cis rs9788682 0.948 rs34664138 chr15:78831624 T/G cg24631222 chr15:78858424 CHRNA5 0.85 11.44 0.53 8.6e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11098499 0.863 rs3822194 chr4:120471648 A/G cg09307838 chr4:120376055 NA 0.76 11.03 0.52 2.54e-24 Corneal astigmatism; LUSC cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg00071950 chr4:10020882 SLC2A9 0.67 11.21 0.52 5.48e-25 Bone mineral density; LUSC cis rs2404602 0.647 rs4312276 chr15:77164361 T/C cg23625390 chr15:77176239 SCAPER -0.66 -10.06 -0.48 5.81e-21 Blood metabolite levels; LUSC cis rs1670533 1.000 rs7673898 chr4:1056569 C/A cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs2970818 0.831 rs11063187 chr12:4587910 G/T cg11146114 chr12:4671731 NA -0.6 -5.69 -0.3 2.83e-8 Phosphorus levels; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg00106254 chr7:1943704 MAD1L1 0.42 6.08 0.32 3.27e-9 Bipolar disorder and schizophrenia; LUSC cis rs11583043 0.575 rs658861 chr1:101584241 G/A cg11406453 chr1:101602562 NA 0.41 6.95 0.36 1.89e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7512552 0.839 rs1260405 chr1:150304781 A/G cg15654264 chr1:150340011 RPRD2 0.65 10.86 0.51 1.03e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg17330251 chr7:94953956 PON1 -0.37 -5.99 -0.31 5.35e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24826892 chr11:71159390 DHCR7 0.5 6.87 0.35 3.14e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7089973 0.604 rs7904188 chr10:116610271 G/C cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.46e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4919694 0.572 rs12261294 chr10:104934952 C/T cg05855489 chr10:104503620 C10orf26 0.55 6.27 0.32 1.1e-9 Arsenic metabolism; LUSC cis rs73001065 0.818 rs12610185 chr19:19721722 G/A cg03709012 chr19:19516395 GATAD2A 0.89 7.15 0.36 5.34e-12 LDL cholesterol; LUSC trans rs17685 0.753 rs55812043 chr7:75747241 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 19.04 0.72 3.1e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg08847533 chr14:75593920 NEK9 0.85 16.03 0.66 2.81e-43 Height; LUSC cis rs796364 0.694 rs1653299 chr2:201075611 A/G cg23649088 chr2:200775458 C2orf69 0.54 8.3 0.41 2.54e-15 Schizophrenia; LUSC cis rs7264396 1.000 rs224440 chr20:34159447 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -7.68 -0.39 1.73e-13 Total cholesterol levels; LUSC cis rs7264396 0.561 rs66483315 chr20:34573575 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.99 -0.36 1.49e-11 Total cholesterol levels; LUSC cis rs9790314 0.663 rs1599379 chr3:160860665 A/G cg03342759 chr3:160939853 NMD3 -0.44 -7.35 -0.37 1.5e-12 Morning vs. evening chronotype; LUSC cis rs4930103 0.935 rs4930098 chr11:2020955 G/C cg06197492 chr11:2016605 H19 0.42 6.94 0.35 2.08e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs7824557 0.564 rs34389419 chr8:11229319 C/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.47 -0.42 8.12e-16 Retinal vascular caliber; LUSC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg06618935 chr21:46677482 NA -0.37 -7.58 -0.38 3.42e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg24829409 chr8:58192753 C8orf71 -0.48 -5.89 -0.31 9.28e-9 Developmental language disorder (linguistic errors); LUSC cis rs71403859 0.502 rs7195767 chr16:71464943 A/G cg08717414 chr16:71523259 ZNF19 -0.71 -8.34 -0.41 2.04e-15 Post bronchodilator FEV1; LUSC cis rs4555082 0.834 rs4412909 chr14:105759226 T/C cg06808227 chr14:105710500 BRF1 -0.64 -9.74 -0.47 6.74e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs8060686 0.641 rs75450962 chr16:68210868 C/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4631830 0.863 rs3123078 chr10:51524971 A/G cg16070123 chr10:51489643 NA 0.5 8.03 0.4 1.73e-14 Prostate-specific antigen levels; LUSC cis rs68170813 0.559 rs11764448 chr7:106924928 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.79 -0.47 4.7e-20 Coronary artery disease; LUSC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.36 0.46 1.18e-18 Major depressive disorder; LUSC cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg23711669 chr6:146136114 FBXO30 -0.83 -15.09 -0.64 1.3e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs2798269 0.528 rs7322862 chr13:22108134 C/T cg18095732 chr13:22033692 ZDHHC20 0.4 6.26 0.32 1.16e-9 PR segment; LUSC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg13628971 chr7:2884303 GNA12 0.37 5.83 0.3 1.33e-8 Height; LUSC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg01579765 chr21:45077557 HSF2BP -0.54 -11.55 -0.53 3.32e-26 Mean corpuscular volume; LUSC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.64 0.43 2.32e-16 Height; LUSC cis rs4343996 1.000 rs13230698 chr7:3361125 T/C cg21248987 chr7:3385318 SDK1 -0.39 -6.62 -0.34 1.39e-10 Motion sickness; LUSC cis rs611744 0.647 rs647907 chr8:109251374 T/C cg18478394 chr8:109455254 TTC35 0.41 6.29 0.33 9.7e-10 Dupuytren's disease; LUSC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg13206674 chr6:150067644 NUP43 0.63 10.35 0.49 5.66e-22 Lung cancer; LUSC cis rs7432375 0.566 rs835636 chr3:136674500 A/C cg15507776 chr3:136538369 TMEM22 0.45 7.58 0.38 3.43e-13 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs7829975 0.711 rs4481596 chr8:8704330 G/C cg14343924 chr8:8086146 FLJ10661 0.44 6.21 0.32 1.6e-9 Mood instability; LUSC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg25173405 chr17:45401733 C17orf57 0.36 5.74 0.3 2.14e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg07414643 chr4:187882934 NA 0.53 10.06 0.48 5.68e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs10740039 0.766 rs2119917 chr10:62437384 G/A cg18175470 chr10:62150864 ANK3 -0.47 -7.15 -0.36 5.39e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg20283391 chr11:68216788 NA -0.58 -8.21 -0.41 4.97e-15 Total body bone mineral density; LUSC cis rs9325144 0.560 rs11183150 chr12:38674698 A/G cg26384229 chr12:38710491 ALG10B -0.66 -10.25 -0.49 1.26e-21 Morning vs. evening chronotype; LUSC cis rs9611565 0.694 rs79008 chr22:41850500 C/T cg03806693 chr22:41940476 POLR3H -0.95 -13.71 -0.6 3.07e-34 Vitiligo; LUSC cis rs35146811 0.735 rs1727139 chr7:99815367 C/T cg19116668 chr7:99932089 PMS2L1 0.34 5.87 0.31 1.05e-8 Coronary artery disease; LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC cis rs9549367 0.713 rs11620600 chr13:113829090 G/A cg00898013 chr13:113819073 PROZ -0.64 -8.93 -0.44 2.89e-17 Platelet distribution width; LUSC cis rs9788682 1.000 rs34138960 chr15:78831668 A/G cg18825076 chr15:78729989 IREB2 0.47 6.28 0.32 1.07e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg01448562 chr3:133502909 NA -0.58 -8.69 -0.43 1.62e-16 Iron status biomarkers; LUSC cis rs28374715 0.733 rs9568 chr15:41573612 G/T cg18705301 chr15:41695430 NDUFAF1 -0.95 -20.29 -0.74 3.17e-60 Ulcerative colitis; LUSC cis rs11051970 0.679 rs2651377 chr12:32556919 A/C cg24626660 chr12:32551988 NA 0.31 5.73 0.3 2.28e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg15556689 chr8:8085844 FLJ10661 -0.46 -5.83 -0.3 1.29e-8 Obesity-related traits; LUSC cis rs9504361 0.808 rs2277096 chr6:564515 G/T cg15781525 chr6:564561 EXOC2 -0.35 -5.69 -0.3 2.78e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes;Psoriasis;Pit-and-Fissure caries;Eosinophil counts; LUSC cis rs4589502 1.000 rs16950284 chr15:67154184 A/G cg09911534 chr15:67153556 NA 0.68 7.78 0.39 9.27e-14 Lung cancer (smoking interaction); LUSC trans rs4332037 0.575 rs55952733 chr7:2070680 G/A cg25206134 chr2:45395956 NA 0.59 6.91 0.35 2.4e-11 Bipolar disorder; LUSC trans rs6427356 1.000 rs1176555 chr1:157136541 C/G cg23073111 chr11:64073390 ESRRA 0.35 6.37 0.33 6.29e-10 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs2839186 0.843 rs17182671 chr21:47696238 T/C cg12379764 chr21:47803548 PCNT -0.42 -5.91 -0.31 8.39e-9 Testicular germ cell tumor; LUSC cis rs8180040 0.764 rs2132173 chr3:47247060 C/T cg27129171 chr3:47204927 SETD2 -0.69 -11.79 -0.54 4.5e-27 Colorectal cancer; LUSC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg23205692 chr1:25664452 TMEM50A 0.45 6.77 0.35 5.68e-11 Erythrocyte sedimentation rate; LUSC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg16362232 chr11:430036 ANO9 0.64 8.15 0.41 7.37e-15 Body mass index; LUSC cis rs7258465 1.000 rs4808804 chr19:18585325 A/G cg06462663 chr19:18546047 ISYNA1 0.47 7.63 0.39 2.52e-13 Breast cancer; LUSC cis rs2425143 1.000 rs56116518 chr20:34286251 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.32 -0.33 8.56e-10 Blood protein levels; LUSC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg17366294 chr4:99064904 C4orf37 0.56 9.9 0.48 1.95e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg25208724 chr1:156163844 SLC25A44 1.1 26.31 0.82 2.03e-83 Testicular germ cell tumor; LUSC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7312933 0.533 rs3747557 chr12:42717961 G/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.84 -0.35 3.74e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs6541297 1.000 rs1998065 chr1:230286647 T/G cg20703242 chr1:230279135 GALNT2 0.57 8.79 0.43 8.1e-17 Coronary artery disease; LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs12190007 0.514 rs2984462 chr6:169843903 A/T ch.6.169577133F chr6:169835210 NA -0.41 -6.24 -0.32 1.34e-9 Obesity-related traits; LUSC cis rs9513627 0.920 rs2390280 chr13:100208802 A/G cg25919922 chr13:100150906 NA 0.83 6.72 0.35 7.8e-11 Obesity-related traits; LUSC cis rs751728 1.000 rs4711351 chr6:33754592 G/A cg25922239 chr6:33757077 LEMD2 0.53 7.88 0.4 4.68e-14 Crohn's disease; LUSC cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg07606381 chr6:8435919 SLC35B3 -0.72 -12.22 -0.56 1.21e-28 Motion sickness; LUSC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs9300255 0.602 rs1626899 chr12:123708063 A/G cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs1949733 1.000 rs1949733 chr4:8503359 C/T cg13073564 chr4:8508604 NA 0.47 8.76 0.43 1.01e-16 Response to antineoplastic agents; LUSC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs240764 0.595 rs1039033 chr6:101191397 C/T cg09795085 chr6:101329169 ASCC3 -0.41 -5.87 -0.31 1.03e-8 Neuroticism; LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg08219700 chr8:58056026 NA -0.66 -8.11 -0.41 9.82e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg21724239 chr8:58056113 NA 0.67 7.43 0.38 9.33e-13 Developmental language disorder (linguistic errors); LUSC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg00074818 chr8:8560427 CLDN23 -0.58 -9.45 -0.46 6.19e-19 Obesity-related traits; LUSC cis rs7267979 1.000 rs4815421 chr20:25386509 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg19418458 chr7:158789849 NA -0.63 -10.45 -0.5 2.7e-22 Facial morphology (factor 20); LUSC trans rs11098499 0.780 rs7680914 chr4:120563053 A/G cg25214090 chr10:38739885 LOC399744 0.54 7.92 0.4 3.56e-14 Corneal astigmatism; LUSC cis rs4243830 0.850 rs4908915 chr1:6601607 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.86 -10.4 -0.49 3.84e-22 Body mass index; LUSC cis rs2274273 0.624 rs67412516 chr14:55853237 A/T cg04306507 chr14:55594613 LGALS3 0.47 9.43 0.46 6.91e-19 Protein biomarker; LUSC cis rs8062405 0.755 rs4788074 chr16:28593597 A/G cg16576597 chr16:28551801 NUPR1 -0.33 -6.71 -0.34 8.24e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.99 -0.44 1.91e-17 Axial length; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09477292 chr4:6577027 MAN2B2 0.42 6.35 0.33 7e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4363385 0.588 rs6661059 chr1:153027257 A/T cg00922841 chr1:152955080 SPRR1A -0.37 -6.22 -0.32 1.51e-9 Inflammatory skin disease; LUSC trans rs1005277 0.579 rs2023351 chr10:38378814 A/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.64 -0.47 1.47e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7119 0.717 rs12902925 chr15:77819141 T/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.63 -0.34 1.34e-10 Type 2 diabetes; LUSC cis rs921968 0.541 rs2241527 chr2:219537224 A/G cg02176678 chr2:219576539 TTLL4 0.71 13.14 0.58 4.57e-32 Mean corpuscular hemoglobin concentration; LUSC cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.33e-32 Chronic sinus infection; LUSC cis rs6740322 0.696 rs11685054 chr2:43474295 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.49 -6.45 -0.33 3.83e-10 Coronary artery disease; LUSC cis rs1178968 1.000 rs3108462 chr7:72739455 T/C cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.84e-13 Triglyceride levels; LUSC cis rs62158211 1.000 rs62158211 chr2:114106139 G/T cg17784749 chr2:114082611 LOC440839 0.53 6.31 0.33 8.93e-10 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; LUSC cis rs1476679 0.962 rs34995835 chr7:99990364 T/G cg19116668 chr7:99932089 PMS2L1 0.45 8.1 0.41 1.02e-14 Alzheimer's disease (late onset); LUSC cis rs9796 0.870 rs12905926 chr15:41283408 G/A cg18705301 chr15:41695430 NDUFAF1 0.47 8.18 0.41 5.86e-15 Menopause (age at onset); LUSC cis rs7799006 0.606 rs12669625 chr7:2315950 C/T cg12823233 chr7:2316876 SNX8 -0.45 -7.63 -0.39 2.48e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7618501 1.000 rs7372730 chr3:49790682 C/G cg13072238 chr3:49761600 GMPPB -0.4 -6.49 -0.33 3.1e-10 Intelligence (multi-trait analysis); LUSC cis rs7258465 0.897 rs1043327 chr19:18554972 A/G cg06462663 chr19:18546047 ISYNA1 0.44 7.26 0.37 2.8e-12 Breast cancer; LUSC cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.92 -13.39 -0.59 5.04e-33 Chronic sinus infection; LUSC cis rs7786808 0.653 rs4909213 chr7:158202404 G/A cg01191920 chr7:158217561 PTPRN2 -0.52 -10.67 -0.5 4.73e-23 Obesity-related traits; LUSC cis rs6541297 0.878 rs4846905 chr1:230279582 C/T cg20703242 chr1:230279135 GALNT2 -0.56 -8.04 -0.4 1.63e-14 Coronary artery disease; LUSC cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg23711669 chr6:146136114 FBXO30 0.9 17.15 0.68 1.03e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04313601 chr11:10315759 SBF2 -0.4 -6.06 -0.31 3.61e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs2637266 0.902 rs2583056 chr10:78399498 A/G cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.93e-13 Pulmonary function; LUSC cis rs12493885 0.725 rs61791493 chr3:153743573 A/G cg17054900 chr3:154042577 DHX36 -0.7 -7.37 -0.37 1.33e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg23093090 chr10:104574429 C10orf26 0.49 9.29 0.45 2.07e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs11719291 0.831 rs11715177 chr3:48763894 G/A cg00383909 chr3:49044727 WDR6 1.1 9.65 0.47 1.36e-19 Cognitive function; LUSC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18404041 chr3:52824283 ITIH1 -0.53 -10.22 -0.49 1.66e-21 Electroencephalogram traits; LUSC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg16386425 chr10:429943 DIP2C 0.43 6.68 0.34 9.94e-11 Psychosis in Alzheimer's disease; LUSC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg23758822 chr17:41437982 NA 1.02 19.52 0.73 3.82e-57 Menopause (age at onset); LUSC cis rs12618769 0.597 rs2309390 chr2:99114310 T/C cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs9326248 0.510 rs4938332 chr11:116930798 A/G cg20608306 chr11:116969690 SIK3 0.37 6.8 0.35 4.86e-11 Blood protein levels; LUSC cis rs34734847 0.787 rs1814851 chr12:121128633 C/G cg27246729 chr12:121163418 ACADS 0.41 6.47 0.33 3.41e-10 Mean corpuscular volume; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg01238044 chr22:24384105 GSTT1 -0.64 -10.36 -0.49 5.46e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12478601 1.000 rs11888640 chr2:43806382 C/T cg24650394 chr2:43863435 PLEKHH2 0.35 5.75 0.3 2.02e-8 Polycystic ovary syndrome; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13504215 chr3:30648325 TGFBR2 -0.4 -6.02 -0.31 4.62e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11785693 0.862 rs11774044 chr8:4988035 C/G cg26367366 chr8:4980734 NA 0.83 9.67 0.47 1.2e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2762353 0.603 rs4145221 chr6:25763192 A/G cg03264133 chr6:25882463 NA 0.35 5.85 0.3 1.17e-8 Blood metabolite levels; LUSC cis rs9300255 0.539 rs1969355 chr12:123742061 G/A cg05973401 chr12:123451056 ABCB9 0.51 6.97 0.36 1.69e-11 Neutrophil percentage of white cells; LUSC trans rs3733585 0.699 rs62294331 chr4:9959889 A/G cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg18876405 chr7:65276391 NA 0.58 9.41 0.46 8.25e-19 Aortic root size; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg11645453 chr3:52864694 ITIH4 0.29 6.57 0.34 1.91e-10 Electroencephalogram traits; LUSC cis rs12681288 0.550 rs6989880 chr8:957209 A/G cg15309053 chr8:964076 NA 0.42 8.72 0.43 1.33e-16 Schizophrenia; LUSC cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.9 14.74 0.63 3.08e-38 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05655972 chr18:11908331 MPPE1 -0.42 -6.25 -0.32 1.27e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs11764590 0.715 rs9969125 chr7:2088460 C/T cg10840412 chr1:235813424 GNG4 0.51 6.18 0.32 1.87e-9 Neuroticism; LUSC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg21573476 chr21:45109991 RRP1B -0.37 -5.96 -0.31 6.35e-9 Mean corpuscular volume; LUSC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.24 0.41 3.88e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs9625935 0.957 rs35705048 chr22:30270699 T/G cg11564601 chr22:30592435 NA -0.39 -5.85 -0.3 1.17e-8 Tonsillectomy; LUSC cis rs2996428 0.667 rs7545274 chr1:3744261 G/T cg22529645 chr1:3704559 LRRC47 0.34 5.83 0.3 1.3e-8 Red cell distribution width; LUSC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg06238570 chr21:40685208 BRWD1 0.47 7.16 0.36 5.21e-12 Cognitive function; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg08393024 chr5:115177154 ATG12;AP3S1 0.42 5.95 0.31 6.74e-9 Neuroticism; LUSC cis rs2070488 0.775 rs6780349 chr3:38555178 C/T cg24069376 chr3:38537580 EXOG -0.37 -7.36 -0.37 1.44e-12 Electrocardiographic conduction measures; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg14004847 chr7:1930337 MAD1L1 -0.54 -8.03 -0.4 1.72e-14 Bipolar disorder and schizophrenia; LUSC cis rs8177179 0.565 rs4355280 chr3:133468425 A/G cg08048268 chr3:133502702 NA -0.35 -6.73 -0.35 7.25e-11 Iron status biomarkers (transferrin levels); LUSC cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg05855489 chr10:104503620 C10orf26 0.6 9.79 0.47 4.58e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6163 0.588 rs11191392 chr10:104526951 C/A cg04362960 chr10:104952993 NT5C2 0.49 7.37 0.37 1.33e-12 Waist circumference;Hip circumference; LUSC cis rs17401966 0.558 rs4846218 chr1:10452040 G/T cg19773385 chr1:10388646 KIF1B -0.37 -6.58 -0.34 1.8e-10 Hepatocellular carcinoma; LUSC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg03233332 chr7:66118400 NA -0.43 -6.21 -0.32 1.6e-9 Aortic root size; LUSC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg15664640 chr17:80829946 TBCD 0.49 8.75 0.43 1.1e-16 Breast cancer; LUSC trans rs11098499 0.754 rs9991959 chr4:120253773 C/T cg25214090 chr10:38739885 LOC399744 -0.39 -6.11 -0.32 2.72e-9 Corneal astigmatism; LUSC cis rs9926296 0.744 rs460984 chr16:89713174 C/T cg08949735 chr16:89699720 DPEP1 -0.24 -5.79 -0.3 1.63e-8 Vitiligo; LUSC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.49 -7.01 -0.36 1.34e-11 Menarche (age at onset); LUSC cis rs73198271 0.960 rs12155530 chr8:8610964 C/T cg01851573 chr8:8652454 MFHAS1 0.57 8.21 0.41 4.91e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs8114671 0.836 rs6060165 chr20:33619480 A/C cg24642439 chr20:33292090 TP53INP2 -0.42 -6.06 -0.31 3.69e-9 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08377010 chr19:48673515 LIG1 -0.4 -5.96 -0.31 6.35e-9 Electrocardiographic conduction measures; LUSC cis rs9503598 1.000 rs9503598 chr6:3446263 A/G cg00476032 chr6:3446245 SLC22A23 -0.41 -8.35 -0.42 1.85e-15 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs7177699 0.557 rs4389113 chr15:79121739 G/A cg15571903 chr15:79123663 NA -0.34 -6.2 -0.32 1.67e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs77633900 0.772 rs157761 chr15:76796078 C/A cg21673338 chr15:77095150 SCAPER -0.71 -6.05 -0.31 3.86e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg05347473 chr6:146136440 FBXO30 0.41 7.05 0.36 1.06e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs3812049 0.826 rs6860245 chr5:127367998 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.68 -9.08 -0.44 9.73e-18 Lymphocyte counts;Red cell distribution width; LUSC trans rs877282 0.755 rs1769242 chr10:787896 T/C cg13042288 chr15:90349979 ANPEP -0.4 -6.18 -0.32 1.86e-9 Uric acid levels; LUSC trans rs17685 0.712 rs4552844 chr7:75718095 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.78e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg18404041 chr3:52824283 ITIH1 -0.55 -10.53 -0.5 1.4e-22 Electroencephalogram traits; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg23262073 chr20:60523788 NA -0.44 -6.48 -0.33 3.29e-10 Body mass index; LUSC cis rs7615316 0.751 rs2862746 chr3:142042815 C/G cg16271453 chr3:142027066 XRN1 -0.41 -7.23 -0.37 3.29e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11148252 0.740 rs3803264 chr13:52971893 A/G cg02158880 chr13:53174818 NA -0.38 -5.87 -0.31 1.04e-8 Lewy body disease; LUSC cis rs9457247 0.602 rs12208359 chr6:167458455 G/A cg07741184 chr6:167504864 NA 0.49 8.49 0.42 7.09e-16 Crohn's disease; LUSC cis rs7923609 0.967 rs2393986 chr10:65320006 A/T cg01631684 chr10:65280961 REEP3 -0.43 -6.66 -0.34 1.1e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg03233332 chr7:66118400 NA -0.41 -5.98 -0.31 5.79e-9 Aortic root size; LUSC cis rs7011049 1.000 rs72640850 chr8:53836681 A/C cg26025543 chr8:53854495 NA 0.51 6.1 0.32 2.97e-9 Systolic blood pressure; LUSC cis rs778371 0.788 rs778355 chr2:233784749 T/G cg08000102 chr2:233561755 GIGYF2 -0.59 -7.79 -0.39 8.38e-14 Schizophrenia; LUSC cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.75 0.65 3.49e-42 Bladder cancer; LUSC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg14019146 chr3:50243930 SLC38A3 0.31 6.97 0.36 1.73e-11 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg23788917 chr6:8435910 SLC35B3 0.51 7.56 0.38 3.86e-13 Motion sickness; LUSC cis rs2404602 0.669 rs12595313 chr15:76978370 A/G cg23625390 chr15:77176239 SCAPER 0.48 7.24 0.37 3.12e-12 Blood metabolite levels; LUSC trans rs61931739 0.534 rs11053073 chr12:34202412 C/T cg26384229 chr12:38710491 ALG10B 0.74 12.08 0.55 4.07e-28 Morning vs. evening chronotype; LUSC trans rs11098499 0.909 rs11098530 chr4:120413154 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.58 0.34 1.81e-10 Corneal astigmatism; LUSC cis rs1008375 0.966 rs3796812 chr4:17582051 G/A cg04450456 chr4:17643702 FAM184B 0.37 6.26 0.32 1.16e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9640161 0.830 rs12703061 chr7:150062545 T/C cg17279839 chr7:150038598 RARRES2 0.4 6.2 0.32 1.7e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs7824557 0.585 rs2572385 chr8:11208903 G/A cg08975724 chr8:8085496 FLJ10661 0.49 6.89 0.35 2.83e-11 Retinal vascular caliber; LUSC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg16414030 chr3:133502952 NA -0.42 -6.56 -0.34 2.11e-10 Iron status biomarkers; LUSC cis rs240764 0.583 rs11155638 chr6:101203801 T/A cg09795085 chr6:101329169 ASCC3 -0.44 -6.46 -0.33 3.67e-10 Neuroticism; LUSC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg05973401 chr12:123451056 ABCB9 0.56 8.12 0.41 9.21e-15 Platelet count; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg20849893 chr7:64541193 NA -0.5 -7.27 -0.37 2.53e-12 Calcium levels; LUSC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg12927641 chr6:109611667 NA -0.34 -5.81 -0.3 1.49e-8 Reticulocyte fraction of red cells; LUSC cis rs4786125 0.636 rs7192853 chr16:6918241 G/C cg03623568 chr16:6915990 A2BP1 -0.49 -8.23 -0.41 4.15e-15 Heart rate variability traits (SDNN); LUSC cis rs10489202 0.632 rs149912 chr1:167957803 A/T cg24449463 chr1:168025552 DCAF6 -0.76 -12.78 -0.57 1.03e-30 Schizophrenia; LUSC cis rs4812048 1.000 rs6070696 chr20:57597645 A/G cg14073986 chr20:57617431 SLMO2 0.59 7.04 0.36 1.07e-11 Mean platelet volume; LUSC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg01652190 chr22:50026171 C22orf34 -0.31 -6.32 -0.33 8.35e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg06108461 chr20:60628389 TAF4 -0.93 -15.56 -0.65 2.01e-41 Body mass index; LUSC cis rs892961 0.899 rs35217221 chr17:75412385 G/A cg05865280 chr17:75406074 SEPT9 0.45 9.52 0.46 3.71e-19 Airflow obstruction; LUSC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg09877947 chr5:131593287 PDLIM4 0.39 6.08 0.32 3.29e-9 Breast cancer;Mosquito bite size; LUSC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg17971929 chr21:40555470 PSMG1 0.73 11.9 0.55 1.8e-27 Cognitive function; LUSC cis rs8032158 1.000 rs60482539 chr15:56180297 A/C cg02198044 chr15:56286336 NEDD4 -0.36 -5.69 -0.3 2.72e-8 Keloid; LUSC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -6.44 -0.33 4.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11644478 chr21:40555479 PSMG1 -0.91 -17.5 -0.69 4e-49 Cognitive function; LUSC cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg04586622 chr2:25135609 ADCY3 0.43 9.23 0.45 3.12e-18 Body mass index; LUSC cis rs7582180 0.607 rs6725052 chr2:100935817 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.78 0.3 1.76e-8 Intelligence (multi-trait analysis); LUSC cis rs12310956 0.532 rs10844712 chr12:33961022 G/A cg06521331 chr12:34319734 NA -0.47 -7.53 -0.38 4.92e-13 Morning vs. evening chronotype; LUSC cis rs2345546 1 rs2345546 chr16:25427472 C/T cg08360281 chr16:25269390 ZKSCAN2 0.72 8.46 0.42 8.24e-16 Major depression and alcohol dependence; LUSC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg12927641 chr6:109611667 NA -0.34 -5.77 -0.3 1.81e-8 Reticulocyte fraction of red cells; LUSC cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg08999081 chr20:33150536 PIGU -0.54 -10.67 -0.5 4.59e-23 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg05340658 chr4:99064831 C4orf37 0.66 10.86 0.51 9.9899999999999993e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs6696846 0.765 rs61822568 chr1:205081166 C/G cg21643547 chr1:205240462 TMCC2 -0.42 -7.65 -0.39 2.17e-13 Red blood cell count; LUSC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg02951883 chr7:2050386 MAD1L1 -0.44 -7.61 -0.38 2.76e-13 Schizophrenia; LUSC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.76 -0.3 1.96e-8 Lung cancer; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg10488340 chr16:67063589 CBFB 0.41 5.99 0.31 5.37e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg01579765 chr21:45077557 HSF2BP -0.56 -12.06 -0.55 4.92e-28 Mean corpuscular volume; LUSC cis rs11098499 0.754 rs1980026 chr4:120251643 C/A cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg22029157 chr1:209979665 IRF6 0.72 8.77 0.43 9.3e-17 Cleft lip with or without cleft palate; LUSC cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.38 -6.98 -0.36 1.58e-11 Monocyte percentage of white cells; LUSC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 8.19e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs61990749 0.597 rs7142390 chr14:78232880 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.63 6.5 0.34 2.88e-10 Fibroblast growth factor basic levels; LUSC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg22800045 chr5:56110881 MAP3K1 0.59 7.83 0.39 6.39e-14 Type 2 diabetes; LUSC cis rs614226 1.000 rs541126 chr12:120972396 C/T cg01236616 chr12:121019343 POP5 -1.29 -21.04 -0.75 3.7e-63 Type 1 diabetes nephropathy; LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs9814567 0.806 rs9824185 chr3:134324024 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.31 -0.56 5.64e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10266483 0.661 rs608769 chr7:63753161 T/C cg24201672 chr7:64023550 ZNF680 -0.46 -5.83 -0.3 1.32e-8 Response to statin therapy; LUSC cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.7e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2346177 0.967 rs4953374 chr2:46654401 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.58 -9.26 -0.45 2.58e-18 HDL cholesterol; LUSC cis rs7819412 0.875 rs6981523 chr8:11061792 C/T cg21775007 chr8:11205619 TDH -0.54 -7.8 -0.39 8.18e-14 Triglycerides; LUSC cis rs3806843 0.607 rs246060 chr5:140324749 T/C cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg26338869 chr17:61819248 STRADA 0.42 6.06 0.31 3.7e-9 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg00945038 chr17:61921165 SMARCD2 0.53 9.27 0.45 2.31e-18 Prudent dietary pattern; LUSC cis rs9473147 0.503 rs2171086 chr6:47590104 C/T cg02130027 chr6:47444894 CD2AP 0.36 5.85 0.3 1.19e-8 Platelet distribution width;Mean platelet volume; LUSC trans rs10511400 0.618 rs9858566 chr3:119886548 G/C cg02809009 chr19:50354510 PTOV1 -0.67 -6.11 -0.32 2.71e-9 Economic and political preferences (feminism/equality); LUSC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg20891283 chr12:69753455 YEATS4 0.82 15.09 0.64 1.34e-39 Blood protein levels; LUSC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg06544989 chr22:39130855 UNC84B 0.34 5.94 0.31 6.98e-9 Menopause (age at onset); LUSC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg18904891 chr8:8559673 CLDN23 0.61 8.18 0.41 6.04e-15 Obesity-related traits; LUSC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg23172400 chr8:95962367 TP53INP1 -0.3 -5.82 -0.3 1.41e-8 Type 2 diabetes; LUSC cis rs72781680 0.528 rs56258075 chr2:24104256 C/G cg08917208 chr2:24149416 ATAD2B 0.88 10.02 0.48 7.83e-21 Lymphocyte counts; LUSC cis rs1691799 0.777 rs11176145 chr12:66719795 A/G cg16791601 chr12:66731901 HELB 0.58 9.91 0.48 1.86e-20 White blood cell count (basophil); LUSC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg19592336 chr6:28129416 ZNF389 0.46 6.01 0.31 4.81e-9 Depression; LUSC cis rs10875746 0.551 rs2054904 chr12:48724354 C/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.79 -0.3 1.67e-8 Longevity (90 years and older); LUSC cis rs4766566 0.694 rs1362006 chr12:111742222 A/G cg10833066 chr12:111807467 FAM109A 0.55 10.56 0.5 1.06e-22 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC cis rs8018808 0.935 rs12436593 chr14:77928476 C/T cg20045696 chr14:77926864 AHSA1 0.34 5.71 0.3 2.46e-8 Myeloid white cell count; LUSC cis rs62432291 0.681 rs450538 chr6:159659523 A/G cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC cis rs7608623 0.679 rs4665652 chr2:24250023 G/A cg08917208 chr2:24149416 ATAD2B -0.45 -5.95 -0.31 6.63e-9 Obesity-related traits; LUSC cis rs644799 0.542 rs10831418 chr11:95468828 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.64 9.7 0.47 9.23e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.13 0.41 8.35e-15 Prudent dietary pattern; LUSC cis rs1215050 0.791 rs13114823 chr4:98671119 G/A cg05340658 chr4:99064831 C4orf37 -0.46 -7.28 -0.37 2.39e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9473147 0.543 rs7738044 chr6:47469273 A/G cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.71 10.63 0.5 6.27e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs35110281 0.616 rs2236666 chr21:45109856 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 10.8 0.51 1.67e-23 Mean corpuscular volume; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.12 0.41 9.02e-15 Prudent dietary pattern; LUSC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.63 -13.28 -0.59 1.31e-32 Monocyte percentage of white cells; LUSC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg08200582 chr11:442649 ANO9 -0.58 -6.56 -0.34 2.09e-10 Body mass index; LUSC cis rs6062509 0.965 rs6062504 chr20:62348907 A/G cg21849932 chr20:62369462 LIME1 -0.41 -6.1 -0.32 2.94e-9 Prostate cancer; LUSC cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg16447950 chr5:562315 NA -0.55 -7.69 -0.39 1.62e-13 Obesity-related traits; LUSC cis rs68170813 0.559 rs997311 chr7:106953033 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.55 -0.46 2.81e-19 Coronary artery disease; LUSC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg08847533 chr14:75593920 NEK9 0.86 16.11 0.66 1.35e-43 Height; LUSC trans rs1470506 0.529 rs1374395 chr2:77302502 A/T cg21390574 chr3:122675597 SEMA5B -0.3 -6.11 -0.32 2.83e-9 IgG glycosylation; LUSC cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg18681998 chr4:17616180 MED28 0.78 13.8 0.6 1.41e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6754311 0.773 rs309176 chr2:136622216 T/C cg07169764 chr2:136633963 MCM6 -0.6 -8.04 -0.4 1.52e-14 Mosquito bite size; LUSC cis rs1348850 0.632 rs11682717 chr2:178499240 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.24 0.32 1.3e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs17030434 1.000 rs732680 chr4:154725211 G/A cg14289246 chr4:154710475 SFRP2 -0.5 -6.42 -0.33 4.61e-10 Electrocardiographic conduction measures; LUSC cis rs7824557 0.606 rs1435277 chr8:11196970 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.16 0.32 2.05e-9 Retinal vascular caliber; LUSC cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg04518342 chr5:131593106 PDLIM4 0.37 6.77 0.35 5.7e-11 Blood metabolite levels; LUSC trans rs8072100 0.777 rs9914653 chr17:45537395 T/C cg04995722 chr7:26192034 NFE2L3 -0.37 -6.07 -0.32 3.42e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08704250 chr15:31115839 NA 0.4 6.02 0.31 4.47e-9 Huntington's disease progression; LUSC cis rs698813 0.674 rs7590224 chr2:44501209 T/G cg00619915 chr2:44497795 NA -0.53 -7.2 -0.37 3.91e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg02716173 chr4:95372836 PDLIM5 0.44 5.95 0.31 6.85e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg24846343 chr22:24311635 DDTL 0.56 11.47 0.53 6.61e-26 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs9921338 1.000 rs8049173 chr16:11436882 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.67 -0.34 1.07e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs3820928 0.874 rs6706802 chr2:227850776 A/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.61 -0.38 2.91e-13 Pulmonary function; LUSC cis rs4363385 0.747 rs4845504 chr1:152960043 G/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.44 -0.38 8.86e-13 Inflammatory skin disease; LUSC cis rs9815354 0.812 rs11129935 chr3:41985203 A/C cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.72e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03517284 chr6:25882590 NA 0.46 8.71 0.43 1.47e-16 Blood metabolite levels; LUSC cis rs7829975 0.774 rs1039915 chr8:8679614 T/C cg15556689 chr8:8085844 FLJ10661 0.67 10.6 0.5 7.87e-23 Mood instability; LUSC cis rs7223966 1.000 rs7209758 chr17:61913621 C/T cg00945038 chr17:61921165 SMARCD2 0.38 5.7 0.3 2.7e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg11766577 chr21:47581405 C21orf56 0.55 8.64 0.43 2.34e-16 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.48 0.38 6.59e-13 Motion sickness; LUSC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg02487422 chr3:49467188 NICN1 0.47 7.48 0.38 6.58e-13 Resting heart rate; LUSC cis rs634534 0.562 rs642293 chr11:65730217 G/A cg26695010 chr11:65641043 EFEMP2 -0.47 -7.11 -0.36 7.05e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg10729496 chr3:10149963 C3orf24 0.58 7.26 0.37 2.69e-12 Alzheimer's disease; LUSC cis rs362272 0.524 rs7435601 chr4:3369645 A/G cg14583973 chr4:3374767 RGS12 0.34 7.46 0.38 7.62e-13 Serum sulfate level; LUSC cis rs7826238 0.502 rs10503377 chr8:8378422 C/T cg15556689 chr8:8085844 FLJ10661 0.5 6.73 0.35 7.21e-11 Systolic blood pressure; LUSC cis rs7954584 0.635 rs7309024 chr12:122338334 C/T cg10207240 chr12:122356781 WDR66 0.45 6.54 0.34 2.34e-10 Mean corpuscular volume; LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg20887711 chr4:1340912 KIAA1530 0.68 10.58 0.5 9.47e-23 Longevity; LUSC cis rs11785400 1.000 rs10099892 chr8:143734608 C/T cg10596483 chr8:143751796 JRK 0.61 9.4 0.46 9.11e-19 Schizophrenia; LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg22963979 chr7:1858916 MAD1L1 -0.54 -8.03 -0.4 1.64e-14 Bipolar disorder and schizophrenia; LUSC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs765787 0.530 rs7167731 chr15:45510900 T/C cg24006582 chr15:45444508 DUOX1 0.66 9.6 0.47 1.92e-19 Uric acid levels; LUSC cis rs7523050 0.908 rs72697202 chr1:109398704 A/G cg08274380 chr1:109419600 GPSM2 0.92 9.73 0.47 7.24e-20 Fat distribution (HIV); LUSC cis rs738321 0.757 rs2284062 chr22:38544221 A/G cg25457927 chr22:38595422 NA -0.41 -8.02 -0.4 1.86e-14 Breast cancer; LUSC cis rs9715521 0.589 rs11726451 chr4:59852381 A/C cg11281224 chr4:60001000 NA -0.46 -6.58 -0.34 1.83e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg02423579 chr7:2872169 GNA12 -0.41 -6.41 -0.33 5e-10 Height; LUSC cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg01884057 chr2:25150051 NA 0.49 11.49 0.53 5.46e-26 Body mass index; LUSC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg02574844 chr11:5959923 NA -0.4 -6.03 -0.31 4.45e-9 DNA methylation (variation); LUSC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.48 -0.33 3.34e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg09876464 chr15:85330779 ZNF592 0.34 6.02 0.31 4.69e-9 P wave terminal force; LUSC cis rs782590 0.935 rs62165197 chr2:55801812 C/T cg03859395 chr2:55845619 SMEK2 0.87 16.06 0.66 1.99e-43 Metabolic syndrome; LUSC cis rs7615316 0.779 rs9861997 chr3:142060862 T/A cg16271453 chr3:142027066 XRN1 -0.4 -6.96 -0.36 1.82e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg07211511 chr3:129823064 LOC729375 -0.62 -8.21 -0.41 4.72e-15 Blood pressure (smoking interaction); LUSC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg26769984 chr7:1090371 C7orf50 0.58 7.49 0.38 6.03e-13 Bronchopulmonary dysplasia; LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg16325326 chr1:53192061 ZYG11B -0.69 -10.75 -0.51 2.33e-23 Monocyte count; LUSC trans rs1814175 0.817 rs7924619 chr11:49620632 G/A cg15704280 chr7:45808275 SEPT13 -1.1 -23.72 -0.79 1.27e-73 Height; LUSC cis rs7215564 0.908 rs9908112 chr17:78753455 A/G cg23238734 chr17:78661607 RPTOR -0.51 -6.14 -0.32 2.31e-9 Myopia (pathological); LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg04234412 chr22:24373322 LOC391322 0.75 12.97 0.58 1.88e-31 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12997796 0.503 rs34492196 chr2:87021758 T/C cg25203885 chr2:87302643 LOC285074 -0.58 -5.67 -0.3 3.16e-8 Schizophrenia; LUSC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.13e-16 Schizophrenia; LUSC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg04352962 chr1:209979756 IRF6 -0.49 -6.67 -0.34 1.05e-10 Cleft lip with or without cleft palate; LUSC cis rs4343996 0.558 rs11771359 chr7:3412515 C/T cg21248987 chr7:3385318 SDK1 0.37 6.23 0.32 1.38e-9 Motion sickness; LUSC cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg23711669 chr6:146136114 FBXO30 -0.82 -14.68 -0.63 5.49e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC trans rs12579753 0.956 rs7965168 chr12:82184467 C/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.48 -0.33 3.22e-10 Resting heart rate; LUSC cis rs950027 0.549 rs1719250 chr15:45609773 A/G cg04036182 chr15:45458818 NA 0.39 6.56 0.34 2.03e-10 Response to fenofibrate (adiponectin levels); LUSC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg06850241 chr22:41845214 NA 0.3 5.76 0.3 1.88e-8 Vitiligo; LUSC cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg03146154 chr1:46216737 IPP 0.56 8.39 0.42 1.36e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg08470875 chr2:26401718 FAM59B 0.72 9.9 0.48 1.91e-20 Gut microbiome composition (summer); LUSC cis rs548181 1.000 rs548181 chr11:125461709 A/G cg03464685 chr11:125439445 EI24 1.16 14.22 0.61 3.23e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg13683864 chr3:40499215 RPL14 -0.96 -16.33 -0.67 1.72e-44 Renal cell carcinoma; LUSC cis rs459571 0.920 rs460154 chr9:136909309 C/T cg13789015 chr9:136890014 NCRNA00094 0.64 11.83 0.54 3.25e-27 Platelet distribution width; LUSC cis rs4631830 0.720 rs11004422 chr10:51498336 A/G cg16070123 chr10:51489643 NA 0.57 9.38 0.46 1.07e-18 Prostate-specific antigen levels; LUSC cis rs12368653 0.789 rs2270777 chr12:58145156 C/T cg12615879 chr12:58013172 SLC26A10 0.38 8.92 0.44 3.08e-17 Multiple sclerosis; LUSC cis rs9902453 0.845 rs3102559 chr17:28029723 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.48 0.46 4.82e-19 Coffee consumption (cups per day); LUSC trans rs9329221 0.537 rs12678800 chr8:9978940 G/A cg21775007 chr8:11205619 TDH 0.45 6.41 0.33 4.88e-10 Neuroticism; LUSC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg18876405 chr7:65276391 NA -0.54 -8.57 -0.42 3.82e-16 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25716846 chr3:42641998 NKTR -0.41 -6.05 -0.31 3.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11122272 0.735 rs2739515 chr1:231514681 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs8014204 0.570 rs7147721 chr14:75186010 A/G cg06637938 chr14:75390232 RPS6KL1 0.66 11.04 0.52 2.38e-24 Caffeine consumption; LUSC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.67 -6.08 -0.32 3.34e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.64 0.6 5.64e-34 Platelet count; LUSC cis rs11583043 0.708 rs10493942 chr1:101545482 G/A cg11406453 chr1:101602562 NA -0.4 -6.65 -0.34 1.2e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg02931644 chr1:25747376 RHCE 0.34 6.33 0.33 7.69e-10 Erythrocyte sedimentation rate; LUSC cis rs6725041 0.547 rs59096325 chr2:213203853 C/T cg16329650 chr2:213403929 ERBB4 -0.42 -6.67 -0.34 1.09e-10 QT interval (ambient particulate matter interaction); LUSC trans rs4729127 1.000 rs17166229 chr7:94017673 A/G cg19058453 chr19:9879420 ZNF846 0.62 6.17 0.32 1.99e-9 Intelligence; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13848568 chr1:45965625 CCDC163P;MMACHC 0.39 6.0 0.31 5.26e-9 Asthma; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.54 -8.12 -0.41 9.05e-15 Lymphocyte counts; LUSC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg16049864 chr8:95962084 TP53INP1 -0.65 -12.06 -0.55 4.73e-28 Type 2 diabetes; LUSC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg17507749 chr15:85114479 UBE2QP1 0.69 8.71 0.43 1.38e-16 Schizophrenia; LUSC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg13206674 chr6:150067644 NUP43 0.63 10.29 0.49 9.36e-22 Lung cancer; LUSC cis rs9462027 0.628 rs9462030 chr6:34831280 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.88 -0.31 9.86e-9 Systemic lupus erythematosus; LUSC trans rs10506458 0.834 rs17738403 chr12:63389200 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.07 -0.64 1.64e-39 Hemostatic factors and hematological phenotypes; LUSC cis rs73206853 0.841 rs56379265 chr12:110956370 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 7.83e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -5.95 -0.31 6.6e-9 Tonsillectomy; LUSC cis rs12712073 0.837 rs11692867 chr2:100759477 G/A cg22139774 chr2:100720529 AFF3 -0.41 -7.14 -0.36 6.02e-12 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg23711669 chr6:146136114 FBXO30 0.78 14.12 0.61 7.9e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs2073300 0.609 rs3827085 chr20:23356985 A/T cg12062639 chr20:23401060 NAPB 0.97 7.94 0.4 3.07e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs62056376 0.646 rs7210639 chr17:32588628 C/T cg19986872 chr5:131347773 ACSL6 -0.38 -5.94 -0.31 7.01e-9 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs7712401 0.601 rs35847506 chr5:122327108 G/A cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.81 0.39 7.53e-14 Colorectal cancer; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs3820928 0.934 rs1366756 chr2:227772038 G/A cg11843606 chr2:227700838 RHBDD1 -0.52 -7.69 -0.39 1.66e-13 Pulmonary function; LUSC cis rs11585357 1.000 rs72646785 chr1:17603472 G/T cg08277548 chr1:17600880 PADI3 -0.65 -6.71 -0.34 8.45e-11 Hair shape; LUSC cis rs738322 0.553 rs28718653 chr22:38570698 C/A cg25457927 chr22:38595422 NA -0.36 -7.13 -0.36 6.36e-12 Cutaneous nevi; LUSC cis rs12210905 0.925 rs72838238 chr6:26971681 G/A cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08229018 chr4:119274133 PRSS12 -0.44 -5.98 -0.31 5.86e-9 Bipolar disorder and schizophrenia; LUSC cis rs6987853 0.966 rs2923439 chr8:42429122 A/G cg09913449 chr8:42400586 C8orf40 0.49 8.16 0.41 7.05e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs10992471 0.756 rs7848055 chr9:95115492 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.47 -7.84 -0.39 6.11e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs75920871 0.588 rs4548653 chr11:116903316 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.65 -0.34 1.17e-10 Subjective well-being; LUSC cis rs7089973 0.872 rs34683721 chr10:116619849 G/A cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 6.12e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg24531977 chr5:56204891 C5orf35 -0.63 -9.36 -0.46 1.19e-18 Coronary artery disease; LUSC cis rs757110 0.770 rs2051772 chr11:17389850 G/A cg15432903 chr11:17409602 KCNJ11 0.61 10.83 0.51 1.26e-23 Type 2 diabetes; LUSC cis rs1595825 0.891 rs7584475 chr2:198577424 A/C cg19156104 chr2:198669113 PLCL1 -0.44 -5.7 -0.3 2.59e-8 Ulcerative colitis; LUSC cis rs6942756 0.744 rs2718088 chr7:128927020 C/A cg02491457 chr7:128862824 NA 0.49 7.3 0.37 2.13e-12 White matter hyperintensity burden; LUSC cis rs9486715 0.867 rs4240553 chr6:96965324 T/C cg06623918 chr6:96969491 KIAA0776 0.93 17.02 0.68 3.36e-47 Headache; LUSC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg00677455 chr12:58241039 CTDSP2 0.59 8.48 0.42 7.35e-16 Multiple sclerosis; LUSC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg08736216 chr1:53307985 ZYG11A -0.3 -6.19 -0.32 1.79e-9 Monocyte count; LUSC cis rs4363385 0.791 rs11205177 chr1:153002502 G/A cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03744954 chr7:23637556 CCDC126 -0.4 -6.3 -0.33 9.5e-10 Electrocardiographic conduction measures; LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs868036 0.681 rs13329582 chr15:68104608 G/C cg24579218 chr15:68104479 NA -0.39 -6.78 -0.35 5.39e-11 Restless legs syndrome; LUSC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg18240062 chr17:79603768 NPLOC4 0.78 15.3 0.64 2.02e-40 Eye color traits; LUSC cis rs68170813 0.559 rs10953531 chr7:106827867 A/G cg02696742 chr7:106810147 HBP1 0.65 9.75 0.47 6.45e-20 Coronary artery disease; LUSC cis rs11583043 1.000 rs7521424 chr1:101475901 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 6.07 0.32 3.52e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg04398451 chr17:18023971 MYO15A 0.45 7.11 0.36 6.97e-12 Total body bone mineral density; LUSC cis rs6691722 0.506 rs1016209 chr1:24745615 A/G cg18323236 chr1:24743029 NIPAL3 -0.38 -6.56 -0.34 2.05e-10 Response to interferon beta in multiple sclerosis; LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.47 7.53 0.38 4.65e-13 Resistin levels; LUSC cis rs7582180 0.903 rs7607170 chr2:100903008 C/G cg08017756 chr2:100939284 LONRF2 -0.36 -6.15 -0.32 2.24e-9 Intelligence (multi-trait analysis); LUSC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg21918786 chr6:109611834 NA -0.39 -6.7 -0.34 8.78e-11 Reticulocyte fraction of red cells; LUSC cis rs500891 0.504 rs976065 chr6:84092514 C/T cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs2219968 1.000 rs6473085 chr8:78974505 T/A cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg03732007 chr1:2071316 PRKCZ 0.58 10.6 0.5 8.14e-23 Height; LUSC trans rs7769051 1.000 rs9493443 chr6:133121349 C/T cg27275811 chr11:74457193 NA -0.64 -6.22 -0.32 1.51e-9 Type 2 diabetes nephropathy; LUSC trans rs11098499 0.779 rs72918579 chr4:120333222 G/C cg25214090 chr10:38739885 LOC399744 0.54 7.93 0.4 3.3e-14 Corneal astigmatism; LUSC cis rs4319547 0.695 rs55834409 chr12:122862560 C/G cg23029597 chr12:123009494 RSRC2 0.74 9.36 0.46 1.24e-18 Body mass index; LUSC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg23625390 chr15:77176239 SCAPER -0.46 -7.15 -0.36 5.41e-12 Blood metabolite levels; LUSC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg00933542 chr6:150070202 PCMT1 0.3 6.16 0.32 2.06e-9 Lung cancer; LUSC cis rs2067615 0.579 rs10778502 chr12:107090201 T/C cg15890332 chr12:107067104 RFX4 0.33 5.83 0.3 1.33e-8 Heart rate; LUSC cis rs1878931 0.507 rs67218524 chr16:3403057 G/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -7.62 -0.38 2.72e-13 Body mass index (adult); LUSC cis rs4478137 0.931 rs3967762 chr4:164244976 T/C cg06758707 chr4:164254230 NPY1R 0.63 9.92 0.48 1.7e-20 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.5 6.22 0.32 1.45e-9 Gut microbiome composition (summer); LUSC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg17749961 chr2:30669863 LCLAT1 0.71 8.42 0.42 1.09e-15 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg02423579 chr7:2872169 GNA12 -0.38 -5.99 -0.31 5.55e-9 Height; LUSC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg14440974 chr22:39074834 NA -0.36 -5.92 -0.31 7.79e-9 Menopause (age at onset); LUSC cis rs921968 0.643 rs4674320 chr2:219510768 A/G cg02176678 chr2:219576539 TTLL4 0.6 10.98 0.51 3.81e-24 Mean corpuscular hemoglobin concentration; LUSC trans rs1493916 0.905 rs10460051 chr18:31413679 C/T cg13755796 chr4:20253514 NA -0.43 -6.61 -0.34 1.5e-10 Life satisfaction; LUSC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg03709012 chr19:19516395 GATAD2A 0.75 11.59 0.54 2.52e-26 Tonsillectomy; LUSC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC trans rs11098499 0.618 rs6858383 chr4:120296772 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.01 0.4 1.89e-14 Corneal astigmatism; LUSC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg16325326 chr1:53192061 ZYG11B -0.89 -16.66 -0.67 8.4e-46 Monocyte count; LUSC cis rs2346177 0.875 rs12986585 chr2:46644121 T/A cg02822958 chr2:46747628 ATP6V1E2 0.39 6.66 0.34 1.14e-10 HDL cholesterol; LUSC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg16447950 chr5:562315 NA -0.52 -6.88 -0.35 3e-11 Obesity-related traits; LUSC trans rs372883 0.624 rs1153286 chr21:30684383 A/G cg14791747 chr16:20752902 THUMPD1 0.43 6.18 0.32 1.88e-9 Pancreatic cancer; LUSC trans rs11039571 0.544 rs7947811 chr11:48167738 C/T cg03929089 chr4:120376271 NA -0.57 -6.34 -0.33 7.48e-10 D-dimer levels; LUSC cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg13535736 chr9:111863775 C9orf5 -0.42 -6.69 -0.34 9.51e-11 Menarche (age at onset); LUSC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg03526776 chr6:41159608 TREML2 0.29 5.7 0.3 2.62e-8 Alzheimer's disease (late onset); LUSC cis rs11650494 0.710 rs76651802 chr17:47473785 A/G cg08112188 chr17:47440006 ZNF652 0.93 7.93 0.4 3.3e-14 Prostate cancer; LUSC cis rs9311676 0.609 rs11719450 chr3:58456811 A/G cg26110898 chr3:58419937 PDHB -0.39 -6.11 -0.32 2.7e-9 Systemic lupus erythematosus; LUSC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg21918786 chr6:109611834 NA -0.42 -7.28 -0.37 2.36e-12 Reticulocyte fraction of red cells; LUSC cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg03146154 chr1:46216737 IPP 0.5 7.42 0.38 9.7e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs12310956 0.510 rs10844693 chr12:33865197 A/G cg13010199 chr12:38710504 ALG10B -0.45 -6.94 -0.36 2.04e-11 Morning vs. evening chronotype; LUSC trans rs61931739 0.817 rs188588 chr12:34215277 G/A cg13010199 chr12:38710504 ALG10B 0.4 6.25 0.32 1.25e-9 Morning vs. evening chronotype; LUSC cis rs6430585 0.640 rs58301703 chr2:136532225 G/A cg07169764 chr2:136633963 MCM6 1.18 17.48 0.69 4.99e-49 Corneal structure; LUSC cis rs3540 0.597 rs11639150 chr15:91042071 C/G cg22089800 chr15:90895588 ZNF774 -0.64 -9.65 -0.47 1.3e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs1044826 0.642 rs6439860 chr3:139175797 A/G cg00490450 chr3:139108681 COPB2 0.45 6.96 0.36 1.79e-11 Obesity-related traits; LUSC cis rs1784581 0.588 rs7752870 chr6:162422510 T/C cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.05e-20 Itch intensity from mosquito bite; LUSC cis rs8060686 0.641 rs57408712 chr16:68242573 G/C cg05110241 chr16:68378359 PRMT7 -0.56 -6.32 -0.33 8.54e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs853679 0.882 rs4713139 chr6:28092685 C/T cg06606381 chr12:133084897 FBRSL1 -0.67 -7.52 -0.38 5.13e-13 Depression; LUSC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg18230493 chr5:56204884 C5orf35 0.77 12.79 0.57 9.26e-31 Initial pursuit acceleration; LUSC cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg24642439 chr20:33292090 TP53INP2 0.49 7.34 0.37 1.62e-12 Glomerular filtration rate (creatinine); LUSC cis rs4363385 0.818 rs368912 chr1:153016204 C/G cg25856811 chr1:152973957 SPRR3 -0.34 -5.79 -0.3 1.62e-8 Inflammatory skin disease; LUSC cis rs193541 0.632 rs415417 chr5:122322884 G/A cg19077854 chr5:122220652 SNX24 -0.39 -8.35 -0.42 1.88e-15 Glucose homeostasis traits; LUSC cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.17 0.55 1.95e-28 Colorectal cancer; LUSC cis rs96067 0.652 rs274132 chr1:36581978 C/T cg27506609 chr1:36549197 TEKT2 0.62 10.28 0.49 1.01e-21 Corneal structure; LUSC cis rs7089973 0.604 rs2420067 chr10:116590348 A/G cg25233709 chr10:116636983 FAM160B1 0.37 6.59 0.34 1.69e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs929596 0.585 rs2018985 chr2:234648860 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -9.08 -0.44 9.94e-18 Total bilirubin levels in HIV-1 infection; LUSC cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14442939 chr10:27389572 ANKRD26 0.89 7.59 0.38 3.12e-13 Breast cancer; LUSC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg08270630 chr22:50330655 NA -0.44 -6.66 -0.34 1.1e-10 Schizophrenia; LUSC cis rs7178572 0.568 rs11636554 chr15:77608747 C/T cg22256960 chr15:77711686 NA -0.48 -7.57 -0.38 3.57e-13 Type 2 diabetes; LUSC cis rs10140922 0.966 rs10140133 chr14:35819834 C/G cg07166546 chr14:35805898 NA -0.26 -6.15 -0.32 2.19e-9 Hip circumference adjusted for BMI; LUSC cis rs4891159 0.548 rs617823 chr18:74120233 A/G cg24786174 chr18:74118243 ZNF516 0.97 21.18 0.76 1.03e-63 Longevity; LUSC cis rs6967385 0.580 rs3902479 chr7:12329328 T/C cg20607287 chr7:12443886 VWDE 0.37 5.79 0.3 1.64e-8 Response to taxane treatment (placlitaxel); LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg07167872 chr1:205819463 PM20D1 0.88 17.16 0.68 8.75e-48 Menarche (age at onset); LUSC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg18252515 chr7:66147081 NA -0.39 -5.66 -0.3 3.22e-8 Aortic root size; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18976893 chr8:27168292 PTK2B;TRIM35 0.74 6.4 0.33 5.17e-10 Cognitive performance; LUSC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg17264618 chr3:40429014 ENTPD3 0.34 6.92 0.35 2.37e-11 Renal cell carcinoma; LUSC cis rs926938 0.527 rs360679 chr1:115494121 G/T cg12756093 chr1:115239321 AMPD1 0.45 6.81 0.35 4.47e-11 Autism; LUSC cis rs9303401 0.659 rs34468504 chr17:56648277 C/T cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs2749592 1.000 rs2749592 chr10:38258842 A/C cg25427524 chr10:38739819 LOC399744 -0.55 -7.8 -0.39 7.86e-14 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.69 0.34 9.16e-11 Rheumatoid arthritis; LUSC cis rs7247513 0.964 rs4804202 chr19:12718619 T/C cg01871581 chr19:12707946 ZNF490 -0.56 -8.76 -0.43 9.82e-17 Bipolar disorder; LUSC cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg00071950 chr4:10020882 SLC2A9 0.56 9.15 0.45 5.91e-18 Bone mineral density; LUSC trans rs11098499 0.779 rs28495013 chr4:120375831 A/C cg25214090 chr10:38739885 LOC399744 0.55 8.15 0.41 7.34e-15 Corneal astigmatism; LUSC cis rs983392 0.709 rs1820428 chr11:59986333 A/T cg20284999 chr11:59952153 MS4A6A -0.37 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg02423579 chr7:2872169 GNA12 -0.37 -5.89 -0.31 9.44e-9 Height; LUSC cis rs7954584 0.635 rs7137218 chr12:122342877 G/T cg22618164 chr12:122356400 WDR66 0.57 8.59 0.43 3.4e-16 Mean corpuscular volume; LUSC cis rs5769765 0.704 rs138837 chr22:50180714 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.42 6.57 0.34 1.89e-10 Schizophrenia; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg07424592 chr7:64974309 NA -0.43 -6.18 -0.32 1.91e-9 Calcium levels; LUSC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs7178375 0.607 rs34178381 chr15:31222585 G/C cg01738805 chr15:31195741 MTMR15 0.86 7.03 0.36 1.19e-11 Hypertriglyceridemia; LUSC cis rs477692 0.569 rs10764885 chr10:131310207 G/A cg05714579 chr10:131428358 MGMT 0.42 5.99 0.31 5.47e-9 Response to temozolomide; LUSC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.25 -0.32 1.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs7937682 0.814 rs1619652 chr11:111469757 G/A cg19812747 chr11:111475976 SIK2 -0.57 -8.29 -0.41 2.72e-15 Primary sclerosing cholangitis; LUSC cis rs7481584 0.624 rs449466 chr11:3047603 C/T cg08508325 chr11:3079039 CARS 0.36 8.18 0.41 5.9e-15 Calcium levels; LUSC cis rs9303401 0.659 rs12602389 chr17:56779778 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg21770322 chr7:97807741 LMTK2 -0.41 -7.08 -0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6960043 0.502 rs6461145 chr7:15026872 C/T cg19272540 chr7:15055459 NA 0.24 5.69 0.3 2.79e-8 Type 2 diabetes; LUSC cis rs7833986 0.941 rs13278255 chr8:57067975 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.63 9.6 0.47 1.98e-19 Height; LUSC trans rs11148252 0.904 rs9568732 chr13:52993412 A/G cg18335740 chr13:41363409 SLC25A15 -0.61 -10.68 -0.5 4.32e-23 Lewy body disease; LUSC cis rs12044355 0.516 rs2356383 chr1:231742973 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.95 -0.44 2.52e-17 Alzheimer's disease; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC cis rs3008870 0.755 rs2755251 chr1:67496425 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.81 0.57 7.83e-31 Lymphocyte percentage of white cells; LUSC cis rs2274273 0.622 rs11846809 chr14:55401782 T/C cg04306507 chr14:55594613 LGALS3 0.4 8.37 0.42 1.61e-15 Protein biomarker; LUSC cis rs4363385 0.818 rs1415969 chr1:153006448 G/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.44e-8 Inflammatory skin disease; LUSC cis rs7267979 1.000 rs422844 chr20:25445591 T/C cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1538970 0.962 rs2153608 chr1:45813941 C/T cg05343316 chr1:45956843 TESK2 -0.59 -8.07 -0.4 1.24e-14 Platelet count; LUSC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg02423579 chr7:2872169 GNA12 -0.47 -7.03 -0.36 1.16e-11 Height; LUSC cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 7.54 0.38 4.6e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg18876405 chr7:65276391 NA 0.56 8.98 0.44 2e-17 Aortic root size; LUSC cis rs1355223 0.506 rs7947848 chr11:34866220 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.8 -0.35 4.79e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1775715 0.707 rs2799019 chr10:32142850 C/T cg04359828 chr10:32216031 ARHGAP12 0.4 6.91 0.35 2.52e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7937890 1.000 rs7937890 chr11:14396485 C/T cg05501817 chr11:14380813 RRAS2 -0.39 -5.8 -0.3 1.55e-8 Mitochondrial DNA levels; LUSC trans rs71435601 0.574 rs487858 chr2:21400305 G/A cg20757404 chr19:378427 NA 0.37 5.96 0.31 6.28e-9 Cholesterol, total; LUSC trans rs8073060 0.963 rs11080354 chr17:33872407 A/G cg19694781 chr19:47549865 TMEM160 -0.68 -10.11 -0.48 3.87e-21 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs1941687 0.563 rs1565784 chr18:31358491 G/T cg27147174 chr7:100797783 AP1S1 0.53 8.41 0.42 1.2e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs17507216 1.000 rs3850610 chr15:83221392 A/C cg04831495 chr15:85060580 GOLGA6L5 0.46 6.69 0.34 9.39e-11 Excessive daytime sleepiness; LUSC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg11764359 chr7:65958608 NA -0.58 -8.91 -0.44 3.25e-17 Aortic root size; LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg15704280 chr7:45808275 SEPT13 0.98 14.71 0.63 4.22e-38 Coronary artery disease; LUSC cis rs4595586 0.545 rs11615634 chr12:39364704 A/C cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4295623 0.553 rs11250163 chr8:11596437 G/T cg21775007 chr8:11205619 TDH 0.45 6.44 0.33 4.07e-10 Morning vs. evening chronotype; LUSC cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.5 0.38 5.67e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1712517 0.524 rs4917384 chr10:104995788 T/C cg04362960 chr10:104952993 NT5C2 0.53 7.19 0.37 4.29e-12 Migraine; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg02475777 chr4:1388615 CRIPAK -0.41 -6.07 -0.32 3.48e-9 Obesity-related traits; LUSC cis rs8072100 0.575 rs1221385 chr17:45527574 T/G cg08085267 chr17:45401833 C17orf57 -0.52 -7.44 -0.38 8.47e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg00750074 chr16:89608354 SPG7 -0.45 -7.79 -0.39 8.37e-14 Multiple myeloma (IgH translocation); LUSC cis rs9926296 0.744 rs460984 chr16:89713174 C/T cg04287289 chr16:89883240 FANCA -0.43 -6.11 -0.32 2.74e-9 Vitiligo; LUSC cis rs10791097 0.547 rs10791101 chr11:130739133 C/T cg12179176 chr11:130786555 SNX19 0.83 14.38 0.62 7.74e-37 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg25019033 chr10:957182 NA -0.5 -6.37 -0.33 6.33e-10 Eosinophil percentage of granulocytes; LUSC cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.7 0.34 8.79e-11 Glioblastoma; LUSC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg19717773 chr7:2847554 GNA12 -0.38 -6.14 -0.32 2.41e-9 Height; LUSC cis rs2439831 1.000 rs28666488 chr15:43741090 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.23 0.52 5.01e-25 Lung cancer in ever smokers; LUSC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg11629889 chr17:40839022 CNTNAP1 0.51 8.91 0.44 3.35e-17 Colorectal or endometrial cancer; LUSC cis rs2235649 0.663 rs6600168 chr16:1848927 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.43 -5.92 -0.31 7.81e-9 Blood metabolite levels; LUSC cis rs9486719 0.947 rs9398072 chr6:96911304 T/C cg06623918 chr6:96969491 KIAA0776 0.77 9.96 0.48 1.21e-20 Migraine;Coronary artery disease; LUSC cis rs1371867 0.846 rs2919471 chr8:101232701 T/C cg06002616 chr8:101225028 SPAG1 0.47 7.66 0.39 1.97e-13 Atrioventricular conduction; LUSC cis rs4629710 0.592 rs11759926 chr6:131571269 G/T cg12606694 chr6:131520996 AKAP7 0.62 9.36 0.46 1.19e-18 Multiple myeloma (IgH translocation); LUSC cis rs9326248 0.911 rs474339 chr11:117059552 G/A cg20608306 chr11:116969690 SIK3 0.39 6.48 0.33 3.24e-10 Blood protein levels; LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.81e-10 Bipolar disorder; LUSC cis rs6545883 0.931 rs12713438 chr2:61725501 G/A cg15711740 chr2:61764176 XPO1 -0.47 -7.36 -0.37 1.43e-12 Tuberculosis; LUSC cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.37e-18 Monocyte percentage of white cells; LUSC cis rs1153858 1.000 rs7169818 chr15:45640191 G/A cg26924012 chr15:45694286 SPATA5L1 1.11 20.26 0.74 4.5e-60 Homoarginine levels; LUSC cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.66 -0.6 4.79e-34 Chronic sinus infection; LUSC cis rs2708377 0.929 rs61928567 chr12:11304413 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg17719053 chr1:75198211 TYW3;CRYZ -0.39 -5.8 -0.3 1.55e-8 Resistin levels; LUSC cis rs7223966 0.515 rs2727315 chr17:61961458 C/T cg11494091 chr17:61959527 GH2 0.37 6.11 0.32 2.8e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs367615 0.552 rs2416210 chr5:108741137 C/T cg17395555 chr5:108820864 NA -0.46 -7.97 -0.4 2.53e-14 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg05283184 chr6:79620031 NA -0.57 -12.18 -0.55 1.67e-28 Intelligence (multi-trait analysis); LUSC cis rs9291683 0.588 rs4280729 chr4:10013861 C/T cg00071950 chr4:10020882 SLC2A9 0.61 10.31 0.49 8.33e-22 Bone mineral density; LUSC cis rs8060686 0.641 rs7201742 chr16:68099821 T/G cg04539111 chr16:67997858 SLC12A4 -0.41 -5.8 -0.3 1.51e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16150798 chr11:61560092 MIR611;C11orf10;FEN1 -0.43 -6.35 -0.33 6.91e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9291683 0.546 rs13120348 chr4:10053155 C/G cg26043149 chr18:55253948 FECH -0.47 -7.1 -0.36 7.71e-12 Bone mineral density; LUSC cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg03146154 chr1:46216737 IPP -0.51 -7.46 -0.38 7.41e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg07636037 chr3:49044803 WDR6 0.92 14.7 0.63 4.43e-38 Parkinson's disease; LUSC cis rs1348850 0.793 rs13020788 chr2:178480714 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.84 0.3 1.21e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11155671 0.530 rs3823021 chr6:150210999 G/C cg09699651 chr6:150184138 LRP11 0.45 7.17 0.37 4.98e-12 Testicular germ cell tumor; LUSC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg25811766 chr13:21894605 NA 0.64 10.11 0.48 3.98e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC trans rs6089829 0.962 rs3746747 chr20:61667631 T/C cg23505145 chr19:12996616 KLF1 0.65 10.81 0.51 1.47e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.35 6.24 0.32 1.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7824557 0.510 rs1435274 chr8:11235910 G/A cg21775007 chr8:11205619 TDH -0.65 -10.21 -0.49 1.76e-21 Retinal vascular caliber; LUSC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg07701084 chr6:150067640 NUP43 0.57 8.93 0.44 3e-17 Lung cancer; LUSC trans rs853679 0.607 rs13216117 chr6:27938484 A/G cg09904177 chr6:26538194 HMGN4 -0.78 -5.94 -0.31 6.98e-9 Depression; LUSC cis rs7937682 1.000 rs7128353 chr11:111538875 A/G cg22437258 chr11:111473054 SIK2 0.46 6.22 0.32 1.5e-9 Primary sclerosing cholangitis; LUSC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg06238570 chr21:40685208 BRWD1 0.49 7.51 0.38 5.59e-13 Cognitive function; LUSC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg00701064 chr4:6280414 WFS1 0.59 14.24 0.61 2.82e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg17376030 chr22:41985996 PMM1 -0.48 -6.03 -0.31 4.35e-9 Vitiligo; LUSC cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.22 0.37 3.61e-12 Cognitive ability; LUSC cis rs78456975 1.000 rs7584264 chr2:1565555 A/G cg01028140 chr2:1542097 TPO -0.58 -8.07 -0.4 1.31e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13033626 chr12:7342228 PEX5 -0.42 -6.09 -0.32 3.13e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8016982 0.651 rs9806027 chr14:81668707 G/C cg01989461 chr14:81687754 GTF2A1 0.68 11.04 0.52 2.29e-24 Schizophrenia; LUSC cis rs4619890 0.510 rs7680747 chr4:7871623 G/A cg24250820 chr4:7887609 AFAP1 0.36 6.16 0.32 2.11e-9 Glaucoma (primary open-angle); LUSC cis rs453301 0.653 rs7853 chr8:8890814 A/G cg15556689 chr8:8085844 FLJ10661 0.69 11.09 0.52 1.47e-24 Joint mobility (Beighton score); LUSC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg06544989 chr22:39130855 UNC84B 0.35 6.09 0.32 3.03e-9 Menopause (age at onset); LUSC cis rs7799006 1.000 rs7787274 chr7:2275993 G/A cg08027265 chr7:2291960 NA -0.43 -7.5 -0.38 5.9e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7568458 0.846 rs7605975 chr2:85772548 C/T cg23752985 chr2:85803571 VAMP8 0.34 7.07 0.36 8.94e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg07362569 chr17:61921086 SMARCD2 0.37 7.63 0.39 2.5e-13 Prudent dietary pattern; LUSC cis rs208520 0.874 rs208456 chr6:66907942 A/G cg07460842 chr6:66804631 NA -0.96 -12.87 -0.58 4.54e-31 Exhaled nitric oxide output; LUSC cis rs79149102 0.579 rs3812943 chr15:75312715 C/G cg09165964 chr15:75287851 SCAMP5 -0.93 -8.31 -0.41 2.51e-15 Lung cancer; LUSC cis rs929354 0.772 rs2023977 chr7:156996022 C/G cg17757837 chr7:157058334 UBE3C 0.83 13.32 0.59 9.66e-33 Body mass index; LUSC cis rs12050794 0.671 rs2052713 chr15:72520392 G/C cg16672083 chr15:72433130 SENP8 0.47 7.87 0.4 5.09e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg03433033 chr1:76189801 ACADM -0.74 -10.22 -0.49 1.59e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs17270561 0.609 rs6924794 chr6:25735874 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs5758659 0.652 rs129857 chr22:42399686 C/T cg15557168 chr22:42548783 NA 0.33 5.68 0.3 2.98e-8 Cognitive function; LUSC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg24147428 chr11:65409760 SIPA1 -0.55 -7.89 -0.4 4.49e-14 Blood pressure (age interaction); LUSC cis rs7520050 0.807 rs72688483 chr1:46149209 A/G cg06784218 chr1:46089804 CCDC17 0.31 6.02 0.31 4.56e-9 Red blood cell count;Reticulocyte count; LUSC trans rs459571 0.959 rs455381 chr9:136905577 C/A cg10765909 chr12:53715428 AAAS -0.43 -6.19 -0.32 1.75e-9 Platelet distribution width; LUSC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg18876405 chr7:65276391 NA 0.76 13.53 0.59 1.5e-33 Aortic root size; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.03 -0.31 4.23e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg17971929 chr21:40555470 PSMG1 -0.51 -7.56 -0.38 3.84e-13 Menarche (age at onset); LUSC cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg24642439 chr20:33292090 TP53INP2 0.47 7.09 0.36 8.29e-12 Glomerular filtration rate (creatinine); LUSC cis rs72960926 0.744 rs72964203 chr6:74858552 T/C cg03266952 chr6:74778945 NA -0.85 -7.25 -0.37 2.94e-12 Metabolite levels (MHPG); LUSC cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg08999081 chr20:33150536 PIGU 0.52 10.44 0.5 2.89e-22 Glomerular filtration rate (creatinine); LUSC cis rs7582180 0.606 rs10174145 chr2:100932488 T/C cg08017756 chr2:100939284 LONRF2 -0.44 -8.26 -0.41 3.38e-15 Intelligence (multi-trait analysis); LUSC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg13770153 chr20:60521292 NA -0.41 -5.89 -0.31 9.33e-9 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20094282 chr17:79369258 NA -0.46 -6.92 -0.35 2.33e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg13047869 chr3:10149882 C3orf24 -0.54 -7.3 -0.37 2.17e-12 Alzheimer's disease; LUSC cis rs1065656 0.619 rs2492883 chr16:1902105 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.41 -5.97 -0.31 6.02e-9 Insulin-like growth factors; LUSC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.65e-8 Diabetic kidney disease; LUSC cis rs4925114 0.568 rs9900803 chr17:17650978 C/T cg09796270 chr17:17721594 SREBF1 -0.43 -7.46 -0.38 7.37e-13 Body mass index; LUSC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.12 15.13 0.64 9.18e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2120243 0.874 rs1840680 chr3:157156029 A/G cg01018701 chr3:157155998 VEPH1;PTX3 0.4 6.57 0.34 1.96e-10 Hepatocellular carcinoma in hepatitis B infection; LUSC cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg05347473 chr6:146136440 FBXO30 0.47 8.05 0.4 1.46e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7639513 0.767 rs13060705 chr3:12710016 C/A cg23032965 chr3:12705835 RAF1 0.76 11.48 0.53 6.24e-26 Itch intensity from mosquito bite; LUSC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg23711669 chr6:146136114 FBXO30 0.88 16.13 0.66 1.12e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs10435719 0.638 rs67146188 chr8:11782433 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.37 -0.33 6.25e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs9329221 0.537 rs12678800 chr8:9978940 G/A cg15556689 chr8:8085844 FLJ10661 0.54 8.18 0.41 6.04e-15 Neuroticism; LUSC cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg01119278 chr6:110721349 DDO -0.49 -8.81 -0.43 6.81e-17 Platelet distribution width; LUSC cis rs59698941 0.550 rs11748063 chr5:132200943 C/T cg14825688 chr5:132208181 LEAP2 -0.4 -6.05 -0.31 3.91e-9 Apolipoprotein A-IV levels; LUSC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg05802129 chr4:122689817 NA -0.52 -8.67 -0.43 1.96e-16 Type 2 diabetes; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.89 -12.07 -0.55 4.5e-28 Platelet count; LUSC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg06637938 chr14:75390232 RPS6KL1 -0.51 -7.95 -0.4 2.89e-14 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08817937 chr21:33651471 C21orf45 -0.42 -6.22 -0.32 1.48e-9 Electrocardiographic conduction measures; LUSC cis rs4969178 0.965 rs3817295 chr17:76394526 T/A cg05887092 chr17:76393375 PGS1 0.52 9.5 0.46 4.27e-19 HDL cholesterol levels; LUSC cis rs10761482 0.861 rs2061492 chr10:62104016 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs6977660 0.652 rs10267417 chr7:19843797 C/T cg05791153 chr7:19748676 TWISTNB 0.68 6.63 0.34 1.39e-10 Thyroid stimulating hormone; LUSC cis rs6736093 0.966 rs11674226 chr2:112698388 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.9 -0.31 8.73e-9 Coronary artery disease; LUSC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg15839431 chr19:19639596 YJEFN3 -0.42 -5.87 -0.31 1.04e-8 Tonsillectomy; LUSC trans rs1728785 0.901 rs12929568 chr16:68596689 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.57 0.38 3.56e-13 Ulcerative colitis; LUSC cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.64 0.5 5.92e-23 Bladder cancer; LUSC cis rs739496 0.542 rs12423926 chr12:111781055 C/T cg10833066 chr12:111807467 FAM109A -0.6 -11.26 -0.52 3.73e-25 Platelet count; LUSC cis rs10927875 0.619 rs12121764 chr1:16138059 A/T cg22431228 chr1:16359049 CLCNKA 0.33 6.89 0.35 2.71e-11 Dilated cardiomyopathy; LUSC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg16624210 chr5:671434 TPPP 0.49 6.39 0.33 5.59e-10 Obesity-related traits; LUSC cis rs68170813 0.559 rs78079372 chr7:106934548 T/G cg02696742 chr7:106810147 HBP1 -0.65 -9.98 -0.48 1.09e-20 Coronary artery disease; LUSC cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs7527798 0.571 rs7531923 chr1:207833336 T/G cg09232269 chr1:207846808 CR1L -0.29 -6.15 -0.32 2.16e-9 Erythrocyte sedimentation rate; LUSC cis rs9815354 0.627 rs115971784 chr3:42016146 T/C cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs7312933 0.558 rs7305397 chr12:42850058 T/C cg01256987 chr12:42539512 GXYLT1 -0.4 -7.24 -0.37 3.07e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4730250 0.670 rs9641380 chr7:106868151 C/G cg02696742 chr7:106810147 HBP1 -0.64 -9.71 -0.47 8.5e-20 Osteoarthritis; LUSC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg10802521 chr3:52805072 NEK4 -0.43 -6.78 -0.35 5.32e-11 Bipolar disorder; LUSC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg12463550 chr7:65579703 CRCP 0.42 5.99 0.31 5.37e-9 Calcium levels; LUSC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg06808227 chr14:105710500 BRF1 -0.7 -10.91 -0.51 6.71e-24 Mean platelet volume;Platelet distribution width; LUSC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg09835421 chr16:68378352 PRMT7 -0.57 -6.38 -0.33 5.76e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs330071 0.500 rs17662123 chr8:9246837 G/A cg14343924 chr8:8086146 FLJ10661 0.44 6.28 0.32 1.03e-9 Acne (severe); LUSC cis rs9811920 0.965 rs10222474 chr3:99862551 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.38 5.72 0.3 2.4e-8 Axial length; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg26220528 chr12:57623348 SHMT2 0.47 7.38 0.37 1.24e-12 Triglycerides; LUSC cis rs911555 0.723 rs12894652 chr14:103926024 A/G cg24130564 chr14:104152367 KLC1 0.44 6.33 0.33 8.02e-10 Intelligence (multi-trait analysis); LUSC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg22857025 chr5:266934 NA -1.16 -16.37 -0.67 1.19e-44 Breast cancer; LUSC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg01475377 chr6:109611718 NA 0.46 8.34 0.42 1.92e-15 Reticulocyte fraction of red cells; LUSC cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg01884057 chr2:25150051 NA -0.46 -10.67 -0.5 4.62e-23 Body mass index; LUSC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7216064 1.000 rs60432293 chr17:65860407 T/C cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs6542838 0.641 rs883773 chr2:99491635 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.08 -0.32 3.32e-9 Fear of minor pain; LUSC cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.57 -7.22 -0.37 3.47e-12 Schizophrenia; LUSC cis rs4906332 0.933 rs34606394 chr14:103915636 G/A cg04998671 chr14:104000505 TRMT61A -0.44 -6.93 -0.35 2.17e-11 Coronary artery disease; LUSC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg04398451 chr17:18023971 MYO15A 0.43 6.75 0.35 6.57e-11 Total body bone mineral density; LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.97 0.31 6.05e-9 Menopause (age at onset); LUSC cis rs35146811 0.735 rs2528900 chr7:99805319 A/G cg22906224 chr7:99728672 NA -0.46 -6.5 -0.34 2.92e-10 Coronary artery disease; LUSC cis rs12908161 1.000 rs11638290 chr15:85227636 C/T cg17173187 chr15:85201210 NMB 0.51 9.66 0.47 1.24e-19 Schizophrenia; LUSC cis rs2439831 1.000 rs2254321 chr15:43707542 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.55 0.42 4.47e-16 Lung cancer in ever smokers; LUSC cis rs950776 0.518 rs56007453 chr15:78826239 T/C cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.31 0.33 8.63e-10 Personality dimensions; LUSC cis rs41271473 0.526 rs12136157 chr1:228703236 T/C cg10167378 chr1:228756711 NA 0.69 8.9 0.44 3.68e-17 Chronic lymphocytic leukemia; LUSC cis rs7107174 1.000 rs2511168 chr11:77965081 T/G cg02023728 chr11:77925099 USP35 0.49 7.15 0.36 5.56e-12 Testicular germ cell tumor; LUSC cis rs7804356 1.000 rs73069507 chr7:26877536 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.58e-9 Type 1 diabetes; LUSC cis rs4664308 0.692 rs4233681 chr2:160960058 T/C cg03641300 chr2:160917029 PLA2R1 -0.62 -10.19 -0.49 2.01e-21 Idiopathic membranous nephropathy; LUSC cis rs77106637 0.932 rs3814730 chr11:72555553 G/A cg03713592 chr11:72463424 ARAP1 0.74 8.55 0.42 4.38e-16 Type 2 diabetes; LUSC cis rs12681287 0.752 rs12681438 chr8:87293089 G/A cg27223183 chr8:87520930 FAM82B -0.46 -5.86 -0.31 1.13e-8 Caudate activity during reward; LUSC cis rs7804356 1.000 rs3801850 chr7:26820577 T/C cg03456212 chr7:26904342 SKAP2 -0.55 -6.49 -0.33 3.17e-10 Type 1 diabetes; LUSC trans rs11098499 0.954 rs2389802 chr4:120325732 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.36 0.33 6.64e-10 Corneal astigmatism; LUSC cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.27 0.56 7.85e-29 Motion sickness; LUSC cis rs243505 1.000 rs243507 chr7:148434600 G/A cg09806900 chr7:148480153 CUL1 -0.49 -6.89 -0.35 2.77e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg27165867 chr14:105738592 BRF1 -0.53 -7.97 -0.4 2.54e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs6840360 1.000 rs28710456 chr4:152667171 T/C cg22705602 chr4:152727874 NA -0.28 -6.07 -0.32 3.49e-9 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg22467129 chr15:76604101 ETFA -0.51 -8.26 -0.41 3.38e-15 Blood metabolite levels; LUSC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg00033643 chr7:134001901 SLC35B4 0.43 6.79 0.35 5.13e-11 Mean platelet volume; LUSC cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.74 0.35 6.76e-11 Educational attainment; LUSC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.45 -0.33 3.84e-10 Total body bone mineral density; LUSC cis rs7267979 1.000 rs6050564 chr20:25344231 G/A cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9303401 0.659 rs7210700 chr17:56668186 G/A cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs6424115 0.867 rs11588187 chr1:24145047 T/A cg15997130 chr1:24165203 NA 0.52 8.45 0.42 9.1e-16 Immature fraction of reticulocytes; LUSC cis rs2692947 0.673 rs1168965 chr2:96787899 C/G cg23100626 chr2:96804247 ASTL -0.31 -7.37 -0.37 1.33e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.8 10.5 0.5 1.74e-22 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20521125 chr10:103912151 NOLC1 -0.46 -6.67 -0.34 1.09e-10 Electrocardiographic conduction measures; LUSC cis rs11048434 0.723 rs12820395 chr12:9137096 T/G cg13575925 chr12:9217583 LOC144571 0.35 6.38 0.33 5.81e-10 Sjögren's syndrome; LUSC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.41 0.64 7.23e-41 Platelet count; LUSC trans rs11098499 0.863 rs2306457 chr4:120472839 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.41 -5.7 -0.3 2.62e-8 Personality dimensions; LUSC cis rs6939532 0.522 rs4712981 chr6:26361430 C/T cg05738196 chr6:26577821 NA -0.41 -5.66 -0.3 3.19e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs10911363 0.659 rs7518244 chr1:183434807 C/T cg09173681 chr1:183549694 NCF2 -0.63 -11.15 -0.52 9.35e-25 Systemic lupus erythematosus; LUSC cis rs911186 0.730 rs2393911 chr6:27057079 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.37 -6.05 -0.31 3.98e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4474465 0.850 rs10793332 chr11:78270020 C/G cg27205649 chr11:78285834 NARS2 0.51 6.08 0.32 3.26e-9 Alzheimer's disease (survival time); LUSC cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg19052272 chr2:3704530 ALLC 0.45 7.37 0.37 1.37e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9640161 0.830 rs3735165 chr7:150068371 T/C cg21361702 chr7:150065534 REPIN1 0.58 9.21 0.45 3.6e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs2404602 0.647 rs907594 chr15:77197745 C/A cg23625390 chr15:77176239 SCAPER -0.64 -9.92 -0.48 1.73e-20 Blood metabolite levels; LUSC cis rs9788682 0.747 rs2938671 chr15:78732754 A/G cg06917634 chr15:78832804 PSMA4 0.48 5.97 0.31 6.07e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11792861 0.926 rs118011482 chr9:111770626 G/C cg05043794 chr9:111880884 C9orf5 -0.38 -7.93 -0.4 3.31e-14 Menarche (age at onset); LUSC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg01341218 chr17:43662625 NA 0.77 11.31 0.53 2.5e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7582720 1.000 rs72934715 chr2:203713280 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs17095355 0.792 rs61881587 chr10:111759710 A/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.31 -0.37 1.96e-12 Biliary atresia; LUSC cis rs500891 0.597 rs4706998 chr6:84167277 A/G cg08257003 chr6:84140564 ME1 0.35 8.43 0.42 1.05e-15 Platelet-derived growth factor BB levels; LUSC trans rs62103177 0.810 rs62103187 chr18:77627633 G/C cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC cis rs17270561 0.609 rs9393659 chr6:25731358 T/C cg16482183 chr6:26056742 HIST1H1C 0.64 9.08 0.44 9.81e-18 Iron status biomarkers; LUSC cis rs6964587 1.000 rs6969536 chr7:91689351 C/G cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1371867 0.875 rs962452 chr8:101331369 G/A cg06636551 chr8:101224915 SPAG1 -0.38 -7.13 -0.36 6.31e-12 Atrioventricular conduction; LUSC trans rs35110281 0.782 rs1584917 chr21:45042365 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.32 0.53 2.26e-25 Mean corpuscular volume; LUSC cis rs7264396 0.623 rs6060504 chr20:34197619 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -7.16 -0.36 5.13e-12 Total cholesterol levels; LUSC cis rs7267979 1.000 rs4815421 chr20:25386509 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs3749237 1.000 rs11920900 chr3:49823024 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.5 6.82 0.35 4.2e-11 Resting heart rate; LUSC cis rs2637266 0.905 rs3923669 chr10:78375047 T/C cg18941641 chr10:78392320 NA 0.38 6.94 0.36 2.04e-11 Pulmonary function; LUSC cis rs5756813 0.754 rs11089854 chr22:38148882 G/A cg06521852 chr22:38141419 TRIOBP 0.42 6.37 0.33 6.26e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs1124376 1.000 rs61138004 chr3:20145855 C/G cg05072819 chr3:20081367 KAT2B 0.69 7.74 0.39 1.19e-13 Bipolar disorder and schizophrenia; LUSC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg02931644 chr1:25747376 RHCE 0.32 5.82 0.3 1.41e-8 Erythrocyte sedimentation rate; LUSC cis rs9322193 0.887 rs4870139 chr6:149896318 T/C cg00933542 chr6:150070202 PCMT1 0.34 6.96 0.36 1.82e-11 Lung cancer; LUSC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg18758796 chr5:131593413 PDLIM4 0.43 7.5 0.38 5.82e-13 Breast cancer; LUSC cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg02153584 chr22:29168773 CCDC117 -0.55 -7.89 -0.4 4.43e-14 Lymphocyte counts; LUSC cis rs1348850 0.914 rs10194648 chr2:178337031 G/A cg22681709 chr2:178499509 PDE11A -0.49 -9.07 -0.44 1.02e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs117623576 0.941 rs211409 chr10:32393213 T/C cg03047570 chr10:32398778 NA 0.74 7.92 0.4 3.45e-14 Anti-saccade response; LUSC cis rs8062405 0.895 rs62036658 chr16:28850371 T/G cg05966235 chr16:28915196 ATP2A1 0.34 5.95 0.31 6.63e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs3820928 0.845 rs7570869 chr2:227878818 A/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.78 -0.39 9.41e-14 Pulmonary function; LUSC cis rs10782582 0.609 rs112205173 chr1:76310100 C/T cg10523679 chr1:76189770 ACADM -0.48 -6.77 -0.35 5.73e-11 Daytime sleep phenotypes; LUSC cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg08564027 chr20:61660810 NA 0.91 17.42 0.69 8.43e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs7561273 0.609 rs2339945 chr2:24348096 G/A cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs7927771 0.524 rs2290851 chr11:47753370 C/T cg20307385 chr11:47447363 PSMC3 -0.44 -6.61 -0.34 1.51e-10 Subjective well-being; LUSC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg11871910 chr12:69753446 YEATS4 0.84 15.2 0.64 5.09e-40 Blood protein levels; LUSC cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg06784218 chr1:46089804 CCDC17 0.56 11.69 0.54 1.05e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs55665837 1.000 rs11023224 chr11:14457739 G/A cg05501817 chr11:14380813 RRAS2 -0.41 -6.51 -0.34 2.72e-10 Vitamin D levels; LUSC cis rs11958404 0.860 rs72818117 chr5:157441130 G/A cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg17724175 chr1:150552817 MCL1 0.32 5.67 0.3 3.05e-8 Melanoma; LUSC cis rs5997397 0.967 rs5752791 chr22:29153547 A/G cg02153584 chr22:29168773 CCDC117 -0.45 -6.91 -0.35 2.4e-11 Red cell distribution width; LUSC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg06028605 chr16:24865363 SLC5A11 0.68 10.29 0.49 9.04e-22 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs13256369 0.802 rs12153 chr8:8560909 G/C cg00074818 chr8:8560427 CLDN23 0.59 9.72 0.47 7.75e-20 Obesity-related traits; LUSC cis rs1018836 0.847 rs35409073 chr8:91648036 G/T cg16814680 chr8:91681699 NA -0.78 -12.79 -0.57 9.47e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg00504896 chr12:9437009 LOC642846 -0.4 -6.07 -0.32 3.49e-9 Breast size; LUSC cis rs9527 0.590 rs7910900 chr10:104829898 C/T cg05855489 chr10:104503620 C10orf26 0.53 7.97 0.4 2.6e-14 Arsenic metabolism; LUSC cis rs7937682 0.921 rs7130753 chr11:111470567 C/T cg22437258 chr11:111473054 SIK2 -0.45 -5.91 -0.31 8.45e-9 Primary sclerosing cholangitis; LUSC cis rs6500602 0.793 rs4785964 chr16:4484613 A/G cg08645402 chr16:4508243 NA 0.49 7.39 0.38 1.16e-12 Schizophrenia; LUSC cis rs8044868 0.530 rs2288000 chr16:72058881 A/G cg16579770 chr16:72058938 DHODH 0.34 5.73 0.3 2.26e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs9473147 0.571 rs9395285 chr6:47554177 G/A cg20196966 chr6:47445060 CD2AP 0.43 6.05 0.31 3.86e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg02951883 chr7:2050386 MAD1L1 -0.56 -10.46 -0.5 2.46e-22 Bipolar disorder and schizophrenia; LUSC cis rs11155671 0.530 rs7756850 chr6:150212596 G/C cg04369109 chr6:150039330 LATS1 -0.41 -5.71 -0.3 2.53e-8 Testicular germ cell tumor; LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg10729496 chr3:10149963 C3orf24 0.56 7.52 0.38 5.16e-13 Alzheimer's disease; LUSC cis rs61931739 0.534 rs4931783 chr12:34115322 G/A cg06521331 chr12:34319734 NA -0.48 -7.75 -0.39 1.11e-13 Morning vs. evening chronotype; LUSC cis rs3790645 1.000 rs444482 chr1:26890648 C/G cg17456097 chr1:26900765 RPS6KA1 0.42 6.07 0.32 3.44e-9 Glucose homeostasis traits; LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg01171360 chr6:293285 DUSP22 -0.53 -8.04 -0.4 1.57e-14 Menopause (age at onset); LUSC cis rs1577917 0.655 rs7742691 chr6:86278691 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 7.52 0.38 5.07e-13 Response to antipsychotic treatment; LUSC cis rs9325144 0.650 rs6582624 chr12:38733475 A/T cg26384229 chr12:38710491 ALG10B -0.58 -8.83 -0.44 5.99e-17 Morning vs. evening chronotype; LUSC cis rs7818345 0.845 rs7821446 chr8:19268822 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.32 -6.14 -0.32 2.38e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs9916302 0.706 rs9890198 chr17:37457480 A/C cg07936489 chr17:37558343 FBXL20 0.83 10.41 0.5 3.52e-22 Glomerular filtration rate (creatinine); LUSC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg20135002 chr11:47629003 NA 0.48 7.4 0.38 1.1e-12 Subjective well-being; LUSC cis rs3760982 0.967 rs12463346 chr19:44292244 A/G cg11993925 chr19:44307056 LYPD5 0.28 6.04 0.31 4.06e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs6867032 0.527 rs9312971 chr5:2012888 C/A cg26168224 chr5:2018326 NA 0.59 10.18 0.49 2.19e-21 Gut microbiome composition (winter); LUSC trans rs2302464 1.000 rs10516291 chr4:15732791 C/T cg17675199 chr6:35436792 RPL10A -0.83 -6.11 -0.32 2.84e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg13395646 chr4:1353034 KIAA1530 -0.59 -9.19 -0.45 4.18e-18 Obesity-related traits; LUSC cis rs5769707 0.605 rs2071900 chr22:50052175 A/G cg05373962 chr22:49881684 NA -0.4 -8.54 -0.42 4.72e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg12516959 chr21:47718080 NA -0.4 -6.59 -0.34 1.75e-10 Testicular germ cell tumor; LUSC cis rs9928842 0.679 rs4888361 chr16:75267676 A/G cg09066997 chr16:75300724 BCAR1 0.46 5.81 0.3 1.48e-8 Alcoholic chronic pancreatitis; LUSC cis rs476633 0.691 rs28568756 chr15:41539371 G/A cg18705301 chr15:41695430 NDUFAF1 -0.49 -8.72 -0.43 1.37e-16 Glomerular filtration rate (creatinine); LUSC cis rs4819052 0.679 rs2838859 chr21:46684517 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 11.56 0.53 3.04e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg26384229 chr12:38710491 ALG10B -0.82 -14.08 -0.61 1.14e-35 Bladder cancer; LUSC cis rs35146811 0.625 rs2906645 chr7:99817859 A/G cg22906224 chr7:99728672 NA -0.5 -6.94 -0.35 2.09e-11 Coronary artery disease; LUSC cis rs9393777 0.920 rs13207689 chr6:27369704 C/G cg09904177 chr6:26538194 HMGN4 -0.77 -5.72 -0.3 2.39e-8 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.71 0.3 2.48e-8 Menopause (age at onset); LUSC cis rs7223966 1.000 rs11654335 chr17:61797579 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.92 0.35 2.31e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10911251 0.528 rs10911263 chr1:183115018 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.64 0.5 5.92e-23 Colorectal cancer; LUSC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg17211192 chr8:82754475 SNX16 0.6 8.51 0.42 5.97e-16 Diastolic blood pressure; LUSC cis rs6867913 0.709 rs2338874 chr5:141466926 G/A cg08523384 chr5:141488047 NDFIP1 -0.41 -6.66 -0.34 1.11e-10 Asthma; LUSC cis rs28785552 0.769 rs11669363 chr19:53232321 C/A cg22067481 chr19:53234126 ZNF611 -0.51 -7.07 -0.36 9.02e-12 Response to paliperidone in schizophrenia (PANSS score); LUSC trans rs1997103 1.000 rs11238364 chr7:55407632 G/T cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC trans rs4650994 0.507 rs56229230 chr1:178526563 G/A cg05059571 chr16:84539110 KIAA1609 -0.48 -9.07 -0.44 1.07e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs7615952 0.515 rs7630575 chr3:125682330 A/G cg02807482 chr3:125708958 NA -0.46 -5.91 -0.31 8.58e-9 Blood pressure (smoking interaction); LUSC trans rs11148252 0.875 rs4884452 chr13:52949784 C/T cg18335740 chr13:41363409 SLC25A15 -0.53 -8.34 -0.42 1.91e-15 Lewy body disease; LUSC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg24209194 chr3:40518798 ZNF619 -0.43 -6.05 -0.31 3.8e-9 Renal cell carcinoma; LUSC cis rs1971762 0.522 rs10747680 chr12:54077776 T/G cg23533419 chr12:54090519 NA -0.37 -6.02 -0.31 4.7e-9 Height; LUSC cis rs4332037 0.538 rs4721164 chr7:1932629 C/G cg23422044 chr7:1970798 MAD1L1 -0.46 -5.82 -0.3 1.39e-8 Bipolar disorder; LUSC cis rs6840360 0.642 rs11726254 chr4:152438850 G/C cg20465933 chr4:152376761 FAM160A1 0.33 5.97 0.31 6.02e-9 Intelligence (multi-trait analysis); LUSC trans rs7937682 0.961 rs552387 chr11:111490047 T/G cg18187862 chr3:45730750 SACM1L 0.52 6.79 0.35 5.18e-11 Primary sclerosing cholangitis; LUSC cis rs7123876 0.587 rs61895588 chr11:72360986 A/G cg04827223 chr11:72435913 ARAP1 -0.59 -6.65 -0.34 1.22e-10 Body mass index; LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg06145435 chr7:1022769 CYP2W1 -0.33 -7.15 -0.36 5.44e-12 Longevity;Endometriosis; LUSC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg12560992 chr17:57184187 TRIM37 0.84 15.44 0.65 5.6e-41 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg06634786 chr22:41940651 POLR3H 0.52 6.07 0.32 3.47e-9 Vitiligo; LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.73 0.6 2.62e-34 Platelet count; LUSC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg26335602 chr6:28129616 ZNF389 0.42 5.68 0.3 2.87e-8 Depression; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04600299 chr7:149570367 ATP6V0E2;LOC401431 0.4 6.04 0.31 4.16e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg05776053 chr2:74358815 NA 0.43 6.41 0.33 5.02e-10 Gestational age at birth (maternal effect); LUSC cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg12219531 chr12:120966889 COQ5 0.61 8.14 0.41 8.02e-15 High light scatter reticulocyte count; LUSC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg18827107 chr12:86230957 RASSF9 -0.46 -6.88 -0.35 3.04e-11 Major depressive disorder; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg17372223 chr3:52568218 NT5DC2 0.39 6.37 0.33 6.23e-10 Electroencephalogram traits; LUSC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg25036284 chr2:26402008 FAM59B 0.69 9.36 0.46 1.17e-18 Gut microbiome composition (summer); LUSC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg06134567 chr22:46658398 PKDREJ -0.49 -5.84 -0.3 1.21e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs7824557 0.767 rs28507159 chr8:11166076 C/T cg15556689 chr8:8085844 FLJ10661 0.56 8.61 0.43 2.89e-16 Retinal vascular caliber; LUSC cis rs11105298 0.891 rs10777184 chr12:89919568 C/T cg00757033 chr12:89920650 WDR51B 0.59 10.22 0.49 1.69e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9910055 0.659 rs7207464 chr17:42245033 C/T cg13607699 chr17:42295918 UBTF 0.5 7.81 0.39 7.29e-14 Total body bone mineral density; LUSC cis rs9549367 0.737 rs11619691 chr13:113904636 T/C cg18105134 chr13:113819100 PROZ -0.68 -9.6 -0.47 1.9e-19 Platelet distribution width; LUSC cis rs9427116 0.875 rs11264233 chr1:154625632 C/T cg17218026 chr1:154582156 ADAR 0.5 8.59 0.43 3.34e-16 Blood protein levels; LUSC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg03929089 chr4:120376271 NA -0.76 -12.09 -0.55 3.64e-28 Height; LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 14.36 0.62 9.42e-37 Platelet count; LUSC trans rs4729127 1.000 rs17166205 chr7:94003841 T/A cg20086523 chr13:52378287 DHRS12 0.56 6.38 0.33 6.03e-10 Intelligence; LUSC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg23601095 chr6:26197514 HIST1H3D 0.68 7.36 0.37 1.48e-12 Gout;Renal underexcretion gout; LUSC cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg23711669 chr6:146136114 FBXO30 -0.82 -14.71 -0.63 3.97e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg13560548 chr3:10150139 C3orf24 0.48 6.6 0.34 1.6e-10 Alzheimer's disease; LUSC cis rs17270561 1.000 rs12211184 chr6:25823774 G/A cg16482183 chr6:26056742 HIST1H1C 0.8 10.21 0.49 1.77e-21 Iron status biomarkers; LUSC cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg03264133 chr6:25882463 NA -0.34 -5.69 -0.3 2.8e-8 Height; LUSC cis rs11122272 0.735 rs2790893 chr1:231508976 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.81 -0.47 3.85e-20 Hemoglobin concentration; LUSC cis rs2282802 0.685 rs2337138 chr5:139691664 A/C cg26211634 chr5:139558579 C5orf32 0.42 8.17 0.41 6.46e-15 Intelligence (multi-trait analysis); LUSC cis rs6429082 0.783 rs390539 chr1:235679690 A/C cg26050004 chr1:235667680 B3GALNT2 0.63 8.71 0.43 1.42e-16 Adiposity; LUSC cis rs477692 0.685 rs534430 chr10:131398734 A/C cg05714579 chr10:131428358 MGMT 0.5 7.11 0.36 6.88e-12 Response to temozolomide; LUSC cis rs9840812 0.769 rs534944 chr3:135961031 T/G cg15507776 chr3:136538369 TMEM22 0.43 5.93 0.31 7.5e-9 Fibrinogen levels; LUSC cis rs7945718 0.967 rs11826129 chr11:12768883 G/A cg25843174 chr11:12811716 TEAD1 0.31 6.92 0.35 2.3e-11 Educational attainment (years of education); LUSC cis rs308403 0.568 rs309358 chr4:123653926 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.8 10.65 0.5 5.19e-23 Blood protein levels; LUSC cis rs17255340 0.539 rs1144189 chr6:83982263 C/T cg08257003 chr6:84140564 ME1 0.32 7.59 0.38 3.17e-13 Platelet-derived growth factor BB levels; LUSC cis rs4702 0.611 rs2071382 chr15:91428197 T/C cg05469396 chr15:91419421 FURIN 0.49 8.68 0.43 1.74e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9467773 0.620 rs1490488 chr6:26614808 T/C cg11502198 chr6:26597334 ABT1 0.7 11.72 0.54 8.63e-27 Intelligence (multi-trait analysis); LUSC trans rs9929218 0.871 rs1862748 chr16:68832943 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -10.95 -0.51 4.85e-24 Colorectal cancer; LUSC trans rs561341 0.941 rs2428338 chr17:30299629 T/C cg27661571 chr11:113659931 NA -0.6 -7.21 -0.37 3.85e-12 Hip circumference adjusted for BMI; LUSC cis rs9287719 0.837 rs4331474 chr2:10755583 G/A cg00105475 chr2:10696890 NA 0.36 5.82 0.3 1.35e-8 Prostate cancer; LUSC cis rs887829 0.570 rs45615240 chr2:234599296 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.4 -6.33 -0.33 7.73e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs9662633 1.000 rs6695978 chr1:3648345 C/T cg06237983 chr7:27187269 HOXA6 -0.65 -5.97 -0.31 6.01e-9 Visceral adipose tissue adjusted for BMI; LUSC trans rs1147813 0.748 rs1023974 chr9:25864831 A/T cg23362473 chr20:4680742 PRNP 0.38 6.03 0.31 4.27e-9 Morning vs. evening chronotype; LUSC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg19077165 chr18:44547161 KATNAL2 -0.41 -6.25 -0.32 1.26e-9 Personality dimensions; LUSC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg06238570 chr21:40685208 BRWD1 -0.63 -10.76 -0.51 2.26e-23 Cognitive function; LUSC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 14.6 0.62 1.14e-37 Platelet count; LUSC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg03804128 chr16:635623 NA 0.32 6.42 0.33 4.63e-10 Height; LUSC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg04287289 chr16:89883240 FANCA 0.79 13.89 0.61 6.18e-35 Vitiligo; LUSC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg11366901 chr6:160182831 ACAT2 0.93 13.08 0.58 7.49e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg24562669 chr7:97807699 LMTK2 0.43 7.32 0.37 1.86e-12 Breast cancer; LUSC cis rs1729951 0.546 rs12054408 chr3:136677645 T/C cg21827317 chr3:136751795 NA 0.39 6.95 0.36 1.98e-11 Neuroticism; LUSC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg04756594 chr16:24857601 SLC5A11 -0.39 -5.96 -0.31 6.58e-9 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg12463550 chr7:65579703 CRCP -0.48 -7.09 -0.36 8.23e-12 Aortic root size; LUSC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg22920501 chr2:26401640 FAM59B -0.72 -10.25 -0.49 1.25e-21 Gut microbiome composition (summer); LUSC cis rs1775715 0.870 rs3847414 chr10:32219176 A/G cg18675610 chr10:32216311 ARHGAP12 0.27 5.91 0.31 8.27e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4780355 1.000 rs1111186 chr16:11347048 T/C cg00044050 chr16:11439710 C16orf75 0.5 7.28 0.37 2.35e-12 Crohn's disease and psoriasis; LUSC trans rs1994135 0.617 rs1384590 chr12:33734271 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.46 0.33 3.7e-10 Resting heart rate; LUSC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg09365446 chr1:150670422 GOLPH3L -0.42 -6.24 -0.32 1.3e-9 Tonsillectomy; LUSC cis rs829883 0.934 rs1641642 chr12:98898726 A/G cg25150519 chr12:98850993 NA 0.64 9.72 0.47 8.06e-20 Colorectal adenoma (advanced); LUSC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs500891 0.525 rs1170339 chr6:84031251 T/C cg08257003 chr6:84140564 ME1 0.34 8.05 0.4 1.43e-14 Platelet-derived growth factor BB levels; LUSC cis rs3087591 0.708 rs2189525 chr17:29668808 C/T cg24425628 chr17:29625626 OMG;NF1 -0.48 -7.4 -0.38 1.14e-12 Hip circumference; LUSC cis rs3733418 0.929 rs12510464 chr4:165919040 A/G cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -5.94 -0.31 7.19e-9 Obesity-related traits; LUSC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs6426558 0.515 rs7543579 chr1:227377699 A/T cg10327440 chr1:227177885 CDC42BPA -0.53 -7.22 -0.37 3.5e-12 Neutrophil percentage of white cells; LUSC cis rs1559088 0.947 rs12461219 chr19:33550633 C/G cg17764715 chr19:33622953 WDR88 0.58 7.88 0.4 4.53e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs67460515 0.500 rs9822435 chr3:160748068 A/T cg03342759 chr3:160939853 NMD3 -0.43 -5.65 -0.3 3.39e-8 Parkinson's disease; LUSC cis rs11048434 0.736 rs11048264 chr12:9113581 C/T cg13575925 chr12:9217583 LOC144571 -0.34 -6.62 -0.34 1.44e-10 Sjögren's syndrome; LUSC cis rs983392 0.679 rs1530914 chr11:60028940 C/T cg20284999 chr11:59952153 MS4A6A 0.37 6.27 0.32 1.09e-9 Alzheimer's disease (late onset); LUSC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.65 9.75 0.47 6.44e-20 Lymphocyte counts; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16249798 chr1:38325439 MTF1 -0.49 -7.43 -0.38 9.16e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg26162295 chr17:38119207 GSDMA -0.24 -5.81 -0.3 1.47e-8 Self-reported allergy; LUSC cis rs4919694 0.808 rs80020194 chr10:105035954 A/G cg04362960 chr10:104952993 NT5C2 1.17 12.3 0.56 6.27e-29 Arsenic metabolism; LUSC cis rs4478858 0.735 rs6676354 chr1:31800746 A/T cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC trans rs61931739 0.500 rs11053269 chr12:34545307 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg13628971 chr7:2884303 GNA12 0.45 6.45 0.33 3.9e-10 Height; LUSC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.85 -0.63 1.22e-38 Total body bone mineral density; LUSC cis rs77741769 0.571 rs11065324 chr12:121346795 C/G cg02419362 chr12:121203948 SPPL3 -0.44 -8.18 -0.41 6.19e-15 Mean corpuscular volume; LUSC cis rs10207628 0.698 rs13410629 chr2:127868733 C/T cg06223080 chr2:127868745 NA 0.38 6.56 0.34 2.06e-10 Psychosis and Alzheimer's disease; LUSC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.17 0.32 1.97e-9 Systolic blood pressure; LUSC cis rs2976388 1.000 rs2976388 chr8:143760256 G/A cg17252645 chr8:143867129 LY6D -0.38 -6.51 -0.34 2.8e-10 Urinary tract infection frequency; LUSC cis rs1865721 0.755 rs3213875 chr18:73184048 C/T cg26385618 chr18:73139727 C18orf62 -0.4 -7.22 -0.37 3.44e-12 Intelligence; LUSC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg12463550 chr7:65579703 CRCP -0.41 -5.91 -0.31 8.35e-9 Aortic root size; LUSC cis rs1801251 1.000 rs4973053 chr2:233670099 G/A cg25237894 chr2:233734115 C2orf82 -0.35 -6.34 -0.33 7.45e-10 Coronary artery disease; LUSC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg24829409 chr8:58192753 C8orf71 -0.45 -5.65 -0.3 3.37e-8 Developmental language disorder (linguistic errors); LUSC trans rs6841433 0.615 rs57059575 chr4:115472393 C/G cg01865118 chr8:29204221 DUSP4 -0.51 -5.97 -0.31 5.93e-9 Hemoglobin concentration; LUSC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg11247378 chr22:39784982 NA -0.62 -12.33 -0.56 4.86e-29 Intelligence (multi-trait analysis); LUSC cis rs7119 0.717 rs12902852 chr15:77809016 C/G cg27398640 chr15:77910606 LINGO1 -0.3 -6.38 -0.33 5.83e-10 Type 2 diabetes; LUSC trans rs7613875 0.600 rs1138536 chr3:50153356 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.53 8.34 0.42 1.94e-15 Body mass index; LUSC trans rs459571 0.959 rs392134 chr9:136909008 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.43 -6.13 -0.32 2.47e-9 Platelet distribution width; LUSC cis rs17255340 0.601 rs1144182 chr6:84023090 A/T cg08257003 chr6:84140564 ME1 0.33 7.85 0.39 5.81e-14 Platelet-derived growth factor BB levels; LUSC cis rs1538970 0.504 rs3790585 chr1:46023356 A/T cg05343316 chr1:45956843 TESK2 0.59 6.17 0.32 1.96e-9 Platelet count; LUSC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg08439880 chr3:133502540 NA -0.36 -6.41 -0.33 5.09e-10 Iron status biomarkers; LUSC cis rs12891047 0.804 rs35272075 chr14:68317999 G/T cg20999565 chr14:68265668 ZFYVE26 0.39 5.86 0.31 1.11e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9300255 0.602 rs1626899 chr12:123708063 A/G cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs17270561 0.609 rs4712959 chr6:25727057 C/T cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC cis rs1322512 1.000 rs2800631 chr6:153008631 T/C cg27316956 chr6:152958899 SYNE1 0.35 6.17 0.32 1.97e-9 Tonometry; LUSC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg22655196 chr4:3374909 RGS12 -0.32 -6.39 -0.33 5.44e-10 Serum sulfate level; LUSC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg22875332 chr1:76189707 ACADM -0.81 -11.16 -0.52 8.4e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs611744 0.806 rs2514846 chr8:109067105 C/G cg18478394 chr8:109455254 TTC35 0.42 6.19 0.32 1.81e-9 Dupuytren's disease; LUSC cis rs1395 0.744 rs11126936 chr2:27483101 A/C cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.5 -7.83 -0.39 6.35e-14 Blood metabolite levels; LUSC cis rs10089 1.000 rs3816006 chr5:127450581 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.77 0.54 5.38e-27 Ileal carcinoids; LUSC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg26335602 chr6:28129616 ZNF389 0.43 5.94 0.31 7.19e-9 Parkinson's disease; LUSC trans rs2243480 1.000 rs778704 chr7:65863467 T/C cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25396640 chr7:64255131 ZNF138 0.47 7.18 0.37 4.63e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs61931739 0.500 rs11053217 chr12:34470036 A/C cg06521331 chr12:34319734 NA -0.42 -6.88 -0.35 2.98e-11 Morning vs. evening chronotype; LUSC trans rs62103177 0.673 rs55852342 chr18:77594109 G/C cg05926928 chr17:57297772 GDPD1 1.05 13.34 0.59 7.73e-33 Opioid sensitivity; LUSC cis rs9815354 0.857 rs7652369 chr3:42020973 T/G cg03022575 chr3:42003672 ULK4 0.54 5.77 0.3 1.81e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg06001716 chr17:41278141 BRCA1;NBR2 -0.38 -6.16 -0.32 2.09e-9 Menopause (age at onset); LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg06640241 chr16:89574553 SPG7 0.7 11.42 0.53 9.98e-26 Multiple myeloma (IgH translocation); LUSC cis rs12310956 0.527 rs10772117 chr12:33900096 C/T cg06521331 chr12:34319734 NA -0.36 -5.86 -0.31 1.09e-8 Morning vs. evening chronotype; LUSC cis rs34779708 0.931 rs67976880 chr10:35372261 G/C cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg10645314 chr2:3704589 ALLC -0.49 -7.33 -0.37 1.72e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs11958404 0.615 rs10061079 chr5:157449968 G/C cg05962755 chr5:157440814 NA 0.39 5.71 0.3 2.53e-8 IgG glycosylation; LUSC cis rs7786877 0.626 rs11767547 chr7:100221635 C/T cg00334542 chr7:100209784 MOSPD3 -0.67 -7.51 -0.38 5.61e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs911555 0.755 rs8014013 chr14:103937372 A/G cg12935359 chr14:103987150 CKB 0.67 10.6 0.5 7.79e-23 Intelligence (multi-trait analysis); LUSC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg09839279 chr12:125627357 AACS 0.36 6.83 0.35 3.95e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg11494091 chr17:61959527 GH2 0.7 14.66 0.63 6.37e-38 Prudent dietary pattern; LUSC cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.52 7.27 0.37 2.56e-12 Gut microbiome composition (summer); LUSC cis rs9925964 0.967 rs9936329 chr16:31140799 G/T cg02466173 chr16:30829666 NA 0.33 6.06 0.31 3.7e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs73198271 0.653 rs3827811 chr8:8659038 C/T cg01851573 chr8:8652454 MFHAS1 0.47 7.86 0.39 5.52e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg21724239 chr8:58056113 NA 0.61 6.68 0.34 1.03e-10 Developmental language disorder (linguistic errors); LUSC cis rs11645898 0.935 rs11640722 chr16:72172300 C/T cg14768367 chr16:72042858 DHODH -0.65 -7.11 -0.36 7.28e-12 Blood protein levels; LUSC cis rs9467711 0.591 rs3734528 chr6:26022244 A/G cg16898833 chr6:26189333 HIST1H4D 0.65 6.1 0.32 3e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9560113 1.000 rs9555807 chr13:112179965 C/T cg14154082 chr13:112174009 NA 0.37 7.46 0.38 7.73e-13 Menarche (age at onset); LUSC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg11764359 chr7:65958608 NA 0.79 12.62 0.57 3.88e-30 Aortic root size; LUSC cis rs11190604 1.000 rs10883513 chr10:102316964 A/G cg07080220 chr10:102295463 HIF1AN 0.61 7.51 0.38 5.47e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg01879757 chr17:41196368 BRCA1 -0.46 -6.97 -0.36 1.72e-11 Menopause (age at onset); LUSC cis rs9902453 1.000 rs7222308 chr17:28277041 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.32 0.45 1.64e-18 Coffee consumption (cups per day); LUSC cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.51 0.38 5.46e-13 Colorectal cancer; LUSC cis rs3772130 1.000 rs11719458 chr3:121382005 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.65 9.65 0.47 1.37e-19 Cognitive performance; LUSC cis rs2274273 0.837 rs10141552 chr14:55746091 C/T cg04306507 chr14:55594613 LGALS3 -0.53 -11.79 -0.54 4.58e-27 Protein biomarker; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg13732083 chr21:47605072 C21orf56 -0.45 -6.7 -0.34 8.72e-11 Testicular germ cell tumor; LUSC cis rs981844 0.816 rs56413502 chr4:154721784 T/A cg14289246 chr4:154710475 SFRP2 0.48 6.08 0.32 3.27e-9 Response to statins (LDL cholesterol change); LUSC cis rs12956009 0.518 rs10164267 chr18:44820032 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.24 -0.37 3.09e-12 Educational attainment (years of education); LUSC cis rs11158026 0.603 rs56335168 chr14:55445132 C/A cg04306507 chr14:55594613 LGALS3 0.4 7.28 0.37 2.37e-12 Parkinson's disease; LUSC cis rs2413583 0.591 rs115038091 chr22:39728575 C/A cg17798944 chr22:39715225 SNORD43;RPL3 0.64 5.77 0.3 1.79e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs7394190 0.748 rs60212594 chr10:75414344 G/C cg07699608 chr10:75541558 CHCHD1 0.49 5.65 0.3 3.43e-8 Incident atrial fibrillation; LUSC trans rs6089829 0.962 rs3899032 chr20:61658542 G/A cg17470723 chr8:74884337 TCEB1 0.5 7.38 0.37 1.23e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg13175981 chr1:150552382 MCL1 0.43 6.15 0.32 2.25e-9 Tonsillectomy; LUSC cis rs9323205 0.634 rs56043194 chr14:51726066 A/C cg23942311 chr14:51606299 NA -0.39 -7.34 -0.37 1.69e-12 Cancer; LUSC trans rs7581030 0.501 rs2542524 chr2:71611829 A/G cg18809821 chr6:24403225 MRS2 -0.74 -6.5 -0.34 2.9e-10 Testicular germ cell tumor; LUSC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg05585544 chr11:47624801 NA -0.42 -7.26 -0.37 2.71e-12 Subjective well-being; LUSC cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.26 -0.37 2.66e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2439831 0.850 rs7169988 chr15:44060435 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.77 7.03 0.36 1.17e-11 Lung cancer in ever smokers; LUSC cis rs911555 0.546 rs28798508 chr14:104068970 T/C cg12935359 chr14:103987150 CKB -0.52 -7.94 -0.4 3.12e-14 Intelligence (multi-trait analysis); LUSC cis rs4795419 1 rs4795419 chr17:38166003 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.91 -0.35 2.47e-11 Monocyte percentage of white cells; LUSC cis rs9303280 0.901 rs9303277 chr17:37976469 C/T cg20243544 chr17:37824526 PNMT 0.39 5.89 0.31 9.61e-9 Self-reported allergy; LUSC cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.46 0.38 7.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg14820908 chr5:178986412 RUFY1 -0.64 -12.12 -0.55 2.97e-28 Lung cancer; LUSC cis rs4776059 1.000 rs12902679 chr15:52881317 C/T cg25063058 chr15:52860530 ARPP19 -0.47 -6.24 -0.32 1.33e-9 Schizophrenia; LUSC cis rs7647973 0.667 rs6446286 chr3:49681704 A/G cg03060546 chr3:49711283 APEH 0.67 7.7 0.39 1.51e-13 Menarche (age at onset); LUSC cis rs362272 0.525 rs910568 chr4:3307373 A/G cg14583973 chr4:3374767 RGS12 0.33 6.92 0.35 2.38e-11 Serum sulfate level; LUSC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg17971929 chr21:40555470 PSMG1 -0.67 -10.94 -0.51 5.28e-24 Cognitive function; LUSC trans rs6502050 0.799 rs12940433 chr17:80120826 C/T cg07393940 chr7:158741817 NA 0.36 6.47 0.33 3.58e-10 Life satisfaction; LUSC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg27432699 chr2:27873401 GPN1 0.56 8.32 0.41 2.3e-15 Total body bone mineral density; LUSC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg02463440 chr8:22132932 PIWIL2 0.44 7.96 0.4 2.74e-14 Hypertriglyceridemia; LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg13902645 chr11:5959945 NA -0.63 -9.03 -0.44 1.43e-17 DNA methylation (variation); LUSC cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9788682 0.747 rs2656069 chr15:78745707 C/T cg06917634 chr15:78832804 PSMA4 0.48 6.02 0.31 4.61e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg04362960 chr10:104952993 NT5C2 0.55 8.78 0.43 8.92e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg19622623 chr12:86230825 RASSF9 0.41 5.93 0.31 7.38e-9 Major depressive disorder; LUSC cis rs733592 0.560 rs2158515 chr12:48507668 T/C cg24011408 chr12:48396354 COL2A1 -0.53 -8.78 -0.43 8.53e-17 Plateletcrit; LUSC cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg06484146 chr7:12443880 VWDE -0.62 -6.23 -0.32 1.37e-9 Coronary artery disease; LUSC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.54e-11 Extrinsic epigenetic age acceleration; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11890956 chr21:40555474 PSMG1 -0.91 -15.95 -0.66 5.82e-43 Cognitive function; LUSC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg19748678 chr4:122722346 EXOSC9 -0.49 -7.67 -0.39 1.93e-13 Type 2 diabetes; LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03352830 chr11:487213 PTDSS2 -0.7 -8.86 -0.44 4.74e-17 Body mass index; LUSC cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg06784218 chr1:46089804 CCDC17 0.48 9.63 0.47 1.62e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4343996 0.543 rs10224159 chr7:3420488 C/T cg21248987 chr7:3385318 SDK1 0.36 6.07 0.32 3.52e-9 Motion sickness; LUSC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg27189623 chr16:705930 WDR90 0.35 5.65 0.3 3.51e-8 Height; LUSC cis rs9921222 0.500 rs11648673 chr16:377794 G/A cg26944245 chr16:421049 TMEM8A;MRPL28 0.43 6.48 0.33 3.35e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg15691649 chr6:25882328 NA -0.41 -6.02 -0.31 4.57e-9 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg05347473 chr6:146136440 FBXO30 0.53 9.04 0.44 1.3e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs7107174 1.000 rs2510046 chr11:77988817 T/C cg02023728 chr11:77925099 USP35 0.48 6.81 0.35 4.44e-11 Testicular germ cell tumor; LUSC cis rs7937682 0.632 rs11823089 chr11:111673539 A/G cg09085632 chr11:111637200 PPP2R1B 0.94 12.83 0.57 6.32e-31 Primary sclerosing cholangitis; LUSC cis rs73198271 0.595 rs11780672 chr8:8584153 A/C cg01851573 chr8:8652454 MFHAS1 0.5 6.04 0.31 4.03e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11792861 0.926 rs59904140 chr9:111910051 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.6 8.99 0.44 1.9e-17 Menarche (age at onset); LUSC cis rs701145 0.938 rs813141 chr3:154066521 T/C cg17054900 chr3:154042577 DHX36 0.79 8.25 0.41 3.74e-15 Coronary artery disease; LUSC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg03351412 chr1:154909251 PMVK 0.53 8.39 0.42 1.42e-15 Prostate cancer; LUSC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg10755058 chr3:40428713 ENTPD3 0.35 5.79 0.3 1.58e-8 Renal cell carcinoma; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg26384229 chr12:38710491 ALG10B 0.88 14.7 0.63 4.61e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg21681030 chr2:46777652 RHOQ 0.47 6.44 0.33 4.12e-10 Height; LUSC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg09165964 chr15:75287851 SCAMP5 -1.16 -19.53 -0.73 3.42e-57 Blood trace element (Zn levels); LUSC cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg00071950 chr4:10020882 SLC2A9 -0.57 -9.21 -0.45 3.78e-18 Bone mineral density; LUSC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg02609749 chr16:89786786 C16orf7;ZNF276 0.49 8.37 0.42 1.55e-15 Vitiligo; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07856758 chr19:37861652 ZNF527 0.34 6.36 0.33 6.61e-10 Triglycerides; LUSC cis rs8062405 1.000 rs4788095 chr16:28831359 T/C cg09754948 chr16:28834200 ATXN2L 0.44 6.43 0.33 4.51e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7267979 1.000 rs2482919 chr20:25299756 T/C cg03522245 chr20:25566470 NINL -0.36 -5.81 -0.3 1.43e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1775715 0.870 rs1251407 chr10:32238325 A/G cg26784012 chr10:32216390 ARHGAP12 0.41 6.72 0.34 8e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs60843830 0.661 rs7561648 chr2:105171 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.45 6.66 0.34 1.16e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg22875332 chr1:76189707 ACADM 0.8 12.63 0.57 3.72e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs57920188 0.584 rs10915654 chr1:4091419 C/A cg20703997 chr1:4087676 NA 0.57 8.34 0.42 1.96e-15 Interleukin-17 levels; LUSC cis rs17685 0.664 rs9801113 chr7:75792031 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg20203395 chr5:56204925 C5orf35 -0.76 -10.43 -0.5 3.03e-22 Initial pursuit acceleration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11427898 chr15:38544983 SPRED1 -0.5 -6.72 -0.35 7.63e-11 Bipolar disorder and schizophrenia; LUSC cis rs314370 0.951 rs17881696 chr7:100493359 G/A cg18683606 chr7:100471612 SRRT 0.46 6.12 0.32 2.56e-9 Resting heart rate; LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg11062466 chr8:58055876 NA 0.66 8.67 0.43 1.93e-16 Developmental language disorder (linguistic errors); LUSC cis rs7523050 0.908 rs12405585 chr1:109397229 C/A cg08274380 chr1:109419600 GPSM2 0.88 9.59 0.46 2.07e-19 Fat distribution (HIV); LUSC cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg05347473 chr6:146136440 FBXO30 0.54 9.31 0.45 1.71e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg11663144 chr21:46675770 NA -0.4 -6.98 -0.36 1.56e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11229555 0.645 rs10896778 chr11:58193925 T/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.74 -12.81 -0.57 8.14e-31 Total body bone mineral density; LUSC cis rs10088262 0.591 rs13270541 chr8:124794849 G/A cg02993010 chr8:124780839 FAM91A1 -0.47 -5.65 -0.3 3.38e-8 Pancreatic cancer; LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC trans rs561341 1.000 rs8064843 chr17:30245744 A/G cg20587970 chr11:113659929 NA -1.07 -14.2 -0.61 4.08e-36 Hip circumference adjusted for BMI; LUSC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.49 0.42 7.07e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2288327 0.643 rs1559908 chr2:179336347 C/T cg18634211 chr1:26737262 LIN28 -0.54 -7.03 -0.36 1.15e-11 Atrial fibrillation; LUSC cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg27279351 chr12:120934652 DYNLL1 0.62 8.23 0.41 4.34e-15 High light scatter reticulocyte count; LUSC trans rs8072100 0.875 rs9635762 chr17:45648446 A/C cg03886242 chr7:26192032 NFE2L3 0.37 6.26 0.32 1.18e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs908922 0.676 rs1053590 chr1:152488428 T/C cg20991723 chr1:152506922 NA 0.5 9.41 0.46 8.31e-19 Hair morphology; LUSC cis rs829880 0.570 rs844205 chr12:98846053 A/G cg25150519 chr12:98850993 NA 0.73 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -8.34 -0.42 1.92e-15 Triglycerides; LUSC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg11663144 chr21:46675770 NA -0.42 -7.27 -0.37 2.57e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs8022179 0.580 rs58153827 chr14:103844630 G/A cg17675199 chr6:35436792 RPL10A -0.49 -6.1 -0.32 2.88e-9 Monocyte count; LUSC cis rs11229555 0.645 rs10896775 chr11:58175989 A/T cg15696309 chr11:58395628 NA -0.63 -7.81 -0.39 7.37e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs12753569 1.000 rs12753569 chr1:76484014 G/T cg00791851 chr1:76518896 NA -0.32 -6.09 -0.32 3.09e-9 Personality dimensions; LUSC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg00800038 chr16:89945340 TCF25 0.62 6.4 0.33 5.35e-10 Skin colour saturation; LUSC cis rs6967385 0.934 rs17165850 chr7:12366064 G/C cg20607287 chr7:12443886 VWDE 0.4 5.84 0.3 1.25e-8 Response to taxane treatment (placlitaxel); LUSC trans rs3749237 0.964 rs35210174 chr3:49812606 C/T cg21659725 chr3:3221576 CRBN 0.62 8.69 0.43 1.61e-16 Resting heart rate; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.72 0.78 9.87e-70 Prudent dietary pattern; LUSC cis rs4964805 0.594 rs4981036 chr12:104164344 C/G cg02344784 chr12:104178138 NT5DC3 0.38 6.05 0.31 3.94e-9 Attention deficit hyperactivity disorder; LUSC cis rs6121246 0.954 rs6089093 chr20:30421459 C/T cg18721089 chr20:30220636 NA -0.34 -5.68 -0.3 2.95e-8 Mean corpuscular hemoglobin; LUSC trans rs3733585 0.673 rs4580649 chr4:9948461 G/A cg26043149 chr18:55253948 FECH -0.45 -6.85 -0.35 3.48e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9287719 0.967 rs715247 chr2:10736291 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg07703079 chr11:430292 ANO9 0.6 6.59 0.34 1.75e-10 Body mass index; LUSC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.09 15.86 0.66 1.25e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg17252645 chr8:143867129 LY6D 0.36 6.29 0.33 1.02e-9 Urinary tract infection frequency; LUSC cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg01028140 chr2:1542097 TPO 0.61 8.1 0.41 1.05e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs3768617 0.510 rs10752904 chr1:183101038 A/G ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg07212818 chr11:638076 DRD4 -0.49 -7.99 -0.4 2.21e-14 Systemic lupus erythematosus; LUSC cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg05347473 chr6:146136440 FBXO30 0.53 9.06 0.44 1.13e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs1577917 0.917 rs2084293 chr6:86566002 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs6901250 1.000 rs615199 chr6:117113653 T/C cg12892004 chr6:117198278 RFX6 0.44 8.04 0.4 1.58e-14 C-reactive protein levels; LUSC cis rs10779751 0.770 rs2015818 chr1:11170743 G/A cg04508216 chr1:11107452 MASP2 0.31 5.7 0.3 2.58e-8 Body mass index; LUSC cis rs7216064 1.000 rs4318247 chr17:65882172 A/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs12579753 0.917 rs7313521 chr12:82205656 G/A cg07923666 chr12:49932857 KCNH3 -0.49 -6.14 -0.32 2.29e-9 Resting heart rate; LUSC cis rs5758659 0.657 rs5758587 chr22:42517636 C/G cg15557168 chr22:42548783 NA 0.35 5.86 0.31 1.11e-8 Cognitive function; LUSC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1950626 0.750 rs35820579 chr14:101435515 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.73 0.39 1.25e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs9303401 0.659 rs16943326 chr17:57050365 C/T cg25039879 chr17:56429692 SUPT4H1 0.7 9.24 0.45 3.06e-18 Cognitive test performance; LUSC cis rs7584330 0.780 rs937395 chr2:238378749 T/C cg16989719 chr2:238392110 NA -0.4 -6.89 -0.35 2.84e-11 Prostate cancer; LUSC cis rs28647808 0.786 rs28590601 chr9:136256224 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs459571 0.959 rs455381 chr9:136905577 C/A cg13789015 chr9:136890014 NCRNA00094 0.73 13.36 0.59 6.58e-33 Platelet distribution width; LUSC cis rs6430585 0.528 rs660002 chr2:136723504 C/T cg07169764 chr2:136633963 MCM6 1.03 16.47 0.67 4.8e-45 Corneal structure; LUSC cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC trans rs60843830 1.000 rs114976176 chr2:264621 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.17 0.49 2.49e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg09796270 chr17:17721594 SREBF1 0.43 7.45 0.38 8.14e-13 Total body bone mineral density; LUSC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08704250 chr15:31115839 NA 0.4 6.02 0.31 4.47e-9 Huntington's disease progression; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg08088566 chr11:430123 ANO9 0.61 7.11 0.36 7.06e-12 Body mass index; LUSC cis rs1682361 1 rs1682361 chr3:136734014 G/C cg21827317 chr3:136751795 NA 0.52 9.52 0.46 3.62e-19 Schizophrenia; LUSC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg18402987 chr7:1209562 NA 0.68 7.18 0.37 4.63e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10740039 0.883 rs2393676 chr10:62390258 A/G cg18175470 chr10:62150864 ANK3 -0.47 -7.22 -0.37 3.57e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg25067162 chr17:41277974 BRCA1;NBR2 0.33 5.73 0.3 2.23e-8 Menopause (age at onset); LUSC cis rs561341 0.700 rs6505266 chr17:30225813 G/A cg13647721 chr17:30228624 UTP6 0.68 9.06 0.44 1.09e-17 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg17366294 chr4:99064904 C4orf37 0.58 9.89 0.48 2.08e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs977987 0.843 rs4888415 chr16:75448921 C/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.73 -0.35 7.62e-11 Dupuytren's disease; LUSC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg02415014 chr8:143852576 LYNX1 0.26 5.88 0.31 9.95e-9 Urinary tract infection frequency; LUSC cis rs950173 1.000 rs13000153 chr2:172586067 A/G cg13550731 chr2:172543902 DYNC1I2 -0.78 -7.59 -0.38 3.32e-13 Hippocampal volume; LUSC cis rs16867321 0.950 rs12472841 chr2:181491840 C/A cg23363182 chr2:181467187 NA -0.44 -5.95 -0.31 6.72e-9 Obesity; LUSC cis rs9527 0.615 rs17725614 chr10:104685493 G/C cg05855489 chr10:104503620 C10orf26 0.52 8.02 0.4 1.85e-14 Arsenic metabolism; LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg24813613 chr7:1882135 MAD1L1 -0.43 -7.24 -0.37 3.11e-12 Bipolar disorder and schizophrenia; LUSC cis rs7582180 0.764 rs11691684 chr2:100921776 T/A cg12002119 chr2:101014098 CHST10 0.35 5.85 0.3 1.18e-8 Intelligence (multi-trait analysis); LUSC cis rs10876993 0.890 rs812304 chr12:58074853 A/C cg15848620 chr12:58087721 OS9 -0.56 -8.04 -0.4 1.62e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg13319975 chr6:146136371 FBXO30 0.5 7.44 0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs8141529 0.732 rs5997408 chr22:29207915 G/A cg02153584 chr22:29168773 CCDC117 0.66 10.36 0.49 5.47e-22 Lymphocyte counts; LUSC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.6e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs56176327 0.583 rs7613603 chr3:49812866 C/T cg03060546 chr3:49711283 APEH -0.62 -7.37 -0.37 1.37e-12 Intelligence (multi-trait analysis); LUSC cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg16586182 chr3:47516702 SCAP 0.5 7.73 0.39 1.32e-13 Colorectal cancer; LUSC cis rs9287719 0.934 rs6432111 chr2:10744620 A/C cg00105475 chr2:10696890 NA 0.38 6.29 0.33 1e-9 Prostate cancer; LUSC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg20406979 chr6:167373233 NA 0.26 5.91 0.31 8.5e-9 Crohn's disease; LUSC cis rs11758351 1.000 rs41266807 chr6:26199822 A/G cg23601095 chr6:26197514 HIST1H3D 0.72 7.41 0.38 1.04e-12 Gout;Renal underexcretion gout; LUSC cis rs11051970 0.545 rs2651374 chr12:32582858 G/A cg02745156 chr12:32552066 NA 0.36 6.51 0.34 2.71e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg23985595 chr17:80112537 CCDC57 -0.31 -6.13 -0.32 2.41e-9 Life satisfaction; LUSC cis rs1440410 0.835 rs11940580 chr4:144161525 C/G cg01719995 chr4:144104893 USP38 0.34 5.88 0.31 1e-8 Ischemic stroke; LUSC cis rs2204008 0.654 rs1290325 chr12:38152910 C/T cg13010199 chr12:38710504 ALG10B -0.54 -8.24 -0.41 4.01e-15 Bladder cancer; LUSC cis rs2806561 0.765 rs1612905 chr1:23510023 G/T cg12483005 chr1:23474871 LUZP1 0.43 6.72 0.35 7.64e-11 Height; LUSC cis rs1506636 1.000 rs614645 chr7:123442349 T/C cg03229431 chr7:123269106 ASB15 0.63 10.16 0.49 2.59e-21 Plateletcrit;Platelet count; LUSC cis rs11190604 1.000 rs7078799 chr10:102301447 G/A cg07080220 chr10:102295463 HIF1AN 0.69 9.22 0.45 3.53e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg26338869 chr17:61819248 STRADA 0.42 6.1 0.32 2.96e-9 Prudent dietary pattern; LUSC cis rs2204008 0.715 rs3899385 chr12:38169880 C/G cg13010199 chr12:38710504 ALG10B 0.68 10.62 0.5 6.57e-23 Bladder cancer; LUSC cis rs1008375 0.931 rs4479701 chr4:17571496 G/A cg16339924 chr4:17578868 LAP3 0.61 9.29 0.45 2.07e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3857536 0.813 rs6931701 chr6:66940905 T/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.45 -0.42 9.43e-16 Lung cancer; LUSC cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg07274523 chr3:49395745 GPX1 0.65 10.3 0.49 8.85e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs1577917 0.740 rs12212560 chr6:86342679 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -9.59 -0.46 2.2e-19 Response to antipsychotic treatment; LUSC cis rs9814567 0.806 rs9857242 chr3:134316378 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.74 11.58 0.54 2.7e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg22535103 chr8:58192502 C8orf71 -0.78 -8.31 -0.41 2.51e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.876 rs11752223 chr6:86573394 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -9.05 -0.44 1.18e-17 Response to antipsychotic treatment; LUSC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.01e-11 Tonsillectomy; LUSC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg21153622 chr11:89784906 NA -0.4 -6.19 -0.32 1.73e-9 HDL cholesterol; LUSC cis rs1577917 1.000 rs2816815 chr6:86691656 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.19 -0.32 1.76e-9 Response to antipsychotic treatment; LUSC cis rs9790314 0.875 rs336568 chr3:161072763 G/C cg03342759 chr3:160939853 NMD3 -0.51 -8.42 -0.42 1.09e-15 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14155567 chr7:5540534 FBXL18 0.47 6.2 0.32 1.7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs61931739 0.500 rs73103774 chr12:34482279 C/T cg06521331 chr12:34319734 NA -0.41 -6.33 -0.33 7.7e-10 Morning vs. evening chronotype; LUSC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg16743903 chr16:89593216 SPG7 -0.36 -5.66 -0.3 3.23e-8 Multiple myeloma (IgH translocation); LUSC trans rs61931739 0.500 rs3934517 chr12:34451396 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.32e-18 Morning vs. evening chronotype; LUSC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.17 0.52 8.2e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4319547 0.737 rs10846920 chr12:122943231 C/T cg05707623 chr12:122985044 ZCCHC8 -0.59 -7.57 -0.38 3.65e-13 Body mass index; LUSC cis rs9549260 0.755 rs4943798 chr13:41202948 T/C cg21288729 chr13:41239152 FOXO1 0.61 9.56 0.46 2.74e-19 Red blood cell count; LUSC cis rs9287719 0.745 rs4997809 chr2:10755542 G/A cg03983476 chr2:10830698 NOL10 -0.38 -5.77 -0.3 1.83e-8 Prostate cancer; LUSC cis rs12579753 0.879 rs11615729 chr12:82128318 T/A cg07988820 chr12:82153109 PPFIA2 -0.45 -6.4 -0.33 5.35e-10 Resting heart rate; LUSC trans rs7615952 0.736 rs11921945 chr3:125643719 A/G cg07211511 chr3:129823064 LOC729375 -1.23 -21.05 -0.76 3.19e-63 Blood pressure (smoking interaction); LUSC cis rs7615316 0.779 rs6440077 chr3:142017527 A/G cg16271453 chr3:142027066 XRN1 -0.41 -7.08 -0.36 8.42e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.41 -6.3 -0.33 9.42e-10 Intelligence (multi-trait analysis); LUSC cis rs2742417 0.624 rs2742394 chr3:45757591 C/T cg04837898 chr3:45731254 SACM1L -0.43 -6.96 -0.36 1.79e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9487051 0.768 rs9480910 chr6:109521707 T/C cg00509249 chr6:109615579 CCDC162 -0.33 -5.79 -0.3 1.66e-8 Reticulocyte fraction of red cells; LUSC cis rs4343996 0.902 rs7798672 chr7:3342334 A/T cg21248987 chr7:3385318 SDK1 0.41 6.96 0.36 1.78e-11 Motion sickness; LUSC cis rs7432375 0.610 rs7633629 chr3:136517028 T/A cg15507776 chr3:136538369 TMEM22 0.44 7.34 0.37 1.68e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg14893161 chr1:205819251 PM20D1 0.43 5.89 0.31 9.19e-9 Parkinson's disease; LUSC cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.82 11.9 0.55 1.85e-27 Chronic sinus infection; LUSC trans rs7829975 0.807 rs519019 chr8:8595104 A/T cg21775007 chr8:11205619 TDH -0.43 -6.08 -0.32 3.31e-9 Mood instability; LUSC cis rs11158026 0.603 rs59323730 chr14:55439075 C/T cg04306507 chr14:55594613 LGALS3 0.4 7.43 0.38 9.29e-13 Parkinson's disease; LUSC cis rs9300255 0.722 rs12304248 chr12:123810425 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.37 5.65 0.3 3.41e-8 Neutrophil percentage of white cells; LUSC cis rs1413885 0.549 rs9436725 chr1:65852870 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.46 6.76 0.35 6.34e-11 Anticoagulant levels; LUSC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg06808227 chr14:105710500 BRF1 -0.67 -10.53 -0.5 1.37e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.23 0.56 1.11e-28 Motion sickness; LUSC cis rs1499972 0.941 rs62264762 chr3:117634443 C/A cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.95e-8 Schizophrenia; LUSC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg08125733 chr17:73851984 WBP2 -0.5 -7.1 -0.36 7.43e-12 White matter hyperintensity burden; LUSC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03264133 chr6:25882463 NA 0.45 7.47 0.38 6.86e-13 Intelligence (multi-trait analysis); LUSC cis rs6469656 0.892 rs10093551 chr8:117712821 T/C cg24004040 chr8:117650383 NA -0.42 -6.26 -0.32 1.16e-9 Colorectal cancer; LUSC cis rs929354 0.566 rs6979947 chr7:157005863 C/T cg17757837 chr7:157058334 UBE3C -0.75 -10.52 -0.5 1.48e-22 Body mass index; LUSC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.84 -0.35 3.69e-11 Crohn's disease; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg22638593 chr5:131593259 PDLIM4 0.5 7.49 0.38 6.15e-13 Acylcarnitine levels; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.58 -9.09 -0.45 9.29e-18 Lymphocyte counts; LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg23758822 chr17:41437982 NA 1.04 19.44 0.73 7.67e-57 Menopause (age at onset); LUSC cis rs11676348 0.755 rs62183956 chr2:219046122 C/T cg00012203 chr2:219082015 ARPC2 0.62 10.52 0.5 1.49e-22 Ulcerative colitis; LUSC trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg25482853 chr8:67687455 SGK3 1.18 16.98 0.68 4.85e-47 Lung disease severity in cystic fibrosis; LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg27170947 chr2:26402098 FAM59B -0.63 -8.91 -0.44 3.31e-17 Gut microbiome composition (summer); LUSC cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg17845761 chr1:175162550 KIAA0040 0.33 6.29 0.33 1.02e-9 Alcohol dependence; LUSC cis rs6545883 0.894 rs12615783 chr2:61440947 T/C cg15711740 chr2:61764176 XPO1 0.45 6.7 0.34 8.64e-11 Tuberculosis; LUSC cis rs10089 0.904 rs3087889 chr5:127524944 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.78 0.54 5.19e-27 Ileal carcinoids; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg21782813 chr7:2030301 MAD1L1 0.37 6.03 0.31 4.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg07959070 chr22:50026188 C22orf34 -0.34 -7.08 -0.36 8.32e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9653442 0.675 rs7605430 chr2:100647552 C/G cg07810366 chr2:100720526 AFF3 0.41 7.1 0.36 7.68e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04791162 chr14:62331287 NA 0.5 5.97 0.31 6.16e-9 Bipolar disorder and schizophrenia; LUSC cis rs826838 0.809 rs11169666 chr12:39211300 T/C cg26384229 chr12:38710491 ALG10B 0.89 16.68 0.67 7.5e-46 Heart rate; LUSC cis rs1395 0.778 rs62128747 chr2:27412605 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.2 0.37 4.12e-12 Blood metabolite levels; LUSC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -5.96 -0.31 6.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.602 rs1727313 chr12:123640853 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -5.77 -0.3 1.77e-8 Neutrophil percentage of white cells; LUSC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg09034736 chr1:150693464 HORMAD1 -0.44 -6.05 -0.31 3.79e-9 Blood protein levels; LUSC cis rs9296092 0.517 rs56043172 chr6:33522363 T/G cg13560919 chr6:33536144 NA -0.82 -15.86 -0.66 1.26e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7428 0.527 rs7608892 chr2:85542718 G/A cg24342717 chr2:85555507 TGOLN2 -0.74 -12.32 -0.56 5.35e-29 Ear protrusion; LUSC cis rs59104589 0.617 rs60132543 chr2:242344599 T/C cg14842376 chr2:242211374 HDLBP 0.54 6.33 0.33 7.68e-10 Fibrinogen levels; LUSC cis rs6815814 0.851 rs73235002 chr4:38769018 A/G cg02016764 chr4:38805732 TLR1 -0.53 -5.79 -0.3 1.65e-8 Breast cancer; LUSC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.53 -7.81 -0.39 7.49e-14 Platelet count; LUSC cis rs929596 0.785 rs6714634 chr2:234664765 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.69 11.69 0.54 1.1e-26 Total bilirubin levels in HIV-1 infection; LUSC cis rs62400317 0.859 rs10456121 chr6:45092545 G/A cg20913747 chr6:44695427 NA -0.46 -7.41 -0.38 1.06e-12 Total body bone mineral density; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09700085 chr3:45838028 SLC6A20 0.46 7.33 0.37 1.71e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs7659604 0.540 rs28615388 chr4:122678418 C/T cg19748678 chr4:122722346 EXOSC9 -0.4 -5.87 -0.31 1.06e-8 Type 2 diabetes; LUSC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.07 -0.32 3.51e-9 Alzheimer's disease (late onset); LUSC cis rs72634258 0.740 rs4489581 chr1:8174495 A/C cg00042356 chr1:8021962 PARK7 -0.58 -7.11 -0.36 7.2e-12 Inflammatory bowel disease; LUSC cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg16384552 chr7:74938386 SPDYE8P 0.48 7.02 0.36 1.22e-11 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9549260 0.591 rs9577108 chr13:41271764 G/A cg21288729 chr13:41239152 FOXO1 0.54 8.28 0.41 3.09e-15 Red blood cell count; LUSC cis rs1775715 0.707 rs2778669 chr10:32161541 C/T cg26784012 chr10:32216390 ARHGAP12 0.45 7.77 0.39 9.75e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7771547 0.573 rs544267 chr6:36398302 A/G cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC cis rs9549260 0.755 rs7328677 chr13:41229905 A/G cg21288729 chr13:41239152 FOXO1 0.64 9.88 0.48 2.31e-20 Red blood cell count; LUSC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg22823121 chr1:150693482 HORMAD1 -0.52 -7.69 -0.39 1.63e-13 Melanoma; LUSC trans rs7100689 0.646 rs10788562 chr10:82072310 C/T cg07663200 chr17:42030104 NA 0.36 6.01 0.31 4.74e-9 Post bronchodilator FEV1; LUSC cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 7.4 0.38 1.11e-12 Colorectal cancer; LUSC trans rs853679 0.607 rs67040724 chr6:27905509 T/C cg01620082 chr3:125678407 NA -0.83 -7.31 -0.37 1.98e-12 Depression; LUSC cis rs644148 0.704 rs2686761 chr19:44989752 T/C cg15540054 chr19:45004280 ZNF180 -0.52 -7.19 -0.37 4.19e-12 Personality dimensions; LUSC cis rs7937682 0.961 rs7119563 chr11:111543916 T/A cg19812747 chr11:111475976 SIK2 0.5 6.88 0.35 2.96e-11 Primary sclerosing cholangitis; LUSC cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg23711669 chr6:146136114 FBXO30 0.88 15.92 0.66 7.5e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7818345 0.904 rs11780388 chr8:19271554 A/G cg11303988 chr8:19266685 CSGALNACT1 0.37 7.02 0.36 1.24e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg21535247 chr6:8435926 SLC35B3 0.59 9.06 0.44 1.09e-17 Motion sickness; LUSC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg24550644 chr17:30846204 MYO1D -0.52 -9.11 -0.45 7.93e-18 Schizophrenia; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg03352830 chr11:487213 PTDSS2 0.69 8.57 0.42 3.78e-16 Body mass index; LUSC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg14583973 chr4:3374767 RGS12 0.39 8.5 0.42 6.21e-16 Serum sulfate level; LUSC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg12463550 chr7:65579703 CRCP -0.46 -6.82 -0.35 4.21e-11 Aortic root size; LUSC cis rs2377585 0.653 rs7299203 chr12:8849161 G/A cg03761649 chr12:8850719 RIMKLB 0.46 6.47 0.33 3.52e-10 Reticulocyte fraction of red cells; LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.99 -0.31 5.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs61863818 0.709 rs10786343 chr10:99159465 C/A cg06359132 chr10:99160096 RRP12 -0.25 -5.74 -0.3 2.14e-8 Monocyte percentage of white cells; LUSC cis rs9303401 0.659 rs35103007 chr17:56900738 G/A cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.09e-17 Cognitive test performance; LUSC cis rs4804416 1.000 rs4804414 chr19:7223785 C/T cg09779027 chr19:7224513 INSR 0.29 5.92 0.31 8.15e-9 Thyroid hormone levels;Hypothyroidism; LUSC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg07389463 chr12:132296394 NA 0.39 6.89 0.35 2.81e-11 Migraine; LUSC cis rs752010 0.523 rs10890158 chr1:42117985 C/T cg06885757 chr1:42089581 HIVEP3 0.5 10.17 0.49 2.36e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7937890 0.874 rs6486191 chr11:14403739 G/A cg19336497 chr11:14380999 RRAS2 -0.33 -6.04 -0.31 4.15e-9 Mitochondrial DNA levels; LUSC trans rs61931739 0.500 rs11053193 chr12:34438838 G/T cg26384229 chr12:38710491 ALG10B 0.9 15.63 0.65 9.84e-42 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg16606324 chr3:10149918 C3orf24 -0.64 -9.68 -0.47 1.05e-19 Alzheimer's disease; LUSC cis rs1577917 0.917 rs2218594 chr6:86543766 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -9.04 -0.44 1.28e-17 Response to antipsychotic treatment; LUSC cis rs5753037 0.838 rs140147 chr22:30184599 C/T cg11564601 chr22:30592435 NA 0.34 5.7 0.3 2.62e-8 Type 1 diabetes; LUSC cis rs11608355 0.672 rs9943689 chr12:109890339 G/A cg05360138 chr12:110035743 NA 0.58 7.44 0.38 8.78e-13 Neuroticism; LUSC trans rs10946292 0.706 rs3012448 chr6:170434734 C/T cg17832364 chr10:94847294 NA 0.39 6.44 0.33 4.2e-10 Obesity-related traits; LUSC trans rs561341 0.883 rs4795661 chr17:30201774 T/A cg20587970 chr11:113659929 NA 1.12 13.33 0.59 8.6e-33 Hip circumference adjusted for BMI; LUSC cis rs7937682 0.681 rs7107378 chr11:111401840 C/A cg09085632 chr11:111637200 PPP2R1B 0.53 6.94 0.35 2.07e-11 Primary sclerosing cholangitis; LUSC cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg19230755 chr7:65878503 NA 0.41 5.67 0.3 3.13e-8 Aortic root size; LUSC cis rs12594515 1.000 rs6493170 chr15:45987019 G/A cg01629716 chr15:45996671 NA 0.4 6.12 0.32 2.57e-9 Waist circumference;Weight; LUSC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg22862634 chr11:62369728 EML3;MTA2 0.62 9.61 0.47 1.84e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2274273 0.588 rs17675223 chr14:55862236 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.47 0.46 5.32e-19 Protein biomarker; LUSC trans rs28735056 0.904 rs11665111 chr18:77622996 T/C cg05926928 chr17:57297772 GDPD1 0.5 7.19 0.37 4.18e-12 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17042849 chr6:26104293 HIST1H4C -0.5 -6.04 -0.31 4.1e-9 Bipolar disorder and schizophrenia; LUSC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.91 -0.44 3.32e-17 Autism spectrum disorder or schizophrenia; LUSC cis rs4820294 1.000 rs78974622 chr22:38059925 A/C cg21798802 chr22:38057573 PDXP 0.48 10.53 0.5 1.4e-22 Fat distribution (HIV); LUSC cis rs868036 0.681 rs9920643 chr15:68104314 C/T cg08079166 chr15:68083412 MAP2K5 0.41 7.29 0.37 2.33e-12 Restless legs syndrome; LUSC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg18135555 chr8:22132992 PIWIL2 0.4 7.95 0.4 2.96e-14 Hypertriglyceridemia; LUSC cis rs67460515 0.892 rs16832082 chr3:161043571 A/G cg03342759 chr3:160939853 NMD3 -0.52 -7.51 -0.38 5.46e-13 Parkinson's disease; LUSC cis rs7954584 0.604 rs34159444 chr12:122416667 A/G cg13699009 chr12:122356056 WDR66 0.48 7.51 0.38 5.4e-13 Mean corpuscular volume; LUSC cis rs9395066 0.545 rs10948185 chr6:44901727 C/T cg25276700 chr6:44698697 NA 0.31 6.22 0.32 1.48e-9 Height; LUSC cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg00339695 chr16:24857497 SLC5A11 -0.42 -7.29 -0.37 2.31e-12 Intelligence (multi-trait analysis); LUSC cis rs8056893 0.714 rs1868159 chr16:68387496 G/T cg02226672 chr16:68398533 SMPD3 -0.32 -5.68 -0.3 2.91e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs6964587 0.692 rs10227225 chr7:91571074 A/G cg17063962 chr7:91808500 NA -0.57 -9.45 -0.46 6.08e-19 Breast cancer; LUSC cis rs1559088 0.847 rs3786933 chr19:33602881 C/T cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.03e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg02527881 chr3:46936655 PTH1R -0.4 -7.15 -0.36 5.37e-12 Colorectal cancer; LUSC cis rs868036 0.718 rs28399056 chr15:68116010 C/A cg08079166 chr15:68083412 MAP2K5 0.41 7.27 0.37 2.57e-12 Restless legs syndrome; LUSC cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg05347473 chr6:146136440 FBXO30 -0.56 -9.71 -0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg23711669 chr6:146136114 FBXO30 0.81 14.15 0.61 5.9e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs11758351 0.866 rs2069018 chr6:26205718 T/C cg23601095 chr6:26197514 HIST1H3D 0.72 7.7 0.39 1.51e-13 Gout;Renal underexcretion gout; LUSC cis rs2479724 0.901 rs6458244 chr6:41790455 C/T cg17623882 chr6:41773611 USP49 0.62 10.3 0.49 8.79e-22 Menarche (age at onset); LUSC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg11764359 chr7:65958608 NA -0.71 -11.04 -0.52 2.31e-24 Aortic root size; LUSC cis rs7771547 0.573 rs664370 chr6:36393816 A/G cg07856975 chr6:36356162 ETV7 0.34 6.2 0.32 1.69e-9 Platelet distribution width; LUSC cis rs8099014 0.906 rs11152071 chr18:56087417 T/C cg12907477 chr18:56117327 MIR122 0.44 6.9 0.35 2.61e-11 Platelet count; LUSC cis rs12801636 0.512 rs2075660 chr11:65414709 C/A cg24147428 chr11:65409760 SIPA1 -0.51 -5.89 -0.31 9.41e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.71 -0.3 2.45e-8 Depression; LUSC cis rs4363385 0.655 rs11205163 chr1:152983677 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.64 -0.39 2.38e-13 Inflammatory skin disease; LUSC cis rs11711311 1.000 rs9865435 chr3:113450046 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg27661571 chr11:113659931 NA -0.61 -6.92 -0.35 2.35e-11 Hip circumference adjusted for BMI; LUSC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg01448562 chr3:133502909 NA 0.66 10.32 0.49 7.17e-22 Iron status biomarkers; LUSC cis rs7917772 0.582 rs7907760 chr10:104345197 C/T cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs16912285 0.688 rs12801367 chr11:24321827 G/A ch.11.24196551F chr11:24239977 NA 0.9 9.55 0.46 2.86e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04175895 chr11:64851783 CDCA5;ZFPL1 -0.42 -6.29 -0.33 9.95e-10 Electrocardiographic conduction measures; LUSC cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg17063962 chr7:91808500 NA 0.6 9.43 0.46 7.12e-19 Breast cancer; LUSC cis rs17621444 0.522 rs4752371 chr10:121792095 G/A cg02041677 chr10:121771263 NA -0.34 -6.34 -0.33 7.31e-10 IgG glycosylation; LUSC cis rs7772486 0.875 rs2328712 chr6:146344563 T/C cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 9.18e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs9325144 0.647 rs870431 chr12:38953073 T/C cg13010199 chr12:38710504 ALG10B -0.5 -7.66 -0.39 2.08e-13 Morning vs. evening chronotype; LUSC cis rs12824058 0.844 rs10744458 chr12:130805820 C/T cg14604444 chr12:130766091 NA -0.33 -5.71 -0.3 2.49e-8 Menopause (age at onset); LUSC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs10484885 0.514 rs10944450 chr6:90228498 A/G cg13799429 chr6:90582589 CASP8AP2 -0.56 -5.87 -0.31 1.06e-8 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs1997103 1.000 rs6951294 chr7:55400835 C/T cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs7939886 0.920 rs12417606 chr11:55750479 C/T cg15704280 chr7:45808275 SEPT13 0.84 7.06 0.36 9.96e-12 Myopia (pathological); LUSC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs6901250 0.632 rs339355 chr6:117196503 A/T cg12892004 chr6:117198278 RFX6 -0.39 -7.56 -0.38 4.01e-13 C-reactive protein levels; LUSC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg08048268 chr3:133502702 NA 0.46 8.94 0.44 2.67e-17 Iron status biomarkers; LUSC cis rs8040855 0.599 rs1964724 chr15:85726500 G/C cg04831495 chr15:85060580 GOLGA6L5 0.41 6.89 0.35 2.72e-11 Bulimia nervosa; LUSC cis rs13082711 0.911 rs11718991 chr3:27452944 A/G cg02860705 chr3:27208620 NA 0.51 8.48 0.42 7.17e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg26513180 chr16:89883248 FANCA -0.54 -8.05 -0.4 1.46e-14 Vitiligo; LUSC cis rs4969178 0.832 rs4969185 chr17:76398157 G/C cg20026190 chr17:76395443 PGS1 0.45 8.02 0.4 1.82e-14 HDL cholesterol levels; LUSC cis rs372883 0.648 rs1153292 chr21:30689195 G/T cg24692254 chr21:30365293 RNF160 -0.7 -10.52 -0.5 1.56e-22 Pancreatic cancer; LUSC cis rs7917772 0.582 rs4917973 chr10:104333700 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 10.83 0.51 1.26e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs5753037 0.838 rs140149 chr22:30185613 C/T cg11564601 chr22:30592435 NA 0.34 6.02 0.31 4.5e-9 Type 1 diabetes; LUSC cis rs7804356 0.954 rs4722641 chr7:26838677 C/G cg03456212 chr7:26904342 SKAP2 -0.55 -6.55 -0.34 2.18e-10 Type 1 diabetes; LUSC cis rs9309711 0.961 rs35067331 chr2:3474085 C/T cg10845886 chr2:3471009 TTC15 -0.64 -8.37 -0.42 1.63e-15 Neurofibrillary tangles; LUSC cis rs9311676 0.656 rs11917591 chr3:58368449 C/T cg26110898 chr3:58419937 PDHB -0.42 -7.01 -0.36 1.29e-11 Systemic lupus erythematosus; LUSC cis rs983392 0.679 rs10736700 chr11:60031399 T/C cg20284999 chr11:59952153 MS4A6A 0.37 6.15 0.32 2.19e-9 Alzheimer's disease (late onset); LUSC cis rs4930103 0.590 rs3809101 chr11:1967271 C/T cg26856596 chr11:1961893 NA 0.35 6.91 0.35 2.47e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs12425451 0.544 rs1990330 chr12:3147462 A/C cg05389053 chr12:3131226 TEAD4 0.44 5.93 0.31 7.62e-9 Narcolepsy with cataplexy; LUSC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg06453172 chr10:134556979 INPP5A -0.5 -6.2 -0.32 1.64e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs453301 0.653 rs11784393 chr8:8903134 C/T cg06636001 chr8:8085503 FLJ10661 0.61 9.48 0.46 4.93e-19 Joint mobility (Beighton score); LUSC cis rs72960926 0.744 rs72968273 chr6:74893673 C/A cg03266952 chr6:74778945 NA -0.8 -6.32 -0.33 8.53e-10 Metabolite levels (MHPG); LUSC cis rs4700695 0.841 rs251305 chr5:65249859 C/T cg21114390 chr5:65439923 SFRS12 0.5 5.93 0.31 7.61e-9 Facial morphology (factor 19); LUSC cis rs3540 0.597 rs3743409 chr15:91045539 T/A cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.69 -0.3 2.8e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg11041457 chr3:52719354 GNL3;PBRM1 -0.36 -5.81 -0.3 1.44e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs34172651 0.917 rs6497756 chr16:24798291 G/T cg00339695 chr16:24857497 SLC5A11 0.36 6.28 0.33 1.03e-9 Intelligence (multi-trait analysis); LUSC cis rs3862030 0.839 rs2274351 chr10:104264107 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -9.88 -0.48 2.22e-20 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg23978390 chr7:1156363 C7orf50 0.42 5.7 0.3 2.63e-8 Longevity;Endometriosis; LUSC cis rs9467773 1.000 rs1078679 chr6:26568741 C/T cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg02423579 chr7:2872169 GNA12 -0.44 -6.33 -0.33 7.8e-10 Height; LUSC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -8.98 -0.44 1.99e-17 Gut microbiome composition (summer); LUSC cis rs965469 0.779 rs6037515 chr20:3233091 C/A cg25506879 chr20:3388711 C20orf194 -0.49 -5.65 -0.3 3.46e-8 IFN-related cytopenia; LUSC cis rs1028488 0.511 rs7762492 chr6:170704946 C/G cg20370364 chr6:170703943 FAM120B 0.48 7.14 0.36 5.92e-12 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs13089785 0.965 rs1920221 chr3:123606952 A/G cg02558132 chr3:123411198 MYLK 0.33 5.72 0.3 2.36e-8 Intelligence (multi-trait analysis); LUSC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg19230755 chr7:65878503 NA 0.41 5.76 0.3 1.95e-8 Aortic root size; LUSC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.55 7.48 0.38 6.49e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4604732 0.631 rs80319072 chr1:247626835 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs4780401 0.703 rs3190321 chr16:11773662 C/G cg01061890 chr16:11836724 TXNDC11 -0.44 -6.46 -0.33 3.78e-10 Rheumatoid arthritis; LUSC cis rs10197940 0.545 rs2444267 chr2:152308611 T/G cg19508488 chr2:152266495 RIF1 0.4 5.8 0.3 1.51e-8 Lung cancer; LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg18099408 chr3:52552593 STAB1 -0.4 -6.92 -0.35 2.26e-11 Bipolar disorder; LUSC cis rs7215564 0.908 rs36077104 chr17:78661757 T/A cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs7824557 0.602 rs11781375 chr8:11204532 A/G cg21293242 chr8:11204541 TDH 0.31 5.66 0.3 3.34e-8 Retinal vascular caliber; LUSC cis rs11864453 0.645 rs7194668 chr16:72128207 G/C cg16558253 chr16:72132732 DHX38 -0.37 -5.71 -0.3 2.46e-8 Fibrinogen levels; LUSC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg13770153 chr20:60521292 NA -1.02 -15.51 -0.65 3.14e-41 Obesity-related traits; LUSC cis rs6547741 1.000 rs4666009 chr2:27857992 T/A cg12559939 chr2:27858050 GPN1 0.41 6.39 0.33 5.68e-10 Oral cavity cancer; LUSC cis rs6545883 0.868 rs6748003 chr2:61806700 T/G cg15711740 chr2:61764176 XPO1 -0.47 -7.44 -0.38 8.42e-13 Tuberculosis; LUSC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.56 0.46 2.7e-19 Personality dimensions; LUSC cis rs1023500 0.552 rs5758566 chr22:42454354 G/A cg04733989 chr22:42467013 NAGA 0.62 9.67 0.47 1.19e-19 Schizophrenia; LUSC cis rs9420 0.884 rs644883 chr11:57663522 C/G cg02958346 chr11:57425731 CLP1 0.43 6.01 0.31 4.98e-9 Schizophrenia; LUSC trans rs4713118 0.699 rs200978 chr6:27853168 C/G cg05267876 chr1:229644265 NUP133 -0.48 -5.95 -0.31 6.91e-9 Parkinson's disease; LUSC cis rs796364 0.806 rs35200468 chr2:201110368 G/C cg23649088 chr2:200775458 C2orf69 -0.55 -6.51 -0.34 2.83e-10 Schizophrenia; LUSC cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg05347473 chr6:146136440 FBXO30 0.49 8.09 0.4 1.14e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs931812 0.535 rs3105452 chr8:101943618 A/G cg20993868 chr7:22813445 NA 0.34 6.26 0.32 1.17e-9 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg15790184 chr11:494944 RNH1 0.54 6.17 0.32 2e-9 Body mass index; LUSC cis rs75804782 0.641 rs57080728 chr2:239350487 T/C cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7605827 0.930 rs11692646 chr2:15559198 C/G cg19274914 chr2:15703543 NA -0.47 -8.99 -0.44 1.91e-17 Educational attainment (years of education); LUSC trans rs9951602 0.512 rs8085719 chr18:76649111 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.09 0.58 6.6e-32 Obesity-related traits; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg24739457 chr1:205821442 NA 0.35 6.07 0.32 3.56e-9 Menarche (age at onset); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg25080152 chr8:128748155 MYC 0.45 6.21 0.32 1.53e-9 Neuroticism; LUSC cis rs11030122 0.702 rs10835407 chr11:3993231 C/T cg08557956 chr11:4115526 RRM1 0.46 5.89 0.31 9.55e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg14433983 chr11:636460 DRD4 -0.37 -6.01 -0.31 4.77e-9 Systemic lupus erythematosus; LUSC cis rs2040771 0.774 rs9604935 chr22:19211665 C/T cg02655711 chr22:19163373 SLC25A1 0.47 8.4 0.42 1.32e-15 Metabolite levels (small molecules and protein measures); LUSC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg03060546 chr3:49711283 APEH 0.72 12.18 0.55 1.79e-28 Resting heart rate; LUSC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg06634786 chr22:41940651 POLR3H 0.52 6.13 0.32 2.55e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9309473 1.000 rs9653557 chr2:73795962 A/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.53 -0.34 2.47e-10 Metabolite levels; LUSC cis rs7945705 0.806 rs12224436 chr11:8815825 C/A cg09997546 chr11:8931473 C11orf17;ST5 0.36 7.09 0.36 7.94e-12 Hemoglobin concentration; LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg24642844 chr7:1081250 C7orf50 -0.8 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg13114125 chr14:105738426 BRF1 -0.94 -16.05 -0.66 2.29e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.69 0.51 3.77e-23 Menopause (age at onset); LUSC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg07507251 chr3:52567010 NT5DC2 0.33 6.54 0.34 2.28e-10 Bipolar disorder; LUSC cis rs4722404 0.560 rs6975818 chr7:3115520 C/G cg19214707 chr7:3157722 NA -0.39 -6.63 -0.34 1.35e-10 Atopic dermatitis; LUSC cis rs10740039 0.768 rs1372710 chr10:62362958 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.3e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1178968 0.901 rs2528705 chr7:72791238 A/G cg25889504 chr7:72793014 NA 0.59 7.35 0.37 1.59e-12 Triglyceride levels; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.7 10.71 0.51 3.4e-23 Lymphocyte counts; LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg06138931 chr13:21896616 NA 0.46 8.22 0.41 4.58e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs17125944 0.505 rs10483617 chr14:53202605 A/G cg13660082 chr14:53194042 PSMC6 0.73 6.34 0.33 7.41e-10 Alzheimer's disease (late onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01297191 chr7:22396644 RAPGEF5 -0.39 -5.97 -0.31 6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs16937 0.640 rs6664706 chr1:205182563 T/C cg00857998 chr1:205179979 DSTYK 0.4 5.83 0.3 1.34e-8 Schizophrenia; LUSC cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs8141529 0.732 rs5762788 chr22:29174770 G/T cg02153584 chr22:29168773 CCDC117 0.65 10.51 0.5 1.59e-22 Lymphocyte counts; LUSC cis rs711244 0.532 rs4670181 chr2:37226903 G/C cg14987922 chr2:37194071 STRN 0.5 7.22 0.37 3.44e-12 Mean platelet volume; LUSC cis rs4664304 0.658 rs2667016 chr2:160868855 C/T cg03641300 chr2:160917029 PLA2R1 -0.36 -6.04 -0.31 4.03e-9 Crohn's disease;Inflammatory bowel disease; LUSC trans rs12579753 0.917 rs7138895 chr12:82203280 T/G cg07923666 chr12:49932857 KCNH3 -0.49 -6.14 -0.32 2.29e-9 Resting heart rate; LUSC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.45 -0.38 8.3e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.4 -6.64 -0.34 1.28e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9323205 0.677 rs12586581 chr14:51722938 G/A cg23942311 chr14:51606299 NA -0.39 -7.19 -0.37 4.34e-12 Cancer; LUSC cis rs7223966 1.000 rs8067431 chr17:61817048 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.71 0.34 8.15e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05351087 chr6:151773080 C6orf211;RMND1 -0.43 -6.45 -0.33 3.98e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs7264396 0.570 rs6060717 chr20:34544647 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.81 -0.43 6.75e-17 Total cholesterol levels; LUSC cis rs17685 0.672 rs10952841 chr7:75778626 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg06637938 chr14:75390232 RPS6KL1 -0.51 -7.99 -0.4 2.27e-14 Height; LUSC cis rs9303401 0.659 rs7225896 chr17:56637337 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.72 0.57 1.68e-30 Cognitive test performance; LUSC cis rs9814567 0.762 rs13070654 chr3:134219348 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 11.91 0.55 1.75e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2692947 0.589 rs810057 chr2:97015073 T/C cg23100626 chr2:96804247 ASTL 0.26 6.21 0.32 1.6e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.56 0.38 3.9e-13 Colorectal cancer; LUSC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13256369 0.802 rs12541520 chr8:8564146 G/T cg00074818 chr8:8560427 CLDN23 0.55 9.42 0.46 7.91e-19 Obesity-related traits; LUSC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg22166914 chr1:53195759 ZYG11B 0.56 8.32 0.41 2.27e-15 Monocyte count; LUSC trans rs62238980 0.614 rs4289286 chr22:32458612 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg00684032 chr4:1343700 KIAA1530 0.47 8.33 0.41 2.19e-15 Obesity-related traits; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg21782813 chr7:2030301 MAD1L1 0.34 5.67 0.3 3.08e-8 Bipolar disorder and schizophrenia; LUSC cis rs4974559 0.641 rs28647383 chr4:1312908 G/C cg02980000 chr4:1222292 CTBP1 1.04 9.52 0.46 3.61e-19 Systolic blood pressure; LUSC cis rs4343996 0.558 rs7798141 chr7:3413024 A/G cg21248987 chr7:3385318 SDK1 0.37 6.23 0.32 1.38e-9 Motion sickness; LUSC cis rs13418410 0.715 rs10201046 chr2:33794438 A/G cg04131969 chr2:33951647 MYADML -0.45 -5.99 -0.31 5.32e-9 Non-response to antidepressants and depression; LUSC cis rs4423214 0.879 rs736894 chr11:71152258 A/G cg05163923 chr11:71159392 DHCR7 0.69 9.31 0.45 1.72e-18 Vitamin D levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04996852 chr16:3930112 CREBBP -0.39 -5.96 -0.31 6.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2387326 0.671 rs12268728 chr10:129945897 G/A cg16087940 chr10:129947807 NA -0.4 -6.12 -0.32 2.59e-9 Select biomarker traits; LUSC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg07716408 chr11:68623521 NA -0.31 -5.86 -0.31 1.09e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg06671706 chr8:8559999 CLDN23 0.51 6.71 0.34 8.45e-11 Obesity-related traits; LUSC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg19920283 chr7:105172520 RINT1 0.57 6.08 0.32 3.34e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.45 -6.4 -0.33 5.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7819412 1.000 rs2409722 chr8:11039816 T/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.78 -0.39 9e-14 Triglycerides; LUSC cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg18721089 chr20:30220636 NA 0.35 5.91 0.31 8.53e-9 Mean corpuscular hemoglobin; LUSC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.67 8.69 0.43 1.71e-16 Schizophrenia; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg00149659 chr3:10157352 C3orf10 0.97 13.53 0.6 1.45e-33 Alzheimer's disease; LUSC cis rs4919694 1.000 rs80327774 chr10:104656671 T/C cg04362960 chr10:104952993 NT5C2 1.15 13.48 0.59 2.28e-33 Arsenic metabolism; LUSC cis rs3806843 0.518 rs2563310 chr5:140015741 A/G cg26395211 chr5:140044315 WDR55 0.41 6.37 0.33 6.09e-10 Depressive symptoms (multi-trait analysis); LUSC cis rs11209002 0.614 rs6670381 chr1:67562106 G/T cg02640540 chr1:67518911 SLC35D1 0.64 9.11 0.45 7.99e-18 Crohn's disease; LUSC cis rs9920506 0.536 rs12441998 chr15:78929372 G/A cg24631222 chr15:78858424 CHRNA5 -0.55 -7.03 -0.36 1.17e-11 Post bronchodilator FEV1; LUSC cis rs6430585 0.527 rs7592050 chr2:136459227 C/T cg07169764 chr2:136633963 MCM6 -1.04 -13.8 -0.6 1.35e-34 Corneal structure; LUSC cis rs9650315 0.866 rs7825725 chr8:57172347 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.48 6.38 0.33 5.94e-10 Height; LUSC trans rs800082 1.000 rs4681378 chr3:144308005 C/T cg24215973 chr2:240111563 HDAC4 -0.47 -7.02 -0.36 1.21e-11 Smoking behavior; LUSC cis rs1865760 0.622 rs9295685 chr6:26071725 G/C cg16482183 chr6:26056742 HIST1H1C 0.55 8.2 0.41 5.32e-15 Height; LUSC cis rs12200560 0.505 rs11153095 chr6:97078592 T/C cg06623918 chr6:96969491 KIAA0776 -0.48 -6.94 -0.35 2.09e-11 Coronary heart disease; LUSC cis rs7572644 1.000 rs7581813 chr2:28319961 G/T cg27432699 chr2:27873401 GPN1 0.51 6.19 0.32 1.72e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4356932 1.000 rs7674409 chr4:76958334 C/G cg00809888 chr4:76862425 NAAA -0.35 -5.77 -0.3 1.79e-8 Blood protein levels; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg02033258 chr5:131593261 PDLIM4 0.4 5.76 0.3 1.92e-8 Acylcarnitine levels; LUSC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg13298116 chr11:62369859 EML3;MTA2 0.59 9.61 0.47 1.83e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs62400317 0.859 rs12191262 chr6:45227016 G/A cg18551225 chr6:44695536 NA -0.45 -7.37 -0.37 1.38e-12 Total body bone mineral density; LUSC cis rs73206853 0.841 rs3759382 chr12:110889483 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4776059 0.550 rs73396766 chr15:52911516 C/T cg22715398 chr15:52968154 KIAA1370 0.71 7.8 0.39 8.14e-14 Schizophrenia; LUSC cis rs698813 0.604 rs58667148 chr2:44481443 G/A cg00619915 chr2:44497795 NA -0.53 -7.52 -0.38 5e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg09177884 chr7:1199841 ZFAND2A -0.54 -7.31 -0.37 1.94e-12 Longevity;Endometriosis; LUSC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.08 0.36 8.55e-12 Hip circumference adjusted for BMI; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg24739457 chr1:205821442 NA 0.41 7.28 0.37 2.46e-12 Menarche (age at onset); LUSC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg12463550 chr7:65579703 CRCP -0.42 -6.17 -0.32 1.98e-9 Aortic root size; LUSC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg03605463 chr16:89740564 NA 0.6 9.57 0.46 2.5e-19 Vitiligo; LUSC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11890956 chr21:40555474 PSMG1 -0.74 -11.24 -0.52 4.55e-25 Menarche (age at onset); LUSC cis rs9300255 0.537 rs1790101 chr12:123704844 T/C cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg21856205 chr7:94953877 PON1 -0.55 -10.99 -0.52 3.55e-24 Paraoxonase activity; LUSC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg14829155 chr15:31115871 NA -0.57 -7.95 -0.4 2.98e-14 Huntington's disease progression; LUSC cis rs9341808 0.519 rs607130 chr6:80999233 T/C cg08355045 chr6:80787529 NA -0.4 -6.92 -0.35 2.36e-11 Sitting height ratio; LUSC cis rs7843479 0.965 rs1564305 chr8:21803816 A/C cg17168535 chr8:21777572 XPO7 0.67 10.34 0.49 6.11e-22 Mean corpuscular volume; LUSC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg07777115 chr5:623756 CEP72 -0.45 -5.7 -0.3 2.62e-8 Obesity-related traits; LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg20887711 chr4:1340912 KIAA1530 -0.65 -10.17 -0.49 2.43e-21 Obesity-related traits; LUSC cis rs2692947 0.644 rs1168968 chr2:96825363 C/T cg23100626 chr2:96804247 ASTL 0.3 7.23 0.37 3.22e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg14133921 chr5:54831061 PPAP2A;RNF138P1 0.53 6.17 0.32 1.94e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11997175 0.704 rs11775534 chr8:33695232 G/A ch.8.33884649F chr8:33765107 NA 0.37 5.8 0.3 1.5e-8 Body mass index; LUSC cis rs6690583 0.623 rs75918067 chr1:85453413 T/C cg11262906 chr1:85462892 MCOLN2 0.68 6.56 0.34 2.02e-10 Serum sulfate level; LUSC cis rs13191362 0.507 rs2849534 chr6:163144657 T/A cg21926612 chr6:163149169 PACRG;PARK2 -0.64 -9.76 -0.47 5.61e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg14019146 chr3:50243930 SLC38A3 0.31 6.94 0.35 2.1e-11 Intelligence (multi-trait analysis); LUSC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs10911232 0.507 rs6672306 chr1:183058898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.7 10.8 0.51 1.61e-23 Hypertriglyceridemia; LUSC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg08975724 chr8:8085496 FLJ10661 0.53 8.1 0.41 1.02e-14 Mood instability; LUSC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg01802117 chr1:53393560 SCP2 0.39 6.47 0.33 3.49e-10 Monocyte count; LUSC cis rs7267979 0.903 rs2474766 chr20:25246153 A/G cg08601574 chr20:25228251 PYGB 0.49 7.53 0.38 4.75e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11252926 0.931 rs4881399 chr10:567325 A/G cg18196295 chr10:418757 DIP2C 0.38 5.95 0.31 6.63e-9 Psychosis in Alzheimer's disease; LUSC cis rs12618769 0.652 rs4851145 chr2:99222916 A/G cg10123293 chr2:99228465 UNC50 -0.45 -7.25 -0.37 3e-12 Bipolar disorder; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs9517313 0.592 rs11069311 chr13:99202101 G/T cg20487152 chr13:99095054 FARP1 -0.41 -7.0 -0.36 1.45e-11 Neuroticism; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03146073 chr3:44519063 ZNF445 -0.42 -6.26 -0.32 1.15e-9 Electrocardiographic conduction measures; LUSC cis rs6750795 0.765 rs6742387 chr2:232354832 G/T cg19187155 chr2:232395269 NMUR1 0.94 16.14 0.66 9.67e-44 Height; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg25767906 chr1:53392781 SCP2 -0.54 -9.49 -0.46 4.52e-19 Monocyte count; LUSC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.55 0.34 2.17e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.79 0.39 8.3e-14 Lymphocyte counts; LUSC trans rs853679 0.599 rs149949 chr6:28011516 T/C cg01620082 chr3:125678407 NA -0.58 -6.62 -0.34 1.42e-10 Depression; LUSC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg24209194 chr3:40518798 ZNF619 0.45 6.1 0.32 2.87e-9 Renal cell carcinoma; LUSC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg01097406 chr16:89675127 NA -0.34 -6.52 -0.34 2.64e-10 Vitiligo; LUSC cis rs9549367 0.789 rs3850451 chr13:113905812 C/G cg00898013 chr13:113819073 PROZ -0.58 -8.23 -0.41 4.15e-15 Platelet distribution width; LUSC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.32 5.81 0.3 1.43e-8 Bone mineral density (hip);Bone mineral density; LUSC cis rs6669072 0.669 rs712031 chr1:91243395 A/G cg08895590 chr1:91227319 NA -0.39 -8.7 -0.43 1.56e-16 Cognitive function; LUSC cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg01689657 chr7:91764605 CYP51A1 0.33 5.94 0.31 7.15e-9 Breast cancer; LUSC cis rs11098499 0.575 rs9996586 chr4:120326942 A/G cg24375607 chr4:120327624 NA 0.48 7.47 0.38 7.24e-13 Corneal astigmatism; LUSC cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6121246 0.529 rs750144 chr20:30179027 C/T cg21427119 chr20:30132790 HM13 0.42 5.97 0.31 6.01e-9 Mean corpuscular hemoglobin; LUSC cis rs7107174 1.000 rs4944198 chr11:78032605 T/A cg02023728 chr11:77925099 USP35 0.47 7.02 0.36 1.28e-11 Testicular germ cell tumor; LUSC cis rs2386661 0.547 rs4747358 chr10:5650193 A/G cg17085576 chr10:5658249 NA 0.43 6.22 0.32 1.46e-9 Breast cancer; LUSC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg13047869 chr3:10149882 C3orf24 0.44 6.71 0.34 8.55e-11 Alzheimer's disease; LUSC cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg05347473 chr6:146136440 FBXO30 0.54 9.27 0.45 2.34e-18 Lobe attachment (rater-scored or self-reported); LUSC trans rs4332037 0.851 rs28728306 chr7:1961814 C/A cg25206134 chr2:45395956 NA 0.59 6.79 0.35 5.05e-11 Bipolar disorder; LUSC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg11843238 chr5:131593191 PDLIM4 0.38 6.6 0.34 1.62e-10 Breast cancer; LUSC cis rs12908161 1.000 rs4643294 chr15:85250253 C/T cg17507749 chr15:85114479 UBE2QP1 0.56 6.91 0.35 2.45e-11 Schizophrenia; LUSC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg07701084 chr6:150067640 NUP43 0.57 8.87 0.44 4.47e-17 Lung cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25373372 chr6:82462656 FAM46A -0.46 -6.33 -0.33 7.93e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg19812747 chr11:111475976 SIK2 -0.55 -8.18 -0.41 5.92e-15 Primary sclerosing cholangitis; LUSC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg18681998 chr4:17616180 MED28 0.92 18.02 0.7 3.46e-51 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9527 0.615 rs9733635 chr10:104711940 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.35 0.46 1.32e-18 Arsenic metabolism; LUSC cis rs2276314 0.857 rs28540805 chr18:33641975 T/G cg05985134 chr18:33552581 C18orf21 0.49 6.68 0.34 1.03e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg13393036 chr8:95962371 TP53INP1 -0.46 -10.15 -0.49 2.77e-21 Type 2 diabetes; LUSC cis rs1107366 1.000 rs1107364 chr3:125904263 G/A cg01346077 chr3:125931526 NA 0.37 7.07 0.36 9.34e-12 Metabolite levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17144508 chr2:128283727 IWS1 -0.41 -6.08 -0.32 3.36e-9 Hepatitis; LUSC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11890956 chr21:40555474 PSMG1 -0.92 -16.68 -0.67 7.22e-46 Cognitive function; LUSC cis rs2281845 0.929 rs7549337 chr1:201097609 T/G cg17810781 chr1:201082982 CACNA1S 0.32 5.74 0.3 2.1e-8 Permanent tooth development; LUSC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs614226 0.938 rs7972244 chr12:120994872 A/G cg01236616 chr12:121019343 POP5 1.32 21.88 0.77 1.84e-66 Type 1 diabetes nephropathy; LUSC cis rs9325144 0.560 rs11182930 chr12:38633693 A/T cg13010199 chr12:38710504 ALG10B -0.53 -7.9 -0.4 3.98e-14 Morning vs. evening chronotype; LUSC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg26850624 chr5:429559 AHRR -0.43 -8.43 -0.42 1.08e-15 Cystic fibrosis severity; LUSC cis rs72781680 1.000 rs72796339 chr2:24143063 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs9818941 0.784 rs7614747 chr3:157750934 T/C cg08654915 chr3:157813417 NA -0.33 -7.51 -0.38 5.42e-13 Height; LUSC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg08847533 chr14:75593920 NEK9 0.86 15.55 0.65 2.15e-41 Height; LUSC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.17 -0.32 1.96e-9 Alzheimer's disease (late onset); LUSC cis rs7071206 0.853 rs57420220 chr10:79428886 C/T cg07817648 chr10:79422355 NA -0.54 -7.46 -0.38 7.49e-13 Bone mineral density; LUSC cis rs8062405 0.721 rs151181 chr16:28490517 A/G cg16576597 chr16:28551801 NUPR1 0.28 5.73 0.3 2.23e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11662586 0.517 rs7230837 chr18:77695384 A/T cg20368463 chr18:77673604 PQLC1 0.79 13.99 0.61 2.53e-35 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC trans rs9329221 0.537 rs13264586 chr8:9979385 T/C cg21775007 chr8:11205619 TDH 0.46 6.53 0.34 2.4e-10 Neuroticism; LUSC cis rs4363385 0.818 rs1334850 chr1:153004519 G/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.46e-8 Inflammatory skin disease; LUSC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg04944784 chr2:26401820 FAM59B 0.73 9.85 0.47 2.93e-20 Gut microbiome composition (summer); LUSC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg15691649 chr6:25882328 NA -0.38 -6.11 -0.32 2.8e-9 Blood metabolite levels; LUSC cis rs7223966 0.921 rs11655493 chr17:61733052 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 6.53 0.34 2.43e-10 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg15556689 chr8:8085844 FLJ10661 -0.54 -8.34 -0.42 2e-15 Systolic blood pressure; LUSC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21659725 chr3:3221576 CRBN -0.88 -18.04 -0.7 2.96e-51 Intelligence (multi-trait analysis); LUSC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg04287289 chr16:89883240 FANCA 0.76 6.26 0.32 1.19e-9 Skin colour saturation; LUSC cis rs9831754 0.704 rs9882111 chr3:78470746 A/G cg06138941 chr3:78371609 NA -0.52 -6.94 -0.35 2.08e-11 Calcium levels; LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg20607798 chr8:58055168 NA 0.53 5.93 0.31 7.73e-9 Developmental language disorder (linguistic errors); LUSC trans rs11992162 0.967 rs7461062 chr8:11831948 T/C cg27411982 chr8:10470053 RP1L1 0.51 7.75 0.39 1.09e-13 Monocyte count; LUSC cis rs2274273 0.840 rs17674463 chr14:55824863 A/T cg04306507 chr14:55594613 LGALS3 0.53 11.91 0.55 1.69e-27 Protein biomarker; LUSC cis rs2273669 0.667 rs11153154 chr6:109357324 G/T cg05315195 chr6:109294784 ARMC2 -0.53 -5.84 -0.3 1.22e-8 Prostate cancer; LUSC cis rs8025790 0.508 rs4776943 chr15:67836069 T/C cg24579218 chr15:68104479 NA -0.35 -5.74 -0.3 2.12e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg14159672 chr1:205819179 PM20D1 0.73 12.34 0.56 4.47e-29 Menarche (age at onset); LUSC cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg06671706 chr8:8559999 CLDN23 0.49 6.68 0.34 9.77e-11 Obesity-related traits; LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.94 0.48 1.4e-20 Bipolar disorder; LUSC trans rs208520 0.690 rs207112 chr6:66792092 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC cis rs2625529 0.824 rs10518979 chr15:72268986 A/G cg16672083 chr15:72433130 SENP8 -0.51 -7.41 -0.38 1.02e-12 Red blood cell count; LUSC cis rs11190604 1.000 rs9420785 chr10:102240451 C/G cg07080220 chr10:102295463 HIF1AN 0.64 8.57 0.42 3.92e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6669072 0.967 rs12130887 chr1:91240696 G/T cg08895590 chr1:91227319 NA -0.38 -8.51 -0.42 5.8e-16 Cognitive function; LUSC cis rs4423214 0.592 rs7114252 chr11:71237606 G/A cg05163923 chr11:71159392 DHCR7 -0.69 -7.12 -0.36 6.62e-12 Vitamin D levels; LUSC cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg22709100 chr7:91322751 NA 0.41 5.91 0.31 8.38e-9 Breast cancer; LUSC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs2820315 1.000 rs1517810 chr1:201850057 T/C cg10061532 chr1:201886748 LMOD1 0.26 5.85 0.3 1.17e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs7315438 0.600 rs10850515 chr12:115873190 C/G cg24172291 chr12:115889509 NA -0.33 -5.72 -0.3 2.4e-8 Colorectal cancer; LUSC trans rs11992162 1.000 rs7460395 chr8:11835375 C/T cg08975724 chr8:8085496 FLJ10661 0.46 6.22 0.32 1.51e-9 Monocyte count; LUSC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg22529645 chr1:3704559 LRRC47 0.37 6.43 0.33 4.48e-10 Red cell distribution width; LUSC cis rs6961069 0.713 rs1049654 chr7:80275455 A/C cg04458919 chr7:80252533 CD36 0.34 6.01 0.31 4.74e-9 Platelet count; LUSC cis rs9814567 0.762 rs13067564 chr3:134209956 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 12.1 0.55 3.54e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11971779 0.618 rs10085814 chr7:139064089 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs11992162 0.636 rs11250182 chr8:11807576 A/T cg21775007 chr8:11205619 TDH -0.43 -6.09 -0.32 3.09e-9 Monocyte count; LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.06 -0.58 8.6e-32 Alzheimer's disease; LUSC cis rs9398803 0.835 rs4897182 chr6:126755642 A/C cg19875578 chr6:126661172 C6orf173 0.42 6.26 0.32 1.18e-9 Male-pattern baldness; LUSC cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg26306683 chr17:18585705 ZNF286B 0.45 6.57 0.34 1.98e-10 Educational attainment (years of education); LUSC trans rs11992162 0.569 rs11786149 chr8:11800818 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.11 -0.32 2.79e-9 Monocyte count; LUSC cis rs4343996 0.811 rs6462030 chr7:3392526 G/A cg21248987 chr7:3385318 SDK1 -0.4 -6.79 -0.35 5.07e-11 Motion sickness; LUSC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg08999081 chr20:33150536 PIGU 0.53 10.54 0.5 1.34e-22 Coronary artery disease; LUSC trans rs1941687 0.527 rs2000945 chr18:31365336 A/G cg27147174 chr7:100797783 AP1S1 -0.63 -10.21 -0.49 1.8e-21 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg14844989 chr11:31128820 NA -0.37 -5.74 -0.3 2.16e-8 Red blood cell count; LUSC cis rs9902453 0.845 rs7222842 chr17:28246943 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.63 9.73 0.47 7.04e-20 Coffee consumption (cups per day); LUSC cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg13010199 chr12:38710504 ALG10B 0.65 9.81 0.47 3.95e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs8092503 1.000 rs12957162 chr18:52484299 T/A cg12377874 chr18:52495404 RAB27B 0.33 5.83 0.3 1.32e-8 Childhood body mass index; LUSC cis rs2908197 0.866 rs2961048 chr7:75935008 A/T cg10167463 chr7:75959203 YWHAG -0.39 -5.75 -0.3 1.96e-8 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg04025307 chr7:1156635 C7orf50 0.44 6.98 0.36 1.56e-11 Longevity;Endometriosis; LUSC cis rs208520 0.955 rs9345808 chr6:67008262 C/T cg07460842 chr6:66804631 NA 0.75 9.35 0.46 1.34e-18 Exhaled nitric oxide output; LUSC cis rs59698941 0.550 rs12652469 chr5:132182765 A/G cg14825688 chr5:132208181 LEAP2 -0.43 -6.29 -0.33 9.85e-10 Apolipoprotein A-IV levels; LUSC cis rs240764 0.853 rs17303769 chr6:100967531 G/A cg09795085 chr6:101329169 ASCC3 -0.41 -6.0 -0.31 5e-9 Neuroticism; LUSC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg11764359 chr7:65958608 NA 0.49 6.09 0.32 3.19e-9 Aortic root size; LUSC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg21918786 chr6:109611834 NA -0.38 -6.47 -0.33 3.45e-10 Reticulocyte fraction of red cells; LUSC cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg15839431 chr19:19639596 YJEFN3 -0.59 -6.32 -0.33 8.21e-10 Bipolar disorder; LUSC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg27398817 chr8:82754497 SNX16 0.5 6.75 0.35 6.75e-11 Diastolic blood pressure; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13077517 chr20:2082435 STK35 -0.39 -6.01 -0.31 4.74e-9 Hepatitis; LUSC cis rs4629180 1.000 rs4629180 chr2:102088370 G/A cg04415270 chr2:102091202 RFX8 -0.54 -8.66 -0.43 2e-16 Chronic rhinosinusitis with nasal polyps; LUSC cis rs11264213 0.901 rs72661623 chr1:36398368 G/A cg27506609 chr1:36549197 TEKT2 0.68 7.88 0.4 4.58e-14 Schizophrenia; LUSC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg24531977 chr5:56204891 C5orf35 -0.65 -9.66 -0.47 1.27e-19 Coronary artery disease; LUSC cis rs12594515 1.000 rs12592190 chr15:45994028 G/A cg01629716 chr15:45996671 NA 0.39 5.76 0.3 1.89e-8 Waist circumference;Weight; LUSC cis rs6460942 0.908 rs7781919 chr7:12235351 T/C cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg25072359 chr17:41440525 NA -0.61 -8.55 -0.42 4.36e-16 Menopause (age at onset); LUSC cis rs13720 0.722 rs163801 chr20:57578614 A/G cg23907860 chr20:57583709 CTSZ -0.49 -6.47 -0.33 3.5e-10 Platelet distribution width; LUSC cis rs7666738 0.519 rs28539191 chr4:98821552 C/T cg17366294 chr4:99064904 C4orf37 0.57 8.69 0.43 1.59e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9420 0.961 rs79260745 chr11:57612960 T/C cg02958346 chr11:57425731 CLP1 -0.43 -6.22 -0.32 1.51e-9 Schizophrenia; LUSC cis rs10189230 0.967 rs12990760 chr2:222354725 G/T cg14652038 chr2:222343519 EPHA4 0.32 5.72 0.3 2.35e-8 Urate levels in lean individuals; LUSC cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg25258033 chr6:167368657 RNASET2 0.4 6.06 0.31 3.7e-9 Primary biliary cholangitis; LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -5.9 -0.31 8.78e-9 Developmental language disorder (linguistic errors); LUSC cis rs849898 1 rs849898 chr1:228153917 A/G cg18477163 chr1:228402036 OBSCN -0.46 -7.66 -0.39 1.98e-13 Parkinson's disease; LUSC cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg26695010 chr11:65641043 EFEMP2 0.53 7.9 0.4 4.12e-14 Eosinophil percentage of white cells; LUSC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg06634786 chr22:41940651 POLR3H 0.49 5.69 0.3 2.72e-8 Vitiligo; LUSC cis rs2303282 0.664 rs67179399 chr16:56440201 G/A cg00500540 chr16:56394104 NA -0.39 -6.7 -0.34 8.98e-11 Breast cancer; LUSC cis rs10463316 0.832 rs246482 chr5:150731857 C/G cg03212797 chr5:150827313 SLC36A1 -0.52 -7.75 -0.39 1.13e-13 Metabolite levels (Pyroglutamine); LUSC cis rs6541297 0.793 rs6692319 chr1:230284375 C/T cg20703242 chr1:230279135 GALNT2 0.57 8.88 0.44 4.15e-17 Coronary artery disease; LUSC cis rs7100689 0.646 rs1934696 chr10:82124966 T/C cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg02175503 chr12:58329896 NA 0.47 6.78 0.35 5.5e-11 Intelligence (multi-trait analysis); LUSC cis rs3862435 1.000 rs3862436 chr15:91082869 A/G cg22089800 chr15:90895588 ZNF774 -0.6 -5.88 -0.31 1.01e-8 Response to exercise (triglyceride level interaction); LUSC cis rs793571 0.544 rs383902 chr15:59034174 C/T cg05156742 chr15:59063176 FAM63B 0.51 7.6 0.38 2.93e-13 Schizophrenia; LUSC trans rs2285002 0.744 rs229673 chr14:65281944 A/G cg15123499 chr10:636241 DIP2C 0.32 6.03 0.31 4.31e-9 Red cell distribution width; LUSC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg22907277 chr7:1156413 C7orf50 0.72 10.27 0.49 1.06e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11758351 0.518 rs78871852 chr6:26221566 A/T cg23601095 chr6:26197514 HIST1H3D 0.68 7.42 0.38 9.69e-13 Gout;Renal underexcretion gout; LUSC cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg05283184 chr6:79620031 NA -0.5 -9.68 -0.47 1.09e-19 Intelligence (multi-trait analysis); LUSC cis rs1801251 1.000 rs2674839 chr2:233669040 G/C cg25237894 chr2:233734115 C2orf82 0.35 6.54 0.34 2.32e-10 Coronary artery disease; LUSC cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.35 0.33 7.22e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg09323728 chr8:95962352 TP53INP1 -0.29 -5.72 -0.3 2.39e-8 Type 2 diabetes; LUSC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg11941060 chr3:133502564 NA -0.51 -7.94 -0.4 3.11e-14 Iron status biomarkers; LUSC cis rs2295359 0.892 rs10889657 chr1:67615487 A/G cg17031739 chr1:67600172 NA 0.44 6.94 0.35 2.08e-11 Psoriasis; LUSC trans rs656319 0.638 rs670044 chr8:9892529 G/T cg06636001 chr8:8085503 FLJ10661 0.43 6.53 0.34 2.52e-10 Myopia (pathological); LUSC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg12257692 chr3:49977190 RBM6 -0.25 -6.99 -0.36 1.54e-11 Body mass index; LUSC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg06634786 chr22:41940651 POLR3H 0.49 5.73 0.3 2.21e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.4 0.38 1.14e-12 Motion sickness; LUSC cis rs7927592 0.913 rs7102898 chr11:68328870 G/A cg01657329 chr11:68192670 LRP5 -0.4 -5.73 -0.3 2.28e-8 Total body bone mineral density; LUSC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.18e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.8 -0.47 4.27e-20 Gut microbiome composition (summer); LUSC cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.64 0.75 1.34e-61 Cognitive ability; LUSC cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg08085267 chr17:45401833 C17orf57 0.57 9.53 0.46 3.25e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11031096 0.782 rs2284450 chr11:4149214 A/T cg08557956 chr11:4115526 RRM1 -0.42 -5.67 -0.3 3.02e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs11587682 0.760 rs11205383 chr1:150455813 T/C cg11822372 chr1:151115635 SEMA6C -0.42 -5.71 -0.3 2.53e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg06481639 chr22:41940642 POLR3H -0.55 -6.24 -0.32 1.33e-9 Vitiligo; LUSC trans rs8072100 1.000 rs11870935 chr17:45732605 G/A cg03886242 chr7:26192032 NFE2L3 0.38 6.35 0.33 6.95e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14865585 chr21:45363474 AGPAT3 0.4 6.17 0.32 1.94e-9 Hepatitis; LUSC cis rs9816226 0.618 rs1516728 chr3:185829891 A/T cg00760338 chr3:185826511 ETV5 0.75 12.5 0.56 1.16e-29 Obesity;Body mass index; LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg18876405 chr7:65276391 NA 0.57 9.31 0.45 1.82e-18 Aortic root size; LUSC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.46 0.53 7.03e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs12908161 0.959 rs34784022 chr15:85231906 T/C cg17173187 chr15:85201210 NMB 0.51 9.66 0.47 1.24e-19 Schizophrenia; LUSC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg11812906 chr14:75593930 NEK9 -0.63 -10.19 -0.49 2.14e-21 Height; LUSC cis rs6736093 1.000 rs7604403 chr2:112656652 G/A cg12686935 chr2:112915763 FBLN7 -0.39 -6.06 -0.31 3.58e-9 Coronary artery disease; LUSC trans rs3808502 0.549 rs11991139 chr8:11428395 C/T cg15556689 chr8:8085844 FLJ10661 -0.65 -9.79 -0.47 4.74e-20 Neuroticism; LUSC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg00509249 chr6:109615579 CCDC162 0.31 5.66 0.3 3.28e-8 Reticulocyte fraction of red cells; LUSC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.49e-10 Extrinsic epigenetic age acceleration; LUSC cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg13010199 chr12:38710504 ALG10B 0.7 11.84 0.54 2.97e-27 Heart rate; LUSC cis rs5167 0.750 rs3786505 chr19:45490570 A/G cg13119609 chr19:45449297 APOC2 0.33 5.75 0.3 2.05e-8 Blood protein levels; LUSC cis rs12042938 0.935 rs1094657 chr1:231773407 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.43 6.28 0.33 1.05e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg08742575 chr21:47604166 C21orf56 -0.44 -6.58 -0.34 1.83e-10 Testicular germ cell tumor; LUSC trans rs12165098 0.673 rs4416086 chr18:36748710 C/T cg23858286 chr9:138135095 NA -0.42 -6.18 -0.32 1.84e-9 Sleep duration; LUSC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.68 -10.57 -0.5 1.01e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2404602 0.692 rs36070630 chr15:76949259 T/C cg22467129 chr15:76604101 ETFA -0.42 -6.6 -0.34 1.65e-10 Blood metabolite levels; LUSC cis rs9527 0.568 rs1926036 chr10:104883812 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg09626299 chr10:82213104 TSPAN14 -0.2 -5.8 -0.3 1.55e-8 Post bronchodilator FEV1; LUSC cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg00631329 chr6:26305371 NA -0.44 -8.61 -0.43 2.92e-16 Educational attainment; LUSC cis rs9807989 0.801 rs10173193 chr2:102975050 G/A cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg00933542 chr6:150070202 PCMT1 0.34 6.95 0.36 1.89e-11 Lung cancer; LUSC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg15110403 chr19:17392923 ANKLE1 -0.51 -6.96 -0.36 1.75e-11 Systemic lupus erythematosus; LUSC cis rs34779708 0.898 rs11595898 chr10:35326263 T/C cg03585969 chr10:35415529 CREM 0.6 8.67 0.43 1.86e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg23758822 chr17:41437982 NA 1.04 20.09 0.74 2.02e-59 Menopause (age at onset); LUSC cis rs1997103 1.000 rs2331063 chr7:55408914 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1178127 0.580 rs1178175 chr7:18797629 C/T cg02370815 chr7:18831390 HDAC9 -0.39 -5.82 -0.3 1.34e-8 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); LUSC cis rs859767 0.741 rs1104802 chr2:135436366 A/C cg12500956 chr2:135428796 TMEM163 -0.29 -6.48 -0.33 3.27e-10 Neuroticism; LUSC cis rs11637445 0.677 rs3784716 chr15:68084450 G/T cg08079166 chr15:68083412 MAP2K5 0.36 7.42 0.38 9.86e-13 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9534288 0.797 rs2806922 chr13:46518059 A/G cg15192986 chr13:46630673 CPB2 -0.61 -10.23 -0.49 1.52e-21 Blood protein levels; LUSC cis rs12681288 0.550 rs76893867 chr8:962618 G/C cg15309053 chr8:964076 NA 0.4 7.97 0.4 2.46e-14 Schizophrenia; LUSC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg02951883 chr7:2050386 MAD1L1 -0.42 -7.2 -0.37 4.1e-12 Bipolar disorder and schizophrenia; LUSC cis rs7953249 0.656 rs2178463 chr12:121389721 A/G cg02403541 chr12:121454288 C12orf43 -0.74 -11.4 -0.53 1.21e-25 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg03676636 chr4:99064102 C4orf37 0.37 8.14 0.41 7.81e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg08219700 chr8:58056026 NA 0.66 8.1 0.41 1.01e-14 Developmental language disorder (linguistic errors); LUSC cis rs11158026 0.757 rs6572994 chr14:55427103 C/G cg04306507 chr14:55594613 LGALS3 0.34 6.54 0.34 2.36e-10 Parkinson's disease; LUSC cis rs7568458 0.636 rs11126995 chr2:85792408 A/T cg17127132 chr2:85788382 GGCX 0.44 6.41 0.33 5.1e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg17328964 chr8:145687451 CYHR1 -0.66 -11.45 -0.53 7.59e-26 Age at first birth; LUSC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg19052272 chr2:3704530 ALLC -0.46 -7.58 -0.38 3.35e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs9467773 0.869 rs1796520 chr6:26410800 C/T cg09904177 chr6:26538194 HMGN4 -0.65 -10.61 -0.5 7.6e-23 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg22535103 chr8:58192502 C8orf71 -0.76 -7.99 -0.4 2.26e-14 Developmental language disorder (linguistic errors); LUSC cis rs6574644 1.000 rs10138868 chr14:81776770 T/G cg01989461 chr14:81687754 GTF2A1 0.47 5.68 0.3 2.9e-8 Obesity-related traits; LUSC cis rs877282 1.000 rs12219807 chr10:772870 A/C cg17470449 chr10:769945 NA 0.51 7.07 0.36 9.06e-12 Uric acid levels; LUSC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9549260 0.755 rs9549241 chr13:41210041 G/A cg21288729 chr13:41239152 FOXO1 0.62 9.74 0.47 6.97e-20 Red blood cell count; LUSC trans rs62103177 0.525 rs9949598 chr18:77753037 G/A cg05926928 chr17:57297772 GDPD1 -0.83 -9.51 -0.46 3.82e-19 Opioid sensitivity; LUSC cis rs11190604 1.000 rs3750629 chr10:102275727 A/G cg16342193 chr10:102329863 NA -0.37 -6.76 -0.35 6.13e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3820068 0.562 rs10927841 chr1:16045261 T/C cg17385448 chr1:15911702 AGMAT 0.36 5.86 0.31 1.13e-8 Systolic blood pressure; LUSC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg00999904 chr2:3704751 ALLC -0.43 -6.67 -0.34 1.06e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg04117972 chr1:227635322 NA 0.74 7.82 0.39 6.88e-14 Major depressive disorder; LUSC cis rs2073300 1.000 rs6036424 chr20:23459976 A/C cg09953122 chr20:23471693 CST8 0.65 6.65 0.34 1.18e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg21770322 chr7:97807741 LMTK2 0.56 9.93 0.48 1.51e-20 Breast cancer; LUSC cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.86 -0.54 2.57e-27 Chronic sinus infection; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg21724239 chr8:58056113 NA 0.8 8.55 0.42 4.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs559928 0.606 rs11605856 chr11:63925528 C/T cg24687543 chr11:63912206 MACROD1 0.48 5.84 0.3 1.26e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg04511125 chr2:88470314 THNSL2 -0.44 -6.45 -0.33 4.02e-10 Response to metformin (IC50); LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg22638593 chr5:131593259 PDLIM4 0.43 6.25 0.32 1.28e-9 Acylcarnitine levels; LUSC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg04414720 chr1:150670196 GOLPH3L -0.55 -8.97 -0.44 2.15e-17 Tonsillectomy; LUSC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg03806693 chr22:41940476 POLR3H 0.99 13.49 0.59 2e-33 Vitiligo; LUSC cis rs9346649 0.654 rs12527055 chr6:168492655 C/T cg02770688 chr6:168491649 NA 0.51 9.71 0.47 8.45e-20 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs7571561 0.625 rs6712295 chr2:213275113 A/G cg16329650 chr2:213403929 ERBB4 0.53 6.87 0.35 3.11e-11 Gestational age at birth in premature rupture of membrane-initiated deliveries (maternal effect); LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs7215564 0.908 rs34950888 chr17:78661779 T/G cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg06453172 chr10:134556979 INPP5A -0.53 -6.51 -0.34 2.81e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2315504 1.000 rs916926 chr17:39030283 T/A cg17985300 chr17:38952333 KRT28 -0.36 -7.37 -0.37 1.33e-12 Height; LUSC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg02475777 chr4:1388615 CRIPAK 0.43 6.39 0.33 5.68e-10 Obesity-related traits; LUSC cis rs2455601 0.638 rs2742478 chr11:8996099 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.43 -6.4 -0.33 5.2e-10 Schizophrenia; LUSC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.93 0.31 7.57e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.64 8.74 0.43 1.15e-16 Multiple sclerosis; LUSC cis rs2795502 1.000 rs2795508 chr10:43353555 G/T cg20628663 chr10:43360327 NA 0.73 10.96 0.51 4.51e-24 Blood protein levels; LUSC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg01416388 chr22:39784598 NA -0.44 -7.25 -0.37 3.01e-12 Intelligence (multi-trait analysis); LUSC cis rs765787 0.530 rs4775819 chr15:45525966 C/T cg24006582 chr15:45444508 DUOX1 -0.62 -9.45 -0.46 6.27e-19 Uric acid levels; LUSC cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg23711669 chr6:146136114 FBXO30 0.75 13.38 0.59 5.46e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs8114671 0.836 rs17404569 chr20:33674077 A/C cg07148914 chr20:33460835 GGT7 -0.46 -6.74 -0.35 7.17e-11 Height; LUSC cis rs4588572 0.643 rs7701154 chr5:77716621 G/A cg11547950 chr5:77652471 NA -0.52 -7.31 -0.37 2.05e-12 Triglycerides; LUSC trans rs1005277 0.602 rs1831315 chr10:38473353 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.27 -0.45 2.38e-18 Extrinsic epigenetic age acceleration; LUSC cis rs2204008 0.652 rs11513964 chr12:37998214 C/G cg26384229 chr12:38710491 ALG10B 0.92 15.76 0.65 3.19e-42 Bladder cancer; LUSC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg22834771 chr12:69754056 YEATS4 -0.55 -8.13 -0.41 8.34e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg04478727 chr12:58166393 METTL1;FAM119B -0.4 -5.71 -0.3 2.56e-8 Rheumatoid arthritis; LUSC cis rs2289583 0.544 rs1867153 chr15:75271229 C/T cg10253484 chr15:75165896 SCAMP2 0.43 5.75 0.3 2.07e-8 Systemic lupus erythematosus; LUSC cis rs3820068 0.608 rs10927831 chr1:16028373 T/G cg24675056 chr1:15929824 NA 0.4 6.58 0.34 1.87e-10 Systolic blood pressure; LUSC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.01 0.4 1.87e-14 Breast cancer; LUSC cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.98 0.31 5.61e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10823500 0.549 rs10999204 chr10:72007306 G/A cg02100629 chr10:71892760 AIFM2 -0.34 -5.92 -0.31 8.11e-9 Blood protein levels; LUSC cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.21 -0.45 3.77e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg09877947 chr5:131593287 PDLIM4 0.37 6.13 0.32 2.5e-9 Blood metabolite levels; LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg13047869 chr3:10149882 C3orf24 0.66 9.71 0.47 8.63e-20 Alzheimer's disease; LUSC trans rs41419946 1.000 rs12072131 chr1:165397025 G/A cg00234446 chr18:74208345 NA 0.69 6.26 0.32 1.21e-9 Gut microbiome composition (winter); LUSC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg10755058 chr3:40428713 ENTPD3 -0.33 -5.72 -0.3 2.36e-8 Renal cell carcinoma; LUSC cis rs9815354 1.000 rs73079316 chr3:41863859 G/A cg03022575 chr3:42003672 ULK4 0.64 7.04 0.36 1.1e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg06627628 chr2:24431161 ITSN2 0.86 13.15 0.58 4.26e-32 Asthma; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg20887711 chr4:1340912 KIAA1530 0.47 7.15 0.36 5.57e-12 Obesity-related traits; LUSC cis rs72781680 0.898 rs17762651 chr2:24115922 A/G cg20701182 chr2:24300061 SF3B14 0.55 5.83 0.3 1.32e-8 Lymphocyte counts; LUSC cis rs2073300 1.000 rs6137983 chr20:23469465 C/A cg09953122 chr20:23471693 CST8 -0.87 -6.99 -0.36 1.54e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg03579872 chr1:53393473 SCP2 -0.39 -5.74 -0.3 2.09e-8 Monocyte count; LUSC cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.27 0.49 1.09e-21 Schizophrenia; LUSC cis rs10752881 0.935 rs3935221 chr1:182969010 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 10.29 0.49 9.56e-22 Colorectal cancer; LUSC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg02423579 chr7:2872169 GNA12 -0.44 -6.35 -0.33 6.83e-10 Height; LUSC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg13647721 chr17:30228624 UTP6 0.64 6.43 0.33 4.46e-10 Hip circumference adjusted for BMI; LUSC cis rs9648716 0.515 rs38722 chr7:140695430 G/A cg23214464 chr7:140373596 ADCK2 0.74 6.33 0.33 8.04e-10 Type 2 diabetes; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg00260888 chr20:30865478 KIF3B 0.48 6.28 0.32 1.06e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2290416 0.892 rs61652493 chr8:144669164 G/A cg08017634 chr8:144659831 NAPRT1 0.72 6.12 0.32 2.59e-9 Attention deficit hyperactivity disorder; LUSC cis rs2274459 0.841 rs35698850 chr6:33700132 A/G cg06253072 chr6:33679850 C6orf125 0.5 6.0 0.31 5.28e-9 Obesity (extreme); LUSC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg01017244 chr2:74357527 NA 0.69 13.33 0.59 8.68e-33 Gestational age at birth (maternal effect); LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg07507251 chr3:52567010 NT5DC2 0.37 7.54 0.38 4.46e-13 Electroencephalogram traits; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg17291625 chr16:236080 NA 0.44 6.43 0.33 4.44e-10 Calcium levels; LUSC cis rs7481584 0.962 rs11024759 chr11:2982092 T/C cg08508325 chr11:3079039 CARS 0.3 5.84 0.3 1.27e-8 Calcium levels; LUSC cis rs892961 0.932 rs7207891 chr17:75413922 G/C cg05865280 chr17:75406074 SEPT9 0.46 9.54 0.46 3.07e-19 Airflow obstruction; LUSC cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg01579765 chr21:45077557 HSF2BP 0.54 11.3 0.53 2.7e-25 Mean corpuscular volume; LUSC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg04369109 chr6:150039330 LATS1 -0.56 -8.26 -0.41 3.39e-15 Lung cancer; LUSC cis rs13315871 1.000 rs12330157 chr3:58364562 C/T cg20936604 chr3:58311152 NA -0.63 -5.85 -0.31 1.15e-8 Cholesterol, total; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg03354898 chr7:1950403 MAD1L1 -0.34 -6.59 -0.34 1.73e-10 Bipolar disorder and schizophrenia; LUSC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg25427524 chr10:38739819 LOC399744 -0.71 -13.2 -0.59 2.65e-32 Extrinsic epigenetic age acceleration; LUSC cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.17 0.37 4.94e-12 Cognitive ability; LUSC trans rs3942852 0.806 rs11039515 chr11:48119474 A/G cg03929089 chr4:120376271 NA 0.5 6.18 0.32 1.87e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs11098499 0.909 rs35111518 chr4:120440682 A/G cg09307838 chr4:120376055 NA 0.74 10.31 0.49 7.79e-22 Corneal astigmatism; LUSC cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg06784218 chr1:46089804 CCDC17 -0.47 -9.14 -0.45 6.34e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg23093090 chr10:104574429 C10orf26 -0.39 -7.44 -0.38 8.66e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7617773 0.817 rs4131361 chr3:48328812 T/C cg11946769 chr3:48343235 NME6 0.86 13.87 0.6 7.36e-35 Coronary artery disease; LUSC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC cis rs782590 0.643 rs13032503 chr2:55739093 C/T cg03859395 chr2:55845619 SMEK2 -0.69 -10.4 -0.49 4.02e-22 Metabolic syndrome; LUSC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.5 0.42 6.22e-16 Height; LUSC cis rs7927592 0.546 rs599083 chr11:68192346 T/G cg01657329 chr11:68192670 LRP5 -0.47 -7.12 -0.36 6.78e-12 Total body bone mineral density; LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg00814883 chr7:100076585 TSC22D4 -0.73 -9.68 -0.47 1.05e-19 Platelet count; LUSC cis rs3925075 0.966 rs11645917 chr16:31359826 C/T cg02846316 chr16:31340340 ITGAM 0.33 6.04 0.31 4.19e-9 IgA nephropathy; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.53 0.34 2.48e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1322512 0.917 rs2758778 chr6:153007802 T/C cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs6574644 1.000 rs7153097 chr14:81772203 C/T cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg08045932 chr20:61659980 NA -0.58 -9.94 -0.48 1.47e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs5753618 0.539 rs737888 chr22:31611549 A/G cg22777020 chr22:31556080 RNF185 -0.47 -5.96 -0.31 6.29e-9 Colorectal cancer; LUSC cis rs9473147 0.516 rs6903331 chr6:47562915 A/G cg20196966 chr6:47445060 CD2AP 0.42 5.91 0.31 8.6e-9 Platelet distribution width;Mean platelet volume; LUSC trans rs61931739 0.500 rs11519398 chr12:34473553 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.36 0.64 1.21e-40 Morning vs. evening chronotype; LUSC cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -14.4 -0.62 6.88e-37 Chronic sinus infection; LUSC cis rs2109514 0.840 rs10228178 chr7:116132211 G/A cg12739419 chr7:116140593 CAV2 -0.27 -5.84 -0.3 1.26e-8 Prevalent atrial fibrillation; LUSC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg23281280 chr6:28129359 ZNF389 -0.44 -5.89 -0.31 9.47e-9 Depression; LUSC cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.56e-13 Motion sickness; LUSC cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.33 0.41 2.13e-15 High light scatter reticulocyte count; LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg08859206 chr1:53392774 SCP2 -0.55 -9.56 -0.46 2.58e-19 Monocyte count; LUSC cis rs12712073 0.845 rs1370353 chr2:100764824 G/C cg22139774 chr2:100720529 AFF3 -0.42 -7.25 -0.37 2.9e-12 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.81 0.51 1.43e-23 Bladder cancer; LUSC cis rs2439831 0.702 rs495175 chr15:43798684 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.15 0.52 9.43e-25 Lung cancer in ever smokers; LUSC cis rs7640424 0.649 rs6795280 chr3:107876232 T/C cg09227934 chr3:107805635 CD47 -0.36 -5.71 -0.3 2.51e-8 Body mass index; LUSC cis rs9467773 0.620 rs2451731 chr6:26624822 A/C cg05738196 chr6:26577821 NA 0.79 15.0 0.63 2.98e-39 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg04944784 chr2:26401820 FAM59B 0.78 11.16 0.52 8.66e-25 Gut microbiome composition (summer); LUSC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg05738196 chr6:26577821 NA -0.6 -7.21 -0.37 3.78e-12 Intelligence (multi-trait analysis); LUSC cis rs12579753 1.000 rs7975863 chr12:82227288 C/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs10779751 0.734 rs2791648 chr1:11132638 G/T cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC trans rs2243480 1.000 rs4145008 chr7:65647511 T/G cg10756647 chr7:56101905 PSPH -0.84 -8.42 -0.42 1.14e-15 Diabetic kidney disease; LUSC cis rs7191439 0.728 rs8043637 chr16:88781125 T/C cg02389323 chr16:88786976 FAM38A 1.14 11.21 0.52 5.67e-25 Plateletcrit; LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg05195085 chr7:157951403 PTPRN2 0.31 5.8 0.3 1.54e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs3764021 0.870 rs7307111 chr12:9877823 G/A cg20894963 chr12:9885564 CLECL1 0.35 7.1 0.36 7.55e-12 Type 1 diabetes; LUSC trans rs1908814 0.516 rs13281077 chr8:11794814 C/T cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.67e-16 Neuroticism; LUSC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg00339695 chr16:24857497 SLC5A11 0.59 8.98 0.44 2.04e-17 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg05025164 chr4:1340916 KIAA1530 0.43 6.43 0.33 4.39e-10 Obesity-related traits; LUSC trans rs1908814 0.516 rs4841641 chr8:11798227 G/A cg15556689 chr8:8085844 FLJ10661 0.57 8.53 0.42 5.11e-16 Neuroticism; LUSC cis rs7254114 0.578 rs73506605 chr19:11307564 G/A cg02815516 chr19:11306319 KANK2 -0.41 -8.63 -0.43 2.51e-16 Immature fraction of reticulocytes; LUSC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.3 -6.02 -0.31 4.61e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs911119 0.908 rs6048950 chr20:23603252 A/G cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg11905131 chr22:24372483 LOC391322 -0.61 -10.45 -0.5 2.74e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs61931739 0.817 rs10743841 chr12:34252870 T/C cg13010199 chr12:38710504 ALG10B 0.41 6.41 0.33 4.96e-10 Morning vs. evening chronotype; LUSC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg16434002 chr17:42200994 HDAC5 -0.45 -6.35 -0.33 6.83e-10 Total body bone mineral density; LUSC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg15664640 chr17:80829946 TBCD -0.5 -8.86 -0.44 4.83e-17 Breast cancer; LUSC cis rs11031096 0.711 rs10835723 chr11:4207566 G/C cg18678763 chr11:4115507 RRM1 -0.41 -5.77 -0.3 1.86e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg25072359 chr17:41440525 NA 0.64 9.34 0.45 1.45e-18 Menopause (age at onset); LUSC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.44 6.48 0.33 3.21e-10 Systemic lupus erythematosus; LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg22920501 chr2:26401640 FAM59B 0.83 12.04 0.55 5.72e-28 Gut microbiome composition (summer); LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg13395646 chr4:1353034 KIAA1530 -0.56 -8.25 -0.41 3.72e-15 Longevity; LUSC cis rs981844 1.000 rs72731674 chr4:154667447 C/A cg14289246 chr4:154710475 SFRP2 0.48 6.03 0.31 4.26e-9 Response to statins (LDL cholesterol change); LUSC cis rs7481584 0.624 rs80871 chr11:3049843 A/C cg25174290 chr11:3078921 CARS -0.41 -6.15 -0.32 2.19e-9 Calcium levels; LUSC trans rs1994135 0.669 rs11052746 chr12:33697473 A/C cg26384229 chr12:38710491 ALG10B -0.62 -8.6 -0.43 3.05e-16 Resting heart rate; LUSC cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs7089973 0.966 rs17721283 chr10:116644141 A/G cg23260525 chr10:116636907 FAM160B1 0.37 6.98 0.36 1.64e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg02254798 chr10:74856984 P4HA1 -0.53 -7.18 -0.37 4.6e-12 Hepatitis; LUSC cis rs3857536 0.776 rs1002764 chr6:66945760 C/A cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs8048589 0.615 rs12924889 chr16:12241768 A/G cg02910054 chr16:12241554 SNX29 0.52 6.44 0.33 4.24e-10 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg01475377 chr6:109611718 NA -0.43 -7.65 -0.39 2.14e-13 Reticulocyte fraction of red cells; LUSC cis rs7241530 0.636 rs4799010 chr18:75910590 T/A cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC cis rs921968 0.591 rs13421421 chr2:219519286 A/G cg02176678 chr2:219576539 TTLL4 0.61 11.05 0.52 2.17e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg25019033 chr10:957182 NA -0.5 -6.36 -0.33 6.72e-10 Eosinophil percentage of granulocytes; LUSC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg20916646 chr4:852691 GAK 0.44 6.87 0.35 3.09e-11 Sjögren's syndrome; LUSC cis rs4555082 0.874 rs78923231 chr14:105754033 C/T cg06808227 chr14:105710500 BRF1 -0.62 -8.77 -0.43 9.02e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs9929218 0.551 rs6499193 chr16:68727069 C/T cg01251360 chr16:68772225 CDH1 -0.25 -5.9 -0.31 8.86e-9 Colorectal cancer; LUSC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg20283391 chr11:68216788 NA -0.57 -8.1 -0.41 1.03e-14 Total body bone mineral density; LUSC trans rs1994135 0.669 rs2121831 chr12:33697674 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.68 0.47 1.06e-19 Resting heart rate; LUSC cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg06550200 chr5:1325588 CLPTM1L -0.65 -10.98 -0.51 3.75e-24 Lung cancer; LUSC cis rs17401966 1.000 rs4846208 chr1:10313839 T/C cg19773385 chr1:10388646 KIF1B -0.53 -8.3 -0.41 2.57e-15 Hepatocellular carcinoma; LUSC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg22467129 chr15:76604101 ETFA -0.46 -7.26 -0.37 2.73e-12 Blood metabolite levels; LUSC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10749792 chr7:56119218 PSPH;CCT6A -0.45 -6.96 -0.36 1.76e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11676348 0.774 rs57545959 chr2:219047718 A/G cg06547715 chr2:218990976 CXCR2 -0.32 -6.31 -0.33 8.77e-10 Ulcerative colitis; LUSC cis rs3772130 0.564 rs35178434 chr3:121595936 G/A cg11130432 chr3:121712080 ILDR1 0.36 5.71 0.3 2.47e-8 Cognitive performance; LUSC cis rs11971779 0.553 rs10085770 chr7:139100349 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg07701084 chr6:150067640 NUP43 0.51 7.26 0.37 2.75e-12 Lung cancer; LUSC cis rs10752881 1.000 rs10752887 chr1:182990834 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.94e-22 Colorectal cancer; LUSC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.8 -0.47 4.27e-20 Gut microbiome composition (summer); LUSC trans rs11098499 0.954 rs1480931 chr4:120395809 G/T cg25214090 chr10:38739885 LOC399744 0.56 8.42 0.42 1.09e-15 Corneal astigmatism; LUSC cis rs1113500 0.836 rs1122158 chr1:108588668 G/T cg06207961 chr1:108661230 NA 0.38 6.91 0.35 2.49e-11 Growth-regulated protein alpha levels; LUSC cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg23788917 chr6:8435910 SLC35B3 0.48 7.01 0.36 1.32e-11 Motion sickness; LUSC cis rs11098499 0.913 rs10010696 chr4:120164303 T/C cg24375607 chr4:120327624 NA 0.75 11.1 0.52 1.35e-24 Corneal astigmatism; LUSC cis rs701145 0.585 rs62276842 chr3:153784048 A/T cg17054900 chr3:154042577 DHX36 -0.55 -5.92 -0.31 8.07e-9 Coronary artery disease; LUSC cis rs354225 0.584 rs17046097 chr2:54888075 A/G cg01766943 chr2:54829624 SPTBN1 -0.4 -6.43 -0.33 4.47e-10 Schizophrenia; LUSC cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg17892150 chr10:133769511 PPP2R2D -0.65 -8.99 -0.44 1.89e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg19318889 chr4:1322082 MAEA 0.45 7.13 0.36 6.31e-12 Obesity-related traits; LUSC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.87 0.48 2.51e-20 Major depressive disorder; LUSC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs6952809 0.532 rs10227362 chr7:2456799 A/G cg23289794 chr7:2394357 EIF3B -0.71 -9.35 -0.46 1.3e-18 Multiple sclerosis; LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg25036284 chr2:26402008 FAM59B 0.77 10.94 0.51 5.08e-24 Gut microbiome composition (summer); LUSC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg21724239 chr8:58056113 NA 0.78 8.17 0.41 6.56e-15 Developmental language disorder (linguistic errors); LUSC cis rs76878669 0.538 rs1546358 chr11:66175261 G/C cg18002602 chr11:66138449 SLC29A2 0.46 8.08 0.4 1.17e-14 Educational attainment (years of education); LUSC cis rs7586879 0.558 rs6718510 chr2:25122323 A/C cg01884057 chr2:25150051 NA 0.48 11.3 0.53 2.75e-25 Body mass index; LUSC cis rs7927771 0.800 rs11039200 chr11:47379646 A/C cg20135002 chr11:47629003 NA -0.49 -7.36 -0.37 1.42e-12 Subjective well-being; LUSC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg24257776 chr3:47051546 LOC100129354 0.33 5.88 0.31 1e-8 Colorectal cancer; LUSC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg04111992 chr7:158790115 NA -0.44 -7.0 -0.36 1.42e-11 Facial morphology (factor 20); LUSC cis rs240764 0.817 rs240154 chr6:101065792 G/T cg09795085 chr6:101329169 ASCC3 0.42 6.14 0.32 2.3e-9 Neuroticism; LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg25767906 chr1:53392781 SCP2 0.52 9.44 0.46 6.73e-19 Monocyte count; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06642177 chr6:134496341 SGK1 0.36 6.61 0.34 1.51e-10 Triglycerides; LUSC cis rs4654899 0.895 rs10916866 chr1:21137768 C/A cg01072550 chr1:21505969 NA 0.46 6.85 0.35 3.5e-11 Superior frontal gyrus grey matter volume; LUSC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg06212747 chr3:49208901 KLHDC8B 0.58 8.04 0.4 1.55e-14 Menarche (age at onset); LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.43 -7.05 -0.36 1.02e-11 Longevity;Endometriosis; LUSC cis rs1372520 0.684 rs2619368 chr4:90729747 T/G cg01966878 chr4:90757139 SNCA -0.43 -6.22 -0.32 1.49e-9 Neuroticism; LUSC cis rs7712401 0.601 rs438196 chr5:122263063 T/G cg19077854 chr5:122220652 SNX24 0.41 8.93 0.44 2.84e-17 Mean platelet volume; LUSC cis rs11229555 0.645 rs36019763 chr11:58232283 G/T cg15696309 chr11:58395628 NA -0.71 -8.54 -0.42 4.81e-16 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2729354 0.729 rs2848634 chr11:57252328 G/A cg24343310 chr11:57249947 NA 0.44 8.52 0.42 5.43e-16 Blood protein levels; LUSC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg22532475 chr10:104410764 TRIM8 0.3 6.0 0.31 5.1e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7264396 0.676 rs6060727 chr20:34556000 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg13902645 chr11:5959945 NA -0.51 -6.85 -0.35 3.48e-11 DNA methylation (variation); LUSC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg07936489 chr17:37558343 FBXL20 0.73 10.16 0.49 2.53e-21 Glomerular filtration rate (creatinine); LUSC cis rs9818941 0.824 rs1123115 chr3:157813401 C/T cg08654915 chr3:157813417 NA 0.34 7.88 0.4 4.62e-14 Height; LUSC cis rs662735 0.515 rs507969 chr11:30830612 C/A cg14844989 chr11:31128820 NA 0.37 5.86 0.31 1.11e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg02018176 chr4:1364513 KIAA1530 -0.67 -11.82 -0.54 3.52e-27 Obesity-related traits; LUSC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg19539972 chr4:7069911 GRPEL1 0.72 9.06 0.44 1.13e-17 Monocyte percentage of white cells; LUSC trans rs7980799 0.649 rs11052732 chr12:33657801 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.21 -0.41 4.73e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs1322512 0.874 rs1105902 chr6:152961448 A/T cg27316956 chr6:152958899 SYNE1 -0.36 -6.22 -0.32 1.51e-9 Tonometry; LUSC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg16447950 chr5:562315 NA -0.54 -6.69 -0.34 9.26e-11 Obesity-related traits; LUSC trans rs61931739 0.500 rs11053251 chr12:34520743 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.19e-33 Morning vs. evening chronotype; LUSC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs8135665 0.600 rs6519096 chr22:38451389 C/T cg13116946 chr22:38479732 SLC16A8 0.42 6.26 0.32 1.17e-9 Advanced age-related macular degeneration;Age-related macular degeneration; LUSC cis rs2274273 0.905 rs2147961 chr14:55585381 T/C cg04306507 chr14:55594613 LGALS3 0.56 12.95 0.58 2.27e-31 Protein biomarker; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09213347 chr11:105948576 AASDHPPT;KBTBD3 -0.48 -7.28 -0.37 2.44e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6750047 0.771 rs1056836 chr2:38298203 C/G cg07380506 chr2:38303506 CYP1B1 -0.47 -6.46 -0.33 3.69e-10 Cutaneous malignant melanoma;Melanoma; LUSC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs16854884 0.802 rs6786460 chr3:143805895 A/G cg06585982 chr3:143692056 C3orf58 0.45 6.83 0.35 4.14e-11 Economic and political preferences (feminism/equality); LUSC cis rs1348850 0.793 rs12990917 chr2:178487259 T/G cg22681709 chr2:178499509 PDE11A -0.56 -10.64 -0.5 5.72e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs1325195 0.879 rs2793798 chr1:179094843 G/A cg11624085 chr17:8464688 MYH10 -0.44 -7.37 -0.37 1.32e-12 IgE grass sensitization; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25878452 chr7:6746558 ZNF12 0.77 6.05 0.31 3.98e-9 Cognitive performance; LUSC cis rs61931739 0.500 rs9705909 chr12:34576419 G/C cg06521331 chr12:34319734 NA -0.42 -6.47 -0.33 3.52e-10 Morning vs. evening chronotype; LUSC cis rs10254118 0.730 rs6961517 chr7:133130940 G/T cg10665199 chr7:133106180 EXOC4 0.52 7.02 0.36 1.23e-11 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.602 rs12209395 chr6:167463914 C/T cg07741184 chr6:167504864 NA 0.46 8.08 0.4 1.23e-14 Crohn's disease; LUSC cis rs4964805 0.954 rs4964812 chr12:104189615 A/G cg02344784 chr12:104178138 NT5DC3 0.45 7.15 0.36 5.34e-12 Attention deficit hyperactivity disorder; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg04568116 chr11:72353582 PDE2A 0.43 5.96 0.31 6.28e-9 Response to Homoharringtonine (cytotoxicity); LUSC trans rs61931739 0.817 rs10743842 chr12:34306859 C/T cg13010199 chr12:38710504 ALG10B 0.4 6.46 0.33 3.79e-10 Morning vs. evening chronotype; LUSC cis rs2742234 0.541 rs7073849 chr10:43740474 G/C cg15436174 chr10:43711423 RASGEF1A 0.43 7.0 0.36 1.43e-11 Hirschsprung disease; LUSC cis rs3916 0.955 rs2066938 chr12:121160615 A/G cg27246729 chr12:121163418 ACADS 0.5 7.38 0.37 1.27e-12 Urinary metabolites (H-NMR features); LUSC cis rs4363385 0.835 rs431242 chr1:153050414 G/A cg00922841 chr1:152955080 SPRR1A -0.46 -7.74 -0.39 1.23e-13 Inflammatory skin disease; LUSC cis rs3093024 0.595 rs4458654 chr6:167476068 A/C cg06454157 chr6:167490870 NA -0.29 -6.77 -0.35 5.66e-11 Rheumatoid arthritis; LUSC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg08798685 chr6:27730294 NA -0.63 -5.74 -0.3 2.08e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg10172584 chr19:19639581 YJEFN3 -0.46 -5.65 -0.3 3.42e-8 Bipolar disorder; LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg16405210 chr4:1374714 KIAA1530 0.53 8.31 0.41 2.35e-15 Obesity-related traits; LUSC trans rs3733585 0.673 rs4314284 chr4:9956096 C/T cg26043149 chr18:55253948 FECH -0.45 -6.85 -0.35 3.49e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg04756594 chr16:24857601 SLC5A11 0.46 6.86 0.35 3.34e-11 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs3087591 0.922 rs2953013 chr17:29496343 A/C cg24425628 chr17:29625626 OMG;NF1 -0.6 -8.69 -0.43 1.63e-16 Hip circumference; LUSC cis rs6835098 1.000 rs1054497 chr4:174089048 A/T cg08422745 chr4:174089978 GALNT7 0.79 13.19 0.59 2.85e-32 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs7561273 0.586 rs11892283 chr2:24317850 T/C cg20701182 chr2:24300061 SF3B14 0.51 6.55 0.34 2.19e-10 Quantitative traits; LUSC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg22508957 chr16:3507546 NAT15 0.43 6.21 0.32 1.57e-9 Body mass index (adult); LUSC cis rs1348850 0.526 rs6433672 chr2:178378175 G/T cg22681709 chr2:178499509 PDE11A -0.46 -6.79 -0.35 5.2e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11048434 0.761 rs1805723 chr12:9142297 T/C cg13575925 chr12:9217583 LOC144571 0.35 6.31 0.33 8.87e-10 Sjögren's syndrome; LUSC cis rs2970818 0.831 rs73037722 chr12:4573252 T/C cg11146114 chr12:4671731 NA -0.64 -6.12 -0.32 2.64e-9 Phosphorus levels; LUSC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg05623727 chr3:50126028 RBM5 -0.33 -6.13 -0.32 2.52e-9 Intelligence (multi-trait analysis); LUSC cis rs7246967 0.611 rs12978511 chr19:22819216 C/T cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg18876405 chr7:65276391 NA -0.54 -8.52 -0.42 5.73e-16 Aortic root size; LUSC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg05738196 chr6:26577821 NA 0.52 8.24 0.41 3.96e-15 Schizophrenia; LUSC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg17366294 chr4:99064904 C4orf37 0.55 9.59 0.46 2.1e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2742417 1.000 rs2673056 chr3:45737802 C/T cg09608765 chr3:45636137 LIMD1 -0.37 -7.2 -0.37 4.14e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2346177 1.000 rs2346177 chr2:46642249 A/G cg26688816 chr2:46740690 ATP6V1E2 0.55 8.81 0.43 6.86e-17 HDL cholesterol; LUSC cis rs9300255 0.739 rs6633 chr12:123745809 G/T cg13010344 chr12:123464640 ARL6IP4 0.51 6.25 0.32 1.25e-9 Neutrophil percentage of white cells; LUSC cis rs3815700 0.925 rs414496 chr19:33106761 A/G cg02997394 chr19:33096574 ANKRD27 0.58 6.64 0.34 1.3100000000000001e-10 Eosinophilic esophagitis; LUSC cis rs17826219 0.500 rs28452421 chr17:29083980 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Body mass index; LUSC cis rs7572644 0.679 rs4666012 chr2:28018293 A/G cg27432699 chr2:27873401 GPN1 0.56 7.27 0.37 2.54e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs708547 0.871 rs2687238 chr4:57880474 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 8.91 0.44 3.26e-17 Response to bleomycin (chromatid breaks); LUSC trans rs617791 0.530 rs7934543 chr11:65752508 G/T cg17712092 chr4:129076599 LARP1B -0.73 -10.28 -0.49 9.91e-22 Breast cancer; LUSC cis rs7980687 0.627 rs1727325 chr12:123698332 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Height;Educational attainment;Head circumference (infant); LUSC cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12618769 0.625 rs72821955 chr2:99159792 G/A cg10123293 chr2:99228465 UNC50 0.47 7.36 0.37 1.45e-12 Bipolar disorder; LUSC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg17344932 chr17:38183730 MED24;SNORD124 0.37 6.03 0.31 4.26e-9 Self-reported allergy; LUSC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg20607798 chr8:58055168 NA 0.54 6.22 0.32 1.5e-9 Developmental language disorder (linguistic errors); LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg11645453 chr3:52864694 ITIH4 0.32 7.46 0.38 7.55e-13 Electroencephalogram traits; LUSC cis rs12210905 1.000 rs76889265 chr6:27008835 T/C cg23155468 chr6:27110703 HIST1H2BK -0.7 -5.88 -0.31 1.02e-8 Hip circumference adjusted for BMI; LUSC cis rs10761482 0.861 rs10761489 chr10:62108604 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.1 -0.36 7.67e-12 Schizophrenia; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg07362569 chr17:61921086 SMARCD2 0.38 7.98 0.4 2.33e-14 Prudent dietary pattern; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26323130 chr2:149632683 KIF5C 0.48 7.26 0.37 2.69e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.11 -0.36 7.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg00012203 chr2:219082015 ARPC2 -0.7 -11.58 -0.54 2.78e-26 Colorectal cancer; LUSC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg18827107 chr12:86230957 RASSF9 -0.47 -6.99 -0.36 1.55e-11 Major depressive disorder; LUSC cis rs4808199 0.948 rs7259434 chr19:19428805 A/T cg03709012 chr19:19516395 GATAD2A 0.95 11.68 0.54 1.14e-26 Nonalcoholic fatty liver disease; LUSC cis rs7173743 0.816 rs11639335 chr15:79142307 A/G cg00540400 chr15:79124168 NA -0.35 -5.87 -0.31 1.03e-8 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18332849 chr19:45682064 BLOC1S3;TRAPPC6A -0.41 -6.09 -0.32 3.08e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7193541 0.965 rs4402594 chr16:74701360 C/T cg01733217 chr16:74700730 RFWD3 0.87 15.35 0.64 1.32e-40 Multiple myeloma; LUSC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg12927641 chr6:109611667 NA -0.36 -6.03 -0.31 4.39e-9 Reticulocyte fraction of red cells; LUSC cis rs4474465 0.850 rs10793323 chr11:78244170 C/T cg27205649 chr11:78285834 NARS2 0.48 5.95 0.31 6.88e-9 Alzheimer's disease (survival time); LUSC cis rs7520050 0.778 rs12404197 chr1:46232420 G/A cg06784218 chr1:46089804 CCDC17 -0.31 -6.08 -0.32 3.36e-9 Red blood cell count;Reticulocyte count; LUSC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg06915202 chr7:98029285 BAIAP2L1 -0.29 -5.71 -0.3 2.51e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs6733011 0.559 rs6711022 chr2:99449536 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.4 -5.77 -0.3 1.82e-8 Bipolar disorder; LUSC cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.94 -17.38 -0.69 1.15e-48 Chronic sinus infection; LUSC cis rs10207060 0.500 rs7600350 chr2:240716225 T/C cg20333904 chr2:240724165 NA -0.35 -6.08 -0.32 3.26e-9 Obesity-related traits; LUSC cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.51e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.12e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1949733 0.666 rs3103070 chr4:8508825 A/G cg11789530 chr4:8429930 ACOX3 -0.54 -7.98 -0.4 2.36e-14 Response to antineoplastic agents; LUSC trans rs853679 0.607 rs201002 chr6:27808192 A/G cg06606381 chr12:133084897 FBRSL1 -0.73 -7.87 -0.4 5.09e-14 Depression; LUSC cis rs8141529 0.719 rs6005916 chr22:29233342 T/C cg02153584 chr22:29168773 CCDC117 0.64 10.32 0.49 7.61e-22 Lymphocyte counts; LUSC cis rs9325144 0.560 rs11183189 chr12:38683770 T/A cg13010199 chr12:38710504 ALG10B 0.46 6.81 0.35 4.61e-11 Morning vs. evening chronotype; LUSC trans rs62238980 0.614 rs117517889 chr22:32469452 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg01943577 chr7:158741284 NA -0.4 -5.79 -0.3 1.62e-8 Height; LUSC cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg23711669 chr6:146136114 FBXO30 -0.87 -15.94 -0.66 5.95e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.87 0.35 3.08e-11 Endometrial cancer; LUSC cis rs62400317 0.859 rs11965706 chr6:45141441 T/A cg20913747 chr6:44695427 NA -0.47 -7.55 -0.38 4.28e-13 Total body bone mineral density; LUSC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -9.7 -0.47 9.34e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg11266682 chr4:10021025 SLC2A9 -0.48 -8.51 -0.42 5.89e-16 Bone mineral density; LUSC cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg06784218 chr1:46089804 CCDC17 0.58 11.44 0.53 8.22e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.27 0.45 2.34e-18 Prudent dietary pattern; LUSC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg03517284 chr6:25882590 NA 0.38 6.63 0.34 1.35e-10 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11966583 chr1:166845478 TADA1 0.47 6.57 0.34 1.97e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs478304 0.934 rs570954 chr11:65498261 A/G cg05805236 chr11:65401703 PCNXL3 0.41 6.89 0.35 2.78e-11 Acne (severe); LUSC cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg19628046 chr18:33552617 C18orf21 0.52 6.34 0.33 7.36e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg26338869 chr17:61819248 STRADA 0.42 6.18 0.32 1.86e-9 Prudent dietary pattern; LUSC cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg07395648 chr5:131743802 NA -0.42 -6.41 -0.33 5.06e-10 Breast cancer; LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg22963979 chr7:1858916 MAD1L1 -0.63 -10.22 -0.49 1.68e-21 Bipolar disorder and schizophrenia; LUSC cis rs9929218 0.748 rs34592833 chr16:68739125 G/A cg02972257 chr16:68554789 NA 0.45 5.79 0.3 1.64e-8 Colorectal cancer; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg13047869 chr3:10149882 C3orf24 0.56 8.01 0.4 1.93e-14 Alzheimer's disease; LUSC cis rs6547741 1.000 rs7604798 chr2:27824940 T/C cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 2.94e-39 Oral cavity cancer; LUSC cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg24558204 chr6:135376177 HBS1L 0.68 10.52 0.5 1.57e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg06697600 chr4:7070879 GRPEL1 0.49 6.86 0.35 3.27e-11 Monocyte percentage of white cells; LUSC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg19622623 chr12:86230825 RASSF9 -0.44 -6.09 -0.32 3.18e-9 Major depressive disorder; LUSC cis rs12893668 0.543 rs12147645 chr14:104100208 T/A cg08213375 chr14:104286397 PPP1R13B 0.42 7.26 0.37 2.8e-12 Reticulocyte count; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg27094323 chr7:1216898 NA -0.37 -6.55 -0.34 2.21e-10 Longevity;Endometriosis; LUSC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg16339924 chr4:17578868 LAP3 0.55 8.45 0.42 8.91e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7312933 0.533 rs3747557 chr12:42717961 G/T cg01256987 chr12:42539512 GXYLT1 0.35 6.4 0.33 5.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.17 -0.32 1.96e-9 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg00149659 chr3:10157352 C3orf10 0.91 12.44 0.56 1.89e-29 Alzheimer's disease; LUSC cis rs8092503 0.953 rs2052326 chr18:52489444 G/C cg12377874 chr18:52495404 RAB27B -0.34 -6.29 -0.33 1.01e-9 Childhood body mass index; LUSC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg14343924 chr8:8086146 FLJ10661 0.44 5.82 0.3 1.35e-8 Neuroticism; LUSC trans rs961253 0.556 rs1160794 chr20:6330480 G/C cg21095983 chr6:86352623 SYNCRIP 0.45 6.78 0.35 5.62e-11 Colorectal cancer; LUSC cis rs12594711 1 rs12594711 chr15:78793921 C/T cg18825076 chr15:78729989 IREB2 -0.43 -6.82 -0.35 4.31e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg05872129 chr22:39784769 NA -0.61 -11.71 -0.54 9.43e-27 Intelligence (multi-trait analysis); LUSC cis rs1451375 0.652 rs7803788 chr7:50625898 A/G cg18232548 chr7:50535776 DDC -0.49 -6.79 -0.35 5.19e-11 Malaria; LUSC trans rs1325195 0.537 rs61821690 chr1:179188006 C/T cg11624085 chr17:8464688 MYH10 0.43 6.38 0.33 5.94e-10 IgE grass sensitization; LUSC cis rs965469 0.895 rs6037592 chr20:3392950 T/G cg25506879 chr20:3388711 C20orf194 -0.53 -5.76 -0.3 1.94e-8 IFN-related cytopenia; LUSC cis rs7512552 0.839 rs486275 chr1:150282784 G/A cg15654264 chr1:150340011 RPRD2 -0.65 -11.03 -0.52 2.44e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs6951245 0.572 rs73265918 chr7:1056809 C/A cg24642844 chr7:1081250 C7orf50 -0.62 -6.14 -0.32 2.41e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18099408 chr3:52552593 STAB1 -0.36 -6.29 -0.33 9.76e-10 Electroencephalogram traits; LUSC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg23283495 chr1:209979779 IRF6 0.67 7.92 0.4 3.5e-14 Cleft lip with or without cleft palate; LUSC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg14019146 chr3:50243930 SLC38A3 -0.37 -8.48 -0.42 7.13e-16 Body mass index; LUSC cis rs2046867 0.862 rs62252360 chr3:72838551 C/T cg25664220 chr3:72788482 NA -0.69 -11.54 -0.53 3.7e-26 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg27398817 chr8:82754497 SNX16 -0.51 -6.79 -0.35 5.01e-11 Diastolic blood pressure; LUSC cis rs4845459 0.967 rs1581803 chr1:152592281 A/C cg08895932 chr1:152778580 LCE1C 0.36 6.28 0.32 1.08e-9 Psoriasis; LUSC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg00310523 chr12:86230176 RASSF9 0.43 7.73 0.39 1.24e-13 Major depressive disorder; LUSC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg22166914 chr1:53195759 ZYG11B 0.69 11.84 0.54 2.93e-27 Monocyte count; LUSC cis rs3820928 1.000 rs7579961 chr2:227776976 T/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.98 -0.4 2.36e-14 Pulmonary function; LUSC cis rs9303401 0.580 rs12603808 chr17:56578508 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.81 11.85 0.54 2.86e-27 Cognitive test performance; LUSC cis rs17661538 0.542 rs12779075 chr10:18427010 G/A cg03634479 chr10:18430412 CACNB2 0.61 5.94 0.31 7.32e-9 Response to antipsychotic treatment; LUSC cis rs10905065 1.000 rs10905065 chr10:5769827 C/T cg11519256 chr10:5708881 ASB13 0.42 6.31 0.33 9.1e-10 Menopause (age at onset); LUSC trans rs1375144 0.676 rs12711825 chr2:116168072 G/T cg02581963 chr10:102133317 C10orf75 -0.38 -5.99 -0.31 5.44e-9 Bipolar disorder; LUSC cis rs477692 1.000 rs553371 chr10:131413676 T/C cg26102564 chr10:131424627 MGMT 0.4 6.2 0.32 1.62e-9 Response to temozolomide; LUSC cis rs2717559 0.542 rs2717590 chr8:143900712 A/G cg17252645 chr8:143867129 LY6D -0.55 -10.25 -0.49 1.31e-21 Urinary tract infection frequency; LUSC cis rs1055129 0.560 rs3682 chr17:73942150 A/G cg19302996 chr17:73780495 UNK -0.51 -7.32 -0.37 1.83e-12 White matter hyperintensity burden; LUSC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg10802521 chr3:52805072 NEK4 -0.54 -7.13 -0.36 6.22e-12 Bipolar disorder; LUSC trans rs6841433 0.615 rs79776742 chr4:115471351 A/G cg01865118 chr8:29204221 DUSP4 -0.51 -5.97 -0.31 5.93e-9 Hemoglobin concentration; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.18 -0.32 1.89e-9 Developmental language disorder (linguistic errors); LUSC trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg20587970 chr11:113659929 NA -1.35 -19.01 -0.72 3.8e-55 Hip circumference adjusted for BMI; LUSC cis rs2567992 0.821 rs1169721 chr12:121641509 A/G cg19357999 chr12:121661762 P2RX4 0.49 6.29 0.33 1.02e-9 Left ventricular obstructive tract defect (inherited effect); LUSC trans rs2243480 0.803 rs35480979 chr7:65357084 A/G cg10756647 chr7:56101905 PSPH 0.87 8.39 0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.69 0.34 9.48e-11 Schizophrenia; LUSC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.46e-11 Tonsillectomy; LUSC cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg09085632 chr11:111637200 PPP2R1B 1.16 18.4 0.71 1.09e-52 Primary sclerosing cholangitis; LUSC cis rs6681460 0.966 rs2025595 chr1:67152499 G/A cg02459107 chr1:67143332 SGIP1 0.5 9.17 0.45 5.14e-18 Presence of antiphospholipid antibodies; LUSC cis rs9467773 0.620 rs2504565 chr6:26656890 G/A cg05738196 chr6:26577821 NA 0.78 14.77 0.63 2.49e-38 Intelligence (multi-trait analysis); LUSC cis rs11711311 1.000 rs9830975 chr3:113486019 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.41 -5.65 -0.3 3.48e-8 IgG glycosylation; LUSC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg11764359 chr7:65958608 NA 0.61 9.19 0.45 4.28e-18 Aortic root size; LUSC cis rs763121 0.819 rs5757133 chr22:38947835 A/G cg14440974 chr22:39074834 NA 0.37 6.22 0.32 1.53e-9 Menopause (age at onset); LUSC cis rs56399783 0.901 rs11761804 chr7:2792524 C/T cg19731401 chr7:2775893 GNA12 0.74 8.48 0.42 7.58e-16 Childhood ear infection; LUSC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 10.0 0.48 8.85e-21 Personality dimensions; LUSC cis rs9359856 0.564 rs10484885 chr6:90395016 A/G cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.53 -0.42 5.15e-16 Bipolar disorder; LUSC trans rs9561329 0.528 rs1323986 chr13:93999772 A/G cg25981597 chr2:197504344 CCDC150 0.47 6.2 0.32 1.68e-9 Neuroticism (age interaction); LUSC cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg25258033 chr6:167368657 RNASET2 0.43 6.91 0.35 2.52e-11 Crohn's disease; LUSC cis rs2688608 0.592 rs10762563 chr10:75524802 C/A cg17411546 chr10:75410026 SYNPO2L -0.51 -7.82 -0.39 7.12e-14 Inflammatory bowel disease; LUSC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg11764359 chr7:65958608 NA -0.79 -12.98 -0.58 1.74e-31 Aortic root size; LUSC cis rs72781680 0.848 rs6754694 chr2:24155448 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.13 0.48 3.27e-21 Lymphocyte counts; LUSC cis rs7106204 0.748 rs12273426 chr11:24212058 T/C ch.11.24196551F chr11:24239977 NA 1.11 12.47 0.56 1.48e-29 Response to Homoharringtonine (cytotoxicity); LUSC cis rs17270561 0.609 rs7754296 chr6:25744878 A/G cg17691542 chr6:26056736 HIST1H1C 0.53 7.44 0.38 8.62e-13 Iron status biomarkers; LUSC cis rs2658782 0.789 rs2605580 chr11:93147054 C/T cg15737290 chr11:93063684 CCDC67 0.64 7.97 0.4 2.49e-14 Pulmonary function decline; LUSC trans rs9291683 0.632 rs12508991 chr4:10041104 C/T cg26043149 chr18:55253948 FECH 0.5 7.33 0.37 1.76e-12 Bone mineral density; LUSC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg04539111 chr16:67997858 SLC12A4 -0.46 -6.22 -0.32 1.52e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg04865166 chr7:105162814 PUS7 0.52 5.67 0.3 3.03e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.38 -6.23 -0.32 1.39e-9 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg24675056 chr1:15929824 NA 0.49 8.45 0.42 8.94e-16 Systolic blood pressure; LUSC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg08499158 chr17:42289980 UBTF -0.51 -8.28 -0.41 3.03e-15 Total body bone mineral density; LUSC cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg12011299 chr4:100065546 ADH4 0.69 11.94 0.55 1.37e-27 Alcohol dependence; LUSC cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg23711669 chr6:146136114 FBXO30 0.9 16.97 0.68 5.35e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg17063962 chr7:91808500 NA -0.56 -8.65 -0.43 2.28e-16 Breast cancer; LUSC cis rs4555082 0.789 rs2816649 chr14:105708326 A/G cg10792982 chr14:105748885 BRF1 0.49 8.96 0.44 2.38e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.52 0.78 5.67e-69 Height; LUSC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs10504073 0.669 rs11779189 chr8:50030592 C/G cg00325661 chr8:49890786 NA -0.56 -9.58 -0.46 2.38e-19 Blood metabolite ratios; LUSC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC trans rs3942852 0.868 rs58407618 chr11:48104167 T/G cg03929089 chr4:120376271 NA -0.52 -5.95 -0.31 6.89e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg19266014 chr7:2183958 MAD1L1 -0.35 -5.88 -0.31 1e-8 Bipolar disorder and schizophrenia; LUSC cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg04317338 chr11:64019027 PLCB3 0.66 7.34 0.37 1.6e-12 Mean platelet volume; LUSC cis rs950776 0.518 rs4243083 chr15:78833830 C/G cg22563815 chr15:78856949 CHRNA5 -0.26 -6.22 -0.32 1.52e-9 Sudden cardiac arrest; LUSC cis rs9807989 0.507 rs10208196 chr2:102996345 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.11 0.36 7.27e-12 Asthma; LUSC cis rs12579753 0.597 rs2244802 chr12:82153749 C/G cg21231944 chr12:82153410 PPFIA2 0.35 5.84 0.3 1.21e-8 Resting heart rate; LUSC cis rs17540621 1.000 rs116079162 chr2:47230808 C/T cg23978866 chr2:47230407 TTC7A -0.97 -6.63 -0.34 1.38e-10 Response to statin therapy; LUSC cis rs7103648 0.966 rs874896 chr11:47418953 C/G cg20307385 chr11:47447363 PSMC3 0.99 19.34 0.73 1.98e-56 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg11764359 chr7:65958608 NA -0.78 -13.02 -0.58 1.25e-31 Aortic root size; LUSC cis rs1003719 0.751 rs7280371 chr21:38450008 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.43 0.53 9.68e-26 Eye color traits; LUSC trans rs61931739 0.926 rs13377754 chr12:34051765 T/C cg13010199 chr12:38710504 ALG10B -0.4 -6.02 -0.31 4.52e-9 Morning vs. evening chronotype; LUSC cis rs1595825 0.891 rs77706948 chr2:198608441 T/G cg10547527 chr2:198650123 BOLL -0.49 -5.72 -0.3 2.4e-8 Ulcerative colitis; LUSC trans rs9929218 0.953 rs34909703 chr16:68740097 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -13.16 -0.58 3.69e-32 Colorectal cancer; LUSC cis rs6977660 0.714 rs4721824 chr7:19785898 A/G cg07541023 chr7:19748670 TWISTNB 0.67 6.71 0.34 8.19e-11 Thyroid stimulating hormone; LUSC cis rs4253772 0.744 rs1134224 chr22:46633371 A/T cg24881330 chr22:46731750 TRMU 0.67 8.01 0.4 1.94e-14 LDL cholesterol;Cholesterol, total; LUSC cis rs713587 0.525 rs11675457 chr2:25079770 C/T cg04586622 chr2:25135609 ADCY3 0.37 7.8 0.39 7.84e-14 Body mass index in non-asthmatics; LUSC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg14582100 chr15:45693742 SPATA5L1 0.59 10.71 0.51 3.25e-23 Homoarginine levels; LUSC cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg13010199 chr12:38710504 ALG10B 0.66 10.0 0.48 9.42e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg23630131 chr7:65973040 NA -0.2 -5.67 -0.3 3.05e-8 Aortic root size; LUSC cis rs6942756 1.000 rs66538149 chr7:128974061 G/A cg02491457 chr7:128862824 NA -0.47 -6.31 -0.33 9.1e-10 White matter hyperintensity burden; LUSC trans rs9329221 0.527 rs34308302 chr8:10332022 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -7.37 -0.37 1.38e-12 Neuroticism; LUSC cis rs11608355 1.000 rs11066523 chr12:109851899 A/G cg19025524 chr12:109796872 NA 0.39 6.22 0.32 1.53e-9 Neuroticism; LUSC cis rs977987 0.866 rs17696831 chr16:75493298 C/G cg04384234 chr16:75411784 CFDP1 -0.48 -7.87 -0.4 5.05e-14 Dupuytren's disease; LUSC cis rs7605827 0.681 rs63106161 chr2:15537726 T/C cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs9815354 0.767 rs73073342 chr3:41839455 A/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.05 0.64 1.96e-39 Platelet count; LUSC cis rs7786808 0.608 rs6978352 chr7:158209802 T/C cg01191920 chr7:158217561 PTPRN2 0.43 8.45 0.42 9.08e-16 Obesity-related traits; LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.35 0.76 2.22e-64 Prudent dietary pattern; LUSC cis rs4654899 0.827 rs12564330 chr1:21207495 A/C cg01072550 chr1:21505969 NA 0.5 7.64 0.39 2.27e-13 Superior frontal gyrus grey matter volume; LUSC cis rs62103177 0.565 rs473119 chr18:77849459 T/G cg02751453 chr18:77725136 HSBP1L1 0.41 5.65 0.3 3.41e-8 Opioid sensitivity; LUSC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg06454157 chr6:167490870 NA -0.25 -6.03 -0.31 4.28e-9 Crohn's disease; LUSC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.99 -0.31 5.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs780094 0.500 rs74175068 chr2:27833502 T/C cg27432699 chr2:27873401 GPN1 0.41 5.87 0.31 1.07e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg27286337 chr10:134555280 INPP5A 0.92 11.91 0.55 1.72e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10876993 0.890 rs1678516 chr12:58047458 G/A cg15848620 chr12:58087721 OS9 -0.52 -7.41 -0.38 1.02e-12 Celiac disease or Rheumatoid arthritis; LUSC cis rs9326248 1.000 rs7946257 chr11:117053165 A/G cg15534755 chr11:117069859 TAGLN 0.35 5.99 0.31 5.53e-9 Blood protein levels; LUSC cis rs2227564 0.597 rs12256103 chr10:75545251 A/G cg23231163 chr10:75533350 FUT11 -0.47 -6.93 -0.35 2.11e-11 Crohn's disease;Inflammatory bowel disease; LUSC trans rs4942242 0.617 rs9590778 chr13:44199007 C/G cg19169023 chr15:41853346 TYRO3 -0.61 -9.17 -0.45 4.87e-18 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7177699 0.557 rs10083697 chr15:79124039 G/A cg00540400 chr15:79124168 NA -0.47 -8.15 -0.41 7.33e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9322817 0.691 rs2499664 chr6:105301484 C/G cg02098413 chr6:105308735 HACE1 0.27 5.68 0.3 2.95e-8 Thyroid stimulating hormone; LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.54 -8.13 -0.41 8.35e-15 Lymphocyte counts; LUSC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg18252515 chr7:66147081 NA -0.4 -5.73 -0.3 2.2e-8 Aortic root size; LUSC cis rs9815354 0.680 rs17218936 chr3:42019392 C/T cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg24812749 chr6:127587940 RNF146 0.91 13.51 0.59 1.7e-33 Breast cancer; LUSC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg25019033 chr10:957182 NA -0.54 -6.9 -0.35 2.65e-11 Eosinophil percentage of granulocytes; LUSC cis rs11190604 1.000 rs2495741 chr10:102331795 A/G cg16342193 chr10:102329863 NA -0.36 -6.76 -0.35 6.34e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11098499 0.954 rs7681544 chr4:120411255 T/C cg09307838 chr4:120376055 NA 0.79 11.8 0.54 4.37e-27 Corneal astigmatism; LUSC trans rs2229238 0.911 rs7551873 chr1:154505857 A/G cg25273160 chr11:56955011 LRRC55 -0.31 -6.0 -0.31 5.19e-9 Coronary heart disease; LUSC cis rs11158026 0.790 rs1107960 chr14:55384340 T/A cg04306507 chr14:55594613 LGALS3 0.32 6.09 0.32 3.15e-9 Parkinson's disease; LUSC cis rs6964587 0.967 rs4626516 chr7:91807153 G/C cg17063962 chr7:91808500 NA 0.57 8.82 0.43 6.68e-17 Breast cancer; LUSC cis rs2404602 0.692 rs66866130 chr15:77128574 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.76 -0.39 1.07e-13 Blood metabolite levels; LUSC cis rs4727027 0.704 rs12535154 chr7:148895304 G/A cg23583168 chr7:148888333 NA -0.9 -17.81 -0.7 2.42e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7107174 1.000 rs10899481 chr11:78058721 A/T cg02023728 chr11:77925099 USP35 -0.43 -6.53 -0.34 2.41e-10 Testicular germ cell tumor; LUSC cis rs265548 0.510 rs28415068 chr19:17910582 T/A cg16744531 chr19:17905626 B3GNT3 0.46 6.8 0.35 4.74e-11 Tumor biomarkers; LUSC trans rs853679 0.607 rs34661125 chr6:28281894 G/A cg01620082 chr3:125678407 NA -0.79 -7.53 -0.38 4.89e-13 Depression; LUSC cis rs2029213 0.523 rs2035450 chr3:53269317 C/T cg16894138 chr3:53270350 TKT 0.32 7.11 0.36 7.18e-12 Heart rate; LUSC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11890956 chr21:40555474 PSMG1 1.01 18.62 0.71 1.43e-53 Cognitive function; LUSC cis rs6840360 1.000 rs6838966 chr4:152603475 C/T cg22705602 chr4:152727874 NA -0.27 -5.9 -0.31 8.83e-9 Intelligence (multi-trait analysis); LUSC trans rs4714291 0.698 rs9296321 chr6:40118352 C/T cg02267698 chr19:7991119 CTXN1 -0.52 -7.9 -0.4 4.01e-14 Strep throat; LUSC cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg21427119 chr20:30132790 HM13 -0.36 -5.67 -0.3 3.14e-8 Mean corpuscular hemoglobin; LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg12016809 chr21:47604291 C21orf56 0.47 6.89 0.35 2.79e-11 Testicular germ cell tumor; LUSC cis rs593982 0.925 rs585272 chr11:65505289 A/G cg08755490 chr11:65554678 OVOL1 1.41 17.72 0.7 5.44e-50 Atopic dermatitis; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg09177884 chr7:1199841 ZFAND2A -0.53 -7.18 -0.37 4.58e-12 Longevity;Endometriosis; LUSC cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.74e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2274273 0.840 rs10142448 chr14:55838108 G/T cg04306507 chr14:55594613 LGALS3 -0.54 -11.71 -0.54 8.73e-27 Protein biomarker; LUSC cis rs9399137 0.507 rs11758774 chr6:135383789 T/G cg24558204 chr6:135376177 HBS1L 0.69 10.73 0.51 2.87e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.42 -0.5 3.32e-22 Alzheimer's disease; LUSC trans rs61931739 0.517 rs12367881 chr12:34175508 T/C cg13010199 chr12:38710504 ALG10B 0.55 8.49 0.42 6.68e-16 Morning vs. evening chronotype; LUSC cis rs9430161 0.611 rs12081181 chr1:11034165 T/G cg27631724 chr1:11040367 C1orf127 0.52 9.04 0.44 1.31e-17 Ewing sarcoma; LUSC cis rs7106204 0.514 rs11027789 chr11:24260906 T/C ch.11.24196551F chr11:24239977 NA 0.82 8.33 0.41 2.17e-15 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.65 -0.69 9.78e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg19508488 chr2:152266495 RIF1 0.54 7.73 0.39 1.23e-13 Lung cancer; LUSC cis rs7584330 0.780 rs937395 chr2:238378749 T/C cg14458575 chr2:238380390 NA 0.68 11.78 0.54 4.99e-27 Prostate cancer; LUSC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg01448562 chr3:133502909 NA -0.67 -10.96 -0.51 4.51e-24 Iron status biomarkers; LUSC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg14668632 chr7:2872130 GNA12 -0.47 -7.43 -0.38 9.26e-13 Height; LUSC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs2108225 0.714 rs929393 chr7:107437048 C/T cg18560240 chr7:107437656 SLC26A3 -0.44 -6.88 -0.35 2.88e-11 Ulcerative colitis; LUSC trans rs11992162 0.933 rs10108075 chr8:11832079 A/G cg08975724 chr8:8085496 FLJ10661 0.51 7.23 0.37 3.22e-12 Monocyte count; LUSC cis rs4953404 0.613 rs930853 chr2:46898849 A/G cg09399716 chr2:46890238 NA -0.3 -6.62 -0.34 1.42e-10 Pulse pressure (alcohol consumption interaction); LUSC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg24675056 chr1:15929824 NA 0.44 7.65 0.39 2.11e-13 Systolic blood pressure; LUSC cis rs4808199 0.947 rs751858 chr19:19602821 G/C cg03709012 chr19:19516395 GATAD2A 1.08 14.54 0.62 1.95e-37 Nonalcoholic fatty liver disease; LUSC cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg05283184 chr6:79620031 NA -0.57 -12.03 -0.55 6.25e-28 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs10872427 chr6:135353452 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.24 0.45 2.88e-18 Red blood cell count; LUSC cis rs7726839 0.574 rs72707007 chr5:661856 T/C cg09021430 chr5:549028 NA -0.53 -7.24 -0.37 3.18e-12 Obesity-related traits; LUSC cis rs1595825 0.891 rs73058876 chr2:198895022 A/G cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg05347473 chr6:146136440 FBXO30 0.57 10.03 0.48 7.41e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs17270561 0.609 rs1185976 chr6:25822363 A/G cg17691542 chr6:26056736 HIST1H1C -0.48 -6.96 -0.36 1.86e-11 Iron status biomarkers; LUSC cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg26647111 chr11:31128758 NA -0.42 -6.03 -0.31 4.44e-9 Red blood cell count; LUSC cis rs60154123 0.772 rs845452 chr1:210417861 C/T cg22029157 chr1:209979665 IRF6 0.65 6.49 0.33 3.08e-10 Coronary artery disease; LUSC cis rs28829049 0.566 rs59681755 chr1:19528985 G/A cg13387374 chr1:19411106 UBR4 0.46 6.37 0.33 6.31e-10 QRS duration in Tripanosoma cruzi seropositivity; LUSC trans rs2832077 0.883 rs11702413 chr21:30188395 A/C cg14791747 chr16:20752902 THUMPD1 0.73 9.55 0.46 2.84e-19 Cognitive test performance; LUSC cis rs7590368 0.715 rs7587453 chr2:10961390 A/G cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg26513180 chr16:89883248 FANCA -0.53 -7.82 -0.39 7.21e-14 Vitiligo; LUSC cis rs9831754 0.654 rs9837024 chr3:78451637 C/T cg06138941 chr3:78371609 NA 0.55 7.18 0.37 4.47e-12 Calcium levels; LUSC cis rs11971779 1.000 rs75919582 chr7:139054919 G/A cg07862535 chr7:139043722 LUC7L2 0.73 8.06 0.4 1.39e-14 Diisocyanate-induced asthma; LUSC cis rs67311347 0.713 rs73073505 chr3:40310693 C/T cg09455208 chr3:40491958 NA 0.5 8.71 0.43 1.42e-16 Renal cell carcinoma; LUSC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg03806693 chr22:41940476 POLR3H -1.05 -14.76 -0.63 2.55e-38 Vitiligo; LUSC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg16414030 chr3:133502952 NA -0.44 -6.99 -0.36 1.54e-11 Iron status biomarkers; LUSC trans rs3733585 0.648 rs35954357 chr4:9978758 G/C cg26043149 chr18:55253948 FECH 0.47 7.28 0.37 2.43e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg00071950 chr4:10020882 SLC2A9 0.67 11.22 0.52 5.3e-25 Bone mineral density; LUSC cis rs17376456 0.542 rs17083380 chr5:93170476 C/G cg21475434 chr5:93447410 FAM172A -0.41 -5.65 -0.3 3.38e-8 Diabetic retinopathy; LUSC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg20503657 chr10:835505 NA 0.46 6.26 0.32 1.19e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs79387448 0.745 rs1159509 chr2:103169073 T/A cg09003973 chr2:102972529 NA 0.89 8.63 0.43 2.45e-16 Gut microbiota (bacterial taxa); LUSC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg22532475 chr10:104410764 TRIM8 -0.35 -6.8 -0.35 4.95e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12760731 0.623 rs10913541 chr1:178347714 G/A cg00404053 chr1:178313656 RASAL2 0.48 5.82 0.3 1.38e-8 Obesity-related traits; LUSC cis rs365132 0.875 rs4976665 chr5:176352736 C/T cg25401027 chr5:176370377 UIMC1 0.36 5.85 0.31 1.15e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs16866061 0.962 rs16825685 chr2:225434256 C/G cg12698349 chr2:225449008 CUL3 0.85 13.97 0.61 3.14e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs61931739 0.517 rs2101396 chr12:34048927 T/A cg26384229 chr12:38710491 ALG10B 0.68 10.67 0.5 4.61e-23 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10189605 chr6:58287430 GUSBL2 0.42 6.52 0.34 2.6200000000000003e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs72960926 0.744 rs952120 chr6:74917250 T/G cg03266952 chr6:74778945 NA -0.82 -6.74 -0.35 6.85e-11 Metabolite levels (MHPG); LUSC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.08 -0.32 3.31e-9 Developmental language disorder (linguistic errors); LUSC trans rs7838490 0.780 rs74584457 chr8:89691016 T/G cg24558378 chr1:183589673 NA 0.34 6.27 0.32 1.09e-9 Body mass index and cholesterol (psychopharmacological treatment); LUSC cis rs62400317 0.826 rs62438867 chr6:45049787 G/A cg18551225 chr6:44695536 NA -0.42 -6.82 -0.35 4.17e-11 Total body bone mineral density; LUSC trans rs1908814 0.516 rs4841641 chr8:11798227 G/A cg27411982 chr8:10470053 RP1L1 0.42 6.48 0.33 3.29e-10 Neuroticism; LUSC trans rs8073060 0.586 rs225257 chr17:33956625 G/A cg19694781 chr19:47549865 TMEM160 -1.13 -18.17 -0.71 8.74e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7804356 1.000 rs12537323 chr7:26854388 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs2361710 0.668 rs2304855 chr17:78118266 T/A cg06718696 chr17:78121285 EIF4A3 0.44 6.34 0.33 7.44e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs9943753 0.508 rs7958071 chr12:109836089 G/A cg19025524 chr12:109796872 NA -0.38 -6.89 -0.35 2.77e-11 HDL cholesterol; LUSC cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs713477 0.505 rs8019209 chr14:55891329 C/T cg13175173 chr14:55914753 NA -0.31 -6.0 -0.31 5.09e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs921968 0.541 rs832798 chr2:219464810 G/A cg02176678 chr2:219576539 TTLL4 0.75 14.7 0.63 4.6e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 7.56 0.38 3.97e-13 Reticulocyte count; LUSC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg26818010 chr10:134567672 INPP5A -0.85 -11.2 -0.52 6.04e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs394563 0.591 rs805026 chr6:149728254 G/C cg07828024 chr6:149772892 ZC3H12D -0.33 -7.24 -0.37 3.16e-12 Dupuytren's disease; LUSC cis rs950776 0.518 rs12910978 chr15:78810017 A/G cg22563815 chr15:78856949 CHRNA5 0.27 6.41 0.33 4.82e-10 Sudden cardiac arrest; LUSC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg14558114 chr2:88469736 THNSL2 0.78 7.07 0.36 9.21e-12 Plasma clusterin levels; LUSC cis rs4930561 0.677 rs7946212 chr11:67982187 T/A cg04465784 chr11:67976953 SUV420H1 -0.29 -5.78 -0.3 1.7e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg23719950 chr11:63933701 MACROD1 -0.62 -8.08 -0.4 1.21e-14 Mean platelet volume; LUSC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg21918786 chr6:109611834 NA -0.38 -6.47 -0.33 3.45e-10 Reticulocyte fraction of red cells; LUSC cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg10172584 chr19:19639581 YJEFN3 -0.5 -5.9 -0.31 8.98e-9 Bipolar disorder; LUSC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.84 0.39 6.15e-14 Parkinson's disease; LUSC cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC cis rs8067287 0.762 rs11650981 chr17:16824038 A/G cg26910001 chr17:16838321 NA -0.48 -6.27 -0.32 1.11e-9 Diabetic kidney disease; LUSC cis rs8113142 0.668 rs55933947 chr19:29104647 A/T cg04546413 chr19:29218101 NA 0.43 5.9 0.31 8.86e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs6752107 0.936 rs6431660 chr2:234167234 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.73 12.11 0.55 3.07e-28 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7254114 0.578 rs4804574 chr19:11317482 G/A cg02815516 chr19:11306319 KANK2 0.4 8.23 0.41 4.16e-15 Immature fraction of reticulocytes; LUSC cis rs954108 0.809 rs1592059 chr13:29368961 G/A cg11788234 chr13:29393811 NA -0.38 -6.68 -0.34 1.01e-10 Obesity-related traits; LUSC cis rs12760731 0.720 rs12039605 chr1:178433368 C/T cg00404053 chr1:178313656 RASAL2 0.59 6.28 0.33 1.02e-9 Obesity-related traits; LUSC cis rs3931020 0.688 rs455032 chr1:75196488 C/T cg21906852 chr1:75198582 TYW3;CRYZ -0.44 -5.78 -0.3 1.69e-8 Resistin levels; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.19e-26 Prudent dietary pattern; LUSC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg06634786 chr22:41940651 POLR3H 0.51 6.1 0.32 2.91e-9 Vitiligo; LUSC cis rs9535307 0.696 rs9535305 chr13:50290415 A/T cg04663916 chr13:50265991 EBPL 0.49 5.71 0.3 2.44e-8 Obesity-related traits; LUSC cis rs7824557 0.767 rs2164273 chr8:11168499 A/G cg21775007 chr8:11205619 TDH 0.71 11.47 0.53 6.73e-26 Retinal vascular caliber; LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.83 0.63 1.46e-38 Platelet count; LUSC cis rs6845621 0.727 rs4697203 chr4:18920661 G/A cg12196642 chr4:18937545 NA -0.35 -6.55 -0.34 2.22e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9309473 0.615 rs11680965 chr2:73725916 G/T cg20560298 chr2:73613845 ALMS1 -0.55 -6.53 -0.34 2.47e-10 Metabolite levels; LUSC cis rs11997175 0.545 rs67960786 chr8:33668770 G/A ch.8.33884649F chr8:33765107 NA 0.5 7.17 0.37 4.86e-12 Body mass index; LUSC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg05855489 chr10:104503620 C10orf26 0.54 7.86 0.4 5.41e-14 Arsenic metabolism; LUSC cis rs1008375 0.843 rs59112113 chr4:17685336 A/T cg18681998 chr4:17616180 MED28 0.84 15.56 0.65 1.86e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1994135 0.617 rs2200155 chr12:33734935 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.46 0.33 3.7e-10 Resting heart rate; LUSC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg12463550 chr7:65579703 CRCP 0.51 7.32 0.37 1.85e-12 Aortic root size; LUSC cis rs367943 0.966 rs348924 chr5:112817930 T/G cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs7954584 0.616 rs10743186 chr12:122356436 C/T cg22618164 chr12:122356400 WDR66 0.55 7.77 0.39 9.9e-14 Mean corpuscular volume; LUSC cis rs61931739 0.534 rs11053049 chr12:34164537 T/C cg06521331 chr12:34319734 NA -0.45 -7.37 -0.37 1.36e-12 Morning vs. evening chronotype; LUSC cis rs250677 0.522 rs919730 chr5:148352401 T/C cg18129178 chr5:148520854 ABLIM3 0.51 7.14 0.36 5.79e-12 Breast cancer; LUSC cis rs12908161 1.000 rs56864281 chr15:85357649 C/A cg12863693 chr15:85201151 NMB 0.42 8.43 0.42 1.05e-15 Schizophrenia; LUSC cis rs2274273 1.000 rs8011834 chr14:55625977 A/C cg04306507 chr14:55594613 LGALS3 0.57 13.54 0.6 1.36e-33 Protein biomarker; LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg13395646 chr4:1353034 KIAA1530 -0.59 -9.2 -0.45 4.06e-18 Obesity-related traits; LUSC cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg26384229 chr12:38710491 ALG10B 0.86 14.6 0.62 1.12e-37 Bladder cancer; LUSC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg21017887 chr14:105400489 NA 0.68 12.95 0.58 2.24e-31 Rheumatoid arthritis; LUSC cis rs72634258 0.554 rs68024107 chr1:7914066 G/C cg00042356 chr1:8021962 PARK7 0.59 6.96 0.36 1.82e-11 Inflammatory bowel disease; LUSC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg13902645 chr11:5959945 NA -0.54 -7.82 -0.39 6.85e-14 DNA methylation (variation); LUSC trans rs6445525 1.000 rs9860098 chr3:65992808 A/G cg12639933 chr12:57626296 SHMT2 0.34 6.12 0.32 2.65e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12477438 0.765 rs10181422 chr2:99558970 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.52 -0.5 1.49e-22 Chronic sinus infection; LUSC cis rs6504663 0.586 rs60117965 chr17:48569755 G/A cg22571038 chr17:48585470 MYCBPAP 0.51 6.42 0.33 4.75e-10 Visceral fat; LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg14092988 chr3:52407081 DNAH1 0.31 5.92 0.31 8.21e-9 Bipolar disorder; LUSC cis rs2070488 0.689 rs6809352 chr3:38544349 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -12.45 -0.56 1.77e-29 Electrocardiographic conduction measures; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15227275 chr13:49107436 RCBTB2 0.49 7.61 0.38 2.91e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1568889 0.838 rs11030187 chr11:28044391 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 13.01 0.58 1.35e-31 Bipolar disorder; LUSC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg16325326 chr1:53192061 ZYG11B -0.97 -19.53 -0.73 3.44e-57 Monocyte count; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.41 0.42 1.2e-15 Prudent dietary pattern; LUSC cis rs9326248 0.861 rs7931335 chr11:117036805 C/T cg26566898 chr11:117069891 TAGLN 0.38 6.09 0.32 3.16e-9 Blood protein levels; LUSC cis rs10979 1.000 rs1416206 chr6:143889385 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs9788682 0.747 rs938682 chr15:78896547 A/G cg06917634 chr15:78832804 PSMA4 -0.5 -6.47 -0.33 3.53e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs60843830 0.550 rs300751 chr2:209063 A/C cg21211680 chr2:198530 NA 0.35 5.76 0.3 1.9e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7572733 0.555 rs6729473 chr2:198763928 G/A cg00792783 chr2:198669748 PLCL1 0.46 6.13 0.32 2.47e-9 Dermatomyositis; LUSC cis rs1865760 0.929 rs1816546 chr6:25938252 C/T cg17691542 chr6:26056736 HIST1H1C 0.5 7.26 0.37 2.72e-12 Height; LUSC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.14 0.41 8.09e-15 Axial length; LUSC cis rs4822044 0.617 rs13054514 chr22:42130383 A/G cg17376030 chr22:41985996 PMM1 -0.43 -5.82 -0.3 1.39e-8 Cannabis dependence symptom count; LUSC cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg06550200 chr5:1325588 CLPTM1L -0.67 -11.71 -0.54 8.94e-27 Lung cancer; LUSC cis rs7809950 0.953 rs2237670 chr7:107131485 A/G cg23024343 chr7:107201750 COG5 -0.55 -8.81 -0.43 7.13e-17 Coronary artery disease; LUSC cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.82 -0.3 1.38e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs981844 1.000 rs2118862 chr4:154657782 A/T cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.25 0.45 2.66e-18 Prudent dietary pattern; LUSC cis rs782590 0.608 rs10207590 chr2:55921782 G/C cg18811423 chr2:55921094 PNPT1 -0.79 -12.43 -0.56 2.13e-29 Metabolic syndrome; LUSC cis rs6121246 0.559 rs6058352 chr20:30269179 T/C cg13852791 chr20:30311386 BCL2L1 0.96 14.96 0.63 4.25e-39 Mean corpuscular hemoglobin; LUSC cis rs4663866 1.000 rs2304668 chr2:239168448 G/A cg16914508 chr2:239161102 PER2 0.65 6.76 0.35 6.17e-11 Irritable bowel syndrome; LUSC trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg15704280 chr7:45808275 SEPT13 0.73 8.21 0.41 4.83e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg27529037 chr20:44575021 PCIF1 0.42 7.36 0.37 1.43e-12 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10679755 chr3:146262421 PLSCR1 -0.42 -6.23 -0.32 1.44e-9 Electrocardiographic conduction measures; LUSC cis rs4474465 0.646 rs10793334 chr11:78278792 C/T cg27205649 chr11:78285834 NARS2 -0.59 -7.4 -0.38 1.14e-12 Alzheimer's disease (survival time); LUSC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.94 -0.81 2.8e-78 Height; LUSC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg09359103 chr1:154839909 KCNN3 0.58 11.93 0.55 1.48e-27 Prostate cancer; LUSC cis rs13394619 1.000 rs13394619 chr2:11727507 A/G cg07314298 chr2:11723111 GREB1 0.57 10.21 0.49 1.7e-21 Endometriosis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17913451 chr14:58619030 C14orf37 -0.47 -6.14 -0.32 2.29e-9 Hepatitis; LUSC cis rs1729951 0.575 rs1682356 chr3:136692037 T/C cg21827317 chr3:136751795 NA 0.39 6.96 0.36 1.84e-11 Neuroticism; LUSC trans rs1908814 0.516 rs13281315 chr8:11794855 C/G cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.7e-9 Neuroticism; LUSC trans rs10506458 1.000 rs10506458 chr12:63445092 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -15.62 -0.65 1.1e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs208520 0.690 rs207107 chr6:66794385 T/C cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg26354017 chr1:205819088 PM20D1 0.86 15.58 0.65 1.6e-41 Menarche (age at onset); LUSC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21023052 chr2:27009110 CENPA -0.4 -5.96 -0.31 6.46e-9 Electrocardiographic conduction measures; LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg08280861 chr8:58055591 NA 0.56 5.98 0.31 5.87e-9 Developmental language disorder (linguistic errors); LUSC cis rs6977660 1.000 rs5017193 chr7:19820103 G/A cg05791153 chr7:19748676 TWISTNB 0.52 5.78 0.3 1.69e-8 Thyroid stimulating hormone; LUSC cis rs8017423 0.967 rs11621045 chr14:90714003 C/T cg14092571 chr14:90743983 NA -0.36 -5.95 -0.31 6.68e-9 Mortality in heart failure; LUSC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg22442454 chr1:209979470 IRF6 0.45 5.97 0.31 6.07e-9 Cleft lip with or without cleft palate; LUSC cis rs870825 0.616 rs28558715 chr4:185627761 G/A cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg16797656 chr11:68205561 LRP5 -0.38 -6.26 -0.32 1.18e-9 Total body bone mineral density; LUSC trans rs11039798 0.588 rs584899 chr11:48431408 T/C cg15704280 chr7:45808275 SEPT13 -0.63 -7.0 -0.36 1.44e-11 Axial length; LUSC cis rs12973672 1.000 rs2280747 chr19:35770064 C/T cg12095397 chr19:35769544 USF2 0.44 6.86 0.35 3.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.61 0.34 1.5e-10 Menopause (age at onset); LUSC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg14196790 chr5:131705035 SLC22A5 -0.41 -6.72 -0.34 8e-11 Breast cancer;Mosquito bite size; LUSC cis rs939574 0.676 rs12694457 chr2:220134010 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.69 -6.74 -0.35 6.88e-11 Platelet distribution width; LUSC cis rs1865760 1.000 rs2071298 chr6:25914901 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 6.78 0.35 5.41e-11 Height; LUSC cis rs6938 0.597 rs4886641 chr15:75228655 C/A cg09165964 chr15:75287851 SCAMP5 0.54 7.92 0.4 3.53e-14 Breast cancer; LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs8078723 0.701 rs2305482 chr17:38140927 A/C cg17467752 chr17:38218738 THRA -0.7 -11.21 -0.52 5.91e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.65 8.4 0.42 1.27e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9326248 0.559 rs1269329 chr11:116755041 T/C cg11861562 chr11:117069780 TAGLN 0.34 6.59 0.34 1.76e-10 Blood protein levels; LUSC cis rs13089785 0.791 rs16834826 chr3:123584488 C/T cg01860459 chr3:123419554 MYLK -0.34 -5.73 -0.3 2.27e-8 Intelligence (multi-trait analysis); LUSC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg09034736 chr1:150693464 HORMAD1 0.51 7.51 0.38 5.57e-13 Tonsillectomy; LUSC cis rs7582180 0.764 rs10460478 chr2:100919735 G/A cg08017756 chr2:100939284 LONRF2 -0.44 -8.33 -0.41 2.09e-15 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.522 rs11776603 chr8:11020313 G/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.01 -0.36 1.36e-11 Triglycerides; LUSC cis rs1003719 0.715 rs7277820 chr21:38580309 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -9.98 -0.48 1.08e-20 Eye color traits; LUSC cis rs1185460 0.967 rs1786684 chr11:118938435 G/A cg23280166 chr11:118938394 VPS11 0.48 7.64 0.39 2.27e-13 Coronary artery disease; LUSC cis rs17270561 0.609 rs1179086 chr6:25791745 A/T cg16482183 chr6:26056742 HIST1H1C 0.53 7.53 0.38 4.66e-13 Iron status biomarkers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13630845 chr19:16682861 SLC35E1 0.77 6.92 0.35 2.32e-11 Cognitive performance; LUSC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg09165964 chr15:75287851 SCAMP5 0.46 6.65 0.34 1.23e-10 Caffeine consumption; LUSC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.5 7.74 0.39 1.23e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs11039216 1 rs11039216 chr11:47406592 C/T cg20307385 chr11:47447363 PSMC3 0.61 9.6 0.47 1.96e-19 Neuroticism; LUSC cis rs1371867 0.846 rs1660329 chr8:101304048 G/T cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.54e-15 Atrioventricular conduction; LUSC cis rs909341 0.710 rs2297433 chr20:62293460 T/C cg09650180 chr20:62225654 GMEB2 0.45 5.83 0.3 1.33e-8 Atopic dermatitis; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg25703541 chr22:24373054 LOC391322 -0.89 -14.49 -0.62 2.87e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg15704280 chr7:45808275 SEPT13 -0.45 -6.38 -0.33 5.91e-10 HDL cholesterol; LUSC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg07716408 chr11:68623521 NA -0.3 -5.78 -0.3 1.69e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9359856 0.564 rs72915904 chr6:90421412 C/A cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.89 -0.44 4e-17 Bipolar disorder; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.4 0.56 2.7e-29 Prudent dietary pattern; LUSC cis rs9362426 1.000 rs406900 chr6:88085447 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.39 6.19 0.32 1.8e-9 Depressive episodes in bipolar disorder; LUSC cis rs3931020 0.657 rs7522428 chr1:75178360 C/T cg21535942 chr1:75199100 CRYZ;TYW3 0.46 5.79 0.3 1.6e-8 Resistin levels; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg08736216 chr1:53307985 ZYG11A -0.3 -6.2 -0.32 1.62e-9 Monocyte count; LUSC cis rs6060717 0.610 rs2244883 chr20:34620896 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -6.37 -0.33 6.35e-10 Hip circumference adjusted for BMI; LUSC cis rs9905704 0.918 rs369184 chr17:56709086 C/T cg12560992 chr17:57184187 TRIM37 0.55 7.78 0.39 9.1e-14 Testicular germ cell tumor; LUSC cis rs72949976 1.000 rs6747328 chr2:214032156 C/G cg08319019 chr2:214017104 IKZF2 -0.62 -9.68 -0.47 1.11e-19 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg19875535 chr5:140030758 IK 0.55 9.02 0.44 1.48e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs8017423 0.967 rs11628812 chr14:90713720 G/T cg04374321 chr14:90722782 PSMC1 -0.74 -11.6 -0.54 2.34e-26 Mortality in heart failure; LUSC cis rs11792861 0.890 rs3750465 chr9:111900677 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.8 -0.35 4.81e-11 Menarche (age at onset); LUSC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg04450456 chr4:17643702 FAM184B 0.39 6.6 0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.67 9.99 0.48 1e-20 Chronic sinus infection; LUSC cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.5 0.46 4.15e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg13683864 chr3:40499215 RPL14 -1.01 -17.74 -0.7 4.38e-50 Renal cell carcinoma; LUSC trans rs7613875 0.620 rs34312088 chr3:50032133 C/T cg21659725 chr3:3221576 CRBN 0.54 8.6 0.43 3.15e-16 Body mass index; LUSC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.47e-24 Aortic root size; LUSC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.49e-11 Schizophrenia; LUSC cis rs7215564 0.818 rs1126064 chr17:78610388 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.19 0.32 1.81e-9 Myopia (pathological); LUSC cis rs6484504 0.576 rs208066 chr11:31156206 C/G cg14844989 chr11:31128820 NA -0.39 -6.23 -0.32 1.39e-9 Red blood cell count; LUSC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.04e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg18252515 chr7:66147081 NA -1.25 -14.0 -0.61 2.4e-35 Diabetic kidney disease; LUSC cis rs73198271 0.628 rs11780486 chr8:8589494 C/T cg01851573 chr8:8652454 MFHAS1 -0.46 -5.76 -0.3 1.87e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6138458 0.626 rs6050261 chr20:25014206 C/T cg06937882 chr20:24974362 C20orf3 -0.3 -5.71 -0.3 2.5e-8 Blood protein levels; LUSC cis rs10865541 0.806 rs4971503 chr2:3417221 G/A cg15807143 chr2:3452624 TTC15 0.32 5.66 0.3 3.24e-8 Obesity-related traits; LUSC cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg08330031 chr10:104623503 C10orf32 0.32 5.68 0.3 2.86e-8 Arsenic metabolism; LUSC trans rs11722228 0.549 rs62288521 chr4:10099772 G/A cg26043149 chr18:55253948 FECH 0.98 14.93 0.63 5.84e-39 Gout;Urate levels;Serum uric acid levels; LUSC cis rs8114671 0.967 rs3746427 chr20:33730464 A/G cg24642439 chr20:33292090 TP53INP2 0.4 5.8 0.3 1.56e-8 Height; LUSC cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg20476274 chr7:133979776 SLC35B4 0.8 13.27 0.59 1.42e-32 Mean platelet volume; LUSC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg06112835 chr11:68658793 MRPL21 0.5 7.74 0.39 1.22e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg01503450 chr10:980765 NA -0.39 -5.79 -0.3 1.59e-8 Eosinophil percentage of granulocytes; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -12.16 -0.55 2.05e-28 Platelet count; LUSC cis rs6967385 0.560 rs10434998 chr7:12348375 C/T cg06484146 chr7:12443880 VWDE 0.51 7.58 0.38 3.46e-13 Response to taxane treatment (placlitaxel); LUSC trans rs853679 0.607 rs71559070 chr6:28038929 G/A cg06606381 chr12:133084897 FBRSL1 -1.06 -9.46 -0.46 5.85e-19 Depression; LUSC cis rs858239 0.601 rs11982002 chr7:23163270 C/T cg23682824 chr7:23144976 KLHL7 0.4 5.77 0.3 1.85e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs8141529 0.687 rs6005867 chr22:29165120 T/C cg02153584 chr22:29168773 CCDC117 0.67 10.29 0.49 9.5e-22 Lymphocyte counts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00119011 chr13:45694603 GTF2F2 0.44 5.95 0.31 6.69e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6502050 0.805 rs7225560 chr17:80160884 C/G cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.34e-10 Life satisfaction; LUSC cis rs17270561 0.609 rs4712970 chr6:25770707 G/A cg16482183 chr6:26056742 HIST1H1C 0.56 7.66 0.39 2e-13 Iron status biomarkers; LUSC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.08 0.52 1.65e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg12963246 chr6:28129442 ZNF389 0.54 7.74 0.39 1.2e-13 Parkinson's disease; LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.66 -10.42 -0.5 3.4e-22 Prudent dietary pattern; LUSC cis rs7267979 1.000 rs6083856 chr20:25407585 C/T cg08601574 chr20:25228251 PYGB -0.45 -6.89 -0.35 2.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg12372898 chr4:77069563 NUP54 0.75 6.18 0.32 1.83e-9 Cognitive performance; LUSC cis rs11785400 0.731 rs4644221 chr8:143736984 C/T cg24634471 chr8:143751801 JRK -0.52 -7.52 -0.38 5e-13 Schizophrenia; LUSC cis rs2414059 0.518 rs11070776 chr15:50735488 G/A cg08437265 chr15:50716283 USP8 0.4 5.78 0.3 1.69e-8 QT interval; LUSC cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg21535247 chr6:8435926 SLC35B3 0.57 9.02 0.44 1.5e-17 Motion sickness; LUSC cis rs10186029 0.509 rs13387516 chr2:213945341 T/C cg08319019 chr2:214017104 IKZF2 -0.43 -6.31 -0.33 9.01e-10 Systemic sclerosis; LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg16325326 chr1:53192061 ZYG11B -0.83 -14.56 -0.62 1.63e-37 Monocyte count; LUSC cis rs36093844 0.800 rs76464398 chr11:85583898 C/T cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs62103177 0.810 rs62103175 chr18:77622467 C/T cg05926928 chr17:57297772 GDPD1 1.42 16.71 0.67 5.66e-46 Opioid sensitivity; LUSC cis rs7617773 0.817 rs9853804 chr3:48327729 T/C cg20734569 chr3:48348370 SPINK8 -0.47 -8.17 -0.41 6.44e-15 Coronary artery disease; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg25767906 chr1:53392781 SCP2 -0.57 -11.24 -0.52 4.57e-25 Monocyte count; LUSC cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.33 -0.37 1.77e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs7909074 0.966 rs4948645 chr10:45391481 A/G cg05187965 chr10:45406764 TMEM72 -0.37 -8.68 -0.43 1.73e-16 Mean corpuscular volume; LUSC cis rs96067 0.711 rs272833 chr1:36622870 C/G cg24686825 chr1:36642396 MAP7D1 -0.72 -11.19 -0.52 6.85e-25 Corneal structure; LUSC cis rs11893307 0.507 rs1465304 chr2:191585398 A/G cg11845111 chr2:191398756 TMEM194B -0.42 -5.7 -0.3 2.6e-8 Mean platelet volume; LUSC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.44 -0.33 4.08e-10 Alzheimer's disease (late onset); LUSC cis rs4953076 0.533 rs10173126 chr2:44446492 T/C cg04920474 chr2:44395004 PPM1B 0.63 8.13 0.41 8.32e-15 Height; LUSC cis rs72781680 0.716 rs2712068 chr2:23984000 A/G cg08917208 chr2:24149416 ATAD2B 0.58 6.56 0.34 2.06e-10 Lymphocyte counts; LUSC cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg05985134 chr18:33552581 C18orf21 0.51 7.03 0.36 1.17e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10979 0.931 rs9403509 chr6:143888691 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07162665 chr17:77020549 C1QTNF1 -0.42 -6.13 -0.32 2.44e-9 Electrocardiographic conduction measures; LUSC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg27170947 chr2:26402098 FAM59B -0.63 -9.08 -0.44 9.99e-18 Gut microbiome composition (summer); LUSC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -6.92 -0.35 2.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs7914558 1.000 rs7077291 chr10:104945751 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.76 0.47 5.68e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg08439880 chr3:133502540 NA -0.33 -6.01 -0.31 4.89e-9 Iron status biomarkers; LUSC cis rs12973672 0.812 rs13345192 chr19:35756155 A/C cg12095397 chr19:35769544 USF2 -0.46 -6.92 -0.35 2.36e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.2 0.32 1.69e-9 Multiple sclerosis; LUSC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 1.97e-12 Subjective well-being; LUSC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg16339924 chr4:17578868 LAP3 0.49 7.52 0.38 4.97e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7084921 0.549 rs9888058 chr10:101859205 C/T cg02250046 chr10:101825185 CPN1 -0.34 -6.42 -0.33 4.77e-10 Bone mineral density; LUSC cis rs7592578 0.640 rs56127319 chr2:191296429 G/A cg11845111 chr2:191398756 TMEM194B -0.81 -10.66 -0.5 5.07e-23 Diastolic blood pressure; LUSC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg00825309 chr19:58991885 ZNF446 -0.5 -7.23 -0.37 3.27e-12 Uric acid clearance; LUSC trans rs1998174 0.509 rs1076700 chr1:171826943 C/T cg13482142 chr2:234261155 NA 0.42 6.09 0.32 3.11e-9 Platelet distribution width; LUSC cis rs2281845 0.507 rs7547762 chr1:201088245 A/G cg22815214 chr1:201083145 CACNA1S 0.46 6.69 0.34 9.7e-11 Permanent tooth development; LUSC cis rs1003719 0.715 rs2835647 chr21:38546773 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.31 0.53 2.56e-25 Prudent dietary pattern; LUSC trans rs61931739 0.534 rs11052983 chr12:34045787 C/A cg13010199 chr12:38710504 ALG10B 0.53 7.95 0.4 2.82e-14 Morning vs. evening chronotype; LUSC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.36 0.42 1.76e-15 Hemoglobin concentration; LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg00814883 chr7:100076585 TSC22D4 -0.66 -8.64 -0.43 2.36e-16 Platelet count; LUSC cis rs6687430 0.532 rs17035305 chr1:10616505 C/A cg20482658 chr1:10539492 PEX14 0.28 5.67 0.3 3.1e-8 Hand grip strength; LUSC cis rs7267979 1.000 rs2259926 chr20:25281733 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7584330 0.666 rs72620818 chr2:238354652 G/A cg14458575 chr2:238380390 NA 0.85 15.01 0.63 2.87e-39 Prostate cancer; LUSC cis rs3806843 0.735 rs813897 chr5:140070029 T/C cg19875535 chr5:140030758 IK -0.53 -8.76 -0.43 1.02e-16 Depressive symptoms (multi-trait analysis); LUSC trans rs4718428 0.705 rs12698547 chr7:66278258 T/C cg18876405 chr7:65276391 NA 0.47 6.36 0.33 6.75e-10 Corneal structure; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs2795502 1.000 rs1852959 chr10:43359636 T/C cg27426351 chr10:43362370 NA 0.46 6.27 0.32 1.12e-9 Blood protein levels; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg21280719 chr6:42927975 GNMT -0.3 -7.67 -0.39 1.89e-13 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs629535 0.814 rs78813708 chr8:70073977 A/G cg21567404 chr3:27674614 NA 0.96 15.11 0.64 1.15e-39 Dupuytren's disease; LUSC cis rs7296418 0.961 rs4148863 chr12:123569375 A/G cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.44 -0.42 9.56e-16 Platelet count; LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.75 0.65 3.43e-42 Platelet count; LUSC cis rs9325144 0.581 rs6582564 chr12:38671282 G/A cg13010199 chr12:38710504 ALG10B -0.53 -8.1 -0.41 1.03e-14 Morning vs. evening chronotype; LUSC cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs28595532 1.000 rs41455648 chr4:119718030 A/G cg02775129 chr4:119771670 NA -0.81 -6.3 -0.33 9.24e-10 Cannabis dependence symptom count; LUSC cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg26384229 chr12:38710491 ALG10B 0.84 13.8 0.6 1.32e-34 Bladder cancer; LUSC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg02079420 chr8:82753780 SNX16 0.4 6.74 0.35 6.94e-11 Diastolic blood pressure; LUSC trans rs6598955 0.671 rs17257169 chr1:26570009 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.1 -0.41 1.01e-14 Obesity-related traits; LUSC cis rs9868809 0.881 rs13324142 chr3:48669447 C/T cg01304814 chr3:48885189 PRKAR2A 0.6 5.65 0.3 3.45e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs12776158 0.901 rs59145567 chr10:71217065 G/T cg12610070 chr10:71211762 TSPAN15 -0.46 -5.91 -0.31 8.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs6952808 0.692 rs12666575 chr7:2004421 C/T cg04565464 chr8:145669602 NFKBIL2 0.36 6.03 0.31 4.33e-9 Bipolar disorder and schizophrenia; LUSC trans rs9650657 0.537 rs4841457 chr8:10773511 T/G cg15556689 chr8:8085844 FLJ10661 -0.54 -7.88 -0.4 4.59e-14 Neuroticism; LUSC cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg14844989 chr11:31128820 NA 0.4 6.14 0.32 2.34e-9 Bone mineral density (spine); LUSC trans rs9291683 0.609 rs55959894 chr4:10026580 G/A cg26043149 chr18:55253948 FECH 0.51 7.59 0.38 3.26e-13 Bone mineral density; LUSC cis rs1908814 0.516 rs4367597 chr8:11793529 C/T cg21775007 chr8:11205619 TDH 0.47 6.67 0.34 1.09e-10 Neuroticism; LUSC cis rs62400317 0.762 rs62436375 chr6:44875818 T/C cg20913747 chr6:44695427 NA -0.48 -7.44 -0.38 8.79e-13 Total body bone mineral density; LUSC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg04282206 chr17:62833786 PLEKHM1P -0.41 -6.01 -0.31 4.75e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs11249608 0.548 rs7732719 chr5:178463054 A/G cg21905437 chr5:178450457 ZNF879 0.43 5.67 0.3 3.1e-8 Pubertal anthropometrics; LUSC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg26958806 chr6:27640298 NA 0.59 5.68 0.3 2.86e-8 Depression; LUSC cis rs6087771 0.642 rs6060403 chr20:30221104 C/A cg13852791 chr20:30311386 BCL2L1 0.82 10.75 0.51 2.37e-23 Subcortical brain region volumes;Putamen volume; LUSC cis rs11098499 0.754 rs7689729 chr4:120256192 A/G cg24375607 chr4:120327624 NA 0.77 12.51 0.56 1.08e-29 Corneal astigmatism; LUSC cis rs3845702 0.736 rs2367990 chr2:180843126 C/T cg01881094 chr2:180872142 CWC22 -1.04 -12.46 -0.56 1.56e-29 Schizophrenia; LUSC trans rs7824557 0.527 rs4631425 chr8:11239054 C/T cg15556689 chr8:8085844 FLJ10661 -0.47 -7.29 -0.37 2.2e-12 Retinal vascular caliber; LUSC cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg04117972 chr1:227635322 NA 0.53 6.22 0.32 1.46e-9 Major depressive disorder; LUSC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg23711669 chr6:146136114 FBXO30 0.82 14.9 0.63 7.22e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg13628971 chr7:2884303 GNA12 -0.48 -6.92 -0.35 2.32e-11 Height; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg09436375 chr6:42928200 GNMT -0.29 -6.77 -0.35 5.94e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg13319975 chr6:146136371 FBXO30 0.48 7.25 0.37 3.01e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs12931792 0.720 rs12102320 chr16:30178516 A/C cg17640201 chr16:30407289 ZNF48 0.63 10.3 0.49 8.45e-22 Tonsillectomy; LUSC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg09034736 chr1:150693464 HORMAD1 0.46 6.73 0.35 7.26e-11 Tonsillectomy; LUSC cis rs1461503 0.548 rs7114175 chr11:122813983 A/T cg27398637 chr11:122830231 C11orf63 -0.39 -6.44 -0.33 4.05e-10 Menarche (age at onset); LUSC cis rs2180341 0.576 rs2057224 chr6:127624414 C/G cg27446573 chr6:127587934 RNF146 0.64 10.35 0.49 6.01e-22 Breast cancer; LUSC cis rs12208915 0.731 rs9448581 chr6:79553378 A/G cg05283184 chr6:79620031 NA -0.46 -7.04 -0.36 1.07e-11 Left atrial antero-posterior diameter; LUSC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg01368799 chr11:117014884 PAFAH1B2 0.47 6.21 0.32 1.62e-9 Blood protein levels; LUSC cis rs11676348 0.774 rs11683524 chr2:218984604 G/A cg06547715 chr2:218990976 CXCR2 0.31 5.78 0.3 1.69e-8 Ulcerative colitis; LUSC cis rs2050392 0.767 rs1536833 chr10:30699265 C/T cg18806716 chr10:30721971 MAP3K8 0.72 11.44 0.53 8.58e-26 Inflammatory bowel disease; LUSC cis rs4253772 0.591 rs11704586 chr22:46685274 T/C cg24881330 chr22:46731750 TRMU 0.82 7.29 0.37 2.32e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg26924012 chr15:45694286 SPATA5L1 1.12 20.85 0.75 2.06e-62 Homoarginine levels; LUSC trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg08999081 chr20:33150536 PIGU 0.53 10.2 0.49 1.9e-21 Coronary artery disease; LUSC cis rs6964587 0.933 rs6465350 chr7:91768615 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.48e-8 Breast cancer; LUSC trans rs6502050 0.871 rs11870632 chr17:80075406 T/C cg07393940 chr7:158741817 NA -0.37 -6.54 -0.34 2.29e-10 Life satisfaction; LUSC cis rs2282300 0.653 rs67745574 chr11:30234839 C/T cg06241208 chr11:30344200 C11orf46 -0.45 -5.67 -0.3 3.12e-8 Morning vs. evening chronotype; LUSC cis rs6696846 0.777 rs9651228 chr1:205049383 A/G cg21545522 chr1:205238299 TMCC2 0.42 7.99 0.4 2.22e-14 Red blood cell count; LUSC cis rs3772130 0.962 rs9812137 chr3:121539103 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.68 10.13 0.48 3.31e-21 Cognitive performance; LUSC cis rs12586317 0.620 rs12437439 chr14:35585669 C/A cg05294307 chr14:35346193 BAZ1A -0.58 -6.94 -0.35 2.1e-11 Psoriasis; LUSC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg00310523 chr12:86230176 RASSF9 0.54 10.15 0.49 2.75e-21 Major depressive disorder; LUSC trans rs1325195 0.843 rs390018 chr1:179215747 T/C cg11624085 chr17:8464688 MYH10 0.44 7.1 0.36 7.33e-12 IgE grass sensitization; LUSC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg09323728 chr8:95962352 TP53INP1 0.33 6.46 0.33 3.71e-10 Type 2 diabetes; LUSC cis rs4478858 0.735 rs7523438 chr1:31788313 C/T cg00250761 chr1:31883323 NA 0.37 8.78 0.43 8.83e-17 Alcohol dependence; LUSC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg24549020 chr5:56110836 MAP3K1 0.51 5.81 0.3 1.42e-8 Initial pursuit acceleration; LUSC cis rs3008870 0.755 rs1925409 chr1:67365089 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.76 -12.55 -0.57 7.08e-30 Lymphocyte percentage of white cells; LUSC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.545 rs10883847 chr10:104958284 C/T cg23093090 chr10:104574429 C10orf26 -0.34 -6.25 -0.32 1.25e-9 Arsenic metabolism; LUSC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg16339924 chr4:17578868 LAP3 0.56 8.62 0.43 2.63e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg12927641 chr6:109611667 NA -0.35 -5.88 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs4566357 0.615 rs2272200 chr2:227912331 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.29 -0.41 2.72e-15 Coronary artery disease; LUSC cis rs1775715 0.870 rs7912121 chr10:32228995 T/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.7 0.34 9.02e-11 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs11039798 0.511 rs2047812 chr11:48162042 A/G cg03929089 chr4:120376271 NA -0.6 -6.52 -0.34 2.61e-10 Axial length; LUSC cis rs1577917 0.740 rs7771612 chr6:86264374 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 9.12 0.45 7.31e-18 Response to antipsychotic treatment; LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg27284194 chr4:1044797 NA -0.36 -5.86 -0.31 1.13e-8 Obesity-related traits; LUSC cis rs9811920 0.931 rs7629487 chr3:99860401 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.35 -5.92 -0.31 7.84e-9 Axial length; LUSC cis rs9611565 0.500 rs2011053 chr22:42121278 G/A cg03806693 chr22:41940476 POLR3H 0.86 12.76 0.57 1.23e-30 Vitiligo; LUSC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg06481639 chr22:41940642 POLR3H -0.53 -5.9 -0.31 8.87e-9 Vitiligo; LUSC cis rs1595825 0.891 rs57990618 chr2:198660838 C/T cg00982548 chr2:198649783 BOLL -0.58 -7.15 -0.36 5.37e-12 Ulcerative colitis; LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.84 0.39 6.15e-14 Prudent dietary pattern; LUSC cis rs6961069 0.585 rs1722507 chr7:80238710 C/T cg04458919 chr7:80252533 CD36 0.4 7.32 0.37 1.91e-12 Platelet count; LUSC cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg05985134 chr18:33552581 C18orf21 0.53 7.26 0.37 2.74e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs3733585 0.683 rs6449140 chr4:9936437 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -8.91 -0.44 3.44e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6445967 0.530 rs12495722 chr3:58401595 C/T cg13705284 chr3:58523313 ACOX2 -0.27 -5.66 -0.3 3.28e-8 Platelet count; LUSC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg01097406 chr16:89675127 NA -0.34 -6.73 -0.35 7.39e-11 Vitiligo; LUSC trans rs7613875 0.600 rs2856238 chr3:50158191 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.52 8.1 0.41 1.02e-14 Body mass index; LUSC cis rs877282 0.786 rs11253392 chr10:788768 G/A cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs10791097 0.739 rs735094 chr11:130725109 G/C cg12179176 chr11:130786555 SNX19 0.73 11.42 0.53 1e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs11997175 0.624 rs4526317 chr8:33682936 T/A ch.8.33884649F chr8:33765107 NA 0.48 7.09 0.36 7.95e-12 Body mass index; LUSC cis rs7089973 0.668 rs61868024 chr10:116637939 A/G cg25233709 chr10:116636983 FAM160B1 0.39 6.59 0.34 1.7e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11690935 0.550 rs62183769 chr2:172838074 A/C cg13550731 chr2:172543902 DYNC1I2 0.5 7.44 0.38 8.64e-13 Schizophrenia; LUSC cis rs11608355 0.810 rs2217972 chr12:109857612 C/T cg05360138 chr12:110035743 NA 0.6 8.06 0.4 1.34e-14 Neuroticism; LUSC cis rs9549260 0.755 rs1923249 chr13:41143881 C/A cg21288729 chr13:41239152 FOXO1 0.58 8.69 0.43 1.62e-16 Red blood cell count; LUSC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg09455208 chr3:40491958 NA 0.53 9.45 0.46 6.16e-19 Renal cell carcinoma; LUSC cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg06064525 chr11:970664 AP2A2 -0.36 -7.17 -0.37 4.92e-12 Alzheimer's disease (late onset); LUSC cis rs10144321 0.729 rs8018305 chr14:100829848 C/T cg14882082 chr14:100845427 WDR25 -0.39 -7.47 -0.38 7.23e-13 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06548519 chr17:34267111 LYZL6 -0.44 -6.72 -0.35 7.76e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9300255 0.596 rs11057207 chr12:123730891 T/G cg00376283 chr12:123451042 ABCB9 0.69 9.81 0.47 3.82e-20 Neutrophil percentage of white cells; LUSC trans rs11098499 0.863 rs3775844 chr4:120428033 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.7e-10 Corneal astigmatism; LUSC cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.86 0.31 1.1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1790761 0.658 rs666328 chr11:67335538 G/A cg00290607 chr11:67383545 NA 0.37 6.88 0.35 3.04e-11 Mean corpuscular volume; LUSC cis rs4820294 1.000 rs62236667 chr22:38061520 C/G cg21798802 chr22:38057573 PDXP 0.48 10.64 0.5 6.02e-23 Fat distribution (HIV); LUSC cis rs4588572 0.644 rs10805920 chr5:77698222 G/A cg11547950 chr5:77652471 NA -0.41 -6.26 -0.32 1.19e-9 Triglycerides; LUSC cis rs727505 0.954 rs28728448 chr7:124532938 T/A cg23710748 chr7:124431027 NA -0.41 -7.34 -0.37 1.61e-12 Lewy body disease; LUSC cis rs136211 0.640 rs9610495 chr22:36760838 G/A cg16924664 chr22:36878180 TXN2 0.4 5.97 0.31 6.12e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6696846 0.765 rs11577406 chr1:205065733 G/T cg21643547 chr1:205240462 TMCC2 -0.43 -7.82 -0.39 7.16e-14 Red blood cell count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17866734 chr6:43484657 YIPF3;POLR1C 0.45 6.18 0.32 1.92e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg20607287 chr7:12443886 VWDE -0.65 -6.59 -0.34 1.74e-10 Coronary artery disease; LUSC cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg26408565 chr15:76604113 ETFA -0.52 -8.39 -0.42 1.4e-15 Blood metabolite levels; LUSC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg06618935 chr21:46677482 NA -0.4 -8.06 -0.4 1.41e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.43 5.99 0.31 5.3e-9 Height; LUSC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg24838063 chr12:130822603 PIWIL1 0.69 10.73 0.51 2.84e-23 Menopause (age at onset); LUSC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg11663144 chr21:46675770 NA -0.4 -7.32 -0.37 1.82e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg06552810 chr11:31128660 NA -0.42 -7.39 -0.37 1.19e-12 Red blood cell count; LUSC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg10130564 chr11:117069849 TAGLN 0.38 6.16 0.32 2.12e-9 Blood protein levels; LUSC cis rs4253772 0.938 rs11704979 chr22:46632994 G/A cg18190219 chr22:46762943 CELSR1 -0.51 -5.92 -0.31 7.92e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4631830 0.900 rs10763534 chr10:51534920 C/T cg10326726 chr10:51549505 MSMB -0.37 -6.38 -0.33 5.76e-10 Prostate-specific antigen levels; LUSC trans rs804280 0.560 rs10503426 chr8:11589383 A/C cg15556689 chr8:8085844 FLJ10661 0.51 7.38 0.37 1.23e-12 Myopia (pathological); LUSC cis rs17401966 0.838 rs7553228 chr1:10350438 G/C cg19773385 chr1:10388646 KIF1B -0.5 -8.66 -0.43 2.11e-16 Hepatocellular carcinoma; LUSC trans rs637571 0.522 rs649000 chr11:65742933 T/C cg17712092 chr4:129076599 LARP1B 0.74 11.11 0.52 1.3e-24 Eosinophil percentage of white cells; LUSC cis rs5769707 0.656 rs135878 chr22:50014369 T/A cg05373962 chr22:49881684 NA -0.41 -8.5 -0.42 6.21e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2637266 0.935 rs2583054 chr10:78401442 A/G cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs4566357 0.576 rs10187255 chr2:227913442 T/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.27 -0.41 3.17e-15 Coronary artery disease; LUSC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg13939156 chr17:80058883 NA -0.33 -6.52 -0.34 2.65e-10 Life satisfaction; LUSC cis rs8062405 0.964 rs7187333 chr16:28865916 G/A cg09754948 chr16:28834200 ATXN2L 0.41 5.86 0.31 1.13e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9283706 0.676 rs6449842 chr5:66323159 C/G cg11590213 chr5:66331682 MAST4 0.44 6.59 0.34 1.72e-10 Coronary artery disease; LUSC cis rs9527 0.615 rs7096452 chr10:104736563 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.55 0.46 2.83e-19 Arsenic metabolism; LUSC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.47 -0.42 7.71e-16 Cystic fibrosis severity; LUSC cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg24642439 chr20:33292090 TP53INP2 0.73 12.03 0.55 6.04e-28 Coronary artery disease; LUSC cis rs7202877 0.610 rs10871307 chr16:75335114 G/T cg04384234 chr16:75411784 CFDP1 -0.58 -7.44 -0.38 8.37e-13 Type 2 diabetes;Type 1 diabetes; LUSC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg14668632 chr7:2872130 GNA12 0.43 6.45 0.33 4.01e-10 Height; LUSC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg00074818 chr8:8560427 CLDN23 0.56 9.41 0.46 8.06e-19 Obesity-related traits; LUSC cis rs1670533 1.000 rs6822863 chr4:1055606 G/A cg27284194 chr4:1044797 NA 0.6 8.92 0.44 3.1e-17 Recombination rate (females); LUSC cis rs8099014 1.000 rs8096440 chr18:56127985 T/A cg12907477 chr18:56117327 MIR122 0.44 6.99 0.36 1.52e-11 Platelet count; LUSC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.48 0.75 5.81e-61 Prudent dietary pattern; LUSC cis rs10489202 1.000 rs67600256 chr1:167972357 T/C cg24449463 chr1:168025552 DCAF6 -0.58 -7.27 -0.37 2.56e-12 Schizophrenia; LUSC cis rs2486288 0.656 rs11632651 chr15:45550838 C/T cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.8 -0.51 1.62e-23 Glomerular filtration rate; LUSC cis rs6901250 0.655 rs1398403 chr6:117122646 T/C cg12892004 chr6:117198278 RFX6 0.4 7.59 0.38 3.13e-13 C-reactive protein levels; LUSC cis rs2361718 0.967 rs12942941 chr17:78103013 C/T cg27427491 chr17:78079615 GAA -0.34 -6.69 -0.34 9.27e-11 Yeast infection; LUSC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg00745463 chr17:30367425 LRRC37B -0.77 -9.2 -0.45 3.98e-18 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.31 -0.37 1.96e-12 Developmental language disorder (linguistic errors); LUSC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg04111992 chr7:158790115 NA -0.47 -7.47 -0.38 7.1e-13 Facial morphology (factor 20); LUSC cis rs3858526 0.792 rs12363478 chr11:5987775 C/T cg13902645 chr11:5959945 NA -0.6 -8.33 -0.41 2.16e-15 DNA methylation (variation); LUSC cis rs3087591 1.000 rs2905795 chr17:29547601 A/G cg24425628 chr17:29625626 OMG;NF1 0.59 8.82 0.43 6.48e-17 Hip circumference; LUSC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg18876405 chr7:65276391 NA 0.55 8.56 0.42 4.15e-16 Aortic root size; LUSC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg21251018 chr6:28226885 NKAPL 0.32 6.03 0.31 4.39e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg13319975 chr6:146136371 FBXO30 0.51 7.67 0.39 1.94e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg06740227 chr12:86229804 RASSF9 0.37 5.82 0.3 1.39e-8 Major depressive disorder; LUSC cis rs7131987 0.650 rs10843384 chr12:29472409 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.77 -0.35 5.69e-11 QT interval; LUSC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg20203395 chr5:56204925 C5orf35 -0.46 -6.74 -0.35 6.95e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs2952156 0.920 rs14050 chr17:37828072 C/T cg20243544 chr17:37824526 PNMT 0.5 7.13 0.36 6.18e-12 Asthma; LUSC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg12963246 chr6:28129442 ZNF389 -0.55 -7.87 -0.4 5.14e-14 Parkinson's disease; LUSC trans rs2243480 1.000 rs781157 chr7:65478311 G/A cg10756647 chr7:56101905 PSPH 0.85 8.31 0.41 2.5e-15 Diabetic kidney disease; LUSC cis rs2898681 0.519 rs6554057 chr4:53730147 A/T cg00791764 chr4:53727839 RASL11B 0.56 7.7 0.39 1.6e-13 Optic nerve measurement (cup area); LUSC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6479527 0.625 rs1933667 chr9:96744109 G/C cg14459158 chr9:96720562 NA 0.33 6.64 0.34 1.3e-10 Esophageal adenocarcinoma; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.6 -10.06 -0.48 5.67e-21 Lymphocyte counts; LUSC trans rs11992162 0.597 rs6996342 chr8:11784541 C/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.22 -0.32 1.52e-9 Monocyte count; LUSC trans rs7939886 0.920 rs11227273 chr11:55893034 T/G cg15704280 chr7:45808275 SEPT13 0.81 6.68 0.34 9.89e-11 Myopia (pathological); LUSC cis rs1957429 0.614 rs73279834 chr14:65352544 G/A cg23373153 chr14:65346875 NA -0.99 -8.98 -0.44 1.97e-17 Pediatric areal bone mineral density (radius); LUSC cis rs9837602 1.000 rs9873878 chr3:99711816 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.17 0.32 1.96e-9 Breast cancer; LUSC cis rs1413885 0.516 rs6588138 chr1:65838366 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.47 7.06 0.36 1e-11 Anticoagulant levels; LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg19266014 chr7:2183958 MAD1L1 -0.34 -5.69 -0.3 2.85e-8 Bipolar disorder and schizophrenia; LUSC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg23172400 chr8:95962367 TP53INP1 -0.4 -8.06 -0.4 1.37e-14 Type 2 diabetes; LUSC cis rs10743315 0.547 rs7310796 chr12:19362390 C/T cg02471346 chr12:19282374 PLEKHA5 -0.46 -5.76 -0.3 1.95e-8 Gut microbiota (bacterial taxa); LUSC cis rs12973672 0.812 rs2073899 chr19:35752917 C/T cg12095397 chr19:35769544 USF2 0.43 6.63 0.34 1.32e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs921968 0.541 rs588770 chr2:219494638 T/C cg02176678 chr2:219576539 TTLL4 0.74 14.43 0.62 5.06e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs1950626 0.623 rs2295657 chr14:101430620 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.38 0.37 1.25e-12 Pelvic organ prolapse (moderate/severe); LUSC cis rs11645898 0.935 rs11647125 chr16:72243277 T/C cg14768367 chr16:72042858 DHODH -0.57 -6.26 -0.32 1.15e-9 Blood protein levels; LUSC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg11871910 chr12:69753446 YEATS4 0.83 14.58 0.62 1.34e-37 Blood protein levels; LUSC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.71e-13 Bipolar disorder; LUSC trans rs12643440 0.526 rs10025799 chr4:17224345 A/G cg03061682 chr15:28352098 NA 0.37 6.16 0.32 2.07e-9 Metabolite levels (Pyroglutamine); LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg14893161 chr1:205819251 PM20D1 0.5 7.45 0.38 8.22e-13 Prostate-specific antigen levels; LUSC cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg17063962 chr7:91808500 NA 0.58 9.34 0.46 1.35e-18 Breast cancer; LUSC cis rs854765 0.583 rs8065563 chr17:17782404 A/G cg16928487 chr17:17741425 SREBF1 -0.47 -9.28 -0.45 2.15e-18 Total body bone mineral density; LUSC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg13683864 chr3:40499215 RPL14 -0.97 -16.36 -0.67 1.35e-44 Renal cell carcinoma; LUSC cis rs7851660 0.967 rs7049054 chr9:100599969 T/G cg13688889 chr9:100608707 NA -0.61 -10.38 -0.49 4.54e-22 Strep throat; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg08742575 chr21:47604166 C21orf56 -0.42 -6.26 -0.32 1.2e-9 Testicular germ cell tumor; LUSC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg07424592 chr7:64974309 NA 0.69 6.07 0.32 3.4e-9 Diabetic kidney disease; LUSC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg01842473 chr11:617407 IRF7;MUPCDH -0.61 -7.78 -0.39 9.36e-14 Systemic lupus erythematosus; LUSC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg12310025 chr6:25882481 NA -0.4 -7.12 -0.36 6.59e-12 Height; LUSC cis rs4631830 0.863 rs2843546 chr10:51518688 A/C cg10326726 chr10:51549505 MSMB -0.36 -6.09 -0.32 3.1e-9 Prostate-specific antigen levels; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg11494091 chr17:61959527 GH2 0.64 13.56 0.6 1.13e-33 Prudent dietary pattern; LUSC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.4 -5.73 -0.3 2.2e-8 Tonsillectomy; LUSC cis rs7191439 0.858 rs8044367 chr16:88783374 A/G cg27087555 chr16:88793112 FAM38A -1.49 -14.34 -0.62 1.11e-36 Plateletcrit; LUSC cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg24450063 chr1:156163899 SLC25A44 1.06 17.27 0.69 3.28e-48 Testicular germ cell tumor; LUSC trans rs12458462 0.851 rs60298379 chr18:77488422 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.36 -0.33 6.7e-10 Monocyte count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08128228 chr1:167191360 POU2F1 -0.36 -6.43 -0.33 4.47e-10 Electrocardiographic conduction measures; LUSC cis rs9616064 0.506 rs6008944 chr22:47060976 C/T cg05621596 chr22:47072043 GRAMD4 -0.4 -6.56 -0.34 2.06e-10 Urate levels in obese individuals; LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.23 0.61 3e-36 Platelet count; LUSC cis rs1448094 0.872 rs7311150 chr12:86435989 A/T cg00310523 chr12:86230176 RASSF9 0.35 6.34 0.33 7.53e-10 Major depressive disorder; LUSC cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg15691649 chr6:25882328 NA -0.39 -6.37 -0.33 6.13e-10 Blood metabolite levels; LUSC cis rs12368653 0.641 rs12826708 chr12:58058373 G/A cg12615879 chr12:58013172 SLC26A10 0.37 8.46 0.42 8.33e-16 Multiple sclerosis; LUSC cis rs2439831 0.717 rs7165471 chr15:43644788 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs6496667 0.509 rs2253419 chr15:90945875 A/G cg10434728 chr15:90938212 IQGAP1 0.34 6.48 0.33 3.24e-10 Rheumatoid arthritis; LUSC cis rs17445774 1.000 rs17445774 chr2:200859249 A/G cg17644776 chr2:200775616 C2orf69 -0.45 -6.88 -0.35 3.05e-11 LDL cholesterol to HDL cholesterol ratio; LUSC cis rs7100689 0.646 rs7098045 chr10:82123856 G/C cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs2486288 0.656 rs1706768 chr15:45569443 T/C cg26924012 chr15:45694286 SPATA5L1 -0.75 -11.04 -0.52 2.39e-24 Glomerular filtration rate; LUSC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -6.52 -0.34 2.58e-10 Developmental language disorder (linguistic errors); LUSC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg03732007 chr1:2071316 PRKCZ -0.54 -9.76 -0.47 5.67e-20 Height; LUSC cis rs72781680 0.898 rs17462433 chr2:24012758 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs11626933 0.959 rs2149649 chr14:90774974 A/G cg14092571 chr14:90743983 NA 0.88 18.79 0.72 2.94e-54 Gut microbiota (bacterial taxa); LUSC cis rs2637266 1.000 rs7897061 chr10:78366776 C/T cg18941641 chr10:78392320 NA 0.4 7.24 0.37 3.05e-12 Pulmonary function; LUSC cis rs243505 1.000 rs243514 chr7:148427873 A/G cg09806900 chr7:148480153 CUL1 0.49 7.03 0.36 1.14e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.79 8.15 0.41 7.25e-15 Initial pursuit acceleration; LUSC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg00310523 chr12:86230176 RASSF9 -0.53 -10.23 -0.49 1.5e-21 Major depressive disorder; LUSC cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg14844989 chr11:31128820 NA -0.39 -6.02 -0.31 4.6e-9 Red blood cell count; LUSC cis rs73001065 0.901 rs8107974 chr19:19388500 A/T cg03709012 chr19:19516395 GATAD2A 0.84 6.26 0.32 1.17e-9 LDL cholesterol; LUSC cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg06784218 chr1:46089804 CCDC17 -0.5 -10.06 -0.48 5.91e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7216064 1.000 rs8082512 chr17:65837059 T/C cg12091567 chr17:66097778 LOC651250 -0.75 -9.36 -0.46 1.21e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7100689 0.646 rs4601708 chr10:82119583 G/T cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.28 0.32 1.08e-9 Tonsillectomy; LUSC cis rs7267979 1.000 rs6050590 chr20:25384994 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -19.99 -0.74 4.99e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs9419702 0.538 rs9419625 chr10:133534954 T/G cg23460707 chr10:133558971 NA 0.36 6.2 0.32 1.67e-9 Survival in rectal cancer; LUSC cis rs6060960 0.502 rs15817 chr20:30193538 A/G cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.2e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg26314531 chr2:26401878 FAM59B -0.69 -9.39 -0.46 9.76e-19 Gut microbiome composition (summer); LUSC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg19717773 chr7:2847554 GNA12 -0.33 -5.69 -0.3 2.77e-8 Height; LUSC cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg24642439 chr20:33292090 TP53INP2 0.48 7.2 0.37 3.89e-12 Glomerular filtration rate (creatinine); LUSC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg12963246 chr6:28129442 ZNF389 0.43 5.92 0.31 8.05e-9 Depression; LUSC cis rs2806561 0.796 rs1738467 chr1:23506521 C/T cg12483005 chr1:23474871 LUZP1 0.4 6.16 0.32 2.04e-9 Height; LUSC cis rs9650657 0.812 rs7834466 chr8:10634805 G/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.2 -0.32 1.69e-9 Neuroticism; LUSC cis rs7927592 0.956 rs55816191 chr11:68262979 G/T cg01657329 chr11:68192670 LRP5 -0.45 -6.76 -0.35 6.35e-11 Total body bone mineral density; LUSC cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.43e-32 Chronic sinus infection; LUSC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg19592336 chr6:28129416 ZNF389 0.47 6.36 0.33 6.45e-10 Parkinson's disease; LUSC cis rs2404602 0.692 rs55676827 chr15:76961716 C/T cg26408565 chr15:76604113 ETFA -0.47 -7.5 -0.38 5.79e-13 Blood metabolite levels; LUSC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs12478296 1.000 rs55777943 chr2:243040686 T/C cg06360820 chr2:242988706 NA -0.9 -9.86 -0.47 2.7e-20 Obesity-related traits; LUSC cis rs2559856 1.000 rs2251187 chr12:102081889 G/A cg12924262 chr12:102091054 CHPT1 0.43 5.85 0.3 1.18e-8 Blood protein levels; LUSC cis rs6695223 0.571 rs4907133 chr1:85538947 A/G cg22153463 chr1:85462885 MCOLN2 -0.66 -7.55 -0.38 4.32e-13 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs3768617 0.528 rs6672093 chr1:183079853 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.9 0.51 7.26e-24 Fuchs's corneal dystrophy; LUSC cis rs3806843 0.576 rs246041 chr5:140331128 C/G cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg01689657 chr7:91764605 CYP51A1 0.33 5.97 0.31 6.12e-9 Breast cancer; LUSC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg26408565 chr15:76604113 ETFA -0.49 -7.88 -0.4 4.81e-14 Blood metabolite levels; LUSC cis rs2996428 0.667 rs11578581 chr1:3770642 G/A cg13057898 chr1:3703894 LRRC47 0.49 8.66 0.43 2.02e-16 Red cell distribution width; LUSC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg12365402 chr11:9010492 NRIP3 -0.49 -9.44 -0.46 6.86e-19 Hemoglobin concentration; LUSC cis rs7953249 0.656 rs6489786 chr12:121397875 A/G cg02403541 chr12:121454288 C12orf43 -0.73 -11.24 -0.52 4.35e-25 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs11153306 0.791 rs9387017 chr6:111944006 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.52 -0.34 2.54e-10 Tonsillectomy; LUSC cis rs238295 0.805 rs6076852 chr20:5544502 A/G cg15842884 chr20:5591925 RP5-1022P6.2 0.44 5.91 0.31 8.33e-9 Occipital cortical area (total cortical area interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05470666 chr10:74856828 P4HA1 -0.43 -6.38 -0.33 5.96e-10 Electrocardiographic conduction measures; LUSC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg13119609 chr19:45449297 APOC2 0.51 10.16 0.49 2.67e-21 Blood protein levels; LUSC cis rs1371867 0.875 rs1660344 chr8:101324659 A/G cg00191853 chr8:101177733 SPAG1 -0.4 -6.37 -0.33 6.42e-10 Atrioventricular conduction; LUSC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg22800045 chr5:56110881 MAP3K1 0.46 6.56 0.34 2.1e-10 Coronary artery disease; LUSC cis rs7100689 0.784 rs7078075 chr10:82162768 A/G cg00277334 chr10:82204260 NA -0.53 -7.17 -0.37 4.8e-12 Post bronchodilator FEV1; LUSC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00934597 chr7:893267 UNC84A 0.47 7.07 0.36 9.13e-12 Perceived unattractiveness to mosquitoes; LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg14893161 chr1:205819251 PM20D1 0.5 7.31 0.37 2e-12 Menarche (age at onset); LUSC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg25019033 chr10:957182 NA -0.52 -6.48 -0.33 3.29e-10 Eosinophil percentage of granulocytes; LUSC cis rs7584330 0.554 rs116656801 chr2:238431257 A/G cg16989719 chr2:238392110 NA -0.4 -5.73 -0.3 2.21e-8 Prostate cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08567662 chr2:176867156 KIAA1715 -0.47 -7.13 -0.36 6.38e-12 Electrocardiographic conduction measures; LUSC cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg26647111 chr11:31128758 NA -0.42 -6.03 -0.31 4.23e-9 Red blood cell count; LUSC cis rs9322193 0.886 rs4870049 chr6:150158194 G/T cg07701084 chr6:150067640 NUP43 0.54 8.09 0.4 1.09e-14 Lung cancer; LUSC cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.58 -0.43 3.59e-16 Schizophrenia; LUSC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg09021430 chr5:549028 NA -0.56 -8.61 -0.43 2.87e-16 Lung disease severity in cystic fibrosis; LUSC trans rs61931739 0.534 rs1705757 chr12:34091637 A/G cg13010199 chr12:38710504 ALG10B 0.54 8.05 0.4 1.48e-14 Morning vs. evening chronotype; LUSC cis rs6815814 0.950 rs5743556 chr4:38806851 A/G cg02016764 chr4:38805732 TLR1 -0.54 -5.92 -0.31 7.93e-9 Breast cancer; LUSC cis rs11229555 0.645 rs7116007 chr11:58218701 C/T cg15696309 chr11:58395628 NA -0.68 -8.26 -0.41 3.34e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs11098499 0.866 rs12499602 chr4:120284387 T/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg23029597 chr12:123009494 RSRC2 -0.74 -9.14 -0.45 6.4e-18 Body mass index; LUSC cis rs2115536 1.000 rs11072871 chr15:80197931 T/C cg00225070 chr15:80189496 MTHFS 0.63 9.7 0.47 9.03e-20 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg18876405 chr7:65276391 NA 0.77 13.41 0.59 4.13e-33 Aortic root size; LUSC cis rs748404 0.578 rs478028 chr15:43610772 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.61 9.46 0.46 5.61e-19 Lung cancer; LUSC cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg26384229 chr12:38710491 ALG10B 0.9 15.19 0.64 5.67e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs1775715 0.835 rs113450267 chr10:32223728 G/A cg18675610 chr10:32216311 ARHGAP12 0.29 6.28 0.32 1.08e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs11677416 1.000 rs1304037 chr2:113532236 C/T cg27083787 chr2:113543245 IL1A -0.46 -7.14 -0.36 5.83e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg12641515 chr19:46296257 DMWD 0.48 7.17 0.37 4.76e-12 Coronary artery disease; LUSC cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg08807101 chr21:30365312 RNF160 -0.66 -10.19 -0.49 2.03e-21 Pancreatic cancer; LUSC cis rs11190604 1.000 rs3750626 chr10:102266316 C/T cg16342193 chr10:102329863 NA -0.35 -6.2 -0.32 1.65e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs8099014 0.911 rs4940702 chr18:56110620 T/C cg12907477 chr18:56117327 MIR122 0.43 6.72 0.35 7.88e-11 Platelet count; LUSC cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg01028140 chr2:1542097 TPO -0.37 -6.04 -0.31 4.05e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs6987853 0.686 rs7818789 chr8:42354257 A/G cg09913449 chr8:42400586 C8orf40 0.42 7.18 0.37 4.44e-12 Mean corpuscular hemoglobin concentration; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs17102423 0.594 rs1953232 chr14:65570386 A/C cg11161011 chr14:65562177 MAX 0.71 11.02 0.52 2.68e-24 Obesity-related traits; LUSC cis rs7592578 0.882 rs58568707 chr2:191468987 G/A cg11845111 chr2:191398756 TMEM194B -0.86 -11.5 -0.53 5.35e-26 Diastolic blood pressure; LUSC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg00784671 chr22:46762841 CELSR1 -0.58 -6.85 -0.35 3.6e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg13256891 chr4:100009986 ADH5 0.51 6.89 0.35 2.74e-11 Smoking initiation; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27367093 chr11:72145746 CLPB -0.47 -6.14 -0.32 2.29e-9 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg05861140 chr6:150128134 PCMT1 -0.39 -5.89 -0.31 9.58e-9 Lung cancer; LUSC trans rs1908814 0.516 rs7812563 chr8:11794488 T/G cg08975724 chr8:8085496 FLJ10661 0.48 6.95 0.36 1.87e-11 Neuroticism; LUSC cis rs2404602 0.647 rs11634266 chr15:77093461 A/G cg23625390 chr15:77176239 SCAPER -0.64 -9.88 -0.48 2.35e-20 Blood metabolite levels; LUSC cis rs8017423 0.967 rs8022531 chr14:90729931 T/C cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg03929089 chr4:120376271 NA -0.95 -16.59 -0.67 1.64e-45 Height; LUSC cis rs950169 0.922 rs62021167 chr15:85118051 T/A cg17173187 chr15:85201210 NMB 0.36 6.45 0.33 3.99e-10 Schizophrenia; LUSC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg08493051 chr2:3487164 NA -0.53 -8.6 -0.43 3.11e-16 Neurofibrillary tangles; LUSC cis rs6424115 0.557 rs35904775 chr1:24180623 T/C cg15997130 chr1:24165203 NA -0.49 -8.05 -0.4 1.42e-14 Immature fraction of reticulocytes; LUSC cis rs7927592 0.913 rs11228287 chr11:68349754 A/G cg20283391 chr11:68216788 NA -0.61 -8.42 -0.42 1.15e-15 Total body bone mineral density; LUSC cis rs1728785 1.000 rs11647432 chr16:68565426 C/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs2625529 0.689 rs12898728 chr15:72112853 C/T cg16672083 chr15:72433130 SENP8 -0.47 -7.65 -0.39 2.14e-13 Red blood cell count; LUSC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.67 11.55 0.53 3.31e-26 Personality dimensions; LUSC cis rs6754311 0.773 rs309180 chr2:136614255 A/G cg07169764 chr2:136633963 MCM6 0.58 7.68 0.39 1.74e-13 Mosquito bite size; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.61 0.57 4.22e-30 Prudent dietary pattern; LUSC cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.45 0.33 3.85e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9467773 0.935 rs11752946 chr6:26560364 C/A cg11502198 chr6:26597334 ABT1 0.59 8.93 0.44 2.98e-17 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs9376077 chr6:135299713 C/G cg24558204 chr6:135376177 HBS1L 0.59 8.97 0.44 2.15e-17 Red blood cell count; LUSC cis rs8014204 0.901 rs6574200 chr14:75364451 C/T cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.44 -0.53 8.44e-26 Caffeine consumption; LUSC cis rs11785400 0.793 rs4736367 chr8:143742477 G/A cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg11244672 chr19:19639970 YJEFN3 -0.58 -7.38 -0.37 1.27e-12 Bipolar disorder; LUSC cis rs8141529 0.509 rs5762864 chr22:29253364 T/C cg15103426 chr22:29168792 CCDC117 0.49 6.25 0.32 1.24e-9 Lymphocyte counts; LUSC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg18876405 chr7:65276391 NA 0.55 8.8 0.43 7.72e-17 Aortic root size; LUSC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg22800045 chr5:56110881 MAP3K1 0.59 7.94 0.4 3.1e-14 Coronary artery disease; LUSC cis rs7615316 0.872 rs7630130 chr3:142240934 G/C cg16271453 chr3:142027066 XRN1 -0.4 -6.83 -0.35 3.93e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9788682 0.947 rs7169584 chr15:78822660 A/T cg18825076 chr15:78729989 IREB2 0.47 6.17 0.32 1.96e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7828089 0.542 rs7332050 chr8:22265294 G/T cg12081754 chr8:22256438 SLC39A14 0.69 10.69 0.5 3.98e-23 Verbal declarative memory; LUSC trans rs488628 1.000 rs542459 chr3:118138927 T/C cg06621744 chr14:37052470 NKX2-8 -0.28 -6.28 -0.32 1.07e-9 White matter integrity (bipolar disorder risk interaction); LUSC cis rs997295 0.713 rs9302246 chr15:68021280 A/G cg08079166 chr15:68083412 MAP2K5 -0.34 -6.67 -0.34 1.07e-10 Motion sickness; LUSC cis rs4704187 0.687 rs4360021 chr5:74421962 A/G cg03227963 chr5:74354835 NA 0.32 6.9 0.35 2.6e-11 Response to amphetamines; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08370718 chr15:49913307 DTWD1;C15orf33 -0.52 -6.6 -0.34 1.66e-10 Bipolar disorder and schizophrenia; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg16031515 chr1:205743344 RAB7L1 -0.29 -6.14 -0.32 2.35e-9 Menarche (age at onset); LUSC trans rs3733585 0.673 rs4407505 chr4:9953367 T/G cg26043149 chr18:55253948 FECH -0.45 -6.9 -0.35 2.59e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs6601327 0.635 rs10099122 chr8:9568003 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.29 -0.33 9.74e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs4595586 0.545 rs6580896 chr12:39372223 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs1549118 0.560 rs11848126 chr14:78318268 T/C cg23188588 chr14:78226832 SNW1;C14orf178 -0.41 -5.65 -0.3 3.38e-8 Resting heart rate; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07134292 chr1:51702069 RNF11 -0.42 -6.6 -0.34 1.61e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg22963979 chr7:1858916 MAD1L1 -0.47 -7.18 -0.37 4.62e-12 Bipolar disorder and schizophrenia; LUSC cis rs72925845 0.525 rs72907478 chr17:76431015 C/T cg03830375 chr17:76426088 DNAH17 0.52 6.02 0.31 4.6e-9 Triglycerides; LUSC cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg05347473 chr6:146136440 FBXO30 0.48 7.89 0.4 4.3e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs17604090 1.000 rs28420551 chr7:29685353 G/A cg19413766 chr7:29689036 LOC646762 -0.58 -6.93 -0.35 2.12e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs11122272 0.701 rs2486725 chr1:231540288 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.3 -0.49 8.36e-22 Hemoglobin concentration; LUSC cis rs10789491 0.588 rs2099766 chr1:47193987 T/C cg15501359 chr1:47185051 KIAA0494 0.71 9.17 0.45 5.06e-18 Response to hepatitis C treatment; LUSC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg03517284 chr6:25882590 NA -0.55 -9.23 -0.45 3.18e-18 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.94 0.31 7.02e-9 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg01579765 chr21:45077557 HSF2BP -0.46 -9.62 -0.47 1.65e-19 Mean corpuscular volume; LUSC trans rs4714291 0.832 rs6917417 chr6:40104628 T/C cg02267698 chr19:7991119 CTXN1 -0.52 -7.79 -0.39 8.3e-14 Strep throat; LUSC cis rs9747201 1.000 rs58119191 chr17:80155329 T/C cg18209359 chr17:80159595 CCDC57 -0.39 -6.66 -0.34 1.15e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6456156 0.586 rs13208636 chr6:167461965 T/G cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC cis rs7607369 0.637 rs17462630 chr2:219286541 C/G cg02176678 chr2:219576539 TTLL4 -0.67 -10.95 -0.51 4.71e-24 Red blood cell count;Amyotrophic lateral sclerosis; LUSC trans rs10090774 0.965 rs11167007 chr8:141918181 G/C cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 5.99 0.31 5.4e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs61931739 0.517 rs34760282 chr12:34153711 G/T cg13010199 chr12:38710504 ALG10B 0.54 8.43 0.42 1.05e-15 Morning vs. evening chronotype; LUSC trans rs4674124 1.000 rs10181822 chr2:217761683 G/T cg18563886 chr10:135203102 PAOX 0.45 6.24 0.32 1.31e-9 Breast cancer; LUSC cis rs400736 0.562 rs12129505 chr1:8171734 T/C cg25007680 chr1:8021821 PARK7 -0.48 -7.0 -0.36 1.38e-11 Response to antidepressants and depression; LUSC cis rs5770917 1.000 rs2073604 chr22:51008925 G/A cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.6 -5.75 -0.3 2.05e-8 Narcolepsy; LUSC cis rs7465272 1.000 rs35476574 chr8:143683784 C/A cg10104451 chr8:143696006 ARC -0.64 -8.99 -0.44 1.86e-17 Bipolar disorder and schizophrenia; LUSC cis rs10144321 0.644 rs10144242 chr14:100794404 C/T cg14882082 chr14:100845427 WDR25 -0.41 -7.18 -0.37 4.66e-12 Menarche (age at onset); LUSC cis rs11155671 0.530 rs4870080 chr6:150202644 T/C cg07701084 chr6:150067640 NUP43 0.47 7.13 0.36 6.29e-12 Testicular germ cell tumor; LUSC cis rs7760949 0.963 rs4142889 chr6:13918461 T/A cg27413430 chr6:13925136 RNF182 0.54 8.01 0.4 1.97e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs7095944 0.644 rs965484 chr10:126453481 T/C cg08799069 chr10:126477246 METTL10 -0.41 -6.31 -0.33 8.77e-10 Asthma; LUSC cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg06784218 chr1:46089804 CCDC17 -0.58 -11.36 -0.53 1.65e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs35883536 0.587 rs2809799 chr1:101036516 A/G cg09408571 chr1:101003634 GPR88 0.31 6.1 0.32 2.86e-9 Monocyte count; LUSC cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.51 7.49 0.38 6.2800000000000005e-13 Axial length; LUSC cis rs61931739 0.500 rs10844846 chr12:34394611 C/G cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC cis rs6700896 0.931 rs11809906 chr1:66115064 C/T cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs61931739 0.534 rs11053010 chr12:34093228 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs4631830 0.720 rs11004415 chr10:51498181 G/A cg16070123 chr10:51489643 NA 0.57 9.38 0.46 1.07e-18 Prostate-specific antigen levels; LUSC cis rs2668423 0.922 rs266805 chr19:1376723 C/T cg02639931 chr19:1387894 NDUFS7 -0.52 -8.89 -0.44 3.78e-17 Nonalcoholic fatty liver disease; LUSC cis rs61935443 0.832 rs11107771 chr12:95276844 A/G cg21533806 chr12:95267307 NA 0.53 6.65 0.34 1.19e-10 Schizophrenia; LUSC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11644478 chr21:40555479 PSMG1 -0.73 -13.2 -0.59 2.63e-32 Cognitive function; LUSC cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.21e-35 Breast cancer; LUSC cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg12615879 chr12:58013172 SLC26A10 -0.29 -6.11 -0.32 2.84e-9 Celiac disease or Rheumatoid arthritis; LUSC cis rs61612642 0.537 rs73434275 chr6:42156239 G/A cg10382835 chr6:42185730 MRPS10 0.68 6.53 0.34 2.52e-10 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs6669072 0.647 rs814546 chr1:91239355 G/T cg08895590 chr1:91227319 NA -0.36 -8.22 -0.41 4.47e-15 Cognitive function; LUSC cis rs11190604 1.000 rs2495752 chr10:102326115 T/C cg23241863 chr10:102295624 HIF1AN 0.5 5.71 0.3 2.53e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2860975 0.905 rs10786182 chr10:96789775 C/T cg09036531 chr10:96991505 NA -0.45 -6.33 -0.33 7.85e-10 Immune response to smallpox vaccine (IL-6); LUSC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg01879757 chr17:41196368 BRCA1 -0.46 -6.58 -0.34 1.86e-10 Menopause (age at onset); LUSC cis rs7577696 0.785 rs11683760 chr2:32364093 C/T cg02381751 chr2:32503542 YIPF4 -0.42 -5.81 -0.3 1.48e-8 Inflammatory biomarkers; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00834319 chr14:64970752 ZBTB25;ZBTB1 -0.42 -6.12 -0.32 2.64e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg07395648 chr5:131743802 NA -0.37 -5.66 -0.3 3.32e-8 Breast cancer; LUSC cis rs7777754 0.512 rs11238131 chr7:50538589 T/C cg18232548 chr7:50535776 DDC -0.71 -11.09 -0.52 1.58e-24 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg22903471 chr2:27725779 GCKR -0.39 -6.69 -0.34 9.58e-11 Total body bone mineral density; LUSC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs68170813 0.641 rs6979368 chr7:107089009 C/G cg02696742 chr7:106810147 HBP1 -0.66 -9.66 -0.47 1.21e-19 Coronary artery disease; LUSC cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg22852734 chr6:133119734 C6orf192 1.12 13.82 0.6 1.17e-34 Type 2 diabetes nephropathy; LUSC cis rs12701220 0.817 rs7798459 chr7:1087965 C/T cg04025307 chr7:1156635 C7orf50 0.44 5.95 0.31 6.78e-9 Bronchopulmonary dysplasia; LUSC cis rs7605827 0.930 rs1997307 chr2:15512588 T/C cg19274914 chr2:15703543 NA 0.46 8.89 0.44 3.98e-17 Educational attainment (years of education); LUSC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg06634786 chr22:41940651 POLR3H -0.49 -6.14 -0.32 2.38e-9 Vitiligo; LUSC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.11 -0.32 2.8e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2742234 0.955 rs2503841 chr10:43675721 C/T cg15436174 chr10:43711423 RASGEF1A -0.34 -6.29 -0.33 9.75e-10 Hirschsprung disease; LUSC cis rs9300255 0.602 rs6488864 chr12:123618362 G/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.4 -5.9 -0.31 9.11e-9 Neutrophil percentage of white cells; LUSC cis rs7296418 0.961 rs1790122 chr12:123606739 G/A cg05973401 chr12:123451056 ABCB9 0.62 8.94 0.44 2.65e-17 Platelet count; LUSC cis rs2985684 0.841 rs7158577 chr14:50058633 C/T cg04989706 chr14:50066350 PPIL5 -0.48 -6.26 -0.32 1.16e-9 Carotid intima media thickness; LUSC cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Alcohol dependence; LUSC trans rs6502050 0.835 rs7503225 chr17:80099639 C/A cg07393940 chr7:158741817 NA 0.36 6.57 0.34 1.98e-10 Life satisfaction; LUSC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg03732007 chr1:2071316 PRKCZ -0.53 -9.36 -0.46 1.21e-18 Height; LUSC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg18252515 chr7:66147081 NA -1.2 -13.78 -0.6 1.67e-34 Diabetic kidney disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01073178 chr12:117537710 TESC 0.48 8.81 0.43 6.84e-17 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg07701084 chr6:150067640 NUP43 0.55 8.29 0.41 2.84e-15 Lung cancer; LUSC cis rs36093844 0.800 rs76663264 chr11:85578455 C/G cg25872744 chr11:85566296 CCDC83 -0.45 -5.88 -0.31 9.88e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs3126085 0.935 rs7531094 chr1:152176850 A/G cg26876637 chr1:152193138 HRNR 0.45 6.61 0.34 1.54e-10 Atopic dermatitis; LUSC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg02269571 chr22:50332266 NA -0.57 -8.57 -0.42 3.92e-16 Schizophrenia; LUSC cis rs870825 0.932 rs2696059 chr4:185575127 A/T cg04058563 chr4:185651563 MLF1IP -0.83 -11.36 -0.53 1.71e-25 Blood protein levels; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC trans rs10432489 0.708 rs10189224 chr2:181764318 A/C cg09897338 chr1:211849090 NEK2 -0.83 -6.1 -0.32 2.87e-9 QT interval; LUSC cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.87 0.35 3.22e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs2980439 0.557 rs2976876 chr8:8318850 T/C cg11608241 chr8:8085544 FLJ10661 0.42 6.27 0.32 1.14e-9 Neuroticism; LUSC cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg13256891 chr4:100009986 ADH5 -0.44 -6.09 -0.32 3.05e-9 Alcohol dependence; LUSC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg18240062 chr17:79603768 NPLOC4 0.7 13.1 0.58 6.19e-32 Eye color traits; LUSC cis rs10248839 0.518 rs1317741 chr7:29711149 T/C cg19413766 chr7:29689036 LOC646762 -0.54 -7.33 -0.37 1.75e-12 Facial emotion recognition (angry faces); LUSC cis rs2658782 0.951 rs2608214 chr11:93148665 C/T cg15737290 chr11:93063684 CCDC67 0.64 8.12 0.41 9.11e-15 Pulmonary function decline; LUSC cis rs2637266 1.000 rs7896831 chr10:78366649 A/T cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg20476274 chr7:133979776 SLC35B4 0.87 16.7 0.67 6.08e-46 Mean platelet volume; LUSC cis rs2404602 0.647 rs11629727 chr15:77009038 G/C cg23625390 chr15:77176239 SCAPER -0.67 -10.04 -0.48 6.78e-21 Blood metabolite levels; LUSC cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg12311346 chr5:56204834 C5orf35 0.96 13.5 0.59 1.85e-33 Initial pursuit acceleration; LUSC cis rs4834770 1.000 rs6857641 chr4:120243511 T/C cg24375607 chr4:120327624 NA 0.41 5.84 0.3 1.26e-8 Blood protein levels; LUSC cis rs4930103 0.935 rs2071095 chr11:2020627 C/A cg23202291 chr11:1979235 NA 0.39 6.1 0.32 2.96e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20114781 chr15:43622253 ADAL;LCMT2 0.75 6.04 0.31 4.02e-9 Cognitive performance; LUSC cis rs9311676 0.656 rs59643048 chr3:58390248 A/G cg26110898 chr3:58419937 PDHB 0.4 6.42 0.33 4.56e-10 Systemic lupus erythematosus; LUSC cis rs921943 0.957 rs6881725 chr5:78310754 T/C cg16405876 chr5:78317871 DMGDH 0.28 5.7 0.3 2.69e-8 Blood and toenail selenium levels;Blood trace element (Se levels); LUSC cis rs9311676 0.609 rs55797456 chr3:58378206 C/T cg26110898 chr3:58419937 PDHB 0.42 6.77 0.35 5.85e-11 Systemic lupus erythematosus; LUSC trans rs9409565 0.826 rs9409767 chr9:97228524 T/C cg05679027 chr9:99775184 HIATL2 -0.49 -7.04 -0.36 1.09e-11 Colorectal cancer (alcohol consumption interaction); LUSC cis rs709400 0.633 rs8013101 chr14:103951772 G/C cg10523860 chr14:103875565 MARK3 -0.37 -6.07 -0.32 3.42e-9 Body mass index; LUSC trans rs9393777 0.920 rs35716472 chr6:27406607 C/G cg06606381 chr12:133084897 FBRSL1 -0.9 -8.79 -0.43 8e-17 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.564 rs11098507 chr4:120288286 G/A cg25214090 chr10:38739885 LOC399744 0.5 7.57 0.38 3.58e-13 Corneal astigmatism; LUSC cis rs9905704 0.918 rs304283 chr17:56785725 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.75 0.39 1.15e-13 Testicular germ cell tumor; LUSC cis rs6424115 0.867 rs10917431 chr1:24174093 T/G cg15997130 chr1:24165203 NA -0.52 -8.34 -0.42 1.99e-15 Immature fraction of reticulocytes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg15577575 chr1:145470249 ANKRD34A;POLR3GL -0.45 -6.04 -0.31 4.15e-9 Hepatitis; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg01238044 chr22:24384105 GSTT1 -0.62 -9.96 -0.48 1.23e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.82 -0.51 1.36e-23 Monocyte percentage of white cells; LUSC cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg23583168 chr7:148888333 NA -0.88 -16.85 -0.68 1.6e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.23e-8 Total body bone mineral density; LUSC cis rs6121246 0.567 rs6060344 chr20:30207316 A/G cg18721089 chr20:30220636 NA -0.37 -5.75 -0.3 2.05e-8 Mean corpuscular hemoglobin; LUSC cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg13736514 chr6:26305472 NA 0.46 8.96 0.44 2.37e-17 Educational attainment; LUSC cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg27087555 chr16:88793112 FAM38A -1.47 -12.53 -0.57 8.61e-30 Plateletcrit; LUSC cis rs344364 0.629 rs9806826 chr16:1894912 C/T cg00564555 chr16:1970112 NA -0.36 -6.39 -0.33 5.65e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs859767 0.704 rs1818614 chr2:135356351 A/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.18 -0.32 1.88e-9 Neuroticism; LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg22638593 chr5:131593259 PDLIM4 -0.48 -7.32 -0.37 1.88e-12 Acylcarnitine levels; LUSC cis rs10911251 0.528 rs10911264 chr1:183115040 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.64 0.5 5.92e-23 Colorectal cancer; LUSC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.07e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg22868518 chr11:507468 RNH1 -0.6 -5.92 -0.31 7.78e-9 Body mass index; LUSC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg03388025 chr16:89894329 SPIRE2 0.35 7.55 0.38 4.21e-13 Vitiligo; LUSC cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg05283184 chr6:79620031 NA -0.57 -11.82 -0.54 3.53e-27 Intelligence (multi-trait analysis); LUSC cis rs7532866 0.885 rs7517224 chr1:26731029 A/G cg17456097 chr1:26900765 RPS6KA1 -0.42 -6.11 -0.32 2.85e-9 Height; LUSC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg21880101 chr17:80066754 CCDC57 -0.3 -5.72 -0.3 2.37e-8 Life satisfaction; LUSC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg18240062 chr17:79603768 NPLOC4 0.61 10.28 0.49 1e-21 Eye color traits; LUSC cis rs10927875 0.632 rs904911 chr1:16126932 C/T cg21385522 chr1:16154831 NA -0.98 -18.47 -0.71 5.65e-53 Dilated cardiomyopathy; LUSC cis rs698813 0.674 rs6544753 chr2:44501895 A/T cg00619915 chr2:44497795 NA -0.53 -7.18 -0.37 4.66e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg18876405 chr7:65276391 NA 0.58 9.41 0.46 8.25e-19 Aortic root size; LUSC cis rs10089 1.000 rs10089 chr5:127522543 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 10.76 0.51 2.24e-23 Ileal carcinoids; LUSC cis rs270601 0.721 rs162894 chr5:131611872 T/G cg12564285 chr5:131593104 PDLIM4 0.53 9.71 0.47 8.21e-20 Acylcarnitine levels; LUSC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -6.84 -0.35 3.79e-11 Developmental language disorder (linguistic errors); LUSC cis rs68170813 0.523 rs7781947 chr7:106902219 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs295140 0.605 rs3769471 chr2:201195403 G/A cg04283868 chr2:201171347 SPATS2L 0.41 6.03 0.31 4.41e-9 QT interval; LUSC cis rs17345786 0.906 rs72946021 chr3:101250008 T/G cg12386194 chr3:101231763 SENP7 0.63 8.61 0.43 2.85e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1790761 0.667 rs658768 chr11:67337808 G/A cg00290607 chr11:67383545 NA 0.37 6.88 0.35 3.04e-11 Mean corpuscular volume; LUSC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg25036284 chr2:26402008 FAM59B -0.68 -9.38 -0.46 1.06e-18 Gut microbiome composition (summer); LUSC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -12.01 -0.55 7.05e-28 Extrinsic epigenetic age acceleration; LUSC cis rs9399135 0.967 rs34546690 chr6:135369709 T/C cg22676075 chr6:135203613 NA 0.46 7.15 0.36 5.34e-12 Red blood cell count; LUSC cis rs10911251 0.528 rs10911255 chr1:183088868 G/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Colorectal cancer; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg26355072 chr5:141674679 NA -0.41 -6.76 -0.35 6.27e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.5 -0.38 5.79e-13 Personality dimensions; LUSC cis rs3008870 0.583 rs2031495 chr1:67421714 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.94 13.56 0.6 1.15e-33 Lymphocyte percentage of white cells; LUSC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.21 0.32 1.62e-9 Schizophrenia; LUSC cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.38 0.69 1.15e-48 Chronic sinus infection; LUSC trans rs2679649 1.000 rs2816128 chr6:122357203 G/A cg00167820 chr8:131663355 NA 0.54 6.33 0.33 8.12e-10 Subcutaneous adipose tissue; LUSC cis rs9611565 0.506 rs1883825 chr22:41703408 A/G cg03806693 chr22:41940476 POLR3H -0.61 -9.01 -0.44 1.62e-17 Vitiligo; LUSC cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.88 -0.51 8.54e-24 Chronic sinus infection; LUSC cis rs4285028 0.948 rs71329246 chr3:121680170 T/C cg11130432 chr3:121712080 ILDR1 -0.63 -9.59 -0.46 2.19e-19 Multiple sclerosis; LUSC trans rs72674100 1.000 rs10016964 chr4:97989089 T/C cg16405019 chr1:18959625 PAX7 -0.61 -6.44 -0.33 4.04e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg24060327 chr5:131705240 SLC22A5 -0.54 -8.89 -0.44 3.97e-17 Acylcarnitine levels; LUSC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.22 -0.32 1.52e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs8179 0.700 rs42040 chr7:92245927 C/T cg15732164 chr7:92237376 CDK6 -0.5 -6.87 -0.35 3.11e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs7188861 0.681 rs6498184 chr16:11435990 A/G cg00044050 chr16:11439710 C16orf75 -0.59 -6.47 -0.33 3.46e-10 HDL cholesterol; LUSC cis rs4363385 0.510 rs55959888 chr1:152913490 A/G cg00922841 chr1:152955080 SPRR1A -0.36 -5.91 -0.31 8.57e-9 Inflammatory skin disease; LUSC cis rs727505 0.954 rs989177 chr7:124412886 A/G cg23710748 chr7:124431027 NA -0.42 -7.53 -0.38 4.82e-13 Lewy body disease; LUSC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg00343986 chr7:65444356 GUSB 0.45 6.9 0.35 2.64e-11 Aortic root size; LUSC cis rs6121246 0.559 rs6060950 chr20:30378031 T/C cg13852791 chr20:30311386 BCL2L1 0.95 14.76 0.63 2.54e-38 Mean corpuscular hemoglobin; LUSC trans rs3942852 0.868 rs11039514 chr11:48109598 A/G cg03929089 chr4:120376271 NA -0.54 -6.15 -0.32 2.26e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs9341808 1.000 rs1359239 chr6:80956146 G/A cg08355045 chr6:80787529 NA 0.53 9.38 0.46 1.07e-18 Sitting height ratio; LUSC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg14552801 chr7:65878734 NA -0.37 -5.72 -0.3 2.36e-8 Aortic root size; LUSC cis rs9399135 0.967 rs12527683 chr6:135324534 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.01 0.44 1.65e-17 Red blood cell count; LUSC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg03517284 chr6:25882590 NA -0.42 -7.31 -0.37 1.94e-12 Intelligence (multi-trait analysis); LUSC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg19592336 chr6:28129416 ZNF389 -0.43 -6.01 -0.31 4.98e-9 Depression; LUSC trans rs61931739 0.500 rs12829125 chr12:34314789 A/G cg26384229 chr12:38710491 ALG10B 0.73 11.89 0.55 2.05e-27 Morning vs. evening chronotype; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg04267008 chr7:1944627 MAD1L1 -0.67 -10.53 -0.5 1.39e-22 Bipolar disorder and schizophrenia; LUSC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.74 7.4 0.38 1.14e-12 Initial pursuit acceleration; LUSC trans rs1486139 0.967 rs10229794 chr7:46295363 A/G cg17534202 chr9:96721102 NA -0.35 -6.3 -0.33 9.47e-10 Select biomarker traits; LUSC cis rs11166629 1.000 rs4909332 chr8:135646340 T/C cg21672855 chr8:135614777 ZFAT 0.35 5.65 0.3 3.46e-8 Smoking quantity; LUSC cis rs11608355 0.545 rs7969313 chr12:109907303 A/G cg05360138 chr12:110035743 NA 0.9 11.61 0.54 2.01e-26 Neuroticism; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg25192855 chr1:209979283 IRF6 0.33 7.01 0.36 1.36e-11 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs7677751 0.806 rs7689569 chr4:55096398 G/A cg17187183 chr4:55093834 PDGFRA 0.39 5.78 0.3 1.72e-8 Corneal astigmatism; LUSC cis rs17407555 0.601 rs73229828 chr4:10026833 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -6.24 -0.32 1.36e-9 Schizophrenia (age at onset); LUSC cis rs11676348 0.805 rs13007219 chr2:218963859 C/A cg00012203 chr2:219082015 ARPC2 -0.54 -8.44 -0.42 9.63e-16 Ulcerative colitis; LUSC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 13.26 0.59 1.56e-32 Platelet count; LUSC cis rs6138458 1.000 rs227621 chr20:24910528 A/C cg26195577 chr20:24973756 C20orf3 1.12 18.1 0.7 1.58e-51 Blood protein levels; LUSC cis rs7191700 0.836 rs10163410 chr16:11430615 G/C cg00044050 chr16:11439710 C16orf75 0.57 8.34 0.42 1.98e-15 Multiple sclerosis; LUSC cis rs735539 1.000 rs6490604 chr13:21284828 A/G cg04906043 chr13:21280425 IL17D -0.47 -8.54 -0.42 4.75e-16 Dental caries; LUSC cis rs6076065 0.683 rs2424556 chr20:23419556 C/T cg11657817 chr20:23433608 CST11 0.41 7.45 0.38 7.97e-13 Facial morphology (factor 15, philtrum width); LUSC cis rs868036 0.718 rs28463100 chr15:68078769 T/C cg05925327 chr15:68127851 NA -0.43 -6.95 -0.36 1.91e-11 Restless legs syndrome; LUSC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg24110177 chr3:50126178 RBM5 0.65 11.69 0.54 1.1e-26 Body mass index; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.54 -8.24 -0.41 4.05e-15 Lymphocyte counts; LUSC cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.69 -0.3 2.75e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs17407555 0.697 rs73212840 chr4:10087458 C/T cg11266682 chr4:10021025 SLC2A9 -0.45 -5.91 -0.31 8.4e-9 Schizophrenia (age at onset); LUSC trans rs853679 1.000 rs1679732 chr6:28221264 G/A cg01620082 chr3:125678407 NA 0.51 5.99 0.31 5.49e-9 Depression; LUSC trans rs28735056 0.875 rs62103176 chr18:77623611 G/C cg05926928 chr17:57297772 GDPD1 0.51 7.2 0.37 4.04e-12 Schizophrenia; LUSC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg15352829 chr14:105391018 PLD4 -0.39 -8.08 -0.4 1.2e-14 Rheumatoid arthritis; LUSC cis rs7177699 0.557 rs7165902 chr15:79115872 T/G cg00540400 chr15:79124168 NA 0.46 8.1 0.41 1.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg17633681 chr16:88106987 BANP -0.45 -8.04 -0.4 1.52e-14 Menopause (age at onset); LUSC cis rs926938 0.527 rs360672 chr1:115483836 C/T cg12756093 chr1:115239321 AMPD1 0.47 7.19 0.37 4.19e-12 Autism; LUSC trans rs1814175 0.935 rs1827017 chr11:49632592 C/G cg03929089 chr4:120376271 NA -0.98 -17.61 -0.69 1.48e-49 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14731413 chr10:52833444 PRKG1 -0.34 -5.96 -0.31 6.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs61931739 0.583 rs1873011 chr12:33752808 T/C cg26384229 chr12:38710491 ALG10B 0.44 6.38 0.33 5.95e-10 Morning vs. evening chronotype; LUSC cis rs1385374 0.858 rs34888374 chr12:129296536 G/A cg09035930 chr12:129282057 SLC15A4 -0.64 -6.8 -0.35 4.96e-11 Systemic lupus erythematosus; LUSC cis rs765787 0.530 rs2899381 chr15:45529630 C/T cg24006582 chr15:45444508 DUOX1 -0.6 -8.88 -0.44 4.09e-17 Uric acid levels; LUSC cis rs4474465 1.000 rs4945277 chr11:78166967 C/T cg27205649 chr11:78285834 NARS2 -0.49 -5.8 -0.3 1.53e-8 Alzheimer's disease (survival time); LUSC cis rs16866061 1.000 rs17480230 chr2:225399864 G/A cg12698349 chr2:225449008 CUL3 0.87 14.4 0.62 6.61e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs1775715 0.707 rs2808081 chr10:32162342 C/T cg04359828 chr10:32216031 ARHGAP12 -0.35 -6.05 -0.31 3.95e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg10523860 chr14:103875565 MARK3 -0.36 -5.67 -0.3 3.08e-8 Body mass index; LUSC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg14829155 chr15:31115871 NA -0.57 -7.93 -0.4 3.23e-14 Huntington's disease progression; LUSC trans rs9951602 0.541 rs56882694 chr18:76647010 C/T cg02800362 chr5:177631904 HNRNPAB 0.87 12.85 0.58 5.63e-31 Obesity-related traits; LUSC trans rs7939886 0.920 rs7112815 chr11:55960104 T/C cg03929089 chr4:120376271 NA 0.82 6.22 0.32 1.53e-9 Myopia (pathological); LUSC cis rs6754311 0.731 rs2236783 chr2:136594158 G/A cg07169764 chr2:136633963 MCM6 -0.61 -8.02 -0.4 1.82e-14 Mosquito bite size; LUSC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs11252926 0.931 rs12355162 chr10:563472 G/A cg18196295 chr10:418757 DIP2C -0.42 -6.38 -0.33 6.03e-10 Psychosis in Alzheimer's disease; LUSC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg11890956 chr21:40555474 PSMG1 -0.71 -10.78 -0.51 1.91e-23 Menarche (age at onset); LUSC cis rs11098499 0.954 rs10017543 chr4:120321420 G/A cg09307838 chr4:120376055 NA 0.78 11.21 0.52 5.63e-25 Corneal astigmatism; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg14092988 chr3:52407081 DNAH1 0.31 6.12 0.32 2.57e-9 Bipolar disorder; LUSC cis rs11122272 0.735 rs2749708 chr1:231529610 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.25 -0.49 1.28e-21 Hemoglobin concentration; LUSC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg21724239 chr8:58056113 NA 0.83 9.77 0.47 5.21e-20 Developmental language disorder (linguistic errors); LUSC cis rs61931739 0.500 rs34418276 chr12:34535976 C/T cg06521331 chr12:34319734 NA -0.43 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype; LUSC cis rs911119 0.955 rs6048946 chr20:23602307 G/T cg16589663 chr20:23618590 CST3 0.59 7.08 0.36 8.56e-12 Chronic kidney disease; LUSC cis rs599083 0.569 rs685095 chr11:68170376 C/T cg01657329 chr11:68192670 LRP5 0.48 6.35 0.33 7.17e-10 Bone mineral density (spine); LUSC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg12863693 chr15:85201151 NMB 0.35 6.88 0.35 3.05e-11 Schizophrenia; LUSC cis rs394563 1.000 rs394563 chr6:149797014 T/G cg11245181 chr6:149772854 ZC3H12D -0.29 -6.31 -0.33 8.79e-10 Dupuytren's disease; LUSC cis rs936229 0.871 rs2290574 chr15:75135447 T/C cg14664628 chr15:75095509 CSK -0.9 -14.04 -0.61 1.6e-35 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7917772 0.582 rs7906115 chr10:104327164 A/G cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34779708 0.931 rs13376871 chr10:35369056 A/G cg04310649 chr10:35416472 CREM -0.41 -6.54 -0.34 2.32e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2658782 0.951 rs72972357 chr11:93118840 T/C cg15737290 chr11:93063684 CCDC67 -0.59 -7.05 -0.36 1.03e-11 Pulmonary function decline; LUSC trans rs853679 0.607 rs28360499 chr6:27945396 G/A cg01620082 chr3:125678407 NA -0.8 -7.24 -0.37 3.11e-12 Depression; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg16606324 chr3:10149918 C3orf24 -0.58 -7.94 -0.4 3.03e-14 Alzheimer's disease; LUSC cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg07424592 chr7:64974309 NA 0.7 6.2 0.32 1.67e-9 Diabetic kidney disease; LUSC trans rs853679 0.882 rs9468300 chr6:28126840 C/T cg01620082 chr3:125678407 NA -0.6 -6.63 -0.34 1.34e-10 Depression; LUSC cis rs7917772 0.582 rs4408249 chr10:104374653 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.87 0.51 9.1e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs68170813 0.652 rs79295036 chr7:107193669 C/A cg02696742 chr7:106810147 HBP1 -0.64 -8.58 -0.42 3.72e-16 Coronary artery disease; LUSC cis rs2797160 0.547 rs1418645 chr6:125946476 T/A cg05901451 chr6:126070800 HEY2 -0.43 -6.08 -0.32 3.24e-9 Endometrial cancer; LUSC cis rs67072384 0.748 rs6592484 chr11:72464470 C/T cg04827223 chr11:72435913 ARAP1 -0.73 -6.35 -0.33 7.13e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg14383238 chr14:77647983 TMEM63C 0.51 6.35 0.33 6.85e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2692947 0.644 rs772154 chr2:97021664 G/T cg23100626 chr2:96804247 ASTL 0.27 6.43 0.33 4.46e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs701145 0.585 rs357476 chr3:153892844 A/G cg17054900 chr3:154042577 DHX36 -0.7 -7.14 -0.36 5.94e-12 Coronary artery disease; LUSC cis rs17253792 0.822 rs77408754 chr14:56082047 C/T cg01858014 chr14:56050164 KTN1 -0.79 -6.27 -0.32 1.08e-9 Putamen volume; LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.33e-19 Menopause (age at onset); LUSC cis rs8062405 0.755 rs4788080 chr16:28558081 C/T cg07382826 chr16:28625726 SULT1A1 0.28 5.81 0.3 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 16.97 0.68 5.24e-47 Gut microbiome composition (summer); LUSC trans rs7824557 0.592 rs920044 chr8:11224313 C/T cg15556689 chr8:8085844 FLJ10661 0.47 6.9 0.35 2.66e-11 Retinal vascular caliber; LUSC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg06022373 chr22:39101656 GTPBP1 0.89 14.69 0.63 4.85e-38 Menopause (age at onset); LUSC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg22437258 chr11:111473054 SIK2 -0.48 -6.2 -0.32 1.65e-9 Primary sclerosing cholangitis; LUSC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.92 0.35 2.25e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6433857 0.534 rs1157535 chr2:181361736 T/A cg23363182 chr2:181467187 NA -0.44 -7.16 -0.36 5.15e-12 Body mass index; LUSC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg05340658 chr4:99064831 C4orf37 -0.66 -11.47 -0.53 6.81e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs453301 0.686 rs10217044 chr8:8894752 A/G cg15556689 chr8:8085844 FLJ10661 -0.61 -9.88 -0.48 2.32e-20 Joint mobility (Beighton score); LUSC cis rs4660261 0.526 rs2485997 chr1:44345841 G/C cg15962314 chr1:44399869 ARTN 0.27 6.49 0.33 3.16e-10 Intelligence (multi-trait analysis); LUSC cis rs61774743 0.681 rs10889959 chr1:41849735 T/C cg08462924 chr1:41848221 NA 0.47 7.93 0.4 3.33e-14 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs7520050 0.966 rs946529 chr1:46485548 G/T cg06784218 chr1:46089804 CCDC17 -0.29 -5.67 -0.3 3.13e-8 Red blood cell count;Reticulocyte count; LUSC cis rs9302635 0.513 rs7184169 chr16:72152933 C/T cg01557791 chr16:72042693 DHODH -0.49 -6.28 -0.33 1.04e-9 Blood protein levels; LUSC cis rs1577917 1.000 rs2812972 chr6:86669880 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.35 -0.42 1.8e-15 Response to antipsychotic treatment; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02978827 chr13:48877687 RB1 0.51 7.02 0.36 1.26e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg16615211 chr3:44902933 MIR564;TMEM42 0.36 6.3 0.33 9.37e-10 Depressive symptoms; LUSC cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs881375 0.967 rs876445 chr9:123677102 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 6.94 0.36 2.04e-11 Rheumatoid arthritis; LUSC cis rs4423214 0.625 rs78685409 chr11:71137383 T/C cg05163923 chr11:71159392 DHCR7 -0.66 -8.52 -0.42 5.58e-16 Vitamin D levels; LUSC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg03929089 chr4:120376271 NA -1.03 -20.09 -0.74 2.01e-59 Height; LUSC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg05425664 chr17:57184151 TRIM37 -0.56 -8.27 -0.41 3.14e-15 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 2.88e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6693567 0.586 rs9661040 chr1:150483236 A/C cg15654264 chr1:150340011 RPRD2 0.44 7.04 0.36 1.1e-11 Migraine; LUSC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg25319279 chr11:5960081 NA -0.41 -5.79 -0.3 1.64e-8 DNA methylation (variation); LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.68 0.39 1.72e-13 Prudent dietary pattern; LUSC cis rs7607369 0.580 rs17573724 chr2:219652141 T/A cg02176678 chr2:219576539 TTLL4 -0.67 -13.25 -0.59 1.7e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs77633900 0.614 rs2170998 chr15:77007159 C/T cg21673338 chr15:77095150 SCAPER 0.73 7.9 0.4 3.95e-14 Non-glioblastoma glioma;Glioma; LUSC cis rs559928 0.556 rs734762 chr11:63912189 G/C cg05555928 chr11:63887634 MACROD1 -0.48 -6.09 -0.32 3.08e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2749592 0.918 rs4934590 chr10:37877569 T/C cg25427524 chr10:38739819 LOC399744 0.46 6.31 0.33 8.73e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg13798780 chr7:105162888 PUS7 0.56 6.04 0.31 4.04e-9 Bipolar disorder (body mass index interaction); LUSC trans rs61931739 0.534 rs11053075 chr12:34207009 A/G cg26384229 chr12:38710491 ALG10B -0.73 -12.05 -0.55 5.24e-28 Morning vs. evening chronotype; LUSC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg01416388 chr22:39784598 NA -0.39 -5.9 -0.31 8.75e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs10752881 0.505 rs35855069 chr1:183115341 A/C ch.1.3577855R chr1:183094577 LAMC1 0.68 10.32 0.49 7.22e-22 Colorectal cancer; LUSC cis rs11098499 0.780 rs12504773 chr4:120562149 G/C cg24375607 chr4:120327624 NA 0.75 10.86 0.51 1.01e-23 Corneal astigmatism; LUSC trans rs11989744 0.500 rs7844903 chr8:23568464 T/C cg03492747 chr16:86543808 FOXF1 -0.66 -11.48 -0.53 6.29e-26 Waist-hip ratio; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg04155289 chr7:94953770 PON1 0.47 9.51 0.46 3.82e-19 Paraoxonase activity; LUSC cis rs2386661 0.591 rs11255051 chr10:5653450 A/G cg12223502 chr10:5658492 NA -0.37 -5.77 -0.3 1.79e-8 Breast cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14797243 chr11:68671428 IGHMBP2;MRPL21 0.43 6.05 0.31 3.97e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg26354017 chr1:205819088 PM20D1 0.84 14.91 0.63 6.67e-39 Menarche (age at onset); LUSC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg12463550 chr7:65579703 CRCP -0.48 -7.11 -0.36 7.13e-12 Aortic root size; LUSC cis rs2273669 0.667 rs11754955 chr6:109287459 A/G cg05315195 chr6:109294784 ARMC2 -0.58 -6.41 -0.33 5.05e-10 Prostate cancer; LUSC cis rs11155671 0.530 rs9322228 chr6:150209309 C/G cg09699651 chr6:150184138 LRP11 0.45 7.17 0.37 4.98e-12 Testicular germ cell tumor; LUSC cis rs78761021 0.720 rs874307 chr17:9798074 C/G cg26853458 chr17:9805074 RCVRN 0.34 5.9 0.31 9.08e-9 Type 2 diabetes; LUSC cis rs11608355 0.846 rs35393419 chr12:109881809 C/T cg05360138 chr12:110035743 NA 0.59 7.6 0.38 3.02e-13 Neuroticism; LUSC cis rs7819412 0.595 rs10106914 chr8:10987651 T/G cg21775007 chr8:11205619 TDH -0.53 -7.54 -0.38 4.38e-13 Triglycerides; LUSC cis rs13385 0.815 rs34386219 chr5:139561906 G/A cg26211634 chr5:139558579 C5orf32 0.45 6.54 0.34 2.25e-10 Atrial fibrillation; LUSC cis rs921968 0.613 rs2710250 chr2:219543277 A/G cg02176678 chr2:219576539 TTLL4 -0.59 -10.45 -0.5 2.59e-22 Mean corpuscular hemoglobin concentration; LUSC trans rs7615952 0.546 rs2922171 chr3:125343193 C/T cg07211511 chr3:129823064 LOC729375 -0.53 -6.08 -0.32 3.25e-9 Blood pressure (smoking interaction); LUSC cis rs6060960 0.537 rs6089103 chr20:30464919 G/T cg13852791 chr20:30311386 BCL2L1 0.56 6.21 0.32 1.57e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7215564 0.908 rs4889879 chr17:78662573 A/T cg23238734 chr17:78661607 RPTOR -0.44 -5.82 -0.3 1.35e-8 Myopia (pathological); LUSC cis rs28830936 0.966 rs11635067 chr15:42124673 G/C cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.72 -0.3 2.37e-8 Diastolic blood pressure; LUSC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg14895029 chr7:2775587 GNA12 0.39 6.08 0.32 3.22e-9 Height; LUSC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg02275930 chr1:2372054 NA -0.54 -7.59 -0.38 3.1400000000000003e-13 Non-obstructive azoospermia; LUSC trans rs7937682 1.000 rs10789843 chr11:111576158 C/T cg18187862 chr3:45730750 SACM1L -0.53 -6.57 -0.34 1.99e-10 Primary sclerosing cholangitis; LUSC trans rs3806843 1.000 rs3733707 chr5:140181892 T/C cg25815440 chr2:42134162 NA -0.26 -6.02 -0.31 4.51e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg13607699 chr17:42295918 UBTF 0.55 8.34 0.42 1.93e-15 Total body bone mineral density; LUSC cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.5 0.56 1.14e-29 Motion sickness; LUSC cis rs6696846 0.765 rs61822567 chr1:205078725 T/C cg03948781 chr1:205179583 DSTYK 0.33 6.46 0.33 3.63e-10 Red blood cell count; LUSC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs734999 0.505 rs4445406 chr1:2539400 T/C cg18854424 chr1:2615690 NA 0.5 10.34 0.49 6.33e-22 Ulcerative colitis; LUSC cis rs9326248 0.581 rs7120706 chr11:116830087 C/T cg11861562 chr11:117069780 TAGLN -0.33 -6.42 -0.33 4.56e-10 Blood protein levels; LUSC cis rs7605827 0.897 rs7564514 chr2:15654808 G/A cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23702945 chr17:62131694 ERN1 0.42 6.08 0.32 3.27e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs791888 0.929 rs791887 chr10:89411554 A/G cg13926569 chr10:89418898 PAPSS2 -0.37 -7.31 -0.37 1.98e-12 Magnesium levels; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.16 0.77 1.43e-67 Prudent dietary pattern; LUSC cis rs55986470 0.817 rs72993054 chr2:239404244 C/T cg18131467 chr2:239335373 ASB1 -0.66 -6.49 -0.33 3.19e-10 Chronotype; LUSC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg17971929 chr21:40555470 PSMG1 -0.65 -10.61 -0.5 7.41e-23 Cognitive function; LUSC trans rs45509595 0.841 rs370155 chr6:27782031 T/G cg01620082 chr3:125678407 NA -0.64 -6.64 -0.34 1.24e-10 Breast cancer; LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs6430585 0.583 rs3769013 chr2:136556182 C/T cg07169764 chr2:136633963 MCM6 1.18 18.03 0.7 3.01e-51 Corneal structure; LUSC cis rs7523050 0.730 rs35100394 chr1:109433989 C/G cg08274380 chr1:109419600 GPSM2 1.13 11.51 0.53 4.76e-26 Fat distribution (HIV); LUSC cis rs314370 0.904 rs13244629 chr7:100509253 A/C cg18683606 chr7:100471612 SRRT 0.44 5.95 0.31 6.75e-9 Resting heart rate; LUSC cis rs67539049 1.000 rs68063127 chr8:11303726 G/C cg02771117 chr8:11279352 FAM167A;C8orf12 -0.41 -6.38 -0.33 5.98e-10 Itch intensity from mosquito bite; LUSC cis rs2439831 0.850 rs7169322 chr15:44131014 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.74 0.35 7.17e-11 Lung cancer in ever smokers; LUSC cis rs4820539 0.966 rs2267001 chr22:23456696 T/C cg21100191 chr22:23484243 RTDR1 0.86 14.34 0.62 1.11e-36 Bone mineral density; LUSC cis rs5770917 1.000 rs2073605 chr22:51008850 A/G cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.57 -5.67 -0.3 3.15e-8 Narcolepsy; LUSC cis rs925255 0.747 rs6547850 chr2:28629343 G/T cg01273330 chr2:28605224 NA 0.41 6.66 0.34 1.1e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -8.16 -0.41 6.74e-15 Type 2 diabetes; LUSC cis rs7712401 0.645 rs246316 chr5:122266197 T/C cg19077854 chr5:122220652 SNX24 0.42 9.36 0.46 1.18e-18 Mean platelet volume; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg10360139 chr7:1886902 MAD1L1 -0.38 -5.66 -0.3 3.31e-8 Bipolar disorder and schizophrenia; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg22907277 chr7:1156413 C7orf50 0.47 7.24 0.37 3.13e-12 Longevity;Endometriosis; LUSC cis rs2742234 0.955 rs2435384 chr10:43673731 G/T cg02780029 chr10:43622663 RET -0.33 -5.99 -0.31 5.43e-9 Hirschsprung disease; LUSC cis rs10779751 0.734 rs2261317 chr1:11124979 A/G cg04508216 chr1:11107452 MASP2 0.33 5.87 0.31 1.03e-8 Body mass index; LUSC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08109568 chr15:31115862 NA -0.61 -8.44 -0.42 9.67e-16 Huntington's disease progression; LUSC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg27572855 chr1:25598939 RHD -0.42 -7.45 -0.38 8.04e-13 Erythrocyte sedimentation rate; LUSC cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg00321850 chr1:175162397 KIAA0040 -0.44 -7.62 -0.38 2.63e-13 Alcohol dependence; LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg22907277 chr7:1156413 C7orf50 0.41 6.17 0.32 2.01e-9 Longevity;Endometriosis; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg04534504 chr10:62704143 RHOBTB1 0.38 6.31 0.33 8.84e-10 Educational attainment (years of education); LUSC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg16386425 chr10:429943 DIP2C -0.4 -6.34 -0.33 7.64e-10 Psychosis in Alzheimer's disease; LUSC cis rs17854409 0.881 rs12625401 chr20:61472939 A/T cg05147244 chr20:61493195 TCFL5 0.88 6.61 0.34 1.52e-10 Obesity-related traits; LUSC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg05738196 chr6:26577821 NA 0.79 15.16 0.64 7.07e-40 Intelligence (multi-trait analysis); LUSC cis rs6681460 0.649 rs7540195 chr1:67002406 C/T cg02459107 chr1:67143332 SGIP1 -0.37 -5.89 -0.31 9.44e-9 Presence of antiphospholipid antibodies; LUSC cis rs71403859 0.502 rs8051974 chr16:71488771 C/T cg08717414 chr16:71523259 ZNF19 -0.69 -8.51 -0.42 6.01e-16 Post bronchodilator FEV1; LUSC cis rs12760731 0.641 rs11588490 chr1:178328139 T/A cg00404053 chr1:178313656 RASAL2 0.57 6.07 0.32 3.44e-9 Obesity-related traits; LUSC trans rs3857536 0.776 rs4710583 chr6:66940101 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs611744 0.647 rs6981420 chr8:109266694 T/G cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.17e-10 Dupuytren's disease; LUSC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.63 -0.39 2.47e-13 Bipolar disorder; LUSC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg22903471 chr2:27725779 GCKR -0.4 -6.75 -0.35 6.7e-11 Menopause (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04522040 chr19:11039280 YIPF2;C19orf52 0.73 5.98 0.31 5.58e-9 Cognitive performance; LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg18099408 chr3:52552593 STAB1 -0.41 -7.1 -0.36 7.4e-12 Bipolar disorder; LUSC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg24399712 chr22:39784796 NA -0.62 -11.46 -0.53 7.19e-26 Intelligence (multi-trait analysis); LUSC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg18876405 chr7:65276391 NA -0.55 -8.66 -0.43 2.09e-16 Aortic root size; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg05896524 chr21:47604654 C21orf56 -0.53 -8.23 -0.41 4.26e-15 Testicular germ cell tumor; LUSC cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg16797656 chr11:68205561 LRP5 0.36 6.03 0.31 4.25e-9 Total body bone mineral density; LUSC cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.64 -9.39 -0.46 9.68e-19 Monocyte percentage of white cells; LUSC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg05368731 chr17:41323189 NBR1 0.83 14.2 0.61 4.02e-36 Menopause (age at onset); LUSC cis rs4363385 0.626 rs1108410 chr1:153005662 T/C cg25856811 chr1:152973957 SPRR3 -0.39 -6.44 -0.33 4.09e-10 Inflammatory skin disease; LUSC trans rs2797160 1.000 rs984040 chr6:126021277 A/G cg05039488 chr6:79577232 IRAK1BP1 0.45 6.88 0.35 3.03e-11 Endometrial cancer; LUSC cis rs9527 0.521 rs12259163 chr10:104961477 A/G cg23093090 chr10:104574429 C10orf26 -0.34 -6.28 -0.33 1.02e-9 Arsenic metabolism; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03591798 chr2:73404524 NA 0.44 6.3 0.33 9.14e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg01802117 chr1:53393560 SCP2 0.38 6.14 0.32 2.4e-9 Monocyte count; LUSC cis rs9473147 0.571 rs9369717 chr6:47554468 T/G cg20196966 chr6:47445060 CD2AP 0.43 6.04 0.31 4e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs1570884 0.516 rs7330830 chr13:50167929 T/A cg08779649 chr13:50194554 NA 0.39 6.59 0.34 1.72e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs11264799 0.765 rs6427389 chr1:157632011 C/A cg18268488 chr1:157545234 FCRL4 0.33 6.03 0.31 4.27e-9 IgA nephropathy; LUSC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.22 0.59 2.22e-32 Hip circumference adjusted for BMI; LUSC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.42 6.05 0.31 3.9e-9 Breast cancer; LUSC cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg21535247 chr6:8435926 SLC35B3 0.58 9.15 0.45 5.86e-18 Motion sickness; LUSC cis rs62400317 0.762 rs10484625 chr6:44823449 G/A cg20913747 chr6:44695427 NA -0.47 -7.44 -0.38 8.51e-13 Total body bone mineral density; LUSC cis rs2840044 0.534 rs321596 chr17:33885736 C/T cg05299278 chr17:33885742 SLFN14 -0.33 -7.44 -0.38 8.86e-13 Response to radiotherapy in cancer (late toxicity); LUSC cis rs7267979 1.000 rs4815417 chr20:25379526 C/T cg08601574 chr20:25228251 PYGB -0.41 -6.32 -0.33 8.57e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1059312 0.500 rs12303338 chr12:129276641 C/T cg09035930 chr12:129282057 SLC15A4 -0.57 -9.84 -0.47 3.03e-20 Systemic lupus erythematosus; LUSC cis rs7267979 1.000 rs7267979 chr20:25298087 C/T cg08601574 chr20:25228251 PYGB 0.46 6.98 0.36 1.62e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg17143192 chr8:8559678 CLDN23 0.56 7.83 0.39 6.51e-14 Obesity-related traits; LUSC cis rs870825 0.929 rs1405941 chr4:185591518 A/C cg04058563 chr4:185651563 MLF1IP -0.82 -10.98 -0.51 3.75e-24 Blood protein levels; LUSC cis rs4400599 0.618 rs10908751 chr1:154187305 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.92 -0.31 7.78e-9 Platelet distribution width; LUSC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg11752832 chr7:134001865 SLC35B4 0.59 9.09 0.45 8.87e-18 Mean platelet volume; LUSC cis rs7560272 0.538 rs6732812 chr2:73922475 T/C cg20560298 chr2:73613845 ALMS1 0.4 6.26 0.32 1.16e-9 Schizophrenia; LUSC cis rs8114671 0.562 rs6088635 chr20:33466501 A/G cg08999081 chr20:33150536 PIGU 0.32 5.68 0.3 2.91e-8 Height; LUSC cis rs1018836 0.923 rs9643308 chr8:91625399 A/C cg16814680 chr8:91681699 NA -0.77 -12.95 -0.58 2.23e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7180079 1.000 rs8034610 chr15:64628917 G/A cg02848875 chr15:64387786 SNX1 0.41 5.84 0.3 1.27e-8 Monocyte count; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg03354898 chr7:1950403 MAD1L1 -0.43 -8.61 -0.43 2.92e-16 Bipolar disorder and schizophrenia; LUSC cis rs2439831 0.867 rs12323999 chr15:43683115 T/A cg02155558 chr15:43621948 ADAL;LCMT2 1.04 12.58 0.57 5.75e-30 Lung cancer in ever smokers; LUSC cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg22875332 chr1:76189707 ACADM -0.39 -5.8 -0.3 1.51e-8 Daytime sleep phenotypes; LUSC cis rs864537 0.590 rs1214596 chr1:167427170 A/T cg22356347 chr1:167427500 CD247 0.35 8.17 0.41 6.39e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs4595586 0.545 rs1607041 chr12:39368206 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.15 0.32 2.16e-9 Morning vs. evening chronotype; LUSC trans rs11264799 0.716 rs1113662 chr1:157635825 T/C cg25498969 chr3:136062740 STAG1 -0.24 -5.98 -0.31 5.65e-9 IgA nephropathy; LUSC cis rs716595 1.000 rs12416343 chr10:111992624 G/C cg13996003 chr10:112034540 MXI1 -0.7 -5.81 -0.3 1.42e-8 Normalized brain volume; LUSC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2354432 0.505 rs7551766 chr1:146858964 A/G cg25205988 chr1:146714368 CHD1L -0.92 -7.63 -0.39 2.44e-13 Mitochondrial DNA levels; LUSC trans rs6502050 0.835 rs4789751 chr17:80092373 G/T cg07393940 chr7:158741817 NA 0.38 6.88 0.35 2.9100000000000002e-11 Life satisfaction; LUSC cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.46 6.29 0.33 1.02e-9 Multiple sclerosis; LUSC cis rs62458065 0.713 rs28421905 chr7:32489501 G/A cg20159608 chr7:32802032 NA -0.73 -9.21 -0.45 3.77e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg27535305 chr1:53392650 SCP2 -0.4 -7.36 -0.37 1.44e-12 Monocyte count; LUSC cis rs2070433 0.752 rs60290737 chr21:47837630 C/A cg12379764 chr21:47803548 PCNT 0.76 8.92 0.44 3.04e-17 Lymphocyte counts; LUSC cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg23788917 chr6:8435910 SLC35B3 0.5 7.31 0.37 2.03e-12 Motion sickness; LUSC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg22590775 chr19:49891494 CCDC155 0.57 7.48 0.38 6.73e-13 Multiple sclerosis; LUSC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25401140 chr17:37558857 FBXL20 -0.41 -6.16 -0.32 2.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6918586 0.615 rs198824 chr6:26122783 T/C cg17691542 chr6:26056736 HIST1H1C 0.39 5.88 0.31 9.87e-9 Schizophrenia; LUSC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg25319279 chr11:5960081 NA -0.37 -5.76 -0.3 1.88e-8 DNA methylation (variation); LUSC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.28 0.37 2.47e-12 Mean platelet volume; LUSC cis rs12908161 1.000 rs35808647 chr15:85377441 G/A cg17507749 chr15:85114479 UBE2QP1 0.52 6.3 0.33 9.57e-10 Schizophrenia; LUSC cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg12165864 chr7:66369176 NA -0.51 -6.75 -0.35 6.58e-11 Corneal structure; LUSC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg13206674 chr6:150067644 NUP43 0.57 8.99 0.44 1.91e-17 Lung cancer; LUSC cis rs9527 0.590 rs10786741 chr10:104939182 G/A cg05855489 chr10:104503620 C10orf26 0.52 7.91 0.4 3.9e-14 Arsenic metabolism; LUSC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg19592336 chr6:28129416 ZNF389 0.48 6.25 0.32 1.22e-9 Depression; LUSC cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg13535736 chr9:111863775 C9orf5 -0.38 -6.1 -0.32 2.99e-9 Menarche (age at onset); LUSC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg11645453 chr3:52864694 ITIH4 0.33 7.6 0.38 3.08e-13 Electroencephalogram traits; LUSC cis rs3008870 1.000 rs3008859 chr1:67390999 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.13 0.64 9.04e-40 Lymphocyte percentage of white cells; LUSC cis rs10193935 0.901 rs2088281 chr2:42672731 A/G cg27598129 chr2:42591480 NA 0.61 8.22 0.41 4.56e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs10170846 0.626 rs9288575 chr2:223495133 A/C cg25565276 chr2:223520875 FARSB 1.11 16.47 0.67 4.93e-45 Schizophrenia (inflammation and infection response interaction); LUSC cis rs11077998 0.967 rs4789796 chr17:80521135 T/C cg10255544 chr17:80519551 FOXK2 0.38 6.24 0.32 1.33e-9 Reticulocyte fraction of red cells; LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg22166914 chr1:53195759 ZYG11B 0.5 7.96 0.4 2.78e-14 Monocyte count; LUSC cis rs12421382 0.659 rs11213103 chr11:109385935 A/G cg27471124 chr11:109292789 C11orf87 0.43 7.67 0.39 1.86e-13 Schizophrenia; LUSC cis rs7759001 0.817 rs6920362 chr6:27351239 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 2.04e-8 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg11062466 chr8:58055876 NA 0.5 6.45 0.33 3.85e-10 Developmental language disorder (linguistic errors); LUSC trans rs3813948 0.543 rs2808468 chr1:207280703 A/G cg23343680 chr15:51397292 TNFAIP8L3 -0.53 -6.09 -0.32 3.17e-9 C4b binding protein levels; LUSC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg06238570 chr21:40685208 BRWD1 0.49 7.51 0.38 5.59e-13 Cognitive function; LUSC cis rs72781680 1.000 rs12616899 chr2:24165235 A/G cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.9 0.77 1.58e-66 Prudent dietary pattern; LUSC cis rs826838 0.616 rs10880738 chr12:38617762 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.75 -0.35 6.46e-11 Heart rate; LUSC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg23281280 chr6:28129359 ZNF389 -0.49 -6.35 -0.33 7.17e-10 Parkinson's disease; LUSC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg18681998 chr4:17616180 MED28 0.75 13.11 0.58 5.78e-32 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg22963979 chr7:1858916 MAD1L1 -0.6 -9.52 -0.46 3.54e-19 Bipolar disorder and schizophrenia; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg00149659 chr3:10157352 C3orf10 0.88 12.2 0.56 1.44e-28 Alzheimer's disease; LUSC cis rs1878931 0.535 rs7188903 chr16:3412861 A/G cg22508957 chr16:3507546 NAT15 -0.4 -5.74 -0.3 2.14e-8 Body mass index (adult); LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg17178900 chr1:205818956 PM20D1 0.52 8.2 0.41 5.18e-15 Menarche (age at onset); LUSC cis rs3820928 0.874 rs1917127 chr2:227895125 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.57 -0.38 3.59e-13 Pulmonary function; LUSC cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg14584255 chr6:163149320 PACRG;PARK2 -0.34 -6.6 -0.34 1.66e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs55883249 1.000 rs10495571 chr2:9736066 A/G cg23886495 chr2:9695866 ADAM17 0.48 5.68 0.3 3e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9467711 0.606 rs9358932 chr6:26362705 A/G cg09904177 chr6:26538194 HMGN4 0.69 6.68 0.34 1.02e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg11062466 chr8:58055876 NA 0.75 9.12 0.45 7.24e-18 Developmental language disorder (linguistic errors); LUSC cis rs9807841 0.555 rs6511708 chr19:10788813 A/G cg09936142 chr19:10668400 KRI1 -0.44 -6.93 -0.35 2.23e-11 Inflammatory skin disease; LUSC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg12963246 chr6:28129442 ZNF389 0.52 7.18 0.37 4.53e-12 Depression; LUSC cis rs7937682 0.575 rs34695265 chr11:111719128 T/C cg09085632 chr11:111637200 PPP2R1B 0.96 13.57 0.6 1.08e-33 Primary sclerosing cholangitis; LUSC cis rs11098499 0.754 rs34425882 chr4:120253177 G/A cg09307838 chr4:120376055 NA 0.7 10.67 0.5 4.72e-23 Corneal astigmatism; LUSC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11644478 chr21:40555479 PSMG1 0.64 10.63 0.5 6.41e-23 Cognitive function; LUSC cis rs7759001 0.857 rs9468116 chr6:27366812 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs11190604 1.000 rs2489035 chr10:102319395 C/T cg16342193 chr10:102329863 NA -0.36 -6.37 -0.33 6.22e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6977660 0.714 rs10249635 chr7:19787090 A/G cg07541023 chr7:19748670 TWISTNB 0.66 6.56 0.34 2.08e-10 Thyroid stimulating hormone; LUSC cis rs10979 1.000 rs9496671 chr6:143884742 G/A cg25407410 chr6:143891975 LOC285740 -0.73 -11.66 -0.54 1.35e-26 Hypospadias; LUSC cis rs6733011 0.578 rs10181972 chr2:99497284 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.38 -0.33 6.08e-10 Bipolar disorder; LUSC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg07701084 chr6:150067640 NUP43 0.48 6.98 0.36 1.63e-11 Lung cancer; LUSC cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 6.41 0.33 4.97e-10 Personality dimensions; LUSC cis rs9640161 0.789 rs34495356 chr7:150057791 A/G cg10018233 chr7:150070692 REPIN1 0.37 6.49 0.33 3.07e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs79349575 0.783 rs56046215 chr17:47008757 A/T cg22482690 chr17:47019901 SNF8 0.38 7.18 0.37 4.44e-12 Type 2 diabetes; LUSC cis rs10186029 0.548 rs4673728 chr2:214001997 C/G cg08319019 chr2:214017104 IKZF2 0.49 7.51 0.38 5.55e-13 Systemic sclerosis; LUSC cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg18932078 chr1:2524107 MMEL1 -0.3 -6.54 -0.34 2.37e-10 Ulcerative colitis; LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg16606324 chr3:10149918 C3orf24 0.68 9.78 0.47 4.89e-20 Alzheimer's disease; LUSC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg06634786 chr22:41940651 POLR3H 0.53 6.39 0.33 5.71e-10 Vitiligo; LUSC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg08645402 chr16:4508243 NA 0.49 7.76 0.39 1.02e-13 Schizophrenia; LUSC cis rs6733011 0.600 rs1568213 chr2:99432063 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.16 -0.32 2.07e-9 Bipolar disorder; LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg16132339 chr22:24313637 DDTL;DDT 0.38 5.79 0.3 1.62e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs546131 0.928 rs558967 chr11:34827168 T/A cg06937548 chr11:34938143 PDHX;APIP 0.46 6.49 0.33 3.08e-10 Lung disease severity in cystic fibrosis; LUSC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg24733560 chr20:60626293 TAF4 -0.43 -7.88 -0.4 4.78e-14 Body mass index; LUSC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg12463550 chr7:65579703 CRCP -0.48 -7.11 -0.36 7.13e-12 Aortic root size; LUSC cis rs12971120 0.891 rs3794953 chr18:72180519 C/T cg26446133 chr18:72167187 CNDP2 -0.76 -9.06 -0.44 1.11e-17 Refractive error; LUSC cis rs62400317 0.859 rs10456546 chr6:45217424 C/T cg20913747 chr6:44695427 NA -0.48 -7.72 -0.39 1.36e-13 Total body bone mineral density; LUSC cis rs9815354 0.812 rs60927633 chr3:41844010 C/T cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7508679 1.000 rs7248104 chr19:7224431 A/G cg00428638 chr19:7224713 INSR 0.39 8.11 0.41 9.46e-15 Hypothyroidism; LUSC cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg13736514 chr6:26305472 NA 0.47 9.49 0.46 4.53e-19 Educational attainment; LUSC trans rs6582630 0.502 rs11520279 chr12:38360871 A/G cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.28e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs3733585 0.699 rs13328050 chr4:9951120 G/T cg26043149 chr18:55253948 FECH -0.43 -6.51 -0.34 2.83e-10 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4594175 0.926 rs10149006 chr14:51615265 A/C cg23942311 chr14:51606299 NA 0.31 5.95 0.31 6.79e-9 Cancer; LUSC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg00129232 chr17:37814104 STARD3 -0.47 -7.0 -0.36 1.39e-11 Asthma; LUSC cis rs12618769 0.520 rs11892744 chr2:99237792 C/T cg10123293 chr2:99228465 UNC50 0.47 7.39 0.37 1.18e-12 Bipolar disorder; LUSC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.88 0.48 2.35e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg07959070 chr22:50026188 C22orf34 -0.37 -7.58 -0.38 3.43e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6424115 0.733 rs2502996 chr1:24199041 T/C cg10978503 chr1:24200527 CNR2 0.53 13.1 0.58 6.34e-32 Immature fraction of reticulocytes; LUSC cis rs12310956 0.532 rs6488187 chr12:33975029 C/T cg06521331 chr12:34319734 NA -0.45 -7.41 -0.38 1.02e-12 Morning vs. evening chronotype; LUSC cis rs748404 0.660 rs690012 chr15:43719755 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.74 0.3 2.08e-8 Lung cancer; LUSC cis rs765787 0.530 rs12903149 chr15:45539076 G/A cg24006582 chr15:45444508 DUOX1 0.66 9.32 0.45 1.65e-18 Uric acid levels; LUSC cis rs67311347 0.577 rs2371129 chr3:40248393 C/T cg09455208 chr3:40491958 NA -0.48 -8.8 -0.43 7.25e-17 Renal cell carcinoma; LUSC cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg16339924 chr4:17578868 LAP3 0.6 9.3 0.45 1.94e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9473147 0.516 rs9395286 chr6:47575332 T/C cg02130027 chr6:47444894 CD2AP 0.36 5.77 0.3 1.78e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs2710642 0.962 rs1828398 chr2:63034870 A/G cg17519650 chr2:63277830 OTX1 -0.47 -6.64 -0.34 1.29e-10 LDL cholesterol levels;LDL cholesterol; LUSC cis rs751728 0.664 rs12196293 chr6:33749151 A/G cg25922239 chr6:33757077 LEMD2 0.43 6.44 0.33 4.21e-10 Crohn's disease; LUSC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.82 0.51 1.4e-23 Menopause (age at onset); LUSC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg24399712 chr22:39784796 NA -0.63 -11.38 -0.53 1.36e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs765787 0.530 rs11070451 chr15:45533541 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.7 -0.43 1.5e-16 Uric acid levels; LUSC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg23158103 chr7:148848205 ZNF398 -0.43 -7.05 -0.36 1.01e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs3749237 0.964 rs34522271 chr3:49808517 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.99 0.36 1.49e-11 Resting heart rate; LUSC cis rs10089 1.000 rs4836363 chr5:127462737 G/C cg19767477 chr5:127420684 SLC12A2 -0.42 -5.65 -0.3 3.46e-8 Ileal carcinoids; LUSC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24591563 chr3:40498842 RPL14 0.37 6.18 0.32 1.89e-9 Triglycerides; LUSC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg09455208 chr3:40491958 NA 0.59 10.09 0.48 4.36e-21 Renal cell carcinoma; LUSC cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg14438399 chr17:27053147 TLCD1 0.52 5.75 0.3 2.05e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs2898290 0.622 rs1478890 chr8:11355602 C/G cg08975724 chr8:8085496 FLJ10661 -0.41 -6.06 -0.31 3.68e-9 Systolic blood pressure; LUSC cis rs2354432 1.000 rs2120003 chr1:146690635 A/G cg25205988 chr1:146714368 CHD1L 0.81 7.95 0.4 2.89e-14 Mitochondrial DNA levels; LUSC trans rs7647973 0.626 rs12715437 chr3:49751856 T/C cg21659725 chr3:3221576 CRBN -0.67 -7.97 -0.4 2.5e-14 Menarche (age at onset); LUSC cis rs3099143 1.000 rs3099138 chr15:77115524 G/A cg21673338 chr15:77095150 SCAPER -0.78 -7.25 -0.37 2.92e-12 Recalcitrant atopic dermatitis; LUSC cis rs765787 0.530 rs7167389 chr15:45535683 A/G cg24006582 chr15:45444508 DUOX1 -0.61 -8.87 -0.44 4.61e-17 Uric acid levels; LUSC trans rs2797160 0.935 rs12717178 chr6:126016499 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.85 0.35 3.56e-11 Endometrial cancer; LUSC cis rs17608059 0.518 rs4792436 chr17:13972307 T/A cg27005118 chr17:13972210 COX10 0.51 9.92 0.48 1.68e-20 Temperament; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 4.95e-14 Prudent dietary pattern; LUSC cis rs1775715 0.737 rs2808090 chr10:32143208 A/C cg04359828 chr10:32216031 ARHGAP12 0.39 6.73 0.35 7.23e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg00745463 chr17:30367425 LRRC37B -0.76 -8.64 -0.43 2.44e-16 Hip circumference adjusted for BMI; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg22143856 chr6:28129313 ZNF389 0.43 5.83 0.3 1.34e-8 Parkinson's disease; LUSC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg24250549 chr1:154909240 PMVK -0.65 -10.67 -0.5 4.63e-23 Prostate cancer; LUSC cis rs3960554 0.808 rs78811105 chr7:75702795 G/A cg17325771 chr7:75508891 RHBDD2 -0.4 -5.65 -0.3 3.52e-8 Eotaxin levels; LUSC cis rs208520 0.909 rs58958359 chr6:67021381 A/C cg07460842 chr6:66804631 NA 0.88 8.93 0.44 2.87e-17 Exhaled nitric oxide output; LUSC cis rs7937682 1.000 rs11608122 chr11:111535105 C/T cg19812747 chr11:111475976 SIK2 0.49 6.76 0.35 6.35e-11 Primary sclerosing cholangitis; LUSC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12667521 chr19:29218732 NA 0.61 8.81 0.43 7.07e-17 Methadone dose in opioid dependence; LUSC cis rs9393777 0.623 rs7773938 chr6:26474044 C/T cg05738196 chr6:26577821 NA -0.52 -5.76 -0.3 1.86e-8 Intelligence (multi-trait analysis); LUSC cis rs62103177 0.525 rs62101233 chr18:77724288 C/T cg20368463 chr18:77673604 PQLC1 0.74 7.82 0.39 6.93e-14 Opioid sensitivity; LUSC cis rs2190422 0.677 rs2190419 chr7:103073087 C/G cg04218035 chr7:103086829 SLC26A5 0.32 6.25 0.32 1.23e-9 Morning vs. evening chronotype; LUSC cis rs9581857 0.579 rs3759434 chr13:27997700 A/C cg22138327 chr13:27999177 GTF3A 0.8 10.51 0.5 1.6e-22 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.17 0.52 7.69e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1865760 0.865 rs1541987 chr6:25950397 A/G cg16482183 chr6:26056742 HIST1H1C -0.46 -6.81 -0.35 4.5e-11 Height; LUSC cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.9 -0.55 1.86e-27 Chronic sinus infection; LUSC cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg07148914 chr20:33460835 GGT7 0.46 6.73 0.35 7.48e-11 Height; LUSC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11644478 chr21:40555479 PSMG1 0.92 18.12 0.7 1.36e-51 Cognitive function; LUSC cis rs7937682 0.632 rs11214037 chr11:111773296 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.59 0.57 5.09e-30 Primary sclerosing cholangitis; LUSC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg21016266 chr12:122356598 WDR66 0.62 9.52 0.46 3.53e-19 Mean platelet volume; LUSC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg19468946 chr17:37922297 IKZF3 -0.39 -6.15 -0.32 2.19e-9 Self-reported allergy; LUSC cis rs2414856 0.510 rs72756984 chr15:64589419 T/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg05872129 chr22:39784769 NA -0.61 -11.56 -0.53 3.28e-26 Intelligence (multi-trait analysis); LUSC cis rs7927771 0.524 rs7122182 chr11:47843133 A/C cg20307385 chr11:47447363 PSMC3 -0.45 -6.69 -0.34 9.64e-11 Subjective well-being; LUSC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg20573242 chr4:122745356 CCNA2 0.43 6.65 0.34 1.19e-10 Type 2 diabetes; LUSC cis rs17270561 0.583 rs7749149 chr6:25781139 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 6.65 0.34 1.19e-10 Iron status biomarkers; LUSC cis rs13089785 1.000 rs2271969 chr3:123650432 A/G cg01860459 chr3:123419554 MYLK 0.35 5.9 0.31 9.15e-9 Intelligence (multi-trait analysis); LUSC cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg27432699 chr2:27873401 GPN1 -0.59 -9.0 -0.44 1.72e-17 Total body bone mineral density; LUSC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -12.06 -0.55 4.59e-28 Type 2 diabetes; LUSC cis rs1044826 0.956 rs7374385 chr3:139118544 A/C cg00490450 chr3:139108681 COPB2 0.56 7.41 0.38 1.05e-12 Obesity-related traits; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.0 0.44 1.77e-17 Prudent dietary pattern; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10545536 chr3:45635693 LIMD1 0.73 6.28 0.32 1.03e-9 Cognitive performance; LUSC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg25427524 chr10:38739819 LOC399744 0.68 12.34 0.56 4.54e-29 Extrinsic epigenetic age acceleration; LUSC cis rs921968 0.541 rs7583449 chr2:219403022 A/C cg02176678 chr2:219576539 TTLL4 -0.74 -14.17 -0.61 4.95e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs765787 0.530 rs28526629 chr15:45540462 C/T cg24006582 chr15:45444508 DUOX1 -0.61 -8.75 -0.43 1.07e-16 Uric acid levels; LUSC cis rs55728055 0.661 rs9619217 chr22:32043611 A/G cg01338084 chr22:32026380 PISD 0.83 6.34 0.33 7.32e-10 Age-related hearing impairment; LUSC cis rs2742234 0.541 rs7073849 chr10:43740474 G/C cg02780029 chr10:43622663 RET 0.34 5.73 0.3 2.24e-8 Hirschsprung disease; LUSC cis rs11711311 1.000 rs9288982 chr3:113470149 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 6.98 0.36 1.64e-11 IgG glycosylation; LUSC cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.49 -0.5 1.91e-22 Glomerular filtration rate (creatinine); LUSC cis rs11166629 0.883 rs11778878 chr8:135599220 C/T cg21672855 chr8:135614777 ZFAT -0.37 -5.94 -0.31 7.16e-9 Smoking quantity; LUSC cis rs2637266 1.000 rs12252604 chr10:78352591 T/C cg18941641 chr10:78392320 NA 0.37 6.82 0.35 4.18e-11 Pulmonary function; LUSC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg04369109 chr6:150039330 LATS1 -0.55 -8.13 -0.41 8.39e-15 Lung cancer; LUSC cis rs6939532 0.522 rs9358933 chr6:26363688 C/T cg05738196 chr6:26577821 NA -0.41 -5.66 -0.3 3.19e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs17095355 0.818 rs57239324 chr10:111770871 T/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -6.82 -0.35 4.38e-11 Biliary atresia; LUSC cis rs7202877 0.610 rs4536500 chr16:75343197 C/G cg04384234 chr16:75411784 CFDP1 0.64 8.84 0.44 5.71e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs11971779 0.715 rs7779390 chr7:139112953 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg07507251 chr3:52567010 NT5DC2 0.32 6.3 0.33 9.33e-10 Bipolar disorder; LUSC cis rs950776 1.000 rs950776 chr15:78926018 A/G cg06917634 chr15:78832804 PSMA4 0.65 10.03 0.48 7.21e-21 Sudden cardiac arrest; LUSC cis rs1372520 0.766 rs2583961 chr4:90779758 A/G cg01966878 chr4:90757139 SNCA -0.42 -5.92 -0.31 7.9e-9 Neuroticism; LUSC trans rs9291683 0.566 rs13115776 chr4:10040189 C/G cg26043149 chr18:55253948 FECH 0.48 7.07 0.36 9.06e-12 Bone mineral density; LUSC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg02951883 chr7:2050386 MAD1L1 -0.5 -8.72 -0.43 1.34e-16 Schizophrenia; LUSC cis rs2806561 0.929 rs641452 chr1:23538386 A/G cg19743168 chr1:23544995 NA 0.47 10.3 0.49 8.8e-22 Height; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg22331106 chr13:45563688 KIAA1704;NUFIP1 0.53 6.11 0.32 2.81e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg14789911 chr21:47582049 C21orf56 -0.37 -5.82 -0.3 1.42e-8 Testicular germ cell tumor; LUSC cis rs7267979 0.966 rs6083855 chr20:25405118 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6546550 0.743 rs6546548 chr2:70017022 A/G cg02498382 chr2:70120550 SNRNP27 -0.25 -6.21 -0.32 1.57e-9 Prevalent atrial fibrillation; LUSC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg00933542 chr6:150070202 PCMT1 0.31 6.53 0.34 2.48e-10 Lung cancer; LUSC trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9646954 0.542 rs3828193 chr2:101031561 A/C cg08017756 chr2:100939284 LONRF2 0.47 8.68 0.43 1.71e-16 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.659 rs12602808 chr17:56698420 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.61 0.6 7.09e-34 Cognitive test performance; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.61e-17 Prudent dietary pattern; LUSC cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs12594515 0.967 rs12595138 chr15:45986108 G/C cg06207120 chr15:45996521 NA 0.39 5.9 0.31 8.8e-9 Waist circumference;Weight; LUSC cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg23711669 chr6:146136114 FBXO30 -0.74 -13.05 -0.58 1.02e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.818 rs426360 chr1:153014710 C/T cg00922841 chr1:152955080 SPRR1A -0.43 -7.55 -0.38 4.26e-13 Inflammatory skin disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20404643 chr11:1492543 HCCA2 0.44 6.39 0.33 5.61e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11098499 0.820 rs28578366 chr4:120536905 A/G cg09307838 chr4:120376055 NA -0.67 -10.1 -0.48 4.29e-21 Corneal astigmatism; LUSC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg14552801 chr7:65878734 NA 0.38 5.91 0.31 8.41e-9 Aortic root size; LUSC cis rs2078087 0.568 rs656664 chr1:183237940 G/A cg13843938 chr1:183241246 NMNAT2 -0.42 -6.82 -0.35 4.2e-11 Obesity-related traits; LUSC cis rs9325144 0.647 rs4616077 chr12:39092364 T/C cg26384229 chr12:38710491 ALG10B -0.63 -9.73 -0.47 7.46e-20 Morning vs. evening chronotype; LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg00814883 chr7:100076585 TSC22D4 -0.72 -9.54 -0.46 3.08e-19 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03142856 chr1:45271752 TCTEX1D4 0.41 6.08 0.32 3.23e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg11843238 chr5:131593191 PDLIM4 0.37 6.33 0.33 7.7e-10 Breast cancer; LUSC cis rs6500395 0.926 rs7192297 chr16:48670421 G/A cg04672837 chr16:48644449 N4BP1 0.46 6.91 0.35 2.41e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.03e-18 Menopause (age at onset); LUSC cis rs6688613 0.759 rs61815132 chr1:166920911 A/G cg07049167 chr1:166818506 POGK 0.41 6.02 0.31 4.56e-9 Refractive astigmatism; LUSC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg23711669 chr6:146136114 FBXO30 0.73 11.3 0.53 2.69e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs7572644 0.766 rs6745379 chr2:28147541 T/C cg27432699 chr2:27873401 GPN1 -0.52 -6.49 -0.33 3.05e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.24 -0.37 3.09e-12 Alzheimer's disease (late onset); LUSC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg27141850 chr2:20869434 GDF7 -0.34 -7.95 -0.4 2.85e-14 Abdominal aortic aneurysm; LUSC cis rs6736093 0.933 rs4848229 chr2:112692650 C/A cg12686935 chr2:112915763 FBLN7 -0.36 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs7584330 0.518 rs7561919 chr2:238435241 A/G cg16989719 chr2:238392110 NA -0.45 -6.03 -0.31 4.24e-9 Prostate cancer; LUSC cis rs17253792 0.822 rs17832365 chr14:56153531 C/G cg01858014 chr14:56050164 KTN1 -0.78 -6.43 -0.33 4.52e-10 Putamen volume; LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg11645453 chr3:52864694 ITIH4 0.32 7.48 0.38 6.77e-13 Bipolar disorder; LUSC cis rs6503525 0.701 rs28618095 chr17:38109075 T/C cg26162295 chr17:38119207 GSDMA -0.29 -6.52 -0.34 2.64e-10 Asthma; LUSC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg11632617 chr15:75315747 PPCDC -0.54 -6.97 -0.36 1.67e-11 Blood trace element (Zn levels); LUSC cis rs10791323 0.569 rs329664 chr11:133754975 G/T cg15485101 chr11:133734466 NA 0.38 7.03 0.36 1.19e-11 Childhood ear infection; LUSC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg07701084 chr6:150067640 NUP43 0.57 8.71 0.43 1.47e-16 Lung cancer; LUSC trans rs208520 0.690 rs12202805 chr6:66703903 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.06 -16.82 -0.68 2.02e-46 Exhaled nitric oxide output; LUSC cis rs12760731 0.623 rs10913550 chr1:178408795 A/G cg00404053 chr1:178313656 RASAL2 0.48 5.76 0.3 1.91e-8 Obesity-related traits; LUSC cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg22709100 chr7:91322751 NA -0.39 -5.66 -0.3 3.24e-8 Breast cancer; LUSC trans rs11039798 0.764 rs76882342 chr11:48939091 A/T cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.1 0.32 2.93e-9 Menopause (age at onset); LUSC cis rs9815354 0.767 rs60943892 chr3:41852307 T/C cg03022575 chr3:42003672 ULK4 0.85 8.74 0.43 1.16e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg13114125 chr14:105738426 BRF1 -0.92 -15.89 -0.66 9.54e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg22834771 chr12:69754056 YEATS4 -0.44 -6.63 -0.34 1.39e-10 Blood protein levels; LUSC cis rs6484504 0.652 rs674035 chr11:31399014 G/A cg06552810 chr11:31128660 NA 0.36 6.21 0.32 1.59e-9 Red blood cell count; LUSC cis rs9314323 0.798 rs12682345 chr8:26218332 A/G cg11498726 chr8:26250323 BNIP3L 0.43 6.26 0.32 1.21e-9 Red cell distribution width; LUSC cis rs9359856 0.564 rs72913921 chr6:90328692 A/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.16 -0.41 6.87e-15 Bipolar disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26784348 chr1:67520192 SLC35D1 -0.46 -6.31 -0.33 8.83e-10 Hepatitis; LUSC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -7.63 -0.39 2.48e-13 Hemoglobin concentration; LUSC cis rs701145 0.617 rs7426835 chr3:154049539 C/T cg10247383 chr3:153839028 SGEF -0.44 -5.75 -0.3 2.04e-8 Coronary artery disease; LUSC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.1 0.48 4.13e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg06808227 chr14:105710500 BRF1 -0.66 -10.29 -0.49 9.37e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs36093844 0.752 rs57534090 chr11:85573020 C/T cg25872744 chr11:85566296 CCDC83 -0.45 -5.78 -0.3 1.69e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs929596 0.556 rs35984508 chr2:234587852 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.19 -0.37 4.18e-12 Total bilirubin levels in HIV-1 infection; LUSC cis rs12540874 0.759 rs12718572 chr7:50573325 C/T cg18232548 chr7:50535776 DDC -0.56 -7.76 -0.39 1.05e-13 Systemic sclerosis; LUSC cis rs7582720 1.000 rs72932776 chr2:203688300 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 7.98 0.4 2.35e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg03188948 chr7:1209495 NA 0.47 6.27 0.32 1.13e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg03351412 chr1:154909251 PMVK 0.56 8.87 0.44 4.52e-17 Prostate cancer; LUSC cis rs6012953 1.000 rs6020560 chr20:49119419 T/C cg13958625 chr20:49123093 NA 0.31 6.57 0.34 1.88e-10 Vitiligo; LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18099408 chr3:52552593 STAB1 -0.38 -6.5 -0.34 2.84e-10 Electroencephalogram traits; LUSC cis rs1045714 0.895 rs2293405 chr7:2644607 G/T cg24848437 chr7:2645542 IQCE 0.61 6.81 0.35 4.56e-11 Urate levels in lean individuals; LUSC cis rs7712401 0.715 rs6859163 chr5:122354920 A/G cg19077854 chr5:122220652 SNX24 -0.41 -8.71 -0.43 1.45e-16 Mean platelet volume; LUSC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg09267113 chr7:98030324 BAIAP2L1 0.39 6.0 0.31 5.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg02487422 chr3:49467188 NICN1 0.44 7.13 0.36 6.21e-12 Intelligence (multi-trait analysis); LUSC cis rs73001065 0.818 rs58847337 chr19:19726022 G/A cg03709012 chr19:19516395 GATAD2A 0.89 7.12 0.36 6.51e-12 LDL cholesterol; LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg00431813 chr7:1051703 C7orf50 -0.41 -6.52 -0.34 2.64e-10 Longevity;Endometriosis; LUSC cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg00071950 chr4:10020882 SLC2A9 -0.52 -8.72 -0.43 1.34e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg04576048 chr1:205797593 PM20D1 0.33 5.91 0.31 8.26e-9 Menarche (age at onset); LUSC cis rs4290604 0.748 rs4549025 chr2:238052911 C/T cg23555395 chr2:238036564 NA 0.56 7.39 0.37 1.19e-12 Asthma; LUSC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg27170947 chr2:26402098 FAM59B 0.66 9.0 0.44 1.74e-17 Gut microbiome composition (summer); LUSC cis rs1215050 0.765 rs687795 chr4:98754912 C/G cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.25e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg13902645 chr11:5959945 NA 0.4 5.87 0.31 1.06e-8 DNA methylation (variation); LUSC cis rs9503598 0.662 rs2326232 chr6:3451953 A/G cg00476032 chr6:3446245 SLC22A23 0.31 6.1 0.32 2.94e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs6964587 0.869 rs2013334 chr7:91549657 G/A cg17063962 chr7:91808500 NA -0.53 -8.24 -0.41 3.87e-15 Breast cancer; LUSC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 13.69 0.6 3.54e-34 Gut microbiome composition (summer); LUSC cis rs2762353 0.935 rs1165209 chr6:25801319 G/A cg03264133 chr6:25882463 NA -0.42 -7.25 -0.37 2.97e-12 Blood metabolite levels; LUSC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg22535103 chr8:58192502 C8orf71 -0.76 -7.82 -0.39 7.04e-14 Developmental language disorder (linguistic errors); LUSC cis rs2667011 0.570 rs1397710 chr2:160860491 C/A cg06573604 chr2:160760825 LY75 -0.45 -6.7 -0.34 8.99e-11 Bilirubin levels; LUSC cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg26384229 chr12:38710491 ALG10B 0.89 15.27 0.64 2.63e-40 Bladder cancer; LUSC trans rs12579753 0.871 rs4255611 chr12:82215969 C/A cg07923666 chr12:49932857 KCNH3 -0.49 -6.12 -0.32 2.55e-9 Resting heart rate; LUSC cis rs193541 0.632 rs30063 chr5:122295693 G/A cg19077854 chr5:122220652 SNX24 0.4 8.56 0.42 4.32e-16 Glucose homeostasis traits; LUSC cis rs7914558 1.000 rs7899084 chr10:104872547 A/T cg05855489 chr10:104503620 C10orf26 0.6 9.68 0.47 1.1e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs7829975 0.688 rs7827182 chr8:8380471 C/G cg27411982 chr8:10470053 RP1L1 0.44 7.3 0.37 2.09e-12 Mood instability; LUSC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg17971929 chr21:40555470 PSMG1 -0.64 -10.46 -0.5 2.44e-22 Cognitive function; LUSC cis rs9318086 0.648 rs35449605 chr13:24472582 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.45 6.62 0.34 1.47e-10 Myopia (pathological); LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg16145915 chr7:1198662 ZFAND2A -0.74 -15.77 -0.65 3.01e-42 Longevity;Endometriosis; LUSC cis rs9814567 0.727 rs4245908 chr3:134349205 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.79 -12.92 -0.58 3e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11190604 0.767 rs10883490 chr10:102194775 C/T cg07080220 chr10:102295463 HIF1AN 0.61 7.91 0.4 3.71e-14 Palmitoleic acid (16:1n-7) levels; LUSC cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg08085267 chr17:45401833 C17orf57 -0.52 -8.2 -0.41 5.32e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.94 18.58 0.71 1.99e-53 Prudent dietary pattern; LUSC cis rs911119 0.913 rs6048924 chr20:23578996 G/A cg16589663 chr20:23618590 CST3 0.6 7.15 0.36 5.56e-12 Chronic kidney disease; LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg24813613 chr7:1882135 MAD1L1 -0.45 -7.33 -0.37 1.72e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs12760731 0.623 rs1342849 chr1:178296692 A/G cg00404053 chr1:178313656 RASAL2 0.47 5.81 0.3 1.48e-8 Obesity-related traits; LUSC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11644478 chr21:40555479 PSMG1 -0.82 -14.39 -0.62 7.1e-37 Cognitive function; LUSC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.77 -8.15 -0.41 7.49e-15 Initial pursuit acceleration; LUSC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg23985595 chr17:80112537 CCDC57 -0.3 -5.75 -0.3 2.05e-8 Life satisfaction; LUSC cis rs1801251 0.778 rs2592116 chr2:233735709 G/A cg08000102 chr2:233561755 GIGYF2 -0.51 -8.09 -0.4 1.13e-14 Coronary artery disease; LUSC trans rs9747201 0.963 rs11077982 chr17:80147377 G/C cg07393940 chr7:158741817 NA 0.54 8.75 0.43 1.06e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg00074818 chr8:8560427 CLDN23 0.58 9.88 0.48 2.23e-20 Obesity-related traits; LUSC cis rs250677 0.958 rs36070 chr5:148417240 T/C cg12140854 chr5:148520817 ABLIM3 -0.36 -5.88 -0.31 9.93e-9 Breast cancer; LUSC cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg18681998 chr4:17616180 MED28 -0.84 -14.22 -0.61 3.19e-36 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg11812906 chr14:75593930 NEK9 0.65 11.2 0.52 6.41e-25 Height; LUSC cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg14019146 chr3:50243930 SLC38A3 0.37 8.29 0.41 2.9e-15 Menarche (age at onset); LUSC cis rs11030122 0.702 rs4910866 chr11:3950554 A/T cg18678763 chr11:4115507 RRM1 -0.45 -5.76 -0.3 1.86e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg08847533 chr14:75593920 NEK9 0.49 7.1 0.36 7.68e-12 Caffeine consumption; LUSC cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg23711669 chr6:146136114 FBXO30 0.9 17.15 0.68 1.03e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg06784218 chr1:46089804 CCDC17 0.53 10.97 0.51 3.94e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.6 8.45 0.42 9.09e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs67981189 0.634 rs221891 chr14:71611627 C/T cg15816911 chr14:71606274 NA -0.35 -6.19 -0.32 1.72e-9 Schizophrenia; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg03461704 chr1:205818484 PM20D1 -0.35 -5.67 -0.3 3.11e-8 Menarche (age at onset); LUSC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg20503657 chr10:835505 NA 0.98 13.91 0.61 5.29e-35 Eosinophil percentage of granulocytes; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03646922 chr17:4167316 ANKFY1 -0.4 -6.83 -0.35 4.11e-11 Electrocardiographic conduction measures; LUSC cis rs7903847 0.642 rs11189177 chr10:99141663 C/T cg08345082 chr10:99160200 RRP12 -0.36 -7.28 -0.37 2.45e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg22823121 chr1:150693482 HORMAD1 0.49 6.98 0.36 1.63e-11 Melanoma; LUSC cis rs12931792 0.748 rs11150585 chr16:30184286 A/G cg17640201 chr16:30407289 ZNF48 0.63 10.3 0.49 8.45e-22 Tonsillectomy; LUSC cis rs9902453 0.967 rs1906450 chr17:28515744 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.46 0.42 8.27e-16 Coffee consumption (cups per day); LUSC cis rs79839061 0.666 rs62297063 chr4:869708 G/A cg07828340 chr4:882639 GAK 1.07 11.34 0.53 1.99e-25 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg22437258 chr11:111473054 SIK2 0.54 7.65 0.39 2.16e-13 Primary sclerosing cholangitis; LUSC cis rs1385374 0.858 rs11059930 chr12:129297860 T/C cg09035930 chr12:129282057 SLC15A4 -0.62 -6.66 -0.34 1.14e-10 Systemic lupus erythematosus; LUSC trans rs12579753 1.000 rs12811607 chr12:82233619 T/G cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC trans rs57221529 0.766 rs12522140 chr5:587261 C/A cg11887960 chr12:57824829 NA 0.56 6.84 0.35 3.75e-11 Lung disease severity in cystic fibrosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26541027 chr1:110163313 AMPD2 0.42 6.36 0.33 6.72e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.5 -0.34 2.94e-10 Alzheimer's disease (late onset); LUSC cis rs62400317 0.859 rs12205379 chr6:45215074 G/A cg20913747 chr6:44695427 NA -0.47 -7.7 -0.39 1.58e-13 Total body bone mineral density; LUSC cis rs317689 0.690 rs317656 chr12:69681101 T/A cg11871910 chr12:69753446 YEATS4 0.44 5.74 0.3 2.18e-8 Response to diuretic therapy; LUSC cis rs3859192 0.561 rs9916158 chr17:38182229 G/T cg17467752 chr17:38218738 THRA -0.54 -7.79 -0.39 8.48e-14 White blood cell count; LUSC cis rs6142102 0.961 rs2284389 chr20:32656841 C/G cg08999081 chr20:33150536 PIGU 0.34 5.87 0.31 1.07e-8 Skin pigmentation; LUSC cis rs7173743 0.756 rs8030937 chr15:79129587 G/T cg00540400 chr15:79124168 NA 0.35 5.94 0.31 7.12e-9 Coronary artery disease; LUSC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 10.67 0.5 4.62e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs2567519 0.710 rs2714012 chr17:70783757 C/T cg25142702 chr5:6378806 MED10 -0.38 -6.17 -0.32 2.01e-9 Smoking initiation; LUSC cis rs9640161 0.658 rs60467296 chr7:150015471 G/A cg17279839 chr7:150038598 RARRES2 0.43 6.78 0.35 5.58e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs61931739 0.500 rs7309421 chr12:34553795 C/T cg06521331 chr12:34319734 NA -0.4 -6.26 -0.32 1.2e-9 Morning vs. evening chronotype; LUSC cis rs4363385 0.530 rs11205181 chr1:153045728 C/T cg00922841 chr1:152955080 SPRR1A -0.38 -6.32 -0.33 8.25e-10 Inflammatory skin disease; LUSC cis rs17155006 0.718 rs370533 chr7:107746215 G/C cg05962710 chr7:107745446 LAMB4 -0.35 -6.23 -0.32 1.43e-9 Pneumococcal bacteremia; LUSC cis rs6977940 0.818 rs11770710 chr7:2896123 A/G cg19731401 chr7:2775893 GNA12 0.59 6.81 0.35 4.69e-11 White matter integrity; LUSC cis rs1949733 0.523 rs56053534 chr4:8542876 G/A cg13073564 chr4:8508604 NA 0.35 6.42 0.33 4.74e-10 Response to antineoplastic agents; LUSC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg03060546 chr3:49711283 APEH 0.7 11.67 0.54 1.28e-26 Resting heart rate; LUSC cis rs2249625 0.545 rs2496487 chr6:72875226 G/C cg18830697 chr6:72922368 RIMS1 -0.36 -7.17 -0.37 4.81e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC trans rs6601450 0.547 rs10105843 chr8:10197863 A/G cg15556689 chr8:8085844 FLJ10661 0.45 6.69 0.34 9.53e-11 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10752881 1.000 rs10752881 chr1:182973491 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.73 0.51 2.88e-23 Colorectal cancer; LUSC cis rs7903847 0.667 rs7096801 chr10:99140969 T/C cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.57e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs7759001 0.857 rs6934933 chr6:27354862 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.78 0.3 1.73e-8 Glomerular filtration rate (creatinine); LUSC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg04017836 chr7:65315216 NA -0.38 -6.0 -0.31 5.28e-9 Height; LUSC trans rs61931739 0.635 rs1825746 chr12:33939984 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.64 0.39 2.36e-13 Morning vs. evening chronotype; LUSC cis rs807669 0.742 rs1206544 chr22:19215039 C/T cg02655711 chr22:19163373 SLC25A1 0.76 14.74 0.63 3.11e-38 Metabolite levels; LUSC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg06740227 chr12:86229804 RASSF9 0.43 6.73 0.35 7.41e-11 Major depressive disorder; LUSC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg04450456 chr4:17643702 FAM184B -0.41 -6.64 -0.34 1.24e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9660992 0.710 rs1668864 chr1:205248799 T/C cg21643547 chr1:205240462 TMCC2 -0.51 -9.46 -0.46 5.85e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1113500 0.548 rs11185271 chr1:108659933 A/G cg11967332 chr1:108735228 SLC25A24 0.45 6.11 0.32 2.77e-9 Growth-regulated protein alpha levels; LUSC cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg24450063 chr1:156163899 SLC25A44 1.04 16.42 0.67 7.66e-45 Testicular germ cell tumor; LUSC cis rs2835872 0.965 rs857973 chr21:39007498 A/G cg20424643 chr21:39039972 KCNJ6 -0.39 -6.04 -0.31 4.1e-9 Electroencephalographic traits in alcoholism; LUSC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg22800045 chr5:56110881 MAP3K1 0.79 10.23 0.49 1.56e-21 Initial pursuit acceleration; LUSC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg08048268 chr3:133502702 NA -0.48 -9.32 -0.45 1.66e-18 Iron status biomarkers; LUSC cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg13531842 chr10:38383804 ZNF37A -0.44 -6.76 -0.35 6.1e-11 Extrinsic epigenetic age acceleration; LUSC trans rs75804782 0.641 rs2340870 chr2:239356026 C/T cg01134436 chr17:81009848 B3GNTL1 0.63 6.16 0.32 2.08e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg26314531 chr2:26401878 FAM59B 0.7 9.35 0.46 1.34e-18 Gut microbiome composition (summer); LUSC cis rs7100689 0.599 rs7077847 chr10:82134952 A/G cg01528321 chr10:82214614 TSPAN14 0.87 13.03 0.58 1.14e-31 Post bronchodilator FEV1; LUSC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.67 -10.47 -0.5 2.19e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs694739 0.628 rs538147 chr11:64129722 G/A cg02228329 chr11:64053129 BAD;GPR137 0.44 6.35 0.33 7.18e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg27311710 chr6:107349326 C6orf203 0.65 6.09 0.32 3.08e-9 Body mass index; LUSC trans rs4927850 0.958 rs1975582 chr3:195751439 G/T cg21051086 chr3:73046214 PPP4R2 -0.52 -7.92 -0.4 3.52e-14 Pancreatic cancer; LUSC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.53 8.41 0.42 1.22e-15 Depressive symptoms; LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg14004847 chr7:1930337 MAD1L1 -0.52 -7.83 -0.39 6.49e-14 Bipolar disorder and schizophrenia; LUSC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.4 -0.42 1.28e-15 Total body bone mineral density; LUSC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg06618935 chr21:46677482 NA -0.41 -7.85 -0.39 5.79e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3782089 1.000 rs3782089 chr11:65336819 C/T cg21890820 chr11:65308645 LTBP3 1.28 9.7 0.47 9.09e-20 Height; LUSC cis rs354225 0.544 rs12713267 chr2:54805607 T/C cg01766943 chr2:54829624 SPTBN1 0.48 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs714027 0.605 rs5753037 chr22:30581722 C/T cg11564601 chr22:30592435 NA 0.33 5.72 0.3 2.33e-8 Lymphocyte counts; LUSC cis rs7000551 0.715 rs1879792 chr8:22314029 C/A cg12081754 chr8:22256438 SLC39A14 0.48 7.21 0.37 3.65e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7312933 0.584 rs7974654 chr12:42630466 C/A cg01256987 chr12:42539512 GXYLT1 -0.42 -7.85 -0.39 5.68e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6967385 0.934 rs17149915 chr7:12384899 G/A cg06484146 chr7:12443880 VWDE 0.38 5.69 0.3 2.73e-8 Response to taxane treatment (placlitaxel); LUSC cis rs7659604 0.521 rs4240263 chr4:122683623 C/T cg19748678 chr4:122722346 EXOSC9 -0.4 -5.88 -0.31 9.96e-9 Type 2 diabetes; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg04267008 chr7:1944627 MAD1L1 -0.62 -9.65 -0.47 1.32e-19 Bipolar disorder and schizophrenia; LUSC cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg23260525 chr10:116636907 FAM160B1 0.47 10.19 0.49 2.13e-21 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs735860 0.718 rs209488 chr6:53177540 A/T cg10236188 chr6:53219634 NA 0.37 5.67 0.3 3.15e-8 Glaucoma; LUSC cis rs12594515 1.000 rs11070464 chr15:45984776 C/A cg19682013 chr15:45996608 NA 0.38 5.8 0.3 1.5e-8 Waist circumference;Weight; LUSC cis rs2637266 1.000 rs2395384 chr10:78335329 G/A cg18941641 chr10:78392320 NA 0.38 6.9 0.35 2.66e-11 Pulmonary function; LUSC cis rs7772486 0.875 rs6909827 chr6:146365738 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.58 0.43 3.51e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg17892150 chr10:133769511 PPP2R2D -0.68 -9.51 -0.46 4.05e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg18306943 chr3:40428807 ENTPD3 0.38 5.82 0.3 1.41e-8 Renal cell carcinoma; LUSC cis rs3007168 1.000 rs3007167 chr14:51613041 C/T cg23942311 chr14:51606299 NA 0.36 5.79 0.3 1.61e-8 Cancer; LUSC cis rs1941023 0.606 rs7946122 chr11:60172770 G/A cg08716584 chr11:60157161 MS4A7 -0.62 -11.34 -0.53 2.02e-25 Congenital heart disease (maternal effect); LUSC trans rs8002861 0.869 rs7989857 chr13:44464090 C/T cg12856521 chr11:46389249 DGKZ 0.4 6.28 0.32 1.06e-9 Leprosy; LUSC cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs7106204 0.609 rs11828535 chr11:24295565 G/C ch.11.24196551F chr11:24239977 NA 0.69 5.74 0.3 2.14e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4776059 0.916 rs2414161 chr15:52883285 T/C cg22715398 chr15:52968154 KIAA1370 -0.73 -10.44 -0.5 2.78e-22 Schizophrenia; LUSC cis rs7107174 1.000 rs9651769 chr11:77996166 T/C cg02023728 chr11:77925099 USP35 0.47 6.74 0.35 7.05e-11 Testicular germ cell tumor; LUSC cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg00268967 chr12:58002603 GEFT;DTX3 -0.36 -5.74 -0.3 2.18e-8 Celiac disease or Rheumatoid arthritis; LUSC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg03433033 chr1:76189801 ACADM 0.72 9.44 0.46 6.81e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7180079 1.000 rs11633312 chr15:64594611 T/C cg08069370 chr15:64387884 SNX1 0.55 6.02 0.31 4.63e-9 Monocyte count; LUSC cis rs7824557 0.564 rs2736302 chr8:11236419 T/C cg21775007 chr8:11205619 TDH -0.65 -10.36 -0.49 5.25e-22 Retinal vascular caliber; LUSC cis rs7824557 0.527 rs57629785 chr8:11235150 C/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.93 -0.31 7.5e-9 Retinal vascular caliber; LUSC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.7 -0.39 1.59e-13 Height; LUSC cis rs500891 0.525 rs1144177 chr6:84029793 A/G cg08257003 chr6:84140564 ME1 0.34 8.05 0.4 1.43e-14 Platelet-derived growth factor BB levels; LUSC cis rs939574 0.799 rs1109867 chr2:220083453 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.94 -8.06 -0.4 1.42e-14 Platelet distribution width; LUSC trans rs7726839 0.540 rs7558 chr5:660491 C/T cg25482853 chr8:67687455 SGK3 1.09 15.46 0.65 4.65e-41 Obesity-related traits; LUSC cis rs394563 0.602 rs409111 chr6:149766860 A/G cg16235748 chr6:149772707 ZC3H12D -0.29 -5.95 -0.31 6.72e-9 Dupuytren's disease; LUSC cis rs1448094 0.935 rs11117108 chr12:86322310 T/A cg02569458 chr12:86230093 RASSF9 0.42 6.86 0.35 3.31e-11 Major depressive disorder; LUSC cis rs3007168 0.951 rs3007078 chr14:51612550 T/A cg23942311 chr14:51606299 NA 0.35 5.74 0.3 2.09e-8 Cancer; LUSC cis rs9309473 1.000 rs11893881 chr2:73824373 T/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.9 -0.35 2.65e-11 Metabolite levels; LUSC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg25072359 chr17:41440525 NA 0.65 9.26 0.45 2.46e-18 Menopause (age at onset); LUSC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg09021430 chr5:549028 NA 0.74 17.25 0.69 3.99e-48 Obesity-related traits; LUSC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11644478 chr21:40555479 PSMG1 0.93 18.05 0.7 2.67e-51 Cognitive function; LUSC cis rs72480748 0.509 rs3865457 chr19:41398969 C/T cg04176888 chr19:41596066 CYP2A13 0.47 8.49 0.42 6.8e-16 Post bronchodilator FEV1;Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio); LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.61e-8 Diabetic kidney disease; LUSC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg12639453 chr1:2035780 PRKCZ -0.34 -7.29 -0.37 2.26e-12 Height; LUSC cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg08999081 chr20:33150536 PIGU 0.44 8.01 0.4 1.99e-14 Coronary artery disease; LUSC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg12292205 chr6:26970375 C6orf41 0.51 8.55 0.42 4.64e-16 Schizophrenia; LUSC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.86 -0.47 2.63e-20 Gut microbiome composition (summer); LUSC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg25456477 chr12:86230367 RASSF9 0.44 7.88 0.4 4.75e-14 Major depressive disorder; LUSC cis rs977987 0.806 rs12599361 chr16:75434973 A/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.84 -0.35 3.75e-11 Dupuytren's disease; LUSC cis rs12980942 1.000 rs12972266 chr19:41810771 G/A cg25627403 chr19:41769009 HNRNPUL1 0.57 6.16 0.32 2.05e-9 Coronary artery disease; LUSC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg20135002 chr11:47629003 NA -0.52 -8.08 -0.4 1.17e-14 Subjective well-being; LUSC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg17971929 chr21:40555470 PSMG1 0.53 8.35 0.42 1.85e-15 Cognitive function; LUSC trans rs561341 1.000 rs693116 chr17:30246124 C/T cg27661571 chr11:113659931 NA -0.66 -7.52 -0.38 5.2e-13 Hip circumference adjusted for BMI; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.87 -12.37 -0.56 3.29e-29 Platelet count; LUSC cis rs9921338 0.961 rs7193278 chr16:11445831 A/C cg00044050 chr16:11439710 C16orf75 -0.51 -6.7 -0.34 9e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs9303401 0.659 rs12150264 chr17:56939927 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.18 0.58 3.19e-32 Cognitive test performance; LUSC cis rs17270561 0.609 rs4464787 chr6:25733558 G/C cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.35e-17 Iron status biomarkers; LUSC cis rs1113500 0.933 rs3893034 chr1:108632178 G/A cg11967332 chr1:108735228 SLC25A24 0.38 5.76 0.3 1.92e-8 Growth-regulated protein alpha levels; LUSC cis rs3806843 0.576 rs246036 chr5:140331886 T/G cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1953600 0.870 rs2236557 chr10:81923961 A/G cg00277334 chr10:82204260 NA 0.43 6.68 0.34 1.02e-10 Sarcoidosis; LUSC cis rs3820068 0.506 rs17448966 chr1:15990983 T/G cg13390004 chr1:15929781 NA 0.4 6.89 0.35 2.72e-11 Systolic blood pressure; LUSC cis rs4631830 0.900 rs4630241 chr10:51532751 G/A cg10326726 chr10:51549505 MSMB -0.38 -6.57 -0.34 1.93e-10 Prostate-specific antigen levels; LUSC cis rs12310956 0.510 rs11612987 chr12:33879130 T/C cg06521331 chr12:34319734 NA -0.37 -6.16 -0.32 2.06e-9 Morning vs. evening chronotype; LUSC cis rs73129298 0.551 rs8125976 chr20:48599020 T/C cg25655593 chr20:48599521 SNAI1 0.59 6.37 0.33 6.36e-10 Inflammatory skin disease; LUSC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.29 0.49 9.44e-22 Monocyte percentage of white cells; LUSC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg07806771 chr7:64541737 NA -0.41 -5.87 -0.31 1.07e-8 Calcium levels; LUSC cis rs7106204 0.748 rs12293729 chr11:24224679 A/G ch.11.24196551F chr11:24239977 NA 1.13 14.37 0.62 8.42e-37 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg04553112 chr3:125709451 NA -0.51 -5.78 -0.3 1.76e-8 Blood pressure (smoking interaction); LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg22166914 chr1:53195759 ZYG11B -0.49 -7.65 -0.39 2.23e-13 Monocyte count; LUSC cis rs2857891 0.817 rs2638096 chr11:6977916 T/A cg14883916 chr11:6947541 ZNF215 0.45 5.85 0.31 1.15e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs7546094 0.509 rs7415988 chr1:113159730 G/T cg22162597 chr1:113214053 CAPZA1 -0.7 -10.0 -0.48 9.24e-21 Platelet distribution width; LUSC cis rs501916 1.000 rs648627 chr15:48055738 C/T cg16110827 chr15:48056943 SEMA6D -0.34 -5.75 -0.3 1.99e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg26314531 chr2:26401878 FAM59B 0.75 10.15 0.49 2.9e-21 Mean corpuscular hemoglobin; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03342130 chr1:244211790 NA -0.42 -6.08 -0.32 3.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg02527881 chr3:46936655 PTH1R -0.43 -7.84 -0.39 6.16e-14 Colorectal cancer; LUSC cis rs1775715 0.870 rs11008696 chr10:32218614 G/A cg03015672 chr10:32216066 ARHGAP12 0.32 5.75 0.3 1.97e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 9.32 0.45 1.6e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs2898290 0.622 rs7829381 chr8:11344573 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.37 -0.42 1.6e-15 Systolic blood pressure; LUSC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg24838063 chr12:130822603 PIWIL1 -0.7 -10.79 -0.51 1.7e-23 Menopause (age at onset); LUSC cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg22676075 chr6:135203613 NA 0.59 9.48 0.46 5e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg23711669 chr6:146136114 FBXO30 0.82 14.67 0.63 6.12e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.12 0.32 2.56e-9 Platelet count; LUSC cis rs11264799 0.603 rs12730818 chr1:157575630 T/A cg18268488 chr1:157545234 FCRL4 0.36 6.44 0.33 4.18e-10 IgA nephropathy; LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg23758822 chr17:41437982 NA 1.05 20.03 0.74 3.41e-59 Menopause (age at onset); LUSC cis rs7091068 0.574 rs10748610 chr10:95462235 C/G cg20715218 chr10:95462985 C10orf4 0.65 7.47 0.38 6.99e-13 Urinary tract infection frequency; LUSC cis rs9486719 1.000 rs12214469 chr6:97019471 G/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.98 -0.48 1.1e-20 Migraine;Coronary artery disease; LUSC cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg24642439 chr20:33292090 TP53INP2 -0.49 -7.36 -0.37 1.47e-12 Glomerular filtration rate (creatinine); LUSC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg18827107 chr12:86230957 RASSF9 0.46 6.95 0.36 1.94e-11 Major depressive disorder; LUSC trans rs7615952 0.599 rs1875683 chr3:125732481 C/G cg07211511 chr3:129823064 LOC729375 -0.81 -10.7 -0.51 3.52e-23 Blood pressure (smoking interaction); LUSC cis rs3126085 0.935 rs10888475 chr1:152226012 C/T cg26876637 chr1:152193138 HRNR 0.44 6.38 0.33 5.75e-10 Atopic dermatitis; LUSC cis rs10504229 0.636 rs114725691 chr8:58054292 C/T cg22535103 chr8:58192502 C8orf71 -0.58 -6.63 -0.34 1.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs34172651 0.917 rs172066 chr16:24756449 C/T cg00339695 chr16:24857497 SLC5A11 0.34 5.81 0.3 1.46e-8 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg08564027 chr20:61660810 NA 0.9 17.04 0.68 2.82e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs6596100 0.500 rs58840150 chr5:132248041 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Breast cancer; LUSC cis rs11031096 0.655 rs12275560 chr11:4211564 T/C cg18678763 chr11:4115507 RRM1 -0.41 -5.71 -0.3 2.5e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11758351 0.734 rs56220351 chr6:26206884 A/G cg23601095 chr6:26197514 HIST1H3D 0.7 7.6 0.38 2.96e-13 Gout;Renal underexcretion gout; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17937102 chr1:165667565 ALDH9A1 0.42 6.48 0.33 3.23e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs17125944 0.615 rs12586707 chr14:53298277 A/G cg00686598 chr14:53173677 PSMC6 -0.68 -6.27 -0.32 1.12e-9 Alzheimer's disease (late onset); LUSC cis rs62064224 0.702 rs735555 chr17:30817450 A/G cg15785704 chr17:30669010 C17orf75 0.43 6.63 0.34 1.35e-10 Schizophrenia; LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 13.93 0.61 4.14e-35 Platelet count; LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg07395648 chr5:131743802 NA 0.42 6.01 0.31 4.97e-9 Breast cancer; LUSC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg06618935 chr21:46677482 NA -0.39 -7.91 -0.4 3.73e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs941408 1.000 rs1736179 chr19:2795516 T/A cg19676328 chr12:49525230 TUBA1B -0.51 -8.28 -0.41 2.94e-15 Total cholesterol levels; LUSC cis rs1577917 0.816 rs1838952 chr6:86601144 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.35 -0.33 7.09e-10 Response to antipsychotic treatment; LUSC cis rs9309711 0.883 rs13429373 chr2:3477014 G/A cg10845886 chr2:3471009 TTC15 -0.65 -8.32 -0.41 2.26e-15 Neurofibrillary tangles; LUSC cis rs6723226 0.766 rs398290 chr2:32503526 T/C cg02381751 chr2:32503542 YIPF4 0.65 9.58 0.46 2.29e-19 Intelligence (multi-trait analysis); LUSC cis rs12579753 0.879 rs10778828 chr12:82117216 C/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.14 -0.32 2.39e-9 Resting heart rate; LUSC cis rs113835537 0.529 rs11550299 chr11:66254085 G/T cg24851651 chr11:66362959 CCS 0.54 8.02 0.4 1.77e-14 Airway imaging phenotypes; LUSC cis rs6714710 0.603 rs34503448 chr2:98587288 A/G cg26665480 chr2:98280029 ACTR1B 0.61 8.79 0.43 8.12e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.78 -0.3 1.71e-8 Vitiligo; LUSC cis rs4665809 0.590 rs11126339 chr2:26253223 T/C cg27170947 chr2:26402098 FAM59B -0.53 -7.54 -0.38 4.51e-13 Gut microbiome composition (summer); LUSC cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg16586182 chr3:47516702 SCAP 0.56 8.77 0.43 9.41e-17 Colorectal cancer; LUSC cis rs10904908 0.733 rs359299 chr10:17334378 G/A cg01003015 chr10:17271136 VIM 0.43 6.04 0.31 4.18e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg09184832 chr6:79620586 NA -0.44 -7.17 -0.37 4.75e-12 Intelligence (multi-trait analysis); LUSC cis rs6920965 0.509 rs575811 chr6:126162282 T/C cg05901451 chr6:126070800 HEY2 0.4 5.65 0.3 3.46e-8 High light scatter reticulocyte count; LUSC cis rs367943 0.966 rs444322 chr5:112815399 C/T cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg18196295 chr10:418757 DIP2C 0.43 7.05 0.36 1e-11 Psychosis in Alzheimer's disease; LUSC cis rs3764563 0.877 rs4019751 chr19:15740716 T/G cg20725493 chr19:15740067 CYP4F8 -0.64 -6.62 -0.34 1.44e-10 Inflammatory biomarkers; LUSC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg06238570 chr21:40685208 BRWD1 0.49 7.37 0.37 1.37e-12 Cognitive function; LUSC cis rs35883536 0.514 rs4908062 chr1:101013211 T/C cg06223162 chr1:101003688 GPR88 0.48 8.92 0.44 3.02e-17 Monocyte count; LUSC cis rs3733418 0.929 rs13149062 chr4:165905360 T/G cg11630554 chr4:165878136 TRIM61;C4orf39 -0.51 -5.84 -0.3 1.25e-8 Obesity-related traits; LUSC cis rs8062405 1.000 rs72793812 chr16:28840381 A/G cg05966235 chr16:28915196 ATP2A1 0.33 5.83 0.3 1.32e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg15744005 chr10:104629667 AS3MT -0.27 -5.68 -0.3 2.93e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs701145 0.878 rs355753 chr3:153968846 T/C cg17054900 chr3:154042577 DHX36 0.85 9.0 0.44 1.75e-17 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26665246 chr5:179105570 CBY3 -0.6 -7.41 -0.38 1.05e-12 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.95 -0.36 1.97e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg00745463 chr17:30367425 LRRC37B 0.78 8.66 0.43 2.06e-16 Hip circumference adjusted for BMI; LUSC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg18252515 chr7:66147081 NA -0.39 -5.66 -0.3 3.22e-8 Aortic root size; LUSC cis rs6964587 1.000 rs11982213 chr7:91722966 A/G cg17063962 chr7:91808500 NA 0.59 9.25 0.45 2.65e-18 Breast cancer; LUSC cis rs5167 0.566 rs934427 chr19:45478816 T/G cg13119609 chr19:45449297 APOC2 0.35 5.79 0.3 1.63e-8 Blood protein levels; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg10360139 chr7:1886902 MAD1L1 -0.46 -7.14 -0.36 5.82e-12 Bipolar disorder and schizophrenia; LUSC cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg12219531 chr12:120966889 COQ5 0.6 8.15 0.41 7.42e-15 High light scatter reticulocyte count; LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.89 0.31 9.34e-9 Menopause (age at onset); LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg10729496 chr3:10149963 C3orf24 0.52 6.96 0.36 1.76e-11 Alzheimer's disease; LUSC cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs9341808 0.667 rs2490241 chr6:80846342 T/C cg08355045 chr6:80787529 NA 0.47 8.18 0.41 5.96e-15 Sitting height ratio; LUSC cis rs7940866 0.838 rs7122268 chr11:130892029 A/T cg12179176 chr11:130786555 SNX19 0.61 9.72 0.47 7.8500000000000006e-20 Schizophrenia; LUSC cis rs2439831 0.681 rs11858152 chr15:43634196 T/C cg02155558 chr15:43621948 ADAL;LCMT2 1.09 15.23 0.64 3.79e-40 Lung cancer in ever smokers; LUSC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg18190219 chr22:46762943 CELSR1 -0.54 -6.02 -0.31 4.61e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg11344533 chr11:111475393 SIK2 0.47 6.23 0.32 1.38e-9 Primary sclerosing cholangitis; LUSC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg06634786 chr22:41940651 POLR3H -0.56 -6.54 -0.34 2.29e-10 Vitiligo; LUSC cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg26395211 chr5:140044315 WDR55 0.46 7.16 0.36 5.08e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs4423214 1.000 rs2282621 chr11:71183474 C/T cg05163923 chr11:71159392 DHCR7 0.78 11.49 0.53 5.51e-26 Vitamin D levels; LUSC cis rs68170813 0.559 rs7807648 chr7:106965091 C/T cg02696742 chr7:106810147 HBP1 -0.63 -9.1 -0.45 8.52e-18 Coronary artery disease; LUSC cis rs2559856 1.000 rs2695298 chr12:102082589 G/A cg12924262 chr12:102091054 CHPT1 0.42 5.84 0.3 1.24e-8 Blood protein levels; LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10838798 0.584 rs1566732 chr11:48151494 A/C cg18512352 chr11:47633146 NA 0.28 5.7 0.3 2.69e-8 Height; LUSC cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg24642439 chr20:33292090 TP53INP2 -0.55 -8.21 -0.41 4.83e-15 Coronary artery disease; LUSC cis rs2708977 0.933 rs6576972 chr2:97152446 C/T cg01950434 chr2:97203154 ARID5A -0.53 -8.06 -0.4 1.41e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.19 0.41 5.52e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg11764359 chr7:65958608 NA -0.7 -10.95 -0.51 4.95e-24 Aortic root size; LUSC cis rs9303401 0.659 rs62083410 chr17:56964386 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.54 0.6 1.33e-33 Cognitive test performance; LUSC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg00484396 chr16:3507460 NAT15 0.73 12.49 0.56 1.2e-29 Tuberculosis; LUSC cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg09184832 chr6:79620586 NA -0.42 -6.83 -0.35 3.96e-11 Intelligence (multi-trait analysis); LUSC cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.38 -0.37 1.23e-12 Psoriasis; LUSC cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg23158103 chr7:148848205 ZNF398 -0.42 -6.62 -0.34 1.46e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg20891558 chr2:74357851 NA 0.79 14.33 0.62 1.24e-36 Gestational age at birth (maternal effect); LUSC cis rs9648716 0.515 rs75486053 chr7:140495583 A/C cg23214464 chr7:140373596 ADCK2 0.67 5.65 0.3 3.41e-8 Type 2 diabetes; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg12432903 chr7:1882776 MAD1L1 -0.39 -6.31 -0.33 8.83e-10 Bipolar disorder and schizophrenia; LUSC cis rs9814567 1.000 rs11928499 chr3:134232350 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.95 0.61 3.51e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs338389 0.586 rs338402 chr15:68253951 C/T cg16317052 chr17:61678891 TACO1 0.38 5.95 0.31 6.89e-9 Survival in rectal cancer; LUSC cis rs11098499 0.954 rs17006190 chr4:120418838 C/G cg24375607 chr4:120327624 NA 0.79 11.99 0.55 8.46e-28 Corneal astigmatism; LUSC cis rs9815354 1.000 rs1717020 chr3:41981490 A/C cg03022575 chr3:42003672 ULK4 0.54 5.9 0.31 8.78e-9 Pulse pressure;Diastolic blood pressure; LUSC trans rs1814175 0.645 rs28454367 chr11:50045708 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs9549367 0.713 rs11620600 chr13:113829090 G/A cg18105134 chr13:113819100 PROZ -0.76 -10.76 -0.51 2.21e-23 Platelet distribution width; LUSC cis rs11648785 0.590 rs10431948 chr16:90099571 A/G cg16611967 chr16:90144006 NA -0.4 -5.79 -0.3 1.66e-8 Tanning; LUSC cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg08999081 chr20:33150536 PIGU -0.41 -7.68 -0.39 1.79e-13 Glomerular filtration rate (creatinine); LUSC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg02380750 chr20:61661411 NA -0.34 -5.91 -0.31 8.4e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9300255 0.512 rs2851436 chr12:123667354 G/T cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.48 -0.33 3.22e-10 Neutrophil percentage of white cells; LUSC trans rs9693857 0.520 rs4841163 chr8:9366178 C/G cg06636001 chr8:8085503 FLJ10661 0.45 6.55 0.34 2.11e-10 Systolic blood pressure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04407776 chr1:84465009 TTLL7 0.46 6.73 0.35 7.4e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3820928 0.839 rs4673174 chr2:227801316 A/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.14e-13 Pulmonary function; LUSC cis rs78456975 1.000 rs11883965 chr2:1560062 T/C cg01028140 chr2:1542097 TPO -0.6 -8.23 -0.41 4.32e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs950169 0.649 rs12905952 chr15:84691261 G/A cg11189052 chr15:85197271 WDR73 0.54 6.13 0.32 2.42e-9 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21925064 chr5:148724958 GRPEL2 -0.41 -6.31 -0.33 8.81e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs981844 0.712 rs4616729 chr4:154746900 T/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC trans rs7230711 1.000 rs17737030 chr18:48775644 C/T cg03733578 chr1:18809059 KLHDC7A 0.48 6.07 0.32 3.54e-9 Immune response to anthrax vaccine; LUSC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg24257776 chr3:47051546 LOC100129354 0.33 5.89 0.31 9.32e-9 Colorectal cancer; LUSC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.78 -0.35 5.6e-11 Tonsillectomy; LUSC cis rs4363385 0.818 rs6661791 chr1:152994113 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.79 -0.3 1.63e-8 Inflammatory skin disease; LUSC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg07424592 chr7:64974309 NA 0.69 6.19 0.32 1.81e-9 Diabetic kidney disease; LUSC cis rs137603 0.644 rs137635 chr22:39720656 G/C cg17798944 chr22:39715225 SNORD43;RPL3 -0.52 -8.38 -0.42 1.54e-15 Primary biliary cholangitis; LUSC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg11608241 chr8:8085544 FLJ10661 0.4 5.85 0.31 1.14e-8 Mood instability; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg00166722 chr3:10149974 C3orf24 0.62 8.64 0.43 2.36e-16 Alzheimer's disease; LUSC cis rs2455601 0.882 rs11042118 chr11:8928791 T/A cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -7.8 -0.39 7.98e-14 Schizophrenia; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg07677032 chr17:61819896 STRADA 0.54 9.06 0.44 1.15e-17 Prudent dietary pattern; LUSC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg13607699 chr17:42295918 UBTF 0.49 7.64 0.39 2.39e-13 Total body bone mineral density; LUSC cis rs2204008 0.807 rs4123933 chr12:37973539 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.94 0.66 5.93e-43 Bladder cancer; LUSC cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg26597838 chr10:835615 NA -0.45 -6.12 -0.32 2.6e-9 Response to angiotensin II receptor blocker therapy; LUSC cis rs2455601 0.507 rs2568044 chr11:9002477 T/C cg09997546 chr11:8931473 C11orf17;ST5 0.35 6.15 0.32 2.18e-9 Schizophrenia; LUSC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg26566898 chr11:117069891 TAGLN -0.43 -7.49 -0.38 6.06e-13 Blood protein levels; LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg08888203 chr3:10149979 C3orf24 0.6 8.48 0.42 7.35e-16 Alzheimer's disease; LUSC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg18876405 chr7:65276391 NA -0.59 -9.55 -0.46 2.9e-19 Aortic root size; LUSC trans rs9929218 1.000 rs4783570 chr16:68806539 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -11.75 -0.54 6.51e-27 Colorectal cancer; LUSC cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg05855489 chr10:104503620 C10orf26 -0.68 -9.85 -0.47 2.9e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12368653 0.641 rs11172300 chr12:58076515 C/T cg18357645 chr12:58087776 OS9 0.38 5.65 0.3 3.49e-8 Multiple sclerosis; LUSC cis rs2760061 0.583 rs697763 chr1:228192622 G/C cg18477163 chr1:228402036 OBSCN 0.57 9.59 0.46 2.12e-19 Diastolic blood pressure; LUSC cis rs7020830 0.789 rs17408112 chr9:37114065 A/G cg14294708 chr9:37120828 ZCCHC7 1.1 25.33 0.81 9.63e-80 Schizophrenia; LUSC cis rs425277 0.628 rs3128340 chr1:2047496 C/G cg12639453 chr1:2035780 PRKCZ -0.31 -6.51 -0.34 2.75e-10 Height; LUSC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg08564027 chr20:61660810 NA 0.91 17.35 0.69 1.58e-48 Prostate cancer (SNP x SNP interaction); LUSC trans rs524023 0.914 rs2666559 chr11:64439227 G/T cg17873998 chr1:200117089 NR5A2 -0.39 -6.13 -0.32 2.54e-9 Urate levels in obese individuals; LUSC cis rs11637445 0.677 rs4539549 chr15:68070619 C/T cg08079166 chr15:68083412 MAP2K5 0.36 7.32 0.37 1.89e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs7568458 0.660 rs6547623 chr2:85801964 T/A cg17127132 chr2:85788382 GGCX 0.42 6.03 0.31 4.3e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg00343986 chr7:65444356 GUSB 0.5 7.69 0.39 1.65e-13 Aortic root size; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg08888203 chr3:10149979 C3orf24 0.63 9.09 0.45 8.92e-18 Alzheimer's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09418283 chr12:80084718 PAWR -0.39 -6.05 -0.31 3.9e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2124969 0.562 rs4665164 chr2:161070078 T/G cg03641300 chr2:160917029 PLA2R1 -0.44 -7.12 -0.36 6.75e-12 Waist circumference adjusted for body mass index; LUSC cis rs2439831 0.850 rs7183809 chr15:44120868 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.84 8.34 0.42 1.92e-15 Lung cancer in ever smokers; LUSC cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg06784218 chr1:46089804 CCDC17 -0.56 -11.07 -0.52 1.85e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg15790184 chr11:494944 RNH1 0.5 7.52 0.38 5.21e-13 Systemic lupus erythematosus; LUSC cis rs1005224 0.889 rs2059382 chr14:76158916 T/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.68 -9.23 -0.45 3.1e-18 Large artery stroke; LUSC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.03 -0.31 4.23e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg07703079 chr11:430292 ANO9 0.6 6.39 0.33 5.6e-10 Body mass index; LUSC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.76 0.39 1.02e-13 Parkinson's disease; LUSC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg20891283 chr12:69753455 YEATS4 0.83 14.72 0.63 3.75e-38 Blood protein levels; LUSC cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg26408565 chr15:76604113 ETFA -0.43 -6.82 -0.35 4.4e-11 Blood metabolite levels; LUSC cis rs12618769 0.652 rs17513468 chr2:99235169 T/G cg10123293 chr2:99228465 UNC50 0.47 7.55 0.38 4.22e-13 Bipolar disorder; LUSC cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg23788917 chr6:8435910 SLC35B3 0.51 7.57 0.38 3.75e-13 Motion sickness; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg06873352 chr17:61820015 STRADA 0.72 12.6 0.57 4.64e-30 Prudent dietary pattern; LUSC cis rs174479 0.647 rs174457 chr11:61656975 T/C cg01500311 chr11:61656094 FADS3 0.4 7.06 0.36 9.65e-12 Sphingolipid levels; LUSC cis rs8017423 0.935 rs17260827 chr14:90732703 G/A cg04374321 chr14:90722782 PSMC1 -0.68 -10.3 -0.49 8.52e-22 Mortality in heart failure; LUSC cis rs6426558 0.621 rs7521639 chr1:227223736 T/C cg10327440 chr1:227177885 CDC42BPA 0.88 16.04 0.66 2.51e-43 Neutrophil percentage of white cells; LUSC trans rs747782 0.528 rs624348 chr11:48400795 G/A cg15704280 chr7:45808275 SEPT13 -0.68 -6.43 -0.33 4.36e-10 Intraocular pressure; LUSC cis rs1044826 0.642 rs9833307 chr3:139181370 G/A cg00490450 chr3:139108681 COPB2 0.45 6.98 0.36 1.56e-11 Obesity-related traits; LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg02772935 chr3:125709198 NA -0.5 -5.99 -0.31 5.3300000000000004e-09 Blood pressure (smoking interaction); LUSC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg00033643 chr7:134001901 SLC35B4 0.47 7.28 0.37 2.36e-12 Mean platelet volume; LUSC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg27535305 chr1:53392650 SCP2 0.33 5.95 0.31 6.6e-9 Monocyte count; LUSC cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg21535247 chr6:8435926 SLC35B3 0.55 8.48 0.42 7.63e-16 Motion sickness; LUSC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg10755058 chr3:40428713 ENTPD3 0.36 5.97 0.31 5.99e-9 Renal cell carcinoma; LUSC cis rs72960926 0.744 rs4282374 chr6:74899318 T/C cg03266952 chr6:74778945 NA -0.76 -6.05 -0.31 3.85e-9 Metabolite levels (MHPG); LUSC cis rs939574 1.000 rs11552796 chr2:220108300 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.09 8.72 0.43 1.31e-16 Platelet distribution width; LUSC cis rs6754311 0.593 rs313524 chr2:136444123 C/T cg07169764 chr2:136633963 MCM6 0.55 7.29 0.37 2.32e-12 Mosquito bite size; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg16325326 chr1:53192061 ZYG11B 0.7 11.49 0.53 5.47e-26 Monocyte count; LUSC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg11247378 chr22:39784982 NA -0.61 -10.94 -0.51 5.23e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs61931739 0.890 rs694706 chr12:34135323 T/C cg13010199 chr12:38710504 ALG10B 0.44 6.93 0.35 2.21e-11 Morning vs. evening chronotype; LUSC cis rs11051970 0.611 rs10844197 chr12:32561015 A/C cg02745156 chr12:32552066 NA 0.38 6.81 0.35 4.59e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2798269 0.966 rs17679426 chr13:22122477 A/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.09 -0.32 3.19e-9 PR segment; LUSC cis rs34330 0.562 rs11055024 chr12:12858969 A/G cg09462578 chr12:12878428 APOLD1 -0.68 -7.89 -0.4 4.41e-14 Systemic lupus erythematosus; LUSC trans rs2243480 1.000 rs4718309 chr7:65627764 G/C cg10756647 chr7:56101905 PSPH -0.84 -8.39 -0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs1018836 0.923 rs2187982 chr8:91556317 G/T cg16814680 chr8:91681699 NA -0.75 -12.79 -0.57 9.26e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs1005277 0.579 rs1985707 chr10:38434098 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.59 -0.46 2.1e-19 Extrinsic epigenetic age acceleration; LUSC trans rs62458065 0.850 rs62458099 chr7:32472395 C/T cg00845942 chr12:64062724 DPY19L2 -0.53 -6.08 -0.32 3.33e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs8078723 0.510 rs3859189 chr17:38137033 A/G cg17467752 chr17:38218738 THRA -0.53 -7.87 -0.4 4.97e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg19592336 chr6:28129416 ZNF389 0.46 6.01 0.31 4.81e-9 Depression; LUSC cis rs3862030 0.694 rs2025712 chr10:104230064 T/C cg05855489 chr10:104503620 C10orf26 0.49 7.36 0.37 1.48e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg22906224 chr7:99728672 NA 0.49 6.81 0.35 4.55e-11 Coronary artery disease; LUSC cis rs77633900 0.772 rs157789 chr15:76805703 T/A cg21673338 chr15:77095150 SCAPER -0.71 -6.12 -0.32 2.65e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg12310025 chr6:25882481 NA -0.5 -8.55 -0.42 4.36e-16 Intelligence (multi-trait analysis); LUSC cis rs59698941 0.943 rs67160603 chr5:132285618 G/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs12760731 0.720 rs3791023 chr1:178398092 A/C cg00404053 chr1:178313656 RASAL2 0.57 6.23 0.32 1.39e-9 Obesity-related traits; LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg00149659 chr3:10157352 C3orf10 0.98 14.19 0.61 4.3e-36 Alzheimer's disease; LUSC trans rs2727020 0.514 rs4980444 chr11:49550764 T/A cg03929089 chr4:120376271 NA -0.94 -16.07 -0.66 1.96e-43 Coronary artery disease; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg05064044 chr6:292385 DUSP22 -0.51 -7.46 -0.38 7.57e-13 Menopause (age at onset); LUSC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg22968622 chr17:43663579 NA 0.8 12.25 0.56 9.6e-29 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.45 1.43e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg24060327 chr5:131705240 SLC22A5 -0.47 -8.35 -0.42 1.87e-15 Blood metabolite levels; LUSC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.81 0.39 7.69e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2235649 0.833 rs7189070 chr16:1850813 G/A cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.44 -5.97 -0.31 6.06e-9 Blood metabolite levels; LUSC cis rs208520 0.742 rs208454 chr6:66907783 T/C cg07460842 chr6:66804631 NA -0.96 -12.87 -0.58 4.54e-31 Exhaled nitric oxide output; LUSC cis rs72772090 0.908 rs17086588 chr5:96044914 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.62 7.29 0.37 2.28e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11229555 0.645 rs6591475 chr11:58193551 G/T cg15696309 chr11:58395628 NA 0.64 7.9 0.4 3.97e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7615952 0.932 rs11922218 chr3:125631289 C/T cg05084668 chr3:125655381 ALG1L -0.78 -11.57 -0.53 2.84e-26 Blood pressure (smoking interaction); LUSC cis rs12220238 1.000 rs10824102 chr10:75948915 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.88 0.35 2.93e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs17014483 0.749 rs2972030 chr4:89631029 A/G cg01026744 chr4:89619053 NAP1L5;HERC3 0.68 5.97 0.31 5.92e-9 Post bronchodilator FEV1/FVC ratio; LUSC trans rs3960554 0.808 rs2286829 chr7:75677739 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 9.53 0.46 3.45e-19 Eotaxin levels; LUSC cis rs3808502 0.525 rs13280813 chr8:11425105 G/T cg21775007 chr8:11205619 TDH -0.54 -7.68 -0.39 1.74e-13 Neuroticism; LUSC cis rs7572733 0.534 rs700688 chr2:198723833 A/G cg00792783 chr2:198669748 PLCL1 -0.43 -5.88 -0.31 9.78e-9 Dermatomyositis; LUSC cis rs35000415 0.938 rs17338998 chr7:128618559 C/T cg19972273 chr7:128594194 NA 0.68 6.9 0.35 2.56e-11 Systemic lupus erythematosus; LUSC cis rs191220855 1 rs191220855 chr2:200778130 A/G cg23649088 chr2:200775458 C2orf69 -0.59 -7.1 -0.36 7.73e-12 Chickenpox; LUSC cis rs8048589 0.558 rs34565142 chr16:12231347 C/T cg02910054 chr16:12241554 SNX29 0.45 5.82 0.3 1.42e-8 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs6831352 0.819 rs896992 chr4:100002372 C/T cg12011299 chr4:100065546 ADH4 0.67 10.5 0.5 1.75e-22 Alcohol dependence; LUSC cis rs2573652 1.000 rs11634977 chr15:100516472 G/A cg09918751 chr15:100517450 ADAMTS17 -0.47 -8.87 -0.44 4.46e-17 Height; LUSC cis rs4478137 0.824 rs10857353 chr4:164215835 A/G cg06758707 chr4:164254230 NPY1R -0.59 -9.2 -0.45 4.04e-18 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC trans rs7824557 0.527 rs57629785 chr8:11235150 C/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.76 -0.39 1.06e-13 Retinal vascular caliber; LUSC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg19230755 chr7:65878503 NA 0.43 6.06 0.31 3.67e-9 Aortic root size; LUSC cis rs7677751 0.848 rs4635872 chr4:55099041 C/A cg17187183 chr4:55093834 PDGFRA 0.39 5.82 0.3 1.41e-8 Corneal astigmatism; LUSC cis rs4845570 0.850 rs4618976 chr1:151766588 A/G cg07092448 chr1:151763213 TDRKH 1.27 15.12 0.64 9.92e-40 Coronary artery disease; LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg07507251 chr3:52567010 NT5DC2 0.32 6.11 0.32 2.7e-9 Bipolar disorder; LUSC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg06112835 chr11:68658793 MRPL21 -0.48 -7.42 -0.38 9.57e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg06784218 chr1:46089804 CCDC17 0.54 10.93 0.51 5.59e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26496917 chr22:38668929 TMEM184B 0.44 6.17 0.32 1.93e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg22681709 chr2:178499509 PDE11A -0.51 -9.15 -0.45 5.67e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9549260 0.564 rs8000965 chr13:41279488 C/T cg21288729 chr13:41239152 FOXO1 0.55 8.42 0.42 1.12e-15 Red blood cell count; LUSC cis rs4356932 1.000 rs4241579 chr4:76947284 A/G cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg07936489 chr17:37558343 FBXL20 -0.72 -9.91 -0.48 1.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs1385374 0.841 rs11059929 chr12:129296893 G/A cg09035930 chr12:129282057 SLC15A4 -0.64 -6.57 -0.34 1.97e-10 Systemic lupus erythematosus; LUSC cis rs4964805 0.954 rs10861104 chr12:104189923 A/C cg02344784 chr12:104178138 NT5DC3 0.43 6.71 0.34 8.11e-11 Attention deficit hyperactivity disorder; LUSC cis rs9527 0.545 rs7894588 chr10:104756030 A/T cg05855489 chr10:104503620 C10orf26 0.51 7.47 0.38 7.17e-13 Arsenic metabolism; LUSC cis rs12681287 0.640 rs7007855 chr8:87429491 T/G cg27223183 chr8:87520930 FAM82B 0.54 7.45 0.38 7.84e-13 Caudate activity during reward; LUSC cis rs765787 0.530 rs12440321 chr15:45529385 G/A cg25801113 chr15:45476975 SHF -0.35 -6.9 -0.35 2.59e-11 Uric acid levels; LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg13397359 chr6:42928475 GNMT 0.68 12.0 0.55 7.83e-28 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg25019033 chr10:957182 NA -0.46 -5.77 -0.3 1.79e-8 Eosinophil percentage of granulocytes; LUSC cis rs977987 0.806 rs12051326 chr16:75437887 G/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.79e-10 Dupuytren's disease; LUSC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.44 5.94 0.31 7.13e-9 Renal function-related traits (BUN); LUSC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg26677194 chr12:130822605 PIWIL1 0.59 8.77 0.43 9.52e-17 Menopause (age at onset); LUSC cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg26384229 chr12:38710491 ALG10B 0.84 14.43 0.62 5.19e-37 Bladder cancer; LUSC trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg15704280 chr7:45808275 SEPT13 -0.46 -6.34 -0.33 7.57e-10 HDL cholesterol; LUSC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg22862634 chr11:62369728 EML3;MTA2 0.59 9.33 0.45 1.46e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18301423 chr5:131593218 PDLIM4 0.47 7.31 0.37 2.05e-12 Acylcarnitine levels; LUSC cis rs2692947 0.644 rs1168974 chr2:96814928 G/A cg23100626 chr2:96804247 ASTL 0.3 7.08 0.36 8.56e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -11.29 -0.53 2.85e-25 Systemic lupus erythematosus; LUSC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.48e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC trans rs561341 0.556 rs542244 chr17:30307242 T/C cg20587970 chr11:113659929 NA -1.27 -17.49 -0.69 4.55e-49 Hip circumference adjusted for BMI; LUSC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg07936489 chr17:37558343 FBXL20 -0.71 -9.75 -0.47 6.1e-20 Glomerular filtration rate (creatinine); LUSC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg18099408 chr3:52552593 STAB1 -0.33 -5.65 -0.3 3.4e-8 Electroencephalogram traits; LUSC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -7.85 -0.39 5.59e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs590121 0.876 rs652054 chr11:75275532 C/A cg26104986 chr11:75275303 SERPINH1 -0.28 -5.75 -0.3 2.01e-8 Coronary artery disease; LUSC cis rs9467773 0.620 rs2504571 chr6:26643435 C/T cg11502198 chr6:26597334 ABT1 0.68 11.28 0.53 3.09e-25 Intelligence (multi-trait analysis); LUSC trans rs4948088 1.000 rs2329566 chr7:51017655 G/A cg26816907 chr1:197890812 LHX9 0.56 6.22 0.32 1.47e-9 Type 1 diabetes; LUSC cis rs58688157 0.705 rs7941547 chr11:611503 G/A cg01616529 chr11:638424 DRD4 -0.34 -5.98 -0.31 5.7e-9 Systemic lupus erythematosus; LUSC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg13319975 chr6:146136371 FBXO30 0.5 7.53 0.38 4.84e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg26587870 chr6:27730563 NA 0.54 5.96 0.31 6.41e-9 Depression; LUSC cis rs9296092 0.517 rs55963187 chr6:33523778 G/C cg13560919 chr6:33536144 NA -0.83 -15.75 -0.65 3.39e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs3099143 0.901 rs78020233 chr15:77107050 T/G cg21673338 chr15:77095150 SCAPER -0.77 -6.53 -0.34 2.5e-10 Recalcitrant atopic dermatitis; LUSC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg09323728 chr8:95962352 TP53INP1 -0.4 -8.11 -0.41 9.47e-15 Type 2 diabetes; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg23034840 chr1:205782522 SLC41A1 0.66 9.87 0.48 2.48e-20 Menarche (age at onset); LUSC cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg24558204 chr6:135376177 HBS1L -0.56 -8.14 -0.41 7.92e-15 Red blood cell count; LUSC cis rs11190604 1.000 rs2495754 chr10:102324812 C/T cg23241863 chr10:102295624 HIF1AN 0.5 5.71 0.3 2.53e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12477438 0.765 rs6542846 chr2:99563654 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.57 -0.57 6.18e-30 Chronic sinus infection; LUSC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg12311346 chr5:56204834 C5orf35 -0.84 -12.41 -0.56 2.46e-29 Initial pursuit acceleration; LUSC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg26695010 chr11:65641043 EFEMP2 0.41 5.75 0.3 2.03e-8 Breast cancer; LUSC cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.11e-14 Glomerular filtration rate (creatinine); LUSC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg24733560 chr20:60626293 TAF4 0.41 6.6 0.34 1.63e-10 Body mass index; LUSC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg22823121 chr1:150693482 HORMAD1 0.53 7.42 0.38 1.01e-12 Urate levels; LUSC cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg18876405 chr7:65276391 NA 0.48 6.53 0.34 2.49e-10 Corneal structure; LUSC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg04871131 chr7:94954202 PON1 -0.36 -5.65 -0.3 3.45e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg08859206 chr1:53392774 SCP2 -0.55 -9.56 -0.46 2.58e-19 Monocyte count; LUSC cis rs9925964 0.933 rs9929899 chr16:31062701 C/A cg02466173 chr16:30829666 NA 0.35 6.44 0.33 4.18e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21157115 chr9:33001303 APTX 0.37 6.06 0.31 3.77e-9 Triglycerides; LUSC cis rs7202877 0.706 rs37599 chr16:75502132 C/T cg03315344 chr16:75512273 CHST6 -0.42 -5.95 -0.31 6.74e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs2502731 0.539 rs3003609 chr9:130984755 A/G cg13642260 chr9:130955380 CIZ1 -0.48 -7.59 -0.38 3.27e-13 Attention deficit hyperactivity disorder; LUSC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg15448220 chr1:150897856 SETDB1 0.4 5.87 0.31 1.02e-8 Melanoma; LUSC cis rs9486719 0.857 rs2983897 chr6:97033780 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -12.19 -0.55 1.62e-28 Migraine;Coronary artery disease; LUSC cis rs2324229 0.828 rs1180226 chr6:83951709 G/A cg08257003 chr6:84140564 ME1 0.27 6.31 0.33 8.98e-10 Platelet-derived growth factor BB levels; LUSC cis rs921968 0.508 rs72965103 chr2:219312469 T/C cg02176678 chr2:219576539 TTLL4 -0.72 -13.56 -0.6 1.13e-33 Mean corpuscular hemoglobin concentration; LUSC cis rs469568 0.712 rs467604 chr5:178667984 A/G cg08999896 chr5:178685787 ADAMTS2 -0.28 -5.7 -0.3 2.64e-8 Stroke (pediatric); LUSC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg11764359 chr7:65958608 NA -0.68 -10.95 -0.51 4.81e-24 Aortic root size; LUSC cis rs763121 0.849 rs12004 chr22:38877461 T/G cg06022373 chr22:39101656 GTPBP1 0.76 11.5 0.53 5.33e-26 Menopause (age at onset); LUSC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs5758659 0.652 rs133321 chr22:42405322 A/G cg04733989 chr22:42467013 NAGA 0.39 6.62 0.34 1.45e-10 Cognitive function; LUSC cis rs9790314 1.000 rs4273380 chr3:160950314 A/G cg04691961 chr3:161091175 C3orf57 -0.34 -5.81 -0.3 1.49e-8 Morning vs. evening chronotype; LUSC cis rs427941 0.703 rs201452 chr7:101739663 C/T cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4462272 0.503 rs12774352 chr10:101840960 A/G cg02250046 chr10:101825185 CPN1 -0.3 -5.67 -0.3 3.14e-8 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2979489 0.891 rs4733495 chr8:30366883 A/G cg26383811 chr8:30366931 RBPMS 0.5 7.71 0.39 1.45e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg27588902 chr6:42928151 GNMT -0.29 -6.49 -0.33 3.11e-10 Plasma homocysteine levels (post-methionine load test); LUSC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg13114125 chr14:105738426 BRF1 -0.9 -15.79 -0.65 2.46e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs9790314 0.936 rs7629987 chr3:161002023 A/C cg04691961 chr3:161091175 C3orf57 -0.34 -5.83 -0.3 1.27e-8 Morning vs. evening chronotype; LUSC cis rs427941 0.694 rs2529094 chr7:101739617 C/T cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs9815354 1.000 rs3774372 chr3:41877414 A/G cg03022575 chr3:42003672 ULK4 0.66 7.17 0.37 4.77e-12 Pulse pressure;Diastolic blood pressure; LUSC cis rs9788682 1.000 rs34138960 chr15:78831668 A/G cg24631222 chr15:78858424 CHRNA5 0.85 11.44 0.53 8.6e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.3 0.49 8.36e-22 Schizophrenia; LUSC cis rs7605827 0.897 rs2890488 chr2:15635439 T/A cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.74e-17 Educational attainment (years of education); LUSC cis rs2439831 1.000 rs689647 chr15:43762196 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs60733400 0.817 rs4648657 chr1:2560735 A/G cg18932078 chr1:2524107 MMEL1 -0.31 -6.83 -0.35 4.11e-11 Multiple sclerosis; LUSC cis rs4555082 0.957 rs2816609 chr14:105720803 A/C cg06808227 chr14:105710500 BRF1 -0.67 -9.99 -0.48 9.89e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs4566357 1.000 rs1917129 chr2:227927951 A/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.91 -0.31 8.46e-9 Coronary artery disease; LUSC trans rs12145833 0.538 rs12026408 chr1:243366805 G/A cg01826367 chr1:224180288 NA 0.71 6.54 0.34 2.25e-10 Obesity (early onset extreme); LUSC cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg22618164 chr12:122356400 WDR66 -0.59 -8.77 -0.43 9.09e-17 Mean corpuscular volume; LUSC cis rs3007168 1.000 rs3007076 chr14:51605352 G/T cg23942311 chr14:51606299 NA 0.37 6.02 0.31 4.5e-9 Cancer; LUSC cis rs6964587 0.692 rs17672805 chr7:91573466 A/G cg17063962 chr7:91808500 NA -0.55 -9.12 -0.45 7.36e-18 Breast cancer; LUSC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.53 8.01 0.4 1.94e-14 Axial length; LUSC cis rs1448094 0.874 rs10779219 chr12:86322643 T/G cg02569458 chr12:86230093 RASSF9 0.42 6.81 0.35 4.67e-11 Major depressive disorder; LUSC cis rs10751667 0.600 rs4076915 chr11:1012464 C/G cg06064525 chr11:970664 AP2A2 -0.29 -5.68 -0.3 2.94e-8 Alzheimer's disease (late onset); LUSC cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14442939 chr10:27389572 ANKRD26 -0.88 -9.89 -0.48 2.12e-20 Breast cancer; LUSC trans rs2204008 0.594 rs11531211 chr12:37998007 T/G cg06521331 chr12:34319734 NA 0.4 6.29 0.33 1.02e-9 Bladder cancer; LUSC cis rs1499972 0.941 rs62263123 chr3:117632263 G/A cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.95e-8 Schizophrenia; LUSC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg17971929 chr21:40555470 PSMG1 0.68 11.22 0.52 5.13e-25 Cognitive function; LUSC cis rs6556937 0.597 rs7733671 chr5:96000269 A/G cg07690455 chr5:95997198 CAST -0.45 -6.14 -0.32 2.31e-9 Blood protein levels; LUSC cis rs11690935 0.851 rs7573003 chr2:172741415 T/A cg13550731 chr2:172543902 DYNC1I2 -0.81 -13.03 -0.58 1.17e-31 Schizophrenia; LUSC cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs11190604 1.000 rs11190587 chr10:102266638 C/T cg23241863 chr10:102295624 HIF1AN 0.49 5.7 0.3 2.69e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6815814 0.950 rs11727978 chr4:38811051 T/A cg02016764 chr4:38805732 TLR1 -0.54 -5.69 -0.3 2.81e-8 Breast cancer; LUSC trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs62400317 0.859 rs12153922 chr6:45256159 T/C cg20913747 chr6:44695427 NA -0.46 -7.47 -0.38 7.12e-13 Total body bone mineral density; LUSC cis rs2404602 0.647 rs11072607 chr15:76908529 C/T cg23625390 chr15:77176239 SCAPER -0.65 -9.95 -0.48 1.38e-20 Blood metabolite levels; LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg00814883 chr7:100076585 TSC22D4 -0.77 -9.7 -0.47 9.3e-20 Platelet count; LUSC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.63 9.69 0.47 9.58e-20 Cognitive test performance; LUSC cis rs59918340 0.523 rs4961255 chr8:142208248 T/C cg18755752 chr8:142205143 DENND3 -0.49 -7.44 -0.38 8.84e-13 Immature fraction of reticulocytes; LUSC cis rs7123876 0.587 rs11601122 chr11:72362718 A/G cg04827223 chr11:72435913 ARAP1 -0.63 -7.18 -0.37 4.57e-12 Body mass index; LUSC cis rs11077815 0.815 rs394873 chr17:74413449 A/G cg06840243 chr17:74442338 UBE2O 0.32 5.76 0.3 1.87e-8 Lymphocyte counts; LUSC cis rs12050794 0.636 rs4506844 chr15:72509138 C/T cg16672083 chr15:72433130 SENP8 0.47 7.9 0.4 4.11e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg00074818 chr8:8560427 CLDN23 0.59 9.8 0.47 4.21e-20 Obesity-related traits; LUSC cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg21535247 chr6:8435926 SLC35B3 0.58 8.97 0.44 2.18e-17 Motion sickness; LUSC cis rs9300255 0.602 rs1790131 chr12:123701010 G/T cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg12463550 chr7:65579703 CRCP -0.55 -8.36 -0.42 1.77e-15 Aortic root size; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg02092906 chr6:83903419 PGM3;RWDD2A -0.37 -5.98 -0.31 5.77e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs8017423 0.935 rs4643251 chr14:90669256 C/T cg04374321 chr14:90722782 PSMC1 -0.67 -9.95 -0.48 1.32e-20 Mortality in heart failure; LUSC cis rs9914988 0.943 rs9890377 chr17:27111111 A/G cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg08888203 chr3:10149979 C3orf24 0.61 8.22 0.41 4.4e-15 Alzheimer's disease; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg03909902 chr12:108154529 PRDM4 -0.35 -6.43 -0.33 4.46e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7539542 0.556 rs6662413 chr1:202888496 C/T cg19681188 chr1:202830198 LOC148709 -0.39 -5.75 -0.3 2.06e-8 Mean platelet volume; LUSC cis rs9517320 0.935 rs1886089 chr13:99124356 C/T cg07423050 chr13:99094983 FARP1 0.33 6.23 0.32 1.41e-9 Longevity; LUSC cis rs7771547 0.519 rs6917489 chr6:36368169 C/T cg07856975 chr6:36356162 ETV7 0.41 6.03 0.31 4.4e-9 Platelet distribution width; LUSC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC trans rs629535 0.814 rs62513373 chr8:70080753 C/T cg21567404 chr3:27674614 NA -0.97 -15.65 -0.65 8.2e-42 Dupuytren's disease; LUSC cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg13256891 chr4:100009986 ADH5 0.45 6.24 0.32 1.3e-9 Alcohol dependence; LUSC cis rs7937682 0.889 rs11213971 chr11:111529829 A/G cg22437258 chr11:111473054 SIK2 0.51 6.93 0.35 2.15e-11 Primary sclerosing cholangitis; LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.45 0.38 8.15e-13 Prudent dietary pattern; LUSC cis rs208520 0.690 rs4710564 chr6:66823478 A/G cg07460842 chr6:66804631 NA 1.01 15.34 0.64 1.37e-40 Exhaled nitric oxide output; LUSC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.29 -0.41 2.74e-15 Cystic fibrosis severity; LUSC cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg08213375 chr14:104286397 PPP1R13B 0.43 8.25 0.41 3.62e-15 Schizophrenia; LUSC cis rs3106136 0.967 rs8026 chr4:95212185 A/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.24 -0.32 1.33e-9 Capecitabine sensitivity; LUSC cis rs7572644 0.699 rs4233719 chr2:28079344 C/A cg27432699 chr2:27873401 GPN1 0.52 7.02 0.36 1.23e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs800082 0.768 rs2222702 chr3:144258814 T/A cg24215973 chr2:240111563 HDAC4 0.41 6.11 0.32 2.74e-9 Smoking behavior; LUSC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg27165867 chr14:105738592 BRF1 -0.51 -7.21 -0.37 3.83e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs7586879 0.828 rs13428789 chr2:25087643 C/T cg01884057 chr2:25150051 NA 0.39 8.22 0.41 4.45e-15 Body mass index; LUSC cis rs9549367 1.000 rs9549367 chr13:113911532 C/G cg00898013 chr13:113819073 PROZ -0.49 -7.08 -0.36 8.8e-12 Platelet distribution width; LUSC cis rs2130392 0.503 rs2871418 chr4:185654723 A/G cg21366198 chr4:185655624 MLF1IP 0.39 5.75 0.3 2e-8 Kawasaki disease; LUSC trans rs8073060 0.586 rs226084 chr17:34019582 T/A cg19694781 chr19:47549865 TMEM160 -1.13 -17.99 -0.7 4.71e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg20701182 chr2:24300061 SF3B14 0.87 11.4 0.53 1.19e-25 Lymphocyte counts; LUSC cis rs9341808 0.718 rs2322636 chr6:80897436 C/T cg08355045 chr6:80787529 NA 0.59 10.22 0.49 1.58e-21 Sitting height ratio; LUSC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg03804128 chr16:635623 NA 0.3 5.83 0.3 1.28e-8 Height; LUSC trans rs1814175 0.765 rs1722003 chr11:49895896 G/A cg03929089 chr4:120376271 NA -1.05 -20.51 -0.75 4.34e-61 Height; LUSC cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg22681709 chr2:178499509 PDE11A -0.51 -9.08 -0.44 9.97e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg03676636 chr4:99064102 C4orf37 0.36 7.99 0.4 2.15e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11191270 0.590 rs12569901 chr10:104025410 C/G cg15320455 chr10:103880129 LDB1 0.56 5.73 0.3 2.21e-8 Intelligence (multi-trait analysis); LUSC trans rs9929218 0.529 rs8059194 chr16:68749663 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.05 23.89 0.79 3e-74 Colorectal cancer; LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg14092988 chr3:52407081 DNAH1 0.31 6.17 0.32 2e-9 Bipolar disorder; LUSC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg00701064 chr4:6280414 WFS1 0.61 14.8 0.63 1.85e-38 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs9929218 0.906 rs4783565 chr16:68750190 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -13.04 -0.58 1.04e-31 Colorectal cancer; LUSC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg10729496 chr3:10149963 C3orf24 0.57 7.55 0.38 4.11e-13 Alzheimer's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20861091 chr8:144881744 SCRIB 0.55 6.82 0.35 4.27e-11 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3820928 0.967 rs2396435 chr2:227778397 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.97 -0.4 2.57e-14 Pulmonary function; LUSC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs12410462 0.681 rs6682883 chr1:227635598 G/A cg10327440 chr1:227177885 CDC42BPA -0.67 -5.74 -0.3 2.17e-8 Major depressive disorder; LUSC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg04362960 chr10:104952993 NT5C2 0.58 9.16 0.45 5.32e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.22e-10 Aortic root size; LUSC cis rs7719624 0.846 rs2237066 chr5:135367603 C/T cg12897067 chr5:135418308 NA -0.45 -6.53 -0.34 2.4e-10 Response to cytidine analogues (gemcitabine); LUSC cis rs765787 0.530 rs12905246 chr15:45500841 C/T cg25801113 chr15:45476975 SHF -0.33 -6.43 -0.33 4.29e-10 Uric acid levels; LUSC cis rs4478858 0.684 rs2062951 chr1:31762981 T/C cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs6545883 0.860 rs777589 chr2:61425621 T/C cg15711740 chr2:61764176 XPO1 -0.43 -6.65 -0.34 1.21e-10 Tuberculosis; LUSC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg06028605 chr16:24865363 SLC5A11 0.64 9.68 0.47 1.08e-19 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.806 rs7626557 chr3:134318213 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.39 -0.56 2.93e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.88 -14.74 -0.63 3.14e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg26597838 chr10:835615 NA 1.07 13.74 0.6 2.38e-34 Eosinophil percentage of granulocytes; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg01802117 chr1:53393560 SCP2 -0.39 -6.44 -0.33 4.16e-10 Monocyte count; LUSC cis rs8180040 1.000 rs807810 chr3:47403892 G/A cg27129171 chr3:47204927 SETD2 -0.71 -12.2 -0.56 1.43e-28 Colorectal cancer; LUSC cis rs6541297 1.000 rs11122405 chr1:230282997 C/A cg20703242 chr1:230279135 GALNT2 0.57 8.71 0.43 1.39e-16 Coronary artery disease; LUSC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg13206674 chr6:150067644 NUP43 0.58 9.19 0.45 4.25e-18 Lung cancer; LUSC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg17366294 chr4:99064904 C4orf37 0.6 10.69 0.5 3.82e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1030268 0.505 rs77112963 chr7:133259399 G/A cg10665199 chr7:133106180 EXOC4 0.64 7.15 0.36 5.68e-12 Intelligence (multi-trait analysis); LUSC cis rs12134245 0.874 rs34842487 chr1:92021611 C/T cg02896835 chr1:92012615 NA -0.53 -8.93 -0.44 2.88e-17 Breast cancer; LUSC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg04539111 chr16:67997858 SLC12A4 -0.46 -6.24 -0.32 1.35e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7829975 0.660 rs10093926 chr8:8549020 A/C cg08975724 chr8:8085496 FLJ10661 -0.41 -5.97 -0.31 6.07e-9 Mood instability; LUSC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg03806693 chr22:41940476 POLR3H 0.98 13.57 0.6 1.03e-33 Vitiligo; LUSC cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg26408565 chr15:76604113 ETFA -0.42 -6.51 -0.34 2.82e-10 Blood metabolite levels; LUSC cis rs17270561 0.562 rs74293932 chr6:26014811 C/A cg17691542 chr6:26056736 HIST1H1C 1.0 12.67 0.57 2.59e-30 Iron status biomarkers; LUSC cis rs1371867 0.846 rs1788191 chr8:101260844 C/T cg06636551 chr8:101224915 SPAG1 0.43 7.88 0.4 4.8e-14 Atrioventricular conduction; LUSC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg25251562 chr2:3704773 ALLC -0.48 -7.39 -0.38 1.15e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg04362960 chr10:104952993 NT5C2 0.59 9.51 0.46 3.97e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg01884057 chr2:25150051 NA 0.42 9.13 0.45 6.57e-18 Body mass index; LUSC cis rs13006833 1.000 rs13006833 chr2:191205499 G/C cg21644426 chr2:191273491 MFSD6 0.45 6.4 0.33 5.26e-10 Urinary metabolites; LUSC cis rs529866 0.555 rs367569 chr16:11365500 C/T cg00044050 chr16:11439710 C16orf75 0.56 7.83 0.39 6.35e-14 Crohn's disease;Inflammatory bowel disease; LUSC cis rs709400 0.663 rs62007684 chr14:103894223 T/C cg24130564 chr14:104152367 KLC1 -0.46 -6.38 -0.33 6.01e-10 Body mass index; LUSC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.52e-24 Aortic root size; LUSC cis rs834603 0.575 rs1612394 chr7:47467609 G/A cg09696706 chr7:47479511 TNS3 0.32 5.75 0.3 2.01e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23319046 chr18:3247432 MYL12A -0.42 -6.26 -0.32 1.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg09085632 chr11:111637200 PPP2R1B -1.09 -17.54 -0.69 2.71e-49 Primary sclerosing cholangitis; LUSC cis rs11098499 0.954 rs10017543 chr4:120321420 G/A cg24375607 chr4:120327624 NA 0.78 11.51 0.53 4.85e-26 Corneal astigmatism; LUSC cis rs13064411 0.696 rs6769516 chr3:113219905 T/C cg18753928 chr3:113234510 CCDC52 -0.51 -7.96 -0.4 2.8e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC trans rs208520 0.661 rs7766144 chr6:66827795 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -17.52 -0.69 3.22e-49 Exhaled nitric oxide output; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05431684 chr11:130781542 SNX19 0.42 6.15 0.32 2.2e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg10523679 chr1:76189770 ACADM 0.91 16.24 0.66 4e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg02269571 chr22:50332266 NA 0.46 6.34 0.33 7.36e-10 Schizophrenia; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg21548813 chr6:291882 DUSP22 0.73 12.23 0.56 1.11e-28 Menopause (age at onset); LUSC cis rs6977660 0.943 rs9639334 chr7:19838810 G/A cg07541023 chr7:19748670 TWISTNB 0.54 6.16 0.32 2.06e-9 Thyroid stimulating hormone; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg12432903 chr7:1882776 MAD1L1 -0.38 -5.97 -0.31 5.92e-9 Bipolar disorder and schizophrenia; LUSC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg13390004 chr1:15929781 NA 0.42 7.13 0.36 6.1e-12 Systolic blood pressure; LUSC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg20607287 chr7:12443886 VWDE -0.65 -6.59 -0.34 1.74e-10 Coronary artery disease; LUSC cis rs796364 0.616 rs769956 chr2:200693720 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.5 -5.81 -0.3 1.46e-8 Schizophrenia; LUSC cis rs10911251 0.528 rs10911266 chr1:183115097 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.66 0.5 5e-23 Colorectal cancer; LUSC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.02 -0.31 4.72e-9 Crohn's disease; LUSC cis rs3924048 0.574 rs11121928 chr1:12615888 C/G cg00291366 chr1:12616550 NA 0.37 9.61 0.47 1.82e-19 Optic cup area; LUSC cis rs7954584 0.583 rs6486782 chr12:122359172 T/C cg21171335 chr12:122356390 WDR66 0.55 7.8 0.39 7.97e-14 Mean corpuscular volume; LUSC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.35 -0.8 4.97e-76 Height; LUSC cis rs977987 0.806 rs12930768 chr16:75464500 T/C cg03315344 chr16:75512273 CHST6 0.5 9.55 0.46 2.98e-19 Dupuytren's disease; LUSC cis rs546131 0.928 rs572690 chr11:34833614 A/G cg11058730 chr11:34937778 PDHX;APIP 0.46 6.35 0.33 7.23e-10 Lung disease severity in cystic fibrosis; LUSC trans rs8002861 0.713 rs7339417 chr13:44413496 A/T cg12856521 chr11:46389249 DGKZ 0.43 6.34 0.33 7.27e-10 Leprosy; LUSC cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg11584989 chr19:19387371 SF4 0.57 6.82 0.35 4.18e-11 Bipolar disorder; LUSC cis rs9650315 0.866 rs7815909 chr8:57200362 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.28 0.37 2.42e-12 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01122304 chr4:2845576 ADD1 -0.39 -6.21 -0.32 1.58e-9 Electrocardiographic conduction measures; LUSC trans rs10435719 0.899 rs11250177 chr8:11799099 G/A cg08975724 chr8:8085496 FLJ10661 0.46 6.63 0.34 1.36e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9640161 0.659 rs7781827 chr7:150008858 T/C cg17279839 chr7:150038598 RARRES2 0.43 6.8 0.35 4.79e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2303282 1.000 rs2303282 chr16:56531185 C/G cg00500540 chr16:56394104 NA -0.44 -7.05 -0.36 1.04e-11 Breast cancer; LUSC cis rs11098499 0.954 rs17005535 chr4:120411562 C/T cg24375607 chr4:120327624 NA 0.79 11.94 0.55 1.32e-27 Corneal astigmatism; LUSC cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg21535247 chr6:8435926 SLC35B3 0.62 9.72 0.47 7.79e-20 Motion sickness; LUSC cis rs9910055 0.659 rs227578 chr17:42210189 C/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.48 -8.75 -0.43 1.11e-16 Total body bone mineral density; LUSC cis rs16854884 0.683 rs2053211 chr3:143774592 C/T cg06585982 chr3:143692056 C3orf58 -0.4 -6.13 -0.32 2.52e-9 Economic and political preferences (feminism/equality); LUSC cis rs7681440 0.647 rs1372508 chr4:90819786 C/G cg20003494 chr4:90757398 SNCA 0.35 5.81 0.3 1.48e-8 Dementia with Lewy bodies; LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg07703079 chr11:430292 ANO9 0.65 6.75 0.35 6.67e-11 Body mass index; LUSC cis rs2354432 0.714 rs7531962 chr1:146746023 G/A cg25205988 chr1:146714368 CHD1L -1.08 -12.67 -0.57 2.61e-30 Mitochondrial DNA levels; LUSC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg18225595 chr11:63971243 STIP1 0.61 10.33 0.49 6.88e-22 Platelet count; LUSC cis rs2070488 0.662 rs7372545 chr3:38507570 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 10.0 0.48 9.28e-21 Electrocardiographic conduction measures; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg27535305 chr1:53392650 SCP2 0.36 6.78 0.35 5.43e-11 Monocyte count; LUSC cis rs7909074 1.000 rs10751361 chr10:45398186 C/A cg04218760 chr10:45406644 TMEM72 -0.3 -7.14 -0.36 5.73e-12 Mean corpuscular volume; LUSC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg22963979 chr7:1858916 MAD1L1 -0.55 -8.39 -0.42 1.42e-15 Bipolar disorder and schizophrenia; LUSC cis rs295140 0.526 rs295114 chr2:201195602 C/T cg23649088 chr2:200775458 C2orf69 0.4 6.03 0.31 4.4e-9 QT interval; LUSC cis rs10791097 0.694 rs4370948 chr11:130755700 A/C cg12179176 chr11:130786555 SNX19 0.85 14.78 0.63 2.26e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs10392 0.543 rs4812332 chr20:37534665 C/T cg27552599 chr20:37590471 DHX35 0.42 6.57 0.34 1.96e-10 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs79976124 0.837 rs11751994 chr6:66644028 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 8.81 0.43 7.1e-17 Type 2 diabetes; LUSC cis rs9311676 0.632 rs4228 chr3:58413669 G/T cg13750441 chr3:58318267 PXK 0.35 6.86 0.35 3.41e-11 Systemic lupus erythematosus; LUSC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg03929089 chr4:120376271 NA -1.04 -20.09 -0.74 2.02e-59 Height; LUSC cis rs709400 0.604 rs7158144 chr14:103887615 A/G cg24130564 chr14:104152367 KLC1 -0.45 -6.2 -0.32 1.62e-9 Body mass index; LUSC cis rs10779751 1.000 rs11121703 chr1:11293792 G/T cg08854313 chr1:11322531 MTOR -0.88 -15.01 -0.63 2.68e-39 Body mass index; LUSC cis rs941408 0.515 rs2110118 chr19:2775144 T/C cg17333051 chr19:2783644 SGTA 0.49 7.38 0.37 1.26e-12 Total cholesterol levels; LUSC cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.0 0.4 2.03e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs3862030 0.694 rs41306870 chr10:104229785 C/T cg05855489 chr10:104503620 C10orf26 0.49 7.36 0.37 1.48e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs1459104 0.866 rs66989058 chr11:54823043 C/A cg03929089 chr4:120376271 NA 0.7 6.12 0.32 2.63e-9 Body mass index; LUSC cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7428496 0.528 rs2227931 chr3:142222284 A/G cg16271453 chr3:142027066 XRN1 -0.51 -8.95 -0.44 2.6e-17 Mean corpuscular hemoglobin; LUSC cis rs1185460 1.000 rs1614264 chr11:118942638 A/C cg23280166 chr11:118938394 VPS11 0.44 6.76 0.35 6.13e-11 Coronary artery disease; LUSC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg22442454 chr1:209979470 IRF6 0.43 5.81 0.3 1.46e-8 Cleft lip with or without cleft palate; LUSC cis rs6489882 0.867 rs6489866 chr12:113363408 A/G cg20102336 chr12:113376681 OAS3 -0.42 -5.93 -0.31 7.36e-9 Chronic lymphocytic leukemia; LUSC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg09904177 chr6:26538194 HMGN4 0.42 6.15 0.32 2.16e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg20135002 chr11:47629003 NA -0.52 -8.08 -0.4 1.17e-14 Subjective well-being; LUSC cis rs239198 0.602 rs9390698 chr6:101296389 G/A cg09795085 chr6:101329169 ASCC3 0.45 6.36 0.33 6.54e-10 Menarche (age at onset); LUSC cis rs1322512 1.000 rs2800633 chr6:153010308 T/G cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs7759001 0.817 rs1883405 chr6:27350424 T/A cg18711553 chr6:27366782 ZNF391 0.4 5.9 0.31 8.74e-9 Glomerular filtration rate (creatinine); LUSC cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs16912285 0.688 rs1899540 chr11:24339992 A/G ch.11.24196551F chr11:24239977 NA 0.81 7.79 0.39 8.47e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2652834 0.851 rs4775628 chr15:63426463 A/C cg05507819 chr15:63340323 TPM1 0.45 5.82 0.3 1.37e-8 HDL cholesterol; LUSC trans rs17685 0.753 rs6951943 chr7:75772452 A/G cg19862616 chr7:65841803 NCRNA00174 1.14 19.67 0.73 9.55e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs11971779 0.616 rs6967932 chr7:139022381 C/T cg07862535 chr7:139043722 LUC7L2 0.54 6.74 0.35 6.84e-11 Diisocyanate-induced asthma; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg23633666 chr10:44101845 ZNF485 0.47 6.12 0.32 2.65e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7647973 0.626 rs7637711 chr3:49829653 A/G cg03060546 chr3:49711283 APEH -0.63 -7.6 -0.38 3.08e-13 Menarche (age at onset); LUSC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg03676636 chr4:99064102 C4orf37 0.36 8.07 0.4 1.3e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs524023 0.874 rs492175 chr11:64433078 A/G cg19131476 chr11:64387923 NRXN2 0.37 10.07 0.48 5.2e-21 Urate levels in obese individuals; LUSC cis rs10207060 0.500 rs28640956 chr2:240714001 G/C cg20333904 chr2:240724165 NA -0.35 -6.15 -0.32 2.26e-9 Obesity-related traits; LUSC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg07701084 chr6:150067640 NUP43 -0.59 -9.26 -0.45 2.63e-18 Lung cancer; LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg05368731 chr17:41323189 NBR1 0.93 15.69 0.65 5.75e-42 Menopause (age at onset); LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg22903657 chr4:1355424 KIAA1530 -0.36 -6.09 -0.32 3.11e-9 Obesity-related traits; LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.81 0.3 1.48e-8 Menopause (age at onset); LUSC cis rs2290416 0.892 rs3793369 chr8:144664335 G/A cg08017634 chr8:144659831 NAPRT1 0.69 6.11 0.32 2.72e-9 Attention deficit hyperactivity disorder; LUSC trans rs561341 0.883 rs7219239 chr17:30212016 A/G cg20587970 chr11:113659929 NA 1.14 13.52 0.59 1.65e-33 Hip circumference adjusted for BMI; LUSC cis rs34638657 0.872 rs6420436 chr16:82186719 C/G cg09439754 chr16:82129088 HSD17B2 -0.39 -6.06 -0.31 3.66e-9 Lung adenocarcinoma; LUSC cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg20684491 chr1:25596433 NA -0.39 -6.33 -0.33 7.97e-10 Plateletcrit;Mean corpuscular volume; LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs9811920 0.809 rs4928151 chr3:99767553 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.34 5.8 0.3 1.52e-8 Axial length; LUSC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg17211192 chr8:82754475 SNX16 -0.81 -11.06 -0.52 1.89e-24 Diastolic blood pressure; LUSC cis rs11190604 1.000 rs2489043 chr10:102334327 T/C cg16342193 chr10:102329863 NA -0.36 -6.77 -0.35 5.77e-11 Palmitoleic acid (16:1n-7) levels; LUSC trans rs9503598 0.636 rs6596974 chr6:3465833 C/T cg05722439 chr19:14072965 RFX1 -0.31 -6.02 -0.31 4.72e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs4919687 0.550 rs10437480 chr10:104453024 C/G cg04362960 chr10:104952993 NT5C2 0.47 6.9 0.35 2.62e-11 Colorectal cancer; LUSC cis rs34638657 0.827 rs6564996 chr16:82207542 T/C cg09439754 chr16:82129088 HSD17B2 -0.37 -5.68 -0.3 2.98e-8 Lung adenocarcinoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07284286 chr16:58662935 CNOT1 0.48 7.48 0.38 6.45e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1559088 0.744 rs12462426 chr19:33536683 A/C cg27124370 chr19:33622961 WDR88 0.47 6.08 0.32 3.33e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12973672 0.855 rs7256866 chr19:35771257 A/G cg12095397 chr19:35769544 USF2 0.44 6.77 0.35 5.67e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs59104589 0.617 rs62193220 chr2:242353493 G/A cg14842376 chr2:242211374 HDLBP 0.53 6.22 0.32 1.53e-9 Fibrinogen levels; LUSC trans rs7681440 0.904 rs35424815 chr4:90767877 C/T cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg21138405 chr5:131827807 IRF1 0.48 9.5 0.46 4.32e-19 Breast cancer;Mosquito bite size; LUSC cis rs9309473 0.948 rs10173534 chr2:73813432 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.62 -0.34 1.4e-10 Metabolite levels; LUSC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg09877947 chr5:131593287 PDLIM4 -0.45 -6.87 -0.35 3.19e-11 Breast cancer; LUSC cis rs56283067 0.887 rs62437968 chr6:44729495 G/A cg20913747 chr6:44695427 NA -0.5 -8.25 -0.41 3.77e-15 Total body bone mineral density; LUSC trans rs6590322 0.513 rs4937325 chr11:128222116 T/C cg19073447 chr10:134024191 STK32C -0.37 -6.21 -0.32 1.55e-9 Hippocampal atrophy; LUSC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.6 -8.18 -0.41 6.14e-15 Systemic lupus erythematosus; LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg04518342 chr5:131593106 PDLIM4 0.43 7.64 0.39 2.35e-13 Breast cancer; LUSC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.34 0.33 7.28e-10 Hip circumference adjusted for BMI; LUSC cis rs3749237 1.000 rs11920900 chr3:49823024 G/C cg03060546 chr3:49711283 APEH 0.61 8.41 0.42 1.24e-15 Resting heart rate; LUSC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg21724239 chr8:58056113 NA 0.56 6.71 0.34 8.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg26314531 chr2:26401878 FAM59B -0.68 -9.13 -0.45 6.62e-18 Gut microbiome composition (summer); LUSC trans rs17278117 0.558 rs7675612 chr4:182596023 A/G cg11957848 chr6:169575326 NA 0.64 6.08 0.32 3.31e-9 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs1372520 0.935 rs2245801 chr4:90757840 T/C cg15133208 chr4:90757351 SNCA -0.5 -7.31 -0.37 2.03e-12 Neuroticism; LUSC cis rs11610422 0.954 rs12830705 chr12:31415204 C/T cg14306366 chr12:31406441 NA -0.47 -5.77 -0.3 1.82e-8 Coronary artery disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg21966860 chr8:145538097 HSF1 -0.37 -6.1 -0.32 2.86e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9549367 0.774 rs2287246 chr13:113889127 A/G cg18105134 chr13:113819100 PROZ -0.67 -9.51 -0.46 3.79e-19 Platelet distribution width; LUSC cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC cis rs710216 0.843 rs844501 chr1:43440783 G/A cg22176566 chr1:43424700 SLC2A1 0.47 5.71 0.3 2.47e-8 Red cell distribution width; LUSC cis rs929354 0.772 rs6954050 chr7:156978554 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs731174 0.797 rs670692 chr1:38148124 G/A cg14170840 chr1:38155120 C1orf109 -0.38 -5.97 -0.31 6.21e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg03354898 chr7:1950403 MAD1L1 -0.33 -6.37 -0.33 6.38e-10 Bipolar disorder and schizophrenia; LUSC trans rs9929218 1.000 rs2113199 chr16:68814502 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.78 -0.54 5.17e-27 Colorectal cancer; LUSC cis rs11055008 0.935 rs10845601 chr12:12820134 A/G cg04607235 chr12:12878440 APOLD1 0.55 8.25 0.41 3.72e-15 Pulse pressure; LUSC cis rs977987 0.931 rs7195161 chr16:75495572 T/C cg03315344 chr16:75512273 CHST6 0.52 9.8 0.47 4.44e-20 Dupuytren's disease; LUSC cis rs12681288 0.676 rs2701901 chr8:1017816 G/C cg04851639 chr8:1020857 NA -0.39 -7.98 -0.4 2.3e-14 Schizophrenia; LUSC trans rs2836974 0.613 rs2245455 chr21:40548087 A/T cg24896697 chr17:25660093 NA -0.46 -6.8 -0.35 4.96e-11 Cognitive function; LUSC cis rs6519955 0.765 rs7292527 chr22:46423125 G/T cg09693106 chr22:46449821 C22orf26;LOC150381 -0.38 -5.87 -0.31 1.03e-8 Dupuytren's disease; LUSC cis rs12971120 0.891 rs11151961 chr18:72177340 C/T cg26446133 chr18:72167187 CNDP2 -0.76 -9.18 -0.45 4.79e-18 Refractive error; LUSC cis rs4631830 0.683 rs11004409 chr10:51498019 G/C cg16070123 chr10:51489643 NA 0.57 9.38 0.46 1.07e-18 Prostate-specific antigen levels; LUSC cis rs1153858 1.000 rs1346266 chr15:45694516 G/T cg26924012 chr15:45694286 SPATA5L1 1.11 19.72 0.73 5.85e-58 Homoarginine levels; LUSC cis rs7940866 0.801 rs10894300 chr11:130845943 A/G cg12179176 chr11:130786555 SNX19 0.57 8.65 0.43 2.2e-16 Schizophrenia; LUSC cis rs929354 0.742 rs11980541 chr7:156988776 G/C cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9811920 0.516 rs793485 chr3:99492383 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.3 -5.7 -0.3 2.58e-8 Axial length; LUSC cis rs793571 0.523 rs7163162 chr15:58983588 T/A cg05156742 chr15:59063176 FAM63B 0.52 7.56 0.38 3.85e-13 Schizophrenia; LUSC cis rs10843647 1.000 rs1586281 chr12:30325631 G/C cg12718339 chr12:29936407 TMTC1 -0.35 -5.89 -0.31 9.61e-9 Glucose homeostasis traits; LUSC cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg27446573 chr6:127587934 RNF146 0.91 15.04 0.64 2.2e-39 Breast cancer; LUSC cis rs35306767 0.668 rs72760914 chr10:1070952 A/G cg20503657 chr10:835505 NA 0.57 7.44 0.38 8.41e-13 Eosinophil percentage of granulocytes; LUSC cis rs2652834 0.519 rs4075584 chr15:63340292 C/T cg00520135 chr15:63333846 TPM1 -0.35 -5.75 -0.3 2e-8 HDL cholesterol; LUSC cis rs9677476 0.863 rs16827863 chr2:232077670 C/T cg07929768 chr2:232055508 NA -0.34 -6.63 -0.34 1.36e-10 Food antigen IgG levels; LUSC cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg15073853 chr19:18549131 ISYNA1 -0.31 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs4808199 0.895 rs6511036 chr19:19582651 A/G cg03709012 chr19:19516395 GATAD2A 1.1 14.57 0.62 1.44e-37 Nonalcoholic fatty liver disease; LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.62 0.38 2.68e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg07701084 chr6:150067640 NUP43 0.58 8.92 0.44 3.05e-17 Lung cancer; LUSC cis rs1865760 0.929 rs9358896 chr6:25943197 C/A cg17691542 chr6:26056736 HIST1H1C 0.49 7.22 0.37 3.48e-12 Height; LUSC cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.19 -0.41 5.42e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs6489785 0.643 rs2015462 chr12:121238204 G/C cg02403541 chr12:121454288 C12orf43 0.39 5.86 0.31 1.09e-8 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg09455208 chr3:40491958 NA 0.56 10.19 0.49 2.09e-21 Renal cell carcinoma; LUSC cis rs1401999 0.690 rs3805112 chr3:183645662 C/T cg01324343 chr3:183735012 ABCC5 0.66 17.08 0.68 1.81e-47 Anterior chamber depth; LUSC cis rs8017423 0.647 rs12883357 chr14:90815032 A/G cg14092571 chr14:90743983 NA 0.33 5.74 0.3 2.14e-8 Mortality in heart failure; LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg02951883 chr7:2050386 MAD1L1 -0.37 -6.37 -0.33 6.14e-10 Bipolar disorder and schizophrenia; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg24953233 chr5:892707 TRIP13;BRD9 0.38 5.98 0.31 5.85e-9 Metabolite levels (Pyroglutamine); LUSC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.45 0.33 3.85e-10 Lung cancer; LUSC cis rs8060686 0.623 rs74024145 chr16:68153382 G/C cg05110241 chr16:68378359 PRMT7 -0.45 -5.96 -0.31 6.5e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg12311346 chr5:56204834 C5orf35 -0.62 -9.05 -0.44 1.21e-17 Coronary artery disease; LUSC cis rs7267979 1.000 rs6050602 chr20:25401203 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3820928 1.000 rs4673173 chr2:227769493 A/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.94 -0.4 3.07e-14 Pulmonary function; LUSC trans rs804280 0.509 rs9886639 chr8:11784529 G/T cg08975724 chr8:8085496 FLJ10661 0.49 7.19 0.37 4.18e-12 Myopia (pathological); LUSC cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg27446573 chr6:127587934 RNF146 0.92 15.23 0.64 3.94e-40 Breast cancer; LUSC cis rs1994135 0.669 rs10844628 chr12:33697065 T/C cg06521331 chr12:34319734 NA -0.39 -5.74 -0.3 2.14e-8 Resting heart rate; LUSC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg06634786 chr22:41940651 POLR3H -0.48 -5.74 -0.3 2.11e-8 Vitiligo; LUSC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg05535760 chr7:792225 HEATR2 0.78 9.16 0.45 5.34e-18 Cerebrospinal P-tau181p levels; LUSC cis rs11039100 0.607 rs61875872 chr11:5780615 T/A cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg18131467 chr2:239335373 ASB1 1.03 25.05 0.81 1.11e-78 Multiple system atrophy; LUSC cis rs66887589 0.777 rs2017058 chr4:120257739 T/C cg13609457 chr4:120235615 NA 0.37 5.84 0.3 1.24e-8 Diastolic blood pressure; LUSC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg18479299 chr3:125709523 NA -0.5 -6.02 -0.31 4.59e-9 Blood pressure (smoking interaction); LUSC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg03233332 chr7:66118400 NA 0.4 5.92 0.31 8.07e-9 Aortic root size; LUSC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg12365402 chr11:9010492 NRIP3 -0.41 -7.44 -0.38 8.57e-13 Hemoglobin concentration; LUSC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg15704280 chr7:45808275 SEPT13 -1.04 -18.03 -0.7 3.22e-51 Coronary artery disease; LUSC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg20203395 chr5:56204925 C5orf35 -0.72 -9.84 -0.47 3.21e-20 Initial pursuit acceleration; LUSC cis rs854765 0.624 rs9902941 chr17:17733760 C/T cg16928487 chr17:17741425 SREBF1 0.46 9.12 0.45 7.18e-18 Total body bone mineral density; LUSC cis rs295140 0.507 rs13019821 chr2:201106815 C/G cg23649088 chr2:200775458 C2orf69 -0.47 -7.1 -0.36 7.44e-12 QT interval; LUSC cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg23711669 chr6:146136114 FBXO30 0.86 15.87 0.66 1.21e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs4901869 0.966 rs60800733 chr14:59337778 A/G cg02291164 chr14:59296302 NA 0.57 10.94 0.51 4.96e-24 Panic disorder; LUSC cis rs10193935 0.792 rs7559001 chr2:42474301 C/T cg27598129 chr2:42591480 NA -0.6 -8.04 -0.4 1.63e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs8072100 0.744 rs34537623 chr17:45530203 A/G cg03886242 chr7:26192032 NFE2L3 -0.37 -6.14 -0.32 2.4e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.34 0.67 1.65e-44 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01959412 chr4:4861398 MSX1 -0.49 -7.13 -0.36 6.29e-12 Bipolar disorder and schizophrenia; LUSC cis rs2637266 0.967 rs2395407 chr10:78380573 T/A cg18941641 chr10:78392320 NA 0.4 7.31 0.37 1.97e-12 Pulmonary function; LUSC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -10.12 -0.48 3.61e-21 Developmental language disorder (linguistic errors); LUSC cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg04733989 chr22:42467013 NAGA 0.49 7.89 0.4 4.26e-14 Schizophrenia; LUSC trans rs11039798 0.541 rs11040166 chr11:48965449 T/C cg15704280 chr7:45808275 SEPT13 0.81 7.04 0.36 1.11e-11 Axial length; LUSC cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg02782426 chr3:40428986 ENTPD3 0.32 6.16 0.32 2.12e-9 Renal cell carcinoma; LUSC cis rs72960926 0.744 rs11754787 chr6:74915037 A/T cg03266952 chr6:74778945 NA -0.79 -6.43 -0.33 4.37e-10 Metabolite levels (MHPG); LUSC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs981844 0.775 rs62323979 chr4:154752935 T/C cg14289246 chr4:154710475 SFRP2 0.48 6.43 0.33 4.46e-10 Response to statins (LDL cholesterol change); LUSC cis rs3008870 1.000 rs2755245 chr1:67487964 C/G cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.12 0.64 1.05e-39 Lymphocyte percentage of white cells; LUSC cis rs6489785 0.522 rs1718188 chr12:121343893 T/A cg02419362 chr12:121203948 SPPL3 -0.39 -6.78 -0.35 5.33e-11 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs477692 1.000 rs503660 chr10:131418999 A/G cg05714579 chr10:131428358 MGMT 0.49 7.44 0.38 8.62e-13 Response to temozolomide; LUSC cis rs7432375 0.610 rs56163507 chr3:136516056 C/T cg15507776 chr3:136538369 TMEM22 0.44 7.34 0.37 1.68e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs62458065 0.713 rs28421905 chr7:32489501 G/A cg00845942 chr12:64062724 DPY19L2 -0.55 -6.67 -0.34 1.08e-10 Metabolite levels (HVA/MHPG ratio); LUSC cis rs4820539 0.708 rs5751591 chr22:23489042 G/A cg21100191 chr22:23484243 RTDR1 0.68 10.05 0.48 6.23e-21 Bone mineral density; LUSC cis rs8060686 0.545 rs12596883 chr16:68172416 A/T cg09835421 chr16:68378352 PRMT7 -0.59 -6.21 -0.32 1.55e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7246967 0.673 rs12979264 chr19:22865134 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.57e-11 Bronchopulmonary dysplasia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05704155 chr1:10459140 PGD -0.38 -6.21 -0.32 1.59e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9948 0.521 rs62156207 chr2:97359236 C/A cg01990225 chr2:97406019 LMAN2L -1.07 -7.86 -0.4 5.2e-14 Erectile dysfunction and prostate cancer treatment; LUSC cis rs4356932 1.000 rs4580676 chr4:76953295 G/A cg00809888 chr4:76862425 NAAA 0.34 5.71 0.3 2.44e-8 Blood protein levels; LUSC cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.48 6.78 0.35 5.57e-11 Chronic sinus infection; LUSC cis rs4363385 0.747 rs2339495 chr1:152975116 A/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg11062466 chr8:58055876 NA 0.51 6.48 0.33 3.36e-10 Developmental language disorder (linguistic errors); LUSC cis rs826838 0.616 rs10880751 chr12:38627485 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.82 0.35 4.4e-11 Heart rate; LUSC cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg12564285 chr5:131593104 PDLIM4 -0.38 -7.02 -0.36 1.27e-11 Blood metabolite levels; LUSC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg23283495 chr1:209979779 IRF6 0.64 7.9 0.4 4.2e-14 Cleft lip with or without cleft palate; LUSC cis rs2115630 0.764 rs11073716 chr15:85335774 C/T cg17173187 chr15:85201210 NMB -0.29 -5.81 -0.3 1.44e-8 P wave terminal force; LUSC cis rs4343996 0.870 rs4443553 chr7:3378635 T/C cg21248987 chr7:3385318 SDK1 -0.39 -6.86 -0.35 3.3e-11 Motion sickness; LUSC cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg24692254 chr21:30365293 RNF160 -0.54 -8.01 -0.4 1.87e-14 Dental caries; LUSC cis rs10845606 1.000 rs10845610 chr12:12839107 G/A cg04607235 chr12:12878440 APOLD1 -0.47 -5.7 -0.3 2.61e-8 Systemic lupus erythematosus; LUSC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18099408 chr3:52552593 STAB1 -0.41 -6.96 -0.36 1.84e-11 Bipolar disorder; LUSC cis rs10865397 0.539 rs13414338 chr2:73383375 C/T cg24220031 chr2:73402428 NA -0.26 -6.12 -0.32 2.6e-9 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg04267008 chr7:1944627 MAD1L1 -0.65 -10.02 -0.48 7.56e-21 Bipolar disorder and schizophrenia; LUSC cis rs9987353 0.519 rs13276350 chr8:9063157 T/C cg06636001 chr8:8085503 FLJ10661 -0.42 -5.82 -0.3 1.37e-8 Recombination measurement; LUSC cis rs7607369 0.648 rs55983650 chr2:219654932 T/C cg02176678 chr2:219576539 TTLL4 -0.7 -13.45 -0.59 2.85e-33 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7954584 0.504 rs10840633 chr12:122377511 A/T cg10207240 chr12:122356781 WDR66 0.47 6.48 0.33 3.32e-10 Mean corpuscular volume; LUSC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg21361702 chr7:150065534 REPIN1 0.45 6.28 0.33 1.03e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg12011299 chr4:100065546 ADH4 0.61 9.71 0.47 8.65e-20 Alcohol dependence; LUSC cis rs17401966 0.838 rs10864449 chr1:10296922 A/T cg19773385 chr1:10388646 KIF1B -0.52 -8.79 -0.43 7.75e-17 Hepatocellular carcinoma; LUSC cis rs2742234 0.955 rs1800861 chr10:43613843 G/T cg15436174 chr10:43711423 RASGEF1A -0.37 -6.52 -0.34 2.66e-10 Hirschsprung disease; LUSC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg04756594 chr16:24857601 SLC5A11 0.48 6.64 0.34 1.27e-10 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1559088 0.901 rs12610053 chr19:33582606 A/G cg17764715 chr19:33622953 WDR88 0.59 8.14 0.41 7.89e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs951366 0.531 rs12047038 chr1:205718468 A/G cg07157834 chr1:205819609 PM20D1 -0.44 -5.85 -0.3 1.17e-8 Menarche (age at onset); LUSC cis rs7824557 0.872 rs2572431 chr8:11105077 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.97 -0.31 6.07e-9 Retinal vascular caliber; LUSC trans rs208520 0.690 rs207096 chr6:66797287 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.61 -0.69 1.49e-49 Exhaled nitric oxide output; LUSC cis rs7568458 0.709 rs2043675 chr2:85769975 C/T cg17127132 chr2:85788382 GGCX -0.43 -6.22 -0.32 1.52e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs1728785 1.000 rs1170428 chr16:68603988 C/A cg02972257 chr16:68554789 NA -0.54 -6.73 -0.35 7.29e-11 Ulcerative colitis; LUSC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg22676075 chr6:135203613 NA 0.53 8.02 0.4 1.78e-14 Red blood cell count; LUSC cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg13395646 chr4:1353034 KIAA1530 -0.57 -8.14 -0.41 7.78e-15 Longevity; LUSC cis rs1784581 0.588 rs1789986 chr6:162409978 C/T cg17173639 chr6:162384350 PARK2 -0.56 -9.76 -0.47 5.81e-20 Itch intensity from mosquito bite; LUSC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg16325326 chr1:53192061 ZYG11B -0.88 -16.23 -0.66 4.26e-44 Monocyte count; LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs9326248 0.911 rs474339 chr11:117059552 G/A cg15534755 chr11:117069859 TAGLN 0.35 6.11 0.32 2.75e-9 Blood protein levels; LUSC cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg00677455 chr12:58241039 CTDSP2 0.71 10.92 0.51 6.17e-24 Intelligence (multi-trait analysis); LUSC cis rs7264396 0.635 rs6058344 chr20:34475038 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.41 -0.42 1.18e-15 Total cholesterol levels; LUSC cis rs4970988 0.607 rs7548516 chr1:150980281 C/T cg22823121 chr1:150693482 HORMAD1 -0.43 -5.83 -0.3 1.29e-8 Urate levels; LUSC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg19748678 chr4:122722346 EXOSC9 0.5 7.61 0.38 2.9e-13 Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05998513 chr10:97321375 SORBS1 -0.42 -6.43 -0.33 4.43e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg25319279 chr11:5960081 NA -0.41 -5.79 -0.3 1.62e-8 DNA methylation (variation); LUSC cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg12219531 chr12:120966889 COQ5 0.62 8.31 0.41 2.42e-15 High light scatter reticulocyte count; LUSC cis rs6723226 1.000 rs6723226 chr2:32849207 C/T cg02381751 chr2:32503542 YIPF4 0.55 8.28 0.41 2.92e-15 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs12598514 chr16:48689319 T/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg05234568 chr11:5960015 NA -0.59 -8.47 -0.42 7.89e-16 DNA methylation (variation); LUSC cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17159483 chr6:17600760 FAM8A1 -0.41 -6.08 -0.32 3.37e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03576123 chr11:487126 PTDSS2 -1.0 -10.66 -0.5 4.79e-23 Body mass index; LUSC cis rs6424115 0.708 rs12755062 chr1:24185025 T/A cg15997130 chr1:24165203 NA -0.48 -7.17 -0.37 4.97e-12 Immature fraction of reticulocytes; LUSC cis rs9807841 0.592 rs3810154 chr19:10764914 G/A cg17710535 chr19:10819994 QTRT1 0.41 6.78 0.35 5.45e-11 Inflammatory skin disease; LUSC cis rs12195417 0.680 rs1170465 chr6:83987655 A/C cg08257003 chr6:84140564 ME1 0.32 7.91 0.4 3.79e-14 Schizophrenia; LUSC cis rs4803468 1.000 rs284650 chr19:41927129 A/G cg09537434 chr19:41945824 ATP5SL -0.92 -16.09 -0.66 1.58e-43 Height; LUSC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg02079420 chr8:82753780 SNX16 -0.41 -7.1 -0.36 7.48e-12 Diastolic blood pressure; LUSC trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg15704280 chr7:45808275 SEPT13 0.66 7.21 0.37 3.8e-12 Axial length; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg01516881 chr6:292596 DUSP22 -0.71 -11.37 -0.53 1.56e-25 Menopause (age at onset); LUSC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg23161317 chr6:28129485 ZNF389 0.43 5.85 0.31 1.14e-8 Parkinson's disease; LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg08888203 chr3:10149979 C3orf24 0.59 8.19 0.41 5.59e-15 Alzheimer's disease; LUSC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg12615879 chr12:58013172 SLC26A10 -0.28 -5.88 -0.31 9.9e-9 Multiple sclerosis; LUSC cis rs12579753 1.000 rs11115017 chr12:82176914 C/A cg21231944 chr12:82153410 PPFIA2 -0.4 -6.11 -0.32 2.85e-9 Resting heart rate; LUSC cis rs9916302 0.821 rs4795386 chr17:37746847 A/G cg07936489 chr17:37558343 FBXL20 -0.56 -7.36 -0.37 1.41e-12 Glomerular filtration rate (creatinine); LUSC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00475322 chr7:917719 C7orf20 0.52 7.68 0.39 1.74e-13 Perceived unattractiveness to mosquitoes; LUSC cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg00933542 chr6:150070202 PCMT1 0.33 7.03 0.36 1.19e-11 Lung cancer; LUSC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg06074448 chr4:187884817 NA -0.41 -6.82 -0.35 4.28e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2282300 0.637 rs10767841 chr11:30428275 G/A cg25418670 chr11:30344373 C11orf46 -0.4 -6.24 -0.32 1.31e-9 Morning vs. evening chronotype; LUSC cis rs12989701 0.825 rs4663097 chr2:127861906 C/G cg08168897 chr2:127865431 BIN1 -0.55 -7.31 -0.37 2e-12 Alzheimer's disease (late onset); LUSC cis rs9311676 0.609 rs62258133 chr3:58398318 C/G cg26110898 chr3:58419937 PDHB 0.4 6.42 0.33 4.6e-10 Systemic lupus erythematosus; LUSC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg10523679 chr1:76189770 ACADM 0.9 16.19 0.66 6.09e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg05368731 chr17:41323189 NBR1 0.92 15.58 0.65 1.65e-41 Menopause (age at onset); LUSC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg21963583 chr11:68658836 MRPL21 0.54 8.25 0.41 3.76e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg14440974 chr22:39074834 NA -0.35 -5.93 -0.31 7.46e-9 Menopause (age at onset); LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.49 5.92 0.31 7.95e-9 Renal function-related traits (BUN); LUSC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 7.99 0.4 2.28e-14 Personality dimensions; LUSC cis rs8062405 1.000 rs55830740 chr16:28847149 G/C cg09754948 chr16:28834200 ATXN2L 0.42 6.11 0.32 2.78e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Bone mineral density; LUSC trans rs941408 1.000 rs1736179 chr19:2795516 T/A cg22153745 chr1:153894579 GATAD2B -0.53 -8.38 -0.42 1.47e-15 Total cholesterol levels; LUSC cis rs1728785 0.901 rs1645934 chr16:68564490 T/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg24324837 chr19:49891574 CCDC155 0.5 6.35 0.33 6.84e-10 Multiple sclerosis; LUSC cis rs6429082 0.713 rs867363 chr1:235579727 A/G cg26050004 chr1:235667680 B3GALNT2 -0.56 -7.94 -0.4 3.18e-14 Adiposity; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg04025307 chr7:1156635 C7orf50 0.44 6.98 0.36 1.56e-11 Longevity;Endometriosis; LUSC cis rs1729407 0.933 rs1729405 chr11:116678760 C/T cg08985259 chr11:116699649 APOC3 -0.26 -5.84 -0.3 1.26e-8 Apolipoprotein A-IV levels; LUSC cis rs7584330 0.504 rs11890255 chr2:238434605 A/G cg14458575 chr2:238380390 NA 0.42 5.83 0.3 1.3e-8 Prostate cancer; LUSC cis rs6939532 0.522 rs13218591 chr6:26376832 T/C cg09904177 chr6:26538194 HMGN4 -0.46 -6.72 -0.35 7.85e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs34779708 0.931 rs2148482 chr10:35348910 A/G cg03585969 chr10:35415529 CREM 0.63 9.14 0.45 6.16e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs977987 0.778 rs4243112 chr16:75321031 T/C cg03315344 chr16:75512273 CHST6 0.47 8.63 0.43 2.56e-16 Dupuytren's disease; LUSC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.83 -0.39 6.33e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467773 0.620 rs2494701 chr6:26634432 C/T cg11502198 chr6:26597334 ABT1 0.71 12.06 0.55 4.63e-28 Intelligence (multi-trait analysis); LUSC cis rs477692 0.583 rs12415589 chr10:131428336 C/G cg05714579 chr10:131428358 MGMT -0.77 -12.3 -0.56 6.41e-29 Response to temozolomide; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23453437 chr7:148892747 ZNF282 0.47 7.15 0.36 5.61e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7973719 0.868 rs7315553 chr12:7353838 A/C cg07052231 chr12:7363540 PEX5 0.54 9.42 0.46 7.85e-19 IgG glycosylation; LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.84 -0.57 5.91e-31 Alzheimer's disease; LUSC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.52 -0.53 4.54e-26 Schizophrenia; LUSC cis rs9473147 0.516 rs2151974 chr6:47515630 G/A cg20196966 chr6:47445060 CD2AP 0.41 5.8 0.3 1.57e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs3813567 0.702 rs7164665 chr15:78953919 T/C cg24631222 chr15:78858424 CHRNA5 0.54 6.11 0.32 2.73e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg09877947 chr5:131593287 PDLIM4 0.48 8.24 0.41 4.1e-15 Blood metabolite levels; LUSC cis rs9650315 0.659 rs13253280 chr8:57206663 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.1 -0.4 1.08e-14 Prostate cancer (SNP x SNP interaction); LUSC trans rs3774749 0.565 rs2188151 chr3:50201924 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.45 -6.81 -0.35 4.66e-11 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.593 rs59684465 chr3:49874246 C/T cg03060546 chr3:49711283 APEH -0.62 -7.28 -0.37 2.37e-12 Menarche (age at onset); LUSC cis rs12681287 0.752 rs10085920 chr8:87252666 C/T cg27223183 chr8:87520930 FAM82B -0.45 -5.72 -0.3 2.33e-8 Caudate activity during reward; LUSC cis rs6424115 0.867 rs11588187 chr1:24145047 T/A cg10978503 chr1:24200527 CNR2 0.49 11.48 0.53 5.91e-26 Immature fraction of reticulocytes; LUSC cis rs9457247 0.934 rs2345571 chr6:167403400 T/G cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.34 -0.59 7.65e-33 Alzheimer's disease; LUSC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.41 -0.38 1.03e-12 Aortic root size; LUSC cis rs11098499 0.691 rs17009144 chr4:120270795 C/T cg09307838 chr4:120376055 NA -0.59 -9.14 -0.45 6.07e-18 Corneal astigmatism; LUSC cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg00012203 chr2:219082015 ARPC2 0.72 11.88 0.54 2.21e-27 Colorectal cancer; LUSC cis rs9296092 0.521 rs56332659 chr6:33537887 T/C cg13560919 chr6:33536144 NA -0.88 -15.69 -0.65 5.8e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs4843747 0.749 rs12102841 chr16:88072574 C/G cg26811252 chr16:29126840 RRN3P2 -0.65 -10.4 -0.49 3.84e-22 Menopause (age at onset); LUSC cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs2295359 0.892 rs10889657 chr1:67615487 A/G cg12940439 chr1:67600707 NA 0.38 6.38 0.33 5.97e-10 Psoriasis; LUSC trans rs941408 0.515 rs4624312 chr19:2774460 T/C cg22153745 chr1:153894579 GATAD2B -0.49 -6.77 -0.35 5.65e-11 Total cholesterol levels; LUSC cis rs10203711 0.933 rs11883643 chr2:239586885 A/G cg14580085 chr2:239553406 NA 0.38 6.36 0.33 6.47e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1808579 0.904 rs1631685 chr18:21134239 C/T cg14672496 chr18:21087552 C18orf8 0.37 6.57 0.34 1.88e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs11785400 1.000 rs7002932 chr8:143738816 C/A cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC trans rs877282 0.898 rs11253339 chr10:759640 C/T cg22713356 chr15:30763199 NA 1.01 14.09 0.61 1.07e-35 Uric acid levels; LUSC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg21724239 chr8:58056113 NA 0.56 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); LUSC cis rs3540 0.533 rs2256110 chr15:90971036 T/C cg04176472 chr15:90893244 GABARAPL3 0.35 6.21 0.32 1.54e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6456156 0.586 rs13210649 chr6:167473193 T/G cg06454157 chr6:167490870 NA -0.27 -6.65 -0.34 1.22e-10 Primary biliary cholangitis; LUSC cis rs3740713 1.000 rs73440636 chr11:18473556 C/T cg15463284 chr11:18477534 LDHAL6A -0.5 -5.84 -0.3 1.21e-8 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs11700980 0.551 rs56263139 chr21:30109451 A/G cg14791747 chr16:20752902 THUMPD1 0.55 5.98 0.31 5.75e-9 QRS complex (12-leadsum); LUSC cis rs11098499 0.863 rs6534141 chr4:120485223 A/T cg09307838 chr4:120376055 NA 0.76 11.15 0.52 8.96e-25 Corneal astigmatism; LUSC cis rs8258 0.927 rs560355 chr11:117256384 C/G cg15227623 chr11:117232454 CEP164 0.4 5.99 0.31 5.55e-9 Pulse pressure; LUSC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg17294928 chr15:75287854 SCAMP5 -0.76 -10.07 -0.48 5.32e-21 Blood trace element (Zn levels); LUSC cis rs644799 0.582 rs1727149 chr11:95497171 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.76 -11.94 -0.55 1.33e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs62027291 0.583 rs2469195 chr15:77259486 A/G cg26408565 chr15:76604113 ETFA 0.4 5.76 0.3 1.88e-8 Plateletcrit; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14664575 chr19:40476624 PSMC4 0.37 6.09 0.32 3.18e-9 Triglycerides; LUSC cis rs6977660 0.714 rs12334267 chr7:19810265 A/G cg07541023 chr7:19748670 TWISTNB 0.61 6.6 0.34 1.61e-10 Thyroid stimulating hormone; LUSC cis rs1595825 0.891 rs79745588 chr2:198516835 G/A cg00982548 chr2:198649783 BOLL -0.52 -6.57 -0.34 1.95e-10 Ulcerative colitis; LUSC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg11062466 chr8:58055876 NA 0.51 6.96 0.36 1.84e-11 Developmental language disorder (linguistic errors); LUSC cis rs478304 0.934 rs574483 chr11:65515277 A/G cg08755490 chr11:65554678 OVOL1 0.4 5.82 0.3 1.4e-8 Acne (severe); LUSC cis rs7937682 0.593 rs1944123 chr11:111356407 T/C cg09085632 chr11:111637200 PPP2R1B 0.42 5.7 0.3 2.62e-8 Primary sclerosing cholangitis; LUSC cis rs7805747 1.000 rs10480300 chr7:151406005 C/T cg17611936 chr7:151411526 PRKAG2 0.44 5.81 0.3 1.48e-8 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); LUSC cis rs929354 0.685 rs1808217 chr7:157002741 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.21 0.59 2.34e-32 Body mass index; LUSC cis rs4242434 0.819 rs1059592 chr8:22477778 G/A cg03733263 chr8:22462867 KIAA1967 0.9 15.5 0.65 3.3e-41 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs2835872 1.000 rs1475839 chr21:39021941 C/T cg20424643 chr21:39039972 KCNJ6 0.42 6.42 0.33 4.62e-10 Electroencephalographic traits in alcoholism; LUSC cis rs7709377 0.595 rs37180 chr5:115630303 T/C cg23108291 chr5:115420582 COMMD10 -0.4 -5.71 -0.3 2.55e-8 Metabolite levels (X-11787); LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg19318889 chr4:1322082 MAEA 0.44 7.07 0.36 9.03e-12 Obesity-related traits; LUSC cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg07424592 chr7:64974309 NA 0.67 5.97 0.31 6.18e-9 Diabetic kidney disease; LUSC cis rs10992471 0.729 rs6479418 chr9:95064762 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.26 -0.41 3.42e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg26647111 chr11:31128758 NA -0.43 -6.16 -0.32 2.13e-9 Red blood cell count; LUSC cis rs9910055 0.659 rs2251165 chr17:42234748 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.29 0.45 1.98e-18 Total body bone mineral density; LUSC cis rs7590720 1.000 rs1991533 chr2:216908910 T/C cg12620499 chr2:216877984 MREG 0.91 13.45 0.59 2.9e-33 Alcohol dependence; LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg18099408 chr3:52552593 STAB1 -0.45 -7.89 -0.4 4.5e-14 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.771 rs9362237 chr6:86409064 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.53 8.31 0.41 2.36e-15 Response to antipsychotic treatment; LUSC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs73206853 0.563 rs7301623 chr12:111170903 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.51 0.38 5.32e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg08219700 chr8:58056026 NA 0.47 5.79 0.3 1.61e-8 Developmental language disorder (linguistic errors); LUSC cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg09904177 chr6:26538194 HMGN4 -0.75 -6.61 -0.34 1.51e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs983392 0.679 rs672399 chr11:60020112 T/G cg02771260 chr11:59836817 MS4A3 0.38 6.2 0.32 1.7e-9 Alzheimer's disease (late onset); LUSC cis rs6722750 0.651 rs6751738 chr2:64418379 G/T cg22352474 chr2:64371530 PELI1 -0.48 -7.19 -0.37 4.22e-12 Neuroticism; LUSC cis rs7474896 0.583 rs11011347 chr10:38019264 G/A cg25427524 chr10:38739819 LOC399744 -0.5 -6.54 -0.34 2.26e-10 Obesity (extreme); LUSC cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg22431228 chr1:16359049 CLCNKA -0.56 -12.69 -0.57 2.19e-30 Systolic blood pressure; LUSC cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg05347473 chr6:146136440 FBXO30 0.45 7.68 0.39 1.73e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg19628046 chr18:33552617 C18orf21 0.51 6.13 0.32 2.47e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg09034736 chr1:150693464 HORMAD1 0.42 5.88 0.31 9.69e-9 Melanoma; LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg22907277 chr7:1156413 C7orf50 0.5 7.87 0.4 4.84e-14 Longevity;Endometriosis; LUSC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg09044154 chr16:88155775 NA -0.53 -6.94 -0.35 2.09e-11 Menopause (age at onset); LUSC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11644478 chr21:40555479 PSMG1 0.79 14.07 0.61 1.23e-35 Cognitive function; LUSC cis rs11051970 0.636 rs2733703 chr12:32561794 C/T cg02745156 chr12:32552066 NA 0.38 6.81 0.35 4.53e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg08677398 chr8:58056175 NA 0.52 6.34 0.33 7.28e-10 Developmental language disorder (linguistic errors); LUSC cis rs4332037 0.586 rs62442944 chr7:2015047 T/G cg23422044 chr7:1970798 MAD1L1 -0.56 -6.32 -0.33 8.2e-10 Bipolar disorder; LUSC cis rs9653442 1.000 rs7580200 chr2:100811903 G/T cg07810366 chr2:100720526 AFF3 0.45 8.01 0.4 1.98e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg10802521 chr3:52805072 NEK4 -0.53 -8.5 -0.42 6.56e-16 Bipolar disorder; LUSC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg26513180 chr16:89883248 FANCA -0.54 -8.05 -0.4 1.43e-14 Vitiligo; LUSC cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Bladder cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27598656 chr16:81348532 GAN 0.43 5.95 0.31 6.66e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs800082 0.516 rs9811286 chr3:144230367 T/C cg24215973 chr2:240111563 HDAC4 0.45 6.85 0.35 3.66e-11 Smoking behavior; LUSC cis rs4947962 0.617 rs61160416 chr7:55128285 T/C cg23757825 chr7:55092271 EGFR -0.54 -6.43 -0.33 4.5e-10 Subjective response to lithium treatment; LUSC cis rs6906287 0.609 rs11153759 chr6:118920860 T/A cg21191810 chr6:118973309 C6orf204 0.32 5.96 0.31 6.53e-9 Electrocardiographic conduction measures; LUSC cis rs7568458 0.777 rs12473819 chr2:85773061 A/G cg23752985 chr2:85803571 VAMP8 0.31 6.59 0.34 1.75e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6545883 1.000 rs6545883 chr2:61772257 A/G cg15711740 chr2:61764176 XPO1 -0.45 -7.02 -0.36 1.25e-11 Tuberculosis; LUSC trans rs6601327 0.641 rs4840437 chr8:9606264 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.26 -0.32 1.16e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14737592 chr12:57914238 DDIT3 0.51 7.27 0.37 2.53e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9311676 0.632 rs56288363 chr3:58374533 A/T cg26110898 chr3:58419937 PDHB 0.42 6.74 0.35 7.17e-11 Systemic lupus erythematosus; LUSC trans rs853679 0.824 rs1321505 chr6:28052823 A/C cg06606381 chr12:133084897 FBRSL1 -0.69 -7.55 -0.38 4.06e-13 Depression; LUSC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg12560992 chr17:57184187 TRIM37 0.84 15.17 0.64 6.64e-40 Intelligence (multi-trait analysis); LUSC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg23719950 chr11:63933701 MACROD1 -0.62 -8.08 -0.4 1.21e-14 Mean platelet volume; LUSC cis rs9646944 0.501 rs10169676 chr2:103074919 G/A cg20060108 chr2:102954350 IL1RL1 0.45 6.18 0.32 1.91e-9 Blood protein levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04879387 chr16:16043101 ABCC1 -0.43 -5.99 -0.31 5.35e-9 Hepatitis; LUSC cis rs5758511 0.634 rs1001587 chr22:42670111 C/T cg00645731 chr22:42541494 CYP2D7P1 0.58 10.23 0.49 1.52e-21 Birth weight; LUSC cis rs317689 0.513 rs529268 chr12:69687051 G/A cg11871910 chr12:69753446 YEATS4 0.61 9.45 0.46 6.18e-19 Response to diuretic therapy; LUSC cis rs7843479 0.601 rs10866837 chr8:21861663 G/C cg17168535 chr8:21777572 XPO7 0.8 14.21 0.61 3.58e-36 Mean corpuscular volume; LUSC cis rs1801251 0.711 rs778368 chr2:233745333 G/C cg25237894 chr2:233734115 C2orf82 -0.34 -6.04 -0.31 4.22e-9 Coronary artery disease; LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg08200582 chr11:442649 ANO9 -0.5 -5.7 -0.3 2.7e-8 Body mass index; LUSC cis rs3760982 1.000 rs10405457 chr19:44296582 G/T cg11993925 chr19:44307056 LYPD5 0.29 6.37 0.33 6.41e-10 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg24675056 chr1:15929824 NA 0.46 8.02 0.4 1.83e-14 Systolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13965062 chr9:87284706 NTRK2 -0.57 -6.84 -0.35 3.74e-11 Bipolar disorder and schizophrenia; LUSC cis rs68170813 0.617 rs12535761 chr7:107139275 A/C cg02696742 chr7:106810147 HBP1 -0.64 -8.62 -0.43 2.66e-16 Coronary artery disease; LUSC cis rs34421088 0.532 rs2736258 chr8:11170449 C/T cg21775007 chr8:11205619 TDH 0.52 7.32 0.37 1.87e-12 Neuroticism; LUSC cis rs67460515 0.563 rs7618924 chr3:160855599 A/G cg03342759 chr3:160939853 NMD3 -0.45 -6.4 -0.33 5.33e-10 Parkinson's disease; LUSC trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg03929089 chr4:120376271 NA 0.69 7.78 0.39 9.14e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg06634786 chr22:41940651 POLR3H 0.53 6.05 0.31 3.94e-9 Vitiligo; LUSC cis rs4713675 0.584 rs9394163 chr6:33682414 A/G cg14003231 chr6:33640908 ITPR3 0.3 5.92 0.31 8.11e-9 Plateletcrit; LUSC cis rs7712401 0.601 rs446782 chr5:122341868 C/T cg19077854 chr5:122220652 SNX24 -0.43 -9.25 -0.45 2.68e-18 Mean platelet volume; LUSC cis rs2073300 1.000 rs12625160 chr20:23442008 T/C cg12062639 chr20:23401060 NAPB 0.78 6.04 0.31 4.01e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4268898 0.662 rs2303296 chr2:24432839 A/G cg06627628 chr2:24431161 ITSN2 -0.89 -13.28 -0.59 1.29e-32 Asthma; LUSC cis rs12620999 0.941 rs4663240 chr2:238036632 G/T cg23555395 chr2:238036564 NA -0.53 -8.94 -0.44 2.77e-17 Systemic lupus erythematosus; LUSC cis rs11122272 0.735 rs2250749 chr1:231485763 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.19 -0.49 2.05e-21 Hemoglobin concentration; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -9.19 -0.45 4.44e-18 Bipolar disorder and schizophrenia; LUSC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg00908189 chr16:619842 PIGQ 0.67 10.44 0.5 2.97e-22 Height; LUSC trans rs7937682 0.889 rs7926485 chr11:111536670 G/A cg18187862 chr3:45730750 SACM1L 0.55 7.04 0.36 1.11e-11 Primary sclerosing cholangitis; LUSC trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg17470723 chr8:74884337 TCEB1 0.52 8.19 0.41 5.71e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs62238980 0.614 rs77034034 chr22:32466661 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs1957429 0.901 rs1951490 chr14:65346957 G/T cg23373153 chr14:65346875 NA 1.09 12.86 0.58 4.86e-31 Pediatric areal bone mineral density (radius); LUSC trans rs2055729 0.677 rs10098618 chr8:9741478 A/T cg06636001 chr8:8085503 FLJ10661 0.49 6.38 0.33 6e-10 Multiple myeloma (hyperdiploidy); LUSC trans rs4927850 1.000 rs7625570 chr3:195747398 A/G cg16724585 chr3:197361211 NA -0.59 -8.25 -0.41 3.78e-15 Pancreatic cancer; LUSC cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg13256891 chr4:100009986 ADH5 0.48 7.11 0.36 7.05e-12 Alcohol dependence; LUSC trans rs3942852 0.568 rs10769312 chr11:48094769 C/T cg03929089 chr4:120376271 NA 0.57 7.32 0.37 1.91e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg08219700 chr8:58056026 NA 0.5 6.4 0.33 5.22e-10 Developmental language disorder (linguistic errors); LUSC cis rs56283067 0.887 rs62437973 chr6:44761978 G/A cg20913747 chr6:44695427 NA -0.48 -7.48 -0.38 6.8e-13 Total body bone mineral density; LUSC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs7824557 0.527 rs57629785 chr8:11235150 C/A cg15556689 chr8:8085844 FLJ10661 -0.49 -7.5 -0.38 5.71e-13 Retinal vascular caliber; LUSC cis rs11792861 0.781 rs72607158 chr9:111763010 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -7.25 -0.37 2.91e-12 Menarche (age at onset); LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg16405210 chr4:1374714 KIAA1530 -0.56 -8.5 -0.42 6.57e-16 Obesity-related traits; LUSC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg17747265 chr1:1875780 NA -0.73 -16.93 -0.68 7.11e-47 Body mass index; LUSC cis rs16949788 0.826 rs28723485 chr15:66624166 G/T cg08120210 chr15:66682733 MAP2K1 -0.58 -5.87 -0.31 1.06e-8 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg01579765 chr21:45077557 HSF2BP -0.55 -11.88 -0.55 2.17e-27 Mean corpuscular volume; LUSC cis rs1371867 0.846 rs1788203 chr8:101303721 T/C cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.93e-13 Atrioventricular conduction; LUSC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg07677032 chr17:61819896 STRADA 0.51 8.36 0.42 1.75e-15 Prudent dietary pattern; LUSC cis rs208520 0.674 rs207103 chr6:66795568 G/T cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -7.45 -0.38 8.32e-13 Developmental language disorder (linguistic errors); LUSC cis rs7937682 1.000 rs12363179 chr11:111568091 G/A cg22437258 chr11:111473054 SIK2 -0.48 -6.24 -0.32 1.33e-9 Primary sclerosing cholangitis; LUSC cis rs2688608 0.967 rs72814394 chr10:75656325 C/T cg17411546 chr10:75410026 SYNPO2L -0.47 -6.91 -0.35 2.4e-11 Inflammatory bowel disease; LUSC cis rs9650657 0.812 rs6601522 chr8:10629061 G/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.34 -0.33 7.37e-10 Neuroticism; LUSC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg19257562 chr1:2043853 PRKCZ 0.33 6.65 0.34 1.2e-10 Height; LUSC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg27532560 chr4:187881888 NA -0.39 -6.41 -0.33 5.1e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg23758822 chr17:41437982 NA 1.04 20.66 0.75 1.15e-61 Menopause (age at onset); LUSC trans rs35110281 0.837 rs7279968 chr21:45077398 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 9.97 0.48 1.18e-20 Mean corpuscular volume; LUSC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg20476274 chr7:133979776 SLC35B4 0.84 15.13 0.64 9.69e-40 Mean platelet volume; LUSC cis rs1865760 1.000 rs56118523 chr6:25908975 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.87 0.35 3.11e-11 Height; LUSC cis rs748404 0.697 rs524547 chr15:43551023 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 8.08 0.4 1.22e-14 Lung cancer; LUSC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg16928487 chr17:17741425 SREBF1 -0.45 -8.98 -0.44 1.95e-17 Total body bone mineral density; LUSC cis rs1865760 0.963 rs1540273 chr6:25924158 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.82 0.35 4.38e-11 Height; LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg10802521 chr3:52805072 NEK4 -0.55 -8.78 -0.43 8.48e-17 Bipolar disorder; LUSC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15506890 chr2:3487001 NA -0.58 -9.66 -0.47 1.27e-19 Neurofibrillary tangles; LUSC cis rs4889855 0.614 rs7208670 chr17:78494220 T/G cg16591659 chr17:78472290 NA -0.46 -7.46 -0.38 7.41e-13 Fractional excretion of uric acid; LUSC cis rs1568889 0.838 rs10835276 chr11:28167147 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.56 0.57 6.54e-30 Bipolar disorder; LUSC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg22968622 chr17:43663579 NA 0.8 12.27 0.56 7.9e-29 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg06740227 chr12:86229804 RASSF9 0.38 6.11 0.32 2.83e-9 Major depressive disorder; LUSC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.16 0.55 2.1e-28 Menopause (age at onset); LUSC trans rs8072100 0.967 rs7219303 chr17:45737701 A/G cg03886242 chr7:26192032 NFE2L3 0.37 6.18 0.32 1.83e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2271400 0.603 rs182832 chr8:56790861 G/T cg08894788 chr8:56792171 LYN 0.45 6.0 0.31 5e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Myeloid white cell count;Neutrophil count;Granulocyte count; LUSC cis rs2398893 0.855 rs11791859 chr9:96788758 G/A cg14459158 chr9:96720562 NA 0.3 5.88 0.31 9.85e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg20887711 chr4:1340912 KIAA1530 0.46 7.16 0.36 5.1e-12 Obesity-related traits; LUSC cis rs2219968 0.887 rs67368685 chr8:78966267 A/G cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9300255 0.602 rs941305 chr12:123715266 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.22 -0.32 1.48e-9 Neutrophil percentage of white cells; LUSC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg26408565 chr15:76604113 ETFA -0.5 -8.0 -0.4 2.04e-14 Blood metabolite levels; LUSC cis rs7264396 0.836 rs2010565 chr20:34182517 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -7.56 -0.38 3.84e-13 Total cholesterol levels; LUSC cis rs6901250 0.569 rs621486 chr6:117089143 T/C cg12892004 chr6:117198278 RFX6 0.36 6.56 0.34 2.02e-10 C-reactive protein levels; LUSC cis rs67460515 0.563 rs1585481 chr3:160901481 C/T cg03342759 chr3:160939853 NMD3 -0.43 -6.26 -0.32 1.17e-9 Parkinson's disease; LUSC cis rs1322512 1.000 rs2800632 chr6:153008632 C/A cg03415253 chr6:152958462 SYNE1 0.38 5.66 0.3 3.19e-8 Tonometry; LUSC cis rs4654899 0.802 rs12401413 chr1:21236503 T/C cg01072550 chr1:21505969 NA -0.47 -6.81 -0.35 4.51e-11 Superior frontal gyrus grey matter volume; LUSC cis rs2839186 0.967 rs9637172 chr21:47685787 T/C cg05896524 chr21:47604654 C21orf56 0.42 6.22 0.32 1.49e-9 Testicular germ cell tumor; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19648955 chr2:177134095 MTX2 -0.42 -6.3 -0.33 9.64e-10 Electrocardiographic conduction measures; LUSC cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg17366294 chr4:99064904 C4orf37 0.56 10.16 0.49 2.62e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg00484396 chr16:3507460 NAT15 0.48 7.15 0.36 5.34e-12 Body mass index (adult); LUSC cis rs7605827 0.930 rs11694458 chr2:15530469 C/G cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs7568458 0.660 rs6547623 chr2:85801964 T/A cg23752985 chr2:85803571 VAMP8 0.33 6.45 0.33 3.97e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2414856 0.510 rs72758907 chr15:64638559 G/A cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs13315871 0.932 rs35741271 chr3:58323091 A/G cg12435725 chr3:58293450 RPP14 -0.72 -7.15 -0.36 5.35e-12 Cholesterol, total; LUSC cis rs11039100 0.541 rs11038949 chr11:5780198 A/T cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.91 13.27 0.59 1.38e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg15445000 chr17:37608096 MED1 -0.39 -6.71 -0.34 8.49e-11 Glomerular filtration rate (creatinine); LUSC cis rs13427251 0.692 rs10206082 chr2:100160024 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.47 -6.75 -0.35 6.61e-11 Chronic sinus infection; LUSC cis rs2220004 0.507 rs11231560 chr11:55689699 C/G cg22937354 chr11:55606216 OR5D16 -0.37 -5.75 -0.3 2.07e-8 Odorant perception (&beta-damascenone); LUSC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg13628971 chr7:2884303 GNA12 0.39 6.09 0.32 3.05e-9 Height; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.79e-30 Prudent dietary pattern; LUSC cis rs72781680 0.848 rs56021814 chr2:24073437 T/A cg20701182 chr2:24300061 SF3B14 0.56 6.03 0.31 4.32e-9 Lymphocyte counts; LUSC cis rs1982963 0.627 rs2073626 chr14:52488385 A/G cg10843707 chr14:52510701 NID2 0.46 6.36 0.33 6.66e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg14541582 chr5:601475 NA -0.38 -5.93 -0.31 7.36e-9 Lung disease severity in cystic fibrosis; LUSC cis rs925550 0.627 rs1398559 chr4:123593320 A/G cg10495464 chr4:123653540 BBS12;LOC729338 -0.48 -5.71 -0.3 2.53e-8 Primary biliary cholangitis; LUSC cis rs9462027 0.561 rs2262245 chr6:34567694 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.9 -0.31 8.96e-9 Systemic lupus erythematosus; LUSC cis rs2455601 0.744 rs11042133 chr11:8966511 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -7.2 -0.37 4.06e-12 Schizophrenia; LUSC cis rs7589342 0.507 rs6543338 chr2:106403911 C/G cg09152813 chr2:106391379 NCK2 -0.37 -5.8 -0.3 1.58e-8 Addiction; LUSC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.29e-12 Developmental language disorder (linguistic errors); LUSC cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg18655438 chr5:1077845 SLC12A7 -0.35 -5.74 -0.3 2.15e-8 QT interval; LUSC cis rs2120019 0.508 rs8030528 chr15:75171825 C/T cg17294928 chr15:75287854 SCAMP5 -0.75 -8.76 -0.43 9.88e-17 Blood trace element (Zn levels); LUSC cis rs1577917 0.771 rs12199873 chr6:86294947 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.68 -10.82 -0.51 1.33e-23 Response to antipsychotic treatment; LUSC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg09365446 chr1:150670422 GOLPH3L 0.46 6.67 0.34 1.07e-10 Melanoma; LUSC trans rs11098499 0.863 rs7699064 chr4:120428309 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.46 -6.2 -0.32 1.67e-9 Corneal astigmatism; LUSC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg01448562 chr3:133502909 NA -0.66 -10.66 -0.5 5.08e-23 Iron status biomarkers; LUSC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg06481639 chr22:41940642 POLR3H -0.51 -6.17 -0.32 1.98e-9 Vitiligo; LUSC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg00310523 chr12:86230176 RASSF9 -0.43 -7.93 -0.4 3.28e-14 Major depressive disorder; LUSC cis rs9650657 0.665 rs7002117 chr8:10616169 A/G cg27411982 chr8:10470053 RP1L1 0.4 6.28 0.32 1.07e-9 Neuroticism; LUSC cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg03354898 chr7:1950403 MAD1L1 -0.44 -9.18 -0.45 4.67e-18 Bipolar disorder and schizophrenia; LUSC cis rs2798269 0.867 rs11840168 chr13:22118302 A/G cg18095732 chr13:22033692 ZDHHC20 -0.4 -6.23 -0.32 1.44e-9 PR segment; LUSC cis rs78663649 0.708 rs79268770 chr19:16601411 A/T cg10248733 chr19:16607483 C19orf44;CALR3 -0.88 -6.34 -0.33 7.41e-10 White blood cell count; LUSC cis rs8062405 0.723 rs4788077 chr16:28569764 G/C cg07382826 chr16:28625726 SULT1A1 0.28 6.0 0.31 5.21e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg12432903 chr7:1882776 MAD1L1 0.51 6.24 0.32 1.34e-9 Bipolar disorder; LUSC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg27494647 chr7:150038898 RARRES2 -0.48 -7.32 -0.37 1.82e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs2439831 0.850 rs3759790 chr15:44121030 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.84 8.34 0.42 1.92e-15 Lung cancer in ever smokers; LUSC trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.51 0.67 3.48e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4343996 0.521 rs10278205 chr7:3424878 C/T cg21248987 chr7:3385318 SDK1 0.37 6.3 0.33 9.65e-10 Motion sickness; LUSC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg15369054 chr17:80825471 TBCD 0.7 11.38 0.53 1.36e-25 Breast cancer; LUSC cis rs708547 0.874 rs1718868 chr4:57881215 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.63 -0.34 1.39e-10 Response to bleomycin (chromatid breaks); LUSC trans rs62238980 0.614 rs77630998 chr22:32452744 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs11997175 0.624 rs7001604 chr8:33680979 T/C ch.8.33884649F chr8:33765107 NA 0.48 7.11 0.36 6.95e-12 Body mass index; LUSC cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg24450063 chr1:156163899 SLC25A44 0.92 14.18 0.61 4.64e-36 Testicular germ cell tumor; LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg07362569 chr17:61921086 SMARCD2 0.38 7.84 0.39 6.15e-14 Prudent dietary pattern; LUSC cis rs1113500 0.933 rs10881500 chr1:108638895 C/T cg06207961 chr1:108661230 NA 0.41 7.64 0.39 2.27e-13 Growth-regulated protein alpha levels; LUSC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg12923728 chr3:195709715 SDHAP1 -0.79 -12.37 -0.56 3.46e-29 Pancreatic cancer; LUSC trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.61 0.34 1.55e-10 Intraocular pressure; LUSC cis rs2282300 0.956 rs1717779 chr11:30376698 A/T cg25418670 chr11:30344373 C11orf46 -0.53 -7.47 -0.38 6.97e-13 Morning vs. evening chronotype; LUSC cis rs2262909 0.962 rs73021832 chr19:22316144 G/C cg11619707 chr19:22235551 ZNF257 0.41 6.13 0.32 2.48e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg22823121 chr1:150693482 HORMAD1 0.52 7.68 0.39 1.83e-13 Melanoma; LUSC cis rs2425143 1.000 rs12479473 chr20:34398628 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -5.93 -0.31 7.7e-9 Blood protein levels; LUSC cis rs9287719 0.934 rs10201077 chr2:10752426 A/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs9463078 0.683 rs227850 chr6:44699068 C/T cg25276700 chr6:44698697 NA 0.29 5.82 0.3 1.38e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs12367572 0.930 rs10880695 chr12:45233261 T/C cg04608330 chr12:45269318 NELL2 -0.54 -8.49 -0.42 6.68e-16 Gut microbiome composition (summer); LUSC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg02951883 chr7:2050386 MAD1L1 -0.58 -10.63 -0.5 6.39e-23 Bipolar disorder and schizophrenia; LUSC cis rs899997 1.000 rs11634628 chr15:79005579 G/A cg24631222 chr15:78858424 CHRNA5 -0.42 -5.72 -0.3 2.42e-8 Coronary artery disease or large artery stroke; LUSC cis rs73200209 0.744 rs7959347 chr12:116479781 A/G cg01776926 chr12:116560359 MED13L -0.5 -5.97 -0.31 6.1e-9 Total body bone mineral density; LUSC cis rs7112043 0.838 rs11032839 chr11:34777725 A/G cg06937548 chr11:34938143 PDHX;APIP 0.41 5.96 0.31 6.46e-9 Lung disease severity in cystic fibrosis; LUSC cis rs16976116 0.901 rs1061870 chr15:55496769 G/T cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg06544989 chr22:39130855 UNC84B 0.37 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs7267979 1.000 rs2482927 chr20:25327151 T/C cg03522245 chr20:25566470 NINL -0.36 -5.81 -0.3 1.43e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7189233 0.531 rs17801498 chr16:53513452 C/G cg09728985 chr16:53543985 NA -0.33 -6.31 -0.33 8.79e-10 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.545 rs12600062 chr16:68287544 C/A cg09835421 chr16:68378352 PRMT7 -0.7 -7.06 -0.36 9.98e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg15556689 chr8:8085844 FLJ10661 -0.63 -10.2 -0.49 1.93e-21 Joint mobility (Beighton score); LUSC cis rs611744 0.625 rs11779824 chr8:109278689 G/A cg18478394 chr8:109455254 TTC35 0.42 6.53 0.34 2.38e-10 Dupuytren's disease; LUSC cis rs3849570 0.565 rs1851926 chr3:81977231 A/C cg07356753 chr3:81810745 GBE1 -0.49 -7.25 -0.37 2.95e-12 Waist circumference;Body mass index; LUSC cis rs7020830 0.825 rs66684257 chr9:37199087 G/T cg14294708 chr9:37120828 ZCCHC7 1.02 22.37 0.77 2.28e-68 Schizophrenia; LUSC cis rs2742417 0.603 rs2253979 chr3:45773320 A/G cg04837898 chr3:45731254 SACM1L -0.45 -7.25 -0.37 2.97e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9790314 0.967 rs6762645 chr3:160948349 T/G cg04691961 chr3:161091175 C3orf57 -0.35 -5.97 -0.31 5.9e-9 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg07677032 chr17:61819896 STRADA 0.55 9.09 0.45 9.21e-18 Prudent dietary pattern; LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg13047869 chr3:10149882 C3orf24 0.61 8.27 0.41 3.18e-15 Alzheimer's disease; LUSC cis rs2692947 0.770 rs72492163 chr2:96417816 G/A cg23100626 chr2:96804247 ASTL 0.29 6.89 0.35 2.78e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10740039 0.810 rs9415605 chr10:62376567 T/C cg18175470 chr10:62150864 ANK3 0.46 6.57 0.34 1.98e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4629710 0.617 rs28360555 chr6:131538952 C/A cg12606694 chr6:131520996 AKAP7 0.61 9.29 0.45 2.09e-18 Multiple myeloma (IgH translocation); LUSC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.87 0.44 4.57e-17 Menopause (age at onset); LUSC cis rs12900413 0.687 rs12913409 chr15:90319251 T/A cg24249390 chr15:90295951 MESP1 -0.37 -5.85 -0.31 1.15e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9463078 0.528 rs13211229 chr6:44912462 G/A cg25276700 chr6:44698697 NA 0.29 5.9 0.31 8.99e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg15839431 chr19:19639596 YJEFN3 0.6 6.43 0.33 4.29e-10 Bipolar disorder; LUSC cis rs2243480 1.000 rs4718269 chr7:65200778 C/G cg18252515 chr7:66147081 NA 1.13 12.77 0.57 1.1e-30 Diabetic kidney disease; LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg13707768 chr11:65081977 CDC42EP2 -0.55 -5.96 -0.31 6.49e-9 Schizophrenia; LUSC cis rs12618769 0.597 rs11902825 chr2:99129137 T/C cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs7177699 0.557 rs9920493 chr15:79113846 A/C cg15571903 chr15:79123663 NA 0.32 5.9 0.31 9.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1843834 0.898 rs4674936 chr2:225553731 C/T cg22455342 chr2:225449267 CUL3 0.46 6.13 0.32 2.41e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs2717559 0.542 rs2585156 chr8:143879795 G/A cg02415014 chr8:143852576 LYNX1 0.32 7.47 0.38 6.92e-13 Urinary tract infection frequency; LUSC cis rs11828289 0.599 rs75341566 chr11:23186941 C/A cg20040320 chr11:23191996 NA -0.58 -6.1 -0.32 2.95e-9 Cancer; LUSC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg11584989 chr19:19387371 SF4 0.57 6.92 0.35 2.31e-11 Bipolar disorder; LUSC cis rs9902453 0.904 rs7208579 chr17:28263067 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.79 0.51 1.7e-23 Coffee consumption (cups per day); LUSC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.84 10.52 0.5 1.54e-22 Gut microbiome composition (summer); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17660682 chr3:167452753 PDCD10;SERPINI1 -0.42 -6.02 -0.31 4.48e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11779988 0.545 rs208763 chr8:17806482 G/A cg01800426 chr8:17659068 MTUS1 -0.47 -5.91 -0.31 8.27e-9 Breast cancer; LUSC cis rs4319547 0.695 rs6488958 chr12:122880704 A/G cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.22 -0.41 4.63e-15 Body mass index; LUSC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13636640 chr20:31349939 DNMT3B 0.92 17.88 0.7 1.26e-50 Ulcerative colitis; LUSC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg06544989 chr22:39130855 UNC84B 0.33 5.79 0.3 1.65e-8 Menopause (age at onset); LUSC cis rs7681423 1.000 rs12644950 chr4:155537321 G/A cg20735720 chr4:155535218 FGG -0.47 -6.88 -0.35 2.92e-11 Fibrinogen; LUSC trans rs17780086 0.527 rs72827712 chr17:30538600 A/G cg27661571 chr11:113659931 NA -0.64 -6.02 -0.31 4.61e-9 Height; LUSC cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.55e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 1.000 rs7819412 chr8:11045161 A/G cg08975724 chr8:8085496 FLJ10661 0.44 6.32 0.33 8.39e-10 Triglycerides; LUSC cis rs4888262 0.545 rs4888270 chr16:74698576 A/G cg01733217 chr16:74700730 RFWD3 0.78 13.23 0.59 2.08e-32 Testicular germ cell tumor; LUSC cis rs6982240 0.514 rs11785274 chr8:142261541 G/A cg00131261 chr8:142287264 NA -0.37 -6.12 -0.32 2.59e-9 Tonsillectomy; LUSC cis rs7647973 1.000 rs940045 chr3:49449638 G/A cg07636037 chr3:49044803 WDR6 0.7 9.5 0.46 4.11e-19 Menarche (age at onset); LUSC cis rs2952156 0.916 rs903506 chr17:37879762 G/A cg00129232 chr17:37814104 STARD3 -0.47 -6.84 -0.35 3.76e-11 Asthma; LUSC cis rs7296418 0.961 rs10773921 chr12:123541606 C/T cg05973401 chr12:123451056 ABCB9 0.65 9.49 0.46 4.49e-19 Platelet count; LUSC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs4704187 0.687 rs1600074 chr5:74436574 C/T cg03227963 chr5:74354835 NA 0.3 6.48 0.33 3.2e-10 Response to amphetamines; LUSC cis rs909341 0.678 rs6011018 chr20:62303622 T/G cg09650180 chr20:62225654 GMEB2 0.45 5.9 0.31 8.83e-9 Atopic dermatitis; LUSC cis rs73206853 0.764 rs73191817 chr12:110918673 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7267979 0.586 rs6050439 chr20:25192331 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.8 0.57 8.58e-31 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11158026 0.574 rs7152033 chr14:55392754 C/T cg04306507 chr14:55594613 LGALS3 0.35 6.11 0.32 2.73e-9 Parkinson's disease; LUSC cis rs1065656 0.563 rs391546 chr16:1915581 T/G cg00564555 chr16:1970112 NA 0.37 6.12 0.32 2.64e-9 Insulin-like growth factors; LUSC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg22532475 chr10:104410764 TRIM8 -0.32 -6.91 -0.35 2.48e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs651907 0.514 rs34301719 chr3:101417993 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 11.84 0.54 3.05e-27 Colorectal cancer; LUSC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg21724239 chr8:58056113 NA 0.61 7.07 0.36 8.99e-12 Developmental language disorder (linguistic errors); LUSC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.96 0.36 1.76e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4969178 0.965 rs3744217 chr17:76400258 G/A cg05887092 chr17:76393375 PGS1 0.51 9.08 0.44 9.91e-18 HDL cholesterol levels; LUSC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg23758822 chr17:41437982 NA 1.04 19.49 0.73 4.77e-57 Menopause (age at onset); LUSC cis rs7614311 0.681 rs73117042 chr3:63896543 T/C cg22134162 chr3:63841271 THOC7 -0.5 -6.19 -0.32 1.79e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.44 0.53 8.39e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.59 -8.1 -0.41 1.07e-14 Renal function-related traits (BUN); LUSC cis rs9325144 0.560 rs6582539 chr12:38630097 C/T cg13010199 chr12:38710504 ALG10B -0.55 -8.39 -0.42 1.43e-15 Morning vs. evening chronotype; LUSC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg24675658 chr1:53192096 ZYG11B -0.68 -11.0 -0.52 3.14e-24 Monocyte count; LUSC cis rs72781680 0.898 rs12612492 chr2:24093756 C/T cg08917208 chr2:24149416 ATAD2B 0.95 10.6 0.5 8.16e-23 Lymphocyte counts; LUSC cis rs3772130 0.564 rs9817555 chr3:121406327 G/A cg20356878 chr3:121714668 ILDR1 0.55 8.9 0.44 3.7e-17 Cognitive performance; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg13560548 chr3:10150139 C3orf24 0.46 6.6 0.34 1.61e-10 Alzheimer's disease; LUSC trans rs2562456 0.520 rs582992 chr19:21449546 G/T cg00806126 chr19:22604979 ZNF98 0.42 5.95 0.31 6.59e-9 Pain; LUSC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.7 10.76 0.51 2.14e-23 Lymphocyte counts; LUSC cis rs1950626 0.577 rs35097045 chr14:101454403 G/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.48 0.38 6.57e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg14019146 chr3:50243930 SLC38A3 -0.32 -7.0 -0.36 1.37e-11 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg21918786 chr6:109611834 NA 0.36 6.05 0.31 3.86e-9 Reticulocyte fraction of red cells; LUSC cis rs4555082 0.834 rs4412909 chr14:105759226 T/C cg27165867 chr14:105738592 BRF1 -0.5 -7.3 -0.37 2.16e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs892961 0.932 rs66886702 chr17:75412714 G/A cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs62432291 0.681 rs2501177 chr6:159655593 C/T cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg13531842 chr10:38383804 ZNF37A -0.44 -6.72 -0.35 7.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg20684491 chr1:25596433 NA 0.37 5.79 0.3 1.61e-8 Plateletcrit;Mean corpuscular volume; LUSC cis rs2692947 0.759 rs1917890 chr2:96672001 C/T cg23100626 chr2:96804247 ASTL 0.26 6.46 0.33 3.66e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg06784218 chr1:46089804 CCDC17 0.56 11.2 0.52 6.35e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs10090774 0.965 rs11167016 chr8:141995180 A/G cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 5.98 0.31 5.63e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.51 7.31 0.37 1.94e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg24829409 chr8:58192753 C8orf71 -0.59 -6.07 -0.32 3.53e-9 Developmental language disorder (linguistic errors); LUSC cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg06784218 chr1:46089804 CCDC17 -0.54 -11.17 -0.52 8.04e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7772486 0.875 rs1412080 chr6:146417304 T/C cg05347473 chr6:146136440 FBXO30 0.49 8.23 0.41 4.25e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2760061 0.505 rs708109 chr1:228190657 C/T cg04850211 chr1:228464232 OBSCN -0.37 -6.2 -0.32 1.62e-9 Diastolic blood pressure; LUSC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg00800038 chr16:89945340 TCF25 -0.75 -6.58 -0.34 1.83e-10 Skin colour saturation; LUSC cis rs7107174 1.000 rs2510035 chr11:77953175 A/C cg02023728 chr11:77925099 USP35 0.51 7.06 0.36 9.76e-12 Testicular germ cell tumor; LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.88 -12.17 -0.55 1.89e-28 Platelet count; LUSC cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg18252515 chr7:66147081 NA 1.33 14.25 0.61 2.44e-36 Diabetic kidney disease; LUSC cis rs6582630 0.504 rs4882367 chr12:38330878 A/T cg26384229 chr12:38710491 ALG10B -0.53 -7.82 -0.39 6.86e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs1106634 0.748 rs79915075 chr8:20065641 A/G cg17327115 chr8:20112950 LZTS1 0.56 5.65 0.3 3.38e-8 Bipolar disorder and schizophrenia;Major depressive disorder (broad); LUSC cis rs4363385 0.747 rs6668215 chr1:152964498 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.65 -0.39 2.16e-13 Inflammatory skin disease; LUSC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg18252515 chr7:66147081 NA -1.22 -13.35 -0.59 7.04e-33 Diabetic kidney disease; LUSC cis rs11785400 0.793 rs9774627 chr8:143731267 G/A cg24634471 chr8:143751801 JRK 0.51 7.25 0.37 2.97e-12 Schizophrenia; LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg04267008 chr7:1944627 MAD1L1 -0.6 -9.14 -0.45 6.04e-18 Bipolar disorder and schizophrenia; LUSC cis rs4595586 0.525 rs12825567 chr12:39386621 C/T cg26384229 chr12:38710491 ALG10B 0.48 6.93 0.35 2.23e-11 Morning vs. evening chronotype; LUSC trans rs7726839 0.574 rs11739866 chr5:636299 C/T cg25482853 chr8:67687455 SGK3 1.11 15.38 0.64 9.94e-41 Obesity-related traits; LUSC trans rs9329221 0.537 rs6995859 chr8:9975709 T/A cg15556689 chr8:8085844 FLJ10661 0.52 7.78 0.39 9.42e-14 Neuroticism; LUSC cis rs1371867 0.846 rs924057 chr8:101266157 A/G cg00191853 chr8:101177733 SPAG1 0.34 5.78 0.3 1.74e-8 Atrioventricular conduction; LUSC cis rs17621444 0.522 rs4237513 chr10:121810241 C/T cg02041677 chr10:121771263 NA -0.33 -6.35 -0.33 7.16e-10 IgG glycosylation; LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg08888203 chr3:10149979 C3orf24 0.63 8.8 0.43 7.4e-17 Alzheimer's disease; LUSC cis rs7582720 1.000 rs72926802 chr2:203830228 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs11997175 0.625 rs4733172 chr8:33618049 T/C ch.8.33884649F chr8:33765107 NA 0.44 7.09 0.36 7.9e-12 Body mass index; LUSC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg03060546 chr3:49711283 APEH 0.68 7.67 0.39 1.84e-13 Menarche (age at onset); LUSC cis rs478304 0.934 rs498354 chr11:65528213 A/G cg08755490 chr11:65554678 OVOL1 0.4 5.82 0.3 1.4e-8 Acne (severe); LUSC trans rs9929218 0.954 rs2059254 chr16:68817439 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.59 -0.54 2.45e-26 Colorectal cancer; LUSC cis rs8114671 0.562 rs1801310 chr20:33517014 A/G cg24642439 chr20:33292090 TP53INP2 0.45 6.49 0.33 3.09e-10 Height; LUSC cis rs11122272 0.735 rs2749716 chr1:231486908 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.73 -0.47 7.36e-20 Hemoglobin concentration; LUSC cis rs34779708 0.801 rs34592588 chr10:35540134 A/G cg03585969 chr10:35415529 CREM 0.55 7.67 0.39 1.92e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs79911532 0.515 rs76760929 chr7:75625968 T/G cg03592824 chr7:75666768 STYXL1 0.7 6.98 0.36 1.56e-11 Mononucleosis; LUSC cis rs9865818 0.702 rs4686484 chr3:188118572 G/A cg23651889 chr3:188115336 LPP -0.39 -5.97 -0.31 6.18e-9 Allergic sensitization; LUSC cis rs735860 0.726 rs209517 chr6:53206989 A/T cg10236188 chr6:53219634 NA 0.39 5.91 0.31 8.47e-9 Glaucoma; LUSC cis rs7072216 0.666 rs11598689 chr10:100156027 G/T cg26618903 chr10:100175079 PYROXD2 -0.37 -6.29 -0.33 1.02e-9 Metabolite levels; LUSC cis rs12980942 0.872 rs12327659 chr19:41796472 A/G cg25627403 chr19:41769009 HNRNPUL1 0.58 6.43 0.33 4.53e-10 Coronary artery disease; LUSC trans rs61931739 0.635 rs7979207 chr12:33910566 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.69 -0.39 1.66e-13 Morning vs. evening chronotype; LUSC cis rs7681440 0.904 rs28507349 chr4:90767063 G/A cg01966878 chr4:90757139 SNCA -0.36 -6.22 -0.32 1.48e-9 Dementia with Lewy bodies; LUSC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.92 15.67 0.65 7.38e-42 Platelet count; LUSC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18099408 chr3:52552593 STAB1 -0.41 -7.08 -0.36 8.51e-12 Electroencephalogram traits; LUSC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg12963246 chr6:28129442 ZNF389 0.51 7.37 0.37 1.33e-12 Parkinson's disease; LUSC trans rs61931739 0.613 rs4931773 chr12:33749131 G/A cg26384229 chr12:38710491 ALG10B 0.43 6.28 0.32 1.03e-9 Morning vs. evening chronotype; LUSC cis rs870825 0.929 rs72689260 chr4:185590656 G/T cg04058563 chr4:185651563 MLF1IP 0.83 11.29 0.53 2.87e-25 Blood protein levels; LUSC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg05347473 chr6:146136440 FBXO30 0.63 10.93 0.51 5.5e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs68170813 0.559 rs77150993 chr7:106817100 G/T cg02696742 chr7:106810147 HBP1 -0.65 -9.7 -0.47 9.21e-20 Coronary artery disease; LUSC trans rs72674100 1.000 rs72882341 chr4:97993768 G/C cg09670535 chr1:18959427 PAX7 -0.61 -6.23 -0.32 1.41e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12893668 0.638 rs11851616 chr14:104065600 G/A cg04998671 chr14:104000505 TRMT61A -0.42 -6.11 -0.32 2.81e-9 Reticulocyte count; LUSC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg18758796 chr5:131593413 PDLIM4 -0.4 -6.28 -0.33 1.04e-9 Breast cancer; LUSC cis rs1577917 0.958 rs34765423 chr6:86484448 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.04 -0.36 1.08e-11 Response to antipsychotic treatment; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg20887711 chr4:1340912 KIAA1530 0.43 6.71 0.34 8.33e-11 Obesity-related traits; LUSC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg03264133 chr6:25882463 NA 0.61 10.19 0.49 2.08e-21 Blood metabolite levels; LUSC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg04944784 chr2:26401820 FAM59B -0.67 -9.71 -0.47 8.72e-20 Gut microbiome composition (summer); LUSC cis rs12893668 0.703 rs7140568 chr14:104041374 C/T cg04998671 chr14:104000505 TRMT61A -0.48 -6.71 -0.34 8.58e-11 Reticulocyte count; LUSC trans rs61931739 0.500 rs11519123 chr12:34436478 A/G cg13010199 chr12:38710504 ALG10B 0.58 9.23 0.45 3.24e-18 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg08798685 chr6:27730294 NA -0.64 -5.76 -0.3 1.92e-8 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; LUSC cis rs3772130 0.603 rs35489993 chr3:121411876 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.74 11.71 0.54 9.04e-27 Cognitive performance; LUSC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg03605463 chr16:89740564 NA 0.53 8.49 0.42 7.05e-16 Hemoglobin concentration; LUSC cis rs2835872 0.737 rs1787404 chr21:39049362 C/T cg20424643 chr21:39039972 KCNJ6 0.41 6.6 0.34 1.62e-10 Electroencephalographic traits in alcoholism; LUSC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg00647820 chr17:40259828 DHX58 0.47 6.54 0.34 2.27e-10 Fibrinogen levels; LUSC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg05234568 chr11:5960015 NA -0.59 -8.46 -0.42 8.25e-16 DNA methylation (variation); LUSC cis rs11971779 0.616 rs11771715 chr7:139027496 T/C cg23387468 chr7:139079360 LUC7L2 0.4 6.01 0.31 4.77e-9 Diisocyanate-induced asthma; LUSC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg17385448 chr1:15911702 AGMAT 0.35 5.93 0.31 7.36e-9 Systolic blood pressure; LUSC trans rs56114371 0.777 rs200481 chr6:27773832 A/T cg06606381 chr12:133084897 FBRSL1 -0.72 -7.47 -0.38 7.22e-13 Breast cancer; LUSC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg11062466 chr8:58055876 NA 0.71 8.53 0.42 5.07e-16 Developmental language disorder (linguistic errors); LUSC trans rs9393777 0.920 rs66462181 chr6:27091661 T/C cg01620082 chr3:125678407 NA -0.75 -6.29 -0.33 9.67e-10 Intelligence (multi-trait analysis); LUSC cis rs117352156 0.943 rs12411424 chr10:29214344 G/T cg06394621 chr10:29236369 NA -0.47 -6.34 -0.33 7.38e-10 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7072216 0.843 rs4400721 chr10:100147097 C/T cg19567339 chr10:100142640 NA 0.36 5.67 0.3 3.07e-8 Metabolite levels; LUSC cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg00639195 chr15:79103007 ADAMTS7 0.46 6.87 0.35 3.19e-11 Diastolic blood pressure; LUSC cis rs10779751 0.708 rs2746640 chr1:11292952 T/A cg08854313 chr1:11322531 MTOR 0.87 14.02 0.61 1.91e-35 Body mass index; LUSC cis rs1595825 0.636 rs111540926 chr2:198885578 G/A cg00982548 chr2:198649783 BOLL -0.54 -6.93 -0.35 2.2e-11 Ulcerative colitis; LUSC cis rs6840360 0.593 rs10013612 chr4:152693622 A/G cg22705602 chr4:152727874 NA -0.39 -8.43 -0.42 1.06e-15 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs6050559 chr20:25329915 A/G cg08601574 chr20:25228251 PYGB 0.43 6.7 0.34 8.76e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11098499 0.954 rs13133522 chr4:120324424 A/T cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg13206674 chr6:150067644 NUP43 0.45 6.28 0.33 1.03e-9 Testicular germ cell tumor; LUSC cis rs2797160 1.000 rs2211420 chr6:125995549 A/G cg05901451 chr6:126070800 HEY2 -0.59 -8.89 -0.44 3.97e-17 Endometrial cancer; LUSC cis rs2445762 0.518 rs8043240 chr15:51635565 C/T cg00184732 chr15:51633821 GLDN 0.3 5.9 0.31 8.99e-9 Hormone measurements; LUSC cis rs61935443 0.720 rs10859780 chr12:95282601 T/C cg21533806 chr12:95267307 NA 0.51 6.39 0.33 5.53e-10 Schizophrenia; LUSC cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg25801113 chr15:45476975 SHF 0.36 7.32 0.37 1.82e-12 Uric acid levels; LUSC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg25427524 chr10:38739819 LOC399744 -0.67 -12.09 -0.55 3.73e-28 Extrinsic epigenetic age acceleration; LUSC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg12639453 chr1:2035780 PRKCZ -0.3 -6.41 -0.33 5.06e-10 Height; LUSC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg24209194 chr3:40518798 ZNF619 0.47 6.52 0.34 2.53e-10 Renal cell carcinoma; LUSC cis rs5769765 0.542 rs761878 chr22:50249677 A/G cg02269571 chr22:50332266 NA 0.59 7.55 0.38 4.13e-13 Schizophrenia; LUSC cis rs7474896 0.559 rs1735629 chr10:38178309 C/T cg25427524 chr10:38739819 LOC399744 0.45 5.83 0.3 1.34e-8 Obesity (extreme); LUSC cis rs6669072 0.647 rs814547 chr1:91238821 T/C cg08895590 chr1:91227319 NA -0.38 -8.6 -0.43 3.23e-16 Cognitive function; LUSC cis rs11039100 0.850 rs11039168 chr11:5844723 C/A cg05234568 chr11:5960015 NA -0.52 -5.85 -0.31 1.14e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7818345 0.874 rs56298301 chr8:19305937 C/A cg11303988 chr8:19266685 CSGALNACT1 0.32 6.08 0.32 3.34e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.61 0.6 7.25e-34 Platelet count; LUSC cis rs12618769 0.947 rs3769695 chr2:99259020 G/T cg10123293 chr2:99228465 UNC50 0.43 5.99 0.31 5.36e-9 Bipolar disorder; LUSC cis rs6426558 0.537 rs12139758 chr1:227260519 A/G cg10327440 chr1:227177885 CDC42BPA 0.53 7.23 0.37 3.32e-12 Neutrophil percentage of white cells; LUSC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg15595755 chr5:1867978 NA 0.46 8.49 0.42 6.64e-16 Cardiovascular disease risk factors; LUSC cis rs73198271 0.562 rs11774860 chr8:8651879 C/T cg01851573 chr8:8652454 MFHAS1 0.59 7.83 0.39 6.33e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17253792 0.822 rs8006705 chr14:56171283 C/T cg01858014 chr14:56050164 KTN1 -0.7 -6.2 -0.32 1.66e-9 Putamen volume; LUSC cis rs367615 0.512 rs414724 chr5:108670421 A/G cg17395555 chr5:108820864 NA 0.55 9.69 0.47 1e-19 Colorectal cancer (SNP x SNP interaction); LUSC cis rs12136530 0.774 rs11590840 chr1:19779673 A/G cg01832549 chr1:19774989 CAPZB -0.3 -5.73 -0.3 2.3e-8 Lead levels in blood; LUSC cis rs12541635 0.966 rs7839239 chr8:107020406 C/T cg10147462 chr8:107024639 NA 0.55 9.93 0.48 1.54e-20 Age of smoking initiation; LUSC cis rs4662945 0.525 rs28625431 chr2:130303333 A/G cg05962382 chr2:130345044 NA -0.36 -6.34 -0.33 7.63e-10 Response to cytidine analogues (gemcitabine); LUSC cis rs28830936 0.934 rs2412641 chr15:42124399 G/A cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.72 -0.3 2.37e-8 Diastolic blood pressure; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg04025307 chr7:1156635 C7orf50 0.54 8.71 0.43 1.45e-16 Longevity;Endometriosis; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.45 -5.72 -0.3 2.38e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -15.09 -0.64 1.3e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs9807841 0.545 rs4804514 chr19:10764203 G/T cg17710535 chr19:10819994 QTRT1 0.41 6.78 0.35 5.45e-11 Inflammatory skin disease; LUSC cis rs3771570 1.000 rs62193175 chr2:242284405 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.86 0.35 3.32e-11 Prostate cancer; LUSC cis rs6494488 0.500 rs72742918 chr15:64852576 T/C cg08069370 chr15:64387884 SNX1 -0.64 -5.74 -0.3 2.17e-8 Coronary artery disease; LUSC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg27297192 chr10:134578999 INPP5A 0.36 6.48 0.33 3.29e-10 Migraine; LUSC trans rs1499614 0.901 rs3936 chr7:66126489 C/T cg10756647 chr7:56101905 PSPH 0.88 8.96 0.44 2.32e-17 Gout; LUSC cis rs9341808 0.667 rs2505929 chr6:80834208 A/G cg08355045 chr6:80787529 NA 0.47 8.24 0.41 3.89e-15 Sitting height ratio; LUSC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg14298792 chr15:30685198 CHRFAM7A 0.66 8.43 0.42 1.02e-15 Huntington's disease progression; LUSC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.15e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21659725 chr3:3221576 CRBN -0.57 -7.91 -0.4 3.74e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs61931739 0.517 rs9668303 chr12:34366701 C/T cg06521331 chr12:34319734 NA -0.42 -6.56 -0.34 2.05e-10 Morning vs. evening chronotype; LUSC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg12365402 chr11:9010492 NRIP3 -0.52 -10.14 -0.49 3.05e-21 Hemoglobin concentration; LUSC cis rs1062746 0.502 rs11649601 chr16:87339220 G/C cg02258303 chr16:87377426 FBXO31 -0.54 -8.4 -0.42 1.31e-15 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs72700829 0.593 rs7526955 chr1:150990913 C/G cg11822372 chr1:151115635 SEMA6C -0.7 -6.7 -0.34 8.96e-11 Schizophrenia; LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg03188948 chr7:1209495 NA 0.45 6.88 0.35 2.97e-11 Longevity;Endometriosis; LUSC trans rs61931739 0.635 rs10772122 chr12:33964674 A/C cg26384229 chr12:38710491 ALG10B 0.5 7.59 0.38 3.21e-13 Morning vs. evening chronotype; LUSC cis rs9463078 0.753 rs3778507 chr6:44896803 G/A cg25276700 chr6:44698697 NA -0.3 -6.12 -0.32 2.66e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs931812 0.757 rs13251801 chr8:101902629 A/T cg20993868 chr7:22813445 NA 0.52 9.7 0.47 9.55e-20 Attention deficit hyperactivity disorder and conduct disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09391979 chr2:86333508 PTCD3;POLR1A 0.8 6.57 0.34 1.99e-10 Cognitive performance; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.47 -0.38 6.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6725041 0.547 rs1505353 chr2:213203057 C/A cg16329650 chr2:213403929 ERBB4 -0.42 -6.67 -0.34 1.09e-10 QT interval (ambient particulate matter interaction); LUSC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg24578937 chr1:2090814 PRKCZ 0.46 10.27 0.49 1.08e-21 Height; LUSC cis rs34311866 0.808 rs11248060 chr4:964359 C/T cg07828340 chr4:882639 GAK 0.91 9.31 0.45 1.74e-18 Parkinson's disease; LUSC cis rs7582180 0.764 rs1967341 chr2:100924559 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.44 -0.42 9.64e-16 Intelligence (multi-trait analysis); LUSC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg14019146 chr3:50243930 SLC38A3 0.31 6.84 0.35 3.72e-11 Intelligence (multi-trait analysis); LUSC cis rs5758511 0.773 rs62241023 chr22:42385429 G/A cg00645731 chr22:42541494 CYP2D7P1 0.45 7.15 0.36 5.36e-12 Birth weight; LUSC trans rs62055045 0.528 rs62053065 chr16:71557806 G/A cg21834679 chr15:96891026 NA -0.4 -6.14 -0.32 2.31e-9 Schizophrenia; LUSC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg05082376 chr22:42548792 NA -0.45 -7.22 -0.37 3.54e-12 Schizophrenia; LUSC cis rs7223966 1.000 rs9912904 chr17:61763534 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.74 0.35 6.99e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14240646 chr10:27532245 ACBD5 -0.65 -7.75 -0.39 1.15e-13 Breast cancer; LUSC cis rs2639990 1.000 rs655156 chr18:72898181 T/C cg11568697 chr18:72916393 ZADH2 0.57 6.58 0.34 1.79e-10 Vascular endothelial growth factor levels; LUSC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC cis rs9837602 1.000 rs13069311 chr3:99801628 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.91 -0.31 8.58e-9 Breast cancer; LUSC cis rs17604090 0.878 rs4457221 chr7:29701774 C/T cg19413766 chr7:29689036 LOC646762 -0.64 -7.7 -0.39 1.5700000000000001e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.68 10.24 0.49 1.4e-21 Lymphocyte counts; LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg12564285 chr5:131593104 PDLIM4 0.46 8.13 0.41 8.7e-15 Acylcarnitine levels; LUSC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg22800045 chr5:56110881 MAP3K1 -0.75 -9.52 -0.46 3.59e-19 Initial pursuit acceleration; LUSC cis rs11158026 0.757 rs7153937 chr14:55470875 A/G cg04306507 chr14:55594613 LGALS3 0.37 7.31 0.37 1.99e-12 Parkinson's disease; LUSC cis rs5769765 1.000 rs768619 chr22:50287266 C/T cg02269571 chr22:50332266 NA -0.55 -8.22 -0.41 4.59e-15 Schizophrenia; LUSC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg08219700 chr8:58056026 NA 0.43 5.68 0.3 2.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs7827545 1.000 rs6992097 chr8:135565844 G/A cg17885191 chr8:135476712 NA 0.56 8.35 0.42 1.87e-15 Hypertension (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.9 0.48 2e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs977987 0.806 rs34021527 chr16:75474090 A/G cg03315344 chr16:75512273 CHST6 0.49 9.38 0.46 1.03e-18 Dupuytren's disease; LUSC cis rs4243830 1.000 rs12027598 chr1:6600804 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.96 9.12 0.45 7.44e-18 Body mass index; LUSC cis rs6120849 0.754 rs6088686 chr20:33623437 C/T cg24642439 chr20:33292090 TP53INP2 0.62 6.78 0.35 5.4e-11 Protein C levels; LUSC cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg20135002 chr11:47629003 NA 0.48 7.54 0.38 4.4e-13 Subjective well-being; LUSC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 12.48 0.56 1.3e-29 Platelet count; LUSC cis rs2370759 1.000 rs7910776 chr10:32639093 C/T cg01819863 chr10:32635814 EPC1 0.91 10.71 0.51 3.27e-23 Sexual dysfunction (female); LUSC cis rs886126 0.853 rs4766558 chr12:111664061 T/G cg10833066 chr12:111807467 FAM109A 0.41 6.46 0.33 3.65e-10 Coronary heart disease; LUSC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg03289416 chr15:75166202 SCAMP2 0.45 6.87 0.35 3.19e-11 Breast cancer; LUSC cis rs2404602 0.735 rs2436996 chr15:76817420 C/T cg23625390 chr15:77176239 SCAPER -0.62 -9.3 -0.45 1.95e-18 Blood metabolite levels; LUSC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg23283495 chr1:209979779 IRF6 0.64 9.28 0.45 2.13e-18 Cleft lip with or without cleft palate; LUSC cis rs2835872 0.759 rs2835898 chr21:39071781 T/C cg20424643 chr21:39039972 KCNJ6 0.4 6.05 0.31 3.88e-9 Electroencephalographic traits in alcoholism; LUSC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg11764359 chr7:65958608 NA -0.54 -7.11 -0.36 7.23e-12 Aortic root size; LUSC cis rs6967385 0.560 rs7790370 chr7:12353523 G/C cg10578991 chr7:12443926 VWDE 0.39 5.84 0.3 1.25e-8 Response to taxane treatment (placlitaxel); LUSC cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg23711669 chr6:146136114 FBXO30 0.74 12.95 0.58 2.36e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs7712401 0.580 rs4288111 chr5:122388182 A/G cg19077854 chr5:122220652 SNX24 -0.3 -6.41 -0.33 5.03e-10 Mean platelet volume; LUSC cis rs6754311 0.731 rs7579771 chr2:136580260 T/A cg25344623 chr2:136566232 LCT -0.38 -5.65 -0.3 3.49e-8 Mosquito bite size; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02018176 chr4:1364513 KIAA1530 0.72 13.9 0.61 5.85e-35 Longevity; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03828939 chr16:2525452 TBC1D24 -0.48 -6.65 -0.34 1.21e-10 Hepatitis; LUSC cis rs708547 0.647 rs1626594 chr4:57878254 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.64 0.39 2.31e-13 Response to bleomycin (chromatid breaks); LUSC cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.7 0.34 8.99e-11 Rheumatoid arthritis; LUSC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg18876405 chr7:65276391 NA 0.54 8.24 0.41 3.93e-15 Aortic root size; LUSC trans rs12709013 0.636 rs4538000 chr16:58778410 A/C cg19313373 chr1:162694184 DDR2 -0.35 -5.95 -0.31 6.74e-9 Blood metabolite ratios; LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.79 -0.35 5.15e-11 Menopause (age at onset); LUSC cis rs6469656 1.000 rs35905748 chr8:117755248 A/G cg24004040 chr8:117650383 NA -0.43 -6.16 -0.32 2.15e-9 Colorectal cancer; LUSC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg18402987 chr7:1209562 NA 0.51 5.66 0.3 3.31e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 20.09 0.74 2.07e-59 Prudent dietary pattern; LUSC cis rs694739 0.628 rs538147 chr11:64129722 G/A cg26898376 chr11:64110657 CCDC88B 0.33 6.21 0.32 1.6e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg01570182 chr17:44337453 NA 0.69 10.43 0.5 3.15e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg02807482 chr3:125708958 NA -0.53 -6.62 -0.34 1.42e-10 Blood pressure (smoking interaction); LUSC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -8.41 -0.42 1.24e-15 Schizophrenia; LUSC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg15147215 chr3:52552868 STAB1 -0.29 -5.76 -0.3 1.93e-8 Electroencephalogram traits; LUSC cis rs453301 0.686 rs3895823 chr8:8873646 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.61 -0.38 2.74e-13 Joint mobility (Beighton score); LUSC cis rs9788721 0.934 rs1317286 chr15:78896129 A/G cg06917634 chr15:78832804 PSMA4 -0.43 -5.84 -0.3 1.24e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.07 0.4 1.29e-14 Breast cancer; LUSC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg06637938 chr14:75390232 RPS6KL1 -0.53 -8.59 -0.43 3.48e-16 Height; LUSC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg13683864 chr3:40499215 RPL14 -1.14 -21.07 -0.76 2.71e-63 Renal cell carcinoma; LUSC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg19717773 chr7:2847554 GNA12 -0.37 -5.88 -0.31 9.82e-9 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15807973 chr10:88281572 WAPAL -0.44 -6.71 -0.34 8.17e-11 Electrocardiographic conduction measures; LUSC cis rs7072216 0.806 rs9804285 chr10:100169472 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.76 -0.43 1.02e-16 Metabolite levels; LUSC cis rs11190604 1.000 rs2495742 chr10:102331364 C/T cg16342193 chr10:102329863 NA -0.37 -6.54 -0.34 2.27e-10 Palmitoleic acid (16:1n-7) levels; LUSC trans rs3733585 0.648 rs13103497 chr4:9979262 A/G cg26043149 chr18:55253948 FECH 0.47 7.26 0.37 2.67e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs28595532 0.582 rs71608361 chr4:119224081 T/C cg21605333 chr4:119757512 SEC24D 0.77 6.47 0.33 3.59e-10 Cannabis dependence symptom count; LUSC cis rs7923609 0.905 rs7092784 chr10:65214749 C/T cg01631684 chr10:65280961 REEP3 -0.41 -6.24 -0.32 1.31e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9372253 0.967 rs1055301 chr6:110713042 A/G cg01119278 chr6:110721349 DDO -0.45 -7.96 -0.4 2.62e-14 Platelet distribution width; LUSC cis rs72781680 0.948 rs113530757 chr2:24142500 G/A cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs6750047 0.719 rs336035 chr2:38261467 A/G cg07380506 chr2:38303506 CYP1B1 -0.44 -5.92 -0.31 8.15e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs6464929 0.956 rs3779039 chr7:148710576 C/T cg23583168 chr7:148888333 NA 0.47 6.0 0.31 5.26e-9 Pediatric bone mineral content (hip); LUSC cis rs7177699 0.557 rs4380028 chr15:79111093 C/T cg00540400 chr15:79124168 NA -0.48 -8.43 -0.42 1.04e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9807989 0.507 rs1420097 chr2:103009354 C/G cg03938978 chr2:103052716 IL18RAP -0.33 -6.07 -0.32 3.42e-9 Asthma; LUSC cis rs9796 0.717 rs2947494 chr15:41375741 C/T cg18705301 chr15:41695430 NDUFAF1 -0.47 -8.27 -0.41 3.13e-15 Menopause (age at onset); LUSC cis rs75229567 0.618 rs11177848 chr12:70180892 A/G cg10114359 chr12:70132523 RAB3IP 1.43 12.91 0.58 3.43e-31 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg04398451 chr17:18023971 MYO15A 0.57 9.53 0.46 3.41e-19 Total body bone mineral density; LUSC cis rs4654899 0.931 rs1152998 chr1:21124290 C/T cg01072550 chr1:21505969 NA -0.52 -7.88 -0.4 4.59e-14 Superior frontal gyrus grey matter volume; LUSC cis rs13217239 0.646 rs2142685 chr6:27054497 C/T cg12292205 chr6:26970375 C6orf41 -0.5 -8.19 -0.41 5.49e-15 Schizophrenia; LUSC cis rs7246657 0.943 rs1015848 chr19:37945274 A/C cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.08e-17 Prudent dietary pattern; LUSC cis rs1358748 0.522 rs4655671 chr1:67550763 C/T cg02640540 chr1:67518911 SLC35D1 0.62 6.4 0.33 5.25e-10 Tuberculosis; LUSC cis rs35079168 0.701 rs3132296 chr9:137302631 C/T cg24164254 chr9:137329341 RXRA -0.37 -5.97 -0.31 5.98e-9 Intelligence; LUSC cis rs3916 0.911 rs34673751 chr12:121171891 G/A cg27246729 chr12:121163418 ACADS 0.46 6.7 0.34 8.84e-11 Urinary metabolites (H-NMR features); LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg03790207 chr6:42947109 PEX6 0.4 5.81 0.3 1.42e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg08999081 chr20:33150536 PIGU -0.53 -10.53 -0.5 1.4e-22 Glomerular filtration rate (creatinine); LUSC trans rs10511400 0.618 rs2874023 chr3:119919544 T/C cg02809009 chr19:50354510 PTOV1 -0.7 -6.22 -0.32 1.44e-9 Economic and political preferences (feminism/equality); LUSC cis rs2880765 0.835 rs6497206 chr15:86029225 A/G cg13263323 chr15:86062960 AKAP13 -0.35 -5.75 -0.3 2.02e-8 Coronary artery disease; LUSC cis rs7177699 0.526 rs7166764 chr15:79123509 T/G cg15571903 chr15:79123663 NA 0.34 6.31 0.33 8.74e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9287719 0.837 rs4233883 chr2:10755596 A/G cg03983476 chr2:10830698 NOL10 -0.37 -5.67 -0.3 3.05e-8 Prostate cancer; LUSC cis rs7586879 0.639 rs7567997 chr2:25096952 A/G cg04586622 chr2:25135609 ADCY3 0.38 8.2 0.41 5.21e-15 Body mass index; LUSC cis rs9916302 0.752 rs11078895 chr17:37401051 A/G cg07936489 chr17:37558343 FBXL20 -0.76 -10.21 -0.49 1.76e-21 Glomerular filtration rate (creatinine); LUSC trans rs67340775 0.748 rs13212651 chr6:27806985 A/G cg06606381 chr12:133084897 FBRSL1 -1.0 -8.84 -0.44 5.76e-17 Lung cancer in ever smokers; LUSC cis rs735396 0.731 rs1182933 chr12:121454622 C/T cg02403541 chr12:121454288 C12orf43 0.7 10.2 0.49 1.88e-21 N-glycan levels; LUSC cis rs4805272 0.512 rs765484 chr19:29344663 A/G cg03161606 chr19:29218774 NA 0.51 5.96 0.31 6.3e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg16145915 chr7:1198662 ZFAND2A -0.47 -8.73 -0.43 1.21e-16 Longevity;Endometriosis; LUSC trans rs6089829 0.962 rs6089824 chr20:61659207 A/G cg13615516 chr5:77269221 NA 0.4 6.56 0.34 2.02e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg09835421 chr16:68378352 PRMT7 -0.55 -6.22 -0.32 1.45e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.53 0.34 2.48e-10 Obesity-related traits; LUSC cis rs8060686 0.545 rs10500543 chr16:68281311 T/C cg27539214 chr16:67997921 SLC12A4 -0.59 -7.0 -0.36 1.39e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs11155671 0.530 rs9383577 chr6:150207195 C/T cg09699651 chr6:150184138 LRP11 0.45 7.15 0.36 5.64e-12 Testicular germ cell tumor; LUSC cis rs1371867 0.875 rs1612773 chr8:101337818 G/C cg00191853 chr8:101177733 SPAG1 -0.35 -5.71 -0.3 2.43e-8 Atrioventricular conduction; LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg01879757 chr17:41196368 BRCA1 -0.45 -6.83 -0.35 3.97e-11 Menopause (age at onset); LUSC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg13298116 chr11:62369859 EML3;MTA2 -0.58 -9.76 -0.47 5.93e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 2.04e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg13939156 chr17:80058883 NA -0.33 -6.6 -0.34 1.62e-10 Life satisfaction; LUSC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg09021430 chr5:549028 NA -0.57 -8.38 -0.42 1.51e-15 Obesity-related traits; LUSC cis rs6565180 1.000 rs12930787 chr16:30381303 C/G cg17640201 chr16:30407289 ZNF48 -0.89 -15.01 -0.63 2.88e-39 Tonsillectomy; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg05157912 chr14:75894395 JDP2 -0.49 -6.75 -0.35 6.38e-11 Cognitive function;Information processing speed; LUSC cis rs3213545 0.700 rs2260445 chr12:121468863 C/A cg02403541 chr12:121454288 C12orf43 0.56 8.66 0.43 2.06e-16 Subjective well-being;Cardiovascular disease risk factors; LUSC cis rs11098499 0.954 rs6847248 chr4:120225955 A/G cg09307838 chr4:120376055 NA 0.77 10.65 0.5 5.38e-23 Corneal astigmatism; LUSC cis rs9323205 0.634 rs61985124 chr14:51712633 T/C cg23942311 chr14:51606299 NA -0.38 -6.88 -0.35 2.9e-11 Cancer; LUSC cis rs6087990 0.899 rs4911107 chr20:31374991 G/A cg13636640 chr20:31349939 DNMT3B 0.95 20.04 0.74 3.35e-59 Ulcerative colitis; LUSC cis rs8141529 0.956 rs132539 chr22:29304253 C/T cg02153584 chr22:29168773 CCDC117 0.52 7.48 0.38 6.55e-13 Lymphocyte counts; LUSC cis rs5770917 1.000 rs2269385 chr22:51010939 G/A cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.7 -0.3 2.69e-8 Narcolepsy; LUSC cis rs1775715 0.870 rs1615256 chr10:32254101 T/C cg18675610 chr10:32216311 ARHGAP12 0.29 6.06 0.31 3.63e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs79149102 0.579 rs73438569 chr15:75354486 T/A cg09165964 chr15:75287851 SCAMP5 -0.87 -7.72 -0.39 1.36e-13 Lung cancer; LUSC cis rs12286929 0.831 rs2507909 chr11:115010867 C/T cg04055981 chr11:115044050 NA 0.36 6.02 0.31 4.52e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg19747945 chr6:42946146 PEX6 -0.34 -5.68 -0.3 2.94e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg18357526 chr6:26021779 HIST1H4A 0.42 6.8 0.35 4.97e-11 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.519 rs11732209 chr4:98801643 A/G cg03676636 chr4:99064102 C4orf37 0.3 5.97 0.31 6.04e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs17095355 1.000 rs17126931 chr10:111754633 T/C cg00817464 chr10:111662876 XPNPEP1 -0.66 -7.58 -0.38 3.36e-13 Biliary atresia; LUSC cis rs708547 0.830 rs1713983 chr4:57883084 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -6.81 -0.35 4.6e-11 Response to bleomycin (chromatid breaks); LUSC cis rs4363385 0.574 rs4041402 chr1:152947397 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.76 -0.3 1.91e-8 Inflammatory skin disease; LUSC cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg12573674 chr2:1569213 NA -0.55 -6.16 -0.32 2.15e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs4589502 1.000 rs79390908 chr15:67130924 C/T cg12317470 chr15:67143691 NA 0.67 6.01 0.31 4.76e-9 Lung cancer (smoking interaction); LUSC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.49 0.46 4.63e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -14.97 -0.63 3.94e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs28655083 0.529 rs4550465 chr16:77104785 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.44 7.11 0.36 7.24e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9329221 0.870 rs11777976 chr8:10255402 A/G cg21775007 chr8:11205619 TDH -0.57 -8.39 -0.42 1.39e-15 Neuroticism; LUSC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg14664628 chr15:75095509 CSK -0.49 -7.01 -0.36 1.32e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC trans rs561341 1.000 rs473356 chr17:30321762 G/C cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs11030122 0.702 rs67300156 chr11:3953949 C/T cg18678763 chr11:4115507 RRM1 -0.45 -5.82 -0.3 1.34e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs2282300 0.667 rs10734405 chr11:30273750 T/C cg25418670 chr11:30344373 C11orf46 0.64 9.19 0.45 4.18e-18 Morning vs. evening chronotype; LUSC cis rs2742234 0.915 rs2742233 chr10:43610558 C/T cg15436174 chr10:43711423 RASGEF1A -0.37 -6.52 -0.34 2.6e-10 Hirschsprung disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24334803 chr1:249132834 ZNF672 0.42 6.03 0.31 4.27e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7904368 0.754 rs12246217 chr10:16853349 G/C cg23933602 chr10:16859644 RSU1 0.59 6.92 0.35 2.31e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs1595825 0.891 rs17520121 chr2:198898718 T/G cg10547527 chr2:198650123 BOLL -0.52 -6.15 -0.32 2.27e-9 Ulcerative colitis; LUSC cis rs6696846 0.791 rs11240352 chr1:205051711 C/G cg00857998 chr1:205179979 DSTYK -0.61 -9.57 -0.46 2.46e-19 Red blood cell count; LUSC cis rs7937682 1.000 rs11608149 chr11:111535102 G/A cg09085632 chr11:111637200 PPP2R1B 1.08 16.37 0.67 1.22e-44 Primary sclerosing cholangitis; LUSC cis rs354225 1.000 rs354225 chr2:54923766 G/A cg26097391 chr2:54893211 SPTBN1 0.38 6.37 0.33 6.21e-10 Schizophrenia; LUSC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg06494592 chr3:125709126 NA -0.5 -5.77 -0.3 1.86e-8 Blood pressure (smoking interaction); LUSC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg19046167 chr17:80928561 B3GNTL1 -0.43 -6.18 -0.32 1.86e-9 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22180410 chr4:187646446 FAT1 0.37 5.98 0.31 5.81e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7091068 0.550 rs7901909 chr10:95492508 C/T cg20715218 chr10:95462985 C10orf4 0.64 8.72 0.43 1.33e-16 Urinary tract infection frequency; LUSC cis rs13088645 0.532 rs12695612 chr3:134161824 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.45 5.89 0.31 9.29e-9 Coronary artery disease; LUSC cis rs9473147 0.543 rs9381578 chr6:47556634 C/T cg12968598 chr6:47444699 CD2AP 0.52 7.93 0.4 3.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs11098499 0.821 rs3775852 chr4:120454556 A/G cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg23625390 chr15:77176239 SCAPER 0.46 7.0 0.36 1.44e-11 Blood metabolite levels; LUSC cis rs11676348 0.774 rs57545959 chr2:219047718 A/G cg00012203 chr2:219082015 ARPC2 0.58 9.47 0.46 5.32e-19 Ulcerative colitis; LUSC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg06742321 chr12:123595122 PITPNM2 0.4 6.13 0.32 2.42e-9 Platelet count; LUSC cis rs6087990 0.735 rs4911260 chr20:31376490 T/C cg13636640 chr20:31349939 DNMT3B 0.9 18.21 0.71 5.77e-52 Ulcerative colitis; LUSC cis rs11031096 0.503 rs67065286 chr11:4105273 A/C cg18678763 chr11:4115507 RRM1 -0.5 -6.61 -0.34 1.5e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs734999 0.566 rs4648563 chr1:2536002 C/G cg18932078 chr1:2524107 MMEL1 0.32 7.04 0.36 1.13e-11 Ulcerative colitis; LUSC cis rs6736093 0.933 rs6754526 chr2:112729669 A/G cg12686935 chr2:112915763 FBLN7 -0.37 -5.96 -0.31 6.32e-9 Coronary artery disease; LUSC cis rs11098499 0.863 rs10004484 chr4:120442428 C/T cg09307838 chr4:120376055 NA 0.73 10.24 0.49 1.39e-21 Corneal astigmatism; LUSC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.29 -5.81 -0.3 1.43e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs11935423 0.778 rs1503778 chr4:100490688 G/A cg02164153 chr5:172068145 NEURL1B -0.47 -6.07 -0.32 3.51e-9 Gut microbiome composition (summer); LUSC cis rs16976116 0.901 rs28708989 chr15:55498934 C/T cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7581030 0.517 rs17743415 chr2:71562503 T/C cg06465196 chr4:154387603 KIAA0922 0.42 5.95 0.31 6.95e-9 Testicular germ cell tumor; LUSC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs10186029 0.648 rs13022006 chr2:213940309 A/C cg08319019 chr2:214017104 IKZF2 0.6 8.9 0.44 3.71e-17 Systemic sclerosis; LUSC cis rs12545109 0.800 rs2670054 chr8:57421616 C/T cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18373552 chr10:76871314 SAMD8 -0.42 -6.32 -0.33 8.45e-10 Electrocardiographic conduction measures; LUSC cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg23711669 chr6:146136114 FBXO30 0.93 17.83 0.7 1.93e-50 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.513 rs4931760 chr12:33898361 T/C cg26384229 chr12:38710491 ALG10B 0.57 8.85 0.44 5.35e-17 Morning vs. evening chronotype; LUSC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.6 0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.79 0.7 2.73e-50 Chronic sinus infection; LUSC cis rs9457247 0.565 rs2038580 chr6:167456490 A/T cg25258033 chr6:167368657 RNASET2 0.42 6.37 0.33 6.31e-10 Crohn's disease; LUSC cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg06784218 chr1:46089804 CCDC17 0.55 11.13 0.52 1.06e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg03233332 chr7:66118400 NA -0.42 -6.08 -0.32 3.3e-9 Aortic root size; LUSC cis rs2070488 0.775 rs4679066 chr3:38568527 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.67 -11.86 -0.54 2.63e-27 Electrocardiographic conduction measures; LUSC cis rs757110 0.770 rs1557765 chr11:17403639 T/C cg15432903 chr11:17409602 KCNJ11 0.62 11.27 0.52 3.5e-25 Type 2 diabetes; LUSC cis rs3781663 0.526 rs7936612 chr11:70019182 A/G cg24276624 chr11:69982941 ANO1 -0.39 -5.94 -0.31 7.19e-9 Survival in rectal cancer; LUSC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg18681998 chr4:17616180 MED28 0.91 17.58 0.69 1.92e-49 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11711311 0.910 rs62265549 chr3:113396234 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.22 0.32 1.45e-9 IgG glycosylation; LUSC cis rs2346177 0.519 rs1597040 chr2:46673903 C/T cg02822958 chr2:46747628 ATP6V1E2 0.48 8.42 0.42 1.1e-15 HDL cholesterol; LUSC trans rs433755 1.000 rs433755 chr5:9474946 A/C cg05169988 chr15:99204912 IGF1R -0.26 -6.17 -0.32 1.94e-9 Obesity-related traits; LUSC cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg12935359 chr14:103987150 CKB 0.65 10.68 0.5 4.05e-23 Intelligence (multi-trait analysis); LUSC cis rs10746514 0.833 rs11122428 chr1:232261417 A/G cg09506761 chr1:232265262 NA -0.56 -9.56 -0.46 2.57e-19 Response to statin therapy; LUSC trans rs804280 0.542 rs34117651 chr8:11791617 G/C cg14343924 chr8:8086146 FLJ10661 0.43 5.97 0.31 6.11e-9 Myopia (pathological); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg27288268 chr19:14063180 PODNL1;DCAF15 0.67 5.97 0.31 6.18e-9 Cognitive performance; LUSC cis rs4423214 0.918 rs11233789 chr11:71181085 A/G cg05163923 chr11:71159392 DHCR7 0.78 11.53 0.53 4e-26 Vitamin D levels; LUSC cis rs6582630 0.538 rs12305104 chr12:38336353 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.46 -0.38 7.3e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg16423285 chr20:60520624 NA -0.46 -5.86 -0.31 1.12e-8 Body mass index; LUSC cis rs11166629 1.000 rs7003870 chr8:135616586 A/G cg21672855 chr8:135614777 ZFAT 0.39 6.03 0.31 4.31e-9 Smoking quantity; LUSC cis rs7208859 0.623 rs34756112 chr17:29113016 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs12080794 1.000 rs12239200 chr1:9155963 A/T cg11315153 chr6:62996299 KHDRBS2 -0.52 -6.16 -0.32 2.13e-9 Response to antidepressant treatment (citalopram); LUSC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg20891283 chr12:69753455 YEATS4 0.66 10.45 0.5 2.68e-22 Blood protein levels; LUSC cis rs9868809 0.764 rs2633958 chr3:48635432 A/G cg00383909 chr3:49044727 WDR6 -0.85 -7.51 -0.38 5.39e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg02380750 chr20:61661411 NA 0.34 5.92 0.31 8.1e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs8014204 0.816 rs10144023 chr14:75291531 T/C cg06637938 chr14:75390232 RPS6KL1 0.51 8.16 0.41 7.1e-15 Caffeine consumption; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02386183 chr20:13619553 TASP1 0.39 6.36 0.33 6.81e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7759001 0.857 rs6912091 chr6:27354852 C/G cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC trans rs6967330 0.584 rs73195679 chr7:105677321 C/A cg07911171 chr1:7340656 CAMTA1 0.43 6.3 0.33 9.25e-10 Asthma (childhood onset); LUSC cis rs932287 0.666 rs10840161 chr11:9053824 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.47 9.07 0.44 1.03e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.780 rs2500413 chr20:25241155 T/C cg08601574 chr20:25228251 PYGB 0.48 7.42 0.38 9.92e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2439831 0.867 rs935901 chr15:43651256 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.91 8.46 0.42 8.77e-16 Lung cancer in ever smokers; LUSC trans rs2739330 0.828 rs2154593 chr22:24252085 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.55 -8.54 -0.42 4.78e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg18876405 chr7:65276391 NA 0.56 8.78 0.43 8.88e-17 Aortic root size; LUSC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg20135002 chr11:47629003 NA -0.49 -7.69 -0.39 1.65e-13 Subjective well-being; LUSC trans rs8072100 0.967 rs11871606 chr17:45732774 G/T cg03886242 chr7:26192032 NFE2L3 0.39 6.51 0.34 2.68e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7103648 0.695 rs7933019 chr11:47509137 G/C cg20307385 chr11:47447363 PSMC3 0.86 13.71 0.6 2.99e-34 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs9399135 0.967 rs9399129 chr6:135285148 C/A cg24558204 chr6:135376177 HBS1L 0.6 9.2 0.45 4.04e-18 Red blood cell count; LUSC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg25258033 chr6:167368657 RNASET2 0.45 7.65 0.39 2.1e-13 Crohn's disease; LUSC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg06221963 chr1:154839813 KCNN3 -0.63 -14.63 -0.63 8.25e-38 Prostate cancer; LUSC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg21972741 chr5:435613 AHRR 0.33 6.26 0.32 1.18e-9 Cystic fibrosis severity; LUSC cis rs6977660 1.000 rs34367208 chr7:19818811 T/G cg07541023 chr7:19748670 TWISTNB 0.51 5.82 0.3 1.37e-8 Thyroid stimulating hormone; LUSC cis rs4969178 0.965 rs3817294 chr17:76396963 A/G cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg13072238 chr3:49761600 GMPPB -0.67 -8.32 -0.41 2.34e-15 Menarche (age at onset); LUSC cis rs7527798 0.571 rs12045913 chr1:207844625 A/G cg09232269 chr1:207846808 CR1L -0.28 -6.0 -0.31 5.05e-9 Erythrocyte sedimentation rate; LUSC cis rs7804356 1.000 rs3801844 chr7:26829759 C/T cg03456212 chr7:26904342 SKAP2 0.52 6.21 0.32 1.53e-9 Type 1 diabetes; LUSC cis rs1729951 0.575 rs168635 chr3:136699078 A/G cg21827317 chr3:136751795 NA 0.37 6.67 0.34 1.06e-10 Neuroticism; LUSC cis rs385076 0.503 rs212702 chr2:32444250 A/G cg02381751 chr2:32503542 YIPF4 0.54 6.88 0.35 3.01e-11 Interleukin-18 levels; LUSC cis rs9462027 0.628 rs1125340 chr6:34786408 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.74 -0.3 2.13e-8 Systemic lupus erythematosus; LUSC cis rs6489882 0.807 rs1859333 chr12:113370966 T/C cg20102336 chr12:113376681 OAS3 -0.42 -6.17 -0.32 1.98e-9 Chronic lymphocytic leukemia; LUSC cis rs11051970 0.879 rs73081911 chr12:32539124 C/G cg24626660 chr12:32551988 NA 0.38 6.11 0.32 2.79e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1670533 1.000 rs6839931 chr4:1053172 A/G cg02018176 chr4:1364513 KIAA1530 0.43 5.91 0.31 8.37e-9 Recombination rate (females); LUSC cis rs983392 0.755 rs1441586 chr11:59856028 T/C cg20284999 chr11:59952153 MS4A6A -0.33 -5.68 -0.3 2.98e-8 Alzheimer's disease (late onset); LUSC cis rs10887741 0.966 rs2077695 chr10:89435483 T/C cg24243914 chr10:89418206 PAPSS2 0.32 5.86 0.31 1.09e-8 Exercise (leisure time); LUSC cis rs3020736 0.500 rs6002623 chr22:42513761 G/A cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs10752881 1.000 rs10752886 chr1:182987248 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg13607699 chr17:42295918 UBTF 0.48 7.45 0.38 8.04e-13 Total body bone mineral density; LUSC cis rs10207060 0.500 rs4365487 chr2:240706803 T/C cg20333904 chr2:240724165 NA -0.35 -6.1 -0.32 2.94e-9 Obesity-related traits; LUSC cis rs2836633 0.965 rs2836621 chr21:40054149 C/T cg05519781 chr21:40033154 ERG 0.7 11.63 0.54 1.83e-26 Coronary artery disease; LUSC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg00012203 chr2:219082015 ARPC2 0.7 11.64 0.54 1.61e-26 Colorectal cancer; LUSC cis rs2239815 0.515 rs9625595 chr22:29238913 C/T cg02153584 chr22:29168773 CCDC117 0.55 6.41 0.33 4.84e-10 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs11098499 0.662 rs13108589 chr4:120268102 G/C cg24375607 chr4:120327624 NA 0.77 12.11 0.55 3.24e-28 Corneal astigmatism; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02528468 chr3:182510901 ATP11B 0.39 5.96 0.31 6.29e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg04352962 chr1:209979756 IRF6 -0.4 -5.98 -0.31 5.69e-9 Monobrow; LUSC cis rs2439831 1.000 rs690436 chr15:43761205 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs7192380 0.964 rs55780735 chr16:69740374 A/G cg00738113 chr16:70207722 CLEC18C 0.27 5.92 0.31 8.13e-9 Sjögren's syndrome; LUSC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.04 -0.31 4.18e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg05347473 chr6:146136440 FBXO30 0.39 6.49 0.33 3.16e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg03806693 chr22:41940476 POLR3H -0.93 -13.27 -0.59 1.43e-32 Vitiligo; LUSC trans rs1994135 0.630 rs11052760 chr12:33724949 A/T cg13010199 chr12:38710504 ALG10B 0.55 7.56 0.38 3.86e-13 Resting heart rate; LUSC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg27572855 chr1:25598939 RHD 0.44 7.84 0.39 6.26e-14 Plateletcrit;Mean corpuscular volume; LUSC cis rs1670533 1.000 rs11735663 chr4:1051845 C/T cg19318889 chr4:1322082 MAEA 0.43 5.65 0.3 3.37e-8 Recombination rate (females); LUSC cis rs28374715 0.532 rs1899 chr15:41689232 C/T cg18705301 chr15:41695430 NDUFAF1 -1.04 -21.96 -0.77 8.49e-67 Ulcerative colitis; LUSC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg11764359 chr7:65958608 NA -0.63 -9.66 -0.47 1.24e-19 Aortic root size; LUSC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.11 0.45 8.02e-18 Tonsillectomy; LUSC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs7584330 0.554 rs13395743 chr2:238437554 C/T cg16989719 chr2:238392110 NA -0.42 -5.81 -0.3 1.47e-8 Prostate cancer; LUSC cis rs1823874 0.653 rs12902823 chr15:100352218 G/A cg16400843 chr15:100339927 C15orf51 0.34 6.7 0.34 9.1e-11 IgG glycosylation; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04290376 chr6:26056765 HIST1H1C 0.44 5.95 0.31 6.82e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs616402 0.527 rs11121581 chr1:10577740 A/G cg17425144 chr1:10567563 PEX14 0.65 13.39 0.59 5.04e-33 Breast size; LUSC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg06740227 chr12:86229804 RASSF9 0.45 7.15 0.36 5.35e-12 Major depressive disorder; LUSC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.47 -0.46 5.25e-19 Gut microbiome composition (summer); LUSC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg07212818 chr11:638076 DRD4 -0.46 -7.29 -0.37 2.19e-12 Systemic lupus erythematosus; LUSC cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.82 -0.3 1.41e-8 Bipolar disorder; LUSC cis rs7923609 0.967 rs10761729 chr10:64995604 G/C cg01631684 chr10:65280961 REEP3 -0.4 -6.26 -0.32 1.19e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg00343986 chr7:65444356 GUSB -0.42 -6.33 -0.33 8.09e-10 Aortic root size; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg11494091 chr17:61959527 GH2 0.63 13.42 0.59 3.75e-33 Prudent dietary pattern; LUSC cis rs2479724 0.636 rs41273794 chr6:41755708 C/T cg17623882 chr6:41773611 USP49 0.5 6.51 0.34 2.81e-10 Menarche (age at onset); LUSC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21659725 chr3:3221576 CRBN -0.89 -18.69 -0.71 7.45e-54 Intelligence (multi-trait analysis); LUSC trans rs984440 0.524 rs10111139 chr8:139084283 C/T cg03334052 chr1:168888044 NA -0.38 -6.25 -0.32 1.24e-9 Obesity-related traits; LUSC cis rs3820068 0.581 rs68052904 chr1:15916714 T/C cg13390004 chr1:15929781 NA 0.42 7.0 0.36 1.44e-11 Systolic blood pressure; LUSC cis rs354225 0.544 rs3287 chr2:54807657 T/C cg26097391 chr2:54893211 SPTBN1 0.42 6.31 0.33 8.77e-10 Schizophrenia; LUSC cis rs4356932 1.000 rs4859598 chr4:76959828 C/T cg00809888 chr4:76862425 NAAA 0.34 5.75 0.3 1.98e-8 Blood protein levels; LUSC cis rs11785400 0.793 rs4467920 chr8:143736846 C/T cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg16447950 chr5:562315 NA -0.55 -6.69 -0.34 9.28e-11 Obesity-related traits; LUSC cis rs4595586 0.679 rs7131749 chr12:39405462 A/G cg26384229 chr12:38710491 ALG10B -0.47 -6.65 -0.34 1.19e-10 Morning vs. evening chronotype; LUSC trans rs877282 0.583 rs10904564 chr10:819459 C/G cg22713356 chr15:30763199 NA 0.74 9.71 0.47 8.71e-20 Uric acid levels; LUSC cis rs3125734 0.719 rs4529854 chr10:64043975 C/T cg09941381 chr10:64027924 RTKN2 -0.35 -6.28 -0.32 1.08e-9 Rheumatoid arthritis; LUSC cis rs28735056 0.591 rs62101204 chr18:77712832 G/A cg20368463 chr18:77673604 PQLC1 0.61 9.47 0.46 5.4e-19 Schizophrenia; LUSC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg02117656 chr17:79614917 TSPAN10 0.3 5.67 0.3 3.16e-8 Eye color traits; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg25428929 chr2:242606353 ATG4B -0.41 -6.23 -0.32 1.43e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs752010 0.806 rs4457567 chr1:42091407 C/T cg06885757 chr1:42089581 HIVEP3 0.49 10.05 0.48 6.05e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg01483505 chr11:975446 AP2A2 0.4 5.76 0.3 1.92e-8 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.58 0.38 3.39e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg15557168 chr22:42548783 NA 0.47 7.33 0.37 1.76e-12 Schizophrenia; LUSC trans rs6089829 0.962 rs4586690 chr20:61658595 G/T cg23505145 chr19:12996616 KLF1 0.64 10.29 0.49 9.57e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg07636037 chr3:49044803 WDR6 0.43 6.26 0.32 1.21e-9 Resting heart rate; LUSC cis rs4356932 1.000 rs13130221 chr4:76955617 G/A cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs7592578 0.664 rs10931461 chr2:191405280 T/A cg10560079 chr2:191398806 TMEM194B 0.74 9.08 0.45 9.44e-18 Diastolic blood pressure; LUSC cis rs4851254 0.579 rs78633727 chr2:100669457 T/C cg22139774 chr2:100720529 AFF3 -0.46 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg01579765 chr21:45077557 HSF2BP -0.56 -12.22 -0.56 1.26e-28 Mean corpuscular volume; LUSC cis rs10904908 0.703 rs359287 chr10:17327791 A/T cg01003015 chr10:17271136 VIM 0.42 6.0 0.31 5.12e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs72781680 0.821 rs2176265 chr2:24158638 C/G cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg26513180 chr16:89883248 FANCA -0.53 -7.94 -0.4 3.1e-14 Vitiligo; LUSC cis rs17685 0.753 rs1637044 chr7:75703744 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.7 -0.39 1.58e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs757081 0.667 rs476890 chr11:17209962 A/G cg15432903 chr11:17409602 KCNJ11 -0.38 -5.94 -0.31 7.29e-9 Systolic blood pressure; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg07092213 chr7:1199455 ZFAND2A -0.64 -10.83 -0.51 1.22e-23 Longevity;Endometriosis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19444155 chr15:49338748 SECISBP2L -0.37 -6.03 -0.31 4.26e-9 Triglycerides; LUSC cis rs73206853 0.841 rs7967246 chr12:110756569 G/A cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.3 0.33 9.54e-10 Menopause (age at onset); LUSC cis rs7584330 0.554 rs77194105 chr2:238436463 T/C cg16989719 chr2:238392110 NA -0.49 -6.2 -0.32 1.69e-9 Prostate cancer; LUSC trans rs17685 0.753 rs11972240 chr7:75694079 A/C cg19862616 chr7:65841803 NCRNA00174 1.14 19.91 0.74 1.01e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs701145 0.585 rs1713804 chr3:153799122 A/G cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg00945038 chr17:61921165 SMARCD2 0.53 9.39 0.46 9.85e-19 Prudent dietary pattern; LUSC trans rs9650657 0.571 rs4240673 chr8:10787612 T/C cg15556689 chr8:8085844 FLJ10661 -0.56 -8.42 -0.42 1.16e-15 Neuroticism; LUSC cis rs240764 0.658 rs7746947 chr6:101188708 G/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.51e-10 Neuroticism; LUSC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg13798780 chr7:105162888 PUS7 0.57 6.06 0.31 3.65e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.72 9.01 0.44 1.57e-17 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg00012203 chr2:219082015 ARPC2 0.84 15.65 0.65 8.27e-42 Colorectal cancer; LUSC cis rs8014204 0.839 rs6574197 chr14:75331487 A/G cg06637938 chr14:75390232 RPS6KL1 -0.67 -11.13 -0.52 1.12e-24 Caffeine consumption; LUSC cis rs11608355 0.846 rs4766598 chr12:109853306 A/G cg05360138 chr12:110035743 NA 0.59 7.91 0.4 3.9e-14 Neuroticism; LUSC cis rs4295623 0.585 rs13259242 chr8:11593033 T/G cg21775007 chr8:11205619 TDH -0.5 -7.18 -0.37 4.55e-12 Morning vs. evening chronotype; LUSC cis rs3540 0.597 rs10152221 chr15:91047664 A/G cg04176472 chr15:90893244 GABARAPL3 -0.33 -5.67 -0.3 3.03e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs11098499 0.588 rs6534149 chr4:120559292 T/G cg09307838 chr4:120376055 NA -0.58 -8.71 -0.43 1.42e-16 Corneal astigmatism; LUSC cis rs9393692 0.645 rs11756673 chr6:26323505 A/G cg13736514 chr6:26305472 NA -0.54 -10.51 -0.5 1.6e-22 Educational attainment; LUSC trans rs330071 0.686 rs10087406 chr8:9246598 C/T cg21775007 chr8:11205619 TDH -0.44 -6.26 -0.32 1.19e-9 Acne (severe); LUSC cis rs2414856 0.510 rs72758928 chr15:64657684 C/A cg08069370 chr15:64387884 SNX1 -0.78 -6.58 -0.34 1.84e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs12220238 1.000 rs10824130 chr10:76008931 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.94 0.35 2.08e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs13253111 0.603 rs17058753 chr8:28090914 T/C cg26534493 chr8:28060551 NA 0.4 7.16 0.36 5.05e-12 Childhood body mass index; LUSC cis rs9522267 0.535 rs7326875 chr13:112236231 C/T cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 2.99e-8 Hepatitis; LUSC cis rs1372520 0.748 rs1471484 chr4:90754313 C/T cg15133208 chr4:90757351 SNCA -0.57 -8.5 -0.42 6.46e-16 Neuroticism; LUSC cis rs7786808 0.586 rs7794256 chr7:158206214 T/G cg09998033 chr7:158218633 PTPRN2 0.41 6.4 0.33 5.31e-10 Obesity-related traits; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg24675658 chr1:53192096 ZYG11B -0.61 -10.15 -0.49 2.93e-21 Monocyte count; LUSC cis rs708547 0.874 rs73242624 chr4:57847420 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -7.28 -0.37 2.34e-12 Response to bleomycin (chromatid breaks); LUSC cis rs61931739 0.513 rs1608906 chr12:33894986 T/C cg06521331 chr12:34319734 NA -0.38 -6.15 -0.32 2.19e-9 Morning vs. evening chronotype; LUSC cis rs1775715 0.870 rs1775735 chr10:32255846 A/G cg18675610 chr10:32216311 ARHGAP12 0.29 6.06 0.31 3.63e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9329221 0.698 rs35388602 chr8:10259188 T/C cg21775007 chr8:11205619 TDH 0.46 6.07 0.32 3.43e-9 Neuroticism; LUSC cis rs9865818 0.702 rs6444285 chr3:188117786 C/T cg23651889 chr3:188115336 LPP -0.38 -5.85 -0.31 1.15e-8 Allergic sensitization; LUSC cis rs243505 0.898 rs243541 chr7:148403243 A/T cg09806900 chr7:148480153 CUL1 -0.48 -6.79 -0.35 5.23e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg14552801 chr7:65878734 NA -0.42 -5.82 -0.3 1.37e-8 Aortic root size; LUSC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg20243544 chr17:37824526 PNMT 0.39 5.89 0.31 9.46e-9 Self-reported allergy; LUSC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg06271696 chr7:157225062 NA -0.45 -8.97 -0.44 2.21e-17 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs7107174 1.000 rs10793295 chr11:77996521 C/G cg02023728 chr11:77925099 USP35 -0.46 -6.67 -0.34 1.06e-10 Testicular germ cell tumor; LUSC cis rs2274273 0.624 rs7151754 chr14:55788501 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.69 0.47 1e-19 Protein biomarker; LUSC trans rs9860340 0.730 rs4859086 chr3:87636057 T/C cg03644585 chr7:884825 UNC84A 0.42 6.09 0.32 3.17e-9 Electroencephalographic traits in alcoholism; LUSC cis rs735396 0.770 rs1169315 chr12:121443753 T/G cg02403541 chr12:121454288 C12orf43 0.7 10.07 0.48 5.15e-21 N-glycan levels; LUSC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg19717773 chr7:2847554 GNA12 -0.39 -6.13 -0.32 2.46e-9 Height; LUSC trans rs4332037 0.615 rs62435127 chr7:1884937 A/G cg10840412 chr1:235813424 GNG4 0.46 6.16 0.32 2.05e-9 Bipolar disorder; LUSC cis rs62027291 0.950 rs56293302 chr15:77286946 T/C cg26408565 chr15:76604113 ETFA 0.54 6.64 0.34 1.3100000000000001e-10 Plateletcrit; LUSC cis rs7726839 0.540 rs72703080 chr5:595238 A/G cg16624210 chr5:671434 TPPP 0.49 6.07 0.32 3.49e-9 Obesity-related traits; LUSC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg19592336 chr6:28129416 ZNF389 0.45 6.0 0.31 5.12e-9 Depression; LUSC cis rs1670533 1.000 rs652063 chr4:1084137 T/C cg27284194 chr4:1044797 NA 0.6 9.03 0.44 1.43e-17 Recombination rate (females); LUSC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.41 5.85 0.3 1.19e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7709377 0.620 rs10066081 chr5:115488569 A/G cg23108291 chr5:115420582 COMMD10 0.41 5.79 0.3 1.59e-8 Metabolite levels (X-11787); LUSC cis rs2282300 0.739 rs35883696 chr11:30246407 A/C cg25418670 chr11:30344373 C11orf46 -0.66 -9.53 -0.46 3.4e-19 Morning vs. evening chronotype; LUSC cis rs12893668 0.608 rs12889721 chr14:104034863 C/T cg08213375 chr14:104286397 PPP1R13B 0.38 6.26 0.32 1.19e-9 Reticulocyte count; LUSC trans rs11577318 1.000 rs11577318 chr1:26601570 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.56 -7.86 -0.4 5.31e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs34779708 0.733 rs7086715 chr10:35541840 A/G cg03585969 chr10:35415529 CREM 0.56 7.81 0.39 7.55e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg13607699 chr17:42295918 UBTF 0.49 7.63 0.39 2.43e-13 Total body bone mineral density; LUSC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg25554036 chr4:6271136 WFS1 0.62 12.77 0.57 1.08e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs55883249 1.000 rs17453724 chr2:9764001 A/G cg23886495 chr2:9695866 ADAM17 0.48 5.76 0.3 1.91e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17621444 0.522 rs4614355 chr10:121811346 G/A cg02041677 chr10:121771263 NA -0.33 -6.21 -0.32 1.6e-9 IgG glycosylation; LUSC cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg24558204 chr6:135376177 HBS1L 0.66 10.03 0.48 7.21e-21 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs11039798 0.588 rs12278284 chr11:48612063 G/C cg03929089 chr4:120376271 NA 0.57 6.29 0.33 9.77e-10 Axial length; LUSC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg12927641 chr6:109611667 NA -0.37 -6.26 -0.32 1.17e-9 Reticulocyte fraction of red cells; LUSC cis rs12545109 0.876 rs4738494 chr8:57327438 G/T cg09654669 chr8:57350985 NA -0.59 -7.86 -0.4 5.41e-14 Obesity-related traits; LUSC cis rs72781680 0.752 rs55801864 chr2:23922325 C/T cg08917208 chr2:24149416 ATAD2B 1.0 10.21 0.49 1.77e-21 Lymphocyte counts; LUSC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg15369054 chr17:80825471 TBCD -0.58 -9.74 -0.47 6.79e-20 Breast cancer; LUSC cis rs7712401 0.546 rs30021 chr5:122285894 G/A cg19077854 chr5:122220652 SNX24 0.44 9.86 0.47 2.76e-20 Mean platelet volume; LUSC trans rs1325195 1.000 rs1325195 chr1:179071756 G/A cg11624085 chr17:8464688 MYH10 -0.46 -7.52 -0.38 5e-13 IgE grass sensitization; LUSC cis rs9359856 0.957 rs9342201 chr6:90310356 G/T cg13799429 chr6:90582589 CASP8AP2 0.58 6.87 0.35 3.11e-11 Bipolar disorder; LUSC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.65 0.39 2.21e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7824557 0.564 rs1435275 chr8:11235735 T/C cg21775007 chr8:11205619 TDH -0.65 -10.3 -0.49 9.02e-22 Retinal vascular caliber; LUSC trans rs4332037 0.539 rs1533827 chr7:2074290 A/G cg25206134 chr2:45395956 NA -0.6 -7.03 -0.36 1.15e-11 Bipolar disorder; LUSC cis rs2050392 1.000 rs2480280 chr10:30696092 A/G cg18806716 chr10:30721971 MAP3K8 -0.48 -7.84 -0.39 5.91e-14 Inflammatory bowel disease; LUSC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs6120849 0.754 rs6087666 chr20:33640242 G/A cg24642439 chr20:33292090 TP53INP2 0.6 6.58 0.34 1.8e-10 Protein C levels; LUSC cis rs1018836 0.828 rs4734250 chr8:91591239 C/G cg16814680 chr8:91681699 NA 0.68 11.07 0.52 1.8e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs3862030 0.720 rs12569526 chr10:104237007 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.59 -9.29 -0.45 2.04e-18 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg05855489 chr10:104503620 C10orf26 0.6 8.74 0.43 1.13e-16 Arsenic metabolism; LUSC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs4242434 0.854 rs13258100 chr8:22451116 A/T cg03733263 chr8:22462867 KIAA1967 0.97 16.8 0.68 2.35e-46 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg13206674 chr6:150067644 NUP43 0.58 8.99 0.44 1.93e-17 Lung cancer; LUSC cis rs3733631 1.000 rs11943988 chr4:104654699 A/G cg24090629 chr4:104641072 TACR3 -0.48 -5.99 -0.31 5.54e-9 Menarche (age at onset); LUSC trans rs11098499 0.909 rs35165976 chr4:120325630 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg02423579 chr7:2872169 GNA12 -0.49 -6.96 -0.36 1.8e-11 Height; LUSC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg00074818 chr8:8560427 CLDN23 0.6 9.86 0.47 2.72e-20 Obesity-related traits; LUSC cis rs10504073 0.647 rs4873098 chr8:50021041 T/C cg00325661 chr8:49890786 NA 0.63 10.7 0.51 3.73e-23 Blood metabolite ratios; LUSC trans rs617791 0.530 rs10896073 chr11:65762814 T/C cg17712092 chr4:129076599 LARP1B -0.73 -10.22 -0.49 1.68e-21 Breast cancer; LUSC cis rs950169 0.922 rs4842941 chr15:84831312 G/C cg12863693 chr15:85201151 NMB -0.35 -7.24 -0.37 3.1e-12 Schizophrenia; LUSC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg17330251 chr7:94953956 PON1 -0.37 -5.94 -0.31 7.09e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.42e-16 Menopause (age at onset); LUSC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.28 0.32 1.08e-9 Tonsillectomy; LUSC cis rs7760535 0.811 rs1002475 chr6:111709589 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.36 2e-11 Metabolic traits; LUSC trans rs72674100 1.000 rs28523751 chr4:97964750 T/A cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -6.13 -0.32 2.44e-9 Developmental language disorder (linguistic errors); LUSC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg17211192 chr8:82754475 SNX16 -0.6 -8.51 -0.42 5.97e-16 Diastolic blood pressure; LUSC cis rs7824557 0.767 rs11775635 chr8:11164865 G/A cg21775007 chr8:11205619 TDH 0.71 11.38 0.53 1.44e-25 Retinal vascular caliber; LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg14789911 chr21:47582049 C21orf56 -0.39 -6.12 -0.32 2.58e-9 Testicular germ cell tumor; LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg12432903 chr7:1882776 MAD1L1 -0.5 -8.19 -0.41 5.54e-15 Autism spectrum disorder or schizophrenia; LUSC cis rs4595586 0.545 rs11615584 chr12:39409350 C/G cg13010199 chr12:38710504 ALG10B 0.46 6.51 0.34 2.82e-10 Morning vs. evening chronotype; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg25767906 chr1:53392781 SCP2 -0.66 -13.03 -0.58 1.13e-31 Monocyte count; LUSC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg12403142 chr1:92012408 NA -0.38 -6.08 -0.32 3.26e-9 Breast cancer; LUSC cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg01973587 chr1:228161476 NA 0.47 8.47 0.42 8.1e-16 Diastolic blood pressure; LUSC cis rs7267979 0.934 rs2257464 chr20:25265872 C/T cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.41e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg18512352 chr11:47633146 NA 0.47 9.45 0.46 5.94e-19 Subjective well-being; LUSC cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg03146154 chr1:46216737 IPP 0.52 7.83 0.39 6.52e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.31 0.49 8.3e-22 Bladder cancer; LUSC cis rs11190604 1.000 rs10883509 chr10:102296461 C/T cg16342193 chr10:102329863 NA -0.36 -6.6 -0.34 1.66e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg05347473 chr6:146136440 FBXO30 0.53 9.17 0.45 5.12e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg23649088 chr2:200775458 C2orf69 -0.54 -6.96 -0.36 1.85e-11 Schizophrenia; LUSC cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg27446573 chr6:127587934 RNF146 0.87 14.03 0.61 1.77e-35 Breast cancer; LUSC cis rs7584330 0.826 rs72620825 chr2:238381243 G/A cg16989719 chr2:238392110 NA -0.45 -6.93 -0.35 2.13e-11 Prostate cancer; LUSC cis rs968451 0.547 rs738331 chr22:39714216 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.82 14.64 0.63 7.6e-38 Primary biliary cholangitis; LUSC cis rs988712 0.705 rs4923461 chr11:27656910 A/G cg10635145 chr11:27742435 BDNF -0.48 -6.28 -0.33 1.04e-9 Obesity; LUSC cis rs1322512 1.000 rs1290296 chr6:153010088 A/C cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg19046167 chr17:80928561 B3GNTL1 -0.46 -6.6 -0.34 1.66e-10 Breast cancer; LUSC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg06671706 chr8:8559999 CLDN23 -0.45 -6.16 -0.32 2.04e-9 Obesity-related traits; LUSC cis rs3126085 0.935 rs4534386 chr1:152251714 A/G cg26876637 chr1:152193138 HRNR 0.46 6.38 0.33 6.03e-10 Atopic dermatitis; LUSC trans rs8072100 0.967 rs4239162 chr17:45755810 G/A cg04995722 chr7:26192034 NFE2L3 -0.36 -5.97 -0.31 5.96e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs727505 1.000 rs1541418 chr7:124448672 A/G cg23710748 chr7:124431027 NA -0.42 -7.5 -0.38 5.88e-13 Lewy body disease; LUSC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.16 -0.41 6.93e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4595586 0.545 rs4623945 chr12:39364572 A/T cg13010199 chr12:38710504 ALG10B 0.42 6.12 0.32 2.66e-9 Morning vs. evening chronotype; LUSC cis rs11264213 0.681 rs72659656 chr1:36176131 G/A cg27506609 chr1:36549197 TEKT2 0.54 6.0 0.31 5.06e-9 Schizophrenia; LUSC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg21361702 chr7:150065534 REPIN1 0.57 8.04 0.4 1.59e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs7917772 0.582 rs4919663 chr10:104363293 T/C cg05855489 chr10:104503620 C10orf26 -0.48 -7.41 -0.38 1.04e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.24e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs9291683 0.935 rs1860910 chr4:10275470 T/G cg26043149 chr18:55253948 FECH 0.48 7.33 0.37 1.77e-12 Bone mineral density; LUSC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg20573242 chr4:122745356 CCNA2 0.56 8.25 0.41 3.75e-15 Type 2 diabetes; LUSC cis rs983392 0.678 rs1562990 chr11:60023087 C/A cg20284999 chr11:59952153 MS4A6A 0.39 6.51 0.34 2.82e-10 Alzheimer's disease (late onset); LUSC trans rs79976124 0.842 rs1548154 chr6:66624910 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.66 7.94 0.4 3.07e-14 Type 2 diabetes; LUSC cis rs7771547 0.573 rs629297 chr6:36398146 C/T cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.02 15.05 0.64 1.93e-39 Age-related macular degeneration (geographic atrophy); LUSC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg13390004 chr1:15929781 NA 0.4 6.64 0.34 1.3100000000000001e-10 Systolic blood pressure; LUSC cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.19 0.64 5.56e-40 Bladder cancer; LUSC cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg03146154 chr1:46216737 IPP -0.6 -8.74 -0.43 1.15e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg23625390 chr15:77176239 SCAPER 0.46 6.99 0.36 1.46e-11 Blood metabolite levels; LUSC cis rs59698941 0.943 rs72799498 chr5:132291157 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.31 -0.33 8.88e-10 Apolipoprotein A-IV levels; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg22166914 chr1:53195759 ZYG11B -0.61 -10.23 -0.49 1.51e-21 Monocyte count; LUSC cis rs10464366 0.560 rs12672089 chr7:39132816 G/A cg18850127 chr7:39170497 POU6F2 0.59 9.11 0.45 7.84e-18 IgG glycosylation; LUSC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg17724175 chr1:150552817 MCL1 0.37 6.73 0.35 7.38e-11 Melanoma; LUSC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg07936489 chr17:37558343 FBXL20 0.71 9.69 0.47 1e-19 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.519 rs28539191 chr4:98821552 C/T cg03676636 chr4:99064102 C4orf37 0.31 5.98 0.31 5.88e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9790314 0.560 rs1450521 chr3:161091237 C/A cg03342759 chr3:160939853 NMD3 -0.43 -6.26 -0.32 1.2e-9 Morning vs. evening chronotype; LUSC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg10128416 chr1:75198403 TYW3;CRYZ 0.48 7.54 0.38 4.62e-13 Resistin levels; LUSC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg13647721 chr17:30228624 UTP6 0.53 5.73 0.3 2.25e-8 Hip circumference adjusted for BMI; LUSC trans rs11098499 0.657 rs71614442 chr4:120379346 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.46 0.33 3.67e-10 Corneal astigmatism; LUSC cis rs7914558 1.000 rs7896547 chr10:104866958 A/G cg23093090 chr10:104574429 C10orf26 -0.37 -6.93 -0.35 2.15e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4268898 0.722 rs11680491 chr2:24416292 T/A cg06627628 chr2:24431161 ITSN2 0.62 8.87 0.44 4.39e-17 Asthma; LUSC cis rs7759001 0.817 rs4562132 chr6:27343285 C/A cg18711553 chr6:27366782 ZNF391 0.42 6.03 0.31 4.37e-9 Glomerular filtration rate (creatinine); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg07316298 chr16:32823289 NA 0.44 6.07 0.32 3.49e-9 Calcium levels; LUSC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.85 -0.63 1.22e-38 Total body bone mineral density; LUSC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -7.43 -0.38 9.25e-13 Personality dimensions; LUSC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg23711669 chr6:146136114 FBXO30 -0.82 -14.7 -0.63 4.6e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg04346459 chr6:41068666 NFYA;LOC221442 0.45 7.15 0.36 5.46e-12 Alzheimer's disease (late onset); LUSC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs983392 0.792 rs493692 chr11:59909610 A/G cg24026212 chr11:59952134 MS4A6A -0.31 -5.71 -0.3 2.45e-8 Alzheimer's disease (late onset); LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.27 -0.37 2.59e-12 Bipolar disorder; LUSC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs1595825 0.891 rs41468149 chr2:198910107 C/G cg00982548 chr2:198649783 BOLL 0.55 6.85 0.35 3.46e-11 Ulcerative colitis; LUSC cis rs9527 0.615 rs10883781 chr10:104581130 A/G cg23093090 chr10:104574429 C10orf26 -0.41 -6.9 -0.35 2.57e-11 Arsenic metabolism; LUSC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg07061783 chr6:25882402 NA 0.39 6.22 0.32 1.46e-9 Blood metabolite levels; LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.83 0.6 1.02e-34 Platelet count; LUSC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg05347473 chr6:146136440 FBXO30 0.53 9.28 0.45 2.26e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg13939156 chr17:80058883 NA 0.34 6.56 0.34 2.01e-10 Life satisfaction; LUSC cis rs2625529 0.617 rs2957365 chr15:72348106 C/T cg16672083 chr15:72433130 SENP8 0.49 8.19 0.41 5.72e-15 Red blood cell count; LUSC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg16423285 chr20:60520624 NA -0.47 -5.94 -0.31 6.99e-9 Body mass index; LUSC cis rs6120849 0.754 rs6088691 chr20:33633758 C/T cg24642439 chr20:33292090 TP53INP2 0.6 6.58 0.34 1.8e-10 Protein C levels; LUSC cis rs644799 0.710 rs12273579 chr11:95524421 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.86 0.6 8.34e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg22166914 chr1:53195759 ZYG11B -0.62 -10.29 -0.49 9.65e-22 Monocyte count; LUSC cis rs3820928 0.845 rs4234065 chr2:227882006 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.8 -0.39 7.97e-14 Pulmonary function; LUSC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg21724239 chr8:58056113 NA 0.74 8.15 0.41 7.47e-15 Developmental language disorder (linguistic errors); LUSC cis rs7113850 0.541 rs76005477 chr11:24233322 G/A ch.11.24196551F chr11:24239977 NA 1.01 9.09 0.45 8.71e-18 Bone fracture in osteoporosis; LUSC cis rs7188861 0.681 rs12928822 chr16:11403893 C/T cg00044050 chr16:11439710 C16orf75 0.59 6.55 0.34 2.15e-10 HDL cholesterol; LUSC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg05738196 chr6:26577821 NA -0.48 -7.11 -0.36 6.88e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs9300255 0.602 rs1716177 chr12:123655457 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.33 -0.33 7.98e-10 Neutrophil percentage of white cells; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg04267008 chr7:1944627 MAD1L1 -0.53 -8.14 -0.41 7.97e-15 Autism spectrum disorder or schizophrenia; LUSC cis rs9653442 0.527 rs12712064 chr2:100756548 C/T cg07810366 chr2:100720526 AFF3 -0.45 -7.64 -0.39 2.32e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg17385448 chr1:15911702 AGMAT 0.34 5.68 0.3 2.97e-8 Systolic blood pressure; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg13866156 chr1:1669148 SLC35E2 -0.5 -8.05 -0.4 1.47e-14 Body mass index; LUSC trans rs8072100 0.840 rs12452796 chr17:45479733 G/T cg03886242 chr7:26192032 NFE2L3 0.38 6.29 0.33 1.02e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6894268 0.722 rs6422331 chr5:179002951 G/T cg26135573 chr5:179059668 NA 0.54 6.59 0.34 1.71e-10 Eating disorders; LUSC cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg07148914 chr20:33460835 GGT7 -0.52 -8.11 -0.41 1e-14 Glomerular filtration rate (creatinine); LUSC cis rs698813 0.604 rs768006 chr2:44487612 C/G cg00619915 chr2:44497795 NA -0.53 -7.55 -0.38 4.09e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg16325326 chr1:53192061 ZYG11B -0.7 -11.5 -0.53 5.18e-26 Monocyte count; LUSC cis rs9392556 0.829 rs689308 chr6:4127730 A/C cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -6.48 -0.33 3.38e-10 Blood metabolite levels; LUSC cis rs9467773 0.620 rs2451732 chr6:26622904 A/T cg05738196 chr6:26577821 NA -0.79 -15.08 -0.64 1.47e-39 Intelligence (multi-trait analysis); LUSC trans rs1997103 0.863 rs6956287 chr7:55415107 T/C cg20935933 chr6:143382018 AIG1 0.5 6.92 0.35 2.28e-11 QRS interval (sulfonylurea treatment interaction); LUSC trans rs656319 0.580 rs13252589 chr8:10005526 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.38 -0.37 1.23e-12 Myopia (pathological); LUSC cis rs9611565 0.921 rs3927 chr22:41722864 A/G cg03806693 chr22:41940476 POLR3H -0.77 -11.4 -0.53 1.22e-25 Vitiligo; LUSC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.44 0.33 4.07e-10 Menopause (age at onset); LUSC cis rs28374715 0.532 rs28897479 chr15:41690851 T/G cg18705301 chr15:41695430 NDUFAF1 -1.03 -20.63 -0.75 1.46e-61 Ulcerative colitis; LUSC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs11039100 0.607 rs2133264 chr11:5781533 G/A cg05234568 chr11:5960015 NA -0.43 -5.7 -0.3 2.66e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs62400317 0.859 rs12201899 chr6:45298204 C/A cg18551225 chr6:44695536 NA -0.44 -7.35 -0.37 1.54e-12 Total body bone mineral density; LUSC cis rs11864453 0.713 rs3764312 chr16:72125733 A/C cg01557791 chr16:72042693 DHODH -0.52 -7.54 -0.38 4.42e-13 Fibrinogen levels; LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg16482183 chr6:26056742 HIST1H1C -0.76 -9.8 -0.47 4.38e-20 Iron status biomarkers; LUSC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg10356904 chr22:49881777 NA -0.35 -8.01 -0.4 1.92e-14 Monocyte count;Monocyte percentage of white cells; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg11909976 chr19:59055696 TRIM28 -0.55 -6.09 -0.32 3.03e-9 Height; LUSC cis rs738322 0.553 rs28565947 chr22:38570775 C/G cg25457927 chr22:38595422 NA -0.36 -7.13 -0.36 6.36e-12 Cutaneous nevi; LUSC trans rs2204008 0.774 rs11495721 chr12:38337224 A/C cg06521331 chr12:34319734 NA -0.4 -6.24 -0.32 1.3e-9 Bladder cancer; LUSC cis rs2976388 1.000 rs2585179 chr8:143774193 G/A cg17252645 chr8:143867129 LY6D -0.38 -6.5 -0.34 2.85e-10 Urinary tract infection frequency; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg09033563 chr22:24373618 LOC391322 -0.57 -8.58 -0.43 3.57e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.86 0.44 4.86e-17 Prudent dietary pattern; LUSC trans rs2490361 0.933 rs2490364 chr1:237322593 A/G cg15653282 chr18:11689218 GNAL 0.4 6.24 0.32 1.29e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs11971779 0.711 rs6961204 chr7:139047399 T/G cg07862535 chr7:139043722 LUC7L2 0.69 8.08 0.4 1.19e-14 Diisocyanate-induced asthma; LUSC trans rs1941687 0.797 rs7227708 chr18:31393091 A/G cg27147174 chr7:100797783 AP1S1 -0.45 -6.56 -0.34 2.04e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs753778 0.570 rs6578154 chr8:142210057 G/A cg18755752 chr8:142205143 DENND3 -0.69 -12.24 -0.56 1.05e-28 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs497273 0.534 rs9431 chr12:121202664 A/C cg02419362 chr12:121203948 SPPL3 0.43 7.95 0.4 2.9e-14 Systemic lupus erythematosus; LUSC cis rs2204008 0.545 rs1663283 chr12:38132039 G/A cg26384229 chr12:38710491 ALG10B -0.67 -10.45 -0.5 2.71e-22 Bladder cancer; LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg21724239 chr8:58056113 NA 0.8 8.55 0.42 4.58e-16 Developmental language disorder (linguistic errors); LUSC trans rs9329221 0.725 rs11250001 chr8:10255901 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -6.89 -0.35 2.74e-11 Neuroticism; LUSC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg17385448 chr1:15911702 AGMAT 0.35 5.92 0.31 7.87e-9 Systolic blood pressure; LUSC cis rs501916 1.000 rs565627 chr15:48056735 A/C cg16110827 chr15:48056943 SEMA6D -0.34 -5.66 -0.3 3.32e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg15448220 chr1:150897856 SETDB1 0.42 6.06 0.31 3.68e-9 Melanoma; LUSC cis rs4268898 0.552 rs12621083 chr2:24367540 C/T cg06627628 chr2:24431161 ITSN2 0.52 7.34 0.37 1.66e-12 Asthma; LUSC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.45 -6.59 -0.34 1.73e-10 Alzheimer's disease (late onset); LUSC cis rs9300255 0.568 rs1627724 chr12:123638580 T/A cg00376283 chr12:123451042 ABCB9 0.67 8.44 0.42 9.73e-16 Neutrophil percentage of white cells; LUSC trans rs7615952 0.609 rs13088451 chr3:125553499 G/C cg02007433 chr3:129722099 NA -0.44 -5.99 -0.31 5.49e-9 Blood pressure (smoking interaction); LUSC cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg03146154 chr1:46216737 IPP -0.5 -7.24 -0.37 3.08e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg26028573 chr6:26043587 HIST1H2BB 0.38 5.69 0.3 2.76e-8 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg06618935 chr21:46677482 NA -0.35 -7.06 -0.36 9.74e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.2 -0.37 4.13e-12 Bipolar disorder; LUSC cis rs12478296 0.515 rs13412492 chr2:243000583 T/G cg06360820 chr2:242988706 NA -0.66 -8.26 -0.41 3.39e-15 Obesity-related traits; LUSC cis rs6695223 1.000 rs4907132 chr1:85537522 T/C cg22153463 chr1:85462885 MCOLN2 -0.58 -5.68 -0.3 2.97e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg00864171 chr11:67383662 NA 0.34 6.01 0.31 4.84e-9 Mean corpuscular volume; LUSC trans rs61931739 0.517 rs1843738 chr12:34056935 C/T cg13010199 chr12:38710504 ALG10B 0.55 8.38 0.42 1.44e-15 Morning vs. evening chronotype; LUSC cis rs8017423 0.967 rs8009493 chr14:90690083 G/C cg04374321 chr14:90722782 PSMC1 0.72 11.42 0.53 1.05e-25 Mortality in heart failure; LUSC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg13393036 chr8:95962371 TP53INP1 -0.45 -9.43 -0.46 7.28e-19 Type 2 diabetes; LUSC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.81 0.65 2.04e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9837602 1.000 rs1688772 chr3:99503366 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -6.04 -0.31 4.08e-9 Breast cancer; LUSC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg21385522 chr1:16154831 NA 1.03 19.78 0.73 3.36e-58 Dilated cardiomyopathy; LUSC cis rs7582720 1.000 rs72932780 chr2:203695826 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.78 0.43 8.49e-17 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg11812906 chr14:75593930 NEK9 0.66 11.33 0.53 2.12e-25 Height; LUSC cis rs68170813 0.559 rs6967638 chr7:106929356 T/G cg02696742 chr7:106810147 HBP1 -0.65 -9.78 -0.47 4.93e-20 Coronary artery disease; LUSC trans rs11700980 0.551 rs2832022 chr21:30112718 G/A cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC trans rs9473924 1.000 rs9473924 chr6:50834157 A/C cg22375689 chr19:34175036 CHST8 -0.38 -6.08 -0.32 3.21e-9 Body mass index; LUSC cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg22782873 chr19:19639568 YJEFN3 -0.53 -6.45 -0.33 3.94e-10 Bipolar disorder; LUSC cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg09184832 chr6:79620586 NA -0.44 -7.17 -0.37 4.8e-12 Intelligence (multi-trait analysis); LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg06877462 chr1:205807181 PM20D1 0.48 8.57 0.42 3.94e-16 Menarche (age at onset); LUSC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg14668632 chr7:2872130 GNA12 -0.47 -6.84 -0.35 3.89e-11 Height; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg21782813 chr7:2030301 MAD1L1 0.49 8.47 0.42 7.92e-16 Bipolar disorder and schizophrenia; LUSC cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg17845761 chr1:175162550 KIAA0040 -0.3 -5.77 -0.3 1.76e-8 Alcohol dependence; LUSC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg06008330 chr7:65541103 ASL -0.4 -6.23 -0.32 1.43e-9 Aortic root size; LUSC cis rs8014204 1.000 rs8014204 chr14:75322794 A/G cg06637938 chr14:75390232 RPS6KL1 0.64 10.52 0.5 1.47e-22 Caffeine consumption; LUSC cis rs7597155 0.935 rs7567400 chr2:69981295 A/G cg02498382 chr2:70120550 SNRNP27 0.24 5.69 0.3 2.74e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs524023 0.914 rs4930556 chr11:64377726 G/C cg07220939 chr11:64358617 SLC22A12 -0.22 -5.72 -0.3 2.3e-8 Urate levels in obese individuals; LUSC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg27398817 chr8:82754497 SNX16 -0.65 -8.11 -0.41 9.85e-15 Diastolic blood pressure; LUSC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg15485101 chr11:133734466 NA 0.42 7.65 0.39 2.19e-13 Childhood ear infection; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg10360139 chr7:1886902 MAD1L1 -0.38 -5.65 -0.3 3.35e-8 Bipolar disorder and schizophrenia; LUSC cis rs1055129 0.560 rs9891076 chr17:73911715 C/T cg19302996 chr17:73780495 UNK -0.48 -7.01 -0.36 1.32e-11 White matter hyperintensity burden; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17822314 chr2:54198336 PSME4 -0.46 -6.56 -0.34 1.99e-10 Electrocardiographic conduction measures; LUSC cis rs11676348 0.811 rs13027120 chr2:219020914 C/T cg06547715 chr2:218990976 CXCR2 -0.32 -6.42 -0.33 4.76e-10 Ulcerative colitis; LUSC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg10351095 chr21:47802916 PCNT 0.43 6.12 0.32 2.64e-9 Testicular germ cell tumor; LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.59 -7.95 -0.4 2.93e-14 Systemic lupus erythematosus; LUSC cis rs7017697 1.000 rs2410612 chr8:19681647 A/G cg03894339 chr8:19674705 INTS10 0.43 6.2 0.32 1.68e-9 Breast cancer; LUSC cis rs28647808 0.881 rs28461467 chr9:136261288 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs11229555 0.645 rs4517537 chr11:58213695 G/A cg15696309 chr11:58395628 NA -0.64 -7.7 -0.39 1.51e-13 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg25036284 chr2:26402008 FAM59B -0.74 -10.66 -0.5 4.96e-23 Gut microbiome composition (summer); LUSC cis rs4950928 0.823 rs2494277 chr1:203168092 A/G cg17014757 chr1:203156097 CHI3L1 -0.41 -7.28 -0.37 2.43e-12 YKL-40 levels; LUSC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg05340658 chr4:99064831 C4orf37 0.64 11.06 0.52 1.91e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7799006 0.691 rs10447541 chr7:2301578 T/G cg08027265 chr7:2291960 NA -0.63 -11.23 -0.52 4.8e-25 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23279559 chr21:17101917 USP25 0.4 6.18 0.32 1.92e-9 Triglycerides; LUSC trans rs17685 0.784 rs1613890 chr7:75735037 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.78e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs8067354 0.872 rs1295925 chr17:57910263 T/C cg02344993 chr17:57696989 CLTC -0.37 -5.65 -0.3 3.42e-8 Hemoglobin concentration; LUSC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6426558 0.537 rs6662583 chr1:227383889 A/G cg10327440 chr1:227177885 CDC42BPA -0.54 -7.55 -0.38 4.32e-13 Neutrophil percentage of white cells; LUSC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg24549020 chr5:56110836 MAP3K1 0.49 5.99 0.31 5.58e-9 Initial pursuit acceleration; LUSC cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg07382826 chr16:28625726 SULT1A1 0.28 6.1 0.32 2.93e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs894344 0.650 rs11166592 chr8:135577008 A/C cg17885191 chr8:135476712 NA 0.41 5.88 0.31 9.98e-9 Systolic blood pressure; LUSC trans rs6582630 0.519 rs11519914 chr12:38287014 A/G cg06521331 chr12:34319734 NA -0.42 -6.53 -0.34 2.48e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs3857536 0.740 rs7769722 chr6:66891363 C/T cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs7772486 0.875 rs1330939 chr6:146308518 T/A cg05347473 chr6:146136440 FBXO30 0.52 8.69 0.43 1.64e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7605827 0.930 rs9287660 chr2:15595767 C/A cg19274914 chr2:15703543 NA 0.46 8.76 0.43 1e-16 Educational attainment (years of education); LUSC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg12365402 chr11:9010492 NRIP3 0.45 8.51 0.42 5.87e-16 Hemoglobin concentration; LUSC cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg04450456 chr4:17643702 FAM184B 0.38 6.22 0.32 1.46e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg24642439 chr20:33292090 TP53INP2 -0.48 -7.33 -0.37 1.7e-12 Glomerular filtration rate (creatinine); LUSC cis rs8017423 0.935 rs11624246 chr14:90734826 A/G cg04374321 chr14:90722782 PSMC1 -0.68 -10.26 -0.49 1.17e-21 Mortality in heart failure; LUSC cis rs16854884 0.657 rs6769910 chr3:143737830 C/G cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg06112835 chr11:68658793 MRPL21 0.49 7.44 0.38 8.49e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9457247 0.765 rs3752520 chr6:167436159 T/C cg25258033 chr6:167368657 RNASET2 0.43 6.86 0.35 3.31e-11 Crohn's disease; LUSC cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.16 -0.52 8.55e-25 Mean corpuscular volume; LUSC cis rs1160297 0.585 rs2356681 chr2:53097750 C/T cg07782112 chr2:53107842 NA 0.43 6.96 0.36 1.83e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg00933542 chr6:150070202 PCMT1 0.3 5.89 0.31 9.66e-9 Lung cancer; LUSC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg04478727 chr12:58166393 METTL1;FAM119B -0.5 -7.01 -0.36 1.33e-11 Multiple sclerosis; LUSC trans rs801193 0.591 rs9986881 chr7:66173040 A/G cg04775059 chr7:64541387 NA 0.44 6.35 0.33 6.86e-10 Aortic root size; LUSC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 8.51 0.42 6.05e-16 Height; LUSC cis rs9660992 0.762 rs1172137 chr1:205246061 G/T cg21643547 chr1:205240462 TMCC2 -0.48 -9.39 -0.46 9.37e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg14893161 chr1:205819251 PM20D1 0.58 9.9 0.48 1.96e-20 Menarche (age at onset); LUSC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.44 5.96 0.31 6.31e-9 Schizophrenia; LUSC cis rs6684514 0.961 rs72710222 chr1:156285995 T/C cg16558208 chr1:156270281 VHLL 0.36 5.76 0.3 1.9e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.75 0.77 5.71e-66 Prudent dietary pattern; LUSC cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg18681998 chr4:17616180 MED28 -0.84 -14.78 -0.63 2.26e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs4919087 0.961 rs11189120 chr10:99069493 G/T cg25902810 chr10:99078978 FRAT1 0.49 7.28 0.37 2.46e-12 Monocyte count; LUSC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg22535103 chr8:58192502 C8orf71 -0.67 -7.23 -0.37 3.25e-12 Developmental language disorder (linguistic errors); LUSC cis rs10751667 0.600 rs14346 chr11:1011829 T/C ch.11.42038R chr11:967971 AP2A2 0.45 6.58 0.34 1.79e-10 Alzheimer's disease (late onset); LUSC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg02569458 chr12:86230093 RASSF9 0.52 8.31 0.41 2.4e-15 Major depressive disorder; LUSC cis rs28647808 0.881 rs41297211 chr9:136260721 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.88 0.58 4.32e-31 Platelet count; LUSC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg12560992 chr17:57184187 TRIM37 0.85 15.35 0.64 1.26e-40 Intelligence (multi-trait analysis); LUSC cis rs735860 0.712 rs3736732 chr6:53160383 G/T cg10236188 chr6:53219634 NA -0.38 -5.93 -0.31 7.77e-9 Glaucoma; LUSC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg19622623 chr12:86230825 RASSF9 0.4 5.81 0.3 1.46e-8 Major depressive disorder; LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.93 0.44 2.98e-17 Prudent dietary pattern; LUSC cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.5 -0.34 2.94e-10 Arsenic metabolism; LUSC cis rs6733011 0.582 rs6757099 chr2:99415235 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.29 -0.33 1.01e-9 Bipolar disorder; LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg00106254 chr7:1943704 MAD1L1 -0.41 -5.89 -0.31 9.27e-9 Bipolar disorder and schizophrenia; LUSC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg05872129 chr22:39784769 NA -0.59 -9.99 -0.48 9.71e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6496667 0.510 rs7495784 chr15:91068882 T/C cg22089800 chr15:90895588 ZNF774 -0.58 -8.12 -0.41 9e-15 Rheumatoid arthritis; LUSC cis rs7296418 0.961 rs12425850 chr12:123501972 T/C cg00376283 chr12:123451042 ABCB9 0.83 13.0 0.58 1.47e-31 Platelet count; LUSC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg04518342 chr5:131593106 PDLIM4 0.35 6.4 0.33 5.25e-10 Lung function (FEV1/FVC); LUSC trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg15704280 chr7:45808275 SEPT13 0.88 12.77 0.57 1.12e-30 Coronary artery disease; LUSC cis rs2348418 0.715 rs4931083 chr12:28721885 A/G cg13890972 chr12:28721907 NA 0.38 6.73 0.35 7.52e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs394563 0.591 rs6570964 chr6:149691859 G/A cg03678062 chr6:149772716 ZC3H12D 0.31 6.29 0.33 9.8e-10 Dupuytren's disease; LUSC cis rs2522056 0.808 rs17771891 chr5:131744202 A/G cg24060327 chr5:131705240 SLC22A5 -0.44 -6.11 -0.32 2.77e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs1728785 1.000 rs864742 chr16:68575309 T/C cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg20503657 chr10:835505 NA 1.01 14.17 0.61 4.98e-36 Eosinophil percentage of granulocytes; LUSC cis rs6690583 0.623 rs61768853 chr1:85455707 T/C cg22153463 chr1:85462885 MCOLN2 0.61 5.94 0.31 6.97e-9 Serum sulfate level; LUSC cis rs950776 0.616 rs6495307 chr15:78890321 C/T cg22563815 chr15:78856949 CHRNA5 0.25 6.24 0.32 1.36e-9 Sudden cardiac arrest; LUSC cis rs1451375 0.698 rs1813214 chr7:50637525 A/G cg18232548 chr7:50535776 DDC 0.5 7.6 0.38 3.11e-13 Malaria; LUSC cis rs11098499 0.821 rs28665282 chr4:120384186 C/T cg09307838 chr4:120376055 NA 0.77 11.09 0.52 1.49e-24 Corneal astigmatism; LUSC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg25258033 chr6:167368657 RNASET2 0.46 7.32 0.37 1.85e-12 Crohn's disease; LUSC trans rs7819412 0.540 rs11777355 chr8:11044689 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -5.95 -0.31 6.74e-9 Triglycerides; LUSC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg18827107 chr12:86230957 RASSF9 -0.41 -6.13 -0.32 2.54e-9 Major depressive disorder; LUSC cis rs6546550 0.933 rs6546555 chr2:70135760 A/G cg02498382 chr2:70120550 SNRNP27 -0.29 -7.29 -0.37 2.2e-12 Prevalent atrial fibrillation; LUSC trans rs2727020 0.658 rs7120136 chr11:49384358 A/C cg15704280 chr7:45808275 SEPT13 -1.09 -20.72 -0.75 6.29e-62 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23304886 chr14:102553823 HSP90AA1 -0.44 -6.6 -0.34 1.63e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6690583 0.562 rs11588919 chr1:85442813 A/T cg11262906 chr1:85462892 MCOLN2 0.69 6.57 0.34 1.99e-10 Serum sulfate level; LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg08859206 chr1:53392774 SCP2 0.51 8.65 0.43 2.13e-16 Monocyte count; LUSC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg00509249 chr6:109615579 CCDC162 -0.32 -5.72 -0.3 2.33e-8 Reticulocyte fraction of red cells; LUSC cis rs7512552 0.839 rs11587116 chr1:150451898 A/T cg15654264 chr1:150340011 RPRD2 0.59 9.73 0.47 7.52e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2625529 0.586 rs2306489 chr15:72227471 G/A cg16672083 chr15:72433130 SENP8 0.49 8.11 0.41 9.63e-15 Red blood cell count; LUSC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.29 0.33 1.02e-9 Menopause (age at onset); LUSC cis rs10740039 0.804 rs894384 chr10:62452293 C/G cg18175470 chr10:62150864 ANK3 -0.44 -6.56 -0.34 2e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg27286337 chr10:134555280 INPP5A 0.86 11.76 0.54 5.81e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC trans rs1728785 1.000 rs864741 chr16:68576577 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.65 0.39 2.18e-13 Ulcerative colitis; LUSC trans rs9329221 0.935 rs3750311 chr8:10283602 C/A cg06636001 chr8:8085503 FLJ10661 -0.53 -7.75 -0.39 1.13e-13 Neuroticism; LUSC trans rs9329221 0.638 rs12543645 chr8:10246325 C/G cg15556689 chr8:8085844 FLJ10661 -0.58 -8.19 -0.41 5.48e-15 Neuroticism; LUSC cis rs1865760 0.625 rs9393681 chr6:26008260 A/G cg16482183 chr6:26056742 HIST1H1C 0.49 7.36 0.37 1.46e-12 Height; LUSC cis rs2439831 1.000 rs2467739 chr15:43740196 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.23 0.52 5.01e-25 Lung cancer in ever smokers; LUSC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg25208724 chr1:156163844 SLC25A44 1.01 16.81 0.68 2.16e-46 Testicular germ cell tumor; LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg06600287 chr1:53387719 ECHDC2 0.29 5.94 0.31 7.17e-9 Monocyte count; LUSC cis rs1413885 0.526 rs9728544 chr1:65847105 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.48 7.06 0.36 9.51e-12 Anticoagulant levels; LUSC trans rs6952808 0.782 rs4236271 chr7:1881369 C/T cg11244813 chr1:145039882 PDE4DIP 0.39 6.52 0.34 2.58e-10 Bipolar disorder and schizophrenia; LUSC cis rs9467711 0.606 rs13212985 chr6:26609989 G/C cg09904177 chr6:26538194 HMGN4 -0.75 -5.77 -0.3 1.76e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7481584 0.581 rs105686 chr11:3062467 G/A cg08508325 chr11:3079039 CARS 0.39 8.81 0.43 6.97e-17 Calcium levels; LUSC cis rs4704187 0.687 rs6891023 chr5:74500755 G/A cg03227963 chr5:74354835 NA 0.31 6.76 0.35 6.31e-11 Response to amphetamines; LUSC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg23262073 chr20:60523788 NA -0.39 -6.23 -0.32 1.38e-9 Body mass index; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08007338 chr1:180123948 QSOX1 0.67 6.05 0.31 3.95e-9 Cognitive performance; LUSC cis rs13031619 1.000 rs6724730 chr2:3697987 G/C cg25251562 chr2:3704773 ALLC 0.54 8.89 0.44 3.77e-17 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg16362232 chr11:430036 ANO9 0.57 7.59 0.38 3.18e-13 Body mass index; LUSC cis rs9653442 0.545 rs13415465 chr2:100764004 T/G cg22139774 chr2:100720529 AFF3 -0.43 -7.37 -0.37 1.32e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2708377 0.799 rs61928604 chr12:11311947 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -6.01 -0.31 4.82e-9 Intelligence (multi-trait analysis); LUSC cis rs7599312 0.534 rs10182996 chr2:213404834 T/C cg16329650 chr2:213403929 ERBB4 0.86 18.45 0.71 6.91e-53 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11098499 0.863 rs11731756 chr4:120478696 T/G cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC trans rs11098499 0.863 rs1010739 chr4:120463471 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.4 0.33 5.38e-10 Corneal astigmatism; LUSC cis rs7772486 0.902 rs1125462 chr6:146417832 A/G cg23711669 chr6:146136114 FBXO30 0.75 12.94 0.58 2.6e-31 Lobe attachment (rater-scored or self-reported); LUSC trans rs853679 0.607 rs72854513 chr6:28265954 A/T cg06606381 chr12:133084897 FBRSL1 -0.99 -9.43 -0.46 7.11e-19 Depression; LUSC cis rs62344088 1.000 rs10037843 chr5:120078 G/C cg22857025 chr5:266934 NA -0.99 -7.12 -0.36 6.61e-12 Asthma (childhood onset); LUSC cis rs9815354 0.723 rs12152489 chr3:42060402 T/C cg03022575 chr3:42003672 ULK4 0.78 7.85 0.39 5.64e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs2354432 0.943 rs6660219 chr1:146691404 A/T cg25205988 chr1:146714368 CHD1L 1.09 12.99 0.58 1.62e-31 Mitochondrial DNA levels; LUSC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg26597838 chr10:835615 NA -0.78 -9.69 -0.47 1.02e-19 Eosinophil percentage of granulocytes; LUSC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -9.98 -0.48 1.09e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8.04e-17 Bipolar disorder; LUSC cis rs699 0.556 rs2478520 chr1:230867197 G/A cg07502417 chr1:230849801 AGT 0.27 6.38 0.33 5.92e-10 Coronary artery disease; LUSC cis rs7615316 0.902 rs6440087 chr3:142247052 C/T cg16271453 chr3:142027066 XRN1 -0.4 -6.83 -0.35 3.93e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7586879 0.639 rs6722022 chr2:25098859 A/G cg01884057 chr2:25150051 NA 0.47 10.7 0.51 3.7e-23 Body mass index; LUSC cis rs11122272 0.701 rs743120 chr1:231531232 C/T cg06096015 chr1:231504339 EGLN1 0.58 10.45 0.5 2.68e-22 Hemoglobin concentration; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg13582873 chr2:207024197 EEF1B2;NDUFS1 0.4 6.11 0.32 2.82e-9 Asthma; LUSC cis rs7200543 1.000 rs55727637 chr16:15145252 C/T cg03427771 chr16:15082598 PDXDC1 -0.42 -6.12 -0.32 2.56e-9 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg23649088 chr2:200775458 C2orf69 -0.48 -6.28 -0.33 1.02e-9 Schizophrenia; LUSC trans rs6089829 0.962 rs6011544 chr20:61658782 T/C cg13615516 chr5:77269221 NA 0.4 6.56 0.34 2.02e-10 Prostate cancer (SNP x SNP interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11953916 chr17:11900692 ZNF18 0.41 6.14 0.32 2.33e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs953492 0.672 rs1766030 chr1:243314577 C/T cg01826367 chr1:224180288 NA -0.45 -6.69 -0.34 9.33e-11 Diastolic blood pressure; LUSC cis rs36093844 0.747 rs11234420 chr11:85528580 G/A cg25872744 chr11:85566296 CCDC83 -0.44 -6.02 -0.31 4.5e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg01579765 chr21:45077557 HSF2BP -0.53 -11.18 -0.52 7.13e-25 Mean corpuscular volume; LUSC cis rs12200560 0.505 rs927271 chr6:97075910 T/G cg06623918 chr6:96969491 KIAA0776 0.48 6.93 0.35 2.12e-11 Coronary heart disease; LUSC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg21770322 chr7:97807741 LMTK2 0.4 7.03 0.36 1.19e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07377288 chr7:102004298 NA 0.45 6.08 0.32 3.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28595532 0.623 rs34082100 chr4:119220563 C/T cg21605333 chr4:119757512 SEC24D 0.76 6.34 0.33 7.37e-10 Cannabis dependence symptom count; LUSC cis rs6121246 0.559 rs10439607 chr20:30258541 G/A cg13852791 chr20:30311386 BCL2L1 0.94 14.26 0.62 2.29e-36 Mean corpuscular hemoglobin; LUSC cis rs7147624 1.000 rs2411354 chr14:66062132 T/C cg03016385 chr14:66212404 NA -0.84 -9.37 -0.46 1.12e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10845606 1.000 rs10845607 chr12:12835228 C/T cg09462578 chr12:12878428 APOLD1 -0.53 -6.5 -0.34 2.91e-10 Systemic lupus erythematosus; LUSC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs713587 0.713 rs12618252 chr2:25207950 G/A cg01884057 chr2:25150051 NA -0.38 -8.58 -0.42 3.67e-16 Body mass index in non-asthmatics; LUSC cis rs7103648 0.838 rs11039244 chr11:47466442 G/A cg20307385 chr11:47447363 PSMC3 0.89 14.87 0.63 9.67e-39 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs28647808 0.881 rs28602295 chr9:136267471 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs2658782 0.694 rs3019221 chr11:93079700 C/G cg15737290 chr11:93063684 CCDC67 0.71 8.83 0.44 6.04e-17 Pulmonary function decline; LUSC cis rs2267681 0.603 rs12534299 chr7:139538522 A/G cg14116596 chr7:139528673 TBXAS1 -0.35 -6.13 -0.32 2.55e-9 Cervical cancer; LUSC trans rs7181230 1.000 rs11638521 chr15:40360314 T/C cg22705835 chr10:65332833 REEP3 0.43 7.54 0.38 4.58e-13 Dehydroepiandrosterone sulphate levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12199165 chr10:103577593 MGEA5 -0.56 -6.45 -0.33 3.99e-10 Bipolar disorder and schizophrenia; LUSC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg05623727 chr3:50126028 RBM5 -0.32 -6.08 -0.32 3.23e-9 Intelligence (multi-trait analysis); LUSC cis rs4474465 0.920 rs10899532 chr11:78208470 T/G cg27205649 chr11:78285834 NARS2 0.52 6.11 0.32 2.73e-9 Alzheimer's disease (survival time); LUSC cis rs9929218 0.551 rs1886697 chr16:68716179 T/C cg01251360 chr16:68772225 CDH1 -0.27 -6.51 -0.34 2.82e-10 Colorectal cancer; LUSC cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg19628046 chr18:33552617 C18orf21 0.52 6.34 0.33 7.36e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs9309473 0.948 rs2421577 chr2:73840998 G/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.51 -0.34 2.77e-10 Metabolite levels; LUSC cis rs7089973 0.604 rs11196924 chr10:116571796 A/C cg25233709 chr10:116636983 FAM160B1 -0.38 -6.63 -0.34 1.38e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg12963246 chr6:28129442 ZNF389 0.39 6.05 0.31 3.92e-9 Cardiac Troponin-T levels; LUSC cis rs16949788 1.000 rs76623374 chr15:66767868 C/G cg08120210 chr15:66682733 MAP2K1 -0.63 -6.52 -0.34 2.56e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6901250 0.819 rs9374623 chr6:117127312 C/A cg12892004 chr6:117198278 RFX6 0.43 8.12 0.41 8.98e-15 C-reactive protein levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18877635 chr1:229643817 NUP133 0.44 6.25 0.32 1.24e-9 Triglycerides; LUSC cis rs614226 1.000 rs1167725 chr12:120968559 A/T cg21053147 chr12:120880522 NA -0.49 -6.13 -0.32 2.52e-9 Type 1 diabetes nephropathy; LUSC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9326248 0.813 rs588534 chr11:117068504 A/G cg26566898 chr11:117069891 TAGLN 0.38 6.03 0.31 4.37e-9 Blood protein levels; LUSC cis rs748404 0.660 rs548704 chr15:43791706 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg05165339 chr4:1420672 NA 0.28 6.17 0.32 2.01e-9 Obesity-related traits; LUSC trans rs11098499 0.863 rs17050695 chr4:120489527 G/T cg25214090 chr10:38739885 LOC399744 0.46 7.39 0.37 1.2e-12 Corneal astigmatism; LUSC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg11812906 chr14:75593930 NEK9 -0.64 -10.45 -0.5 2.61e-22 Height; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg09877947 chr5:131593287 PDLIM4 0.43 7.31 0.37 1.99e-12 Blood metabolite levels; LUSC cis rs7666738 0.606 rs3846446 chr4:99099768 C/A cg17366294 chr4:99064904 C4orf37 0.53 9.1 0.45 8.59e-18 Colonoscopy-negative controls vs population controls; LUSC trans rs7695732 0.752 rs1849597 chr4:89934550 A/G cg08621624 chr12:2030223 NA 0.28 6.08 0.32 3.32e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg21724239 chr8:58056113 NA 0.8 8.46 0.42 8.32e-16 Developmental language disorder (linguistic errors); LUSC cis rs2880765 0.835 rs7174323 chr15:86049719 A/C cg13263323 chr15:86062960 AKAP13 -0.36 -5.9 -0.31 8.79e-9 Coronary artery disease; LUSC cis rs1728785 1.000 rs1094282 chr16:68577260 G/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03576123 chr11:487126 PTDSS2 -0.95 -9.99 -0.48 1.02e-20 Body mass index; LUSC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg11189052 chr15:85197271 WDR73 0.47 5.85 0.3 1.18e-8 Schizophrenia; LUSC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11644478 chr21:40555479 PSMG1 0.94 18.89 0.72 1.15e-54 Cognitive function; LUSC cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg06552810 chr11:31128660 NA -0.42 -7.37 -0.37 1.37e-12 Red blood cell count; LUSC cis rs478304 0.651 rs11537193 chr11:65500003 A/C cg10604040 chr11:65559109 OVOL1 0.31 5.72 0.3 2.34e-8 Acne (severe); LUSC cis rs354225 0.544 rs7340302 chr2:54803671 A/C cg01766943 chr2:54829624 SPTBN1 0.47 7.53 0.38 4.81e-13 Schizophrenia; LUSC cis rs2249625 0.545 rs2463746 chr6:72876954 C/G cg18830697 chr6:72922368 RIMS1 -0.36 -7.36 -0.37 1.45e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC trans rs7829975 0.626 rs907183 chr8:8729761 C/G cg21775007 chr8:11205619 TDH -0.48 -6.69 -0.34 9.31e-11 Mood instability; LUSC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.76 -0.47 5.98e-20 Bipolar disorder; LUSC trans rs7615952 0.641 rs60839048 chr3:125807938 G/A cg07211511 chr3:129823064 LOC729375 -0.75 -9.68 -0.47 1.1e-19 Blood pressure (smoking interaction); LUSC trans rs11098499 0.863 rs13140391 chr4:120503437 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.75 0.35 6.4e-11 Corneal astigmatism; LUSC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.2e-9 Life satisfaction; LUSC cis rs12681287 0.752 rs9283958 chr8:87253048 T/C cg27223183 chr8:87520930 FAM82B -0.47 -5.94 -0.31 7.1e-9 Caudate activity during reward; LUSC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg02117656 chr17:79614917 TSPAN10 -0.3 -5.74 -0.3 2.15e-8 Eye color traits; LUSC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs7589342 0.660 rs7571132 chr2:106398913 C/T cg09152813 chr2:106391379 NCK2 -0.4 -6.31 -0.33 8.99e-10 Addiction; LUSC cis rs12908161 0.959 rs2175567 chr15:85200946 C/G cg11189052 chr15:85197271 WDR73 0.48 5.97 0.31 6.23e-9 Schizophrenia; LUSC cis rs1729951 0.546 rs12054218 chr3:136677496 C/G cg12473912 chr3:136751656 NA 0.39 6.77 0.35 5.97e-11 Neuroticism; LUSC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg26597838 chr10:835615 NA 1.23 16.47 0.67 4.98e-45 Eosinophil percentage of granulocytes; LUSC cis rs36093844 0.898 rs11234458 chr11:85591370 A/C cg25872744 chr11:85566296 CCDC83 -0.42 -6.2 -0.32 1.64e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg20476274 chr7:133979776 SLC35B4 -0.8 -14.43 -0.62 5.08e-37 Mean platelet volume; LUSC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg25456477 chr12:86230367 RASSF9 0.44 7.83 0.39 6.31e-14 Major depressive disorder; LUSC cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg07148914 chr20:33460835 GGT7 0.39 5.69 0.3 2.82e-8 Coronary artery disease; LUSC cis rs11608355 1.000 rs10774692 chr12:109862324 G/T cg19025524 chr12:109796872 NA -0.38 -5.94 -0.31 7.28e-9 Neuroticism; LUSC cis rs981844 0.712 rs1456398 chr4:154738266 G/A cg14289246 chr4:154710475 SFRP2 -0.44 -6.13 -0.32 2.46e-9 Response to statins (LDL cholesterol change); LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg07677032 chr17:61819896 STRADA 0.52 8.56 0.42 4.1e-16 Prudent dietary pattern; LUSC cis rs9398803 0.865 rs1361108 chr6:126767600 C/T cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.96e-9 Male-pattern baldness; LUSC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg00990874 chr7:1149470 C7orf50 -0.49 -6.34 -0.33 7.39e-10 Bronchopulmonary dysplasia; LUSC cis rs3087591 0.960 rs8080679 chr17:29602610 A/G cg24425628 chr17:29625626 OMG;NF1 0.55 7.95 0.4 2.97e-14 Hip circumference; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg02222234 chr2:208576132 CCNYL1 0.44 6.4 0.33 5.31e-10 Mosquito bite size; LUSC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg00106254 chr7:1943704 MAD1L1 -0.42 -6.01 -0.31 4.91e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg11494091 chr17:61959527 GH2 0.64 13.62 0.6 6.82e-34 Prudent dietary pattern; LUSC cis rs8064299 0.597 rs2053748 chr17:72775911 A/G cg25054828 chr17:72772726 NAT9;TMEM104 -0.9 -17.03 -0.68 3.05e-47 Monocyte count; LUSC cis rs4555082 0.874 rs28625632 chr14:105748849 G/T cg06808227 chr14:105710500 BRF1 -0.6 -8.7 -0.43 1.58e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs17401966 0.522 rs6541085 chr1:10285709 A/G cg19773385 chr1:10388646 KIF1B -0.37 -6.39 -0.33 5.46e-10 Hepatocellular carcinoma; LUSC cis rs9388451 0.874 rs7739566 chr6:126094757 A/T cg05901451 chr6:126070800 HEY2 -0.95 -18.47 -0.71 5.46e-53 Brugada syndrome; LUSC cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg13010199 chr12:38710504 ALG10B 0.7 11.4 0.53 1.18e-25 Heart rate; LUSC cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.57 -7.3 -0.37 2.18e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg22307029 chr19:49891270 CCDC155 0.63 8.09 0.4 1.13e-14 Multiple sclerosis; LUSC cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg07636037 chr3:49044803 WDR6 -0.65 -8.31 -0.41 2.45e-15 Menarche (age at onset); LUSC cis rs1790761 0.632 rs625978 chr11:67344664 C/T cg08355456 chr11:67383691 NA 0.38 6.98 0.36 1.57e-11 Mean corpuscular volume; LUSC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.37 -5.89 -0.31 9.63e-9 Alzheimer's disease (late onset); LUSC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg12560992 chr17:57184187 TRIM37 0.78 13.83 0.6 1.07e-34 Intelligence (multi-trait analysis); LUSC cis rs1847202 0.859 rs13075769 chr3:72939295 C/T cg25664220 chr3:72788482 NA -0.4 -7.11 -0.36 7.1e-12 Motion sickness; LUSC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg11812906 chr14:75593930 NEK9 -0.67 -11.32 -0.53 2.37e-25 Height; LUSC cis rs3820068 0.822 rs11581917 chr1:15805722 G/A cg17385448 chr1:15911702 AGMAT 0.41 5.7 0.3 2.57e-8 Systolic blood pressure; LUSC cis rs2625529 0.652 rs9302260 chr15:72174611 T/C cg16672083 chr15:72433130 SENP8 0.48 7.87 0.4 4.87e-14 Red blood cell count; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg03461704 chr1:205818484 PM20D1 0.35 5.78 0.3 1.75e-8 Menarche (age at onset); LUSC cis rs6920965 0.507 rs7754833 chr6:126190894 A/G cg05901451 chr6:126070800 HEY2 -0.54 -7.77 -0.39 1e-13 High light scatter reticulocyte count; LUSC cis rs4888262 0.545 rs12716768 chr16:74556486 A/G cg01733217 chr16:74700730 RFWD3 -0.75 -11.57 -0.54 2.81e-26 Testicular germ cell tumor; LUSC cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.83 0.39 6.56e-14 Colorectal cancer; LUSC cis rs9811920 0.535 rs793481 chr3:99488742 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.3 -5.76 -0.3 1.87e-8 Axial length; LUSC cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg05855489 chr10:104503620 C10orf26 0.59 8.76 0.43 9.78e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg01097406 chr16:89675127 NA -0.35 -7.04 -0.36 1.07e-11 Vitiligo; LUSC cis rs34638657 0.687 rs2303261 chr16:82203768 G/T cg09439754 chr16:82129088 HSD17B2 -0.39 -6.58 -0.34 1.78e-10 Lung adenocarcinoma; LUSC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg02569458 chr12:86230093 RASSF9 0.52 8.72 0.43 1.32e-16 Major depressive disorder; LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg07703079 chr11:430292 ANO9 0.65 6.7 0.34 9.13e-11 Body mass index; LUSC cis rs921968 0.565 rs6704575 chr2:219589594 C/T cg02176678 chr2:219576539 TTLL4 0.56 9.63 0.47 1.51e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg20476274 chr7:133979776 SLC35B4 0.87 16.84 0.68 1.7e-46 Mean platelet volume; LUSC cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg05294307 chr14:35346193 BAZ1A -0.61 -7.4 -0.38 1.15e-12 Psoriasis; LUSC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg20090143 chr19:45452003 APOC2 0.49 9.56 0.46 2.6e-19 Blood protein levels; LUSC cis rs739401 0.611 rs402276 chr11:3051404 C/G cg05729581 chr11:3078854 CARS -0.53 -8.11 -0.41 9.45e-15 Longevity; LUSC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg04155289 chr7:94953770 PON1 -0.35 -6.03 -0.31 4.4e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg10802521 chr3:52805072 NEK4 -0.53 -7.43 -0.38 9.41e-13 Bipolar disorder; LUSC cis rs952623 0.611 rs10435033 chr7:39054837 G/A cg15212455 chr7:39170539 POU6F2 0.36 5.92 0.31 7.91e-9 Intelligence (multi-trait analysis); LUSC cis rs10876993 0.749 rs703832 chr12:58024626 G/C cg00268967 chr12:58002603 GEFT;DTX3 0.36 5.68 0.3 2.92e-8 Celiac disease or Rheumatoid arthritis; LUSC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg08270630 chr22:50330655 NA -0.42 -6.17 -0.32 1.94e-9 Schizophrenia; LUSC cis rs2446066 0.659 rs11170566 chr12:53907067 C/T cg20730629 chr12:53886622 MAP3K12 -0.45 -5.94 -0.31 7.17e-9 Red blood cell count; LUSC cis rs10979 1.000 rs6570565 chr6:143899531 C/T cg25407410 chr6:143891975 LOC285740 -0.69 -10.62 -0.5 6.71e-23 Hypospadias; LUSC cis rs9467711 0.591 rs13216785 chr6:26079185 C/T cg21479132 chr6:26055353 NA 0.6 5.65 0.3 3.53e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC trans rs7726839 0.561 rs3915384 chr5:573395 G/T cg11887960 chr12:57824829 NA 0.48 6.52 0.34 2.57e-10 Obesity-related traits; LUSC cis rs7072216 0.763 rs7911036 chr10:100167015 A/T cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC cis rs9807989 0.765 rs6751967 chr2:102967413 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.85 0.3 1.19e-8 Asthma; LUSC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg05234568 chr11:5960015 NA -0.55 -8.69 -0.43 1.64e-16 DNA methylation (variation); LUSC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg10523679 chr1:76189770 ACADM 0.86 14.13 0.61 7.42e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4363385 0.600 rs10888532 chr1:153063407 C/A cg00922841 chr1:152955080 SPRR1A -0.34 -5.91 -0.31 8.64e-9 Inflammatory skin disease; LUSC trans rs2562456 0.678 rs7260140 chr19:21523525 T/C cg00806126 chr19:22604979 ZNF98 -0.43 -6.19 -0.32 1.78e-9 Pain; LUSC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg03579872 chr1:53393473 SCP2 -0.39 -5.87 -0.31 1.05e-8 Monocyte count; LUSC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC trans rs2727020 0.658 rs4980440 chr11:49386017 C/T cg15704280 chr7:45808275 SEPT13 -1.08 -20.36 -0.74 1.77e-60 Coronary artery disease; LUSC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.7 0.3 2.6e-8 Self-reported allergy; LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg04267008 chr7:1944627 MAD1L1 -0.48 -7.03 -0.36 1.2e-11 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.8 -0.39 7.87e-14 Gut microbiome composition (summer); LUSC trans rs9329221 0.618 rs4314693 chr8:10258932 G/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.41 -0.33 4.93e-10 Neuroticism; LUSC cis rs6499188 0.522 rs10153230 chr16:68671741 C/G cg02972257 chr16:68554789 NA -0.49 -6.53 -0.34 2.38e-10 Ulcerative colitis; LUSC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.8 -0.35 4.73e-11 Lung cancer; LUSC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg18512352 chr11:47633146 NA -0.43 -8.62 -0.43 2.82e-16 Subjective well-being; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03208016 chr1:180124071 QSOX1 -0.4 -6.01 -0.31 4.97e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg22549504 chr19:17448937 GTPBP3 0.53 6.64 0.34 1.29e-10 Systemic lupus erythematosus; LUSC cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.34 -0.37 1.65e-12 Glomerular filtration rate (creatinine); LUSC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.52 0.38 5.06e-13 Menarche (age at onset); LUSC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg03929089 chr4:120376271 NA -0.5 -7.01 -0.36 1.29e-11 HDL cholesterol; LUSC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs11711311 0.955 rs7617313 chr3:113391740 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -6.23 -0.32 1.44e-9 IgG glycosylation; LUSC cis rs981844 0.775 rs10517580 chr4:154744128 T/G cg14289246 chr4:154710475 SFRP2 0.46 6.2 0.32 1.66e-9 Response to statins (LDL cholesterol change); LUSC cis rs10771431 0.817 rs10843149 chr12:9362067 G/A cg08997352 chr12:9597637 DDX12 -0.72 -11.4 -0.53 1.17e-25 Breast size; LUSC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg22834771 chr12:69754056 YEATS4 -0.49 -7.4 -0.38 1.13e-12 Blood protein levels; LUSC cis rs394563 0.591 rs6570964 chr6:149691859 G/A cg11245181 chr6:149772854 ZC3H12D 0.3 6.45 0.33 4.03e-10 Dupuytren's disease; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.03 0.77 4.52e-67 Prudent dietary pattern; LUSC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs2692947 0.770 rs11689832 chr2:96554851 A/C cg23100626 chr2:96804247 ASTL 0.3 7.03 0.36 1.18e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg16325326 chr1:53192061 ZYG11B 0.82 14.18 0.61 4.69e-36 Monocyte count; LUSC cis rs2279817 0.863 rs12023877 chr1:18025633 A/C cg21791023 chr1:18019539 ARHGEF10L 0.49 6.97 0.36 1.74e-11 Neuroticism; LUSC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg20283391 chr11:68216788 NA -0.53 -7.99 -0.4 2.17e-14 Total body bone mineral density; LUSC cis rs1982963 0.950 rs1566132 chr14:52511836 C/T cg10843707 chr14:52510701 NID2 -0.4 -7.17 -0.37 4.85e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg03036452 chr22:46663545 TTC38 0.53 5.7 0.3 2.59e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00281600 chr7:149322071 ZNF767 -0.49 -6.37 -0.33 6.31e-10 Bipolar disorder and schizophrenia; LUSC cis rs17826219 0.706 rs8075357 chr17:29057197 A/C cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Body mass index; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.0 0.58 1.45e-31 Platelet count; LUSC cis rs7075426 0.646 rs4934210 chr10:88203667 G/A cg07322936 chr10:88137208 NA 0.41 5.95 0.31 6.83e-9 Migraine without aura; LUSC cis rs7091068 0.522 rs10748612 chr10:95494458 G/A cg20715218 chr10:95462985 C10orf4 0.56 6.72 0.34 8e-11 Urinary tract infection frequency; LUSC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12756686 chr19:29218302 NA 0.68 9.59 0.46 2.11e-19 Methadone dose in opioid dependence; LUSC trans rs61931739 0.517 rs9668303 chr12:34366701 C/T cg26384229 chr12:38710491 ALG10B 0.87 14.93 0.63 5.75e-39 Morning vs. evening chronotype; LUSC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg01657329 chr11:68192670 LRP5 0.45 7.15 0.36 5.67e-12 Total body bone mineral density; LUSC cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg17143192 chr8:8559678 CLDN23 0.62 8.96 0.44 2.26e-17 Obesity-related traits; LUSC cis rs1451375 0.583 rs3779078 chr7:50610918 C/T cg18232548 chr7:50535776 DDC 0.55 7.54 0.38 4.53e-13 Malaria; LUSC cis rs59698941 0.943 rs67268447 chr5:132303194 G/A cg14825688 chr5:132208181 LEAP2 -0.54 -5.75 -0.3 2.01e-8 Apolipoprotein A-IV levels; LUSC cis rs4629180 0.586 rs1509495 chr2:102134834 C/T cg04415270 chr2:102091202 RFX8 -0.46 -7.88 -0.4 4.76e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg02038168 chr22:39784481 NA -0.49 -7.89 -0.4 4.28e-14 Intelligence (multi-trait analysis); LUSC cis rs13217239 0.646 rs7451149 chr6:27057518 A/G cg12292205 chr6:26970375 C6orf41 -0.52 -8.84 -0.44 5.51e-17 Schizophrenia; LUSC cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.83 -0.43 6.13e-17 Monocyte percentage of white cells; LUSC trans rs3857536 0.813 rs9294688 chr6:66945904 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs2439831 0.717 rs2447198 chr15:43895118 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.74 7.12 0.36 6.67e-12 Lung cancer in ever smokers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19573456 chr19:16607087 C19orf44;CALR3 0.68 5.98 0.31 5.85e-9 Cognitive performance; LUSC cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg08085267 chr17:45401833 C17orf57 0.6 9.98 0.48 1.1e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs17095355 1.000 rs958086 chr10:111752548 G/T cg00817464 chr10:111662876 XPNPEP1 -0.65 -8.04 -0.4 1.55e-14 Biliary atresia; LUSC cis rs4285028 0.948 rs12493952 chr3:121708497 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -9.18 -0.45 4.76e-18 Multiple sclerosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02084808 chr1:172413246 PIGC;C1orf105 -0.5 -7.44 -0.38 8.77e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2637266 0.716 rs2579734 chr10:78441306 A/G cg18941641 chr10:78392320 NA 0.33 5.88 0.31 9.92e-9 Pulmonary function; LUSC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08704250 chr15:31115839 NA -0.47 -7.37 -0.37 1.32e-12 Huntington's disease progression; LUSC cis rs4689388 0.926 rs3889821 chr4:6282596 C/T cg14416269 chr4:6271139 WFS1 0.56 12.08 0.55 3.96e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9300255 0.739 rs4759415 chr12:123743674 C/T cg13010344 chr12:123464640 ARL6IP4 0.46 6.28 0.33 1.03e-9 Neutrophil percentage of white cells; LUSC cis rs4654899 0.802 rs12123910 chr1:21233316 C/T cg01072550 chr1:21505969 NA -0.52 -7.49 -0.38 6.09e-13 Superior frontal gyrus grey matter volume; LUSC cis rs12421382 0.636 rs1439519 chr11:109378438 A/G cg11473876 chr11:109292803 C11orf87 0.39 6.3 0.33 9.31e-10 Schizophrenia; LUSC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg13319975 chr6:146136371 FBXO30 -0.52 -7.77 -0.39 9.7e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg14092988 chr3:52407081 DNAH1 0.31 6.02 0.31 4.66e-9 Bipolar disorder; LUSC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11890956 chr21:40555474 PSMG1 1.02 20.28 0.74 3.65e-60 Cognitive function; LUSC trans rs11098499 0.818 rs55825515 chr4:120486402 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.45 0.33 3.82e-10 Corneal astigmatism; LUSC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg06505273 chr16:24850292 NA 0.42 5.76 0.3 1.95e-8 Intelligence (multi-trait analysis); LUSC cis rs8077577 0.895 rs11871491 chr17:18105656 T/C cg16794390 chr17:18148240 FLII 0.41 5.88 0.31 9.85e-9 Obesity-related traits; LUSC cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg06784218 chr1:46089804 CCDC17 0.49 9.84 0.47 3.04e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7584330 0.737 rs6431539 chr2:238360708 G/T cg14458575 chr2:238380390 NA 0.67 11.86 0.54 2.64e-27 Prostate cancer; LUSC trans rs61931739 0.500 rs7310576 chr12:34474735 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.13 0.45 6.73e-18 Morning vs. evening chronotype; LUSC cis rs6424115 1.000 rs7519554 chr1:24154566 T/A cg10978503 chr1:24200527 CNR2 -0.49 -11.59 -0.54 2.39e-26 Immature fraction of reticulocytes; LUSC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg24110177 chr3:50126178 RBM5 0.57 9.36 0.46 1.18e-18 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg20295408 chr7:1910781 MAD1L1 0.45 6.58 0.34 1.85e-10 Bipolar disorder and schizophrenia; LUSC cis rs7582180 0.726 rs4438499 chr2:100876789 A/G cg08017756 chr2:100939284 LONRF2 0.32 5.76 0.3 1.86e-8 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg08999081 chr20:33150536 PIGU 0.45 8.09 0.4 1.11e-14 Coronary artery disease; LUSC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs7568458 0.837 rs35215812 chr2:85792384 G/A cg23752985 chr2:85803571 VAMP8 0.36 7.87 0.4 4.92e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg11266682 chr4:10021025 SLC2A9 -0.51 -9.44 -0.46 6.64e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg13615516 chr5:77269221 NA 0.39 6.63 0.34 1.35e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg11645453 chr3:52864694 ITIH4 0.32 7.41 0.38 1.06e-12 Bipolar disorder; LUSC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs9814567 0.752 rs9836401 chr3:134336897 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.12e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg09655341 chr17:79618100 PDE6G -0.28 -6.59 -0.34 1.74e-10 Eye color traits; LUSC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg10053473 chr17:62856997 LRRC37A3 0.64 10.08 0.48 5.06e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8017423 0.967 rs3825662 chr14:90723152 A/G cg14092571 chr14:90743983 NA -0.36 -5.84 -0.3 1.24e-8 Mortality in heart failure; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04564312 chr5:102456179 GIN1 0.39 6.1 0.32 2.89e-9 Triglycerides; LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg08219700 chr8:58056026 NA -0.66 -8.58 -0.42 3.69e-16 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.638 rs12424222 chr12:38548273 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.2 -0.41 5.33e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs477692 0.699 rs509017 chr10:131367174 T/G cg11019008 chr10:131425282 MGMT 0.41 5.96 0.31 6.34e-9 Response to temozolomide; LUSC cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg14829155 chr15:31115871 NA -0.52 -7.22 -0.37 3.48e-12 Huntington's disease progression; LUSC cis rs9457247 0.582 rs9459855 chr6:167466150 G/T cg07741184 chr6:167504864 NA 0.49 8.62 0.43 2.75e-16 Crohn's disease; LUSC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg14668632 chr7:2872130 GNA12 -0.45 -6.21 -0.32 1.59e-9 Height; LUSC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg12463550 chr7:65579703 CRCP 0.42 6.07 0.32 3.45e-9 Calcium levels; LUSC cis rs6674970 1.000 rs6674970 chr1:151116279 C/T cg03258749 chr1:151040405 MLLT11 -0.4 -5.99 -0.31 5.43e-9 Childhood ear infection; LUSC cis rs1577917 1.000 rs13194429 chr6:86646705 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs1865760 0.892 rs9379806 chr6:25940958 G/A cg17691542 chr6:26056736 HIST1H1C 0.49 7.19 0.37 4.26e-12 Height; LUSC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg14552801 chr7:65878734 NA -0.43 -5.87 -0.31 1.04e-8 Aortic root size; LUSC trans rs984440 0.961 rs7813366 chr8:139080406 C/T cg03334052 chr1:168888044 NA 0.42 5.98 0.31 5.68e-9 Obesity-related traits; LUSC cis rs2398893 0.960 rs56335449 chr9:96748795 G/A cg14459158 chr9:96720562 NA 0.32 5.81 0.3 1.44e-8 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1691799 0.899 rs2951656 chr12:66732273 T/G cg16791601 chr12:66731901 HELB -0.73 -12.34 -0.56 4.61e-29 White blood cell count (basophil); LUSC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg22834771 chr12:69754056 YEATS4 -0.56 -8.33 -0.41 2.1e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg06221963 chr1:154839813 KCNN3 -0.6 -13.65 -0.6 5.11e-34 Prostate cancer; LUSC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.69 -0.34 9.49e-11 Alzheimer's disease (late onset); LUSC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg19318889 chr4:1322082 MAEA 0.77 13.46 0.59 2.67e-33 Longevity; LUSC cis rs7927592 0.546 rs497261 chr11:68192244 T/C cg16797656 chr11:68205561 LRP5 0.45 7.81 0.39 7.47e-14 Total body bone mineral density; LUSC cis rs908922 0.676 rs4112786 chr1:152532872 T/A cg20991723 chr1:152506922 NA 0.48 8.81 0.43 7.05e-17 Hair morphology; LUSC cis rs73198271 0.920 rs11781542 chr8:8617181 G/T cg15556689 chr8:8085844 FLJ10661 -0.47 -5.8 -0.3 1.58e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7189233 0.911 rs72801854 chr16:53517242 G/A cg09728985 chr16:53543985 NA -0.35 -6.37 -0.33 6.34e-10 Intelligence (multi-trait analysis); LUSC cis rs7312122 0.557 rs4767008 chr12:113217468 C/T cg00851732 chr12:113229793 RPH3A 0.49 5.74 0.3 2.12e-8 Methotrexate phramacokinetics (acute lymphoblastic leukemia); LUSC cis rs6582630 0.576 rs3900594 chr12:38272429 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.51 -0.42 5.99e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs2354432 0.505 rs72691009 chr1:146708397 C/T cg25205988 chr1:146714368 CHD1L -1.02 -8.96 -0.44 2.35e-17 Mitochondrial DNA levels; LUSC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 7.76 0.39 1.02e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.97 -0.36 1.67e-11 Colorectal cancer; LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.46 -6.21 -0.32 1.55e-9 Renal function-related traits (BUN); LUSC trans rs12885221 0.542 rs7147339 chr14:33275672 T/C cg10551270 chr5:892523 TRIP13;BRD9 -0.4 -6.06 -0.31 3.64e-9 Intelligence (multi-trait analysis); LUSC cis rs35883536 0.647 rs1335765 chr1:101048612 A/T cg06223162 chr1:101003688 GPR88 -0.48 -8.83 -0.44 5.88e-17 Monocyte count; LUSC cis rs7107174 1.000 rs7101429 chr11:77992967 A/G cg02023728 chr11:77925099 USP35 0.49 6.84 0.35 3.83e-11 Testicular germ cell tumor; LUSC trans rs2204008 0.506 rs11495470 chr12:38026904 C/T cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.54e-10 Bladder cancer; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg00166722 chr3:10149974 C3orf24 0.55 7.5 0.38 5.99e-13 Alzheimer's disease; LUSC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg07703079 chr11:430292 ANO9 0.65 6.79 0.35 5.14e-11 Body mass index; LUSC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg02038168 chr22:39784481 NA -0.46 -6.89 -0.35 2.79e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2282300 0.739 rs34224414 chr11:30251041 T/G cg06241208 chr11:30344200 C11orf46 -0.44 -5.65 -0.3 3.52e-8 Morning vs. evening chronotype; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21014120 chr2:203736523 ICA1L -0.42 -6.37 -0.33 6.13e-10 Electrocardiographic conduction measures; LUSC cis rs34638657 0.702 rs35865749 chr16:82199677 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.4 -0.33 5.4e-10 Lung adenocarcinoma; LUSC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.95 -0.4 2.87e-14 Crohn's disease; LUSC trans rs7939886 0.841 rs11231800 chr11:55770930 A/G cg03929089 chr4:120376271 NA 0.79 6.24 0.32 1.32e-9 Myopia (pathological); LUSC cis rs9527 0.622 rs12779263 chr10:104886533 G/T cg04362960 chr10:104952993 NT5C2 0.63 9.85 0.47 2.92e-20 Arsenic metabolism; LUSC cis rs7428 0.962 rs3637 chr2:85549874 A/G cg24342717 chr2:85555507 TGOLN2 -0.6 -8.76 -0.43 1.03e-16 Ear protrusion; LUSC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg00908189 chr16:619842 PIGQ 0.66 10.27 0.49 1.14e-21 Height; LUSC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.9 0.78 1.85e-70 Height; LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg07507251 chr3:52567010 NT5DC2 0.31 6.0 0.31 5.28e-9 Bipolar disorder; LUSC cis rs7953508 0.506 rs10777530 chr12:93961110 C/T cg18151635 chr12:93972918 NA -0.6 -8.66 -0.43 1.99e-16 Pubertal anthropometrics; LUSC cis rs6570726 0.967 rs9497316 chr6:145792387 G/T cg05347473 chr6:146136440 FBXO30 -0.37 -6.24 -0.32 1.3e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg11366901 chr6:160182831 ACAT2 0.91 12.24 0.56 1.04e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs3812831 0.695 rs10467349 chr13:114939441 A/G cg08824895 chr13:115047677 UPF3A 0.55 8.35 0.42 1.84e-15 Schizophrenia; LUSC cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg04586622 chr2:25135609 ADCY3 0.43 9.23 0.45 3.12e-18 Body mass index; LUSC cis rs5769707 0.667 rs4824069 chr22:50030325 T/C cg10356904 chr22:49881777 NA -0.29 -5.8 -0.3 1.55e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg24209194 chr3:40518798 ZNF619 0.47 6.35 0.33 7.15e-10 Renal cell carcinoma; LUSC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg03806693 chr22:41940476 POLR3H -1.04 -14.65 -0.63 7.01e-38 Vitiligo; LUSC cis rs2200578 0.732 rs56271621 chr2:99658200 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.56 6.53 0.34 2.5e-10 IgG glycosylation; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05999005 chr2:152685246 ARL5A -0.43 -6.63 -0.34 1.37e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.64 0.39 2.25e-13 Parkinson's disease; LUSC cis rs3782089 1.000 rs3782089 chr11:65336819 C/T cg00206168 chr11:65308501 LTBP3 1.16 8.45 0.42 9.36e-16 Height; LUSC cis rs11577318 0.853 rs4526602 chr1:26648034 C/T cg00852783 chr1:26633632 UBXN11 0.6 8.92 0.44 3.24e-17 Granulocyte percentage of myeloid white cells; LUSC cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg08999081 chr20:33150536 PIGU -0.53 -10.48 -0.5 2.07e-22 Glomerular filtration rate (creatinine); LUSC cis rs28829049 0.597 rs12740975 chr1:19437923 G/A cg13387374 chr1:19411106 UBR4 0.42 5.78 0.3 1.71e-8 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.49 -6.79 -0.35 5e-11 Tonsillectomy; LUSC cis rs2430307 0.556 rs3905501 chr7:76542080 C/T cg15770687 chr7:76625569 PMS2L11 -0.77 -8.51 -0.42 5.79e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC trans rs1814175 0.935 rs11040463 chr11:49685574 C/T cg15704280 chr7:45808275 SEPT13 -1.08 -21.97 -0.77 8.05e-67 Height; LUSC cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.71 0.51 3.28e-23 Bladder cancer; LUSC cis rs3126085 0.935 rs10888468 chr1:152181539 C/T cg26876637 chr1:152193138 HRNR 0.42 5.89 0.31 9.39e-9 Atopic dermatitis; LUSC cis rs662735 0.515 rs686901 chr11:30854334 C/G cg14844989 chr11:31128820 NA 0.38 6.08 0.32 3.34e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs7647973 1.000 rs3448 chr3:49396751 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.46 6.99 0.36 1.53e-11 Menarche (age at onset); LUSC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg22433210 chr17:43662623 NA 0.76 10.84 0.51 1.12e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg13072238 chr3:49761600 GMPPB -0.71 -8.92 -0.44 3.03e-17 Menarche (age at onset); LUSC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.25 0.49 1.34e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7949030 0.780 rs3017666 chr11:62404417 A/T cg13298116 chr11:62369859 EML3;MTA2 -0.51 -8.73 -0.43 1.21e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg10018233 chr7:150070692 REPIN1 0.37 6.54 0.34 2.35e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs6545883 0.772 rs1186709 chr2:61689380 G/A cg15711740 chr2:61764176 XPO1 -0.44 -6.72 -0.34 8.05e-11 Tuberculosis; LUSC cis rs11098499 0.661 rs10015965 chr4:120268237 A/G cg24375607 chr4:120327624 NA 0.69 10.99 0.52 3.39e-24 Corneal astigmatism; LUSC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg18357526 chr6:26021779 HIST1H4A -0.41 -6.41 -0.33 4.95e-10 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.12 -0.36 6.84e-12 Major depressive disorder; LUSC cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg05855489 chr10:104503620 C10orf26 0.6 9.79 0.47 4.58e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2274273 0.840 rs6573014 chr14:55735892 C/T cg04306507 chr14:55594613 LGALS3 -0.57 -13.26 -0.59 1.6e-32 Protein biomarker; LUSC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.46 0.53 7.42e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 1.000 rs12424741 chr12:34022771 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.7 -0.39 1.51e-13 Morning vs. evening chronotype; LUSC cis rs7582720 1.000 rs72932786 chr2:203698737 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg27494647 chr7:150038898 RARRES2 0.47 7.21 0.37 3.88e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs8060686 0.641 rs118035472 chr16:68242311 A/G cg27539214 chr16:67997921 SLC12A4 -0.56 -7.23 -0.37 3.42e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs6692729 0.966 rs6688068 chr1:227010730 A/T cg10327440 chr1:227177885 CDC42BPA 0.48 6.9 0.35 2.63e-11 Electrodermal activity; LUSC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg11764359 chr7:65958608 NA 0.64 9.73 0.47 7.11e-20 Aortic root size; LUSC cis rs9486719 0.522 rs4839683 chr6:96851933 A/G cg06623918 chr6:96969491 KIAA0776 0.72 9.7 0.47 9.32e-20 Migraine;Coronary artery disease; LUSC cis rs7584330 0.744 rs72620822 chr2:238379582 C/T cg14458575 chr2:238380390 NA 0.88 15.56 0.65 2.02e-41 Prostate cancer; LUSC cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg27129171 chr3:47204927 SETD2 0.69 11.54 0.53 3.8e-26 Colorectal cancer; LUSC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg02117656 chr17:79614917 TSPAN10 0.31 5.81 0.3 1.42e-8 Eye color traits; LUSC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg15445000 chr17:37608096 MED1 0.4 6.78 0.35 5.36e-11 Glomerular filtration rate (creatinine); LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg02018176 chr4:1364513 KIAA1530 -0.5 -8.6 -0.43 3.07e-16 Obesity-related traits; LUSC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs899997 0.862 rs11072787 chr15:78972977 T/C cg04896959 chr15:78267971 NA -0.46 -9.09 -0.45 9.1e-18 Coronary artery disease or large artery stroke; LUSC cis rs4629180 1.000 rs974374 chr2:102105846 C/T cg01388757 chr2:102091195 RFX8 0.47 7.64 0.39 2.26e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -7.08 -0.36 8.73e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2279817 0.818 rs34304724 chr1:17994850 C/T cg21791023 chr1:18019539 ARHGEF10L -0.48 -5.92 -0.31 7.81e-9 Neuroticism; LUSC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg22535103 chr8:58192502 C8orf71 -0.84 -8.32 -0.41 2.27e-15 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg18876405 chr7:65276391 NA -0.57 -9.33 -0.45 1.48e-18 Aortic root size; LUSC cis rs77633900 0.772 rs283802 chr15:76791270 C/T cg21673338 chr15:77095150 SCAPER -0.71 -6.03 -0.31 4.33e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs983392 0.679 rs655231 chr11:60013857 A/G cg20284999 chr11:59952153 MS4A6A -0.37 -6.34 -0.33 7.63e-10 Alzheimer's disease (late onset); LUSC cis rs4343996 0.837 rs6462105 chr7:3514512 C/T cg21248987 chr7:3385318 SDK1 0.35 5.77 0.3 1.82e-8 Motion sickness; LUSC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg17724175 chr1:150552817 MCL1 0.37 6.65 0.34 1.23e-10 Tonsillectomy; LUSC cis rs9815354 0.812 rs73071341 chr3:41826211 C/T cg03022575 chr3:42003672 ULK4 0.85 8.57 0.42 3.99e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg06873352 chr17:61820015 STRADA 0.71 12.79 0.57 9.37e-31 Prudent dietary pattern; LUSC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg00149659 chr3:10157352 C3orf10 1.0 14.6 0.62 1.11e-37 Alzheimer's disease; LUSC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC trans rs6598955 0.585 rs12138111 chr1:26590432 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs4700695 0.668 rs253212 chr5:65497553 C/T cg21114390 chr5:65439923 SFRS12 -0.5 -6.96 -0.36 1.81e-11 Facial morphology (factor 19); LUSC cis rs7408868 1.000 rs10415431 chr19:15277027 G/A cg14696996 chr19:15285081 NOTCH3 0.99 9.07 0.44 1.06e-17 Pulse pressure; LUSC trans rs6445975 0.572 rs12485999 chr3:58409763 C/T cg18950693 chr14:70346909 SMOC1 -0.39 -5.96 -0.31 6.27e-9 Systemic lupus erythematosus; LUSC cis rs62400317 0.723 rs12196188 chr6:44976426 G/C cg18551225 chr6:44695536 NA -0.43 -6.89 -0.35 2.83e-11 Total body bone mineral density; LUSC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg27494647 chr7:150038898 RARRES2 0.57 8.36 0.42 1.67e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC cis rs10823500 0.748 rs2394668 chr10:71943951 G/A cg02100629 chr10:71892760 AIFM2 -0.4 -6.44 -0.33 4.16e-10 Blood protein levels; LUSC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.47 7.46 0.38 7.33e-13 Menarche (age at onset); LUSC trans rs2048656 0.600 rs1976671 chr8:9679634 A/G cg15556689 chr8:8085844 FLJ10661 0.47 6.7 0.34 8.61e-11 Schizophrenia; LUSC cis rs12760731 0.720 rs10753178 chr1:178401000 A/T cg00404053 chr1:178313656 RASAL2 0.54 6.23 0.32 1.38e-9 Obesity-related traits; LUSC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg17366294 chr4:99064904 C4orf37 0.56 9.84 0.47 3.25e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10572969 chr11:13690188 FAR1 0.72 5.94 0.31 7.06e-9 Cognitive performance; LUSC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg06074448 chr4:187884817 NA 0.45 7.33 0.37 1.73e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg06558623 chr16:89946397 TCF25 -0.96 -10.21 -0.49 1.79e-21 Skin colour saturation; LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg05717871 chr11:638507 DRD4 -0.34 -5.9 -0.31 8.74e-9 Systemic lupus erythematosus; LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg00684032 chr4:1343700 KIAA1530 0.35 6.36 0.33 6.77e-10 Obesity-related traits; LUSC cis rs12594515 1.000 rs12911309 chr15:45985719 G/C cg06207120 chr15:45996521 NA 0.39 5.9 0.31 8.8e-9 Waist circumference;Weight; LUSC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg20406979 chr6:167373233 NA -0.25 -6.02 -0.31 4.58e-9 Crohn's disease; LUSC trans rs57046232 0.552 rs6054166 chr20:6348251 A/C cg21095983 chr6:86352623 SYNCRIP 0.48 7.18 0.37 4.67e-12 Colorectal cancer; LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.07 0.36 9.17e-12 Platelet count; LUSC cis rs17286411 0.750 rs35619990 chr16:71949266 C/T cg03805757 chr16:71968109 PKD1L3 0.42 6.96 0.36 1.83e-11 Blood protein levels; LUSC cis rs6546886 0.912 rs60279245 chr2:74312743 T/G cg14702570 chr2:74259524 NA -0.3 -5.73 -0.3 2.2e-8 Dialysis-related mortality; LUSC trans rs2727020 0.754 rs10839226 chr11:49150883 C/G cg15704280 chr7:45808275 SEPT13 -0.5 -6.88 -0.35 2.99e-11 Coronary artery disease; LUSC cis rs9393692 0.676 rs1543681 chr6:26187783 G/T cg00631329 chr6:26305371 NA -0.38 -7.28 -0.37 2.42e-12 Educational attainment; LUSC cis rs6964587 1.000 rs4644173 chr7:91759597 A/G cg17063962 chr7:91808500 NA 0.58 9.24 0.45 2.89e-18 Breast cancer; LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.9 -11.41 -0.53 1.12e-25 Gut microbiome composition (summer); LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.51 -0.5 1.61e-22 Alzheimer's disease; LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg07395648 chr5:131743802 NA -0.4 -5.96 -0.31 6.36e-9 Breast cancer; LUSC cis rs6459788 0.585 rs6950818 chr7:157235364 C/G cg03453431 chr7:157225567 NA -0.63 -11.72 -0.54 8.31e-27 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs11122272 0.735 rs2295420 chr1:231485640 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.67 -10.43 -0.5 3.17e-22 Hemoglobin concentration; LUSC cis rs2354432 0.607 rs7523812 chr1:146673489 A/G cg25205988 chr1:146714368 CHD1L -1.05 -8.61 -0.43 2.87e-16 Mitochondrial DNA levels; LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.43 7.43 0.38 9.47e-13 Electroencephalogram traits; LUSC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg16405210 chr4:1374714 KIAA1530 -0.57 -8.77 -0.43 8.98e-17 Obesity-related traits; LUSC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg06484146 chr7:12443880 VWDE -0.67 -6.93 -0.35 2.12e-11 Coronary artery disease; LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg10729496 chr3:10149963 C3orf24 0.58 7.74 0.39 1.23e-13 Alzheimer's disease; LUSC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg06618935 chr21:46677482 NA -0.37 -7.33 -0.37 1.75e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.88 0.31 9.93e-9 Rheumatoid arthritis; LUSC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg18099408 chr3:52552593 STAB1 -0.4 -7.03 -0.36 1.18e-11 Electroencephalogram traits; LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 13.83 0.6 1.06e-34 Platelet count; LUSC cis rs612683 0.862 rs12760924 chr1:100898600 A/T cg06223162 chr1:101003688 GPR88 0.44 7.85 0.39 5.53e-14 Breast cancer; LUSC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg09365446 chr1:150670422 GOLPH3L 0.49 7.04 0.36 1.09e-11 Melanoma; LUSC trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg15704280 chr7:45808275 SEPT13 0.93 13.42 0.59 3.9e-33 Coronary artery disease; LUSC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg10802521 chr3:52805072 NEK4 -0.56 -8.98 -0.44 2e-17 Bipolar disorder; LUSC cis rs8113142 0.614 rs4805261 chr19:29213292 T/C cg04546413 chr19:29218101 NA 0.46 6.25 0.32 1.26e-9 Femoral neck bone geometry and menarche (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02771843 chr3:69062953 C3orf64 -0.5 -6.17 -0.32 2.03e-9 Bipolar disorder and schizophrenia; LUSC cis rs17095355 1.000 rs11194922 chr10:111695656 G/T cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.96 -0.36 1.81e-11 Biliary atresia; LUSC cis rs12900413 0.603 rs12906832 chr15:90301314 C/G cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs459571 0.959 rs2810491 chr9:136923331 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 0.42 6.0 0.31 5.18e-9 Platelet distribution width; LUSC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg09365446 chr1:150670422 GOLPH3L 0.45 6.59 0.34 1.66e-10 Melanoma; LUSC cis rs2839186 0.872 rs13052233 chr21:47707284 G/T cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs500891 0.810 rs3812143 chr6:84141282 G/C cg08257003 chr6:84140564 ME1 0.35 7.27 0.37 2.56e-12 Platelet-derived growth factor BB levels; LUSC cis rs694739 0.654 rs10897488 chr11:64140806 T/C cg02228329 chr11:64053129 BAD;GPR137 0.44 6.25 0.32 1.26e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg18252515 chr7:66147081 NA -1.23 -13.29 -0.59 1.17e-32 Diabetic kidney disease; LUSC cis rs2667011 0.818 rs7590560 chr2:160843043 C/G cg06573604 chr2:160760825 LY75 0.49 6.19 0.32 1.77e-9 Bilirubin levels; LUSC cis rs1371867 0.846 rs1660338 chr8:101242757 C/G cg06002616 chr8:101225028 SPAG1 -0.4 -6.57 -0.34 1.93e-10 Atrioventricular conduction; LUSC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg04166393 chr7:2884313 GNA12 0.43 5.76 0.3 1.94e-8 Height; LUSC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg00990874 chr7:1149470 C7orf50 -0.53 -6.5 -0.34 2.94e-10 Bronchopulmonary dysplasia; LUSC cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.25 0.37 2.91e-12 Motion sickness; LUSC cis rs11650494 0.908 rs118099826 chr17:47447836 G/T cg08112188 chr17:47440006 ZNF652 1.38 11.35 0.53 1.79e-25 Prostate cancer; LUSC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -7.41 -0.38 1.03e-12 Developmental language disorder (linguistic errors); LUSC cis rs72781680 0.898 rs72798064 chr2:23982832 T/C cg08917208 chr2:24149416 ATAD2B 0.87 9.64 0.47 1.41e-19 Lymphocyte counts; LUSC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.08 -0.32 3.26e-9 Major depressive disorder; LUSC cis rs7575217 0.588 rs11675221 chr2:101670937 C/T cg23907051 chr2:101730305 TBC1D8 0.27 6.62 0.34 1.44e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.25 0.32 1.25e-9 Platelet count; LUSC cis rs9356171 0.572 rs2281406 chr6:164325848 C/T cg25752492 chr6:164341247 NA -0.38 -6.6 -0.34 1.64e-10 Diisocyanate-induced asthma; LUSC cis rs11971779 0.752 rs4732371 chr7:139077317 T/A cg07862535 chr7:139043722 LUC7L2 0.59 7.31 0.37 2.01e-12 Diisocyanate-induced asthma; LUSC cis rs2580764 0.573 rs13387751 chr2:55227375 C/G cg20993754 chr2:55226987 RTN4 0.34 5.69 0.3 2.82e-8 Mean platelet volume; LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg16325326 chr1:53192061 ZYG11B -0.89 -16.3 -0.67 2.24e-44 Monocyte count; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg26304593 chr6:42947056 PEX6 -0.54 -8.49 -0.42 6.8e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.73 0.35 7.22e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.27 0.37 2.54e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19826802 chr17:26972212 KIAA0100 0.65 6.03 0.31 4.42e-9 Cognitive performance; LUSC trans rs9291683 0.679 rs3756225 chr4:10094133 G/C cg26043149 chr18:55253948 FECH -0.54 -8.17 -0.41 6.46e-15 Bone mineral density; LUSC cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg09184832 chr6:79620586 NA -0.45 -7.43 -0.38 9.27e-13 Intelligence (multi-trait analysis); LUSC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg18904891 chr8:8559673 CLDN23 0.61 8.47 0.42 7.74e-16 Obesity-related traits; LUSC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg00012203 chr2:219082015 ARPC2 -0.69 -11.35 -0.53 1.78e-25 Colorectal cancer; LUSC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.33 0.33 8.03e-10 Mean platelet volume; LUSC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg26380479 chr7:97908229 NA -0.27 -6.04 -0.31 4.09e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4144743 0.877 rs7218773 chr17:45324211 C/T cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg13531842 chr10:38383804 ZNF37A -0.45 -7.08 -0.36 8.53e-12 Extrinsic epigenetic age acceleration; LUSC trans rs7647973 0.710 rs34890793 chr3:49619493 C/T cg21659725 chr3:3221576 CRBN -0.71 -8.18 -0.41 5.86e-15 Menarche (age at onset); LUSC cis rs524023 1.000 rs10897518 chr11:64360705 A/G cg07220939 chr11:64358617 SLC22A12 0.22 5.74 0.3 2.12e-8 Urate levels in obese individuals; LUSC cis rs4356932 1.000 rs4543147 chr4:76976661 A/G cg00809888 chr4:76862425 NAAA 0.36 5.95 0.31 6.91e-9 Blood protein levels; LUSC cis rs10782582 0.593 rs2147039 chr1:76143166 C/T cg10523679 chr1:76189770 ACADM -0.5 -7.31 -0.37 2.01e-12 Daytime sleep phenotypes; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs734999 0.545 rs28532547 chr1:2561286 T/G cg18854424 chr1:2615690 NA -0.49 -9.97 -0.48 1.18e-20 Ulcerative colitis; LUSC cis rs2853333 0.622 rs2519962 chr19:35752691 A/G cg12287945 chr19:35758300 LSR -0.39 -5.7 -0.3 2.66e-8 Red blood cell count; LUSC cis rs7769051 0.522 rs10457596 chr6:133169974 T/G cg22852734 chr6:133119734 C6orf192 0.83 6.71 0.34 8.22e-11 Type 2 diabetes nephropathy; LUSC cis rs4423214 1.000 rs11600860 chr11:71164019 T/C cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg04944784 chr2:26401820 FAM59B -0.48 -6.33 -0.33 7.96e-10 Gut microbiome composition (summer); LUSC trans rs7939886 0.920 rs11227638 chr11:56019585 A/T cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg02773041 chr1:40204384 PPIE 0.55 8.26 0.41 3.47e-15 Blood protein levels; LUSC cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg06784218 chr1:46089804 CCDC17 -0.48 -9.31 -0.45 1.76e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 9.91e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.61 -7.75 -0.39 1.12e-13 Glomerular filtration rate in chronic kidney disease; LUSC cis rs8078723 0.966 rs57968500 chr17:38145828 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.77 -0.35 5.94e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7605827 0.930 rs12993042 chr2:15708218 A/T cg19274914 chr2:15703543 NA 0.44 8.36 0.42 1.71e-15 Educational attainment (years of education); LUSC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg12963246 chr6:28129442 ZNF389 0.48 6.55 0.34 2.12e-10 Depression; LUSC trans rs7944735 1.000 rs7944735 chr11:47955608 G/C cg03929089 chr4:120376271 NA 0.61 6.31 0.33 8.84e-10 Intraocular pressure; LUSC cis rs11039100 1.000 rs1470872 chr11:5827540 T/C cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.47 6.85 0.35 3.64e-11 Eosinophil percentage of white cells; LUSC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.17 15.85 0.66 1.37e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg18681998 chr4:17616180 MED28 0.85 15.99 0.66 3.99e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11122272 0.735 rs10489610 chr1:231517765 C/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC trans rs34421088 0.506 rs2572428 chr8:11146672 T/A cg15556689 chr8:8085844 FLJ10661 0.46 6.96 0.36 1.79e-11 Neuroticism; LUSC cis rs7829975 0.582 rs6982832 chr8:8792217 A/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.71 -0.34 8.56e-11 Mood instability; LUSC cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg19052272 chr2:3704530 ALLC 0.46 8.03 0.4 1.73e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg14893161 chr1:205819251 PM20D1 0.94 18.91 0.72 9.99e-55 Menarche (age at onset); LUSC cis rs9341808 0.652 rs2505940 chr6:80851191 T/C cg08355045 chr6:80787529 NA 0.47 8.07 0.4 1.24e-14 Sitting height ratio; LUSC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg17179660 chr6:151773299 C6orf211;RMND1 -0.58 -8.42 -0.42 1.14e-15 Menarche (age at onset); LUSC cis rs11662586 0.517 rs11662894 chr18:77713591 G/A cg20368463 chr18:77673604 PQLC1 0.76 12.74 0.57 1.46e-30 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs7659604 0.605 rs67772833 chr4:122723106 G/A cg19748678 chr4:122722346 EXOSC9 0.6 9.06 0.44 1.08e-17 Type 2 diabetes; LUSC cis rs7267979 1.000 rs2257982 chr20:25269630 A/G cg08601574 chr20:25228251 PYGB 0.43 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs2262909 1.000 rs765527 chr19:22129555 A/G cg17074339 chr11:11642133 GALNTL4 0.4 6.07 0.32 3.49e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs17030434 0.953 rs6535953 chr4:154728186 G/A cg14289246 chr4:154710475 SFRP2 -0.51 -6.75 -0.35 6.73e-11 Electrocardiographic conduction measures; LUSC cis rs6456156 0.586 rs13208636 chr6:167461965 T/G cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs10761750 1 rs10761750 chr10:65128619 G/A cg01631684 chr10:65280961 REEP3 -0.4 -6.17 -0.32 1.96e-9 Vascular endothelial growth factor levels; LUSC cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg12310025 chr6:25882481 NA -0.5 -8.97 -0.44 2.17e-17 Blood metabolite levels; LUSC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.24 0.52 4.53e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg26380479 chr7:97908229 NA -0.27 -6.11 -0.32 2.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9790314 0.765 rs4856768 chr3:161004392 G/A cg03342759 chr3:160939853 NMD3 -0.56 -9.52 -0.46 3.51e-19 Morning vs. evening chronotype; LUSC cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg10224037 chr5:178157518 ZNF354A 0.57 7.18 0.37 4.51e-12 Neutrophil percentage of white cells; LUSC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg16339924 chr4:17578868 LAP3 0.58 8.8 0.43 7.66e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs709400 0.628 rs2273700 chr14:103923414 A/G cg24130564 chr14:104152367 KLC1 -0.45 -6.36 -0.33 6.5e-10 Body mass index; LUSC cis rs7592578 0.882 rs2192010 chr2:191462133 C/T cg10560079 chr2:191398806 TMEM194B -0.7 -8.8 -0.43 7.45e-17 Diastolic blood pressure; LUSC cis rs8016982 0.662 rs7144005 chr14:81656437 C/T cg01989461 chr14:81687754 GTF2A1 0.52 6.8 0.35 4.89e-11 Schizophrenia; LUSC cis rs7089973 0.604 rs11196941 chr10:116596258 A/G cg25233709 chr10:116636983 FAM160B1 0.36 6.41 0.33 4.9e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2282802 0.651 rs6863474 chr5:139630862 C/T cg26211634 chr5:139558579 C5orf32 0.44 8.22 0.41 4.71e-15 Intelligence (multi-trait analysis); LUSC trans rs45509595 0.841 rs17751184 chr6:27775028 C/T cg01620082 chr3:125678407 NA -0.82 -7.24 -0.37 3.06e-12 Breast cancer; LUSC cis rs2836633 0.894 rs55955614 chr21:40037330 T/G cg05519781 chr21:40033154 ERG 0.77 13.35 0.59 7.23e-33 Coronary artery disease; LUSC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC trans rs7395662 0.611 rs7478698 chr11:48549139 T/C cg03929089 chr4:120376271 NA -0.44 -6.11 -0.32 2.7e-9 HDL cholesterol; LUSC cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg07606381 chr6:8435919 SLC35B3 0.74 12.5 0.56 1.1e-29 Motion sickness; LUSC cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg15556689 chr8:8085844 FLJ10661 -0.62 -9.65 -0.47 1.36e-19 Mood instability; LUSC cis rs12220238 1.000 rs7081350 chr10:75990328 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.79 0.35 5.26e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.55 -8.63 -0.43 2.49e-16 Personality dimensions; LUSC cis rs131777 0.577 rs5770928 chr22:51029091 G/C cg25575065 chr22:51066394 ARSA -0.44 -6.07 -0.32 3.56e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7772486 0.806 rs2265477 chr6:146212338 T/C cg05347473 chr6:146136440 FBXO30 0.48 8.2 0.41 5.16e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs8099014 0.814 rs9966765 chr18:56116790 C/G cg12907477 chr18:56117327 MIR122 0.43 6.67 0.34 1.05e-10 Platelet count; LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg27170947 chr2:26402098 FAM59B -0.69 -10.39 -0.49 4.13e-22 Gut microbiome composition (summer); LUSC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg06850241 chr22:41845214 NA 0.34 6.3 0.33 9.47e-10 Vitiligo; LUSC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg21972741 chr5:435613 AHRR 0.37 6.99 0.36 1.47e-11 Cystic fibrosis severity; LUSC trans rs3960554 0.932 rs11971220 chr7:75842792 C/T cg19862616 chr7:65841803 NCRNA00174 0.89 9.56 0.46 2.71e-19 Eotaxin levels; LUSC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg00343986 chr7:65444356 GUSB -0.38 -5.73 -0.3 2.29e-8 Aortic root size; LUSC cis rs12908161 1.000 rs35726233 chr15:85337800 C/T cg17173187 chr15:85201210 NMB 0.48 8.9 0.44 3.51e-17 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25444017 chr11:93475004 TAF1D;C11orf54 0.42 6.33 0.33 7.71e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7100689 0.646 rs1538819 chr10:82122523 A/G cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs765787 0.530 rs12904331 chr15:45518293 C/T cg24006582 chr15:45444508 DUOX1 0.66 9.55 0.46 2.95e-19 Uric acid levels; LUSC trans rs11039798 0.582 rs1483119 chr11:48382334 A/G cg15704280 chr7:45808275 SEPT13 -0.66 -7.12 -0.36 6.71e-12 Axial length; LUSC cis rs61931739 0.534 rs4547187 chr12:34041259 T/C cg06521331 chr12:34319734 NA -0.49 -8.19 -0.41 5.73e-15 Morning vs. evening chronotype; LUSC cis rs1008375 0.898 rs9998130 chr4:17593905 A/G cg16339924 chr4:17578868 LAP3 0.71 11.34 0.53 2.02e-25 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11105298 0.891 rs10858894 chr12:89914261 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.39 -0.38 1.15e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs35306767 0.669 rs2101051 chr10:1158791 G/T cg20503657 chr10:835505 NA 0.57 6.77 0.35 5.64e-11 Eosinophil percentage of granulocytes; LUSC cis rs2832077 0.943 rs2832097 chr21:30173340 A/T cg08807101 chr21:30365312 RNF160 0.51 6.64 0.34 1.25e-10 Cognitive test performance; LUSC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.67 0.39 1.9e-13 Parkinson's disease; LUSC cis rs10193935 0.901 rs6752455 chr2:42543577 A/C cg27598129 chr2:42591480 NA -0.61 -8.52 -0.42 5.73e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg22535103 chr8:58192502 C8orf71 -0.63 -7.08 -0.36 8.33e-12 Developmental language disorder (linguistic errors); LUSC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg09323728 chr8:95962352 TP53INP1 -0.39 -7.79 -0.39 8.44e-14 Type 2 diabetes; LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg05025164 chr4:1340916 KIAA1530 0.43 6.65 0.34 1.22e-10 Obesity-related traits; LUSC cis rs896543 0.702 rs6711119 chr2:237494334 C/T cg25295825 chr2:237489920 CXCR7 0.52 6.36 0.33 6.67e-10 Alcohol dependence (age at onset); LUSC cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.77 7.65 0.39 2.1e-13 Initial pursuit acceleration; LUSC trans rs11098499 0.908 rs28559989 chr4:120386627 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.21e-9 Corneal astigmatism; LUSC cis rs1559088 0.948 rs7257858 chr19:33591231 T/C cg17764715 chr19:33622953 WDR88 0.6 8.23 0.41 4.15e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg24675658 chr1:53192096 ZYG11B 0.76 13.05 0.58 9.97e-32 Monocyte count; LUSC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg17948913 chr5:572064 NA 0.38 6.29 0.33 9.68e-10 Obesity-related traits; LUSC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg05347473 chr6:146136440 FBXO30 -0.47 -7.97 -0.4 2.54e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2980439 0.557 rs2921056 chr8:8319182 T/C cg06636001 chr8:8085503 FLJ10661 0.67 10.87 0.51 8.91e-24 Neuroticism; LUSC trans rs4596713 0.568 rs7038833 chr9:71748097 C/T cg25283916 chr1:242222868 NA -0.32 -6.71 -0.34 8.25e-11 Headache; LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg13395646 chr4:1353034 KIAA1530 -0.59 -9.19 -0.45 4.14e-18 Obesity-related traits; LUSC cis rs6692729 0.933 rs2855560 chr1:227081028 A/C cg10327440 chr1:227177885 CDC42BPA -0.5 -7.09 -0.36 7.94e-12 Electrodermal activity; LUSC cis rs8072100 0.764 rs4794371 chr17:45627693 G/C cg19784903 chr17:45786737 TBKBP1 0.37 5.7 0.3 2.6e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7568458 0.684 rs60012532 chr2:85752474 A/C cg17127132 chr2:85788382 GGCX 0.43 6.21 0.32 1.56e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg25703541 chr22:24373054 LOC391322 -0.62 -7.82 -0.39 6.84e-14 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs4631830 0.863 rs2611489 chr10:51524889 C/T cg16070123 chr10:51489643 NA -0.52 -8.4 -0.42 1.27e-15 Prostate-specific antigen levels; LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg13395646 chr4:1353034 KIAA1530 -0.57 -8.87 -0.44 4.58e-17 Obesity-related traits; LUSC cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg13010199 chr12:38710504 ALG10B 0.69 11.46 0.53 7.01e-26 Heart rate; LUSC trans rs853679 1.000 rs1679709 chr6:28228342 A/G cg06606381 chr12:133084897 FBRSL1 0.57 6.49 0.33 3.17e-10 Depression; LUSC trans rs61931739 0.591 rs10743834 chr12:33916129 A/C cg26384229 chr12:38710491 ALG10B 0.52 7.77 0.39 9.66e-14 Morning vs. evening chronotype; LUSC cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -7.03 -0.36 1.19e-11 Monocyte percentage of white cells; LUSC cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.74 -0.51 2.59e-23 Chronic sinus infection; LUSC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.13e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg23262073 chr20:60523788 NA -0.44 -6.23 -0.32 1.4e-9 Body mass index; LUSC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg08439880 chr3:133502540 NA 0.35 6.46 0.33 3.61e-10 Iron status biomarkers; LUSC trans rs61931739 0.621 rs843785 chr12:33729308 C/T cg26384229 chr12:38710491 ALG10B -0.42 -6.06 -0.31 3.59e-9 Morning vs. evening chronotype; LUSC cis rs12681288 0.676 rs2701927 chr8:995886 G/A cg15309053 chr8:964076 NA 0.4 8.11 0.41 9.83e-15 Schizophrenia; LUSC cis rs865483 0.895 rs6607275 chr17:35833208 T/C cg06716730 chr17:35851459 DUSP14 0.28 6.18 0.32 1.91e-9 Monocyte count; LUSC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg03806693 chr22:41940476 POLR3H 1.01 13.99 0.61 2.56e-35 Cannabis dependence symptom count; LUSC cis rs9322817 0.691 rs4946648 chr6:105329422 G/T cg02098413 chr6:105308735 HACE1 0.27 5.8 0.3 1.52e-8 Thyroid stimulating hormone; LUSC cis rs926938 0.560 rs360610 chr1:115393915 T/C cg12756093 chr1:115239321 AMPD1 0.53 8.12 0.41 9.04e-15 Autism; LUSC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg21238619 chr17:78079768 GAA -0.38 -7.39 -0.37 1.21e-12 Yeast infection; LUSC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg16624210 chr5:671434 TPPP 0.45 6.09 0.32 3.17e-9 Obesity-related traits; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03172651 chr20:13201655 ISM1 0.4 6.21 0.32 1.55e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg05623727 chr3:50126028 RBM5 -0.32 -5.98 -0.31 5.87e-9 Intelligence (multi-trait analysis); LUSC cis rs10754283 0.967 rs1953821 chr1:90107098 C/G cg21401794 chr1:90099060 LRRC8C 0.63 8.91 0.44 3.47e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg11645453 chr3:52864694 ITIH4 0.34 8.09 0.4 1.13e-14 Bipolar disorder; LUSC trans rs1922233 1.000 rs6851215 chr4:92377632 T/C cg24250684 chr1:219729030 NA -0.34 -6.26 -0.32 1.19e-9 Gut microbiome composition (summer and winter); LUSC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.56 11.98 0.55 9.47e-28 Hemoglobin concentration; LUSC cis rs2404602 0.692 rs66866130 chr15:77128574 T/C cg22467129 chr15:76604101 ETFA -0.44 -6.97 -0.36 1.71e-11 Blood metabolite levels; LUSC cis rs12618769 0.625 rs17034241 chr2:99224998 C/G cg10123293 chr2:99228465 UNC50 0.47 7.71 0.39 1.48e-13 Bipolar disorder; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.15e-9 Prudent dietary pattern; LUSC cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg24642439 chr20:33292090 TP53INP2 0.47 7.17 0.37 4.84e-12 Glomerular filtration rate (creatinine); LUSC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg08645402 chr16:4508243 NA 0.5 8.06 0.4 1.37e-14 Schizophrenia; LUSC cis rs11155671 0.517 rs9397058 chr6:150207249 C/T cg04369109 chr6:150039330 LATS1 -0.4 -5.78 -0.3 1.67e-8 Testicular germ cell tumor; LUSC cis rs17539620 0.624 rs117591255 chr6:154839118 G/A cg20019720 chr6:154832845 CNKSR3 0.63 8.79 0.43 8.09e-17 Lipoprotein (a) levels; LUSC trans rs561341 0.714 rs7218466 chr17:30263314 A/G cg27661571 chr11:113659931 NA -0.56 -6.61 -0.34 1.52e-10 Hip circumference adjusted for BMI; LUSC trans rs9944715 1.000 rs8099202 chr18:43834634 G/T cg01718231 chr17:29326311 RNF135 0.52 7.44 0.38 8.81e-13 Red cell distribution width;Mean corpuscular volume; LUSC trans rs7824557 0.836 rs765731 chr8:11121498 T/A cg15556689 chr8:8085844 FLJ10661 -0.56 -8.61 -0.43 2.92e-16 Retinal vascular caliber; LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg25258033 chr6:167368657 RNASET2 0.39 6.3 0.33 9.49e-10 Crohn's disease; LUSC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg13393036 chr8:95962371 TP53INP1 -0.46 -9.57 -0.46 2.49e-19 Type 2 diabetes; LUSC cis rs1784581 0.599 rs1789992 chr6:162401854 A/G cg17173639 chr6:162384350 PARK2 -0.66 -11.67 -0.54 1.25e-26 Itch intensity from mosquito bite; LUSC cis rs4304924 0.500 rs2281856 chr13:79207644 C/T cg04613313 chr13:79183823 NA 0.42 6.2 0.32 1.7e-9 Large artery stroke; LUSC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg13319975 chr6:146136371 FBXO30 -0.53 -7.94 -0.4 3.06e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg16624210 chr5:671434 TPPP 0.5 6.38 0.33 6.07e-10 Obesity-related traits; LUSC cis rs75229567 0.618 rs11177819 chr12:70134836 T/G cg10114359 chr12:70132523 RAB3IP 1.28 11.11 0.52 1.31e-24 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.73 0.35 7.6e-11 Hip circumference adjusted for BMI; LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg05025164 chr4:1340916 KIAA1530 -0.63 -9.89 -0.48 2.2e-20 Obesity-related traits; LUSC trans rs941408 1.000 rs1736176 chr19:2790394 G/A cg19676328 chr12:49525230 TUBA1B -0.51 -7.94 -0.4 3.02e-14 Total cholesterol levels; LUSC trans rs2587949 0.615 rs1385487 chr3:4228738 G/A cg15139668 chr4:4577005 NA -0.41 -5.96 -0.31 6.47e-9 Periodontitis (DPAL); LUSC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg03676636 chr4:99064102 C4orf37 0.33 7.31 0.37 2e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg16325326 chr1:53192061 ZYG11B -0.7 -10.86 -0.51 1.01e-23 Monocyte count; LUSC cis rs4969178 0.930 rs12601079 chr17:76400329 G/A cg20026190 chr17:76395443 PGS1 0.46 8.2 0.41 5.28e-15 HDL cholesterol levels; LUSC cis rs1832871 0.711 rs7747669 chr6:158664345 A/G cg07165851 chr6:158734300 TULP4 0.5 7.61 0.38 2.81e-13 Height; LUSC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.24 0.59 1.94e-32 Hip circumference adjusted for BMI; LUSC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg06212747 chr3:49208901 KLHDC8B 0.44 5.94 0.31 7.24e-9 Parkinson's disease; LUSC trans rs6502050 0.835 rs6502065 chr17:80095642 T/C cg07393940 chr7:158741817 NA 0.37 6.78 0.35 5.58e-11 Life satisfaction; LUSC trans rs1728785 1.000 rs11075680 chr16:68565700 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg24675658 chr1:53192096 ZYG11B 0.58 9.11 0.45 7.72e-18 Monocyte count; LUSC cis rs7536201 1.000 rs10794667 chr1:25304552 C/T cg23273869 chr1:25296894 NA -0.28 -6.23 -0.32 1.43e-9 Psoriasis vulgaris; LUSC trans rs4468007 0.553 rs4307413 chr9:124576430 A/G cg21642649 chr21:34144118 C21orf66;C21orf49 0.41 5.97 0.31 5.9e-9 Educational attainment; LUSC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg11812906 chr14:75593930 NEK9 -0.63 -10.34 -0.49 6.12e-22 Height; LUSC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.53e-8 Menopause (age at onset); LUSC cis rs4601821 0.823 rs4938013 chr11:113264470 A/C cg14159747 chr11:113255604 NA 0.26 6.17 0.32 2e-9 Alcoholic chronic pancreatitis; LUSC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.47e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg18512352 chr11:47633146 NA -0.46 -9.23 -0.45 3.25e-18 Subjective well-being; LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.16 -0.36 5.11e-12 Menopause (age at onset); LUSC cis rs568617 1.000 rs687672 chr11:65649984 T/C cg19792802 chr11:65647270 CTSW -0.41 -6.31 -0.33 8.84e-10 Crohn's disease; LUSC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs890448 0.796 rs2114365 chr4:102345646 G/A cg05120309 chr14:100485494 NA -0.37 -6.1 -0.32 2.97e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs3755132 0.929 rs4668948 chr2:15771586 A/C cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC trans rs61931739 0.517 rs2636073 chr12:34063049 C/T cg26384229 chr12:38710491 ALG10B 0.7 11.03 0.52 2.5e-24 Morning vs. evening chronotype; LUSC cis rs6762 0.719 rs4895 chr11:840477 A/G cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.7 -0.34 8.78e-11 Mean platelet volume; LUSC cis rs561341 0.609 rs2051810 chr17:30195841 C/T cg00745463 chr17:30367425 LRRC37B 0.63 7.52 0.38 5e-13 Hip circumference adjusted for BMI; LUSC cis rs1577917 1.000 rs955196 chr6:86729951 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.48 6.95 0.36 1.91e-11 Response to antipsychotic treatment; LUSC cis rs55871839 0.708 rs12114218 chr8:59817454 T/C cg07426533 chr8:59803705 TOX -0.36 -5.76 -0.3 1.91e-8 Pneumonia; LUSC cis rs9399401 0.845 rs155259 chr6:142846565 G/A cg03128060 chr6:142623767 GPR126 0.3 5.7 0.3 2.7e-8 Chronic obstructive pulmonary disease; LUSC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg17328964 chr8:145687451 CYHR1 -0.68 -11.75 -0.54 6.65e-27 Age at first birth; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg25253773 chr2:74942436 NA 0.39 6.13 0.32 2.53e-9 Metabolite levels (Pyroglutamine); LUSC cis rs10416265 0.516 rs1270252 chr19:33623604 G/A cg17764715 chr19:33622953 WDR88 -0.58 -6.4 -0.33 5.23e-10 Bone properties (heel); LUSC cis rs6940638 0.688 rs7744759 chr6:27119826 G/A cg12292205 chr6:26970375 C6orf41 -0.39 -5.73 -0.3 2.26e-8 Intelligence (multi-trait analysis); LUSC cis rs8102476 0.743 rs8100395 chr19:38747117 A/G cg14131526 chr19:38747285 PPP1R14A -0.34 -5.98 -0.31 5.75e-9 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2439831 0.867 rs2447211 chr15:43936351 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg06022373 chr22:39101656 GTPBP1 0.82 13.39 0.59 5.21e-33 Menopause (age at onset); LUSC cis rs9527 0.614 rs2153774 chr10:104881035 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs4964805 0.559 rs1469999 chr12:104208111 A/G cg02344784 chr12:104178138 NT5DC3 -0.44 -6.52 -0.34 2.66e-10 Attention deficit hyperactivity disorder; LUSC cis rs9790314 0.586 rs35713426 chr3:161131271 A/G cg03342759 chr3:160939853 NMD3 -0.41 -6.3 -0.33 9.22e-10 Morning vs. evening chronotype; LUSC cis rs11645898 0.748 rs72791112 chr16:72204069 T/A cg14768367 chr16:72042858 DHODH -0.63 -6.92 -0.35 2.31e-11 Blood protein levels; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg00106254 chr7:1943704 MAD1L1 -0.4 -5.91 -0.31 8.29e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.6 0.38 3.12e-13 Electroencephalogram traits; LUSC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg17971929 chr21:40555470 PSMG1 0.8 14.1 0.61 9.16e-36 Cognitive function; LUSC cis rs3960554 0.610 rs11971800 chr7:75731608 C/T cg17325771 chr7:75508891 RHBDD2 -0.41 -6.06 -0.31 3.73e-9 Eotaxin levels; LUSC cis rs2274459 0.841 rs12205398 chr6:33701543 C/T cg06253072 chr6:33679850 C6orf125 0.5 5.92 0.31 7.8e-9 Obesity (extreme); LUSC cis rs713587 0.626 rs62140636 chr2:25233811 T/C cg01884057 chr2:25150051 NA -0.38 -8.49 -0.42 7.11e-16 Body mass index in non-asthmatics; LUSC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg26769984 chr7:1090371 C7orf50 0.7 9.84 0.47 3.09e-20 Bronchopulmonary dysplasia; LUSC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg06873352 chr17:61820015 STRADA 0.72 12.97 0.58 1.89e-31 Prudent dietary pattern; LUSC cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Bladder cancer; LUSC cis rs6500395 1.000 rs4517800 chr16:48677404 T/A cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.86e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2708377 0.929 rs61931269 chr12:11296418 C/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg05623727 chr3:50126028 RBM5 0.31 5.7 0.3 2.61e-8 Intelligence (multi-trait analysis); LUSC cis rs710216 0.912 rs11537640 chr1:43424519 T/G cg03128534 chr1:43423976 SLC2A1 0.45 5.79 0.3 1.67e-8 Red cell distribution width; LUSC trans rs8030485 0.571 rs1402760 chr15:79439159 G/A cg16586880 chr8:140854244 TRAPPC9 -0.39 -6.36 -0.33 6.68e-10 Left ventricle wall thickness; LUSC cis rs354225 0.544 rs10205410 chr2:54799599 G/T cg26097391 chr2:54893211 SPTBN1 0.45 6.49 0.33 3.02e-10 Schizophrenia; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg03776034 chr3:154042375 DHX36 0.32 6.02 0.31 4.69e-9 Metabolite levels (Pyroglutamine); LUSC cis rs2439831 1.000 rs2264239 chr15:43765533 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.28 -0.45 2.27e-18 Gut microbiome composition (summer); LUSC cis rs4919694 1.000 rs10509760 chr10:104634107 A/G cg23093090 chr10:104574429 C10orf26 -0.46 -5.73 -0.3 2.22e-8 Arsenic metabolism; LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC cis rs1322512 0.917 rs2057399 chr6:152950053 C/T cg27316956 chr6:152958899 SYNE1 -0.36 -6.11 -0.32 2.72e-9 Tonometry; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg11764359 chr7:65958608 NA 0.4 5.67 0.3 3.03e-8 Calcium levels; LUSC cis rs61931739 0.500 rs11053166 chr12:34385898 A/C cg06521331 chr12:34319734 NA 0.39 6.05 0.31 3.84e-9 Morning vs. evening chronotype; LUSC cis rs66887589 0.934 rs41464847 chr4:120532401 A/G cg09307838 chr4:120376055 NA -0.41 -6.32 -0.33 8.26e-10 Diastolic blood pressure; LUSC cis rs11711311 1.000 rs7649590 chr3:113447267 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.82 0.35 4.2e-11 IgG glycosylation; LUSC cis rs8067545 0.750 rs34290687 chr17:19991211 G/A cg13482628 chr17:19912719 NA 0.46 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs2413583 0.591 rs17000979 chr22:39700758 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.64 6.32 0.33 8.23e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs6005807 0.719 rs12165715 chr22:29005595 T/C cg12565055 chr22:29076175 TTC28 0.54 5.79 0.3 1.62e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs12220238 1.000 rs7897778 chr10:75916105 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.57 6.78 0.35 5.33e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1577917 0.682 rs1173419 chr6:86402163 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -7.54 -0.38 4.58e-13 Response to antipsychotic treatment; LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg07217954 chr7:1067459 C7orf50 0.54 5.85 0.3 1.17e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03517284 chr6:25882590 NA -0.53 -8.82 -0.43 6.41e-17 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg06640241 chr16:89574553 SPG7 0.91 16.62 0.67 1.26e-45 Multiple myeloma (IgH translocation); LUSC cis rs6138458 0.701 rs6138474 chr20:25012427 T/A cg26195577 chr20:24973756 C20orf3 0.71 10.8 0.51 1.62e-23 Blood protein levels; LUSC cis rs920590 0.560 rs7823457 chr8:19671334 G/A cg03894339 chr8:19674705 INTS10 -0.46 -6.53 -0.34 2.52e-10 Acute lymphoblastic leukemia (childhood); LUSC trans rs11098499 0.908 rs7695996 chr4:120322033 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs950169 0.922 rs62028133 chr15:84919375 A/C cg17173187 chr15:85201210 NMB 0.36 6.41 0.33 5.06e-10 Schizophrenia; LUSC cis rs992157 0.687 rs10206984 chr2:219066980 C/T cg00012203 chr2:219082015 ARPC2 0.87 16.56 0.67 2.26e-45 Colorectal cancer; LUSC cis rs1144713 0.600 rs2683489 chr12:32251181 A/G cg01321189 chr12:32259338 BICD1 0.41 6.99 0.36 1.51e-11 Obesity-related traits; LUSC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.23 0.32 1.37e-9 Menopause (age at onset); LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.86 0.31 1.11e-8 Menopause (age at onset); LUSC trans rs2235573 0.527 rs139878 chr22:38361559 C/T cg19894588 chr14:64061835 NA 0.54 7.68 0.39 1.75e-13 Glioblastoma;Glioma; LUSC trans rs9329221 0.905 rs4610752 chr8:10248962 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.88 -0.4 4.56e-14 Neuroticism; LUSC trans rs2243480 1.000 rs2533288 chr7:66056711 C/G cg10756647 chr7:56101905 PSPH 0.89 9.05 0.44 1.19e-17 Diabetic kidney disease; LUSC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg27068330 chr11:65405492 SIPA1 -0.44 -5.73 -0.3 2.28e-8 Breast cancer; LUSC cis rs66887589 0.934 rs7681980 chr4:120533223 G/A cg09307838 chr4:120376055 NA -0.48 -7.34 -0.37 1.62e-12 Diastolic blood pressure; LUSC cis rs17818399 0.597 rs12104572 chr2:46862466 C/G cg21493583 chr2:46842958 PIGF;CRIPT 0.31 5.67 0.3 3.11e-8 Height; LUSC cis rs2370759 0.891 rs77706860 chr10:32628537 C/T cg01819863 chr10:32635814 EPC1 1.06 10.88 0.51 8.44e-24 Sexual dysfunction (female); LUSC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.49 7.29 0.37 2.25e-12 Schizophrenia; LUSC cis rs17102423 0.594 rs942626 chr14:65550082 C/T cg11161011 chr14:65562177 MAX -0.72 -11.07 -0.52 1.85e-24 Obesity-related traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07805240 chr7:8008383 GLCCI1 -0.52 -6.43 -0.33 4.5e-10 Bipolar disorder and schizophrenia; LUSC cis rs2984613 1 rs2984613 chr1:156197380 C/T cg24450063 chr1:156163899 SLC25A44 1.09 20.87 0.75 1.69e-62 Intracerebral hemorrhage;White matter hyperintensity burden; LUSC cis rs9910055 0.762 rs2526020 chr17:42216588 G/T cg16434002 chr17:42200994 HDAC5 -0.45 -6.39 -0.33 5.66e-10 Total body bone mineral density; LUSC cis rs7246967 0.673 rs2915932 chr19:22843701 C/T cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.44 0.38 8.39e-13 Melanoma; LUSC cis rs13418410 0.539 rs11695597 chr2:33840024 A/G cg04131969 chr2:33951647 MYADML 0.73 10.88 0.51 8.35e-24 Non-response to antidepressants and depression; LUSC cis rs9467711 0.606 rs9379855 chr6:26364930 C/T cg09904177 chr6:26538194 HMGN4 0.71 6.89 0.35 2.78e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs4901869 0.966 rs4901870 chr14:59334221 A/T cg02291164 chr14:59296302 NA -0.58 -11.28 -0.53 3.17e-25 Panic disorder; LUSC cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs4986172 0.539 rs3744760 chr17:43195981 C/T cg10701640 chr17:43249399 NA -0.29 -5.95 -0.31 6.69e-9 Height; LUSC trans rs17685 0.753 rs1104879 chr7:75685568 C/T cg19862616 chr7:65841803 NCRNA00174 1.11 19.36 0.73 1.65e-56 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs8002861 0.967 rs9533691 chr13:44482208 A/G cg12856521 chr11:46389249 DGKZ 0.41 6.33 0.33 8.12e-10 Leprosy; LUSC cis rs7799006 1.000 rs7787274 chr7:2275993 G/A cg12823233 chr7:2316876 SNX8 -0.35 -5.97 -0.31 6.01e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs6942756 1.000 rs67820265 chr7:128887925 A/G cg02491457 chr7:128862824 NA -0.52 -7.39 -0.38 1.15e-12 White matter hyperintensity burden; LUSC cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.78 0.35 5.37e-11 Rheumatoid arthritis; LUSC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.84 -0.47 3.07e-20 Glomerular filtration rate (creatinine); LUSC cis rs7074356 0.915 rs17680103 chr10:82207618 T/C cg00277334 chr10:82204260 NA 0.66 6.26 0.32 1.19e-9 Borderline personality disorder; LUSC cis rs2274273 0.712 rs7144652 chr14:55537718 G/A cg04306507 chr14:55594613 LGALS3 0.49 10.67 0.5 4.55e-23 Protein biomarker; LUSC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg19230755 chr7:65878503 NA -0.43 -6.0 -0.31 5.04e-9 Aortic root size; LUSC cis rs5769707 0.609 rs2007024 chr22:49988815 C/T cg20744362 chr22:50050164 C22orf34 0.36 6.64 0.34 1.29e-10 Monocyte count;Monocyte percentage of white cells; LUSC trans rs656319 0.625 rs34427895 chr8:9875221 G/C cg21775007 chr8:11205619 TDH -0.47 -6.53 -0.34 2.44e-10 Myopia (pathological); LUSC cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg18404041 chr3:52824283 ITIH1 -0.52 -9.81 -0.47 4.05e-20 Intelligence (multi-trait analysis); LUSC cis rs6714710 0.603 rs34373359 chr2:98442202 G/A cg26665480 chr2:98280029 ACTR1B 0.63 9.43 0.46 7.27e-19 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1153858 1.000 rs1618874 chr15:45622786 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.09 0.4 1.08e-14 Homoarginine levels; LUSC cis rs17270561 0.609 rs9358871 chr6:25726675 G/A cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC trans rs11098499 0.954 rs7687843 chr4:120421211 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.02e-14 Corneal astigmatism; LUSC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.55 7.2 0.37 4.06e-12 Multiple sclerosis; LUSC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg22166914 chr1:53195759 ZYG11B 0.69 12.52 0.57 9.17e-30 Monocyte count; LUSC cis rs10266483 0.774 rs1404678 chr7:63802516 A/G cg24201672 chr7:64023550 ZNF680 0.44 5.8 0.3 1.53e-8 Response to statin therapy; LUSC cis rs12912251 0.947 rs7177621 chr15:38999394 C/G cg01338139 chr15:38987640 C15orf53 -0.45 -6.27 -0.32 1.09e-9 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs9457247 0.765 rs6900701 chr6:167434112 A/G cg07741184 chr6:167504864 NA 0.38 6.95 0.36 1.98e-11 Crohn's disease; LUSC cis rs3736594 0.513 rs62131881 chr2:27764781 G/T cg27432699 chr2:27873401 GPN1 0.67 8.86 0.44 4.69e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs2243480 1.000 rs160648 chr7:65543384 C/A cg10756647 chr7:56101905 PSPH 0.87 8.88 0.44 4.33e-17 Diabetic kidney disease; LUSC cis rs11051970 0.566 rs2651372 chr12:32583199 A/G cg02745156 chr12:32552066 NA 0.36 6.51 0.34 2.71e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs709400 0.663 rs7145113 chr14:103945414 A/G cg12935359 chr14:103987150 CKB -0.54 -8.48 -0.42 7.37e-16 Body mass index; LUSC cis rs9300255 0.679 rs58809476 chr12:123724880 C/T cg00376283 chr12:123451042 ABCB9 -0.65 -7.42 -0.38 9.57e-13 Neutrophil percentage of white cells; LUSC cis rs1865760 0.566 rs9379821 chr6:26054268 A/C cg16482183 chr6:26056742 HIST1H1C 0.55 8.12 0.41 9.06e-15 Height; LUSC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg04539111 chr16:67997858 SLC12A4 -0.47 -6.3 -0.33 9.58e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2197308 0.659 rs11181327 chr12:37903171 C/T cg26384229 chr12:38710491 ALG10B -0.82 -13.77 -0.6 1.83e-34 Morning vs. evening chronotype; LUSC cis rs17253792 0.822 rs74720318 chr14:56099828 G/T cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.29e-10 Putamen volume; LUSC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg08048268 chr3:133502702 NA -0.5 -9.91 -0.48 1.87e-20 Iron status biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14089512 chr10:102106757 SCD -0.47 -6.15 -0.32 2.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs9650657 0.615 rs6601534 chr8:10691993 A/G cg27411982 chr8:10470053 RP1L1 -0.37 -6.01 -0.31 4.73e-9 Neuroticism; LUSC cis rs12541635 0.966 rs2132471 chr8:107000963 G/A cg10147462 chr8:107024639 NA 0.55 9.96 0.48 1.27e-20 Age of smoking initiation; LUSC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg23093090 chr10:104574429 C10orf26 -0.43 -7.62 -0.38 2.72e-13 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg24733560 chr20:60626293 TAF4 0.35 5.81 0.3 1.47e-8 Body mass index; LUSC cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg01579765 chr21:45077557 HSF2BP -0.55 -11.6 -0.54 2.32e-26 Mean corpuscular volume; LUSC cis rs1044826 0.597 rs6803593 chr3:139193987 T/C cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.79e-11 Obesity-related traits; LUSC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg21856205 chr7:94953877 PON1 -0.36 -5.76 -0.3 1.95e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs4853012 0.887 rs6737314 chr2:74339586 A/G cg05776053 chr2:74358815 NA 0.4 6.07 0.32 3.47e-9 Gestational age at birth (maternal effect); LUSC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg22496380 chr5:211416 CCDC127 0.81 9.45 0.46 6.34e-19 Breast cancer; LUSC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg00033643 chr7:134001901 SLC35B4 0.47 7.28 0.37 2.41e-12 Mean platelet volume; LUSC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg19592336 chr6:28129416 ZNF389 -0.49 -6.47 -0.33 3.44e-10 Depression; LUSC trans rs1994135 0.617 rs10844642 chr12:33730368 A/C cg13010199 chr12:38710504 ALG10B 0.51 7.06 0.36 9.47e-12 Resting heart rate; LUSC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg26441486 chr22:50317300 CRELD2 0.48 7.1 0.36 7.5e-12 Schizophrenia; LUSC trans rs7824557 0.527 rs2572376 chr8:11237756 C/A cg15556689 chr8:8085844 FLJ10661 -0.46 -6.96 -0.36 1.77e-11 Retinal vascular caliber; LUSC cis rs12791968 1.000 rs11038237 chr11:45001880 C/T cg11846598 chr11:44996168 LOC221122 -0.7 -11.2 -0.52 6.4e-25 Inhibitory control; LUSC trans rs4811340 0.600 rs2869657 chr20:51190821 A/G cg15736553 chr3:11610338 VGLL4 -0.33 -5.99 -0.31 5.4e-9 Thyroid peroxidase antibody positivity; LUSC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg20848291 chr7:100343083 ZAN -0.68 -9.32 -0.45 1.68e-18 Other erythrocyte phenotypes; LUSC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg17264618 chr3:40429014 ENTPD3 -0.36 -7.32 -0.37 1.9e-12 Renal cell carcinoma; LUSC cis rs1904096 0.506 rs10028613 chr4:95223698 T/C cg11021082 chr4:95130006 SMARCAD1 -0.39 -6.99 -0.36 1.48e-11 Type 2 diabetes; LUSC trans rs13424581 1.000 rs11903344 chr2:225733342 G/T cg25639566 chr4:40539823 RBM47 -0.68 -6.03 -0.31 4.4e-9 Platelet distribution width; LUSC cis rs8017423 0.967 rs1005788 chr14:90692747 C/T cg04374321 chr14:90722782 PSMC1 0.72 11.47 0.53 6.92e-26 Mortality in heart failure; LUSC cis rs4319547 0.656 rs7294559 chr12:122837564 C/A cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.27 -0.41 3.18e-15 Body mass index; LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg25036284 chr2:26402008 FAM59B -0.73 -10.66 -0.5 4.85e-23 Gut microbiome composition (summer); LUSC cis rs1577917 0.610 rs11752795 chr6:86287129 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 5.8 0.3 1.5e-8 Response to antipsychotic treatment; LUSC cis rs2658782 0.547 rs3020065 chr11:93059899 A/G cg15737290 chr11:93063684 CCDC67 0.87 13.35 0.59 7.36e-33 Pulmonary function decline; LUSC cis rs950881 0.808 rs72823677 chr2:102997051 C/T cg20060108 chr2:102954350 IL1RL1 0.47 5.71 0.3 2.53e-8 Allergy; LUSC cis rs12908161 1.000 rs35808647 chr15:85377441 G/A cg17173187 chr15:85201210 NMB 0.44 8.03 0.4 1.68e-14 Schizophrenia; LUSC cis rs231513 0.954 rs231514 chr17:41964516 C/T cg26893861 chr17:41843967 DUSP3 -0.55 -6.18 -0.32 1.82e-9 Cognitive function; LUSC cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg24642439 chr20:33292090 TP53INP2 0.49 7.38 0.37 1.23e-12 Height; LUSC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg17279839 chr7:150038598 RARRES2 0.44 6.96 0.36 1.78e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2760061 0.583 rs708124 chr1:228220771 A/T cg18477163 chr1:228402036 OBSCN 0.52 8.97 0.44 2.17e-17 Diastolic blood pressure; LUSC cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg01416388 chr22:39784598 NA 0.44 7.3 0.37 2.08e-12 Intelligence (multi-trait analysis); LUSC cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg27129171 chr3:47204927 SETD2 -0.5 -7.38 -0.37 1.23e-12 Birth weight; LUSC cis rs193541 0.632 rs152038 chr5:122195846 G/A cg19077854 chr5:122220652 SNX24 0.37 7.69 0.39 1.63e-13 Glucose homeostasis traits; LUSC trans rs10946292 0.706 rs11754516 chr6:170434459 T/C cg17832364 chr10:94847294 NA 0.38 6.26 0.32 1.17e-9 Obesity-related traits; LUSC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg22875332 chr1:76189707 ACADM 0.77 10.36 0.49 5.22e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9790314 1.000 rs975323 chr3:161021322 A/G cg04691961 chr3:161091175 C3orf57 -0.35 -5.99 -0.31 5.34e-9 Morning vs. evening chronotype; LUSC cis rs9311676 0.656 rs11917529 chr3:58382158 C/T cg13750441 chr3:58318267 PXK 0.34 6.66 0.34 1.15e-10 Systemic lupus erythematosus; LUSC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg14584255 chr6:163149320 PACRG;PARK2 -0.39 -7.63 -0.39 2.46e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg25174290 chr11:3078921 CARS 0.62 9.89 0.48 2.14e-20 Longevity; LUSC cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg01657329 chr11:68192670 LRP5 -0.44 -6.54 -0.34 2.35e-10 Total body bone mineral density; LUSC trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg06636001 chr8:8085503 FLJ10661 -0.6 -9.48 -0.46 4.97e-19 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7091068 0.566 rs7082701 chr10:95501042 G/T cg20715218 chr10:95462985 C10orf4 0.61 6.54 0.34 2.31e-10 Urinary tract infection frequency; LUSC trans rs9650657 0.513 rs4841459 chr8:10782442 A/C cg15556689 chr8:8085844 FLJ10661 -0.54 -7.86 -0.4 5.45e-14 Neuroticism; LUSC cis rs7188861 0.681 rs9932855 chr16:11406544 G/C cg00044050 chr16:11439710 C16orf75 0.55 5.65 0.3 3.35e-8 HDL cholesterol; LUSC cis rs73206853 0.764 rs7960988 chr12:110749918 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7106204 0.514 rs2099889 chr11:24255971 A/G ch.11.24196551F chr11:24239977 NA 0.93 10.34 0.49 6.32e-22 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7599312 0.532 rs1531788 chr2:213394320 C/T cg16329650 chr2:213403929 ERBB4 0.47 7.09 0.36 8.24e-12 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17270561 0.636 rs9358880 chr6:25743161 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 9.07 0.44 1.01e-17 Iron status biomarkers; LUSC cis rs6598955 0.724 rs884533 chr1:26585657 G/T cg04990556 chr1:26633338 UBXN11 -0.8 -14.87 -0.63 9.73e-39 Obesity-related traits; LUSC cis rs9309473 1.000 rs11899740 chr2:73631212 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.91 -0.35 2.44e-11 Metabolite levels; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 6.45 0.33 3.87e-10 Electroencephalogram traits; LUSC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg25019033 chr10:957182 NA -0.49 -6.37 -0.33 6.38e-10 Eosinophil percentage of granulocytes; LUSC cis rs6681460 0.932 rs492109 chr1:67187133 C/A cg02459107 chr1:67143332 SGIP1 -0.46 -8.53 -0.42 5.01e-16 Presence of antiphospholipid antibodies; LUSC cis rs1728785 0.818 rs1728769 chr16:68564186 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs713477 0.967 rs4243600 chr14:55910679 A/G cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg08859206 chr1:53392774 SCP2 -0.55 -9.55 -0.46 2.86e-19 Monocyte count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17864206 chr1:43855683 C1orf84;MED8 -0.49 -5.98 -0.31 5.63e-9 Bipolar disorder and schizophrenia; LUSC cis rs67366981 1.000 rs425310 chr14:77711497 C/T cg22824376 chr14:77648248 TMEM63C 0.65 6.42 0.33 4.57e-10 Obsessive-compulsive symptoms; LUSC cis rs9902453 0.933 rs7224199 chr17:28523726 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 8.21 0.41 4.76e-15 Coffee consumption (cups per day); LUSC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg13647721 chr17:30228624 UTP6 0.63 6.22 0.32 1.49e-9 Hip circumference adjusted for BMI; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg00730023 chr19:17420725 DDA1 0.75 6.26 0.32 1.15e-9 Cognitive performance; LUSC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg07701084 chr6:150067640 NUP43 0.54 8.12 0.41 9.34e-15 Lung cancer; LUSC cis rs10887741 0.646 rs2077773 chr10:89435501 G/A cg13926569 chr10:89418898 PAPSS2 0.32 6.86 0.35 3.27e-11 Exercise (leisure time); LUSC cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg00012203 chr2:219082015 ARPC2 0.89 17.01 0.68 3.67e-47 Colorectal cancer; LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC cis rs477692 1.000 rs485576 chr10:131425496 G/C cg26102564 chr10:131424627 MGMT 0.42 6.56 0.34 2.1e-10 Response to temozolomide; LUSC cis rs2857891 0.659 rs2638110 chr11:6993922 C/T cg04053776 chr11:6947353 ZNF215 0.43 6.21 0.32 1.57e-9 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18082322 chr5:148725041 GRPEL2 0.76 6.17 0.32 1.92e-9 Cognitive performance; LUSC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg24531977 chr5:56204891 C5orf35 -1.05 -15.46 -0.65 4.78e-41 Initial pursuit acceleration; LUSC cis rs367943 1.000 rs348960 chr5:112820651 C/A cg12552261 chr5:112820674 MCC 0.44 7.11 0.36 7.19e-12 Type 2 diabetes; LUSC cis rs1957429 0.808 rs7149922 chr14:65334541 C/T cg23373153 chr14:65346875 NA 0.97 11.0 0.52 3.19e-24 Pediatric areal bone mineral density (radius); LUSC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.38 7.74 0.39 1.23e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs75804782 0.521 rs56121087 chr2:239435766 A/G cg18131467 chr2:239335373 ASB1 -0.67 -6.01 -0.31 4.73e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg23711669 chr6:146136114 FBXO30 0.91 17.7 0.7 6.39e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.776 rs4316025 chr6:146238032 C/T cg13319975 chr6:146136371 FBXO30 0.47 7.24 0.37 3.19e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7223966 0.921 rs6504186 chr17:61863932 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.96 0.36 1.86e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg15316289 chr22:50310904 ALG12;CRELD2 0.4 5.78 0.3 1.75e-8 Schizophrenia; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg13047869 chr3:10149882 C3orf24 0.66 8.9 0.44 3.62e-17 Alzheimer's disease; LUSC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg25036284 chr2:26402008 FAM59B -0.77 -11.38 -0.53 1.46e-25 Gut microbiome composition (summer); LUSC cis rs12594515 0.967 rs8039088 chr15:45990178 T/C cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs7215564 0.908 rs4889879 chr17:78662573 A/T cg09596252 chr17:78655493 RPTOR -0.57 -6.57 -0.34 1.88e-10 Myopia (pathological); LUSC trans rs1499614 1.000 rs2707828 chr7:66171377 G/A cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs10927875 0.632 rs4661667 chr1:16162731 C/T cg22431228 chr1:16359049 CLCNKA 0.33 6.19 0.32 1.74e-9 Dilated cardiomyopathy; LUSC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs950027 0.584 rs1145086 chr15:45654327 A/G cg21132104 chr15:45694354 SPATA5L1 0.42 6.13 0.32 2.45e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9463078 0.764 rs2396370 chr6:44946472 A/G cg25276700 chr6:44698697 NA -0.29 -5.86 -0.31 1.11e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs793571 0.502 rs421829 chr15:59079902 G/C cg05156742 chr15:59063176 FAM63B 0.55 8.79 0.43 8e-17 Schizophrenia; LUSC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg14004847 chr7:1930337 MAD1L1 0.56 8.66 0.43 2.04e-16 Schizophrenia; LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg22467129 chr15:76604101 ETFA -0.51 -8.26 -0.41 3.38e-15 Blood metabolite levels; LUSC trans rs208520 0.690 rs207740 chr6:66764132 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.74 0.68 4.02e-46 Exhaled nitric oxide output; LUSC trans rs8072100 0.817 rs7213086 chr17:45752310 C/G cg03886242 chr7:26192032 NFE2L3 -0.39 -6.25 -0.32 1.25e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs453301 0.686 rs28482034 chr8:8869664 G/A cg15556689 chr8:8085844 FLJ10661 -0.62 -9.57 -0.46 2.49e-19 Joint mobility (Beighton score); LUSC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg03609598 chr5:56110824 MAP3K1 -0.42 -6.11 -0.32 2.71e-9 Initial pursuit acceleration; LUSC cis rs79149102 0.579 rs7166105 chr15:75343942 A/G cg17294928 chr15:75287854 SCAMP5 0.65 6.17 0.32 1.96e-9 Lung cancer; LUSC cis rs7520050 0.807 rs12025621 chr1:46228391 G/A cg06784218 chr1:46089804 CCDC17 -0.31 -6.07 -0.32 3.47e-9 Red blood cell count;Reticulocyte count; LUSC cis rs559928 0.606 rs12417635 chr11:63912728 C/T cg24687543 chr11:63912206 MACROD1 0.47 5.96 0.31 6.34e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg15445000 chr17:37608096 MED1 -0.39 -6.94 -0.35 2.07e-11 Glomerular filtration rate (creatinine); LUSC cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg12863693 chr15:85201151 NMB 0.35 6.25 0.32 1.25e-9 Schizophrenia; LUSC cis rs4947962 0.585 rs56659219 chr7:55155849 G/T cg23757825 chr7:55092271 EGFR -0.46 -5.67 -0.3 3.08e-8 Subjective response to lithium treatment; LUSC cis rs394563 0.601 rs382720 chr6:149795261 C/T cg11245181 chr6:149772854 ZC3H12D 0.34 6.99 0.36 1.5e-11 Dupuytren's disease; LUSC cis rs9473147 0.516 rs9381575 chr6:47528764 C/G cg20196966 chr6:47445060 CD2AP 0.41 5.73 0.3 2.24e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs1568889 1.000 rs61889046 chr11:28297024 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 9.46 0.46 5.52e-19 Bipolar disorder; LUSC cis rs17685 0.712 rs56965035 chr7:75795670 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs11039100 0.850 rs11039115 chr11:5831379 T/C cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs4720118 1.000 rs758780 chr7:33478460 A/G cg23247845 chr10:3679085 NA -0.34 -6.0 -0.31 5.07e-9 Leprosy; LUSC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg20476274 chr7:133979776 SLC35B4 0.83 14.82 0.63 1.55e-38 Mean platelet volume; LUSC cis rs12681288 0.862 rs2701898 chr8:1020812 C/T cg04851639 chr8:1020857 NA -0.39 -8.19 -0.41 5.55e-15 Schizophrenia; LUSC cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg26373071 chr5:1325741 CLPTM1L 0.42 7.91 0.4 3.84e-14 Lung cancer; LUSC trans rs61931739 0.534 rs11053014 chr12:34103519 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg06634786 chr22:41940651 POLR3H -0.55 -6.46 -0.33 3.75e-10 Vitiligo; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23961059 chr19:57874869 ZNF547;TRAPPC2P1 0.47 6.45 0.33 3.85e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg17968037 chr7:100024898 ZCWPW1 -0.42 -5.92 -0.31 8.14e-9 Platelet count; LUSC trans rs459571 0.920 rs2520094 chr9:136919985 A/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -12.18 -0.55 1.8e-28 Platelet distribution width; LUSC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg01416388 chr22:39784598 NA -0.44 -6.84 -0.35 3.85e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs72781680 0.898 rs55761273 chr2:23957849 A/G cg20701182 chr2:24300061 SF3B14 0.55 5.85 0.3 1.2e-8 Lymphocyte counts; LUSC cis rs11587682 0.714 rs74127616 chr1:150459324 G/A cg11822372 chr1:151115635 SEMA6C -0.42 -5.71 -0.3 2.53e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs950776 0.616 rs56276142 chr15:78889795 T/C cg22563815 chr15:78856949 CHRNA5 0.25 6.24 0.32 1.36e-9 Sudden cardiac arrest; LUSC cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg11266682 chr4:10021025 SLC2A9 0.58 10.7 0.51 3.69e-23 Bone mineral density; LUSC cis rs6121246 0.567 rs6120879 chr20:30202961 T/C cg18721089 chr20:30220636 NA -0.37 -5.75 -0.3 2.05e-8 Mean corpuscular hemoglobin; LUSC cis rs9888739 1.000 rs11860650 chr16:31326706 C/T cg15817542 chr16:31343056 ITGAM -0.51 -6.12 -0.32 2.58e-9 Systemic lupus erythematosus; LUSC cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg06636001 chr8:8085503 FLJ10661 -0.64 -9.61 -0.47 1.87e-19 Mood instability; LUSC cis rs950027 0.620 rs1153860 chr15:45636584 A/G cg26924012 chr15:45694286 SPATA5L1 -0.77 -12.46 -0.56 1.53e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg04455712 chr21:45112962 RRP1B 0.44 8.35 0.42 1.9e-15 Mean corpuscular volume; LUSC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg24838063 chr12:130822603 PIWIL1 0.68 10.69 0.51 3.78e-23 Menopause (age at onset); LUSC cis rs2795502 1.000 rs2795502 chr10:43340662 G/A cg27426351 chr10:43362370 NA -0.43 -5.92 -0.31 8.17e-9 Blood protein levels; LUSC cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.12e-18 Menopause (age at onset); LUSC cis rs1371867 0.846 rs1788196 chr8:101290088 C/T cg06002616 chr8:101225028 SPAG1 -0.41 -6.93 -0.35 2.21e-11 Atrioventricular conduction; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg14004847 chr7:1930337 MAD1L1 -0.51 -7.54 -0.38 4.49e-13 Bipolar disorder and schizophrenia; LUSC cis rs12893668 0.703 rs4906336 chr14:104033265 C/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -6.4 -0.33 5.27e-10 Reticulocyte count; LUSC cis rs7202877 0.561 rs9933956 chr16:75362813 T/C cg03315344 chr16:75512273 CHST6 0.42 6.14 0.32 2.39e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg04362960 chr10:104952993 NT5C2 0.57 8.97 0.44 2.18e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11098499 0.863 rs3775849 chr4:120450908 G/C cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs9527 0.590 rs10883834 chr10:104881402 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC trans rs853679 1.000 rs6905391 chr6:28262686 G/A cg01620082 chr3:125678407 NA -0.54 -6.56 -0.34 2.07e-10 Depression; LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.65 0.34 1.17e-10 Menopause (age at onset); LUSC cis rs977987 0.843 rs12928036 chr16:75483132 G/A cg04384234 chr16:75411784 CFDP1 -0.44 -7.34 -0.37 1.6e-12 Dupuytren's disease; LUSC cis rs6840360 0.571 rs12650655 chr4:152556075 G/A cg22705602 chr4:152727874 NA -0.31 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg18357645 chr12:58087776 OS9 -0.53 -7.65 -0.39 2.1e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 -0.43 -6.83 -0.35 4.1e-11 Vitiligo; LUSC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg23422044 chr7:1970798 MAD1L1 -0.53 -5.72 -0.3 2.36e-8 Bipolar disorder; LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg20887711 chr4:1340912 KIAA1530 0.71 11.17 0.52 7.93e-25 Longevity; LUSC cis rs7719624 0.792 rs4976459 chr5:135362573 C/G cg12897067 chr5:135418308 NA -0.41 -5.85 -0.3 1.18e-8 Response to cytidine analogues (gemcitabine); LUSC cis rs7246967 0.673 rs62120125 chr19:22955099 T/A cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg20887711 chr4:1340912 KIAA1530 0.7 10.84 0.51 1.2e-23 Longevity; LUSC cis rs1728785 1.000 rs1728773 chr16:68563644 A/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg25039879 chr17:56429692 SUPT4H1 0.71 9.61 0.47 1.77e-19 Cognitive test performance; LUSC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.96 -0.4 2.7e-14 Aortic root size; LUSC cis rs3760982 0.845 rs62116962 chr19:44287234 A/G cg11993925 chr19:44307056 LYPD5 -0.28 -6.25 -0.32 1.25e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs11992162 0.573 rs13275808 chr8:11782815 T/C cg06636001 chr8:8085503 FLJ10661 -0.44 -6.37 -0.33 6.25e-10 Monocyte count; LUSC cis rs7911264 0.739 rs6583827 chr10:94358023 A/T cg25093409 chr10:94429542 NA 0.36 6.21 0.32 1.59e-9 Inflammatory bowel disease; LUSC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 11.75 0.54 6.64e-27 Personality dimensions; LUSC cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs427394 0.659 rs274695 chr5:6732252 G/C cg10857441 chr5:6722123 POLS -0.45 -8.31 -0.41 2.44e-15 Menopause (age at onset); LUSC cis rs362296 0.661 rs3095077 chr4:3265710 A/G cg14583973 chr4:3374767 RGS12 0.29 5.66 0.3 3.34e-8 Parental longevity (mother's age at death); LUSC cis rs3806843 0.576 rs246020 chr5:140334771 G/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21701354 chr7:129592850 UBE2H -0.58 -6.88 -0.35 2.96e-11 Bipolar disorder and schizophrenia; LUSC cis rs10089 1.000 rs4836366 chr5:127482494 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.88 12.44 0.56 1.93e-29 Ileal carcinoids; LUSC cis rs10761482 0.906 rs7093702 chr10:62093709 A/C cg18175470 chr10:62150864 ANK3 -0.49 -6.95 -0.36 1.98e-11 Schizophrenia; LUSC cis rs10979 0.931 rs12191837 chr6:143898200 T/G cg25407410 chr6:143891975 LOC285740 -0.75 -12.1 -0.55 3.36e-28 Hypospadias; LUSC cis rs1832871 0.672 rs111782080 chr6:158765385 G/A cg07165851 chr6:158734300 TULP4 0.46 6.95 0.36 1.98e-11 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27109827 chr16:28936530 RABEP2 -0.41 -6.31 -0.33 8.82e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg20406979 chr6:167373233 NA 0.26 6.15 0.32 2.25e-9 Crohn's disease; LUSC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg02269571 chr22:50332266 NA -0.6 -9.04 -0.44 1.35e-17 Schizophrenia; LUSC cis rs9467773 1.000 rs2224380 chr6:26553943 G/A cg05738196 chr6:26577821 NA 0.83 16.11 0.66 1.29e-43 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg06634786 chr22:41940651 POLR3H 0.48 5.84 0.3 1.21e-8 Vitiligo; LUSC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg16145915 chr7:1198662 ZFAND2A -0.4 -5.68 -0.3 2.88e-8 Bronchopulmonary dysplasia; LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.79 -0.57 9.23e-31 Platelet count; LUSC cis rs10504073 0.647 rs55920380 chr8:50026353 G/A cg00325661 chr8:49890786 NA 0.61 9.52 0.46 3.51e-19 Blood metabolite ratios; LUSC cis rs2439831 0.681 rs1549523 chr15:43624189 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.44 0.65 5.93e-41 Lung cancer in ever smokers; LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg00166722 chr3:10149974 C3orf24 0.61 8.64 0.43 2.44e-16 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15473325 chr12:133137087 FBRSL1 0.45 6.11 0.32 2.78e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2404602 0.735 rs11635463 chr15:76762986 C/T cg23625390 chr15:77176239 SCAPER -0.62 -9.58 -0.46 2.23e-19 Blood metabolite levels; LUSC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs11989744 0.500 rs7826966 chr8:23569106 G/T cg03492747 chr16:86543808 FOXF1 -0.64 -11.12 -0.52 1.23e-24 Waist-hip ratio; LUSC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg20607798 chr8:58055168 NA 0.53 5.85 0.3 1.2e-8 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7395662 0.611 rs7478698 chr11:48549139 T/C cg15704280 chr7:45808275 SEPT13 -0.46 -6.34 -0.33 7.64e-10 HDL cholesterol; LUSC cis rs611744 0.870 rs685358 chr8:109161413 T/C cg18478394 chr8:109455254 TTC35 0.41 6.19 0.32 1.75e-9 Dupuytren's disease; LUSC cis rs67311347 0.577 rs2887951 chr3:40282104 C/G cg13683864 chr3:40499215 RPL14 -0.82 -13.29 -0.59 1.18e-32 Renal cell carcinoma; LUSC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg11871910 chr12:69753446 YEATS4 0.83 14.55 0.62 1.67e-37 Blood protein levels; LUSC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg06481639 chr22:41940642 POLR3H 0.49 5.81 0.3 1.48e-8 Vitiligo; LUSC cis rs7954584 0.523 rs11043280 chr12:122426643 T/C cg22618164 chr12:122356400 WDR66 0.6 8.87 0.44 4.53e-17 Mean corpuscular volume; LUSC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg14403583 chr14:105418241 AHNAK2 -0.57 -9.62 -0.47 1.66e-19 Rheumatoid arthritis; LUSC cis rs12210905 0.688 rs12189640 chr6:27474657 T/C cg08851530 chr6:28072375 NA 0.95 6.15 0.32 2.21e-9 Hip circumference adjusted for BMI; LUSC cis rs7829975 0.567 rs6601273 chr8:8796519 T/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.59 -0.43 3.36e-16 Mood instability; LUSC cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg14343924 chr8:8086146 FLJ10661 -0.42 -5.81 -0.3 1.42e-8 Myopia (pathological); LUSC cis rs76419734 0.510 rs7659526 chr4:106621643 T/C cg24545054 chr4:106630052 GSTCD;INTS12 0.64 7.85 0.39 5.57e-14 Post bronchodilator FEV1; LUSC cis rs11690462 0.528 rs11691698 chr2:26642190 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.51 6.57 0.34 1.96e-10 Coronary artery disease; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg27588902 chr6:42928151 GNMT -0.29 -6.59 -0.34 1.71e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg00484396 chr16:3507460 NAT15 0.49 7.25 0.37 2.84e-12 Body mass index (adult); LUSC cis rs9473147 0.516 rs9463342 chr6:47585106 A/T cg12968598 chr6:47444699 CD2AP 0.53 8.1 0.41 1.06e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg18230493 chr5:56204884 C5orf35 -0.94 -14.17 -0.61 5.14e-36 Initial pursuit acceleration; LUSC cis rs11677370 0.561 rs4849990 chr2:3819558 A/G cg17052675 chr2:3827356 NA -0.64 -10.03 -0.48 7.26e-21 Type 2 diabetes; LUSC cis rs6076065 0.692 rs2424549 chr20:23394563 C/A cg11657817 chr20:23433608 CST11 0.44 8.19 0.41 5.54e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs67397200 0.632 rs11666308 chr19:17437744 T/C cg04248312 chr19:17393744 ANKLE1 -0.42 -6.16 -0.32 2.13e-9 Breast cancer;Breast Cancer in BRCA1 mutation carriers;Breast cancer (estrogen-receptor negative); LUSC trans rs9291683 0.554 rs7668175 chr4:10125782 T/C cg26043149 chr18:55253948 FECH -0.53 -7.64 -0.39 2.26e-13 Bone mineral density; LUSC cis rs870825 0.616 rs6843185 chr4:185649878 A/C cg04058563 chr4:185651563 MLF1IP 0.83 12.97 0.58 2.03e-31 Blood protein levels; LUSC cis rs4975709 1.000 rs2279588 chr5:1878021 G/A cg20790798 chr5:1857306 NA -0.39 -5.76 -0.3 1.86e-8 Cardiovascular disease risk factors; LUSC cis rs6076065 0.723 rs2424544 chr20:23390314 C/T cg11657817 chr20:23433608 CST11 0.42 8.01 0.4 1.94e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs9326248 1.000 rs7107152 chr11:117056080 C/T cg26566898 chr11:117069891 TAGLN -0.46 -8.21 -0.41 4.76e-15 Blood protein levels; LUSC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg21361702 chr7:150065534 REPIN1 0.47 6.17 0.32 1.94e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 7.45 0.38 7.96e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs859767 0.741 rs13432068 chr2:135382914 G/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.28 -0.32 1.07e-9 Neuroticism; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg14092988 chr3:52407081 DNAH1 0.32 6.28 0.33 1.04e-9 Bipolar disorder; LUSC cis rs7587476 0.822 rs13018304 chr2:215682218 T/G cg04004882 chr2:215674386 BARD1 0.47 6.2 0.32 1.62e-9 Neuroblastoma; LUSC cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.1 0.55 3.3e-28 Motion sickness; LUSC trans rs2243480 1.000 rs1796220 chr7:66062100 C/T cg10756647 chr7:56101905 PSPH 0.88 8.95 0.44 2.46e-17 Diabetic kidney disease; LUSC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg17376030 chr22:41985996 PMM1 -0.48 -6.04 -0.31 4.06e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2732480 0.500 rs2450986 chr12:48661688 G/A cg04545296 chr12:48745243 ZNF641 0.33 6.14 0.32 2.4e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs11098499 0.863 rs12508173 chr4:120318526 T/C cg25214090 chr10:38739885 LOC399744 0.54 7.82 0.39 6.86e-14 Corneal astigmatism; LUSC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg26727032 chr16:67993705 SLC12A4 -0.44 -5.87 -0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs611744 0.647 rs589347 chr8:109253929 T/A cg18478394 chr8:109455254 TTC35 0.41 6.29 0.33 9.7e-10 Dupuytren's disease; LUSC trans rs877282 0.853 rs11253332 chr10:755262 G/C cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg01125463 chr6:42946178 PEX6 -0.36 -6.0 -0.31 5.07e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7937682 1.000 rs10502147 chr11:111569931 G/A cg09085632 chr11:111637200 PPP2R1B 1.08 15.88 0.66 1.05e-42 Primary sclerosing cholangitis; LUSC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.64 14.3 0.62 1.64e-36 Hemoglobin concentration; LUSC cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg15595755 chr5:1867978 NA 0.44 7.73 0.39 1.24e-13 Cardiovascular disease risk factors; LUSC cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg05283184 chr6:79620031 NA -0.57 -12.04 -0.55 5.76e-28 Intelligence (multi-trait analysis); LUSC cis rs4842666 0.915 rs11105353 chr12:90026463 C/A cg00757033 chr12:89920650 WDR51B 0.48 6.39 0.33 5.49e-10 Blood pressure; LUSC trans rs2288327 0.673 rs6723399 chr2:179381715 G/C cg14011486 chr1:26737247 LIN28 0.55 7.43 0.38 9e-13 Atrial fibrillation; LUSC cis rs9888739 1.000 rs36055763 chr16:31299775 C/T cg15817542 chr16:31343056 ITGAM -0.51 -5.99 -0.31 5.3300000000000004e-09 Systemic lupus erythematosus; LUSC cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg25258033 chr6:167368657 RNASET2 0.38 5.86 0.31 1.11e-8 Primary biliary cholangitis; LUSC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg06808227 chr14:105710500 BRF1 -0.64 -9.5 -0.46 4.19e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs921665 0.831 rs11682390 chr2:3187698 G/A cg16434511 chr2:3151078 NA -0.62 -6.62 -0.34 1.43e-10 World class endurance athleticism; LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg14004847 chr7:1930337 MAD1L1 -0.44 -6.41 -0.33 4.94e-10 Bipolar disorder and schizophrenia; LUSC cis rs7909074 0.899 rs2026428 chr10:45389452 T/C cg05187965 chr10:45406764 TMEM72 -0.38 -9.01 -0.44 1.62e-17 Mean corpuscular volume; LUSC trans rs61931739 0.534 rs2636082 chr12:34061848 T/A cg13010199 chr12:38710504 ALG10B 0.54 8.18 0.41 5.97e-15 Morning vs. evening chronotype; LUSC cis rs9309473 0.528 rs79799178 chr2:73791235 A/G cg20560298 chr2:73613845 ALMS1 -0.55 -6.47 -0.33 3.51e-10 Metabolite levels; LUSC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg07828024 chr6:149772892 ZC3H12D 0.34 7.3 0.37 2.13e-12 Dupuytren's disease; LUSC trans rs11148252 0.740 rs9536046 chr13:52955899 T/G cg18335740 chr13:41363409 SLC25A15 0.6 9.05 0.44 1.16e-17 Lewy body disease; LUSC cis rs10876993 0.928 rs1689587 chr12:58075398 A/G cg15848620 chr12:58087721 OS9 -0.57 -8.04 -0.4 1.56e-14 Celiac disease or Rheumatoid arthritis; LUSC trans rs1493935 0.545 rs3134079 chr8:119839850 C/T cg21751525 chr12:120910288 DYNLL1 0.41 6.27 0.32 1.09e-9 Eosinophil percentage of white cells; LUSC cis rs4363385 0.747 rs4323653 chr1:152983359 T/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.67 -0.39 1.9e-13 Inflammatory skin disease; LUSC cis rs4660306 0.614 rs1765711 chr1:45936285 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.42 5.8 0.3 1.55e-8 Homocysteine levels; LUSC cis rs2439831 0.681 rs540031 chr15:43608855 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.92 11.06 0.52 2e-24 Lung cancer in ever smokers; LUSC cis rs11785693 0.862 rs1156861 chr8:4984434 G/C cg26367366 chr8:4980734 NA 0.8 9.47 0.46 5.19e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC trans rs11039798 0.507 rs56994343 chr11:48896970 G/A cg03929089 chr4:120376271 NA 0.69 7.57 0.38 3.76e-13 Axial length; LUSC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.722 rs10006192 chr4:120263022 T/C cg09307838 chr4:120376055 NA 0.64 9.67 0.47 1.19e-19 Corneal astigmatism; LUSC cis rs7809950 1.000 rs2520249 chr7:107146748 A/G cg23024343 chr7:107201750 COG5 -0.54 -8.65 -0.43 2.15e-16 Coronary artery disease; LUSC cis rs3862030 0.810 rs11593710 chr10:104328719 A/C cg05855489 chr10:104503620 C10orf26 0.48 7.35 0.37 1.55e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.74 7.42 0.38 9.87e-13 Initial pursuit acceleration; LUSC cis rs17401966 0.522 rs10492969 chr1:10286358 T/C cg19773385 chr1:10388646 KIF1B -0.36 -6.13 -0.32 2.51e-9 Hepatocellular carcinoma; LUSC cis rs73206853 0.841 rs73206883 chr12:110849549 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 6.97 0.36 1.71e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg17385448 chr1:15911702 AGMAT 0.36 6.18 0.32 1.82e-9 Systolic blood pressure; LUSC cis rs10892173 0.566 rs10892175 chr11:117674355 G/A cg21640587 chr11:117668038 DSCAML1 0.65 9.43 0.46 6.91e-19 Myopia; LUSC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg04518342 chr5:131593106 PDLIM4 -0.43 -7.5 -0.38 5.77e-13 Breast cancer; LUSC cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.17e-9 Blood metabolite levels; LUSC cis rs7527798 0.544 rs11118354 chr1:207856868 A/G cg09232269 chr1:207846808 CR1L -0.31 -6.71 -0.34 8.55e-11 Erythrocyte sedimentation rate; LUSC cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.85 -0.35 3.55e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg24531977 chr5:56204891 C5orf35 -0.87 -11.96 -0.55 1.13e-27 Initial pursuit acceleration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16563178 chr3:50358443 HYAL2 0.44 6.51 0.34 2.74e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1728785 1.000 rs7192341 chr16:68569224 G/C cg02508848 chr16:68573721 ZFP90 -0.42 -5.68 -0.3 2.96e-8 Ulcerative colitis; LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg14004847 chr7:1930337 MAD1L1 -0.51 -7.84 -0.39 6.14e-14 Bipolar disorder and schizophrenia; LUSC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg08499158 chr17:42289980 UBTF -0.51 -8.14 -0.41 7.79e-15 Total body bone mineral density; LUSC trans rs17685 0.925 rs1057868 chr7:75615006 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 12.34 0.56 4.48e-29 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6120849 0.518 rs11696652 chr20:33637060 T/G cg24642439 chr20:33292090 TP53INP2 0.6 6.58 0.34 1.8e-10 Protein C levels; LUSC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg21361702 chr7:150065534 REPIN1 0.45 6.28 0.33 1.03e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg05283184 chr6:79620031 NA -0.57 -12.33 -0.56 4.63e-29 Intelligence (multi-trait analysis); LUSC cis rs5758511 0.573 rs4501042 chr22:42245763 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.4 -7.46 -0.38 7.45e-13 Birth weight; LUSC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs66887589 0.616 rs11098497 chr4:120187068 C/T cg09307838 chr4:120376055 NA 0.5 7.53 0.38 4.84e-13 Diastolic blood pressure; LUSC cis rs2607426 1.000 rs2607423 chr19:41275487 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.63 5.7 0.3 2.68e-8 Blood protein levels; LUSC cis rs67311347 0.955 rs2123999 chr3:40378738 C/T cg13683864 chr3:40499215 RPL14 -0.93 -16.27 -0.66 3.02e-44 Renal cell carcinoma; LUSC cis rs8072100 0.846 rs6503796 chr17:45765249 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.36 -6.12 -0.32 2.56e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg25258033 chr6:167368657 RNASET2 0.44 7.05 0.36 1.04e-11 Crohn's disease; LUSC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 7.33 0.37 1.77e-12 Cerebrospinal P-tau181p levels; LUSC trans rs2235573 0.527 rs139886 chr22:38371328 C/T cg19894588 chr14:64061835 NA 0.5 7.26 0.37 2.78e-12 Glioblastoma;Glioma; LUSC cis rs7267979 0.966 rs4815414 chr20:25361701 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg11812906 chr14:75593930 NEK9 -0.62 -10.45 -0.5 2.6e-22 Height; LUSC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg06618935 chr21:46677482 NA -0.37 -7.52 -0.38 5.25e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10992471 0.528 rs10992347 chr9:95220633 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.35 -6.14 -0.32 2.33e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg18512352 chr11:47633146 NA -0.46 -9.21 -0.45 3.59e-18 Subjective well-being; LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg08859206 chr1:53392774 SCP2 0.51 8.65 0.43 2.13e-16 Monocyte count; LUSC cis rs469568 0.673 rs338876 chr5:178669870 A/G cg08999896 chr5:178685787 ADAMTS2 0.29 5.78 0.3 1.69e-8 Stroke (pediatric); LUSC cis rs7705502 1.000 rs55924019 chr5:173375257 A/G cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.33e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01230929 chr5:133706738 UBE2B -0.42 -5.95 -0.31 6.95e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7223966 1.000 rs112143304 chr17:61822401 T/A cg00945038 chr17:61921165 SMARCD2 0.4 5.76 0.3 1.95e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg24154853 chr7:158122151 PTPRN2 -0.41 -7.93 -0.4 3.38e-14 Calcium levels; LUSC cis rs7572644 0.603 rs7580274 chr2:28266069 C/T cg27432699 chr2:27873401 GPN1 -0.52 -7.07 -0.36 8.88e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.72 0.47 8.03e-20 Personality dimensions; LUSC cis rs41271951 0.512 rs12070256 chr1:151070090 C/T cg11822372 chr1:151115635 SEMA6C -0.76 -6.95 -0.36 1.98e-11 Blood protein levels; LUSC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11890956 chr21:40555474 PSMG1 1.04 21.22 0.76 6.93e-64 Cognitive function; LUSC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -19.14 -0.72 1.16e-55 Height; LUSC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg13393036 chr8:95962371 TP53INP1 -0.35 -6.67 -0.34 1.04e-10 Type 2 diabetes; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg00684032 chr4:1343700 KIAA1530 0.38 6.6 0.34 1.62e-10 Obesity-related traits; LUSC cis rs6733011 0.578 rs1581250 chr2:99500750 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.83 -0.3 1.3e-8 Bipolar disorder; LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg16606324 chr3:10149918 C3orf24 0.58 8.23 0.41 4.27e-15 Alzheimer's disease; LUSC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg18876405 chr7:65276391 NA 0.49 7.68 0.39 1.76e-13 Calcium levels; LUSC cis rs10072221 0.836 rs11740038 chr5:75692003 G/T cg03132911 chr5:75698732 IQGAP2 -0.38 -6.15 -0.32 2.27e-9 Mean platelet volume; LUSC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg08888203 chr3:10149979 C3orf24 0.45 6.79 0.35 5.25e-11 Alzheimer's disease; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg16031515 chr1:205743344 RAB7L1 0.27 5.83 0.3 1.32e-8 Menarche (age at onset); LUSC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.58 0.38 3.46e-13 Bipolar disorder; LUSC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg09365446 chr1:150670422 GOLPH3L 0.44 6.76 0.35 6.23e-11 Melanoma; LUSC cis rs11229555 0.645 rs7947248 chr11:58197750 C/T cg15696309 chr11:58395628 NA -0.67 -8.13 -0.41 8.64e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4730250 0.707 rs257385 chr7:106807448 T/C cg02696742 chr7:106810147 HBP1 -0.66 -9.21 -0.45 3.62e-18 Osteoarthritis; LUSC cis rs11155671 0.530 rs9371542 chr6:150213085 A/T cg09699651 chr6:150184138 LRP11 0.45 7.08 0.36 8.5e-12 Testicular germ cell tumor; LUSC cis rs7089973 0.836 rs1046492 chr10:116624067 C/T cg23260525 chr10:116636907 FAM160B1 0.4 8.11 0.41 9.5e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6500602 0.787 rs7204624 chr16:4459834 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs425277 0.585 rs3107143 chr1:2045372 G/C cg19257562 chr1:2043853 PRKCZ 0.32 6.46 0.33 3.77e-10 Height; LUSC cis rs3740713 1.000 rs35593189 chr11:18468378 C/T cg15463284 chr11:18477534 LDHAL6A -0.52 -6.01 -0.31 4.79e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg10556349 chr10:835070 NA 0.57 6.32 0.33 8.28e-10 Eosinophil percentage of granulocytes; LUSC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg09238746 chr17:78121135 EIF4A3 -0.97 -14.4 -0.62 6.71e-37 Yeast infection; LUSC cis rs7903847 0.642 rs11817875 chr10:99158414 G/A cg08345082 chr10:99160200 RRP12 -0.35 -6.99 -0.36 1.53e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs7568458 0.870 rs6733913 chr2:85757379 T/C cg23752985 chr2:85803571 VAMP8 0.33 7.06 0.36 9.48e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9902453 0.845 rs62068583 chr17:28001482 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.39 0.46 9.81e-19 Coffee consumption (cups per day); LUSC cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg10523860 chr14:103875565 MARK3 -0.36 -5.66 -0.3 3.25e-8 Body mass index; LUSC cis rs708547 0.830 rs1713994 chr4:57868367 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.66 9.09 0.45 9.32e-18 Response to bleomycin (chromatid breaks); LUSC cis rs7709377 0.620 rs12054994 chr5:115477172 A/C cg23108291 chr5:115420582 COMMD10 0.4 5.71 0.3 2.48e-8 Metabolite levels (X-11787); LUSC cis rs7923609 0.841 rs7920036 chr10:65293860 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.46 -0.33 3.74e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs11098499 0.774 rs11098505 chr4:120284627 C/T cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.72 -0.35 7.73e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs3806843 1.000 rs10066278 chr5:140156318 A/C cg26395211 chr5:140044315 WDR55 -0.39 -6.0 -0.31 5.07e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs12291225 0.639 rs61883858 chr11:14294708 C/T cg05501817 chr11:14380813 RRAS2 -0.57 -8.9 -0.44 3.72e-17 Sense of smell; LUSC cis rs7223966 1.000 rs8075273 chr17:61728881 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.92 0.35 2.25e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 13.98 0.61 2.73e-35 Platelet count; LUSC trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg03929089 chr4:120376271 NA 0.83 11.28 0.53 3.15e-25 Height; LUSC cis rs3764563 1.000 rs4646530 chr19:15735238 A/T cg20725493 chr19:15740067 CYP4F8 0.64 6.91 0.35 2.43e-11 Inflammatory biomarkers; LUSC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs3820928 0.874 rs10166456 chr2:227900113 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.8 -0.39 7.86e-14 Pulmonary function; LUSC cis rs262150 0.672 rs2730230 chr7:158788529 A/G cg09640425 chr7:158790006 NA -0.41 -6.08 -0.32 3.31e-9 Facial morphology (factor 20); LUSC cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.67 -0.39 1.89e-13 Joint mobility (Beighton score); LUSC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.03 0.44 1.42e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs950169 0.810 rs62029594 chr15:84955252 T/C cg17173187 chr15:85201210 NMB 0.37 6.4 0.33 5.31e-10 Schizophrenia; LUSC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg05738196 chr6:26577821 NA -0.56 -6.9 -0.35 2.58e-11 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.42 0.53 9.8e-26 Prudent dietary pattern; LUSC cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.03 0.36 1.16e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs62400317 0.859 rs6919873 chr6:45159336 A/G cg20913747 chr6:44695427 NA -0.47 -7.62 -0.38 2.69e-13 Total body bone mineral density; LUSC cis rs1023500 0.573 rs133381 chr22:42470608 C/G cg05082376 chr22:42548792 NA -0.4 -6.04 -0.31 4.1e-9 Schizophrenia; LUSC cis rs11955175 1.000 rs75929994 chr5:40821816 T/C cg17351974 chr5:40835760 RPL37 0.67 5.67 0.3 3.03e-8 Bipolar disorder and schizophrenia; LUSC cis rs4654899 0.931 rs12723255 chr1:21233570 C/T cg01072550 chr1:21505969 NA 0.51 7.67 0.39 1.94e-13 Superior frontal gyrus grey matter volume; LUSC cis rs7940866 0.770 rs10750456 chr11:130819634 A/G cg12179176 chr11:130786555 SNX19 0.62 9.33 0.45 1.5e-18 Schizophrenia; LUSC cis rs1865760 0.865 rs9467641 chr6:25947236 T/C cg17691542 chr6:26056736 HIST1H1C 0.47 7.01 0.36 1.29e-11 Height; LUSC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg25643088 chr3:52874325 TMEM110 0.41 6.3 0.33 9.6e-10 Schizophrenia; LUSC cis rs7202877 0.656 rs4888394 chr16:75413709 T/C cg03315344 chr16:75512273 CHST6 0.44 6.48 0.33 3.35e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs11030122 0.702 rs17279635 chr11:3973083 A/C cg18678763 chr11:4115507 RRM1 0.44 5.81 0.3 1.44e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs9457247 0.934 rs2345571 chr6:167403400 T/G cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg06212747 chr3:49208901 KLHDC8B 0.54 7.13 0.36 6.21e-12 Parkinson's disease; LUSC cis rs1865760 0.566 rs9358902 chr6:26058570 C/G cg16482183 chr6:26056742 HIST1H1C 0.55 8.12 0.41 9.06e-15 Height; LUSC cis rs921968 0.643 rs586374 chr2:219383003 A/C cg02176678 chr2:219576539 TTLL4 0.64 11.72 0.54 8.56e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.966 rs4813557 chr20:25292545 C/T cg08601574 chr20:25228251 PYGB -0.44 -6.69 -0.34 9.36e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10740039 0.883 rs7476720 chr10:62410368 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.89 -0.35 2.79e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10276381 0.892 rs7786444 chr7:28154384 C/T cg23620719 chr7:28220237 JAZF1 0.53 5.69 0.3 2.84e-8 Crohn's disease; LUSC trans rs1493916 1.000 rs11081827 chr18:31390228 C/A cg13755796 chr4:20253514 NA -0.45 -6.98 -0.36 1.55e-11 Life satisfaction; LUSC cis rs4906332 0.966 rs12185021 chr14:103927805 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.78e-12 Coronary artery disease; LUSC trans rs931812 0.757 rs34988706 chr8:101907062 C/T cg20993868 chr7:22813445 NA 0.53 9.66 0.47 1.2e-19 Attention deficit hyperactivity disorder and conduct disorder; LUSC trans rs7605827 0.893 rs4668929 chr2:15719044 C/A cg02506360 chr16:46963989 GPT2 -0.4 -5.94 -0.31 7.04e-9 Educational attainment (years of education); LUSC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg20243544 chr17:37824526 PNMT 0.5 7.04 0.36 1.09e-11 Asthma; LUSC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg19346786 chr7:2764209 NA -0.4 -7.01 -0.36 1.36e-11 Height; LUSC cis rs2832077 0.943 rs2832099 chr21:30173460 A/G cg08807101 chr21:30365312 RNF160 -0.51 -6.63 -0.34 1.32e-10 Cognitive test performance; LUSC trans rs2204008 0.748 rs11180579 chr12:38237830 A/G cg06521331 chr12:34319734 NA -0.39 -5.95 -0.31 6.67e-9 Bladder cancer; LUSC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg05472934 chr7:22766657 IL6 0.5 7.8 0.39 7.86e-14 Lung cancer; LUSC cis rs253664 1.000 rs253664 chr3:138113353 A/G cg25188949 chr3:137893707 DBR1 -0.47 -5.82 -0.3 1.38e-8 Body mass index; LUSC cis rs950027 0.596 rs2467865 chr15:45638307 T/C cg21132104 chr15:45694354 SPATA5L1 0.41 6.04 0.31 4.09e-9 Response to fenofibrate (adiponectin levels); LUSC trans rs1325195 0.734 rs2791942 chr1:179108081 A/G cg11624085 chr17:8464688 MYH10 0.42 6.96 0.36 1.78e-11 IgE grass sensitization; LUSC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg04414720 chr1:150670196 GOLPH3L 0.55 9.02 0.44 1.56e-17 Tonsillectomy; LUSC cis rs11577318 0.579 rs58034207 chr1:26683575 C/T cg00852783 chr1:26633632 UBXN11 -0.5 -7.01 -0.36 1.31e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs10927875 0.619 rs7546589 chr1:16129530 A/G cg22431228 chr1:16359049 CLCNKA 0.31 6.19 0.32 1.76e-9 Dilated cardiomyopathy; LUSC cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs1728785 1.000 rs11648314 chr16:68596775 A/G cg02508848 chr16:68573721 ZFP90 -0.44 -5.66 -0.3 3.27e-8 Ulcerative colitis; LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg18538332 chr22:24372958 LOC391322 -0.37 -6.53 -0.34 2.4e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg03146154 chr1:46216737 IPP 0.51 7.73 0.39 1.28e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3812762 0.826 rs2292045 chr11:8806709 G/T cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -6.41 -0.33 4.84e-10 Hypospadias; LUSC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg05802129 chr4:122689817 NA -0.37 -6.56 -0.34 2.06e-10 Type 2 diabetes; LUSC cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg22782873 chr19:19639568 YJEFN3 -0.48 -6.11 -0.32 2.7e-9 Bipolar disorder; LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC cis rs9472414 0.510 rs609643 chr6:44705303 A/G cg20913747 chr6:44695427 NA -0.39 -5.9 -0.31 8.87e-9 Height; LUSC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg15445000 chr17:37608096 MED1 0.33 5.99 0.31 5.3300000000000004e-09 Glomerular filtration rate (creatinine); LUSC cis rs6754311 0.551 rs2304599 chr2:136528004 C/G cg07169764 chr2:136633963 MCM6 -0.74 -10.01 -0.48 8.55e-21 Mosquito bite size; LUSC cis rs921968 0.541 rs576901 chr2:219424364 A/G cg02176678 chr2:219576539 TTLL4 0.74 14.82 0.63 1.58e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs2979489 0.891 rs2979504 chr8:30386641 C/T cg26383811 chr8:30366931 RBPMS -0.51 -8.14 -0.41 7.96e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.69 -9.09 -0.45 8.97e-18 Gut microbiome composition (summer); LUSC cis rs6489882 0.867 rs6489877 chr12:113368079 A/G cg20102336 chr12:113376681 OAS3 -0.4 -5.74 -0.3 2.17e-8 Chronic lymphocytic leukemia; LUSC cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg08999081 chr20:33150536 PIGU 0.42 7.21 0.37 3.87e-12 Coronary artery disease; LUSC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg17366294 chr4:99064904 C4orf37 0.6 10.44 0.5 2.76e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.930 rs6723148 chr2:15592019 G/T cg19274914 chr2:15703543 NA 0.46 9.01 0.44 1.66e-17 Educational attainment (years of education); LUSC cis rs734999 0.588 rs876938 chr1:2523212 G/C cg18932078 chr1:2524107 MMEL1 0.33 7.16 0.36 5.3e-12 Ulcerative colitis; LUSC cis rs11229555 1.000 rs12808544 chr11:58373221 C/A cg15696309 chr11:58395628 NA -0.7 -9.29 -0.45 2.07e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs7829975 0.533 rs13274028 chr8:8729193 A/C cg21775007 chr8:11205619 TDH 0.46 6.62 0.34 1.41e-10 Mood instability; LUSC cis rs36051895 0.589 rs6476946 chr9:5195275 C/G cg02405213 chr9:5042618 JAK2 0.51 7.17 0.37 4.92e-12 Pediatric autoimmune diseases; LUSC cis rs9646954 0.542 rs4149510 chr2:101023635 G/A cg12002119 chr2:101014098 CHST10 0.36 5.93 0.31 7.72e-9 Intelligence (multi-trait analysis); LUSC cis rs7107174 1.000 rs1893447 chr11:77973182 A/G cg02023728 chr11:77925099 USP35 0.47 6.93 0.35 2.21e-11 Testicular germ cell tumor; LUSC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.7 0.51 3.61e-23 Homoarginine levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16440638 chr2:11887120 LPIN1 -0.41 -6.14 -0.32 2.39e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9527 0.615 rs7917295 chr10:104701187 A/G cg05855489 chr10:104503620 C10orf26 0.53 8.2 0.41 5.35e-15 Arsenic metabolism; LUSC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg17971929 chr21:40555470 PSMG1 -0.68 -11.28 -0.53 3.18e-25 Cognitive function; LUSC cis rs3743266 0.593 rs4775276 chr15:60806185 C/T cg21667061 chr15:60772094 NARG2 0.37 6.11 0.32 2.7e-9 Menarche (age at onset); LUSC cis rs9399135 0.967 rs9389261 chr6:135371148 C/G cg24558204 chr6:135376177 HBS1L 0.57 8.77 0.43 9.11e-17 Red blood cell count; LUSC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg05084668 chr3:125655381 ALG1L -0.47 -6.65 -0.34 1.22e-10 Blood pressure (smoking interaction); LUSC cis rs34779708 0.931 rs11010130 chr10:35513307 T/C cg03585969 chr10:35415529 CREM 0.64 9.52 0.46 3.56e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12579753 1.000 rs12830268 chr12:82233627 A/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs17780086 0.529 rs7406406 chr17:30220153 T/G cg00745463 chr17:30367425 LRRC37B -0.46 -6.32 -0.33 8.15e-10 Height; LUSC trans rs8073060 0.505 rs225276 chr17:33973034 T/C cg19694781 chr19:47549865 TMEM160 -1.14 -17.81 -0.7 2.27e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.81 -15.27 -0.64 2.78e-40 Prudent dietary pattern; LUSC cis rs262150 0.579 rs4909110 chr7:158787332 C/T cg19418458 chr7:158789849 NA 0.52 6.68 0.34 1.01e-10 Facial morphology (factor 20); LUSC cis rs11229555 0.609 rs34133416 chr11:58184720 T/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg27535305 chr1:53392650 SCP2 0.36 6.71 0.34 8.29e-11 Monocyte count; LUSC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg20399509 chr21:47717575 C21orf57 -0.43 -6.29 -0.33 9.7e-10 Testicular germ cell tumor; LUSC cis rs1538970 1.000 rs1417578 chr1:45850590 A/G cg05343316 chr1:45956843 TESK2 0.6 8.57 0.42 3.93e-16 Platelet count; LUSC cis rs7177699 0.557 rs72749206 chr15:79122948 G/A cg15571903 chr15:79123663 NA -0.33 -5.94 -0.31 7.06e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg06697600 chr4:7070879 GRPEL1 -0.4 -6.61 -0.34 1.55e-10 Monocyte percentage of white cells; LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg18402987 chr7:1209562 NA 0.71 7.53 0.38 4.64e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg14895029 chr7:2775587 GNA12 -0.38 -6.1 -0.32 2.86e-9 Height; LUSC cis rs208520 0.874 rs208491 chr6:66928459 C/G cg07460842 chr6:66804631 NA -1.03 -14.29 -0.62 1.74e-36 Exhaled nitric oxide output; LUSC cis rs4595586 0.545 rs7967931 chr12:39375162 A/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC trans rs2228479 0.850 rs17226666 chr16:89835401 G/A cg24644049 chr4:85504048 CDS1 0.9 7.72 0.39 1.39e-13 Skin colour saturation; LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -5.99 -0.31 5.57e-9 Developmental language disorder (linguistic errors); LUSC cis rs240764 0.853 rs2062635 chr6:101002659 G/A cg09795085 chr6:101329169 ASCC3 -0.41 -5.9 -0.31 9.04e-9 Neuroticism; LUSC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.78 9.98 0.48 1.08e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10489525 0.560 rs10858062 chr1:115602563 A/G cg17147537 chr1:115611705 TSPAN2 0.29 5.98 0.31 5.77e-9 Autism; LUSC trans rs1728785 1.000 rs1170445 chr16:68573064 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs469568 0.543 rs12153128 chr5:178668714 A/G cg08999896 chr5:178685787 ADAMTS2 -0.36 -7.18 -0.37 4.6e-12 Stroke (pediatric); LUSC cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg27446573 chr6:127587934 RNF146 0.84 13.51 0.59 1.72e-33 Breast cancer; LUSC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg06238570 chr21:40685208 BRWD1 0.48 7.49 0.38 6.36e-13 Cognitive function; LUSC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg07716408 chr11:68623521 NA -0.32 -6.16 -0.32 2.1e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.8 14.42 0.62 5.58e-37 Total body bone mineral density; LUSC cis rs7094131 0.523 rs10764343 chr10:22882655 G/C cg19500236 chr10:22911537 PIP4K2A 0.35 6.24 0.32 1.31e-9 Obesity-related traits; LUSC cis rs9868809 0.505 rs28657585 chr3:48736216 A/T cg00383909 chr3:49044727 WDR6 1.16 10.81 0.51 1.45e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg20090143 chr19:45452003 APOC2 0.47 9.14 0.45 6.27e-18 Blood protein levels; LUSC cis rs35995292 0.500 rs8180877 chr7:38931258 G/A cg19327137 chr7:38886074 VPS41 0.55 10.26 0.49 1.18e-21 Subjective well-being (multi-trait analysis); LUSC cis rs7772486 0.875 rs2748502 chr6:146298239 A/G cg23711669 chr6:146136114 FBXO30 0.85 15.21 0.64 4.62e-40 Lobe attachment (rater-scored or self-reported); LUSC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg21775007 chr8:11205619 TDH -0.45 -6.6 -0.34 1.57e-10 Neuroticism; LUSC cis rs6690583 0.623 rs2083283 chr1:85439996 C/A cg11262906 chr1:85462892 MCOLN2 0.69 6.69 0.34 9.24e-11 Serum sulfate level; LUSC cis rs79349575 0.594 rs1985785 chr17:46967788 T/C cg22482690 chr17:47019901 SNF8 0.4 7.47 0.38 6.92e-13 Type 2 diabetes; LUSC trans rs11662586 0.517 rs11662894 chr18:77713591 G/A cg05926928 chr17:57297772 GDPD1 0.6 9.25 0.45 2.77e-18 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg22823121 chr1:150693482 HORMAD1 0.5 7.21 0.37 3.67e-12 Melanoma; LUSC cis rs597583 0.806 rs1940039 chr11:117393102 C/T cg27161313 chr11:117392002 DSCAML1 -0.43 -7.32 -0.37 1.85e-12 Putamen volume; LUSC cis rs62400317 0.859 rs17209636 chr6:45142517 T/G cg20913747 chr6:44695427 NA -0.47 -7.55 -0.38 4.28e-13 Total body bone mineral density; LUSC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg16797656 chr11:68205561 LRP5 -0.43 -7.86 -0.4 5.26e-14 Total body bone mineral density; LUSC cis rs6500602 0.727 rs8051389 chr16:4570570 C/T cg08645402 chr16:4508243 NA 0.54 9.13 0.45 6.81e-18 Schizophrenia; LUSC cis rs6426558 0.537 rs7523167 chr1:227365304 G/A cg10327440 chr1:227177885 CDC42BPA -0.53 -7.32 -0.37 1.91e-12 Neutrophil percentage of white cells; LUSC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg18876405 chr7:65276391 NA -0.75 -13.58 -0.6 9.72e-34 Calcium levels; LUSC cis rs2274273 0.870 rs3783650 chr14:55848972 A/C cg04306507 chr14:55594613 LGALS3 0.56 12.83 0.57 6.51e-31 Protein biomarker; LUSC cis rs7582180 0.627 rs4149517 chr2:101014247 C/A cg12002119 chr2:101014098 CHST10 0.37 6.17 0.32 1.99e-9 Intelligence (multi-trait analysis); LUSC cis rs9790314 0.846 rs6441371 chr3:161008727 C/A cg03342759 chr3:160939853 NMD3 -0.52 -8.77 -0.43 9.03e-17 Morning vs. evening chronotype; LUSC cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.16 0.55 2.03e-28 Motion sickness; LUSC cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg22508957 chr16:3507546 NAT15 0.42 6.1 0.32 2.93e-9 Body mass index (adult); LUSC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.49 -0.33 3.17e-10 Extrinsic epigenetic age acceleration; LUSC cis rs908922 0.676 rs11584191 chr1:152500428 A/T cg20991723 chr1:152506922 NA -0.47 -8.42 -0.42 1.09e-15 Hair morphology; LUSC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs2463822 0.925 rs1881535 chr11:62121623 C/T cg06239285 chr11:62104954 ASRGL1 0.98 10.97 0.51 4.05e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3740713 1.000 rs73440634 chr11:18473546 T/A cg07915343 chr11:18477680 LDHAL6A -0.56 -7.08 -0.36 8.47e-12 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6977660 0.943 rs10227692 chr7:19850199 T/C cg05791153 chr7:19748676 TWISTNB 0.5 5.68 0.3 2.89e-8 Thyroid stimulating hormone; LUSC cis rs7582180 0.663 rs10199518 chr2:100946041 G/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.59 -0.43 3.4e-16 Intelligence (multi-trait analysis); LUSC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg06212747 chr3:49208901 KLHDC8B 0.45 6.07 0.32 3.45e-9 Parkinson's disease; LUSC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg19077165 chr18:44547161 KATNAL2 -0.4 -5.99 -0.31 5.36e-9 Personality dimensions; LUSC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg07936489 chr17:37558343 FBXL20 -0.73 -10.0 -0.48 8.94e-21 Glomerular filtration rate (creatinine); LUSC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg13939156 chr17:80058883 NA -0.34 -6.73 -0.35 7.53e-11 Life satisfaction; LUSC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg06637938 chr14:75390232 RPS6KL1 0.53 8.42 0.42 1.11e-15 Height; LUSC trans rs1499614 1.000 rs2659913 chr7:66157336 T/A cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg06060754 chr5:176797920 RGS14 0.61 9.67 0.47 1.14e-19 Hemoglobin concentration;Hematocrit; LUSC cis rs9467711 0.524 rs13216484 chr6:26762087 C/T cg09904177 chr6:26538194 HMGN4 -0.76 -5.7 -0.3 2.63e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.37 0.42 1.64e-15 Colorectal cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20703240 chr5:177659585 AGXT2L2 -0.41 -5.99 -0.31 5.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs71435601 0.657 rs12712923 chr2:21421782 C/A cg20757404 chr19:378427 NA -0.41 -6.32 -0.33 8.46e-10 Cholesterol, total; LUSC trans rs7613875 0.620 rs7624030 chr3:50071279 A/C cg21659725 chr3:3221576 CRBN -0.54 -8.62 -0.43 2.78e-16 Body mass index; LUSC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg09455208 chr3:40491958 NA 0.59 10.68 0.5 4.25e-23 Renal cell carcinoma; LUSC cis rs4363385 0.510 rs6693927 chr1:153044009 G/A cg25856811 chr1:152973957 SPRR3 -0.38 -6.23 -0.32 1.43e-9 Inflammatory skin disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12447188 chr16:4743522 NUDT16L1 0.42 6.02 0.31 4.55e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4964805 0.913 rs12830701 chr12:104201682 A/C cg02344784 chr12:104178138 NT5DC3 0.43 6.96 0.36 1.85e-11 Attention deficit hyperactivity disorder; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T ch.2.3405933F chr2:168679352 B3GALT1 0.41 6.02 0.31 4.7e-9 Mosquito bite size; LUSC cis rs73200209 0.744 rs2304460 chr12:116408538 A/G cg01776926 chr12:116560359 MED13L -0.52 -5.89 -0.31 9.19e-9 Total body bone mineral density; LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg20887711 chr4:1340912 KIAA1530 0.44 6.53 0.34 2.48e-10 Obesity-related traits; LUSC cis rs4919694 1.000 rs12257935 chr10:104803062 C/A cg04362960 chr10:104952993 NT5C2 1.18 13.93 0.61 4.45e-35 Arsenic metabolism; LUSC cis rs6076065 0.755 rs3746734 chr20:23349765 C/T cg11657817 chr20:23433608 CST11 0.42 7.83 0.39 6.47e-14 Facial morphology (factor 15, philtrum width); LUSC trans rs1927790 0.727 rs6491285 chr13:96944930 T/A cg03198741 chr6:1003969 LOC285768 -0.39 -6.04 -0.31 4.21e-9 Body mass index; LUSC cis rs4805272 0.512 rs765484 chr19:29344663 A/G cg12756686 chr19:29218302 NA 0.57 6.35 0.33 7.04e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg00933542 chr6:150070202 PCMT1 0.3 6.0 0.31 5.27e-9 Lung cancer; LUSC trans rs6502050 0.723 rs11650633 chr17:80083807 T/C cg07393940 chr7:158741817 NA -0.38 -6.75 -0.35 6.48e-11 Life satisfaction; LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg22907277 chr7:1156413 C7orf50 0.48 7.27 0.37 2.6e-12 Longevity;Endometriosis; LUSC cis rs546131 0.928 rs558967 chr11:34827168 T/A cg11058730 chr11:34937778 PDHX;APIP 0.43 5.77 0.3 1.79e-8 Lung disease severity in cystic fibrosis; LUSC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.66 0.34 1.15e-10 Menopause (age at onset); LUSC cis rs2190422 0.677 rs2382693 chr7:103076969 A/G cg04218035 chr7:103086829 SLC26A5 -0.32 -6.21 -0.32 1.61e-9 Morning vs. evening chronotype; LUSC cis rs9354308 0.901 rs55832318 chr6:66560086 A/G cg07460842 chr6:66804631 NA 0.48 5.91 0.31 8.42e-9 Metabolite levels; LUSC cis rs9902453 0.874 rs62070271 chr17:28268358 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.79 0.51 1.7e-23 Coffee consumption (cups per day); LUSC cis rs2637266 0.628 rs846632 chr10:78535759 C/A cg18941641 chr10:78392320 NA 0.39 7.12 0.36 6.58e-12 Pulmonary function; LUSC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg16339924 chr4:17578868 LAP3 0.55 8.38 0.42 1.46e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12618769 0.625 rs12618524 chr2:99064029 T/A cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs9300255 0.602 rs1790116 chr12:123618544 G/T cg00376283 chr12:123451042 ABCB9 0.66 8.29 0.41 2.85e-15 Neutrophil percentage of white cells; LUSC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg23625390 chr15:77176239 SCAPER -0.42 -6.43 -0.33 4.54e-10 Blood metabolite levels; LUSC cis rs4820539 0.611 rs28451783 chr22:23488569 G/T cg14186256 chr22:23484241 RTDR1 0.76 11.78 0.54 4.86e-27 Bone mineral density; LUSC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.18 0.52 7.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1322512 0.917 rs2758805 chr6:152959301 A/G cg27316956 chr6:152958899 SYNE1 -0.37 -6.2 -0.32 1.62e-9 Tonometry; LUSC cis rs11039100 1.000 rs1470872 chr11:5827540 T/C cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs7618501 0.602 rs2071206 chr3:50160109 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -8.63 -0.43 2.5e-16 Intelligence (multi-trait analysis); LUSC trans rs2039659 0.719 rs1538049 chr13:86276135 A/G cg22803222 chr6:76636725 IMPG1 0.37 6.04 0.31 4.15e-9 Blood osmolality (transformed sodium); LUSC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg05729581 chr11:3078854 CARS -0.57 -8.5 -0.42 6.58e-16 Longevity; LUSC trans rs3942852 0.806 rs10769317 chr11:48150712 T/C cg03929089 chr4:120376271 NA -0.58 -7.05 -0.36 1.02e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs5167 0.566 rs2075620 chr19:45480037 C/T cg10169327 chr19:45448959 APOC2 -0.3 -5.73 -0.3 2.29e-8 Blood protein levels; LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.16 0.61 5.72e-36 Platelet count; LUSC cis rs7119038 0.818 rs73003215 chr11:118649512 G/A cg19308663 chr11:118741387 NA 0.36 6.38 0.33 5.85e-10 Sjögren's syndrome; LUSC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg12751644 chr20:60527061 NA -0.33 -5.91 -0.31 8.33e-9 Body mass index; LUSC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg23985595 chr17:80112537 CCDC57 -0.31 -5.91 -0.31 8.39e-9 Life satisfaction; LUSC trans rs2832191 0.740 rs13048618 chr21:30458684 A/G cg14791747 chr16:20752902 THUMPD1 -0.41 -6.17 -0.32 1.97e-9 Dental caries; LUSC cis rs7759001 0.857 rs10946914 chr6:27369892 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg26441486 chr22:50317300 CRELD2 0.48 7.07 0.36 9.37e-12 Schizophrenia; LUSC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg00677455 chr12:58241039 CTDSP2 0.54 6.91 0.35 2.4e-11 Multiple sclerosis; LUSC cis rs72634258 0.945 rs161802 chr1:8042826 G/T cg00042356 chr1:8021962 PARK7 0.64 8.37 0.42 1.65e-15 Inflammatory bowel disease; LUSC cis rs9612 1.000 rs346544 chr19:44256205 A/G cg08581076 chr19:44259116 C19orf61 0.51 6.43 0.33 4.38e-10 Exhaled nitric oxide output; LUSC cis rs870825 0.698 rs66462315 chr4:185623917 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs1559088 0.501 rs8100568 chr19:33567565 T/C cg17764715 chr19:33622953 WDR88 0.6 6.69 0.34 9.28e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs71403859 0.504 rs35203704 chr16:71959661 G/A cg08717414 chr16:71523259 ZNF19 -0.56 -5.76 -0.3 1.87e-8 Post bronchodilator FEV1; LUSC trans rs656319 0.605 rs60278284 chr8:10003210 G/C cg21775007 chr8:11205619 TDH -0.45 -6.25 -0.32 1.26e-9 Myopia (pathological); LUSC cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg24642439 chr20:33292090 TP53INP2 0.48 7.23 0.37 3.41e-12 Glomerular filtration rate (creatinine); LUSC cis rs7264396 0.563 rs11698796 chr20:34248134 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -8.44 -0.42 9.63e-16 Total cholesterol levels; LUSC cis rs10464366 1.000 rs10951593 chr7:39121390 C/T cg20302533 chr7:39170763 POU6F2 0.41 6.23 0.32 1.41e-9 IgG glycosylation; LUSC cis rs10875746 0.903 rs989144 chr12:48483973 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg00376283 chr12:123451042 ABCB9 0.68 8.6 0.43 3.1e-16 Neutrophil percentage of white cells; LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 6.01 0.31 4.91e-9 Menopause (age at onset); LUSC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.38 0.46 1.01e-18 Monocyte percentage of white cells; LUSC cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg00504896 chr12:9437009 LOC642846 -0.48 -7.63 -0.39 2.41e-13 Breast size; LUSC cis rs67460515 0.563 rs13071892 chr3:160817877 A/C cg03342759 chr3:160939853 NMD3 -0.45 -6.09 -0.32 3.1e-9 Parkinson's disease; LUSC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg16423285 chr20:60520624 NA -0.47 -5.92 -0.31 8.15e-9 Body mass index; LUSC trans rs9747201 0.963 rs4789729 chr17:80146089 G/A cg07393940 chr7:158741817 NA 0.54 8.76 0.43 1.03e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2354432 0.556 rs72710311 chr1:146698256 A/G cg25205988 chr1:146714368 CHD1L -0.99 -8.71 -0.43 1.43e-16 Mitochondrial DNA levels; LUSC cis rs11622475 1.000 rs34964872 chr14:104448435 T/A cg12183467 chr14:104352244 NA -0.42 -7.49 -0.38 6.22e-13 Bipolar disorder; LUSC cis rs1878931 0.580 rs3848355 chr16:3407489 A/C cg22508957 chr16:3507546 NAT15 -0.37 -6.11 -0.32 2.7e-9 Body mass index (adult); LUSC cis rs8060686 0.546 rs8047978 chr16:68143598 T/G cg05110241 chr16:68378359 PRMT7 -0.44 -5.89 -0.31 9.24e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs253664 0.897 rs1199336 chr3:138088221 T/A cg25188949 chr3:137893707 DBR1 -0.5 -5.94 -0.31 7.29e-9 Body mass index; LUSC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg17366294 chr4:99064904 C4orf37 0.57 9.97 0.48 1.14e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs3770081 1.000 rs73947314 chr2:86273116 T/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.51 -0.34 2.82e-10 Facial emotion recognition (sad faces); LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg03354898 chr7:1950403 MAD1L1 -0.33 -6.4 -0.33 5.37e-10 Bipolar disorder and schizophrenia; LUSC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.62 7.69 0.39 1.69e-13 Lung function (FEV1/FVC); LUSC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg09367891 chr1:107599246 PRMT6 0.48 7.68 0.39 1.83e-13 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs447735 0.587 rs258335 chr16:89720944 G/A cg03605463 chr16:89740564 NA 0.53 8.26 0.41 3.41e-15 Hemoglobin concentration; LUSC cis rs6430585 0.528 rs721765 chr2:136748779 C/A cg07169764 chr2:136633963 MCM6 1.13 17.53 0.69 2.98e-49 Corneal structure; LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg24675658 chr1:53192096 ZYG11B 0.58 9.11 0.45 7.92e-18 Monocyte count; LUSC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.66 -6.43 -0.33 4.49e-10 Cerebrospinal P-tau181p levels; LUSC cis rs7119 0.634 rs2682922 chr15:77865006 A/C cg27398640 chr15:77910606 LINGO1 0.36 7.96 0.4 2.67e-14 Type 2 diabetes; LUSC cis rs7851660 0.874 rs1955144 chr9:100634589 A/G cg13688889 chr9:100608707 NA -0.56 -8.94 -0.44 2.78e-17 Strep throat; LUSC trans rs7937682 0.883 rs659529 chr11:111436896 T/A cg18187862 chr3:45730750 SACM1L 0.6 7.68 0.39 1.72e-13 Primary sclerosing cholangitis; LUSC cis rs2294693 0.947 rs4714417 chr6:40987782 A/G cg14769373 chr6:40998127 UNC5CL -0.56 -8.12 -0.41 8.99e-15 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg27170947 chr2:26402098 FAM59B -0.65 -9.7 -0.47 9.25e-20 Gut microbiome composition (summer); LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg22638593 chr5:131593259 PDLIM4 0.42 6.07 0.32 3.45e-9 Acylcarnitine levels; LUSC cis rs67072384 1.000 rs67809272 chr11:72450941 T/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.4e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg11764359 chr7:65958608 NA 0.81 13.54 0.6 1.31e-33 Aortic root size; LUSC cis rs2637266 0.935 rs4353214 chr10:78393149 C/T cg18941641 chr10:78392320 NA -0.41 -7.51 -0.38 5.41e-13 Pulmonary function; LUSC trans rs561341 1.000 rs497479 chr17:30328605 C/T cg20587970 chr11:113659929 NA -1.28 -18.08 -0.7 1.91e-51 Hip circumference adjusted for BMI; LUSC cis rs1113500 0.548 rs11185269 chr1:108647636 T/C cg06207961 chr1:108661230 NA 0.35 5.74 0.3 2.17e-8 Growth-regulated protein alpha levels; LUSC cis rs9311676 0.618 rs62258135 chr3:58403330 C/T cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC trans rs17039065 0.920 rs58424294 chr4:109420427 C/T cg07444054 chr2:108107501 NA 0.45 6.29 0.33 1.01e-9 Gut microbiome composition (summer); LUSC cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.68 0.3 2.92e-8 Schizophrenia; LUSC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.46 7.02 0.36 1.28e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7582180 0.629 rs4851298 chr2:100949827 G/A cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg16325326 chr1:53192061 ZYG11B 0.85 15.13 0.64 9.25e-40 Monocyte count; LUSC cis rs7107174 1.000 rs1006441 chr11:77932126 G/C cg02023728 chr11:77925099 USP35 0.5 7.11 0.36 7.17e-12 Testicular germ cell tumor; LUSC cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg04586622 chr2:25135609 ADCY3 0.32 6.18 0.32 1.92e-9 Body mass index; LUSC cis rs1775715 0.737 rs2151047 chr10:32102110 G/A cg18675610 chr10:32216311 ARHGAP12 0.31 6.58 0.34 1.8e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.78 0.6 1.67e-34 Chronic sinus infection; LUSC cis rs7075426 0.669 rs4934220 chr10:88288206 A/G cg07322936 chr10:88137208 NA -0.45 -6.53 -0.34 2.45e-10 Migraine without aura; LUSC cis rs523522 0.962 rs603574 chr12:120998443 A/G cg12219531 chr12:120966889 COQ5 0.63 8.57 0.42 3.93e-16 High light scatter reticulocyte count; LUSC cis rs4400599 0.901 rs2494671 chr1:154100779 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 0.37 6.01 0.31 4.87e-9 Platelet distribution width; LUSC cis rs7113850 0.541 rs75347910 chr11:24213815 G/A ch.11.24196551F chr11:24239977 NA 0.97 7.41 0.38 1.05e-12 Bone fracture in osteoporosis; LUSC cis rs854765 0.583 rs8070128 chr17:17804725 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.75 -12.83 -0.57 6.33e-31 Total body bone mineral density; LUSC cis rs56283067 0.887 rs10948171 chr6:44761028 C/T cg20913747 chr6:44695427 NA -0.49 -7.55 -0.38 4.27e-13 Total body bone mineral density; LUSC cis rs56161922 0.818 rs4437879 chr1:207875977 G/A cg11752769 chr1:207818423 CR1L -0.71 -5.93 -0.31 7.62e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg11279151 chr3:101281821 RG9MTD1 -0.42 -5.89 -0.31 9.46e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg00012203 chr2:219082015 ARPC2 0.87 16.15 0.66 9.37e-44 Colorectal cancer; LUSC cis rs4363385 0.693 rs582345 chr1:153033406 G/A cg00922841 chr1:152955080 SPRR1A -0.42 -7.2 -0.37 4.13e-12 Inflammatory skin disease; LUSC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC cis rs4803468 1.000 rs2241708 chr19:41912270 C/T cg09537434 chr19:41945824 ATP5SL -0.89 -15.75 -0.65 3.38e-42 Height; LUSC cis rs709400 0.663 rs62007718 chr14:103940436 G/A cg12935359 chr14:103987150 CKB -0.57 -8.83 -0.44 5.8e-17 Body mass index; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg10862848 chr6:42927986 GNMT -0.28 -6.73 -0.35 7.26e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9653442 0.648 rs6733895 chr2:100666082 C/G cg07810366 chr2:100720526 AFF3 -0.44 -7.34 -0.37 1.66e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg10802521 chr3:52805072 NEK4 -0.55 -8.68 -0.43 1.83e-16 Bipolar disorder; LUSC cis rs983392 0.805 rs7926729 chr11:59961786 C/T cg20284999 chr11:59952153 MS4A6A -0.39 -6.39 -0.33 5.55e-10 Alzheimer's disease (late onset); LUSC cis rs5769707 0.935 rs739239 chr22:50050468 G/A cg01652190 chr22:50026171 C22orf34 -0.31 -6.25 -0.32 1.24e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3617 0.573 rs4687682 chr3:52916939 T/C cg18099408 chr3:52552593 STAB1 0.37 6.17 0.32 1.93e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs240764 0.717 rs6907444 chr6:101163606 G/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.08 -0.32 3.25e-9 Neuroticism; LUSC cis rs56804039 1.000 rs17616779 chr8:8382374 A/G cg15556689 chr8:8085844 FLJ10661 0.59 7.73 0.39 1.29e-13 Cervical cancer; LUSC cis rs9287719 0.967 rs2110778 chr2:10748970 A/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg02167203 chr6:41068553 NFYA;LOC221442 0.4 5.98 0.31 5.89e-9 Alzheimer's disease (late onset); LUSC cis rs11031096 0.678 rs61899754 chr11:4201312 A/T cg18678763 chr11:4115507 RRM1 -0.41 -5.77 -0.3 1.85e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs765787 0.530 rs4774542 chr15:45526026 A/C cg24006582 chr15:45444508 DUOX1 0.57 8.17 0.41 6.5e-15 Uric acid levels; LUSC cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 0.35 6.14 0.32 2.31e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9393777 0.720 rs56874662 chr6:26985607 C/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.54 -6.36 -0.33 6.81e-10 Intelligence (multi-trait analysis); LUSC cis rs9326248 0.559 rs10892052 chr11:116834313 G/A cg01368799 chr11:117014884 PAFAH1B2 0.6 9.19 0.45 4.26e-18 Blood protein levels; LUSC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg27165867 chr14:105738592 BRF1 -0.52 -7.65 -0.39 2.17e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs7608623 0.773 rs11679039 chr2:23921565 A/C cg08917208 chr2:24149416 ATAD2B -0.42 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs5769707 0.521 rs5769719 chr22:50062101 G/A cg20744362 chr22:50050164 C22orf34 0.35 6.29 0.33 9.69e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.2 0.37 4.08e-12 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg05340658 chr4:99064831 C4orf37 0.63 10.91 0.51 6.56e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1387259 0.929 rs11168460 chr12:48597365 A/G cg04545296 chr12:48745243 ZNF641 0.33 6.21 0.32 1.57e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs644799 0.932 rs523934 chr11:95641775 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.83 14.34 0.62 1.16e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.08 0.36 8.38e-12 Platelet count; LUSC cis rs9300255 0.510 rs1727322 chr12:123699520 A/G cg13010344 chr12:123464640 ARL6IP4 -0.48 -5.9 -0.31 8.74e-9 Neutrophil percentage of white cells; LUSC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg07395648 chr5:131743802 NA 0.47 7.67 0.39 1.85e-13 Breast cancer;Mosquito bite size; LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg25019033 chr10:957182 NA -0.53 -6.95 -0.36 1.88e-11 Eosinophil percentage of granulocytes; LUSC cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg17173187 chr15:85201210 NMB 0.36 6.08 0.32 3.27e-9 Schizophrenia; LUSC cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC trans rs35110281 0.805 rs4818855 chr21:45038951 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.92 0.48 1.72e-20 Mean corpuscular volume; LUSC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg06238570 chr21:40685208 BRWD1 0.5 7.51 0.38 5.29e-13 Cognitive function; LUSC cis rs12681287 0.547 rs9942823 chr8:87509177 A/G cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs9902453 0.904 rs12103671 chr17:28408217 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.56 -0.5 1.13e-22 Coffee consumption (cups per day); LUSC cis rs7147624 1.000 rs7147624 chr14:65865625 G/T cg03016385 chr14:66212404 NA 0.8 9.57 0.46 2.54e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6977660 0.714 rs12666488 chr7:19788403 G/A cg07541023 chr7:19748670 TWISTNB 0.68 7.31 0.37 2.03e-12 Thyroid stimulating hormone; LUSC cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg11266682 chr4:10021025 SLC2A9 0.59 10.64 0.5 5.79e-23 Bone mineral density; LUSC cis rs4925386 0.959 rs4925385 chr20:60920624 A/G cg06026331 chr20:60912101 LAMA5 -0.42 -5.72 -0.3 2.41e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs9393777 0.623 rs7773938 chr6:26474044 C/T cg12292205 chr6:26970375 C6orf41 -0.63 -7.62 -0.38 2.66e-13 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.18e-11 Developmental language disorder (linguistic errors); LUSC cis rs67981189 0.574 rs2526884 chr14:71367967 G/A cg15816911 chr14:71606274 NA -0.32 -5.64 -0.3 3.55e-8 Schizophrenia; LUSC cis rs4629180 1.000 rs974374 chr2:102105846 C/T cg04415270 chr2:102091202 RFX8 0.58 9.66 0.47 1.27e-19 Chronic rhinosinusitis with nasal polyps; LUSC cis rs9653442 0.527 rs12712064 chr2:100756548 C/T cg22139774 chr2:100720529 AFF3 -0.42 -7.25 -0.37 3e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs12545109 0.800 rs1440746 chr8:57415912 G/A cg09654669 chr8:57350985 NA -0.58 -8.08 -0.4 1.18e-14 Obesity-related traits; LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03934478 chr11:495069 RNH1 0.86 9.78 0.47 5.09e-20 Body mass index; LUSC cis rs11098499 0.955 rs13129661 chr4:120152909 C/G cg24375607 chr4:120327624 NA 0.75 11.4 0.53 1.21e-25 Corneal astigmatism; LUSC cis rs7786808 0.552 rs2878456 chr7:158182129 A/T cg01191920 chr7:158217561 PTPRN2 -0.5 -10.29 -0.49 9.19e-22 Obesity-related traits; LUSC cis rs7715806 0.500 rs4703676 chr5:74979866 G/C cg19683494 chr5:74908142 NA 0.58 7.92 0.4 3.64e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.35 -0.33 6.84e-10 Total body bone mineral density; LUSC trans rs10435719 0.834 rs11250176 chr8:11792816 A/G cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.77e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs7819412 0.715 rs35223712 chr8:11043926 C/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.49 -0.33 3.15e-10 Triglycerides; LUSC cis rs710216 0.571 rs11210772 chr1:43448499 A/G cg03128534 chr1:43423976 SLC2A1 -0.44 -6.48 -0.33 3.27e-10 Red cell distribution width; LUSC cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -7.21 -0.37 3.8e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg01879757 chr17:41196368 BRCA1 -0.46 -7.03 -0.36 1.14e-11 Menopause (age at onset); LUSC cis rs62408225 1.000 rs62408224 chr6:90955995 A/G cg06866423 chr6:90926672 BACH2 0.41 5.86 0.31 1.08e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14591386 chr6:97345725 NDUFAF4 -0.44 -6.25 -0.32 1.25e-9 Hepatitis; LUSC cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.84 0.65 1.59e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs11250464 1.000 rs11250464 chr10:1406364 A/G cg08668359 chr10:1443807 ADARB2 0.41 6.23 0.32 1.43e-9 Radiation response; LUSC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -5.99 -0.31 5.34e-9 Total body bone mineral density; LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -6.13 -0.32 2.44e-9 Developmental language disorder (linguistic errors); LUSC cis rs2067615 0.524 rs10861646 chr12:107071182 C/T cg15890332 chr12:107067104 RFX4 0.36 6.33 0.33 7.72e-10 Heart rate; LUSC cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Bladder cancer; LUSC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.07 -0.32 3.51e-9 Alzheimer's disease (late onset); LUSC cis rs3772130 0.923 rs34865234 chr3:121560995 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.68 9.62 0.47 1.7e-19 Cognitive performance; LUSC cis rs1577917 0.917 rs35738006 chr6:86646309 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs2398893 0.924 rs1539282 chr9:96827424 T/C cg14459158 chr9:96720562 NA 0.32 6.07 0.32 3.52e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg11965913 chr1:205819406 PM20D1 -0.47 -7.26 -0.37 2.77e-12 Menarche (age at onset); LUSC cis rs7511006 1.000 rs7364173 chr22:50681029 C/T cg16473166 chr22:50639996 SELO -0.58 -8.11 -0.41 9.69e-15 Obesity-related traits; LUSC cis rs4812048 0.689 rs151357 chr20:57609055 A/G cg14073986 chr20:57617431 SLMO2 0.5 5.76 0.3 1.91e-8 Mean platelet volume; LUSC cis rs317865 0.737 rs73234644 chr4:16190661 T/G cg04764131 chr4:16228633 TAPT1;FLJ39653 0.61 5.83 0.3 1.3e-8 Kidney disease (early stage) in type 1 diabetes; LUSC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg25456477 chr12:86230367 RASSF9 0.44 7.87 0.4 4.98e-14 Major depressive disorder; LUSC cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg01849466 chr14:104193079 ZFYVE21 -0.59 -9.63 -0.47 1.6e-19 Schizophrenia; LUSC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.62 13.24 0.59 1.94e-32 Monocyte percentage of white cells; LUSC trans rs4596713 0.538 rs7029627 chr9:71745687 C/T cg25283916 chr1:242222868 NA -0.29 -6.04 -0.31 4.19e-9 Headache; LUSC cis rs9768139 0.935 rs62480865 chr7:158122307 A/C cg06219351 chr7:158114137 PTPRN2 0.51 9.13 0.45 6.75e-18 Calcium levels; LUSC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg18876405 chr7:65276391 NA -0.66 -11.66 -0.54 1.34e-26 Aortic root size; LUSC cis rs55675132 0.620 rs2335721 chr1:115637248 C/G cg01522456 chr1:115632236 TSPAN2 -0.44 -6.14 -0.32 2.39e-9 Schizophrenia; LUSC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.96 0.31 6.36e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9660992 0.649 rs12128254 chr1:205268097 C/T cg21545522 chr1:205238299 TMCC2 0.49 8.99 0.44 1.91e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg16586182 chr3:47516702 SCAP 0.58 8.98 0.44 2.03e-17 Colorectal cancer; LUSC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg12863693 chr15:85201151 NMB 0.35 6.85 0.35 3.61e-11 Schizophrenia; LUSC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.92 0.4 3.53e-14 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04174309 chr11:117102980 RNF214;PCSK7 0.42 6.58 0.34 1.78e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6456156 0.586 rs7742305 chr6:167485723 C/T cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.88e-11 Primary biliary cholangitis; LUSC cis rs932287 0.858 rs7109896 chr11:9054522 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.41 7.57 0.38 3.74e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7296418 0.663 rs11057284 chr12:123830692 G/C cg00376283 chr12:123451042 ABCB9 0.72 10.99 0.52 3.54e-24 Platelet count; LUSC cis rs11792861 0.781 rs2151426 chr9:111743797 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.32 0.41 2.34e-15 Menarche (age at onset); LUSC cis rs9300255 0.663 rs7953929 chr12:123758235 C/G cg00376283 chr12:123451042 ABCB9 0.65 7.24 0.37 3.19e-12 Neutrophil percentage of white cells; LUSC cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg19592336 chr6:28129416 ZNF389 0.45 5.94 0.31 7.18e-9 Depression; LUSC cis rs72634258 0.842 rs7545745 chr1:8165667 T/A cg26816564 chr1:7831052 VAMP3 -0.43 -5.81 -0.3 1.47e-8 Inflammatory bowel disease; LUSC cis rs2224391 0.628 rs6913120 chr6:5260505 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.46 -5.75 -0.3 2.02e-8 Height; LUSC trans rs8002861 0.935 rs1822969 chr13:44418164 G/A cg12856521 chr11:46389249 DGKZ 0.39 6.25 0.32 1.27e-9 Leprosy; LUSC cis rs61931739 0.890 rs814663 chr12:34106338 C/T cg06521331 chr12:34319734 NA -0.38 -6.33 -0.33 8.13e-10 Morning vs. evening chronotype; LUSC cis rs1800795 0.901 rs2069833 chr7:22767664 C/T cg01770232 chr7:22766155 IL6 0.4 5.76 0.3 1.93e-8 Cerebrospinal fluid clusterin levels in APOEe4- carriers; LUSC cis rs2130392 1.000 rs4862406 chr4:185629339 G/A cg04058563 chr4:185651563 MLF1IP -0.39 -6.36 -0.33 6.72e-10 Kawasaki disease; LUSC trans rs853679 0.607 rs34788973 chr6:27879200 C/A cg06606381 chr12:133084897 FBRSL1 -0.99 -8.56 -0.42 4.08e-16 Depression; LUSC cis rs2607426 0.681 rs2254326 chr19:41255889 G/T cg05508168 chr19:41255947 C19orf54;SNRPA 0.87 6.05 0.31 3.81e-9 Blood protein levels; LUSC cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs3931020 0.688 rs968358 chr1:75193989 G/T cg21906852 chr1:75198582 TYW3;CRYZ 0.45 5.82 0.3 1.37e-8 Resistin levels; LUSC cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.7 -0.39 1.58e-13 Mood instability; LUSC cis rs4730250 0.708 rs74983157 chr7:106823951 A/G cg02696742 chr7:106810147 HBP1 -0.64 -9.67 -0.47 1.2e-19 Osteoarthritis; LUSC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg06219351 chr7:158114137 PTPRN2 -0.54 -9.85 -0.47 2.89e-20 Calcium levels; LUSC cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.11 -0.45 7.57e-18 Monocyte percentage of white cells; LUSC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg12257692 chr3:49977190 RBM6 -0.25 -6.95 -0.36 1.96e-11 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs35123781 1.000 rs2336880 chr5:139063728 A/G cg10513866 chr5:139070639 NA -0.42 -8.37 -0.42 1.65e-15 Schizophrenia; LUSC cis rs113835537 1.000 rs113835537 chr11:66339639 A/G cg24851651 chr11:66362959 CCS 0.53 6.79 0.35 5.28e-11 Airway imaging phenotypes; LUSC cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.35 -5.8 -0.3 1.51e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs748404 0.697 rs471122 chr15:43558574 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.52 -8.29 -0.41 2.86e-15 Lung cancer; LUSC cis rs274567 0.599 rs11242110 chr5:131743777 A/C cg07395648 chr5:131743802 NA 0.56 8.98 0.44 2.07e-17 Blood metabolite levels; LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg10802521 chr3:52805072 NEK4 -0.47 -7.36 -0.37 1.44e-12 Bipolar disorder; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G ch.5.3315058R chr5:173165015 NA 0.43 6.11 0.32 2.72e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6076960 0.684 rs6054059 chr20:6262472 G/T cg17788362 chr6:86352627 SYNCRIP 0.5 7.57 0.38 3.79e-13 Smooth-surface caries; LUSC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg13770153 chr20:60521292 NA -0.65 -8.69 -0.43 1.68e-16 Body mass index; LUSC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg05425664 chr17:57184151 TRIM37 -0.52 -7.92 -0.4 3.46e-14 Intelligence (multi-trait analysis); LUSC cis rs4604732 0.536 rs12074913 chr1:247631607 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.87 0.35 3.13e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9487051 0.735 rs459956 chr6:109524760 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.74 -0.3 2.15e-8 Reticulocyte fraction of red cells; LUSC cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.63 9.97 0.48 1.15e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.02 -0.4 1.76e-14 Intelligence (multi-trait analysis); LUSC trans rs2431623 0.752 rs2431637 chr10:12875263 G/A cg08415853 chr5:87979005 LOC645323 -0.38 -6.09 -0.32 3.05e-9 Asymmetrical dimethylarginine levels; LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.89 0.61 6.08e-35 Platelet count; LUSC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg23436779 chr17:56769830 TEX14;RAD51C -0.46 -5.66 -0.3 3.27e-8 Cognitive test performance; LUSC cis rs6541297 0.645 rs4846920 chr1:230301574 A/G cg05784532 chr1:230284198 GALNT2 0.52 6.16 0.32 2.07e-9 Coronary artery disease; LUSC cis rs3845702 0.736 rs259810 chr2:180787821 T/C cg01881094 chr2:180872142 CWC22 -0.96 -10.83 -0.51 1.28e-23 Schizophrenia; LUSC cis rs2952156 0.959 rs2952151 chr17:37828496 T/C cg00129232 chr17:37814104 STARD3 -0.43 -6.31 -0.33 8.92e-10 Asthma; LUSC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg07211511 chr3:129823064 LOC729375 -1.24 -20.31 -0.74 2.85e-60 Blood pressure (smoking interaction); LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg18404041 chr3:52824283 ITIH1 -0.58 -11.23 -0.52 4.74e-25 Bipolar disorder; LUSC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg17252645 chr8:143867129 LY6D 0.54 10.24 0.49 1.38e-21 Urinary tract infection frequency; LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -7.29 -0.37 2.26e-12 Renal function-related traits (BUN); LUSC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg16447950 chr5:562315 NA -0.57 -6.95 -0.36 1.97e-11 Lung disease severity in cystic fibrosis; LUSC trans rs7493 0.950 rs7785846 chr7:95033841 C/T cg23291145 chr4:41648620 LIMCH1 -0.38 -5.97 -0.31 6.17e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs240764 0.717 rs180963 chr6:101127213 T/C cg09795085 chr6:101329169 ASCC3 0.4 5.83 0.3 1.34e-8 Neuroticism; LUSC cis rs3020736 0.500 rs6002614 chr22:42501802 G/A cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs4280164 0.551 rs3212260 chr14:24804088 A/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.62 -7.69 -0.39 1.67e-13 Parent of origin effect on language impairment (paternal); LUSC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg23281280 chr6:28129359 ZNF389 0.44 5.7 0.3 2.58e-8 Depression; LUSC cis rs12950390 0.853 rs11655112 chr17:45856563 T/C cg03474202 chr17:45855739 NA -0.29 -6.7 -0.34 8.99e-11 IgG glycosylation; LUSC trans rs11098499 0.863 rs3775854 chr4:120471971 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.63 0.34 1.33e-10 Corneal astigmatism; LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg22963979 chr7:1858916 MAD1L1 -0.73 -11.88 -0.54 2.22e-27 Autism spectrum disorder or schizophrenia; LUSC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg06145435 chr7:1022769 CYP2W1 0.38 6.71 0.34 8.34e-11 Bronchopulmonary dysplasia; LUSC cis rs11098499 0.775 rs67281037 chr4:120281157 G/C cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.94 -0.35 2.1e-11 Monocyte percentage of white cells; LUSC cis rs4380275 1.000 rs4854376 chr2:763683 A/T cg21665850 chr2:731073 NA 0.36 5.66 0.3 3.19e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC trans rs61931739 0.500 rs9795938 chr12:34587739 C/T cg26384229 chr12:38710491 ALG10B -0.79 -13.28 -0.59 1.33e-32 Morning vs. evening chronotype; LUSC cis rs4654899 1.000 rs10916937 chr1:21439785 A/G cg01072550 chr1:21505969 NA -0.53 -8.1 -0.41 1.06e-14 Superior frontal gyrus grey matter volume; LUSC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg22535103 chr8:58192502 C8orf71 -0.72 -7.42 -0.38 9.98e-13 Developmental language disorder (linguistic errors); LUSC cis rs7216064 0.906 rs1976052 chr17:65830578 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -8.56 -0.42 4.17e-16 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.25e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs995000 0.931 rs626787 chr1:62901243 C/G cg13009365 chr22:24093455 ZNF70 0.4 6.12 0.32 2.67e-9 Triglyceride levels; LUSC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg23283495 chr1:209979779 IRF6 0.68 7.91 0.4 3.77e-14 Cleft lip with or without cleft palate; LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg24503407 chr1:205819492 PM20D1 0.52 7.55 0.38 4.09e-13 Prostate-specific antigen levels; LUSC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.19 -0.49 2.08e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1018836 0.631 rs2205158 chr8:91472515 C/T cg16814680 chr8:91681699 NA -0.56 -8.24 -0.41 4.09e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs2739330 0.734 rs2000467 chr22:24241533 C/T cg06437703 chr8:37914619 EIF4EBP1 0.48 7.13 0.36 6.05e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11690935 0.959 rs13419987 chr2:172623914 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.37 -0.62 8.79e-37 Schizophrenia; LUSC cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg14664628 chr15:75095509 CSK -0.42 -6.19 -0.32 1.78e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs1348850 0.632 rs1405718 chr2:178499809 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.98 0.31 5.83e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg16482183 chr6:26056742 HIST1H1C 0.55 8.16 0.41 6.88e-15 Height; LUSC cis rs78579285 0.584 rs35265318 chr16:88800785 C/T cg01900006 chr16:88814613 FAM38A 0.61 6.83 0.35 4.14e-11 Joint mobility (Beighton score); LUSC cis rs4654899 0.931 rs10753506 chr1:21141022 A/G cg01072550 chr1:21505969 NA 0.48 7.2 0.37 4.09e-12 Superior frontal gyrus grey matter volume; LUSC trans rs7824557 0.527 rs2572449 chr8:11239137 A/G cg08975724 chr8:8085496 FLJ10661 0.42 6.49 0.33 3.03e-10 Retinal vascular caliber; LUSC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg18876405 chr7:65276391 NA -0.72 -12.84 -0.57 6e-31 Aortic root size; LUSC cis rs1372520 0.748 rs2737002 chr4:90753180 A/G cg01966878 chr4:90757139 SNCA -0.46 -6.66 -0.34 1.15e-10 Neuroticism; LUSC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg07936489 chr17:37558343 FBXL20 -0.68 -9.0 -0.44 1.8e-17 Glomerular filtration rate (creatinine); LUSC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg00509249 chr6:109615579 CCDC162 0.33 5.94 0.31 7.06e-9 Reticulocyte fraction of red cells; LUSC cis rs9300255 0.770 rs12299125 chr12:123862447 C/T cg13010344 chr12:123464640 ARL6IP4 0.51 6.57 0.34 1.96e-10 Neutrophil percentage of white cells; LUSC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.24 0.45 2.94e-18 Total body bone mineral density; LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.18 0.61 4.59e-36 Platelet count; LUSC cis rs9325144 0.505 rs10785560 chr12:38636622 C/T cg26384229 chr12:38710491 ALG10B 0.8 13.2 0.59 2.74e-32 Morning vs. evening chronotype; LUSC cis rs8077577 0.945 rs8069094 chr17:18096528 C/T cg16794390 chr17:18148240 FLII 0.4 5.76 0.3 1.9e-8 Obesity-related traits; LUSC cis rs6750047 0.625 rs336037 chr2:38261124 T/C cg07380506 chr2:38303506 CYP1B1 -0.44 -6.09 -0.32 3.09e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs10089 1.000 rs72794401 chr5:127517626 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.02 0.52 2.63e-24 Ileal carcinoids; LUSC cis rs4242434 0.672 rs900266 chr8:22485295 A/T cg03733263 chr8:22462867 KIAA1967 0.77 12.49 0.56 1.25e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg08999081 chr20:33150536 PIGU -0.39 -7.15 -0.36 5.45e-12 Height; LUSC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg12560992 chr17:57184187 TRIM37 -0.9 -17.62 -0.69 1.35e-49 Intelligence (multi-trait analysis); LUSC cis rs1953600 0.645 rs7071579 chr10:81910278 A/G cg00277334 chr10:82204260 NA 0.42 6.42 0.33 4.72e-10 Sarcoidosis; LUSC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg00149659 chr3:10157352 C3orf10 0.62 8.57 0.42 3.84e-16 Alzheimer's disease; LUSC cis rs36051895 0.623 rs7027871 chr9:5236822 C/G cg02405213 chr9:5042618 JAK2 0.48 6.57 0.34 1.97e-10 Pediatric autoimmune diseases; LUSC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg09177884 chr7:1199841 ZFAND2A -0.44 -6.04 -0.31 4.12e-9 Longevity;Endometriosis; LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg23758822 chr17:41437982 NA 1.04 20.08 0.74 2.21e-59 Menopause (age at onset); LUSC cis rs3812831 0.695 rs6560936 chr13:114945972 C/T cg08824895 chr13:115047677 UPF3A -0.55 -8.56 -0.42 4.09e-16 Schizophrenia; LUSC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.92 13.28 0.59 1.37e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6496044 0.634 rs4843066 chr15:86062911 C/T cg13263323 chr15:86062960 AKAP13 -0.39 -6.38 -0.33 5.88e-10 Interstitial lung disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg18882576 chr2:191184621 HIBCH 0.41 6.75 0.35 6.66e-11 Triglycerides; LUSC cis rs6736093 0.733 rs34974772 chr2:112810011 T/C cg12686935 chr2:112915763 FBLN7 -0.4 -6.35 -0.33 7.04e-10 Coronary artery disease; LUSC cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC trans rs5756813 0.727 rs58765732 chr22:38160794 A/C cg19894588 chr14:64061835 NA -0.56 -7.42 -0.38 9.85e-13 Optic cup area;Vertical cup-disc ratio; LUSC cis rs12594515 1.000 rs6493175 chr15:45989898 T/C cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC cis rs12476592 0.602 rs6546018 chr2:63817422 G/T cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs3806843 0.966 rs11741994 chr5:140145949 G/A cg26395211 chr5:140044315 WDR55 -0.4 -6.15 -0.32 2.25e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg01475377 chr6:109611718 NA -0.37 -6.46 -0.33 3.61e-10 Reticulocyte fraction of red cells; LUSC cis rs9612 1.000 rs346528 chr19:44259232 G/T cg08581076 chr19:44259116 C19orf61 0.53 6.66 0.34 1.1e-10 Exhaled nitric oxide output; LUSC cis rs3768617 0.510 rs729819 chr1:183109034 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.64 0.5 5.6e-23 Fuchs's corneal dystrophy; LUSC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.8 -0.35 4.95e-11 Breast cancer; LUSC cis rs425277 1.000 rs262654 chr1:2089526 G/A cg24578937 chr1:2090814 PRKCZ 0.6 13.94 0.61 3.84e-35 Height; LUSC cis rs6681460 0.966 rs7542924 chr1:67143055 C/T cg02459107 chr1:67143332 SGIP1 0.49 9.3 0.45 1.87e-18 Presence of antiphospholipid antibodies; LUSC cis rs2404602 0.692 rs35138393 chr15:76977617 G/A cg26408565 chr15:76604113 ETFA -0.49 -7.72 -0.39 1.38e-13 Blood metabolite levels; LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg06387496 chr7:2775674 GNA12 -0.36 -5.84 -0.3 1.21e-8 Height; LUSC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg24531977 chr5:56204891 C5orf35 -0.58 -8.63 -0.43 2.62e-16 Breast cancer;Breast cancer (early onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24357026 chr19:36705589 ZNF565;ZNF146 0.47 6.8 0.35 4.81e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7267979 0.934 rs6037085 chr20:25305202 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.57 -0.75 2.54e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9747201 1.000 rs4597372 chr17:80175444 G/A cg18209359 chr17:80159595 CCDC57 -0.36 -5.82 -0.3 1.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg08807101 chr21:30365312 RNF160 0.79 14.92 0.63 6.05e-39 Dental caries; LUSC cis rs12318506 1.000 rs35383953 chr12:75660182 A/G cg04728562 chr12:75699417 CAPS2 -0.75 -5.73 -0.3 2.28e-8 Coronary artery calcification; LUSC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg26441486 chr22:50317300 CRELD2 0.46 6.95 0.36 1.93e-11 Schizophrenia; LUSC cis rs11098499 0.644 rs3806808 chr4:120551085 A/C cg24375607 chr4:120327624 NA 0.71 11.47 0.53 6.7e-26 Corneal astigmatism; LUSC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 14.86 0.63 1.07e-38 Platelet count; LUSC cis rs6840360 0.571 rs17275577 chr4:152519899 G/A cg22705602 chr4:152727874 NA -0.32 -6.39 -0.33 5.71e-10 Intelligence (multi-trait analysis); LUSC cis rs9811920 0.625 rs9868170 chr3:99914139 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.33 6.24 0.32 1.31e-9 Axial length; LUSC cis rs2346177 0.519 rs4563285 chr2:46669944 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.57 -8.94 -0.44 2.62e-17 HDL cholesterol; LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg22166914 chr1:53195759 ZYG11B -0.61 -10.3 -0.49 8.6e-22 Monocyte count; LUSC cis rs7208859 0.623 rs12006 chr17:29110652 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9560113 1.000 rs11620313 chr13:112179363 G/A cg14154082 chr13:112174009 NA 0.37 7.63 0.39 2.53e-13 Menarche (age at onset); LUSC cis rs6977660 0.619 rs10271639 chr7:19779604 G/A cg05791153 chr7:19748676 TWISTNB 0.63 6.77 0.35 5.64e-11 Thyroid stimulating hormone; LUSC cis rs4654899 1.000 rs10799685 chr1:21465930 A/C cg02927042 chr1:21476669 EIF4G3 0.35 5.67 0.3 3.11e-8 Superior frontal gyrus grey matter volume; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg25072359 chr17:41440525 NA 0.67 9.53 0.46 3.28e-19 Menopause (age at onset); LUSC cis rs16867335 1.000 rs6739798 chr2:181465853 T/C cg23363182 chr2:181467187 NA -0.46 -5.87 -0.31 1.05e-8 Survival in rectal cancer; LUSC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg09323728 chr8:95962352 TP53INP1 -0.39 -7.59 -0.38 3.32e-13 Type 2 diabetes; LUSC cis rs4499344 0.633 rs259282 chr19:33163043 C/T cg22980127 chr19:33182716 NUDT19 -0.45 -6.7 -0.34 8.81e-11 Mean platelet volume; LUSC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg25566285 chr7:158114605 PTPRN2 0.31 5.85 0.3 1.2e-8 Calcium levels; LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg06815965 chr1:205818668 PM20D1 0.39 5.99 0.31 5.5e-9 Menarche (age at onset); LUSC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg06640241 chr16:89574553 SPG7 0.9 16.97 0.68 5.16e-47 Multiple myeloma (IgH translocation); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg12939436 chr13:29233288 POMP 0.38 6.11 0.32 2.71e-9 Asthma; LUSC trans rs7709909 0.967 rs7712332 chr5:79957835 C/T cg05588111 chr10:112678594 NCRNA00081;SHOC2 -0.45 -6.01 -0.31 4.97e-9 HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; LUSC trans rs8072100 0.967 rs11656855 chr17:45714655 C/T cg03886242 chr7:26192032 NFE2L3 0.38 6.28 0.32 1.04e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.52 0.5 1.5e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs11608355 0.545 rs6606724 chr12:109905179 T/C cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg11843238 chr5:131593191 PDLIM4 0.38 6.63 0.34 1.36e-10 Breast cancer; LUSC cis rs2762353 0.935 rs1165196 chr6:25813150 A/G cg03517284 chr6:25882590 NA 0.45 8.04 0.4 1.56e-14 Blood metabolite levels; LUSC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg03161606 chr19:29218774 NA 0.54 6.66 0.34 1.13e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg02951883 chr7:2050386 MAD1L1 -0.46 -8.0 -0.4 2.06e-14 Bipolar disorder and schizophrenia; LUSC cis rs6845621 0.901 rs7694311 chr4:18924948 G/C cg12196642 chr4:18937545 NA -0.35 -6.6 -0.34 1.66e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs868036 1.000 rs868036 chr15:68055013 T/A cg08079166 chr15:68083412 MAP2K5 -0.42 -8.6 -0.43 3.1e-16 Restless legs syndrome; LUSC cis rs2635047 1.000 rs9304341 chr18:44670263 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 7.27 0.37 2.55e-12 Educational attainment; LUSC cis rs8078723 0.763 rs4433838 chr17:38143532 C/T cg17467752 chr17:38218738 THRA -0.71 -11.39 -0.53 1.31e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg16434002 chr17:42200994 HDAC5 -0.42 -5.67 -0.3 3.04e-8 Total body bone mineral density; LUSC cis rs738321 0.757 rs12329956 chr22:38535946 G/A cg25457927 chr22:38595422 NA -0.33 -6.22 -0.32 1.48e-9 Breast cancer; LUSC trans rs11039798 0.920 rs116109043 chr11:48976940 C/T cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg22431228 chr1:16359049 CLCNKA 0.44 8.76 0.43 1.03e-16 Dilated cardiomyopathy; LUSC cis rs10492096 1.000 rs10849462 chr12:6575992 C/T cg13857086 chr12:6580257 VAMP1 0.83 9.32 0.45 1.66e-18 Hip geometry; LUSC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg25072359 chr17:41440525 NA -0.68 -9.74 -0.47 6.96e-20 Menopause (age at onset); LUSC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg20818283 chr2:191399100 TMEM194B -0.43 -6.55 -0.34 2.21e-10 Pulse pressure; LUSC cis rs1775715 0.707 rs2808073 chr10:32179275 A/G cg26784012 chr10:32216390 ARHGAP12 0.46 7.85 0.39 5.77e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs929354 0.772 rs1182365 chr7:157017255 A/T cg17757837 chr7:157058334 UBE3C -0.82 -13.3 -0.59 1.14e-32 Body mass index; LUSC cis rs3106136 0.967 rs2129595 chr4:95224454 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.25 -0.32 1.29e-9 Capecitabine sensitivity; LUSC trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs721399 0.719 rs4646254 chr8:18262059 A/G cg18736775 chr8:18248649 NAT2 -0.59 -7.43 -0.38 9.05e-13 Blood metabolite levels; LUSC cis rs11098499 0.866 rs72676074 chr4:120359841 A/C cg24375607 chr4:120327624 NA 0.77 11.37 0.53 1.59e-25 Corneal astigmatism; LUSC cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg17420585 chr12:42539391 GXYLT1 -0.38 -7.16 -0.36 5.33e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs1994135 0.617 rs2200155 chr12:33734935 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.32 0.41 2.28e-15 Resting heart rate; LUSC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg02569458 chr12:86230093 RASSF9 0.48 7.63 0.39 2.55e-13 Major depressive disorder; LUSC trans rs11098499 0.863 rs3822192 chr4:120445720 A/C cg25214090 chr10:38739885 LOC399744 0.53 7.63 0.39 2.55e-13 Corneal astigmatism; LUSC cis rs7267979 0.668 rs2387977 chr20:25599776 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.67 -12.44 -0.56 1.81e-29 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11608355 1.000 rs10774690 chr12:109859682 G/A cg05360138 chr12:110035743 NA 0.47 6.38 0.33 6.03e-10 Neuroticism; LUSC cis rs3003334 1 rs3003334 chr1:24199869 G/A cg15997130 chr1:24165203 NA 0.52 8.54 0.42 4.67e-16 Eosinophil percentage of white cells;Eosinophil percentage of granulocytes; LUSC cis rs10782582 0.592 rs7513194 chr1:76382664 A/C cg03433033 chr1:76189801 ACADM 0.39 5.65 0.3 3.5e-8 Daytime sleep phenotypes; LUSC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg19196401 chr6:110721138 DDO 0.45 8.46 0.42 8.65e-16 Platelet distribution width; LUSC cis rs11610422 1.000 rs12824459 chr12:31414435 C/T cg14306366 chr12:31406441 NA -0.51 -6.25 -0.32 1.25e-9 Coronary artery disease; LUSC cis rs4664304 0.966 rs7601374 chr2:160754050 T/C cg23995753 chr2:160760732 LY75 -0.31 -5.75 -0.3 2.05e-8 Crohn's disease;Inflammatory bowel disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24631450 chr2:234262952 DGKD 0.41 6.47 0.33 3.56e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7605827 0.897 rs1919292 chr2:15567236 A/G cg19274914 chr2:15703543 NA 0.46 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs4077468 1.000 rs11801695 chr1:205916175 A/C cg07167872 chr1:205819463 PM20D1 0.44 6.66 0.34 1.16e-10 Cystic fibrosis-related diabetes; LUSC trans rs11992162 0.550 rs61426048 chr8:11784956 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.09 -0.32 3.17e-9 Monocyte count; LUSC cis rs13082711 0.911 rs35262121 chr3:27508277 G/A cg02860705 chr3:27208620 NA 0.48 8.05 0.4 1.48e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg00908189 chr16:619842 PIGQ 0.67 10.44 0.5 2.97e-22 Height; LUSC cis rs6714788 0.565 rs9308833 chr2:100662618 C/T cg22139774 chr2:100720529 AFF3 -0.38 -6.23 -0.32 1.43e-9 Intelligence (multi-trait analysis); LUSC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg11764359 chr7:65958608 NA 0.52 6.97 0.36 1.71e-11 Aortic root size; LUSC trans rs10506458 1.000 rs73128794 chr12:63445313 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -15.62 -0.65 1.1e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs4073416 0.542 rs6573614 chr14:65958703 G/A cg03016385 chr14:66212404 NA -0.38 -5.78 -0.3 1.73e-8 N-glycan levels; LUSC cis rs4474465 0.915 rs7128449 chr11:78206760 G/A cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg14440974 chr22:39074834 NA -0.39 -6.35 -0.33 7.01e-10 Menopause (age at onset); LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg01616529 chr11:638424 DRD4 -0.35 -6.02 -0.31 4.64e-9 Systemic lupus erythematosus; LUSC trans rs7567288 0.636 rs6726463 chr2:134465009 G/T cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC cis rs9527 0.545 rs7095304 chr10:104954795 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.69 0.47 1.01e-19 Arsenic metabolism; LUSC trans rs208520 0.690 rs12208977 chr6:66725257 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.7 0.67 6.27e-46 Exhaled nitric oxide output; LUSC cis rs3741151 0.686 rs2298469 chr11:73133030 T/C cg17517138 chr11:73019481 ARHGEF17 0.8 7.35 0.37 1.56e-12 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -8.3 -0.41 2.62e-15 Personality dimensions; LUSC cis rs4820539 1.000 rs1051875 chr22:23466031 G/A cg21100191 chr22:23484243 RTDR1 0.89 15.1 0.64 1.25e-39 Bone mineral density; LUSC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg12927641 chr6:109611667 NA -0.37 -6.38 -0.33 5.82e-10 Reticulocyte fraction of red cells; LUSC cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg13535736 chr9:111863775 C9orf5 -0.39 -6.4 -0.33 5.2e-10 Menarche (age at onset); LUSC cis rs6920965 0.583 rs9388456 chr6:126147197 C/T cg05901451 chr6:126070800 HEY2 -0.55 -8.12 -0.41 9.07e-15 High light scatter reticulocyte count; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg04159381 chr1:53018615 ZCCHC11 0.45 6.36 0.33 6.61e-10 Mosquito bite size; LUSC cis rs11676348 1.000 rs11676348 chr2:219010146 C/T cg00012203 chr2:219082015 ARPC2 -0.5 -7.74 -0.39 1.18e-13 Ulcerative colitis; LUSC cis rs1981331 0.867 rs76188425 chr21:48002207 C/T cg23283320 chr21:48055893 PRMT2 1.12 8.14 0.41 7.72e-15 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.85 -0.35 3.46e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9906944 0.933 rs35051752 chr17:47089908 G/A cg14634687 chr17:47094252 IGF2BP1 0.33 7.13 0.36 6.33e-12 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.43 0.53 8.95e-26 Prudent dietary pattern; LUSC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.79 0.35 5.21e-11 Tonsillectomy; LUSC cis rs4561483 0.667 rs3743590 chr16:11930337 A/C cg08843971 chr16:11963173 GSPT1 -0.42 -6.17 -0.32 1.98e-9 Testicular germ cell tumor; LUSC cis rs921968 0.541 rs578450 chr2:219401237 C/T cg02176678 chr2:219576539 TTLL4 0.74 14.55 0.62 1.7e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs68170813 0.559 rs4730226 chr7:106887274 A/C cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs75920871 0.528 rs1531706 chr11:116943952 C/A cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.48 -0.33 3.25e-10 Subjective well-being; LUSC cis rs9318086 0.712 rs1886970 chr13:24440498 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.42 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg22029157 chr1:209979665 IRF6 0.74 10.99 0.52 3.49e-24 Cleft lip with or without cleft palate; LUSC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg05425664 chr17:57184151 TRIM37 0.54 7.98 0.4 2.31e-14 Intelligence (multi-trait analysis); LUSC trans rs2204008 0.542 rs34770471 chr12:38009613 C/T cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.53e-9 Bladder cancer; LUSC cis rs11039100 1.000 rs1470873 chr11:5827395 A/C cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.57 -0.5 1.04e-22 Alzheimer's disease; LUSC cis rs28830936 1.000 rs2004162 chr15:41965542 A/G cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.1 -0.32 2.87e-9 Diastolic blood pressure; LUSC cis rs4243830 0.850 rs4908915 chr1:6601607 T/C cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.03 -0.31 4.3e-9 Body mass index; LUSC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg26924012 chr15:45694286 SPATA5L1 1.12 19.83 0.74 2.12e-58 Homoarginine levels; LUSC cis rs1979679 0.573 rs2348417 chr12:28735596 G/A cg13890972 chr12:28721907 NA -0.42 -5.93 -0.31 7.61e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg11843238 chr5:131593191 PDLIM4 0.34 5.93 0.31 7.38e-9 Breast cancer; LUSC cis rs12220238 1.000 rs11000941 chr10:76018301 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.79 0.35 5.22e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs929354 0.772 rs6967764 chr7:156994964 C/T cg05182265 chr7:156933206 UBE3C -0.6 -9.63 -0.47 1.63e-19 Body mass index; LUSC cis rs11785400 0.793 rs9297969 chr8:143723237 A/G cg10596483 chr8:143751796 JRK 0.52 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.6 8.25 0.41 3.6e-15 Body mass index (adult); LUSC cis rs4363385 0.818 rs12085426 chr1:153003074 C/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.71 -0.39 1.49e-13 Inflammatory skin disease; LUSC cis rs3008870 0.755 rs2815355 chr1:67485034 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.33 0.56 4.92e-29 Lymphocyte percentage of white cells; LUSC cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.12 0.45 7.45e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7709377 0.595 rs41271 chr5:115629354 T/C cg23108291 chr5:115420582 COMMD10 -0.42 -6.03 -0.31 4.29e-9 Metabolite levels (X-11787); LUSC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 7.24 0.37 3.12e-12 Hip circumference adjusted for BMI; LUSC trans rs75804782 0.690 rs56198112 chr2:239348887 A/G cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.11e-10 Morning vs. evening chronotype;Chronotype; LUSC trans rs2254546 0.516 rs35451117 chr8:11398335 C/A cg22980483 chr2:80023725 CTNNA2 0.37 6.02 0.31 4.61e-9 Systemic lupus erythematosus;Kawasaki disease; LUSC trans rs979233 0.502 rs276252 chr5:42062822 G/A cg07010552 chr17:7358735 CHRNB1 -0.42 -6.02 -0.31 4.47e-9 Systemic lupus erythematosus; LUSC cis rs9308433 0.553 rs11120299 chr1:214509407 C/A cg06198575 chr1:214491504 SMYD2 0.44 6.91 0.35 2.44e-11 IgG glycosylation; LUSC cis rs11098499 0.863 rs6858777 chr4:120475966 A/G cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg09877947 chr5:131593287 PDLIM4 0.48 7.95 0.4 2.96e-14 Breast cancer; LUSC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.74 -0.39 1.21e-13 Chronic sinus infection; LUSC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg08213375 chr14:104286397 PPP1R13B 0.4 7.07 0.36 9.18e-12 Reticulocyte count; LUSC cis rs12295403 1.000 rs12789252 chr11:18690389 C/T cg09887367 chr11:18690185 NA -0.37 -7.75 -0.39 1.12e-13 Ovarian reserve; LUSC trans rs6981523 0.553 rs11783890 chr8:11056388 T/C cg15556689 chr8:8085844 FLJ10661 -0.48 -6.28 -0.32 1.04e-9 Neuroticism; LUSC cis rs644799 0.542 rs10831416 chr11:95467220 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.52 7.04 0.36 1.09e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg23758822 chr17:41437982 NA 1.04 19.44 0.73 7.67e-57 Menopause (age at onset); LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg16393715 chr7:1948819 MAD1L1 0.4 6.8 0.35 4.9e-11 Bipolar disorder and schizophrenia; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg14765337 chr11:45931715 PEX16 -0.4 -6.71 -0.34 8.35e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg12257692 chr3:49977190 RBM6 0.26 7.26 0.37 2.74e-12 Intelligence (multi-trait analysis); LUSC cis rs981844 0.645 rs72731677 chr4:154671475 C/G cg14289246 chr4:154710475 SFRP2 0.51 6.57 0.34 1.98e-10 Response to statins (LDL cholesterol change); LUSC cis rs11997175 0.713 rs4327826 chr8:33654807 T/G ch.8.33884649F chr8:33765107 NA 0.48 7.72 0.39 1.38e-13 Body mass index; LUSC cis rs1113500 0.933 rs4593854 chr1:108638519 A/G cg06207961 chr1:108661230 NA 0.39 7.16 0.36 5.22e-12 Growth-regulated protein alpha levels; LUSC cis rs9329221 0.772 rs7824675 chr8:10243418 G/T cg27411982 chr8:10470053 RP1L1 -0.49 -8.28 -0.41 2.9e-15 Neuroticism; LUSC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -10.95 -0.51 4.9e-24 Systemic lupus erythematosus; LUSC cis rs8014204 0.720 rs34752362 chr14:75232306 G/A cg06637938 chr14:75390232 RPS6KL1 0.61 9.88 0.48 2.32e-20 Caffeine consumption; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 10.05 0.48 6.22e-21 Lymphocyte counts; LUSC cis rs1997103 1.000 rs10263552 chr7:55404747 C/T cg17469321 chr7:55412551 NA 0.66 10.62 0.5 6.87e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg24733560 chr20:60626293 TAF4 0.35 5.74 0.3 2.17e-8 Body mass index; LUSC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.37 -5.72 -0.3 2.42e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9527 0.615 rs11191485 chr10:104729816 G/C cg23093090 chr10:104574429 C10orf26 -0.36 -6.66 -0.34 1.12e-10 Arsenic metabolism; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.72 -10.94 -0.51 5.17e-24 Lymphocyte counts; LUSC cis rs10089 1.000 rs4835943 chr5:127457569 A/G cg19767477 chr5:127420684 SLC12A2 -0.43 -5.7 -0.3 2.58e-8 Ileal carcinoids; LUSC trans rs2262909 0.962 rs55728714 chr19:22262899 A/G cg05197062 chr11:11642011 GALNTL4 0.57 7.92 0.4 3.5e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7106204 0.748 rs6484024 chr11:24210079 T/C ch.11.24196551F chr11:24239977 NA 1.13 12.74 0.57 1.39e-30 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg10172584 chr19:19639581 YJEFN3 0.47 5.72 0.3 2.42e-8 Bipolar disorder; LUSC trans rs1268789 0.545 rs4975067 chr4:79369767 C/A cg06112894 chr8:141469983 TRAPPC9 0.22 5.96 0.31 6.33e-9 Hair shape;Hair morphology; LUSC cis rs6964587 1.000 rs7802788 chr7:91736874 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.88 0.31 1.02e-8 Breast cancer; LUSC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -14.06 -0.61 1.38e-35 Extrinsic epigenetic age acceleration; LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg07507251 chr3:52567010 NT5DC2 0.3 5.93 0.31 7.47e-9 Cognitive function; LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg07167872 chr1:205819463 PM20D1 -0.46 -6.66 -0.34 1.11e-10 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs79349575 0.783 rs58591767 chr17:47026076 G/A cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC cis rs1808579 0.935 rs57440424 chr18:21108614 G/A cg14672496 chr18:21087552 C18orf8 0.36 6.23 0.32 1.43e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC trans rs12692738 0.526 rs355874 chr2:165632668 G/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4363385 0.588 rs1577960 chr1:153025687 G/A cg00922841 chr1:152955080 SPRR1A -0.38 -6.53 -0.34 2.42e-10 Inflammatory skin disease; LUSC cis rs9296092 0.538 rs62405941 chr6:33517297 G/A cg13560919 chr6:33536144 NA -0.84 -15.62 -0.65 1.08e-41 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg05855489 chr10:104503620 C10orf26 0.58 9.29 0.45 2e-18 Reticulocyte count; LUSC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg03433033 chr1:76189801 ACADM -0.72 -9.62 -0.47 1.67e-19 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00260888 chr20:30865478 KIF3B -0.39 -6.07 -0.32 3.38e-9 Hepatitis; LUSC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg03806693 chr22:41940476 POLR3H 0.99 14.32 0.62 1.31e-36 Vitiligo; LUSC cis rs6088580 0.524 rs7269596 chr20:33229063 T/C cg07148914 chr20:33460835 GGT7 -0.52 -8.12 -0.41 8.94e-15 Glomerular filtration rate (creatinine); LUSC cis rs714027 0.605 rs1989870 chr22:30472254 A/G cg11564601 chr22:30592435 NA 0.33 5.78 0.3 1.73e-8 Lymphocyte counts; LUSC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg21475434 chr5:93447410 FAM172A -0.86 -9.45 -0.46 6.2800000000000005e-19 Diabetic retinopathy; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.11 -0.48 3.97e-21 Obesity-related traits; LUSC cis rs72772090 0.539 rs56213813 chr5:96112284 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -7.27 -0.37 2.59e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.19 0.52 6.63e-25 Menopause (age at onset); LUSC cis rs13401104 0.796 rs72620810 chr2:237117697 A/G cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg24692254 chr21:30365293 RNF160 0.75 11.86 0.54 2.66e-27 Pancreatic cancer; LUSC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg00074818 chr8:8560427 CLDN23 0.57 9.66 0.47 1.29e-19 Obesity-related traits; LUSC cis rs8060686 0.516 rs12599238 chr16:68276235 G/A cg09835421 chr16:68378352 PRMT7 -0.67 -7.05 -0.36 1.03e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg17063962 chr7:91808500 NA 0.58 9.28 0.45 2.15e-18 Breast cancer; LUSC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg07424592 chr7:64974309 NA 0.68 6.05 0.31 3.8e-9 Diabetic kidney disease; LUSC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg03213289 chr20:61660250 NA 0.67 13.65 0.6 5.25e-34 Prostate cancer (SNP x SNP interaction); LUSC cis rs2834081 0.536 rs11702285 chr21:34474294 G/A cg00274965 chr21:34405681 NA 0.4 6.72 0.34 8.01e-11 Sum eosinophil basophil counts; LUSC cis rs11122272 0.735 rs973253 chr1:231520874 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg21681030 chr2:46777652 RHOQ 0.52 7.45 0.38 8.06e-13 Height; LUSC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg08219700 chr8:58056026 NA 0.65 7.21 0.37 3.67e-12 Developmental language disorder (linguistic errors); LUSC cis rs1953600 0.870 rs12770550 chr10:81953451 G/T cg00277334 chr10:82204260 NA 0.45 7.03 0.36 1.2e-11 Sarcoidosis; LUSC cis rs4478858 0.735 rs11576621 chr1:31795460 A/G cg00250761 chr1:31883323 NA -0.35 -8.75 -0.43 1.09e-16 Alcohol dependence; LUSC cis rs11112613 0.713 rs73184082 chr12:105951748 T/C cg03607813 chr12:105948248 NA 0.78 11.89 0.55 1.96e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.86 -0.31 1.13e-8 Alzheimer's disease (late onset); LUSC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg13683864 chr3:40499215 RPL14 -1.05 -18.85 -0.72 1.63e-54 Renal cell carcinoma; LUSC cis rs10193935 0.901 rs6544529 chr2:42510652 A/T cg27598129 chr2:42591480 NA -0.64 -8.71 -0.43 1.39e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg18240062 chr17:79603768 NPLOC4 -0.69 -12.86 -0.58 4.98e-31 Eye color traits; LUSC cis rs6542838 0.611 rs1976766 chr2:99522754 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.93 -0.35 2.15e-11 Fear of minor pain; LUSC cis rs7511006 1.000 rs17836662 chr22:50672154 A/G cg07895657 chr22:50616420 PANX2 0.34 5.96 0.31 6.26e-9 Obesity-related traits; LUSC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg06618935 chr21:46677482 NA -0.39 -7.74 -0.39 1.16e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2070488 0.775 rs6599204 chr3:38525734 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 11.88 0.55 2.16e-27 Electrocardiographic conduction measures; LUSC trans rs61931739 0.500 rs7977194 chr12:34408459 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.68 0.65 6.55e-42 Morning vs. evening chronotype; LUSC trans rs7937682 1.000 rs11213980 chr11:111562692 A/T cg18187862 chr3:45730750 SACM1L -0.58 -7.47 -0.38 7.1e-13 Primary sclerosing cholangitis; LUSC cis rs9649213 0.614 rs2240348 chr7:97984077 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.7 -9.91 -0.48 1.9e-20 Prostate cancer (SNP x SNP interaction); LUSC cis rs9788682 1.000 rs35212593 chr15:78831826 G/A cg24631222 chr15:78858424 CHRNA5 0.84 11.42 0.53 1.05e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg22029157 chr1:209979665 IRF6 0.52 8.37 0.42 1.6e-15 Monobrow; LUSC cis rs9814567 0.752 rs13098546 chr3:134333161 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.78 12.65 0.57 3.08e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7829975 0.846 rs1879957 chr8:8544808 T/C cg14343924 chr8:8086146 FLJ10661 -0.4 -5.71 -0.3 2.52e-8 Mood instability; LUSC cis rs61776719 0.738 rs7555461 chr1:38444749 T/C cg17077180 chr1:38461687 NA -0.54 -9.43 -0.46 6.96e-19 Coronary artery disease; LUSC cis rs1256061 0.603 rs1256036 chr14:64743332 C/T cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.18e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7582180 0.614 rs4851309 chr2:100975390 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.7 -0.43 1.53e-16 Intelligence (multi-trait analysis); LUSC cis rs9747201 0.963 rs11077982 chr17:80147377 G/C cg18209359 chr17:80159595 CCDC57 -0.39 -6.66 -0.34 1.15e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7615952 0.546 rs2979340 chr3:125341384 C/T cg05084668 chr3:125655381 ALG1L -0.45 -6.02 -0.31 4.67e-9 Blood pressure (smoking interaction); LUSC cis rs4253772 0.530 rs79354880 chr22:46746419 C/A cg09491104 chr22:46646882 C22orf40 -0.74 -6.78 -0.35 5.44e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs7705502 1.000 rs56197583 chr5:173336792 G/A cg18693985 chr5:173351052 CPEB4 -0.37 -5.98 -0.31 5.85e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs546131 1.000 rs546131 chr11:34851760 G/C cg11058730 chr11:34937778 PDHX;APIP 0.48 6.51 0.34 2.82e-10 Lung disease severity in cystic fibrosis; LUSC cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg06454157 chr6:167490870 NA -0.25 -6.07 -0.31 3.57e-9 Crohn's disease; LUSC cis rs9640161 0.750 rs3735169 chr7:150034378 A/G cg10018233 chr7:150070692 REPIN1 0.4 6.67 0.34 1.04e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs6722750 0.901 rs7567728 chr2:64411932 A/C cg22352474 chr2:64371530 PELI1 -0.53 -7.84 -0.39 6.25e-14 Neuroticism; LUSC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg09034736 chr1:150693464 HORMAD1 0.52 7.5 0.38 5.7e-13 Tonsillectomy; LUSC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg25566285 chr7:158114605 PTPRN2 -0.33 -6.06 -0.31 3.61e-9 Calcium levels; LUSC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg02269571 chr22:50332266 NA -0.48 -7.16 -0.36 5.04e-12 Schizophrenia; LUSC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg05234568 chr11:5960015 NA -0.53 -8.19 -0.41 5.78e-15 DNA methylation (variation); LUSC cis rs11112613 0.775 rs61200462 chr12:105969271 G/A cg03607813 chr12:105948248 NA 0.81 11.23 0.52 4.75e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg07741184 chr6:167504864 NA -0.38 -6.93 -0.35 2.13e-11 Crohn's disease; LUSC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg11663144 chr21:46675770 NA -0.41 -7.17 -0.37 4.73e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4746818 0.892 rs10823298 chr10:70867083 T/C cg11621586 chr10:70884670 VPS26A 1.05 11.71 0.54 9.17e-27 Left atrial antero-posterior diameter; LUSC cis rs6681460 0.649 rs1856315 chr1:67005229 A/G cg02459107 chr1:67143332 SGIP1 0.37 6.27 0.32 1.11e-9 Presence of antiphospholipid antibodies; LUSC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg21963583 chr11:68658836 MRPL21 0.56 8.55 0.42 4.63e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs909674 0.514 rs7423 chr22:39781429 C/T cg05872129 chr22:39784769 NA -0.6 -11.18 -0.52 7.36e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC trans rs7819412 0.659 rs4073948 chr8:10772644 A/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.26 -0.37 2.74e-12 Triglycerides; LUSC cis rs8078723 1.000 rs4794823 chr17:38166265 A/T cg17467752 chr17:38218738 THRA 0.77 12.45 0.56 1.7e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs7726839 0.540 rs3792720 chr5:643028 T/G cg11887960 chr12:57824829 NA 0.53 6.64 0.34 1.23e-10 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19139554 chr3:50126253 RBM5 -0.44 -6.21 -0.32 1.56e-9 Electrocardiographic conduction measures; LUSC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg18225595 chr11:63971243 STIP1 0.51 6.33 0.33 7.83e-10 Mean platelet volume; LUSC cis rs2652834 0.904 rs7175602 chr15:63367032 T/C cg05507819 chr15:63340323 TPM1 -0.72 -9.24 -0.45 2.93e-18 HDL cholesterol; LUSC cis rs3942852 0.868 rs7118226 chr11:48106267 T/G cg20307385 chr11:47447363 PSMC3 0.55 6.42 0.33 4.77e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg06484146 chr7:12443880 VWDE -0.73 -7.35 -0.37 1.58e-12 Coronary artery disease; LUSC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg22862634 chr11:62369728 EML3;MTA2 0.59 9.56 0.46 2.65e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9326248 0.520 rs1446105 chr11:116798544 C/T cg10130564 chr11:117069849 TAGLN 0.31 5.75 0.3 2.01e-8 Blood protein levels; LUSC cis rs11105298 0.891 rs11105302 chr12:89891366 A/G cg00757033 chr12:89920650 WDR51B -0.51 -8.97 -0.44 2.15e-17 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg26880961 chr2:92231224 NA -0.45 -7.4 -0.38 1.14e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6977660 0.607 rs10243965 chr7:19797893 G/A cg07541023 chr7:19748670 TWISTNB 0.65 6.89 0.35 2.82e-11 Thyroid stimulating hormone; LUSC cis rs9287719 0.967 rs6432113 chr2:10744889 C/T cg03983476 chr2:10830698 NOL10 0.37 5.7 0.3 2.7e-8 Prostate cancer; LUSC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.34 0.37 1.62e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.604 rs1018814 chr22:50036900 T/C cg05373962 chr22:49881684 NA -0.41 -8.71 -0.43 1.39e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8114671 0.836 rs2038504 chr20:33648187 T/C cg07148914 chr20:33460835 GGT7 -0.46 -6.8 -0.35 4.88e-11 Height; LUSC cis rs7568458 0.684 rs7608074 chr2:85809703 T/G cg17127132 chr2:85788382 GGCX 0.42 5.9 0.31 9.03e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10779751 0.690 rs2791646 chr1:11133242 C/T cg04508216 chr1:11107452 MASP2 0.31 5.65 0.3 3.43e-8 Body mass index; LUSC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.51 0.65 3.1e-41 Platelet count; LUSC cis rs2115630 1.000 rs11854313 chr15:85304048 G/C cg11189052 chr15:85197271 WDR73 -0.44 -6.42 -0.33 4.63e-10 P wave terminal force; LUSC cis rs17095355 1.000 rs55717725 chr10:111666629 T/C cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.27 -0.37 2.51e-12 Biliary atresia; LUSC trans rs1459104 0.866 rs34179570 chr11:54823141 C/T cg15704280 chr7:45808275 SEPT13 0.71 6.25 0.32 1.22e-9 Body mass index; LUSC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg02569458 chr12:86230093 RASSF9 0.52 8.61 0.43 2.94e-16 Major depressive disorder; LUSC cis rs2798269 0.933 rs2315545 chr13:22076491 C/T cg18095732 chr13:22033692 ZDHHC20 -0.38 -5.71 -0.3 2.49e-8 PR segment; LUSC cis rs7809950 1.000 rs3801944 chr7:107255548 T/C cg23024343 chr7:107201750 COG5 0.54 8.33 0.41 2.17e-15 Coronary artery disease; LUSC cis rs6725041 0.532 rs12623803 chr2:213201642 G/C cg16329650 chr2:213403929 ERBB4 -0.42 -6.67 -0.34 1.06e-10 QT interval (ambient particulate matter interaction); LUSC cis rs2273669 0.667 rs12200531 chr6:109320441 T/C cg05315195 chr6:109294784 ARMC2 -0.53 -5.94 -0.31 7.15e-9 Prostate cancer; LUSC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg18876405 chr7:65276391 NA 0.54 8.47 0.42 7.77e-16 Aortic root size; LUSC cis rs1401999 0.690 rs1402001 chr3:183642751 A/G cg01324343 chr3:183735012 ABCC5 0.65 16.67 0.67 8.27e-46 Anterior chamber depth; LUSC cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg16586182 chr3:47516702 SCAP -0.52 -8.11 -0.41 1e-14 Colorectal cancer; LUSC cis rs9393777 0.557 rs6933999 chr6:27074929 G/A cg12292205 chr6:26970375 C6orf41 -0.64 -9.18 -0.45 4.53e-18 Intelligence (multi-trait analysis); LUSC trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg03929089 chr4:120376271 NA 0.77 8.48 0.42 7.34e-16 Axial length; LUSC cis rs7707921 0.881 rs112355050 chr5:81386035 C/T cg15871215 chr5:81402204 ATG10 -0.44 -6.39 -0.33 5.69e-10 Breast cancer; LUSC cis rs9303542 0.694 rs4793854 chr17:46572133 A/G cg09704116 chr17:46666958 LOC404266 0.32 6.01 0.31 4.88e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs7481584 0.624 rs451060 chr11:3056389 G/A cg25174290 chr11:3078921 CARS -0.41 -6.08 -0.32 3.28e-9 Calcium levels; LUSC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg06558623 chr16:89946397 TCF25 1.11 9.73 0.47 7.07e-20 Skin colour saturation; LUSC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg12927641 chr6:109611667 NA -0.4 -6.81 -0.35 4.61e-11 Reticulocyte fraction of red cells; LUSC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg11812906 chr14:75593930 NEK9 0.65 11.16 0.52 8.82e-25 Height; LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg16606324 chr3:10149918 C3orf24 0.68 9.98 0.48 1.06e-20 Alzheimer's disease; LUSC cis rs2455601 0.608 rs10840137 chr11:8890079 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -7.51 -0.38 5.27e-13 Schizophrenia; LUSC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg11812906 chr14:75593930 NEK9 -0.64 -10.89 -0.51 7.59e-24 Height; LUSC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg04166393 chr7:2884313 GNA12 0.44 6.11 0.32 2.74e-9 Height; LUSC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg23260525 chr10:116636907 FAM160B1 0.48 10.32 0.49 7.3e-22 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6570726 1.000 rs1935615 chr6:145921117 G/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.78 -0.3 1.72e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg05776053 chr2:74358815 NA -0.43 -6.76 -0.35 6.04e-11 Gestational age at birth (maternal effect); LUSC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg25427524 chr10:38739819 LOC399744 -0.71 -13.26 -0.59 1.53e-32 Extrinsic epigenetic age acceleration; LUSC cis rs13401104 0.796 rs72620803 chr2:237110460 T/C cg19324714 chr2:237145437 ASB18 0.42 5.65 0.3 3.43e-8 Educational attainment; LUSC cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC trans rs12200782 0.872 rs41266837 chr6:26409729 G/A cg11837749 chr1:55047332 ACOT11 0.52 6.28 0.32 1.06e-9 Small cell lung carcinoma; LUSC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg09165964 chr15:75287851 SCAMP5 -1.05 -15.08 -0.64 1.5e-39 Blood trace element (Zn levels); LUSC cis rs2625529 0.824 rs4777475 chr15:72218206 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.49 -0.38 6.37e-13 Red blood cell count; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg06873352 chr17:61820015 STRADA -0.69 -12.36 -0.56 3.74e-29 Prudent dietary pattern; LUSC cis rs1577917 0.958 rs13207354 chr6:86700263 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.45 -0.42 9.25e-16 Response to antipsychotic treatment; LUSC cis rs7091068 0.536 rs7893369 chr10:95410147 A/G cg20715218 chr10:95462985 C10orf4 0.62 8.33 0.41 2.1e-15 Urinary tract infection frequency; LUSC cis rs7577851 0.627 rs112826171 chr2:69672871 A/G cg10773587 chr2:69614142 GFPT1 0.55 6.61 0.34 1.49e-10 Parkinson's disease (age of onset); LUSC cis rs2046867 0.818 rs17010204 chr3:72879099 G/A cg25664220 chr3:72788482 NA -0.67 -11.58 -0.54 2.61e-26 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs8180991 0.955 rs55921265 chr8:126503915 G/A cg24553815 chr6:147728235 NA -0.44 -6.11 -0.32 2.81e-9 C-reactive protein levels or LDL-cholesterol levels (pleiotropy); LUSC cis rs10465746 0.901 rs17534614 chr1:84383079 G/A cg10977910 chr1:84465055 TTLL7 0.42 6.08 0.32 3.29e-9 Obesity-related traits; LUSC trans rs2243480 1.000 rs34970380 chr7:65431493 C/T cg10756647 chr7:56101905 PSPH 0.86 8.39 0.42 1.36e-15 Diabetic kidney disease; LUSC cis rs28595532 0.748 rs115651241 chr4:119363509 C/T cg21605333 chr4:119757512 SEC24D 1.02 8.29 0.41 2.73e-15 Cannabis dependence symptom count; LUSC cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg24812749 chr6:127587940 RNF146 0.92 13.73 0.6 2.61e-34 Breast cancer; LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg08280861 chr8:58055591 NA 0.54 5.66 0.3 3.23e-8 Developmental language disorder (linguistic errors); LUSC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg21028142 chr17:79581711 NPLOC4 -0.32 -7.6 -0.38 2.93e-13 Eye color traits; LUSC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg09491104 chr22:46646882 C22orf40 -0.64 -7.29 -0.37 2.28e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs870825 0.655 rs2310104 chr4:185619967 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg11752832 chr7:134001865 SLC35B4 0.55 8.65 0.43 2.28e-16 Mean platelet volume; LUSC cis rs2839186 0.749 rs62226489 chr21:47710519 T/C cg05896524 chr21:47604654 C21orf56 0.4 5.84 0.3 1.24e-8 Testicular germ cell tumor; LUSC cis rs7588746 0.571 rs4673891 chr2:201156362 C/G cg23649088 chr2:200775458 C2orf69 -0.42 -6.05 -0.31 3.91e-9 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs4478858 0.735 rs6681286 chr1:31799384 G/C cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg15556689 chr8:8085844 FLJ10661 0.68 9.88 0.48 2.3e-20 Red cell distribution width; LUSC cis rs17255340 0.539 rs12214015 chr6:84107124 C/T cg08257003 chr6:84140564 ME1 0.34 8.48 0.42 7.31e-16 Platelet-derived growth factor BB levels; LUSC cis rs3845702 0.935 rs3845695 chr2:180796989 A/G cg01881094 chr2:180872142 CWC22 -0.82 -10.74 -0.51 2.66e-23 Schizophrenia; LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg05896524 chr21:47604654 C21orf56 -0.53 -8.09 -0.4 1.1e-14 Testicular germ cell tumor; LUSC cis rs7666738 0.753 rs17027308 chr4:99091088 T/A cg17366294 chr4:99064904 C4orf37 0.53 9.16 0.45 5.41e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.84 0.35 3.81e-11 Tonsillectomy; LUSC cis rs7829975 0.742 rs7832968 chr8:8652889 G/A cg06636001 chr8:8085503 FLJ10661 0.65 9.89 0.48 2.17e-20 Mood instability; LUSC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1395 1.000 rs1141313 chr2:27460968 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.38 6.2 0.32 1.7e-9 Blood metabolite levels; LUSC cis rs40363 1.000 rs37768 chr16:3514777 T/C cg00484396 chr16:3507460 NAT15 0.87 11.38 0.53 1.46e-25 Tuberculosis; LUSC cis rs72634258 0.554 rs17374292 chr1:7881234 C/T cg26816564 chr1:7831052 VAMP3 0.92 13.32 0.59 9.06e-33 Inflammatory bowel disease; LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.13 0.36 6.41e-12 Platelet count; LUSC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg26441486 chr22:50317300 CRELD2 -0.54 -8.21 -0.41 4.86e-15 Schizophrenia; LUSC cis rs6942756 0.806 rs68184415 chr7:128988862 C/T cg02491457 chr7:128862824 NA -0.51 -7.74 -0.39 1.23e-13 White matter hyperintensity burden; LUSC cis rs40363 1.000 rs37769 chr16:3514580 C/G cg05754148 chr16:3507555 NAT15 0.79 9.61 0.47 1.9e-19 Tuberculosis; LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.43 -5.72 -0.3 2.32e-8 Gut microbiome composition (summer); LUSC trans rs7618501 0.633 rs11130234 chr3:50024758 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.92 0.44 3.12e-17 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.32 -0.33 8.16e-10 Menopause (age at onset); LUSC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg24209194 chr3:40518798 ZNF619 0.44 5.82 0.3 1.36e-8 Renal cell carcinoma; LUSC cis rs2652834 0.808 rs6494393 chr15:63426435 A/C cg05507819 chr15:63340323 TPM1 0.45 5.82 0.3 1.37e-8 HDL cholesterol; LUSC trans rs11039798 0.623 rs588700 chr11:48449889 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -7.07 -0.36 9.11e-12 Axial length; LUSC cis rs9815354 0.812 rs17218103 chr3:41943724 A/G cg03022575 chr3:42003672 ULK4 0.81 8.49 0.42 6.81e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg18099408 chr3:52552593 STAB1 -0.41 -7.03 -0.36 1.2e-11 Bipolar disorder; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg09177884 chr7:1199841 ZFAND2A -0.47 -6.21 -0.32 1.56e-9 Longevity;Endometriosis; LUSC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs34779708 0.931 rs12261654 chr10:35322024 G/A cg04310649 chr10:35416472 CREM -0.4 -6.07 -0.32 3.45e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2191566 1.000 rs384544 chr19:44505255 A/T cg03039196 chr19:44506973 ZNF230 -0.37 -5.86 -0.31 1.14e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg08847533 chr14:75593920 NEK9 0.84 14.5 0.62 2.61e-37 Height; LUSC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.59 -0.38 3.19e-13 Developmental language disorder (linguistic errors); LUSC trans rs6076960 0.652 rs3852945 chr20:6254118 T/C cg24759859 chr6:86352639 SYNCRIP 0.41 5.97 0.31 6.06e-9 Smooth-surface caries; LUSC cis rs4631830 0.720 rs12412140 chr10:51503977 T/C cg16070123 chr10:51489643 NA 0.55 9.19 0.45 4.36e-18 Prostate-specific antigen levels; LUSC trans rs208520 0.802 rs208516 chr6:66946119 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.93 -0.61 4.39e-35 Exhaled nitric oxide output; LUSC cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg16386425 chr10:429943 DIP2C 0.41 5.92 0.31 8.21e-9 Psychosis in Alzheimer's disease; LUSC cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.4 0.53 1.17e-25 Colorectal cancer; LUSC cis rs11997175 0.624 rs79944133 chr8:33730588 A/G ch.8.33884649F chr8:33765107 NA 0.47 6.58 0.34 1.82e-10 Body mass index; LUSC cis rs1451375 1.000 rs2329340 chr7:50620229 C/T cg18232548 chr7:50535776 DDC 0.5 7.49 0.38 6.04e-13 Malaria; LUSC trans rs7980799 0.682 rs1601006 chr12:33629519 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.75 -0.43 1.07e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2046867 0.628 rs61159664 chr3:72916958 C/G cg25664220 chr3:72788482 NA -0.55 -9.69 -0.47 1.01e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2932538 0.922 rs999923 chr1:113110548 T/C cg22162597 chr1:113214053 CAPZA1 0.7 10.0 0.48 9.16e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7584330 0.737 rs6758246 chr2:238359891 G/C cg16989719 chr2:238392110 NA -0.35 -5.97 -0.31 6.11e-9 Prostate cancer; LUSC cis rs12908161 1.000 rs17600551 chr15:85319258 A/G cg12863693 chr15:85201151 NMB 0.41 8.42 0.42 1.11e-15 Schizophrenia; LUSC trans rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.74 -13.42 -0.59 3.98e-33 Brugada syndrome; LUSC cis rs8017423 0.967 rs4904663 chr14:90729565 G/T cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs2456568 0.548 rs10466335 chr11:93663820 G/C cg26875233 chr11:93583750 C11orf90 -0.31 -6.04 -0.31 4e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg14092988 chr3:52407081 DNAH1 0.3 5.86 0.31 1.1e-8 Bipolar disorder; LUSC cis rs7408868 1.000 rs10416389 chr19:15278674 G/C cg14696996 chr19:15285081 NOTCH3 0.97 9.33 0.45 1.56e-18 Pulse pressure; LUSC trans rs1728785 0.901 rs1170438 chr16:68608256 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.94 0.4 3.18e-14 Ulcerative colitis; LUSC cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -8.87 -0.44 4.51e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.93 -0.31 7.51e-9 Vitiligo; LUSC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -6.98 -0.36 1.55e-11 Developmental language disorder (linguistic errors); LUSC cis rs11031096 0.655 rs35898891 chr11:4211112 G/C cg18678763 chr11:4115507 RRM1 -0.41 -5.72 -0.3 2.41e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1577917 1.000 rs7760207 chr6:86721700 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.77e-10 Response to antipsychotic treatment; LUSC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg04352962 chr1:209979756 IRF6 0.53 6.2 0.32 1.68e-9 Cleft lip with or without cleft palate; LUSC cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg04850211 chr1:228464232 OBSCN 0.31 5.68 0.3 2.95e-8 Diastolic blood pressure; LUSC cis rs12893668 0.703 rs55751606 chr14:104028806 G/A cg01849466 chr14:104193079 ZFYVE21 -0.41 -5.69 -0.3 2.78e-8 Reticulocyte count; LUSC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.91 0.35 2.41e-11 Intelligence (multi-trait analysis); LUSC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg02423579 chr7:2872169 GNA12 -0.44 -6.44 -0.33 4.19e-10 Height; LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg10117171 chr1:25599238 RHD -0.37 -5.69 -0.3 2.85e-8 Erythrocyte sedimentation rate; LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg24503407 chr1:205819492 PM20D1 0.56 9.29 0.45 2.05e-18 Menarche (age at onset); LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.0 -0.31 5.25e-9 Platelet count; LUSC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg00409905 chr10:38381863 ZNF37A -0.34 -6.0 -0.31 5.18e-9 Extrinsic epigenetic age acceleration; LUSC cis rs7568458 0.846 rs6743030 chr2:85763520 C/T cg17127132 chr2:85788382 GGCX 0.45 6.98 0.36 1.55e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs5758511 0.689 rs62240864 chr22:42563889 C/T cg12850546 chr22:42539477 CYP2D7P1 -0.62 -7.0 -0.36 1.38e-11 Birth weight; LUSC cis rs8016982 0.559 rs10133562 chr14:81732758 C/T cg01989461 chr14:81687754 GTF2A1 -0.49 -6.19 -0.32 1.78e-9 Schizophrenia; LUSC cis rs12594515 1.000 rs8038058 chr15:45990272 C/T cg06207120 chr15:45996521 NA 0.39 6.03 0.31 4.28e-9 Waist circumference;Weight; LUSC cis rs6547741 0.967 rs4665986 chr2:27755168 G/A cg27432699 chr2:27873401 GPN1 0.79 14.85 0.63 1.19e-38 Oral cavity cancer; LUSC cis rs2280018 0.526 rs2966129 chr16:15152927 A/C cg07549590 chr16:15018862 NA 0.58 10.21 0.49 1.7e-21 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.34 9.51e-11 Intraocular pressure; LUSC trans rs11992162 0.551 rs13268217 chr8:11782609 T/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.37 -0.33 6.25e-10 Monocyte count; LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg14829155 chr15:31115871 NA -0.55 -7.64 -0.39 2.26e-13 Huntington's disease progression; LUSC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC trans rs2228479 0.541 rs62052173 chr16:89950739 T/C cg24644049 chr4:85504048 CDS1 0.69 7.03 0.36 1.15e-11 Skin colour saturation; LUSC cis rs3772130 0.540 rs11717089 chr3:121563271 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.83 13.54 0.6 1.29e-33 Cognitive performance; LUSC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg24399712 chr22:39784796 NA -0.63 -10.5 -0.5 1.73e-22 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs3808502 0.525 rs13280813 chr8:11425105 G/T cg08975724 chr8:8085496 FLJ10661 -0.5 -7.19 -0.37 4.31e-12 Neuroticism; LUSC cis rs7659604 0.540 rs11098643 chr4:122701507 C/A cg19748678 chr4:122722346 EXOSC9 -0.5 -7.4 -0.38 1.09e-12 Type 2 diabetes; LUSC cis rs8114671 0.967 rs2069948 chr20:33762489 C/T cg24642439 chr20:33292090 TP53INP2 0.41 5.93 0.31 7.46e-9 Height; LUSC cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.95 0.44 2.56e-17 Menopause (age at onset); LUSC cis rs11608355 0.515 rs11611012 chr12:109945203 G/A cg05360138 chr12:110035743 NA 0.93 10.92 0.51 6.12e-24 Neuroticism; LUSC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.63 -5.96 -0.31 6.45e-9 Cerebrospinal P-tau181p levels; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg24060327 chr5:131705240 SLC22A5 -0.66 -11.6 -0.54 2.26e-26 Breast cancer; LUSC cis rs9807989 0.839 rs10192157 chr2:102968356 C/T cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 5.8 0.3 1.55e-8 Electroencephalogram traits; LUSC trans rs11098499 0.697 rs4373140 chr4:120307698 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs9549260 0.755 rs3892360 chr13:41184078 C/G cg21288729 chr13:41239152 FOXO1 0.6 9.15 0.45 5.98e-18 Red blood cell count; LUSC cis rs372883 0.648 rs15092 chr21:30718201 G/A cg08807101 chr21:30365312 RNF160 -0.69 -10.67 -0.5 4.74e-23 Pancreatic cancer; LUSC cis rs12493885 0.725 rs11707232 chr3:153742077 T/A cg17054900 chr3:154042577 DHX36 -0.7 -7.37 -0.37 1.33e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9399401 0.626 rs6906468 chr6:142769386 A/G cg03128060 chr6:142623767 GPR126 0.54 9.51 0.46 3.83e-19 Chronic obstructive pulmonary disease; LUSC cis rs16958440 0.581 rs11872531 chr18:44689234 C/A cg17192377 chr18:44677553 HDHD2 0.52 6.12 0.32 2.6e-9 Sitting height ratio; LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg22638593 chr5:131593259 PDLIM4 -0.41 -5.89 -0.31 9.42e-9 Breast cancer; LUSC cis rs1044826 0.642 rs176983 chr3:139213755 G/A cg15131784 chr3:139108705 COPB2 0.4 6.4 0.33 5.34e-10 Obesity-related traits; LUSC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg02772935 chr3:125709198 NA -0.48 -5.86 -0.31 1.12e-8 Blood pressure (smoking interaction); LUSC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.0 -15.99 -0.66 3.98e-43 Platelet count; LUSC cis rs868036 0.681 rs3784718 chr15:68098004 C/T cg05925327 chr15:68127851 NA -0.4 -6.42 -0.33 4.63e-10 Restless legs syndrome; LUSC cis rs17689437 0.647 rs820799 chr16:68559537 C/A cg02508848 chr16:68573721 ZFP90 -0.38 -5.95 -0.31 6.71e-9 HIV-1 viral setpoint;Response to antipsychotic treatment in schizophrenia (reasoning); LUSC cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.13 -0.36 6.32e-12 Menopause (age at onset); LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg24813613 chr7:1882135 MAD1L1 -0.41 -6.81 -0.35 4.42e-11 Bipolar disorder and schizophrenia; LUSC cis rs3815700 1.000 rs8104328 chr19:33094371 G/A cg02997394 chr19:33096574 ANKRD27 0.79 8.95 0.44 2.44e-17 Eosinophilic esophagitis; LUSC trans rs311904 0.793 rs10775200 chr15:69331758 G/A cg07092097 chr10:88720025 SNCG -0.64 -6.15 -0.32 2.2e-9 Obesity-related traits; LUSC trans rs7939886 0.920 rs58405266 chr11:55863225 G/A cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.65e-9 Myopia (pathological); LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs861020 0.883 rs680331 chr1:209959872 G/A cg05527609 chr1:210001259 C1orf107 0.88 11.72 0.54 8.63e-27 Orofacial clefts; LUSC cis rs17540621 1.000 rs116131523 chr2:47198516 G/A cg23978866 chr2:47230407 TTC7A -0.92 -6.91 -0.35 2.44e-11 Response to statin therapy; LUSC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg06454157 chr6:167490870 NA -0.25 -6.06 -0.31 3.65e-9 Crohn's disease; LUSC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg17366294 chr4:99064904 C4orf37 -0.56 -10.04 -0.48 6.75e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.55 7.61 0.38 2.91e-13 Systemic lupus erythematosus; LUSC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg23711669 chr6:146136114 FBXO30 -0.83 -15.28 -0.64 2.38e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs4499344 0.768 rs10411319 chr19:33102805 C/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.86 13.3 0.59 1.12e-32 Mean platelet volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15222563 chr19:7745491 TRAPPC5 0.42 5.97 0.31 6.13e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg22437258 chr11:111473054 SIK2 0.48 6.51 0.34 2.69e-10 Primary sclerosing cholangitis; LUSC cis rs7582180 0.629 rs11678148 chr2:100966950 A/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.83 -0.44 5.87e-17 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.55 -0.42 4.52e-16 Lung cancer; LUSC cis rs11971779 0.941 rs28395455 chr7:139035986 A/G cg07862535 chr7:139043722 LUC7L2 0.63 7.07 0.36 9.04e-12 Diisocyanate-induced asthma; LUSC cis rs2288073 0.801 rs10175668 chr2:24367275 G/A cg20701182 chr2:24300061 SF3B14 0.52 6.74 0.35 6.86e-11 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs28595532 0.668 rs56410164 chr4:119331625 A/G cg21605333 chr4:119757512 SEC24D 1.01 8.28 0.41 3.09e-15 Cannabis dependence symptom count; LUSC cis rs2295359 1.000 rs11209007 chr1:67619345 C/G cg03340356 chr1:67600835 NA 0.39 6.45 0.33 3.81e-10 Psoriasis; LUSC cis rs6496667 0.533 rs7172909 chr15:90991416 C/T cg22089800 chr15:90895588 ZNF774 0.53 7.56 0.38 3.96e-13 Rheumatoid arthritis; LUSC cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC cis rs11677370 0.561 rs11687254 chr2:3830906 C/T cg17052675 chr2:3827356 NA -0.66 -10.87 -0.51 8.99e-24 Type 2 diabetes; LUSC cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg08807101 chr21:30365312 RNF160 -0.67 -10.34 -0.49 6.11e-22 Pancreatic cancer; LUSC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg16680214 chr1:154839983 KCNN3 -0.56 -10.94 -0.51 5.23e-24 Prostate cancer; LUSC cis rs57590327 0.503 rs13079104 chr3:81886039 A/T cg07356753 chr3:81810745 GBE1 -0.65 -10.05 -0.48 6.11e-21 Extraversion; LUSC cis rs7267979 1.000 rs401166 chr20:25446308 C/G cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg01973587 chr1:228161476 NA -0.41 -7.15 -0.36 5.48e-12 Diastolic blood pressure; LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg08280861 chr8:58055591 NA 0.57 6.79 0.35 5.08e-11 Developmental language disorder (linguistic errors); LUSC cis rs8062405 1.000 rs55991577 chr16:28843025 C/T cg09754948 chr16:28834200 ATXN2L 0.41 6.13 0.32 2.5e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9393692 0.627 rs1059486 chr6:26200083 A/G cg13736514 chr6:26305472 NA -0.36 -6.71 -0.34 8.54e-11 Educational attainment; LUSC cis rs977987 0.872 rs4887816 chr16:75319716 T/C cg04384234 chr16:75411784 CFDP1 -0.38 -6.01 -0.31 4.85e-9 Dupuytren's disease; LUSC cis rs425277 1.000 rs55826501 chr1:2059143 G/A cg03732007 chr1:2071316 PRKCZ 0.48 7.71 0.39 1.48e-13 Height; LUSC cis rs17125944 0.556 rs12588482 chr14:53311552 G/A cg00686598 chr14:53173677 PSMC6 -0.61 -5.66 -0.3 3.27e-8 Alzheimer's disease (late onset); LUSC cis rs8053891 0.614 rs34235351 chr16:71987875 G/A cg04254540 chr16:71951199 KIAA0174 -0.48 -6.65 -0.34 1.22e-10 Coronary artery disease; LUSC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg10556349 chr10:835070 NA 0.53 6.35 0.33 7.02e-10 Eosinophil percentage of granulocytes; LUSC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg05234568 chr11:5960015 NA -0.6 -8.66 -0.43 2.01e-16 DNA methylation (variation); LUSC cis rs6684514 0.885 rs12036837 chr1:156283895 A/C cg16558208 chr1:156270281 VHLL 0.39 6.03 0.31 4.43e-9 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs3806843 0.966 rs6579965 chr5:140168811 T/G cg26395211 chr5:140044315 WDR55 -0.37 -5.77 -0.3 1.78e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg18758796 chr5:131593413 PDLIM4 0.45 7.62 0.38 2.72e-13 Breast cancer; LUSC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg11584989 chr19:19387371 SF4 0.55 6.75 0.35 6.39e-11 Bipolar disorder; LUSC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg13206674 chr6:150067644 NUP43 0.6 9.53 0.46 3.38e-19 Lung cancer; LUSC cis rs7827545 0.545 rs6998092 chr8:135557449 A/G cg17885191 chr8:135476712 NA 0.62 7.9 0.4 4.19e-14 Hypertension (SNP x SNP interaction); LUSC cis rs36405 0.500 rs17178883 chr14:72355591 C/T cg23396177 chr14:72358413 NA 0.37 7.01 0.36 1.36e-11 Yang-deficiency constitution; LUSC trans rs1493916 1.000 rs9964702 chr18:31390427 A/C cg13755796 chr4:20253514 NA -0.43 -6.67 -0.34 1.07e-10 Life satisfaction; LUSC trans rs7824557 0.527 rs2409756 chr8:11242025 A/C cg06636001 chr8:8085503 FLJ10661 -0.56 -8.14 -0.41 7.97e-15 Retinal vascular caliber; LUSC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg21724239 chr8:58056113 NA 0.85 9.53 0.46 3.26e-19 Developmental language disorder (linguistic errors); LUSC trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.3 -0.45 1.93e-18 Extrinsic epigenetic age acceleration; LUSC cis rs7241530 0.662 rs55841218 chr18:75902133 G/A cg14642773 chr18:75888474 NA 0.41 6.27 0.32 1.14e-9 Educational attainment (years of education); LUSC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg11366901 chr6:160182831 ACAT2 0.95 12.87 0.58 4.49e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.76 0.39 1.01e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg20891283 chr12:69753455 YEATS4 0.68 10.76 0.51 2.27e-23 Blood protein levels; LUSC trans rs35491132 1 rs35491132 chr6:27527227 GT/G cg01620082 chr3:125678407 NA -0.72 -6.85 -0.35 3.64e-11 Urinary tract infection frequency; LUSC cis rs34311866 0.808 rs11728344 chr4:963755 T/C cg14530993 chr4:882597 GAK 0.69 6.84 0.35 3.88e-11 Parkinson's disease; LUSC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg06238570 chr21:40685208 BRWD1 0.49 7.41 0.38 1.01e-12 Cognitive function; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.06 0.58 9.27e-32 Alzheimer's disease; LUSC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg09491104 chr22:46646882 C22orf40 -0.64 -7.39 -0.37 1.22e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs12579753 0.956 rs11115039 chr12:82217338 A/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.04 -0.31 4.21e-9 Resting heart rate; LUSC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg12751644 chr20:60527061 NA 0.36 6.25 0.32 1.24e-9 Body mass index; LUSC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.44e-15 Total body bone mineral density; LUSC trans rs17685 0.712 rs56965035 chr7:75795670 G/A cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2979489 0.891 rs3824107 chr8:30353412 A/G cg26383811 chr8:30366931 RBPMS 0.51 7.45 0.38 8.02e-13 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs9467773 0.620 rs4368798 chr6:26593471 A/G cg11502198 chr6:26597334 ABT1 0.71 11.81 0.54 3.94e-27 Intelligence (multi-trait analysis); LUSC trans rs1005277 0.522 rs289648 chr10:37971837 T/C cg17830980 chr10:43048298 ZNF37B -0.39 -6.09 -0.32 3.12e-9 Extrinsic epigenetic age acceleration; LUSC cis rs12519773 0.526 rs4632783 chr5:92528309 A/G cg18783429 chr5:92414398 NA 0.33 7.03 0.36 1.18e-11 Migraine; LUSC cis rs1595825 0.891 rs2293255 chr2:198621506 T/C cg00982548 chr2:198649783 BOLL -0.58 -7.21 -0.37 3.87e-12 Ulcerative colitis; LUSC cis rs3126085 0.935 rs3126046 chr1:152256925 G/A cg26876637 chr1:152193138 HRNR -0.46 -6.38 -0.33 6.03e-10 Atopic dermatitis; LUSC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg05234568 chr11:5960015 NA -0.53 -8.23 -0.41 4.35e-15 DNA methylation (variation); LUSC cis rs4601821 0.823 rs10891546 chr11:113265292 C/T cg14159747 chr11:113255604 NA -0.25 -6.15 -0.32 2.17e-9 Alcoholic chronic pancreatitis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16003500 chr20:49547260 ADNP 0.47 6.42 0.33 4.7e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs796825 0.530 rs7612000 chr3:119965914 C/T cg21790991 chr3:120137480 FSTL1 -0.33 -5.93 -0.31 7.5e-9 HIV-1 susceptibility; LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 3.11e-13 Prudent dietary pattern; LUSC cis rs9399135 0.967 rs34546690 chr6:135369709 T/C cg24558204 chr6:135376177 HBS1L 0.57 8.81 0.43 6.87e-17 Red blood cell count; LUSC cis rs7681440 0.904 rs3756063 chr4:90757394 G/C cg01966878 chr4:90757139 SNCA -0.37 -6.38 -0.33 6.04e-10 Dementia with Lewy bodies; LUSC trans rs459571 0.959 rs2520099 chr9:136918139 T/C cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.41 -6.0 -0.31 5.25e-9 Platelet distribution width; LUSC cis rs7598759 0.548 rs11693738 chr2:232360484 C/T cg19187155 chr2:232395269 NMUR1 0.93 16.15 0.66 9.37e-44 Noise-induced hearing loss; LUSC cis rs7605827 0.675 rs2111449 chr2:15616215 C/T cg19274914 chr2:15703543 NA 0.44 7.89 0.4 4.46e-14 Educational attainment (years of education); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg17397135 chr2:28789816 PLB1 0.37 5.96 0.31 6.46e-9 Metabolite levels (Pyroglutamine); LUSC cis rs8014204 0.868 rs2230237 chr14:75359670 G/A cg06637938 chr14:75390232 RPS6KL1 -0.68 -11.44 -0.53 8.82e-26 Caffeine consumption; LUSC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg09323728 chr8:95962352 TP53INP1 0.38 7.25 0.37 2.98e-12 Type 2 diabetes; LUSC cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg16230307 chr14:35515116 FAM177A1 0.5 6.31 0.33 8.95e-10 Psoriasis; LUSC cis rs6429082 0.608 rs903348 chr1:235571343 C/T cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.82 -0.35 4.3e-11 Adiposity; LUSC cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs5771069 0.931 rs5771222 chr22:50445704 C/T cg27467552 chr22:50353597 PIM3 0.43 7.28 0.37 2.45e-12 Ulcerative colitis; LUSC cis rs7241530 0.636 rs12456531 chr18:75899668 G/C cg14642773 chr18:75888474 NA 0.38 5.69 0.3 2.75e-8 Educational attainment (years of education); LUSC cis rs738321 0.756 rs11089863 chr22:38512402 G/A cg25457927 chr22:38595422 NA -0.33 -6.16 -0.32 2.04e-9 Breast cancer; LUSC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs56283067 0.578 rs1321079 chr6:45358403 T/A cg18551225 chr6:44695536 NA -0.41 -6.33 -0.33 7.88e-10 Total body bone mineral density; LUSC cis rs1559088 0.948 rs10410778 chr19:33592301 C/A cg27124370 chr19:33622961 WDR88 0.57 7.41 0.38 1.03e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9309473 0.500 rs2421664 chr2:73858881 C/T cg20560298 chr2:73613845 ALMS1 0.43 6.51 0.34 2.82e-10 Metabolite levels; LUSC cis rs7584330 0.554 rs9646713 chr2:238443542 T/C cg16989719 chr2:238392110 NA -0.41 -5.96 -0.31 6.3e-9 Prostate cancer; LUSC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg13298116 chr11:62369859 EML3;MTA2 0.59 9.64 0.47 1.43e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg13256891 chr4:100009986 ADH5 -0.45 -6.23 -0.32 1.43e-9 Alcohol dependence; LUSC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg01570182 chr17:44337453 NA -0.67 -10.07 -0.48 5.08e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg15423357 chr2:25149977 NA 0.4 7.89 0.4 4.4e-14 Body mass index in non-asthmatics; LUSC cis rs7712401 0.601 rs35256179 chr5:122334255 C/A cg19077854 chr5:122220652 SNX24 -0.43 -9.18 -0.45 4.76e-18 Mean platelet volume; LUSC cis rs11583043 0.874 rs6577222 chr1:101420502 C/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.85 0.35 3.59e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6545883 0.562 rs777588 chr2:61426820 G/A cg15711740 chr2:61764176 XPO1 -0.4 -6.28 -0.32 1.05e-9 Tuberculosis; LUSC cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg02038168 chr22:39784481 NA -0.5 -8.2 -0.41 5.34e-15 Intelligence (multi-trait analysis); LUSC cis rs2230307 0.536 rs580678 chr1:100483009 C/A cg24955406 chr1:100503596 HIAT1 0.56 6.1 0.32 2.86e-9 Carotid intima media thickness; LUSC cis rs7666738 0.546 rs10461174 chr4:98698293 G/A cg05340658 chr4:99064831 C4orf37 0.59 8.75 0.43 1.04e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC trans rs853679 0.546 rs35819751 chr6:27810569 A/G cg09904177 chr6:26538194 HMGN4 -0.8 -6.02 -0.31 4.48e-9 Depression; LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg05064044 chr6:292385 DUSP22 -0.51 -7.6 -0.38 3.07e-13 Menopause (age at onset); LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg03188948 chr7:1209495 NA 0.68 7.2 0.37 4.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg16926213 chr1:1841314 NA 0.31 5.81 0.3 1.44e-8 Body mass index; LUSC cis rs540254 0.551 rs1961611 chr1:160773029 G/A cg20255094 chr1:160771763 LY9 0.55 6.6 0.34 1.64e-10 Blood protein levels; LUSC cis rs66887589 0.967 rs13104219 chr4:120438174 G/T cg24375607 chr4:120327624 NA 0.46 7.08 0.36 8.4e-12 Diastolic blood pressure; LUSC cis rs1577917 0.958 rs1838958 chr6:86563968 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC trans rs8073060 0.586 rs225296 chr17:33924847 C/G cg19694781 chr19:47549865 TMEM160 -1.13 -18.23 -0.71 5.2e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs561341 0.660 rs7406043 chr17:30220152 C/G cg27661571 chr11:113659931 NA -0.56 -6.33 -0.33 8.02e-10 Hip circumference adjusted for BMI; LUSC cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg24130564 chr14:104152367 KLC1 -0.48 -7.41 -0.38 1.01e-12 Intelligence (multi-trait analysis); LUSC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.74 -9.47 -0.46 5.18e-19 Chronic sinus infection; LUSC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7903847 0.642 rs11189182 chr10:99144186 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.07 -0.4 1.26e-14 Granulocyte percentage of myeloid white cells; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg26559250 chr6:158074478 ZDHHC14 0.48 6.26 0.32 1.2e-9 Neuroticism; LUSC cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg08213375 chr14:104286397 PPP1R13B 0.52 10.25 0.49 1.29e-21 Schizophrenia; LUSC trans rs10435719 0.902 rs7459983 chr8:11807221 T/C cg27411982 chr8:10470053 RP1L1 0.44 6.78 0.35 5.56e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs7681440 0.874 rs1372523 chr4:90775923 G/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.96 -0.31 6.49e-9 Dementia with Lewy bodies; LUSC cis rs9650315 0.929 rs72656021 chr8:57166381 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.07 0.36 9.07e-12 Height; LUSC cis rs9868809 0.881 rs3821876 chr3:48668394 G/T cg00383909 chr3:49044727 WDR6 1.0 8.42 0.42 1.14e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg08798685 chr6:27730294 NA -0.69 -6.14 -0.32 2.4e-9 Depression; LUSC cis rs6495122 0.630 rs12912343 chr15:75251041 C/G cg03289416 chr15:75166202 SCAMP2 0.41 5.98 0.31 5.78e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs6748734 1.000 rs4675860 chr2:241840417 A/G cg04034577 chr2:241836375 C2orf54 -0.48 -8.73 -0.43 1.27e-16 Urinary metabolites; LUSC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg02079420 chr8:82753780 SNX16 -0.37 -5.66 -0.3 3.3e-8 Diastolic blood pressure; LUSC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs7223966 1.000 rs2013288 chr17:61785904 C/T cg00945038 chr17:61921165 SMARCD2 0.39 5.94 0.31 7.26e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg08684580 chr7:98029266 BAIAP2L1 0.35 5.95 0.31 6.96e-9 Breast cancer; LUSC cis rs9443645 0.527 rs4706743 chr6:79615793 G/T cg05283184 chr6:79620031 NA -0.45 -8.5 -0.42 6.3e-16 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs2183709 chr6:135377091 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.07 0.44 1.05e-17 Red blood cell count; LUSC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg00409905 chr10:38381863 ZNF37A -0.37 -6.27 -0.32 1.1e-9 Extrinsic epigenetic age acceleration; LUSC cis rs7584330 0.910 rs880930 chr2:238396872 G/C cg16989719 chr2:238392110 NA -0.43 -7.33 -0.37 1.74e-12 Prostate cancer; LUSC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg01579765 chr21:45077557 HSF2BP -0.52 -11.0 -0.52 3.2e-24 Mean corpuscular volume; LUSC cis rs9486719 1.000 rs3798296 chr6:97052286 G/A cg06623918 chr6:96969491 KIAA0776 -0.83 -10.35 -0.49 5.66e-22 Migraine;Coronary artery disease; LUSC cis rs12711979 0.509 rs10181286 chr2:3824567 G/A cg17052675 chr2:3827356 NA -0.83 -20.1 -0.74 1.83e-59 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs57590327 0.503 rs6800295 chr3:81593011 A/G cg07356753 chr3:81810745 GBE1 -0.49 -6.61 -0.34 1.5e-10 Extraversion; LUSC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.83 0.63 1.46e-38 Platelet count; LUSC cis rs16912285 0.786 rs76326641 chr11:24253072 G/A ch.11.24196551F chr11:24239977 NA 0.72 6.09 0.32 3.05e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4654899 0.931 rs4654727 chr1:21214735 C/T cg01072550 chr1:21505969 NA 0.5 7.49 0.38 6.24e-13 Superior frontal gyrus grey matter volume; LUSC trans rs6582630 0.519 rs4406888 chr12:38293312 A/C cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs6138458 1.000 rs2387362 chr20:24899906 C/T cg06937882 chr20:24974362 C20orf3 0.42 7.0 0.36 1.43e-11 Blood protein levels; LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg05347473 chr6:146136440 FBXO30 0.45 7.7 0.39 1.61e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1801251 0.778 rs778340 chr2:233734083 C/T cg25237894 chr2:233734115 C2orf82 -0.36 -7.06 -0.36 9.61e-12 Coronary artery disease; LUSC cis rs1712517 0.836 rs11191649 chr10:105067037 T/C cg05636881 chr10:105038444 INA 0.38 6.22 0.32 1.47e-9 Migraine; LUSC trans rs2243480 1.000 rs1267820 chr7:66050295 C/G cg10756647 chr7:56101905 PSPH 0.89 9.05 0.44 1.19e-17 Diabetic kidney disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08393024 chr5:115177154 ATG12;AP3S1 -0.4 -6.13 -0.32 2.51e-9 Hepatitis; LUSC cis rs4077468 1.000 rs11801695 chr1:205916175 A/C cg24503407 chr1:205819492 PM20D1 0.44 6.31 0.33 8.95e-10 Cystic fibrosis-related diabetes; LUSC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg21724239 chr8:58056113 NA 0.56 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); LUSC cis rs2637266 0.714 rs7895605 chr10:78454207 G/A cg18941641 chr10:78392320 NA 0.33 5.97 0.31 5.95e-9 Pulmonary function; LUSC cis rs713477 0.967 rs6573029 chr14:55913550 A/C cg13175173 chr14:55914753 NA -0.3 -6.28 -0.32 1.08e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs11098499 0.618 rs35265692 chr4:120325135 T/C cg09307838 chr4:120376055 NA 0.77 11.14 0.52 9.92e-25 Corneal astigmatism; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28374715 0.662 rs10851403 chr15:41466087 T/G cg18705301 chr15:41695430 NDUFAF1 -0.85 -14.98 -0.63 3.53e-39 Ulcerative colitis; LUSC cis rs2677744 0.626 rs3743452 chr15:91497515 C/T cg22570213 chr15:91497863 RCCD1 -0.38 -5.77 -0.3 1.81e-8 Attention deficit hyperactivity disorder; LUSC cis rs4588572 0.644 rs1159930 chr5:77768943 C/T cg11547950 chr5:77652471 NA 0.46 6.77 0.35 5.72e-11 Triglycerides; LUSC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg01097406 chr16:89675127 NA -0.37 -7.34 -0.37 1.63e-12 Vitiligo; LUSC cis rs400736 0.894 rs226242 chr1:8033468 G/A cg25007680 chr1:8021821 PARK7 0.59 9.3 0.45 1.95e-18 Response to antidepressants and depression; LUSC cis rs394563 0.559 rs13219868 chr6:149686518 T/G cg03678062 chr6:149772716 ZC3H12D 0.31 6.32 0.33 8.59e-10 Dupuytren's disease; LUSC cis rs1775715 0.707 rs1541262 chr10:32179771 A/G cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.65e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 13.91 0.61 5.25e-35 Platelet count; LUSC trans rs11098499 0.780 rs7692994 chr4:120427489 C/A cg25214090 chr10:38739885 LOC399744 0.5 7.6 0.38 2.98e-13 Corneal astigmatism; LUSC cis rs3741151 0.773 rs7925226 chr11:73137362 A/G cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9311171 0.689 rs6775702 chr3:37972794 A/T cg12605080 chr3:37966887 CTDSPL 0.33 6.06 0.31 3.72e-9 Prostate cancer; LUSC cis rs7208859 0.623 rs12103508 chr17:29086781 T/G cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg21782813 chr7:2030301 MAD1L1 0.45 7.46 0.38 7.56e-13 Bipolar disorder and schizophrenia; LUSC cis rs8017423 0.647 rs12882575 chr14:90820454 C/G cg04374321 chr14:90722782 PSMC1 -0.44 -6.63 -0.34 1.34e-10 Mortality in heart failure; LUSC cis rs931127 0.666 rs7932857 chr11:65457493 A/C cg05805236 chr11:65401703 PCNXL3 -0.42 -7.3 -0.37 2.13e-12 Systemic lupus erythematosus; LUSC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11890956 chr21:40555474 PSMG1 1.04 21.37 0.76 1.82e-64 Cognitive function; LUSC cis rs11971779 0.680 rs7801613 chr7:139039927 A/G cg23387468 chr7:139079360 LUC7L2 -0.45 -6.71 -0.34 8.3e-11 Diisocyanate-induced asthma; LUSC cis rs2637266 0.655 rs10824436 chr10:78457848 T/C cg18941641 chr10:78392320 NA 0.33 5.85 0.3 1.2e-8 Pulmonary function; LUSC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.16 0.32 2.11e-9 Mean platelet volume; LUSC cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg21466736 chr12:48725269 NA -0.33 -5.75 -0.3 2.06e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg26924012 chr15:45694286 SPATA5L1 -1.06 -18.71 -0.72 6.31e-54 Homoarginine levels; LUSC cis rs2439831 0.681 rs2278858 chr15:43632755 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.96 11.1 0.52 1.4e-24 Lung cancer in ever smokers; LUSC cis rs1847202 0.717 rs13063437 chr3:72952388 A/G cg25664220 chr3:72788482 NA -0.44 -7.94 -0.4 3.04e-14 Motion sickness; LUSC cis rs721399 0.568 rs7816847 chr8:18275189 A/C cg18736775 chr8:18248649 NAT2 -0.54 -6.54 -0.34 2.36e-10 Blood metabolite levels; LUSC cis rs10782582 0.593 rs77733234 chr1:76101655 A/T cg10523679 chr1:76189770 ACADM -0.49 -7.25 -0.37 2.94e-12 Daytime sleep phenotypes; LUSC cis rs9325144 0.560 rs11183046 chr12:38655270 A/T cg13010199 chr12:38710504 ALG10B -0.51 -7.67 -0.39 1.87e-13 Morning vs. evening chronotype; LUSC cis rs9581857 0.556 rs9581863 chr13:28040171 A/G cg22138327 chr13:27999177 GTF3A 0.7 9.5 0.46 4.1e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg13902645 chr11:5959945 NA -0.67 -10.81 -0.51 1.49e-23 DNA methylation (variation); LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg27170947 chr2:26402098 FAM59B -0.66 -9.54 -0.46 3.21e-19 Gut microbiome composition (summer); LUSC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg18681998 chr4:17616180 MED28 0.77 13.73 0.6 2.53e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg04267008 chr7:1944627 MAD1L1 -0.49 -7.28 -0.37 2.35e-12 Bipolar disorder and schizophrenia; LUSC cis rs11603020 0.950 rs28362949 chr11:57371911 G/T cg23127183 chr11:57508653 C11orf31 -0.46 -6.39 -0.33 5.63e-10 Blood protein levels; LUSC cis rs2637266 0.846 rs2637260 chr10:78320346 C/T cg18941641 chr10:78392320 NA -0.4 -7.6 -0.38 2.98e-13 Pulmonary function; LUSC cis rs7829975 0.623 rs7010753 chr8:8373956 A/G cg14343924 chr8:8086146 FLJ10661 0.43 6.14 0.32 2.41e-9 Mood instability; LUSC trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg15704280 chr7:45808275 SEPT13 -0.9 -13.87 -0.6 7.52e-35 Coronary artery disease; LUSC cis rs7493 0.950 rs7802171 chr7:95030321 A/G cg04871131 chr7:94954202 PON1 -0.4 -6.16 -0.32 2.07e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs710216 0.957 rs710215 chr1:43429105 T/C cg03128534 chr1:43423976 SLC2A1 0.47 5.86 0.31 1.13e-8 Red cell distribution width; LUSC trans rs2204008 0.744 rs11514358 chr12:38255526 G/A cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC trans rs1493916 0.748 rs4799355 chr18:31313124 G/T cg13755796 chr4:20253514 NA -0.38 -6.01 -0.31 4.92e-9 Life satisfaction; LUSC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg22800045 chr5:56110881 MAP3K1 0.76 9.84 0.47 3.24e-20 Initial pursuit acceleration; LUSC cis rs1832871 0.711 rs76962726 chr6:158674041 C/T cg07165851 chr6:158734300 TULP4 0.52 7.89 0.4 4.29e-14 Height; LUSC cis rs9633740 0.945 rs6586030 chr10:82254047 C/T cg01528321 chr10:82214614 TSPAN14 -1.05 -10.84 -0.51 1.12e-23 Post bronchodilator FEV1; LUSC cis rs3806843 1.000 rs1548700 chr5:140164889 A/T cg26395211 chr5:140044315 WDR55 -0.39 -6.0 -0.31 5.16e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 0.934 rs6465344 chr7:91640273 G/A cg17063962 chr7:91808500 NA 0.57 9.07 0.44 1.02e-17 Breast cancer; LUSC cis rs11608355 0.846 rs4766472 chr12:109853602 C/G cg19025524 chr12:109796872 NA -0.39 -5.72 -0.3 2.35e-8 Neuroticism; LUSC cis rs10979 1.000 rs9386034 chr6:143890572 T/G cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg18964960 chr10:1102726 WDR37 -0.47 -6.29 -0.33 9.85e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg11062466 chr8:58055876 NA 0.51 6.9 0.35 2.67e-11 Developmental language disorder (linguistic errors); LUSC cis rs477692 0.935 rs557158 chr10:131420534 C/T cg05714579 chr10:131428358 MGMT 0.49 7.32 0.37 1.82e-12 Response to temozolomide; LUSC cis rs3760982 0.565 rs8104300 chr19:44293144 T/C cg11993925 chr19:44307056 LYPD5 0.35 7.56 0.38 4.02e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs8032315 0.965 rs12906125 chr15:91427612 G/A cg05469396 chr15:91419421 FURIN -0.43 -6.69 -0.34 9.7e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs10791097 0.967 rs1944142 chr11:130717440 C/T cg12179176 chr11:130786555 SNX19 0.65 9.99 0.48 9.51e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs1493916 0.967 rs9953765 chr18:31399464 A/G cg27147174 chr7:100797783 AP1S1 -0.64 -10.28 -0.49 1.02e-21 Life satisfaction; LUSC cis rs367615 0.661 rs9326775 chr5:108836925 A/T cg17395555 chr5:108820864 NA 0.63 11.42 0.53 9.71e-26 Colorectal cancer (SNP x SNP interaction); LUSC cis rs7474896 0.559 rs1208645 chr10:38132087 C/T cg25427524 chr10:38739819 LOC399744 0.42 5.68 0.3 2.93e-8 Obesity (extreme); LUSC trans rs3733585 0.699 rs7657340 chr4:9966772 A/T cg26043149 chr18:55253948 FECH -0.46 -7.1 -0.36 7.46e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8062405 1.000 rs7498665 chr16:28883241 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs3733418 0.929 rs4690797 chr4:165908505 G/C cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -5.92 -0.31 7.89e-9 Obesity-related traits; LUSC trans rs877282 0.945 rs10904555 chr10:787740 C/A cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg07959070 chr22:50026188 C22orf34 -0.34 -6.97 -0.36 1.7e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.46e-10 Body mass index; LUSC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg25036284 chr2:26402008 FAM59B -0.71 -10.02 -0.48 7.79e-21 Gut microbiome composition (summer); LUSC cis rs2115536 0.692 rs6495451 chr15:80164053 C/T cg00225070 chr15:80189496 MTHFS 0.43 6.23 0.32 1.41e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg05861140 chr6:150128134 PCMT1 -0.39 -6.03 -0.31 4.46e-9 Lung cancer; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03352830 chr11:487213 PTDSS2 0.72 8.67 0.43 1.85e-16 Body mass index; LUSC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.9 0.44 3.66e-17 Schizophrenia; LUSC cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg21466736 chr12:48725269 NA -0.33 -5.76 -0.3 1.92e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1003719 0.788 rs2835595 chr21:38466203 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs11122272 0.735 rs2739518 chr1:231537633 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.96 -0.48 1.29e-20 Hemoglobin concentration; LUSC cis rs929354 0.629 rs6950739 chr7:156982450 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.08 0.58 7.24e-32 Body mass index; LUSC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11890956 chr21:40555474 PSMG1 1.03 20.61 0.75 1.8e-61 Cognitive function; LUSC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg06238570 chr21:40685208 BRWD1 -0.59 -9.22 -0.45 3.36e-18 Menarche (age at onset); LUSC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg14416269 chr4:6271139 WFS1 0.54 11.47 0.53 6.87e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg07930552 chr6:133119739 C6orf192 0.76 10.15 0.49 2.73e-21 Type 2 diabetes nephropathy; LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg05368731 chr17:41323189 NBR1 0.93 16.21 0.66 5.4e-44 Menopause (age at onset); LUSC cis rs9527 0.615 rs11191485 chr10:104729816 G/C cg04362960 chr10:104952993 NT5C2 0.6 9.47 0.46 5.21e-19 Arsenic metabolism; LUSC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg06742321 chr12:123595122 PITPNM2 0.39 5.83 0.3 1.28e-8 Platelet count; LUSC trans rs1908814 0.516 rs4367597 chr8:11793529 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.61e-9 Neuroticism; LUSC cis rs5769765 1.000 rs2092982 chr22:50282204 C/A cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.69 0.5 3.96e-23 Schizophrenia; LUSC cis rs858239 0.539 rs1358442 chr7:23189739 C/T cg23682824 chr7:23144976 KLHL7 0.4 5.71 0.3 2.52e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg11764359 chr7:65958608 NA -0.78 -12.94 -0.58 2.46e-31 Aortic root size; LUSC cis rs3820068 0.705 rs11583306 chr1:15860803 A/G cg17385448 chr1:15911702 AGMAT -0.38 -5.91 -0.31 8.36e-9 Systolic blood pressure; LUSC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.836 rs1549016 chr2:15616859 G/A cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg24562669 chr7:97807699 LMTK2 0.34 5.95 0.31 6.83e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg22029157 chr1:209979665 IRF6 -0.68 -11.68 -0.54 1.15e-26 Monobrow; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs72781680 0.898 rs72780118 chr2:23994431 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs12318506 0.826 rs13377894 chr12:75661825 A/G cg04728562 chr12:75699417 CAPS2 -0.77 -5.93 -0.31 7.49e-9 Coronary artery calcification; LUSC trans rs11039798 0.623 rs7294273 chr11:48705374 T/C cg15704280 chr7:45808275 SEPT13 0.73 8.29 0.41 2.88e-15 Axial length; LUSC cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg13256891 chr4:100009986 ADH5 0.46 6.84 0.35 3.78e-11 Alcohol dependence; LUSC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4655582 0.510 rs12022410 chr1:66153933 A/G cg04111102 chr1:66153794 NA 0.27 5.79 0.3 1.65e-8 Fibrinogen levels; LUSC cis rs7582180 0.715 rs7571306 chr2:100906084 G/C cg08017756 chr2:100939284 LONRF2 -0.4 -7.35 -0.37 1.51e-12 Intelligence (multi-trait analysis); LUSC cis rs16912285 0.591 rs7929025 chr11:24363324 A/C ch.11.24196551F chr11:24239977 NA 0.78 8.16 0.41 6.79e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs244293 0.730 rs9303362 chr17:53062553 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.38 -5.71 -0.3 2.54e-8 Menarche (age at onset); LUSC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg11742103 chr11:62369870 EML3;MTA2 0.55 9.02 0.44 1.54e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1577917 0.958 rs10944144 chr6:86537755 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.79 -0.35 5.14e-11 Response to antipsychotic treatment; LUSC cis rs2625529 0.730 rs982752 chr15:72145937 C/T cg16672083 chr15:72433130 SENP8 -0.48 -7.72 -0.39 1.38e-13 Red blood cell count; LUSC cis rs2797160 0.904 rs2326292 chr6:125999674 G/A cg05901451 chr6:126070800 HEY2 -0.6 -9.07 -0.44 1.03e-17 Endometrial cancer; LUSC cis rs61931739 0.890 rs1687020 chr12:34137924 G/C cg06521331 chr12:34319734 NA -0.37 -6.22 -0.32 1.46e-9 Morning vs. evening chronotype; LUSC cis rs500891 0.553 rs7758546 chr6:84135023 G/C cg08257003 chr6:84140564 ME1 0.37 9.17 0.45 5.06e-18 Platelet-derived growth factor BB levels; LUSC cis rs7561273 0.586 rs6545264 chr2:24310105 A/G cg06627628 chr2:24431161 ITSN2 -0.51 -6.84 -0.35 3.85e-11 Quantitative traits; LUSC cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg05472934 chr7:22766657 IL6 0.44 6.99 0.36 1.49e-11 Lung cancer; LUSC cis rs7312933 0.558 rs61926593 chr12:42818912 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.87 0.35 3.15e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg26335602 chr6:28129616 ZNF389 -0.42 -5.73 -0.3 2.21e-8 Depression; LUSC cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg11244672 chr19:19639970 YJEFN3 0.58 7.31 0.37 2.04e-12 Bipolar disorder; LUSC cis rs897984 0.806 rs11640534 chr16:30949515 G/A cg02466173 chr16:30829666 NA 0.57 11.43 0.53 9.44e-26 Dementia with Lewy bodies; LUSC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.52 0.34 2.54e-10 Schizophrenia; LUSC cis rs12210905 0.925 rs9467965 chr6:26992539 G/C cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.99 -0.31 5.28e-9 Hip circumference adjusted for BMI; LUSC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg22875332 chr1:76189707 ACADM -0.76 -10.33 -0.49 6.8e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.5 0.53 5.21e-26 Prudent dietary pattern; LUSC cis rs56283067 0.887 rs12200892 chr6:44768925 T/C cg20913747 chr6:44695427 NA -0.48 -7.43 -0.38 9.45e-13 Total body bone mineral density; LUSC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg19230755 chr7:65878503 NA 0.41 5.75 0.3 2e-8 Aortic root size; LUSC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg05855489 chr10:104503620 C10orf26 -0.69 -10.09 -0.48 4.4e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg17264618 chr3:40429014 ENTPD3 0.37 7.77 0.39 9.49e-14 Renal cell carcinoma; LUSC cis rs897984 0.762 rs1870293 chr16:30970941 T/C cg02466173 chr16:30829666 NA 0.56 10.92 0.51 5.93e-24 Dementia with Lewy bodies; LUSC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg12463550 chr7:65579703 CRCP -0.52 -7.63 -0.39 2.43e-13 Aortic root size; LUSC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg23758822 chr17:41437982 NA -1.06 -20.02 -0.74 3.96e-59 Menopause (age at onset); LUSC trans rs724744 0.740 rs1772077 chr6:22353749 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.19 -0.32 1.77e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg06671706 chr8:8559999 CLDN23 0.5 6.86 0.35 3.37e-11 Obesity-related traits; LUSC cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg26597838 chr10:835615 NA 0.91 12.54 0.57 8.07e-30 Eosinophil percentage of granulocytes; LUSC trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg15704280 chr7:45808275 SEPT13 0.56 6.89 0.35 2.71e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs9393777 0.623 rs56296968 chr6:26474571 C/T cg12292205 chr6:26970375 C6orf41 -0.63 -7.57 -0.38 3.72e-13 Intelligence (multi-trait analysis); LUSC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg05872129 chr22:39784769 NA -0.59 -10.34 -0.49 6.14e-22 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg15017067 chr4:17643749 FAM184B 0.35 5.81 0.3 1.49e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs17125944 0.572 rs79312783 chr14:53250296 A/T cg00686598 chr14:53173677 PSMC6 1.26 11.09 0.52 1.56e-24 Alzheimer's disease (late onset); LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg16325326 chr1:53192061 ZYG11B 0.81 14.0 0.61 2.39e-35 Monocyte count; LUSC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg16405210 chr4:1374714 KIAA1530 -0.6 -9.32 -0.45 1.69e-18 Longevity; LUSC trans rs67539049 1.000 rs67350204 chr8:11300293 A/G cg26241650 chr22:40417538 FAM83F 0.45 6.02 0.31 4.71e-9 Itch intensity from mosquito bite; LUSC cis rs7809950 0.817 rs2237671 chr7:107131528 A/T cg23024343 chr7:107201750 COG5 -0.69 -10.34 -0.49 6.28e-22 Coronary artery disease; LUSC cis rs8114671 0.869 rs6060199 chr20:33654773 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -5.89 -0.31 9.23e-9 Height; LUSC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.07 -0.48 5.1e-21 Obesity-related traits; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg13395646 chr4:1353034 KIAA1530 -0.56 -8.38 -0.42 1.54e-15 Longevity; LUSC cis rs637571 0.522 rs606978 chr11:65711517 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 9.42 0.46 7.79e-19 Eosinophil percentage of white cells; LUSC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg23625390 chr15:77176239 SCAPER 0.47 7.2 0.37 4.11e-12 Blood metabolite levels; LUSC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg03060546 chr3:49711283 APEH 0.71 11.95 0.55 1.23e-27 Resting heart rate; LUSC cis rs17270561 0.609 rs1317816 chr6:25765390 T/C cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg09904177 chr6:26538194 HMGN4 -0.71 -12.37 -0.56 3.45e-29 Intelligence (multi-trait analysis); LUSC cis rs7131987 0.934 rs2216854 chr12:29423460 G/A cg09582351 chr12:29534625 ERGIC2 -0.3 -6.37 -0.33 6.43e-10 QT interval; LUSC cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs7246657 0.943 rs10420722 chr19:37973774 C/G cg23950597 chr19:37808831 NA -0.63 -7.41 -0.38 1.05e-12 Coronary artery calcification; LUSC cis rs17401966 0.931 rs12130563 chr1:10428452 G/A cg19773385 chr1:10388646 KIF1B -0.57 -9.86 -0.47 2.77e-20 Hepatocellular carcinoma; LUSC cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg15103426 chr22:29168792 CCDC117 0.45 5.84 0.3 1.26e-8 Lymphocyte counts; LUSC cis rs8044868 0.561 rs3909542 chr16:72183505 C/T cg16579770 chr16:72058938 DHODH 0.35 5.84 0.3 1.25e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg10018233 chr7:150070692 REPIN1 0.4 7.08 0.36 8.65e-12 Blood protein levels;Circulating chemerin levels; LUSC trans rs2739330 0.627 rs9608219 chr22:24274119 G/C cg06437703 chr8:37914619 EIF4EBP1 -0.64 -10.51 -0.5 1.7e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23621158 chr4:83206416 NA -0.39 -5.96 -0.31 6.36e-9 Electrocardiographic conduction measures; LUSC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg12615879 chr12:58013172 SLC26A10 -0.28 -5.93 -0.31 7.62e-9 Multiple sclerosis; LUSC cis rs6577655 0.501 rs879104 chr8:135609537 G/A cg17885191 chr8:135476712 NA 0.42 5.76 0.3 1.91e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7582180 0.614 rs10193204 chr2:101004540 A/G cg08017756 chr2:100939284 LONRF2 0.42 7.78 0.39 8.95e-14 Intelligence (multi-trait analysis); LUSC cis rs6537837 1.000 rs7355157 chr1:110129835 T/C cg05049280 chr1:110155535 GNAT2 0.51 6.94 0.36 2e-11 Major depressive disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13099106 chr12:120525172 CCDC64 0.46 6.64 0.34 1.3e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs208520 0.754 rs1100989 chr6:66880532 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -16.25 -0.66 3.52e-44 Exhaled nitric oxide output; LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20592700 chr7:5230083 WIPI2 -0.5 -6.75 -0.35 6.49e-11 Bipolar disorder and schizophrenia; LUSC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg13175981 chr1:150552382 MCL1 0.54 7.64 0.39 2.37e-13 Tonsillectomy; LUSC cis rs4148883 0.651 rs4147547 chr4:100127311 G/T cg12011299 chr4:100065546 ADH4 0.47 7.81 0.39 7.33e-14 Alcohol dependence; LUSC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg07716408 chr11:68623521 NA 0.32 6.13 0.32 2.5e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11098499 0.909 rs71614422 chr4:120359340 G/A cg24375607 chr4:120327624 NA 0.79 11.78 0.54 5.25e-27 Corneal astigmatism; LUSC cis rs61931739 0.500 rs11053207 chr12:34459827 A/G cg06521331 chr12:34319734 NA -0.41 -6.75 -0.35 6.42e-11 Morning vs. evening chronotype; LUSC trans rs1864729 1.000 rs1431891 chr8:98282716 A/G cg08679828 chr8:102218111 ZNF706 -0.87 -7.9 -0.4 3.95e-14 Estradiol plasma levels (breast cancer); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04830409 chr12:64615927 C12orf66 0.4 5.99 0.31 5.41e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs77106637 1.000 rs3862791 chr11:72501002 C/T cg03878208 chr11:72483293 STARD10 0.57 7.28 0.37 2.33e-12 Type 2 diabetes; LUSC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs10266483 0.739 rs12538943 chr7:63856368 G/A cg24201672 chr7:64023550 ZNF680 0.49 5.89 0.31 9.36e-9 Response to statin therapy; LUSC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg24209194 chr3:40518798 ZNF619 -0.45 -6.33 -0.33 7.78e-10 Renal cell carcinoma; LUSC cis rs9469578 0.710 rs73743330 chr6:33713971 G/A cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg06008330 chr7:65541103 ASL 0.4 6.18 0.32 1.85e-9 Aortic root size; LUSC cis rs727505 0.819 rs4142718 chr7:124731688 T/A cg23710748 chr7:124431027 NA -0.4 -6.97 -0.36 1.73e-11 Lewy body disease; LUSC cis rs7666738 0.606 rs3846446 chr4:99099768 C/A cg05340658 chr4:99064831 C4orf37 0.58 9.5 0.46 4.19e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs62400317 0.859 rs12198376 chr6:45153681 G/C cg20913747 chr6:44695427 NA -0.47 -7.46 -0.38 7.32e-13 Total body bone mineral density; LUSC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18758796 chr5:131593413 PDLIM4 0.53 9.2 0.45 3.99e-18 Acylcarnitine levels; LUSC cis rs113835537 0.559 rs11227497 chr11:66269464 T/C cg24851651 chr11:66362959 CCS 0.55 8.26 0.41 3.47e-15 Airway imaging phenotypes; LUSC cis rs2219968 0.961 rs2128016 chr8:78964507 C/T cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs17270561 0.609 rs6941933 chr6:25745702 T/C cg16482183 chr6:26056742 HIST1H1C 0.64 9.23 0.45 3.26e-18 Iron status biomarkers; LUSC cis rs911119 0.779 rs3761280 chr20:23620076 A/G cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.27 -0.37 2.51e-12 Bipolar disorder; LUSC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg18404041 chr3:52824283 ITIH1 -0.57 -9.6 -0.47 1.98e-19 Schizophrenia; LUSC cis rs3820068 0.608 rs12092485 chr1:16048038 A/G cg13390004 chr1:15929781 NA 0.4 6.46 0.33 3.61e-10 Systolic blood pressure; LUSC cis rs782590 0.574 rs12991445 chr2:55675939 C/T cg03859395 chr2:55845619 SMEK2 0.66 9.94 0.48 1.51e-20 Metabolic syndrome; LUSC cis rs709400 0.628 rs12879085 chr14:103874420 G/A cg12935359 chr14:103987150 CKB 0.52 8.12 0.41 8.93e-15 Body mass index; LUSC cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg16230307 chr14:35515116 FAM177A1 0.78 10.0 0.48 8.96e-21 Psoriasis; LUSC cis rs4499344 0.805 rs12978075 chr19:33067852 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.61 -7.75 -0.39 1.12e-13 Mean platelet volume; LUSC cis rs7592578 0.766 rs62182865 chr2:191434180 T/C cg11845111 chr2:191398756 TMEM194B -0.89 -11.0 -0.52 3.1e-24 Diastolic blood pressure; LUSC cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 7.98 0.4 2.31e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg09359103 chr1:154839909 KCNN3 0.68 15.29 0.64 2.2e-40 Prostate cancer; LUSC cis rs12310956 0.532 rs1852226 chr12:33962940 G/A cg06521331 chr12:34319734 NA -0.45 -7.28 -0.37 2.4e-12 Morning vs. evening chronotype; LUSC cis rs2361710 0.611 rs12451471 chr17:78102517 C/T cg24585782 chr17:78113791 EIF4A3 -0.44 -6.65 -0.34 1.18e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs427941 0.703 rs10953358 chr7:101738226 T/C cg06246474 chr7:101738831 CUX1 -0.41 -6.71 -0.34 8.45e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs1797081 0.561 rs2603795 chr10:16860256 A/G cg14835575 chr10:16859367 RSU1 0.39 5.79 0.3 1.6e-8 Platelet distribution width; LUSC cis rs6964587 0.934 rs7811328 chr7:91720931 A/T cg22709100 chr7:91322751 NA 0.4 5.9 0.31 8.7e-9 Breast cancer; LUSC trans rs61931739 0.517 rs4931771 chr12:34044557 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 2.92e-25 Morning vs. evening chronotype; LUSC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs6500395 0.735 rs74017013 chr16:48664120 G/A cg04672837 chr16:48644449 N4BP1 0.47 7.02 0.36 1.22e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg25072359 chr17:41440525 NA 0.62 8.88 0.44 4.23e-17 Menopause (age at onset); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg13325330 chr6:44355541 CDC5L 0.49 5.98 0.31 5.86e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.11 -0.45 7.8e-18 Monocyte percentage of white cells; LUSC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg26566898 chr11:117069891 TAGLN -0.47 -8.33 -0.41 2.06e-15 Blood protein levels; LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs9788721 0.836 rs2656065 chr15:78750549 G/A cg18825076 chr15:78729989 IREB2 -0.63 -10.36 -0.49 5.6e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.93 15.0 0.63 2.96e-39 Multiple sclerosis; LUSC cis rs4423214 0.559 rs10898201 chr11:71201527 C/A cg05163923 chr11:71159392 DHCR7 -0.65 -7.1 -0.36 7.41e-12 Vitamin D levels; LUSC cis rs4722166 0.630 rs6461667 chr7:22796743 A/G cg05472934 chr7:22766657 IL6 0.54 8.41 0.42 1.2e-15 Lung cancer; LUSC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg04025307 chr7:1156635 C7orf50 0.44 6.06 0.31 3.75e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1346 0.580 rs7937415 chr11:65363958 A/G cg17120908 chr11:65337727 SSSCA1 -0.4 -5.7 -0.3 2.62e-8 Vertical cup-disc ratio;Optic cup area; LUSC cis rs3126085 0.877 rs4415568 chr1:152181207 G/A cg03465714 chr1:152285911 FLG -0.43 -5.94 -0.31 7.27e-9 Atopic dermatitis; LUSC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg06008330 chr7:65541103 ASL -0.41 -6.45 -0.33 3.81e-10 Aortic root size; LUSC cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg01849466 chr14:104193079 ZFYVE21 -0.6 -9.91 -0.48 1.82e-20 Schizophrenia; LUSC cis rs9300255 0.602 rs1727294 chr12:123616514 A/G cg05973401 chr12:123451056 ABCB9 0.54 6.77 0.35 5.69e-11 Neutrophil percentage of white cells; LUSC trans rs57221529 0.766 rs17497684 chr5:558307 T/C cg11887960 chr12:57824829 NA 0.55 7.21 0.37 3.7e-12 Lung disease severity in cystic fibrosis; LUSC trans rs3857536 0.813 rs7757118 chr6:66946661 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs7799006 0.606 rs34262822 chr7:2304275 C/T cg12823233 chr7:2316876 SNX8 -0.44 -7.49 -0.38 6.02e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs7819412 0.659 rs4073948 chr8:10772644 A/T cg15556689 chr8:8085844 FLJ10661 -0.55 -7.71 -0.39 1.41e-13 Triglycerides; LUSC trans rs35110281 0.627 rs11701746 chr21:44975137 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.84 0.47 3.04e-20 Mean corpuscular volume; LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.65 0.76 1.42e-65 Prudent dietary pattern; LUSC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg22437258 chr11:111473054 SIK2 0.5 6.83 0.35 4.12e-11 Primary sclerosing cholangitis; LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 13.55 0.6 1.22e-33 Platelet count; LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg15112475 chr7:1198522 ZFAND2A -0.34 -7.22 -0.37 3.43e-12 Longevity;Endometriosis; LUSC cis rs6489882 0.779 rs57484342 chr12:113371973 A/G cg20102336 chr12:113376681 OAS3 -0.42 -6.1 -0.32 2.9e-9 Chronic lymphocytic leukemia; LUSC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg04398451 chr17:18023971 MYO15A -0.54 -9.06 -0.44 1.13e-17 Total body bone mineral density; LUSC cis rs765787 0.530 rs10467979 chr15:45521270 G/A cg24006582 chr15:45444508 DUOX1 -0.61 -8.97 -0.44 2.25e-17 Uric acid levels; LUSC cis rs7312933 0.531 rs1796380 chr12:42791543 T/G cg01256987 chr12:42539512 GXYLT1 0.36 6.69 0.34 9.16e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.77 0.3 1.81e-8 Cerebrospinal P-tau181p levels; LUSC cis rs4988958 0.565 rs3755265 chr2:103052816 C/A cg03938978 chr2:103052716 IL18RAP 0.37 7.2 0.37 4.1e-12 Asthma (childhood onset); LUSC cis rs7577851 0.716 rs66641893 chr2:69677296 T/G cg10773587 chr2:69614142 GFPT1 0.56 6.66 0.34 1.13e-10 Parkinson's disease (age of onset); LUSC cis rs7824557 0.603 rs2250028 chr8:11213589 T/G cg21775007 chr8:11205619 TDH 0.77 12.07 0.55 4.53e-28 Retinal vascular caliber; LUSC trans rs6601327 0.670 rs6990418 chr8:9422006 C/G cg15556689 chr8:8085844 FLJ10661 0.46 6.51 0.34 2.83e-10 Multiple myeloma (hyperdiploidy); LUSC trans rs7824557 0.592 rs920044 chr8:11224313 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.74 0.35 6.95e-11 Retinal vascular caliber; LUSC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21582582 chr3:182698605 DCUN1D1 0.47 8.11 0.41 9.55e-15 Intelligence (multi-trait analysis); LUSC cis rs117352156 1.000 rs10826546 chr10:29237462 C/T cg06394621 chr10:29236369 NA 0.46 5.75 0.3 2.06e-8 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs4803468 1.000 rs284648 chr19:41926790 T/C cg09537434 chr19:41945824 ATP5SL -0.92 -16.09 -0.66 1.58e-43 Height; LUSC cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg26395211 chr5:140044315 WDR55 -0.39 -5.95 -0.31 6.92e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg11764359 chr7:65958608 NA -0.69 -10.44 -0.5 2.96e-22 Aortic root size; LUSC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg19046167 chr17:80928561 B3GNTL1 0.49 6.96 0.36 1.77e-11 Glycated hemoglobin levels; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg10506160 chr16:11762778 SNN 0.48 5.99 0.31 5.58e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2086824 0.702 rs3114896 chr16:89393562 C/T cg02187348 chr16:89574699 SPG7 -0.4 -6.09 -0.32 3.19e-9 Multiple myeloma (IgH translocation); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22886512 chr19:8408083 KANK3 -0.48 -6.2 -0.32 1.63e-9 Bipolar disorder and schizophrenia; LUSC cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg18850127 chr7:39170497 POU6F2 0.64 9.83 0.47 3.28e-20 IgG glycosylation; LUSC cis rs7598759 0.604 rs4973407 chr2:232311639 G/A cg19187155 chr2:232395269 NMUR1 0.4 5.73 0.3 2.28e-8 Noise-induced hearing loss; LUSC cis rs9479482 0.967 rs61730071 chr6:150342232 G/A cg07578070 chr6:150326732 RAET1K 0.38 5.84 0.3 1.24e-8 Alopecia areata; LUSC cis rs1371867 0.810 rs2860518 chr8:101238120 G/T cg06636551 chr8:101224915 SPAG1 0.43 8.14 0.41 8.19e-15 Atrioventricular conduction; LUSC cis rs9393777 0.623 rs3757150 chr6:26476782 T/A cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.645 rs28445479 chr11:50047999 A/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg05100916 chr7:112090586 IFRD1 0.5 7.16 0.36 5.33e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6696846 0.729 rs72757512 chr1:205079203 G/A cg21643547 chr1:205240462 TMCC2 -0.42 -7.65 -0.39 2.17e-13 Red blood cell count; LUSC cis rs9467773 0.587 rs10946813 chr6:26345141 A/G cg09904177 chr6:26538194 HMGN4 0.5 8.04 0.4 1.61e-14 Intelligence (multi-trait analysis); LUSC cis rs1865760 1.000 rs2071297 chr6:25924513 C/G cg17691542 chr6:26056736 HIST1H1C -0.44 -6.73 -0.35 7.61e-11 Height; LUSC cis rs7107174 1.000 rs2450122 chr11:77930345 T/C cg02023728 chr11:77925099 USP35 0.51 7.27 0.37 2.59e-12 Testicular germ cell tumor; LUSC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 -0.9 -14.81 -0.63 1.62e-38 Platelet count; LUSC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg13319975 chr6:146136371 FBXO30 -0.49 -7.27 -0.37 2.55e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC trans rs4714291 0.802 rs2983140 chr6:40017224 A/G cg02267698 chr19:7991119 CTXN1 -0.54 -7.88 -0.4 4.79e-14 Strep throat; LUSC cis rs6076065 0.723 rs2424531 chr20:23372754 C/T cg11657817 chr20:23433608 CST11 -0.42 -8.06 -0.4 1.34e-14 Facial morphology (factor 15, philtrum width); LUSC trans rs61931739 0.534 rs7302688 chr12:34235064 A/G cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.35e-16 Morning vs. evening chronotype; LUSC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg15445000 chr17:37608096 MED1 -0.38 -6.55 -0.34 2.15e-10 Glomerular filtration rate (creatinine); LUSC cis rs7212938 0.509 rs3893044 chr17:38103016 C/T cg26162295 chr17:38119207 GSDMA 0.29 7.06 0.36 9.85e-12 Asthma and hay fever; LUSC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg23887609 chr12:130822674 PIWIL1 0.48 7.1 0.36 7.75e-12 Menopause (age at onset); LUSC cis rs4595586 0.545 rs61939641 chr12:39378001 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs6700896 0.864 rs56274111 chr1:66128511 A/C cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg15112475 chr7:1198522 ZFAND2A -0.32 -6.62 -0.34 1.41e-10 Longevity;Endometriosis; LUSC cis rs9399401 0.626 rs4304190 chr6:142778912 A/G cg03128060 chr6:142623767 GPR126 0.58 9.63 0.47 1.55e-19 Chronic obstructive pulmonary disease; LUSC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg10117171 chr1:25599238 RHD -0.39 -6.02 -0.31 4.57e-9 Erythrocyte sedimentation rate; LUSC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.46 7.04 0.36 1.09e-11 Colorectal cancer; LUSC cis rs7605827 0.930 rs7596969 chr2:15513615 C/G cg19274914 chr2:15703543 NA -0.46 -8.84 -0.44 5.43e-17 Educational attainment (years of education); LUSC cis rs11105298 0.786 rs10777186 chr12:89921277 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.42 -0.38 1.01e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg00701064 chr4:6280414 WFS1 0.59 14.09 0.61 1.05e-35 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs10266483 0.774 rs7796802 chr7:63784122 G/A cg24201672 chr7:64023550 ZNF680 0.45 5.82 0.3 1.34e-8 Response to statin therapy; LUSC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg12927641 chr6:109611667 NA -0.43 -7.59 -0.38 3.21e-13 Reticulocyte fraction of red cells; LUSC cis rs12711979 0.509 rs10195488 chr2:3824135 T/C cg17052675 chr2:3827356 NA -0.83 -20.1 -0.74 1.83e-59 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs4820539 0.966 rs5751590 chr22:23486830 A/C cg14186256 chr22:23484241 RTDR1 0.96 18.0 0.7 4.08e-51 Bone mineral density; LUSC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg03188948 chr7:1209495 NA 0.65 6.89 0.35 2.73e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7953249 0.564 rs11065385 chr12:121423386 A/G cg02403541 chr12:121454288 C12orf43 -0.71 -10.82 -0.51 1.4e-23 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC trans rs9693857 1.000 rs9693857 chr8:9267117 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -7.96 -0.4 2.74e-14 Systolic blood pressure; LUSC cis rs1009647 0.645 rs67773067 chr14:55697207 G/T cg04306507 chr14:55594613 LGALS3 0.43 5.76 0.3 1.94e-8 Testicular germ cell tumor; LUSC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs2273669 0.667 rs11153153 chr6:109356104 A/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 9.1e-9 Prostate cancer; LUSC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 5.69 0.3 2.81e-8 Aortic root size; LUSC trans rs9393777 0.841 rs67092078 chr6:27054772 G/A cg06606381 chr12:133084897 FBRSL1 -0.96 -8.38 -0.42 1.53e-15 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05062854 chr22:32435553 NA 0.44 6.77 0.35 5.63e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10163222 chr19:45004637 ZNF180 -0.43 -6.58 -0.34 1.86e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs7829975 0.606 rs6422352 chr8:8794193 A/G cg21775007 chr8:11205619 TDH -0.41 -6.15 -0.32 2.16e-9 Mood instability; LUSC cis rs7267979 0.966 rs4815425 chr20:25398876 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15561356 chr20:61904111 ARFGAP1 -0.41 -6.19 -0.32 1.72e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs240768 1.000 rs240782 chr6:100965257 G/C cg12253828 chr6:101329408 ASCC3 0.84 5.86 0.31 1.13e-8 Economic and political preferences (immigration/crime); LUSC trans rs11700980 1.000 rs73898414 chr21:30125196 C/T cg05609335 chr17:75789393 NA 0.41 6.32 0.33 8.58e-10 QRS complex (12-leadsum); LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18404041 chr3:52824283 ITIH1 -0.46 -8.49 -0.42 7.02e-16 Electroencephalogram traits; LUSC cis rs7572644 0.766 rs13003383 chr2:28235763 C/T cg27432699 chr2:27873401 GPN1 0.53 6.55 0.34 2.19e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs372883 0.648 rs368322 chr21:30717151 C/T cg24692254 chr21:30365293 RNF160 -0.67 -10.06 -0.48 5.91e-21 Pancreatic cancer; LUSC cis rs4285028 0.747 rs9850439 chr3:121393075 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.81 -0.57 8.07e-31 Multiple sclerosis; LUSC cis rs12989701 0.877 rs71414738 chr2:127876242 C/T cg08168897 chr2:127865431 BIN1 0.73 9.32 0.45 1.65e-18 Alzheimer's disease (late onset); LUSC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg02753203 chr1:228287806 NA 0.68 11.6 0.54 2.24e-26 Diastolic blood pressure; LUSC cis rs34779708 0.733 rs16935945 chr10:35540320 A/C cg03585969 chr10:35415529 CREM 0.55 7.63 0.39 2.51e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg00677455 chr12:58241039 CTDSP2 0.7 10.53 0.5 1.45e-22 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg08499158 chr17:42289980 UBTF 0.41 6.34 0.33 7.43e-10 Total body bone mineral density; LUSC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg20476274 chr7:133979776 SLC35B4 0.88 17.02 0.68 3.21e-47 Mean platelet volume; LUSC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg03806693 chr22:41940476 POLR3H -0.88 -12.74 -0.57 1.45e-30 Vitiligo; LUSC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg24399712 chr22:39784796 NA -0.62 -11.12 -0.52 1.19e-24 Intelligence (multi-trait analysis); LUSC cis rs1322512 1.000 rs2758812 chr6:152965908 C/T cg27316956 chr6:152958899 SYNE1 -0.34 -6.05 -0.31 3.84e-9 Tonometry; LUSC cis rs11971779 0.584 rs7786469 chr7:139094621 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg18765753 chr7:1198926 ZFAND2A -0.59 -11.4 -0.53 1.15e-25 Longevity;Endometriosis; LUSC cis rs9372253 0.818 rs2207360 chr6:110706337 G/C cg00083206 chr6:110721305 DDO -0.45 -8.25 -0.41 3.77e-15 Platelet distribution width; LUSC cis rs9457247 0.624 rs9457260 chr6:167466665 C/T cg25258033 chr6:167368657 RNASET2 0.44 6.69 0.34 9.54e-11 Crohn's disease; LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg19318889 chr4:1322082 MAEA 0.48 7.88 0.4 4.54e-14 Obesity-related traits; LUSC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg18305652 chr10:134549665 INPP5A 0.46 6.83 0.35 4.01e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs12541635 0.966 rs56352125 chr8:107041831 G/T cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.72e-20 Age of smoking initiation; LUSC cis rs7590368 0.715 rs55770944 chr2:10959384 A/G cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg08392591 chr16:89556376 ANKRD11 0.44 6.65 0.34 1.19e-10 Multiple myeloma (IgH translocation); LUSC cis rs9325144 0.532 rs1352121 chr12:39130696 A/G cg13010199 chr12:38710504 ALG10B -0.47 -7.23 -0.37 3.3e-12 Morning vs. evening chronotype; LUSC cis rs9660992 0.710 rs55671824 chr1:205249814 G/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.34 -0.46 1.37e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg00825309 chr19:58991885 ZNF446 -0.52 -7.65 -0.39 2.1e-13 Uric acid clearance; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg08677398 chr8:58056175 NA 0.58 7.13 0.36 6.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.935 rs388394 chr6:145852689 C/T cg23711669 chr6:146136114 FBXO30 0.76 13.6 0.6 7.96e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs72781680 0.898 rs72780111 chr2:23991146 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs7829975 0.774 rs11775523 chr8:8679176 A/G cg15556689 chr8:8085844 FLJ10661 0.67 10.6 0.5 7.87e-23 Mood instability; LUSC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.83 -0.35 4.12e-11 Lung cancer; LUSC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg23093090 chr10:104574429 C10orf26 -0.37 -6.94 -0.35 2.06e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg09365446 chr1:150670422 GOLPH3L -0.52 -7.83 -0.39 6.7e-14 Urate levels; LUSC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg03433033 chr1:76189801 ACADM -0.83 -12.9 -0.58 3.66e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7647973 1.000 rs6446262 chr3:49401153 T/C cg07636037 chr3:49044803 WDR6 0.67 8.65 0.43 2.22e-16 Menarche (age at onset); LUSC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg15369054 chr17:80825471 TBCD 0.65 10.31 0.49 7.9e-22 Breast cancer; LUSC cis rs7589342 0.566 rs11895542 chr2:106390429 G/A cg09152813 chr2:106391379 NCK2 -0.38 -6.16 -0.32 2.12e-9 Addiction; LUSC cis rs3820068 0.608 rs12760450 chr1:16037282 G/A cg13390004 chr1:15929781 NA 0.42 6.86 0.35 3.29e-11 Systolic blood pressure; LUSC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg06558623 chr16:89946397 TCF25 1.11 9.73 0.47 7.08e-20 Skin colour saturation; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20002729 chr12:110318525 GLTP -0.44 -6.43 -0.33 4.44e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs11992162 0.967 rs7461062 chr8:11831948 T/C cg08975724 chr8:8085496 FLJ10661 0.52 7.24 0.37 3.2e-12 Monocyte count; LUSC cis rs919433 0.653 rs700651 chr2:198631714 G/A cg00792783 chr2:198669748 PLCL1 0.42 5.67 0.3 3.09e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs9399135 0.967 rs1023179 chr6:135343829 T/A cg22676075 chr6:135203613 NA 0.47 7.37 0.37 1.32e-12 Red blood cell count; LUSC cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg23711669 chr6:146136114 FBXO30 0.89 16.79 0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -7.73 -0.39 1.31e-13 Intelligence (multi-trait analysis); LUSC cis rs8031584 0.651 rs28664821 chr15:31172323 G/A cg14298792 chr15:30685198 CHRFAM7A 0.59 7.72 0.39 1.41e-13 Huntington's disease progression; LUSC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6542838 0.554 rs4311103 chr2:99538362 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.63 -0.34 1.32e-10 Fear of minor pain; LUSC cis rs1775715 0.737 rs2799012 chr10:32103077 C/T cg18675610 chr10:32216311 ARHGAP12 0.29 6.34 0.33 7.56e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1965732 1.000 rs6707320 chr2:3708966 A/G cg10645314 chr2:3704589 ALLC -0.38 -6.67 -0.34 1.04e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs6570726 0.905 rs1355146 chr6:145781741 A/C cg05347473 chr6:146136440 FBXO30 -0.38 -6.3 -0.33 9.2e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs6987853 0.712 rs56220385 chr8:42428862 A/T cg09913449 chr8:42400586 C8orf40 0.52 9.01 0.44 1.57e-17 Mean corpuscular hemoglobin concentration; LUSC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg09650180 chr20:62225654 GMEB2 -0.67 -9.59 -0.46 2.11e-19 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg12564285 chr5:131593104 PDLIM4 0.38 6.99 0.36 1.53e-11 Breast cancer; LUSC cis rs4474465 0.790 rs7481910 chr11:78264202 G/C cg27205649 chr11:78285834 NARS2 0.51 6.05 0.31 3.99e-9 Alzheimer's disease (survival time); LUSC cis rs2832077 1.000 rs2832077 chr21:30141021 G/A cg24692254 chr21:30365293 RNF160 -0.55 -6.74 -0.35 6.98e-11 Cognitive test performance; LUSC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg12463550 chr7:65579703 CRCP -0.52 -7.56 -0.38 3.83e-13 Aortic root size; LUSC cis rs55728055 0.661 rs62237765 chr22:31956981 A/G cg01338084 chr22:32026380 PISD 0.93 6.78 0.35 5.4e-11 Age-related hearing impairment; LUSC trans rs11098499 0.526 rs10026625 chr4:120280136 T/C cg25214090 chr10:38739885 LOC399744 0.4 6.31 0.33 8.77e-10 Corneal astigmatism; LUSC cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg18512352 chr11:47633146 NA -0.46 -9.31 -0.45 1.73e-18 Subjective well-being; LUSC cis rs2730245 0.527 rs2527197 chr7:158735260 G/A cg11984989 chr7:158649758 WDR60 -1.05 -12.11 -0.55 3.2e-28 Height; LUSC trans rs853679 0.546 rs13195291 chr6:28169241 G/A cg01620082 chr3:125678407 NA -0.85 -7.31 -0.37 1.99e-12 Depression; LUSC cis rs12931792 0.846 rs9924308 chr16:30154740 C/T cg17640201 chr16:30407289 ZNF48 -0.55 -8.91 -0.44 3.45e-17 Tonsillectomy; LUSC trans rs7647973 0.667 rs4241405 chr3:49642027 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 7e-13 Menarche (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26904215 chr21:47823096 PCNT -0.75 -6.05 -0.31 3.8e-9 Cognitive performance; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00929050 chr14:50359216 ARF6 0.47 6.73 0.35 7.39e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2587949 0.577 rs2629245 chr3:4236036 G/A cg15139668 chr4:4577005 NA 0.39 6.01 0.31 4.88e-9 Periodontitis (DPAL); LUSC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg10523679 chr1:76189770 ACADM -0.88 -14.16 -0.61 5.75e-36 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs8073060 0.504 rs225271 chr17:33969836 C/T cg19694781 chr19:47549865 TMEM160 -1.11 -17.38 -0.69 1.16e-48 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1467026 0.606 rs9814180 chr3:12818386 A/G cg24848339 chr3:12840334 CAND2 0.36 8.03 0.4 1.74e-14 P wave duration; LUSC cis rs738322 0.775 rs4820324 chr22:38599857 G/C cg17652424 chr22:38574118 PLA2G6 0.28 5.69 0.3 2.79e-8 Cutaneous nevi; LUSC cis rs113835537 0.529 rs4930183 chr11:66255732 C/T cg24851651 chr11:66362959 CCS 0.54 8.02 0.4 1.77e-14 Airway imaging phenotypes; LUSC cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.2 0.49 1.94e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2797160 1.000 rs1418951 chr6:125996185 A/G cg05901451 chr6:126070800 HEY2 -0.59 -8.83 -0.44 5.91e-17 Endometrial cancer; LUSC cis rs4077515 0.577 rs10870165 chr9:139316601 C/T cg14019695 chr9:139328340 INPP5E 0.49 9.38 0.46 1.06e-18 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs4862307 0.836 rs4507404 chr4:185003767 C/T cg06737308 chr4:185021514 ENPP6 -0.48 -7.52 -0.38 5.23e-13 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg18230493 chr5:56204884 C5orf35 -0.55 -8.85 -0.44 5.12e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg13010199 chr12:38710504 ALG10B 0.7 11.56 0.53 3.27e-26 Heart rate; LUSC cis rs1865760 1.000 rs9358895 chr6:25924655 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.82 0.35 4.38e-11 Height; LUSC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg16049864 chr8:95962084 TP53INP1 -0.63 -11.75 -0.54 6.52e-27 Type 2 diabetes; LUSC cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg09085632 chr11:111637200 PPP2R1B -1.08 -16.69 -0.67 6.84e-46 Primary sclerosing cholangitis; LUSC cis rs1371867 0.817 rs1788179 chr8:101333345 A/G cg06002616 chr8:101225028 SPAG1 -0.46 -7.47 -0.38 7.11e-13 Atrioventricular conduction; LUSC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg21028142 chr17:79581711 NPLOC4 -0.32 -7.81 -0.39 7.47e-14 Eye color traits; LUSC cis rs11997175 0.599 rs66474258 chr8:33640225 A/T ch.8.33884649F chr8:33765107 NA 0.53 8.56 0.42 4.33e-16 Body mass index; LUSC cis rs12545109 0.800 rs1553969 chr8:57420187 A/G cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC cis rs908922 0.676 rs6687126 chr1:152530894 T/G cg20991723 chr1:152506922 NA 0.49 9.21 0.45 3.74e-18 Hair morphology; LUSC cis rs2760061 0.599 rs849903 chr1:228137659 T/C cg04850211 chr1:228464232 OBSCN 0.32 5.67 0.3 3.08e-8 Diastolic blood pressure; LUSC cis rs2354432 0.607 rs894469 chr1:146672906 C/T cg25205988 chr1:146714368 CHD1L 1.05 8.62 0.43 2.81e-16 Mitochondrial DNA levels; LUSC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11644478 chr21:40555479 PSMG1 -0.87 -16.18 -0.66 7.13e-44 Cognitive function; LUSC cis rs7615316 0.807 rs7623524 chr3:142245984 A/T cg16271453 chr3:142027066 XRN1 -0.4 -6.83 -0.35 3.93e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs921968 0.565 rs2059717 chr2:219600316 A/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.4 -0.46 8.84e-19 Mean corpuscular hemoglobin concentration; LUSC cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.62 -0.34 1.44e-10 Monocyte percentage of white cells; LUSC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg15704280 chr7:45808275 SEPT13 -0.85 -14.29 -0.62 1.69e-36 Height; LUSC trans rs11700980 1.000 rs7283800 chr21:30107787 C/T cg05609335 chr17:75789393 NA -0.41 -6.55 -0.34 2.11e-10 QRS complex (12-leadsum); LUSC cis rs1799949 0.587 rs1824890 chr17:41421904 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 9.18 0.45 4.68e-18 Menopause (age at onset); LUSC trans rs9329221 0.662 rs12541491 chr8:10250048 C/T cg15556689 chr8:8085844 FLJ10661 0.63 8.84 0.44 5.45e-17 Neuroticism; LUSC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg02772935 chr3:125709198 NA -0.47 -6.1 -0.32 2.99e-9 Blood pressure (smoking interaction); LUSC cis rs6688613 0.729 rs7545806 chr1:166938555 T/C cg07049167 chr1:166818506 POGK 0.43 5.77 0.3 1.79e-8 Refractive astigmatism; LUSC trans rs877282 0.898 rs11253340 chr10:764786 G/T cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs2658782 0.789 rs3020076 chr11:93141058 C/T cg15737290 chr11:93063684 CCDC67 0.64 7.97 0.4 2.62e-14 Pulmonary function decline; LUSC cis rs7084921 0.578 rs11190393 chr10:101869988 C/T cg11888571 chr10:102027403 CWF19L1 -0.42 -5.73 -0.3 2.3e-8 Bone mineral density; LUSC trans rs61931739 0.817 rs10743842 chr12:34306859 C/T cg26384229 chr12:38710491 ALG10B 0.56 9.1 0.45 8.21e-18 Morning vs. evening chronotype; LUSC cis rs7937682 0.924 rs875258 chr11:111530607 C/A cg19812747 chr11:111475976 SIK2 -0.48 -6.84 -0.35 3.87e-11 Primary sclerosing cholangitis; LUSC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg01879757 chr17:41196368 BRCA1 -0.46 -7.0 -0.36 1.44e-11 Menopause (age at onset); LUSC cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.12 -0.36 6.54e-12 Menopause (age at onset); LUSC cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg23711669 chr6:146136114 FBXO30 0.88 16.36 0.67 1.35e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs28493229 0.786 rs73546894 chr19:41189203 C/T cg21869046 chr19:41225005 ITPKC 0.57 7.5 0.38 5.85e-13 Kawasaki disease; LUSC cis rs7215564 0.818 rs112155856 chr17:78594573 A/T cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.21e-9 Myopia (pathological); LUSC cis rs59698941 0.943 rs60042606 chr5:132248170 G/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -7.48 -0.38 6.55e-13 Chronic sinus infection; LUSC cis rs897984 0.542 rs750952 chr16:31093954 C/T cg02466173 chr16:30829666 NA -0.51 -9.48 -0.46 4.85e-19 Dementia with Lewy bodies; LUSC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg25456477 chr12:86230367 RASSF9 0.37 6.43 0.33 4.34e-10 Major depressive disorder; LUSC cis rs2742417 1.000 rs2673057 chr3:45735730 A/T cg09608765 chr3:45636137 LIMD1 -0.35 -6.94 -0.36 2.05e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs6961069 0.837 rs1761662 chr7:80238463 C/T cg04458919 chr7:80252533 CD36 -0.37 -6.76 -0.35 6.03e-11 Platelet count; LUSC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.08 -0.32 3.31e-9 Developmental language disorder (linguistic errors); LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg19747945 chr6:42946146 PEX6 -0.35 -5.85 -0.3 1.16e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg27572855 chr1:25598939 RHD 0.41 7.23 0.37 3.22e-12 Erythrocyte sedimentation rate; LUSC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg04455712 chr21:45112962 RRP1B 0.5 9.6 0.47 1.92e-19 Mean corpuscular volume; LUSC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg05552183 chr6:42928497 GNMT 0.48 8.07 0.4 1.3e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3768617 0.706 rs8179460 chr1:183056222 T/C ch.1.3577855R chr1:183094577 LAMC1 0.6 8.57 0.42 3.79e-16 Fuchs's corneal dystrophy; LUSC cis rs3755132 0.929 rs16862823 chr2:15775210 T/C cg12888861 chr2:15731646 DDX1 0.52 7.43 0.38 9.29e-13 Wilms tumor; LUSC cis rs782590 0.934 rs62165184 chr2:55788253 G/C cg03859395 chr2:55845619 SMEK2 0.88 16.19 0.66 6.22e-44 Metabolic syndrome; LUSC cis rs2063714 0.532 rs2063713 chr6:157196299 G/T cg23222435 chr6:157204239 ARID1B -0.71 -11.91 -0.55 1.62e-27 Sitting height ratio; LUSC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg06636001 chr8:8085503 FLJ10661 0.65 10.78 0.51 1.96e-23 Mood instability; LUSC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.47 -7.07 -0.36 9.37e-12 Alzheimer's disease (late onset); LUSC cis rs10089 0.953 rs6875982 chr5:127529197 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.83 11.45 0.53 7.93e-26 Ileal carcinoids; LUSC cis rs7605827 0.930 rs6740183 chr2:15692583 T/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs240764 0.658 rs9390679 chr6:101216102 C/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.26 -0.32 1.21e-9 Neuroticism; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg00431813 chr7:1051703 C7orf50 -0.42 -6.62 -0.34 1.42e-10 Longevity;Endometriosis; LUSC cis rs2463822 1.000 rs2513747 chr11:62098735 T/C cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs9291683 0.588 rs17247314 chr4:10004743 C/G cg26043149 chr18:55253948 FECH 0.49 7.05 0.36 1.05e-11 Bone mineral density; LUSC trans rs11088226 0.681 rs2833903 chr21:33940819 C/T cg09050820 chr6:167586206 TCP10L2 0.74 9.61 0.47 1.89e-19 Gastritis; LUSC trans rs372883 0.600 rs2832293 chr21:30738872 C/G cg14791747 chr16:20752902 THUMPD1 -0.42 -6.12 -0.32 2.67e-9 Pancreatic cancer; LUSC trans rs11098499 0.908 rs28499576 chr4:120386677 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.23 0.41 4.16e-15 Corneal astigmatism; LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.77 0.43 9.36e-17 Alzheimer's disease; LUSC cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg13256891 chr4:100009986 ADH5 0.48 7.08 0.36 8.67e-12 Alcohol dependence; LUSC cis rs11229555 0.645 rs12785578 chr11:58206432 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6546886 0.912 rs4331526 chr2:74294449 A/C cg14702570 chr2:74259524 NA -0.3 -5.73 -0.3 2.26e-8 Dialysis-related mortality; LUSC cis rs79349575 0.716 rs46522 chr17:46988597 C/T cg22482690 chr17:47019901 SNF8 0.32 5.74 0.3 2.09e-8 Type 2 diabetes; LUSC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg26695010 chr11:65641043 EFEMP2 -0.46 -7.01 -0.36 1.32e-11 Eosinophil percentage of white cells; LUSC cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg23583168 chr7:148888333 NA -0.78 -13.43 -0.59 3.56e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7000551 0.680 rs28546543 chr8:22314872 A/C cg12081754 chr8:22256438 SLC39A14 0.46 6.99 0.36 1.46e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg11663144 chr21:46675770 NA -0.32 -5.67 -0.3 3.04e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg09655341 chr17:79618100 PDE6G -0.29 -6.64 -0.34 1.29e-10 Eye color traits; LUSC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg00310523 chr12:86230176 RASSF9 0.53 10.0 0.48 9.39e-21 Major depressive disorder; LUSC cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg21573476 chr21:45109991 RRP1B -0.38 -6.22 -0.32 1.47e-9 Mean corpuscular volume; LUSC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -7.06 -0.36 9.99e-12 Major depressive disorder; LUSC cis rs17401966 0.522 rs12133617 chr1:10288463 C/T cg19773385 chr1:10388646 KIF1B -0.36 -6.13 -0.32 2.51e-9 Hepatocellular carcinoma; LUSC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg25456477 chr12:86230367 RASSF9 -0.44 -7.97 -0.4 2.57e-14 Major depressive disorder; LUSC cis rs6089584 0.566 rs55881457 chr20:60608424 G/A cg06108461 chr20:60628389 TAF4 -0.74 -11.98 -0.55 9.08e-28 Body mass index; LUSC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg14949292 chr17:78079608 GAA -0.3 -5.74 -0.3 2.15e-8 Yeast infection; LUSC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg13114125 chr14:105738426 BRF1 -0.92 -15.61 -0.65 1.22e-41 Mean platelet volume;Platelet distribution width; LUSC trans rs57046232 0.552 rs6139968 chr20:6319606 A/C cg17788362 chr6:86352627 SYNCRIP 0.45 6.23 0.32 1.38e-9 Colorectal cancer; LUSC trans rs6952808 0.692 rs11773316 chr7:2027354 C/T cg04565464 chr8:145669602 NFKBIL2 0.39 6.41 0.33 4.84e-10 Bipolar disorder and schizophrenia; LUSC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.78 0.47 4.89e-20 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs208520 1.000 rs208523 chr6:66954195 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -12.34 -0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs7666738 0.579 rs7672718 chr4:98645122 A/G cg03676636 chr4:99064102 C4orf37 0.3 5.96 0.31 6.35e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2795502 1.000 rs2795496 chr10:43337842 G/A cg27426351 chr10:43362370 NA -0.43 -5.99 -0.31 5.54e-9 Blood protein levels; LUSC cis rs9473147 0.543 rs9381578 chr6:47556634 C/T cg02130027 chr6:47444894 CD2AP 0.35 5.7 0.3 2.68e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg13390004 chr1:15929781 NA 0.42 6.9 0.35 2.55e-11 Systolic blood pressure; LUSC cis rs1577917 1.000 rs35760725 chr6:86648985 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.69e-9 Response to antipsychotic treatment; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26297968 chr2:211035960 C2orf67 0.45 7.23 0.37 3.28e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg26818010 chr10:134567672 INPP5A -0.83 -10.57 -0.5 1.04e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs500891 0.525 rs2875343 chr6:84101327 G/C cg08257003 chr6:84140564 ME1 0.33 8.05 0.4 1.46e-14 Platelet-derived growth factor BB levels; LUSC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.68e-10 Depression; LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.15 -0.49 2.92e-21 Platelet count; LUSC cis rs644799 0.687 rs11021318 chr11:95522996 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.87 13.55 0.6 1.18e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs67478160 0.608 rs4906368 chr14:104242397 A/C cg01849466 chr14:104193079 ZFYVE21 -0.61 -10.33 -0.49 6.65e-22 Schizophrenia; LUSC cis rs1160297 0.609 rs12618983 chr2:53091691 C/T cg07782112 chr2:53107842 NA -0.4 -6.43 -0.33 4.51e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs10746514 1.000 rs1576618 chr1:232244331 A/G cg09506761 chr1:232265262 NA -0.43 -7.05 -0.36 1.01e-11 Response to statin therapy; LUSC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg03517284 chr6:25882590 NA -0.4 -7.01 -0.36 1.35e-11 Height; LUSC cis rs10791097 0.703 rs11222360 chr11:130730871 C/T cg12179176 chr11:130786555 SNX19 0.74 12.09 0.55 3.67e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg17294928 chr15:75287854 SCAMP5 0.82 10.82 0.51 1.36e-23 Blood trace element (Zn levels); LUSC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg27532560 chr4:187881888 NA -0.39 -6.41 -0.33 5.1e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 7.33 0.37 1.77e-12 Cerebrospinal P-tau181p levels; LUSC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg15448220 chr1:150897856 SETDB1 0.43 6.1 0.32 2.86e-9 Melanoma; LUSC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg15744005 chr10:104629667 AS3MT -0.29 -6.28 -0.32 1.05e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg21280719 chr6:42927975 GNMT -0.3 -7.27 -0.37 2.49e-12 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs208520 0.690 rs207107 chr6:66794385 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC cis rs6542838 0.641 rs12478574 chr2:99476369 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.02 -0.31 4.5e-9 Fear of minor pain; LUSC cis rs8114671 0.935 rs6060282 chr20:33767066 C/T cg24642439 chr20:33292090 TP53INP2 0.4 5.84 0.3 1.22e-8 Height; LUSC cis rs2840044 1.000 rs11653310 chr17:33893378 C/G cg05299278 chr17:33885742 SLFN14 0.28 5.95 0.31 6.84e-9 Response to radiotherapy in cancer (late toxicity); LUSC trans rs8073060 0.586 rs225292 chr17:33926383 G/A cg19694781 chr19:47549865 TMEM160 -1.04 -16.14 -0.66 1.05e-43 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 13.98 0.61 2.73e-35 Platelet count; LUSC cis rs6752107 1.000 rs6752107 chr2:234161448 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.71 11.98 0.55 9.48e-28 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.14e-21 Bladder cancer; LUSC cis rs4903604 0.581 rs11850485 chr14:78033863 A/G cg18872420 chr14:78023429 SPTLC2 0.4 6.06 0.31 3.75e-9 Gut microbiome composition (winter); LUSC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg19077165 chr18:44547161 KATNAL2 -0.41 -6.14 -0.32 2.3e-9 Personality dimensions; LUSC cis rs11642862 1.000 rs111954099 chr16:30789623 A/G cg02466173 chr16:30829666 NA -0.66 -7.14 -0.36 5.79e-12 Tonsillectomy; LUSC cis rs9638182 0.522 rs61010704 chr7:73019975 A/G cg07452164 chr7:72993570 TBL2 0.47 6.45 0.33 3.86e-10 Triglycerides; LUSC cis rs2625529 0.824 rs7183749 chr15:72377278 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.63 -0.39 2.45e-13 Red blood cell count; LUSC cis rs2404602 0.647 rs1443115 chr15:77041829 T/C cg23625390 chr15:77176239 SCAPER -0.66 -10.01 -0.48 8.54e-21 Blood metabolite levels; LUSC cis rs7180079 1.000 rs62021599 chr15:64535177 G/A cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg05340658 chr4:99064831 C4orf37 0.64 10.99 0.52 3.39e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg11663144 chr21:46675770 NA -0.4 -6.86 -0.35 3.36e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11792861 0.525 rs2417975 chr9:111860185 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 6.86 0.35 3.32e-11 Menarche (age at onset); LUSC cis rs4444235 0.564 rs9323252 chr14:54404121 G/A cg16720578 chr14:54410717 NA 0.36 6.82 0.35 4.39e-11 Colorectal cancer; LUSC cis rs4478858 0.735 rs12134484 chr1:31823741 G/A cg00250761 chr1:31883323 NA -0.35 -8.66 -0.43 1.99e-16 Alcohol dependence; LUSC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg01657329 chr11:68192670 LRP5 -0.47 -7.59 -0.38 3.12e-13 Total body bone mineral density; LUSC cis rs6754459 1.000 rs6754459 chr2:3707423 C/T cg00999904 chr2:3704751 ALLC -0.41 -7.14 -0.36 5.82e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.54 -9.36 -0.46 1.23e-18 Bipolar disorder; LUSC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.62 9.16 0.45 5.44e-18 Squamous cell carcinoma; LUSC cis rs7904368 0.754 rs12253908 chr10:16853358 T/C cg23933602 chr10:16859644 RSU1 0.58 6.79 0.35 4.99e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs7249142 0.549 rs72997174 chr19:19294389 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 9.35 0.46 1.28e-18 IgG glycosylation; LUSC cis rs7208859 0.623 rs77009951 chr17:29080650 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2298450 0.512 rs2245474 chr21:37612407 C/G cg02919814 chr21:37666008 DOPEY2 0.42 6.31 0.33 8.96e-10 Schizophrenia; LUSC trans rs2797160 1.000 rs9401843 chr6:126004124 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.74 -0.35 6.9e-11 Endometrial cancer; LUSC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.31 0.45 1.75e-18 Total body bone mineral density; LUSC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 10.81 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg07777115 chr5:623756 CEP72 -0.47 -5.96 -0.31 6.52e-9 Obesity-related traits; LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg13206674 chr6:150067644 NUP43 0.59 9.47 0.46 5.14e-19 Lung cancer; LUSC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg04369109 chr6:150039330 LATS1 -0.58 -8.43 -0.42 1.02e-15 Lung cancer; LUSC cis rs7149337 0.869 rs7159770 chr14:51691835 G/A cg23942311 chr14:51606299 NA 0.48 10.51 0.5 1.58e-22 Cancer; LUSC cis rs6964587 1.000 rs1859114 chr7:91682848 T/C cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg17294928 chr15:75287854 SCAMP5 -0.84 -11.42 -0.53 1.01e-25 Blood trace element (Zn levels); LUSC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg07701084 chr6:150067640 NUP43 0.48 6.74 0.35 7.17e-11 Lung cancer; LUSC cis rs7605827 0.930 rs1019358 chr2:15524042 A/G cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg04166393 chr7:2884313 GNA12 0.45 5.87 0.31 1.05e-8 Height; LUSC cis rs6840360 0.615 rs12641438 chr4:152607586 A/G cg22705602 chr4:152727874 NA -0.37 -7.93 -0.4 3.32e-14 Intelligence (multi-trait analysis); LUSC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.86 0.4 5.17e-14 Parkinson's disease; LUSC cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg14582100 chr15:45693742 SPATA5L1 0.59 10.78 0.51 1.84e-23 Homoarginine levels; LUSC cis rs4253772 0.872 rs45576734 chr22:46638365 A/G cg18190219 chr22:46762943 CELSR1 -0.48 -5.81 -0.3 1.45e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs7824557 0.767 rs2060463 chr8:11161610 T/G cg27411982 chr8:10470053 RP1L1 0.37 5.86 0.31 1.13e-8 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg07636037 chr3:49044803 WDR6 1.05 19.08 0.72 1.98e-55 Parkinson's disease; LUSC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg16447950 chr5:562315 NA -0.57 -7.18 -0.37 4.58e-12 Lung disease severity in cystic fibrosis; LUSC cis rs1865760 0.892 rs6456705 chr6:25936056 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 7.0 0.36 1.44e-11 Height; LUSC cis rs854765 0.547 rs2955377 chr17:17932818 G/A cg24904631 chr17:17875305 TOM1L2;LRRC48 0.37 5.85 0.3 1.18e-8 Total body bone mineral density; LUSC cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg11266682 chr4:10021025 SLC2A9 0.55 9.89 0.48 2.07e-20 Bone mineral density; LUSC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg06008330 chr7:65541103 ASL 0.4 6.17 0.32 1.96e-9 Aortic root size; LUSC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.77 9.92 0.48 1.68e-20 Gut microbiome composition (summer); LUSC cis rs4253772 0.530 rs9615933 chr22:46677298 G/A cg09491104 chr22:46646882 C22orf40 -0.68 -6.76 -0.35 6.1e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs593982 1.000 rs74638829 chr11:65495571 C/T cg08755490 chr11:65554678 OVOL1 -1.45 -15.28 -0.64 2.39e-40 Atopic dermatitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25539011 chr4:139936823 CCRN4L -0.41 -6.07 -0.32 3.38e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9905704 0.647 rs9901655 chr17:56987142 G/A cg05425664 chr17:57184151 TRIM37 -0.45 -6.76 -0.35 6.2e-11 Testicular germ cell tumor; LUSC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg23630131 chr7:65973040 NA 0.21 5.88 0.31 9.83e-9 Aortic root size; LUSC trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs4629710 0.592 rs11154622 chr6:131547578 C/T cg12606694 chr6:131520996 AKAP7 0.62 9.44 0.46 6.45e-19 Multiple myeloma (IgH translocation); LUSC trans rs61931739 0.500 rs11053177 chr12:34412829 G/A cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.35e-33 Morning vs. evening chronotype; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg05313129 chr8:58192883 C8orf71 -0.51 -5.99 -0.31 5.57e-9 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.955 rs5770750 chr22:50276828 A/G cg08270630 chr22:50330655 NA 0.41 6.05 0.31 3.98e-9 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26547359 chr10:16859530 RSU1 -0.51 -6.5 -0.34 2.99e-10 Bipolar disorder and schizophrenia; LUSC cis rs4919087 0.590 rs2861877 chr10:99053316 C/A cg25902810 chr10:99078978 FRAT1 -0.42 -5.73 -0.3 2.3e-8 Monocyte count; LUSC cis rs12541635 0.967 rs11997513 chr8:107093325 C/T cg10147462 chr8:107024639 NA -0.49 -8.99 -0.44 1.89e-17 Age of smoking initiation; LUSC cis rs11630290 0.592 rs12232261 chr15:64153302 A/G cg12036633 chr15:63758958 NA 0.52 6.67 0.34 1.05e-10 Iris characteristics; LUSC cis rs981844 0.712 rs4434231 chr4:154746293 G/T cg14289246 chr4:154710475 SFRP2 -0.49 -6.61 -0.34 1.52e-10 Response to statins (LDL cholesterol change); LUSC cis rs4704187 0.687 rs4404660 chr5:74422210 T/C cg03227963 chr5:74354835 NA 0.32 6.9 0.35 2.6e-11 Response to amphetamines; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20994686 chr17:71306668 CDC42EP4 0.49 7.44 0.38 8.33e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg08270630 chr22:50330655 NA 0.41 6.06 0.31 3.64e-9 Schizophrenia; LUSC cis rs3791556 0.501 rs3791536 chr2:240101713 G/A cg03281426 chr2:240109471 HDAC4 0.43 6.21 0.32 1.58e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg17366294 chr4:99064904 C4orf37 -0.56 -9.59 -0.46 2.07e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.2 0.37 4.13e-12 Cognitive ability; LUSC cis rs4363385 0.818 rs11205174 chr1:153001230 C/T cg25856811 chr1:152973957 SPRR3 0.35 5.86 0.31 1.12e-8 Inflammatory skin disease; LUSC cis rs6460942 0.908 rs967126 chr7:12237300 G/C cg06484146 chr7:12443880 VWDE -0.59 -6.17 -0.32 1.94e-9 Coronary artery disease; LUSC cis rs317865 0.609 rs73234660 chr4:16221047 G/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.61 5.94 0.31 7.13e-9 Kidney disease (early stage) in type 1 diabetes; LUSC cis rs1775715 0.737 rs2799031 chr10:32173168 C/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.56 0.34 2.04e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs13418410 0.715 rs4670209 chr2:33802956 G/A cg04131969 chr2:33951647 MYADML -0.45 -5.95 -0.31 6.64e-9 Non-response to antidepressants and depression; LUSC cis rs9359856 0.564 rs1036853 chr6:90499502 G/A cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.17 -0.41 6.64e-15 Bipolar disorder; LUSC cis rs926392 0.589 rs2019032 chr20:37680326 C/A cg16355469 chr20:37678765 NA 0.53 7.16 0.36 5.21e-12 Dialysis-related mortality; LUSC cis rs10489202 1.000 rs2272911 chr1:167936302 C/T cg24449463 chr1:168025552 DCAF6 -0.58 -7.37 -0.37 1.32e-12 Schizophrenia; LUSC cis rs35146811 0.735 rs1727139 chr7:99815367 C/T cg13334819 chr7:99746414 C7orf59 0.5 6.76 0.35 6.07e-11 Coronary artery disease; LUSC cis rs1371867 0.846 rs2439458 chr8:101297984 T/C cg06636551 chr8:101224915 SPAG1 -0.4 -7.41 -0.38 1.06e-12 Atrioventricular conduction; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg02951883 chr7:2050386 MAD1L1 -0.63 -12.32 -0.56 5.32e-29 Bipolar disorder and schizophrenia; LUSC cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg08330031 chr10:104623503 C10orf32 0.32 5.7 0.3 2.61e-8 Arsenic metabolism; LUSC cis rs11122272 0.735 rs2790891 chr1:231513190 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg01341218 chr17:43662625 NA -0.76 -11.1 -0.52 1.45e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg16145915 chr7:1198662 ZFAND2A -0.48 -8.61 -0.43 3.01e-16 Longevity;Endometriosis; LUSC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg13607699 chr17:42295918 UBTF 0.61 10.3 0.49 8.56e-22 Total body bone mineral density; LUSC cis rs17685 0.753 rs4728586 chr7:75802869 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.32 -0.37 1.9e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.56 0.5 1.11e-22 Homoarginine levels; LUSC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg03233332 chr7:66118400 NA -0.43 -6.21 -0.32 1.6e-9 Aortic root size; LUSC cis rs4713675 0.584 rs7739505 chr6:33670370 G/A cg14003231 chr6:33640908 ITPR3 0.31 5.97 0.31 5.95e-9 Plateletcrit; LUSC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg02807482 chr3:125708958 NA -0.52 -6.5 -0.33 2.98e-10 Blood pressure (smoking interaction); LUSC cis rs929354 0.742 rs7801905 chr7:156940111 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg04315214 chr1:2043799 PRKCZ 0.47 9.92 0.48 1.65e-20 Height; LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg27170947 chr2:26402098 FAM59B -0.69 -10.54 -0.5 1.32e-22 Gut microbiome composition (summer); LUSC cis rs1348850 0.914 rs2364854 chr2:178378452 T/A cg22681709 chr2:178499509 PDE11A -0.51 -9.49 -0.46 4.7e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7954584 0.523 rs11043280 chr12:122426643 T/C cg10207240 chr12:122356781 WDR66 0.44 6.31 0.33 8.64e-10 Mean corpuscular volume; LUSC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg17211192 chr8:82754475 SNX16 -0.64 -9.11 -0.45 7.56e-18 Diastolic blood pressure; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18295930 chr20:46130624 NCOA3 -0.48 -7.05 -0.36 1.04e-11 Electrocardiographic conduction measures; LUSC cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg23158103 chr7:148848205 ZNF398 -0.49 -8.01 -0.4 1.98e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs17253792 0.822 rs76612185 chr14:56037706 T/C cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg05368731 chr17:41323189 NBR1 0.93 15.69 0.65 5.75e-42 Menopause (age at onset); LUSC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg06221963 chr1:154839813 KCNN3 0.66 16.08 0.66 1.74e-43 Prostate cancer; LUSC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg04369109 chr6:150039330 LATS1 -0.56 -8.25 -0.41 3.74e-15 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19628164 chr3:143689916 C3orf58 -0.54 -7.16 -0.36 5.21e-12 Bipolar disorder and schizophrenia; LUSC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg05738196 chr6:26577821 NA 0.52 8.3 0.41 2.53e-15 Schizophrenia; LUSC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg00784671 chr22:46762841 CELSR1 -0.56 -6.87 -0.35 3.09e-11 LDL cholesterol;Cholesterol, total; LUSC trans rs8073060 0.586 rs4796104 chr17:34046832 T/C cg19694781 chr19:47549865 TMEM160 1.14 18.04 0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg19678392 chr7:94953810 PON1 -0.36 -5.65 -0.3 3.47e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs7615952 0.641 rs12488180 chr3:125782236 C/T cg07211511 chr3:129823064 LOC729375 -0.76 -10.11 -0.48 3.98e-21 Blood pressure (smoking interaction); LUSC cis rs9309473 1.000 rs6705489 chr2:73648811 G/T cg20560298 chr2:73613845 ALMS1 -0.43 -6.16 -0.32 2.03e-9 Metabolite levels; LUSC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg24642844 chr7:1081250 C7orf50 -0.5 -7.99 -0.4 2.26e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs599083 0.829 rs23691 chr11:68178668 G/A cg20283391 chr11:68216788 NA 0.5 6.78 0.35 5.4e-11 Bone mineral density (spine); LUSC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg01879757 chr17:41196368 BRCA1 -0.4 -6.08 -0.32 3.23e-9 Menopause (age at onset); LUSC cis rs243505 0.559 rs10215159 chr7:148479071 G/C cg09806900 chr7:148480153 CUL1 0.68 10.09 0.48 4.52e-21 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg15468180 chr1:107600409 PRMT6 -0.4 -6.38 -0.33 5.78e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs4808199 1.000 rs17288409 chr19:19504167 T/C cg03709012 chr19:19516395 GATAD2A 1.11 14.4 0.62 6.72e-37 Nonalcoholic fatty liver disease; LUSC cis rs9311676 0.656 rs11917591 chr3:58368449 C/T cg13750441 chr3:58318267 PXK -0.33 -6.59 -0.34 1.74e-10 Systemic lupus erythematosus; LUSC cis rs78579285 0.583 rs77376965 chr16:88800477 G/A cg01900006 chr16:88814613 FAM38A 0.61 6.77 0.35 5.7e-11 Joint mobility (Beighton score); LUSC cis rs9287719 0.967 rs4453662 chr2:10739128 G/A cg00105475 chr2:10696890 NA 0.38 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg05084668 chr3:125655381 ALG1L -0.49 -6.86 -0.35 3.34e-11 Blood pressure (smoking interaction); LUSC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg03929089 chr4:120376271 NA -1.03 -20.11 -0.74 1.74e-59 Height; LUSC cis rs10744422 0.920 rs897393 chr12:123312051 A/G cg25930673 chr12:123319894 HIP1R 0.6 6.2 0.32 1.65e-9 Schizophrenia; LUSC cis rs10197940 0.578 rs2432957 chr2:152287897 A/C cg06191203 chr2:152266755 RIF1 -0.43 -5.91 -0.31 8.53e-9 Lung cancer; LUSC cis rs7923609 0.846 rs7075901 chr10:65280994 C/A cg01631684 chr10:65280961 REEP3 -0.41 -6.39 -0.33 5.66e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs12472274 0.617 rs7568705 chr2:239081808 C/T cg17459225 chr2:239074497 NA 0.52 8.62 0.43 2.72e-16 Phospholipid levels (plasma); LUSC cis rs2991971 1.000 rs606542 chr1:46013933 T/C cg15605315 chr1:45957053 TESK2 0.46 7.19 0.37 4.38e-12 High light scatter reticulocyte count; LUSC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg25072359 chr17:41440525 NA 0.6 8.64 0.43 2.33e-16 Menopause (age at onset); LUSC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11644478 chr21:40555479 PSMG1 -0.88 -16.8 -0.68 2.41e-46 Cognitive function; LUSC cis rs2677744 0.626 rs3743452 chr15:91497515 C/T cg23684204 chr15:91497937 RCCD1 -0.6 -8.44 -0.42 9.54e-16 Attention deficit hyperactivity disorder; LUSC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg24250549 chr1:154909240 PMVK 0.64 10.43 0.5 3.19e-22 Prostate cancer; LUSC cis rs17253792 0.822 rs113350960 chr14:56087713 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC trans rs11098499 0.818 rs7688802 chr4:120451668 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg11062466 chr8:58055876 NA 0.5 6.32 0.33 8.39e-10 Developmental language disorder (linguistic errors); LUSC cis rs7824557 0.579 rs10098322 chr8:11196295 C/G cg21775007 chr8:11205619 TDH 0.74 12.67 0.57 2.71e-30 Retinal vascular caliber; LUSC cis rs597583 0.806 rs11603366 chr11:117396505 G/T cg27161313 chr11:117392002 DSCAML1 -0.43 -7.19 -0.37 4.33e-12 Putamen volume; LUSC cis rs920590 0.643 rs13280085 chr8:19669959 G/T cg03894339 chr8:19674705 INTS10 -0.43 -6.28 -0.32 1.05e-9 Acute lymphoblastic leukemia (childhood); LUSC trans rs61931739 0.500 rs7306435 chr12:34482933 A/G cg26384229 chr12:38710491 ALG10B -0.9 -15.62 -0.65 1.1e-41 Morning vs. evening chronotype; LUSC cis rs6539267 0.741 rs10861572 chr12:106688576 A/G cg00173435 chr12:106696525 TCP11L2 -0.61 -8.97 -0.44 2.1e-17 Tourette syndrome; LUSC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg02487422 chr3:49467188 NICN1 0.44 7.09 0.36 7.95e-12 Resting heart rate; LUSC trans rs931812 0.895 rs965625 chr8:101909749 T/C cg20993868 chr7:22813445 NA 0.64 11.75 0.54 6.73e-27 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg25282410 chr6:160211355 TCP1;MRPL18 1.11 16.49 0.67 4.22e-45 Age-related macular degeneration (geographic atrophy); LUSC cis rs4629710 0.592 rs13206776 chr6:131576679 T/G cg12606694 chr6:131520996 AKAP7 0.62 9.46 0.46 5.64e-19 Multiple myeloma (IgH translocation); LUSC cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg15073853 chr19:18549131 ISYNA1 -0.33 -5.92 -0.31 8.14e-9 Breast cancer; LUSC cis rs4919694 1.000 rs3740394 chr10:104634474 A/G cg23093090 chr10:104574429 C10orf26 -0.49 -5.86 -0.31 1.12e-8 Arsenic metabolism; LUSC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg11764359 chr7:65958608 NA 0.49 6.09 0.32 3.19e-9 Aortic root size; LUSC cis rs7246967 0.673 rs2361023 chr19:22816867 C/T cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13732083 chr21:47605072 C21orf56 0.43 6.25 0.32 1.27e-9 Testicular germ cell tumor; LUSC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg21880101 chr17:80066754 CCDC57 -0.31 -5.91 -0.31 8.41e-9 Life satisfaction; LUSC cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 12.82 0.57 7.03e-31 Chronic sinus infection; LUSC cis rs7267979 0.932 rs6107052 chr20:25530838 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.28 0.71 3.22e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6690583 0.623 rs12033900 chr1:85478559 T/C cg11262906 chr1:85462892 MCOLN2 0.67 6.34 0.33 7.32e-10 Serum sulfate level; LUSC cis rs727505 0.866 rs17327181 chr7:124720303 A/G cg23710748 chr7:124431027 NA -0.38 -6.71 -0.34 8.35e-11 Lewy body disease; LUSC cis rs55665837 1.000 rs12295723 chr11:14450201 T/C cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg06484146 chr7:12443880 VWDE -0.75 -7.52 -0.38 4.97e-13 Coronary artery disease; LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg16606324 chr3:10149918 C3orf24 0.6 8.66 0.43 2.03e-16 Alzheimer's disease; LUSC cis rs7584330 0.518 rs7585969 chr2:238439073 G/A cg16989719 chr2:238392110 NA -0.5 -6.41 -0.33 4.87e-10 Prostate cancer; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg16274148 chr9:100684771 C9orf156 0.54 6.71 0.34 8.14e-11 Cognitive function;Information processing speed; LUSC cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg08807101 chr21:30365312 RNF160 -0.76 -13.45 -0.59 2.85e-33 Dental caries; LUSC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg27129171 chr3:47204927 SETD2 0.73 12.77 0.57 1.1e-30 Colorectal cancer; LUSC cis rs2859741 0.546 rs10489413 chr1:37513906 C/T cg09363841 chr1:37513479 NA -0.37 -7.3 -0.37 2.13e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs7567389 0.600 rs7590030 chr2:128055967 G/A cg09760422 chr2:128146352 NA -0.28 -5.66 -0.3 3.28e-8 Self-rated health; LUSC trans rs62458065 0.850 rs10239812 chr7:32460348 A/G cg00845942 chr12:64062724 DPY19L2 -0.54 -6.09 -0.32 3.14e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg25427524 chr10:38739819 LOC399744 0.63 11.23 0.52 4.99e-25 Extrinsic epigenetic age acceleration; LUSC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg12463550 chr7:65579703 CRCP -0.42 -6.04 -0.31 4.22e-9 Calcium levels; LUSC cis rs9303401 0.659 rs35564417 chr17:56718286 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.55e-35 Cognitive test performance; LUSC cis rs4727027 0.704 rs10952805 chr7:148907849 G/A cg14690467 chr7:148917905 ZNF282 -0.26 -5.69 -0.3 2.82e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7592578 0.713 rs60915953 chr2:191331304 G/C cg11845111 chr2:191398756 TMEM194B -0.87 -10.5 -0.5 1.79e-22 Diastolic blood pressure; LUSC cis rs12908161 1.000 rs62019469 chr15:85321220 T/C cg17507749 chr15:85114479 UBE2QP1 0.53 6.58 0.34 1.87e-10 Schizophrenia; LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22557350 chr10:126432983 FAM53B -0.42 -6.2 -0.32 1.64e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg09877947 chr5:131593287 PDLIM4 0.42 6.98 0.36 1.57e-11 Blood metabolite levels; LUSC cis rs8141529 0.764 rs8137969 chr22:29228484 G/C cg15103426 chr22:29168792 CCDC117 0.59 8.32 0.41 2.28e-15 Lymphocyte counts; LUSC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg03806693 chr22:41940476 POLR3H 0.91 12.91 0.58 3.36e-31 Vitiligo; LUSC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg20135002 chr11:47629003 NA -0.51 -7.92 -0.4 3.59e-14 Subjective well-being; LUSC cis rs7178572 0.849 rs12901503 chr15:77819056 A/G cg22256960 chr15:77711686 NA -0.52 -8.47 -0.42 8.1e-16 Type 2 diabetes; LUSC cis rs911119 0.909 rs111360484 chr20:23618984 G/C cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC cis rs7809950 0.678 rs7788330 chr7:106985648 G/T cg23024343 chr7:107201750 COG5 -0.66 -9.9 -0.48 1.99e-20 Coronary artery disease; LUSC cis rs6599077 0.950 rs4676561 chr3:40101286 G/T cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs597583 0.760 rs688968 chr11:117406739 C/G cg27161313 chr11:117392002 DSCAML1 -0.49 -7.65 -0.39 2.14e-13 Putamen volume; LUSC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg14552801 chr7:65878734 NA -0.43 -5.86 -0.31 1.09e-8 Aortic root size; LUSC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 8.61 0.43 2.89e-16 Alzheimer's disease; LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 3.07e-13 Prudent dietary pattern; LUSC cis rs1564271 0.506 rs1148163 chr10:26929671 G/C cg13837822 chr10:26931731 LOC731789 0.51 11.42 0.53 9.83e-26 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs921665 0.831 rs2167962 chr2:3192427 G/A cg02624386 chr2:3182749 NA 0.51 5.84 0.3 1.26e-8 World class endurance athleticism; LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg22963979 chr7:1858916 MAD1L1 -0.55 -8.21 -0.41 4.91e-15 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg22166914 chr1:53195759 ZYG11B -0.61 -10.23 -0.49 1.51e-21 Monocyte count; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4478858 0.684 rs4949374 chr1:31754511 G/C cg00250761 chr1:31883323 NA -0.33 -7.95 -0.4 2.9e-14 Alcohol dependence; LUSC cis rs4499344 0.693 rs8106944 chr19:33097783 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.66 0.57 2.92e-30 Mean platelet volume; LUSC cis rs7851660 0.809 rs10818241 chr9:100661972 A/G cg13688889 chr9:100608707 NA -0.54 -8.44 -0.42 9.53e-16 Strep throat; LUSC cis rs7927592 0.956 rs2510384 chr11:68391837 C/A cg01657329 chr11:68192670 LRP5 -0.45 -6.59 -0.34 1.68e-10 Total body bone mineral density; LUSC cis rs7615316 0.934 rs6440088 chr3:142270359 T/C cg16271453 chr3:142027066 XRN1 -0.37 -6.43 -0.33 4.53e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2832077 0.505 rs9305386 chr21:30386751 A/G cg03476357 chr21:30257390 N6AMT1 0.77 8.12 0.41 8.89e-15 Cognitive test performance; LUSC trans rs61931739 0.649 rs12424056 chr12:33714314 G/A cg26384229 chr12:38710491 ALG10B -0.42 -6.17 -0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg22638593 chr5:131593259 PDLIM4 0.4 5.91 0.31 8.41e-9 Breast cancer; LUSC cis rs1950626 0.750 rs35683125 chr14:101454750 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.8 0.39 8.17e-14 Pelvic organ prolapse (moderate/severe); LUSC cis rs6120849 0.754 rs6120813 chr20:33642112 T/C cg24642439 chr20:33292090 TP53INP2 0.6 6.58 0.34 1.8e-10 Protein C levels; LUSC cis rs7824557 0.564 rs2736304 chr8:11236964 C/T cg21775007 chr8:11205619 TDH -0.65 -10.23 -0.49 1.51e-21 Retinal vascular caliber; LUSC cis rs8017423 1.000 rs2184281 chr14:90685923 A/G cg04374321 chr14:90722782 PSMC1 -0.68 -10.15 -0.49 2.72e-21 Mortality in heart failure; LUSC cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs11229555 0.874 rs17567523 chr11:58354081 G/A cg15696309 chr11:58395628 NA -0.71 -9.19 -0.45 4.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg15691649 chr6:25882328 NA -0.39 -6.37 -0.33 6.13e-10 Blood metabolite levels; LUSC cis rs854765 0.654 rs11078400 chr17:17757728 A/G cg04398451 chr17:18023971 MYO15A 0.5 7.97 0.4 2.45e-14 Total body bone mineral density; LUSC cis rs6782228 0.527 rs2712371 chr3:128346214 G/A cg16766828 chr3:128327626 NA -0.31 -5.66 -0.3 3.3e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg21535247 chr6:8435926 SLC35B3 0.57 8.84 0.44 5.57e-17 Motion sickness; LUSC cis rs7953249 0.935 rs7135337 chr12:121404155 A/C cg02403541 chr12:121454288 C12orf43 -0.6 -9.28 -0.45 2.24e-18 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg08975724 chr8:8085496 FLJ10661 -0.49 -7.21 -0.37 3.75e-12 Mood instability; LUSC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.94 -0.31 7.03e-9 Life satisfaction; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg03576123 chr11:487126 PTDSS2 -0.97 -10.78 -0.51 1.95e-23 Body mass index; LUSC cis rs6964587 1.000 rs417 chr7:91581121 C/A cg01689657 chr7:91764605 CYP51A1 -0.32 -5.88 -0.31 9.85e-9 Breast cancer; LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg13047869 chr3:10149882 C3orf24 0.61 8.24 0.41 3.97e-15 Alzheimer's disease; LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC trans rs11098499 0.866 rs3756156 chr4:120524841 G/A cg25214090 chr10:38739885 LOC399744 0.52 7.87 0.4 4.87e-14 Corneal astigmatism; LUSC cis rs7845219 0.544 rs34293080 chr8:95908078 G/T cg13393036 chr8:95962371 TP53INP1 -0.31 -5.93 -0.31 7.65e-9 Type 2 diabetes; LUSC cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg06784218 chr1:46089804 CCDC17 -0.47 -8.92 -0.44 3.06e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9807841 0.592 rs10415961 chr19:10759981 G/C cg09936142 chr19:10668400 KRI1 -0.44 -7.08 -0.36 8.76e-12 Inflammatory skin disease; LUSC cis rs854765 0.587 rs4077828 chr17:17833644 A/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.55 -0.42 4.5e-16 Total body bone mineral density; LUSC cis rs2370759 1.000 rs11594963 chr10:32625736 G/A cg01819863 chr10:32635814 EPC1 1.03 12.78 0.57 1.0500000000000001e-30 Sexual dysfunction (female); LUSC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.31 -0.41 2.36e-15 Schizophrenia; LUSC cis rs11098499 0.954 rs12499324 chr4:120393786 C/T cg09307838 chr4:120376055 NA 0.79 11.5 0.53 5.34e-26 Corneal astigmatism; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg17541715 chr7:1216824 NA -0.39 -6.16 -0.32 2.09e-9 Longevity;Endometriosis; LUSC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg22963979 chr7:1858916 MAD1L1 -0.59 -9.04 -0.44 1.32e-17 Bipolar disorder and schizophrenia; LUSC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.61 -9.56 -0.46 2.66e-19 Height; LUSC cis rs2200578 1.000 rs116648076 chr2:99882347 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 0.57 6.61 0.34 1.53e-10 IgG glycosylation; LUSC cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs11148252 0.574 rs9536247 chr13:53279542 T/C cg00495681 chr13:53174319 NA 0.79 15.67 0.65 7.42e-42 Lewy body disease; LUSC trans rs12478296 0.591 rs12719765 chr2:242997202 C/G cg01596870 chr19:55963115 NA -0.54 -7.16 -0.36 5.31e-12 Obesity-related traits; LUSC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg06221963 chr1:154839813 KCNN3 -0.61 -13.87 -0.6 7.21e-35 Prostate cancer; LUSC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg25453430 chr21:37433068 SETD4 0.41 6.33 0.33 7.83e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg27432699 chr2:27873401 GPN1 -0.58 -8.91 -0.44 3.47e-17 Total body bone mineral density; LUSC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg18131467 chr2:239335373 ASB1 0.87 13.84 0.6 9.42e-35 Multiple system atrophy; LUSC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg17385448 chr1:15911702 AGMAT 0.37 6.31 0.33 8.9e-10 Systolic blood pressure; LUSC cis rs3770081 1.000 rs2241435 chr2:86360916 C/G cg01119172 chr2:86362222 SNORD94;PTCD3 0.83 5.88 0.31 9.86e-9 Facial emotion recognition (sad faces); LUSC cis rs4700695 0.668 rs20768 chr5:65484805 C/T cg21114390 chr5:65439923 SFRS12 -0.5 -6.93 -0.35 2.12e-11 Facial morphology (factor 19); LUSC cis rs7937682 0.564 rs1944116 chr11:111366792 A/C cg09085632 chr11:111637200 PPP2R1B 0.44 5.84 0.3 1.24e-8 Primary sclerosing cholangitis; LUSC cis rs1144713 0.686 rs1144714 chr12:32261252 A/C cg01321189 chr12:32259338 BICD1 0.43 6.63 0.34 1.37e-10 Obesity-related traits; LUSC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg27286337 chr10:134555280 INPP5A 0.91 11.53 0.53 3.98e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6693567 0.565 rs1260457 chr1:150347374 G/A cg15654264 chr1:150340011 RPRD2 0.46 7.36 0.37 1.42e-12 Migraine; LUSC trans rs2048656 0.605 rs7837008 chr8:9646506 T/C cg15556689 chr8:8085844 FLJ10661 0.46 6.47 0.33 3.55e-10 Schizophrenia; LUSC cis rs4076764 0.801 rs12046142 chr1:163375247 G/A cg24596788 chr1:163392923 NA -0.38 -6.48 -0.33 3.3e-10 Motion sickness; LUSC cis rs965469 1.000 rs6051709 chr20:3263685 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.93 -0.31 7.54e-9 IFN-related cytopenia; LUSC cis rs13256369 0.802 rs12153 chr8:8560909 G/C cg17143192 chr8:8559678 CLDN23 0.67 9.31 0.45 1.75e-18 Obesity-related traits; LUSC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg27532560 chr4:187881888 NA -0.39 -6.34 -0.33 7.63e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs765787 0.530 rs2899379 chr15:45534799 C/T cg25801113 chr15:45476975 SHF -0.35 -6.98 -0.36 1.58e-11 Uric acid levels; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.75e-17 Prudent dietary pattern; LUSC cis rs7647973 0.626 rs62260720 chr3:49853796 T/A cg03060546 chr3:49711283 APEH -0.61 -7.2 -0.37 3.89e-12 Menarche (age at onset); LUSC cis rs9952991 0.941 rs2847278 chr18:12778715 C/T cg23544223 chr18:12777786 NA 0.59 6.27 0.32 1.15e-9 Inflammatory skin disease; LUSC cis rs28374715 0.681 rs28687846 chr15:41599902 C/T cg18705301 chr15:41695430 NDUFAF1 -1.03 -20.36 -0.74 1.76e-60 Ulcerative colitis; LUSC cis rs1018836 0.608 rs10111060 chr8:91491152 T/C cg16814680 chr8:91681699 NA -0.63 -9.43 -0.46 7.18e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4144743 0.938 rs35439279 chr17:45321694 C/T cg18085866 chr17:45331354 ITGB3 -0.75 -8.07 -0.4 1.26e-14 Body mass index; LUSC cis rs7772486 0.875 rs864390 chr6:146315035 G/T cg05347473 chr6:146136440 FBXO30 0.51 8.46 0.42 8.73e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg10253484 chr15:75165896 SCAMP2 -0.39 -5.65 -0.3 3.48e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs9921338 0.961 rs72773829 chr16:11412623 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.75 -0.35 6.73e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg00033643 chr7:134001901 SLC35B4 0.46 7.22 0.37 3.63e-12 Mean platelet volume; LUSC cis rs314370 0.951 rs3757868 chr7:100482720 G/A cg10426581 chr7:100472382 SRRT 0.86 12.47 0.56 1.43e-29 Resting heart rate; LUSC cis rs897984 0.806 rs12928852 chr16:30943988 C/T cg02466173 chr16:30829666 NA 0.56 11.3 0.53 2.68e-25 Dementia with Lewy bodies; LUSC cis rs1003719 0.788 rs7276917 chr21:38451334 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.71 11.64 0.54 1.63e-26 Eye color traits; LUSC cis rs9650315 0.866 rs28538240 chr8:57182945 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.48 0.42 7.57e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg26513180 chr16:89883248 FANCA 0.89 16.17 0.66 7.53e-44 Vitiligo; LUSC cis rs2832077 0.943 rs2832106 chr21:30191767 A/G cg08807101 chr21:30365312 RNF160 -0.53 -6.68 -0.34 9.85e-11 Cognitive test performance; LUSC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg05754148 chr16:3507555 NAT15 0.52 7.85 0.39 5.54e-14 Tuberculosis; LUSC cis rs7267979 0.932 rs372678 chr20:25465248 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.21 0.74 6.52e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg13318129 chr22:45737514 FAM118A 0.7 8.48 0.42 7.4e-16 Tonsillectomy; LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg22166914 chr1:53195759 ZYG11B -0.62 -10.26 -0.49 1.21e-21 Monocyte count; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg08771429 chr7:91876374 KRIT1;ANKIB1 0.41 6.03 0.31 4.43e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2625529 0.775 rs12913042 chr15:72202309 C/T cg16672083 chr15:72433130 SENP8 -0.49 -7.24 -0.37 3.18e-12 Red blood cell count; LUSC trans rs62103177 0.608 rs8088089 chr18:77832154 A/G cg05926928 chr17:57297772 GDPD1 -0.9 -10.33 -0.49 6.63e-22 Opioid sensitivity; LUSC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg26958806 chr6:27640298 NA 0.69 5.91 0.31 8.22e-9 Depression; LUSC trans rs9944715 1.000 rs4890628 chr18:43788045 T/C cg01718231 chr17:29326311 RNF135 -0.5 -7.06 -0.36 9.81e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg03233332 chr7:66118400 NA -0.41 -5.97 -0.31 6.03e-9 Aortic root size; LUSC cis rs9393692 0.902 rs6456711 chr6:26302572 A/C cg13736514 chr6:26305472 NA -0.48 -9.6 -0.46 1.99e-19 Educational attainment; LUSC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.46 -0.38 7.39e-13 Bipolar disorder; LUSC cis rs2307022 0.586 rs3785126 chr16:68388661 C/T cg02226672 chr16:68398533 SMPD3 0.33 6.15 0.32 2.25e-9 Body mass index; LUSC cis rs72781680 1.000 rs55773155 chr2:24255081 A/G cg20701182 chr2:24300061 SF3B14 0.82 8.15 0.41 7.36e-15 Lymphocyte counts; LUSC cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg24596788 chr1:163392923 NA -0.45 -7.62 -0.38 2.6e-13 Motion sickness; LUSC cis rs76878669 0.561 rs56321771 chr11:66161072 C/T cg24851651 chr11:66362959 CCS -0.38 -6.06 -0.31 3.72e-9 Educational attainment (years of education); LUSC cis rs7568458 0.870 rs1562323 chr2:85809711 T/C cg23752985 chr2:85803571 VAMP8 0.37 8.19 0.41 5.69e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs11165623 0.740 rs11165638 chr1:96921357 C/A cg10631902 chr5:14652156 NA -0.55 -8.98 -0.44 1.97e-17 Hip circumference;Waist circumference; LUSC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg24110177 chr3:50126178 RBM5 -0.55 -9.05 -0.44 1.22e-17 Intelligence (multi-trait analysis); LUSC cis rs2303282 0.716 rs12445699 chr16:56452584 A/G cg00500540 chr16:56394104 NA -0.43 -7.37 -0.37 1.37e-12 Breast cancer; LUSC cis rs7617773 0.694 rs13099560 chr3:48204768 C/T cg20734569 chr3:48348370 SPINK8 0.46 8.19 0.41 5.74e-15 Coronary artery disease; LUSC cis rs1023500 0.505 rs134878 chr22:42663874 A/G cg04733989 chr22:42467013 NAGA 0.53 8.18 0.41 5.88e-15 Schizophrenia; LUSC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -8.21 -0.41 4.76e-15 Cystic fibrosis severity; LUSC cis rs3087591 0.664 rs2854308 chr17:29666539 A/G cg24425628 chr17:29625626 OMG;NF1 0.47 7.23 0.37 3.33e-12 Hip circumference; LUSC trans rs8072100 0.840 rs9912311 chr17:45547132 T/C cg03886242 chr7:26192032 NFE2L3 -0.39 -6.3 -0.33 9.43e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3820928 1.000 rs1835158 chr2:227763993 C/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.77 -0.39 9.77e-14 Pulmonary function; LUSC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg12365402 chr11:9010492 NRIP3 0.47 8.79 0.43 8.12e-17 Hemoglobin concentration; LUSC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg01879757 chr17:41196368 BRCA1 -0.47 -7.16 -0.36 5.11e-12 Menopause (age at onset); LUSC cis rs9790314 0.875 rs462514 chr3:161092809 C/T cg03342759 chr3:160939853 NMD3 -0.51 -8.44 -0.42 9.48e-16 Morning vs. evening chronotype; LUSC cis rs6961069 0.806 rs10499859 chr7:80258810 A/G cg04458919 chr7:80252533 CD36 0.37 6.74 0.35 7.09e-11 Platelet count; LUSC cis rs7590368 0.683 rs72779445 chr2:10957707 G/C cg15705551 chr2:10952987 PDIA6 0.57 6.12 0.32 2.64e-9 Educational attainment (years of education); LUSC cis rs1401999 0.510 rs12634398 chr3:183708405 A/G cg01324343 chr3:183735012 ABCC5 0.49 9.87 0.48 2.5e-20 Anterior chamber depth; LUSC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.23 -0.37 3.29e-12 Major depressive disorder; LUSC cis rs6163 0.588 rs10786706 chr10:104500659 C/T cg04362960 chr10:104952993 NT5C2 0.45 6.75 0.35 6.5500000000000006e-11 Waist circumference;Hip circumference; LUSC cis rs11809207 0.723 rs57653638 chr1:26524401 A/G cg00300879 chr1:26503847 CNKSR1 0.3 5.75 0.3 2.01e-8 Height; LUSC cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg08822215 chr16:89438651 ANKRD11 0.38 5.89 0.31 9.26e-9 Multiple myeloma (IgH translocation); LUSC cis rs1215050 0.818 rs6532703 chr4:98777486 A/T cg05340658 chr4:99064831 C4orf37 0.41 6.24 0.32 1.31e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg24675658 chr1:53192096 ZYG11B 0.61 9.78 0.47 4.83e-20 Monocyte count; LUSC cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.83 -0.54 3.32e-27 Chronic sinus infection; LUSC cis rs11997175 0.603 rs12156112 chr8:33791598 T/C ch.8.33884649F chr8:33765107 NA 0.42 6.37 0.33 6.35e-10 Body mass index; LUSC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.8 -0.3 1.55e-8 Tonsillectomy; LUSC cis rs2236918 1.000 rs851782 chr1:242033783 A/G cg17736920 chr1:242011382 EXO1 0.44 6.81 0.35 4.48e-11 Menopause (age at onset); LUSC cis rs4285028 0.948 rs13089878 chr3:121703895 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.71 -9.24 -0.45 3.07e-18 Multiple sclerosis; LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg08200582 chr11:442649 ANO9 -0.51 -5.98 -0.31 5.68e-9 Body mass index; LUSC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg16339924 chr4:17578868 LAP3 0.56 8.67 0.43 1.94e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2540226 0.550 rs13401182 chr2:39932807 G/A cg23576258 chr2:39999331 THUMPD2 0.38 6.38 0.33 5.82e-10 Personality dimensions; LUSC cis rs6005807 0.719 rs9625513 chr22:29022172 C/T cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC trans rs782590 0.967 rs62165172 chr2:55736237 A/G cg22328901 chr2:86333256 PTCD3;POLR1A 0.41 5.98 0.31 5.75e-9 Metabolic syndrome; LUSC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg17554472 chr22:41940697 POLR3H 0.48 5.9 0.31 8.76e-9 Vitiligo; LUSC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg03036452 chr22:46663545 TTC38 0.58 5.76 0.3 1.88e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs2762353 0.935 rs11754288 chr6:25776949 G/A cg12310025 chr6:25882481 NA 0.4 6.88 0.35 2.92e-11 Blood metabolite levels; LUSC trans rs6582630 0.502 rs3902522 chr12:38271203 T/C cg06521331 chr12:34319734 NA -0.41 -6.38 -0.33 5.95e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11644478 chr21:40555479 PSMG1 0.94 18.89 0.72 1.15e-54 Cognitive function; LUSC cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg00083206 chr6:110721305 DDO 0.45 8.27 0.41 3.22e-15 Platelet distribution width; LUSC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg23172400 chr8:95962367 TP53INP1 0.31 6.25 0.32 1.28e-9 Type 2 diabetes; LUSC cis rs950776 0.593 rs601079 chr15:78869579 T/A cg06917634 chr15:78832804 PSMA4 -0.74 -12.75 -0.57 1.29e-30 Sudden cardiac arrest; LUSC cis rs6961069 0.585 rs10265780 chr7:80255369 A/G cg04458919 chr7:80252533 CD36 -0.38 -6.75 -0.35 6.37e-11 Platelet count; LUSC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg12292205 chr6:26970375 C6orf41 -0.69 -12.15 -0.55 2.25e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs7428496 0.528 rs13085261 chr3:142242287 G/A cg16271453 chr3:142027066 XRN1 -0.51 -8.77 -0.43 9.61e-17 Mean corpuscular hemoglobin; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.38 -0.42 1.45e-15 Lymphocyte counts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07148880 chr1:200992788 KIF21B 0.47 6.3 0.33 9.62e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg16434002 chr17:42200994 HDAC5 -0.49 -6.9 -0.35 2.66e-11 Total body bone mineral density; LUSC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs9467773 1.000 rs1056667 chr6:26510564 T/C cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.8e-18 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs2129243 chr16:48646852 A/T cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.93e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9399135 0.967 rs4637662 chr6:135298158 T/C cg24558204 chr6:135376177 HBS1L 0.59 9.11 0.45 7.58e-18 Red blood cell count; LUSC cis rs4499344 0.526 rs11084655 chr19:33034698 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 10.28 0.49 1.02e-21 Mean platelet volume; LUSC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20360273 chr2:70056711 GMCL1 -0.48 -7.42 -0.38 9.65e-13 Electrocardiographic conduction measures; LUSC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg04518342 chr5:131593106 PDLIM4 0.55 10.37 0.49 4.93e-22 Acylcarnitine levels; LUSC trans rs1448094 0.817 rs10863111 chr12:86330615 T/C cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg11608241 chr8:8085544 FLJ10661 -0.42 -6.07 -0.32 3.52e-9 Mood instability; LUSC cis rs7216064 1.000 rs73352808 chr17:65875157 G/A cg12091567 chr17:66097778 LOC651250 -0.74 -9.32 -0.45 1.62e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs1728785 0.792 rs1111502 chr16:68581209 A/G cg02972257 chr16:68554789 NA -0.47 -6.13 -0.32 2.46e-9 Ulcerative colitis; LUSC cis rs5769707 0.837 rs1573726 chr22:50032872 G/A cg01652190 chr22:50026171 C22orf34 -0.28 -5.92 -0.31 7.95e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8062405 1.000 rs62037365 chr16:28868962 C/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs208520 0.802 rs208496 chr6:66930786 G/C cg07460842 chr6:66804631 NA -1.01 -14.2 -0.61 3.96e-36 Exhaled nitric oxide output; LUSC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg22823121 chr1:150693482 HORMAD1 0.54 7.74 0.39 1.17e-13 Melanoma; LUSC cis rs2806561 0.765 rs2806557 chr1:23503372 T/A cg12483005 chr1:23474871 LUZP1 0.39 5.96 0.31 6.41e-9 Height; LUSC cis rs73198271 0.681 rs35457364 chr8:8649790 T/A cg01851573 chr8:8652454 MFHAS1 0.53 8.49 0.42 7.11e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg20406979 chr6:167373233 NA 0.25 6.03 0.31 4.37e-9 Crohn's disease; LUSC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.86 -0.31 1.09e-8 Tonsillectomy; LUSC cis rs4356932 1.000 rs6857372 chr4:76974727 C/T cg00809888 chr4:76862425 NAAA 0.35 5.83 0.3 1.33e-8 Blood protein levels; LUSC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.73 0.35 7.49e-11 Tonsillectomy; LUSC cis rs1003719 0.762 rs3787780 chr21:38462614 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.31 0.53 2.41e-25 Eye color traits; LUSC cis rs10992471 0.603 rs10116813 chr9:95090360 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.52 -8.38 -0.42 1.46e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9297145 0.916 rs4236540 chr7:98769025 A/C cg05967295 chr7:98741636 SMURF1 0.91 16.38 0.67 1.09e-44 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg00484396 chr16:3507460 NAT15 -0.45 -7.31 -0.37 2.03e-12 Body mass index (adult); LUSC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.48 5.72 0.3 2.39e-8 Renal function-related traits (BUN); LUSC cis rs6500602 0.927 rs7200817 chr16:4480598 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.45 5.97 0.31 6.2e-9 Schizophrenia; LUSC cis rs1577917 1.000 rs7771342 chr6:86631936 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC trans rs9944275 0.860 rs34169909 chr15:97189563 T/C cg18834029 chr10:103349097 POLL;RP11-529I10.4 -0.6 -5.97 -0.31 6.23e-9 Depressive symptoms (multi-trait analysis);Neuroticism (multi-trait analysis); LUSC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg18404041 chr3:52824283 ITIH1 -0.58 -9.89 -0.48 2.17e-20 Schizophrenia; LUSC cis rs9309711 0.961 rs11675119 chr2:3476422 C/A cg10845886 chr2:3471009 TTC15 -0.63 -8.24 -0.41 4.09e-15 Neurofibrillary tangles; LUSC cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg05347473 chr6:146136440 FBXO30 0.45 7.7 0.39 1.61e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12220238 0.730 rs11000899 chr10:75913055 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.92 0.35 2.36e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg07256732 chr16:621771 PIGQ -0.37 -6.5 -0.34 2.89e-10 Height; LUSC trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg05911100 chr12:8333192 FAM66C -0.36 -6.16 -0.32 2.12e-9 Neuroticism; LUSC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg24250549 chr1:154909240 PMVK 0.6 9.76 0.47 5.94e-20 Prostate cancer; LUSC cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs244293 0.965 rs244305 chr17:53237843 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.93 -0.31 7.63e-9 Menarche (age at onset); LUSC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg26769984 chr7:1090371 C7orf50 0.7 9.84 0.47 3.06e-20 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg24829409 chr8:58192753 C8orf71 -0.56 -6.43 -0.33 4.31e-10 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg13560548 chr3:10150139 C3orf24 0.51 7.05 0.36 1.04e-11 Alzheimer's disease; LUSC cis rs10791097 0.694 rs7926167 chr11:130745045 T/C cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg00376283 chr12:123451042 ABCB9 -0.69 -9.82 -0.47 3.77e-20 Neutrophil percentage of white cells; LUSC cis rs1801251 1.000 rs991873 chr2:233711046 A/G cg08000102 chr2:233561755 GIGYF2 -0.69 -11.5 -0.53 5.13e-26 Coronary artery disease; LUSC cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg27279351 chr12:120934652 DYNLL1 0.65 8.76 0.43 1.01e-16 High light scatter reticulocyte count; LUSC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg16586182 chr3:47516702 SCAP -0.49 -7.71 -0.39 1.43e-13 Colorectal cancer; LUSC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg06671706 chr8:8559999 CLDN23 0.51 6.71 0.34 8.45e-11 Obesity-related traits; LUSC cis rs6987853 0.814 rs2923415 chr8:42455577 A/G cg09913449 chr8:42400586 C8orf40 0.42 6.91 0.35 2.47e-11 Mean corpuscular hemoglobin concentration; LUSC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg15147215 chr3:52552868 STAB1 -0.31 -6.11 -0.32 2.79e-9 Bipolar disorder; LUSC cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg22709100 chr7:91322751 NA 0.38 5.64 0.3 3.57e-8 Breast cancer; LUSC cis rs2637266 1.000 rs2894339 chr10:78354104 G/A cg18941641 chr10:78392320 NA 0.39 7.17 0.37 4.97e-12 Pulmonary function; LUSC cis rs1044826 0.667 rs2083336 chr3:139201272 T/G cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.86e-11 Obesity-related traits; LUSC cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg07148914 chr20:33460835 GGT7 0.54 8.25 0.41 3.63e-15 Height; LUSC trans rs17133449 0.718 rs2167695 chr10:4753980 G/C cg17844448 chr7:27782764 TAX1BP1 -0.38 -6.2 -0.32 1.68e-9 Major depressive disorder; LUSC trans rs561341 0.943 rs508566 chr17:30289861 G/C cg20587970 chr11:113659929 NA -1.27 -17.1 -0.68 1.53e-47 Hip circumference adjusted for BMI; LUSC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg23422044 chr7:1970798 MAD1L1 -0.66 -7.51 -0.38 5.6e-13 Bipolar disorder; LUSC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg02117656 chr17:79614917 TSPAN10 -0.31 -5.67 -0.3 3.13e-8 Eye color traits; LUSC trans rs2243480 1.000 rs1167613 chr7:65487439 C/T cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.59e-15 Diabetic kidney disease; LUSC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.86e-12 Blood metabolite levels; LUSC cis rs941408 0.515 rs1640265 chr19:2784405 C/T cg17333051 chr19:2783644 SGTA 0.46 6.81 0.35 4.44e-11 Total cholesterol levels; LUSC cis rs7113850 0.541 rs80031332 chr11:24211553 A/G ch.11.24196551F chr11:24239977 NA 0.95 7.4 0.38 1.14e-12 Bone fracture in osteoporosis; LUSC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg11645453 chr3:52864694 ITIH4 -0.37 -8.1 -0.41 1.07e-14 Bipolar disorder; LUSC trans rs1997103 0.911 rs10238738 chr7:55412359 T/C cg20935933 chr6:143382018 AIG1 0.51 7.38 0.37 1.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg04944784 chr2:26401820 FAM59B -0.69 -9.55 -0.46 2.86e-19 Gut microbiome composition (summer); LUSC cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg02423579 chr7:2872169 GNA12 -0.37 -5.68 -0.3 2.96e-8 Height; LUSC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg23630131 chr7:65973040 NA -0.21 -5.84 -0.3 1.27e-8 Aortic root size; LUSC cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg24642439 chr20:33292090 TP53INP2 0.74 12.05 0.55 5.08e-28 Coronary artery disease; LUSC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 8.85 0.44 5.34e-17 Schizophrenia; LUSC cis rs672059 1.000 rs3120034 chr1:183167051 A/G ch.1.3577855R chr1:183094577 LAMC1 0.59 8.72 0.43 1.36e-16 Hypertriglyceridemia; LUSC cis rs6120849 0.951 rs6120848 chr20:33728678 T/C cg24642439 chr20:33292090 TP53INP2 0.56 6.19 0.32 1.78e-9 Protein C levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07542287 chr2:240046312 HDAC4 -0.77 -6.48 -0.33 3.28e-10 Cognitive performance; LUSC cis rs3764563 1.000 rs4371280 chr19:15715768 A/C cg20725493 chr19:15740067 CYP4F8 -0.67 -6.55 -0.34 2.2e-10 Inflammatory biomarkers; LUSC trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg27661571 chr11:113659931 NA 0.64 6.14 0.32 2.4e-9 Hip circumference adjusted for BMI; LUSC cis rs4423214 0.592 rs3829251 chr11:71194559 G/A cg05163923 chr11:71159392 DHCR7 -0.65 -6.94 -0.35 2.1e-11 Vitamin D levels; LUSC cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.67 -0.43 1.84e-16 Uric acid levels; LUSC cis rs1559088 1.000 rs7256328 chr19:33558705 G/C cg17764715 chr19:33622953 WDR88 0.59 7.9 0.4 4.06e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg10802521 chr3:52805072 NEK4 -0.58 -9.45 -0.46 6.09e-19 Bipolar disorder; LUSC trans rs262741 0.538 rs7728710 chr5:165186172 C/T cg02631838 chr1:33358788 HPCA 0.34 6.03 0.31 4.43e-9 Lewy body disease; LUSC cis rs12042938 0.600 rs823163 chr1:231771108 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.43 6.45 0.33 3.87e-10 Neuranatomic and neurocognitive phenotypes; LUSC cis rs2404602 0.692 rs66866130 chr15:77128574 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.01 0.36 1.35e-11 Blood metabolite levels; LUSC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg02187348 chr16:89574699 SPG7 0.5 7.94 0.4 3.09e-14 Multiple myeloma (IgH translocation); LUSC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg14416269 chr4:6271139 WFS1 0.41 6.65 0.34 1.22e-10 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs66887589 0.616 rs13113885 chr4:120221176 G/C cg25214090 chr10:38739885 LOC399744 0.4 6.18 0.32 1.89e-9 Diastolic blood pressure; LUSC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg04800585 chr6:26043546 HIST1H2BB 0.42 6.02 0.31 4.51e-9 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs6500398 chr16:48650332 C/T cg04672837 chr16:48644449 N4BP1 0.48 6.98 0.36 1.56e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg11764359 chr7:65958608 NA 0.8 13.17 0.58 3.4e-32 Aortic root size; LUSC cis rs9549367 0.789 rs6577031 chr13:113878182 T/C cg18105134 chr13:113819100 PROZ 0.64 9.75 0.47 6.36e-20 Platelet distribution width; LUSC cis rs7312933 0.558 rs1051453 chr12:42852217 C/T cg01256987 chr12:42539512 GXYLT1 -0.39 -7.11 -0.36 7.2e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.09 0.4 1.15e-14 Axial length; LUSC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11890956 chr21:40555474 PSMG1 -0.82 -14.17 -0.61 5.01e-36 Cognitive function; LUSC cis rs9951602 0.607 rs3017651 chr18:76668622 T/C cg00806245 chr18:76673096 NA -0.43 -6.74 -0.35 6.83e-11 Obesity-related traits; LUSC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg22681709 chr2:178499509 PDE11A -0.48 -8.8 -0.43 7.7e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9902453 0.791 rs3115100 chr17:28045744 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.21 0.52 5.66e-25 Coffee consumption (cups per day); LUSC trans rs62103177 0.733 rs62096748 chr18:77619699 T/C cg05926928 chr17:57297772 GDPD1 1.43 17.37 0.69 1.32e-48 Opioid sensitivity; LUSC cis rs17854409 0.881 rs6011430 chr20:61497014 C/T cg05147244 chr20:61493195 TCFL5 -0.88 -7.99 -0.4 2.15e-14 Obesity-related traits; LUSC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg13628971 chr7:2884303 GNA12 0.41 6.31 0.33 8.92e-10 Height; LUSC cis rs73591976 0.539 rs12446198 chr16:68125972 G/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.33 -0.37 1.78e-12 HDL cholesterol; LUSC cis rs1580019 0.922 rs59938271 chr7:32484844 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.83 12.19 0.55 1.6e-28 Cognitive ability; LUSC cis rs922692 0.715 rs11632102 chr15:79086057 G/A cg00540400 chr15:79124168 NA -0.42 -7.25 -0.37 2.94e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7296418 0.961 rs10848428 chr12:123572495 C/T cg00376283 chr12:123451042 ABCB9 0.81 12.52 0.57 9.78e-30 Platelet count; LUSC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg04414720 chr1:150670196 GOLPH3L -0.48 -7.79 -0.39 8.75e-14 Tonsillectomy; LUSC cis rs1670533 1.000 rs2290411 chr4:1051077 T/C cg27284194 chr4:1044797 NA 0.57 8.42 0.42 1.12e-15 Recombination rate (females); LUSC cis rs9435341 0.826 rs1730858 chr1:107619244 T/C cg00944433 chr1:107599041 PRMT6 0.34 6.22 0.32 1.53e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs1943345 0.830 rs571055 chr11:82898829 G/C cg07047830 chr11:82868014 PCF11 0.52 6.42 0.33 4.57e-10 Obesity-related traits; LUSC cis rs35146811 0.844 rs59261051 chr7:99650429 C/T cg22906224 chr7:99728672 NA 0.53 7.68 0.39 1.83e-13 Coronary artery disease; LUSC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg23172400 chr8:95962367 TP53INP1 -0.4 -8.42 -0.42 1.12e-15 Type 2 diabetes; LUSC cis rs422249 0.547 rs174536 chr11:61551927 A/C cg19610905 chr11:61596333 FADS2 -0.54 -8.19 -0.41 5.58e-15 Trans fatty acid levels; LUSC cis rs2742417 0.603 rs2742371 chr3:45782763 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.45 -0.38 8.27e-13 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs7824557 0.583 rs2263512 chr8:11233419 T/G cg08975724 chr8:8085496 FLJ10661 -0.46 -6.77 -0.35 5.85e-11 Retinal vascular caliber; LUSC cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs1957429 0.520 rs77606588 chr14:65356268 G/A cg23373153 chr14:65346875 NA -1.01 -8.51 -0.42 6.09e-16 Pediatric areal bone mineral density (radius); LUSC cis rs244731 0.919 rs12652509 chr5:176626441 A/G cg16006841 chr5:176797999 RGS14 -0.66 -9.25 -0.45 2.82e-18 Urate levels in lean individuals; LUSC cis rs709400 0.663 rs11624367 chr14:103892818 T/A cg24130564 chr14:104152367 KLC1 -0.46 -6.36 -0.33 6.47e-10 Body mass index; LUSC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg27539214 chr16:67997921 SLC12A4 -0.58 -7.57 -0.38 3.57e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9814567 0.896 rs6799110 chr3:134206749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.85 -14.33 -0.62 1.22e-36 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12586317 0.620 rs76293361 chr14:35570889 G/A cg05294307 chr14:35346193 BAZ1A -0.56 -6.74 -0.35 6.84e-11 Psoriasis; LUSC cis rs11958404 0.932 rs72816542 chr5:157416402 C/T cg05962755 chr5:157440814 NA 0.56 6.55 0.34 2.22e-10 IgG glycosylation; LUSC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.06 22.51 0.78 6.26e-69 Height; LUSC cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg08917208 chr2:24149416 ATAD2B 0.53 5.97 0.31 6e-9 Lymphocyte counts; LUSC cis rs72960926 0.744 rs72953763 chr6:74983753 G/C cg03266952 chr6:74778945 NA -0.82 -6.99 -0.36 1.49e-11 Metabolite levels (MHPG); LUSC cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg23158103 chr7:148848205 ZNF398 -0.5 -8.35 -0.42 1.88e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs13082711 0.911 rs6777272 chr3:27488310 T/G cg02860705 chr3:27208620 NA 0.5 8.11 0.41 1e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs3020736 0.500 rs4147638 chr22:42487900 G/A cg05082376 chr22:42548792 NA 0.43 6.59 0.34 1.73e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7681440 0.904 rs3806789 chr4:90759556 C/T cg20003494 chr4:90757398 SNCA -0.34 -5.71 -0.3 2.55e-8 Dementia with Lewy bodies; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.07 -0.48 5.1e-21 Obesity-related traits; LUSC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.66 6.33 0.33 7.76e-10 Cerebrospinal P-tau181p levels; LUSC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.42 -0.46 7.9e-19 Chronic sinus infection; LUSC cis rs10779751 0.686 rs2791656 chr1:11128329 A/G cg08854313 chr1:11322531 MTOR 0.84 12.47 0.56 1.51e-29 Body mass index; LUSC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs1215050 0.791 rs11729826 chr4:98657190 G/T cg05340658 chr4:99064831 C4orf37 -0.46 -7.26 -0.37 2.68e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4704187 0.687 rs6864324 chr5:74497885 C/T cg03227963 chr5:74354835 NA -0.32 -6.91 -0.35 2.43e-11 Response to amphetamines; LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg04166393 chr7:2884313 GNA12 0.44 6.05 0.31 3.86e-9 Height; LUSC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg06212747 chr3:49208901 KLHDC8B 0.43 5.86 0.31 1.1e-8 Parkinson's disease; LUSC cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14442939 chr10:27389572 ANKRD26 0.85 9.88 0.48 2.24e-20 Breast cancer; LUSC trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg20587970 chr11:113659929 NA -1.22 -16.33 -0.67 1.76e-44 Hip circumference adjusted for BMI; LUSC cis rs11719291 0.915 rs1048940 chr3:48725707 C/T cg00383909 chr3:49044727 WDR6 1.5 10.72 0.51 3.09e-23 Cognitive function; LUSC cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs4343996 0.869 rs4719944 chr7:3496032 A/G cg21248987 chr7:3385318 SDK1 0.37 6.1 0.32 2.86e-9 Motion sickness; LUSC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg12463550 chr7:65579703 CRCP -0.46 -6.78 -0.35 5.34e-11 Aortic root size; LUSC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC cis rs12410462 0.681 rs6670816 chr1:227610592 G/T cg04117972 chr1:227635322 NA -0.69 -7.56 -0.38 3.89e-13 Major depressive disorder; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19527946 chr21:46293646 PTTG1IP -0.44 -6.32 -0.33 8.37e-10 Electrocardiographic conduction measures; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14103574 chr5:162932455 MAT2B 0.48 7.39 0.37 1.19e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10191773 0.535 rs56048537 chr2:113078467 G/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.84 9.5 0.46 4.31e-19 Yeast infection; LUSC trans rs7568458 0.837 rs35215812 chr2:85792384 G/A cg11197913 chr1:145054779 PDE4DIP 0.33 6.01 0.31 4.91e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs2836974 0.613 rs2245455 chr21:40548087 A/T cg10577346 chr11:8704225 RPL27A -0.44 -6.53 -0.34 2.42e-10 Cognitive function; LUSC cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg12935359 chr14:103987150 CKB -0.52 -8.03 -0.4 1.66e-14 Body mass index; LUSC cis rs62432291 0.681 rs2932988 chr6:159655402 A/G cg14500486 chr6:159655392 FNDC1 -0.52 -5.86 -0.31 1.14e-8 Joint mobility (Beighton score); LUSC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg20203395 chr5:56204925 C5orf35 -0.57 -8.3 -0.41 2.59e-15 Coronary artery disease; LUSC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg18350739 chr11:68623251 NA -0.37 -6.67 -0.34 1.09e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs611744 0.743 rs2514843 chr8:109063434 C/T cg18478394 chr8:109455254 TTC35 0.42 6.13 0.32 2.54e-9 Dupuytren's disease; LUSC cis rs4144743 1.000 rs35704663 chr17:45327321 T/G cg18085866 chr17:45331354 ITGB3 -0.75 -7.79 -0.39 8.26e-14 Body mass index; LUSC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg14416269 chr4:6271139 WFS1 0.52 11.11 0.52 1.3e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs36093844 0.898 rs12363602 chr11:85596401 T/A cg25872744 chr11:85566296 CCDC83 -0.41 -5.87 -0.31 1.03e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs907612 0.638 rs11041476 chr11:1875067 C/T cg05305434 chr11:1874049 LSP1 0.32 5.99 0.31 5.55e-9 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC trans rs4713118 0.547 rs2116981 chr6:28067951 T/G cg06606381 chr12:133084897 FBRSL1 -0.47 -6.11 -0.32 2.77e-9 Parkinson's disease; LUSC cis rs7000551 0.751 rs2443505 chr8:22375341 G/A cg12081754 chr8:22256438 SLC39A14 0.46 6.92 0.35 2.37e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs5769707 0.935 rs739239 chr22:50050468 G/A cg07959070 chr22:50026188 C22orf34 -0.36 -7.26 -0.37 2.79e-12 Monocyte count;Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26817334 chr2:119613580 NA 0.43 6.22 0.32 1.45e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9581857 0.685 rs9319368 chr13:28042275 T/G cg22138327 chr13:27999177 GTF3A 0.74 8.04 0.4 1.53e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs16912285 0.748 rs7104550 chr11:24345162 A/G ch.11.24196551F chr11:24239977 NA 0.77 7.01 0.36 1.32e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs877282 0.838 rs34778553 chr10:796865 T/C cg13042288 chr15:90349979 ANPEP -0.48 -7.1 -0.36 7.58e-12 Uric acid levels; LUSC cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.38 7.6 0.38 3e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs62103177 0.525 rs4283293 chr18:77759582 A/G cg02751453 chr18:77725136 HSBP1L1 0.44 5.99 0.31 5.48e-9 Opioid sensitivity; LUSC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg22166914 chr1:53195759 ZYG11B -0.67 -11.3 -0.53 2.74e-25 Monocyte count; LUSC trans rs7824557 0.628 rs11250129 chr8:11202154 G/A cg08975724 chr8:8085496 FLJ10661 0.42 6.06 0.31 3.61e-9 Retinal vascular caliber; LUSC cis rs3755132 0.929 rs6743036 chr2:15767761 G/A cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg02018176 chr4:1364513 KIAA1530 -0.56 -9.76 -0.47 5.87e-20 Obesity-related traits; LUSC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg11645453 chr3:52864694 ITIH4 -0.34 -7.8 -0.39 8.18e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs500891 0.504 rs1145897 chr6:84040440 C/T cg08257003 chr6:84140564 ME1 0.34 8.09 0.4 1.08e-14 Platelet-derived growth factor BB levels; LUSC trans rs1005277 0.579 rs2505237 chr10:38438898 T/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.34 -0.46 1.42e-18 Extrinsic epigenetic age acceleration; LUSC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg06060754 chr5:176797920 RGS14 0.56 8.53 0.42 5.16e-16 Urinary electrolytes (magnesium/calcium ratio); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg27378424 chr22:31795766 DRG1 0.47 6.1 0.32 2.86e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7772486 0.806 rs4075695 chr6:146250959 A/G cg13319975 chr6:146136371 FBXO30 0.47 7.24 0.37 3.19e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg26384229 chr12:38710491 ALG10B 0.91 15.7 0.65 5.46e-42 Morning vs. evening chronotype; LUSC trans rs9944715 0.954 rs4890319 chr18:43812644 T/A cg01718231 chr17:29326311 RNF135 -0.54 -7.64 -0.39 2.38e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs9831754 1.000 rs9831754 chr3:78353591 A/C cg06138941 chr3:78371609 NA -0.74 -10.48 -0.5 2.11e-22 Calcium levels; LUSC trans rs3733585 0.673 rs4312757 chr4:9956145 T/A cg26043149 chr18:55253948 FECH -0.45 -7.02 -0.36 1.23e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg24675056 chr1:15929824 NA 0.45 7.65 0.39 2.12e-13 Systolic blood pressure; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg02370978 chr2:86333167 PTCD3;POLR1A 0.42 5.98 0.31 5.67e-9 Mosquito bite size; LUSC cis rs8060686 0.641 rs7188085 chr16:68113873 A/G cg27539214 chr16:67997921 SLC12A4 -0.55 -7.55 -0.38 4.25e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9300255 0.602 rs1727316 chr12:123618603 C/T cg05973401 chr12:123451056 ABCB9 0.54 6.77 0.35 5.67e-11 Neutrophil percentage of white cells; LUSC cis rs1358748 0.555 rs2093331 chr1:67531967 G/C cg02640540 chr1:67518911 SLC35D1 0.62 6.52 0.34 2.6e-10 Tuberculosis; LUSC cis rs12950390 0.814 rs11659069 chr17:45834275 G/T cg03474202 chr17:45855739 NA -0.29 -6.48 -0.33 3.26e-10 IgG glycosylation; LUSC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg25204440 chr1:209979598 IRF6 0.47 5.94 0.31 7.17e-9 Cleft lip with or without cleft palate; LUSC cis rs7523050 0.643 rs7551142 chr1:109399710 G/T cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC cis rs6696846 0.765 rs11576867 chr1:205064676 C/T cg03948781 chr1:205179583 DSTYK 0.32 6.25 0.32 1.26e-9 Red blood cell count; LUSC cis rs7923609 0.871 rs6479905 chr10:65315231 A/G cg01631684 chr10:65280961 REEP3 0.41 6.05 0.31 3.84e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs2648875 1.000 rs1472483 chr8:129070781 G/T cg14550066 chr19:55417500 NCR1 0.34 6.03 0.31 4.46e-9 End-stage renal disease; LUSC cis rs9457247 0.602 rs10484530 chr6:167461562 C/T cg25258033 chr6:167368657 RNASET2 0.44 6.61 0.34 1.53e-10 Crohn's disease; LUSC cis rs2717559 0.561 rs7841267 chr8:143881683 A/C cg02415014 chr8:143852576 LYNX1 0.33 7.66 0.39 1.97e-13 Urinary tract infection frequency; LUSC cis rs72781680 0.898 rs17462433 chr2:24012758 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs11155671 0.530 rs7756850 chr6:150212596 G/C cg13206674 chr6:150067644 NUP43 0.43 6.48 0.33 3.26e-10 Testicular germ cell tumor; LUSC cis rs1950626 0.623 rs3742401 chr14:101453344 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.44 0.38 8.78e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.35 -0.37 1.51e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg19717773 chr7:2847554 GNA12 -0.38 -5.99 -0.31 5.34e-9 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11223367 chr3:101497980 FAM55C -0.44 -6.39 -0.33 5.65e-10 Electrocardiographic conduction measures; LUSC cis rs6496044 0.568 rs6496039 chr15:86061963 A/T cg13263323 chr15:86062960 AKAP13 -0.38 -6.23 -0.32 1.39e-9 Interstitial lung disease; LUSC cis rs722599 0.748 rs731165 chr14:75352555 T/C cg08847533 chr14:75593920 NEK9 -0.48 -6.88 -0.35 3e-11 IgG glycosylation; LUSC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -7.24 -0.37 3.11e-12 Developmental language disorder (linguistic errors); LUSC cis rs6495122 0.532 rs2472304 chr15:75044238 G/A cg14664628 chr15:75095509 CSK -0.67 -10.27 -0.49 1.14e-21 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC trans rs7786808 0.741 rs11769149 chr7:158227127 A/G cg02030672 chr11:45687055 CHST1 -0.42 -6.33 -0.33 7.7e-10 Obesity-related traits; LUSC trans rs747782 0.528 rs11039669 chr11:48328818 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.34 9.17e-11 Intraocular pressure; LUSC cis rs981844 0.740 rs10009844 chr4:154681576 C/T cg14289246 chr4:154710475 SFRP2 -0.49 -6.97 -0.36 1.73e-11 Response to statins (LDL cholesterol change); LUSC trans rs961253 0.522 rs2225115 chr20:6360465 C/T cg21095983 chr6:86352623 SYNCRIP 0.49 7.2 0.37 4.09e-12 Colorectal cancer; LUSC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg25319279 chr11:5960081 NA -0.45 -7.03 -0.36 1.18e-11 DNA methylation (variation); LUSC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg06221963 chr1:154839813 KCNN3 -0.6 -13.05 -0.58 9.49e-32 Prostate cancer; LUSC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.11 0.32 2.74e-9 Personality dimensions; LUSC cis rs8046696 1 rs8046696 chr16:75442143 T/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.48 -0.33 3.37e-10 Coronary artery disease; LUSC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg05313129 chr8:58192883 C8orf71 -0.53 -6.85 -0.35 3.6e-11 Developmental language disorder (linguistic errors); LUSC cis rs2197308 0.740 rs11182251 chr12:37919611 C/T cg26384229 chr12:38710491 ALG10B -0.81 -13.47 -0.59 2.57e-33 Morning vs. evening chronotype; LUSC cis rs71403859 0.502 rs71403847 chr16:71468226 T/C cg08717414 chr16:71523259 ZNF19 -0.69 -7.92 -0.4 3.65e-14 Post bronchodilator FEV1; LUSC cis rs6665290 0.835 rs7549465 chr1:227214399 A/C cg10327440 chr1:227177885 CDC42BPA -1.22 -39.35 -0.91 1.8e-127 Myeloid white cell count; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg00047844 chr17:77752442 CBX2 0.56 7.54 0.38 4.52e-13 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9581857 0.547 rs9581871 chr13:28085767 G/A cg22138327 chr13:27999177 GTF3A 0.69 7.14 0.36 5.86e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.53 -7.97 -0.4 2.52e-14 Lymphocyte counts; LUSC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg18681998 chr4:17616180 MED28 0.83 15.06 0.64 1.76e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg16606324 chr3:10149918 C3orf24 0.67 9.74 0.47 6.66e-20 Alzheimer's disease; LUSC cis rs1775715 0.870 rs1755084 chr10:32253709 C/T cg26784012 chr10:32216390 ARHGAP12 0.41 6.5 0.33 3.01e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs740160 0.510 rs6958704 chr7:98898358 G/A cg24650262 chr7:98904301 NA 0.62 6.9 0.35 2.68e-11 Dehydroepiandrosterone sulphate levels; LUSC cis rs67072384 0.901 rs7936972 chr11:72479692 T/C cg04827223 chr11:72435913 ARAP1 -0.87 -6.44 -0.33 4.27e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg07701084 chr6:150067640 NUP43 0.57 8.93 0.44 2.83e-17 Lung cancer; LUSC trans rs11098499 0.863 rs13134665 chr4:120426430 T/C cg25214090 chr10:38739885 LOC399744 0.5 7.4 0.38 1.11e-12 Corneal astigmatism; LUSC cis rs9463078 0.764 rs9367211 chr6:44885305 T/C cg25276700 chr6:44698697 NA -0.3 -6.08 -0.32 3.32e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs8072100 0.840 rs9895746 chr17:45479099 C/A cg04995722 chr7:26192034 NFE2L3 -0.39 -6.33 -0.33 7.75e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12541635 0.677 rs10808408 chr8:107005034 C/T cg10147462 chr8:107024639 NA 0.65 13.57 0.6 1.06e-33 Age of smoking initiation; LUSC cis rs11583043 0.874 rs41312668 chr1:101443582 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.28 0.32 1.08e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs6445975 0.578 rs6782218 chr3:58408765 T/C cg18950693 chr14:70346909 SMOC1 -0.39 -5.96 -0.31 6.27e-9 Systemic lupus erythematosus; LUSC cis rs1712517 1.000 rs1712517 chr10:105033015 C/T cg05636881 chr10:105038444 INA 0.39 6.61 0.34 1.51e-10 Migraine; LUSC cis rs6835098 0.961 rs11737748 chr4:174130503 T/C cg08422745 chr4:174089978 GALNT7 0.81 13.18 0.58 3.16e-32 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg15839431 chr19:19639596 YJEFN3 -0.63 -7.11 -0.36 7.15e-12 Bipolar disorder; LUSC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg06634786 chr22:41940651 POLR3H -0.53 -6.43 -0.33 4.33e-10 Vitiligo; LUSC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg15744005 chr10:104629667 AS3MT -0.29 -6.25 -0.32 1.22e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs909341 0.716 rs71325463 chr20:62362834 G/A cg09650180 chr20:62225654 GMEB2 -0.45 -5.85 -0.31 1.14e-8 Atopic dermatitis; LUSC cis rs4285028 1.000 rs4285028 chr3:121660664 A/C cg11130432 chr3:121712080 ILDR1 -0.63 -9.81 -0.47 4.04e-20 Multiple sclerosis; LUSC trans rs17086172 0.630 rs1432076 chr18:70273041 G/A cg02919422 chr8:55370544 SOX17 -0.59 -6.12 -0.32 2.69e-9 Airflow obstruction; LUSC cis rs5758659 0.714 rs5758578 chr22:42490292 A/C cg15557168 chr22:42548783 NA 0.35 5.82 0.3 1.36e-8 Cognitive function; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg06145435 chr7:1022769 CYP2W1 0.28 6.12 0.32 2.55e-9 Longevity;Endometriosis; LUSC cis rs427941 0.967 rs6970036 chr7:101841824 A/G cg06246474 chr7:101738831 CUX1 0.35 5.65 0.3 3.37e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs62400317 0.826 rs11970412 chr6:45037516 C/T cg20913747 chr6:44695427 NA -0.46 -7.42 -0.38 9.73e-13 Total body bone mineral density; LUSC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.63 -14.03 -0.61 1.75e-35 Hemoglobin concentration; LUSC cis rs1023500 0.596 rs5751209 chr22:42451603 A/G cg15557168 chr22:42548783 NA -0.41 -6.18 -0.32 1.88e-9 Schizophrenia; LUSC cis rs7267979 0.933 rs2387887 chr20:25427081 G/T cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.51 7.87 0.4 5.03e-14 Depressive symptoms; LUSC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg20503657 chr10:835505 NA 1.0 13.9 0.61 5.86e-35 Eosinophil percentage of granulocytes; LUSC cis rs9300255 0.596 rs11057202 chr12:123720775 G/T cg05973401 chr12:123451056 ABCB9 0.51 7.06 0.36 9.93e-12 Neutrophil percentage of white cells; LUSC cis rs72634258 0.503 rs72632055 chr1:7835774 T/G cg26816564 chr1:7831052 VAMP3 1.04 14.18 0.61 4.77e-36 Inflammatory bowel disease; LUSC cis rs7927592 0.913 rs7104345 chr11:68316772 G/A cg01657329 chr11:68192670 LRP5 -0.39 -5.67 -0.3 3.17e-8 Total body bone mineral density; LUSC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg00745463 chr17:30367425 LRRC37B 0.79 8.96 0.44 2.27e-17 Hip circumference adjusted for BMI; LUSC cis rs12791968 0.765 rs11038250 chr11:45009114 A/G cg11846598 chr11:44996168 LOC221122 -0.56 -7.78 -0.39 9.2e-14 Inhibitory control; LUSC cis rs6489882 0.867 rs4766674 chr12:113365201 A/C cg20102336 chr12:113376681 OAS3 0.43 6.22 0.32 1.51e-9 Chronic lymphocytic leukemia; LUSC cis rs2806561 0.765 rs652783 chr1:23514313 G/T cg12483005 chr1:23474871 LUZP1 0.42 6.62 0.34 1.4e-10 Height; LUSC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg00990874 chr7:1149470 C7orf50 -0.53 -6.87 -0.35 3.09e-11 Bronchopulmonary dysplasia; LUSC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg03264133 chr6:25882463 NA 0.63 10.68 0.5 4.18e-23 Blood metabolite levels; LUSC cis rs936229 0.813 rs1378938 chr15:75096443 T/C cg10253484 chr15:75165896 SCAMP2 -0.51 -6.82 -0.35 4.4e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs60843830 0.508 rs300750 chr2:208794 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.42 6.65 0.34 1.18e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs8113142 0.651 rs73026091 chr19:29107018 T/C cg04546413 chr19:29218101 NA 0.42 5.76 0.3 1.96e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs8032315 1.000 rs8032315 chr15:91418297 A/T cg06330618 chr15:91428456 FES 0.28 5.8 0.3 1.51e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg08392591 chr16:89556376 ANKRD11 0.47 7.19 0.37 4.28e-12 Multiple myeloma (IgH translocation); LUSC cis rs10751667 0.925 rs7115336 chr11:988101 C/G ch.11.42038R chr11:967971 AP2A2 0.54 7.86 0.4 5.22e-14 Alzheimer's disease (late onset); LUSC cis rs11105298 0.891 rs12369195 chr12:89934972 G/C cg00757033 chr12:89920650 WDR51B 0.61 10.88 0.51 8.3e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg04553112 chr3:125709451 NA -0.47 -5.69 -0.3 2.76e-8 Blood pressure (smoking interaction); LUSC cis rs34779708 0.897 rs16935880 chr10:35415468 C/G cg03585969 chr10:35415529 CREM 0.61 8.92 0.44 3.24e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6918586 0.658 rs198809 chr6:26128766 G/A cg17691542 chr6:26056736 HIST1H1C 0.4 5.97 0.31 5.97e-9 Schizophrenia; LUSC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg23248424 chr5:179741104 GFPT2 -0.57 -8.97 -0.44 2.12e-17 Height; LUSC trans rs7615952 0.599 rs6438953 chr3:125724951 T/C cg07211511 chr3:129823064 LOC729375 -0.83 -11.86 -0.54 2.64e-27 Blood pressure (smoking interaction); LUSC cis rs67311347 0.605 rs1880762 chr3:40283215 A/G cg02782426 chr3:40428986 ENTPD3 0.33 5.94 0.31 7e-9 Renal cell carcinoma; LUSC cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg23711669 chr6:146136114 FBXO30 0.71 12.32 0.56 5.36e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.29e-12 Developmental language disorder (linguistic errors); LUSC cis rs4820539 1.000 rs4822361 chr22:23482718 A/G cg14186256 chr22:23484241 RTDR1 -0.93 -17.64 -0.69 1.13e-49 Bone mineral density; LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg10729496 chr3:10149963 C3orf24 0.52 6.88 0.35 2.9100000000000002e-11 Alzheimer's disease; LUSC trans rs12439619 0.508 rs8032033 chr15:82457896 G/C cg04831495 chr15:85060580 GOLGA6L5 -0.48 -7.84 -0.39 6.29e-14 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs11098499 0.954 rs4577559 chr4:120404043 T/G cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.57e-25 Corneal astigmatism; LUSC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs4737010 0.501 rs55694640 chr8:41649439 T/G cg17182837 chr8:41585554 ANK1 -0.39 -6.91 -0.35 2.44e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg26384229 chr12:38710491 ALG10B -0.82 -14.09 -0.61 1.03e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs7180079 0.925 rs4776447 chr15:64643067 C/T cg08069370 chr15:64387884 SNX1 0.54 5.91 0.31 8.34e-9 Monocyte count; LUSC cis rs12368653 0.666 rs799265 chr12:58112189 A/G cg12615879 chr12:58013172 SLC26A10 0.37 8.55 0.42 4.47e-16 Multiple sclerosis; LUSC cis rs614226 0.935 rs17431717 chr12:120912210 G/A cg21053147 chr12:120880522 NA 0.55 6.62 0.34 1.41e-10 Type 1 diabetes nephropathy; LUSC trans rs1493916 0.905 rs1586988 chr18:31396001 G/C cg15819921 chr19:927150 ARID3A -0.44 -6.54 -0.34 2.29e-10 Life satisfaction; LUSC cis rs2294693 0.945 rs10947944 chr6:41004657 T/C cg14769373 chr6:40998127 UNC5CL -0.52 -6.93 -0.35 2.12e-11 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg03146154 chr1:46216737 IPP -0.54 -8.3 -0.41 2.65e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs72634258 0.554 rs34020118 chr1:7895015 C/T cg26816564 chr1:7831052 VAMP3 0.96 13.23 0.59 1.99e-32 Inflammatory bowel disease; LUSC cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg20503657 chr10:835505 NA 0.89 12.3 0.56 6.15e-29 Eosinophil percentage of granulocytes; LUSC cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg15105969 chr2:36825350 FEZ2 0.45 5.91 0.31 8.56e-9 Height; LUSC cis rs4332037 0.901 rs7791299 chr7:1935598 T/C cg23422044 chr7:1970798 MAD1L1 -0.6 -7.22 -0.37 3.44e-12 Bipolar disorder; LUSC cis rs61931739 0.963 rs1817759 chr12:34101521 G/A cg06521331 chr12:34319734 NA 0.4 6.56 0.34 2.11e-10 Morning vs. evening chronotype; LUSC cis rs193541 0.545 rs12518979 chr5:122181787 G/T cg19077854 chr5:122220652 SNX24 -0.35 -7.47 -0.38 7.17e-13 Glucose homeostasis traits; LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.8 -0.65 2.29e-42 Gut microbiome composition (summer); LUSC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.44 -0.33 4.08e-10 Alzheimer's disease (late onset); LUSC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.7 -0.34 9.06e-11 Lung cancer; LUSC cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg04586622 chr2:25135609 ADCY3 0.42 9.0 0.44 1.8e-17 Body mass index; LUSC cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg26384229 chr12:38710491 ALG10B 0.91 15.38 0.64 9.57e-41 Bladder cancer; LUSC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.15 16.22 0.66 4.64e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg07701084 chr6:150067640 NUP43 0.57 8.84 0.44 5.56e-17 Lung cancer; LUSC cis rs56283067 0.887 rs7765371 chr6:44777204 G/A cg18551225 chr6:44695536 NA -0.47 -7.3 -0.37 2.18e-12 Total body bone mineral density; LUSC cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg01579765 chr21:45077557 HSF2BP 0.47 9.4 0.46 9.14e-19 Mean corpuscular volume; LUSC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg10295955 chr4:187884368 NA -1.07 -24.87 -0.81 5.49e-78 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC trans rs9926296 0.712 rs2434872 chr16:89716915 C/G cg13698153 chr12:118541722 VSIG10 -0.35 -5.96 -0.31 6.28e-9 Vitiligo; LUSC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.45 -7.51 -0.38 5.46e-13 Bipolar disorder; LUSC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg07936489 chr17:37558343 FBXL20 -0.68 -9.56 -0.46 2.75e-19 Glomerular filtration rate (creatinine); LUSC cis rs208520 1.000 rs72884033 chr6:66995747 T/C cg07460842 chr6:66804631 NA 0.93 12.09 0.55 3.65e-28 Exhaled nitric oxide output; LUSC cis rs965513 1.000 rs7847663 chr9:100544868 C/T cg13688889 chr9:100608707 NA -0.56 -8.45 -0.42 9.41e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg15649852 chr7:65879115 NA -0.41 -5.83 -0.3 1.31e-8 Aortic root size; LUSC cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg18252515 chr7:66147081 NA -1.18 -13.0 -0.58 1.52e-31 Diabetic kidney disease; LUSC cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.32 0.37 1.82e-12 Motion sickness; LUSC cis rs8099014 0.911 rs8092394 chr18:56127755 A/T cg12907477 chr18:56117327 MIR122 0.43 6.69 0.34 9.48e-11 Platelet count; LUSC cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg26647111 chr11:31128758 NA -0.41 -5.98 -0.31 5.75e-9 Red blood cell count; LUSC trans rs11098499 0.954 rs10017543 chr4:120321420 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.22 0.32 1.49e-9 Corneal astigmatism; LUSC cis rs8141797 0.748 rs3788368 chr22:24577986 T/C cg00411358 chr22:24577142 SUSD2 -0.5 -5.84 -0.3 1.23e-8 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.45 0.33 3.95e-10 Coronary artery disease; LUSC cis rs13418410 0.715 rs7571269 chr2:33797271 C/A cg04131969 chr2:33951647 MYADML -0.46 -6.1 -0.32 2.9e-9 Non-response to antidepressants and depression; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg08677398 chr8:58056175 NA 0.54 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); LUSC cis rs12760731 0.565 rs7536856 chr1:178057927 A/G cg00404053 chr1:178313656 RASAL2 0.69 6.77 0.35 5.79e-11 Obesity-related traits; LUSC cis rs2295359 1.000 rs11465753 chr1:67631423 T/C cg17031739 chr1:67600172 NA 0.37 5.71 0.3 2.5e-8 Psoriasis; LUSC trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg27661571 chr11:113659931 NA -0.61 -7.31 -0.37 1.96e-12 Hip circumference adjusted for BMI; LUSC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.97 -0.36 1.74e-11 Intelligence (multi-trait analysis); LUSC cis rs12594515 1.000 rs12595137 chr15:45986105 G/T cg06207120 chr15:45996521 NA 0.39 5.9 0.31 8.8e-9 Waist circumference;Weight; LUSC cis rs11098499 0.908 rs7696649 chr4:120322177 G/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs12681287 0.752 rs12675974 chr8:87247845 T/C cg27223183 chr8:87520930 FAM82B -0.45 -5.72 -0.3 2.35e-8 Caudate activity during reward; LUSC cis rs977987 0.737 rs8046697 chr16:75442144 T/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.48 -0.33 3.37e-10 Dupuytren's disease; LUSC cis rs7833986 0.501 rs72651502 chr8:56875533 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.64 9.92 0.48 1.7e-20 Height; LUSC cis rs8114671 0.804 rs3803936 chr20:33632775 T/C cg24642439 chr20:33292090 TP53INP2 -0.4 -5.76 -0.3 1.92e-8 Height; LUSC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg07424592 chr7:64974309 NA 0.69 6.08 0.32 3.28e-9 Diabetic kidney disease; LUSC cis rs9653442 0.545 rs13415465 chr2:100764004 T/G cg07810366 chr2:100720526 AFF3 -0.46 -7.79 -0.39 8.33e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg12219531 chr12:120966889 COQ5 0.6 8.1 0.41 1.02e-14 High light scatter reticulocyte count; LUSC cis rs28453840 1 rs28453840 chr2:136522941 G/A cg07169764 chr2:136633963 MCM6 -0.59 -7.76 -0.39 1.05e-13 Cholesterol, total; LUSC cis rs10193935 0.901 rs13429697 chr2:42529818 C/T cg27598129 chr2:42591480 NA -0.61 -8.32 -0.41 2.25e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg26408565 chr15:76604113 ETFA -0.48 -7.67 -0.39 1.84e-13 Blood metabolite levels; LUSC cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -7.63 -0.39 2.54e-13 Schizophrenia; LUSC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.71 -0.43 1.43e-16 Bipolar disorder; LUSC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg11764359 chr7:65958608 NA 0.71 10.69 0.5 3.95e-23 Aortic root size; LUSC cis rs9807989 0.524 rs6759479 chr2:103040047 A/C cg03938978 chr2:103052716 IL18RAP 0.37 7.07 0.36 9.39e-12 Asthma; LUSC cis rs2734839 0.537 rs10891549 chr11:113278447 T/C cg14159747 chr11:113255604 NA 0.27 7.12 0.36 6.67e-12 Information processing speed; LUSC cis rs9457247 0.565 rs2038580 chr6:167456490 A/T cg06454157 chr6:167490870 NA -0.29 -6.79 -0.35 5.15e-11 Crohn's disease; LUSC cis rs7659604 0.935 rs73844280 chr4:122664687 G/A cg06713675 chr4:122721982 EXOSC9 -0.45 -8.02 -0.4 1.86e-14 Type 2 diabetes; LUSC cis rs1775715 0.737 rs2808072 chr10:32205504 A/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.59e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -7.49 -0.38 6.09e-13 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg21724239 chr8:58056113 NA 0.88 9.73 0.47 7.33e-20 Developmental language disorder (linguistic errors); LUSC cis rs9928842 0.824 rs12924999 chr16:75262425 T/G cg09066997 chr16:75300724 BCAR1 0.52 6.39 0.33 5.5e-10 Alcoholic chronic pancreatitis; LUSC trans rs61931739 0.534 rs1211286 chr12:34135581 T/C cg13010199 chr12:38710504 ALG10B 0.52 7.89 0.4 4.32e-14 Morning vs. evening chronotype; LUSC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs4076764 0.801 rs12046142 chr1:163375247 G/A cg06092702 chr1:163392909 NA -0.39 -6.55 -0.34 2.21e-10 Motion sickness; LUSC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.43 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg08280861 chr8:58055591 NA 0.55 6.51 0.34 2.73e-10 Developmental language disorder (linguistic errors); LUSC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.41 7.96 0.4 2.71e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs2070488 0.965 rs7373828 chr3:38524311 A/G cg24069376 chr3:38537580 EXOG 0.51 10.51 0.5 1.63e-22 Electrocardiographic conduction measures; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11226328 chr1:29213367 EPB41 0.44 6.35 0.33 6.99e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs453301 0.686 rs11785634 chr8:8892597 G/T cg15556689 chr8:8085844 FLJ10661 -0.62 -10.05 -0.48 6.09e-21 Joint mobility (Beighton score); LUSC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg21724239 chr8:58056113 NA 0.59 7.31 0.37 1.97e-12 Developmental language disorder (linguistic errors); LUSC cis rs28374715 0.662 rs28493087 chr15:41486504 G/A cg18705301 chr15:41695430 NDUFAF1 -0.86 -15.28 -0.64 2.37e-40 Ulcerative colitis; LUSC cis rs4595586 0.545 rs2218762 chr12:39397762 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs7503807 0.905 rs9909449 chr17:78614393 A/G cg09596252 chr17:78655493 RPTOR 0.44 7.53 0.38 4.77e-13 Obesity; LUSC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.73 0.35 7.58e-11 Tonsillectomy; LUSC cis rs3790645 0.958 rs2278979 chr1:26877708 G/A cg17456097 chr1:26900765 RPS6KA1 0.46 6.7 0.34 8.87e-11 Glucose homeostasis traits; LUSC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg09975044 chr14:104007538 NA 0.36 5.7 0.3 2.58e-8 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg17554472 chr22:41940697 POLR3H -0.45 -5.76 -0.3 1.86e-8 Vitiligo; LUSC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg09509183 chr1:209979624 IRF6 0.53 6.29 0.33 9.68e-10 Cleft lip with or without cleft palate; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg11141652 chr22:24348549 GSTTP1 0.39 5.83 0.3 1.29e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg20243544 chr17:37824526 PNMT 0.4 6.03 0.31 4.26e-9 Self-reported allergy; LUSC trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg15704280 chr7:45808275 SEPT13 0.67 7.36 0.37 1.46e-12 Axial length; LUSC cis rs9309473 1.000 rs10190219 chr2:73658331 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.46 -0.33 3.62e-10 Metabolite levels; LUSC trans rs9650657 0.740 rs6980805 chr8:10679842 G/C cg15556689 chr8:8085844 FLJ10661 -0.4 -6.07 -0.32 3.56e-9 Neuroticism; LUSC cis rs2115630 1.000 rs11854291 chr15:85363708 T/C cg09876464 chr15:85330779 ZNF592 0.36 6.67 0.34 1.07e-10 P wave terminal force; LUSC cis rs9457247 0.967 rs428805 chr6:167403132 C/A cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC trans rs12080794 1.000 rs12239637 chr1:9155711 C/T cg11315153 chr6:62996299 KHDRBS2 -0.52 -6.11 -0.32 2.76e-9 Response to antidepressant treatment (citalopram); LUSC cis rs34375054 0.624 rs12832525 chr12:125680366 T/C cg06287003 chr12:125626642 AACS -0.36 -5.7 -0.3 2.6e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg23711669 chr6:146136114 FBXO30 -0.83 -15.28 -0.64 2.37e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs295140 0.506 rs4673855 chr2:201136143 A/G cg23649088 chr2:200775458 C2orf69 -0.37 -5.69 -0.3 2.72e-8 QT interval; LUSC cis rs4588572 0.686 rs67689570 chr5:77676843 T/C cg11547950 chr5:77652471 NA 0.54 7.76 0.39 1.04e-13 Triglycerides; LUSC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.76e-13 Schizophrenia; LUSC cis rs2282300 0.956 rs1222212 chr11:30374643 C/T cg25418670 chr11:30344373 C11orf46 -0.53 -7.39 -0.37 1.19e-12 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15539901 chr8:124084814 WDR67 0.5 7.34 0.37 1.6e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs11992162 0.591 rs34123222 chr8:11795349 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.86 -0.35 3.36e-11 Monocyte count; LUSC cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg01256987 chr12:42539512 GXYLT1 -0.44 -8.5 -0.42 6.62e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg26677194 chr12:130822605 PIWIL1 0.6 8.96 0.44 2.29e-17 Menopause (age at onset); LUSC cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg06636001 chr8:8085503 FLJ10661 0.57 8.4 0.42 1.28e-15 Mood instability; LUSC cis rs6754311 0.593 rs4954279 chr2:136409073 G/A cg07169764 chr2:136633963 MCM6 0.55 7.25 0.37 2.94e-12 Mosquito bite size; LUSC cis rs9341808 0.667 rs583426 chr6:80946687 G/A cg08355045 chr6:80787529 NA -0.4 -6.82 -0.35 4.37e-11 Sitting height ratio; LUSC cis rs2354432 0.607 rs6689243 chr1:146710559 A/T cg25205988 chr1:146714368 CHD1L -1.01 -9.27 -0.45 2.33e-18 Mitochondrial DNA levels; LUSC cis rs2885056 0.783 rs73007347 chr19:10650649 C/T cg06392426 chr19:10676186 KRI1 0.48 5.78 0.3 1.74e-8 Red cell distribution width; LUSC trans rs61931739 0.517 rs11052980 chr12:34036036 T/C cg13010199 chr12:38710504 ALG10B 0.52 7.89 0.4 4.44e-14 Morning vs. evening chronotype; LUSC cis rs9300255 0.722 rs10773008 chr12:123800820 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -5.77 -0.3 1.85e-8 Neutrophil percentage of white cells; LUSC cis rs4363385 0.588 rs12079087 chr1:153023888 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.8 -0.3 1.54e-8 Inflammatory skin disease; LUSC trans rs1997103 0.871 rs6956733 chr7:55393032 A/C cg20935933 chr6:143382018 AIG1 0.45 6.06 0.31 3.62e-9 QRS interval (sulfonylurea treatment interaction); LUSC cis rs422249 0.634 rs174615 chr11:61628964 T/A cg06860612 chr11:61641270 FADS3 0.28 5.86 0.31 1.09e-8 Trans fatty acid levels; LUSC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg17261708 chr5:176794207 RGS14 -0.36 -6.07 -0.32 3.5e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs6964587 0.839 rs17731846 chr7:91440342 A/G cg17063962 chr7:91808500 NA 0.59 9.15 0.45 5.84e-18 Breast cancer; LUSC cis rs8062405 0.737 rs11861132 chr16:28871860 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg08847533 chr14:75593920 NEK9 -0.83 -15.44 -0.65 5.91e-41 Height; LUSC cis rs73200209 0.744 rs17426718 chr12:116599676 A/C cg01776926 chr12:116560359 MED13L -0.51 -6.12 -0.32 2.68e-9 Total body bone mineral density; LUSC cis rs977987 0.742 rs12928898 chr16:75462081 G/A cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs4964805 1.000 rs73192052 chr12:104190854 C/T cg02344784 chr12:104178138 NT5DC3 0.43 6.71 0.34 8.11e-11 Attention deficit hyperactivity disorder; LUSC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg12463550 chr7:65579703 CRCP -0.49 -7.38 -0.37 1.29e-12 Aortic root size; LUSC cis rs6847149 1.000 rs6847149 chr4:110800097 C/T cg07850274 chr4:110748770 RRH -0.57 -8.02 -0.4 1.84e-14 Exercise treadmill test traits; LUSC cis rs12530845 0.943 rs60858457 chr7:135336918 T/C cg23117316 chr7:135346802 PL-5283 -0.57 -9.06 -0.44 1.1e-17 Red blood cell traits; LUSC cis rs11674184 0.564 rs746579 chr2:11744694 C/T cg07314298 chr2:11723111 GREB1 -0.63 -10.07 -0.48 5.2e-21 Endometriosis; LUSC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg02487422 chr3:49467188 NICN1 0.44 7.04 0.36 1.12e-11 Resting heart rate; LUSC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.63 -5.9 -0.31 8.74e-9 Cerebrospinal P-tau181p levels; LUSC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg18252515 chr7:66147081 NA 1.23 14.1 0.61 9.75e-36 Diabetic kidney disease; LUSC cis rs950169 0.922 rs11633075 chr15:85113972 C/A cg17173187 chr15:85201210 NMB 0.35 6.28 0.32 1.07e-9 Schizophrenia; LUSC cis rs921968 0.613 rs6436066 chr2:219578361 T/G cg02176678 chr2:219576539 TTLL4 -0.6 -10.7 -0.51 3.66e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs7312933 0.501 rs3810793 chr12:42729407 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.77 0.35 5.63e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9388451 0.839 rs10457469 chr6:126083658 G/A cg05901451 chr6:126070800 HEY2 -0.96 -19.24 -0.73 4.75e-56 Brugada syndrome; LUSC trans rs1459104 0.759 rs7939392 chr11:55257285 C/T cg03929089 chr4:120376271 NA 0.58 6.12 0.32 2.63e-9 Body mass index; LUSC cis rs10779751 0.770 rs11121695 chr1:11229515 G/A cg08854313 chr1:11322531 MTOR -0.83 -12.58 -0.57 5.67e-30 Body mass index; LUSC cis rs4077468 1.000 rs9661504 chr1:205915667 A/T cg11965913 chr1:205819406 PM20D1 -0.39 -5.74 -0.3 2.1e-8 Cystic fibrosis-related diabetes; LUSC cis rs77741769 0.571 rs1542859 chr12:121336766 A/G cg02419362 chr12:121203948 SPPL3 0.46 8.44 0.42 9.89e-16 Mean corpuscular volume; LUSC cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg26384229 chr12:38710491 ALG10B 0.87 14.76 0.63 2.57e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs763121 0.853 rs6519119 chr22:38989007 C/G cg14440974 chr22:39074834 NA -0.36 -6.05 -0.31 3.83e-9 Menopause (age at onset); LUSC cis rs4674676 1 rs4674676 chr2:223529112 A/G cg25565276 chr2:223520875 FARSB 1.1 15.63 0.65 1.05e-41 Chin dimples; LUSC cis rs1595825 0.891 rs7584475 chr2:198577424 A/C cg00982548 chr2:198649783 BOLL -0.5 -6.45 -0.33 3.93e-10 Ulcerative colitis; LUSC cis rs698813 0.543 rs12468824 chr2:44482448 G/T cg00619915 chr2:44497795 NA -0.53 -7.52 -0.38 5e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs1358748 0.522 rs2092911 chr1:67574319 T/G cg02640540 chr1:67518911 SLC35D1 0.62 6.06 0.31 3.71e-9 Tuberculosis; LUSC cis rs713587 0.935 rs4430895 chr2:25161386 C/T cg15423357 chr2:25149977 NA 0.42 8.35 0.42 1.89e-15 Body mass index in non-asthmatics; LUSC cis rs7192380 0.964 rs11075729 chr16:69620278 G/A cg26679644 chr16:69762563 NA 0.36 6.39 0.33 5.66e-10 Sjögren's syndrome; LUSC cis rs2777491 0.957 rs3743038 chr15:41694743 C/T cg18705301 chr15:41695430 NDUFAF1 -0.73 -13.71 -0.6 3.05e-34 Ulcerative colitis; LUSC cis rs2562456 0.833 rs62110428 chr19:21613656 C/T cg00806126 chr19:22604979 ZNF98 -0.4 -5.71 -0.3 2.53e-8 Pain; LUSC trans rs2983496 1.000 rs12525763 chr6:166037281 C/T cg20192747 chr18:44774846 NA -0.46 -5.95 -0.31 6.79e-9 Cortisol levels (saliva); LUSC cis rs73058052 1.000 rs2288920 chr19:50091798 G/T cg09250473 chr19:50168907 IRF3;BCL2L12 0.53 6.07 0.32 3.43e-9 Fibrinogen levels; LUSC cis rs9457247 0.561 rs916331 chr6:167470559 T/G cg06454157 chr6:167490870 NA -0.29 -6.78 -0.35 5.52e-11 Crohn's disease; LUSC trans rs853679 0.546 rs34194357 chr6:27818535 A/G cg01620082 chr3:125678407 NA -0.82 -7.32 -0.37 1.84e-12 Depression; LUSC cis rs12681287 0.547 rs6985066 chr8:87526439 A/C cg27223183 chr8:87520930 FAM82B -0.54 -7.15 -0.36 5.67e-12 Caudate activity during reward; LUSC cis rs7945718 0.967 rs4415740 chr11:12783911 C/T cg25843174 chr11:12811716 TEAD1 0.32 7.15 0.36 5.54e-12 Educational attainment (years of education); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg25734572 chr19:9896597 NA 0.39 6.48 0.33 3.27e-10 Schizophrenia; LUSC cis rs7647973 1.000 rs7619789 chr3:49476263 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.52 0.38 5.17e-13 Menarche (age at onset); LUSC cis rs654950 0.875 rs632166 chr1:41995681 T/C cg06885757 chr1:42089581 HIVEP3 -0.33 -6.34 -0.33 7.57e-10 Airway imaging phenotypes; LUSC cis rs2637266 0.875 rs12783253 chr10:78378108 A/G cg18941641 chr10:78392320 NA 0.39 7.03 0.36 1.14e-11 Pulmonary function; LUSC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.51 0.34 2.73e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg26395211 chr5:140044315 WDR55 0.45 7.08 0.36 8.31e-12 Depressive symptoms (multi-trait analysis); LUSC trans rs1005277 0.579 rs2505194 chr10:38393881 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.43 -0.46 6.9e-19 Extrinsic epigenetic age acceleration; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05533744 chr16:67226368 E2F4 0.4 5.99 0.31 5.43e-9 Asthma; LUSC cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg21535247 chr6:8435926 SLC35B3 0.57 8.67 0.43 1.96e-16 Motion sickness; LUSC cis rs858239 0.539 rs10280815 chr7:23188370 A/C cg23682824 chr7:23144976 KLHL7 0.4 5.71 0.3 2.52e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs4820539 1.000 rs5759595 chr22:23471624 G/A cg21100191 chr22:23484243 RTDR1 0.92 16.16 0.66 8.64e-44 Bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12732805 chr8:146078479 COMMD5 -0.43 -6.31 -0.33 8.88e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs394563 0.781 rs61516098 chr6:149794289 A/T cg03678062 chr6:149772716 ZC3H12D -0.3 -6.15 -0.32 2.24e-9 Dupuytren's disease; LUSC cis rs2637266 1.000 rs2395410 chr10:78381767 C/T cg18941641 chr10:78392320 NA 0.39 7.16 0.36 5.33e-12 Pulmonary function; LUSC cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg22782873 chr19:19639568 YJEFN3 0.49 6.16 0.32 2.05e-9 Bipolar disorder; LUSC cis rs11122272 0.668 rs2808616 chr1:231554993 C/G cg06096015 chr1:231504339 EGLN1 -0.48 -8.28 -0.41 2.96e-15 Hemoglobin concentration; LUSC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg20849893 chr7:64541193 NA -0.65 -5.68 -0.3 2.99e-8 Diabetic kidney disease; LUSC cis rs3857536 0.813 rs6455091 chr6:66949127 C/G cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs1595825 0.891 rs73056877 chr2:198816724 A/C cg00982548 chr2:198649783 BOLL -0.58 -7.2 -0.37 4.13e-12 Ulcerative colitis; LUSC cis rs2109514 0.870 rs6976316 chr7:116122943 G/A cg12739419 chr7:116140593 CAV2 -0.27 -5.86 -0.31 1.14e-8 Prevalent atrial fibrillation; LUSC trans rs1814175 0.586 rs10769603 chr11:49688837 T/C cg15704280 chr7:45808275 SEPT13 -0.99 -17.49 -0.69 4.27e-49 Height; LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg18110333 chr6:292329 DUSP22 0.5 7.64 0.39 2.28e-13 Menopause (age at onset); LUSC cis rs6840360 0.571 rs7685697 chr4:152558849 A/G cg22705602 chr4:152727874 NA -0.31 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs12579753 0.872 rs34415838 chr12:82122078 T/C cg21231944 chr12:82153410 PPFIA2 -0.4 -6.04 -0.31 4.13e-9 Resting heart rate; LUSC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08109568 chr15:31115862 NA -0.61 -8.12 -0.41 8.85e-15 Huntington's disease progression; LUSC cis rs7903847 0.642 rs7909345 chr10:99150794 T/C cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.66e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs11711311 1.000 rs2242109 chr3:113434100 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.15 0.36 5.64e-12 IgG glycosylation; LUSC cis rs7681440 0.801 rs1372513 chr4:90790237 G/A cg01966878 chr4:90757139 SNCA -0.33 -5.7 -0.3 2.67e-8 Dementia with Lewy bodies; LUSC cis rs6580649 0.598 rs1793913 chr12:48387025 T/A cg05342945 chr12:48394962 COL2A1 -0.44 -5.71 -0.3 2.54e-8 Lung cancer; LUSC trans rs2727943 0.688 rs4589912 chr3:1878635 G/A cg09243576 chr3:46850588 NA 0.51 6.12 0.32 2.58e-9 Bipolar disorder; LUSC cis rs73001065 0.818 rs12610191 chr19:19721976 C/T cg03709012 chr19:19516395 GATAD2A 0.89 7.15 0.36 5.34e-12 LDL cholesterol; LUSC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg13319975 chr6:146136371 FBXO30 0.51 7.87 0.4 4.96e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs10843647 0.967 rs1485406 chr12:30324053 T/G cg12718339 chr12:29936407 TMTC1 -0.36 -5.89 -0.31 9.41e-9 Glucose homeostasis traits; LUSC cis rs4285028 0.699 rs1920297 chr3:121598000 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.79 -10.77 -0.51 2.03e-23 Multiple sclerosis; LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -8.13 -0.41 8.56e-15 Lymphocyte counts; LUSC cis rs10208940 0.920 rs28361349 chr2:68785579 G/A cg12452813 chr2:68675892 NA 0.57 5.92 0.31 7.99e-9 Urate levels in lean individuals; LUSC cis rs11039100 1.000 rs35863965 chr11:5824256 G/T cg13902645 chr11:5959945 NA -0.53 -5.84 -0.3 1.21e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg06742321 chr12:123595122 PITPNM2 0.39 5.85 0.3 1.17e-8 Platelet count; LUSC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.68 -11.09 -0.52 1.48e-24 Prudent dietary pattern; LUSC cis rs2086824 0.702 rs3114891 chr16:89399455 A/G cg06640241 chr16:89574553 SPG7 0.52 7.74 0.39 1.22e-13 Multiple myeloma (IgH translocation); LUSC cis rs6693567 0.565 rs11205373 chr1:150404708 A/G cg15654264 chr1:150340011 RPRD2 0.43 6.8 0.35 4.74e-11 Migraine; LUSC cis rs911119 0.913 rs6036465 chr20:23588003 G/T cg16589663 chr20:23618590 CST3 0.56 6.83 0.35 3.91e-11 Chronic kidney disease; LUSC cis rs6582630 0.576 rs3900594 chr12:38272429 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.98 -0.36 1.63e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs642803 1.000 rs557675 chr11:65566719 G/T cg27068330 chr11:65405492 SIPA1 -0.53 -7.53 -0.38 4.92e-13 Urate levels; LUSC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg06238570 chr21:40685208 BRWD1 0.54 8.14 0.41 7.97e-15 Cognitive function; LUSC cis rs7246967 0.551 rs8102812 chr19:22879243 A/T cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg22906224 chr7:99728672 NA 0.63 8.67 0.43 1.85e-16 Coronary artery disease; LUSC cis rs921968 0.565 rs2272189 chr2:219610322 G/A cg02176678 chr2:219576539 TTLL4 -0.57 -10.08 -0.48 5.06e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs9329221 0.527 rs7833781 chr8:10333477 A/G cg27411982 chr8:10470053 RP1L1 0.44 6.63 0.34 1.34e-10 Neuroticism; LUSC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Tonsillectomy; LUSC trans rs10506458 0.834 rs17738403 chr12:63389200 A/G cg22491629 chr6:157744540 C6orf35 -0.91 -10.85 -0.51 1.06e-23 Hemostatic factors and hematological phenotypes; LUSC trans rs2262909 0.925 rs56073035 chr19:22276298 C/G cg05197062 chr11:11642011 GALNTL4 0.54 7.58 0.38 3.39e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs2067615 0.599 rs12369214 chr12:107198611 G/A cg15890332 chr12:107067104 RFX4 0.34 6.34 0.33 7.4e-10 Heart rate; LUSC trans rs11098499 0.779 rs7674500 chr4:120303593 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs7264396 0.836 rs4911183 chr20:34181553 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.55 8.01 0.4 1.89e-14 Total cholesterol levels; LUSC trans rs7746199 0.736 rs13202291 chr6:27698857 A/G cg06606381 chr12:133084897 FBRSL1 -0.94 -8.79 -0.43 8.32e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg12365402 chr11:9010492 NRIP3 -0.49 -9.32 -0.45 1.61e-18 Hemoglobin concentration; LUSC cis rs7267979 0.932 rs4280527 chr20:25544014 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.82 17.31 0.69 2.27e-48 Liver enzyme levels (alkaline phosphatase); LUSC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg06022373 chr22:39101656 GTPBP1 -0.8 -12.57 -0.57 6.06e-30 Menopause (age at onset); LUSC cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg18230493 chr5:56204884 C5orf35 -0.55 -8.43 -0.42 1.07e-15 Coronary artery disease; LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg01802117 chr1:53393560 SCP2 -0.37 -5.95 -0.31 6.66e-9 Monocyte count; LUSC cis rs9534288 0.702 rs7331472 chr13:46644173 C/T cg15192986 chr13:46630673 CPB2 -0.78 -11.82 -0.54 3.5e-27 Blood protein levels; LUSC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg11766577 chr21:47581405 C21orf56 -0.4 -5.74 -0.3 2.14e-8 Testicular germ cell tumor; LUSC cis rs2067615 0.579 rs10778509 chr12:107162918 G/A cg15890332 chr12:107067104 RFX4 0.35 6.28 0.33 1.03e-9 Heart rate; LUSC cis rs7208859 0.623 rs1061343 chr17:29114276 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs765787 0.530 rs2668737 chr15:45522799 C/T cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.5e-17 Uric acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26640895 chr4:71859472 DCK -0.41 -6.0 -0.31 5.17e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg15556689 chr8:8085844 FLJ10661 -0.5 -7.31 -0.37 2.03e-12 Myopia (pathological); LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg08088566 chr11:430123 ANO9 0.58 6.87 0.35 3.21e-11 Body mass index; LUSC trans rs8072100 0.840 rs12453233 chr17:45454570 C/T cg04995722 chr7:26192034 NFE2L3 -0.4 -6.56 -0.34 2.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs877282 0.898 rs11253352 chr10:766598 C/A cg22713356 chr15:30763199 NA 1.07 14.92 0.63 6.04e-39 Uric acid levels; LUSC cis rs7580658 0.550 rs62160290 chr2:128200695 C/T cg09760422 chr2:128146352 NA -0.27 -5.68 -0.3 2.87e-8 Protein C levels; LUSC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg23093090 chr10:104574429 C10orf26 0.45 8.52 0.42 5.63e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6500395 0.735 rs2883641 chr16:48664446 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.48 0.33 3.38e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg26408565 chr15:76604113 ETFA -0.49 -8.09 -0.4 1.14e-14 Blood metabolite levels; LUSC trans rs62238980 0.614 rs77407792 chr22:32461465 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs6121246 0.529 rs6060145 chr20:30178631 T/C cg13852791 chr20:30311386 BCL2L1 0.69 7.15 0.36 5.35e-12 Mean corpuscular hemoglobin; LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg09177884 chr7:1199841 ZFAND2A -0.45 -6.43 -0.33 4.54e-10 Longevity;Endometriosis; LUSC cis rs5769765 0.865 rs10854860 chr22:50320029 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.79 -10.41 -0.49 3.68e-22 Schizophrenia; LUSC cis rs1577917 0.771 rs4351223 chr6:86237797 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.51 0.42 5.77e-16 Response to antipsychotic treatment; LUSC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg20573242 chr4:122745356 CCNA2 0.54 7.94 0.4 3.1e-14 Type 2 diabetes; LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg16325326 chr1:53192061 ZYG11B -0.91 -16.89 -0.68 1.11e-46 Monocyte count; LUSC cis rs2970818 0.831 rs10849090 chr12:4669954 A/G cg11146114 chr12:4671731 NA -0.59 -5.96 -0.31 6.57e-9 Phosphorus levels; LUSC cis rs6987853 0.787 rs2974346 chr8:42401205 T/C cg09913449 chr8:42400586 C8orf40 0.54 9.31 0.45 1.7e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg16928487 chr17:17741425 SREBF1 -0.32 -5.96 -0.31 6.51e-9 Total body bone mineral density; LUSC cis rs11608355 0.960 rs11066526 chr12:109854476 G/C cg05360138 chr12:110035743 NA 0.46 6.34 0.33 7.41e-10 Neuroticism; LUSC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg20908204 chr19:46285434 DMPK 0.41 8.24 0.41 3.93e-15 Coronary artery disease; LUSC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg03433033 chr1:76189801 ACADM 0.75 10.49 0.5 1.9e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs55794721 0.509 rs6699896 chr1:25762902 A/T cg02931644 chr1:25747376 RHCE 0.37 6.8 0.35 4.82e-11 Plateletcrit;Mean corpuscular volume; LUSC cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg13010199 chr12:38710504 ALG10B 0.61 9.53 0.46 3.3e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg27129171 chr3:47204927 SETD2 0.67 11.29 0.53 2.85e-25 Colorectal cancer; LUSC cis rs2996428 0.629 rs12135894 chr1:3728061 C/T cg13057898 chr1:3703894 LRRC47 0.49 8.42 0.42 1.14e-15 Red cell distribution width; LUSC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12220238 1.000 rs7073432 chr10:75953350 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.8 0.35 4.73e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1595825 0.891 rs16825188 chr2:198741134 G/C cg00982548 chr2:198649783 BOLL -0.56 -7.03 -0.36 1.14e-11 Ulcerative colitis; LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg01125463 chr6:42946178 PEX6 -0.37 -6.07 -0.32 3.5e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3806933 0.522 rs11241095 chr5:110439509 A/G cg04022379 chr5:110408740 TSLP 0.66 9.58 0.46 2.3e-19 Eosinophilic esophagitis; LUSC cis rs11105298 0.891 rs11105319 chr12:89927177 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.51 -6.7 -0.34 8.75e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs62400317 0.787 rs10456547 chr6:45219526 T/C cg20913747 chr6:44695427 NA -0.48 -7.55 -0.38 4.08e-13 Total body bone mineral density; LUSC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg04850211 chr1:228464232 OBSCN -0.33 -6.07 -0.32 3.44e-9 Diastolic blood pressure; LUSC cis rs751728 0.664 rs2395402 chr6:33753673 G/A cg25922239 chr6:33757077 LEMD2 0.43 6.53 0.34 2.49e-10 Crohn's disease; LUSC cis rs5850 0.557 rs10270788 chr7:23189000 T/C cg23682824 chr7:23144976 KLHL7 0.4 5.71 0.3 2.52e-8 Blood protein levels; LUSC cis rs1971762 0.563 rs7975862 chr12:54078427 A/C cg23533419 chr12:54090519 NA 0.35 5.9 0.31 9.11e-9 Height; LUSC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg14416269 chr4:6271139 WFS1 0.54 11.47 0.53 6.87e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg22105103 chr4:187893119 NA -0.51 -8.0 -0.4 2.13e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg24296786 chr1:45957014 TESK2 0.53 8.37 0.42 1.57e-15 High light scatter reticulocyte count; LUSC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg26597838 chr10:835615 NA 0.95 13.57 0.6 1.01e-33 Eosinophil percentage of granulocytes; LUSC cis rs6076065 0.723 rs4815199 chr20:23347169 G/A cg11657817 chr20:23433608 CST11 0.43 8.14 0.41 7.67e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg27494647 chr7:150038898 RARRES2 -0.46 -7.04 -0.36 1.08e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs3008870 1.000 rs2985795 chr1:67426223 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.1 0.64 1.26e-39 Lymphocyte percentage of white cells; LUSC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg04166393 chr7:2884313 GNA12 0.43 5.65 0.3 3.42e-8 Height; LUSC cis rs7937682 0.883 rs1789351 chr11:111456436 T/A cg09085632 chr11:111637200 PPP2R1B -1.01 -15.59 -0.65 1.42e-41 Primary sclerosing cholangitis; LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg13395646 chr4:1353034 KIAA1530 -0.56 -8.51 -0.42 5.88e-16 Longevity; LUSC cis rs9815354 0.812 rs4264702 chr3:41952539 T/A cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs17818399 0.749 rs13000560 chr2:46790997 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.57 -7.41 -0.38 1.02e-12 Height; LUSC cis rs4730250 0.707 rs6946931 chr7:106788621 G/T cg02696742 chr7:106810147 HBP1 -0.63 -9.06 -0.44 1.15e-17 Osteoarthritis; LUSC trans rs1814175 0.817 rs3974439 chr11:50022607 G/A cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg04756594 chr16:24857601 SLC5A11 0.46 6.62 0.34 1.47e-10 Intelligence (multi-trait analysis); LUSC trans rs2262909 0.962 rs422344 chr19:22230956 C/G cg17074339 chr11:11642133 GALNTL4 0.45 6.93 0.35 2.15e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg03060546 chr3:49711283 APEH 0.7 11.51 0.53 4.69e-26 Resting heart rate; LUSC cis rs748404 0.660 rs2467742 chr15:43750237 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs9486715 1.000 rs6902835 chr6:97063005 C/G cg06623918 chr6:96969491 KIAA0776 -0.84 -14.46 -0.62 3.81e-37 Headache; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23359173 chr7:56119384 PSPH;CCT6A -0.41 -6.15 -0.32 2.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 11.11 0.52 1.3e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg14440974 chr22:39074834 NA -0.36 -5.96 -0.31 6.56e-9 Menopause (age at onset); LUSC cis rs16870629 0.564 rs326050 chr5:1002620 C/T cg00278107 chr5:1061253 SLC12A7 0.62 9.36 0.46 1.19e-18 QT interval; LUSC cis rs9814567 0.806 rs11927539 chr3:134319448 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.39 -0.56 2.93e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.81 -0.51 1.47e-23 Chronic sinus infection; LUSC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg07636037 chr3:49044803 WDR6 0.44 6.39 0.33 5.44e-10 Resting heart rate; LUSC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg03676636 chr4:99064102 C4orf37 0.37 7.65 0.39 2.14e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9733 0.687 rs12410050 chr1:150857141 A/G cg13175981 chr1:150552382 MCL1 0.46 6.52 0.34 2.67e-10 Tonsillectomy; LUSC cis rs7575217 0.961 rs11691031 chr2:101779358 A/G cg23907051 chr2:101730305 TBC1D8 0.27 6.76 0.35 6.29e-11 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs7937682 0.883 rs1611989 chr11:111456299 A/G cg22437258 chr11:111473054 SIK2 0.51 7.05 0.36 1e-11 Primary sclerosing cholangitis; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg11766577 chr21:47581405 C21orf56 -0.48 -7.12 -0.36 6.67e-12 Testicular germ cell tumor; LUSC cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg08085267 chr17:45401833 C17orf57 -0.54 -8.66 -0.43 2e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg01802117 chr1:53393560 SCP2 0.39 6.42 0.33 4.59e-10 Monocyte count; LUSC cis rs6582630 0.555 rs7301250 chr12:38596244 G/T cg26384229 chr12:38710491 ALG10B 0.86 14.35 0.62 1.04e-36 Drug-induced liver injury (flucloxacillin); LUSC cis rs12188164 0.502 rs55929184 chr5:405576 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.31 -6.8 -0.35 4.97e-11 Cystic fibrosis severity; LUSC trans rs11764590 0.715 rs55810445 chr7:2103739 C/T cg10840412 chr1:235813424 GNG4 0.51 6.12 0.32 2.63e-9 Neuroticism; LUSC cis rs877282 0.583 rs10904562 chr10:819058 T/C cg13775593 chr10:823151 NA 0.29 5.84 0.3 1.26e-8 Uric acid levels; LUSC cis rs9549367 0.789 rs2287250 chr13:113889474 C/T cg00898013 chr13:113819073 PROZ 0.52 7.91 0.4 3.69e-14 Platelet distribution width; LUSC cis rs601339 0.938 rs1696345 chr12:123183060 T/G cg11919336 chr12:123188078 GPR109A 0.44 6.58 0.34 1.87e-10 Adiponectin levels; LUSC cis rs977987 0.806 rs11864102 chr16:75442360 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.83 -0.35 4.03e-11 Dupuytren's disease; LUSC cis rs4474465 1.000 rs11237511 chr11:78173606 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.72 -0.3 2.42e-8 Alzheimer's disease (survival time); LUSC cis rs7666738 0.546 rs13149516 chr4:98913030 T/A cg17366294 chr4:99064904 C4orf37 0.52 8.55 0.42 4.5e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg27170947 chr2:26402098 FAM59B -0.63 -9.25 -0.45 2.68e-18 Gut microbiome composition (summer); LUSC cis rs4704187 0.687 rs6453112 chr5:74389901 A/C cg03227963 chr5:74354835 NA 0.32 6.82 0.35 4.21e-11 Response to amphetamines; LUSC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg12311346 chr5:56204834 C5orf35 -0.88 -12.73 -0.57 1.55e-30 Initial pursuit acceleration; LUSC trans rs7615952 0.673 rs34209763 chr3:125599595 G/A cg07211511 chr3:129823064 LOC729375 -0.99 -12.34 -0.56 4.37e-29 Blood pressure (smoking interaction); LUSC cis rs7824557 0.767 rs11250127 chr8:11170209 G/A cg21293242 chr8:11204541 TDH 0.32 5.91 0.31 8.66e-9 Retinal vascular caliber; LUSC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 7.3 0.37 2.09e-12 Cerebrospinal P-tau181p levels; LUSC cis rs9341808 0.538 rs620147 chr6:80992090 G/A cg08355045 chr6:80787529 NA -0.4 -6.87 -0.35 3.06e-11 Sitting height ratio; LUSC cis rs7607369 0.536 rs12990447 chr2:219667413 T/C cg02176678 chr2:219576539 TTLL4 -0.52 -9.15 -0.45 5.72e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.53 -6.38 -0.33 5.98e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs240764 0.548 rs12206838 chr6:101180128 G/A cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.54e-10 Neuroticism; LUSC cis rs8010715 0.636 rs2277480 chr14:24587515 G/A cg23112188 chr14:24563095 PCK2 -0.32 -5.96 -0.31 6.29e-9 IgG glycosylation; LUSC cis rs34779708 0.931 rs12768019 chr10:35389843 T/C cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.73 0.51 2.93e-23 Monocyte percentage of white cells; LUSC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg00166722 chr3:10149974 C3orf24 0.42 6.21 0.32 1.56e-9 Alzheimer's disease; LUSC cis rs9467773 0.935 rs1884947 chr6:26553273 G/T cg05738196 chr6:26577821 NA 0.79 14.12 0.61 7.83e-36 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs400736 0.859 rs379920 chr1:8028865 G/C cg25007680 chr1:8021821 PARK7 0.6 9.45 0.46 6.26e-19 Response to antidepressants and depression; LUSC cis rs13720 0.673 rs163802 chr20:57578852 C/G cg23907860 chr20:57583709 CTSZ -0.48 -6.34 -0.33 7.34e-10 Platelet distribution width; LUSC cis rs950776 0.642 rs922691 chr15:78963994 A/G cg06917634 chr15:78832804 PSMA4 0.5 7.02 0.36 1.22e-11 Sudden cardiac arrest; LUSC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg07212818 chr11:638076 DRD4 -0.45 -7.51 -0.38 5.29e-13 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04094723 chr17:73717212 ITGB4 -0.4 -6.07 -0.32 3.54e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs950169 0.922 rs17531523 chr15:85132449 C/G cg17173187 chr15:85201210 NMB 0.38 6.62 0.34 1.45e-10 Schizophrenia; LUSC cis rs3768617 0.510 rs2027076 chr1:183073407 C/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.91 0.51 6.39e-24 Fuchs's corneal dystrophy; LUSC cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.54e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg04352962 chr1:209979756 IRF6 -0.52 -6.19 -0.32 1.77e-9 Cleft lip with or without cleft palate; LUSC cis rs12618769 0.597 rs3754892 chr2:99063318 T/A cg10123293 chr2:99228465 UNC50 0.46 7.04 0.36 1.08e-11 Bipolar disorder; LUSC cis rs12472274 0.941 rs11677230 chr2:239092054 T/C cg17459225 chr2:239074497 NA 0.63 10.09 0.48 4.6e-21 Phospholipid levels (plasma); LUSC cis rs6089584 1.000 rs3787424 chr20:60559219 G/A cg13770153 chr20:60521292 NA -0.6 -8.35 -0.42 1.79e-15 Body mass index; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.09 0.45 9.17e-18 Prudent dietary pattern; LUSC cis rs9420 0.961 rs11604333 chr11:57467035 C/G cg23127183 chr11:57508653 C11orf31 -0.58 -9.06 -0.44 1.08e-17 Schizophrenia; LUSC cis rs4253772 0.872 rs78864133 chr22:46638486 C/T cg09491104 chr22:46646882 C22orf40 -0.59 -6.52 -0.34 2.6200000000000003e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs354225 0.544 rs1137645 chr2:54807592 C/G cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs2952156 1.000 rs1810132 chr17:37866005 C/T cg00129232 chr17:37814104 STARD3 -0.4 -5.82 -0.3 1.39e-8 Asthma; LUSC cis rs8114671 0.967 rs4911478 chr20:33782625 A/C cg24642439 chr20:33292090 TP53INP2 -0.4 -5.92 -0.31 7.84e-9 Height; LUSC cis rs7666738 0.753 rs17027308 chr4:99091088 T/A cg03676636 chr4:99064102 C4orf37 0.29 6.23 0.32 1.38e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs983392 0.617 rs667897 chr11:59936979 C/T cg24026212 chr11:59952134 MS4A6A 0.34 6.43 0.33 4.29e-10 Alzheimer's disease (late onset); LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg14830002 chr1:247616686 OR2B11 0.5 7.81 0.39 7.23e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs16910800 0.953 rs7122949 chr11:23203530 C/T cg20040320 chr11:23191996 NA 0.43 6.28 0.32 1.06e-9 Cancer; LUSC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.87 0.31 1.03e-8 Menopause (age at onset); LUSC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg02187348 chr16:89574699 SPG7 -0.49 -6.72 -0.34 8.02e-11 Multiple myeloma (IgH translocation); LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs3770081 1.000 rs3770090 chr2:86263288 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.8 -5.68 -0.3 2.96e-8 Facial emotion recognition (sad faces); LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.82e-10 Bipolar disorder; LUSC cis rs360798 0.512 rs2710640 chr2:63144305 A/G cg17519650 chr2:63277830 OTX1 0.52 7.24 0.37 3.06e-12 Coronary artery disease; LUSC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg16447950 chr5:562315 NA -0.53 -6.97 -0.36 1.69e-11 Obesity-related traits; LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg03188948 chr7:1209495 NA 0.67 7.1 0.36 7.38e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21528273 chr1:44056889 PTPRF 0.4 6.11 0.32 2.7e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs1143633 0.530 rs2723163 chr2:113694339 A/G cg06156847 chr2:113672199 IL1F7 -0.28 -5.96 -0.31 6.58e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2074585 0.560 rs12903058 chr15:91061121 G/T cg10434728 chr15:90938212 IQGAP1 -0.35 -6.53 -0.34 2.4e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs7131987 0.903 rs2194518 chr12:29419460 C/T cg09582351 chr12:29534625 ERGIC2 -0.31 -6.52 -0.34 2.67e-10 QT interval; LUSC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg19774624 chr17:42201019 HDAC5 -0.81 -13.25 -0.59 1.7e-32 Total body bone mineral density; LUSC cis rs3806843 1.000 rs10053586 chr5:140210760 T/C cg03975922 chr5:140080575 ZMAT2 0.33 5.97 0.31 6.2e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg12639453 chr1:2035780 PRKCZ -0.3 -6.42 -0.33 4.66e-10 Height; LUSC cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.84 0.39 6.15e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs338389 0.586 rs338400 chr15:68254156 C/T cg16317052 chr17:61678891 TACO1 0.38 5.95 0.31 6.89e-9 Survival in rectal cancer; LUSC cis rs7463659 0.935 rs7844624 chr8:135433894 T/C cg17885191 chr8:135476712 NA -0.4 -5.66 -0.3 3.19e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.930 rs4668909 chr2:15607842 T/C cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.36e-16 Educational attainment (years of education); LUSC cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg06060754 chr5:176797920 RGS14 0.56 8.94 0.44 2.78e-17 Hemoglobin concentration;Hematocrit; LUSC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.72 -0.3 2.34e-8 Extrinsic epigenetic age acceleration; LUSC cis rs11155671 0.530 rs6933882 chr6:150210802 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC cis rs2204008 0.528 rs11503820 chr12:38395379 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.28 -0.41 3.1e-15 Bladder cancer; LUSC cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg10172584 chr19:19639581 YJEFN3 -0.52 -6.15 -0.32 2.26e-9 Bipolar disorder; LUSC cis rs12477438 0.765 rs7605218 chr2:99593080 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.75 -0.51 2.45e-23 Chronic sinus infection; LUSC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.5 6.16 0.32 2.15e-9 Multiple sclerosis; LUSC trans rs11098499 0.908 rs28559989 chr4:120386627 C/T cg25214090 chr10:38739885 LOC399744 0.57 8.37 0.42 1.56e-15 Corneal astigmatism; LUSC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC trans rs61931739 0.500 rs10844863 chr12:34532284 C/T cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs804280 0.662 rs11784764 chr8:11610874 C/T cg26752888 chr8:11627280 NEIL2 0.54 6.93 0.35 2.23e-11 Myopia (pathological); LUSC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg13206674 chr6:150067644 NUP43 0.57 8.99 0.44 1.91e-17 Lung cancer; LUSC cis rs432925 0.529 rs9925945 chr16:393564 A/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.39 5.98 0.31 5.73e-9 Morning vs. evening chronotype; LUSC trans rs1325195 0.881 rs400976 chr1:179217582 T/C cg11624085 chr17:8464688 MYH10 0.44 7.1 0.36 7.36e-12 IgE grass sensitization; LUSC cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg22782873 chr19:19639568 YJEFN3 -0.47 -5.69 -0.3 2.8e-8 Bipolar disorder; LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg05368731 chr17:41323189 NBR1 0.94 16.31 0.67 2.19e-44 Menopause (age at onset); LUSC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg09491104 chr22:46646882 C22orf40 -0.7 -7.3 -0.37 2.14e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs6541297 1.000 rs6541297 chr1:230283506 G/A cg05784532 chr1:230284198 GALNT2 0.52 7.79 0.39 8.67e-14 Coronary artery disease; LUSC cis rs9362426 0.943 rs7744338 chr6:88101999 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.41 6.27 0.32 1.12e-9 Depressive episodes in bipolar disorder; LUSC cis rs7408868 1.000 rs10410514 chr19:15277610 C/T cg14696996 chr19:15285081 NOTCH3 0.96 9.25 0.45 2.69e-18 Pulse pressure; LUSC cis rs10782582 0.593 rs77733234 chr1:76101655 A/T cg22875332 chr1:76189707 ACADM -0.43 -6.46 -0.33 3.8e-10 Daytime sleep phenotypes; LUSC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg03804128 chr16:635623 NA 0.3 5.85 0.3 1.17e-8 Height; LUSC cis rs13064411 0.696 rs1552432 chr3:113225660 G/C cg18753928 chr3:113234510 CCDC52 -0.5 -7.74 -0.39 1.2e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg17366294 chr4:99064904 C4orf37 0.54 9.48 0.46 4.75e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg07256732 chr16:621771 PIGQ -0.35 -6.31 -0.33 8.62e-10 Height; LUSC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg04362960 chr10:104952993 NT5C2 0.52 6.54 0.34 2.35e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs317689 0.819 rs317677 chr12:69691806 G/A cg20891283 chr12:69753455 YEATS4 0.45 6.17 0.32 1.98e-9 Response to diuretic therapy; LUSC trans rs1908814 0.516 rs56102998 chr8:11796675 G/A cg15556689 chr8:8085844 FLJ10661 0.58 8.63 0.43 2.48e-16 Neuroticism; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10292851 chr8:101572103 ANKRD46 -0.43 -6.25 -0.32 1.23e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7084921 0.578 rs12776318 chr10:101868677 T/G cg02250046 chr10:101825185 CPN1 -0.34 -6.16 -0.32 2.05e-9 Bone mineral density; LUSC cis rs11997175 0.545 rs7388496 chr8:33667898 A/G ch.8.33884649F chr8:33765107 NA 0.44 6.31 0.33 8.83e-10 Body mass index; LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg07362569 chr17:61921086 SMARCD2 0.37 7.33 0.37 1.69e-12 Prudent dietary pattern; LUSC cis rs3007168 1.000 rs2999362 chr14:51605265 A/G cg23942311 chr14:51606299 NA 0.37 6.02 0.31 4.5e-9 Cancer; LUSC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg22535103 chr8:58192502 C8orf71 -0.74 -7.39 -0.37 1.22e-12 Developmental language disorder (linguistic errors); LUSC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg03709012 chr19:19516395 GATAD2A -0.76 -11.92 -0.55 1.62e-27 Tonsillectomy; LUSC cis rs10089 1.000 rs10478796 chr5:127436187 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.17 0.55 1.88e-28 Ileal carcinoids; LUSC cis rs11971779 0.555 rs6950143 chr7:139054418 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg16362232 chr11:430036 ANO9 0.58 7.69 0.39 1.71e-13 Body mass index; LUSC cis rs354225 0.586 rs966003 chr2:54884870 C/T cg26097391 chr2:54893211 SPTBN1 0.43 7.22 0.37 3.56e-12 Schizophrenia; LUSC cis rs9905704 0.846 rs302861 chr17:56697040 G/C cg12560992 chr17:57184187 TRIM37 0.58 8.38 0.42 1.49e-15 Testicular germ cell tumor; LUSC cis rs524023 0.957 rs893007 chr11:64365668 C/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.24 -0.49 1.44e-21 Urate levels in obese individuals; LUSC trans rs9380880 0.826 rs12175102 chr6:39554898 C/T cg09045552 chr2:169506620 LASS6 -0.67 -6.26 -0.32 1.18e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs9311676 0.656 rs12495490 chr3:58373251 A/G cg13750441 chr3:58318267 PXK 0.35 6.7 0.34 9.04e-11 Systemic lupus erythematosus; LUSC cis rs8014204 0.836 rs7153700 chr14:75268544 C/T cg06637938 chr14:75390232 RPS6KL1 0.63 10.57 0.5 9.79e-23 Caffeine consumption; LUSC cis rs40363 1.000 rs37768 chr16:3514777 T/C cg05754148 chr16:3507555 NAT15 0.81 9.78 0.47 5.12e-20 Tuberculosis; LUSC cis rs2742234 0.590 rs2505557 chr10:43666016 C/T cg15436174 chr10:43711423 RASGEF1A -0.44 -7.06 -0.36 9.87e-12 Hirschsprung disease; LUSC cis rs11190604 1.000 rs1417823 chr10:102227886 C/T cg07080220 chr10:102295463 HIF1AN -0.61 -8.51 -0.42 6.12e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1577917 1.000 rs12208493 chr6:86662267 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.73 -0.43 1.23e-16 Response to antipsychotic treatment; LUSC trans rs2204008 0.683 rs12370288 chr12:38127740 G/A cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.08e-9 Bladder cancer; LUSC cis rs7202877 0.706 rs247425 chr16:75460402 C/T cg03315344 chr16:75512273 CHST6 -0.42 -6.03 -0.31 4.42e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs1395 1.000 rs4665958 chr2:27443196 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.4 6.52 0.34 2.53e-10 Blood metabolite levels; LUSC cis rs8141529 0.732 rs6005872 chr22:29172898 T/G cg15103426 chr22:29168792 CCDC117 0.58 8.02 0.4 1.86e-14 Lymphocyte counts; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg16145915 chr7:1198662 ZFAND2A -0.77 -17.76 -0.7 3.62e-50 Longevity;Endometriosis; LUSC cis rs6750047 0.546 rs2082255 chr2:38273758 C/A cg07380506 chr2:38303506 CYP1B1 0.45 6.18 0.32 1.88e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7712401 0.601 rs2126935 chr5:122313571 A/G cg19077854 chr5:122220652 SNX24 -0.39 -8.52 -0.42 5.65e-16 Mean platelet volume; LUSC cis rs9309473 0.519 rs4852950 chr2:73864670 C/T cg20560298 chr2:73613845 ALMS1 0.43 6.6 0.34 1.64e-10 Metabolite levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20088535 chr4:128802013 PLK4 0.48 6.59 0.34 1.68e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg08807101 chr21:30365312 RNF160 -0.72 -12.81 -0.57 7.8e-31 Dental caries; LUSC cis rs317689 0.581 rs315132 chr12:69761996 G/C cg20891283 chr12:69753455 YEATS4 0.65 9.74 0.47 7.01e-20 Response to diuretic therapy; LUSC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg03354898 chr7:1950403 MAD1L1 -0.31 -5.93 -0.31 7.65e-9 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs1348850 0.914 rs12469386 chr2:178358281 A/G cg22681709 chr2:178499509 PDE11A 0.51 9.54 0.46 3.12e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -8.27 -0.41 3.31e-15 Axial length; LUSC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.23 -0.32 1.41e-9 Joint mobility (Beighton score); LUSC trans rs7829975 0.774 rs35431455 chr8:8673736 T/C cg27411982 chr8:10470053 RP1L1 0.41 6.38 0.33 5.93e-10 Mood instability; LUSC cis rs7523050 0.558 rs35926243 chr1:109407712 T/A cg08274380 chr1:109419600 GPSM2 1.12 10.7 0.51 3.48e-23 Fat distribution (HIV); LUSC cis rs8072100 0.782 rs62074054 chr17:45771816 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.38 -6.33 -0.33 7.89e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4253772 0.550 rs9615347 chr22:46728153 A/G cg24881330 chr22:46731750 TRMU 0.8 6.64 0.34 1.25e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg16339924 chr4:17578868 LAP3 0.57 8.63 0.43 2.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4917833 0.789 rs10883099 chr10:100219314 G/A cg19043522 chr10:100227446 HPSE2 0.4 5.71 0.3 2.53e-8 Pediatric bone mineral density (femoral neck); LUSC cis rs8060686 0.641 rs7188085 chr16:68113873 A/G cg26727032 chr16:67993705 SLC12A4 -0.42 -5.75 -0.3 2.01e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg07636037 chr3:49044803 WDR6 1.07 18.05 0.7 2.65e-51 Parkinson's disease; LUSC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg12463550 chr7:65579703 CRCP -0.63 -5.68 -0.3 2.92e-8 Diabetic kidney disease; LUSC cis rs7937682 1.000 rs11608122 chr11:111535105 C/T cg09085632 chr11:111637200 PPP2R1B 1.07 16.23 0.66 4.41e-44 Primary sclerosing cholangitis; LUSC cis rs9392556 0.765 rs613709 chr6:4120683 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.21 -0.32 1.55e-9 Blood metabolite levels; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg06145435 chr7:1022769 CYP2W1 0.32 6.58 0.34 1.82e-10 Longevity;Endometriosis; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg23131131 chr22:24373011 LOC391322 0.51 7.45 0.38 7.88e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7819412 0.775 rs4841490 chr8:10936891 T/C cg15556689 chr8:8085844 FLJ10661 -0.5 -7.39 -0.37 1.19e-12 Triglycerides; LUSC cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg05985134 chr18:33552581 C18orf21 0.5 6.87 0.35 3.19e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs992157 0.764 rs4672886 chr2:219185545 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.44 -6.63 -0.34 1.35e-10 Colorectal cancer; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg24357026 chr19:36705589 ZNF565;ZNF146 -0.51 -6.05 -0.31 3.93e-9 Height; LUSC cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.45 0.33 3.89e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs35883536 0.647 rs945329 chr1:101084273 C/T cg06223162 chr1:101003688 GPR88 -0.44 -7.71 -0.39 1.46e-13 Monocyte count; LUSC cis rs6598955 0.502 rs6683157 chr1:26545865 G/A cg12744634 chr1:26560303 CCDC21 0.39 5.8 0.3 1.53e-8 Obesity-related traits; LUSC cis rs2197308 0.692 rs7488528 chr12:37912971 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.61 0.5 7.47e-23 Morning vs. evening chronotype; LUSC cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg04455712 chr21:45112962 RRP1B 0.44 8.37 0.42 1.61e-15 Mean corpuscular volume; LUSC cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg08999081 chr20:33150536 PIGU 0.38 6.8 0.35 4.87e-11 Height; LUSC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg01802117 chr1:53393560 SCP2 -0.37 -6.18 -0.32 1.83e-9 Monocyte count; LUSC cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.69 0.43 1.62e-16 Motion sickness; LUSC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg14196790 chr5:131705035 SLC22A5 -0.43 -6.97 -0.36 1.69e-11 Breast cancer;Mosquito bite size; LUSC trans rs11782517 0.924 rs35222693 chr8:10108790 A/G cg15556689 chr8:8085844 FLJ10661 0.48 6.25 0.32 1.26e-9 Nose size; LUSC cis rs62400317 0.859 rs62400326 chr6:45287465 T/C cg18551225 chr6:44695536 NA -0.42 -7.1 -0.36 7.71e-12 Total body bone mineral density; LUSC trans rs9650657 0.530 rs6982381 chr8:10952500 A/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.89 -0.35 2.73e-11 Neuroticism; LUSC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg25894440 chr7:65020034 NA -0.38 -6.02 -0.31 4.69e-9 Calcium levels; LUSC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg05347473 chr6:146136440 FBXO30 -0.58 -10.06 -0.48 5.68e-21 Lobe attachment (rater-scored or self-reported); LUSC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg22433210 chr17:43662623 NA 0.69 9.91 0.48 1.87e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC cis rs2050392 0.517 rs2480299 chr10:30743197 G/A cg25182066 chr10:30743637 MAP3K8 -0.47 -6.71 -0.34 8.56e-11 Inflammatory bowel disease; LUSC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg04369109 chr6:150039330 LATS1 -0.56 -8.35 -0.42 1.84e-15 Lung cancer; LUSC cis rs2841277 0.646 rs2819419 chr14:105406238 A/C cg19901468 chr14:105411992 AHNAK2 -0.71 -12.12 -0.55 2.76e-28 Rheumatoid arthritis; LUSC cis rs11098499 0.954 rs2389803 chr4:120393511 A/G cg09307838 chr4:120376055 NA -0.79 -11.61 -0.54 2.07e-26 Corneal astigmatism; LUSC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 9.09 0.45 8.97e-18 Tonsillectomy; LUSC cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.57e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs11098499 0.865 rs28634456 chr4:120375778 A/G cg25214090 chr10:38739885 LOC399744 0.57 8.27 0.41 3.3e-15 Corneal astigmatism; LUSC cis rs701145 0.556 rs355762 chr3:154012614 G/A cg10247383 chr3:153839028 SGEF -0.47 -5.78 -0.3 1.72e-8 Coronary artery disease; LUSC cis rs79387448 0.701 rs10515921 chr2:102981018 T/G cg09003973 chr2:102972529 NA 1.21 12.76 0.57 1.2e-30 Gut microbiota (bacterial taxa); LUSC trans rs62238980 0.614 rs77099614 chr22:32452759 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg06640241 chr16:89574553 SPG7 -0.67 -10.76 -0.51 2.2e-23 Multiple myeloma (IgH translocation); LUSC cis rs5758659 1.000 rs134900 chr22:42683343 C/G cg04733989 chr22:42467013 NAGA 0.39 6.2 0.32 1.67e-9 Cognitive function; LUSC cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg24642439 chr20:33292090 TP53INP2 0.74 12.09 0.55 3.55e-28 Coronary artery disease; LUSC trans rs12692738 0.526 rs355867 chr2:165631057 C/T cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg27286337 chr10:134555280 INPP5A 0.91 11.26 0.52 3.64e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4280164 0.836 rs4981504 chr14:24791136 A/G cg16194253 chr14:24768981 DHRS1;C14orf21 0.59 6.99 0.36 1.53e-11 Parent of origin effect on language impairment (paternal); LUSC cis rs1801251 0.963 rs7562712 chr2:233606580 A/G cg08000102 chr2:233561755 GIGYF2 0.68 11.26 0.52 3.82e-25 Coronary artery disease; LUSC cis rs9303542 0.559 rs2326012 chr17:46618581 C/T cg09704116 chr17:46666958 LOC404266 -0.39 -7.14 -0.36 5.92e-12 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs950169 0.580 rs4603535 chr15:85173872 C/T cg12863693 chr15:85201151 NMB 0.39 8.2 0.41 5.1e-15 Schizophrenia; LUSC cis rs12956009 0.518 rs983095 chr18:44899258 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.42 0.33 4.56e-10 Educational attainment (years of education); LUSC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg01579765 chr21:45077557 HSF2BP -0.5 -10.38 -0.49 4.45e-22 Mean corpuscular volume; LUSC trans rs208520 0.874 rs208517 chr6:66947040 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.93 -0.61 4.39e-35 Exhaled nitric oxide output; LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs748404 0.697 rs567357 chr15:43571390 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.43 5.99 0.31 5.34e-9 Lung cancer; LUSC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.76 0.68 3.58e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs9329221 0.537 rs2062331 chr8:9979992 C/T cg21775007 chr8:11205619 TDH -0.44 -6.32 -0.33 8.46e-10 Neuroticism; LUSC cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg07148914 chr20:33460835 GGT7 0.53 8.12 0.41 8.96e-15 Height; LUSC cis rs6714710 0.603 rs11684749 chr2:98420142 G/C cg26665480 chr2:98280029 ACTR1B 0.58 8.52 0.42 5.7e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs637571 0.546 rs10791827 chr11:65596546 C/A cg17712092 chr4:129076599 LARP1B -0.8 -11.77 -0.54 5.56e-27 Eosinophil percentage of white cells; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03284175 chr1:146643471 PRKAB2 0.35 6.18 0.32 1.89e-9 Triglycerides; LUSC cis rs17818399 1.000 rs17818399 chr2:46826026 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.47 -6.32 -0.33 8.56e-10 Height; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg16325326 chr1:53192061 ZYG11B 0.81 14.3 0.62 1.62e-36 Monocyte count; LUSC trans rs750134 1.000 rs12582815 chr12:109117378 C/A cg23338993 chr2:234600423 UGT1A10;UGT1A6;UGT1A9;UGT1A7;UGT1A8 0.48 6.05 0.31 3.94e-9 Low high density lipoprotein cholesterol levels; LUSC cis rs7474896 0.522 rs117157955 chr10:37984164 G/T cg25427524 chr10:38739819 LOC399744 -0.48 -6.39 -0.33 5.62e-10 Obesity (extreme); LUSC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg00745463 chr17:30367425 LRRC37B -0.74 -9.02 -0.44 1.49e-17 Hip circumference adjusted for BMI; LUSC trans rs11098499 0.708 rs10005237 chr4:120237897 T/C cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg08999081 chr20:33150536 PIGU -0.53 -10.47 -0.5 2.26e-22 Glomerular filtration rate (creatinine); LUSC trans rs6502050 0.799 rs7406257 chr17:80089340 G/A cg07393940 chr7:158741817 NA 0.38 6.88 0.35 2.92e-11 Life satisfaction; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg09033563 chr22:24373618 LOC391322 0.53 8.38 0.42 1.46e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg00810483 chr4:3375144 RGS12 0.31 5.75 0.3 2.05e-8 Serum sulfate level; LUSC cis rs10207060 0.500 rs7600350 chr2:240716225 T/C cg07506560 chr2:240697449 NA 0.45 6.98 0.36 1.58e-11 Obesity-related traits; LUSC cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 5.93 0.31 7.74e-9 Personality dimensions; LUSC cis rs2463822 0.925 rs72923272 chr11:62166832 G/A cg06239285 chr11:62104954 ASRGL1 -0.97 -10.05 -0.48 6.38e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg03579872 chr1:53393473 SCP2 -0.39 -5.7 -0.3 2.6e-8 Monocyte count; LUSC cis rs887829 0.570 rs6759892 chr2:234601669 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.39 6.31 0.33 8.84e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.39 0.56 2.78e-29 Colorectal cancer; LUSC cis rs17604090 0.941 rs114036198 chr7:29676300 C/T cg19413766 chr7:29689036 LOC646762 -0.6 -6.77 -0.35 5.81e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs4077515 0.874 rs35670379 chr9:139270606 T/C cg14169450 chr9:139327907 INPP5E 0.42 7.62 0.39 2.56e-13 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6977660 1.000 rs10279525 chr7:19822305 C/T cg05791153 chr7:19748676 TWISTNB 0.54 6.03 0.31 4.33e-9 Thyroid stimulating hormone; LUSC cis rs733592 0.524 rs10875727 chr12:48426143 T/C cg24011408 chr12:48396354 COL2A1 -0.54 -8.92 -0.44 3.13e-17 Plateletcrit; LUSC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg05373962 chr22:49881684 NA 0.42 10.2 0.49 1.94e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg20887711 chr4:1340912 KIAA1530 -0.7 -10.93 -0.51 5.53e-24 Longevity; LUSC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg20307385 chr11:47447363 PSMC3 0.44 5.8 0.3 1.58e-8 Subjective well-being; LUSC cis rs478304 0.718 rs61744384 chr11:65387378 T/A cg05805236 chr11:65401703 PCNXL3 -0.5 -8.15 -0.41 7.34e-15 Acne (severe); LUSC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.39 -0.33 5.51e-10 Mood instability; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg07677032 chr17:61819896 STRADA 0.52 8.64 0.43 2.42e-16 Prudent dietary pattern; LUSC cis rs10489202 0.908 rs6692861 chr1:168079553 G/C cg24449463 chr1:168025552 DCAF6 -0.55 -6.8 -0.35 4.97e-11 Schizophrenia; LUSC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.78 -0.35 5.61e-11 Intelligence (multi-trait analysis); LUSC cis rs9788682 0.747 rs2915695 chr15:78739471 T/C cg24631222 chr15:78858424 CHRNA5 -0.67 -8.86 -0.44 4.69e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs136211 0.577 rs9610498 chr22:36777739 C/T cg16924664 chr22:36878180 TXN2 0.38 5.76 0.3 1.87e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg22638593 chr5:131593259 PDLIM4 0.49 7.46 0.38 7.65e-13 Acylcarnitine levels; LUSC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg13180566 chr4:1052158 NA -0.34 -5.66 -0.3 3.2e-8 Recombination rate (females); LUSC cis rs7258465 1.000 rs4808136 chr19:18618867 A/G cg15073853 chr19:18549131 ISYNA1 0.3 5.72 0.3 2.33e-8 Breast cancer; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg06877462 chr1:205807181 PM20D1 0.54 10.18 0.49 2.2e-21 Menarche (age at onset); LUSC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg25072359 chr17:41440525 NA 0.65 9.29 0.45 2e-18 Menopause (age at onset); LUSC cis rs926938 0.618 rs360675 chr1:115490918 T/C cg12756093 chr1:115239321 AMPD1 0.49 7.58 0.38 3.53e-13 Autism; LUSC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 9.07 0.44 1.06e-17 Menopause (age at onset); LUSC cis rs748404 0.697 rs530683 chr15:43568999 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.43 -6.06 -0.31 3.63e-9 Lung cancer; LUSC cis rs55728055 0.661 rs7293143 chr22:32013365 A/G cg01338084 chr22:32026380 PISD -0.84 -6.23 -0.32 1.39e-9 Age-related hearing impairment; LUSC cis rs9640161 0.783 rs35435439 chr7:150063534 C/T cg17279839 chr7:150038598 RARRES2 0.4 6.11 0.32 2.75e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs2587949 0.615 rs1485247 chr3:4238196 C/T cg15139668 chr4:4577005 NA -0.41 -6.26 -0.32 1.19e-9 Periodontitis (DPAL); LUSC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.59 -0.38 3.21e-13 Personality dimensions; LUSC cis rs3126085 0.877 rs3120672 chr1:152255575 A/G cg26876637 chr1:152193138 HRNR 0.45 6.08 0.32 3.31e-9 Atopic dermatitis; LUSC cis rs2046867 0.862 rs11922180 chr3:72836119 A/G cg25664220 chr3:72788482 NA 0.65 10.8 0.51 1.57e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07113562 chr10:52834093 PRKG1 0.46 6.97 0.36 1.74e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg07835181 chr16:1525278 CLCN7 0.73 12.44 0.56 1.84e-29 Bone mineral density; LUSC cis rs3740713 1.000 rs12289603 chr11:18471370 T/C cg23797887 chr11:18477753 LDHAL6A -0.54 -6.59 -0.34 1.69e-10 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs11039798 0.614 rs2174703 chr11:48788242 G/A cg15704280 chr7:45808275 SEPT13 0.77 7.41 0.38 1.01e-12 Axial length; LUSC cis rs17828380 0.920 rs17762822 chr15:63601379 G/A cg05507819 chr15:63340323 TPM1 -0.75 -6.12 -0.32 2.59e-9 Social communication problems; LUSC cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg23158103 chr7:148848205 ZNF398 -0.5 -8.33 -0.41 2.05e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs656319 0.580 rs13272793 chr8:10002027 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -6.88 -0.35 3.02e-11 Myopia (pathological); LUSC trans rs11098499 0.954 rs11729521 chr4:120416788 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs11690935 0.610 rs3770458 chr2:172651287 C/T cg13550731 chr2:172543902 DYNC1I2 0.57 8.75 0.43 1.04e-16 Schizophrenia; LUSC cis rs909341 0.909 rs1291210 chr20:62335293 A/C cg09650180 chr20:62225654 GMEB2 -0.45 -5.9 -0.31 8.8e-9 Atopic dermatitis; LUSC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg08859206 chr1:53392774 SCP2 -0.43 -7.04 -0.36 1.09e-11 Monocyte count; LUSC cis rs2070488 0.699 rs6599205 chr3:38529440 C/G cg24069376 chr3:38537580 EXOG 0.42 8.2 0.41 5.24e-15 Electrocardiographic conduction measures; LUSC trans rs8073060 0.660 rs34184070 chr17:34003810 A/G cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs11098499 0.818 rs12498599 chr4:120468503 C/T cg25214090 chr10:38739885 LOC399744 0.54 7.98 0.4 2.39e-14 Corneal astigmatism; LUSC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg18876405 chr7:65276391 NA 0.67 11.76 0.54 6.2e-27 Aortic root size; LUSC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC trans rs12210905 1.000 rs9357034 chr6:27243425 C/G cg11837749 chr1:55047332 ACOT11 0.6 6.17 0.32 2.01e-9 Hip circumference adjusted for BMI; LUSC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6545883 0.859 rs2600661 chr2:61543081 T/C cg15711740 chr2:61764176 XPO1 0.47 7.57 0.38 3.78e-13 Tuberculosis; LUSC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg16506815 chr2:162101123 NA 0.42 6.28 0.32 1.07e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs1178968 0.901 rs757937 chr7:72750159 C/T cg25889504 chr7:72793014 NA 0.59 7.96 0.4 2.69e-14 Triglyceride levels; LUSC cis rs7923609 0.812 rs10822155 chr10:65071215 C/A cg01631684 chr10:65280961 REEP3 -0.38 -5.65 -0.3 3.49e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg09034736 chr1:150693464 HORMAD1 -0.39 -5.67 -0.3 3.12e-8 Tonsillectomy; LUSC cis rs344364 0.636 rs344363 chr16:1972548 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.67 -7.88 -0.4 4.68e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7267979 0.833 rs4619688 chr20:25244101 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.33 0.67 1.73e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg17252645 chr8:143867129 LY6D 0.38 6.68 0.34 1.01e-10 Urinary tract infection frequency; LUSC cis rs6541297 1.000 rs1998065 chr1:230286647 T/G cg05784532 chr1:230284198 GALNT2 0.55 8.19 0.41 5.67e-15 Coronary artery disease; LUSC cis rs7824557 0.628 rs58283816 chr8:11192551 G/C cg21775007 chr8:11205619 TDH 0.79 13.35 0.59 7.08e-33 Retinal vascular caliber; LUSC trans rs12210905 0.541 rs62617138 chr6:27463766 C/A cg14616345 chr9:133901267 LAMC3 -0.7 -5.99 -0.31 5.54e-9 Hip circumference adjusted for BMI; LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg13047869 chr3:10149882 C3orf24 0.6 8.12 0.41 9.19e-15 Alzheimer's disease; LUSC trans rs7567288 0.636 rs12998809 chr2:134466883 T/C cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4853012 1.000 rs2280643 chr2:74358286 T/C cg05890377 chr2:74357713 NA 0.75 14.26 0.62 2.24e-36 Gestational age at birth (maternal effect); LUSC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg25174290 chr11:3078921 CARS 0.6 9.17 0.45 4.85e-18 Longevity; LUSC cis rs6714710 0.603 rs2305143 chr2:98413781 C/T cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg09177884 chr7:1199841 ZFAND2A -0.47 -6.79 -0.35 5.2e-11 Longevity;Endometriosis; LUSC cis rs3106136 0.527 rs2664872 chr4:95146952 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.35 -0.42 1.88e-15 Capecitabine sensitivity; LUSC cis rs2692947 0.794 rs2692949 chr2:96673525 G/A cg23100626 chr2:96804247 ASTL 0.25 6.2 0.32 1.66e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.96 0.31 6.37e-9 Rheumatoid arthritis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26808979 chr11:16759946 C11orf58 -0.43 -6.25 -0.32 1.24e-9 Electrocardiographic conduction measures; LUSC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg23283495 chr1:209979779 IRF6 0.44 7.16 0.36 5.23e-12 Monobrow; LUSC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg24675056 chr1:15929824 NA 0.45 7.81 0.39 7.42e-14 Systolic blood pressure; LUSC cis rs1790761 0.658 rs684928 chr11:67329742 G/A cg08355456 chr11:67383691 NA 0.37 6.87 0.35 3.21e-11 Mean corpuscular volume; LUSC cis rs11098499 0.954 rs7437420 chr4:120312903 A/G cg24375607 chr4:120327624 NA 0.77 11.4 0.53 1.19e-25 Corneal astigmatism; LUSC cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg13319975 chr6:146136371 FBXO30 0.49 7.42 0.38 9.93e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1577917 0.771 rs2842612 chr6:86303091 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.88 -0.51 8.15e-24 Response to antipsychotic treatment; LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13732083 chr21:47605072 C21orf56 0.43 6.22 0.32 1.52e-9 Testicular germ cell tumor; LUSC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.3 -0.41 2.62e-15 Lung cancer; LUSC cis rs11039100 0.920 rs11038963 chr11:5781361 A/G cg05234568 chr11:5960015 NA -0.52 -5.76 -0.3 1.88e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7584330 0.657 rs10190310 chr2:238352282 C/T cg14458575 chr2:238380390 NA 0.69 11.79 0.54 4.67e-27 Prostate cancer; LUSC cis rs965469 1.000 rs1331215 chr20:3376565 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.77 -0.3 1.78e-8 IFN-related cytopenia; LUSC cis rs1882538 0.538 rs9649587 chr7:133104569 A/C cg10665199 chr7:133106180 EXOC4 0.59 8.33 0.41 2.12e-15 Intelligence (multi-trait analysis); LUSC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg05535760 chr7:792225 HEATR2 0.94 9.96 0.48 1.29e-20 Cerebrospinal P-tau181p levels; LUSC cis rs72960926 0.744 rs56004196 chr6:74880673 G/A cg03266952 chr6:74778945 NA -0.8 -6.35 -0.33 7.23e-10 Metabolite levels (MHPG); LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg15112475 chr7:1198522 ZFAND2A -0.29 -5.87 -0.31 1.06e-8 Longevity;Endometriosis; LUSC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg12310025 chr6:25882481 NA -0.55 -9.09 -0.45 8.82e-18 Intelligence (multi-trait analysis); LUSC cis rs1018836 0.923 rs9643298 chr8:91552502 G/A cg16814680 chr8:91681699 NA -0.77 -13.26 -0.59 1.62e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs4689592 0.503 rs59640165 chr4:7051661 G/A cg07817883 chr1:32538562 TMEM39B 0.6 5.97 0.31 5.92e-9 Monocyte percentage of white cells; LUSC cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.82 0.3 1.37e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14240646 chr10:27532245 ACBD5 -0.65 -7.75 -0.39 1.15e-13 Breast cancer; LUSC cis rs2425143 0.547 rs6141583 chr20:34572834 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.01 -0.31 4.74e-9 Blood protein levels; LUSC cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs72781680 0.898 rs17462670 chr2:24026579 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs1348850 0.874 rs952746 chr2:178306584 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.85 0.39 5.73e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg09888156 chr4:140222272 NAA15 0.43 7.09 0.36 8.19e-12 Triglycerides; LUSC cis rs6430585 0.583 rs60253740 chr2:136571852 G/T cg07169764 chr2:136633963 MCM6 1.15 16.94 0.68 7.04e-47 Corneal structure; LUSC cis rs3784262 0.934 rs7164408 chr15:58259336 A/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.66 -0.3 3.24e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs12681288 0.676 rs2701913 chr8:999982 A/T cg15309053 chr8:964076 NA 0.39 7.94 0.4 3.15e-14 Schizophrenia; LUSC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg25427524 chr10:38739819 LOC399744 0.68 12.19 0.55 1.65e-28 Extrinsic epigenetic age acceleration; LUSC cis rs6121246 0.529 rs6060174 chr20:30183538 G/A cg21427119 chr20:30132790 HM13 -0.44 -6.25 -0.32 1.23e-9 Mean corpuscular hemoglobin; LUSC cis rs950169 0.881 rs72750843 chr15:85135783 C/T cg17173187 chr15:85201210 NMB 0.37 6.31 0.33 9.02e-10 Schizophrenia; LUSC cis rs6500395 1.000 rs9933329 chr16:48646572 T/C cg04672837 chr16:48644449 N4BP1 0.48 7.15 0.36 5.54e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7851660 0.874 rs10120412 chr9:100628238 T/C cg13688889 chr9:100608707 NA -0.56 -8.89 -0.44 3.89e-17 Strep throat; LUSC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg23758822 chr17:41437982 NA 1.02 18.36 0.71 1.55e-52 Menopause (age at onset); LUSC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg10792982 chr14:105748885 BRF1 0.5 9.08 0.44 9.76e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs11190604 1.000 rs2495754 chr10:102324812 C/T cg16342193 chr10:102329863 NA -0.38 -6.43 -0.33 4.33e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6840360 0.967 rs7695162 chr4:152510541 G/A cg22705602 chr4:152727874 NA -0.28 -5.99 -0.31 5.3300000000000004e-09 Intelligence (multi-trait analysis); LUSC trans rs62238980 0.521 rs78578916 chr22:32456881 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg02951883 chr7:2050386 MAD1L1 -0.39 -6.65 -0.34 1.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.870 rs3733338 chr4:1241472 G/A cg02018176 chr4:1364513 KIAA1530 0.45 7.73 0.39 1.3e-13 Obesity-related traits; LUSC cis rs12618769 0.597 rs3769738 chr2:99078367 T/C cg10123293 chr2:99228465 UNC50 0.45 7.68 0.39 1.72e-13 Bipolar disorder; LUSC cis rs748404 0.697 rs504417 chr15:43554226 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.88 0.31 1e-8 Lung cancer; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg22963979 chr7:1858916 MAD1L1 -0.61 -9.58 -0.46 2.24e-19 Bipolar disorder and schizophrenia; LUSC cis rs950169 0.887 rs71395453 chr15:85113490 G/C cg17507749 chr15:85114479 UBE2QP1 0.71 9.38 0.46 1.02e-18 Schizophrenia; LUSC trans rs11039798 0.588 rs666165 chr11:48457439 C/T cg15704280 chr7:45808275 SEPT13 -0.59 -6.38 -0.33 6e-10 Axial length; LUSC cis rs1048238 0.506 rs56352596 chr1:16297592 G/A cg21385522 chr1:16154831 NA 0.56 8.53 0.42 5.15e-16 Systolic blood pressure; LUSC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg06634786 chr22:41940651 POLR3H 0.49 5.72 0.3 2.34e-8 Vitiligo; LUSC cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg06547715 chr2:218990976 CXCR2 0.34 6.55 0.34 2.2e-10 Ulcerative colitis; LUSC cis rs6456156 0.846 rs7774396 chr6:167519786 G/A cg07741184 chr6:167504864 NA 0.37 6.45 0.33 3.82e-10 Primary biliary cholangitis; LUSC cis rs41271951 0.512 rs12068365 chr1:151015868 G/A cg11822372 chr1:151115635 SEMA6C -0.8 -7.4 -0.38 1.09e-12 Blood protein levels; LUSC trans rs12310956 0.510 rs1825903 chr12:33870437 G/C cg26384229 chr12:38710491 ALG10B 0.56 8.69 0.43 1.69e-16 Morning vs. evening chronotype; LUSC cis rs4631830 0.720 rs898343 chr10:51505403 A/G cg20129853 chr10:51489980 NA 0.36 7.53 0.38 4.63e-13 Prostate-specific antigen levels; LUSC cis rs4237845 0.537 rs9645819 chr12:58270063 T/C cg02175503 chr12:58329896 NA 0.45 6.6 0.34 1.63e-10 Intelligence (multi-trait analysis); LUSC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg02503808 chr4:7069936 GRPEL1 1.04 14.24 0.61 2.84e-36 Monocyte percentage of white cells; LUSC cis rs875971 0.660 rs10229345 chr7:65982168 G/C cg18876405 chr7:65276391 NA 0.71 12.42 0.56 2.14e-29 Aortic root size; LUSC cis rs11264799 0.765 rs7531547 chr1:157623267 G/T cg18268488 chr1:157545234 FCRL4 0.33 5.74 0.3 2.13e-8 IgA nephropathy; LUSC cis rs55882075 0.583 rs9637934 chr5:179114025 G/C cg14593053 chr5:179126677 CANX 0.39 6.08 0.32 3.24e-9 Monocyte percentage of white cells; LUSC cis rs10465746 0.780 rs4907190 chr1:84409168 T/C cg10977910 chr1:84465055 TTLL7 0.45 6.61 0.34 1.48e-10 Obesity-related traits; LUSC cis rs9648716 0.515 rs38740 chr7:140711275 G/A cg23214464 chr7:140373596 ADCK2 0.72 6.24 0.32 1.29e-9 Type 2 diabetes; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22227058 chr5:159846119 SLU7 -0.42 -6.29 -0.33 9.99e-10 Electrocardiographic conduction measures; LUSC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg24324837 chr19:49891574 CCDC155 0.49 6.25 0.32 1.23e-9 Multiple sclerosis; LUSC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg11062466 chr8:58055876 NA 0.68 7.85 0.39 5.73e-14 Developmental language disorder (linguistic errors); LUSC cis rs4499344 0.633 rs259282 chr19:33163043 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.77 11.79 0.54 4.82e-27 Mean platelet volume; LUSC cis rs1355223 0.583 rs2941041 chr11:34874734 A/C cg11058730 chr11:34937778 PDHX;APIP 0.69 11.11 0.52 1.27e-24 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg17143192 chr8:8559678 CLDN23 0.63 9.03 0.44 1.37e-17 Obesity-related traits; LUSC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg07741184 chr6:167504864 NA 0.39 7.04 0.36 1.12e-11 Crohn's disease; LUSC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg18876405 chr7:65276391 NA -0.6 -9.75 -0.47 6.36e-20 Aortic root size; LUSC trans rs10763170 0.646 rs11004720 chr10:56824723 G/A cg10538533 chr12:53074328 KRT1 0.3 6.05 0.31 3.91e-9 Sporadic pituitary adenoma; LUSC cis rs11779988 0.545 rs398806 chr8:17786226 T/C cg01800426 chr8:17659068 MTUS1 -0.47 -5.8 -0.3 1.53e-8 Breast cancer; LUSC cis rs6964587 1.000 rs2299232 chr7:91626699 A/C cg22709100 chr7:91322751 NA 0.41 5.98 0.31 5.75e-9 Breast cancer; LUSC trans rs7937682 0.855 rs521947 chr11:111492616 A/G cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs3087591 0.960 rs2066736 chr17:29559932 C/A cg24425628 chr17:29625626 OMG;NF1 -0.66 -9.85 -0.47 2.85e-20 Hip circumference; LUSC cis rs6714710 0.603 rs2278700 chr2:98427382 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs8017423 0.791 rs7146250 chr14:90711703 A/G cg04374321 chr14:90722782 PSMC1 0.74 11.68 0.54 1.12e-26 Mortality in heart failure; LUSC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg18904891 chr8:8559673 CLDN23 0.58 8.18 0.41 6.1e-15 Obesity-related traits; LUSC cis rs6754311 0.593 rs313522 chr2:136430866 T/A cg07169764 chr2:136633963 MCM6 0.55 7.29 0.37 2.32e-12 Mosquito bite size; LUSC trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs6430585 0.528 rs111682961 chr2:136653848 C/T cg07169764 chr2:136633963 MCM6 1.2 17.53 0.69 3.07e-49 Corneal structure; LUSC cis rs11098499 0.663 rs28369503 chr4:120238925 G/A cg09307838 chr4:120376055 NA 0.71 10.61 0.5 7.43e-23 Corneal astigmatism; LUSC cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.27 -0.41 3.16e-15 Schizophrenia; LUSC cis rs9527 0.590 rs11191547 chr10:104843148 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.77 -0.35 5.8200000000000003e-11 Arsenic metabolism; LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg21724239 chr8:58056113 NA 0.79 9.39 0.46 9.94e-19 Developmental language disorder (linguistic errors); LUSC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg20243544 chr17:37824526 PNMT 0.49 6.9 0.35 2.55e-11 Asthma; LUSC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg04553112 chr3:125709451 NA -0.5 -5.7 -0.3 2.7e-8 Blood pressure (smoking interaction); LUSC cis rs896543 0.702 rs6711222 chr2:237494444 C/T cg25295825 chr2:237489920 CXCR7 0.52 6.38 0.33 5.74e-10 Alcohol dependence (age at onset); LUSC cis rs62064224 0.658 rs62065460 chr17:30715007 A/G cg18200150 chr17:30822561 MYO1D 0.51 10.29 0.49 9.6e-22 Schizophrenia; LUSC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg09034736 chr1:150693464 HORMAD1 0.42 5.91 0.31 8.53e-9 Melanoma; LUSC cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg07606381 chr6:8435919 SLC35B3 0.72 12.18 0.55 1.76e-28 Motion sickness; LUSC trans rs2243480 1.000 rs383402 chr7:65586653 A/C cg10756647 chr7:56101905 PSPH -0.8 -8.22 -0.41 4.61e-15 Diabetic kidney disease; LUSC cis rs17270561 0.609 rs9358879 chr6:25742918 C/G cg16482183 chr6:26056742 HIST1H1C 0.63 9.07 0.44 1.01e-17 Iron status biomarkers; LUSC cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -1.0 -18.84 -0.72 1.94e-54 Chronic sinus infection; LUSC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg12463550 chr7:65579703 CRCP -0.58 -8.61 -0.43 2.93e-16 Aortic root size; LUSC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.47 0.33 3.59e-10 Lung cancer; LUSC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.11e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7188861 0.626 rs7193871 chr16:11455606 C/G cg00044050 chr16:11439710 C16orf75 0.66 10.21 0.49 1.82e-21 HDL cholesterol; LUSC cis rs929596 0.639 rs7571915 chr2:234586574 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.87 -0.4 4.9e-14 Total bilirubin levels in HIV-1 infection; LUSC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC trans rs8073060 0.586 rs72829927 chr17:34049992 A/G cg19694781 chr19:47549865 TMEM160 1.14 18.04 0.7 2.84e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg22823121 chr1:150693482 HORMAD1 0.58 8.81 0.43 7.13e-17 Tonsillectomy; LUSC cis rs7180079 1.000 rs59190688 chr15:64516669 G/A cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs2996428 0.667 rs11576900 chr1:3770914 A/G cg17848003 chr1:3704513 LRRC47 0.31 5.75 0.3 2.03e-8 Red cell distribution width; LUSC cis rs2290416 0.579 rs58573550 chr8:144681714 G/A cg08017634 chr8:144659831 NAPRT1 0.72 6.17 0.32 2.03e-9 Attention deficit hyperactivity disorder; LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg22166914 chr1:53195759 ZYG11B 0.42 6.88 0.35 3.02e-11 Monocyte count; LUSC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg26380479 chr7:97908229 NA -0.27 -6.14 -0.32 2.28e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg21643547 chr1:205240462 TMCC2 -0.51 -9.75 -0.47 6.39e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1348850 0.608 rs10176632 chr2:178225934 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.88 0.31 1.02e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9311676 0.632 rs11924677 chr3:58420542 T/C cg13750441 chr3:58318267 PXK 0.35 6.83 0.35 4.14e-11 Systemic lupus erythematosus; LUSC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg02788857 chr8:22132959 PIWIL2 0.39 7.8 0.39 7.87e-14 Hypertriglyceridemia; LUSC cis rs62103177 0.564 rs1864529 chr18:77748975 G/A cg20368463 chr18:77673604 PQLC1 -0.63 -6.67 -0.34 1.09e-10 Opioid sensitivity; LUSC cis rs3020736 0.500 rs6519306 chr22:42501217 T/C cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs243505 0.965 rs243503 chr7:148436106 G/C cg09806900 chr7:148480153 CUL1 -0.48 -6.84 -0.35 3.71e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4343996 0.692 rs10258501 chr7:3460355 A/C cg21248987 chr7:3385318 SDK1 0.37 6.13 0.32 2.49e-9 Motion sickness; LUSC trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg08873628 chr1:175162347 KIAA0040 0.39 5.67 0.3 3.14e-8 Alcohol dependence; LUSC trans rs9944715 0.871 rs4890632 chr18:43826293 G/A cg01718231 chr17:29326311 RNF135 -0.48 -6.81 -0.35 4.41e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs77633900 0.772 rs506000 chr15:76817788 T/C cg21673338 chr15:77095150 SCAPER -0.71 -6.07 -0.32 3.44e-9 Non-glioblastoma glioma;Glioma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21830413 chr10:70884251 VPS26A -0.43 -6.33 -0.33 7.72e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.14 0.55 2.51e-28 Prudent dietary pattern; LUSC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg04352962 chr1:209979756 IRF6 0.53 6.46 0.33 3.78e-10 Cleft lip with or without cleft palate; LUSC cis rs911555 0.755 rs12432803 chr14:103930032 C/T cg24130564 chr14:104152367 KLC1 0.44 6.33 0.33 8.02e-10 Intelligence (multi-trait analysis); LUSC cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg27446573 chr6:127587934 RNF146 0.91 15.04 0.64 2.2e-39 Breast cancer; LUSC trans rs2204008 0.684 rs11514164 chr12:38036494 C/T cg06521331 chr12:34319734 NA -0.41 -6.45 -0.33 3.95e-10 Bladder cancer; LUSC cis rs10792830 0.706 rs565031 chr11:85671501 A/T cg07180834 chr11:85838833 NA -0.3 -5.76 -0.3 1.94e-8 Psychosis and Alzheimer's disease; LUSC cis rs7246967 0.673 rs73022713 chr19:22876222 G/C cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs16976116 0.901 rs28508034 chr15:55499010 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6445797 0.603 rs11130536 chr3:56668522 C/T cg13792233 chr3:56591045 CCDC66 0.41 5.72 0.3 2.33e-8 Gastritis; LUSC cis rs4363385 0.747 rs6671414 chr1:152974119 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.67 -0.3 3.15e-8 Inflammatory skin disease; LUSC cis rs7572644 0.766 rs6727432 chr2:28250990 T/G cg27432699 chr2:27873401 GPN1 -0.53 -6.58 -0.34 1.86e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs75518195 0.504 rs1449191 chr4:64881166 C/T cg01709288 chr16:81111226 C16orf46 -0.41 -6.02 -0.31 4.56e-9 Triptolide cytotoxicity; LUSC cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg17173187 chr15:85201210 NMB 0.48 9.22 0.45 3.42e-18 Schizophrenia; LUSC cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC cis rs2439831 0.850 rs68079546 chr15:44136957 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.54 0.42 4.94e-16 Lung cancer in ever smokers; LUSC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg22920501 chr2:26401640 FAM59B -0.74 -10.5 -0.5 1.83e-22 Gut microbiome composition (summer); LUSC cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg26384229 chr12:38710491 ALG10B -0.83 -15.88 -0.66 1.1e-42 Heart rate; LUSC cis rs10779751 0.770 rs4845853 chr1:11243470 A/G cg08854313 chr1:11322531 MTOR 0.87 14.1 0.61 9.84e-36 Body mass index; LUSC cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg03522245 chr20:25566470 NINL 0.36 5.84 0.3 1.24e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9303401 0.659 rs16943176 chr17:56769887 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs56399783 0.901 rs73049380 chr7:2832845 C/T cg14895029 chr7:2775587 GNA12 0.47 5.86 0.31 1.11e-8 Childhood ear infection; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg06877462 chr1:205807181 PM20D1 0.36 6.72 0.34 8.02e-11 Menarche (age at onset); LUSC cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg01689657 chr7:91764605 CYP51A1 0.32 5.66 0.3 3.34e-8 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11831004 chr1:52834260 NA -0.4 -6.12 -0.32 2.69e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7726839 0.574 rs72707007 chr5:661856 T/C cg11887960 chr12:57824829 NA 0.52 6.65 0.34 1.17e-10 Obesity-related traits; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg09177884 chr7:1199841 ZFAND2A -0.46 -6.11 -0.32 2.72e-9 Longevity;Endometriosis; LUSC cis rs4285028 0.699 rs12637968 chr3:121599976 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.81 -10.84 -0.51 1.19e-23 Multiple sclerosis; LUSC cis rs9322193 0.887 rs4870139 chr6:149896318 T/C cg04369109 chr6:150039330 LATS1 -0.52 -7.38 -0.37 1.27e-12 Lung cancer; LUSC cis rs10911251 0.546 rs2274984 chr1:183107446 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.7 -10.48 -0.5 2.13e-22 Colorectal cancer; LUSC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg06074448 chr4:187884817 NA -0.46 -7.68 -0.39 1.76e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1982963 1.000 rs904061 chr14:52504624 T/C cg10843707 chr14:52510701 NID2 -0.41 -6.57 -0.34 1.94e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg24675658 chr1:53192096 ZYG11B -0.75 -12.75 -0.57 1.31e-30 Monocyte count; LUSC cis rs7769051 0.522 rs73550455 chr6:133096633 A/G cg22852734 chr6:133119734 C6orf192 1.23 10.2 0.49 1.92e-21 Type 2 diabetes nephropathy; LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg03395511 chr6:291903 DUSP22 -0.48 -7.32 -0.37 1.82e-12 Menopause (age at onset); LUSC cis rs10908458 0.743 rs7367207 chr1:155079477 C/T cg23973274 chr1:155060172 NA -0.32 -6.24 -0.32 1.3e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4948102 0.961 rs7776550 chr7:56092391 T/C cg17215666 chr7:56131930 SUMF2 0.45 5.8 0.3 1.52e-8 Plasma homocysteine levels (post-methionine load test); LUSC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.33e-19 Menopause (age at onset); LUSC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs10740039 0.516 rs10740035 chr10:62352606 A/C cg18175470 chr10:62150864 ANK3 0.47 6.77 0.35 5.75e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7605827 0.930 rs7601661 chr2:15597409 A/G cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.55e-18 Educational attainment (years of education); LUSC cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg18681998 chr4:17616180 MED28 0.8 14.37 0.62 8.88e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12216125 0.801 rs56107510 chr6:25987436 C/A cg17691542 chr6:26056736 HIST1H1C 0.62 8.86 0.44 4.89e-17 Iron status biomarkers; LUSC cis rs6545883 0.894 rs6739427 chr2:61452879 T/C cg15711740 chr2:61764176 XPO1 0.43 6.74 0.35 7.14e-11 Tuberculosis; LUSC cis rs757081 0.667 rs17561348 chr11:17161615 C/T cg15432903 chr11:17409602 KCNJ11 0.36 5.67 0.3 3.14e-8 Systolic blood pressure; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg21782813 chr7:2030301 MAD1L1 0.49 8.32 0.41 2.34e-15 Bipolar disorder and schizophrenia; LUSC cis rs2282802 0.685 rs12188849 chr5:139621570 G/A cg26211634 chr5:139558579 C5orf32 0.44 8.27 0.41 3.12e-15 Intelligence (multi-trait analysis); LUSC cis rs7843479 0.601 rs11785043 chr8:21810377 C/T cg17168535 chr8:21777572 XPO7 0.84 15.18 0.64 6.22e-40 Mean corpuscular volume; LUSC trans rs4714291 0.832 rs9471247 chr6:40105318 A/G cg02267698 chr19:7991119 CTXN1 -0.52 -7.65 -0.39 2.11e-13 Strep throat; LUSC trans rs11098499 0.909 rs10014719 chr4:120320715 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.27e-9 Corneal astigmatism; LUSC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg06219351 chr7:158114137 PTPRN2 -0.52 -9.51 -0.46 3.88e-19 Calcium levels; LUSC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg16586182 chr3:47516702 SCAP -0.5 -7.91 -0.4 3.84e-14 Colorectal cancer; LUSC cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg26384229 chr12:38710491 ALG10B 0.83 13.52 0.59 1.59e-33 Drug-induced liver injury (flucloxacillin); LUSC cis rs854765 0.583 rs62064156 chr17:17822480 C/T cg16928487 chr17:17741425 SREBF1 -0.44 -8.59 -0.43 3.27e-16 Total body bone mineral density; LUSC trans rs7786808 0.530 rs7785656 chr7:158184164 C/G cg02030672 chr11:45687055 CHST1 0.44 6.69 0.34 9.42e-11 Obesity-related traits; LUSC cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14442939 chr10:27389572 ANKRD26 -0.88 -9.91 -0.48 1.85e-20 Breast cancer; LUSC cis rs3768617 0.510 rs10911249 chr1:183080690 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.84 0.51 1.15e-23 Fuchs's corneal dystrophy; LUSC cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg23992470 chr4:843637 GAK 0.58 6.21 0.32 1.56e-9 Intelligence (multi-trait analysis); LUSC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.78 0.47 5.03e-20 Height; LUSC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg25039879 chr17:56429692 SUPT4H1 0.5 7.02 0.36 1.22e-11 Cognitive test performance; LUSC cis rs6987853 0.761 rs2923391 chr8:42415942 G/A cg09913449 chr8:42400586 C8orf40 0.53 9.21 0.45 3.73e-18 Mean corpuscular hemoglobin concentration; LUSC trans rs7786808 0.615 rs4909209 chr7:158194329 C/T cg02030672 chr11:45687055 CHST1 0.55 8.95 0.44 2.6e-17 Obesity-related traits; LUSC cis rs4889855 0.614 rs9892081 chr17:78484484 A/C cg00066239 chr17:78472159 NA 0.39 6.77 0.35 5.76e-11 Fractional excretion of uric acid; LUSC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg17328964 chr8:145687451 CYHR1 0.63 10.47 0.5 2.19e-22 Age at first birth; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg10150615 chr22:24372951 LOC391322 -0.42 -6.98 -0.36 1.61e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg03676636 chr4:99064102 C4orf37 0.36 7.94 0.4 3.02e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.930 rs10189180 chr2:15685949 T/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs7208859 0.623 rs9911490 chr17:29073013 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs7824557 0.564 rs7834572 chr8:11236685 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -7.47 -0.38 7.29e-13 Retinal vascular caliber; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg14004847 chr7:1930337 MAD1L1 -0.49 -7.41 -0.38 1.06e-12 Bipolar disorder and schizophrenia; LUSC cis rs7399018 0.739 rs7953955 chr12:51608467 A/G cg25754956 chr12:51612065 POU6F1 1.02 16.58 0.67 1.74e-45 Cisplatin-induced ototoxicity; LUSC cis rs11229555 1.000 rs10896795 chr11:58366561 A/G cg15696309 chr11:58395628 NA -0.69 -9.24 -0.45 2.95e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs7937682 0.883 rs1784776 chr11:111472392 C/T cg18187862 chr3:45730750 SACM1L 0.52 6.65 0.34 1.2e-10 Primary sclerosing cholangitis; LUSC cis rs9467773 0.967 rs7753565 chr6:26560012 A/G cg05738196 chr6:26577821 NA 0.83 16.08 0.66 1.69e-43 Intelligence (multi-trait analysis); LUSC trans rs11039798 0.764 rs76882342 chr11:48939091 A/T cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs17270561 0.609 rs7769908 chr6:25760539 G/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg20887711 chr4:1340912 KIAA1530 0.69 11.32 0.53 2.36e-25 Longevity; LUSC cis rs7829975 0.681 rs2271342 chr8:8643938 C/T cg01851573 chr8:8652454 MFHAS1 -0.35 -5.96 -0.31 6.33e-9 Mood instability; LUSC cis rs2235544 0.565 rs664848 chr1:54468321 C/T cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs4594175 0.926 rs4243570 chr14:51624243 C/T cg23942311 chr14:51606299 NA 0.31 5.88 0.31 1.01e-8 Cancer; LUSC cis rs6580649 0.883 rs4075913 chr12:48537624 A/G cg24011408 chr12:48396354 COL2A1 0.46 6.3 0.33 9.31e-10 Lung cancer; LUSC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg23711669 chr6:146136114 FBXO30 -0.91 -17.6 -0.69 1.62e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs826838 1.000 rs1393537 chr12:38920961 C/T cg13010199 chr12:38710504 ALG10B 0.68 11.24 0.52 4.28e-25 Heart rate; LUSC cis rs7666738 0.546 rs7679681 chr4:98882221 A/G cg17366294 chr4:99064904 C4orf37 0.53 8.39 0.42 1.38e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg09165964 chr15:75287851 SCAMP5 -1.07 -16.47 -0.67 4.95e-45 Blood trace element (Zn levels); LUSC cis rs870825 0.616 rs28579226 chr4:185650458 A/C cg04058563 chr4:185651563 MLF1IP 0.81 12.19 0.56 1.52e-28 Blood protein levels; LUSC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg21854759 chr1:92012499 NA -0.54 -9.07 -0.44 1.07e-17 Breast cancer; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg09177884 chr7:1199841 ZFAND2A -0.57 -7.61 -0.38 2.76e-13 Longevity;Endometriosis; LUSC cis rs9486719 1.000 rs2273622 chr6:97058567 A/G cg06623918 chr6:96969491 KIAA0776 -0.83 -10.13 -0.48 3.27e-21 Migraine;Coronary artery disease; LUSC cis rs870825 0.655 rs72703561 chr4:185630890 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.12 0.58 5.24e-32 Blood protein levels; LUSC cis rs3806843 0.548 rs246052 chr5:140326413 G/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs68170813 0.559 rs77422419 chr7:106957932 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.92e-21 Monocyte count; LUSC trans rs7103411 0.637 rs7116850 chr11:27645530 C/T cg15471856 chr13:19448839 NA -0.43 -6.29 -0.33 9.86e-10 Menarche (age at onset);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC trans rs61931739 0.534 rs1486886 chr12:34043619 C/T cg26384229 chr12:38710491 ALG10B 0.7 10.77 0.51 2.06e-23 Morning vs. evening chronotype; LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg03354898 chr7:1950403 MAD1L1 -0.32 -6.3 -0.33 9.32e-10 Bipolar disorder and schizophrenia; LUSC cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg22782873 chr19:19639568 YJEFN3 0.5 6.11 0.32 2.84e-9 Bipolar disorder; LUSC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg01448562 chr3:133502909 NA -0.54 -7.94 -0.4 3.16e-14 Iron status biomarkers; LUSC cis rs354225 0.584 rs13432302 chr2:54813938 A/C cg01766943 chr2:54829624 SPTBN1 0.54 8.71 0.43 1.45e-16 Schizophrenia; LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg02423579 chr7:2872169 GNA12 0.44 6.29 0.33 1.01e-9 Height; LUSC cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.53 0.46 3.48e-19 Menarche (age at onset); LUSC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg16680214 chr1:154839983 KCNN3 0.51 9.6 0.46 2.02e-19 Prostate cancer; LUSC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg14558114 chr2:88469736 THNSL2 -0.64 -8.79 -0.43 8.24e-17 Response to metformin (IC50); LUSC cis rs193541 0.632 rs30023 chr5:122285299 T/G cg19077854 chr5:122220652 SNX24 0.4 8.57 0.42 3.96e-16 Glucose homeostasis traits; LUSC cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.07 0.52 1.86e-24 Colorectal cancer; LUSC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg12463550 chr7:65579703 CRCP -0.45 -6.78 -0.35 5.38e-11 Cotinine glucuronidation; LUSC cis rs9733 0.744 rs4970976 chr1:150779524 T/A cg04414720 chr1:150670196 GOLPH3L -0.43 -6.89 -0.35 2.86e-11 Tonsillectomy; LUSC cis rs6489882 0.703 rs10850095 chr12:113360575 T/C cg20102336 chr12:113376681 OAS3 -0.4 -5.71 -0.3 2.46e-8 Chronic lymphocytic leukemia; LUSC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg06238570 chr21:40685208 BRWD1 -0.56 -8.55 -0.42 4.47e-16 Menarche (age at onset); LUSC cis rs1908814 0.516 rs56102998 chr8:11796675 G/A cg21775007 chr8:11205619 TDH 0.46 6.4 0.33 5.19e-10 Neuroticism; LUSC cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.26 0.37 2.66e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13108904 0.557 rs1250095 chr4:1239312 C/T cg05165339 chr4:1420672 NA 0.28 6.19 0.32 1.74e-9 Obesity-related traits; LUSC trans rs4518370 0.926 rs10061374 chr5:82173912 T/C cg14564229 chr9:119748106 ASTN2 -0.38 -5.97 -0.31 6.05e-9 Osteoarthritis biomarkers; LUSC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg06219351 chr7:158114137 PTPRN2 -0.51 -9.1 -0.45 8.56e-18 Calcium levels; LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg12016809 chr21:47604291 C21orf56 -0.45 -6.71 -0.34 8.23e-11 Testicular germ cell tumor; LUSC cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg16339924 chr4:17578868 LAP3 -0.55 -7.95 -0.4 2.87e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6733011 0.578 rs4851171 chr2:99510817 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.09 -0.36 8.28e-12 Bipolar disorder; LUSC cis rs1595825 0.945 rs7581202 chr2:198836777 A/G cg00982548 chr2:198649783 BOLL -0.58 -7.25 -0.37 2.87e-12 Ulcerative colitis; LUSC cis rs1215050 0.791 rs165254 chr4:98763564 C/T cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.25e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6598955 0.543 rs79778574 chr1:26538482 A/G cg04990556 chr1:26633338 UBXN11 0.85 11.14 0.52 9.76e-25 Obesity-related traits; LUSC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg08645402 chr16:4508243 NA 0.48 7.34 0.37 1.66e-12 Schizophrenia; LUSC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg20701182 chr2:24300061 SF3B14 -0.88 -11.39 -0.53 1.31e-25 Lymphocyte counts; LUSC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg15556689 chr8:8085844 FLJ10661 0.54 8.14 0.41 7.88e-15 Triglycerides; LUSC cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg17845761 chr1:175162550 KIAA0040 -0.32 -6.03 -0.31 4.41e-9 Alcohol dependence; LUSC cis rs1891275 0.515 rs2421694 chr10:93516104 A/G cg07889827 chr10:93443413 NA -0.4 -9.18 -0.45 4.78e-18 Intelligence (multi-trait analysis); LUSC trans rs7829975 0.572 rs7005000 chr8:8796602 A/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.28 -0.32 1.03e-9 Mood instability; LUSC cis rs8060686 0.641 rs75297764 chr16:68212820 C/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs11166629 1.000 rs7003870 chr8:135616586 A/G cg27224718 chr8:135614730 ZFAT 0.68 11.0 0.52 3.28e-24 Smoking quantity; LUSC cis rs17685 0.753 rs3757593 chr7:75678735 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.91 0.4 3.75e-14 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs1325195 0.920 rs2816203 chr1:179163857 T/C cg11624085 chr17:8464688 MYH10 0.41 6.64 0.34 1.29e-10 IgE grass sensitization; LUSC cis rs6121246 0.529 rs6088814 chr20:30218172 C/T cg21427119 chr20:30132790 HM13 -0.43 -6.1 -0.32 3.01e-9 Mean corpuscular hemoglobin; LUSC cis rs3740713 1.000 rs2643872 chr11:18450444 A/T cg23797887 chr11:18477753 LDHAL6A -0.58 -7.16 -0.36 5.04e-12 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9581857 0.556 rs9581864 chr13:28041567 T/C cg22138327 chr13:27999177 GTF3A 0.71 9.63 0.47 1.58e-19 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg01802117 chr1:53393560 SCP2 -0.39 -6.43 -0.33 4.29e-10 Monocyte count; LUSC cis rs1784581 0.588 rs7765624 chr6:162427462 C/A cg17173639 chr6:162384350 PARK2 0.57 9.89 0.48 2.12e-20 Itch intensity from mosquito bite; LUSC cis rs61931739 0.658 rs10772149 chr12:34285498 A/G cg06521331 chr12:34319734 NA -0.38 -6.64 -0.34 1.3e-10 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23186422 chr6:139013826 NA -0.41 -6.13 -0.32 2.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs259282 0.692 rs17693106 chr19:33125055 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.67 -10.31 -0.49 8.08e-22 Schizophrenia; LUSC cis rs7220401 0.789 rs4794859 chr17:27962393 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.54 -7.55 -0.38 4.15e-13 Coronary artery disease; LUSC cis rs1577917 0.837 rs806529 chr6:86467121 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.53 -0.42 5.22e-16 Response to antipsychotic treatment; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg21724239 chr8:58056113 NA 0.8 8.59 0.43 3.29e-16 Developmental language disorder (linguistic errors); LUSC trans rs11782517 0.920 rs4295669 chr8:10105427 C/A cg15556689 chr8:8085844 FLJ10661 0.49 5.95 0.31 6.62e-9 Nose size; LUSC cis rs7149337 0.805 rs2999357 chr14:51606001 C/G cg23942311 chr14:51606299 NA 0.49 11.44 0.53 8.92e-26 Cancer; LUSC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg03929089 chr4:120376271 NA -0.93 -16.14 -0.66 9.76e-44 Height; LUSC cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg18681998 chr4:17616180 MED28 0.86 15.74 0.65 3.96e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8014204 0.804 rs34956813 chr14:75254167 G/A cg06637938 chr14:75390232 RPS6KL1 0.65 10.68 0.5 4.38e-23 Caffeine consumption; LUSC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg14829155 chr15:31115871 NA 0.72 10.75 0.51 2.45e-23 Huntington's disease progression; LUSC trans rs1908814 0.510 rs7819276 chr8:11755804 T/C cg15556689 chr8:8085844 FLJ10661 -0.49 -6.28 -0.32 1.03e-9 Neuroticism; LUSC cis rs2274273 0.686 rs11624679 chr14:55624244 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.7 0.47 9.24e-20 Protein biomarker; LUSC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg20821713 chr7:1055600 C7orf50 -0.57 -7.34 -0.37 1.59e-12 Bronchopulmonary dysplasia; LUSC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.78 0.39 8.95e-14 Electroencephalogram traits; LUSC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg25427524 chr10:38739819 LOC399744 0.67 12.24 0.56 1.07e-28 Extrinsic epigenetic age acceleration; LUSC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg18681998 chr4:17616180 MED28 0.89 17.28 0.69 3.06e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17255340 0.539 rs1170519 chr6:84011961 C/G cg08257003 chr6:84140564 ME1 0.32 7.76 0.39 1.03e-13 Platelet-derived growth factor BB levels; LUSC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg22800045 chr5:56110881 MAP3K1 0.78 9.56 0.46 2.72e-19 Initial pursuit acceleration; LUSC cis rs35146811 0.735 rs1061230 chr7:99807265 G/A cg19116668 chr7:99932089 PMS2L1 0.33 5.83 0.3 1.28e-8 Coronary artery disease; LUSC cis rs988712 0.672 rs35038967 chr11:27703480 T/A cg10635145 chr11:27742435 BDNF -0.46 -6.06 -0.31 3.67e-9 Obesity; LUSC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg16447950 chr5:562315 NA -0.56 -6.9 -0.35 2.63e-11 Lung disease severity in cystic fibrosis; LUSC cis rs6674970 0.518 rs6587552 chr1:151018861 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 0.57 7.68 0.39 1.81e-13 Childhood ear infection; LUSC cis rs9902453 0.765 rs2628185 chr17:28070107 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.11 -0.52 1.32e-24 Coffee consumption (cups per day); LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg11494091 chr17:61959527 GH2 0.64 13.45 0.59 3.06e-33 Prudent dietary pattern; LUSC cis rs734999 0.967 rs6667605 chr1:2502780 C/T cg18854424 chr1:2615690 NA 0.47 9.77 0.47 5.59e-20 Ulcerative colitis; LUSC cis rs9457247 1.000 rs393727 chr6:167398632 T/A cg20406979 chr6:167373233 NA 0.26 6.13 0.32 2.5e-9 Crohn's disease; LUSC cis rs907612 0.638 rs907611 chr11:1874072 G/A cg05305434 chr11:1874049 LSP1 0.34 6.17 0.32 1.95e-9 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg00316803 chr15:76480434 C15orf27 0.4 7.09 0.36 7.81e-12 Blood metabolite levels; LUSC cis rs2658782 0.789 rs1456238 chr11:93117370 G/C cg15737290 chr11:93063684 CCDC67 0.61 7.46 0.38 7.34e-13 Pulmonary function decline; LUSC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg00825309 chr19:58991885 ZNF446 -0.5 -7.23 -0.37 3.27e-12 Uric acid clearance; LUSC cis rs9369695 0.842 rs2396825 chr6:47568696 A/G cg20196966 chr6:47445060 CD2AP 0.42 5.91 0.31 8.6e-9 Reticulocyte count; LUSC cis rs10979 0.965 rs9390111 chr6:143894272 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -12.25 -0.56 9.15e-29 Hypospadias; LUSC cis rs6545977 0.531 rs2539982 chr2:63111004 G/A cg17519650 chr2:63277830 OTX1 0.7 10.19 0.49 2.13e-21 Prostate cancer; LUSC trans rs853679 0.607 rs17763089 chr6:27835218 G/A cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.13e-9 Depression; LUSC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg15744005 chr10:104629667 AS3MT -0.28 -5.95 -0.31 6.91e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4561483 0.549 rs6498251 chr16:11952290 A/G cg08843971 chr16:11963173 GSPT1 0.44 6.66 0.34 1.1e-10 Testicular germ cell tumor; LUSC trans rs11039798 0.764 rs11040030 chr11:48800985 C/T cg15704280 chr7:45808275 SEPT13 0.78 7.46 0.38 7.71e-13 Axial length; LUSC cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg03146154 chr1:46216737 IPP 0.55 8.26 0.41 3.39e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg09365446 chr1:150670422 GOLPH3L 0.52 8.07 0.4 1.29e-14 Tonsillectomy; LUSC cis rs4780401 0.782 rs933573 chr16:11793395 A/G cg01061890 chr16:11836724 TXNDC11 0.42 6.06 0.31 3.63e-9 Rheumatoid arthritis; LUSC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg23590916 chr17:43697445 MGC57346 0.5 6.69 0.34 9.18e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs17125944 0.542 rs75723366 chr14:53256882 T/C cg13660082 chr14:53194042 PSMC6 -0.74 -6.4 -0.33 5.22e-10 Alzheimer's disease (late onset); LUSC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg19467586 chr17:45266599 CDC27 0.39 5.97 0.31 6.01e-9 Calcium levels; LUSC cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs7584330 0.554 rs6760890 chr2:238400645 G/A cg14458575 chr2:238380390 NA 0.69 8.36 0.42 1.7e-15 Prostate cancer; LUSC cis rs9517320 0.534 rs9554477 chr13:99160379 C/T cg20487152 chr13:99095054 FARP1 -0.36 -6.33 -0.33 8.12e-10 Longevity; LUSC cis rs9467773 1.000 rs9467783 chr6:26542894 C/T cg05738196 chr6:26577821 NA 0.82 15.82 0.65 1.78e-42 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.818 rs407103 chr1:153007106 C/T cg25856811 chr1:152973957 SPRR3 0.34 5.68 0.3 2.9e-8 Inflammatory skin disease; LUSC cis rs7523273 0.548 rs2724381 chr1:207949017 T/C cg22525895 chr1:207977042 MIR29B2 0.42 6.77 0.35 5.95e-11 Schizophrenia; LUSC cis rs9815354 0.812 rs55916855 chr3:42002761 A/G cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs7098414 0.530 rs4146515 chr10:82116602 G/A cg01528321 chr10:82214614 TSPAN14 0.64 9.56 0.46 2.72e-19 Post bronchodilator FEV1; LUSC cis rs7829975 0.684 rs474892 chr8:8596731 G/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.23 -0.37 3.34e-12 Mood instability; LUSC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg04450456 chr4:17643702 FAM184B 0.42 7.04 0.36 1.07e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg11764359 chr7:65958608 NA 0.55 7.04 0.36 1.07e-11 Aortic root size; LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.76 -0.3 1.89e-8 Developmental language disorder (linguistic errors); LUSC cis rs9837602 1.000 rs704582 chr3:99571926 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.52 6.71 0.34 8.27e-11 Breast cancer; LUSC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.62 10.14 0.49 3.07e-21 Lymphocyte counts; LUSC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11644478 chr21:40555479 PSMG1 -0.66 -10.21 -0.49 1.71e-21 Menarche (age at onset); LUSC trans rs1973993 0.669 rs510552 chr1:96891671 A/G cg10631902 chr5:14652156 NA 0.61 10.9 0.51 7.43e-24 Weight; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg13397359 chr6:42928475 GNMT 0.67 11.61 0.54 2.06e-26 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11785693 0.862 rs62491196 chr8:4995690 C/T cg26367366 chr8:4980734 NA 0.73 8.62 0.43 2.77e-16 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.68 10.3 0.49 8.47e-22 Monocyte percentage of white cells; LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg01879757 chr17:41196368 BRCA1 -0.45 -6.98 -0.36 1.58e-11 Menopause (age at onset); LUSC cis rs12136530 0.744 rs12090885 chr1:19779781 G/A cg01832549 chr1:19774989 CAPZB -0.32 -5.85 -0.31 1.14e-8 Lead levels in blood; LUSC cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.47 -0.33 3.45e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.9 -0.35 2.54e-11 Platelet count; LUSC trans rs1998174 0.509 rs742509 chr1:171826694 G/A cg13482142 chr2:234261155 NA 0.42 6.07 0.32 3.47e-9 Platelet distribution width; LUSC cis rs7100689 0.622 rs2994389 chr10:82062257 C/G cg00277334 chr10:82204260 NA -0.58 -8.65 -0.43 2.21e-16 Post bronchodilator FEV1; LUSC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg07424592 chr7:64974309 NA 0.67 5.88 0.31 9.74e-9 Diabetic kidney disease; LUSC cis rs698813 0.674 rs713447 chr2:44505185 T/G cg00619915 chr2:44497795 NA -0.5 -6.66 -0.34 1.1e-10 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs1909881 1.000 rs3104903 chr8:96509113 C/T cg04203453 chr8:96504381 NA -0.32 -5.66 -0.3 3.3e-8 Obesity-related traits; LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs2227930 0.506 rs13082648 chr3:142129008 C/T cg16271453 chr3:142027066 XRN1 -0.55 -9.72 -0.47 7.86e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs6977660 1.000 rs35784097 chr7:19818848 A/G cg07541023 chr7:19748670 TWISTNB 0.51 5.82 0.3 1.37e-8 Thyroid stimulating hormone; LUSC trans rs12579753 1.000 rs7956826 chr12:82173365 A/G cg07923666 chr12:49932857 KCNH3 -0.48 -5.96 -0.31 6.3e-9 Resting heart rate; LUSC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg06600287 chr1:53387719 ECHDC2 -0.29 -6.1 -0.32 3.01e-9 Monocyte count; LUSC cis rs782590 0.902 rs3762513 chr2:55762957 C/T cg18811423 chr2:55921094 PNPT1 0.82 14.27 0.62 2.17e-36 Metabolic syndrome; LUSC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -11.77 -0.54 5.5e-27 Extrinsic epigenetic age acceleration; LUSC trans rs7613875 0.600 rs2624832 chr3:50030858 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.48 7.58 0.38 3.38e-13 Body mass index; LUSC cis rs9309473 1.000 rs7585004 chr2:73666645 C/G cg20560298 chr2:73613845 ALMS1 -0.47 -6.63 -0.34 1.34e-10 Metabolite levels; LUSC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg25019033 chr10:957182 NA 0.53 8.55 0.42 4.61e-16 Eosinophil percentage of granulocytes; LUSC cis rs9311676 0.656 rs62258140 chr3:58407083 C/T cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.1e-10 Systemic lupus erythematosus; LUSC cis rs664172 1 rs664172 chr15:78862762 G/A cg24631222 chr15:78858424 CHRNA5 0.68 9.07 0.44 1.02e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -10.04 -0.48 6.81e-21 Glomerular filtration rate (creatinine); LUSC cis rs7246657 0.941 rs7256130 chr19:37933981 T/C cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs7772486 0.875 rs2748485 chr6:146332421 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.27 -0.37 2.65e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs12190007 0.512 rs2984464 chr6:169837242 T/C ch.6.169577133F chr6:169835210 NA -0.4 -6.08 -0.32 3.33e-9 Obesity-related traits; LUSC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg05425664 chr17:57184151 TRIM37 -0.56 -8.29 -0.41 2.82e-15 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg05347473 chr6:146136440 FBXO30 0.56 9.63 0.47 1.59e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs17095355 0.818 rs2501575 chr10:111849864 C/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.69 -0.39 1.72e-13 Biliary atresia; LUSC cis rs1728785 1.000 rs1728773 chr16:68563644 A/C cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC trans rs6076960 0.684 rs3909041 chr20:6249598 C/G cg21095983 chr6:86352623 SYNCRIP 0.49 7.39 0.37 1.16e-12 Smooth-surface caries; LUSC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg18252515 chr7:66147081 NA -1.24 -13.99 -0.61 2.59e-35 Diabetic kidney disease; LUSC trans rs11098499 0.954 rs12499324 chr4:120393786 C/T cg25214090 chr10:38739885 LOC399744 0.6 8.81 0.43 6.84e-17 Corneal astigmatism; LUSC cis rs12908161 0.959 rs62019472 chr15:85331493 A/G cg12863693 chr15:85201151 NMB 0.4 8.02 0.4 1.79e-14 Schizophrenia; LUSC trans rs4332037 0.901 rs11767040 chr7:1945468 C/T cg10840412 chr1:235813424 GNG4 0.68 9.13 0.45 6.93e-18 Bipolar disorder; LUSC cis rs10089 0.953 rs2190797 chr5:127352875 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 11.98 0.55 9.02e-28 Ileal carcinoids; LUSC cis rs9462027 0.628 rs6925623 chr6:34800896 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.03 -0.31 4.26e-9 Systemic lupus erythematosus; LUSC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.65 0.57 3.19e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7937682 0.883 rs1611989 chr11:111456299 A/G cg11344533 chr11:111475393 SIK2 -0.46 -6.35 -0.33 6.87e-10 Primary sclerosing cholangitis; LUSC trans rs1325195 0.920 rs434283 chr1:179224180 T/C cg11624085 chr17:8464688 MYH10 0.41 6.68 0.34 9.91e-11 IgE grass sensitization; LUSC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg22105103 chr4:187893119 NA 0.72 14.07 0.61 1.2e-35 Lobe attachment (rater-scored or self-reported); LUSC trans rs7647973 0.626 rs9829155 chr3:49817450 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.6 7.1 0.36 7.44e-12 Menarche (age at onset); LUSC cis rs1577917 0.917 rs1838959 chr6:86556804 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.96e-29 Prudent dietary pattern; LUSC cis rs10028773 0.556 rs4473640 chr4:120260437 G/A cg09307838 chr4:120376055 NA 0.65 9.84 0.47 3.09e-20 Educational attainment; LUSC cis rs9341808 0.718 rs9443734 chr6:80820293 C/T cg08355045 chr6:80787529 NA 0.56 9.59 0.46 2.06e-19 Sitting height ratio; LUSC cis rs1153858 0.945 rs2467854 chr15:45701597 A/G cg26924012 chr15:45694286 SPATA5L1 1.1 19.11 0.72 1.62e-55 Homoarginine levels; LUSC cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg13010199 chr12:38710504 ALG10B 0.68 11.49 0.53 5.71e-26 Heart rate; LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg08200582 chr11:442649 ANO9 0.53 6.09 0.32 3.1e-9 Body mass index; LUSC trans rs1493916 0.905 rs4799727 chr18:31393095 T/G cg27147174 chr7:100797783 AP1S1 -0.66 -10.66 -0.5 4.82e-23 Life satisfaction; LUSC trans rs208520 0.690 rs12192710 chr6:66718137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.83 0.68 1.9e-46 Exhaled nitric oxide output; LUSC cis rs921968 0.565 rs3821035 chr2:219620223 T/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs11264799 0.765 rs66931510 chr1:157635085 C/T cg18268488 chr1:157545234 FCRL4 0.33 5.8 0.3 1.51e-8 IgA nephropathy; LUSC trans rs77724872 0.655 rs7137145 chr12:104780482 C/G cg10940549 chr15:45494721 SHF -0.67 -6.11 -0.32 2.79e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs7267979 0.966 rs3827014 chr20:25371559 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2130392 1.000 rs11132254 chr4:185611592 G/T cg04058563 chr4:185651563 MLF1IP 0.47 7.81 0.39 7.71e-14 Kawasaki disease; LUSC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg03609598 chr5:56110824 MAP3K1 -0.41 -6.14 -0.32 2.39e-9 Initial pursuit acceleration; LUSC cis rs7580658 0.929 rs11886231 chr2:128028130 G/A cg09760422 chr2:128146352 NA -0.32 -7.05 -0.36 1.02e-11 Protein C levels; LUSC cis rs6845621 0.700 rs2215762 chr4:18910602 A/G cg12196642 chr4:18937545 NA -0.33 -6.27 -0.32 1.1e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs11785400 0.793 rs6996760 chr8:143722386 G/A cg10596483 chr8:143751796 JRK 0.52 7.41 0.38 1.04e-12 Schizophrenia; LUSC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.74 0.35 6.78e-11 Tonsillectomy; LUSC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg18876405 chr7:65276391 NA 0.52 7.8 0.39 8e-14 Aortic root size; LUSC cis rs6845621 0.835 rs10030640 chr4:18943713 A/C cg12196642 chr4:18937545 NA 0.34 6.7 0.34 8.89e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs12824058 0.831 rs11608406 chr12:130805866 G/C cg24838063 chr12:130822603 PIWIL1 0.68 10.48 0.5 2.08e-22 Menopause (age at onset); LUSC cis rs2282032 1.000 rs56015111 chr14:90768946 G/A cg14092571 chr14:90743983 NA 0.53 6.85 0.35 3.54e-11 Longevity; LUSC cis rs9311676 0.656 rs11917567 chr3:58382254 C/T cg13750441 chr3:58318267 PXK 0.35 6.67 0.34 1.07e-10 Systemic lupus erythematosus; LUSC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg17264618 chr3:40429014 ENTPD3 0.29 6.46 0.33 3.61e-10 Renal cell carcinoma; LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg18099408 chr3:52552593 STAB1 -0.42 -7.07 -0.36 9.23e-12 Bipolar disorder; LUSC cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg26384229 chr12:38710491 ALG10B 0.93 15.88 0.66 1.1e-42 Bladder cancer; LUSC cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC trans rs61931739 0.534 rs2220547 chr12:34106255 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.29 0.41 2.82e-15 Morning vs. evening chronotype; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg26304593 chr6:42947056 PEX6 -0.49 -7.42 -0.38 9.65e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg16339924 chr4:17578868 LAP3 0.53 8.13 0.41 8.2e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9611565 0.649 rs139553 chr22:42187199 A/G cg03806693 chr22:41940476 POLR3H 0.82 12.06 0.55 4.79e-28 Vitiligo; LUSC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg21573476 chr21:45109991 RRP1B -0.36 -5.83 -0.3 1.31e-8 Mean corpuscular volume; LUSC trans rs6582630 0.502 rs4309219 chr12:38293584 A/G cg06521331 chr12:34319734 NA -0.42 -6.53 -0.34 2.48e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs10876993 0.928 rs10082911 chr12:58104104 C/A cg15848620 chr12:58087721 OS9 -0.56 -7.94 -0.4 3.09e-14 Celiac disease or Rheumatoid arthritis; LUSC trans rs3774749 0.565 rs2518796 chr3:50207075 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.44 6.68 0.34 9.71e-11 Intelligence (multi-trait analysis); LUSC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg11965913 chr1:205819406 PM20D1 0.45 6.57 0.34 1.98e-10 Parkinson's disease; LUSC cis rs10419226 0.555 rs757350 chr19:18774810 G/A cg22001208 chr19:18782374 NA -0.37 -6.14 -0.32 2.37e-9 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs4596713 0.568 rs10122932 chr9:71746053 C/G cg25283916 chr1:242222868 NA -0.3 -6.31 -0.33 8.74e-10 Headache; LUSC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg02079420 chr8:82753780 SNX16 -0.38 -5.79 -0.3 1.64e-8 Diastolic blood pressure; LUSC trans rs2262909 0.962 rs408687 chr19:22231123 T/C cg05197062 chr11:11642011 GALNTL4 -0.56 -7.81 -0.39 7.34e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg04287289 chr16:89883240 FANCA -0.78 -13.72 -0.6 2.85e-34 Vitiligo; LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.49 5.98 0.31 5.7e-9 Renal function-related traits (BUN); LUSC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg21724239 chr8:58056113 NA 0.77 7.96 0.4 2.67e-14 Developmental language disorder (linguistic errors); LUSC cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs895636 1.000 rs895636 chr2:45188353 A/G cg03867797 chr12:110939833 VPS29;RAD9B -0.46 -6.05 -0.31 3.86e-9 Metabolite levels;Fasting plasma glucose; LUSC cis rs2901656 0.544 rs6658843 chr1:172399082 G/C cg03748243 chr1:172413542 C1orf105;PIGC 0.31 6.27 0.32 1.15e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs78456975 1.000 rs13431491 chr2:1553808 T/A cg01028140 chr2:1542097 TPO -0.62 -7.98 -0.4 2.43e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs427394 0.582 rs4701751 chr5:6704137 C/T cg10857441 chr5:6722123 POLS -0.43 -7.79 -0.39 8.4e-14 Menopause (age at onset); LUSC trans rs12579753 0.879 rs12579544 chr12:82164043 A/C cg07923666 chr12:49932857 KCNH3 -0.47 -6.27 -0.32 1.14e-9 Resting heart rate; LUSC cis rs1483890 0.851 rs6762186 chr3:69402923 T/G cg22125112 chr3:69402811 FRMD4B 0.39 5.85 0.3 1.18e-8 Resting heart rate; LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg23758822 chr17:41437982 NA 1.04 19.44 0.73 7.67e-57 Menopause (age at onset); LUSC cis rs2732480 0.500 rs1387257 chr12:48636666 C/A cg04545296 chr12:48745243 ZNF641 0.33 6.02 0.31 4.65e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg21573476 chr21:45109991 RRP1B -0.42 -6.68 -0.34 1.03e-10 Coronary artery disease; LUSC cis rs829883 0.902 rs1620317 chr12:98890566 T/C cg25150519 chr12:98850993 NA 0.64 9.84 0.47 3.15e-20 Colorectal adenoma (advanced); LUSC cis rs929354 1.000 rs1182389 chr7:157038803 C/T cg05182265 chr7:156933206 UBE3C -0.49 -7.37 -0.37 1.37e-12 Body mass index; LUSC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.56 -0.38 3.87e-13 Aortic root size; LUSC cis rs79387448 0.745 rs72993760 chr2:103151704 G/A cg09003973 chr2:102972529 NA 0.86 8.44 0.42 9.66e-16 Gut microbiota (bacterial taxa); LUSC cis rs4664304 0.620 rs4665125 chr2:160714314 C/G cg23995753 chr2:160760732 LY75 0.3 5.64 0.3 3.56e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC cis rs427941 1.000 rs423452 chr7:101848790 G/A cg06246474 chr7:101738831 CUX1 -0.35 -5.65 -0.3 3.45e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs11018904 0.906 rs61903722 chr11:89967042 C/T cg26138821 chr11:89956704 CHORDC1 -0.6 -7.3 -0.37 2.15e-12 Intelligence (multi-trait analysis); LUSC cis rs9790314 1.000 rs336583 chr3:161081981 A/T cg03342759 chr3:160939853 NMD3 0.52 8.74 0.43 1.15e-16 Morning vs. evening chronotype; LUSC cis rs561341 0.700 rs8079471 chr17:30218317 A/G cg13647721 chr17:30228624 UTP6 0.69 8.47 0.42 7.83e-16 Hip circumference adjusted for BMI; LUSC cis rs9457247 0.765 rs9457256 chr6:167436461 T/C cg07741184 chr6:167504864 NA 0.42 7.54 0.38 4.41e-13 Crohn's disease; LUSC cis rs6964587 1.000 rs9691325 chr7:91731047 G/A cg17063962 chr7:91808500 NA 0.58 9.14 0.45 6.01e-18 Breast cancer; LUSC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg18230493 chr5:56204884 C5orf35 -0.96 -14.17 -0.61 4.9e-36 Initial pursuit acceleration; LUSC cis rs861020 0.959 rs641348 chr1:209992043 A/G cg05527609 chr1:210001259 C1orf107 0.94 12.15 0.55 2.3e-28 Orofacial clefts; LUSC trans rs10802346 0.545 rs12134404 chr1:246372144 A/G cg13514129 chr1:39547527 MACF1 0.71 11.79 0.54 4.48e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs1865760 0.602 rs9467662 chr6:26021327 G/A cg16482183 chr6:26056742 HIST1H1C 0.5 7.28 0.37 2.43e-12 Height; LUSC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg12463550 chr7:65579703 CRCP 0.57 8.52 0.42 5.72e-16 Aortic root size; LUSC trans rs8040855 0.894 rs6496770 chr15:85705121 T/A cg00988175 chr11:59481031 OR10V1 -0.28 -5.96 -0.31 6.57e-9 Bulimia nervosa; LUSC cis rs17767294 0.708 rs34957169 chr6:27879397 T/C cg08851530 chr6:28072375 NA 1.3 8.14 0.41 7.69e-15 Parkinson's disease; LUSC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg09703963 chr11:616879 IRF7;MUPCDH -0.43 -6.7 -0.34 9.04e-11 Systemic lupus erythematosus; LUSC cis rs9640161 0.711 rs10259796 chr7:150050427 T/C cg21361702 chr7:150065534 REPIN1 0.57 8.15 0.41 7.39e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.45 -0.42 9.36e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg13319975 chr6:146136371 FBXO30 0.46 7.11 0.36 7.11e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg11764359 chr7:65958608 NA -0.7 -10.79 -0.51 1.7e-23 Aortic root size; LUSC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg09509183 chr1:209979624 IRF6 0.43 5.73 0.3 2.25e-8 Cleft lip with or without cleft palate; LUSC cis rs734999 0.967 rs4486391 chr1:2513055 A/T cg18854424 chr1:2615690 NA 0.49 10.32 0.49 7.46e-22 Ulcerative colitis; LUSC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11644478 chr21:40555479 PSMG1 -0.66 -10.25 -0.49 1.27e-21 Menarche (age at onset); LUSC cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg24642439 chr20:33292090 TP53INP2 0.48 7.33 0.37 1.8e-12 Glomerular filtration rate (creatinine); LUSC cis rs9868809 0.881 rs2276850 chr3:48669648 G/A cg00383909 chr3:49044727 WDR6 1.07 9.61 0.47 1.86e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs62238980 0.522 rs79367011 chr22:32450245 G/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC trans rs4650994 0.525 rs2224811 chr1:178544323 C/T cg05059571 chr16:84539110 KIAA1609 0.47 8.95 0.44 2.49e-17 HDL cholesterol levels;HDL cholesterol; LUSC trans rs453301 0.682 rs2929308 chr8:9084121 T/A cg27411982 chr8:10470053 RP1L1 -0.42 -6.6 -0.34 1.64e-10 Joint mobility (Beighton score); LUSC cis rs7655841 0.504 rs10028974 chr4:129871442 C/A cg26347359 chr4:129759716 PHF17 0.53 7.78 0.39 8.91e-14 Chronic obstructive pulmonary disease (moderate to severe); LUSC cis rs6424115 0.830 rs6680132 chr1:24198804 T/C cg10978503 chr1:24200527 CNR2 0.53 13.1 0.58 6.34e-32 Immature fraction of reticulocytes; LUSC cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg08807101 chr21:30365312 RNF160 -0.69 -12.08 -0.55 3.97e-28 Dental caries; LUSC trans rs7980799 0.682 rs10437795 chr12:33635336 C/G cg26384229 chr12:38710491 ALG10B -0.58 -8.59 -0.43 3.29e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg00074818 chr8:8560427 CLDN23 0.59 9.71 0.47 8.72e-20 Obesity-related traits; LUSC trans rs4650994 0.505 rs2811291 chr1:178574217 C/T cg05059571 chr16:84539110 KIAA1609 0.45 8.6 0.43 3.16e-16 HDL cholesterol levels;HDL cholesterol; LUSC cis rs2625529 0.652 rs2957734 chr15:72261385 A/G cg16672083 chr15:72433130 SENP8 0.49 8.07 0.4 1.26e-14 Red blood cell count; LUSC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg18876405 chr7:65276391 NA -0.75 -13.58 -0.6 9.72e-34 Calcium levels; LUSC cis rs7553864 0.614 rs10493796 chr1:87614175 A/G cg17420885 chr1:87600446 LOC339524 0.5 7.05 0.36 1.04e-11 Smoking behavior; LUSC cis rs7580658 0.680 rs2069931 chr2:128185569 C/T cg09760422 chr2:128146352 NA -0.27 -5.86 -0.31 1.09e-8 Protein C levels; LUSC cis rs3916 1.000 rs34708625 chr12:121180019 T/C cg02419362 chr12:121203948 SPPL3 0.38 5.9 0.31 8.85e-9 Urinary metabolites (H-NMR features); LUSC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs7474896 0.559 rs1212108 chr10:38094322 A/C cg25427524 chr10:38739819 LOC399744 -0.45 -5.76 -0.3 1.89e-8 Obesity (extreme); LUSC cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg00071950 chr4:10020882 SLC2A9 0.51 8.48 0.42 7.41e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9403521 1.000 rs9403523 chr6:144004981 T/C cg18240653 chr6:144019428 PHACTR2 -0.48 -5.93 -0.31 7.7e-9 Obesity-related traits; LUSC cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg12011299 chr4:100065546 ADH4 -0.63 -9.89 -0.48 2.07e-20 Alcohol dependence; LUSC cis rs6500602 0.826 rs9925719 chr16:4461861 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 7.17 0.37 4.93e-12 Schizophrenia; LUSC trans rs10432489 0.708 rs4290619 chr2:181766959 G/T cg11196870 chr8:41386826 GINS4 -0.9 -5.99 -0.31 5.46e-9 QT interval; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg00431813 chr7:1051703 C7orf50 -0.37 -5.73 -0.3 2.21e-8 Longevity;Endometriosis; LUSC cis rs983392 0.679 rs7128450 chr11:60031270 G/C cg02771260 chr11:59836817 MS4A3 0.37 6.11 0.32 2.83e-9 Alzheimer's disease (late onset); LUSC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg00750074 chr16:89608354 SPG7 -0.43 -7.42 -0.38 9.66e-13 Multiple myeloma (IgH translocation); LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg20295408 chr7:1910781 MAD1L1 -0.46 -6.38 -0.33 5.75e-10 Bipolar disorder and schizophrenia; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg27588902 chr6:42928151 GNMT 0.29 6.32 0.33 8.54e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg08798685 chr6:27730294 NA -0.69 -6.12 -0.32 2.55e-9 Depression; LUSC cis rs9914988 0.887 rs62066838 chr17:27184533 C/T cg19789473 chr17:27170043 C17orf63 0.31 5.95 0.31 6.6e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4774899 0.837 rs12900038 chr15:57409449 G/T cg21617494 chr15:57618479 NA -0.36 -6.0 -0.31 5.23e-9 Urinary tract infection frequency; LUSC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg11861562 chr11:117069780 TAGLN 0.47 8.6 0.43 3.2e-16 Blood protein levels; LUSC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg23625390 chr15:77176239 SCAPER 0.5 7.73 0.39 1.25e-13 Blood metabolite levels; LUSC cis rs2278426 1.000 rs17699030 chr19:11330942 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 -0.68 -5.86 -0.31 1.13e-8 HDL cholesterol; LUSC cis rs11696845 0.666 rs13042905 chr20:43379454 T/C cg25301532 chr20:43378953 KCNK15 0.37 6.55 0.34 2.12e-10 Obesity-related traits; LUSC cis rs6964587 0.626 rs1011372 chr7:91509867 T/C cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg05555928 chr11:63887634 MACROD1 0.48 9.15 0.45 5.85e-18 Platelet count; LUSC cis rs9788682 0.706 rs924840 chr15:78731808 A/T cg24631222 chr15:78858424 CHRNA5 0.67 8.85 0.44 5.05e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg16325326 chr1:53192061 ZYG11B 0.74 12.93 0.58 2.75e-31 Monocyte count; LUSC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg19774624 chr17:42201019 HDAC5 0.79 11.89 0.55 2.08e-27 Total body bone mineral density; LUSC cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg12386194 chr3:101231763 SENP7 0.55 7.58 0.38 3.5e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg05776053 chr2:74358815 NA 0.45 7.12 0.36 6.54e-12 Gestational age at birth (maternal effect); LUSC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg09359103 chr1:154839909 KCNN3 -0.72 -17.47 -0.69 5.45e-49 Prostate cancer; LUSC cis rs2625529 0.590 rs12904652 chr15:72548765 T/C cg16672083 chr15:72433130 SENP8 -0.46 -7.18 -0.37 4.44e-12 Red blood cell count; LUSC cis rs34638657 0.500 rs1056675 chr16:82181934 T/C cg09439754 chr16:82129088 HSD17B2 -0.35 -6.47 -0.33 3.47e-10 Lung adenocarcinoma; LUSC cis rs6938 0.618 rs12901190 chr15:75231452 T/C cg10253484 chr15:75165896 SCAMP2 -0.46 -6.58 -0.34 1.87e-10 Breast cancer; LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg22907277 chr7:1156413 C7orf50 0.62 9.69 0.47 1.01e-19 Longevity;Endometriosis; LUSC cis rs611744 0.625 rs6469168 chr8:109288399 G/T cg21045802 chr8:109455806 TTC35 0.48 7.55 0.38 4.19e-13 Dupuytren's disease; LUSC cis rs17270561 0.779 rs12209218 chr6:25887776 C/A cg17042849 chr6:26104293 HIST1H4C -0.47 -5.76 -0.3 1.94e-8 Iron status biomarkers; LUSC cis rs62408225 1.000 rs17513415 chr6:90947867 C/T cg06866423 chr6:90926672 BACH2 0.4 5.7 0.3 2.59e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11122272 0.735 rs2790882 chr1:231532783 A/G cg06096015 chr1:231504339 EGLN1 -0.58 -10.38 -0.49 4.56e-22 Hemoglobin concentration; LUSC cis rs4604732 0.631 rs12038880 chr1:247624603 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.43 6.15 0.32 2.21e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs3087591 0.708 rs2854305 chr17:29647003 G/A cg24425628 chr17:29625626 OMG;NF1 0.46 6.85 0.35 3.48e-11 Hip circumference; LUSC cis rs2860975 0.967 rs7902572 chr10:96772717 C/A cg09036531 chr10:96991505 NA -0.42 -5.8 -0.3 1.51e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg10360139 chr7:1886902 MAD1L1 -0.38 -5.67 -0.3 3.17e-8 Bipolar disorder and schizophrenia; LUSC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -5.89 -0.31 9.27e-9 Subjective well-being; LUSC trans rs9951602 0.512 rs9946115 chr18:76654531 A/C cg02800362 chr5:177631904 HNRNPAB 0.88 13.05 0.58 9.85e-32 Obesity-related traits; LUSC cis rs6942756 1.000 rs6949950 chr7:128914818 G/A cg02491457 chr7:128862824 NA -0.5 -7.1 -0.36 7.68e-12 White matter hyperintensity burden; LUSC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg07636037 chr3:49044803 WDR6 1.02 17.89 0.7 1.1e-50 Parkinson's disease; LUSC trans rs2244503 0.945 rs17071864 chr3:64939606 C/T cg08115371 chr11:79115706 ODZ4 -0.45 -6.06 -0.31 3.65e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg00999904 chr2:3704751 ALLC -0.33 -6.2 -0.32 1.67e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7172677 1.000 rs2029519 chr15:75415962 A/G cg14664628 chr15:75095509 CSK -0.45 -5.84 -0.3 1.27e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs3857536 0.740 rs9360191 chr6:66942454 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs9326248 0.581 rs10892048 chr11:116814596 A/G cg01368799 chr11:117014884 PAFAH1B2 0.58 8.94 0.44 2.74e-17 Blood protein levels; LUSC cis rs727505 0.865 rs10253613 chr7:124508929 G/A cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg20283391 chr11:68216788 NA -0.57 -8.1 -0.41 1.04e-14 Total body bone mineral density; LUSC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg10621924 chr7:39171070 POU6F2 0.48 7.58 0.38 3.36e-13 IgG glycosylation; LUSC cis rs7659604 0.540 rs7676867 chr4:122671315 T/C cg19748678 chr4:122722346 EXOSC9 -0.43 -6.37 -0.33 6.36e-10 Type 2 diabetes; LUSC cis rs1691799 0.899 rs1168310 chr12:66726355 A/G cg16791601 chr12:66731901 HELB 0.72 12.25 0.56 9.12e-29 White blood cell count (basophil); LUSC cis rs2239815 0.515 rs5762848 chr22:29236308 A/G cg02153584 chr22:29168773 CCDC117 0.54 6.24 0.32 1.29e-9 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg20887711 chr4:1340912 KIAA1530 0.48 7.78 0.39 9.32e-14 Longevity; LUSC cis rs477692 0.544 rs7904404 chr10:131447612 G/A cg05714579 chr10:131428358 MGMT -0.77 -11.67 -0.54 1.23e-26 Response to temozolomide; LUSC trans rs2727020 0.595 rs10769583 chr11:49483193 G/A cg15704280 chr7:45808275 SEPT13 -1.1 -22.16 -0.77 1.46e-67 Coronary artery disease; LUSC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.8 -0.35 4.82e-11 Total body bone mineral density; LUSC cis rs7215564 0.908 rs8076854 chr17:78663962 A/G cg23238734 chr17:78661607 RPTOR 0.48 6.12 0.32 2.63e-9 Myopia (pathological); LUSC cis rs1577917 0.771 rs7762321 chr6:86412146 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.47 7.66 0.39 2.05e-13 Response to antipsychotic treatment; LUSC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg04111992 chr7:158790115 NA -0.45 -7.25 -0.37 2.94e-12 Facial morphology (factor 20); LUSC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC trans rs9929218 0.559 rs55907909 chr16:68805805 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.96 19.14 0.72 1.15e-55 Colorectal cancer; LUSC trans rs4650994 0.544 rs4132058 chr1:178505557 A/C cg05059571 chr16:84539110 KIAA1609 -0.48 -9.14 -0.45 6.21e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 -0.25 -5.73 -0.3 2.27e-8 Electroencephalogram traits; LUSC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.43 5.77 0.3 1.85e-8 Colonoscopy-negative controls vs population controls; LUSC trans rs7615952 0.800 rs35390120 chr3:125599809 G/A cg07211511 chr3:129823064 LOC729375 -0.99 -12.34 -0.56 4.37e-29 Blood pressure (smoking interaction); LUSC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.08 -0.32 3.35e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3741151 0.773 rs61345051 chr11:73112305 T/C cg17517138 chr11:73019481 ARHGEF17 0.98 8.39 0.42 1.34e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9399135 1.000 rs11754265 chr6:135356216 C/G cg22676075 chr6:135203613 NA 0.48 7.49 0.38 6.19e-13 Red blood cell count; LUSC cis rs8031584 0.678 rs35098644 chr15:31145440 A/G cg14298792 chr15:30685198 CHRFAM7A -0.66 -8.33 -0.41 2.08e-15 Huntington's disease progression; LUSC cis rs68170813 0.562 rs17429825 chr7:107050731 C/T cg02696742 chr7:106810147 HBP1 -0.64 -9.09 -0.45 8.97e-18 Coronary artery disease; LUSC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg04369109 chr6:150039330 LATS1 -0.55 -8.26 -0.41 3.45e-15 Lung cancer; LUSC cis rs208520 0.565 rs1385222 chr6:66753013 C/T cg07460842 chr6:66804631 NA 1.17 22.83 0.78 3.47e-70 Exhaled nitric oxide output; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg10729496 chr3:10149963 C3orf24 0.56 7.5 0.38 5.84e-13 Alzheimer's disease; LUSC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg08088566 chr11:430123 ANO9 0.6 7.04 0.36 1.09e-11 Body mass index; LUSC cis rs1865760 1.000 rs9348698 chr6:25929689 T/A cg17691542 chr6:26056736 HIST1H1C 0.47 7.01 0.36 1.3e-11 Height; LUSC cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.03 -0.4 1.69e-14 Chronic sinus infection; LUSC cis rs6456156 0.792 rs4710181 chr6:167513998 T/C cg07741184 chr6:167504864 NA 0.37 6.46 0.33 3.62e-10 Primary biliary cholangitis; LUSC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg18225595 chr11:63971243 STIP1 0.43 6.99 0.36 1.47e-11 Platelet count; LUSC cis rs11122272 0.735 rs2790883 chr1:231532726 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.05 -0.48 6.23e-21 Hemoglobin concentration; LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg18404041 chr3:52824283 ITIH1 -0.62 -11.96 -0.55 1.13e-27 Bipolar disorder; LUSC cis rs2806561 0.765 rs605367 chr1:23518524 T/C cg19743168 chr1:23544995 NA 0.4 8.04 0.4 1.58e-14 Height; LUSC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg12463550 chr7:65579703 CRCP 0.63 5.77 0.3 1.81e-8 Diabetic kidney disease; LUSC cis rs9875589 0.509 rs1906538 chr3:14014169 C/T cg19554555 chr3:13937349 NA -0.37 -5.69 -0.3 2.82e-8 Ovarian reserve; LUSC cis rs3020736 0.519 rs5996116 chr22:42517492 G/A cg05082376 chr22:42548792 NA 0.43 6.46 0.33 3.79e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg00290607 chr11:67383545 NA 0.37 7.01 0.36 1.3e-11 Mean corpuscular volume; LUSC cis rs7100689 0.646 rs1340375 chr10:82129039 C/T cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs8028313 0.731 rs6494678 chr15:67946247 C/T cg24579218 chr15:68104479 NA -0.38 -6.56 -0.34 2.03e-10 Obesity; LUSC trans rs8040855 0.931 rs11855471 chr15:85719207 T/C cg00988175 chr11:59481031 OR10V1 -0.3 -6.5 -0.34 2.89e-10 Bulimia nervosa; LUSC cis rs4888262 0.526 rs8057279 chr16:74627303 C/T cg01733217 chr16:74700730 RFWD3 0.8 13.43 0.59 3.48e-33 Testicular germ cell tumor; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg21782813 chr7:2030301 MAD1L1 0.49 8.42 0.42 1.12e-15 Bipolar disorder and schizophrenia; LUSC trans rs61931739 0.500 rs7979482 chr12:34542877 C/A cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg01475377 chr6:109611718 NA -0.41 -7.2 -0.37 4.08e-12 Reticulocyte fraction of red cells; LUSC cis rs9534288 0.699 rs1467665 chr13:46662919 C/T cg15192986 chr13:46630673 CPB2 -0.76 -11.24 -0.52 4.42e-25 Blood protein levels; LUSC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg04756594 chr16:24857601 SLC5A11 0.47 6.4 0.33 5.23e-10 Intelligence (multi-trait analysis); LUSC cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 8.06 0.4 1.41e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7618501 0.966 rs13063621 chr3:49821625 T/C cg24110177 chr3:50126178 RBM5 -0.42 -6.6 -0.34 1.63e-10 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.745 rs73192151 chr7:105211876 A/G cg13798780 chr7:105162888 PUS7 0.56 5.83 0.3 1.28e-8 Bipolar disorder (body mass index interaction); LUSC cis rs11122272 0.735 rs2749717 chr1:231489353 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.85 -0.47 2.93e-20 Hemoglobin concentration; LUSC cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg17063962 chr7:91808500 NA -0.59 -9.28 -0.45 2.13e-18 Breast cancer; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg16145915 chr7:1198662 ZFAND2A -0.51 -9.92 -0.48 1.73e-20 Longevity;Endometriosis; LUSC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.56 0.38 4.05e-13 Multiple sclerosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26528255 chr1:27652089 TMEM222 0.57 7.08 0.36 8.66e-12 Bipolar disorder and schizophrenia; LUSC cis rs12908161 1.000 rs34900908 chr15:85257599 G/A cg12863693 chr15:85201151 NMB 0.42 8.76 0.43 1.02e-16 Schizophrenia; LUSC cis rs9398803 0.835 rs1602278 chr6:126838605 A/C cg19875578 chr6:126661172 C6orf173 0.4 5.81 0.3 1.5e-8 Male-pattern baldness; LUSC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg18876405 chr7:65276391 NA -0.53 -8.43 -0.42 1.06e-15 Aortic root size; LUSC trans rs11057841 1.000 rs11057840 chr12:125316055 A/C cg02981208 chr16:1575201 IFT140 0.51 5.94 0.31 7.04e-9 Lipoprotein-associated phospholipase A2 activity and mass; LUSC cis rs478304 0.651 rs4014195 chr11:65506822 C/G cg10604040 chr11:65559109 OVOL1 -0.31 -5.82 -0.3 1.41e-8 Acne (severe); LUSC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.88 -0.35 2.97e-11 Alzheimer's disease (late onset); LUSC cis rs12295403 1.000 rs12295403 chr11:18689653 G/T cg09887367 chr11:18690185 NA -0.34 -6.99 -0.36 1.5e-11 Ovarian reserve; LUSC cis rs12579753 0.872 rs11519752 chr12:82207300 A/G cg07988820 chr12:82153109 PPFIA2 -0.42 -6.05 -0.31 3.81e-9 Resting heart rate; LUSC cis rs10875746 0.855 rs17122620 chr12:48464475 A/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs13394619 0.935 rs6746291 chr2:11728381 T/C cg07314298 chr2:11723111 GREB1 -0.61 -11.17 -0.52 7.95e-25 Endometriosis; LUSC trans rs7618501 0.573 rs2624824 chr3:50088266 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -9.45 -0.46 6.11e-19 Intelligence (multi-trait analysis); LUSC cis rs8141529 0.732 rs5762784 chr22:29171298 C/T cg02153584 chr22:29168773 CCDC117 0.68 11.01 0.52 3e-24 Lymphocyte counts; LUSC cis rs1801251 0.778 rs778338 chr2:233740227 A/G cg25237894 chr2:233734115 C2orf82 -0.35 -6.63 -0.34 1.35e-10 Coronary artery disease; LUSC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg14416726 chr6:151773293 C6orf211;RMND1 0.7 10.18 0.49 2.21e-21 Menarche (age at onset); LUSC cis rs9420 0.925 rs78587207 chr11:57654991 T/G cg23127183 chr11:57508653 C11orf31 -0.53 -7.54 -0.38 4.59e-13 Schizophrenia; LUSC cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg13010199 chr12:38710504 ALG10B 0.63 9.55 0.46 2.97e-19 Bladder cancer; LUSC cis rs6469656 0.892 rs4278180 chr8:117726681 C/T cg24004040 chr8:117650383 NA -0.45 -6.48 -0.33 3.3e-10 Colorectal cancer; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg20273774 chr5:180671298 GNB2L1;SNORD95 0.33 6.24 0.32 1.36e-9 Tuberculosis; LUSC cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.13 -0.41 8.71e-15 Chronic sinus infection; LUSC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg15017067 chr4:17643749 FAM184B 0.35 5.75 0.3 2.02e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.8 8.21 0.41 5.03e-15 Initial pursuit acceleration; LUSC trans rs7829975 0.591 rs12677543 chr8:8644274 G/C cg27411982 chr8:10470053 RP1L1 0.43 6.84 0.35 3.87e-11 Mood instability; LUSC cis rs2742234 0.518 rs1254967 chr10:43690391 G/A cg15436174 chr10:43711423 RASGEF1A 0.44 7.0 0.36 1.4e-11 Hirschsprung disease; LUSC cis rs394563 0.591 rs237035 chr6:149710848 C/T cg07828024 chr6:149772892 ZC3H12D -0.34 -7.29 -0.37 2.22e-12 Dupuytren's disease; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg13047869 chr3:10149882 C3orf24 0.56 7.63 0.39 2.55e-13 Alzheimer's disease; LUSC cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg02012338 chr4:187126139 CYP4V2 0.62 6.3 0.33 9.52e-10 Blood protein levels; LUSC cis rs739401 1.000 rs739401 chr11:3036324 C/T cg08508325 chr11:3079039 CARS 0.42 9.47 0.46 5.09e-19 Longevity; LUSC cis rs1595825 0.679 rs7590697 chr2:198378546 A/G cg00982548 chr2:198649783 BOLL -0.52 -6.16 -0.32 2.13e-9 Ulcerative colitis; LUSC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg14019146 chr3:50243930 SLC38A3 -0.32 -7.01 -0.36 1.35e-11 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg25019033 chr10:957182 NA -0.51 -6.29 -0.33 9.84e-10 Eosinophil percentage of granulocytes; LUSC cis rs12530845 0.561 rs73725182 chr7:135291001 C/T cg23117316 chr7:135346802 PL-5283 -0.57 -8.57 -0.42 3.93e-16 Red blood cell traits; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg08472276 chr7:1133186 C7orf50;GPER -0.37 -6.05 -0.31 3.95e-9 Longevity;Endometriosis; LUSC cis rs1670533 0.932 rs11731289 chr4:1057773 T/G cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs7666738 0.716 rs6814353 chr4:99074202 A/G cg17366294 chr4:99064904 C4orf37 0.55 9.64 0.47 1.46e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.12 0.52 1.17e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg16606324 chr3:10149918 C3orf24 -0.63 -9.42 -0.46 7.44e-19 Alzheimer's disease; LUSC cis rs881375 0.967 rs2416805 chr9:123676482 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.95 0.31 6.75e-9 Rheumatoid arthritis; LUSC cis rs9300255 0.602 rs1790126 chr12:123683563 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.15 -0.32 2.19e-9 Neutrophil percentage of white cells; LUSC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.75 0.35 6.45e-11 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17942371 chr19:796826 PTBP1 0.43 5.97 0.31 6.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7607369 0.714 rs55900247 chr2:219618708 T/C cg02176678 chr2:219576539 TTLL4 -0.7 -13.3 -0.59 1.08e-32 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs62400317 0.859 rs10948223 chr6:45273921 A/C cg18551225 chr6:44695536 NA -0.42 -7.0 -0.36 1.39e-11 Total body bone mineral density; LUSC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg10802521 chr3:52805072 NEK4 -0.54 -8.89 -0.44 3.84e-17 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15722731 chr6:122720674 HSF2 -0.51 -6.07 -0.32 3.38e-9 Bipolar disorder and schizophrenia; LUSC trans rs8072100 0.817 rs12449647 chr17:45548958 C/A cg04995722 chr7:26192034 NFE2L3 -0.43 -6.7 -0.34 8.8e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4073416 0.542 rs7143318 chr14:65940689 G/A cg03016385 chr14:66212404 NA -0.39 -5.83 -0.3 1.3e-8 N-glycan levels; LUSC cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg11657440 chr19:46296263 DMWD -0.54 -7.68 -0.39 1.75e-13 Coronary artery disease; LUSC cis rs4721295 0.546 rs1637766 chr7:2204400 G/A cg14004847 chr7:1930337 MAD1L1 0.44 6.63 0.34 1.32e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg24450063 chr1:156163899 SLC25A44 -1.18 -30.57 -0.86 8.33e-99 Testicular germ cell tumor; LUSC cis rs4629710 0.592 rs1885641 chr6:131553986 A/G cg12700074 chr6:131571435 AKAP7 -0.35 -5.9 -0.31 8.89e-9 Multiple myeloma (IgH translocation); LUSC trans rs9329221 0.662 rs9650650 chr8:10247976 C/T cg06636001 chr8:8085503 FLJ10661 0.54 7.3 0.37 2.15e-12 Neuroticism; LUSC cis rs4664308 0.905 rs62175518 chr2:160915149 C/T cg03641300 chr2:160917029 PLA2R1 -0.63 -10.62 -0.5 6.75e-23 Idiopathic membranous nephropathy; LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg23034840 chr1:205782522 SLC41A1 0.68 9.55 0.46 2.97e-19 Prostate-specific antigen levels; LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs7178375 0.607 rs71474639 chr15:31213257 A/G cg15020726 chr15:31196382 MTMR15 0.84 7.7 0.39 1.59e-13 Hypertriglyceridemia; LUSC cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg07148914 chr20:33460835 GGT7 0.53 7.98 0.4 2.41e-14 Height; LUSC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg13939156 chr17:80058883 NA -0.35 -7.03 -0.36 1.18e-11 Life satisfaction; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg16606324 chr3:10149918 C3orf24 0.68 9.9 0.48 2.05e-20 Alzheimer's disease; LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg25036284 chr2:26402008 FAM59B -0.68 -9.27 -0.45 2.41e-18 Gut microbiome composition (summer); LUSC cis rs7089973 0.872 rs17092497 chr10:116612628 G/A cg23260525 chr10:116636907 FAM160B1 0.4 8.26 0.41 3.54e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs8072100 0.790 rs11656856 chr17:45714671 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 0.38 6.41 0.33 4.88e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg15556689 chr8:8085844 FLJ10661 -0.64 -9.75 -0.47 6.14e-20 Neuroticism; LUSC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.19 -0.37 4.16e-12 Major depressive disorder; LUSC cis rs1577917 0.771 rs7452605 chr6:86240951 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.57 0.42 3.85e-16 Response to antipsychotic treatment; LUSC cis rs12474201 0.928 rs35825831 chr2:46932544 T/G cg06386533 chr2:46925753 SOCS5 0.77 11.6 0.54 2.19e-26 Height; LUSC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg20203395 chr5:56204925 C5orf35 -0.58 -8.14 -0.41 7.93e-15 Initial pursuit acceleration; LUSC cis rs62064224 0.720 rs8078837 chr17:30763537 A/G cg25809561 chr17:30822961 MYO1D 0.57 10.04 0.48 6.7e-21 Schizophrenia; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg06145435 chr7:1022769 CYP2W1 0.29 5.96 0.31 6.51e-9 Longevity;Endometriosis; LUSC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg05313129 chr8:58192883 C8orf71 -0.5 -6.51 -0.34 2.72e-10 Developmental language disorder (linguistic errors); LUSC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg09455208 chr3:40491958 NA 0.52 9.16 0.45 5.22e-18 Renal cell carcinoma; LUSC cis rs6138458 1.000 rs227629 chr20:24913551 G/T cg26195577 chr20:24973756 C20orf3 1.11 18.4 0.71 1.06e-52 Blood protein levels; LUSC cis rs2271400 1.000 rs2271400 chr8:56791244 C/T cg08894788 chr8:56792171 LYN -0.44 -6.97 -0.36 1.74e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Myeloid white cell count;Neutrophil count;Granulocyte count; LUSC cis rs7524258 0.903 rs4908609 chr1:7292910 G/A cg07173049 chr1:7289937 CAMTA1 0.37 7.6 0.38 3.01e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC trans rs2797160 0.967 rs8180614 chr6:126000599 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.59 -0.34 1.71e-10 Endometrial cancer; LUSC cis rs854765 0.618 rs9908017 chr17:17774422 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.77 -13.42 -0.59 3.73e-33 Total body bone mineral density; LUSC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg06212747 chr3:49208901 KLHDC8B 0.45 6.11 0.32 2.77e-9 Parkinson's disease; LUSC cis rs1577917 1.000 rs12664335 chr6:86597774 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.48 6.87 0.35 3.1e-11 Response to antipsychotic treatment; LUSC cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg24642439 chr20:33292090 TP53INP2 0.48 7.1 0.36 7.55e-12 Glomerular filtration rate (creatinine); LUSC cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.41e-9 Crohn's disease; LUSC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg11871910 chr12:69753446 YEATS4 0.63 9.63 0.47 1.52e-19 Blood protein levels; LUSC cis rs548181 0.673 rs12288034 chr11:125570941 A/T cg03464685 chr11:125439445 EI24 -1.09 -12.93 -0.58 2.86e-31 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01176458 chr3:27763828 EOMES 0.46 7.0 0.36 1.4e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.967 rs439017 chr6:145806123 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.79 0.35 5.03e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.35 0.42 1.86e-15 Schizophrenia; LUSC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg05025164 chr4:1340916 KIAA1530 0.42 6.64 0.34 1.29e-10 Longevity; LUSC cis rs35883536 0.967 rs1582091 chr1:101177133 G/T cg06223162 chr1:101003688 GPR88 0.33 5.93 0.31 7.72e-9 Monocyte count; LUSC cis rs796364 0.760 rs74993507 chr2:201068684 C/A cg23649088 chr2:200775458 C2orf69 -0.57 -6.73 -0.35 7.26e-11 Schizophrenia; LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg08677398 chr8:58056175 NA 0.53 6.47 0.33 3.43e-10 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg07167872 chr1:205819463 PM20D1 0.75 13.53 0.59 1.51e-33 Menarche (age at onset); LUSC cis rs9300255 0.739 rs1969354 chr12:123741776 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.43 0.33 4.29e-10 Neutrophil percentage of white cells; LUSC cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -6.88 -0.35 3.04e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs28647808 0.881 rs41316982 chr9:136259117 C/T cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg25428297 chr7:1022841 CYP2W1 0.28 5.98 0.31 5.59e-9 Longevity;Endometriosis; LUSC trans rs3808502 0.525 rs13280813 chr8:11425105 G/T cg11608241 chr8:8085544 FLJ10661 -0.47 -6.7 -0.34 8.86e-11 Neuroticism; LUSC cis rs4808199 0.895 rs10419672 chr19:19471241 T/C cg03709012 chr19:19516395 GATAD2A 1.05 12.98 0.58 1.73e-31 Nonalcoholic fatty liver disease; LUSC cis rs6121246 0.529 rs73235789 chr20:30196148 T/C cg13852791 chr20:30311386 BCL2L1 0.72 8.29 0.41 2.73e-15 Mean corpuscular hemoglobin; LUSC cis rs9788682 1.000 rs2036534 chr15:78826948 T/C cg06917634 chr15:78832804 PSMA4 -0.59 -7.1 -0.36 7.43e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7568458 0.783 rs1561198 chr2:85809989 C/T cg17127132 chr2:85788382 GGCX 0.46 7.35 0.37 1.52e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg09997546 chr11:8931473 C11orf17;ST5 0.39 8.36 0.42 1.75e-15 Hemoglobin concentration; LUSC trans rs11098499 0.619 rs28502463 chr4:120257023 T/C cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.34e-10 Corneal astigmatism; LUSC cis rs10875746 0.903 rs12304476 chr12:48482153 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs7223966 0.921 rs2854207 chr17:61947107 C/G cg11494091 chr17:61959527 GH2 0.37 6.07 0.32 3.47e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2857891 0.695 rs2857896 chr11:6982825 A/T cg14883916 chr11:6947541 ZNF215 0.41 5.71 0.3 2.51e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs981844 1.000 rs56331473 chr4:154668052 C/A cg14289246 chr4:154710475 SFRP2 0.48 6.1 0.32 2.87e-9 Response to statins (LDL cholesterol change); LUSC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.68 -0.39 1.82e-13 Height; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg12188830 chr3:57741926 SLMAP 0.35 6.11 0.32 2.77e-9 Triglycerides; LUSC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg01181863 chr3:195395398 SDHAP2 -0.59 -8.04 -0.4 1.53e-14 Pancreatic cancer; LUSC cis rs6433857 0.536 rs12474658 chr2:181352992 G/T cg23363182 chr2:181467187 NA -0.41 -6.51 -0.34 2.71e-10 Body mass index; LUSC cis rs72781680 0.716 rs17045975 chr2:24099611 A/T cg08917208 chr2:24149416 ATAD2B -0.58 -6.84 -0.35 3.74e-11 Lymphocyte counts; LUSC cis rs7215564 1.000 rs7215564 chr17:78737287 A/G cg23238734 chr17:78661607 RPTOR 0.44 5.71 0.3 2.53e-8 Myopia (pathological); LUSC cis rs7954584 0.626 rs12809676 chr12:122442381 C/A cg01765077 chr12:122356316 WDR66 0.5 6.97 0.36 1.75e-11 Mean corpuscular volume; LUSC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs3812762 0.833 rs35670750 chr11:8782444 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.38 -6.28 -0.32 1.08e-9 Hypospadias; LUSC cis rs354225 0.544 rs12713266 chr2:54805443 G/T cg26097391 chr2:54893211 SPTBN1 0.46 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs2734839 0.964 rs1800498 chr11:113291588 G/A cg14159747 chr11:113255604 NA 0.23 5.75 0.3 1.98e-8 Information processing speed; LUSC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg05855489 chr10:104503620 C10orf26 0.51 7.26 0.37 2.67e-12 Arsenic metabolism; LUSC cis rs4964805 0.913 rs11111793 chr12:104198118 G/T cg02344784 chr12:104178138 NT5DC3 0.4 6.34 0.33 7.52e-10 Attention deficit hyperactivity disorder; LUSC cis rs6815814 0.950 rs11722788 chr4:38810738 C/G cg02016764 chr4:38805732 TLR1 -0.55 -5.99 -0.31 5.38e-9 Breast cancer; LUSC trans rs2797160 1.000 rs1739377 chr6:126012236 T/C cg05039488 chr6:79577232 IRAK1BP1 0.44 6.58 0.34 1.83e-10 Endometrial cancer; LUSC cis rs1957429 0.731 rs1951495 chr14:65336690 T/C cg23373153 chr14:65346875 NA 0.94 10.29 0.49 9.2e-22 Pediatric areal bone mineral density (radius); LUSC trans rs7181230 0.885 rs28444847 chr15:40356604 C/T cg22705835 chr10:65332833 REEP3 -0.4 -6.43 -0.33 4.46e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg12516959 chr21:47718080 NA -0.38 -6.15 -0.32 2.25e-9 Testicular germ cell tumor; LUSC cis rs7103648 0.643 rs12365079 chr11:47696596 A/T cg20307385 chr11:47447363 PSMC3 0.81 12.57 0.57 5.97e-30 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs7315438 0.599 rs7955092 chr12:115875881 T/C cg24172291 chr12:115889509 NA -0.35 -5.96 -0.31 6.27e-9 Colorectal cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24082730 chr3:126076366 KLF15 -0.41 -6.26 -0.32 1.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg16928487 chr17:17741425 SREBF1 0.33 6.07 0.32 3.55e-9 Total body bone mineral density; LUSC cis rs7312933 0.558 rs1796384 chr12:42780568 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.88 -0.35 3e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9612 1.000 rs1058 chr19:44268325 C/G cg08581076 chr19:44259116 C19orf61 0.49 5.96 0.31 6.39e-9 Exhaled nitric oxide output; LUSC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.07 -0.32 3.41e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg10224037 chr5:178157518 ZNF354A 0.8 12.3 0.56 6.38e-29 Neutrophil percentage of white cells; LUSC cis rs6429082 0.749 rs291362 chr1:235686690 T/A cg26050004 chr1:235667680 B3GALNT2 0.66 9.44 0.46 6.8e-19 Adiposity; LUSC cis rs17407555 0.647 rs55811736 chr4:10014221 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -6.24 -0.32 1.3e-9 Schizophrenia (age at onset); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg08020177 chr16:19535130 CP110 0.51 6.19 0.32 1.76e-9 Cognitive function;Information processing speed; LUSC cis rs2688608 0.967 rs1815076 chr10:75659886 C/T cg17411546 chr10:75410026 SYNPO2L -0.43 -6.3 -0.33 9.58e-10 Inflammatory bowel disease; LUSC cis rs13401104 0.796 rs57900956 chr2:237119214 C/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs6546550 0.867 rs726920 chr2:70152027 G/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.4 -0.38 1.09e-12 Prevalent atrial fibrillation; LUSC cis rs7799006 0.606 rs878534 chr7:2314652 G/A cg08027265 chr7:2291960 NA -0.62 -11.08 -0.52 1.61e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4499344 0.730 rs259279 chr19:33161274 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.95 -16.03 -0.66 2.68e-43 Mean platelet volume; LUSC cis rs950776 0.518 rs62008174 chr15:78808947 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.41 0.33 4.82e-10 Sudden cardiac arrest; LUSC cis rs66887589 0.870 rs2389875 chr4:120557014 G/T cg24375607 chr4:120327624 NA -0.46 -6.91 -0.35 2.46e-11 Diastolic blood pressure; LUSC trans rs13011075 0.919 rs62143899 chr2:68604553 C/T cg14221825 chr19:46271408 SIX5 0.43 6.19 0.32 1.75e-9 Mean corpuscular volume; LUSC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg18876405 chr7:65276391 NA 0.68 12.02 0.55 6.86e-28 Aortic root size; LUSC cis rs7927771 0.524 rs12785949 chr11:47729770 C/T cg20307385 chr11:47447363 PSMC3 0.44 6.41 0.33 4.83e-10 Subjective well-being; LUSC cis rs11779988 0.545 rs411531 chr8:17795934 A/G cg01800426 chr8:17659068 MTUS1 -0.49 -5.93 -0.31 7.44e-9 Breast cancer; LUSC cis rs68170813 0.559 rs77422419 chr7:106957932 A/G cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC cis rs2884670 1.000 rs2884670 chr12:4675218 C/T cg11146114 chr12:4671731 NA -0.38 -6.11 -0.32 2.72e-9 Allergic rhinitis; LUSC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs11122272 0.701 rs11122273 chr1:231476789 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.29 -0.41 2.8e-15 Hemoglobin concentration; LUSC cis rs2295359 0.892 rs17375018 chr1:67655147 A/G cg12940439 chr1:67600707 NA -0.35 -5.83 -0.3 1.3e-8 Psoriasis; LUSC cis rs2871473 0.951 rs1030025 chr2:103105611 A/T cg09003973 chr2:102972529 NA 0.64 7.34 0.37 1.65e-12 Blood protein levels; LUSC cis rs1595825 0.891 rs73061069 chr2:198908825 A/G cg10547527 chr2:198650123 BOLL -0.51 -6.09 -0.32 3.14e-9 Ulcerative colitis; LUSC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.28 -0.33 1.03e-9 Developmental language disorder (linguistic errors); LUSC cis rs17102423 0.559 rs7160037 chr14:65490948 T/C cg11161011 chr14:65562177 MAX -0.73 -10.06 -0.48 5.59e-21 Obesity-related traits; LUSC cis rs79387448 0.745 rs7572284 chr2:103119423 C/A cg09003973 chr2:102972529 NA 0.86 8.6 0.43 3.07e-16 Gut microbiota (bacterial taxa); LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs11711311 0.911 rs28577577 chr3:113447276 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.14 0.36 5.87e-12 IgG glycosylation; LUSC cis rs6060717 0.702 rs6060756 chr20:34608479 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.44 6.36 0.33 6.61e-10 Hip circumference adjusted for BMI; LUSC cis rs11971779 0.715 rs7781459 chr7:139093882 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs10191773 0.584 rs72831633 chr2:112945932 T/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.74 7.72 0.39 1.39e-13 Yeast infection; LUSC cis rs34779708 0.898 rs11595898 chr10:35326263 T/C cg04310649 chr10:35416472 CREM -0.4 -6.04 -0.31 4.2e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2797160 1.000 rs2797161 chr6:126010789 A/G cg05901451 chr6:126070800 HEY2 0.56 8.46 0.42 8.35e-16 Endometrial cancer; LUSC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg11632617 chr15:75315747 PPCDC -0.48 -6.38 -0.33 6.02e-10 Blood trace element (Zn levels); LUSC cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs10197940 0.662 rs2432945 chr2:152278414 T/C cg19508488 chr2:152266495 RIF1 0.45 6.51 0.34 2.81e-10 Lung cancer; LUSC trans rs11098499 0.821 rs10032151 chr4:120391628 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.22e-9 Corneal astigmatism; LUSC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.65 0.39 2.21e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg22963979 chr7:1858916 MAD1L1 -0.5 -7.36 -0.37 1.45e-12 Schizophrenia; LUSC cis rs7577851 1.000 rs72837952 chr2:69742989 C/A cg10773587 chr2:69614142 GFPT1 0.49 5.67 0.3 3.04e-8 Parkinson's disease (age of onset); LUSC cis rs11758351 0.929 rs75475698 chr6:26190609 C/G cg11342453 chr6:26196699 NA 0.54 5.71 0.3 2.52e-8 Gout;Renal underexcretion gout; LUSC trans rs2262909 0.719 rs12461632 chr19:22245089 G/A cg17074339 chr11:11642133 GALNTL4 0.47 7.14 0.36 5.86e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg06640241 chr16:89574553 SPG7 0.87 16.22 0.66 4.75e-44 Multiple myeloma (IgH translocation); LUSC cis rs7539409 0.915 rs1977119 chr1:84275509 A/G cg10977910 chr1:84465055 TTLL7 0.64 6.05 0.31 3.84e-9 Alzheimer's disease; LUSC trans rs2197308 0.565 rs4123923 chr12:37857684 T/C cg06521331 chr12:34319734 NA -0.4 -6.1 -0.32 2.95e-9 Morning vs. evening chronotype; LUSC trans rs11098499 0.954 rs7654587 chr4:120388406 C/T cg25214090 chr10:38739885 LOC399744 0.58 8.48 0.42 7.42e-16 Corneal astigmatism; LUSC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg05084668 chr3:125655381 ALG1L -0.48 -6.86 -0.35 3.28e-11 Blood pressure (smoking interaction); LUSC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.55 -8.17 -0.41 6.38e-15 Axial length; LUSC cis rs62400317 0.762 rs62436374 chr6:44874785 C/G cg18551225 chr6:44695536 NA -0.46 -7.44 -0.38 8.7e-13 Total body bone mineral density; LUSC cis rs7020830 0.931 rs9775431 chr9:37130433 G/A cg14294708 chr9:37120828 ZCCHC7 1.05 23.86 0.79 3.67e-74 Schizophrenia; LUSC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg05802129 chr4:122689817 NA -0.5 -8.12 -0.41 9.17e-15 Type 2 diabetes; LUSC cis rs7568458 0.636 rs11126995 chr2:85792408 A/T cg23752985 chr2:85803571 VAMP8 0.34 6.67 0.34 1.05e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7246657 0.943 rs8109038 chr19:38015709 A/G cg23950597 chr19:37808831 NA 0.61 7.24 0.37 3.18e-12 Coronary artery calcification; LUSC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg06640241 chr16:89574553 SPG7 0.88 15.83 0.65 1.64e-42 Multiple myeloma (IgH translocation); LUSC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg02574844 chr11:5959923 NA -0.43 -6.55 -0.34 2.15e-10 DNA methylation (variation); LUSC cis rs7824557 0.505 rs2736313 chr8:11086942 C/T cg27411982 chr8:10470053 RP1L1 0.37 5.79 0.3 1.59e-8 Retinal vascular caliber; LUSC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg22815214 chr1:201083145 CACNA1S 0.6 10.41 0.49 3.67e-22 Permanent tooth development; LUSC cis rs6088580 0.524 rs7269596 chr20:33229063 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -8.06 -0.4 1.39e-14 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg08280861 chr8:58055591 NA 0.57 6.2 0.32 1.67e-9 Developmental language disorder (linguistic errors); LUSC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg04450456 chr4:17643702 FAM184B 0.38 6.45 0.33 3.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs9976767 0.686 rs11203203 chr21:43836186 A/G cg19517470 chr6:98488842 NA -0.28 -6.02 -0.31 4.62e-9 Type 1 diabetes; LUSC cis rs73198271 0.603 rs546606 chr8:8595843 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -5.74 -0.3 2.18e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4911253 0.509 rs66499347 chr20:31448696 C/T cg13636640 chr20:31349939 DNMT3B -0.81 -14.37 -0.62 8.49e-37 Lymphocyte counts; LUSC cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.45 0.53 7.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg00546932 chr16:1947055 NA 0.37 5.68 0.3 2.97e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs10144321 0.810 rs2273800 chr14:100847707 C/T cg14882082 chr14:100845427 WDR25 -0.42 -8.21 -0.41 4.73e-15 Menarche (age at onset); LUSC trans rs853679 0.517 rs9468286 chr6:28079428 C/T cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs8060686 0.641 rs12599880 chr16:68152035 A/G cg27539214 chr16:67997921 SLC12A4 -0.57 -7.4 -0.38 1.12e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs11828289 0.660 rs17306426 chr11:23222079 G/T cg20040320 chr11:23191996 NA 0.59 6.28 0.33 1.05e-9 Cancer; LUSC cis rs113835537 0.529 rs7943327 chr11:66256581 G/C cg24851651 chr11:66362959 CCS 0.54 8.15 0.41 7.38e-15 Airway imaging phenotypes; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg18765479 chr12:132426275 PUS1 -0.38 -6.01 -0.31 4.94e-9 N-glycan levels; LUSC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg26513180 chr16:89883248 FANCA 0.64 10.21 0.49 1.72e-21 Vitiligo; LUSC cis rs7851660 0.809 rs10739526 chr9:100662671 T/C cg13688889 chr9:100608707 NA -0.54 -8.43 -0.42 1.05e-15 Strep throat; LUSC cis rs926938 0.608 rs360612 chr1:115394747 G/A cg12756093 chr1:115239321 AMPD1 0.53 8.12 0.41 9.04e-15 Autism; LUSC cis rs12824058 0.737 rs2398508 chr12:130816460 G/A cg24838063 chr12:130822603 PIWIL1 0.7 10.3 0.49 8.96e-22 Menopause (age at onset); LUSC cis rs12541635 0.639 rs1032545 chr8:107005825 C/T cg10147462 chr8:107024639 NA 0.68 14.29 0.62 1.73e-36 Age of smoking initiation; LUSC cis rs7503807 0.967 rs12940622 chr17:78615571 G/A cg09596252 chr17:78655493 RPTOR 0.44 7.43 0.38 9.4e-13 Obesity; LUSC cis rs2688608 0.901 rs2664282 chr10:75620757 T/C cg17411546 chr10:75410026 SYNPO2L -0.42 -5.97 -0.31 6.03e-9 Inflammatory bowel disease; LUSC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs637571 0.510 rs12575663 chr11:65574535 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.39 -6.91 -0.35 2.42e-11 Eosinophil percentage of white cells; LUSC cis rs9329289 0.603 rs2458705 chr10:2541377 A/G cg05625103 chr10:2543513 NA 0.42 6.38 0.33 6.06e-10 Age-related hearing impairment; LUSC cis rs9473147 0.543 rs7738044 chr6:47469273 A/G cg20196966 chr6:47445060 CD2AP 0.42 5.83 0.3 1.31e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs12291225 0.679 rs11023178 chr11:14310282 G/A cg19336497 chr11:14380999 RRAS2 -0.57 -11.56 -0.53 3.17e-26 Sense of smell; LUSC trans rs2392780 0.536 rs2691039 chr8:128334662 A/G cg10195415 chr17:73887371 TRIM65 0.41 6.51 0.34 2.68e-10 Breast cancer (early onset); LUSC cis rs559928 0.606 rs17773078 chr11:63906224 G/A cg24687543 chr11:63912206 MACROD1 0.47 5.96 0.31 6.34e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs208515 0.525 rs12191500 chr6:66668681 A/G cg07460842 chr6:66804631 NA 1.04 14.11 0.61 9.12e-36 Exhaled nitric oxide levels; LUSC cis rs4268898 0.932 rs7577964 chr2:24598279 A/G cg06627628 chr2:24431161 ITSN2 0.6 8.76 0.43 1.03e-16 Asthma; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg22963979 chr7:1858916 MAD1L1 -0.74 -12.54 -0.57 7.99e-30 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 8.12e-16 Aortic root size; LUSC cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg00677455 chr12:58241039 CTDSP2 0.57 7.62 0.38 2.6e-13 Multiple sclerosis; LUSC cis rs11671005 0.693 rs11668821 chr19:58955813 G/A cg13877915 chr19:58951672 ZNF132 0.45 5.78 0.3 1.71e-8 Mean platelet volume; LUSC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg23711669 chr6:146136114 FBXO30 0.76 12.35 0.56 4.01e-29 Lobe attachment (rater-scored or self-reported); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10132348 chr4:6784379 KIAA0232 -0.5 -6.45 -0.33 3.91e-10 Bipolar disorder and schizophrenia; LUSC cis rs394563 0.589 rs1900300 chr6:149641627 T/C cg11245181 chr6:149772854 ZC3H12D 0.29 6.29 0.33 9.75e-10 Dupuytren's disease; LUSC cis rs1577917 0.771 rs2484355 chr6:86394403 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.68 -11.0 -0.52 3.09e-24 Response to antipsychotic treatment; LUSC cis rs1152591 0.505 rs1152593 chr14:64675895 C/T cg21174375 chr14:64681225 SYNE2 0.33 5.74 0.3 2.11e-8 Atrial fibrillation; LUSC cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg03233332 chr7:66118400 NA -0.43 -6.17 -0.32 1.92e-9 Aortic root size; LUSC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg01097406 chr16:89675127 NA -0.34 -6.64 -0.34 1.27e-10 Vitiligo; LUSC trans rs11992162 0.550 rs61426048 chr8:11784956 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -6.02 -0.31 4.47e-9 Monocyte count; LUSC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg22431228 chr1:16359049 CLCNKA -0.52 -10.41 -0.5 3.54e-22 Dilated cardiomyopathy; LUSC cis rs4423214 0.959 rs12794668 chr11:71168715 C/T cg05163923 chr11:71159392 DHCR7 0.74 10.98 0.52 3.66e-24 Vitamin D levels; LUSC cis rs12950390 0.853 rs12450729 chr17:45855363 A/G cg06532163 chr17:45867833 NA 0.34 6.41 0.33 4.93e-10 IgG glycosylation; LUSC cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg11102782 chr19:18549136 ISYNA1 -0.34 -6.37 -0.33 6.44e-10 Breast cancer; LUSC cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.91 -0.35 2.49e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2486288 0.656 rs7166580 chr15:45571209 C/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.7 -0.39 1.6e-13 Glomerular filtration rate; LUSC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg25554036 chr4:6271136 WFS1 -0.58 -12.04 -0.55 5.54e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg08807101 chr21:30365312 RNF160 0.8 15.45 0.65 5.01e-41 Dental caries; LUSC cis rs73206853 0.563 rs74869743 chr12:111204031 T/C cg12870014 chr12:110450643 ANKRD13A 0.65 6.91 0.35 2.49e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.26 0.52 3.83e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4631830 0.869 rs4131357 chr10:51537292 C/A cg20129853 chr10:51489980 NA -0.34 -6.77 -0.35 5.84e-11 Prostate-specific antigen levels; LUSC cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs7659604 0.502 rs13108419 chr4:122687238 A/G cg19748678 chr4:122722346 EXOSC9 -0.44 -6.39 -0.33 5.73e-10 Type 2 diabetes; LUSC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.65 9.87 0.48 2.53e-20 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20676401 chr10:5726466 C10orf18 -0.4 -6.02 -0.31 4.5e-9 Electrocardiographic conduction measures; LUSC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg09365446 chr1:150670422 GOLPH3L 0.53 8.02 0.4 1.75e-14 Tonsillectomy; LUSC cis rs62432291 0.681 rs420137 chr6:159652931 G/C cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.28 0.32 1.08e-9 Menarche (age at onset); LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg22868518 chr11:507468 RNH1 -0.64 -5.85 -0.3 1.19e-8 Body mass index; LUSC cis rs7236492 0.688 rs9709477 chr18:77202786 C/A cg15644404 chr18:77186268 NFATC1 -0.67 -7.59 -0.38 3.25e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs137699 1.000 rs2049986 chr22:39756854 C/G cg11247378 chr22:39784982 NA 0.42 7.45 0.38 8.29e-13 IgG glycosylation; LUSC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg15664640 chr17:80829946 TBCD -0.51 -8.89 -0.44 3.99e-17 Breast cancer; LUSC cis rs7577696 0.554 rs34835885 chr2:32325414 G/A cg02381751 chr2:32503542 YIPF4 -0.52 -6.66 -0.34 1.14e-10 Inflammatory biomarkers; LUSC cis rs4132509 0.649 rs12038981 chr1:243866855 G/A cg21452805 chr1:244014465 NA 0.65 6.91 0.35 2.45e-11 RR interval (heart rate); LUSC cis rs12618769 0.597 rs11901568 chr2:99128621 C/T cg10123293 chr2:99228465 UNC50 -0.46 -7.6 -0.38 2.97e-13 Bipolar disorder; LUSC cis rs60695258 0.572 rs375795 chr4:87972465 C/T cg10685359 chr4:87814065 C4orf36 -0.35 -6.24 -0.32 1.3e-9 Hematocrit; LUSC cis rs4654899 0.643 rs651538 chr1:21097866 A/G cg01072550 chr1:21505969 NA -0.45 -6.75 -0.35 6.58e-11 Superior frontal gyrus grey matter volume; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg03461704 chr1:205818484 PM20D1 0.38 6.29 0.33 9.72e-10 Menarche (age at onset); LUSC cis rs17621444 0.522 rs1117218 chr10:121817723 G/A cg02041677 chr10:121771263 NA -0.34 -6.39 -0.33 5.72e-10 IgG glycosylation; LUSC cis rs2230307 0.536 rs560659 chr1:100523536 A/G cg24955406 chr1:100503596 HIAT1 -0.55 -5.88 -0.31 9.8e-9 Carotid intima media thickness; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.61 -10.03 -0.48 7.11e-21 Lymphocyte counts; LUSC cis rs2762353 0.935 rs2817188 chr6:25807603 A/G cg03264133 chr6:25882463 NA -0.42 -7.25 -0.37 2.86e-12 Blood metabolite levels; LUSC cis rs6733011 0.538 rs10175560 chr2:99465418 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.46 -6.17 -0.32 2.01e-9 Bipolar disorder; LUSC cis rs4629180 0.586 rs2048252 chr2:102138384 C/T cg01388757 chr2:102091195 RFX8 -0.35 -6.05 -0.31 3.82e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7605827 0.551 rs4668897 chr2:15480441 C/G cg19274914 chr2:15703543 NA 0.41 7.46 0.38 7.4e-13 Educational attainment (years of education); LUSC cis rs9837602 1.000 rs1038294 chr3:99503728 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.37 -6.02 -0.31 4.66e-9 Breast cancer; LUSC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg12463550 chr7:65579703 CRCP 0.45 6.56 0.34 2.05e-10 Aortic root size; LUSC cis rs11608355 0.705 rs4766601 chr12:109890080 C/G cg05360138 chr12:110035743 NA 0.54 7.06 0.36 9.55e-12 Neuroticism; LUSC trans rs10506458 0.834 rs73125186 chr12:63373400 C/T cg22491629 chr6:157744540 C6orf35 -0.87 -10.69 -0.5 3.83e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs926392 0.896 rs4812357 chr20:37683071 C/T cg27552599 chr20:37590471 DHX35 -0.33 -5.69 -0.3 2.73e-8 Dialysis-related mortality; LUSC cis rs1950500 0.509 rs12882558 chr14:24819233 G/A cg16194253 chr14:24768981 DHRS1;C14orf21 0.55 8.88 0.44 4.09e-17 Height; LUSC cis rs2742234 0.955 rs2435384 chr10:43673731 G/T cg15436174 chr10:43711423 RASGEF1A -0.36 -6.34 -0.33 7.61e-10 Hirschsprung disease; LUSC trans rs7572263 0.528 rs13387151 chr2:209074635 A/C cg15570148 chr3:61235985 FHIT -0.48 -6.02 -0.31 4.52e-9 Glioma;Non-glioblastoma glioma; LUSC cis rs908922 0.676 rs1337338 chr1:152511885 G/A cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC trans rs2392780 0.536 rs594154 chr8:128334911 G/A cg10195415 chr17:73887371 TRIM65 0.41 6.49 0.33 3.12e-10 Breast cancer (early onset); LUSC cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg04267008 chr7:1944627 MAD1L1 -0.49 -7.31 -0.37 1.97e-12 Bipolar disorder and schizophrenia; LUSC cis rs1178968 0.901 rs6949855 chr7:72728130 A/G cg25889504 chr7:72793014 NA 0.58 7.53 0.38 4.84e-13 Triglyceride levels; LUSC trans rs853679 0.607 rs13207345 chr6:28265572 C/T cg06606381 chr12:133084897 FBRSL1 -0.99 -9.43 -0.46 7.11e-19 Depression; LUSC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.88 -0.35 3.05e-11 Total body bone mineral density; LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.78 -0.39 9.25e-14 Bipolar disorder; LUSC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg01475377 chr6:109611718 NA -0.38 -6.75 -0.35 6.74e-11 Reticulocyte fraction of red cells; LUSC cis rs10193935 0.792 rs13430031 chr2:42499968 C/T cg27598129 chr2:42591480 NA -0.59 -8.04 -0.4 1.59e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11190604 1.000 rs3750629 chr10:102275727 A/G cg23241863 chr10:102295624 HIF1AN 0.48 5.9 0.31 9.03e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg26335602 chr6:28129616 ZNF389 0.49 6.56 0.34 2e-10 Parkinson's disease; LUSC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg04362960 chr10:104952993 NT5C2 0.58 8.45 0.42 9e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg23649088 chr2:200775458 C2orf69 -0.55 -6.98 -0.36 1.64e-11 Schizophrenia; LUSC cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg26647111 chr11:31128758 NA -0.41 -5.89 -0.31 9.29e-9 Red blood cell count; LUSC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.94 0.48 1.47e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs17095355 1.000 rs11194926 chr10:111700922 A/G cg00817464 chr10:111662876 XPNPEP1 0.61 7.48 0.38 6.76e-13 Biliary atresia; LUSC cis rs8017423 0.935 rs7158410 chr14:90704370 T/C cg14092571 chr14:90743983 NA -0.36 -5.98 -0.31 5.76e-9 Mortality in heart failure; LUSC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12410462 0.681 rs79461024 chr1:227568783 G/T cg04117972 chr1:227635322 NA 0.61 6.54 0.34 2.3e-10 Major depressive disorder; LUSC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg22920501 chr2:26401640 FAM59B -0.72 -10.51 -0.5 1.69e-22 Gut microbiome composition (summer); LUSC cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -12.16 -0.55 1.99e-28 Chronic sinus infection; LUSC cis rs3106136 0.527 rs4235050 chr4:95157156 A/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.41 -0.42 1.2e-15 Capecitabine sensitivity; LUSC cis rs11758351 0.587 rs2050950 chr6:26234883 A/G cg23601095 chr6:26197514 HIST1H3D 0.69 7.46 0.38 7.54e-13 Gout;Renal underexcretion gout; LUSC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg03709012 chr19:19516395 GATAD2A -0.77 -12.16 -0.55 2.12e-28 Tonsillectomy; LUSC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.39 -7.81 -0.39 7.63e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11644478 chr21:40555479 PSMG1 0.93 18.13 0.7 1.26e-51 Cognitive function; LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg11645453 chr3:52864694 ITIH4 0.34 7.9 0.4 4.07e-14 Bipolar disorder; LUSC trans rs7647973 0.710 rs9869120 chr3:49624065 T/C cg21659725 chr3:3221576 CRBN -0.71 -7.8 -0.39 7.78e-14 Menarche (age at onset); LUSC cis rs7582720 1.000 rs7582720 chr2:203753072 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg02951883 chr7:2050386 MAD1L1 -0.57 -10.31 -0.49 8.07e-22 Schizophrenia; LUSC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.49 -6.21 -0.32 1.55e-9 Schizophrenia; LUSC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg13902645 chr11:5959945 NA -0.55 -7.96 -0.4 2.74e-14 DNA methylation (variation); LUSC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg25072359 chr17:41440525 NA 0.62 9.05 0.44 1.2e-17 Menopause (age at onset); LUSC cis rs9341835 0.772 rs9449233 chr6:64138234 G/T cg03326410 chr6:64151739 NA -0.38 -6.26 -0.32 1.15e-9 Schizophrenia; LUSC cis rs847577 0.609 rs17435590 chr7:97784061 T/C cg24562669 chr7:97807699 LMTK2 0.48 8.76 0.43 1.01e-16 Breast cancer; LUSC cis rs854765 0.624 rs9902941 chr17:17733760 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.71 -12.0 -0.55 8.2e-28 Total body bone mineral density; LUSC cis rs9831754 0.906 rs2102601 chr3:78410536 G/A cg06138941 chr3:78371609 NA -0.65 -9.4 -0.46 8.73e-19 Calcium levels; LUSC cis rs9788721 0.967 rs72740955 chr15:78849779 C/T cg06917634 chr15:78832804 PSMA4 -0.47 -6.31 -0.33 9.05e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg07636037 chr3:49044803 WDR6 0.44 6.37 0.33 6.4e-10 Resting heart rate; LUSC cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.98 0.55 9.29e-28 Chronic sinus infection; LUSC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg05872129 chr22:39784769 NA -0.58 -9.97 -0.48 1.18e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC trans rs7937682 0.663 rs35581942 chr11:111756286 C/T cg18187862 chr3:45730750 SACM1L -0.53 -6.45 -0.33 3.92e-10 Primary sclerosing cholangitis; LUSC trans rs11935423 0.778 rs11943031 chr4:100489204 G/A cg02164153 chr5:172068145 NEURL1B -0.47 -6.01 -0.31 4.77e-9 Gut microbiome composition (summer); LUSC cis rs6674970 1.000 rs6656450 chr1:151089602 A/T cg11822372 chr1:151115635 SEMA6C 0.53 8.11 0.41 9.8e-15 Childhood ear infection; LUSC cis rs981844 0.712 rs6535957 chr4:154749862 C/A cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC cis rs734999 0.545 rs9970196 chr1:2574078 T/C cg18932078 chr1:2524107 MMEL1 -0.3 -6.44 -0.33 4.23e-10 Ulcerative colitis; LUSC cis rs1728785 0.901 rs1728787 chr16:68593042 G/C cg02972257 chr16:68554789 NA -0.52 -6.62 -0.34 1.45e-10 Ulcerative colitis; LUSC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg27165867 chr14:105738592 BRF1 -0.56 -8.49 -0.42 6.9e-16 Mean platelet volume;Platelet distribution width; LUSC trans rs7824557 0.767 rs10104728 chr8:11171300 A/G cg08975724 chr8:8085496 FLJ10661 0.48 7.08 0.36 8.4e-12 Retinal vascular caliber; LUSC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg21770322 chr7:97807741 LMTK2 -0.41 -7.15 -0.36 5.52e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs17661538 0.542 rs71497233 chr10:18423082 G/A cg03634479 chr10:18430412 CACNB2 0.59 5.78 0.3 1.7e-8 Response to antipsychotic treatment; LUSC cis rs7927771 0.524 rs11039431 chr11:47872012 G/T cg20307385 chr11:47447363 PSMC3 0.46 6.77 0.35 5.93e-11 Subjective well-being; LUSC cis rs10905065 0.965 rs7100576 chr10:5784649 G/A cg11519256 chr10:5708881 ASB13 0.4 5.83 0.3 1.33e-8 Menopause (age at onset); LUSC cis rs13031619 1.000 rs6724730 chr2:3697987 G/C cg00999904 chr2:3704751 ALLC 0.45 7.48 0.38 6.49e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2806561 0.894 rs628106 chr1:23537685 C/T cg19743168 chr1:23544995 NA 0.47 10.23 0.49 1.53e-21 Height; LUSC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg26769984 chr7:1090371 C7orf50 0.57 7.85 0.39 5.89e-14 Bronchopulmonary dysplasia; LUSC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs3820068 0.608 rs7514858 chr1:16035246 G/A cg13390004 chr1:15929781 NA 0.42 6.82 0.35 4.38e-11 Systolic blood pressure; LUSC cis rs778371 0.723 rs1078323 chr2:233681512 T/G cg08000102 chr2:233561755 GIGYF2 -0.77 -12.53 -0.57 8.92e-30 Schizophrenia; LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg04267008 chr7:1944627 MAD1L1 0.59 8.92 0.44 3.07e-17 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.09 0.48 4.41e-21 Bladder cancer; LUSC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg00409905 chr10:38381863 ZNF37A -0.38 -6.38 -0.33 5.89e-10 Extrinsic epigenetic age acceleration; LUSC cis rs834603 0.541 rs1704965 chr7:47470215 C/T cg09696706 chr7:47479511 TNS3 0.32 5.75 0.3 2.01e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs1595825 0.891 rs77706948 chr2:198608441 T/G cg00982548 chr2:198649783 BOLL -0.58 -7.15 -0.36 5.37e-12 Ulcerative colitis; LUSC cis rs3540 0.597 rs12708583 chr15:91050271 C/T cg04176472 chr15:90893244 GABARAPL3 0.33 5.91 0.31 8.26e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs751728 0.664 rs943475 chr6:33749978 C/T cg25922239 chr6:33757077 LEMD2 -0.41 -6.25 -0.32 1.25e-9 Crohn's disease; LUSC cis rs7582720 1.000 rs72926783 chr2:203815740 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1550582 1.000 rs7822348 chr8:135542483 C/G cg17885191 chr8:135476712 NA 0.67 9.65 0.47 1.39e-19 Educational attainment; LUSC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg22800045 chr5:56110881 MAP3K1 0.58 7.97 0.4 2.48e-14 Coronary artery disease; LUSC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg21951975 chr1:209979733 IRF6 0.55 6.88 0.35 2.95e-11 Cleft lip with or without cleft palate; LUSC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg26380479 chr7:97908229 NA -0.27 -6.08 -0.32 3.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4077515 0.901 rs11791262 chr9:139271919 C/T cg14019695 chr9:139328340 INPP5E 0.44 8.29 0.41 2.87e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs17401966 0.522 rs12133617 chr1:10288463 C/T cg17425144 chr1:10567563 PEX14 -0.34 -6.05 -0.31 3.83e-9 Hepatocellular carcinoma; LUSC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg17724175 chr1:150552817 MCL1 -0.47 -8.36 -0.42 1.76e-15 Blood protein levels; LUSC trans rs2587949 0.593 rs2587931 chr3:4237523 T/C cg15139668 chr4:4577005 NA -0.4 -6.17 -0.32 1.96e-9 Periodontitis (DPAL); LUSC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg21433313 chr16:3507492 NAT15 -0.78 -9.37 -0.46 1.09e-18 Tuberculosis; LUSC cis rs11250464 0.794 rs11250487 chr10:1434168 C/A cg26394196 chr10:1453818 ADARB2 -0.37 -6.31 -0.33 8.76e-10 Radiation response; LUSC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.43 5.78 0.3 1.71e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs308403 0.533 rs309377 chr4:123676353 G/A cg10495464 chr4:123653540 BBS12;LOC729338 1.0 18.39 0.71 1.11e-52 Blood protein levels; LUSC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg06640241 chr16:89574553 SPG7 0.74 10.22 0.49 1.68e-21 Multiple myeloma (IgH translocation); LUSC cis rs79149102 0.579 rs74023908 chr15:75310710 T/C cg09165964 chr15:75287851 SCAMP5 -0.94 -9.09 -0.45 9.01e-18 Lung cancer; LUSC cis rs7246657 0.551 rs4806413 chr19:37617716 A/T cg23950597 chr19:37808831 NA -0.54 -5.86 -0.31 1.11e-8 Coronary artery calcification; LUSC cis rs9467711 0.606 rs34878490 chr6:26370572 C/T cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs600231 0.542 rs12360896 chr11:65238306 G/T cg17120908 chr11:65337727 SSSCA1 -0.62 -8.95 -0.44 2.47e-17 Bone mineral density; LUSC cis rs1443512 0.755 rs1373160 chr12:54340383 A/G cg17410650 chr12:54324560 NA -0.6 -10.04 -0.48 6.44e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg18681998 chr4:17616180 MED28 0.86 15.83 0.65 1.74e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4285028 0.747 rs6791882 chr3:121373058 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.92 -12.8 -0.57 8.41e-31 Multiple sclerosis; LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 14.01 0.61 2.15e-35 Platelet count; LUSC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg17252645 chr8:143867129 LY6D 0.38 6.68 0.34 1.01e-10 Urinary tract infection frequency; LUSC cis rs6772849 0.708 rs12491942 chr3:128421469 C/G cg08795948 chr3:128337044 NA 0.4 5.73 0.3 2.26e-8 Monocyte percentage of white cells;Monocyte count; LUSC cis rs2219968 0.676 rs2879369 chr8:78839710 C/T cg00738934 chr8:78996279 NA -0.35 -5.9 -0.31 8.72e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2204008 0.505 rs11182550 chr12:38570061 A/T cg13010199 chr12:38710504 ALG10B 0.47 7.14 0.36 6e-12 Bladder cancer; LUSC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg22875332 chr1:76189707 ACADM 0.84 15.1 0.64 1.28e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11098499 0.754 rs12711071 chr4:120240934 A/G cg09307838 chr4:120376055 NA 0.65 10.02 0.48 7.79e-21 Corneal astigmatism; LUSC cis rs17685 0.753 rs2868203 chr7:75680026 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.91 0.4 3.75e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7605827 0.930 rs722328 chr2:15657164 T/C cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg18827107 chr12:86230957 RASSF9 -0.46 -6.97 -0.36 1.74e-11 Major depressive disorder; LUSC cis rs854765 0.647 rs7212447 chr17:17987067 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.66 10.85 0.51 1.1e-23 Total body bone mineral density; LUSC cis rs7759001 0.817 rs4711149 chr6:27365845 C/A cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs7903847 0.642 rs11189183 chr10:99144321 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.07 -0.4 1.26e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg04369109 chr6:150039330 LATS1 -0.58 -8.62 -0.43 2.72e-16 Lung cancer; LUSC cis rs614226 1.000 rs541126 chr12:120972396 C/T cg27489772 chr12:121021490 NA -0.56 -7.39 -0.38 1.16e-12 Type 1 diabetes nephropathy; LUSC cis rs2857891 0.695 rs2346002 chr11:6987741 T/C cg14883916 chr11:6947541 ZNF215 0.42 5.65 0.3 3.39e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg24690094 chr11:67383802 NA -0.38 -7.41 -0.38 1.07e-12 Mean corpuscular volume; LUSC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.38 0.64 9.74e-41 Platelet count; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg15790184 chr11:494944 RNH1 0.53 5.75 0.3 1.97e-8 Body mass index; LUSC trans rs459571 0.959 rs408307 chr9:136892523 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.73 11.87 0.54 2.37e-27 Platelet distribution width; LUSC cis rs929354 0.713 rs6459733 chr7:156930550 G/C cg17757837 chr7:157058334 UBE3C 0.8 12.16 0.55 2.12e-28 Body mass index; LUSC cis rs5770917 1.000 rs12627787 chr22:51012381 C/T cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.67 -0.3 3.03e-8 Narcolepsy; LUSC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg22431228 chr1:16359049 CLCNKA 0.44 8.83 0.43 6.09e-17 Dilated cardiomyopathy; LUSC cis rs637571 0.510 rs4930320 chr11:65576788 C/G cg17985854 chr11:65770987 BANF1;EIF1AD -0.39 -6.91 -0.35 2.42e-11 Eosinophil percentage of white cells; LUSC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.18 -0.32 1.82e-9 Total body bone mineral density; LUSC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg18876405 chr7:65276391 NA -0.53 -8.44 -0.42 9.69e-16 Aortic root size; LUSC cis rs877282 0.898 rs36064821 chr10:760952 C/T cg17470449 chr10:769945 NA 0.52 7.39 0.38 1.16e-12 Uric acid levels; LUSC cis rs6028335 0.674 rs66513266 chr20:37597410 G/T cg27552599 chr20:37590471 DHX35 0.45 5.66 0.3 3.21e-8 Alcohol and nicotine co-dependence; LUSC cis rs7560272 0.723 rs1083919 chr2:73713863 C/G cg20560298 chr2:73613845 ALMS1 0.46 7.19 0.37 4.17e-12 Schizophrenia; LUSC cis rs10782582 0.617 rs1846233 chr1:76159354 C/T cg03433033 chr1:76189801 ACADM -0.46 -6.88 -0.35 2.95e-11 Daytime sleep phenotypes; LUSC cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.77 0.3 1.83e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4925114 0.532 rs11655029 chr17:17649172 T/C cg09796270 chr17:17721594 SREBF1 -0.43 -7.24 -0.37 3.15e-12 Body mass index; LUSC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg26335602 chr6:28129616 ZNF389 0.46 6.06 0.31 3.64e-9 Parkinson's disease; LUSC trans rs7647973 0.626 rs4855845 chr3:49687043 T/C cg21659725 chr3:3221576 CRBN -0.67 -7.77 -0.39 9.81e-14 Menarche (age at onset); LUSC cis rs9687065 1.000 rs78013255 chr5:148397622 T/C cg23229984 chr5:148520753 ABLIM3 -0.39 -5.8 -0.3 1.58e-8 Diastolic blood pressure; LUSC cis rs6005807 0.719 rs9625524 chr22:29052951 C/T cg12565055 chr22:29076175 TTC28 0.52 5.7 0.3 2.63e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs7291412 0.540 rs9627391 chr22:46447097 C/T cg00785112 chr22:46450059 C22orf26;LOC150381 0.34 5.7 0.3 2.57e-8 Dupuytren's disease;Subjective well-being; LUSC cis rs912057 0.932 rs1294404 chr6:6735022 G/A cg06612196 chr6:6737390 NA 0.52 9.7 0.47 9.06e-20 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs55871839 0.708 rs4738732 chr8:59809943 A/G cg07426533 chr8:59803705 TOX 0.36 5.82 0.3 1.36e-8 Pneumonia; LUSC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg21138405 chr5:131827807 IRF1 0.35 6.24 0.32 1.34e-9 Breast cancer;Mosquito bite size; LUSC cis rs950169 0.840 rs72748702 chr15:84915246 A/G cg12863693 chr15:85201151 NMB 0.36 7.35 0.37 1.56e-12 Schizophrenia; LUSC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg00484396 chr16:3507460 NAT15 -0.42 -6.79 -0.35 5.25e-11 Body mass index (adult); LUSC cis rs11153147 0.730 rs2798646 chr6:109310596 C/A cg05315195 chr6:109294784 ARMC2 0.51 5.65 0.3 3.43e-8 Mean corpuscular volume; LUSC cis rs6460942 0.643 rs80264734 chr7:12233800 T/A cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg07507251 chr3:52567010 NT5DC2 0.33 6.37 0.33 6.25e-10 Bipolar disorder; LUSC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg18180107 chr4:99064573 C4orf37 0.42 5.88 0.31 1.02e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs4343996 0.727 rs7798418 chr7:3387048 C/G cg21248987 chr7:3385318 SDK1 -0.35 -5.91 -0.31 8.23e-9 Motion sickness; LUSC cis rs7258465 1.000 rs76194 chr19:18630580 T/G cg06462663 chr19:18546047 ISYNA1 0.44 7.47 0.38 6.97e-13 Breast cancer; LUSC cis rs155346 1.000 rs7728075 chr5:139382353 G/A cg01090482 chr5:139365336 NRG2 -0.38 -6.21 -0.32 1.55e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs6163 0.508 rs12776506 chr10:104532828 A/G cg05855489 chr10:104503620 C10orf26 0.72 11.27 0.52 3.51e-25 Waist circumference;Hip circumference; LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.21 0.37 3.76e-12 Platelet count; LUSC cis rs4363385 0.626 rs6664183 chr1:153064002 A/G cg07796016 chr1:152779584 LCE1C -0.4 -6.25 -0.32 1.27e-9 Inflammatory skin disease; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg26338869 chr17:61819248 STRADA 0.41 6.02 0.31 4.68e-9 Prudent dietary pattern; LUSC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs877282 0.583 rs11253424 chr10:813426 C/T cg13775593 chr10:823151 NA 0.26 5.78 0.3 1.68e-8 Uric acid levels; LUSC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg22496339 chr2:162101262 NA 0.73 11.88 0.54 2.23e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg19748678 chr4:122722346 EXOSC9 0.5 7.67 0.39 1.86e-13 Type 2 diabetes; LUSC cis rs950169 0.922 rs2033284 chr15:84946273 C/T cg12863693 chr15:85201151 NMB 0.36 7.09 0.36 8e-12 Schizophrenia; LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.18 0.37 4.5e-12 Bipolar disorder; LUSC cis rs6138458 1.000 rs2387361 chr20:24899905 C/T cg26195577 chr20:24973756 C20orf3 -1.12 -18.25 -0.71 4.21e-52 Blood protein levels; LUSC cis rs4631830 0.863 rs7081532 chr10:51526093 A/G cg20129853 chr10:51489980 NA -0.33 -6.72 -0.35 7.66e-11 Prostate-specific antigen levels; LUSC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.18 -0.49 2.24e-21 Menarche (age at onset); LUSC cis rs11630290 0.736 rs4777370 chr15:64160104 G/A cg12036633 chr15:63758958 NA 0.59 6.4 0.33 5.39e-10 Iris characteristics; LUSC cis rs9549367 0.826 rs2287249 chr13:113889355 A/G cg00898013 chr13:113819073 PROZ -0.57 -8.09 -0.4 1.12e-14 Platelet distribution width; LUSC cis rs4474465 1.000 rs10899508 chr11:78170708 T/G cg27205649 chr11:78285834 NARS2 -0.48 -5.74 -0.3 2.14e-8 Alzheimer's disease (survival time); LUSC cis rs1996152 0.543 rs4789658 chr17:72389526 A/T cg23221732 chr17:72383708 NA 0.32 6.25 0.32 1.24e-9 Interleukin-12p70 levels; LUSC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg02187348 chr16:89574699 SPG7 -0.55 -8.91 -0.44 3.36e-17 Multiple myeloma (IgH translocation); LUSC cis rs9392556 0.829 rs853417 chr6:4113123 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.37 -6.46 -0.33 3.68e-10 Blood metabolite levels; LUSC cis rs709400 0.663 rs17617941 chr14:103953032 T/C cg10523860 chr14:103875565 MARK3 -0.37 -5.82 -0.3 1.37e-8 Body mass index; LUSC cis rs2688608 0.592 rs7908825 chr10:75554541 C/G cg17411546 chr10:75410026 SYNPO2L 0.52 7.98 0.4 2.41e-14 Inflammatory bowel disease; LUSC trans rs9291683 0.527 rs73212848 chr4:10093299 T/C cg26043149 chr18:55253948 FECH -0.49 -7.32 -0.37 1.92e-12 Bone mineral density; LUSC cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg05347473 chr6:146136440 FBXO30 -0.53 -9.0 -0.44 1.76e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.628 rs34237267 chr8:11197301 G/C cg21775007 chr8:11205619 TDH 0.81 13.85 0.6 8.77e-35 Retinal vascular caliber; LUSC cis rs7772486 0.712 rs1292335 chr6:145967877 G/T cg23711669 chr6:146136114 FBXO30 0.74 12.62 0.57 3.96e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs66887589 0.934 rs2389873 chr4:120554714 A/G cg09307838 chr4:120376055 NA -0.49 -7.48 -0.38 6.83e-13 Diastolic blood pressure; LUSC cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg05283184 chr6:79620031 NA -0.56 -11.74 -0.54 7.3e-27 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg15448220 chr1:150897856 SETDB1 0.43 6.22 0.32 1.45e-9 Melanoma; LUSC cis rs644799 0.672 rs11021347 chr11:95653494 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.27 0.52 3.5e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg25019033 chr10:957182 NA -0.53 -6.81 -0.35 4.62e-11 Eosinophil percentage of granulocytes; LUSC trans rs7824557 0.602 rs35807737 chr8:11204411 C/G cg15556689 chr8:8085844 FLJ10661 0.49 7.18 0.37 4.43e-12 Retinal vascular caliber; LUSC cis rs6594499 0.872 rs7723819 chr5:110427347 A/G cg04022379 chr5:110408740 TSLP -0.52 -7.77 -0.39 9.99e-14 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs4243830 0.850 rs4908910 chr1:6599362 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -9.64 -0.47 1.4e-19 Body mass index; LUSC cis rs1044826 0.642 rs6771831 chr3:139177585 C/T cg00490450 chr3:139108681 COPB2 0.46 6.98 0.36 1.63e-11 Obesity-related traits; LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs10782582 0.586 rs1856791 chr1:76308942 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.06 -0.36 9.81e-12 Daytime sleep phenotypes; LUSC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs12044355 0.896 rs12723735 chr1:231860372 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.4 5.69 0.3 2.74e-8 Alzheimer's disease; LUSC cis rs11105298 0.838 rs4842488 chr12:89881564 C/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.04e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg09323728 chr8:95962352 TP53INP1 0.37 7.08 0.36 8.39e-12 Type 2 diabetes; LUSC trans rs6502050 0.835 rs8065981 chr17:80091393 G/T cg07393940 chr7:158741817 NA 0.38 6.89 0.35 2.77e-11 Life satisfaction; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg09704166 chr2:114031854 PAX8;LOC440839 -0.57 -9.55 -0.46 2.94e-19 Lymphocyte counts; LUSC cis rs3806843 1.000 rs4151682 chr5:140201264 C/T cg26395211 chr5:140044315 WDR55 -0.37 -5.7 -0.3 2.69e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7267979 0.966 rs2227890 chr20:25260931 A/G cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.18e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg00012203 chr2:219082015 ARPC2 0.89 17.23 0.69 4.95e-48 Colorectal cancer; LUSC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg25566285 chr7:158114605 PTPRN2 0.33 6.07 0.32 3.43e-9 Calcium levels; LUSC cis rs9549367 0.713 rs2476328 chr13:113829350 C/T cg00898013 chr13:113819073 PROZ 0.55 7.96 0.4 2.76e-14 Platelet distribution width; LUSC cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.16e-9 Diabetic kidney disease; LUSC cis rs58950470 0.927 rs1193851 chr11:65386206 C/G cg05805236 chr11:65401703 PCNXL3 0.35 5.7 0.3 2.66e-8 Schizophrenia; LUSC cis rs4363385 0.773 rs310122 chr1:153064288 C/T cg00922841 chr1:152955080 SPRR1A 0.38 6.49 0.33 3.11e-10 Inflammatory skin disease; LUSC cis rs7106204 0.764 rs11821644 chr11:24212686 T/C ch.11.24196551F chr11:24239977 NA 0.93 7.86 0.39 5.41e-14 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2979489 0.945 rs34960391 chr8:30332723 G/A cg26383811 chr8:30366931 RBPMS -0.51 -8.03 -0.4 1.66e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs11031096 0.502 rs4910598 chr11:4101368 C/T cg18678763 chr11:4115507 RRM1 -0.48 -6.27 -0.32 1.09e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11155671 0.530 rs7764376 chr6:150210344 A/G cg09699651 chr6:150184138 LRP11 0.45 7.17 0.37 4.98e-12 Testicular germ cell tumor; LUSC trans rs2262909 1.000 rs2078089 chr19:22209753 A/T cg05197062 chr11:11642011 GALNTL4 -0.51 -7.08 -0.36 8.34e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4654899 0.606 rs651085 chr1:21097783 A/G cg01072550 chr1:21505969 NA 0.42 6.37 0.33 6.09e-10 Superior frontal gyrus grey matter volume; LUSC cis rs9467773 1.000 rs10946835 chr6:26533757 C/T cg09904177 chr6:26538194 HMGN4 0.76 14.42 0.62 5.75e-37 Intelligence (multi-trait analysis); LUSC trans rs72674100 1.000 rs2865754 chr4:97992711 T/C cg09670535 chr1:18959427 PAX7 -0.61 -6.27 -0.32 1.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs765787 0.556 rs2413778 chr15:45539397 C/A cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC cis rs7000551 0.751 rs2461482 chr8:22382898 C/T cg12081754 chr8:22256438 SLC39A14 0.46 6.82 0.35 4.23e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11098499 0.754 rs11098502 chr4:120252063 T/A cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg02753203 chr1:228287806 NA -0.65 -11.16 -0.52 8.28e-25 Diastolic blood pressure; LUSC cis rs11971779 0.523 rs10234578 chr7:139037988 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC trans rs4734806 0.579 rs72677051 chr8:105873452 C/G cg19267248 chr12:98849532 NA 0.39 6.06 0.31 3.58e-9 Periodontitis (DPAL); LUSC cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.1 -0.32 2.98e-9 Intelligence (multi-trait analysis); LUSC cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs62400317 0.859 rs12205379 chr6:45215074 G/A cg18551225 chr6:44695536 NA -0.44 -7.31 -0.37 2.04e-12 Total body bone mineral density; LUSC cis rs2295359 0.892 rs4655686 chr1:67638004 T/A cg17031739 chr1:67600172 NA 0.46 7.21 0.37 3.76e-12 Psoriasis; LUSC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg16447950 chr5:562315 NA -0.55 -6.79 -0.35 5.23e-11 Obesity-related traits; LUSC cis rs17227506 0.679 rs34216318 chr8:13444780 T/C cg03566418 chr8:13424080 C8orf48 0.4 6.13 0.32 2.52e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg27427491 chr17:78079615 GAA -0.36 -6.58 -0.34 1.83e-10 Yeast infection; LUSC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg06544989 chr22:39130855 UNC84B 0.34 5.81 0.3 1.45e-8 Menopause (age at onset); LUSC cis rs11031096 0.678 rs11031219 chr11:4197578 G/A cg18678763 chr11:4115507 RRM1 -0.4 -5.69 -0.3 2.75e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg08704250 chr15:31115839 NA 0.59 9.23 0.45 3.08e-18 Huntington's disease progression; LUSC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.63 -0.43 2.45e-16 Lung cancer; LUSC cis rs67072384 0.818 rs1872128 chr11:72465526 C/T cg04827223 chr11:72435913 ARAP1 -0.73 -6.35 -0.33 7.13e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs13315871 0.722 rs3952239 chr3:58312057 G/T cg20936604 chr3:58311152 NA -0.73 -7.06 -0.36 9.42e-12 Cholesterol, total; LUSC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg23283495 chr1:209979779 IRF6 0.66 7.9 0.4 4.2e-14 Coronary artery disease; LUSC cis rs1729951 0.546 rs12054219 chr3:136677472 G/A cg12473912 chr3:136751656 NA 0.38 6.75 0.35 6.7e-11 Neuroticism; LUSC cis rs4072705 0.646 rs2416933 chr9:127245529 C/T cg13476313 chr9:127244764 NR5A1 -0.32 -6.43 -0.33 4.48e-10 Menarche (age at onset); LUSC cis rs3126085 0.935 rs4421596 chr1:152181673 G/A cg03465714 chr1:152285911 FLG -0.42 -5.85 -0.3 1.17e-8 Atopic dermatitis; LUSC cis rs662064 1.000 rs662064 chr1:10557251 T/C cg17425144 chr1:10567563 PEX14 0.35 5.69 0.3 2.85e-8 Asthma; LUSC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs425277 0.958 rs262687 chr1:2117155 G/A cg03732007 chr1:2071316 PRKCZ 0.45 7.1 0.36 7.69e-12 Height; LUSC cis rs17818399 0.547 rs4952831 chr2:46761181 G/A cg21681030 chr2:46777652 RHOQ 0.46 6.35 0.33 7.24e-10 Height; LUSC cis rs9649465 0.551 rs10255400 chr7:123388036 G/A cg03229431 chr7:123269106 ASB15 -0.53 -8.58 -0.42 3.67e-16 Migraine; LUSC cis rs4253772 0.872 rs79700435 chr22:46638211 G/A cg09491104 chr22:46646882 C22orf40 -0.59 -6.44 -0.33 4.09e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg05868516 chr6:26286170 HIST1H4H -0.35 -5.78 -0.3 1.73e-8 Educational attainment; LUSC cis rs2354432 0.607 rs7553584 chr1:146693429 A/G cg25205988 chr1:146714368 CHD1L -1.09 -8.8 -0.43 7.74e-17 Mitochondrial DNA levels; LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.81 -0.3 1.43e-8 Platelet count; LUSC cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg05253716 chr12:129299332 SLC15A4;MGC16384 -0.46 -6.99 -0.36 1.5e-11 Systemic lupus erythematosus; LUSC cis rs12760731 0.668 rs4573483 chr1:178268075 C/A cg00404053 chr1:178313656 RASAL2 0.49 6.05 0.31 3.89e-9 Obesity-related traits; LUSC cis rs668210 0.947 rs559161 chr11:65761637 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.59 8.12 0.41 9.28e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg10018233 chr7:150070692 REPIN1 0.38 6.54 0.34 2.32e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg12463550 chr7:65579703 CRCP 0.47 6.78 0.35 5.51e-11 Aortic root size; LUSC cis rs1003719 0.788 rs2835599 chr21:38466937 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.24 0.52 4.48e-25 Eye color traits; LUSC cis rs1577917 0.816 rs9353349 chr6:86707725 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.12 0.41 9.26e-15 Response to antipsychotic treatment; LUSC trans rs4942242 0.663 rs34595450 chr13:44221245 A/G cg19169023 chr15:41853346 TYRO3 -0.6 -8.99 -0.44 1.81e-17 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9513627 1.000 rs9582302 chr13:100125985 A/T cg25919922 chr13:100150906 NA -0.74 -6.46 -0.33 3.69e-10 Obesity-related traits; LUSC cis rs8060686 0.641 rs113502835 chr16:68238965 A/T cg27539214 chr16:67997921 SLC12A4 -0.56 -7.19 -0.37 4.36e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs614226 0.516 rs1794748 chr12:120953758 A/G cg21053147 chr12:120880522 NA -0.49 -6.11 -0.32 2.77e-9 Type 1 diabetes nephropathy; LUSC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs55665837 1.000 rs3923294 chr11:14441402 T/G cg19336497 chr11:14380999 RRAS2 -0.37 -7.53 -0.38 4.9e-13 Vitamin D levels; LUSC cis rs6066835 1.000 rs73138221 chr20:47349525 T/C cg18078177 chr20:47281410 PREX1 0.75 6.33 0.33 7.83e-10 Multiple myeloma; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg26035463 chr12:117627651 FBXO21 0.44 6.09 0.32 3.05e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11250098 0.541 rs6997839 chr8:10766028 T/C cg21775007 chr8:11205619 TDH -0.5 -6.8 -0.35 4.83e-11 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.31 0.49 8.09e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9303401 0.614 rs62084387 chr17:57148027 C/T cg25039879 chr17:56429692 SUPT4H1 0.72 9.27 0.45 2.35e-18 Cognitive test performance; LUSC cis rs1160297 0.517 rs1451462 chr2:53123412 C/T cg07782112 chr2:53107842 NA -0.34 -5.74 -0.3 2.08e-8 Hemostatic factors and hematological phenotypes; LUSC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg21984481 chr17:79567631 NPLOC4 -0.73 -15.54 -0.65 2.39e-41 Eye color traits; LUSC cis rs753778 0.570 rs4961335 chr8:142209142 A/G cg18755752 chr8:142205143 DENND3 -0.68 -12.3 -0.56 6.23e-29 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs7267979 1.000 rs6037099 chr20:25356876 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg04267008 chr7:1944627 MAD1L1 0.45 6.48 0.33 3.28e-10 Schizophrenia; LUSC cis rs7829975 0.606 rs10112585 chr8:8795030 A/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.73 -0.35 7.4e-11 Mood instability; LUSC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg20891283 chr12:69753455 YEATS4 0.82 14.68 0.63 5.55e-38 Blood protein levels; LUSC cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.93 -0.4 3.37e-14 Chronic sinus infection; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg24675658 chr1:53192096 ZYG11B -0.68 -11.06 -0.52 1.93e-24 Monocyte count; LUSC cis rs2732480 0.577 rs1489109 chr12:48738780 C/A cg21466736 chr12:48725269 NA -0.32 -5.65 -0.3 3.49e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs656319 0.629 rs10111315 chr8:9865588 G/A cg21775007 chr8:11205619 TDH -0.43 -6.15 -0.32 2.26e-9 Myopia (pathological); LUSC trans rs1994135 0.647 rs1351681 chr12:33698724 G/A cg13010199 chr12:38710504 ALG10B 0.56 7.58 0.38 3.45e-13 Resting heart rate; LUSC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.24e-21 Bipolar disorder; LUSC cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg05294307 chr14:35346193 BAZ1A -0.57 -6.58 -0.34 1.82e-10 Psoriasis; LUSC cis rs877282 0.945 rs34367686 chr10:791868 G/C cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs9875589 0.509 rs11718142 chr3:14018793 G/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 6.83 0.35 3.91e-11 Ovarian reserve; LUSC cis rs7561273 0.586 rs13418279 chr2:24349218 G/T cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg09796270 chr17:17721594 SREBF1 -0.34 -5.97 -0.31 5.92e-9 Total body bone mineral density; LUSC cis rs1443512 0.812 rs2078098 chr12:54337527 C/A cg25024717 chr12:54324583 NA -0.38 -6.43 -0.33 4.51e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7481584 0.624 rs2106229 chr11:3041195 G/A cg25174290 chr11:3078921 CARS -0.42 -6.32 -0.33 8.33e-10 Calcium levels; LUSC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg04369109 chr6:150039330 LATS1 -0.54 -7.5 -0.38 5.75e-13 Lung cancer; LUSC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg11645453 chr3:52864694 ITIH4 -0.37 -8.11 -0.41 9.81e-15 Bipolar disorder; LUSC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 6.99 0.36 1.53e-11 Bipolar disorder; LUSC cis rs4974559 0.501 rs1250129 chr4:1254930 C/T cg02980000 chr4:1222292 CTBP1 0.62 6.98 0.36 1.6e-11 Systolic blood pressure; LUSC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg04369109 chr6:150039330 LATS1 -0.58 -8.42 -0.42 1.14e-15 Lung cancer; LUSC cis rs7945718 0.905 rs7124484 chr11:12745271 G/A cg25843174 chr11:12811716 TEAD1 0.33 7.31 0.37 2.03e-12 Educational attainment (years of education); LUSC cis rs6121246 0.567 rs7266471 chr20:30220599 T/A cg18721089 chr20:30220636 NA -0.39 -6.08 -0.32 3.28e-9 Mean corpuscular hemoglobin; LUSC cis rs926392 0.572 rs6129156 chr20:37672209 A/C cg16355469 chr20:37678765 NA 0.54 7.38 0.37 1.27e-12 Dialysis-related mortality; LUSC cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg06784218 chr1:46089804 CCDC17 0.51 10.03 0.48 7.26e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9467773 0.550 rs9379874 chr6:26440429 A/T cg09904177 chr6:26538194 HMGN4 -0.56 -8.68 -0.43 1.81e-16 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs12950390 0.853 rs56387656 chr17:45860189 C/G cg03474202 chr17:45855739 NA -0.3 -6.93 -0.35 2.14e-11 IgG glycosylation; LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.99 -0.48 9.74e-21 Platelet count; LUSC trans rs61931739 0.534 rs4547187 chr12:34041259 T/C cg13010199 chr12:38710504 ALG10B 0.52 7.89 0.4 4.44e-14 Morning vs. evening chronotype; LUSC cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -7.46 -0.38 7.67e-13 Schizophrenia; LUSC trans rs2204008 0.548 rs2320740 chr12:38166421 G/A cg06521331 chr12:34319734 NA -0.39 -6.1 -0.32 2.98e-9 Bladder cancer; LUSC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg09904177 chr6:26538194 HMGN4 -0.43 -6.69 -0.34 9.67e-11 Schizophrenia; LUSC cis rs713477 0.712 rs72717779 chr14:55893440 A/G cg13175173 chr14:55914753 NA -0.29 -5.97 -0.31 6.14e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs6840360 0.550 rs7683134 chr4:152503362 A/C cg22705602 chr4:152727874 NA -0.32 -6.51 -0.34 2.76e-10 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs7196823 chr16:48616278 G/A cg04672837 chr16:48644449 N4BP1 0.5 7.48 0.38 6.46e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs10843647 1.000 rs6416250 chr12:30325443 T/C cg12718339 chr12:29936407 TMTC1 -0.36 -5.94 -0.31 7.29e-9 Glucose homeostasis traits; LUSC cis rs8060686 0.516 rs4567701 chr16:68163662 T/C cg09835421 chr16:68378352 PRMT7 -0.48 -5.95 -0.31 6.7e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg05481257 chr2:20870211 GDF7 -0.37 -6.93 -0.35 2.12e-11 Abdominal aortic aneurysm; LUSC cis rs1865760 1.000 rs2071301 chr6:25914263 G/T cg16482183 chr6:26056742 HIST1H1C 0.46 6.89 0.35 2.72e-11 Height; LUSC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg04944784 chr2:26401820 FAM59B -0.7 -9.79 -0.47 4.69e-20 Gut microbiome composition (summer); LUSC cis rs2806561 1.000 rs2746553 chr1:23493246 T/C cg19743168 chr1:23544995 NA 0.43 9.3 0.45 1.9e-18 Height; LUSC cis rs4494114 1.000 rs9439082 chr1:39344055 G/A cg25970120 chr1:39325951 RRAGC -0.41 -6.47 -0.33 3.56e-10 Blood protein levels; LUSC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg16680214 chr1:154839983 KCNN3 -0.37 -6.51 -0.34 2.82e-10 Schizophrenia; LUSC cis rs4629180 0.586 rs1995826 chr2:102129420 A/G cg01388757 chr2:102091195 RFX8 0.34 5.79 0.3 1.63e-8 Chronic rhinosinusitis with nasal polyps; LUSC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg05110241 chr16:68378359 PRMT7 -0.59 -6.73 -0.35 7.4e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs4751006 0.543 rs7899778 chr10:128780419 A/C cg05702161 chr10:128779687 DOCK1 -0.78 -6.45 -0.33 3.87e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs28602670 1 rs28602670 chr15:78768167 C/G cg06917634 chr15:78832804 PSMA4 -0.48 -5.99 -0.31 5.45e-9 Post bronchodilator FEV1; LUSC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg05855489 chr10:104503620 C10orf26 -0.71 -10.34 -0.49 6.51e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7949030 0.929 rs11231173 chr11:62418921 T/A cg22862634 chr11:62369728 EML3;MTA2 0.49 7.81 0.39 7.3e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17540621 1.000 rs10193261 chr2:47239142 G/T cg23978866 chr2:47230407 TTC7A -0.76 -5.93 -0.31 7.55e-9 Response to statin therapy; LUSC cis rs7202877 0.706 rs1074961 chr16:75389484 C/T cg04384234 chr16:75411784 CFDP1 -0.63 -8.82 -0.43 6.31e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg18404041 chr3:52824283 ITIH1 -0.57 -11.03 -0.52 2.41e-24 Bipolar disorder; LUSC cis rs1595825 0.838 rs73058883 chr2:198896255 C/T cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23994917 chr2:232791126 NPPC -0.56 -6.54 -0.34 2.38e-10 Bipolar disorder and schizophrenia; LUSC cis rs79387448 0.745 rs72995658 chr2:103176773 A/G cg09003973 chr2:102972529 NA 0.87 8.27 0.41 3.3e-15 Gut microbiota (bacterial taxa); LUSC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg04362960 chr10:104952993 NT5C2 -0.61 -9.39 -0.46 9.32e-19 Waist circumference;Hip circumference; LUSC cis rs2762353 0.526 rs3936052 chr6:25715534 A/G cg16482183 chr6:26056742 HIST1H1C 0.43 6.11 0.32 2.7e-9 Blood metabolite levels; LUSC cis rs9814567 1.000 rs9819532 chr3:134288644 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.05 -0.61 1.51e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs5769765 0.671 rs138817 chr22:50163058 G/A cg26441486 chr22:50317300 CRELD2 0.43 6.6 0.34 1.63e-10 Schizophrenia; LUSC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg21963583 chr11:68658836 MRPL21 0.6 8.93 0.44 2.86e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg21951975 chr1:209979733 IRF6 0.57 8.52 0.42 5.74e-16 Cleft lip with or without cleft palate; LUSC cis rs11167764 1.000 rs6580220 chr5:141480558 G/A cg08523384 chr5:141488047 NDFIP1 -0.51 -7.45 -0.38 8.09e-13 Crohn's disease; LUSC cis rs2559856 1.000 rs10860771 chr12:102087242 A/G cg12924262 chr12:102091054 CHPT1 0.43 6.04 0.31 4e-9 Blood protein levels; LUSC cis rs2692947 0.628 rs1997257 chr2:96429625 A/G cg22654517 chr2:96458247 NA 0.38 7.64 0.39 2.34e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9300255 0.544 rs10772995 chr12:123671761 T/C cg05973401 chr12:123451056 ABCB9 0.53 6.51 0.34 2.82e-10 Neutrophil percentage of white cells; LUSC cis rs9427116 0.532 rs9426828 chr1:154591489 G/A cg17218026 chr1:154582156 ADAR 0.57 10.26 0.49 1.18e-21 Blood protein levels; LUSC cis rs34779708 0.966 rs6481941 chr10:35440141 G/A cg04310649 chr10:35416472 CREM -0.41 -6.42 -0.33 4.65e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs1325195 0.537 rs931441 chr1:179189845 C/G cg11624085 chr17:8464688 MYH10 0.44 6.35 0.33 6.94e-10 IgE grass sensitization; LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg11494091 chr17:61959527 GH2 0.71 15.15 0.64 7.61e-40 Prudent dietary pattern; LUSC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg15744005 chr10:104629667 AS3MT -0.35 -7.13 -0.36 6.22e-12 Arsenic metabolism; LUSC cis rs2075671 0.903 rs62482250 chr7:100266057 C/T cg20848291 chr7:100343083 ZAN -0.6 -8.03 -0.4 1.73e-14 Other erythrocyte phenotypes; LUSC cis rs9549367 0.713 rs9577211 chr13:113830718 G/C cg18105134 chr13:113819100 PROZ -0.71 -10.49 -0.5 1.89e-22 Platelet distribution width; LUSC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg22963979 chr7:1858916 MAD1L1 0.49 7.3 0.37 2.08e-12 Schizophrenia; LUSC cis rs3824867 0.920 rs7105122 chr11:47449544 A/G cg20307385 chr11:47447363 PSMC3 0.64 9.54 0.46 3.12e-19 Mean corpuscular hemoglobin; LUSC cis rs929354 0.772 rs6459738 chr7:156998532 T/G cg17757837 chr7:157058334 UBE3C 0.83 13.32 0.59 9.66e-33 Body mass index; LUSC cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.08 21.02 0.75 4.3e-63 Cognitive ability; LUSC cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg14416269 chr4:6271139 WFS1 0.54 11.41 0.53 1.08e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg08677398 chr8:58056175 NA 0.47 5.94 0.31 7.29e-9 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg13939156 chr17:80058883 NA 0.38 7.34 0.37 1.65e-12 Life satisfaction; LUSC cis rs12908161 1.000 rs11638290 chr15:85227636 C/T cg17507749 chr15:85114479 UBE2QP1 0.56 6.96 0.36 1.8e-11 Schizophrenia; LUSC cis rs2996428 0.504 rs3765780 chr1:3767696 C/T cg13057898 chr1:3703894 LRRC47 -0.35 -6.68 -0.34 1.01e-10 Red cell distribution width; LUSC trans rs11098499 0.570 rs6832740 chr4:120546136 T/C cg25214090 chr10:38739885 LOC399744 0.42 6.49 0.33 3.18e-10 Corneal astigmatism; LUSC trans rs62238980 0.614 rs76161060 chr22:32383153 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs2243480 1.000 rs55895244 chr7:65387678 C/G cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs921968 0.643 rs590771 chr2:219369851 C/T cg02176678 chr2:219576539 TTLL4 0.64 11.53 0.53 4.11e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg22868518 chr11:507468 RNH1 -0.59 -5.8 -0.3 1.56e-8 Body mass index; LUSC cis rs3768617 0.706 rs10797801 chr1:182971965 G/T ch.1.3577855R chr1:183094577 LAMC1 0.58 8.44 0.42 9.48e-16 Fuchs's corneal dystrophy; LUSC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg17385448 chr1:15911702 AGMAT 0.37 6.15 0.32 2.19e-9 Systolic blood pressure; LUSC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg04455712 chr21:45112962 RRP1B 0.46 8.72 0.43 1.31e-16 Mean corpuscular volume; LUSC cis rs9910055 0.614 rs12944572 chr17:42245241 T/C cg19774624 chr17:42201019 HDAC5 -0.81 -13.61 -0.6 7.03e-34 Total body bone mineral density; LUSC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.76 -0.35 6.19e-11 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg13390004 chr1:15929781 NA 0.42 6.96 0.36 1.77e-11 Systolic blood pressure; LUSC cis rs1712517 0.771 rs59744322 chr10:105146692 G/T cg05636881 chr10:105038444 INA 0.4 6.71 0.34 8.14e-11 Migraine; LUSC trans rs10090774 0.965 rs11777839 chr8:141917894 G/T cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 5.99 0.31 5.53e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg08392591 chr16:89556376 ANKRD11 0.44 6.58 0.34 1.86e-10 Multiple myeloma (IgH translocation); LUSC cis rs7123876 0.553 rs12099027 chr11:72433920 A/G cg03713592 chr11:72463424 ARAP1 0.49 7.0 0.36 1.38e-11 Body mass index; LUSC cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg06784218 chr1:46089804 CCDC17 0.54 10.6 0.5 8.22e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg03146154 chr1:46216737 IPP 0.55 8.35 0.42 1.78e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg16049864 chr8:95962084 TP53INP1 -0.5 -8.17 -0.41 6.32e-15 Type 2 diabetes; LUSC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs60154123 0.614 rs645311 chr1:210459984 A/C cg22029157 chr1:209979665 IRF6 0.52 5.93 0.31 7.46e-9 Coronary artery disease; LUSC cis rs4740619 0.875 rs6474966 chr9:15757537 G/A cg14451791 chr9:16040625 NA -0.3 -5.73 -0.3 2.28e-8 Body mass index; LUSC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs5769707 0.616 rs6009786 chr22:50015145 A/G cg20744362 chr22:50050164 C22orf34 0.39 7.11 0.36 6.99e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.74 10.97 0.51 4.21e-24 Cognitive test performance; LUSC cis rs7572733 0.534 rs700678 chr2:198705820 T/C cg00792783 chr2:198669748 PLCL1 0.44 5.84 0.3 1.21e-8 Dermatomyositis; LUSC cis rs955333 0.850 rs12525852 chr6:154917060 A/G cg20019720 chr6:154832845 CNKSR3 0.49 6.2 0.32 1.68e-9 Diabetic kidney disease; LUSC cis rs4654899 0.865 rs61779065 chr1:21356474 A/T cg02927042 chr1:21476669 EIF4G3 -0.41 -6.41 -0.33 4.83e-10 Superior frontal gyrus grey matter volume; LUSC cis rs9549260 0.609 rs9315781 chr13:41264053 T/C cg21288729 chr13:41239152 FOXO1 0.56 8.31 0.41 2.36e-15 Red blood cell count; LUSC cis rs7677751 0.747 rs1800809 chr4:55093914 A/G cg17187183 chr4:55093834 PDGFRA 0.39 5.89 0.31 9.61e-9 Corneal astigmatism; LUSC cis rs7100689 0.784 rs4934139 chr10:82177023 C/A cg01528321 chr10:82214614 TSPAN14 1.07 16.88 0.68 1.16e-46 Post bronchodilator FEV1; LUSC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg07959070 chr22:50026188 C22orf34 -0.36 -7.39 -0.37 1.18e-12 Monocyte count;Monocyte percentage of white cells; LUSC trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg23505145 chr19:12996616 KLF1 0.64 10.81 0.51 1.51e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg09323728 chr8:95962352 TP53INP1 -0.38 -7.58 -0.38 3.46e-13 Type 2 diabetes; LUSC cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg15744005 chr10:104629667 AS3MT -0.34 -6.96 -0.36 1.83e-11 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.679 rs6686286 chr1:152984562 T/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.48 -0.38 6.47e-13 Inflammatory skin disease; LUSC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg06713675 chr4:122721982 EXOSC9 -0.66 -11.39 -0.53 1.32e-25 Type 2 diabetes; LUSC cis rs727505 0.754 rs55905546 chr7:124783064 A/C cg23710748 chr7:124431027 NA -0.41 -7.13 -0.36 6.4e-12 Lewy body disease; LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.07 -0.36 8.84e-12 Major depressive disorder; LUSC cis rs10072221 0.836 rs13357820 chr5:75698761 G/T cg03132911 chr5:75698732 IQGAP2 0.38 6.35 0.33 6.89e-10 Mean platelet volume; LUSC cis rs1062746 0.502 rs76128303 chr16:87339236 T/C cg02258303 chr16:87377426 FBXO31 -0.53 -8.07 -0.4 1.24e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs2625529 0.938 rs4238447 chr15:72131880 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.43 -0.38 9.31e-13 Red blood cell count; LUSC cis rs7605827 0.893 rs4668929 chr2:15719044 C/A cg19274914 chr2:15703543 NA 0.45 8.41 0.42 1.24e-15 Educational attainment (years of education); LUSC cis rs10754283 0.901 rs10047070 chr1:90098715 G/C cg21401794 chr1:90099060 LRRC8C 0.66 10.03 0.48 7.43e-21 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs950027 0.620 rs35861938 chr15:45637343 T/C cg14582100 chr15:45693742 SPATA5L1 0.44 8.43 0.42 1.07e-15 Response to fenofibrate (adiponectin levels); LUSC cis rs62400317 0.762 rs12212190 chr6:44926271 T/C cg20913747 chr6:44695427 NA -0.46 -7.3 -0.37 2.16e-12 Total body bone mineral density; LUSC cis rs8060686 0.545 rs117751972 chr16:68171968 C/T cg09835421 chr16:68378352 PRMT7 -0.59 -6.21 -0.32 1.55e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11890956 chr21:40555474 PSMG1 -0.73 -11.01 -0.52 2.85e-24 Menarche (age at onset); LUSC cis rs3931020 0.657 rs277369 chr1:75234661 T/C cg21535942 chr1:75199100 CRYZ;TYW3 -0.46 -5.78 -0.3 1.7e-8 Resistin levels; LUSC cis rs7312933 0.618 rs7315968 chr12:42637086 G/A cg01256987 chr12:42539512 GXYLT1 -0.41 -7.6 -0.38 3.08e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2251381 0.520 rs873651 chr21:30781848 G/A cg24692254 chr21:30365293 RNF160 0.67 10.28 0.49 1e-21 Selective IgA deficiency; LUSC trans rs11098499 0.954 rs71629403 chr4:120372567 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs12908161 1.000 rs11637142 chr15:85295927 A/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.66 0.34 1.15e-10 Schizophrenia; LUSC cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg14416269 chr4:6271139 WFS1 0.54 11.72 0.54 8.55e-27 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg13453750 chr1:205783389 SLC41A1 -0.33 -6.51 -0.34 2.82e-10 Menarche (age at onset); LUSC cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg07606381 chr6:8435919 SLC35B3 0.73 12.64 0.57 3.36e-30 Motion sickness; LUSC cis rs3845702 0.736 rs12693214 chr2:180825685 G/A cg01881094 chr2:180872142 CWC22 -1.06 -12.75 -0.57 1.28e-30 Schizophrenia; LUSC cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg16230307 chr14:35515116 FAM177A1 0.74 8.83 0.43 6.15e-17 Psoriasis; LUSC trans rs953492 0.701 rs1796846 chr1:243306924 A/G cg25284624 chr1:224180302 NA -0.47 -7.55 -0.38 4.33e-13 Diastolic blood pressure; LUSC trans rs61931739 0.500 rs11053197 chr12:34441949 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.75 0.65 3.58e-42 Morning vs. evening chronotype; LUSC cis rs929354 1.000 rs1182452 chr7:157053618 G/A cg05182265 chr7:156933206 UBE3C 0.45 6.84 0.35 3.68e-11 Body mass index; LUSC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg16405210 chr4:1374714 KIAA1530 -0.6 -9.42 -0.46 7.56e-19 Obesity-related traits; LUSC cis rs6500602 0.647 rs4786501 chr16:4536165 G/T cg08645402 chr16:4508243 NA -0.5 -8.46 -0.42 8.63e-16 Schizophrenia; LUSC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg19468946 chr17:37922297 IKZF3 -0.44 -6.86 -0.35 3.33e-11 Self-reported allergy; LUSC cis rs7903847 0.612 rs9887994 chr10:99159815 T/G cg20016023 chr10:99160130 RRP12 -0.25 -5.73 -0.3 2.25e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.3 -5.73 -0.3 2.2e-8 Lymphocyte counts; LUSC cis rs2274273 0.837 rs8008119 chr14:55831228 T/C cg04306507 chr14:55594613 LGALS3 0.53 11.91 0.55 1.69e-27 Protein biomarker; LUSC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08704250 chr15:31115839 NA -0.47 -7.07 -0.36 9.16e-12 Huntington's disease progression; LUSC cis rs4073582 0.595 rs801737 chr11:65928193 T/C cg14036092 chr11:66035641 RAB1B 0.4 5.67 0.3 3.09e-8 Gout; LUSC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg08645402 chr16:4508243 NA 0.46 7.25 0.37 2.89e-12 Schizophrenia; LUSC cis rs17125944 0.505 rs77433996 chr14:53212263 G/A cg00686598 chr14:53173677 PSMC6 1.1 10.29 0.49 9.08e-22 Alzheimer's disease (late onset); LUSC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg24399712 chr22:39784796 NA 0.59 10.59 0.5 8.47e-23 IgG glycosylation; LUSC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg06074448 chr4:187884817 NA -0.38 -6.42 -0.33 4.77e-10 Lobe attachment (rater-scored or self-reported); LUSC trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg03929089 chr4:120376271 NA -0.77 -10.43 -0.5 3.05e-22 Coronary artery disease; LUSC cis rs77741769 0.571 rs12822123 chr12:121298644 C/T cg02419362 chr12:121203948 SPPL3 0.46 8.57 0.42 3.87e-16 Mean corpuscular volume; LUSC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg16393715 chr7:1948819 MAD1L1 0.35 5.98 0.31 5.68e-9 Bipolar disorder and schizophrenia; LUSC trans rs2840044 1.000 rs225243 chr17:33947212 A/G cg19694781 chr19:47549865 TMEM160 -0.58 -9.38 -0.46 1.03e-18 Response to radiotherapy in cancer (late toxicity); LUSC cis rs3008870 0.755 rs2815365 chr1:67499628 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.54 0.57 8.04e-30 Lymphocyte percentage of white cells; LUSC cis rs7267979 1.000 rs2500448 chr20:25404027 A/C cg03522245 chr20:25566470 NINL -0.35 -5.7 -0.3 2.58e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7678296 0.649 rs4585313 chr4:37240236 C/T cg06805348 chr4:37245195 KIAA1239 -0.55 -5.82 -0.3 1.4e-8 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs950027 0.620 rs1153860 chr15:45636584 A/G cg21132104 chr15:45694354 SPATA5L1 -0.42 -6.42 -0.33 4.8e-10 Response to fenofibrate (adiponectin levels); LUSC cis rs7647973 0.560 rs77473999 chr3:49777660 T/C cg13072238 chr3:49761600 GMPPB 0.69 8.74 0.43 1.18e-16 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18594562 chr20:57797677 ZNF831 0.4 6.19 0.32 1.72e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg27286337 chr10:134555280 INPP5A 0.92 12.05 0.55 5.3e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs2717463 1.000 rs10862109 chr12:80816877 C/T cg24988884 chr13:30424332 UBL3 -0.48 -5.96 -0.31 6.46e-9 Positive affect; LUSC trans rs2975734 0.736 rs4841300 chr8:10112595 T/C cg15556689 chr8:8085844 FLJ10661 -0.5 -6.33 -0.33 7.9e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs734999 0.566 rs4648658 chr1:2560882 G/A cg18854424 chr1:2615690 NA -0.52 -10.74 -0.51 2.56e-23 Ulcerative colitis; LUSC cis rs9283706 0.562 rs6881240 chr5:66331471 G/A cg11590213 chr5:66331682 MAST4 0.45 6.81 0.35 4.55e-11 Coronary artery disease; LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg00166722 chr3:10149974 C3orf24 0.63 8.63 0.43 2.63e-16 Alzheimer's disease; LUSC cis rs11785693 0.862 rs62491171 chr8:4987177 G/A cg26367366 chr8:4980734 NA 0.75 8.88 0.44 4.3e-17 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg21951975 chr1:209979733 IRF6 0.58 7.24 0.37 3.05e-12 Cleft lip with or without cleft palate; LUSC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg19230755 chr7:65878503 NA -0.43 -5.96 -0.31 6.34e-9 Aortic root size; LUSC cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg02175503 chr12:58329896 NA 0.6 8.9 0.44 3.53e-17 Intelligence (multi-trait analysis); LUSC cis rs17345786 0.511 rs12639028 chr3:101346033 G/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 11.71 0.54 9.32e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs1395 0.710 rs2083363 chr2:27475318 G/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.57 0.38 3.75e-13 Blood metabolite levels; LUSC cis rs2970818 0.831 rs2970808 chr12:4640362 C/T cg11146114 chr12:4671731 NA -0.56 -5.82 -0.3 1.39e-8 Phosphorus levels; LUSC cis rs12200560 0.505 rs2387378 chr6:97077504 C/A cg06623918 chr6:96969491 KIAA0776 0.5 7.21 0.37 3.75e-12 Coronary heart disease; LUSC cis rs7617773 0.779 rs11718329 chr3:48309828 C/G cg20734569 chr3:48348370 SPINK8 -0.48 -8.34 -0.42 2.01e-15 Coronary artery disease; LUSC cis rs1965732 0.917 rs9750735 chr2:3708383 A/T cg00999904 chr2:3704751 ALLC -0.33 -5.98 -0.31 5.68e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2019216 0.500 rs12450390 chr17:21910636 G/T cg22648282 chr17:21454238 C17orf51 -0.51 -7.51 -0.38 5.52e-13 Pelvic organ prolapse; LUSC cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg06627557 chr7:32535165 LSM5;AVL9 1.06 20.42 0.75 9.92e-61 Cognitive ability; LUSC cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg24130564 chr14:104152367 KLC1 -0.42 -6.08 -0.32 3.38e-9 Body mass index; LUSC cis rs7592578 0.882 rs16832765 chr2:191468762 T/C cg10560079 chr2:191398806 TMEM194B -0.67 -7.99 -0.4 2.25e-14 Diastolic blood pressure; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26606899 chr16:1802252 MAPK8IP3 -0.74 -6.05 -0.31 3.87e-9 Cognitive performance; LUSC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.52 0.34 2.6200000000000003e-10 Electroencephalogram traits; LUSC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg03233332 chr7:66118400 NA 0.4 5.91 0.31 8.36e-9 Aortic root size; LUSC cis rs10779751 0.960 rs12739368 chr1:11288247 T/C cg08854313 chr1:11322531 MTOR 0.88 14.87 0.63 9.44e-39 Body mass index; LUSC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg06112835 chr11:68658793 MRPL21 0.52 7.93 0.4 3.43e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg11266682 chr4:10021025 SLC2A9 0.52 9.05 0.44 1.17e-17 Bone mineral density; LUSC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg03806693 chr22:41940476 POLR3H -1.04 -14.65 -0.63 7.34e-38 Vitiligo; LUSC cis rs7605827 0.930 rs6431706 chr2:15600019 C/T cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.55e-18 Educational attainment (years of education); LUSC cis rs8072100 0.666 rs9913503 chr17:45776330 T/G cg08085267 chr17:45401833 C17orf57 -0.46 -6.66 -0.34 1.15e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6960043 0.738 rs7798360 chr7:15055972 A/G cg19272540 chr7:15055459 NA 0.35 8.57 0.42 3.95e-16 Type 2 diabetes; LUSC cis rs892961 0.932 rs7222170 chr17:75413096 G/A cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg13395646 chr4:1353034 KIAA1530 -0.62 -9.81 -0.47 3.86e-20 Obesity-related traits; LUSC cis rs4654899 0.680 rs3125160 chr1:21127803 G/C cg01072550 chr1:21505969 NA 0.46 6.83 0.35 4.01e-11 Superior frontal gyrus grey matter volume; LUSC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22590775 chr19:49891494 CCDC155 0.61 8.79 0.43 8.23e-17 Multiple sclerosis; LUSC cis rs10751667 1.000 rs7396366 chr11:986185 C/A cg06064525 chr11:970664 AP2A2 -0.37 -7.16 -0.36 5.31e-12 Alzheimer's disease (late onset); LUSC cis rs7119167 0.686 rs1894076 chr11:73035296 C/T cg17517138 chr11:73019481 ARHGEF17 0.49 5.73 0.3 2.3e-8 Blood protein levels; LUSC trans rs10432489 0.708 rs4290619 chr2:181766959 G/T cg04744134 chr19:8408128 KANK3 -0.84 -6.25 -0.32 1.24e-9 QT interval; LUSC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg06221963 chr1:154839813 KCNN3 -0.63 -14.35 -0.62 1.03e-36 Prostate cancer; LUSC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg19680485 chr15:31195859 MTMR15 0.5 6.58 0.34 1.86e-10 Huntington's disease progression; LUSC cis rs537626 0.767 rs680618 chr11:69316881 T/C cg08353955 chr11:69289746 NA -0.39 -5.97 -0.31 6.18e-9 Breast cancer (early onset); LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg02951883 chr7:2050386 MAD1L1 -0.65 -12.72 -0.57 1.7e-30 Bipolar disorder and schizophrenia; LUSC trans rs1325195 0.920 rs1858551 chr1:179089213 C/T cg11624085 chr17:8464688 MYH10 -0.44 -7.38 -0.37 1.25e-12 IgE grass sensitization; LUSC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs497273 0.552 rs1179939 chr12:121326876 G/C cg02419362 chr12:121203948 SPPL3 -0.43 -7.83 -0.39 6.7e-14 Systemic lupus erythematosus; LUSC cis rs4595586 0.563 rs11169769 chr12:39233134 C/G cg26384229 chr12:38710491 ALG10B 0.79 11.93 0.55 1.47e-27 Morning vs. evening chronotype; LUSC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg18402987 chr7:1209562 NA 0.42 5.67 0.3 3.03e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12310956 0.510 rs1565026 chr12:33887499 A/G cg06521331 chr12:34319734 NA -0.35 -5.75 -0.3 2.06e-8 Morning vs. evening chronotype; LUSC cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg14530993 chr4:882597 GAK 0.72 7.41 0.38 1.07e-12 Intelligence (multi-trait analysis); LUSC cis rs41271473 0.948 rs11585206 chr1:228824848 C/T cg10167378 chr1:228756711 NA 0.6 7.05 0.36 1.05e-11 Chronic lymphocytic leukemia; LUSC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg08975724 chr8:8085496 FLJ10661 0.52 7.98 0.4 2.33e-14 Mood instability; LUSC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg03806693 chr22:41940476 POLR3H -1.04 -13.97 -0.61 2.92e-35 Vitiligo; LUSC trans rs6502050 0.799 rs34448080 chr17:80121275 A/G cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs2708977 0.933 rs2708976 chr2:97184532 C/G cg01950434 chr2:97203154 ARID5A -0.54 -8.05 -0.4 1.47e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs7089973 0.668 rs61868024 chr10:116637939 A/G cg03647239 chr10:116582469 FAM160B1 0.43 6.56 0.34 2.09e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6121246 0.529 rs6060359 chr20:30209740 A/G cg21427119 chr20:30132790 HM13 -0.44 -6.17 -0.32 1.96e-9 Mean corpuscular hemoglobin; LUSC cis rs477692 0.905 rs524545 chr10:131411840 A/C cg05714579 chr10:131428358 MGMT -0.53 -8.06 -0.4 1.33e-14 Response to temozolomide; LUSC cis rs2742417 1.000 rs2742368 chr3:45752293 C/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg18000306 chr6:288505 NA 0.33 6.38 0.33 6.04e-10 Menopause (age at onset); LUSC cis rs6964587 0.626 rs7807765 chr7:91531974 C/A cg17063962 chr7:91808500 NA -0.57 -9.29 -0.45 2e-18 Breast cancer; LUSC cis rs1568889 0.838 rs7952717 chr11:28261658 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 12.81 0.57 7.89e-31 Bipolar disorder; LUSC cis rs1538970 1.000 rs2492840 chr1:45849792 C/A cg05343316 chr1:45956843 TESK2 0.6 8.57 0.42 3.93e-16 Platelet count; LUSC cis rs34779708 0.931 rs12240347 chr10:35359475 A/G cg04310649 chr10:35416472 CREM -0.41 -6.44 -0.33 4.26e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7246967 0.673 rs12985825 chr19:22953451 A/C cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs9584850 0.834 rs745638 chr13:99119307 C/G cg20487152 chr13:99095054 FARP1 -0.39 -6.44 -0.33 4.24e-10 Neuroticism; LUSC cis rs7428496 0.528 rs1129391 chr3:142283766 T/C cg16271453 chr3:142027066 XRN1 -0.5 -8.72 -0.43 1.33e-16 Mean corpuscular hemoglobin; LUSC cis rs9462027 0.606 rs4624858 chr6:34802301 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.46e-9 Systemic lupus erythematosus; LUSC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg09323728 chr8:95962352 TP53INP1 -0.45 -9.42 -0.46 7.83e-19 Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11971478 chr17:38375459 WIPF2 -0.4 -6.04 -0.31 4.09e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7084402 1.000 rs1863664 chr10:60266839 A/G cg07615347 chr10:60278583 BICC1 -0.35 -5.76 -0.3 1.95e-8 Refractive error; LUSC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -17.16 -0.68 8.97e-48 Primary sclerosing cholangitis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01813165 chr2:202646406 ALS2 0.44 6.51 0.34 2.81e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6087990 0.806 rs6088008 chr20:31382860 A/G cg13636640 chr20:31349939 DNMT3B 0.87 17.74 0.7 4.6e-50 Ulcerative colitis; LUSC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg26839252 chr6:160211577 TCP1;MRPL18 -0.5 -6.42 -0.33 4.8e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs11098499 0.754 rs10213267 chr4:120239074 A/G cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06830555 chr3:18486241 NA -0.4 -5.95 -0.31 6.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9473147 0.543 rs9369716 chr6:47552180 A/T cg02130027 chr6:47444894 CD2AP 0.35 5.7 0.3 2.67e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs72781680 0.821 rs17046004 chr2:24144873 A/G cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC cis rs854765 0.547 rs2955370 chr17:17966945 C/T cg16928487 chr17:17741425 SREBF1 0.37 7.11 0.36 6.87e-12 Total body bone mineral density; LUSC cis rs6964587 1.000 rs415 chr7:91580490 A/G cg17063962 chr7:91808500 NA -0.58 -9.02 -0.44 1.53e-17 Breast cancer; LUSC cis rs10197940 0.662 rs4467261 chr2:152281391 G/C cg19508488 chr2:152266495 RIF1 0.45 6.38 0.33 5.89e-10 Lung cancer; LUSC cis rs13315871 1.000 rs9850717 chr3:58351875 C/T cg12435725 chr3:58293450 RPP14 -0.6 -6.35 -0.33 6.95e-10 Cholesterol, total; LUSC cis rs9910055 0.659 rs721769 chr17:42261588 T/G cg09913183 chr17:42254507 C17orf65;ASB16 0.56 8.68 0.43 1.73e-16 Total body bone mineral density; LUSC cis rs68170813 0.617 rs7797791 chr7:107197222 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.47 -5.71 -0.3 2.43e-8 Coronary artery disease; LUSC cis rs2637266 0.756 rs2583064 chr10:78557708 A/G cg18941641 chr10:78392320 NA 0.37 6.7 0.34 8.79e-11 Pulmonary function; LUSC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg06134567 chr22:46658398 PKDREJ -0.46 -5.65 -0.3 3.37e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg01657329 chr11:68192670 LRP5 -0.45 -7.17 -0.37 4.75e-12 Total body bone mineral density; LUSC cis rs7267979 0.899 rs2104734 chr20:25526668 A/G cg08601574 chr20:25228251 PYGB 0.39 5.96 0.31 6.48e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg05347473 chr6:146136440 FBXO30 -0.57 -9.83 -0.47 3.34e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs34779708 0.931 rs34815241 chr10:35296676 T/C cg04310649 chr10:35416472 CREM -0.4 -6.19 -0.32 1.72e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.48e-24 Aortic root size; LUSC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.45 6.65 0.34 1.18e-10 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs7917772 0.582 rs12784963 chr10:104336986 G/A cg05855489 chr10:104503620 C10orf26 0.49 7.57 0.38 3.79e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs1005277 0.579 rs1740747 chr10:38520465 G/A cg17830980 chr10:43048298 ZNF37B -0.58 -9.51 -0.46 3.89e-19 Extrinsic epigenetic age acceleration; LUSC cis rs807669 0.835 rs698423 chr22:19197896 T/C cg02655711 chr22:19163373 SLC25A1 0.9 17.09 0.68 1.69e-47 Metabolite levels; LUSC cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.94 -0.44 2.75e-17 Breast cancer; LUSC cis rs17824933 0.848 rs11230564 chr11:60776465 A/G cg16817237 chr11:60793675 NA 0.39 6.17 0.32 1.98e-9 Multiple sclerosis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg25104457 chr1:26201866 NA -0.43 -6.18 -0.32 1.91e-9 Hepatitis; LUSC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -6.04 -0.31 4.17e-9 Reticulocyte fraction of red cells; LUSC trans rs1814175 0.541 rs12287397 chr11:49819799 G/A cg15704280 chr7:45808275 SEPT13 -1.13 -24.37 -0.8 4.1e-76 Height; LUSC cis rs4808199 0.948 rs2023883 chr19:19405480 G/A cg03709012 chr19:19516395 GATAD2A 0.97 11.75 0.54 6.71e-27 Nonalcoholic fatty liver disease; LUSC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12824058 0.816 rs1874522 chr12:130816536 C/T cg23887609 chr12:130822674 PIWIL1 -0.45 -6.89 -0.35 2.83e-11 Menopause (age at onset); LUSC cis rs7178572 1.000 rs8024485 chr15:77718368 C/A cg22256960 chr15:77711686 NA -0.54 -9.02 -0.44 1.51e-17 Type 2 diabetes; LUSC cis rs10927875 0.619 rs7537101 chr1:16150384 T/C cg21385522 chr1:16154831 NA -0.65 -10.85 -0.51 1.06e-23 Dilated cardiomyopathy; LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg21782813 chr7:2030301 MAD1L1 0.43 7.06 0.36 9.77e-12 Bipolar disorder and schizophrenia; LUSC cis rs7465272 1.000 rs13258638 chr8:143683582 C/T cg10104451 chr8:143696006 ARC -0.64 -8.88 -0.44 4.34e-17 Bipolar disorder and schizophrenia; LUSC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg12143784 chr7:64541923 NA 0.39 6.01 0.31 4.99e-9 Calcium levels; LUSC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg10802521 chr3:52805072 NEK4 -0.54 -8.89 -0.44 3.84e-17 Bipolar disorder; LUSC cis rs829883 1.000 rs249837 chr12:98876535 A/G cg25150519 chr12:98850993 NA 0.64 10.02 0.48 7.74e-21 Colorectal adenoma (advanced); LUSC trans rs6502050 0.835 rs10163483 chr17:80110396 C/A cg07393940 chr7:158741817 NA 0.36 6.52 0.34 2.56e-10 Life satisfaction; LUSC cis rs7917772 0.582 rs7907417 chr10:104370662 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.67 -11.08 -0.52 1.59e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg07092213 chr7:1199455 ZFAND2A -0.67 -11.0 -0.52 3.25e-24 Longevity;Endometriosis; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg02475777 chr4:1388615 CRIPAK 0.44 6.5 0.34 2.92e-10 Obesity-related traits; LUSC cis rs11250098 0.574 rs7015168 chr8:10772210 G/C cg27411982 chr8:10470053 RP1L1 -0.45 -6.71 -0.34 8.15e-11 Morning vs. evening chronotype; LUSC cis rs950169 0.840 rs4842854 chr15:84942339 T/G cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs72781680 0.898 rs6545127 chr2:24060670 C/T cg08917208 chr2:24149416 ATAD2B 0.88 9.86 0.47 2.7e-20 Lymphocyte counts; LUSC cis rs7954584 0.583 rs6486782 chr12:122359172 T/C cg01765077 chr12:122356316 WDR66 0.49 6.73 0.35 7.26e-11 Mean corpuscular volume; LUSC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.71e-13 Bipolar disorder; LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg14844989 chr11:31128820 NA -0.37 -5.79 -0.3 1.67e-8 Red blood cell count; LUSC cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg13256891 chr4:100009986 ADH5 0.48 7.12 0.36 6.62e-12 Alcohol dependence; LUSC trans rs7824557 0.767 rs2164273 chr8:11168499 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.74 0.35 7.02e-11 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg07677032 chr17:61819896 STRADA -0.51 -8.6 -0.43 3.08e-16 Prudent dietary pattern; LUSC cis rs11098499 0.908 rs2017057 chr4:120257711 A/G cg09307838 chr4:120376055 NA 0.8 11.87 0.54 2.4e-27 Corneal astigmatism; LUSC cis rs11792861 0.589 rs75742991 chr9:111929624 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.55 7.84 0.39 6.1e-14 Menarche (age at onset); LUSC cis rs17270561 0.609 rs1317817 chr6:25765377 G/A cg16482183 chr6:26056742 HIST1H1C 0.62 8.37 0.42 1.55e-15 Iron status biomarkers; LUSC cis rs6942756 1.000 rs68076553 chr7:128959632 A/G cg02491457 chr7:128862824 NA -0.48 -6.51 -0.34 2.75e-10 White matter hyperintensity burden; LUSC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.05 0.31 3.83e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg23985595 chr17:80112537 CCDC57 -0.3 -5.69 -0.3 2.77e-8 Life satisfaction; LUSC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg08508325 chr11:3079039 CARS -0.43 -10.6 -0.5 8.3e-23 Longevity; LUSC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg04800585 chr6:26043546 HIST1H2BB 0.43 6.12 0.32 2.56e-9 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg10360139 chr7:1886902 MAD1L1 -0.39 -5.86 -0.31 1.09e-8 Bipolar disorder and schizophrenia; LUSC cis rs7208859 0.623 rs55814012 chr17:29077697 T/A cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4969178 0.965 rs8071884 chr17:76398058 C/G cg05887092 chr17:76393375 PGS1 0.52 8.99 0.44 1.85e-17 HDL cholesterol levels; LUSC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg03388025 chr16:89894329 SPIRE2 0.36 7.61 0.38 2.91e-13 Vitiligo; LUSC cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.32 0.33 8.34e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9296092 0.517 rs56069946 chr6:33511136 G/A cg13560919 chr6:33536144 NA -0.85 -15.07 -0.64 1.59e-39 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -8.35 -0.42 1.87e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg15691649 chr6:25882328 NA 0.51 7.58 0.38 3.4e-13 Blood metabolite levels; LUSC cis rs965513 0.965 rs10759944 chr9:100556972 A/G cg13688889 chr9:100608707 NA -0.54 -8.16 -0.41 6.68e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs7927771 0.864 rs10838724 chr11:47527052 G/T cg18512352 chr11:47633146 NA -0.44 -8.97 -0.44 2.1e-17 Subjective well-being; LUSC trans rs7951870 0.673 rs13448 chr11:46695414 T/C cg04198581 chr6:146289477 NA 0.31 6.08 0.32 3.34e-9 Schizophrenia; LUSC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg15369054 chr17:80825471 TBCD -0.42 -6.85 -0.35 3.49e-11 Breast cancer; LUSC trans rs12439619 1.000 rs35152457 chr15:82546548 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.52 -8.14 -0.41 7.89e-15 Intelligence (multi-trait analysis); LUSC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg12826209 chr6:26865740 GUSBL1 0.75 9.08 0.45 9.54e-18 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05191825 chr12:108956318 ISCU;SART3 0.69 5.98 0.31 5.81e-9 Cognitive performance; LUSC cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg23992470 chr4:843637 GAK -0.55 -6.42 -0.33 4.63e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg11644478 chr21:40555479 PSMG1 0.91 16.83 0.68 1.84e-46 Cognitive function; LUSC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg17143192 chr8:8559678 CLDN23 0.66 9.61 0.47 1.84e-19 Obesity-related traits; LUSC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.36 -5.8 -0.3 1.56e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.9 -0.31 8.73e-9 Platelet count; LUSC cis rs6582630 0.539 rs12308081 chr12:38342881 C/G cg26384229 chr12:38710491 ALG10B -0.52 -7.65 -0.39 2.11e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg11530693 chr1:120165357 ZNF697 0.67 10.55 0.5 1.18e-22 Systemic lupus erythematosus; LUSC cis rs1595825 0.891 rs112898725 chr2:198650006 C/T cg00982548 chr2:198649783 BOLL -0.59 -7.38 -0.37 1.3e-12 Ulcerative colitis; LUSC cis rs11785400 1.000 rs3802232 chr8:143746701 A/G cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg03709012 chr19:19516395 GATAD2A -0.87 -14.56 -0.62 1.56e-37 Tonsillectomy; LUSC cis rs11690935 1.000 rs12053003 chr2:172537350 A/C cg13550731 chr2:172543902 DYNC1I2 0.89 14.74 0.63 3.23e-38 Schizophrenia; LUSC cis rs2439831 0.850 rs3825783 chr15:44102309 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.78 7.05 0.36 1.04e-11 Lung cancer in ever smokers; LUSC cis rs16866061 1.000 rs11688397 chr2:225393173 C/T cg12698349 chr2:225449008 CUL3 0.85 13.71 0.6 3.13e-34 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs1577917 1.000 rs1995688 chr6:86632319 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.33 -0.33 8.06e-10 Response to antipsychotic treatment; LUSC cis rs5758659 0.569 rs133294 chr22:42382805 C/T cg04733989 chr22:42467013 NAGA 0.38 6.27 0.32 1.1e-9 Cognitive function; LUSC cis rs9611565 0.506 rs1984839 chr22:41685937 G/C cg03806693 chr22:41940476 POLR3H -0.6 -8.87 -0.44 4.55e-17 Vitiligo; LUSC cis rs1559088 0.948 rs10408093 chr19:33597816 T/C cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.38e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12020437 chr14:77924595 C14orf133;AHSA1 0.46 6.29 0.33 9.92e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg23711669 chr6:146136114 FBXO30 -0.73 -12.76 -0.57 1.19e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs7538876 0.903 rs1324367 chr1:17752451 C/G cg07965774 chr1:17746286 RCC2 0.32 6.02 0.31 4.57e-9 Basal cell carcinoma; LUSC cis rs77686669 1 rs77686669 chr7:99744572 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.47 6.32 0.33 8.2e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg03233332 chr7:66118400 NA -0.43 -6.18 -0.32 1.85e-9 Aortic root size; LUSC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg08270630 chr22:50330655 NA -0.43 -6.48 -0.33 3.36e-10 Schizophrenia; LUSC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.83 -10.92 -0.51 6.32e-24 Schizophrenia; LUSC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg06636001 chr8:8085503 FLJ10661 0.49 7.16 0.36 5.01e-12 Triglycerides; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs2439831 1.000 rs2584726 chr15:43715382 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.03 0.44 1.37e-17 Lung cancer in ever smokers; LUSC cis rs3808502 0.549 rs4841564 chr8:11425809 T/G cg27411982 chr8:10470053 RP1L1 -0.45 -6.92 -0.35 2.25e-11 Neuroticism; LUSC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg00334542 chr7:100209784 MOSPD3 -0.6 -7.02 -0.36 1.23e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.78 0.39 8.95e-14 Electroencephalogram traits; LUSC cis rs7246657 0.943 rs8106839 chr19:37958475 C/G cg23950597 chr19:37808831 NA -0.62 -7.3 -0.37 2.09e-12 Coronary artery calcification; LUSC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg07701084 chr6:150067640 NUP43 0.47 6.91 0.35 2.41e-11 Lung cancer; LUSC cis rs3125734 0.633 rs3852412 chr10:64050288 C/T cg19640130 chr10:64028056 RTKN2 -0.38 -6.63 -0.34 1.35e-10 Rheumatoid arthritis; LUSC cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg00631329 chr6:26305371 NA -0.45 -8.62 -0.43 2.78e-16 Educational attainment; LUSC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg14019146 chr3:50243930 SLC38A3 -0.32 -7.15 -0.36 5.6e-12 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.11 0.55 3.12e-28 Prudent dietary pattern; LUSC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg06713675 chr4:122721982 EXOSC9 -0.72 -12.31 -0.56 5.85e-29 Type 2 diabetes; LUSC cis rs791888 0.767 rs2255684 chr10:89419971 C/T cg13926569 chr10:89418898 PAPSS2 -0.36 -6.96 -0.36 1.79e-11 Magnesium levels; LUSC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg06074448 chr4:187884817 NA 0.41 6.87 0.35 3.15e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9650657 0.615 rs2271355 chr8:10692158 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.19 -0.32 1.8e-9 Neuroticism; LUSC trans rs941408 1.000 rs1640273 chr19:2803227 C/T cg22153745 chr1:153894579 GATAD2B -0.58 -9.12 -0.45 7.35e-18 Total cholesterol levels; LUSC cis rs3750965 1.000 rs1466222 chr11:68832848 G/A cg06818126 chr11:68850279 TPCN2 -0.44 -6.29 -0.33 9.88e-10 Hair color; LUSC cis rs921665 0.748 rs1869419 chr2:3202080 C/T cg16434511 chr2:3151078 NA -0.58 -5.93 -0.31 7.76e-9 World class endurance athleticism; LUSC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg21963583 chr11:68658836 MRPL21 0.57 8.67 0.43 1.9e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26221243 chr8:128747973 MYC -0.45 -5.98 -0.31 5.84e-9 Hepatitis; LUSC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg14552801 chr7:65878734 NA 0.37 5.78 0.3 1.75e-8 Aortic root size; LUSC cis rs6582630 0.638 rs12831496 chr12:38552604 G/A cg26384229 chr12:38710491 ALG10B -0.54 -8.2 -0.41 5.2e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs7246967 0.611 rs34806882 chr19:22880104 T/C cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs7582180 1.000 rs7588623 chr2:100913361 A/G cg08017756 chr2:100939284 LONRF2 -0.35 -5.85 -0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg08975724 chr8:8085496 FLJ10661 0.48 7.02 0.36 1.24e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs61931739 0.500 rs7971957 chr12:34477558 C/T cg13010199 chr12:38710504 ALG10B 0.58 9.31 0.45 1.79e-18 Morning vs. evening chronotype; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg05950485 chr8:101733214 PABPC1 0.41 6.15 0.32 2.27e-9 Schizophrenia; LUSC cis rs950169 0.724 rs11632668 chr15:84948687 T/C cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs34779708 0.966 rs12762493 chr10:35471873 G/A cg04310649 chr10:35416472 CREM -0.4 -6.22 -0.32 1.53e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7923609 0.812 rs10822184 chr10:65337153 C/T cg01631684 chr10:65280961 REEP3 0.39 6.18 0.32 1.9e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs807669 0.868 rs762529 chr22:19170205 C/G cg02655711 chr22:19163373 SLC25A1 0.9 17.93 0.7 7.5400000000000006e-51 Metabolite levels; LUSC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg21285383 chr16:89894308 SPIRE2 0.36 7.78 0.39 9.1e-14 Vitiligo; LUSC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.81 12.1 0.55 3.33e-28 Cognitive test performance; LUSC cis rs12530845 0.623 rs7798256 chr7:135344211 C/A cg23117316 chr7:135346802 PL-5283 -0.65 -9.81 -0.47 4.03e-20 Red blood cell traits; LUSC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg13206674 chr6:150067644 NUP43 0.5 7.53 0.38 4.76e-13 Lung cancer; LUSC trans rs3857536 0.776 rs9363560 chr6:66949686 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs1440410 0.835 rs4594668 chr4:144050446 A/T cg01719995 chr4:144104893 USP38 -0.32 -5.68 -0.3 2.9e-8 Ischemic stroke; LUSC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg03060546 chr3:49711283 APEH -0.51 -6.98 -0.36 1.6e-11 Menarche (age at onset); LUSC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11644478 chr21:40555479 PSMG1 0.93 18.05 0.7 2.67e-51 Cognitive function; LUSC cis rs66716358 0.744 rs1869480 chr11:44319657 C/G cg16977035 chr11:44330474 ALX4 -0.35 -5.94 -0.31 7.27e-9 Monobrow; LUSC cis rs2404602 0.692 rs7174673 chr15:77071998 T/C cg22467129 chr15:76604101 ETFA -0.44 -6.99 -0.36 1.47e-11 Blood metabolite levels; LUSC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg12365402 chr11:9010492 NRIP3 -0.51 -9.81 -0.47 4.04e-20 Hemoglobin concentration; LUSC cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg14416269 chr4:6271139 WFS1 0.44 8.25 0.41 3.82e-15 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1577917 0.958 rs12202188 chr6:86562700 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs9326248 0.581 rs12225187 chr11:116793231 G/A cg01368799 chr11:117014884 PAFAH1B2 0.57 8.71 0.43 1.41e-16 Blood protein levels; LUSC cis rs6754311 0.550 rs3213889 chr2:136511575 A/G cg07169764 chr2:136633963 MCM6 -0.59 -7.85 -0.39 5.75e-14 Mosquito bite size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18416022 chr19:58089961 ZNF416 -0.41 -6.17 -0.32 1.93e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs317689 0.513 rs529268 chr12:69687051 G/A cg20891283 chr12:69753455 YEATS4 0.61 9.8 0.47 4.24e-20 Response to diuretic therapy; LUSC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg22834771 chr12:69754056 YEATS4 -0.56 -8.42 -0.42 1.11e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs1799949 0.965 rs8071278 chr17:41193910 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.51 8.51 0.42 6.1e-16 Menopause (age at onset); LUSC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg21699342 chr2:239360505 ASB1 0.56 10.33 0.49 6.79e-22 Multiple system atrophy; LUSC cis rs713587 0.719 rs4665736 chr2:25187599 C/T cg15423357 chr2:25149977 NA -0.37 -7.29 -0.37 2.3e-12 Body mass index in non-asthmatics; LUSC cis rs10435719 0.580 rs13260712 chr8:11782570 A/C cg21775007 chr8:11205619 TDH -0.41 -5.79 -0.3 1.62e-8 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs3755132 0.929 rs7579604 chr2:15746975 A/T cg12888861 chr2:15731646 DDX1 0.5 7.27 0.37 2.55e-12 Wilms tumor; LUSC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg05855489 chr10:104503620 C10orf26 -0.62 -7.62 -0.38 2.59e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs59104589 0.617 rs3771567 chr2:242358619 G/A cg14842376 chr2:242211374 HDLBP 0.51 5.92 0.31 8e-9 Fibrinogen levels; LUSC cis rs7927771 0.524 rs10838732 chr11:47607940 C/G cg20307385 chr11:47447363 PSMC3 0.44 6.43 0.33 4.53e-10 Subjective well-being; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21728825 chr2:128568322 WDR33 0.39 6.11 0.32 2.79e-9 Triglycerides; LUSC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg09904177 chr6:26538194 HMGN4 -0.39 -5.69 -0.3 2.76e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs3771570 1.000 rs62186400 chr2:242226700 A/G cg21155796 chr2:242212141 HDLBP 0.68 7.51 0.38 5.46e-13 Prostate cancer; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.97 0.44 2.22e-17 Prudent dietary pattern; LUSC cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg23029597 chr12:123009494 RSRC2 -0.7 -9.67 -0.47 1.18e-19 Body mass index; LUSC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11890956 chr21:40555474 PSMG1 0.73 11.98 0.55 9.43e-28 Cognitive function; LUSC cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg04455712 chr21:45112962 RRP1B 0.46 8.75 0.43 1.07e-16 Mean corpuscular volume; LUSC cis rs17818399 1.000 rs62136864 chr2:46829124 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.47 -6.34 -0.33 7.64e-10 Height; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg06873352 chr17:61820015 STRADA -0.59 -10.07 -0.48 5.37e-21 Prudent dietary pattern; LUSC cis rs4786125 0.573 rs7201500 chr16:6897659 A/G cg03623568 chr16:6915990 A2BP1 -0.36 -6.36 -0.33 6.52e-10 Heart rate variability traits (SDNN); LUSC cis rs10782582 0.609 rs5745325 chr1:76269460 G/A cg03433033 chr1:76189801 ACADM -0.43 -6.35 -0.33 7.05e-10 Daytime sleep phenotypes; LUSC cis rs3087591 0.920 rs2905881 chr17:29547862 T/C cg24425628 chr17:29625626 OMG;NF1 0.56 8.28 0.41 3.07e-15 Hip circumference; LUSC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg01416388 chr22:39784598 NA -0.42 -6.94 -0.35 2.11e-11 Intelligence (multi-trait analysis); LUSC cis rs9612 1.000 rs16976747 chr19:44238152 G/A cg08581076 chr19:44259116 C19orf61 0.52 6.32 0.33 8.18e-10 Exhaled nitric oxide output; LUSC trans rs7824557 0.767 rs7837036 chr8:11175489 A/G cg15556689 chr8:8085844 FLJ10661 0.56 8.78 0.43 8.62e-17 Retinal vascular caliber; LUSC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg12292205 chr6:26970375 C6orf41 -0.69 -12.16 -0.55 2.12e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs950169 0.580 rs4603535 chr15:85173872 C/T cg17173187 chr15:85201210 NMB 0.49 9.32 0.45 1.67e-18 Schizophrenia; LUSC cis rs9640161 0.830 rs17173702 chr7:150068605 G/A cg21361702 chr7:150065534 REPIN1 0.57 8.0 0.4 2.14e-14 Blood protein levels;Circulating chemerin levels; LUSC trans rs2204008 0.604 rs2320521 chr12:38253789 A/G cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.74e-9 Bladder cancer; LUSC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg08847533 chr14:75593920 NEK9 0.85 15.68 0.65 6.62e-42 Height; LUSC trans rs911555 0.723 rs6575991 chr14:103908433 C/T cg17675199 chr6:35436792 RPL10A -0.4 -5.95 -0.31 6.75e-9 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.57 -8.64 -0.43 2.28e-16 Menarche (age at onset); LUSC cis rs7582720 0.943 rs72934550 chr2:203983940 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.61 0.43 2.86e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs72960926 0.744 rs72967284 chr6:75024375 C/T cg03266952 chr6:74778945 NA -0.82 -7.01 -0.36 1.29e-11 Metabolite levels (MHPG); LUSC cis rs1994135 0.608 rs1482994 chr12:33713631 T/C cg06521331 chr12:34319734 NA -0.4 -5.69 -0.3 2.76e-8 Resting heart rate; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24357026 chr19:36705589 ZNF565;ZNF146 -0.41 -6.37 -0.33 6.34e-10 Electrocardiographic conduction measures; LUSC cis rs9527 0.615 rs36045108 chr10:104697929 G/A cg05855489 chr10:104503620 C10orf26 0.53 8.19 0.41 5.43e-15 Arsenic metabolism; LUSC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2033711 0.654 rs734380 chr19:58898963 A/C cg00825309 chr19:58991885 ZNF446 -0.41 -6.11 -0.32 2.77e-9 Uric acid clearance; LUSC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.24 0.52 4.42e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.735 rs2957614 chr15:76696635 C/T cg23625390 chr15:77176239 SCAPER 0.62 9.75 0.47 6.47e-20 Blood metabolite levels; LUSC trans rs61931739 0.635 rs6488185 chr12:33933127 G/C cg26384229 chr12:38710491 ALG10B 0.51 7.63 0.39 2.51e-13 Morning vs. evening chronotype; LUSC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg13531842 chr10:38383804 ZNF37A -0.44 -6.69 -0.34 9.63e-11 Extrinsic epigenetic age acceleration; LUSC cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg03146154 chr1:46216737 IPP -0.51 -7.46 -0.38 7.41e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs77741769 0.591 rs73413868 chr12:121301732 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.64 0.43 2.42e-16 Mean corpuscular volume; LUSC cis rs4974559 0.947 rs7659916 chr4:1361013 C/T cg02980000 chr4:1222292 CTBP1 0.72 6.75 0.35 6.52e-11 Systolic blood pressure; LUSC trans rs7618501 0.633 rs6792892 chr3:49995518 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.59 9.47 0.46 5.4e-19 Intelligence (multi-trait analysis); LUSC trans rs9929218 0.954 rs60302411 chr16:68824220 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.09 -0.52 1.52e-24 Colorectal cancer; LUSC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg22800045 chr5:56110881 MAP3K1 -0.52 -7.56 -0.38 4.01e-13 Initial pursuit acceleration; LUSC cis rs11676348 0.935 rs4674250 chr2:218977531 G/A cg00012203 chr2:219082015 ARPC2 -0.54 -8.47 -0.42 8.15e-16 Ulcerative colitis; LUSC cis rs4077468 1.000 rs9661504 chr1:205915667 A/T cg07167872 chr1:205819463 PM20D1 -0.39 -5.78 -0.3 1.7e-8 Cystic fibrosis-related diabetes; LUSC cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg26384229 chr12:38710491 ALG10B 0.93 17.52 0.69 3.28e-49 Heart rate; LUSC cis rs7712401 0.584 rs28373879 chr5:122372402 G/C cg19077854 chr5:122220652 SNX24 0.36 7.32 0.37 1.81e-12 Mean platelet volume; LUSC cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg17173187 chr15:85201210 NMB 0.48 9.21 0.45 3.74e-18 Schizophrenia; LUSC cis rs7258465 0.965 rs1560118 chr19:18570035 G/A cg06462663 chr19:18546047 ISYNA1 0.47 7.81 0.39 7.61e-14 Breast cancer; LUSC cis rs8016982 0.962 rs8007841 chr14:81647878 C/T cg01989461 chr14:81687754 GTF2A1 -0.45 -6.64 -0.34 1.26e-10 Schizophrenia; LUSC trans rs561341 1.000 rs555629 chr17:30294136 T/C cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs8017423 0.935 rs59179255 chr14:90691773 A/C cg04374321 chr14:90722782 PSMC1 0.71 11.25 0.52 3.96e-25 Mortality in heart failure; LUSC cis rs1256061 0.603 rs1256045 chr14:64729760 A/C cg23250157 chr14:64679961 SYNE2 0.32 5.7 0.3 2.68e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg06481639 chr22:41940642 POLR3H 0.48 5.8 0.3 1.57e-8 Vitiligo; LUSC cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg26384229 chr12:38710491 ALG10B 0.91 17.02 0.68 3.17e-47 Heart rate; LUSC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg10018233 chr7:150070692 REPIN1 0.39 6.74 0.35 6.82e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs9527 0.830 rs12249194 chr10:104643698 T/C cg04362960 chr10:104952993 NT5C2 0.64 9.38 0.46 1.02e-18 Arsenic metabolism; LUSC cis rs5769707 0.872 rs5770604 chr22:50030672 G/A cg05373962 chr22:49881684 NA -0.42 -10.05 -0.48 6.2e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9467711 0.659 rs66941101 chr6:26530376 C/T cg09904177 chr6:26538194 HMGN4 -0.79 -6.14 -0.32 2.29e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg12311346 chr5:56204834 C5orf35 -0.99 -14.41 -0.62 5.84e-37 Initial pursuit acceleration; LUSC cis rs8058578 0.775 rs8046391 chr16:30836648 G/C cg02466173 chr16:30829666 NA -0.58 -10.78 -0.51 1.9e-23 Multiple myeloma; LUSC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg07716408 chr11:68623521 NA -0.32 -6.13 -0.32 2.48e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9549260 0.709 rs9549247 chr13:41220777 G/C cg21288729 chr13:41239152 FOXO1 0.65 10.06 0.48 5.76e-21 Red blood cell count; LUSC cis rs9311676 0.632 rs62258139 chr3:58406836 C/T cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.3e-10 Systemic lupus erythematosus; LUSC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg11301795 chr4:187892539 NA -0.85 -16.73 -0.68 4.42e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs8040855 0.627 rs2304418 chr15:85640983 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -5.81 -0.3 1.45e-8 Bulimia nervosa; LUSC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg06221963 chr1:154839813 KCNN3 0.5 10.3 0.49 8.58e-22 Prostate cancer; LUSC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg17554472 chr22:41940697 POLR3H -0.48 -5.94 -0.31 7.14e-9 Vitiligo; LUSC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg06454157 chr6:167490870 NA -0.23 -5.76 -0.3 1.87e-8 Crohn's disease; LUSC cis rs427941 0.632 rs201522 chr7:101771546 C/T cg06246474 chr7:101738831 CUX1 0.37 6.21 0.32 1.59e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs6066835 1.000 rs6066837 chr20:47357337 A/C cg18078177 chr20:47281410 PREX1 0.75 6.44 0.33 4.14e-10 Multiple myeloma; LUSC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg26380479 chr7:97908229 NA -0.26 -5.77 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs1005277 0.505 rs719569 chr10:38154415 T/G cg17830980 chr10:43048298 ZNF37B 0.42 6.51 0.34 2.72e-10 Extrinsic epigenetic age acceleration; LUSC trans rs72674100 1.000 rs28368230 chr4:97970611 G/A cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2282300 0.637 rs7942037 chr11:30430332 G/C cg25418670 chr11:30344373 C11orf46 -0.4 -6.29 -0.33 1.01e-9 Morning vs. evening chronotype; LUSC cis rs1448094 0.967 rs2121892 chr12:86324556 G/T cg00310523 chr12:86230176 RASSF9 0.4 7.18 0.37 4.67e-12 Major depressive disorder; LUSC cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg08085267 chr17:45401833 C17orf57 -0.51 -7.31 -0.37 2.02e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1003719 0.715 rs1981432 chr21:38541356 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC cis rs870825 0.616 rs7692367 chr4:185651056 T/C cg04058563 chr4:185651563 MLF1IP 0.82 12.42 0.56 2.15e-29 Blood protein levels; LUSC trans rs931812 0.964 rs2102290 chr8:101919844 G/C cg20993868 chr7:22813445 NA 0.59 10.82 0.51 1.36e-23 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg10729496 chr3:10149963 C3orf24 0.59 7.62 0.38 2.67e-13 Alzheimer's disease; LUSC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg25072359 chr17:41440525 NA 0.6 7.8 0.39 7.91e-14 Menopause (age at onset); LUSC cis rs4951018 0.853 rs1573104 chr1:205636907 A/C cg11965913 chr1:205819406 PM20D1 -0.42 -6.39 -0.33 5.72e-10 Prostate-specific antigen levels; LUSC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg22529645 chr1:3704559 LRRC47 0.33 5.72 0.3 2.32e-8 Red cell distribution width; LUSC cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg13535736 chr9:111863775 C9orf5 -0.37 -5.9 -0.31 8.82e-9 Menarche (age at onset); LUSC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg26695010 chr11:65641043 EFEMP2 -0.47 -7.09 -0.36 7.82e-12 Eosinophil percentage of white cells; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg09877947 chr5:131593287 PDLIM4 -0.55 -8.5 -0.42 6.28e-16 Acylcarnitine levels; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg00024416 chr22:24240387 NA -0.34 -6.04 -0.31 4.03e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7584330 0.666 rs937386 chr2:238364039 C/T cg14458575 chr2:238380390 NA 0.86 15.19 0.64 5.38e-40 Prostate cancer; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.28 -7.29 -0.37 2.21e-12 Lymphocyte counts; LUSC cis rs12940923 1.000 rs11867689 chr17:56370355 G/C cg19466818 chr17:56409534 MIR142 -0.38 -6.76 -0.35 6.25e-11 Circulating myeloperoxidase levels (plasma); LUSC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg12463550 chr7:65579703 CRCP -0.51 -7.33 -0.37 1.74e-12 Aortic root size; LUSC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg21643547 chr1:205240462 TMCC2 -0.5 -9.3 -0.45 1.95e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs17270561 0.666 rs9356988 chr6:25777481 G/A cg16482183 chr6:26056742 HIST1H1C 0.59 8.2 0.41 5.31e-15 Iron status biomarkers; LUSC trans rs7939886 0.841 rs79902631 chr11:55995241 A/C cg03929089 chr4:120376271 NA 0.82 6.13 0.32 2.55e-9 Myopia (pathological); LUSC cis rs1808579 0.874 rs1788817 chr18:21097460 A/G cg14672496 chr18:21087552 C18orf8 0.39 6.97 0.36 1.69e-11 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg05890377 chr2:74357713 NA 0.74 13.68 0.6 3.91e-34 Gestational age at birth (maternal effect); LUSC cis rs6076065 0.723 rs1419009 chr20:23365094 G/A cg11657817 chr20:23433608 CST11 0.43 8.07 0.4 1.25e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs473651 0.935 rs508483 chr2:239339709 T/C cg18131467 chr2:239335373 ASB1 1.04 25.8 0.82 1.72e-81 Multiple system atrophy; LUSC trans rs6981523 0.553 rs11989369 chr8:11055385 A/G cg15556689 chr8:8085844 FLJ10661 0.49 6.28 0.32 1.07e-9 Neuroticism; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg06600287 chr1:53387719 ECHDC2 -0.29 -5.7 -0.3 2.59e-8 Monocyte count; LUSC cis rs13006833 0.634 rs1876877 chr2:191145274 G/A cg21644426 chr2:191273491 MFSD6 0.44 6.28 0.33 1.03e-9 Urinary metabolites; LUSC cis rs7953508 0.506 rs10859532 chr12:93960917 G/C cg18151635 chr12:93972918 NA -0.61 -8.85 -0.44 5.17e-17 Pubertal anthropometrics; LUSC cis rs11785400 0.928 rs750529 chr8:143744877 G/C cg24634471 chr8:143751801 JRK 0.59 8.98 0.44 1.97e-17 Schizophrenia; LUSC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg06238570 chr21:40685208 BRWD1 -0.64 -10.79 -0.51 1.73e-23 Cognitive function; LUSC cis rs478304 0.934 rs1193496 chr11:65537556 C/T cg27068330 chr11:65405492 SIPA1 -0.61 -9.25 -0.45 2.78e-18 Acne (severe); LUSC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg26408565 chr15:76604113 ETFA 0.47 7.61 0.38 2.85e-13 Blood metabolite levels; LUSC trans rs61931739 0.534 rs4931770 chr12:34044479 G/T cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 2.92e-25 Morning vs. evening chronotype; LUSC cis rs55882075 0.535 rs67484565 chr5:179110574 G/T cg14593053 chr5:179126677 CANX 0.38 5.96 0.31 6.29e-9 Monocyte percentage of white cells; LUSC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.74 0.35 6.98e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs9888739 0.800 rs1143678 chr16:31343005 C/T cg15817542 chr16:31343056 ITGAM -0.53 -7.13 -0.36 6.08e-12 Systemic lupus erythematosus; LUSC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg18512352 chr11:47633146 NA -0.46 -9.25 -0.45 2.83e-18 Subjective well-being; LUSC cis rs9361491 0.657 rs9343798 chr6:79455282 A/G cg05283184 chr6:79620031 NA -0.32 -5.87 -0.31 1.04e-8 Intelligence (multi-trait analysis); LUSC cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg06026331 chr20:60912101 LAMA5 -0.61 -7.29 -0.37 2.29e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs2204008 0.837 rs2387317 chr12:38235319 T/C cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.38e-9 Bladder cancer; LUSC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg22782873 chr19:19639568 YJEFN3 0.53 6.36 0.33 6.46e-10 Bipolar disorder; LUSC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.17e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg08085267 chr17:45401833 C17orf57 -0.47 -6.66 -0.34 1.11e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg05025164 chr4:1340916 KIAA1530 0.54 8.4 0.42 1.29e-15 Obesity-related traits; LUSC cis rs7666738 0.716 rs6827474 chr4:99089683 T/G cg03676636 chr4:99064102 C4orf37 0.3 6.36 0.33 6.6e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.921 rs10891280 chr11:111433609 A/T cg09085632 chr11:111637200 PPP2R1B 0.95 13.23 0.59 2.02e-32 Primary sclerosing cholangitis; LUSC cis rs7759001 0.817 rs2393929 chr6:27351931 A/C cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 2.04e-8 Glomerular filtration rate (creatinine); LUSC cis rs7246657 0.943 rs10406177 chr19:37907947 G/A cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs10751667 1.000 rs7395632 chr11:958789 C/T ch.11.42038R chr11:967971 AP2A2 -0.49 -7.64 -0.39 2.35e-13 Alzheimer's disease (late onset); LUSC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 -0.42 -5.82 -0.3 1.4e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs713477 0.505 rs8019080 chr14:55891372 C/T cg13175173 chr14:55914753 NA -0.31 -5.94 -0.31 7.31e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs7582180 0.817 rs2309820 chr2:100899676 T/C cg08017756 chr2:100939284 LONRF2 -0.37 -6.23 -0.32 1.41e-9 Intelligence (multi-trait analysis); LUSC trans rs60843830 1.000 rs62114505 chr2:242426 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 10.49 0.5 1.91e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg08392591 chr16:89556376 ANKRD11 0.4 6.01 0.31 4.85e-9 Multiple myeloma (IgH translocation); LUSC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg19318889 chr4:1322082 MAEA 0.45 7.13 0.36 6.31e-12 Obesity-related traits; LUSC cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg00012203 chr2:219082015 ARPC2 -0.89 -16.74 -0.68 4.09e-46 Colorectal cancer; LUSC cis rs7223966 1.000 rs8077265 chr17:61732727 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.18 0.37 4.56e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2067615 0.524 rs9804754 chr12:107083031 G/A cg15890332 chr12:107067104 RFX4 0.36 6.24 0.32 1.35e-9 Heart rate; LUSC cis rs992157 1.000 rs2292553 chr2:219146803 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.54 8.32 0.41 2.32e-15 Colorectal cancer; LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg14668632 chr7:2872130 GNA12 0.41 6.0 0.31 5.02e-9 Height; LUSC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10743315 0.643 rs58663385 chr12:19337070 T/C cg02471346 chr12:19282374 PLEKHA5 0.59 5.81 0.3 1.47e-8 Gut microbiota (bacterial taxa); LUSC cis rs7561273 0.586 rs9309225 chr2:24292863 T/C cg06627628 chr2:24431161 ITSN2 -0.51 -6.83 -0.35 3.93e-11 Quantitative traits; LUSC cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg09796270 chr17:17721594 SREBF1 0.45 7.37 0.37 1.34e-12 Total body bone mineral density; LUSC cis rs6840360 1.000 rs6823002 chr4:152604467 T/G cg22705602 chr4:152727874 NA -0.28 -5.86 -0.31 1.09e-8 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg15316289 chr22:50310904 ALG12;CRELD2 0.47 6.91 0.35 2.45e-11 Schizophrenia; LUSC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg05347473 chr6:146136440 FBXO30 0.58 10.06 0.48 5.49e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.56 1.53e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3099143 1.000 rs4583202 chr15:77161676 G/A cg21673338 chr15:77095150 SCAPER 0.78 7.34 0.37 1.64e-12 Recalcitrant atopic dermatitis; LUSC cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg17971929 chr21:40555470 PSMG1 0.77 13.29 0.59 1.16e-32 Cognitive function; LUSC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs4654899 0.772 rs951805 chr1:21060356 A/G cg01072550 chr1:21505969 NA 0.47 6.96 0.36 1.85e-11 Superior frontal gyrus grey matter volume; LUSC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.49 -0.42 6.77e-16 Total body bone mineral density; LUSC cis rs73206853 0.841 rs28404862 chr12:110850241 C/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg08270630 chr22:50330655 NA -0.43 -6.5 -0.33 2.98e-10 Schizophrenia; LUSC cis rs7247513 0.790 rs17476839 chr19:12762783 C/T cg01871581 chr19:12707946 ZNF490 0.51 7.52 0.38 5.17e-13 Bipolar disorder; LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg03576123 chr11:487126 PTDSS2 -0.91 -10.25 -0.49 1.24e-21 Body mass index; LUSC trans rs11098499 0.954 rs12510138 chr4:120423935 C/G cg25214090 chr10:38739885 LOC399744 0.52 7.55 0.38 4.24e-13 Corneal astigmatism; LUSC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11644478 chr21:40555479 PSMG1 0.96 19.27 0.73 3.81e-56 Cognitive function; LUSC cis rs6693567 0.565 rs834234 chr1:150352494 C/G cg15654264 chr1:150340011 RPRD2 -0.43 -6.81 -0.35 4.48e-11 Migraine; LUSC cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs2742417 0.967 rs2742439 chr3:45744248 G/A cg04837898 chr3:45731254 SACM1L -0.35 -5.66 -0.3 3.28e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs2204008 0.654 rs1733410 chr12:38132172 G/A cg26384229 chr12:38710491 ALG10B -0.68 -10.45 -0.5 2.62e-22 Bladder cancer; LUSC cis rs921968 0.565 rs4674328 chr2:219593203 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.98 -0.48 1.09e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs6809651 0.524 rs12638263 chr3:185795855 A/C cg00760338 chr3:185826511 ETV5 -0.62 -8.92 -0.44 3.16e-17 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; LUSC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC cis rs240764 0.853 rs108422 chr6:101039279 G/C cg09795085 chr6:101329169 ASCC3 0.4 5.76 0.3 1.87e-8 Neuroticism; LUSC cis rs5769707 0.706 rs2071903 chr22:50034517 G/A cg05373962 chr22:49881684 NA -0.4 -8.61 -0.43 2.85e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.18e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6484504 0.532 rs1475558 chr11:31263428 A/G cg06552810 chr11:31128660 NA -0.41 -7.13 -0.36 6.32e-12 Red blood cell count; LUSC cis rs11250098 0.510 rs4840525 chr8:10765635 C/A cg21775007 chr8:11205619 TDH -0.5 -6.81 -0.35 4.68e-11 Morning vs. evening chronotype; LUSC cis rs3809863 0.602 rs6504833 chr17:45396087 A/G cg08085267 chr17:45401833 C17orf57 -0.66 -10.12 -0.48 3.51e-21 Glaucoma (primary open-angle); LUSC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.56 0.42 4.2e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2901656 0.627 rs7528296 chr1:172381383 A/G cg03748243 chr1:172413542 C1orf105;PIGC 0.35 6.74 0.35 7.09e-11 Red cell distribution width;Platelet distribution width; LUSC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg00271210 chr6:167070053 RPS6KA2 -0.28 -5.83 -0.3 1.33e-8 Crohn's disease; LUSC cis rs6762 0.550 rs8672 chr11:838634 C/G cg15787769 chr11:842744 TSPAN4;POLR2L -0.53 -7.24 -0.37 3.2e-12 Mean platelet volume; LUSC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg23630131 chr7:65973040 NA 0.2 5.71 0.3 2.54e-8 Aortic root size; LUSC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg03036452 chr22:46663545 TTC38 0.59 5.95 0.31 6.85e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg01689657 chr7:91764605 CYP51A1 -0.32 -5.77 -0.3 1.79e-8 Breast cancer; LUSC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg16325326 chr1:53192061 ZYG11B 0.96 17.99 0.7 4.36e-51 Monocyte count; LUSC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs1908814 0.516 rs13275143 chr8:11796990 T/A cg06636001 chr8:8085503 FLJ10661 0.53 7.8 0.39 7.95e-14 Neuroticism; LUSC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg08773314 chr2:239334832 ASB1 0.43 9.34 0.46 1.42e-18 Multiple system atrophy; LUSC cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg17892150 chr10:133769511 PPP2R2D -0.64 -9.11 -0.45 7.89e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg11062466 chr8:58055876 NA 0.51 5.81 0.3 1.44e-8 Developmental language disorder (linguistic errors); LUSC cis rs11030122 0.702 rs10835399 chr11:3989182 G/A cg08557956 chr11:4115526 RRM1 -0.46 -5.81 -0.3 1.42e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs11605924 0.934 rs7945565 chr11:45878992 A/G ch.11.939596F chr11:45881766 CRY2 -0.58 -9.07 -0.44 1.02e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg26395211 chr5:140044315 WDR55 -0.4 -6.24 -0.32 1.33e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs9392556 0.829 rs629362 chr6:4121831 A/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.37 -6.62 -0.34 1.44e-10 Blood metabolite levels; LUSC cis rs9473147 0.543 rs4711878 chr6:47456118 A/G cg20196966 chr6:47445060 CD2AP 0.41 5.78 0.3 1.7e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs28374715 0.681 rs59000092 chr15:41626148 A/G cg18705301 chr15:41695430 NDUFAF1 -0.94 -18.67 -0.71 8.71e-54 Ulcerative colitis; LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg02475777 chr4:1388615 CRIPAK -0.58 -8.55 -0.42 4.51e-16 Obesity-related traits; LUSC cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg14829155 chr15:31115871 NA -0.56 -7.67 -0.39 1.85e-13 Huntington's disease progression; LUSC cis rs826838 1.000 rs826888 chr12:39104719 C/G cg26384229 chr12:38710491 ALG10B -0.84 -15.98 -0.66 4.2e-43 Heart rate; LUSC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg08975724 chr8:8085496 FLJ10661 -0.46 -7.06 -0.36 9.99e-12 Neuroticism; LUSC trans rs12200782 0.932 rs12189841 chr6:26544798 A/T cg11837749 chr1:55047332 ACOT11 0.58 6.31 0.33 8.85e-10 Small cell lung carcinoma; LUSC cis rs1371867 0.846 rs1788181 chr8:101334068 C/T cg00191853 chr8:101177733 SPAG1 -0.39 -6.47 -0.33 3.49e-10 Atrioventricular conduction; LUSC cis rs4964805 0.549 rs1976256 chr12:104156899 G/C cg02344784 chr12:104178138 NT5DC3 0.41 6.47 0.33 3.42e-10 Attention deficit hyperactivity disorder; LUSC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg10253484 chr15:75165896 SCAMP2 -0.44 -6.26 -0.32 1.21e-9 Breast cancer; LUSC cis rs11191270 0.554 rs11191265 chr10:104102118 G/A cg15320455 chr10:103880129 LDB1 0.58 5.97 0.31 6.12e-9 Intelligence (multi-trait analysis); LUSC cis rs1941023 0.568 rs1373064 chr11:60168200 C/T cg08716584 chr11:60157161 MS4A7 -0.62 -11.34 -0.53 1.9e-25 Congenital heart disease (maternal effect); LUSC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 10.76 0.51 2.3e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg00933542 chr6:150070202 PCMT1 0.34 7.03 0.36 1.14e-11 Lung cancer; LUSC cis rs72781680 0.652 rs12618900 chr2:23910775 C/T cg08917208 chr2:24149416 ATAD2B 1.0 9.65 0.47 1.39e-19 Lymphocyte counts; LUSC cis rs9660992 0.542 rs17345153 chr1:205179997 A/G cg21643547 chr1:205240462 TMCC2 -0.44 -8.01 -0.4 1.87e-14 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg23791538 chr6:167370224 RNASET2 -0.37 -5.87 -0.31 1.05e-8 Crohn's disease; LUSC cis rs56146971 0.763 rs11160005 chr14:91872587 G/C cg10511902 chr14:91842949 CCDC88C 0.44 5.69 0.3 2.74e-8 Alzheimer disease and age of onset; LUSC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34375054 0.660 rs12578446 chr12:125605887 A/G cg06287003 chr12:125626642 AACS -0.41 -6.87 -0.35 3.1e-11 Post bronchodilator FEV1/FVC ratio; LUSC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg03929089 chr4:120376271 NA -0.95 -15.16 -0.64 7.47e-40 Coronary artery disease; LUSC cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.73 10.46 0.5 2.42e-22 Response to bleomycin (chromatid breaks); LUSC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg21963583 chr11:68658836 MRPL21 0.54 8.24 0.41 4e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6546550 0.900 rs897122 chr2:70140271 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.59 -5.66 -0.3 3.2e-8 Cerebrospinal P-tau181p levels; LUSC cis rs7267979 1.000 rs6050561 chr20:25334855 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.56 -0.34 2.06e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg13736514 chr6:26305472 NA -0.45 -8.94 -0.44 2.72e-17 Educational attainment; LUSC cis rs2292864 0.764 rs1969269 chr17:45335537 C/A cg18085866 chr17:45331354 ITGB3 -0.71 -6.07 -0.32 3.46e-9 Left atrial antero-posterior diameter; LUSC cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg09035930 chr12:129282057 SLC15A4 0.73 15.47 0.65 4.48e-41 Systemic lupus erythematosus; LUSC cis rs68170813 0.559 rs12535081 chr7:106979291 C/T cg02696742 chr7:106810147 HBP1 -0.66 -9.77 -0.47 5.56e-20 Coronary artery disease; LUSC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg22968622 chr17:43663579 NA 0.8 12.38 0.56 3.25e-29 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg05082376 chr22:42548792 NA -0.43 -6.87 -0.35 3.23e-11 Schizophrenia; LUSC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg18404041 chr3:52824283 ITIH1 -0.47 -8.84 -0.44 5.48e-17 Bipolar disorder; LUSC cis rs13315871 1.000 rs11710058 chr3:58383048 G/A cg12435725 chr3:58293450 RPP14 -0.73 -7.19 -0.37 4.4e-12 Cholesterol, total; LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg03909863 chr11:638404 DRD4 -0.41 -6.19 -0.32 1.81e-9 Systemic lupus erythematosus; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg08888203 chr3:10149979 C3orf24 0.59 8.1 0.41 1.08e-14 Alzheimer's disease; LUSC trans rs61931739 0.517 rs1486882 chr12:34025896 A/G cg26384229 chr12:38710491 ALG10B 0.72 11.31 0.53 2.59e-25 Morning vs. evening chronotype; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg11494091 chr17:61959527 GH2 0.63 13.39 0.59 4.87e-33 Prudent dietary pattern; LUSC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg07701084 chr6:150067640 NUP43 0.57 8.96 0.44 2.41e-17 Lung cancer; LUSC cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.67 -0.3 3.01e-8 Extrinsic epigenetic age acceleration; LUSC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg00033643 chr7:134001901 SLC35B4 0.45 7.05 0.36 1.02e-11 Mean platelet volume; LUSC trans rs7824557 0.767 rs6985460 chr8:11171087 A/C cg08975724 chr8:8085496 FLJ10661 0.47 6.85 0.35 3.59e-11 Retinal vascular caliber; LUSC cis rs4654899 0.680 rs12407731 chr1:21254789 C/T cg01072550 chr1:21505969 NA -0.54 -8.08 -0.4 1.21e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.65 10.85 0.51 1.07e-23 Systemic lupus erythematosus; LUSC trans rs9329221 0.619 rs591346 chr8:9818065 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.05 -0.4 1.42e-14 Neuroticism; LUSC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.67 0.34 1.07e-10 Menopause (age at onset); LUSC cis rs6674970 0.933 rs11204772 chr1:151056305 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.46 -6.14 -0.32 2.4e-9 Childhood ear infection; LUSC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg17971929 chr21:40555470 PSMG1 0.68 11.44 0.53 8.42e-26 Cognitive function; LUSC trans rs7618501 0.602 rs2240326 chr3:50128386 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.59 -0.46 2.08e-19 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs7184144 chr16:48606077 C/T cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.47e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg26597838 chr10:835615 NA 1.22 16.56 0.67 2.15e-45 Eosinophil percentage of granulocytes; LUSC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg19318889 chr4:1322082 MAEA 0.47 7.8 0.39 8.25e-14 Obesity-related traits; LUSC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg07167872 chr1:205819463 PM20D1 0.52 7.94 0.4 3.11e-14 Prostate-specific antigen levels; LUSC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg22535103 chr8:58192502 C8orf71 -0.82 -10.08 -0.48 4.74e-21 Developmental language disorder (linguistic errors); LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg22963979 chr7:1858916 MAD1L1 -0.73 -12.55 -0.57 7.22e-30 Bipolar disorder and schizophrenia; LUSC cis rs77106637 0.858 rs117819392 chr11:72514503 C/T cg04827223 chr11:72435913 ARAP1 -0.73 -9.23 -0.45 3.17e-18 Type 2 diabetes; LUSC cis rs4803468 1.000 rs11670668 chr19:41920454 G/C cg09537434 chr19:41945824 ATP5SL -0.92 -15.94 -0.66 6.34e-43 Height; LUSC cis rs7605827 0.860 rs6760297 chr2:15632472 T/C cg19274914 chr2:15703543 NA 0.47 9.15 0.45 5.75e-18 Educational attainment (years of education); LUSC cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.6 -0.38 3.03e-13 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg25456477 chr12:86230367 RASSF9 0.38 6.83 0.35 4.07e-11 Major depressive disorder; LUSC cis rs926938 0.563 rs360642 chr1:115425429 C/G cg12756093 chr1:115239321 AMPD1 0.4 5.89 0.31 9.21e-9 Autism; LUSC cis rs4808199 0.948 rs757000 chr19:19448301 A/G cg03709012 chr19:19516395 GATAD2A 0.99 12.02 0.55 6.89e-28 Nonalcoholic fatty liver disease; LUSC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.67 11.52 0.53 4.54e-26 Menarche (age at onset); LUSC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg05623727 chr3:50126028 RBM5 0.32 5.92 0.31 7.9e-9 Intelligence (multi-trait analysis); LUSC cis rs8058578 0.945 rs885107 chr16:30672719 T/C cg02466173 chr16:30829666 NA -0.59 -10.69 -0.5 3.88e-23 Multiple myeloma; LUSC cis rs7223966 0.960 rs11659013 chr17:61869559 C/G cg00945038 chr17:61921165 SMARCD2 0.39 5.99 0.31 5.57e-9 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09649245 chr11:44332195 ALX4 0.38 6.01 0.31 4.99e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9419702 0.538 rs9419625 chr10:133534954 T/G cg04492858 chr10:133558786 NA 0.44 7.17 0.37 4.96e-12 Survival in rectal cancer; LUSC cis rs1577917 1.000 rs12208493 chr6:86662267 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.84 -0.35 3.68e-11 Response to antipsychotic treatment; LUSC cis rs3741151 0.764 rs79892955 chr11:73096280 G/T cg17517138 chr11:73019481 ARHGEF17 0.99 8.33 0.41 2.16e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 2.95e-13 Prudent dietary pattern; LUSC cis rs2762353 0.935 rs1165215 chr6:25798932 G/A cg12310025 chr6:25882481 NA -0.43 -7.4 -0.38 1.12e-12 Blood metabolite levels; LUSC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.65 0.34 1.19e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.32 0.53 2.36e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.57 -7.64 -0.39 2.26e-13 Renal function-related traits (BUN); LUSC cis rs7568458 0.660 rs2289972 chr2:85766545 C/T cg17127132 chr2:85788382 GGCX 0.44 6.26 0.32 1.17e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9393777 0.513 rs6924727 chr6:26491234 A/G cg12826209 chr6:26865740 GUSBL1 0.68 7.85 0.39 5.75e-14 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg27170947 chr2:26402098 FAM59B -0.65 -9.52 -0.46 3.75e-19 Gut microbiome composition (summer); LUSC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs9504361 0.808 rs3765437 chr6:563013 C/T cg15781525 chr6:564561 EXOC2 -0.36 -5.87 -0.31 1.03e-8 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes;Psoriasis;Pit-and-Fissure caries;Eosinophil counts; LUSC cis rs7937682 0.924 rs4630327 chr11:111539327 C/T cg09085632 chr11:111637200 PPP2R1B 1.11 18.39 0.71 1.19e-52 Primary sclerosing cholangitis; LUSC cis rs3741151 0.773 rs17244596 chr11:73179236 A/G cg17517138 chr11:73019481 ARHGEF17 0.97 8.24 0.41 3.9e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2933343 0.729 rs1683780 chr3:128640239 C/T cg11901034 chr3:128598214 ACAD9 -0.39 -6.0 -0.31 5.1e-9 IgG glycosylation; LUSC trans rs35110281 0.681 rs162343 chr21:44957072 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.79 0.47 4.54e-20 Mean corpuscular volume; LUSC trans rs853679 0.517 rs6941992 chr6:28106141 T/C cg06606381 chr12:133084897 FBRSL1 -0.45 -5.97 -0.31 6.07e-9 Depression; LUSC cis rs1595825 0.891 rs1030796 chr2:198674673 A/G cg10547527 chr2:198650123 BOLL -0.52 -6.03 -0.31 4.32e-9 Ulcerative colitis; LUSC trans rs62103177 0.810 rs62103188 chr18:77627661 G/A cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC trans rs11039798 0.920 rs116109043 chr11:48976940 C/T cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs6121246 0.567 rs6120879 chr20:30202961 T/C cg13852791 chr20:30311386 BCL2L1 0.77 8.74 0.43 1.15e-16 Mean corpuscular hemoglobin; LUSC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg21782813 chr7:2030301 MAD1L1 0.35 5.89 0.31 9.53e-9 Schizophrenia; LUSC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg26727032 chr16:67993705 SLC12A4 -0.45 -5.96 -0.31 6.44e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs921968 0.565 rs6436083 chr2:219639719 C/T cg02176678 chr2:219576539 TTLL4 -0.55 -9.78 -0.47 4.92e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs1950626 0.615 rs12893486 chr14:101463800 C/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.36 5.9 0.31 9.05e-9 Pelvic organ prolapse (moderate/severe); LUSC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg20573242 chr4:122745356 CCNA2 0.58 8.45 0.42 8.9e-16 Type 2 diabetes; LUSC cis rs4980532 1 rs4980532 chr11:63680719 C/T cg18290981 chr11:63789520 MACROD1 0.29 6.12 0.32 2.62e-9 Pulse pressure; LUSC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg11764359 chr7:65958608 NA 0.54 7.05 0.36 1.04e-11 Aortic root size; LUSC cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg12386194 chr3:101231763 SENP7 0.56 7.81 0.39 7.26e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.568 rs12772775 chr10:104702999 C/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.59 -0.34 1.71e-10 Arsenic metabolism; LUSC cis rs7605827 0.930 rs13030859 chr2:15701038 G/A cg19274914 chr2:15703543 NA 0.46 8.64 0.43 2.33e-16 Educational attainment (years of education); LUSC cis rs669446 0.533 rs3791042 chr1:44219275 T/C cg15962314 chr1:44399869 ARTN 0.24 5.81 0.3 1.49e-8 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg03161606 chr19:29218774 NA 0.61 9.03 0.44 1.38e-17 Methadone dose in opioid dependence; LUSC cis rs62244186 0.541 rs3804583 chr3:44884647 G/T cg02073558 chr3:44770973 ZNF501 0.56 9.16 0.45 5.55e-18 Depressive symptoms; LUSC cis rs4363385 0.626 rs6667103 chr1:153064438 A/G cg00922841 chr1:152955080 SPRR1A -0.35 -6.0 -0.31 5.06e-9 Inflammatory skin disease; LUSC cis rs763121 0.853 rs2413545 chr22:39092524 C/T cg14440974 chr22:39074834 NA -0.4 -6.47 -0.33 3.53e-10 Menopause (age at onset); LUSC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg20243544 chr17:37824526 PNMT 0.38 5.65 0.3 3.45e-8 Self-reported allergy; LUSC cis rs6542838 0.583 rs7565819 chr2:99519265 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.94 -0.31 7.24e-9 Fear of minor pain; LUSC cis rs11997175 0.766 rs4733178 chr8:33691899 A/T ch.8.33884649F chr8:33765107 NA 0.37 5.81 0.3 1.47e-8 Body mass index; LUSC cis rs568617 0.716 rs111953392 chr11:65595697 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.63 6.94 0.35 2.09e-11 Crohn's disease; LUSC cis rs56283067 0.887 rs4644056 chr6:44776136 G/T cg18551225 chr6:44695536 NA 0.47 7.38 0.37 1.29e-12 Total body bone mineral density; LUSC cis rs9921222 0.521 rs757460 chr16:367174 G/C cg02086790 chr16:375327 AXIN1 -0.37 -5.8 -0.3 1.53e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg04865166 chr7:105162814 PUS7 0.51 5.74 0.3 2.17e-8 Bipolar disorder (body mass index interaction); LUSC cis rs3106136 0.901 rs17623135 chr4:95213091 C/T cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.24 -0.32 1.33e-9 Capecitabine sensitivity; LUSC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs11229555 0.598 rs7930623 chr11:58197641 A/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg07031243 chr17:40976230 BECN1 0.38 6.06 0.31 3.6e-9 Schizophrenia (age at onset); LUSC trans rs7618501 0.540 rs11130241 chr3:50131459 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.59 -0.46 2.08e-19 Intelligence (multi-trait analysis); LUSC cis rs7617773 0.780 rs13085251 chr3:48340045 C/T cg20734569 chr3:48348370 SPINK8 -0.46 -7.81 -0.39 7.43e-14 Coronary artery disease; LUSC cis rs8014204 0.773 rs2241275 chr14:75251440 C/T cg06637938 chr14:75390232 RPS6KL1 -0.64 -10.68 -0.5 4.22e-23 Caffeine consumption; LUSC cis rs2235573 0.527 rs139866 chr22:38354684 C/T cg06521852 chr22:38141419 TRIOBP -0.35 -5.64 -0.3 3.57e-8 Glioblastoma;Glioma; LUSC cis rs7412746 0.611 rs2228099 chr1:150808889 C/G cg09034736 chr1:150693464 HORMAD1 0.5 7.42 0.38 9.93e-13 Melanoma; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg15190599 chr6:26156487 HIST1H1E 0.41 6.47 0.33 3.39e-10 Calcium levels; LUSC cis rs7918232 0.662 rs10764662 chr10:27300643 T/A cg14442939 chr10:27389572 ANKRD26 0.49 5.85 0.3 1.17e-8 Breast cancer; LUSC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg17385448 chr1:15911702 AGMAT 0.38 6.42 0.33 4.64e-10 Systolic blood pressure; LUSC cis rs874628 0.703 rs72999449 chr19:18237050 A/T cg00493341 chr19:18228948 MAST3 0.45 5.94 0.31 7.09e-9 Multiple sclerosis; LUSC cis rs9291683 0.527 rs3822241 chr4:10094931 G/A cg11266682 chr4:10021025 SLC2A9 -0.55 -9.93 -0.48 1.53e-20 Bone mineral density; LUSC cis rs4713675 0.565 rs1555965 chr6:33677400 A/G cg14003231 chr6:33640908 ITPR3 0.29 5.69 0.3 2.82e-8 Plateletcrit; LUSC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg14552801 chr7:65878734 NA -0.46 -6.53 -0.34 2.45e-10 Aortic root size; LUSC cis rs7424096 0.613 rs111805423 chr2:37248924 G/T cg14987922 chr2:37194071 STRN 0.61 8.27 0.41 3.18e-15 High light scatter reticulocyte percentage of red cells; LUSC trans rs62103177 0.608 rs34383580 chr18:77833263 A/G cg05926928 chr17:57297772 GDPD1 -0.89 -10.31 -0.49 8.13e-22 Opioid sensitivity; LUSC cis rs7937890 0.904 rs11023169 chr11:14290985 C/A cg02886208 chr11:14281011 SPON1 0.33 5.9 0.31 8.91e-9 Mitochondrial DNA levels; LUSC cis rs7000551 0.751 rs2449329 chr8:22374794 G/T cg12081754 chr8:22256438 SLC39A14 0.45 6.86 0.35 3.3e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs4332037 0.539 rs55988458 chr7:2059761 G/A cg11693508 chr17:37793320 STARD3 0.56 6.7 0.34 8.71e-11 Bipolar disorder; LUSC trans rs6502050 0.835 rs12600852 chr17:80104593 G/A cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg01483505 chr11:975446 AP2A2 0.41 5.9 0.31 8.84e-9 Alzheimer's disease (late onset); LUSC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg11344533 chr11:111475393 SIK2 -0.48 -6.49 -0.33 3.11e-10 Primary sclerosing cholangitis; LUSC cis rs2562456 0.754 rs11666213 chr19:21605645 G/A cg00806126 chr19:22604979 ZNF98 -0.4 -5.71 -0.3 2.43e-8 Pain; LUSC cis rs599083 0.530 rs640569 chr11:68184820 A/G cg01657329 chr11:68192670 LRP5 0.48 6.32 0.33 8.42e-10 Bone mineral density (spine); LUSC cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg11189052 chr15:85197271 WDR73 -0.59 -8.95 -0.44 2.5e-17 P wave terminal force; LUSC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg08975724 chr8:8085496 FLJ10661 0.55 8.27 0.41 3.32e-15 Mood instability; LUSC cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg12011299 chr4:100065546 ADH4 0.68 10.96 0.51 4.37e-24 Alcohol dependence; LUSC cis rs10197940 0.578 rs6718372 chr2:152345871 C/G cg19508488 chr2:152266495 RIF1 0.39 5.71 0.3 2.54e-8 Lung cancer; LUSC cis rs614226 1.000 rs1614223 chr12:120964043 T/C cg21053147 chr12:120880522 NA -0.49 -6.11 -0.32 2.77e-9 Type 1 diabetes nephropathy; LUSC trans rs35110281 0.805 rs2838319 chr21:44991901 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.76 0.47 5.95e-20 Mean corpuscular volume; LUSC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg27211696 chr2:191398769 TMEM194B 0.64 12.29 0.56 6.94e-29 Pulse pressure; LUSC cis rs7615316 0.902 rs6775718 chr3:142203235 G/T cg16271453 chr3:142027066 XRN1 -0.39 -6.68 -0.34 9.95e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2014572 0.967 rs10426174 chr19:57756055 G/A cg24459738 chr19:57751996 ZNF805 -0.52 -7.69 -0.39 1.66e-13 Hyperactive-impulsive symptoms; LUSC cis rs7605827 0.897 rs11892720 chr2:15674267 T/C cg19274914 chr2:15703543 NA 0.45 8.44 0.42 9.88e-16 Educational attainment (years of education); LUSC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg06740227 chr12:86229804 RASSF9 0.45 7.14 0.36 5.83e-12 Major depressive disorder; LUSC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.52 -7.31 -0.37 2.03e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg20744362 chr22:50050164 C22orf34 0.38 8.05 0.4 1.44e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9660992 0.674 rs17345837 chr1:205263122 C/T cg21545522 chr1:205238299 TMCC2 0.45 8.44 0.42 9.5e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs6484504 0.600 rs1323738 chr11:31344898 T/C cg26647111 chr11:31128758 NA 0.4 5.75 0.3 1.99e-8 Red blood cell count; LUSC cis rs11971779 0.527 rs4379397 chr7:139043385 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg00310523 chr12:86230176 RASSF9 0.47 8.52 0.42 5.52e-16 Major depressive disorder; LUSC cis rs4938330 0.608 rs2277287 chr11:117096652 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.18 -0.32 1.83e-9 Blood protein levels; LUSC trans rs35110281 0.563 rs162371 chr21:44931489 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.2 0.49 1.86e-21 Mean corpuscular volume; LUSC cis rs13315871 0.858 rs78946071 chr3:58318523 G/T cg12435725 chr3:58293450 RPP14 -0.74 -7.16 -0.36 5.15e-12 Cholesterol, total; LUSC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg00343986 chr7:65444356 GUSB 0.43 6.52 0.34 2.61e-10 Aortic root size; LUSC cis rs1595825 0.891 rs59938443 chr2:198497105 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg00944433 chr1:107599041 PRMT6 -0.38 -7.07 -0.36 9.07e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg04727924 chr7:799746 HEATR2 -0.57 -6.02 -0.31 4.67e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7582180 0.629 rs13010911 chr2:100953390 G/C cg14675211 chr2:100938903 LONRF2 0.37 5.72 0.3 2.38e-8 Intelligence (multi-trait analysis); LUSC cis rs1044826 0.692 rs169824 chr3:139235006 G/C cg15131784 chr3:139108705 COPB2 -0.4 -6.43 -0.33 4.38e-10 Obesity-related traits; LUSC cis rs3803170 0.513 rs10849941 chr12:111818487 A/T cg10833066 chr12:111807467 FAM109A 0.41 7.9 0.4 3.98e-14 Mean corpuscular hemoglobin; LUSC cis rs11039100 0.564 rs2047461 chr11:5783226 A/G cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs8017423 0.967 rs7147809 chr14:90715025 A/G cg04374321 chr14:90722782 PSMC1 0.76 12.09 0.55 3.56e-28 Mortality in heart failure; LUSC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg12963246 chr6:28129442 ZNF389 0.52 7.53 0.38 4.84e-13 Parkinson's disease; LUSC cis rs9297145 0.585 rs4729521 chr7:98780520 G/T cg05967295 chr7:98741636 SMURF1 -0.64 -10.06 -0.48 5.78e-21 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs73198271 0.710 rs7837843 chr8:8656485 A/G cg01851573 chr8:8652454 MFHAS1 0.47 7.74 0.39 1.22e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs796364 0.616 rs6718118 chr2:200691852 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.51 -5.97 -0.31 6.12e-9 Schizophrenia; LUSC cis rs62458065 0.640 rs6950077 chr7:32502895 A/G cg20159608 chr7:32802032 NA 0.72 9.29 0.45 1.96e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg14530993 chr4:882597 GAK -0.65 -7.16 -0.36 5.14e-12 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg04455712 chr21:45112962 RRP1B -0.48 -8.85 -0.44 5.03e-17 Mean corpuscular volume; LUSC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg00129232 chr17:37814104 STARD3 -0.43 -6.36 -0.33 6.5e-10 Asthma; LUSC cis rs72781680 0.898 rs72782136 chr2:24047344 A/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs611744 0.647 rs1584373 chr8:109263399 C/A cg18478394 chr8:109455254 TTC35 0.44 6.81 0.35 4.63e-11 Dupuytren's disease; LUSC cis rs9677476 0.863 rs57199832 chr2:232069083 T/G cg07929768 chr2:232055508 NA 0.36 6.99 0.36 1.48e-11 Food antigen IgG levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24412469 chr1:200590040 KIF14 0.4 6.06 0.31 3.66e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg21880101 chr17:80066754 CCDC57 -0.31 -5.85 -0.31 1.15e-8 Life satisfaction; LUSC cis rs4144743 0.938 rs55677902 chr17:45322572 G/T cg18085866 chr17:45331354 ITGB3 -0.75 -7.99 -0.4 2.18e-14 Body mass index; LUSC cis rs16912285 0.688 rs7109312 chr11:24338974 G/A ch.11.24196551F chr11:24239977 NA 0.85 8.08 0.4 1.18e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg02931644 chr1:25747376 RHCE -0.32 -5.76 -0.3 1.89e-8 Erythrocyte sedimentation rate; LUSC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg13206674 chr6:150067644 NUP43 -0.57 -9.09 -0.45 8.66e-18 Lung cancer; LUSC cis rs6964587 0.869 rs7793946 chr7:91520628 T/C cg17063962 chr7:91808500 NA -0.51 -7.81 -0.39 7.54e-14 Breast cancer; LUSC cis rs1160297 0.609 rs1828338 chr2:53096951 T/C cg07782112 chr2:53107842 NA 0.41 6.58 0.34 1.79e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg08067268 chr2:26466485 HADHB;HADHA -0.55 -8.2 -0.41 5.16e-15 Gut microbiome composition (summer); LUSC cis rs4253772 1.000 rs4253766 chr22:46623905 C/T cg24881330 chr22:46731750 TRMU 0.68 6.52 0.34 2.56e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.67e-9 Systolic blood pressure; LUSC cis rs9486719 1.000 rs2499809 chr6:96870110 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs1524927 0.966 rs11772629 chr7:96332857 C/G cg03808172 chr7:96339361 SHFM1 0.45 6.88 0.35 3.01e-11 Total body bone mineral density; LUSC cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg03709012 chr19:19516395 GATAD2A 0.74 11.31 0.53 2.46e-25 Tonsillectomy; LUSC cis rs10752881 1.000 rs12028732 chr1:182985525 G/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.02 -0.4 1.76e-14 Intelligence (multi-trait analysis); LUSC trans rs17597773 0.638 rs12145674 chr1:221000273 C/T cg25786136 chr2:222575520 NA -0.4 -6.16 -0.32 2.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg13206674 chr6:150067644 NUP43 0.56 8.91 0.44 3.36e-17 Lung cancer; LUSC trans rs9329221 0.507 rs12678938 chr8:10016969 C/T cg21775007 chr8:11205619 TDH -0.47 -6.64 -0.34 1.29e-10 Neuroticism; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.33 0.56 4.75e-29 Prudent dietary pattern; LUSC cis rs6542838 0.671 rs6752025 chr2:99505699 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.53 -7.18 -0.37 4.63e-12 Fear of minor pain; LUSC cis rs2637266 0.935 rs12772269 chr10:78394292 C/A cg18941641 chr10:78392320 NA 0.42 7.62 0.38 2.59e-13 Pulmonary function; LUSC cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg05855489 chr10:104503620 C10orf26 -0.67 -9.52 -0.46 3.64e-19 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7818345 0.967 rs13255677 chr8:19288985 C/T cg11303988 chr8:19266685 CSGALNACT1 0.36 6.9 0.35 2.59e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg09359103 chr1:154839909 KCNN3 -0.72 -17.35 -0.69 1.58e-48 Prostate cancer; LUSC cis rs11792861 0.926 rs12686736 chr9:111888739 A/G cg13535736 chr9:111863775 C9orf5 -0.41 -6.77 -0.35 5.83e-11 Menarche (age at onset); LUSC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg16743903 chr16:89593216 SPG7 0.36 5.67 0.3 3.08e-8 Multiple myeloma (IgH translocation); LUSC cis rs2658782 1.000 rs2658778 chr11:93148948 C/G cg15737290 chr11:93063684 CCDC67 0.64 7.9 0.4 4.07e-14 Pulmonary function decline; LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg08859206 chr1:53392774 SCP2 0.49 8.26 0.41 3.56e-15 Monocyte count; LUSC cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg13256891 chr4:100009986 ADH5 0.44 5.86 0.31 1.1e-8 Alcohol dependence; LUSC cis rs138544659 1 rs138544659 chr15:78900701 T/G cg06917634 chr15:78832804 PSMA4 -0.44 -5.91 -0.31 8.24e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema distribution in smoking;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9467711 0.606 rs9358939 chr6:26416787 C/G cg09904177 chr6:26538194 HMGN4 -0.74 -6.83 -0.35 4.11e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs10193935 0.901 rs10200000 chr2:42442212 A/G cg27598129 chr2:42591480 NA -0.64 -8.68 -0.43 1.83e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg01097406 chr16:89675127 NA 0.32 5.67 0.3 3.08e-8 Vitiligo; LUSC cis rs60154123 0.730 rs4844987 chr1:210458190 G/T cg22029157 chr1:209979665 IRF6 0.51 5.84 0.3 1.23e-8 Coronary artery disease; LUSC cis rs4622329 0.636 rs4764665 chr12:102287929 G/T cg23541617 chr12:102225335 GNPTAB 0.27 6.39 0.33 5.47e-10 Systemic lupus erythematosus; LUSC cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.36 -0.33 6.55e-10 Extrinsic epigenetic age acceleration; LUSC trans rs11098499 0.657 rs7664458 chr4:120371967 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs10740039 0.883 rs10821809 chr10:62397370 A/G cg18175470 chr10:62150864 ANK3 -0.46 -6.85 -0.35 3.59e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg05738196 chr6:26577821 NA 0.47 7.0 0.36 1.39e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg00825309 chr19:58991885 ZNF446 0.48 7.1 0.36 7.55e-12 Uric acid clearance; LUSC cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg24642439 chr20:33292090 TP53INP2 0.73 12.05 0.55 5.05e-28 Coronary artery disease; LUSC cis rs10751667 0.666 rs7105477 chr11:964271 C/G ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.1e-10 Alzheimer's disease (late onset); LUSC cis rs9527 0.615 rs4917991 chr10:104783833 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.15e-10 Arsenic metabolism; LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs1003719 0.788 rs2835605 chr21:38490734 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.24 0.52 4.29e-25 Eye color traits; LUSC cis rs9326248 0.509 rs533556 chr11:116741572 A/C cg10130564 chr11:117069849 TAGLN 0.3 5.79 0.3 1.65e-8 Blood protein levels; LUSC cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg03146154 chr1:46216737 IPP 0.51 7.67 0.39 1.84e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 8.26 0.41 3.44e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12540874 0.529 rs732215 chr7:50544063 A/C cg18232548 chr7:50535776 DDC -0.65 -9.65 -0.47 1.3e-19 Systemic sclerosis; LUSC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.59 0.38 3.33e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10140922 0.966 rs10083387 chr14:35823669 G/A cg07166546 chr14:35805898 NA -0.26 -6.31 -0.33 8.77e-10 Hip circumference adjusted for BMI; LUSC cis rs11105298 0.891 rs10858909 chr12:89935387 C/T cg00757033 chr12:89920650 WDR51B 0.61 10.59 0.5 8.76e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -7.99 -0.4 2.19e-14 Chronic sinus infection; LUSC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.84 0.3 1.21e-8 Intelligence (multi-trait analysis); LUSC cis rs3806843 1.000 rs13157397 chr5:140184442 G/A cg19875535 chr5:140030758 IK 0.52 8.43 0.42 1.04e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg16405210 chr4:1374714 KIAA1530 0.55 8.21 0.41 4.9e-15 Obesity-related traits; LUSC cis rs8017423 0.647 rs10132599 chr14:90815342 C/T cg04374321 chr14:90722782 PSMC1 -0.47 -7.25 -0.37 2.99e-12 Mortality in heart failure; LUSC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.52 -7.15 -0.36 5.4e-12 Mean platelet volume; LUSC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg06640241 chr16:89574553 SPG7 0.71 11.25 0.52 4.02e-25 Multiple myeloma (IgH translocation); LUSC cis rs908922 0.676 rs11205032 chr1:152527690 A/G cg20991723 chr1:152506922 NA 0.51 9.59 0.46 2.12e-19 Hair morphology; LUSC cis rs79387448 0.745 rs6742433 chr2:103175360 C/T cg09003973 chr2:102972529 NA 0.88 8.38 0.42 1.52e-15 Gut microbiota (bacterial taxa); LUSC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.49 -0.38 6.39e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18099408 chr3:52552593 STAB1 -0.4 -7.03 -0.36 1.19e-11 Electroencephalogram traits; LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs6062509 0.965 rs2315008 chr20:62343956 T/G cg01176363 chr20:62369445 LIME1 -0.47 -7.14 -0.36 5.85e-12 Prostate cancer; LUSC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.44 -7.98 -0.4 2.29e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1775715 0.737 rs2808090 chr10:32143208 A/C cg03015672 chr10:32216066 ARHGAP12 0.33 6.02 0.31 4.59e-9 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00993799 chr7:104653126 LOC100216545 0.41 7.39 0.37 1.15e-12 Triglycerides; LUSC cis rs66887589 0.560 rs9684327 chr4:120365441 A/G cg09307838 chr4:120376055 NA 0.46 6.93 0.35 2.18e-11 Diastolic blood pressure; LUSC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg17340268 chr14:105411764 AHNAK2 -0.38 -6.07 -0.32 3.45e-9 Rheumatoid arthritis; LUSC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg06636001 chr8:8085503 FLJ10661 -0.68 -11.46 -0.53 6.98e-26 Mood instability; LUSC trans rs11250098 0.503 rs7821826 chr8:10769439 C/T cg15556689 chr8:8085844 FLJ10661 -0.57 -8.09 -0.4 1.14e-14 Morning vs. evening chronotype; LUSC cis rs13385 0.769 rs59443048 chr5:139602802 C/A cg26211634 chr5:139558579 C5orf32 0.45 6.57 0.34 1.96e-10 Atrial fibrillation; LUSC trans rs2162440 0.571 rs1427042 chr18:35208228 T/C cg00460916 chr17:3698239 ITGAE 0.53 6.01 0.31 4.95e-9 Telomere length; LUSC cis rs981844 0.775 rs17371261 chr4:154738479 G/T cg14289246 chr4:154710475 SFRP2 -0.47 -6.46 -0.33 3.69e-10 Response to statins (LDL cholesterol change); LUSC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg18190219 chr22:46762943 CELSR1 -0.48 -5.94 -0.31 7.32e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs698813 0.637 rs4952706 chr2:44500536 T/C cg00619915 chr2:44497795 NA -0.52 -6.99 -0.36 1.54e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs10089 1.000 rs77086350 chr5:127494431 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.85 11.19 0.52 6.7e-25 Ileal carcinoids; LUSC cis rs7592578 0.766 rs35818159 chr2:191409616 C/G cg11845111 chr2:191398756 TMEM194B -0.88 -10.76 -0.51 2.31e-23 Diastolic blood pressure; LUSC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg12927641 chr6:109611667 NA -0.35 -5.9 -0.31 8.95e-9 Reticulocyte fraction of red cells; LUSC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg25072359 chr17:41440525 NA 0.65 9.39 0.46 9.33e-19 Menopause (age at onset); LUSC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg07701084 chr6:150067640 NUP43 0.52 7.78 0.39 8.84e-14 Lung cancer; LUSC cis rs9905704 0.914 rs2611777 chr17:56826958 A/G cg12560992 chr17:57184187 TRIM37 0.56 7.89 0.4 4.39e-14 Testicular germ cell tumor; LUSC cis rs3733585 0.654 rs4447863 chr4:9938969 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -8.75 -0.43 1.08e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7215564 0.908 rs7501674 chr17:78662177 C/T cg23238734 chr17:78661607 RPTOR 0.46 5.95 0.31 6.75e-9 Myopia (pathological); LUSC cis rs6580649 0.941 rs57380031 chr12:48452237 C/T cg24011408 chr12:48396354 COL2A1 -0.46 -6.17 -0.32 1.95e-9 Lung cancer; LUSC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.45 6.01 0.31 4.94e-9 Renal function-related traits (BUN); LUSC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg22920501 chr2:26401640 FAM59B 0.71 8.66 0.43 2.02e-16 Gut microbiome composition (summer); LUSC cis rs61931739 0.817 rs11053071 chr12:34201400 A/G cg06521331 chr12:34319734 NA -0.36 -6.11 -0.32 2.77e-9 Morning vs. evening chronotype; LUSC cis rs2236918 0.687 rs1776176 chr1:242012554 C/T cg17736920 chr1:242011382 EXO1 0.43 6.85 0.35 3.52e-11 Menopause (age at onset); LUSC cis rs861020 0.606 rs689210 chr1:210013723 A/C cg05527609 chr1:210001259 C1orf107 0.71 10.3 0.49 8.45e-22 Orofacial clefts; LUSC trans rs7647973 0.593 rs59684465 chr3:49874246 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.63 7.51 0.38 5.4e-13 Menarche (age at onset); LUSC cis rs78456975 0.622 rs11888851 chr2:1518254 C/G cg12573674 chr2:1569213 NA -0.46 -5.96 -0.31 6.26e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg23982607 chr1:1823379 GNB1 0.54 9.98 0.48 1.07e-20 Body mass index; LUSC cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.25 0.59 1.67e-32 Chronic sinus infection; LUSC cis rs6840360 0.642 rs1443088 chr4:152450126 G/A cg20465933 chr4:152376761 FAM160A1 0.32 5.77 0.3 1.85e-8 Intelligence (multi-trait analysis); LUSC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.16 0.52 8.94e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs751728 1.000 rs4713682 chr6:33757047 G/C cg25922239 chr6:33757077 LEMD2 0.55 8.24 0.41 4.05e-15 Crohn's disease; LUSC trans rs1325195 0.881 rs2791941 chr1:179112435 G/A cg11624085 chr17:8464688 MYH10 0.43 7.11 0.36 6.97e-12 IgE grass sensitization; LUSC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg14019146 chr3:50243930 SLC38A3 -0.32 -7.06 -0.36 9.67e-12 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.94 0.4 3.06e-14 Bipolar disorder; LUSC cis rs9818941 0.824 rs12632906 chr3:157726384 T/A cg08654915 chr3:157813417 NA -0.32 -7.39 -0.37 1.23e-12 Height; LUSC cis rs11048434 0.736 rs2377672 chr12:9112414 A/G cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC cis rs4332037 0.851 rs10268609 chr7:1962163 A/C cg23422044 chr7:1970798 MAD1L1 -0.62 -7.23 -0.37 3.36e-12 Bipolar disorder; LUSC cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs9309711 0.922 rs13431788 chr2:3482912 G/A cg10845886 chr2:3471009 TTC15 -0.62 -7.95 -0.4 2.92e-14 Neurofibrillary tangles; LUSC cis rs1775715 0.707 rs2778669 chr10:32161541 C/T cg03015672 chr10:32216066 ARHGAP12 0.33 6.01 0.31 4.87e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg23229984 chr5:148520753 ABLIM3 0.41 6.01 0.31 4.94e-9 Breast cancer; LUSC cis rs9361491 0.543 rs1507153 chr6:79484386 C/A cg05283184 chr6:79620031 NA -0.44 -8.04 -0.4 1.55e-14 Intelligence (multi-trait analysis); LUSC cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg16230307 chr14:35515116 FAM177A1 0.81 10.35 0.49 5.97e-22 Psoriasis; LUSC cis rs765787 0.530 rs4775836 chr15:45537664 T/C cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg00071950 chr4:10020882 SLC2A9 0.64 10.49 0.5 1.86e-22 Bone mineral density; LUSC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg16584290 chr5:462447 EXOC3 -0.36 -6.24 -0.32 1.34e-9 Cystic fibrosis severity; LUSC cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg24375607 chr4:120327624 NA 0.78 11.58 0.54 2.65e-26 Corneal astigmatism; LUSC cis rs9388451 0.537 rs1739383 chr6:126098915 G/T cg05901451 chr6:126070800 HEY2 -0.76 -12.96 -0.58 2.07e-31 Brugada syndrome; LUSC cis rs6500602 0.727 rs4786509 chr16:4568769 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.55 -7.4 -0.38 1.12e-12 Schizophrenia; LUSC cis rs113835537 0.935 rs1127145 chr11:66373305 G/A cg24851651 chr11:66362959 CCS 0.52 6.4 0.33 5.11e-10 Airway imaging phenotypes; LUSC cis rs4280164 0.945 rs1131941 chr14:24760808 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.58 -6.73 -0.35 7.18e-11 Parent of origin effect on language impairment (paternal); LUSC cis rs1346 0.552 rs10791820 chr11:65366847 C/T cg17120908 chr11:65337727 SSSCA1 -0.41 -5.72 -0.3 2.31e-8 Vertical cup-disc ratio;Optic cup area; LUSC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg25036284 chr2:26402008 FAM59B -0.72 -9.87 -0.48 2.57e-20 Gut microbiome composition (summer); LUSC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg23625390 chr15:77176239 SCAPER 0.46 7.0 0.36 1.44e-11 Blood metabolite levels; LUSC cis rs2579519 0.547 rs11683523 chr2:96544855 T/C cg22654517 chr2:96458247 NA 0.37 6.92 0.35 2.33e-11 Diastolic blood pressure; LUSC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs4964805 0.594 rs10861096 chr12:104169356 C/T cg02344784 chr12:104178138 NT5DC3 0.37 6.01 0.31 4.95e-9 Attention deficit hyperactivity disorder; LUSC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg19729930 chr2:74357872 NA 0.89 16.74 0.68 4.36e-46 Gestational age at birth (maternal effect); LUSC cis rs8014204 0.762 rs973879 chr14:75297727 T/C cg06637938 chr14:75390232 RPS6KL1 0.51 8.09 0.4 1.14e-14 Caffeine consumption; LUSC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg12463550 chr7:65579703 CRCP -0.52 -7.63 -0.39 2.44e-13 Aortic root size; LUSC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg06022373 chr22:39101656 GTPBP1 0.8 12.4 0.56 2.59e-29 Menopause (age at onset); LUSC cis rs500891 1.000 rs13205618 chr6:84177713 C/T cg08257003 chr6:84140564 ME1 0.34 7.12 0.36 6.55e-12 Platelet-derived growth factor BB levels; LUSC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg20283391 chr11:68216788 NA -0.57 -8.1 -0.41 1.03e-14 Total body bone mineral density; LUSC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg14092988 chr3:52407081 DNAH1 0.43 7.47 0.38 7.05e-13 Bipolar disorder; LUSC cis rs870825 0.929 rs10015218 chr4:185589789 T/C cg04058563 chr4:185651563 MLF1IP 0.81 10.66 0.5 4.96e-23 Blood protein levels; LUSC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg22508957 chr16:3507546 NAT15 -0.39 -6.12 -0.32 2.68e-9 Body mass index (adult); LUSC cis rs950776 0.518 rs4887062 chr15:78837801 G/A cg06917634 chr15:78832804 PSMA4 -0.8 -14.02 -0.61 1.89e-35 Sudden cardiac arrest; LUSC cis rs10870270 1.000 rs7098014 chr10:133775029 G/A cg08754478 chr10:133766260 PPP2R2D -0.61 -7.67 -0.39 1.9e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg03929089 chr4:120376271 NA 0.69 7.78 0.39 9.14e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs2236918 0.687 rs1776136 chr1:242026845 G/A cg17736920 chr1:242011382 EXO1 0.42 6.76 0.35 5.99e-11 Menopause (age at onset); LUSC cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg00409905 chr10:38381863 ZNF37A -0.37 -6.29 -0.33 9.68e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2832077 0.506 rs2832081 chr21:30152992 A/C cg24692254 chr21:30365293 RNF160 0.51 6.72 0.35 7.9e-11 Cognitive test performance; LUSC cis rs877282 0.945 rs10904555 chr10:787740 C/A cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs920590 0.573 rs4392917 chr8:19680635 G/C cg03894339 chr8:19674705 INTS10 -0.43 -6.07 -0.32 3.53e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs2486288 0.656 rs11639420 chr15:45559268 A/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.01e-14 Glomerular filtration rate; LUSC cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.51 0.42 5.86e-16 Colorectal cancer; LUSC cis rs763121 0.886 rs1013339 chr22:38974680 C/T cg06544989 chr22:39130855 UNC84B 0.37 6.61 0.34 1.49e-10 Menopause (age at onset); LUSC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg13057898 chr1:3703894 LRRC47 0.52 9.03 0.44 1.45e-17 Red cell distribution width; LUSC cis rs1153858 1.000 rs1613559 chr15:45622116 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.15 0.41 7.42e-15 Homoarginine levels; LUSC cis rs12594515 1.000 rs58368732 chr15:45990531 G/C cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg10172584 chr19:19639581 YJEFN3 -0.46 -5.65 -0.3 3.42e-8 Bipolar disorder; LUSC cis rs2243480 1.000 rs2243480 chr7:65599196 C/T cg18252515 chr7:66147081 NA -1.03 -11.43 -0.53 9.01e-26 Diabetic kidney disease; LUSC cis rs6076065 0.676 rs4813490 chr20:23325150 A/G cg11657817 chr20:23433608 CST11 0.45 8.36 0.42 1.71e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs6598955 0.671 rs6658935 chr1:26568912 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -5.67 -0.3 3.16e-8 Obesity-related traits; LUSC cis rs2204008 0.560 rs4129033 chr12:38301897 A/T cg13010199 chr12:38710504 ALG10B -0.47 -6.98 -0.36 1.58e-11 Bladder cancer; LUSC cis rs240764 0.817 rs239226 chr6:101107969 G/C cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg06008330 chr7:65541103 ASL -0.41 -6.44 -0.33 4.23e-10 Aortic root size; LUSC cis rs34779708 0.966 rs4934734 chr10:35434373 T/C cg03585969 chr10:35415529 CREM 0.6 8.79 0.43 8.31e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.55 -0.42 4.55e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7615952 0.515 rs7630575 chr3:125682330 A/G cg07211511 chr3:129823064 LOC729375 -0.78 -10.66 -0.5 5.09e-23 Blood pressure (smoking interaction); LUSC cis rs9467773 0.596 rs2494693 chr6:26619226 T/C cg09904177 chr6:26538194 HMGN4 0.65 11.67 0.54 1.3e-26 Intelligence (multi-trait analysis); LUSC cis rs4969178 0.965 rs11653305 chr17:76386918 T/C cg20026190 chr17:76395443 PGS1 0.45 7.82 0.39 7.14e-14 HDL cholesterol levels; LUSC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs62458065 0.713 rs3801329 chr7:32496956 A/C cg20159608 chr7:32802032 NA -0.73 -9.16 -0.45 5.55e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs17401966 0.838 rs12141246 chr1:10327407 A/T cg19773385 chr1:10388646 KIF1B -0.49 -8.48 -0.42 7.19e-16 Hepatocellular carcinoma; LUSC cis rs8060686 0.516 rs12599238 chr16:68276235 G/A cg27539214 chr16:67997921 SLC12A4 -0.58 -6.92 -0.35 2.3e-11 HDL cholesterol;Metabolic syndrome; LUSC trans rs6030 0.957 rs2239852 chr1:169512524 C/T cg16792071 chr10:134842795 NA 0.29 6.19 0.32 1.79e-9 Uric acid levels; LUSC cis rs4343996 0.754 rs4327753 chr7:3372249 C/G cg21248987 chr7:3385318 SDK1 -0.37 -6.34 -0.33 7.33e-10 Motion sickness; LUSC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg05340658 chr4:99064831 C4orf37 0.68 11.57 0.53 2.84e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg01238044 chr22:24384105 GSTT1 0.5 7.03 0.36 1.14e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg21285383 chr16:89894308 SPIRE2 0.3 5.83 0.3 1.31e-8 Vitiligo; LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg21782813 chr7:2030301 MAD1L1 0.38 6.17 0.32 1.95e-9 Bipolar disorder and schizophrenia; LUSC cis rs11711311 1.000 rs9828099 chr3:113518402 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.87 0.35 3.08e-11 IgG glycosylation; LUSC cis rs9398803 0.830 rs2039735 chr6:126745076 T/C cg19875578 chr6:126661172 C6orf173 0.43 6.27 0.32 1.11e-9 Male-pattern baldness; LUSC cis rs1372520 0.577 rs2737028 chr4:90717016 A/G cg15133208 chr4:90757351 SNCA -0.53 -8.19 -0.41 5.53e-15 Neuroticism; LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg18758796 chr5:131593413 PDLIM4 0.44 7.41 0.38 1.04e-12 Blood metabolite levels; LUSC cis rs9287719 0.839 rs7600695 chr2:10739945 A/G cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 6.84 0.35 3.71e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7177699 0.567 rs67745769 chr15:79124832 G/A cg15571903 chr15:79123663 NA -0.34 -6.26 -0.32 1.16e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg00784671 chr22:46762841 CELSR1 -0.49 -6.7 -0.34 9.04e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs709400 0.663 rs1028613 chr14:103888324 G/A cg12935359 chr14:103987150 CKB -0.56 -8.6 -0.43 3.13e-16 Body mass index; LUSC cis rs478304 0.654 rs10896035 chr11:65461160 G/A cg05805236 chr11:65401703 PCNXL3 -0.65 -10.68 -0.5 4.33e-23 Acne (severe); LUSC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg23758822 chr17:41437982 NA 1.0 15.85 0.66 1.34e-42 Menopause (age at onset); LUSC cis rs10465746 0.967 rs6576956 chr1:84343885 T/G cg10977910 chr1:84465055 TTLL7 0.45 6.39 0.33 5.52e-10 Obesity-related traits; LUSC trans rs2288327 0.915 rs2303838 chr2:179444939 C/T cg14011486 chr1:26737247 LIN28 0.47 5.95 0.31 6.87e-9 Atrial fibrillation; LUSC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg03929089 chr4:120376271 NA -0.53 -7.43 -0.38 9.25e-13 Coronary artery disease; LUSC trans rs7939886 0.920 rs10501343 chr11:55759573 G/T cg15704280 chr7:45808275 SEPT13 0.84 7.06 0.36 9.96e-12 Myopia (pathological); LUSC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg15782153 chr7:917662 C7orf20 0.43 6.49 0.33 3.09e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs7267979 0.899 rs442834 chr20:25458096 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.83 0.75 2.5e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs977987 0.806 rs12917651 chr16:75466696 G/T cg03315344 chr16:75512273 CHST6 0.5 9.52 0.46 3.5e-19 Dupuytren's disease; LUSC cis rs12579753 0.956 rs11115038 chr12:82214660 T/G cg07988820 chr12:82153109 PPFIA2 -0.44 -6.12 -0.32 2.61e-9 Resting heart rate; LUSC cis rs17828380 0.920 rs71394508 chr15:63603615 C/T cg05507819 chr15:63340323 TPM1 -0.77 -6.31 -0.33 8.71e-10 Social communication problems; LUSC cis rs9788682 0.747 rs2568485 chr15:78752114 C/T cg06917634 chr15:78832804 PSMA4 0.47 5.97 0.31 5.95e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11583043 0.918 rs6693456 chr1:101424561 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.94 0.31 7.17e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.75 0.35 6.45e-11 Menarche (age at onset); LUSC trans rs2736345 0.516 rs9657551 chr8:11398183 A/G cg15556689 chr8:8085844 FLJ10661 0.44 6.38 0.33 5.77e-10 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg23719950 chr11:63933701 MACROD1 0.6 8.04 0.4 1.55e-14 Mean platelet volume; LUSC cis rs9372253 0.678 rs9372251 chr6:110700656 A/G cg01119278 chr6:110721349 DDO -0.44 -7.8 -0.39 7.79e-14 Platelet distribution width; LUSC cis rs7927771 0.800 rs11039200 chr11:47379646 A/C cg20307385 chr11:47447363 PSMC3 -0.5 -6.3 -0.33 9.36e-10 Subjective well-being; LUSC cis rs7577696 0.962 rs212679 chr2:32431107 C/A cg02381751 chr2:32503542 YIPF4 0.41 5.92 0.31 8.06e-9 Inflammatory biomarkers; LUSC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg18099408 chr3:52552593 STAB1 0.36 5.98 0.31 5.74e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1801251 1.000 rs2592102 chr2:233726772 G/T cg08000102 chr2:233561755 GIGYF2 -0.68 -11.17 -0.52 7.7e-25 Coronary artery disease; LUSC cis rs7178572 0.568 rs12908262 chr15:77493256 G/A cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC trans rs7824557 0.872 rs6601577 chr8:11102682 C/G cg06636001 chr8:8085503 FLJ10661 0.51 8.02 0.4 1.76e-14 Retinal vascular caliber; LUSC cis rs11583043 0.546 rs6688545 chr1:101590335 G/A cg11406453 chr1:101602562 NA -0.41 -6.82 -0.35 4.4e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs2267137 0.903 rs2283850 chr22:29772391 G/C cg07256473 chr22:29710276 RASL10A 0.38 7.37 0.37 1.38e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg13798780 chr7:105162888 PUS7 0.55 6.08 0.32 3.27e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9487051 1.000 rs6568571 chr6:109613252 A/T cg00509249 chr6:109615579 CCDC162 -0.33 -5.77 -0.3 1.78e-8 Reticulocyte fraction of red cells; LUSC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.25 -0.32 1.23e-9 Breast cancer; LUSC cis rs6500602 0.767 rs8060219 chr16:4480158 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.47 6.07 0.32 3.5e-9 Schizophrenia; LUSC cis rs2652834 0.851 rs9888735 chr15:63410141 G/A cg05507819 chr15:63340323 TPM1 0.46 5.94 0.31 7.3e-9 HDL cholesterol; LUSC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg05340658 chr4:99064831 C4orf37 0.63 9.84 0.47 3.15e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg04518342 chr5:131593106 PDLIM4 0.34 6.33 0.33 7.73e-10 Blood metabolite levels; LUSC trans rs6981523 0.553 rs2409730 chr8:11060638 C/A cg08975724 chr8:8085496 FLJ10661 -0.5 -6.84 -0.35 3.85e-11 Neuroticism; LUSC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg08132940 chr7:1081526 C7orf50 -0.47 -6.0 -0.31 5.24e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.51 -6.84 -0.35 3.68e-11 Tonsillectomy; LUSC cis rs6906287 0.647 rs12206329 chr6:118863789 G/T cg21191810 chr6:118973309 C6orf204 0.33 5.95 0.31 6.92e-9 Electrocardiographic conduction measures; LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.82 0.3 1.4e-8 Tonsillectomy; LUSC cis rs2742417 0.603 rs2673075 chr3:45778288 C/A cg10512202 chr3:45649293 LIMD1 0.36 6.06 0.31 3.57e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4478858 0.735 rs10914368 chr1:31847937 A/G cg00250761 chr1:31883323 NA -0.36 -8.52 -0.42 5.4e-16 Alcohol dependence; LUSC cis rs10493773 0.609 rs11161651 chr1:86177816 A/G cg17807903 chr1:86174739 ZNHIT6 -0.54 -14.73 -0.63 3.31e-38 Urate levels in overweight individuals; LUSC cis rs4595586 0.655 rs4142847 chr12:39395128 C/T cg26384229 chr12:38710491 ALG10B 0.43 5.93 0.31 7.46e-9 Morning vs. evening chronotype; LUSC cis rs868036 0.681 rs28626095 chr15:68066729 T/C cg27219399 chr15:67835830 MAP2K5 0.36 5.95 0.31 6.94e-9 Restless legs syndrome; LUSC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.52 -0.34 2.63e-10 Total body bone mineral density; LUSC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.46 -0.38 7.79e-13 Aortic root size; LUSC cis rs72781680 0.898 rs17763224 chr2:24213776 T/C cg20701182 chr2:24300061 SF3B14 0.59 6.26 0.32 1.21e-9 Lymphocyte counts; LUSC cis rs7584330 0.737 rs10445707 chr2:238368751 A/G cg16989719 chr2:238392110 NA -0.37 -6.51 -0.34 2.78e-10 Prostate cancer; LUSC cis rs7605827 0.930 rs2058869 chr2:15679700 T/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs1971762 0.563 rs7958775 chr12:54077556 T/C cg23533419 chr12:54090519 NA -0.37 -6.02 -0.31 4.6e-9 Height; LUSC cis rs1451375 0.698 rs56766899 chr7:50648938 T/C cg18232548 chr7:50535776 DDC 0.5 7.58 0.38 3.49e-13 Malaria; LUSC trans rs10518128 1.000 rs10011543 chr4:75711122 C/T cg04432875 chr13:113411561 ATP11A 0.54 6.02 0.31 4.5e-9 Electroencephalogram traits; LUSC cis rs3087591 0.659 rs2214538 chr17:29636570 C/T cg24425628 chr17:29625626 OMG;NF1 0.48 7.2 0.37 4.09e-12 Hip circumference; LUSC cis rs5769707 0.542 rs739242 chr22:50057116 A/G cg10356904 chr22:49881777 NA -0.29 -5.91 -0.31 8.54e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9790314 0.905 rs7613358 chr3:160949296 T/C cg03342759 chr3:160939853 NMD3 -0.56 -9.5 -0.46 4.15e-19 Morning vs. evening chronotype; LUSC cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg17063962 chr7:91808500 NA 0.6 9.29 0.45 2.11e-18 Breast cancer; LUSC trans rs9329221 0.521 rs17693945 chr8:10106010 C/T cg15556689 chr8:8085844 FLJ10661 -0.56 -8.13 -0.41 8.75e-15 Neuroticism; LUSC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg06108461 chr20:60628389 TAF4 -1.01 -17.18 -0.68 7.55e-48 Body mass index; LUSC cis rs3741151 0.773 rs7115055 chr11:73227827 T/C cg17517138 chr11:73019481 ARHGEF17 0.96 8.06 0.4 1.35e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg00149659 chr3:10157352 C3orf10 1.0 14.11 0.61 8.69e-36 Alzheimer's disease; LUSC cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg23711669 chr6:146136114 FBXO30 -0.89 -16.79 -0.68 2.69e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg06634786 chr22:41940651 POLR3H 0.49 5.73 0.3 2.21e-8 Vitiligo; LUSC cis rs11785400 0.753 rs9773415 chr8:143731170 G/A cg10596483 chr8:143751796 JRK 0.53 7.59 0.38 3.21e-13 Schizophrenia; LUSC cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg23788917 chr6:8435910 SLC35B3 0.49 7.31 0.37 1.98e-12 Motion sickness; LUSC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg09034736 chr1:150693464 HORMAD1 0.44 6.26 0.32 1.18e-9 Melanoma; LUSC trans rs35110281 0.776 rs229357 chr21:44982717 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 11.23 0.52 4.84e-25 Mean corpuscular volume; LUSC cis rs6669072 1.000 rs6669072 chr1:91247345 C/T cg08895590 chr1:91227319 NA -0.37 -8.25 -0.41 3.6e-15 Cognitive function; LUSC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg06618935 chr21:46677482 NA -0.38 -7.52 -0.38 5.23e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs12682352 0.602 rs11783966 chr8:8665147 A/G cg21775007 chr8:11205619 TDH -0.44 -6.08 -0.32 3.32e-9 Neuroticism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10891507 chr20:56285236 PMEPA1 0.7 6.24 0.32 1.31e-9 Cognitive performance; LUSC cis rs8017423 0.630 rs4904678 chr14:90821670 T/C cg04374321 chr14:90722782 PSMC1 -0.43 -6.51 -0.34 2.72e-10 Mortality in heart failure; LUSC cis rs62400317 0.859 rs12193720 chr6:45103362 A/G cg20913747 chr6:44695427 NA -0.46 -7.41 -0.38 1.05e-12 Total body bone mineral density; LUSC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg06238570 chr21:40685208 BRWD1 0.47 7.25 0.37 2.94e-12 Cognitive function; LUSC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg14061069 chr19:46274453 DMPK 0.67 13.86 0.6 8.31e-35 Coronary artery disease; LUSC trans rs12210905 0.925 rs9467965 chr6:26992539 G/C cg11837749 chr1:55047332 ACOT11 0.55 6.0 0.31 5.25e-9 Hip circumference adjusted for BMI; LUSC cis rs2540226 0.844 rs12624217 chr2:39997694 C/T cg23576258 chr2:39999331 THUMPD2 0.34 5.75 0.3 1.99e-8 Personality dimensions; LUSC cis rs4888262 0.508 rs6564153 chr16:74658723 A/C cg01733217 chr16:74700730 RFWD3 0.77 12.34 0.56 4.38e-29 Testicular germ cell tumor; LUSC cis rs9646944 0.501 rs10202813 chr2:103019740 A/C cg20060108 chr2:102954350 IL1RL1 -0.44 -6.7 -0.34 9.12e-11 Blood protein levels; LUSC cis rs4663866 1.000 rs4663867 chr2:239159964 G/C cg16914508 chr2:239161102 PER2 0.68 7.14 0.36 5.87e-12 Irritable bowel syndrome; LUSC trans rs7939886 0.920 rs7107736 chr11:55987980 C/G cg03929089 chr4:120376271 NA 0.82 6.13 0.32 2.55e-9 Myopia (pathological); LUSC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg18305652 chr10:134549665 INPP5A 0.44 6.66 0.34 1.1e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 8.69 0.43 1.67e-16 Gut microbiome composition (summer); LUSC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg17376030 chr22:41985996 PMM1 -0.47 -5.84 -0.3 1.25e-8 Vitiligo; LUSC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg16325326 chr1:53192061 ZYG11B 0.82 14.09 0.61 1.07e-35 Monocyte count; LUSC cis rs1950500 0.509 rs12888965 chr14:24834291 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 0.53 8.14 0.41 7.9e-15 Height; LUSC cis rs921968 0.565 rs4674330 chr2:219595710 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.08 -0.48 4.89e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs61774743 0.636 rs1892423 chr1:41849340 A/C cg08462924 chr1:41848221 NA 0.47 7.93 0.4 3.33e-14 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg08470875 chr2:26401718 FAM59B -0.68 -9.27 -0.45 2.44e-18 Gut microbiome composition (summer); LUSC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg00343986 chr7:65444356 GUSB -0.42 -6.46 -0.33 3.7e-10 Aortic root size; LUSC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg25767906 chr1:53392781 SCP2 -0.36 -6.1 -0.32 2.89e-9 Monocyte count; LUSC cis rs9457247 0.515 rs1951459 chr6:167402536 G/A cg23791538 chr6:167370224 RNASET2 0.5 8.21 0.41 4.88e-15 Crohn's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg24603235 chr6:33588219 ITPR3 0.8 6.41 0.33 4.86e-10 Cognitive performance; LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC trans rs6982636 1.000 rs2980856 chr8:126476379 C/G cg13325919 chr3:181432053 SOX2;SOX2OT 0.35 6.69 0.34 9.62e-11 Lipid metabolism phenotypes; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg07832834 chr1:2457954 PANK4 -0.33 -6.03 -0.31 4.37e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs12900413 0.687 rs28465116 chr15:90310152 T/C cg24249390 chr15:90295951 MESP1 -0.37 -5.91 -0.31 8.6e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs11098499 0.954 rs13113483 chr4:120309039 C/T cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.7 0.34 8.68e-11 Lung cancer; LUSC cis rs921968 0.643 rs500317 chr2:219432953 G/C cg02176678 chr2:219576539 TTLL4 0.64 11.85 0.54 2.83e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs4478858 0.684 rs7528066 chr1:31749092 C/G cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs6460942 0.505 rs73055515 chr7:12328804 A/G cg06484146 chr7:12443880 VWDE -0.57 -5.94 -0.31 7.05e-9 Coronary artery disease; LUSC cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg25019033 chr10:957182 NA -0.56 -7.15 -0.36 5.35e-12 Eosinophil percentage of granulocytes; LUSC cis rs13096357 0.520 rs17080319 chr3:48732480 T/C cg00383909 chr3:49044727 WDR6 1.14 10.08 0.48 5.06e-21 Cognitive ability (multi-trait analysis); LUSC cis rs701145 0.938 rs355769 chr3:154042550 T/C cg17054900 chr3:154042577 DHX36 0.81 8.73 0.43 1.2e-16 Coronary artery disease; LUSC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg06026331 chr20:60912101 LAMA5 0.57 7.07 0.36 8.85e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg24011408 chr12:48396354 COL2A1 -0.39 -5.74 -0.3 2.18e-8 Glycated hemoglobin levels; LUSC cis rs7809950 0.678 rs2237660 chr7:106862963 T/A cg23024343 chr7:107201750 COG5 -0.66 -9.38 -0.46 1.03e-18 Coronary artery disease; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg24739457 chr1:205821442 NA 0.36 6.12 0.32 2.68e-9 Menarche (age at onset); LUSC cis rs17095355 1.000 rs7905306 chr10:111712902 C/T cg00817464 chr10:111662876 XPNPEP1 -0.64 -8.08 -0.4 1.16e-14 Biliary atresia; LUSC cis rs61931739 0.517 rs1486882 chr12:34025896 A/G cg06521331 chr12:34319734 NA -0.47 -7.68 -0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs67072384 0.901 rs11235585 chr11:72476007 G/A cg04827223 chr11:72435913 ARAP1 -0.8 -5.98 -0.31 5.58e-9 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs1878931 0.501 rs9635547 chr16:3416664 C/T cg21433313 chr16:3507492 NAT15 -0.37 -5.86 -0.31 1.09e-8 Body mass index (adult); LUSC trans rs10802346 0.545 rs10802345 chr1:246372834 C/T cg22732515 chr19:44031385 ETHE1 0.63 10.48 0.5 2.07e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs7617480 0.587 rs9311431 chr3:48848787 T/A cg07636037 chr3:49044803 WDR6 0.9 11.71 0.54 9.27e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg18240062 chr17:79603768 NPLOC4 0.72 13.38 0.59 5.65e-33 Eye color traits; LUSC cis rs4845570 1.000 rs17568246 chr1:151736456 A/G cg07092448 chr1:151763213 TDRKH -1.14 -11.46 -0.53 7.11e-26 Coronary artery disease; LUSC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg04511125 chr2:88470314 THNSL2 -0.44 -6.62 -0.34 1.41e-10 Response to metformin (IC50); LUSC cis rs10744422 0.925 rs2061098 chr12:123349410 T/C cg25930673 chr12:123319894 HIP1R -0.6 -5.96 -0.31 6.34e-9 Schizophrenia; LUSC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -7.31 -0.37 2.02e-12 Developmental language disorder (linguistic errors); LUSC cis rs4319547 0.585 rs10846792 chr12:122882374 T/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.43 -0.42 1.03e-15 Body mass index; LUSC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg03354898 chr7:1950403 MAD1L1 -0.32 -6.12 -0.32 2.66e-9 Schizophrenia; LUSC cis rs7264396 0.747 rs2425151 chr20:34394541 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.83 -0.43 6.1e-17 Total cholesterol levels; LUSC cis rs950776 0.518 rs12906284 chr15:78825105 C/T cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.44 6.45 0.33 3.93e-10 Breast cancer; LUSC cis rs4474465 1.000 rs966456 chr11:78168603 T/A cg27205649 chr11:78285834 NARS2 -0.52 -6.06 -0.31 3.77e-9 Alzheimer's disease (survival time); LUSC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg22834771 chr12:69754056 YEATS4 -0.5 -7.45 -0.38 8.09e-13 Blood protein levels; LUSC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg16339924 chr4:17578868 LAP3 0.56 8.6 0.43 3.21e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7527798 0.592 rs7539772 chr1:207833301 G/A cg09232269 chr1:207846808 CR1L -0.29 -6.15 -0.32 2.17e-9 Erythrocyte sedimentation rate; LUSC cis rs651907 0.640 rs771575 chr3:101619359 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.47 6.2 0.32 1.65e-9 Colorectal cancer; LUSC cis rs10782582 0.593 rs6673786 chr1:76149637 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.08 -0.36 8.69e-12 Daytime sleep phenotypes; LUSC cis rs934734 0.544 rs4671127 chr2:65562970 C/G cg08085232 chr2:65598271 SPRED2 -0.44 -6.87 -0.35 3.12e-11 Rheumatoid arthritis; LUSC cis rs983392 0.678 rs1426253 chr11:59981218 A/C cg24026212 chr11:59952134 MS4A6A -0.35 -6.07 -0.32 3.51e-9 Alzheimer's disease (late onset); LUSC cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg24397884 chr7:158709396 WDR60 -0.77 -12.27 -0.56 8.26e-29 Height; LUSC cis rs11583043 1.000 rs35445887 chr1:101523639 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 5.83 0.3 1.34e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg11218175 chr11:495084 RNH1 0.53 5.71 0.3 2.51e-8 Body mass index; LUSC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg04267008 chr7:1944627 MAD1L1 -0.54 -8.16 -0.41 6.68e-15 Bipolar disorder and schizophrenia; LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs1524927 0.566 rs12704876 chr7:96366342 C/T cg03808172 chr7:96339361 SHFM1 0.41 6.57 0.34 1.9e-10 Total body bone mineral density; LUSC cis rs6964587 0.934 rs4512319 chr7:91733829 G/A cg17063962 chr7:91808500 NA 0.54 8.16 0.41 6.98e-15 Breast cancer; LUSC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg20243544 chr17:37824526 PNMT 0.53 7.53 0.38 4.77e-13 Asthma; LUSC cis rs198426 0.506 rs11230767 chr11:61426932 G/A cg19838087 chr11:61442541 NA 0.3 5.99 0.31 5.47e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid); LUSC cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg00290607 chr11:67383545 NA 0.37 6.98 0.36 1.58e-11 Mean corpuscular volume; LUSC cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg13256891 chr4:100009986 ADH5 0.47 6.46 0.33 3.62e-10 Alcohol dependence; LUSC cis rs9768139 0.708 rs11769028 chr7:158113881 G/A cg06219351 chr7:158114137 PTPRN2 -0.54 -9.85 -0.47 2.89e-20 Calcium levels; LUSC trans rs7230711 1.000 rs11663585 chr18:48687098 G/A cg07422195 chr1:23894874 NA -0.6 -6.03 -0.31 4.24e-9 Immune response to anthrax vaccine; LUSC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18404041 chr3:52824283 ITIH1 -0.54 -10.3 -0.49 8.65e-22 Bipolar disorder; LUSC cis rs992157 0.710 rs12694432 chr2:219082330 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.81 0.39 7.71e-14 Colorectal cancer; LUSC cis rs7582180 0.652 rs11678158 chr2:100932297 T/C cg14675211 chr2:100938903 LONRF2 0.37 5.75 0.3 2.03e-8 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03769349 chr8:95565789 KIAA1429 0.49 6.94 0.36 2.09e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8180040 0.729 rs11720439 chr3:47347003 T/G cg27129171 chr3:47204927 SETD2 -0.69 -10.53 -0.5 1.41e-22 Colorectal cancer; LUSC cis rs7903847 0.619 rs10786336 chr10:99134953 A/C cg08345082 chr10:99160200 RRP12 -0.38 -7.76 -0.39 1.06e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg21770322 chr7:97807741 LMTK2 0.4 6.87 0.35 3.1e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs11190604 1.000 rs2489035 chr10:102319395 C/T cg07080220 chr10:102295463 HIF1AN 0.67 8.64 0.43 2.38e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.37 0.33 6.13e-10 Hip circumference adjusted for BMI; LUSC cis rs2742234 0.910 rs2503866 chr10:43646261 T/A cg02780029 chr10:43622663 RET -0.36 -6.87 -0.35 3.07e-11 Hirschsprung disease; LUSC cis rs644148 0.836 rs2686770 chr19:44998773 A/G cg15540054 chr19:45004280 ZNF180 -0.62 -9.22 -0.45 3.37e-18 Personality dimensions; LUSC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg13770153 chr20:60521292 NA -0.63 -8.55 -0.42 4.57e-16 Body mass index; LUSC cis rs4974559 0.895 rs28493051 chr4:1331030 A/C cg02980000 chr4:1222292 CTBP1 0.67 7.83 0.39 6.68e-14 Systolic blood pressure; LUSC trans rs61931739 0.534 rs1705757 chr12:34091637 A/G cg26384229 chr12:38710491 ALG10B 0.7 10.74 0.51 2.52e-23 Morning vs. evening chronotype; LUSC cis rs9650315 0.852 rs7830176 chr8:57172974 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.95 0.31 6.61e-9 Rheumatoid arthritis; LUSC cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg03684893 chr10:554711 DIP2C 0.36 6.4 0.33 5.3e-10 Psychosis in Alzheimer's disease; LUSC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg04155289 chr7:94953770 PON1 -0.34 -5.75 -0.3 2.02e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg13628971 chr7:2884303 GNA12 0.37 5.73 0.3 2.3e-8 Height; LUSC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg01652190 chr22:50026171 C22orf34 -0.3 -6.16 -0.32 2.1e-9 Monocyte count;Monocyte percentage of white cells; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg09549848 chr9:113800279 LPAR1 -0.49 -6.21 -0.32 1.53e-9 Cognitive function;Information processing speed; LUSC cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg11752832 chr7:134001865 SLC35B4 0.53 8.03 0.4 1.74e-14 Mean platelet volume; LUSC cis rs477692 0.905 rs485579 chr10:131425492 T/G cg05714579 chr10:131428358 MGMT 0.54 8.22 0.41 4.4e-15 Response to temozolomide; LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg15147215 chr3:52552868 STAB1 -0.34 -6.67 -0.34 1.06e-10 Bipolar disorder; LUSC cis rs7122539 0.603 rs508443 chr11:66509369 C/T cg24851651 chr11:66362959 CCS -0.55 -9.85 -0.47 2.85e-20 HIV-1 susceptibility; LUSC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg18240062 chr17:79603768 NPLOC4 0.79 15.24 0.64 3.35e-40 Eye color traits; LUSC cis rs7605827 0.930 rs3796002 chr2:15567649 T/C cg19274914 chr2:15703543 NA 0.47 8.94 0.44 2.79e-17 Educational attainment (years of education); LUSC trans rs61931739 0.534 rs4931783 chr12:34115322 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.51 0.42 5.94e-16 Morning vs. evening chronotype; LUSC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.25e-11 Tonsillectomy; LUSC cis rs11098499 0.863 rs6835635 chr4:120458867 A/G cg24375607 chr4:120327624 NA 0.71 10.81 0.51 1.5e-23 Corneal astigmatism; LUSC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg08847533 chr14:75593920 NEK9 -0.81 -13.69 -0.6 3.5e-34 Height; LUSC cis rs3806843 1.000 rs10057161 chr5:140156831 C/T cg26395211 chr5:140044315 WDR55 -0.38 -5.89 -0.31 9.53e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs936229 0.656 rs12898397 chr15:75130093 T/C cg14664628 chr15:75095509 CSK -0.77 -12.05 -0.55 5.36e-28 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs2736345 0.516 rs9657551 chr8:11398183 A/G cg21775007 chr8:11205619 TDH 0.42 5.91 0.31 8.35e-9 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs614226 0.938 rs787824 chr12:120924638 A/G cg27489772 chr12:121021490 NA -0.51 -6.6 -0.34 1.64e-10 Type 1 diabetes nephropathy; LUSC cis rs789859 0.869 rs1773225 chr3:194403578 A/G cg02072170 chr3:194406190 FAM43A 0.39 8.16 0.41 7e-15 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC trans rs7824557 0.628 rs3779891 chr8:11183505 G/A cg15556689 chr8:8085844 FLJ10661 0.45 6.69 0.34 9.44e-11 Retinal vascular caliber; LUSC cis rs9905704 0.881 rs2611774 chr17:56732304 G/A cg12560992 chr17:57184187 TRIM37 0.53 7.49 0.38 6.3e-13 Testicular germ cell tumor; LUSC cis rs7561273 0.586 rs6545302 chr2:24364557 G/T cg06627628 chr2:24431161 ITSN2 -0.55 -7.17 -0.37 4.85e-12 Quantitative traits; LUSC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.72 0.35 7.83e-11 Lung cancer; LUSC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg15145296 chr3:125709740 NA -0.56 -6.31 -0.33 9e-10 Blood pressure (smoking interaction); LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.49 5.96 0.31 6.44e-9 Renal function-related traits (BUN); LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg07507251 chr3:52567010 NT5DC2 0.31 6.12 0.32 2.64e-9 Bipolar disorder; LUSC cis rs12493885 0.818 rs73158489 chr3:153757862 C/T cg17054900 chr3:154042577 DHX36 -0.55 -6.01 -0.31 4.76e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.8e-10 Schizophrenia; LUSC trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg03929089 chr4:120376271 NA -0.95 -16.23 -0.66 4.32e-44 Coronary artery disease; LUSC cis rs11971779 0.616 rs6967932 chr7:139022381 C/T cg23387468 chr7:139079360 LUC7L2 0.42 6.28 0.33 1.04e-9 Diisocyanate-induced asthma; LUSC cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9815354 1.000 rs73081353 chr3:41906448 T/A cg03022575 chr3:42003672 ULK4 0.61 6.69 0.34 9.3e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs2274459 1.000 rs12189725 chr6:33703394 G/T cg06253072 chr6:33679850 C6orf125 0.5 5.67 0.3 3.03e-8 Obesity (extreme); LUSC cis rs9905704 0.723 rs71372848 chr17:56736598 G/C cg12560992 chr17:57184187 TRIM37 0.54 7.72 0.39 1.36e-13 Testicular germ cell tumor; LUSC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg06238570 chr21:40685208 BRWD1 0.52 7.92 0.4 3.58e-14 Cognitive function; LUSC cis rs7927592 0.913 rs7115374 chr11:68300076 G/T cg16797656 chr11:68205561 LRP5 0.38 6.25 0.32 1.27e-9 Total body bone mineral density; LUSC cis rs7830933 0.780 rs11986562 chr8:23609098 T/C cg04349084 chr8:23602677 NA 0.35 5.71 0.3 2.47e-8 Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist-to-hip ratio adjusted for body mass index;Waist circumference adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI in non-smokers; LUSC cis rs7937682 0.575 rs12808601 chr11:111776066 G/A cg22437258 chr11:111473054 SIK2 -0.43 -5.66 -0.3 3.21e-8 Primary sclerosing cholangitis; LUSC cis rs35883536 0.609 rs1577513 chr1:101044402 C/A cg09408571 chr1:101003634 GPR88 0.29 5.73 0.3 2.25e-8 Monocyte count; LUSC trans rs9747201 0.609 rs9303022 chr17:80170651 C/G cg07393940 chr7:158741817 NA 0.53 8.4 0.42 1.3e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg09849774 chr21:43526787 UMODL1;C21orf128 -0.42 -6.15 -0.32 2.17e-9 IgG glycosylation; LUSC cis rs11809207 1.000 rs11247867 chr1:26517891 C/T cg00147160 chr1:26503991 CNKSR1 0.41 6.77 0.35 5.87e-11 Height; LUSC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg13498757 chr1:152161927 NA 0.35 5.81 0.3 1.46e-8 Inflammatory skin disease; LUSC cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg11244672 chr19:19639970 YJEFN3 0.55 6.79 0.35 5.18e-11 Bipolar disorder; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg18765753 chr7:1198926 ZFAND2A -0.57 -10.16 -0.49 2.69e-21 Longevity;Endometriosis; LUSC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21582582 chr3:182698605 DCUN1D1 -0.46 -8.13 -0.41 8.35e-15 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg26516362 chr5:178986906 RUFY1 -0.52 -8.81 -0.43 6.96e-17 Lung cancer; LUSC trans rs8073060 0.544 rs225258 chr17:33956883 C/T cg19694781 chr19:47549865 TMEM160 -1.13 -18.04 -0.7 2.96e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg11645453 chr3:52864694 ITIH4 0.34 7.84 0.39 6.2e-14 Electroencephalogram traits; LUSC cis rs11690935 0.595 rs788166 chr2:172915489 G/C cg13550731 chr2:172543902 DYNC1I2 0.56 8.95 0.44 2.55e-17 Schizophrenia; LUSC trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg10645314 chr2:3704589 ALLC 0.46 7.4 0.38 1.09e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12478296 1.000 rs60533128 chr2:243028088 A/G cg06360820 chr2:242988706 NA -1.01 -10.5 -0.5 1.82e-22 Obesity-related traits; LUSC cis rs6987853 0.787 rs2923448 chr8:42406008 G/A cg09913449 chr8:42400586 C8orf40 0.53 9.22 0.45 3.48e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs1080500 1.000 rs1080500 chr3:53175017 C/T cg11645453 chr3:52864694 ITIH4 0.34 7.41 0.38 1.01e-12 Autism spectrum disorder or schizophrenia; LUSC trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.64e-10 Neuroticism; LUSC cis rs9814567 1.000 rs13089966 chr3:134279197 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.48 0.59 2.28e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3540 0.554 rs34650360 chr15:91059017 T/C cg22089800 chr15:90895588 ZNF774 -0.65 -9.83 -0.47 3.47e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg14668632 chr7:2872130 GNA12 -0.5 -7.11 -0.36 6.96e-12 Height; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg00628130 chr8:95908808 CCNE2 0.37 6.12 0.32 2.62e-9 Calcium levels; LUSC trans rs961253 0.556 rs6054138 chr20:6327700 G/A cg21095983 chr6:86352623 SYNCRIP 0.45 6.78 0.35 5.62e-11 Colorectal cancer; LUSC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg18357526 chr6:26021779 HIST1H4A 0.37 5.81 0.3 1.42e-8 Intelligence (multi-trait analysis); LUSC cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg25173405 chr17:45401733 C17orf57 0.36 5.72 0.3 2.35e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2439831 0.867 rs2278860 chr15:43659046 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -1.04 -13.0 -0.58 1.44e-31 Lung cancer in ever smokers; LUSC cis rs9925964 0.933 rs10871454 chr16:31048079 C/T cg02466173 chr16:30829666 NA 0.36 6.57 0.34 1.91e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4774899 0.932 rs1867641 chr15:57527722 A/G cg08128148 chr15:57256372 TCF12 -0.35 -5.69 -0.3 2.77e-8 Urinary tract infection frequency; LUSC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg08027265 chr7:2291960 NA -0.39 -6.28 -0.32 1.05e-9 Bipolar disorder and schizophrenia; LUSC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.13 0.45 6.62e-18 Height; LUSC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg13866156 chr1:1669148 SLC35E2 -0.53 -8.86 -0.44 4.9e-17 Body mass index; LUSC cis rs1595825 0.891 rs16823148 chr2:198584209 G/A cg00982548 chr2:198649783 BOLL -0.52 -6.77 -0.35 5.87e-11 Ulcerative colitis; LUSC cis rs6752107 0.782 rs12692254 chr2:234161211 A/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.71 11.98 0.55 9.49e-28 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4911259 0.552 rs13037833 chr20:31459562 C/T cg13636640 chr20:31349939 DNMT3B -0.81 -15.5 -0.65 3.37e-41 Inflammatory bowel disease; LUSC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg06713675 chr4:122721982 EXOSC9 -0.7 -12.04 -0.55 5.88e-28 Type 2 diabetes; LUSC cis rs8032315 0.965 rs8027450 chr15:91418394 C/T cg06330618 chr15:91428456 FES 0.28 5.65 0.3 3.5e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs8031584 0.678 rs35098644 chr15:31145440 A/G cg08109568 chr15:31115862 NA -0.73 -10.64 -0.5 5.71e-23 Huntington's disease progression; LUSC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg24829409 chr8:58192753 C8orf71 -0.61 -7.49 -0.38 6.09e-13 Developmental language disorder (linguistic errors); LUSC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg11843238 chr5:131593191 PDLIM4 0.46 7.8 0.39 8e-14 Acylcarnitine levels; LUSC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg09267113 chr7:98030324 BAIAP2L1 0.4 6.08 0.32 3.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4595586 0.546 rs2056159 chr12:39270417 C/G cg26384229 chr12:38710491 ALG10B 0.77 11.44 0.53 8.25e-26 Morning vs. evening chronotype; LUSC cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg07606381 chr6:8435919 SLC35B3 0.72 11.99 0.55 8.29e-28 Motion sickness; LUSC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg07424592 chr7:64974309 NA 0.67 5.97 0.31 6.18e-9 Diabetic kidney disease; LUSC cis rs9788721 0.934 rs16969968 chr15:78882925 G/A cg06917634 chr15:78832804 PSMA4 -0.43 -5.94 -0.31 7.33e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs17213078 0.510 rs17032713 chr2:106886839 T/C cg00318621 chr2:106887213 NA -0.37 -6.84 -0.35 3.76e-11 Facial morphology (factor 23); LUSC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.37 5.96 0.31 6.51e-9 Menopause (age at onset); LUSC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg00944433 chr1:107599041 PRMT6 0.36 6.7 0.34 8.99e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7223966 1.000 rs8078462 chr17:61857937 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.96 0.36 1.86e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9399135 0.967 rs7763836 chr6:135362378 T/C cg22676075 chr6:135203613 NA 0.46 7.24 0.37 3.06e-12 Red blood cell count; LUSC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg02463440 chr8:22132932 PIWIL2 0.41 7.43 0.38 9.43e-13 Hypertriglyceridemia; LUSC trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.62 -0.38 2.63e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs7296418 0.580 rs78455769 chr12:123856443 G/A cg13010344 chr12:123464640 ARL6IP4 -0.51 -8.13 -0.41 8.2e-15 Platelet count; LUSC cis rs7512552 0.809 rs698923 chr1:150379159 G/A cg15654264 chr1:150340011 RPRD2 0.66 11.01 0.52 2.84e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7584330 0.666 rs72620817 chr2:238353661 C/T cg14458575 chr2:238380390 NA 0.85 15.07 0.64 1.61e-39 Prostate cancer; LUSC cis rs10186029 0.680 rs10179508 chr2:213978526 C/T cg08319019 chr2:214017104 IKZF2 -0.57 -8.2 -0.41 5.25e-15 Systemic sclerosis; LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg11645453 chr3:52864694 ITIH4 0.34 7.7 0.39 1.59e-13 Bipolar disorder; LUSC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.37 -0.42 1.56e-15 Mean platelet volume; LUSC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs9690778 chr7:91735299 A/G cg22117172 chr7:91764530 CYP51A1 0.33 5.84 0.3 1.24e-8 Breast cancer; LUSC cis rs6980507 0.523 rs2974293 chr8:42369455 C/T cg09913449 chr8:42400586 C8orf40 -0.45 -7.89 -0.4 4.42e-14 Glycated hemoglobin levels; LUSC cis rs1215050 0.791 rs984940 chr4:98811756 T/A cg05340658 chr4:99064831 C4orf37 0.44 6.88 0.35 3.05e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2688608 0.620 rs7098444 chr10:75580042 C/T cg23231163 chr10:75533350 FUT11 -0.43 -6.85 -0.35 3.62e-11 Inflammatory bowel disease; LUSC trans rs10432489 0.708 rs10178270 chr2:181773395 G/C cg16818443 chr4:2965195 GRK4;NOP14 0.82 6.01 0.31 4.74e-9 QT interval; LUSC cis rs1448094 0.935 rs11117119 chr12:86336432 A/T cg00310523 chr12:86230176 RASSF9 0.39 6.95 0.36 1.9e-11 Major depressive disorder; LUSC cis rs79349575 0.783 rs61576918 chr17:46985593 A/C cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs7202877 0.656 rs6564245 chr16:75308899 A/G cg03315344 chr16:75512273 CHST6 -0.46 -6.53 -0.34 2.46e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs6087771 0.851 rs6087775 chr20:30325765 G/A cg13852791 chr20:30311386 BCL2L1 0.93 14.15 0.61 6.1e-36 Subcortical brain region volumes;Putamen volume; LUSC cis rs9952991 0.941 rs2542149 chr18:12779018 G/A cg23544223 chr18:12777786 NA 0.59 6.27 0.32 1.15e-9 Inflammatory skin disease; LUSC trans rs11098499 0.954 rs6849561 chr4:120409694 C/G cg19731845 chr4:166199412 KLHL2;GK3P -0.47 -6.21 -0.32 1.53e-9 Corneal astigmatism; LUSC cis rs864537 0.618 rs2988277 chr1:167431352 A/G cg22356347 chr1:167427500 CD247 0.33 7.84 0.39 6.27e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.41 0.33 4.84e-10 Intelligence (multi-trait analysis); LUSC trans rs6952808 0.792 rs2056480 chr7:1954301 A/G cg04565464 chr8:145669602 NFKBIL2 -0.37 -6.02 -0.31 4.56e-9 Bipolar disorder and schizophrenia; LUSC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.75 13.73 0.6 2.57e-34 Intelligence (multi-trait analysis); LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg25151919 chr3:44754333 ZNF502 -0.38 -6.1 -0.32 2.92e-9 Depressive symptoms; LUSC trans rs7937682 0.889 rs541198 chr11:111475340 A/G cg18187862 chr3:45730750 SACM1L 0.52 6.83 0.35 4e-11 Primary sclerosing cholangitis; LUSC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg18402987 chr7:1209562 NA 0.73 8.42 0.42 1.13e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6489882 0.703 rs2285934 chr12:113351520 A/C cg20102336 chr12:113376681 OAS3 -0.38 -5.88 -0.31 9.82e-9 Chronic lymphocytic leukemia; LUSC trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.68 -0.39 1.83e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs11758351 1.000 rs2143346 chr6:26198449 C/G cg23601095 chr6:26197514 HIST1H3D -0.71 -7.31 -0.37 1.95e-12 Gout;Renal underexcretion gout; LUSC cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.58 -11.42 -0.53 1.04e-25 Monocyte percentage of white cells; LUSC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg24011408 chr12:48396354 COL2A1 0.41 5.87 0.31 1.03e-8 Glycated hemoglobin levels; LUSC cis rs6433857 0.505 rs7561255 chr2:181369216 A/G cg23363182 chr2:181467187 NA -0.45 -7.22 -0.37 3.5e-12 Body mass index; LUSC cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg24812749 chr6:127587940 RNF146 0.92 13.97 0.61 3.03e-35 Breast cancer; LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg08219700 chr8:58056026 NA 0.66 7.82 0.39 7.08e-14 Developmental language disorder (linguistic errors); LUSC cis rs868036 0.609 rs13329413 chr15:68097126 C/T cg08079166 chr15:68083412 MAP2K5 0.49 8.34 0.42 2e-15 Restless legs syndrome; LUSC cis rs9323205 0.798 rs11157805 chr14:51658390 C/G cg23942311 chr14:51606299 NA 0.36 7.38 0.37 1.26e-12 Cancer; LUSC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg03526776 chr6:41159608 TREML2 0.33 6.12 0.32 2.67e-9 Alzheimer's disease (late onset); LUSC trans rs7833787 0.644 rs4921965 chr8:18679866 C/T cg25885280 chr11:70760166 SHANK2 -0.24 -6.13 -0.32 2.46e-9 Obesity-related traits; LUSC cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg06636001 chr8:8085503 FLJ10661 0.71 10.27 0.49 1.06e-21 Red cell distribution width; LUSC cis rs16895831 0.531 rs12195803 chr6:42527571 G/A cg10605015 chr6:42532144 UBR2 -0.5 -6.08 -0.32 3.3e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11890956 chr21:40555474 PSMG1 -0.74 -11.55 -0.53 3.37e-26 Menarche (age at onset); LUSC trans rs9473924 1.000 rs9463656 chr6:50859655 A/G cg22375689 chr19:34175036 CHST8 0.38 6.14 0.32 2.35e-9 Body mass index; LUSC cis rs9325144 0.723 rs11169519 chr12:39177441 G/A cg26384229 chr12:38710491 ALG10B -0.6 -9.31 -0.45 1.73e-18 Morning vs. evening chronotype; LUSC cis rs9395066 0.545 rs3799976 chr6:44835622 T/G cg25276700 chr6:44698697 NA 0.3 6.05 0.31 3.87e-9 Height; LUSC trans rs3960554 0.674 rs112742093 chr7:75800597 T/C cg19862616 chr7:65841803 NCRNA00174 0.9 10.15 0.49 2.85e-21 Eotaxin levels; LUSC cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg12310025 chr6:25882481 NA -0.5 -8.99 -0.44 1.82e-17 Blood metabolite levels; LUSC cis rs12042938 0.600 rs1865225 chr1:231763004 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.45 -6.55 -0.34 2.15e-10 Neuranatomic and neurocognitive phenotypes; LUSC cis rs10876993 0.928 rs774890 chr12:58068388 C/T cg18357645 chr12:58087776 OS9 0.54 8.3 0.41 2.58e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs6964587 0.967 rs12671991 chr7:91559481 T/C cg01689657 chr7:91764605 CYP51A1 -0.34 -6.06 -0.31 3.58e-9 Breast cancer; LUSC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 14.11 0.61 8.82e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs422249 0.512 rs174583 chr11:61609750 A/G cg19610905 chr11:61596333 FADS2 0.51 7.97 0.4 2.45e-14 Trans fatty acid levels; LUSC cis rs61931739 0.517 rs7958755 chr12:34294699 T/C cg06521331 chr12:34319734 NA -0.47 -7.82 -0.39 7.04e-14 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14970666 chr5:2038989 NA 0.43 6.77 0.35 5.87e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs7208859 0.524 rs59923796 chr17:29064919 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.74 -0.39 1.22e-13 Neuroticism; LUSC cis rs7829975 0.539 rs940031 chr8:8546848 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.48 -0.33 3.39e-10 Mood instability; LUSC cis rs2273669 0.667 rs2145763 chr6:109306963 C/A cg05315195 chr6:109294784 ARMC2 -0.56 -6.21 -0.32 1.54e-9 Prostate cancer; LUSC cis rs11098499 0.739 rs2203039 chr4:120132347 T/C cg24375607 chr4:120327624 NA -0.69 -10.97 -0.51 3.92e-24 Corneal astigmatism; LUSC cis rs5167 0.533 rs11083755 chr19:45490065 C/T cg25746394 chr19:45450501 APOC2 0.32 6.07 0.32 3.55e-9 Blood protein levels; LUSC cis rs2637266 1.000 rs7081214 chr10:78361134 G/A cg18941641 chr10:78392320 NA 0.4 7.46 0.38 7.78e-13 Pulmonary function; LUSC cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg04362960 chr10:104952993 NT5C2 -0.62 -9.5 -0.46 4.19e-19 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4642101 0.561 rs9812144 chr3:12805910 G/A cg05775895 chr3:12838266 CAND2 0.48 7.42 0.38 9.9e-13 QRS complex (12-leadsum); LUSC cis rs35995292 0.534 rs917322 chr7:38943165 A/T cg19327137 chr7:38886074 VPS41 -0.54 -10.15 -0.49 2.75e-21 Subjective well-being (multi-trait analysis); LUSC cis rs2120019 0.507 rs4886642 chr15:75228846 T/C cg09165964 chr15:75287851 SCAMP5 -0.97 -12.02 -0.55 6.78e-28 Blood trace element (Zn levels); LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg23758822 chr17:41437982 NA 1.07 20.77 0.75 4.02e-62 Menopause (age at onset); LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg07167872 chr1:205819463 PM20D1 0.54 9.22 0.45 3.45e-18 Menarche (age at onset); LUSC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg20307385 chr11:47447363 PSMC3 -0.42 -5.7 -0.3 2.61e-8 Subjective well-being; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03508908 chr6:91005117 BACH2 -0.48 -6.39 -0.33 5.59e-10 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg00431813 chr7:1051703 C7orf50 -0.39 -6.11 -0.32 2.72e-9 Longevity;Endometriosis; LUSC cis rs13223928 0.621 rs4722440 chr7:3155901 C/T cg19214707 chr7:3157722 NA 0.42 8.44 0.42 9.95e-16 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs11608355 0.521 rs6606703 chr12:109813665 C/T cg19025524 chr12:109796872 NA -0.41 -7.73 -0.39 1.25e-13 Neuroticism; LUSC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg22907277 chr7:1156413 C7orf50 0.71 7.56 0.38 3.84e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs868036 0.681 rs4548812 chr15:68060552 G/A cg27219399 chr15:67835830 MAP2K5 0.35 5.76 0.3 1.91e-8 Restless legs syndrome; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs11785400 0.762 rs1137522 chr8:143739020 A/C cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs2274273 0.840 rs2009291 chr14:55838230 A/C cg04306507 chr14:55594613 LGALS3 -0.57 -13.71 -0.6 3.04e-34 Protein biomarker; LUSC cis rs4594175 0.886 rs11157801 chr14:51622918 C/T cg23942311 chr14:51606299 NA 0.32 6.09 0.32 3.11e-9 Cancer; LUSC cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.07 0.48 5.08e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6961069 0.722 rs13438282 chr7:80262224 C/T cg04458919 chr7:80252533 CD36 0.37 6.66 0.34 1.1e-10 Platelet count; LUSC cis rs2070433 0.539 rs2839314 chr21:47961067 A/G cg12379764 chr21:47803548 PCNT 0.79 12.07 0.55 4.46e-28 Lymphocyte counts; LUSC cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg13319975 chr6:146136371 FBXO30 0.4 6.08 0.32 3.33e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs6429082 0.702 rs7532018 chr1:235706290 C/T cg26050004 chr1:235667680 B3GALNT2 -0.46 -6.21 -0.32 1.6e-9 Adiposity; LUSC cis rs11098499 0.863 rs11098531 chr4:120465001 G/A cg09307838 chr4:120376055 NA 0.76 11.04 0.52 2.31e-24 Corneal astigmatism; LUSC trans rs13314892 1.000 rs13314892 chr3:69795052 A/G cg25117505 chr11:66313529 ZDHHC24;ACTN3 0.44 6.2 0.32 1.67e-9 QRS complex (12-leadsum); LUSC trans rs804280 0.509 rs10109241 chr8:11784985 A/T cg15556689 chr8:8085844 FLJ10661 0.57 8.52 0.42 5.57e-16 Myopia (pathological); LUSC cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.89 0.35 2.71e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12286929 0.609 rs12417740 chr11:115098436 A/G cg04055981 chr11:115044050 NA -0.36 -6.39 -0.33 5.63e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg06634786 chr22:41940651 POLR3H 0.49 5.72 0.3 2.34e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1044826 0.642 rs4607068 chr3:139162994 A/G cg00490450 chr3:139108681 COPB2 0.49 7.74 0.39 1.18e-13 Obesity-related traits; LUSC cis rs3126085 0.867 rs36033453 chr1:152221226 T/G cg26876637 chr1:152193138 HRNR -0.46 -6.34 -0.33 7.49e-10 Atopic dermatitis; LUSC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18404041 chr3:52824283 ITIH1 -0.47 -8.6 -0.43 3.23e-16 Bipolar disorder; LUSC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -7.13 -0.36 6.2e-12 Breast cancer; LUSC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg19592336 chr6:28129416 ZNF389 0.41 5.7 0.3 2.65e-8 Parkinson's disease; LUSC cis rs2292884 0.505 rs11889660 chr2:238438395 C/T cg14458575 chr2:238380390 NA 0.55 6.49 0.33 3.15e-10 Prostate cancer; LUSC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.28 0.59 1.28e-32 Hip circumference adjusted for BMI; LUSC trans rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.74 -13.42 -0.59 3.84e-33 Brugada syndrome; LUSC trans rs800082 0.505 rs920148 chr3:144246677 A/C cg24215973 chr2:240111563 HDAC4 0.46 7.02 0.36 1.28e-11 Smoking behavior; LUSC cis rs11971779 0.648 rs6467849 chr7:139080512 C/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg23887609 chr12:130822674 PIWIL1 0.47 6.97 0.36 1.67e-11 Menopause (age at onset); LUSC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs67460515 0.500 rs1868105 chr3:160645335 A/G cg03342759 chr3:160939853 NMD3 -0.47 -6.09 -0.32 3.05e-9 Parkinson's disease; LUSC cis rs7647973 0.710 rs6446284 chr3:49616997 A/G cg13072238 chr3:49761600 GMPPB -0.69 -8.19 -0.41 5.44e-15 Menarche (age at onset); LUSC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg04352962 chr1:209979756 IRF6 0.54 6.19 0.32 1.73e-9 Cleft lip with or without cleft palate; LUSC trans rs8023715 1.000 rs34169613 chr15:97613156 C/T cg09939392 chr16:90068365 NA 0.52 6.0 0.31 5.09e-9 Systemic lupus erythematosus; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg01802117 chr1:53393560 SCP2 -0.41 -6.74 -0.35 6.84e-11 Monocyte count; LUSC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg25019033 chr10:957182 NA -0.51 -6.52 -0.34 2.67e-10 Eosinophil percentage of granulocytes; LUSC cis rs921665 0.680 rs7571242 chr2:3199025 A/G cg02624386 chr2:3182749 NA 0.59 6.41 0.33 4.82e-10 World class endurance athleticism; LUSC trans rs9747201 1.000 rs8082212 chr17:80175100 G/C cg07393940 chr7:158741817 NA 0.51 8.04 0.4 1.56e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg08736216 chr1:53307985 ZYG11A -0.29 -5.99 -0.31 5.41e-9 Monocyte count; LUSC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.39 0.37 1.22e-12 Bipolar disorder; LUSC cis rs4072705 0.586 rs7855247 chr9:127246644 T/C cg13476313 chr9:127244764 NR5A1 -0.31 -6.04 -0.31 4.13e-9 Menarche (age at onset); LUSC cis rs1003719 0.788 rs13050757 chr21:38465345 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs524023 0.629 rs480617 chr11:64478320 C/T cg19131476 chr11:64387923 NRXN2 -0.36 -8.52 -0.42 5.45e-16 Urate levels in obese individuals; LUSC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.78 0.43 8.4e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg12257692 chr3:49977190 RBM6 -0.24 -6.63 -0.34 1.38e-10 Intelligence (multi-trait analysis); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03614189 chr8:82598326 IMPA1 -0.45 -6.1 -0.32 2.87e-9 Hepatitis; LUSC cis rs11711311 0.955 rs10934247 chr3:113534941 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.65 0.34 1.19e-10 IgG glycosylation; LUSC cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg17845761 chr1:175162550 KIAA0040 -0.32 -6.15 -0.32 2.19e-9 Alcohol dependence; LUSC cis rs7681440 0.845 rs6843084 chr4:90766230 T/C cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs11792861 0.926 rs1051474 chr9:111881856 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.66 0.43 1.98e-16 Menarche (age at onset); LUSC cis rs61931739 0.500 rs11052994 chr12:34065843 C/T cg06521331 chr12:34319734 NA -0.48 -7.69 -0.39 1.65e-13 Morning vs. evening chronotype; LUSC cis rs11098499 0.863 rs12502389 chr4:120454191 A/G cg24375607 chr4:120327624 NA 0.76 11.23 0.52 4.89e-25 Corneal astigmatism; LUSC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg18876405 chr7:65276391 NA -0.5 -8.04 -0.4 1.61e-14 Aortic root size; LUSC cis rs4700695 0.841 rs152996 chr5:65256506 A/G cg21114390 chr5:65439923 SFRS12 0.49 5.64 0.3 3.56e-8 Facial morphology (factor 19); LUSC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg18876405 chr7:65276391 NA 0.7 12.65 0.57 3.19e-30 Aortic root size; LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg02353165 chr6:42928485 GNMT 0.66 11.14 0.52 1e-24 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs5769765 0.954 rs5770707 chr22:50244533 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.59 -0.34 1.71e-10 Schizophrenia; LUSC cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg24397884 chr7:158709396 WDR60 -0.76 -11.83 -0.54 3.22e-27 Height; LUSC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg04944784 chr2:26401820 FAM59B -0.68 -9.46 -0.46 5.58e-19 Gut microbiome composition (summer); LUSC cis rs11971779 0.680 rs12154842 chr7:139078484 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs9790314 0.580 rs960212 chr3:161047974 C/T cg03342759 chr3:160939853 NMD3 -0.42 -6.38 -0.33 6.08e-10 Morning vs. evening chronotype; LUSC trans rs9951602 0.512 rs9946138 chr18:76654608 A/G cg02800362 chr5:177631904 HNRNPAB 0.88 13.05 0.58 9.85e-32 Obesity-related traits; LUSC cis rs6469656 0.730 rs1529945 chr8:117660112 C/T cg24004040 chr8:117650383 NA -0.42 -6.26 -0.32 1.16e-9 Colorectal cancer; LUSC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg09835421 chr16:68378352 PRMT7 -0.53 -6.16 -0.32 2.08e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.34 -6.22 -0.32 1.52e-9 IgG glycosylation; LUSC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg03264133 chr6:25882463 NA -0.47 -7.93 -0.4 3.43e-14 Intelligence (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19596435 chr1:11741483 MAD2L2 -0.42 -6.7 -0.34 8.77e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6546537 0.714 rs17036759 chr2:69767029 C/T cg10773587 chr2:69614142 GFPT1 -0.61 -10.22 -0.49 1.6e-21 Serum thyroid-stimulating hormone levels; LUSC cis rs35146811 0.735 rs1636975 chr7:99812089 A/G cg19116668 chr7:99932089 PMS2L1 0.35 6.12 0.32 2.68e-9 Coronary artery disease; LUSC cis rs9326248 0.581 rs10502222 chr11:116833730 C/T cg20608306 chr11:116969690 SIK3 0.39 7.29 0.37 2.27e-12 Blood protein levels; LUSC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg22862634 chr11:62369728 EML3;MTA2 0.57 9.09 0.45 9.27e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg27535305 chr1:53392650 SCP2 -0.4 -7.57 -0.38 3.57e-13 Monocyte count; LUSC cis rs1267303 0.642 rs7542296 chr1:46998009 A/G cg25110126 chr1:46999211 NA 0.73 10.57 0.5 1.04e-22 Monobrow; LUSC cis rs4494114 0.967 rs6696437 chr1:39348165 G/A cg25970120 chr1:39325951 RRAGC -0.4 -6.2 -0.32 1.7e-9 Blood protein levels; LUSC cis rs12210905 0.688 rs12196452 chr6:27344415 A/T cg08851530 chr6:28072375 NA 0.9 5.84 0.3 1.21e-8 Hip circumference adjusted for BMI; LUSC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg04155289 chr7:94953770 PON1 -0.33 -5.69 -0.3 2.78e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs713587 0.563 rs2384057 chr2:25100167 C/G cg04586622 chr2:25135609 ADCY3 0.37 7.51 0.38 5.56e-13 Body mass index in non-asthmatics; LUSC cis rs3820928 0.618 rs2141828 chr2:227922470 T/C cg11843606 chr2:227700838 RHBDD1 -0.52 -6.92 -0.35 2.33e-11 Pulmonary function; LUSC cis rs9325144 0.600 rs1817648 chr12:38733424 C/T cg10518543 chr12:38710700 ALG10B -0.4 -5.65 -0.3 3.43e-8 Morning vs. evening chronotype; LUSC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg06022373 chr22:39101656 GTPBP1 0.78 12.16 0.55 2.1e-28 Menopause (age at onset); LUSC cis rs11792861 0.926 rs59904140 chr9:111910051 C/T cg05043794 chr9:111880884 C9orf5 -0.34 -7.32 -0.37 1.91e-12 Menarche (age at onset); LUSC cis rs4144743 0.528 rs2292866 chr17:45356782 T/C cg18085866 chr17:45331354 ITGB3 -0.78 -6.68 -0.34 9.76e-11 Body mass index; LUSC cis rs6121246 0.909 rs1994251 chr20:30287328 T/G cg13852791 chr20:30311386 BCL2L1 0.89 11.95 0.55 1.2e-27 Mean corpuscular hemoglobin; LUSC trans rs4665809 0.878 rs6720312 chr2:26364934 A/G cg19249749 chr1:223853145 CAPN8 0.54 6.59 0.34 1.72e-10 Gut microbiome composition (summer); LUSC cis rs7589342 0.839 rs10192144 chr2:106439854 A/G cg14210321 chr2:106509881 NCK2 -0.53 -7.96 -0.4 2.69e-14 Addiction; LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg13047869 chr3:10149882 C3orf24 0.6 8.52 0.42 5.73e-16 Alzheimer's disease; LUSC cis rs4853525 0.884 rs34303278 chr2:191731470 G/C cg11845111 chr2:191398756 TMEM194B -0.41 -5.97 -0.31 6.12e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg01416388 chr22:39784598 NA 0.42 7.14 0.36 5.98e-12 Intelligence (multi-trait analysis); LUSC cis rs4077515 0.967 rs3812558 chr9:139269135 A/G cg14169450 chr9:139327907 INPP5E 0.4 6.87 0.35 3.24e-11 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9902453 0.904 rs8071742 chr17:28361669 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg03264133 chr6:25882463 NA -0.6 -10.11 -0.48 3.86e-21 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs4142299 chr6:135377186 G/T cg22676075 chr6:135203613 NA 0.46 7.19 0.37 4.41e-12 Red blood cell count; LUSC cis rs614226 1.000 rs580016 chr12:120933977 T/C cg01236616 chr12:121019343 POP5 -1.24 -18.79 -0.72 3.08e-54 Type 1 diabetes nephropathy; LUSC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg22166914 chr1:53195759 ZYG11B 0.68 11.69 0.54 1.08e-26 Monocyte count; LUSC cis rs2386661 0.547 rs72781996 chr10:5646485 C/G cg17085576 chr10:5658249 NA -0.43 -6.3 -0.33 9.3e-10 Breast cancer; LUSC cis rs1448094 0.842 rs7978562 chr12:86451478 A/G cg02569458 chr12:86230093 RASSF9 0.36 5.79 0.3 1.66e-8 Major depressive disorder; LUSC cis rs8064299 0.574 rs1879455 chr17:72774738 C/G cg25054828 chr17:72772726 NAT9;TMEM104 0.91 17.46 0.69 5.81e-49 Monocyte count; LUSC cis rs782590 0.522 rs12329050 chr2:55894428 G/A cg18811423 chr2:55921094 PNPT1 -0.67 -9.92 -0.48 1.73e-20 Metabolic syndrome; LUSC cis rs708547 0.624 rs1277284 chr4:57855361 T/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.83 -0.3 1.29e-8 Response to bleomycin (chromatid breaks); LUSC trans rs12579753 0.956 rs34747993 chr12:82217777 C/T cg07923666 chr12:49932857 KCNH3 -0.51 -6.3 -0.33 9.31e-10 Resting heart rate; LUSC cis rs9467160 0.871 rs13191455 chr6:24448459 T/C cg20631270 chr6:24437470 GPLD1 0.45 5.98 0.31 5.83e-9 Liver enzyme levels; LUSC cis rs7824557 0.547 rs2409745 chr8:11076635 G/T cg27411982 chr8:10470053 RP1L1 0.39 6.0 0.31 5.18e-9 Retinal vascular caliber; LUSC cis rs231513 0.954 rs231494 chr17:41976928 G/C cg26893861 chr17:41843967 DUSP3 -0.51 -6.06 -0.31 3.74e-9 Cognitive function; LUSC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg26314531 chr2:26401878 FAM59B -0.68 -9.08 -0.44 9.58e-18 Gut microbiome composition (summer); LUSC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg23277830 chr1:3704460 LRRC47 0.35 6.66 0.34 1.11e-10 Red cell distribution width; LUSC trans rs2727020 0.576 rs12293522 chr11:49558425 T/A cg15704280 chr7:45808275 SEPT13 -1.1 -22.29 -0.77 4.45e-68 Coronary artery disease; LUSC cis rs3087591 0.887 rs2905796 chr17:29537586 G/A cg24425628 chr17:29625626 OMG;NF1 0.58 8.32 0.41 2.31e-15 Hip circumference; LUSC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.75 11.11 0.52 1.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10788674 chr12:133214645 POLE -0.69 -6.05 -0.31 3.86e-9 Cognitive performance; LUSC cis rs7605827 0.930 rs11903302 chr2:15706286 C/T cg19274914 chr2:15703543 NA 0.47 8.8 0.43 7.28e-17 Educational attainment (years of education); LUSC cis rs11785400 1.000 rs4297023 chr8:143733307 C/A cg24634471 chr8:143751801 JRK 0.59 8.99 0.44 1.82e-17 Schizophrenia; LUSC cis rs11785400 0.793 rs9774627 chr8:143731267 G/A cg10596483 chr8:143751796 JRK 0.53 7.59 0.38 3.17e-13 Schizophrenia; LUSC cis rs6964587 0.967 rs55801687 chr7:91762629 C/A cg17063962 chr7:91808500 NA 0.61 9.61 0.47 1.78e-19 Breast cancer; LUSC cis rs4242434 0.699 rs878051 chr8:22483836 T/C cg03733263 chr8:22462867 KIAA1967 0.76 12.36 0.56 3.78e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC trans rs11039798 1.000 rs11530232 chr11:48622376 C/T cg15704280 chr7:45808275 SEPT13 0.74 6.33 0.33 7.95e-10 Axial length; LUSC cis rs16949788 1.000 rs10468036 chr15:66710276 C/T cg08120210 chr15:66682733 MAP2K1 -0.6 -5.97 -0.31 6.22e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs644799 1.000 rs473155 chr11:95596873 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.88 14.79 0.63 1.97e-38 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg18538332 chr22:24372958 LOC391322 -0.4 -7.32 -0.37 1.83e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2235649 0.666 rs2076429 chr16:1817935 A/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 0.49 6.31 0.33 8.67e-10 Blood metabolite levels; LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg08280861 chr8:58055591 NA 0.54 5.66 0.3 3.23e-8 Developmental language disorder (linguistic errors); LUSC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg11941060 chr3:133502564 NA -0.48 -7.41 -0.38 1.04e-12 Iron status biomarkers; LUSC cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg24812749 chr6:127587940 RNF146 0.83 10.99 0.52 3.51e-24 Breast cancer; LUSC cis rs3008870 1.000 rs12132068 chr1:67451924 G/T cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.14 -0.64 8.9e-40 Lymphocyte percentage of white cells; LUSC cis rs1371867 0.817 rs1660314 chr8:101332953 C/T cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs4888262 0.508 rs4887779 chr16:74647795 A/G cg01733217 chr16:74700730 RFWD3 -0.79 -13.24 -0.59 1.87e-32 Testicular germ cell tumor; LUSC cis rs10750766 1 rs10750766 chr11:65473798 C/A cg24147428 chr11:65409760 SIPA1 0.39 6.2 0.32 1.66e-9 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg05234568 chr11:5960015 NA 0.63 9.82 0.47 3.7e-20 DNA methylation (variation); LUSC trans rs9929218 0.954 rs35794312 chr16:68827785 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -10.81 -0.51 1.44e-23 Colorectal cancer; LUSC cis rs921665 0.831 rs921666 chr2:3192141 G/C cg16434511 chr2:3151078 NA -0.63 -6.83 -0.35 3.92e-11 World class endurance athleticism; LUSC cis rs796825 0.530 rs34829073 chr3:119943371 C/T cg21790991 chr3:120137480 FSTL1 -0.33 -5.83 -0.3 1.32e-8 HIV-1 susceptibility; LUSC cis rs751728 1.000 rs4342423 chr6:33732679 C/T cg25922239 chr6:33757077 LEMD2 0.52 7.63 0.39 2.46e-13 Crohn's disease; LUSC trans rs853679 0.546 rs34295134 chr6:27828151 T/A cg06606381 chr12:133084897 FBRSL1 -0.77 -7.55 -0.38 4.28e-13 Depression; LUSC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg06713675 chr4:122721982 EXOSC9 -0.47 -8.24 -0.41 3.92e-15 Type 2 diabetes; LUSC cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg22455342 chr2:225449267 CUL3 0.77 10.47 0.5 2.27e-22 IgE levels in asthmatics (D.p. specific); LUSC cis rs12711979 0.509 rs12711972 chr2:3823786 T/C cg17052675 chr2:3827356 NA -0.84 -20.22 -0.74 6.49e-60 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg06634786 chr22:41940651 POLR3H -0.53 -6.1 -0.32 3e-9 Vitiligo; LUSC cis rs380904 0.552 rs10099003 chr8:144645460 C/T cg13399544 chr8:144649678 C8orf73 -0.46 -7.59 -0.38 3.25e-13 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs3733585 0.725 rs10939636 chr4:9972640 T/G cg26043149 chr18:55253948 FECH -0.46 -7.06 -0.36 9.81e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2760061 0.598 rs849904 chr1:228137145 G/C cg02753203 chr1:228287806 NA -0.65 -11.04 -0.52 2.33e-24 Diastolic blood pressure; LUSC cis rs11229555 0.645 rs7116847 chr11:58178478 C/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7202877 0.572 rs4888371 chr16:75308781 G/A cg04384234 chr16:75411784 CFDP1 -0.66 -9.62 -0.47 1.71e-19 Type 2 diabetes;Type 1 diabetes; LUSC cis rs4900538 0.855 rs60215817 chr14:102873886 A/G cg18135206 chr14:102964638 TECPR2 -1.0 -19.18 -0.72 8.48e-56 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2832077 0.943 rs4816332 chr21:30201706 T/C cg24692254 chr21:30365293 RNF160 -0.57 -7.14 -0.36 6.03e-12 Cognitive test performance; LUSC trans rs853679 0.607 rs13199906 chr6:27834139 C/G cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.13e-9 Depression; LUSC cis rs7615952 0.546 rs111812401 chr3:125361495 G/A cg05084668 chr3:125655381 ALG1L -0.42 -5.66 -0.3 3.33e-8 Blood pressure (smoking interaction); LUSC cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg22467129 chr15:76604101 ETFA -0.42 -6.66 -0.34 1.15e-10 Blood metabolite levels; LUSC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.96e-13 Obesity-related traits; LUSC cis rs9522267 0.535 rs9515454 chr13:112236885 A/G cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 2.99e-8 Hepatitis; LUSC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg00343986 chr7:65444356 GUSB 0.4 5.84 0.3 1.23e-8 Aortic root size; LUSC cis rs9875589 0.509 rs2129888 chr3:14013826 A/T cg19554555 chr3:13937349 NA -0.38 -5.75 -0.3 2e-8 Ovarian reserve; LUSC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg09365446 chr1:150670422 GOLPH3L -0.47 -7.03 -0.36 1.17e-11 Melanoma; LUSC cis rs35146811 0.735 rs1043915 chr7:99799845 T/A cg22906224 chr7:99728672 NA 0.46 6.45 0.33 4.02e-10 Coronary artery disease; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg00684032 chr4:1343700 KIAA1530 -0.36 -6.29 -0.33 9.86e-10 Obesity-related traits; LUSC cis rs6138458 1.000 rs227616 chr20:24908811 T/C cg06937882 chr20:24974362 C20orf3 -0.42 -7.0 -0.36 1.43e-11 Blood protein levels; LUSC cis rs9815354 0.812 rs114034165 chr3:41823297 G/A cg03022575 chr3:42003672 ULK4 0.85 8.66 0.43 2.12e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg12826209 chr6:26865740 GUSBL1 0.76 6.5 0.33 2.98e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9788682 0.747 rs28480606 chr15:78762313 A/G cg06917634 chr15:78832804 PSMA4 -0.48 -5.97 -0.31 6.23e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg22377939 chr1:150208607 ANP32E 0.42 6.34 0.33 7.64e-10 Triglycerides; LUSC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg18681998 chr4:17616180 MED28 0.82 14.82 0.63 1.55e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs72634258 0.554 rs4908704 chr1:7918904 A/G cg00042356 chr1:8021962 PARK7 0.58 6.71 0.34 8.12e-11 Inflammatory bowel disease; LUSC cis rs709400 0.930 rs2274268 chr14:104029378 C/G cg24130564 chr14:104152367 KLC1 -0.48 -6.78 -0.35 5.63e-11 Body mass index; LUSC cis rs8179 0.700 rs42044 chr7:92250140 T/G cg15732164 chr7:92237376 CDK6 -0.42 -5.98 -0.31 5.62e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs4975709 0.758 rs4975756 chr5:1882443 T/C cg15595755 chr5:1867978 NA 0.4 6.36 0.33 6.76e-10 Cardiovascular disease risk factors; LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg05025164 chr4:1340916 KIAA1530 -0.51 -7.8 -0.39 7.8e-14 Obesity-related traits; LUSC cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg13319975 chr6:146136371 FBXO30 -0.51 -7.8 -0.39 7.8500000000000006e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs950027 0.620 rs1153862 chr15:45631868 A/G cg26924012 chr15:45694286 SPATA5L1 0.77 12.26 0.56 8.62e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg11266682 chr4:10021025 SLC2A9 0.58 10.79 0.51 1.7e-23 Bone mineral density; LUSC cis rs7188861 0.813 rs1794021 chr16:11377234 G/A cg00044050 chr16:11439710 C16orf75 0.54 6.19 0.32 1.77e-9 HDL cholesterol; LUSC cis rs72781680 0.898 rs12614616 chr2:23996501 T/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg26597838 chr10:835615 NA 0.77 8.9 0.44 3.72e-17 Eosinophil percentage of granulocytes; LUSC cis rs34779708 0.966 rs1545757 chr10:35445588 A/T cg03585969 chr10:35415529 CREM 0.61 8.85 0.44 5.02e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs7824557 0.564 rs35009431 chr8:11232788 G/A cg08975724 chr8:8085496 FLJ10661 -0.47 -6.88 -0.35 2.99e-11 Retinal vascular caliber; LUSC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg00579200 chr11:133705235 NA -0.41 -5.94 -0.31 7.25e-9 Childhood ear infection; LUSC cis rs41271473 1.000 rs11578216 chr1:228880098 A/T cg10167378 chr1:228756711 NA -0.54 -6.56 -0.34 2.06e-10 Chronic lymphocytic leukemia; LUSC cis rs10761482 0.861 rs10994309 chr10:62105197 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg16339924 chr4:17578868 LAP3 0.49 7.29 0.37 2.22e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg06219351 chr7:158114137 PTPRN2 0.49 7.94 0.4 3.03e-14 Response to amphetamines; LUSC trans rs9929218 1.000 rs9936621 chr16:68798682 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -11.48 -0.53 6.38e-26 Colorectal cancer; LUSC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg07716408 chr11:68623521 NA -0.32 -6.19 -0.32 1.8e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.13 0.36 6.2e-12 Colorectal cancer; LUSC cis rs16937 0.711 rs12142514 chr1:205122529 A/G cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.24e-10 Schizophrenia; LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg11266682 chr4:10021025 SLC2A9 -0.51 -9.36 -0.46 1.25e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1371867 0.875 rs7830342 chr8:101327738 T/A cg06002616 chr8:101225028 SPAG1 -0.41 -6.83 -0.35 4.11e-11 Atrioventricular conduction; LUSC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.79 0.43 7.96e-17 Menarche (age at onset); LUSC cis rs13089785 1.000 rs35181974 chr3:123607884 C/A cg02012769 chr3:123398346 MYLK 0.32 5.79 0.3 1.66e-8 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg06636001 chr8:8085503 FLJ10661 -0.6 -8.86 -0.44 4.92e-17 Triglycerides; LUSC trans rs9329221 0.905 rs4433149 chr8:10249268 A/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.43 -0.33 4.34e-10 Neuroticism; LUSC cis rs7100689 0.556 rs946893 chr10:82023524 A/G cg00277334 chr10:82204260 NA -0.4 -5.75 -0.3 1.98e-8 Post bronchodilator FEV1; LUSC cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.75 7.49 0.38 6.31e-13 Initial pursuit acceleration; LUSC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg06740227 chr12:86229804 RASSF9 0.36 5.69 0.3 2.71e-8 Major depressive disorder; LUSC trans rs941408 0.515 rs2110118 chr19:2775144 T/C cg22153745 chr1:153894579 GATAD2B -0.49 -6.75 -0.35 6.6e-11 Total cholesterol levels; LUSC cis rs61931739 0.500 rs4436630 chr12:34394200 C/T cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg23758822 chr17:41437982 NA 1.04 20.11 0.74 1.65e-59 Menopause (age at onset); LUSC cis rs12422267 0.609 rs11246940 chr12:132623473 A/G cg09764611 chr12:132620959 NA -0.6 -9.3 -0.45 1.88e-18 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg03396347 chr1:1875803 NA -0.53 -11.67 -0.54 1.31e-26 Body mass index; LUSC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg00684032 chr4:1343700 KIAA1530 0.43 7.54 0.38 4.39e-13 Obesity-related traits; LUSC cis rs7582180 0.764 rs10460478 chr2:100919735 G/A cg12002119 chr2:101014098 CHST10 0.34 5.74 0.3 2.09e-8 Intelligence (multi-trait analysis); LUSC cis rs68170813 0.559 rs12534676 chr7:106943640 G/A cg02696742 chr7:106810147 HBP1 -0.64 -9.72 -0.47 7.9e-20 Coronary artery disease; LUSC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg19622623 chr12:86230825 RASSF9 0.44 6.27 0.32 1.11e-9 Major depressive disorder; LUSC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg13206674 chr6:150067644 NUP43 0.61 9.8 0.47 4.31e-20 Lung cancer; LUSC cis rs12464483 0.524 rs1901906 chr2:30884576 A/G cg12454169 chr2:30669597 LCLAT1 -0.62 -8.54 -0.42 4.8e-16 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs6960043 0.818 rs10228066 chr7:15063569 C/T cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC cis rs1949733 0.523 rs55977448 chr4:8542918 G/T cg11789530 chr4:8429930 ACOX3 -0.42 -6.07 -0.32 3.5e-9 Response to antineoplastic agents; LUSC cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg07636037 chr3:49044803 WDR6 0.69 9.14 0.45 6.17e-18 Menarche (age at onset); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg13033626 chr12:7342228 PEX5 0.49 6.82 0.35 4.18e-11 Mosquito bite size; LUSC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg03806693 chr22:41940476 POLR3H 0.95 12.89 0.58 3.76e-31 Vitiligo; LUSC cis rs41271473 0.750 rs72751931 chr1:228887129 G/T cg16512390 chr1:228756714 NA 0.47 5.71 0.3 2.5e-8 Chronic lymphocytic leukemia; LUSC cis rs748404 0.631 rs6493086 chr15:43655394 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.52 0.34 2.54e-10 Lung cancer; LUSC trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg03929089 chr4:120376271 NA 0.82 11.14 0.52 9.93e-25 Coronary artery disease; LUSC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg14784868 chr12:69753453 YEATS4 0.91 16.11 0.66 1.33e-43 Cerebrospinal fluid biomarker levels; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg21224049 chr4:668623 ATP5I 0.44 6.26 0.32 1.18e-9 Cognitive function;Information processing speed; LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs2120019 1.000 rs60425110 chr15:75333000 T/A cg09165964 chr15:75287851 SCAMP5 -1.15 -18.88 -0.72 1.33e-54 Blood trace element (Zn levels); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08616760 chr5:178157801 ZNF354A -0.38 -6.3 -0.33 9.63e-10 Electrocardiographic conduction measures; LUSC cis rs7188861 0.813 rs2867937 chr16:11398798 A/T cg00044050 chr16:11439710 C16orf75 0.55 6.15 0.32 2.21e-9 HDL cholesterol; LUSC cis rs240764 0.817 rs240145 chr6:101079610 A/C cg09795085 chr6:101329169 ASCC3 0.42 6.04 0.31 4.03e-9 Neuroticism; LUSC trans rs9467711 0.790 rs13198716 chr6:26582035 A/G cg06606381 chr12:133084897 FBRSL1 0.83 7.5 0.38 5.77e-13 Autism spectrum disorder or schizophrenia; LUSC trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg15704280 chr7:45808275 SEPT13 -0.44 -6.01 -0.31 4.86e-9 HDL cholesterol; LUSC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg17366294 chr4:99064904 C4orf37 0.5 8.64 0.43 2.42e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.72 6.56 0.34 2.1e-10 Lung cancer in ever smokers; LUSC cis rs62244186 0.541 rs3804583 chr3:44884647 G/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.5 7.83 0.39 6.39e-14 Depressive symptoms; LUSC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg06850241 chr22:41845214 NA -0.33 -6.01 -0.31 4.81e-9 Vitiligo; LUSC cis rs941408 0.515 rs878893 chr19:2781325 A/G cg17333051 chr19:2783644 SGTA 0.51 7.58 0.38 3.52e-13 Total cholesterol levels; LUSC cis rs4629710 0.563 rs9483238 chr6:131567196 A/T cg12606694 chr6:131520996 AKAP7 0.6 9.22 0.45 3.5e-18 Multiple myeloma (IgH translocation); LUSC cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 8.09e-13 Motion sickness; LUSC cis rs116988415 0.584 rs4902309 chr14:65238171 A/G cg25083366 chr14:65239357 SPTB -0.64 -6.42 -0.33 4.71e-10 Daytime sleep phenotypes; LUSC cis rs12681287 0.546 rs12546802 chr8:87499335 T/A cg00550725 chr8:87521180 FAM82B 0.45 5.87 0.31 1.07e-8 Caudate activity during reward; LUSC cis rs55871839 0.684 rs10108037 chr8:59812337 A/C cg07426533 chr8:59803705 TOX -0.36 -5.93 -0.31 7.66e-9 Pneumonia; LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg02018176 chr4:1364513 KIAA1530 0.57 10.06 0.48 5.77e-21 Obesity-related traits; LUSC cis rs2115630 0.967 rs28595395 chr15:85334952 T/C cg09876464 chr15:85330779 ZNF592 0.36 6.55 0.34 2.21e-10 P wave terminal force; LUSC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg05294307 chr14:35346193 BAZ1A -0.58 -7.14 -0.36 5.92e-12 Psoriasis; LUSC cis rs7937682 0.889 rs10789844 chr11:111579109 A/T cg19812747 chr11:111475976 SIK2 -0.46 -6.5 -0.34 2.93e-10 Primary sclerosing cholangitis; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.9 0.44 3.55e-17 Prudent dietary pattern; LUSC cis rs1113500 0.933 rs10785834 chr1:108639101 A/C cg06207961 chr1:108661230 NA 0.41 7.46 0.38 7.43e-13 Growth-regulated protein alpha levels; LUSC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg23649088 chr2:200775458 C2orf69 0.54 7.46 0.38 7.54e-13 Schizophrenia; LUSC cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg19077165 chr18:44547161 KATNAL2 0.43 6.47 0.33 3.45e-10 Personality dimensions; LUSC cis rs929596 0.755 rs4148325 chr2:234673309 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.65 -11.04 -0.52 2.35e-24 Total bilirubin levels in HIV-1 infection; LUSC cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg07606381 chr6:8435919 SLC35B3 0.75 12.63 0.57 3.66e-30 Motion sickness; LUSC trans rs11098499 0.779 rs10016060 chr4:120298412 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg27165867 chr14:105738592 BRF1 -0.55 -8.03 -0.4 1.7e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs4363385 0.791 rs11205177 chr1:153002502 G/A cg25856811 chr1:152973957 SPRR3 -0.36 -5.94 -0.31 6.97e-9 Inflammatory skin disease; LUSC cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg15839431 chr19:19639596 YJEFN3 0.66 7.28 0.37 2.39e-12 Bipolar disorder; LUSC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg18681998 chr4:17616180 MED28 0.89 17.33 0.69 1.87e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.543 rs9371533 chr6:150210681 G/A cg09699651 chr6:150184138 LRP11 0.45 6.92 0.35 2.33e-11 Lung cancer; LUSC cis rs9300255 0.664 rs28636834 chr12:123871070 A/C cg13010344 chr12:123464640 ARL6IP4 0.49 6.22 0.32 1.48e-9 Neutrophil percentage of white cells; LUSC cis rs7572644 0.699 rs12470614 chr2:28217327 C/T cg27432699 chr2:27873401 GPN1 0.5 6.84 0.35 3.78e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -7.0 -0.36 1.39e-11 Psoriasis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24923975 chr12:101801647 ARL1 -0.46 -6.01 -0.31 4.83e-9 Hepatitis; LUSC cis rs1008375 0.932 rs9291660 chr4:17663414 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.45 0.33 4e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs950169 0.922 rs62021167 chr15:85118051 T/A cg17507749 chr15:85114479 UBE2QP1 0.7 9.14 0.45 6.29e-18 Schizophrenia; LUSC cis rs68092024 0.704 rs704576 chr3:99487154 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -7.02 -0.36 1.28e-11 Cleft lip with or without cleft palate; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg08859206 chr1:53392774 SCP2 -0.68 -13.09 -0.58 7.08e-32 Monocyte count; LUSC cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg12027761 chr17:38279750 MSL1 -0.44 -6.32 -0.33 8.48e-10 Hepatitis; LUSC cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.78 -0.35 5.36e-11 Monocyte percentage of white cells; LUSC cis rs2486288 0.656 rs7166580 chr15:45571209 C/G cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.84 -0.51 1.2e-23 Glomerular filtration rate; LUSC cis rs12912251 1.000 rs12903120 chr15:38988097 G/T cg01338139 chr15:38987640 C15orf53 -0.5 -6.79 -0.35 5.12e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs4253772 0.872 rs4253776 chr22:46629479 C/T cg24881330 chr22:46731750 TRMU -0.69 -7.27 -0.37 2.5e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs11098499 0.754 rs12507565 chr4:120251121 G/A cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC trans rs2018683 0.707 rs7799357 chr7:28970118 A/G cg19402173 chr7:128379420 CALU -0.47 -7.18 -0.37 4.42e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC trans rs637571 0.726 rs669371 chr11:65674153 G/T cg17712092 chr4:129076599 LARP1B -0.97 -14.49 -0.62 2.86e-37 Eosinophil percentage of white cells; LUSC cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg05347473 chr6:146136440 FBXO30 0.46 7.66 0.39 1.98e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs896854 0.573 rs11996455 chr8:95853708 G/A cg16049864 chr8:95962084 TP53INP1 -0.55 -10.08 -0.48 4.73e-21 Type 2 diabetes; LUSC cis rs13082711 0.522 rs569960 chr3:27329540 C/T cg02860705 chr3:27208620 NA 0.48 8.93 0.44 2.93e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.62 0.47 1.63e-19 Bipolar disorder; LUSC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg04352962 chr1:209979756 IRF6 0.52 5.79 0.3 1.65e-8 Coronary artery disease; LUSC cis rs7312933 0.558 rs1669936 chr12:42813509 C/A cg01256987 chr12:42539512 GXYLT1 0.36 6.61 0.34 1.53e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs208520 0.690 rs851458 chr6:66813279 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.68 -0.7 7.51e-50 Exhaled nitric oxide output; LUSC cis rs881375 0.678 rs3761846 chr9:123689597 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 6.0 0.31 5.02e-9 Rheumatoid arthritis; LUSC cis rs12410462 0.681 rs4614224 chr1:227574966 C/T cg23173402 chr1:227635558 NA 0.56 6.26 0.32 1.15e-9 Major depressive disorder; LUSC cis rs9747201 0.925 rs8072670 chr17:80159566 T/C cg18209359 chr17:80159595 CCDC57 -0.37 -6.28 -0.32 1.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg11608241 chr8:8085544 FLJ10661 -0.46 -7.01 -0.36 1.35e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7954584 0.583 rs10770186 chr12:122361412 A/G cg21171335 chr12:122356390 WDR66 0.55 7.8 0.39 7.97e-14 Mean corpuscular volume; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14428862 chr20:814736 FAM110A 0.48 6.48 0.33 3.36e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs950027 0.549 rs9920634 chr15:45596546 G/T cg09092052 chr15:45571596 NA 0.49 6.81 0.35 4.55e-11 Response to fenofibrate (adiponectin levels); LUSC cis rs2295359 0.892 rs4655687 chr1:67649946 C/T cg03340356 chr1:67600835 NA 0.42 6.64 0.34 1.27e-10 Psoriasis; LUSC cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg16230307 chr14:35515116 FAM177A1 0.73 8.45 0.42 8.86e-16 Psoriasis; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.46 5.95 0.31 6.83e-9 Renal function-related traits (BUN); LUSC cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg14993813 chr1:46806288 NSUN4 -0.52 -7.36 -0.37 1.47e-12 Menopause (age at onset); LUSC trans rs7939886 0.920 rs4612826 chr11:55948005 C/A cg15704280 chr7:45808275 SEPT13 0.89 6.88 0.35 3e-11 Myopia (pathological); LUSC cis rs3820928 0.874 rs4675132 chr2:227841792 A/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.83 -0.39 6.69e-14 Pulmonary function; LUSC trans rs61931739 0.534 rs4365131 chr12:34053308 T/C cg26384229 chr12:38710491 ALG10B 0.7 10.84 0.51 1.12e-23 Morning vs. evening chronotype; LUSC cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg17063962 chr7:91808500 NA 0.59 9.36 0.46 1.22e-18 Breast cancer; LUSC cis rs1003719 0.680 rs2835670 chr21:38581114 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.18 -0.49 2.18e-21 Eye color traits; LUSC trans rs225245 0.817 rs225255 chr17:33955243 A/G cg19694781 chr19:47549865 TMEM160 0.44 7.08 0.36 8.68e-12 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs17401966 0.838 rs11580854 chr1:10293565 G/A cg19773385 chr1:10388646 KIF1B -0.53 -9.04 -0.44 1.31e-17 Hepatocellular carcinoma; LUSC cis rs453301 0.624 rs2288671 chr8:8860894 T/C cg08975724 chr8:8085496 FLJ10661 0.51 7.48 0.38 6.64e-13 Joint mobility (Beighton score); LUSC trans rs4332037 0.950 rs56403963 chr7:1946130 C/G cg25206134 chr2:45395956 NA 0.57 6.52 0.34 2.6200000000000003e-10 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22302626 chr19:10196930 C19orf66 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder and schizophrenia; LUSC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg07926092 chr13:79233506 RNF219 0.55 7.0 0.36 1.44e-11 Large artery stroke; LUSC trans rs11098499 0.820 rs13128602 chr4:120459366 C/T cg25214090 chr10:38739885 LOC399744 -0.51 -7.58 -0.38 3.54e-13 Corneal astigmatism; LUSC cis rs909002 0.800 rs10914459 chr1:32096918 T/C cg01639898 chr1:32083012 HCRTR1 0.31 7.36 0.37 1.48e-12 Intelligence (multi-trait analysis); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05694382 chr6:133136015 RPS12;SNORD101 -0.44 -6.01 -0.31 4.89e-9 Hepatitis; LUSC cis rs7809950 1.000 rs7809950 chr7:107237807 T/C cg23024343 chr7:107201750 COG5 0.57 8.94 0.44 2.64e-17 Coronary artery disease; LUSC trans rs6601327 0.641 rs11778555 chr8:9587574 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.4 -0.33 5.21e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7568458 0.709 rs2028898 chr2:85777270 G/A cg02493740 chr2:85810744 VAMP5 -0.53 -9.26 -0.45 2.59e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11890956 chr21:40555474 PSMG1 -0.85 -14.94 -0.63 5.4300000000000003e-39 Cognitive function; LUSC cis rs9549367 0.713 rs9549352 chr13:113833221 A/G cg18105134 chr13:113819100 PROZ -0.76 -10.68 -0.5 4.38e-23 Platelet distribution width; LUSC cis rs2070488 0.636 rs2284817 chr3:38510388 A/G cg24069376 chr3:38537580 EXOG 0.36 6.41 0.33 5.01e-10 Electrocardiographic conduction measures; LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 6.14 0.32 2.3e-9 Bipolar disorder; LUSC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.62 -10.94 -0.51 5.3e-24 Menopause (age at onset); LUSC cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg04450456 chr4:17643702 FAM184B 0.38 6.5 0.34 2.88e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7762018 0.760 rs28660085 chr6:170101996 C/G cg15038512 chr6:170123185 PHF10 0.53 7.08 0.36 8.47e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs6546550 0.901 rs13015457 chr2:70125763 G/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 4.97e-14 Prudent dietary pattern; LUSC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.19 0.32 1.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs61935443 0.614 rs61935662 chr12:95313296 A/G cg21533806 chr12:95267307 NA 0.49 5.75 0.3 2.04e-8 Schizophrenia; LUSC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.52 0.34 2.59e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs7804356 0.953 rs10242572 chr7:26895065 T/C cg03456212 chr7:26904342 SKAP2 -0.52 -6.04 -0.31 4.16e-9 Type 1 diabetes; LUSC cis rs2204008 0.623 rs4882302 chr12:38415608 T/A cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.07e-10 Bladder cancer; LUSC cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg21573476 chr21:45109991 RRP1B 0.39 6.04 0.31 4.22e-9 Mean corpuscular volume; LUSC cis rs9467773 1.000 rs6933176 chr6:26540178 G/A cg11502198 chr6:26597334 ABT1 0.59 9.37 0.46 1.15e-18 Intelligence (multi-trait analysis); LUSC trans rs71435601 0.628 rs532225 chr2:21397637 T/C cg20757404 chr19:378427 NA 0.37 5.95 0.31 6.74e-9 Cholesterol, total; LUSC cis rs2859741 0.967 rs494157 chr1:37512995 C/T cg09363841 chr1:37513479 NA 0.39 7.78 0.39 9.34e-14 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs6700896 0.500 rs6693842 chr1:66078405 T/C cg04111102 chr1:66153794 NA 0.31 6.83 0.35 4.14e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.65 -0.34 1.17e-10 Arsenic metabolism; LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg08280861 chr8:58055591 NA 0.54 6.46 0.33 3.73e-10 Developmental language disorder (linguistic errors); LUSC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg05527609 chr1:210001259 C1orf107 0.45 6.71 0.34 8.4e-11 Monobrow; LUSC cis rs9905704 0.633 rs2632518 chr17:56512236 T/C cg19466818 chr17:56409534 MIR142 -0.32 -6.1 -0.32 2.98e-9 Testicular germ cell tumor; LUSC cis rs17155006 0.746 rs425623 chr7:107747465 C/T cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs1564271 0.553 rs2489583 chr10:26987698 A/G cg13837822 chr10:26931731 LOC731789 0.46 9.31 0.45 1.78e-18 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs7760535 0.764 rs2343614 chr6:111705158 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.35 -6.45 -0.33 3.82e-10 Metabolic traits; LUSC cis rs1595825 0.891 rs111340803 chr2:198612877 A/G cg00982548 chr2:198649783 BOLL -0.58 -7.21 -0.37 3.87e-12 Ulcerative colitis; LUSC cis rs4721295 0.546 rs1637766 chr7:2204400 G/A cg02951883 chr7:2050386 MAD1L1 0.46 8.15 0.41 7.59e-15 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs9300255 0.739 rs2337934 chr12:123745359 A/G cg00376283 chr12:123451042 ABCB9 0.66 8.34 0.42 2e-15 Neutrophil percentage of white cells; LUSC cis rs9287719 0.967 rs13034061 chr2:10739651 C/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs1371867 0.846 rs2919471 chr8:101232701 T/C cg06636551 chr8:101224915 SPAG1 0.48 8.79 0.43 7.75e-17 Atrioventricular conduction; LUSC cis rs4494114 1.000 rs880303 chr1:39340282 C/T cg25970120 chr1:39325951 RRAGC -0.41 -6.44 -0.33 4.15e-10 Blood protein levels; LUSC cis rs8017423 0.967 rs2277515 chr14:90723000 A/G cg14092571 chr14:90743983 NA -0.36 -5.86 -0.31 1.11e-8 Mortality in heart failure; LUSC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg21782813 chr7:2030301 MAD1L1 0.44 7.17 0.37 4.73e-12 Schizophrenia; LUSC cis rs12760731 0.720 rs12741848 chr1:178334941 A/G cg00404053 chr1:178313656 RASAL2 0.53 6.09 0.32 3.06e-9 Obesity-related traits; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg01219382 chr4:184328462 NA 0.37 6.13 0.32 2.45e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg22903657 chr4:1355424 KIAA1530 -0.5 -8.36 -0.42 1.74e-15 Obesity-related traits; LUSC cis rs1670533 1.000 rs676561 chr4:1083112 C/T cg27284194 chr4:1044797 NA 0.59 8.79 0.43 7.77e-17 Recombination rate (females); LUSC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs10203711 0.933 rs907110 chr2:239566391 C/T cg14580085 chr2:239553406 NA 0.41 6.93 0.35 2.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2204008 0.693 rs12372025 chr12:38202028 G/A cg13010199 chr12:38710504 ALG10B 0.71 10.99 0.52 3.48e-24 Bladder cancer; LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.5 -0.38 5.8e-13 Bipolar disorder; LUSC cis rs7681440 0.626 rs1372510 chr4:90817259 G/A cg15133208 chr4:90757351 SNCA -0.33 -5.69 -0.3 2.75e-8 Dementia with Lewy bodies; LUSC trans rs8072100 0.967 rs8078880 chr17:45676526 G/C cg04995722 chr7:26192034 NFE2L3 0.37 6.15 0.32 2.21e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs754466 0.874 rs61855849 chr10:79659934 G/A cg17075019 chr10:79541650 NA -0.64 -8.3 -0.41 2.54e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs757278 0.591 rs6980032 chr7:117303145 G/T cg10524701 chr7:117356490 CTTNBP2 0.41 5.92 0.31 8.15e-9 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg21573476 chr21:45109991 RRP1B -0.36 -5.84 -0.3 1.21e-8 Mean corpuscular volume; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22618350 chr1:91487603 ZNF644 -0.42 -6.18 -0.32 1.9e-9 Electrocardiographic conduction measures; LUSC cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg17063962 chr7:91808500 NA 0.58 9.24 0.45 2.94e-18 Breast cancer; LUSC cis rs7829975 0.846 rs6601724 chr8:8544872 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.65 -0.43 2.27e-16 Mood instability; LUSC cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg22307029 chr19:49891270 CCDC155 0.61 8.68 0.43 1.81e-16 Multiple sclerosis; LUSC cis rs7312933 0.558 rs1796382 chr12:42840955 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.81 -0.35 4.57e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.99 -0.44 1.91e-17 Axial length; LUSC cis rs1524927 0.966 rs12704871 chr7:96334274 C/T cg03808172 chr7:96339361 SHFM1 -0.45 -6.94 -0.35 2.07e-11 Total body bone mineral density; LUSC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.92 0.35 2.27e-11 Multiple sclerosis; LUSC cis rs4851254 0.961 rs7583067 chr2:100796850 C/T cg07810366 chr2:100720526 AFF3 -0.36 -5.73 -0.3 2.27e-8 Intelligence (multi-trait analysis); LUSC cis rs2078087 0.568 rs504895 chr1:183215522 G/C cg13843938 chr1:183241246 NMNAT2 0.41 6.77 0.35 5.85e-11 Obesity-related traits; LUSC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg10645314 chr2:3704589 ALLC -0.68 -10.35 -0.49 5.83e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs1322512 0.917 rs2250013 chr6:153006539 A/T cg03415253 chr6:152958462 SYNE1 0.38 5.65 0.3 3.38e-8 Tonometry; LUSC cis rs72781680 0.898 rs55846516 chr2:24158003 T/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs6121246 0.609 rs6060652 chr20:30266845 A/G cg13852791 chr20:30311386 BCL2L1 0.94 14.29 0.62 1.81e-36 Mean corpuscular hemoglobin; LUSC cis rs9487051 0.735 rs1260595 chr6:109519873 T/G cg01475377 chr6:109611718 NA -0.36 -6.18 -0.32 1.9e-9 Reticulocyte fraction of red cells; LUSC cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 7.01 0.36 1.29e-11 Height; LUSC cis rs68149176 0.772 rs997761 chr16:87879522 A/C cg03553613 chr16:87879502 SLC7A5 0.45 6.13 0.32 2.47e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg21545522 chr1:205238299 TMCC2 0.49 9.21 0.45 3.82e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg18512352 chr11:47633146 NA -0.46 -9.2 -0.45 3.88e-18 Subjective well-being; LUSC cis rs523522 0.885 rs524735 chr12:121022099 T/C cg27279351 chr12:120934652 DYNLL1 0.66 8.93 0.44 2.9e-17 High light scatter reticulocyte count; LUSC cis rs3099143 1.000 rs3099143 chr15:77104856 A/C cg21673338 chr15:77095150 SCAPER -0.76 -7.17 -0.37 4.88e-12 Recalcitrant atopic dermatitis; LUSC cis rs72634258 0.945 rs2294889 chr1:8075934 A/G cg26816564 chr1:7831052 VAMP3 0.49 6.53 0.34 2.41e-10 Inflammatory bowel disease; LUSC cis rs113835537 0.935 rs75863187 chr11:66443461 G/A cg24851651 chr11:66362959 CCS 0.53 6.56 0.34 2.05e-10 Airway imaging phenotypes; LUSC cis rs6977660 0.714 rs10486365 chr7:19801364 A/G cg05791153 chr7:19748676 TWISTNB 0.67 7.2 0.37 4.03e-12 Thyroid stimulating hormone; LUSC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg18190219 chr22:46762943 CELSR1 -0.48 -6.0 -0.31 5.01e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs10843647 0.967 rs1485411 chr12:30331167 G/T cg12718339 chr12:29936407 TMTC1 -0.34 -5.69 -0.3 2.73e-8 Glucose homeostasis traits; LUSC cis rs73200209 0.744 rs2392967 chr12:116531742 T/C cg01776926 chr12:116560359 MED13L -0.49 -5.98 -0.31 5.86e-9 Total body bone mineral density; LUSC cis rs4663866 0.901 rs4663298 chr2:239139907 G/A cg16914508 chr2:239161102 PER2 0.61 6.59 0.34 1.7e-10 Irritable bowel syndrome; LUSC cis rs4144743 0.941 rs7211563 chr17:45324061 T/C cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg03233332 chr7:66118400 NA 0.4 5.91 0.31 8.36e-9 Aortic root size; LUSC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg07395648 chr5:131743802 NA 0.39 6.12 0.32 2.55e-9 Asthma (sex interaction); LUSC cis rs10979 1.000 rs9399447 chr6:143896163 T/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg11062466 chr8:58055876 NA 0.47 6.3 0.33 9.47e-10 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg27494647 chr7:150038898 RARRES2 0.47 7.29 0.37 2.19e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs66716358 0.710 rs10838256 chr11:44321199 T/C cg16977035 chr11:44330474 ALX4 -0.36 -5.91 -0.31 8.29e-9 Monobrow; LUSC cis rs8062405 0.755 rs4149398 chr16:28608938 C/G cg07382826 chr16:28625726 SULT1A1 0.28 5.98 0.31 5.77e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs7647973 0.560 rs77473999 chr3:49777660 T/C cg21659725 chr3:3221576 CRBN 0.69 8.17 0.41 6.29e-15 Menarche (age at onset); LUSC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg21017887 chr14:105400489 NA 0.7 13.52 0.59 1.63e-33 Rheumatoid arthritis; LUSC cis rs2797160 1.000 rs6569435 chr6:125998186 T/C cg05901451 chr6:126070800 HEY2 -0.59 -8.83 -0.43 6.14e-17 Endometrial cancer; LUSC cis rs4899554 0.640 rs1569328 chr14:75741751 A/G cg18117039 chr14:75741733 NA -0.55 -7.62 -0.38 2.59e-13 Inflammatory bowel disease; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg19346786 chr7:2764209 NA -0.48 -8.05 -0.4 1.52e-14 Height; LUSC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.41 0.46 8.02e-19 Monocyte percentage of white cells; LUSC cis rs10876993 0.928 rs813854 chr12:58071347 A/G cg18357645 chr12:58087776 OS9 0.55 8.23 0.41 4.17e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs7829975 0.711 rs4481596 chr8:8704330 G/C cg11608241 chr8:8085544 FLJ10661 0.4 5.73 0.3 2.25e-8 Mood instability; LUSC cis rs12681288 0.550 rs12549204 chr8:959085 G/T cg04851639 chr8:1020857 NA -0.35 -7.0 -0.36 1.4e-11 Schizophrenia; LUSC cis rs854765 0.693 rs4924823 chr17:17764502 A/G cg16928487 chr17:17741425 SREBF1 0.45 8.92 0.44 3.14e-17 Total body bone mineral density; LUSC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg04539111 chr16:67997858 SLC12A4 -0.47 -6.3 -0.33 9.58e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg12463550 chr7:65579703 CRCP -0.63 -5.68 -0.3 2.92e-8 Diabetic kidney disease; LUSC cis rs7089973 0.872 rs35628210 chr10:116630031 G/A cg23260525 chr10:116636907 FAM160B1 0.4 8.12 0.41 8.78e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7584330 0.518 rs7585975 chr2:238439089 G/A cg16989719 chr2:238392110 NA -0.5 -6.41 -0.33 4.87e-10 Prostate cancer; LUSC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg22800045 chr5:56110881 MAP3K1 0.8 10.13 0.48 3.33e-21 Initial pursuit acceleration; LUSC cis rs6701037 1.000 rs6677097 chr1:175123897 C/G cg17845761 chr1:175162550 KIAA0040 -0.3 -5.88 -0.31 1.02e-8 Alcohol dependence; LUSC cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.37 -0.46 1.09e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg09436375 chr6:42928200 GNMT -0.3 -6.89 -0.35 2.75e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg03452623 chr4:187889614 NA -0.88 -18.29 -0.71 2.99e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs7903847 0.642 rs10882926 chr10:99160690 C/T cg20016023 chr10:99160130 RRP12 0.29 7.35 0.37 1.57e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs4660306 0.677 rs781059 chr1:45934562 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.4 -5.67 -0.3 3.07e-8 Homocysteine levels; LUSC cis rs4689388 0.890 rs4689397 chr4:6299387 G/A cg00701064 chr4:6280414 WFS1 0.6 14.49 0.62 3.05e-37 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11122272 0.735 rs2491416 chr1:231547335 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.66 10.39 0.49 4.42e-22 Hemoglobin concentration; LUSC cis rs2274273 0.638 rs3825614 chr14:55729387 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.66 0.47 1.26e-19 Protein biomarker; LUSC cis rs1670533 1.000 rs2290408 chr4:1067267 A/C cg02018176 chr4:1364513 KIAA1530 -0.42 -6.05 -0.31 3.81e-9 Recombination rate (females); LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg27535305 chr1:53392650 SCP2 0.53 10.25 0.49 1.29e-21 Monocyte count; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg16031515 chr1:205743344 RAB7L1 -0.28 -6.11 -0.32 2.81e-9 Menarche (age at onset); LUSC cis rs600231 0.683 rs588298 chr11:65253574 A/G cg17120908 chr11:65337727 SSSCA1 -0.53 -9.31 -0.45 1.78e-18 Bone mineral density; LUSC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg11845111 chr2:191398756 TMEM194B -0.54 -9.31 -0.45 1.79e-18 Pulse pressure; LUSC cis rs1577917 1.000 rs13217384 chr6:86720000 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.26 -0.32 1.21e-9 Response to antipsychotic treatment; LUSC cis rs2976388 1.000 rs1045574 chr8:143763958 C/T cg17252645 chr8:143867129 LY6D -0.36 -6.28 -0.32 1.07e-9 Urinary tract infection frequency; LUSC cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg13736514 chr6:26305472 NA -0.45 -8.98 -0.44 2.05e-17 Educational attainment; LUSC cis rs2404602 0.647 rs35940181 chr15:77180019 G/A cg23625390 chr15:77176239 SCAPER -0.66 -10.19 -0.49 2.03e-21 Blood metabolite levels; LUSC cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg19875535 chr5:140030758 IK -0.54 -8.91 -0.44 3.39e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs6445797 0.632 rs6805469 chr3:56631235 G/T cg13792233 chr3:56591045 CCDC66 0.4 5.72 0.3 2.41e-8 Gastritis; LUSC cis rs62244186 0.566 rs2135531 chr3:44881158 C/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.44 6.48 0.33 3.24e-10 Depressive symptoms; LUSC cis rs9326248 0.581 rs10892076 chr11:116988936 G/A cg26566898 chr11:117069891 TAGLN 0.39 7.57 0.38 3.74e-13 Blood protein levels; LUSC cis rs911119 1.000 rs6114206 chr20:23611789 A/G cg16589663 chr20:23618590 CST3 0.59 6.95 0.36 1.88e-11 Chronic kidney disease; LUSC cis rs9463078 0.605 rs13216116 chr6:44936681 C/T cg25276700 chr6:44698697 NA 0.28 5.85 0.3 1.17e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs3740393 0.562 rs11191393 chr10:104527430 C/G cg05855489 chr10:104503620 C10orf26 -0.57 -5.76 -0.3 1.89e-8 Microalbuminuria; LUSC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.74 0.39 1.16e-13 Obesity-related traits; LUSC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg20307385 chr11:47447363 PSMC3 -0.46 -5.97 -0.31 6.16e-9 Subjective well-being; LUSC cis rs9612 1.000 rs346524 chr19:44260572 T/C cg08581076 chr19:44259116 C19orf61 0.53 6.71 0.34 8.22e-11 Exhaled nitric oxide output; LUSC cis rs7267979 0.966 rs2257461 chr20:25265554 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.49 0.75 5.16e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg25072359 chr17:41440525 NA -0.6 -8.68 -0.43 1.72e-16 Menopause (age at onset); LUSC cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg02228329 chr11:64053129 BAD;GPR137 0.42 6.05 0.31 3.98e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7246967 0.673 rs4627499 chr19:22832633 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs2820315 1.000 rs2820314 chr1:201872209 A/C cg10061532 chr1:201886748 LMOD1 0.27 5.95 0.31 6.82e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs894734 0.535 rs10783613 chr12:54321966 G/T cg25024717 chr12:54324583 NA -0.38 -6.62 -0.34 1.47e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg11218175 chr11:495084 RNH1 0.53 5.66 0.3 3.31e-8 Body mass index; LUSC cis rs9660992 0.967 rs1172135 chr1:205247160 G/C cg21545522 chr1:205238299 TMCC2 0.44 8.18 0.41 5.86e-15 Mean corpuscular volume;Mean platelet volume; LUSC cis rs3862435 0.764 rs16944523 chr15:91038294 A/G cg22089800 chr15:90895588 ZNF774 0.52 5.65 0.3 3.45e-8 Response to exercise (triglyceride level interaction); LUSC cis rs34734847 1.000 rs56273049 chr12:121156041 A/T cg27246729 chr12:121163418 ACADS 0.47 7.49 0.38 6.33e-13 Mean corpuscular volume; LUSC cis rs4975709 0.959 rs9312959 chr5:1877008 G/A cg20790798 chr5:1857306 NA -0.38 -5.78 -0.3 1.71e-8 Cardiovascular disease risk factors; LUSC cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg06784218 chr1:46089804 CCDC17 0.55 11.25 0.52 3.97e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7267979 0.816 rs6138593 chr20:25504492 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.57 0.67 2.02e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs34779708 0.931 rs11597392 chr10:35288575 T/C cg04310649 chr10:35416472 CREM -0.41 -6.14 -0.32 2.29e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs926938 0.606 rs6537844 chr1:115289295 G/A cg12756093 chr1:115239321 AMPD1 -0.5 -7.09 -0.36 8.1e-12 Autism; LUSC trans rs6089829 0.962 rs6089824 chr20:61659207 A/G cg17470723 chr8:74884337 TCEB1 0.5 7.38 0.37 1.23e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg11632617 chr15:75315747 PPCDC -0.54 -7.01 -0.36 1.29e-11 Blood trace element (Zn levels); LUSC cis rs12545109 0.571 rs7002482 chr8:57295200 C/T cg09654669 chr8:57350985 NA -0.45 -5.98 -0.31 5.7e-9 Obesity-related traits; LUSC cis rs4629710 0.592 rs35017713 chr6:131581212 G/A cg12700074 chr6:131571435 AKAP7 -0.34 -5.66 -0.3 3.19e-8 Multiple myeloma (IgH translocation); LUSC cis rs709400 0.832 rs10145755 chr14:104121984 C/T cg24130564 chr14:104152367 KLC1 -0.51 -7.41 -0.38 1.04e-12 Body mass index; LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 11.4 0.53 1.17e-25 Alzheimer's disease; LUSC cis rs7267979 0.866 rs6138609 chr20:25570985 T/A cg03522245 chr20:25566470 NINL 0.36 5.85 0.3 1.16e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs977987 0.806 rs4887818 chr16:75361995 T/C cg03315344 chr16:75512273 CHST6 0.53 10.22 0.49 1.57e-21 Dupuytren's disease; LUSC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.93 -0.4 3.38e-14 Lymphocyte counts; LUSC cis rs9653442 0.564 rs11123809 chr2:100758137 C/T cg22139774 chr2:100720529 AFF3 -0.41 -7.05 -0.36 1.06e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs34734847 0.933 rs998727 chr12:121149064 T/G cg21892295 chr12:121157589 UNC119B -0.46 -8.15 -0.41 7.24e-15 Mean corpuscular volume; LUSC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg06558623 chr16:89946397 TCF25 1.0 10.72 0.51 2.96e-23 Skin colour saturation; LUSC cis rs9815354 0.812 rs56994465 chr3:42061606 A/G cg03022575 chr3:42003672 ULK4 0.59 6.35 0.33 7.17e-10 Pulse pressure;Diastolic blood pressure; LUSC trans rs7829975 0.711 rs4841051 chr8:8685646 C/T cg21775007 chr8:11205619 TDH -0.45 -6.45 -0.33 3.9e-10 Mood instability; LUSC cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg14530993 chr4:882597 GAK 0.74 7.27 0.37 2.57e-12 Intelligence (multi-trait analysis); LUSC cis rs79911532 0.551 rs74999892 chr7:75756464 T/C cg03592824 chr7:75666768 STYXL1 0.67 6.37 0.33 6.32e-10 Mononucleosis; LUSC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs7246657 0.943 rs10422074 chr19:37894236 T/C cg23950597 chr19:37808831 NA -0.64 -7.59 -0.38 3.16e-13 Coronary artery calcification; LUSC cis rs9911578 0.757 rs8081906 chr17:56631907 A/T cg10487724 chr17:56770010 TEX14;RAD51C -0.41 -5.92 -0.31 7.78e-9 Intelligence (multi-trait analysis); LUSC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg04234412 chr22:24373322 LOC391322 -0.59 -7.43 -0.38 9.17e-13 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg05347473 chr6:146136440 FBXO30 0.65 11.4 0.53 1.16e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg04369109 chr6:150039330 LATS1 -0.59 -8.81 -0.43 6.8e-17 Lung cancer; LUSC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg26818010 chr10:134567672 INPP5A -0.86 -11.29 -0.53 2.89e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9287719 0.967 rs6432117 chr2:10749359 G/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs1044826 0.647 rs4683463 chr3:139196946 T/G cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.79e-11 Obesity-related traits; LUSC cis rs477692 0.699 rs471357 chr10:131389373 C/G cg11019008 chr10:131425282 MGMT 0.41 5.91 0.31 8.46e-9 Response to temozolomide; LUSC cis rs4595586 0.525 rs2892450 chr12:39363678 G/A cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg24846343 chr22:24311635 DDTL 0.78 17.9 0.7 1.06e-50 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.76 -0.51 2.23e-23 Chronic sinus infection; LUSC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg13902645 chr11:5959945 NA -0.59 -8.28 -0.41 3.07e-15 DNA methylation (variation); LUSC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg11859384 chr17:80120422 CCDC57 0.36 5.71 0.3 2.46e-8 Life satisfaction; LUSC cis rs853679 0.607 rs13199649 chr6:27868792 C/T cg26958806 chr6:27640298 NA 0.76 5.72 0.3 2.39e-8 Depression; LUSC cis rs72781680 0.898 rs7569424 chr2:24036222 A/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.74 11.27 0.53 3.35e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6952809 0.532 rs6952152 chr7:2440912 G/A cg23289794 chr7:2394357 EIF3B -0.76 -9.99 -0.48 9.5e-21 Multiple sclerosis; LUSC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.32 6.54 0.34 2.25e-10 Schizophrenia; LUSC trans rs8073060 0.586 rs225307 chr17:33918311 A/G cg19694781 chr19:47549865 TMEM160 1.12 17.91 0.7 9.17e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs11690935 0.959 rs6758704 chr2:172655097 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.68 -0.63 5.51e-38 Schizophrenia; LUSC cis rs10144321 0.644 rs11160580 chr14:100794314 T/C cg14882082 chr14:100845427 WDR25 -0.41 -7.24 -0.37 3.14e-12 Menarche (age at onset); LUSC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs11608355 0.545 rs11612500 chr12:109897136 T/C cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs911555 0.755 rs1116095 chr14:103931879 A/G cg12935359 chr14:103987150 CKB 0.67 10.87 0.51 9.08e-24 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg20283391 chr11:68216788 NA -0.52 -7.74 -0.39 1.18e-13 Total body bone mineral density; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08086221 chr19:48112482 GLTSCR1 -0.44 -6.0 -0.31 5.23e-9 Hepatitis; LUSC cis rs7568458 0.837 rs3770098 chr2:85805367 C/A cg23752985 chr2:85803571 VAMP8 0.37 8.0 0.4 2.03e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4319547 0.656 rs3817011 chr12:122819566 C/T cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.4 -0.42 1.33e-15 Body mass index; LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg08470875 chr2:26401718 FAM59B -0.69 -9.37 -0.46 1.16e-18 Gut microbiome composition (summer); LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.63 -0.57 3.75e-30 Alzheimer's disease; LUSC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg05082376 chr22:42548792 NA -0.43 -6.83 -0.35 4.02e-11 Schizophrenia; LUSC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg16339924 chr4:17578868 LAP3 0.54 8.27 0.41 3.24e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg07424592 chr7:64974309 NA 0.69 5.99 0.31 5.45e-9 Diabetic kidney disease; LUSC trans rs71435601 0.628 rs531380 chr2:21397561 C/G cg20757404 chr19:378427 NA 0.37 6.01 0.31 4.87e-9 Cholesterol, total; LUSC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs9653442 0.510 rs11891046 chr2:100794402 C/G cg22139774 chr2:100720529 AFF3 -0.4 -6.95 -0.36 1.96e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6867913 0.709 rs891987 chr5:141467196 A/T cg08523384 chr5:141488047 NDFIP1 0.42 7.0 0.36 1.4e-11 Asthma; LUSC cis rs1368882 1.000 rs1368882 chr1:55107019 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.5 -8.12 -0.41 9.32e-15 Non-substance related behavioral disinhibition; LUSC cis rs9311676 0.656 rs62258134 chr3:58398447 C/T cg26110898 chr3:58419937 PDHB 0.4 6.42 0.33 4.6e-10 Systemic lupus erythematosus; LUSC cis rs2979489 0.580 rs73245347 chr8:30448213 T/G cg26383811 chr8:30366931 RBPMS -0.46 -7.39 -0.37 1.19e-12 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.79 0.6 1.44e-34 Platelet count; LUSC cis rs6582630 0.622 rs11182004 chr12:38441254 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.06e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs2204008 0.774 rs11514062 chr12:38332297 A/C cg06521331 chr12:34319734 NA -0.4 -6.21 -0.32 1.6e-9 Bladder cancer; LUSC cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg23158103 chr7:148848205 ZNF398 -0.44 -6.8 -0.35 4.78e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10750766 1 rs10750766 chr11:65473798 C/A cg21033440 chr11:65409861 SIPA1 0.38 5.8 0.3 1.57e-8 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs7312933 0.645 rs11181404 chr12:42683840 T/C cg01256987 chr12:42539512 GXYLT1 -0.42 -7.7 -0.39 1.56e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2762353 1.000 rs2762353 chr6:25794431 A/G cg03517284 chr6:25882590 NA -0.43 -7.73 -0.39 1.24e-13 Blood metabolite levels; LUSC trans rs6502050 0.769 rs9898292 chr17:80100345 A/T cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs2573652 1.000 rs2581362 chr15:100513524 T/C cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.38 -0.37 1.23e-12 Height; LUSC cis rs1891275 0.515 rs2153653 chr10:93495926 T/A cg07889827 chr10:93443413 NA -0.41 -9.28 -0.45 2.19e-18 Intelligence (multi-trait analysis); LUSC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.63 0.5 6.12e-23 Hip circumference adjusted for BMI; LUSC cis rs1003719 0.591 rs9636914 chr21:38589732 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.66 0.39 2.08e-13 Eye color traits; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg01171360 chr6:293285 DUSP22 -0.69 -11.24 -0.52 4.47e-25 Menopause (age at onset); LUSC trans rs73019876 0.869 rs10417673 chr19:22148101 A/T cg16204205 chr18:19753432 GATA6 0.33 6.32 0.33 8.2e-10 Testicular germ cell tumor; LUSC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg21854759 chr1:92012499 NA -0.53 -8.91 -0.44 3.34e-17 Breast cancer; LUSC cis rs8114671 0.662 rs3761143 chr20:33545745 C/T cg24642439 chr20:33292090 TP53INP2 0.43 6.26 0.32 1.2e-9 Height; LUSC cis rs4666002 0.789 rs13030973 chr2:27928797 T/C cg27432699 chr2:27873401 GPN1 0.5 6.54 0.34 2.34e-10 Phospholipid levels (plasma); LUSC cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -10.75 -0.51 2.32e-23 Chronic sinus infection; LUSC cis rs317689 0.600 rs478863 chr12:69639207 G/A cg20891283 chr12:69753455 YEATS4 0.44 5.82 0.3 1.38e-8 Response to diuretic therapy; LUSC cis rs7824557 0.564 rs2736301 chr8:11236413 C/T cg21775007 chr8:11205619 TDH -0.65 -10.36 -0.49 5.25e-22 Retinal vascular caliber; LUSC cis rs9467773 1.000 rs11756120 chr6:26529808 G/C cg09904177 chr6:26538194 HMGN4 0.76 14.41 0.62 5.82e-37 Intelligence (multi-trait analysis); LUSC cis rs17102423 0.963 rs35002541 chr14:65598704 G/A cg11161011 chr14:65562177 MAX -0.61 -9.45 -0.46 5.99e-19 Obesity-related traits; LUSC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.98 -0.31 5.82e-9 Tonsillectomy; LUSC cis rs11906854 0.636 rs3171389 chr20:34636281 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.08 -0.32 3.27e-9 Migraine - clinic-based; LUSC cis rs2404602 0.735 rs11637490 chr15:76759565 A/G cg23625390 chr15:77176239 SCAPER -0.61 -9.61 -0.47 1.82e-19 Blood metabolite levels; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg06675538 chr2:114033490 PAX8;LOC440839 -0.32 -5.85 -0.31 1.14e-8 Lymphocyte counts; LUSC cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg05283184 chr6:79620031 NA 0.57 12.15 0.55 2.21e-28 Intelligence (multi-trait analysis); LUSC cis rs453301 0.653 rs1562211 chr8:8902424 A/G cg15556689 chr8:8085844 FLJ10661 -0.69 -11.25 -0.52 3.95e-25 Joint mobility (Beighton score); LUSC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg17179660 chr6:151773299 C6orf211;RMND1 -0.4 -5.91 -0.31 8.65e-9 Menarche (age at onset); LUSC cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg17063962 chr7:91808500 NA 0.6 9.38 0.46 1.03e-18 Breast cancer; LUSC cis rs7408868 1.000 rs757475 chr19:15273749 C/T cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.1e-18 Pulse pressure; LUSC cis rs4662945 0.603 rs1453147 chr2:130271510 A/C cg05962382 chr2:130345044 NA -0.33 -5.65 -0.3 3.5e-8 Response to cytidine analogues (gemcitabine); LUSC trans rs1478897 0.898 rs2248932 chr8:11391650 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -6.37 -0.33 6.22e-10 Systemic lupus erythematosus; LUSC cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg13010199 chr12:38710504 ALG10B 0.66 10.22 0.49 1.67e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg11843238 chr5:131593191 PDLIM4 -0.39 -6.37 -0.33 6.18e-10 Breast cancer; LUSC cis rs4954585 0.762 rs12986776 chr2:136991517 C/G cg05194412 chr2:137003533 NA 0.4 7.35 0.37 1.5e-12 Colorectal cancer; LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.63 0.39 2.5e-13 Prudent dietary pattern; LUSC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC trans rs7618501 0.633 rs2856234 chr3:50139142 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -8.5 -0.42 6.18e-16 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg22532475 chr10:104410764 TRIM8 -0.33 -7.24 -0.37 3.03e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.75 0.35 6.52e-11 Systemic lupus erythematosus; LUSC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg16049864 chr8:95962084 TP53INP1 -0.64 -11.8 -0.54 4.42e-27 Type 2 diabetes; LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg26314531 chr2:26401878 FAM59B -0.68 -9.01 -0.44 1.56e-17 Gut microbiome composition (summer); LUSC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg20503657 chr10:835505 NA 0.83 11.25 0.52 3.97e-25 Eosinophil percentage of granulocytes; LUSC cis rs6961069 0.585 rs1949818 chr7:80237059 C/T cg04458919 chr7:80252533 CD36 -0.4 -7.27 -0.37 2.53e-12 Platelet count; LUSC cis rs116988415 0.584 rs4902309 chr14:65238171 A/G cg00114569 chr14:65239327 SPTB -0.66 -6.73 -0.35 7.55e-11 Daytime sleep phenotypes; LUSC cis rs4629180 0.586 rs1159902 chr2:102133641 G/A cg01388757 chr2:102091195 RFX8 -0.37 -6.43 -0.33 4.37e-10 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7072216 0.770 rs1061123 chr10:100176997 A/G cg26618903 chr10:100175079 PYROXD2 -0.35 -6.81 -0.35 4.66e-11 Metabolite levels; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg06600287 chr1:53387719 ECHDC2 0.32 6.33 0.33 7.97e-10 Monocyte count; LUSC cis rs4356932 1.000 rs4859415 chr4:76956528 A/G cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs9467773 1.000 rs28558133 chr6:26531433 G/C cg09904177 chr6:26538194 HMGN4 0.76 14.41 0.62 5.82e-37 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.52e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg06627628 chr2:24431161 ITSN2 -0.59 -7.24 -0.37 3.06e-12 Lymphocyte counts; LUSC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.57 -0.38 3.58e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.954 rs3890049 chr4:120326283 T/A cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg22532475 chr10:104410764 TRIM8 -0.35 -7.78 -0.39 9.35e-14 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7824557 0.701 rs4568582 chr8:11160495 A/T cg27411982 chr8:10470053 RP1L1 0.38 5.95 0.31 6.79e-9 Retinal vascular caliber; LUSC cis rs1595825 0.891 rs74265511 chr2:198494782 C/T cg00982548 chr2:198649783 BOLL -0.51 -6.38 -0.33 5.85e-10 Ulcerative colitis; LUSC cis rs7264396 0.635 rs2024854 chr20:34511189 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.94 -0.44 2.7e-17 Total cholesterol levels; LUSC cis rs17030434 1.000 rs6853522 chr4:154706220 A/C cg14289246 chr4:154710475 SFRP2 0.53 7.11 0.36 7.28e-12 Electrocardiographic conduction measures; LUSC cis rs2742417 0.603 rs1962800 chr3:45779943 C/T cg04837898 chr3:45731254 SACM1L -0.39 -6.35 -0.33 7.1e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2262909 0.962 rs12610034 chr19:22314528 G/A cg11619707 chr19:22235551 ZNF257 0.39 5.92 0.31 7.9e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs6456156 0.819 rs7765739 chr6:167518472 C/T cg07741184 chr6:167504864 NA 0.37 6.45 0.33 3.82e-10 Primary biliary cholangitis; LUSC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg18165381 chr3:44552316 NA -0.37 -5.87 -0.31 1.04e-8 Depressive symptoms; LUSC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.93 0.35 2.24e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg14196790 chr5:131705035 SLC22A5 0.42 6.78 0.35 5.61e-11 Breast cancer;Mosquito bite size; LUSC cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.83 -0.43 6.12e-17 Monocyte percentage of white cells; LUSC cis rs17401966 0.931 rs3748577 chr1:10357406 C/T cg19773385 chr1:10388646 KIF1B 0.58 9.83 0.47 3.48e-20 Hepatocellular carcinoma; LUSC cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg11050988 chr7:1952600 MAD1L1 -0.31 -5.95 -0.31 6.93e-9 Bipolar disorder and schizophrenia; LUSC trans rs8073060 0.614 rs225275 chr17:33972567 G/C cg19694781 chr19:47549865 TMEM160 -1.14 -17.81 -0.7 2.27e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg06634786 chr22:41940651 POLR3H 0.48 5.85 0.3 1.17e-8 Vitiligo; LUSC cis rs1048238 0.506 rs698890 chr1:16267371 C/G cg22431228 chr1:16359049 CLCNKA 0.4 8.34 0.42 1.93e-15 Systolic blood pressure; LUSC cis rs72792276 1.000 rs72794361 chr5:127435188 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.92 7.82 0.39 7.2e-14 Red cell distribution width; LUSC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg06454157 chr6:167490870 NA -0.25 -6.06 -0.31 3.71e-9 Crohn's disease; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg23281280 chr6:28129359 ZNF389 0.49 6.35 0.33 7.06e-10 Parkinson's disease; LUSC cis rs7267979 0.966 rs454723 chr20:25438928 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC trans rs28647808 0.748 rs28502181 chr9:136257792 T/G cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs41271473 0.948 rs12082771 chr1:228830777 C/T cg10167378 chr1:228756711 NA 0.63 7.67 0.39 1.84e-13 Chronic lymphocytic leukemia; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.28 6.02 0.31 4.49e-9 Electroencephalogram traits; LUSC cis rs34779708 0.966 rs1057108 chr10:35484949 T/G cg04310649 chr10:35416472 CREM -0.4 -6.21 -0.32 1.58e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs977987 0.843 rs4146810 chr16:75415831 A/G cg04384234 chr16:75411784 CFDP1 -0.44 -7.38 -0.37 1.25e-12 Dupuytren's disease; LUSC cis rs4319547 0.695 rs113841747 chr12:122886088 G/T cg23029597 chr12:123009494 RSRC2 0.75 9.55 0.46 2.84e-19 Body mass index; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17088247 chr6:28048961 ZNF165 -0.42 -6.2 -0.32 1.71e-9 Electrocardiographic conduction measures; LUSC cis rs10779751 0.770 rs2261434 chr1:11170131 A/C cg08854313 chr1:11322531 MTOR 0.85 13.82 0.6 1.1e-34 Body mass index; LUSC trans rs61931739 0.500 rs11053203 chr12:34456593 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.81 0.51 1.49e-23 Morning vs. evening chronotype; LUSC trans rs895636 0.898 rs10205310 chr2:45188646 A/G cg03867797 chr12:110939833 VPS29;RAD9B 0.49 6.26 0.32 1.17e-9 Metabolite levels;Fasting plasma glucose; LUSC cis rs9916302 0.706 rs4795385 chr17:37733148 A/G cg07936489 chr17:37558343 FBXL20 0.81 9.86 0.47 2.7e-20 Glomerular filtration rate (creatinine); LUSC cis rs2361710 0.669 rs12940486 chr17:78118569 T/C cg09238746 chr17:78121135 EIF4A3 -0.65 -10.13 -0.48 3.28e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs72700829 0.593 rs4418603 chr1:150989274 A/G cg11822372 chr1:151115635 SEMA6C -0.75 -6.7 -0.34 9e-11 Schizophrenia; LUSC cis rs72634258 0.945 rs17367289 chr1:8053135 C/T cg00042356 chr1:8021962 PARK7 -0.59 -8.15 -0.41 7.28e-15 Inflammatory bowel disease; LUSC cis rs478304 0.934 rs574483 chr11:65515277 A/G cg05805236 chr11:65401703 PCNXL3 0.4 6.84 0.35 3.82e-11 Acne (severe); LUSC cis rs1577917 0.681 rs4348284 chr6:86350394 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -7.56 -0.38 3.95e-13 Response to antipsychotic treatment; LUSC cis rs7605827 0.930 rs2111451 chr2:15654483 T/C cg19274914 chr2:15703543 NA 0.45 8.56 0.42 4.19e-16 Educational attainment (years of education); LUSC cis rs7189233 0.550 rs9938788 chr16:53481422 G/C cg09728985 chr16:53543985 NA -0.31 -5.86 -0.31 1.14e-8 Intelligence (multi-trait analysis); LUSC cis rs7681440 1.000 rs1471483 chr4:90754292 A/G cg01966878 chr4:90757139 SNCA -0.36 -6.24 -0.32 1.31e-9 Dementia with Lewy bodies; LUSC cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg05985134 chr18:33552581 C18orf21 0.51 7.05 0.36 1.01e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.25 0.37 3e-12 Platelet count; LUSC cis rs734999 0.933 rs4648648 chr1:2512452 G/A cg18854424 chr1:2615690 NA 0.49 10.38 0.49 4.55e-22 Ulcerative colitis; LUSC trans rs11148252 0.595 rs9526968 chr13:53240183 T/C cg18335740 chr13:41363409 SLC25A15 0.76 13.53 0.6 1.44e-33 Lewy body disease; LUSC cis rs3812111 0.510 rs9372456 chr6:116592956 A/G cg18828861 chr6:116576566 TSPYL4 0.38 6.72 0.35 7.97e-11 Age-related macular degeneration; LUSC cis rs4919687 0.550 rs17784294 chr10:104479385 G/T cg05855489 chr10:104503620 C10orf26 0.71 11.7 0.54 9.47e-27 Colorectal cancer; LUSC cis rs9837602 1.000 rs793499 chr3:99565576 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 5.86 0.31 1.13e-8 Breast cancer; LUSC cis rs7241530 0.662 rs8088204 chr18:75901055 C/T cg14642773 chr18:75888474 NA 0.4 6.08 0.32 3.37e-9 Educational attainment (years of education); LUSC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg24110177 chr3:50126178 RBM5 -0.55 -9.1 -0.45 8.15e-18 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 6.83 0.35 3.98e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.85 0.6 8.65e-35 Chronic sinus infection; LUSC cis rs2479724 0.901 rs10947987 chr6:41754370 C/T cg17623882 chr6:41773611 USP49 0.67 10.63 0.5 6.17e-23 Menarche (age at onset); LUSC cis rs11711311 1.000 rs9811353 chr3:113483979 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 7.13 0.36 6.3e-12 IgG glycosylation; LUSC cis rs9311676 0.656 rs12497250 chr3:58399399 T/C cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg10523860 chr14:103875565 MARK3 -0.37 -5.82 -0.3 1.35e-8 Body mass index; LUSC cis rs1729951 0.575 rs10935213 chr3:136693459 A/G cg21827317 chr3:136751795 NA 0.39 6.93 0.35 2.23e-11 Neuroticism; LUSC cis rs2439831 0.867 rs6493082 chr15:43634808 C/T cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs1401999 0.668 rs6806313 chr3:183642152 G/C cg05044414 chr3:183734942 ABCC5 0.2 7.02 0.36 1.27e-11 Anterior chamber depth; LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg08280861 chr8:58055591 NA 0.52 6.81 0.35 4.54e-11 Developmental language disorder (linguistic errors); LUSC cis rs478304 0.654 rs11601509 chr11:65456864 T/C cg05805236 chr11:65401703 PCNXL3 -0.63 -10.33 -0.49 6.71e-22 Acne (severe); LUSC cis rs4664308 0.935 rs4665148 chr2:160917901 A/G cg03641300 chr2:160917029 PLA2R1 -0.68 -11.31 -0.53 2.55e-25 Idiopathic membranous nephropathy; LUSC cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg11266682 chr4:10021025 SLC2A9 -0.46 -7.63 -0.39 2.49e-13 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs11098499 0.863 rs7664986 chr4:120429952 A/C cg25214090 chr10:38739885 LOC399744 0.5 7.39 0.37 1.19e-12 Corneal astigmatism; LUSC cis rs7707921 1.000 rs749401 chr5:81561369 T/C cg15871215 chr5:81402204 ATG10 -0.43 -6.24 -0.32 1.3e-9 Breast cancer; LUSC cis rs75804782 0.641 rs55844289 chr2:239323207 C/T cg18131467 chr2:239335373 ASB1 -0.71 -6.47 -0.33 3.41e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs929596 0.606 rs7604115 chr2:234658116 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.62 -10.37 -0.49 4.97e-22 Total bilirubin levels in HIV-1 infection; LUSC cis rs477692 0.685 rs551491 chr10:131397821 G/A cg11019008 chr10:131425282 MGMT 0.45 6.61 0.34 1.52e-10 Response to temozolomide; LUSC cis rs748404 0.604 rs2278857 chr15:43632549 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.36 0.42 1.7e-15 Lung cancer; LUSC cis rs2274273 0.870 rs4496026 chr14:55790512 A/G cg04306507 chr14:55594613 LGALS3 0.54 11.81 0.54 3.98e-27 Protein biomarker; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20428342 chr10:102820768 KAZALD1 -0.4 -5.98 -0.31 5.8e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7592578 0.771 rs12053190 chr2:191383348 A/G cg11845111 chr2:191398756 TMEM194B -0.87 -11.22 -0.52 5.25e-25 Diastolic blood pressure; LUSC cis rs7178572 0.568 rs7175674 chr15:77670910 C/T cg22256960 chr15:77711686 NA -0.51 -8.09 -0.4 1.11e-14 Type 2 diabetes; LUSC cis rs9395066 0.545 rs10484627 chr6:44884267 A/T cg25276700 chr6:44698697 NA 0.3 6.12 0.32 2.63e-9 Height; LUSC cis rs9287719 0.967 rs7566767 chr2:10754663 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC trans rs7647973 0.626 rs1996663 chr3:49878264 C/G cg21659725 chr3:3221576 CRBN 0.69 7.99 0.4 2.28e-14 Menarche (age at onset); LUSC cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg24642439 chr20:33292090 TP53INP2 0.72 11.82 0.54 3.51e-27 Coronary artery disease; LUSC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg06634786 chr22:41940651 POLR3H 0.52 6.16 0.32 2.11e-9 Vitiligo; LUSC cis rs13082711 0.911 rs3816881 chr3:27432888 T/C cg02860705 chr3:27208620 NA 0.46 7.66 0.39 2e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg21573476 chr21:45109991 RRP1B -0.42 -6.75 -0.35 6.5500000000000006e-11 Mean corpuscular volume; LUSC trans rs7944735 0.567 rs76477746 chr11:48103368 G/C cg15704280 chr7:45808275 SEPT13 0.71 5.96 0.31 6.48e-9 Intraocular pressure; LUSC trans rs11039798 0.623 rs594615 chr11:48402804 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -7.1 -0.36 7.73e-12 Axial length; LUSC trans rs7980799 0.682 rs10844611 chr12:33603544 T/C cg26384229 chr12:38710491 ALG10B -0.59 -8.84 -0.44 5.5e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs2840044 1.000 rs1671656 chr17:33939661 C/T cg19694781 chr19:47549865 TMEM160 -0.59 -9.41 -0.46 8.5e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg26314531 chr2:26401878 FAM59B -0.69 -9.28 -0.45 2.12e-18 Gut microbiome composition (summer); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg03988675 chr1:14075428 PRDM2 -0.37 -6.13 -0.32 2.41e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7249142 0.549 rs62135499 chr19:19294237 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.53 8.97 0.44 2.23e-17 IgG glycosylation; LUSC cis rs7223966 1.000 rs8076717 chr17:61850301 C/T cg05941027 chr17:61774174 LIMD2 -0.22 -5.82 -0.3 1.36e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg06713675 chr4:122721982 EXOSC9 -0.69 -12.02 -0.55 6.45e-28 Type 2 diabetes; LUSC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg04414720 chr1:150670196 GOLPH3L 0.5 7.76 0.39 1.07e-13 Melanoma; LUSC trans rs1005277 0.579 rs1548255 chr10:38417193 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.65 -0.47 1.39e-19 Extrinsic epigenetic age acceleration; LUSC cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg21535247 chr6:8435926 SLC35B3 -0.56 -8.6 -0.43 3.16e-16 Motion sickness; LUSC cis rs9549367 0.789 rs9549705 chr13:113888425 T/C cg00898013 chr13:113819073 PROZ -0.58 -8.36 -0.42 1.76e-15 Platelet distribution width; LUSC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg08677398 chr8:58056175 NA 0.5 5.83 0.3 1.28e-8 Developmental language disorder (linguistic errors); LUSC cis rs7804356 1.000 rs3801821 chr7:26861206 C/T cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs6570726 0.533 rs1832374 chr6:145717752 A/G cg23711669 chr6:146136114 FBXO30 0.46 7.08 0.36 8.66e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2289583 0.597 rs12148708 chr15:75384397 G/A cg14664628 chr15:75095509 CSK 0.44 6.27 0.32 1.1e-9 Systemic lupus erythematosus; LUSC cis rs614226 0.744 rs787832 chr12:120986801 A/G cg01236616 chr12:121019343 POP5 1.31 21.44 0.76 9.83e-65 Type 1 diabetes nephropathy; LUSC cis rs1461503 0.932 rs6589962 chr11:122843535 G/A cg27398637 chr11:122830231 C11orf63 -0.4 -6.5 -0.34 2.93e-10 Menarche (age at onset); LUSC cis rs8058578 0.943 rs7197770 chr16:30715908 T/C cg02466173 chr16:30829666 NA -0.59 -10.83 -0.51 1.28e-23 Multiple myeloma; LUSC cis rs1003719 0.788 rs7275582 chr21:38451130 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.18 0.52 7.29e-25 Eye color traits; LUSC trans rs1005277 0.579 rs1780133 chr10:38499509 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.5 -0.46 4.14e-19 Extrinsic epigenetic age acceleration; LUSC cis rs28655083 0.828 rs7190227 chr16:77119568 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.52 7.75 0.39 1.13e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg03646922 chr17:4167316 ANKFY1 0.39 6.24 0.32 1.36e-9 Calcium levels; LUSC cis rs1395 0.744 rs11126929 chr2:27472027 C/T cg23587288 chr2:27483067 SLC30A3 0.3 5.86 0.31 1.13e-8 Blood metabolite levels; LUSC cis rs34779708 0.966 rs1057108 chr10:35484949 T/G cg03585969 chr10:35415529 CREM 0.64 9.54 0.46 3.08e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg07507251 chr3:52567010 NT5DC2 0.34 6.45 0.33 4e-10 Bipolar disorder; LUSC trans rs656319 0.580 rs17690549 chr8:9998538 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.63 -0.39 2.47e-13 Myopia (pathological); LUSC cis rs11122272 0.735 rs973252 chr1:231520802 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg24578937 chr1:2090814 PRKCZ -0.44 -9.61 -0.47 1.78e-19 Height; LUSC cis rs1728785 1.000 rs1170442 chr16:68574064 G/T cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC cis rs644148 0.738 rs2686768 chr19:44995990 C/T cg15540054 chr19:45004280 ZNF180 -0.5 -7.02 -0.36 1.26e-11 Personality dimensions; LUSC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg03609598 chr5:56110824 MAP3K1 -0.41 -6.15 -0.32 2.21e-9 Initial pursuit acceleration; LUSC cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14240646 chr10:27532245 ACBD5 -0.71 -7.65 -0.39 2.13e-13 Breast cancer; LUSC cis rs826838 0.616 rs10880754 chr12:38628154 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.76 -0.35 6.24e-11 Heart rate; LUSC trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg13615516 chr5:77269221 NA 0.4 6.76 0.35 6.09e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs11758351 1.000 rs79868973 chr6:26189312 C/G cg23601095 chr6:26197514 HIST1H3D 0.73 7.97 0.4 2.52e-14 Gout;Renal underexcretion gout; LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg00149659 chr3:10157352 C3orf10 -0.95 -14.2 -0.61 3.76e-36 Alzheimer's disease; LUSC cis rs11645898 0.688 rs437638 chr16:72095452 C/T cg14768367 chr16:72042858 DHODH -0.73 -7.93 -0.4 3.22e-14 Blood protein levels; LUSC cis rs1577917 1.000 rs12664335 chr6:86597774 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.62 8.7 0.43 1.5e-16 Response to antipsychotic treatment; LUSC cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg09876464 chr15:85330779 ZNF592 0.36 6.85 0.35 3.5e-11 P wave terminal force; LUSC cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg11890956 chr21:40555474 PSMG1 0.7 11.13 0.52 1.11e-24 Cognitive function; LUSC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg06808227 chr14:105710500 BRF1 -0.69 -10.97 -0.51 4.19e-24 Mean platelet volume;Platelet distribution width; LUSC cis rs3126085 0.825 rs7535078 chr1:152222915 T/C cg26876637 chr1:152193138 HRNR 0.44 6.35 0.33 7.09e-10 Atopic dermatitis; LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg25767906 chr1:53392781 SCP2 0.49 8.74 0.43 1.13e-16 Monocyte count; LUSC cis rs950169 0.723 rs17589320 chr15:84919996 C/A cg12863693 chr15:85201151 NMB 0.36 7.15 0.36 5.61e-12 Schizophrenia; LUSC cis rs11098499 0.697 rs28458294 chr4:120238924 T/C cg24375607 chr4:120327624 NA 0.76 11.87 0.54 2.32e-27 Corneal astigmatism; LUSC cis rs12210905 0.687 rs12191649 chr6:27421208 A/T cg08851530 chr6:28072375 NA 0.93 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI; LUSC cis rs500891 0.525 rs7768550 chr6:84075810 T/G cg08257003 chr6:84140564 ME1 0.34 8.16 0.41 6.84e-15 Platelet-derived growth factor BB levels; LUSC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg13390004 chr1:15929781 NA 0.4 6.68 0.34 1e-10 Systolic blood pressure; LUSC cis rs2806561 0.765 rs679591 chr1:23499916 T/C cg19743168 chr1:23544995 NA 0.43 8.21 0.41 4.9e-15 Height; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16109953 chr14:24701739 GMPR2;NEDD8 0.49 6.74 0.35 6.83e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs853679 0.546 rs34371502 chr6:28081758 T/C cg01620082 chr3:125678407 NA -0.85 -7.28 -0.37 2.42e-12 Depression; LUSC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg04998671 chr14:104000505 TRMT61A -0.42 -6.0 -0.31 5e-9 Reticulocyte count; LUSC cis rs826838 0.651 rs12367384 chr12:38618460 G/T cg13010199 chr12:38710504 ALG10B 0.59 8.84 0.44 5.46e-17 Heart rate; LUSC cis rs2425143 0.598 rs2425118 chr20:34324098 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.38 -0.42 1.49e-15 Blood protein levels; LUSC cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.33 -6.01 -0.31 4.75e-9 IgG glycosylation; LUSC cis rs10464366 0.879 rs10464368 chr7:39121581 C/T cg15212455 chr7:39170539 POU6F2 0.38 5.97 0.31 5.92e-9 IgG glycosylation; LUSC trans rs7739264 0.602 rs1121384 chr6:19771507 A/G cg13431028 chr2:169073609 STK39 0.38 6.39 0.33 5.62e-10 Endometriosis; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.79 0.6 1.47e-34 Alzheimer's disease; LUSC cis rs1865721 0.771 rs7231277 chr18:73136724 A/G cg26385618 chr18:73139727 C18orf62 -0.55 -10.1 -0.48 4.25e-21 Intelligence; LUSC cis rs2282526 0.615 rs162377 chr21:44926001 A/G cg04455712 chr21:45112962 RRP1B 0.43 7.39 0.38 1.16e-12 Mean corpuscular hemoglobin; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg14893161 chr1:205819251 PM20D1 0.89 17.69 0.7 7.09e-50 Menarche (age at onset); LUSC cis rs9393692 0.627 rs2179517 chr6:26198845 G/C cg00631329 chr6:26305371 NA -0.34 -6.31 -0.33 8.7e-10 Educational attainment; LUSC cis rs2486288 0.656 rs11854365 chr15:45558083 G/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.0 -0.4 2.14e-14 Glomerular filtration rate; LUSC cis rs4654899 0.897 rs59537090 chr1:21498737 C/T cg01072550 chr1:21505969 NA -0.55 -8.49 -0.42 7e-16 Superior frontal gyrus grey matter volume; LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg10802521 chr3:52805072 NEK4 -0.47 -7.46 -0.38 7.66e-13 Electroencephalogram traits; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.31 0.41 2.4e-15 Prudent dietary pattern; LUSC cis rs6060717 0.536 rs8125966 chr20:34511823 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.74 -0.3 2.13e-8 Hip circumference adjusted for BMI; LUSC cis rs6138458 0.887 rs227622 chr20:24910597 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.1 0.7 1.58e-51 Blood protein levels; LUSC cis rs17818399 0.597 rs13385693 chr2:46867158 C/T cg21493583 chr2:46842958 PIGF;CRIPT 0.34 6.12 0.32 2.69e-9 Height; LUSC cis rs7824557 0.564 rs7821459 chr8:11236681 T/G cg21775007 chr8:11205619 TDH -0.65 -10.36 -0.49 5.25e-22 Retinal vascular caliber; LUSC cis rs7954584 0.567 rs11612028 chr12:122387872 C/G cg21016266 chr12:122356598 WDR66 0.62 9.42 0.46 7.45e-19 Mean corpuscular volume; LUSC trans rs9886428 1.000 rs34062482 chr8:14115734 A/C cg11959399 chr20:741723 C20orf54 -0.42 -6.66 -0.34 1.14e-10 IgG glycosylation; LUSC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.48 -7.72 -0.39 1.33e-13 Alzheimer's disease (late onset); LUSC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.35 -5.75 -0.3 2.04e-8 Total body bone mineral density; LUSC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg20406979 chr6:167373233 NA 0.25 5.96 0.31 6.39e-9 Crohn's disease; LUSC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.77 7.67 0.39 1.91e-13 Initial pursuit acceleration; LUSC cis rs11585357 0.947 rs6684387 chr1:17611519 T/C cg08277548 chr1:17600880 PADI3 0.63 6.8 0.35 4.74e-11 Hair shape; LUSC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg03452623 chr4:187889614 NA -0.88 -18.62 -0.71 1.43e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs11158026 0.518 rs878944 chr14:55443602 A/G cg04306507 chr14:55594613 LGALS3 0.38 6.37 0.33 6.41e-10 Parkinson's disease; LUSC cis rs4595586 0.545 rs7307303 chr12:39368976 A/G cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.56e-11 Morning vs. evening chronotype; LUSC cis rs1507153 0.775 rs12210702 chr6:79369333 A/G cg05283184 chr6:79620031 NA -0.43 -7.63 -0.39 2.42e-13 Sjögren's syndrome; LUSC cis rs4478137 0.501 rs9764 chr4:164245405 A/G cg06758707 chr4:164254230 NPY1R -0.51 -6.85 -0.35 3.58e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs4423214 0.610 rs12793607 chr11:71129316 C/T cg05163923 chr11:71159392 DHCR7 -0.52 -7.79 -0.39 8.39e-14 Vitamin D levels; LUSC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg19230755 chr7:65878503 NA -0.38 -5.74 -0.3 2.17e-8 Aortic root size; LUSC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg18230493 chr5:56204884 C5orf35 -0.66 -9.94 -0.48 1.5e-20 Coronary artery disease; LUSC cis rs67478160 0.634 rs7141928 chr14:104219949 C/T cg01849466 chr14:104193079 ZFYVE21 -0.62 -10.4 -0.49 4.07e-22 Schizophrenia; LUSC cis rs2762353 0.526 rs9461203 chr6:25710555 C/T cg16482183 chr6:26056742 HIST1H1C -0.41 -5.83 -0.3 1.3e-8 Blood metabolite levels; LUSC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg20908204 chr19:46285434 DMPK 0.41 8.18 0.41 6.07e-15 Coronary artery disease; LUSC cis rs10911232 0.507 rs10911231 chr1:183051745 T/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Hypertriglyceridemia; LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg27535305 chr1:53392650 SCP2 -0.48 -9.36 -0.46 1.21e-18 Monocyte count; LUSC cis rs34779708 0.931 rs35136660 chr10:35385973 C/A cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3782089 1.000 rs11600543 chr11:65298939 G/A cg00206168 chr11:65308501 LTBP3 1.32 8.84 0.44 5.6e-17 Height; LUSC cis rs1403694 0.695 rs13095338 chr3:186435583 T/C cg12454167 chr3:186435060 KNG1 0.33 8.17 0.41 6.57e-15 Blood protein levels; LUSC cis rs6009527 0.752 rs7286232 chr22:49568490 A/G cg12746016 chr22:49560550 NA 0.48 8.74 0.43 1.19e-16 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01485046 chr19:46498389 CCDC61 -0.4 -5.99 -0.31 5.53e-9 Electrocardiographic conduction measures; LUSC cis rs10791323 0.569 rs546381 chr11:133760651 T/G cg15485101 chr11:133734466 NA 0.39 7.13 0.36 6.18e-12 Childhood ear infection; LUSC cis rs7614311 0.636 rs73117041 chr3:63896266 A/T cg22134162 chr3:63841271 THOC7 -0.49 -6.17 -0.32 1.95e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg15103426 chr22:29168792 CCDC117 -0.44 -5.66 -0.3 3.26e-8 Lymphocyte counts; LUSC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg12560992 chr17:57184187 TRIM37 -0.83 -15.13 -0.64 9.27e-40 Intelligence (multi-trait analysis); LUSC cis rs10887741 0.690 rs11202503 chr10:89440749 T/G cg24243914 chr10:89418206 PAPSS2 0.34 6.72 0.35 7.86e-11 Exercise (leisure time); LUSC cis rs12760731 0.565 rs35038893 chr1:178168417 C/T cg00404053 chr1:178313656 RASAL2 0.66 6.82 0.35 4.26e-11 Obesity-related traits; LUSC cis rs10089 1.000 rs9968597 chr5:127455383 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.08 0.55 4.06e-28 Ileal carcinoids; LUSC cis rs6500395 0.832 rs8052733 chr16:48691978 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13012494 chr21:47604986 C21orf56 0.47 7.04 0.36 1.11e-11 Testicular germ cell tumor; LUSC cis rs1153858 1.000 rs2461701 chr15:45703391 G/A cg26924012 chr15:45694286 SPATA5L1 1.1 19.11 0.72 1.62e-55 Homoarginine levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08857478 chr17:74722826 JMJD6;C17orf95 0.41 6.44 0.33 4.25e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7937682 0.889 rs11213969 chr11:111528441 A/G cg09085632 chr11:111637200 PPP2R1B -1.09 -17.73 -0.7 4.82e-50 Primary sclerosing cholangitis; LUSC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg08677398 chr8:58056175 NA -0.52 -6.85 -0.35 3.5e-11 Developmental language disorder (linguistic errors); LUSC cis rs4478858 0.709 rs7514640 chr1:31752316 G/A cg00250761 chr1:31883323 NA -0.34 -8.15 -0.41 7.26e-15 Alcohol dependence; LUSC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg18512352 chr11:47633146 NA -0.48 -9.73 -0.47 7.1e-20 Subjective well-being; LUSC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.36 0.53 1.6e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg21854759 chr1:92012499 NA 0.51 8.57 0.42 4.02e-16 Breast cancer; LUSC cis rs780094 0.585 rs7586601 chr2:27584666 A/G cg27432699 chr2:27873401 GPN1 -0.51 -7.63 -0.39 2.43e-13 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs782590 0.818 rs2627782 chr2:55825352 A/G cg18811423 chr2:55921094 PNPT1 0.77 12.76 0.57 1.2e-30 Metabolic syndrome; LUSC cis rs6500395 1.000 rs1486412 chr16:48651750 A/T cg04672837 chr16:48644449 N4BP1 0.48 6.98 0.36 1.56e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7589342 0.831 rs34554853 chr2:106448931 G/A cg14210321 chr2:106509881 NCK2 -0.54 -8.16 -0.41 7.13e-15 Addiction; LUSC cis rs9326248 0.520 rs2735183 chr11:117015195 C/T cg01368799 chr11:117014884 PAFAH1B2 0.66 10.61 0.5 7.66e-23 Blood protein levels; LUSC cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.16 0.49 2.61e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs41271473 1.000 rs11587994 chr1:228860072 A/C cg16512390 chr1:228756714 NA 0.55 6.56 0.34 2.08e-10 Chronic lymphocytic leukemia; LUSC cis rs56399783 0.614 rs55776032 chr7:2762255 T/C cg19731401 chr7:2775893 GNA12 0.73 8.59 0.43 3.46e-16 Childhood ear infection; LUSC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg21132104 chr15:45694354 SPATA5L1 -0.64 -9.19 -0.45 4.28e-18 Homoarginine levels; LUSC cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg03517284 chr6:25882590 NA -0.52 -9.71 -0.47 8.33e-20 Blood metabolite levels; LUSC cis rs2486288 0.656 rs12908818 chr15:45571668 A/G cg09092052 chr15:45571596 NA 0.46 6.34 0.33 7.51e-10 Glomerular filtration rate; LUSC cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg06064525 chr11:970664 AP2A2 -0.29 -5.83 -0.3 1.33e-8 Alzheimer's disease (late onset); LUSC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.897 rs7572509 chr2:15597288 C/T cg19274914 chr2:15703543 NA 0.45 8.52 0.42 5.61e-16 Educational attainment (years of education); LUSC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg13395646 chr4:1353034 KIAA1530 -0.55 -8.69 -0.43 1.64e-16 Obesity-related traits; LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg20295408 chr7:1910781 MAD1L1 -0.45 -6.34 -0.33 7.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.79 0.57 9.25e-31 Platelet count; LUSC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg15839431 chr19:19639596 YJEFN3 -0.63 -7.11 -0.36 7.15e-12 Bipolar disorder; LUSC cis rs6582630 0.563 rs923281 chr12:38590241 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.45 -0.42 9.13e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs11971779 0.680 rs4398844 chr7:139043139 G/A cg23387468 chr7:139079360 LUC7L2 0.42 6.35 0.33 7.03e-10 Diisocyanate-induced asthma; LUSC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg09904177 chr6:26538194 HMGN4 -0.39 -5.71 -0.3 2.52e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs73206853 0.614 rs57154770 chr12:110814415 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.28 0.32 1.08e-9 Height; LUSC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg22800045 chr5:56110881 MAP3K1 0.79 10.02 0.48 7.93e-21 Initial pursuit acceleration; LUSC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg06671706 chr8:8559999 CLDN23 0.45 6.33 0.33 7.81e-10 Obesity-related traits; LUSC cis rs2204008 0.744 rs11181337 chr12:38322083 C/A cg13010199 chr12:38710504 ALG10B 0.61 9.44 0.46 6.49e-19 Bladder cancer; LUSC cis rs6665290 0.836 rs12593 chr1:227172290 A/G cg10327440 chr1:227177885 CDC42BPA 1.2 35.99 0.89 5.4800000000000004e-117 Myeloid white cell count; LUSC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg01579765 chr21:45077557 HSF2BP -0.54 -11.5 -0.53 5.31e-26 Mean corpuscular volume; LUSC cis rs6547741 1.000 rs6547740 chr2:27854369 C/T cg27432699 chr2:27873401 GPN1 0.71 11.94 0.55 1.33e-27 Oral cavity cancer; LUSC cis rs921968 0.643 rs4674321 chr2:219511368 G/A cg02176678 chr2:219576539 TTLL4 0.6 11.19 0.52 6.86e-25 Mean corpuscular hemoglobin concentration; LUSC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg19077165 chr18:44547161 KATNAL2 0.41 6.3 0.33 9.21e-10 Personality dimensions; LUSC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg16339924 chr4:17578868 LAP3 0.53 8.24 0.41 4.02e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9303401 0.659 rs62081314 chr17:56778328 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.57 0.6 1e-33 Cognitive test performance; LUSC cis rs11098499 0.863 rs13134665 chr4:120426430 T/C cg09307838 chr4:120376055 NA 0.75 11.0 0.52 3.27e-24 Corneal astigmatism; LUSC cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg22681709 chr2:178499509 PDE11A 0.48 8.56 0.42 4.18e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs9929218 0.954 rs112225541 chr16:68755165 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -12.43 -0.56 2.12e-29 Colorectal cancer; LUSC cis rs4319547 0.695 rs10846699 chr12:122853073 A/G cg23029597 chr12:123009494 RSRC2 0.74 9.66 0.47 1.24e-19 Body mass index; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17133724 chr18:22932450 ZNF521 0.72 6.3 0.33 9.58e-10 Cognitive performance; LUSC trans rs11098499 0.863 rs7664986 chr4:120429952 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.61 0.34 1.48e-10 Corneal astigmatism; LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg03579872 chr1:53393473 SCP2 -0.39 -5.78 -0.3 1.74e-8 Monocyte count; LUSC cis rs10266483 0.774 rs10239221 chr7:63813230 G/A cg24201672 chr7:64023550 ZNF680 0.45 5.86 0.31 1.11e-8 Response to statin therapy; LUSC cis rs11190604 0.673 rs10883498 chr10:102228709 T/A cg16342193 chr10:102329863 NA -0.35 -6.28 -0.32 1.08e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2303282 0.716 rs2920702 chr16:56461511 C/G cg00500540 chr16:56394104 NA -0.43 -7.35 -0.37 1.52e-12 Breast cancer; LUSC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg23630131 chr7:65973040 NA 0.21 5.78 0.3 1.76e-8 Aortic root size; LUSC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg22963979 chr7:1858916 MAD1L1 -0.59 -9.4 -0.46 8.96e-19 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.863 rs10004484 chr4:120442428 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.64 0.39 2.36e-13 Corneal astigmatism; LUSC cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg25643088 chr3:52874325 TMEM110 0.39 6.0 0.31 5.11e-9 Schizophrenia; LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -8.73 -0.43 1.27e-16 Bipolar disorder and schizophrenia; LUSC cis rs965469 0.779 rs6037516 chr20:3233142 C/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.65 -0.3 3.46e-8 IFN-related cytopenia; LUSC cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg06627628 chr2:24431161 ITSN2 -0.89 -13.18 -0.58 3.29e-32 Asthma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22717607 chr5:10353969 MARCH6 -0.46 -6.1 -0.32 2.94e-9 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.41 -0.33 5.01e-10 Lung cancer; LUSC cis rs9300255 0.602 rs1727315 chr12:123638930 A/G cg05973401 chr12:123451056 ABCB9 -0.54 -6.77 -0.35 5.72e-11 Neutrophil percentage of white cells; LUSC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.52 -0.42 5.73e-16 Lung cancer; LUSC trans rs9329221 0.698 rs35388602 chr8:10259188 T/C cg15556689 chr8:8085844 FLJ10661 0.54 7.44 0.38 8.52e-13 Neuroticism; LUSC cis rs6430585 0.527 rs1438303 chr2:136429857 C/T cg07169764 chr2:136633963 MCM6 1.04 13.85 0.6 8.62e-35 Corneal structure; LUSC cis rs2191566 0.664 rs7255512 chr19:44574700 C/T cg03039196 chr19:44506973 ZNF230 0.35 5.82 0.3 1.4e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg05347473 chr6:146136440 FBXO30 -0.47 -7.97 -0.4 2.54e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg08125733 chr17:73851984 WBP2 0.46 6.44 0.33 4.14e-10 White matter hyperintensity burden; LUSC cis rs11190604 1.000 rs74650218 chr10:102293830 C/T cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6940638 0.956 rs10946899 chr6:27023694 T/A cg09904177 chr6:26538194 HMGN4 -0.51 -6.41 -0.33 5.08e-10 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.81 0.39 7.4e-14 Bipolar disorder; LUSC cis rs12681287 0.927 rs7003059 chr8:87330713 C/T cg27223183 chr8:87520930 FAM82B -0.45 -6.0 -0.31 5.24e-9 Caudate activity during reward; LUSC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg13531842 chr10:38383804 ZNF37A -0.48 -7.42 -0.38 9.51e-13 Extrinsic epigenetic age acceleration; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg07167872 chr1:205819463 PM20D1 -0.74 -14.77 -0.63 2.42e-38 Monocyte percentage of white cells; LUSC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg04111992 chr7:158790115 NA -0.37 -5.94 -0.31 7.35e-9 Facial morphology (factor 20); LUSC cis rs7577851 0.669 rs72826571 chr2:69564580 A/G cg10773587 chr2:69614142 GFPT1 0.58 6.2 0.32 1.67e-9 Parkinson's disease (age of onset); LUSC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg01073479 chr16:3509474 NAT15 -0.31 -5.91 -0.31 8.21e-9 Tuberculosis; LUSC cis rs394563 0.591 rs6570964 chr6:149691859 G/A cg07828024 chr6:149772892 ZC3H12D 0.34 7.32 0.37 1.9e-12 Dupuytren's disease; LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg00684032 chr4:1343700 KIAA1530 0.34 5.85 0.3 1.2e-8 Obesity-related traits; LUSC cis rs8072100 0.967 rs4794058 chr17:45597098 C/T cg08085267 chr17:45401833 C17orf57 0.54 8.78 0.43 8.52e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9393692 0.645 rs766406 chr6:26319588 G/T cg00631329 chr6:26305371 NA -0.58 -11.36 -0.53 1.63e-25 Educational attainment; LUSC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg14668632 chr7:2872130 GNA12 -0.4 -5.98 -0.31 5.77e-9 Height; LUSC cis rs4950928 0.823 rs946262 chr1:203158229 C/T cg17014757 chr1:203156097 CHI3L1 0.41 7.01 0.36 1.31e-11 YKL-40 levels; LUSC cis rs7100689 0.599 rs6585968 chr10:82139807 T/C cg01528321 chr10:82214614 TSPAN14 0.87 13.41 0.59 4.32e-33 Post bronchodilator FEV1; LUSC cis rs2760061 0.599 rs644794 chr1:228148670 T/C cg18477163 chr1:228402036 OBSCN -0.55 -10.27 -0.49 1.12e-21 Diastolic blood pressure; LUSC cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg03647239 chr10:116582469 FAM160B1 0.46 7.32 0.37 1.9e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12477438 0.765 rs7605218 chr2:99593080 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.51e-15 Chronic sinus infection; LUSC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg02221750 chr19:17393354 ANKLE1 -0.91 -14.25 -0.61 2.46e-36 Systemic lupus erythematosus; LUSC cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg07148914 chr20:33460835 GGT7 -0.52 -7.94 -0.4 3.09e-14 Glomerular filtration rate (creatinine); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14514174 chr9:99181512 ZNF367 0.41 6.16 0.32 2.14e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6009527 0.762 rs2318940 chr22:49573394 G/A cg12746016 chr22:49560550 NA 0.44 6.95 0.36 1.91e-11 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg19077165 chr18:44547161 KATNAL2 -0.41 -5.89 -0.31 9.19e-9 Personality dimensions; LUSC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC cis rs6062509 0.931 rs4809329 chr20:62348460 C/T cg01176363 chr20:62369445 LIME1 -0.47 -7.01 -0.36 1.29e-11 Prostate cancer; LUSC cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg11266682 chr4:10021025 SLC2A9 0.57 10.64 0.5 5.82e-23 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18436758 chr1:21113190 HP1BP3 -0.45 -6.12 -0.32 2.62e-9 Bipolar disorder and schizophrenia; LUSC trans rs853679 0.546 rs35744819 chr6:28318331 G/T cg01620082 chr3:125678407 NA -0.85 -7.37 -0.37 1.31e-12 Depression; LUSC cis rs7586879 0.828 rs1968482 chr2:25086858 T/C cg01884057 chr2:25150051 NA 0.4 8.18 0.41 5.86e-15 Body mass index; LUSC cis rs7795096 0.806 rs10277544 chr7:151540633 T/C cg17008978 chr7:151542804 PRKAG2 0.35 6.65 0.34 1.19e-10 Bipolar disorder (age of onset and psychotic symptoms); LUSC cis rs6121246 0.559 rs6060716 chr20:30274847 C/G cg13852791 chr20:30311386 BCL2L1 0.94 14.79 0.63 1.95e-38 Mean corpuscular hemoglobin; LUSC cis rs394563 0.622 rs237024 chr6:149721965 T/C cg11245181 chr6:149772854 ZC3H12D -0.29 -6.35 -0.33 6.84e-10 Dupuytren's disease; LUSC cis rs921968 0.565 rs755112 chr2:219606052 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.1 -0.48 4.29e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs7681440 0.904 rs28777703 chr4:90769924 A/G cg15133208 chr4:90757351 SNCA 0.32 5.68 0.3 2.95e-8 Dementia with Lewy bodies; LUSC cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg12011299 chr4:100065546 ADH4 -0.7 -10.7 -0.51 3.54e-23 Alcohol dependence; LUSC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 6.05 0.31 3.98e-9 Mean platelet volume; LUSC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.4 -0.33 5.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs656319 0.513 rs17746227 chr8:9981654 T/C cg27411982 chr8:10470053 RP1L1 -0.39 -5.81 -0.3 1.49e-8 Myopia (pathological); LUSC cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg19875535 chr5:140030758 IK -0.53 -8.78 -0.43 8.59e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg06740227 chr12:86229804 RASSF9 0.38 6.06 0.31 3.64e-9 Major depressive disorder; LUSC cis rs8141529 0.702 rs469992 chr22:29314899 T/C cg02153584 chr22:29168773 CCDC117 -0.56 -8.25 -0.41 3.67e-15 Lymphocyte counts; LUSC cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg06484146 chr7:12443880 VWDE -0.74 -7.32 -0.37 1.86e-12 Coronary artery disease; LUSC trans rs9929218 0.953 rs12920562 chr16:68737512 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -12.14 -0.55 2.47e-28 Colorectal cancer; LUSC trans rs877282 0.945 rs12776447 chr10:790625 A/G cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs1568889 0.838 rs7121937 chr11:28359858 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.87 0.58 4.52e-31 Bipolar disorder; LUSC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg07701084 chr6:150067640 NUP43 0.57 8.96 0.44 2.36e-17 Lung cancer; LUSC trans rs2797160 1.000 rs1739347 chr6:126014157 C/T cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.62e-11 Endometrial cancer; LUSC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg18230493 chr5:56204884 C5orf35 -0.69 -10.56 -0.5 1.13e-22 Coronary artery disease; LUSC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg06238570 chr21:40685208 BRWD1 0.48 7.54 0.38 4.41e-13 Cognitive function; LUSC cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg17211192 chr8:82754475 SNX16 0.76 10.09 0.48 4.45e-21 Diastolic blood pressure; LUSC cis rs7726839 0.540 rs7434 chr5:660804 A/G cg16624210 chr5:671434 TPPP -0.48 -6.36 -0.33 6.6e-10 Obesity-related traits; LUSC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg17330251 chr7:94953956 PON1 -0.36 -5.84 -0.3 1.22e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs765787 0.530 rs2668751 chr15:45517293 T/C cg25801113 chr15:45476975 SHF 0.36 7.35 0.37 1.52e-12 Uric acid levels; LUSC cis rs1865721 1.000 rs62089508 chr18:73193344 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -8.1 -0.41 1.04e-14 Intelligence; LUSC cis rs7177699 0.557 rs9806363 chr15:79110302 A/G cg00540400 chr15:79124168 NA -0.48 -8.43 -0.42 1.04e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg15017067 chr4:17643749 FAM184B 0.34 5.66 0.3 3.25e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg13390004 chr1:15929781 NA 0.39 6.75 0.35 6.49e-11 Systolic blood pressure; LUSC cis rs2629540 0.737 rs10901821 chr10:126480556 T/C cg08799069 chr10:126477246 METTL10 -0.57 -8.68 -0.43 1.78e-16 Cocaine dependence; LUSC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.12 -0.32 2.63e-9 Developmental language disorder (linguistic errors); LUSC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 6.29 0.33 9.72e-10 Electroencephalogram traits; LUSC cis rs6840360 0.571 rs7678080 chr4:152557350 A/G cg22705602 chr4:152727874 NA -0.31 -6.16 -0.32 2.13e-9 Intelligence (multi-trait analysis); LUSC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC cis rs6700896 0.522 rs12030543 chr1:66155027 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.51 5.95 0.31 6.67e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7180079 1.000 rs2306974 chr15:64486527 A/G cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs17818399 0.547 rs7607308 chr2:46759104 T/C cg02822958 chr2:46747628 ATP6V1E2 0.41 6.05 0.31 3.88e-9 Height; LUSC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg12927641 chr6:109611667 NA -0.35 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg20908204 chr19:46285434 DMPK -0.45 -8.4 -0.42 1.26e-15 Coronary artery disease; LUSC cis rs17255340 0.539 rs6908259 chr6:84050283 C/G cg08257003 chr6:84140564 ME1 0.34 8.26 0.41 3.45e-15 Platelet-derived growth factor BB levels; LUSC cis rs8077889 0.719 rs57227660 chr17:41858984 T/C cg26893861 chr17:41843967 DUSP3 1.11 22.93 0.78 1.43e-70 Triglycerides; LUSC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg21984481 chr17:79567631 NPLOC4 -0.68 -13.95 -0.61 3.49e-35 Eye color traits; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.12e-9 Menopause (age at onset); LUSC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg07636037 chr3:49044803 WDR6 0.47 6.65 0.34 1.17e-10 Resting heart rate; LUSC cis rs12760731 0.720 rs6702625 chr1:178339206 G/A cg00404053 chr1:178313656 RASAL2 0.58 6.46 0.33 3.79e-10 Obesity-related traits; LUSC cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.2e-18 Monocyte percentage of white cells; LUSC cis rs11098499 0.955 rs35434465 chr4:120169378 C/G cg09307838 chr4:120376055 NA 0.72 10.46 0.5 2.45e-22 Corneal astigmatism; LUSC cis rs6669008 1.000 rs1891969 chr1:114185855 C/A cg26035817 chr1:114414802 PTPN22 0.43 6.54 0.34 2.29e-10 Bacteremia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04296578 chr1:45671659 ZSWIM5 0.33 5.95 0.31 6.91e-9 Asthma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05210131 chr2:182757482 SSFA2 -0.44 -6.52 -0.34 2.54e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.76 0.35 6.32e-11 Intelligence (multi-trait analysis); LUSC cis rs61869271 0.805 rs769119 chr10:116778675 A/G cg23260525 chr10:116636907 FAM160B1 0.33 6.4 0.33 5.32e-10 Tonsillectomy; LUSC cis rs1832871 0.672 rs11751081 chr6:158761505 G/A cg07165851 chr6:158734300 TULP4 0.46 6.95 0.36 1.94e-11 Height; LUSC trans rs13189969 0.967 rs10071546 chr5:105285578 C/T cg17534029 chr20:62318426 RTEL1 0.32 5.99 0.31 5.37e-9 Obesity-related traits; LUSC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg09877947 chr5:131593287 PDLIM4 -0.39 -6.45 -0.33 3.99e-10 Blood metabolite levels; LUSC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg00750074 chr16:89608354 SPG7 -0.57 -10.34 -0.49 6.46e-22 Multiple myeloma (IgH translocation); LUSC cis rs7666738 0.546 rs10440329 chr4:98903735 C/T cg05340658 chr4:99064831 C4orf37 0.59 9.09 0.45 8.8e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs11971779 0.584 rs6962029 chr7:139034719 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.2 0.32 1.66e-9 Diisocyanate-induced asthma; LUSC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg10523679 chr1:76189770 ACADM 0.84 11.24 0.52 4.62e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg20476274 chr7:133979776 SLC35B4 0.85 15.4 0.64 8.52e-41 Mean platelet volume; LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg02353165 chr6:42928485 GNMT -0.65 -11.52 -0.53 4.51e-26 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg08975724 chr8:8085496 FLJ10661 -0.53 -8.23 -0.41 4.35e-15 Mood instability; LUSC cis rs8060686 0.641 rs12445396 chr16:68155121 G/A cg05110241 chr16:68378359 PRMT7 -0.56 -6.27 -0.32 1.13e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6964587 0.935 rs28412174 chr7:91577245 T/G cg01689657 chr7:91764605 CYP51A1 -0.34 -6.2 -0.32 1.68e-9 Breast cancer; LUSC cis rs16949788 1.000 rs76847935 chr15:66769613 G/A cg08120210 chr15:66682733 MAP2K1 -0.63 -6.52 -0.34 2.56e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs240764 0.578 rs1414734 chr6:101201823 T/C cg09795085 chr6:101329169 ASCC3 0.43 6.13 0.32 2.47e-9 Neuroticism; LUSC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg08859206 chr1:53392774 SCP2 -0.4 -6.49 -0.33 3.06e-10 Monocyte count; LUSC cis rs7592578 0.581 rs59109438 chr2:191287683 A/G cg10560079 chr2:191398806 TMEM194B -0.63 -8.04 -0.4 1.55e-14 Diastolic blood pressure; LUSC cis rs4363385 0.597 rs55667413 chr1:152976849 G/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.7 -0.3 2.69e-8 Inflammatory skin disease; LUSC cis rs925550 0.526 rs62322204 chr4:123629089 C/T cg10495464 chr4:123653540 BBS12;LOC729338 -0.51 -6.67 -0.34 1.08e-10 Primary biliary cholangitis; LUSC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg11245181 chr6:149772854 ZC3H12D -0.29 -6.38 -0.33 5.85e-10 Dupuytren's disease; LUSC cis rs7312933 0.524 rs11181465 chr12:42765098 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.95 0.36 1.93e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg16606324 chr3:10149918 C3orf24 -0.62 -9.31 -0.45 1.82e-18 Alzheimer's disease; LUSC trans rs61931739 0.513 rs10772116 chr12:33897795 G/C cg26384229 chr12:38710491 ALG10B 0.59 9.42 0.46 7.54e-19 Morning vs. evening chronotype; LUSC cis rs1322512 1.000 rs2758779 chr6:153008022 T/A cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg25039879 chr17:56429692 SUPT4H1 0.72 9.75 0.47 6.09e-20 Cognitive test performance; LUSC trans rs877282 0.898 rs11253339 chr10:759640 C/T cg13042288 chr15:90349979 ANPEP -0.44 -6.38 -0.33 6.08e-10 Uric acid levels; LUSC cis rs3087591 0.708 rs35109242 chr17:29649223 A/G cg24425628 chr17:29625626 OMG;NF1 0.46 6.87 0.35 3.09e-11 Hip circumference; LUSC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg20821713 chr7:1055600 C7orf50 -0.57 -7.38 -0.37 1.29e-12 Bronchopulmonary dysplasia; LUSC cis rs11122272 0.735 rs2486741 chr1:231516450 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC trans rs6951245 0.872 rs113119264 chr7:1080564 G/A cg13565492 chr6:43139072 SRF -0.56 -6.01 -0.31 4.81e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg00701064 chr4:6280414 WFS1 0.59 14.45 0.62 4.21e-37 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26748024 chr6:42420298 TRERF1 0.51 8.09 0.4 1.09e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6681460 0.932 rs523132 chr1:67174440 A/G cg02459107 chr1:67143332 SGIP1 -0.47 -8.83 -0.44 5.96e-17 Presence of antiphospholipid antibodies; LUSC cis rs193541 0.555 rs2438151 chr5:122199197 A/G cg19077854 chr5:122220652 SNX24 0.37 7.87 0.4 4.89e-14 Glucose homeostasis traits; LUSC cis rs11098499 0.866 rs7677068 chr4:120291704 C/T cg09307838 chr4:120376055 NA 0.69 10.35 0.49 5.71e-22 Corneal astigmatism; LUSC cis rs12681287 0.640 rs7841690 chr8:87365359 T/C cg00550725 chr8:87521180 FAM82B -0.42 -5.66 -0.3 3.3e-8 Caudate activity during reward; LUSC cis rs6500395 0.928 rs4553627 chr16:48708801 A/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.74 -0.35 6.78e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2559856 0.935 rs2695287 chr12:102088361 T/C cg12924262 chr12:102091054 CHPT1 0.43 6.12 0.32 2.57e-9 Blood protein levels; LUSC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg21724239 chr8:58056113 NA 0.74 8.15 0.41 7.47e-15 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg00945038 chr17:61921165 SMARCD2 0.54 9.47 0.46 5.13e-19 Prudent dietary pattern; LUSC cis rs908922 0.651 rs4845444 chr1:152530125 G/A cg20991723 chr1:152506922 NA 0.51 9.6 0.47 1.93e-19 Hair morphology; LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg08280861 chr8:58055591 NA 0.55 6.63 0.34 1.38e-10 Developmental language disorder (linguistic errors); LUSC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.83 -0.3 1.33e-8 Platelet count; LUSC trans rs12080794 1.000 rs56234523 chr1:9156034 T/C cg11315153 chr6:62996299 KHDRBS2 -0.52 -6.16 -0.32 2.13e-9 Response to antidepressant treatment (citalopram); LUSC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.82 -0.3 1.42e-8 Depression; LUSC cis rs611744 0.647 rs674391 chr8:109242803 A/T cg18478394 chr8:109455254 TTC35 0.4 6.21 0.32 1.55e-9 Dupuytren's disease; LUSC cis rs9653442 0.564 rs7593261 chr2:100789907 A/G cg22139774 chr2:100720529 AFF3 -0.38 -6.46 -0.33 3.69e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg01657329 chr11:68192670 LRP5 0.42 6.26 0.32 1.16e-9 Total body bone mineral density; LUSC cis rs79976124 0.797 rs77895756 chr6:66626782 C/T cg07460842 chr6:66804631 NA 0.7 8.63 0.43 2.62e-16 Type 2 diabetes; LUSC trans rs459571 1.000 rs459571 chr9:136912626 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.74 -12.34 -0.56 4.4e-29 Platelet distribution width; LUSC cis rs10911232 0.507 rs4652767 chr1:183002483 G/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.67e-24 Hypertriglyceridemia; LUSC cis rs17125944 0.505 rs75661138 chr14:53259262 G/A cg13660082 chr14:53194042 PSMC6 -0.78 -6.43 -0.33 4.36e-10 Alzheimer's disease (late onset); LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs921968 0.541 rs17572485 chr2:219296545 C/T cg02176678 chr2:219576539 TTLL4 -0.71 -13.66 -0.6 4.59e-34 Mean corpuscular hemoglobin concentration; LUSC cis rs1044826 0.642 rs7652860 chr3:139205818 T/A cg15131784 chr3:139108705 COPB2 0.4 6.38 0.33 5.94e-10 Obesity-related traits; LUSC cis rs6752107 1.000 rs12994971 chr2:234178453 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.73 12.26 0.56 8.75e-29 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg04352962 chr1:209979756 IRF6 0.48 6.29 0.33 1e-9 Cleft lip with or without cleft palate; LUSC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg02187348 chr16:89574699 SPG7 0.59 9.72 0.47 8.1e-20 Multiple myeloma (IgH translocation); LUSC cis rs6930083 0.713 rs1321309 chr6:36638636 G/A cg08179530 chr6:36648295 CDKN1A -0.55 -7.95 -0.4 2.95e-14 Coronary artery disease; LUSC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs7289126 1.000 rs7290372 chr22:38628388 T/G cg25457927 chr22:38595422 NA -0.29 -5.78 -0.3 1.71e-8 Mammographic density (dense area);Percent mammographic density; LUSC trans rs2790216 0.526 rs1199093 chr10:59896794 C/G cg08644993 chr1:153508755 S100A6 -0.37 -6.1 -0.32 2.96e-9 Inflammatory bowel disease; LUSC cis rs16976116 0.901 rs113679855 chr15:55502428 C/T cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7927592 0.913 rs7106010 chr11:68365212 C/T cg20283391 chr11:68216788 NA -0.61 -8.43 -0.42 1.02e-15 Total body bone mineral density; LUSC cis rs208520 0.690 rs1580430 chr6:66715162 T/A cg07460842 chr6:66804631 NA 1.09 17.24 0.69 4.32e-48 Exhaled nitric oxide output; LUSC cis rs909674 0.818 rs8136980 chr22:39844574 G/A cg05872129 chr22:39784769 NA -0.58 -9.89 -0.48 2.22e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6942756 1.000 rs6980385 chr7:128943615 G/A cg02491457 chr7:128862824 NA -0.48 -6.69 -0.34 9.62e-11 White matter hyperintensity burden; LUSC trans rs2243480 1.000 rs35421653 chr7:65363429 C/A cg10756647 chr7:56101905 PSPH 0.88 8.45 0.42 8.8e-16 Diabetic kidney disease; LUSC cis rs6460942 0.591 rs6942432 chr7:12338393 A/G cg06484146 chr7:12443880 VWDE -0.59 -6.29 -0.33 9.69e-10 Coronary artery disease; LUSC cis rs7264396 0.673 rs2425163 chr20:34432670 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.97 -0.44 2.24e-17 Total cholesterol levels; LUSC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg08999081 chr20:33150536 PIGU 0.4 7.43 0.38 8.92e-13 Height; LUSC cis rs1044826 1.000 rs13089052 chr3:139227472 C/T cg00490450 chr3:139108681 COPB2 0.51 6.8 0.35 4.8e-11 Obesity-related traits; LUSC cis rs12545109 0.917 rs1370304 chr8:57322822 G/C cg09654669 chr8:57350985 NA -0.62 -8.4 -0.42 1.3e-15 Obesity-related traits; LUSC cis rs513349 0.964 rs210139 chr6:33543409 A/C cg24505687 chr6:33548425 BAK1 0.36 5.99 0.31 5.46e-9 Platelet count; LUSC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg24250549 chr1:154909240 PMVK 0.64 10.36 0.49 5.26e-22 Prostate cancer; LUSC trans rs17685 0.796 rs3757594 chr7:75678644 G/A cg19862616 chr7:65841803 NCRNA00174 -1.13 -20.08 -0.74 2.19e-59 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg16584290 chr5:462447 EXOC3 0.44 7.95 0.4 2.99e-14 Cystic fibrosis severity; LUSC cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs868036 0.958 rs12593813 chr15:68036852 C/T cg08079166 chr15:68083412 MAP2K5 0.4 8.21 0.41 5.02e-15 Restless legs syndrome; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26720427 chr11:85780129 PICALM -0.39 -6.0 -0.31 5.12e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg14298792 chr15:30685198 CHRFAM7A -0.69 -8.93 -0.44 2.94e-17 Huntington's disease progression; LUSC cis rs2014572 0.967 rs8106734 chr19:57763546 C/T cg24459738 chr19:57751996 ZNF805 -0.52 -7.85 -0.39 5.72e-14 Hyperactive-impulsive symptoms; LUSC cis rs6740322 0.895 rs9309098 chr2:43554972 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.56 7.62 0.38 2.71e-13 Coronary artery disease; LUSC cis rs727505 0.909 rs1031958 chr7:124627309 C/T cg23710748 chr7:124431027 NA -0.36 -6.25 -0.32 1.28e-9 Lewy body disease; LUSC cis rs11637445 0.677 rs11631864 chr15:68067762 T/C cg08079166 chr15:68083412 MAP2K5 -0.37 -7.65 -0.39 2.17e-13 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg06758649 chr12:107381105 MTERFD3 -0.44 -5.97 -0.31 6.11e-9 Neuroticism; LUSC trans rs7567288 0.636 rs4256007 chr2:134464434 G/A cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg24991452 chr6:35996059 MAPK14 0.49 6.65 0.34 1.22e-10 Cognitive function;Information processing speed; LUSC cis rs7615316 0.902 rs7428496 chr3:142320532 A/T cg16271453 chr3:142027066 XRN1 -0.36 -6.11 -0.32 2.81e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.65 0.34 1.19e-10 Age-related macular degeneration (geographic atrophy); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10127479 chr1:147624510 NA 0.45 6.17 0.32 1.93e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1691799 0.899 rs903589 chr12:66745835 C/T cg16791601 chr12:66731901 HELB -0.74 -12.51 -0.56 9.93e-30 White blood cell count (basophil); LUSC cis rs9303542 0.571 rs2202895 chr17:46584657 T/C cg09704116 chr17:46666958 LOC404266 0.31 5.95 0.31 6.69e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs2439831 0.681 rs524527 chr15:43599116 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.89 -10.61 -0.5 7.27e-23 Lung cancer in ever smokers; LUSC cis rs17125944 0.686 rs8003683 chr14:53366605 G/T cg00686598 chr14:53173677 PSMC6 0.65 6.19 0.32 1.77e-9 Alzheimer's disease (late onset); LUSC cis rs243505 0.898 rs243540 chr7:148403312 A/G cg09806900 chr7:148480153 CUL1 -0.44 -6.37 -0.33 6.13e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2692947 0.702 rs2312955 chr2:96777168 T/G cg23100626 chr2:96804247 ASTL -0.31 -7.28 -0.37 2.44e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg26647111 chr11:31128758 NA -0.41 -6.0 -0.31 5.27e-9 Red blood cell count; LUSC cis rs9937943 0.615 rs12925346 chr16:74492495 G/C cg01733217 chr16:74700730 RFWD3 0.57 6.45 0.33 3.92e-10 Neutrophil percentage of white cells; LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg25072359 chr17:41440525 NA 0.65 9.38 0.46 1.06e-18 Menopause (age at onset); LUSC cis rs4604732 0.631 rs75320597 chr1:247626751 T/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg16405210 chr4:1374714 KIAA1530 -0.48 -7.07 -0.36 8.94e-12 Obesity-related traits; LUSC cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg20302533 chr7:39170763 POU6F2 0.51 8.01 0.4 1.98e-14 IgG glycosylation; LUSC trans rs2055729 0.645 rs12543996 chr8:9742666 C/T cg15556689 chr8:8085844 FLJ10661 -0.47 -5.97 -0.31 6.2e-9 Multiple myeloma (hyperdiploidy); LUSC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC cis rs3806843 0.933 rs10069930 chr5:140163328 T/A cg19875535 chr5:140030758 IK 0.49 7.89 0.4 4.41e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg16414030 chr3:133502952 NA -0.52 -8.11 -0.41 9.72e-15 Iron status biomarkers; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg06877462 chr1:205807181 PM20D1 0.49 8.82 0.43 6.26e-17 Menarche (age at onset); LUSC cis rs2050392 0.517 rs160017 chr10:30772894 A/G cg18806716 chr10:30721971 MAP3K8 -0.58 -8.91 -0.44 3.45e-17 Inflammatory bowel disease; LUSC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg11266682 chr4:10021025 SLC2A9 0.58 10.61 0.5 7.61e-23 Bone mineral density; LUSC cis rs6963495 0.818 rs6943132 chr7:105166776 C/T cg19920283 chr7:105172520 RINT1 0.59 5.85 0.3 1.16e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9359856 0.529 rs72919916 chr6:90489773 G/A cg13799429 chr6:90582589 CASP8AP2 -0.84 -8.36 -0.42 1.74e-15 Bipolar disorder; LUSC cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg19628046 chr18:33552617 C18orf21 0.53 6.74 0.35 6.93e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs4654899 0.833 rs12135548 chr1:21084367 G/A cg01072550 chr1:21505969 NA -0.47 -7.06 -0.36 9.91e-12 Superior frontal gyrus grey matter volume; LUSC cis rs8114671 0.836 rs6142294 chr20:33671497 A/G cg07148914 chr20:33460835 GGT7 -0.46 -6.81 -0.35 4.43e-11 Height; LUSC cis rs9486719 0.947 rs12194971 chr6:96911073 T/C cg06623918 chr6:96969491 KIAA0776 -0.83 -10.02 -0.48 7.57e-21 Migraine;Coronary artery disease; LUSC cis rs7582720 1.000 rs76461893 chr2:203865515 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 8.37 0.42 1.63e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs644799 0.672 rs61902245 chr11:95517737 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.6 0.6 8.13e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6756513 0.520 rs6546560 chr2:70173690 A/G cg02498382 chr2:70120550 SNRNP27 -0.26 -6.45 -0.33 3.89e-10 Breast cancer;Platelet count; LUSC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg18479299 chr3:125709523 NA -0.5 -5.79 -0.3 1.66e-8 Blood pressure (smoking interaction); LUSC cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -8.84 -0.44 5.48e-17 Chronic sinus infection; LUSC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg08280861 chr8:58055591 NA 0.54 5.89 0.31 9.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.6 0.5 8.19e-23 Bone mineral density; LUSC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg20503657 chr10:835505 NA 1.22 16.41 0.67 8.56e-45 Eosinophil percentage of granulocytes; LUSC cis rs4474465 0.790 rs4945292 chr11:78254424 T/A cg27205649 chr11:78285834 NARS2 0.53 6.46 0.33 3.72e-10 Alzheimer's disease (survival time); LUSC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg06634786 chr22:41940651 POLR3H -0.49 -6.15 -0.32 2.16e-9 Vitiligo; LUSC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC trans rs58873874 0.737 rs76634949 chr5:156890399 C/T cg18122419 chr1:50882446 NA -0.68 -5.98 -0.31 5.68e-9 Bipolar disorder (body mass index interaction); LUSC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg14440974 chr22:39074834 NA -0.37 -6.12 -0.32 2.66e-9 Menopause (age at onset); LUSC cis rs5770917 1.000 rs17848459 chr22:51012311 G/T cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.65 -5.7 -0.3 2.7e-8 Narcolepsy; LUSC cis rs11958404 0.932 rs72816579 chr5:157431877 T/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs965469 1.000 rs6037562 chr20:3326141 A/C cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.3 3.48e-8 IFN-related cytopenia; LUSC cis rs7617480 0.648 rs4858830 chr3:48734002 T/C cg07636037 chr3:49044803 WDR6 0.76 9.85 0.47 2.94e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs614226 1.000 rs1167725 chr12:120968559 A/T cg27489772 chr12:121021490 NA 0.58 7.66 0.39 1.99e-13 Type 1 diabetes nephropathy; LUSC cis rs79349575 0.783 rs12601858 chr17:47017477 T/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs10493773 0.649 rs17398321 chr1:86084493 A/G cg17807903 chr1:86174739 ZNHIT6 -0.38 -7.73 -0.39 1.31e-13 Urate levels in overweight individuals; LUSC cis rs12618769 0.597 rs10514774 chr2:99028695 A/G cg10123293 chr2:99228465 UNC50 0.47 7.9 0.4 4.19e-14 Bipolar disorder; LUSC cis rs155346 1.000 rs265145 chr5:139397332 A/G cg01090482 chr5:139365336 NRG2 0.33 5.78 0.3 1.74e-8 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs709400 0.663 rs62007683 chr14:103894071 G/T cg24130564 chr14:104152367 KLC1 -0.46 -6.36 -0.33 6.47e-10 Body mass index; LUSC cis rs7927592 0.913 rs12285993 chr11:68302538 A/G cg20283391 chr11:68216788 NA -0.61 -8.57 -0.42 3.81e-16 Total body bone mineral density; LUSC cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg06671706 chr8:8559999 CLDN23 0.49 6.52 0.34 2.66e-10 Obesity-related traits; LUSC cis rs1003719 0.715 rs762139 chr21:38568475 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.61 9.0 0.44 1.72e-17 Eye color traits; LUSC cis rs4253772 0.720 rs4253778 chr22:46630634 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.45 6.27 0.32 1.1e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs4654899 0.772 rs61778530 chr1:21087363 G/C cg01072550 chr1:21505969 NA -0.48 -7.11 -0.36 6.95e-12 Superior frontal gyrus grey matter volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24430517 chr2:242673979 D2HGDH 0.44 6.29 0.33 1.01e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg05347473 chr6:146136440 FBXO30 0.47 7.77 0.39 9.97e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg14552801 chr7:65878734 NA 0.38 5.9 0.31 8.97e-9 Aortic root size; LUSC cis rs8072100 0.967 rs4794001 chr17:45720849 T/C cg08085267 chr17:45401833 C17orf57 -0.55 -8.99 -0.44 1.86e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2242194 0.816 rs11264296 chr1:154994750 T/C cg16680214 chr1:154839983 KCNN3 -0.35 -6.26 -0.32 1.18e-9 Schizophrenia; LUSC cis rs4629180 0.630 rs10188189 chr2:102127926 A/G cg01388757 chr2:102091195 RFX8 -0.36 -6.23 -0.32 1.4e-9 Chronic rhinosinusitis with nasal polyps; LUSC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg03929089 chr4:120376271 NA -0.77 -12.22 -0.56 1.19e-28 Height; LUSC cis rs16917546 1.000 rs10995251 chr10:64398466 C/T cg03961010 chr10:64397487 ZNF365 -0.42 -6.58 -0.34 1.81e-10 Basal cell carcinoma; LUSC cis rs17401966 0.540 rs1536262 chr1:10438687 C/T cg17425144 chr1:10567563 PEX14 -0.35 -6.26 -0.32 1.18e-9 Hepatocellular carcinoma; LUSC cis rs1003719 0.680 rs2835619 chr21:38505380 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg00684032 chr4:1343700 KIAA1530 0.34 5.8 0.3 1.58e-8 Obesity-related traits; LUSC cis rs16854884 0.770 rs6784938 chr3:143817528 C/T cg06585982 chr3:143692056 C3orf58 0.4 5.94 0.31 7.13e-9 Economic and political preferences (feminism/equality); LUSC cis rs9987353 0.544 rs2929470 chr8:9062490 A/G cg15556689 chr8:8085844 FLJ10661 -0.41 -5.92 -0.31 7.95e-9 Recombination measurement; LUSC cis rs4974559 1.000 rs10006789 chr4:1330333 T/C cg02980000 chr4:1222292 CTBP1 0.68 7.94 0.4 3.14e-14 Systolic blood pressure; LUSC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg20243544 chr17:37824526 PNMT 0.52 7.43 0.38 9.33e-13 Asthma; LUSC cis rs11098499 0.775 rs10029303 chr4:120286755 T/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs7945718 0.810 rs7930282 chr11:12835941 C/T cg25843174 chr11:12811716 TEAD1 0.3 6.87 0.35 3.23e-11 Educational attainment (years of education); LUSC cis rs709400 0.663 rs62007718 chr14:103940436 G/A cg10523860 chr14:103875565 MARK3 -0.37 -5.94 -0.31 7.11e-9 Body mass index; LUSC cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14240646 chr10:27532245 ACBD5 -0.65 -7.75 -0.39 1.15e-13 Breast cancer; LUSC cis rs9929218 0.529 rs17715450 chr16:68729785 C/A cg01251360 chr16:68772225 CDH1 -0.27 -6.3 -0.33 9.13e-10 Colorectal cancer; LUSC trans rs62238980 0.614 rs78818509 chr22:32447582 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs314370 0.951 rs12667888 chr7:100474289 T/C cg10426581 chr7:100472382 SRRT 0.86 12.47 0.56 1.43e-29 Resting heart rate; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02737830 chr12:64616354 C12orf66 0.42 6.51 0.34 2.82e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg26958806 chr6:27640298 NA 0.63 5.65 0.3 3.39e-8 Depression; LUSC cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg18876405 chr7:65276391 NA 0.5 6.88 0.35 2.9e-11 Corneal structure; LUSC cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs7605827 0.930 rs13033762 chr2:15592295 T/C cg19274914 chr2:15703543 NA 0.46 8.66 0.43 1.98e-16 Educational attainment (years of education); LUSC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs4969178 0.965 rs938350 chr17:76399552 C/T cg05887092 chr17:76393375 PGS1 0.51 9.42 0.46 7.73e-19 HDL cholesterol levels; LUSC cis rs8017423 0.608 rs12588149 chr14:90822676 G/A cg04374321 chr14:90722782 PSMC1 -0.42 -6.34 -0.33 7.59e-10 Mortality in heart failure; LUSC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg19077165 chr18:44547161 KATNAL2 -0.37 -5.65 -0.3 3.43e-8 Personality dimensions; LUSC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs6754311 0.731 rs7569057 chr2:136583958 A/C cg25344623 chr2:136566232 LCT -0.38 -5.7 -0.3 2.7e-8 Mosquito bite size; LUSC cis rs9640161 0.659 rs7781827 chr7:150008858 T/C cg10018233 chr7:150070692 REPIN1 0.35 6.24 0.32 1.32e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg24296786 chr1:45957014 TESK2 0.48 7.36 0.37 1.45e-12 High light scatter reticulocyte count; LUSC trans rs61931739 0.500 rs1843736 chr12:34012080 C/G cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 3.03e-25 Morning vs. evening chronotype; LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg25767906 chr1:53392781 SCP2 -0.49 -8.81 -0.43 7.08e-17 Monocyte count; LUSC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg02569458 chr12:86230093 RASSF9 0.52 8.64 0.43 2.29e-16 Major depressive disorder; LUSC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.46 0.38 7.73e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2486288 0.656 rs11854365 chr15:45558083 G/A cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.6 -0.5 8.24e-23 Glomerular filtration rate; LUSC cis rs3740713 0.669 rs61736803 chr11:18422487 C/A cg07915343 chr11:18477680 LDHAL6A -0.47 -5.87 -0.31 1.03e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs61931739 0.853 rs7137146 chr12:34102394 G/A cg06521331 chr12:34319734 NA 0.37 6.34 0.33 7.6e-10 Morning vs. evening chronotype; LUSC cis rs11240408 1 rs11240408 chr1:205264536 A/T cg00857998 chr1:205179979 DSTYK -0.53 -8.02 -0.4 1.79e-14 Platelet count; LUSC cis rs240764 0.817 rs239232 chr6:101103038 G/A cg09795085 chr6:101329169 ASCC3 0.4 5.85 0.31 1.14e-8 Neuroticism; LUSC cis rs7605827 0.897 rs11901455 chr2:15623888 C/T cg19274914 chr2:15703543 NA 0.45 8.57 0.42 3.81e-16 Educational attainment (years of education); LUSC cis rs2901656 0.502 rs9425308 chr1:172383265 A/C cg03748243 chr1:172413542 C1orf105;PIGC 0.3 5.78 0.3 1.68e-8 Red cell distribution width;Platelet distribution width; LUSC cis rs921968 0.528 rs35695178 chr2:219589164 C/T cg02176678 chr2:219576539 TTLL4 -0.58 -10.3 -0.49 8.75e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg26039829 chr8:22132926 PIWIL2 0.42 7.76 0.39 1.07e-13 Hypertriglyceridemia; LUSC cis rs6456156 0.692 rs9457270 chr6:167512928 A/G cg07741184 chr6:167504864 NA 0.46 7.82 0.39 7.03e-14 Primary biliary cholangitis; LUSC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg14416269 chr4:6271139 WFS1 0.54 11.39 0.53 1.32e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs6840360 0.533 rs13121178 chr4:152729047 T/C cg22705602 chr4:152727874 NA 0.34 7.14 0.36 5.92e-12 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.644 rs17517414 chr4:120262101 G/C cg09307838 chr4:120376055 NA 0.63 9.49 0.46 4.62e-19 Corneal astigmatism; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.7 0.39 1.52e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg13072238 chr3:49761600 GMPPB -0.71 -8.92 -0.44 3.03e-17 Menarche (age at onset); LUSC cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg15839431 chr19:19639596 YJEFN3 -0.61 -6.79 -0.35 5.08e-11 Bipolar disorder; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg22696982 chr2:177502905 NA 0.39 6.53 0.34 2.51e-10 Schizophrenia; LUSC cis rs2425143 1.000 rs6060557 chr20:34270266 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -6.37 -0.33 6.32e-10 Blood protein levels; LUSC trans rs459571 0.920 rs455073 chr9:136909141 G/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.79 -13.21 -0.59 2.49e-32 Platelet distribution width; LUSC trans rs9910292 0.591 rs12602361 chr17:31362864 T/C cg03789507 chr8:136667083 NA 0.5 6.27 0.32 1.13e-9 Mosquito bite size; LUSC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg20891283 chr12:69753455 YEATS4 0.81 14.74 0.63 3.04e-38 Blood protein levels; LUSC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs6740322 0.843 rs6727237 chr2:43562000 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.41 -5.75 -0.3 1.99e-8 Coronary artery disease; LUSC cis rs11792861 0.781 rs2297581 chr9:111755008 C/T cg13535736 chr9:111863775 C9orf5 -0.39 -6.13 -0.32 2.46e-9 Menarche (age at onset); LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg24829409 chr8:58192753 C8orf71 -0.58 -6.24 -0.32 1.33e-9 Developmental language disorder (linguistic errors); LUSC cis rs7829975 0.617 rs4841072 chr8:8791253 C/A cg15556689 chr8:8085844 FLJ10661 -0.59 -9.76 -0.47 5.6e-20 Mood instability; LUSC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg15790184 chr11:494944 RNH1 0.49 7.53 0.38 4.71e-13 Systemic lupus erythematosus; LUSC cis rs8180040 0.726 rs6774733 chr3:46991241 G/A cg27129171 chr3:47204927 SETD2 0.74 12.88 0.58 4.37e-31 Colorectal cancer; LUSC cis rs2607426 1.000 rs2607419 chr19:41279395 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.72 6.3 0.33 9.42e-10 Blood protein levels; LUSC cis rs11645898 0.872 rs55955726 chr16:72213691 G/C cg14768367 chr16:72042858 DHODH -0.58 -6.37 -0.33 6.41e-10 Blood protein levels; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg00149659 chr3:10157352 C3orf10 0.96 13.92 0.61 4.8e-35 Alzheimer's disease; LUSC cis rs12155623 0.504 rs10808736 chr8:49873039 C/A cg22283653 chr8:49824208 NA 0.39 7.97 0.4 2.57e-14 Sudden cardiac arrest; LUSC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg20135002 chr11:47629003 NA -0.51 -7.97 -0.4 2.54e-14 Subjective well-being; LUSC cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg06784218 chr1:46089804 CCDC17 0.48 9.5 0.46 4.33e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7168353 0.948 rs10520720 chr15:93634724 A/G cg04697454 chr15:93633408 RGMA -0.36 -5.99 -0.31 5.43e-9 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs10876993 0.715 rs2169987 chr12:58012111 G/A cg18357645 chr12:58087776 OS9 -0.52 -7.65 -0.39 2.22e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.1 0.52 1.41e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs6701037 0.748 rs11583687 chr1:175132049 A/C cg00321850 chr1:175162397 KIAA0040 0.44 7.15 0.36 5.55e-12 Alcohol dependence; LUSC cis rs7582720 1.000 rs72936869 chr2:203788950 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4077515 0.874 rs35670379 chr9:139270606 T/C cg14019695 chr9:139328340 INPP5E 0.43 8.21 0.41 4.87e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC trans rs8073060 0.586 rs7221203 chr17:34015532 T/C cg19694781 chr19:47549865 TMEM160 -1.13 -17.91 -0.7 9.52e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg05313129 chr8:58192883 C8orf71 -0.51 -5.99 -0.31 5.57e-9 Developmental language disorder (linguistic errors); LUSC cis rs9473147 0.543 rs9296558 chr6:47451883 C/T cg20196966 chr6:47445060 CD2AP 0.43 6.05 0.31 3.8e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg22963979 chr7:1858916 MAD1L1 -0.7 -11.43 -0.53 8.94e-26 Bipolar disorder and schizophrenia; LUSC cis rs2180341 0.618 rs12210968 chr6:127596985 A/G cg24812749 chr6:127587940 RNF146 0.65 9.76 0.47 5.91e-20 Breast cancer; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg24105280 chr12:6797846 ZNF384 0.53 6.3 0.33 9.17e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg01448562 chr3:133502909 NA -0.53 -7.97 -0.4 2.62e-14 Iron status biomarkers; LUSC cis rs6681460 0.549 rs7537440 chr1:67031907 A/C cg02459107 chr1:67143332 SGIP1 0.31 5.69 0.3 2.74e-8 Presence of antiphospholipid antibodies; LUSC cis rs1048238 0.506 rs10927866 chr1:16175317 C/T cg22431228 chr1:16359049 CLCNKA -0.39 -8.25 -0.41 3.79e-15 Systolic blood pressure; LUSC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9921338 0.961 rs4781069 chr16:11428762 G/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.66 -0.34 1.14e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.79 0.43 7.9e-17 Prudent dietary pattern; LUSC cis rs4654899 0.772 rs12145203 chr1:21086127 C/T cg01072550 chr1:21505969 NA -0.44 -6.53 -0.34 2.41e-10 Superior frontal gyrus grey matter volume; LUSC cis rs41271951 0.512 rs76649628 chr1:151041851 A/G cg11822372 chr1:151115635 SEMA6C -0.76 -6.95 -0.36 1.98e-11 Blood protein levels; LUSC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.63 -9.83 -0.47 3.34e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.69 0.3 2.74e-8 Life satisfaction; LUSC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg24675658 chr1:53192096 ZYG11B 0.62 9.91 0.48 1.78e-20 Monocyte count; LUSC cis rs500891 1.000 rs35442758 chr6:84183607 G/A cg08257003 chr6:84140564 ME1 0.34 7.02 0.36 1.26e-11 Platelet-derived growth factor BB levels; LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.74 0.65 3.76e-42 Platelet count; LUSC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg26647111 chr11:31128758 NA -0.42 -5.98 -0.31 5.6e-9 Red blood cell count; LUSC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg00908189 chr16:619842 PIGQ 0.67 10.41 0.5 3.54e-22 Height; LUSC cis rs8014204 0.604 rs7156590 chr14:75388183 C/T cg06637938 chr14:75390232 RPS6KL1 0.84 15.57 0.65 1.71e-41 Caffeine consumption; LUSC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg02428538 chr16:24856791 SLC5A11 -0.52 -5.98 -0.31 5.74e-9 Intelligence (multi-trait analysis); LUSC cis rs6940638 0.662 rs7759694 chr6:27240956 C/T cg12292205 chr6:26970375 C6orf41 -0.41 -6.23 -0.32 1.41e-9 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.534 rs7133262 chr12:34279444 G/A cg13010199 chr12:38710504 ALG10B 0.53 8.26 0.41 3.43e-15 Morning vs. evening chronotype; LUSC cis rs6542838 0.641 rs6542841 chr2:99489039 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.36 -0.33 6.68e-10 Fear of minor pain; LUSC cis rs11756438 0.572 rs2798328 chr6:119005378 C/T cg18833306 chr6:118973337 C6orf204 0.36 5.69 0.3 2.8e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Vitiligo; LUSC cis rs6964587 0.839 rs10236107 chr7:91485461 G/A cg22709100 chr7:91322751 NA -0.4 -5.94 -0.31 6.99e-9 Breast cancer; LUSC cis rs929596 0.728 rs6744284 chr2:234625297 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.61 -10.3 -0.49 8.49e-22 Total bilirubin levels in HIV-1 infection; LUSC cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.74 -0.43 1.17e-16 Monocyte percentage of white cells; LUSC cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.39 5.78 0.3 1.72e-8 Schizophrenia; LUSC cis rs11039100 0.850 rs11039115 chr11:5831379 T/C cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC trans rs2700987 0.545 rs2717953 chr7:37390545 A/T cg26076750 chr5:98105150 RGMB -0.33 -6.04 -0.31 4.21e-9 Psoriasis vulgaris;Psoriasis; LUSC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg21573476 chr21:45109991 RRP1B -0.41 -6.77 -0.35 5.76e-11 Mean corpuscular volume; LUSC cis rs2404602 0.692 rs34272342 chr15:77012276 A/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.81e-12 Blood metabolite levels; LUSC cis rs9926296 0.609 rs4785714 chr16:89798404 G/T cg01097406 chr16:89675127 NA 0.32 6.37 0.33 6.28e-10 Vitiligo; LUSC trans rs17641971 1.000 rs73579360 chr8:49920586 C/T cg15678142 chr1:167411538 CD247 0.42 5.97 0.31 6.09e-9 Blood metabolite levels; LUSC cis rs66486766 1 rs66486766 chr15:84806060 G/A cg12863693 chr15:85201151 NMB 0.35 6.93 0.35 2.15e-11 Bipolar disorder lithium response (categorical) or schizophrenia; LUSC trans rs3733585 0.648 rs13125029 chr4:9982029 A/G cg26043149 chr18:55253948 FECH 0.46 7.09 0.36 8.28e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg09626299 chr10:82213104 TSPAN14 -0.2 -5.87 -0.31 1.06e-8 Post bronchodilator FEV1; LUSC cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg15423357 chr2:25149977 NA 0.45 9.15 0.45 5.98e-18 Body mass index; LUSC cis rs7493 0.950 rs11981299 chr7:95029701 T/A cg17330251 chr7:94953956 PON1 -0.36 -5.74 -0.3 2.11e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6489882 0.807 rs1859334 chr12:113367332 C/T cg20102336 chr12:113376681 OAS3 -0.42 -5.96 -0.31 6.39e-9 Chronic lymphocytic leukemia; LUSC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs765787 0.530 rs2899379 chr15:45534799 C/T cg24006582 chr15:45444508 DUOX1 0.65 9.23 0.45 3.13e-18 Uric acid levels; LUSC trans rs769111 0.812 rs2908734 chr7:12070537 A/G cg02081925 chr5:176931394 DOK3 0.38 6.17 0.32 1.96e-9 Tourette syndrome; LUSC cis rs12542260 0.871 rs7834203 chr8:125482896 A/G cg27038428 chr8:125485867 RNF139 0.33 6.71 0.34 8.12e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs4727027 0.704 rs13229244 chr7:148898219 A/C cg23158103 chr7:148848205 ZNF398 0.49 8.41 0.42 1.25e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg25072359 chr17:41440525 NA 0.66 9.44 0.46 6.54e-19 Menopause (age at onset); LUSC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg12365402 chr11:9010492 NRIP3 -0.47 -8.91 -0.44 3.27e-17 Hemoglobin concentration; LUSC cis rs11031096 0.782 rs11031110 chr11:4162652 G/C cg18678763 chr11:4115507 RRM1 -0.54 -7.64 -0.39 2.31e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs847577 0.609 rs6965016 chr7:97807882 C/A cg21770322 chr7:97807741 LMTK2 0.56 10.08 0.48 4.97e-21 Breast cancer; LUSC cis rs10744422 0.858 rs10773627 chr12:123311853 A/G cg25930673 chr12:123319894 HIP1R -0.64 -6.39 -0.33 5.68e-10 Schizophrenia; LUSC cis rs1267303 0.642 rs61783087 chr1:46999955 T/C cg25110126 chr1:46999211 NA 0.77 10.96 0.51 4.35e-24 Monobrow; LUSC cis rs10089 0.953 rs6879970 chr5:127387178 A/G cg19767477 chr5:127420684 SLC12A2 -0.4 -5.74 -0.3 2.12e-8 Ileal carcinoids; LUSC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg21028142 chr17:79581711 NPLOC4 0.34 8.2 0.41 5.32e-15 Eye color traits; LUSC cis rs10791097 0.667 rs4937585 chr11:130741940 A/G cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.5e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs12310956 0.515 rs1872745 chr12:33985987 G/A cg06521331 chr12:34319734 NA -0.47 -7.55 -0.38 4.09e-13 Morning vs. evening chronotype; LUSC cis rs10504073 0.584 rs11778863 chr8:49954893 C/T cg00325661 chr8:49890786 NA 0.7 11.14 0.52 9.84e-25 Blood metabolite ratios; LUSC trans rs2357013 0.574 rs66762357 chr2:53155017 C/G cg24904739 chr17:77959804 TBC1D16 -0.37 -6.0 -0.31 5e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.15e-14 Glomerular filtration rate (creatinine); LUSC cis rs754133 0.963 rs12319419 chr12:54420776 G/C cg10005224 chr12:54424964 HOXC4;HOXC5 0.43 8.48 0.42 7.6e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs698813 0.604 rs1596010 chr2:44491804 A/C cg00619915 chr2:44497795 NA -0.53 -7.48 -0.38 6.41e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs1865760 0.713 rs1130000 chr6:25985396 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.92 0.35 2.29e-11 Height; LUSC cis rs9467773 1.000 rs1321481 chr6:26538210 A/T cg09904177 chr6:26538194 HMGN4 0.75 14.27 0.62 2.07e-36 Intelligence (multi-trait analysis); LUSC cis rs7220401 0.515 rs8080772 chr17:28413129 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.53 -7.46 -0.38 7.69e-13 Coronary artery disease; LUSC cis rs2070433 0.559 rs11089057 chr21:47721228 T/A cg12379764 chr21:47803548 PCNT 0.73 8.46 0.42 8.55e-16 Lymphocyte counts; LUSC trans rs1493916 0.905 rs4239383 chr18:31401066 T/C cg27147174 chr7:100797783 AP1S1 -0.65 -10.53 -0.5 1.45e-22 Life satisfaction; LUSC cis rs7615952 0.546 rs4428131 chr3:125346479 C/T cg05084668 chr3:125655381 ALG1L -0.45 -6.02 -0.31 4.67e-9 Blood pressure (smoking interaction); LUSC cis rs72792276 1.000 rs72794370 chr5:127444907 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.92 7.84 0.39 5.98e-14 Red cell distribution width; LUSC cis rs9303401 0.704 rs740605 chr17:56604811 C/T cg12560992 chr17:57184187 TRIM37 0.53 7.81 0.39 7.29e-14 Cognitive test performance; LUSC cis rs2625529 0.530 rs2959930 chr15:72598614 A/G cg16672083 chr15:72433130 SENP8 -0.43 -6.63 -0.34 1.35e-10 Red blood cell count; LUSC trans rs1994135 0.594 rs10772096 chr12:33732869 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.01 0.36 1.32e-11 Resting heart rate; LUSC cis rs3770081 1.000 rs2241437 chr2:86360573 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.01 -6.72 -0.34 8.1e-11 Facial emotion recognition (sad faces); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04531794 chr10:99609860 GOLGA7B -0.5 -6.51 -0.34 2.75e-10 Bipolar disorder and schizophrenia; LUSC cis rs617219 0.853 rs55868416 chr5:78463527 C/T cg24856658 chr5:78533917 JMY -0.29 -5.67 -0.3 3.1e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs6977660 0.941 rs5017192 chr7:19820114 C/T cg07541023 chr7:19748670 TWISTNB 0.5 5.69 0.3 2.79e-8 Thyroid stimulating hormone; LUSC cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.17 0.55 1.93e-28 Motion sickness; LUSC cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg23711669 chr6:146136114 FBXO30 0.86 15.52 0.65 2.69e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg19318889 chr4:1322082 MAEA 0.49 8.06 0.4 1.4e-14 Obesity-related traits; LUSC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -0.95 -14.92 -0.63 6.45e-39 Platelet count; LUSC trans rs8072100 1.000 rs7210738 chr17:45757598 G/A cg03886242 chr7:26192032 NFE2L3 0.38 6.29 0.33 9.81e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs34375054 0.641 rs34624329 chr12:125608028 T/G cg00522288 chr12:125625016 AACS -0.29 -5.68 -0.3 2.89e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs8017423 0.935 rs9944124 chr14:90791501 T/C cg04374321 chr14:90722782 PSMC1 0.67 10.43 0.5 3.13e-22 Mortality in heart failure; LUSC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg20406979 chr6:167373233 NA 0.25 5.96 0.31 6.39e-9 Crohn's disease; LUSC cis rs9309473 0.660 rs10496192 chr2:73679866 T/C cg20560298 chr2:73613845 ALMS1 -0.55 -6.56 -0.34 2.07e-10 Metabolite levels; LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg10360139 chr7:1886902 MAD1L1 -0.46 -7.08 -0.36 8.61e-12 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.954 rs28429722 chr4:120300093 G/A cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs9467711 0.720 rs75782365 chr6:26408551 T/G cg09904177 chr6:26538194 HMGN4 -0.76 -5.64 -0.3 3.57e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg12310025 chr6:25882481 NA 0.47 7.89 0.4 4.49e-14 Intelligence (multi-trait analysis); LUSC cis rs11048434 0.761 rs12824380 chr12:9132017 A/G cg23795048 chr12:9217529 LOC144571 0.33 5.7 0.3 2.67e-8 Sjögren's syndrome; LUSC trans rs34421088 0.560 rs2248325 chr8:11396874 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.41 -0.46 8.23e-19 Neuroticism; LUSC cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg21573476 chr21:45109991 RRP1B 0.37 5.81 0.3 1.45e-8 Mean corpuscular volume; LUSC cis rs4820539 0.966 rs2267000 chr22:23455366 A/G cg21100191 chr22:23484243 RTDR1 0.89 14.98 0.63 3.54e-39 Bone mineral density; LUSC cis rs922692 0.715 rs2277546 chr15:79083376 C/A cg00540400 chr15:79124168 NA -0.41 -7.11 -0.36 7.2e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs7615952 0.609 rs13088451 chr3:125553499 G/C cg00769240 chr8:12517080 NA -0.48 -6.31 -0.33 8.66e-10 Blood pressure (smoking interaction); LUSC trans rs890100 0.801 rs10189319 chr2:56706672 C/G cg01657744 chr10:88471748 LDB3 0.44 6.09 0.32 3.05e-9 Gut microbiome composition (summer); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04631804 chr4:110624697 CASP6 -0.43 -6.18 -0.32 1.86e-9 Hepatitis; LUSC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg20406979 chr6:167373233 NA -0.26 -6.0 -0.31 5.04e-9 Lung cancer; LUSC cis rs139156536 1 rs139156536 chr17:38164432 TTTTA/T cg17344932 chr17:38183730 MED24;SNORD124 -0.61 -10.64 -0.5 5.77e-23 Lymphocyte percentage of white cells; LUSC cis rs7520050 0.751 rs2230657 chr1:46073489 G/A cg06784218 chr1:46089804 CCDC17 -0.29 -5.65 -0.3 3.48e-8 Red blood cell count;Reticulocyte count; LUSC cis rs6062509 0.732 rs6062304 chr20:62351539 A/T cg21849932 chr20:62369462 LIME1 -0.4 -5.93 -0.31 7.59e-9 Prostate cancer; LUSC cis rs2625529 0.730 rs12912771 chr15:72162928 A/T cg16672083 chr15:72433130 SENP8 -0.47 -8.11 -0.41 9.79e-15 Red blood cell count; LUSC cis rs34172651 0.917 rs6497756 chr16:24798291 G/T cg06028605 chr16:24865363 SLC5A11 0.46 8.1 0.41 1.03e-14 Intelligence (multi-trait analysis); LUSC trans rs877282 0.891 rs12767043 chr10:797943 C/T cg22713356 chr15:30763199 NA 1.11 15.86 0.66 1.27e-42 Uric acid levels; LUSC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg26513180 chr16:89883248 FANCA 0.66 10.63 0.5 6.17e-23 Vitiligo; LUSC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg26769984 chr7:1090371 C7orf50 0.59 8.26 0.41 3.43e-15 Bronchopulmonary dysplasia; LUSC cis rs877282 0.853 rs7083589 chr10:754494 G/A cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg07701084 chr6:150067640 NUP43 0.53 7.94 0.4 3.18e-14 Lung cancer; LUSC cis rs7107174 0.681 rs3102742 chr11:77949334 G/T cg02023728 chr11:77925099 USP35 0.48 6.4 0.33 5.13e-10 Testicular germ cell tumor; LUSC cis rs4680 0.712 rs740601 chr22:19950763 T/G cg23601416 chr22:19950040 COMT -0.44 -9.17 -0.45 5.16e-18 Blood metabolite levels; LUSC cis rs8017423 0.935 rs11624890 chr14:90738165 T/A cg04374321 chr14:90722782 PSMC1 -0.69 -10.44 -0.5 2.94e-22 Mortality in heart failure; LUSC cis rs4268898 0.896 rs2702042 chr2:24546542 C/T cg06627628 chr2:24431161 ITSN2 -0.63 -9.58 -0.46 2.23e-19 Asthma; LUSC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.43 0.65 6.21e-41 Intelligence (multi-trait analysis); LUSC cis rs10876993 0.890 rs1585781 chr12:58056701 T/G cg15848620 chr12:58087721 OS9 -0.55 -7.87 -0.4 4.88e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs8114671 0.836 rs13042358 chr20:33634479 G/A cg07148914 chr20:33460835 GGT7 -0.45 -6.67 -0.34 1.07e-10 Height; LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.54e-10 Menopause (age at onset); LUSC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.99 0.55 8.64e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 8.25 0.41 3.71e-15 Height; LUSC cis rs8099014 0.911 rs4331413 chr18:56133165 T/C cg12907477 chr18:56117327 MIR122 0.4 6.02 0.31 4.69e-9 Platelet count; LUSC cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg05347473 chr6:146136440 FBXO30 0.47 7.92 0.4 3.57e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7809950 1.000 rs1544336 chr7:107082415 G/C cg23024343 chr7:107201750 COG5 -0.54 -8.71 -0.43 1.38e-16 Coronary artery disease; LUSC cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg06550200 chr5:1325588 CLPTM1L -0.66 -11.35 -0.53 1.83e-25 Lung cancer; LUSC cis rs11098499 1.000 rs13435802 chr4:120177960 A/T cg24375607 chr4:120327624 NA -0.73 -11.2 -0.52 6.12e-25 Corneal astigmatism; LUSC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11644478 chr21:40555479 PSMG1 -0.82 -14.86 -0.63 1.03e-38 Cognitive function; LUSC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg15352829 chr14:105391018 PLD4 -0.39 -8.28 -0.41 3.09e-15 Rheumatoid arthritis; LUSC cis rs7927592 0.546 rs683978 chr11:68192421 T/C cg16797656 chr11:68205561 LRP5 0.45 7.8 0.39 8.18e-14 Total body bone mineral density; LUSC cis rs7503807 1.000 rs901064 chr17:78596040 C/T cg09596252 chr17:78655493 RPTOR -0.43 -7.45 -0.38 7.82e-13 Obesity; LUSC cis rs7043114 0.525 rs9299404 chr9:95170338 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.38 6.63 0.34 1.32e-10 Height; LUSC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg05707623 chr12:122985044 ZCCHC8 -0.63 -8.09 -0.4 1.09e-14 Body mass index; LUSC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg27121462 chr16:89883253 FANCA 0.57 9.25 0.45 2.66e-18 Vitiligo; LUSC cis rs981844 0.775 rs56101345 chr4:154764261 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.77 0.35 5.94e-11 Response to statins (LDL cholesterol change); LUSC cis rs7208859 0.573 rs73267865 chr17:29064204 C/G cg13385521 chr17:29058706 SUZ12P 0.71 7.04 0.36 1.12e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg16049864 chr8:95962084 TP53INP1 -0.48 -8.02 -0.4 1.82e-14 Type 2 diabetes; LUSC cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg26373071 chr5:1325741 CLPTM1L 0.41 7.69 0.39 1.72e-13 Lung cancer; LUSC cis rs7707921 0.958 rs4703870 chr5:81492643 G/A cg15871215 chr5:81402204 ATG10 0.44 6.34 0.33 7.5e-10 Breast cancer; LUSC cis rs6967385 0.560 rs12539290 chr7:12344101 T/G cg20607287 chr7:12443886 VWDE 0.44 6.59 0.34 1.71e-10 Response to taxane treatment (placlitaxel); LUSC cis rs861020 0.630 rs657861 chr1:210006884 C/G cg05527609 chr1:210001259 C1orf107 0.68 9.67 0.47 1.12e-19 Orofacial clefts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08749455 chr11:72492538 STARD10 0.44 6.24 0.32 1.35e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg19812747 chr11:111475976 SIK2 -0.55 -8.18 -0.41 5.92e-15 Primary sclerosing cholangitis; LUSC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg27121462 chr16:89883253 FANCA -0.55 -8.9 -0.44 3.55e-17 Vitiligo; LUSC cis rs4343996 0.659 rs9986894 chr7:3335346 A/C cg21248987 chr7:3385318 SDK1 0.35 6.09 0.32 3.08e-9 Motion sickness; LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg09436375 chr6:42928200 GNMT -0.29 -6.82 -0.35 4.33e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs28647808 0.748 rs28502181 chr9:136257792 T/G cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg27114661 chr2:242255285 SEPT2;HDLBP 0.42 6.11 0.32 2.82e-9 N-glycan levels; LUSC trans rs12458462 0.859 rs35493271 chr18:77448793 G/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.8 -0.35 4.93e-11 Monocyte count; LUSC cis rs10504073 0.647 rs59064792 chr8:50018337 A/C cg00325661 chr8:49890786 NA 0.62 10.39 0.49 4.27e-22 Blood metabolite ratios; LUSC cis rs12530845 0.887 rs73725434 chr7:135313657 T/C cg23117316 chr7:135346802 PL-5283 -0.58 -9.31 -0.45 1.82e-18 Red blood cell traits; LUSC cis rs929354 0.707 rs1182445 chr7:157024428 C/G cg05182265 chr7:156933206 UBE3C 0.6 9.74 0.47 6.75e-20 Body mass index; LUSC cis rs3820068 0.608 rs12091326 chr1:16048005 A/G cg17385448 chr1:15911702 AGMAT 0.36 5.87 0.31 1.05e-8 Systolic blood pressure; LUSC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg16386425 chr10:429943 DIP2C -0.44 -7.11 -0.36 7.08e-12 Psychosis in Alzheimer's disease; LUSC cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs17401966 0.522 rs2027330 chr1:10275592 C/T cg17425144 chr1:10567563 PEX14 -0.33 -5.78 -0.3 1.69e-8 Hepatocellular carcinoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04619838 chr16:67515103 ATP6V0D1 0.77 6.15 0.32 2.17e-9 Cognitive performance; LUSC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg08219700 chr8:58056026 NA 0.62 6.81 0.35 4.55e-11 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg13206674 chr6:150067644 NUP43 0.63 10.35 0.49 5.98e-22 Lung cancer; LUSC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg10253484 chr15:75165896 SCAMP2 -0.47 -6.61 -0.34 1.52e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11122272 0.766 rs2790867 chr1:231548059 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.7 11.03 0.52 2.5e-24 Hemoglobin concentration; LUSC cis rs9921338 0.961 rs7191093 chr16:11442279 A/G cg00044050 chr16:11439710 C16orf75 -0.51 -6.81 -0.35 4.58e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC trans rs10506458 0.915 rs998506 chr12:63400017 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.8 -0.65 2.22e-42 Hemostatic factors and hematological phenotypes; LUSC cis rs11048434 0.736 rs933462 chr12:9103665 T/G cg13575925 chr12:9217583 LOC144571 0.35 6.36 0.33 6.77e-10 Sjögren's syndrome; LUSC trans rs12310956 0.532 rs6488186 chr12:33974122 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.82 0.51 1.41e-23 Morning vs. evening chronotype; LUSC cis rs11098499 0.780 rs7692994 chr4:120427489 C/A cg09307838 chr4:120376055 NA 0.69 10.4 0.49 3.96e-22 Corneal astigmatism; LUSC cis rs1979679 0.608 rs4931084 chr12:28722311 C/G cg13890972 chr12:28721907 NA -0.43 -6.11 -0.32 2.79e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg20203395 chr5:56204925 C5orf35 -0.46 -6.72 -0.35 7.67e-11 Coronary artery disease; LUSC trans rs11098499 0.954 rs17046116 chr4:120387259 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.05e-9 Corneal astigmatism; LUSC cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.22 0.37 3.45e-12 Motion sickness; LUSC cis rs1062746 0.544 rs17770933 chr16:87325729 C/T cg02258303 chr16:87377426 FBXO31 -0.51 -7.54 -0.38 4.35e-13 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs1538970 0.924 rs1494812 chr1:45876999 C/T cg06784218 chr1:46089804 CCDC17 0.32 5.71 0.3 2.51e-8 Platelet count; LUSC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg04455712 chr21:45112962 RRP1B 0.48 8.88 0.44 4.18e-17 Mean corpuscular volume; LUSC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg09365446 chr1:150670422 GOLPH3L -0.52 -7.57 -0.38 3.76e-13 Blood protein levels; LUSC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg20243544 chr17:37824526 PNMT 0.38 5.67 0.3 3.11e-8 Self-reported allergy; LUSC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg10523679 chr1:76189770 ACADM -0.87 -14.25 -0.61 2.61e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg18721089 chr20:30220636 NA -0.36 -6.2 -0.32 1.71e-9 Mean corpuscular hemoglobin; LUSC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg21017887 chr14:105400489 NA 0.69 13.26 0.59 1.5e-32 Rheumatoid arthritis; LUSC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg15704280 chr7:45808275 SEPT13 1.03 17.76 0.7 3.6e-50 Height; LUSC cis rs6121246 0.821 rs6119718 chr20:30331074 A/G cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC trans rs853679 0.513 rs13437444 chr6:28070998 C/T cg06606381 chr12:133084897 FBRSL1 -0.52 -6.26 -0.32 1.18e-9 Depression; LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.71 12.06 0.55 4.64e-28 Prudent dietary pattern; LUSC cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg05283184 chr6:79620031 NA -0.54 -11.17 -0.52 7.97e-25 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg05665937 chr4:1216051 CTBP1 -0.37 -5.73 -0.3 2.19e-8 Obesity-related traits; LUSC cis rs1160297 0.609 rs1376563 chr2:53104749 C/G cg07782112 chr2:53107842 NA 0.39 6.59 0.34 1.76e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg11366901 chr6:160182831 ACAT2 0.94 13.17 0.58 3.5e-32 Age-related macular degeneration (geographic atrophy); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08729914 chr12:64845936 TBK1 -0.49 -6.27 -0.32 1.13e-9 Bipolar disorder and schizophrenia; LUSC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg07157834 chr1:205819609 PM20D1 -0.41 -5.81 -0.3 1.43e-8 Parkinson's disease; LUSC cis rs3020736 0.500 rs6002614 chr22:42501802 G/A cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7043114 0.525 rs7020874 chr9:95112560 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.72 -0.35 7.86e-11 Height; LUSC cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.5 -5.74 -0.3 2.15e-8 Schizophrenia; LUSC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg09365446 chr1:150670422 GOLPH3L -0.48 -7.0 -0.36 1.44e-11 Melanoma; LUSC cis rs963731 0.737 rs10194374 chr2:39244914 G/A cg04010122 chr2:39346883 SOS1 -0.82 -5.74 -0.3 2.11e-8 Corticobasal degeneration; LUSC cis rs4654899 0.802 rs10493004 chr1:21442736 T/C cg01072550 chr1:21505969 NA -0.5 -7.51 -0.38 5.6e-13 Superior frontal gyrus grey matter volume; LUSC cis rs8141529 0.509 rs5762853 chr22:29245231 T/G cg02153584 chr22:29168773 CCDC117 0.54 7.94 0.4 3.05e-14 Lymphocyte counts; LUSC cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.73 11.45 0.53 7.9e-26 Colorectal cancer; LUSC cis rs9399135 0.967 rs4896119 chr6:135293391 C/T cg24558204 chr6:135376177 HBS1L 0.58 8.97 0.44 2.14e-17 Red blood cell count; LUSC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg15605315 chr1:45957053 TESK2 0.51 8.44 0.42 9.79e-16 High light scatter reticulocyte count; LUSC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16744862 chr16:1823033 MRPS34;NME3;EME2 -0.42 -6.24 -0.32 1.36e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs116988415 0.539 rs11623956 chr14:65270391 G/A cg00114569 chr14:65239327 SPTB 0.69 7.64 0.39 2.28e-13 Daytime sleep phenotypes; LUSC cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg05347473 chr6:146136440 FBXO30 -0.46 -7.64 -0.39 2.35e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6541297 1.000 rs6681042 chr1:230278979 G/A cg05784532 chr1:230284198 GALNT2 0.49 7.39 0.38 1.16e-12 Coronary artery disease; LUSC cis rs9399401 0.626 rs1928528 chr6:142779109 T/G cg03128060 chr6:142623767 GPR126 0.58 9.63 0.47 1.55e-19 Chronic obstructive pulmonary disease; LUSC trans rs1325195 0.879 rs9729199 chr1:179092613 G/C cg11624085 chr17:8464688 MYH10 -0.43 -7.2 -0.37 4.05e-12 IgE grass sensitization; LUSC cis rs4343996 0.967 rs7811244 chr7:3342276 G/A cg21248987 chr7:3385318 SDK1 0.39 6.56 0.34 2.08e-10 Motion sickness; LUSC cis rs4363385 0.553 rs1415972 chr1:152953552 A/G cg25856811 chr1:152973957 SPRR3 0.35 6.01 0.31 4.97e-9 Inflammatory skin disease; LUSC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg11890956 chr21:40555474 PSMG1 1.03 19.71 0.73 6.47e-58 Cognitive function; LUSC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg08847533 chr14:75593920 NEK9 0.85 15.55 0.65 2.07e-41 Height; LUSC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC cis rs8017423 1.000 rs769044 chr14:90671138 A/G cg04374321 chr14:90722782 PSMC1 0.67 10.55 0.5 1.15e-22 Mortality in heart failure; LUSC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg05802129 chr4:122689817 NA -0.5 -8.12 -0.41 9.17e-15 Type 2 diabetes; LUSC cis rs34172651 0.917 rs12599643 chr16:24832693 C/T cg00339695 chr16:24857497 SLC5A11 0.37 6.5 0.34 2.96e-10 Intelligence (multi-trait analysis); LUSC cis rs4588572 0.643 rs10068686 chr5:77795220 C/T cg11547950 chr5:77652471 NA -0.57 -8.06 -0.4 1.34e-14 Triglycerides; LUSC cis rs11031096 0.655 rs10835695 chr11:4178962 G/T cg18678763 chr11:4115507 RRM1 -0.4 -5.64 -0.3 3.54e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs12200782 1.000 rs72843802 chr6:26517515 C/T cg11837749 chr1:55047332 ACOT11 0.58 6.31 0.33 8.85e-10 Small cell lung carcinoma; LUSC cis rs1775715 0.707 rs2799024 chr10:32166922 A/G cg03015672 chr10:32216066 ARHGAP12 0.34 6.22 0.32 1.49e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs870825 1.000 rs72689245 chr4:185579788 G/A cg04058563 chr4:185651563 MLF1IP 0.85 11.46 0.53 7e-26 Blood protein levels; LUSC cis rs6967385 0.560 rs10279958 chr7:12350593 T/C cg06484146 chr7:12443880 VWDE 0.42 6.25 0.32 1.25e-9 Response to taxane treatment (placlitaxel); LUSC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg14664628 chr15:75095509 CSK -0.55 -8.46 -0.42 8.72e-16 Breast cancer; LUSC cis rs9473147 0.516 rs10456570 chr6:47559451 A/G cg20196966 chr6:47445060 CD2AP 0.41 5.75 0.3 2.07e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg12257692 chr3:49977190 RBM6 0.26 7.05 0.36 1.05e-11 Intelligence (multi-trait analysis); LUSC cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg23093090 chr10:104574429 C10orf26 -0.4 -6.39 -0.33 5.44e-10 Arsenic metabolism; LUSC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg16680214 chr1:154839983 KCNN3 0.36 6.42 0.33 4.7e-10 Schizophrenia; LUSC cis rs7246657 0.943 rs2303131 chr19:37936025 G/A cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg13647721 chr17:30228624 UTP6 -0.62 -5.93 -0.31 7.76e-9 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg08219700 chr8:58056026 NA 0.49 6.06 0.31 3.61e-9 Developmental language disorder (linguistic errors); LUSC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg25282410 chr6:160211355 TCP1;MRPL18 -1.05 -16.05 -0.66 2.22e-43 Age-related macular degeneration (geographic atrophy); LUSC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg06873352 chr17:61820015 STRADA 0.57 8.85 0.44 5.07e-17 Height; LUSC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg10523679 chr1:76189770 ACADM 0.9 14.18 0.61 4.9e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2997447 0.655 rs11247852 chr1:26383125 C/G cg19633962 chr1:26362018 EXTL1 0.54 6.39 0.33 5.55e-10 QRS complex (12-leadsum); LUSC cis rs4746818 0.892 rs12437 chr10:70864065 T/C cg11621586 chr10:70884670 VPS26A 1.04 11.74 0.54 6.76e-27 Left atrial antero-posterior diameter; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg11808746 chr10:95256359 CEP55 -0.43 -6.6 -0.34 1.62e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs877282 0.533 rs10904565 chr10:819991 G/T cg13775593 chr10:823151 NA 0.28 5.76 0.3 1.91e-8 Uric acid levels; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.83 0.39 6.5e-14 Bipolar disorder; LUSC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg09555818 chr19:45449301 APOC2 0.46 8.84 0.44 5.73e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12594515 1.000 rs8038058 chr15:45990272 C/T cg01629716 chr15:45996671 NA 0.4 6.02 0.31 4.54e-9 Waist circumference;Weight; LUSC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg24578937 chr1:2090814 PRKCZ 0.38 8.21 0.41 4.9e-15 Coronary artery disease; LUSC trans rs724744 0.875 rs1205893 chr6:22344369 A/G cg13807341 chr11:118445984 ARCN1 -0.38 -6.28 -0.32 1.03e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs3859192 0.577 rs2227333 chr17:38174167 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.7 12.23 0.56 1.17e-28 White blood cell count; LUSC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.04 15.66 0.65 8.17e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg07507251 chr3:52567010 NT5DC2 0.34 6.61 0.34 1.5e-10 Bipolar disorder; LUSC cis rs7617480 0.648 rs9284885 chr3:48883100 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.95 0.48 1.38e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg12011299 chr4:100065546 ADH4 0.72 10.69 0.5 4.02e-23 Smoking initiation; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg22907277 chr7:1156413 C7orf50 0.39 6.01 0.31 4.85e-9 Longevity;Endometriosis; LUSC cis rs2760061 0.819 rs3094913 chr1:228206980 T/C cg02753203 chr1:228287806 NA 0.72 12.56 0.57 6.61e-30 Diastolic blood pressure; LUSC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg11247378 chr22:39784982 NA -0.64 -11.46 -0.53 6.98e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6700559 0.740 rs10919997 chr1:200646650 C/T cg07804481 chr1:200639085 DDX59 0.41 5.77 0.3 1.85e-8 Coronary artery disease; LUSC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg13114125 chr14:105738426 BRF1 -0.9 -14.9 -0.63 7.45e-39 Mean platelet volume;Platelet distribution width; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC trans rs8073060 0.586 rs225265 chr17:33961972 C/T cg19694781 chr19:47549865 TMEM160 -1.13 -18.15 -0.7 1.04e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs28735056 0.592 rs10853392 chr18:77708781 A/G cg05926928 chr17:57297772 GDPD1 -0.43 -6.28 -0.32 1.04e-9 Schizophrenia; LUSC cis rs3733585 0.638 rs13145554 chr4:9979589 C/T cg11266682 chr4:10021025 SLC2A9 0.5 9.21 0.45 3.65e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg07167872 chr1:205819463 PM20D1 0.99 23.37 0.79 2.92e-72 Menarche (age at onset); LUSC cis rs11718455 0.548 rs11918413 chr3:43902518 C/A cg08738300 chr3:44038990 NA -0.59 -8.64 -0.43 2.44e-16 Coronary artery disease; LUSC cis rs6554196 0.525 rs12504135 chr4:55505933 A/T cg18836493 chr4:55524333 KIT -0.43 -7.58 -0.38 3.37e-13 Monocyte count; LUSC cis rs9341808 0.667 rs3805913 chr6:80927322 A/G cg08355045 chr6:80787529 NA 0.48 8.12 0.41 9.06e-15 Sitting height ratio; LUSC cis rs587080 0.624 rs512715 chr11:65191208 C/G cg17120908 chr11:65337727 SSSCA1 0.44 6.9 0.35 2.61e-11 Plateletcrit; LUSC cis rs5758659 1.000 rs5758660 chr22:42623718 C/A cg04733989 chr22:42467013 NAGA 0.4 6.41 0.33 5.09e-10 Cognitive function; LUSC trans rs12210905 0.920 rs9366690 chr6:27291079 T/C cg11837749 chr1:55047332 ACOT11 0.66 6.3 0.33 9.13e-10 Hip circumference adjusted for BMI; LUSC cis rs2404602 0.684 rs965818 chr15:76866785 T/C cg23625390 chr15:77176239 SCAPER -0.65 -9.97 -0.48 1.12e-20 Blood metabolite levels; LUSC cis rs11690935 0.959 rs1474074 chr2:172659852 G/A cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.49 -0.62 2.85e-37 Schizophrenia; LUSC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg21433313 chr16:3507492 NAT15 -0.67 -11.23 -0.52 4.68e-25 Tuberculosis; LUSC cis rs7927771 0.839 rs3817334 chr11:47650993 C/T cg20135002 chr11:47629003 NA -0.41 -6.61 -0.34 1.5e-10 Subjective well-being; LUSC cis rs35883536 0.647 rs2783696 chr1:101044089 G/A cg06223162 chr1:101003688 GPR88 0.5 9.47 0.46 5.25e-19 Monocyte count; LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03934478 chr11:495069 RNH1 0.91 10.53 0.5 1.39e-22 Body mass index; LUSC cis rs612683 0.764 rs558035 chr1:100939777 T/C cg06223162 chr1:101003688 GPR88 -0.47 -8.48 -0.42 7.34e-16 Breast cancer; LUSC cis rs11018904 0.861 rs61903723 chr11:89968246 C/T cg26834418 chr11:89957033 CHORDC1 -0.49 -6.01 -0.31 4.8e-9 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.967 rs6923827 chr6:135335382 C/T cg24558204 chr6:135376177 HBS1L 0.58 8.81 0.43 6.87e-17 Red blood cell count; LUSC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg26395211 chr5:140044315 WDR55 0.45 7.0 0.36 1.39e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs6951245 0.882 rs10252404 chr7:1209607 C/A cg22907277 chr7:1156413 C7orf50 0.64 6.74 0.35 6.9e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9311676 0.656 rs11923253 chr3:58376992 G/A cg13750441 chr3:58318267 PXK 0.36 6.95 0.36 1.91e-11 Systemic lupus erythematosus; LUSC cis rs1865760 0.964 rs3799373 chr6:25929173 A/C cg16482183 chr6:26056742 HIST1H1C 0.45 6.58 0.34 1.81e-10 Height; LUSC cis rs12908161 0.959 rs61074241 chr15:85333396 C/T cg11189052 chr15:85197271 WDR73 0.54 6.43 0.33 4.5e-10 Schizophrenia; LUSC cis rs853679 0.546 rs34194357 chr6:27818535 A/G cg26958806 chr6:27640298 NA 0.83 6.57 0.34 1.94e-10 Depression; LUSC cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg13256891 chr4:100009986 ADH5 0.5 7.3 0.37 2.18e-12 Alcohol dependence; LUSC cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg05535760 chr7:792225 HEATR2 0.79 9.46 0.46 5.56e-19 Cerebrospinal P-tau181p levels; LUSC cis rs4843185 0.733 rs1049868 chr16:85706633 A/G cg26571870 chr16:85723150 GINS2 -0.32 -5.88 -0.31 1e-8 Platelet distribution width; LUSC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg24838063 chr12:130822603 PIWIL1 0.71 11.02 0.52 2.71e-24 Menopause (age at onset); LUSC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg21984481 chr17:79567631 NPLOC4 0.58 11.22 0.52 5.07e-25 Eye color traits; LUSC cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg16850897 chr7:100343110 ZAN 0.37 5.81 0.3 1.46e-8 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs73198271 0.603 rs557892 chr8:8596048 A/C cg15556689 chr8:8085844 FLJ10661 -0.46 -5.82 -0.3 1.4e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1580019 0.961 rs766657 chr7:32499510 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.79 11.9 0.55 1.79e-27 Cognitive ability; LUSC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg08677398 chr8:58056175 NA 0.61 6.96 0.36 1.81e-11 Developmental language disorder (linguistic errors); LUSC cis rs4595586 0.545 rs1303886 chr12:39366876 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs17253792 0.732 rs75796044 chr14:56034128 C/T cg01858014 chr14:56050164 KTN1 -0.75 -6.41 -0.33 4.87e-10 Putamen volume; LUSC cis rs9900972 0.918 rs4789940 chr17:76877671 G/T cg20937029 chr17:76870563 TIMP2 0.38 5.96 0.31 6.38e-9 Obesity-related traits; LUSC cis rs950027 0.549 rs12909409 chr15:45608582 T/G cg26924012 chr15:45694286 SPATA5L1 -0.77 -11.51 -0.53 4.93e-26 Response to fenofibrate (adiponectin levels); LUSC cis rs7246657 0.943 rs13343502 chr19:37962292 C/T cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC trans rs17685 0.712 rs4732578 chr7:75721532 A/G cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.78e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg00149659 chr3:10157352 C3orf10 0.64 9.07 0.44 1.04e-17 Alzheimer's disease; LUSC cis rs9322817 0.691 rs56075147 chr6:105337494 T/A cg02098413 chr6:105308735 HACE1 0.28 5.96 0.31 6.53e-9 Thyroid stimulating hormone; LUSC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg13206674 chr6:150067644 NUP43 0.6 9.37 0.46 1.12e-18 Lung cancer; LUSC cis rs11792861 0.781 rs17729408 chr9:111740860 A/G cg05043794 chr9:111880884 C9orf5 0.35 7.48 0.38 6.81e-13 Menarche (age at onset); LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg03188948 chr7:1209495 NA 0.44 6.44 0.33 4.19e-10 Longevity;Endometriosis; LUSC cis rs17125944 0.505 rs17125746 chr14:53236079 C/T cg00686598 chr14:53173677 PSMC6 1.13 9.68 0.47 1.06e-19 Alzheimer's disease (late onset); LUSC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg07837209 chr13:79184101 NA -0.44 -6.55 -0.34 2.16e-10 Large artery stroke; LUSC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.46e-10 Total body bone mineral density; LUSC cis rs7189233 0.531 rs13337544 chr16:53519035 T/C cg09728985 chr16:53543985 NA -0.3 -5.67 -0.3 3.09e-8 Intelligence (multi-trait analysis); LUSC cis rs6121246 0.529 rs6060195 chr20:30185638 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs6500395 1.000 rs9930199 chr16:48571263 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.69 0.34 9.38e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6574644 1.000 rs12588160 chr14:81776666 T/G cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs2797160 0.967 rs1777182 chr6:126013614 T/A cg05901451 chr6:126070800 HEY2 0.57 8.61 0.43 2.83e-16 Endometrial cancer; LUSC cis rs13108904 0.870 rs2335855 chr4:1237968 T/C cg16405210 chr4:1374714 KIAA1530 -0.55 -8.48 -0.42 7.41e-16 Obesity-related traits; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg03461704 chr1:205818484 PM20D1 0.41 6.93 0.35 2.23e-11 Menarche (age at onset); LUSC cis rs67460515 0.531 rs1585483 chr3:160843111 G/A cg03342759 chr3:160939853 NMD3 -0.45 -6.22 -0.32 1.53e-9 Parkinson's disease; LUSC cis rs1451375 1.000 rs1451375 chr7:50622712 A/C cg18232548 chr7:50535776 DDC -0.53 -8.32 -0.41 2.33e-15 Malaria; LUSC cis rs10823500 0.777 rs7919014 chr10:71944577 T/C cg02100629 chr10:71892760 AIFM2 -0.4 -6.44 -0.33 4.16e-10 Blood protein levels; LUSC cis rs983392 0.680 rs56357056 chr11:59986817 A/G cg20284999 chr11:59952153 MS4A6A -0.37 -6.14 -0.32 2.38e-9 Alzheimer's disease (late onset); LUSC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg08859206 chr1:53392774 SCP2 0.4 6.5 0.34 2.96e-10 Monocyte count; LUSC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.93 0.35 2.24e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1568889 0.838 rs7125749 chr11:28154692 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.66 0.57 2.85e-30 Bipolar disorder; LUSC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.24 0.52 4.35e-25 Menopause (age at onset); LUSC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg08470875 chr2:26401718 FAM59B -0.68 -9.16 -0.45 5.3e-18 Gut microbiome composition (summer); LUSC cis rs7107174 0.892 rs4944196 chr11:78008731 G/A cg02023728 chr11:77925099 USP35 0.49 6.87 0.35 3.11e-11 Testicular germ cell tumor; LUSC cis rs4285028 0.699 rs1574115 chr3:121469225 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.24 -0.56 1.02e-28 Multiple sclerosis; LUSC cis rs300890 0.651 rs300917 chr4:144269849 C/G cg01601573 chr4:144256835 GAB1 -0.29 -5.68 -0.3 2.87e-8 Nasopharyngeal carcinoma; LUSC cis rs4808199 0.948 rs12982276 chr19:19459800 T/C cg03709012 chr19:19516395 GATAD2A 0.97 12.18 0.55 1.66e-28 Nonalcoholic fatty liver disease; LUSC cis rs35883536 0.967 rs1055044 chr1:101171354 A/G cg06223162 chr1:101003688 GPR88 0.31 5.64 0.3 3.57e-8 Monocyte count; LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg12564285 chr5:131593104 PDLIM4 0.56 10.79 0.51 1.81e-23 Acylcarnitine levels; LUSC cis rs9296092 0.538 rs75082458 chr6:33524792 C/T cg13560919 chr6:33536144 NA -0.83 -15.86 -0.66 1.3e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7474896 0.559 rs2753880 chr10:38173338 G/A cg25427524 chr10:38739819 LOC399744 0.45 5.9 0.31 8.86e-9 Obesity (extreme); LUSC cis rs6598955 0.543 rs6690461 chr1:26543097 T/A cg04990556 chr1:26633338 UBXN11 0.85 11.14 0.52 9.76e-25 Obesity-related traits; LUSC cis rs2797160 0.602 rs4897150 chr6:125985540 C/T cg05901451 chr6:126070800 HEY2 -0.6 -9.24 -0.45 3.07e-18 Endometrial cancer; LUSC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg20818283 chr2:191399100 TMEM194B 0.46 7.02 0.36 1.26e-11 Pulse pressure; LUSC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg08088566 chr11:430123 ANO9 -0.64 -7.44 -0.38 8.51e-13 Body mass index; LUSC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg13395646 chr4:1353034 KIAA1530 -0.63 -9.84 -0.47 3.24e-20 Obesity-related traits; LUSC cis rs2729354 0.768 rs2848640 chr11:57262680 A/G cg24343310 chr11:57249947 NA 0.46 8.49 0.42 6.92e-16 Blood protein levels; LUSC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg20887711 chr4:1340912 KIAA1530 0.54 8.51 0.42 5.91e-16 Longevity; LUSC cis rs1577917 1.000 rs34852683 chr6:86702330 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.19 -0.41 5.58e-15 Response to antipsychotic treatment; LUSC cis rs7264396 0.563 rs2425086 chr20:34302873 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.56 -0.42 4.24e-16 Total cholesterol levels; LUSC trans rs1493916 0.837 rs10401087 chr18:31320716 A/G cg27147174 chr7:100797783 AP1S1 -0.54 -8.41 -0.42 1.2e-15 Life satisfaction; LUSC cis rs2404602 0.552 rs11630185 chr15:76959783 A/T cg23625390 chr15:77176239 SCAPER -0.61 -8.72 -0.43 1.31e-16 Blood metabolite levels; LUSC cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg23173402 chr1:227635558 NA 0.59 7.08 0.36 8.53e-12 Major depressive disorder; LUSC cis rs9837602 1.000 rs2291495 chr3:99782227 T/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.82 -0.3 1.38e-8 Breast cancer; LUSC cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.36 -0.37 1.47e-12 Menopause (age at onset); LUSC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg04871131 chr7:94954202 PON1 -0.37 -5.97 -0.31 6.14e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg09904177 chr6:26538194 HMGN4 0.42 6.14 0.32 2.41e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs5769707 0.681 rs4824068 chr22:50024801 G/A cg10356904 chr22:49881777 NA -0.29 -5.86 -0.31 1.12e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg16797656 chr11:68205561 LRP5 0.4 7.26 0.37 2.67e-12 Total body bone mineral density; LUSC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg11062466 chr8:58055876 NA 0.67 7.68 0.39 1.81e-13 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.680 rs78402272 chr3:42028425 G/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs7786808 0.778 rs34212455 chr7:158224490 C/T cg09998033 chr7:158218633 PTPRN2 -0.62 -9.87 -0.48 2.57e-20 Obesity-related traits; LUSC cis rs6138458 0.546 rs6050118 chr20:24891895 C/T cg06937882 chr20:24974362 C20orf3 0.47 6.46 0.33 3.8e-10 Blood protein levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg01366246 chr3:193852768 HES1 0.44 6.2 0.32 1.64e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg25258033 chr6:167368657 RNASET2 0.44 7.05 0.36 1.06e-11 Crohn's disease; LUSC trans rs60843830 0.661 rs62116682 chr2:104618 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.51 8.01 0.4 1.94e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs921968 0.545 rs2433738 chr2:219551036 T/A cg02176678 chr2:219576539 TTLL4 -0.59 -10.42 -0.5 3.24e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs1448094 0.935 rs4919775 chr12:86339985 T/C cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.56e-9 Major depressive disorder; LUSC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg27494647 chr7:150038898 RARRES2 0.58 8.37 0.42 1.55e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs11098499 0.954 rs11734241 chr4:120416872 A/G cg24375607 chr4:120327624 NA 0.79 12.03 0.55 6.08e-28 Corneal astigmatism; LUSC cis rs7586879 1.000 rs11683212 chr2:25120196 T/C cg04586622 chr2:25135609 ADCY3 0.32 6.24 0.32 1.35e-9 Body mass index; LUSC cis rs9311676 0.609 rs1126551 chr3:58416535 C/T cg26110898 chr3:58419937 PDHB 0.4 6.4 0.33 5.22e-10 Systemic lupus erythematosus; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg08219531 chr3:72495966 RYBP 0.42 6.37 0.33 6.13e-10 N-glycan levels; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg13646470 chr14:89291237 TTC8 0.52 6.48 0.33 3.25e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7520050 0.778 rs2088102 chr1:46032974 T/C cg15605315 chr1:45957053 TESK2 0.4 6.03 0.31 4.41e-9 Red blood cell count;Reticulocyte count; LUSC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg16414030 chr3:133502952 NA -0.42 -6.51 -0.34 2.69e-10 Iron status biomarkers; LUSC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg14196790 chr5:131705035 SLC22A5 0.49 8.4 0.42 1.28e-15 Blood metabolite levels; LUSC cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 29.35 0.85 1.65e-94 Chronic sinus infection; LUSC cis rs9527 0.545 rs7100369 chr10:104956218 C/A cg05855489 chr10:104503620 C10orf26 0.51 7.9 0.4 3.95e-14 Arsenic metabolism; LUSC cis rs34779708 0.966 rs12784482 chr10:35446865 A/G cg03585969 chr10:35415529 CREM 0.61 8.85 0.44 5.02e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg16145915 chr7:1198662 ZFAND2A -0.48 -9.01 -0.44 1.61e-17 Longevity;Endometriosis; LUSC trans rs17685 0.535 rs41296542 chr7:75600008 A/G cg19862616 chr7:65841803 NCRNA00174 0.46 6.18 0.32 1.85e-9 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1982963 0.627 rs8013745 chr14:52496745 G/T cg10843707 chr14:52510701 NID2 0.47 6.3 0.33 9.55e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.36 0.53 1.6e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.837 rs8142737 chr22:50291889 T/C cg08270630 chr22:50330655 NA -0.41 -6.2 -0.32 1.71e-9 Schizophrenia; LUSC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg11764359 chr7:65958608 NA 0.7 10.74 0.51 2.63e-23 Aortic root size; LUSC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg03477792 chr4:77819574 ANKRD56 0.62 8.86 0.44 4.88e-17 Emphysema distribution in smoking; LUSC cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.14e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg22433210 chr17:43662623 NA 0.94 13.36 0.59 6.3e-33 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs12594515 1.000 rs58368732 chr15:45990531 G/C cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC trans rs7824557 0.815 rs2736372 chr8:11106041 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.63 -0.34 1.38e-10 Retinal vascular caliber; LUSC cis rs6967385 0.580 rs10258717 chr7:12331651 A/G cg20607287 chr7:12443886 VWDE 0.36 5.75 0.3 2.02e-8 Response to taxane treatment (placlitaxel); LUSC cis rs1560104 0.665 rs4381587 chr16:12702904 G/C cg02946846 chr16:12632861 SNX29 0.32 5.88 0.31 1.02e-8 Obesity-related traits; LUSC cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg15073853 chr19:18549131 ISYNA1 -0.32 -5.66 -0.3 3.26e-8 Breast cancer; LUSC cis rs6906287 0.647 rs11153753 chr6:118836153 T/C cg21191810 chr6:118973309 C6orf204 0.32 5.83 0.3 1.27e-8 Electrocardiographic conduction measures; LUSC cis rs599083 0.530 rs2508834 chr11:68175354 C/T cg01657329 chr11:68192670 LRP5 0.5 6.64 0.34 1.24e-10 Bone mineral density (spine); LUSC cis rs55910451 0.723 rs72774078 chr10:5768140 A/G cg11519256 chr10:5708881 ASB13 -0.48 -5.81 -0.3 1.47e-8 Breast cancer; LUSC cis rs6918586 0.658 rs198843 chr6:26110314 A/T cg17691542 chr6:26056736 HIST1H1C 0.41 6.08 0.32 3.25e-9 Schizophrenia; LUSC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg15445000 chr17:37608096 MED1 -0.39 -6.72 -0.35 7.97e-11 Glomerular filtration rate (creatinine); LUSC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg16797656 chr11:68205561 LRP5 0.36 6.08 0.32 3.36e-9 Total body bone mineral density; LUSC trans rs2514895 0.660 rs7925233 chr11:127113327 C/A cg22738642 chr12:43137977 NA 0.5 6.26 0.32 1.17e-9 IgG glycosylation; LUSC cis rs1775715 0.677 rs2808074 chr10:32179184 A/C cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.65e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9393692 0.905 rs2393592 chr6:26285560 A/G cg00631329 chr6:26305371 NA -0.46 -8.95 -0.44 2.49e-17 Educational attainment; LUSC cis rs4363385 0.669 rs4845519 chr1:153003916 G/T cg25856811 chr1:152973957 SPRR3 0.34 5.76 0.3 1.87e-8 Inflammatory skin disease; LUSC cis rs10740039 0.516 rs2393675 chr10:62350748 T/G cg18175470 chr10:62150864 ANK3 -0.47 -6.82 -0.35 4.35e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11650494 0.710 rs16948078 chr17:47474800 C/T cg08112188 chr17:47440006 ZNF652 -0.83 -7.59 -0.38 3.15e-13 Prostate cancer; LUSC cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.51 -0.46 4.02e-19 Chronic sinus infection; LUSC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg14416269 chr4:6271139 WFS1 0.5 10.62 0.5 6.83e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2658782 0.756 rs3019205 chr11:93109553 A/G cg15737290 chr11:93063684 CCDC67 0.63 7.77 0.39 9.47e-14 Pulmonary function decline; LUSC cis rs72901758 0.768 rs1567237 chr17:76246294 A/G cg26068271 chr17:76253126 NA -0.59 -10.55 -0.5 1.17e-22 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9650657 0.571 rs11783247 chr8:10788875 C/T cg21775007 chr8:11205619 TDH -0.5 -7.04 -0.36 1.08e-11 Neuroticism; LUSC cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg02753203 chr1:228287806 NA -0.66 -11.1 -0.52 1.36e-24 Diastolic blood pressure; LUSC trans rs877282 0.853 rs10904545 chr10:757100 G/A cg22713356 chr15:30763199 NA 1.03 13.58 0.6 9.8e-34 Uric acid levels; LUSC cis rs9457247 0.967 rs1794696 chr6:167396174 T/C cg20406979 chr6:167373233 NA 0.26 6.02 0.31 4.59e-9 Crohn's disease; LUSC cis rs4285028 0.580 rs1523519 chr3:121631841 C/T cg20356878 chr3:121714668 ILDR1 -0.44 -6.7 -0.34 8.97e-11 Multiple sclerosis; LUSC cis rs453301 0.631 rs28572014 chr8:8793607 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -6.07 -0.32 3.46e-9 Joint mobility (Beighton score); LUSC cis rs9653442 0.564 rs4851256 chr2:100775045 A/G cg07810366 chr2:100720526 AFF3 -0.41 -6.96 -0.36 1.81e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs9341835 0.772 rs9294197 chr6:64135648 A/G cg00787780 chr6:64151745 NA -0.33 -5.77 -0.3 1.82e-8 Schizophrenia; LUSC cis rs425277 1.000 rs262665 chr1:2083173 A/G cg24578937 chr1:2090814 PRKCZ 0.6 13.84 0.6 9.47e-35 Height; LUSC cis rs2274273 0.934 rs17740741 chr14:55762712 G/C cg04306507 chr14:55594613 LGALS3 0.54 12.17 0.55 1.88e-28 Protein biomarker; LUSC cis rs6977660 0.714 rs4719586 chr7:19825548 T/C cg05791153 chr7:19748676 TWISTNB 0.67 6.93 0.35 2.24e-11 Thyroid stimulating hormone; LUSC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg15704280 chr7:45808275 SEPT13 0.66 7.26 0.37 2.77e-12 Axial length; LUSC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg09955084 chr16:413813 NA 0.27 5.86 0.31 1.1e-8 Bone mineral density (spine);Bone mineral density; LUSC trans rs208520 1.000 rs12212063 chr6:66985148 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.83 0.54 3.22e-27 Exhaled nitric oxide output; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg06873352 chr17:61820015 STRADA 0.71 12.79 0.57 9.66e-31 Prudent dietary pattern; LUSC cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.19 -0.32 1.79e-9 IgG glycosylation; LUSC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg11764359 chr7:65958608 NA -0.53 -6.9 -0.35 2.67e-11 Aortic root size; LUSC cis rs3862030 0.720 rs11595149 chr10:104235978 C/T cg05855489 chr10:104503620 C10orf26 0.51 7.85 0.39 5.62e-14 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs9341808 0.718 rs3812121 chr6:80968727 A/G cg08355045 chr6:80787529 NA 0.56 9.62 0.47 1.64e-19 Sitting height ratio; LUSC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg27398817 chr8:82754497 SNX16 -0.45 -5.99 -0.31 5.29e-9 Diastolic blood pressure; LUSC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg03433033 chr1:76189801 ACADM 0.71 9.09 0.45 8.67e-18 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs921665 0.831 rs2368672 chr2:3188893 A/C cg02624386 chr2:3182749 NA 0.59 6.59 0.34 1.68e-10 World class endurance athleticism; LUSC cis rs34638657 0.656 rs1134847 chr16:82203742 C/T cg09439754 chr16:82129088 HSD17B2 0.39 6.53 0.34 2.4e-10 Lung adenocarcinoma; LUSC cis rs10423674 0.526 rs2023878 chr19:18834124 A/G cg14292368 chr19:18793705 CRTC1 0.44 6.73 0.35 7.54e-11 Menarche (age at onset); LUSC cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg12549451 chr6:135224345 NA 0.35 5.78 0.3 1.71e-8 Red blood cell count; LUSC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg09267113 chr7:98030324 BAIAP2L1 0.4 5.95 0.31 6.93e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1506636 0.512 rs1035015 chr7:123309842 G/C cg03229431 chr7:123269106 ASB15 0.59 7.97 0.4 2.52e-14 Plateletcrit;Platelet count; LUSC cis rs7843479 0.509 rs3758156 chr8:21770796 A/G cg17168535 chr8:21777572 XPO7 0.69 11.68 0.54 1.12e-26 Mean corpuscular volume; LUSC trans rs11098499 0.863 rs6833334 chr4:120504227 C/T cg25214090 chr10:38739885 LOC399744 0.54 8.06 0.4 1.42e-14 Corneal astigmatism; LUSC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg08085267 chr17:45401833 C17orf57 -0.45 -6.49 -0.33 3.19e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2832191 0.716 rs1543652 chr21:30448000 G/C cg14791747 chr16:20752902 THUMPD1 -0.41 -6.2 -0.32 1.65e-9 Dental caries; LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9309473 0.519 rs4852951 chr2:73869796 C/G cg20560298 chr2:73613845 ALMS1 0.46 6.96 0.36 1.84e-11 Metabolite levels; LUSC cis rs433852 0.718 rs386551 chr19:49138286 C/G cg06677660 chr19:49140777 SEC1;DBP -0.46 -6.0 -0.31 5e-9 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs60843830 0.928 rs62114494 chr2:211317 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.52 8.0 0.4 2.1e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1908814 0.516 rs56102998 chr8:11796675 G/A cg00262122 chr8:11665843 FDFT1 0.4 5.9 0.31 8.84e-9 Neuroticism; LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.47 -0.38 6.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2455601 0.786 rs11042127 chr11:8947586 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -7.26 -0.37 2.74e-12 Schizophrenia; LUSC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.93 -0.35 2.18e-11 Lung cancer; LUSC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg17554472 chr22:41940697 POLR3H -0.47 -5.69 -0.3 2.76e-8 Vitiligo; LUSC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.73 0.51 2.84e-23 Menopause (age at onset); LUSC cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.32 0.33 8.57e-10 Rheumatoid arthritis; LUSC cis rs12701220 0.894 rs2141274 chr7:1034717 G/A cg00990874 chr7:1149470 C7orf50 -0.49 -6.19 -0.32 1.72e-9 Bronchopulmonary dysplasia; LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg02475777 chr4:1388615 CRIPAK 0.45 6.86 0.35 3.37e-11 Obesity-related traits; LUSC cis rs806215 1.000 rs2106187 chr7:127241353 C/T cg25922125 chr7:127225783 GCC1 0.57 7.16 0.36 5.26e-12 Type 2 diabetes; LUSC cis rs977987 0.815 rs4887829 chr16:75488935 C/T cg03315344 chr16:75512273 CHST6 0.54 10.63 0.5 6.49e-23 Dupuytren's disease; LUSC cis rs11030122 0.733 rs10835331 chr11:3957365 C/T cg18678763 chr11:4115507 RRM1 -0.43 -5.73 -0.3 2.23e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs67460515 0.892 rs4856769 chr3:161004549 C/A cg03342759 chr3:160939853 NMD3 -0.54 -7.75 -0.39 1.09e-13 Parkinson's disease; LUSC cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7843479 0.601 rs2002941 chr8:21834366 A/C cg17168535 chr8:21777572 XPO7 0.84 15.66 0.65 7.57e-42 Mean corpuscular volume; LUSC cis rs9303401 0.592 rs12936771 chr17:56725052 T/C cg25039879 chr17:56429692 SUPT4H1 0.64 8.67 0.43 1.92e-16 Cognitive test performance; LUSC cis rs950027 0.596 rs2467853 chr15:45698793 T/G cg21132104 chr15:45694354 SPATA5L1 0.39 5.72 0.3 2.36e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs826838 0.585 rs12296822 chr12:38625829 A/T cg13010199 chr12:38710504 ALG10B -0.45 -6.75 -0.35 6.46e-11 Heart rate; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg02018176 chr4:1364513 KIAA1530 0.53 9.24 0.45 2.99e-18 Obesity-related traits; LUSC cis rs7827545 0.545 rs6578228 chr8:135562422 G/A cg17885191 chr8:135476712 NA 0.61 7.79 0.39 8.69e-14 Hypertension (SNP x SNP interaction); LUSC cis rs2074585 0.708 rs2589939 chr15:90930875 C/T cg10434728 chr15:90938212 IQGAP1 0.43 8.78 0.43 8.7e-17 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs711244 0.783 rs2252032 chr2:37099339 C/T cg14987922 chr2:37194071 STRN 0.46 6.65 0.34 1.18e-10 Mean platelet volume; LUSC trans rs10877945 0.522 rs7297754 chr12:63443521 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -0.43 -6.99 -0.36 1.55e-11 Obesity-related traits; LUSC cis rs17155006 0.664 rs1735499 chr7:107738882 G/A cg05962710 chr7:107745446 LAMB4 -0.36 -6.3 -0.33 9.63e-10 Pneumococcal bacteremia; LUSC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg01652190 chr22:50026171 C22orf34 -0.3 -6.2 -0.32 1.71e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2594714 0.515 rs10411270 chr19:13940838 A/T cg18576835 chr19:13944261 NA -0.46 -7.21 -0.37 3.7e-12 Breast cancer; LUSC cis rs7917772 0.582 rs10786680 chr10:104317192 A/G cg05855489 chr10:104503620 C10orf26 -0.51 -7.68 -0.39 1.82e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg05872129 chr22:39784769 NA -0.61 -11.46 -0.53 7.48e-26 Intelligence (multi-trait analysis); LUSC cis rs76793172 1.000 rs7257342 chr19:46356418 C/T cg00442267 chr19:46317840 RSPH6A -0.5 -5.69 -0.3 2.77e-8 Eosinophil counts; LUSC cis rs12618769 0.597 rs1587835 chr2:99041269 A/C cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC trans rs7567288 0.636 rs7574116 chr2:134466301 T/C cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.06 -0.31 3.67e-9 Alzheimer's disease (late onset); LUSC cis rs6500602 0.634 rs2270365 chr16:4526758 G/A cg08645402 chr16:4508243 NA 0.52 8.86 0.44 4.72e-17 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08991391 chr14:60716504 PPM1A -0.4 -5.98 -0.31 5.61e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07491203 chr7:155089714 INSIG1 -0.38 -6.23 -0.32 1.43e-9 Electrocardiographic conduction measures; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg11060661 chr22:24314208 DDT;DDTL 0.5 8.07 0.4 1.27e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs208520 0.690 rs12208977 chr6:66725257 G/A cg07460842 chr6:66804631 NA 1.1 17.15 0.68 9.89e-48 Exhaled nitric oxide output; LUSC cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs6964587 1.000 rs13245393 chr7:91641928 A/G cg22117172 chr7:91764530 CYP51A1 0.31 5.7 0.3 2.7e-8 Breast cancer; LUSC trans rs1728785 1.000 rs8058145 chr16:68584090 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg00717180 chr2:96193071 NA -0.37 -5.98 -0.31 5.78e-9 HDL cholesterol; LUSC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg18876405 chr7:65276391 NA -0.77 -13.83 -0.6 1.06e-34 Aortic root size; LUSC cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg04586622 chr2:25135609 ADCY3 0.42 8.74 0.43 1.16e-16 Body mass index; LUSC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg07777115 chr5:623756 CEP72 -0.45 -5.77 -0.3 1.79e-8 Obesity-related traits; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg07507251 chr3:52567010 NT5DC2 0.37 7.49 0.38 6.36e-13 Electroencephalogram traits; LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg00106254 chr7:1943704 MAD1L1 -0.44 -6.34 -0.33 7.42e-10 Bipolar disorder and schizophrenia; LUSC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg27165867 chr14:105738592 BRF1 -0.51 -7.42 -0.38 9.52e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs6964587 1.000 rs416 chr7:91580571 A/G cg17063962 chr7:91808500 NA -0.58 -9.19 -0.45 4.34e-18 Breast cancer; LUSC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC cis rs34779708 0.897 rs4934527 chr10:35281118 T/A cg03585969 chr10:35415529 CREM 0.62 8.91 0.44 3.28e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10493773 0.510 rs11161645 chr1:86092872 T/C cg17807903 chr1:86174739 ZNHIT6 0.41 9.64 0.47 1.48e-19 Urate levels in overweight individuals; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg03068637 chr8:87521094 FAM82B 0.4 6.11 0.32 2.74e-9 Schizophrenia; LUSC cis rs807669 0.933 rs712959 chr22:19159015 C/T cg02655711 chr22:19163373 SLC25A1 0.78 15.3 0.64 1.97e-40 Metabolite levels; LUSC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg12615879 chr12:58013172 SLC26A10 -0.29 -5.94 -0.31 7.18e-9 Multiple sclerosis; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg02796970 chr10:39023768 NA -0.48 -7.82 -0.39 6.93e-14 Menopause (age at onset); LUSC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg12257692 chr3:49977190 RBM6 -0.25 -6.85 -0.35 3.54e-11 Body mass index; LUSC cis rs11971779 0.617 rs66652773 chr7:139109573 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs7927771 0.524 rs11039377 chr11:47789776 C/T cg20307385 chr11:47447363 PSMC3 0.44 6.47 0.33 3.4e-10 Subjective well-being; LUSC cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.23 0.37 3.33e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs2739330 0.760 rs5760095 chr22:24247293 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.63 -10.4 -0.49 3.93e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4969178 0.931 rs3826323 chr17:76400268 C/G cg05887092 chr17:76393375 PGS1 0.51 9.14 0.45 6.11e-18 HDL cholesterol levels; LUSC cis rs66887589 0.934 rs2389873 chr4:120554714 A/G cg24375607 chr4:120327624 NA -0.47 -7.24 -0.37 3.1e-12 Diastolic blood pressure; LUSC cis rs4588572 0.643 rs10043027 chr5:77792707 T/C cg11547950 chr5:77652471 NA -0.58 -8.21 -0.41 4.91e-15 Triglycerides; LUSC cis rs478304 0.654 rs7947604 chr11:65442059 G/C cg05805236 chr11:65401703 PCNXL3 -0.64 -10.47 -0.5 2.24e-22 Acne (severe); LUSC cis rs2242663 0.798 rs1791679 chr11:66337874 C/A cg24851651 chr11:66362959 CCS 0.37 5.9 0.31 8.71e-9 Bipolar disorder; LUSC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg05738196 chr6:26577821 NA 0.52 7.57 0.38 3.64e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg21862992 chr11:68658383 NA 0.49 7.83 0.39 6.45e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11650494 0.516 rs13341862 chr17:47494203 A/G cg08112188 chr17:47440006 ZNF652 -1.0 -8.2 -0.41 5.2e-15 Prostate cancer; LUSC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.18 -0.37 4.65e-12 Electroencephalogram traits; LUSC cis rs11716531 0.573 rs642570 chr3:27342595 C/G cg02860705 chr3:27208620 NA 0.47 8.55 0.42 4.33e-16 Diastolic blood pressure; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.07e-17 Prudent dietary pattern; LUSC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg18876405 chr7:65276391 NA 0.59 9.62 0.47 1.67e-19 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15531788 chr10:38146671 ZNF248 -0.51 -6.63 -0.34 1.36e-10 Bipolar disorder and schizophrenia; LUSC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg23649088 chr2:200775458 C2orf69 0.79 14.38 0.62 7.6e-37 Osteoporosis; LUSC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg13126279 chr21:47581558 C21orf56 -0.41 -5.8 -0.3 1.54e-8 Testicular germ cell tumor; LUSC cis rs7786877 0.626 rs11983745 chr7:100223678 T/C cg16850897 chr7:100343110 ZAN -0.47 -5.82 -0.3 1.37e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg01579765 chr21:45077557 HSF2BP -0.55 -11.44 -0.53 8.89e-26 Mean corpuscular volume; LUSC cis rs6964587 1.000 rs13231820 chr7:91663529 A/G cg22709100 chr7:91322751 NA 0.42 6.2 0.32 1.71e-9 Breast cancer; LUSC cis rs12310956 0.515 rs1405031 chr12:33958931 A/C cg06521331 chr12:34319734 NA -0.45 -7.3 -0.37 2.13e-12 Morning vs. evening chronotype; LUSC cis rs9747201 0.609 rs9303022 chr17:80170651 C/G cg18209359 chr17:80159595 CCDC57 -0.36 -5.83 -0.3 1.3e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg05347473 chr6:146136440 FBXO30 0.43 7.49 0.38 6.01e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9378688 1.000 rs3800187 chr6:2222253 C/T cg12303981 chr6:2244766 GMDS -0.49 -5.83 -0.3 1.31e-8 Caudate nucleus volume; LUSC cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg10172584 chr19:19639581 YJEFN3 -0.46 -5.74 -0.3 2.18e-8 Bipolar disorder; LUSC cis rs11997175 0.583 rs34540455 chr8:33799300 C/T ch.8.33884649F chr8:33765107 NA 0.49 7.31 0.37 1.97e-12 Body mass index; LUSC cis rs681343 1.000 rs681343 chr19:49206462 C/T cg21064579 chr19:49206444 FUT2 0.45 8.68 0.43 1.74e-16 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; LUSC cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs1322512 0.834 rs1744383 chr6:152941476 G/A cg27316956 chr6:152958899 SYNE1 -0.36 -5.9 -0.31 8.86e-9 Tonometry; LUSC cis rs1729407 0.565 rs2849173 chr11:116697321 G/C cg08985259 chr11:116699649 APOC3 -0.25 -5.67 -0.3 3.05e-8 Apolipoprotein A-IV levels; LUSC cis rs6500602 0.682 rs3761679 chr16:4457907 C/G cg08645402 chr16:4508243 NA 0.5 7.62 0.38 2.59e-13 Schizophrenia; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.01 0.77 5.62e-67 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg05368731 chr17:41323189 NBR1 0.92 16.04 0.66 2.4e-43 Menopause (age at onset); LUSC cis rs1691799 0.899 rs1168315 chr12:66746694 A/G cg16791601 chr12:66731901 HELB -0.71 -12.52 -0.57 9.7e-30 White blood cell count (basophil); LUSC cis rs7192380 0.756 rs12596945 chr16:69780819 C/A cg00738113 chr16:70207722 CLEC18C 0.28 5.75 0.3 2.02e-8 Sjögren's syndrome; LUSC cis rs4481887 0.646 rs28421649 chr1:248548122 G/C cg26353448 chr1:248524236 OR2T4 -0.3 -5.66 -0.3 3.24e-8 Common traits (Other); LUSC cis rs6598955 0.543 rs112752634 chr1:26534217 G/A cg04990556 chr1:26633338 UBXN11 0.85 11.14 0.52 9.76e-25 Obesity-related traits; LUSC cis rs6519955 0.897 rs4073601 chr22:46434686 A/G cg05468064 chr22:46423449 NA 0.37 6.45 0.33 4.03e-10 Dupuytren's disease; LUSC cis rs929354 0.713 rs3802130 chr7:156965237 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs6963495 0.818 rs73192144 chr7:105203535 C/T cg19920283 chr7:105172520 RINT1 0.57 5.89 0.31 9.54e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg02017074 chr12:117425053 FBXW8 0.62 7.19 0.37 4.24e-12 Subcortical brain region volumes;Hippocampal volume; LUSC cis rs116139393 1.000 rs116139393 chr7:6771660 C/G cg09896999 chr7:6746977 ZNF12 -0.5 -7.02 -0.36 1.22e-11 Alzheimer's disease (APOE e4 interaction); LUSC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg16049864 chr8:95962084 TP53INP1 -0.66 -12.19 -0.55 1.62e-28 Type 2 diabetes; LUSC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg18230493 chr5:56204884 C5orf35 -0.64 -9.81 -0.47 4.08e-20 Coronary artery disease; LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg19318889 chr4:1322082 MAEA 0.47 7.54 0.38 4.62e-13 Obesity-related traits; LUSC cis rs6700896 0.931 rs12043644 chr1:66147348 A/G cg04111102 chr1:66153794 NA 0.33 7.38 0.37 1.24e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs912057 0.582 rs1294412 chr6:6739854 A/G cg06612196 chr6:6737390 NA 0.63 13.14 0.58 4.4e-32 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs9682041 0.627 rs34392658 chr3:170091584 C/T cg11886554 chr3:170076028 SKIL 0.7 9.43 0.46 7.29e-19 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg05165339 chr4:1420672 NA 0.26 5.94 0.31 6.98e-9 Obesity-related traits; LUSC cis rs2050392 1.000 rs2050392 chr10:30691503 G/A cg18806716 chr10:30721971 MAP3K8 -0.45 -7.25 -0.37 2.84e-12 Inflammatory bowel disease; LUSC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg21724239 chr8:58056113 NA 0.78 9.45 0.46 6.03e-19 Developmental language disorder (linguistic errors); LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg09877947 chr5:131593287 PDLIM4 0.44 6.92 0.35 2.26e-11 Breast cancer; LUSC trans rs8072100 0.840 rs2136751 chr17:45456093 A/G cg03886242 chr7:26192032 NFE2L3 -0.4 -6.54 -0.34 2.31e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg01973587 chr1:228161476 NA 0.45 8.3 0.41 2.53e-15 Diastolic blood pressure; LUSC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg16414030 chr3:133502952 NA -0.42 -6.56 -0.34 2.11e-10 Iron status biomarkers; LUSC trans rs1486139 1.000 rs10267081 chr7:46296931 C/T cg17534202 chr9:96721102 NA -0.36 -6.41 -0.33 5.09e-10 Select biomarker traits; LUSC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg05861140 chr6:150128134 PCMT1 0.45 7.13 0.36 6.13e-12 Lung cancer; LUSC cis rs6681460 0.837 rs6669023 chr1:67171868 G/T cg02459107 chr1:67143332 SGIP1 0.45 8.3 0.41 2.57e-15 Presence of antiphospholipid antibodies; LUSC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg17507749 chr15:85114479 UBE2QP1 0.67 8.49 0.42 6.75e-16 Schizophrenia; LUSC cis rs34779708 0.931 rs12242882 chr10:35347860 G/C cg04310649 chr10:35416472 CREM -0.41 -6.43 -0.33 4.53e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 9.79 0.47 4.66e-20 Mean platelet volume; LUSC cis rs7119 0.717 rs12904254 chr15:77802585 C/A cg27398640 chr15:77910606 LINGO1 -0.3 -6.22 -0.32 1.47e-9 Type 2 diabetes; LUSC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg00944433 chr1:107599041 PRMT6 0.35 6.55 0.34 2.24e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg16049864 chr8:95962084 TP53INP1 -0.68 -13.49 -0.59 2.08e-33 Type 2 diabetes; LUSC trans rs61931739 0.534 rs73103090 chr12:34098801 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.58 0.42 3.73e-16 Morning vs. evening chronotype; LUSC cis rs10771431 0.597 rs10843144 chr12:9357577 C/T cg08997352 chr12:9597637 DDX12 -0.7 -11.05 -0.52 2.1e-24 Breast size; LUSC cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg23583168 chr7:148888333 NA -0.91 -17.54 -0.69 2.75e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4499344 0.604 rs259275 chr19:33159693 A/G cg22980127 chr19:33182716 NUDT19 -0.45 -6.66 -0.34 1.11e-10 Mean platelet volume; LUSC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg04800585 chr6:26043546 HIST1H2BB 0.39 5.87 0.31 1.08e-8 Intelligence (multi-trait analysis); LUSC cis rs4589502 0.925 rs4259997 chr15:67153310 A/G cg09911534 chr15:67153556 NA 0.49 6.48 0.33 3.3e-10 Lung cancer (smoking interaction); LUSC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg13206674 chr6:150067644 NUP43 0.5 7.53 0.38 4.76e-13 Lung cancer; LUSC cis rs7312933 0.618 rs7954523 chr12:42681508 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.51 7.15 0.36 5.44e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4516970 0.826 rs59246098 chr6:160149462 C/CA cg14767165 chr6:160183909 ACAT2 0.43 5.95 0.31 6.89e-9 Iron status biomarkers; LUSC cis rs66887589 0.837 rs7661498 chr4:120408108 T/C cg24375607 chr4:120327624 NA 0.5 7.77 0.39 9.66e-14 Diastolic blood pressure; LUSC cis rs308447 0.522 rs309363 chr4:123658169 C/G cg10495464 chr4:123653540 BBS12;LOC729338 0.83 11.53 0.53 3.9e-26 Perceived unattractiveness to mosquitoes; LUSC cis rs501916 0.605 rs8031169 chr15:48080330 G/C cg16110827 chr15:48056943 SEMA6D -0.37 -5.69 -0.3 2.75e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7246657 0.943 rs2291004 chr19:37997952 C/A cg23950597 chr19:37808831 NA -0.6 -7.26 -0.37 2.73e-12 Coronary artery calcification; LUSC cis rs782590 0.837 rs782584 chr2:55921116 C/G cg18811423 chr2:55921094 PNPT1 -0.89 -16.03 -0.66 2.76e-43 Metabolic syndrome; LUSC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg09359103 chr1:154839909 KCNN3 0.68 15.43 0.64 6.57e-41 Prostate cancer; LUSC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg13390004 chr1:15929781 NA 0.43 7.11 0.36 7.16e-12 Systolic blood pressure; LUSC cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg24450063 chr1:156163899 SLC25A44 1.18 29.13 0.85 1.04e-93 Testicular germ cell tumor; LUSC cis rs4692589 0.581 rs62344679 chr4:170963591 G/A cg19918862 chr4:170955249 NA 0.36 6.59 0.34 1.73e-10 Anxiety disorder; LUSC cis rs1044826 0.642 rs7624321 chr3:139220159 C/A cg00490450 chr3:139108681 COPB2 0.46 7.02 0.36 1.27e-11 Obesity-related traits; LUSC cis rs1997103 0.954 rs6593222 chr7:55372932 A/C cg17469321 chr7:55412551 NA 0.68 10.68 0.5 4.35e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9747201 1.000 rs12943668 chr17:80109930 C/T cg17462356 chr17:80056334 FASN 0.46 6.21 0.32 1.56e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3743162 1.000 rs12917429 chr15:85425097 A/C cg12863693 chr15:85201151 NMB -0.32 -5.91 -0.31 8.38e-9 Alzheimer's disease (age of onset); LUSC cis rs936229 0.861 rs7176022 chr15:75107880 G/T cg14664628 chr15:75095509 CSK 0.99 17.94 0.7 7.17e-51 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs4664308 1.000 rs4665147 chr2:160917062 A/G cg03641300 chr2:160917029 PLA2R1 -0.68 -11.31 -0.53 2.55e-25 Idiopathic membranous nephropathy; LUSC cis rs2953174 1.000 rs2975754 chr2:241522634 G/A cg07929629 chr2:241523174 NA 0.46 6.2 0.32 1.71e-9 Bipolar disorder; LUSC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg14500267 chr11:67383377 NA 0.32 6.1 0.32 3e-9 Mean corpuscular volume; LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg08736216 chr1:53307985 ZYG11A -0.29 -6.07 -0.32 3.51e-9 Monocyte count; LUSC cis rs17685 0.725 rs4728548 chr7:75654632 A/T cg16489192 chr7:75678113 MDH2;STYXL1 0.44 6.64 0.34 1.29e-10 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6542838 0.611 rs7423519 chr2:99518319 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.3 -0.33 9.4e-10 Fear of minor pain; LUSC trans rs1347297 0.614 rs4894017 chr2:179281062 C/T cg14011486 chr1:26737247 LIN28 0.46 7.14 0.36 5.96e-12 Alzheimer disease and age of onset; LUSC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg20891283 chr12:69753455 YEATS4 0.9 17.25 0.69 3.85e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.84 0.3 1.25e-8 Tonsillectomy; LUSC cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg06238570 chr21:40685208 BRWD1 0.49 7.6 0.38 2.98e-13 Menarche (age at onset); LUSC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs1005277 0.579 rs1740749 chr10:38521646 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.51 -0.46 3.89e-19 Extrinsic epigenetic age acceleration; LUSC trans rs12210905 0.688 rs72839471 chr6:27316959 C/T cg02699829 chr19:13216355 TRMT1 -0.56 -6.23 -0.32 1.39e-9 Hip circumference adjusted for BMI; LUSC trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg23505145 chr19:12996616 KLF1 0.65 11.05 0.52 2.17e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg18404041 chr3:52824283 ITIH1 0.6 10.3 0.49 8.46e-22 Schizophrenia; LUSC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg00071950 chr4:10020882 SLC2A9 0.6 9.79 0.47 4.48e-20 Bone mineral density; LUSC cis rs1577917 0.958 rs12190603 chr6:86475718 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.48 -0.42 7.54e-16 Response to antipsychotic treatment; LUSC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11718455 0.921 rs11130020 chr3:44009459 C/T cg08738300 chr3:44038990 NA 0.63 9.12 0.45 7.18e-18 Coronary artery disease; LUSC cis rs7208859 0.623 rs7212991 chr17:29143749 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9650315 0.810 rs13262665 chr8:57188282 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.41 0.33 4.87e-10 Height; LUSC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg16434002 chr17:42200994 HDAC5 -0.45 -6.35 -0.33 6.97e-10 Total body bone mineral density; LUSC cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg07870213 chr5:140052090 DND1 -0.75 -11.23 -0.52 4.69e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg03808351 chr9:123631620 PHF19 -0.48 -6.01 -0.31 4.96e-9 Birth weight; LUSC cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg18404041 chr3:52824283 ITIH1 0.4 6.94 0.35 2.07e-11 Body mass index; LUSC trans rs1994135 0.669 rs10844629 chr12:33697096 T/A cg26384229 chr12:38710491 ALG10B 0.62 8.6 0.43 3.05e-16 Resting heart rate; LUSC cis rs1728785 1.000 rs1624718 chr16:68580385 A/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg20135002 chr11:47629003 NA 0.48 7.55 0.38 4.28e-13 Subjective well-being; LUSC cis rs67366981 1.000 rs17105594 chr14:77713146 C/T cg22824376 chr14:77648248 TMEM63C 0.65 6.19 0.32 1.75e-9 Obsessive-compulsive symptoms; LUSC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.65 -0.39 2.15e-13 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs6740322 0.748 rs13420649 chr2:43463637 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -6.87 -0.35 3.21e-11 Coronary artery disease; LUSC cis rs8038465 0.615 rs8024862 chr15:73958290 C/T cg15420318 chr15:73925796 NPTN 0.62 10.72 0.51 3.11e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg09184832 chr6:79620586 NA -0.44 -6.91 -0.35 2.54e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs10782582 0.593 rs11576534 chr1:76112751 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.26 -0.37 2.71e-12 Daytime sleep phenotypes; LUSC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg05872129 chr22:39784769 NA 0.61 11.12 0.52 1.19e-24 Intelligence (multi-trait analysis); LUSC trans rs11039798 1.000 rs12223271 chr11:48417420 G/C cg15704280 chr7:45808275 SEPT13 0.67 6.31 0.33 8.99e-10 Axial length; LUSC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg16624210 chr5:671434 TPPP 0.49 6.04 0.31 4.06e-9 Lung disease severity in cystic fibrosis; LUSC cis rs1577917 0.740 rs2842604 chr6:86336300 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.86 -0.44 4.7e-17 Response to antipsychotic treatment; LUSC cis rs13315871 1.000 rs11706420 chr3:58392411 C/T cg12435725 chr3:58293450 RPP14 0.59 6.21 0.32 1.57e-9 Cholesterol, total; LUSC cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg14773178 chr5:1868261 NA 0.33 6.24 0.32 1.32e-9 Cardiovascular disease risk factors; LUSC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg03676636 chr4:99064102 C4orf37 0.37 7.65 0.39 2.14e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg16031515 chr1:205743344 RAB7L1 -0.28 -6.11 -0.32 2.73e-9 Menarche (age at onset); LUSC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -5.94 -0.31 7.15e-9 Subjective well-being; LUSC cis rs75920871 0.528 rs2513097 chr11:116836212 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.26 -0.32 1.16e-9 Subjective well-being; LUSC cis rs920590 0.527 rs79929516 chr8:19650050 G/C cg03894339 chr8:19674705 INTS10 0.8 9.9 0.48 1.92e-20 Acute lymphoblastic leukemia (childhood); LUSC cis rs9296092 0.517 rs78978280 chr6:33520747 T/A cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.77e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs35110281 0.811 rs7275705 chr21:45056453 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 12.4 0.56 2.75e-29 Mean corpuscular volume; LUSC cis rs3760982 1.000 rs11669175 chr19:44289824 A/G cg11993925 chr19:44307056 LYPD5 0.28 6.26 0.32 1.18e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs13385 0.769 rs13175916 chr5:139611508 T/C cg26211634 chr5:139558579 C5orf32 0.45 6.65 0.34 1.23e-10 Atrial fibrillation; LUSC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg11812906 chr14:75593930 NEK9 -0.63 -10.42 -0.5 3.34e-22 Height; LUSC cis rs7575217 0.767 rs13386749 chr2:101746592 C/T cg23907051 chr2:101730305 TBC1D8 -0.28 -7.39 -0.37 1.17e-12 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -9.27 -0.45 2.34e-18 Monocyte percentage of white cells; LUSC trans rs877282 0.947 rs12358875 chr10:757531 T/C cg22713356 chr15:30763199 NA 1.03 13.61 0.6 7.56e-34 Uric acid levels; LUSC cis rs977987 0.806 rs8050059 chr16:75388731 C/T cg04384234 chr16:75411784 CFDP1 -0.4 -6.33 -0.33 8.12e-10 Dupuytren's disease; LUSC trans rs804280 0.509 rs9886639 chr8:11784529 G/T cg27411982 chr8:10470053 RP1L1 0.4 6.14 0.32 2.3e-9 Myopia (pathological); LUSC cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg11764359 chr7:65958608 NA -0.59 -8.73 -0.43 1.27e-16 Aortic root size; LUSC cis rs6840360 1.000 rs6823421 chr4:152604719 T/C cg22705602 chr4:152727874 NA -0.28 -5.96 -0.31 6.43e-9 Intelligence (multi-trait analysis); LUSC cis rs17828380 1.000 rs71393136 chr15:63492776 C/G cg05507819 chr15:63340323 TPM1 -0.7 -5.92 -0.31 8.01e-9 Social communication problems; LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg04518342 chr5:131593106 PDLIM4 0.55 10.34 0.49 6.47e-22 Acylcarnitine levels; LUSC cis rs7804356 1.000 rs7785918 chr7:26861959 C/T cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg20887711 chr4:1340912 KIAA1530 0.42 6.52 0.34 2.67e-10 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12620342 chr12:56522011 ESYT1 0.45 6.79 0.35 5.08e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10028773 0.515 rs9994651 chr4:120587803 C/T cg09307838 chr4:120376055 NA 0.6 8.58 0.42 3.63e-16 Educational attainment; LUSC cis rs7937682 0.921 rs11213940 chr11:111433927 C/A cg09085632 chr11:111637200 PPP2R1B 0.95 13.24 0.59 1.82e-32 Primary sclerosing cholangitis; LUSC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg08736216 chr1:53307985 ZYG11A 0.3 6.07 0.32 3.55e-9 Monocyte count; LUSC cis rs7824557 0.564 rs2572386 chr8:11236975 A/G cg21775007 chr8:11205619 TDH -0.65 -10.15 -0.49 2.75e-21 Retinal vascular caliber; LUSC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg06453172 chr10:134556979 INPP5A -0.53 -6.47 -0.33 3.42e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2011503 0.882 rs10401714 chr19:19363630 G/A cg11584989 chr19:19387371 SF4 0.61 7.27 0.37 2.54e-12 Bipolar disorder; LUSC cis rs2120019 1.000 rs2415255 chr15:75332412 A/G cg09165964 chr15:75287851 SCAMP5 -1.15 -18.88 -0.72 1.33e-54 Blood trace element (Zn levels); LUSC cis rs4363385 0.510 rs6689510 chr1:153048039 G/A cg00922841 chr1:152955080 SPRR1A -0.38 -6.39 -0.33 5.43e-10 Inflammatory skin disease; LUSC cis rs9039 1.000 rs9039 chr16:9205363 A/G cg08831531 chr16:9218945 NA -0.67 -10.13 -0.48 3.4e-21 Menopause (age at onset); LUSC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg21770322 chr7:97807741 LMTK2 -0.41 -7.2 -0.37 4.05e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs6502050 0.835 rs6502068 chr17:80112223 C/T cg07393940 chr7:158741817 NA 0.36 6.52 0.34 2.66e-10 Life satisfaction; LUSC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg02569458 chr12:86230093 RASSF9 0.58 9.8 0.47 4.13e-20 Major depressive disorder; LUSC cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg03146154 chr1:46216737 IPP 0.57 8.47 0.42 7.65e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9300255 0.510 rs1790109 chr12:123637752 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.17 -0.32 1.95e-9 Neutrophil percentage of white cells; LUSC cis rs7597155 1.000 rs7597155 chr2:69985435 G/A cg02498382 chr2:70120550 SNRNP27 -0.24 -5.82 -0.3 1.37e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs76878669 0.561 rs10791876 chr11:66169646 C/T cg24851651 chr11:66362959 CCS 0.38 6.0 0.31 5.15e-9 Educational attainment (years of education); LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC cis rs3008870 1.000 rs2985817 chr1:67398607 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.15 0.64 7.62e-40 Lymphocyte percentage of white cells; LUSC cis rs6598163 0.520 rs12813376 chr12:132302324 C/T cg07389463 chr12:132296394 NA 0.43 8.03 0.4 1.73e-14 Migraine; LUSC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC cis rs7264396 0.887 rs2281849 chr20:34060286 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.15 -0.32 2.23e-9 Total cholesterol levels; LUSC trans rs8072100 0.840 rs1912482 chr17:45454883 G/A cg04995722 chr7:26192034 NFE2L3 -0.4 -6.56 -0.34 2.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9660992 0.710 rs4951184 chr1:205240659 A/T cg00857998 chr1:205179979 DSTYK 0.58 8.94 0.44 2.64e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs734999 0.588 rs10910098 chr1:2533250 C/A cg18854424 chr1:2615690 NA 0.49 9.91 0.48 1.84e-20 Ulcerative colitis; LUSC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.22 -0.37 3.46e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg24642439 chr20:33292090 TP53INP2 0.47 7.04 0.36 1.07e-11 Coronary artery disease; LUSC cis rs4819052 0.679 rs2236450 chr21:46702553 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.56 8.65 0.43 2.22e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.95 -12.69 -0.57 2.26e-30 Platelet count; LUSC trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg03929089 chr4:120376271 NA -0.45 -6.18 -0.32 1.92e-9 HDL cholesterol; LUSC trans rs1171606 0.731 rs1171648 chr10:61450932 C/T cg14119616 chr11:17099403 RPS13 -0.39 -5.96 -0.31 6.46e-9 Acylcarnitine levels; LUSC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12667521 chr19:29218732 NA 0.61 8.78 0.43 8.57e-17 Methadone dose in opioid dependence; LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg21782813 chr7:2030301 MAD1L1 0.58 10.31 0.49 8.12e-22 Bipolar disorder and schizophrenia; LUSC cis rs4343996 0.727 rs12537113 chr7:3370274 C/G cg21248987 chr7:3385318 SDK1 -0.35 -6.06 -0.31 3.62e-9 Motion sickness; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg02353165 chr6:42928485 GNMT 0.66 11.42 0.53 9.92e-26 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg23205692 chr1:25664452 TMEM50A -0.38 -5.69 -0.3 2.85e-8 Erythrocyte sedimentation rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11316592 chr17:63556608 AXIN2 0.43 6.36 0.33 6.74e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11644478 chr21:40555479 PSMG1 -0.73 -12.68 -0.57 2.43e-30 Cognitive function; LUSC cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.79 -0.35 5.04e-11 Monocyte percentage of white cells; LUSC cis rs11122272 0.735 rs2790880 chr1:231534259 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.81 -0.47 4.08e-20 Hemoglobin concentration; LUSC cis rs4786125 0.801 rs8057091 chr16:6902148 A/G cg03623568 chr16:6915990 A2BP1 -0.44 -7.78 -0.39 9.37e-14 Heart rate variability traits (SDNN); LUSC cis rs9549367 0.789 rs3861720 chr13:113906097 A/G cg00898013 chr13:113819073 PROZ -0.57 -8.13 -0.41 8.59e-15 Platelet distribution width; LUSC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg04034577 chr2:241836375 C2orf54 -0.49 -8.96 -0.44 2.3e-17 Urinary metabolites; LUSC cis rs2273669 0.667 rs76249006 chr6:109366740 G/A cg05315195 chr6:109294784 ARMC2 -0.52 -5.75 -0.3 2.07e-8 Prostate cancer; LUSC cis rs7639513 0.767 rs9861271 chr3:12707620 A/C cg23032965 chr3:12705835 RAF1 0.76 11.5 0.53 5.39e-26 Itch intensity from mosquito bite; LUSC cis rs2969070 1.000 rs1548594 chr7:2513281 G/C cg03277898 chr7:2518824 NA -0.26 -5.67 -0.3 3.17e-8 Diastolic blood pressure; LUSC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg03676636 chr4:99064102 C4orf37 0.34 7.44 0.38 8.44e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7223966 1.000 rs9909992 chr17:61731931 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.61 0.34 1.53e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 8.22 0.41 4.59e-15 Menarche (age at onset); LUSC cis rs9549260 0.755 rs9549255 chr13:41235213 C/T cg21288729 chr13:41239152 FOXO1 0.63 9.82 0.47 3.79e-20 Red blood cell count; LUSC cis rs2073300 1.000 rs79169006 chr20:23443535 A/T cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg02423579 chr7:2872169 GNA12 -0.38 -5.83 -0.3 1.31e-8 Height; LUSC cis rs12618769 0.625 rs56240302 chr2:99148970 C/T cg10123293 chr2:99228465 UNC50 0.47 7.76 0.39 1.04e-13 Bipolar disorder; LUSC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -12.08 -0.55 4.08e-28 Hemoglobin concentration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14298577 chr7:100272703 GNB2 -0.53 -6.55 -0.34 2.23e-10 Bipolar disorder and schizophrenia; LUSC cis rs7617480 0.544 rs6442129 chr3:48735256 T/C cg07636037 chr3:49044803 WDR6 0.77 10.09 0.48 4.54e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg14507445 chr22:49886340 NA -0.3 -5.82 -0.3 1.35e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10751667 0.961 rs6597954 chr11:987677 G/A ch.11.42038R chr11:967971 AP2A2 0.54 7.86 0.4 5.22e-14 Alzheimer's disease (late onset); LUSC cis rs763121 0.962 rs6001159 chr22:38966487 A/G cg06544989 chr22:39130855 UNC84B 0.35 6.14 0.32 2.36e-9 Menopause (age at onset); LUSC cis rs9283706 0.608 rs1428408 chr5:66331203 T/C cg11590213 chr5:66331682 MAST4 0.47 7.13 0.36 6.3e-12 Coronary artery disease; LUSC trans rs7937682 0.961 rs11828343 chr11:111491322 A/G cg18187862 chr3:45730750 SACM1L -0.51 -6.56 -0.34 2.09e-10 Primary sclerosing cholangitis; LUSC cis rs9369695 0.883 rs9381581 chr6:47580695 G/A cg12968598 chr6:47444699 CD2AP 0.53 8.1 0.41 1.06e-14 Reticulocyte count; LUSC cis rs10782582 0.609 rs5745325 chr1:76269460 G/A cg10523679 chr1:76189770 ACADM -0.48 -6.93 -0.35 2.15e-11 Daytime sleep phenotypes; LUSC cis rs11122272 0.735 rs2474631 chr1:231541341 T/A cg06096015 chr1:231504339 EGLN1 0.55 9.74 0.47 6.87e-20 Hemoglobin concentration; LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg01802117 chr1:53393560 SCP2 -0.39 -6.45 -0.33 3.94e-10 Monocyte count; LUSC cis rs7828089 0.582 rs7825938 chr8:22266866 G/A cg12081754 chr8:22256438 SLC39A14 0.78 12.45 0.56 1.66e-29 Verbal declarative memory; LUSC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg06544989 chr22:39130855 UNC84B 0.34 5.74 0.3 2.1e-8 Menopause (age at onset); LUSC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg08439880 chr3:133502540 NA -0.35 -6.23 -0.32 1.42e-9 Iron status biomarkers; LUSC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.57 -0.34 1.89e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6964587 1.000 rs6944591 chr7:91642714 T/C cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.71e-18 Breast cancer; LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg09021430 chr5:549028 NA -0.53 -7.47 -0.38 7.23e-13 Lung disease severity in cystic fibrosis; LUSC trans rs225245 0.791 rs6505492 chr17:34026597 C/T cg19694781 chr19:47549865 TMEM160 -0.4 -6.31 -0.33 8.84e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04867738 chr17:42298359 UBTF -0.53 -6.43 -0.33 4.51e-10 Bipolar disorder and schizophrenia; LUSC cis rs3859192 0.599 rs2270401 chr17:38176256 A/T cg17467752 chr17:38218738 THRA -0.51 -7.2 -0.37 4.05e-12 White blood cell count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08127293 chr16:14379328 NA -0.44 -6.5 -0.34 2.93e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7246657 0.943 rs10407084 chr19:37907792 T/C cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg21285383 chr16:89894308 SPIRE2 0.32 6.62 0.34 1.45e-10 Vitiligo; LUSC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.52 0.34 2.54e-10 Schizophrenia; LUSC cis rs9400467 0.509 rs463853 chr6:111673211 C/G cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg19622623 chr12:86230825 RASSF9 0.4 5.78 0.3 1.72e-8 Major depressive disorder; LUSC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg08470875 chr2:26401718 FAM59B -0.64 -8.73 -0.43 1.2e-16 Gut microbiome composition (summer); LUSC cis rs7592578 0.771 rs12052514 chr2:191378170 C/T cg10560079 chr2:191398806 TMEM194B -0.73 -9.11 -0.45 7.89e-18 Diastolic blood pressure; LUSC cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs847577 0.609 rs705308 chr7:97695363 C/A cg24562669 chr7:97807699 LMTK2 -0.48 -8.52 -0.42 5.53e-16 Breast cancer; LUSC cis rs7192380 0.928 rs12933210 chr16:69742048 A/T cg26679644 chr16:69762563 NA -0.36 -6.24 -0.32 1.3e-9 Sjögren's syndrome; LUSC cis rs7577696 0.785 rs12611678 chr2:32347785 G/A cg02381751 chr2:32503542 YIPF4 -0.44 -6.23 -0.32 1.4e-9 Inflammatory biomarkers; LUSC cis rs295140 0.967 rs4673906 chr2:201163812 G/T cg04283868 chr2:201171347 SPATS2L 0.43 6.52 0.34 2.67e-10 QT interval; LUSC cis rs611744 0.560 rs58605513 chr8:109279122 A/C cg18478394 chr8:109455254 TTC35 0.42 6.53 0.34 2.38e-10 Dupuytren's disease; LUSC cis rs9467711 0.606 rs9379871 chr6:26375854 C/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.17 -0.37 4.8e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs3008870 0.755 rs2065002 chr1:67487119 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.74 -11.88 -0.55 2.11e-27 Lymphocyte percentage of white cells; LUSC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg13683864 chr3:40499215 RPL14 0.95 17.12 0.68 1.34e-47 Renal cell carcinoma; LUSC cis rs929354 0.742 rs2051877 chr7:157008813 A/T cg05182265 chr7:156933206 UBE3C -0.6 -9.84 -0.47 3.03e-20 Body mass index; LUSC cis rs4148883 0.651 rs2851301 chr4:100010127 C/T cg12011299 chr4:100065546 ADH4 0.49 8.05 0.4 1.47e-14 Alcohol dependence; LUSC cis rs5769707 0.967 rs8141807 chr22:50043738 C/G cg07959070 chr22:50026188 C22orf34 -0.36 -7.36 -0.37 1.46e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7614311 0.731 rs6445387 chr3:63962678 C/G cg22134162 chr3:63841271 THOC7 -0.46 -5.82 -0.3 1.41e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs34779708 0.931 rs2490663 chr10:35329735 A/G cg04310649 chr10:35416472 CREM 0.4 6.14 0.32 2.33e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7618501 1.000 rs2271961 chr3:49878113 C/T cg24110177 chr3:50126178 RBM5 0.39 6.23 0.32 1.41e-9 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.59 -7.9 -0.4 4.16e-14 Renal function-related traits (BUN); LUSC cis rs12410462 0.681 rs79461024 chr1:227568783 G/T cg10327440 chr1:227177885 CDC42BPA -0.62 -5.79 -0.3 1.59e-8 Major depressive disorder; LUSC cis rs6547741 0.816 rs7560847 chr2:27882700 A/G cg12559939 chr2:27858050 GPN1 -0.4 -6.25 -0.32 1.29e-9 Oral cavity cancer; LUSC cis rs1107366 0.637 rs2044575 chr3:125976368 A/C cg01346077 chr3:125931526 NA 0.34 6.37 0.33 6.24e-10 Metabolite levels; LUSC cis rs7824557 0.628 rs11777746 chr8:11204755 T/C cg27411982 chr8:10470053 RP1L1 0.37 5.67 0.3 3.13e-8 Retinal vascular caliber; LUSC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg02487422 chr3:49467188 NICN1 0.46 7.39 0.37 1.22e-12 Resting heart rate; LUSC cis rs8072100 0.967 rs2317826 chr17:45730899 C/T cg25173405 chr17:45401733 C17orf57 -0.39 -6.22 -0.32 1.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.05e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.863 rs12498539 chr4:120468370 C/T cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.66e-25 Corneal astigmatism; LUSC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg10130564 chr11:117069849 TAGLN 0.37 6.41 0.33 4.88e-10 Blood protein levels; LUSC cis rs7246657 0.943 rs2891699 chr19:37920237 A/G cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs9549260 0.591 rs9577115 chr13:41276553 T/C cg21288729 chr13:41239152 FOXO1 0.54 8.28 0.41 3.09e-15 Red blood cell count; LUSC cis rs9815354 0.638 rs113496706 chr3:42028574 G/T cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs2732480 0.500 rs11168464 chr12:48602115 C/T cg04545296 chr12:48745243 ZNF641 0.33 6.17 0.32 2e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs926938 0.563 rs360655 chr1:115447867 T/C cg12756093 chr1:115239321 AMPD1 0.41 6.16 0.32 2.04e-9 Autism; LUSC cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg05283184 chr6:79620031 NA -0.57 -11.67 -0.54 1.22e-26 Intelligence (multi-trait analysis); LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg13685833 chr1:53393034 SCP2 0.44 6.53 0.34 2.49e-10 Monocyte count; LUSC trans rs7715474 0.707 rs1816980 chr5:120095414 C/A cg16756389 chr13:21834314 NA 0.36 6.06 0.31 3.61e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7020830 0.898 rs7038219 chr9:37182892 C/A cg14294708 chr9:37120828 ZCCHC7 1.02 22.38 0.77 2.1e-68 Schizophrenia; LUSC cis rs7789940 1.000 rs17149161 chr7:75978229 C/A cg10167463 chr7:75959203 YWHAG -0.66 -10.07 -0.48 5.33e-21 Multiple sclerosis; LUSC cis rs9393777 0.588 rs3799380 chr6:26467182 C/T cg12826209 chr6:26865740 GUSBL1 -0.68 -8.21 -0.41 4.83e-15 Intelligence (multi-trait analysis); LUSC cis rs7707921 0.690 rs6870335 chr5:81590070 A/T cg15871215 chr5:81402204 ATG10 -0.46 -7.18 -0.37 4.66e-12 Breast cancer; LUSC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 7.21 0.37 3.81e-12 Personality dimensions; LUSC cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg06636001 chr8:8085503 FLJ10661 0.53 7.88 0.4 4.76e-14 Mood instability; LUSC cis rs12421382 0.614 rs12418827 chr11:109390649 G/C cg11473876 chr11:109292803 C11orf87 0.34 5.74 0.3 2.15e-8 Schizophrenia; LUSC cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg13256891 chr4:100009986 ADH5 0.45 6.24 0.32 1.3e-9 Alcohol dependence; LUSC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg02487422 chr3:49467188 NICN1 0.4 5.67 0.3 3.15e-8 Parkinson's disease; LUSC cis rs8114671 0.967 rs6142324 chr20:33789043 C/T cg07148914 chr20:33460835 GGT7 -0.44 -6.55 -0.34 2.12e-10 Height; LUSC cis rs6545883 0.825 rs4672426 chr2:61457148 G/A cg15711740 chr2:61764176 XPO1 0.44 6.83 0.35 4.04e-11 Tuberculosis; LUSC cis rs778371 0.958 rs2675968 chr2:233736244 A/G cg08000102 chr2:233561755 GIGYF2 0.74 11.02 0.52 2.65e-24 Schizophrenia; LUSC cis rs679087 0.932 rs10843507 chr12:29931056 C/A cg14258853 chr12:29935411 TMTC1 0.85 14.64 0.63 7.49e-38 Schizophrenia; LUSC cis rs79349575 0.783 rs28409394 chr17:46998118 T/C cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC cis rs10880689 1 rs10880689 chr12:37930102 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.93e-21 Resting heart rate; LUSC cis rs738321 0.756 rs12167576 chr22:38512562 G/A cg25457927 chr22:38595422 NA -0.33 -6.16 -0.32 2.04e-9 Breast cancer; LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.42 0.75 1.05e-60 Prudent dietary pattern; LUSC cis rs1577917 1.000 rs2166663 chr6:86593896 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.17 -0.32 1.96e-9 Response to antipsychotic treatment; LUSC cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg02353165 chr6:42928485 GNMT 0.72 12.68 0.57 2.46e-30 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs45509595 0.841 rs2747054 chr6:27783359 A/G cg06606381 chr12:133084897 FBRSL1 -0.74 -7.4 -0.38 1.1e-12 Breast cancer; LUSC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg06238570 chr21:40685208 BRWD1 -0.63 -10.89 -0.51 8.06e-24 Cognitive function; LUSC cis rs113835537 0.660 rs7116940 chr11:66303895 T/C cg24851651 chr11:66362959 CCS 0.54 7.87 0.4 5.04e-14 Airway imaging phenotypes; LUSC cis rs1018836 0.923 rs2213886 chr8:91554163 G/C cg16814680 chr8:91681699 NA -0.77 -13.27 -0.59 1.4e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02475777 chr4:1388615 CRIPAK 0.62 9.24 0.45 3.02e-18 Longevity; LUSC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.47 -7.29 -0.37 2.27e-12 Alzheimer's disease (late onset); LUSC cis rs11677416 1.000 rs6542091 chr2:113525311 G/A cg27083787 chr2:113543245 IL1A 0.44 6.78 0.35 5.4e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs7799006 0.895 rs3757437 chr7:2271980 C/T cg12823233 chr7:2316876 SNX8 -0.37 -6.32 -0.33 8.36e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21942256 chr3:156892528 NA 0.48 7.5 0.38 5.99e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10761482 0.906 rs991405 chr10:62094202 C/T cg18175470 chr10:62150864 ANK3 0.49 7.13 0.36 6.24e-12 Schizophrenia; LUSC cis rs5758659 0.652 rs133323 chr22:42405922 T/C cg15557168 chr22:42548783 NA -0.33 -5.72 -0.3 2.43e-8 Cognitive function; LUSC cis rs909341 0.763 rs1291209 chr20:62330439 T/C cg09650180 chr20:62225654 GMEB2 -0.44 -5.79 -0.3 1.63e-8 Atopic dermatitis; LUSC cis rs861020 0.771 rs1962735 chr1:210012102 A/G cg05527609 chr1:210001259 C1orf107 0.89 13.17 0.58 3.37e-32 Orofacial clefts; LUSC cis rs968451 0.789 rs5757603 chr22:39677128 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.66 9.17 0.45 4.9e-18 Primary biliary cholangitis; LUSC cis rs738322 0.555 rs5750547 chr22:38546700 A/G cg25457927 chr22:38595422 NA 0.36 7.2 0.37 4.14e-12 Cutaneous nevi; LUSC cis rs7833787 1.000 rs7844500 chr8:18703343 A/G cg17701159 chr8:18705777 PSD3 -0.38 -6.17 -0.32 1.93e-9 Obesity-related traits; LUSC cis rs12760731 0.641 rs12036834 chr1:178236583 G/A cg00404053 chr1:178313656 RASAL2 0.63 6.65 0.34 1.19e-10 Obesity-related traits; LUSC cis rs7336332 0.598 rs7669 chr13:28009851 C/T cg22138327 chr13:27999177 GTF3A 0.87 9.66 0.47 1.2e-19 Weight; LUSC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg19230755 chr7:65878503 NA -0.43 -5.93 -0.31 7.67e-9 Aortic root size; LUSC cis rs9326248 0.559 rs1269329 chr11:116755041 T/C cg01368799 chr11:117014884 PAFAH1B2 0.58 8.71 0.43 1.48e-16 Blood protein levels; LUSC trans rs1005277 0.541 rs1740741 chr10:38515334 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.5 -0.46 4.09e-19 Extrinsic epigenetic age acceleration; LUSC cis rs3770081 1.000 rs60649958 chr2:86283000 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC cis rs9300255 0.602 rs1716172 chr12:123712712 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.22 -0.32 1.48e-9 Neutrophil percentage of white cells; LUSC cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.18 -0.41 6.18e-15 Axial length; LUSC cis rs16912285 0.892 rs80332091 chr11:24255248 T/A ch.11.24196551F chr11:24239977 NA 0.72 6.09 0.32 3.05e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs981844 1.000 rs2251997 chr4:154654067 A/G cg14289246 chr4:154710475 SFRP2 -0.48 -6.25 -0.32 1.22e-9 Response to statins (LDL cholesterol change); LUSC cis rs2072499 0.865 rs2758608 chr1:156202860 A/T cg25208724 chr1:156163844 SLC25A44 1.02 20.47 0.75 6.66e-61 Testicular germ cell tumor; LUSC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg14668632 chr7:2872130 GNA12 -0.49 -7.31 -0.37 2e-12 Height; LUSC cis rs75920871 0.528 rs4388921 chr11:116976778 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.46 -0.33 3.6e-10 Subjective well-being; LUSC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.26 -0.37 2.66e-12 Bipolar disorder; LUSC cis rs10392 0.543 rs3752290 chr20:37555116 G/C cg27552599 chr20:37590471 DHX35 0.45 7.37 0.37 1.31e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24377330 chr3:149375961 WWTR1 0.47 7.01 0.36 1.3e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9650315 0.866 rs3924847 chr8:57197009 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.56 7.13 0.36 6.25e-12 Height; LUSC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg13877915 chr19:58951672 ZNF132 -0.46 -7.49 -0.38 6.38e-13 Uric acid clearance; LUSC cis rs514406 0.536 rs878957 chr1:53197559 C/T cg25767906 chr1:53392781 SCP2 0.43 7.72 0.39 1.4e-13 Monocyte count; LUSC cis rs1348850 0.598 rs12616259 chr2:178503803 C/T cg22681709 chr2:178499509 PDE11A -0.6 -12.1 -0.55 3.39e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs6582630 0.537 rs1949611 chr12:38373092 C/T cg06521331 chr12:34319734 NA 0.38 6.11 0.32 2.77e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs968451 0.951 rs5750789 chr22:39725280 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.66 8.63 0.43 2.62e-16 Primary biliary cholangitis; LUSC cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs734999 0.505 rs4073286 chr1:2539901 A/C cg18854424 chr1:2615690 NA 0.52 10.81 0.51 1.52e-23 Ulcerative colitis; LUSC cis rs977987 0.806 rs11865004 chr16:75395777 C/T cg03315344 chr16:75512273 CHST6 0.48 9.2 0.45 4.05e-18 Dupuytren's disease; LUSC cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs73206853 0.841 rs73206847 chr12:110672353 G/A cg12870014 chr12:110450643 ANKRD13A 0.66 6.45 0.33 3.99e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs926938 0.584 rs6689326 chr1:115369112 T/A cg12756093 chr1:115239321 AMPD1 -0.53 -8.07 -0.4 1.31e-14 Autism; LUSC cis rs10045504 0.502 rs17456482 chr5:38737783 G/C cg15396434 chr5:38725168 NA -0.51 -5.65 -0.3 3.39e-8 Night sleep phenotypes; LUSC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg06481639 chr22:41940642 POLR3H 0.5 5.77 0.3 1.81e-8 Vitiligo; LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.11 -0.32 2.74e-9 Bipolar disorder and schizophrenia; LUSC cis rs7923609 1.000 rs10822161 chr10:65118203 G/A cg01631684 chr10:65280961 REEP3 -0.39 -6.11 -0.32 2.83e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.36 0.53 1.64e-25 Colorectal cancer; LUSC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg19920283 chr7:105172520 RINT1 0.58 6.21 0.32 1.61e-9 Bipolar disorder (body mass index interaction); LUSC cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 12.82 0.57 7.03e-31 Chronic sinus infection; LUSC cis rs929354 0.713 rs1034785 chr7:157002383 T/C cg17757837 chr7:157058334 UBE3C 0.83 13.22 0.59 2.23e-32 Body mass index; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg07677032 chr17:61819896 STRADA 0.53 8.99 0.44 1.89e-17 Prudent dietary pattern; LUSC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg10523679 chr1:76189770 ACADM 0.91 16.29 0.67 2.61e-44 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4805272 0.512 rs4805279 chr19:29336966 A/G cg12667521 chr19:29218732 NA 0.51 6.19 0.32 1.73e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.17e-10 Aortic root size; LUSC cis rs977987 0.806 rs12924920 chr16:75440133 G/A cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.8e-17 Dupuytren's disease; LUSC trans rs11764590 0.715 rs9639202 chr7:2087315 G/A cg10840412 chr1:235813424 GNG4 0.51 6.21 0.32 1.54e-9 Neuroticism; LUSC cis rs131777 0.545 rs131759 chr22:51015481 G/A cg00083937 chr22:51039805 MAPK8IP2 0.52 9.04 0.44 1.31e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.27 -0.32 1.09e-9 Crohn's disease; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.46 -0.42 8.53e-16 Menopause (age at onset); LUSC cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg05347473 chr6:146136440 FBXO30 0.54 9.16 0.45 5.44e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9323205 0.677 rs113612692 chr14:51709461 C/A cg23942311 chr14:51606299 NA -0.44 -8.41 -0.42 1.22e-15 Cancer; LUSC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg00750074 chr16:89608354 SPG7 -0.57 -10.34 -0.49 6.46e-22 Multiple myeloma (IgH translocation); LUSC cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg08999081 chr20:33150536 PIGU 0.39 7.07 0.36 8.94e-12 Height; LUSC cis rs7804356 1.000 rs3801814 chr7:26881302 T/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.58e-9 Type 1 diabetes; LUSC cis rs6424115 0.830 rs2502994 chr1:24199363 T/C cg15997130 chr1:24165203 NA 0.52 8.58 0.42 3.67e-16 Immature fraction of reticulocytes; LUSC cis rs10484885 0.878 rs72921937 chr6:90579863 T/G cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.31 -0.41 2.43e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg24881330 chr22:46731750 TRMU 0.81 6.7 0.34 8.97e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs9650315 0.929 rs7840181 chr8:57168032 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs11625487 0.957 rs10145540 chr14:77957354 C/T cg20045696 chr14:77926864 AHSA1 -0.48 -6.67 -0.34 1.04e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg08773314 chr2:239334832 ASB1 0.43 9.26 0.45 2.59e-18 Multiple system atrophy; LUSC cis rs6840360 0.571 rs6833814 chr4:152539679 A/G cg22705602 chr4:152727874 NA -0.32 -6.31 -0.33 8.76e-10 Intelligence (multi-trait analysis); LUSC cis rs2692947 0.644 rs2969491 chr2:96794982 C/T cg23100626 chr2:96804247 ASTL 0.3 7.17 0.37 4.93e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs789859 1.000 rs789862 chr3:194404522 C/T cg02072170 chr3:194406190 FAM43A -0.35 -7.53 -0.38 4.68e-13 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg04455712 chr21:45112962 RRP1B 0.45 8.24 0.41 4.1e-15 Mean corpuscular volume; LUSC cis rs12908161 1.000 rs35316992 chr15:85248133 A/G cg11189052 chr15:85197271 WDR73 0.49 5.98 0.31 5.78e-9 Schizophrenia; LUSC cis rs1691799 0.867 rs1168311 chr12:66725912 A/C cg16791601 chr12:66731901 HELB 0.69 12.12 0.55 2.86e-28 White blood cell count (basophil); LUSC cis rs1401999 0.650 rs3792585 chr3:183646222 A/G cg01324343 chr3:183735012 ABCC5 0.66 16.69 0.67 6.79e-46 Anterior chamber depth; LUSC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg22467129 chr15:76604101 ETFA -0.45 -7.03 -0.36 1.13e-11 Blood metabolite levels; LUSC cis rs1950626 0.833 rs1951025 chr14:101406022 T/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.42 7.46 0.38 7.73e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs554111 0.613 rs10753510 chr1:21412248 G/A cg01072550 chr1:21505969 NA 0.38 5.8 0.3 1.57e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg21951975 chr1:209979733 IRF6 0.55 6.88 0.35 2.95e-11 Cleft lip with or without cleft palate; LUSC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg05585544 chr11:47624801 NA -0.42 -7.26 -0.37 2.71e-12 Subjective well-being; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg00149659 chr3:10157352 C3orf10 0.92 11.72 0.54 8.44e-27 Alzheimer's disease; LUSC trans rs1994135 0.617 rs1384590 chr12:33734271 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.32 0.41 2.28e-15 Resting heart rate; LUSC cis rs950027 0.620 rs2453533 chr15:45641225 C/A cg04036182 chr15:45458818 NA 0.34 5.69 0.3 2.78e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs34734847 1.000 rs55730005 chr12:121157536 C/A cg21892295 chr12:121157589 UNC119B -0.52 -9.54 -0.46 3.07e-19 Mean corpuscular volume; LUSC trans rs11098499 0.820 rs6534140 chr4:120455311 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs11098499 0.874 rs13139045 chr4:120168588 T/C cg24375607 chr4:120327624 NA 0.67 10.33 0.49 7e-22 Corneal astigmatism; LUSC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg21724239 chr8:58056113 NA 0.56 6.52 0.34 2.52e-10 Developmental language disorder (linguistic errors); LUSC cis rs1044826 1.000 rs9289577 chr3:139200327 C/G cg00490450 chr3:139108681 COPB2 0.51 6.74 0.35 6.96e-11 Obesity-related traits; LUSC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg26335602 chr6:28129616 ZNF389 0.46 6.5 0.34 2.9e-10 Parkinson's disease; LUSC cis rs6076065 0.962 rs2424529 chr20:23369317 A/G cg11657817 chr20:23433608 CST11 0.43 8.68 0.43 1.79e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg17279839 chr7:150038598 RARRES2 0.55 8.18 0.41 6.01e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs9303401 0.614 rs2007993 chr17:56590643 T/C cg25039879 chr17:56429692 SUPT4H1 0.71 9.47 0.46 5.43e-19 Cognitive test performance; LUSC cis rs12421382 0.659 rs35093943 chr11:109379872 C/A cg27471124 chr11:109292789 C11orf87 0.41 7.09 0.36 8.05e-12 Schizophrenia; LUSC cis rs701145 0.585 rs1527799 chr3:153811226 A/G cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs1670533 0.932 rs4690214 chr4:1054636 T/C cg02018176 chr4:1364513 KIAA1530 0.44 6.11 0.32 2.78e-9 Recombination rate (females); LUSC cis rs2404602 0.647 rs12440511 chr15:76993135 A/G cg23625390 chr15:77176239 SCAPER -0.65 -9.66 -0.47 1.29e-19 Blood metabolite levels; LUSC cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg03264133 chr6:25882463 NA -0.34 -5.69 -0.3 2.8e-8 Height; LUSC trans rs9329221 0.623 rs7825778 chr8:10261010 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.66 -0.34 1.13e-10 Neuroticism; LUSC cis rs77633900 0.772 rs284897 chr15:76750722 T/C cg21673338 chr15:77095150 SCAPER -0.7 -6.1 -0.32 2.9e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.83 -0.57 6.66e-31 Chronic sinus infection; LUSC cis rs3796619 1.000 rs11247973 chr4:1094314 G/A cg27284194 chr4:1044797 NA 0.48 7.65 0.39 2.21e-13 Recombination rate (males); LUSC cis rs2070488 0.775 rs6794397 chr3:38559307 A/G cg24069376 chr3:38537580 EXOG 0.41 8.01 0.4 1.95e-14 Electrocardiographic conduction measures; LUSC cis rs748404 0.697 rs513970 chr15:43579566 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.43 6.02 0.31 4.66e-9 Lung cancer; LUSC cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.73 12.43 0.56 2.1e-29 Personality dimensions; LUSC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.28e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg03354898 chr7:1950403 MAD1L1 -0.34 -6.4 -0.33 5.3e-10 Bipolar disorder and schizophrenia; LUSC trans rs2243480 1.000 rs2420170 chr7:65656053 T/C cg10756647 chr7:56101905 PSPH -0.87 -8.68 -0.43 1.74e-16 Diabetic kidney disease; LUSC cis rs9359856 0.636 rs6454767 chr6:90317335 G/A cg13799429 chr6:90582589 CASP8AP2 0.76 8.14 0.41 8.07e-15 Bipolar disorder; LUSC cis rs7100689 0.646 rs1890889 chr10:82090827 G/T cg01528321 chr10:82214614 TSPAN14 0.78 11.84 0.54 2.94e-27 Post bronchodilator FEV1; LUSC cis rs7296418 0.961 rs1790122 chr12:123606739 G/A cg06742321 chr12:123595122 PITPNM2 0.39 5.74 0.3 2.17e-8 Platelet count; LUSC cis rs56283067 0.578 rs1321078 chr6:45368214 G/T cg18551225 chr6:44695536 NA -0.43 -6.41 -0.33 4.92e-10 Total body bone mineral density; LUSC cis rs4363385 0.747 rs2225919 chr1:152969603 A/G cg00922841 chr1:152955080 SPRR1A -0.43 -7.59 -0.38 3.32e-13 Inflammatory skin disease; LUSC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg12311346 chr5:56204834 C5orf35 -0.89 -12.81 -0.57 7.52e-31 Initial pursuit acceleration; LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9287719 0.967 rs728281 chr2:10750355 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs9486719 0.895 rs12195315 chr6:96905711 T/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.78 -0.47 4.81e-20 Migraine;Coronary artery disease; LUSC trans rs7681440 0.904 rs7671549 chr4:90771147 T/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.97 -0.31 6.18e-9 Dementia with Lewy bodies; LUSC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg23758822 chr17:41437982 NA 1.04 20.17 0.74 1.03e-59 Menopause (age at onset); LUSC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg10523679 chr1:76189770 ACADM 0.88 15.53 0.65 2.59e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12410462 0.681 rs114950580 chr1:227673334 G/C cg04117972 chr1:227635322 NA 0.76 7.27 0.37 2.65e-12 Major depressive disorder; LUSC trans rs12210905 1.000 rs72843629 chr6:27175215 G/T cg11837749 chr1:55047332 ACOT11 0.57 6.08 0.32 3.31e-9 Hip circumference adjusted for BMI; LUSC trans rs61931739 0.553 rs68124042 chr12:34064431 C/A cg13010199 chr12:38710504 ALG10B 0.56 8.56 0.42 4.16e-16 Morning vs. evening chronotype; LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.69 -0.57 2.24e-30 Platelet count; LUSC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -14.21 -0.61 3.52e-36 Hemoglobin concentration; LUSC cis rs68170813 0.559 rs79564258 chr7:107059803 C/A cg02696742 chr7:106810147 HBP1 -0.64 -9.11 -0.45 8.03e-18 Coronary artery disease; LUSC cis rs9359856 0.913 rs9362663 chr6:90307550 A/C cg13799429 chr6:90582589 CASP8AP2 0.55 6.41 0.33 4.94e-10 Bipolar disorder; LUSC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg01802117 chr1:53393560 SCP2 0.38 6.18 0.32 1.82e-9 Monocyte count; LUSC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg15105969 chr2:36825350 FEZ2 0.58 8.72 0.43 1.33e-16 Height; LUSC cis rs9807841 0.568 rs3859514 chr19:10748820 T/C cg17710535 chr19:10819994 QTRT1 0.4 6.59 0.34 1.69e-10 Inflammatory skin disease; LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs752010 0.871 rs2038976 chr1:42094498 A/G cg06885757 chr1:42089581 HIVEP3 0.5 10.17 0.49 2.41e-21 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs861020 1.000 rs622832 chr1:209974232 A/C cg05527609 chr1:210001259 C1orf107 0.9 11.74 0.54 6.9e-27 Orofacial clefts; LUSC cis rs9303401 0.659 rs62083436 chr17:57031742 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.77 0.57 1.09e-30 Cognitive test performance; LUSC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.09 0.52 1.58e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.954 rs7436506 chr4:120393769 T/C cg24375607 chr4:120327624 NA 0.81 12.0 0.55 8.02e-28 Corneal astigmatism; LUSC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg14895029 chr7:2775587 GNA12 -0.37 -5.91 -0.31 8.27e-9 Height; LUSC cis rs3784262 1.000 rs7165247 chr15:58251786 C/T cg12031962 chr15:58353849 ALDH1A2 0.33 6.15 0.32 2.16e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs72781680 0.716 rs7564732 chr2:24034178 C/T cg08917208 chr2:24149416 ATAD2B 0.59 6.78 0.35 5.32e-11 Lymphocyte counts; LUSC cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg06671706 chr8:8559999 CLDN23 0.48 6.58 0.34 1.84e-10 Obesity-related traits; LUSC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.94 0.36 2.04e-11 Tonsillectomy; LUSC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.33e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4240897 0.935 rs1474868 chr1:12044164 A/G cg13216073 chr1:12042593 MFN2 -0.38 -6.67 -0.34 1.05e-10 Tuberculosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07458712 chr4:1769731 NA 0.48 7.21 0.37 3.8e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2262909 0.924 rs11085509 chr19:22204573 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -6.2 -0.32 1.68e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs478607 0.915 rs521793 chr11:64482947 G/C cg19131476 chr11:64387923 NRXN2 -0.31 -5.68 -0.3 2.9e-8 Urate levels; LUSC cis rs4969178 0.965 rs11077364 chr17:76400337 C/A cg05887092 chr17:76393375 PGS1 0.51 9.05 0.44 1.2e-17 HDL cholesterol levels; LUSC cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10635789 chr4:668276 ATP5I -0.4 -6.03 -0.31 4.36e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4853525 0.859 rs1894775 chr2:191716706 T/C cg11845111 chr2:191398756 TMEM194B -0.42 -6.18 -0.32 1.91e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs7903847 0.642 rs3814553 chr10:99155984 G/A cg08345082 chr10:99160200 RRP12 -0.35 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs4919087 0.923 rs12357266 chr10:98978045 G/A cg25902810 chr10:99078978 FRAT1 0.51 7.28 0.37 2.48e-12 Monocyte count; LUSC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg03526776 chr6:41159608 TREML2 0.33 6.19 0.32 1.74e-9 Alzheimer's disease (late onset); LUSC cis rs4595586 0.525 rs35089392 chr12:39414547 T/G cg13010199 chr12:38710504 ALG10B 0.45 6.4 0.33 5.12e-10 Morning vs. evening chronotype; LUSC cis rs7927771 0.524 rs11039329 chr11:47684908 A/G cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.16e-10 Subjective well-being; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg20295408 chr7:1910781 MAD1L1 -0.47 -6.74 -0.35 6.76e-11 Bipolar disorder and schizophrenia; LUSC cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg11019008 chr10:131425282 MGMT 0.4 5.79 0.3 1.66e-8 Response to temozolomide; LUSC trans rs6502050 0.805 rs4789720 chr17:80157490 G/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.81e-10 Life satisfaction; LUSC cis rs1359582 0.736 rs1980813 chr10:90354888 A/T cg15661332 chr10:90342814 RNLS -0.47 -5.78 -0.3 1.75e-8 Depressive and manic episodes in bipolar disorder; LUSC cis rs7808935 0.628 rs72598552 chr7:27939961 G/A cg22168087 chr7:27702803 HIBADH 0.7 8.29 0.41 2.84e-15 Prostate cancer; LUSC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg08470875 chr2:26401718 FAM59B -0.69 -9.18 -0.45 4.5e-18 Gut microbiome composition (summer); LUSC cis rs1577917 0.771 rs2842608 chr6:86295858 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.54 -8.59 -0.43 3.31e-16 Response to antipsychotic treatment; LUSC cis rs2932538 0.883 rs6696991 chr1:113095661 C/T cg22162597 chr1:113214053 CAPZA1 0.55 7.89 0.4 4.48e-14 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg26695010 chr11:65641043 EFEMP2 -0.46 -7.0 -0.36 1.37e-11 Eosinophil percentage of white cells; LUSC cis rs7577696 0.539 rs13010405 chr2:32338204 A/T cg02381751 chr2:32503542 YIPF4 -0.5 -6.73 -0.35 7.48e-11 Inflammatory biomarkers; LUSC trans rs2392780 0.536 rs430693 chr8:128338594 G/T cg10897648 chr18:56338258 MALT1 -0.42 -6.35 -0.33 6.95e-10 Breast cancer (early onset); LUSC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 8.16 0.41 7.05e-15 Bipolar disorder; LUSC cis rs12421382 0.507 rs10890995 chr11:109327622 A/G cg16359550 chr11:109292809 C11orf87 -0.48 -8.27 -0.41 3.26e-15 Schizophrenia; LUSC cis rs16895831 0.519 rs16895863 chr6:42571346 A/T cg10605015 chr6:42532144 UBR2 -0.47 -5.8 -0.3 1.56e-8 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells;Eosinophil percentage of white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Neutrophil count;Sum basophil neutrophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg11645453 chr3:52864694 ITIH4 -0.56 -13.23 -0.59 2.09e-32 Schizophrenia; LUSC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg12311346 chr5:56204834 C5orf35 -0.92 -13.6 -0.6 7.64e-34 Initial pursuit acceleration; LUSC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg20307385 chr11:47447363 PSMC3 -0.44 -5.82 -0.3 1.36e-8 Subjective well-being; LUSC cis rs854765 0.693 rs11657074 chr17:17770355 G/A cg09796270 chr17:17721594 SREBF1 -0.43 -7.64 -0.39 2.25e-13 Total body bone mineral density; LUSC cis rs7119167 0.851 rs3741148 chr11:73114723 A/G cg17517138 chr11:73019481 ARHGEF17 0.53 6.19 0.32 1.81e-9 Blood protein levels; LUSC trans rs41433250 1 rs41433250 chr13:31495835 A/G cg06944693 chr11:130299298 ADAMTS8 -0.57 -6.21 -0.32 1.54e-9 Influenza A (H1N1) infection;Mild influenza (H1N1) infection; LUSC trans rs10802346 0.545 rs2362253 chr1:246371676 G/A cg22732515 chr19:44031385 ETHE1 0.62 10.32 0.49 7.17e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg02569458 chr12:86230093 RASSF9 0.52 8.57 0.42 3.81e-16 Major depressive disorder; LUSC cis rs4285028 0.747 rs58367397 chr3:121451700 A/G cg11130432 chr3:121712080 ILDR1 -0.53 -7.76 -0.39 1.02e-13 Multiple sclerosis; LUSC cis rs870825 0.616 rs57316663 chr4:185630011 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.05 0.58 9.8e-32 Blood protein levels; LUSC cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg08213375 chr14:104286397 PPP1R13B -0.46 -8.31 -0.41 2.51e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs4718428 0.705 rs4718424 chr7:66376095 G/A cg18876405 chr7:65276391 NA 0.49 6.68 0.34 9.84e-11 Corneal structure; LUSC cis rs2455601 0.671 rs10840135 chr11:8879794 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -7.41 -0.38 1.06e-12 Schizophrenia; LUSC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg18306943 chr3:40428807 ENTPD3 0.36 5.82 0.3 1.42e-8 Renal cell carcinoma; LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg02951883 chr7:2050386 MAD1L1 -0.39 -6.65 -0.34 1.21e-10 Bipolar disorder and schizophrenia; LUSC cis rs950169 0.887 rs71395453 chr15:85113490 G/C cg12863693 chr15:85201151 NMB 0.34 6.81 0.35 4.58e-11 Schizophrenia; LUSC cis rs6733011 0.578 rs12468024 chr2:99495980 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.79 -0.3 1.67e-8 Bipolar disorder; LUSC cis rs1729951 0.575 rs361248 chr3:136709066 G/A cg21827317 chr3:136751795 NA 0.39 7.09 0.36 8.25e-12 Neuroticism; LUSC cis rs9372498 0.536 rs62422236 chr6:118972633 G/T cg18833306 chr6:118973337 C6orf204 -0.46 -5.85 -0.3 1.2e-8 Diastolic blood pressure; LUSC cis rs9549367 0.789 rs2302757 chr13:113909339 A/G cg00898013 chr13:113819073 PROZ -0.56 -8.11 -0.41 1.01e-14 Platelet distribution width; LUSC cis rs12530845 1.000 rs60179239 chr7:135333028 A/G cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg27532560 chr4:187881888 NA -0.43 -7.05 -0.36 1.05e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9902453 0.904 rs55633288 chr17:28368196 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.53 -0.5 1.46e-22 Coffee consumption (cups per day); LUSC cis rs7212590 0.748 rs73315252 chr17:57854855 A/G cg10252138 chr17:58120427 NA -0.73 -6.91 -0.35 2.44e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 14.52 0.62 2.32e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs62400317 0.859 rs56337964 chr6:45039786 G/A cg20913747 chr6:44695427 NA -0.46 -7.43 -0.38 9.41e-13 Total body bone mineral density; LUSC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg08847533 chr14:75593920 NEK9 0.85 16.03 0.66 2.81e-43 Height; LUSC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg23262073 chr20:60523788 NA -0.39 -6.11 -0.32 2.72e-9 Body mass index; LUSC cis rs1062746 0.771 rs10514621 chr16:87369578 G/T cg02258303 chr16:87377426 FBXO31 -0.55 -9.44 -0.46 6.81e-19 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs4764124 0.646 rs10744078 chr12:14978535 T/G cg19759883 chr12:14956454 WBP11;C12orf60 -0.37 -5.73 -0.3 2.3e-8 Pubertal anthropometrics; LUSC cis rs9549260 0.564 rs9646110 chr13:41308301 A/T cg21288729 chr13:41239152 FOXO1 -0.52 -7.88 -0.4 4.77e-14 Red blood cell count; LUSC cis rs4363385 1.000 rs4363385 chr1:152989321 A/G cg00922841 chr1:152955080 SPRR1A -0.47 -7.88 -0.4 4.64e-14 Inflammatory skin disease; LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs6952808 0.862 rs4721167 chr7:1933224 C/T cg04565464 chr8:145669602 NFKBIL2 0.37 6.14 0.32 2.38e-9 Bipolar disorder and schizophrenia; LUSC trans rs72674100 0.867 rs7656650 chr4:97964570 A/G cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg11247378 chr22:39784982 NA 0.57 9.97 0.48 1.19e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs28595532 0.920 rs17258830 chr4:119725543 A/T cg02775129 chr4:119771670 NA 0.93 7.34 0.37 1.66e-12 Cannabis dependence symptom count; LUSC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg16680214 chr1:154839983 KCNN3 0.41 7.14 0.36 5.99e-12 Prostate cancer; LUSC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg06108461 chr20:60628389 TAF4 -0.72 -11.61 -0.54 2.12e-26 Body mass index; LUSC cis rs8070128 0.534 rs2955350 chr17:17953548 G/A cg04398451 chr17:18023971 MYO15A 0.57 9.53 0.46 3.41e-19 Total body bone mineral density; LUSC trans rs7824557 0.767 rs2060463 chr8:11161610 T/G cg15556689 chr8:8085844 FLJ10661 0.55 8.46 0.42 8.4e-16 Retinal vascular caliber; LUSC cis rs1994135 0.715 rs11052742 chr12:33692290 A/C cg06521331 chr12:34319734 NA -0.39 -5.81 -0.3 1.43e-8 Resting heart rate; LUSC cis rs11105298 0.891 rs10858865 chr12:89846476 G/A cg00757033 chr12:89920650 WDR51B 0.59 10.19 0.49 2.14e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8028313 0.731 rs4776964 chr15:68016955 T/G cg24579218 chr15:68104479 NA -0.38 -6.59 -0.34 1.69e-10 Obesity; LUSC cis rs4845459 0.967 rs4845452 chr1:152591647 A/G cg08895932 chr1:152778580 LCE1C -0.37 -6.39 -0.33 5.71e-10 Psoriasis; LUSC cis rs9653442 0.564 rs12712071 chr2:100793876 G/A cg22139774 chr2:100720529 AFF3 -0.42 -7.28 -0.37 2.47e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC trans rs61931739 0.500 rs11053189 chr12:34433455 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.77 0.51 2.01e-23 Morning vs. evening chronotype; LUSC cis rs6725041 0.547 rs61696052 chr2:213201295 G/C cg16329650 chr2:213403929 ERBB4 -0.42 -6.67 -0.34 1.06e-10 QT interval (ambient particulate matter interaction); LUSC cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg07148914 chr20:33460835 GGT7 0.54 8.21 0.41 4.99e-15 Height; LUSC cis rs11098499 0.619 rs28502463 chr4:120257023 T/C cg24375607 chr4:120327624 NA 0.77 12.51 0.56 1.08e-29 Corneal astigmatism; LUSC cis rs1538970 1.000 rs1538970 chr1:45847562 G/A cg06784218 chr1:46089804 CCDC17 0.34 6.08 0.32 3.27e-9 Platelet count; LUSC cis rs73416724 1.000 rs17209400 chr6:43328062 A/G cg26312998 chr6:43337775 ZNF318 0.57 6.66 0.34 1.16e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.29e-31 Prudent dietary pattern; LUSC cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.78 -0.51 1.83e-23 Chronic sinus infection; LUSC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg12257692 chr3:49977190 RBM6 -0.25 -6.87 -0.35 3.08e-11 Body mass index; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg01238044 chr22:24384105 GSTT1 -0.52 -7.59 -0.38 3.15e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs3744061 0.520 rs4322697 chr17:74648642 C/T cg27546012 chr17:74684504 MXRA7 -0.38 -6.73 -0.35 7.23e-11 Retinal arteriolar caliber; LUSC cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg07520158 chr7:32535189 LSM5;AVL9 -0.54 -7.69 -0.39 1.71e-13 Cognitive ability; LUSC cis rs1865760 0.929 rs9467646 chr6:25957408 A/G cg17691542 chr6:26056736 HIST1H1C 0.44 6.46 0.33 3.75e-10 Height; LUSC cis rs11250098 0.642 rs4841460 chr8:10789493 C/G cg21775007 chr8:11205619 TDH -0.49 -6.65 -0.34 1.22e-10 Morning vs. evening chronotype; LUSC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg08847533 chr14:75593920 NEK9 0.84 15.6 0.65 1.29e-41 Height; LUSC cis rs977987 0.815 rs1364078 chr16:75396881 T/C cg03315344 chr16:75512273 CHST6 0.53 10.37 0.49 5.15e-22 Dupuytren's disease; LUSC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6906287 0.647 rs7746778 chr6:118725871 C/A cg21191810 chr6:118973309 C6orf204 0.33 6.05 0.31 3.93e-9 Electrocardiographic conduction measures; LUSC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg16049864 chr8:95962084 TP53INP1 0.5 9.15 0.45 5.59e-18 Type 2 diabetes; LUSC cis rs2486288 0.656 rs6493144 chr15:45573489 C/G cg04036182 chr15:45458818 NA 0.36 5.89 0.31 9.21e-9 Glomerular filtration rate; LUSC cis rs7246657 0.678 rs2927740 chr19:38140966 A/G cg23950597 chr19:37808831 NA 0.49 5.81 0.3 1.47e-8 Coronary artery calcification; LUSC cis rs1044826 0.642 rs186103 chr3:139211942 C/A cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.82e-11 Obesity-related traits; LUSC cis rs1448094 0.933 rs11117102 chr12:86312720 A/C cg02569458 chr12:86230093 RASSF9 0.43 6.72 0.34 8e-11 Major depressive disorder; LUSC cis rs67311347 0.713 rs73073505 chr3:40310693 C/T cg13683864 chr3:40499215 RPL14 -0.98 -16.53 -0.67 2.78e-45 Renal cell carcinoma; LUSC cis rs9653442 0.593 rs7597861 chr2:100853187 G/A cg07810366 chr2:100720526 AFF3 -0.39 -6.37 -0.33 6.41e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg14440974 chr22:39074834 NA -0.36 -5.98 -0.31 5.74e-9 Menopause (age at onset); LUSC cis rs910316 0.836 rs6574212 chr14:75671659 G/A cg11812906 chr14:75593930 NEK9 -0.58 -9.54 -0.46 3.13e-19 Height; LUSC cis rs11098499 0.954 rs17046116 chr4:120387259 G/A cg09307838 chr4:120376055 NA 0.78 11.26 0.52 3.88e-25 Corneal astigmatism; LUSC trans rs617791 0.508 rs10791837 chr11:65774596 C/T cg17712092 chr4:129076599 LARP1B -0.7 -9.81 -0.47 4.1e-20 Breast cancer; LUSC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg06634786 chr22:41940651 POLR3H 0.53 6.05 0.31 3.94e-9 Vitiligo; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.34 0.53 1.97e-25 Prudent dietary pattern; LUSC cis rs12928939 0.911 rs12919271 chr16:71792696 C/A cg03805757 chr16:71968109 PKD1L3 -0.43 -6.29 -0.33 1.01e-9 Post bronchodilator FEV1; LUSC cis rs7605827 0.930 rs2890487 chr2:15594938 A/G cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.26e-17 Educational attainment (years of education); LUSC cis rs28595532 0.920 rs17258830 chr4:119725543 A/T cg11846333 chr4:119757529 SEC24D -0.96 -6.85 -0.35 3.55e-11 Cannabis dependence symptom count; LUSC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg02782426 chr3:40428986 ENTPD3 -0.42 -7.81 -0.39 7.49e-14 Renal cell carcinoma; LUSC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg10360139 chr7:1886902 MAD1L1 -0.4 -6.09 -0.32 3.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg20243544 chr17:37824526 PNMT 0.48 6.79 0.35 5.08e-11 Asthma; LUSC trans rs6600671 0.934 rs12131379 chr1:121293437 T/C cg00646200 chr1:148855367 NA 0.47 7.35 0.37 1.58e-12 Hip geometry; LUSC cis rs3862030 0.836 rs12771867 chr10:104246691 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.62 -9.84 -0.47 3.12e-20 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs1865760 0.964 rs3799373 chr6:25929173 A/C cg17691542 chr6:26056736 HIST1H1C 0.46 6.95 0.36 1.95e-11 Height; LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.82 0.43 6.5e-17 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs62400317 0.723 rs1329709 chr6:44974956 G/T cg20913747 chr6:44695427 NA -0.46 -7.23 -0.37 3.41e-12 Total body bone mineral density; LUSC cis rs854765 0.547 rs4925135 chr17:17952868 T/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.18 -0.32 1.82e-9 Total body bone mineral density; LUSC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg04414720 chr1:150670196 GOLPH3L 0.53 8.33 0.41 2.16e-15 Melanoma; LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg13397359 chr6:42928475 GNMT -0.55 -9.39 -0.46 9.7e-19 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4319547 0.695 rs4758645 chr12:122946487 G/A cg05707623 chr12:122985044 ZCCHC8 -0.56 -7.15 -0.36 5.65e-12 Body mass index; LUSC cis rs35995292 0.534 rs2392607 chr7:38930380 G/A cg19327137 chr7:38886074 VPS41 0.55 10.38 0.49 4.47e-22 Subjective well-being (multi-trait analysis); LUSC cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg25036284 chr2:26402008 FAM59B -0.67 -9.29 -0.45 2.09e-18 Gut microbiome composition (summer); LUSC cis rs926938 0.584 rs360607 chr1:115392401 C/A cg12756093 chr1:115239321 AMPD1 0.46 7.05 0.36 1.01e-11 Autism; LUSC trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg03929089 chr4:120376271 NA 0.82 11.14 0.52 9.93e-25 Coronary artery disease; LUSC trans rs28647808 0.881 rs7029386 chr9:136263736 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs5744897 1.000 rs5744897 chr12:133226831 C/T cg26621607 chr12:133180238 NA 0.43 5.72 0.3 2.37e-8 Urate levels in overweight individuals; LUSC cis rs7107174 1.000 rs7128666 chr11:78102363 A/T cg02023728 chr11:77925099 USP35 0.46 6.78 0.35 5.58e-11 Testicular germ cell tumor; LUSC cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg12219531 chr12:120966889 COQ5 0.61 8.11 0.41 9.99e-15 High light scatter reticulocyte count; LUSC cis rs55665837 1.000 rs10832269 chr11:14465069 C/A cg05501817 chr11:14380813 RRAS2 -0.4 -6.54 -0.34 2.3e-10 Vitamin D levels; LUSC cis rs897984 0.542 rs7197717 chr16:31083075 A/C cg02466173 chr16:30829666 NA -0.49 -9.55 -0.46 2.86e-19 Dementia with Lewy bodies; LUSC cis rs12310956 0.510 rs1386936 chr12:33875369 G/A cg06521331 chr12:34319734 NA -0.37 -6.07 -0.32 3.51e-9 Morning vs. evening chronotype; LUSC trans rs561341 1.000 rs55962687 chr17:30260369 C/T cg27661571 chr11:113659931 NA -0.73 -8.05 -0.4 1.47e-14 Hip circumference adjusted for BMI; LUSC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg11632617 chr15:75315747 PPCDC -0.55 -7.1 -0.36 7.61e-12 Blood trace element (Zn levels); LUSC cis rs2109514 1.000 rs4727833 chr7:116147908 C/G cg12739419 chr7:116140593 CAV2 -0.29 -6.54 -0.34 2.33e-10 Prevalent atrial fibrillation; LUSC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.94 0.55 1.28e-27 Prudent dietary pattern; LUSC cis rs7188861 0.813 rs34787601 chr16:11399538 T/A cg00044050 chr16:11439710 C16orf75 0.51 5.83 0.3 1.32e-8 HDL cholesterol; LUSC cis rs6733011 0.508 rs4851173 chr2:99520608 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.93 -0.35 2.15e-11 Bipolar disorder; LUSC cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg06092702 chr1:163392909 NA -0.45 -7.42 -0.38 9.62e-13 Motion sickness; LUSC cis rs4319547 0.695 rs10846746 chr12:122868696 C/T cg23029597 chr12:123009494 RSRC2 0.75 9.51 0.46 3.94e-19 Body mass index; LUSC cis rs367615 0.552 rs7720036 chr5:108710699 A/G cg17395555 chr5:108820864 NA -0.52 -9.03 -0.44 1.43e-17 Colorectal cancer (SNP x SNP interaction); LUSC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.61 0.62 1.05e-37 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4129585 0.928 rs13262595 chr8:143316970 A/G cg16886403 chr8:143471632 TSNARE1 0.43 6.15 0.32 2.16e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs7119 0.651 rs35657172 chr15:77847813 T/C cg27398640 chr15:77910606 LINGO1 -0.33 -7.04 -0.36 1.12e-11 Type 2 diabetes; LUSC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg07703079 chr11:430292 ANO9 0.6 6.51 0.34 2.79e-10 Body mass index; LUSC cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg00409905 chr10:38381863 ZNF37A -0.36 -6.17 -0.32 2.02e-9 Extrinsic epigenetic age acceleration; LUSC cis rs7538876 0.903 rs6681150 chr1:17750685 G/A cg07965774 chr1:17746286 RCC2 0.32 6.05 0.31 3.94e-9 Basal cell carcinoma; LUSC cis rs12220238 1.000 rs10824114 chr10:75970503 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.22 0.37 3.42e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs847577 0.677 rs951988 chr7:97762474 C/G cg21770322 chr7:97807741 LMTK2 -0.49 -7.97 -0.4 2.58e-14 Breast cancer; LUSC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg22549504 chr19:17448937 GTPBP3 0.53 6.91 0.35 2.41e-11 Systemic lupus erythematosus; LUSC cis rs7647973 0.848 rs4292260 chr3:49148890 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.63 8.75 0.43 1.07e-16 Menarche (age at onset); LUSC cis rs6547741 1.000 rs1528404 chr2:27846603 C/T cg27432699 chr2:27873401 GPN1 -0.81 -15.22 -0.64 4.05e-40 Oral cavity cancer; LUSC cis rs1832871 0.683 rs11752399 chr6:158711188 G/A cg07165851 chr6:158734300 TULP4 0.5 7.66 0.39 2.05e-13 Height; LUSC cis rs3931020 0.688 rs525487 chr1:75217420 A/G cg21535942 chr1:75199100 CRYZ;TYW3 -0.48 -6.0 -0.31 5.12e-9 Resistin levels; LUSC cis rs2996428 0.561 rs12134919 chr1:3744641 G/A cg23277830 chr1:3704460 LRRC47 0.32 6.05 0.31 3.97e-9 Red cell distribution width; LUSC trans rs877282 0.945 rs11253397 chr10:789774 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs400736 0.930 rs370812 chr1:8075894 C/T cg25007680 chr1:8021821 PARK7 0.57 9.11 0.45 7.79e-18 Response to antidepressants and depression; LUSC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.78 0.6 1.56e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs7011049 0.908 rs72640860 chr8:53840500 G/A cg26025543 chr8:53854495 NA 0.52 6.3 0.33 9.5e-10 Systolic blood pressure; LUSC cis rs12291225 0.839 rs4757244 chr11:14258655 A/G cg05501817 chr11:14380813 RRAS2 0.42 6.3 0.33 9.17e-10 Sense of smell; LUSC cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg16405210 chr4:1374714 KIAA1530 -0.6 -9.23 -0.45 3.25e-18 Longevity; LUSC cis rs6582630 0.555 rs2197308 chr12:38281261 A/G cg26384229 chr12:38710491 ALG10B -0.56 -8.46 -0.42 8.29e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg23093090 chr10:104574429 C10orf26 -0.44 -7.85 -0.39 5.76e-14 Arsenic metabolism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13512204 chr9:78506874 PCSK5 0.41 6.29 0.33 9.93e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.44 0.33 4.14e-10 Lung cancer; LUSC cis rs73198271 0.531 rs3748142 chr8:8655355 G/A cg01851573 chr8:8652454 MFHAS1 0.71 9.08 0.44 9.6e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg22433210 chr17:43662623 NA 0.75 10.84 0.51 1.13e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs12220238 0.818 rs10824082 chr10:75904080 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.01 0.36 1.29e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs3803170 0.513 rs4766572 chr12:111830765 G/A cg10833066 chr12:111807467 FAM109A 0.38 7.17 0.37 4.88e-12 Mean corpuscular hemoglobin; LUSC cis rs9788682 0.747 rs8042059 chr15:78907859 A/C cg24631222 chr15:78858424 CHRNA5 0.61 8.69 0.43 1.6e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2274459 0.841 rs12203688 chr6:33693624 G/T cg06253072 chr6:33679850 C6orf125 -0.49 -5.92 -0.31 7.84e-9 Obesity (extreme); LUSC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg12311346 chr5:56204834 C5orf35 -0.58 -8.88 -0.44 4.06e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg05340658 chr4:99064831 C4orf37 0.57 9.48 0.46 4.88e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs3925075 0.966 rs7195915 chr16:31344455 A/G cg02846316 chr16:31340340 ITGAM 0.35 6.53 0.34 2.48e-10 IgA nephropathy; LUSC cis rs1559088 1.000 rs2161225 chr19:33551899 C/T cg03563238 chr19:33554763 RHPN2 -0.4 -6.38 -0.33 5.85e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.56 7.76 0.39 1.06e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2439831 0.717 rs2470132 chr15:43835481 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.71 0.39 1.41e-13 Lung cancer in ever smokers; LUSC trans rs2229238 0.911 rs73020246 chr1:154485640 A/G cg25273160 chr11:56955011 LRRC55 0.31 5.96 0.31 6.37e-9 Coronary heart disease; LUSC trans rs2832191 0.692 rs8134627 chr21:30349069 C/T cg14791747 chr16:20752902 THUMPD1 0.42 6.45 0.33 3.86e-10 Dental caries; LUSC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg15744005 chr10:104629667 AS3MT 0.31 6.4 0.33 5.33e-10 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 8.96 0.44 2.3e-17 Schizophrenia; LUSC cis rs981844 0.712 rs4632640 chr4:154742389 G/C cg14289246 chr4:154710475 SFRP2 -0.44 -6.13 -0.32 2.5e-9 Response to statins (LDL cholesterol change); LUSC cis rs1670533 0.932 rs2045067 chr4:1052355 C/T cg27284194 chr4:1044797 NA 0.57 8.46 0.42 8.22e-16 Recombination rate (females); LUSC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18099408 chr3:52552593 STAB1 -0.43 -7.52 -0.38 5.1e-13 Electroencephalogram traits; LUSC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg08125733 chr17:73851984 WBP2 0.47 6.64 0.34 1.26e-10 White matter hyperintensity burden; LUSC cis rs35883536 0.605 rs2133118 chr1:101034337 C/T cg06223162 chr1:101003688 GPR88 -0.47 -8.88 -0.44 4.29e-17 Monocyte count; LUSC cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg01119278 chr6:110721349 DDO -0.47 -8.47 -0.42 7.89e-16 Platelet distribution width; LUSC cis rs9311676 0.632 rs6774357 chr3:58361530 A/C cg13750441 chr3:58318267 PXK 0.34 6.66 0.34 1.1e-10 Systemic lupus erythematosus; LUSC cis rs9906944 0.742 rs4073893 chr17:47118523 A/G cg14634687 chr17:47094252 IGF2BP1 0.31 6.57 0.34 1.93e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg20528787 chr7:158032352 PTPRN2 0.33 6.09 0.32 3.02e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs12594515 0.967 rs11854477 chr15:45998345 A/C cg01629716 chr15:45996671 NA 0.39 5.89 0.31 9.27e-9 Waist circumference;Weight; LUSC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg24250549 chr1:154909240 PMVK 0.64 10.42 0.5 3.32e-22 Prostate cancer; LUSC cis rs478304 0.627 rs11227254 chr11:65454000 A/G cg05805236 chr11:65401703 PCNXL3 -0.63 -10.33 -0.49 6.71e-22 Acne (severe); LUSC cis rs2898681 0.581 rs730246 chr4:53680719 T/C cg00338735 chr4:53728038 RASL11B 0.43 5.81 0.3 1.46e-8 Optic nerve measurement (cup area); LUSC cis rs4499344 0.633 rs166311 chr19:33161246 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.74 11.49 0.53 5.76e-26 Mean platelet volume; LUSC cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg15691649 chr6:25882328 NA -0.39 -6.29 -0.33 1.01e-9 Blood metabolite levels; LUSC cis rs3820068 0.608 rs12740492 chr1:16048951 A/T cg24675056 chr1:15929824 NA 0.41 6.85 0.35 3.55e-11 Systolic blood pressure; LUSC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg03060546 chr3:49711283 APEH 0.66 7.33 0.37 1.74e-12 Menarche (age at onset); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg14385122 chr9:71320671 PIP5K1B 0.39 5.95 0.31 6.72e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg24578937 chr1:2090814 PRKCZ 0.46 10.43 0.5 3.12e-22 Height; LUSC cis rs7937682 0.921 rs34584980 chr11:111441537 G/A cg09085632 chr11:111637200 PPP2R1B 0.97 13.72 0.6 2.68e-34 Primary sclerosing cholangitis; LUSC cis rs11583043 0.872 rs1326380 chr1:101293753 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.87 0.31 1.05e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs10203711 1.000 rs12692239 chr2:239553947 T/C cg14580085 chr2:239553406 NA 0.41 6.9 0.35 2.64e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4888262 0.526 rs7205992 chr16:74590578 T/A cg01733217 chr16:74700730 RFWD3 0.75 12.24 0.56 1.05e-28 Testicular germ cell tumor; LUSC cis rs6494488 0.500 rs56095421 chr15:64911405 C/T cg08069370 chr15:64387884 SNX1 -0.65 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs7804356 1.000 rs6948657 chr7:26855943 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs897080 0.552 rs1067389 chr2:44642290 G/A cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.51e-8 Height; LUSC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg12463550 chr7:65579703 CRCP 0.48 6.89 0.35 2.73e-11 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26291818 chr8:61429582 RAB2A -0.44 -6.04 -0.31 4.15e-9 Bipolar disorder and schizophrenia; LUSC cis rs11971779 0.618 rs9640925 chr7:139085288 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17015704 chr6:119400380 FAM184A 0.47 7.28 0.37 2.39e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs868036 0.918 rs4776967 chr15:68033922 T/C cg08079166 chr15:68083412 MAP2K5 0.4 8.06 0.4 1.38e-14 Restless legs syndrome; LUSC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg06544989 chr22:39130855 UNC84B 0.33 5.65 0.3 3.51e-8 Menopause (age at onset); LUSC trans rs12682352 0.602 rs6993494 chr8:8667444 C/T cg21775007 chr8:11205619 TDH 0.45 6.21 0.32 1.6e-9 Neuroticism; LUSC cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg19628046 chr18:33552617 C18orf21 0.5 6.02 0.31 4.72e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg07507251 chr3:52567010 NT5DC2 -0.31 -6.13 -0.32 2.43e-9 Bipolar disorder; LUSC cis rs8114671 0.967 rs34515766 chr20:33785221 C/G cg07148914 chr20:33460835 GGT7 -0.44 -6.58 -0.34 1.82e-10 Height; LUSC cis rs7408868 1.000 rs10406754 chr19:15274201 T/A cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.1e-18 Pulse pressure; LUSC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg04369109 chr6:150039330 LATS1 -0.55 -8.2 -0.41 5.09e-15 Lung cancer; LUSC cis rs3820928 0.605 rs10186145 chr2:227781150 A/G cg11843606 chr2:227700838 RHBDD1 -0.64 -10.05 -0.48 6.37e-21 Pulmonary function; LUSC trans rs853679 0.517 rs4713152 chr6:28137454 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs35146811 0.735 rs1727140 chr7:99815399 T/A cg19116668 chr7:99932089 PMS2L1 0.34 5.87 0.31 1.05e-8 Coronary artery disease; LUSC cis rs2820315 0.964 rs2820311 chr1:201841476 A/G cg10061532 chr1:201886748 LMOD1 0.26 5.86 0.31 1.09e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs360798 0.512 rs2710642 chr2:63149557 G/A cg17519650 chr2:63277830 OTX1 0.52 7.21 0.37 3.87e-12 Coronary artery disease; LUSC cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg27446573 chr6:127587934 RNF146 0.8 12.78 0.57 1.04e-30 Breast cancer; LUSC cis rs4845570 1.000 rs1054479 chr1:151746079 A/T cg07092448 chr1:151763213 TDRKH -1.27 -14.41 -0.62 5.93e-37 Coronary artery disease; LUSC cis rs4975616 0.804 rs381949 chr5:1322468 G/A cg06550200 chr5:1325588 CLPTM1L -0.65 -10.92 -0.51 6.06e-24 Lung cancer; LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8.04e-17 Bipolar disorder; LUSC cis rs7615316 0.934 rs13085998 chr3:142263812 C/T cg16271453 chr3:142027066 XRN1 0.37 6.45 0.33 3.84e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs75920871 0.528 rs723955 chr11:116925042 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.42 -0.33 4.69e-10 Subjective well-being; LUSC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs7100689 0.646 rs2039757 chr10:82078868 C/A cg01528321 chr10:82214614 TSPAN14 0.82 12.36 0.56 3.74e-29 Post bronchodilator FEV1; LUSC cis rs6977660 1.000 rs10260527 chr7:19801930 G/A cg05791153 chr7:19748676 TWISTNB 0.59 6.47 0.33 3.52e-10 Thyroid stimulating hormone; LUSC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg25019033 chr10:957182 NA -0.52 -5.79 -0.3 1.62e-8 Eosinophil percentage of granulocytes; LUSC cis rs1979679 0.541 rs7956757 chr12:28723004 C/T cg13890972 chr12:28721907 NA -0.42 -6.07 -0.32 3.45e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs2637266 0.756 rs846609 chr10:78551718 A/G cg18941641 chr10:78392320 NA 0.38 6.81 0.35 4.57e-11 Pulmonary function; LUSC cis rs72781680 0.898 rs55657921 chr2:24008091 C/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs1670533 0.932 rs9992925 chr4:1050909 A/T cg19318889 chr4:1322082 MAEA 0.43 5.66 0.3 3.22e-8 Recombination rate (females); LUSC trans rs62103177 0.714 rs7227962 chr18:77603283 T/G cg05926928 chr17:57297772 GDPD1 1.06 13.32 0.59 9.15e-33 Opioid sensitivity; LUSC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC cis rs1448094 0.872 rs4919777 chr12:86358491 C/T cg02569458 chr12:86230093 RASSF9 0.41 6.53 0.34 2.52e-10 Major depressive disorder; LUSC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg18876405 chr7:65276391 NA -0.57 -9.09 -0.45 8.8e-18 Aortic root size; LUSC cis rs7178572 0.568 rs3743478 chr15:77400388 T/C cg22256960 chr15:77711686 NA -0.5 -7.88 -0.4 4.56e-14 Type 2 diabetes; LUSC trans rs17035310 0.618 rs4464576 chr4:106177882 C/T cg19865523 chr12:132537749 EP400 0.49 6.03 0.31 4.25e-9 Colorectal or endometrial cancer; LUSC cis rs7572644 0.541 rs2839791 chr2:28232279 A/C cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20382932 chr2:71357258 MCEE;MPHOSPH10 -0.33 -5.97 -0.31 6.04e-9 Electrocardiographic conduction measures; LUSC cis rs8060686 0.641 rs118035472 chr16:68242311 A/G cg04539111 chr16:67997858 SLC12A4 -0.43 -5.71 -0.3 2.51e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg07424592 chr7:64974309 NA 0.67 5.97 0.31 6.18e-9 Diabetic kidney disease; LUSC trans rs57221529 0.766 rs72703075 chr5:592819 C/T cg11887960 chr12:57824829 NA 0.57 6.83 0.35 4.12e-11 Lung disease severity in cystic fibrosis; LUSC cis rs8077889 0.917 rs9894873 chr17:41911832 A/G cg26893861 chr17:41843967 DUSP3 0.87 13.45 0.59 2.87e-33 Triglycerides; LUSC cis rs9611519 0.929 rs12484477 chr22:41429084 G/A cg13813247 chr22:41461852 NA -0.37 -6.68 -0.34 9.83e-11 Neuroticism; LUSC cis rs6840360 0.642 rs7676493 chr4:152426765 C/T cg20465933 chr4:152376761 FAM160A1 0.33 5.94 0.31 7.18e-9 Intelligence (multi-trait analysis); LUSC trans rs656319 0.629 rs10111315 chr8:9865588 G/A cg06636001 chr8:8085503 FLJ10661 -0.43 -6.32 -0.33 8.28e-10 Myopia (pathological); LUSC cis rs2439831 0.850 rs28513374 chr15:44125495 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.74 6.63 0.34 1.36e-10 Lung cancer in ever smokers; LUSC cis rs73198271 0.740 rs10112989 chr8:8647334 A/C cg15556689 chr8:8085844 FLJ10661 -0.47 -6.2 -0.32 1.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg00745463 chr17:30367425 LRRC37B -0.75 -9.07 -0.44 1.03e-17 Hip circumference adjusted for BMI; LUSC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.57 0.5 9.83e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9303280 0.836 rs12453507 chr17:38053207 C/G cg20243544 chr17:37824526 PNMT 0.4 6.07 0.32 3.51e-9 Self-reported allergy; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg20295408 chr7:1910781 MAD1L1 -0.49 -7.08 -0.36 8.76e-12 Bipolar disorder and schizophrenia; LUSC cis rs1124376 1.000 rs9828701 chr3:20149203 A/G cg05072819 chr3:20081367 KAT2B 0.66 7.55 0.38 4.18e-13 Bipolar disorder and schizophrenia; LUSC cis rs9653442 0.932 rs893245 chr2:100814893 C/T cg07810366 chr2:100720526 AFF3 -0.46 -7.86 -0.4 5.2e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs12210905 0.688 rs12199806 chr6:27435943 A/C cg08851530 chr6:28072375 NA 0.95 5.82 0.3 1.37e-8 Hip circumference adjusted for BMI; LUSC cis rs427941 0.703 rs201441 chr7:101737327 A/C cg06246474 chr7:101738831 CUX1 0.41 6.79 0.35 5.02e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg07507251 chr3:52567010 NT5DC2 0.33 6.42 0.33 4.79e-10 Bipolar disorder; LUSC cis rs7119 0.717 rs34981488 chr15:77723403 T/G cg05673287 chr15:77411982 SGK269 -0.44 -7.11 -0.36 7.14e-12 Type 2 diabetes; LUSC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs2303282 0.716 rs2550303 chr16:56395610 G/A cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs4660306 0.961 rs12082256 chr1:45951380 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -7.09 -0.36 7.98e-12 Homocysteine levels; LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.48 0.38 6.51e-13 Bipolar disorder; LUSC cis rs7829975 0.606 rs891570 chr8:8794454 G/A cg06636001 chr8:8085503 FLJ10661 -0.54 -8.71 -0.43 1.46e-16 Mood instability; LUSC cis rs8099014 1.000 rs4940710 chr18:56135390 C/G cg12907477 chr18:56117327 MIR122 0.4 6.09 0.32 3.17e-9 Platelet count; LUSC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.59 0.43 3.4e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg22535103 chr8:58192502 C8orf71 -0.58 -6.86 -0.35 3.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg02931644 chr1:25747376 RHCE 0.37 6.76 0.35 6.06e-11 Erythrocyte sedimentation rate; LUSC trans rs7726839 0.574 rs72707007 chr5:661856 T/C cg25482853 chr8:67687455 SGK3 1.1 15.91 0.66 8.06e-43 Obesity-related traits; LUSC cis rs80130819 0.688 rs4760698 chr12:48592872 C/T cg24011408 chr12:48396354 COL2A1 0.45 5.82 0.3 1.39e-8 Prostate cancer; LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg13047869 chr3:10149882 C3orf24 0.61 8.74 0.43 1.18e-16 Alzheimer's disease; LUSC cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg27446573 chr6:127587934 RNF146 0.71 10.91 0.51 6.5e-24 Breast cancer; LUSC cis rs8017423 0.967 rs11627528 chr14:90719697 C/A cg14092571 chr14:90743983 NA 0.37 6.08 0.32 3.3e-9 Mortality in heart failure; LUSC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg06212747 chr3:49208901 KLHDC8B 0.44 6.01 0.31 4.94e-9 Parkinson's disease; LUSC trans rs7170930 0.541 rs67543551 chr15:66535599 T/G cg06396762 chr16:3202609 NA -0.72 -5.97 -0.31 6.08e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg03036452 chr22:46663545 TTC38 0.53 5.76 0.3 1.94e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 2.83e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg25258033 chr6:167368657 RNASET2 -0.47 -7.95 -0.4 2.87e-14 Crohn's disease; LUSC cis rs1577917 0.917 rs13213603 chr6:86534758 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.81 -0.35 4.49e-11 Response to antipsychotic treatment; LUSC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg17366294 chr4:99064904 C4orf37 0.6 10.58 0.5 9.38e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs4253772 0.591 rs11703435 chr22:46685563 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.6 5.83 0.3 1.3e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.4 -6.42 -0.33 4.56e-10 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.771 rs2842602 chr6:86331887 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -11.02 -0.52 2.62e-24 Response to antipsychotic treatment; LUSC cis rs11792861 0.781 rs11789252 chr9:111762010 A/T cg05043794 chr9:111880884 C9orf5 -0.38 -7.85 -0.39 5.79e-14 Menarche (age at onset); LUSC cis rs6960043 0.818 rs2358158 chr7:15054063 T/C cg19272540 chr7:15055459 NA 0.35 8.72 0.43 1.33e-16 Type 2 diabetes; LUSC cis rs9326248 0.510 rs4938332 chr11:116930798 A/G cg26566898 chr11:117069891 TAGLN 0.35 6.69 0.34 9.68e-11 Blood protein levels; LUSC cis rs6500395 0.963 rs2111242 chr16:48708300 T/C cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg18132916 chr6:79620363 NA 0.38 5.88 0.31 1.02e-8 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg20203395 chr5:56204925 C5orf35 0.58 8.6 0.43 3.13e-16 Initial pursuit acceleration; LUSC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg09085632 chr11:111637200 PPP2R1B -1.03 -16.29 -0.67 2.44e-44 Primary sclerosing cholangitis; LUSC cis rs1413885 0.516 rs716592 chr1:65843982 C/T cg14976592 chr1:65886160 LEPROT;LEPR -0.5 -7.41 -0.38 1.05e-12 Anticoagulant levels; LUSC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg18230493 chr5:56204884 C5orf35 -0.92 -14.02 -0.61 1.94e-35 Initial pursuit acceleration; LUSC cis rs193541 0.585 rs4546376 chr5:122089106 C/A cg19077854 chr5:122220652 SNX24 0.28 6.26 0.32 1.18e-9 Glucose homeostasis traits; LUSC cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg22963979 chr7:1858916 MAD1L1 -0.7 -11.67 -0.54 1.28e-26 Bipolar disorder and schizophrenia; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.49 -8.11 -0.41 9.9e-15 Lymphocyte counts; LUSC cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg17366294 chr4:99064904 C4orf37 0.59 10.55 0.5 1.18e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg08493051 chr2:3487164 NA -0.53 -8.06 -0.4 1.42e-14 Neurofibrillary tangles; LUSC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg06287003 chr12:125626642 AACS -0.39 -6.48 -0.33 3.26e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs926938 0.505 rs360629 chr1:115414733 A/G cg01522456 chr1:115632236 TSPAN2 -0.38 -5.77 -0.3 1.82e-8 Autism; LUSC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg18404041 chr3:52824283 ITIH1 -0.5 -9.51 -0.46 4.04e-19 Bipolar disorder; LUSC cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.16 0.41 6.79e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg21724239 chr8:58056113 NA 0.58 7.15 0.36 5.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg19717773 chr7:2847554 GNA12 -0.37 -5.95 -0.31 6.8e-9 Height; LUSC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.84 0.3 1.25e-8 Menopause (age at onset); LUSC cis rs9287719 0.901 rs4555317 chr2:10744247 A/G cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs3947 1.000 rs1736081 chr8:11702840 T/G cg00262122 chr8:11665843 FDFT1 -0.48 -5.77 -0.3 1.79e-8 Blood protein levels; LUSC cis rs11190604 1.000 rs10883510 chr10:102297018 C/T cg07080220 chr10:102295463 HIF1AN 0.69 8.73 0.43 1.2e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg13535736 chr9:111863775 C9orf5 -0.41 -6.81 -0.35 4.48e-11 Menarche (age at onset); LUSC cis rs3806843 1.000 rs3822346 chr5:140187322 C/T cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs7605827 0.930 rs11893303 chr2:15613715 G/A cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg26897989 chr16:1907736 C16orf73 -0.44 -6.86 -0.35 3.32e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs17572109 0.666 rs11696005 chr2:219229641 T/C cg00012203 chr2:219082015 ARPC2 -0.47 -6.1 -0.32 2.9e-9 Platelet count;Platelet distribution width;Mean platelet volume; LUSC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg14664628 chr15:75095509 CSK -0.49 -7.01 -0.36 1.32e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs8062405 0.964 rs9972768 chr16:28861734 A/C cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs3771570 0.681 rs12151655 chr2:242281438 T/A cg21155796 chr2:242212141 HDLBP 0.63 6.86 0.35 3.32e-11 Prostate cancer; LUSC cis rs10876993 0.855 rs1689585 chr12:58080140 A/G cg18357645 chr12:58087776 OS9 -0.55 -8.24 -0.41 3.86e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs2486288 0.656 rs12440356 chr15:45567529 T/C cg14582100 chr15:45693742 SPATA5L1 0.44 7.79 0.39 8.31e-14 Glomerular filtration rate; LUSC trans rs7939886 0.920 rs11227463 chr11:55955447 C/T cg15704280 chr7:45808275 SEPT13 0.89 6.88 0.35 3e-11 Myopia (pathological); LUSC trans rs28647808 0.881 rs71483207 chr9:136258698 A/G cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs6087771 0.714 rs6058259 chr20:30235302 A/G cg21427119 chr20:30132790 HM13 -0.37 -5.98 -0.31 5.71e-9 Subcortical brain region volumes;Putamen volume; LUSC cis rs17818399 0.502 rs1451152 chr2:46800150 C/T cg02822958 chr2:46747628 ATP6V1E2 0.35 5.71 0.3 2.49e-8 Height; LUSC cis rs12541635 0.966 rs16873989 chr8:106966381 C/T cg10147462 chr8:107024639 NA 0.56 9.76 0.47 5.99e-20 Age of smoking initiation; LUSC cis rs921968 0.565 rs1554622 chr2:219606218 T/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.0 -0.48 9.34e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs7818345 0.967 rs12678336 chr8:19280552 C/A cg11303988 chr8:19266685 CSGALNACT1 0.39 7.48 0.38 6.63e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs5753037 0.629 rs140138 chr22:30164628 T/G cg11564601 chr22:30592435 NA 0.33 5.76 0.3 1.92e-8 Type 1 diabetes; LUSC cis rs7582180 0.903 rs13033057 chr2:100896415 C/T cg08017756 chr2:100939284 LONRF2 -0.36 -6.01 -0.31 4.77e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg11062466 chr8:58055876 NA 0.49 6.77 0.35 5.65e-11 Developmental language disorder (linguistic errors); LUSC cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs912057 0.601 rs1294405 chr6:6737591 A/G cg06612196 chr6:6737390 NA 0.63 13.14 0.58 4.41e-32 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs611744 0.625 rs4735055 chr8:109286642 G/A cg21045802 chr8:109455806 TTC35 0.46 7.07 0.36 9.34e-12 Dupuytren's disease; LUSC trans rs7647973 0.593 rs59684465 chr3:49874246 C/T cg21659725 chr3:3221576 CRBN 0.71 8.64 0.43 2.41e-16 Menarche (age at onset); LUSC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg00310523 chr12:86230176 RASSF9 0.47 8.39 0.42 1.37e-15 Major depressive disorder; LUSC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg15448220 chr1:150897856 SETDB1 0.42 6.13 0.32 2.51e-9 Melanoma; LUSC cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.4 0.53 1.17e-25 Colorectal cancer; LUSC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg06713675 chr4:122721982 EXOSC9 -0.46 -8.15 -0.41 7.48e-15 Type 2 diabetes; LUSC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg14668632 chr7:2872130 GNA12 -0.41 -6.22 -0.32 1.5e-9 Height; LUSC trans rs7045881 0.735 rs10967594 chr9:26910951 G/T cg10990997 chr6:39873526 MOCS1 -0.38 -6.06 -0.31 3.59e-9 Schizophrenia; LUSC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.64 -0.34 1.3e-10 Blood protein levels; LUSC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg05855489 chr10:104503620 C10orf26 0.67 10.29 0.49 9.39e-22 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs3741151 0.656 rs11544311 chr11:73106237 A/C cg17517138 chr11:73019481 ARHGEF17 0.97 8.28 0.41 3.08e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18404041 chr3:52824283 ITIH1 -0.53 -10.2 -0.49 1.97e-21 Electroencephalogram traits; LUSC cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.94 13.56 0.6 1.1e-33 Chronic sinus infection; LUSC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.3 0.49 8.56e-22 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.909 rs28668716 chr4:120309875 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs9527 0.590 rs2148198 chr10:104915310 A/G cg05855489 chr10:104503620 C10orf26 -0.51 -7.64 -0.39 2.33e-13 Arsenic metabolism; LUSC cis rs12986413 0.967 rs1015670 chr19:2171490 G/A cg09261902 chr19:2140048 AP3D1 0.31 5.93 0.31 7.5e-9 Height; LUSC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC cis rs6693567 0.565 rs10888578 chr1:150260993 A/G cg15654264 chr1:150340011 RPRD2 -0.46 -7.44 -0.38 8.38e-13 Migraine; LUSC cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs734999 0.588 rs6701238 chr1:2520500 G/A cg18854424 chr1:2615690 NA 0.51 10.34 0.49 6.28e-22 Ulcerative colitis; LUSC cis rs6542838 0.611 rs17758170 chr2:99531842 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.55 -0.34 2.21e-10 Fear of minor pain; LUSC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg25258033 chr6:167368657 RNASET2 -0.47 -7.82 -0.39 7.18e-14 Crohn's disease; LUSC cis rs6964587 0.933 rs10271174 chr7:91785970 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.77 0.3 1.77e-8 Breast cancer; LUSC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg13119609 chr19:45449297 APOC2 0.5 9.92 0.48 1.65e-20 Blood protein levels; LUSC cis rs4919694 1.000 rs78893207 chr10:104796138 T/C cg04362960 chr10:104952993 NT5C2 1.17 13.66 0.6 4.72e-34 Arsenic metabolism; LUSC cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg17063962 chr7:91808500 NA 0.6 9.38 0.46 1.02e-18 Breast cancer; LUSC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg11812906 chr14:75593930 NEK9 -0.66 -11.18 -0.52 7.19e-25 Height; LUSC cis rs1595825 0.891 rs73054819 chr2:198625744 G/T cg10547527 chr2:198650123 BOLL -0.52 -6.07 -0.31 3.57e-9 Ulcerative colitis; LUSC cis rs10419226 0.577 rs7257812 chr19:18787372 A/G cg22001208 chr19:18782374 NA -0.38 -6.45 -0.33 3.85e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs2120019 0.567 rs8025170 chr15:75170983 A/G cg17294928 chr15:75287854 SCAMP5 0.64 7.16 0.36 5.22e-12 Blood trace element (Zn levels); LUSC cis rs10186029 0.616 rs12616255 chr2:213978895 T/A cg08319019 chr2:214017104 IKZF2 0.57 8.28 0.41 2.97e-15 Systemic sclerosis; LUSC cis rs17621444 0.522 rs10788020 chr10:121808870 A/G cg02041677 chr10:121771263 NA -0.34 -6.4 -0.33 5.35e-10 IgG glycosylation; LUSC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.21 -0.49 1.74e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs425277 1.000 rs809912 chr1:2078385 C/T cg03732007 chr1:2071316 PRKCZ 0.47 7.62 0.38 2.68e-13 Height; LUSC cis rs12908161 1.000 rs62019464 chr15:85294469 T/A cg12863693 chr15:85201151 NMB 0.41 8.48 0.42 7.34e-16 Schizophrenia; LUSC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg03538708 chr1:25844672 NA -0.37 -6.08 -0.32 3.23e-9 Erythrocyte sedimentation rate; LUSC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.81 0.39 7.68e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11644478 chr21:40555479 PSMG1 -0.68 -10.63 -0.5 6.1e-23 Menarche (age at onset); LUSC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg26839252 chr6:160211577 TCP1;MRPL18 -0.46 -6.06 -0.31 3.6e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg05535760 chr7:792225 HEATR2 0.81 9.7 0.47 9.49e-20 Cerebrospinal P-tau181p levels; LUSC cis rs1044826 0.642 rs167187 chr3:139237008 C/T cg15131784 chr3:139108705 COPB2 -0.41 -6.5 -0.34 2.86e-10 Obesity-related traits; LUSC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg26384229 chr12:38710491 ALG10B 0.93 17.4 0.69 1.02e-48 Heart rate; LUSC cis rs7553864 0.614 rs4559475 chr1:87614236 T/C cg17420885 chr1:87600446 LOC339524 -0.5 -6.98 -0.36 1.6e-11 Smoking behavior; LUSC cis rs939658 0.805 rs34222382 chr15:79440748 C/T cg17916960 chr15:79447300 NA -0.53 -10.71 -0.51 3.31e-23 Refractive error; LUSC cis rs763121 0.962 rs6001159 chr22:38966487 A/G cg06022373 chr22:39101656 GTPBP1 0.75 12.1 0.55 3.37e-28 Menopause (age at onset); LUSC cis rs965469 1.000 rs6051672 chr20:3224819 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -6.02 -0.31 4.62e-9 IFN-related cytopenia; LUSC cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.03 0.55 6.07e-28 Chronic sinus infection; LUSC cis rs1371867 0.846 rs1660346 chr8:101312497 A/G cg00191853 chr8:101177733 SPAG1 -0.41 -6.59 -0.34 1.68e-10 Atrioventricular conduction; LUSC cis rs2425143 0.512 rs11699653 chr20:34622916 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.16 -0.32 2.11e-9 Blood protein levels; LUSC cis rs2073300 1.000 rs6048810 chr20:23446429 G/A cg09953122 chr20:23471693 CST8 -0.75 -6.87 -0.35 3.15e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7296418 0.961 rs1790106 chr12:123591596 G/T cg06742321 chr12:123595122 PITPNM2 0.39 5.75 0.3 2.07e-8 Platelet count; LUSC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 8.85 0.44 5.33e-17 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17253792 0.915 rs79894275 chr14:56180285 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs644799 0.544 rs1527450 chr11:95467777 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.64 9.71 0.47 8.77e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.19 0.37 4.3e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.85 -0.35 3.61e-11 Neuroticism; LUSC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11644478 chr21:40555479 PSMG1 -0.84 -15.3 -0.64 2.06e-40 Cognitive function; LUSC trans rs11098499 0.954 rs6838814 chr4:120392443 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.22e-9 Corneal astigmatism; LUSC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg14416726 chr6:151773293 C6orf211;RMND1 0.7 11.4 0.53 1.15e-25 Menarche (age at onset); LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg08280861 chr8:58055591 NA 0.55 6.51 0.34 2.73e-10 Developmental language disorder (linguistic errors); LUSC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg20203395 chr5:56204925 C5orf35 -0.56 -8.05 -0.4 1.49e-14 Coronary artery disease; LUSC cis rs8103278 0.662 rs16980051 chr19:46345886 T/C cg14061069 chr19:46274453 DMPK -0.38 -6.41 -0.33 4.89e-10 Coronary artery disease; LUSC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg17279839 chr7:150038598 RARRES2 0.43 7.1 0.36 7.76e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs12220238 0.558 rs76330316 chr10:76002291 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.05 0.36 1.04e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs963731 0.649 rs4670903 chr2:39220975 G/A cg04010122 chr2:39346883 SOS1 -0.77 -5.7 -0.3 2.64e-8 Corticobasal degeneration; LUSC cis rs10927875 0.619 rs7537101 chr1:16150384 T/C cg22431228 chr1:16359049 CLCNKA 0.35 7.29 0.37 2.31e-12 Dilated cardiomyopathy; LUSC cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.42e-16 Menopause (age at onset); LUSC cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg06552810 chr11:31128660 NA -0.41 -7.25 -0.37 2.89e-12 Red blood cell count; LUSC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg24846343 chr22:24311635 DDTL -0.75 -16.47 -0.67 4.96e-45 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9653442 0.564 rs6707067 chr2:100767232 G/A cg22139774 chr2:100720529 AFF3 -0.42 -7.07 -0.36 9.09e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs908922 0.651 rs4845442 chr1:152485545 G/A cg20991723 chr1:152506922 NA 0.5 9.21 0.45 3.71e-18 Hair morphology; LUSC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg27124370 chr19:33622961 WDR88 -0.58 -8.31 -0.41 2.4e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9486719 1.000 rs4078038 chr6:96904366 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.86 -0.47 2.63e-20 Migraine;Coronary artery disease; LUSC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.81 -13.07 -0.58 8.52e-32 Platelet count; LUSC trans rs11700980 0.551 rs2832008 chr21:30109998 T/C cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg19774624 chr17:42201019 HDAC5 -0.8 -13.02 -0.58 1.22e-31 Total body bone mineral density; LUSC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.930 rs6431711 chr2:15683930 G/T cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs10193935 0.818 rs2374428 chr2:42667961 T/C cg27598129 chr2:42591480 NA 0.59 8.02 0.4 1.79e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11758351 0.660 rs56398712 chr6:26213868 A/G cg23601095 chr6:26197514 HIST1H3D 0.67 7.29 0.37 2.26e-12 Gout;Renal underexcretion gout; LUSC cis rs2806561 0.704 rs667330 chr1:23515257 A/G cg19743168 chr1:23544995 NA 0.4 7.81 0.39 7.42e-14 Height; LUSC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg13206674 chr6:150067644 NUP43 0.61 9.72 0.47 8.16e-20 Lung cancer; LUSC cis rs1371867 0.846 rs1788199 chr8:101292854 A/G cg06002616 chr8:101225028 SPAG1 -0.46 -7.56 -0.38 3.93e-13 Atrioventricular conduction; LUSC cis rs12410462 0.681 rs6670816 chr1:227610592 G/T cg23173402 chr1:227635558 NA -0.64 -7.37 -0.37 1.35e-12 Major depressive disorder; LUSC cis rs10504229 0.871 rs7002070 chr8:58153817 A/G cg08219700 chr8:58056026 NA 0.44 5.75 0.3 2.01e-8 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg18681998 chr4:17616180 MED28 -0.79 -13.6 -0.6 7.62e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2692947 0.770 rs2579552 chr2:96737083 A/G cg22654517 chr2:96458247 NA 0.33 6.21 0.32 1.58e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs2652834 0.851 rs4238370 chr15:63347363 T/G cg05507819 chr15:63340323 TPM1 0.69 8.7 0.43 1.54e-16 HDL cholesterol; LUSC cis rs10197940 0.662 rs4335940 chr2:152275304 A/G cg19508488 chr2:152266495 RIF1 -0.45 -6.53 -0.34 2.52e-10 Lung cancer; LUSC cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.08 20.92 0.75 1.06e-62 Cognitive ability; LUSC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.57 0.38 3.71e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg07694864 chr17:40700509 NA -0.37 -5.96 -0.31 6.54e-9 Colorectal or endometrial cancer; LUSC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg00750074 chr16:89608354 SPG7 -0.53 -9.63 -0.47 1.54e-19 Multiple myeloma (IgH translocation); LUSC cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg08807101 chr21:30365312 RNF160 0.81 15.55 0.65 2.07e-41 Dental caries; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05994294 chr4:1374658 KIAA1530 0.48 6.24 0.32 1.29e-9 Bipolar disorder and schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14453326 chr12:124086472 DDX55 -0.43 -6.31 -0.33 9e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg03146154 chr1:46216737 IPP 0.52 7.67 0.39 1.94e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9463078 0.547 rs4711798 chr6:44750777 A/G cg25276700 chr6:44698697 NA -0.28 -5.96 -0.31 6.26e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg04733989 chr22:42467013 NAGA 0.61 9.48 0.46 4.84e-19 Schizophrenia; LUSC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg18230493 chr5:56204884 C5orf35 -0.66 -10.27 -0.49 1.07e-21 Coronary artery disease; LUSC cis rs4594175 0.926 rs4318127 chr14:51624897 G/C cg23942311 chr14:51606299 NA 0.31 5.86 0.31 1.11e-8 Cancer; LUSC cis rs61931739 0.534 rs814669 chr12:34102459 C/T cg06521331 chr12:34319734 NA -0.52 -8.62 -0.43 2.69e-16 Morning vs. evening chronotype; LUSC cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg20701182 chr2:24300061 SF3B14 0.87 11.34 0.53 1.97e-25 Lymphocyte counts; LUSC cis rs2250402 0.510 rs2291621 chr15:40324837 C/T cg20059928 chr15:40361485 NA -0.49 -5.96 -0.31 6.34e-9 Corneal curvature; LUSC cis rs7193541 0.691 rs3851728 chr16:74480660 C/T cg01733217 chr16:74700730 RFWD3 0.75 12.59 0.57 5.28e-30 Multiple myeloma; LUSC cis rs12971120 0.891 rs2278159 chr18:72178161 T/C cg25817165 chr18:72167213 CNDP2 -0.7 -8.33 -0.41 2.15e-15 Refractive error; LUSC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg19230755 chr7:65878503 NA 0.41 5.76 0.3 1.95e-8 Aortic root size; LUSC cis rs1891275 0.515 rs4244930 chr10:93466849 T/C cg07889827 chr10:93443413 NA -0.38 -8.57 -0.42 3.97e-16 Intelligence (multi-trait analysis); LUSC cis rs2980439 0.556 rs2921059 chr8:8317887 G/T cg08975724 chr8:8085496 FLJ10661 0.52 7.83 0.39 6.39e-14 Neuroticism; LUSC cis rs7980687 0.628 rs2102949 chr12:123676763 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.71 -0.34 8.3e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs478304 0.627 rs1073602 chr11:65455386 G/C cg27068330 chr11:65405492 SIPA1 -0.74 -10.3 -0.49 8.46e-22 Acne (severe); LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.98 -20.86 -0.75 1.78e-62 Prudent dietary pattern; LUSC cis rs1395 0.813 rs11685326 chr2:27453679 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.19 0.37 4.2e-12 Blood metabolite levels; LUSC cis rs7959452 0.718 rs10878963 chr12:69717166 T/G cg20891283 chr12:69753455 YEATS4 0.52 8.4 0.42 1.34e-15 Blood protein levels; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -8.1 -0.41 1.05e-14 Electroencephalogram traits; LUSC cis rs7572644 0.699 rs898034 chr2:28090820 T/C cg27432699 chr2:27873401 GPN1 -0.52 -6.72 -0.35 7.73e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg02711726 chr17:80685570 FN3KRP 0.4 6.21 0.32 1.61e-9 Glycated hemoglobin levels; LUSC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg11742103 chr11:62369870 EML3;MTA2 0.54 8.87 0.44 4.41e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg08470875 chr2:26401718 FAM59B 0.71 9.62 0.47 1.68e-19 Gut microbiome composition (summer); LUSC cis rs8060686 0.841 rs56374641 chr16:67908713 G/T cg27539214 chr16:67997921 SLC12A4 -0.46 -5.95 -0.31 6.59e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs931812 0.895 rs4236763 chr8:101913022 G/A cg20993868 chr7:22813445 NA 0.63 11.25 0.52 4.03e-25 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs2235649 0.789 rs4567715 chr16:1849363 G/C cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.06 -0.31 3.76e-9 Blood metabolite levels; LUSC cis rs6500602 0.653 rs3747579 chr16:4445327 A/G cg08645402 chr16:4508243 NA -0.39 -6.24 -0.32 1.35e-9 Schizophrenia; LUSC cis rs1355223 0.583 rs1396880 chr11:34870552 C/T cg11058730 chr11:34937778 PDHX;APIP -0.65 -10.67 -0.5 4.66e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6456156 0.586 rs2345753 chr6:167484344 T/A cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.33 0.56 4.97e-29 Chronic sinus infection; LUSC trans rs1728785 1.000 rs1749793 chr16:68569312 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.63 0.39 2.44e-13 Ulcerative colitis; LUSC cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg13010199 chr12:38710504 ALG10B 0.67 10.37 0.49 4.91e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs2463822 0.583 rs72919477 chr11:62042403 G/C cg06239285 chr11:62104954 ASRGL1 -0.65 -6.65 -0.34 1.19e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -5.71 -0.3 2.44e-8 Developmental language disorder (linguistic errors); LUSC cis rs2274273 1.000 rs4644 chr14:55604935 C/A cg04306507 chr14:55594613 LGALS3 0.54 11.53 0.53 3.94e-26 Protein biomarker; LUSC cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg17691542 chr6:26056736 HIST1H1C -0.48 -6.81 -0.35 4.55e-11 Iron status biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12810560 chr5:130500164 HINT1 -0.42 -6.36 -0.33 6.61e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9916302 0.861 rs11078913 chr17:37671714 G/T cg07936489 chr17:37558343 FBXL20 -0.7 -9.44 -0.46 6.37e-19 Glomerular filtration rate (creatinine); LUSC cis rs6424115 1.000 rs2179395 chr1:24148365 T/C cg10978503 chr1:24200527 CNR2 0.51 11.64 0.54 1.66e-26 Immature fraction of reticulocytes; LUSC cis rs11112613 0.680 rs12231332 chr12:106046030 G/A cg03607813 chr12:105948248 NA 0.41 5.9 0.31 8.85e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs6598955 0.724 rs12732295 chr1:26602251 C/T cg04990556 chr1:26633338 UBXN11 -0.78 -14.59 -0.62 1.26e-37 Obesity-related traits; LUSC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg12257692 chr3:49977190 RBM6 -0.26 -7.41 -0.38 1.02e-12 Body mass index; LUSC cis rs1448094 1.000 rs4919776 chr12:86353763 T/C cg02569458 chr12:86230093 RASSF9 0.41 6.54 0.34 2.35e-10 Major depressive disorder; LUSC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs4786125 0.587 rs12709158 chr16:6925056 A/G cg03623568 chr16:6915990 A2BP1 -0.5 -8.22 -0.41 4.41e-15 Heart rate variability traits (SDNN); LUSC cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg17366294 chr4:99064904 C4orf37 0.51 8.8 0.43 7.36e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7681440 0.904 rs28403500 chr4:90769729 T/G cg01966878 chr4:90757139 SNCA -0.34 -5.94 -0.31 7.11e-9 Dementia with Lewy bodies; LUSC trans rs7339349 0.605 rs4885139 chr13:74542950 A/T cg25826913 chr13:45885329 NA 0.59 6.21 0.32 1.61e-9 Neurofibrillary tangles; LUSC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg23758822 chr17:41437982 NA 1.04 19.44 0.73 7.67e-57 Menopause (age at onset); LUSC cis rs2404602 0.740 rs34924128 chr15:76965169 T/G cg26408565 chr15:76604113 ETFA -0.48 -7.63 -0.39 2.46e-13 Blood metabolite levels; LUSC cis rs61931739 0.782 rs1197569 chr12:34186733 A/T cg06521331 chr12:34319734 NA -0.35 -5.94 -0.31 7.11e-9 Morning vs. evening chronotype; LUSC trans rs7615952 0.546 rs16836896 chr3:125311262 A/T cg07211511 chr3:129823064 LOC729375 -0.56 -6.49 -0.33 3.15e-10 Blood pressure (smoking interaction); LUSC cis rs9807989 0.839 rs4988956 chr2:102968007 G/A cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg04317338 chr11:64019027 PLCB3 0.68 7.75 0.39 1.12e-13 Mean platelet volume; LUSC cis rs7100689 0.646 rs1290317 chr10:82062531 C/A cg00277334 chr10:82204260 NA -0.58 -8.65 -0.43 2.21e-16 Post bronchodilator FEV1; LUSC cis rs4363385 0.747 rs3964619 chr1:152972811 A/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.83 -0.39 6.43e-14 Inflammatory skin disease; LUSC trans rs2840044 1.000 rs225262 chr17:33959697 A/G cg19694781 chr19:47549865 TMEM160 -0.58 -9.31 -0.45 1.71e-18 Response to radiotherapy in cancer (late toxicity); LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.86 -0.35 3.45e-11 Bipolar disorder and schizophrenia; LUSC cis rs10783615 0.719 rs1975471 chr12:54336981 A/G cg17410650 chr12:54324560 NA -0.47 -6.26 -0.32 1.16e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs17401966 1.000 rs35837142 chr1:10322358 C/G cg19773385 chr1:10388646 KIF1B -0.53 -8.25 -0.41 3.6e-15 Hepatocellular carcinoma; LUSC cis rs7188861 0.768 rs12922733 chr16:11380670 C/G cg00044050 chr16:11439710 C16orf75 0.58 6.41 0.33 4.96e-10 HDL cholesterol; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg02951883 chr7:2050386 MAD1L1 -0.59 -10.61 -0.5 7.48e-23 Bipolar disorder and schizophrenia; LUSC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg15691649 chr6:25882328 NA 0.39 6.44 0.33 4.09e-10 Blood metabolite levels; LUSC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg06850241 chr22:41845214 NA -0.31 -6.01 -0.31 4.93e-9 Vitiligo; LUSC cis rs3087591 1.000 rs2040791 chr17:29627297 G/C cg24425628 chr17:29625626 OMG;NF1 -0.55 -7.89 -0.4 4.22e-14 Hip circumference; LUSC trans rs4714291 0.963 rs1923489 chr6:40023088 T/C cg02267698 chr19:7991119 CTXN1 0.52 7.25 0.37 2.91e-12 Strep throat; LUSC cis rs2455601 0.744 rs11042107 chr11:8905871 G/T cg21881798 chr11:8931708 C11orf17;ST5 -0.52 -7.4 -0.38 1.11e-12 Schizophrenia; LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.78 12.24 0.56 1.03e-28 Hip circumference adjusted for BMI; LUSC cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.25 0.56 9.46e-29 Colorectal cancer; LUSC cis rs2204008 0.580 rs1315373 chr12:38179114 T/G cg26384229 chr12:38710491 ALG10B -0.67 -10.46 -0.5 2.39e-22 Bladder cancer; LUSC cis rs10927875 0.632 rs6699394 chr1:16145143 C/A cg22431228 chr1:16359049 CLCNKA 0.34 6.5 0.34 2.94e-10 Dilated cardiomyopathy; LUSC cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.18 27.62 0.83 2.92e-88 Chronic sinus infection; LUSC cis rs9527 0.590 rs10883830 chr10:104851285 G/A cg05855489 chr10:104503620 C10orf26 0.52 7.96 0.4 2.72e-14 Arsenic metabolism; LUSC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg04871131 chr7:94954202 PON1 -0.38 -6.12 -0.32 2.68e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg11812906 chr14:75593930 NEK9 0.67 11.56 0.53 3.11e-26 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04402966 chr7:87505783 SLC25A40;DBF4 -0.43 -6.4 -0.33 5.28e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9811920 0.625 rs7631174 chr3:99913902 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.33 6.28 0.33 1.03e-9 Axial length; LUSC cis rs10752881 0.839 rs6692207 chr1:183085304 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Colorectal cancer; LUSC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1034435 0.547 rs5767174 chr22:48898857 A/G cg05992904 chr22:48892994 FAM19A5 -0.38 -6.69 -0.34 9.6e-11 Late-onset Alzheimer's disease; LUSC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg13531842 chr10:38383804 ZNF37A -0.44 -6.72 -0.35 7.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.14 0.41 8.18e-15 Prudent dietary pattern; LUSC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.77 0.63 2.41e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.955 rs13129661 chr4:120152909 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.21 0.32 1.6e-9 Corneal astigmatism; LUSC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.76 -9.76 -0.47 5.72e-20 Gut microbiome composition (summer); LUSC cis rs2348418 0.715 rs11049719 chr12:28720379 A/T cg13890972 chr12:28721907 NA -0.39 -6.87 -0.35 3.24e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs9303401 0.659 rs12946852 chr17:57013337 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.12 0.58 5.34e-32 Cognitive test performance; LUSC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg09904177 chr6:26538194 HMGN4 0.42 6.1 0.32 2.86e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg00012203 chr2:219082015 ARPC2 0.74 12.72 0.57 1.65e-30 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs2219968 1.000 rs1073444 chr8:78959671 T/C cg00738934 chr8:78996279 NA 0.34 6.19 0.32 1.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs950169 0.922 rs11630760 chr15:85113337 G/T cg17507749 chr15:85114479 UBE2QP1 0.71 9.38 0.46 1.02e-18 Schizophrenia; LUSC cis rs3096299 0.504 rs4785574 chr16:89568875 A/G cg02187348 chr16:89574699 SPG7 0.53 8.44 0.42 1.01e-15 Multiple myeloma (IgH translocation); LUSC cis rs6696846 0.749 rs6692170 chr1:205074019 G/A cg21545522 chr1:205238299 TMCC2 0.42 8.06 0.4 1.34e-14 Red blood cell count; LUSC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg23791538 chr6:167370224 RNASET2 0.41 6.65 0.34 1.2e-10 Crohn's disease; LUSC cis rs4076764 0.846 rs12035840 chr1:163419177 G/C cg06092702 chr1:163392909 NA -0.4 -6.91 -0.35 2.45e-11 Motion sickness; LUSC cis rs1808579 0.874 rs1367083 chr18:21100240 C/T cg14672496 chr18:21087552 C18orf8 0.4 7.11 0.36 7.23e-12 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs4792901 0.759 rs2271957 chr17:41598940 A/G cg22562494 chr17:41607896 ETV4 -0.32 -6.05 -0.31 3.96e-9 Dupuytren's disease; LUSC cis rs9549367 0.826 rs1885688 chr13:113894236 G/T cg00898013 chr13:113819073 PROZ -0.53 -7.88 -0.4 4.77e-14 Platelet distribution width; LUSC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg16586182 chr3:47516702 SCAP -0.5 -7.98 -0.4 2.45e-14 Colorectal cancer; LUSC cis rs79387448 0.701 rs11465584 chr2:102982629 G/A cg09003973 chr2:102972529 NA 1.21 12.76 0.57 1.2e-30 Gut microbiota (bacterial taxa); LUSC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg13119609 chr19:45449297 APOC2 0.49 10.0 0.48 9.11e-21 Blood protein levels; LUSC cis rs2769264 0.505 rs11801791 chr1:151387508 C/T cg18801370 chr1:151430492 POGZ 0.68 8.29 0.41 2.88e-15 Blood trace element (Cu levels); LUSC cis rs2731664 0.792 rs337374 chr5:176890416 A/G cg23176889 chr5:176863531 GRK6 0.66 13.34 0.59 7.81e-33 Intelligence (multi-trait analysis); LUSC cis rs12618769 0.597 rs72819981 chr2:99040696 T/C cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs7536201 1.000 rs12036815 chr1:25300632 C/T cg23273869 chr1:25296894 NA -0.27 -5.78 -0.3 1.74e-8 Psoriasis vulgaris; LUSC cis rs9341835 0.772 rs9294196 chr6:64135193 A/G cg03326410 chr6:64151739 NA 0.38 6.18 0.32 1.88e-9 Schizophrenia; LUSC cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg17892150 chr10:133769511 PPP2R2D -0.68 -9.46 -0.46 5.56e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg15445000 chr17:37608096 MED1 -0.38 -6.46 -0.33 3.79e-10 Glomerular filtration rate (creatinine); LUSC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.34 0.67 1.6e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14514174 chr9:99181512 ZNF367 -0.39 -6.2 -0.32 1.66e-9 Electrocardiographic conduction measures; LUSC cis rs7677751 0.806 rs73252942 chr4:55104604 T/C cg17187183 chr4:55093834 PDGFRA 0.4 6.11 0.32 2.83e-9 Corneal astigmatism; LUSC cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg03146154 chr1:46216737 IPP 0.54 7.84 0.39 6.19e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.54 8.08 0.4 1.2e-14 Lymphocyte counts; LUSC cis rs7568458 0.811 rs3755015 chr2:85764041 G/A cg02493740 chr2:85810744 VAMP5 -0.38 -6.67 -0.34 1.04e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2067615 0.524 rs754184 chr12:107117521 A/G cg19260189 chr12:106995001 RFX4 0.23 5.8 0.3 1.57e-8 Heart rate; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03183882 chr3:15373315 SH3BP5 -0.48 -6.26 -0.32 1.16e-9 Hepatitis; LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg16145915 chr7:1198662 ZFAND2A -0.46 -8.46 -0.42 8.23e-16 Longevity;Endometriosis; LUSC cis rs9733 0.566 rs878471 chr1:150547747 G/A cg04414720 chr1:150670196 GOLPH3L -0.43 -6.44 -0.33 4.05e-10 Tonsillectomy; LUSC cis rs4280164 0.945 rs4366641 chr14:24771101 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.57 -6.73 -0.35 7.49e-11 Parent of origin effect on language impairment (paternal); LUSC cis rs7408868 1.000 rs7408868 chr19:15285679 G/C cg14696996 chr19:15285081 NOTCH3 0.92 8.92 0.44 3.06e-17 Pulse pressure; LUSC cis rs16976116 0.803 rs9920136 chr15:55504102 A/G cg11288833 chr15:55489084 RSL24D1 0.5 5.95 0.31 6.81e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs56399783 0.901 rs6967664 chr7:2816384 A/G cg14895029 chr7:2775587 GNA12 0.49 5.92 0.31 7.99e-9 Childhood ear infection; LUSC cis rs17270561 0.609 rs4712964 chr6:25740822 A/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.67 0.39 1.91e-13 Iron status biomarkers; LUSC cis rs4423214 0.798 rs1894100 chr11:71130343 G/T cg05163923 chr11:71159392 DHCR7 -0.71 -9.09 -0.45 9.05e-18 Vitamin D levels; LUSC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg24838063 chr12:130822603 PIWIL1 0.69 10.37 0.49 4.84e-22 Menopause (age at onset); LUSC cis rs981844 1.000 rs2405431 chr4:154656396 A/G cg14289246 chr4:154710475 SFRP2 0.5 6.26 0.32 1.2e-9 Response to statins (LDL cholesterol change); LUSC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.19 -0.41 5.46e-15 Personality dimensions; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg13047869 chr3:10149882 C3orf24 0.6 8.42 0.42 1.14e-15 Alzheimer's disease; LUSC cis rs7289126 0.966 rs4820329 chr22:38646063 G/A cg25457927 chr22:38595422 NA -0.29 -5.75 -0.3 1.99e-8 Mammographic density (dense area);Percent mammographic density; LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg20887711 chr4:1340912 KIAA1530 0.56 8.93 0.44 2.9e-17 Longevity; LUSC cis rs73198271 0.515 rs78600128 chr8:8628706 C/A cg01851573 chr8:8652454 MFHAS1 0.61 7.0 0.36 1.39e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs853679 0.607 rs35030260 chr6:28305508 G/A cg06606381 chr12:133084897 FBRSL1 -1.08 -9.45 -0.46 6.26e-19 Depression; LUSC cis rs11018904 0.906 rs61903722 chr11:89967042 C/T cg26028595 chr11:89956573 CHORDC1 -0.52 -6.17 -0.32 2.03e-9 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg17968037 chr7:100024898 ZCWPW1 -0.43 -6.22 -0.32 1.48e-9 Platelet count; LUSC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg22800045 chr5:56110881 MAP3K1 0.44 5.95 0.31 6.73e-9 Coronary artery disease; LUSC cis rs472402 0.580 rs10060745 chr5:6658003 T/C cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.54 -7.76 -0.39 1.02e-13 Response to amphetamines; LUSC cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg26898376 chr11:64110657 CCDC88B 0.33 6.18 0.32 1.85e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs5758659 0.512 rs4822072 chr22:42360833 G/C cg15557168 chr22:42548783 NA -0.36 -5.97 -0.31 6.18e-9 Cognitive function; LUSC cis rs2235649 0.833 rs9929264 chr16:1851934 T/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.43 -5.96 -0.31 6.47e-9 Blood metabolite levels; LUSC cis rs7131987 0.683 rs3782511 chr12:29496224 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -6.96 -0.36 1.8e-11 QT interval; LUSC cis rs11031096 0.782 rs2165728 chr11:4147004 T/C cg18678763 chr11:4115507 RRM1 -0.52 -7.46 -0.38 7.53e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1003719 1.000 rs2835608 chr21:38493455 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.67 10.58 0.5 9.48e-23 Eye color traits; LUSC cis rs9393777 0.778 rs4452638 chr6:27229265 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.52 6.31 0.33 9.05e-10 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg09267113 chr7:98030324 BAIAP2L1 0.4 5.93 0.31 7.51e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 13.46 0.59 2.77e-33 Alzheimer's disease; LUSC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg09365446 chr1:150670422 GOLPH3L 0.48 6.96 0.36 1.81e-11 Melanoma; LUSC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg17385448 chr1:15911702 AGMAT 0.36 6.09 0.32 3.12e-9 Systolic blood pressure; LUSC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg01097406 chr16:89675127 NA -0.34 -6.72 -0.35 7.75e-11 Vitiligo; LUSC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs10207060 0.778 rs6543581 chr2:240702308 C/T cg07506560 chr2:240697449 NA -0.49 -8.18 -0.41 6.08e-15 Obesity-related traits; LUSC cis rs524023 0.914 rs80841 chr11:64437490 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.49 -0.5 1.96e-22 Urate levels in obese individuals; LUSC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg06640241 chr16:89574553 SPG7 0.91 16.34 0.67 1.64e-44 Multiple myeloma (IgH translocation); LUSC cis rs7106204 0.609 rs16912359 chr11:24290818 C/T ch.11.24196551F chr11:24239977 NA 0.7 5.86 0.31 1.1e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1595825 0.735 rs2164327 chr2:198726773 C/T cg10547527 chr2:198650123 BOLL -0.5 -5.91 -0.31 8.58e-9 Ulcerative colitis; LUSC cis rs7582180 0.652 rs12997725 chr2:100935136 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.77 0.3 1.78e-8 Intelligence (multi-trait analysis); LUSC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg13770153 chr20:60521292 NA 1.03 15.48 0.65 3.89e-41 Obesity-related traits; LUSC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg02487422 chr3:49467188 NICN1 0.46 7.12 0.36 6.79e-12 Resting heart rate; LUSC cis rs427394 0.582 rs274665 chr5:6707981 C/T cg10857441 chr5:6722123 POLS -0.43 -7.93 -0.4 3.33e-14 Menopause (age at onset); LUSC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg02772935 chr3:125709198 NA -0.48 -5.79 -0.3 1.63e-8 Blood pressure (smoking interaction); LUSC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.23 0.32 1.42e-9 Height; LUSC trans rs2386661 0.516 rs61832676 chr10:5646337 G/A cg11398623 chr21:37499189 NA 0.27 6.16 0.32 2.11e-9 Breast cancer; LUSC cis rs11190604 1.000 rs2489034 chr10:102319192 C/T cg07080220 chr10:102295463 HIF1AN 0.68 8.73 0.43 1.26e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.37 5.89 0.31 9.21e-9 Primary tooth development (time to first tooth eruption); LUSC trans rs61931739 0.963 rs59195137 chr12:34091838 G/A cg13010199 chr12:38710504 ALG10B -0.4 -6.04 -0.31 4.19e-9 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg21724239 chr8:58056113 NA 0.61 6.68 0.34 1.03e-10 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg13560548 chr3:10150139 C3orf24 0.54 7.12 0.36 6.45e-12 Alzheimer's disease; LUSC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg19901468 chr14:105411992 AHNAK2 -0.71 -12.34 -0.56 4.44e-29 Rheumatoid arthritis; LUSC trans rs1335645 1.000 rs56273250 chr1:111675762 G/A cg26007445 chr17:62287566 TEX2 0.51 6.4 0.33 5.19e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2806561 0.929 rs6669568 chr1:23540469 G/A cg19743168 chr1:23544995 NA -0.46 -10.0 -0.48 9.46e-21 Height; LUSC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11890956 chr21:40555474 PSMG1 0.73 10.94 0.51 5.1900000000000004e-24 Menarche (age at onset); LUSC cis rs59698941 0.943 rs67074969 chr5:132251063 T/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC trans rs6502050 0.835 rs8081949 chr17:80117490 G/A cg07393940 chr7:158741817 NA 0.36 6.43 0.33 4.46e-10 Life satisfaction; LUSC cis rs12928939 0.815 rs11648483 chr16:71707398 T/C cg08717414 chr16:71523259 ZNF19 -0.41 -5.76 -0.3 1.87e-8 Post bronchodilator FEV1; LUSC cis rs62103177 0.535 rs62101568 chr18:77934671 G/A cg20368463 chr18:77673604 PQLC1 0.63 6.28 0.33 1.03e-9 Opioid sensitivity; LUSC cis rs72627509 0.904 rs781663 chr4:57781754 A/G cg26694713 chr4:57773883 REST 0.5 6.12 0.32 2.57e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg00129232 chr17:37814104 STARD3 -0.48 -6.76 -0.35 6.14e-11 Glomerular filtration rate (creatinine); LUSC cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg06064525 chr11:970664 AP2A2 -0.49 -10.93 -0.51 5.64e-24 Alzheimer's disease (late onset); LUSC cis rs11190604 1.000 rs2495736 chr10:102338410 T/C cg16342193 chr10:102329863 NA -0.38 -6.66 -0.34 1.1e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg01448562 chr3:133502909 NA 0.67 10.93 0.51 5.67e-24 Iron status biomarkers; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg02475777 chr4:1388615 CRIPAK 0.37 5.68 0.3 2.96e-8 Obesity-related traits; LUSC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg13628971 chr7:2884303 GNA12 0.5 7.03 0.36 1.17e-11 Height; LUSC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg22437258 chr11:111473054 SIK2 0.53 7.5 0.38 5.65e-13 Primary sclerosing cholangitis; LUSC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg00603274 chr11:61596626 FADS2 -0.58 -8.03 -0.4 1.74e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg22532475 chr10:104410764 TRIM8 -0.34 -7.52 -0.38 4.99e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10769966 0.515 rs2568069 chr11:8977707 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.36 6.47 0.33 3.51e-10 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4268898 0.552 rs4665663 chr2:24372139 G/C cg06627628 chr2:24431161 ITSN2 0.51 7.27 0.37 2.53e-12 Asthma; LUSC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.39 0.42 1.42e-15 Schizophrenia; LUSC cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg15423357 chr2:25149977 NA 0.44 8.91 0.44 3.33e-17 Body mass index; LUSC cis rs1178968 1.000 rs1178969 chr7:72759114 A/G cg25889504 chr7:72793014 NA 0.58 7.49 0.38 6.02e-13 Triglyceride levels; LUSC cis rs7584330 0.740 rs13418586 chr2:238445593 A/G cg16989719 chr2:238392110 NA -0.36 -6.8 -0.35 4.86e-11 Prostate cancer; LUSC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6582630 0.598 rs11182207 chr12:38477514 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.48 -0.33 3.2e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg05855489 chr10:104503620 C10orf26 0.58 9.35 0.46 1.29e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.42 6.75 0.35 6.59e-11 Personality dimensions; LUSC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg11941060 chr3:133502564 NA -0.47 -6.79 -0.35 5.27e-11 Iron status biomarkers; LUSC trans rs1422110 0.543 rs10035841 chr5:85419597 T/C cg01787110 chr1:109008453 NBPF6 0.5 8.97 0.44 2.16e-17 Attention function in attention deficit hyperactive disorder; LUSC cis rs9300255 0.739 rs10846491 chr12:123753492 C/G cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.44 -0.33 4.12e-10 Neutrophil percentage of white cells; LUSC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.83 0.51 1.23e-23 Menopause (age at onset); LUSC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg05855489 chr10:104503620 C10orf26 0.65 9.65 0.47 1.38e-19 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg16434002 chr17:42200994 HDAC5 -0.46 -6.43 -0.33 4.32e-10 Total body bone mineral density; LUSC cis rs6669072 1.000 rs3856228 chr1:91247029 T/G cg08895590 chr1:91227319 NA -0.36 -8.22 -0.41 4.59e-15 Cognitive function; LUSC cis rs4654899 0.865 rs6665549 chr1:21475884 G/C cg01072550 chr1:21505969 NA -0.5 -7.49 -0.38 6.19e-13 Superior frontal gyrus grey matter volume; LUSC cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg07395648 chr5:131743802 NA 0.44 7.13 0.36 6.08e-12 Blood metabolite levels; LUSC cis rs877282 0.853 rs11253332 chr10:755262 G/C cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs7666738 0.519 rs13136069 chr4:98819568 C/T cg17366294 chr4:99064904 C4orf37 0.57 8.75 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs12493885 0.769 rs61791507 chr3:153748886 C/A cg17054900 chr3:154042577 DHX36 -0.67 -7.06 -0.36 9.76e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4851254 0.660 rs10209201 chr2:100672808 C/T cg22139774 chr2:100720529 AFF3 -0.43 -5.71 -0.3 2.55e-8 Intelligence (multi-trait analysis); LUSC trans rs1223397 0.938 rs3817737 chr6:13279082 A/G cg13974761 chr1:152670598 LCE2A 0.36 6.03 0.31 4.31e-9 Blood pressure; LUSC cis rs2835872 0.793 rs2835833 chr21:38987897 A/G cg20424643 chr21:39039972 KCNJ6 -0.37 -5.8 -0.3 1.57e-8 Electroencephalographic traits in alcoholism; LUSC cis rs4595586 0.632 rs1356266 chr12:39403581 A/G cg26384229 chr12:38710491 ALG10B -0.43 -5.96 -0.31 6.26e-9 Morning vs. evening chronotype; LUSC cis rs10979 0.557 rs9376768 chr6:143909492 C/T cg25407410 chr6:143891975 LOC285740 -0.65 -8.3 -0.41 2.65e-15 Hypospadias; LUSC cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg15691649 chr6:25882328 NA -0.38 -6.22 -0.32 1.49e-9 Blood metabolite levels; LUSC cis rs757081 0.667 rs17641418 chr11:17161341 T/C cg15432903 chr11:17409602 KCNJ11 -0.39 -6.04 -0.31 4e-9 Systolic blood pressure; LUSC cis rs870825 0.616 rs61653735 chr4:185630025 G/A cg04058563 chr4:185651563 MLF1IP 0.87 13.12 0.58 5.24e-32 Blood protein levels; LUSC cis rs73001065 0.551 rs10424702 chr19:19508013 A/G cg03709012 chr19:19516395 GATAD2A 0.97 9.18 0.45 4.5e-18 LDL cholesterol; LUSC cis rs1023500 0.551 rs2854837 chr22:42458481 G/A cg15557168 chr22:42548783 NA -0.38 -5.76 -0.3 1.93e-8 Schizophrenia; LUSC cis rs10140922 0.966 rs10083375 chr14:35823531 C/T cg07166546 chr14:35805898 NA -0.26 -6.4 -0.33 5.37e-10 Hip circumference adjusted for BMI; LUSC trans rs9929218 1.000 rs35069703 chr16:68789445 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -11.95 -0.55 1.23e-27 Colorectal cancer; LUSC cis rs4499344 0.504 rs259248 chr19:33148041 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.7 10.44 0.5 2.84e-22 Mean platelet volume; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg01879757 chr17:41196368 BRCA1 -0.45 -6.85 -0.35 3.63e-11 Menopause (age at onset); LUSC cis rs10435719 0.834 rs6985792 chr8:11795335 T/C cg21775007 chr8:11205619 TDH 0.47 6.69 0.34 9.25e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg13390004 chr1:15929781 NA 0.41 6.76 0.35 6.35e-11 Systolic blood pressure; LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs7937682 0.889 rs521155 chr11:111492563 G/A cg18187862 chr3:45730750 SACM1L 0.53 7.03 0.36 1.16e-11 Primary sclerosing cholangitis; LUSC cis rs73206853 0.841 rs73206882 chr12:110840515 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs72634258 0.945 rs17523802 chr1:8021740 G/A cg00042356 chr1:8021962 PARK7 0.85 10.4 0.49 3.8e-22 Inflammatory bowel disease; LUSC cis rs9902453 0.935 rs9909093 chr17:28271207 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.79 0.51 1.7e-23 Coffee consumption (cups per day); LUSC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs9443645 0.527 rs9343870 chr6:79789473 T/G cg05283184 chr6:79620031 NA -0.46 -8.73 -0.43 1.21e-16 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg06784218 chr1:46089804 CCDC17 -0.51 -10.05 -0.48 6.2e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg17515076 chr17:73810948 UNK 0.35 5.99 0.31 5.29e-9 White matter hyperintensity burden; LUSC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg12288994 chr5:1860383 NA 0.29 6.42 0.33 4.77e-10 Cardiovascular disease risk factors; LUSC cis rs1595825 0.945 rs61184128 chr2:198843659 C/T cg00982548 chr2:198649783 BOLL -0.57 -7.13 -0.36 6.43e-12 Ulcerative colitis; LUSC trans rs11098499 0.913 rs10010696 chr4:120164303 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 5.99 0.31 5.35e-9 Corneal astigmatism; LUSC trans rs853679 0.607 rs13194781 chr6:27815639 A/G cg06606381 chr12:133084897 FBRSL1 -1.02 -9.08 -0.44 9.93e-18 Depression; LUSC cis rs4776059 0.550 rs8032394 chr15:52868032 G/A cg22715398 chr15:52968154 KIAA1370 -0.57 -6.71 -0.34 8.48e-11 Schizophrenia; LUSC cis rs3820928 1.000 rs10210763 chr2:227776029 G/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.85 -0.39 5.89e-14 Pulmonary function; LUSC trans rs7786808 0.707 rs62479983 chr7:158227613 G/A cg02030672 chr11:45687055 CHST1 0.43 6.49 0.33 3.18e-10 Obesity-related traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17823076 chr12:53574937 ZNF740;CSAD -0.52 -6.99 -0.36 1.51e-11 Bipolar disorder and schizophrenia; LUSC cis rs911119 0.955 rs8121283 chr20:23605002 G/C cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC cis rs80282103 0.867 rs7075830 chr10:1091650 G/C cg08668510 chr10:1095578 IDI1 0.74 6.62 0.34 1.47e-10 Glomerular filtration rate (creatinine); LUSC cis rs6546886 0.912 rs13387010 chr2:74294654 A/G cg14702570 chr2:74259524 NA -0.31 -5.83 -0.3 1.33e-8 Dialysis-related mortality; LUSC cis rs6484504 0.576 rs208072 chr11:31141288 A/G cg14844989 chr11:31128820 NA 0.37 5.77 0.3 1.81e-8 Red blood cell count; LUSC trans rs7824557 0.564 rs2437152 chr8:11235497 G/A cg15556689 chr8:8085844 FLJ10661 -0.49 -7.53 -0.38 4.91e-13 Retinal vascular caliber; LUSC cis rs1507153 0.614 rs236882 chr6:79316113 A/G cg05283184 chr6:79620031 NA 0.38 7.0 0.36 1.37e-11 Sjögren's syndrome; LUSC cis rs983392 0.709 rs7928895 chr11:59975165 G/A cg20284999 chr11:59952153 MS4A6A -0.38 -6.28 -0.32 1.06e-9 Alzheimer's disease (late onset); LUSC cis rs10203711 0.673 rs9677610 chr2:239621531 G/A cg14580085 chr2:239553406 NA 0.42 6.98 0.36 1.61e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs8016982 0.698 rs8021385 chr14:81704682 G/A cg01989461 chr14:81687754 GTF2A1 0.66 10.93 0.51 5.5e-24 Schizophrenia; LUSC cis rs911555 0.539 rs4374097 chr14:104072766 A/C cg24130564 chr14:104152367 KLC1 -0.73 -11.75 -0.54 6.45e-27 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.47 6.8 0.35 4.74e-11 Menarche (age at onset); LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg25719132 chr2:70520671 SNRPG 0.43 6.84 0.35 3.69e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs16937 0.711 rs4333898 chr1:205169613 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.54 0.34 2.36e-10 Schizophrenia; LUSC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg04369109 chr6:150039330 LATS1 -0.55 -8.2 -0.41 5.09e-15 Lung cancer; LUSC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg17211192 chr8:82754475 SNX16 -0.78 -10.68 -0.5 4.1000000000000003e-23 Diastolic blood pressure; LUSC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg15445000 chr17:37608096 MED1 -0.4 -6.79 -0.35 5.25e-11 Glomerular filtration rate (creatinine); LUSC cis rs8014204 1.000 rs10483863 chr14:75322327 A/G cg06637938 chr14:75390232 RPS6KL1 -0.65 -10.87 -0.51 9.03e-24 Caffeine consumption; LUSC cis rs9395066 0.545 rs12525009 chr6:44875843 C/T cg25276700 chr6:44698697 NA 0.3 5.99 0.31 5.45e-9 Height; LUSC trans rs11751618 0.532 rs9450467 chr6:87193382 T/C cg10525134 chr8:58191969 C8orf71 0.43 6.03 0.31 4.36e-9 Gut microbiome composition (winter); LUSC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg24110177 chr3:50126178 RBM5 -0.6 -9.73 -0.47 7.5599999999999994e-20 Intelligence (multi-trait analysis); LUSC cis rs5750830 0.594 rs9611166 chr22:39775268 T/C cg05872129 chr22:39784769 NA -0.59 -10.78 -0.51 1.82e-23 Intelligence (multi-trait analysis); LUSC trans rs72674100 1.000 rs72882341 chr4:97993768 G/C cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6690583 0.623 rs75918067 chr1:85453413 T/C cg22153463 chr1:85462885 MCOLN2 0.62 6.0 0.31 5.12e-9 Serum sulfate level; LUSC cis rs12950390 0.853 rs11079791 chr17:45859099 C/T cg03474202 chr17:45855739 NA -0.29 -6.83 -0.35 4.06e-11 IgG glycosylation; LUSC trans rs61931739 0.500 rs3924704 chr12:34557833 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.37 0.64 1.04e-40 Morning vs. evening chronotype; LUSC cis rs7589342 0.862 rs6745887 chr2:106468039 G/A cg14210321 chr2:106509881 NCK2 -0.5 -7.26 -0.37 2.75e-12 Addiction; LUSC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.62 -8.93 -0.44 2.9e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs61990749 0.597 rs11623088 chr14:78137735 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.41 -0.33 4.99e-10 Fibroblast growth factor basic levels; LUSC cis rs28595532 0.623 rs34284204 chr4:119227672 C/T cg21605333 chr4:119757512 SEC24D 0.73 6.13 0.32 2.46e-9 Cannabis dependence symptom count; LUSC cis rs7408868 0.908 rs10416865 chr19:15277601 T/C cg14696996 chr19:15285081 NOTCH3 0.96 9.25 0.45 2.69e-18 Pulse pressure; LUSC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11890956 chr21:40555474 PSMG1 -0.91 -15.95 -0.66 5.46e-43 Cognitive function; LUSC trans rs62103177 0.673 rs4438371 chr18:77615988 C/T cg14227996 chr4:17616232 MED28 0.57 6.4 0.33 5.22e-10 Opioid sensitivity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21721210 chr19:39574878 PAPL -0.44 -6.01 -0.31 4.94e-9 Bipolar disorder and schizophrenia; LUSC trans rs417096 0.929 rs455396 chr6:39734557 A/G cg17457912 chr17:1617102 C17orf91 -0.33 -6.4 -0.33 5.3e-10 Hypospadias; LUSC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs12980942 1.000 rs12984160 chr19:41815713 A/G cg25627403 chr19:41769009 HNRNPUL1 0.57 6.16 0.32 2.05e-9 Coronary artery disease; LUSC cis rs9378688 0.654 rs2505659 chr6:2326637 G/A cg12303981 chr6:2244766 GMDS -0.44 -6.12 -0.32 2.61e-9 Caudate nucleus volume; LUSC cis rs10927875 0.578 rs10927859 chr1:16141862 C/T cg22431228 chr1:16359049 CLCNKA 0.32 5.84 0.3 1.23e-8 Dilated cardiomyopathy; LUSC cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg26384229 chr12:38710491 ALG10B 0.91 15.54 0.65 2.38e-41 Bladder cancer; LUSC cis rs6076065 0.723 rs6137908 chr20:23344590 G/A cg11657817 chr20:23433608 CST11 0.44 8.18 0.41 6.2e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs929354 0.772 rs933344 chr7:157011265 A/T cg05182265 chr7:156933206 UBE3C -0.6 -9.78 -0.47 4.89e-20 Body mass index; LUSC cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.72e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs9291683 0.610 rs993172 chr4:10324361 G/T cg26043149 chr18:55253948 FECH 0.56 8.79 0.43 8.09e-17 Bone mineral density; LUSC cis rs12200560 0.505 rs984519 chr6:97076223 A/G cg06623918 chr6:96969491 KIAA0776 -0.5 -7.41 -0.38 1.03e-12 Coronary heart disease; LUSC trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg15704280 chr7:45808275 SEPT13 0.93 13.42 0.59 3.7e-33 Coronary artery disease; LUSC trans rs57221529 0.766 rs72706608 chr5:559203 C/T cg11887960 chr12:57824829 NA 0.55 7.21 0.37 3.7e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg23262073 chr20:60523788 NA -0.39 -5.95 -0.31 6.89e-9 Body mass index; LUSC trans rs61931739 0.517 rs12815556 chr12:34319670 G/A cg13010199 chr12:38710504 ALG10B 0.54 8.45 0.42 9.36e-16 Morning vs. evening chronotype; LUSC cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg06627628 chr2:24431161 ITSN2 -0.59 -7.16 -0.36 5.28e-12 Lymphocyte counts; LUSC cis rs66887589 0.967 rs2892869 chr4:120521297 T/C cg24375607 chr4:120327624 NA -0.47 -7.32 -0.37 1.85e-12 Diastolic blood pressure; LUSC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg13683864 chr3:40499215 RPL14 1.12 19.99 0.74 5.25e-59 Renal cell carcinoma; LUSC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg26727032 chr16:67993705 SLC12A4 -0.44 -5.88 -0.31 9.79e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9400467 0.528 rs11153292 chr6:111722379 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.98 -0.36 1.56e-11 Blood metabolite levels;Amino acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07117119 chr16:68119705 NFATC3 -0.46 -7.09 -0.36 8.23e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7584330 0.910 rs72620830 chr2:238396985 C/T cg14458575 chr2:238380390 NA 0.71 12.4 0.56 2.54e-29 Prostate cancer; LUSC cis rs721399 0.719 rs12674710 chr8:18263663 A/C cg18736775 chr8:18248649 NAT2 -0.56 -6.94 -0.36 2e-11 Blood metabolite levels; LUSC cis rs377070 0.934 rs309411 chr4:123620150 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.45 6.67 0.34 1.05e-10 Mosquito bite size; LUSC cis rs524023 0.915 rs531763 chr11:64352063 A/G cg07220939 chr11:64358617 SLC22A12 0.23 5.9 0.31 8.69e-9 Urate levels in obese individuals; LUSC cis rs6500395 1.000 rs1420704 chr16:48716902 C/T cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg24558204 chr6:135376177 HBS1L 0.68 10.82 0.51 1.32e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg00152838 chr16:24741724 TNRC6A -0.46 -5.69 -0.3 2.74e-8 Intelligence (multi-trait analysis); LUSC cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg24812749 chr6:127587940 RNF146 0.91 13.5 0.59 1.98e-33 Breast cancer; LUSC cis rs1348850 1.000 rs3927978 chr2:178443854 A/G cg22681709 chr2:178499509 PDE11A 0.46 8.49 0.42 6.84e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4666002 0.956 rs10169065 chr2:27778560 A/G cg27432699 chr2:27873401 GPN1 0.41 5.7 0.3 2.69e-8 Phospholipid levels (plasma); LUSC cis rs611744 0.647 rs2594357 chr8:109255989 A/G cg21045802 chr8:109455806 TTC35 0.42 6.56 0.34 2.1e-10 Dupuytren's disease; LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg08470875 chr2:26401718 FAM59B -0.66 -8.99 -0.44 1.91e-17 Gut microbiome composition (summer); LUSC cis rs1014246 0.807 rs10886003 chr10:118461226 G/A cg14919929 chr10:118506882 NA 0.47 7.24 0.37 3.19e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12195820 chr8:42698243 THAP1 0.44 6.63 0.34 1.36e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9733 0.566 rs878471 chr1:150547747 G/A cg09365446 chr1:150670422 GOLPH3L -0.42 -6.12 -0.32 2.56e-9 Tonsillectomy; LUSC cis rs950169 0.922 rs12912934 chr15:85114447 C/T cg17507749 chr15:85114479 UBE2QP1 0.71 9.36 0.46 1.2e-18 Schizophrenia; LUSC trans rs60843830 1.000 rs62114548 chr2:274672 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.37 0.49 4.82e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1014246 0.784 rs4751610 chr10:118473730 T/C cg14919929 chr10:118506882 NA -0.42 -6.71 -0.34 8.24e-11 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg09365446 chr1:150670422 GOLPH3L 0.49 7.22 0.37 3.63e-12 Melanoma; LUSC cis rs72781680 1.000 rs7581107 chr2:24173565 C/T cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs1670533 1.000 rs4690215 chr4:1054619 G/C cg27284194 chr4:1044797 NA 0.59 8.8 0.43 7.59e-17 Recombination rate (females); LUSC cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg01849466 chr14:104193079 ZFYVE21 -0.47 -7.18 -0.37 4.48e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs3858526 0.834 rs6578712 chr11:5987071 C/T cg25319279 chr11:5960081 NA -0.45 -6.25 -0.32 1.24e-9 DNA methylation (variation); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13411962 chr8:28243934 ZNF395 -0.54 -6.41 -0.33 5.03e-10 Bipolar disorder and schizophrenia; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02018176 chr4:1364513 KIAA1530 0.74 14.1 0.61 9.53e-36 Longevity; LUSC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg00933542 chr6:150070202 PCMT1 0.32 6.7 0.34 8.68e-11 Lung cancer; LUSC trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs8114671 0.836 rs6142284 chr20:33641367 G/A cg24642439 chr20:33292090 TP53INP2 -0.39 -5.67 -0.3 3.14e-8 Height; LUSC cis rs2637266 0.967 rs12254242 chr10:78352934 T/C cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC trans rs5747327 0.557 rs2895951 chr22:18232368 C/T cg13083436 chr11:24518414 LUZP2 0.31 5.96 0.31 6.5e-9 Myeloid white cell count;Granulocyte count; LUSC cis rs9653442 0.900 rs2309837 chr2:100837567 T/C cg07810366 chr2:100720526 AFF3 -0.47 -8.03 -0.4 1.68e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.59 -0.34 1.69e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.95 0.31 6.76e-9 Self-reported allergy; LUSC cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg27446573 chr6:127587934 RNF146 0.8 12.79 0.57 9.2e-31 Breast cancer; LUSC cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg05768032 chr16:30646687 NA 0.38 5.67 0.3 3.07e-8 Multiple myeloma; LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg26314531 chr2:26401878 FAM59B -0.71 -10.02 -0.48 7.96e-21 Gut microbiome composition (summer); LUSC cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg23711669 chr6:146136114 FBXO30 0.73 12.89 0.58 3.92e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs2348418 0.715 rs12307612 chr12:28719646 C/T cg13890972 chr12:28721907 NA -0.39 -6.87 -0.35 3.24e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg06640241 chr16:89574553 SPG7 0.89 16.03 0.66 2.65e-43 Multiple myeloma (IgH translocation); LUSC cis rs478304 0.627 rs1073602 chr11:65455386 G/C cg05805236 chr11:65401703 PCNXL3 -0.63 -10.33 -0.49 6.71e-22 Acne (severe); LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg03354898 chr7:1950403 MAD1L1 -0.42 -8.57 -0.42 3.93e-16 Bipolar disorder and schizophrenia; LUSC cis rs941408 1.000 rs1640271 chr19:2799979 C/T cg06609049 chr19:2785107 THOP1 0.68 11.06 0.52 2e-24 Total cholesterol levels; LUSC cis rs4629180 0.675 rs6707298 chr2:102089738 A/G cg04415270 chr2:102091202 RFX8 0.46 7.99 0.4 2.27e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7582720 1.000 rs6723704 chr2:203738664 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs1927790 0.759 rs12585563 chr13:96991847 A/G cg03198741 chr6:1003969 LOC285768 -0.4 -5.97 -0.31 5.97e-9 Body mass index; LUSC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg06008330 chr7:65541103 ASL 0.4 6.21 0.32 1.57e-9 Aortic root size; LUSC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg17724175 chr1:150552817 MCL1 0.37 6.57 0.34 1.95e-10 Tonsillectomy; LUSC cis rs8078723 0.668 rs4239225 chr17:38127112 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.51 -8.47 -0.42 7.66e-16 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg06544989 chr22:39130855 UNC84B 0.38 6.77 0.35 5.8200000000000003e-11 Menopause (age at onset); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08052428 chr9:135996421 RALGDS 0.43 6.14 0.32 2.29e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg11062466 chr8:58055876 NA 0.66 8.56 0.42 4.33e-16 Developmental language disorder (linguistic errors); LUSC cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg24692254 chr21:30365293 RNF160 -0.54 -7.86 -0.4 5.38e-14 Dental caries; LUSC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg20135002 chr11:47629003 NA -0.51 -8.14 -0.41 8.16e-15 Subjective well-being; LUSC cis rs6893300 0.524 rs12374446 chr5:179131143 A/G cg14593053 chr5:179126677 CANX 0.48 7.43 0.38 9.08e-13 Resting heart rate; LUSC cis rs514406 0.767 rs551591 chr1:53301876 A/G cg22166914 chr1:53195759 ZYG11B 0.52 8.64 0.43 2.29e-16 Monocyte count; LUSC cis rs4474465 0.850 rs10751292 chr11:78242201 C/G cg27205649 chr11:78285834 NARS2 0.54 6.39 0.33 5.5e-10 Alzheimer's disease (survival time); LUSC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg04155289 chr7:94953770 PON1 -0.36 -5.96 -0.31 6.54e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6542838 0.609 rs13028500 chr2:99528296 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.56 -0.34 2.1e-10 Fear of minor pain; LUSC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg04719120 chr6:96025338 MANEA 0.46 5.78 0.3 1.72e-8 Behavioural disinhibition (generation interaction); LUSC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg00166722 chr3:10149974 C3orf24 0.55 7.54 0.38 4.57e-13 Alzheimer's disease; LUSC cis rs11209002 0.522 rs2224502 chr1:67539439 A/G cg02640540 chr1:67518911 SLC35D1 0.62 8.53 0.42 5.27e-16 Crohn's disease; LUSC cis rs7909074 1.000 rs7079573 chr10:45400406 G/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.71 -0.43 1.4e-16 Mean corpuscular volume; LUSC cis rs12893668 0.703 rs7148456 chr14:104028270 C/T cg04998671 chr14:104000505 TRMT61A 0.43 6.18 0.32 1.83e-9 Reticulocyte count; LUSC trans rs7937682 1.000 rs7121011 chr11:111568681 C/T cg18187862 chr3:45730750 SACM1L -0.55 -6.78 -0.35 5.52e-11 Primary sclerosing cholangitis; LUSC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.58 8.0 0.4 2.05e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7927592 0.913 rs948316 chr11:68309670 G/T cg16797656 chr11:68205561 LRP5 0.38 6.22 0.32 1.47e-9 Total body bone mineral density; LUSC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg08270630 chr22:50330655 NA -0.61 -7.72 -0.39 1.37e-13 Schizophrenia; LUSC cis rs240764 0.817 rs239201 chr6:101123993 T/A cg09795085 chr6:101329169 ASCC3 0.42 6.11 0.32 2.83e-9 Neuroticism; LUSC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg02574844 chr11:5959923 NA -0.46 -7.47 -0.38 6.95e-13 DNA methylation (variation); LUSC cis rs3099143 1.000 rs3099137 chr15:77123626 G/A cg21673338 chr15:77095150 SCAPER -0.81 -7.62 -0.38 2.59e-13 Recalcitrant atopic dermatitis; LUSC cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg04034577 chr2:241836375 C2orf54 -0.48 -8.93 -0.44 2.94e-17 Urinary metabolites; LUSC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg03213289 chr20:61660250 NA 0.67 13.65 0.6 5.25e-34 Prostate cancer (SNP x SNP interaction); LUSC cis rs2797160 1.000 rs6933471 chr6:126017029 T/G cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.96e-16 Endometrial cancer; LUSC cis rs7089973 0.668 rs10885622 chr10:116643844 C/T cg25233709 chr10:116636983 FAM160B1 0.39 6.66 0.34 1.14e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4665809 0.652 rs2384360 chr2:26405016 C/G cg25036284 chr2:26402008 FAM59B -0.74 -10.51 -0.5 1.66e-22 Gut microbiome composition (summer); LUSC cis rs9527 0.590 rs10786738 chr10:104869451 C/T cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg16230307 chr14:35515116 FAM177A1 0.5 6.37 0.33 6.28e-10 Psoriasis; LUSC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg18876405 chr7:65276391 NA 0.54 8.23 0.41 4.27e-15 Aortic root size; LUSC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.04 0.31 4.1e-9 Schizophrenia; LUSC cis rs12579753 0.810 rs1922565 chr12:82135348 T/C cg21231944 chr12:82153410 PPFIA2 -0.39 -6.05 -0.31 3.84e-9 Resting heart rate; LUSC cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg00071950 chr4:10020882 SLC2A9 -0.52 -8.85 -0.44 5.12e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2742234 0.578 rs2435354 chr10:43652445 C/T cg15436174 chr10:43711423 RASGEF1A -0.42 -7.06 -0.36 9.54e-12 Hirschsprung disease; LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg03538708 chr1:25844672 NA -0.35 -5.76 -0.3 1.9e-8 Erythrocyte sedimentation rate; LUSC cis rs35883536 0.967 rs2050471 chr1:101175651 C/T cg06223162 chr1:101003688 GPR88 0.32 5.85 0.3 1.17e-8 Monocyte count; LUSC trans rs7824557 0.628 rs3174048 chr8:11184937 G/A cg15556689 chr8:8085844 FLJ10661 0.45 6.7 0.34 9.03e-11 Retinal vascular caliber; LUSC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg14403583 chr14:105418241 AHNAK2 0.56 9.32 0.45 1.67e-18 Rheumatoid arthritis; LUSC cis rs17095355 1.000 rs734165 chr10:111697789 C/T cg00817464 chr10:111662876 XPNPEP1 -0.65 -7.81 -0.39 7.6e-14 Biliary atresia; LUSC cis rs17021463 0.902 rs2016483 chr4:95229039 A/T cg11021082 chr4:95130006 SMARCAD1 -0.42 -7.7 -0.39 1.5700000000000001e-13 Testicular germ cell tumor; LUSC cis rs11785400 1.000 rs11780221 chr8:143748215 T/A cg24634471 chr8:143751801 JRK 0.58 8.75 0.43 1.07e-16 Schizophrenia; LUSC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg22875332 chr1:76189707 ACADM 0.84 15.42 0.64 6.99e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg07148914 chr20:33460835 GGT7 -0.52 -8.1 -0.41 1.02e-14 Glomerular filtration rate (creatinine); LUSC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs6733011 0.578 rs12468024 chr2:99495980 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.98 -0.36 1.57e-11 Bipolar disorder; LUSC cis rs7944584 0.611 rs10838696 chr11:47363285 A/G cg20307385 chr11:47447363 PSMC3 -0.75 -11.64 -0.54 1.58e-26 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs6429082 0.521 rs291390 chr1:235649678 T/C cg26050004 chr1:235667680 B3GALNT2 0.8 13.86 0.6 8.36e-35 Adiposity; LUSC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg06108461 chr20:60628389 TAF4 -1.01 -17.07 -0.68 2.08e-47 Body mass index; LUSC cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg24690094 chr11:67383802 NA 0.44 8.21 0.41 4.77e-15 Mean corpuscular volume; LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg01516881 chr6:292596 DUSP22 -0.51 -7.19 -0.37 4.31e-12 Menopause (age at onset); LUSC cis rs921943 0.554 rs163132 chr5:78285921 A/G cg04677158 chr5:78279841 ARSB -0.46 -7.16 -0.36 5.11e-12 Blood and toenail selenium levels;Blood trace element (Se levels); LUSC cis rs7538876 0.935 rs11577822 chr1:17754608 T/G cg07965774 chr1:17746286 RCC2 0.31 5.83 0.3 1.34e-8 Basal cell carcinoma; LUSC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg21951975 chr1:209979733 IRF6 0.58 7.61 0.38 2.76e-13 Cleft lip with or without cleft palate; LUSC cis rs10489202 0.608 rs16828093 chr1:168078384 C/T cg24449463 chr1:168025552 DCAF6 -0.63 -9.66 -0.47 1.27e-19 Schizophrenia; LUSC cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.18 0.45 4.54e-18 Motion sickness; LUSC cis rs11098499 0.863 rs1552092 chr4:120488496 C/T cg09307838 chr4:120376055 NA 0.75 10.74 0.51 2.58e-23 Corneal astigmatism; LUSC cis rs7113850 0.541 rs4451727 chr11:24216855 G/C ch.11.24196551F chr11:24239977 NA 0.96 8.77 0.43 9.54e-17 Bone fracture in osteoporosis; LUSC cis rs8062405 1.000 rs62036617 chr16:28827498 T/C cg09754948 chr16:28834200 ATXN2L 0.44 6.43 0.33 4.51e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs8017423 0.967 rs55894943 chr14:90714799 A/G cg14092571 chr14:90743983 NA -0.35 -5.68 -0.3 2.89e-8 Mortality in heart failure; LUSC cis rs6582630 0.512 rs11182667 chr12:38588392 C/A cg26384229 chr12:38710491 ALG10B -0.56 -8.45 -0.42 9.13e-16 Drug-induced liver injury (flucloxacillin); LUSC trans rs61931739 0.500 rs11053273 chr12:34547255 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC trans rs7939886 0.920 rs12223248 chr11:55887633 A/C cg03929089 chr4:120376271 NA 0.75 6.17 0.32 2.02e-9 Myopia (pathological); LUSC trans rs2262909 0.962 rs73019844 chr19:22249925 T/C cg05197062 chr11:11642011 GALNTL4 0.56 7.88 0.4 4.75e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7605827 0.930 rs6750232 chr2:15714958 C/T cg19274914 chr2:15703543 NA 0.46 8.9 0.44 3.68e-17 Educational attainment (years of education); LUSC cis rs981844 0.775 rs17371336 chr4:154749525 A/G cg14289246 chr4:154710475 SFRP2 0.48 6.43 0.33 4.46e-10 Response to statins (LDL cholesterol change); LUSC cis rs9640161 0.617 rs73170169 chr7:150008036 G/A cg17279839 chr7:150038598 RARRES2 0.49 7.49 0.38 6.18e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs12542260 0.817 rs117952028 chr8:125471390 C/A cg27038428 chr8:125485867 RNF139 0.33 6.66 0.34 1.15e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.94 0.31 7.17e-9 Menopause (age at onset); LUSC cis rs11122272 0.735 rs2486740 chr1:231517552 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs11997175 0.572 rs7836230 chr8:33623250 T/C ch.8.33884649F chr8:33765107 NA 0.51 8.15 0.41 7.39e-15 Body mass index; LUSC cis rs2348418 0.864 rs7295120 chr12:28718108 C/A cg13890972 chr12:28721907 NA -0.34 -5.92 -0.31 7.94e-9 Lung function (FVC);Lung function (FEV1); LUSC trans rs8073060 0.586 rs35542792 chr17:33903886 A/G cg19694781 chr19:47549865 TMEM160 1.12 18.02 0.7 3.55e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs561341 0.709 rs8068049 chr17:30183857 T/C cg27661571 chr11:113659931 NA 0.67 6.6 0.34 1.59e-10 Hip circumference adjusted for BMI; LUSC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg20203395 chr5:56204925 C5orf35 0.46 6.83 0.35 4.09e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs765787 0.530 rs1706831 chr15:45516230 T/C cg25801113 chr15:45476975 SHF 0.34 7.0 0.36 1.37e-11 Uric acid levels; LUSC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg07701084 chr6:150067640 NUP43 0.54 8.09 0.4 1.12e-14 Lung cancer; LUSC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs227833 0.955 rs227836 chr6:44682740 C/G cg20913747 chr6:44695427 NA 0.38 5.75 0.3 1.98e-8 Monobrow; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg11494091 chr17:61959527 GH2 0.64 13.57 0.6 1e-33 Prudent dietary pattern; LUSC cis rs17095355 1.000 rs12242642 chr10:111724213 G/A cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.49 -0.38 6.22e-13 Biliary atresia; LUSC cis rs11051970 0.553 rs325419 chr12:32572460 A/G cg02745156 chr12:32552066 NA 0.38 6.9 0.35 2.67e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs35110281 0.720 rs162393 chr21:44942692 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 11.35 0.53 1.86e-25 Mean corpuscular volume; LUSC trans rs7726839 0.574 rs72705017 chr5:623733 G/A cg25482853 chr8:67687455 SGK3 1.1 15.29 0.64 2.28e-40 Obesity-related traits; LUSC cis rs4919687 0.550 rs11191372 chr10:104462187 T/C cg04362960 chr10:104952993 NT5C2 0.47 6.85 0.35 3.52e-11 Colorectal cancer; LUSC trans rs7615952 0.673 rs7632557 chr3:125634881 G/C cg07211511 chr3:129823064 LOC729375 -1.24 -18.99 -0.72 4.75e-55 Blood pressure (smoking interaction); LUSC cis rs17270561 0.666 rs3923725 chr6:25734920 C/A cg17691542 chr6:26056736 HIST1H1C 0.57 7.77 0.39 9.81e-14 Iron status biomarkers; LUSC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg22029157 chr1:209979665 IRF6 0.74 10.99 0.52 3.49e-24 Cleft lip with or without cleft palate; LUSC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg12463550 chr7:65579703 CRCP -0.47 -7.1 -0.36 7.5e-12 Aortic root size; LUSC cis rs6546537 0.826 rs2704443 chr2:69889338 A/C cg10773587 chr2:69614142 GFPT1 -0.53 -8.12 -0.41 9.2e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg01570182 chr17:44337453 NA 0.7 10.59 0.5 8.79e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6121246 0.567 rs6058187 chr20:30190923 T/C cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC trans rs7980799 0.618 rs1482983 chr12:33690326 A/C cg13010199 chr12:38710504 ALG10B 0.43 6.2 0.32 1.62e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T ch.13.721274R chr13:51955414 INTS6 -0.4 -6.2 -0.32 1.62e-9 Leprosy; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03576123 chr11:487126 PTDSS2 -1.12 -11.87 -0.54 2.31e-27 Body mass index; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg04775059 chr7:64541387 NA 0.53 7.7 0.39 1.54e-13 Calcium levels; LUSC cis rs9287719 1.000 rs9679122 chr2:10751710 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC trans rs11098499 0.909 rs28793658 chr4:120307214 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.09 0.32 3.12e-9 Corneal astigmatism; LUSC cis rs662064 0.962 rs2506901 chr1:10563492 A/G cg20482658 chr1:10539492 PEX14 0.33 6.74 0.35 6.98e-11 Asthma; LUSC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.52 0.38 4.99e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4704187 0.640 rs1600075 chr5:74418304 G/A cg03227963 chr5:74354835 NA 0.32 6.81 0.35 4.62e-11 Response to amphetamines; LUSC cis rs16958440 0.708 rs57468764 chr18:44624856 T/C cg17192377 chr18:44677553 HDHD2 0.43 5.67 0.3 3.06e-8 Sitting height ratio; LUSC cis rs2658782 0.654 rs2605622 chr11:93248242 A/G cg15737290 chr11:93063684 CCDC67 0.61 7.65 0.39 2.18e-13 Pulmonary function decline; LUSC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC trans rs853679 0.607 rs71559070 chr6:28038929 G/A cg01620082 chr3:125678407 NA -0.87 -7.72 -0.39 1.34e-13 Depression; LUSC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg06740227 chr12:86229804 RASSF9 0.45 7.15 0.36 5.35e-12 Major depressive disorder; LUSC cis rs7000551 0.532 rs55726237 chr8:22252985 C/T cg12081754 chr8:22256438 SLC39A14 0.97 15.29 0.64 2.15e-40 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg00071950 chr4:10020882 SLC2A9 0.53 8.5 0.42 6.22e-16 Bone mineral density; LUSC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg04025307 chr7:1156635 C7orf50 0.43 6.26 0.32 1.21e-9 Bronchopulmonary dysplasia; LUSC cis rs2073300 0.609 rs2281428 chr20:23400050 C/T cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4889855 0.556 rs4278795 chr17:78533189 A/T cg16591659 chr17:78472290 NA 0.32 6.14 0.32 2.39e-9 Fractional excretion of uric acid; LUSC cis rs9653442 0.510 rs11891046 chr2:100794402 C/G cg07810366 chr2:100720526 AFF3 -0.42 -7.18 -0.37 4.46e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs350251 0.524 rs350250 chr16:12202524 C/G cg00459119 chr16:12172834 SNX29 -0.37 -6.06 -0.31 3.71e-9 Intelligence (multi-trait analysis); LUSC cis rs921968 0.607 rs2465100 chr2:219551044 A/T cg02176678 chr2:219576539 TTLL4 -0.59 -10.42 -0.5 3.24e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg27094323 chr7:1216898 NA -0.39 -6.65 -0.34 1.21e-10 Longevity;Endometriosis; LUSC cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg08807101 chr21:30365312 RNF160 -0.76 -13.6 -0.6 7.84e-34 Dental caries; LUSC cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.94 -0.36 2.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.53e-12 Motion sickness; LUSC cis rs17401966 0.867 rs10492973 chr1:10398985 T/C cg19773385 chr1:10388646 KIF1B -0.49 -8.54 -0.42 4.68e-16 Hepatocellular carcinoma; LUSC trans rs34421088 0.576 rs2572437 chr8:11098441 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -5.95 -0.31 6.67e-9 Neuroticism; LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC cis rs2204008 0.538 rs61931093 chr12:38242911 C/T cg13010199 chr12:38710504 ALG10B -0.46 -6.93 -0.35 2.18e-11 Bladder cancer; LUSC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.65 0.5 5.52e-23 Homoarginine levels; LUSC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg25036284 chr2:26402008 FAM59B -0.67 -9.38 -0.46 1.08e-18 Gut microbiome composition (summer); LUSC cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg08045932 chr20:61659980 NA 0.55 9.23 0.45 3.17e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.94 -0.31 7.1e-9 Lung cancer; LUSC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg22875332 chr1:76189707 ACADM 0.86 14.12 0.61 7.7e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg25036284 chr2:26402008 FAM59B -0.71 -10.34 -0.49 6.12e-22 Gut microbiome composition (summer); LUSC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg05368731 chr17:41323189 NBR1 0.92 15.35 0.64 1.26e-40 Menopause (age at onset); LUSC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg25019033 chr10:957182 NA -0.53 -6.93 -0.35 2.15e-11 Eosinophil percentage of granulocytes; LUSC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg02159808 chr21:46707872 POFUT2;LOC642852 -0.66 -10.2 -0.49 1.89e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9296095 0.747 rs12206050 chr6:33564296 A/T cg14003231 chr6:33640908 ITPR3 0.51 8.04 0.4 1.54e-14 Platelet count; LUSC cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg26384229 chr12:38710491 ALG10B 0.94 17.87 0.7 1.34e-50 Heart rate; LUSC cis rs11971779 0.715 rs7787398 chr7:139061846 A/G cg07862535 chr7:139043722 LUC7L2 0.6 7.47 0.38 6.89e-13 Diisocyanate-induced asthma; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg15112475 chr7:1198522 ZFAND2A -0.38 -8.49 -0.42 6.67e-16 Longevity;Endometriosis; LUSC trans rs11743006 0.626 rs11748042 chr5:136497231 T/A cg07379741 chr17:7311030 NLGN2 0.4 5.97 0.31 6.15e-9 Mathematical ability; LUSC cis rs10992471 0.603 rs10820968 chr9:95106443 A/G cg14631576 chr9:95140430 CENPP -0.38 -6.68 -0.34 1.03e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7223966 1.000 rs9901507 chr17:61765524 G/A cg05941027 chr17:61774174 LIMD2 0.22 5.82 0.3 1.4e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1371867 0.875 rs1788184 chr8:101335106 A/G cg06636551 chr8:101224915 SPAG1 -0.38 -7.13 -0.36 6.31e-12 Atrioventricular conduction; LUSC trans rs62238980 0.614 rs734092 chr22:32462167 C/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -6.06 -0.31 3.6e-9 Childhood ear infection; LUSC cis rs9905704 0.671 rs2068710 chr17:56594535 C/G cg19466818 chr17:56409534 MIR142 0.36 6.82 0.35 4.32e-11 Testicular germ cell tumor; LUSC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.9 -0.35 2.58e-11 Menopause (age at onset); LUSC cis rs6456156 0.586 rs9459862 chr6:167487011 A/G cg07741184 chr6:167504864 NA -0.39 -7.07 -0.36 8.84e-12 Primary biliary cholangitis; LUSC cis rs6598955 0.543 rs3795689 chr1:26560366 C/G cg04990556 chr1:26633338 UBXN11 0.88 11.64 0.54 1.61e-26 Obesity-related traits; LUSC cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg02527881 chr3:46936655 PTH1R -0.4 -7.11 -0.36 7.25e-12 Colorectal cancer; LUSC cis rs8060686 0.516 rs7206792 chr16:68168200 C/G cg09835421 chr16:68378352 PRMT7 -0.47 -5.88 -0.31 9.72e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20185145 chr6:7230113 RREB1 0.48 6.81 0.35 4.57e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.78 0.43 8.85e-17 Prudent dietary pattern; LUSC cis rs765787 0.530 rs4238377 chr15:45541981 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.04e-16 Uric acid levels; LUSC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs10789491 0.767 rs1595898 chr1:47193577 G/A cg15501359 chr1:47185051 KIAA0494 0.78 10.2 0.49 1.91e-21 Response to hepatitis C treatment; LUSC cis rs6582630 0.638 rs10880644 chr12:38554959 G/A cg26384229 chr12:38710491 ALG10B 0.57 8.58 0.42 3.71e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs1865760 0.964 rs6932113 chr6:25913098 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.9 0.35 2.68e-11 Height; LUSC cis rs2730245 1.000 rs2252502 chr7:158738634 G/C cg24397884 chr7:158709396 WDR60 -0.76 -12.13 -0.55 2.63e-28 Height; LUSC trans rs1997103 1.000 rs4628219 chr7:55410449 A/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC trans rs3749237 1.000 rs2291542 chr3:49751585 C/T cg21659725 chr3:3221576 CRBN 0.64 9.29 0.45 2.04e-18 Resting heart rate; LUSC cis rs977987 0.835 rs3863445 chr16:75371744 C/G cg04384234 chr16:75411784 CFDP1 -0.43 -6.89 -0.35 2.74e-11 Dupuytren's disease; LUSC cis rs17407555 0.738 rs56143194 chr4:10067535 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -6.62 -0.34 1.45e-10 Schizophrenia (age at onset); LUSC cis rs11264799 0.765 rs2152710 chr1:157626964 A/G cg18268488 chr1:157545234 FCRL4 0.33 5.8 0.3 1.57e-8 IgA nephropathy; LUSC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.55 0.62 1.76e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg12454169 chr2:30669597 LCLAT1 0.7 9.06 0.44 1.11e-17 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg00316803 chr15:76480434 C15orf27 -0.4 -6.8 -0.35 4.95e-11 Blood metabolite levels; LUSC cis rs240764 0.578 rs9322216 chr6:101251720 A/C cg09795085 chr6:101329169 ASCC3 -0.45 -6.55 -0.34 2.14e-10 Neuroticism; LUSC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg25288140 chr17:41278341 BRCA1;NBR2 0.4 6.06 0.31 3.57e-9 Menopause (age at onset); LUSC cis rs7582720 1.000 rs3845800 chr2:203734365 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.68 -7.76 -0.39 1.05e-13 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1044826 1.000 rs3821544 chr3:139190188 C/T cg00490450 chr3:139108681 COPB2 0.52 6.78 0.35 5.37e-11 Obesity-related traits; LUSC cis rs308403 0.533 rs12644866 chr4:123667604 T/A cg10495464 chr4:123653540 BBS12;LOC729338 0.95 17.16 0.68 9.27e-48 Blood protein levels; LUSC cis rs60154123 0.614 rs12069491 chr1:210460899 A/G cg22029157 chr1:209979665 IRF6 0.51 5.8 0.3 1.56e-8 Coronary artery disease; LUSC cis rs354225 0.626 rs6740893 chr2:54834380 G/A cg26097391 chr2:54893211 SPTBN1 0.39 5.64 0.3 3.54e-8 Schizophrenia; LUSC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -25.14 -0.81 4.96e-79 Height; LUSC trans rs11098499 0.863 rs3775849 chr4:120450908 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg08132940 chr7:1081526 C7orf50 -0.52 -6.07 -0.32 3.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2540226 0.935 rs7591347 chr2:39955465 C/T cg23576258 chr2:39999331 THUMPD2 0.34 5.68 0.3 2.91e-8 Personality dimensions; LUSC cis rs12594515 1.000 rs8029209 chr15:45993489 A/G cg01629716 chr15:45996671 NA 0.38 5.72 0.3 2.31e-8 Waist circumference;Weight; LUSC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg00784671 chr22:46762841 CELSR1 -0.49 -6.06 -0.31 3.75e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.64 -0.39 2.31e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg15445000 chr17:37608096 MED1 0.4 6.74 0.35 6.92e-11 Glomerular filtration rate (creatinine); LUSC cis rs8099014 0.954 rs6566971 chr18:56123702 C/G cg12907477 chr18:56117327 MIR122 0.44 7.04 0.36 1.07e-11 Platelet count; LUSC cis rs559928 0.606 rs11231726 chr11:63987339 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 7.68 0.39 1.78e-13 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.92 -0.31 7.93e-9 Neutrophil percentage of white cells; LUSC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg17330251 chr7:94953956 PON1 -0.39 -6.51 -0.34 2.83e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg06873352 chr17:61820015 STRADA 0.56 8.9 0.44 3.5e-17 Height; LUSC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg23172400 chr8:95962367 TP53INP1 -0.47 -9.59 -0.46 2.13e-19 Type 2 diabetes; LUSC cis rs1448094 0.935 rs11117120 chr12:86336447 G/A cg02569458 chr12:86230093 RASSF9 0.42 6.85 0.35 3.49e-11 Major depressive disorder; LUSC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg03644281 chr6:41068752 NFYA;LOC221442 0.54 7.71 0.39 1.5e-13 Alzheimer's disease (late onset); LUSC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg18876405 chr7:65276391 NA -0.58 -9.31 -0.45 1.8e-18 Aortic root size; LUSC cis rs9788682 0.706 rs2568493 chr15:78740233 G/A cg18825076 chr15:78729989 IREB2 -0.45 -6.1 -0.32 2.87e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg12011299 chr4:100065546 ADH4 -0.72 -11.25 -0.52 4.13e-25 Alcohol dependence; LUSC trans rs28647808 0.748 rs114667516 chr9:136258537 A/G cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg02931644 chr1:25747376 RHCE 0.33 5.94 0.31 7.1e-9 Erythrocyte sedimentation rate; LUSC cis rs7726839 0.794 rs6883536 chr5:599274 G/A cg16447950 chr5:562315 NA -0.47 -6.36 -0.33 6.51e-10 Obesity-related traits; LUSC cis rs4786125 0.581 rs1967404 chr16:6921483 G/A cg03623568 chr16:6915990 A2BP1 -0.46 -7.82 -0.39 6.88e-14 Heart rate variability traits (SDNN); LUSC cis rs3755132 0.633 rs16862856 chr2:15794281 C/G cg12888861 chr2:15731646 DDX1 0.53 7.63 0.39 2.41e-13 Wilms tumor; LUSC cis rs9549260 0.651 rs9549251 chr13:41228650 A/G cg21288729 chr13:41239152 FOXO1 0.64 9.95 0.48 1.38e-20 Red blood cell count; LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg19266014 chr7:2183958 MAD1L1 -0.34 -5.64 -0.3 3.57e-8 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.24 0.52 4.42e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.86 -0.31 1.13e-8 Alzheimer's disease (late onset); LUSC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg02428538 chr16:24856791 SLC5A11 0.51 5.97 0.31 6.03e-9 Intelligence (multi-trait analysis); LUSC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg13628971 chr7:2884303 GNA12 0.47 6.76 0.35 6.34e-11 Height; LUSC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.4 -0.33 5.2e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1451375 0.698 rs11238226 chr7:50645827 A/G cg18232548 chr7:50535776 DDC 0.5 7.58 0.38 3.49e-13 Malaria; LUSC cis rs11209185 0.509 rs1938424 chr1:68431722 A/G cg22082780 chr1:68452167 NA -0.44 -7.16 -0.36 5.29e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs3812762 0.957 rs6484008 chr11:8754148 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.37 6.5 0.34 2.95e-10 Hypospadias; LUSC cis rs4654899 0.680 rs3890762 chr1:21198265 G/A cg01072550 chr1:21505969 NA 0.48 7.39 0.37 1.21e-12 Superior frontal gyrus grey matter volume; LUSC cis rs9395066 0.545 rs10456119 chr6:44889045 C/T cg25276700 chr6:44698697 NA 0.31 6.25 0.32 1.25e-9 Height; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg16145915 chr7:1198662 ZFAND2A -0.71 -14.51 -0.62 2.57e-37 Longevity;Endometriosis; LUSC cis rs2798269 1.000 rs12430739 chr13:22146413 A/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.94 -0.31 7.18e-9 PR segment; LUSC cis rs7216064 0.531 rs6504573 chr17:66015963 C/T cg12091567 chr17:66097778 LOC651250 -0.71 -10.86 -0.51 1.03e-23 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg00409905 chr10:38381863 ZNF37A -0.34 -5.97 -0.31 6.09e-9 Extrinsic epigenetic age acceleration; LUSC cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg06784218 chr1:46089804 CCDC17 -0.55 -11.14 -0.52 1.01e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4073582 0.555 rs521109 chr11:66030948 G/A cg14036092 chr11:66035641 RAB1B 0.45 6.51 0.34 2.75e-10 Gout; LUSC cis rs6906287 0.647 rs7772921 chr6:118964623 C/G cg21191810 chr6:118973309 C6orf204 0.32 5.94 0.31 7.14e-9 Electrocardiographic conduction measures; LUSC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.85 0.35 3.63e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg08677398 chr8:58056175 NA 0.52 6.37 0.33 6.16e-10 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg23711669 chr6:146136114 FBXO30 0.88 16.35 0.67 1.45e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18404041 chr3:52824283 ITIH1 -0.54 -10.44 -0.5 2.98e-22 Electroencephalogram traits; LUSC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg02475777 chr4:1388615 CRIPAK 0.37 5.67 0.3 3.06e-8 Obesity-related traits; LUSC cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg00677455 chr12:58241039 CTDSP2 0.48 6.38 0.33 5.74e-10 Intelligence (multi-trait analysis); LUSC cis rs12824058 0.831 rs7979497 chr12:130804706 C/T cg23887609 chr12:130822674 PIWIL1 0.47 7.1 0.36 7.61e-12 Menopause (age at onset); LUSC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.31 -0.33 8.87e-10 Personality dimensions; LUSC cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.73 0.35 7.22e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs4332037 0.802 rs12113633 chr7:1932936 G/A cg25206134 chr2:45395956 NA 0.57 6.5 0.34 2.92e-10 Bipolar disorder; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg08472276 chr7:1133186 C7orf50;GPER -0.4 -6.63 -0.34 1.38e-10 Longevity;Endometriosis; LUSC cis rs983392 0.679 rs1026252 chr11:60030559 C/T cg20284999 chr11:59952153 MS4A6A 0.37 6.09 0.32 3.02e-9 Alzheimer's disease (late onset); LUSC cis rs2404602 0.647 rs12898416 chr15:77042292 C/G cg23625390 chr15:77176239 SCAPER -0.66 -10.01 -0.48 8.54e-21 Blood metabolite levels; LUSC cis rs3126085 0.935 rs11588174 chr1:152175970 C/T cg26876637 chr1:152193138 HRNR -0.47 -6.6 -0.34 1.65e-10 Atopic dermatitis; LUSC cis rs8078723 0.714 rs9915252 chr17:38145088 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.46 7.52 0.38 5.02e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs79387448 0.745 rs1880000 chr2:103099953 T/C cg09003973 chr2:102972529 NA 0.92 9.12 0.45 7.05e-18 Gut microbiota (bacterial taxa); LUSC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 7.03 0.36 1.18e-11 Multiple sclerosis; LUSC cis rs17125944 0.505 rs74642116 chr14:53213507 A/G cg00686598 chr14:53173677 PSMC6 1.15 10.48 0.5 2.05e-22 Alzheimer's disease (late onset); LUSC cis rs7267979 0.565 rs958075 chr20:25595123 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.69 -12.63 -0.57 3.81e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs701145 0.585 rs1713852 chr3:153795487 C/G cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs17125944 0.505 rs77137752 chr14:53230496 G/T cg00686598 chr14:53173677 PSMC6 1.15 10.47 0.5 2.35e-22 Alzheimer's disease (late onset); LUSC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg02079420 chr8:82753780 SNX16 0.43 7.37 0.37 1.39e-12 Diastolic blood pressure; LUSC cis rs4595586 0.545 rs12812762 chr12:39371141 T/C cg26384229 chr12:38710491 ALG10B 0.49 6.95 0.36 1.93e-11 Morning vs. evening chronotype; LUSC cis rs10197940 0.578 rs1061305 chr2:152346979 T/C cg06191203 chr2:152266755 RIF1 -0.43 -5.92 -0.31 8.12e-9 Lung cancer; LUSC cis rs2637266 0.714 rs1965156 chr10:78450559 G/A cg18941641 chr10:78392320 NA 0.33 5.98 0.31 5.67e-9 Pulmonary function; LUSC cis rs4400599 1.000 rs4845364 chr1:154141908 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.35 -5.73 -0.3 2.29e-8 Platelet distribution width; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19889152 chr6:33588278 ITPR3 0.78 6.25 0.32 1.22e-9 Cognitive performance; LUSC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg11062466 chr8:58055876 NA 0.49 6.45 0.33 3.88e-10 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.641 rs7192187 chr16:68132109 T/C cg05110241 chr16:68378359 PRMT7 -0.51 -6.12 -0.32 2.69e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.57 7.66 0.39 2.07e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg15744005 chr10:104629667 AS3MT -0.29 -6.29 -0.33 9.73e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.7 0.43 1.52e-16 Prudent dietary pattern; LUSC cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg23711669 chr6:146136114 FBXO30 0.87 15.55 0.65 2.07e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg21548813 chr6:291882 DUSP22 -0.52 -7.85 -0.39 5.71e-14 Menopause (age at onset); LUSC cis rs6964587 0.773 rs12740 chr7:92029302 A/G cg17063962 chr7:91808500 NA 0.5 7.39 0.37 1.18e-12 Breast cancer; LUSC cis rs868036 0.718 rs3784710 chr15:68072458 T/C cg24579218 chr15:68104479 NA -0.36 -6.37 -0.33 6.26e-10 Restless legs syndrome; LUSC cis rs12760731 0.641 rs10798605 chr1:178294872 G/A cg00404053 chr1:178313656 RASAL2 0.57 6.56 0.34 2.07e-10 Obesity-related traits; LUSC cis rs2658782 0.547 rs3020054 chr11:93055556 C/T cg15737290 chr11:93063684 CCDC67 0.89 14.31 0.62 1.49e-36 Pulmonary function decline; LUSC cis rs17255340 0.520 rs1170501 chr6:83991861 C/A cg08257003 chr6:84140564 ME1 0.32 7.89 0.4 4.39e-14 Platelet-derived growth factor BB levels; LUSC cis rs3790645 0.958 rs2290589 chr1:26880288 C/T cg17456097 chr1:26900765 RPS6KA1 0.43 6.2 0.32 1.71e-9 Glucose homeostasis traits; LUSC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg03806693 chr22:41940476 POLR3H -1.03 -14.26 -0.62 2.36e-36 Vitiligo; LUSC cis rs782590 0.764 rs2054728 chr2:55818419 C/T cg18811423 chr2:55921094 PNPT1 0.77 12.75 0.57 1.31e-30 Metabolic syndrome; LUSC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -14.08 -0.61 1.14e-35 Extrinsic epigenetic age acceleration; LUSC cis rs4400599 0.618 rs9943097 chr1:154205823 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.9 -0.31 9.07e-9 Platelet distribution width; LUSC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg22823121 chr1:150693482 HORMAD1 0.58 8.9 0.44 3.61e-17 Tonsillectomy; LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.91 14.06 0.61 1.37e-35 Platelet count; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg06873352 chr17:61820015 STRADA 0.72 12.86 0.58 5.23e-31 Prudent dietary pattern; LUSC cis rs17270561 0.608 rs9358875 chr6:25738008 G/A cg16482183 chr6:26056742 HIST1H1C 0.66 9.16 0.45 5.55e-18 Iron status biomarkers; LUSC cis rs10097731 0.908 rs28550260 chr8:82025584 T/C cg25230327 chr8:82042993 NA -0.49 -7.15 -0.36 5.46e-12 Serum total protein level; LUSC cis rs977987 0.835 rs7200616 chr16:75366089 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.1 -0.36 7.41e-12 Dupuytren's disease; LUSC cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg26384229 chr12:38710491 ALG10B 0.88 14.84 0.63 1.28e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs929354 0.553 rs34498858 chr7:156931337 T/C cg17757837 chr7:157058334 UBE3C 0.81 13.02 0.58 1.3e-31 Body mass index; LUSC cis rs7236492 0.532 rs8090536 chr18:77195553 C/T cg15644404 chr18:77186268 NFATC1 -0.51 -7.02 -0.36 1.27e-11 Inflammatory bowel disease;Crohn's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14522847 chr3:15919537 NA -0.77 -6.39 -0.33 5.52e-10 Cognitive performance; LUSC cis rs28647808 0.881 rs4246171 chr9:136264731 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs8017423 1.000 rs4904644 chr14:90665689 A/G cg04374321 chr14:90722782 PSMC1 -0.65 -9.38 -0.46 1.01e-18 Mortality in heart failure; LUSC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg17366294 chr4:99064904 C4orf37 0.6 10.61 0.5 7.4e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg06238570 chr21:40685208 BRWD1 0.47 7.21 0.37 3.81e-12 Cognitive function; LUSC trans rs45509595 0.841 rs200501 chr6:27788942 C/T cg06606381 chr12:133084897 FBRSL1 -0.74 -7.4 -0.38 1.1e-12 Breast cancer; LUSC cis rs300703 0.872 rs7568288 chr2:276908 C/G cg21211680 chr2:198530 NA 0.72 7.52 0.38 4.95e-13 Blood protein levels; LUSC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11890956 chr21:40555474 PSMG1 1.02 20.48 0.75 5.84e-61 Cognitive function; LUSC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg10523679 chr1:76189770 ACADM 0.89 14.2 0.61 4.04e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10489202 0.632 rs12401555 chr1:168069473 G/C cg24449463 chr1:168025552 DCAF6 -0.68 -10.19 -0.49 2.04e-21 Schizophrenia; LUSC cis rs1790761 0.658 rs666328 chr11:67335538 G/A cg08355456 chr11:67383691 NA 0.38 7.01 0.36 1.35e-11 Mean corpuscular volume; LUSC cis rs2742234 0.541 rs871763 chr10:43734188 C/T cg02780029 chr10:43622663 RET 0.34 5.68 0.3 2.97e-8 Hirschsprung disease; LUSC cis rs926938 0.552 rs360613 chr1:115394864 C/G cg01522456 chr1:115632236 TSPAN2 -0.41 -6.53 -0.34 2.47e-10 Autism; LUSC cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.35e-9 Blood metabolite levels; LUSC trans rs6076960 0.684 rs6054058 chr20:6262187 T/C cg17788362 chr6:86352627 SYNCRIP 0.48 7.23 0.37 3.35e-12 Smooth-surface caries; LUSC cis rs7808935 0.914 rs11971132 chr7:27985867 G/C cg22168087 chr7:27702803 HIBADH 0.57 6.77 0.35 5.87e-11 Prostate cancer; LUSC cis rs9921338 0.961 rs9936093 chr16:11437316 C/G cg00044050 chr16:11439710 C16orf75 -0.5 -6.67 -0.34 1.07e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2797160 0.967 rs1777224 chr6:126019527 T/C cg05901451 chr6:126070800 HEY2 0.57 8.71 0.43 1.38e-16 Endometrial cancer; LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg21724239 chr8:58056113 NA 0.79 9.68 0.47 1.07e-19 Developmental language disorder (linguistic errors); LUSC cis rs796364 0.755 rs6739563 chr2:201134216 A/C cg23649088 chr2:200775458 C2orf69 0.53 6.45 0.33 3.97e-10 Schizophrenia; LUSC cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Bone mineral density; LUSC cis rs9914988 0.613 rs1873477 chr17:27311532 A/G cg10538030 chr17:27276405 PHF12 -0.56 -5.66 -0.3 3.28e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7264396 1.000 rs224434 chr20:34153856 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.21 -0.37 3.65e-12 Total cholesterol levels; LUSC trans rs11098499 0.955 rs13113112 chr4:120156040 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.44 6.06 0.31 3.69e-9 Corneal astigmatism; LUSC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg08975724 chr8:8085496 FLJ10661 0.52 8.08 0.4 1.17e-14 Systolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22387939 chr2:71175719 ATP6V1B1 -0.38 -5.97 -0.31 5.97e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9341808 0.622 rs682482 chr6:80961139 A/G cg08355045 chr6:80787529 NA -0.41 -6.87 -0.35 3.2e-11 Sitting height ratio; LUSC trans rs7615952 0.736 rs9862893 chr3:125686974 A/G cg07211511 chr3:129823064 LOC729375 -1.03 -12.92 -0.58 3.13e-31 Blood pressure (smoking interaction); LUSC cis rs9815354 0.812 rs967619 chr3:41876710 C/G cg03022575 chr3:42003672 ULK4 0.84 8.86 0.44 4.79e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg22782873 chr19:19639568 YJEFN3 0.49 6.17 0.32 2e-9 Bipolar disorder; LUSC cis rs4964805 0.710 rs1866296 chr12:104187092 G/A cg02344784 chr12:104178138 NT5DC3 0.46 8.86 0.44 4.96e-17 Attention deficit hyperactivity disorder; LUSC cis rs28830936 0.966 rs1107858 chr15:41968226 G/A cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.23 -0.32 1.43e-9 Diastolic blood pressure; LUSC trans rs35110281 0.720 rs162394 chr21:44943550 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.62 -10.97 -0.51 3.94e-24 Mean corpuscular volume; LUSC trans rs12145833 0.596 rs12043646 chr1:243281992 G/A cg25284624 chr1:224180302 NA 0.65 6.27 0.32 1.11e-9 Obesity (early onset extreme); LUSC cis rs10193935 1.000 rs13421289 chr2:42412808 T/C cg27598129 chr2:42591480 NA -0.61 -8.05 -0.4 1.48e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7246967 0.673 rs8106215 chr19:22879446 G/A cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9341808 0.935 rs942381 chr6:80880150 T/G cg08355045 chr6:80787529 NA 0.52 9.2 0.45 3.94e-18 Sitting height ratio; LUSC cis rs3126085 0.877 rs4845742 chr1:152183949 G/A cg03465714 chr1:152285911 FLG -0.42 -5.88 -0.31 9.75e-9 Atopic dermatitis; LUSC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg24110177 chr3:50126178 RBM5 0.65 11.69 0.54 1.1e-26 Body mass index; LUSC cis rs72781680 0.611 rs74661620 chr2:24365260 C/A cg20701182 chr2:24300061 SF3B14 0.83 10.2 0.49 1.89e-21 Lymphocyte counts; LUSC cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg03146154 chr1:46216737 IPP 0.52 7.83 0.39 6.52e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg13390004 chr1:15929781 NA 0.42 6.95 0.36 1.92e-11 Systolic blood pressure; LUSC cis rs9326248 0.581 rs12225187 chr11:116793231 G/A cg20608306 chr11:116969690 SIK3 0.37 6.95 0.36 1.9e-11 Blood protein levels; LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg21856205 chr7:94953877 PON1 -0.45 -8.57 -0.42 3.94e-16 Paraoxonase activity; LUSC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg06582575 chr6:163149167 PACRG;PARK2 1.1 15.88 0.66 1.04e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.518 rs13133925 chr4:98706398 G/T cg03676636 chr4:99064102 C4orf37 0.29 5.67 0.3 3.13e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9311676 0.632 rs4130877 chr3:58374893 T/C cg26110898 chr3:58419937 PDHB 0.41 6.65 0.34 1.17e-10 Systemic lupus erythematosus; LUSC cis rs1153858 1.000 rs1153858 chr15:45652703 A/G cg14582100 chr15:45693742 SPATA5L1 -0.57 -10.4 -0.49 4.06e-22 Homoarginine levels; LUSC cis rs10876993 0.893 rs4760168 chr12:58087737 T/G cg18357645 chr12:58087776 OS9 0.6 9.0 0.44 1.68e-17 Celiac disease or Rheumatoid arthritis; LUSC cis rs1372520 0.577 rs2737021 chr4:90739992 T/A cg15133208 chr4:90757351 SNCA -0.53 -8.24 -0.41 3.95e-15 Neuroticism; LUSC trans rs3891355 1.000 rs3851637 chr12:106951107 A/C cg18191209 chr2:795478 NA 0.45 6.17 0.32 1.97e-9 Cognitive test performance; LUSC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg02034447 chr16:89574710 SPG7 0.4 5.91 0.31 8.5e-9 Multiple myeloma (IgH translocation); LUSC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg07936489 chr17:37558343 FBXL20 -0.72 -9.87 -0.48 2.59e-20 Glomerular filtration rate (creatinine); LUSC cis rs68170813 0.559 rs78610616 chr7:106951369 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.53 -0.46 3.25e-19 Coronary artery disease; LUSC cis rs35306767 0.714 rs7075188 chr10:1088746 G/T cg20503657 chr10:835505 NA -0.52 -6.96 -0.36 1.86e-11 Eosinophil percentage of granulocytes; LUSC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18404041 chr3:52824283 ITIH1 -0.58 -11.25 -0.52 4.15e-25 Bipolar disorder; LUSC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg16584290 chr5:462447 EXOC3 -0.34 -6.02 -0.31 4.7e-9 Cystic fibrosis severity; LUSC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg17507749 chr15:85114479 UBE2QP1 0.69 9.22 0.45 3.35e-18 Schizophrenia; LUSC cis rs2204008 0.571 rs1117803 chr12:38281007 C/G cg13010199 chr12:38710504 ALG10B -0.47 -7.02 -0.36 1.24e-11 Bladder cancer; LUSC trans rs7824557 0.843 rs2572418 chr8:11113089 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.34 -0.33 7.57e-10 Retinal vascular caliber; LUSC cis rs7149337 0.836 rs12588488 chr14:51660217 C/A cg23942311 chr14:51606299 NA 0.47 10.32 0.49 7.45e-22 Cancer; LUSC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg27432699 chr2:27873401 GPN1 -0.63 -9.7 -0.47 9.31e-20 Total body bone mineral density; LUSC cis rs5769707 0.592 rs6009783 chr22:50011001 C/G cg20744362 chr22:50050164 C22orf34 0.39 7.11 0.36 6.99e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2839186 0.934 rs4819221 chr21:47695417 G/T cg11766577 chr21:47581405 C21orf56 0.42 6.4 0.33 5.22e-10 Testicular germ cell tumor; LUSC trans rs7647973 0.626 rs9824435 chr3:49674343 A/G cg21659725 chr3:3221576 CRBN 0.7 8.6 0.43 3.17e-16 Menarche (age at onset); LUSC cis rs12701220 0.541 rs12535516 chr7:1114440 C/G cg00990874 chr7:1149470 C7orf50 -0.51 -6.09 -0.32 3.17e-9 Bronchopulmonary dysplasia; LUSC cis rs10832963 1.000 rs10832956 chr11:18645668 A/G cg20219074 chr11:18656078 SPTY2D1 0.72 10.68 0.5 4.17e-23 Breast cancer; LUSC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg11645453 chr3:52864694 ITIH4 0.31 7.22 0.37 3.6e-12 Bipolar disorder; LUSC cis rs501916 0.796 rs55961203 chr15:48050518 G/T cg16110827 chr15:48056943 SEMA6D -0.44 -6.84 -0.35 3.83e-11 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7598759 0.617 rs6437017 chr2:232327584 C/A cg19187155 chr2:232395269 NMUR1 0.49 7.16 0.36 5.16e-12 Noise-induced hearing loss; LUSC cis rs727505 0.954 rs1383748 chr7:124638201 A/T cg23710748 chr7:124431027 NA -0.37 -6.46 -0.33 3.71e-10 Lewy body disease; LUSC trans rs9329221 0.725 rs11250001 chr8:10255901 G/A cg15556689 chr8:8085844 FLJ10661 -0.58 -7.99 -0.4 2.18e-14 Neuroticism; LUSC cis rs7223966 1.000 rs8075257 chr17:61728750 G/C cg05941027 chr17:61774174 LIMD2 0.21 5.7 0.3 2.66e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.78 0.43 8.47e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg14004847 chr7:1930337 MAD1L1 -0.59 -9.2 -0.45 3.95e-18 Schizophrenia; LUSC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs2404602 0.647 rs12439141 chr15:77095423 T/C cg23625390 chr15:77176239 SCAPER -0.65 -9.8 -0.47 4.36e-20 Blood metabolite levels; LUSC cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg07606381 chr6:8435919 SLC35B3 0.72 11.9 0.55 1.79e-27 Motion sickness; LUSC cis rs477692 0.673 rs1970197 chr10:131359588 C/T cg05714579 chr10:131428358 MGMT 0.46 6.48 0.33 3.29e-10 Response to temozolomide; LUSC cis rs7089973 0.604 rs7920216 chr10:116611794 G/A cg23260525 chr10:116636907 FAM160B1 0.45 9.6 0.47 1.91e-19 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg19622623 chr12:86230825 RASSF9 -0.46 -6.43 -0.33 4.47e-10 Major depressive disorder; LUSC trans rs7681440 0.845 rs6843084 chr4:90766230 T/C cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.55 0.38 4.11e-13 Motion sickness; LUSC cis rs34779708 0.931 rs13377158 chr10:35370465 A/C cg04310649 chr10:35416472 CREM 0.4 6.23 0.32 1.43e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.49 8.84 0.44 5.63e-17 Total body bone mineral density; LUSC cis rs6683071 0.601 rs3002129 chr1:222855335 C/G cg09820183 chr1:222886073 C1orf58;AIDA 0.5 5.73 0.3 2.3e-8 Cognitive performance; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg02603726 chr16:18812963 ARL6IP1 0.42 5.96 0.31 6.56e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11644478 chr21:40555479 PSMG1 -0.8 -13.18 -0.58 3.28e-32 Cognitive function; LUSC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg18876405 chr7:65276391 NA -0.54 -8.52 -0.42 5.68e-16 Aortic root size; LUSC cis rs13242816 1.000 rs62471189 chr7:116101588 G/A cg16553024 chr7:116138462 CAV2 -0.54 -5.87 -0.31 1.05e-8 P wave duration; LUSC trans rs11696501 0.688 rs6104247 chr20:44244938 C/T cg03272292 chr12:48577362 C12orf68 0.54 6.49 0.33 3.1e-10 Brain structure; LUSC cis rs13108904 0.935 rs922698 chr4:1282722 C/T cg27284194 chr4:1044797 NA -0.36 -5.86 -0.31 1.11e-8 Obesity-related traits; LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg11494091 chr17:61959527 GH2 0.63 13.36 0.59 6.42e-33 Prudent dietary pattern; LUSC cis rs6496667 0.557 rs2526002 chr15:90965655 C/T cg22089800 chr15:90895588 ZNF774 0.53 7.68 0.39 1.82e-13 Rheumatoid arthritis; LUSC cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg10172584 chr19:19639581 YJEFN3 0.47 5.74 0.3 2.1e-8 Bipolar disorder; LUSC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg17279839 chr7:150038598 RARRES2 0.4 6.44 0.33 4.21e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs4909189 1.000 rs62493651 chr7:158135592 T/C cg06219351 chr7:158114137 PTPRN2 -0.53 -8.41 -0.42 1.24e-15 Response to amphetamines; LUSC cis rs9611565 0.592 rs6519270 chr22:42078666 A/G cg17376030 chr22:41985996 PMM1 -0.46 -6.07 -0.32 3.54e-9 Vitiligo; LUSC cis rs4780355 0.918 rs1646019 chr16:11359680 C/T cg00044050 chr16:11439710 C16orf75 0.56 8.39 0.42 1.35e-15 Crohn's disease and psoriasis; LUSC cis rs6665290 0.545 rs6426584 chr1:227374949 A/T cg10327440 chr1:227177885 CDC42BPA -0.99 -17.15 -0.68 1e-47 Myeloid white cell count; LUSC trans rs7567288 0.636 rs13007239 chr2:134461484 A/C cg12381416 chr3:14359266 NA 0.56 6.29 0.33 1.02e-9 Height; LUSC cis rs117352156 0.800 rs2887379 chr10:29214731 T/C cg06394621 chr10:29236369 NA -0.47 -6.34 -0.33 7.38e-10 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs854765 0.583 rs6502622 chr17:17834691 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.74 13.04 0.58 1.07e-31 Total body bone mineral density; LUSC cis rs6733011 0.578 rs4851170 chr2:99504323 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.42 6.13 0.32 2.51e-9 Bipolar disorder; LUSC cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.91 -0.44 3.31e-17 Monocyte percentage of white cells; LUSC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs6494488 0.500 rs113645218 chr15:64843582 C/T cg08069370 chr15:64387884 SNX1 -0.64 -5.65 -0.3 3.48e-8 Coronary artery disease; LUSC cis rs654950 0.901 rs1885654 chr1:42007188 C/A cg06885757 chr1:42089581 HIVEP3 -0.44 -8.56 -0.42 4.05e-16 Airway imaging phenotypes; LUSC cis rs77741769 0.571 rs10849807 chr12:121314056 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.57 0.42 3.84e-16 Mean corpuscular volume; LUSC cis rs11098499 0.865 rs9994730 chr4:120381564 A/C cg09307838 chr4:120376055 NA 0.77 11.2 0.52 6.24e-25 Corneal astigmatism; LUSC cis rs11229555 1.000 rs3168135 chr11:58386177 G/A cg15696309 chr11:58395628 NA -0.69 -9.27 -0.45 2.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs600626 0.636 rs11236515 chr11:75451411 A/G cg24262691 chr11:75473276 NA 0.47 5.89 0.31 9.55e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs3931020 0.688 rs525487 chr1:75217420 A/G cg00121533 chr1:75199117 CRYZ;TYW3 -0.49 -6.17 -0.32 2e-9 Resistin levels; LUSC cis rs3008870 0.755 rs2755254 chr1:67470855 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.33 0.56 5.01e-29 Lymphocyte percentage of white cells; LUSC cis rs4919687 0.550 rs10437480 chr10:104453024 C/G cg05855489 chr10:104503620 C10orf26 0.7 11.37 0.53 1.55e-25 Colorectal cancer; LUSC cis rs1448094 0.872 rs7313373 chr12:86398370 C/G cg00310523 chr12:86230176 RASSF9 0.37 6.83 0.35 4e-11 Major depressive disorder; LUSC cis rs11626933 1.000 rs61989986 chr14:90739180 G/A cg14092571 chr14:90743983 NA -0.9 -18.88 -0.72 1.33e-54 Gut microbiota (bacterial taxa); LUSC trans rs3733585 0.605 rs4697708 chr4:10121189 A/G cg26043149 chr18:55253948 FECH -0.53 -7.87 -0.4 5.02e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.62 0.5 6.57e-23 Bladder cancer; LUSC cis rs7582720 0.667 rs114863726 chr2:204158375 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 7.72 0.39 1.35e-13 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs8078723 0.866 rs3935280 chr17:38189055 A/G cg17467752 chr17:38218738 THRA -0.8 -13.04 -0.58 1.03e-31 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.47 7.34 0.37 1.62e-12 Colorectal cancer; LUSC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg06505273 chr16:24850292 NA 0.4 5.83 0.3 1.33e-8 Intelligence (multi-trait analysis); LUSC cis rs6942756 0.956 rs13235668 chr7:128879710 A/G cg02491457 chr7:128862824 NA -0.53 -7.66 -0.39 2.01e-13 White matter hyperintensity burden; LUSC cis rs13256369 0.802 rs11781257 chr8:8559663 A/T cg17143192 chr8:8559678 CLDN23 0.64 8.85 0.44 5.26e-17 Obesity-related traits; LUSC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg01802117 chr1:53393560 SCP2 -0.37 -6.13 -0.32 2.52e-9 Monocyte count; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg07362569 chr17:61921086 SMARCD2 0.37 7.63 0.39 2.5e-13 Prudent dietary pattern; LUSC cis rs28374715 0.532 rs28477406 chr15:41642036 C/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -22.67 -0.78 1.45e-69 Ulcerative colitis; LUSC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg26513180 chr16:89883248 FANCA -0.52 -7.83 -0.39 6.42e-14 Vitiligo; LUSC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg11764359 chr7:65958608 NA 0.7 11.0 0.52 3.29e-24 Aortic root size; LUSC cis rs5769707 0.681 rs135879 chr22:50018651 C/T cg07959070 chr22:50026188 C22orf34 -0.33 -6.3 -0.33 9.33e-10 Monocyte count;Monocyte percentage of white cells; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg19266034 chr7:108210536 THAP5;DNAJB9 0.38 6.05 0.31 3.92e-9 Mosquito bite size; LUSC cis rs2204008 0.693 rs12372025 chr12:38202028 G/A cg26384229 chr12:38710491 ALG10B 0.94 15.99 0.66 4.04e-43 Bladder cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22975147 chr17:8021903 ALOXE3 0.43 6.14 0.32 2.34e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg22467129 chr15:76604101 ETFA -0.44 -7.1 -0.36 7.7e-12 Blood metabolite levels; LUSC cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC cis rs3772130 0.775 rs6781857 chr3:121560721 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.68 9.91 0.48 1.88e-20 Cognitive performance; LUSC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg26408565 chr15:76604113 ETFA -0.52 -8.32 -0.41 2.23e-15 Blood metabolite levels; LUSC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.11 -0.41 9.78e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg12463550 chr7:65579703 CRCP 0.51 7.52 0.38 5.19e-13 Aortic root size; LUSC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg08048268 chr3:133502702 NA -0.33 -6.27 -0.32 1.09e-9 Iron status biomarkers; LUSC cis rs6669072 0.647 rs814543 chr1:91241709 C/T cg08895590 chr1:91227319 NA 0.38 8.57 0.42 3.86e-16 Cognitive function; LUSC cis rs4343996 1.000 rs6461993 chr7:3356463 G/A cg21248987 chr7:3385318 SDK1 -0.36 -6.16 -0.32 2.04e-9 Motion sickness; LUSC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.8 -0.35 4.73e-11 Lung cancer; LUSC cis rs11690935 0.959 rs2292815 chr2:172586651 C/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.53 -0.62 2.1e-37 Schizophrenia; LUSC cis rs2354432 0.556 rs57388899 chr1:146773422 T/C cg25205988 chr1:146714368 CHD1L -0.99 -10.48 -0.5 2.15e-22 Mitochondrial DNA levels; LUSC cis rs965513 1.000 rs4743131 chr9:100554907 C/G cg13688889 chr9:100608707 NA -0.54 -8.16 -0.41 6.68e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18099408 chr3:52552593 STAB1 -0.41 -7.0 -0.36 1.38e-11 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23791442 chr22:43010704 POLDIP3;RNU12 -0.39 -5.95 -0.31 6.65e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7512552 0.839 rs11577600 chr1:150407443 G/A cg15654264 chr1:150340011 RPRD2 0.63 10.29 0.49 9.21e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13012494 chr21:47604986 C21orf56 0.47 7.15 0.36 5.45e-12 Testicular germ cell tumor; LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg03693601 chr16:46655349 SHCBP1 -0.37 -5.95 -0.31 6.72e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg08330031 chr10:104623503 C10orf32 -0.32 -5.78 -0.3 1.68e-8 Arsenic metabolism; LUSC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg18350739 chr11:68623251 NA -0.38 -6.74 -0.35 7.09e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs17152411 1.000 rs17152433 chr10:126670356 G/A cg07906193 chr10:126599966 NA 0.37 5.69 0.3 2.84e-8 Height; LUSC trans rs11098499 0.562 rs2389879 chr4:120557684 G/A cg25214090 chr10:38739885 LOC399744 -0.4 -6.42 -0.33 4.56e-10 Corneal astigmatism; LUSC cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg00857998 chr1:205179979 DSTYK 0.59 8.8 0.43 7.22e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6740322 0.895 rs10166994 chr2:43557977 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.52 -0.38 5.27e-13 Coronary artery disease; LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg16325326 chr1:53192061 ZYG11B -0.83 -14.41 -0.62 5.88e-37 Monocyte count; LUSC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg17294928 chr15:75287854 SCAMP5 -0.85 -11.07 -0.52 1.83e-24 Blood trace element (Zn levels); LUSC cis rs870825 0.518 rs12512933 chr4:185665055 C/T cg04058563 chr4:185651563 MLF1IP 0.79 10.61 0.5 7.24e-23 Blood protein levels; LUSC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg06951627 chr6:26196580 NA 0.54 5.84 0.3 1.27e-8 Gout;Renal underexcretion gout; LUSC cis rs1448094 0.967 rs10863109 chr12:86328415 A/G cg18827107 chr12:86230957 RASSF9 -0.41 -5.99 -0.31 5.43e-9 Major depressive disorder; LUSC cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg23711669 chr6:146136114 FBXO30 0.89 16.27 0.66 3.05e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs3806843 1.000 rs12717860 chr5:140171442 C/T cg19875535 chr5:140030758 IK 0.49 7.87 0.4 5.04e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.72 -11.06 -0.52 1.95e-24 Lymphocyte counts; LUSC cis rs9584850 0.834 rs7985565 chr13:99113471 C/G cg20487152 chr13:99095054 FARP1 0.4 6.3 0.33 9.31e-10 Neuroticism; LUSC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg09033563 chr22:24373618 LOC391322 0.49 5.91 0.31 8.55e-9 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs4561483 0.583 rs12149833 chr16:12003723 C/T cg08843971 chr16:11963173 GSPT1 0.42 6.32 0.33 8.53e-10 Testicular germ cell tumor; LUSC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs2204008 0.571 rs8175738 chr12:38311234 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 4.77e-15 Bladder cancer; LUSC cis rs9611565 0.879 rs5758307 chr22:41750219 A/G cg03806693 chr22:41940476 POLR3H -0.78 -11.16 -0.52 8.55e-25 Vitiligo; LUSC cis rs1003719 0.715 rs2835658 chr21:38565201 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.7e-21 Eye color traits; LUSC cis rs4888262 0.564 rs6564147 chr16:74622586 G/A cg01733217 chr16:74700730 RFWD3 0.8 13.42 0.59 3.86e-33 Testicular germ cell tumor; LUSC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg27494647 chr7:150038898 RARRES2 0.51 7.86 0.4 5.3e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs1577917 0.771 rs2758844 chr6:86330115 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.1 -0.52 1.36e-24 Response to antipsychotic treatment; LUSC cis rs9467711 0.591 rs67296946 chr6:26048559 T/G cg21479132 chr6:26055353 NA 0.59 5.74 0.3 2.09e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2404618 0.504 rs2906567 chr8:1494118 C/T cg13402656 chr8:1511478 DLGAP2 -0.73 -12.5 -0.56 1.14e-29 Lung cancer; LUSC cis rs1624802 0.966 rs1707933 chr12:130497813 T/G cg15444478 chr12:130494697 NA -0.24 -5.73 -0.3 2.26e-8 Obesity-related traits; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.57 -0.5 1.04e-22 Alzheimer's disease; LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs7584330 0.697 rs9287620 chr2:238368730 C/T cg14458575 chr2:238380390 NA 0.74 13.16 0.58 3.79e-32 Prostate cancer; LUSC trans rs867371 0.717 rs3858954 chr15:82558034 G/C cg18393722 chr15:85113863 UBE2QP1 -0.48 -7.01 -0.36 1.35e-11 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg19717773 chr7:2847554 GNA12 -0.4 -6.21 -0.32 1.58e-9 Height; LUSC cis rs10207060 0.500 rs4380264 chr2:240699378 G/T cg07506560 chr2:240697449 NA 0.46 6.81 0.35 4.45e-11 Obesity-related traits; LUSC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg23277830 chr1:3704460 LRRC47 0.36 6.84 0.35 3.9e-11 Red cell distribution width; LUSC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC trans rs7155454 0.935 rs4466998 chr14:65475540 C/A cg18497238 chr14:75083495 NA -0.25 -6.0 -0.31 5.04e-9 Mean corpuscular volume;Red blood cell traits;Mean corpuscular hemoglobin; LUSC cis rs240768 0.655 rs72939355 chr6:101005363 A/C cg12253828 chr6:101329408 ASCC3 0.84 5.74 0.3 2.11e-8 Economic and political preferences (immigration/crime); LUSC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg04414720 chr1:150670196 GOLPH3L 0.54 8.57 0.42 4.03e-16 Tonsillectomy; LUSC cis rs7707921 0.881 rs2629744 chr5:81381997 A/T cg15871215 chr5:81402204 ATG10 -0.45 -6.6 -0.34 1.64e-10 Breast cancer; LUSC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg21724239 chr8:58056113 NA 0.54 6.64 0.34 1.27e-10 Developmental language disorder (linguistic errors); LUSC cis rs3806843 0.576 rs246029 chr5:140333226 G/A cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg05340658 chr4:99064831 C4orf37 0.63 10.01 0.48 8.32e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs9650657 0.589 rs6985109 chr8:10761585 A/G cg06636001 chr8:8085503 FLJ10661 0.54 7.62 0.38 2.72e-13 Neuroticism; LUSC cis rs4654899 0.897 rs10799668 chr1:21169385 T/C cg01072550 chr1:21505969 NA 0.48 7.28 0.37 2.44e-12 Superior frontal gyrus grey matter volume; LUSC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg22903471 chr2:27725779 GCKR -0.41 -6.95 -0.36 1.98e-11 Menopause (age at onset); LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.47 -7.88 -0.4 4.68e-14 Lymphocyte counts; LUSC cis rs7106204 0.920 rs7946615 chr11:24221036 T/C ch.11.24196551F chr11:24239977 NA 0.99 9.97 0.48 1.12e-20 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg05368731 chr17:41323189 NBR1 0.83 13.45 0.59 2.99e-33 Menopause (age at onset); LUSC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.28 -0.45 2.26e-18 Gut microbiome composition (summer); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg02386183 chr20:13619553 TASP1 -0.33 -5.97 -0.31 6.03e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1018697 1.000 rs1018697 chr10:104549224 C/A cg04362960 chr10:104952993 NT5C2 0.47 6.45 0.33 4.04e-10 Colorectal adenoma (advanced); LUSC cis rs6430585 0.528 rs78274583 chr2:136734569 C/T cg07169764 chr2:136633963 MCM6 1.13 17.53 0.69 2.98e-49 Corneal structure; LUSC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg06808227 chr14:105710500 BRF1 -0.68 -10.69 -0.51 3.77e-23 Mean platelet volume;Platelet distribution width; LUSC cis rs1577917 0.958 rs66807489 chr6:86440702 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.93 -0.35 2.22e-11 Response to antipsychotic treatment; LUSC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg12560992 chr17:57184187 TRIM37 -0.82 -14.77 -0.63 2.33e-38 Intelligence (multi-trait analysis); LUSC cis rs4888378 0.535 rs9319483 chr16:75345791 T/C cg07303275 chr16:75499416 TMEM170A -0.44 -5.67 -0.3 3.04e-8 Coronary artery disease; LUSC cis rs2658782 0.688 rs2658768 chr11:93250827 T/C cg15737290 chr11:93063684 CCDC67 0.6 7.2 0.37 4.06e-12 Pulmonary function decline; LUSC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg26677194 chr12:130822605 PIWIL1 0.6 8.98 0.44 1.97e-17 Menopause (age at onset); LUSC cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 2.92e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10203711 0.966 rs10167210 chr2:239601726 A/C cg14580085 chr2:239553406 NA -0.41 -6.92 -0.35 2.25e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7216064 1.000 rs62084248 chr17:65874541 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7575217 0.767 rs62152486 chr2:101745835 A/C cg23907051 chr2:101730305 TBC1D8 -0.28 -7.39 -0.37 1.17e-12 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg18721089 chr20:30220636 NA -0.35 -6.01 -0.31 4.78e-9 Mean corpuscular hemoglobin; LUSC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.23 -0.37 3.36e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03705284 chr1:1051907 C1orf159 -0.4 -6.07 -0.32 3.44e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2976388 0.692 rs1435453 chr8:143780775 C/T cg17252645 chr8:143867129 LY6D 0.39 6.74 0.35 7.09e-11 Urinary tract infection frequency; LUSC cis rs7100689 0.725 rs2487074 chr10:82064104 A/G cg00277334 chr10:82204260 NA -0.54 -7.38 -0.37 1.3e-12 Post bronchodilator FEV1; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18404041 chr3:52824283 ITIH1 -0.66 -13.18 -0.58 3.28e-32 Bipolar disorder; LUSC cis rs8062405 0.690 rs7187604 chr16:28565953 A/G cg07382826 chr16:28625726 SULT1A1 0.28 5.86 0.31 1.11e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs782590 0.967 rs2627759 chr2:55853341 T/C cg18811423 chr2:55921094 PNPT1 0.84 14.61 0.62 1.02e-37 Metabolic syndrome; LUSC cis rs1577917 1.000 rs12199516 chr6:86726221 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.43 -0.42 1.02e-15 Response to antipsychotic treatment; LUSC cis rs3772130 0.583 rs28497949 chr3:121448675 T/A cg20356878 chr3:121714668 ILDR1 0.51 8.26 0.41 3.43e-15 Cognitive performance; LUSC cis rs11105298 0.838 rs10858862 chr12:89842053 T/C cg00757033 chr12:89920650 WDR51B 0.59 10.15 0.49 2.74e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs3760982 0.585 rs62116964 chr19:44291986 T/C cg11993925 chr19:44307056 LYPD5 0.35 7.63 0.39 2.55e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs6121246 0.567 rs6087700 chr20:30217560 A/G cg18721089 chr20:30220636 NA -0.39 -6.12 -0.32 2.66e-9 Mean corpuscular hemoglobin; LUSC cis rs7617480 0.648 rs14018 chr3:48784270 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.65 9.15 0.45 5.79e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.31 -0.37 2e-12 Colorectal cancer; LUSC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg18876405 chr7:65276391 NA -0.55 -8.65 -0.43 2.15e-16 Aortic root size; LUSC cis rs1267303 0.675 rs1267313 chr1:46986322 G/T cg25110126 chr1:46999211 NA -0.56 -7.51 -0.38 5.48e-13 Monobrow; LUSC cis rs71403859 0.730 rs12923781 chr16:71653464 G/A cg08717414 chr16:71523259 ZNF19 -0.71 -7.7 -0.39 1.54e-13 Post bronchodilator FEV1; LUSC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg07936489 chr17:37558343 FBXL20 0.72 10.05 0.48 5.95e-21 Glomerular filtration rate (creatinine); LUSC cis rs2688608 0.933 rs2633307 chr10:75653881 G/A cg23231163 chr10:75533350 FUT11 -0.39 -6.26 -0.32 1.19e-9 Inflammatory bowel disease; LUSC cis rs738322 0.600 rs6001030 chr22:38555904 T/G cg25457927 chr22:38595422 NA -0.33 -6.37 -0.33 6.36e-10 Cutaneous nevi; LUSC trans rs9329221 0.905 rs13254263 chr8:10255181 A/G cg15556689 chr8:8085844 FLJ10661 -0.6 -9.05 -0.44 1.24e-17 Neuroticism; LUSC cis rs7786808 0.649 rs6459879 chr7:158211792 C/G cg01191920 chr7:158217561 PTPRN2 -0.42 -8.44 -0.42 9.69e-16 Obesity-related traits; LUSC cis rs8067287 0.762 rs11651352 chr17:16824909 A/G cg26910001 chr17:16838321 NA 0.43 5.68 0.3 2.97e-8 Diabetic kidney disease; LUSC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg26441486 chr22:50317300 CRELD2 0.48 7.21 0.37 3.88e-12 Schizophrenia; LUSC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11293355 chr13:103249041 TPP2 -0.48 -6.29 -0.33 9.85e-10 Hepatitis; LUSC cis rs7681440 0.904 rs3806789 chr4:90759556 C/T cg01966878 chr4:90757139 SNCA -0.36 -6.11 -0.32 2.82e-9 Dementia with Lewy bodies; LUSC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg00522288 chr12:125625016 AACS -0.32 -5.85 -0.3 1.16e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs798554 0.600 rs2679259 chr7:2885322 C/G cg02423579 chr7:2872169 GNA12 -0.37 -5.87 -0.31 1.07e-8 Height; LUSC cis rs2692947 0.795 rs2252697 chr2:96778190 G/C cg23100626 chr2:96804247 ASTL -0.26 -6.49 -0.33 3.1e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg13256891 chr4:100009986 ADH5 0.51 6.95 0.36 1.91e-11 Smoking initiation; LUSC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg11752832 chr7:134001865 SLC35B4 0.56 8.5 0.42 6.34e-16 Mean platelet volume; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg03354898 chr7:1950403 MAD1L1 0.42 8.42 0.42 1.12e-15 Bipolar disorder and schizophrenia; LUSC cis rs2486288 0.656 rs9921025 chr15:45546602 G/A cg09092052 chr15:45571596 NA 0.45 6.31 0.33 9.03e-10 Glomerular filtration rate; LUSC cis rs9400467 0.508 rs1676863 chr6:111641590 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.33 -0.33 7.87e-10 Blood metabolite levels;Amino acid levels; LUSC trans rs1325195 0.920 rs2816198 chr1:179158736 A/G cg11624085 chr17:8464688 MYH10 0.4 6.53 0.34 2.44e-10 IgE grass sensitization; LUSC trans rs35110281 0.744 rs8131027 chr21:45104908 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.17 0.45 5.01e-18 Mean corpuscular volume; LUSC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg00431813 chr7:1051703 C7orf50 -0.41 -6.9 -0.35 2.68e-11 Longevity;Endometriosis; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg07677032 chr17:61819896 STRADA 0.52 8.7 0.43 1.55e-16 Prudent dietary pattern; LUSC cis rs10751667 1.000 rs11246359 chr11:967943 T/C ch.11.42038R chr11:967971 AP2A2 0.55 8.37 0.42 1.65e-15 Alzheimer's disease (late onset); LUSC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg03676636 chr4:99064102 C4orf37 0.38 8.06 0.4 1.4e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs8114671 0.935 rs6058198 chr20:33748253 T/A cg24642439 chr20:33292090 TP53INP2 0.39 5.65 0.3 3.46e-8 Height; LUSC cis rs2797160 0.935 rs926855 chr6:126021782 A/G cg05901451 chr6:126070800 HEY2 0.57 8.79 0.43 8.03e-17 Endometrial cancer; LUSC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg08677398 chr8:58056175 NA 0.52 6.28 0.32 1.08e-9 Developmental language disorder (linguistic errors); LUSC cis rs11155671 0.530 rs9969044 chr6:150209204 A/G cg07701084 chr6:150067640 NUP43 0.47 6.92 0.35 2.31e-11 Testicular germ cell tumor; LUSC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.23 0.45 3.2e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.66 8.54 0.42 4.72e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs62103177 0.564 rs1715230 chr18:77848002 C/T cg20368463 chr18:77673604 PQLC1 0.63 6.75 0.35 6.53e-11 Opioid sensitivity; LUSC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg00990874 chr7:1149470 C7orf50 -0.6 -7.86 -0.4 5.2e-14 Bronchopulmonary dysplasia; LUSC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.05 -0.31 3.92e-9 Huntington's disease progression; LUSC cis rs2425143 1.000 rs2295356 chr20:34252856 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -6.56 -0.34 2.09e-10 Blood protein levels; LUSC cis rs10165862 0.572 rs11674212 chr2:73911180 C/T cg20560298 chr2:73613845 ALMS1 -0.55 -6.94 -0.35 2.08e-11 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg05340658 chr4:99064831 C4orf37 0.63 10.01 0.48 8.32e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs7584330 0.737 rs6431540 chr2:238360966 T/C cg14458575 chr2:238380390 NA 0.68 12.04 0.55 5.7e-28 Prostate cancer; LUSC cis rs12421382 0.511 rs2212430 chr11:109289538 C/T cg27471124 chr11:109292789 C11orf87 0.54 9.45 0.46 6.12e-19 Schizophrenia; LUSC cis rs644799 0.710 rs56384142 chr11:95502075 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.05 0.61 1.44e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs80282103 0.618 rs2387299 chr10:1163427 A/G cg18964960 chr10:1102726 WDR37 0.71 5.86 0.31 1.11e-8 Glomerular filtration rate (creatinine); LUSC cis rs911555 0.755 rs12435516 chr14:103954404 T/C cg24130564 chr14:104152367 KLC1 0.46 6.55 0.34 2.17e-10 Intelligence (multi-trait analysis); LUSC cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.3 0.37 2.13e-12 Cognitive ability; LUSC cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg06484146 chr7:12443880 VWDE -0.57 -6.07 -0.31 3.57e-9 Coronary artery disease; LUSC cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg15423357 chr2:25149977 NA 0.4 7.83 0.39 6.73e-14 Body mass index; LUSC cis rs4363385 0.720 rs1970328 chr1:152975829 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC cis rs2282300 0.739 rs1616223 chr11:30338783 A/C cg25418670 chr11:30344373 C11orf46 -0.64 -9.23 -0.45 3.29e-18 Morning vs. evening chronotype; LUSC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.71 -0.3 2.45e-8 Depression; LUSC cis rs7707921 0.914 rs4081859 chr5:81466669 G/A cg15871215 chr5:81402204 ATG10 0.45 6.59 0.34 1.69e-10 Breast cancer; LUSC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.56 0.38 3.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10186029 0.582 rs1992395 chr2:214003871 G/T cg08319019 chr2:214017104 IKZF2 -0.47 -7.16 -0.36 5.24e-12 Systemic sclerosis; LUSC cis rs5769707 0.935 rs9616332 chr22:50047678 C/G cg07959070 chr22:50026188 C22orf34 -0.36 -7.34 -0.37 1.69e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg23283495 chr1:209979779 IRF6 0.73 9.53 0.46 3.3e-19 Cleft lip with or without cleft palate; LUSC cis rs394563 0.601 rs391875 chr6:149795136 G/A cg11245181 chr6:149772854 ZC3H12D -0.34 -6.97 -0.36 1.7e-11 Dupuytren's disease; LUSC cis rs62400317 0.859 rs56283067 chr6:45100330 T/C cg18551225 chr6:44695536 NA -0.42 -6.87 -0.35 3.15e-11 Total body bone mineral density; LUSC cis rs308403 0.568 rs13101575 chr4:123617561 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.73 9.46 0.46 5.87e-19 Blood protein levels; LUSC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg18876405 chr7:65276391 NA 0.73 12.88 0.58 4.42e-31 Aortic root size; LUSC cis rs7582180 0.700 rs11685293 chr2:100976502 A/C cg12002119 chr2:101014098 CHST10 0.35 5.99 0.31 5.42e-9 Intelligence (multi-trait analysis); LUSC cis rs7843479 0.930 rs2054713 chr8:21840534 A/G cg17168535 chr8:21777572 XPO7 0.64 9.88 0.48 2.37e-20 Mean corpuscular volume; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg04518342 chr5:131593106 PDLIM4 0.4 7.56 0.38 3.91e-13 Blood metabolite levels; LUSC cis rs941898 0.957 rs941900 chr14:100603399 C/A cg26002632 chr14:100625216 DEGS2 -0.31 -5.71 -0.3 2.46e-8 White matter hyperintensity burden; LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.83 -11.19 -0.52 6.49e-25 Alzheimer's disease; LUSC cis rs9287719 0.967 rs6759714 chr2:10747207 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg20891283 chr12:69753455 YEATS4 0.56 7.73 0.39 1.3e-13 Response to diuretic therapy; LUSC cis rs17253792 0.822 rs77315200 chr14:56072643 C/A cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.86e-12 Putamen volume; LUSC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.59 0.34 1.74e-10 Lung cancer; LUSC cis rs17253792 0.822 rs112739186 chr14:56065167 A/T cg01858014 chr14:56050164 KTN1 -0.86 -6.83 -0.35 4.12e-11 Putamen volume; LUSC cis rs9457247 0.765 rs6900701 chr6:167434112 A/G cg25258033 chr6:167368657 RNASET2 0.43 7.03 0.36 1.15e-11 Crohn's disease; LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg08219700 chr8:58056026 NA 0.66 7.82 0.39 7.08e-14 Developmental language disorder (linguistic errors); LUSC cis rs694739 0.796 rs479777 chr11:64107477 A/G cg26898376 chr11:64110657 CCDC88B 0.31 5.71 0.3 2.54e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs12579753 0.917 rs7132465 chr12:82205840 C/T cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs7208859 0.623 rs11657662 chr17:29076347 A/G cg13385521 chr17:29058706 SUZ12P -0.67 -6.48 -0.33 3.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01045612 chr14:100438192 NA -0.49 -6.11 -0.32 2.7e-9 Bipolar disorder and schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21057228 chr5:122372722 PPIC -0.37 -6.35 -0.33 6.91e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7215564 0.908 rs55886624 chr17:78658657 G/A cg23238734 chr17:78661607 RPTOR 0.48 6.16 0.32 2.07e-9 Myopia (pathological); LUSC cis rs72781680 0.706 rs72796108 chr2:23904990 C/A cg08917208 chr2:24149416 ATAD2B 0.95 9.48 0.46 5.05e-19 Lymphocyte counts; LUSC cis rs1008375 0.900 rs4698625 chr4:17599500 G/T cg16339924 chr4:17578868 LAP3 0.65 9.84 0.47 3.21e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC trans rs7613875 0.620 rs7430334 chr3:50078221 T/C cg21659725 chr3:3221576 CRBN -0.52 -8.37 -0.42 1.61e-15 Body mass index; LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg04414720 chr1:150670196 GOLPH3L -0.48 -7.66 -0.39 2.06e-13 Tonsillectomy; LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg07092213 chr7:1199455 ZFAND2A -0.67 -11.22 -0.52 5.24e-25 Longevity;Endometriosis; LUSC trans rs11989744 0.500 rs1438456 chr8:23566909 T/C cg03492747 chr16:86543808 FOXF1 -0.67 -11.58 -0.54 2.76e-26 Waist-hip ratio; LUSC cis rs9325144 0.647 rs61937754 chr12:39060543 T/C cg13010199 chr12:38710504 ALG10B -0.5 -7.72 -0.39 1.36e-13 Morning vs. evening chronotype; LUSC cis rs1843834 0.823 rs2129610 chr2:225505345 G/A cg22455342 chr2:225449267 CUL3 0.48 6.38 0.33 6.02e-10 IgE levels in asthmatics (D.p. specific); LUSC cis rs9796 0.804 rs28688742 chr15:41403638 G/A cg18705301 chr15:41695430 NDUFAF1 -0.43 -7.45 -0.38 7.97e-13 Menopause (age at onset); LUSC trans rs61931739 0.534 rs10844840 chr12:34364517 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.27 0.49 1.14e-21 Morning vs. evening chronotype; LUSC cis rs3845702 0.736 rs16867131 chr2:180848651 A/G cg01881094 chr2:180872142 CWC22 -1.02 -12.31 -0.56 5.68e-29 Schizophrenia; LUSC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg03690763 chr11:133734501 NA -0.32 -5.64 -0.3 3.57e-8 Childhood ear infection; LUSC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg01475377 chr6:109611718 NA -0.37 -6.55 -0.34 2.18e-10 Reticulocyte fraction of red cells; LUSC trans rs11098499 0.866 rs3756156 chr4:120524841 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.74 0.35 6.9e-11 Corneal astigmatism; LUSC cis rs3540 0.557 rs11634314 chr15:91042066 A/C cg22089800 chr15:90895588 ZNF774 -0.64 -9.49 -0.46 4.41e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs977987 0.806 rs1895490 chr16:75392806 G/A cg03315344 chr16:75512273 CHST6 0.5 9.52 0.46 3.51e-19 Dupuytren's disease; LUSC cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg23262073 chr20:60523788 NA -0.41 -5.89 -0.31 9.62e-9 Body mass index; LUSC cis rs9916302 0.706 rs4794808 chr17:37531916 C/T cg07936489 chr17:37558343 FBXL20 0.8 9.85 0.47 2.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2635047 1.000 rs2635045 chr18:44668417 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 7.22 0.37 3.57e-12 Educational attainment; LUSC cis rs61931739 0.853 rs7133716 chr12:34041847 G/C cg06521331 chr12:34319734 NA 0.4 6.61 0.34 1.48e-10 Morning vs. evening chronotype; LUSC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08704250 chr15:31115839 NA 0.39 5.95 0.31 6.69e-9 Huntington's disease progression; LUSC cis rs1507153 0.523 rs236886 chr6:79321534 A/C cg05283184 chr6:79620031 NA 0.38 6.95 0.36 1.94e-11 Sjögren's syndrome; LUSC cis rs9902453 0.726 rs3115088 chr17:28031275 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.31 0.53 2.56e-25 Coffee consumption (cups per day); LUSC cis rs2078087 0.831 rs12024028 chr1:183232982 T/C cg13843938 chr1:183241246 NMNAT2 0.44 5.89 0.31 9.45e-9 Obesity-related traits; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.4 -6.56 -0.34 2.03e-10 Longevity;Endometriosis; LUSC cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs1153858 1.000 rs7169818 chr15:45640191 G/A cg14582100 chr15:45693742 SPATA5L1 0.56 10.16 0.49 2.69e-21 Homoarginine levels; LUSC cis rs79387448 0.701 rs11465596 chr2:102987093 C/A cg09003973 chr2:102972529 NA 1.2 12.53 0.57 8.64e-30 Gut microbiota (bacterial taxa); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17791867 chr7:112579927 C7orf60 0.42 6.26 0.32 1.15e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9952991 0.882 rs2847274 chr18:12777603 T/C cg23544223 chr18:12777786 NA 0.59 6.27 0.32 1.15e-9 Inflammatory skin disease; LUSC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11890956 chr21:40555474 PSMG1 -0.73 -11.2 -0.52 6.06e-25 Menarche (age at onset); LUSC cis rs9549367 0.789 rs3850451 chr13:113905812 C/G cg18105134 chr13:113819100 PROZ -0.69 -9.82 -0.47 3.79e-20 Platelet distribution width; LUSC cis rs6977660 0.714 rs10244210 chr7:19823972 T/C cg07541023 chr7:19748670 TWISTNB 0.6 6.3 0.33 9.45e-10 Thyroid stimulating hormone; LUSC cis rs11971779 0.680 rs2355785 chr7:139070983 C/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg08645402 chr16:4508243 NA 0.48 7.4 0.38 1.09e-12 Schizophrenia; LUSC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg06363034 chr20:62225388 GMEB2 -0.46 -7.72 -0.39 1.4e-13 Glioblastoma; LUSC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg11764359 chr7:65958608 NA 0.54 7.11 0.36 7.23e-12 Aortic root size; LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg16357287 chr18:12947517 SEH1L -0.39 -6.15 -0.32 2.25e-9 QT interval (ambient particulate matter interaction); LUSC cis rs868036 0.718 rs28463100 chr15:68078769 T/C cg08079166 chr15:68083412 MAP2K5 0.41 7.5 0.38 5.85e-13 Restless legs syndrome; LUSC cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg11189052 chr15:85197271 WDR73 -0.49 -5.75 -0.3 2e-8 Schizophrenia; LUSC cis rs13072153 0.793 rs9841477 chr3:123157477 A/C cg13384396 chr3:123167677 ADCY5 0.26 5.82 0.3 1.4e-8 Chronic kidney disease; LUSC cis rs9811920 0.965 rs6767441 chr3:99863183 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.38 5.7 0.3 2.71e-8 Axial length; LUSC cis rs9329221 0.905 rs13252982 chr8:10255105 C/G cg21775007 chr8:11205619 TDH -0.57 -8.39 -0.42 1.36e-15 Neuroticism; LUSC cis rs9463078 0.683 rs227848 chr6:44698499 G/A cg25276700 chr6:44698697 NA 0.3 5.93 0.31 7.5e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2762353 0.904 rs13197514 chr6:25785991 C/T cg12310025 chr6:25882481 NA 0.43 7.36 0.37 1.49e-12 Blood metabolite levels; LUSC cis rs533581 0.866 rs562812 chr16:88970944 G/A cg08484992 chr16:88977278 CBFA2T3 0.32 5.84 0.3 1.26e-8 Social autistic-like traits; LUSC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg13628971 chr7:2884303 GNA12 -0.49 -7.02 -0.36 1.28e-11 Height; LUSC cis rs9527 0.590 rs11191578 chr10:104902337 A/T cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs17539620 0.624 rs62432737 chr6:154834772 G/A cg20019720 chr6:154832845 CNKSR3 0.62 8.65 0.43 2.17e-16 Lipoprotein (a) levels; LUSC cis rs10489202 1.000 rs12727036 chr1:167972147 A/G cg24449463 chr1:168025552 DCAF6 -0.58 -7.27 -0.37 2.56e-12 Schizophrenia; LUSC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg02269571 chr22:50332266 NA -0.58 -8.83 -0.43 6.13e-17 Schizophrenia; LUSC cis rs9815354 0.680 rs79239400 chr3:42030249 C/A cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs2072499 0.898 rs2736609 chr1:156202640 C/T cg24450063 chr1:156163899 SLC25A44 1.06 20.26 0.74 4.47e-60 Testicular germ cell tumor; LUSC cis rs1018836 0.663 rs2205152 chr8:91483618 C/T cg16814680 chr8:91681699 NA 0.63 9.51 0.46 3.77e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14165241 chr9:131315156 SPTAN1 -0.47 -5.96 -0.31 6.53e-9 Bipolar disorder and schizophrenia; LUSC cis rs981844 1.000 rs10517579 chr4:154666321 T/C cg14289246 chr4:154710475 SFRP2 0.46 5.72 0.3 2.36e-8 Response to statins (LDL cholesterol change); LUSC cis rs3101457 0.530 rs10754827 chr1:244528390 A/G cg09033006 chr1:244517177 C1orf100 -0.4 -5.81 -0.3 1.46e-8 Smoking behavior; LUSC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg27432699 chr2:27873401 GPN1 -0.48 -7.09 -0.36 7.82e-12 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs4478858 0.698 rs4949204 chr1:31800415 A/G cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs7829975 0.582 rs11783950 chr8:8597831 A/C cg15556689 chr8:8085844 FLJ10661 -0.55 -7.84 -0.39 6.03e-14 Mood instability; LUSC cis rs2486288 0.656 rs7165039 chr15:45570413 C/G cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.84 -0.51 1.2e-23 Glomerular filtration rate; LUSC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -7.96 -0.4 2.65e-14 Schizophrenia; LUSC cis rs62432291 0.681 rs429339 chr6:159660148 C/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.96 0.44 2.3e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs7123876 0.587 rs55765314 chr11:72360935 C/A cg04827223 chr11:72435913 ARAP1 -0.59 -6.65 -0.34 1.22e-10 Body mass index; LUSC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg17554472 chr22:41940697 POLR3H 0.47 5.84 0.3 1.27e-8 Vitiligo; LUSC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg25072359 chr17:41440525 NA 0.65 9.33 0.45 1.48e-18 Menopause (age at onset); LUSC cis rs11018904 0.861 rs12786959 chr11:89943676 A/T cg26138821 chr11:89956704 CHORDC1 -0.58 -6.64 -0.34 1.3100000000000001e-10 Intelligence (multi-trait analysis); LUSC cis rs7589342 0.862 rs6745887 chr2:106468039 G/A cg16077055 chr2:106428750 NCK2 0.35 6.32 0.33 8.18e-10 Addiction; LUSC cis rs10207060 1.000 rs10207060 chr2:240687289 A/C cg07506560 chr2:240697449 NA 0.47 7.71 0.39 1.45e-13 Obesity-related traits; LUSC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.59 -7.42 -0.38 1e-12 Body mass index (adult); LUSC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg12463550 chr7:65579703 CRCP -0.56 -8.3 -0.41 2.67e-15 Aortic root size; LUSC trans rs796395 0.650 rs675763 chr1:218682119 A/G cg05473648 chr11:79113178 MIR708;ODZ4 -0.35 -5.95 -0.31 6.86e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg19678392 chr7:94953810 PON1 0.49 9.29 0.45 2.1e-18 Paraoxonase activity; LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg22868518 chr11:507468 RNH1 -0.65 -6.07 -0.32 3.46e-9 Body mass index; LUSC cis rs722599 0.748 rs929579 chr14:75330697 C/T cg08847533 chr14:75593920 NEK9 -0.45 -6.48 -0.33 3.25e-10 IgG glycosylation; LUSC cis rs5753618 0.504 rs5749295 chr22:31932895 A/T cg02404636 chr22:31891804 SFI1 0.43 6.25 0.32 1.25e-9 Colorectal cancer; LUSC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg07395648 chr5:131743802 NA 0.42 5.76 0.3 1.94e-8 Breast cancer; LUSC cis rs41271473 0.500 rs4606285 chr1:228887544 G/T cg10167378 chr1:228756711 NA 0.49 7.06 0.36 9.53e-12 Chronic lymphocytic leukemia; LUSC cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.79 0.43 8.04e-17 Menopause (age at onset); LUSC cis rs561341 0.739 rs6505267 chr17:30225950 A/C cg00745463 chr17:30367425 LRRC37B -0.54 -6.96 -0.36 1.84e-11 Hip circumference adjusted for BMI; LUSC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg21918786 chr6:109611834 NA -0.37 -6.25 -0.32 1.22e-9 Reticulocyte fraction of red cells; LUSC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg21724239 chr8:58056113 NA 0.58 6.67 0.34 1.08e-10 Developmental language disorder (linguistic errors); LUSC cis rs3733631 1.000 rs17034046 chr4:104659604 C/T cg24090629 chr4:104641072 TACR3 -0.47 -5.8 -0.3 1.51e-8 Menarche (age at onset); LUSC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg08677398 chr8:58056175 NA 0.41 5.65 0.3 3.37e-8 Developmental language disorder (linguistic errors); LUSC cis rs9325144 0.560 rs7304568 chr12:38632408 G/A cg26384229 chr12:38710491 ALG10B -0.67 -10.4 -0.49 4.08e-22 Morning vs. evening chronotype; LUSC trans rs3857536 0.706 rs7749120 chr6:66889832 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.26 -0.32 1.19e-9 Blood trace element (Cu levels); LUSC cis rs9527 0.590 rs7894959 chr10:104756182 C/T cg05855489 chr10:104503620 C10orf26 0.48 7.03 0.36 1.17e-11 Arsenic metabolism; LUSC cis rs78545713 0.649 rs113407109 chr6:26224403 T/G cg23601095 chr6:26197514 HIST1H3D 0.67 5.68 0.3 2.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg12667521 chr19:29218732 NA 0.56 7.28 0.37 2.48e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2677744 0.626 rs867468 chr15:91498127 G/A cg20750528 chr15:91474456 HDDC3;UNC45A -0.32 -5.64 -0.3 3.58e-8 Attention deficit hyperactivity disorder; LUSC cis rs12493885 0.818 rs61791543 chr3:153766797 C/G cg17054900 chr3:154042577 DHX36 -0.75 -7.66 -0.39 2.06e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs548181 0.536 rs503287 chr11:125461788 C/T cg03464685 chr11:125439445 EI24 1.16 14.13 0.61 7.04e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9467773 0.549 rs9467805 chr6:26583366 C/T cg09904177 chr6:26538194 HMGN4 0.7 12.48 0.56 1.34e-29 Intelligence (multi-trait analysis); LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg08888203 chr3:10149979 C3orf24 0.63 8.88 0.44 4.16e-17 Alzheimer's disease; LUSC trans rs7937682 0.632 rs3944619 chr11:111774743 A/G cg18187862 chr3:45730750 SACM1L -0.55 -6.65 -0.34 1.16e-10 Primary sclerosing cholangitis; LUSC cis rs9649213 0.511 rs6950994 chr7:97887872 G/A cg21770322 chr7:97807741 LMTK2 0.46 7.74 0.39 1.19e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs7583236 0.500 rs7565597 chr2:70336070 T/G cg19638749 chr2:70312615 NA 0.54 6.01 0.31 4.83e-9 Obesity-related traits; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04977109 chr17:46125622 NFE2L1 0.42 6.05 0.31 3.87e-9 Triglycerides; LUSC cis rs2180341 0.538 rs4577822 chr6:127712911 T/G cg27446573 chr6:127587934 RNF146 0.46 7.02 0.36 1.24e-11 Breast cancer; LUSC trans rs2243480 1.000 rs1392104 chr7:65759107 G/A cg10756647 chr7:56101905 PSPH -0.87 -8.66 -0.43 2.02e-16 Diabetic kidney disease; LUSC cis rs11971779 0.616 rs1862878 chr7:139019914 C/G cg23387468 chr7:139079360 LUC7L2 0.42 6.25 0.32 1.26e-9 Diisocyanate-induced asthma; LUSC cis rs6500395 1.000 rs12597569 chr16:48693342 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg01879757 chr17:41196368 BRCA1 -0.46 -7.09 -0.36 8.16e-12 Menopause (age at onset); LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg26354017 chr1:205819088 PM20D1 0.81 14.59 0.62 1.19e-37 Menarche (age at onset); LUSC cis rs6969780 0.778 rs2428434 chr7:27145735 T/A cg26364809 chr7:27145159 NA -0.59 -5.98 -0.31 5.69e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs394563 0.663 rs415434 chr6:149772645 A/G cg07828024 chr6:149772892 ZC3H12D -0.35 -7.73 -0.39 1.25e-13 Dupuytren's disease; LUSC cis rs2204008 0.540 rs1672425 chr12:38122842 G/A cg26384229 chr12:38710491 ALG10B -0.68 -10.58 -0.5 9.56e-23 Bladder cancer; LUSC cis rs2274273 0.686 rs66782529 chr14:55587867 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.58 0.46 2.26e-19 Protein biomarker; LUSC cis rs9300255 0.782 rs12809602 chr12:123768916 T/G cg00376283 chr12:123451042 ABCB9 -0.68 -7.57 -0.38 3.68e-13 Neutrophil percentage of white cells; LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.06 -0.52 1.96e-24 Alzheimer's disease; LUSC cis rs7929679 0.521 rs1509667 chr11:34791303 G/A cg06937548 chr11:34938143 PDHX;APIP 0.4 5.91 0.31 8.29e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs7267979 0.966 rs6083817 chr20:25343998 G/C cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12620999 0.555 rs4078064 chr2:238110296 C/T cg23555395 chr2:238036564 NA -0.33 -6.12 -0.32 2.6e-9 Systemic lupus erythematosus; LUSC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg20203395 chr5:56204925 C5orf35 -0.44 -6.39 -0.33 5.45e-10 Coronary artery disease; LUSC cis rs3096299 0.746 rs9931120 chr16:89501357 A/G cg02187348 chr16:89574699 SPG7 0.54 8.56 0.42 4.1e-16 Multiple myeloma (IgH translocation); LUSC cis rs7824557 0.527 rs2572449 chr8:11239137 A/G cg21775007 chr8:11205619 TDH 0.65 10.85 0.51 1.1e-23 Retinal vascular caliber; LUSC cis rs2276314 1.000 rs2298716 chr18:33552598 C/T cg19628046 chr18:33552617 C18orf21 0.5 6.15 0.32 2.16e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7267979 1.000 rs7020 chr20:25278600 G/A cg08601574 chr20:25228251 PYGB 0.44 6.67 0.34 1.04e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7089973 0.604 rs58587374 chr10:116597572 A/G cg23260525 chr10:116636907 FAM160B1 0.43 9.23 0.45 3.24e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg23992470 chr4:843637 GAK -0.54 -5.91 -0.31 8.42e-9 Intelligence (multi-trait analysis); LUSC cis rs4809219 1 rs4809219 chr20:62303115 C/A cg09650180 chr20:62225654 GMEB2 0.45 5.9 0.31 8.83e-9 Atopic dermatitis; LUSC cis rs6867032 0.958 rs9312970 chr5:2002415 C/A cg26168224 chr5:2018326 NA -0.74 -13.08 -0.58 7.31e-32 Gut microbiome composition (winter); LUSC cis rs2204008 0.570 rs12318341 chr12:38251087 T/C cg13010199 chr12:38710504 ALG10B -0.47 -7.02 -0.36 1.24e-11 Bladder cancer; LUSC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg03929089 chr4:120376271 NA -0.96 -15.51 -0.65 3.14e-41 Coronary artery disease; LUSC cis rs9920506 0.536 rs11636605 chr15:78928878 A/G cg05914723 chr15:78953907 NA -0.35 -5.69 -0.3 2.79e-8 Post bronchodilator FEV1; LUSC cis rs644148 0.748 rs542150 chr19:44967453 T/C cg15540054 chr19:45004280 ZNF180 0.46 6.28 0.33 1.03e-9 Personality dimensions; LUSC cis rs9400467 0.528 rs465796 chr6:111619725 T/G cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.25 -0.32 1.25e-9 Blood metabolite levels;Amino acid levels; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg07157834 chr1:205819609 PM20D1 0.85 15.28 0.64 2.52e-40 Menarche (age at onset); LUSC cis rs62458065 0.513 rs10268149 chr7:32575499 T/C cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.94 -0.31 7.2e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg22920501 chr2:26401640 FAM59B -0.73 -10.03 -0.48 7.45e-21 Gut microbiome composition (summer); LUSC cis rs9948 0.655 rs7568206 chr2:97393108 A/C cg01990225 chr2:97406019 LMAN2L -1.09 -8.15 -0.41 7.59e-15 Erectile dysfunction and prostate cancer treatment; LUSC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.83 -0.3 1.28e-8 Tonsillectomy; LUSC cis rs4474465 0.915 rs10899512 chr11:78171338 G/A cg27205649 chr11:78285834 NARS2 -0.49 -5.79 -0.3 1.61e-8 Alzheimer's disease (survival time); LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.18 0.45 4.55e-18 Prudent dietary pattern; LUSC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg19717773 chr7:2847554 GNA12 -0.38 -6.14 -0.32 2.29e-9 Height; LUSC cis rs701145 0.585 rs1470663 chr3:153870883 A/G cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.28 0.53 3.21e-25 Prudent dietary pattern; LUSC cis rs8027181 1.000 rs8027181 chr15:73088869 A/T cg25632853 chr15:73088954 NA 0.35 7.13 0.36 6.16e-12 Triglyceride levels; LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.9 0.48 2.05e-20 Bipolar disorder; LUSC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg00376283 chr12:123451042 ABCB9 0.68 8.54 0.42 4.8e-16 Neutrophil percentage of white cells; LUSC cis rs6580649 1.000 rs10783227 chr12:48400617 C/T cg24011408 chr12:48396354 COL2A1 0.53 7.38 0.37 1.27e-12 Lung cancer; LUSC cis rs7927592 0.913 rs7109294 chr11:68332093 A/G cg01657329 chr11:68192670 LRP5 -0.4 -5.87 -0.31 1.07e-8 Total body bone mineral density; LUSC cis rs17270561 0.636 rs9393671 chr6:25789189 G/C cg16482183 chr6:26056742 HIST1H1C -0.53 -7.53 -0.38 4.66e-13 Iron status biomarkers; LUSC trans rs6502050 0.835 rs9902485 chr17:80093701 C/T cg07393940 chr7:158741817 NA 0.38 6.86 0.35 3.29e-11 Life satisfaction; LUSC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg22823121 chr1:150693482 HORMAD1 0.49 7.0 0.36 1.37e-11 Melanoma; LUSC cis rs4285028 0.948 rs34543553 chr3:121675637 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.63 -0.47 1.55e-19 Multiple sclerosis; LUSC cis rs1878931 0.580 rs4578649 chr16:3407258 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.85 -16.35 -0.67 1.53e-44 Body mass index (adult); LUSC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg22800045 chr5:56110881 MAP3K1 0.82 10.17 0.49 2.35e-21 Initial pursuit acceleration; LUSC cis rs4948102 0.924 rs13240915 chr7:56090752 G/C cg17215666 chr7:56131930 SUMF2 0.48 6.22 0.32 1.48e-9 Plasma homocysteine levels (post-methionine load test); LUSC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11614622 chr11:66623681 LRFN4;PC 0.41 6.08 0.32 3.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1005277 0.579 rs1780136 chr10:38501453 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.5 -0.46 4.09e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7264396 0.635 rs6088971 chr20:34535373 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.82 -0.43 6.4e-17 Total cholesterol levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22091798 chr11:62446605 UBXN1 -0.44 -6.1 -0.32 2.96e-9 Hepatitis; LUSC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg22823121 chr1:150693482 HORMAD1 -0.61 -9.45 -0.46 6.14e-19 Tonsillectomy; LUSC trans rs3857536 0.842 rs2188590 chr6:66939534 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs7580658 0.929 rs2276583 chr2:128014684 G/A cg09760422 chr2:128146352 NA -0.32 -7.05 -0.36 1.02e-11 Protein C levels; LUSC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg04352962 chr1:209979756 IRF6 0.49 5.76 0.3 1.94e-8 Cleft lip with or without cleft palate; LUSC cis rs8017423 0.967 rs7160032 chr14:90708472 A/G cg14092571 chr14:90743983 NA -0.36 -5.99 -0.31 5.46e-9 Mortality in heart failure; LUSC cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs12137294 0.866 rs896320 chr1:205205347 T/C cg00857998 chr1:205179979 DSTYK 0.4 5.77 0.3 1.77e-8 Red cell distribution width; LUSC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg04121214 chr22:50244548 NA -0.34 -5.74 -0.3 2.14e-8 Schizophrenia; LUSC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg13902645 chr11:5959945 NA -0.58 -8.2 -0.41 5.23e-15 DNA methylation (variation); LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg12432903 chr7:1882776 MAD1L1 -0.36 -5.83 -0.3 1.27e-8 Bipolar disorder and schizophrenia; LUSC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg26958806 chr6:27640298 NA 0.66 5.66 0.3 3.22e-8 Depression; LUSC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.13 0.64 9.56e-40 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7647973 1.000 rs1464569 chr3:49460350 A/G cg07636037 chr3:49044803 WDR6 0.7 9.43 0.46 6.91e-19 Menarche (age at onset); LUSC cis rs500891 1.000 rs6910291 chr6:84185995 A/T cg08257003 chr6:84140564 ME1 0.34 7.02 0.36 1.26e-11 Platelet-derived growth factor BB levels; LUSC cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.76 -0.3 1.92e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs10791323 0.660 rs10791330 chr11:133727535 C/T cg00579200 chr11:133705235 NA -0.39 -5.92 -0.31 8.19e-9 Childhood ear infection; LUSC cis rs7605827 0.856 rs35549453 chr2:15527220 C/T cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg12927641 chr6:109611667 NA -0.34 -5.77 -0.3 1.81e-8 Reticulocyte fraction of red cells; LUSC cis rs62400317 0.859 rs17209741 chr6:45292438 A/T cg18551225 chr6:44695536 NA -0.41 -6.94 -0.36 2.01e-11 Total body bone mineral density; LUSC cis rs7100689 0.784 rs7081903 chr10:82162509 T/C cg01528321 chr10:82214614 TSPAN14 1.09 17.06 0.68 2.33e-47 Post bronchodilator FEV1; LUSC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg24562669 chr7:97807699 LMTK2 0.37 6.45 0.33 3.99e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs2236918 1.000 rs2526699 chr1:242022130 T/C cg17736920 chr1:242011382 EXO1 0.46 7.26 0.37 2.8e-12 Menopause (age at onset); LUSC cis rs4700695 0.719 rs27086 chr5:65453185 A/G cg21114390 chr5:65439923 SFRS12 -0.63 -8.98 -0.44 2.07e-17 Facial morphology (factor 19); LUSC cis rs10892173 0.765 rs1892903 chr11:117669619 A/G cg21640587 chr11:117668038 DSCAML1 0.35 5.73 0.3 2.2e-8 Myopia; LUSC cis rs17685 0.753 rs10251863 chr7:75790192 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg18404041 chr3:52824283 ITIH1 -0.56 -10.64 -0.5 6.05e-23 Bipolar disorder; LUSC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg12463550 chr7:65579703 CRCP -0.57 -8.62 -0.43 2.65e-16 Aortic root size; LUSC cis rs6762 0.719 rs4895 chr11:840477 A/G cg15787769 chr11:842744 TSPAN4;POLR2L -0.52 -7.1 -0.36 7.78e-12 Mean platelet volume; LUSC trans rs8072100 0.754 rs8081717 chr17:45653921 T/A cg03886242 chr7:26192032 NFE2L3 0.38 6.32 0.33 8.36e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs250677 0.916 rs17109279 chr5:148416581 A/G cg18129178 chr5:148520854 ABLIM3 -0.65 -10.24 -0.49 1.38e-21 Breast cancer; LUSC cis rs4356932 1.000 rs11097222 chr4:76987451 A/G cg00809888 chr4:76862425 NAAA 0.34 5.67 0.3 3.12e-8 Blood protein levels; LUSC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.67e-10 Lung cancer; LUSC cis rs193541 0.632 rs154504 chr5:122204086 A/T cg19077854 chr5:122220652 SNX24 0.42 8.48 0.42 7.62e-16 Glucose homeostasis traits; LUSC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg15557168 chr22:42548783 NA -0.47 -7.33 -0.37 1.73e-12 Schizophrenia; LUSC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.42 -0.38 9.62e-13 Height; LUSC cis rs11105298 0.786 rs10858897 chr12:89922032 C/A cg00757033 chr12:89920650 WDR51B 0.59 10.45 0.5 2.65e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.78 0.3 1.69e-8 Self-reported allergy; LUSC cis rs11864453 0.647 rs3852781 chr16:72123556 T/A cg01557791 chr16:72042693 DHODH -0.46 -6.84 -0.35 3.81e-11 Fibrinogen levels; LUSC cis rs8072100 0.701 rs8075566 chr17:45771037 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.38 -6.33 -0.33 8.04e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg04851639 chr8:1020857 NA -0.37 -7.85 -0.39 5.87e-14 Schizophrenia; LUSC cis rs709400 0.663 rs62007683 chr14:103894071 G/T cg12935359 chr14:103987150 CKB -0.57 -8.68 -0.43 1.73e-16 Body mass index; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg14159672 chr1:205819179 PM20D1 0.47 7.45 0.38 7.97e-13 Menarche (age at onset); LUSC cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg04455712 chr21:45112962 RRP1B 0.46 8.72 0.43 1.37e-16 Mean corpuscular volume; LUSC cis rs10089 1.000 rs2409109 chr5:127461471 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.99 0.55 8.74e-28 Ileal carcinoids; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg15242686 chr22:24348715 GSTTP1 -0.41 -6.04 -0.31 4.11e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12304921 0.639 rs2306732 chr12:51455739 G/T cg02675652 chr12:51477739 CSRNP2 -0.28 -5.8 -0.3 1.57e-8 Type 2 diabetes; LUSC cis rs11122272 0.735 rs2486736 chr1:231521478 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.64 10.04 0.48 6.8e-21 Hemoglobin concentration; LUSC cis rs4700695 0.841 rs152994 chr5:65262989 A/G cg21114390 chr5:65439923 SFRS12 0.49 5.64 0.3 3.56e-8 Facial morphology (factor 19); LUSC cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg24642844 chr7:1081250 C7orf50 -0.52 -7.9 -0.4 4.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs4794665 0.874 rs9908159 chr17:54841961 T/C cg18503679 chr3:21792543 ZNF385D 0.37 5.95 0.31 6.7e-9 Height; LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.844 rs1555330 chr20:25232097 A/C cg08601574 chr20:25228251 PYGB 0.55 8.83 0.43 6.23e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg24838063 chr12:130822603 PIWIL1 0.7 10.75 0.51 2.38e-23 Menopause (age at onset); LUSC cis rs9462027 0.606 rs2814984 chr6:34597513 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.03 -0.31 4.39e-9 Systemic lupus erythematosus; LUSC cis rs3806843 1.000 rs10072015 chr5:140170655 A/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.3 5.96 0.31 6.27e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs7769051 1.000 rs12204027 chr6:133122831 A/G cg07930552 chr6:133119739 C6orf192 0.84 10.61 0.5 7.57e-23 Type 2 diabetes nephropathy; LUSC trans rs1819054 0.806 rs1528351 chr7:121167875 C/T cg18897345 chr22:38885348 DDX17 -0.41 -6.17 -0.32 2.03e-9 Hand grip strength; LUSC cis rs9329221 0.686 rs35840352 chr8:10239807 A/G cg21775007 chr8:11205619 TDH 0.49 6.62 0.34 1.43e-10 Neuroticism; LUSC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg07211511 chr3:129823064 LOC729375 -0.62 -8.21 -0.41 4.72e-15 Blood pressure (smoking interaction); LUSC cis rs9399135 0.967 rs11755229 chr6:135369913 A/G cg22676075 chr6:135203613 NA 0.47 7.27 0.37 2.62e-12 Red blood cell count; LUSC cis rs9807989 0.507 rs2110659 chr2:103043867 G/A cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.92e-12 Asthma; LUSC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg05425664 chr17:57184151 TRIM37 0.52 7.8 0.39 8.19e-14 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg23758822 chr17:41437982 NA 0.87 16.08 0.66 1.68e-43 Menopause (age at onset); LUSC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg11062466 chr8:58055876 NA 0.68 7.85 0.39 5.73e-14 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg09034736 chr1:150693464 HORMAD1 0.44 6.11 0.32 2.79e-9 Melanoma; LUSC trans rs72674100 0.867 rs4615177 chr4:97963798 G/A cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.65 9.16 0.45 5.39e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs1577917 0.958 rs72907388 chr6:86440207 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.64 -9.06 -0.44 1.11e-17 Response to antipsychotic treatment; LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg19717773 chr7:2847554 GNA12 0.42 6.86 0.35 3.26e-11 Height; LUSC trans rs9944715 0.954 rs62096526 chr18:43745639 G/A cg01718231 chr17:29326311 RNF135 0.51 7.16 0.36 5.11e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs4356932 1.000 rs1554013 chr4:76933484 T/C cg00809888 chr4:76862425 NAAA 0.34 5.65 0.3 3.5e-8 Blood protein levels; LUSC cis rs6121246 0.567 rs7361893 chr20:30200751 C/T cg13852791 chr20:30311386 BCL2L1 0.73 8.39 0.42 1.35e-15 Mean corpuscular hemoglobin; LUSC cis rs7296418 0.961 rs10773921 chr12:123541606 C/T cg00376283 chr12:123451042 ABCB9 0.84 13.24 0.59 1.88e-32 Platelet count; LUSC cis rs6540559 0.543 rs650728 chr1:210433351 C/T cg22029157 chr1:209979665 IRF6 0.55 6.18 0.32 1.9e-9 Cleft lip with or without cleft palate; LUSC cis rs1451375 0.755 rs3829897 chr7:50629764 G/T cg18232548 chr7:50535776 DDC 0.53 8.01 0.4 1.91e-14 Malaria; LUSC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg21285383 chr16:89894308 SPIRE2 0.35 7.19 0.37 4.39e-12 Vitiligo; LUSC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg19622623 chr12:86230825 RASSF9 -0.43 -5.98 -0.31 5.85e-9 Major depressive disorder; LUSC cis rs10140922 0.966 rs28589517 chr14:35820643 G/A cg07166546 chr14:35805898 NA -0.25 -6.08 -0.32 3.24e-9 Hip circumference adjusted for BMI; LUSC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg05472934 chr7:22766657 IL6 0.5 7.76 0.39 1.03e-13 Lung cancer; LUSC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg06634786 chr22:41940651 POLR3H 0.49 5.72 0.3 2.34e-8 Vitiligo; LUSC cis rs17373728 0.739 rs6472896 chr8:76190315 A/C cg07016329 chr8:76221503 NA -0.49 -7.0 -0.36 1.44e-11 Diabetic kidney disease; LUSC cis rs546131 0.928 rs572690 chr11:34833614 A/G cg06937548 chr11:34938143 PDHX;APIP 0.49 7.0 0.36 1.41e-11 Lung disease severity in cystic fibrosis; LUSC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg02931644 chr1:25747376 RHCE 0.4 7.46 0.38 7.36e-13 Erythrocyte sedimentation rate; LUSC cis rs7091068 0.518 rs1543580 chr10:95446811 C/T cg20715218 chr10:95462985 C10orf4 0.51 6.47 0.33 3.4e-10 Urinary tract infection frequency; LUSC trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg25482853 chr8:67687455 SGK3 1.2 17.16 0.68 9.11e-48 Lung disease severity in cystic fibrosis; LUSC cis rs8141529 0.732 rs2347447 chr22:29179739 C/A cg02153584 chr22:29168773 CCDC117 0.66 10.72 0.51 3.16e-23 Lymphocyte counts; LUSC cis rs9625935 0.957 rs36606 chr22:30340410 A/T cg11564601 chr22:30592435 NA 0.38 5.66 0.3 3.18e-8 Tonsillectomy; LUSC cis rs9302635 0.513 rs12444701 chr16:72155240 C/T cg01557791 chr16:72042693 DHODH -0.47 -6.05 -0.31 3.94e-9 Blood protein levels; LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs7617480 0.648 rs9882443 chr3:48749064 G/A cg21141812 chr3:48556323 PFKFB4 0.35 6.24 0.32 1.32e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1348850 0.514 rs4893974 chr2:178497026 A/G cg27490568 chr2:178487706 NA 0.45 6.45 0.33 3.99e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.83 -0.35 4.11e-11 Crohn's disease; LUSC cis rs1891275 0.515 rs11186666 chr10:93477919 T/C cg07889827 chr10:93443413 NA -0.38 -8.53 -0.42 5.08e-16 Intelligence (multi-trait analysis); LUSC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg03806693 chr22:41940476 POLR3H 1.0 14.26 0.62 2.35e-36 Crohn's disease;Inflammatory bowel disease; LUSC cis rs929596 0.564 rs2741029 chr2:234530160 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -6.4 -0.33 5.13e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg11657440 chr19:46296263 DMWD -0.73 -11.2 -0.52 6.19e-25 Coronary artery disease; LUSC cis rs9486719 1.000 rs3798289 chr6:97023632 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.98 -0.48 1.1e-20 Migraine;Coronary artery disease; LUSC cis rs7091068 0.550 rs7079013 chr10:95487878 A/C cg20715218 chr10:95462985 C10orf4 0.66 9.35 0.46 1.29e-18 Urinary tract infection frequency; LUSC cis rs6500395 0.962 rs1115759 chr16:48599530 A/G cg04672837 chr16:48644449 N4BP1 0.42 6.01 0.31 4.91e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg00129232 chr17:37814104 STARD3 -0.5 -7.49 -0.38 6.21e-13 Asthma; LUSC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg09555818 chr19:45449301 APOC2 0.47 8.77 0.43 9.14e-17 Blood protein levels; LUSC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg11752832 chr7:134001865 SLC35B4 0.56 8.8 0.43 7.57e-17 Mean platelet volume; LUSC cis rs4474465 1.000 rs10899505 chr11:78165343 T/C cg27205649 chr11:78285834 NARS2 -0.49 -5.91 -0.31 8.5e-9 Alzheimer's disease (survival time); LUSC cis rs4076764 0.801 rs4571944 chr1:163367975 T/C cg24596788 chr1:163392923 NA -0.39 -6.69 -0.34 9.69e-11 Motion sickness; LUSC trans rs11088226 0.681 rs11700671 chr21:33938621 T/A cg09050820 chr6:167586206 TCP10L2 0.73 9.47 0.46 5.31e-19 Gastritis; LUSC cis rs7617480 0.549 rs9879978 chr3:48846600 T/G cg21141812 chr3:48556323 PFKFB4 0.33 5.74 0.3 2.13e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1994135 0.630 rs11052760 chr12:33724949 A/T cg06521331 chr12:34319734 NA -0.4 -5.76 -0.3 1.87e-8 Resting heart rate; LUSC trans rs208520 0.690 rs1233103 chr6:66855943 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.75 -0.68 3.68e-46 Exhaled nitric oxide output; LUSC cis rs981844 0.796 rs17030437 chr4:154704225 A/C cg14289246 chr4:154710475 SFRP2 -0.45 -5.89 -0.31 9.63e-9 Response to statins (LDL cholesterol change); LUSC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 6.84 0.35 3.84e-11 Bipolar disorder; LUSC cis rs9650315 0.789 rs13261678 chr8:57188333 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg13397359 chr6:42928475 GNMT 0.43 5.9 0.31 8.84e-9 Blood protein levels; LUSC trans rs62238980 0.614 rs77324143 chr22:32401957 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.01 -0.31 4.82e-9 Childhood ear infection; LUSC cis rs9527 0.590 rs7092029 chr10:104823909 A/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.62 -0.34 1.42e-10 Arsenic metabolism; LUSC cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -8.04 -0.4 1.62e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs372883 0.648 rs15092 chr21:30718201 G/A cg24692254 chr21:30365293 RNF160 -0.7 -10.59 -0.5 8.99e-23 Pancreatic cancer; LUSC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.46 -7.27 -0.37 2.59e-12 Bipolar disorder; LUSC cis rs4786125 0.516 rs7203888 chr16:6915483 T/C cg03623568 chr16:6915990 A2BP1 -0.49 -8.16 -0.41 7.04e-15 Heart rate variability traits (SDNN); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22380059 chr17:33307512 LIG3 -0.4 -6.06 -0.31 3.77e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7103648 1.000 rs12292911 chr11:47449072 C/T cg20307385 chr11:47447363 PSMC3 0.98 19.07 0.72 2.26e-55 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs4919087 1.000 rs7078288 chr10:99086361 C/T cg25902810 chr10:99078978 FRAT1 -0.47 -6.78 -0.35 5.5e-11 Monocyte count; LUSC cis rs10193935 0.818 rs10221927 chr2:42546680 A/C cg27598129 chr2:42591480 NA -0.63 -8.81 -0.43 6.7e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs4363385 0.818 rs559236 chr1:153010510 T/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg22875332 chr1:76189707 ACADM 0.77 10.32 0.49 7.56e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs3096299 0.504 rs4785574 chr16:89568875 A/G cg00750074 chr16:89608354 SPG7 -0.53 -9.57 -0.46 2.41e-19 Multiple myeloma (IgH translocation); LUSC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.43 -0.42 1.08e-15 Lung cancer; LUSC cis rs28655083 0.529 rs285022 chr16:77099730 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.38 6.15 0.32 2.24e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs262150 0.530 rs2730232 chr7:158784469 C/T cg22153799 chr7:158819822 NA -0.33 -5.77 -0.3 1.83e-8 Facial morphology (factor 20); LUSC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg07741184 chr6:167504864 NA 0.36 6.42 0.33 4.61e-10 Crohn's disease; LUSC cis rs11098499 0.954 rs17006190 chr4:120418838 C/G cg09307838 chr4:120376055 NA 0.78 11.53 0.53 4.06e-26 Corneal astigmatism; LUSC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg19046167 chr17:80928561 B3GNTL1 0.5 7.08 0.36 8.79e-12 Glycated hemoglobin levels; LUSC cis rs28647808 0.881 rs28461467 chr9:136261288 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg11301795 chr4:187892539 NA -0.86 -17.21 -0.69 5.96e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs950776 0.642 rs61630816 chr15:78965866 T/C cg06917634 chr15:78832804 PSMA4 0.49 6.81 0.35 4.58e-11 Sudden cardiac arrest; LUSC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg03264133 chr6:25882463 NA -0.39 -6.82 -0.35 4.2e-11 Height; LUSC cis rs4588572 0.601 rs10070202 chr5:77792462 A/C cg11547950 chr5:77652471 NA -0.59 -8.31 -0.41 2.44e-15 Triglycerides; LUSC cis rs62408225 0.962 rs1604830 chr6:90969221 T/C cg06866423 chr6:90926672 BACH2 0.41 5.85 0.31 1.15e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs3736485 0.934 rs4775955 chr15:51873449 C/T cg09125779 chr4:57547999 HOPX -0.34 -6.01 -0.31 4.96e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs208520 0.661 rs207099 chr6:66796373 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -17.09 -0.68 1.69e-47 Exhaled nitric oxide output; LUSC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg26335602 chr6:28129616 ZNF389 -0.45 -6.19 -0.32 1.74e-9 Depression; LUSC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg25456477 chr12:86230367 RASSF9 0.43 7.44 0.38 8.43e-13 Major depressive disorder; LUSC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg08847533 chr14:75593920 NEK9 -0.78 -13.21 -0.59 2.4e-32 Height; LUSC cis rs7605827 0.930 rs918157 chr2:15657729 G/A cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg16230307 chr14:35515116 FAM177A1 0.81 10.3 0.49 8.93e-22 Psoriasis; LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.15 0.52 8.96e-25 Prudent dietary pattern; LUSC cis rs757278 0.591 rs1800136 chr7:117307108 G/A cg10524701 chr7:117356490 CTTNBP2 0.4 5.76 0.3 1.9e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs6545883 0.929 rs2592352 chr2:61665336 C/T cg15711740 chr2:61764176 XPO1 -0.46 -7.12 -0.36 6.47e-12 Tuberculosis; LUSC cis rs8141797 0.901 rs176161 chr22:24516291 C/T cg00411358 chr22:24577142 SUSD2 -0.61 -6.07 -0.32 3.43e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs3125734 0.633 rs6479792 chr10:63983264 T/G cg19640130 chr10:64028056 RTKN2 -0.4 -7.07 -0.36 8.92e-12 Rheumatoid arthritis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08334199 chr2:178128998 NFE2L2 -0.4 -5.96 -0.31 6.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg08798685 chr6:27730294 NA -0.64 -6.01 -0.31 4.93e-9 Breast cancer; LUSC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.42 -6.52 -0.34 2.6200000000000003e-10 Bipolar disorder; LUSC cis rs11597390 0.865 rs12781812 chr10:101891222 G/T cg02250046 chr10:101825185 CPN1 -0.33 -6.0 -0.31 5.04e-9 Liver enzyme levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04900785 chr2:44589279 PREPL;C2orf34 0.41 5.96 0.31 6.52e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.818 rs3795382 chr1:153004853 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.46e-8 Inflammatory skin disease; LUSC trans rs1927790 0.727 rs9556550 chr13:96947034 A/C cg03198741 chr6:1003969 LOC285768 -0.4 -6.09 -0.32 3.08e-9 Body mass index; LUSC cis rs12541635 0.932 rs1835267 chr8:107044435 C/T cg10147462 chr8:107024639 NA 0.55 9.92 0.48 1.72e-20 Age of smoking initiation; LUSC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg17366294 chr4:99064904 C4orf37 0.56 9.92 0.48 1.69e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs11148252 0.574 rs7139495 chr13:53283318 A/G cg02158880 chr13:53174818 NA 0.57 9.84 0.47 3.16e-20 Lewy body disease; LUSC cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg06784218 chr1:46089804 CCDC17 0.48 9.47 0.46 5.16e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3936840 1.000 rs3936840 chr14:102984274 G/C cg18135206 chr14:102964638 TECPR2 0.59 8.82 0.43 6.42e-17 Plateletcrit; LUSC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg09877947 chr5:131593287 PDLIM4 0.46 7.56 0.38 3.84e-13 Breast cancer; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg17541715 chr7:1216824 NA -0.43 -6.58 -0.34 1.78e-10 Longevity;Endometriosis; LUSC cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg04267008 chr7:1944627 MAD1L1 0.59 9.0 0.44 1.75e-17 Bipolar disorder and schizophrenia; LUSC cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.36 -0.37 1.48e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.43e-34 Diabetic kidney disease; LUSC cis rs1949733 0.523 rs55977448 chr4:8542918 G/T cg13073564 chr4:8508604 NA 0.36 6.53 0.34 2.5e-10 Response to antineoplastic agents; LUSC cis rs9300255 0.722 rs28592876 chr12:123866429 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 5.74 0.3 2.12e-8 Neutrophil percentage of white cells; LUSC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg22307029 chr19:49891270 CCDC155 0.62 7.96 0.4 2.64e-14 Multiple sclerosis; LUSC cis rs11583043 1.000 rs34915449 chr1:101476786 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.74 0.3 2.08e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs314370 0.951 rs12705092 chr7:100473550 G/A cg10426581 chr7:100472382 SRRT 0.86 12.47 0.56 1.43e-29 Resting heart rate; LUSC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg26314531 chr2:26401878 FAM59B -0.71 -9.41 -0.46 8.43e-19 Gut microbiome composition (summer); LUSC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg09365446 chr1:150670422 GOLPH3L 0.48 7.21 0.37 3.71e-12 Melanoma; LUSC cis rs9467711 0.606 rs9348712 chr6:26366511 T/A cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg24675658 chr1:53192096 ZYG11B -0.7 -11.79 -0.54 4.52e-27 Monocyte count; LUSC cis rs13392177 0.684 rs6720105 chr2:219080718 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.39 -5.73 -0.3 2.23e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.69 0.39 1.63e-13 Prudent dietary pattern; LUSC trans rs11098499 0.863 rs11736416 chr4:120431661 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.61 0.34 1.48e-10 Corneal astigmatism; LUSC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg16447950 chr5:562315 NA -0.58 -7.3 -0.37 2.1e-12 Obesity-related traits; LUSC cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg15212455 chr7:39170539 POU6F2 0.59 9.42 0.46 7.64e-19 IgG glycosylation; LUSC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg23630131 chr7:65973040 NA 0.21 5.79 0.3 1.6e-8 Aortic root size; LUSC cis rs4363385 0.667 rs78426057 chr1:152964528 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.55 -0.38 4.06e-13 Inflammatory skin disease; LUSC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs131777 0.576 rs131758 chr22:51017082 T/A cg00083937 chr22:51039805 MAPK8IP2 0.56 9.56 0.46 2.6e-19 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9443189 0.615 rs602873 chr6:76323818 T/A cg01950844 chr6:76311363 SENP6 0.7 7.02 0.36 1.26e-11 Prostate cancer; LUSC cis rs1018836 0.700 rs7824511 chr8:91521545 T/C cg16814680 chr8:91681699 NA -0.73 -11.41 -0.53 1.05e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4595586 0.545 rs1375796 chr12:39410592 G/T cg13010199 chr12:38710504 ALG10B 0.45 6.38 0.33 5.87e-10 Morning vs. evening chronotype; LUSC cis rs8114671 0.839 rs2104084 chr20:33649217 G/C cg07148914 chr20:33460835 GGT7 -0.46 -6.8 -0.35 4.88e-11 Height; LUSC cis rs36093844 0.752 rs80193798 chr11:85577529 C/T cg25872744 chr11:85566296 CCDC83 -0.45 -5.88 -0.31 1.01e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg08219700 chr8:58056026 NA 0.43 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); LUSC cis rs13392177 0.637 rs61041183 chr2:219056380 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.41 6.06 0.31 3.65e-9 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -7.89 -0.4 4.31e-14 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2985684 0.894 rs4900927 chr14:50018741 G/T cg04989706 chr14:50066350 PPIL5 -0.46 -6.28 -0.33 1.04e-9 Carotid intima media thickness; LUSC cis rs9888739 0.920 rs12102768 chr16:31303950 G/A cg15817542 chr16:31343056 ITGAM -0.5 -6.05 -0.31 3.93e-9 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg03676636 chr4:99064102 C4orf37 0.37 8.12 0.41 9.37e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg07777115 chr5:623756 CEP72 -0.45 -5.7 -0.3 2.62e-8 Obesity-related traits; LUSC cis rs1595825 0.891 rs1030796 chr2:198674673 A/G cg00982548 chr2:198649783 BOLL -0.6 -7.44 -0.38 8.52e-13 Ulcerative colitis; LUSC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg22903471 chr2:27725779 GCKR -0.4 -6.79 -0.35 5.14e-11 Total body bone mineral density; LUSC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg03563238 chr19:33554763 RHPN2 -0.35 -6.04 -0.31 4.03e-9 Bone properties (heel); LUSC cis rs1023500 0.529 rs133375 chr22:42466509 C/G cg04733989 chr22:42467013 NAGA 0.61 9.3 0.45 1.92e-18 Schizophrenia; LUSC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg11812906 chr14:75593930 NEK9 0.66 11.25 0.52 3.96e-25 Height; LUSC cis rs9303401 0.573 rs34717648 chr17:56886624 T/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.7 0.6 3.15e-34 Cognitive test performance; LUSC cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg23649088 chr2:200775458 C2orf69 -0.53 -6.82 -0.35 4.37e-11 Schizophrenia; LUSC cis rs67696533 0.600 rs910891 chr20:31111505 G/C cg13636640 chr20:31349939 DNMT3B 0.47 6.21 0.32 1.55e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs11039798 0.588 rs10838979 chr11:48626810 T/G cg03929089 chr4:120376271 NA 0.59 6.44 0.33 4.04e-10 Axial length; LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.65 0.34 1.2e-10 Obesity-related traits; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.53 0.38 4.69e-13 Bipolar disorder; LUSC cis rs9715521 0.677 rs4490528 chr4:59854572 T/G cg11281224 chr4:60001000 NA -0.5 -7.02 -0.36 1.25e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03278965 chr3:141595308 ATP1B3 0.4 6.03 0.31 4.41e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.85 0.54 2.8e-27 Prudent dietary pattern; LUSC cis rs9322193 0.886 rs4870049 chr6:150158194 G/T cg13206674 chr6:150067644 NUP43 0.55 8.45 0.42 9.43e-16 Lung cancer; LUSC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg15352829 chr14:105391018 PLD4 -0.35 -7.35 -0.37 1.51e-12 Rheumatoid arthritis; LUSC cis rs9039 0.921 rs9929699 chr16:9218270 A/G cg08831531 chr16:9218945 NA -0.54 -8.58 -0.43 3.59e-16 Menopause (age at onset); LUSC cis rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05901451 chr6:126070800 HEY2 -0.78 -14.11 -0.61 8.68e-36 Brugada syndrome; LUSC cis rs981844 1.000 rs1116636 chr4:154657151 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg00409905 chr10:38381863 ZNF37A 0.37 6.32 0.33 8.2e-10 Extrinsic epigenetic age acceleration; LUSC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.7 -0.39 1.58e-13 Height; LUSC trans rs9291683 0.588 rs3796829 chr4:10019138 C/G cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Bone mineral density; LUSC cis rs950776 0.518 rs12915428 chr15:78823368 G/A cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg05420251 chr10:102133820 C10orf75 0.44 6.44 0.33 4.25e-10 Mosquito bite size; LUSC cis rs4820539 0.966 rs2267001 chr22:23456696 T/C cg14186256 chr22:23484241 RTDR1 0.9 16.12 0.66 1.15e-43 Bone mineral density; LUSC cis rs61931739 0.892 rs61931711 chr12:34045374 C/T cg06521331 chr12:34319734 NA 0.4 6.61 0.34 1.48e-10 Morning vs. evening chronotype; LUSC cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg01028140 chr2:1542097 TPO -0.61 -8.17 -0.41 6.41e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg21770322 chr7:97807741 LMTK2 -0.4 -7.0 -0.36 1.37e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs10197940 0.578 rs2045025 chr2:152317531 T/C cg06191203 chr2:152266755 RIF1 -0.42 -5.73 -0.3 2.2e-8 Lung cancer; LUSC cis rs11864453 0.826 rs9941087 chr16:72118324 G/A cg16558253 chr16:72132732 DHX38 -0.41 -6.26 -0.32 1.19e-9 Fibrinogen levels; LUSC cis rs9326248 0.581 rs6589590 chr11:116936081 A/C cg11861562 chr11:117069780 TAGLN 0.33 6.38 0.33 5.8e-10 Blood protein levels; LUSC cis rs7020830 0.522 rs10814509 chr9:37111057 A/G cg14294708 chr9:37120828 ZCCHC7 0.66 11.35 0.53 1.82e-25 Schizophrenia; LUSC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg08847533 chr14:75593920 NEK9 0.85 15.78 0.65 2.64e-42 Height; LUSC cis rs13202913 0.709 rs11965449 chr6:151830598 C/T cg10883421 chr6:151773342 RMND1;C6orf211 -0.52 -5.88 -0.31 9.95e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs9467711 0.675 rs58825580 chr6:26365679 T/G cg09904177 chr6:26538194 HMGN4 -0.65 -6.27 -0.32 1.14e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg26061582 chr7:22766209 IL6 0.52 7.63 0.39 2.56e-13 Lung cancer; LUSC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.37 -0.33 6.14e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12210905 0.925 rs72838228 chr6:26945920 C/T cg23155468 chr6:27110703 HIST1H2BK -0.67 -5.96 -0.31 6.27e-9 Hip circumference adjusted for BMI; LUSC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg06558623 chr16:89946397 TCF25 1.11 9.73 0.47 7.08e-20 Skin colour saturation; LUSC cis rs10207060 0.500 rs10177457 chr2:240708067 G/A cg20333904 chr2:240724165 NA -0.36 -6.12 -0.32 2.56e-9 Obesity-related traits; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G ch.5.67026991F chr5:66991235 NA 0.41 6.46 0.33 3.7e-10 Schizophrenia; LUSC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg11211951 chr8:145729740 GPT 0.45 8.28 0.41 3.08e-15 Age at first birth; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg01238044 chr22:24384105 GSTT1 -0.52 -7.58 -0.38 3.51e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs61931739 0.793 rs609886 chr12:34138160 T/G cg06521331 chr12:34319734 NA -0.37 -6.18 -0.32 1.88e-9 Morning vs. evening chronotype; LUSC trans rs75804782 0.641 rs72987304 chr2:239345532 C/T cg01134436 chr17:81009848 B3GNTL1 0.66 6.08 0.32 3.31e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg27535305 chr1:53392650 SCP2 -0.4 -7.43 -0.38 9.16e-13 Monocyte count; LUSC cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14240646 chr10:27532245 ACBD5 -0.91 -8.4 -0.42 1.29e-15 Breast cancer; LUSC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg04362960 chr10:104952993 NT5C2 -0.61 -9.36 -0.46 1.19e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6930083 0.605 rs3829964 chr6:36644498 T/C cg08179530 chr6:36648295 CDKN1A 0.61 8.77 0.43 9.24e-17 Coronary artery disease; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg11494091 chr17:61959527 GH2 0.63 13.47 0.59 2.59e-33 Prudent dietary pattern; LUSC cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg22875332 chr1:76189707 ACADM -0.41 -6.07 -0.32 3.39e-9 Daytime sleep phenotypes; LUSC cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.93 0.35 2.15e-11 Multiple sclerosis; LUSC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg22834771 chr12:69754056 YEATS4 -0.56 -8.33 -0.41 2.1e-15 Cerebrospinal fluid biomarker levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02862674 chr6:44238426 TMEM151B -0.45 -5.97 -0.31 6.12e-9 Bipolar disorder and schizophrenia; LUSC cis rs3947 1.000 rs3947 chr8:11702375 G/A cg00262122 chr8:11665843 FDFT1 -0.5 -6.0 -0.31 5.13e-9 Blood protein levels; LUSC cis rs12410462 0.581 rs77430808 chr1:227540880 C/T cg10327440 chr1:227177885 CDC42BPA -0.66 -6.56 -0.34 2.09e-10 Major depressive disorder; LUSC cis rs7582720 0.943 rs115827549 chr2:203725678 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1153858 1.000 rs2461701 chr15:45703391 G/A cg21132104 chr15:45694354 SPATA5L1 0.56 7.77 0.39 1.01e-13 Homoarginine levels; LUSC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs12701220 0.744 rs35588238 chr7:1012006 G/A cg26769984 chr7:1090371 C7orf50 0.46 6.64 0.34 1.27e-10 Bronchopulmonary dysplasia; LUSC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg05855489 chr10:104503620 C10orf26 0.59 9.39 0.46 9.82e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs3812831 0.695 rs10467349 chr13:114939441 A/G cg15896084 chr13:114927664 NA 0.38 6.85 0.35 3.46e-11 Schizophrenia; LUSC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg13206674 chr6:150067644 NUP43 0.5 7.82 0.39 7.16e-14 Lung cancer; LUSC cis rs11153730 0.503 rs283046 chr6:118627503 T/C cg21191810 chr6:118973309 C6orf204 0.34 5.72 0.3 2.35e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); LUSC cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.75 0.35 6.45e-11 Height; LUSC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.41 5.74 0.3 2.16e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2295359 0.892 rs12401432 chr1:67656931 C/G cg03340356 chr1:67600835 NA 0.44 6.77 0.35 5.75e-11 Psoriasis; LUSC cis rs12540874 0.698 rs3823674 chr7:50571996 C/T cg18232548 chr7:50535776 DDC -0.58 -8.67 -0.43 1.88e-16 Systemic sclerosis; LUSC cis rs3771570 0.901 rs62190410 chr2:242410621 C/T cg21155796 chr2:242212141 HDLBP 0.61 6.86 0.35 3.35e-11 Prostate cancer; LUSC cis rs9653442 0.545 rs12712067 chr2:100763900 A/C cg22139774 chr2:100720529 AFF3 0.41 6.78 0.35 5.51e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4654899 0.802 rs6426648 chr1:21179527 A/G cg01072550 chr1:21505969 NA -0.47 -7.08 -0.36 8.56e-12 Superior frontal gyrus grey matter volume; LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg08470875 chr2:26401718 FAM59B 0.71 9.74 0.47 6.55e-20 Gut microbiome composition (summer); LUSC cis rs17095355 0.901 rs12572168 chr10:111764786 A/C cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.12 -0.36 6.69e-12 Biliary atresia; LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg27170947 chr2:26402098 FAM59B 0.71 10.96 0.51 4.41e-24 Gut microbiome composition (summer); LUSC cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs5769707 0.872 rs5770604 chr22:50030672 G/A cg20744362 chr22:50050164 C22orf34 0.38 7.93 0.4 3.42e-14 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg15147215 chr3:52552868 STAB1 0.35 6.86 0.35 3.35e-11 Electroencephalogram traits; LUSC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg09365446 chr1:150670422 GOLPH3L 0.49 7.17 0.37 4.8e-12 Melanoma; LUSC cis rs7804356 1.000 rs3801842 chr7:26830263 C/T cg03456212 chr7:26904342 SKAP2 -0.56 -6.62 -0.34 1.47e-10 Type 1 diabetes; LUSC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg24675056 chr1:15929824 NA -0.41 -7.1 -0.36 7.46e-12 Systolic blood pressure; LUSC cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg23711669 chr6:146136114 FBXO30 0.9 16.97 0.68 5.1e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg05340658 chr4:99064831 C4orf37 0.68 11.35 0.53 1.73e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg21775007 chr8:11205619 TDH -0.42 -6.33 -0.33 8e-10 Neuroticism; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg16606324 chr3:10149918 C3orf24 0.58 8.44 0.42 1e-15 Alzheimer's disease; LUSC cis rs1696756 0.638 rs1290396 chr17:77830767 C/T cg00646381 chr17:77835854 NA 0.6 9.75 0.47 6.38e-20 Glucocorticoid-induced osteonecrosis (age 10 years and older); LUSC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg00784671 chr22:46762841 CELSR1 -0.54 -6.94 -0.35 2.07e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs9300255 0.679 rs28583837 chr12:123863620 G/A cg00376283 chr12:123451042 ABCB9 -0.66 -7.39 -0.37 1.2e-12 Neutrophil percentage of white cells; LUSC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg09655341 chr17:79618100 PDE6G -0.28 -6.36 -0.33 6.81e-10 Eye color traits; LUSC cis rs4144743 0.702 rs7208055 chr17:45330827 C/A cg18085866 chr17:45331354 ITGB3 -0.71 -6.85 -0.35 3.57e-11 Body mass index; LUSC cis rs782590 0.764 rs935177 chr2:55826761 C/G cg03859395 chr2:55845619 SMEK2 0.81 14.18 0.61 4.69e-36 Metabolic syndrome; LUSC cis rs9815354 0.812 rs73081383 chr3:41920614 A/G cg03022575 chr3:42003672 ULK4 0.83 8.57 0.42 3.85e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7523050 0.643 rs35526993 chr1:109405107 A/T cg08274380 chr1:109419600 GPSM2 1.07 10.65 0.5 5.34e-23 Fat distribution (HIV); LUSC cis rs2404602 0.647 rs3812909 chr15:77176200 A/T cg23625390 chr15:77176239 SCAPER -0.65 -10.12 -0.48 3.65e-21 Blood metabolite levels; LUSC cis rs4820539 1.000 rs885964 chr22:23461003 G/C cg21100191 chr22:23484243 RTDR1 0.92 15.74 0.65 3.76e-42 Bone mineral density; LUSC cis rs9682041 0.877 rs9682908 chr3:170072010 C/T cg11886554 chr3:170076028 SKIL 0.69 8.54 0.42 4.81e-16 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs7577696 0.568 rs177082 chr2:32438350 A/T cg02381751 chr2:32503542 YIPF4 0.53 6.84 0.35 3.76e-11 Inflammatory biomarkers; LUSC cis rs11190604 1.000 rs11190592 chr10:102291059 T/C cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.26e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6964587 1.000 rs6465343 chr7:91618208 T/C cg01689657 chr7:91764605 CYP51A1 0.31 5.71 0.3 2.55e-8 Breast cancer; LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg00945038 chr17:61921165 SMARCD2 -0.52 -8.86 -0.44 4.88e-17 Prudent dietary pattern; LUSC cis rs6489882 0.867 rs6489874 chr12:113367895 A/G cg20102336 chr12:113376681 OAS3 -0.4 -5.74 -0.3 2.17e-8 Chronic lymphocytic leukemia; LUSC trans rs1994135 0.586 rs7308214 chr12:33713834 T/A cg26384229 chr12:38710491 ALG10B 0.66 9.51 0.46 3.77e-19 Resting heart rate; LUSC cis rs73198271 0.565 rs575920 chr8:8594254 C/T cg01851573 chr8:8652454 MFHAS1 0.41 6.28 0.33 1.04e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs72781680 1.000 rs72781631 chr2:24195064 G/A cg20701182 chr2:24300061 SF3B14 0.57 6.11 0.32 2.75e-9 Lymphocyte counts; LUSC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg16339924 chr4:17578868 LAP3 0.59 9.27 0.45 2.45e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.94 -0.36 2.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4906332 1.000 rs3783400 chr14:103967045 G/A cg04998671 chr14:104000505 TRMT61A -0.48 -7.63 -0.39 2.42e-13 Coronary artery disease; LUSC cis rs10465746 0.967 rs11163868 chr1:84397013 T/G cg10977910 chr1:84465055 TTLL7 0.44 6.42 0.33 4.58e-10 Obesity-related traits; LUSC cis rs12760731 0.623 rs6701584 chr1:178290509 C/T cg00404053 chr1:178313656 RASAL2 0.48 5.93 0.31 7.58e-9 Obesity-related traits; LUSC cis rs6845621 0.745 rs7356391 chr4:18865600 C/T cg12196642 chr4:18937545 NA -0.32 -5.94 -0.31 7.15e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs11785400 0.793 rs4336593 chr8:143739647 A/C cg10596483 chr8:143751796 JRK -0.52 -7.52 -0.38 5.08e-13 Schizophrenia; LUSC cis rs2629540 0.889 rs10901815 chr10:126435598 G/A cg08799069 chr10:126477246 METTL10 -0.68 -10.11 -0.48 3.87e-21 Cocaine dependence; LUSC cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg11266682 chr4:10021025 SLC2A9 -0.45 -7.69 -0.39 1.72e-13 Bone mineral density; LUSC cis rs6754311 0.773 rs309137 chr2:136765951 A/G cg07169764 chr2:136633963 MCM6 0.51 6.99 0.36 1.51e-11 Mosquito bite size; LUSC cis rs10193935 0.901 rs10200353 chr2:42509554 A/G cg27598129 chr2:42591480 NA -0.64 -8.69 -0.43 1.65e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1011108 0.561 rs1053807 chr2:26800422 G/A cg18742855 chr2:26800399 C2orf70 0.53 10.31 0.49 8.17e-22 Periodontal microbiota; LUSC cis rs9517313 0.592 rs61969458 chr13:99177633 A/G cg07423050 chr13:99094983 FARP1 -0.55 -9.98 -0.48 1.09e-20 Neuroticism; LUSC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -8.34 -0.42 1.94e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9815354 1.000 rs56158380 chr3:41885588 G/A cg03022575 chr3:42003672 ULK4 0.64 7.02 0.36 1.21e-11 Pulse pressure;Diastolic blood pressure; LUSC trans rs10411161 0.752 rs10404812 chr19:52400691 T/C cg22319618 chr22:45562946 NUP50 -0.55 -6.18 -0.32 1.82e-9 Breast cancer; LUSC cis rs6058796 1.000 rs35220493 chr20:31267831 G/A cg13636640 chr20:31349939 DNMT3B 0.54 5.75 0.3 1.99e-8 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg13433942 chr9:4679784 CDC37L1 0.47 6.09 0.32 3.12e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4595586 0.545 rs17546137 chr12:39401124 G/A cg26384229 chr12:38710491 ALG10B 0.52 7.35 0.37 1.52e-12 Morning vs. evening chronotype; LUSC trans rs11992162 0.613 rs6601634 chr8:11806456 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.07 -0.32 3.54e-9 Monocyte count; LUSC trans rs9296949 1.000 rs6939631 chr6:14572428 C/T cg00081417 chr6:140400137 NA 0.58 6.2 0.32 1.68e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.66 -0.3 3.26e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg03676636 chr4:99064102 C4orf37 0.36 8.06 0.4 1.33e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.935 rs380883 chr6:145822992 A/G cg05347473 chr6:146136440 FBXO30 0.46 7.7 0.39 1.51e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg00484396 chr16:3507460 NAT15 0.7 12.26 0.56 8.62e-29 Tuberculosis; LUSC cis rs5758511 0.680 rs739147 chr22:42671066 T/G cg00645731 chr22:42541494 CYP2D7P1 0.61 10.66 0.5 4.85e-23 Birth weight; LUSC cis rs7789940 0.904 rs12531348 chr7:75937191 G/C cg15798862 chr7:76129360 DTX2 -0.45 -7.15 -0.36 5.43e-12 Multiple sclerosis; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg18402987 chr7:1209562 NA 0.69 7.41 0.38 1.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg10172584 chr19:19639581 YJEFN3 -0.46 -5.68 -0.3 2.95e-8 Bipolar disorder; LUSC cis rs11955175 1.000 rs78426328 chr5:40673176 G/T cg04002187 chr5:40835754 RPL37 0.67 5.87 0.31 1.04e-8 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25622597 chr3:49449489 RHOA;TCTA 0.48 6.48 0.33 3.22e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg06873352 chr17:61820015 STRADA 0.7 12.55 0.57 7.07e-30 Prudent dietary pattern; LUSC cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.74 -0.35 7.14e-11 Monocyte percentage of white cells; LUSC trans rs970548 0.738 rs61854113 chr10:46004815 C/T cg20477318 chr10:51623047 TIMM23 0.59 6.02 0.31 4.5e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs1267303 0.642 rs3737740 chr1:47000596 G/A cg25110126 chr1:46999211 NA 0.78 11.16 0.52 8.32e-25 Monobrow; LUSC cis rs17401966 0.838 rs12120042 chr1:10345325 A/T cg19773385 chr1:10388646 KIF1B -0.48 -8.47 -0.42 7.64e-16 Hepatocellular carcinoma; LUSC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg05132306 chr1:1846340 CALML6 -0.35 -8.9 -0.44 3.61e-17 Body mass index; LUSC cis rs887829 0.569 rs3821242 chr2:234637803 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -8.15 -0.41 7.24e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg11941060 chr3:133502564 NA -0.51 -7.92 -0.4 3.5e-14 Iron status biomarkers; LUSC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg22903657 chr4:1355424 KIAA1530 -0.36 -5.96 -0.31 6.56e-9 Longevity; LUSC cis rs1878931 0.513 rs35160989 chr16:3405506 G/A cg00484396 chr16:3507460 NAT15 -0.38 -6.32 -0.33 8.23e-10 Body mass index (adult); LUSC cis rs7193541 0.684 rs4888262 chr16:74670458 C/T cg01733217 chr16:74700730 RFWD3 1.01 22.45 0.78 1.11e-68 Multiple myeloma; LUSC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg02187348 chr16:89574699 SPG7 0.64 10.93 0.51 5.63e-24 Multiple myeloma (IgH translocation); LUSC cis rs2652822 0.933 rs7170846 chr15:63449543 A/C cg02713581 chr15:63449717 RPS27L 0.43 6.72 0.35 7.69e-11 Metabolic traits; LUSC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg05368731 chr17:41323189 NBR1 0.92 15.94 0.66 5.93e-43 Menopause (age at onset); LUSC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.48 -0.33 3.22e-10 Lung cancer; LUSC cis rs1499972 0.941 rs62263122 chr3:117630669 T/C cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.95e-8 Schizophrenia; LUSC trans rs629535 0.748 rs689410 chr8:70037558 G/A cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg18451016 chr1:38461880 NA 0.41 6.26 0.32 1.16e-9 Coronary artery disease; LUSC cis rs453301 0.719 rs34004903 chr8:8892604 C/T cg15556689 chr8:8085844 FLJ10661 -0.61 -9.76 -0.47 5.91e-20 Joint mobility (Beighton score); LUSC cis rs77633900 0.772 rs284902 chr15:76745687 G/C cg21673338 chr15:77095150 SCAPER -0.68 -5.84 -0.3 1.22e-8 Non-glioblastoma glioma;Glioma; LUSC cis rs4363385 0.818 rs436621 chr1:153005492 A/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs9341808 0.754 rs6916405 chr6:81024188 C/T cg08355045 chr6:80787529 NA 0.56 9.73 0.47 7.43e-20 Sitting height ratio; LUSC cis rs11676348 0.741 rs12694425 chr2:218942313 A/G cg00012203 chr2:219082015 ARPC2 0.49 7.34 0.37 1.62e-12 Ulcerative colitis; LUSC cis rs7129727 1 rs7129727 chr11:57484660 G/A cg23127183 chr11:57508653 C11orf31 -0.53 -8.13 -0.41 8.55e-15 Autism spectrum disorder or schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15891076 chr10:65930618 NA -0.72 -6.16 -0.32 2.14e-9 Cognitive performance; LUSC cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg20891283 chr12:69753455 YEATS4 0.81 14.74 0.63 3.04e-38 Blood protein levels; LUSC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.44 -7.96 -0.4 2.67e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.14 0.64 8.26e-40 Platelet count; LUSC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg01503450 chr10:980765 NA -0.39 -5.77 -0.3 1.82e-8 Eosinophil percentage of granulocytes; LUSC cis rs877282 0.583 rs10904566 chr10:821662 C/G cg13775593 chr10:823151 NA 0.31 6.09 0.32 3.05e-9 Uric acid levels; LUSC cis rs7106204 0.748 rs7122986 chr11:24224634 G/A ch.11.24196551F chr11:24239977 NA 1.13 14.81 0.63 1.67e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7809950 0.678 rs2395869 chr7:106940098 C/A cg23024343 chr7:107201750 COG5 -0.66 -9.81 -0.47 3.95e-20 Coronary artery disease; LUSC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg21862992 chr11:68658383 NA 0.47 7.21 0.37 3.72e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs3931020 0.657 rs277368 chr1:75230606 C/T cg21535942 chr1:75199100 CRYZ;TYW3 -0.45 -5.65 -0.3 3.38e-8 Resistin levels; LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.52 -9.0 -0.44 1.73e-17 Prudent dietary pattern; LUSC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg12463550 chr7:65579703 CRCP 0.5 6.99 0.36 1.46e-11 Aortic root size; LUSC cis rs7795096 0.806 rs10277655 chr7:151540697 T/C cg17008978 chr7:151542804 PRKAG2 0.35 6.64 0.34 1.25e-10 Bipolar disorder (age of onset and psychotic symptoms); LUSC cis rs9287719 0.870 rs728135 chr2:10745132 A/C cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC trans rs7726558 0.731 rs73251672 chr5:118862735 T/C cg14402224 chr7:50570049 DDC -0.49 -6.5 -0.34 2.99e-10 QT interval (sulfonylurea treatment interaction); LUSC cis rs4654899 0.932 rs10916943 chr1:21472429 T/C cg02927042 chr1:21476669 EIF4G3 0.35 5.67 0.3 3.08e-8 Superior frontal gyrus grey matter volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15736296 chr11:57335454 UBE2L6 -0.43 -6.12 -0.32 2.69e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3007168 0.744 rs7147129 chr14:51640496 C/T cg23942311 chr14:51606299 NA -0.35 -6.31 -0.33 8.63e-10 Cancer; LUSC cis rs1461503 0.966 rs1461504 chr11:122845129 T/C cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg07507251 chr3:52567010 NT5DC2 0.34 6.74 0.35 7.17e-11 Bipolar disorder; LUSC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg22681709 chr2:178499509 PDE11A -0.57 -11.09 -0.52 1.47e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4588572 0.570 rs6453389 chr5:77727003 T/G cg11547950 chr5:77652471 NA -0.48 -7.24 -0.37 3.19e-12 Triglycerides; LUSC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg04998671 chr14:104000505 TRMT61A -0.44 -6.24 -0.32 1.35e-9 Reticulocyte count; LUSC cis rs3925075 0.584 rs12600286 chr16:31360679 G/C cg02846316 chr16:31340340 ITGAM 0.38 6.92 0.35 2.29e-11 IgA nephropathy; LUSC cis rs2361710 0.668 rs2304855 chr17:78118266 T/A cg09238746 chr17:78121135 EIF4A3 -0.65 -10.14 -0.49 3e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09047471 chr8:56792345 LYN 0.43 6.23 0.32 1.39e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg14552801 chr7:65878734 NA 0.37 5.66 0.3 3.2e-8 Aortic root size; LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.84 0.47 3.11e-20 Bipolar disorder; LUSC cis rs2073300 1.000 rs6137962 chr20:23443966 T/C cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18404041 chr3:52824283 ITIH1 -0.52 -10.19 -0.49 2.09e-21 Bipolar disorder; LUSC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg11301795 chr4:187892539 NA -0.81 -15.31 -0.64 1.86e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs7572733 0.534 rs734037 chr2:198749269 G/A cg00792783 chr2:198669748 PLCL1 0.46 6.15 0.32 2.17e-9 Dermatomyositis; LUSC cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.39 0.56 3e-29 Motion sickness; LUSC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg06637938 chr14:75390232 RPS6KL1 -0.51 -7.81 -0.39 7.53e-14 Height; LUSC cis rs79349575 0.681 rs56080003 chr17:47019049 A/T cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC cis rs9311676 0.618 rs12152336 chr3:58365146 T/A cg13750441 chr3:58318267 PXK 0.35 6.76 0.35 6.33e-11 Systemic lupus erythematosus; LUSC cis rs4132509 0.744 rs12031994 chr1:243917309 T/C cg21452805 chr1:244014465 NA 0.56 5.69 0.3 2.78e-8 RR interval (heart rate); LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs910316 0.737 rs91144 chr14:75449517 G/A cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.31 -0.37 2e-12 Height; LUSC trans rs7824557 0.564 rs2572400 chr8:11234367 T/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.84 -0.39 6.26e-14 Retinal vascular caliber; LUSC cis rs12760731 0.565 rs16852576 chr1:178192371 C/T cg00404053 chr1:178313656 RASAL2 0.66 6.86 0.35 3.32e-11 Obesity-related traits; LUSC cis rs73416724 1.000 rs70953680 chr6:43267831 G/A cg26312998 chr6:43337775 ZNF318 0.56 6.32 0.33 8.29e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs36093844 0.752 rs17744675 chr11:85593906 C/T cg25872744 chr11:85566296 CCDC83 0.47 6.27 0.32 1.15e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs3126085 0.935 rs10749670 chr1:152220467 G/A cg26876637 chr1:152193138 HRNR 0.46 6.57 0.34 1.89e-10 Atopic dermatitis; LUSC cis rs9503598 0.636 rs6596978 chr6:3468878 C/T cg00476032 chr6:3446245 SLC22A23 0.31 6.08 0.32 3.36e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs11828289 0.660 rs17306384 chr11:23189320 T/C cg20040320 chr11:23191996 NA -0.58 -6.1 -0.32 2.95e-9 Cancer; LUSC cis rs4604732 0.536 rs12049066 chr1:247642655 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.49 7.44 0.38 8.79e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs7746199 0.736 rs17750424 chr6:27701122 T/C cg06606381 chr12:133084897 FBRSL1 -0.94 -8.79 -0.43 8.32e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs208520 0.802 rs4710314 chr6:66883656 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -15.15 -0.64 7.76e-40 Exhaled nitric oxide output; LUSC cis rs1559088 0.895 rs7259582 chr19:33593979 A/G cg27124370 chr19:33622961 WDR88 0.56 7.43 0.38 9.38e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2289328 0.882 rs7164581 chr15:40645098 C/G cg13931752 chr15:40660718 DISP2 -0.49 -6.7 -0.34 8.8e-11 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs2652834 0.799 rs2729837 chr15:63430330 C/A cg05507819 chr15:63340323 TPM1 0.47 6.01 0.31 4.98e-9 HDL cholesterol; LUSC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg06634786 chr22:41940651 POLR3H 0.51 6.12 0.32 2.69e-9 Vitiligo; LUSC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC cis rs7809950 1.000 rs12667527 chr7:107086969 T/C cg23024343 chr7:107201750 COG5 -0.56 -8.8 -0.43 7.42e-17 Coronary artery disease; LUSC cis rs453301 0.522 rs2929309 chr8:9083771 C/A cg08975724 chr8:8085496 FLJ10661 -0.41 -5.91 -0.31 8.41e-9 Joint mobility (Beighton score); LUSC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 16.44 0.67 6.3e-45 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07918776 chr15:49170303 SHC4;EID1 0.48 7.04 0.36 1.1e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09326324 chr1:161123937 UFC1 0.43 6.39 0.33 5.61e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2860975 0.501 rs602941 chr10:96961184 G/A cg10482532 chr10:96946522 NA -0.29 -5.99 -0.31 5.28e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs7216064 0.953 rs80135947 chr17:65836001 A/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.32 -0.45 1.62e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2014572 0.967 rs8112572 chr19:57759612 T/C cg24459738 chr19:57751996 ZNF805 -0.51 -7.53 -0.38 4.65e-13 Hyperactive-impulsive symptoms; LUSC trans rs8072100 0.745 rs7214410 chr17:45422628 A/G cg03886242 chr7:26192032 NFE2L3 -0.38 -6.12 -0.32 2.6e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7072216 0.922 rs2296438 chr10:100146895 T/C cg26618903 chr10:100175079 PYROXD2 -0.29 -5.68 -0.3 2.92e-8 Metabolite levels; LUSC cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.04 -0.36 1.1e-11 Menopause (age at onset); LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg16362232 chr11:430036 ANO9 0.65 8.11 0.41 9.98e-15 Body mass index; LUSC cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg06064525 chr11:970664 AP2A2 0.5 11.02 0.52 2.71e-24 Alzheimer's disease (late onset); LUSC cis rs9309711 0.621 rs12993215 chr2:3473727 T/C cg15541040 chr2:3486749 NA -0.51 -7.65 -0.39 2.17e-13 Neurofibrillary tangles; LUSC cis rs9814567 0.752 rs4318591 chr3:134328333 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.37 -0.56 3.42e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs13315871 0.929 rs13080508 chr3:58300116 G/A cg20936604 chr3:58311152 NA -0.67 -6.67 -0.34 1.08e-10 Cholesterol, total; LUSC trans rs4729127 1.000 rs55921499 chr7:93975569 T/G cg20086523 chr13:52378287 DHRS12 0.56 5.94 0.31 7e-9 Intelligence; LUSC cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg17524180 chr13:113633600 MCF2L -0.32 -6.3 -0.33 9.56e-10 Systolic blood pressure; LUSC cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg11244672 chr19:19639970 YJEFN3 -0.61 -7.29 -0.37 2.25e-12 Bipolar disorder; LUSC cis rs9398803 0.835 rs59698523 chr6:126733094 T/C cg19875578 chr6:126661172 C6orf173 0.41 6.01 0.31 4.77e-9 Male-pattern baldness; LUSC cis rs9399401 0.626 rs12664563 chr6:142785201 A/G cg04461802 chr6:142623433 GPR126 0.46 5.9 0.31 8.97e-9 Chronic obstructive pulmonary disease; LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg12419862 chr22:24373484 LOC391322 -0.88 -15.57 -0.65 1.76e-41 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs16937 0.503 rs76939335 chr1:205178610 T/C cg21643547 chr1:205240462 TMCC2 -0.33 -5.7 -0.3 2.69e-8 Schizophrenia; LUSC cis rs7208859 0.623 rs55938328 chr17:29117010 T/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9322193 0.923 rs4870052 chr6:150161114 G/A cg00933542 chr6:150070202 PCMT1 0.33 6.78 0.35 5.31e-11 Lung cancer; LUSC cis rs4237845 0.837 rs7963992 chr12:58295949 G/C cg02175503 chr12:58329896 NA 0.61 9.99 0.48 1.01e-20 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg06494592 chr3:125709126 NA -0.53 -5.92 -0.31 8.19e-9 Blood pressure (smoking interaction); LUSC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.45 0.38 7.93e-13 Parkinson's disease; LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg18402987 chr7:1209562 NA 0.72 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9304742 0.962 rs1044467 chr19:53452769 A/G cg09915433 chr19:53449742 NA -0.63 -10.21 -0.49 1.79e-21 Psoriasis; LUSC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg06915202 chr7:98029285 BAIAP2L1 0.3 6.02 0.31 4.71e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9560113 1.000 rs9555804 chr13:112179751 T/C cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.54e-13 Menarche (age at onset); LUSC trans rs1728785 0.818 rs1170430 chr16:68604954 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.4 0.42 1.29e-15 Ulcerative colitis; LUSC cis rs9359856 0.564 rs3818133 chr6:90374456 A/G cg13799429 chr6:90582589 CASP8AP2 -0.89 -8.67 -0.43 1.94e-16 Bipolar disorder; LUSC cis rs778371 0.723 rs12993791 chr2:233690082 C/T cg08000102 chr2:233561755 GIGYF2 -0.77 -12.2 -0.56 1.46e-28 Schizophrenia; LUSC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg27170947 chr2:26402098 FAM59B -0.65 -9.42 -0.46 7.77e-19 Gut microbiome composition (summer); LUSC cis rs12472274 0.941 rs2880131 chr2:239089151 A/C cg17459225 chr2:239074497 NA 0.66 10.68 0.5 4.08e-23 Phospholipid levels (plasma); LUSC cis rs7582180 0.606 rs12618908 chr2:100947026 A/T cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs3743162 0.553 rs4842994 chr15:85415799 A/G cg12863693 chr15:85201151 NMB -0.3 -5.77 -0.3 1.81e-8 Alzheimer's disease (age of onset); LUSC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg15445000 chr17:37608096 MED1 0.4 6.82 0.35 4.25e-11 Glomerular filtration rate (creatinine); LUSC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs6845621 0.901 rs1452552 chr4:18919979 G/A cg12196642 chr4:18937545 NA -0.33 -6.41 -0.33 5.05e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.81 -0.39 7.4e-14 Height; LUSC cis rs3733418 0.929 rs13149738 chr4:165905697 T/C cg08992305 chr4:165878219 TRIM61;C4orf39 -0.51 -5.92 -0.31 8.03e-9 Obesity-related traits; LUSC trans rs7937682 0.632 rs4936834 chr11:111764017 T/A cg18187862 chr3:45730750 SACM1L -0.53 -6.42 -0.33 4.73e-10 Primary sclerosing cholangitis; LUSC cis rs10752881 1.000 rs4454510 chr1:182982303 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.67 -10.2 -0.49 1.94e-21 Colorectal cancer; LUSC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg17279839 chr7:150038598 RARRES2 0.45 6.9 0.35 2.68e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs798766 0.903 rs798726 chr4:1685211 C/T cg05874882 chr4:1763078 NA 0.51 8.21 0.41 4.74e-15 Bladder cancer;Urinary bladder cancer; LUSC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg22823121 chr1:150693482 HORMAD1 -0.52 -7.67 -0.39 1.94e-13 Urate levels; LUSC cis rs11583043 1.000 rs11583043 chr1:101466054 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.89 0.31 9.64e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg21361702 chr7:150065534 REPIN1 -0.5 -6.93 -0.35 2.21e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs295140 1.000 rs295140 chr2:201160699 T/C cg04283868 chr2:201171347 SPATS2L -0.44 -6.85 -0.35 3.62e-11 QT interval; LUSC cis rs66887589 0.967 rs3775842 chr4:120427732 G/A cg09307838 chr4:120376055 NA 0.51 7.82 0.39 7.13e-14 Diastolic blood pressure; LUSC cis rs7615952 0.546 rs2979333 chr3:125360343 T/A cg05084668 chr3:125655381 ALG1L -0.42 -5.66 -0.3 3.33e-8 Blood pressure (smoking interaction); LUSC cis rs1372520 0.577 rs1811443 chr4:90747883 G/C cg01966878 chr4:90757139 SNCA -0.41 -5.89 -0.31 9.29e-9 Neuroticism; LUSC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.83 12.42 0.56 2.32e-29 Cognitive test performance; LUSC cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs7605827 0.930 rs7593184 chr2:15598461 T/G cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.55e-18 Educational attainment (years of education); LUSC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg08270630 chr22:50330655 NA -0.42 -6.19 -0.32 1.73e-9 Schizophrenia; LUSC cis rs2354432 0.607 rs55918563 chr1:146718973 G/C cg25205988 chr1:146714368 CHD1L -1.01 -9.45 -0.46 6.1e-19 Mitochondrial DNA levels; LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg21724239 chr8:58056113 NA 0.78 9.39 0.46 1e-18 Developmental language disorder (linguistic errors); LUSC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg00339695 chr16:24857497 SLC5A11 -0.6 -9.22 -0.45 3.44e-18 Intelligence (multi-trait analysis); LUSC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg23887609 chr12:130822674 PIWIL1 0.48 7.05 0.36 1.04e-11 Menopause (age at onset); LUSC trans rs561341 1.000 rs521919 chr17:30298039 G/T cg27661571 chr11:113659931 NA -0.62 -7.43 -0.38 9.12e-13 Hip circumference adjusted for BMI; LUSC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg19418458 chr7:158789849 NA -0.64 -10.58 -0.5 9.41e-23 Facial morphology (factor 20); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07116312 chr16:89173855 ACSF3 -0.74 -6.22 -0.32 1.5e-9 Cognitive performance; LUSC cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg02782426 chr3:40428986 ENTPD3 0.39 7.46 0.38 7.6e-13 Renal cell carcinoma; LUSC cis rs5769707 0.632 rs135876 chr22:50013573 A/G cg05373962 chr22:49881684 NA -0.41 -8.6 -0.43 3.13e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.33 0.62 1.18e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg27279351 chr12:120934652 DYNLL1 0.63 8.35 0.42 1.89e-15 High light scatter reticulocyte count; LUSC cis rs950776 0.518 rs62008194 chr15:78813805 G/T cg22563815 chr15:78856949 CHRNA5 0.27 6.39 0.33 5.42e-10 Sudden cardiac arrest; LUSC cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg08470875 chr2:26401718 FAM59B 0.74 9.9 0.48 1.99e-20 Gut microbiome composition (summer); LUSC cis rs6426558 0.537 rs10799381 chr1:227239746 G/T cg10327440 chr1:227177885 CDC42BPA 0.53 7.19 0.37 4.2e-12 Neutrophil percentage of white cells; LUSC cis rs2046867 0.818 rs11929144 chr3:72868234 T/C cg25664220 chr3:72788482 NA -0.69 -12.41 -0.56 2.44e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7903847 0.642 rs7084654 chr10:99135262 G/A cg08345082 chr10:99160200 RRP12 -0.38 -7.76 -0.39 1.06e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3784262 1.000 rs9325 chr15:58245986 A/T cg12031962 chr15:58353849 ALDH1A2 0.33 6.25 0.32 1.22e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs61931739 0.500 rs7979240 chr12:34509026 C/T cg06521331 chr12:34319734 NA -0.41 -6.3 -0.33 9.2e-10 Morning vs. evening chronotype; LUSC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 15.58 0.65 1.61e-41 Platelet count; LUSC cis rs17253792 0.822 rs74824071 chr14:56095142 T/G cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18301423 chr5:131593218 PDLIM4 0.47 7.46 0.38 7.75e-13 Acylcarnitine levels; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg10862848 chr6:42927986 GNMT -0.28 -6.86 -0.35 3.36e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs17253792 0.822 rs10083499 chr14:56066590 T/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs7100689 0.784 rs10749578 chr10:82139115 A/G cg01528321 chr10:82214614 TSPAN14 -1.03 -16.38 -0.67 1.16e-44 Post bronchodilator FEV1; LUSC cis rs34779708 0.931 rs7897457 chr10:35386040 A/G cg04310649 chr10:35416472 CREM -0.41 -6.48 -0.33 3.22e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1577917 0.958 rs12215232 chr6:86785430 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.73 -0.35 7.25e-11 Response to antipsychotic treatment; LUSC cis rs912057 1.000 rs912057 chr6:6736931 C/T cg06612196 chr6:6737390 NA -0.54 -10.42 -0.5 3.45e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs7264396 0.790 rs6058288 chr20:34228680 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.6 9.08 0.44 9.71e-18 Total cholesterol levels; LUSC cis rs11122272 0.735 rs2739513 chr1:231515201 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.92 -0.48 1.67e-20 Hemoglobin concentration; LUSC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg06740227 chr12:86229804 RASSF9 -0.37 -6.0 -0.31 5.01e-9 Major depressive disorder; LUSC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg07636037 chr3:49044803 WDR6 0.44 6.38 0.33 5.9e-10 Resting heart rate; LUSC cis rs9325144 0.678 rs7315271 chr12:39164731 A/G cg26384229 chr12:38710491 ALG10B -0.6 -9.21 -0.45 3.78e-18 Morning vs. evening chronotype; LUSC cis rs11605924 0.967 rs7121611 chr11:45864142 A/T ch.11.939596F chr11:45881766 CRY2 -0.5 -7.36 -0.37 1.4e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg22535103 chr8:58192502 C8orf71 -0.73 -7.44 -0.38 8.49e-13 Developmental language disorder (linguistic errors); LUSC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg26566898 chr11:117069891 TAGLN 0.47 8.18 0.41 5.88e-15 Blood protein levels; LUSC trans rs7824557 0.564 rs12547100 chr8:11242632 G/A cg15556689 chr8:8085844 FLJ10661 -0.54 -8.21 -0.41 4.86e-15 Retinal vascular caliber; LUSC cis rs7177699 0.557 rs7165075 chr15:79115965 G/A cg15571903 chr15:79123663 NA 0.32 5.9 0.31 9.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2742417 0.603 rs2673062 chr3:45763635 A/G cg04837898 chr3:45731254 SACM1L -0.46 -7.39 -0.37 1.22e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1499972 0.941 rs6807173 chr3:117642281 T/G cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.93e-8 Schizophrenia; LUSC cis rs2580764 0.565 rs35631428 chr2:55244438 G/A cg20993754 chr2:55226987 RTN4 0.36 6.05 0.31 3.98e-9 Mean platelet volume; LUSC cis rs1577917 1.000 rs884841 chr6:86680300 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.44 -6.51 -0.34 2.81e-10 Response to antipsychotic treatment; LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.39 0.33 5.67e-10 Electroencephalogram traits; LUSC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg27535305 chr1:53392650 SCP2 -0.4 -7.62 -0.38 2.66e-13 Monocyte count; LUSC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg11764359 chr7:65958608 NA 0.79 12.72 0.57 1.76e-30 Aortic root size; LUSC cis rs56979318 1 rs56979318 chr17:80522718 A/T cg10255544 chr17:80519551 FOXK2 0.36 5.8 0.3 1.56e-8 Reticulocyte count; LUSC cis rs10782582 0.593 rs17585530 chr1:76134990 G/A cg22875332 chr1:76189707 ACADM -0.43 -6.31 -0.33 8.65e-10 Daytime sleep phenotypes; LUSC cis rs2404602 0.692 rs4383105 chr15:77055510 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.83e-12 Blood metabolite levels; LUSC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg23590916 chr17:43697445 MGC57346 0.49 6.64 0.34 1.28e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10208940 0.920 rs13400155 chr2:68723636 G/A cg12452813 chr2:68675892 NA 0.58 5.95 0.31 6.61e-9 Urate levels in lean individuals; LUSC cis rs1577917 0.917 rs1584273 chr6:86524577 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs7617773 0.817 rs13094727 chr3:48323489 G/A cg20734569 chr3:48348370 SPINK8 -0.48 -8.12 -0.41 8.91e-15 Coronary artery disease; LUSC cis rs4363385 0.747 rs946101 chr1:152972032 C/T cg00922841 chr1:152955080 SPRR1A 0.43 7.52 0.38 5.12e-13 Inflammatory skin disease; LUSC cis rs4700695 0.719 rs27078 chr5:65445331 G/C cg21114390 chr5:65439923 SFRS12 -0.64 -9.15 -0.45 5.85e-18 Facial morphology (factor 19); LUSC cis rs977987 0.815 rs11149821 chr16:75422817 C/T cg03315344 chr16:75512273 CHST6 0.48 9.1 0.45 8.27e-18 Dupuytren's disease; LUSC cis rs790123 0.933 rs812596 chr3:122382301 A/T cg17380795 chr3:122379686 NA 0.39 6.59 0.34 1.71e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs28437878 1 rs28437878 chr15:78807872 C/T cg24631222 chr15:78858424 CHRNA5 0.8 11.19 0.52 6.59e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs6121246 0.567 rs2889488 chr20:30185758 G/A cg13852791 chr20:30311386 BCL2L1 0.72 8.29 0.41 2.73e-15 Mean corpuscular hemoglobin; LUSC cis rs4595586 0.545 rs12819907 chr12:39356906 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs9527 0.590 rs726010 chr10:104841977 C/T cg05855489 chr10:104503620 C10orf26 0.53 7.96 0.4 2.78e-14 Arsenic metabolism; LUSC cis rs7119 0.717 rs12916682 chr15:77807937 A/T cg27398640 chr15:77910606 LINGO1 -0.3 -6.36 -0.33 6.74e-10 Type 2 diabetes; LUSC cis rs2180341 0.618 rs4502958 chr6:127593113 G/A cg27446573 chr6:127587934 RNF146 0.64 10.3 0.49 8.68e-22 Breast cancer; LUSC cis rs12410462 0.502 rs77615958 chr1:227806083 T/C cg23173402 chr1:227635558 NA 0.64 5.78 0.3 1.75e-8 Major depressive disorder; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg23267160 chr1:87794116 LMO4 0.41 6.39 0.33 5.47e-10 Asthma; LUSC trans rs10432489 0.708 rs12693263 chr2:181740210 A/G cg04744134 chr19:8408128 KANK3 -0.83 -6.39 -0.33 5.52e-10 QT interval; LUSC cis rs4242434 0.927 rs2291231 chr8:22463912 C/T cg03733263 chr8:22462867 KIAA1967 0.98 18.41 0.71 9.42e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.95e-8 Blood protein levels; LUSC cis rs3136441 1.000 rs2290883 chr11:46890197 A/G cg01183595 chr11:46746236 F2 -0.39 -5.94 -0.31 7.24e-9 HDL cholesterol; LUSC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg26752657 chr1:75199075 CRYZ;TYW3 0.42 6.44 0.33 4.05e-10 Resistin levels; LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg08888203 chr3:10149979 C3orf24 0.66 9.07 0.44 1.06e-17 Alzheimer's disease; LUSC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.32 -0.33 8.54e-10 Lung cancer; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg01516881 chr6:292596 DUSP22 -0.7 -11.24 -0.52 4.54e-25 Menopause (age at onset); LUSC cis rs644799 0.710 rs10831427 chr11:95508383 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 14.05 0.61 1.44e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg05253716 chr12:129299332 SLC15A4;MGC16384 -0.43 -6.53 -0.34 2.45e-10 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08467108 chr19:41304898 EGLN2 -0.42 -6.11 -0.32 2.78e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg00800038 chr16:89945340 TCF25 -0.74 -6.33 -0.33 7.93e-10 Skin colour saturation; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.05 -0.31 3.89e-9 Platelet count; LUSC cis rs6599077 0.802 rs17075542 chr3:40128458 A/G cg09455208 chr3:40491958 NA -0.34 -5.7 -0.3 2.61e-8 Sleep-related phenotypes; LUSC cis rs2404602 0.647 rs116505114 chr15:77074794 T/C cg23625390 chr15:77176239 SCAPER -0.65 -10.03 -0.48 7.07e-21 Blood metabolite levels; LUSC cis rs2281845 0.791 rs1325313 chr1:201076167 C/T cg17810781 chr1:201082982 CACNA1S 0.31 5.98 0.31 5.67e-9 Permanent tooth development; LUSC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg21724239 chr8:58056113 NA 0.78 8.41 0.42 1.19e-15 Developmental language disorder (linguistic errors); LUSC cis rs35883536 0.647 rs17411209 chr1:101046734 A/G cg06223162 chr1:101003688 GPR88 -0.47 -8.62 -0.43 2.66e-16 Monocyte count; LUSC cis rs932287 1.000 rs932287 chr11:9044767 A/G cg12365402 chr11:9010492 NRIP3 -0.35 -5.84 -0.3 1.25e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg23630131 chr7:65973040 NA 0.2 5.71 0.3 2.54e-8 Aortic root size; LUSC cis rs72781680 0.800 rs56398785 chr2:24091515 T/A cg08917208 chr2:24149416 ATAD2B 0.98 10.4 0.49 3.97e-22 Lymphocyte counts; LUSC cis rs13401104 0.531 rs12469569 chr2:237113376 T/C cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.35e-8 Educational attainment; LUSC cis rs1775715 0.835 rs12266771 chr10:32231380 G/A cg18675610 chr10:32216311 ARHGAP12 0.28 6.17 0.32 2e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1904096 0.506 rs114312933 chr4:95216802 C/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.4 -0.42 1.25e-15 Type 2 diabetes; LUSC cis rs447735 0.507 rs11645271 chr16:89729125 G/T cg04240660 chr16:89714849 CHMP1A 0.42 6.69 0.34 9.64e-11 Hemoglobin concentration; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg24813613 chr7:1882135 MAD1L1 -0.46 -7.8 -0.39 7.93e-14 Bipolar disorder and schizophrenia; LUSC cis rs73416724 1.000 rs75473868 chr6:43352623 A/G cg26312998 chr6:43337775 ZNF318 0.55 6.53 0.34 2.51e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs11700980 1.000 rs56923832 chr21:30035592 T/A cg05609335 chr17:75789393 NA 0.43 6.24 0.32 1.35e-9 QRS complex (12-leadsum); LUSC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg15445000 chr17:37608096 MED1 -0.39 -6.86 -0.35 3.28e-11 Glomerular filtration rate (creatinine); LUSC cis rs6445967 0.530 rs12486031 chr3:58409679 G/A cg13705284 chr3:58523313 ACOX2 -0.27 -5.71 -0.3 2.46e-8 Platelet count; LUSC cis rs308403 0.640 rs13128246 chr4:123721306 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.82 10.23 0.49 1.5e-21 Blood protein levels; LUSC cis rs11688816 0.904 rs360791 chr2:62917256 G/A cg17519650 chr2:63277830 OTX1 -0.42 -5.84 -0.3 1.22e-8 Body mass index; LUSC trans rs11818462 0.584 rs10884181 chr10:107334608 A/G cg03755177 chr7:44349389 CAMK2B -0.66 -5.95 -0.31 6.83e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6736093 0.966 rs11681063 chr2:112743342 G/A cg12686935 chr2:112915763 FBLN7 -0.35 -5.66 -0.3 3.34e-8 Coronary artery disease; LUSC cis rs35995292 0.500 rs6955677 chr7:38933942 C/T cg19327137 chr7:38886074 VPS41 0.55 10.26 0.49 1.15e-21 Subjective well-being (multi-trait analysis); LUSC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg04455712 chr21:45112962 RRP1B 0.49 9.36 0.46 1.18e-18 Mean corpuscular volume; LUSC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg15147215 chr3:52552868 STAB1 0.31 6.15 0.32 2.21e-9 Bipolar disorder; LUSC cis rs4363385 0.818 rs11205167 chr1:152989727 T/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.49 -0.38 6.06e-13 Inflammatory skin disease; LUSC cis rs225245 0.817 rs225284 chr17:33933006 A/C cg05299278 chr17:33885742 SLFN14 0.31 6.71 0.34 8.11e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs11039100 1.000 rs12792952 chr11:5826813 C/G cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs453301 0.624 rs7014430 chr8:8827737 T/G cg06636001 chr8:8085503 FLJ10661 0.48 7.29 0.37 2.2e-12 Joint mobility (Beighton score); LUSC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg02569458 chr12:86230093 RASSF9 0.53 8.68 0.43 1.79e-16 Major depressive disorder; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03693601 chr16:46655349 SHCBP1 0.39 6.21 0.32 1.54e-9 Asthma; LUSC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg06074448 chr4:187884817 NA -0.46 -7.68 -0.39 1.76e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1395 0.925 rs1659696 chr2:27407831 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.4 -6.62 -0.34 1.42e-10 Blood metabolite levels; LUSC cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs6723226 0.806 rs6543658 chr2:32718849 G/A cg02381751 chr2:32503542 YIPF4 0.63 9.7 0.47 9.39e-20 Intelligence (multi-trait analysis); LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg27284194 chr4:1044797 NA 0.37 6.07 0.32 3.51e-9 Longevity; LUSC cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg22117172 chr7:91764530 CYP51A1 0.32 5.73 0.3 2.25e-8 Breast cancer; LUSC cis rs17253792 0.822 rs78429067 chr14:56092551 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs11997175 0.550 rs6468206 chr8:33780878 A/C ch.8.33884649F chr8:33765107 NA 0.44 6.77 0.35 5.69e-11 Body mass index; LUSC cis rs1348850 0.526 rs2293475 chr2:178407897 C/T cg22681709 chr2:178499509 PDE11A 0.44 6.43 0.33 4.42e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01422129 chr2:677375 TMEM18 -0.45 -6.71 -0.34 8.2e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg10811474 chr19:8428787 ANGPTL4 -0.39 -5.97 -0.31 6.07e-9 HDL cholesterol; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg11494091 chr17:61959527 GH2 0.64 13.56 0.6 1.12e-33 Prudent dietary pattern; LUSC cis rs3806843 1.000 rs13184940 chr5:140172918 T/C cg19875535 chr5:140030758 IK 0.5 8.28 0.41 3.06e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs7481584 0.624 rs428726 chr11:3046201 G/A cg05729581 chr11:3078854 CARS 0.4 5.96 0.31 6.27e-9 Calcium levels; LUSC cis rs17253792 0.822 rs8007065 chr14:56081272 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg17294928 chr15:75287854 SCAMP5 -0.83 -11.27 -0.52 3.6e-25 Blood trace element (Zn levels); LUSC cis rs6840360 0.571 rs875668 chr4:152525661 C/T cg22705602 chr4:152727874 NA -0.33 -6.65 -0.34 1.23e-10 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg13560548 chr3:10150139 C3orf24 0.52 7.18 0.37 4.45e-12 Alzheimer's disease; LUSC cis rs2637266 1.000 rs755824 chr10:78381348 A/G cg18941641 chr10:78392320 NA 0.41 7.43 0.38 9.3e-13 Pulmonary function; LUSC cis rs61931739 0.635 rs1405025 chr12:33908491 C/T cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg00071950 chr4:10020882 SLC2A9 -0.47 -7.25 -0.37 2.98e-12 Bone mineral density; LUSC cis rs11048434 0.736 rs2377673 chr12:9112551 A/G cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg23583168 chr7:148888333 NA -0.88 -16.71 -0.67 5.51e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg01448562 chr3:133502909 NA -0.66 -10.6 -0.5 7.79e-23 Iron status biomarkers; LUSC cis rs6977660 1.000 rs10260360 chr7:19792824 T/C cg07541023 chr7:19748670 TWISTNB 0.57 6.39 0.33 5.59e-10 Thyroid stimulating hormone; LUSC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs9612 0.664 rs164069 chr19:44260199 T/C cg08581076 chr19:44259116 C19orf61 0.53 6.75 0.35 6.5500000000000006e-11 Exhaled nitric oxide output; LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg22920501 chr2:26401640 FAM59B -0.79 -11.86 -0.54 2.53e-27 Gut microbiome composition (summer); LUSC cis rs1055129 0.537 rs2467100 chr17:73949038 C/G cg19302996 chr17:73780495 UNK -0.48 -7.01 -0.36 1.36e-11 White matter hyperintensity burden; LUSC cis rs17270561 0.609 rs2000350 chr6:25763154 T/C cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs11122272 0.735 rs10489610 chr1:231517765 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs9815354 0.638 rs73073258 chr3:42017894 G/A cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs644799 0.710 rs12272061 chr11:95524067 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.51 0.59 1.77e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9807989 0.811 rs11689730 chr2:102969984 C/A cg03938978 chr2:103052716 IL18RAP 0.31 5.79 0.3 1.58e-8 Asthma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26386643 chr15:74753645 UBL7 0.82 6.43 0.33 4.5e-10 Cognitive performance; LUSC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs1670533 0.932 rs11731289 chr4:1057773 T/G cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC trans rs8002861 0.664 rs895266 chr13:44461179 T/C cg12856521 chr11:46389249 DGKZ 0.45 6.67 0.34 1.04e-10 Leprosy; LUSC trans rs7178375 1.000 rs10163148 chr15:31212684 C/G cg04373760 chr16:53404718 NA 0.62 8.0 0.4 2.04e-14 Hypertriglyceridemia; LUSC cis rs778371 0.676 rs7560115 chr2:233709465 T/G cg08000102 chr2:233561755 GIGYF2 -0.78 -12.19 -0.55 1.57e-28 Schizophrenia; LUSC cis rs7618501 0.722 rs9853458 chr3:49783211 A/C cg12257692 chr3:49977190 RBM6 -0.21 -5.7 -0.3 2.69e-8 Intelligence (multi-trait analysis); LUSC cis rs308403 0.509 rs13122636 chr4:123671045 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.94 16.72 0.68 5.04e-46 Blood protein levels; LUSC cis rs7937682 0.575 rs1346180 chr11:111715570 G/C cg09085632 chr11:111637200 PPP2R1B 0.96 13.57 0.6 1.08e-33 Primary sclerosing cholangitis; LUSC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg04756594 chr16:24857601 SLC5A11 0.34 5.7 0.3 2.59e-8 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg18827107 chr12:86230957 RASSF9 -0.5 -7.46 -0.38 7.71e-13 Major depressive disorder; LUSC cis rs62408225 1.000 rs2875584 chr6:90950628 C/T cg06866423 chr6:90926672 BACH2 0.4 5.71 0.3 2.47e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg07148914 chr20:33460835 GGT7 -0.52 -8.06 -0.4 1.33e-14 Glomerular filtration rate (creatinine); LUSC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg07701084 chr6:150067640 NUP43 0.53 7.92 0.4 3.48e-14 Lung cancer; LUSC cis rs9361491 0.534 rs10943568 chr6:79404207 G/T cg05283184 chr6:79620031 NA -0.39 -6.89 -0.35 2.79e-11 Intelligence (multi-trait analysis); LUSC cis rs10045504 0.502 rs17456198 chr5:38732005 A/G cg15396434 chr5:38725168 NA -0.52 -5.94 -0.31 7.04e-9 Night sleep phenotypes; LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.07 0.52 1.76e-24 Alzheimer's disease; LUSC cis rs11025559 0.812 rs10766679 chr11:20509190 T/C cg19653624 chr11:20408972 PRMT3 -0.69 -8.74 -0.43 1.17e-16 Pursuit maintenance gain; LUSC cis rs10464366 1.000 rs10464366 chr7:39121500 A/T cg18850127 chr7:39170497 POU6F2 -0.51 -7.24 -0.37 3.06e-12 IgG glycosylation; LUSC cis rs56104184 1.000 rs56104184 chr19:49370310 C/T cg15549821 chr19:49342101 PLEKHA4 -0.57 -7.73 -0.39 1.26e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg25258033 chr6:167368657 RNASET2 0.38 6.21 0.32 1.61e-9 Crohn's disease; LUSC cis rs912057 0.632 rs1294432 chr6:6745027 C/T cg06612196 chr6:6737390 NA 0.56 11.11 0.52 1.31e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg11921908 chr5:153825219 SAP30L 0.35 5.99 0.31 5.35e-9 Schizophrenia; LUSC trans rs10838798 0.504 rs7479393 chr11:48295303 G/C cg15704280 chr7:45808275 SEPT13 -0.45 -6.17 -0.32 1.94e-9 Height; LUSC cis rs2840044 1.000 rs17637907 chr17:33891386 A/G cg05299278 chr17:33885742 SLFN14 -0.3 -6.38 -0.33 6.03e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs1577917 0.771 rs10944133 chr6:86358984 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.78 -0.43 8.73e-17 Response to antipsychotic treatment; LUSC cis rs9747201 1.000 rs58472289 chr17:80111895 G/T cg17462356 chr17:80056334 FASN 0.46 6.23 0.32 1.44e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs500891 0.645 rs1180190 chr6:83966335 G/A cg08257003 chr6:84140564 ME1 0.3 6.66 0.34 1.09e-10 Platelet-derived growth factor BB levels; LUSC cis rs8017423 0.647 rs1958345 chr14:90823770 T/C cg04374321 chr14:90722782 PSMC1 -0.42 -6.39 -0.33 5.65e-10 Mortality in heart failure; LUSC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg18827107 chr12:86230957 RASSF9 0.46 6.92 0.35 2.29e-11 Major depressive disorder; LUSC cis rs3916 0.955 rs35525135 chr12:121140064 T/C cg27246729 chr12:121163418 ACADS 0.49 7.11 0.36 7.22e-12 Urinary metabolites (H-NMR features); LUSC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg05802129 chr4:122689817 NA -0.37 -6.62 -0.34 1.44e-10 Type 2 diabetes; LUSC cis rs11098499 0.818 rs10008791 chr4:120431469 A/C cg09307838 chr4:120376055 NA 0.75 10.98 0.51 3.78e-24 Corneal astigmatism; LUSC cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 11.85 0.54 2.77e-27 Colorectal cancer; LUSC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg16928487 chr17:17741425 SREBF1 0.48 9.55 0.46 2.81e-19 Total body bone mineral density; LUSC cis rs5758659 0.692 rs5751251 chr22:42640606 G/C cg00645731 chr22:42541494 CYP2D7P1 -0.31 -6.57 -0.34 1.98e-10 Cognitive function; LUSC cis rs7408868 0.831 rs11672004 chr19:15277282 T/A cg14696996 chr19:15285081 NOTCH3 0.8 7.71 0.39 1.41e-13 Pulse pressure; LUSC cis rs3741151 0.656 rs12290785 chr11:73259012 G/T cg17517138 chr11:73019481 ARHGEF17 0.92 7.8 0.39 8.22e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs55871839 0.708 rs6651298 chr8:59808307 C/G cg07426533 chr8:59803705 TOX -0.37 -6.01 -0.31 4.92e-9 Pneumonia; LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg25019033 chr10:957182 NA -0.52 -6.6 -0.34 1.59e-10 Eosinophil percentage of granulocytes; LUSC cis rs7568458 0.870 rs1010 chr2:85808982 C/T cg17127132 chr2:85788382 GGCX -0.46 -7.25 -0.37 2.86e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs8135665 0.600 rs8142379 chr22:38450971 G/A cg13116946 chr22:38479732 SLC16A8 0.42 6.24 0.32 1.32e-9 Advanced age-related macular degeneration;Age-related macular degeneration; LUSC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg26380479 chr7:97908229 NA -0.28 -6.2 -0.32 1.67e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.96 0.31 6.57e-9 Menopause (age at onset); LUSC cis rs9388451 0.531 rs9401850 chr6:126151000 T/G cg05901451 chr6:126070800 HEY2 -0.67 -10.3 -0.49 8.67e-22 Brugada syndrome; LUSC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg18876405 chr7:65276391 NA -0.55 -8.78 -0.43 8.51e-17 Aortic root size; LUSC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.06e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg02524346 chr8:600233 NA 0.82 8.3 0.41 2.62e-15 IgG glycosylation; LUSC cis rs9467711 0.606 rs16891727 chr6:26488860 C/A cg09904177 chr6:26538194 HMGN4 -0.76 -6.9 -0.35 2.61e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9326248 0.911 rs474339 chr11:117059552 G/A cg01368799 chr11:117014884 PAFAH1B2 0.51 6.68 0.34 9.94e-11 Blood protein levels; LUSC trans rs11039798 1.000 rs7125913 chr11:48984318 G/A cg15704280 chr7:45808275 SEPT13 0.77 7.43 0.38 9.41e-13 Axial length; LUSC cis rs16976116 0.901 rs1061875 chr15:55496278 C/T cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg00945038 chr17:61921165 SMARCD2 0.51 8.41 0.42 1.2e-15 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs694739 0.628 rs645078 chr11:64135298 A/C cg02228329 chr11:64053129 BAD;GPR137 0.41 5.78 0.3 1.69e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg18538332 chr22:24372958 LOC391322 -0.42 -7.74 -0.39 1.22e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg06808227 chr14:105710500 BRF1 -0.66 -9.9 -0.48 1.9e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 8.11 0.41 9.88e-15 Schizophrenia; LUSC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.4 0.64 8.58e-41 Intelligence (multi-trait analysis); LUSC cis rs9361491 0.508 rs10943567 chr6:79402451 A/G cg05283184 chr6:79620031 NA -0.39 -7.12 -0.36 6.7e-12 Intelligence (multi-trait analysis); LUSC cis rs7762018 0.607 rs3800544 chr6:170058374 C/T cg19338460 chr6:170058176 WDR27 -0.88 -7.29 -0.37 2.22e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs3741151 0.881 rs73542929 chr11:73094539 G/T cg17517138 chr11:73019481 ARHGEF17 1.04 8.76 0.43 1.02e-16 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -8.21 -0.41 4.72e-15 Blood pressure (smoking interaction); LUSC cis rs4964805 0.632 rs9706225 chr12:104188086 T/C cg02344784 chr12:104178138 NT5DC3 0.46 8.86 0.44 4.73e-17 Attention deficit hyperactivity disorder; LUSC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.54 -7.37 -0.37 1.33e-12 Mean platelet volume; LUSC cis rs10203711 1.000 rs4663328 chr2:239574103 A/G cg14580085 chr2:239553406 NA -0.41 -7.0 -0.36 1.41e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs950776 0.593 rs680244 chr15:78871288 T/C cg06917634 chr15:78832804 PSMA4 -0.72 -12.45 -0.56 1.76e-29 Sudden cardiac arrest; LUSC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.46 7.74 0.39 1.21e-13 Vitiligo; LUSC cis rs4144743 1.000 rs11871251 chr17:45331427 G/A cg18085866 chr17:45331354 ITGB3 -0.77 -8.01 -0.4 1.91e-14 Body mass index; LUSC cis rs7267979 1.000 rs4815412 chr20:25350325 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.45 0.75 7.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg22166914 chr1:53195759 ZYG11B 0.67 11.34 0.53 1.92e-25 Monocyte count; LUSC cis rs2346177 0.605 rs7556828 chr2:46663172 A/G cg02822958 chr2:46747628 ATP6V1E2 -0.4 -7.07 -0.36 9.31e-12 HDL cholesterol; LUSC cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg04586622 chr2:25135609 ADCY3 0.4 8.3 0.41 2.59e-15 Body mass index in non-asthmatics; LUSC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg05754148 chr16:3507555 NAT15 -0.65 -7.83 -0.39 6.64e-14 Tuberculosis; LUSC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg22875332 chr1:76189707 ACADM 0.86 15.03 0.64 2.29e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Melanoma; LUSC cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg03146154 chr1:46216737 IPP 0.51 7.51 0.38 5.39e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7241530 0.662 rs6506734 chr18:75888374 A/G cg14642773 chr18:75888474 NA 0.36 5.92 0.31 8.19e-9 Educational attainment (years of education); LUSC cis rs911555 0.576 rs8015723 chr14:103895909 A/G cg12935359 chr14:103987150 CKB 0.56 8.76 0.43 1e-16 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg08888203 chr3:10149979 C3orf24 0.65 8.79 0.43 8.22e-17 Alzheimer's disease; LUSC cis rs4746822 0.539 rs10998646 chr10:70976702 G/T cg14418922 chr10:70824840 NA -0.42 -7.28 -0.37 2.35e-12 Glycemic traits (pregnancy); LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg26314531 chr2:26401878 FAM59B 0.67 9.64 0.47 1.42e-19 Gut microbiome composition (summer); LUSC cis rs12220238 1.000 rs11000912 chr10:75948477 A/C cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.77 0.35 5.76e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs12908161 1.000 rs12908161 chr15:85207825 A/G cg12863693 chr15:85201151 NMB 0.43 8.71 0.43 1.45e-16 Schizophrenia; LUSC cis rs8141797 0.748 rs5760186 chr22:24435954 G/A cg00411358 chr22:24577142 SUSD2 0.62 6.08 0.32 3.31e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 7.83 0.39 6.33e-14 Schizophrenia; LUSC cis rs7760535 0.763 rs9487666 chr6:111869024 A/C cg22127309 chr6:111907043 TRAF3IP2 -0.39 -7.39 -0.38 1.15e-12 Metabolic traits; LUSC cis rs2070488 0.804 rs13092539 chr3:38458725 G/A cg24069376 chr3:38537580 EXOG 0.38 7.22 0.37 3.52e-12 Electrocardiographic conduction measures; LUSC cis rs7617480 0.648 rs4974083 chr3:49000626 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.63 9.1 0.45 8.37e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg20476274 chr7:133979776 SLC35B4 0.87 16.91 0.68 8.63e-47 Mean platelet volume; LUSC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg07395648 chr5:131743802 NA -0.45 -7.16 -0.36 5.21e-12 Breast cancer;Mosquito bite size; LUSC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg03806693 chr22:41940476 POLR3H 1.0 14.25 0.62 2.41e-36 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg03146154 chr1:46216737 IPP -0.52 -7.39 -0.37 1.21e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2070488 0.745 rs7649153 chr3:38467753 T/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.65 10.09 0.48 4.62e-21 Electrocardiographic conduction measures; LUSC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs10493773 1.000 rs10493773 chr1:86125753 C/T cg17807903 chr1:86174739 ZNHIT6 0.43 9.12 0.45 7.06e-18 Urate levels in overweight individuals; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01066274 chr16:75019182 WDR59 -0.42 -6.19 -0.32 1.76e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg10621924 chr7:39171070 POU6F2 0.5 7.81 0.39 7.37e-14 IgG glycosylation; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.03 0.44 1.4e-17 Prudent dietary pattern; LUSC cis rs11122272 0.735 rs2808596 chr1:231530723 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.15 -0.49 2.75e-21 Hemoglobin concentration; LUSC trans rs3808502 0.549 rs4841564 chr8:11425809 T/G cg06636001 chr8:8085503 FLJ10661 -0.6 -8.73 -0.43 1.2e-16 Neuroticism; LUSC cis rs55871839 0.684 rs13271523 chr8:59806664 T/C cg07426533 chr8:59803705 TOX -0.37 -6.05 -0.31 3.86e-9 Pneumonia; LUSC cis rs870825 0.616 rs10006828 chr4:185651416 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.36 0.56 3.65e-29 Blood protein levels; LUSC cis rs244293 0.760 rs4794547 chr17:53011172 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.42 -6.26 -0.32 1.19e-9 Menarche (age at onset); LUSC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg12292205 chr6:26970375 C6orf41 -0.55 -6.73 -0.35 7.22e-11 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.863 rs10004484 chr4:120442428 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.55 0.34 2.13e-10 Corneal astigmatism; LUSC cis rs7267979 0.966 rs2500417 chr20:25383287 A/G cg08601574 chr20:25228251 PYGB -0.45 -6.89 -0.35 2.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11677416 1.000 rs4848303 chr2:113552698 A/G cg27083787 chr2:113543245 IL1A 0.47 7.33 0.37 1.79e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs6674970 1.000 rs6676190 chr1:151079317 C/T cg03258749 chr1:151040405 MLLT11 -0.43 -6.59 -0.34 1.76e-10 Childhood ear infection; LUSC trans rs7786808 0.707 rs10247026 chr7:158230595 C/T cg02030672 chr11:45687055 CHST1 0.47 7.0 0.36 1.45e-11 Obesity-related traits; LUSC cis rs12776158 0.901 rs12413873 chr10:71212091 C/G cg12610070 chr10:71211762 TSPAN15 -0.49 -7.22 -0.37 3.52e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6700896 0.931 rs11208715 chr1:66154414 G/T cg04111102 chr1:66153794 NA 0.33 7.24 0.37 3.17e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg07936489 chr17:37558343 FBXL20 -0.69 -9.54 -0.46 3.22e-19 Glomerular filtration rate (creatinine); LUSC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg10729496 chr3:10149963 C3orf24 0.54 7.18 0.37 4.44e-12 Alzheimer's disease; LUSC cis rs12753569 0.967 rs6696116 chr1:76483732 C/T cg00791851 chr1:76518896 NA -0.33 -6.33 -0.33 7.94e-10 Personality dimensions; LUSC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg09877947 chr5:131593287 PDLIM4 0.48 7.87 0.4 4.99e-14 Breast cancer; LUSC cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.6 0.69 1.6e-49 Chronic sinus infection; LUSC cis rs72960926 0.744 rs72950579 chr6:74915560 G/A cg03266952 chr6:74778945 NA -0.79 -6.42 -0.33 4.65e-10 Metabolite levels (MHPG); LUSC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 6.67 0.34 1.06e-10 Platelet count; LUSC cis rs2692947 0.631 rs2312954 chr2:96772447 C/T cg22654517 chr2:96458247 NA -0.32 -5.98 -0.31 5.85e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9341808 0.718 rs6910201 chr6:80904938 G/C cg08355045 chr6:80787529 NA 0.59 10.22 0.49 1.64e-21 Sitting height ratio; LUSC cis rs72781680 1.000 rs72788278 chr2:24095285 A/C cg08917208 chr2:24149416 ATAD2B 0.87 10.02 0.48 7.9e-21 Lymphocyte counts; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg03188948 chr7:1209495 NA 0.41 6.06 0.31 3.69e-9 Longevity;Endometriosis; LUSC cis rs4077468 1.000 rs11801695 chr1:205916175 A/C cg07157834 chr1:205819609 PM20D1 0.42 5.99 0.31 5.49e-9 Cystic fibrosis-related diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14121103 chr3:43731973 ABHD5 0.41 6.15 0.32 2.24e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -6.06 -0.31 3.66e-9 Developmental language disorder (linguistic errors); LUSC cis rs63406760 1 rs63406760 chr12:123742692 TG/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.24 -0.32 1.35e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1728785 1.000 rs7118 chr16:68600855 G/T cg02972257 chr16:68554789 NA -0.53 -6.68 -0.34 1e-10 Ulcerative colitis; LUSC cis rs709400 0.593 rs12898029 chr14:103877884 T/C cg10523860 chr14:103875565 MARK3 0.39 6.12 0.32 2.56e-9 Body mass index; LUSC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.91 0.35 2.49e-11 Parkinson's disease; LUSC cis rs8141797 0.901 rs5751804 chr22:24490105 A/C cg00411358 chr22:24577142 SUSD2 0.61 6.32 0.33 8.56e-10 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs12908161 0.959 rs11637728 chr15:85203392 A/T cg11189052 chr15:85197271 WDR73 0.48 5.91 0.31 8.56e-9 Schizophrenia; LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg22166914 chr1:53195759 ZYG11B 0.6 9.8 0.47 4.26e-20 Monocyte count; LUSC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg08508325 chr11:3079039 CARS -0.51 -12.55 -0.57 7.33e-30 Longevity; LUSC cis rs4499344 0.730 rs35098593 chr19:33103939 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs9677476 0.863 rs12465438 chr2:232073106 G/A cg07929768 chr2:232055508 NA 0.37 7.11 0.36 7.15e-12 Food antigen IgG levels; LUSC cis rs13191362 0.573 rs1877769 chr6:163252315 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.57 8.09 0.4 1.09e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8112211 0.911 rs2270095 chr19:38840896 A/G cg14299480 chr19:38876666 GGN -0.35 -6.19 -0.32 1.74e-9 Blood protein levels; LUSC cis rs6463523 0.933 rs79984239 chr7:766220 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.99 20.6 0.75 1.97e-61 Subjective well-being; LUSC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.26 0.37 2.67e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg17366294 chr4:99064904 C4orf37 0.61 10.89 0.51 7.87e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs912057 1.000 rs1294407 chr6:6738103 C/G cg06612196 chr6:6737390 NA 0.56 10.74 0.51 2.55e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg26395211 chr5:140044315 WDR55 0.45 6.99 0.36 1.5e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.33 -0.49 6.9e-22 Platelet count; LUSC cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg13010199 chr12:38710504 ALG10B 0.66 10.16 0.49 2.52e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs1015291 0.680 rs1352903 chr12:19994758 A/G cg01501474 chr7:55323552 NA -0.45 -5.97 -0.31 6.09e-9 Diastolic blood pressure; LUSC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs2737618 0.674 rs2260033 chr1:200086074 G/A cg21825944 chr1:200113062 NR5A2 -0.3 -5.76 -0.3 1.95e-8 Uric acid levels; LUSC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg05425664 chr17:57184151 TRIM37 -0.56 -8.3 -0.41 2.6e-15 Intelligence (multi-trait analysis); LUSC cis rs12681287 0.570 rs4961188 chr8:87383033 T/C cg00550725 chr8:87521180 FAM82B -0.43 -5.71 -0.3 2.51e-8 Caudate activity during reward; LUSC cis rs6494488 0.500 rs72741320 chr15:64721745 C/A cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Coronary artery disease; LUSC cis rs6445967 0.569 rs7622497 chr3:58282673 A/C cg23715586 chr3:58305044 RPP14 0.45 7.62 0.39 2.57e-13 Platelet count; LUSC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg20607287 chr7:12443886 VWDE -0.56 -6.55 -0.34 2.15e-10 Coronary artery disease; LUSC cis rs4842666 0.915 rs117742247 chr12:89991313 C/T cg00757033 chr12:89920650 WDR51B 0.51 6.68 0.34 9.94e-11 Blood pressure; LUSC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg24324837 chr19:49891574 CCDC155 0.5 6.41 0.33 5.07e-10 Multiple sclerosis; LUSC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.47 -7.16 -0.36 5.16e-12 Colorectal cancer; LUSC cis rs5997397 0.720 rs132549 chr22:29318724 C/T cg02153584 chr22:29168773 CCDC117 -0.44 -7.01 -0.36 1.32e-11 Red cell distribution width; LUSC cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg05347473 chr6:146136440 FBXO30 0.46 7.96 0.4 2.72e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1003719 0.667 rs2835606 chr21:38490851 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.59 9.07 0.44 1.05e-17 Eye color traits; LUSC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg05802129 chr4:122689817 NA -0.37 -6.72 -0.34 8e-11 Type 2 diabetes; LUSC cis rs4947962 0.618 rs12538489 chr7:55099836 C/T cg23757825 chr7:55092271 EGFR -0.66 -8.69 -0.43 1.69e-16 Subjective response to lithium treatment; LUSC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7809950 1.000 rs67982599 chr7:107100104 T/G cg23024343 chr7:107201750 COG5 -0.54 -8.71 -0.43 1.42e-16 Coronary artery disease; LUSC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg06238570 chr21:40685208 BRWD1 0.48 7.27 0.37 2.5e-12 Cognitive function; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg17811310 chr19:34012326 PEPD 0.34 5.96 0.31 6.55e-9 Metabolite levels (Pyroglutamine); LUSC cis rs939658 0.805 rs11634903 chr15:79436192 C/T cg17916960 chr15:79447300 NA 0.53 10.75 0.51 2.33e-23 Refractive error; LUSC cis rs8177253 0.696 rs4459901 chr3:133465699 T/C cg16414030 chr3:133502952 NA -0.4 -5.93 -0.31 7.45e-9 Iron status biomarkers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19877921 chr17:61904685 PSMC5;FTSJ3 -0.38 -6.13 -0.32 2.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2420915 0.642 rs7071645 chr10:122863589 T/C cg06217504 chr4:147056211 NA 0.45 6.17 0.32 1.96e-9 Fibrinogen levels; LUSC cis rs9467773 0.967 rs1535276 chr6:26520941 T/C cg09904177 chr6:26538194 HMGN4 0.75 14.21 0.61 3.52e-36 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg00684032 chr4:1343700 KIAA1530 -0.37 -6.34 -0.33 7.44e-10 Obesity-related traits; LUSC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg23630131 chr7:65973040 NA -0.21 -5.8 -0.3 1.55e-8 Aortic root size; LUSC cis rs735539 0.609 rs7332034 chr13:21214943 T/C cg04906043 chr13:21280425 IL17D -0.44 -6.73 -0.35 7.42e-11 Dental caries; LUSC cis rs1018836 0.812 rs10808619 chr8:91622916 A/T cg16814680 chr8:91681699 NA -0.78 -13.23 -0.59 1.96e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg05340658 chr4:99064831 C4orf37 0.65 10.99 0.52 3.31e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 0.967 rs7214892 chr17:57065401 G/A cg12560992 chr17:57184187 TRIM37 0.89 16.27 0.67 2.93e-44 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.545 rs11611625 chr12:39387207 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg16797656 chr11:68205561 LRP5 0.35 5.9 0.31 8.96e-9 Total body bone mineral density; LUSC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.63 -0.34 1.32e-10 Aortic root size; LUSC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg05025164 chr4:1340916 KIAA1530 0.42 6.3 0.33 9.36e-10 Obesity-related traits; LUSC cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg11266682 chr4:10021025 SLC2A9 0.43 7.67 0.39 1.91e-13 Bone mineral density; LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg03352830 chr11:487213 PTDSS2 0.7 8.83 0.44 5.97e-17 Body mass index; LUSC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg27398817 chr8:82754497 SNX16 -0.66 -8.41 -0.42 1.2e-15 Diastolic blood pressure; LUSC cis rs3845702 0.736 rs72962575 chr2:180862133 C/G cg01881094 chr2:180872142 CWC22 1.03 12.16 0.55 2.04e-28 Schizophrenia; LUSC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg06634786 chr22:41940651 POLR3H 0.52 5.89 0.31 9.62e-9 Vitiligo; LUSC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.64 7.96 0.4 2.65e-14 Lung function (FEV1/FVC); LUSC cis rs9326248 0.581 rs10892072 chr11:116960313 G/A cg20608306 chr11:116969690 SIK3 0.37 6.97 0.36 1.66e-11 Blood protein levels; LUSC cis rs4363385 0.782 rs310126 chr1:153019416 A/C cg00922841 chr1:152955080 SPRR1A -0.42 -7.3 -0.37 2.11e-12 Inflammatory skin disease; LUSC cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg12573674 chr2:1569213 NA -0.49 -5.74 -0.3 2.16e-8 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.731 rs10015579 chr4:120271802 T/C cg24375607 chr4:120327624 NA 0.67 10.54 0.5 1.33e-22 Corneal astigmatism; LUSC cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg24558204 chr6:135376177 HBS1L 0.67 10.4 0.49 4.01e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg03188948 chr7:1209495 NA 0.62 7.04 0.36 1.07e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg03676636 chr4:99064102 C4orf37 0.3 6.51 0.34 2.82e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg02475777 chr4:1388615 CRIPAK 0.39 5.97 0.31 6.06e-9 Obesity-related traits; LUSC cis rs2191566 0.960 rs56171514 chr19:44506110 G/C cg03039196 chr19:44506973 ZNF230 0.34 5.64 0.3 3.54e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.43 -0.33 4.34e-10 Lung cancer; LUSC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 1.88e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs5769765 0.955 rs1321 chr22:50297435 A/G cg26441486 chr22:50317300 CRELD2 0.51 7.7 0.39 1.52e-13 Schizophrenia; LUSC cis rs72792276 1.000 rs78529289 chr5:127405378 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.92 7.75 0.39 1.11e-13 Red cell distribution width; LUSC cis rs79976124 0.837 rs12201218 chr6:66653619 C/T cg07460842 chr6:66804631 NA -0.7 -8.73 -0.43 1.21e-16 Type 2 diabetes; LUSC cis rs9649465 0.561 rs2429618 chr7:123421662 G/A cg03229431 chr7:123269106 ASB15 0.48 7.69 0.39 1.66e-13 Migraine; LUSC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg00677455 chr12:58241039 CTDSP2 0.72 11.47 0.53 6.72e-26 Multiple sclerosis; LUSC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg21862992 chr11:68658383 NA 0.5 7.79 0.39 8.77e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg03161606 chr19:29218774 NA 0.61 9.38 0.46 1.01e-18 Methadone dose in opioid dependence; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24658452 chr6:133134754 RPS12 -0.42 -6.09 -0.32 3.09e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.66 11.28 0.53 3.19e-25 Personality dimensions; LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23791442 chr22:43010704 POLDIP3;RNU12 0.55 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis); LUSC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg22431228 chr1:16359049 CLCNKA -0.51 -10.18 -0.49 2.27e-21 Dilated cardiomyopathy; LUSC cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg19508488 chr2:152266495 RIF1 0.56 7.9 0.4 3.96e-14 Lung cancer; LUSC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg03433033 chr1:76189801 ACADM 0.67 8.49 0.42 7.08e-16 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg19046167 chr17:80928561 B3GNTL1 0.48 7.23 0.37 3.31e-12 Breast cancer; LUSC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg00599273 chr12:58146742 CDK4 0.3 5.73 0.3 2.25e-8 Multiple sclerosis; LUSC trans rs7939886 0.841 rs10501349 chr11:56021284 G/A cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg24060327 chr5:131705240 SLC22A5 -0.68 -11.76 -0.54 6.2e-27 Breast cancer; LUSC cis rs6940638 0.688 rs7764984 chr6:27034181 A/G cg12292205 chr6:26970375 C6orf41 -0.39 -5.83 -0.3 1.29e-8 Intelligence (multi-trait analysis); LUSC cis rs3768617 0.811 rs12066082 chr1:183054863 G/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.69 0.43 1.65e-16 Fuchs's corneal dystrophy; LUSC cis rs1005224 0.853 rs2360035 chr14:76297093 A/T cg25116370 chr14:76127843 TTLL5;C14orf1 0.39 5.89 0.31 9.35e-9 Large artery stroke; LUSC cis rs9527 0.615 rs9733635 chr10:104711940 G/A cg05855489 chr10:104503620 C10orf26 0.52 8.09 0.4 1.13e-14 Arsenic metabolism; LUSC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.98 -0.36 1.57e-11 Lung cancer; LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.39e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg12658694 chr1:38397304 INPP5B 0.58 10.03 0.48 7.48e-21 Coronary artery disease; LUSC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg05368731 chr17:41323189 NBR1 0.93 16.05 0.66 2.27e-43 Menopause (age at onset); LUSC cis rs595982 0.559 rs17206700 chr19:49361255 A/G cg15549821 chr19:49342101 PLEKHA4 -0.59 -8.05 -0.4 1.45e-14 Red cell distribution width; LUSC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg04398451 chr17:18023971 MYO15A -0.49 -7.95 -0.4 2.97e-14 Total body bone mineral density; LUSC trans rs1728785 1.000 rs1728784 chr16:68591156 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.46 0.42 8.65e-16 Ulcerative colitis; LUSC cis rs7568458 0.777 rs12473819 chr2:85773061 A/G cg17127132 chr2:85788382 GGCX 0.45 7.11 0.36 7.29e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg15534755 chr11:117069859 TAGLN 0.35 6.15 0.32 2.25e-9 Blood protein levels; LUSC cis rs3803170 0.513 rs10849946 chr12:111830485 C/G cg10833066 chr12:111807467 FAM109A -0.39 -7.38 -0.37 1.29e-12 Mean corpuscular hemoglobin; LUSC cis rs7241530 0.610 rs7243831 chr18:75906420 T/C cg14642773 chr18:75888474 NA 0.39 5.96 0.31 6.32e-9 Educational attainment (years of education); LUSC cis rs6121246 0.954 rs7266148 chr20:30431070 G/T cg18721089 chr20:30220636 NA -0.37 -6.3 -0.33 9.5e-10 Mean corpuscular hemoglobin; LUSC trans rs1941687 0.702 rs9956636 chr18:31304974 C/T cg27147174 chr7:100797783 AP1S1 -0.43 -6.33 -0.33 7.82e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs4356932 0.875 rs6826408 chr4:76973564 A/C cg00809888 chr4:76862425 NAAA 0.35 5.82 0.3 1.37e-8 Blood protein levels; LUSC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.55 0.34 2.22e-10 Schizophrenia; LUSC cis rs4423214 0.879 rs1792277 chr11:71138918 C/T cg05163923 chr11:71159392 DHCR7 -0.66 -8.52 -0.42 5.58e-16 Vitamin D levels; LUSC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg13683864 chr3:40499215 RPL14 -0.93 -15.21 -0.64 4.75e-40 Renal cell carcinoma; LUSC cis rs3008870 0.583 rs11208978 chr1:67442210 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.94 -13.7 -0.6 3.26e-34 Lymphocyte percentage of white cells; LUSC cis rs739401 1.000 rs739401 chr11:3036324 C/T cg25174290 chr11:3078921 CARS -0.41 -6.1 -0.32 2.97e-9 Longevity; LUSC cis rs981844 0.714 rs6822142 chr4:154683524 C/T cg14289246 chr4:154710475 SFRP2 -0.52 -7.43 -0.38 9.38e-13 Response to statins (LDL cholesterol change); LUSC cis rs662064 0.962 rs620405 chr1:10554794 T/C cg20482658 chr1:10539492 PEX14 -0.32 -6.6 -0.34 1.62e-10 Asthma; LUSC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -17.47 -0.69 5.27e-49 Coronary artery disease; LUSC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg18512352 chr11:47633146 NA -0.44 -9.04 -0.44 1.34e-17 Subjective well-being; LUSC cis rs1801251 1.000 rs2675971 chr2:233726154 A/G cg08000102 chr2:233561755 GIGYF2 -0.68 -11.13 -0.52 1.12e-24 Coronary artery disease; LUSC cis rs7917772 0.560 rs4919664 chr10:104363408 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 11.03 0.52 2.51e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1153858 0.668 rs63603561 chr15:45593323 T/A cg26924012 chr15:45694286 SPATA5L1 -1.08 -17.25 -0.69 4.04e-48 Homoarginine levels; LUSC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg08280861 chr8:58055591 NA 0.56 6.05 0.31 3.96e-9 Developmental language disorder (linguistic errors); LUSC cis rs7746199 0.736 rs10484399 chr6:27534528 A/G cg26958806 chr6:27640298 NA 0.74 6.68 0.34 1.02e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9311676 0.632 rs7610312 chr3:58374029 A/G cg26110898 chr3:58419937 PDHB 0.42 6.75 0.35 6.62e-11 Systemic lupus erythematosus; LUSC trans rs800082 0.516 rs2889043 chr3:144231238 C/T cg24215973 chr2:240111563 HDAC4 0.45 6.85 0.35 3.66e-11 Smoking behavior; LUSC cis rs612683 0.694 rs6688364 chr1:101000874 G/A cg06223162 chr1:101003688 GPR88 0.52 9.57 0.46 2.52e-19 Breast cancer; LUSC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg21963583 chr11:68658836 MRPL21 0.58 9.17 0.45 4.86e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg27535305 chr1:53392650 SCP2 -0.4 -7.49 -0.38 6.15e-13 Monocyte count; LUSC cis rs6961069 0.708 rs2030710 chr7:80220026 A/C cg04458919 chr7:80252533 CD36 -0.41 -7.23 -0.37 3.36e-12 Platelet count; LUSC cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg22875332 chr1:76189707 ACADM -0.41 -6.09 -0.32 3.07e-9 Daytime sleep phenotypes; LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg19318889 chr4:1322082 MAEA 0.8 14.13 0.61 7.35e-36 Longevity; LUSC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg21856205 chr7:94953877 PON1 -0.35 -5.74 -0.3 2.09e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg03709012 chr19:19516395 GATAD2A 0.87 14.92 0.63 6.45e-39 Tonsillectomy; LUSC cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg24692254 chr21:30365293 RNF160 0.79 14.38 0.62 7.99e-37 Dental caries; LUSC cis rs9902453 0.933 rs8074028 chr17:28461687 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.87 0.4 4.86e-14 Coffee consumption (cups per day); LUSC trans rs6951245 1.000 rs77346188 chr7:1114023 C/A cg13565492 chr6:43139072 SRF -0.63 -6.63 -0.34 1.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg08085267 chr17:45401833 C17orf57 0.54 8.82 0.43 6.58e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg09904177 chr6:26538194 HMGN4 -0.75 -6.61 -0.34 1.51e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs738322 0.967 rs132971 chr22:38561911 T/G cg17652424 chr22:38574118 PLA2G6 -0.31 -6.73 -0.35 7.49e-11 Cutaneous nevi; LUSC cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg18225595 chr11:63971243 STIP1 0.52 6.05 0.31 3.95e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6543140 0.890 rs61122764 chr2:102999520 A/G cg09003973 chr2:102972529 NA 0.56 7.29 0.37 2.2e-12 Blood protein levels; LUSC cis rs6693567 0.586 rs875514 chr1:150484555 C/G cg15654264 chr1:150340011 RPRD2 0.45 7.26 0.37 2.72e-12 Migraine; LUSC cis rs11864453 0.826 rs2240243 chr16:72137561 A/G cg01557791 chr16:72042693 DHODH 0.49 6.94 0.36 2.02e-11 Fibrinogen levels; LUSC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg09365446 chr1:150670422 GOLPH3L 0.55 8.46 0.42 8.21e-16 Tonsillectomy; LUSC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg16423285 chr20:60520624 NA 0.88 11.76 0.54 5.8e-27 Obesity-related traits; LUSC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg07424592 chr7:64974309 NA 0.59 5.93 0.31 7.53e-9 Diabetic kidney disease; LUSC cis rs2742234 0.541 rs61845684 chr10:43744983 T/C cg15436174 chr10:43711423 RASGEF1A 0.43 6.72 0.34 8.04e-11 Hirschsprung disease; LUSC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg08847533 chr14:75593920 NEK9 -0.75 -13.14 -0.58 4.47e-32 Height; LUSC cis rs2050392 0.517 rs302423 chr10:30772513 A/G cg25182066 chr10:30743637 MAP3K8 -0.45 -6.52 -0.34 2.59e-10 Inflammatory bowel disease; LUSC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg23630131 chr7:65973040 NA 0.21 5.79 0.3 1.6e-8 Aortic root size; LUSC cis rs9549260 0.755 rs12585277 chr13:41224813 C/T cg21288729 chr13:41239152 FOXO1 0.65 10.04 0.48 6.48e-21 Red blood cell count; LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg04944784 chr2:26401820 FAM59B 0.79 11.29 0.53 2.95e-25 Gut microbiome composition (summer); LUSC cis rs17818399 0.708 rs13000706 chr2:46838247 C/G cg02822958 chr2:46747628 ATP6V1E2 0.34 5.93 0.31 7.58e-9 Height; LUSC cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg01579765 chr21:45077557 HSF2BP -0.47 -9.78 -0.47 5.04e-20 Mean corpuscular volume; LUSC cis rs56804039 1.000 rs11780966 chr8:8383396 T/G cg15556689 chr8:8085844 FLJ10661 -0.58 -7.33 -0.37 1.8e-12 Cervical cancer; LUSC cis rs7267979 0.966 rs2151144 chr20:25414924 G/C cg08601574 chr20:25228251 PYGB -0.43 -6.68 -0.34 9.75e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11700980 0.551 rs2832023 chr21:30112996 A/G cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs7954584 0.635 rs3847694 chr12:122325820 A/G cg10207240 chr12:122356781 WDR66 0.44 6.5 0.33 3.01e-10 Mean corpuscular volume; LUSC trans rs9784649 1.000 rs56004901 chr5:24998968 A/G cg08600765 chr20:34638493 LOC647979 -0.53 -6.35 -0.33 6.94e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg17892150 chr10:133769511 PPP2R2D -0.66 -9.31 -0.45 1.82e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg08975724 chr8:8085496 FLJ10661 0.47 6.88 0.35 2.88e-11 Mood instability; LUSC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg22638593 chr5:131593259 PDLIM4 0.38 5.79 0.3 1.62e-8 Breast cancer; LUSC cis rs1577917 0.959 rs12201739 chr6:86720739 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.77 -0.43 9.54e-17 Response to antipsychotic treatment; LUSC cis rs2245368 0.523 rs67814714 chr7:76517422 T/C cg15770687 chr7:76625569 PMS2L11 0.85 8.85 0.44 5.3e-17 Body mass index in physically inactive individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg12292205 chr6:26970375 C6orf41 -0.7 -12.22 -0.56 1.23e-28 Autism spectrum disorder or schizophrenia; LUSC cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg12615879 chr12:58013172 SLC26A10 -0.27 -5.72 -0.3 2.31e-8 Multiple sclerosis; LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg16647868 chr5:131706066 SLC22A5 0.38 6.03 0.31 4.42e-9 Breast cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10586042 chr5:36152206 SKP2;LMBRD2 -0.39 -5.98 -0.31 5.85e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg11247378 chr22:39784982 NA -0.64 -12.82 -0.57 6.95e-31 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.510 rs2068678 chr1:152906956 G/A cg25856811 chr1:152973957 SPRR3 -0.38 -6.05 -0.31 3.98e-9 Inflammatory skin disease; LUSC cis rs1005224 0.864 rs11625011 chr14:76144828 G/A cg04684003 chr14:76127793 TTLL5;C14orf1 -0.63 -8.57 -0.42 3.91e-16 Large artery stroke; LUSC cis rs10911232 0.507 rs4575047 chr1:182976028 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.55 0.5 1.21e-22 Hypertriglyceridemia; LUSC cis rs7267979 1.000 rs7018 chr20:25278261 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.03 0.74 3.52e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg20503657 chr10:835505 NA 1.05 13.48 0.59 2.19e-33 Eosinophil percentage of granulocytes; LUSC cis rs9649213 0.559 rs56997921 chr7:98009224 G/A cg08684580 chr7:98029266 BAIAP2L1 0.38 5.81 0.3 1.46e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs11676348 0.783 rs4674252 chr2:218984478 G/A cg00012203 chr2:219082015 ARPC2 -0.56 -8.97 -0.44 2.11e-17 Ulcerative colitis; LUSC cis rs6951245 0.572 rs60918895 chr7:1039036 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -6.5 -0.34 2.94e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg05985134 chr18:33552581 C18orf21 0.51 6.83 0.35 4.01e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.52 -8.02 -0.4 1.8e-14 Menarche (age at onset); LUSC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.66e-13 Intelligence (multi-trait analysis); LUSC cis rs4474465 0.850 rs10899552 chr11:78262262 G/A cg27205649 chr11:78285834 NARS2 0.5 5.96 0.31 6.56e-9 Alzheimer's disease (survival time); LUSC cis rs7000551 0.751 rs2469775 chr8:22373238 T/C cg12081754 chr8:22256438 SLC39A14 0.42 6.37 0.33 6.35e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.52 7.99 0.4 2.28e-14 Schizophrenia; LUSC cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg15997130 chr1:24165203 NA -0.52 -8.65 -0.43 2.24e-16 Immature fraction of reticulocytes; LUSC cis rs7590368 0.961 rs12474895 chr2:10957848 A/C cg15705551 chr2:10952987 PDIA6 0.58 7.95 0.4 2.95e-14 Educational attainment (years of education); LUSC cis rs6456156 0.846 rs204293 chr6:167514481 T/C cg07741184 chr6:167504864 NA 0.33 5.81 0.3 1.42e-8 Primary biliary cholangitis; LUSC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6582630 0.599 rs7967598 chr12:38540760 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.29 -0.33 9.77e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2425143 0.908 rs12480111 chr20:34423186 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -5.96 -0.31 6.26e-9 Blood protein levels; LUSC cis rs12458462 0.787 rs56006341 chr18:77439844 G/T cg11879182 chr18:77439856 CTDP1 0.72 11.91 0.55 1.68e-27 Monocyte count; LUSC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC trans rs561341 1.000 rs68140514 chr17:30335781 T/C cg20587970 chr11:113659929 NA -1.18 -16.31 -0.67 2.13e-44 Hip circumference adjusted for BMI; LUSC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg07936489 chr17:37558343 FBXL20 0.69 9.66 0.47 1.27e-19 Glomerular filtration rate (creatinine); LUSC trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg13615516 chr5:77269221 NA 0.39 6.66 0.34 1.16e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg09365446 chr1:150670422 GOLPH3L 0.47 7.07 0.36 9.18e-12 Melanoma; LUSC cis rs17253792 0.822 rs10137340 chr14:56050989 A/G cg01858014 chr14:56050164 KTN1 -0.79 -7.71 -0.39 1.5e-13 Putamen volume; LUSC cis rs6121246 0.567 rs6088796 chr20:30213229 C/T cg13852791 chr20:30311386 BCL2L1 0.77 8.73 0.43 1.25e-16 Mean corpuscular hemoglobin; LUSC trans rs6502050 0.835 rs4789668 chr17:80161990 C/T cg07393940 chr7:158741817 NA 0.37 6.61 0.34 1.5e-10 Life satisfaction; LUSC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg14583973 chr4:3374767 RGS12 0.4 8.57 0.42 3.96e-16 Serum sulfate level; LUSC trans rs429017 0.541 rs400896 chr5:41273955 A/T cg17064250 chr6:45388500 RUNX2 0.32 6.15 0.32 2.23e-9 Blood protein levels; LUSC trans rs2562456 0.833 rs4429400 chr19:21520965 T/C cg00806126 chr19:22604979 ZNF98 -0.43 -6.0 -0.31 5.12e-9 Pain; LUSC cis rs2652834 0.718 rs2729831 chr15:63396039 A/T cg05507819 chr15:63340323 TPM1 0.55 7.11 0.36 7.22e-12 HDL cholesterol; LUSC cis rs9311676 0.618 rs12152337 chr3:58365271 T/C cg13750441 chr3:58318267 PXK 0.35 6.76 0.35 6.33e-11 Systemic lupus erythematosus; LUSC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.66 -0.3 3.31e-8 Life satisfaction; LUSC cis rs11190604 1.000 rs3750633 chr10:102308214 C/T cg07080220 chr10:102295463 HIF1AN 0.65 8.51 0.42 6.11e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9467773 0.572 rs62394558 chr6:26604650 G/A cg09904177 chr6:26538194 HMGN4 0.65 11.1 0.52 1.4e-24 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg19468946 chr17:37922297 IKZF3 -0.43 -6.89 -0.35 2.86e-11 Self-reported allergy; LUSC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Tonsillectomy; LUSC cis rs2798269 1.000 rs2761916 chr13:22148286 A/C cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.95 -0.31 6.92e-9 PR segment; LUSC cis rs8077889 0.871 rs8081101 chr17:41904332 C/T cg26893861 chr17:41843967 DUSP3 0.86 13.17 0.58 3.36e-32 Triglycerides; LUSC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg07636037 chr3:49044803 WDR6 1.06 17.85 0.7 1.59e-50 Parkinson's disease; LUSC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.71e-13 Bipolar disorder; LUSC cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg22467129 chr15:76604101 ETFA -0.43 -6.72 -0.35 7.94e-11 Blood metabolite levels; LUSC cis rs2204008 0.548 rs8189475 chr12:38037115 C/T cg13010199 chr12:38710504 ALG10B 0.63 9.87 0.48 2.49e-20 Bladder cancer; LUSC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.51 -0.46 3.81e-19 Gut microbiome composition (summer); LUSC cis rs244731 1.000 rs244730 chr5:176539212 A/G cg16006841 chr5:176797999 RGS14 -0.59 -8.54 -0.42 4.8e-16 Urate levels in lean individuals; LUSC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs3806843 0.966 rs2563262 chr5:140137712 C/G cg26395211 chr5:140044315 WDR55 0.38 5.77 0.3 1.77e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9395066 0.545 rs2396372 chr6:44966867 T/C cg25276700 chr6:44698697 NA 0.29 5.81 0.3 1.48e-8 Height; LUSC trans rs7824557 0.836 rs2736378 chr8:11119760 G/A cg08975724 chr8:8085496 FLJ10661 -0.48 -7.34 -0.37 1.65e-12 Retinal vascular caliber; LUSC cis rs6693567 0.507 rs828784 chr1:150335240 T/A cg15654264 chr1:150340011 RPRD2 0.46 7.35 0.37 1.5e-12 Migraine; LUSC cis rs765787 0.530 rs4775832 chr15:45534828 A/G cg25801113 chr15:45476975 SHF 0.35 7.17 0.37 4.84e-12 Uric acid levels; LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.84 0.65 1.57e-42 Platelet count; LUSC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg06505273 chr16:24850292 NA -0.41 -5.74 -0.3 2.16e-8 Intelligence (multi-trait analysis); LUSC cis rs12950390 0.893 rs12325760 chr17:45840886 C/T cg03474202 chr17:45855739 NA -0.28 -6.27 -0.32 1.12e-9 IgG glycosylation; LUSC cis rs9304742 0.683 rs10402714 chr19:53463680 G/A cg09503522 chr19:53445286 ZNF321 -0.35 -5.67 -0.3 3.06e-8 Psoriasis; LUSC trans rs7715474 0.629 rs6863440 chr5:120084621 G/C cg12284098 chr8:1993893 MYOM2 0.33 6.1 0.32 2.92e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9300255 0.664 rs12316131 chr12:123817796 T/C cg00376283 chr12:123451042 ABCB9 -0.66 -7.74 -0.39 1.18e-13 Neutrophil percentage of white cells; LUSC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg06219351 chr7:158114137 PTPRN2 0.5 9.02 0.44 1.46e-17 Calcium levels; LUSC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg04362960 chr10:104952993 NT5C2 -0.6 -9.31 -0.45 1.74e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg06784218 chr1:46089804 CCDC17 -0.57 -11.33 -0.53 2.11e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg10553204 chr2:20871195 GDF7 -0.34 -5.9 -0.31 8.83e-9 Abdominal aortic aneurysm; LUSC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg26384229 chr12:38710491 ALG10B 0.92 17.78 0.7 2.98e-50 Heart rate; LUSC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg04455712 chr21:45112962 RRP1B 0.45 8.53 0.42 5.06e-16 Mean corpuscular volume; LUSC cis rs7267979 0.932 rs6138588 chr20:25487523 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.96 0.7 5.99e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7980687 0.657 rs2851447 chr12:123665113 G/C cg13010344 chr12:123464640 ARL6IP4 -0.48 -7.19 -0.37 4.15e-12 Height;Educational attainment;Head circumference (infant); LUSC cis rs17255340 0.559 rs1143796 chr6:84005867 T/C cg08257003 chr6:84140564 ME1 0.31 7.78 0.39 9.43e-14 Platelet-derived growth factor BB levels; LUSC cis rs739401 0.869 rs395188 chr11:3072631 A/G cg05729581 chr11:3078854 CARS 0.5 7.48 0.38 6.66e-13 Longevity; LUSC cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg22496339 chr2:162101262 NA -0.45 -6.5 -0.34 2.95e-10 Intelligence (multi-trait analysis); LUSC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg09796270 chr17:17721594 SREBF1 0.46 7.97 0.4 2.53e-14 Total body bone mineral density; LUSC cis rs9389248 0.690 rs2064101 chr6:135250530 G/A cg24558204 chr6:135376177 HBS1L -0.6 -8.73 -0.43 1.23e-16 High light scatter reticulocyte percentage of red cells; LUSC trans rs61931739 0.500 rs11053166 chr12:34385898 A/C cg13010199 chr12:38710504 ALG10B -0.64 -9.99 -0.48 9.53e-21 Morning vs. evening chronotype; LUSC cis rs868036 0.681 rs4776977 chr15:68108219 C/T cg24579218 chr15:68104479 NA -0.39 -6.81 -0.35 4.68e-11 Restless legs syndrome; LUSC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC trans rs61931739 0.533 rs7970871 chr12:33917301 G/A cg26384229 chr12:38710491 ALG10B 0.51 7.63 0.39 2.51e-13 Morning vs. evening chronotype; LUSC cis rs11997175 0.625 rs7460540 chr8:33597907 A/G ch.8.33884649F chr8:33765107 NA 0.42 6.66 0.34 1.15e-10 Body mass index; LUSC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg24324837 chr19:49891574 CCDC155 0.49 6.25 0.32 1.23e-9 Multiple sclerosis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06527153 chr1:109289113 STXBP3 0.42 6.29 0.33 1.02e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg00343986 chr7:65444356 GUSB 0.43 6.4 0.33 5.34e-10 Aortic root size; LUSC trans rs1814175 0.817 rs3974439 chr11:50022607 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.32 0.77 3.6e-68 Prudent dietary pattern; LUSC cis rs7296418 0.738 rs1568428 chr12:123738876 A/G cg05973401 chr12:123451056 ABCB9 -0.52 -7.71 -0.39 1.5e-13 Platelet count; LUSC cis rs7267979 1.000 rs6076336 chr20:25319212 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.56 -0.75 2.79e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2274273 0.624 rs66551709 chr14:55791022 A/T cg04306507 chr14:55594613 LGALS3 0.48 9.69 0.47 9.94e-20 Protein biomarker; LUSC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg11062466 chr8:58055876 NA 0.49 6.45 0.33 3.88e-10 Developmental language disorder (linguistic errors); LUSC cis rs9788721 0.836 rs72738718 chr15:78735438 G/C cg18825076 chr15:78729989 IREB2 -0.59 -9.76 -0.47 5.72e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06850241 chr22:41845214 NA -0.31 -5.85 -0.3 1.18e-8 Vitiligo; LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg11764359 chr7:65958608 NA -0.7 -10.79 -0.51 1.7e-23 Aortic root size; LUSC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg22963979 chr7:1858916 MAD1L1 0.55 8.54 0.42 4.83e-16 Bipolar disorder and schizophrenia; LUSC cis rs9300255 0.568 rs1790102 chr12:123704890 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs911555 0.755 rs2756122 chr14:103983033 C/G cg12935359 chr14:103987150 CKB -0.46 -7.46 -0.38 7.56e-13 Intelligence (multi-trait analysis); LUSC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg16797656 chr11:68205561 LRP5 0.36 6.08 0.32 3.22e-9 Total body bone mineral density; LUSC cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg13010199 chr12:38710504 ALG10B 0.65 10.07 0.48 5.45e-21 Bladder cancer; LUSC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg01416388 chr22:39784598 NA -0.44 -7.44 -0.38 8.8e-13 Intelligence (multi-trait analysis); LUSC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg00343986 chr7:65444356 GUSB -0.48 -7.2 -0.37 3.98e-12 Aortic root size; LUSC cis rs2562456 0.917 rs2650793 chr19:21676115 C/G cg00806126 chr19:22604979 ZNF98 0.37 5.87 0.31 1.05e-8 Pain; LUSC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg19346786 chr7:2764209 NA -0.49 -8.1 -0.41 1.04e-14 Height; LUSC cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg08645402 chr16:4508243 NA 0.47 7.34 0.37 1.66e-12 Schizophrenia; LUSC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg05425664 chr17:57184151 TRIM37 -0.56 -8.22 -0.41 4.62e-15 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg23630131 chr7:65973040 NA -0.2 -5.67 -0.3 3.05e-8 Aortic root size; LUSC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg03678062 chr6:149772716 ZC3H12D -0.33 -6.9 -0.35 2.62e-11 Dupuytren's disease; LUSC cis rs2742234 0.541 rs10899786 chr10:43744583 G/A cg07801480 chr10:43725741 RASGEF1A -0.39 -5.68 -0.3 2.93e-8 Hirschsprung disease; LUSC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4730250 0.707 rs257387 chr7:106808480 G/A cg02696742 chr7:106810147 HBP1 -0.66 -9.21 -0.45 3.62e-18 Osteoarthritis; LUSC cis rs4969178 0.930 rs2292644 chr17:76394449 C/T cg05887092 chr17:76393375 PGS1 0.52 9.5 0.46 4.27e-19 HDL cholesterol levels; LUSC cis rs4988958 0.565 rs12712146 chr2:103008714 C/T cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.65e-12 Asthma (childhood onset); LUSC cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg11244672 chr19:19639970 YJEFN3 0.59 7.05 0.36 1.06e-11 Bipolar disorder; LUSC cis rs9916302 0.706 rs4332770 chr17:37704712 T/C cg07936489 chr17:37558343 FBXL20 -0.83 -10.29 -0.49 9.28e-22 Glomerular filtration rate (creatinine); LUSC cis rs2708377 0.656 rs116607079 chr12:11262044 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.81 7.88 0.4 4.71e-14 Bitter taste perception; LUSC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg20891283 chr12:69753455 YEATS4 0.8 14.43 0.62 4.94e-37 Blood protein levels; LUSC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg15556689 chr8:8085844 FLJ10661 -0.53 -8.18 -0.41 6.18e-15 Neuroticism; LUSC cis rs11935103 0.569 rs10022988 chr4:187291021 T/C cg24610901 chr4:187293114 NA -0.42 -5.84 -0.3 1.21e-8 Response to citalopram treatment; LUSC trans rs7829975 0.606 rs11776838 chr8:8794801 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.43 -0.33 4.39e-10 Mood instability; LUSC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg20476274 chr7:133979776 SLC35B4 0.8 13.71 0.6 2.91e-34 Mean platelet volume; LUSC cis rs1534166 0.647 rs9876158 chr3:133508300 T/C cg08048268 chr3:133502702 NA 0.35 6.34 0.33 7.31e-10 Alcohol consumption (transferrin glycosylation); LUSC cis rs317689 0.819 rs317677 chr12:69691806 G/A cg11871910 chr12:69753446 YEATS4 0.47 6.32 0.33 8.44e-10 Response to diuretic therapy; LUSC cis rs4654899 0.802 rs7519685 chr1:21192623 G/A cg01072550 chr1:21505969 NA -0.48 -7.23 -0.37 3.26e-12 Superior frontal gyrus grey matter volume; LUSC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg14440974 chr22:39074834 NA -0.37 -6.14 -0.32 2.34e-9 Menopause (age at onset); LUSC cis rs734999 0.588 rs10910098 chr1:2533250 C/A cg18932078 chr1:2524107 MMEL1 0.32 7.2 0.37 4e-12 Ulcerative colitis; LUSC cis rs612683 0.517 rs3767832 chr1:100943100 A/G cg06223162 chr1:101003688 GPR88 -0.48 -9.42 -0.46 7.63e-19 Breast cancer; LUSC trans rs61931739 0.534 rs10844728 chr12:34020109 G/C cg26384229 chr12:38710491 ALG10B 0.73 11.43 0.53 9.6e-26 Morning vs. evening chronotype; LUSC cis rs4363385 0.818 rs370162 chr1:153005488 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC trans rs11782517 0.924 rs58868895 chr8:10109343 T/G cg15556689 chr8:8085844 FLJ10661 0.48 6.07 0.32 3.54e-9 Nose size; LUSC trans rs208520 0.526 rs6913344 chr6:66754285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.16 -23.24 -0.79 9.33e-72 Exhaled nitric oxide output; LUSC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg07936489 chr17:37558343 FBXL20 0.87 12.1 0.55 3.54e-28 Glomerular filtration rate (creatinine); LUSC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.38 -0.46 1.05e-18 Prostate cancer; LUSC trans rs1486139 0.905 rs9639004 chr7:46282865 G/A cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -7.87 -0.4 5.01e-14 Hemoglobin concentration; LUSC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.23e-8 Total body bone mineral density; LUSC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg16850897 chr7:100343110 ZAN -0.45 -5.75 -0.3 2.01e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9807989 0.765 rs13424006 chr2:102967236 T/C cg09003973 chr2:102972529 NA 0.45 6.19 0.32 1.8e-9 Asthma; LUSC cis rs7954584 0.505 rs11043278 chr12:122412145 C/T cg22618164 chr12:122356400 WDR66 0.6 8.76 0.43 9.63e-17 Mean corpuscular volume; LUSC cis rs2637266 1.000 rs10219021 chr10:78364516 C/T cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.62e-12 Pulmonary function; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 2.92e-13 Prudent dietary pattern; LUSC cis rs10465746 0.935 rs11580836 chr1:84333310 C/T cg10977910 chr1:84465055 TTLL7 0.45 6.38 0.33 5.91e-10 Obesity-related traits; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg08027265 chr7:2291960 NA -0.37 -5.9 -0.31 8.83e-9 Bipolar disorder and schizophrenia; LUSC cis rs9747201 1.000 rs36048409 chr17:80096961 T/A cg17462356 chr17:80056334 FASN 0.46 6.21 0.32 1.56e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11890956 chr21:40555474 PSMG1 -0.87 -15.39 -0.64 8.72e-41 Cognitive function; LUSC cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg23158103 chr7:148848205 ZNF398 0.47 7.7 0.39 1.55e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs62229266 0.804 rs2835259 chr21:37425302 T/C cg12218747 chr21:37451666 NA -0.38 -5.67 -0.3 3.08e-8 Mitral valve prolapse; LUSC cis rs10992471 0.756 rs10123342 chr9:95087824 T/G cg14631576 chr9:95140430 CENPP -0.32 -5.66 -0.3 3.23e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg13319975 chr6:146136371 FBXO30 -0.66 -9.86 -0.47 2.74e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg07636037 chr3:49044803 WDR6 0.43 6.26 0.32 1.21e-9 Resting heart rate; LUSC cis rs17095355 0.901 rs17126938 chr10:111761351 T/C cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.16 -0.36 5.31e-12 Biliary atresia; LUSC cis rs11690935 0.688 rs7600835 chr2:172521827 C/T cg13550731 chr2:172543902 DYNC1I2 -0.74 -11.6 -0.54 2.18e-26 Schizophrenia; LUSC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg08680598 chr22:49984980 NA -0.34 -6.37 -0.33 6.22e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6469656 1.000 rs10105610 chr8:117654088 C/G cg24004040 chr8:117650383 NA -0.41 -6.03 -0.31 4.39e-9 Colorectal cancer; LUSC cis rs8072100 0.713 rs11651643 chr17:45483229 A/G cg08085267 chr17:45401833 C17orf57 -0.5 -7.25 -0.37 2.97e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3540 0.618 rs11636089 chr15:91039527 C/T cg22089800 chr15:90895588 ZNF774 0.65 9.79 0.47 4.74e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg22029157 chr1:209979665 IRF6 0.74 11.02 0.52 2.73e-24 Cleft lip with or without cleft palate; LUSC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg06221963 chr1:154839813 KCNN3 -0.65 -15.56 -0.65 1.89e-41 Prostate cancer; LUSC cis rs73198271 0.740 rs67766414 chr8:8649533 C/T cg01851573 chr8:8652454 MFHAS1 0.53 8.52 0.42 5.36e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs854765 0.693 rs12936037 chr17:17777245 A/G cg09796270 chr17:17721594 SREBF1 -0.45 -7.8 -0.39 7.78e-14 Total body bone mineral density; LUSC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg05347473 chr6:146136440 FBXO30 -0.56 -9.64 -0.47 1.42e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs4594175 0.707 rs4901096 chr14:51722826 G/C cg23942311 chr14:51606299 NA 0.29 5.72 0.3 2.34e-8 Cancer; LUSC trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg07741184 chr6:167504864 NA 0.34 6.18 0.32 1.86e-9 Crohn's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01956158 chr8:132916947 EFR3A 0.42 6.28 0.32 1.08e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg25258033 chr6:167368657 RNASET2 0.39 6.28 0.32 1.07e-9 Crohn's disease; LUSC cis rs11048434 0.736 rs34798934 chr12:9108444 C/T cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC trans rs7980799 0.682 rs1601005 chr12:33634658 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.53 -0.42 5.13e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21582582 chr3:182698605 DCUN1D1 -0.47 -8.36 -0.42 1.72e-15 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.58 -0.38 3.48e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11031096 0.502 rs4910875 chr11:4047855 C/G cg18678763 chr11:4115507 RRM1 -0.48 -6.37 -0.33 6.37e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg16362232 chr11:430036 ANO9 0.67 8.36 0.42 1.67e-15 Body mass index; LUSC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg23583168 chr7:148888333 NA -0.82 -14.94 -0.63 5.27e-39 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs934734 0.563 rs11673956 chr2:65597657 A/G cg08085232 chr2:65598271 SPRED2 -0.45 -6.9 -0.35 2.62e-11 Rheumatoid arthritis; LUSC cis rs6940638 0.688 rs7744759 chr6:27119826 G/A cg05738196 chr6:26577821 NA -0.48 -6.79 -0.35 5.24e-11 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.967 rs11117116 chr12:86331087 A/T cg02569458 chr12:86230093 RASSF9 0.42 6.81 0.35 4.67e-11 Major depressive disorder; LUSC cis rs10492096 0.945 rs2041386 chr12:6562538 C/T cg13857086 chr12:6580257 VAMP1 0.82 9.17 0.45 4.96e-18 Hip geometry; LUSC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg10172584 chr19:19639581 YJEFN3 -0.5 -5.91 -0.31 8.47e-9 Bipolar disorder; LUSC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg11764359 chr7:65958608 NA -0.69 -10.5 -0.5 1.75e-22 Aortic root size; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02475777 chr4:1388615 CRIPAK -0.57 -8.96 -0.44 2.41e-17 Longevity; LUSC cis rs6456156 0.586 rs1407315 chr6:167468659 A/G cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg00684032 chr4:1343700 KIAA1530 0.37 6.49 0.33 3.18e-10 Obesity-related traits; LUSC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg18350739 chr11:68623251 NA -0.38 -6.47 -0.33 3.43e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06634786 chr22:41940651 POLR3H -0.5 -6.19 -0.32 1.8e-9 Vitiligo; LUSC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.46 -0.38 7.78e-13 Aortic root size; LUSC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg22535103 chr8:58192502 C8orf71 -0.56 -6.71 -0.34 8.29e-11 Developmental language disorder (linguistic errors); LUSC cis rs1595825 0.891 rs73054819 chr2:198625744 G/T cg00982548 chr2:198649783 BOLL -0.59 -7.35 -0.37 1.51e-12 Ulcerative colitis; LUSC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.56 -0.69 2.31e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs9581857 0.685 rs9319367 chr13:28042197 T/C cg22138327 chr13:27999177 GTF3A 0.74 8.02 0.4 1.84e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg05368731 chr17:41323189 NBR1 -0.94 -15.88 -0.66 1.06e-42 Menopause (age at onset); LUSC cis rs769267 0.631 rs7252981 chr19:19692579 T/C cg03709012 chr19:19516395 GATAD2A -0.49 -7.12 -0.36 6.85e-12 Tonsillectomy; LUSC cis rs35096708 1.000 rs35096708 chr16:89887249 G/A cg26513180 chr16:89883248 FANCA -0.53 -6.25 -0.32 1.28e-9 Skin aging (microtopography measurement); LUSC cis rs2742234 0.590 rs2505506 chr10:43645854 C/T cg15436174 chr10:43711423 RASGEF1A -0.41 -7.04 -0.36 1.07e-11 Hirschsprung disease; LUSC cis rs782590 0.559 rs12617719 chr2:55915826 G/C cg03859395 chr2:55845619 SMEK2 -0.75 -11.87 -0.54 2.45e-27 Metabolic syndrome; LUSC cis rs10791323 0.598 rs10750550 chr11:133736083 A/G cg00579200 chr11:133705235 NA -0.41 -6.16 -0.32 2.12e-9 Childhood ear infection; LUSC cis rs561341 0.663 rs72821936 chr17:30224068 C/G cg13647721 chr17:30228624 UTP6 0.69 9.22 0.45 3.44e-18 Hip circumference adjusted for BMI; LUSC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg19230755 chr7:65878503 NA -0.4 -5.79 -0.3 1.64e-8 Aortic root size; LUSC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg21017887 chr14:105400489 NA 0.68 13.09 0.58 7.04e-32 Rheumatoid arthritis; LUSC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg18404041 chr3:52824283 ITIH1 -0.51 -9.61 -0.47 1.79e-19 Bipolar disorder; LUSC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg19920283 chr7:105172520 RINT1 0.58 6.11 0.32 2.71e-9 Bipolar disorder (body mass index interaction); LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg08859206 chr1:53392774 SCP2 -0.55 -9.41 -0.46 8.02e-19 Monocyte count; LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.2 0.52 6.31e-25 Prudent dietary pattern; LUSC cis rs7843479 0.511 rs4379446 chr8:21777595 C/G cg17168535 chr8:21777572 XPO7 0.84 15.44 0.65 5.65e-41 Mean corpuscular volume; LUSC cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg26597838 chr10:835615 NA -0.48 -6.53 -0.34 2.45e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg04944784 chr2:26401820 FAM59B 0.65 9.3 0.45 1.85e-18 Gut microbiome composition (summer); LUSC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg12963246 chr6:28129442 ZNF389 0.5 6.8 0.35 4.94e-11 Depression; LUSC cis rs7640424 0.721 rs326356 chr3:107824563 C/T cg09227934 chr3:107805635 CD47 -0.37 -6.0 -0.31 5.28e-9 Body mass index; LUSC cis rs9788682 0.947 rs12439240 chr15:78829091 T/C cg24631222 chr15:78858424 CHRNA5 0.84 11.36 0.53 1.71e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7481584 0.581 rs105686 chr11:3062467 G/A cg25174290 chr11:3078921 CARS -0.41 -6.15 -0.32 2.27e-9 Calcium levels; LUSC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg06850241 chr22:41845214 NA -0.3 -5.88 -0.31 9.71e-9 Vitiligo; LUSC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg08736216 chr1:53307985 ZYG11A 0.29 6.06 0.31 3.68e-9 Monocyte count; LUSC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg26597838 chr10:835615 NA 1.22 16.83 0.68 1.8e-46 Eosinophil percentage of granulocytes; LUSC cis rs7131987 0.903 rs11050162 chr12:29420054 T/G cg09582351 chr12:29534625 ERGIC2 -0.32 -6.66 -0.34 1.12e-10 QT interval; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09826306 chr16:89990300 TUBB3 0.68 5.97 0.31 5.9e-9 Cognitive performance; LUSC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg13939156 chr17:80058883 NA -0.33 -6.41 -0.33 4.96e-10 Life satisfaction; LUSC cis rs7113850 0.541 rs7131336 chr11:24219418 C/T ch.11.24196551F chr11:24239977 NA 0.96 9.08 0.44 9.71e-18 Bone fracture in osteoporosis; LUSC cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg06784218 chr1:46089804 CCDC17 0.48 9.35 0.46 1.3e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs427941 0.703 rs201435 chr7:101732865 G/C cg06246474 chr7:101738831 CUX1 0.42 6.82 0.35 4.28e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19717773 chr7:2847554 GNA12 -0.39 -6.14 -0.32 2.38e-9 Height; LUSC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg00074818 chr8:8560427 CLDN23 0.6 9.79 0.47 4.46e-20 Obesity-related traits; LUSC trans rs7829975 0.659 rs4382480 chr8:8721473 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.42 0.33 4.58e-10 Mood instability; LUSC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg10560079 chr2:191398806 TMEM194B 0.46 7.56 0.38 3.98e-13 Pulse pressure; LUSC cis rs5009270 0.512 rs75795332 chr7:112241690 G/A cg27282281 chr7:112262583 NA 0.43 5.75 0.3 1.98e-8 Osteoarthritis (hip); LUSC cis rs503341 0.756 rs11231591 chr11:63587986 G/T cg04850017 chr11:63683019 RCOR2 0.29 5.78 0.3 1.67e-8 Pulse pressure; LUSC cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg15556689 chr8:8085844 FLJ10661 -0.62 -9.8 -0.47 4.35e-20 Systolic blood pressure; LUSC cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.47 -6.21 -0.32 1.59e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg13628971 chr7:2884303 GNA12 -0.46 -6.29 -0.33 9.85e-10 Height; LUSC trans rs11098499 0.863 rs1010740 chr4:120463409 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.49 -6.82 -0.35 4.33e-11 Corneal astigmatism; LUSC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.91 -0.4 3.82e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs7674212 0.539 rs6850461 chr4:104120041 C/T cg16532752 chr4:104119610 CENPE -0.47 -6.8 -0.35 4.81e-11 Type 2 diabetes; LUSC cis rs4730250 0.707 rs61014091 chr7:106810107 A/C cg02696742 chr7:106810147 HBP1 -0.65 -9.36 -0.46 1.18e-18 Osteoarthritis; LUSC cis rs801193 0.613 rs2016325 chr7:66323500 T/C cg00343986 chr7:65444356 GUSB -0.39 -5.88 -0.31 1.02e-8 Aortic root size; LUSC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg09455208 chr3:40491958 NA 0.6 10.6 0.5 7.95e-23 Renal cell carcinoma; LUSC cis rs3733585 0.682 rs13124563 chr4:9927553 A/G cg00071950 chr4:10020882 SLC2A9 0.54 9.08 0.44 9.94e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs637571 0.584 rs7107912 chr11:65603252 G/A cg26695010 chr11:65641043 EFEMP2 0.59 8.83 0.43 6.1e-17 Eosinophil percentage of white cells; LUSC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg13628971 chr7:2884303 GNA12 0.5 6.82 0.35 4.23e-11 Height; LUSC cis rs8078723 0.714 rs3785550 chr17:38149727 C/T cg17467752 chr17:38218738 THRA -0.7 -11.27 -0.52 3.54e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.48 0.38 6.59e-13 Motion sickness; LUSC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg02117656 chr17:79614917 TSPAN10 -0.3 -5.67 -0.3 3.16e-8 Eye color traits; LUSC cis rs6500395 1.000 rs871903 chr16:48593643 A/C cg04672837 chr16:48644449 N4BP1 0.43 6.34 0.33 7.56e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs117623576 0.887 rs211411 chr10:32394992 T/C cg03047570 chr10:32398778 NA 0.71 7.9 0.4 4.12e-14 Anti-saccade response; LUSC cis rs7923609 0.934 rs10822153 chr10:65056813 C/A cg01631684 chr10:65280961 REEP3 -0.42 -6.42 -0.33 4.76e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.55 -0.38 4.17e-13 Aortic root size; LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18099408 chr3:52552593 STAB1 -0.41 -6.96 -0.36 1.84e-11 Bipolar disorder; LUSC cis rs7100689 0.646 rs1572819 chr10:82112488 A/G cg01528321 chr10:82214614 TSPAN14 0.84 12.47 0.56 1.42e-29 Post bronchodilator FEV1; LUSC cis rs12681288 0.712 rs2600488 chr8:1021266 A/C cg04851639 chr8:1020857 NA -0.39 -8.4 -0.42 1.33e-15 Schizophrenia; LUSC cis rs10197940 0.638 rs2288193 chr2:152348842 T/A cg19508488 chr2:152266495 RIF1 0.54 7.63 0.39 2.47e-13 Lung cancer; LUSC cis rs7267979 1.000 rs910997 chr20:25267301 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.54 0.75 3.49e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs66887589 0.777 rs4643791 chr4:120265619 A/G cg24375607 chr4:120327624 NA -0.5 -7.93 -0.4 3.28e-14 Diastolic blood pressure; LUSC cis rs1953600 0.729 rs2819872 chr10:81906269 A/G cg00277334 chr10:82204260 NA 0.46 7.45 0.38 8.09e-13 Sarcoidosis; LUSC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg11843238 chr5:131593191 PDLIM4 0.37 6.45 0.33 3.91e-10 Breast cancer; LUSC cis rs11690935 0.959 rs12692973 chr2:172642057 A/G cg13550731 chr2:172543902 DYNC1I2 0.88 14.51 0.62 2.49e-37 Schizophrenia; LUSC cis rs10193935 0.901 rs6544549 chr2:42693056 C/T cg27598129 chr2:42591480 NA 0.62 7.78 0.39 9.16e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11122272 0.705 rs2486742 chr1:231507254 G/A cg06096015 chr1:231504339 EGLN1 0.56 9.95 0.48 1.33e-20 Hemoglobin concentration; LUSC cis rs4595586 0.545 rs12819907 chr12:39356906 A/G cg26384229 chr12:38710491 ALG10B 0.5 7.23 0.37 3.24e-12 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.28 0.45 2.23e-18 Prudent dietary pattern; LUSC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg16049864 chr8:95962084 TP53INP1 -0.43 -7.22 -0.37 3.61e-12 Type 2 diabetes; LUSC trans rs75804782 0.641 rs72983853 chr2:239324210 C/T cg01134436 chr17:81009848 B3GNTL1 0.65 6.42 0.33 4.55e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg23985595 chr17:80112537 CCDC57 0.31 5.95 0.31 6.87e-9 Life satisfaction; LUSC trans rs9929218 1.000 rs28549017 chr16:68758828 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -12.45 -0.56 1.76e-29 Colorectal cancer; LUSC cis rs9467711 0.539 rs34436535 chr6:26370365 G/C cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18075040 chr12:96337100 AMDHD1;CCDC38 -0.41 -6.2 -0.32 1.67e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg10360323 chr17:41437877 NA 0.4 5.71 0.3 2.44e-8 Menopause (age at onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg09720372 chr3:108308234 KIAA1524;DZIP3 -0.49 -6.63 -0.34 1.34e-10 Hepatitis; LUSC cis rs7264396 0.623 rs2590984 chr20:34597031 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.06 -0.36 9.7e-12 Total cholesterol levels; LUSC cis rs2573652 0.722 rs8041337 chr15:100541808 T/C cg00587665 chr15:100533223 ADAMTS17 -0.39 -7.06 -0.36 9.69e-12 Height; LUSC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg24110177 chr3:50126178 RBM5 -0.54 -8.8 -0.43 7.39e-17 Intelligence (multi-trait analysis); LUSC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.69 0.47 1.02e-19 Personality dimensions; LUSC cis rs34375054 0.624 rs7132026 chr12:125678096 A/G cg25124228 chr12:125621409 AACS 0.41 5.81 0.3 1.43e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg08048268 chr3:133502702 NA -0.49 -9.75 -0.47 6.27e-20 Iron status biomarkers; LUSC trans rs9860340 0.652 rs17024791 chr3:87637975 C/G cg03644585 chr7:884825 UNC84A 0.42 6.03 0.31 4.35e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7296418 0.663 rs4553407 chr12:123750748 G/C cg00376283 chr12:123451042 ABCB9 0.72 11.05 0.52 2.03e-24 Platelet count; LUSC cis rs113835537 0.529 rs11227514 chr11:66286627 G/A cg24851651 chr11:66362959 CCS 0.53 7.92 0.4 3.52e-14 Airway imaging phenotypes; LUSC cis rs11864453 0.611 rs9926927 chr16:72130556 G/T cg16558253 chr16:72132732 DHX38 -0.37 -5.92 -0.31 8.15e-9 Fibrinogen levels; LUSC cis rs354225 0.584 rs6739140 chr2:54823502 C/G cg26097391 chr2:54893211 SPTBN1 0.44 6.62 0.34 1.41e-10 Schizophrenia; LUSC cis rs950027 0.620 rs1145093 chr15:45649813 C/A cg14582100 chr15:45693742 SPATA5L1 0.46 8.62 0.43 2.7e-16 Response to fenofibrate (adiponectin levels); LUSC trans rs853679 1.000 rs2799079 chr6:28235176 A/C cg06606381 chr12:133084897 FBRSL1 -0.56 -6.99 -0.36 1.5e-11 Depression; LUSC cis rs6831352 0.879 rs1984364 chr4:100070783 A/C cg13256891 chr4:100009986 ADH5 -0.49 -6.37 -0.33 6.11e-10 Alcohol dependence; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.14 0.41 8.18e-15 Prudent dietary pattern; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg27249304 chr10:71906591 TYSND1 0.48 6.24 0.32 1.31e-9 Neuroticism; LUSC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg24813613 chr7:1882135 MAD1L1 -0.43 -7.22 -0.37 3.48e-12 Bipolar disorder and schizophrenia; LUSC cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg17845761 chr1:175162550 KIAA0040 -0.32 -6.1 -0.32 2.93e-9 Alcohol dependence; LUSC cis rs12541635 0.966 rs12550587 chr8:106978289 C/T cg10147462 chr8:107024639 NA 0.55 9.54 0.46 3.08e-19 Age of smoking initiation; LUSC cis rs1413885 0.516 rs10789183 chr1:65856779 G/C cg14976592 chr1:65886160 LEPROT;LEPR 0.48 6.89 0.35 2.73e-11 Anticoagulant levels; LUSC trans rs2018683 0.707 rs10279610 chr7:28975696 C/G cg19402173 chr7:128379420 CALU 0.46 7.16 0.36 5.21e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs9467711 0.606 rs9393705 chr6:26361011 G/A cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg11764359 chr7:65958608 NA -0.69 -11.18 -0.52 7.06e-25 Aortic root size; LUSC cis rs7903847 0.656 rs74729163 chr10:99137287 A/C cg08345082 chr10:99160200 RRP12 -0.32 -5.65 -0.3 3.36e-8 Granulocyte percentage of myeloid white cells; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg21575078 chr14:105956409 C14orf80 0.4 6.1 0.32 2.9e-9 Mosquito bite size; LUSC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg20283391 chr11:68216788 NA -0.53 -7.95 -0.4 2.97e-14 Total body bone mineral density; LUSC cis rs6964587 1.000 rs34548928 chr7:91668365 G/A cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.23e-8 Breast cancer; LUSC cis rs8017423 0.967 rs7158180 chr14:90729117 C/T cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01971132 chr11:72492946 STARD10 0.54 6.29 0.33 9.76e-10 Intelligence (multi-trait analysis); LUSC cis rs9837602 1.000 rs4075038 chr3:99680086 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -6.1 -0.32 2.88e-9 Breast cancer; LUSC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg00339695 chr16:24857497 SLC5A11 0.39 6.63 0.34 1.36e-10 Intelligence (multi-trait analysis); LUSC cis rs9430161 0.579 rs7542158 chr1:11040193 G/A cg27631724 chr1:11040367 C1orf127 0.56 10.92 0.51 6.1e-24 Ewing sarcoma; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg26354017 chr1:205819088 PM20D1 0.8 13.77 0.6 1.75e-34 Menarche (age at onset); LUSC cis rs6424115 0.737 rs10917430 chr1:24170458 C/T cg10978503 chr1:24200527 CNR2 -0.45 -9.45 -0.46 5.93e-19 Immature fraction of reticulocytes; LUSC cis rs73198271 0.562 rs79296712 chr8:8659978 G/A cg01851573 chr8:8652454 MFHAS1 0.66 8.94 0.44 2.73e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs600231 0.665 rs1784859 chr11:65220749 A/G cg17120908 chr11:65337727 SSSCA1 0.53 9.49 0.46 4.53e-19 Bone mineral density; LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.9 0.31 9.03e-9 Renal function-related traits (BUN); LUSC cis rs1840108 0.529 rs35192399 chr2:181492583 T/C cg23363182 chr2:181467187 NA -0.46 -5.82 -0.3 1.39e-8 Anti-saccade response; LUSC cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg10978503 chr1:24200527 CNR2 -0.46 -9.52 -0.46 3.6e-19 Immature fraction of reticulocytes; LUSC cis rs921968 0.643 rs678218 chr2:219379709 C/A cg02176678 chr2:219576539 TTLL4 0.6 10.82 0.51 1.34e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs11153306 0.818 rs1476043 chr6:111944979 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.57 -0.34 1.91e-10 Tonsillectomy; LUSC trans rs17685 0.632 rs1859793 chr7:75821283 G/A cg19862616 chr7:65841803 NCRNA00174 1.05 16.96 0.68 5.75e-47 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg06713675 chr4:122721982 EXOSC9 -0.46 -8.04 -0.4 1.62e-14 Type 2 diabetes; LUSC cis rs1014246 0.848 rs10787714 chr10:118459384 G/T cg14919929 chr10:118506882 NA 0.46 7.17 0.37 4.93e-12 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.82 0.65 1.76e-42 Bladder cancer; LUSC cis rs12618769 0.543 rs6753380 chr2:99129040 A/G cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.12e-13 Bipolar disorder; LUSC cis rs4285028 0.699 rs2689290 chr3:121585146 C/T cg11130432 chr3:121712080 ILDR1 -0.57 -9.01 -0.44 1.63e-17 Multiple sclerosis; LUSC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.5 8.76 0.43 9.9900000000000006e-17 Total body bone mineral density; LUSC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg15145296 chr3:125709740 NA -0.56 -6.66 -0.34 1.1e-10 Blood pressure (smoking interaction); LUSC cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg08807101 chr21:30365312 RNF160 -0.69 -12.08 -0.55 3.97e-28 Dental caries; LUSC cis rs1595825 0.891 rs16867018 chr2:198521490 C/T cg19156104 chr2:198669113 PLCL1 -0.45 -5.69 -0.3 2.74e-8 Ulcerative colitis; LUSC cis rs71403859 0.502 rs34380814 chr16:71488175 C/T cg08717414 chr16:71523259 ZNF19 -0.7 -8.56 -0.42 4.22e-16 Post bronchodilator FEV1; LUSC cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.94 -0.36 2.04e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs6951245 0.554 rs10246354 chr7:1132456 C/T cg13565492 chr6:43139072 SRF -0.72 -10.08 -0.48 4.93e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1964356 0.524 rs7839585 chr8:8854235 C/G cg11995313 chr8:8860691 ERI1 0.35 5.73 0.3 2.2e-8 Mean corpuscular volume; LUSC cis rs72781680 1.000 rs12616985 chr2:24165511 A/C cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg19748678 chr4:122722346 EXOSC9 0.48 7.29 0.37 2.22e-12 Type 2 diabetes; LUSC cis rs656319 0.513 rs6985941 chr8:9983179 C/T cg27411982 chr8:10470053 RP1L1 -0.39 -5.8 -0.3 1.54e-8 Myopia (pathological); LUSC cis rs367615 0.537 rs1965670 chr5:108649798 A/T cg17395555 chr5:108820864 NA -0.45 -8.17 -0.41 6.58e-15 Colorectal cancer (SNP x SNP interaction); LUSC cis rs500891 0.547 rs1144178 chr6:84029716 A/G cg08257003 chr6:84140564 ME1 0.34 8.05 0.4 1.43e-14 Platelet-derived growth factor BB levels; LUSC cis rs11992162 0.636 rs4841645 chr8:11798684 G/T cg21775007 chr8:11205619 TDH -0.48 -6.62 -0.34 1.44e-10 Monocyte count; LUSC trans rs634534 0.563 rs470192 chr11:65724291 C/T cg17712092 chr4:129076599 LARP1B 0.73 10.83 0.51 1.25e-23 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02067639 chr14:71067412 MED6 -0.41 -6.1 -0.32 2.85e-9 Electrocardiographic conduction measures; LUSC cis rs11098499 0.644 rs34835603 chr4:120553428 C/T cg09307838 chr4:120376055 NA 0.65 9.89 0.48 2.06e-20 Corneal astigmatism; LUSC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -9.73 -0.47 7.1e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9640161 0.617 rs73170169 chr7:150008036 G/A cg21361702 chr7:150065534 REPIN1 0.46 6.18 0.32 1.9e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs17255340 0.539 rs4706990 chr6:84108065 A/T cg08257003 chr6:84140564 ME1 -0.34 -8.32 -0.41 2.23e-15 Platelet-derived growth factor BB levels; LUSC cis rs7582180 0.630 rs13021801 chr2:100935129 C/A cg14675211 chr2:100938903 LONRF2 0.37 5.77 0.3 1.78e-8 Intelligence (multi-trait analysis); LUSC cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg23649088 chr2:200775458 C2orf69 -0.47 -6.31 -0.33 8.98e-10 Schizophrenia; LUSC cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg08754478 chr10:133766260 PPP2R2D -0.62 -7.82 -0.39 6.87e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg26384229 chr12:38710491 ALG10B 0.89 16.73 0.68 4.41e-46 Heart rate; LUSC cis rs9303401 0.659 rs72828726 chr17:56951217 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.92 0.58 3.1e-31 Cognitive test performance; LUSC cis rs9790314 1.000 rs9790314 chr3:161019558 T/C cg03342759 chr3:160939853 NMD3 -0.51 -8.7 -0.43 1.59e-16 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC trans rs7939886 0.841 rs79902631 chr11:55995241 A/C cg15704280 chr7:45808275 SEPT13 0.9 6.77 0.35 5.92e-11 Myopia (pathological); LUSC cis rs1981331 1.000 rs118078026 chr21:48012129 T/C cg17243659 chr21:48055224 PRMT2 0.86 6.24 0.32 1.31e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs2730245 0.527 rs712197 chr7:158660846 C/G cg11984989 chr7:158649758 WDR60 1.13 13.89 0.6 6.42e-35 Height; LUSC cis rs34172651 0.917 rs11074654 chr16:24813743 A/G cg06028605 chr16:24865363 SLC5A11 0.48 8.67 0.43 1.97e-16 Intelligence (multi-trait analysis); LUSC cis rs4974559 0.739 rs28573879 chr4:1285910 C/T cg02980000 chr4:1222292 CTBP1 1.02 9.35 0.46 1.28e-18 Systolic blood pressure; LUSC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg02782426 chr3:40428986 ENTPD3 -0.35 -6.91 -0.35 2.48e-11 Renal cell carcinoma; LUSC cis rs1413885 0.502 rs7545397 chr1:65856282 C/A cg14976592 chr1:65886160 LEPROT;LEPR 0.48 7.0 0.36 1.37e-11 Anticoagulant levels; LUSC cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg03433033 chr1:76189801 ACADM -0.44 -6.7 -0.34 9.05e-11 Daytime sleep phenotypes; LUSC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg15921436 chr17:44337874 NA -0.7 -10.6 -0.5 7.91e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.62 0.43 2.69e-16 Prudent dietary pattern; LUSC cis rs533581 0.873 rs579740 chr16:88973937 A/G cg08484992 chr16:88977278 CBFA2T3 -0.4 -7.28 -0.37 2.36e-12 Social autistic-like traits; LUSC cis rs34779708 0.931 rs4934724 chr10:35393669 C/T cg04310649 chr10:35416472 CREM -0.43 -6.56 -0.34 2.09e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs782590 0.517 rs13013133 chr2:55889466 G/A cg03859395 chr2:55845619 SMEK2 -0.63 -8.85 -0.44 5.26e-17 Metabolic syndrome; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.48 6.88 0.35 2.93e-11 Renal function-related traits (BUN); LUSC cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg26384229 chr12:38710491 ALG10B 0.66 10.48 0.5 2.06e-22 Morning vs. evening chronotype; LUSC cis rs9677476 1.000 rs6724253 chr2:232121998 A/G cg07929768 chr2:232055508 NA 0.3 5.7 0.3 2.69e-8 Food antigen IgG levels; LUSC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25152348 chr22:50946712 NCAPH2;LMF2 0.39 6.51 0.34 2.77e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.35 0.46 1.27e-18 Arsenic metabolism; LUSC trans rs75804782 0.641 rs3769124 chr2:239349362 G/A cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.11e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg16423285 chr20:60520624 NA -0.47 -5.94 -0.31 6.99e-9 Body mass index; LUSC cis rs3135063 0.504 rs78139882 chr4:3287361 C/T cg08817983 chr4:3391423 RGS12 -0.45 -6.42 -0.33 4.67e-10 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09512322 chr16:31085976 ZNF668;ZNF646 -0.44 -6.72 -0.35 7.89e-11 Electrocardiographic conduction measures; LUSC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg11764359 chr7:65958608 NA 0.71 10.77 0.51 1.99e-23 Aortic root size; LUSC cis rs9329221 0.527 rs34308302 chr8:10332022 C/T cg21775007 chr8:11205619 TDH -0.44 -5.96 -0.31 6.24e-9 Neuroticism; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg02018176 chr4:1364513 KIAA1530 0.47 8.21 0.41 4.75e-15 Obesity-related traits; LUSC cis rs5167 0.536 rs1882752 chr19:45461342 G/C cg25746394 chr19:45450501 APOC2 0.33 6.03 0.31 4.29e-9 Blood protein levels; LUSC cis rs3764021 1.000 rs3764021 chr12:9833628 C/T cg20894963 chr12:9885564 CLECL1 0.3 6.2 0.32 1.63e-9 Type 1 diabetes; LUSC cis rs79911532 0.515 rs8509 chr7:75616577 G/A cg03592824 chr7:75666768 STYXL1 0.64 6.4 0.33 5.28e-10 Mononucleosis; LUSC cis rs2502731 0.561 rs3003606 chr9:130982416 C/T cg13642260 chr9:130955380 CIZ1 0.51 8.1 0.41 1.01e-14 Attention deficit hyperactivity disorder; LUSC cis rs10208940 0.920 rs13417100 chr2:68821725 C/T cg12452813 chr2:68675892 NA -0.55 -5.75 -0.3 2.03e-8 Urate levels in lean individuals; LUSC cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.27 0.52 3.44e-25 Menopause (age at onset); LUSC cis rs12900413 0.687 rs12902809 chr15:90305617 C/G cg24249390 chr15:90295951 MESP1 -0.36 -5.81 -0.3 1.45e-8 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs2197308 0.765 rs11182992 chr12:37935572 G/C cg06521331 chr12:34319734 NA -0.4 -6.02 -0.31 4.48e-9 Morning vs. evening chronotype; LUSC cis rs7584330 0.518 rs74003104 chr2:238446823 C/T cg14458575 chr2:238380390 NA 0.58 6.82 0.35 4.36e-11 Prostate cancer; LUSC cis rs6964587 1.000 rs1063243 chr7:91726927 A/C cg22709100 chr7:91322751 NA 0.4 5.9 0.31 8.7e-9 Breast cancer; LUSC cis rs2637266 0.783 rs860165 chr10:78492807 A/G cg18941641 chr10:78392320 NA 0.39 7.1 0.36 7.32e-12 Pulmonary function; LUSC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 11.02 0.52 2.78e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10911232 0.507 rs10797833 chr1:183044067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 10.96 0.51 4.32e-24 Hypertriglyceridemia; LUSC trans rs6076960 0.684 rs3844461 chr20:6253115 G/A cg17788362 chr6:86352627 SYNCRIP 0.46 6.79 0.35 5e-11 Smooth-surface caries; LUSC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg13866156 chr1:1669148 SLC35E2 0.53 8.7 0.43 1.59e-16 Body mass index; LUSC cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg13319975 chr6:146136371 FBXO30 -0.53 -7.95 -0.4 2.94e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg21535247 chr6:8435926 SLC35B3 0.58 9.02 0.44 1.46e-17 Motion sickness; LUSC cis rs10492096 1.000 rs12422771 chr12:6580273 G/T cg13857086 chr12:6580257 VAMP1 0.84 9.31 0.45 1.73e-18 Hip geometry; LUSC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg12751644 chr20:60527061 NA -0.33 -6.0 -0.31 5.13e-9 Body mass index; LUSC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg26513180 chr16:89883248 FANCA -0.55 -8.53 -0.42 5.07e-16 Vitiligo; LUSC cis rs3125734 0.582 rs7904465 chr10:64002393 G/A cg19640130 chr10:64028056 RTKN2 -0.41 -7.25 -0.37 2.9e-12 Rheumatoid arthritis; LUSC cis rs10088262 0.629 rs7828192 chr8:124804669 C/T cg20713898 chr8:124780851 FAM91A1 -0.54 -7.62 -0.38 2.65e-13 Pancreatic cancer; LUSC cis rs12681287 0.605 rs13262672 chr8:87355812 T/C cg27223183 chr8:87520930 FAM82B -0.54 -7.15 -0.36 5.47e-12 Caudate activity during reward; LUSC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.53 9.6 0.46 2.02e-19 Bipolar disorder; LUSC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.61 9.26 0.45 2.5e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6696846 0.765 rs72757524 chr1:205086473 C/T cg03948781 chr1:205179583 DSTYK 0.33 6.32 0.33 8.42e-10 Red blood cell count; LUSC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.14 -0.32 2.35e-9 Life satisfaction; LUSC cis rs7100689 0.646 rs1047952 chr10:82126808 C/G cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg14895029 chr7:2775587 GNA12 -0.42 -6.37 -0.33 6.42e-10 Height; LUSC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg00012203 chr2:219082015 ARPC2 0.7 11.55 0.53 3.58e-26 Colorectal cancer; LUSC cis rs12286929 0.637 rs3802858 chr11:115078492 T/C cg04055981 chr11:115044050 NA -0.39 -6.61 -0.34 1.55e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4604732 0.631 rs76761880 chr1:247626377 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22857025 chr5:266934 NA -1.16 -14.37 -0.62 8.82e-37 Breast cancer; LUSC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg06634786 chr22:41940651 POLR3H -0.53 -6.43 -0.33 4.33e-10 Vitiligo; LUSC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg21724239 chr8:58056113 NA 0.59 6.83 0.35 3.92e-11 Developmental language disorder (linguistic errors); LUSC cis rs7833790 0.724 rs6473299 chr8:82676936 A/G cg17211192 chr8:82754475 SNX16 -0.75 -9.94 -0.48 1.47e-20 Diastolic blood pressure; LUSC cis rs603446 0.678 rs664059 chr11:116642137 C/T cg08985259 chr11:116699649 APOC3 -0.27 -6.1 -0.32 2.87e-9 Triglycerides; LUSC cis rs8028313 0.731 rs4331293 chr15:67987801 A/G cg05925327 chr15:68127851 NA -0.4 -6.24 -0.32 1.35e-9 Obesity; LUSC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.81e-12 Depression; LUSC cis rs7100689 0.753 rs1856773 chr10:82060484 T/A cg01528321 chr10:82214614 TSPAN14 0.98 14.61 0.62 1.03e-37 Post bronchodilator FEV1; LUSC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg26695010 chr11:65641043 EFEMP2 -0.46 -7.09 -0.36 7.8e-12 Eosinophil percentage of white cells; LUSC cis rs26868 0.766 rs30995 chr16:2248017 C/T cg27608139 chr16:2294856 DCI -0.32 -5.66 -0.3 3.31e-8 Height; LUSC cis rs459571 0.959 rs465724 chr9:136910097 C/T cg01294253 chr9:136912663 BRD3 0.38 6.73 0.35 7.26e-11 Platelet distribution width; LUSC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg13114125 chr14:105738426 BRF1 -0.95 -16.26 -0.66 3.36e-44 Mean platelet volume;Platelet distribution width; LUSC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg06637938 chr14:75390232 RPS6KL1 -0.52 -8.39 -0.42 1.36e-15 Height; LUSC trans rs35110281 0.805 rs3788062 chr21:44991159 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.55 0.46 2.86e-19 Mean corpuscular volume; LUSC cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg24812749 chr6:127587940 RNF146 0.68 9.68 0.47 1.07e-19 Breast cancer; LUSC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg06634786 chr22:41940651 POLR3H -0.54 -6.98 -0.36 1.57e-11 Vitiligo; LUSC trans rs3808502 0.503 rs2061830 chr8:11397457 C/G cg15556689 chr8:8085844 FLJ10661 0.63 9.88 0.48 2.28e-20 Neuroticism; LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg07677032 chr17:61819896 STRADA 0.54 8.97 0.44 2.22e-17 Prudent dietary pattern; LUSC cis rs61931739 0.929 rs2389274 chr12:34075149 T/C cg06521331 chr12:34319734 NA 0.37 6.27 0.32 1.09e-9 Morning vs. evening chronotype; LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs4917300 0.605 rs1388800 chr8:143106264 C/T cg25363559 chr8:143086065 NA 0.27 6.16 0.32 2.12e-9 Amyotrophic lateral sclerosis; LUSC cis rs7119167 0.636 rs56397594 chr11:73038579 T/C cg17517138 chr11:73019481 ARHGEF17 0.5 5.85 0.3 1.16e-8 Blood protein levels; LUSC cis rs7584330 0.518 rs11884238 chr2:238424671 T/G cg14458575 chr2:238380390 NA 0.44 5.77 0.3 1.78e-8 Prostate cancer; LUSC cis rs9733 0.635 rs486836 chr1:150875967 A/T cg04414720 chr1:150670196 GOLPH3L -0.44 -6.96 -0.36 1.77e-11 Tonsillectomy; LUSC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg01416388 chr22:39784598 NA -0.4 -6.05 -0.31 3.8e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg15485101 chr11:133734466 NA -0.42 -7.46 -0.38 7.73e-13 Childhood ear infection; LUSC cis rs754133 0.964 rs736825 chr12:54417576 C/G cg10005224 chr12:54424964 HOXC4;HOXC5 0.41 8.07 0.4 1.28e-14 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index; LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg22920501 chr2:26401640 FAM59B 0.79 11.46 0.53 7.3e-26 Gut microbiome composition (summer); LUSC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg16049864 chr8:95962084 TP53INP1 -0.64 -12.62 -0.57 4.06e-30 Type 2 diabetes; LUSC cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg12935359 chr14:103987150 CKB -0.65 -10.61 -0.5 7.5e-23 Intelligence (multi-trait analysis); LUSC trans rs8072100 0.727 rs4794052 chr17:45769236 T/C cg04995722 chr7:26192034 NFE2L3 -0.42 -6.46 -0.33 3.79e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg05585544 chr11:47624801 NA -0.41 -7.13 -0.36 6.4e-12 Subjective well-being; LUSC cis rs16912285 0.535 rs6484040 chr11:24309809 C/A ch.11.24196551F chr11:24239977 NA 0.91 10.13 0.48 3.43e-21 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs12677618 1.000 rs10092931 chr8:142307201 A/G cg00131261 chr8:142287264 NA -0.34 -5.78 -0.3 1.74e-8 Plateletcrit; LUSC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11644478 chr21:40555479 PSMG1 -0.63 -9.58 -0.46 2.28e-19 Menarche (age at onset); LUSC cis rs1801251 0.964 rs6748027 chr2:233629552 T/C cg08000102 chr2:233561755 GIGYF2 0.7 11.59 0.54 2.41e-26 Coronary artery disease; LUSC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg05368731 chr17:41323189 NBR1 0.84 14.22 0.61 3.22e-36 Menopause (age at onset); LUSC cis rs34172651 0.917 rs200533 chr16:24754771 C/T cg06028605 chr16:24865363 SLC5A11 -0.45 -8.15 -0.41 7.19e-15 Intelligence (multi-trait analysis); LUSC cis rs3768617 0.510 rs2296293 chr1:183095477 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs9549367 0.789 rs3764125 chr13:113897648 A/G cg00898013 chr13:113819073 PROZ 0.56 8.08 0.4 1.2e-14 Platelet distribution width; LUSC cis rs2290159 0.800 rs2290162 chr3:12647457 A/G cg23032965 chr3:12705835 RAF1 0.71 8.68 0.43 1.75e-16 Cholesterol, total; LUSC cis rs7408868 0.908 rs2074619 chr19:15276919 G/A cg14696996 chr19:15285081 NOTCH3 0.99 9.07 0.44 1.06e-17 Pulse pressure; LUSC cis rs35000415 0.938 rs12539476 chr7:128657483 T/C cg19972273 chr7:128594194 NA 0.68 6.9 0.35 2.56e-11 Systemic lupus erythematosus; LUSC cis rs9462027 0.628 rs2814992 chr6:34617144 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.98 -0.31 5.85e-9 Systemic lupus erythematosus; LUSC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg23978390 chr7:1156363 C7orf50 0.48 5.7 0.3 2.68e-8 Bronchopulmonary dysplasia; LUSC cis rs2797160 1.000 rs1739349 chr6:126014984 G/C cg05901451 chr6:126070800 HEY2 0.57 8.65 0.43 2.22e-16 Endometrial cancer; LUSC cis rs4845570 1.000 rs6681093 chr1:151755284 C/G cg07092448 chr1:151763213 TDRKH -1.02 -10.24 -0.49 1.41e-21 Coronary artery disease; LUSC cis rs11098499 0.954 rs67265404 chr4:120359270 C/T cg09307838 chr4:120376055 NA 0.78 11.21 0.52 5.56e-25 Corneal astigmatism; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg03188948 chr7:1209495 NA 0.42 6.21 0.32 1.57e-9 Longevity;Endometriosis; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg16405210 chr4:1374714 KIAA1530 0.55 8.35 0.42 1.86e-15 Obesity-related traits; LUSC cis rs1580019 0.844 rs4723159 chr7:32512804 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.84 12.36 0.56 3.71e-29 Cognitive ability; LUSC cis rs6964587 1.000 rs2282975 chr7:91761638 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.91 0.31 8.61e-9 Breast cancer; LUSC cis rs6906287 0.647 rs6902812 chr6:118936294 A/G cg21191810 chr6:118973309 C6orf204 0.32 5.91 0.31 8.23e-9 Electrocardiographic conduction measures; LUSC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg11752832 chr7:134001865 SLC35B4 0.51 7.74 0.39 1.22e-13 Mean platelet volume; LUSC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg03806693 chr22:41940476 POLR3H -0.96 -13.04 -0.58 1.08e-31 Vitiligo; LUSC cis rs868036 0.718 rs7170185 chr15:68117300 T/A cg05925327 chr15:68127851 NA -0.38 -6.04 -0.31 4.22e-9 Restless legs syndrome; LUSC cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg26373071 chr5:1325741 CLPTM1L 0.43 8.08 0.4 1.17e-14 Lung cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22654626 chr19:18699620 C19orf60 0.49 7.93 0.4 3.38e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.9 0.72 1.12e-54 Chronic sinus infection; LUSC cis rs244731 0.919 rs12652509 chr5:176626441 A/G cg17509989 chr5:176798049 RGS14 -0.67 -9.28 -0.45 2.18e-18 Urate levels in lean individuals; LUSC cis rs10744422 1.000 rs2135014 chr12:123333065 C/T cg25930673 chr12:123319894 HIP1R -0.72 -7.24 -0.37 3.14e-12 Schizophrenia; LUSC cis rs500891 0.574 rs10485147 chr6:84123350 A/T cg08257003 chr6:84140564 ME1 0.37 9.02 0.44 1.56e-17 Platelet-derived growth factor BB levels; LUSC cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg07148914 chr20:33460835 GGT7 0.55 8.35 0.42 1.79e-15 Height; LUSC cis rs9527 0.590 rs2148200 chr10:104879847 C/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -7.85 -0.39 5.54e-14 Chronic sinus infection; LUSC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg06008330 chr7:65541103 ASL 0.39 6.06 0.31 3.62e-9 Aortic root size; LUSC cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg19628046 chr18:33552617 C18orf21 -0.52 -6.36 -0.33 6.55e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg24642439 chr20:33292090 TP53INP2 -0.51 -7.69 -0.39 1.69e-13 Glomerular filtration rate (creatinine); LUSC cis rs35146811 0.538 rs3823642 chr7:99796072 T/C cg13334819 chr7:99746414 C7orf59 -0.5 -6.73 -0.35 7.41e-11 Coronary artery disease; LUSC cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg26061582 chr7:22766209 IL6 0.49 7.45 0.38 7.86e-13 Lung cancer; LUSC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg02079420 chr8:82753780 SNX16 -0.38 -5.79 -0.3 1.64e-8 Diastolic blood pressure; LUSC cis rs1577917 1.000 rs10455455 chr6:86670214 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.84 -0.35 3.68e-11 Response to antipsychotic treatment; LUSC cis rs9308433 0.529 rs4655246 chr1:214502898 G/C cg06198575 chr1:214491504 SMYD2 0.45 7.09 0.36 8.16e-12 IgG glycosylation; LUSC cis rs8114671 0.967 rs6142321 chr20:33788474 G/A cg07148914 chr20:33460835 GGT7 -0.44 -6.52 -0.34 2.66e-10 Height; LUSC cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.18 0.41 5.99e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs34779708 0.931 rs11010125 chr10:35502953 A/G cg03585969 chr10:35415529 CREM 0.64 9.51 0.46 4e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg06145435 chr7:1022769 CYP2W1 0.29 5.96 0.31 6.5e-9 Longevity;Endometriosis; LUSC cis rs1595825 0.786 rs74484541 chr2:198894223 T/C cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC cis rs6987853 0.933 rs6980507 chr8:42383084 A/G cg09913449 chr8:42400586 C8orf40 0.44 7.35 0.37 1.51e-12 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg11764359 chr7:65958608 NA -0.77 -12.69 -0.57 2.12e-30 Aortic root size; LUSC cis rs1408224 0.688 rs1773122 chr13:47222433 A/G cg19833103 chr13:47126551 LRCH1 -0.4 -5.77 -0.3 1.79e-8 QRS complex (12-leadsum); LUSC trans rs2018683 0.621 rs10261556 chr7:28976636 G/T cg19402173 chr7:128379420 CALU -0.52 -7.91 -0.4 3.89e-14 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs12145833 0.538 rs4658547 chr1:243391131 T/G cg02356786 chr1:243265016 LOC731275 -0.63 -5.7 -0.3 2.66e-8 Obesity (early onset extreme); LUSC cis rs12908161 0.959 rs11637728 chr15:85203392 A/T cg17173187 chr15:85201210 NMB 0.53 9.87 0.48 2.46e-20 Schizophrenia; LUSC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg22800045 chr5:56110881 MAP3K1 -0.61 -8.51 -0.42 5.91e-16 Initial pursuit acceleration; LUSC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg19920283 chr7:105172520 RINT1 -0.58 -6.24 -0.32 1.36e-9 Bipolar disorder (body mass index interaction); LUSC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg05555928 chr11:63887634 MACROD1 0.47 9.0 0.44 1.8e-17 Platelet count; LUSC cis rs568617 0.626 rs10896050 chr11:65577516 G/T cg04055107 chr11:65626734 MUS81;CFL1 0.52 6.31 0.33 9.12e-10 Crohn's disease; LUSC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.49 0.33 3.13e-10 Melanoma; LUSC cis rs9308433 0.643 rs955920 chr1:214464309 G/A cg06198575 chr1:214491504 SMYD2 0.44 6.73 0.35 7.55e-11 IgG glycosylation; LUSC cis rs4851254 0.626 rs13001783 chr2:100689652 A/T cg07810366 chr2:100720526 AFF3 -0.45 -6.06 -0.31 3.7e-9 Intelligence (multi-trait analysis); LUSC cis rs6547741 0.935 rs6761095 chr2:27778010 G/T cg12559939 chr2:27858050 GPN1 0.39 6.03 0.31 4.3e-9 Oral cavity cancer; LUSC cis rs1801251 1.000 rs283476 chr2:233650168 A/G cg25237894 chr2:233734115 C2orf82 0.35 5.98 0.31 5.84e-9 Coronary artery disease; LUSC cis rs6500395 1.000 rs8058362 chr16:48645316 T/C cg04672837 chr16:48644449 N4BP1 0.48 7.06 0.36 9.74e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg26384229 chr12:38710491 ALG10B 0.88 14.52 0.62 2.28e-37 Bladder cancer; LUSC cis rs975210 0.652 rs4777230 chr15:70365762 A/G cg01666796 chr15:70364327 TLE3 -0.66 -7.42 -0.38 9.78e-13 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; LUSC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg12463550 chr7:65579703 CRCP -0.44 -6.55 -0.34 2.18e-10 Aortic root size; LUSC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg26850624 chr5:429559 AHRR -0.37 -6.76 -0.35 6.09e-11 Cystic fibrosis severity; LUSC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg21926612 chr6:163149169 PACRG;PARK2 1.19 15.61 0.65 1.22e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9486719 0.948 rs2499817 chr6:96878321 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs977987 0.815 rs11149821 chr16:75422817 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.2 -0.37 4.07e-12 Dupuytren's disease; LUSC cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg24642439 chr20:33292090 TP53INP2 0.73 12.12 0.55 2.84e-28 Coronary artery disease; LUSC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg11062466 chr8:58055876 NA 0.49 6.49 0.33 3.19e-10 Developmental language disorder (linguistic errors); LUSC cis rs4919694 1.000 rs11191525 chr10:104793435 G/C cg23093090 chr10:104574429 C10orf26 -0.47 -5.76 -0.3 1.94e-8 Arsenic metabolism; LUSC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg11247378 chr22:39784982 NA -0.67 -13.68 -0.6 3.81e-34 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg12419862 chr22:24373484 LOC391322 -0.87 -14.28 -0.62 1.84e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs561341 1.000 rs1557731 chr17:30321567 T/G cg27661571 chr11:113659931 NA -0.62 -7.45 -0.38 8.21e-13 Hip circumference adjusted for BMI; LUSC cis rs2295359 0.824 rs11209003 chr1:67601132 G/T cg17031739 chr1:67600172 NA 0.49 7.59 0.38 3.26e-13 Psoriasis; LUSC trans rs12682352 0.715 rs332039 chr8:8723651 C/G cg27411982 chr8:10470053 RP1L1 0.43 6.49 0.33 3.05e-10 Neuroticism; LUSC cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg24812749 chr6:127587940 RNF146 0.92 13.86 0.6 7.98e-35 Breast cancer; LUSC cis rs12421382 0.659 rs35527696 chr11:109379944 T/A cg11473876 chr11:109292803 C11orf87 0.39 6.32 0.33 8.41e-10 Schizophrenia; LUSC cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg04450456 chr4:17643702 FAM184B 0.39 6.65 0.34 1.18e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2635047 0.777 rs9944807 chr18:44788908 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.67 0.3 3.02e-8 Educational attainment; LUSC trans rs7395662 0.571 rs10838947 chr11:48568693 G/T cg15704280 chr7:45808275 SEPT13 -0.46 -6.35 -0.33 6.87e-10 HDL cholesterol; LUSC cis rs7246967 0.611 rs62118780 chr19:22831114 C/G cg23217946 chr19:22817039 ZNF492 0.45 6.04 0.31 4.09e-9 Bronchopulmonary dysplasia; LUSC cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg00990874 chr7:1149470 C7orf50 -0.6 -7.7 -0.39 1.56e-13 Bronchopulmonary dysplasia; LUSC cis rs3931020 0.688 rs277375 chr1:75204143 A/G cg10128416 chr1:75198403 TYW3;CRYZ 0.58 7.87 0.4 4.88e-14 Resistin levels; LUSC cis rs7119 0.635 rs2667767 chr15:77876031 T/C cg27398640 chr15:77910606 LINGO1 0.37 8.52 0.42 5.44e-16 Type 2 diabetes; LUSC cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg18681998 chr4:17616180 MED28 0.81 13.89 0.61 5.89e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12620999 1.000 rs4377286 chr2:238069686 C/T cg23555395 chr2:238036564 NA -0.47 -8.25 -0.41 3.6e-15 Systemic lupus erythematosus; LUSC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg16362232 chr11:430036 ANO9 0.66 8.14 0.41 7.98e-15 Body mass index; LUSC cis rs1568889 1.000 rs16917689 chr11:28064466 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC cis rs7615316 1.000 rs9862919 chr3:142341146 G/A cg16271453 chr3:142027066 XRN1 -0.36 -6.2 -0.32 1.64e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11098499 0.954 rs17005535 chr4:120411562 C/T cg09307838 chr4:120376055 NA 0.8 11.8 0.54 4.09e-27 Corneal astigmatism; LUSC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg12463550 chr7:65579703 CRCP -0.55 -8.16 -0.41 6.86e-15 Aortic root size; LUSC cis rs500891 0.574 rs13214484 chr6:84133338 T/C cg08257003 chr6:84140564 ME1 0.36 8.59 0.43 3.3e-16 Platelet-derived growth factor BB levels; LUSC cis rs10489202 0.657 rs201540 chr1:167992883 G/A cg24449463 chr1:168025552 DCAF6 -0.79 -13.4 -0.59 4.64e-33 Schizophrenia; LUSC trans rs11764590 0.585 rs11772463 chr7:2078132 A/C cg25206134 chr2:45395956 NA 0.6 6.51 0.34 2.73e-10 Neuroticism; LUSC trans rs9409565 0.826 rs9409546 chr9:97209066 T/C cg05679027 chr9:99775184 HIATL2 -0.49 -7.07 -0.36 9.02e-12 Colorectal cancer (alcohol consumption interaction); LUSC cis rs12908161 0.853 rs12912342 chr15:85248216 T/C cg12863693 chr15:85201151 NMB 0.35 7.57 0.38 3.56e-13 Schizophrenia; LUSC cis rs6076065 0.723 rs6137922 chr20:23363773 G/A cg11657817 chr20:23433608 CST11 0.43 8.09 0.4 1.11e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs1355223 0.752 rs286893 chr11:34674882 C/G cg11058730 chr11:34937778 PDHX;APIP 0.43 6.08 0.32 3.22e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.82 -12.89 -0.58 3.76e-31 Cognitive test performance; LUSC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -6.1 -0.32 2.9e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg17971929 chr21:40555470 PSMG1 0.74 12.6 0.57 4.88e-30 Cognitive function; LUSC cis rs17604090 0.756 rs10249388 chr7:29729135 G/T cg19413766 chr7:29689036 LOC646762 -0.66 -7.92 -0.4 3.48e-14 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg08975724 chr8:8085496 FLJ10661 0.57 8.63 0.43 2.47e-16 Mood instability; LUSC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg12463550 chr7:65579703 CRCP 0.42 6.01 0.31 4.78e-9 Calcium levels; LUSC cis rs10992471 0.528 rs10514815 chr9:95256695 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.35 -6.02 -0.31 4.68e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7098414 0.511 rs4934134 chr10:82160582 C/T cg00277334 chr10:82204260 NA -0.6 -9.92 -0.48 1.64e-20 Post bronchodilator FEV1; LUSC cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg08085267 chr17:45401833 C17orf57 0.5 6.99 0.36 1.54e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs546131 0.928 rs499183 chr11:34836678 A/G cg11058730 chr11:34937778 PDHX;APIP 0.46 6.33 0.33 7.7e-10 Lung disease severity in cystic fibrosis; LUSC cis rs12971120 0.838 rs2241510 chr18:72180739 G/A cg26446133 chr18:72167187 CNDP2 -0.77 -9.1 -0.45 8.32e-18 Refractive error; LUSC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.74 -0.3 2.14e-8 Parkinson's disease; LUSC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.4 0.38 1.12e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9300255 0.510 rs1727323 chr12:123698790 T/C cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC trans rs2243480 1.000 rs778691 chr7:65873092 G/C cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC cis rs17401966 0.867 rs61775872 chr1:10279308 T/C cg19773385 chr1:10388646 KIF1B -0.51 -8.52 -0.42 5.74e-16 Hepatocellular carcinoma; LUSC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg25124228 chr12:125621409 AACS 0.46 7.64 0.39 2.3e-13 Post bronchodilator FEV1/FVC ratio; LUSC cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg06627628 chr2:24431161 ITSN2 -0.89 -12.86 -0.58 5.17e-31 Asthma; LUSC cis rs17270561 0.609 rs9358886 chr6:25758253 T/A cg17691542 chr6:26056736 HIST1H1C 0.57 7.7 0.39 1.6e-13 Iron status biomarkers; LUSC cis rs9547692 0.938 rs55639205 chr13:37469994 A/C cg01493522 chr13:37497338 NA -0.44 -6.28 -0.32 1.07e-9 Coronary artery disease; LUSC cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg03146154 chr1:46216737 IPP -0.5 -7.19 -0.37 4.3e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8077889 1.000 rs113919636 chr17:41877740 A/C cg26893861 chr17:41843967 DUSP3 0.89 13.09 0.58 7.03e-32 Triglycerides; LUSC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC trans rs3857536 0.813 rs7771716 chr6:66946769 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg21681030 chr2:46777652 RHOQ 0.49 6.84 0.35 3.84e-11 Height; LUSC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg04727924 chr7:799746 HEATR2 -0.57 -5.98 -0.31 5.74e-9 Cerebrospinal P-tau181p levels; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg25703541 chr22:24373054 LOC391322 -0.92 -16.67 -0.67 7.97e-46 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg26384229 chr12:38710491 ALG10B 0.9 14.1 0.61 9.62e-36 Bladder cancer; LUSC cis rs28830936 0.966 rs17733613 chr15:41917585 A/G cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.27 -0.32 1.13e-9 Diastolic blood pressure; LUSC cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg06550200 chr5:1325588 CLPTM1L -0.57 -9.66 -0.47 1.29e-19 Lung cancer; LUSC trans rs2797160 1.000 rs2211420 chr6:125995549 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.76 -0.35 6.14e-11 Endometrial cancer; LUSC cis rs11098499 0.954 rs11098525 chr4:120390152 G/A cg24375607 chr4:120327624 NA 0.79 11.68 0.54 1.17e-26 Corneal astigmatism; LUSC cis rs763121 0.819 rs5757161 chr22:38990662 G/A cg06022373 chr22:39101656 GTPBP1 0.79 13.25 0.59 1.76e-32 Menopause (age at onset); LUSC cis rs716316 0.590 rs6135309 chr20:14902522 C/T cg04470754 chr20:14904432 MACROD2 -0.5 -8.08 -0.4 1.19e-14 Advanced glycation end-product levels; LUSC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg03354898 chr7:1950403 MAD1L1 -0.45 -8.92 -0.44 3.02e-17 Bipolar disorder and schizophrenia; LUSC cis rs909341 0.909 rs1295810 chr20:62330484 G/A cg09650180 chr20:62225654 GMEB2 -0.44 -5.72 -0.3 2.35e-8 Atopic dermatitis; LUSC cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg22676075 chr6:135203613 NA 0.58 9.02 0.44 1.46e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg18765753 chr7:1198926 ZFAND2A -0.41 -7.13 -0.36 6.08e-12 Longevity;Endometriosis; LUSC cis rs4566357 1.000 rs10933167 chr2:227925969 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.89 -0.31 9.43e-9 Coronary artery disease; LUSC cis rs7523050 0.643 rs34096625 chr1:109401101 G/A cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs6740322 0.748 rs6756625 chr2:43489313 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.49 6.52 0.34 2.54e-10 Coronary artery disease; LUSC trans rs13130787 0.966 rs13105254 chr4:94842776 C/T cg00867694 chr14:91884854 CCDC88C -0.4 -6.29 -0.33 9.99e-10 Colorectal cancer; LUSC cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg22117172 chr7:91764530 CYP51A1 0.32 5.71 0.3 2.53e-8 Breast cancer; LUSC cis rs920590 0.684 rs59565447 chr8:19668430 A/T cg03894339 chr8:19674705 INTS10 0.58 7.84 0.39 5.95e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs3931020 0.688 rs405445 chr1:75221150 C/T cg10128416 chr1:75198403 TYW3;CRYZ -0.63 -8.61 -0.43 2.95e-16 Resistin levels; LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg09177884 chr7:1199841 ZFAND2A -0.43 -6.18 -0.32 1.89e-9 Longevity;Endometriosis; LUSC trans rs9291683 0.546 rs6829727 chr4:10051672 A/C cg26043149 chr18:55253948 FECH 0.48 7.14 0.36 5.91e-12 Bone mineral density; LUSC cis rs9831754 0.906 rs7611939 chr3:78392751 A/C cg06138941 chr3:78371609 NA -0.66 -8.99 -0.44 1.87e-17 Calcium levels; LUSC cis rs838147 0.760 rs281408 chr19:49233406 A/C cg21064579 chr19:49206444 FUT2 0.33 5.7 0.3 2.7e-8 Dietary macronutrient intake; LUSC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg24733560 chr20:60626293 TAF4 0.38 6.26 0.32 1.18e-9 Body mass index; LUSC trans rs7916697 0.626 rs61854803 chr10:70014638 T/C cg04882175 chr6:131122610 NA -0.51 -6.84 -0.35 3.83e-11 Optic disc area; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00435006 chr16:1877199 HAGH;FAHD1 -0.46 -6.32 -0.33 8.14e-10 Hepatitis; LUSC cis rs501916 0.796 rs75186419 chr15:48043934 G/A cg16110827 chr15:48056943 SEMA6D -0.46 -7.05 -0.36 1.03e-11 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg21724239 chr8:58056113 NA -0.88 -9.74 -0.47 6.52e-20 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg24675658 chr1:53192096 ZYG11B 0.57 8.97 0.44 2.12e-17 Monocyte count; LUSC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg17554472 chr22:41940697 POLR3H -0.47 -5.75 -0.3 2.03e-8 Vitiligo; LUSC cis rs7191700 0.674 rs12597893 chr16:11426331 A/G cg00044050 chr16:11439710 C16orf75 0.74 13.97 0.61 3.11e-35 Multiple sclerosis; LUSC cis rs2637266 0.935 rs2579727 chr10:78395497 A/C cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.95e-13 Pulmonary function; LUSC trans rs2243480 1.000 rs4718333 chr7:65772758 T/C cg10756647 chr7:56101905 PSPH -0.86 -8.52 -0.42 5.52e-16 Diabetic kidney disease; LUSC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg07701084 chr6:150067640 NUP43 0.5 7.44 0.38 8.36e-13 Lung cancer; LUSC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg00522288 chr12:125625016 AACS -0.31 -5.74 -0.3 2.14e-8 Post bronchodilator FEV1/FVC ratio; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg04207045 chr7:99647562 ZSCAN21 0.41 6.35 0.33 7.21e-10 Mosquito bite size; LUSC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg03806693 chr22:41940476 POLR3H 0.97 14.15 0.61 6.21e-36 Vitiligo; LUSC cis rs4969178 0.930 rs12452576 chr17:76386037 A/C cg20026190 chr17:76395443 PGS1 0.44 7.75 0.39 1.11e-13 HDL cholesterol levels; LUSC cis rs6424115 0.830 rs1105 chr1:24200800 T/C cg15997130 chr1:24165203 NA 0.52 8.58 0.43 3.6e-16 Immature fraction of reticulocytes; LUSC cis rs2235544 0.565 rs635059 chr1:54469120 G/C cg25741118 chr1:54482237 LDLRAD1 0.28 6.04 0.31 4.04e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs6460942 0.591 rs10262667 chr7:12385391 C/T cg06484146 chr7:12443880 VWDE -0.52 -6.38 -0.33 5.87e-10 Coronary artery disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11686214 chr19:59084984 MZF1;LOC100131691 -0.45 -6.93 -0.35 2.11e-11 Electrocardiographic conduction measures; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg04267008 chr7:1944627 MAD1L1 -0.59 -9.09 -0.45 8.97e-18 Bipolar disorder and schizophrenia; LUSC cis rs2839186 0.934 rs4819221 chr21:47695417 G/T cg13126279 chr21:47581558 C21orf56 0.43 6.4 0.33 5.27e-10 Testicular germ cell tumor; LUSC cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg06784218 chr1:46089804 CCDC17 0.56 11.13 0.52 1.11e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg00603717 chr13:46039090 COG3 0.42 6.08 0.32 3.31e-9 Eotaxin levels; LUSC cis rs6430585 0.527 rs961360 chr2:136393658 A/G cg07169764 chr2:136633963 MCM6 1.07 13.98 0.61 2.71e-35 Corneal structure; LUSC cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg19077165 chr18:44547161 KATNAL2 -0.42 -6.07 -0.32 3.47e-9 Personality dimensions; LUSC cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg18132916 chr6:79620363 NA -0.41 -6.3 -0.33 9.63e-10 Intelligence (multi-trait analysis); LUSC cis rs5758511 0.731 rs5751186 chr22:42349710 G/A cg12850546 chr22:42539477 CYP2D7P1 0.47 5.85 0.31 1.14e-8 Birth weight; LUSC trans rs629535 0.821 rs660144 chr8:70035629 T/C cg21567404 chr3:27674614 NA 0.96 15.1 0.64 1.2e-39 Dupuytren's disease; LUSC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg12463550 chr7:65579703 CRCP -0.43 -6.36 -0.33 6.61e-10 Aortic root size; LUSC cis rs3771570 1.000 rs62186422 chr2:242249499 A/G cg21155796 chr2:242212141 HDLBP 0.67 7.52 0.38 5.23e-13 Prostate cancer; LUSC cis rs2637266 0.783 rs1660908 chr10:78494856 T/C cg18941641 chr10:78392320 NA 0.39 7.2 0.37 4.13e-12 Pulmonary function; LUSC cis rs3741151 0.686 rs11823913 chr11:73141627 C/G cg17517138 chr11:73019481 ARHGEF17 0.8 7.35 0.37 1.56e-12 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg18230493 chr5:56204884 C5orf35 -0.89 -13.64 -0.6 5.59e-34 Initial pursuit acceleration; LUSC cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg09904177 chr6:26538194 HMGN4 0.65 11.28 0.53 3.25e-25 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18099408 chr3:52552593 STAB1 -0.37 -6.47 -0.33 3.49e-10 Electroencephalogram traits; LUSC cis rs7586879 0.828 rs13012304 chr2:25122246 C/T cg01884057 chr2:25150051 NA 0.42 8.8 0.43 7.49e-17 Body mass index; LUSC cis rs72781680 0.948 rs72796385 chr2:24170360 T/A cg20701182 chr2:24300061 SF3B14 0.58 6.18 0.32 1.82e-9 Lymphocyte counts; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg21577260 chr17:73285714 SLC25A19 0.49 6.44 0.33 4.11e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7107174 0.901 rs1046780 chr11:77926769 A/G cg02023728 chr11:77925099 USP35 0.5 7.24 0.37 3.18e-12 Testicular germ cell tumor; LUSC cis rs9435341 0.762 rs2878349 chr1:107549245 G/A cg09367891 chr1:107599246 PRMT6 0.46 6.8 0.35 4.93e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg07828024 chr6:149772892 ZC3H12D 0.34 7.31 0.37 1.93e-12 Dupuytren's disease; LUSC trans rs208520 0.690 rs12204512 chr6:66710486 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.85 0.68 1.53e-46 Exhaled nitric oxide output; LUSC cis rs2979489 0.891 rs2979511 chr8:30394968 G/A cg26383811 chr8:30366931 RBPMS -0.52 -8.16 -0.41 6.8e-15 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg26752003 chr8:145688521 CYHR1 -0.59 -10.03 -0.48 7.31e-21 Age at first birth; LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg16325326 chr1:53192061 ZYG11B 0.69 11.18 0.52 7.53e-25 Monocyte count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04297258 chr16:88772664 RNF166;CTU2 0.43 6.19 0.32 1.74e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs72781680 0.898 rs72788214 chr2:24087621 A/C cg20701182 chr2:24300061 SF3B14 0.54 5.73 0.3 2.2e-8 Lymphocyte counts; LUSC cis rs9486719 0.552 rs9399923 chr6:96850379 G/A cg06623918 chr6:96969491 KIAA0776 0.72 9.63 0.47 1.56e-19 Migraine;Coronary artery disease; LUSC cis rs57590327 0.555 rs13072957 chr3:81776242 A/G cg07356753 chr3:81810745 GBE1 0.67 10.71 0.51 3.32e-23 Extraversion; LUSC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg15335139 chr3:50242325 SLC38A3 -0.25 -5.71 -0.3 2.5e-8 Body mass index; LUSC cis rs72781680 0.848 rs72780199 chr2:24016269 A/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg17764715 chr19:33622953 WDR88 0.6 8.81 0.43 6.93e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7193541 0.684 rs4888264 chr16:74681632 T/G cg01733217 chr16:74700730 RFWD3 0.97 22.15 0.77 1.61e-67 Multiple myeloma; LUSC cis rs354225 0.608 rs168505 chr2:54920968 C/T cg26097391 chr2:54893211 SPTBN1 0.34 5.68 0.3 2.88e-8 Schizophrenia; LUSC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg13560548 chr3:10150139 C3orf24 0.53 7.55 0.38 4.21e-13 Alzheimer's disease; LUSC cis rs7267979 1.000 rs6050609 chr20:25411751 A/G cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8078723 1.000 rs4795418 chr17:38164851 T/C cg17467752 chr17:38218738 THRA 0.77 12.45 0.56 1.7e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9549367 0.713 rs1323315 chr13:113859658 T/C cg00898013 chr13:113819073 PROZ 0.55 8.28 0.41 3.02e-15 Platelet distribution width; LUSC trans rs2229238 0.911 rs59838898 chr1:154466301 C/T cg25273160 chr11:56955011 LRRC55 0.31 6.05 0.31 3.81e-9 Coronary heart disease; LUSC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.76 -9.57 -0.46 2.51e-19 Gut microbiome composition (summer); LUSC cis rs977987 0.806 rs4888420 chr16:75462998 G/C cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs7523273 0.606 rs2281289 chr1:207978916 C/T cg22525895 chr1:207977042 MIR29B2 -0.39 -6.27 -0.32 1.09e-9 Schizophrenia; LUSC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg09034736 chr1:150693464 HORMAD1 -0.5 -7.28 -0.37 2.38e-12 Tonsillectomy; LUSC cis rs1670533 1.000 rs688785 chr4:1082707 G/C cg02018176 chr4:1364513 KIAA1530 0.45 6.34 0.33 7.29e-10 Recombination rate (females); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg25783469 chr7:73256908 WBSCR27 0.43 6.7 0.34 9.05e-11 Schizophrenia; LUSC cis rs11122272 0.675 rs1416913 chr1:231533206 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.11 -0.48 3.98e-21 Hemoglobin concentration; LUSC cis rs2692947 0.726 rs13019188 chr2:96774199 A/G cg23100626 chr2:96804247 ASTL -0.26 -6.48 -0.33 3.3e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10927875 0.526 rs35340817 chr1:16178917 T/C cg21385522 chr1:16154831 NA -0.87 -12.57 -0.57 6.19e-30 Dilated cardiomyopathy; LUSC trans rs1864729 1.000 rs2439702 chr8:98272647 C/T cg08679828 chr8:102218111 ZNF706 -0.83 -7.54 -0.38 4.47e-13 Estradiol plasma levels (breast cancer); LUSC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg11663144 chr21:46675770 NA -0.41 -7.03 -0.36 1.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg21770322 chr7:97807741 LMTK2 0.44 7.61 0.38 2.79e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs939574 1.000 rs908196 chr2:220088248 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.96 -8.43 -0.42 1.05e-15 Platelet distribution width; LUSC cis rs6701037 1.000 rs6683533 chr1:175125440 G/A cg17845761 chr1:175162550 KIAA0040 -0.31 -6.0 -0.31 5.07e-9 Alcohol dependence; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg01219670 chr7:76054755 ZP3 0.39 5.97 0.31 6.06e-9 Cognitive function;Information processing speed; LUSC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.93 0.44 2.98e-17 Prudent dietary pattern; LUSC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11644478 chr21:40555479 PSMG1 0.95 18.98 0.72 5.3e-55 Cognitive function; LUSC cis rs3755132 0.568 rs876718 chr2:15808935 A/G cg12888861 chr2:15731646 DDX1 -0.5 -5.68 -0.3 2.86e-8 Wilms tumor; LUSC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg20573242 chr4:122745356 CCNA2 0.43 6.65 0.34 1.19e-10 Type 2 diabetes; LUSC cis rs1018697 0.518 rs284846 chr10:104557290 T/C cg04362960 chr10:104952993 NT5C2 -0.65 -7.73 -0.39 1.31e-13 Colorectal adenoma (advanced); LUSC cis rs17095355 0.584 rs12243027 chr10:111924817 C/T cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.65 -0.34 1.19e-10 Biliary atresia; LUSC cis rs61931739 0.926 rs1995966 chr12:34095420 G/A cg06521331 chr12:34319734 NA 0.4 6.5 0.34 2.87e-10 Morning vs. evening chronotype; LUSC cis rs2932538 0.961 rs10745332 chr1:113189053 G/A cg22162597 chr1:113214053 CAPZA1 -0.68 -9.75 -0.47 6.14e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg25208724 chr1:156163844 SLC25A44 -1.09 -26.84 -0.83 2.17e-85 Testicular germ cell tumor; LUSC trans rs12579753 0.879 rs11115008 chr12:82164859 C/T cg07923666 chr12:49932857 KCNH3 -0.5 -6.36 -0.33 6.67e-10 Resting heart rate; LUSC cis rs4776059 0.916 rs4774636 chr15:52968193 A/C cg22715398 chr15:52968154 KIAA1370 -0.66 -9.09 -0.45 9.04e-18 Schizophrenia; LUSC cis rs28374715 0.578 rs17730888 chr15:41637547 A/G cg18705301 chr15:41695430 NDUFAF1 -1.02 -22.11 -0.77 2.3e-67 Ulcerative colitis; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg23978390 chr7:1156363 C7orf50 0.44 6.29 0.33 1.02e-9 Longevity;Endometriosis; LUSC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -7.9 -0.4 4.1e-14 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7937682 1.000 rs11213973 chr11:111538903 A/T cg18187862 chr3:45730750 SACM1L 0.54 6.86 0.35 3.4e-11 Primary sclerosing cholangitis; LUSC cis rs6696846 0.791 rs7520752 chr1:205054114 C/T cg00857998 chr1:205179979 DSTYK -0.61 -9.48 -0.46 4.87e-19 Red blood cell count; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg12026095 chr19:49468461 FTL -0.5 -7.36 -0.37 1.48e-12 Cognitive function;Information processing speed; LUSC cis rs7584330 0.666 rs1574530 chr2:238395708 A/T cg14458575 chr2:238380390 NA 0.45 5.84 0.3 1.24e-8 Prostate cancer; LUSC cis rs9837602 0.872 rs35154249 chr3:99738230 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg00745463 chr17:30367425 LRRC37B -0.75 -9.11 -0.45 8.01e-18 Hip circumference adjusted for BMI; LUSC cis rs9788682 0.706 rs2568493 chr15:78740233 G/A cg24631222 chr15:78858424 CHRNA5 -0.66 -8.64 -0.43 2.3e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.37 -5.66 -0.3 3.3e-8 Ulcerative colitis; LUSC trans rs7829975 0.514 rs2945873 chr8:8260445 C/T cg21775007 chr8:11205619 TDH 0.41 6.04 0.31 4.05e-9 Mood instability; LUSC cis rs73206853 0.563 rs73194040 chr12:111181106 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.37 0.37 1.38e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg03180552 chr7:157981849 PTPRN2 0.41 7.39 0.37 1.18e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9467711 0.559 rs6920256 chr6:26537801 G/A cg12826209 chr6:26865740 GUSBL1 0.67 5.84 0.3 1.27e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs2898681 0.561 rs2200225 chr4:53738411 A/G cg00791764 chr4:53727839 RASL11B 0.47 7.0 0.36 1.45e-11 Optic nerve measurement (cup area); LUSC cis rs141518190 1 rs141518190 chr15:78900647 A/G cg06917634 chr15:78832804 PSMA4 -0.44 -5.91 -0.31 8.24e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6582630 0.560 rs12315134 chr12:38419857 T/A cg26384229 chr12:38710491 ALG10B -0.55 -8.19 -0.41 5.43e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg24060327 chr5:131705240 SLC22A5 0.67 11.21 0.52 5.78e-25 Blood metabolite levels; LUSC cis rs3768617 0.966 rs6669796 chr1:183082825 G/C ch.1.3577855R chr1:183094577 LAMC1 0.6 8.48 0.42 7.3e-16 Fuchs's corneal dystrophy; LUSC cis rs193541 0.507 rs2407400 chr5:122080600 C/G cg19077854 chr5:122220652 SNX24 -0.27 -6.25 -0.32 1.26e-9 Glucose homeostasis traits; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg06600287 chr1:53387719 ECHDC2 -0.29 -6.31 -0.33 9.06e-10 Monocyte count; LUSC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg06112835 chr11:68658793 MRPL21 0.51 7.81 0.39 7.24e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.9 -0.4 3.96e-14 Personality dimensions; LUSC cis rs977987 0.654 rs8054194 chr16:75497160 G/T cg04384234 chr16:75411784 CFDP1 -0.49 -7.93 -0.4 3.27e-14 Dupuytren's disease; LUSC cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg06454157 chr6:167490870 NA -0.24 -6.04 -0.31 4.19e-9 Crohn's disease; LUSC cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg08754478 chr10:133766260 PPP2R2D -0.62 -8.21 -0.41 4.89e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg25566285 chr7:158114605 PTPRN2 0.32 5.8 0.3 1.56e-8 Calcium levels; LUSC cis rs6733011 0.518 rs12992214 chr2:99466337 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -5.9 -0.31 8.96e-9 Bipolar disorder; LUSC cis rs2970818 0.831 rs11063214 chr12:4635045 A/G cg11146114 chr12:4671731 NA -0.59 -5.88 -0.31 1.01e-8 Phosphorus levels; LUSC cis rs7568458 0.811 rs3755014 chr2:85764006 C/T cg02493740 chr2:85810744 VAMP5 -0.38 -6.67 -0.34 1.04e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg00166722 chr3:10149974 C3orf24 0.58 7.8 0.39 8.09e-14 Alzheimer's disease; LUSC cis rs2290416 0.892 rs59742520 chr8:144676234 G/C cg14809332 chr8:144654887 C8orf73 0.56 6.64 0.34 1.25e-10 Attention deficit hyperactivity disorder; LUSC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21582582 chr3:182698605 DCUN1D1 0.48 8.4 0.42 1.29e-15 Intelligence (multi-trait analysis); LUSC cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg22676075 chr6:135203613 NA 0.59 9.4 0.46 9.14e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg00409905 chr10:38381863 ZNF37A -0.34 -5.65 -0.3 3.53e-8 Breast cancer; LUSC cis rs12586317 0.553 rs78124218 chr14:35570606 G/A cg05294307 chr14:35346193 BAZ1A -0.56 -6.74 -0.35 6.84e-11 Psoriasis; LUSC cis rs4786125 0.587 rs12920700 chr16:6926397 C/T cg03623568 chr16:6915990 A2BP1 -0.48 -8.15 -0.41 7.63e-15 Heart rate variability traits (SDNN); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg11618704 chr10:43904553 HNRNPF 0.45 6.57 0.34 1.98e-10 Triglycerides; LUSC cis rs4474465 1.000 rs2063729 chr11:78185969 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.68 -0.3 2.93e-8 Alzheimer's disease (survival time); LUSC cis rs1150668 0.796 rs1052215 chr6:28348158 T/G cg21251018 chr6:28226885 NKAPL -0.31 -5.77 -0.3 1.82e-8 Pubertal anthropometrics; LUSC cis rs10791323 0.517 rs1120247 chr11:133745180 T/G cg15485101 chr11:133734466 NA 0.35 6.2 0.32 1.66e-9 Childhood ear infection; LUSC cis rs2290159 0.948 rs9852128 chr3:12635623 A/G cg23032965 chr3:12705835 RAF1 0.54 7.03 0.36 1.2e-11 Cholesterol, total; LUSC cis rs66569888 0.632 rs6728600 chr2:106898653 G/T cg16099169 chr2:106886729 NA -0.51 -6.55 -0.34 2.19e-10 Facial morphology (factor 23); LUSC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg06850241 chr22:41845214 NA -0.3 -5.83 -0.3 1.28e-8 Vitiligo; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14524403 chr9:136325208 C9orf7 0.42 6.04 0.31 4.03e-9 Mosquito bite size; LUSC cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg22496339 chr2:162101262 NA 0.52 7.54 0.38 4.48e-13 Intelligence (multi-trait analysis); LUSC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg09238746 chr17:78121135 EIF4A3 -0.6 -8.95 -0.44 2.44e-17 Yeast infection; LUSC cis rs79911532 0.515 rs112615204 chr7:75760909 C/T cg03592824 chr7:75666768 STYXL1 0.67 6.37 0.33 6.32e-10 Mononucleosis; LUSC cis rs9650315 0.866 rs11992729 chr8:57188153 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs983392 0.679 rs654415 chr11:60013674 G/A cg24026212 chr11:59952134 MS4A6A 0.36 6.3 0.33 9.17e-10 Alzheimer's disease (late onset); LUSC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg17507749 chr15:85114479 UBE2QP1 0.54 5.99 0.31 5.56e-9 Schizophrenia; LUSC cis rs7570971 0.500 rs13413101 chr2:135859371 A/T cg07169764 chr2:136633963 MCM6 0.5 6.57 0.34 1.92e-10 Blood metabolite levels;Body mass index;Cholesterol, total; LUSC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg02221750 chr19:17393354 ANKLE1 -0.85 -13.16 -0.58 3.91e-32 Systemic lupus erythematosus; LUSC cis rs80282103 0.764 rs10047383 chr10:1103095 A/G cg08668510 chr10:1095578 IDI1 0.67 5.91 0.31 8.35e-9 Glomerular filtration rate (creatinine); LUSC cis rs7408868 1.000 rs4809029 chr19:15273248 A/C cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.15e-18 Pulse pressure; LUSC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg05472934 chr7:22766657 IL6 0.52 8.08 0.4 1.2e-14 Lung cancer; LUSC cis rs701145 0.878 rs355774 chr3:154036196 A/G cg17054900 chr3:154042577 DHX36 0.84 8.81 0.43 7.07e-17 Coronary artery disease; LUSC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg13206674 chr6:150067644 NUP43 0.6 9.49 0.46 4.58e-19 Lung cancer; LUSC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg22442454 chr1:209979470 IRF6 0.45 6.13 0.32 2.48e-9 Cleft lip with or without cleft palate; LUSC cis rs7712401 0.562 rs62377399 chr5:122324679 G/A cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs5758511 0.514 rs5758626 chr22:42572363 G/A cg00645731 chr22:42541494 CYP2D7P1 0.57 9.7 0.47 8.94e-20 Birth weight; LUSC cis rs6547741 1.000 rs76784350 chr2:27764278 A/G cg12559939 chr2:27858050 GPN1 0.4 6.32 0.33 8.49e-10 Oral cavity cancer; LUSC cis rs453301 0.624 rs2915251 chr8:8867411 G/C cg06636001 chr8:8085503 FLJ10661 0.63 9.66 0.47 1.22e-19 Joint mobility (Beighton score); LUSC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg15445000 chr17:37608096 MED1 0.39 6.58 0.34 1.86e-10 Glomerular filtration rate (creatinine); LUSC cis rs28735056 0.591 rs2277724 chr18:77694294 C/A cg20368463 chr18:77673604 PQLC1 -0.72 -11.43 -0.53 8.93e-26 Schizophrenia; LUSC cis rs7539542 0.516 rs10732291 chr1:202891168 G/A cg19681188 chr1:202830198 LOC148709 0.41 6.12 0.32 2.64e-9 Mean platelet volume; LUSC cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg24562669 chr7:97807699 LMTK2 0.45 8.09 0.4 1.1e-14 Breast cancer; LUSC cis rs1775715 0.737 rs2799031 chr10:32173168 C/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.86 0.4 5.38e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg08736216 chr1:53307985 ZYG11A -0.3 -6.12 -0.32 2.57e-9 Monocyte count; LUSC cis rs644799 0.509 rs580181 chr11:95643040 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.57 8.71 0.43 1.45e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.27 0.37 2.54e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12756686 chr19:29218302 NA 0.68 9.28 0.45 2.12e-18 Methadone dose in opioid dependence; LUSC cis rs11958404 0.932 rs12514557 chr5:157418954 T/C cg05962755 chr5:157440814 NA 0.51 6.21 0.32 1.58e-9 IgG glycosylation; LUSC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg04398451 chr17:18023971 MYO15A -0.48 -7.71 -0.39 1.44e-13 Total body bone mineral density; LUSC cis rs7577851 0.715 rs67340771 chr2:69615794 G/C cg10773587 chr2:69614142 GFPT1 0.58 6.43 0.33 4.53e-10 Parkinson's disease (age of onset); LUSC cis rs11023332 0.832 rs10832289 chr11:14669496 A/T cg19336497 chr11:14380999 RRAS2 0.36 7.05 0.36 1.04e-11 Adiponectin levels;Vitamin D levels; LUSC cis rs7089973 0.604 rs3758603 chr10:116605368 T/C cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3772130 0.564 rs28620947 chr3:121585631 G/A cg20356878 chr3:121714668 ILDR1 0.61 9.89 0.48 2.07e-20 Cognitive performance; LUSC cis rs7605827 0.930 rs3755129 chr2:15523549 T/C cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg09904177 chr6:26538194 HMGN4 -0.5 -5.95 -0.31 6.62e-9 Intelligence (multi-trait analysis); LUSC cis rs9815354 1.000 rs1994157 chr3:41897482 G/A cg03022575 chr3:42003672 ULK4 0.63 6.85 0.35 3.49e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs208515 0.525 rs10455593 chr6:66691341 C/T cg07460842 chr6:66804631 NA 1.06 14.42 0.62 5.65e-37 Exhaled nitric oxide levels; LUSC cis rs4919087 1.000 rs11189122 chr10:99072595 G/A cg25902810 chr10:99078978 FRAT1 0.48 7.16 0.36 5.23e-12 Monocyte count; LUSC cis rs1018836 0.851 rs7004287 chr8:91620842 G/C cg16814680 chr8:91681699 NA -0.79 -13.33 -0.59 8.69e-33 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7264396 0.943 rs224395 chr20:34109427 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.46 -0.33 3.72e-10 Total cholesterol levels; LUSC cis rs3931020 0.688 rs455032 chr1:75196488 C/T cg21535942 chr1:75199100 CRYZ;TYW3 -0.46 -5.93 -0.31 7.75e-9 Resistin levels; LUSC cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg23711669 chr6:146136114 FBXO30 0.77 13.91 0.61 5.36e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs1957429 0.808 rs8009510 chr14:65351338 T/G cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11890956 chr21:40555474 PSMG1 -1.03 -20.68 -0.75 9.41e-62 Cognitive function; LUSC cis rs2204008 0.571 rs7970136 chr12:38531951 G/C cg13010199 chr12:38710504 ALG10B -0.43 -6.52 -0.34 2.66e-10 Bladder cancer; LUSC cis rs2952156 0.959 rs1495101 chr17:37832103 C/A cg20243544 chr17:37824526 PNMT 0.49 6.88 0.35 2.98e-11 Asthma; LUSC cis rs4820294 0.669 rs7287358 chr22:38054403 A/G cg21798802 chr22:38057573 PDXP 0.32 6.64 0.34 1.29e-10 Fat distribution (HIV); LUSC cis rs11229555 0.574 rs72919749 chr11:58323467 T/C cg15696309 chr11:58395628 NA -0.69 -7.23 -0.37 3.32e-12 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6430585 0.528 rs16832440 chr2:136754183 G/A cg07169764 chr2:136633963 MCM6 1.13 17.53 0.69 2.98e-49 Corneal structure; LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.94e-10 Menopause (age at onset); LUSC cis rs6430585 0.583 rs730005 chr2:136582694 T/C cg07169764 chr2:136633963 MCM6 1.19 18.2 0.71 6.36e-52 Corneal structure; LUSC trans rs7044246 0.924 rs9411424 chr9:134864382 C/T cg03562770 chr12:39538604 NA -0.37 -6.21 -0.32 1.54e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs2197308 0.610 rs10880837 chr12:37864924 C/T cg06521331 chr12:34319734 NA -0.4 -6.23 -0.32 1.37e-9 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23375948 chr7:2105870 MAD1L1 0.48 6.18 0.32 1.89e-9 Bipolar disorder and schizophrenia; LUSC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.62e-10 Tonsillectomy; LUSC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg14829155 chr15:31115871 NA -0.58 -7.79 -0.39 8.28e-14 Huntington's disease progression; LUSC cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.91e-16 Menopause (age at onset); LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.9 0.44 3.49e-17 Prudent dietary pattern; LUSC cis rs3782089 0.793 rs34789990 chr11:65252477 G/T cg00206168 chr11:65308501 LTBP3 1.28 8.47 0.42 7.99e-16 Height; LUSC cis rs6503863 1 rs6503863 chr17:56517034 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.48 7.54 0.38 4.54e-13 Intelligence (multi-trait analysis); LUSC cis rs752010 0.902 rs60743712 chr1:42076629 G/A cg06885757 chr1:42089581 HIVEP3 0.47 9.64 0.47 1.41e-19 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs7605827 0.897 rs10166429 chr2:15514472 A/C cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.71e-17 Educational attainment (years of education); LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.48 5.72 0.3 2.31e-8 Renal function-related traits (BUN); LUSC cis rs10193935 1.000 rs10210866 chr2:42387879 A/G cg27598129 chr2:42591480 NA -0.57 -7.97 -0.4 2.56e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 12.73 0.57 1.5e-30 Platelet count; LUSC cis rs7605827 0.930 rs11679632 chr2:15605659 G/A cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg15423357 chr2:25149977 NA 0.4 7.83 0.39 6.45e-14 Body mass index; LUSC cis rs360798 0.532 rs360799 chr2:62953166 G/A cg17519650 chr2:63277830 OTX1 -0.52 -7.39 -0.38 1.16e-12 Coronary artery disease; LUSC trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg03929089 chr4:120376271 NA -0.8 -11.73 -0.54 7.43e-27 Coronary artery disease; LUSC cis rs2637266 0.935 rs2579728 chr10:78395598 A/G cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.95e-13 Pulmonary function; LUSC cis rs7980687 0.657 rs10744151 chr12:123723735 G/C cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.74 -0.35 7.07e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs10193935 0.786 rs13399052 chr2:42385151 G/A cg27598129 chr2:42591480 NA -0.57 -7.97 -0.4 2.56e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 0.534 rs12831685 chr12:34038392 C/T cg26384229 chr12:38710491 ALG10B 0.69 10.81 0.51 1.51e-23 Morning vs. evening chronotype; LUSC cis rs7072216 0.881 rs2274247 chr10:100150148 G/C cg26618903 chr10:100175079 PYROXD2 -0.29 -5.68 -0.3 2.88e-8 Metabolite levels; LUSC cis rs2439831 1.000 rs2444029 chr15:43737484 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.98 11.27 0.52 3.59e-25 Lung cancer in ever smokers; LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg05025164 chr4:1340916 KIAA1530 0.41 6.12 0.32 2.59e-9 Obesity-related traits; LUSC cis rs950776 0.518 rs3813571 chr15:78832792 G/T cg06917634 chr15:78832804 PSMA4 0.83 15.08 0.64 1.46e-39 Sudden cardiac arrest; LUSC cis rs7084921 0.608 rs11596211 chr10:101840119 T/A cg02250046 chr10:101825185 CPN1 -0.33 -5.98 -0.31 5.63e-9 Bone mineral density; LUSC cis rs1570884 0.516 rs9316463 chr13:50176844 G/A cg08779649 chr13:50194554 NA 0.41 6.92 0.35 2.27e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg07274523 chr3:49395745 GPX1 0.68 10.47 0.5 2.28e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg24531977 chr5:56204891 C5orf35 -0.55 -8.12 -0.41 9.25e-15 Breast cancer;Breast cancer (early onset); LUSC cis rs12681288 0.550 rs58295701 chr8:962136 T/C cg04851639 chr8:1020857 NA -0.4 -8.05 -0.4 1.45e-14 Schizophrenia; LUSC cis rs2970818 0.665 rs11063169 chr12:4573791 T/G cg11146114 chr12:4671731 NA -0.64 -6.25 -0.32 1.24e-9 Phosphorus levels; LUSC cis rs7829975 0.846 rs1879957 chr8:8544808 T/C cg18904891 chr8:8559673 CLDN23 -0.38 -5.87 -0.31 1.06e-8 Mood instability; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04841346 chr1:145096723 SEC22B 0.49 7.38 0.37 1.25e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10193935 0.901 rs6733464 chr2:42563597 A/G cg27598129 chr2:42591480 NA -0.61 -8.26 -0.41 3.47e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.78 10.03 0.48 7.15e-21 Gut microbiome composition (summer); LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18099408 chr3:52552593 STAB1 -0.39 -6.86 -0.35 3.41e-11 Bipolar disorder; LUSC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg05776053 chr2:74358815 NA 0.48 7.69 0.39 1.7e-13 Gestational age at birth (maternal effect); LUSC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg05855489 chr10:104503620 C10orf26 -0.62 -8.09 -0.4 1.15e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg06221963 chr1:154839813 KCNN3 -0.64 -15.08 -0.64 1.54e-39 Prostate cancer; LUSC cis rs1014246 0.848 rs2420330 chr10:118457481 C/T cg14919929 chr10:118506882 NA 0.43 6.84 0.35 3.68e-11 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs793571 0.590 rs673813 chr15:59077171 A/T cg05156742 chr15:59063176 FAM63B 0.55 8.46 0.42 8.42e-16 Schizophrenia; LUSC cis rs6964587 0.626 rs6972945 chr7:91549576 C/G cg17063962 chr7:91808500 NA -0.56 -9.22 -0.45 3.33e-18 Breast cancer; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg09315468 chr8:38089562 DDHD2 0.39 5.98 0.31 5.66e-9 Schizophrenia; LUSC cis rs7178572 0.568 rs10152181 chr15:77678346 A/G cg22256960 chr15:77711686 NA -0.5 -7.92 -0.4 3.57e-14 Type 2 diabetes; LUSC trans rs11098499 0.780 rs12504773 chr4:120562149 G/C cg25214090 chr10:38739885 LOC399744 0.54 7.89 0.4 4.22e-14 Corneal astigmatism; LUSC cis rs9902453 0.967 rs9913074 chr17:28481199 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.5 7.63 0.39 2.52e-13 Coffee consumption (cups per day); LUSC trans rs11039798 0.778 rs7944523 chr11:48911019 G/A cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg00071950 chr4:10020882 SLC2A9 -0.49 -8.17 -0.41 6.57e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2267137 0.903 rs5752903 chr22:29769306 G/T cg07256473 chr22:29710276 RASL10A 0.38 7.49 0.38 6.37e-13 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs9650315 0.929 rs57626491 chr8:57170336 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs6964587 0.967 rs12531966 chr7:91765840 A/G cg17063962 chr7:91808500 NA 0.57 8.8 0.43 7.52e-17 Breast cancer; LUSC trans rs28588043 0.550 rs9426921 chr1:170951864 C/A cg07135042 chr19:56905152 ZNF582 -0.61 -6.16 -0.32 2.08e-9 Number of children (6+ vs. 0 or 1); LUSC cis rs13088318 0.504 rs9828111 chr3:101197777 C/T cg12386194 chr3:101231763 SENP7 0.38 5.77 0.3 1.78e-8 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.83 0.6 1.04e-34 Platelet count; LUSC cis rs68092024 0.731 rs793479 chr3:99488232 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -7.02 -0.36 1.28e-11 Cleft lip with or without cleft palate; LUSC trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg15704280 chr7:45808275 SEPT13 0.93 13.51 0.59 1.78e-33 Height; LUSC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg05234568 chr11:5960015 NA -0.63 -9.86 -0.47 2.75e-20 DNA methylation (variation); LUSC cis rs7189233 0.955 rs11540358 chr16:53503943 C/G cg09728985 chr16:53543985 NA -0.34 -6.07 -0.32 3.5e-9 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg17968037 chr7:100024898 ZCWPW1 -0.41 -5.83 -0.3 1.28e-8 Platelet count; LUSC cis rs4148883 0.675 rs28762430 chr4:100119257 C/A cg12011299 chr4:100065546 ADH4 0.47 7.65 0.39 2.19e-13 Alcohol dependence; LUSC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg02711726 chr17:80685570 FN3KRP -0.41 -6.17 -0.32 1.96e-9 Glycated hemoglobin levels; LUSC trans rs9929218 0.551 rs3785135 chr16:68728976 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -1.05 -23.79 -0.79 7e-74 Colorectal cancer; LUSC cis rs7107174 0.688 rs11237490 chr11:78135229 C/T cg02023728 chr11:77925099 USP35 0.42 6.46 0.33 3.75e-10 Testicular germ cell tumor; LUSC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg04733989 chr22:42467013 NAGA 0.54 8.42 0.42 1.15e-15 Schizophrenia; LUSC cis rs11690935 0.843 rs9784070 chr2:172785007 C/T cg13550731 chr2:172543902 DYNC1I2 -0.79 -12.19 -0.55 1.55e-28 Schizophrenia; LUSC cis rs7824557 0.767 rs6991606 chr8:11176159 G/A cg21775007 chr8:11205619 TDH 0.74 12.22 0.56 1.25e-28 Retinal vascular caliber; LUSC cis rs6087990 0.806 rs2424918 chr20:31382770 C/T cg13636640 chr20:31349939 DNMT3B 0.91 19.16 0.72 9.72e-56 Ulcerative colitis; LUSC cis rs9796 0.558 rs4445868 chr15:41531991 C/T cg18705301 chr15:41695430 NDUFAF1 -0.49 -8.54 -0.42 4.87e-16 Menopause (age at onset); LUSC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg18230493 chr5:56204884 C5orf35 -0.55 -8.79 -0.43 8.22e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg24642439 chr20:33292090 TP53INP2 0.75 11.95 0.55 1.22e-27 Coronary artery disease; LUSC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg04414720 chr1:150670196 GOLPH3L -0.48 -7.15 -0.36 5.41e-12 Urate levels; LUSC cis rs7937682 0.883 rs1789351 chr11:111456436 T/A cg11344533 chr11:111475393 SIK2 -0.46 -6.35 -0.33 6.87e-10 Primary sclerosing cholangitis; LUSC cis rs9486715 0.867 rs3849199 chr6:97049191 T/C cg06623918 chr6:96969491 KIAA0776 -0.95 -18.42 -0.71 8.69e-53 Headache; LUSC trans rs1728785 1.000 rs1645923 chr16:68581051 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs1799949 0.965 rs799912 chr17:41257134 T/C cg05368731 chr17:41323189 NBR1 0.81 13.21 0.59 2.46e-32 Menopause (age at onset); LUSC cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.46 -0.42 8.4e-16 Chronic sinus infection; LUSC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.63 13.88 0.6 6.84e-35 Hemoglobin concentration; LUSC cis rs8141529 0.778 rs7287806 chr22:29213011 G/A cg02153584 chr22:29168773 CCDC117 0.66 10.32 0.49 7.36e-22 Lymphocyte counts; LUSC cis rs10743315 0.557 rs77344887 chr12:19312751 C/T cg02471346 chr12:19282374 PLEKHA5 0.8 6.4 0.33 5.14e-10 Gut microbiota (bacterial taxa); LUSC cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg14993813 chr1:46806288 NSUN4 -0.52 -7.31 -0.37 1.96e-12 Menopause (age at onset); LUSC cis rs11264799 0.501 rs849827 chr1:157545231 G/T cg18268488 chr1:157545234 FCRL4 0.39 7.69 0.39 1.62e-13 IgA nephropathy; LUSC cis rs4631830 0.900 rs10763534 chr10:51534920 C/T cg20129853 chr10:51489980 NA -0.35 -7.17 -0.37 4.88e-12 Prostate-specific antigen levels; LUSC cis rs8114671 0.562 rs2223881 chr20:33506463 A/C cg24642439 chr20:33292090 TP53INP2 0.45 6.48 0.33 3.38e-10 Height; LUSC cis rs6840360 0.593 rs1429558 chr4:152685406 A/T cg22705602 chr4:152727874 NA -0.34 -7.57 -0.38 3.75e-13 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg27170947 chr2:26402098 FAM59B -0.63 -9.33 -0.45 1.53e-18 Gut microbiome composition (summer); LUSC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg00343986 chr7:65444356 GUSB -0.43 -6.26 -0.32 1.19e-9 Aortic root size; LUSC cis rs2658782 0.724 rs1869914 chr11:93112492 C/G cg15737290 chr11:93063684 CCDC67 0.63 7.65 0.39 2.2e-13 Pulmonary function decline; LUSC cis rs854765 0.583 rs7503334 chr17:17779458 C/T cg16928487 chr17:17741425 SREBF1 0.46 9.03 0.44 1.4e-17 Total body bone mineral density; LUSC cis rs1577917 1.000 rs12199516 chr6:86726221 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.68 -0.34 1.01e-10 Response to antipsychotic treatment; LUSC cis rs6964587 0.755 rs13229505 chr7:91444679 G/T cg22709100 chr7:91322751 NA 0.47 6.93 0.35 2.21e-11 Breast cancer; LUSC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg14552801 chr7:65878734 NA 0.45 6.39 0.33 5.71e-10 Aortic root size; LUSC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg24733560 chr20:60626293 TAF4 0.36 5.89 0.31 9.44e-9 Body mass index; LUSC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg18876405 chr7:65276391 NA 0.7 12.23 0.56 1.17e-28 Aortic root size; LUSC trans rs236907 0.859 rs3891278 chr1:171756248 A/C cg13482142 chr2:234261155 NA 0.48 5.96 0.31 6.35e-9 Mean platelet volume; LUSC cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.11 0.32 2.72e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1728785 0.901 rs1170438 chr16:68608256 T/C cg02972257 chr16:68554789 NA -0.5 -6.18 -0.32 1.91e-9 Ulcerative colitis; LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.71 0.47 8.56e-20 Bipolar disorder; LUSC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03517284 chr6:25882590 NA -0.4 -6.81 -0.35 4.47e-11 Intelligence (multi-trait analysis); LUSC trans rs637571 0.780 rs677029 chr11:65683531 A/G cg17712092 chr4:129076599 LARP1B 1.02 18.06 0.7 2.44e-51 Eosinophil percentage of white cells; LUSC trans rs9910292 0.591 rs12944197 chr17:31353532 G/A cg03789507 chr8:136667083 NA 0.48 6.13 0.32 2.44e-9 Mosquito bite size; LUSC cis rs3760982 0.585 rs61013802 chr19:44292142 A/T cg11993925 chr19:44307056 LYPD5 0.35 7.57 0.38 3.76e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs6495122 0.630 rs12912343 chr15:75251041 C/G cg10253484 chr15:75165896 SCAMP2 -0.49 -6.91 -0.35 2.4e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg06363034 chr20:62225388 GMEB2 -0.45 -7.71 -0.39 1.47e-13 Glioblastoma; LUSC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs3736594 0.527 rs62141279 chr2:27771415 C/T cg27432699 chr2:27873401 GPN1 0.69 9.11 0.45 7.55e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2717559 0.542 rs34147336 chr8:143884869 A/G cg07661805 chr8:143867942 LY6D -0.26 -6.01 -0.31 4.78e-9 Urinary tract infection frequency; LUSC cis rs12291225 0.679 rs11023170 chr11:14294909 A/G cg19336497 chr11:14380999 RRAS2 -0.57 -11.78 -0.54 5.12e-27 Sense of smell; LUSC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg02782426 chr3:40428986 ENTPD3 0.43 7.93 0.4 3.31e-14 Renal cell carcinoma; LUSC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg03433033 chr1:76189801 ACADM -0.72 -9.53 -0.46 3.32e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg09184832 chr6:79620586 NA -0.42 -6.79 -0.35 5.28e-11 Intelligence (multi-trait analysis); LUSC cis rs240768 1.000 rs240165 chr6:101043226 T/G cg12253828 chr6:101329408 ASCC3 0.84 5.74 0.3 2.11e-8 Economic and political preferences (immigration/crime); LUSC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg11941060 chr3:133502564 NA 0.38 5.96 0.31 6.37e-9 Alcohol consumption (transferrin glycosylation); LUSC cis rs6546550 0.901 rs4144081 chr2:70155482 G/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.17e-12 Prevalent atrial fibrillation; LUSC cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg18850127 chr7:39170497 POU6F2 0.61 9.34 0.46 1.4e-18 IgG glycosylation; LUSC cis rs3733418 0.929 rs13120990 chr4:165905118 A/G cg11630554 chr4:165878136 TRIM61;C4orf39 -0.51 -5.84 -0.3 1.25e-8 Obesity-related traits; LUSC cis rs8062405 1.000 rs2008514 chr16:28825605 A/G cg09754948 chr16:28834200 ATXN2L -0.44 -6.42 -0.33 4.58e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4595586 0.545 rs12810822 chr12:39391807 T/A cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC trans rs11088226 0.681 rs16989507 chr21:33939509 T/G cg09050820 chr6:167586206 TCP10L2 0.73 9.47 0.46 5.31e-19 Gastritis; LUSC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg18190219 chr22:46762943 CELSR1 -0.49 -6.08 -0.32 3.2e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs595982 0.559 rs117227130 chr19:49367959 A/G cg15549821 chr19:49342101 PLEKHA4 -0.59 -8.04 -0.4 1.6e-14 Red cell distribution width; LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg01879757 chr17:41196368 BRCA1 -0.46 -7.0 -0.36 1.42e-11 Menopause (age at onset); LUSC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.54 7.51 0.38 5.5e-13 Multiple sclerosis; LUSC trans rs9747201 0.925 rs8072670 chr17:80159566 T/C cg07393940 chr7:158741817 NA 0.52 8.6 0.43 3.15e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg13319975 chr6:146136371 FBXO30 -0.68 -10.52 -0.5 1.56e-22 Lobe attachment (rater-scored or self-reported); LUSC trans rs4843747 0.519 rs12599755 chr16:88107006 A/G cg26811252 chr16:29126840 RRN3P2 0.61 9.64 0.47 1.46e-19 Menopause (age at onset); LUSC trans rs7939886 0.920 rs11231885 chr11:55804022 T/A cg15704280 chr7:45808275 SEPT13 0.8 6.88 0.35 3.04e-11 Myopia (pathological); LUSC cis rs9905704 0.918 rs302852 chr17:56685214 C/T cg12560992 chr17:57184187 TRIM37 0.55 7.87 0.4 4.98e-14 Testicular germ cell tumor; LUSC cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg21535247 chr6:8435926 SLC35B3 0.59 9.28 0.45 2.14e-18 Motion sickness; LUSC cis rs9325144 0.555 rs4882284 chr12:38710459 C/T cg26384229 chr12:38710491 ALG10B -0.63 -9.97 -0.48 1.18e-20 Morning vs. evening chronotype; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg00106254 chr7:1943704 MAD1L1 -0.39 -5.81 -0.3 1.45e-8 Bipolar disorder and schizophrenia; LUSC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -7.69 -0.39 1.69e-13 Hemoglobin concentration; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg22907277 chr7:1156413 C7orf50 0.63 9.78 0.47 4.82e-20 Longevity;Endometriosis; LUSC cis rs561341 1.000 rs8070262 chr17:30262467 A/G cg00745463 chr17:30367425 LRRC37B -0.67 -7.89 -0.4 4.47e-14 Hip circumference adjusted for BMI; LUSC trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg11887960 chr12:57824829 NA 0.58 7.05 0.36 1.05e-11 Lung disease severity in cystic fibrosis; LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs4969178 0.965 rs12450528 chr17:76395753 G/A cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg16606324 chr3:10149918 C3orf24 0.58 8.23 0.41 4.27e-15 Alzheimer's disease; LUSC cis rs734999 0.545 rs10797441 chr1:2551660 T/G cg18854424 chr1:2615690 NA 0.5 10.05 0.48 6.38e-21 Ulcerative colitis; LUSC trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.23e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs4319547 0.586 rs7956480 chr12:122817507 A/G cg23029597 chr12:123009494 RSRC2 -0.74 -9.26 -0.45 2.62e-18 Body mass index; LUSC cis rs2742234 0.910 rs2505505 chr10:43648221 G/T cg02780029 chr10:43622663 RET -0.36 -7.11 -0.36 7.03e-12 Hirschsprung disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05164514 chr4:148605397 PRMT10 -0.39 -5.96 -0.31 6.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs72674100 1.000 rs6849450 chr4:97986017 C/A cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg13298116 chr11:62369859 EML3;MTA2 0.59 9.61 0.47 1.78e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9354352 0.818 rs9453548 chr6:66691885 T/C cg07460842 chr6:66804631 NA -0.6 -8.65 -0.43 2.21e-16 Initial pursuit acceleration in psychotic disorders; LUSC cis rs7582180 0.614 rs1530031 chr2:101009326 T/C cg12002119 chr2:101014098 CHST10 0.38 6.38 0.33 6.04e-10 Intelligence (multi-trait analysis); LUSC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg14298792 chr15:30685198 CHRFAM7A -0.47 -6.04 -0.31 4.08e-9 Huntington's disease progression; LUSC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg04369109 chr6:150039330 LATS1 -0.54 -8.03 -0.4 1.7e-14 Lung cancer; LUSC cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg05347473 chr6:146136440 FBXO30 -0.6 -10.67 -0.5 4.62e-23 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs34997501 chr12:34549828 C/G cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.15e-14 Glomerular filtration rate (creatinine); LUSC cis rs77372450 0.636 rs77291311 chr5:157018650 T/C cg25387487 chr5:157003181 ADAM19 -0.5 -5.83 -0.3 1.28e-8 Bipolar disorder (body mass index interaction); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg19388017 chr19:15285100 NOTCH3 -0.4 -6.12 -0.32 2.56e-9 Asthma; LUSC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg18404041 chr3:52824283 ITIH1 -0.37 -6.42 -0.33 4.62e-10 Electroencephalogram traits; LUSC cis rs10193935 0.901 rs17029344 chr2:42444287 T/C cg27598129 chr2:42591480 NA -0.63 -8.38 -0.42 1.44e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs2074585 0.708 rs2589939 chr15:90930875 C/T cg22089800 chr15:90895588 ZNF774 0.66 10.32 0.49 7.21e-22 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg08859206 chr1:53392774 SCP2 -0.6 -11.28 -0.53 3.11e-25 Monocyte count; LUSC cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.11e-40 Drug-induced liver injury (flucloxacillin); LUSC trans rs3960554 0.673 rs57358338 chr7:75732923 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 9.74 0.47 6.94e-20 Eotaxin levels; LUSC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg22800045 chr5:56110881 MAP3K1 0.77 9.42 0.46 7.46e-19 Initial pursuit acceleration; LUSC cis rs11098499 0.866 rs3756156 chr4:120524841 G/A cg24375607 chr4:120327624 NA 0.72 11.1 0.52 1.45e-24 Corneal astigmatism; LUSC cis rs4805272 0.512 rs12373558 chr19:29337692 A/G cg03161606 chr19:29218774 NA 0.48 5.88 0.31 9.72e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs4363385 0.747 rs6689609 chr1:152967588 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.64 -0.39 2.28e-13 Inflammatory skin disease; LUSC cis rs1950626 0.833 rs12891189 chr14:101415523 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.42 7.46 0.38 7.73e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs9462027 0.651 rs9469884 chr6:34758703 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.82 -0.3 1.38e-8 Systemic lupus erythematosus; LUSC cis rs2439831 1.000 rs2467426 chr15:43989518 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.75 7.24 0.37 3.13e-12 Lung cancer in ever smokers; LUSC cis rs61931739 0.890 rs694706 chr12:34135323 T/C cg06521331 chr12:34319734 NA -0.37 -6.32 -0.33 8.26e-10 Morning vs. evening chronotype; LUSC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg07936489 chr17:37558343 FBXL20 0.72 9.96 0.48 1.28e-20 Glomerular filtration rate (creatinine); LUSC cis rs2439831 1.000 rs2253708 chr15:43797273 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.15 0.52 9.43e-25 Lung cancer in ever smokers; LUSC cis rs7759001 0.857 rs3734574 chr6:27371193 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC cis rs12421382 0.659 rs1439518 chr11:109382921 T/G cg16359550 chr11:109292809 C11orf87 0.37 6.38 0.33 5.9e-10 Schizophrenia; LUSC cis rs6665290 0.901 rs12410103 chr1:227197408 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -39.91 -0.91 3.76e-129 Myeloid white cell count; LUSC cis rs7246657 0.524 rs28542490 chr19:37456584 C/A cg23950597 chr19:37808831 NA -0.52 -5.82 -0.3 1.42e-8 Coronary artery calcification; LUSC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg22467129 chr15:76604101 ETFA -0.42 -6.64 -0.34 1.27e-10 Blood metabolite levels; LUSC cis rs950169 0.887 rs12903946 chr15:84954430 T/C cg12863693 chr15:85201151 NMB 0.36 7.06 0.36 9.44e-12 Schizophrenia; LUSC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg03929089 chr4:120376271 NA -0.94 -15.02 -0.63 2.46e-39 Coronary artery disease; LUSC cis rs9790314 0.560 rs4856701 chr3:161044106 G/T cg03342759 chr3:160939853 NMD3 -0.42 -6.23 -0.32 1.43e-9 Morning vs. evening chronotype; LUSC cis rs12760731 0.565 rs6701832 chr1:178156775 A/G cg00404053 chr1:178313656 RASAL2 0.66 6.8 0.35 4.85e-11 Obesity-related traits; LUSC cis rs7577851 0.762 rs41285955 chr2:69709079 A/T cg10773587 chr2:69614142 GFPT1 0.48 5.67 0.3 3.03e-8 Parkinson's disease (age of onset); LUSC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg05535760 chr7:792225 HEATR2 -0.78 -7.87 -0.4 4.83e-14 Cerebrospinal P-tau181p levels; LUSC cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs6762 0.550 rs8672 chr11:838634 C/G cg03116740 chr11:841335 TSPAN4;POLR2L -0.41 -6.53 -0.34 2.46e-10 Mean platelet volume; LUSC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg10523679 chr1:76189770 ACADM 0.89 15.49 0.65 3.73e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 10.81 0.51 1.45e-23 Alzheimer's disease; LUSC cis rs7617773 0.817 rs6796490 chr3:48237104 A/C cg11946769 chr3:48343235 NME6 0.71 11.35 0.53 1.84e-25 Coronary artery disease; LUSC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg13395646 chr4:1353034 KIAA1530 -0.6 -9.39 -0.46 9.66e-19 Longevity; LUSC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg07701084 chr6:150067640 NUP43 0.53 7.85 0.39 5.88e-14 Lung cancer; LUSC cis rs5758511 0.573 rs2267439 chr22:42237769 C/T cg03131358 chr22:42195972 CCDC134 -0.33 -5.75 -0.3 2.01e-8 Birth weight; LUSC cis rs7582720 1.000 rs72932777 chr2:203689914 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 7.98 0.4 2.35e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs11864453 0.713 rs12708927 chr16:72126165 C/T cg01557791 chr16:72042693 DHODH -0.52 -7.54 -0.38 4.42e-13 Fibrinogen levels; LUSC cis rs9549367 0.789 rs7999579 chr13:113879357 T/C cg18105134 chr13:113819100 PROZ -0.67 -9.55 -0.46 2.88e-19 Platelet distribution width; LUSC cis rs2625529 0.938 rs4777464 chr15:72131763 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.53 -0.38 4.92e-13 Red blood cell count; LUSC cis rs5769707 0.632 rs135876 chr22:50013573 A/G cg20744362 chr22:50050164 C22orf34 0.39 7.16 0.36 5.13e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11190604 1.000 rs7090431 chr10:102261753 A/G cg23241863 chr10:102295624 HIF1AN 0.49 6.12 0.32 2.64e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2295359 1.000 rs736197 chr1:67607135 G/T cg03340356 chr1:67600835 NA 0.44 7.03 0.36 1.18e-11 Psoriasis; LUSC cis rs6754311 0.551 rs10928545 chr2:136501840 A/G cg07169764 chr2:136633963 MCM6 -0.74 -9.84 -0.47 3.17e-20 Mosquito bite size; LUSC cis rs2762353 0.935 rs1183200 chr6:25818646 G/C cg03264133 chr6:25882463 NA -0.44 -7.74 -0.39 1.16e-13 Blood metabolite levels; LUSC cis rs2625529 1.000 rs2625529 chr15:72118777 C/G cg16672083 chr15:72433130 SENP8 0.39 6.07 0.31 3.56e-9 Red blood cell count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26039424 chr1:46154040 TMEM69 -0.44 -6.66 -0.34 1.12e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2274273 0.662 rs2094436 chr14:55661495 C/G cg04306507 chr14:55594613 LGALS3 0.48 9.67 0.47 1.2e-19 Protein biomarker; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12197573 chr18:14470687 NA -0.29 -6.64 -0.34 1.27e-10 Electrocardiographic conduction measures; LUSC cis rs4812048 1.000 rs6070697 chr20:57599402 G/A cg14073986 chr20:57617431 SLMO2 0.62 6.81 0.35 4.54e-11 Mean platelet volume; LUSC cis rs8017423 0.967 rs2277517 chr14:90722778 G/A cg04374321 chr14:90722782 PSMC1 0.75 12.08 0.55 4e-28 Mortality in heart failure; LUSC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg17252645 chr8:143867129 LY6D -0.37 -6.43 -0.33 4.42e-10 Urinary tract infection frequency; LUSC trans rs7939886 0.920 rs11227428 chr11:55941972 C/G cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC cis rs4622329 0.615 rs7306175 chr12:102294618 G/T cg23541617 chr12:102225335 GNPTAB 0.28 6.35 0.33 7.16e-10 Systemic lupus erythematosus; LUSC cis rs10979 0.597 rs9390118 chr6:143907610 A/G cg25407410 chr6:143891975 LOC285740 -0.65 -8.19 -0.41 5.6e-15 Hypospadias; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19853194 chr18:9913725 VAPA 0.42 6.49 0.33 3.16e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg02117656 chr17:79614917 TSPAN10 -0.31 -5.69 -0.3 2.75e-8 Eye color traits; LUSC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg11060661 chr22:24314208 DDT;DDTL 0.48 7.89 0.4 4.42e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg03433033 chr1:76189801 ACADM 0.8 13.32 0.59 8.93e-33 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4953404 0.613 rs897532 chr2:46893225 G/A cg09399716 chr2:46890238 NA -0.32 -7.17 -0.37 4.93e-12 Pulse pressure (alcohol consumption interaction); LUSC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg04362960 chr10:104952993 NT5C2 0.59 9.3 0.45 1.91e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11122272 0.701 rs2491402 chr1:231494338 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.9 0.48 1.99e-20 Hemoglobin concentration; LUSC cis rs3744061 0.505 rs9915915 chr17:74652274 A/G cg27546012 chr17:74684504 MXRA7 -0.38 -6.6 -0.34 1.63e-10 Retinal arteriolar caliber; LUSC cis rs7769051 1.000 rs9493444 chr6:133125320 C/G cg22852734 chr6:133119734 C6orf192 1.22 14.16 0.61 5.69e-36 Type 2 diabetes nephropathy; LUSC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg16434002 chr17:42200994 HDAC5 0.46 6.79 0.35 5.28e-11 Total body bone mineral density; LUSC cis rs7973719 0.865 rs12228393 chr12:7368182 A/G cg07052231 chr12:7363540 PEX5 -0.52 -9.1 -0.45 8.41e-18 IgG glycosylation; LUSC cis rs9815354 0.812 rs77732985 chr3:41945872 G/A cg03022575 chr3:42003672 ULK4 0.82 8.57 0.42 3.94e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg03233332 chr7:66118400 NA 0.4 5.89 0.31 9.29e-9 Aortic root size; LUSC cis rs13242816 1.000 rs35595472 chr7:116122306 G/A cg16553024 chr7:116138462 CAV2 -0.52 -5.68 -0.3 2.89e-8 P wave duration; LUSC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg16049864 chr8:95962084 TP53INP1 0.47 7.5 0.38 5.81e-13 Type 2 diabetes; LUSC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg12963246 chr6:28129442 ZNF389 -0.56 -8.07 -0.4 1.31e-14 Depression; LUSC cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg23158103 chr7:148848205 ZNF398 -0.47 -7.52 -0.38 5.05e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.17 0.52 7.73e-25 Prudent dietary pattern; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg21782813 chr7:2030301 MAD1L1 0.4 6.59 0.34 1.7e-10 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22307029 chr19:49891270 CCDC155 0.68 9.47 0.46 5.35e-19 Multiple sclerosis; LUSC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 13.28 0.59 1.37e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg05234568 chr11:5960015 NA -0.58 -9.54 -0.46 3.1400000000000002e-19 DNA methylation (variation); LUSC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg18357526 chr6:26021779 HIST1H4A -0.44 -6.89 -0.35 2.76e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.906 rs2270609 chr8:58194684 G/A cg08219700 chr8:58056026 NA 0.5 5.93 0.31 7.63e-9 Developmental language disorder (linguistic errors); LUSC cis rs7216064 1.000 rs62084213 chr17:65842016 A/G cg12091567 chr17:66097778 LOC651250 -0.75 -9.35 -0.46 1.27e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2463822 0.583 rs72919472 chr11:62040655 C/T cg06239285 chr11:62104954 ASRGL1 -0.66 -6.8 -0.35 4.87e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs983392 0.709 rs4492839 chr11:59986399 T/A cg02771260 chr11:59836817 MS4A3 -0.36 -5.93 -0.31 7.71e-9 Alzheimer's disease (late onset); LUSC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.52 -0.34 2.53e-10 High light scatter reticulocyte count; LUSC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg06212747 chr3:49208901 KLHDC8B 0.44 5.98 0.31 5.79e-9 Parkinson's disease; LUSC cis rs9811920 0.535 rs792835 chr3:99476295 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.31 -5.85 -0.31 1.15e-8 Axial length; LUSC cis rs34638657 0.732 rs7206093 chr16:82201884 G/A cg09439754 chr16:82129088 HSD17B2 -0.39 -6.45 -0.33 3.97e-10 Lung adenocarcinoma; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg01238044 chr22:24384105 GSTT1 -0.53 -7.69 -0.39 1.7e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg10057126 chr4:77819792 ANKRD56 0.5 7.6 0.38 3.03e-13 Emphysema distribution in smoking; LUSC cis rs7267979 0.966 rs2257705 chr20:25264664 T/C cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.56e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs970548 0.657 rs11239572 chr10:46088061 C/T cg14222797 chr10:16859974 RSU1 0.59 6.14 0.32 2.38e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs9326248 0.559 rs4938334 chr11:116931042 G/C cg20608306 chr11:116969690 SIK3 0.37 6.8 0.35 4.86e-11 Blood protein levels; LUSC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg04248312 chr19:17393744 ANKLE1 -1.03 -16.75 -0.68 3.86e-46 Systemic lupus erythematosus; LUSC cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.82 -0.39 7.15e-14 Neuroticism; LUSC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg04369109 chr6:150039330 LATS1 0.53 7.73 0.39 1.25e-13 Lung cancer; LUSC cis rs4680 0.737 rs6269 chr22:19949952 A/G cg23601416 chr22:19950040 COMT -0.45 -9.27 -0.45 2.39e-18 Blood metabolite levels; LUSC cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9303401 0.659 rs11079358 chr17:56920949 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.67 0.6 4.46e-34 Cognitive test performance; LUSC trans rs7495211 0.509 rs11247363 chr15:98623942 C/T cg08901157 chr15:56033728 PRTG 0.35 6.12 0.32 2.63e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs868036 0.609 rs3784707 chr15:68043878 A/C cg08079166 chr15:68083412 MAP2K5 0.46 7.87 0.4 4.85e-14 Restless legs syndrome; LUSC cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg01849466 chr14:104193079 ZFYVE21 -0.55 -8.63 -0.43 2.61e-16 Schizophrenia; LUSC cis rs61931739 0.517 rs4104182 chr12:34081343 G/A cg06521331 chr12:34319734 NA -0.47 -7.66 -0.39 2.06e-13 Morning vs. evening chronotype; LUSC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg16049864 chr8:95962084 TP53INP1 -0.63 -12.41 -0.56 2.49e-29 Type 2 diabetes; LUSC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg20607287 chr7:12443886 VWDE -0.61 -6.34 -0.33 7.27e-10 Coronary artery disease; LUSC cis rs7267979 0.932 rs6037125 chr20:25463382 G/A cg08601574 chr20:25228251 PYGB 0.42 6.33 0.33 7.89e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7192380 0.928 rs12933210 chr16:69742048 A/T cg00738113 chr16:70207722 CLEC18C 0.27 5.92 0.31 7.83e-9 Sjögren's syndrome; LUSC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg06022373 chr22:39101656 GTPBP1 0.84 14.0 0.61 2.38e-35 Menopause (age at onset); LUSC cis rs2439831 0.850 rs9944216 chr15:44160773 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.74 -6.54 -0.34 2.32e-10 Lung cancer in ever smokers; LUSC cis rs9393692 0.645 rs2179152 chr6:26325888 T/C cg13736514 chr6:26305472 NA -0.55 -10.66 -0.5 4.87e-23 Educational attainment; LUSC cis rs2073300 1.000 rs6106669 chr20:23460328 C/T cg09953122 chr20:23471693 CST8 -0.76 -7.01 -0.36 1.31e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7236492 0.748 rs11663658 chr18:77197555 T/C cg15644404 chr18:77186268 NFATC1 -0.68 -7.6 -0.38 2.97e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4423214 1.000 rs12419334 chr11:71139472 T/C cg05163923 chr11:71159392 DHCR7 0.66 9.82 0.47 3.7799999999999997e-20 Vitamin D levels; LUSC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg20476274 chr7:133979776 SLC35B4 0.88 16.9 0.68 1.01e-46 Mean platelet volume; LUSC cis rs57994353 0.568 rs3812581 chr9:139311471 C/T cg14019695 chr9:139328340 INPP5E 0.37 5.79 0.3 1.67e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; LUSC cis rs983392 0.649 rs7936120 chr11:60000574 T/A cg20284999 chr11:59952153 MS4A6A -0.36 -6.09 -0.32 3.14e-9 Alzheimer's disease (late onset); LUSC cis rs7843479 0.965 rs878872 chr8:21834567 A/G cg17168535 chr8:21777572 XPO7 0.67 10.21 0.49 1.71e-21 Mean corpuscular volume; LUSC cis rs6500602 0.963 rs7201012 chr16:4480682 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 6.24 0.32 1.33e-9 Schizophrenia; LUSC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.34e-12 Tonsillectomy; LUSC trans rs61931739 0.534 rs1852222 chr12:34008665 C/A cg26384229 chr12:38710491 ALG10B 0.69 10.73 0.51 2.8e-23 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09918929 chr12:92540332 BTG1 0.49 6.93 0.35 2.13e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12594515 1.000 rs8038320 chr15:45990267 G/C cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC cis rs4787491 0.729 rs7191849 chr16:30023157 T/C cg06326092 chr16:30034487 C16orf92 0.23 5.68 0.3 2.89e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.36 0.37 1.47e-12 Bipolar disorder; LUSC cis rs5769707 0.749 rs7286706 chr22:50058346 G/C cg08680598 chr22:49984980 NA -0.36 -6.52 -0.34 2.6200000000000003e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11031096 0.678 rs17284356 chr11:4189232 G/C cg18678763 chr11:4115507 RRM1 -0.41 -5.76 -0.3 1.96e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg24692254 chr21:30365293 RNF160 -0.82 -15.1 -0.64 1.19e-39 Dental caries; LUSC cis rs11148252 0.574 rs2038826 chr13:53280013 G/A cg00495681 chr13:53174319 NA 0.78 14.66 0.63 6.17e-38 Lewy body disease; LUSC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg09655341 chr17:79618100 PDE6G -0.28 -6.26 -0.32 1.18e-9 Eye color traits; LUSC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg04369109 chr6:150039330 LATS1 -0.58 -8.44 -0.42 9.96e-16 Lung cancer; LUSC cis rs4930103 0.602 rs170101 chr11:2008936 C/T cg06197492 chr11:2016605 H19 0.44 7.14 0.36 5.79e-12 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16263627 chr15:100339283 C15orf51 0.49 6.45 0.33 3.83e-10 Bipolar disorder and schizophrenia; LUSC trans rs867371 0.826 rs2047678 chr15:82498198 G/A cg18393722 chr15:85113863 UBE2QP1 -0.42 -6.11 -0.32 2.84e-9 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg11663144 chr21:46675770 NA -0.4 -7.16 -0.36 5.12e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7589342 0.536 rs10173137 chr2:106388049 A/C cg09152813 chr2:106391379 NCK2 -0.38 -6.24 -0.32 1.31e-9 Addiction; LUSC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23221052 chr5:179740743 GFPT2 -0.55 -8.8 -0.43 7.42e-17 Height; LUSC cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg22709100 chr7:91322751 NA 0.4 5.8 0.3 1.56e-8 Breast cancer; LUSC cis rs9303401 0.659 rs11079357 chr17:56902778 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.67 0.6 4.46e-34 Cognitive test performance; LUSC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg13393036 chr8:95962371 TP53INP1 -0.45 -9.39 -0.46 9.89e-19 Type 2 diabetes; LUSC cis rs7590720 0.851 rs13006614 chr2:216876204 C/T cg12620499 chr2:216877984 MREG 0.98 16.91 0.68 8.98e-47 Alcohol dependence; LUSC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg07701084 chr6:150067640 NUP43 0.54 8.08 0.4 1.17e-14 Lung cancer; LUSC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg16049864 chr8:95962084 TP53INP1 -0.73 -14.1 -0.61 9.54e-36 Type 2 diabetes; LUSC cis rs1801251 0.778 rs709933 chr2:233733144 G/A cg25237894 chr2:233734115 C2orf82 -0.35 -6.67 -0.34 1.09e-10 Coronary artery disease; LUSC cis rs193541 0.632 rs2910135 chr5:122229790 C/T cg19077854 chr5:122220652 SNX24 0.38 7.92 0.4 3.5e-14 Glucose homeostasis traits; LUSC trans rs6502050 0.799 rs6502078 chr17:80124364 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.71e-10 Life satisfaction; LUSC trans rs1925953 1.000 rs1925953 chr1:68848681 A/T cg15617548 chr2:171785815 GORASP2 -0.39 -6.12 -0.32 2.58e-9 Vertical cup-disc ratio; LUSC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg22709217 chr22:50311962 ALG12;CRELD2 0.8 10.5 0.5 1.74e-22 Schizophrenia; LUSC cis rs10193935 0.901 rs222488 chr2:42648570 T/G cg27598129 chr2:42591480 NA -0.6 -8.25 -0.41 3.7e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs921968 0.565 rs2272188 chr2:219612282 C/T cg02176678 chr2:219576539 TTLL4 0.57 10.06 0.48 5.77e-21 Mean corpuscular hemoglobin concentration; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg09006514 chr2:127800616 NA -0.34 -6.2 -0.32 1.62e-9 N-glycan levels; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg23034840 chr1:205782522 SLC41A1 0.61 8.66 0.43 2.05e-16 Menarche (age at onset); LUSC cis rs765787 0.556 rs10851422 chr15:45513738 T/C cg25801113 chr15:45476975 SHF -0.34 -6.71 -0.34 8.19e-11 Uric acid levels; LUSC cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg21724239 chr8:58056113 NA 0.59 7.2 0.37 4.05e-12 Developmental language disorder (linguistic errors); LUSC cis rs60843830 0.661 rs62116682 chr2:104618 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.44 6.62 0.34 1.43e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg00530320 chr1:46809349 NSUN4 0.55 8.49 0.42 6.7e-16 Menopause (age at onset); LUSC cis rs2070997 0.667 rs13287613 chr9:133715291 T/C cg11464064 chr9:133710261 ABL1 0.48 5.65 0.3 3.47e-8 Response to amphetamines; LUSC cis rs12148488 0.966 rs12899062 chr15:75347641 A/C cg14664628 chr15:75095509 CSK 0.42 6.02 0.31 4.53e-9 Caffeine consumption; LUSC cis rs2832191 0.716 rs8132085 chr21:30501389 G/T cg24692254 chr21:30365293 RNF160 -0.9 -17.62 -0.69 1.32e-49 Dental caries; LUSC cis rs7474896 0.583 rs10827818 chr10:38000856 T/C cg25427524 chr10:38739819 LOC399744 -0.49 -6.94 -0.36 2.01e-11 Obesity (extreme); LUSC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg12751644 chr20:60527061 NA -0.34 -6.04 -0.31 4.13e-9 Body mass index; LUSC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -5.98 -0.31 5.8e-9 Life satisfaction; LUSC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.2 0.41 5.41e-15 Electroencephalogram traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21715212 chr22:45406639 PHF21B 0.44 7.38 0.37 1.29e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs1728785 0.818 rs1069289 chr16:68585317 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.73 0.39 1.27e-13 Ulcerative colitis; LUSC cis rs62458065 0.925 rs10243243 chr7:32460709 A/G cg20159608 chr7:32802032 NA -0.59 -7.1 -0.36 7.58e-12 Metabolite levels (HVA/MHPG ratio); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00573355 chr2:74730266 LBX2;LOC151534 -0.39 -6.09 -0.32 3.07e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg26647111 chr11:31128758 NA -0.43 -6.12 -0.32 2.58e-9 Red blood cell count; LUSC trans rs11039798 0.764 rs1121450 chr11:48897476 C/T cg03929089 chr4:120376271 NA 0.71 6.57 0.34 1.9e-10 Axial length; LUSC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg22875332 chr1:76189707 ACADM -0.88 -14.1 -0.61 9.21e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg26727032 chr16:67993705 SLC12A4 -0.44 -5.94 -0.31 7.12e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6685188 0.925 rs12752037 chr1:205661614 A/C cg14159672 chr1:205819179 PM20D1 -0.41 -5.93 -0.31 7.61e-9 White blood cell count (basophil);Basophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05654422 chr17:80709806 TBCD -0.41 -6.13 -0.32 2.44e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg17420585 chr12:42539391 GXYLT1 -0.36 -6.92 -0.35 2.26e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6121246 0.567 rs6060261 chr20:30192948 C/G cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs798766 1.000 rs1665366 chr4:1728381 A/G cg07041428 chr4:1763019 NA 0.38 5.66 0.3 3.29e-8 Bladder cancer;Urinary bladder cancer; LUSC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.93e-12 Blood metabolite levels; LUSC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.05e-10 Aortic root size; LUSC cis rs4132509 0.793 rs7538011 chr1:243703344 A/G cg21452805 chr1:244014465 NA 0.6 6.14 0.32 2.34e-9 RR interval (heart rate); LUSC cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.84 -0.44 5.72e-17 Axial length; LUSC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg22442454 chr1:209979470 IRF6 0.43 5.88 0.31 9.86e-9 Cleft lip with or without cleft palate; LUSC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg22963979 chr7:1858916 MAD1L1 -0.58 -8.85 -0.44 5.12e-17 Bipolar disorder and schizophrenia; LUSC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg26695010 chr11:65641043 EFEMP2 -0.47 -7.08 -0.36 8.8e-12 Breast cancer; LUSC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 12.61 0.57 4.47e-30 Total body bone mineral density; LUSC cis rs9807989 1.000 rs9807989 chr2:102971200 T/C cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg17554472 chr22:41940697 POLR3H 0.48 5.91 0.31 8.32e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.9 0.44 3.72e-17 Menopause (age at onset); LUSC cis rs4356932 1.000 rs4859588 chr4:76943677 C/T cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg05855489 chr10:104503620 C10orf26 0.61 8.98 0.44 1.99e-17 Arsenic metabolism; LUSC cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg13256891 chr4:100009986 ADH5 -0.45 -6.26 -0.32 1.18e-9 Alcohol dependence; LUSC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg03477792 chr4:77819574 ANKRD56 0.61 8.87 0.44 4.5e-17 Emphysema distribution in smoking; LUSC cis rs300703 0.935 rs10193882 chr2:246301 A/T cg21211680 chr2:198530 NA -0.66 -6.77 -0.35 5.92e-11 Blood protein levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg12307764 chr15:40861449 RPUSD2 0.44 7.1 0.36 7.73e-12 Triglycerides; LUSC cis rs12421382 0.659 rs35093943 chr11:109379872 C/A cg11473876 chr11:109292803 C11orf87 0.39 6.32 0.33 8.41e-10 Schizophrenia; LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs6665290 0.904 rs6426559 chr1:227195876 T/C cg10327440 chr1:227177885 CDC42BPA -1.22 -40.37 -0.91 1.58e-130 Myeloid white cell count; LUSC cis rs3743266 0.507 rs10162677 chr15:60748568 C/T cg21667061 chr15:60772094 NARG2 0.5 6.91 0.35 2.44e-11 Menarche (age at onset); LUSC trans rs1728785 1.000 rs1645935 chr16:68563791 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs6840360 0.571 rs4696275 chr4:152530981 C/T cg22705602 chr4:152727874 NA -0.33 -6.65 -0.34 1.23e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.74 -0.35 6.93e-11 Developmental language disorder (linguistic errors); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg19339932 chr22:20004356 ARVCF 0.37 6.09 0.32 3.08e-9 Metabolite levels (Pyroglutamine); LUSC trans rs1814175 0.817 rs4405313 chr11:50013636 G/A cg03929089 chr4:120376271 NA -1.03 -20.48 -0.75 5.94e-61 Height; LUSC cis rs478304 0.651 rs4014192 chr11:65498915 C/T cg10604040 chr11:65559109 OVOL1 0.31 5.72 0.3 2.34e-8 Acne (severe); LUSC cis rs9581857 0.547 rs76435345 chr13:28107638 G/A cg22138327 chr13:27999177 GTF3A 0.66 7.23 0.37 3.26e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg13256891 chr4:100009986 ADH5 0.51 6.89 0.35 2.74e-11 Smoking initiation; LUSC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.52 -7.25 -0.37 2.85e-12 Tuberculosis; LUSC cis rs7089973 0.604 rs11196939 chr10:116593175 A/G cg25233709 chr10:116636983 FAM160B1 -0.4 -6.97 -0.36 1.7e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9517320 0.515 rs72646416 chr13:99232916 C/G cg20487152 chr13:99095054 FARP1 -0.42 -6.96 -0.36 1.8e-11 Longevity; LUSC cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg06064525 chr11:970664 AP2A2 -0.35 -7.15 -0.36 5.53e-12 Alzheimer's disease (late onset); LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.64 0.6 5.64e-34 Platelet count; LUSC cis rs9837602 1.000 rs13069311 chr3:99801628 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.28 0.33 1.03e-9 Breast cancer; LUSC cis rs7945705 0.791 rs12421789 chr11:8813956 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -9.41 -0.46 8.25e-19 Hemoglobin concentration; LUSC cis rs4595586 0.545 rs12816776 chr12:39375817 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.42 0.69 8.19e-49 Chronic sinus infection; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg18056097 chr20:32441571 CHMP4B 0.44 6.02 0.31 4.6e-9 Neuroticism; LUSC trans rs2243480 0.908 rs4718273 chr7:65216099 G/A cg10756647 chr7:56101905 PSPH -0.85 -8.35 -0.42 1.87e-15 Diabetic kidney disease; LUSC cis rs7202877 0.706 rs247443 chr16:75465073 G/C cg03315344 chr16:75512273 CHST6 -0.45 -6.46 -0.33 3.69e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs911555 0.755 rs17841064 chr14:103900609 A/G cg24130564 chr14:104152367 KLC1 -0.43 -6.05 -0.31 3.83e-9 Intelligence (multi-trait analysis); LUSC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg17173187 chr15:85201210 NMB 0.37 6.56 0.34 2.08e-10 Schizophrenia; LUSC cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -7.65 -0.39 2.16e-13 Chronic sinus infection; LUSC cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg03146154 chr1:46216737 IPP 0.51 7.68 0.39 1.8e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.67e-9 Monocyte count; LUSC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.13 0.55 2.54e-28 Cognitive test performance; LUSC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 7.62 0.38 2.62e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 0.824 rs406753 chr12:34117408 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.95 0.36 1.9e-11 Morning vs. evening chronotype; LUSC cis rs4478037 1.000 rs59229836 chr3:33162622 T/C cg19404215 chr3:33155277 CRTAP 0.95 9.99 0.48 9.87e-21 Major depressive disorder; LUSC cis rs9479482 1.000 rs9478380 chr6:150354665 A/G cg00432049 chr6:150390894 ULBP3 0.29 6.08 0.32 3.25e-9 Alopecia areata; LUSC trans rs7937682 0.889 rs1784785 chr11:111483306 A/G cg18187862 chr3:45730750 SACM1L 0.54 7.07 0.36 8.98e-12 Primary sclerosing cholangitis; LUSC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg08213375 chr14:104286397 PPP1R13B 0.44 7.57 0.38 3.77e-13 Reticulocyte count; LUSC cis rs17270561 0.636 rs1185977 chr6:25829054 A/G cg16482183 chr6:26056742 HIST1H1C 0.56 7.96 0.4 2.75e-14 Iron status biomarkers; LUSC cis rs3540 0.574 rs2657947 chr15:90968977 C/T cg22089800 chr15:90895588 ZNF774 -0.59 -9.23 -0.45 3.11e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7829975 0.774 rs35431455 chr8:8673736 T/C cg06636001 chr8:8085503 FLJ10661 0.6 9.05 0.44 1.23e-17 Mood instability; LUSC cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg23583168 chr7:148888333 NA -0.92 -16.88 -0.68 1.19e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs61931739 0.500 rs6488211 chr12:34375620 A/T cg06521331 chr12:34319734 NA 0.43 6.8 0.35 4.75e-11 Morning vs. evening chronotype; LUSC cis rs2486288 0.656 rs11854325 chr15:45548959 T/C cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.76 -0.51 2.18e-23 Glomerular filtration rate; LUSC cis rs40363 0.720 rs4453493 chr16:3533881 T/C cg21433313 chr16:3507492 NAT15 -0.62 -9.43 -0.46 6.91e-19 Tuberculosis; LUSC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg11764359 chr7:65958608 NA -0.79 -13.28 -0.59 1.29e-32 Aortic root size; LUSC trans rs62103177 0.810 rs62103191 chr18:77628769 C/G cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs559928 0.606 rs57021319 chr11:63956102 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 6.99 0.36 1.47e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7523273 0.606 rs1970530 chr1:207924066 G/A cg22525895 chr1:207977042 MIR29B2 0.4 6.44 0.33 4.18e-10 Schizophrenia; LUSC cis rs10791097 0.690 rs12286234 chr11:130730528 T/C cg12179176 chr11:130786555 SNX19 0.73 11.94 0.55 1.37e-27 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs11122272 0.735 rs2808600 chr1:231534723 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.09 -0.48 4.6e-21 Hemoglobin concentration; LUSC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.18 0.52 7.02e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs877282 0.629 rs78997110 chr10:764388 A/G cg13042288 chr15:90349979 ANPEP -0.46 -6.26 -0.32 1.21e-9 Uric acid levels; LUSC trans rs13390641 0.614 rs72932428 chr2:104095235 G/C cg03260781 chr1:16346299 HSPB7 -0.46 -6.09 -0.32 3.14e-9 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs11971779 0.680 rs10229249 chr7:139052510 A/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC trans rs7937682 0.924 rs1784782 chr11:111525764 A/C cg18187862 chr3:45730750 SACM1L 0.56 7.06 0.36 9.52e-12 Primary sclerosing cholangitis; LUSC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.62 8.54 0.42 4.67e-16 Multiple sclerosis; LUSC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg23711669 chr6:146136114 FBXO30 0.82 14.38 0.62 8.11e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs710216 0.536 rs710221 chr1:43414200 G/A cg07803811 chr1:43423981 SLC2A1 0.43 6.47 0.33 3.45e-10 Red cell distribution width; LUSC cis rs7100689 0.622 rs4536152 chr10:82119242 C/T cg01528321 chr10:82214614 TSPAN14 0.84 12.81 0.57 7.92e-31 Post bronchodilator FEV1; LUSC cis rs9815354 0.556 rs113213296 chr3:41873097 G/A cg03022575 chr3:42003672 ULK4 0.84 8.86 0.44 4.79e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.32 0.53 2.37e-25 Prudent dietary pattern; LUSC cis rs7769051 0.522 rs73554461 chr6:133139087 T/G cg07930552 chr6:133119739 C6orf192 0.95 9.42 0.46 7.64e-19 Type 2 diabetes nephropathy; LUSC cis rs796364 0.806 rs79053279 chr2:201057443 C/T cg23649088 chr2:200775458 C2orf69 -0.57 -6.73 -0.35 7.26e-11 Schizophrenia; LUSC cis rs7833790 0.750 rs10108955 chr8:82690644 C/T cg17211192 chr8:82754475 SNX16 -0.76 -10.02 -0.48 7.93e-21 Diastolic blood pressure; LUSC cis rs2742417 1.000 rs2742452 chr3:45765708 C/T cg04837898 chr3:45731254 SACM1L -0.38 -6.33 -0.33 7.89e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs9905704 0.633 rs2531731 chr17:56546524 A/C cg12560992 chr17:57184187 TRIM37 -0.5 -5.69 -0.3 2.83e-8 Testicular germ cell tumor; LUSC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.53 8.58 0.42 3.71e-16 Bipolar disorder; LUSC cis rs11605924 0.934 rs7945689 chr11:45879006 C/T ch.11.939596F chr11:45881766 CRY2 -0.55 -8.39 -0.42 1.38e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2857891 0.778 rs7118671 chr11:6934002 C/G cg04053776 chr11:6947353 ZNF215 0.47 6.93 0.35 2.15e-11 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs4714291 0.963 rs9369159 chr6:39998853 T/C cg02267698 chr19:7991119 CTXN1 0.51 7.25 0.37 2.85e-12 Strep throat; LUSC cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -6.33 -0.33 7.74e-10 Schizophrenia; LUSC cis rs6500602 0.647 rs1641868 chr16:4594503 G/C cg08645402 chr16:4508243 NA 0.45 7.48 0.38 6.46e-13 Schizophrenia; LUSC cis rs9611565 0.921 rs6002333 chr22:41719469 C/T cg03806693 chr22:41940476 POLR3H -0.79 -11.6 -0.54 2.22e-26 Vitiligo; LUSC cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -13.43 -0.59 3.53e-33 Intelligence (multi-trait analysis); LUSC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg08859206 chr1:53392774 SCP2 -0.41 -6.62 -0.34 1.4e-10 Monocyte count; LUSC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg00509249 chr6:109615579 CCDC162 0.34 6.03 0.31 4.4e-9 Reticulocyte fraction of red cells; LUSC cis rs72781680 0.898 rs55657921 chr2:24008091 C/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs694739 0.964 rs2510066 chr11:64052447 C/T cg26898376 chr11:64110657 CCDC88B 0.36 6.71 0.34 8.36e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs9784649 1.000 rs11738315 chr5:24967891 T/C cg08600765 chr20:34638493 LOC647979 -0.57 -6.51 -0.34 2.74e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6964587 1.000 rs1859114 chr7:91682848 T/C cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs6138458 0.620 rs914314 chr20:24897355 C/T cg06937882 chr20:24974362 C20orf3 0.49 6.12 0.32 2.61e-9 Blood protein levels; LUSC trans rs11148252 0.740 rs3803264 chr13:52971893 A/G cg18335740 chr13:41363409 SLC25A15 -0.58 -9.13 -0.45 6.52e-18 Lewy body disease; LUSC trans rs7824557 0.734 rs2293856 chr8:11177447 C/T cg15556689 chr8:8085844 FLJ10661 0.57 8.71 0.43 1.46e-16 Retinal vascular caliber; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.44 0.53 8.75e-26 Prudent dietary pattern; LUSC cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg00071950 chr4:10020882 SLC2A9 0.64 10.89 0.51 8.04e-24 Bone mineral density; LUSC cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg11584989 chr19:19387371 SF4 0.66 7.6 0.38 3e-13 Bipolar disorder; LUSC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg05785598 chr3:49045655 WDR6 0.36 6.0 0.31 5.28e-9 Parkinson's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00300090 chr3:4345167 SETMAR -0.49 -6.61 -0.34 1.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg21984481 chr17:79567631 NPLOC4 -0.56 -10.73 -0.51 2.91e-23 Eye color traits; LUSC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg03605463 chr16:89740564 NA -0.57 -9.01 -0.44 1.67e-17 Vitiligo; LUSC trans rs1005277 0.579 rs2472178 chr10:38384750 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.52 -0.46 3.61e-19 Extrinsic epigenetic age acceleration; LUSC trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21659725 chr3:3221576 CRBN -0.58 -8.2 -0.41 5.33e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs7520050 0.751 rs592214 chr1:46024505 G/A cg06784218 chr1:46089804 CCDC17 -0.31 -5.93 -0.31 7.54e-9 Red blood cell count;Reticulocyte count; LUSC cis rs754466 0.580 rs12357670 chr10:79558180 T/C cg17075019 chr10:79541650 NA -0.76 -11.97 -0.55 1e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12410462 0.681 rs6681096 chr1:227609720 G/A cg10327440 chr1:227177885 CDC42BPA -0.64 -5.78 -0.3 1.73e-8 Major depressive disorder; LUSC cis rs10100465 0.924 rs1021014 chr8:118661891 G/A cg09430518 chr8:118662568 NA -0.29 -5.64 -0.3 3.57e-8 Leprosy; LUSC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.81 0.39 7.63e-14 Major depressive disorder; LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.58 0.38 3.42e-13 Calcium levels; LUSC cis rs6545883 0.826 rs1186697 chr2:61661417 G/A cg15711740 chr2:61764176 XPO1 -0.44 -6.56 -0.34 2.11e-10 Tuberculosis; LUSC cis rs2439831 1.000 rs689826 chr15:43749916 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.78 0.43 8.38e-17 Lung cancer in ever smokers; LUSC cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.71 0.65 4.91e-42 Morning vs. evening chronotype; LUSC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg08917208 chr2:24149416 ATAD2B 0.56 6.27 0.32 1.12e-9 Lymphocyte counts; LUSC cis rs78545713 0.649 rs77362785 chr6:26232351 G/A cg23601095 chr6:26197514 HIST1H3D 0.67 5.68 0.3 2.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs9650315 0.586 rs35798072 chr8:57207926 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.64 7.8 0.39 7.83e-14 Height; LUSC cis rs2273669 0.667 rs7767882 chr6:109334971 C/A cg05315195 chr6:109294784 ARMC2 -0.53 -5.89 -0.31 9.28e-9 Prostate cancer; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg24503407 chr1:205819492 PM20D1 1.01 22.71 0.78 1.06e-69 Menarche (age at onset); LUSC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg18827107 chr12:86230957 RASSF9 0.46 6.92 0.35 2.3e-11 Major depressive disorder; LUSC cis rs6545883 0.894 rs6709441 chr2:61436930 A/T cg15711740 chr2:61764176 XPO1 0.45 6.64 0.34 1.3e-10 Tuberculosis; LUSC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg13628971 chr7:2884303 GNA12 0.39 5.92 0.31 8.06e-9 Height; LUSC cis rs1372520 0.684 rs2619347 chr4:90745770 G/A cg01966878 chr4:90757139 SNCA -0.42 -6.05 -0.31 3.86e-9 Neuroticism; LUSC cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.19 -0.45 4.23e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4499344 0.633 rs259251 chr19:33149768 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.42 0.53 1.02e-25 Mean platelet volume; LUSC cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg17507749 chr15:85114479 UBE2QP1 0.57 7.25 0.37 2.99e-12 Schizophrenia; LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.03 0.52 2.57e-24 Menopause (age at onset); LUSC cis rs708547 0.581 rs6554400 chr4:57805306 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.51 -7.57 -0.38 3.74e-13 Response to bleomycin (chromatid breaks); LUSC cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg18681998 chr4:17616180 MED28 0.84 15.44 0.65 5.89e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14016680 chr3:197687242 LMLN;IQCG -0.4 -6.03 -0.31 4.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7589342 0.536 rs7563690 chr2:106396935 C/T cg09152813 chr2:106391379 NCK2 -0.39 -6.3 -0.33 9.19e-10 Addiction; LUSC cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7572644 0.608 rs75429814 chr2:27961614 T/C cg27432699 chr2:27873401 GPN1 0.6 7.37 0.37 1.36e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg08975724 chr8:8085496 FLJ10661 -0.5 -7.44 -0.38 8.62e-13 Mood instability; LUSC cis rs3126085 0.935 rs10788824 chr1:152161694 A/G cg26876637 chr1:152193138 HRNR 0.48 6.58 0.34 1.81e-10 Atopic dermatitis; LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -9.61 -0.47 1.88e-19 Bipolar disorder and schizophrenia; LUSC cis rs72960926 0.744 rs72954314 chr6:74939737 A/G cg03266952 chr6:74778945 NA -0.84 -6.98 -0.36 1.57e-11 Metabolite levels (MHPG); LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg27284194 chr4:1044797 NA 0.35 5.83 0.3 1.32e-8 Obesity-related traits; LUSC cis rs2108225 0.934 rs4730269 chr7:107455719 T/G cg18560240 chr7:107437656 SLC26A3 -0.43 -6.43 -0.33 4.3e-10 Ulcerative colitis; LUSC cis rs10911251 0.546 rs10911260 chr1:183106230 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.69 -10.55 -0.5 1.2e-22 Colorectal cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12593303 chr2:54785406 SPTBN1 0.43 6.04 0.31 4.11e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs28830936 0.966 rs4924576 chr15:42119593 C/A cg17847044 chr15:42102381 MAPKBP1 -0.26 -5.78 -0.3 1.75e-8 Diastolic blood pressure; LUSC cis rs950027 0.620 rs872192 chr15:45614502 A/G cg26924012 chr15:45694286 SPATA5L1 0.8 12.45 0.56 1.8e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs11250098 0.583 rs66724331 chr8:10789345 C/A cg21775007 chr8:11205619 TDH -0.51 -7.0 -0.36 1.41e-11 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs2389269 chr12:34034179 C/T cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 2.92e-25 Morning vs. evening chronotype; LUSC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg11764359 chr7:65958608 NA 0.49 6.15 0.32 2.16e-9 Aortic root size; LUSC cis rs7617773 0.925 rs6442105 chr3:48182326 A/G cg20734569 chr3:48348370 SPINK8 0.46 8.13 0.41 8.54e-15 Coronary artery disease; LUSC cis rs11098499 0.866 rs12513310 chr4:120288039 T/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg11764359 chr7:65958608 NA -0.69 -10.46 -0.5 2.43e-22 Aortic root size; LUSC cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg19230755 chr7:65878503 NA -0.44 -6.03 -0.31 4.39e-9 Aortic root size; LUSC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg00033643 chr7:134001901 SLC35B4 0.45 7.05 0.36 1.02e-11 Mean platelet volume; LUSC cis rs28647808 0.881 rs4549850 chr9:136265239 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.93 -0.31 7.37e-9 Blood protein levels; LUSC cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg12011299 chr4:100065546 ADH4 0.71 10.85 0.51 1.08e-23 Smoking initiation; LUSC cis rs17155006 0.746 rs370495 chr7:107746246 T/C cg05962710 chr7:107745446 LAMB4 -0.36 -6.43 -0.33 4.42e-10 Pneumococcal bacteremia; LUSC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg21775007 chr8:11205619 TDH -0.47 -6.93 -0.35 2.2e-11 Neuroticism; LUSC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -11.62 -0.54 1.88e-26 Schizophrenia; LUSC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.72 0.47 7.69e-20 Personality dimensions; LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg11645453 chr3:52864694 ITIH4 0.35 8.05 0.4 1.44e-14 Bipolar disorder; LUSC cis rs908922 0.676 rs478926 chr1:152511533 G/T cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg27535305 chr1:53392650 SCP2 -0.41 -7.49 -0.38 6.38e-13 Monocyte count; LUSC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg07701084 chr6:150067640 NUP43 0.55 8.42 0.42 1.09e-15 Lung cancer; LUSC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.48 0.53 5.96e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs13089785 1.000 rs13071800 chr3:123626813 C/A cg02012769 chr3:123398346 MYLK 0.32 5.88 0.31 1.02e-8 Intelligence (multi-trait analysis); LUSC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg15744005 chr10:104629667 AS3MT -0.34 -6.95 -0.36 1.91e-11 Arsenic metabolism; LUSC cis rs73198271 0.515 rs78790772 chr8:8634367 A/G cg01851573 chr8:8652454 MFHAS1 0.58 6.54 0.34 2.28e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7131987 0.621 rs11050181 chr12:29467669 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.72 -0.34 7.98e-11 QT interval; LUSC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg06022373 chr22:39101656 GTPBP1 0.78 12.16 0.55 2.1e-28 Menopause (age at onset); LUSC cis rs2795502 1.000 rs2744092 chr10:43339343 T/C cg20628663 chr10:43360327 NA -0.76 -11.4 -0.53 1.23e-25 Blood protein levels; LUSC cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg13010199 chr12:38710504 ALG10B 0.68 10.71 0.51 3.28e-23 Bladder cancer; LUSC cis rs240764 0.782 rs239223 chr6:101112345 A/G cg09795085 chr6:101329169 ASCC3 0.41 5.98 0.31 5.69e-9 Neuroticism; LUSC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg06505273 chr16:24850292 NA 0.41 5.75 0.3 2e-8 Intelligence (multi-trait analysis); LUSC cis rs9660992 0.674 rs12122105 chr1:205256818 C/T cg21643547 chr1:205240462 TMCC2 -0.49 -9.28 -0.45 2.14e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs559928 0.606 rs55970968 chr11:63961433 C/T cg05555928 chr11:63887634 MACROD1 -0.48 -6.03 -0.31 4.41e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2282802 0.685 rs6867870 chr5:139641896 C/A cg26211634 chr5:139558579 C5orf32 0.44 8.3 0.41 2.59e-15 Intelligence (multi-trait analysis); LUSC cis rs1790761 0.692 rs1148883 chr11:67304686 A/G cg23188684 chr11:67383651 NA 0.34 6.05 0.31 3.94e-9 Mean corpuscular volume; LUSC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg04727924 chr7:799746 HEATR2 -0.57 -6.81 -0.35 4.69e-11 Cerebrospinal P-tau181p levels; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.6 0.54 2.33e-26 Prudent dietary pattern; LUSC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.41 -0.38 1.02e-12 Developmental language disorder (linguistic errors); LUSC trans rs10511400 0.764 rs1259457 chr3:120200667 A/G cg13423759 chr1:37937403 NA -0.41 -6.01 -0.31 4.95e-9 Economic and political preferences (feminism/equality); LUSC cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg10523679 chr1:76189770 ACADM -0.53 -7.85 -0.39 5.89e-14 Daytime sleep phenotypes; LUSC cis rs7843479 0.601 rs7220 chr8:21863290 G/A cg17168535 chr8:21777572 XPO7 0.79 13.95 0.61 3.5e-35 Mean corpuscular volume; LUSC trans rs3812049 0.826 rs34576922 chr5:127364103 C/G cg16011800 chr17:1958478 HIC1 0.45 6.14 0.32 2.37e-9 Lymphocyte counts;Red cell distribution width; LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.72 11.09 0.52 1.51e-24 Lymphocyte counts; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg21724239 chr8:58056113 NA 0.8 8.46 0.42 8.32e-16 Developmental language disorder (linguistic errors); LUSC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg00033643 chr7:134001901 SLC35B4 0.47 7.28 0.37 2.36e-12 Mean platelet volume; LUSC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23221052 chr5:179740743 GFPT2 0.62 10.23 0.49 1.54e-21 Height; LUSC cis rs977987 0.778 rs1109341 chr16:75445605 G/A cg03315344 chr16:75512273 CHST6 0.47 8.63 0.43 2.48e-16 Dupuytren's disease; LUSC cis rs4363385 0.818 rs946095 chr1:153006470 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.44e-8 Inflammatory skin disease; LUSC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs9584850 0.834 rs7334078 chr13:99120484 C/T cg07423050 chr13:99094983 FARP1 -0.37 -6.38 -0.33 5.93e-10 Neuroticism; LUSC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg25036284 chr2:26402008 FAM59B -0.61 -7.86 -0.4 5.38e-14 Gut microbiome composition (summer); LUSC cis rs4343996 0.521 rs10233684 chr7:3424405 A/G cg21248987 chr7:3385318 SDK1 0.37 6.3 0.33 9.65e-10 Motion sickness; LUSC cis rs12602901 0.519 rs238238 chr17:4856376 A/G cg19427746 chr17:4889932 CAMTA2 -0.35 -6.31 -0.33 9e-10 Blood metabolite levels; LUSC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg18876405 chr7:65276391 NA 0.6 9.69 0.47 1.02e-19 Aortic root size; LUSC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15369054 chr17:80825471 TBCD 0.72 12.44 0.56 1.9e-29 Breast cancer; LUSC cis rs2835872 0.758 rs1709817 chr21:39036349 T/A cg20424643 chr21:39039972 KCNJ6 -0.44 -7.43 -0.38 8.98e-13 Electroencephalographic traits in alcoholism; LUSC cis rs12458462 0.851 rs3859317 chr18:77443093 A/C cg11879182 chr18:77439856 CTDP1 0.72 11.91 0.55 1.68e-27 Monocyte count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10667969 chr3:149181941 NA 0.5 7.42 0.38 9.64e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg21643547 chr1:205240462 TMCC2 -0.5 -9.3 -0.45 1.95e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs73198271 0.628 rs11776981 chr8:8589459 C/T cg01851573 chr8:8652454 MFHAS1 0.48 6.02 0.31 4.52e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg07677032 chr17:61819896 STRADA 0.52 8.71 0.43 1.4e-16 Prudent dietary pattern; LUSC cis rs6429082 0.660 rs10737818 chr1:235542023 A/G cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.87 -0.35 3.11e-11 Adiposity; LUSC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg09699651 chr6:150184138 LRP11 0.37 5.7 0.3 2.61e-8 Lung cancer; LUSC cis rs5167 0.533 rs55778858 chr19:45485465 G/A cg25746394 chr19:45450501 APOC2 0.32 6.07 0.32 3.55e-9 Blood protein levels; LUSC cis rs699 0.545 rs2478524 chr1:230836276 G/C cg07502417 chr1:230849801 AGT -0.28 -6.19 -0.32 1.78e-9 Coronary artery disease; LUSC cis rs54211 1.000 rs137608 chr22:39696887 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.6 5.78 0.3 1.72e-8 Sudden cardiac arrest; LUSC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg17633681 chr16:88106987 BANP 0.52 9.86 0.47 2.63e-20 Menopause (age at onset); LUSC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg00343986 chr7:65444356 GUSB -0.38 -5.73 -0.3 2.29e-8 Aortic root size; LUSC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg14019146 chr3:50243930 SLC38A3 -0.32 -7.06 -0.36 9.67e-12 Intelligence (multi-trait analysis); LUSC cis rs240764 0.631 rs12195369 chr6:101204106 G/A cg09795085 chr6:101329169 ASCC3 -0.41 -6.03 -0.31 4.43e-9 Neuroticism; LUSC cis rs1801251 1.000 rs71421663 chr2:233619131 A/G cg08000102 chr2:233561755 GIGYF2 0.69 11.51 0.53 4.63e-26 Coronary artery disease; LUSC cis rs11971779 0.588 rs2003531 chr7:139126578 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.15 0.36 5.57e-12 Diisocyanate-induced asthma; LUSC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg00343986 chr7:65444356 GUSB 0.47 7.14 0.36 5.91e-12 Aortic root size; LUSC cis rs62229266 0.804 rs62230821 chr21:37425116 C/T cg12218747 chr21:37451666 NA -0.38 -5.67 -0.3 3.14e-8 Mitral valve prolapse; LUSC cis rs10489202 0.632 rs203779 chr1:167877647 T/G cg24449463 chr1:168025552 DCAF6 -0.73 -11.52 -0.53 4.39e-26 Schizophrenia; LUSC cis rs72700829 0.531 rs955955 chr1:151011543 G/A cg11822372 chr1:151115635 SEMA6C -0.74 -6.7 -0.34 8.74e-11 Schizophrenia; LUSC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.55 6.48 0.33 3.26e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg08645402 chr16:4508243 NA 0.47 7.4 0.38 1.14e-12 Schizophrenia; LUSC cis rs6977660 0.714 rs1468287 chr7:19784210 T/A cg05791153 chr7:19748676 TWISTNB 0.76 7.49 0.38 6.33e-13 Thyroid stimulating hormone; LUSC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg16240275 chr20:61666158 NCRNA00029 0.41 9.04 0.44 1.27e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg23719950 chr11:63933701 MACROD1 -0.62 -8.07 -0.4 1.29e-14 Mean platelet volume; LUSC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs72634258 0.945 rs225120 chr1:8046378 C/T cg26816564 chr1:7831052 VAMP3 0.43 5.85 0.3 1.16e-8 Inflammatory bowel disease; LUSC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg10645314 chr2:3704589 ALLC -0.47 -7.18 -0.37 4.47e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg27266060 chr8:22091797 NA 0.4 7.24 0.37 3.1e-12 Hypertriglyceridemia; LUSC trans rs4714291 0.928 rs1923461 chr6:39984670 A/T cg02267698 chr19:7991119 CTXN1 0.52 7.28 0.37 2.34e-12 Strep throat; LUSC cis rs10484885 0.887 rs2273246 chr6:90453263 A/G cg13799429 chr6:90582589 CASP8AP2 -0.91 -10.67 -0.5 4.44e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7940866 0.903 rs7130842 chr11:130836269 A/G cg12179176 chr11:130786555 SNX19 0.57 8.91 0.44 3.31e-17 Schizophrenia; LUSC cis rs1691799 0.867 rs1495497 chr12:66770020 A/T cg16791601 chr12:66731901 HELB -0.68 -12.01 -0.55 7.53e-28 White blood cell count (basophil); LUSC cis rs8060686 0.641 rs112099181 chr16:68154230 T/C cg04539111 chr16:67997858 SLC12A4 -0.41 -5.66 -0.3 3.28e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs9693857 1.000 rs9693857 chr8:9267117 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -6.56 -0.34 2.06e-10 Systolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26243254 chr12:132434651 EP400 -0.44 -6.61 -0.34 1.51e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1577917 1.000 rs2812972 chr6:86669880 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.42 -6.2 -0.32 1.71e-9 Response to antipsychotic treatment; LUSC cis rs644799 0.526 rs568120 chr11:95578734 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.65 9.43 0.46 7.41e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6542838 0.671 rs6752025 chr2:99505699 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.61 -0.34 1.54e-10 Fear of minor pain; LUSC cis rs11971779 0.680 rs7783619 chr7:139061437 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.2 0.32 1.67e-9 Diisocyanate-induced asthma; LUSC trans rs12579753 0.879 rs12829053 chr12:82161926 T/A cg07923666 chr12:49932857 KCNH3 -0.52 -6.75 -0.35 6.56e-11 Resting heart rate; LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg00945038 chr17:61921165 SMARCD2 0.53 9.33 0.45 1.54e-18 Prudent dietary pattern; LUSC cis rs2361710 0.611 rs12451471 chr17:78102517 C/T cg09238746 chr17:78121135 EIF4A3 -0.44 -6.15 -0.32 2.16e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs72949976 0.564 rs4673730 chr2:214024836 G/T cg08319019 chr2:214017104 IKZF2 0.68 11.5 0.53 5.01e-26 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs4423214 0.879 rs1792282 chr11:71135166 G/A cg05163923 chr11:71159392 DHCR7 -0.66 -8.63 -0.43 2.56e-16 Vitamin D levels; LUSC cis rs13082711 0.595 rs13075389 chr3:27339586 C/T cg02860705 chr3:27208620 NA 0.74 12.09 0.55 3.79e-28 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg02782426 chr3:40428986 ENTPD3 0.37 7.0 0.36 1.4e-11 Renal cell carcinoma; LUSC cis rs11030122 0.673 rs11030660 chr11:4043268 T/C cg18678763 chr11:4115507 RRM1 -0.45 -6.0 -0.31 5.12e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs701145 0.585 rs1470662 chr3:153870997 T/G cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs11785400 0.793 rs1137521 chr8:143739162 C/T cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs7428 1.000 rs7428 chr2:85545490 C/T cg24342717 chr2:85555507 TGOLN2 0.6 8.79 0.43 7.98e-17 Ear protrusion; LUSC cis rs17824933 0.943 rs11230562 chr11:60776186 C/T cg16817237 chr11:60793675 NA 0.41 6.46 0.33 3.75e-10 Multiple sclerosis; LUSC trans rs4714291 0.963 rs1767672 chr6:40104107 G/T cg02267698 chr19:7991119 CTXN1 0.51 7.06 0.36 9.79e-12 Strep throat; LUSC cis rs9547692 0.938 rs7333607 chr13:37462010 A/G cg01493522 chr13:37497338 NA -0.4 -5.92 -0.31 7.92e-9 Coronary artery disease; LUSC cis rs7216064 1.000 rs62084246 chr17:65867911 G/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2274273 0.870 rs7160523 chr14:55594560 G/T cg04306507 chr14:55594613 LGALS3 0.58 13.33 0.59 8.58e-33 Protein biomarker; LUSC cis rs7084921 0.608 rs12780514 chr10:101865884 T/C cg11888571 chr10:102027403 CWF19L1 -0.42 -5.84 -0.3 1.27e-8 Bone mineral density; LUSC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg03806693 chr22:41940476 POLR3H 1.0 13.8 0.6 1.32e-34 Vitiligo; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg08843538 chr2:210288784 MAP2 -0.44 -6.14 -0.32 2.29e-9 Height; LUSC cis rs11997175 0.625 rs4268088 chr8:33599343 A/T ch.8.33884649F chr8:33765107 NA 0.42 6.63 0.34 1.38e-10 Body mass index; LUSC cis rs950169 0.881 rs4842852 chr15:84941961 A/G cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs447735 0.587 rs258336 chr16:89720831 A/C cg03605463 chr16:89740564 NA 0.52 8.36 0.42 1.75e-15 Hemoglobin concentration; LUSC cis rs10484885 0.757 rs12215741 chr6:90154845 G/A cg13799429 chr6:90582589 CASP8AP2 -0.62 -5.92 -0.31 8.02e-9 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1335645 0.502 rs646734 chr1:111628733 A/G cg00321911 chr1:111669324 DRAM2 0.57 6.41 0.33 5.03e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7824557 0.767 rs6985146 chr8:11170721 A/C cg21775007 chr8:11205619 TDH 0.73 11.28 0.53 3.17e-25 Retinal vascular caliber; LUSC cis rs8040855 0.557 rs9744503 chr15:85724217 T/C cg04831495 chr15:85060580 GOLGA6L5 0.4 6.68 0.34 1.03e-10 Bulimia nervosa; LUSC trans rs11165623 0.624 rs11165665 chr1:97007925 T/C cg10631902 chr5:14652156 NA -0.4 -6.06 -0.31 3.64e-9 Hip circumference;Waist circumference; LUSC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg11645453 chr3:52864694 ITIH4 -0.39 -9.0 -0.44 1.73e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg22834771 chr12:69754056 YEATS4 0.51 7.68 0.39 1.77e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg27170947 chr2:26402098 FAM59B -0.62 -8.93 -0.44 2.81e-17 Gut microbiome composition (summer); LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg08888203 chr3:10149979 C3orf24 0.66 9.2 0.45 4.01e-18 Alzheimer's disease; LUSC cis rs992157 1.000 rs6736362 chr2:219115108 C/T cg00012203 chr2:219082015 ARPC2 0.81 13.75 0.6 2.12e-34 Colorectal cancer; LUSC cis rs4073416 0.542 rs8010726 chr14:65932597 C/T cg03016385 chr14:66212404 NA -0.41 -6.42 -0.33 4.65e-10 N-glycan levels; LUSC cis rs12594515 1.000 rs35182335 chr15:45995184 C/G cg01629716 chr15:45996671 NA 0.39 5.87 0.31 1.08e-8 Waist circumference;Weight; LUSC cis rs2635047 0.935 rs2576031 chr18:44658146 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.49 7.67 0.39 1.95e-13 Educational attainment; LUSC trans rs804280 0.662 rs11784764 chr8:11610874 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -6.4 -0.33 5.3e-10 Myopia (pathological); LUSC cis rs9814567 1.000 rs6763093 chr3:134254995 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.88 0.6 6.88e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg24829409 chr8:58192753 C8orf71 -0.55 -5.82 -0.3 1.38e-8 Developmental language disorder (linguistic errors); LUSC cis rs2274273 0.638 rs9919921 chr14:55695505 A/G cg04306507 chr14:55594613 LGALS3 0.48 9.57 0.46 2.43e-19 Protein biomarker; LUSC cis rs11168618 0.846 rs11168577 chr12:48842592 C/T cg24011408 chr12:48396354 COL2A1 0.38 6.07 0.32 3.48e-9 Adiponectin levels; LUSC trans rs7849782 0.967 rs7038036 chr9:104414233 T/G cg22914338 chr19:14376960 NA 0.26 6.48 0.33 3.2e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs72781680 0.898 rs12623333 chr2:24111823 T/G cg20701182 chr2:24300061 SF3B14 0.55 5.83 0.3 1.32e-8 Lymphocyte counts; LUSC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg04398451 chr17:18023971 MYO15A 0.44 6.96 0.36 1.77e-11 Total body bone mineral density; LUSC cis rs10887741 0.646 rs12257469 chr10:89437129 G/A cg13926569 chr10:89418898 PAPSS2 0.32 6.79 0.35 5.26e-11 Exercise (leisure time); LUSC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg17366294 chr4:99064904 C4orf37 0.55 9.51 0.46 3.92e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.863 rs1010739 chr4:120463471 C/T cg09307838 chr4:120376055 NA 0.72 10.2 0.49 1.85e-21 Corneal astigmatism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15367106 chr12:96184558 NTN4 0.48 6.49 0.33 3.1e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6502050 0.835 rs7405738 chr17:80084227 A/G cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs8016982 0.633 rs9944085 chr14:81717620 A/T cg01989461 chr14:81687754 GTF2A1 -0.68 -12.07 -0.55 4.34e-28 Schizophrenia; LUSC cis rs35000415 0.938 rs10488631 chr7:128594183 T/C cg19972273 chr7:128594194 NA 0.67 6.79 0.35 5.17e-11 Systemic lupus erythematosus; LUSC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg26850624 chr5:429559 AHRR -0.43 -8.44 -0.42 1.01e-15 Cystic fibrosis severity; LUSC trans rs11098499 0.615 rs28850368 chr4:120554313 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.53 0.34 2.38e-10 Corneal astigmatism; LUSC cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.52e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs2414059 0.518 rs2289108 chr15:50782335 G/A cg06848185 chr17:75368902 SEPT9 0.37 6.18 0.32 1.88e-9 QT interval; LUSC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12200560 0.505 rs211183 chr6:97074723 G/T cg06623918 chr6:96969491 KIAA0776 -0.49 -7.18 -0.37 4.6e-12 Coronary heart disease; LUSC trans rs6598955 0.671 rs11247900 chr1:26612460 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -8.86 -0.44 4.74e-17 Obesity-related traits; LUSC cis rs778371 0.697 rs6717048 chr2:233586427 T/C cg08000102 chr2:233561755 GIGYF2 0.81 14.02 0.61 2.01e-35 Schizophrenia; LUSC cis rs6964587 1.000 rs13245393 chr7:91641928 A/G cg17063962 chr7:91808500 NA 0.58 9.25 0.45 2.71e-18 Breast cancer; LUSC cis rs41271951 0.512 rs12090246 chr1:151107496 G/A cg11822372 chr1:151115635 SEMA6C -0.74 -6.73 -0.35 7.24e-11 Blood protein levels; LUSC cis rs7011049 1.000 rs4521776 chr8:53838833 G/C cg26025543 chr8:53854495 NA 0.52 6.3 0.33 9.5e-10 Systolic blood pressure; LUSC cis rs56283067 0.578 rs72862930 chr6:45361883 C/T cg20913747 chr6:44695427 NA -0.44 -6.42 -0.33 4.68e-10 Total body bone mineral density; LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg07507251 chr3:52567010 NT5DC2 0.33 6.19 0.32 1.72e-9 Bipolar disorder; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg26354017 chr1:205819088 PM20D1 -0.84 -15.2 -0.64 5.24e-40 Menarche (age at onset); LUSC cis rs2224391 0.911 rs9504368 chr6:5261460 A/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.47 -6.74 -0.35 7.14e-11 Height; LUSC cis rs2760061 0.583 rs708113 chr1:228192753 T/A cg02753203 chr1:228287806 NA 0.88 17.08 0.68 1.87e-47 Diastolic blood pressure; LUSC cis rs77106637 0.932 rs17244499 chr11:72629946 C/T cg03878208 chr11:72483293 STARD10 -0.56 -7.58 -0.38 3.37e-13 Type 2 diabetes; LUSC trans rs89107 0.688 rs372237 chr6:118608979 G/T cg11574620 chr4:80246899 NAA11 -0.36 -5.95 -0.31 6.73e-9 Cardiac structure and function; LUSC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.69 -0.47 9.62e-20 Gut microbiome composition (summer); LUSC cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.57e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.45 0.38 8.3e-13 Bipolar disorder; LUSC cis rs113835537 0.597 rs7116921 chr11:66303854 T/C cg24851651 chr11:66362959 CCS 0.53 7.97 0.4 2.52e-14 Airway imaging phenotypes; LUSC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg00074818 chr8:8560427 CLDN23 0.57 9.86 0.47 2.6e-20 Obesity-related traits; LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg00149659 chr3:10157352 C3orf10 0.91 12.44 0.56 1.89e-29 Alzheimer's disease; LUSC cis rs6901250 0.759 rs9489040 chr6:117131740 G/A cg12892004 chr6:117198278 RFX6 0.39 7.17 0.37 4.71e-12 C-reactive protein levels; LUSC cis rs75804782 0.521 rs66477197 chr2:239403832 C/T cg18131467 chr2:239335373 ASB1 -0.68 -6.24 -0.32 1.29e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.69 -0.34 9.46e-11 Monocyte percentage of white cells; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17605604 chr5:102612899 C5orf30 -0.45 -6.76 -0.35 6.09e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7481584 0.581 rs366422 chr11:3053873 C/T cg08508325 chr11:3079039 CARS 0.37 8.27 0.41 3.18e-15 Calcium levels; LUSC cis rs9300255 0.602 rs2682431 chr12:123703226 T/A cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs1448094 0.967 rs7974794 chr12:86323280 A/G cg02569458 chr12:86230093 RASSF9 0.42 6.71 0.34 8.49e-11 Major depressive disorder; LUSC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg05890377 chr2:74357713 NA 0.72 13.68 0.6 3.83e-34 Gestational age at birth (maternal effect); LUSC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg05872129 chr22:39784769 NA -0.61 -11.26 -0.52 3.86e-25 Intelligence (multi-trait analysis); LUSC cis rs2463822 1.000 rs72921501 chr11:62115622 A/T cg06239285 chr11:62104954 ASRGL1 -0.95 -10.27 -0.49 1.11e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg23625390 chr15:77176239 SCAPER 0.5 7.83 0.39 6.38e-14 Blood metabolite levels; LUSC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg06808227 chr14:105710500 BRF1 -0.66 -10.08 -0.48 4.97e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs968567 0.539 rs174549 chr11:61571382 A/G cg19610905 chr11:61596333 FADS2 0.55 8.06 0.4 1.41e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs4919087 1.000 rs10786326 chr10:99070377 G/A cg25902810 chr10:99078978 FRAT1 0.49 7.22 0.37 3.57e-12 Monocyte count; LUSC cis rs9902453 0.845 rs10853135 chr17:28188675 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.13 0.45 6.54e-18 Coffee consumption (cups per day); LUSC cis rs4363385 0.776 rs2879490 chr1:152947163 A/G cg00922841 chr1:152955080 SPRR1A -0.46 -7.55 -0.38 4.21e-13 Inflammatory skin disease; LUSC cis rs2404602 0.735 rs4886800 chr15:76678692 A/G cg23625390 chr15:77176239 SCAPER -0.57 -8.62 -0.43 2.76e-16 Blood metabolite levels; LUSC cis rs7481584 0.624 rs693687 chr11:3052494 A/G cg08508325 chr11:3079039 CARS 0.38 8.44 0.42 1e-15 Calcium levels; LUSC cis rs17270561 0.609 rs6924782 chr6:25735816 C/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs8028313 0.504 rs2899730 chr15:68172520 G/T cg08079166 chr15:68083412 MAP2K5 -0.34 -6.07 -0.32 3.52e-9 Obesity; LUSC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg23281280 chr6:28129359 ZNF389 0.43 5.71 0.3 2.47e-8 Depression; LUSC trans rs57221529 0.766 rs72703064 chr5:587825 T/C cg11887960 chr12:57824829 NA 0.56 6.84 0.35 3.75e-11 Lung disease severity in cystic fibrosis; LUSC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg14019146 chr3:50243930 SLC38A3 -0.36 -8.24 -0.41 4.02e-15 Body mass index; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg16145915 chr7:1198662 ZFAND2A -0.76 -17.37 -0.69 1.31e-48 Longevity;Endometriosis; LUSC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg19077165 chr18:44547161 KATNAL2 -0.38 -5.68 -0.3 2.99e-8 Personality dimensions; LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -11.28 -0.53 3.26e-25 Alzheimer's disease; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg23131131 chr22:24373011 LOC391322 -0.5 -7.3 -0.37 2.06e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg27446573 chr6:127587934 RNF146 0.92 15.33 0.64 1.58e-40 Breast cancer; LUSC cis rs9467773 1.000 rs6924838 chr6:26571756 C/T cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.7e-36 Intelligence (multi-trait analysis); LUSC cis rs9311676 0.632 rs1126722 chr3:58413518 T/G cg13750441 chr3:58318267 PXK 0.35 6.86 0.35 3.41e-11 Systemic lupus erythematosus; LUSC cis rs2742234 0.955 rs2075910 chr10:43614230 G/A cg15436174 chr10:43711423 RASGEF1A -0.37 -6.52 -0.34 2.66e-10 Hirschsprung disease; LUSC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg15448220 chr1:150897856 SETDB1 0.41 5.91 0.31 8.67e-9 Melanoma; LUSC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg05855489 chr10:104503620 C10orf26 0.61 8.87 0.44 4.4e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs8060686 0.641 rs75796305 chr16:68208791 A/G cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18552940 chr12:109490386 USP30 -0.43 -6.08 -0.32 3.24e-9 Electrocardiographic conduction measures; LUSC cis rs1865760 0.928 rs9295673 chr6:25912094 T/G cg16482183 chr6:26056742 HIST1H1C 0.45 6.8 0.35 4.91e-11 Height; LUSC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg06713675 chr4:122721982 EXOSC9 -0.44 -7.77 -0.39 9.93e-14 Type 2 diabetes; LUSC cis rs3741151 0.686 rs11822984 chr11:73261467 A/C cg17517138 chr11:73019481 ARHGEF17 0.92 7.8 0.39 8.22e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9905704 0.918 rs304282 chr17:56785571 T/C cg12560992 chr17:57184187 TRIM37 0.56 8.01 0.4 1.92e-14 Testicular germ cell tumor; LUSC cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg01065977 chr19:18549689 ISYNA1 -0.23 -5.89 -0.31 9.22e-9 Breast cancer; LUSC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.64 0.63 8.06e-38 Allergic disease (asthma, hay fever or eczema); LUSC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg08680598 chr22:49984980 NA -0.34 -6.25 -0.32 1.24e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.3 0.53 2.75e-25 Menopause (age at onset); LUSC cis rs6942756 0.806 rs6967464 chr7:128909727 T/C cg02491457 chr7:128862824 NA 0.48 7.23 0.37 3.26e-12 White matter hyperintensity burden; LUSC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg14004847 chr7:1930337 MAD1L1 -0.49 -7.52 -0.38 5.22e-13 Bipolar disorder and schizophrenia; LUSC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg25554036 chr4:6271136 WFS1 0.59 11.98 0.55 9.34e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2463822 0.583 rs7129536 chr11:62030829 C/T cg06239285 chr11:62104954 ASRGL1 -0.59 -6.01 -0.31 4.85e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg07148914 chr20:33460835 GGT7 -0.53 -8.1 -0.41 1.05e-14 Glomerular filtration rate (creatinine); LUSC trans rs1005277 0.540 rs1987431 chr10:37988887 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -6.48 -0.33 3.28e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2219968 0.746 rs10957878 chr8:78910939 A/C cg00738934 chr8:78996279 NA -0.4 -7.22 -0.37 3.45e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs12310956 0.532 rs11052952 chr12:33988048 G/A cg06521331 chr12:34319734 NA -0.46 -7.33 -0.37 1.72e-12 Morning vs. evening chronotype; LUSC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg05738196 chr6:26577821 NA -0.61 -7.05 -0.36 1.06e-11 Intelligence (multi-trait analysis); LUSC cis rs6542838 0.641 rs6542841 chr2:99489039 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.09 -0.32 3.1e-9 Fear of minor pain; LUSC cis rs68170813 0.562 rs78181351 chr7:106999301 A/G cg02696742 chr7:106810147 HBP1 -0.63 -9.36 -0.46 1.24e-18 Coronary artery disease; LUSC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.35 0.46 1.28e-18 Monocyte percentage of white cells; LUSC cis rs1865760 0.568 rs2032450 chr6:25993114 C/G cg16482183 chr6:26056742 HIST1H1C 0.47 6.88 0.35 2.95e-11 Height; LUSC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.77 0.54 5.5e-27 Hip circumference adjusted for BMI; LUSC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs6686643 0.630 rs7554034 chr1:165610464 G/A cg16553119 chr1:165599451 MGST3 -0.44 -5.84 -0.3 1.23e-8 Total ventricular volume; LUSC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg09034736 chr1:150693464 HORMAD1 0.51 7.45 0.38 8.22e-13 Urate levels; LUSC cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC trans rs11098499 0.908 rs11729050 chr4:120300066 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC trans rs56176327 0.583 rs7613603 chr3:49812866 C/T cg21659725 chr3:3221576 CRBN 0.68 8.24 0.41 3.83e-15 Intelligence (multi-trait analysis); LUSC cis rs60154123 0.730 rs10863818 chr1:210458007 C/T cg22029157 chr1:209979665 IRF6 0.51 5.84 0.3 1.23e-8 Coronary artery disease; LUSC cis rs11122272 0.735 rs2486745 chr1:231505717 T/C cg06096015 chr1:231504339 EGLN1 0.57 9.97 0.48 1.17e-20 Hemoglobin concentration; LUSC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 9.73e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6426558 0.559 rs485234 chr1:227317747 A/G cg10327440 chr1:227177885 CDC42BPA 0.55 7.41 0.38 1.02e-12 Neutrophil percentage of white cells; LUSC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.07 0.48 5.24e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15604682 chr7:102105781 ALKBH4;LRWD1 0.51 8.33 0.41 2.16e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2797160 1.000 rs6904069 chr6:125995134 C/T cg05901451 chr6:126070800 HEY2 -0.57 -8.75 -0.43 1.11e-16 Endometrial cancer; LUSC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg13939156 chr17:80058883 NA -0.33 -6.55 -0.34 2.23e-10 Life satisfaction; LUSC cis rs17767294 0.708 rs9380018 chr6:27740646 A/G cg08851530 chr6:28072375 NA 1.03 7.2 0.37 3.99e-12 Parkinson's disease; LUSC cis rs73206853 0.563 rs55885633 chr12:111189251 C/T cg12870014 chr12:110450643 ANKRD13A 0.66 6.54 0.34 2.34e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2303282 0.664 rs2440468 chr16:56420594 G/A cg00500540 chr16:56394104 NA -0.39 -6.67 -0.34 1.09e-10 Breast cancer; LUSC cis rs2710642 0.927 rs2539980 chr2:63208460 T/C cg17519650 chr2:63277830 OTX1 0.6 8.34 0.42 1.94e-15 LDL cholesterol levels;LDL cholesterol; LUSC cis rs1550582 1.000 rs1550582 chr8:135542084 A/G cg17885191 chr8:135476712 NA -0.66 -9.17 -0.45 4.81e-18 Educational attainment; LUSC cis rs9902453 0.934 rs8079028 chr17:28484234 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.84 0.44 5.47e-17 Coffee consumption (cups per day); LUSC cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg07148914 chr20:33460835 GGT7 -0.45 -6.59 -0.34 1.67e-10 Height; LUSC cis rs9814567 0.806 rs11927540 chr3:134319455 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.42 -0.56 2.29e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1847202 0.793 rs11918132 chr3:72952144 C/T cg25664220 chr3:72788482 NA -0.44 -7.94 -0.4 3.01e-14 Motion sickness; LUSC cis rs62400317 0.859 rs11965520 chr6:45259431 T/A cg18551225 chr6:44695536 NA -0.42 -7.01 -0.36 1.33e-11 Total body bone mineral density; LUSC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg09455208 chr3:40491958 NA 0.53 9.3 0.45 1.91e-18 Renal cell carcinoma; LUSC cis rs1775715 0.737 rs2778661 chr10:32159191 C/T cg26784012 chr10:32216390 ARHGAP12 0.46 7.87 0.4 4.88e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs13242816 1.000 rs36011826 chr7:116118336 G/A cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg11632617 chr15:75315747 PPCDC -0.52 -6.76 -0.35 6.32e-11 Blood trace element (Zn levels); LUSC trans rs6952808 0.609 rs12699453 chr7:1953056 C/T cg04565464 chr8:145669602 NFKBIL2 0.38 6.35 0.33 7.15e-10 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg04518342 chr5:131593106 PDLIM4 0.43 7.7 0.39 1.6e-13 Breast cancer; LUSC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg08677398 chr8:58056175 NA 0.53 6.36 0.33 6.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs9660992 0.710 rs55671824 chr1:205249814 G/A cg00857998 chr1:205179979 DSTYK 0.6 9.1 0.45 8.62e-18 Mean corpuscular volume;Mean platelet volume; LUSC trans rs2262909 0.962 rs1526884 chr19:22303651 A/G cg05197062 chr11:11642011 GALNTL4 0.54 7.62 0.38 2.72e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg09904177 chr6:26538194 HMGN4 -0.5 -5.95 -0.31 6.62e-9 Intelligence (multi-trait analysis); LUSC cis rs11785693 0.862 rs62491168 chr8:4982290 A/T cg26367366 chr8:4980734 NA 0.81 9.55 0.46 2.81e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs644148 0.933 rs565819 chr19:44967714 A/G cg15540054 chr19:45004280 ZNF180 0.55 7.84 0.39 6.17e-14 Personality dimensions; LUSC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg26597838 chr10:835615 NA 0.98 13.48 0.59 2.19e-33 Eosinophil percentage of granulocytes; LUSC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg23791538 chr6:167370224 RNASET2 0.42 6.79 0.35 5.09e-11 Crohn's disease; LUSC trans rs6582630 0.519 rs11495376 chr12:38284957 A/C cg06521331 chr12:34319734 NA -0.4 -6.09 -0.32 3.07e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg24060327 chr5:131705240 SLC22A5 -0.39 -6.46 -0.33 3.63e-10 Blood metabolite levels; LUSC cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg26395211 chr5:140044315 WDR55 0.45 7.0 0.36 1.39e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs738322 0.640 rs738321 chr22:38568833 C/G cg25457927 chr22:38595422 NA -0.38 -7.67 -0.39 1.93e-13 Cutaneous nevi; LUSC trans rs7939886 0.920 rs12223067 chr11:55915420 C/A cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg26677194 chr12:130822605 PIWIL1 0.59 8.77 0.43 9.52e-17 Menopause (age at onset); LUSC trans rs208520 0.690 rs12202401 chr6:66760544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 16.76 0.68 3.52e-46 Exhaled nitric oxide output; LUSC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg14004847 chr7:1930337 MAD1L1 -0.46 -6.85 -0.35 3.66e-11 Bipolar disorder and schizophrenia; LUSC cis rs7809950 0.817 rs62483725 chr7:107201575 G/A cg23024343 chr7:107201750 COG5 -0.71 -10.26 -0.49 1.19e-21 Coronary artery disease; LUSC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.67 14.94 0.63 5.16e-39 Hemoglobin concentration; LUSC cis rs6674970 0.933 rs11204772 chr1:151056305 C/T cg03258749 chr1:151040405 MLLT11 -0.45 -6.76 -0.35 6.12e-11 Childhood ear infection; LUSC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg23283495 chr1:209979779 IRF6 -0.66 -8.39 -0.42 1.4e-15 Cleft lip with or without cleft palate; LUSC cis rs17401966 0.522 rs10492969 chr1:10286358 T/C cg17425144 chr1:10567563 PEX14 -0.34 -6.05 -0.31 3.83e-9 Hepatocellular carcinoma; LUSC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.5 -0.38 5.7e-13 Alzheimer's disease (late onset); LUSC cis rs35883536 0.551 rs6666607 chr1:101032368 A/G cg06223162 chr1:101003688 GPR88 -0.49 -9.1 -0.45 8.3e-18 Monocyte count; LUSC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 3.03e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg12560992 chr17:57184187 TRIM37 -0.83 -14.94 -0.63 5.1e-39 Intelligence (multi-trait analysis); LUSC cis rs1256061 0.564 rs1256043 chr14:64734282 A/G cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg14004847 chr7:1930337 MAD1L1 -0.56 -8.66 -0.43 2.04e-16 Schizophrenia; LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg13395646 chr4:1353034 KIAA1530 -0.63 -10.16 -0.49 2.66e-21 Obesity-related traits; LUSC trans rs4927850 1.000 rs7630875 chr3:195753766 A/G cg21051086 chr3:73046214 PPP4R2 -0.52 -7.83 -0.39 6.62e-14 Pancreatic cancer; LUSC cis rs897984 0.762 rs7204459 chr16:30984212 G/A cg02466173 chr16:30829666 NA 0.55 10.91 0.51 6.58e-24 Dementia with Lewy bodies; LUSC cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC trans rs10435719 0.773 rs7842810 chr8:11794163 A/G cg08975724 chr8:8085496 FLJ10661 0.48 6.95 0.36 1.87e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9341808 0.791 rs1324122 chr6:80946061 G/A cg08355045 chr6:80787529 NA 0.56 9.58 0.46 2.37e-19 Sitting height ratio; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03309838 chr22:41215494 SLC25A17 -0.41 -6.89 -0.35 2.74e-11 Electrocardiographic conduction measures; LUSC trans rs1005277 0.579 rs932538 chr10:38381314 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.72 -0.47 8.18e-20 Extrinsic epigenetic age acceleration; LUSC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg03264133 chr6:25882463 NA -0.75 -12.42 -0.56 2.2e-29 Intelligence (multi-trait analysis); LUSC cis rs992157 0.735 rs12990082 chr2:219102332 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.51 8.03 0.4 1.68e-14 Colorectal cancer; LUSC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.76e-13 Schizophrenia; LUSC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg17971929 chr21:40555470 PSMG1 -0.53 -7.75 -0.39 1.15e-13 Menarche (age at onset); LUSC cis rs968567 0.528 rs174582 chr11:61607168 A/G cg06781209 chr11:61594997 FADS2 -0.44 -6.56 -0.34 2.09e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs11039100 0.920 rs12792905 chr11:5821544 G/C cg05234568 chr11:5960015 NA -0.51 -5.76 -0.3 1.87e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1595825 0.891 rs996427 chr2:198685609 G/A cg00982548 chr2:198649783 BOLL -0.59 -7.27 -0.37 2.62e-12 Ulcerative colitis; LUSC cis rs593982 0.777 rs534414 chr11:65475515 A/G cg08755490 chr11:65554678 OVOL1 1.53 13.68 0.6 3.88e-34 Atopic dermatitis; LUSC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg24829409 chr8:58192753 C8orf71 -0.61 -6.44 -0.33 4.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs2346177 0.519 rs35509718 chr2:46696793 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.59 -9.33 -0.45 1.57e-18 HDL cholesterol; LUSC trans rs9929218 1.000 rs12446575 chr16:68791644 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -12.48 -0.56 1.37e-29 Colorectal cancer; LUSC cis rs9608946 0.515 rs3804078 chr22:30853882 T/C cg03868770 chr22:30783737 RNF215 -0.34 -5.67 -0.3 3.17e-8 Red cell distribution width; LUSC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg23093090 chr10:104574429 C10orf26 -0.37 -6.84 -0.35 3.81e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12541635 0.833 rs4734130 chr8:107096458 A/G cg10147462 chr8:107024639 NA -0.43 -7.56 -0.38 4.01e-13 Age of smoking initiation; LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.05 -0.31 3.93e-9 Platelet count; LUSC cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg12615879 chr12:58013172 SLC26A10 -0.26 -5.88 -0.31 9.8e-9 Multiple sclerosis; LUSC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg12463550 chr7:65579703 CRCP 0.51 7.38 0.37 1.26e-12 Aortic root size; LUSC cis rs36093844 0.800 rs1445504 chr11:85584879 G/A cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs4566357 1.000 rs2141829 chr2:227922454 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.91 -0.31 8.3e-9 Coronary artery disease; LUSC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7681440 0.647 rs11941110 chr4:90819569 T/C cg01966878 chr4:90757139 SNCA -0.35 -5.67 -0.3 3.15e-8 Dementia with Lewy bodies; LUSC cis rs4803468 1.000 rs55986560 chr19:41939835 C/T cg09537434 chr19:41945824 ATP5SL 0.96 16.32 0.67 1.86e-44 Height; LUSC cis rs4253772 0.744 rs9627278 chr22:46643432 C/G cg24881330 chr22:46731750 TRMU 0.57 6.53 0.34 2.46e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs77633900 0.614 rs280012 chr15:76974854 G/T cg21673338 chr15:77095150 SCAPER -0.8 -8.15 -0.41 7.48e-15 Non-glioblastoma glioma;Glioma; LUSC cis rs12586317 0.534 rs1568200 chr14:35419592 C/T cg05294307 chr14:35346193 BAZ1A -0.51 -6.34 -0.33 7.49e-10 Psoriasis; LUSC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg13683864 chr3:40499215 RPL14 -1.11 -18.36 -0.71 1.5e-52 Renal cell carcinoma; LUSC cis rs66887589 0.967 rs1480933 chr4:120433248 C/T cg09307838 chr4:120376055 NA 0.49 7.45 0.38 8.28e-13 Diastolic blood pressure; LUSC trans rs7824557 0.751 rs2099456 chr8:11127001 A/C cg08975724 chr8:8085496 FLJ10661 0.46 7.07 0.36 8.95e-12 Retinal vascular caliber; LUSC cis rs6582630 0.572 rs1969363 chr12:38514872 A/G cg13010199 chr12:38710504 ALG10B 0.49 7.53 0.38 4.89e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs8064299 0.597 rs4789098 chr17:72781292 C/G cg25054828 chr17:72772726 NAT9;TMEM104 0.91 18.0 0.7 4.29e-51 Monocyte count; LUSC cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg23029597 chr12:123009494 RSRC2 -0.72 -9.5 -0.46 4.17e-19 Body mass index; LUSC trans rs12200782 0.674 rs12207224 chr6:26519280 A/T cg11837749 chr1:55047332 ACOT11 0.58 6.31 0.33 8.85e-10 Small cell lung carcinoma; LUSC cis rs225245 0.817 rs1049379 chr17:33998802 G/C cg05299278 chr17:33885742 SLFN14 0.29 6.35 0.33 7.12e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs6596100 0.538 rs4705972 chr5:132179237 T/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.16 -0.32 2.14e-9 Breast cancer; LUSC cis rs11048434 0.736 rs7957321 chr12:9120154 C/T cg13575925 chr12:9217583 LOC144571 0.35 6.44 0.33 4.27e-10 Sjögren's syndrome; LUSC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.39e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9611565 0.694 rs11090056 chr22:42095904 A/C cg03806693 chr22:41940476 POLR3H 0.85 12.11 0.55 3.09e-28 Vitiligo; LUSC cis rs478304 0.530 rs11568300 chr11:65425167 C/G cg05805236 chr11:65401703 PCNXL3 -0.64 -10.71 -0.51 3.43e-23 Acne (severe); LUSC cis rs3125734 0.633 rs7088891 chr10:64034019 G/T cg09941381 chr10:64027924 RTKN2 -0.4 -7.21 -0.37 3.77e-12 Rheumatoid arthritis; LUSC cis rs4891159 0.790 rs8098821 chr18:74140345 T/C cg24786174 chr18:74118243 ZNF516 -0.84 -15.44 -0.65 5.61e-41 Longevity; LUSC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg24110177 chr3:50126178 RBM5 0.59 9.65 0.47 1.31e-19 Intelligence (multi-trait analysis); LUSC cis rs7568458 0.846 rs6705839 chr2:85761279 A/T cg23752985 chr2:85803571 VAMP8 0.29 6.22 0.32 1.52e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2667011 0.759 rs1567537 chr2:160857568 T/C cg06573604 chr2:160760825 LY75 -0.49 -6.23 -0.32 1.42e-9 Bilirubin levels; LUSC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.88e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9302065 0.681 rs9524903 chr13:95963565 A/G cg26751094 chr13:95954534 ABCC4 -0.43 -7.68 -0.39 1.77e-13 Blood metabolite levels; LUSC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg06108461 chr20:60628389 TAF4 -0.74 -11.88 -0.54 2.19e-27 Body mass index; LUSC cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg08085267 chr17:45401833 C17orf57 0.6 9.97 0.48 1.12e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg24920358 chr1:40204285 PPIE 0.6 10.61 0.5 7.42e-23 Blood protein levels; LUSC cis rs3806843 1.000 rs1030165 chr5:140185448 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.69 -0.3 2.8e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg10523679 chr1:76189770 ACADM 0.64 8.96 0.44 2.27e-17 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg10523679 chr1:76189770 ACADM -0.84 -11.24 -0.52 4.63e-25 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs330071 0.500 rs17662123 chr8:9246837 G/A cg21775007 chr8:11205619 TDH 0.44 6.44 0.33 4.27e-10 Acne (severe); LUSC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs62064224 0.905 rs9891969 chr17:30627085 C/T cg25809561 chr17:30822961 MYO1D 0.39 6.44 0.33 4.09e-10 Schizophrenia; LUSC cis rs240764 0.817 rs6907240 chr6:101153782 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.17 -0.32 2.03e-9 Neuroticism; LUSC cis rs8126001 0.626 rs4337532 chr20:62715089 G/A cg03642690 chr20:62727907 OPRL1 -0.32 -5.78 -0.3 1.68e-8 Pulse pressure;Mean corpuscular volume; LUSC trans rs4650994 0.544 rs6682815 chr1:178501109 T/C cg05059571 chr16:84539110 KIAA1609 -0.47 -9.1 -0.45 8.55e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs968451 0.547 rs11704319 chr22:39722886 A/G cg17798944 chr22:39715225 SNORD43;RPL3 -0.74 -12.1 -0.55 3.42e-28 Primary biliary cholangitis; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg07167872 chr1:205819463 PM20D1 -0.75 -14.67 -0.63 6.03e-38 Monocyte percentage of white cells; LUSC cis rs6598955 0.671 rs58038522 chr1:26582713 C/T cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs9302635 0.513 rs12928732 chr16:72188683 C/T cg01557791 chr16:72042693 DHODH -0.5 -6.43 -0.33 4.45e-10 Blood protein levels; LUSC cis rs714027 0.585 rs73162764 chr22:30358745 G/A cg11564601 chr22:30592435 NA 0.34 5.86 0.31 1.14e-8 Lymphocyte counts; LUSC cis rs4478858 0.746 rs10914328 chr1:31688406 A/G cg00250761 chr1:31883323 NA 0.36 9.23 0.45 3.3e-18 Alcohol dependence; LUSC cis rs11098499 0.657 rs4463052 chr4:120313258 T/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs11209002 0.956 rs11209000 chr1:67578514 C/G cg02640540 chr1:67518911 SLC35D1 0.69 7.58 0.38 3.42e-13 Crohn's disease; LUSC cis rs9341808 0.690 rs3805926 chr6:80879280 C/G cg08355045 chr6:80787529 NA 0.58 10.05 0.48 6.06e-21 Sitting height ratio; LUSC cis rs36093844 1.000 rs11234452 chr11:85576801 C/T cg25872744 chr11:85566296 CCDC83 -0.5 -7.76 -0.39 1.05e-13 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg08472276 chr7:1133186 C7orf50;GPER -0.41 -6.58 -0.34 1.81e-10 Longevity;Endometriosis; LUSC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.9e-11 Blood metabolite levels; LUSC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg25204440 chr1:209979598 IRF6 0.5 6.63 0.34 1.36e-10 Cleft lip with or without cleft palate; LUSC trans rs7939886 0.920 rs1482009 chr11:55884690 T/G cg03929089 chr4:120376271 NA 0.75 6.11 0.32 2.77e-9 Myopia (pathological); LUSC cis rs7106204 0.609 rs16912391 chr11:24310637 G/A ch.11.24196551F chr11:24239977 NA 0.69 5.68 0.3 2.86e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs41271473 0.526 rs942853 chr1:228730949 G/T cg16512390 chr1:228756714 NA 0.7 8.89 0.44 4.03e-17 Chronic lymphocytic leukemia; LUSC cis rs6964587 1.000 rs926192 chr7:91671853 C/A cg17063962 chr7:91808500 NA 0.57 9.09 0.45 8.73e-18 Breast cancer; LUSC cis rs11864453 0.826 rs2074626 chr16:72139184 C/A cg16558253 chr16:72132732 DHX38 -0.42 -6.41 -0.33 5e-10 Fibrinogen levels; LUSC cis rs6456156 0.565 rs2181058 chr6:167465330 A/T cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC cis rs4555082 1.000 rs4334224 chr14:105759198 C/T cg10792982 chr14:105748885 BRF1 0.46 8.16 0.41 6.69e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.33e-32 Chronic sinus infection; LUSC cis rs2282802 0.651 rs13353827 chr5:139654537 T/C cg26211634 chr5:139558579 C5orf32 0.44 8.34 0.41 2.04e-15 Intelligence (multi-trait analysis); LUSC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg09323728 chr8:95962352 TP53INP1 -0.45 -9.45 -0.46 6.1e-19 Type 2 diabetes; LUSC cis rs7267979 1.000 rs2258884 chr20:25279539 C/T cg08601574 chr20:25228251 PYGB 0.43 6.55 0.34 2.15e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3806843 0.966 rs10036519 chr5:140151701 C/T cg26395211 chr5:140044315 WDR55 0.41 6.41 0.33 5.09e-10 Depressive symptoms (multi-trait analysis); LUSC cis rs17539620 0.624 rs62432739 chr6:154835926 A/G cg20019720 chr6:154832845 CNKSR3 0.62 8.69 0.43 1.63e-16 Lipoprotein (a) levels; LUSC cis rs886126 1.000 rs4766451 chr12:111670682 G/T cg10833066 chr12:111807467 FAM109A 0.4 6.45 0.33 4.02e-10 Coronary heart disease; LUSC cis rs4704187 0.687 rs9654429 chr5:74466925 C/G cg03227963 chr5:74354835 NA 0.31 6.7 0.34 8.62e-11 Response to amphetamines; LUSC cis rs9400467 0.528 rs7750792 chr6:111783759 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.46 -0.33 3.79e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs10782582 0.532 rs12132503 chr1:76137762 C/G cg03433033 chr1:76189801 ACADM -0.46 -6.92 -0.35 2.27e-11 Daytime sleep phenotypes; LUSC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg06484146 chr7:12443880 VWDE -0.67 -6.99 -0.36 1.51e-11 Coronary artery disease; LUSC cis rs7202877 0.706 rs247447 chr16:75486648 A/G cg04384234 chr16:75411784 CFDP1 0.63 8.34 0.42 2e-15 Type 2 diabetes;Type 1 diabetes; LUSC cis rs1003719 0.715 rs1981433 chr21:38542223 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10139443 chr6:99963249 USP45 -0.38 -6.09 -0.32 3.05e-9 Electrocardiographic conduction measures; LUSC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg15691649 chr6:25882328 NA -0.4 -5.74 -0.3 2.18e-8 Intelligence (multi-trait analysis); LUSC cis rs7943203 0.525 rs665293 chr11:108142617 G/A cg04873221 chr11:107992290 ACAT1 -0.4 -5.87 -0.31 1.06e-8 Red blood cell count;Mean corpuscular volume; LUSC cis rs8038465 0.615 rs6495076 chr15:73982965 G/A cg15420318 chr15:73925796 NPTN 0.56 9.47 0.46 5.15e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs55871839 0.708 rs7000535 chr8:59804351 T/C cg07426533 chr8:59803705 TOX -0.36 -5.81 -0.3 1.44e-8 Pneumonia; LUSC cis rs9300255 0.537 rs1619561 chr12:123620268 G/C cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.16 -0.32 2.09e-9 Neutrophil percentage of white cells; LUSC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs68170813 0.559 rs76208112 chr7:106964222 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.62 -0.47 1.71e-19 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20471045 chr19:49568214 NTF4 -0.55 -7.58 -0.38 3.36e-13 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg10802521 chr3:52805072 NEK4 -0.56 -8.78 -0.43 8.37e-17 Bipolar disorder; LUSC cis rs7666738 0.546 rs9993299 chr4:98815976 G/A cg03676636 chr4:99064102 C4orf37 0.32 6.05 0.31 3.8e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.709 rs11072591 chr15:76649562 A/G cg23625390 chr15:77176239 SCAPER 0.59 9.36 0.46 1.25e-18 Blood metabolite levels; LUSC cis rs6542838 0.597 rs35107109 chr2:99386210 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.46 -5.9 -0.31 9.11e-9 Fear of minor pain; LUSC cis rs921665 0.749 rs4854133 chr2:3199626 C/T cg16434511 chr2:3151078 NA -0.61 -6.49 -0.33 3.11e-10 World class endurance athleticism; LUSC cis rs1670533 1.000 rs11247971 chr4:1053580 A/G cg02018176 chr4:1364513 KIAA1530 0.43 6.15 0.32 2.24e-9 Recombination rate (females); LUSC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg23649088 chr2:200775458 C2orf69 0.54 7.35 0.37 1.58e-12 Schizophrenia; LUSC cis rs8014204 0.901 rs2080087 chr14:75365062 C/T cg06637938 chr14:75390232 RPS6KL1 0.67 11.26 0.52 3.78e-25 Caffeine consumption; LUSC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.8 -0.35 4.92e-11 Lung cancer; LUSC cis rs7617773 0.817 rs936426 chr3:48215253 C/T cg20734569 chr3:48348370 SPINK8 -0.47 -8.34 -0.42 1.93e-15 Coronary artery disease; LUSC cis rs6693567 0.874 rs698915 chr1:150388318 C/T cg15654264 chr1:150340011 RPRD2 -0.43 -6.08 -0.32 3.3e-9 Migraine; LUSC cis rs7954584 0.567 rs11043243 chr12:122356370 G/C cg21016266 chr12:122356598 WDR66 0.61 9.04 0.44 1.33e-17 Mean corpuscular volume; LUSC cis rs7814319 0.840 rs10504961 chr8:97240129 C/T cg20787634 chr8:97240163 UQCRB -0.34 -5.92 -0.31 7.92e-9 Lung function (FVC); LUSC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.79e-9 Vitiligo; LUSC cis rs3540 0.533 rs2256110 chr15:90971036 T/C cg10434728 chr15:90938212 IQGAP1 0.41 8.61 0.43 2.89e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs11098499 0.588 rs6534149 chr4:120559292 T/G cg25214090 chr10:38739885 LOC399744 -0.41 -6.43 -0.33 4.44e-10 Corneal astigmatism; LUSC cis rs2624839 0.704 rs12632110 chr3:50224225 A/G cg14019146 chr3:50243930 SLC38A3 0.48 11.43 0.53 9.38e-26 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.21 0.59 2.51e-32 Cognitive test performance; LUSC cis rs2304069 0.644 rs216131 chr5:149431223 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.51 6.62 0.34 1.44e-10 HIV-1 control; LUSC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs9399401 0.710 rs6900087 chr6:142717303 A/T cg03128060 chr6:142623767 GPR126 0.57 9.48 0.46 4.8e-19 Chronic obstructive pulmonary disease; LUSC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg19046167 chr17:80928561 B3GNTL1 0.44 7.17 0.37 4.89e-12 Breast cancer; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg01774158 chr5:133562094 PPP2CA -0.35 -6.38 -0.33 6e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs3857536 0.813 rs7768944 chr6:66951088 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC trans rs4729127 1.000 rs17166206 chr7:94004197 C/T cg14660007 chr13:78271894 SLAIN1 0.49 6.22 0.32 1.52e-9 Intelligence; LUSC cis rs501916 0.833 rs3809486 chr15:48051549 G/T cg16110827 chr15:48056943 SEMA6D -0.47 -7.28 -0.37 2.35e-12 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg11752832 chr7:134001865 SLC35B4 0.51 7.36 0.37 1.47e-12 Mean platelet volume; LUSC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg22535103 chr8:58192502 C8orf71 -0.55 -6.65 -0.34 1.19e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs151234 0.612 rs11641853 chr16:28589719 A/G cg01378222 chr16:28622494 SULT1A1 -0.63 -8.53 -0.42 5.08e-16 Platelet distribution width; LUSC trans rs7618501 0.602 rs2526743 chr3:50115245 G/A cg21659725 chr3:3221576 CRBN -0.64 -10.55 -0.5 1.17e-22 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20263435 chr8:41435469 AGPAT6 -0.4 -6.01 -0.31 4.97e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1995809 0.793 rs76475338 chr4:147758842 C/A cg04587220 chr19:1071208 HMHA1 0.54 6.03 0.31 4.27e-9 Plasma amyloid beta peptide concentrations (ABx-40); LUSC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg13902645 chr11:5959945 NA -0.59 -8.28 -0.41 2.95e-15 DNA methylation (variation); LUSC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.01 0.58 1.44e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8078723 1.000 rs3826331 chr17:38150492 T/C cg17467752 chr17:38218738 THRA -0.77 -12.38 -0.56 3.22e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg23711669 chr6:146136114 FBXO30 0.91 17.74 0.7 4.59e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs7091957 1.000 rs7091957 chr10:134439478 C/T cg26818010 chr10:134567672 INPP5A -0.43 -6.5 -0.34 2.88e-10 Gait speed in old age; LUSC cis rs9395066 0.545 rs10948197 chr6:44967490 C/T cg25276700 chr6:44698697 NA -0.27 -5.65 -0.3 3.46e-8 Height; LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg26314531 chr2:26401878 FAM59B 0.72 10.0 0.48 9.4499999999999992e-21 Gut microbiome composition (summer); LUSC cis rs4654899 0.865 rs61779120 chr1:21481230 T/C cg01072550 chr1:21505969 NA -0.53 -7.81 -0.39 7.38e-14 Superior frontal gyrus grey matter volume; LUSC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg08742575 chr21:47604166 C21orf56 -0.42 -6.26 -0.32 1.2e-9 Testicular germ cell tumor; LUSC cis rs4363385 0.747 rs6668696 chr1:152964910 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.56 -0.38 3.85e-13 Inflammatory skin disease; LUSC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg24324837 chr19:49891574 CCDC155 0.49 6.25 0.32 1.23e-9 Multiple sclerosis; LUSC cis rs3768617 0.677 rs12739316 chr1:183052080 G/A ch.1.3577855R chr1:183094577 LAMC1 0.6 8.63 0.43 2.61e-16 Fuchs's corneal dystrophy; LUSC cis rs6964587 0.692 rs2027950 chr7:91863700 C/G cg17063962 chr7:91808500 NA -0.62 -10.42 -0.5 3.35e-22 Breast cancer; LUSC cis rs2729354 0.817 rs2649667 chr11:57270509 A/C cg24343310 chr11:57249947 NA 0.46 9.01 0.44 1.67e-17 Blood protein levels; LUSC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg26597838 chr10:835615 NA 1.01 14.27 0.62 2.06e-36 Eosinophil percentage of granulocytes; LUSC trans rs12145833 0.538 rs10754798 chr1:243309958 A/G cg01826367 chr1:224180288 NA -0.68 -6.61 -0.34 1.54e-10 Obesity (early onset extreme); LUSC cis rs709400 0.628 rs1989565 chr14:103862193 G/A cg12935359 chr14:103987150 CKB 0.54 8.47 0.42 7.69e-16 Body mass index; LUSC cis rs7582720 0.943 rs72932560 chr2:203847417 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.35 0.42 1.88e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1113500 0.730 rs1777457 chr1:108588195 G/T cg06207961 chr1:108661230 NA -0.31 -5.88 -0.31 9.84e-9 Growth-regulated protein alpha levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20400718 chr8:42940792 FNTA 0.49 6.14 0.32 2.33e-9 Bipolar disorder and schizophrenia; LUSC cis rs17102423 0.652 rs4902361 chr14:65548470 G/T cg11161011 chr14:65562177 MAX -0.74 -11.59 -0.54 2.37e-26 Obesity-related traits; LUSC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs10779751 0.762 rs6540965 chr1:11325521 C/G cg08854313 chr1:11322531 MTOR -0.68 -11.73 -0.54 7.75e-27 Body mass index; LUSC cis rs6845621 0.727 rs4434248 chr4:18905576 C/T cg12196642 chr4:18937545 NA 0.33 6.28 0.32 1.06e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2798269 0.966 rs11148158 chr13:22137743 C/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.04 -0.31 4.15e-9 PR segment; LUSC cis rs9314323 0.767 rs1865305 chr8:26233325 G/A cg13160058 chr8:26243215 BNIP3L -0.43 -7.61 -0.38 2.76e-13 Red cell distribution width; LUSC cis rs11758351 0.866 rs77205516 chr6:26205356 T/A cg01420254 chr6:26195488 NA 0.68 7.52 0.38 5.21e-13 Gout;Renal underexcretion gout; LUSC cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.47 -7.09 -0.36 7.97e-12 Colorectal cancer; LUSC cis rs11714574 0.557 rs6787467 chr3:58377888 G/A cg13750441 chr3:58318267 PXK -0.3 -5.85 -0.3 1.16e-8 Response to abacavir-containing treatment in HIV-1 infection (virologic failure); LUSC cis rs983392 0.591 rs3132886 chr11:60016387 T/A cg02771260 chr11:59836817 MS4A3 0.38 6.16 0.32 2.14e-9 Alzheimer's disease (late onset); LUSC cis rs9649465 0.561 rs688242 chr7:123420442 C/A cg03229431 chr7:123269106 ASB15 0.48 7.79 0.39 8.83e-14 Migraine; LUSC cis rs1559088 0.847 rs3786933 chr19:33602881 C/T cg03563238 chr19:33554763 RHPN2 -0.4 -6.43 -0.33 4.3e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg20406979 chr6:167373233 NA 0.27 6.34 0.33 7.5e-10 Crohn's disease; LUSC trans rs2011013 0.957 rs61378395 chr15:84607934 A/G cg17006413 chr1:942451 NA 0.26 6.01 0.31 4.74e-9 Sitting height ratio; LUSC cis rs4561483 0.831 rs2075158 chr16:11945231 T/C cg08843971 chr16:11963173 GSPT1 0.45 6.36 0.33 6.73e-10 Testicular germ cell tumor; LUSC trans rs2729385 1.000 rs2729385 chr11:57262993 C/T cg20818191 chr4:866154 GAK -0.46 -6.2 -0.32 1.63e-9 Interleukin-18 levels; LUSC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Vitiligo; LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg04775059 chr7:64541387 NA 0.48 7.03 0.36 1.2e-11 Calcium levels; LUSC trans rs6952808 0.689 rs12668156 chr7:2019875 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.14 0.32 2.28e-9 Bipolar disorder and schizophrenia; LUSC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg06238570 chr21:40685208 BRWD1 0.48 7.41 0.38 1.05e-12 Cognitive function; LUSC cis rs11190604 1.000 rs1080698 chr10:102295114 G/T cg16342193 chr10:102329863 NA -0.36 -6.56 -0.34 2.02e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.94 0.66 5.94e-43 Platelet count; LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg00149659 chr3:10157352 C3orf10 0.98 14.52 0.62 2.16e-37 Alzheimer's disease; LUSC trans rs2363709 0.881 rs17805405 chr3:67361963 A/G cg23062198 chr2:14774063 FAM84A 0.56 6.09 0.32 3.09e-9 IgE levels; LUSC trans rs7647973 0.626 rs9824435 chr3:49674343 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.61 7.36 0.37 1.43e-12 Menarche (age at onset); LUSC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg18252515 chr7:66147081 NA -1.18 -13.0 -0.58 1.52e-31 Diabetic kidney disease; LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg24846343 chr22:24311635 DDTL 0.66 14.02 0.61 2.03e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9815354 0.680 rs73073301 chr3:42028777 T/C cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg09365446 chr1:150670422 GOLPH3L 0.51 8.06 0.4 1.39e-14 Tonsillectomy; LUSC cis rs2370759 1.000 rs11599522 chr10:32568434 G/C cg01819863 chr10:32635814 EPC1 1.06 13.3 0.59 1.06e-32 Sexual dysfunction (female); LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg08888203 chr3:10149979 C3orf24 0.59 8.11 0.41 9.88e-15 Alzheimer's disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg22927510 chr22:50968328 TYMP 0.42 6.05 0.31 3.93e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.51 -0.53 4.8e-26 Mean corpuscular volume; LUSC cis rs11190604 0.767 rs10883479 chr10:102162860 A/G cg07080220 chr10:102295463 HIF1AN 0.59 7.67 0.39 1.94e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg16586182 chr3:47516702 SCAP -0.52 -7.43 -0.38 9.45e-13 Birth weight; LUSC cis rs1908814 0.516 rs13275143 chr8:11796990 T/A cg21775007 chr8:11205619 TDH 0.46 6.46 0.33 3.63e-10 Neuroticism; LUSC cis rs9560113 0.580 rs9560116 chr13:112193731 G/A cg10483660 chr13:112241077 NA 0.38 6.85 0.35 3.46e-11 Menarche (age at onset); LUSC cis rs3815700 1.000 rs2287670 chr19:33095057 G/A cg02997394 chr19:33096574 ANKRD27 0.79 8.95 0.44 2.49e-17 Eosinophilic esophagitis; LUSC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg01283332 chr5:1856932 NA -0.32 -5.98 -0.31 5.75e-9 Cardiovascular disease risk factors; LUSC trans rs2243480 1.000 rs313807 chr7:65499481 C/T cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.58e-15 Diabetic kidney disease; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -6.46 -0.33 3.73e-10 Longevity;Endometriosis; LUSC cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg24642439 chr20:33292090 TP53INP2 0.51 7.63 0.39 2.51e-13 Height; LUSC cis rs7927592 0.913 rs7115374 chr11:68300076 G/T cg20283391 chr11:68216788 NA -0.61 -8.57 -0.42 3.81e-16 Total body bone mineral density; LUSC cis rs713477 0.967 rs8009706 chr14:55914756 A/G cg13175173 chr14:55914753 NA -0.3 -6.4 -0.33 5.2e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg03264133 chr6:25882463 NA -0.5 -9.11 -0.45 7.57e-18 Blood metabolite levels; LUSC cis rs68170813 0.559 rs59782202 chr7:107032766 G/T cg02696742 chr7:106810147 HBP1 -0.61 -8.98 -0.44 1.96e-17 Coronary artery disease; LUSC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg03929089 chr4:120376271 NA -1.04 -20.32 -0.74 2.46e-60 Height; LUSC trans rs61931739 0.500 rs11053210 chr12:34461771 A/G cg26384229 chr12:38710491 ALG10B -0.82 -13.39 -0.59 5.12e-33 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03911494 chr16:71660463 MARVELD3 -0.5 -6.11 -0.32 2.74e-9 Bipolar disorder and schizophrenia; LUSC cis rs17102423 0.594 rs942628 chr14:65539463 C/G cg11161011 chr14:65562177 MAX -0.69 -10.81 -0.51 1.53e-23 Obesity-related traits; LUSC cis rs11587682 0.760 rs7542068 chr1:150463772 C/G cg11822372 chr1:151115635 SEMA6C 0.42 5.67 0.3 3.13e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.73 -0.3 2.25e-8 Depression; LUSC cis rs7512552 0.839 rs2794684 chr1:150320571 C/T cg15654264 chr1:150340011 RPRD2 0.69 11.59 0.54 2.51e-26 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs7568458 0.709 rs11895399 chr2:85753806 C/A cg02493740 chr2:85810744 VAMP5 -0.49 -8.62 -0.43 2.68e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7178572 1.000 rs62007299 chr15:77711719 G/A cg22256960 chr15:77711686 NA -0.54 -9.11 -0.45 7.85e-18 Type 2 diabetes; LUSC cis rs1348850 0.645 rs13431091 chr2:178434615 A/G cg23306229 chr2:178417860 TTC30B 0.55 6.13 0.32 2.52e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7560272 0.723 rs6743576 chr2:73814333 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -7.41 -0.38 1.02e-12 Schizophrenia; LUSC cis rs611744 0.647 rs2597658 chr8:109256014 C/T cg21045802 chr8:109455806 TTC35 0.43 6.66 0.34 1.13e-10 Dupuytren's disease; LUSC cis rs9660992 0.700 rs7547565 chr1:205259402 G/A cg00857998 chr1:205179979 DSTYK -0.55 -8.5 -0.42 6.44e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10752881 0.935 rs4652771 chr1:183023503 G/A ch.1.3577855R chr1:183094577 LAMC1 0.7 10.89 0.51 7.63e-24 Colorectal cancer; LUSC cis rs13385 0.769 rs12717954 chr5:139595299 C/T cg26211634 chr5:139558579 C5orf32 0.45 6.73 0.35 7.44e-11 Atrial fibrillation; LUSC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg20203395 chr5:56204925 C5orf35 -0.45 -6.77 -0.35 5.92e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs7267979 0.966 rs6083818 chr20:25346082 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08170757 chr19:48867271 TMEM143;SYNGR4 -0.44 -6.4 -0.33 5.13e-10 Electrocardiographic conduction measures; LUSC cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg21918786 chr6:109611834 NA -0.38 -6.45 -0.33 3.86e-10 Reticulocyte fraction of red cells; LUSC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg18479299 chr3:125709523 NA -0.51 -5.83 -0.3 1.33e-8 Blood pressure (smoking interaction); LUSC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg07936489 chr17:37558343 FBXL20 -0.72 -10.11 -0.48 3.96e-21 Glomerular filtration rate (creatinine); LUSC cis rs4964805 0.626 rs11111767 chr12:104176246 A/G cg02344784 chr12:104178138 NT5DC3 -0.43 -7.01 -0.36 1.34e-11 Attention deficit hyperactivity disorder; LUSC cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.88 -0.4 4.8e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs926938 0.563 rs360586 chr1:115467489 A/G cg12756093 chr1:115239321 AMPD1 0.44 6.5 0.34 2.96e-10 Autism; LUSC cis rs131777 0.575 rs131760 chr22:51011936 T/C cg00083937 chr22:51039805 MAPK8IP2 0.52 8.8 0.43 7.39e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs394563 0.810 rs480870 chr6:149784818 T/C cg16235748 chr6:149772707 ZC3H12D -0.32 -6.39 -0.33 5.66e-10 Dupuytren's disease; LUSC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.69 -12.28 -0.56 7.17e-29 Personality dimensions; LUSC cis rs2637266 1.000 rs7476937 chr10:78357692 A/T cg18941641 chr10:78392320 NA 0.39 7.0 0.36 1.4e-11 Pulmonary function; LUSC trans rs7044246 0.889 rs9411433 chr9:134921485 C/T cg03562770 chr12:39538604 NA -0.36 -6.29 -0.33 1.01e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg17366294 chr4:99064904 C4orf37 0.5 8.17 0.41 6.33e-15 Colonoscopy-negative controls vs population controls; LUSC trans rs3733585 0.699 rs6449176 chr4:9967843 G/A cg26043149 chr18:55253948 FECH -0.46 -7.09 -0.36 7.93e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC trans rs6089829 0.926 rs6011552 chr20:61667894 T/C cg17470723 chr8:74884337 TCEB1 0.52 7.94 0.4 3.05e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1372520 0.748 rs990085 chr4:90754771 A/G cg01966878 chr4:90757139 SNCA -0.42 -6.0 -0.31 5.18e-9 Neuroticism; LUSC cis rs9640161 0.830 rs3757425 chr7:150067640 A/C cg21361702 chr7:150065534 REPIN1 0.58 9.16 0.45 5.54e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs11098499 0.697 rs10016448 chr4:120298845 A/G cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg03806693 chr22:41940476 POLR3H -1.06 -15.56 -0.65 1.88e-41 Vitiligo; LUSC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg26818010 chr10:134567672 INPP5A -0.78 -10.48 -0.5 2.04e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.59 -0.57 5.17e-30 Platelet count; LUSC cis rs6669072 0.565 rs1997155 chr1:91265543 G/T cg08895590 chr1:91227319 NA -0.27 -5.84 -0.3 1.21e-8 Cognitive function; LUSC cis rs12421382 0.593 rs2357793 chr11:109389353 A/T cg16359550 chr11:109292809 C11orf87 0.34 5.99 0.31 5.43e-9 Schizophrenia; LUSC cis rs9837602 1.000 rs62285462 chr3:99769834 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -5.97 -0.31 6.22e-9 Breast cancer; LUSC cis rs4478858 0.735 rs1566961 chr1:31772450 G/A cg00250761 chr1:31883323 NA -0.34 -8.46 -0.42 8.39e-16 Alcohol dependence; LUSC trans rs2797160 0.935 rs6940748 chr6:125994080 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.54 -0.34 2.36e-10 Endometrial cancer; LUSC cis rs12928939 0.774 rs7192860 chr16:71643622 G/A cg03805757 chr16:71968109 PKD1L3 -0.43 -6.25 -0.32 1.23e-9 Post bronchodilator FEV1; LUSC cis rs8017423 0.967 rs11621431 chr14:90709221 C/T cg14092571 chr14:90743983 NA -0.35 -5.67 -0.3 3.12e-8 Mortality in heart failure; LUSC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15506890 chr2:3487001 NA 0.56 9.28 0.45 2.13e-18 Neurofibrillary tangles; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg10518340 chr6:97731094 MIR548H3;C6orf167 -0.42 -6.05 -0.31 3.97e-9 Electrocardiographic conduction measures; LUSC trans rs8040855 1.000 rs6496768 chr15:85702932 A/G cg00988175 chr11:59481031 OR10V1 -0.29 -6.21 -0.32 1.53e-9 Bulimia nervosa; LUSC cis rs1728785 1.000 rs698717 chr16:68560199 A/G cg02972257 chr16:68554789 NA -0.5 -6.35 -0.33 7.04e-10 Ulcerative colitis; LUSC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg02079420 chr8:82753780 SNX16 0.43 7.37 0.37 1.39e-12 Diastolic blood pressure; LUSC cis rs75804782 0.521 rs72982596 chr2:239454919 G/C cg18131467 chr2:239335373 ASB1 -0.63 -5.87 -0.31 1.03e-8 Morning vs. evening chronotype;Chronotype; LUSC cis rs7954584 0.635 rs11043242 chr12:122356293 G/C cg21171335 chr12:122356390 WDR66 0.61 9.05 0.44 1.22e-17 Mean corpuscular volume; LUSC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.06e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg26304593 chr6:42947056 PEX6 -0.52 -8.19 -0.41 5.67e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7843479 1.000 rs7821592 chr8:21811530 C/G cg17168535 chr8:21777572 XPO7 0.64 9.87 0.48 2.46e-20 Mean corpuscular volume; LUSC cis rs17125944 0.615 rs6572867 chr14:53319283 C/T cg00686598 chr14:53173677 PSMC6 -0.61 -5.67 -0.3 3.04e-8 Alzheimer's disease (late onset); LUSC trans rs1941687 0.797 rs8096533 chr18:31383889 A/C cg27147174 chr7:100797783 AP1S1 -0.46 -6.81 -0.35 4.54e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs11249608 0.548 rs10516150 chr5:178459169 G/C cg21905437 chr5:178450457 ZNF879 0.43 5.7 0.3 2.65e-8 Pubertal anthropometrics; LUSC cis rs4887067 1 rs4887067 chr15:78886947 G/A cg06917634 chr15:78832804 PSMA4 -0.43 -5.94 -0.31 7.33e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs1577917 0.958 rs11754330 chr6:86455070 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.07 -0.36 9.36e-12 Response to antipsychotic treatment; LUSC cis rs30380 0.632 rs26496 chr5:96137882 A/G cg16492584 chr5:96139282 ERAP1 -0.57 -7.71 -0.39 1.46e-13 Cerebrospinal fluid biomarker levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26807643 chr1:11741683 MAD2L2 -0.43 -6.27 -0.32 1.1e-9 Electrocardiographic conduction measures; LUSC cis rs6496667 0.509 rs2253419 chr15:90945875 A/G cg22089800 chr15:90895588 ZNF774 0.54 7.81 0.39 7.5e-14 Rheumatoid arthritis; LUSC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs7605827 0.930 rs2287635 chr2:15704410 C/G cg19274914 chr2:15703543 NA 0.46 8.64 0.43 2.43e-16 Educational attainment (years of education); LUSC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg09835421 chr16:68378352 PRMT7 -0.55 -6.16 -0.32 2.09e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg06108461 chr20:60628389 TAF4 -0.75 -12.16 -0.55 1.97e-28 Body mass index; LUSC cis rs907612 0.638 rs907611 chr11:1874072 G/A cg26158194 chr11:1874320 LSP1 0.37 6.76 0.35 6.02e-11 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs11603020 0.950 rs78624400 chr11:57375463 G/C cg23127183 chr11:57508653 C11orf31 -0.46 -6.28 -0.32 1.06e-9 Blood protein levels; LUSC cis rs6120849 0.707 rs6120826 chr20:33671831 G/A cg24642439 chr20:33292090 TP53INP2 0.58 6.52 0.34 2.65e-10 Protein C levels; LUSC cis rs9796 0.870 rs11855248 chr15:41276158 G/A cg18705301 chr15:41695430 NDUFAF1 -0.42 -7.24 -0.37 3.12e-12 Menopause (age at onset); LUSC cis rs9361491 0.508 rs9352613 chr6:79424433 C/T cg05283184 chr6:79620031 NA 0.38 6.92 0.35 2.3e-11 Intelligence (multi-trait analysis); LUSC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg20243544 chr17:37824526 PNMT 0.52 7.44 0.38 8.47e-13 Asthma; LUSC cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.41e-23 Bladder cancer; LUSC cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs662064 0.962 rs607941 chr1:10539543 C/T cg20482658 chr1:10539492 PEX14 -0.33 -6.69 -0.34 9.27e-11 Asthma; LUSC cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg08999081 chr20:33150536 PIGU 0.37 6.76 0.35 6.31e-11 Height; LUSC cis rs11039100 0.681 rs11039120 chr11:5833096 A/G cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg12016809 chr21:47604291 C21orf56 -0.46 -6.97 -0.36 1.68e-11 Testicular germ cell tumor; LUSC cis rs679087 0.932 rs721617 chr12:29934586 C/T cg14258853 chr12:29935411 TMTC1 0.96 16.53 0.67 2.88e-45 Schizophrenia; LUSC cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg24690094 chr11:67383802 NA -0.45 -8.33 -0.41 2.14e-15 Mean corpuscular volume; LUSC cis rs12618769 0.625 rs76362434 chr2:99118005 C/T cg10123293 chr2:99228465 UNC50 0.5 7.92 0.4 3.67e-14 Bipolar disorder; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg16606324 chr3:10149918 C3orf24 0.67 9.71 0.47 8.57e-20 Alzheimer's disease; LUSC cis rs25422 0.938 rs62422193 chr6:118912285 G/A cg18833306 chr6:118973337 C6orf204 -0.46 -5.83 -0.3 1.34e-8 Renal cell carcinoma; LUSC cis rs6750795 0.746 rs1667301 chr2:232423717 C/T cg19187155 chr2:232395269 NMUR1 0.93 18.3 0.71 2.66e-52 Height; LUSC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg26314531 chr2:26401878 FAM59B 0.72 10.1 0.48 4.02e-21 Gut microbiome composition (summer); LUSC cis rs6961069 0.585 rs10265215 chr7:80257204 G/C cg04458919 chr7:80252533 CD36 -0.41 -7.28 -0.37 2.49e-12 Platelet count; LUSC cis rs9905704 0.918 rs36071323 chr17:56916804 C/T cg12560992 chr17:57184187 TRIM37 0.57 8.05 0.4 1.47e-14 Testicular germ cell tumor; LUSC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg15839431 chr19:19639596 YJEFN3 -0.7 -7.58 -0.38 3.43e-13 Bipolar disorder; LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.73 0.6 2.42e-34 Alzheimer's disease; LUSC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC cis rs3936840 0.548 rs1190545 chr14:102904179 G/C cg18135206 chr14:102964638 TECPR2 -0.46 -6.09 -0.32 3.06e-9 Plateletcrit; LUSC trans rs57046232 0.552 rs6054147 chr20:6336002 A/G cg21095983 chr6:86352623 SYNCRIP -0.47 -7.01 -0.36 1.33e-11 Colorectal cancer; LUSC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg00334542 chr7:100209784 MOSPD3 -0.48 -5.69 -0.3 2.82e-8 Other erythrocyte phenotypes; LUSC cis rs7659604 0.540 rs11098643 chr4:122701507 C/A cg06713675 chr4:122721982 EXOSC9 0.37 6.07 0.32 3.39e-9 Type 2 diabetes; LUSC cis rs11971779 0.680 rs7795520 chr7:139079207 A/G cg07862535 chr7:139043722 LUC7L2 0.55 6.89 0.35 2.8e-11 Diisocyanate-induced asthma; LUSC cis rs16866061 1.000 rs72974238 chr2:225432470 C/A cg12698349 chr2:225449008 CUL3 0.87 14.3 0.62 1.57e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs965513 1.000 rs10983700 chr9:100537455 T/C cg13688889 chr9:100608707 NA -0.57 -8.62 -0.43 2.68e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC trans rs11098499 0.954 rs9685777 chr4:120365965 C/A cg25214090 chr10:38739885 LOC399744 0.56 8.18 0.41 5.96e-15 Corneal astigmatism; LUSC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg23281280 chr6:28129359 ZNF389 0.42 5.65 0.3 3.39e-8 Parkinson's disease; LUSC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.83 -0.39 6.71e-14 Height; LUSC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg15556689 chr8:8085844 FLJ10661 -0.55 -8.33 -0.41 2.16e-15 Joint mobility (Beighton score); LUSC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.07 -0.44 1.02e-17 Gut microbiome composition (summer); LUSC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg02773041 chr1:40204384 PPIE 0.52 7.91 0.4 3.78e-14 Blood protein levels; LUSC cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14442939 chr10:27389572 ANKRD26 -0.9 -10.38 -0.49 4.59e-22 Breast cancer; LUSC cis rs925255 0.776 rs2279990 chr2:28636740 C/T cg01273330 chr2:28605224 NA -0.44 -7.29 -0.37 2.29e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg13256891 chr4:100009986 ADH5 0.46 6.24 0.32 1.35e-9 Alcohol dependence; LUSC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg26597838 chr10:835615 NA 0.96 13.34 0.59 7.57e-33 Eosinophil percentage of granulocytes; LUSC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg09650180 chr20:62225654 GMEB2 -0.67 -9.54 -0.46 3e-19 Glioblastoma; LUSC cis rs7107174 1.000 rs2373009 chr11:77945815 T/A cg02023728 chr11:77925099 USP35 0.48 6.47 0.33 3.54e-10 Testicular germ cell tumor; LUSC cis rs422421 1.000 rs396007 chr5:176518426 T/C cg00618323 chr5:176515533 FGFR4 0.37 5.98 0.31 5.89e-9 Height; LUSC cis rs7098414 0.511 rs10887826 chr10:82151380 C/T cg00277334 chr10:82204260 NA -0.55 -8.94 -0.44 2.71e-17 Post bronchodilator FEV1; LUSC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg17173187 chr15:85201210 NMB 0.37 6.51 0.34 2.83e-10 Schizophrenia; LUSC cis rs3087591 0.708 rs2854311 chr17:29671327 C/T cg24425628 chr17:29625626 OMG;NF1 0.48 7.18 0.37 4.52e-12 Hip circumference; LUSC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 8.84 0.44 5.48e-17 Schizophrenia; LUSC trans rs9944715 0.954 rs13381525 chr18:43747538 G/A cg01718231 chr17:29326311 RNF135 0.51 7.19 0.37 4.3e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg03676636 chr4:99064102 C4orf37 0.32 7.05 0.36 1.06e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs68170813 0.652 rs7784906 chr7:107148386 C/T cg24556660 chr7:106842632 COG5;HBP1 -0.46 -5.69 -0.3 2.79e-8 Coronary artery disease; LUSC cis rs6464929 0.956 rs66691097 chr7:148705943 C/G cg23583168 chr7:148888333 NA 0.47 5.99 0.31 5.41e-9 Pediatric bone mineral content (hip); LUSC cis rs1387259 0.929 rs2634666 chr12:48663670 G/T cg04545296 chr12:48745243 ZNF641 0.33 6.14 0.32 2.4e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs6460942 0.818 rs7780083 chr7:12233647 C/T cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs9611565 0.608 rs2003816 chr22:42095140 T/G cg17376030 chr22:41985996 PMM1 -0.44 -5.91 -0.31 8.5e-9 Vitiligo; LUSC cis rs11030122 0.702 rs66503725 chr11:3980998 G/A cg08557956 chr11:4115526 RRM1 -0.45 -5.69 -0.3 2.81e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs3806843 0.966 rs2563255 chr5:140142547 T/C cg26395211 chr5:140044315 WDR55 0.37 5.66 0.3 3.21e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2742417 0.603 rs2531755 chr3:45772742 T/C cg10512202 chr3:45649293 LIMD1 0.36 5.94 0.31 7.3e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg08280861 chr8:58055591 NA 0.57 6.03 0.31 4.4e-9 Developmental language disorder (linguistic errors); LUSC cis rs7617773 0.817 rs9819094 chr3:48319558 C/T cg11946769 chr3:48343235 NME6 0.84 14.12 0.61 8.06e-36 Coronary artery disease; LUSC cis rs7575217 0.767 rs796056 chr2:101735276 A/C cg23907051 chr2:101730305 TBC1D8 -0.28 -7.59 -0.38 3.24e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg11764359 chr7:65958608 NA -0.7 -10.79 -0.51 1.7e-23 Aortic root size; LUSC cis rs6121246 0.529 rs6060195 chr20:30185638 C/T cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs2637266 0.599 rs2395425 chr10:78461920 C/T cg18941641 chr10:78392320 NA 0.33 5.86 0.31 1.09e-8 Pulmonary function; LUSC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.63 -0.34 1.33e-10 Alzheimer's disease (late onset); LUSC cis rs854765 0.583 rs62064158 chr17:17826935 T/C cg04398451 chr17:18023971 MYO15A -0.48 -7.65 -0.39 2.12e-13 Total body bone mineral density; LUSC cis rs7786808 0.552 rs896762 chr7:158182029 A/G cg09998033 chr7:158218633 PTPRN2 0.49 7.89 0.4 4.3e-14 Obesity-related traits; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg19318889 chr4:1322082 MAEA 0.48 7.69 0.39 1.68e-13 Obesity-related traits; LUSC trans rs7824557 0.606 rs1435277 chr8:11196970 C/T cg15556689 chr8:8085844 FLJ10661 0.55 8.08 0.4 1.18e-14 Retinal vascular caliber; LUSC cis rs2227564 0.649 rs2688626 chr10:75611090 G/A cg23231163 chr10:75533350 FUT11 -0.42 -5.74 -0.3 2.08e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs947211 0.898 rs10900524 chr1:205748309 G/A cg24503407 chr1:205819492 PM20D1 0.43 5.65 0.3 3.5e-8 Parkinson's disease; LUSC cis rs240764 0.746 rs240153 chr6:101067135 A/C cg09795085 chr6:101329169 ASCC3 0.4 5.82 0.3 1.36e-8 Neuroticism; LUSC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg05738196 chr6:26577821 NA 0.48 7.17 0.37 4.79e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg00745463 chr17:30367425 LRRC37B -0.83 -9.75 -0.47 6.44e-20 Hip circumference adjusted for BMI; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg13997278 chr17:40118587 CNP 0.41 6.35 0.33 7.21e-10 Triglycerides; LUSC cis rs9300255 0.544 rs2049114 chr12:123657338 T/C cg05973401 chr12:123451056 ABCB9 0.53 6.52 0.34 2.64e-10 Neutrophil percentage of white cells; LUSC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg18876405 chr7:65276391 NA 0.59 9.59 0.46 2.09e-19 Aortic root size; LUSC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg24531977 chr5:56204891 C5orf35 -0.76 -10.76 -0.51 2.17e-23 Type 2 diabetes; LUSC cis rs72772090 0.539 rs11747148 chr5:96112863 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -7.27 -0.37 2.59e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg26597838 chr10:835615 NA 1.23 16.23 0.66 4.34e-44 Eosinophil percentage of granulocytes; LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC cis rs2073300 0.609 rs34648279 chr20:23402935 T/G cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22496380 chr5:211416 CCDC127 -0.81 -8.54 -0.42 4.82e-16 Breast cancer; LUSC cis rs6701037 0.875 rs6929 chr1:175126721 A/G cg00321850 chr1:175162397 KIAA0040 -0.4 -6.89 -0.35 2.81e-11 Alcohol dependence; LUSC trans rs11098499 0.909 rs28581362 chr4:120283548 T/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg09365446 chr1:150670422 GOLPH3L 0.47 7.02 0.36 1.24e-11 Melanoma; LUSC cis rs722599 0.748 rs3742783 chr14:75377008 C/T cg08847533 chr14:75593920 NEK9 -0.49 -7.08 -0.36 8.7e-12 IgG glycosylation; LUSC cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg18105134 chr13:113819100 PROZ -0.65 -9.8 -0.47 4.21e-20 Platelet distribution width; LUSC trans rs11610422 0.953 rs12824490 chr12:31414490 C/T cg02734259 chr12:9559402 NA -0.61 -6.48 -0.33 3.38e-10 Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13635462 chr11:77790613 NDUFC2 0.73 5.95 0.31 6.92e-9 Cognitive performance; LUSC cis rs1322512 0.917 rs2758818 chr6:152980753 G/C cg27316956 chr6:152958899 SYNE1 0.37 6.25 0.32 1.25e-9 Tonometry; LUSC trans rs1325195 0.920 rs12130276 chr1:179082525 C/T cg11624085 chr17:8464688 MYH10 -0.44 -7.29 -0.37 2.2e-12 IgE grass sensitization; LUSC cis rs887829 0.570 rs6753569 chr2:234595817 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -6.12 -0.32 2.56e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg25643088 chr3:52874325 TMEM110 0.39 5.82 0.3 1.4e-8 Schizophrenia; LUSC cis rs6598955 0.543 rs6698557 chr1:26561220 G/C cg04990556 chr1:26633338 UBXN11 0.88 11.8 0.54 4.15e-27 Obesity-related traits; LUSC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg06453172 chr10:134556979 INPP5A -0.5 -6.0 -0.31 5.21e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs17039065 1.000 rs72889372 chr4:109387298 A/G cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.24e-10 Gut microbiome composition (summer); LUSC cis rs12618769 0.597 rs2278208 chr2:99154229 C/T cg10123293 chr2:99228465 UNC50 0.5 8.12 0.41 9.4e-15 Bipolar disorder; LUSC cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.59 -0.38 3.21e-13 Personality dimensions; LUSC cis rs6882046 0.513 rs35148765 chr5:88046158 C/A cg22951263 chr5:87985283 NA -0.47 -7.72 -0.39 1.39e-13 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.61 -8.13 -0.41 8.71e-15 Systemic lupus erythematosus; LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg11766577 chr21:47581405 C21orf56 -0.56 -8.78 -0.43 8.84e-17 Testicular germ cell tumor; LUSC trans rs35110281 0.811 rs4819264 chr21:45017349 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.75 0.54 6.59e-27 Mean corpuscular volume; LUSC cis rs6429082 0.783 rs291365 chr1:235688043 A/G cg26050004 chr1:235667680 B3GALNT2 0.66 9.44 0.46 6.8e-19 Adiposity; LUSC cis rs1215050 0.765 rs181521 chr4:98745728 A/C cg05340658 chr4:99064831 C4orf37 0.44 6.92 0.35 2.25e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2361718 0.967 rs12942941 chr17:78103013 C/T cg09238746 chr17:78121135 EIF4A3 -0.63 -9.53 -0.46 3.47e-19 Yeast infection; LUSC cis rs4555082 0.874 rs78923231 chr14:105754033 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.3 -0.37 2.17e-12 Mean platelet volume;Platelet distribution width; LUSC trans rs12902680 0.641 rs7162533 chr15:46586095 T/C cg04321580 chr8:143696133 ARC -0.4 -6.04 -0.31 4.18e-9 Neuroticism; LUSC cis rs477692 1.000 rs508303 chr10:131424996 A/T cg11019008 chr10:131425282 MGMT -0.4 -6.07 -0.31 3.57e-9 Response to temozolomide; LUSC cis rs7089973 0.872 rs7074729 chr10:116632257 C/G cg23260525 chr10:116636907 FAM160B1 0.39 7.98 0.4 2.37e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9768139 0.524 rs7779175 chr7:158136918 C/T cg06219351 chr7:158114137 PTPRN2 0.47 7.41 0.38 1.02e-12 Calcium levels; LUSC cis rs950776 0.518 rs12906951 chr15:78825562 C/T cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs763121 0.925 rs1043312 chr22:39131727 T/G cg06544989 chr22:39130855 UNC84B 0.35 6.35 0.33 6.84e-10 Menopause (age at onset); LUSC trans rs637571 0.522 rs542332 chr11:65744421 C/T cg17712092 chr4:129076599 LARP1B 0.73 11.13 0.52 1.14e-24 Eosinophil percentage of white cells; LUSC cis rs17270561 0.609 rs1165208 chr6:25803904 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 6.51 0.34 2.78e-10 Iron status biomarkers; LUSC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg14552801 chr7:65878734 NA -0.43 -6.06 -0.31 3.77e-9 Aortic root size; LUSC cis rs7973719 0.773 rs6486911 chr12:7356494 G/C cg07052231 chr12:7363540 PEX5 0.54 9.42 0.46 7.85e-19 IgG glycosylation; LUSC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg15744005 chr10:104629667 AS3MT -0.29 -6.26 -0.32 1.15e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9807989 0.811 rs67088699 chr2:102968751 C/T cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.63e-9 Asthma; LUSC cis rs239198 0.555 rs9386258 chr6:101286336 C/G cg09795085 chr6:101329169 ASCC3 0.44 5.94 0.31 7.13e-9 Menarche (age at onset); LUSC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg06618935 chr21:46677482 NA -0.37 -7.26 -0.37 2.7e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1981331 1.000 rs79694455 chr21:47983979 C/T cg17243659 chr21:48055224 PRMT2 0.84 6.04 0.31 4.14e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg14829155 chr15:31115871 NA -0.72 -10.71 -0.51 3.4e-23 Huntington's disease progression; LUSC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg08847533 chr14:75593920 NEK9 -0.81 -13.69 -0.6 3.48e-34 Height; LUSC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg08470875 chr2:26401718 FAM59B 0.66 8.54 0.42 4.71e-16 Gut microbiome composition (summer); LUSC cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg08999081 chr20:33150536 PIGU 0.52 10.36 0.49 5.48e-22 Glomerular filtration rate (creatinine); LUSC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg24110177 chr3:50126178 RBM5 0.64 11.16 0.52 8.8e-25 Body mass index; LUSC cis rs6961069 0.774 rs1413661 chr7:80243003 G/C cg04458919 chr7:80252533 CD36 -0.36 -6.63 -0.34 1.32e-10 Platelet count; LUSC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs28541881 0.536 rs60061147 chr19:34804420 G/C cg00351152 chr3:12837017 CAND2 -0.67 -6.16 -0.32 2.08e-9 Colorectal cancer; LUSC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg16339924 chr4:17578868 LAP3 0.55 8.33 0.41 2.08e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6120849 0.754 rs6088682 chr20:33615702 A/C cg24642439 chr20:33292090 TP53INP2 0.61 6.74 0.35 6.84e-11 Protein C levels; LUSC cis rs7267979 0.816 rs6138593 chr20:25504492 A/G cg03522245 chr20:25566470 NINL 0.35 5.74 0.3 2.15e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9291683 0.588 rs35438220 chr4:9999398 C/T cg00071950 chr4:10020882 SLC2A9 0.66 11.18 0.52 7.3e-25 Bone mineral density; LUSC cis rs2084898 0.506 rs531260 chr11:120050515 C/T cg07435449 chr11:120005650 TRIM29 0.37 6.62 0.34 1.41e-10 Stroke (pediatric); LUSC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg16339924 chr4:17578868 LAP3 0.58 8.99 0.44 1.91e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg06481639 chr22:41940642 POLR3H 0.49 5.82 0.3 1.38e-8 Vitiligo; LUSC cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.63 0.34 1.39e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg23625390 chr15:77176239 SCAPER 0.51 7.91 0.4 3.79e-14 Blood metabolite levels; LUSC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg05234568 chr11:5960015 NA -0.57 -8.22 -0.41 4.69e-15 DNA methylation (variation); LUSC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.06 -0.36 9.71e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7568458 0.516 rs62166769 chr2:85812784 T/A cg23752985 chr2:85803571 VAMP8 0.3 5.97 0.31 5.97e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg11871910 chr12:69753446 YEATS4 0.92 17.37 0.69 1.28e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs8062405 0.720 rs9926245 chr16:28555706 T/A cg16576597 chr16:28551801 NUPR1 0.29 5.85 0.3 1.18e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1775715 0.835 rs12266771 chr10:32231380 G/A cg03015672 chr10:32216066 ARHGAP12 0.32 5.79 0.3 1.63e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.38 0.53 1.43e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg17554472 chr22:41940697 POLR3H -0.46 -5.8 -0.3 1.53e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.49 5.84 0.3 1.23e-8 Renal function-related traits (BUN); LUSC cis rs11122272 0.701 rs2474628 chr1:231526000 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs2414856 0.510 rs77109323 chr15:64704941 G/A cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Pulse pressure;Systolic blood pressure; LUSC cis rs17292804 0.506 rs71417868 chr14:104046592 A/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -6.54 -0.34 2.36e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.22 -0.37 3.56e-12 Bipolar disorder; LUSC trans rs9329221 0.521 rs4841294 chr8:10105068 G/T cg06636001 chr8:8085503 FLJ10661 -0.42 -6.08 -0.32 3.36e-9 Neuroticism; LUSC cis rs11155671 0.530 rs9383914 chr6:150207234 T/G cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.15e-11 Testicular germ cell tumor; LUSC cis rs6845621 0.727 rs10026502 chr4:18910167 T/C cg12196642 chr4:18937545 NA -0.33 -6.22 -0.32 1.45e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs1577917 0.958 rs1591437 chr6:86525305 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.78 -0.43 8.6e-17 Response to antipsychotic treatment; LUSC cis rs1577917 1.000 rs34106666 chr6:86676258 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.79e-10 Response to antipsychotic treatment; LUSC trans rs853679 1.000 rs1936365 chr6:28268452 C/G cg01620082 chr3:125678407 NA 0.51 6.44 0.33 4.28e-10 Depression; LUSC cis rs72772090 0.539 rs72775818 chr5:96193215 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.88 -0.35 2.88e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6964587 1.000 rs12539231 chr7:91634963 G/A cg22709100 chr7:91322751 NA 0.41 6.07 0.32 3.44e-9 Breast cancer; LUSC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg18512352 chr11:47633146 NA -0.47 -9.41 -0.46 8.03e-19 Subjective well-being; LUSC cis rs1506636 0.889 rs619075 chr7:123426317 A/T cg03229431 chr7:123269106 ASB15 0.65 10.64 0.5 6.03e-23 Plateletcrit;Platelet count; LUSC cis rs7651511 0.611 rs1582875 chr3:141192125 A/T cg00789793 chr3:141329863 RASA2 0.38 5.82 0.3 1.41e-8 Mean corpuscular hemoglobin; LUSC cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.82 -0.47 3.69e-20 Chronic sinus infection; LUSC cis rs61931739 0.517 rs11611190 chr12:34015697 G/A cg06521331 chr12:34319734 NA -0.47 -7.57 -0.38 3.58e-13 Morning vs. evening chronotype; LUSC cis rs6545883 0.860 rs13023037 chr2:61620989 C/T cg15711740 chr2:61764176 XPO1 0.44 6.89 0.35 2.82e-11 Tuberculosis; LUSC cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg25427524 chr10:38739819 LOC399744 -0.72 -13.31 -0.59 1.04e-32 Extrinsic epigenetic age acceleration; LUSC cis rs11677370 0.561 rs13015012 chr2:3821252 C/G cg17052675 chr2:3827356 NA 0.63 10.16 0.49 2.59e-21 Type 2 diabetes; LUSC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.4 5.72 0.3 2.33e-8 Menopause (age at onset); LUSC cis rs2573652 1.000 rs2581363 chr15:100513364 G/A cg09918751 chr15:100517450 ADAMTS17 -0.4 -7.2 -0.37 4.07e-12 Height; LUSC cis rs11785693 0.862 rs17350978 chr8:4983418 G/C cg26367366 chr8:4980734 NA 0.81 9.58 0.46 2.36e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs4908769 0.624 rs301790 chr1:8469284 G/C cg00546117 chr1:8445545 RERE -0.28 -5.65 -0.3 3.37e-8 Allergy; LUSC cis rs908922 0.628 rs488393 chr1:152489548 C/T cg20991723 chr1:152506922 NA 0.5 9.54 0.46 3.1e-19 Hair morphology; LUSC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg18350739 chr11:68623251 NA -0.34 -5.95 -0.31 6.79e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg05347473 chr6:146136440 FBXO30 0.49 8.32 0.41 2.22e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs921968 0.565 rs13408305 chr2:219628183 G/A cg02176678 chr2:219576539 TTLL4 -0.58 -10.35 -0.49 5.81e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg22681709 chr2:178499509 PDE11A -0.57 -11.32 -0.53 2.22e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs853679 0.505 rs200992 chr6:27814677 A/G cg01620082 chr3:125678407 NA -0.74 -7.22 -0.37 3.44e-12 Depression; LUSC cis rs9322193 0.567 rs7742692 chr6:150213499 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Lung cancer; LUSC cis rs524023 0.914 rs2277311 chr11:64387932 G/A cg19131476 chr11:64387923 NRXN2 -0.38 -10.37 -0.49 4.87e-22 Urate levels in obese individuals; LUSC cis rs7572733 0.534 rs700673 chr2:198692929 A/G cg00792783 chr2:198669748 PLCL1 0.43 5.7 0.3 2.66e-8 Dermatomyositis; LUSC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg07636037 chr3:49044803 WDR6 0.88 13.48 0.59 2.35e-33 Menarche (age at onset); LUSC cis rs11098499 0.691 rs9996494 chr4:120238880 C/A cg24375607 chr4:120327624 NA 0.75 11.83 0.54 3.24e-27 Corneal astigmatism; LUSC cis rs6460942 0.915 rs2192842 chr7:12315752 C/G cg06484146 chr7:12443880 VWDE -0.49 -5.84 -0.3 1.27e-8 Coronary artery disease; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg11596580 chr12:3600764 PRMT8 0.49 6.17 0.32 1.97e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg03433033 chr1:76189801 ACADM 0.82 12.93 0.58 2.84e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.45 -0.46 6.09e-19 Electroencephalogram traits; LUSC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg02079420 chr8:82753780 SNX16 -0.38 -5.7 -0.3 2.64e-8 Diastolic blood pressure; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.81 -0.39 7.37e-14 Lymphocyte counts; LUSC cis rs3096299 0.967 rs753853 chr16:89446525 G/T cg08392591 chr16:89556376 ANKRD11 0.39 5.75 0.3 1.97e-8 Multiple myeloma (IgH translocation); LUSC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.09 -0.36 8.25e-12 Alzheimer's disease (late onset); LUSC cis rs6089584 0.546 rs4925337 chr20:60637637 T/C cg06108461 chr20:60628389 TAF4 -0.76 -12.44 -0.56 1.85e-29 Body mass index; LUSC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg06740227 chr12:86229804 RASSF9 0.39 6.15 0.32 2.22e-9 Major depressive disorder; LUSC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.27 -0.32 1.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1178968 0.901 rs1178953 chr7:72781277 A/G cg25889504 chr7:72793014 NA 0.61 7.94 0.4 3.08e-14 Triglyceride levels; LUSC cis rs1023500 0.573 rs2413666 chr22:42459622 C/T cg15557168 chr22:42548783 NA -0.41 -6.22 -0.32 1.52e-9 Schizophrenia; LUSC trans rs12458462 0.892 rs3786228 chr18:77464170 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 0.45 6.53 0.34 2.42e-10 Monocyte count; LUSC cis rs4478858 0.806 rs6686845 chr1:31708796 A/T cg00250761 chr1:31883323 NA -0.38 -9.94 -0.48 1.44e-20 Alcohol dependence; LUSC trans rs6600671 1.000 rs10903161 chr1:121178741 A/T cg08727972 chr1:148025634 NBPF14 0.45 6.28 0.32 1.08e-9 Hip geometry; LUSC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.66 9.28 0.45 2.13e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg02527881 chr3:46936655 PTH1R -0.44 -7.93 -0.4 3.24e-14 Colorectal cancer; LUSC trans rs9291683 0.552 rs10939655 chr4:10014642 A/T cg26043149 chr18:55253948 FECH 0.49 7.28 0.37 2.43e-12 Bone mineral density; LUSC cis rs11792861 0.591 rs2282206 chr9:111746267 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.65 10.95 0.51 4.95e-24 Menarche (age at onset); LUSC cis rs1018836 0.798 rs28568272 chr8:91652958 A/G cg16814680 chr8:91681699 NA -0.93 -17.73 -0.7 4.75e-50 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6693567 0.565 rs832621 chr1:150392909 G/C cg15654264 chr1:150340011 RPRD2 0.43 6.81 0.35 4.55e-11 Migraine; LUSC cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg01483505 chr11:975446 AP2A2 -0.43 -6.24 -0.32 1.29e-9 Alzheimer's disease (late onset); LUSC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg05585544 chr11:47624801 NA -0.41 -7.23 -0.37 3.22e-12 Subjective well-being; LUSC trans rs2950393 0.804 rs7967600 chr12:57161992 A/G cg14367344 chr1:146644336 PRKAB2 -0.42 -5.98 -0.31 5.65e-9 Platelet distribution width; LUSC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg21280719 chr6:42927975 GNMT -0.31 -7.66 -0.39 1.97e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg18350739 chr11:68623251 NA 0.36 6.57 0.34 1.95e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg03188948 chr7:1209495 NA 0.45 6.02 0.31 4.64e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs874628 0.576 rs72999466 chr19:18248499 C/T cg00493341 chr19:18228948 MAST3 0.44 6.16 0.32 2.14e-9 Multiple sclerosis; LUSC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg21724239 chr8:58056113 NA 0.81 8.84 0.44 5.66e-17 Developmental language disorder (linguistic errors); LUSC cis rs3925075 1.000 rs4411512 chr16:31347445 C/T cg02846316 chr16:31340340 ITGAM 0.36 6.66 0.34 1.11e-10 IgA nephropathy; LUSC cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg11584989 chr19:19387371 SF4 0.58 7.02 0.36 1.22e-11 Bipolar disorder; LUSC cis rs35146811 0.700 rs7788301 chr7:99782753 C/G cg13334819 chr7:99746414 C7orf59 -0.5 -6.73 -0.35 7.41e-11 Coronary artery disease; LUSC cis rs2742417 0.603 rs2673032 chr3:45756927 C/T cg10512202 chr3:45649293 LIMD1 0.36 6.06 0.31 3.65e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg00074818 chr8:8560427 CLDN23 0.58 9.91 0.48 1.88e-20 Obesity-related traits; LUSC cis rs4629180 0.586 rs1509494 chr2:102134862 G/T cg01388757 chr2:102091195 RFX8 -0.37 -6.47 -0.33 3.39e-10 Chronic rhinosinusitis with nasal polyps; LUSC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg06505273 chr16:24850292 NA -0.4 -5.7 -0.3 2.58e-8 Intelligence (multi-trait analysis); LUSC cis rs10769945 0.679 rs7105710 chr11:1918083 T/C cg06197492 chr11:2016605 H19 0.41 6.98 0.36 1.55e-11 DNA methylation (variation); LUSC trans rs61931739 0.529 rs1525900 chr12:33976652 T/G cg26384229 chr12:38710491 ALG10B 0.5 7.68 0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.18 -0.41 6.16e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg04450456 chr4:17643702 FAM184B 0.35 5.81 0.3 1.47e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.42 0.53 9.8e-26 Prudent dietary pattern; LUSC cis rs8113142 0.651 rs56293350 chr19:29109841 C/T cg04546413 chr19:29218101 NA 0.43 5.88 0.31 1.02e-8 Femoral neck bone geometry and menarche (age at onset); LUSC trans rs9747201 0.862 rs57596657 chr17:80147978 C/T cg07393940 chr7:158741817 NA 0.54 8.75 0.43 1.06e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11051970 0.918 rs1055876 chr12:32536200 C/T cg02745156 chr12:32552066 NA 0.43 6.89 0.35 2.84e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg15921436 chr17:44337874 NA 0.64 9.63 0.47 1.52e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg08219700 chr8:58056026 NA 0.54 6.56 0.34 2.05e-10 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.932 rs446649 chr20:25467359 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.9 20.92 0.75 1.07e-62 Liver enzyme levels (alkaline phosphatase); LUSC trans rs62103177 0.810 rs62096745 chr18:77619135 A/G cg05926928 chr17:57297772 GDPD1 1.45 17.66 0.69 9.33e-50 Opioid sensitivity; LUSC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg07716408 chr11:68623521 NA -0.3 -5.85 -0.3 1.2e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg23590916 chr17:43697445 MGC57346 0.5 6.64 0.34 1.26e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9527 1.000 rs9527 chr10:104623578 C/T cg15744005 chr10:104629667 AS3MT -0.35 -6.57 -0.34 1.99e-10 Arsenic metabolism; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg07507251 chr3:52567010 NT5DC2 0.36 7.32 0.37 1.89e-12 Electroencephalogram traits; LUSC cis rs59918340 0.764 rs4961258 chr8:142232878 A/G cg23750338 chr8:142222470 SLC45A4 -0.59 -11.47 -0.53 6.9e-26 Immature fraction of reticulocytes; LUSC cis rs12541635 0.966 rs11786829 chr8:107023752 C/G cg10147462 chr8:107024639 NA 0.56 10.17 0.49 2.33e-21 Age of smoking initiation; LUSC cis rs644799 0.601 rs568878 chr11:95578694 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.71 11.45 0.53 7.83e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg21724239 chr8:58056113 NA 0.55 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1801251 1.000 rs67013068 chr2:233608253 G/C cg25237894 chr2:233734115 C2orf82 0.35 6.5 0.34 2.92e-10 Coronary artery disease; LUSC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg00271210 chr6:167070053 RPS6KA2 0.28 5.7 0.3 2.62e-8 Crohn's disease; LUSC cis rs6121246 0.523 rs6060286 chr20:30197663 C/A cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs1018836 0.923 rs2105967 chr8:91587522 A/G cg16814680 chr8:91681699 NA -0.75 -12.44 -0.56 1.93e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.56 0.38 3.84e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7927592 0.913 rs2236708 chr11:68378045 G/A cg16797656 chr11:68205561 LRP5 0.37 6.09 0.32 3.02e-9 Total body bone mineral density; LUSC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg26116260 chr4:7069785 GRPEL1 1.09 17.16 0.68 9.45e-48 Monocyte percentage of white cells; LUSC cis rs2742234 0.541 rs1317214 chr10:43733531 C/G cg02780029 chr10:43622663 RET 0.34 5.68 0.3 2.97e-8 Hirschsprung disease; LUSC cis rs546131 0.928 rs547504 chr11:34847225 G/T cg06937548 chr11:34938143 PDHX;APIP 0.47 6.74 0.35 7.02e-11 Lung disease severity in cystic fibrosis; LUSC cis rs16854884 0.606 rs60676654 chr3:143734937 A/G cg06585982 chr3:143692056 C3orf58 0.5 8.13 0.41 8.55e-15 Economic and political preferences (feminism/equality); LUSC cis rs10791323 0.511 rs4937837 chr11:133731134 T/C cg00579200 chr11:133705235 NA -0.39 -5.86 -0.31 1.14e-8 Childhood ear infection; LUSC cis rs8078723 1.000 rs3213762 chr17:38178627 A/G cg17467752 chr17:38218738 THRA 0.78 12.48 0.56 1.34e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2898290 0.540 rs12677146 chr8:11450737 C/G cg21775007 chr8:11205619 TDH -0.4 -5.7 -0.3 2.61e-8 Systolic blood pressure; LUSC cis rs506338 0.517 rs17146216 chr11:64451281 C/G cg19395706 chr11:64412079 NRXN2 0.29 5.82 0.3 1.38e-8 Body mass index;Urate levels; LUSC cis rs6084875 0.840 rs1999665 chr20:4720988 C/T cg07258627 chr20:4721683 PRNT -0.34 -6.2 -0.32 1.69e-9 Systemic lupus erythematosus; LUSC cis rs2404602 0.669 rs8036703 chr15:76951040 A/G cg22467129 chr15:76604101 ETFA -0.43 -6.81 -0.35 4.53e-11 Blood metabolite levels; LUSC cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg06671660 chr6:41068741 NFYA;LOC221442 -0.46 -6.36 -0.33 6.73e-10 Alzheimer's disease (late onset); LUSC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg14668632 chr7:2872130 GNA12 0.41 6.27 0.32 1.13e-9 Height; LUSC cis rs6456156 0.586 rs911632 chr6:167471461 T/C cg06454157 chr6:167490870 NA -0.27 -6.64 -0.34 1.28e-10 Primary biliary cholangitis; LUSC cis rs10740039 0.516 rs10740034 chr10:62352382 C/T cg18175470 chr10:62150864 ANK3 -0.45 -6.78 -0.35 5.55e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1595825 0.945 rs73056880 chr2:198822292 G/A cg00982548 chr2:198649783 BOLL -0.58 -7.29 -0.37 2.32e-12 Ulcerative colitis; LUSC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.99 0.4 2.22e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg12935359 chr14:103987150 CKB -0.53 -8.12 -0.41 9.2e-15 Body mass index; LUSC cis rs6693567 0.565 rs834242 chr1:150379858 G/A cg15654264 chr1:150340011 RPRD2 0.43 6.88 0.35 2.96e-11 Migraine; LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs80130819 0.636 rs2732470 chr12:48664757 T/G cg24011408 chr12:48396354 COL2A1 0.46 5.84 0.3 1.22e-8 Prostate cancer; LUSC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg21285383 chr16:89894308 SPIRE2 0.33 6.98 0.36 1.63e-11 Vitiligo; LUSC cis rs3003334 1 rs3003334 chr1:24199869 G/A cg10978503 chr1:24200527 CNR2 0.54 13.24 0.59 1.85e-32 Eosinophil percentage of white cells;Eosinophil percentage of granulocytes; LUSC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg04414720 chr1:150670196 GOLPH3L -0.41 -6.26 -0.32 1.2e-9 Tonsillectomy; LUSC cis rs1609391 0.543 rs9859810 chr3:136629986 A/G cg15507776 chr3:136538369 TMEM22 0.51 8.36 0.42 1.71e-15 Neuroticism; LUSC cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.95 -14.28 -0.62 1.95e-36 Chronic sinus infection; LUSC cis rs5769707 0.521 rs9616715 chr22:50058582 C/T cg05373962 chr22:49881684 NA -0.4 -8.46 -0.42 8.69e-16 Monocyte count;Monocyte percentage of white cells; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg04260516 chr14:24630327 IRF9 0.51 6.44 0.33 4.09e-10 Cognitive function;Information processing speed; LUSC cis rs4690686 0.500 rs7683662 chr4:177272004 A/T cg17059388 chr4:177262070 NA 0.49 9.05 0.44 1.17e-17 Essential tremor; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.58 -9.37 -0.46 1.14e-18 Lymphocyte counts; LUSC cis rs3812762 0.879 rs10743089 chr11:8788168 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -7.07 -0.36 9.12e-12 Hypospadias; LUSC cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.87 0.66 1.21e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.22 0.49 1.68e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.909 rs10017335 chr4:120381523 C/G cg25214090 chr10:38739885 LOC399744 -0.54 -8.03 -0.4 1.64e-14 Corneal astigmatism; LUSC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg12257692 chr3:49977190 RBM6 -0.25 -6.8 -0.35 4.84e-11 Intelligence (multi-trait analysis); LUSC cis rs9646944 0.501 rs17027246 chr2:103080055 C/G cg20060108 chr2:102954350 IL1RL1 0.45 6.08 0.32 3.22e-9 Blood protein levels; LUSC cis rs61931739 0.534 rs1843733 chr12:34047626 T/C cg06521331 chr12:34319734 NA -0.49 -8.13 -0.41 8.54e-15 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg05313129 chr8:58192883 C8orf71 -0.51 -6.61 -0.34 1.52e-10 Developmental language disorder (linguistic errors); LUSC cis rs7100689 0.622 rs1340383 chr10:82095968 T/G cg00277334 chr10:82204260 NA -0.57 -8.67 -0.43 1.9e-16 Post bronchodilator FEV1; LUSC cis rs453301 0.522 rs2929309 chr8:9083771 C/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.39 -0.38 1.15e-12 Joint mobility (Beighton score); LUSC cis rs35883536 0.588 rs12568329 chr1:101104588 A/G cg06223162 chr1:101003688 GPR88 -0.36 -6.38 -0.33 6.07e-10 Monocyte count; LUSC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg11301795 chr4:187892539 NA -0.81 -16.05 -0.66 2.25e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9644630 0.841 rs3185 chr8:19328959 A/C cg01280390 chr8:19363452 CSGALNACT1 -0.32 -5.81 -0.3 1.42e-8 Oropharynx cancer; LUSC cis rs644799 0.544 rs498553 chr11:95534441 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.61 9.18 0.45 4.77e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs11764590 0.694 rs55860148 chr7:2105594 G/A cg02825527 chr7:2087843 MAD1L1 -0.48 -5.78 -0.3 1.75e-8 Neuroticism; LUSC cis rs7772486 0.727 rs10223508 chr6:146285205 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.26 0.37 2.7e-12 Lobe attachment (rater-scored or self-reported); LUSC trans rs1325195 0.920 rs2816211 chr1:179192238 C/T cg11624085 chr17:8464688 MYH10 0.41 6.69 0.34 9.35e-11 IgE grass sensitization; LUSC cis rs8038465 0.638 rs62004615 chr15:73957799 C/A cg15420318 chr15:73925796 NPTN 0.59 9.89 0.48 2.22e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs17685 0.725 rs6467993 chr7:75719350 G/A cg19862616 chr7:65841803 NCRNA00174 1.11 19.03 0.72 3.14e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg18132916 chr6:79620363 NA -0.38 -5.77 -0.3 1.85e-8 Intelligence (multi-trait analysis); LUSC trans rs890100 0.739 rs987575 chr2:56752041 C/G cg01657744 chr10:88471748 LDB3 0.45 6.11 0.32 2.75e-9 Gut microbiome composition (summer); LUSC trans rs7786808 0.741 rs11767875 chr7:158228923 A/G cg02030672 chr11:45687055 CHST1 0.45 6.74 0.35 6.79e-11 Obesity-related traits; LUSC cis rs9814567 1.000 rs9989967 chr3:134238964 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.28 -0.59 1.35e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg02073558 chr3:44770973 ZNF501 0.57 9.41 0.46 8.29e-19 Depressive symptoms; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs9291683 0.526 rs12506122 chr4:10033538 C/A cg26043149 chr18:55253948 FECH 0.49 7.42 0.38 9.52e-13 Bone mineral density; LUSC cis rs10740039 0.516 rs958852 chr10:62322618 T/A cg18175470 chr10:62150864 ANK3 -0.45 -6.89 -0.35 2.87e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs367943 0.730 rs2914174 chr5:112978531 C/T cg12552261 chr5:112820674 MCC -0.4 -6.13 -0.32 2.51e-9 Type 2 diabetes; LUSC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.08 -0.32 3.31e-9 Developmental language disorder (linguistic errors); LUSC cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg08601574 chr20:25228251 PYGB 0.44 6.75 0.35 6.5e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg01973587 chr1:228161476 NA 0.45 8.02 0.4 1.8e-14 Diastolic blood pressure; LUSC trans rs853679 0.517 rs9357066 chr6:28129831 T/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg08499158 chr17:42289980 UBTF 0.38 6.03 0.31 4.39e-9 Red cell distribution width;Reticulocyte count; LUSC trans rs6030 0.872 rs6686805 chr1:169512643 A/C cg16792071 chr10:134842795 NA 0.28 5.97 0.31 6.18e-9 Uric acid levels; LUSC cis rs4604732 0.631 rs12031721 chr1:247623773 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.31 0.33 9.08e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg14004847 chr7:1930337 MAD1L1 -0.5 -7.52 -0.38 4.96e-13 Bipolar disorder and schizophrenia; LUSC cis rs8072100 0.905 rs9895274 chr17:45539117 C/T cg25173405 chr17:45401733 C17orf57 -0.41 -6.44 -0.33 4.2e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4423214 0.819 rs7938885 chr11:71170043 T/C cg05163923 chr11:71159392 DHCR7 0.74 11.0 0.52 3.15e-24 Vitamin D levels; LUSC cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg14343924 chr8:8086146 FLJ10661 0.42 5.93 0.31 7.42e-9 Mood instability; LUSC trans rs2980439 0.525 rs2980508 chr8:8171732 C/T cg21775007 chr8:11205619 TDH 0.45 6.26 0.32 1.17e-9 Neuroticism; LUSC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg15839431 chr19:19639596 YJEFN3 -0.41 -5.7 -0.3 2.61e-8 Tonsillectomy; LUSC cis rs9420 0.961 rs499188 chr11:57434122 C/A cg23127183 chr11:57508653 C11orf31 -0.52 -7.83 -0.39 6.7e-14 Schizophrenia; LUSC cis rs10876993 1.000 rs10876993 chr12:58062667 C/T cg15848620 chr12:58087721 OS9 -0.55 -7.85 -0.39 5.64e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.866 rs12374352 chr4:120281977 C/T cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs4443100 0.837 rs6003490 chr22:23388447 G/A cg21100191 chr22:23484243 RTDR1 0.54 6.45 0.33 3.88e-10 Serum parathyroid hormone levels; LUSC trans rs6507022 0.934 rs6507038 chr18:31030946 A/G cg19867917 chr2:3642629 COLEC11 0.3 6.02 0.31 4.7e-9 Metabolite levels (X-11787); LUSC cis rs12478296 0.591 rs4973646 chr2:243001373 C/T cg06360820 chr2:242988706 NA 0.61 7.68 0.39 1.78e-13 Obesity-related traits; LUSC cis rs6460942 0.556 rs2287067 chr7:12370533 T/C cg20607287 chr7:12443886 VWDE -0.47 -5.75 -0.3 1.99e-8 Coronary artery disease; LUSC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg20891283 chr12:69753455 YEATS4 0.67 11.29 0.53 2.84e-25 Blood protein levels; LUSC cis rs765787 0.530 rs7165889 chr15:45531640 T/C cg25801113 chr15:45476975 SHF 0.35 7.17 0.37 4.84e-12 Uric acid levels; LUSC cis rs7954584 0.583 rs6486782 chr12:122359172 T/C cg21016266 chr12:122356598 WDR66 0.54 7.69 0.39 1.62e-13 Mean corpuscular volume; LUSC cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg02527881 chr3:46936655 PTH1R -0.38 -6.71 -0.34 8.33e-11 Colorectal cancer; LUSC cis rs6733011 0.508 rs6542843 chr2:99533729 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.04 -0.36 1.1e-11 Bipolar disorder; LUSC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg04369109 chr6:150039330 LATS1 -0.58 -8.78 -0.43 8.37e-17 Lung cancer; LUSC cis rs9399135 0.967 rs2327580 chr6:135364417 A/C cg24558204 chr6:135376177 HBS1L 0.58 9.03 0.44 1.39e-17 Red blood cell count; LUSC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg00944433 chr1:107599041 PRMT6 0.38 7.07 0.36 9.36e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg11062466 chr8:58055876 NA 0.71 8.53 0.42 5.07e-16 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08843538 chr2:210288784 MAP2 0.46 7.94 0.4 3.2e-14 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg05347473 chr6:146136440 FBXO30 -0.47 -7.87 -0.4 5.09e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg24060327 chr5:131705240 SLC22A5 -0.67 -11.36 -0.53 1.61e-25 Breast cancer; LUSC cis rs7605827 0.930 rs11893272 chr2:15613796 C/T cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs9914988 0.943 rs34693224 chr17:27079555 C/T cg19789473 chr17:27170043 C17orf63 -0.31 -5.74 -0.3 2.13e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs9693857 0.520 rs4841163 chr8:9366178 C/G cg08975724 chr8:8085496 FLJ10661 0.42 5.98 0.31 5.68e-9 Systolic blood pressure; LUSC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.84 -0.35 3.88e-11 Monocyte percentage of white cells; LUSC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg21285383 chr16:89894308 SPIRE2 0.31 6.58 0.34 1.79e-10 Vitiligo; LUSC cis rs6138458 0.961 rs227625 chr20:24911618 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.1 0.7 1.58e-51 Blood protein levels; LUSC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg23093090 chr10:104574429 C10orf26 -0.41 -7.36 -0.37 1.42e-12 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs4921915 0.526 rs13277738 chr8:18241507 C/T cg18736775 chr8:18248649 NAT2 -0.58 -6.55 -0.34 2.18e-10 Iron status biomarkers (transferrin levels); LUSC cis rs9399135 0.935 rs11759999 chr6:135370495 G/T cg24558204 chr6:135376177 HBS1L 0.58 9.03 0.44 1.38e-17 Red blood cell count; LUSC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg22823121 chr1:150693482 HORMAD1 0.48 7.06 0.36 9.78e-12 Melanoma; LUSC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg05890377 chr2:74357713 NA 0.71 11.6 0.54 2.34e-26 Gestational age at birth (maternal effect); LUSC cis rs1451375 0.572 rs745042 chr7:50544138 A/G cg18232548 chr7:50535776 DDC -0.54 -7.45 -0.38 8.23e-13 Malaria; LUSC trans rs11098499 0.863 rs3775843 chr4:120427844 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.7e-10 Corneal astigmatism; LUSC cis rs12438659 1 rs12438659 chr15:78824924 G/A cg24631222 chr15:78858424 CHRNA5 0.83 11.27 0.52 3.54e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg13072238 chr3:49761600 GMPPB -0.36 -5.84 -0.3 1.27e-8 Intelligence (multi-trait analysis); LUSC cis rs1662342 1.000 rs1791107 chr18:3251861 T/C cg00760847 chr18:3262519 MYL12B -0.58 -5.68 -0.3 2.97e-8 QRS duration; LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.6 0.54 2.33e-26 Prudent dietary pattern; LUSC cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg20701182 chr2:24300061 SF3B14 0.88 11.42 0.53 1.05e-25 Lymphocyte counts; LUSC trans rs61931739 0.500 rs10844864 chr12:34532468 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.05 0.44 1.2e-17 Morning vs. evening chronotype; LUSC trans rs28647808 0.881 rs28602295 chr9:136267471 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs12908161 1.000 rs12908549 chr15:85322351 C/G cg17507749 chr15:85114479 UBE2QP1 0.53 6.58 0.34 1.87e-10 Schizophrenia; LUSC cis rs8179 0.645 rs11764331 chr7:92282624 C/T cg15732164 chr7:92237376 CDK6 -0.4 -5.71 -0.3 2.46e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg08132940 chr7:1081526 C7orf50 -0.52 -6.15 -0.32 2.27e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs72634258 0.838 rs10489450 chr1:8079301 C/T cg00042356 chr1:8021962 PARK7 0.77 9.68 0.47 1.1e-19 Inflammatory bowel disease; LUSC cis rs1790761 0.692 rs674783 chr11:67339076 C/T cg00290607 chr11:67383545 NA 0.37 6.88 0.35 3.04e-11 Mean corpuscular volume; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg14893161 chr1:205819251 PM20D1 -0.92 -18.14 -0.7 1.17e-51 Menarche (age at onset); LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg22638593 chr5:131593259 PDLIM4 0.49 7.47 0.38 7e-13 Acylcarnitine levels; LUSC cis rs3924048 0.559 rs4075304 chr1:12626803 C/T cg00291366 chr1:12616550 NA 0.32 7.23 0.37 3.42e-12 Optic cup area; LUSC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg05347473 chr6:146136440 FBXO30 0.57 9.78 0.47 5.04e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7808935 0.914 rs11982766 chr7:27983781 C/T cg22168087 chr7:27702803 HIBADH 0.54 6.49 0.33 3.09e-10 Prostate cancer; LUSC cis rs62400317 0.826 rs17288327 chr6:45349877 A/G cg18551225 chr6:44695536 NA -0.42 -7.02 -0.36 1.28e-11 Total body bone mineral density; LUSC cis rs6840360 0.571 rs62327269 chr4:152527973 G/C cg22705602 chr4:152727874 NA -0.33 -6.58 -0.34 1.84e-10 Intelligence (multi-trait analysis); LUSC cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.67 -0.34 1.08e-10 Monocyte percentage of white cells; LUSC cis rs34375054 0.525 rs12316499 chr12:125593318 G/A cg06287003 chr12:125626642 AACS -0.39 -6.84 -0.35 3.89e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg24846343 chr22:24311635 DDTL 0.76 17.05 0.68 2.37e-47 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg24250549 chr1:154909240 PMVK 0.64 10.42 0.5 3.35e-22 Prostate cancer; LUSC cis rs10992471 0.580 rs7030920 chr9:95122952 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -7.94 -0.4 3.15e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4654899 0.785 rs10916911 chr1:21290061 C/T cg01072550 chr1:21505969 NA -0.53 -8.08 -0.4 1.23e-14 Superior frontal gyrus grey matter volume; LUSC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg15448220 chr1:150897856 SETDB1 0.38 5.66 0.3 3.19e-8 Tonsillectomy; LUSC trans rs11039798 0.925 rs12277669 chr11:48925316 A/T cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18404041 chr3:52824283 ITIH1 -0.54 -10.44 -0.5 2.85e-22 Electroencephalogram traits; LUSC cis rs1395 0.744 rs4665962 chr2:27515105 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 6.16 0.32 2.1e-9 Blood metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21370986 chr7:6145114 USP42 -0.4 -6.31 -0.33 9.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs926938 0.527 rs360684 chr1:115499001 A/G cg01522456 chr1:115632236 TSPAN2 -0.41 -6.31 -0.33 8.63e-10 Autism; LUSC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg27121462 chr16:89883253 FANCA -0.42 -6.49 -0.33 3.14e-10 Vitiligo; LUSC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.52 0.38 5.03e-13 Bipolar disorder; LUSC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg13770153 chr20:60521292 NA 0.73 9.97 0.48 1.11e-20 Body mass index; LUSC cis rs8017423 0.967 rs11159956 chr14:90715890 C/T cg04374321 chr14:90722782 PSMC1 -0.75 -11.88 -0.55 2.15e-27 Mortality in heart failure; LUSC cis rs1448094 0.967 rs6539934 chr12:86343973 G/A cg18827107 chr12:86230957 RASSF9 -0.39 -5.83 -0.3 1.3e-8 Major depressive disorder; LUSC cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg01657329 chr11:68192670 LRP5 -0.44 -6.55 -0.34 2.19e-10 Total body bone mineral density; LUSC cis rs7208859 0.623 rs73269913 chr17:29092183 T/C cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9303401 0.659 rs12150264 chr17:56939927 G/A cg25039879 chr17:56429692 SUPT4H1 0.68 9.11 0.45 7.7e-18 Cognitive test performance; LUSC cis rs2658782 0.789 rs56091149 chr11:93073640 A/C cg15737290 chr11:93063684 CCDC67 -0.67 -7.97 -0.4 2.55e-14 Pulmonary function decline; LUSC trans rs10221833 1.000 rs355829 chr2:165616315 G/T cg17870553 chr6:144292355 PLAGL1 0.64 6.61 0.34 1.55e-10 Response to statin therapy; LUSC cis rs644148 0.803 rs2686771 chr19:44999494 T/C cg15540054 chr19:45004280 ZNF180 -0.63 -9.36 -0.46 1.18e-18 Personality dimensions; LUSC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.68 -0.34 1.02e-10 Lung cancer; LUSC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.98 0.31 5.68e-9 Menopause (age at onset); LUSC cis rs4363385 0.693 rs56347903 chr1:152932175 T/G cg00922841 chr1:152955080 SPRR1A -0.41 -6.68 -0.34 1.03e-10 Inflammatory skin disease; LUSC cis rs6541297 1.000 rs1997947 chr1:230283764 A/G cg20703242 chr1:230279135 GALNT2 -0.55 -8.76 -0.43 1.02e-16 Coronary artery disease; LUSC cis rs738322 0.805 rs2235344 chr22:38518083 G/A cg25457927 chr22:38595422 NA -0.39 -7.74 -0.39 1.23e-13 Cutaneous nevi; LUSC cis rs3087591 0.960 rs12943508 chr17:29599954 C/G cg24425628 chr17:29625626 OMG;NF1 0.57 8.29 0.41 2.75e-15 Hip circumference; LUSC cis rs738321 0.757 rs4820315 chr22:38518731 C/T cg25457927 chr22:38595422 NA -0.38 -7.09 -0.36 8.09e-12 Breast cancer; LUSC trans rs11098499 0.955 rs1397608 chr4:120161744 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.27 0.32 1.09e-9 Corneal astigmatism; LUSC cis rs57920188 0.640 rs4378174 chr1:4080885 C/T cg20703997 chr1:4087676 NA 0.58 8.17 0.41 6.6e-15 Interleukin-17 levels; LUSC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg12751644 chr20:60527061 NA -0.35 -6.22 -0.32 1.52e-9 Body mass index; LUSC cis rs8114671 0.662 rs6058146 chr20:33540529 A/G cg24642439 chr20:33292090 TP53INP2 0.43 6.26 0.32 1.2e-9 Height; LUSC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg02503808 chr4:7069936 GRPEL1 1.01 14.64 0.63 8.04e-38 Monocyte percentage of white cells; LUSC cis rs11785400 0.793 rs35985277 chr8:143736137 C/T cg24634471 chr8:143751801 JRK 0.51 7.34 0.37 1.59e-12 Schizophrenia; LUSC cis rs4803468 0.967 rs3745290 chr19:41890003 C/T cg09537434 chr19:41945824 ATP5SL -0.89 -15.71 -0.65 5.14e-42 Height; LUSC cis rs983392 0.679 rs4938932 chr11:60033448 C/T cg20284999 chr11:59952153 MS4A6A 0.37 6.15 0.32 2.19e-9 Alzheimer's disease (late onset); LUSC cis rs8077889 0.917 rs6503479 chr17:41917003 A/G cg26893861 chr17:41843967 DUSP3 0.88 13.56 0.6 1.16e-33 Triglycerides; LUSC cis rs7582180 0.629 rs4851297 chr2:100949571 G/A cg12002119 chr2:101014098 CHST10 0.35 5.65 0.3 3.48e-8 Intelligence (multi-trait analysis); LUSC trans rs11039798 1.000 rs34044596 chr11:48527936 T/C cg15704280 chr7:45808275 SEPT13 0.7 6.63 0.34 1.36e-10 Axial length; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26970905 chr8:8175877 PRAGMIN -0.81 -6.42 -0.33 4.8e-10 Cognitive performance; LUSC cis rs6987853 0.527 rs3935700 chr8:42364121 T/C cg09913449 chr8:42400586 C8orf40 -0.44 -7.68 -0.39 1.82e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs11098499 0.708 rs1546506 chr4:120241240 T/C cg09307838 chr4:120376055 NA 0.69 10.16 0.49 2.54e-21 Corneal astigmatism; LUSC trans rs1325195 0.920 rs2793793 chr1:179140145 C/G cg11624085 chr17:8464688 MYH10 0.4 6.53 0.34 2.44e-10 IgE grass sensitization; LUSC cis rs9811920 0.742 rs2316263 chr3:99900096 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.32 6.21 0.32 1.61e-9 Axial length; LUSC cis rs1559088 0.600 rs10421769 chr19:33605312 T/C cg03563238 chr19:33554763 RHPN2 -0.38 -6.56 -0.34 2.09e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17412528 chr7:76178955 LOC100133091 -0.41 -6.11 -0.32 2.77e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15104702 chr7:106685023 PRKAR2B -0.4 -5.98 -0.31 5.78e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.62 0.43 2.64e-16 Menarche (age at onset); LUSC cis rs950169 0.881 rs62029599 chr15:84956565 A/C cg17173187 chr15:85201210 NMB 0.37 6.4 0.33 5.31e-10 Schizophrenia; LUSC cis rs17094222 0.504 rs4917904 chr10:102447292 G/A cg26540559 chr10:102447443 NA 0.52 8.9 0.44 3.72e-17 Body mass index;BMI (adjusted for smoking behaviour);Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13041975 chr2:99952790 EIF5B;TXNDC9 -0.41 -6.04 -0.31 4.12e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4664308 0.691 rs1877196 chr2:160915150 G/T cg03641300 chr2:160917029 PLA2R1 -0.63 -10.62 -0.5 6.75e-23 Idiopathic membranous nephropathy; LUSC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg05090351 chr10:126851162 NA -0.52 -8.32 -0.41 2.3e-15 Menarche (age at onset); LUSC trans rs890100 0.902 rs1155883 chr2:56738467 G/A cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.32 -6.17 -0.32 1.95e-9 Gut microbiome composition (summer); LUSC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg05855489 chr10:104503620 C10orf26 -0.69 -10.2 -0.49 1.86e-21 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs11098499 0.820 rs13128602 chr4:120459366 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.49 -6.71 -0.34 8.55e-11 Corneal astigmatism; LUSC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.03e-36 Eye color traits; LUSC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 14.39 0.62 7.35e-37 Platelet count; LUSC cis rs9905704 0.633 rs2021733 chr17:56489168 C/T cg12560992 chr17:57184187 TRIM37 -0.49 -5.8 -0.3 1.51e-8 Testicular germ cell tumor; LUSC cis rs2692947 0.732 rs56847058 chr2:96406893 C/T cg22654517 chr2:96458247 NA 0.35 6.65 0.34 1.21e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18404041 chr3:52824283 ITIH1 -0.44 -8.07 -0.4 1.28e-14 Electroencephalogram traits; LUSC cis rs34779708 0.966 rs12769575 chr10:35435927 A/T cg04310649 chr10:35416472 CREM -0.43 -6.64 -0.34 1.27e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg25427524 chr10:38739819 LOC399744 -0.59 -10.55 -0.5 1.24e-22 Extrinsic epigenetic age acceleration; LUSC cis rs6665290 0.669 rs3768419 chr1:227173477 C/G cg10327440 chr1:227177885 CDC42BPA -1.11 -29.0 -0.85 3.1e-93 Myeloid white cell count; LUSC cis rs72781680 0.898 rs113522526 chr2:24018476 C/T cg08917208 chr2:24149416 ATAD2B 0.86 9.48 0.46 5e-19 Lymphocyte counts; LUSC cis rs11112613 0.713 rs12307351 chr12:105955634 T/A cg03607813 chr12:105948248 NA 0.81 11.34 0.53 1.99e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs61931739 0.929 rs2389272 chr12:34067771 T/C cg26384229 chr12:38710491 ALG10B -0.59 -9.6 -0.47 1.91e-19 Morning vs. evening chronotype; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg09060608 chr5:178986726 RUFY1 0.75 14.67 0.63 6.07e-38 Lung cancer; LUSC cis rs2236918 0.643 rs3121389 chr1:242020264 C/T cg17736920 chr1:242011382 EXO1 0.4 6.22 0.32 1.5e-9 Menopause (age at onset); LUSC cis rs2797160 1.000 rs9401843 chr6:126004124 T/C cg05901451 chr6:126070800 HEY2 -0.57 -8.56 -0.42 4.29e-16 Endometrial cancer; LUSC trans rs11098499 0.863 rs3775847 chr4:120447642 A/C cg25214090 chr10:38739885 LOC399744 0.53 7.59 0.38 3.3e-13 Corneal astigmatism; LUSC cis rs4561483 0.743 rs28653099 chr16:12009150 C/A cg08843971 chr16:11963173 GSPT1 0.43 6.58 0.34 1.83e-10 Testicular germ cell tumor; LUSC cis rs3617 0.539 rs9985365 chr3:52953844 A/G cg18404041 chr3:52824283 ITIH1 0.47 8.43 0.42 1.08e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg20476274 chr7:133979776 SLC35B4 0.86 16.11 0.66 1.27e-43 Mean platelet volume; LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg02187348 chr16:89574699 SPG7 0.57 9.15 0.45 5.89e-18 Multiple myeloma (IgH translocation); LUSC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg03233332 chr7:66118400 NA -0.42 -6.1 -0.32 2.88e-9 Aortic root size; LUSC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg18131467 chr2:239335373 ASB1 1.05 25.09 0.81 7.84e-79 Multiple system atrophy; LUSC cis rs10089 0.953 rs10045113 chr5:127386631 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.81 11.51 0.53 4.93e-26 Ileal carcinoids; LUSC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.8 0.35 4.74e-11 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg18230493 chr5:56204884 C5orf35 -0.86 -13.06 -0.58 8.73e-32 Initial pursuit acceleration; LUSC cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg05347473 chr6:146136440 FBXO30 -0.56 -9.71 -0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs4343996 0.506 rs7790430 chr7:3432943 G/C cg21248987 chr7:3385318 SDK1 0.37 6.1 0.32 2.87e-9 Motion sickness; LUSC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg00129232 chr17:37814104 STARD3 -0.49 -7.29 -0.37 2.24e-12 Asthma; LUSC cis rs7903847 0.642 rs10882911 chr10:99138064 A/C cg20016023 chr10:99160130 RRP12 -0.34 -8.25 -0.41 3.65e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs6750047 0.546 rs985257 chr2:38283228 A/T cg07380506 chr2:38303506 CYP1B1 -0.5 -6.85 -0.35 3.5e-11 Cutaneous malignant melanoma;Melanoma; LUSC cis rs8060686 0.641 rs9938553 chr16:68183064 T/A cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs317689 0.819 rs317683 chr12:69713630 T/G cg11871910 chr12:69753446 YEATS4 0.47 6.33 0.33 7.74e-10 Response to diuretic therapy; LUSC trans rs61931739 0.500 rs11053210 chr12:34461771 A/G cg13010199 chr12:38710504 ALG10B -0.62 -9.46 -0.46 5.77e-19 Morning vs. evening chronotype; LUSC cis rs9303401 0.659 rs36109237 chr17:56653834 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC cis rs858239 0.601 rs6971002 chr7:23172304 C/G cg23682824 chr7:23144976 KLHL7 0.39 5.67 0.3 3.16e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.38 -6.03 -0.31 4.26e-9 Alzheimer's disease (late onset); LUSC cis rs11662586 1.000 rs7243921 chr18:77695237 G/A cg20368463 chr18:77673604 PQLC1 0.62 8.36 0.42 1.69e-15 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.27 -0.32 1.09e-9 Lung cancer; LUSC cis rs7809950 0.954 rs62482543 chr7:107080656 G/A cg23024343 chr7:107201750 COG5 -0.55 -8.73 -0.43 1.21e-16 Coronary artery disease; LUSC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg22467129 chr15:76604101 ETFA -0.42 -6.64 -0.34 1.28e-10 Blood metabolite levels; LUSC cis rs12908161 0.959 rs34028043 chr15:85231585 G/A cg17507749 chr15:85114479 UBE2QP1 0.56 6.96 0.36 1.8e-11 Schizophrenia; LUSC cis rs73206853 0.841 rs73191818 chr12:110918721 T/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg18306943 chr3:40428807 ENTPD3 0.4 5.98 0.31 5.73e-9 Renal cell carcinoma; LUSC cis rs7208859 0.573 rs8070182 chr17:29135594 A/C cg13385521 chr17:29058706 SUZ12P 0.65 6.53 0.34 2.48e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs62400317 0.762 rs62436411 chr6:44940706 T/G cg18551225 chr6:44695536 NA -0.44 -7.16 -0.36 5.08e-12 Total body bone mineral density; LUSC trans rs12210905 0.925 rs12192502 chr6:26995720 A/C cg01357846 chr2:79252794 REG3G -0.34 -6.08 -0.32 3.27e-9 Hip circumference adjusted for BMI; LUSC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg07414643 chr4:187882934 NA 0.57 11.13 0.52 1.12e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Body mass index; LUSC trans rs1908814 0.516 rs11250178 chr8:11800234 A/C cg15556689 chr8:8085844 FLJ10661 0.58 8.82 0.43 6.5e-17 Neuroticism; LUSC cis rs1843834 0.858 rs4674933 chr2:225514923 C/T cg22455342 chr2:225449267 CUL3 0.46 6.14 0.32 2.32e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs4969178 0.895 rs2292640 chr17:76396610 G/A cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs4555082 0.874 rs4677 chr14:105717279 T/C cg13114125 chr14:105738426 BRF1 -0.91 -16.03 -0.66 2.8e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.52 -7.11 -0.36 7.25e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2486288 0.656 rs8024620 chr15:45574329 C/T cg09092052 chr15:45571596 NA 0.46 6.37 0.33 6.18e-10 Glomerular filtration rate; LUSC cis rs71391092 1 rs71391092 chr16:74567075 C/G cg01733217 chr16:74700730 RFWD3 -0.72 -7.61 -0.38 2.9e-13 Schizophrenia; LUSC cis rs2607426 1.000 rs2607421 chr19:41277077 A/G cg05508168 chr19:41255947 C19orf54;SNRPA 0.63 5.72 0.3 2.32e-8 Blood protein levels; LUSC cis rs853679 0.607 rs66868086 chr6:27865902 A/T cg26958806 chr6:27640298 NA 0.76 5.72 0.3 2.39e-8 Depression; LUSC cis rs8013055 0.796 rs8005568 chr14:105971794 A/G cg19700328 chr14:106028568 NA -0.42 -7.08 -0.36 8.65e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs3126085 0.877 rs4456098 chr1:152176034 C/T cg03465714 chr1:152285911 FLG -0.41 -5.66 -0.3 3.21e-8 Atopic dermatitis; LUSC cis rs929354 0.742 rs6459734 chr7:156935454 A/G cg17757837 chr7:157058334 UBE3C 0.82 13.21 0.59 2.39e-32 Body mass index; LUSC cis rs7829975 0.684 rs488904 chr8:8587571 T/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.14 -0.36 5.96e-12 Mood instability; LUSC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg06637938 chr14:75390232 RPS6KL1 0.86 16.1 0.66 1.4e-43 Caffeine consumption; LUSC cis rs870825 0.616 rs28524599 chr4:185647414 A/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs9549367 0.789 rs9549716 chr13:113908478 G/A cg18105134 chr13:113819100 PROZ -0.65 -9.59 -0.46 2.1e-19 Platelet distribution width; LUSC cis rs9300255 0.512 rs2851436 chr12:123667354 G/T cg00376283 chr12:123451042 ABCB9 0.67 8.36 0.42 1.68e-15 Neutrophil percentage of white cells; LUSC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg06484146 chr7:12443880 VWDE -0.66 -7.17 -0.37 4.87e-12 Coronary artery disease; LUSC cis rs478304 0.627 rs11604568 chr11:65511336 G/A cg10518572 chr11:65560635 OVOL1 -0.25 -5.66 -0.3 3.25e-8 Acne (severe); LUSC cis rs6584202 0.589 rs10883094 chr10:100188106 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -6.82 -0.35 4.17e-11 Obesity-related traits; LUSC cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg12927641 chr6:109611667 NA -0.36 -6.15 -0.32 2.19e-9 Reticulocyte fraction of red cells; LUSC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.28 0.32 1.08e-9 Height; LUSC cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg01256987 chr12:42539512 GXYLT1 -0.45 -8.67 -0.43 1.89e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg13395646 chr4:1353034 KIAA1530 -0.59 -8.44 -0.42 9.78e-16 Longevity; LUSC cis rs1595825 0.891 rs73058876 chr2:198895022 A/G cg00982548 chr2:198649783 BOLL -0.54 -6.89 -0.35 2.72e-11 Ulcerative colitis; LUSC trans rs11098499 0.774 rs73842616 chr4:120290683 G/A cg25214090 chr10:38739885 LOC399744 0.49 7.53 0.38 4.82e-13 Corneal astigmatism; LUSC trans rs17266958 1.000 rs62576990 chr9:83298644 G/A cg01905489 chr1:26616534 UBXN11 -0.58 -6.38 -0.33 6.04e-10 Preschool internalizing problems; LUSC cis rs977987 0.843 rs8056080 chr16:75410798 C/A cg03315344 chr16:75512273 CHST6 0.53 10.37 0.49 4.96e-22 Dupuytren's disease; LUSC trans rs11098499 0.863 rs3736115 chr4:120488703 A/G cg25214090 chr10:38739885 LOC399744 -0.5 -7.35 -0.37 1.51e-12 Corneal astigmatism; LUSC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg11871910 chr12:69753446 YEATS4 -0.7 -11.87 -0.54 2.28e-27 Blood protein levels; LUSC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg02187348 chr16:89574699 SPG7 0.49 7.5 0.38 5.65e-13 Multiple myeloma (IgH translocation); LUSC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg11764359 chr7:65958608 NA 0.67 10.44 0.5 2.93e-22 Aortic root size; LUSC cis rs17621444 0.522 rs4373838 chr10:121809445 A/G cg02041677 chr10:121771263 NA -0.36 -6.82 -0.35 4.22e-11 IgG glycosylation; LUSC cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg06784218 chr1:46089804 CCDC17 0.54 11.06 0.52 1.88e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7208859 0.623 rs7217984 chr17:29092766 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.91 0.48 1.8899999999999998e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2730245 0.527 rs842693 chr7:158660491 C/T cg11984989 chr7:158649758 WDR60 1.13 13.89 0.6 6.42e-35 Height; LUSC cis rs5771069 0.933 rs137848 chr22:50440296 A/G cg03721641 chr22:50451245 IL17REL 0.28 5.97 0.31 6.11e-9 Ulcerative colitis; LUSC trans rs13259667 0.500 rs4554442 chr8:78092543 A/G cg04164058 chr15:89949694 NA -0.48 -6.48 -0.33 3.22e-10 Behavioural disinhibition (generation interaction); LUSC cis rs926938 0.521 rs360649 chr1:115439668 G/C cg01522456 chr1:115632236 TSPAN2 -0.39 -5.85 -0.31 1.15e-8 Autism; LUSC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg02018176 chr4:1364513 KIAA1530 0.5 8.83 0.44 5.87e-17 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07097636 chr17:26646373 TMEM97 -0.41 -5.98 -0.31 5.6e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg09184832 chr6:79620586 NA -0.44 -7.24 -0.37 3.16e-12 Intelligence (multi-trait analysis); LUSC cis rs2688608 0.868 rs2688625 chr10:75631548 T/C cg23231163 chr10:75533350 FUT11 -0.41 -6.43 -0.33 4.45e-10 Inflammatory bowel disease; LUSC cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg18681998 chr4:17616180 MED28 0.74 13.43 0.59 3.44e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs62380364 0.542 rs2247885 chr5:88047999 T/C cg22951263 chr5:87985283 NA -0.48 -7.89 -0.4 4.43e-14 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg23711669 chr6:146136114 FBXO30 0.75 13.38 0.59 5.42e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg10150615 chr22:24372951 LOC391322 0.38 6.42 0.33 4.63e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs853679 0.517 rs11552219 chr6:28126834 C/T cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.19e-9 Depression; LUSC cis rs17253792 0.822 rs74968702 chr14:56076818 A/T cg01858014 chr14:56050164 KTN1 -0.88 -7.15 -0.36 5.56e-12 Putamen volume; LUSC cis rs5770917 1.000 rs2269385 chr22:51010939 G/A cg01081346 chr22:51017151 CPT1B;CHKB-CPT1B -0.62 -5.73 -0.3 2.26e-8 Narcolepsy; LUSC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg20135002 chr11:47629003 NA -0.46 -7.54 -0.38 4.41e-13 Subjective well-being; LUSC cis rs912057 0.526 rs201061 chr6:6730512 C/T cg06612196 chr6:6737390 NA -0.61 -12.63 -0.57 3.64e-30 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03352830 chr11:487213 PTDSS2 0.74 8.83 0.43 6.22e-17 Body mass index; LUSC cis rs7264396 0.563 rs6060558 chr20:34271092 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -8.52 -0.42 5.65e-16 Total cholesterol levels; LUSC cis rs701145 0.585 rs62276839 chr3:153780407 C/T cg17054900 chr3:154042577 DHX36 -0.74 -7.56 -0.38 4.04e-13 Coronary artery disease; LUSC cis rs17253792 0.822 rs10136155 chr14:56049129 G/A cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs7289126 1.000 rs4820328 chr22:38635679 C/T cg25457927 chr22:38595422 NA -0.3 -6.0 -0.31 5.19e-9 Mammographic density (dense area);Percent mammographic density; LUSC cis rs6964587 1.000 rs58965837 chr7:91585258 T/A cg17063962 chr7:91808500 NA 0.58 9.26 0.45 2.59e-18 Breast cancer; LUSC cis rs7258465 1.000 rs10405636 chr19:18538742 A/C cg06462663 chr19:18546047 ISYNA1 0.44 7.27 0.37 2.6e-12 Breast cancer; LUSC cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg02269571 chr22:50332266 NA 0.73 9.41 0.46 8.12e-19 Schizophrenia; LUSC cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg23711669 chr6:146136114 FBXO30 0.92 17.68 0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg17509989 chr5:176798049 RGS14 0.69 11.24 0.52 4.33e-25 Hemoglobin concentration;Hematocrit; LUSC cis rs2041895 0.565 rs10861679 chr12:107322915 T/C cg13944111 chr12:107296891 NA 0.35 6.69 0.34 9.3e-11 Glaucoma (low intraocular pressure); LUSC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg04287289 chr16:89883240 FANCA 0.77 6.23 0.32 1.42e-9 Skin colour saturation; LUSC cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg11752832 chr7:134001865 SLC35B4 0.5 7.22 0.37 3.62e-12 Mean platelet volume; LUSC cis rs7705502 1.000 rs72812811 chr5:173350990 G/A cg18693985 chr5:173351052 CPEB4 -0.38 -5.97 -0.31 6.06e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs17095355 1.000 rs13377169 chr10:111729414 A/G cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.44 -0.38 8.8e-13 Biliary atresia; LUSC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg22029157 chr1:209979665 IRF6 0.51 8.27 0.41 3.33e-15 Monobrow; LUSC cis rs6681460 0.800 rs539014 chr1:67211887 C/T cg02459107 chr1:67143332 SGIP1 -0.47 -8.33 -0.41 2.14e-15 Presence of antiphospholipid antibodies; LUSC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg18681998 chr4:17616180 MED28 0.74 13.59 0.6 8.62e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg09085632 chr11:111637200 PPP2R1B 1.0 15.05 0.64 1.96e-39 Primary sclerosing cholangitis; LUSC cis rs11711311 1.000 rs10212375 chr3:113471336 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.9 0.35 2.64e-11 IgG glycosylation; LUSC cis rs8014204 0.935 rs2853779 chr14:75368508 G/A cg06637938 chr14:75390232 RPS6KL1 -0.67 -11.16 -0.52 8.79e-25 Caffeine consumption; LUSC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg04287289 chr16:89883240 FANCA 0.79 14.01 0.61 2.06e-35 Vitiligo; LUSC cis rs11583043 1.000 rs11583043 chr1:101466054 C/T cg11406453 chr1:101602562 NA -0.33 -5.68 -0.3 2.9e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs11098499 0.863 rs13136462 chr4:120543173 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.39 0.33 5.53e-10 Corneal astigmatism; LUSC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg11062466 chr8:58055876 NA 0.75 12.78 0.57 1.0500000000000001e-30 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.863 rs34308924 chr4:120481431 T/C cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs7923609 0.967 rs10740126 chr10:65210935 A/G cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.03e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.08 -0.4 1.2e-14 Mood instability; LUSC trans rs7726839 0.507 rs72703100 chr5:614291 C/T cg11887960 chr12:57824829 NA 0.53 6.54 0.34 2.35e-10 Obesity-related traits; LUSC cis rs1801251 1.000 rs778166 chr2:233664097 A/T cg08000102 chr2:233561755 GIGYF2 0.72 11.87 0.54 2.43e-27 Coronary artery disease; LUSC trans rs62056376 0.736 rs2215185 chr17:32633902 C/T cg19986872 chr5:131347773 ACSL6 -0.38 -5.98 -0.31 5.73e-9 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs3755132 0.929 rs7594193 chr2:15750640 C/T cg12888861 chr2:15731646 DDX1 -0.53 -7.71 -0.39 1.47e-13 Wilms tumor; LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.94 0.48 1.4e-20 Bipolar disorder; LUSC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.79 0.51 1.7e-23 Menopause (age at onset); LUSC cis rs3099143 1.000 rs4886832 chr15:77121196 G/A cg21673338 chr15:77095150 SCAPER 0.77 7.47 0.38 7.08e-13 Recalcitrant atopic dermatitis; LUSC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.59 -0.34 1.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg24675658 chr1:53192096 ZYG11B 0.64 10.07 0.48 5.11e-21 Monocyte count; LUSC cis rs67460515 0.892 rs7610985 chr3:161062848 G/A cg03342759 chr3:160939853 NMD3 -0.49 -6.85 -0.35 3.53e-11 Parkinson's disease; LUSC cis rs1448094 0.967 rs2405789 chr12:86320466 C/T cg00310523 chr12:86230176 RASSF9 -0.37 -6.71 -0.34 8.16e-11 Major depressive disorder; LUSC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11890956 chr21:40555474 PSMG1 1.0 17.96 0.7 5.97e-51 Cognitive function; LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.87 -0.58 4.63e-31 Platelet count; LUSC cis rs427941 0.703 rs1734879 chr7:101740610 C/A cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs597583 0.715 rs4938399 chr11:117398399 C/T cg27161313 chr11:117392002 DSCAML1 -0.51 -8.19 -0.41 5.58e-15 Putamen volume; LUSC cis rs8008758 0.517 rs1772024 chr14:101695220 A/C cg26224664 chr14:101693935 NA 0.39 10.18 0.49 2.29e-21 Body mass index (alcohol intake interaction); LUSC cis rs17401966 1.000 rs4845934 chr1:10468946 G/A cg19773385 chr1:10388646 KIF1B -0.53 -8.23 -0.41 4.39e-15 Hepatocellular carcinoma; LUSC cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg00071950 chr4:10020882 SLC2A9 0.64 10.64 0.5 5.62e-23 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1595825 0.786 rs77773624 chr2:198514845 G/A cg00982548 chr2:198649783 BOLL -0.52 -6.57 -0.34 1.95e-10 Ulcerative colitis; LUSC cis rs4356932 0.817 rs6826398 chr4:76973546 A/G cg00809888 chr4:76862425 NAAA 0.35 5.82 0.3 1.37e-8 Blood protein levels; LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.11 -0.48 3.97e-21 Obesity-related traits; LUSC cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.74 12.63 0.57 3.84e-30 Personality dimensions; LUSC cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg11584989 chr19:19387371 SF4 0.6 7.31 0.37 1.93e-12 Bipolar disorder; LUSC cis rs3806843 1.000 rs12055222 chr5:140165568 T/C cg19875535 chr5:140030758 IK 0.47 7.66 0.39 2.01e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs6142102 0.602 rs932388 chr20:32657378 C/T cg24642439 chr20:33292090 TP53INP2 0.4 5.71 0.3 2.49e-8 Skin pigmentation; LUSC cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg06784218 chr1:46089804 CCDC17 -0.48 -9.23 -0.45 3.17e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg23205692 chr1:25664452 TMEM50A 0.45 6.71 0.34 8.39e-11 Erythrocyte sedimentation rate; LUSC cis rs2458413 0.563 rs2458422 chr8:105332817 C/T cg04554929 chr8:105342491 NA -0.41 -7.37 -0.37 1.33e-12 Paget's disease; LUSC cis rs1775715 0.513 rs2808089 chr10:32145112 A/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.84 0.35 3.81e-11 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7819412 0.668 rs920047 chr8:11087475 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.69 -0.39 1.68e-13 Triglycerides; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10012627 chr15:38545011 SPRED1 -0.35 -5.95 -0.31 6.82e-9 Triglycerides; LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg07157834 chr1:205819609 PM20D1 0.75 13.88 0.6 6.43e-35 Monocyte percentage of white cells; LUSC cis rs1670533 1.000 rs604597 chr4:1094151 G/A cg02018176 chr4:1364513 KIAA1530 -0.47 -6.45 -0.33 4.03e-10 Recombination rate (females); LUSC cis rs7169223 0.653 rs8042170 chr15:79096599 G/A cg21242079 chr15:79101063 ADAMTS7 0.39 5.88 0.31 9.81e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9296092 0.538 rs76589475 chr6:33519517 G/C cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.59e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs12681288 0.676 rs2701914 chr8:999935 C/T cg15309053 chr8:964076 NA 0.4 8.05 0.4 1.46e-14 Schizophrenia; LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg13397359 chr6:42928475 GNMT 0.58 9.85 0.47 2.9e-20 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11866815 0.857 rs2361988 chr16:398151 T/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.39 5.97 0.31 6.22e-9 Body mass index; LUSC trans rs11098499 1.000 rs1011054 chr4:120202387 A/G cg25214090 chr10:38739885 LOC399744 -0.46 -6.79 -0.35 5.02e-11 Corneal astigmatism; LUSC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.37 6.07 0.32 3.39e-9 Red blood cell count;Reticulocyte count; LUSC cis rs9527 0.590 rs12785223 chr10:104844011 C/T cg23093090 chr10:104574429 C10orf26 0.37 6.76 0.35 6.35e-11 Arsenic metabolism; LUSC cis rs796364 0.625 rs1369843 chr2:201088171 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.53 6.28 0.32 1.07e-9 Schizophrenia; LUSC cis rs427941 0.610 rs201489 chr7:101749901 C/T cg06246474 chr7:101738831 CUX1 0.39 6.33 0.33 7.88e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg09035930 chr12:129282057 SLC15A4 0.73 16.0 0.66 3.52e-43 Systemic lupus erythematosus; LUSC cis rs9325144 0.600 rs10785615 chr12:38733627 G/C cg13010199 chr12:38710504 ALG10B 0.47 7.34 0.37 1.69e-12 Morning vs. evening chronotype; LUSC cis rs3087591 1.000 rs3087591 chr17:29630970 A/G cg24425628 chr17:29625626 OMG;NF1 -0.6 -8.59 -0.43 3.35e-16 Hip circumference; LUSC cis rs2282300 0.739 rs34234618 chr11:30241701 T/C cg06241208 chr11:30344200 C11orf46 -0.44 -5.65 -0.3 3.52e-8 Morning vs. evening chronotype; LUSC cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg05283184 chr6:79620031 NA -0.45 -8.61 -0.43 2.94e-16 Intelligence (multi-trait analysis); LUSC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg12463550 chr7:65579703 CRCP 0.5 7.25 0.37 2.97e-12 Aortic root size; LUSC cis rs72949976 0.606 rs2178756 chr2:214031423 A/G cg08319019 chr2:214017104 IKZF2 0.67 11.13 0.52 1.08e-24 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.9 0.44 3.69e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg00945038 chr17:61921165 SMARCD2 0.54 9.36 0.46 1.17e-18 Prudent dietary pattern; LUSC cis rs11229555 1.000 rs2275993 chr11:58379987 A/G cg15696309 chr11:58395628 NA -0.69 -9.27 -0.45 2.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs897080 0.515 rs1067359 chr2:44661997 G/T cg00619915 chr2:44497795 NA -0.39 -5.69 -0.3 2.85e-8 Height; LUSC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg04369109 chr6:150039330 LATS1 -0.52 -7.5 -0.38 5.72e-13 Lung cancer; LUSC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg06221963 chr1:154839813 KCNN3 -0.64 -14.79 -0.63 2.03e-38 Prostate cancer; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.71 -11.65 -0.54 1.47e-26 Prudent dietary pattern; LUSC cis rs3008870 1.000 rs2755256 chr1:67471692 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.02 0.63 2.62e-39 Lymphocyte percentage of white cells; LUSC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.89 -0.35 2.72e-11 Lung cancer; LUSC cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.34 0.49 6.29e-22 Drug-induced liver injury (flucloxacillin); LUSC trans rs10838801 1 rs10838801 chr11:48098280 G/A cg15704280 chr7:45808275 SEPT13 -0.62 -8.17 -0.41 6.36e-15 Height; LUSC cis rs540254 0.551 rs2271967 chr1:160787705 T/C cg20255094 chr1:160771763 LY9 0.57 6.79 0.35 5.07e-11 Blood protein levels; LUSC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg18904891 chr8:8559673 CLDN23 0.61 8.43 0.42 1.02e-15 Obesity-related traits; LUSC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg26116260 chr4:7069785 GRPEL1 1.16 18.16 0.7 9.53e-52 Monocyte percentage of white cells; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -5.9 -0.31 9.1e-9 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.875 rs2814866 chr6:146339414 C/A cg23711669 chr6:146136114 FBXO30 0.84 15.05 0.64 1.97e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs1113500 0.614 rs11185243 chr1:108597141 T/C cg06207961 chr1:108661230 NA 0.36 6.04 0.31 4.11e-9 Growth-regulated protein alpha levels; LUSC cis rs10435719 0.899 rs11250177 chr8:11799099 G/A cg21775007 chr8:11205619 TDH 0.46 6.51 0.34 2.72e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg18904891 chr8:8559673 CLDN23 0.61 8.18 0.41 6.04e-15 Obesity-related traits; LUSC cis rs7640424 0.620 rs7637244 chr3:107815763 T/A cg09227934 chr3:107805635 CD47 -0.54 -7.83 -0.39 6.71e-14 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01494303 chr16:3508002 NAT15 -0.44 -6.58 -0.34 1.81e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1712517 0.526 rs113528138 chr10:105125451 C/A cg04362960 chr10:104952993 NT5C2 -0.5 -6.65 -0.34 1.21e-10 Migraine; LUSC cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.7 0.39 1.52e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4803468 1.000 rs284649 chr19:41926838 C/T cg09537434 chr19:41945824 ATP5SL -0.92 -16.09 -0.66 1.58e-43 Height; LUSC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg01579765 chr21:45077557 HSF2BP -0.55 -11.75 -0.54 6.51e-27 Mean corpuscular volume; LUSC cis rs4654899 0.865 rs12130664 chr1:21332812 G/T cg01072550 chr1:21505969 NA -0.5 -7.41 -0.38 1.03e-12 Superior frontal gyrus grey matter volume; LUSC cis rs1322512 0.917 rs2758817 chr6:152973270 G/C cg27316956 chr6:152958899 SYNE1 -0.37 -6.3 -0.33 9.2e-10 Tonometry; LUSC cis rs7180079 1.000 rs1117087 chr15:64598823 T/G cg02848875 chr15:64387786 SNX1 0.41 5.76 0.3 1.95e-8 Monocyte count; LUSC cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg27129171 chr3:47204927 SETD2 -0.68 -11.69 -0.54 1.07e-26 Colorectal cancer; LUSC cis rs997295 0.713 rs8042567 chr15:67975599 G/A cg08079166 chr15:68083412 MAP2K5 -0.33 -6.56 -0.34 2.06e-10 Motion sickness; LUSC cis rs72781680 1.000 rs56068891 chr2:24230633 A/G cg08917208 chr2:24149416 ATAD2B 1.0 10.49 0.5 1.96e-22 Lymphocyte counts; LUSC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.79e-10 Schizophrenia; LUSC cis rs3806843 0.576 rs246027 chr5:140333601 A/G cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11890956 chr21:40555474 PSMG1 -0.75 -11.65 -0.54 1.47e-26 Menarche (age at onset); LUSC cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg24130564 chr14:104152367 KLC1 -0.48 -7.09 -0.36 8.15e-12 Intelligence (multi-trait analysis); LUSC cis rs11776272 0.623 rs11992609 chr8:21895146 C/T cg17168535 chr8:21777572 XPO7 0.48 6.77 0.35 5.8200000000000003e-11 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G ch.1.28801127F chr1:28928540 NA 0.45 6.14 0.32 2.36e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11105298 0.891 rs6538190 chr12:89885942 T/C cg00757033 chr12:89920650 WDR51B 0.6 10.35 0.49 5.9e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg08999081 chr20:33150536 PIGU 0.52 10.29 0.49 9.11e-22 Glomerular filtration rate (creatinine); LUSC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 9.07 0.44 1.02e-17 Mean platelet volume; LUSC cis rs1448094 0.802 rs56391398 chr12:86424114 C/T cg02569458 chr12:86230093 RASSF9 0.41 6.64 0.34 1.25e-10 Major depressive disorder; LUSC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9324022 0.929 rs9635298 chr14:101172542 C/T cg18089426 chr14:101175970 NA 0.48 5.74 0.3 2.1e-8 Plateletcrit; LUSC cis rs1728785 1.000 rs1170434 chr16:68606590 A/G cg02972257 chr16:68554789 NA -0.54 -6.73 -0.35 7.29e-11 Ulcerative colitis; LUSC cis rs13315871 0.932 rs35741271 chr3:58323091 A/G cg20936604 chr3:58311152 NA -0.77 -7.27 -0.37 2.56e-12 Cholesterol, total; LUSC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg19717773 chr7:2847554 GNA12 -0.39 -6.4 -0.33 5.35e-10 Height; LUSC cis rs1595825 0.891 rs77946222 chr2:198533251 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.61 -0.34 1.51e-10 Ulcerative colitis; LUSC cis rs7759001 0.857 rs4713085 chr6:27349964 C/T cg18711553 chr6:27366782 ZNF391 0.4 5.81 0.3 1.48e-8 Glomerular filtration rate (creatinine); LUSC trans rs1728785 0.901 rs1645974 chr16:68564774 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.55 0.38 4.23e-13 Ulcerative colitis; LUSC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.83 -0.3 1.28e-8 Tonsillectomy; LUSC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg16489826 chr6:160211363 TCP1;MRPL18 0.56 7.08 0.36 8.3e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs6494488 0.500 rs55881719 chr15:64714903 T/G cg08069370 chr15:64387884 SNX1 -0.64 -5.67 -0.3 3.05e-8 Coronary artery disease; LUSC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg12639453 chr1:2035780 PRKCZ -0.31 -6.47 -0.33 3.4e-10 Height; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg04267008 chr7:1944627 MAD1L1 -0.6 -9.22 -0.45 3.47e-18 Bipolar disorder and schizophrenia; LUSC trans rs9951602 0.512 rs12607612 chr18:76651799 G/A cg02800362 chr5:177631904 HNRNPAB 0.88 13.16 0.58 3.72e-32 Obesity-related traits; LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg07703079 chr11:430292 ANO9 0.7 7.12 0.36 6.72e-12 Body mass index; LUSC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg26335602 chr6:28129616 ZNF389 0.42 5.7 0.3 2.63e-8 Depression; LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.97 0.4 2.6e-14 Prudent dietary pattern; LUSC cis rs6546537 0.562 rs1985342 chr2:69758927 C/T cg10773587 chr2:69614142 GFPT1 -0.59 -9.74 -0.47 6.99e-20 Serum thyroid-stimulating hormone levels; LUSC cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.21 -0.37 3.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7191439 0.858 rs11076701 chr16:88774525 A/G cg26217441 chr16:89643414 CPNE7 -0.52 -5.68 -0.3 2.93e-8 Plateletcrit; LUSC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg05340658 chr4:99064831 C4orf37 0.63 10.63 0.5 6.2e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6424115 0.867 rs4649119 chr1:24171543 C/G cg10978503 chr1:24200527 CNR2 -0.53 -12.49 -0.56 1.18e-29 Immature fraction of reticulocytes; LUSC cis rs10782582 0.609 rs1498311 chr1:76254726 A/C cg10523679 chr1:76189770 ACADM 0.45 6.44 0.33 4.09e-10 Daytime sleep phenotypes; LUSC cis rs1372520 0.577 rs748849 chr4:90734961 G/A cg15133208 chr4:90757351 SNCA -0.55 -8.64 -0.43 2.31e-16 Neuroticism; LUSC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.62 0.43 2.69e-16 Prudent dietary pattern; LUSC cis rs7917772 0.560 rs35095897 chr10:104377759 T/C cg22532475 chr10:104410764 TRIM8 0.26 6.15 0.32 2.21e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs265548 0.510 rs28415068 chr19:17910582 T/A cg04517722 chr19:17905589 B3GNT3 0.41 6.04 0.31 4.07e-9 Tumor biomarkers; LUSC trans rs2197308 0.765 rs2387436 chr12:37935337 C/T cg06521331 chr12:34319734 NA 0.41 6.45 0.33 3.83e-10 Morning vs. evening chronotype; LUSC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg20891283 chr12:69753455 YEATS4 0.66 10.32 0.49 7.26e-22 Blood protein levels; LUSC cis rs2708377 0.860 rs2597975 chr12:11252797 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs1784581 0.588 rs9458428 chr6:162424579 A/G cg17173639 chr6:162384350 PARK2 -0.57 -9.9 -0.48 1.98e-20 Itch intensity from mosquito bite; LUSC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.11 0.36 7.01e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2290416 0.892 rs62522165 chr8:144675379 C/T cg26536354 chr8:144654954 C8orf73 0.65 7.23 0.37 3.27e-12 Attention deficit hyperactivity disorder; LUSC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg03929089 chr4:120376271 NA 0.94 15.17 0.64 6.65e-40 Coronary artery disease; LUSC cis rs9814567 0.964 rs9815983 chr3:134222507 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.79 -0.6 1.45e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs12188164 0.965 rs11743639 chr5:450710 C/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs7759001 0.857 rs4713084 chr6:27349863 G/A cg18711553 chr6:27366782 ZNF391 0.4 5.81 0.3 1.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs7937682 0.632 rs3944619 chr11:111774743 A/G cg09085632 chr11:111637200 PPP2R1B 0.93 12.58 0.57 5.56e-30 Primary sclerosing cholangitis; LUSC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg15839431 chr19:19639596 YJEFN3 -0.57 -6.87 -0.35 3.12e-11 Bipolar disorder; LUSC cis rs10876993 0.821 rs1678522 chr12:58049923 G/A cg18357645 chr12:58087776 OS9 0.51 7.6 0.38 3.05e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs6601450 0.579 rs11775625 chr8:10272439 C/T cg12940923 chr8:10282607 MSRA 0.35 6.7 0.34 8.61e-11 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg09365446 chr1:150670422 GOLPH3L 0.52 7.97 0.4 2.52e-14 Tonsillectomy; LUSC cis rs12579753 1.000 rs12827923 chr12:82242067 G/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs6756513 0.501 rs7581977 chr2:70174054 C/T cg02498382 chr2:70120550 SNRNP27 0.26 6.47 0.33 3.48e-10 Breast cancer;Platelet count; LUSC cis rs926938 0.527 rs360670 chr1:115482386 G/A cg12756093 chr1:115239321 AMPD1 0.47 7.19 0.37 4.19e-12 Autism; LUSC cis rs3540 0.574 rs2657947 chr15:90968977 C/T cg03599575 chr15:90893182 GABARAPL3 -0.33 -5.82 -0.3 1.41e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs9467711 0.606 rs9379851 chr6:26354780 A/C cg09904177 chr6:26538194 HMGN4 -0.64 -6.38 -0.33 5.78e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs12594515 1.000 rs8043291 chr15:45996247 T/A cg19682013 chr15:45996608 NA 0.39 5.8 0.3 1.51e-8 Waist circumference;Weight; LUSC cis rs7223966 1.000 rs6504171 chr17:61710010 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.44 0.38 8.69e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs12493885 0.818 rs7641039 chr3:153768638 A/C cg17054900 chr3:154042577 DHX36 0.51 5.85 0.3 1.18e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs7939886 0.920 rs77344682 chr11:55999358 A/G cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg06462663 chr19:18546047 ISYNA1 0.47 8.02 0.4 1.76e-14 Breast cancer; LUSC cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg04450456 chr4:17643702 FAM184B -0.4 -6.61 -0.34 1.57e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg20744362 chr22:50050164 C22orf34 0.4 8.24 0.41 3.94e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1832871 0.672 rs9457361 chr6:158771750 G/A cg07165851 chr6:158734300 TULP4 0.47 7.08 0.36 8.77e-12 Height; LUSC cis rs17253792 0.687 rs10137995 chr14:56173687 A/G cg01858014 chr14:56050164 KTN1 -0.58 -5.71 -0.3 2.43e-8 Putamen volume; LUSC cis rs11023332 0.617 rs1879888 chr11:14679247 A/G cg19336497 chr11:14380999 RRAS2 -0.32 -6.02 -0.31 4.58e-9 Adiponectin levels;Vitamin D levels; LUSC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg25456477 chr12:86230367 RASSF9 0.39 6.88 0.35 2.96e-11 Major depressive disorder; LUSC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg17971929 chr21:40555470 PSMG1 0.79 13.99 0.61 2.52e-35 Cognitive function; LUSC cis rs2267137 0.776 rs2267145 chr22:29805407 C/T cg07256473 chr22:29710276 RASL10A -0.37 -7.32 -0.37 1.83e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs858239 0.600 rs10233039 chr7:23143113 G/A cg05407003 chr7:23246146 NA -0.39 -5.73 -0.3 2.21e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg17892150 chr10:133769511 PPP2R2D -0.66 -9.22 -0.45 3.51e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg23758822 chr17:41437982 NA 1.01 19.41 0.73 9.83e-57 Menopause (age at onset); LUSC cis rs17685 0.712 rs4732578 chr7:75721532 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.69 -0.39 1.68e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs3770081 1.000 rs77309268 chr2:86293294 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC cis rs1801251 1.000 rs35085837 chr2:233624363 A/G cg25237894 chr2:233734115 C2orf82 0.36 6.74 0.35 7.17e-11 Coronary artery disease; LUSC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg24296786 chr1:45957014 TESK2 0.49 7.19 0.37 4.16e-12 High light scatter reticulocyte count; LUSC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg24399712 chr22:39784796 NA -0.65 -11.99 -0.55 8.41e-28 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs11190551 chr10:102204734 A/G cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg19680485 chr15:31195859 MTMR15 0.49 6.54 0.34 2.31e-10 Huntington's disease progression; LUSC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.45 -0.33 3.85e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9549367 0.774 rs9549696 chr13:113875062 C/T cg18105134 chr13:113819100 PROZ -0.74 -10.88 -0.51 8.18e-24 Platelet distribution width; LUSC cis rs5769707 0.605 rs6009791 chr22:50025265 T/C cg10356904 chr22:49881777 NA -0.29 -5.82 -0.3 1.39e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1048238 0.545 rs848199 chr1:16292742 C/T cg22431228 chr1:16359049 CLCNKA 0.4 8.32 0.41 2.3e-15 Systolic blood pressure; LUSC cis rs6840360 0.571 rs7695866 chr4:152488110 G/A cg22705602 chr4:152727874 NA -0.34 -6.92 -0.35 2.27e-11 Intelligence (multi-trait analysis); LUSC cis rs35146811 0.735 rs1727138 chr7:99815247 A/G cg22906224 chr7:99728672 NA -0.47 -6.59 -0.34 1.67e-10 Coronary artery disease; LUSC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg20476274 chr7:133979776 SLC35B4 0.8 14.15 0.61 6.06e-36 Mean platelet volume; LUSC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg26587870 chr6:27730563 NA -0.66 -5.92 -0.31 8.07e-9 Depression; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15816013 chr14:102606074 WDR20;HSP90AA1 -0.41 -6.07 -0.32 3.48e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg20503657 chr10:835505 NA 1.21 16.39 0.67 1.07e-44 Eosinophil percentage of granulocytes; LUSC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg18758796 chr5:131593413 PDLIM4 0.43 7.41 0.38 1.06e-12 Breast cancer; LUSC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.41 -0.33 5.09e-10 Total body bone mineral density; LUSC cis rs1729951 0.546 rs835634 chr3:136676303 C/T cg21827317 chr3:136751795 NA 0.39 6.92 0.35 2.25e-11 Neuroticism; LUSC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg10130564 chr11:117069849 TAGLN 0.37 6.68 0.34 9.73e-11 Blood protein levels; LUSC cis rs7103648 0.669 rs11039332 chr11:47695840 G/A cg20307385 chr11:47447363 PSMC3 0.81 12.57 0.57 5.97e-30 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg04025307 chr7:1156635 C7orf50 0.52 8.43 0.42 1.07e-15 Longevity;Endometriosis; LUSC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.83 0.39 6.53e-14 Blood metabolite levels; LUSC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.64 -0.39 2.31e-13 Personality dimensions; LUSC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg06494592 chr3:125709126 NA -0.51 -6.16 -0.32 2.06e-9 Blood pressure (smoking interaction); LUSC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg02187348 chr16:89574699 SPG7 0.48 7.41 0.38 1.06e-12 Multiple myeloma (IgH translocation); LUSC cis rs7180079 0.620 rs8036775 chr15:64844372 G/T cg08069370 chr15:64387884 SNX1 -0.52 -5.76 -0.3 1.87e-8 Monocyte count; LUSC cis rs2249625 0.564 rs2496496 chr6:72884053 A/G cg18830697 chr6:72922368 RIMS1 -0.37 -7.38 -0.37 1.25e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs6669072 0.647 rs1335727 chr1:91238652 C/T cg08895590 chr1:91227319 NA -0.39 -8.84 -0.44 5.45e-17 Cognitive function; LUSC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg12564285 chr5:131593104 PDLIM4 0.42 7.55 0.38 4.1e-13 Breast cancer; LUSC cis rs11105298 0.891 rs10858871 chr12:89871613 G/A cg00757033 chr12:89920650 WDR51B 0.6 10.33 0.49 7.01e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7909074 1.000 rs10736831 chr10:45402311 G/A cg04218760 chr10:45406644 TMEM72 -0.29 -7.05 -0.36 1.03e-11 Mean corpuscular volume; LUSC cis rs146201400 1 rs146201400 chr1:26645955 G/GA cg00852783 chr1:26633632 UBXN11 0.6 8.97 0.44 2.16e-17 Monocyte percentage of white cells; LUSC cis rs2667011 0.503 rs3792165 chr2:160837369 G/A cg06573604 chr2:160760825 LY75 -0.48 -7.2 -0.37 3.99e-12 Bilirubin levels; LUSC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.62 9.46 0.46 5.51e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg01475377 chr6:109611718 NA -0.45 -8.27 -0.41 3.26e-15 Reticulocyte fraction of red cells; LUSC cis rs9325144 0.647 rs3759139 chr12:39087609 G/A cg13010199 chr12:38710504 ALG10B -0.51 -7.73 -0.39 1.3e-13 Morning vs. evening chronotype; LUSC cis rs7107174 1.000 rs11237469 chr11:78072875 A/T cg02023728 chr11:77925099 USP35 0.49 7.02 0.36 1.24e-11 Testicular germ cell tumor; LUSC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg12311346 chr5:56204834 C5orf35 -0.95 -13.07 -0.58 8.13e-32 Initial pursuit acceleration; LUSC cis rs116988415 0.584 rs4902314 chr14:65254415 T/C cg00114569 chr14:65239327 SPTB 0.68 7.16 0.36 5.31e-12 Daytime sleep phenotypes; LUSC cis rs3020736 0.500 rs8138678 chr22:42516229 A/G cg05082376 chr22:42548792 NA 0.43 6.59 0.34 1.67e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg20503657 chr10:835505 NA 0.96 13.38 0.59 5.31e-33 Eosinophil percentage of granulocytes; LUSC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg18306943 chr3:40428807 ENTPD3 0.37 5.98 0.31 5.69e-9 Renal cell carcinoma; LUSC cis rs2200578 0.786 rs62158261 chr2:99563210 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.33 0.33 7.95e-10 IgG glycosylation; LUSC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg07701084 chr6:150067640 NUP43 0.57 8.74 0.43 1.16e-16 Lung cancer; LUSC cis rs7241530 0.662 rs924889 chr18:75900770 A/G cg14642773 chr18:75888474 NA 0.4 5.97 0.31 6.06e-9 Educational attainment (years of education); LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg18404041 chr3:52824283 ITIH1 -0.58 -11.27 -0.52 3.48e-25 Bipolar disorder; LUSC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.47e-8 Extrinsic epigenetic age acceleration; LUSC cis rs807669 1.000 rs807670 chr22:19154608 A/C cg02655711 chr22:19163373 SLC25A1 0.67 12.48 0.56 1.31e-29 Metabolite levels; LUSC cis rs7771547 0.519 rs58153398 chr6:36370394 A/C cg07856975 chr6:36356162 ETV7 0.44 6.51 0.34 2.83e-10 Platelet distribution width; LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg23758822 chr17:41437982 NA 1.04 19.91 0.74 1.09e-58 Menopause (age at onset); LUSC cis rs11098499 0.913 rs10006304 chr4:120124305 A/G cg24375607 chr4:120327624 NA 0.73 10.75 0.51 2.35e-23 Corneal astigmatism; LUSC cis rs12681287 0.547 rs7459877 chr8:87505660 G/A cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg06112835 chr11:68658793 MRPL21 0.52 8.07 0.4 1.29e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg12705353 chr12:122356852 WDR66 0.39 5.75 0.3 2.06e-8 Mean platelet volume; LUSC cis rs10752881 0.901 rs10911201 chr1:183001622 G/T ch.1.3577855R chr1:183094577 LAMC1 0.71 11.02 0.52 2.78e-24 Colorectal cancer; LUSC cis rs7927592 0.830 rs10896339 chr11:68302846 G/C cg20283391 chr11:68216788 NA -0.57 -8.08 -0.4 1.16e-14 Total body bone mineral density; LUSC cis rs9469578 1.000 rs9469581 chr6:33715904 C/A cg18708504 chr6:33715942 IP6K3 0.7 8.84 0.44 5.53e-17 Phosphorus levels; LUSC cis rs4780401 0.609 rs35902600 chr16:11800848 C/T cg01061890 chr16:11836724 TXNDC11 -0.56 -8.58 -0.42 3.75e-16 Rheumatoid arthritis; LUSC cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg10172584 chr19:19639581 YJEFN3 0.49 5.8 0.3 1.5e-8 Bipolar disorder; LUSC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg09491104 chr22:46646882 C22orf40 -0.73 -6.61 -0.34 1.56e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -6.1 -0.32 2.9e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg06850241 chr22:41845214 NA 0.34 6.3 0.33 9.5e-10 Vitiligo; LUSC cis rs11190604 1.000 rs10883507 chr10:102291275 C/T cg23241863 chr10:102295624 HIF1AN 0.48 5.74 0.3 2.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg06060754 chr5:176797920 RGS14 -0.61 -9.06 -0.44 1.1e-17 Urate levels in lean individuals; LUSC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg06481639 chr22:41940642 POLR3H 0.51 5.82 0.3 1.39e-8 Vitiligo; LUSC trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg03929089 chr4:120376271 NA -0.76 -10.26 -0.49 1.19e-21 Coronary artery disease; LUSC cis rs4363385 0.818 rs454993 chr1:153008992 C/G cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC trans rs3808502 0.549 rs4841564 chr8:11425809 T/G cg08975724 chr8:8085496 FLJ10661 -0.48 -6.78 -0.35 5.39e-11 Neuroticism; LUSC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg03732007 chr1:2071316 PRKCZ 0.6 11.24 0.52 4.53e-25 Height; LUSC cis rs7202877 0.610 rs3784936 chr16:75337583 C/G cg03315344 chr16:75512273 CHST6 0.46 6.27 0.32 1.09e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs2797160 1.000 rs77678056 chr6:126019738 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.86 0.35 3.43e-11 Endometrial cancer; LUSC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg22549504 chr19:17448937 GTPBP3 0.54 6.7 0.34 8.78e-11 Systemic lupus erythematosus; LUSC cis rs9314323 0.862 rs3808580 chr8:26250296 C/T cg11498726 chr8:26250323 BNIP3L 0.46 6.74 0.35 7.08e-11 Red cell distribution width; LUSC trans rs6445975 0.666 rs9822328 chr3:58407837 T/C cg18950693 chr14:70346909 SMOC1 -0.4 -6.06 -0.31 3.75e-9 Systemic lupus erythematosus; LUSC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.76 10.89 0.51 7.73e-24 Cognitive test performance; LUSC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg17554472 chr22:41940697 POLR3H 0.48 5.91 0.31 8.32e-9 Vitiligo; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06268701 chr1:110091083 GNAI3 -0.39 -5.99 -0.31 5.34e-9 Electrocardiographic conduction measures; LUSC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg15704280 chr7:45808275 SEPT13 1.02 17.49 0.69 4.44e-49 Coronary artery disease; LUSC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg24549020 chr5:56110836 MAP3K1 -0.44 -5.88 -0.31 9.82e-9 Initial pursuit acceleration; LUSC cis rs754466 0.651 rs11813532 chr10:79637991 T/C cg17075019 chr10:79541650 NA -0.76 -12.22 -0.56 1.18e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11051970 1.000 rs1872829 chr12:32535100 C/T cg24626660 chr12:32551988 NA 0.4 6.75 0.35 6.62e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg14196790 chr5:131705035 SLC22A5 0.41 6.95 0.36 1.98e-11 Breast cancer;Mosquito bite size; LUSC cis rs61863818 0.533 rs954148 chr10:99123006 T/C cg20016023 chr10:99160130 RRP12 -0.27 -6.63 -0.34 1.33e-10 Monocyte percentage of white cells; LUSC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 7.78 0.39 9.16e-14 Autism spectrum disorder or schizophrenia; LUSC trans rs6952808 0.575 rs6950330 chr7:1953606 T/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.37 0.33 6.41e-10 Bipolar disorder and schizophrenia; LUSC cis rs72781680 0.898 rs72780191 chr2:24007122 T/C cg20701182 chr2:24300061 SF3B14 0.73 7.39 0.37 1.2e-12 Lymphocyte counts; LUSC cis rs4295623 0.504 rs11250160 chr8:11592717 G/A cg21775007 chr8:11205619 TDH -0.48 -6.9 -0.35 2.56e-11 Morning vs. evening chronotype; LUSC cis rs3733418 1.000 rs3733419 chr4:165878170 A/G cg25904183 chr4:165877875 C4orf39;TRIM61 -0.46 -6.1 -0.32 2.98e-9 Obesity-related traits; LUSC cis rs2573652 0.722 rs11852383 chr15:100542765 C/T cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.51 -0.34 2.74e-10 Height; LUSC cis rs9457247 1.000 rs10946199 chr6:167404492 G/A cg07741184 chr6:167504864 NA 0.36 6.5 0.34 2.9e-10 Crohn's disease; LUSC cis rs11756438 0.572 rs2798326 chr6:119005226 C/T cg18833306 chr6:118973337 C6orf204 0.36 5.82 0.3 1.39e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9527 0.590 rs10883829 chr10:104840635 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.52 0.46 3.52e-19 Arsenic metabolism; LUSC trans rs11039798 1.000 rs34044596 chr11:48527936 T/C cg03929089 chr4:120376271 NA 0.64 5.99 0.31 5.58e-9 Axial length; LUSC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.8e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs72949976 0.966 rs6752061 chr2:214027818 C/T cg08319019 chr2:214017104 IKZF2 -0.64 -9.95 -0.48 1.39e-20 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs6964587 1.000 rs12333563 chr7:91667326 G/A cg17063962 chr7:91808500 NA 0.58 9.29 0.45 2.01e-18 Breast cancer; LUSC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg08917208 chr2:24149416 ATAD2B 0.53 5.87 0.31 1.03e-8 Lymphocyte counts; LUSC cis rs9303401 0.659 rs35828828 chr17:56718205 C/T cg25039879 chr17:56429692 SUPT4H1 0.64 8.72 0.43 1.33e-16 Cognitive test performance; LUSC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.37e-34 Diabetic kidney disease; LUSC cis rs6542838 0.641 rs10192266 chr2:99521837 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.54 -7.37 -0.37 1.38e-12 Fear of minor pain; LUSC trans rs62103177 0.810 rs62103195 chr18:77629693 T/C cg05926928 chr17:57297772 GDPD1 1.51 17.05 0.68 2.46e-47 Opioid sensitivity; LUSC cis rs8072100 0.805 rs67919208 chr17:45771873 T/C cg08085267 chr17:45401833 C17orf57 -0.5 -8.01 -0.4 1.99e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6961069 0.708 rs10240336 chr7:80218674 T/C cg04458919 chr7:80252533 CD36 -0.4 -7.0 -0.36 1.41e-11 Platelet count; LUSC cis rs12458462 0.851 rs2169249 chr18:77489649 G/A cg11879182 chr18:77439856 CTDP1 0.69 10.4 0.49 4.09e-22 Monocyte count; LUSC cis rs68170813 0.652 rs6947674 chr7:107193504 T/C cg02696742 chr7:106810147 HBP1 -0.62 -8.31 -0.41 2.42e-15 Coronary artery disease; LUSC cis rs644799 0.582 rs1727149 chr11:95497171 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.78 -11.66 -0.54 1.4e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg18404041 chr3:52824283 ITIH1 -0.6 -11.57 -0.53 2.91e-26 Bipolar disorder; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg04267008 chr7:1944627 MAD1L1 -0.55 -8.35 -0.42 1.78e-15 Bipolar disorder and schizophrenia; LUSC cis rs12893668 0.673 rs2296482 chr14:104029819 T/G cg04998671 chr14:104000505 TRMT61A -0.45 -6.26 -0.32 1.17e-9 Reticulocyte count; LUSC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg13390004 chr1:15929781 NA 0.39 6.64 0.34 1.28e-10 Systolic blood pressure; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg06145435 chr7:1022769 CYP2W1 0.3 6.21 0.32 1.56e-9 Longevity;Endometriosis; LUSC cis rs243505 1.000 rs243522 chr7:148420509 A/G cg09806900 chr7:148480153 CUL1 -0.48 -6.94 -0.35 2.08e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs500891 0.547 rs12191369 chr6:84102550 A/C cg08257003 chr6:84140564 ME1 0.32 7.26 0.37 2.82e-12 Platelet-derived growth factor BB levels; LUSC cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs936229 0.690 rs2472300 chr15:75033909 A/G cg14664628 chr15:75095509 CSK -0.85 -13.63 -0.6 6.18e-34 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg11764359 chr7:65958608 NA -0.77 -12.47 -0.56 1.44e-29 Aortic root size; LUSC cis rs2070488 0.745 rs9838792 chr3:38546726 G/A cg24069376 chr3:38537580 EXOG -0.39 -7.61 -0.38 2.84e-13 Electrocardiographic conduction measures; LUSC cis rs72634258 0.786 rs6682709 chr1:8173796 A/C cg00042356 chr1:8021962 PARK7 -0.53 -6.4 -0.33 5.31e-10 Inflammatory bowel disease; LUSC cis rs12367572 1.000 rs10880704 chr12:45318430 C/T cg04608330 chr12:45269318 NELL2 -0.56 -8.87 -0.44 4.65e-17 Gut microbiome composition (summer); LUSC cis rs13394619 0.655 rs7578132 chr2:11718858 C/T cg07314298 chr2:11723111 GREB1 -0.46 -7.45 -0.38 8.05e-13 Endometriosis; LUSC trans rs475616 0.959 rs1360550 chr10:30487760 G/A cg02841571 chr6:169977833 WDR27 0.42 6.14 0.32 2.33e-9 Monocyte count; LUSC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11644478 chr21:40555479 PSMG1 0.92 18.06 0.7 2.35e-51 Cognitive function; LUSC cis rs4776059 0.798 rs58018557 chr15:52901284 T/C cg22715398 chr15:52968154 KIAA1370 0.69 9.08 0.44 9.74e-18 Schizophrenia; LUSC trans rs656319 0.669 rs56279061 chr8:9873980 T/C cg21775007 chr8:11205619 TDH -0.47 -6.53 -0.34 2.44e-10 Myopia (pathological); LUSC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg26380479 chr7:97908229 NA -0.28 -6.13 -0.32 2.47e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7264396 0.943 rs224431 chr20:34153599 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.19 -0.37 4.16e-12 Total cholesterol levels; LUSC cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg13010199 chr12:38710504 ALG10B -0.67 -11.21 -0.52 5.48e-25 Heart rate; LUSC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg15147215 chr3:52552868 STAB1 -0.3 -5.84 -0.3 1.24e-8 Electroencephalogram traits; LUSC cis rs1559088 0.948 rs2019603 chr19:33577367 C/T cg17764715 chr19:33622953 WDR88 -0.58 -8.14 -0.41 7.69e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7582720 1.000 rs72928605 chr2:203832120 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.23 0.41 4.13e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1775715 0.675 rs2808085 chr10:32148599 C/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.6e-9 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7769051 1.000 rs9493454 chr6:133144629 G/T cg27275811 chr11:74457193 NA 0.61 6.0 0.31 5.02e-9 Type 2 diabetes nephropathy; LUSC cis rs66887589 0.616 rs7659403 chr4:120207254 T/A cg09307838 chr4:120376055 NA 0.5 7.5 0.38 5.8e-13 Diastolic blood pressure; LUSC cis rs7605827 0.930 rs2380652 chr2:15594926 T/C cg19274914 chr2:15703543 NA 0.46 8.76 0.43 1e-16 Educational attainment (years of education); LUSC cis rs400736 0.729 rs2493216 chr1:8008366 C/A cg25007680 chr1:8021821 PARK7 -0.5 -7.36 -0.37 1.44e-12 Response to antidepressants and depression; LUSC cis rs7789940 0.810 rs12533978 chr7:75943352 T/C cg15798862 chr7:76129360 DTX2 -0.47 -7.67 -0.39 1.92e-13 Multiple sclerosis; LUSC cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg08677398 chr8:58056175 NA -0.57 -6.94 -0.36 2.04e-11 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.18 0.77 1.27e-67 Prudent dietary pattern; LUSC cis rs2880765 0.835 rs4842884 chr15:86035174 T/C cg13263323 chr15:86062960 AKAP13 -0.35 -5.72 -0.3 2.42e-8 Coronary artery disease; LUSC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.26 0.52 3.75e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg06287003 chr12:125626642 AACS -0.39 -6.39 -0.33 5.59e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg06064525 chr11:970664 AP2A2 -0.48 -10.63 -0.5 6.1e-23 Alzheimer's disease (late onset); LUSC cis rs9677476 0.909 rs7573577 chr2:232104079 C/T cg07929768 chr2:232055508 NA 0.35 6.49 0.33 3.16e-10 Food antigen IgG levels; LUSC cis rs765787 0.530 rs4774550 chr15:45542312 C/T cg25801113 chr15:45476975 SHF 0.34 7.12 0.36 6.56e-12 Uric acid levels; LUSC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg06671706 chr8:8559999 CLDN23 0.51 6.91 0.35 2.45e-11 Obesity-related traits; LUSC cis rs7584330 0.868 rs13408361 chr2:238382899 A/G cg16989719 chr2:238392110 NA -0.36 -5.9 -0.31 9.01e-9 Prostate cancer; LUSC cis rs6704644 0.719 rs3768802 chr2:234373725 G/A cg05711037 chr2:234359783 DGKD 0.68 6.41 0.33 5.01e-10 Bilirubin levels; LUSC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg13902645 chr11:5959945 NA -0.57 -7.94 -0.4 3.17e-14 DNA methylation (variation); LUSC cis rs1983891 0.955 rs4714479 chr6:41518807 A/G cg20194872 chr6:41519635 FOXP4 0.34 5.97 0.31 5.96e-9 Prostate cancer; LUSC trans rs656319 0.605 rs60278284 chr8:10003210 G/C cg15556689 chr8:8085844 FLJ10661 -0.52 -7.47 -0.38 7.21e-13 Myopia (pathological); LUSC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg13393036 chr8:95962371 TP53INP1 -0.45 -9.38 -0.46 1.02e-18 Type 2 diabetes; LUSC cis rs17102423 0.723 rs8181938 chr14:65555712 A/G cg11161011 chr14:65562177 MAX -0.81 -12.4 -0.56 2.58e-29 Obesity-related traits; LUSC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg13206674 chr6:150067644 NUP43 0.57 8.93 0.44 2.85e-17 Lung cancer; LUSC cis rs7614311 0.636 rs73130576 chr3:63890875 T/C cg22134162 chr3:63841271 THOC7 -0.48 -6.13 -0.32 2.43e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs6964587 1.000 rs12666179 chr7:91574110 T/C cg01689657 chr7:91764605 CYP51A1 -0.32 -5.88 -0.31 9.85e-9 Breast cancer; LUSC cis rs6987853 0.563 rs2923406 chr8:42448873 G/T cg09913449 chr8:42400586 C8orf40 0.43 7.11 0.36 7.1e-12 Mean corpuscular hemoglobin concentration; LUSC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg13319975 chr6:146136371 FBXO30 -0.53 -8.1 -0.41 1.06e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg03806693 chr22:41940476 POLR3H 1.03 14.29 0.62 1.71e-36 Cannabis dependence symptom count; LUSC trans rs28541881 0.536 rs7247747 chr19:34787144 G/C cg00351152 chr3:12837017 CAND2 -0.66 -5.99 -0.31 5.49e-9 Colorectal cancer; LUSC cis rs9359856 0.518 rs72929359 chr6:90260111 A/G cg13799429 chr6:90582589 CASP8AP2 -0.6 -6.23 -0.32 1.42e-9 Bipolar disorder; LUSC cis rs2980439 0.557 rs2976876 chr8:8318850 T/C cg08975724 chr8:8085496 FLJ10661 0.53 8.0 0.4 2.05e-14 Neuroticism; LUSC cis rs68170813 0.617 rs76923959 chr7:107182915 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg24838063 chr12:130822603 PIWIL1 0.7 10.93 0.51 5.55e-24 Menopause (age at onset); LUSC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg01073479 chr16:3509474 NAT15 -0.4 -5.76 -0.3 1.9e-8 Tuberculosis; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg01335785 chr19:7505029 ARHGEF18 -0.47 -7.33 -0.37 1.72e-12 N-glycan levels; LUSC cis rs6847149 0.759 rs13117220 chr4:110811575 A/G cg07850274 chr4:110748770 RRH 0.52 7.29 0.37 2.31e-12 Exercise treadmill test traits; LUSC cis rs9325144 0.513 rs12313652 chr12:38665412 G/A cg26384229 chr12:38710491 ALG10B -0.66 -10.27 -0.49 1.11e-21 Morning vs. evening chronotype; LUSC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg19046167 chr17:80928561 B3GNTL1 0.45 6.48 0.33 3.2e-10 Glycated hemoglobin levels; LUSC cis rs4253772 0.678 rs1053332 chr22:46640179 A/G cg24881330 chr22:46731750 TRMU 0.68 8.04 0.4 1.61e-14 LDL cholesterol;Cholesterol, total; LUSC cis rs3772130 0.924 rs55643643 chr3:121440197 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.64 9.06 0.44 1.15e-17 Cognitive performance; LUSC cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg04756594 chr16:24857601 SLC5A11 0.35 5.77 0.3 1.81e-8 Intelligence (multi-trait analysis); LUSC cis rs11785400 0.793 rs7459963 chr8:143737129 C/T cg10596483 chr8:143751796 JRK 0.52 7.52 0.38 5.15e-13 Schizophrenia; LUSC cis rs61931739 0.612 rs1906137 chr12:33939676 T/A cg06521331 chr12:34319734 NA -0.41 -6.71 -0.34 8.31e-11 Morning vs. evening chronotype; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg11965913 chr1:205819406 PM20D1 0.9 17.65 0.69 9.91e-50 Menarche (age at onset); LUSC cis rs62400317 0.762 rs6908606 chr6:44998888 A/G cg20913747 chr6:44695427 NA -0.45 -7.12 -0.36 6.8e-12 Total body bone mineral density; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.93 -0.4 3.38e-14 Lymphocyte counts; LUSC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.46 6.93 0.35 2.2e-11 Total body bone mineral density; LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs9733 0.680 rs3738484 chr1:150552330 G/T cg04414720 chr1:150670196 GOLPH3L -0.41 -6.27 -0.32 1.14e-9 Tonsillectomy; LUSC cis rs7674212 0.570 rs2711899 chr4:104062414 T/C cg16532752 chr4:104119610 CENPE -0.5 -7.17 -0.37 4.8e-12 Type 2 diabetes; LUSC cis rs611744 0.647 rs1609472 chr8:109269232 T/G cg18478394 chr8:109455254 TTC35 0.42 6.57 0.34 1.93e-10 Dupuytren's disease; LUSC cis rs911119 0.955 rs2067488 chr20:23594331 T/G cg16589663 chr20:23618590 CST3 0.56 6.77 0.35 5.8200000000000003e-11 Chronic kidney disease; LUSC cis rs17401966 0.540 rs6682868 chr1:10454773 C/T cg19773385 chr1:10388646 KIF1B 0.39 6.84 0.35 3.73e-11 Hepatocellular carcinoma; LUSC cis rs2840044 1.000 rs11080357 chr17:33898933 G/A cg05299278 chr17:33885742 SLFN14 -0.31 -6.38 -0.33 5.88e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg17376030 chr22:41985996 PMM1 0.46 5.87 0.31 1.07e-8 Vitiligo; LUSC cis rs9467773 0.584 rs1021372 chr6:26632444 T/C cg11502198 chr6:26597334 ABT1 0.71 12.06 0.55 4.63e-28 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.506 rs6993610 chr8:10330994 C/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.52 -0.34 2.57e-10 Neuroticism; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg20887711 chr4:1340912 KIAA1530 0.45 6.75 0.35 6.74e-11 Obesity-related traits; LUSC cis rs2369473 1 rs2369473 chr1:160210727 C/A cg07195126 chr1:160370843 VANGL2 0.49 7.58 0.38 3.36e-13 Squamous cell lung carcinoma; LUSC cis rs9815354 0.951 rs6793520 chr3:41865289 C/G cg03022575 chr3:42003672 ULK4 0.59 6.55 0.34 2.2e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs4665630 0.614 rs6739646 chr2:23946840 A/C cg08063864 chr2:24346004 PFN4;LOC375190 -0.81 -7.25 -0.37 2.87e-12 Hypertension; LUSC cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.74 0.51 2.65e-23 Bladder cancer; LUSC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg04315214 chr1:2043799 PRKCZ -0.38 -7.51 -0.38 5.41e-13 Height; LUSC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769707 0.967 rs2071904 chr22:50034477 C/T cg20744362 chr22:50050164 C22orf34 0.4 8.37 0.42 1.64e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg07677032 chr17:61819896 STRADA 0.54 8.94 0.44 2.71e-17 Prudent dietary pattern; LUSC cis rs1322512 0.917 rs1727047 chr6:152942610 T/A cg27316956 chr6:152958899 SYNE1 -0.35 -5.77 -0.3 1.77e-8 Tonometry; LUSC cis rs921968 0.548 rs13427522 chr2:219438359 C/T cg02176678 chr2:219576539 TTLL4 0.64 11.85 0.54 2.83e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs17286411 0.750 rs4788561 chr16:71878255 G/A cg03805757 chr16:71968109 PKD1L3 0.41 6.76 0.35 6.12e-11 Blood protein levels; LUSC cis rs360798 0.532 rs189671 chr2:62959308 T/A cg17519650 chr2:63277830 OTX1 -0.51 -7.17 -0.37 4.85e-12 Coronary artery disease; LUSC cis rs8044995 0.563 rs7190134 chr16:68381516 A/G cg05110241 chr16:68378359 PRMT7 0.83 9.32 0.45 1.66e-18 Schizophrenia; LUSC cis rs826838 0.616 rs4619214 chr12:38614704 C/A cg26384229 chr12:38710491 ALG10B 0.59 8.84 0.44 5.5e-17 Heart rate; LUSC cis rs7247513 1.000 rs12459123 chr19:12689741 T/C cg01871581 chr19:12707946 ZNF490 -0.57 -8.68 -0.43 1.73e-16 Bipolar disorder; LUSC cis rs9650657 0.737 rs4504595 chr8:10655505 A/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.88 -0.31 1.01e-8 Neuroticism; LUSC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg14552801 chr7:65878734 NA 0.38 6.02 0.31 4.53e-9 Aortic root size; LUSC cis rs909002 0.800 rs2176807 chr1:32092735 T/G cg01639898 chr1:32083012 HCRTR1 0.31 7.46 0.38 7.66e-13 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.931 rs2384275 chr10:35297142 A/G cg03585969 chr10:35415529 CREM 0.61 8.94 0.44 2.75e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1559088 1.000 rs12979164 chr19:33553228 G/C cg03563238 chr19:33554763 RHPN2 -0.41 -6.63 -0.34 1.35e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3126085 1.000 rs12567463 chr1:152180128 T/A cg26876637 chr1:152193138 HRNR -0.41 -5.66 -0.3 3.3e-8 Atopic dermatitis; LUSC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg09703963 chr11:616879 IRF7;MUPCDH -0.37 -6.08 -0.32 3.3e-9 Systemic lupus erythematosus; LUSC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.24 0.41 3.95e-15 Melanoma; LUSC cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs72781680 0.898 rs12619592 chr2:23971415 C/A cg20701182 chr2:24300061 SF3B14 0.55 5.85 0.3 1.2e-8 Lymphocyte counts; LUSC cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs3764563 1.000 rs11673070 chr19:15746095 A/G cg20725493 chr19:15740067 CYP4F8 -0.64 -6.54 -0.34 2.35e-10 Inflammatory biomarkers; LUSC cis rs7917772 0.604 rs10883756 chr10:104400112 T/C cg05855489 chr10:104503620 C10orf26 0.42 5.74 0.3 2.09e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7208859 0.673 rs9915963 chr17:29019643 C/T cg13385521 chr17:29058706 SUZ12P 0.58 5.98 0.31 5.68e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs861020 0.630 rs592694 chr1:210009533 G/T cg05527609 chr1:210001259 C1orf107 0.68 9.89 0.48 2.18e-20 Orofacial clefts; LUSC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg18681998 chr4:17616180 MED28 0.84 15.29 0.64 2.27e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs3960554 0.867 rs79359354 chr7:75702597 G/A cg19862616 chr7:65841803 NCRNA00174 0.83 9.74 0.47 6.94e-20 Eotaxin levels; LUSC cis rs67981189 0.593 rs221926 chr14:71579135 A/C cg15816911 chr14:71606274 NA -0.34 -5.94 -0.31 7.1e-9 Schizophrenia; LUSC cis rs1949733 0.628 rs1543246 chr4:8504909 A/T cg13073564 chr4:8508604 NA -0.43 -7.95 -0.4 2.93e-14 Response to antineoplastic agents; LUSC cis rs7107174 1.000 rs2292573 chr11:78053139 A/G cg02023728 chr11:77925099 USP35 0.42 6.34 0.33 7.44e-10 Testicular germ cell tumor; LUSC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg01657329 chr11:68192670 LRP5 -0.45 -7.17 -0.37 4.75e-12 Total body bone mineral density; LUSC cis rs4363385 0.747 rs2879488 chr1:152975241 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg07936489 chr17:37558343 FBXL20 -0.67 -9.4 -0.46 9.18e-19 Glomerular filtration rate (creatinine); LUSC cis rs7178375 0.607 rs71474639 chr15:31213257 A/G cg01738805 chr15:31195741 MTMR15 0.87 7.88 0.4 4.64e-14 Hypertriglyceridemia; LUSC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs2296342 0.522 rs1536036 chr6:33632014 A/G cg14003231 chr6:33640908 ITPR3 0.36 7.22 0.37 3.56e-12 Schizophrenia; LUSC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 12.08 0.55 4.15e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9393777 0.623 rs34313099 chr6:26489607 C/T cg12292205 chr6:26970375 C6orf41 -0.64 -7.58 -0.38 3.48e-13 Intelligence (multi-trait analysis); LUSC cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs9865818 0.702 rs6778720 chr3:188118877 G/A cg23651889 chr3:188115336 LPP -0.39 -5.97 -0.31 6.18e-9 Allergic sensitization; LUSC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg02753203 chr1:228287806 NA -0.66 -11.04 -0.52 2.35e-24 Diastolic blood pressure; LUSC trans rs9467711 0.606 rs9379897 chr6:26601526 T/C cg06606381 chr12:133084897 FBRSL1 -0.68 -6.74 -0.35 7.03e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs2243480 1.000 rs464895 chr7:65527106 A/G cg10756647 chr7:56101905 PSPH 0.85 8.14 0.41 7.78e-15 Diabetic kidney disease; LUSC trans rs17301259 0.602 rs1858847 chr7:88336663 T/C cg21771463 chr3:44626400 ZNF660 -0.37 -6.0 -0.31 5.14e-9 Heschl's gyrus morphology; LUSC cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg03264133 chr6:25882463 NA -0.5 -9.15 -0.45 5.97e-18 Blood metabolite levels; LUSC cis rs6547741 0.874 rs28381983 chr2:27804432 T/C cg27432699 chr2:27873401 GPN1 0.81 14.96 0.63 4.41e-39 Oral cavity cancer; LUSC cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg13256891 chr4:100009986 ADH5 0.43 5.97 0.31 5.95e-9 Alcohol dependence; LUSC cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.77 0.47 5.38e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Bladder cancer; LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs56283067 0.847 rs12204270 chr6:44697502 A/T cg18551225 chr6:44695536 NA -0.48 -8.1 -0.41 1.06e-14 Total body bone mineral density; LUSC cis rs7809950 0.953 rs1468336 chr7:107208250 T/C cg23024343 chr7:107201750 COG5 0.55 8.54 0.42 4.66e-16 Coronary artery disease; LUSC cis rs4891159 0.790 rs10514217 chr18:74144939 A/G cg24786174 chr18:74118243 ZNF516 -0.74 -12.96 -0.58 2.21e-31 Longevity; LUSC cis rs477692 1.000 rs531572 chr10:131427569 A/G cg26102564 chr10:131424627 MGMT -0.43 -6.89 -0.35 2.81e-11 Response to temozolomide; LUSC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg06134567 chr22:46658398 PKDREJ -0.46 -5.65 -0.3 3.48e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg25970082 chr1:119683285 WARS2 -0.5 -6.21 -0.32 1.56e-9 Neuroticism; LUSC cis rs12540874 0.542 rs4947581 chr7:50565967 G/A cg18232548 chr7:50535776 DDC -0.59 -9.08 -0.45 9.41e-18 Systemic sclerosis; LUSC cis rs10782582 0.609 rs1796810 chr1:76403305 C/T cg10523679 chr1:76189770 ACADM -0.45 -6.63 -0.34 1.36e-10 Daytime sleep phenotypes; LUSC cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.91 0.4 3.75e-14 Colorectal cancer; LUSC cis rs11098499 1.000 rs3749591 chr4:120214030 T/G cg24375607 chr4:120327624 NA 0.73 10.63 0.5 6.28e-23 Corneal astigmatism; LUSC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg13939156 chr17:80058883 NA -0.33 -6.62 -0.34 1.45e-10 Life satisfaction; LUSC cis rs2404602 0.735 rs4886798 chr15:76673226 A/G cg23625390 chr15:77176239 SCAPER 0.61 9.5 0.46 4.29e-19 Blood metabolite levels; LUSC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg22467129 chr15:76604101 ETFA -0.44 -6.98 -0.36 1.55e-11 Blood metabolite levels; LUSC cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg15103426 chr22:29168792 CCDC117 0.48 5.94 0.31 7.07e-9 Lymphocyte counts; LUSC cis rs10752881 0.967 rs10911186 chr1:182972542 A/G ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.82e-22 Colorectal cancer; LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg01616529 chr11:638424 DRD4 -0.35 -6.02 -0.31 4.64e-9 Systemic lupus erythematosus; LUSC cis rs477692 0.692 rs12265758 chr10:131445144 A/G cg05714579 chr10:131428358 MGMT -0.65 -10.47 -0.5 2.29e-22 Response to temozolomide; LUSC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg22782873 chr19:19639568 YJEFN3 -0.48 -6.1 -0.32 2.86e-9 Bipolar disorder; LUSC cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg05985134 chr18:33552581 C18orf21 0.51 7.01 0.36 1.33e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.77 0.3 1.8e-8 Lung cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14945867 chr14:54908007 CNIH -0.44 -6.47 -0.33 3.51e-10 Electrocardiographic conduction measures; LUSC cis rs1559088 0.600 rs10423965 chr19:33600319 T/G cg03563238 chr19:33554763 RHPN2 -0.37 -6.47 -0.33 3.54e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs478304 0.651 rs948494 chr11:65552118 G/A cg05805236 chr11:65401703 PCNXL3 -0.56 -8.86 -0.44 4.89e-17 Acne (severe); LUSC cis rs559928 0.606 rs7941773 chr11:63952759 C/T cg05555928 chr11:63887634 MACROD1 -0.5 -6.1 -0.32 2.93e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4073582 0.595 rs3016319 chr11:65981846 C/T cg14036092 chr11:66035641 RAB1B 0.43 6.07 0.32 3.47e-9 Gout; LUSC cis rs11112613 0.550 rs73186004 chr12:106043512 A/C cg03607813 chr12:105948248 NA 0.57 7.36 0.37 1.4e-12 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs11098499 0.730 rs78971550 chr4:120281041 C/T cg24375607 chr4:120327624 NA 0.69 10.26 0.49 1.17e-21 Corneal astigmatism; LUSC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg25258033 chr6:167368657 RNASET2 0.48 7.93 0.4 3.43e-14 Crohn's disease; LUSC trans rs877282 0.838 rs11253374 chr10:774961 C/T cg13042288 chr15:90349979 ANPEP -0.48 -6.83 -0.35 3.94e-11 Uric acid levels; LUSC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg00049323 chr5:472564 LOC25845 -0.43 -6.48 -0.33 3.34e-10 Cystic fibrosis severity; LUSC cis rs6906287 0.647 rs6925641 chr6:118821894 C/T cg21191810 chr6:118973309 C6orf204 0.34 6.09 0.32 3.06e-9 Electrocardiographic conduction measures; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11490987 chr7:149535717 ZNF862 -0.48 -6.26 -0.32 1.18e-9 Bipolar disorder and schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18502334 chr7:4681577 NA -0.42 -6.78 -0.35 5.34e-11 Electrocardiographic conduction measures; LUSC cis rs7106204 0.620 rs35008727 chr11:24258035 A/T ch.11.24196551F chr11:24239977 NA 0.73 6.22 0.32 1.49e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg00166722 chr3:10149974 C3orf24 0.61 8.26 0.41 3.47e-15 Alzheimer's disease; LUSC cis rs1865760 0.686 rs12210098 chr6:25963966 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 7.33 0.37 1.8e-12 Height; LUSC cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg03929089 chr4:120376271 NA -1.04 -19.98 -0.74 5.38e-59 Height; LUSC trans rs75804782 0.641 rs72987309 chr2:239348025 A/G cg01134436 chr17:81009848 B3GNTL1 0.63 6.09 0.32 3.04e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs738321 0.757 rs9622732 chr22:38524149 G/C cg25457927 chr22:38595422 NA -0.38 -7.09 -0.36 7.98e-12 Breast cancer; LUSC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.63 0.5 6.47e-23 Menopause (age at onset); LUSC cis rs7945705 0.875 rs10769955 chr11:8784647 G/C cg09997546 chr11:8931473 C11orf17;ST5 0.34 6.76 0.35 6.18e-11 Hemoglobin concentration; LUSC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10207060 0.500 rs56346503 chr2:240719409 T/C cg20333904 chr2:240724165 NA -0.35 -6.11 -0.32 2.84e-9 Obesity-related traits; LUSC cis rs734999 0.545 rs3890745 chr1:2553624 C/T cg18932078 chr1:2524107 MMEL1 -0.32 -7.0 -0.36 1.42e-11 Ulcerative colitis; LUSC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg14416269 chr4:6271139 WFS1 0.54 11.41 0.53 1.08e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11785400 1.000 rs11780221 chr8:143748215 T/A cg10596483 chr8:143751796 JRK 0.6 9.13 0.45 6.74e-18 Schizophrenia; LUSC cis rs7945705 0.869 rs4909952 chr11:8963946 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.64 14.39 0.62 7.53e-37 Hemoglobin concentration; LUSC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg13939156 chr17:80058883 NA 0.34 6.69 0.34 9.61e-11 Life satisfaction; LUSC cis rs68170813 0.652 rs12533694 chr7:107102817 C/T cg02696742 chr7:106810147 HBP1 -0.65 -8.37 -0.42 1.59e-15 Coronary artery disease; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg18765753 chr7:1198926 ZFAND2A -0.53 -9.59 -0.46 2.06e-19 Longevity;Endometriosis; LUSC cis rs9811920 0.809 rs4577503 chr3:99657922 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -7.7 -0.39 1.51e-13 Axial length; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09717979 chr4:103790325 UBE2D3;CISD2 0.45 6.76 0.35 6.1e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg13047869 chr3:10149882 C3orf24 0.63 8.73 0.43 1.21e-16 Alzheimer's disease; LUSC cis rs7394190 0.748 rs3740293 chr10:75406141 A/C cg07699608 chr10:75541558 CHCHD1 0.46 5.8 0.3 1.5e-8 Incident atrial fibrillation; LUSC cis rs4280164 0.943 rs2516564 chr14:24778643 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.62 -7.37 -0.37 1.33e-12 Parent of origin effect on language impairment (paternal); LUSC cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg22862634 chr11:62369728 EML3;MTA2 0.58 9.0 0.44 1.77e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg12292205 chr6:26970375 C6orf41 0.62 10.0 0.48 9.16e-21 Autism spectrum disorder or schizophrenia; LUSC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.37 0.46 1.1e-18 Monocyte percentage of white cells; LUSC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg23711669 chr6:146136114 FBXO30 0.87 15.73 0.65 4.02e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg16447950 chr5:562315 NA -0.57 -6.87 -0.35 3.21e-11 Lung disease severity in cystic fibrosis; LUSC cis rs897984 0.683 rs12926237 chr16:30837596 C/T cg02466173 chr16:30829666 NA 0.68 15.93 0.66 6.81e-43 Dementia with Lewy bodies; LUSC cis rs9467773 1.000 rs6925703 chr6:26521589 G/A cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.11e-18 Intelligence (multi-trait analysis); LUSC cis rs9790314 1.000 rs6775627 chr3:160953609 A/G cg04691961 chr3:161091175 C3orf57 -0.33 -5.7 -0.3 2.65e-8 Morning vs. evening chronotype; LUSC cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg11266682 chr4:10021025 SLC2A9 0.44 8.17 0.41 6.58e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg26384229 chr12:38710491 ALG10B 0.88 15.05 0.64 1.94e-39 Bladder cancer; LUSC trans rs11992162 0.967 rs7836456 chr8:11829175 T/G cg08975724 chr8:8085496 FLJ10661 0.49 7.05 0.36 1.04e-11 Monocyte count; LUSC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11644478 chr21:40555479 PSMG1 0.88 15.18 0.64 5.99e-40 Cognitive function; LUSC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.86 0.4 5.18e-14 Alzheimer's disease; LUSC cis rs6545883 0.929 rs7606167 chr2:61742654 C/G cg15711740 chr2:61764176 XPO1 -0.5 -7.93 -0.4 3.3e-14 Tuberculosis; LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg14895029 chr7:2775587 GNA12 -0.44 -6.65 -0.34 1.19e-10 Height; LUSC cis rs8060686 0.623 rs12599178 chr16:68128104 A/G cg27539214 chr16:67997921 SLC12A4 -0.39 -5.97 -0.31 5.99e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7824557 0.628 rs7820301 chr8:11228672 G/A cg21293242 chr8:11204541 TDH 0.34 6.51 0.34 2.71e-10 Retinal vascular caliber; LUSC cis rs7640424 0.652 rs12152307 chr3:107861766 T/C cg09227934 chr3:107805635 CD47 -0.41 -6.41 -0.33 4.95e-10 Body mass index; LUSC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg21782813 chr7:2030301 MAD1L1 0.48 7.81 0.39 7.37e-14 Schizophrenia; LUSC trans rs7618501 0.574 rs6765484 chr3:50041313 C/T cg21659725 chr3:3221576 CRBN -0.59 -9.76 -0.47 5.59e-20 Intelligence (multi-trait analysis); LUSC cis rs4964805 1.000 rs11111791 chr12:104193271 C/G cg02344784 chr12:104178138 NT5DC3 0.43 6.71 0.34 8.11e-11 Attention deficit hyperactivity disorder; LUSC cis rs2760061 0.819 rs3094914 chr1:228206934 C/T cg01973587 chr1:228161476 NA -0.4 -6.98 -0.36 1.64e-11 Diastolic blood pressure; LUSC cis rs6665290 0.935 rs6670924 chr1:227196048 A/C cg10327440 chr1:227177885 CDC42BPA -1.22 -40.37 -0.91 1.58e-130 Myeloid white cell count; LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg05206690 chr13:30881675 KATNAL1 0.36 6.11 0.32 2.7e-9 Breast cancer; LUSC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg04865166 chr7:105162814 PUS7 0.51 5.71 0.3 2.49e-8 Bipolar disorder (body mass index interaction); LUSC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.81 14.34 0.62 1.11e-36 Total body bone mineral density; LUSC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.17 0.45 4.8e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927592 0.913 rs12284933 chr11:68319489 G/A cg20283391 chr11:68216788 NA -0.61 -8.46 -0.42 8.4e-16 Total body bone mineral density; LUSC cis rs10740039 0.804 rs7902456 chr10:62403695 A/T cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.38e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7917772 0.582 rs4917976 chr10:104360518 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.78 -0.51 1.93e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg05044414 chr3:183734942 ABCC5 0.2 6.8 0.35 4.95e-11 Anterior chamber depth; LUSC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg05347473 chr6:146136440 FBXO30 -0.57 -9.91 -0.48 1.85e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs701145 0.938 rs355749 chr3:153972500 T/C cg17054900 chr3:154042577 DHX36 0.83 8.41 0.42 1.21e-15 Coronary artery disease; LUSC cis rs977987 0.778 rs12930452 chr16:75462055 A/G cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs7267979 1.000 rs7018 chr20:25278261 A/G cg08601574 chr20:25228251 PYGB 0.44 6.69 0.34 9.59e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1371867 0.726 rs1660333 chr8:101309989 A/G cg06636551 chr8:101224915 SPAG1 -0.43 -7.99 -0.4 2.14e-14 Atrioventricular conduction; LUSC trans rs2921073 0.605 rs2976933 chr8:8254875 A/G cg27411982 chr8:10470053 RP1L1 0.4 6.36 0.33 6.76e-10 Parkinson's disease; LUSC cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs2307022 0.586 rs11075672 chr16:68384039 A/G cg02226672 chr16:68398533 SMPD3 0.3 5.78 0.3 1.73e-8 Body mass index; LUSC cis rs7937682 0.575 rs1940391 chr11:111776891 G/A cg22437258 chr11:111473054 SIK2 -0.43 -5.66 -0.3 3.21e-8 Primary sclerosing cholangitis; LUSC cis rs1568889 0.667 rs7123947 chr11:28399908 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.47 6.27 0.32 1.1e-9 Bipolar disorder; LUSC cis rs2456568 0.548 rs1607402 chr11:93660732 T/G cg17595323 chr11:93583763 C11orf90 -0.31 -5.66 -0.3 3.3e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs644799 0.542 rs10831415 chr11:95466159 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.5 6.7 0.34 8.94e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.09 0.52 1.47e-24 Prudent dietary pattern; LUSC cis rs9322817 0.691 rs6922441 chr6:105216405 T/C cg02098413 chr6:105308735 HACE1 -0.28 -5.76 -0.3 1.9e-8 Thyroid stimulating hormone; LUSC cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg23711669 chr6:146136114 FBXO30 0.93 18.64 0.71 1.19e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs1775715 0.678 rs7096139 chr10:32217404 A/C cg18675610 chr10:32216311 ARHGAP12 0.28 6.17 0.32 1.97e-9 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7824557 0.843 rs2572418 chr8:11113089 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -7.33 -0.37 1.78e-12 Retinal vascular caliber; LUSC cis rs17001868 0.568 rs9611314 chr22:40735798 C/G cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs7100689 0.622 rs1340379 chr10:82121455 G/A cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs4692589 0.802 rs2877501 chr4:170955277 G/T cg19918862 chr4:170955249 NA 0.32 6.24 0.32 1.33e-9 Anxiety disorder; LUSC cis rs10207060 0.500 rs62183161 chr2:240699856 C/T cg20333904 chr2:240724165 NA -0.38 -6.33 -0.33 7.69e-10 Obesity-related traits; LUSC cis rs3849570 0.925 rs6765917 chr3:81891116 C/T cg07356753 chr3:81810745 GBE1 -0.67 -10.95 -0.51 4.77e-24 Waist circumference;Body mass index; LUSC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg18904891 chr8:8559673 CLDN23 0.59 8.1 0.41 1.03e-14 Obesity-related traits; LUSC trans rs2243480 1.000 rs4718270 chr7:65202407 A/G cg10756647 chr7:56101905 PSPH 0.84 8.31 0.41 2.46e-15 Diabetic kidney disease; LUSC trans rs8002861 0.905 rs12428350 chr13:44446161 G/A cg12856521 chr11:46389249 DGKZ -0.4 -6.38 -0.33 5.78e-10 Leprosy; LUSC cis rs6582630 0.539 rs4882324 chr12:38499180 T/C cg26384229 chr12:38710491 ALG10B -0.57 -8.66 -0.43 2.04e-16 Drug-induced liver injury (flucloxacillin); LUSC trans rs656319 0.513 rs17746227 chr8:9981654 T/C cg06636001 chr8:8085503 FLJ10661 -0.46 -6.43 -0.33 4.44e-10 Myopia (pathological); LUSC cis rs877282 0.945 rs11253397 chr10:789774 A/G cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs6142102 0.602 rs2268086 chr20:32648738 C/T cg24642439 chr20:33292090 TP53INP2 -0.39 -5.66 -0.3 3.24e-8 Skin pigmentation; LUSC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg16325326 chr1:53192061 ZYG11B 0.9 17.08 0.68 1.86e-47 Monocyte count; LUSC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs7590255 0.876 rs4629139 chr2:37985487 A/G cg23497611 chr2:37985316 NA -0.41 -6.26 -0.32 1.18e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs6429082 0.634 rs3856245 chr1:235571428 G/A cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.82 -0.35 4.3e-11 Adiposity; LUSC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.84 0.75 2.15e-62 Homoarginine levels; LUSC cis rs1728785 0.901 rs1170420 chr16:68635877 G/C cg02972257 chr16:68554789 NA -0.5 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC cis rs12210905 0.841 rs72839470 chr6:27309304 T/A cg11502198 chr6:26597334 ABT1 -0.83 -5.72 -0.3 2.39e-8 Hip circumference adjusted for BMI; LUSC cis rs72781680 1.000 rs72796388 chr2:24171509 A/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs9395066 0.545 rs3799977 chr6:44837356 G/T cg25276700 chr6:44698697 NA -0.3 -6.12 -0.32 2.58e-9 Height; LUSC cis rs9814567 1.000 rs4367113 chr3:134287975 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.01 -0.61 2.13e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -8.62 -0.43 2.71e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23194354 chr7:3340459 SDK1 -0.46 -6.06 -0.31 3.77e-9 Bipolar disorder and schizophrenia; LUSC cis rs7267979 0.844 rs6107017 chr20:25232300 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.68 12.94 0.58 2.53e-31 Liver enzyme levels (alkaline phosphatase); LUSC cis rs617219 0.819 rs72764990 chr5:78536190 C/G cg24856658 chr5:78533917 JMY -0.29 -5.79 -0.3 1.65e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg18357645 chr12:58087776 OS9 -0.5 -6.67 -0.34 1.03e-10 Multiple sclerosis; LUSC cis rs6736093 0.799 rs13025651 chr2:112777853 A/G cg12686935 chr2:112915763 FBLN7 -0.4 -6.29 -0.33 1.01e-9 Coronary artery disease; LUSC trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.17 -0.32 1.98e-9 Triglycerides; LUSC cis rs7945718 0.967 rs11022491 chr11:12777620 A/G cg25843174 chr11:12811716 TEAD1 -0.3 -6.87 -0.35 3.2e-11 Educational attainment (years of education); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13319488 chr13:44361064 ENOX1 -0.55 -6.52 -0.34 2.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs3008870 0.755 rs2815360 chr1:67494458 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.43 0.56 1.97e-29 Lymphocyte percentage of white cells; LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg21782813 chr7:2030301 MAD1L1 0.53 9.42 0.46 7.44e-19 Bipolar disorder and schizophrenia; LUSC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg03929089 chr4:120376271 NA -0.78 -12.29 -0.56 6.65e-29 Height; LUSC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg11245181 chr6:149772854 ZC3H12D 0.29 6.3 0.33 9.28e-10 Dupuytren's disease; LUSC cis rs858239 0.601 rs4599714 chr7:23168801 C/T cg23682824 chr7:23144976 KLHL7 0.41 5.94 0.31 7.13e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs2115630 1.000 rs6496441 chr15:85363348 A/G cg09876464 chr15:85330779 ZNF592 0.36 6.69 0.34 9.21e-11 P wave terminal force; LUSC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg00343986 chr7:65444356 GUSB 0.43 6.65 0.34 1.21e-10 Aortic root size; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03024714 chr1:29557626 MECR -0.47 -6.11 -0.32 2.71e-9 Hepatitis; LUSC cis rs4319547 0.656 rs10773088 chr12:122828069 A/T cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.28 -0.41 3.06e-15 Body mass index; LUSC cis rs7223966 0.921 rs2727300 chr17:61965398 G/A cg00945038 chr17:61921165 SMARCD2 0.37 5.64 0.3 3.58e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs908922 0.676 rs4845441 chr1:152485421 C/T cg20991723 chr1:152506922 NA 0.52 9.7 0.47 8.97e-20 Hair morphology; LUSC cis rs4919694 1.000 rs11191490 chr10:104745174 T/A cg23093090 chr10:104574429 C10orf26 -0.5 -5.91 -0.31 8.52e-9 Arsenic metabolism; LUSC cis rs2637266 0.627 rs1992396 chr10:78482228 T/C cg18941641 chr10:78392320 NA 0.33 6.02 0.31 4.51e-9 Pulmonary function; LUSC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC cis rs4555082 1.000 rs4555082 chr14:105758964 C/T cg13114125 chr14:105738426 BRF1 -0.86 -14.21 -0.61 3.63e-36 Mean platelet volume;Platelet distribution width; LUSC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg06637938 chr14:75390232 RPS6KL1 0.85 15.8 0.65 2.12e-42 Caffeine consumption; LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg13560548 chr3:10150139 C3orf24 0.48 6.6 0.34 1.6e-10 Alzheimer's disease; LUSC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.24e-10 Aortic root size; LUSC cis rs7107174 1.000 rs2512538 chr11:77972461 T/G cg02023728 chr11:77925099 USP35 0.52 7.2 0.37 4.11e-12 Testicular germ cell tumor; LUSC trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg03929089 chr4:120376271 NA -0.54 -6.71 -0.34 8.48e-11 Acute lymphoblastic leukemia (childhood); LUSC trans rs1941687 1.000 rs1941687 chr18:31334667 A/C cg27147174 chr7:100797783 AP1S1 -0.44 -6.53 -0.34 2.49e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs4363385 0.747 rs4568784 chr1:152972694 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.88 -0.4 4.72e-14 Inflammatory skin disease; LUSC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg03526776 chr6:41159608 TREML2 0.33 6.25 0.32 1.26e-9 Alzheimer's disease (late onset); LUSC cis rs61931739 0.500 rs6488213 chr12:34393319 C/T cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC cis rs9361491 0.621 rs12196457 chr6:79627743 A/T cg23262351 chr6:79576851 IRAK1BP1 -0.39 -5.92 -0.31 7.88e-9 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg04267008 chr7:1944627 MAD1L1 -0.52 -7.88 -0.4 4.78e-14 Bipolar disorder and schizophrenia; LUSC cis rs870825 0.616 rs7678864 chr4:185635158 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.19 0.59 2.82e-32 Blood protein levels; LUSC cis rs35771425 0.626 rs6677230 chr1:211652902 A/C cg10512769 chr1:211675356 NA -0.27 -6.07 -0.32 3.5e-9 Educational attainment (years of education); LUSC cis rs1003719 0.553 rs1063948 chr21:38574674 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.19 -0.49 2e-21 Eye color traits; LUSC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg27535305 chr1:53392650 SCP2 0.33 5.97 0.31 6e-9 Monocyte count; LUSC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg03806693 chr22:41940476 POLR3H -1.03 -13.9 -0.61 5.73e-35 Vitiligo; LUSC cis rs2970818 0.831 rs2907499 chr12:4616901 G/T cg11146114 chr12:4671731 NA 0.58 6.12 0.32 2.61e-9 Phosphorus levels; LUSC cis rs476633 0.691 rs6492997 chr15:41541171 G/A cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.34 -0.42 1.91e-15 Glomerular filtration rate (creatinine); LUSC cis rs793571 0.614 rs347117 chr15:59000957 C/T cg05156742 chr15:59063176 FAM63B 0.52 7.63 0.39 2.44e-13 Schizophrenia; LUSC cis rs10876993 0.826 rs1678534 chr12:58057435 A/C cg15848620 chr12:58087721 OS9 -0.53 -7.69 -0.39 1.68e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg17948913 chr5:572064 NA 0.38 6.27 0.32 1.09e-9 Obesity-related traits; LUSC cis rs244731 1.000 rs244731 chr5:176539679 C/T cg16006841 chr5:176797999 RGS14 0.68 8.72 0.43 1.35e-16 Urate levels in lean individuals; LUSC cis rs7666738 0.716 rs6827474 chr4:99089683 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.76 0.47 5.95e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.8 -0.35 4.9e-11 Lung cancer; LUSC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC trans rs10435719 0.902 rs7459545 chr8:11804389 G/T cg27411982 chr8:10470053 RP1L1 0.4 6.24 0.32 1.29e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1163251 0.837 rs2764886 chr1:120241771 C/T cg19096424 chr1:120255104 PHGDH 0.45 6.11 0.32 2.76e-9 Blood metabolite levels; LUSC cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.15 -0.36 5.36e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC trans rs1922233 0.943 rs1922228 chr4:92380200 A/G cg24250684 chr1:219729030 NA -0.32 -5.99 -0.31 5.54e-9 Gut microbiome composition (summer and winter); LUSC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg04248312 chr19:17393744 ANKLE1 -0.99 -16.66 -0.67 9.09e-46 Systemic lupus erythematosus; LUSC trans rs3198697 1.000 rs3198697 chr16:15129940 C/T cg27517281 chr16:2148693 PKD1 -0.31 -6.18 -0.32 1.9e-9 Triglycerides; LUSC cis rs6591182 0.504 rs7130955 chr11:65372580 C/T cg27068330 chr11:65405492 SIPA1 -0.66 -9.42 -0.46 7.5e-19 Non-alcoholic fatty liver disease histology (lobular); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14825729 chr4:147866863 TTC29 -0.52 -7.11 -0.36 6.94e-12 Bipolar disorder and schizophrenia; LUSC cis rs908922 0.676 rs568661 chr1:152519787 C/A cg20991723 chr1:152506922 NA 0.5 9.28 0.45 2.18e-18 Hair morphology; LUSC cis rs6005807 0.719 rs2881496 chr22:28921265 C/G cg12565055 chr22:29076175 TTC28 -0.54 -5.79 -0.3 1.6e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC trans rs1422110 0.681 rs35625401 chr5:85465408 G/A cg01787110 chr1:109008453 NBPF6 0.54 8.87 0.44 4.37e-17 Attention function in attention deficit hyperactive disorder; LUSC cis rs10992471 0.603 rs11794346 chr9:95247288 C/T cg14631576 chr9:95140430 CENPP -0.33 -6.05 -0.31 3.83e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg26441486 chr22:50317300 CRELD2 -0.54 -8.25 -0.41 3.75e-15 Schizophrenia; LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg10802521 chr3:52805072 NEK4 -0.55 -8.79 -0.43 8.19e-17 Bipolar disorder; LUSC cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg23029597 chr12:123009494 RSRC2 -0.7 -9.69 -0.47 9.71e-20 Body mass index; LUSC trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg15556689 chr8:8085844 FLJ10661 -0.64 -10.38 -0.49 4.53e-22 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg12365402 chr11:9010492 NRIP3 0.37 6.35 0.33 6.85e-10 Hemoglobin concentration; LUSC cis rs1847202 0.859 rs4550778 chr3:72949198 G/A cg25664220 chr3:72788482 NA -0.41 -7.36 -0.37 1.44e-12 Motion sickness; LUSC cis rs9902453 0.845 rs7218113 chr17:28372130 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.48 -0.5 2.04e-22 Coffee consumption (cups per day); LUSC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg06636001 chr8:8085503 FLJ10661 0.59 9.14 0.45 6.38e-18 Mood instability; LUSC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg17366294 chr4:99064904 C4orf37 0.56 8.2 0.41 5.13e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.898 rs72796158 chr2:23935727 T/C cg20701182 chr2:24300061 SF3B14 0.74 7.28 0.37 2.48e-12 Lymphocyte counts; LUSC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.06 -0.48 5.7e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1696756 0.638 rs1285274 chr17:77829907 G/A cg00646381 chr17:77835854 NA 0.59 9.34 0.46 1.36e-18 Glucocorticoid-induced osteonecrosis (age 10 years and older); LUSC cis rs8113142 0.651 rs8104685 chr19:29058834 A/G cg04546413 chr19:29218101 NA 0.46 6.02 0.31 4.7e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg16743903 chr16:89593216 SPG7 -0.39 -6.18 -0.32 1.83e-9 Multiple myeloma (IgH translocation); LUSC trans rs7552393 0.636 rs12135529 chr1:84293113 C/T cg23537141 chr10:80875585 ZMIZ1 -0.36 -6.02 -0.31 4.64e-9 Select biomarker traits; LUSC cis rs7615952 0.515 rs4441610 chr3:125681307 C/G cg02807482 chr3:125708958 NA -0.43 -5.65 -0.3 3.41e-8 Blood pressure (smoking interaction); LUSC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg21138405 chr5:131827807 IRF1 -0.56 -10.84 -0.51 1.18e-23 Asthma (sex interaction); LUSC cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs4499344 0.805 rs116855540 chr19:33083830 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.59 -7.75 -0.39 1.13e-13 Mean platelet volume; LUSC cis rs2073300 0.609 rs2277765 chr20:23425163 C/T cg12062639 chr20:23401060 NAPB 0.98 8.38 0.42 1.5e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs708547 0.836 rs1612191 chr4:57724320 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.57 -7.14 -0.36 5.92e-12 Response to bleomycin (chromatid breaks); LUSC cis rs7705502 1.000 rs17696147 chr5:173373143 T/C cg18693985 chr5:173351052 CPEB4 -0.37 -5.83 -0.3 1.3e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7760535 0.826 rs3851229 chr6:111854660 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.38 -7.1 -0.36 7.54e-12 Metabolic traits; LUSC cis rs9341808 0.667 rs3805919 chr6:80906809 C/G cg08355045 chr6:80787529 NA 0.46 7.96 0.4 2.75e-14 Sitting height ratio; LUSC cis rs5758659 1.000 rs5758659 chr22:42622003 C/T cg04733989 chr22:42467013 NAGA 0.39 6.07 0.32 3.39e-9 Cognitive function; LUSC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg00024416 chr22:24240387 NA -0.47 -7.59 -0.38 3.27e-13 Urinary 1,3-butadiene metabolite levels in smokers; LUSC trans rs7824557 0.603 rs2250028 chr8:11213589 T/G cg06636001 chr8:8085503 FLJ10661 0.58 8.39 0.42 1.4e-15 Retinal vascular caliber; LUSC cis rs7727544 0.547 rs10076758 chr5:131524299 A/G cg14196790 chr5:131705035 SLC22A5 0.46 7.64 0.39 2.29e-13 Blood metabolite levels; LUSC trans rs61931739 0.629 rs708146 chr12:33731808 C/G cg26384229 chr12:38710491 ALG10B 0.43 6.18 0.32 1.9e-9 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10699881 chr4:6271512 WFS1 -0.42 -6.41 -0.33 4.85e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17345786 1.000 rs55641278 chr3:101290577 G/A cg12386194 chr3:101231763 SENP7 0.54 7.08 0.36 8.81e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7582720 0.943 rs72934546 chr2:203980033 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.7 0.43 1.56e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs9693857 0.501 rs67985496 chr8:9263128 T/C cg15556689 chr8:8085844 FLJ10661 -0.46 -6.06 -0.31 3.63e-9 Systolic blood pressure; LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg08888203 chr3:10149979 C3orf24 0.58 7.61 0.38 2.91e-13 Alzheimer's disease; LUSC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg07701084 chr6:150067640 NUP43 0.55 8.41 0.42 1.21e-15 Lung cancer; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg22090150 chr17:4098227 ANKFY1 -0.37 -5.94 -0.31 7.03e-9 N-glycan levels; LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 7.17 0.37 4.8e-12 Platelet count; LUSC cis rs9325144 0.560 rs7980358 chr12:38640396 C/G cg26384229 chr12:38710491 ALG10B 0.67 10.13 0.48 3.23e-21 Morning vs. evening chronotype; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20061884 chr7:108210449 THAP5;DNAJB9 -0.4 -6.09 -0.32 3.07e-9 Electrocardiographic conduction measures; LUSC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21582582 chr3:182698605 DCUN1D1 -0.46 -8.23 -0.41 4.21e-15 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg02475777 chr4:1388615 CRIPAK 0.45 6.65 0.34 1.2e-10 Obesity-related traits; LUSC trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg15556689 chr8:8085844 FLJ10661 0.58 9.06 0.44 1.08e-17 Retinal vascular caliber; LUSC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.23 0.32 1.43e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11711311 1.000 rs9855613 chr3:113448455 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.51 6.93 0.35 2.22e-11 IgG glycosylation; LUSC cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.13 0.45 6.5e-18 Motion sickness; LUSC cis rs9325144 0.600 rs12424410 chr12:38758035 A/T cg13010199 chr12:38710504 ALG10B -0.49 -7.47 -0.38 7.08e-13 Morning vs. evening chronotype; LUSC cis rs7917772 0.512 rs11594073 chr10:104308193 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.67 -10.93 -0.51 5.48e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg06873352 chr17:61820015 STRADA 0.7 12.7 0.57 1.95e-30 Prudent dietary pattern; LUSC cis rs7804356 0.953 rs12534921 chr7:26877210 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.12 -0.32 2.58e-9 Type 1 diabetes; LUSC cis rs3540 0.597 rs3743409 chr15:91045539 T/A cg22089800 chr15:90895588 ZNF774 -0.64 -9.65 -0.47 1.3e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs11098499 0.954 rs3733520 chr4:120423480 C/G cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.03e-14 Corneal astigmatism; LUSC cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg25427524 chr10:38739819 LOC399744 0.45 7.41 0.38 1.07e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg22508957 chr16:3507546 NAT15 -0.4 -5.84 -0.3 1.22e-8 Body mass index (adult); LUSC cis rs7917772 0.582 rs10748826 chr10:104354804 T/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.42 -0.38 9.5e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2806561 0.808 rs1413974 chr1:23347125 C/T cg19743168 chr1:23544995 NA -0.44 -9.11 -0.45 7.89e-18 Height; LUSC cis rs6594499 0.500 rs12514810 chr5:110455357 T/A cg04022379 chr5:110408740 TSLP 0.6 9.15 0.45 5.73e-18 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg27170947 chr2:26402098 FAM59B -0.63 -9.02 -0.44 1.55e-17 Gut microbiome composition (summer); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg00661222 chr13:52343378 DHRS12 -0.37 -6.04 -0.31 4.06e-9 N-glycan levels; LUSC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.52 9.43 0.46 7.19e-19 Bipolar disorder; LUSC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg08859206 chr1:53392774 SCP2 0.5 8.57 0.42 4e-16 Monocyte count; LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.89 -12.68 -0.57 2.34e-30 Platelet count; LUSC trans rs7726839 0.526 rs11960159 chr5:568685 C/T cg11887960 chr12:57824829 NA 0.46 6.47 0.33 3.41e-10 Obesity-related traits; LUSC trans rs6981523 0.500 rs4412337 chr8:11072020 C/T cg08975724 chr8:8085496 FLJ10661 0.43 5.96 0.31 6.55e-9 Neuroticism; LUSC cis rs7523273 0.586 rs2796264 chr1:207919968 A/G cg22525895 chr1:207977042 MIR29B2 0.4 6.62 0.34 1.42e-10 Schizophrenia; LUSC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg10556349 chr10:835070 NA 0.54 6.11 0.32 2.81e-9 Eosinophil percentage of granulocytes; LUSC cis rs10392 0.543 rs62204117 chr20:37565335 T/C cg27552599 chr20:37590471 DHX35 0.43 7.11 0.36 7e-12 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC trans rs11098499 0.779 rs7674500 chr4:120303593 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.39 5.78 0.3 1.72e-8 Schizophrenia; LUSC trans rs11039798 1.000 rs7104642 chr11:48588534 C/T cg03929089 chr4:120376271 NA 0.66 6.16 0.32 2.03e-9 Axial length; LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7336332 0.598 rs1885989 chr13:28010117 G/A cg22138327 chr13:27999177 GTF3A 0.8 9.68 0.47 1.1e-19 Weight; LUSC trans rs62103177 0.608 rs34383580 chr18:77833263 A/G cg14227996 chr4:17616232 MED28 -0.54 -6.01 -0.31 4.92e-9 Opioid sensitivity; LUSC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg15839431 chr19:19639596 YJEFN3 -0.41 -5.78 -0.3 1.75e-8 Tonsillectomy; LUSC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg22800045 chr5:56110881 MAP3K1 -0.42 -5.74 -0.3 2.17e-8 Coronary artery disease; LUSC cis rs11122272 0.735 rs2024878 chr1:231528415 A/C cg06096015 chr1:231504339 EGLN1 -0.55 -9.81 -0.47 3.99e-20 Hemoglobin concentration; LUSC cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.52 -7.82 -0.39 6.9e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg13319975 chr6:146136371 FBXO30 0.46 7.09 0.36 7.87e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs709400 0.628 rs11622356 chr14:103912195 C/T cg12935359 chr14:103987150 CKB -0.56 -8.48 -0.42 7.62e-16 Body mass index; LUSC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg19468946 chr17:37922297 IKZF3 -0.39 -6.33 -0.33 7.85e-10 Self-reported allergy; LUSC cis rs7584330 0.737 rs60187585 chr2:238365159 C/T cg16989719 chr2:238392110 NA -0.41 -7.25 -0.37 3e-12 Prostate cancer; LUSC cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg17063962 chr7:91808500 NA 0.61 9.8 0.47 4.17e-20 Breast cancer; LUSC cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg05347473 chr6:146136440 FBXO30 0.46 7.77 0.39 9.95e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs36093844 1.000 rs11234452 chr11:85576801 C/T cg16165120 chr11:85566439 CCDC83 -0.35 -5.8 -0.3 1.54e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs10752881 1.000 rs12133714 chr1:182988252 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.87e-23 Colorectal cancer; LUSC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg03934478 chr11:495069 RNH1 0.89 10.11 0.48 3.79e-21 Body mass index; LUSC cis rs34375054 0.672 rs10400509 chr12:125592173 T/C cg06287003 chr12:125626642 AACS -0.39 -6.85 -0.35 3.55e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.09e-11 Blood metabolite levels; LUSC cis rs1691799 0.867 rs1168332 chr12:66761548 C/T cg16791601 chr12:66731901 HELB -0.68 -12.14 -0.55 2.53e-28 White blood cell count (basophil); LUSC cis rs782590 0.902 rs2586947 chr2:55854009 C/G cg03859395 chr2:55845619 SMEK2 0.83 15.2 0.64 5.18e-40 Metabolic syndrome; LUSC cis rs782590 0.967 rs62165173 chr2:55741666 T/C cg18811423 chr2:55921094 PNPT1 0.83 14.37 0.62 8.87e-37 Metabolic syndrome; LUSC cis rs8062405 1.000 rs12446589 chr16:28870962 G/A cg09754948 chr16:28834200 ATXN2L 0.41 5.84 0.3 1.24e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Tonsillectomy; LUSC cis rs6582630 0.555 rs11180986 chr12:38264486 G/A cg13010199 chr12:38710504 ALG10B -0.47 -7.04 -0.36 1.07e-11 Drug-induced liver injury (flucloxacillin); LUSC trans rs11613704 1 rs11613704 chr12:980925 C/A cg27417659 chr7:98567827 TRRAP -0.5 -6.08 -0.32 3.21e-9 Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg11764359 chr7:65958608 NA 0.62 9.34 0.46 1.4e-18 Aortic root size; LUSC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg09455208 chr3:40491958 NA 0.6 10.67 0.5 4.72e-23 Renal cell carcinoma; LUSC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg11645453 chr3:52864694 ITIH4 0.38 8.65 0.43 2.25e-16 Bipolar disorder; LUSC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.57 -7.02 -0.36 1.27e-11 Lung function (FEV1/FVC); LUSC trans rs2898290 0.540 rs12677146 chr8:11450737 C/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.2 -0.32 1.69e-9 Systolic blood pressure; LUSC cis rs763014 1.000 rs763014 chr16:675680 T/C cg03804128 chr16:635623 NA 0.31 6.16 0.32 2.1e-9 Height; LUSC cis rs8072100 0.967 rs9894905 chr17:45485982 C/T cg25173405 chr17:45401733 C17orf57 -0.4 -6.47 -0.33 3.57e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -14.87 -0.63 9.93e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 0.941 rs7257875 chr19:19372150 C/T cg11244672 chr19:19639970 YJEFN3 -0.52 -6.49 -0.33 3.05e-10 Bipolar disorder; LUSC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg16797656 chr11:68205561 LRP5 0.38 6.87 0.35 3.14e-11 Total body bone mineral density; LUSC cis rs2857891 0.695 rs2857895 chr11:6982992 C/G cg04053776 chr11:6947353 ZNF215 -0.4 -6.1 -0.32 2.95e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs17125944 0.505 rs10483617 chr14:53202605 A/G cg00686598 chr14:53173677 PSMC6 -1.2 -11.16 -0.52 8.34e-25 Alzheimer's disease (late onset); LUSC cis rs7481584 0.624 rs397919 chr11:3063094 A/C cg05729581 chr11:3078854 CARS 0.41 6.08 0.32 3.36e-9 Calcium levels; LUSC trans rs1910358 0.554 rs10057796 chr5:23759746 C/T cg18225582 chr14:65171304 PLEKHG3 0.41 6.13 0.32 2.5e-9 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs7819412 0.740 rs7844536 chr8:11034028 A/G cg21775007 chr8:11205619 TDH -0.5 -7.05 -0.36 1.01e-11 Triglycerides; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.2e-26 Prudent dietary pattern; LUSC cis rs11098499 0.722 rs17595727 chr4:120262074 C/T cg24375607 chr4:120327624 NA -0.7 -11.03 -0.52 2.45e-24 Corneal astigmatism; LUSC cis rs9467711 0.720 rs1417998 chr6:26162019 T/A cg16898833 chr6:26189333 HIST1H4D 0.71 6.88 0.35 3.05e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs35000415 0.938 rs12531711 chr7:128617466 A/G cg19972273 chr7:128594194 NA 0.64 6.68 0.34 9.76e-11 Systemic lupus erythematosus; LUSC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg11871910 chr12:69753446 YEATS4 -0.91 -17.32 -0.69 2.16e-48 Cerebrospinal fluid biomarker levels; LUSC cis rs68170813 0.559 rs10487271 chr7:106898458 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.87e-20 Coronary artery disease; LUSC cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg12011299 chr4:100065546 ADH4 -0.7 -10.7 -0.51 3.54e-23 Alcohol dependence; LUSC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg05425664 chr17:57184151 TRIM37 0.54 8.01 0.4 1.91e-14 Intelligence (multi-trait analysis); LUSC cis rs894734 0.535 rs2366142 chr12:54323148 T/C cg17410650 chr12:54324560 NA -0.57 -10.35 -0.49 5.7e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs17739794 0.517 rs6982473 chr8:773986 G/T cg07178994 chr8:816998 NA -0.39 -5.78 -0.3 1.74e-8 Clozapine-induced cytotoxicity; LUSC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg05132306 chr1:1846340 CALML6 0.24 5.95 0.31 6.74e-9 Body mass index; LUSC cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg16989719 chr2:238392110 NA -0.44 -7.45 -0.38 7.93e-13 Prostate cancer; LUSC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg08859206 chr1:53392774 SCP2 0.47 7.88 0.4 4.71e-14 Monocyte count; LUSC cis rs6977940 0.558 rs117222922 chr7:2891608 G/A cg19731401 chr7:2775893 GNA12 0.69 7.54 0.38 4.62e-13 White matter integrity; LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4319547 0.695 rs12314643 chr12:122917423 C/T cg23029597 chr12:123009494 RSRC2 -0.64 -8.27 -0.41 3.19e-15 Body mass index; LUSC cis rs868036 0.645 rs28539889 chr15:68121428 T/A cg05925327 chr15:68127851 NA -0.47 -6.88 -0.35 3e-11 Restless legs syndrome; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg21200380 chr17:5342446 C1QBP -0.44 -5.98 -0.31 5.83e-9 Hepatitis; LUSC cis rs11785400 0.793 rs4457308 chr8:143733922 G/A cg24634471 chr8:143751801 JRK 0.51 7.27 0.37 2.6e-12 Schizophrenia; LUSC cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.44 6.62 0.34 1.47e-10 Systemic lupus erythematosus; LUSC trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg15704280 chr7:45808275 SEPT13 0.67 7.37 0.37 1.35e-12 Axial length; LUSC cis rs1595825 0.945 rs73056890 chr2:198831260 A/G cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 6.08e-9 Ulcerative colitis; LUSC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg20701182 chr2:24300061 SF3B14 0.9 11.58 0.54 2.61e-26 Lymphocyte counts; LUSC cis rs7584330 0.697 rs60278044 chr2:238357118 A/G cg16989719 chr2:238392110 NA -0.35 -5.84 -0.3 1.22e-8 Prostate cancer; LUSC cis rs1505368 0.505 rs1394781 chr2:213248822 C/T cg16329650 chr2:213403929 ERBB4 -0.49 -7.97 -0.4 2.61e-14 Symmetrical dimethylarginine levels; LUSC cis rs17401966 1.000 rs58549151 chr1:10314657 A/C cg19773385 chr1:10388646 KIF1B -0.53 -8.3 -0.41 2.57e-15 Hepatocellular carcinoma; LUSC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg25174290 chr11:3078921 CARS 0.57 8.76 0.43 1.03e-16 Longevity; LUSC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.65 0.3 3.51e-8 Self-reported allergy; LUSC cis rs6084875 0.840 rs743252 chr20:4720667 C/T cg07258627 chr20:4721683 PRNT -0.34 -6.2 -0.32 1.69e-9 Systemic lupus erythematosus; LUSC cis rs2933343 0.700 rs1683779 chr3:128642048 A/G cg11901034 chr3:128598214 ACAD9 -0.41 -6.46 -0.33 3.62e-10 IgG glycosylation; LUSC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.3 5.74 0.3 2.18e-8 Schizophrenia; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.78 -0.35 5.44e-11 Menopause (age at onset); LUSC cis rs394563 0.726 rs366905 chr6:149735097 T/A cg07828024 chr6:149772892 ZC3H12D -0.34 -7.38 -0.37 1.23e-12 Dupuytren's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22435081 chr17:41323035 NBR1 0.45 6.0 0.31 5.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.51e-15 Axial length; LUSC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.73e-23 Bladder cancer; LUSC trans rs1325195 0.879 rs10913695 chr1:179083469 T/G cg11624085 chr17:8464688 MYH10 -0.45 -7.36 -0.37 1.49e-12 IgE grass sensitization; LUSC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg23985595 chr17:80112537 CCDC57 0.31 5.88 0.31 9.8e-9 Life satisfaction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14737296 chr12:133212394 POLE -0.48 -7.56 -0.38 3.82e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4722166 0.508 rs2069832 chr7:22767433 A/G cg05472934 chr7:22766657 IL6 0.53 8.28 0.41 2.91e-15 Lung cancer; LUSC cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg08999081 chr20:33150536 PIGU -0.54 -10.77 -0.51 2.06e-23 Glomerular filtration rate (creatinine); LUSC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg06108461 chr20:60628389 TAF4 -0.96 -16.54 -0.67 2.55e-45 Body mass index; LUSC cis rs9911578 0.813 rs8066773 chr17:56601552 A/G cg05425664 chr17:57184151 TRIM37 -0.55 -8.01 -0.4 1.94e-14 Intelligence (multi-trait analysis); LUSC cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg06784218 chr1:46089804 CCDC17 0.34 5.69 0.3 2.77e-8 Platelet count; LUSC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.86 0.35 3.37e-11 Intelligence (multi-trait analysis); LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg24060327 chr5:131705240 SLC22A5 -0.53 -8.78 -0.43 8.48e-17 Acylcarnitine levels; LUSC cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.42e-16 Menopause (age at onset); LUSC cis rs9302690 0.557 rs223869 chr16:57494992 C/A cg27017172 chr16:57497170 POLR2C 0.67 5.99 0.31 5.41e-9 Blood protein levels; LUSC cis rs8077889 0.871 rs16940243 chr17:41900003 C/G cg26893861 chr17:41843967 DUSP3 0.88 13.8 0.6 1.38e-34 Triglycerides; LUSC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -8.4 -0.42 1.29e-15 Alzheimer's disease; LUSC cis rs148387471 1 rs148387471 chr3:127057551 ATAG/A cg21487550 chr3:127056955 NA -0.47 -6.53 -0.34 2.41e-10 Interleukin-10 levels;Interleukin-13 levels; LUSC cis rs77106637 1.000 rs11600585 chr11:72727840 A/G cg04827223 chr11:72435913 ARAP1 -0.65 -8.26 -0.41 3.37e-15 Type 2 diabetes; LUSC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.47 6.9 0.35 2.56e-11 Schizophrenia; LUSC cis rs2760061 0.583 rs1636195 chr1:228211589 T/C cg04850211 chr1:228464232 OBSCN -0.37 -6.24 -0.32 1.35e-9 Diastolic blood pressure; LUSC cis rs11122272 0.705 rs2491411 chr1:231533448 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.11 -0.48 3.98e-21 Hemoglobin concentration; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.62 0.39 2.57e-13 Calcium levels; LUSC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.78 0.47 4.89e-20 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg07507251 chr3:52567010 NT5DC2 0.32 6.25 0.32 1.28e-9 Bipolar disorder; LUSC cis rs425277 0.916 rs414777 chr1:2101687 G/A cg03732007 chr1:2071316 PRKCZ 0.47 7.61 0.38 2.8e-13 Height; LUSC cis rs12973672 1.000 rs1052033 chr19:35770471 C/T cg12095397 chr19:35769544 USF2 0.44 6.91 0.35 2.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs394563 0.601 rs376269 chr6:149795154 C/T cg07828024 chr6:149772892 ZC3H12D -0.38 -7.85 -0.39 5.65e-14 Dupuytren's disease; LUSC cis rs1775715 1.000 rs1251363 chr10:32328526 G/C cg26784012 chr10:32216390 ARHGAP12 -0.39 -6.19 -0.32 1.74e-9 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23628684 chr21:30446052 CCT8 0.44 6.17 0.32 1.96e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg06808227 chr14:105710500 BRF1 -0.72 -11.64 -0.54 1.66e-26 Mean platelet volume;Platelet distribution width; LUSC cis rs6736093 0.862 rs79798002 chr2:112733978 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.96 -0.31 6.32e-9 Coronary artery disease; LUSC cis rs2658782 0.738 rs2605628 chr11:93261560 C/A cg15737290 chr11:93063684 CCDC67 0.62 7.6 0.38 3.02e-13 Pulmonary function decline; LUSC trans rs3733585 0.673 rs4627861 chr4:9954238 T/G cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg24060327 chr5:131705240 SLC22A5 -0.36 -5.98 -0.31 5.89e-9 Blood metabolite levels; LUSC cis rs7617480 0.648 rs6766238 chr3:48801929 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.66 10.0 0.48 9.39e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.39 -0.37 1.2e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6142102 0.961 rs4911393 chr20:32570926 A/G cg08999081 chr20:33150536 PIGU 0.34 5.9 0.31 9.15e-9 Skin pigmentation; LUSC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg00800038 chr16:89945340 TCF25 -0.75 -6.58 -0.34 1.83e-10 Skin colour saturation; LUSC cis rs981844 1.000 rs2606329 chr4:154654643 A/C cg14289246 chr4:154710475 SFRP2 0.49 6.11 0.32 2.74e-9 Response to statins (LDL cholesterol change); LUSC trans rs2228479 0.557 rs12933317 chr16:89828220 A/G cg24644049 chr4:85504048 CDS1 0.88 7.56 0.38 4e-13 Skin colour saturation; LUSC cis rs7937682 0.889 rs10789844 chr11:111579109 A/T cg09085632 chr11:111637200 PPP2R1B -1.12 -18.79 -0.72 3.08e-54 Primary sclerosing cholangitis; LUSC cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg06064525 chr11:970664 AP2A2 -0.49 -10.73 -0.51 2.85e-23 Alzheimer's disease (late onset); LUSC trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg27661571 chr11:113659931 NA -0.71 -8.0 -0.4 2.07e-14 Hip circumference adjusted for BMI; LUSC cis rs4776059 0.798 rs4776063 chr15:52904046 C/A cg22715398 chr15:52968154 KIAA1370 -0.6 -7.79 -0.39 8.29e-14 Schizophrenia; LUSC cis rs6121246 0.865 rs6089055 chr20:30324045 C/T cg21427119 chr20:30132790 HM13 -0.39 -5.71 -0.3 2.45e-8 Mean corpuscular hemoglobin; LUSC trans rs2832077 1.000 rs2832065 chr21:30135362 C/T cg14791747 chr16:20752902 THUMPD1 0.73 9.57 0.46 2.51e-19 Cognitive test performance; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.54 9.09 0.45 8.9e-18 Prudent dietary pattern; LUSC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC cis rs7312933 0.558 rs11181467 chr12:42765250 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 6.95 0.36 1.88e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg24399712 chr22:39784796 NA -0.56 -8.82 -0.43 6.33e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg12463550 chr7:65579703 CRCP 0.63 5.7 0.3 2.7e-8 Diabetic kidney disease; LUSC trans rs7556950 0.572 rs61554827 chr2:41932102 T/C cg13792581 chr20:43590115 TOMM34 0.77 6.26 0.32 1.17e-9 Major depression and alcohol dependence; LUSC cis rs4494114 0.967 rs1886748 chr1:39333775 C/A cg25970120 chr1:39325951 RRAGC -0.42 -6.41 -0.33 4.92e-10 Blood protein levels; LUSC trans rs10411161 0.702 rs8113584 chr19:52383874 A/G cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.78 -0.3 1.67e-8 Alzheimer's disease (late onset); LUSC cis rs4786125 0.665 rs1565634 chr16:6919370 T/C cg03623568 chr16:6915990 A2BP1 -0.5 -8.39 -0.42 1.38e-15 Heart rate variability traits (SDNN); LUSC cis rs10886558 0.517 rs9732120 chr10:121800656 A/T cg02041677 chr10:121771263 NA 0.37 6.93 0.35 2.2e-11 Shingles; LUSC cis rs7712401 0.601 rs246306 chr5:122279218 G/C cg19077854 chr5:122220652 SNX24 0.41 9.15 0.45 5.72e-18 Mean platelet volume; LUSC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg02038168 chr22:39784481 NA -0.47 -7.53 -0.38 4.64e-13 Intelligence (multi-trait analysis); LUSC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg09323728 chr8:95962352 TP53INP1 -0.3 -5.69 -0.3 2.78e-8 Type 2 diabetes; LUSC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg23958373 chr8:599963 NA -0.89 -9.02 -0.44 1.52e-17 IgG glycosylation; LUSC cis rs1044826 1.000 rs973691 chr3:139197858 G/C cg00490450 chr3:139108681 COPB2 0.52 6.76 0.35 6.18e-11 Obesity-related traits; LUSC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.84 -13.65 -0.6 5.08e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.58 -8.53 -0.42 5.17e-16 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.34e-17 Motion sickness; LUSC cis rs9905704 0.647 rs10221208 chr17:57047885 T/C cg12560992 chr17:57184187 TRIM37 0.6 9.58 0.46 2.23e-19 Testicular germ cell tumor; LUSC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg16325326 chr1:53192061 ZYG11B -0.89 -16.48 -0.67 4.45e-45 Monocyte count; LUSC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.87 0.68 1.25e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7824557 0.527 rs2736296 chr8:11234844 G/A cg21775007 chr8:11205619 TDH -0.65 -10.34 -0.49 6.55e-22 Retinal vascular caliber; LUSC cis rs3740540 0.507 rs942014 chr10:126290070 C/T cg04949429 chr10:126290192 LHPP 0.35 7.46 0.38 7.61e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg11752832 chr7:134001865 SLC35B4 0.51 7.72 0.39 1.33e-13 Mean platelet volume; LUSC cis rs3008870 1.000 rs3008856 chr1:67387901 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.94 14.83 0.63 1.39e-38 Lymphocyte percentage of white cells; LUSC cis rs11112613 0.609 rs4991814 chr12:106046709 G/A cg03607813 chr12:105948248 NA 0.62 7.84 0.39 6.02e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs1790761 0.554 rs12787511 chr11:67401635 G/C cg00290607 chr11:67383545 NA -0.38 -6.42 -0.33 4.74e-10 Mean corpuscular volume; LUSC cis rs1595825 0.891 rs60484833 chr2:198812181 C/T cg10547527 chr2:198650123 BOLL -0.5 -5.92 -0.31 7.84e-9 Ulcerative colitis; LUSC cis rs2692947 0.644 rs772178 chr2:96963684 C/T cg23100626 chr2:96804247 ASTL -0.29 -6.87 -0.35 3.09e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1577917 1.000 rs1577917 chr6:86691940 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.88 -0.35 3.05e-11 Response to antipsychotic treatment; LUSC cis rs9287719 0.967 rs4284804 chr2:10722124 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.96e-9 Prostate cancer; LUSC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg15921436 chr17:44337874 NA 0.83 11.86 0.54 2.54e-27 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.31 -5.85 -0.3 1.19e-8 Lymphocyte counts; LUSC cis rs654351 0.572 rs813274 chr6:10387731 C/T cg17959970 chr6:10383164 NA -0.36 -6.69 -0.34 9.31e-11 Squamous cell lung carcinoma; LUSC cis rs2425143 1.000 rs60646509 chr20:34303409 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.33 -0.33 8.1e-10 Blood protein levels; LUSC cis rs460214 0.564 rs464519 chr21:40024182 A/G cg12884169 chr21:40033163 ERG -0.35 -5.73 -0.3 2.25e-8 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.14 0.41 8.16e-15 Axial length; LUSC cis rs12950390 0.853 rs11079792 chr17:45863311 T/C cg03474202 chr17:45855739 NA -0.3 -6.99 -0.36 1.46e-11 IgG glycosylation; LUSC cis rs34526934 0.608 rs13017511 chr2:177035395 A/G cg26754761 chr2:177040938 NA -0.4 -7.72 -0.39 1.39e-13 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs72827839 0.516 rs72833461 chr17:45938105 T/G cg23391107 chr17:45924227 SP6 0.42 7.42 0.38 9.86e-13 Ease of getting up in the morning; LUSC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg11502198 chr6:26597334 ABT1 0.71 11.85 0.54 2.87e-27 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg01475377 chr6:109611718 NA -0.37 -6.46 -0.33 3.61e-10 Reticulocyte fraction of red cells; LUSC cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg16006841 chr5:176797999 RGS14 0.62 9.8 0.47 4.25e-20 Hemoglobin concentration;Hematocrit; LUSC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg19046167 chr17:80928561 B3GNTL1 -0.45 -6.49 -0.33 3.03e-10 Breast cancer; LUSC cis rs6960043 0.905 rs7786873 chr7:15060410 A/G cg19272540 chr7:15055459 NA -0.31 -7.32 -0.37 1.85e-12 Type 2 diabetes; LUSC trans rs853679 0.882 rs3757188 chr6:28107357 T/C cg06606381 chr12:133084897 FBRSL1 -0.67 -7.52 -0.38 5.13e-13 Depression; LUSC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg18477163 chr1:228402036 OBSCN -0.56 -10.27 -0.49 1.13e-21 Diastolic blood pressure; LUSC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg09034736 chr1:150693464 HORMAD1 -0.46 -6.34 -0.33 7.24e-10 Melanoma; LUSC cis rs354225 0.544 rs10208219 chr2:54806047 G/A cg26097391 chr2:54893211 SPTBN1 0.46 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs4474465 0.915 rs11237505 chr11:78171261 A/G cg27205649 chr11:78285834 NARS2 -0.49 -5.79 -0.3 1.6e-8 Alzheimer's disease (survival time); LUSC trans rs9929218 0.551 rs7201437 chr16:68727130 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 22.93 0.78 1.45e-70 Colorectal cancer; LUSC trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg15704280 chr7:45808275 SEPT13 0.75 8.5 0.42 6.55e-16 Axial length; LUSC cis rs9875589 0.509 rs4685051 chr3:13981760 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.13 0.36 6.15e-12 Ovarian reserve; LUSC cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs35146811 0.735 rs1637001 chr7:99808151 G/A cg19116668 chr7:99932089 PMS2L1 0.34 5.99 0.31 5.31e-9 Coronary artery disease; LUSC cis rs9399135 0.660 rs9389248 chr6:135282656 T/C cg24558204 chr6:135376177 HBS1L 0.57 8.61 0.43 2.87e-16 Red blood cell count; LUSC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg25767906 chr1:53392781 SCP2 -0.45 -7.9 -0.4 4e-14 Monocyte count; LUSC cis rs10108704 0.917 rs72682697 chr8:110348649 T/C cg20147595 chr8:110349212 ENY2 -0.45 -5.67 -0.3 3.14e-8 Multiple system atrophy (pathologically confirmed); LUSC cis rs11711311 0.955 rs9851812 chr3:113412362 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.62 0.34 1.39e-10 IgG glycosylation; LUSC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg12463550 chr7:65579703 CRCP -0.43 -6.16 -0.32 2.11e-9 Corneal structure; LUSC cis rs4343996 0.626 rs4722723 chr7:3398320 C/T cg21248987 chr7:3385318 SDK1 -0.37 -6.21 -0.32 1.61e-9 Motion sickness; LUSC cis rs977987 0.806 rs11648176 chr16:75456423 C/G cg03315344 chr16:75512273 CHST6 0.5 9.36 0.46 1.2e-18 Dupuytren's disease; LUSC cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.17 -0.32 1.94e-9 Bipolar disorder; LUSC cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg21433313 chr16:3507492 NAT15 0.41 6.35 0.33 6.97e-10 Body mass index (adult); LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg16393715 chr7:1948819 MAD1L1 0.4 6.92 0.35 2.35e-11 Bipolar disorder and schizophrenia; LUSC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg23281280 chr6:28129359 ZNF389 0.45 5.67 0.3 3.04e-8 Depression; LUSC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg12463550 chr7:65579703 CRCP 0.47 6.96 0.36 1.86e-11 Aortic root size; LUSC cis rs9517320 0.935 rs1886089 chr13:99124356 C/T cg20487152 chr13:99095054 FARP1 0.35 6.5 0.33 3.01e-10 Longevity; LUSC cis rs6121246 0.529 rs6060142 chr20:30178028 A/G cg21427119 chr20:30132790 HM13 -0.45 -6.52 -0.34 2.66e-10 Mean corpuscular hemoglobin; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00345230 chr4:151936469 LRBA 0.42 6.16 0.32 2.14e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.34 0.56 4.41e-29 Cognitive test performance; LUSC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg19622623 chr12:86230825 RASSF9 -0.45 -6.18 -0.32 1.87e-9 Major depressive disorder; LUSC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg24675658 chr1:53192096 ZYG11B -0.65 -10.18 -0.49 2.16e-21 Monocyte count; LUSC trans rs11681884 0.786 rs34466405 chr2:113808054 A/T cg19632953 chr13:113635898 MCF2L 0.7 6.06 0.31 3.63e-9 Stroke; LUSC cis rs1864400 0.696 rs2742239 chr10:43621712 A/G cg02780029 chr10:43622663 RET -0.33 -5.67 -0.3 3.01e-8 Hirschsprung disease; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg12569071 chr8:22102812 POLR3D;MIR320A 0.51 6.24 0.32 1.34e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10865541 0.869 rs13020433 chr2:3417577 G/A cg15807143 chr2:3452624 TTC15 0.33 5.84 0.3 1.21e-8 Obesity-related traits; LUSC cis rs9733 0.650 rs61820165 chr1:150555987 C/T cg13175981 chr1:150552382 MCL1 0.53 7.4 0.38 1.09e-12 Tonsillectomy; LUSC cis rs7572644 0.679 rs12986980 chr2:28030437 A/G cg27432699 chr2:27873401 GPN1 0.55 7.3 0.37 2.19e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -11.89 -0.55 2.04e-27 Platelet count; LUSC cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg12011299 chr4:100065546 ADH4 0.7 10.71 0.51 3.35e-23 Smoking initiation; LUSC cis rs17685 0.753 rs4732595 chr7:75755139 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.83 -0.39 6.43e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg06618935 chr21:46677482 NA -0.41 -8.0 -0.4 2.12e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9788682 1.000 rs2036534 chr15:78826948 T/C cg24631222 chr15:78858424 CHRNA5 0.84 11.33 0.53 2.16e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1559088 0.948 rs10406916 chr19:33590093 G/A cg17764715 chr19:33622953 WDR88 0.6 8.29 0.41 2.72e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg07952391 chr2:88470173 THNSL2 0.75 6.49 0.33 3.06e-10 Plasma clusterin levels; LUSC cis rs12220238 1.000 rs10824098 chr10:75943579 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.3 0.37 2.06e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2637266 1.000 rs2579746 chr10:78327674 C/T cg18941641 chr10:78392320 NA 0.37 6.79 0.35 5.01e-11 Pulmonary function; LUSC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.48 0.38 6.75e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg00631329 chr6:26305371 NA -0.47 -9.21 -0.45 3.71e-18 Educational attainment; LUSC cis rs977987 0.843 rs4146810 chr16:75415831 A/G cg03315344 chr16:75512273 CHST6 0.53 10.44 0.5 2.81e-22 Dupuytren's disease; LUSC cis rs9527 0.590 rs10786738 chr10:104869451 C/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs7712401 0.601 rs30038 chr5:122277362 A/C cg19077854 chr5:122220652 SNX24 0.41 9.09 0.45 8.76e-18 Mean platelet volume; LUSC cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.82 0.51 1.39e-23 Bone mineral density; LUSC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg20476274 chr7:133979776 SLC35B4 0.88 16.77 0.68 3.06e-46 Mean platelet volume; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.55 -0.53 3.41e-26 Alzheimer's disease; LUSC cis rs763121 0.889 rs1837988 chr22:38901094 A/G cg06022373 chr22:39101656 GTPBP1 0.77 11.58 0.54 2.61e-26 Menopause (age at onset); LUSC cis rs6754311 0.773 rs4988183 chr2:136622046 T/C cg07169764 chr2:136633963 MCM6 0.76 10.77 0.51 2.09e-23 Mosquito bite size; LUSC trans rs9393777 0.841 rs13191474 chr6:27413345 C/T cg06606381 chr12:133084897 FBRSL1 -1.02 -9.45 -0.46 6.1e-19 Intelligence (multi-trait analysis); LUSC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg12751644 chr20:60527061 NA -0.34 -6.0 -0.31 5.03e-9 Body mass index; LUSC cis rs1577917 0.958 rs10806337 chr6:86474249 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.12 -0.36 6.84e-12 Response to antipsychotic treatment; LUSC trans rs7746199 0.736 rs13192965 chr6:27671825 G/A cg01620082 chr3:125678407 NA -0.77 -6.9 -0.35 2.57e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.6 0.38 2.98e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11700980 0.551 rs2832034 chr21:30114927 T/C cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs7246657 0.941 rs67293224 chr19:37803248 C/T cg23950597 chr19:37808831 NA -0.62 -7.31 -0.37 2e-12 Coronary artery calcification; LUSC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg12386194 chr3:101231763 SENP7 0.53 7.4 0.38 1.08e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2458413 0.669 rs1812214 chr8:105344070 A/G cg04554929 chr8:105342491 NA -0.36 -6.4 -0.33 5.22e-10 Paget's disease; LUSC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg11245181 chr6:149772854 ZC3H12D 0.3 6.58 0.34 1.82e-10 Dupuytren's disease; LUSC cis rs17102423 0.826 rs10873181 chr14:65604459 A/C cg11161011 chr14:65562177 MAX -0.69 -10.54 -0.5 1.26e-22 Obesity-related traits; LUSC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg14262678 chr6:151773367 RMND1;C6orf211 0.45 7.36 0.37 1.47e-12 Menarche (age at onset); LUSC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg06221963 chr1:154839813 KCNN3 0.59 13.45 0.59 2.87e-33 Prostate cancer; LUSC cis rs68170813 0.559 rs80307895 chr7:106907781 T/A cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs9916302 0.706 rs582176 chr17:37453999 T/C cg07936489 chr17:37558343 FBXL20 0.78 9.96 0.48 1.27e-20 Glomerular filtration rate (creatinine); LUSC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg02175503 chr12:58329896 NA -0.41 -5.79 -0.3 1.6e-8 Multiple sclerosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24681695 chr2:170550946 C2orf77;PHOSPHO2;KLHL23 -0.42 -6.26 -0.32 1.17e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs68170813 0.559 rs74906766 chr7:106885236 T/A cg02696742 chr7:106810147 HBP1 -0.63 -9.48 -0.46 5.01e-19 Coronary artery disease; LUSC cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg01256987 chr12:42539512 GXYLT1 -0.45 -8.55 -0.42 4.46e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg11890956 chr21:40555474 PSMG1 0.85 10.47 0.5 2.22e-22 Cognitive function; LUSC cis rs7605378 1.000 rs10194076 chr2:200677663 T/C cg23649088 chr2:200775458 C2orf69 0.5 7.55 0.38 4.27e-13 Osteoporosis; LUSC cis rs6076065 0.683 rs2424528 chr20:23361613 C/T cg11657817 chr20:23433608 CST11 0.42 7.99 0.4 2.19e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs4285028 0.580 rs2293611 chr3:121643163 G/C cg11130432 chr3:121712080 ILDR1 -0.5 -8.33 -0.41 2.08e-15 Multiple sclerosis; LUSC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC cis rs7666738 0.546 rs10007424 chr4:98885450 C/T cg05340658 chr4:99064831 C4orf37 0.59 8.94 0.44 2.79e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg21643547 chr1:205240462 TMCC2 -0.53 -10.15 -0.49 2.88e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.67 -0.3 3.04e-8 Life satisfaction; LUSC cis rs59104589 0.550 rs62193172 chr2:242277715 G/C cg14842376 chr2:242211374 HDLBP 0.57 6.46 0.33 3.65e-10 Fibrinogen levels; LUSC cis rs9790314 0.967 rs336541 chr3:161056698 A/C cg03342759 chr3:160939853 NMD3 -0.49 -8.18 -0.41 5.82e-15 Morning vs. evening chronotype; LUSC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg24503407 chr1:205819492 PM20D1 0.44 6.07 0.32 3.42e-9 Parkinson's disease; LUSC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.71 0.47 8.46e-20 Bipolar disorder; LUSC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg06636001 chr8:8085503 FLJ10661 0.62 9.67 0.47 1.16e-19 Joint mobility (Beighton score); LUSC cis rs4820539 0.902 rs737846 chr22:23460669 A/G cg21100191 chr22:23484243 RTDR1 0.92 15.74 0.65 3.94e-42 Bone mineral density; LUSC cis rs4478858 0.735 rs7523509 chr1:31788329 A/G cg00250761 chr1:31883323 NA -0.36 -8.92 -0.44 3.03e-17 Alcohol dependence; LUSC trans rs8002861 0.905 rs11617551 chr13:44443977 T/C cg12856521 chr11:46389249 DGKZ -0.38 -6.08 -0.32 3.23e-9 Leprosy; LUSC cis rs9300255 0.782 rs12809602 chr12:123768916 T/G cg13010344 chr12:123464640 ARL6IP4 0.55 6.75 0.35 6.75e-11 Neutrophil percentage of white cells; LUSC cis rs79387448 0.808 rs77518775 chr2:103237642 T/C cg09003973 chr2:102972529 NA 0.69 6.86 0.35 3.37e-11 Gut microbiota (bacterial taxa); LUSC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.97 0.48 1.19e-20 Bipolar disorder; LUSC cis rs2439831 0.681 rs3742971 chr15:43622916 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.9 -10.62 -0.5 6.96e-23 Lung cancer in ever smokers; LUSC cis rs1008375 1.000 rs11947857 chr4:17691047 T/C cg18681998 chr4:17616180 MED28 -0.86 -15.42 -0.64 6.85e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg25282410 chr6:160211355 TCP1;MRPL18 1.07 16.54 0.67 2.67e-45 Age-related macular degeneration (geographic atrophy); LUSC cis rs11098499 0.570 rs6832740 chr4:120546136 T/C cg24375607 chr4:120327624 NA 0.72 11.39 0.53 1.28e-25 Corneal astigmatism; LUSC cis rs9309473 1.000 rs6711033 chr2:73746643 T/C cg20560298 chr2:73613845 ALMS1 -0.42 -6.04 -0.31 4.18e-9 Metabolite levels; LUSC cis rs62400317 0.826 rs4400216 chr6:45237955 T/G cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs2279817 0.820 rs924686 chr1:18027726 C/A cg21791023 chr1:18019539 ARHGEF10L 0.43 6.02 0.31 4.54e-9 Neuroticism; LUSC cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg24642439 chr20:33292090 TP53INP2 0.51 7.64 0.39 2.32e-13 Height; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14959291 chr3:96532006 EPHA6 -0.43 -6.84 -0.35 3.78e-11 Triglycerides; LUSC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg26897989 chr16:1907736 C16orf73 -0.42 -6.63 -0.34 1.37e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs782590 0.774 rs782630 chr2:55899425 T/C cg18811423 chr2:55921094 PNPT1 0.89 15.83 0.65 1.63e-42 Metabolic syndrome; LUSC cis rs533581 0.866 rs502258 chr16:88968547 G/A cg08484992 chr16:88977278 CBFA2T3 0.35 6.13 0.32 2.46e-9 Social autistic-like traits; LUSC cis rs68170813 0.559 rs7798223 chr7:106829223 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.63 -0.47 1.54e-19 Coronary artery disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03191565 chr19:47987374 KPTN -0.43 -6.22 -0.32 1.5e-9 Electrocardiographic conduction measures; LUSC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg06636001 chr8:8085503 FLJ10661 0.51 7.9 0.4 4.11e-14 Joint mobility (Beighton score); LUSC cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs6546886 0.957 rs4853005 chr2:74258049 G/C cg14702570 chr2:74259524 NA -0.31 -5.91 -0.31 8.36e-9 Dialysis-related mortality; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09151521 chr3:137834591 DZIP1L 0.4 6.04 0.31 4.22e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs208520 0.954 rs72884027 chr6:66995044 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 11.93 0.55 1.4e-27 Exhaled nitric oxide output; LUSC cis rs1372520 0.748 rs2737002 chr4:90753180 A/G cg14346243 chr4:90757452 SNCA -0.42 -6.06 -0.31 3.59e-9 Neuroticism; LUSC cis rs9467773 1.000 rs9393729 chr6:26514166 C/T cg11502198 chr6:26597334 ABT1 0.6 9.37 0.46 1.12e-18 Intelligence (multi-trait analysis); LUSC cis rs11997175 1.000 rs10453046 chr8:33773179 T/C ch.8.33884649F chr8:33765107 NA 0.53 8.5 0.42 6.26e-16 Body mass index; LUSC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg06850241 chr22:41845214 NA 0.33 6.0 0.31 5.1e-9 Vitiligo; LUSC cis rs1256061 0.603 rs1256038 chr14:64740739 T/C cg23250157 chr14:64679961 SYNE2 0.32 5.7 0.3 2.68e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7527798 0.592 rs12025522 chr1:207854355 A/C cg09232269 chr1:207846808 CR1L 0.28 6.08 0.32 3.33e-9 Erythrocyte sedimentation rate; LUSC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg15316289 chr22:50310904 ALG12;CRELD2 0.46 6.83 0.35 4.02e-11 Schizophrenia; LUSC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg20135002 chr11:47629003 NA -0.52 -8.0 -0.4 2.05e-14 Subjective well-being; LUSC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg12826209 chr6:26865740 GUSBL1 0.76 9.18 0.45 4.6e-18 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12667521 chr19:29218732 NA 0.62 9.4 0.46 8.75e-19 Methadone dose in opioid dependence; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09964670 chr19:5720572 TMEM146;LONP1 -0.44 -6.04 -0.31 4.22e-9 Bipolar disorder and schizophrenia; LUSC cis rs2742234 0.955 rs2503841 chr10:43675721 C/T cg02780029 chr10:43622663 RET -0.35 -6.68 -0.34 9.99e-11 Hirschsprung disease; LUSC cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg06064525 chr11:970664 AP2A2 -0.35 -7.02 -0.36 1.22e-11 Alzheimer's disease (late onset); LUSC cis rs9467773 1.000 rs6922824 chr6:26553815 C/G cg09904177 chr6:26538194 HMGN4 -0.73 -13.7 -0.6 3.28e-34 Intelligence (multi-trait analysis); LUSC cis rs9840812 0.861 rs1153871 chr3:135954599 T/C cg15507776 chr3:136538369 TMEM22 0.42 5.93 0.31 7.63e-9 Fibrinogen levels; LUSC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.42 -0.33 4.7e-10 Personality dimensions; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07449447 chr14:55228808 SAMD4A -0.38 -6.86 -0.35 3.31e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs258324 0.790 rs258318 chr16:89732050 T/C cg04287289 chr16:89883240 FANCA -0.68 -6.1 -0.32 2.91e-9 Height; LUSC cis rs17604090 1.000 rs10272065 chr7:29694236 A/T cg19413766 chr7:29689036 LOC646762 -0.62 -7.44 -0.38 8.54e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs1670533 0.818 rs6835141 chr4:1070140 G/T cg02018176 chr4:1364513 KIAA1530 0.45 6.4 0.33 5.18e-10 Recombination rate (females); LUSC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg14558114 chr2:88469736 THNSL2 0.78 7.07 0.36 9.21e-12 Plasma clusterin levels; LUSC cis rs11098499 0.644 rs7676296 chr4:120555687 A/G cg24375607 chr4:120327624 NA 0.72 11.4 0.53 1.23e-25 Corneal astigmatism; LUSC cis rs4285028 0.948 rs2877560 chr3:121699238 C/A cg11130432 chr3:121712080 ILDR1 -0.65 -9.82 -0.47 3.69e-20 Multiple sclerosis; LUSC cis rs12893668 0.673 rs2296482 chr14:104029819 T/G cg08213375 chr14:104286397 PPP1R13B 0.38 6.14 0.32 2.35e-9 Reticulocyte count; LUSC cis rs17270561 0.609 rs9379788 chr6:25742759 A/C cg16482183 chr6:26056742 HIST1H1C 0.63 9.05 0.44 1.24e-17 Iron status biomarkers; LUSC cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.03 0.55 6.29e-28 Motion sickness; LUSC cis rs67311347 0.713 rs114569261 chr3:40314580 G/A cg17264618 chr3:40429014 ENTPD3 0.29 6.27 0.32 1.14e-9 Renal cell carcinoma; LUSC cis rs7223966 0.921 rs2006123 chr17:61958669 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.16 0.36 5.3e-12 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9815354 0.680 rs57525756 chr3:41843591 A/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs66887589 0.967 rs1155577 chr4:120449810 C/T cg24375607 chr4:120327624 NA -0.45 -6.96 -0.36 1.86e-11 Diastolic blood pressure; LUSC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs4919087 0.926 rs7072078 chr10:99026509 G/A cg25902810 chr10:99078978 FRAT1 0.44 6.3 0.33 9.18e-10 Monocyte count; LUSC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg05802129 chr4:122689817 NA -0.37 -6.54 -0.34 2.29e-10 Type 2 diabetes; LUSC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg12927641 chr6:109611667 NA -0.41 -7.22 -0.37 3.52e-12 Reticulocyte fraction of red cells; LUSC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.93 0.48 1.54e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10045504 0.502 rs72746032 chr5:38743982 T/C cg15396434 chr5:38725168 NA -0.51 -5.73 -0.3 2.29e-8 Night sleep phenotypes; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22338127 chr1:209979572 IRF6 0.63 11.26 0.52 3.75e-25 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg06112835 chr11:68658793 MRPL21 0.52 8.08 0.4 1.21e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.92 0.4 3.59e-14 Colorectal cancer; LUSC cis rs1595825 0.786 rs74484541 chr2:198894223 T/C cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC trans rs9650657 0.655 rs10093774 chr8:10703293 C/T cg15556689 chr8:8085844 FLJ10661 0.43 6.49 0.33 3.12e-10 Neuroticism; LUSC trans rs11671005 0.504 rs3794964 chr19:59070916 T/C cg22037779 chr5:139682734 PFDN1 -0.57 -7.4 -0.38 1.15e-12 Mean platelet volume; LUSC cis rs924607 0.898 rs1697990 chr5:626278 A/G cg09021430 chr5:549028 NA 0.39 7.11 0.36 7.29e-12 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg05535760 chr7:792225 HEATR2 0.81 9.48 0.46 4.93e-19 Cerebrospinal P-tau181p levels; LUSC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg18681998 chr4:17616180 MED28 0.84 15.62 0.65 1.13e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3806843 0.547 rs246010 chr5:140336635 A/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs868036 0.718 rs28675295 chr15:68116400 C/A cg05925327 chr15:68127851 NA -0.38 -5.99 -0.31 5.48e-9 Restless legs syndrome; LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg07395648 chr5:131743802 NA -0.39 -5.86 -0.31 1.11e-8 Breast cancer; LUSC cis rs9348739 1 rs9348739 chr6:26923099 G/C cg09904177 chr6:26538194 HMGN4 -0.64 -6.29 -0.33 9.82e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9902453 0.791 rs2729451 chr17:28131334 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -9.32 -0.45 1.6e-18 Coffee consumption (cups per day); LUSC cis rs1595825 1.000 rs61605589 chr2:198876532 T/C cg00982548 chr2:198649783 BOLL -0.51 -6.31 -0.33 8.95e-10 Ulcerative colitis; LUSC cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg26597838 chr10:835615 NA 0.57 7.41 0.38 1.02e-12 Eosinophil percentage of granulocytes; LUSC trans rs17685 0.515 rs111240556 chr7:75600863 T/C cg19862616 chr7:65841803 NCRNA00174 0.46 6.14 0.32 2.35e-9 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1524927 1.000 rs1524927 chr7:96371732 C/T cg03808172 chr7:96339361 SHFM1 -0.41 -6.41 -0.33 5.01e-10 Total body bone mineral density; LUSC trans rs35110281 0.782 rs9981291 chr21:45031458 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.54 0.53 3.8e-26 Mean corpuscular volume; LUSC cis rs7909074 0.933 rs879073 chr10:45399882 C/G cg04218760 chr10:45406644 TMEM72 -0.28 -6.76 -0.35 6.15e-11 Mean corpuscular volume; LUSC cis rs1865760 0.865 rs1541987 chr6:25950397 A/G cg17691542 chr6:26056736 HIST1H1C -0.47 -7.02 -0.36 1.26e-11 Height; LUSC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg03806693 chr22:41940476 POLR3H 1.0 14.26 0.62 2.35e-36 Crohn's disease;Inflammatory bowel disease; LUSC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg13628971 chr7:2884303 GNA12 0.5 6.92 0.35 2.25e-11 Height; LUSC cis rs7824557 0.606 rs2736270 chr8:11192593 G/A cg21775007 chr8:11205619 TDH 0.78 12.47 0.56 1.4e-29 Retinal vascular caliber; LUSC cis rs6960043 0.936 rs62448618 chr7:15052211 T/A cg19272540 chr7:15055459 NA -0.29 -6.94 -0.35 2.05e-11 Type 2 diabetes; LUSC cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg07741184 chr6:167504864 NA 0.39 7.01 0.36 1.29e-11 Crohn's disease; LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.48 -6.61 -0.34 1.56e-10 Renal function-related traits (BUN); LUSC cis rs10740039 0.810 rs7098097 chr10:62364991 G/A cg18175470 chr10:62150864 ANK3 -0.47 -7.08 -0.36 8.72e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs72634258 0.786 rs9434993 chr1:8179744 G/C cg00042356 chr1:8021962 PARK7 0.54 6.55 0.34 2.23e-10 Inflammatory bowel disease; LUSC cis rs11039100 0.607 rs11038939 chr11:5777395 G/A cg05234568 chr11:5960015 NA -0.42 -5.68 -0.3 2.97e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs8072100 0.875 rs62073966 chr17:45600013 T/A cg08085267 chr17:45401833 C17orf57 0.6 9.83 0.47 3.5e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs35771425 0.600 rs6667063 chr1:211660746 G/A cg10512769 chr1:211675356 NA -0.27 -6.19 -0.32 1.76e-9 Educational attainment (years of education); LUSC cis rs7223966 1.000 rs8078462 chr17:61857937 T/G cg00945038 chr17:61921165 SMARCD2 0.4 6.03 0.31 4.3e-9 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs10435719 0.902 rs7459545 chr8:11804389 G/T cg08975724 chr8:8085496 FLJ10661 0.46 6.65 0.34 1.22e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9486715 0.867 rs1855533 chr6:97050265 T/C cg06623918 chr6:96969491 KIAA0776 -0.95 -18.42 -0.71 8.69e-53 Headache; LUSC cis rs684232 0.666 rs423887 chr17:593600 A/G cg12384639 chr17:618140 VPS53 0.36 5.65 0.3 3.51e-8 Prostate cancer; LUSC cis rs7927771 0.524 rs7114813 chr11:47801101 A/G cg20307385 chr11:47447363 PSMC3 0.44 6.43 0.33 4.36e-10 Subjective well-being; LUSC cis rs9811920 0.809 rs793476 chr3:99541747 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.41 -6.01 -0.31 4.84e-9 Axial length; LUSC cis rs6964587 0.869 rs401 chr7:91527945 T/G cg17063962 chr7:91808500 NA -0.53 -8.18 -0.41 6.04e-15 Breast cancer; LUSC cis rs6494488 0.500 rs72742957 chr15:64905227 A/C cg08069370 chr15:64387884 SNX1 -0.65 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs73198271 0.681 rs11987924 chr8:8649972 T/C cg01851573 chr8:8652454 MFHAS1 0.53 8.49 0.42 7.11e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11098499 0.780 rs7680914 chr4:120563053 A/G cg24375607 chr4:120327624 NA 0.75 10.86 0.51 9.79e-24 Corneal astigmatism; LUSC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.63 9.69 0.47 9.58e-20 Cognitive test performance; LUSC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg23711669 chr6:146136114 FBXO30 -0.92 -17.44 -0.69 7.11e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs1775715 0.737 rs2808028 chr10:32101189 G/A cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.68e-11 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs13390641 0.614 rs67403844 chr2:104079582 G/A cg03260781 chr1:16346299 HSPB7 -0.46 -6.09 -0.32 3.14e-9 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs3733418 0.929 rs13120990 chr4:165905118 A/G cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -5.93 -0.31 7.54e-9 Obesity-related traits; LUSC cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs2439831 0.681 rs7168940 chr15:43633334 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.9 10.67 0.5 4.65e-23 Lung cancer in ever smokers; LUSC cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 5.04e-15 Alzheimer's disease; LUSC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08704250 chr15:31115839 NA 0.46 7.01 0.36 1.32e-11 Huntington's disease progression; LUSC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg19774624 chr17:42201019 HDAC5 -0.77 -11.73 -0.54 7.6e-27 Total body bone mineral density; LUSC cis rs941408 1.000 rs1736180 chr19:2796021 C/T cg06609049 chr19:2785107 THOP1 0.68 10.65 0.5 5.51e-23 Total cholesterol levels; LUSC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11690935 0.571 rs13020884 chr2:172901699 T/G cg13550731 chr2:172543902 DYNC1I2 0.52 8.08 0.4 1.22e-14 Schizophrenia; LUSC cis rs929354 0.772 rs3802120 chr7:156977794 C/T cg05182265 chr7:156933206 UBE3C -0.59 -9.46 -0.46 5.85e-19 Body mass index; LUSC cis rs12200782 1.000 rs3800304 chr6:26598798 G/A cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.51e-8 Small cell lung carcinoma; LUSC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg12311346 chr5:56204834 C5orf35 -0.83 -12.91 -0.58 3.15e-31 Initial pursuit acceleration; LUSC cis rs73206853 0.841 rs73191834 chr12:110963841 T/G cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs4927850 1.000 rs7614767 chr3:195753451 C/T cg21051086 chr3:73046214 PPP4R2 -0.47 -7.21 -0.37 3.82e-12 Pancreatic cancer; LUSC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg23719950 chr11:63933701 MACROD1 -0.6 -7.86 -0.4 5.33e-14 Mean platelet volume; LUSC cis rs12464483 0.524 rs4952173 chr2:30888346 G/T cg07150166 chr2:30669952 LCLAT1 0.55 6.53 0.34 2.44e-10 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs9326248 0.911 rs474339 chr11:117059552 G/A cg11861562 chr11:117069780 TAGLN 0.45 8.08 0.4 1.2e-14 Blood protein levels; LUSC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg11764359 chr7:65958608 NA 0.78 13.01 0.58 1.41e-31 Aortic root size; LUSC cis rs9486719 1.000 rs2064947 chr6:97052754 C/T cg06623918 chr6:96969491 KIAA0776 -0.79 -10.18 -0.49 2.21e-21 Migraine;Coronary artery disease; LUSC cis rs7804356 1.000 rs13438513 chr7:26860633 C/G cg03456212 chr7:26904342 SKAP2 0.55 6.37 0.33 6.39e-10 Type 1 diabetes; LUSC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg22875332 chr1:76189707 ACADM 0.8 12.63 0.57 3.53e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6062509 0.895 rs6011040 chr20:62337406 C/T cg02966332 chr20:62369605 LIME1 0.38 5.99 0.31 5.42e-9 Prostate cancer; LUSC trans rs11098499 0.754 rs12506610 chr4:120241659 T/C cg25214090 chr10:38739885 LOC399744 0.43 6.58 0.34 1.77e-10 Corneal astigmatism; LUSC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.67 0.47 1.18e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg01652190 chr22:50026171 C22orf34 -0.31 -6.39 -0.33 5.51e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg22029157 chr1:209979665 IRF6 0.73 8.59 0.43 3.46e-16 Coronary artery disease; LUSC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg21951975 chr1:209979733 IRF6 0.61 7.89 0.4 4.43e-14 Cleft lip with or without cleft palate; LUSC cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg11266682 chr4:10021025 SLC2A9 0.5 8.77 0.43 8.96e-17 Bone mineral density; LUSC cis rs6138458 0.828 rs6132785 chr20:24993414 T/C cg06937882 chr20:24974362 C20orf3 -0.33 -5.95 -0.31 6.75e-9 Blood protein levels; LUSC cis rs10779751 0.770 rs6674994 chr1:11239515 T/C cg08854313 chr1:11322531 MTOR 0.87 13.93 0.61 4.14e-35 Body mass index; LUSC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg16339924 chr4:17578868 LAP3 0.55 8.23 0.41 4.39e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7011049 1.000 rs10958336 chr8:53841318 G/A cg26025543 chr8:53854495 NA 0.53 6.4 0.33 5.18e-10 Systolic blood pressure; LUSC cis rs9311676 0.609 rs11719450 chr3:58456811 A/G cg13750441 chr3:58318267 PXK -0.35 -6.64 -0.34 1.25e-10 Systemic lupus erythematosus; LUSC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs10186029 0.582 rs1441165 chr2:214009831 A/G cg08319019 chr2:214017104 IKZF2 0.49 6.7 0.34 9.06e-11 Systemic sclerosis; LUSC cis rs9788682 0.747 rs3743078 chr15:78894759 C/G cg24631222 chr15:78858424 CHRNA5 -0.69 -9.76 -0.47 5.78e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg15145296 chr3:125709740 NA -0.55 -6.57 -0.34 1.89e-10 Blood pressure (smoking interaction); LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg10729496 chr3:10149963 C3orf24 0.55 7.21 0.37 3.79e-12 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03646922 chr17:4167316 ANKFY1 0.4 6.28 0.32 1.07e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2197308 0.631 rs4882308 chr12:38446252 G/C cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.06e-10 Morning vs. evening chronotype; LUSC cis rs76419734 0.510 rs17036102 chr4:106603098 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.67 -8.36 -0.42 1.68e-15 Post bronchodilator FEV1; LUSC cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg09998033 chr7:158218633 PTPRN2 -0.61 -9.8 -0.47 4.15e-20 Obesity-related traits; LUSC cis rs7914558 1.000 rs7896547 chr10:104866958 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.58 0.46 2.38e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg18758796 chr5:131593413 PDLIM4 0.42 6.79 0.35 5.01e-11 Acylcarnitine levels; LUSC cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg00898013 chr13:113819073 PROZ -0.54 -7.93 -0.4 3.32e-14 Platelet distribution width; LUSC cis rs6960043 0.714 rs4719430 chr7:15047280 C/G cg19272540 chr7:15055459 NA -0.34 -8.76 -0.43 9.64e-17 Type 2 diabetes; LUSC cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg06481639 chr22:41940642 POLR3H -0.53 -5.96 -0.31 6.38e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg23583168 chr7:148888333 NA -0.86 -15.33 -0.64 1.51e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs2243480 1.000 rs2257790 chr7:65600450 C/T cg10756647 chr7:56101905 PSPH 0.89 8.94 0.44 2.61e-17 Diabetic kidney disease; LUSC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg11117266 chr17:43971461 MAPT;LOC100128977 -0.39 -5.8 -0.3 1.58e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3771570 0.901 rs869943 chr2:242431585 C/G cg21155796 chr2:242212141 HDLBP 0.61 6.84 0.35 3.83e-11 Prostate cancer; LUSC cis rs977987 0.806 rs11642572 chr16:75452782 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.37e-11 Dupuytren's disease; LUSC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -9.54 -0.46 3.1400000000000002e-19 Bipolar disorder and schizophrenia; LUSC trans rs801193 0.901 rs4273746 chr7:66301111 C/T cg18876405 chr7:65276391 NA -0.68 -11.68 -0.54 1.18e-26 Aortic root size; LUSC cis rs12900413 0.603 rs2351494 chr15:90299541 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.9 -0.31 8.76e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9311676 0.594 rs55954186 chr3:58436476 G/A cg26110898 chr3:58419937 PDHB 0.41 6.68 0.34 1.01e-10 Systemic lupus erythematosus; LUSC cis rs593982 1.000 rs1941746 chr11:65502413 A/G cg08755490 chr11:65554678 OVOL1 1.41 17.72 0.7 5.44e-50 Atopic dermatitis; LUSC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg05585544 chr11:47624801 NA -0.41 -7.24 -0.37 3.01e-12 Subjective well-being; LUSC cis rs9527 0.590 rs2066322 chr10:104909339 T/G cg05855489 chr10:104503620 C10orf26 0.52 7.93 0.4 3.25e-14 Arsenic metabolism; LUSC cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg13010199 chr12:38710504 ALG10B 0.68 10.71 0.51 3.28e-23 Bladder cancer; LUSC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9660992 0.573 rs12144980 chr1:205185104 C/T cg21545522 chr1:205238299 TMCC2 0.49 9.28 0.45 2.13e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6867913 0.561 rs9324864 chr5:141469000 A/G cg08523384 chr5:141488047 NDFIP1 0.43 6.97 0.36 1.74e-11 Asthma; LUSC cis rs3750965 0.959 rs3376 chr11:68856680 G/A cg06818126 chr11:68850279 TPCN2 -0.44 -6.42 -0.33 4.7e-10 Hair color; LUSC cis rs79349575 0.811 rs12601072 chr17:46997998 T/C cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.36e-13 Type 2 diabetes; LUSC cis rs2236521 0.714 rs6062210 chr20:60890375 A/G cg12382846 chr20:60892121 LAMA5 0.32 6.22 0.32 1.47e-9 Pelvic organ prolapse; LUSC cis rs826838 0.935 rs11169547 chr12:39185625 C/A cg26384229 chr12:38710491 ALG10B 0.89 16.7 0.67 5.82e-46 Heart rate; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.65 0.39 2.18e-13 Prudent dietary pattern; LUSC cis rs16866061 1.000 rs11686590 chr2:225334070 A/G cg12698349 chr2:225449008 CUL3 0.84 13.79 0.6 1.5e-34 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg01879757 chr17:41196368 BRCA1 -0.5 -7.85 -0.39 5.88e-14 Menopause (age at onset); LUSC cis rs56804039 1.000 rs6986470 chr8:8381430 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -6.29 -0.33 1.02e-9 Cervical cancer; LUSC cis rs6840360 0.571 rs4696279 chr4:152560449 G/A cg22705602 chr4:152727874 NA -0.3 -6.11 -0.32 2.83e-9 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg02269571 chr22:50332266 NA -0.59 -9.11 -0.45 7.8e-18 Schizophrenia; LUSC cis rs11608355 0.846 rs60945232 chr12:109854401 A/G cg05360138 chr12:110035743 NA 0.61 8.19 0.41 5.79e-15 Neuroticism; LUSC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg00990874 chr7:1149470 C7orf50 -0.61 -8.03 -0.4 1.66e-14 Bronchopulmonary dysplasia; LUSC cis rs4820539 0.641 rs5759602 chr22:23489362 C/T cg21100191 chr22:23484243 RTDR1 -0.66 -9.75 -0.47 6.1e-20 Bone mineral density; LUSC cis rs7267979 0.933 rs6138571 chr20:25435388 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.7 0.75 7.91e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7766436 0.885 rs1418311 chr6:22594964 T/G cg13666174 chr6:22585274 NA -0.41 -5.66 -0.3 3.18e-8 Coronary artery disease; LUSC cis rs2980439 0.607 rs2980419 chr8:8114141 A/T cg11608241 chr8:8085544 FLJ10661 0.44 6.2 0.32 1.64e-9 Neuroticism; LUSC cis rs2295359 0.963 rs12030867 chr1:67627620 T/C cg12940439 chr1:67600707 NA 0.36 6.11 0.32 2.76e-9 Psoriasis; LUSC cis rs9815354 0.904 rs73081347 chr3:41903582 T/C cg03022575 chr3:42003672 ULK4 0.83 8.67 0.43 1.88e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs4771122 0.728 rs1475221 chr13:28037566 C/T cg22138327 chr13:27999177 GTF3A -0.67 -8.77 -0.43 9.11e-17 Body mass index; LUSC cis rs2019216 0.521 rs9807074 chr17:21930856 T/C cg22648282 chr17:21454238 C17orf51 -0.53 -8.01 -0.4 1.96e-14 Pelvic organ prolapse; LUSC cis rs9790314 0.521 rs13084746 chr3:161086038 G/A cg03342759 chr3:160939853 NMD3 -0.41 -5.98 -0.31 5.71e-9 Morning vs. evening chronotype; LUSC cis rs1595825 0.838 rs58576043 chr2:198524149 C/T cg19156104 chr2:198669113 PLCL1 -0.45 -5.69 -0.3 2.74e-8 Ulcerative colitis; LUSC cis rs4478037 0.822 rs4320035 chr3:33113697 C/G cg19404215 chr3:33155277 CRTAP -0.93 -9.54 -0.46 2.99e-19 Major depressive disorder; LUSC cis rs2075165 0.901 rs1804999 chr1:156219450 A/G cg20302342 chr1:156215951 PAQR6 0.32 6.18 0.32 1.85e-9 Tonsillectomy; LUSC trans rs61931739 0.635 rs10743837 chr12:33982162 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.97 0.31 5.96e-9 Morning vs. evening chronotype; LUSC cis rs155346 1.000 rs265153 chr5:139380832 C/A cg01090482 chr5:139365336 NRG2 -0.4 -6.62 -0.34 1.43e-10 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs9788721 0.934 rs1051730 chr15:78894339 G/A cg18825076 chr15:78729989 IREB2 -0.51 -8.06 -0.4 1.4e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs7577851 0.595 rs67662551 chr2:69650445 T/A cg10773587 chr2:69614142 GFPT1 0.52 5.77 0.3 1.84e-8 Parkinson's disease (age of onset); LUSC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs6845621 0.727 rs12331530 chr4:18905938 T/C cg12196642 chr4:18937545 NA -0.33 -6.18 -0.32 1.85e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs17401966 0.540 rs11121566 chr1:10472848 C/G cg19773385 chr1:10388646 KIF1B -0.42 -7.28 -0.37 2.4e-12 Hepatocellular carcinoma; LUSC cis rs721399 0.553 rs13282367 chr8:18244986 T/G cg18736775 chr8:18248649 NAT2 -0.56 -6.57 -0.34 1.99e-10 Blood metabolite levels; LUSC cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg13770153 chr20:60521292 NA -0.59 -8.16 -0.41 6.74e-15 Body mass index; LUSC cis rs1443512 0.812 rs1975472 chr12:54337083 A/G cg17410650 chr12:54324560 NA -0.58 -9.94 -0.48 1.51e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs11039100 1.000 rs1470873 chr11:5827395 A/C cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg21918786 chr6:109611834 NA -0.36 -6.05 -0.31 3.89e-9 Reticulocyte fraction of red cells; LUSC cis rs9311676 0.656 rs6800514 chr3:58358717 C/T cg26110898 chr3:58419937 PDHB 0.45 7.2 0.37 4.08e-12 Systemic lupus erythematosus; LUSC cis rs9300255 0.602 rs1727315 chr12:123638930 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.37 6.17 0.32 2.03e-9 Neutrophil percentage of white cells; LUSC cis rs295137 0.798 rs1900706 chr2:201214071 A/C cg23649088 chr2:200775458 C2orf69 0.38 5.79 0.3 1.63e-8 Asthma (bronchodilator response); LUSC cis rs11229555 0.645 rs7926682 chr11:58189495 A/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6076065 0.723 rs16985308 chr20:23359780 A/T cg11657817 chr20:23433608 CST11 0.42 7.99 0.4 2.19e-14 Facial morphology (factor 15, philtrum width); LUSC trans rs12043259 1.000 rs6688709 chr1:204830071 C/T cg23865240 chr7:27134109 HOXA1 0.5 6.09 0.32 3.07e-9 Addiction; LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.04 -0.36 1.07e-11 Bipolar disorder; LUSC cis rs7189233 0.955 rs72801853 chr16:53516824 A/G cg04059762 chr16:53544020 NA -0.32 -5.64 -0.3 3.57e-8 Intelligence (multi-trait analysis); LUSC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg10664184 chr19:17420304 DDA1 0.46 5.7 0.3 2.6e-8 Systemic lupus erythematosus; LUSC cis rs11971779 0.616 rs6949963 chr7:139054325 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1535500 0.905 rs2146262 chr6:39283793 C/T cg03252829 chr6:39282164 KCNK17 -0.33 -5.84 -0.3 1.21e-8 Type 2 diabetes; LUSC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.85 0.3 1.2e-8 Tonsillectomy; LUSC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg04756594 chr16:24857601 SLC5A11 -0.49 -7.21 -0.37 3.79e-12 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs354225 0.554 rs10166844 chr2:54798272 T/C cg01766943 chr2:54829624 SPTBN1 0.49 7.82 0.39 7.15e-14 Schizophrenia; LUSC cis rs7903847 0.596 rs11189203 chr10:99159096 C/A cg20016023 chr10:99160130 RRP12 -0.31 -7.75 -0.39 1.12e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.52 7.86 0.39 5.5e-14 Bipolar disorder; LUSC cis rs7312933 0.558 rs11181463 chr12:42763636 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.14 0.36 5.77e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs259282 0.813 rs259250 chr19:33149216 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.71 10.54 0.5 1.35e-22 Schizophrenia; LUSC cis rs7927771 0.524 rs7107792 chr11:47669249 A/C cg18512352 chr11:47633146 NA 0.28 5.85 0.3 1.16e-8 Subjective well-being; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04856841 chr1:156308275 CCT3;C1orf182 -0.4 -6.01 -0.31 4.73e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -6.04 -0.31 4.03e-9 Intelligence (multi-trait analysis); LUSC cis rs1728785 0.892 rs1617749 chr16:68580890 A/G cg02972257 chr16:68554789 NA -0.49 -6.35 -0.33 7.09e-10 Ulcerative colitis; LUSC cis rs2273669 0.667 rs76430494 chr6:109350128 C/A cg05315195 chr6:109294784 ARMC2 -0.52 -5.64 -0.3 3.53e-8 Prostate cancer; LUSC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.71e-13 Electroencephalogram traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00230899 chr16:89766723 SPATA2L -0.42 -6.2 -0.32 1.64e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg22920501 chr2:26401640 FAM59B -0.73 -10.41 -0.5 3.53e-22 Gut microbiome composition (summer); LUSC cis rs7824557 0.603 rs6995404 chr8:11182148 C/G cg21775007 chr8:11205619 TDH 0.75 12.7 0.57 2.03e-30 Retinal vascular caliber; LUSC cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg04727924 chr7:799746 HEATR2 -0.55 -6.57 -0.34 1.98e-10 Cerebrospinal P-tau181p levels; LUSC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg12310025 chr6:25882481 NA -0.5 -8.53 -0.42 5.22e-16 Intelligence (multi-trait analysis); LUSC cis rs6674970 0.966 rs10788800 chr1:151104950 G/A cg03258749 chr1:151040405 MLLT11 -0.43 -6.55 -0.34 2.18e-10 Childhood ear infection; LUSC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg25427524 chr10:38739819 LOC399744 -0.68 -12.2 -0.56 1.43e-28 Extrinsic epigenetic age acceleration; LUSC cis rs6964587 1.000 rs6969536 chr7:91689351 C/G cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC trans rs2392780 0.536 rs622556 chr8:128333197 C/T cg10897648 chr18:56338258 MALT1 0.41 6.31 0.33 8.66e-10 Breast cancer (early onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16636271 chr6:139694487 CITED2 -0.56 -6.57 -0.34 1.98e-10 Bipolar disorder and schizophrenia; LUSC cis rs10186029 0.680 rs1530238 chr2:213957928 G/C cg08319019 chr2:214017104 IKZF2 0.55 7.98 0.4 2.43e-14 Systemic sclerosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07224438 chr2:97426485 CNNM4 0.49 6.73 0.35 7.29e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg11941060 chr3:133502564 NA -0.47 -6.79 -0.35 5.27e-11 Iron status biomarkers; LUSC cis rs6969780 1.000 rs6973182 chr7:27172321 C/T cg26364809 chr7:27145159 NA -0.58 -5.97 -0.31 5.98e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg00012203 chr2:219082015 ARPC2 -0.76 -13.09 -0.58 6.86e-32 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg13319975 chr6:146136371 FBXO30 -0.5 -7.54 -0.38 4.37e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1371867 0.810 rs2919470 chr8:101233301 C/A cg06636551 chr8:101224915 SPAG1 0.46 8.47 0.42 7.81e-16 Atrioventricular conduction; LUSC cis rs2354432 0.607 rs59606861 chr1:146761478 G/A cg25205988 chr1:146714368 CHD1L -0.99 -9.14 -0.45 6.32e-18 Mitochondrial DNA levels; LUSC cis rs12900413 0.603 rs7177841 chr15:90302117 C/A cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.92e-21 Monocyte count; LUSC cis rs7246657 0.943 rs10405325 chr19:37883477 G/C cg23950597 chr19:37808831 NA -0.64 -7.61 -0.38 2.77e-13 Coronary artery calcification; LUSC cis rs9653442 0.545 rs4490209 chr2:100766711 C/G cg07810366 chr2:100720526 AFF3 -0.44 -7.54 -0.38 4.45e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4654899 0.758 rs7521711 chr1:21400218 A/G cg01072550 chr1:21505969 NA -0.51 -7.77 -0.39 9.76e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg19622623 chr12:86230825 RASSF9 -0.44 -6.21 -0.32 1.62e-9 Major depressive disorder; LUSC cis rs983392 0.679 rs611418 chr11:60011013 C/T cg24026212 chr11:59952134 MS4A6A 0.36 6.21 0.32 1.55e-9 Alzheimer's disease (late onset); LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg19318889 chr4:1322082 MAEA -0.43 -7.25 -0.37 2.96e-12 Obesity-related traits; LUSC cis rs7927771 0.524 rs7118747 chr11:47889545 C/T cg20307385 chr11:47447363 PSMC3 -0.47 -7.02 -0.36 1.24e-11 Subjective well-being; LUSC cis rs9399137 0.507 rs7772031 chr6:135259734 G/A cg22676075 chr6:135203613 NA -0.64 -9.85 -0.47 2.84e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg22875332 chr1:76189707 ACADM 0.84 13.87 0.6 7.24e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs5985 0.583 rs7758057 chr6:6307578 C/G cg22185065 chr6:6318785 F13A1 -0.32 -6.53 -0.34 2.41e-10 End-stage coagulation; LUSC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg23172400 chr8:95962367 TP53INP1 -0.43 -8.96 -0.44 2.27e-17 Type 2 diabetes; LUSC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg09655341 chr17:79618100 PDE6G -0.27 -6.28 -0.33 1.03e-9 Eye color traits; LUSC cis rs6076065 0.723 rs2252824 chr20:23354748 C/T cg11657817 chr20:23433608 CST11 0.41 7.33 0.37 1.73e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.72 7.61 0.38 2.9e-13 Initial pursuit acceleration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23365699 chr2:197504454 CCDC150 0.44 6.17 0.32 1.97e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg19717773 chr7:2847554 GNA12 -0.39 -6.14 -0.32 2.29e-9 Height; LUSC cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 18.1 0.7 1.66e-51 Chronic sinus infection; LUSC cis rs1506636 0.708 rs7788702 chr7:123237421 C/T cg03229431 chr7:123269106 ASB15 0.62 9.38 0.46 1.02e-18 Plateletcrit;Platelet count; LUSC cis rs7178572 1.000 rs952471 chr15:77776498 C/G cg22256960 chr15:77711686 NA -0.55 -9.2 -0.45 4.07e-18 Type 2 diabetes; LUSC trans rs10435719 0.834 rs6985792 chr8:11795335 T/C cg27411982 chr8:10470053 RP1L1 0.39 6.03 0.31 4.29e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7759001 0.857 rs6923108 chr6:27362109 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs765787 0.530 rs4775837 chr15:45537684 G/T cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg11645453 chr3:52864694 ITIH4 0.31 7.19 0.37 4.16e-12 Bipolar disorder; LUSC cis rs9517320 0.534 rs3825430 chr13:99129653 C/T cg20487152 chr13:99095054 FARP1 -0.43 -7.2 -0.37 4.05e-12 Longevity; LUSC cis rs7572644 0.766 rs4578809 chr2:28082494 G/A cg27432699 chr2:27873401 GPN1 0.51 6.47 0.33 3.46e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg26597838 chr10:835615 NA 0.64 8.08 0.4 1.21e-14 Eosinophil percentage of granulocytes; LUSC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg00814883 chr7:100076585 TSC22D4 -0.67 -8.3 -0.41 2.54e-15 Platelet count; LUSC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg14343924 chr8:8086146 FLJ10661 -0.43 -6.04 -0.31 4.1e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs17385675 1.000 rs16838482 chr2:202814422 C/G cg01096478 chr12:50898751 DIP2B -0.76 -6.02 -0.31 4.5e-9 Response to antipsychotic treatment; LUSC cis rs4820539 1.000 rs885963 chr22:23460939 G/T cg14186256 chr22:23484241 RTDR1 0.95 17.83 0.7 1.95e-50 Bone mineral density; LUSC cis rs763121 0.962 rs1980455 chr22:38925719 A/C cg06544989 chr22:39130855 UNC84B 0.33 5.81 0.3 1.49e-8 Menopause (age at onset); LUSC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg03806693 chr22:41940476 POLR3H -0.87 -12.65 -0.57 3.07e-30 Vitiligo; LUSC cis rs6840360 0.571 rs11932059 chr4:152524496 G/A cg22705602 chr4:152727874 NA -0.32 -6.54 -0.34 2.28e-10 Intelligence (multi-trait analysis); LUSC cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg11584989 chr19:19387371 SF4 0.6 7.08 0.36 8.81e-12 Bipolar disorder; LUSC cis rs4919694 0.572 rs12261294 chr10:104934952 C/T cg04362960 chr10:104952993 NT5C2 0.91 11.51 0.53 4.9e-26 Arsenic metabolism; LUSC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -6.73 -0.35 7.36e-11 Total body bone mineral density; LUSC cis rs500891 0.525 rs2324416 chr6:84074210 A/G cg08257003 chr6:84140564 ME1 0.35 8.63 0.43 2.58e-16 Platelet-derived growth factor BB levels; LUSC cis rs9303280 0.870 rs1011082 chr17:38068514 T/C cg19468946 chr17:37922297 IKZF3 0.39 6.24 0.32 1.3e-9 Self-reported allergy; LUSC cis rs6960043 0.818 rs10258074 chr7:15064216 A/T cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC cis rs76878669 0.561 rs4930179 chr11:66157432 C/T cg18002602 chr11:66138449 SLC29A2 0.46 8.27 0.41 3.17e-15 Educational attainment (years of education); LUSC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg10909506 chr17:38081995 ORMDL3 0.34 6.07 0.32 3.55e-9 Self-reported allergy; LUSC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg05368731 chr17:41323189 NBR1 0.92 15.52 0.65 2.79e-41 Menopause (age at onset); LUSC cis rs6901250 0.632 rs1853080 chr6:117196157 T/C cg12892004 chr6:117198278 RFX6 -0.4 -7.76 -0.39 1.05e-13 C-reactive protein levels; LUSC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg06740227 chr12:86229804 RASSF9 -0.36 -5.7 -0.3 2.61e-8 Major depressive disorder; LUSC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg16060761 chr17:80687452 NA -0.52 -8.23 -0.41 4.16e-15 Glycated hemoglobin levels; LUSC cis rs950027 0.620 rs1145077 chr15:45683795 A/C cg26924012 chr15:45694286 SPATA5L1 -0.76 -12.25 -0.56 9.47e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs9473147 0.543 rs1004173 chr6:47445017 C/T cg02130027 chr6:47444894 CD2AP 0.35 5.66 0.3 3.33e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7843479 0.965 rs11785657 chr8:21859485 G/A cg17168535 chr8:21777572 XPO7 0.65 9.67 0.47 1.16e-19 Mean corpuscular volume; LUSC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11644478 chr21:40555479 PSMG1 0.8 14.58 0.62 1.32e-37 Cognitive function; LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03352830 chr11:487213 PTDSS2 0.78 9.42 0.46 7.77e-19 Body mass index; LUSC cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.51e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs2281845 0.965 rs3738263 chr1:201083506 A/G cg22815214 chr1:201083145 CACNA1S 0.58 10.25 0.49 1.25e-21 Permanent tooth development; LUSC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg18225595 chr11:63971243 STIP1 0.53 9.03 0.44 1.38e-17 Platelet count; LUSC trans rs1422110 0.513 rs1363264 chr5:85450380 G/C cg01787110 chr1:109008453 NBPF6 0.43 8.01 0.4 1.98e-14 Attention function in attention deficit hyperactive disorder; LUSC cis rs4629180 0.586 rs7583526 chr2:102124665 G/A cg04415270 chr2:102091202 RFX8 -0.44 -7.51 -0.38 5.38e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg08477640 chr19:41863820 B9D2 0.48 7.24 0.37 3.2e-12 Migraine;Coronary artery disease; LUSC cis rs12900413 0.687 rs13343250 chr15:90311410 T/C cg24249390 chr15:90295951 MESP1 -0.37 -5.91 -0.31 8.6e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg18681998 chr4:17616180 MED28 0.85 15.67 0.65 6.85e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs62400317 0.859 rs72870950 chr6:45154779 A/G cg18551225 chr6:44695536 NA -0.42 -6.87 -0.35 3.24e-11 Total body bone mineral density; LUSC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg16060761 chr17:80687452 NA 0.44 7.05 0.36 1.03e-11 Breast cancer; LUSC cis rs782590 0.967 rs62165172 chr2:55736237 A/G cg18811423 chr2:55921094 PNPT1 0.83 14.55 0.62 1.78e-37 Metabolic syndrome; LUSC cis rs7851660 0.809 rs1561961 chr9:100667599 C/T cg13688889 chr9:100608707 NA -0.54 -8.47 -0.42 7.71e-16 Strep throat; LUSC cis rs559928 0.606 rs1011219 chr11:63973396 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.72 -7.8 -0.39 8.18e-14 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs12681287 0.547 rs7465511 chr8:87521481 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.27 -0.37 2.64e-12 Caudate activity during reward; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18737971 chr15:43941642 CATSPER2 0.43 6.48 0.33 3.31e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs243505 0.861 rs243525 chr7:148418140 G/A cg09806900 chr7:148480153 CUL1 -0.47 -6.69 -0.34 9.69e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs28830936 0.966 rs62002090 chr15:42092326 C/T cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.96 -0.31 6.55e-9 Diastolic blood pressure; LUSC cis rs4780401 0.609 rs12927966 chr16:11814562 C/T cg01061890 chr16:11836724 TXNDC11 -0.56 -8.61 -0.43 2.92e-16 Rheumatoid arthritis; LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.23 0.37 3.42e-12 Bipolar disorder; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg27284194 chr4:1044797 NA -0.35 -5.83 -0.3 1.29e-8 Longevity; LUSC trans rs7786808 0.653 rs7810861 chr7:158212633 G/A cg02030672 chr11:45687055 CHST1 0.44 7.05 0.36 1.03e-11 Obesity-related traits; LUSC cis rs2455601 0.638 rs2742485 chr11:8986787 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.23 -0.32 1.44e-9 Schizophrenia; LUSC cis rs3008870 0.959 rs1886686 chr1:67390468 C/G cg08660285 chr1:67390436 MIER1;WDR78 0.94 14.91 0.63 6.66e-39 Lymphocyte percentage of white cells; LUSC cis rs61990749 0.597 rs176955 chr14:78181220 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.46 0.33 3.77e-10 Fibroblast growth factor basic levels; LUSC cis rs10484885 0.887 rs17764308 chr6:90602268 T/C cg13799429 chr6:90582589 CASP8AP2 -0.79 -8.48 -0.42 7.58e-16 QRS interval (sulfonylurea treatment interaction); LUSC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg11764359 chr7:65958608 NA 0.81 13.62 0.6 6.4e-34 Aortic root size; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10130314 chr10:71993273 PPA1 -0.52 -6.32 -0.33 8.56e-10 Bipolar disorder and schizophrenia; LUSC cis rs62400317 0.859 rs10948211 chr6:45156767 G/A cg18551225 chr6:44695536 NA -0.44 -7.18 -0.37 4.62e-12 Total body bone mineral density; LUSC cis rs2625529 0.526 rs8031386 chr15:72508799 C/A cg16672083 chr15:72433130 SENP8 -0.48 -7.55 -0.38 4.23e-13 Red blood cell count; LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg16479474 chr6:28041457 NA 0.34 5.89 0.31 9.45e-9 Parkinson's disease; LUSC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.77 0.39 9.65e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs924607 0.900 rs1697950 chr5:616890 G/A cg09021430 chr5:549028 NA 0.43 7.59 0.38 3.16e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs17604090 0.818 rs28390296 chr7:29687091 C/T cg19413766 chr7:29689036 LOC646762 -0.58 -6.93 -0.35 2.12e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13012494 chr21:47604986 C21orf56 -0.47 -7.05 -0.36 1.03e-11 Testicular germ cell tumor; LUSC cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg25427524 chr10:38739819 LOC399744 -0.63 -11.27 -0.52 3.58e-25 Extrinsic epigenetic age acceleration; LUSC trans rs28735056 0.508 rs67651675 chr18:77673562 A/G cg05926928 chr17:57297772 GDPD1 -0.58 -8.47 -0.42 7.7e-16 Schizophrenia; LUSC cis rs17826219 0.706 rs8071236 chr17:29100002 T/C cg13385521 chr17:29058706 SUZ12P 0.69 6.79 0.35 5.27e-11 Body mass index; LUSC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg04871131 chr7:94954202 PON1 -0.38 -6.03 -0.31 4.43e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6960043 0.782 rs1558317 chr7:15065564 T/A cg19272540 chr7:15055459 NA -0.28 -6.84 -0.35 3.8e-11 Type 2 diabetes; LUSC cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg24692254 chr21:30365293 RNF160 0.83 15.25 0.64 3.13e-40 Dental caries; LUSC cis rs1371867 0.846 rs2047249 chr8:101234126 A/G cg06002616 chr8:101225028 SPAG1 0.41 6.45 0.33 3.95e-10 Atrioventricular conduction; LUSC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.56e-11 Total body bone mineral density; LUSC cis rs500891 0.525 rs2023241 chr6:84051460 G/A cg08257003 chr6:84140564 ME1 0.33 7.98 0.4 2.44e-14 Platelet-derived growth factor BB levels; LUSC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg10792982 chr14:105748885 BRF1 0.52 9.22 0.45 3.53e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg23093090 chr10:104574429 C10orf26 -0.46 -8.24 -0.41 3.87e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2067615 0.579 rs3782709 chr12:107205753 A/G cg15890332 chr12:107067104 RFX4 0.33 5.94 0.31 7.24e-9 Heart rate; LUSC cis rs4629710 0.545 rs11755717 chr6:131547028 A/T cg12606694 chr6:131520996 AKAP7 -0.51 -7.62 -0.38 2.68e-13 Multiple myeloma (IgH translocation); LUSC trans rs17685 0.753 rs10233282 chr7:75790081 C/T cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs8141797 0.901 rs6004051 chr22:24462072 A/C cg00411358 chr22:24577142 SUSD2 0.62 6.08 0.32 3.31e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC trans rs61931739 0.534 rs1608911 chr12:34010249 T/C cg13010199 chr12:38710504 ALG10B 0.55 8.27 0.41 3.16e-15 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.66 10.5 0.5 1.73e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7209700 0.574 rs3851806 chr17:45350919 G/C cg18085866 chr17:45331354 ITGB3 -0.54 -5.82 -0.3 1.36e-8 IgG glycosylation; LUSC cis rs7647973 0.925 rs6808036 chr3:49236439 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.47 6.97 0.36 1.69e-11 Menarche (age at onset); LUSC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg12463550 chr7:65579703 CRCP -0.56 -8.3 -0.41 2.67e-15 Aortic root size; LUSC cis rs2836633 0.929 rs11701577 chr21:40028906 C/T cg12884169 chr21:40033163 ERG 0.61 12.36 0.56 3.74e-29 Coronary artery disease; LUSC cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg21573476 chr21:45109991 RRP1B -0.46 -7.26 -0.37 2.77e-12 Mean corpuscular volume; LUSC cis rs6469656 0.892 rs7013617 chr8:117746231 G/A cg24004040 chr8:117650383 NA -0.43 -6.23 -0.32 1.4e-9 Colorectal cancer; LUSC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.63 0.34 1.34e-10 Lung cancer; LUSC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg18131467 chr2:239335373 ASB1 1.04 25.38 0.81 6.46e-80 Multiple system atrophy; LUSC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg09165964 chr15:75287851 SCAMP5 0.51 7.5 0.38 5.66e-13 Breast cancer; LUSC cis rs6733011 0.578 rs1581251 chr2:99500867 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.79 -0.3 1.67e-8 Bipolar disorder; LUSC cis rs977987 0.843 rs59465235 chr16:75483810 C/G cg04384234 chr16:75411784 CFDP1 -0.44 -7.35 -0.37 1.49e-12 Dupuytren's disease; LUSC trans rs1493916 0.748 rs1941684 chr18:31304421 C/G cg27147174 chr7:100797783 AP1S1 -0.57 -9.07 -0.44 1.01e-17 Life satisfaction; LUSC cis rs1790761 0.667 rs591434 chr11:67337814 C/T cg00864171 chr11:67383662 NA 0.35 6.14 0.32 2.31e-9 Mean corpuscular volume; LUSC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs6500395 0.962 rs9923371 chr16:48628015 C/T cg04672837 chr16:48644449 N4BP1 0.49 7.31 0.37 1.95e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg01973587 chr1:228161476 NA 0.45 8.11 0.41 9.98e-15 Diastolic blood pressure; LUSC cis rs951366 0.576 rs11240561 chr1:205712957 T/G cg07157834 chr1:205819609 PM20D1 -0.44 -5.87 -0.31 1.03e-8 Menarche (age at onset); LUSC cis rs2729354 0.903 rs2729371 chr11:57321322 A/G cg24343310 chr11:57249947 NA 0.33 5.97 0.31 6.15e-9 Blood protein levels; LUSC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.19e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs7819412 0.540 rs2409725 chr8:11041661 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.12 -0.36 6.69e-12 Triglycerides; LUSC cis rs9486715 0.867 rs9486181 chr6:96868132 G/A cg06623918 chr6:96969491 KIAA0776 0.93 17.56 0.69 2.32e-49 Headache; LUSC cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg22455342 chr2:225449267 CUL3 0.75 10.34 0.49 6.37e-22 IgE levels in asthmatics (D.p. specific); LUSC cis rs80282103 0.571 rs56183119 chr10:1068370 C/T cg18964960 chr10:1102726 WDR37 0.62 6.02 0.31 4.72e-9 Glomerular filtration rate (creatinine); LUSC cis rs17685 0.884 rs6978677 chr7:75636240 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.45 -6.75 -0.35 6.68e-11 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7953249 0.618 rs7954331 chr12:121398657 G/T cg02403541 chr12:121454288 C12orf43 -0.72 -11.01 -0.52 2.86e-24 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs9325144 0.647 rs34311455 chr12:39060889 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.57 -0.46 2.55e-19 Morning vs. evening chronotype; LUSC cis rs71636778 0.543 rs12749822 chr1:27221963 T/C cg12203394 chr1:27248618 NUDC 0.54 5.71 0.3 2.52e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.62 0.47 1.72e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs1801251 0.752 rs2592126 chr2:233751377 A/G cg25237894 chr2:233734115 C2orf82 -0.36 -6.83 -0.35 4.03e-11 Coronary artery disease; LUSC cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg08999081 chr20:33150536 PIGU 0.38 6.93 0.35 2.15e-11 Height; LUSC cis rs11098499 0.913 rs68128210 chr4:120137819 T/G cg24375607 chr4:120327624 NA 0.71 10.61 0.5 7.32e-23 Corneal astigmatism; LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg05165339 chr4:1420672 NA -0.31 -6.96 -0.36 1.84e-11 Longevity; LUSC cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs13089785 0.965 rs67028142 chr3:123635213 A/G cg02558132 chr3:123411198 MYLK 0.35 5.95 0.31 6.61e-9 Intelligence (multi-trait analysis); LUSC cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg16346588 chr10:242978 ZMYND11 0.43 6.19 0.32 1.76e-9 Psychosis in Alzheimer's disease; LUSC cis rs3020736 0.500 rs764481 chr22:42518426 G/A cg05082376 chr22:42548792 NA 0.44 6.6 0.34 1.57e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg10295955 chr4:187884368 NA -1.07 -24.0 -0.8 1.07e-74 Lobe attachment (rater-scored or self-reported); LUSC cis rs453301 0.506 rs476845 chr8:8622877 A/G cg08975724 chr8:8085496 FLJ10661 -0.45 -6.26 -0.32 1.16e-9 Joint mobility (Beighton score); LUSC cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.53 -7.96 -0.4 2.68e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11650494 0.710 rs11651666 chr17:47474571 C/T cg08112188 chr17:47440006 ZNF652 1.07 8.88 0.44 4.3e-17 Prostate cancer; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27582017 chr1:1057683 NA 0.38 6.19 0.32 1.73e-9 Asthma; LUSC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg07936489 chr17:37558343 FBXL20 0.71 9.71 0.47 8.7e-20 Glomerular filtration rate (creatinine); LUSC trans rs1493916 0.967 rs1389532 chr18:31392323 C/T cg27147174 chr7:100797783 AP1S1 -0.65 -10.41 -0.49 3.75e-22 Life satisfaction; LUSC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg05855489 chr10:104503620 C10orf26 0.59 9.54 0.46 3.05e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg09033563 chr22:24373618 LOC391322 -0.69 -10.61 -0.5 7.48e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs2790216 0.526 rs1199093 chr10:59896794 C/G cg05008406 chr3:118959563 B4GALT4 -0.38 -6.04 -0.31 4.05e-9 Inflammatory bowel disease; LUSC cis rs7829975 0.606 rs11776838 chr8:8794801 C/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.91 -0.35 2.51e-11 Mood instability; LUSC cis rs2404602 0.692 rs2137307 chr15:77149020 T/A cg23625390 chr15:77176239 SCAPER 0.47 7.06 0.36 9.67e-12 Blood metabolite levels; LUSC trans rs208520 0.690 rs3899423 chr6:66835285 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -16.64 -0.67 1.03e-45 Exhaled nitric oxide output; LUSC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.86 0.47 2.61e-20 Major depressive disorder; LUSC cis rs763121 0.853 rs5750626 chr22:38977890 G/C cg06022373 chr22:39101656 GTPBP1 0.78 12.14 0.55 2.33e-28 Menopause (age at onset); LUSC trans rs61931739 0.817 rs11053071 chr12:34201400 A/G cg26384229 chr12:38710491 ALG10B 0.55 9.03 0.44 1.41e-17 Morning vs. evening chronotype; LUSC cis rs7914558 0.646 rs7909286 chr10:104658992 A/G cg05855489 chr10:104503620 C10orf26 0.42 5.76 0.3 1.92e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.73 0.51 2.9e-23 Bladder cancer; LUSC trans rs10109025 0.670 rs7825690 chr8:10858257 G/T cg15556689 chr8:8085844 FLJ10661 -0.42 -6.1 -0.32 2.94e-9 Joint mobility (Beighton score); LUSC trans rs2243480 1.000 rs34192067 chr7:65887657 C/A cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC cis rs9393777 0.623 rs9358948 chr6:26483806 G/A cg12292205 chr6:26970375 C6orf41 -0.63 -7.57 -0.38 3.72e-13 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.701 rs9627280 chr22:46643964 T/C cg09491104 chr22:46646882 C22orf40 -0.59 -8.51 -0.42 6.12e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.04 15.66 0.65 8.17e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs11030122 0.632 rs714380 chr11:4059653 A/T cg08557956 chr11:4115526 RRM1 -0.5 -6.37 -0.33 6.13e-10 Mean platelet volume;Platelet distribution width; LUSC cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg13010199 chr12:38710504 ALG10B 0.69 10.56 0.5 1.13e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg14552801 chr7:65878734 NA 0.38 5.76 0.3 1.96e-8 Aortic root size; LUSC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg25566285 chr7:158114605 PTPRN2 0.33 6.16 0.32 2.14e-9 Calcium levels; LUSC cis rs11039100 0.599 rs34123108 chr11:5834724 A/G cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2274273 0.686 rs2296489 chr14:55624977 T/C cg04306507 chr14:55594613 LGALS3 0.48 9.62 0.47 1.68e-19 Protein biomarker; LUSC cis rs2742234 0.590 rs2075912 chr10:43622217 T/C cg02780029 chr10:43622663 RET -0.33 -5.67 -0.3 3.01e-8 Hirschsprung disease; LUSC cis rs1728785 1.000 rs698719 chr16:68560125 C/T cg02972257 chr16:68554789 NA -0.48 -6.19 -0.32 1.76e-9 Ulcerative colitis; LUSC cis rs1185460 0.967 rs11217137 chr11:118931030 A/G cg01677386 chr11:118938358 VPS11 -0.51 -7.03 -0.36 1.18e-11 Coronary artery disease; LUSC cis rs7677751 0.806 rs4864858 chr4:55089953 T/A cg17187183 chr4:55093834 PDGFRA 0.38 5.83 0.3 1.3e-8 Corneal astigmatism; LUSC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg06221963 chr1:154839813 KCNN3 -0.61 -13.83 -0.6 1.03e-34 Prostate cancer; LUSC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg18758796 chr5:131593413 PDLIM4 0.4 7.06 0.36 9.75e-12 Blood metabolite levels; LUSC cis rs1371867 0.846 rs1660338 chr8:101242757 C/G cg00191853 chr8:101177733 SPAG1 -0.37 -6.15 -0.32 2.2e-9 Atrioventricular conduction; LUSC cis rs1577917 0.958 rs1545376 chr6:86504582 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.6 8.78 0.43 8.59e-17 Response to antipsychotic treatment; LUSC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg10523679 chr1:76189770 ACADM -0.83 -11.37 -0.53 1.48e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2295359 0.892 rs11209005 chr1:67618678 A/G cg03340356 chr1:67600835 NA 0.43 6.78 0.35 5.46e-11 Psoriasis; LUSC cis rs1983891 0.955 rs7753653 chr6:41548430 C/T cg20194872 chr6:41519635 FOXP4 -0.34 -6.15 -0.32 2.18e-9 Prostate cancer; LUSC cis rs9612 0.718 rs346532 chr19:44248878 A/G cg08581076 chr19:44259116 C19orf61 0.51 6.38 0.33 5.94e-10 Exhaled nitric oxide output; LUSC cis rs1009647 0.645 rs117502961 chr14:55599914 T/G cg04306507 chr14:55594613 LGALS3 0.45 6.26 0.32 1.21e-9 Testicular germ cell tumor; LUSC cis rs7246967 0.673 rs7247191 chr19:22899585 C/T cg23217946 chr19:22817039 ZNF492 0.41 5.68 0.3 2.93e-8 Bronchopulmonary dysplasia; LUSC cis rs11608355 0.515 rs56244055 chr12:109936211 G/A cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC trans rs7726839 0.526 rs11960158 chr5:568665 C/T cg11887960 chr12:57824829 NA 0.48 6.67 0.34 1.04e-10 Obesity-related traits; LUSC cis rs6964587 0.610 rs2888850 chr7:91430027 T/C cg17063962 chr7:91808500 NA 0.54 8.76 0.43 1.01e-16 Breast cancer; LUSC cis rs1190596 0.525 rs7153005 chr14:102698599 G/T cg18135206 chr14:102964638 TECPR2 -0.47 -6.02 -0.31 4.48e-9 Behavioural disinhibition (generation interaction); LUSC cis rs4073416 0.535 rs7150448 chr14:65871502 C/T cg03016385 chr14:66212404 NA -0.38 -5.8 -0.3 1.5e-8 N-glycan levels; LUSC cis rs6594499 0.872 rs13178997 chr5:110444249 G/T cg04022379 chr5:110408740 TSLP 0.45 6.78 0.35 5.56e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7945718 0.805 rs11022510 chr11:12833262 G/A cg25843174 chr11:12811716 TEAD1 0.31 7.24 0.37 3.17e-12 Educational attainment (years of education); LUSC cis rs11677370 0.603 rs10178523 chr2:3854169 G/A cg17052675 chr2:3827356 NA -0.63 -10.1 -0.48 4.21e-21 Type 2 diabetes; LUSC cis rs7829975 0.811 rs7011229 chr8:8543324 T/C cg08975724 chr8:8085496 FLJ10661 -0.45 -6.67 -0.34 1.06e-10 Mood instability; LUSC cis rs11155671 0.530 rs9383577 chr6:150207195 C/T cg07701084 chr6:150067640 NUP43 0.47 7.03 0.36 1.15e-11 Testicular germ cell tumor; LUSC cis rs12208915 0.559 rs4706738 chr6:79514153 A/G cg05283184 chr6:79620031 NA 0.43 7.95 0.4 2.87e-14 Left atrial antero-posterior diameter; LUSC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg07701084 chr6:150067640 NUP43 0.58 9.11 0.45 7.91e-18 Lung cancer; LUSC trans rs9650657 0.506 rs7823296 chr8:10778546 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.19 -0.37 4.4e-12 Neuroticism; LUSC cis rs96067 0.805 rs6425966 chr1:36611287 C/T cg24686825 chr1:36642396 MAP7D1 0.68 9.56 0.46 2.59e-19 Corneal structure; LUSC cis rs354225 0.544 rs11902987 chr2:54805587 C/T cg26097391 chr2:54893211 SPTBN1 0.46 6.99 0.36 1.55e-11 Schizophrenia; LUSC cis rs7106204 0.514 rs2083753 chr11:24255896 A/G ch.11.24196551F chr11:24239977 NA 0.91 10.22 0.49 1.7e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.43e-16 Menopause (age at onset); LUSC cis rs11190604 1.000 rs7084810 chr10:102297546 A/G cg07080220 chr10:102295463 HIF1AN 0.69 9.38 0.46 1.06e-18 Palmitoleic acid (16:1n-7) levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18728699 chr15:90931313 IQGAP1 0.47 6.27 0.32 1.11e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs9354352 1.000 rs9354352 chr6:66696272 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.64 9.19 0.45 4.34e-18 Initial pursuit acceleration in psychotic disorders; LUSC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg12463550 chr7:65579703 CRCP 0.5 6.99 0.36 1.46e-11 Aortic root size; LUSC cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1568889 1.000 rs61236373 chr11:28212720 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.3 0.45 1.95e-18 Bipolar disorder; LUSC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg24110177 chr3:50126178 RBM5 0.57 9.24 0.45 3e-18 Intelligence (multi-trait analysis); LUSC cis rs6693567 0.516 rs7554686 chr1:150265619 A/T cg15654264 chr1:150340011 RPRD2 -0.45 -7.25 -0.37 2.9e-12 Migraine; LUSC cis rs483180 0.531 rs539708 chr1:120208503 G/T cg19096424 chr1:120255104 PHGDH -0.47 -6.62 -0.34 1.41e-10 Macular telangiectasia type 2; LUSC cis rs71403859 0.730 rs17356316 chr16:71746921 C/T cg08717414 chr16:71523259 ZNF19 -0.66 -7.29 -0.37 2.2e-12 Post bronchodilator FEV1; LUSC cis rs17539620 0.624 rs62432736 chr6:154834401 A/G cg20019720 chr6:154832845 CNKSR3 0.64 8.73 0.43 1.22e-16 Lipoprotein (a) levels; LUSC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.66e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4820539 0.966 rs2157709 chr22:23457420 T/C cg21100191 chr22:23484243 RTDR1 0.91 15.5 0.65 3.21e-41 Bone mineral density; LUSC cis rs8078723 1.000 rs3213762 chr17:38178627 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.9 -0.35 2.69e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs854765 0.655 rs4470201 chr17:17844870 G/A cg09796270 chr17:17721594 SREBF1 0.42 7.51 0.38 5.43e-13 Total body bone mineral density; LUSC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg13902645 chr11:5959945 NA -0.57 -8.07 -0.4 1.3e-14 DNA methylation (variation); LUSC cis rs6681460 1.000 rs7521111 chr1:67121634 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.99 0.44 1.94e-17 Presence of antiphospholipid antibodies; LUSC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg05863683 chr7:1912471 MAD1L1 -0.3 -5.8 -0.3 1.52e-8 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.806 rs6564252 chr16:75388940 C/T cg04384234 chr16:75411784 CFDP1 -0.39 -6.22 -0.32 1.46e-9 Dupuytren's disease; LUSC trans rs10885582 0.839 rs11196794 chr10:116349314 A/G cg01002288 chr1:43166549 YBX1 -0.36 -6.07 -0.32 3.5e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -6.19 -0.32 1.78e-9 Crohn's disease; LUSC cis rs977987 0.815 rs11646677 chr16:75408981 T/C cg03315344 chr16:75512273 CHST6 0.53 10.42 0.5 3.39e-22 Dupuytren's disease; LUSC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg24733560 chr20:60626293 TAF4 0.43 7.82 0.39 6.95e-14 Body mass index; LUSC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg22834771 chr12:69754056 YEATS4 -0.43 -5.89 -0.31 9.32e-9 Cerebrospinal fluid biomarker levels; LUSC cis rs617219 0.671 rs2607144 chr5:78556798 G/T cg24856658 chr5:78533917 JMY -0.29 -5.91 -0.31 8.46e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs4363385 0.818 rs436621 chr1:153005492 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.45e-8 Inflammatory skin disease; LUSC cis rs477692 0.699 rs471357 chr10:131389373 C/G cg26102564 chr10:131424627 MGMT 0.4 6.1 0.32 2.94e-9 Response to temozolomide; LUSC cis rs6961069 0.745 rs3212160 chr7:80273308 A/C cg04458919 chr7:80252533 CD36 0.34 6.15 0.32 2.26e-9 Platelet count; LUSC cis rs1594829 0.500 rs2046223 chr8:26210178 C/T cg13160058 chr8:26243215 BNIP3L 0.32 5.74 0.3 2.08e-8 Height; LUSC cis rs1882538 0.596 rs10281827 chr7:133081810 A/G cg10665199 chr7:133106180 EXOC4 0.58 8.04 0.4 1.53e-14 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg18512352 chr11:47633146 NA 0.46 9.21 0.45 3.61e-18 Subjective well-being; LUSC cis rs10992471 0.603 rs7873397 chr9:95205928 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.72 -0.39 1.34e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg06238570 chr21:40685208 BRWD1 0.48 7.24 0.37 3.06e-12 Cognitive function; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg00358695 chr19:42463363 RABAC1 0.39 5.97 0.31 6.21e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7524258 0.868 rs2157499 chr1:7271472 C/T cg07173049 chr1:7289937 CAMTA1 0.31 6.4 0.33 5.27e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs3820068 0.705 rs4645983 chr1:15850603 G/A cg17385448 chr1:15911702 AGMAT 0.36 5.86 0.31 1.12e-8 Systolic blood pressure; LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg00838250 chr3:186287958 TBCCD1;DNAJB11 -0.34 -6.15 -0.32 2.22e-9 Breast cancer; LUSC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.91 -0.4 3.82e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs10193935 0.792 rs6735571 chr2:42491951 C/T cg27598129 chr2:42591480 NA -0.58 -7.98 -0.4 2.35e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg00701064 chr4:6280414 WFS1 0.57 13.7 0.6 3.15e-34 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs10090774 0.687 rs11774679 chr8:141917656 A/T cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 5.99 0.31 5.42e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs66569888 0.789 rs17213078 chr2:106734065 G/A cg15412446 chr2:106886593 NA -0.5 -6.22 -0.32 1.47e-9 Facial morphology (factor 23); LUSC cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.34 0.46 1.39e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.29 0.37 2.3e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs10802346 0.514 rs5024440 chr1:246372608 G/C cg22732515 chr19:44031385 ETHE1 0.62 10.29 0.49 9.12e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg25251562 chr2:3704773 ALLC -0.36 -6.26 -0.32 1.17e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs11148252 0.508 rs6561671 chr13:53182314 G/A cg18335740 chr13:41363409 SLC25A15 0.75 13.62 0.6 6.9e-34 Lewy body disease; LUSC cis rs11785693 0.862 rs10503292 chr8:4992275 A/G cg26367366 chr8:4980734 NA 0.6 7.05 0.36 1.02e-11 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs2932538 0.961 rs6537747 chr1:113179597 C/T cg22162597 chr1:113214053 CAPZA1 -0.52 -7.51 -0.38 5.52e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg13390004 chr1:15929781 NA 0.42 7.04 0.36 1.07e-11 Systolic blood pressure; LUSC cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.5 8.1 0.41 1.05e-14 IgG glycosylation; LUSC cis rs5769707 0.681 rs4622843 chr22:50036916 T/G cg05373962 chr22:49881684 NA -0.39 -8.55 -0.42 4.37e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6840360 0.571 rs62327270 chr4:152533618 C/T cg22705602 chr4:152727874 NA -0.32 -6.53 -0.34 2.44e-10 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.538 rs7755996 chr6:86423720 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.42 6.65 0.34 1.2e-10 Response to antipsychotic treatment; LUSC cis rs4555082 1.000 rs7149013 chr14:105759840 T/C cg13114125 chr14:105738426 BRF1 -0.89 -14.18 -0.61 4.61e-36 Mean platelet volume;Platelet distribution width; LUSC cis rs859767 0.741 rs1516991 chr2:135370052 G/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.42 -0.33 4.7e-10 Neuroticism; LUSC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg02269571 chr22:50332266 NA -0.57 -8.59 -0.43 3.41e-16 Schizophrenia; LUSC cis rs9677476 0.779 rs12612219 chr2:232107363 G/T cg07929768 chr2:232055508 NA 0.36 6.18 0.32 1.83e-9 Food antigen IgG levels; LUSC cis rs12681287 0.547 rs9942792 chr8:87509046 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg09650180 chr20:62225654 GMEB2 -0.66 -9.69 -0.47 1.03e-19 Glioblastoma; LUSC cis rs868036 1.000 rs4633663 chr15:68106378 G/C cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs17092148 1.000 rs62211617 chr20:33400355 C/G cg16810054 chr20:33298113 TP53INP2 0.45 6.77 0.35 5.85e-11 Neuroticism; LUSC cis rs3849570 0.643 rs6797240 chr3:81971856 T/C cg07356753 chr3:81810745 GBE1 -0.49 -7.22 -0.37 3.44e-12 Waist circumference;Body mass index; LUSC cis rs6840360 0.615 rs1877188 chr4:152607931 T/C cg22705602 chr4:152727874 NA -0.37 -7.97 -0.4 2.61e-14 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg00310523 chr12:86230176 RASSF9 0.43 7.66 0.39 2.07e-13 Major depressive disorder; LUSC cis rs1113500 0.897 rs11185263 chr1:108639804 C/G cg11967332 chr1:108735228 SLC25A24 0.38 5.71 0.3 2.45e-8 Growth-regulated protein alpha levels; LUSC cis rs7572644 0.699 rs6731650 chr2:28261163 C/A cg27432699 chr2:27873401 GPN1 -0.52 -7.07 -0.36 9.22e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11890956 chr21:40555474 PSMG1 -0.88 -15.45 -0.65 5.46e-41 Cognitive function; LUSC cis rs12477438 0.765 rs2278895 chr2:99613484 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.75 -0.51 2.45e-23 Chronic sinus infection; LUSC trans rs2204008 0.604 rs11172718 chr12:38069819 T/C cg06521331 chr12:34319734 NA -0.41 -6.45 -0.33 3.95e-10 Bladder cancer; LUSC trans rs6951245 1.000 rs78143408 chr7:1096846 G/A cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2439831 1.000 rs537115 chr15:43729948 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.33 0.41 2.06e-15 Lung cancer in ever smokers; LUSC cis rs11626933 0.851 rs2282031 chr14:90730943 A/G cg14092571 chr14:90743983 NA -0.76 -15.2 -0.64 5.12e-40 Gut microbiota (bacterial taxa); LUSC cis rs1153858 1.000 rs1145074 chr15:45703824 T/A cg21132104 chr15:45694354 SPATA5L1 0.55 7.54 0.38 4.48e-13 Homoarginine levels; LUSC cis rs1215050 0.765 rs588851 chr4:98678247 C/T cg05340658 chr4:99064831 C4orf37 0.46 7.28 0.37 2.39e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg24562669 chr7:97807699 LMTK2 0.34 6.01 0.31 4.73e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs3857536 0.813 rs1891599 chr6:66941699 A/G cg07460842 chr6:66804631 NA -0.46 -6.35 -0.33 6.98e-10 Blood trace element (Cu levels); LUSC cis rs7833986 0.501 rs2719226 chr8:57044066 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.73 11.92 0.55 1.56e-27 Height; LUSC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs9653442 1.000 rs9653442 chr2:100825367 A/G cg22139774 chr2:100720529 AFF3 0.42 7.54 0.38 4.52e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1153858 0.723 rs11855527 chr15:45606685 G/A cg21132104 chr15:45694354 SPATA5L1 -0.52 -6.89 -0.35 2.76e-11 Homoarginine levels; LUSC cis rs4969178 0.965 rs12451791 chr17:76397343 G/A cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg00684032 chr4:1343700 KIAA1530 0.34 6.13 0.32 2.5e-9 Obesity-related traits; LUSC cis rs751728 0.648 rs6922275 chr6:33749739 G/A cg25922239 chr6:33757077 LEMD2 0.42 6.28 0.33 1.05e-9 Crohn's disease; LUSC cis rs7267979 0.932 rs6115214 chr20:25557426 C/T cg08601574 chr20:25228251 PYGB -0.4 -5.99 -0.31 5.42e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg02221750 chr19:17393354 ANKLE1 -0.92 -14.18 -0.61 4.48e-36 Systemic lupus erythematosus; LUSC cis rs2806561 0.695 rs66592286 chr1:23333649 G/C cg12483005 chr1:23474871 LUZP1 0.41 6.09 0.32 3.12e-9 Height; LUSC cis rs17824933 0.848 rs11230559 chr11:60769534 T/C cg16817237 chr11:60793675 NA 0.4 6.34 0.33 7.24e-10 Multiple sclerosis; LUSC cis rs73206853 0.841 rs73206845 chr12:110660556 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 6.45 0.33 3.99e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs17270561 0.609 rs1937131 chr6:25744831 A/T cg17691542 chr6:26056736 HIST1H1C -0.5 -7.09 -0.36 8.28e-12 Iron status biomarkers; LUSC cis rs6500602 0.702 rs11076835 chr16:4549618 G/A cg08645402 chr16:4508243 NA 0.51 8.64 0.43 2.29e-16 Schizophrenia; LUSC cis rs1023500 0.596 rs133352 chr22:42434022 C/A cg04733989 chr22:42467013 NAGA 0.62 9.64 0.47 1.5e-19 Schizophrenia; LUSC cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg04450456 chr4:17643702 FAM184B -0.35 -6.0 -0.31 5.13e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg15744005 chr10:104629667 AS3MT -0.29 -6.27 -0.32 1.13e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg05283184 chr6:79620031 NA -0.57 -11.83 -0.54 3.38e-27 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.704 rs138837 chr22:50180714 A/G cg02269571 chr22:50332266 NA -0.45 -6.96 -0.36 1.78e-11 Schizophrenia; LUSC cis rs11648785 0.735 rs868372 chr16:90097995 C/G cg16611967 chr16:90144006 NA 0.44 5.84 0.3 1.23e-8 Tanning; LUSC cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg21573476 chr21:45109991 RRP1B -0.38 -5.92 -0.31 7.85e-9 Mean corpuscular volume; LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg07677032 chr17:61819896 STRADA 0.54 8.95 0.44 2.52e-17 Prudent dietary pattern; LUSC cis rs1215050 0.791 rs783959 chr4:98893476 C/T cg05340658 chr4:99064831 C4orf37 -0.45 -7.14 -0.36 5.83e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg27494647 chr7:150038898 RARRES2 0.53 8.12 0.41 9.22e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs7647973 0.626 rs9829155 chr3:49817450 T/C cg03060546 chr3:49711283 APEH -0.62 -7.37 -0.37 1.37e-12 Menarche (age at onset); LUSC cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg24812749 chr6:127587940 RNF146 0.92 13.73 0.6 2.61e-34 Breast cancer; LUSC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg03452623 chr4:187889614 NA -0.88 -17.59 -0.69 1.82e-49 Lobe attachment (rater-scored or self-reported); LUSC trans rs1728785 0.892 rs4783648 chr16:68558334 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.56 -6.74 -0.35 7.16e-11 Ulcerative colitis; LUSC cis rs2625529 0.824 rs16956328 chr15:72143855 A/T cg16672083 chr15:72433130 SENP8 -0.51 -7.5 -0.38 5.83e-13 Red blood cell count; LUSC cis rs12286929 0.617 rs11607928 chr11:115102224 A/G cg04055981 chr11:115044050 NA 0.35 6.21 0.32 1.6e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.606 rs4699606 chr4:99095074 A/C cg05340658 chr4:99064831 C4orf37 -0.5 -7.64 -0.39 2.32e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.56 7.59 0.38 3.22e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg19318889 chr4:1322082 MAEA 0.46 7.53 0.38 4.92e-13 Longevity; LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg08088566 chr11:430123 ANO9 0.64 7.47 0.38 7.09e-13 Body mass index; LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.77 0.39 9.79e-14 Prudent dietary pattern; LUSC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg03676636 chr4:99064102 C4orf37 0.37 7.95 0.4 2.83e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg20476274 chr7:133979776 SLC35B4 0.79 13.49 0.59 2.12e-33 Mean platelet volume; LUSC cis rs9311676 0.656 rs3191903 chr3:58382846 C/T cg26110898 chr3:58419937 PDHB 0.4 6.45 0.33 3.95e-10 Systemic lupus erythematosus; LUSC cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg23711669 chr6:146136114 FBXO30 0.87 16.39 0.67 1.03e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg05165339 chr4:1420672 NA -0.3 -6.58 -0.34 1.78e-10 Longevity; LUSC cis rs10504073 0.584 rs11786103 chr8:49904077 A/G cg00325661 chr8:49890786 NA 0.69 11.04 0.52 2.29e-24 Blood metabolite ratios; LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg20887711 chr4:1340912 KIAA1530 0.4 5.79 0.3 1.62e-8 Obesity-related traits; LUSC cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg05868516 chr6:26286170 HIST1H4H 0.37 6.09 0.32 3.03e-9 Educational attainment; LUSC cis rs7666738 0.546 rs34159897 chr4:98787367 T/C cg17366294 chr4:99064904 C4orf37 0.55 8.77 0.43 9.47e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs62400317 0.859 rs6919998 chr6:45159289 C/T cg18551225 chr6:44695536 NA -0.44 -7.2 -0.37 4.1e-12 Total body bone mineral density; LUSC cis rs2463822 0.925 rs74692811 chr11:62156572 G/A cg06239285 chr11:62104954 ASRGL1 -0.98 -10.97 -0.51 4.05e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg11494091 chr17:61959527 GH2 0.63 13.54 0.6 1.31e-33 Prudent dietary pattern; LUSC cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg13319975 chr6:146136371 FBXO30 -0.53 -7.93 -0.4 3.44e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.836 rs7484454 chr12:86425576 A/G cg02569458 chr12:86230093 RASSF9 0.38 6.07 0.32 3.39e-9 Major depressive disorder; LUSC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg09034736 chr1:150693464 HORMAD1 0.45 6.43 0.33 4.36e-10 Melanoma; LUSC cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.92 -13.67 -0.6 4.29e-34 Chronic sinus infection; LUSC trans rs2679649 1.000 rs2679644 chr6:122352782 C/T cg00167820 chr8:131663355 NA 0.54 6.35 0.33 6.96e-10 Subcutaneous adipose tissue; LUSC cis rs4363385 0.776 rs1415957 chr1:152948909 A/G cg07796016 chr1:152779584 LCE1C -0.46 -6.55 -0.34 2.23e-10 Inflammatory skin disease; LUSC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg00074818 chr8:8560427 CLDN23 0.59 10.04 0.48 6.92e-21 Obesity-related traits; LUSC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg09365446 chr1:150670422 GOLPH3L 0.48 6.99 0.36 1.47e-11 Melanoma; LUSC trans rs1728785 1.000 rs12918861 chr16:68566508 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.47 0.38 6.96e-13 Ulcerative colitis; LUSC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg13390004 chr1:15929781 NA 0.42 7.03 0.36 1.18e-11 Systolic blood pressure; LUSC cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs3087591 1.000 rs7216033 chr17:29574642 A/G cg24425628 chr17:29625626 OMG;NF1 -0.55 -8.04 -0.4 1.56e-14 Hip circumference; LUSC cis rs113835537 0.529 rs2276406 chr11:66283257 C/T cg24851651 chr11:66362959 CCS 0.53 7.93 0.4 3.42e-14 Airway imaging phenotypes; LUSC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg05855489 chr10:104503620 C10orf26 -0.71 -10.41 -0.49 3.63e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg23711669 chr6:146136114 FBXO30 0.81 14.02 0.61 1.86e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs7100689 0.622 rs1340373 chr10:82129250 G/A cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC trans rs2204008 0.687 rs2320523 chr12:38251397 T/C cg06521331 chr12:34319734 NA -0.41 -6.38 -0.33 5.95e-10 Bladder cancer; LUSC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg03396347 chr1:1875803 NA 0.39 7.73 0.39 1.27e-13 Body mass index; LUSC cis rs981844 0.816 rs56109239 chr4:154726500 A/G cg14289246 chr4:154710475 SFRP2 0.48 6.18 0.32 1.89e-9 Response to statins (LDL cholesterol change); LUSC trans rs2797160 1.000 rs6904069 chr6:125995134 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.69 -0.34 9.51e-11 Endometrial cancer; LUSC cis rs2197308 0.703 rs10880251 chr12:37903297 G/A cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg22117172 chr7:91764530 CYP51A1 -0.33 -5.85 -0.3 1.19e-8 Breast cancer; LUSC trans rs149866169 1 rs149866169 chr6:27441723 T/A cg06606381 chr12:133084897 FBRSL1 -0.82 -8.03 -0.4 1.72e-14 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; LUSC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.55 0.46 2.78e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg21854759 chr1:92012499 NA -0.55 -9.23 -0.45 3.2e-18 Breast cancer; LUSC cis rs1413885 0.516 rs6588137 chr1:65837282 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.51 7.45 0.38 8.26e-13 Anticoagulant levels; LUSC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg08742575 chr21:47604166 C21orf56 0.38 5.65 0.3 3.36e-8 Testicular germ cell tumor; LUSC cis rs10791097 0.609 rs3751039 chr11:130773076 A/G cg12179176 chr11:130786555 SNX19 -0.93 -18.48 -0.71 5.1e-53 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7809950 1.000 rs10243340 chr7:107090955 A/G cg23024343 chr7:107201750 COG5 -0.54 -8.64 -0.43 2.43e-16 Coronary artery disease; LUSC cis rs5771069 0.933 rs137848 chr22:50440296 A/G cg27068297 chr22:50451975 IL17REL 0.27 5.69 0.3 2.79e-8 Ulcerative colitis; LUSC cis rs2839186 0.807 rs2032226 chr21:47680352 G/A cg08742575 chr21:47604166 C21orf56 0.42 6.4 0.33 5.16e-10 Testicular germ cell tumor; LUSC trans rs11039798 0.764 rs11040208 chr11:49012509 A/G cg15704280 chr7:45808275 SEPT13 0.86 7.15 0.36 5.51e-12 Axial length; LUSC cis rs2742417 0.603 rs2742448 chr3:45764246 C/T cg04837898 chr3:45731254 SACM1L 0.46 6.85 0.35 3.62e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg18479299 chr3:125709523 NA -0.49 -5.67 -0.3 3.06e-8 Blood pressure (smoking interaction); LUSC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.57 8.95 0.44 2.42e-17 Menopause (age at onset); LUSC cis rs6977660 0.652 rs10254427 chr7:19816240 C/T cg05791153 chr7:19748676 TWISTNB 0.62 6.86 0.35 3.45e-11 Thyroid stimulating hormone; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04250904 chr19:12623422 ZNF709 0.51 6.06 0.31 3.74e-9 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.77e-9 Aortic root size; LUSC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg14004847 chr7:1930337 MAD1L1 -0.55 -8.36 -0.42 1.76e-15 Bipolar disorder and schizophrenia; LUSC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg09455208 chr3:40491958 NA -0.51 -9.43 -0.46 7.29e-19 Renal cell carcinoma; LUSC cis rs17818399 0.547 rs13020299 chr2:46758717 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.53 -6.98 -0.36 1.59e-11 Height; LUSC cis rs3096299 0.967 rs3102341 chr16:89450744 G/A cg02187348 chr16:89574699 SPG7 0.52 8.13 0.41 8.4e-15 Multiple myeloma (IgH translocation); LUSC trans rs10435719 0.902 rs7006538 chr8:11804982 A/G cg15556689 chr8:8085844 FLJ10661 0.59 9.07 0.44 1.07e-17 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg08684580 chr7:98029266 BAIAP2L1 0.41 7.35 0.37 1.55e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs2439831 1.000 rs471229 chr15:43733994 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.97 10.94 0.51 5.08e-24 Lung cancer in ever smokers; LUSC cis rs4969178 0.930 rs4580257 chr17:76403028 T/G cg20026190 chr17:76395443 PGS1 0.47 8.04 0.4 1.56e-14 HDL cholesterol levels; LUSC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg26566898 chr11:117069891 TAGLN 0.48 8.4 0.42 1.33e-15 Blood protein levels; LUSC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg13683864 chr3:40499215 RPL14 -1.01 -17.38 -0.69 1.23e-48 Renal cell carcinoma; LUSC cis rs7651039 0.619 rs7640807 chr3:15685137 A/G cg16303742 chr3:15540471 COLQ 0.44 8.35 0.42 1.85e-15 Coronary heart disease; LUSC cis rs6430585 0.583 rs78364332 chr2:136640101 T/C cg07169764 chr2:136633963 MCM6 1.25 19.76 0.73 4.26e-58 Corneal structure; LUSC cis rs344364 0.552 rs388928 chr16:1909657 G/C cg00564555 chr16:1970112 NA 0.38 6.43 0.33 4.34e-10 Glomerular filtration rate in chronic kidney disease; LUSC trans rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05039488 chr6:79577232 IRAK1BP1 0.65 10.29 0.49 9.28e-22 Endometrial cancer; LUSC cis rs79387448 0.638 rs7600961 chr2:103035455 G/A cg09003973 chr2:102972529 NA 0.97 10.11 0.48 3.74e-21 Gut microbiota (bacterial taxa); LUSC cis rs9612 0.718 rs346522 chr19:44262545 C/T cg08581076 chr19:44259116 C19orf61 -0.51 -6.59 -0.34 1.69e-10 Exhaled nitric oxide output; LUSC cis rs5769765 0.874 rs4624 chr22:50281917 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.54 -0.34 2.34e-10 Schizophrenia; LUSC cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg10978503 chr1:24200527 CNR2 0.53 13.15 0.58 4.1e-32 Immature fraction of reticulocytes; LUSC trans rs1491818 0.697 rs973862 chr11:29256133 A/G cg21356630 chr6:167753807 TTLL2 0.36 6.03 0.31 4.36e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs9467773 1.000 rs9393732 chr6:26530898 G/A cg09904177 chr6:26538194 HMGN4 0.76 14.41 0.62 5.82e-37 Intelligence (multi-trait analysis); LUSC cis rs870825 0.616 rs4386643 chr4:185624281 A/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.83 -14.2 -0.61 4e-36 Menarche (age at onset); LUSC cis rs17818399 0.574 rs6544907 chr2:46868319 T/C cg21493583 chr2:46842958 PIGF;CRIPT 0.33 6.02 0.31 4.56e-9 Height; LUSC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg20503657 chr10:835505 NA 0.97 13.03 0.58 1.12e-31 Eosinophil percentage of granulocytes; LUSC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg20503657 chr10:835505 NA 0.79 9.87 0.48 2.49e-20 Eosinophil percentage of granulocytes; LUSC cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg13010199 chr12:38710504 ALG10B 0.65 10.01 0.48 8.31e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7586879 0.639 rs4077678 chr2:25122840 C/G cg04586622 chr2:25135609 ADCY3 0.42 8.79 0.43 7.87e-17 Body mass index; LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC cis rs611744 0.810 rs619227 chr8:109215100 C/A cg18478394 chr8:109455254 TTC35 0.4 5.89 0.31 9.48e-9 Dupuytren's disease; LUSC cis rs6121246 0.821 rs7265413 chr20:30317923 G/A cg13852791 chr20:30311386 BCL2L1 0.9 12.15 0.55 2.14e-28 Mean corpuscular hemoglobin; LUSC cis rs9311676 0.609 rs55797456 chr3:58378206 C/T cg13750441 chr3:58318267 PXK 0.36 6.98 0.36 1.64e-11 Systemic lupus erythematosus; LUSC cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Drug-induced liver injury (flucloxacillin); LUSC trans rs9329221 0.512 rs7843924 chr8:9976540 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.96 0.36 1.83e-11 Neuroticism; LUSC cis rs77106637 0.932 rs17244499 chr11:72629946 C/T cg03713592 chr11:72463424 ARAP1 -0.69 -8.16 -0.41 6.89e-15 Type 2 diabetes; LUSC cis rs3784262 0.867 rs8036453 chr15:58371635 A/G cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.96 -0.31 6.57e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg08392591 chr16:89556376 ANKRD11 0.47 7.09 0.36 8.17e-12 Multiple myeloma (IgH translocation); LUSC cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.43 0.5 3.23e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2346177 0.542 rs6718875 chr2:46687982 G/T cg02822958 chr2:46747628 ATP6V1E2 0.5 8.86 0.44 4.88e-17 HDL cholesterol; LUSC cis rs7312933 0.618 rs7315968 chr12:42637086 G/A cg17420585 chr12:42539391 GXYLT1 -0.33 -6.28 -0.32 1.07e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs12200782 1.000 rs12207181 chr6:26431285 C/T cg11837749 chr1:55047332 ACOT11 0.58 6.23 0.32 1.41e-9 Small cell lung carcinoma; LUSC cis rs9815354 0.638 rs73071259 chr3:42001847 G/A cg03022575 chr3:42003672 ULK4 0.84 8.8 0.43 7.21e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs7959452 0.640 rs11177599 chr12:69721970 G/A cg14784868 chr12:69753453 YEATS4 0.63 9.4 0.46 8.65e-19 Blood protein levels; LUSC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg19077165 chr18:44547161 KATNAL2 -0.37 -5.68 -0.3 2.94e-8 Personality dimensions; LUSC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.54 -7.63 -0.39 2.52e-13 Renal function-related traits (BUN); LUSC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg16423285 chr20:60520624 NA 0.87 11.89 0.55 1.93e-27 Obesity-related traits; LUSC cis rs60843830 1.000 rs62114497 chr2:214837 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.96 0.4 2.78e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1375194 0.606 rs17657783 chr2:33814590 A/G cg04131969 chr2:33951647 MYADML -0.63 -8.84 -0.44 5.4e-17 Response to antidepressants in depression; LUSC cis rs868036 0.609 rs2278076 chr15:68099600 C/T cg05925327 chr15:68127851 NA -0.49 -7.43 -0.38 9.21e-13 Restless legs syndrome; LUSC cis rs28374715 0.681 rs11629979 chr15:41626579 A/G cg18705301 chr15:41695430 NDUFAF1 -0.94 -18.67 -0.71 8.71e-54 Ulcerative colitis; LUSC cis rs6547741 1.000 rs6750943 chr2:27777904 T/G cg27432699 chr2:27873401 GPN1 0.8 15.03 0.64 2.42e-39 Oral cavity cancer; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.67 10.36 0.49 5.33e-22 Lymphocyte counts; LUSC cis rs11155671 0.530 rs9383940 chr6:150226059 T/G cg07701084 chr6:150067640 NUP43 0.45 6.72 0.35 7.84e-11 Testicular germ cell tumor; LUSC cis rs2439831 1.000 rs689754 chr15:43775895 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.98 10.98 0.51 3.76e-24 Lung cancer in ever smokers; LUSC cis rs6121246 1.000 rs6121246 chr20:30433352 C/T cg13852791 chr20:30311386 BCL2L1 0.82 10.72 0.51 3.12e-23 Mean corpuscular hemoglobin; LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg02018176 chr4:1364513 KIAA1530 -0.56 -9.75 -0.47 6.05e-20 Obesity-related traits; LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.15e-8 Developmental language disorder (linguistic errors); LUSC cis rs34779708 0.801 rs12246600 chr10:35538121 A/C cg03585969 chr10:35415529 CREM 0.55 7.67 0.39 1.92e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1595825 0.891 rs57990618 chr2:198660838 C/T cg19156104 chr2:198669113 PLCL1 -0.48 -5.83 -0.3 1.29e-8 Ulcerative colitis; LUSC cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 28.67 0.84 4.56e-92 Chronic sinus infection; LUSC cis rs709400 0.628 rs6575984 chr14:103876454 A/G cg10523860 chr14:103875565 MARK3 0.39 6.21 0.32 1.55e-9 Body mass index; LUSC cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg06636001 chr8:8085503 FLJ10661 0.53 8.04 0.4 1.54e-14 Mood instability; LUSC cis rs62400317 0.859 rs4267941 chr6:45241302 A/C cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.11e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9309473 0.718 rs10175529 chr2:73606093 A/G cg20560298 chr2:73613845 ALMS1 -0.56 -8.14 -0.41 7.85e-15 Metabolite levels; LUSC cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.27 0.59 1.45e-32 Chronic sinus infection; LUSC cis rs9300255 0.544 rs1727310 chr12:123660510 A/G cg00376283 chr12:123451042 ABCB9 0.76 8.36 0.42 1.66e-15 Neutrophil percentage of white cells; LUSC trans rs7824557 0.603 rs7016671 chr8:11182455 A/G cg15556689 chr8:8085844 FLJ10661 0.45 6.69 0.34 9.19e-11 Retinal vascular caliber; LUSC cis rs2963155 0.518 rs10515522 chr5:142758394 A/G cg17617527 chr5:142782415 NR3C1 0.72 8.55 0.42 4.59e-16 Breast cancer; LUSC cis rs1568889 0.838 rs10767708 chr11:28294847 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 12.95 0.58 2.32e-31 Bipolar disorder; LUSC cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg05283184 chr6:79620031 NA -0.46 -8.75 -0.43 1.05e-16 Intelligence (multi-trait analysis); LUSC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg09904177 chr6:26538194 HMGN4 0.42 6.14 0.32 2.41e-9 Schizophrenia; LUSC cis rs5769765 1.000 rs5770741 chr22:50270215 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs2046867 0.862 rs2322611 chr3:72830087 T/G cg25664220 chr3:72788482 NA -0.72 -12.38 -0.56 3.03e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs17685 0.558 rs60787921 chr7:75792844 C/A cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs853679 0.517 rs9380062 chr6:28137569 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Depression; LUSC cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.18 -0.45 4.78e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7241530 0.662 rs9946782 chr18:75888634 C/T cg14642773 chr18:75888474 NA 0.36 5.91 0.31 8.59e-9 Educational attainment (years of education); LUSC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -6.24 -0.32 1.35e-9 Crohn's disease; LUSC cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg27446573 chr6:127587934 RNF146 0.92 15.42 0.64 7.18e-41 Breast cancer; LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg27170947 chr2:26402098 FAM59B 0.68 10.27 0.49 1.11e-21 Gut microbiome composition (summer); LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg05665937 chr4:1216051 CTBP1 -0.37 -5.79 -0.3 1.65e-8 Obesity-related traits; LUSC cis rs611744 0.839 rs638238 chr8:109169152 A/G cg18478394 chr8:109455254 TTC35 0.41 6.19 0.32 1.75e-9 Dupuytren's disease; LUSC cis rs12200560 0.505 rs60879781 chr6:97075466 A/T cg06623918 chr6:96969491 KIAA0776 0.5 7.2 0.37 3.9e-12 Coronary heart disease; LUSC trans rs2562456 0.754 rs58338799 chr19:21521811 G/T cg00806126 chr19:22604979 ZNF98 -0.43 -6.23 -0.32 1.38e-9 Pain; LUSC cis rs17102423 0.559 rs11624169 chr14:65481710 C/G cg11161011 chr14:65562177 MAX -0.72 -9.82 -0.47 3.79e-20 Obesity-related traits; LUSC cis rs2732480 0.500 rs12829841 chr12:48628739 A/G cg04545296 chr12:48745243 ZNF641 0.35 6.39 0.33 5.48e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg27494647 chr7:150038898 RARRES2 0.58 8.54 0.42 4.74e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg04733989 chr22:42467013 NAGA 0.5 7.72 0.39 1.35e-13 Schizophrenia; LUSC cis rs12145833 0.538 rs61833885 chr1:243397188 C/A cg02356786 chr1:243265016 LOC731275 0.69 6.31 0.33 9.05e-10 Obesity (early onset extreme); LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17401966 1.000 rs17401966 chr1:10385471 C/T cg19773385 chr1:10388646 KIF1B 0.54 8.48 0.42 7.41e-16 Hepatocellular carcinoma; LUSC cis rs10416265 0.528 rs7249097 chr19:33589144 T/C cg27124370 chr19:33622961 WDR88 0.55 7.86 0.39 5.46e-14 Bone properties (heel); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19496744 chr17:80231639 CSNK1D -0.56 -6.67 -0.34 1.04e-10 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg27170947 chr2:26402098 FAM59B -0.62 -9.26 -0.45 2.58e-18 Gut microbiome composition (summer); LUSC cis rs7107174 0.892 rs1017907 chr11:77959124 A/T cg02023728 chr11:77925099 USP35 0.45 6.68 0.34 9.85e-11 Testicular germ cell tumor; LUSC cis rs10788264 0.504 rs4751887 chr10:124029758 G/A cg09507567 chr10:124027408 NA 0.55 9.67 0.47 1.18e-19 Total body bone mineral density; LUSC cis rs9811920 0.931 rs7629487 chr3:99860401 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 5.75 0.3 2.02e-8 Axial length; LUSC cis rs7107174 1.000 rs10793303 chr11:78060750 G/A cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC trans rs4911259 0.593 rs6058924 chr20:31464467 G/A cg09781936 chr22:19749961 TBX1 -0.34 -6.01 -0.31 4.74e-9 Inflammatory bowel disease; LUSC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg21433313 chr16:3507492 NAT15 0.41 5.71 0.3 2.53e-8 Body mass index (adult); LUSC cis rs3806843 0.966 rs6891559 chr5:140145206 G/A cg26395211 chr5:140044315 WDR55 -0.4 -6.15 -0.32 2.25e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs9653442 0.835 rs11885529 chr2:100746935 A/G cg07810366 chr2:100720526 AFF3 -0.5 -8.71 -0.43 1.44e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs3820928 0.874 rs10202239 chr2:227901819 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.89 -0.4 4.48e-14 Pulmonary function; LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg07507251 chr3:52567010 NT5DC2 0.32 6.29 0.33 9.79e-10 Bipolar disorder; LUSC trans rs9944715 1.000 rs9951624 chr18:43840829 A/G cg01718231 chr17:29326311 RNF135 -0.55 -7.59 -0.38 3.17e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs12413816 0.963 rs10796116 chr10:13762786 C/T cg16485048 chr10:13749193 FRMD4A -0.48 -8.41 -0.42 1.21e-15 Red cell distribution width; LUSC cis rs72781680 0.898 rs72786298 chr2:24083011 C/T cg20701182 chr2:24300061 SF3B14 0.73 7.31 0.37 2.04e-12 Lymphocyte counts; LUSC cis rs11166629 0.637 rs7816909 chr8:135551597 G/T cg27224718 chr8:135614730 ZFAT -0.51 -7.46 -0.38 7.55e-13 Smoking quantity; LUSC cis rs1670533 1.000 rs6850784 chr4:1059809 G/A cg27284194 chr4:1044797 NA 0.6 8.76 0.43 9.9900000000000006e-17 Recombination rate (females); LUSC cis rs2637266 1.000 rs12260492 chr10:78365242 C/A cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs9467773 1.000 rs4713006 chr6:26519872 A/G cg09904177 chr6:26538194 HMGN4 0.75 14.21 0.61 3.52e-36 Intelligence (multi-trait analysis); LUSC cis rs11971779 0.680 rs4732376 chr7:139098024 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg09455208 chr3:40491958 NA 0.52 9.8 0.47 4.21e-20 Renal cell carcinoma; LUSC cis rs9653442 0.593 rs2309811 chr2:100862359 A/G cg07810366 chr2:100720526 AFF3 -0.4 -6.55 -0.34 2.17e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1983891 0.955 rs6917270 chr6:41548755 A/G cg20194872 chr6:41519635 FOXP4 0.35 6.25 0.32 1.27e-9 Prostate cancer; LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -8.13 -0.41 8.56e-15 Lymphocyte counts; LUSC cis rs10484885 0.878 rs72921934 chr6:90579464 T/A cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.31 -0.41 2.43e-15 QRS interval (sulfonylurea treatment interaction); LUSC cis rs56399783 0.901 rs73047387 chr7:2774125 G/A cg14895029 chr7:2775587 GNA12 0.53 5.77 0.3 1.81e-8 Childhood ear infection; LUSC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg02896835 chr1:92012615 NA -0.59 -9.97 -0.48 1.13e-20 Breast cancer; LUSC trans rs979233 0.502 rs687238 chr5:42084883 G/T cg07010552 chr17:7358735 CHRNB1 0.41 5.96 0.31 6.43e-9 Systemic lupus erythematosus; LUSC cis rs8005677 0.611 rs11624528 chr14:23459156 A/G cg00579484 chr14:23475993 C14orf93 0.43 6.27 0.32 1.1e-9 Cognitive ability (multi-trait analysis); LUSC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg04369109 chr6:150039330 LATS1 -0.6 -8.85 -0.44 5.18e-17 Lung cancer; LUSC cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg23711669 chr6:146136114 FBXO30 0.88 16.35 0.67 1.5e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs1832871 0.965 rs262827 chr6:158683646 A/T cg07165851 chr6:158734300 TULP4 0.38 6.43 0.33 4.36e-10 Height; LUSC cis rs6964587 0.904 rs6465339 chr7:91570790 T/A cg01689657 chr7:91764605 CYP51A1 -0.32 -5.88 -0.31 9.85e-9 Breast cancer; LUSC cis rs76935404 0.811 rs28417358 chr19:41428105 G/A cg04176888 chr19:41596066 CYP2A13 0.38 5.98 0.31 5.73e-9 nicotine metabolite ratio in current smokers; LUSC cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg13256891 chr4:100009986 ADH5 -0.42 -5.69 -0.3 2.74e-8 Alcohol dependence; LUSC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg11764359 chr7:65958608 NA 0.56 7.36 0.37 1.48e-12 Aortic root size; LUSC cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -18.15 -0.7 1.08e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs765787 0.530 rs2413782 chr15:45538490 A/C cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.79 0.6 1.44e-34 Platelet count; LUSC cis rs3768617 0.510 rs1413390 chr1:183096634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs9303401 0.614 rs2007993 chr17:56590643 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.85 13.13 0.58 4.96e-32 Cognitive test performance; LUSC trans rs2243480 1.000 rs458291 chr7:65520479 C/A cg10756647 chr7:56101905 PSPH 0.85 8.22 0.41 4.44e-15 Diabetic kidney disease; LUSC cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC cis rs9926296 0.632 rs7184315 chr16:89799373 C/G cg01097406 chr16:89675127 NA 0.34 6.61 0.34 1.51e-10 Vitiligo; LUSC cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg16145915 chr7:1198662 ZFAND2A -0.47 -8.41 -0.42 1.17e-15 Longevity;Endometriosis; LUSC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg24675658 chr1:53192096 ZYG11B -0.55 -8.83 -0.44 5.91e-17 Monocyte count; LUSC cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg01657329 chr11:68192670 LRP5 -0.44 -6.59 -0.34 1.67e-10 Total body bone mineral density; LUSC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg02018176 chr4:1364513 KIAA1530 0.5 8.54 0.42 4.76e-16 Obesity-related traits; LUSC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg21984481 chr17:79567631 NPLOC4 -0.68 -14.12 -0.61 8.03e-36 Eye color traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12830327 chr11:85339628 TMEM126B;DLG2 0.43 6.58 0.34 1.87e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs59918340 0.692 rs6983780 chr8:142231944 G/A cg23750338 chr8:142222470 SLC45A4 0.58 11.26 0.52 3.68e-25 Immature fraction of reticulocytes; LUSC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg17554472 chr22:41940697 POLR3H -0.47 -5.73 -0.3 2.29e-8 Vitiligo; LUSC cis rs17102423 0.964 rs868814 chr14:65584508 C/T cg11161011 chr14:65562177 MAX -0.64 -10.11 -0.48 3.77e-21 Obesity-related traits; LUSC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg02428538 chr16:24856791 SLC5A11 0.5 5.81 0.3 1.48e-8 Intelligence (multi-trait analysis); LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg18758796 chr5:131593413 PDLIM4 -0.43 -6.89 -0.35 2.72e-11 Blood metabolite levels; LUSC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.18 0.77 1.27e-67 Prudent dietary pattern; LUSC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg03609598 chr5:56110824 MAP3K1 -0.41 -6.09 -0.32 3.02e-9 Initial pursuit acceleration; LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg08280861 chr8:58055591 NA 0.56 5.85 0.3 1.16e-8 Developmental language disorder (linguistic errors); LUSC cis rs10754283 0.967 rs4658307 chr1:90117586 G/T cg21401794 chr1:90099060 LRRC8C 0.62 8.81 0.43 7.07e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs1728785 0.901 rs1103286 chr16:68578625 C/T cg02972257 chr16:68554789 NA -0.49 -6.31 -0.33 8.74e-10 Ulcerative colitis; LUSC cis rs295137 0.836 rs1217456 chr2:201092279 C/T cg23649088 chr2:200775458 C2orf69 0.47 7.06 0.36 9.77e-12 Asthma (bronchodilator response); LUSC cis rs16937 0.662 rs10900472 chr1:205181526 A/G cg21643547 chr1:205240462 TMCC2 -0.35 -6.35 -0.33 7.22e-10 Schizophrenia; LUSC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg10755058 chr3:40428713 ENTPD3 0.33 5.67 0.3 3.16e-8 Renal cell carcinoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18756060 chr2:27294719 LOC100128731 -0.46 -6.64 -0.34 1.3e-10 Electrocardiographic conduction measures; LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg22963979 chr7:1858916 MAD1L1 -0.47 -6.87 -0.35 3.23e-11 Bipolar disorder and schizophrenia; LUSC cis rs17125944 0.615 rs7145392 chr14:53321016 G/A cg00686598 chr14:53173677 PSMC6 -0.62 -5.67 -0.3 3.02e-8 Alzheimer's disease (late onset); LUSC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs6138458 1.000 rs11905625 chr20:24977065 A/C cg06937882 chr20:24974362 C20orf3 -0.44 -7.67 -0.39 1.89e-13 Blood protein levels; LUSC cis rs3540 0.512 rs7176518 chr15:91079637 C/T cg22089800 chr15:90895588 ZNF774 -0.66 -10.25 -0.49 1.24e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6733011 0.578 rs1581250 chr2:99500750 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.38 -0.33 5.98e-10 Bipolar disorder; LUSC cis rs2277425 0.755 rs2277424 chr13:111522420 A/G cg16032841 chr13:111522222 C13orf29 -0.52 -6.22 -0.32 1.49e-9 Sitting height ratio; LUSC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11890956 chr21:40555474 PSMG1 -0.74 -11.25 -0.52 4.21e-25 Menarche (age at onset); LUSC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg24879335 chr3:133465180 TF 0.45 7.74 0.39 1.21e-13 Iron status biomarkers (transferrin levels); LUSC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg20295408 chr7:1910781 MAD1L1 -0.47 -6.7 -0.34 8.73e-11 Schizophrenia; LUSC cis rs9902453 0.791 rs9904051 chr17:28244122 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.31 0.53 2.46e-25 Coffee consumption (cups per day); LUSC cis rs9399135 0.967 rs7741515 chr6:135374368 C/G cg22676075 chr6:135203613 NA -0.45 -7.0 -0.36 1.38e-11 Red blood cell count; LUSC cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.18 -0.45 4.78e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10493773 0.748 rs12758511 chr1:86165987 C/T cg17807903 chr1:86174739 ZNHIT6 -0.49 -11.79 -0.54 4.81e-27 Urate levels in overweight individuals; LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.5 6.24 0.32 1.33e-9 Renal function-related traits (BUN); LUSC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg06808227 chr14:105710500 BRF1 -0.64 -9.35 -0.46 1.33e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg00166722 chr3:10149974 C3orf24 -0.62 -7.4 -0.38 1.11e-12 Alzheimer's disease; LUSC cis rs2486288 0.586 rs12909625 chr15:45572053 C/A cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.9 -0.51 7.23e-24 Glomerular filtration rate; LUSC cis rs1953600 0.645 rs2573351 chr10:81931441 A/G cg00277334 chr10:82204260 NA -0.49 -7.69 -0.39 1.68e-13 Sarcoidosis; LUSC cis rs7246967 0.551 rs34563787 chr19:22837736 A/T cg23217946 chr19:22817039 ZNF492 0.47 5.89 0.31 9.48e-9 Bronchopulmonary dysplasia; LUSC cis rs55665837 1.000 rs11023229 chr11:14461001 G/C cg05501817 chr11:14380813 RRAS2 -0.41 -6.51 -0.34 2.72e-10 Vitamin D levels; LUSC trans rs72674100 1.000 rs10005721 chr4:97983681 G/T cg16405019 chr1:18959625 PAX7 -0.57 -6.19 -0.32 1.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10203711 1.000 rs907100 chr2:239563579 G/C cg14580085 chr2:239553406 NA 0.41 6.88 0.35 2.9100000000000002e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs701145 0.617 rs355775 chr3:154036129 A/G cg17054900 chr3:154042577 DHX36 0.46 5.98 0.31 5.67e-9 Coronary artery disease; LUSC cis rs4363385 0.626 rs12062847 chr1:153062994 A/G cg07796016 chr1:152779584 LCE1C -0.39 -5.83 -0.3 1.27e-8 Inflammatory skin disease; LUSC cis rs9341808 0.644 rs59371711 chr6:80942027 G/T cg08355045 chr6:80787529 NA -0.42 -7.13 -0.36 6.17e-12 Sitting height ratio; LUSC cis rs7089973 0.966 rs749649 chr10:116641999 G/A cg23260525 chr10:116636907 FAM160B1 0.37 7.13 0.36 6.35e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3099143 1.000 rs1913001 chr15:77179408 A/C cg21673338 chr15:77095150 SCAPER 0.78 7.34 0.37 1.64e-12 Recalcitrant atopic dermatitis; LUSC cis rs447735 0.587 rs11647958 chr16:89720909 A/T cg03605463 chr16:89740564 NA 0.56 8.97 0.44 2.21e-17 Hemoglobin concentration; LUSC cis rs1355223 0.506 rs7130774 chr11:34869267 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.67 -0.34 1.05e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg16520312 chr17:43971471 MAPT;LOC100128977 0.36 6.06 0.31 3.76e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs734999 0.588 rs3001837 chr1:2532506 G/A cg18854424 chr1:2615690 NA -0.49 -9.81 -0.47 3.96e-20 Ulcerative colitis; LUSC cis rs9837602 1.000 rs1688766 chr3:99647850 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.37 5.89 0.31 9.38e-9 Breast cancer; LUSC cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 12.05 0.55 5.41e-28 Chronic sinus infection; LUSC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg14829155 chr15:31115871 NA 0.47 6.77 0.35 5.71e-11 Huntington's disease progression; LUSC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg25019033 chr10:957182 NA -0.55 -6.33 -0.33 8e-10 Eosinophil percentage of granulocytes; LUSC cis rs10911232 0.507 rs10752888 chr1:182993751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.7 10.78 0.51 1.95e-23 Hypertriglyceridemia; LUSC cis rs7827545 0.545 rs57219802 chr8:135554231 C/T cg17885191 chr8:135476712 NA 0.65 8.03 0.4 1.65e-14 Hypertension (SNP x SNP interaction); LUSC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.5 5.96 0.31 6.46e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs868036 1.000 rs1026732 chr15:68095085 C/T cg08079166 chr15:68083412 MAP2K5 0.41 8.68 0.43 1.78e-16 Restless legs syndrome; LUSC cis rs6754311 0.773 rs632632 chr2:136638216 A/G cg07169764 chr2:136633963 MCM6 0.56 7.43 0.38 9.28e-13 Mosquito bite size; LUSC cis rs3126085 0.877 rs1552992 chr1:152171625 C/G cg03465714 chr1:152285911 FLG -0.4 -5.75 -0.3 2.05e-8 Atopic dermatitis; LUSC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.27 0.37 2.61e-12 Mean platelet volume; LUSC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.49 9.52 0.46 3.58e-19 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs61931739 0.500 rs3922568 chr12:34560107 A/C cg13010199 chr12:38710504 ALG10B 0.57 9.05 0.44 1.22e-17 Morning vs. evening chronotype; LUSC cis rs6121246 0.511 rs879982 chr20:30398510 A/G cg13852791 chr20:30311386 BCL2L1 0.94 14.61 0.62 1.01e-37 Mean corpuscular hemoglobin; LUSC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg13319975 chr6:146136371 FBXO30 -0.66 -9.92 -0.48 1.64e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg15445000 chr17:37608096 MED1 0.39 6.71 0.34 8.2e-11 Glomerular filtration rate (creatinine); LUSC cis rs10927875 0.965 rs3961710 chr1:16313172 C/T cg21385522 chr1:16154831 NA -0.79 -12.54 -0.57 8.06e-30 Dilated cardiomyopathy; LUSC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg20406979 chr6:167373233 NA -0.26 -6.22 -0.32 1.5e-9 Crohn's disease; LUSC cis rs7937682 0.562 rs955744 chr11:111374334 C/T cg09085632 chr11:111637200 PPP2R1B 0.53 7.19 0.37 4.2e-12 Primary sclerosing cholangitis; LUSC trans rs11039798 0.688 rs10839007 chr11:48703442 A/C cg03929089 chr4:120376271 NA 0.74 6.95 0.36 1.87e-11 Axial length; LUSC cis rs9463078 0.605 rs9472407 chr6:44908800 T/C cg25276700 chr6:44698697 NA 0.29 6.06 0.31 3.59e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2130392 1.000 rs2130392 chr4:185639169 A/G cg04058563 chr4:185651563 MLF1IP 0.44 7.55 0.38 4.13e-13 Kawasaki disease; LUSC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs55883249 0.957 rs17362839 chr2:9754439 T/C cg23886495 chr2:9695866 ADAM17 0.48 5.75 0.3 2.07e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2439831 1.000 rs561863 chr15:43761352 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs7575217 0.767 rs13400798 chr2:101750350 C/T cg23907051 chr2:101730305 TBC1D8 -0.28 -7.38 -0.37 1.24e-12 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.82e-8 Depression; LUSC cis rs7107174 0.681 rs881337 chr11:78128335 G/C cg02023728 chr11:77925099 USP35 0.43 6.58 0.34 1.77e-10 Testicular germ cell tumor; LUSC trans rs7829975 0.688 rs7817376 chr8:8380530 C/T cg21775007 chr8:11205619 TDH -0.46 -6.94 -0.36 2.03e-11 Mood instability; LUSC cis rs11031096 0.641 rs232054 chr11:4123427 C/G cg18678763 chr11:4115507 RRM1 0.38 5.73 0.3 2.29e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11122272 0.701 rs2749702 chr1:231523808 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs4925114 0.532 rs11655029 chr17:17649172 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.49 -7.24 -0.37 3.05e-12 Body mass index; LUSC cis rs1348850 0.958 rs11684320 chr2:178456346 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.29 0.33 9.72e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg20608306 chr11:116969690 SIK3 0.4 6.68 0.34 9.91e-11 Blood protein levels; LUSC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg03433033 chr1:76189801 ACADM 0.8 12.57 0.57 6.1e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs981844 0.712 rs10014763 chr4:154739140 C/T cg14289246 chr4:154710475 SFRP2 0.44 5.94 0.31 7.3e-9 Response to statins (LDL cholesterol change); LUSC cis rs10779751 1.000 rs7525957 chr1:11318236 C/T cg08854313 chr1:11322531 MTOR 0.89 15.01 0.63 2.78e-39 Body mass index; LUSC cis rs9534288 0.664 rs1926446 chr13:46629995 A/C cg15192986 chr13:46630673 CPB2 0.72 11.49 0.53 5.82e-26 Blood protein levels; LUSC cis rs1499972 0.887 rs73168397 chr3:117657197 C/T cg07612923 chr3:117604196 NA 0.63 5.71 0.3 2.49e-8 Schizophrenia; LUSC cis rs7131987 0.903 rs11050152 chr12:29404424 G/T cg09582351 chr12:29534625 ERGIC2 -0.34 -6.91 -0.35 2.44e-11 QT interval; LUSC cis rs6977660 0.714 rs12530537 chr7:19822641 A/G cg05791153 chr7:19748676 TWISTNB -0.63 -6.85 -0.35 3.67e-11 Thyroid stimulating hormone; LUSC cis rs1322512 0.917 rs2758781 chr6:153008828 C/T cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs3741798 1.000 rs61922049 chr12:12497395 C/T cg08615371 chr12:12503544 MANSC1 1.08 11.07 0.52 1.79e-24 Cerebrospinal fluid biomarker levels; LUSC cis rs734999 0.588 rs10910099 chr1:2533552 G/T cg18854424 chr1:2615690 NA -0.5 -10.01 -0.48 8.72e-21 Ulcerative colitis; LUSC cis rs62158211 1.000 rs1807282 chr2:114110036 A/T cg17784749 chr2:114082611 LOC440839 0.51 6.06 0.31 3.71e-9 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; LUSC cis rs2348418 0.864 rs7977850 chr12:28715648 C/T cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg22535103 chr8:58192502 C8orf71 -0.73 -7.44 -0.38 8.49e-13 Developmental language disorder (linguistic errors); LUSC trans rs2736345 0.502 rs12680762 chr8:11332026 A/G cg15556689 chr8:8085844 FLJ10661 -0.52 -7.22 -0.37 3.58e-12 Sjögren's syndrome;Systemic lupus erythematosus; LUSC trans rs3903072 0.528 rs12800497 chr11:65579762 C/T cg17712092 chr4:129076599 LARP1B 0.55 7.09 0.36 7.88e-12 Breast cancer; LUSC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg18099408 chr3:52552593 STAB1 -0.42 -7.27 -0.37 2.59e-12 Bipolar disorder; LUSC cis rs1957429 0.614 rs75819890 chr14:65370321 T/G cg23373153 chr14:65346875 NA -1.01 -8.51 -0.42 6.09e-16 Pediatric areal bone mineral density (radius); LUSC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs11585357 0.793 rs11587669 chr1:17616259 C/T cg08277548 chr1:17600880 PADI3 -0.63 -6.51 -0.34 2.7e-10 Hair shape; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14974841 chr3:51975970 PARP3;RRP9 -0.41 -6.01 -0.31 4.81e-9 Electrocardiographic conduction measures; LUSC cis rs8062405 0.755 rs1074631 chr16:28554108 A/G cg16576597 chr16:28551801 NUPR1 -0.32 -6.31 -0.33 9.02e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs34779708 0.966 rs11010095 chr10:35395948 A/G cg04310649 chr10:35416472 CREM -0.41 -6.32 -0.33 8.54e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg13057898 chr1:3703894 LRRC47 0.51 8.88 0.44 4.14e-17 Red cell distribution width; LUSC cis rs909002 0.800 rs3753613 chr1:32082000 C/T cg01639898 chr1:32083012 HCRTR1 -0.32 -7.72 -0.39 1.34e-13 Intelligence (multi-trait analysis); LUSC cis rs74181299 0.927 rs2723064 chr2:65279805 T/C cg05010058 chr2:65284262 CEP68 0.31 6.21 0.32 1.54e-9 Pulse pressure; LUSC trans rs9329221 0.905 rs17709397 chr8:10249861 G/A cg08975724 chr8:8085496 FLJ10661 -0.48 -6.98 -0.36 1.63e-11 Neuroticism; LUSC cis rs7613051 0.947 rs13093698 chr3:33063050 A/G cg19000631 chr3:33138515 GLB1;TMPPE 0.49 5.84 0.3 1.24e-8 Atopic dermatitis; LUSC cis rs9653442 0.564 rs56054309 chr2:100794940 T/C cg07810366 chr2:100720526 AFF3 -0.42 -7.18 -0.37 4.46e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs10751667 0.600 rs6597948 chr11:1005308 C/T ch.11.42038R chr11:967971 AP2A2 0.47 7.07 0.36 8.92e-12 Alzheimer's disease (late onset); LUSC trans rs11098499 0.697 rs6832410 chr4:120296800 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.01 0.4 1.89e-14 Corneal astigmatism; LUSC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg07741184 chr6:167504864 NA 0.38 6.8 0.35 4.7e-11 Crohn's disease; LUSC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11190604 0.697 rs12355942 chr10:102201320 T/C cg07080220 chr10:102295463 HIF1AN -0.62 -8.25 -0.41 3.73e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12618769 0.597 rs3754891 chr2:99088018 T/C cg10123293 chr2:99228465 UNC50 0.43 7.06 0.36 9.74e-12 Bipolar disorder; LUSC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg21033440 chr11:65409861 SIPA1 -0.51 -7.47 -0.38 6.93e-13 Blood pressure (age interaction); LUSC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg18850127 chr7:39170497 POU6F2 0.63 10.19 0.49 2.09e-21 IgG glycosylation; LUSC cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.38 -0.37 1.23e-12 Psoriasis; LUSC cis rs35306767 0.623 rs36051896 chr10:1155747 T/C cg26597838 chr10:835615 NA 0.52 6.07 0.32 3.42e-9 Eosinophil percentage of granulocytes; LUSC cis rs977987 0.806 rs4888383 chr16:75386349 C/T cg04384234 chr16:75411784 CFDP1 -0.39 -6.25 -0.32 1.22e-9 Dupuytren's disease; LUSC cis rs3736594 0.879 rs77154381 chr2:27982119 A/G cg27432699 chr2:27873401 GPN1 0.65 9.21 0.45 3.79e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg02038168 chr22:39784481 NA -0.49 -7.88 -0.4 4.79e-14 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg09267113 chr7:98030324 BAIAP2L1 0.41 6.23 0.32 1.41e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.46 0.38 7.78e-13 Motion sickness; LUSC cis rs4654899 1.000 rs10799685 chr1:21465930 A/C cg01072550 chr1:21505969 NA 0.53 8.19 0.41 5.55e-15 Superior frontal gyrus grey matter volume; LUSC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg06850241 chr22:41845214 NA 0.34 6.3 0.33 9.5e-10 Vitiligo; LUSC cis rs10779751 1.000 rs6670821 chr1:11308762 T/C cg08854313 chr1:11322531 MTOR 0.87 14.95 0.63 4.62e-39 Body mass index; LUSC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg03465714 chr1:152285911 FLG -0.36 -6.41 -0.33 4.84e-10 Inflammatory skin disease; LUSC cis rs6762 0.719 rs7936806 chr11:839186 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.29 -0.41 2.82e-15 Mean platelet volume; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 20.42 0.75 1.03e-60 Prudent dietary pattern; LUSC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg02574844 chr11:5959923 NA -0.43 -5.96 -0.31 6.58e-9 DNA methylation (variation); LUSC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.44 -0.33 4.22e-10 Height; LUSC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.66 -0.39 2.01e-13 Developmental language disorder (linguistic errors); LUSC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg06074448 chr4:187884817 NA 0.4 6.78 0.35 5.38e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg22800045 chr5:56110881 MAP3K1 0.77 9.59 0.46 2.16e-19 Initial pursuit acceleration; LUSC cis rs1150668 0.699 rs1736895 chr6:28219826 G/A cg21251018 chr6:28226885 NKAPL 0.33 6.38 0.33 5.84e-10 Pubertal anthropometrics; LUSC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg27121462 chr16:89883253 FANCA -0.54 -8.59 -0.43 3.34e-16 Vitiligo; LUSC cis rs6740322 0.895 rs28456986 chr2:43553321 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.49 -0.38 6.29e-13 Coronary artery disease; LUSC cis rs9811920 0.809 rs1384062 chr3:99597928 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 6.57 0.34 1.89e-10 Axial length; LUSC cis rs4363385 0.818 rs4452994 chr1:152986871 G/A cg00922841 chr1:152955080 SPRR1A -0.42 -7.16 -0.36 5.23e-12 Inflammatory skin disease; LUSC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg18512352 chr11:47633146 NA -0.46 -9.25 -0.45 2.82e-18 Subjective well-being; LUSC cis rs9611565 0.546 rs34077262 chr22:42061639 A/G cg03806693 chr22:41940476 POLR3H 0.93 13.54 0.6 1.3e-33 Vitiligo; LUSC cis rs1153858 0.945 rs16943246 chr15:45720597 G/A cg10760299 chr15:45669010 GATM 0.4 5.68 0.3 2.99e-8 Homoarginine levels; LUSC cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.51e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg21724239 chr8:58056113 NA 0.69 7.54 0.38 4.44e-13 Developmental language disorder (linguistic errors); LUSC cis rs9807989 0.839 rs3755276 chr2:102978459 C/T cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs7568458 0.660 rs55692129 chr2:85792404 A/T cg02493740 chr2:85810744 VAMP5 -0.53 -9.2 -0.45 3.97e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10489202 1.000 rs718885 chr1:167954659 A/G cg24449463 chr1:168025552 DCAF6 -0.58 -7.37 -0.37 1.32e-12 Schizophrenia; LUSC cis rs16866061 1.000 rs1568750 chr2:225342597 A/T cg12698349 chr2:225449008 CUL3 0.87 14.27 0.62 2.11e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs28735056 0.508 rs67651675 chr18:77673562 A/G cg20368463 chr18:77673604 PQLC1 -1.0 -19.3 -0.73 2.84e-56 Schizophrenia; LUSC cis rs2219968 0.962 rs6999835 chr8:78948855 T/C cg00738934 chr8:78996279 NA 0.37 6.62 0.34 1.47e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6426558 0.559 rs2813947 chr1:227459413 G/T cg10327440 chr1:227177885 CDC42BPA 0.55 7.41 0.38 1.02e-12 Neutrophil percentage of white cells; LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg04871131 chr7:94954202 PON1 -0.38 -6.75 -0.35 6.73e-11 Paraoxonase activity; LUSC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg12927641 chr6:109611667 NA -0.43 -7.6 -0.38 2.93e-13 Reticulocyte fraction of red cells; LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg11645453 chr3:52864694 ITIH4 0.38 8.65 0.43 2.25e-16 Bipolar disorder; LUSC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.44e-10 Extrinsic epigenetic age acceleration; LUSC cis rs11077998 0.844 rs12185254 chr17:80498972 C/T cg10255544 chr17:80519551 FOXK2 0.41 6.73 0.35 7.32e-11 Reticulocyte fraction of red cells; LUSC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg09267113 chr7:98030324 BAIAP2L1 0.39 5.9 0.31 8.8e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs2243480 0.808 rs12698508 chr7:65411958 A/T cg10756647 chr7:56101905 PSPH 0.87 8.46 0.42 8.27e-16 Diabetic kidney disease; LUSC cis rs4566357 0.615 rs6436644 chr2:227914275 T/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.29 -0.41 2.72e-15 Coronary artery disease; LUSC cis rs870825 0.616 rs72705689 chr4:185639894 A/G cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs4363385 0.747 rs2075739 chr1:152975495 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.43e-8 Inflammatory skin disease; LUSC cis rs17030434 1.000 rs12646758 chr4:154731625 A/G cg14289246 chr4:154710475 SFRP2 -0.52 -6.96 -0.36 1.82e-11 Electrocardiographic conduction measures; LUSC trans rs11098499 0.954 rs7436506 chr4:120393769 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.28 0.32 1.08e-9 Corneal astigmatism; LUSC cis rs710216 0.957 rs841570 chr1:43435571 C/G cg03128534 chr1:43423976 SLC2A1 0.45 5.74 0.3 2.1e-8 Red cell distribution width; LUSC cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg00012203 chr2:219082015 ARPC2 -0.77 -12.98 -0.58 1.74e-31 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs6494488 0.500 rs112226132 chr15:64911475 A/G cg08069370 chr15:64387884 SNX1 -0.65 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs12776158 0.901 rs56979471 chr10:71216760 G/A cg12610070 chr10:71211762 TSPAN15 -0.46 -6.05 -0.31 3.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9039 0.959 rs12148920 chr16:9183900 C/G cg08831531 chr16:9218945 NA 0.66 10.28 0.49 9.93e-22 Menopause (age at onset); LUSC cis rs9660992 0.700 rs7547565 chr1:205259402 G/A cg21545522 chr1:205238299 TMCC2 -0.47 -8.97 -0.44 2.16e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10876993 0.890 rs2619441 chr12:58083015 C/A cg18357645 chr12:58087776 OS9 0.58 8.75 0.43 1.05e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.81 0.35 4.44e-11 Rheumatoid arthritis; LUSC trans rs6598955 0.617 rs11247883 chr1:26576247 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs6901250 0.523 rs592669 chr6:117090944 T/C cg12892004 chr6:117198278 RFX6 0.37 6.63 0.34 1.34e-10 C-reactive protein levels; LUSC cis rs738322 0.600 rs5995542 chr22:38558141 C/T cg25457927 chr22:38595422 NA -0.34 -6.81 -0.35 4.62e-11 Cutaneous nevi; LUSC cis rs7147624 0.882 rs1956008 chr14:66085429 G/T cg03016385 chr14:66212404 NA -0.82 -9.13 -0.45 6.78e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3847687 0.901 rs12370258 chr12:131527301 G/T cg25772418 chr12:131519998 GPR133 -0.27 -5.82 -0.3 1.4e-8 Longevity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11332484 chr1:20208967 OTUD3 -0.44 -6.53 -0.34 2.5e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg07092213 chr7:1199455 ZFAND2A -0.63 -10.04 -0.48 6.71e-21 Longevity;Endometriosis; LUSC cis rs41271473 1.000 rs17352654 chr1:228878193 T/C cg10167378 chr1:228756711 NA 0.54 6.59 0.34 1.72e-10 Chronic lymphocytic leukemia; LUSC cis rs9473147 0.516 rs9381564 chr6:47443806 A/G cg20196966 chr6:47445060 CD2AP 0.42 5.78 0.3 1.74e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs12410462 0.681 rs74582965 chr1:227610126 C/T cg04117972 chr1:227635322 NA 0.74 7.79 0.39 8.75e-14 Major depressive disorder; LUSC cis rs796364 0.625 rs4673837 chr2:201131159 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.55 6.52 0.34 2.61e-10 Schizophrenia; LUSC cis rs3789045 0.560 rs4626956 chr1:204407298 T/C cg17419461 chr1:204415978 PIK3C2B -0.51 -5.9 -0.31 9.07e-9 Educational attainment (college completion); LUSC cis rs367943 1.000 rs348963 chr5:112819027 A/G cg12552261 chr5:112820674 MCC -0.42 -6.77 -0.35 5.78e-11 Type 2 diabetes; LUSC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11890956 chr21:40555474 PSMG1 -0.91 -16.63 -0.67 1.17e-45 Cognitive function; LUSC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg05043794 chr9:111880884 C9orf5 -0.4 -8.75 -0.43 1.09e-16 Menarche (age at onset); LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg20887711 chr4:1340912 KIAA1530 0.42 6.18 0.32 1.87e-9 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20696912 chr3:183146011 MCF2L2 -0.4 -6.04 -0.31 4.05e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs11264799 0.765 rs12125713 chr1:157636657 A/G cg18268488 chr1:157545234 FCRL4 0.33 5.8 0.3 1.53e-8 IgA nephropathy; LUSC trans rs7829975 0.623 rs10087493 chr8:8373557 A/G cg21775007 chr8:11205619 TDH -0.45 -6.43 -0.33 4.31e-10 Mood instability; LUSC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg22875332 chr1:76189707 ACADM -0.76 -10.36 -0.49 5.26e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs56283067 0.887 rs12215095 chr6:44756910 T/C cg18551225 chr6:44695536 NA -0.46 -7.41 -0.38 1.01e-12 Total body bone mineral density; LUSC cis rs7100689 0.697 rs4934084 chr10:82116960 T/C cg00277334 chr10:82204260 NA -0.49 -6.77 -0.35 5.73e-11 Post bronchodilator FEV1; LUSC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg09835421 chr16:68378352 PRMT7 -0.54 -6.12 -0.32 2.56e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs1538970 0.961 rs7553318 chr1:45843086 A/G cg06784218 chr1:46089804 CCDC17 0.31 5.69 0.3 2.81e-8 Platelet count; LUSC cis rs7089973 0.604 rs7919649 chr10:116609576 T/C cg03647239 chr10:116582469 FAM160B1 0.44 7.14 0.36 5.78e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9311676 0.656 rs4681679 chr3:58332068 A/G cg26110898 chr3:58419937 PDHB -0.43 -6.96 -0.36 1.85e-11 Systemic lupus erythematosus; LUSC cis rs6977660 0.714 rs6945533 chr7:19813913 G/C cg07541023 chr7:19748670 TWISTNB 0.66 7.21 0.37 3.71e-12 Thyroid stimulating hormone; LUSC cis rs3824867 0.920 rs3740684 chr11:47468820 C/T cg20307385 chr11:47447363 PSMC3 0.64 9.48 0.46 4.83e-19 Mean corpuscular hemoglobin; LUSC cis rs3740713 0.748 rs35292478 chr11:18429991 A/C cg07915343 chr11:18477680 LDHAL6A -0.49 -6.11 -0.32 2.84e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs3740713 0.592 rs73434674 chr11:18411497 C/A cg07915343 chr11:18477680 LDHAL6A -0.46 -5.84 -0.3 1.26e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6987853 0.787 rs2923402 chr8:42445400 G/A cg09913449 chr8:42400586 C8orf40 0.5 8.6 0.43 3.23e-16 Mean corpuscular hemoglobin concentration; LUSC trans rs6952808 0.594 rs3778965 chr7:2138296 G/A cg04565464 chr8:145669602 NFKBIL2 0.37 5.99 0.31 5.49e-9 Bipolar disorder and schizophrenia; LUSC cis rs6076065 0.748 rs6048779 chr20:23374709 C/G cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs9325144 0.647 rs35138700 chr12:38804474 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.47 -0.38 7.17e-13 Morning vs. evening chronotype; LUSC cis rs3931020 0.671 rs1327088 chr1:75255491 A/G cg02709834 chr1:75198841 CRYZ;TYW3 0.38 5.82 0.3 1.36e-8 Resistin levels; LUSC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg07507251 chr3:52567010 NT5DC2 0.31 5.98 0.31 5.7e-9 Bipolar disorder; LUSC cis rs3126085 0.935 rs4845741 chr1:152183474 A/G cg03465714 chr1:152285911 FLG -0.41 -5.86 -0.31 1.09e-8 Atopic dermatitis; LUSC cis rs713477 1.000 rs10782426 chr14:55890702 G/A cg13175173 chr14:55914753 NA -0.29 -5.94 -0.31 7.17e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg05973401 chr12:123451056 ABCB9 0.51 6.24 0.32 1.33e-9 Neutrophil percentage of white cells; LUSC cis rs911119 1.000 rs6515375 chr20:23610841 G/A cg16589663 chr20:23618590 CST3 0.6 7.01 0.36 1.36e-11 Chronic kidney disease; LUSC cis rs35146811 0.735 rs1727130 chr7:99811464 C/G cg13334819 chr7:99746414 C7orf59 0.5 6.79 0.35 5.04e-11 Coronary artery disease; LUSC cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.42e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs3790645 1.000 rs369385 chr1:26893229 C/T cg17456097 chr1:26900765 RPS6KA1 0.42 6.03 0.31 4.23e-9 Glucose homeostasis traits; LUSC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg26380479 chr7:97908229 NA -0.27 -5.83 -0.3 1.31e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg15691649 chr6:25882328 NA -0.38 -6.14 -0.32 2.36e-9 Blood metabolite levels; LUSC cis rs68170813 0.527 rs78133594 chr7:107025260 T/C cg02696742 chr7:106810147 HBP1 -0.61 -8.98 -0.44 2.05e-17 Coronary artery disease; LUSC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg17294928 chr15:75287854 SCAMP5 -0.83 -11.23 -0.52 4.94e-25 Blood trace element (Zn levels); LUSC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg02915803 chr1:1606292 LOC728661;CDK11B 0.37 5.7 0.3 2.59e-8 Body mass index; LUSC cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg13256891 chr4:100009986 ADH5 -0.46 -6.44 -0.33 4.23e-10 Alcohol dependence; LUSC cis rs11098499 0.863 rs11947234 chr4:120474859 A/G cg24375607 chr4:120327624 NA 0.75 11.05 0.52 2.18e-24 Corneal astigmatism; LUSC cis rs11098499 0.863 rs3822190 chr4:120428098 G/A cg09307838 chr4:120376055 NA 0.75 10.72 0.51 3.04e-23 Corneal astigmatism; LUSC cis rs3540 0.513 rs2589974 chr15:90891566 C/T cg10434728 chr15:90938212 IQGAP1 -0.38 -7.93 -0.4 3.42e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.66 14.47 0.62 3.51e-37 Hemoglobin concentration; LUSC cis rs7954584 0.635 rs7309024 chr12:122338334 C/T cg21016266 chr12:122356598 WDR66 0.58 8.74 0.43 1.17e-16 Mean corpuscular volume; LUSC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15664640 chr17:80829946 TBCD -0.75 -13.68 -0.6 3.81e-34 Breast cancer; LUSC cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg23711669 chr6:146136114 FBXO30 0.88 16.22 0.66 4.78e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs11650494 0.908 rs74830554 chr17:47431950 G/A cg08112188 chr17:47440006 ZNF652 1.27 10.65 0.5 5.39e-23 Prostate cancer; LUSC trans rs9467711 0.591 rs9461219 chr6:25836927 C/G cg06606381 chr12:133084897 FBRSL1 0.6 6.03 0.31 4.39e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.38 0.33 5.94e-10 Personality dimensions; LUSC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs4423214 1.000 rs3794060 chr11:71187679 C/T cg05163923 chr11:71159392 DHCR7 0.75 11.19 0.52 6.57e-25 Vitamin D levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24341944 chr3:157827791 RSRC1 0.36 6.02 0.31 4.53e-9 Triglycerides; LUSC cis rs9473147 0.516 rs9395286 chr6:47575332 T/C cg20196966 chr6:47445060 CD2AP 0.43 6.07 0.32 3.55e-9 Platelet distribution width;Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27252137 chr12:124155579 TCTN2 0.5 6.78 0.35 5.32e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9916302 0.706 rs6503504 chr17:37514412 A/G cg07936489 chr17:37558343 FBXL20 0.8 9.85 0.47 2.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs950027 0.620 rs1617634 chr15:45615578 A/G cg26924012 chr15:45694286 SPATA5L1 0.8 12.45 0.56 1.8e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg05855489 chr10:104503620 C10orf26 -0.71 -10.34 -0.49 6.51e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.11e-11 Crohn's disease; LUSC cis rs13256369 0.853 rs13256216 chr8:8577883 C/T cg17143192 chr8:8559678 CLDN23 0.6 8.07 0.4 1.26e-14 Obesity-related traits; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg17749735 chr1:155051360 EFNA3 0.36 6.07 0.32 3.52e-9 Schizophrenia (age at onset); LUSC cis rs6063312 0.935 rs6066827 chr20:47341005 T/C cg18078177 chr20:47281410 PREX1 0.61 7.34 0.37 1.67e-12 Tonometry; LUSC cis rs6545883 0.602 rs11125871 chr2:61470126 C/T cg15711740 chr2:61764176 XPO1 0.4 6.15 0.32 2.21e-9 Tuberculosis; LUSC cis rs12042938 0.902 rs1094658 chr1:231773397 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.43 6.28 0.33 1.05e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs4268898 0.722 rs7564420 chr2:24414002 C/T cg06627628 chr2:24431161 ITSN2 -0.58 -8.19 -0.41 5.69e-15 Asthma; LUSC cis rs2667011 0.570 rs4664305 chr2:160859235 A/G cg06573604 chr2:160760825 LY75 0.48 6.67 0.34 1.03e-10 Bilirubin levels; LUSC cis rs11031096 0.702 rs11030980 chr11:4130543 C/G cg18678763 chr11:4115507 RRM1 0.38 5.72 0.3 2.39e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg02487499 chr1:33937968 ZSCAN20 0.48 6.14 0.32 2.32e-9 Neuroticism; LUSC cis rs72781680 0.716 rs78332127 chr2:24150163 C/G cg08917208 chr2:24149416 ATAD2B 0.6 6.85 0.35 3.66e-11 Lymphocyte counts; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25858983 chr17:42295711 UBTF -0.36 -6.18 -0.32 1.83e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.11 -0.32 2.77e-9 Major depressive disorder; LUSC cis rs2658782 0.654 rs2605617 chr11:93243333 T/C cg15737290 chr11:93063684 CCDC67 0.64 8.11 0.41 9.62e-15 Pulmonary function decline; LUSC cis rs73198271 0.855 rs57301822 chr8:8608642 C/T cg15556689 chr8:8085844 FLJ10661 -0.53 -6.63 -0.34 1.37e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12410462 0.681 rs4131980 chr1:227572123 A/G cg23173402 chr1:227635558 NA 0.56 6.28 0.32 1.07e-9 Major depressive disorder; LUSC cis rs539096 0.692 rs6669157 chr1:44216876 T/C cg15962314 chr1:44399869 ARTN 0.24 5.73 0.3 2.28e-8 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg15117754 chr3:10150083 C3orf24 0.44 5.71 0.3 2.53e-8 Alzheimer's disease; LUSC cis rs9341808 0.718 rs9448898 chr6:80845341 T/A cg08355045 chr6:80787529 NA 0.57 10.03 0.48 6.94e-21 Sitting height ratio; LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg10862848 chr6:42927986 GNMT -0.28 -6.56 -0.34 2.01e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg09517075 chr8:22133004 PIWIL2 0.41 8.18 0.41 6.01e-15 Hypertriglyceridemia; LUSC trans rs7824557 0.767 rs11250127 chr8:11170209 G/A cg15556689 chr8:8085844 FLJ10661 0.56 8.54 0.42 4.93e-16 Retinal vascular caliber; LUSC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg02574844 chr11:5959923 NA -0.42 -6.06 -0.31 3.6e-9 DNA methylation (variation); LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg23034840 chr1:205782522 SLC41A1 0.59 8.28 0.41 2.93e-15 Menarche (age at onset); LUSC cis rs9902453 0.765 rs2259857 chr17:28097780 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.71 -0.54 9.26e-27 Coffee consumption (cups per day); LUSC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg25838465 chr1:92012736 NA 0.72 14.49 0.62 2.98e-37 Breast cancer; LUSC cis rs9640161 0.830 rs3757425 chr7:150067640 A/C cg10018233 chr7:150070692 REPIN1 0.46 9.38 0.46 1.06e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs2282300 0.739 rs34951229 chr11:30265166 C/G cg25418670 chr11:30344373 C11orf46 -0.65 -9.34 -0.45 1.43e-18 Morning vs. evening chronotype; LUSC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg23719950 chr11:63933701 MACROD1 -0.38 -6.08 -0.32 3.31e-9 Platelet count; LUSC cis rs10465746 0.657 rs67045520 chr1:84414998 G/T cg10977910 chr1:84465055 TTLL7 0.43 6.24 0.32 1.32e-9 Obesity-related traits; LUSC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.43 -6.84 -0.35 3.78e-11 Mean platelet volume; LUSC cis rs8038465 0.967 rs61012032 chr15:73973978 C/T cg15420318 chr15:73925796 NPTN 0.43 7.01 0.36 1.36e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2730245 0.527 rs712199 chr7:158662250 A/G cg11984989 chr7:158649758 WDR60 1.1 13.96 0.61 3.25e-35 Height; LUSC cis rs1443512 0.812 rs4759058 chr12:54339052 C/A cg17410650 chr12:54324560 NA -0.58 -9.95 -0.48 1.3e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs644799 0.511 rs11021302 chr11:95485768 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.56 7.46 0.38 7.77e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4970988 0.526 rs6655975 chr1:150542128 A/G cg04414720 chr1:150670196 GOLPH3L -0.48 -7.11 -0.36 7.21e-12 Urate levels; LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.43 6.88 0.35 3.03e-11 Menopause (age at onset); LUSC cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.47 0.38 7.16e-13 Motion sickness; LUSC cis rs1577917 0.958 rs10944147 chr6:86550786 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.77 -0.43 9.17e-17 Response to antipsychotic treatment; LUSC cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg20476274 chr7:133979776 SLC35B4 0.8 13.24 0.59 1.79e-32 Mean platelet volume; LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.61 -0.43 2.94e-16 Developmental language disorder (linguistic errors); LUSC cis rs1348850 0.609 rs1348851 chr2:178418677 C/T cg27490568 chr2:178487706 NA -0.42 -5.78 -0.3 1.73e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7197653 0.667 rs16957831 chr16:68378341 C/T cg09835421 chr16:68378352 PRMT7 -0.76 -8.49 -0.42 7.06e-16 Magnesium levels; LUSC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg22868518 chr11:507468 RNH1 -0.6 -6.04 -0.31 4.07e-9 Body mass index; LUSC cis rs35094601 0.731 rs10180719 chr2:139214202 C/T cg10095539 chr2:139258744 SPOPL 0.25 5.86 0.31 1.13e-8 Schizophrenia; LUSC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg24531977 chr5:56204891 C5orf35 -0.72 -10.33 -0.49 6.8e-22 Coronary artery disease; LUSC cis rs7568458 0.846 rs10179195 chr2:85762761 A/G cg17127132 chr2:85788382 GGCX 0.44 7.0 0.36 1.43e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11711311 1.000 rs1043132 chr3:113528689 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.69 0.34 9.21e-11 IgG glycosylation; LUSC cis rs8060686 0.641 rs12447640 chr16:68150527 A/G cg09835421 chr16:68378352 PRMT7 -0.55 -6.17 -0.32 1.92e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs9951602 0.512 rs6506874 chr18:76653467 G/T cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.39 -0.46 9.7e-19 Bone mineral density; LUSC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg16405210 chr4:1374714 KIAA1530 -0.56 -8.26 -0.41 3.53e-15 Obesity-related traits; LUSC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg12436631 chr1:155007014 DCST1;DCST2 -0.44 -10.04 -0.48 6.63e-21 Schizophrenia; LUSC trans rs3942852 0.868 rs58407618 chr11:48104167 T/G cg15704280 chr7:45808275 SEPT13 -0.53 -6.12 -0.32 2.57e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs9486719 0.802 rs2983896 chr6:97029871 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -11.55 -0.53 3.45e-26 Migraine;Coronary artery disease; LUSC cis rs9549367 0.713 rs9549681 chr13:113829873 T/C cg00898013 chr13:113819073 PROZ -0.64 -8.93 -0.44 2.89e-17 Platelet distribution width; LUSC cis rs524023 1.000 rs559946 chr11:64358605 T/C cg19131476 chr11:64387923 NRXN2 0.37 9.84 0.47 3.17e-20 Urate levels in obese individuals; LUSC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg06640241 chr16:89574553 SPG7 0.84 14.95 0.63 4.7e-39 Multiple myeloma (IgH translocation); LUSC cis rs3806843 0.576 rs246047 chr5:140328337 C/T cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg07212818 chr11:638076 DRD4 -0.38 -6.49 -0.33 3.07e-10 Systemic lupus erythematosus; LUSC cis rs11190604 1.000 rs10786598 chr10:102291579 G/A cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1775715 0.677 rs2808105 chr10:32110907 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.68e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg22166914 chr1:53195759 ZYG11B 0.68 11.41 0.53 1.08e-25 Monocyte count; LUSC cis rs4713675 0.505 rs753890 chr6:33652880 G/A cg14003231 chr6:33640908 ITPR3 0.33 6.16 0.32 2.04e-9 Plateletcrit; LUSC cis rs208520 0.690 rs207077 chr6:66769855 A/C cg07460842 chr6:66804631 NA -1.1 -16.62 -0.67 1.3e-45 Exhaled nitric oxide output; LUSC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2070488 0.775 rs2268762 chr3:38516075 A/G cg24069376 chr3:38537580 EXOG 0.41 7.95 0.4 2.89e-14 Electrocardiographic conduction measures; LUSC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg04155289 chr7:94953770 PON1 -0.36 -5.9 -0.31 9.16e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg17178900 chr1:205818956 PM20D1 0.9 17.07 0.68 2.11e-47 Menarche (age at onset); LUSC cis rs72960926 1.000 rs72969218 chr6:75042124 T/G cg03266952 chr6:74778945 NA -0.76 -6.4 -0.33 5.11e-10 Metabolite levels (MHPG); LUSC cis rs593982 0.920 rs72939198 chr11:65438079 G/A cg08755490 chr11:65554678 OVOL1 -1.56 -11.97 -0.55 1.06e-27 Atopic dermatitis; LUSC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.26 0.32 1.19e-9 Mean platelet volume; LUSC cis rs61990749 0.597 rs176952 chr14:78180736 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.59 6.45 0.33 3.85e-10 Fibroblast growth factor basic levels; LUSC cis rs2953174 0.786 rs8662 chr2:241517770 G/A cg07929629 chr2:241523174 NA 0.53 8.06 0.4 1.34e-14 Bipolar disorder; LUSC trans rs7824557 0.527 rs2572449 chr8:11239137 A/G cg06636001 chr8:8085503 FLJ10661 0.49 7.82 0.39 6.89e-14 Retinal vascular caliber; LUSC cis rs11997175 0.574 rs4389890 chr8:33658018 C/T ch.8.33884649F chr8:33765107 NA 0.55 9.44 0.46 6.83e-19 Body mass index; LUSC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg22823121 chr1:150693482 HORMAD1 0.5 7.44 0.38 8.47e-13 Melanoma; LUSC cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg26384229 chr12:38710491 ALG10B 0.96 18.5 0.71 4.06e-53 Heart rate; LUSC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.55e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12477438 0.765 rs2309454 chr2:99595418 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.68 -0.57 2.41e-30 Chronic sinus infection; LUSC cis rs2456568 0.548 rs10466334 chr11:93663512 A/G cg26875233 chr11:93583750 C11orf90 -0.31 -6.07 -0.32 3.45e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg18099408 chr3:52552593 STAB1 -0.43 -6.97 -0.36 1.7e-11 Bipolar disorder; LUSC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg01283332 chr5:1856932 NA -0.34 -6.46 -0.33 3.73e-10 Cardiovascular disease risk factors; LUSC cis rs611744 0.647 rs631775 chr8:109252746 T/C cg21045802 chr8:109455806 TTC35 0.42 6.51 0.34 2.78e-10 Dupuytren's disease; LUSC cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg11266682 chr4:10021025 SLC2A9 -0.45 -8.42 -0.42 1.09e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg24879335 chr3:133465180 TF 0.45 7.83 0.39 6.33e-14 Iron status biomarkers (transferrin levels); LUSC cis rs4285028 0.580 rs1523519 chr3:121631841 C/T cg11130432 chr3:121712080 ILDR1 -0.49 -8.15 -0.41 7.15e-15 Multiple sclerosis; LUSC cis rs11758351 0.789 rs4496782 chr6:26184617 T/C cg01420254 chr6:26195488 NA 0.48 5.94 0.31 7.2e-9 Gout;Renal underexcretion gout; LUSC cis rs7289126 0.966 rs5995554 chr22:38630272 T/C cg25457927 chr22:38595422 NA -0.29 -5.65 -0.3 3.53e-8 Mammographic density (dense area);Percent mammographic density; LUSC trans rs724744 0.804 rs1205940 chr6:22357113 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.05 -0.31 3.89e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10633931 chr6:34164263 NA 0.73 6.02 0.31 4.72e-9 Cognitive performance; LUSC cis rs7177699 0.557 rs3971829 chr15:79109052 A/G cg00540400 chr15:79124168 NA 0.46 7.91 0.4 3.85e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10789491 1.000 rs601060 chr1:47139580 C/G cg15501359 chr1:47185051 KIAA0494 -0.82 -11.43 -0.53 9.09e-26 Response to hepatitis C treatment; LUSC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg18827107 chr12:86230957 RASSF9 0.44 6.77 0.35 5.96e-11 Major depressive disorder; LUSC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg13722127 chr7:150037890 RARRES2 0.38 5.79 0.3 1.63e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg05985134 chr18:33552581 C18orf21 0.5 6.73 0.35 7.6e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.32 -0.33 8.49e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7824557 0.603 rs2250028 chr8:11213589 T/G cg27411982 chr8:10470053 RP1L1 0.44 6.62 0.34 1.47e-10 Retinal vascular caliber; LUSC cis rs2742417 1.000 rs2742373 chr3:45784046 C/G cg04837898 chr3:45731254 SACM1L -0.38 -6.33 -0.33 7.75e-10 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs55665837 1.000 rs12276938 chr11:14463488 C/G cg05501817 chr11:14380813 RRAS2 -0.4 -6.31 -0.33 8.87e-10 Vitamin D levels; LUSC trans rs2055729 0.736 rs11249965 chr8:9740863 C/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.43 -0.33 4.49e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs10465746 0.780 rs10874423 chr1:84374071 C/T cg10977910 chr1:84465055 TTLL7 0.44 6.23 0.32 1.42e-9 Obesity-related traits; LUSC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg09323728 chr8:95962352 TP53INP1 -0.3 -5.69 -0.3 2.78e-8 Type 2 diabetes; LUSC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg06028605 chr16:24865363 SLC5A11 -0.51 -8.98 -0.44 1.98e-17 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.31 -0.33 8.68e-10 Total body bone mineral density; LUSC cis rs738321 0.756 rs12169611 chr22:38513735 T/C cg25457927 chr22:38595422 NA -0.32 -6.11 -0.32 2.8e-9 Breast cancer; LUSC cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg23093090 chr10:104574429 C10orf26 -0.46 -8.34 -0.42 2.01e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs5758511 0.680 rs5758684 chr22:42649509 C/T cg00645731 chr22:42541494 CYP2D7P1 0.58 10.04 0.48 6.68e-21 Birth weight; LUSC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.09 0.61 1.02e-35 Platelet count; LUSC cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg12011299 chr4:100065546 ADH4 0.72 11.06 0.52 1.99e-24 Alcohol dependence; LUSC trans rs4714291 0.963 rs2475496 chr6:39963850 A/G cg02267698 chr19:7991119 CTXN1 0.5 7.04 0.36 1.13e-11 Strep throat; LUSC trans rs208520 0.690 rs207077 chr6:66769855 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -16.0 -0.66 3.67e-43 Exhaled nitric oxide output; LUSC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs12681288 0.550 rs72507624 chr8:961324 G/A cg04851639 chr8:1020857 NA -0.39 -7.84 -0.39 5.93e-14 Schizophrenia; LUSC cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.4 0.38 1.11e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs2625529 0.652 rs8027164 chr15:72407733 A/T cg16672083 chr15:72433130 SENP8 0.49 8.14 0.41 7.93e-15 Red blood cell count; LUSC cis rs9427116 0.502 rs12125166 chr1:154582129 A/G cg17218026 chr1:154582156 ADAR -0.5 -8.53 -0.42 5.25e-16 Blood protein levels; LUSC trans rs2898290 0.622 rs978803 chr8:11343475 C/T cg15556689 chr8:8085844 FLJ10661 0.54 8.74 0.43 1.14e-16 Systolic blood pressure; LUSC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg14019146 chr3:50243930 SLC38A3 0.32 7.09 0.36 7.92e-12 Intelligence (multi-trait analysis); LUSC cis rs62400317 0.859 rs17209678 chr6:45163601 C/T cg18551225 chr6:44695536 NA -0.45 -7.22 -0.37 3.47e-12 Total body bone mineral density; LUSC cis rs2307022 0.586 rs1562479 chr16:68387373 C/T cg02226672 chr16:68398533 SMPD3 0.3 5.82 0.3 1.42e-8 Body mass index; LUSC trans rs61931739 0.500 rs7977186 chr12:34431486 C/G cg13010199 chr12:38710504 ALG10B 0.69 10.88 0.51 8.56e-24 Morning vs. evening chronotype; LUSC cis rs7582720 1.000 rs72926769 chr2:203798318 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg26924012 chr15:45694286 SPATA5L1 1.12 19.49 0.73 4.86e-57 Homoarginine levels; LUSC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg21963583 chr11:68658836 MRPL21 0.55 8.45 0.42 9.37e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg00343986 chr7:65444356 GUSB 0.48 7.16 0.36 5.26e-12 Calcium levels; LUSC trans rs11098499 0.754 rs878376 chr4:120237702 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.51e-10 Corneal astigmatism; LUSC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg25019033 chr10:957182 NA -0.53 -6.1 -0.32 2.91e-9 Eosinophil percentage of granulocytes; LUSC cis rs7223966 1.000 rs11658175 chr17:61923838 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.77 0.35 5.8200000000000003e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs644799 0.562 rs669973 chr11:95571839 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.65 9.43 0.46 7.4e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2236918 0.687 rs2797600 chr1:242029331 C/T cg17736920 chr1:242011382 EXO1 0.42 6.61 0.34 1.52e-10 Menopause (age at onset); LUSC trans rs11148252 0.574 rs3742297 chr13:53278067 T/C cg18335740 chr13:41363409 SLC25A15 0.79 14.99 0.63 3.41e-39 Lewy body disease; LUSC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg13683864 chr3:40499215 RPL14 -1.13 -21.95 -0.77 9.5e-67 Renal cell carcinoma; LUSC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg22823121 chr1:150693482 HORMAD1 0.58 9.09 0.45 8.66e-18 Tonsillectomy; LUSC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.89 0.44 3.86e-17 Schizophrenia; LUSC trans rs11098499 0.697 rs10016448 chr4:120298845 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg12963246 chr6:28129442 ZNF389 0.54 7.61 0.38 2.73e-13 Depression; LUSC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg26354017 chr1:205819088 PM20D1 -0.42 -5.76 -0.3 1.9e-8 Parkinson's disease; LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13126279 chr21:47581558 C21orf56 -0.56 -8.67 -0.43 1.86e-16 Testicular germ cell tumor; LUSC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg05084668 chr3:125655381 ALG1L -0.49 -6.99 -0.36 1.49e-11 Blood pressure (smoking interaction); LUSC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg17279839 chr7:150038598 RARRES2 0.48 7.6 0.38 3.05e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs75804782 0.641 rs3769123 chr2:239349328 C/G cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs12410462 0.681 rs58496521 chr1:227582375 T/C cg10327440 chr1:227177885 CDC42BPA -0.6 -5.73 -0.3 2.28e-8 Major depressive disorder; LUSC cis rs1023500 0.573 rs8135801 chr22:42475568 A/G cg05082376 chr22:42548792 NA 0.43 6.47 0.33 3.4e-10 Schizophrenia; LUSC trans rs2243480 1.000 rs7778911 chr7:65694506 T/C cg10756647 chr7:56101905 PSPH -0.87 -8.68 -0.43 1.81e-16 Diabetic kidney disease; LUSC cis rs10197940 0.662 rs2432945 chr2:152278414 T/C cg06191203 chr2:152266755 RIF1 -0.52 -7.13 -0.36 6.27e-12 Lung cancer; LUSC cis rs7592578 0.766 rs62182885 chr2:191437024 A/G cg11845111 chr2:191398756 TMEM194B -0.89 -11.07 -0.52 1.83e-24 Diastolic blood pressure; LUSC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs926938 0.765 rs2268701 chr1:115233046 C/T cg12756093 chr1:115239321 AMPD1 -0.56 -8.86 -0.44 4.81e-17 Autism; LUSC cis rs926392 0.572 rs6129159 chr20:37675011 A/T cg16355469 chr20:37678765 NA 0.54 7.47 0.38 7.3e-13 Dialysis-related mortality; LUSC cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg17507749 chr15:85114479 UBE2QP1 0.58 7.38 0.37 1.3e-12 Schizophrenia; LUSC cis rs12971120 0.891 rs11151960 chr18:72177232 G/A cg25817165 chr18:72167213 CNDP2 -0.71 -8.37 -0.42 1.59e-15 Refractive error; LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 15.92 0.66 7.26e-43 Platelet count; LUSC cis rs1419980 0.673 rs7296837 chr12:7757832 A/G cg10578777 chr12:7781093 NA 0.57 6.31 0.33 8.68e-10 HDL cholesterol levels; LUSC cis rs9326248 0.581 rs6589582 chr11:116829200 A/C cg11861562 chr11:117069780 TAGLN 0.35 6.71 0.34 8.11e-11 Blood protein levels; LUSC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg06697600 chr4:7070879 GRPEL1 -0.39 -6.55 -0.34 2.24e-10 Monocyte percentage of white cells; LUSC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.4 0.53 1.16e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs3857536 0.813 rs6931701 chr6:66940905 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs7106204 0.514 rs7107321 chr11:24259879 T/C ch.11.24196551F chr11:24239977 NA 0.83 8.6 0.43 3.21e-16 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1003719 0.788 rs2835579 chr21:38457965 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.46 0.53 7.16e-26 Eye color traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04732910 chr12:69201696 MDM2 -0.46 -6.93 -0.35 2.23e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7903847 0.642 rs12359257 chr10:99136359 A/T cg08345082 chr10:99160200 RRP12 -0.41 -7.95 -0.4 2.99e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.87 0.35 3.09e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs4356932 0.967 rs7659236 chr4:76953611 T/C cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg26408565 chr15:76604113 ETFA -0.52 -8.41 -0.42 1.19e-15 Blood metabolite levels; LUSC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg02475777 chr4:1388615 CRIPAK 0.43 6.36 0.33 6.48e-10 Obesity-related traits; LUSC cis rs9467773 1.000 rs3736782 chr6:26505403 C/A cg09904177 chr6:26538194 HMGN4 0.73 13.27 0.59 1.45e-32 Intelligence (multi-trait analysis); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg18807929 chr2:217558075 IGFBP5 0.4 6.13 0.32 2.42e-9 N-glycan levels; LUSC cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg09184832 chr6:79620586 NA -0.44 -7.09 -0.36 8.12e-12 Intelligence (multi-trait analysis); LUSC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg01341218 chr17:43662625 NA 0.76 11.13 0.52 1.07e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs7786808 0.579 rs4045391 chr7:158181826 T/C cg02030672 chr11:45687055 CHST1 0.49 7.81 0.39 7.6e-14 Obesity-related traits; LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.62e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12681287 0.547 rs7459877 chr8:87505660 G/A cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs2730245 0.593 rs842699 chr7:158663404 T/A cg14689365 chr7:158441557 NCAPG2 0.51 7.4 0.38 1.13e-12 Height; LUSC cis rs10761482 0.954 rs10761475 chr10:62061257 T/C cg18175470 chr10:62150864 ANK3 -0.48 -6.56 -0.34 2.1e-10 Schizophrenia; LUSC trans rs1218582 0.772 rs12095061 chr1:154912968 A/T cg05839875 chr5:39203190 FYB -0.32 -6.03 -0.31 4.39e-9 Prostate cancer; LUSC cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg03517284 chr6:25882590 NA -0.52 -9.72 -0.47 7.59e-20 Blood metabolite levels; LUSC cis rs8060686 0.641 rs118035472 chr16:68242311 A/G cg05110241 chr16:68378359 PRMT7 -0.56 -6.32 -0.33 8.54e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg20887711 chr4:1340912 KIAA1530 0.43 6.67 0.34 1.07e-10 Obesity-related traits; LUSC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg14004847 chr7:1930337 MAD1L1 -0.53 -8.02 -0.4 1.76e-14 Bipolar disorder and schizophrenia; LUSC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.58 -0.42 3.61e-16 Neuroticism; LUSC cis rs698813 0.572 rs12712914 chr2:44478649 C/G cg00619915 chr2:44497795 NA -0.53 -7.6 -0.38 2.97e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12791010 chr2:190305806 WDR75 0.46 6.68 0.34 9.87e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12618769 0.597 rs3769730 chr2:99101453 T/C cg10123293 chr2:99228465 UNC50 0.47 7.67 0.39 1.89e-13 Bipolar disorder; LUSC cis rs4478858 0.735 rs1566964 chr1:31792794 C/A cg00250761 chr1:31883323 NA -0.35 -8.75 -0.43 1.09e-16 Alcohol dependence; LUSC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.39 0.56 2.97e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9479482 1.000 rs11754987 chr6:150351204 G/A cg00432049 chr6:150390894 ULBP3 -0.27 -5.74 -0.3 2.11e-8 Alopecia areata; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23979971 chr5:138677953 PAIP2 -0.53 -6.8 -0.35 4.7e-11 Bipolar disorder and schizophrenia; LUSC cis rs2835872 0.759 rs2835895 chr21:39066353 C/T cg20424643 chr21:39039972 KCNJ6 0.42 6.46 0.33 3.74e-10 Electroencephalographic traits in alcoholism; LUSC cis rs12586317 0.545 rs58342373 chr14:35395269 T/C cg16230307 chr14:35515116 FAM177A1 0.57 7.36 0.37 1.43e-12 Psoriasis; LUSC cis rs11758351 1.000 rs79264785 chr6:26194121 C/T cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC trans rs6601327 0.670 rs10092751 chr8:9426325 T/C cg15556689 chr8:8085844 FLJ10661 0.44 6.22 0.32 1.47e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs9467773 0.583 rs2498380 chr6:26643996 C/G cg05738196 chr6:26577821 NA -0.76 -14.67 -0.63 5.88e-38 Intelligence (multi-trait analysis); LUSC cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg08999081 chr20:33150536 PIGU -0.37 -6.83 -0.35 3.97e-11 Height; LUSC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg25258033 chr6:167368657 RNASET2 0.47 7.83 0.39 6.33e-14 Crohn's disease; LUSC cis rs10992471 0.603 rs10761160 chr9:95208701 A/T cg14631576 chr9:95140430 CENPP -0.35 -6.47 -0.33 3.54e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs2074585 0.647 rs2601188 chr15:90929563 A/G cg23497857 chr14:24685372 MDP1 -0.45 -7.05 -0.36 1.05e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.11 -0.32 2.77e-9 Major depressive disorder; LUSC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg13390004 chr1:15929781 NA 0.4 6.71 0.34 8.4e-11 Systolic blood pressure; LUSC cis rs6964587 0.872 rs57969083 chr7:91665627 A/T cg17063962 chr7:91808500 NA 0.58 9.31 0.45 1.69e-18 Breast cancer; LUSC cis rs8072100 0.817 rs11869940 chr17:45578435 T/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.34 5.71 0.3 2.54e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg05165339 chr4:1420672 NA 0.29 6.5 0.33 2.98e-10 Longevity; LUSC cis rs7937682 0.889 rs564086 chr11:111501079 C/G cg19812747 chr11:111475976 SIK2 -0.5 -7.05 -0.36 1.05e-11 Primary sclerosing cholangitis; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg02475777 chr4:1388615 CRIPAK 0.43 6.41 0.33 4.95e-10 Obesity-related traits; LUSC cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg10518543 chr12:38710700 ALG10B -0.4 -5.64 -0.3 3.53e-8 Morning vs. evening chronotype; LUSC cis rs782590 1.000 rs782590 chr2:55843413 C/T cg03859395 chr2:55845619 SMEK2 0.85 15.89 0.66 9.53e-43 Metabolic syndrome; LUSC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg21984481 chr17:79567631 NPLOC4 -0.54 -9.9 -0.48 1.96e-20 Eye color traits; LUSC cis rs11676348 0.935 rs13007992 chr2:218964051 G/T cg00012203 chr2:219082015 ARPC2 -0.54 -8.52 -0.42 5.65e-16 Ulcerative colitis; LUSC cis rs1577917 0.958 rs2100109 chr6:86544926 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.79 -0.35 5.2e-11 Response to antipsychotic treatment; LUSC trans rs7613875 0.641 rs6446194 chr3:50067298 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.83 -0.39 6.71e-14 Body mass index; LUSC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg21972741 chr5:435613 AHRR 0.36 6.86 0.35 3.25e-11 Cystic fibrosis severity; LUSC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg10909506 chr17:38081995 ORMDL3 0.33 5.87 0.31 1.02e-8 Self-reported allergy; LUSC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg23625390 chr15:77176239 SCAPER 0.51 7.83 0.39 6.53e-14 Blood metabolite levels; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14813579 chr19:2328694 SPPL2B;LSM7 0.35 6.31 0.33 8.84e-10 Asthma; LUSC cis rs926392 0.965 rs6129166 chr20:37688825 T/C cg27552599 chr20:37590471 DHX35 0.33 5.69 0.3 2.85e-8 Dialysis-related mortality; LUSC cis rs4665630 0.522 rs2551350 chr2:23913985 T/C cg08063864 chr2:24346004 PFN4;LOC375190 -0.88 -7.67 -0.39 1.92e-13 Hypertension; LUSC cis rs9325144 0.577 rs10876008 chr12:39126750 T/C cg26384229 chr12:38710491 ALG10B -0.61 -9.45 -0.46 6.27e-19 Morning vs. evening chronotype; LUSC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs4595586 0.525 rs17464772 chr12:39247777 G/A cg13010199 chr12:38710504 ALG10B 0.62 9.02 0.44 1.49e-17 Morning vs. evening chronotype; LUSC cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg08999081 chr20:33150536 PIGU -0.42 -7.7 -0.39 1.53e-13 Glomerular filtration rate (creatinine); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11728497 chr12:12871887 CDKN1B -0.43 -6.06 -0.31 3.74e-9 Hepatitis; LUSC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg11812906 chr14:75593930 NEK9 0.65 11.14 0.52 1.03e-24 Height; LUSC cis rs6840360 0.653 rs13136369 chr4:152731283 T/G cg22705602 chr4:152727874 NA 0.28 5.92 0.31 7.79e-9 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg09177884 chr7:1199841 ZFAND2A -0.43 -6.19 -0.32 1.75e-9 Longevity;Endometriosis; LUSC trans rs7615952 0.576 rs6780025 chr3:125815624 A/C cg07211511 chr3:129823064 LOC729375 -0.75 -9.75 -0.47 6.42e-20 Blood pressure (smoking interaction); LUSC trans rs11098499 0.909 rs79704848 chr4:120309351 T/A cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 16.09 0.66 1.53e-43 Platelet count; LUSC cis rs7605378 1.000 rs769957 chr2:200695524 A/C cg17644776 chr2:200775616 C2orf69 0.38 6.07 0.32 3.5e-9 Osteoporosis; LUSC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.67 10.69 0.5 3.99e-23 Body mass index (adult); LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg02951883 chr7:2050386 MAD1L1 -0.4 -6.86 -0.35 3.34e-11 Bipolar disorder and schizophrenia; LUSC cis rs9646944 0.501 rs2075186 chr2:103057251 G/T cg20060108 chr2:102954350 IL1RL1 0.47 6.56 0.34 2.08e-10 Blood protein levels; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.42 0.42 1.16e-15 Prudent dietary pattern; LUSC cis rs887829 0.569 rs4294999 chr2:234635467 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.83 -0.39 6.48e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.47 0.38 6.85e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg18681998 chr4:17616180 MED28 -0.79 -14.52 -0.62 2.28e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19233923 chr11:63753598 OTUB1 0.36 6.33 0.33 7.75e-10 Triglycerides; LUSC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg26566898 chr11:117069891 TAGLN 0.47 8.45 0.42 9.18e-16 Blood protein levels; LUSC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.95 -0.31 6.92e-9 Intelligence (multi-trait analysis); LUSC trans rs12458462 0.859 rs2242177 chr18:77477379 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.48 -6.83 -0.35 4.12e-11 Monocyte count; LUSC cis rs6424115 0.830 rs6672157 chr1:24198840 C/G cg10978503 chr1:24200527 CNR2 0.53 13.1 0.58 6.34e-32 Immature fraction of reticulocytes; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg11062466 chr8:58055876 NA 0.75 9.12 0.45 7.24e-18 Developmental language disorder (linguistic errors); LUSC cis rs6728642 0.572 rs2872686 chr2:97601024 A/G cg26665480 chr2:98280029 ACTR1B -0.76 -7.62 -0.38 2.67e-13 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg22862634 chr11:62369728 EML3;MTA2 0.5 7.19 0.37 4.32e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9287719 0.967 rs3814388 chr2:10702099 A/T cg03983476 chr2:10830698 NOL10 -0.37 -5.69 -0.3 2.71e-8 Prostate cancer; LUSC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg04455712 chr21:45112962 RRP1B 0.45 8.53 0.42 5.06e-16 Mean corpuscular volume; LUSC cis rs11250098 0.503 rs7821826 chr8:10769439 C/T cg27411982 chr8:10470053 RP1L1 -0.46 -6.76 -0.35 5.99e-11 Morning vs. evening chronotype; LUSC cis rs1014246 0.541 rs887195 chr10:118507976 G/A cg14919929 chr10:118506882 NA -0.49 -7.97 -0.4 2.55e-14 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs3857536 0.813 rs7757118 chr6:66946661 T/C cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC trans rs747782 0.527 rs2279822 chr11:48146114 C/T cg15704280 chr7:45808275 SEPT13 0.71 6.42 0.33 4.6e-10 Intraocular pressure; LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.9 0.31 9.03e-9 Menopause (age at onset); LUSC cis rs4380275 1.000 rs73143802 chr2:773826 T/C cg21665850 chr2:731073 NA 0.42 6.75 0.35 6.49e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs10504073 0.647 rs4873314 chr8:50011656 A/C cg00325661 chr8:49890786 NA 0.62 9.95 0.48 1.38e-20 Blood metabolite ratios; LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.04 0.61 1.63e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1335645 0.570 rs61804624 chr1:111653917 A/G cg00321911 chr1:111669324 DRAM2 -0.68 -6.9 -0.35 2.64e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg21226059 chr5:178986404 RUFY1 -0.64 -11.24 -0.52 4.46e-25 Lung cancer; LUSC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11644478 chr21:40555479 PSMG1 -0.59 -9.3 -0.45 1.91e-18 Menarche (age at onset); LUSC cis rs6005807 0.719 rs6005809 chr22:28942227 C/T cg12565055 chr22:29076175 TTC28 -0.54 -5.69 -0.3 2.81e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2073300 0.609 rs3736755 chr20:23377642 C/T cg12062639 chr20:23401060 NAPB 0.87 7.92 0.4 3.64e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg21724239 chr8:58056113 NA 0.58 7.15 0.36 5.42e-12 Developmental language disorder (linguistic errors); LUSC cis rs6940638 0.956 rs12199218 chr6:27025281 T/C cg09904177 chr6:26538194 HMGN4 -0.48 -5.86 -0.31 1.13e-8 Intelligence (multi-trait analysis); LUSC cis rs1639906 0.507 rs1004643 chr7:2185324 G/C cg22963979 chr7:1858916 MAD1L1 0.46 6.11 0.32 2.7e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 0.867 rs16957630 chr15:43642780 A/T cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg01849466 chr14:104193079 ZFYVE21 0.54 8.25 0.41 3.62e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs12541635 0.677 rs6999580 chr8:107018254 C/T cg10147462 chr8:107024639 NA 0.67 14.04 0.61 1.56e-35 Age of smoking initiation; LUSC cis rs61931739 0.500 rs7965421 chr12:34523624 G/T cg06521331 chr12:34319734 NA -0.42 -6.46 -0.33 3.61e-10 Morning vs. evening chronotype; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg24675658 chr1:53192096 ZYG11B -0.62 -10.24 -0.49 1.4e-21 Monocyte count; LUSC cis rs600231 0.623 rs3015966 chr11:65217589 T/C cg17120908 chr11:65337727 SSSCA1 -0.53 -9.16 -0.45 5.48e-18 Bone mineral density; LUSC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg21960279 chr19:17905606 B3GNT3 0.38 5.99 0.31 5.49e-9 Tumor biomarkers; LUSC cis rs7659604 0.540 rs4075065 chr4:122683906 A/G cg20573242 chr4:122745356 CCNA2 -0.38 -5.79 -0.3 1.64e-8 Type 2 diabetes; LUSC cis rs2067615 0.579 rs10861665 chr12:107193836 T/C cg15890332 chr12:107067104 RFX4 0.34 6.18 0.32 1.91e-9 Heart rate; LUSC cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg08807101 chr21:30365312 RNF160 -0.69 -11.93 -0.55 1.44e-27 Dental caries; LUSC trans rs1814175 0.765 rs1722003 chr11:49895896 G/A cg15704280 chr7:45808275 SEPT13 -1.13 -24.89 -0.81 4.3e-78 Height; LUSC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg19346786 chr7:2764209 NA -0.39 -6.54 -0.34 2.37e-10 Height; LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg20503657 chr10:835505 NA 0.73 8.71 0.43 1.41e-16 Eosinophil percentage of granulocytes; LUSC cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg18132916 chr6:79620363 NA -0.38 -5.77 -0.3 1.8e-8 Intelligence (multi-trait analysis); LUSC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg11764359 chr7:65958608 NA -0.81 -13.49 -0.59 2.12e-33 Aortic root size; LUSC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg03354898 chr7:1950403 MAD1L1 -0.31 -5.89 -0.31 9.34e-9 Bipolar disorder and schizophrenia; LUSC cis rs55910451 0.549 rs72772355 chr10:5813473 C/T cg11519256 chr10:5708881 ASB13 -0.51 -6.29 -0.33 1.01e-9 Breast cancer; LUSC cis rs6424115 0.800 rs6665733 chr1:24200158 T/C cg10978503 chr1:24200527 CNR2 0.54 13.24 0.59 1.85e-32 Immature fraction of reticulocytes; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09154213 chr1:25756855 TMEM57 -0.38 -5.97 -0.31 5.98e-9 Electrocardiographic conduction measures; LUSC cis rs7208859 0.623 rs9916727 chr17:29107472 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg02503808 chr4:7069936 GRPEL1 0.98 14.21 0.61 3.67e-36 Monocyte percentage of white cells; LUSC cis rs9902453 0.845 rs2628165 chr17:28121166 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.82 0.43 6.43e-17 Coffee consumption (cups per day); LUSC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg26441486 chr22:50317300 CRELD2 0.49 7.46 0.38 7.33e-13 Schizophrenia; LUSC cis rs372883 0.901 rs8133749 chr21:30615935 C/T cg24692254 chr21:30365293 RNF160 -0.41 -5.72 -0.3 2.31e-8 Pancreatic cancer; LUSC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg23711669 chr6:146136114 FBXO30 -0.9 -16.98 -0.68 4.7e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs2235649 0.798 rs9932875 chr16:1848012 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.02 -0.31 4.48e-9 Blood metabolite levels; LUSC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg18190219 chr22:46762943 CELSR1 -0.48 -5.94 -0.31 7.32e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs1799949 0.602 rs8176199 chr17:41230524 T/G cg25288140 chr17:41278341 BRCA1;NBR2 0.45 6.07 0.31 3.56e-9 Menopause (age at onset); LUSC cis rs868036 1.000 rs1026732 chr15:68095085 C/T cg05925327 chr15:68127851 NA -0.32 -5.75 -0.3 2.05e-8 Restless legs syndrome; LUSC cis rs11690935 0.632 rs12998411 chr2:172530707 G/C cg13550731 chr2:172543902 DYNC1I2 0.59 9.42 0.46 7.79e-19 Schizophrenia; LUSC cis rs9611565 0.592 rs12484467 chr22:41957610 T/C cg17554472 chr22:41940697 POLR3H -0.47 -5.73 -0.3 2.26e-8 Vitiligo; LUSC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg27165867 chr14:105738592 BRF1 -0.53 -7.81 -0.39 7.53e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg23985595 chr17:80112537 CCDC57 0.31 5.97 0.31 6.13e-9 Life satisfaction; LUSC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg09455208 chr3:40491958 NA 0.59 10.38 0.49 4.46e-22 Renal cell carcinoma; LUSC cis rs1982963 0.627 rs61971552 chr14:52481524 G/T cg10843707 chr14:52510701 NID2 0.42 5.9 0.31 8.96e-9 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27574256 chr1:52607756 ZFYVE9 -0.4 -6.07 -0.32 3.53e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6762 0.748 rs3059 chr11:840319 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.9 -0.35 2.63e-11 Mean platelet volume; LUSC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg06671706 chr8:8559999 CLDN23 0.48 6.58 0.34 1.82e-10 Obesity-related traits; LUSC cis rs59698941 0.882 rs66537260 chr5:132309237 C/T cg02081065 chr5:132209139 LEAP2 -0.61 -5.87 -0.31 1.03e-8 Apolipoprotein A-IV levels; LUSC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg05110241 chr16:68378359 PRMT7 -0.57 -6.59 -0.34 1.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.33 0.49 6.71e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9303401 0.625 rs10515159 chr17:56802693 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs2070433 0.752 rs11700468 chr21:47776391 C/T cg12379764 chr21:47803548 PCNT 0.75 9.31 0.45 1.8e-18 Lymphocyte counts; LUSC cis rs2486288 0.656 rs8039540 chr15:45551842 C/G cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.67 -0.5 4.42e-23 Glomerular filtration rate; LUSC cis rs4812048 0.649 rs6070705 chr20:57625231 A/C cg14073986 chr20:57617431 SLMO2 0.88 9.5 0.46 4.16e-19 Mean platelet volume; LUSC cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg03605463 chr16:89740564 NA 0.45 7.17 0.37 4.97e-12 Vitiligo; LUSC cis rs3087591 1.000 rs2525578 chr17:29711411 A/G cg24425628 chr17:29625626 OMG;NF1 -0.58 -8.35 -0.42 1.84e-15 Hip circumference; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg11905131 chr22:24372483 LOC391322 -0.6 -10.29 -0.49 9.14e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg25554036 chr4:6271136 WFS1 0.61 12.65 0.57 3.12e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs61931739 0.500 rs10844863 chr12:34532284 C/T cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg00330888 chr2:46524148 EPAS1 0.37 6.41 0.33 5.07e-10 Metabolite levels (Pyroglutamine); LUSC cis rs113835537 0.529 rs3741360 chr11:66300348 A/G cg24851651 chr11:66362959 CCS 0.55 7.97 0.4 2.62e-14 Airway imaging phenotypes; LUSC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg15448220 chr1:150897856 SETDB1 0.43 6.23 0.32 1.43e-9 Melanoma; LUSC trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg15704280 chr7:45808275 SEPT13 -0.46 -6.29 -0.33 1e-9 HDL cholesterol; LUSC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6964587 1.000 rs9690778 chr7:91735299 A/G cg17063962 chr7:91808500 NA 0.6 9.36 0.46 1.17e-18 Breast cancer; LUSC cis rs12900413 0.687 rs28475471 chr15:90311749 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.85 -0.3 1.17e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs4919087 1.000 rs10786333 chr10:99090390 A/G cg25902810 chr10:99078978 FRAT1 -0.46 -6.66 -0.34 1.15e-10 Monocyte count; LUSC cis rs6762 0.748 rs7928935 chr11:839127 G/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.61 -0.34 1.48e-10 Mean platelet volume; LUSC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.68 0.39 1.79e-13 Lung function (FEV1/FVC); LUSC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06022373 chr22:39101656 GTPBP1 0.71 11.56 0.53 3.23e-26 Menopause (age at onset); LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg08888203 chr3:10149979 C3orf24 0.6 8.26 0.41 3.39e-15 Alzheimer's disease; LUSC cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg00339695 chr16:24857497 SLC5A11 -0.41 -7.19 -0.37 4.38e-12 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.530 rs11072614 chr15:76967205 G/A cg23625390 chr15:77176239 SCAPER -0.62 -9.14 -0.45 6.04e-18 Blood metabolite levels; LUSC cis rs4805272 0.539 rs7256211 chr19:29333063 C/G cg04546413 chr19:29218101 NA 0.57 7.4 0.38 1.12e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs11700980 0.551 rs2832031 chr21:30114680 T/C cg14791747 chr16:20752902 THUMPD1 0.55 5.99 0.31 5.36e-9 QRS complex (12-leadsum); LUSC cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg17366294 chr4:99064904 C4orf37 -0.58 -10.36 -0.49 5.23e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs6138458 0.828 rs6138466 chr20:24997137 A/G cg26195577 chr20:24973756 C20orf3 0.81 12.42 0.56 2.2e-29 Blood protein levels; LUSC cis rs7605827 0.866 rs35237017 chr2:15615704 T/C cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.36e-16 Educational attainment (years of education); LUSC cis rs6987853 0.787 rs2974358 chr8:42434403 T/C cg09913449 chr8:42400586 C8orf40 0.5 8.52 0.42 5.4e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg22823121 chr1:150693482 HORMAD1 0.49 7.18 0.37 4.44e-12 Melanoma; LUSC cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg14844989 chr11:31128820 NA -0.37 -5.79 -0.3 1.67e-8 Red blood cell count; LUSC cis rs3733418 0.929 rs17623445 chr4:165894658 C/T cg25904183 chr4:165877875 C4orf39;TRIM61 -0.43 -5.87 -0.31 1.04e-8 Obesity-related traits; LUSC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg20203395 chr5:56204925 C5orf35 -0.75 -10.3 -0.49 8.8e-22 Initial pursuit acceleration; LUSC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg02569458 chr12:86230093 RASSF9 0.54 8.82 0.43 6.7e-17 Major depressive disorder; LUSC trans rs1325195 0.920 rs2816213 chr1:179183766 T/C cg11624085 chr17:8464688 MYH10 0.41 6.62 0.34 1.41e-10 IgE grass sensitization; LUSC trans rs2262909 0.962 rs411020 chr19:22231102 G/A cg05197062 chr11:11642011 GALNTL4 -0.56 -7.81 -0.39 7.34e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs1971762 0.523 rs3852562 chr12:54085750 T/C cg23533419 chr12:54090519 NA -0.37 -6.1 -0.32 2.94e-9 Height; LUSC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg06022373 chr22:39101656 GTPBP1 0.79 12.3 0.56 6.14e-29 Menopause (age at onset); LUSC trans rs11098499 0.955 rs11944880 chr4:120159334 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.44 -6.16 -0.32 2.1e-9 Corneal astigmatism; LUSC trans rs9650657 0.504 rs10093053 chr8:11037187 T/C cg15556689 chr8:8085844 FLJ10661 -0.56 -8.41 -0.42 1.21e-15 Neuroticism; LUSC cis rs12519773 0.967 rs1496331 chr5:92445784 G/T cg18783429 chr5:92414398 NA 0.27 5.94 0.31 7.35e-9 Migraine; LUSC cis rs3806843 0.966 rs2563261 chr5:140137713 G/T cg19875535 chr5:140030758 IK -0.45 -7.28 -0.37 2.4e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs61931739 0.857 rs419112 chr12:34130528 A/G cg06521331 chr12:34319734 NA -0.37 -6.34 -0.33 7.53e-10 Morning vs. evening chronotype; LUSC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg11663144 chr21:46675770 NA -0.41 -7.12 -0.36 6.7e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg08948841 chr4:1244042 CTBP1;C4orf42 0.32 6.25 0.32 1.22e-9 Obesity-related traits; LUSC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg09034736 chr1:150693464 HORMAD1 0.48 7.01 0.36 1.33e-11 Melanoma; LUSC cis rs16854884 0.657 rs920159 chr3:143753194 A/T cg06585982 chr3:143692056 C3orf58 0.5 7.91 0.4 3.89e-14 Economic and political preferences (feminism/equality); LUSC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg05855489 chr10:104503620 C10orf26 0.61 8.01 0.4 1.97e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg24296786 chr1:45957014 TESK2 0.46 6.63 0.34 1.38e-10 High light scatter reticulocyte count; LUSC trans rs629535 0.821 rs497398 chr8:70037434 A/T cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg19346786 chr7:2764209 NA -0.45 -7.63 -0.39 2.49e-13 Height; LUSC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -5.75 -0.3 1.99e-8 Total body bone mineral density; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg07157834 chr1:205819609 PM20D1 -0.85 -15.28 -0.64 2.53e-40 Menarche (age at onset); LUSC cis rs10761482 0.861 rs2061490 chr10:62103662 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs7071206 0.853 rs114936111 chr10:79430143 G/A cg07817648 chr10:79422355 NA -0.45 -6.3 -0.33 9.53e-10 Bone mineral density; LUSC cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg00071950 chr4:10020882 SLC2A9 0.58 9.89 0.48 2.08e-20 Bone mineral density; LUSC trans rs11098499 0.863 rs3775854 chr4:120471971 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs75804782 0.641 rs56000747 chr2:239318541 T/G cg18131467 chr2:239335373 ASB1 -0.74 -6.59 -0.34 1.67e-10 Morning vs. evening chronotype;Chronotype; LUSC trans rs7618501 0.633 rs11130228 chr3:50003246 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.07 0.44 1.02e-17 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.659 rs34382037 chr17:56643550 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC cis rs6840360 0.870 rs7680604 chr4:152469917 C/T cg22705602 chr4:152727874 NA -0.3 -6.27 -0.32 1.12e-9 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.539 rs11250131 chr8:11251175 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.59 -0.34 1.76e-10 Triglycerides; LUSC cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg26597838 chr10:835615 NA -0.48 -6.53 -0.34 2.45e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs500891 0.547 rs34533621 chr6:84069099 C/T cg08257003 chr6:84140564 ME1 0.32 7.34 0.37 1.61e-12 Platelet-derived growth factor BB levels; LUSC cis rs72634258 0.786 rs9434991 chr1:8178708 G/C cg26816564 chr1:7831052 VAMP3 0.47 6.17 0.32 1.99e-9 Inflammatory bowel disease; LUSC cis rs834811 0.505 rs7789711 chr7:135938979 C/T cg01726295 chr7:135938950 NA -0.41 -7.43 -0.38 9.16e-13 Post-traumatic stress disorder; LUSC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.61e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg18876405 chr7:65276391 NA -0.55 -8.93 -0.44 2.85e-17 Aortic root size; LUSC cis rs10782582 0.593 rs11163915 chr1:76130199 C/T cg22875332 chr1:76189707 ACADM -0.42 -6.25 -0.32 1.26e-9 Daytime sleep phenotypes; LUSC cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg00071950 chr4:10020882 SLC2A9 -0.48 -8.03 -0.4 1.69e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7168353 0.519 rs11074140 chr15:93635244 C/G cg02918577 chr15:93633145 RGMA -0.33 -6.22 -0.32 1.52e-9 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs59698941 0.943 rs12520928 chr5:132305891 C/A cg02081065 chr5:132209139 LEAP2 -0.59 -5.89 -0.31 9.68e-9 Apolipoprotein A-IV levels; LUSC cis rs854765 0.583 rs9904163 chr17:17830553 C/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.43 -0.42 1.03e-15 Total body bone mineral density; LUSC cis rs950776 0.518 rs1979907 chr15:78842239 T/C cg06917634 chr15:78832804 PSMA4 -0.81 -14.28 -0.62 1.92e-36 Sudden cardiac arrest; LUSC cis rs9430161 0.579 rs10864486 chr1:11040979 A/G cg02454025 chr1:11042201 C1orf127 0.93 17.26 0.69 3.66e-48 Ewing sarcoma; LUSC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.48e-24 Aortic root size; LUSC trans rs853679 1.000 rs2799077 chr6:28234597 C/T cg01620082 chr3:125678407 NA -0.54 -6.38 -0.33 5.89e-10 Depression; LUSC cis rs1113500 0.933 rs11185260 chr1:108635079 A/T cg11967332 chr1:108735228 SLC25A24 -0.42 -6.35 -0.33 6.98e-10 Growth-regulated protein alpha levels; LUSC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7617773 0.817 rs9837228 chr3:48324466 A/T cg11946769 chr3:48343235 NME6 -0.86 -14.17 -0.61 5.27e-36 Coronary artery disease; LUSC cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs3750965 0.959 rs11228490 chr11:68860872 C/G cg06818126 chr11:68850279 TPCN2 0.44 6.57 0.34 1.92e-10 Hair color; LUSC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg03806693 chr22:41940476 POLR3H -1.04 -14.38 -0.62 7.95e-37 Vitiligo; LUSC cis rs11971779 0.680 rs4732376 chr7:139098024 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs11864453 0.762 rs6416742 chr16:72149061 C/T cg01557791 chr16:72042693 DHODH -0.54 -7.61 -0.38 2.87e-13 Fibrinogen levels; LUSC cis rs2486288 0.656 rs12908818 chr15:45571668 A/G cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.77 -0.39 9.67e-14 Glomerular filtration rate; LUSC cis rs7605827 0.930 rs13019216 chr2:15659539 A/G cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs11148252 0.514 rs9526843 chr13:52730056 C/T cg00495681 chr13:53174319 NA 0.41 5.97 0.31 6.04e-9 Lewy body disease; LUSC cis rs7212590 0.655 rs16943969 chr17:58031153 A/G cg10252138 chr17:58120427 NA -0.8 -7.53 -0.38 4.68e-13 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs9916302 0.706 rs7208487 chr17:37543449 T/G cg07936489 chr17:37558343 FBXL20 0.8 9.91 0.48 1.86e-20 Glomerular filtration rate (creatinine); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20738406 chr15:90233884 WDR93;PEX11A -0.48 -6.16 -0.32 2.08e-9 Hepatitis; LUSC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs7520050 0.807 rs28647556 chr1:46206399 G/A cg06784218 chr1:46089804 CCDC17 0.3 5.95 0.31 6.92e-9 Red blood cell count;Reticulocyte count; LUSC cis rs7481584 0.624 rs511990 chr11:3052936 A/G cg05729581 chr11:3078854 CARS 0.4 5.77 0.3 1.82e-8 Calcium levels; LUSC cis rs6840360 0.571 rs4696274 chr4:152528478 C/A cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.66e-10 Intelligence (multi-trait analysis); LUSC cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg11058730 chr11:34937778 PDHX;APIP 0.69 11.08 0.52 1.61e-24 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg22535103 chr8:58192502 C8orf71 -0.61 -7.13 -0.36 6.28e-12 Developmental language disorder (linguistic errors); LUSC cis rs9527 0.590 rs7087040 chr10:104799668 G/A cg05855489 chr10:104503620 C10orf26 0.53 8.09 0.4 1.13e-14 Arsenic metabolism; LUSC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg26116260 chr4:7069785 GRPEL1 0.92 11.82 0.54 3.53e-27 Monocyte percentage of white cells; LUSC cis rs9359856 0.564 rs17735590 chr6:90330268 G/C cg13799429 chr6:90582589 CASP8AP2 -0.82 -7.91 -0.4 3.71e-14 Bipolar disorder; LUSC cis rs757081 0.667 rs12420958 chr11:17100432 G/T cg15432903 chr11:17409602 KCNJ11 -0.39 -6.04 -0.31 4e-9 Systolic blood pressure; LUSC cis rs7843479 0.601 rs4872207 chr8:21842751 C/G cg17168535 chr8:21777572 XPO7 -0.78 -14.39 -0.62 7.36e-37 Mean corpuscular volume; LUSC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.69e-9 Aortic root size; LUSC cis rs1107366 0.722 rs750714 chr3:125904688 G/A cg08481491 chr3:125900108 ALDH1L1 -0.29 -5.73 -0.3 2.3e-8 Metabolite levels; LUSC trans rs1005277 0.540 rs4934907 chr10:38015230 A/C cg17830980 chr10:43048298 ZNF37B -0.4 -6.33 -0.33 7.81e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC cis rs1775715 0.707 rs1541261 chr10:32179523 G/A cg26784012 chr10:32216390 ARHGAP12 0.47 7.91 0.4 3.92e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6693567 0.565 rs1260408 chr1:150307270 T/G cg15654264 chr1:150340011 RPRD2 0.46 7.36 0.37 1.46e-12 Migraine; LUSC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg00049323 chr5:472564 LOC25845 -0.41 -6.44 -0.33 4.11e-10 Cystic fibrosis severity; LUSC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg04944784 chr2:26401820 FAM59B -0.75 -10.33 -0.49 7.09e-22 Gut microbiome composition (summer); LUSC cis rs4409675 0.576 rs7535816 chr1:28234054 A/G cg23691781 chr1:28212827 C1orf38 0.33 7.8 0.39 7.87e-14 Corneal astigmatism; LUSC cis rs950776 0.518 rs952215 chr15:78819153 C/T cg22563815 chr15:78856949 CHRNA5 -0.27 -6.4 -0.33 5.2400000000000005e-10 Sudden cardiac arrest; LUSC cis rs1949733 0.701 rs1880024 chr4:8454639 A/G cg13073564 chr4:8508604 NA -0.45 -8.31 -0.41 2.46e-15 Response to antineoplastic agents; LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.02 -15.13 -0.64 9.69e-40 Gut microbiome composition (summer); LUSC cis rs7246657 0.943 rs7408563 chr19:37808585 G/C cg23950597 chr19:37808831 NA -0.63 -7.58 -0.38 3.49e-13 Coronary artery calcification; LUSC cis rs1355223 1.000 rs35365094 chr11:34767790 A/C cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.84 -0.3 1.23e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 15.26 0.64 2.99e-40 Platelet count; LUSC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.27 -0.32 1.1e-9 Extrinsic epigenetic age acceleration; LUSC cis rs778371 0.723 rs6710294 chr2:233579634 T/C cg08000102 chr2:233561755 GIGYF2 0.82 14.1 0.61 9.27e-36 Schizophrenia; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg18538332 chr22:24372958 LOC391322 -0.49 -8.74 -0.43 1.12e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg16007573 chr7:152373310 XRCC2 0.47 6.06 0.31 3.67e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7223966 0.961 rs112709843 chr17:61836936 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.96 0.36 1.78e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.77 -12.44 -0.56 1.82e-29 Colorectal cancer; LUSC cis rs11209185 0.509 rs9326077 chr1:68452192 A/G cg22082780 chr1:68452167 NA 0.46 8.39 0.42 1.42e-15 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9921222 0.500 rs11648673 chr16:377794 G/A cg00101154 chr16:420108 MRPL28 -0.45 -6.76 -0.35 6.11e-11 Bone mineral density (spine);Bone mineral density; LUSC trans rs1941687 0.797 rs12967889 chr18:31399371 G/A cg27147174 chr7:100797783 AP1S1 -0.47 -6.87 -0.35 3.06e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs2932538 0.922 rs12739994 chr1:113131159 T/C cg22162597 chr1:113214053 CAPZA1 0.71 9.93 0.48 1.55e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs57920188 0.584 rs12080516 chr1:4089613 C/T cg20703997 chr1:4087676 NA 0.53 8.12 0.41 9.14e-15 Interleukin-17 levels; LUSC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 8.35 0.42 1.82e-15 Mean platelet volume; LUSC cis rs6964587 1.000 rs10228334 chr7:91713972 C/T cg17063962 chr7:91808500 NA 0.58 9.15 0.45 5.95e-18 Breast cancer; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14021555 chr22:43485536 TTLL1 0.41 6.1 0.32 2.99e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg00033643 chr7:134001901 SLC35B4 0.45 6.91 0.35 2.52e-11 Mean platelet volume; LUSC cis rs9300255 0.516 rs6488868 chr12:123799974 A/G cg13010344 chr12:123464640 ARL6IP4 -0.5 -7.3 -0.37 2.15e-12 Neutrophil percentage of white cells; LUSC trans rs61931739 0.517 rs7975714 chr12:34055611 T/C cg13010199 chr12:38710504 ALG10B 0.55 8.38 0.42 1.44e-15 Morning vs. evening chronotype; LUSC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.46e-10 Total body bone mineral density; LUSC cis rs2594714 1.000 rs12162265 chr19:13955161 G/A cg18576835 chr19:13944261 NA -0.42 -5.99 -0.31 5.47e-9 Breast cancer; LUSC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg03354898 chr7:1950403 MAD1L1 -0.35 -6.79 -0.35 5.09e-11 Schizophrenia; LUSC cis rs7568458 0.846 rs2028900 chr2:85767735 A/G cg23752985 chr2:85803571 VAMP8 -0.33 -7.02 -0.36 1.23e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg18876405 chr7:65276391 NA -0.56 -8.82 -0.43 6.67e-17 Aortic root size; LUSC trans rs10435719 0.902 rs12681142 chr8:11802601 T/C cg06636001 chr8:8085503 FLJ10661 0.53 7.92 0.4 3.64e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg09509183 chr1:209979624 IRF6 0.54 6.26 0.32 1.21e-9 Cleft lip with or without cleft palate; LUSC cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs3935685 0.934 rs11072664 chr15:77999859 C/G cg25212270 chr15:78015279 NA 0.29 6.38 0.33 5.98e-10 Intelligence (multi-trait analysis); LUSC cis rs4474465 1.000 rs57042969 chr11:78160120 C/T cg27205649 chr11:78285834 NARS2 -0.5 -5.94 -0.31 7.16e-9 Alzheimer's disease (survival time); LUSC cis rs2502731 0.539 rs3003610 chr9:130985525 G/A cg13642260 chr9:130955380 CIZ1 0.47 7.61 0.38 2.82e-13 Attention deficit hyperactivity disorder; LUSC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs722599 0.683 rs8022046 chr14:75278302 G/A cg06637938 chr14:75390232 RPS6KL1 0.4 5.67 0.3 3.02e-8 IgG glycosylation; LUSC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.54 -0.38 4.51e-13 Aortic root size; LUSC cis rs4319547 0.688 rs10744287 chr12:123077485 T/A cg05707623 chr12:122985044 ZCCHC8 -0.45 -6.19 -0.32 1.74e-9 Body mass index; LUSC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg27432699 chr2:27873401 GPN1 -0.57 -8.48 -0.42 7.28e-16 Total body bone mineral density; LUSC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg25019033 chr10:957182 NA -0.49 -6.15 -0.32 2.16e-9 Eosinophil percentage of granulocytes; LUSC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.47 -7.19 -0.37 4.34e-12 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.01e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.46e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7909074 0.832 rs10793564 chr10:45386352 C/A cg05187965 chr10:45406764 TMEM72 -0.36 -8.4 -0.42 1.33e-15 Mean corpuscular volume; LUSC cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg05283184 chr6:79620031 NA -0.56 -11.88 -0.54 2.27e-27 Intelligence (multi-trait analysis); LUSC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg19052272 chr2:3704530 ALLC -0.46 -7.61 -0.38 2.76e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg13010199 chr12:38710504 ALG10B 0.64 9.99 0.48 9.72e-21 Bladder cancer; LUSC cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.75 0.39 1.13e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg15448220 chr1:150897856 SETDB1 0.4 5.83 0.3 1.29e-8 Melanoma; LUSC cis rs12908161 0.853 rs12912342 chr15:85248216 T/C cg17507749 chr15:85114479 UBE2QP1 0.48 6.37 0.33 6.12e-10 Schizophrenia; LUSC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg10792982 chr14:105748885 BRF1 0.48 8.75 0.43 1.09e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg00431813 chr7:1051703 C7orf50 -0.47 -8.13 -0.41 8.72e-15 Longevity;Endometriosis; LUSC cis rs6429082 0.967 rs834143 chr1:235626406 C/T cg26050004 chr1:235667680 B3GALNT2 0.42 6.07 0.32 3.49e-9 Adiposity; LUSC cis rs4589502 1.000 rs16950284 chr15:67154184 A/G cg12317470 chr15:67143691 NA -0.63 -6.06 -0.31 3.6e-9 Lung cancer (smoking interaction); LUSC cis rs6460942 0.908 rs112049544 chr7:12242551 A/G cg06484146 chr7:12443880 VWDE -0.59 -5.87 -0.31 1.02e-8 Coronary artery disease; LUSC trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg03929089 chr4:120376271 NA 0.79 10.08 0.48 5.01e-21 Coronary artery disease; LUSC cis rs765787 0.530 rs3759893 chr15:45542950 G/T cg25801113 chr15:45476975 SHF 0.34 7.04 0.36 1.13e-11 Uric acid levels; LUSC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.98 13.75 0.6 2.2e-34 Smoking behavior; LUSC cis rs2439831 0.850 rs28476182 chr15:44139643 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.87 8.54 0.42 4.94e-16 Lung cancer in ever smokers; LUSC trans rs2392780 0.785 rs13256275 chr8:128356226 G/A cg10897648 chr18:56338258 MALT1 -0.38 -5.96 -0.31 6.46e-9 Breast cancer (early onset); LUSC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg00784671 chr22:46762841 CELSR1 -0.49 -6.67 -0.34 1.04e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs432925 0.529 rs2885415 chr16:395396 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 -0.38 -6.09 -0.32 3.03e-9 Morning vs. evening chronotype; LUSC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg16060761 chr17:80687452 NA 0.46 7.33 0.37 1.76e-12 Breast cancer; LUSC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg03433033 chr1:76189801 ACADM 0.83 15.3 0.64 2.09e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.79e-30 Prudent dietary pattern; LUSC cis rs57590327 0.555 rs13099615 chr3:81729101 T/A cg07356753 chr3:81810745 GBE1 -0.68 -10.51 -0.5 1.68e-22 Extraversion; LUSC trans rs6076960 0.684 rs3852949 chr20:6264758 T/A cg21095983 chr6:86352623 SYNCRIP 0.54 8.57 0.42 4.02e-16 Smooth-surface caries; LUSC cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.21 0.32 1.54e-9 Personality dimensions; LUSC cis rs3813567 0.702 rs7164665 chr15:78953919 T/C cg04896959 chr15:78267971 NA -0.42 -6.72 -0.34 8.09e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs11122272 0.735 rs2739516 chr1:231505527 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs10489202 0.632 rs202265 chr1:167990231 G/C cg24449463 chr1:168025552 DCAF6 -0.79 -13.37 -0.59 5.98e-33 Schizophrenia; LUSC cis rs35146811 0.660 rs6465760 chr7:99591418 A/G cg22906224 chr7:99728672 NA -0.46 -6.49 -0.33 3.17e-10 Coronary artery disease; LUSC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg16308533 chr17:40838983 CNTNAP1 0.51 8.97 0.44 2.21e-17 Colorectal or endometrial cancer; LUSC cis rs1670533 1.000 rs676561 chr4:1083112 C/T cg02018176 chr4:1364513 KIAA1530 0.45 6.34 0.33 7.29e-10 Recombination rate (females); LUSC cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg04978709 chr7:75101039 POM121C -0.39 -5.73 -0.3 2.3e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg05283184 chr6:79620031 NA -0.55 -11.29 -0.53 2.85e-25 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg07701084 chr6:150067640 NUP43 0.53 7.85 0.39 5.88e-14 Lung cancer; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg06877462 chr1:205807181 PM20D1 0.45 8.0 0.4 2.11e-14 Menarche (age at onset); LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg25703541 chr22:24373054 LOC391322 0.87 14.28 0.62 1.88e-36 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12368653 0.583 rs7952989 chr12:58095989 T/C cg12615879 chr12:58013172 SLC26A10 0.36 8.25 0.41 3.72e-15 Multiple sclerosis; LUSC cis rs1832871 0.672 rs62437361 chr6:158728759 C/T cg07165851 chr6:158734300 TULP4 0.45 6.63 0.34 1.36e-10 Height; LUSC cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg08754478 chr10:133766260 PPP2R2D -0.63 -8.13 -0.41 8.49e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg26677194 chr12:130822605 PIWIL1 0.59 8.77 0.43 9.52e-17 Menopause (age at onset); LUSC cis rs835154 0.845 rs835156 chr5:14875813 C/A cg14843632 chr5:14870594 ANKH 0.36 6.54 0.34 2.28e-10 Blood metabolite levels; LUSC cis rs2274273 0.661 rs8019978 chr14:55557284 A/G cg04306507 chr14:55594613 LGALS3 -0.51 -11.26 -0.52 3.75e-25 Protein biomarker; LUSC cis rs4631830 0.863 rs2249986 chr10:51521684 T/G cg10326726 chr10:51549505 MSMB -0.36 -6.18 -0.32 1.86e-9 Prostate-specific antigen levels; LUSC cis rs10832963 1.000 rs4757676 chr11:18640477 C/T cg20219074 chr11:18656078 SPTY2D1 0.76 11.3 0.53 2.83e-25 Breast cancer; LUSC cis rs11758351 0.866 rs77205516 chr6:26205356 T/A cg23601095 chr6:26197514 HIST1H3D 0.72 7.7 0.39 1.51e-13 Gout;Renal underexcretion gout; LUSC cis rs478304 0.934 rs474483 chr11:65520060 T/G cg05805236 chr11:65401703 PCNXL3 0.4 6.87 0.35 3.1e-11 Acne (severe); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16202187 chr19:17186497 HAUS8;MYO9B -0.41 -6.18 -0.32 1.84e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2427308 0.607 rs1741635 chr20:60938197 C/G cg22601191 chr20:60968625 CABLES2 -0.53 -7.55 -0.38 4.16e-13 Colorectal cancer; LUSC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.8 0.47 4.22e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs1459104 0.866 rs28873990 chr11:54812748 G/A cg03929089 chr4:120376271 NA 0.72 6.26 0.32 1.17e-9 Body mass index; LUSC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg16545954 chr1:2118288 C1orf86 0.38 7.41 0.38 1.06e-12 Height; LUSC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg01503450 chr10:980765 NA -0.38 -5.7 -0.3 2.68e-8 Eosinophil percentage of granulocytes; LUSC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg27494647 chr7:150038898 RARRES2 0.46 6.99 0.36 1.52e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs3820068 0.577 rs9728986 chr1:16040603 G/A cg24675056 chr1:15929824 NA 0.4 6.58 0.34 1.87e-10 Systolic blood pressure; LUSC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg26441486 chr22:50317300 CRELD2 -0.54 -8.2 -0.41 5.07e-15 Schizophrenia; LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg25767906 chr1:53392781 SCP2 0.49 8.74 0.43 1.13e-16 Monocyte count; LUSC cis rs9921338 0.961 rs8060767 chr16:11370598 C/G cg00044050 chr16:11439710 C16orf75 -0.51 -6.81 -0.35 4.64e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg00484396 chr16:3507460 NAT15 0.69 12.08 0.55 3.93e-28 Tuberculosis; LUSC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -9.98 -0.48 1.09e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs11690935 0.632 rs62184165 chr2:172558328 A/G cg13550731 chr2:172543902 DYNC1I2 0.6 9.54 0.46 3.05e-19 Schizophrenia; LUSC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.46 -0.53 7.24e-26 Schizophrenia; LUSC cis rs9399401 0.849 rs962554 chr6:142734204 T/C cg03128060 chr6:142623767 GPR126 0.34 6.1 0.32 2.95e-9 Chronic obstructive pulmonary disease; LUSC cis rs10208940 0.920 rs7423646 chr2:68758180 A/G cg12452813 chr2:68675892 NA 0.56 5.81 0.3 1.45e-8 Urate levels in lean individuals; LUSC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg00945038 chr17:61921165 SMARCD2 0.35 5.9 0.31 8.8e-9 Prudent dietary pattern; LUSC cis rs2274273 0.529 rs7149965 chr14:55508191 G/A cg04306507 chr14:55594613 LGALS3 0.44 8.95 0.44 2.53e-17 Protein biomarker; LUSC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg21782813 chr7:2030301 MAD1L1 0.38 6.19 0.32 1.78e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10843647 1.000 rs1968879 chr12:30322860 T/A cg12718339 chr12:29936407 TMTC1 -0.35 -5.77 -0.3 1.85e-8 Glucose homeostasis traits; LUSC trans rs11098499 0.909 rs11098530 chr4:120413154 C/T cg25214090 chr10:38739885 LOC399744 0.54 8.06 0.4 1.36e-14 Corneal astigmatism; LUSC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg02034447 chr16:89574710 SPG7 0.45 6.73 0.35 7.36e-11 Multiple myeloma (IgH translocation); LUSC cis rs3808502 0.516 rs6983727 chr8:11415812 A/G cg21775007 chr8:11205619 TDH 0.55 7.91 0.4 3.87e-14 Neuroticism; LUSC cis rs10887741 0.690 rs7908056 chr10:89444650 G/A cg24243914 chr10:89418206 PAPSS2 0.33 6.37 0.33 6.17e-10 Exercise (leisure time); LUSC cis rs1005224 0.819 rs10147492 chr14:76155309 T/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.67 -9.09 -0.45 8.91e-18 Large artery stroke; LUSC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg14668632 chr7:2872130 GNA12 -0.41 -6.02 -0.31 4.65e-9 Height; LUSC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg20203395 chr5:56204925 C5orf35 -0.58 -8.34 -0.42 1.93e-15 Coronary artery disease; LUSC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg17366294 chr4:99064904 C4orf37 0.59 10.39 0.49 4.12e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs3755132 0.929 rs41264163 chr2:15763788 C/T cg12888861 chr2:15731646 DDX1 0.51 7.2 0.37 3.99e-12 Wilms tumor; LUSC cis rs4280164 0.551 rs3212243 chr14:24810370 T/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.55 -6.86 -0.35 3.38e-11 Parent of origin effect on language impairment (paternal); LUSC cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg10978503 chr1:24200527 CNR2 -0.44 -9.28 -0.45 2.14e-18 Immature fraction of reticulocytes; LUSC cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC trans rs7474896 0.616 rs2474561 chr10:38373544 C/T cg17830980 chr10:43048298 ZNF37B -0.5 -6.26 -0.32 1.15e-9 Obesity (extreme); LUSC trans rs11088226 1.000 rs11701091 chr21:33920244 T/A cg09050820 chr6:167586206 TCP10L2 0.55 7.17 0.37 4.88e-12 Gastritis; LUSC trans rs7615952 0.688 rs12638240 chr3:125541238 G/A cg07211511 chr3:129823064 LOC729375 -1.0 -13.81 -0.6 1.2e-34 Blood pressure (smoking interaction); LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.7 -10.13 -0.48 3.24e-21 Systemic lupus erythematosus; LUSC cis rs28647808 0.881 rs28622217 chr9:136267323 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs4243830 0.522 rs10864614 chr1:6596008 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.85 -10.3 -0.49 8.86e-22 Body mass index; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg16393715 chr7:1948819 MAD1L1 0.36 6.22 0.32 1.48e-9 Bipolar disorder and schizophrenia; LUSC cis rs9788682 1.000 rs12441426 chr15:78812329 T/C cg06917634 chr15:78832804 PSMA4 -0.57 -7.1 -0.36 7.66e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs66887589 0.616 rs11732621 chr4:120212883 A/C cg09307838 chr4:120376055 NA 0.52 7.87 0.4 4.95e-14 Diastolic blood pressure; LUSC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg13683864 chr3:40499215 RPL14 -0.95 -16.3 -0.67 2.4e-44 Renal cell carcinoma; LUSC cis rs7607369 0.536 rs13033409 chr2:219666509 T/G cg02176678 chr2:219576539 TTLL4 -0.51 -8.94 -0.44 2.63e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs10782582 0.569 rs1770892 chr1:76389359 T/C cg03433033 chr1:76189801 ACADM -0.4 -5.89 -0.31 9.31e-9 Daytime sleep phenotypes; LUSC cis rs7827545 1.000 rs7827545 chr8:135566567 C/T cg17885191 chr8:135476712 NA 0.57 8.73 0.43 1.24e-16 Hypertension (SNP x SNP interaction); LUSC cis rs10911251 0.546 rs20560 chr1:183105534 T/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.58 0.5 9.49e-23 Colorectal cancer; LUSC cis rs9463078 0.608 rs608941 chr6:44888740 C/T cg25276700 chr6:44698697 NA -0.28 -5.78 -0.3 1.76e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.82 -15.25 -0.64 3.22e-40 Birth weight; LUSC cis rs10779751 0.734 rs1194820 chr1:11129259 A/C cg08854313 chr1:11322531 MTOR 0.81 12.26 0.56 8.54e-29 Body mass index; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23564928 chr14:32030597 NUBPL -0.4 -6.31 -0.33 8.89e-10 Electrocardiographic conduction measures; LUSC cis rs1692580 0.870 rs263533 chr1:2163568 C/T cg21194808 chr1:2205498 SKI 0.36 5.71 0.3 2.44e-8 Coronary artery disease; LUSC cis rs34421088 0.506 rs2572426 chr8:11147123 C/T cg21775007 chr8:11205619 TDH 0.51 7.46 0.38 7.58e-13 Neuroticism; LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg05347473 chr6:146136440 FBXO30 0.45 7.68 0.39 1.73e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg14582100 chr15:45693742 SPATA5L1 0.49 8.36 0.42 1.69e-15 Homoarginine levels; LUSC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg00944433 chr1:107599041 PRMT6 0.39 7.11 0.36 7.09e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs5769707 0.521 rs6009807 chr22:50058922 A/G cg05373962 chr22:49881684 NA -0.4 -8.46 -0.42 8.69e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs5758659 0.519 rs133307 chr22:42396568 C/A cg04733989 chr22:42467013 NAGA 0.39 6.54 0.34 2.33e-10 Cognitive function; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg18110333 chr6:292329 DUSP22 -0.53 -7.93 -0.4 3.38e-14 Menopause (age at onset); LUSC cis rs72960926 0.744 rs16884519 chr6:74967946 C/T cg03266952 chr6:74778945 NA 0.65 6.3 0.33 9.54e-10 Metabolite levels (MHPG); LUSC cis rs7589342 0.862 rs12613864 chr2:106515869 G/A cg16077055 chr2:106428750 NCK2 0.35 6.5 0.34 2.96e-10 Addiction; LUSC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg15145296 chr3:125709740 NA -0.57 -6.97 -0.36 1.66e-11 Blood pressure (smoking interaction); LUSC cis rs17685 0.753 rs1639609 chr7:75683581 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.5 -7.68 -0.39 1.74e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6028335 0.674 rs974561 chr20:37591184 G/C cg27552599 chr20:37590471 DHX35 0.45 5.67 0.3 3.15e-8 Alcohol and nicotine co-dependence; LUSC cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg03146154 chr1:46216737 IPP -0.5 -7.26 -0.37 2.69e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7819412 0.521 rs4451268 chr8:11034859 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.59 -0.34 1.75e-10 Triglycerides; LUSC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg20933634 chr6:27740509 NA 0.43 5.93 0.31 7.46e-9 Parkinson's disease; LUSC trans rs57046232 0.552 rs6133307 chr20:6333298 C/T cg17788362 chr6:86352627 SYNCRIP 0.42 5.96 0.31 6.34e-9 Colorectal cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26824705 chr1:20834772 MUL1 0.43 6.46 0.33 3.7e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13256369 0.755 rs11776987 chr8:8559401 C/G cg06671706 chr8:8559999 CLDN23 0.51 6.55 0.34 2.12e-10 Obesity-related traits; LUSC cis rs3857536 0.740 rs7756519 chr6:66892275 A/G cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.27 0.52 3.55e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs7312933 0.533 rs11181499 chr12:42818761 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.91 0.35 2.51e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4073582 0.595 rs801734 chr11:65931216 T/C cg14036092 chr11:66035641 RAB1B 0.42 5.93 0.31 7.38e-9 Gout; LUSC cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg18132916 chr6:79620363 NA -0.39 -5.91 -0.31 8.33e-9 Intelligence (multi-trait analysis); LUSC cis rs6088590 0.748 rs6142206 chr20:33212055 G/A cg08999081 chr20:33150536 PIGU 0.46 8.35 0.42 1.84e-15 Coronary artery disease; LUSC cis rs3007729 0.509 rs6665151 chr1:18800247 A/G cg04846421 chr1:18800208 NA -0.41 -7.14 -0.36 5.69e-12 Diabetic retinopathy; LUSC cis rs10752881 1.000 rs6424879 chr1:182986592 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.27e-22 Colorectal cancer; LUSC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg27532560 chr4:187881888 NA -0.41 -6.72 -0.35 7.9e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.92e-21 Monocyte count; LUSC cis rs2985684 0.802 rs10150823 chr14:50051751 C/T cg04989706 chr14:50066350 PPIL5 -0.46 -6.21 -0.32 1.57e-9 Carotid intima media thickness; LUSC cis rs9303401 0.659 rs12946397 chr17:56769979 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs4594175 0.926 rs12101170 chr14:51611902 T/C cg23942311 chr14:51606299 NA 0.3 5.79 0.3 1.6e-8 Cancer; LUSC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg02423579 chr7:2872169 GNA12 -0.41 -6.13 -0.32 2.43e-9 Height; LUSC cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg04455712 chr21:45112962 RRP1B 0.48 9.18 0.45 4.67e-18 Mean corpuscular volume; LUSC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg15445000 chr17:37608096 MED1 -0.39 -6.63 -0.34 1.35e-10 Glomerular filtration rate (creatinine); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17504096 chr1:205649242 SLC45A3 -0.5 -6.25 -0.32 1.24e-9 Bipolar disorder and schizophrenia; LUSC trans rs11694459 0.661 rs731399 chr2:46457657 A/C cg01370541 chr4:41882812 NA 0.68 6.34 0.33 7.33e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs12579753 0.871 rs35801863 chr12:82238818 A/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg16586182 chr3:47516702 SCAP -0.51 -7.84 -0.39 6.3e-14 Colorectal cancer; LUSC cis rs7246967 0.673 rs12974988 chr19:22925965 G/T cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs17253792 0.822 rs75288952 chr14:56034010 C/T cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.64 13.67 0.6 4.2e-34 Monocyte percentage of white cells; LUSC cis rs10871290 1.000 rs11149710 chr16:74472546 G/T cg01733217 chr16:74700730 RFWD3 -0.54 -7.84 -0.39 6e-14 Breast cancer; LUSC cis rs6840360 0.533 rs4696297 chr4:152725838 T/G cg22705602 chr4:152727874 NA 0.38 7.85 0.39 5.54e-14 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.818 rs406350 chr1:153007492 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC trans rs561341 1.000 rs530715 chr17:30320544 T/G cg27661571 chr11:113659931 NA -0.62 -7.41 -0.38 1.05e-12 Hip circumference adjusted for BMI; LUSC cis rs3806843 0.576 rs246064 chr5:140324309 C/G cg19875535 chr5:140030758 IK 0.37 5.66 0.3 3.3e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg05368731 chr17:41323189 NBR1 0.9 13.42 0.59 3.99e-33 Menopause (age at onset); LUSC cis rs7617480 0.648 rs9864243 chr3:48982732 G/A cg07636037 chr3:49044803 WDR6 0.9 12.03 0.55 6.16e-28 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.15 -0.32 2.25e-9 Bipolar disorder; LUSC trans rs9944715 1.000 rs3744858 chr18:43845269 C/T cg01718231 chr17:29326311 RNF135 -0.5 -6.95 -0.36 1.97e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.37 5.65 0.3 3.45e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs11605924 0.901 rs7112505 chr11:45840939 A/T ch.11.939596F chr11:45881766 CRY2 -0.5 -7.44 -0.38 8.7e-13 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg18099408 chr3:52552593 STAB1 -0.41 -7.06 -0.36 9.62e-12 Bipolar disorder; LUSC cis rs4363385 0.693 rs7556517 chr1:152925755 G/T cg00922841 chr1:152955080 SPRR1A 0.42 7.03 0.36 1.18e-11 Inflammatory skin disease; LUSC cis rs12545109 0.800 rs970838 chr8:57414806 A/G cg09654669 chr8:57350985 NA -0.57 -7.83 -0.39 6.46e-14 Obesity-related traits; LUSC cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.67 -7.91 -0.4 3.69e-14 Lung function (FEV1/FVC); LUSC cis rs1865760 0.713 rs6928951 chr6:25995554 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 6.84 0.35 3.68e-11 Height; LUSC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg16339924 chr4:17578868 LAP3 0.62 9.56 0.46 2.68e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg12288994 chr5:1860383 NA 0.31 6.91 0.35 2.43e-11 Cardiovascular disease risk factors; LUSC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg20608306 chr11:116969690 SIK3 0.34 6.35 0.33 6.84e-10 Blood protein levels; LUSC cis rs12586317 0.531 rs60049741 chr14:35719842 G/A cg07166546 chr14:35805898 NA -0.28 -6.51 -0.34 2.7e-10 Psoriasis; LUSC cis rs752010 1.000 rs6664724 chr1:42093821 G/A cg06885757 chr1:42089581 HIVEP3 0.46 9.38 0.46 1.07e-18 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg24531977 chr5:56204891 C5orf35 -0.71 -10.56 -0.5 1.11e-22 Coronary artery disease; LUSC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg18230493 chr5:56204884 C5orf35 -0.86 -13.06 -0.58 8.73e-32 Initial pursuit acceleration; LUSC cis rs9309473 0.528 rs7573275 chr2:73552542 G/A cg20560298 chr2:73613845 ALMS1 -0.53 -7.66 -0.39 2.01e-13 Metabolite levels; LUSC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg09021430 chr5:549028 NA -0.54 -7.41 -0.38 1.05e-12 Lung disease severity in cystic fibrosis; LUSC cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg10596483 chr8:143751796 JRK -0.52 -7.39 -0.37 1.19e-12 Schizophrenia; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg27094323 chr7:1216898 NA 0.4 6.99 0.36 1.51e-11 Longevity;Endometriosis; LUSC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 -0.46 -7.51 -0.38 5.47e-13 Vitiligo; LUSC cis rs4808199 0.948 rs2301668 chr19:19452249 G/A cg03709012 chr19:19516395 GATAD2A 0.99 12.02 0.55 6.84e-28 Nonalcoholic fatty liver disease; LUSC cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg04455712 chr21:45112962 RRP1B 0.42 7.82 0.39 6.79e-14 Mean corpuscular volume; LUSC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg18305652 chr10:134549665 INPP5A -0.42 -6.42 -0.33 4.69e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs3931020 0.688 rs452242 chr1:75225625 G/T cg00121533 chr1:75199117 CRYZ;TYW3 -0.47 -5.86 -0.31 1.11e-8 Resistin levels; LUSC cis rs7615316 1.000 rs1357529 chr3:142351097 T/G cg16271453 chr3:142027066 XRN1 -0.34 -5.82 -0.3 1.36e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs61931739 0.569 rs1872746 chr12:33985843 T/C cg26384229 chr12:38710491 ALG10B 0.58 9.3 0.45 1.91e-18 Morning vs. evening chronotype; LUSC cis rs67311347 0.577 rs1880763 chr3:40283255 C/T cg13683864 chr3:40499215 RPL14 0.79 13.04 0.58 1.07e-31 Renal cell carcinoma; LUSC cis rs6964587 0.843 rs56075286 chr7:91731518 G/A cg17063962 chr7:91808500 NA 0.58 9.24 0.45 2.88e-18 Breast cancer; LUSC trans rs1941687 0.527 rs2000945 chr18:31365336 A/G cg13755796 chr4:20253514 NA -0.42 -6.51 -0.34 2.74e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg13390004 chr1:15929781 NA 0.4 6.68 0.34 1e-10 Systolic blood pressure; LUSC cis rs1580019 0.844 rs1376290 chr7:32486922 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.83 12.22 0.56 1.26e-28 Cognitive ability; LUSC cis rs4969178 0.930 rs4580257 chr17:76403028 T/G cg05887092 chr17:76393375 PGS1 0.51 8.66 0.43 2.12e-16 HDL cholesterol levels; LUSC trans rs62238980 0.614 rs4821027 chr22:32442074 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs12122100 1.000 rs12122100 chr1:146508934 C/T cg03526459 chr1:146549940 NA -0.41 -6.74 -0.35 7.12e-11 HIV-1 control; LUSC cis rs2580764 0.565 rs2919129 chr2:55216545 G/T cg09592903 chr2:55203963 RTN4 0.49 10.18 0.49 2.16e-21 Mean platelet volume; LUSC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg09491104 chr22:46646882 C22orf40 -0.64 -7.22 -0.37 3.64e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs735860 0.674 rs209485 chr6:53174448 C/T cg10236188 chr6:53219634 NA -0.39 -6.23 -0.32 1.43e-9 Glaucoma; LUSC cis rs2072499 0.898 rs2736609 chr1:156202640 C/T cg25208724 chr1:156163844 SLC25A44 1.02 20.47 0.75 6.66e-61 Testicular germ cell tumor; LUSC cis rs1775715 0.870 rs10827003 chr10:32266216 A/G cg18675610 chr10:32216311 ARHGAP12 0.27 5.74 0.3 2.07e-8 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs7824557 0.602 rs11781375 chr8:11204532 A/G cg15556689 chr8:8085844 FLJ10661 0.49 7.18 0.37 4.43e-12 Retinal vascular caliber; LUSC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.05 0.48 6.03e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs67981189 0.679 rs221901 chr14:71602226 C/T cg15816911 chr14:71606274 NA -0.35 -6.33 -0.33 7.7e-10 Schizophrenia; LUSC cis rs8099014 0.861 rs17669 chr18:56118493 C/T cg12907477 chr18:56117327 MIR122 0.45 7.01 0.36 1.29e-11 Platelet count; LUSC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg22442454 chr1:209979470 IRF6 0.44 5.99 0.31 5.49e-9 Cleft lip with or without cleft palate; LUSC cis rs9660992 0.639 rs1151786 chr1:205227760 G/C cg21643547 chr1:205240462 TMCC2 -0.53 -10.02 -0.48 7.99e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7523273 0.606 rs859706 chr1:207962270 G/A cg22525895 chr1:207977042 MIR29B2 -0.41 -6.66 -0.34 1.15e-10 Schizophrenia; LUSC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg06671706 chr8:8559999 CLDN23 0.48 6.52 0.34 2.59e-10 Obesity-related traits; LUSC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg00933542 chr6:150070202 PCMT1 0.3 6.0 0.31 5.27e-9 Lung cancer; LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg01206211 chr2:36825736 FEZ2 0.52 10.89 0.51 7.67e-24 Height; LUSC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg23985595 chr17:80112537 CCDC57 0.3 5.74 0.3 2.14e-8 Life satisfaction; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg22963979 chr7:1858916 MAD1L1 -0.58 -9.17 -0.45 4.93e-18 Autism spectrum disorder or schizophrenia; LUSC trans rs561341 0.941 rs2470236 chr17:30304940 G/C cg27661571 chr11:113659931 NA -0.6 -7.25 -0.37 2.83e-12 Hip circumference adjusted for BMI; LUSC cis rs6736093 0.932 rs7595212 chr2:112662767 A/G cg12686935 chr2:112915763 FBLN7 -0.39 -5.99 -0.31 5.37e-9 Coronary artery disease; LUSC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg04287289 chr16:89883240 FANCA -0.48 -7.15 -0.36 5.47e-12 Vitiligo; LUSC cis rs4867766 0.871 rs2242419 chr5:173959332 C/T cg20434911 chr5:173954559 NA 0.51 7.09 0.36 8.18e-12 Stroke; LUSC cis rs9300255 0.770 rs12299125 chr12:123862447 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.4 6.21 0.32 1.56e-9 Neutrophil percentage of white cells; LUSC cis rs4332037 1.000 rs4332037 chr7:1950809 C/T cg23422044 chr7:1970798 MAD1L1 -0.64 -7.24 -0.37 3.07e-12 Bipolar disorder; LUSC cis rs13089785 1.000 rs34159794 chr3:123645893 A/G cg02558132 chr3:123411198 MYLK 0.34 5.85 0.3 1.19e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg22920501 chr2:26401640 FAM59B -0.73 -10.59 -0.5 8.37e-23 Gut microbiome composition (summer); LUSC cis rs1997103 0.863 rs4480062 chr7:55401299 T/C cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg16362232 chr11:430036 ANO9 0.57 7.49 0.38 6.26e-13 Body mass index; LUSC cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC cis rs7523050 0.643 rs12741194 chr1:109400390 T/C cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg09455208 chr3:40491958 NA 0.57 10.34 0.49 6.5600000000000005e-22 Renal cell carcinoma; LUSC cis rs11971779 0.616 rs2883772 chr7:139072756 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg04155289 chr7:94953770 PON1 -0.36 -5.96 -0.31 6.54e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs17401966 0.838 rs1556917 chr1:10400990 G/T cg19773385 chr1:10388646 KIF1B -0.5 -8.63 -0.43 2.62e-16 Hepatocellular carcinoma; LUSC cis rs34779708 0.733 rs7914560 chr10:35548099 G/A cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg06112835 chr11:68658793 MRPL21 0.51 7.88 0.4 4.58e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22987389 chr8:22428557 SORBS3 0.5 6.76 0.35 5.99e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs208520 0.874 rs208515 chr6:66945749 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.93 -0.61 4.39e-35 Exhaled nitric oxide output; LUSC cis rs17407555 0.738 rs55731306 chr4:10067885 G/T cg11266682 chr4:10021025 SLC2A9 -0.47 -6.27 -0.32 1.15e-9 Schizophrenia (age at onset); LUSC trans rs8072100 0.840 rs11079774 chr17:45479706 C/G cg03886242 chr7:26192032 NFE2L3 -0.39 -6.38 -0.33 5.9e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg06494592 chr3:125709126 NA -0.5 -5.75 -0.3 2.04e-8 Blood pressure (smoking interaction); LUSC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg09365446 chr1:150670422 GOLPH3L 0.48 7.21 0.37 3.71e-12 Melanoma; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg11905131 chr22:24372483 LOC391322 -0.61 -10.45 -0.5 2.71e-22 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10751667 1.000 rs7396798 chr11:970510 G/T ch.11.42038R chr11:967971 AP2A2 0.54 8.19 0.41 5.56e-15 Alzheimer's disease (late onset); LUSC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.68 -0.43 1.83e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs2274273 0.624 rs10129505 chr14:55776375 C/T cg04306507 chr14:55594613 LGALS3 0.49 10.11 0.48 3.86e-21 Protein biomarker; LUSC cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC trans rs60843830 1.000 rs55753056 chr2:243929 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 10.54 0.5 1.29e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs2243480 0.901 rs34807232 chr7:65965133 G/A cg10756647 chr7:56101905 PSPH 0.87 8.84 0.44 5.54e-17 Diabetic kidney disease; LUSC trans rs17683430 0.718 rs117277832 chr22:32369667 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.45 -0.38 8.3e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7178572 0.568 rs12914345 chr15:77670401 A/C cg22256960 chr15:77711686 NA -0.49 -7.82 -0.39 6.91e-14 Type 2 diabetes; LUSC cis rs34779708 0.966 rs12774834 chr10:35400070 A/T cg03585969 chr10:35415529 CREM 0.62 8.97 0.44 2.2e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg00033643 chr7:134001901 SLC35B4 0.45 6.83 0.35 3.97e-11 Mean platelet volume; LUSC cis rs6977660 0.714 rs6945297 chr7:19814029 A/C cg05791153 chr7:19748676 TWISTNB 0.7 7.47 0.38 7.27e-13 Thyroid stimulating hormone; LUSC cis rs7202877 0.519 rs4887811 chr16:75307251 C/T cg04384234 chr16:75411784 CFDP1 -0.65 -9.36 -0.46 1.18e-18 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7945718 0.905 rs10831908 chr11:12812419 G/A cg25843174 chr11:12811716 TEAD1 0.33 7.25 0.37 2.99e-12 Educational attainment (years of education); LUSC cis rs13315871 0.790 rs13071148 chr3:58310838 A/C cg12435725 chr3:58293450 RPP14 -0.76 -7.39 -0.37 1.23e-12 Cholesterol, total; LUSC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs1008375 0.646 rs13103430 chr4:17567355 A/C cg04450456 chr4:17643702 FAM184B -0.41 -6.02 -0.31 4.65e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5769707 0.605 rs6009791 chr22:50025265 T/C cg05373962 chr22:49881684 NA -0.41 -8.72 -0.43 1.37e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2742234 0.579 rs2503881 chr10:43686026 T/C cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs4363385 0.818 rs529077 chr1:153012149 T/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg13298116 chr11:62369859 EML3;MTA2 0.59 9.65 0.47 1.33e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7809950 1.000 rs2178497 chr7:107278901 T/C cg23024343 chr7:107201750 COG5 0.54 8.23 0.41 4.16e-15 Coronary artery disease; LUSC trans rs7681440 0.874 rs1372525 chr4:90776165 G/A cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.96 -0.31 6.49e-9 Dementia with Lewy bodies; LUSC cis rs899997 1.000 rs11629824 chr15:79005524 T/G cg24631222 chr15:78858424 CHRNA5 -0.42 -5.78 -0.3 1.74e-8 Coronary artery disease or large artery stroke; LUSC cis rs35883536 0.588 rs114540631 chr1:101101249 A/G cg06223162 chr1:101003688 GPR88 0.34 6.21 0.32 1.55e-9 Monocyte count; LUSC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg03264133 chr6:25882463 NA -0.43 -6.61 -0.34 1.52e-10 Intelligence (multi-trait analysis); LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg16362232 chr11:430036 ANO9 0.61 7.97 0.4 2.51e-14 Body mass index; LUSC cis rs7809950 1.000 rs12668402 chr7:107173020 G/A cg23024343 chr7:107201750 COG5 -0.56 -8.81 -0.43 7.12e-17 Coronary artery disease; LUSC cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg13535736 chr9:111863775 C9orf5 -0.38 -5.95 -0.31 6.63e-9 Menarche (age at onset); LUSC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs13040088 1.000 rs910831 chr20:61558775 T/C cg23096297 chr20:61557774 DIDO1 0.8 10.65 0.5 5.38e-23 Menopause (age at onset); LUSC cis rs7584330 0.628 rs7591065 chr2:238390739 G/T cg14458575 chr2:238380390 NA 0.47 6.0 0.31 5.11e-9 Prostate cancer; LUSC cis rs2762353 0.603 rs9393670 chr6:25789061 A/G cg03264133 chr6:25882463 NA 0.37 6.46 0.33 3.61e-10 Blood metabolite levels; LUSC cis rs7177699 0.525 rs7402376 chr15:79113570 A/G cg00540400 chr15:79124168 NA -0.48 -8.43 -0.42 1.04e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.43 6.02 0.31 4.67e-9 Height; LUSC cis rs354225 0.544 rs7556752 chr2:54810044 G/C cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg26597838 chr10:835615 NA 0.81 11.35 0.53 1.73e-25 Eosinophil percentage of granulocytes; LUSC cis rs7903847 0.667 rs11189181 chr10:99144154 A/G cg20016023 chr10:99160130 RRP12 -0.35 -8.3 -0.41 2.63e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs57590327 0.555 rs13088603 chr3:81791167 A/G cg07356753 chr3:81810745 GBE1 -0.67 -10.65 -0.5 5.4e-23 Extraversion; LUSC trans rs67133203 0.904 rs7975147 chr12:51425549 A/G cg17484237 chr5:156536107 HAVCR2 0.44 5.97 0.31 6.2e-9 Urinary tract infection frequency; LUSC cis rs4474465 0.920 rs10899527 chr11:78207394 A/G cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs4845570 0.764 rs12141652 chr1:151716711 A/T cg07092448 chr1:151763213 TDRKH -1.05 -10.9 -0.51 6.96e-24 Coronary artery disease; LUSC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg04944784 chr2:26401820 FAM59B 0.74 10.32 0.49 7.14e-22 Gut microbiome composition (summer); LUSC cis rs617219 0.819 rs2591387 chr5:78558425 C/T cg24856658 chr5:78533917 JMY -0.3 -5.82 -0.3 1.37e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg05738196 chr6:26577821 NA -0.59 -7.08 -0.36 8.49e-12 Intelligence (multi-trait analysis); LUSC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg22823121 chr1:150693482 HORMAD1 0.6 9.34 0.46 1.35e-18 Tonsillectomy; LUSC cis rs7264396 0.635 rs6060719 chr20:34546013 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.83 -0.44 6.04e-17 Total cholesterol levels; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg07703079 chr11:430292 ANO9 0.72 7.38 0.37 1.23e-12 Body mass index; LUSC cis rs1483890 0.723 rs6783070 chr3:69411596 A/C cg22125112 chr3:69402811 FRMD4B -0.39 -5.9 -0.31 8.82e-9 Resting heart rate; LUSC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.37 -0.33 6.29e-10 Lung cancer; LUSC cis rs4947962 0.564 rs11764130 chr7:55078791 A/G cg23757825 chr7:55092271 EGFR 0.69 8.77 0.43 9.39e-17 Subjective response to lithium treatment; LUSC cis rs9467773 1.000 rs10214634 chr6:26564582 T/A cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.31e-21 Intelligence (multi-trait analysis); LUSC cis rs12493885 0.654 rs61793488 chr3:153730551 T/C cg17054900 chr3:154042577 DHX36 -0.7 -7.28 -0.37 2.4e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs6502050 0.835 rs62078305 chr17:80085326 G/A cg07393940 chr7:158741817 NA -0.37 -6.7 -0.34 8.85e-11 Life satisfaction; LUSC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg06238570 chr21:40685208 BRWD1 -0.63 -11.0 -0.52 3.14e-24 Cognitive function; LUSC cis rs2439831 0.850 rs3816792 chr15:44116986 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.7 -6.44 -0.33 4.06e-10 Lung cancer in ever smokers; LUSC cis rs6599077 1.000 rs11920120 chr3:40094795 T/C cg13683864 chr3:40499215 RPL14 -0.6 -7.66 -0.39 2.06e-13 Sleep-related phenotypes; LUSC trans rs9929218 0.520 rs1078621 chr16:68778996 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.96 18.97 0.72 5.76e-55 Colorectal cancer; LUSC cis rs7267979 1.000 rs6076345 chr20:25381895 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs599083 0.829 rs314751 chr11:68179560 C/T cg20283391 chr11:68216788 NA 0.5 6.78 0.35 5.4e-11 Bone mineral density (spine); LUSC cis rs3772130 1.000 rs13083794 chr3:121464928 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.64 9.28 0.45 2.14e-18 Cognitive performance; LUSC cis rs11971779 0.680 rs7805767 chr7:139111415 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg16339924 chr4:17578868 LAP3 0.49 7.46 0.38 7.73e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg01516881 chr6:292596 DUSP22 -0.7 -11.29 -0.53 3.07e-25 Menopause (age at onset); LUSC cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg26597838 chr10:835615 NA 0.79 9.3 0.45 1.88e-18 Eosinophil percentage of granulocytes; LUSC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg05585544 chr11:47624801 NA -0.36 -6.6 -0.34 1.64e-10 Subjective well-being; LUSC cis rs62458065 0.513 rs787220 chr7:32581139 C/G cg20159608 chr7:32802032 NA -0.7 -9.12 -0.45 7.4e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs10782582 0.532 rs12132503 chr1:76137762 C/G cg10523679 chr1:76189770 ACADM -0.5 -7.31 -0.37 2.02e-12 Daytime sleep phenotypes; LUSC cis rs921968 0.648 rs538483 chr2:219458656 T/C cg02176678 chr2:219576539 TTLL4 0.64 11.77 0.54 5.36e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs9807989 0.839 rs6543123 chr2:102977196 C/T cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.8 -10.39 -0.49 4.1e-22 Gut microbiome composition (summer); LUSC cis rs974417 0.508 rs17743380 chr6:97312271 C/T cg10979063 chr6:97285822 GPR63 0.45 7.3 0.37 2.06e-12 Body mass index; LUSC cis rs7178572 0.633 rs12900004 chr15:77844904 A/G cg22256960 chr15:77711686 NA -0.5 -7.68 -0.39 1.79e-13 Type 2 diabetes; LUSC cis rs9303401 0.659 rs62081316 chr17:56781499 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.28 0.59 1.28e-32 Cognitive test performance; LUSC cis rs1568889 0.838 rs1525717 chr11:28081205 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.89 0.58 3.95e-31 Bipolar disorder; LUSC cis rs4704187 0.687 rs9293643 chr5:74365053 C/T cg03227963 chr5:74354835 NA -0.3 -6.5 -0.34 2.95e-10 Response to amphetamines; LUSC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.76 0.47 5.93e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9430161 0.598 rs34350247 chr1:11034460 A/G cg27631724 chr1:11040367 C1orf127 0.54 9.56 0.46 2.75e-19 Ewing sarcoma; LUSC cis rs2481665 0.806 rs55725347 chr1:62538252 G/A cg18591186 chr1:62594603 INADL -0.43 -6.42 -0.33 4.73e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6693567 0.565 rs12736375 chr1:150411912 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.11 0.36 7.28e-12 Migraine; LUSC cis rs7200543 1.000 rs3803575 chr16:15138447 T/C cg03427771 chr16:15082598 PDXDC1 -0.41 -5.82 -0.3 1.42e-8 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg16786304 chr2:206950888 INO80D -0.52 -6.85 -0.35 3.57e-11 Hepatitis; LUSC cis rs2629540 0.765 rs11245387 chr10:126537825 C/T cg08799069 chr10:126477246 METTL10 -0.52 -7.78 -0.39 9.23e-14 Cocaine dependence; LUSC cis rs10504229 0.636 rs115738451 chr8:58055133 A/T cg08219700 chr8:58056026 NA 0.65 7.53 0.38 4.69e-13 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.545 rs7199878 chr16:68186301 A/G cg27539214 chr16:67997921 SLC12A4 -0.58 -7.12 -0.36 6.5e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg06064525 chr11:970664 AP2A2 -0.47 -10.5 -0.5 1.81e-22 Alzheimer's disease (late onset); LUSC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg23625390 chr15:77176239 SCAPER -0.46 -7.02 -0.36 1.22e-11 Blood metabolite levels; LUSC cis rs9399135 0.935 rs11759999 chr6:135370495 G/T cg22676075 chr6:135203613 NA 0.46 7.13 0.36 6.1e-12 Red blood cell count; LUSC cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.53 0.57 8.34e-30 Motion sickness; LUSC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg23625390 chr15:77176239 SCAPER 0.59 9.22 0.45 3.51e-18 Blood metabolite levels; LUSC cis rs4903604 0.581 rs12879719 chr14:78035253 C/A cg18872420 chr14:78023429 SPTLC2 0.38 5.87 0.31 1.05e-8 Gut microbiome composition (winter); LUSC cis rs9400467 0.528 rs7752361 chr6:111780705 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.46 -0.33 3.79e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs208520 0.690 rs12208310 chr6:66730108 G/C cg07460842 chr6:66804631 NA 1.1 17.27 0.69 3.24e-48 Exhaled nitric oxide output; LUSC cis rs11690935 1.000 rs2138348 chr2:172558172 A/C cg13550731 chr2:172543902 DYNC1I2 0.9 14.64 0.63 7.94e-38 Schizophrenia; LUSC cis rs425277 0.539 rs3128338 chr1:2046786 G/A cg04315214 chr1:2043799 PRKCZ 0.48 10.08 0.48 4.95e-21 Height; LUSC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9486719 0.843 rs1009597 chr6:96843540 A/T cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg10172584 chr19:19639581 YJEFN3 0.49 5.8 0.3 1.5e-8 Bipolar disorder; LUSC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg14784868 chr12:69753453 YEATS4 0.64 9.5 0.46 4.18e-19 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01330670 chr2:101767621 TBC1D8 -0.44 -6.49 -0.33 3.01e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg13256891 chr4:100009986 ADH5 0.52 7.03 0.36 1.2e-11 Smoking initiation; LUSC cis rs710216 0.957 rs710215 chr1:43429105 T/C cg22176566 chr1:43424700 SLC2A1 0.48 5.98 0.31 5.71e-9 Red cell distribution width; LUSC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg21862992 chr11:68658383 NA 0.49 7.91 0.4 3.92e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2559856 0.904 rs2695283 chr12:102089391 G/C cg12924262 chr12:102091054 CHPT1 0.43 6.07 0.32 3.47e-9 Blood protein levels; LUSC cis rs16910800 0.953 rs7126961 chr11:23204237 C/T cg20040320 chr11:23191996 NA -0.44 -6.46 -0.33 3.8e-10 Cancer; LUSC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg05025164 chr4:1340916 KIAA1530 0.63 9.75 0.47 6.5e-20 Longevity; LUSC cis rs1348850 0.958 rs4243390 chr2:178468008 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 6.33 0.33 7.99e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6121246 0.529 rs6060171 chr20:30183269 C/T cg18721089 chr20:30220636 NA -0.39 -6.15 -0.32 2.2e-9 Mean corpuscular hemoglobin; LUSC cis rs72781680 0.898 rs12614616 chr2:23996501 T/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs12541635 0.966 rs4734128 chr8:107026913 G/A cg10147462 chr8:107024639 NA 0.55 10.01 0.48 8.31e-21 Age of smoking initiation; LUSC cis rs721399 0.553 rs13262341 chr8:18243097 A/G cg18736775 chr8:18248649 NAT2 -0.57 -6.75 -0.35 6.68e-11 Blood metabolite levels; LUSC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg13683864 chr3:40499215 RPL14 -1.13 -21.03 -0.75 3.87e-63 Renal cell carcinoma; LUSC cis rs730566 1.000 rs730566 chr3:48487048 G/T cg21141812 chr3:48556323 PFKFB4 -0.32 -6.63 -0.34 1.33e-10 Prion diseases; LUSC cis rs35146811 0.735 rs1636978 chr7:99813912 G/A cg22906224 chr7:99728672 NA -0.5 -6.96 -0.36 1.78e-11 Coronary artery disease; LUSC cis rs1801251 1.000 rs1867778 chr2:233679644 C/T cg25237894 chr2:233734115 C2orf82 -0.36 -6.68 -0.34 1.01e-10 Coronary artery disease; LUSC cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg20135002 chr11:47629003 NA -0.49 -7.56 -0.38 4.02e-13 Subjective well-being; LUSC cis rs3803170 0.513 rs10849944 chr12:111825389 C/T cg10833066 chr12:111807467 FAM109A -0.4 -7.51 -0.38 5.54e-13 Mean corpuscular hemoglobin; LUSC cis rs1843834 0.929 rs4674934 chr2:225516468 A/T cg22455342 chr2:225449267 CUL3 -0.43 -6.2 -0.32 1.71e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg25767906 chr1:53392781 SCP2 -0.5 -9.11 -0.45 7.51e-18 Monocyte count; LUSC cis rs9303401 0.659 rs56162835 chr17:56687315 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC cis rs11098499 0.863 rs7699064 chr4:120428309 A/G cg24375607 chr4:120327624 NA -0.73 -10.83 -0.51 1.25e-23 Corneal astigmatism; LUSC cis rs17739794 0.517 rs4439155 chr8:781047 C/T cg01971667 chr8:817044 NA -0.4 -6.53 -0.34 2.48e-10 Clozapine-induced cytotoxicity; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg09177884 chr7:1199841 ZFAND2A -0.45 -6.36 -0.33 6.74e-10 Longevity;Endometriosis; LUSC cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg16586182 chr3:47516702 SCAP 0.52 7.4 0.38 1.13e-12 Birth weight; LUSC trans rs561341 1.000 rs2344312 chr17:30243583 G/T cg27661571 chr11:113659931 NA -0.54 -6.49 -0.33 3.02e-10 Hip circumference adjusted for BMI; LUSC cis rs1692580 0.682 rs12045693 chr1:2205581 A/C cg21194808 chr1:2205498 SKI -0.46 -7.8 -0.39 7.93e-14 Coronary artery disease; LUSC trans rs7829975 0.623 rs7010753 chr8:8373956 A/G cg21775007 chr8:11205619 TDH 0.44 6.32 0.33 8.36e-10 Mood instability; LUSC cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg01689657 chr7:91764605 CYP51A1 0.33 5.98 0.31 5.72e-9 Breast cancer; LUSC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg12463550 chr7:65579703 CRCP 0.51 7.38 0.37 1.26e-12 Aortic root size; LUSC cis rs4690686 0.500 rs11723131 chr4:177268602 G/A cg17059388 chr4:177262070 NA 0.46 8.6 0.43 3.22e-16 Essential tremor; LUSC cis rs8038465 1.000 rs8041181 chr15:73982336 C/T cg15420318 chr15:73925796 NPTN 0.39 6.15 0.32 2.17e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11122272 0.735 rs2808603 chr1:231537738 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.92 0.48 1.75e-20 Hemoglobin concentration; LUSC cis rs7760535 0.794 rs3851225 chr6:111825132 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.9 -0.35 2.59e-11 Metabolic traits; LUSC trans rs6951245 1.000 rs1881123 chr7:1084706 C/T cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg11812906 chr14:75593930 NEK9 0.64 10.69 0.51 3.74e-23 Height; LUSC cis rs11264213 0.901 rs581459 chr1:36375110 C/T cg27506609 chr1:36549197 TEKT2 0.49 6.87 0.35 3.06e-11 Schizophrenia; LUSC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.73e-14 Systolic blood pressure; LUSC cis rs2279817 0.735 rs34571066 chr1:18002777 A/C cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.2 -0.32 1.71e-9 Neuroticism; LUSC cis rs12249377 0.519 rs11599902 chr10:92598823 A/G cg14313238 chr10:92632228 RPP30 0.43 6.15 0.32 2.25e-9 White matter microstructure (global fractional anisotropy); LUSC cis rs9309473 1.000 rs13398956 chr2:73720258 C/A cg20560298 chr2:73613845 ALMS1 -0.45 -6.38 -0.33 5.81e-10 Metabolite levels; LUSC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.27e-11 Lung cancer; LUSC cis rs75804782 0.521 rs56087929 chr2:239455564 G/A cg18131467 chr2:239335373 ASB1 -0.63 -5.87 -0.31 1.03e-8 Morning vs. evening chronotype;Chronotype; LUSC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg25036284 chr2:26402008 FAM59B -0.7 -9.87 -0.48 2.52e-20 Gut microbiome composition (summer); LUSC cis rs3736594 0.879 rs4666011 chr2:27980912 G/C cg27432699 chr2:27873401 GPN1 0.64 8.82 0.43 6.5e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs244731 0.959 rs918459 chr5:176669030 C/T cg06060754 chr5:176797920 RGS14 -0.6 -8.78 -0.43 8.75e-17 Urate levels in lean individuals; LUSC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg11764359 chr7:65958608 NA -0.7 -10.7 -0.51 3.47e-23 Aortic root size; LUSC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg12365402 chr11:9010492 NRIP3 0.47 8.62 0.43 2.64e-16 Hemoglobin concentration; LUSC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg06618935 chr21:46677482 NA -0.39 -7.84 -0.39 6.23e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12801636 0.512 rs12420618 chr11:65412974 C/G cg24147428 chr11:65409760 SIPA1 -0.51 -5.89 -0.31 9.41e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg08048268 chr3:133502702 NA -0.4 -7.25 -0.37 2.99e-12 Iron status biomarkers; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.3 -5.69 -0.3 2.85e-8 Lymphocyte counts; LUSC cis rs7582180 0.874 rs13031270 chr2:100896311 G/T cg08017756 chr2:100939284 LONRF2 -0.36 -6.01 -0.31 4.77e-9 Intelligence (multi-trait analysis); LUSC trans rs877282 0.945 rs17293517 chr10:778770 C/T cg13042288 chr15:90349979 ANPEP -0.49 -7.08 -0.36 8.42e-12 Uric acid levels; LUSC cis rs17253792 0.749 rs17747301 chr14:56125030 C/G cg01858014 chr14:56050164 KTN1 -0.8 -6.58 -0.34 1.79e-10 Putamen volume; LUSC cis rs6961069 0.777 rs2366855 chr7:80253455 A/T cg04458919 chr7:80252533 CD36 -0.35 -6.27 -0.32 1.1e-9 Platelet count; LUSC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Parkinson's disease; LUSC cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg18200150 chr17:30822561 MYO1D -0.3 -5.82 -0.3 1.4e-8 Schizophrenia; LUSC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg14664628 chr15:75095509 CSK -0.57 -8.94 -0.44 2.68e-17 Breast cancer; LUSC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg06740227 chr12:86229804 RASSF9 -0.46 -7.46 -0.38 7.4e-13 Major depressive disorder; LUSC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg26818010 chr10:134567672 INPP5A -0.87 -10.92 -0.51 6.28e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg09626299 chr10:82213104 TSPAN14 -0.2 -6.01 -0.31 4.78e-9 Post bronchodilator FEV1; LUSC cis rs3820068 0.608 rs7514858 chr1:16035246 G/A cg24675056 chr1:15929824 NA 0.41 6.84 0.35 3.9e-11 Systolic blood pressure; LUSC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9814567 0.712 rs4245905 chr3:134328864 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3087591 0.960 rs2905797 chr17:29537458 G/C cg24425628 chr17:29625626 OMG;NF1 0.6 8.86 0.44 4.68e-17 Hip circumference; LUSC cis rs6736093 0.966 rs34527376 chr2:112755699 C/T cg12686935 chr2:112915763 FBLN7 -0.37 -6.06 -0.31 3.65e-9 Coronary artery disease; LUSC cis rs12579753 1.000 rs7300900 chr12:82166821 G/T cg07988820 chr12:82153109 PPFIA2 -0.44 -6.21 -0.32 1.57e-9 Resting heart rate; LUSC cis rs9814567 0.752 rs4605591 chr3:134328361 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.37 -0.56 3.42e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1801251 0.964 rs6748027 chr2:233629552 T/C cg25237894 chr2:233734115 C2orf82 0.35 6.59 0.34 1.69e-10 Coronary artery disease; LUSC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs561341 0.609 rs739800 chr17:30190083 T/A cg00745463 chr17:30367425 LRRC37B 0.63 7.58 0.38 3.37e-13 Hip circumference adjusted for BMI; LUSC trans rs8002861 0.967 rs7983109 chr13:44484351 C/A cg12856521 chr11:46389249 DGKZ 0.41 6.38 0.33 6.02e-10 Leprosy; LUSC trans rs4734806 0.579 rs72677049 chr8:105871357 T/C cg19267248 chr12:98849532 NA 0.39 6.06 0.31 3.72e-9 Periodontitis (DPAL); LUSC cis rs977987 0.581 rs8056141 chr16:75497162 A/T cg03315344 chr16:75512273 CHST6 0.51 9.38 0.46 1.04e-18 Dupuytren's disease; LUSC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg13126279 chr21:47581558 C21orf56 0.41 5.86 0.31 1.08e-8 Testicular germ cell tumor; LUSC cis rs7918232 0.556 rs788209 chr10:27434716 G/T cg14240646 chr10:27532245 ACBD5 -0.88 -8.77 -0.43 9.31e-17 Breast cancer; LUSC cis rs4622329 0.636 rs10860812 chr12:102288370 A/G cg23541617 chr12:102225335 GNPTAB -0.27 -6.02 -0.31 4.52e-9 Systemic lupus erythematosus; LUSC cis rs6500602 0.702 rs2270366 chr16:4558615 A/G cg08645402 chr16:4508243 NA -0.49 -8.51 -0.42 6.01e-16 Schizophrenia; LUSC cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg23788917 chr6:8435910 SLC35B3 0.53 7.81 0.39 7.51e-14 Motion sickness; LUSC cis rs8072100 1.000 rs8072100 chr17:45674687 A/T cg08085267 chr17:45401833 C17orf57 0.61 10.3 0.49 8.8e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg25072359 chr17:41440525 NA 0.65 9.19 0.45 4.21e-18 Menopause (age at onset); LUSC cis rs2274273 0.624 rs7152390 chr14:55811701 C/T cg04306507 chr14:55594613 LGALS3 0.48 9.46 0.46 5.53e-19 Protein biomarker; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.3 0.56 6.25e-29 Prudent dietary pattern; LUSC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg25036284 chr2:26402008 FAM59B -0.68 -9.56 -0.46 2.62e-19 Gut microbiome composition (summer); LUSC cis rs6121246 0.529 rs41310803 chr20:30452709 A/G cg13852791 chr20:30311386 BCL2L1 0.6 6.22 0.32 1.45e-9 Mean corpuscular hemoglobin; LUSC cis rs2455601 1.000 rs56336128 chr11:8908299 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.5 -7.68 -0.39 1.81e-13 Schizophrenia; LUSC cis rs2667011 0.697 rs2667002 chr2:160856492 C/T cg06573604 chr2:160760825 LY75 -0.5 -6.31 -0.33 8.89e-10 Bilirubin levels; LUSC cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg07148914 chr20:33460835 GGT7 0.54 8.4 0.42 1.33e-15 Height; LUSC cis rs9486719 1.000 rs11153023 chr6:96968525 C/T cg06623918 chr6:96969491 KIAA0776 -0.83 -9.99 -0.48 9.96e-21 Migraine;Coronary artery disease; LUSC cis rs977987 0.806 rs11860284 chr16:75412907 A/G cg04384234 chr16:75411784 CFDP1 -0.44 -7.26 -0.37 2.79e-12 Dupuytren's disease; LUSC cis rs4073582 0.595 rs2508657 chr11:66043898 G/A cg16950941 chr11:66035639 RAB1B 0.53 7.8 0.39 7.78e-14 Gout; LUSC cis rs9611519 0.894 rs4821990 chr22:41438710 A/C cg13813247 chr22:41461852 NA -0.36 -6.45 -0.33 3.82e-10 Neuroticism; LUSC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg19468946 chr17:37922297 IKZF3 -0.43 -6.79 -0.35 5.22e-11 Self-reported allergy; LUSC cis rs881375 0.678 rs2269060 chr9:123683569 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.35 0.33 6.88e-10 Rheumatoid arthritis; LUSC cis rs1728785 0.901 rs1728797 chr16:68570989 A/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.88 0.31 9.74e-9 Menopause (age at onset); LUSC cis rs9921338 0.961 rs72773833 chr16:11413274 G/A cg00044050 chr16:11439710 C16orf75 -0.49 -6.69 -0.34 9.14e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC trans rs984440 0.621 rs12550578 chr8:139078255 A/G cg03334052 chr1:168888044 NA -0.41 -6.51 -0.34 2.79e-10 Obesity-related traits; LUSC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.52 -7.96 -0.4 2.66e-14 Parkinson's disease; LUSC cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg05535760 chr7:792225 HEATR2 0.78 9.06 0.44 1.09e-17 Cerebrospinal P-tau181p levels; LUSC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg24110177 chr3:50126178 RBM5 -0.55 -9.03 -0.44 1.35e-17 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg06134567 chr22:46658398 PKDREJ -0.53 -5.93 -0.31 7.54e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6977660 0.714 rs34451907 chr7:19824538 A/G cg05791153 chr7:19748676 TWISTNB 0.68 7.08 0.36 8.71e-12 Thyroid stimulating hormone; LUSC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg12639453 chr1:2035780 PRKCZ 0.3 6.24 0.32 1.36e-9 Height; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.66 10.01 0.48 8.59e-21 Lymphocyte counts; LUSC cis rs2446066 0.872 rs111939932 chr12:53843771 C/T cg20730629 chr12:53886622 MAP3K12 -0.43 -5.79 -0.3 1.63e-8 Red blood cell count; LUSC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.33 5.93 0.31 7.6e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg03929089 chr4:120376271 NA 0.83 11.27 0.52 3.58e-25 Coronary artery disease; LUSC cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.53 0.38 4.89e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg04155289 chr7:94953770 PON1 -0.34 -5.83 -0.3 1.33e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.3 0.53 2.83e-25 Prudent dietary pattern; LUSC cis rs2115536 1.000 rs2903105 chr15:80189523 C/G cg00225070 chr15:80189496 MTHFS 0.62 9.63 0.47 1.61e-19 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9921338 0.923 rs72771877 chr16:11368616 T/A cg00044050 chr16:11439710 C16orf75 -0.5 -6.75 -0.35 6.68e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs9311676 0.632 rs57700771 chr3:58360327 G/A cg26110898 chr3:58419937 PDHB 0.41 6.64 0.34 1.28e-10 Systemic lupus erythematosus; LUSC cis rs1728785 0.818 rs12926059 chr16:68569459 T/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs7095944 0.614 rs7099316 chr10:126469005 G/A cg08799069 chr10:126477246 METTL10 -0.43 -6.74 -0.35 7.17e-11 Asthma; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg22903657 chr4:1355424 KIAA1530 -0.4 -7.04 -0.36 1.11e-11 Longevity; LUSC cis rs6964587 0.621 rs39744 chr7:92043016 A/G cg17063962 chr7:91808500 NA 0.49 7.59 0.38 3.1400000000000003e-13 Breast cancer; LUSC cis rs2898681 0.519 rs73814886 chr4:53733251 C/T cg00791764 chr4:53727839 RASL11B 0.56 7.73 0.39 1.31e-13 Optic nerve measurement (cup area); LUSC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11890956 chr21:40555474 PSMG1 -0.88 -15.38 -0.64 9.98e-41 Cognitive function; LUSC cis rs738322 0.511 rs2267371 chr22:38577119 T/G cg17652424 chr22:38574118 PLA2G6 -0.3 -6.1 -0.32 3e-9 Cutaneous nevi; LUSC cis rs9814567 1.000 rs11708531 chr3:134224902 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.7 -0.6 3.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg23978390 chr7:1156363 C7orf50 0.42 5.9 0.31 8.96e-9 Longevity;Endometriosis; LUSC cis rs10761482 0.769 rs990685 chr10:62098149 C/T cg18175470 chr10:62150864 ANK3 -0.5 -7.06 -0.36 9.52e-12 Schizophrenia; LUSC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg05802129 chr4:122689817 NA -0.37 -6.62 -0.34 1.44e-10 Type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23247000 chr7:138794512 ZC3HAV1 0.36 6.06 0.31 3.6e-9 Triglycerides; LUSC cis rs11608355 1.000 rs2075439 chr12:109859374 A/G cg05360138 chr12:110035743 NA 0.46 6.34 0.33 7.51e-10 Neuroticism; LUSC cis rs6500602 1.000 rs7204827 chr16:4467533 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.44 5.7 0.3 2.69e-8 Schizophrenia; LUSC cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg26513180 chr16:89883248 FANCA 0.79 6.36 0.33 6.64e-10 Skin colour saturation; LUSC cis rs80282103 0.867 rs7075830 chr10:1091650 G/C cg18964960 chr10:1102726 WDR37 0.7 6.34 0.33 7.58e-10 Glomerular filtration rate (creatinine); LUSC cis rs7589342 0.839 rs6747023 chr2:106431856 A/G cg14210321 chr2:106509881 NCK2 -0.53 -7.92 -0.4 3.47e-14 Addiction; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11236850 chr4:8443022 ACOX3 -0.42 -6.07 -0.32 3.39e-9 Hepatitis; LUSC trans rs877282 0.898 rs71489279 chr10:760510 T/C cg22713356 chr15:30763199 NA 1.01 14.04 0.61 1.57e-35 Uric acid levels; LUSC cis rs4423214 0.515 rs4944042 chr11:71118788 C/A cg05163923 chr11:71159392 DHCR7 0.5 7.26 0.37 2.67e-12 Vitamin D levels; LUSC cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg11266682 chr4:10021025 SLC2A9 0.53 10.0 0.48 9.14e-21 Bone mineral density; LUSC cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg07606381 chr6:8435919 SLC35B3 0.72 12.3 0.56 6.22e-29 Motion sickness; LUSC cis rs16866061 0.926 rs17479770 chr2:225335814 A/G cg12698349 chr2:225449008 CUL3 0.87 13.94 0.61 3.78e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs1997103 1.000 rs2331064 chr7:55408610 C/G cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg09904177 chr6:26538194 HMGN4 0.43 6.45 0.33 3.91e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4654899 0.828 rs6668591 chr1:21066557 A/G cg01072550 chr1:21505969 NA -0.47 -7.06 -0.36 9.47e-12 Superior frontal gyrus grey matter volume; LUSC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.22 -0.32 1.49e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15664640 chr17:80829946 TBCD -0.74 -12.62 -0.57 4.15e-30 Breast cancer; LUSC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg21028142 chr17:79581711 NPLOC4 -0.33 -7.64 -0.39 2.3e-13 Eye color traits; LUSC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg13939156 chr17:80058883 NA -0.33 -6.6 -0.34 1.59e-10 Life satisfaction; LUSC trans rs61931739 0.892 rs73309466 chr12:34093146 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.89 -0.4 4.29e-14 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22346581 chr8:107282483 OXR1 -0.4 -6.0 -0.31 5.15e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg03351412 chr1:154909251 PMVK 0.55 8.7 0.43 1.52e-16 Prostate cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20000099 chr19:33864973 CEBPG -0.43 -6.54 -0.34 2.33e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10911232 0.507 rs6668980 chr1:183018857 T/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.9 0.51 6.98e-24 Hypertriglyceridemia; LUSC cis rs829883 0.738 rs249846 chr12:98868739 T/C cg25150519 chr12:98850993 NA 0.79 13.64 0.6 5.53e-34 Colorectal adenoma (advanced); LUSC cis rs911555 0.504 rs61995761 chr14:104075712 T/C cg24130564 chr14:104152367 KLC1 -0.7 -11.34 -0.53 1.9e-25 Intelligence (multi-trait analysis); LUSC trans rs9393777 0.920 rs55834529 chr6:27072542 A/G cg01620082 chr3:125678407 NA -0.75 -6.29 -0.33 9.67e-10 Intelligence (multi-trait analysis); LUSC cis rs4776059 1.000 rs10851521 chr15:52942111 G/A cg22715398 chr15:52968154 KIAA1370 -0.64 -9.13 -0.45 6.58e-18 Schizophrenia; LUSC cis rs3093024 0.935 rs10946216 chr6:167538897 T/C cg07741184 chr6:167504864 NA -0.48 -8.4 -0.42 1.32e-15 Rheumatoid arthritis; LUSC cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.42 0.64 7e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs911119 1.000 rs6114209 chr20:23622266 G/C cg16589663 chr20:23618590 CST3 0.62 7.63 0.39 2.56e-13 Chronic kidney disease; LUSC cis rs7267979 0.966 rs6037103 chr20:25369095 A/G cg08601574 chr20:25228251 PYGB -0.44 -6.79 -0.35 5.29e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7809950 1.000 rs2894475 chr7:107262558 A/T cg23024343 chr7:107201750 COG5 -0.49 -7.85 -0.39 5.76e-14 Coronary artery disease; LUSC trans rs12310956 0.510 rs7965329 chr12:33868199 C/A cg26384229 chr12:38710491 ALG10B 0.56 8.61 0.43 3.03e-16 Morning vs. evening chronotype; LUSC cis rs1957429 0.614 rs73279833 chr14:65352523 A/G cg23373153 chr14:65346875 NA -0.99 -8.98 -0.44 1.97e-17 Pediatric areal bone mineral density (radius); LUSC trans rs1493916 0.744 rs7504560 chr18:31312148 A/G cg13755796 chr4:20253514 NA -0.41 -6.29 -0.33 1.01e-9 Life satisfaction; LUSC cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg18681998 chr4:17616180 MED28 0.88 16.23 0.66 4.6e-44 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.14 -0.32 2.31e-9 Menopause (age at onset); LUSC cis rs1018836 0.923 rs7013893 chr8:91563137 G/A cg16814680 chr8:91681699 NA -0.75 -12.48 -0.56 1.29e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9611519 0.780 rs9611542 chr22:41677317 C/T cg03806693 chr22:41940476 POLR3H -0.59 -8.61 -0.43 2.85e-16 Neuroticism; LUSC trans rs13390641 0.614 rs10496374 chr2:104079777 C/T cg03260781 chr1:16346299 HSPB7 0.47 6.36 0.33 6.58e-10 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs921968 0.643 rs1055816 chr2:219501328 G/A cg02176678 chr2:219576539 TTLL4 0.59 10.82 0.51 1.36e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs9517313 0.591 rs9554480 chr13:99221138 T/A cg20487152 chr13:99095054 FARP1 -0.41 -6.83 -0.35 4.14e-11 Neuroticism; LUSC cis rs2204008 0.623 rs1663281 chr12:38120936 A/G cg26384229 chr12:38710491 ALG10B -0.68 -10.45 -0.5 2.62e-22 Bladder cancer; LUSC cis rs3733585 0.699 rs60045583 chr4:9971950 G/A cg11266682 chr4:10021025 SLC2A9 -0.52 -9.64 -0.47 1.46e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.77 0.35 5.68e-11 Tonsillectomy; LUSC cis rs654950 0.901 rs594656 chr1:41999873 C/T cg06885757 chr1:42089581 HIVEP3 -0.45 -8.56 -0.42 4.1e-16 Airway imaging phenotypes; LUSC cis rs9768139 0.708 rs10262596 chr7:158114495 G/A cg24154853 chr7:158122151 PTPRN2 0.45 8.8 0.43 7.55e-17 Calcium levels; LUSC cis rs4363385 0.776 rs2879490 chr1:152947163 A/G cg07796016 chr1:152779584 LCE1C -0.47 -6.65 -0.34 1.23e-10 Inflammatory skin disease; LUSC cis rs921665 0.748 rs1869421 chr2:3202068 G/T cg16434511 chr2:3151078 NA -0.58 -5.93 -0.31 7.76e-9 World class endurance athleticism; LUSC cis rs713587 0.713 rs4665276 chr2:25213333 C/T cg15423357 chr2:25149977 NA -0.37 -7.34 -0.37 1.66e-12 Body mass index in non-asthmatics; LUSC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.35 0.42 1.88e-15 Hemoglobin concentration; LUSC trans rs6502050 0.835 rs67106357 chr17:80116826 T/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11890956 chr21:40555474 PSMG1 1.04 21.33 0.76 2.7e-64 Cognitive function; LUSC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg03676636 chr4:99064102 C4orf37 0.35 7.61 0.38 2.85e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs62103177 0.810 rs62103175 chr18:77622467 C/T cg14227996 chr4:17616232 MED28 0.8 8.1 0.41 1.06e-14 Opioid sensitivity; LUSC cis rs7267979 0.549 rs6138537 chr20:25184466 A/G cg08601574 chr20:25228251 PYGB 0.5 7.81 0.39 7.27e-14 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9329221 0.621 rs12156350 chr8:10268516 T/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.2 -0.37 3.96e-12 Neuroticism; LUSC cis rs6733011 0.578 rs6714243 chr2:99510039 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.12 -0.36 6.86e-12 Bipolar disorder; LUSC cis rs1559088 0.842 rs12977993 chr19:33580453 T/A cg27124370 chr19:33622961 WDR88 0.58 7.63 0.39 2.56e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.45 -0.33 3.84e-10 Total body bone mineral density; LUSC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg01341218 chr17:43662625 NA -0.73 -10.61 -0.5 7.68e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.17 0.41 6.27e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8078723 1.000 rs6503530 chr17:38161823 T/C cg17467752 chr17:38218738 THRA 0.77 12.45 0.56 1.7e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.42 0.42 1.09e-15 Prudent dietary pattern; LUSC cis rs4363385 0.747 rs6587716 chr1:152966705 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.61 -0.38 2.77e-13 Inflammatory skin disease; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.51e-15 Axial length; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18755653 chr4:108910870 HADH -0.44 -6.49 -0.33 3.19e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9291683 0.507 rs3775940 chr4:10025163 A/T cg26043149 chr18:55253948 FECH 0.47 7.12 0.36 6.68e-12 Bone mineral density; LUSC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg05535760 chr7:792225 HEATR2 0.78 9.17 0.45 5.01e-18 Cerebrospinal P-tau181p levels; LUSC cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg25809561 chr17:30822961 MYO1D -0.38 -6.4 -0.33 5.31e-10 Schizophrenia; LUSC trans rs7615952 0.641 rs7632497 chr3:125783086 A/C cg07211511 chr3:129823064 LOC729375 -0.75 -9.81 -0.47 4.1e-20 Blood pressure (smoking interaction); LUSC cis rs7071206 0.898 rs28706743 chr10:79394329 T/G cg07817648 chr10:79422355 NA -0.59 -7.51 -0.38 5.33e-13 Bone mineral density; LUSC cis rs3126085 0.935 rs4634913 chr1:152249932 T/C cg26876637 chr1:152193138 HRNR 0.46 6.38 0.33 6.03e-10 Atopic dermatitis; LUSC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.53 -7.18 -0.37 4.47e-12 Renal function-related traits (BUN); LUSC cis rs10464366 0.510 rs62442212 chr7:39146896 A/C cg21665744 chr7:39171113 POU6F2 0.45 7.34 0.37 1.64e-12 IgG glycosylation; LUSC cis rs13006833 0.668 rs2136566 chr2:191141283 C/T cg21644426 chr2:191273491 MFSD6 0.47 6.58 0.34 1.86e-10 Urinary metabolites; LUSC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg12639453 chr1:2035780 PRKCZ 0.29 6.29 0.33 9.71e-10 Height; LUSC cis rs4595586 0.545 rs7970850 chr12:39397878 T/C cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC trans rs1945213 0.694 rs34537090 chr11:55843285 G/C cg03929089 chr4:120376271 NA 0.69 7.76 0.39 1.06e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg07148914 chr20:33460835 GGT7 -0.42 -6.25 -0.32 1.26e-9 Coronary artery disease; LUSC cis rs11190604 1.000 rs7088512 chr10:102303498 G/T cg23241863 chr10:102295624 HIF1AN 0.46 5.73 0.3 2.22e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2835872 0.869 rs73203821 chr21:39046744 C/T cg20424643 chr21:39039972 KCNJ6 0.51 7.58 0.38 3.38e-13 Electroencephalographic traits in alcoholism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24830314 chr6:83775579 UBE2CBP -0.51 -6.04 -0.31 4.18e-9 Bipolar disorder and schizophrenia; LUSC trans rs61931739 0.517 rs7958755 chr12:34294699 T/C cg26384229 chr12:38710491 ALG10B 0.72 11.71 0.54 9.17e-27 Morning vs. evening chronotype; LUSC cis rs6426558 0.537 rs488104 chr1:227300277 G/A cg10327440 chr1:227177885 CDC42BPA 0.54 7.39 0.37 1.18e-12 Neutrophil percentage of white cells; LUSC cis rs763121 0.853 rs10135 chr22:39082174 C/T cg06544989 chr22:39130855 UNC84B -0.39 -7.08 -0.36 8.37e-12 Menopause (age at onset); LUSC cis rs7202877 0.656 rs8048677 chr16:75392028 C/G cg03315344 chr16:75512273 CHST6 0.44 6.47 0.33 3.59e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg07092213 chr7:1199455 ZFAND2A -0.53 -8.68 -0.43 1.76e-16 Longevity;Endometriosis; LUSC trans rs1005277 0.579 rs2474569 chr10:38383491 C/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.57 -0.46 2.51e-19 Extrinsic epigenetic age acceleration; LUSC trans rs35110281 0.712 rs1454648 chr21:45053815 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.7 12.83 0.57 6.7e-31 Mean corpuscular volume; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg07217954 chr7:1067459 C7orf50 0.52 5.67 0.3 3.02e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg03609598 chr5:56110824 MAP3K1 -0.41 -6.09 -0.32 3.02e-9 Initial pursuit acceleration; LUSC cis rs12681288 0.963 rs7822955 chr8:1029090 C/T cg04851639 chr8:1020857 NA 0.31 6.14 0.32 2.37e-9 Schizophrenia; LUSC cis rs7264396 0.623 rs2425123 chr20:34329547 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.26 -0.41 3.35e-15 Total cholesterol levels; LUSC cis rs7707921 0.881 rs2407153 chr5:81555328 T/G cg15871215 chr5:81402204 ATG10 0.43 6.14 0.32 2.29e-9 Breast cancer; LUSC cis rs897080 0.515 rs1067366 chr2:44655094 T/C cg00619915 chr2:44497795 NA -0.41 -6.14 -0.32 2.36e-9 Height; LUSC cis rs11030122 0.632 rs10835556 chr11:4083013 A/G cg08557956 chr11:4115526 RRM1 -0.46 -6.0 -0.31 5.25e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.02 -0.31 4.47e-9 Huntington's disease progression; LUSC cis rs6977660 1.000 rs2892940 chr7:19794750 G/A cg07541023 chr7:19748670 TWISTNB 0.59 6.72 0.35 7.84e-11 Thyroid stimulating hormone; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 14.72 0.63 3.88e-38 Platelet count; LUSC cis rs9527 0.615 rs2152915 chr10:104691732 A/T cg05855489 chr10:104503620 C10orf26 0.52 8.08 0.4 1.19e-14 Arsenic metabolism; LUSC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg26441486 chr22:50317300 CRELD2 0.49 7.28 0.37 2.45e-12 Schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17658546 chr4:90032747 TIGD2 -0.49 -6.59 -0.34 1.75e-10 Hepatitis; LUSC trans rs12579753 0.956 rs34146892 chr12:82188581 T/G cg07923666 chr12:49932857 KCNH3 -0.52 -6.48 -0.33 3.31e-10 Resting heart rate; LUSC cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg15423357 chr2:25149977 NA 0.43 8.71 0.43 1.4e-16 Body mass index; LUSC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg14829155 chr15:31115871 NA -0.57 -7.96 -0.4 2.7e-14 Huntington's disease progression; LUSC cis rs4595586 0.545 rs11615718 chr12:39395335 A/G cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.59 0.38 3.32e-13 Bipolar disorder; LUSC cis rs6545883 0.894 rs2167566 chr2:61519408 G/T cg15711740 chr2:61764176 XPO1 -0.44 -6.99 -0.36 1.49e-11 Tuberculosis; LUSC cis rs68170813 0.559 rs4515482 chr7:107072681 A/C cg02696742 chr7:106810147 HBP1 -0.61 -8.96 -0.44 2.35e-17 Coronary artery disease; LUSC cis rs9911578 1.000 rs12938772 chr17:56776320 T/C cg12560992 chr17:57184187 TRIM37 0.83 15.01 0.63 2.71e-39 Intelligence (multi-trait analysis); LUSC cis rs9640161 0.830 rs1051764 chr7:150070663 T/C cg10018233 chr7:150070692 REPIN1 0.45 9.1 0.45 8.14e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg10802521 chr3:52805072 NEK4 -0.54 -8.7 -0.43 1.54e-16 Intelligence (multi-trait analysis); LUSC cis rs9388451 0.868 rs10457467 chr6:126045148 T/A cg05901451 chr6:126070800 HEY2 -0.92 -17.95 -0.7 6.65e-51 Brugada syndrome; LUSC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg04455712 chr21:45112962 RRP1B 0.46 8.8 0.43 7.66e-17 Mean corpuscular volume; LUSC cis rs3818285 0.504 rs1973972 chr10:111651133 A/T cg00817464 chr10:111662876 XPNPEP1 0.6 8.63 0.43 2.53e-16 Superior crus of antihelix expression; LUSC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg04871131 chr7:94954202 PON1 -0.39 -6.14 -0.32 2.41e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg26384229 chr12:38710491 ALG10B 0.89 14.82 0.63 1.52e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs2130392 0.962 rs13132498 chr4:185611454 T/C cg04058563 chr4:185651563 MLF1IP -0.44 -7.18 -0.37 4.62e-12 Kawasaki disease; LUSC cis rs2236918 1.000 rs1635509 chr1:242028027 C/T cg17736920 chr1:242011382 EXO1 0.43 6.85 0.35 3.62e-11 Menopause (age at onset); LUSC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.63 -9.26 -0.45 2.61e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7582180 0.764 rs1530028 chr2:100927910 A/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.69 -0.43 1.65e-16 Intelligence (multi-trait analysis); LUSC cis rs12760731 0.720 rs10913540 chr1:178340060 T/C cg00404053 chr1:178313656 RASAL2 0.62 6.45 0.33 3.85e-10 Obesity-related traits; LUSC cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg02380750 chr20:61661411 NA 0.33 5.77 0.3 1.81e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs909002 0.789 rs2139539 chr1:32117779 C/T cg01639898 chr1:32083012 HCRTR1 0.3 7.59 0.38 3.25e-13 Intelligence (multi-trait analysis); LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg14196790 chr5:131705035 SLC22A5 0.43 7.17 0.37 4.76e-12 Blood metabolite levels; LUSC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 12.81 0.57 7.9e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11168618 0.875 rs11168606 chr12:48892689 G/T cg24011408 chr12:48396354 COL2A1 0.39 6.25 0.32 1.22e-9 Adiponectin levels; LUSC cis rs727505 0.954 rs59673207 chr7:124596982 G/C cg23710748 chr7:124431027 NA -0.38 -6.6 -0.34 1.58e-10 Lewy body disease; LUSC cis rs10754283 0.934 rs10754284 chr1:90113702 A/C cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.73 -0.39 1.31e-13 Lymphocyte counts; LUSC cis rs11051970 0.879 rs950080 chr12:32588503 G/A cg24626660 chr12:32551988 NA 0.33 5.66 0.3 3.2e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs738322 1.000 rs738322 chr22:38569006 A/G cg25457927 chr22:38595422 NA -0.42 -8.93 -0.44 2.89e-17 Cutaneous nevi; LUSC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -6.99 -0.36 1.51e-11 Intelligence (multi-trait analysis); LUSC cis rs12493885 0.585 rs701264 chr3:153628080 A/G cg17054900 chr3:154042577 DHX36 -0.59 -6.07 -0.32 3.51e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12950390 0.893 rs12325760 chr17:45840886 C/T cg06532163 chr17:45867833 NA 0.34 6.23 0.32 1.41e-9 IgG glycosylation; LUSC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg17264618 chr3:40429014 ENTPD3 0.36 7.47 0.38 6.9e-13 Renal cell carcinoma; LUSC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11644478 chr21:40555479 PSMG1 0.84 14.13 0.61 7.18e-36 Cognitive function; LUSC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg12311346 chr5:56204834 C5orf35 0.83 13.38 0.59 5.6e-33 Initial pursuit acceleration; LUSC cis rs77216612 0.840 rs11055030 chr12:12878349 G/C cg04607235 chr12:12878440 APOLD1 -0.95 -15.62 -0.65 1.15e-41 Lymphocyte counts; LUSC cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.66 -11.27 -0.53 3.39e-25 Personality dimensions; LUSC trans rs1005277 0.579 rs2505197 chr10:38393310 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.4 0.38 1.15e-12 Schizophrenia; LUSC cis rs10782582 0.593 rs12131344 chr1:76136437 C/T cg22875332 chr1:76189707 ACADM -0.41 -5.81 -0.3 1.43e-8 Daytime sleep phenotypes; LUSC cis rs6582630 0.519 rs11495699 chr12:38286219 G/T cg13010199 chr12:38710504 ALG10B 0.7 10.91 0.51 6.68e-24 Drug-induced liver injury (flucloxacillin); LUSC cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg07424592 chr7:64974309 NA 0.71 6.19 0.32 1.72e-9 Diabetic kidney disease; LUSC cis rs6967385 0.934 rs2098364 chr7:12368783 C/A cg06484146 chr7:12443880 VWDE 0.42 6.15 0.32 2.26e-9 Response to taxane treatment (placlitaxel); LUSC cis rs9549367 0.789 rs7994324 chr13:113906497 T/C cg00898013 chr13:113819073 PROZ -0.55 -7.91 -0.4 3.91e-14 Platelet distribution width; LUSC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11890956 chr21:40555474 PSMG1 1.03 21.12 0.76 1.7e-63 Cognitive function; LUSC cis rs8141529 0.764 rs5762854 chr22:29246278 T/C cg02153584 chr22:29168773 CCDC117 0.62 9.67 0.47 1.13e-19 Lymphocyte counts; LUSC cis rs7072216 0.881 rs2147896 chr10:100148176 A/G cg26618903 chr10:100175079 PYROXD2 -0.3 -5.78 -0.3 1.74e-8 Metabolite levels; LUSC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg07414643 chr4:187882934 NA 0.56 10.64 0.5 5.99e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs6845621 0.717 rs1518002 chr4:18843657 G/A cg12196642 chr4:18937545 NA -0.32 -5.8 -0.3 1.53e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs6121246 0.609 rs6089054 chr20:30323141 A/G cg13852791 chr20:30311386 BCL2L1 0.93 14.15 0.61 6.1e-36 Mean corpuscular hemoglobin; LUSC cis rs10979 0.597 rs9496685 chr6:143908690 G/A cg25407410 chr6:143891975 LOC285740 -0.65 -8.17 -0.41 6.6e-15 Hypospadias; LUSC cis rs1865760 0.516 rs9358903 chr6:26061949 A/C cg17691542 chr6:26056736 HIST1H1C 0.53 8.09 0.4 1.1e-14 Height; LUSC cis rs3820068 0.608 rs7519899 chr1:16045579 A/G cg24675056 chr1:15929824 NA 0.42 6.82 0.35 4.36e-11 Systolic blood pressure; LUSC cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg02380750 chr20:61661411 NA 0.34 5.89 0.31 9.22e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7605827 0.930 rs12692261 chr2:15511967 T/G cg19274914 chr2:15703543 NA 0.46 8.95 0.44 2.45e-17 Educational attainment (years of education); LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg15112475 chr7:1198522 ZFAND2A -0.34 -7.27 -0.37 2.63e-12 Longevity;Endometriosis; LUSC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.03e-10 Blood pressure (smoking interaction); LUSC cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg03060546 chr3:49711283 APEH 0.65 7.31 0.37 1.97e-12 Menarche (age at onset); LUSC cis rs6496667 0.557 rs2601201 chr15:90958000 C/T cg22089800 chr15:90895588 ZNF774 0.56 8.06 0.4 1.36e-14 Rheumatoid arthritis; LUSC cis rs9674544 0.757 rs6504593 chr17:47132819 T/C cg10950924 chr17:47092072 IGF2BP1 -0.37 -5.83 -0.3 1.33e-8 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); LUSC cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg22467129 chr15:76604101 ETFA -0.45 -6.99 -0.36 1.51e-11 Blood metabolite levels; LUSC cis rs8092503 1.000 rs1819886 chr18:52493622 A/G cg12377874 chr18:52495404 RAB27B 0.34 6.14 0.32 2.38e-9 Childhood body mass index; LUSC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg17971929 chr21:40555470 PSMG1 -0.52 -7.52 -0.38 5.25e-13 Menarche (age at onset); LUSC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg03213289 chr20:61660250 NA 0.67 13.96 0.61 3.26e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg05665937 chr4:1216051 CTBP1 0.36 5.69 0.3 2.8e-8 Obesity-related traits; LUSC cis rs1003719 0.654 rs764175 chr21:38517058 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.52 -0.5 1.49e-22 Eye color traits; LUSC cis rs6987853 0.966 rs2923428 chr8:42388301 T/C cg09913449 chr8:42400586 C8orf40 0.49 8.29 0.41 2.78e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs1994135 0.692 rs1579909 chr12:33694780 T/C cg06521331 chr12:34319734 NA -0.39 -5.83 -0.3 1.33e-8 Resting heart rate; LUSC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg06544989 chr22:39130855 UNC84B 0.34 5.8 0.3 1.54e-8 Menopause (age at onset); LUSC cis rs2898290 0.540 rs35005793 chr8:11450472 G/A cg27411982 chr8:10470053 RP1L1 0.38 5.81 0.3 1.48e-8 Systolic blood pressure; LUSC trans rs208520 1.000 rs12190773 chr6:66968194 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.34 0.56 4.42e-29 Exhaled nitric oxide output; LUSC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg05340658 chr4:99064831 C4orf37 0.68 11.69 0.54 1.03e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg14500267 chr11:67383377 NA 0.35 6.66 0.34 1.14e-10 Mean corpuscular volume; LUSC cis rs11792861 0.589 rs75742991 chr9:111929624 C/G cg05043794 chr9:111880884 C9orf5 -0.36 -7.45 -0.38 7.86e-13 Menarche (age at onset); LUSC cis rs9815354 0.951 rs12492599 chr3:42005734 C/A cg03022575 chr3:42003672 ULK4 -0.51 -5.79 -0.3 1.64e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg16434002 chr17:42200994 HDAC5 -0.45 -6.32 -0.33 8.15e-10 Total body bone mineral density; LUSC cis rs9475752 1.000 rs1460561 chr6:56797574 G/T cg26366048 chr6:56820386 BEND6;DST 0.53 5.72 0.3 2.36e-8 Menarche (age at onset); LUSC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg25319279 chr11:5960081 NA 0.43 6.65 0.34 1.17e-10 DNA methylation (variation); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25417551 chr17:35767582 TADA2A;ACACA 0.41 6.01 0.31 4.94e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.76 10.52 0.5 1.53e-22 Age-related macular degeneration (geographic atrophy); LUSC cis rs1570884 0.516 rs9316462 chr13:50176321 A/G cg03651054 chr13:50194643 NA 0.36 6.23 0.32 1.38e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg18350739 chr11:68623251 NA -0.37 -6.66 -0.34 1.14e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.87 14.59 0.62 1.2e-37 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2625529 0.824 rs2306488 chr15:72292115 A/G cg16672083 chr15:72433130 SENP8 -0.52 -7.49 -0.38 6.03e-13 Red blood cell count; LUSC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg22800045 chr5:56110881 MAP3K1 0.67 9.15 0.45 5.56e-18 Initial pursuit acceleration; LUSC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10986311 0.802 rs7049097 chr9:127110457 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.47 7.54 0.38 4.57e-13 Vitiligo; LUSC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC trans rs66887589 0.616 rs7659403 chr4:120207254 T/A cg25214090 chr10:38739885 LOC399744 0.38 6.15 0.32 2.25e-9 Diastolic blood pressure; LUSC cis rs4792901 0.802 rs28636996 chr17:41572786 T/C cg22562494 chr17:41607896 ETV4 -0.33 -6.18 -0.32 1.9e-9 Dupuytren's disease; LUSC cis rs67072384 1.000 rs72964181 chr11:72440124 C/G cg04827223 chr11:72435913 ARAP1 -0.83 -7.37 -0.37 1.38e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs747782 0.527 rs3741410 chr11:48168664 A/C cg15704280 chr7:45808275 SEPT13 0.58 5.96 0.31 6.43e-9 Intraocular pressure; LUSC cis rs17253792 0.822 rs10150498 chr14:56064124 G/T cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs3892630 0.588 rs2287881 chr19:33333155 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.52 5.89 0.31 9.29e-9 Red blood cell traits; LUSC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg09877947 chr5:131593287 PDLIM4 0.49 7.93 0.4 3.22e-14 Blood metabolite levels; LUSC cis rs7605827 0.930 rs10208972 chr2:15676686 G/A cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.77e-16 Educational attainment (years of education); LUSC cis rs546131 0.890 rs485845 chr11:34830389 G/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.15 -0.32 2.23e-9 Lung disease severity in cystic fibrosis; LUSC cis rs8060686 0.516 rs9939821 chr16:68167787 T/A cg05110241 chr16:68378359 PRMT7 -0.5 -6.26 -0.32 1.17e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.18 0.37 4.46e-12 Mean platelet volume; LUSC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg03526776 chr6:41159608 TREML2 0.33 6.44 0.33 4.24e-10 Alzheimer's disease (late onset); LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs9653442 0.835 rs11694875 chr2:100732845 A/G cg22139774 chr2:100720529 AFF3 0.52 9.51 0.46 4.01e-19 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg26314531 chr2:26401878 FAM59B -0.68 -9.1 -0.45 8.35e-18 Gut microbiome composition (summer); LUSC trans rs4843747 0.671 rs4075998 chr16:88106776 G/A cg26811252 chr16:29126840 RRN3P2 0.57 9.15 0.45 5.58e-18 Menopause (age at onset); LUSC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg23262073 chr20:60523788 NA -0.44 -6.23 -0.32 1.4e-9 Body mass index; LUSC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg06484146 chr7:12443880 VWDE -0.69 -7.28 -0.37 2.41e-12 Coronary artery disease; LUSC cis rs9296092 0.538 rs62407564 chr6:33534010 C/T cg13560919 chr6:33536144 NA -0.86 -16.62 -0.67 1.25e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC trans rs61931739 0.534 rs10844828 chr12:34303109 C/T cg26384229 chr12:38710491 ALG10B 0.63 10.16 0.49 2.59e-21 Morning vs. evening chronotype; LUSC cis rs1997103 0.871 rs1997100 chr7:55399656 C/G cg17469321 chr7:55412551 NA 0.65 10.41 0.5 3.51e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs61931739 0.963 rs12307606 chr12:34016365 C/T cg06521331 chr12:34319734 NA 0.41 6.67 0.34 1.07e-10 Morning vs. evening chronotype; LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg01579765 chr21:45077557 HSF2BP 0.56 12.06 0.55 4.64e-28 Mean corpuscular volume; LUSC cis rs9329289 0.603 rs2458705 chr10:2541377 A/G cg15501526 chr10:2543763 NA 0.67 12.24 0.56 1.08e-28 Age-related hearing impairment; LUSC cis rs10493773 0.775 rs11161662 chr1:86185040 A/G cg17807903 chr1:86174739 ZNHIT6 -0.5 -12.29 -0.56 6.71e-29 Urate levels in overweight individuals; LUSC cis rs9837602 0.882 rs6807176 chr3:99760864 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.17 -0.32 1.99e-9 Breast cancer; LUSC cis rs17407555 0.606 rs3775945 chr4:10011996 A/T cg11266682 chr4:10021025 SLC2A9 -0.47 -6.21 -0.32 1.53e-9 Schizophrenia (age at onset); LUSC cis rs79349575 0.783 rs12603969 chr17:47034419 A/G cg22482690 chr17:47019901 SNF8 0.38 7.01 0.36 1.35e-11 Type 2 diabetes; LUSC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs3806843 1.000 rs10037757 chr5:140197222 G/T cg19875535 chr5:140030758 IK 0.46 7.43 0.38 8.98e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs8114671 0.562 rs6119536 chr20:33450041 A/G cg07148914 chr20:33460835 GGT7 -0.47 -7.2 -0.37 3.98e-12 Height; LUSC cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg05347473 chr6:146136440 FBXO30 0.47 7.77 0.39 9.89e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg20243544 chr17:37824526 PNMT 0.5 6.95 0.36 1.96e-11 Asthma; LUSC cis rs6545883 0.783 rs12713442 chr2:61848078 G/A cg15711740 chr2:61764176 XPO1 -0.38 -6.07 -0.32 3.5e-9 Tuberculosis; LUSC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg23093090 chr10:104574429 C10orf26 -0.38 -7.21 -0.37 3.77e-12 Reticulocyte count; LUSC cis rs7666738 0.546 rs1813970 chr4:98887167 A/G cg03676636 chr4:99064102 C4orf37 -0.3 -6.35 -0.33 7.12e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs6545883 0.894 rs778158 chr2:61555421 A/G cg15711740 chr2:61764176 XPO1 0.43 6.65 0.34 1.22e-10 Tuberculosis; LUSC cis rs9296092 0.560 rs7765393 chr6:33525598 A/T cg13560919 chr6:33536144 NA -0.84 -16.34 -0.67 1.67e-44 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7527798 0.592 rs6702222 chr1:207825627 C/T cg09232269 chr1:207846808 CR1L -0.3 -6.39 -0.33 5.46e-10 Erythrocyte sedimentation rate; LUSC cis rs4969178 0.965 rs3817295 chr17:76394526 T/A cg20026190 chr17:76395443 PGS1 0.45 8.17 0.41 6.52e-15 HDL cholesterol levels; LUSC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg26924012 chr15:45694286 SPATA5L1 1.11 20.39 0.74 1.27e-60 Homoarginine levels; LUSC trans rs481331 0.741 rs683538 chr10:43148854 A/G cg10296513 chr8:37963428 ASH2L 0.56 6.1 0.32 2.97e-9 Systemic juvenile idiopathic arthritis; LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg03934478 chr11:495069 RNH1 0.84 10.03 0.48 7.31e-21 Body mass index; LUSC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg09021430 chr5:549028 NA -0.57 -8.23 -0.41 4.36e-15 Obesity-related traits; LUSC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg25039879 chr17:56429692 SUPT4H1 0.5 7.04 0.36 1.07e-11 Cognitive test performance; LUSC cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg16386425 chr10:429943 DIP2C 0.41 5.98 0.31 5.74e-9 Psychosis in Alzheimer's disease; LUSC cis rs17270561 0.636 rs7453371 chr6:25719256 A/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.9 0.44 3.71e-17 Iron status biomarkers; LUSC cis rs1981331 1.000 rs1981331 chr21:47995443 A/C cg17243659 chr21:48055224 PRMT2 0.86 6.24 0.32 1.31e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; LUSC cis rs3820068 0.608 rs10927840 chr1:16045250 A/G cg24675056 chr1:15929824 NA 0.42 6.8 0.35 4.81e-11 Systolic blood pressure; LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg22963979 chr7:1858916 MAD1L1 -0.59 -9.39 -0.46 9.87e-19 Bipolar disorder and schizophrenia; LUSC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg09323728 chr8:95962352 TP53INP1 0.37 7.08 0.36 8.39e-12 Type 2 diabetes; LUSC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg19302996 chr17:73780495 UNK 0.47 6.9 0.35 2.6e-11 White matter hyperintensity burden; LUSC cis rs2197308 0.565 rs4123923 chr12:37857684 T/C cg13010199 chr12:38710504 ALG10B 0.7 10.86 0.51 9.83e-24 Morning vs. evening chronotype; LUSC cis rs3106136 0.967 rs61514245 chr4:95165053 C/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.08 -0.32 3.26e-9 Capecitabine sensitivity; LUSC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg03806693 chr22:41940476 POLR3H -0.99 -14.32 -0.62 1.34e-36 Vitiligo; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.89 0.55 2.01e-27 Prudent dietary pattern; LUSC cis rs870825 0.616 rs7680779 chr4:185652830 G/C cg04058563 chr4:185651563 MLF1IP -0.79 -11.92 -0.55 1.5e-27 Blood protein levels; LUSC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.11 -0.32 2.79e-9 Menopause (age at onset); LUSC cis rs738322 0.533 rs5756934 chr22:38547279 G/A cg25457927 chr22:38595422 NA -0.41 -8.04 -0.4 1.62e-14 Cutaneous nevi; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg00149659 chr3:10157352 C3orf10 0.88 12.31 0.56 5.78e-29 Alzheimer's disease; LUSC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg26384229 chr12:38710491 ALG10B -0.92 -17.71 -0.7 5.74e-50 Heart rate; LUSC cis rs4285028 0.747 rs1574133 chr3:121468794 G/C cg11130432 chr3:121712080 ILDR1 -0.52 -7.64 -0.39 2.36e-13 Multiple sclerosis; LUSC cis rs9300255 0.602 rs1790116 chr12:123618544 G/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.85 -0.3 1.17e-8 Neutrophil percentage of white cells; LUSC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs1775715 0.870 rs3847414 chr10:32219176 A/G cg03015672 chr10:32216066 ARHGAP12 0.31 5.68 0.3 2.98e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg22868518 chr11:507468 RNH1 -0.63 -5.87 -0.31 1.08e-8 Body mass index; LUSC cis rs1891275 0.515 rs6583784 chr10:93491576 A/G cg07889827 chr10:93443413 NA 0.39 8.97 0.44 2.1e-17 Intelligence (multi-trait analysis); LUSC cis rs308403 0.509 rs309379 chr4:123671456 C/G cg10495464 chr4:123653540 BBS12;LOC729338 0.97 18.46 0.71 6.18e-53 Blood protein levels; LUSC cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg00857998 chr1:205179979 DSTYK 0.62 9.69 0.47 9.86e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs870825 0.655 rs35397385 chr4:185639095 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.55 0.6 1.23e-33 Blood protein levels; LUSC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg11608241 chr8:8085544 FLJ10661 -0.39 -5.8 -0.3 1.52e-8 Mood instability; LUSC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg07424592 chr7:64974309 NA -0.64 -5.72 -0.3 2.34e-8 Diabetic kidney disease; LUSC cis rs7267979 1.000 rs2257988 chr20:25270003 T/C cg08601574 chr20:25228251 PYGB 0.43 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs3126085 0.935 rs4845421 chr1:152173259 G/T cg26876637 chr1:152193138 HRNR 0.45 6.44 0.33 4.15e-10 Atopic dermatitis; LUSC trans rs459571 0.959 rs392134 chr9:136909008 G/A cg10765909 chr12:53715428 AAAS -0.42 -5.98 -0.31 5.77e-9 Platelet distribution width; LUSC cis rs546131 1.000 rs546131 chr11:34851760 G/C cg06937548 chr11:34938143 PDHX;APIP 0.49 6.8 0.35 4.84e-11 Lung disease severity in cystic fibrosis; LUSC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg07677032 chr17:61819896 STRADA 0.55 8.97 0.44 2.18e-17 Prudent dietary pattern; LUSC cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.75 0.43 1.1e-16 Axial length; LUSC cis rs965469 1.000 rs6051807 chr20:3350485 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -5.68 -0.3 2.89e-8 IFN-related cytopenia; LUSC cis rs10435719 0.902 rs6601633 chr8:11805173 C/T cg21775007 chr8:11205619 TDH -0.47 -6.8 -0.35 4.72e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6686643 0.868 rs9333471 chr1:165619712 A/G cg16553119 chr1:165599451 MGST3 -0.42 -6.76 -0.35 6.06e-11 Total ventricular volume; LUSC cis rs6690583 1.000 rs6690464 chr1:85466369 A/G cg22153463 chr1:85462885 MCOLN2 -0.68 -8.57 -0.42 3.94e-16 Serum sulfate level; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg26354017 chr1:205819088 PM20D1 0.84 15.09 0.64 1.35e-39 Menarche (age at onset); LUSC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg12560992 chr17:57184187 TRIM37 -0.9 -17.71 -0.7 5.7e-50 Intelligence (multi-trait analysis); LUSC cis rs360798 0.512 rs4461246 chr2:63027671 C/T cg17519650 chr2:63277830 OTX1 -0.52 -7.25 -0.37 2.89e-12 Coronary artery disease; LUSC cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg10172584 chr19:19639581 YJEFN3 0.48 5.69 0.3 2.73e-8 Bipolar disorder; LUSC cis rs35146811 0.700 rs858513 chr7:99825558 G/A cg13334819 chr7:99746414 C7orf59 0.49 6.5 0.34 2.96e-10 Coronary artery disease; LUSC cis rs4727027 0.704 rs10952805 chr7:148907849 G/A cg23158103 chr7:148848205 ZNF398 -0.44 -7.18 -0.37 4.59e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9393777 0.623 rs16891717 chr6:26477143 T/A cg12826209 chr6:26865740 GUSBL1 0.68 7.67 0.39 1.85e-13 Intelligence (multi-trait analysis); LUSC cis rs10887741 1.000 rs12412482 chr10:89443799 C/T cg24243914 chr10:89418206 PAPSS2 0.32 5.9 0.31 8.84e-9 Exercise (leisure time); LUSC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg06212747 chr3:49208901 KLHDC8B 0.44 6.07 0.32 3.43e-9 Parkinson's disease; LUSC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg12560992 chr17:57184187 TRIM37 0.86 15.57 0.65 1.69e-41 Intelligence (multi-trait analysis); LUSC cis rs7089973 0.604 rs10490909 chr10:116593532 C/T cg25233709 chr10:116636983 FAM160B1 0.36 6.41 0.33 4.99e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2286885 0.965 rs741024 chr9:129251821 A/G cg15282417 chr9:129245246 FAM125B -0.36 -6.12 -0.32 2.62e-9 Intraocular pressure; LUSC cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg01256987 chr12:42539512 GXYLT1 -0.46 -8.71 -0.43 1.46e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7582180 0.629 rs10202326 chr2:100950237 A/G cg08017756 chr2:100939284 LONRF2 -0.44 -8.27 -0.41 3.33e-15 Intelligence (multi-trait analysis); LUSC cis rs941408 1.000 rs1076447 chr19:2792128 C/G cg06609049 chr19:2785107 THOP1 0.71 11.22 0.52 5.42e-25 Total cholesterol levels; LUSC cis rs79976124 0.842 rs1548154 chr6:66624910 G/A cg07460842 chr6:66804631 NA 0.66 7.94 0.4 3.02e-14 Type 2 diabetes; LUSC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.84 -0.35 3.67e-11 Total body bone mineral density; LUSC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.91 -0.44 3.3e-17 Bipolar disorder; LUSC cis rs7804356 1.000 rs3801840 chr7:26832986 A/G cg03456212 chr7:26904342 SKAP2 -0.55 -6.5 -0.33 2.98e-10 Type 1 diabetes; LUSC cis rs7043114 0.563 rs987554 chr9:95298738 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.55 -0.34 2.14e-10 Height; LUSC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 12.31 0.56 5.85e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6964587 0.773 rs10488514 chr7:91951842 C/A cg17063962 chr7:91808500 NA 0.52 7.41 0.38 1.07e-12 Breast cancer; LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg22166914 chr1:53195759 ZYG11B 0.57 9.31 0.45 1.81e-18 Monocyte count; LUSC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00389176 chr19:41859014 TGFB1 -0.41 -5.97 -0.31 6.11e-9 Electrocardiographic conduction measures; LUSC cis rs2404602 0.655 rs4886507 chr15:77209694 T/C cg23625390 chr15:77176239 SCAPER 0.47 6.96 0.36 1.8e-11 Blood metabolite levels; LUSC cis rs920590 0.642 rs6993525 chr8:19671104 A/G cg03894339 chr8:19674705 INTS10 -0.49 -6.97 -0.36 1.67e-11 Acute lymphoblastic leukemia (childhood); LUSC trans rs7824557 0.606 rs2736270 chr8:11192593 G/A cg15556689 chr8:8085844 FLJ10661 0.54 7.85 0.39 5.76e-14 Retinal vascular caliber; LUSC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg15649852 chr7:65879115 NA -0.41 -5.78 -0.3 1.74e-8 Aortic root size; LUSC cis rs61990749 0.597 rs176980 chr14:78198449 C/G cg02301378 chr14:78227641 SNW1;C14orf178 -0.57 -6.49 -0.33 3.03e-10 Fibroblast growth factor basic levels; LUSC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg06212747 chr3:49208901 KLHDC8B 0.44 6.03 0.31 4.44e-9 Parkinson's disease; LUSC cis rs7659604 0.502 rs13128434 chr4:122672461 A/C cg19748678 chr4:122722346 EXOSC9 -0.41 -6.07 -0.32 3.45e-9 Type 2 diabetes; LUSC cis rs68170813 0.559 rs10953530 chr7:106827796 A/C cg02696742 chr7:106810147 HBP1 -0.62 -9.51 -0.46 3.83e-19 Coronary artery disease; LUSC cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg03517284 chr6:25882590 NA -0.51 -9.63 -0.47 1.56e-19 Blood metabolite levels; LUSC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg00599273 chr12:58146742 CDK4 0.31 5.81 0.3 1.48e-8 Multiple sclerosis; LUSC cis rs6750047 0.625 rs59363818 chr2:38261973 A/C cg07380506 chr2:38303506 CYP1B1 -0.44 -6.09 -0.32 3.08e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs7524258 0.868 rs6693725 chr1:7307810 G/T cg07173049 chr1:7289937 CAMTA1 0.36 7.46 0.38 7.69e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg02018176 chr4:1364513 KIAA1530 0.48 8.15 0.41 7.43e-15 Longevity; LUSC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg22903471 chr2:27725779 GCKR -0.41 -6.83 -0.35 4.11e-11 Total body bone mineral density; LUSC cis rs17125944 0.615 rs17125798 chr14:53319905 G/A cg00686598 chr14:53173677 PSMC6 0.83 7.19 0.37 4.35e-12 Alzheimer's disease (late onset); LUSC cis rs4595586 0.545 rs1400284 chr12:39400419 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.99 0.31 5.41e-9 Morning vs. evening chronotype; LUSC cis rs6121246 0.697 rs6088857 chr20:30226764 G/C cg13852791 chr20:30311386 BCL2L1 0.84 10.27 0.49 1.12e-21 Mean corpuscular hemoglobin; LUSC trans rs236907 0.812 rs35249022 chr1:171760767 A/G cg13482142 chr2:234261155 NA 0.48 6.05 0.31 3.8e-9 Mean platelet volume; LUSC cis rs3818285 0.515 rs4918471 chr10:111660500 C/A cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.96 -0.44 2.29e-17 Superior crus of antihelix expression; LUSC cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg11266682 chr4:10021025 SLC2A9 0.59 10.66 0.5 4.78e-23 Bone mineral density; LUSC cis rs662064 1.000 rs662064 chr1:10557251 T/C cg20482658 chr1:10539492 PEX14 -0.31 -6.46 -0.33 3.75e-10 Asthma; LUSC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg04317338 chr11:64019027 PLCB3 0.56 6.64 0.34 1.29e-10 Mean platelet volume; LUSC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.36 -6.18 -0.32 1.88e-9 Breast cancer; LUSC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.76 -9.64 -0.47 1.47e-19 Gut microbiome composition (summer); LUSC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg12463550 chr7:65579703 CRCP 0.44 6.53 0.34 2.4e-10 Aortic root size; LUSC cis rs9790314 0.967 rs460165 chr3:161087710 G/A cg03342759 chr3:160939853 NMD3 -0.47 -7.72 -0.39 1.4e-13 Morning vs. evening chronotype; LUSC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg24101359 chr6:42928495 GNMT 0.37 6.07 0.32 3.5e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9911578 0.785 rs10853008 chr17:56993407 T/C cg12560992 chr17:57184187 TRIM37 -0.77 -11.86 -0.54 2.51e-27 Intelligence (multi-trait analysis); LUSC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg01416388 chr22:39784598 NA -0.45 -7.03 -0.36 1.15e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg03433033 chr1:76189801 ACADM 0.77 12.98 0.58 1.72e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1670533 1.000 rs935970 chr4:1045323 C/G cg02018176 chr4:1364513 KIAA1530 -0.46 -6.15 -0.32 2.22e-9 Recombination rate (females); LUSC cis rs11971779 0.680 rs6954547 chr7:139054734 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1712517 0.904 rs10883863 chr10:105161879 G/A cg05636881 chr10:105038444 INA -0.41 -6.86 -0.35 3.3e-11 Migraine; LUSC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -10.01 -0.48 8.25e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.52 0.65 2.71e-41 Bladder cancer; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg18402987 chr7:1209562 NA 0.68 7.4 0.38 1.09e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg04586622 chr2:25135609 ADCY3 0.43 8.99 0.44 1.89e-17 Body mass index; LUSC cis rs9467773 0.620 rs2451737 chr6:26619041 T/C cg05738196 chr6:26577821 NA 0.79 15.24 0.64 3.59e-40 Intelligence (multi-trait analysis); LUSC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg25838465 chr1:92012736 NA -0.66 -12.07 -0.55 4.57e-28 Breast cancer; LUSC cis rs4478858 0.735 rs6679365 chr1:31787866 A/C cg00250761 chr1:31883323 NA 0.33 8.33 0.41 2.18e-15 Alcohol dependence; LUSC trans rs7647973 0.626 rs4855882 chr3:49715354 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -6.93 -0.35 2.2e-11 Menarche (age at onset); LUSC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.54e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg24562669 chr7:97807699 LMTK2 -0.4 -6.56 -0.34 2.02e-10 Breast cancer; LUSC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg20135002 chr11:47629003 NA 0.49 7.79 0.39 8.39e-14 Subjective well-being; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20713102 chr15:85144157 ZSCAN2 0.45 6.31 0.33 8.8e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.46e-10 Body mass index; LUSC trans rs8085804 0.504 rs16976532 chr18:40240283 T/C cg04486886 chr5:56784195 NA -0.33 -6.48 -0.33 3.3e-10 Cognitive performance; LUSC cis rs78663649 0.908 rs113779505 chr19:16527982 G/A cg05286348 chr19:16641544 CHERP -0.61 -5.93 -0.31 7.38e-9 White blood cell count; LUSC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg06634786 chr22:41940651 POLR3H 0.49 5.76 0.3 1.88e-8 Vitiligo; LUSC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg15557168 chr22:42548783 NA -0.46 -7.35 -0.37 1.51e-12 Schizophrenia; LUSC cis rs4363385 0.782 rs1933381 chr1:153003255 C/G cg00922841 chr1:152955080 SPRR1A -0.43 -7.53 -0.38 4.82e-13 Inflammatory skin disease; LUSC trans rs561341 1.000 rs8069199 chr17:30281845 A/G cg27661571 chr11:113659931 NA -0.59 -7.18 -0.37 4.61e-12 Hip circumference adjusted for BMI; LUSC cis rs2455601 0.638 rs2568092 chr11:8987438 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.38 6.65 0.34 1.16e-10 Schizophrenia; LUSC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg09085632 chr11:111637200 PPP2R1B -1.05 -17.32 -0.69 2.06e-48 Primary sclerosing cholangitis; LUSC cis rs12594515 0.967 rs11856523 chr15:45989495 C/T cg19682013 chr15:45996608 NA 0.38 5.8 0.3 1.53e-8 Waist circumference;Weight; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.26 0.45 2.6e-18 Prudent dietary pattern; LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.02 0.36 1.28e-11 Gut microbiome composition (summer); LUSC cis rs3126085 1.000 rs4845756 chr1:152254919 T/A cg26876637 chr1:152193138 HRNR 0.46 6.38 0.33 6.03e-10 Atopic dermatitis; LUSC cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg05283184 chr6:79620031 NA -0.45 -8.45 -0.42 9.37e-16 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg07092213 chr7:1199455 ZFAND2A -0.56 -8.44 -0.42 9.86e-16 Longevity;Endometriosis; LUSC trans rs7939886 0.920 rs11534518 chr11:55808146 C/T cg15704280 chr7:45808275 SEPT13 0.8 6.88 0.35 3.04e-11 Myopia (pathological); LUSC cis rs61935443 0.614 rs11107792 chr12:95317126 G/C cg21533806 chr12:95267307 NA 0.49 5.69 0.3 2.72e-8 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07156296 chr4:108911347 HADH 0.36 6.03 0.31 4.24e-9 Triglycerides; LUSC cis rs6496667 0.533 rs7172909 chr15:90991416 C/T cg10434728 chr15:90938212 IQGAP1 0.33 6.2 0.32 1.63e-9 Rheumatoid arthritis; LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.62e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg06238570 chr21:40685208 BRWD1 -0.6 -10.14 -0.49 3e-21 Cognitive function; LUSC cis rs1443512 0.947 rs4759309 chr12:54342786 G/A cg17410650 chr12:54324560 NA -0.43 -6.95 -0.36 1.87e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg14298792 chr15:30685198 CHRFAM7A 0.46 5.87 0.31 1.07e-8 Huntington's disease progression; LUSC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg18904891 chr8:8559673 CLDN23 0.61 8.47 0.42 7.74e-16 Obesity-related traits; LUSC cis rs6681460 0.934 rs4655631 chr1:67054907 C/G cg02459107 chr1:67143332 SGIP1 0.48 8.96 0.44 2.32e-17 Presence of antiphospholipid antibodies; LUSC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg00999904 chr2:3704751 ALLC -0.44 -6.76 -0.35 6.12e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg27170947 chr2:26402098 FAM59B 0.66 9.86 0.47 2.78e-20 Gut microbiome composition (summer); LUSC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg14552801 chr7:65878734 NA 0.46 6.65 0.34 1.22e-10 Aortic root size; LUSC cis rs4776059 0.798 rs13329393 chr15:52920505 A/T cg24008177 chr15:52972085 KIAA1370 -0.34 -6.26 -0.32 1.2e-9 Schizophrenia; LUSC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.91 -0.35 2.48e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2667011 0.756 rs2715920 chr2:160837815 T/C cg06573604 chr2:160760825 LY75 -0.49 -6.31 -0.33 8.87e-10 Bilirubin levels; LUSC cis rs6426558 0.537 rs4351610 chr1:227325245 A/G cg10327440 chr1:227177885 CDC42BPA -0.55 -7.4 -0.38 1.11e-12 Neutrophil percentage of white cells; LUSC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg24250549 chr1:154909240 PMVK 0.65 10.87 0.51 9.05e-24 Prostate cancer; LUSC cis rs748404 0.697 rs564946 chr15:43556272 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.35 0.42 1.83e-15 Lung cancer; LUSC trans rs61931739 1.000 rs61931739 chr12:34089973 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.81 -0.39 7.71e-14 Morning vs. evening chronotype; LUSC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7584330 0.518 rs74478860 chr2:238437364 C/G cg16989719 chr2:238392110 NA -0.49 -6.21 -0.32 1.58e-9 Prostate cancer; LUSC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg25282410 chr6:160211355 TCP1;MRPL18 1.08 16.47 0.67 4.75e-45 Age-related macular degeneration (geographic atrophy); LUSC cis rs9650657 0.504 rs2409724 chr8:11041642 A/T cg21775007 chr8:11205619 TDH -0.52 -7.45 -0.38 7.96e-13 Neuroticism; LUSC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg08048268 chr3:133502702 NA -0.44 -8.51 -0.42 6.17e-16 Iron status biomarkers; LUSC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.74e-12 Resting heart rate; LUSC cis rs694739 0.687 rs11231771 chr11:64140642 T/G cg02228329 chr11:64053129 BAD;GPR137 0.44 6.26 0.32 1.17e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs4780401 0.728 rs6498239 chr16:11780774 T/C cg01061890 chr16:11836724 TXNDC11 -0.43 -6.08 -0.32 3.27e-9 Rheumatoid arthritis; LUSC trans rs2392780 0.536 rs444318 chr8:128333513 A/G cg10195415 chr17:73887371 TRIM65 0.4 6.49 0.33 3.15e-10 Breast cancer (early onset); LUSC cis rs68170813 0.523 rs12532447 chr7:106940476 C/T cg02696742 chr7:106810147 HBP1 -0.62 -9.45 -0.46 5.95e-19 Coronary artery disease; LUSC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg20476274 chr7:133979776 SLC35B4 0.86 16.61 0.67 1.4e-45 Mean platelet volume; LUSC cis rs9644630 0.932 rs4921653 chr8:19359853 C/T cg01280390 chr8:19363452 CSGALNACT1 0.37 7.04 0.36 1.1e-11 Oropharynx cancer; LUSC cis rs7247513 0.930 rs35275129 chr19:12716493 G/A cg01871581 chr19:12707946 ZNF490 -0.6 -9.62 -0.47 1.73e-19 Bipolar disorder; LUSC cis rs1008375 0.966 rs6449325 chr4:17699509 C/T cg16339924 chr4:17578868 LAP3 -0.46 -6.77 -0.35 5.92e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2840044 1.000 rs10068 chr17:33901965 C/G cg05299278 chr17:33885742 SLFN14 -0.31 -6.4 -0.33 5.36e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg20406979 chr6:167373233 NA -0.26 -6.18 -0.32 1.83e-9 Crohn's disease; LUSC cis rs950027 0.620 rs1145080 chr15:45681338 C/T cg14582100 chr15:45693742 SPATA5L1 0.46 8.67 0.43 1.87e-16 Response to fenofibrate (adiponectin levels); LUSC cis rs7523273 0.606 rs10449303 chr1:207961058 A/G cg22525895 chr1:207977042 MIR29B2 -0.4 -6.31 -0.33 8.89e-10 Schizophrenia; LUSC cis rs2290416 0.681 rs3793371 chr8:144664299 C/T cg08017634 chr8:144659831 NAPRT1 0.69 6.16 0.32 2.1e-9 Attention deficit hyperactivity disorder; LUSC cis rs1904096 0.506 rs8336 chr4:95211610 A/G cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.67 -0.43 1.84e-16 Type 2 diabetes; LUSC cis rs7592578 0.679 rs62181020 chr2:191325601 A/C cg11845111 chr2:191398756 TMEM194B -0.84 -11.15 -0.52 9.03e-25 Diastolic blood pressure; LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC trans rs2414059 0.518 rs56398519 chr15:50773432 A/G cg06848185 chr17:75368902 SEPT9 0.37 6.05 0.31 3.87e-9 QT interval; LUSC cis rs4728302 0.608 rs10254118 chr7:133158353 T/A cg10665199 chr7:133106180 EXOC4 0.58 8.16 0.41 6.67e-15 Intelligence;Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg13206674 chr6:150067644 NUP43 0.61 9.71 0.47 8.23e-20 Lung cancer; LUSC cis rs9916302 0.706 rs9908131 chr17:37520449 T/C cg07936489 chr17:37558343 FBXL20 0.8 9.85 0.47 2.9e-20 Glomerular filtration rate (creatinine); LUSC cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg21132104 chr15:45694354 SPATA5L1 0.49 6.5 0.34 2.92e-10 Homoarginine levels; LUSC cis rs7089973 0.872 rs41284358 chr10:116622339 A/G cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 6.16e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1559088 0.947 rs12461297 chr19:33559245 A/G cg03563238 chr19:33554763 RHPN2 -0.4 -6.23 -0.32 1.43e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.72 -0.35 7.86e-11 Developmental language disorder (linguistic errors); LUSC cis rs4588572 0.644 rs11742212 chr5:77779033 G/A cg11547950 chr5:77652471 NA -0.44 -6.23 -0.32 1.4e-9 Triglycerides; LUSC cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg05283184 chr6:79620031 NA -0.57 -11.68 -0.54 1.16e-26 Intelligence (multi-trait analysis); LUSC cis rs7216064 1.000 rs3935969 chr17:65881959 A/G cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2458413 0.521 rs2458427 chr8:105339594 G/T cg04554929 chr8:105342491 NA -0.4 -7.28 -0.37 2.35e-12 Paget's disease; LUSC cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg19789473 chr17:27170043 C17orf63 -0.3 -5.69 -0.3 2.75e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1949733 0.636 rs16842498 chr4:8539529 C/T cg11789530 chr4:8429930 ACOX3 -0.42 -6.1 -0.32 2.95e-9 Response to antineoplastic agents; LUSC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg26597838 chr10:835615 NA 0.99 13.86 0.6 8.07e-35 Eosinophil percentage of granulocytes; LUSC cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs1018836 0.632 rs9642910 chr8:91475724 G/T cg16814680 chr8:91681699 NA -0.65 -9.66 -0.47 1.3e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs34421088 0.560 rs2248316 chr8:11397073 A/C cg08975724 chr8:8085496 FLJ10661 -0.51 -7.59 -0.38 3.13e-13 Neuroticism; LUSC cis rs9487051 0.738 rs449850 chr6:109525045 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -5.74 -0.3 2.09e-8 Reticulocyte fraction of red cells; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg16325326 chr1:53192061 ZYG11B 0.86 15.02 0.63 2.62e-39 Monocyte count; LUSC cis rs6596100 0.538 rs67652061 chr5:132280347 T/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Breast cancer; LUSC cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -7.96 -0.4 2.77e-14 Bone mineral density; LUSC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2281845 0.929 rs7549337 chr1:201097609 T/G cg22815214 chr1:201083145 CACNA1S 0.57 9.36 0.46 1.18e-18 Permanent tooth development; LUSC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs17286411 0.787 rs1834036 chr16:71972060 G/A cg03805757 chr16:71968109 PKD1L3 0.42 6.94 0.36 2.03e-11 Blood protein levels; LUSC cis rs27434 0.583 rs193482 chr5:96157846 A/G cg16492584 chr5:96139282 ERAP1 -0.56 -7.53 -0.38 4.91e-13 Ankylosing spondylitis; LUSC cis rs17407555 0.738 rs56402960 chr4:10086473 T/A cg00071950 chr4:10020882 SLC2A9 -0.52 -6.28 -0.33 1.03e-9 Schizophrenia (age at onset); LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg00149659 chr3:10157352 C3orf10 1.0 14.13 0.61 7.39e-36 Alzheimer's disease; LUSC cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.66e-8 Morning vs. evening chronotype; LUSC cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.38 0.49 4.76e-22 Schizophrenia; LUSC cis rs6692729 0.966 rs7547071 chr1:227014390 A/G cg10327440 chr1:227177885 CDC42BPA -0.48 -6.89 -0.35 2.82e-11 Electrodermal activity; LUSC cis rs9549260 0.755 rs9549236 chr13:41147158 C/T cg21288729 chr13:41239152 FOXO1 -0.53 -7.86 -0.4 5.27e-14 Red blood cell count; LUSC cis rs1971762 0.563 rs4759284 chr12:54079491 G/A cg23533419 chr12:54090519 NA -0.37 -6.01 -0.31 4.79e-9 Height; LUSC cis rs1008375 0.900 rs6812675 chr4:17597549 A/G cg16339924 chr4:17578868 LAP3 0.65 9.84 0.47 3.21e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg22535103 chr8:58192502 C8orf71 -0.75 -9.42 -0.46 7.57e-19 Developmental language disorder (linguistic errors); LUSC trans rs1470506 0.507 rs62171962 chr2:77224930 C/T cg01707656 chr12:12503030 MANSC1 0.45 5.94 0.31 7.05e-9 IgG glycosylation; LUSC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -9.92 -0.48 1.68e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs1395 0.778 rs72810794 chr2:27401260 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.49 7.26 0.37 2.77e-12 Blood metabolite levels; LUSC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg21918786 chr6:109611834 NA -0.42 -7.28 -0.37 2.36e-12 Reticulocyte fraction of red cells; LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg21548813 chr6:291882 DUSP22 -0.51 -7.67 -0.39 1.87e-13 Menopause (age at onset); LUSC trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg03929089 chr4:120376271 NA 0.82 11.14 0.52 9.93e-25 Coronary artery disease; LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg25072359 chr17:41440525 NA 0.68 9.69 0.47 9.97e-20 Menopause (age at onset); LUSC cis rs7223966 1.000 rs11658740 chr17:61751069 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.83 0.35 4.1e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2692947 0.832 rs2579519 chr2:96675166 T/C cg23100626 chr2:96804247 ASTL 0.26 6.61 0.34 1.54e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg04586622 chr2:25135609 ADCY3 0.43 9.0 0.44 1.7e-17 Body mass index; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.96 0.77 8.44e-67 Prudent dietary pattern; LUSC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg03233332 chr7:66118400 NA -0.4 -5.92 -0.31 8.15e-9 Aortic root size; LUSC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg01657329 chr11:68192670 LRP5 -0.44 -6.59 -0.34 1.73e-10 Total body bone mineral density; LUSC trans rs9467711 0.720 rs35627490 chr6:26462104 C/T cg06606381 chr12:133084897 FBRSL1 -0.7 -6.25 -0.32 1.26e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs7824557 0.564 rs2043508 chr8:11227406 G/A cg08975724 chr8:8085496 FLJ10661 -0.51 -7.43 -0.38 9.08e-13 Retinal vascular caliber; LUSC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg07395648 chr5:131743802 NA 0.38 6.01 0.31 4.87e-9 Asthma (sex interaction); LUSC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.54 -0.42 4.74e-16 Personality dimensions; LUSC cis rs4595586 0.525 rs11609150 chr12:39408622 A/C cg13010199 chr12:38710504 ALG10B 0.45 6.38 0.33 5.87e-10 Morning vs. evening chronotype; LUSC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg16049864 chr8:95962084 TP53INP1 -0.62 -11.56 -0.53 3.2e-26 Type 2 diabetes; LUSC cis rs10979 0.965 rs9390109 chr6:143892806 T/C cg25407410 chr6:143891975 LOC285740 -0.73 -11.95 -0.55 1.25e-27 Hypospadias; LUSC cis rs9837602 0.935 rs9810235 chr3:99736538 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.09 -0.32 3.14e-9 Breast cancer; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 15.59 0.65 1.47e-41 Platelet count; LUSC cis rs8078723 0.738 rs8066582 chr17:38146929 A/G cg17467752 chr17:38218738 THRA -0.69 -11.22 -0.52 5.09e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg16797656 chr11:68205561 LRP5 0.49 9.01 0.44 1.67e-17 Total body bone mineral density; LUSC cis rs7107174 0.901 rs10899496 chr11:78123831 A/G cg02023728 chr11:77925099 USP35 0.4 6.16 0.32 2.14e-9 Testicular germ cell tumor; LUSC trans rs1448094 0.791 rs7300340 chr12:86329867 G/T cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs12900413 0.603 rs2882677 chr15:90299514 C/T cg24249390 chr15:90295951 MESP1 -0.35 -5.77 -0.3 1.83e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs11122272 0.668 rs2790874 chr1:231537988 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.31 -0.49 7.92e-22 Hemoglobin concentration; LUSC cis rs7100689 0.598 rs35353819 chr10:82135737 A/G cg00277334 chr10:82204260 NA -0.51 -7.43 -0.38 9.29e-13 Post bronchodilator FEV1; LUSC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg11752832 chr7:134001865 SLC35B4 0.56 8.81 0.43 6.79e-17 Mean platelet volume; LUSC cis rs7178572 0.568 rs11072643 chr15:77415508 T/A cg22256960 chr15:77711686 NA 0.49 7.57 0.38 3.75e-13 Type 2 diabetes; LUSC cis rs478304 0.934 rs12801731 chr11:65549606 T/C cg08755490 chr11:65554678 OVOL1 0.42 6.02 0.31 4.69e-9 Acne (severe); LUSC trans rs34421088 0.532 rs2736385 chr8:11148613 T/C cg06636001 chr8:8085503 FLJ10661 0.49 7.17 0.37 4.8e-12 Neuroticism; LUSC cis rs603446 0.967 rs108533 chr11:116601711 A/T cg08985259 chr11:116699649 APOC3 0.24 5.69 0.3 2.72e-8 Triglycerides; LUSC cis rs9837602 1.000 rs6790877 chr3:99779658 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.86 -0.31 1.09e-8 Breast cancer; LUSC cis rs34375054 0.624 rs7132026 chr12:125678096 A/G cg06287003 chr12:125626642 AACS 0.38 5.92 0.31 7.84e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg18876405 chr7:65276391 NA -0.69 -12.42 -0.56 2.15e-29 Aortic root size; LUSC cis rs734999 0.545 rs4648356 chr1:2709164 C/A cg18932078 chr1:2524107 MMEL1 0.3 6.49 0.33 3.19e-10 Ulcerative colitis; LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.73 0.35 7.61e-11 Obesity-related traits; LUSC cis rs11676348 0.712 rs12694426 chr2:218942351 T/G cg00012203 chr2:219082015 ARPC2 -0.46 -7.02 -0.36 1.22e-11 Ulcerative colitis; LUSC cis rs13315871 0.858 rs78946071 chr3:58318523 G/T cg20936604 chr3:58311152 NA -0.77 -7.1 -0.36 7.59e-12 Cholesterol, total; LUSC cis rs738322 0.967 rs133013 chr22:38570912 C/T cg17652424 chr22:38574118 PLA2G6 -0.29 -6.41 -0.33 5e-10 Cutaneous nevi; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05989775 chr11:2906934 CDKN1C -0.48 -6.39 -0.33 5.65e-10 Bipolar disorder and schizophrenia; LUSC cis rs1403694 0.515 rs1648699 chr3:186449890 G/C cg12454167 chr3:186435060 KNG1 0.28 7.6 0.38 2.98e-13 Blood protein levels; LUSC cis rs17270561 0.583 rs7765833 chr6:25712433 C/A cg16482183 chr6:26056742 HIST1H1C 0.6 8.77 0.43 9.05e-17 Iron status biomarkers; LUSC cis rs1577917 0.958 rs2121594 chr6:86576854 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.94 -0.44 2.67e-17 Response to antipsychotic treatment; LUSC cis rs2204008 0.521 rs7311188 chr12:38542813 C/G cg13010199 chr12:38710504 ALG10B -0.43 -6.43 -0.33 4.49e-10 Bladder cancer; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg18357908 chr19:41107082 LTBP4 0.36 6.05 0.31 3.86e-9 Metabolite levels (Pyroglutamine); LUSC cis rs1997103 1.000 rs6950311 chr7:55400990 G/A cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07283595 chr17:5372003 DHX33 0.44 6.71 0.34 8.15e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs970548 0.697 rs11239534 chr10:45968590 A/T cg14222797 chr10:16859974 RSU1 0.6 5.97 0.31 6.16e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.27 -0.41 3.24e-15 Cystic fibrosis severity; LUSC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.14 -0.8 3.2e-75 Height; LUSC trans rs11098499 0.866 rs12499602 chr4:120284387 T/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg04450456 chr4:17643702 FAM184B 0.41 6.96 0.36 1.77e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg15790184 chr11:494944 RNH1 0.53 5.77 0.3 1.85e-8 Body mass index; LUSC cis rs12760731 0.720 rs10913545 chr1:178360201 G/A cg00404053 chr1:178313656 RASAL2 0.6 6.32 0.33 8.53e-10 Obesity-related traits; LUSC cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg03146154 chr1:46216737 IPP 0.52 7.67 0.39 1.9e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs9650657 0.645 rs4841409 chr8:10516374 C/T cg06636001 chr8:8085503 FLJ10661 0.48 6.97 0.36 1.69e-11 Neuroticism; LUSC cis rs909002 0.849 rs6425777 chr1:32105447 G/C cg01639898 chr1:32083012 HCRTR1 0.25 5.74 0.3 2.08e-8 Intelligence (multi-trait analysis); LUSC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg04166393 chr7:2884313 GNA12 0.44 5.69 0.3 2.71e-8 Height; LUSC cis rs11250098 0.574 rs4240672 chr8:10767917 G/A cg27411982 chr8:10470053 RP1L1 -0.46 -6.8 -0.35 4.87e-11 Morning vs. evening chronotype; LUSC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18402987 chr7:1209562 NA 0.38 5.85 0.3 1.16e-8 Longevity;Endometriosis; LUSC cis rs829883 0.659 rs11109517 chr12:98921574 A/C cg25150519 chr12:98850993 NA 0.63 8.59 0.43 3.43e-16 Colorectal adenoma (advanced); LUSC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.79 0.39 8.37e-14 Parkinson's disease; LUSC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02018176 chr4:1364513 KIAA1530 0.72 13.64 0.6 5.72e-34 Longevity; LUSC trans rs10838801 1 rs10838801 chr11:48098280 G/A cg03929089 chr4:120376271 NA -0.58 -7.53 -0.38 4.82e-13 Height; LUSC cis rs3782089 1.000 rs11600543 chr11:65298939 G/A cg11802864 chr11:65308245 LTBP3 0.84 5.81 0.3 1.45e-8 Height; LUSC cis rs921665 0.831 rs2242084 chr2:3196040 A/G cg16434511 chr2:3151078 NA -0.63 -6.83 -0.35 3.92e-11 World class endurance athleticism; LUSC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg08704250 chr15:31115839 NA -0.59 -9.2 -0.45 3.95e-18 Huntington's disease progression; LUSC cis rs2273669 0.667 rs111523655 chr6:109301664 G/A cg05315195 chr6:109294784 ARMC2 -0.55 -6.18 -0.32 1.86e-9 Prostate cancer; LUSC cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg16145915 chr7:1198662 ZFAND2A -0.47 -8.44 -0.42 9.48e-16 Longevity;Endometriosis; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10189605 chr6:58287430 GUSBL2 -0.36 -6.13 -0.32 2.49e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2969070 0.639 rs886629 chr7:2528060 A/C cg03277898 chr7:2518824 NA -0.29 -6.19 -0.32 1.8e-9 Diastolic blood pressure; LUSC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg14552801 chr7:65878734 NA -0.38 -5.86 -0.31 1.13e-8 Aortic root size; LUSC trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg15704280 chr7:45808275 SEPT13 -0.5 -7.09 -0.36 7.83e-12 HDL cholesterol; LUSC cis rs5771069 0.897 rs137858 chr22:50445601 T/C cg03721641 chr22:50451245 IL17REL 0.28 5.88 0.31 9.87e-9 Ulcerative colitis; LUSC cis rs7639513 0.767 rs9861472 chr3:12707776 A/T cg23032965 chr3:12705835 RAF1 -0.75 -11.79 -0.54 4.82e-27 Itch intensity from mosquito bite; LUSC cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg13010199 chr12:38710504 ALG10B 0.53 8.16 0.41 6.69e-15 Morning vs. evening chronotype; LUSC cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg01657329 chr11:68192670 LRP5 -0.44 -6.6 -0.34 1.64e-10 Total body bone mineral density; LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg08470875 chr2:26401718 FAM59B 0.65 8.56 0.42 4.16e-16 Gut microbiome composition (summer); LUSC cis rs2486288 0.656 rs11854325 chr15:45548959 T/C cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.91 -0.4 3.89e-14 Glomerular filtration rate; LUSC cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.85 0.39 5.56e-14 Colorectal cancer; LUSC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg08645402 chr16:4508243 NA 0.48 7.66 0.39 2.06e-13 Schizophrenia; LUSC cis rs13202913 0.733 rs13215869 chr6:151803659 G/A cg03627880 chr6:151815985 C6orf97 -0.57 -6.12 -0.32 2.63e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs6076065 0.630 rs2424558 chr20:23429344 A/G cg11657817 chr20:23433608 CST11 0.52 10.91 0.51 6.34e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg23992470 chr4:843637 GAK 0.6 6.41 0.33 5.02e-10 Intelligence (multi-trait analysis); LUSC cis rs3857536 0.813 rs2040594 chr6:66943966 A/G cg07460842 chr6:66804631 NA -0.46 -6.41 -0.33 4.93e-10 Blood trace element (Cu levels); LUSC cis rs11190604 1.000 rs9420797 chr10:102331147 C/T cg07080220 chr10:102295463 HIF1AN 0.64 9.31 0.45 1.73e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1371867 0.846 rs1660347 chr8:101314980 G/A cg00191853 chr8:101177733 SPAG1 -0.41 -6.57 -0.34 1.92e-10 Atrioventricular conduction; LUSC cis rs7107174 0.786 rs4945262 chr11:77990831 T/C cg02023728 chr11:77925099 USP35 0.47 6.53 0.34 2.39e-10 Testicular germ cell tumor; LUSC cis rs72781680 1.000 rs72781653 chr2:24215633 T/C cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.3e-21 Lymphocyte counts; LUSC cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg13010199 chr12:38710504 ALG10B 0.66 10.22 0.49 1.61e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs9323205 0.765 rs2999390 chr14:51654944 C/G cg23942311 chr14:51606299 NA -0.31 -6.44 -0.33 4.12e-10 Cancer; LUSC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg00684032 chr4:1343700 KIAA1530 0.37 6.51 0.34 2.82e-10 Obesity-related traits; LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg00149659 chr3:10157352 C3orf10 0.99 14.48 0.62 3.24e-37 Alzheimer's disease; LUSC cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.48 7.19 0.37 4.32e-12 Schizophrenia; LUSC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg27189623 chr16:705930 WDR90 0.35 5.68 0.3 2.86e-8 Height; LUSC cis rs981844 0.775 rs62324020 chr4:154763851 G/A cg14289246 chr4:154710475 SFRP2 0.5 6.67 0.34 1.09e-10 Response to statins (LDL cholesterol change); LUSC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg10556349 chr10:835070 NA 0.58 6.49 0.33 3.12e-10 Eosinophil percentage of granulocytes; LUSC cis rs13385 0.724 rs60714373 chr5:139651321 T/C cg26211634 chr5:139558579 C5orf32 0.44 6.21 0.32 1.53e-9 Atrial fibrillation; LUSC cis rs10751667 0.643 rs11246344 chr11:933783 A/C ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs3741151 0.773 rs11820577 chr11:73261424 C/G cg17517138 chr11:73019481 ARHGEF17 0.92 7.8 0.39 8.22e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg06454157 chr6:167490870 NA -0.25 -6.02 -0.31 4.66e-9 Crohn's disease; LUSC cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg13256891 chr4:100009986 ADH5 0.52 8.48 0.42 7.24e-16 Alcohol dependence; LUSC cis rs924607 0.583 rs12516251 chr5:608939 C/T cg07001201 chr5:642380 CEP72 0.35 5.78 0.3 1.67e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg23711669 chr6:146136114 FBXO30 0.84 15.31 0.64 1.92e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs73198271 0.562 rs55961293 chr8:8675478 T/C cg01851573 chr8:8652454 MFHAS1 0.65 8.45 0.42 8.99e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs9944715 0.906 rs8095729 chr18:43741982 T/C cg01718231 chr17:29326311 RNF135 0.45 6.31 0.33 9.11e-10 Red cell distribution width;Mean corpuscular volume; LUSC cis rs644799 0.710 rs10831427 chr11:95508383 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.12 0.58 5.41e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg14594481 chr12:6863015 MLF2 -0.4 -6.12 -0.32 2.62e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg09469691 chr10:81107165 PPIF 0.68 10.56 0.5 1.1e-22 Height; LUSC cis rs7572644 0.699 rs4390729 chr2:28162861 T/C cg27432699 chr2:27873401 GPN1 -0.51 -6.83 -0.35 4.08e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg03354898 chr7:1950403 MAD1L1 -0.33 -6.43 -0.33 4.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs17854409 0.536 rs3765464 chr20:61485236 T/C cg05147244 chr20:61493195 TCFL5 0.94 7.43 0.38 9.04e-13 Obesity-related traits; LUSC trans rs1728785 1.000 rs3203684 chr16:68600440 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.63 -8.29 -0.41 2.72e-15 Ulcerative colitis; LUSC cis rs7903847 0.642 rs11189192 chr10:99149403 G/A cg08345082 chr10:99160200 RRP12 -0.35 -7.02 -0.36 1.25e-11 Granulocyte percentage of myeloid white cells; LUSC cis rs10751667 0.600 rs1128413 chr11:1010694 C/T ch.11.42038R chr11:967971 AP2A2 0.42 6.15 0.32 2.2e-9 Alzheimer's disease (late onset); LUSC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.32 0.33 8.28e-10 Bipolar disorder; LUSC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg26408565 chr15:76604113 ETFA -0.51 -8.14 -0.41 7.82e-15 Blood metabolite levels; LUSC cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg16240275 chr20:61666158 NCRNA00029 0.42 9.23 0.45 3.14e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs754466 0.651 rs10762767 chr10:79645070 C/A cg17075019 chr10:79541650 NA -0.76 -12.11 -0.55 3.16e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs710865 0.519 rs3748759 chr1:19487656 C/T cg13387374 chr1:19411106 UBR4 -0.53 -8.31 -0.41 2.39e-15 Brain structure; LUSC cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg13010199 chr12:38710504 ALG10B 0.62 9.65 0.47 1.3e-19 Bladder cancer; LUSC cis rs1878931 0.858 rs3760083 chr16:3450052 C/T cg00484396 chr16:3507460 NAT15 0.38 6.01 0.31 4.8e-9 Body mass index (adult); LUSC cis rs738322 0.753 rs5756968 chr22:38595240 C/T cg25457927 chr22:38595422 NA 0.52 11.56 0.53 3.14e-26 Cutaneous nevi; LUSC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg21573476 chr21:45109991 RRP1B -0.36 -5.7 -0.3 2.66e-8 Mean corpuscular volume; LUSC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.6 0.38 3.08e-13 Bipolar disorder; LUSC cis rs72634258 0.554 rs12741937 chr1:7897622 A/T cg26816564 chr1:7831052 VAMP3 0.96 13.23 0.59 1.99e-32 Inflammatory bowel disease; LUSC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg13393036 chr8:95962371 TP53INP1 -0.32 -6.21 -0.32 1.59e-9 Type 2 diabetes; LUSC cis rs9920506 0.536 rs11636605 chr15:78928878 A/G cg04896959 chr15:78267971 NA 0.38 6.7 0.34 8.66e-11 Post bronchodilator FEV1; LUSC cis rs3916 0.911 rs7313271 chr12:121152667 C/T cg27246729 chr12:121163418 ACADS 0.5 7.25 0.37 2.99e-12 Urinary metabolites (H-NMR features); LUSC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg06634786 chr22:41940651 POLR3H 0.53 6.16 0.32 2.08e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg23719950 chr11:63933701 MACROD1 -0.37 -5.67 -0.3 3.03e-8 Platelet count; LUSC cis rs734999 0.545 rs12752515 chr1:2564465 T/C cg18854424 chr1:2615690 NA -0.49 -9.94 -0.48 1.48e-20 Ulcerative colitis; LUSC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg11301795 chr4:187892539 NA -0.8 -15.6 -0.65 1.37e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs4363385 0.668 rs6587717 chr1:152984443 G/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.61 -0.38 2.89e-13 Inflammatory skin disease; LUSC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -6.9 -0.35 2.59e-11 Alzheimer's disease (late onset); LUSC cis rs7582180 0.627 rs2241811 chr2:101011724 C/T cg12002119 chr2:101014098 CHST10 0.37 6.19 0.32 1.78e-9 Intelligence (multi-trait analysis); LUSC cis rs7605827 0.866 rs9710962 chr2:15533884 C/A cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs12467847 1.000 rs4387792 chr2:113691288 T/C cg12858261 chr2:113808755 IL1F8 -0.38 -5.72 -0.3 2.32e-8 Response to amphetamines; LUSC cis rs34779708 0.966 rs10827491 chr10:35427395 G/A cg03585969 chr10:35415529 CREM 0.6 8.97 0.44 2.11e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7903847 0.642 rs12258560 chr10:99137048 T/C cg20016023 chr10:99160130 RRP12 -0.34 -8.41 -0.42 1.22e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg14416726 chr6:151773293 C6orf211;RMND1 0.67 10.74 0.51 2.52e-23 Menarche (age at onset); LUSC cis rs4808199 0.947 rs1465695 chr19:19588546 A/C cg03709012 chr19:19516395 GATAD2A 1.08 14.22 0.61 3.19e-36 Nonalcoholic fatty liver disease; LUSC cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg03517284 chr6:25882590 NA -0.51 -9.52 -0.46 3.59e-19 Blood metabolite levels; LUSC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg08677398 chr8:58056175 NA 0.45 6.43 0.33 4.38e-10 Developmental language disorder (linguistic errors); LUSC trans rs12579753 0.917 rs10862361 chr12:82197946 T/C cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg06212747 chr3:49208901 KLHDC8B 0.43 5.82 0.3 1.39e-8 Parkinson's disease; LUSC cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg06028605 chr16:24865363 SLC5A11 0.49 8.57 0.42 3.76e-16 Intelligence (multi-trait analysis); LUSC cis rs9987353 0.566 rs6998368 chr8:9070288 G/C cg15556689 chr8:8085844 FLJ10661 -0.47 -6.56 -0.34 2e-10 Recombination measurement; LUSC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg23093090 chr10:104574429 C10orf26 0.43 7.72 0.39 1.37e-13 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs1800469 1.000 rs1549933 chr19:41871142 A/G cg08477640 chr19:41863820 B9D2 0.53 7.68 0.39 1.75e-13 Colorectal cancer; LUSC cis rs55871839 0.708 rs4738731 chr8:59809840 C/G cg07426533 chr8:59803705 TOX -0.36 -5.92 -0.31 7.88e-9 Pneumonia; LUSC cis rs6733011 0.578 rs4851170 chr2:99504323 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.41 5.83 0.3 1.31e-8 Bipolar disorder; LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg18404041 chr3:52824283 ITIH1 -0.6 -11.57 -0.53 3.03e-26 Bipolar disorder; LUSC cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg25174290 chr11:3078921 CARS 0.59 9.57 0.46 2.48e-19 Longevity; LUSC cis rs137603 0.562 rs470080 chr22:39712368 C/T cg17798944 chr22:39715225 SNORD43;RPL3 -0.45 -6.99 -0.36 1.51e-11 Primary biliary cholangitis; LUSC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg13206674 chr6:150067644 NUP43 0.58 8.91 0.44 3.38e-17 Lung cancer; LUSC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.33 -0.33 7.78e-10 Developmental language disorder (linguistic errors); LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg07167872 chr1:205819463 PM20D1 0.88 17.27 0.69 3.45e-48 Menarche (age at onset); LUSC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.9 -0.35 2.64e-11 Tonsillectomy; LUSC trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg15704280 chr7:45808275 SEPT13 0.73 8.22 0.41 4.64e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg13319975 chr6:146136371 FBXO30 0.5 7.46 0.38 7.55e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9902453 0.967 rs1042173 chr17:28525011 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.97 0.44 2.21e-17 Coffee consumption (cups per day); LUSC cis rs6752107 1.000 rs13391356 chr2:234170369 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.58 0.54 2.64e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg06212747 chr3:49208901 KLHDC8B 0.5 6.38 0.33 5.87e-10 Parkinson's disease; LUSC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg02772935 chr3:125709198 NA -0.47 -5.71 -0.3 2.45e-8 Blood pressure (smoking interaction); LUSC cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg09184832 chr6:79620586 NA -0.37 -5.83 -0.3 1.34e-8 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg08280861 chr8:58055591 NA 0.52 6.83 0.35 3.92e-11 Developmental language disorder (linguistic errors); LUSC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg15445000 chr17:37608096 MED1 -0.42 -7.05 -0.36 1.02e-11 Glomerular filtration rate (creatinine); LUSC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11644478 chr21:40555479 PSMG1 -0.59 -9.3 -0.45 1.88e-18 Menarche (age at onset); LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg18765753 chr7:1198926 ZFAND2A -0.35 -6.14 -0.32 2.38e-9 Longevity;Endometriosis; LUSC cis rs1670533 0.615 rs59985183 chr4:1087171 G/T cg27284194 chr4:1044797 NA 0.59 8.91 0.44 3.33e-17 Recombination rate (females); LUSC cis rs6940638 0.513 rs4424065 chr6:27036456 C/T cg09904177 chr6:26538194 HMGN4 -0.49 -7.68 -0.39 1.8e-13 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11890956 chr21:40555474 PSMG1 0.9 16.11 0.66 1.35e-43 Cognitive function; LUSC cis rs68170813 0.559 rs7794965 chr7:106826439 A/G cg24556660 chr7:106842632 COG5;HBP1 0.42 5.89 0.31 9.67e-9 Coronary artery disease; LUSC cis rs1160297 0.609 rs6715847 chr2:53097378 T/G cg07782112 chr2:53107842 NA 0.4 6.58 0.34 1.84e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs10197940 0.545 rs2444267 chr2:152308611 T/G cg06191203 chr2:152266755 RIF1 -0.42 -5.84 -0.3 1.27e-8 Lung cancer; LUSC cis rs6942756 1.000 rs11763056 chr7:128960871 C/A cg02491457 chr7:128862824 NA -0.47 -6.31 -0.33 9.1e-10 White matter hyperintensity burden; LUSC cis rs9517320 1.000 rs9584857 chr13:99128572 T/C cg20487152 chr13:99095054 FARP1 0.35 6.41 0.33 4.96e-10 Longevity; LUSC cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg10811474 chr19:8428787 ANGPTL4 -0.39 -5.97 -0.31 6.07e-9 HDL cholesterol; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg05896524 chr21:47604654 C21orf56 -0.57 -8.9 -0.44 3.65e-17 Testicular germ cell tumor; LUSC cis rs11018874 0.532 rs11018867 chr11:89862345 C/T cg14505434 chr11:89522851 NA 0.39 6.07 0.31 3.56e-9 White blood cell types; LUSC cis rs8141529 0.732 rs5762788 chr22:29174770 G/T cg15103426 chr22:29168792 CCDC117 0.57 7.88 0.4 4.68e-14 Lymphocyte counts; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg27284194 chr4:1044797 NA 0.35 5.83 0.3 1.32e-8 Obesity-related traits; LUSC cis rs17253792 0.822 rs79024594 chr14:56092997 T/G cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs738322 0.600 rs6001035 chr22:38562425 A/G cg25457927 chr22:38595422 NA -0.34 -6.8 -0.35 4.76e-11 Cutaneous nevi; LUSC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg18876405 chr7:65276391 NA -0.58 -9.51 -0.46 4.03e-19 Aortic root size; LUSC trans rs3733585 0.673 rs6449156 chr4:9956712 G/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.71e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs8044995 0.517 rs2863973 chr16:68409435 A/C cg05110241 chr16:68378359 PRMT7 -0.59 -7.28 -0.37 2.48e-12 Schizophrenia; LUSC cis rs6502050 0.761 rs13949 chr17:80059596 T/C cg13939156 chr17:80058883 NA 0.36 7.27 0.37 2.55e-12 Life satisfaction; LUSC trans rs7618501 0.602 rs6780731 chr3:50017478 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.57 8.96 0.44 2.36e-17 Intelligence (multi-trait analysis); LUSC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg04673462 chr1:38461896 NA 0.56 10.48 0.5 2.08e-22 Coronary artery disease; LUSC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg00701064 chr4:6280414 WFS1 0.58 14.15 0.61 6.19e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs11098499 0.738 rs28687057 chr4:120280812 A/G cg25214090 chr10:38739885 LOC399744 0.49 7.53 0.38 4.82e-13 Corneal astigmatism; LUSC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg13319975 chr6:146136371 FBXO30 0.49 7.33 0.37 1.73e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2734839 0.537 rs11214603 chr11:113279922 G/A cg14159747 chr11:113255604 NA 0.27 7.1 0.36 7.73e-12 Information processing speed; LUSC cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg04586622 chr2:25135609 ADCY3 0.4 8.37 0.42 1.6e-15 Body mass index; LUSC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs3857536 0.605 rs36040831 chr6:66876588 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.63 -9.2 -0.45 4.07e-18 Blood trace element (Cu levels); LUSC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg09085632 chr11:111637200 PPP2R1B -1.06 -16.96 -0.68 5.39e-47 Primary sclerosing cholangitis; LUSC cis rs1881396 0.945 rs1881395 chr2:27838549 G/A cg27432699 chr2:27873401 GPN1 0.65 8.8 0.43 7.39e-17 Nonalcoholic fatty liver disease; LUSC cis rs11229555 0.874 rs10896794 chr11:58339124 T/C cg15696309 chr11:58395628 NA -0.7 -9.06 -0.44 1.12e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs72781680 1.000 rs55982282 chr2:24188128 G/A cg08917208 chr2:24149416 ATAD2B 0.99 10.48 0.5 2.04e-22 Lymphocyte counts; LUSC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg22834771 chr12:69754056 YEATS4 -0.5 -7.45 -0.38 8.08e-13 Blood protein levels; LUSC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg06636001 chr8:8085503 FLJ10661 0.63 9.96 0.48 1.28e-20 Parkinson's disease; LUSC cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg09035930 chr12:129282057 SLC15A4 0.73 15.47 0.65 4.48e-41 Systemic lupus erythematosus; LUSC cis rs11153730 0.503 rs4946336 chr6:118632335 A/C cg21191810 chr6:118973309 C6orf204 0.34 5.77 0.3 1.78e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); LUSC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg00129232 chr17:37814104 STARD3 -0.48 -7.22 -0.37 3.56e-12 Asthma; LUSC cis rs6596100 0.538 rs67519234 chr5:132199359 C/A cg02081065 chr5:132209139 LEAP2 -0.62 -5.9 -0.31 9.1e-9 Breast cancer; LUSC cis rs5769765 0.542 rs738707 chr22:50250827 G/A cg02269571 chr22:50332266 NA 0.58 7.48 0.38 6.75e-13 Schizophrenia; LUSC cis rs854765 0.583 rs11650890 chr17:17790882 C/T cg16928487 chr17:17741425 SREBF1 0.45 8.85 0.44 5.16e-17 Total body bone mineral density; LUSC cis rs6121246 0.567 rs6087701 chr20:30217708 A/C cg13852791 chr20:30311386 BCL2L1 0.77 8.73 0.43 1.25e-16 Mean corpuscular hemoglobin; LUSC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg16624210 chr5:671434 TPPP 0.5 6.38 0.33 6.07e-10 Obesity-related traits; LUSC cis rs2629751 0.512 rs2723868 chr12:104422317 C/T cg14987745 chr12:104360022 TDG -0.69 -8.49 -0.42 6.79e-16 Hepatitis C induced liver fibrosis; LUSC cis rs9326248 0.581 rs7120515 chr11:116991926 A/G cg26566898 chr11:117069891 TAGLN 0.38 7.38 0.37 1.24e-12 Blood protein levels; LUSC cis rs7707921 0.767 rs862245 chr5:81585737 A/C cg15871215 chr5:81402204 ATG10 -0.46 -7.28 -0.37 2.37e-12 Breast cancer; LUSC cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg03146154 chr1:46216737 IPP 0.56 8.41 0.42 1.24e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs56283067 0.773 rs56115627 chr6:44683049 G/A cg18551225 chr6:44695536 NA -0.48 -8.36 -0.42 1.71e-15 Total body bone mineral density; LUSC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg20891283 chr12:69753455 YEATS4 0.81 14.65 0.63 7.13e-38 Blood protein levels; LUSC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg18404041 chr3:52824283 ITIH1 -0.58 -9.92 -0.48 1.69e-20 Schizophrenia; LUSC cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg21573476 chr21:45109991 RRP1B -0.36 -5.78 -0.3 1.72e-8 Mean corpuscular volume; LUSC cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg21535247 chr6:8435926 SLC35B3 0.58 8.89 0.44 3.79e-17 Motion sickness; LUSC cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg11584989 chr19:19387371 SF4 -0.5 -5.89 -0.31 9.61e-9 Bipolar disorder; LUSC cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs1997103 0.911 rs9642575 chr7:55399090 C/T cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs17507216 1.000 rs17158413 chr15:83235408 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.45 -6.13 -0.32 2.49e-9 Excessive daytime sleepiness; LUSC cis rs1775715 0.737 rs12256714 chr10:32216262 A/G cg03015672 chr10:32216066 ARHGAP12 -0.32 -5.66 -0.3 3.23e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4900538 0.821 rs8016191 chr14:102825340 G/A cg18135206 chr14:102964638 TECPR2 -0.99 -18.68 -0.71 7.96e-54 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg06238570 chr21:40685208 BRWD1 -0.48 -7.43 -0.38 9.18e-13 Cognitive function; LUSC cis rs1003719 0.586 rs2298685 chr21:38533390 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.45 -0.5 2.56e-22 Eye color traits; LUSC cis rs2219968 0.743 rs34849429 chr8:78909689 G/T cg00738934 chr8:78996279 NA -0.4 -7.2 -0.37 3.89e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg01652190 chr22:50026171 C22orf34 -0.29 -6.06 -0.31 3.77e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4776970 0.632 rs8030996 chr15:68031406 C/G cg08079166 chr15:68083412 MAP2K5 -0.38 -7.8 -0.39 7.74e-14 Waist circumference;Body mass index; LUSC cis rs4853012 0.887 rs2280642 chr2:74358252 T/A cg05776053 chr2:74358815 NA 0.49 7.71 0.39 1.43e-13 Gestational age at birth (maternal effect); LUSC cis rs3749237 0.964 rs2234385 chr3:49846041 G/A cg03060546 chr3:49711283 APEH 0.56 8.06 0.4 1.36e-14 Resting heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14589014 chr11:2952043 PHLDA2 0.42 6.2 0.32 1.65e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7849782 0.664 rs4742820 chr9:104394585 G/A cg22914338 chr19:14376960 NA 0.25 6.13 0.32 2.42e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs908922 0.676 rs11581947 chr1:152482587 G/A cg20991723 chr1:152506922 NA 0.52 9.8 0.47 4.32e-20 Hair morphology; LUSC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg02569458 chr12:86230093 RASSF9 0.59 10.15 0.49 2.81e-21 Major depressive disorder; LUSC cis rs6700896 0.931 rs10789193 chr1:66129646 A/T cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.91 -0.31 8.35e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg25258033 chr6:167368657 RNASET2 -0.47 -7.87 -0.4 5.12e-14 Crohn's disease; LUSC cis rs868036 0.609 rs28742003 chr15:68127769 C/T cg08079166 chr15:68083412 MAP2K5 0.47 7.68 0.39 1.78e-13 Restless legs syndrome; LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs727505 0.954 rs59670428 chr7:124520966 C/A cg23710748 chr7:124431027 NA -0.4 -7.18 -0.37 4.56e-12 Lewy body disease; LUSC cis rs3540 0.574 rs2256388 chr15:90969335 A/C cg10434728 chr15:90938212 IQGAP1 -0.38 -7.81 -0.39 7.72e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7178572 0.568 rs11632966 chr15:77621805 A/C cg22256960 chr15:77711686 NA -0.5 -8.04 -0.4 1.57e-14 Type 2 diabetes; LUSC cis rs7149337 0.836 rs4901087 chr14:51668499 T/C cg23942311 chr14:51606299 NA 0.46 10.06 0.48 5.75e-21 Cancer; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg13453750 chr1:205783389 SLC41A1 0.27 5.65 0.3 3.39e-8 Monocyte percentage of white cells; LUSC cis rs34638657 0.872 rs6420437 chr16:82187181 T/C cg09439754 chr16:82129088 HSD17B2 -0.41 -6.54 -0.34 2.37e-10 Lung adenocarcinoma; LUSC cis rs11677416 1.000 rs4848300 chr2:113527906 T/C cg27083787 chr2:113543245 IL1A 0.45 7.09 0.36 7.87e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs965604 1.000 rs1062980 chr15:78792527 T/C cg18825076 chr15:78729989 IREB2 0.45 7.1 0.36 7.64e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7264396 0.635 rs6060703 chr20:34529906 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.03 -0.44 1.45e-17 Total cholesterol levels; LUSC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg17264618 chr3:40429014 ENTPD3 0.33 6.95 0.36 1.91e-11 Renal cell carcinoma; LUSC cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg05347473 chr6:146136440 FBXO30 0.51 8.66 0.43 2e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg18252515 chr7:66147081 NA 1.23 14.01 0.61 2.04e-35 Diabetic kidney disease; LUSC cis rs4290604 0.665 rs4316893 chr2:238089767 T/C cg23555395 chr2:238036564 NA -0.46 -6.23 -0.32 1.4e-9 Asthma; LUSC cis rs11577318 0.853 rs1071849 chr1:26646726 A/G cg00852783 chr1:26633632 UBXN11 0.6 8.87 0.44 4.35e-17 Granulocyte percentage of myeloid white cells; LUSC cis rs7267979 1.000 rs6138572 chr20:25435934 G/C cg03522245 chr20:25566470 NINL 0.35 5.7 0.3 2.66e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs826838 0.967 rs826879 chr12:39088999 A/C cg13010199 chr12:38710504 ALG10B -0.65 -11.12 -0.52 1.18e-24 Heart rate; LUSC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg24675056 chr1:15929824 NA 0.44 7.52 0.38 5.13e-13 Systolic blood pressure; LUSC cis rs2486288 0.656 rs2413773 chr15:45549442 C/A cg09092052 chr15:45571596 NA 0.45 6.27 0.32 1.12e-9 Glomerular filtration rate; LUSC trans rs890100 0.643 rs12619332 chr2:56659016 T/A cg01657744 chr10:88471748 LDB3 0.43 5.95 0.31 6.75e-9 Gut microbiome composition (summer); LUSC trans rs2797160 0.967 rs1739368 chr6:126011079 C/T cg05039488 chr6:79577232 IRAK1BP1 0.47 6.99 0.36 1.53e-11 Endometrial cancer; LUSC cis rs8060686 0.545 rs76495028 chr16:68177036 G/C cg27539214 chr16:67997921 SLC12A4 -0.62 -7.43 -0.38 9.22e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg11941060 chr3:133502564 NA -0.47 -6.79 -0.35 5.27e-11 Iron status biomarkers; LUSC cis rs6429082 0.764 rs291377 chr1:235695186 C/T cg26050004 chr1:235667680 B3GALNT2 -0.57 -7.82 -0.39 7.03e-14 Adiposity; LUSC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg08200582 chr11:442649 ANO9 -0.55 -6.15 -0.32 2.16e-9 Body mass index; LUSC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg11812906 chr14:75593930 NEK9 0.66 11.49 0.53 5.68e-26 Height; LUSC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.35 7.79 0.39 8.81e-14 Hemoglobin concentration; LUSC cis rs12464483 0.591 rs2602775 chr2:30883012 C/T cg17749961 chr2:30669863 LCLAT1 0.67 8.37 0.42 1.62e-15 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg08859206 chr1:53392774 SCP2 0.52 9.03 0.44 1.39e-17 Monocyte count; LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg27284194 chr4:1044797 NA 0.34 5.72 0.3 2.33e-8 Obesity-related traits; LUSC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs2479724 0.846 rs2254805 chr6:41846110 T/G cg17623882 chr6:41773611 USP49 -0.61 -10.36 -0.49 5.25e-22 Menarche (age at onset); LUSC cis rs2559856 1.000 rs2695286 chr12:102088507 T/C cg12924262 chr12:102091054 CHPT1 0.43 6.12 0.32 2.57e-9 Blood protein levels; LUSC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9807841 0.592 rs10407349 chr19:10758453 G/A cg09936142 chr19:10668400 KRI1 -0.43 -6.95 -0.36 1.88e-11 Inflammatory skin disease; LUSC cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg05855489 chr10:104503620 C10orf26 0.53 7.73 0.39 1.25e-13 Arsenic metabolism; LUSC cis rs748404 0.697 rs473554 chr15:43568207 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.43 6.09 0.32 3.12e-9 Lung cancer; LUSC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg00815214 chr21:47717953 NA -0.4 -6.04 -0.31 4.12e-9 Testicular germ cell tumor; LUSC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg26597838 chr10:835615 NA 0.86 11.62 0.54 2e-26 Eosinophil percentage of granulocytes; LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs10089 1.000 rs17764954 chr5:127514436 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 10.5 0.5 1.81e-22 Ileal carcinoids; LUSC cis rs12956009 0.583 rs16951972 chr18:44898600 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.14 0.32 2.36e-9 Educational attainment (years of education); LUSC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg17971929 chr21:40555470 PSMG1 -0.65 -10.61 -0.5 7.42e-23 Cognitive function; LUSC cis rs12541635 1.000 rs1896919 chr8:107090357 C/G cg10147462 chr8:107024639 NA -0.48 -8.76 -0.43 1.03e-16 Age of smoking initiation; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.24 0.52 4.63e-25 Prudent dietary pattern; LUSC cis rs4776059 1.000 rs8026800 chr15:52933548 C/G cg22715398 chr15:52968154 KIAA1370 -0.7 -10.18 -0.49 2.23e-21 Schizophrenia; LUSC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -6.07 -0.32 3.38e-9 Tonsillectomy; LUSC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg04267008 chr7:1944627 MAD1L1 -0.48 -7.19 -0.37 4.27e-12 Bipolar disorder and schizophrenia; LUSC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg04546413 chr19:29218101 NA 0.72 11.5 0.53 5.38e-26 Methadone dose in opioid dependence; LUSC cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg25233709 chr10:116636983 FAM160B1 0.44 7.84 0.39 6.17e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg23978390 chr7:1156363 C7orf50 0.44 5.96 0.31 6.41e-9 Longevity;Endometriosis; LUSC cis rs4561483 0.831 rs33621 chr16:12008513 G/A cg08843971 chr16:11963173 GSPT1 -0.46 -6.81 -0.35 4.51e-11 Testicular germ cell tumor; LUSC cis rs7296418 0.663 rs4553407 chr12:123750748 G/C cg05973401 chr12:123451056 ABCB9 0.56 8.17 0.41 6.27e-15 Platelet count; LUSC trans rs61931739 0.500 rs7303318 chr12:34467789 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.6 0.6 7.86e-34 Morning vs. evening chronotype; LUSC cis rs4919694 0.536 rs12414777 chr10:104697781 C/T cg23093090 chr10:104574429 C10orf26 -0.4 -5.66 -0.3 3.31e-8 Arsenic metabolism; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg26354017 chr1:205819088 PM20D1 0.73 12.38 0.56 3.18e-29 Menarche (age at onset); LUSC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg04756594 chr16:24857601 SLC5A11 -0.5 -7.44 -0.38 8.85e-13 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs3931020 0.688 rs452242 chr1:75225625 G/T cg10128416 chr1:75198403 TYW3;CRYZ -0.62 -8.14 -0.41 8.11e-15 Resistin levels; LUSC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg17948913 chr5:572064 NA 0.33 5.81 0.3 1.43e-8 Obesity-related traits; LUSC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg05844789 chr1:228464394 OBSCN 0.3 5.7 0.3 2.57e-8 Diastolic blood pressure; LUSC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg00750074 chr16:89608354 SPG7 -0.56 -9.89 -0.48 2.15e-20 Multiple myeloma (IgH translocation); LUSC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs77741769 0.571 rs869781 chr12:121340246 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.64 0.43 2.3e-16 Mean corpuscular volume; LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.08 -0.32 3.35e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7677751 0.806 rs61320297 chr4:55088175 G/A cg17187183 chr4:55093834 PDGFRA 0.38 5.83 0.3 1.3e-8 Corneal astigmatism; LUSC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.53 0.34 2.51e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs10028773 0.666 rs12498657 chr4:120262866 G/C cg09307838 chr4:120376055 NA 0.64 9.67 0.47 1.19e-19 Educational attainment; LUSC cis rs9303401 0.614 rs28687626 chr17:57191904 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 12.59 0.57 4.98e-30 Cognitive test performance; LUSC cis rs2073300 1.000 rs6132625 chr20:23444671 C/T cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6062509 0.895 rs6011040 chr20:62337406 C/T cg01176363 chr20:62369445 LIME1 0.47 7.32 0.37 1.92e-12 Prostate cancer; LUSC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg10523679 chr1:76189770 ACADM 0.88 12.77 0.57 1.09e-30 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs7613875 0.578 rs4688753 chr3:50074773 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.83 -0.39 6.55e-14 Body mass index; LUSC cis rs9875589 0.509 rs4684174 chr3:14048375 C/T cg19554555 chr3:13937349 NA -0.38 -5.71 -0.3 2.47e-8 Ovarian reserve; LUSC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg00033643 chr7:134001901 SLC35B4 0.47 7.35 0.37 1.53e-12 Mean platelet volume; LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg02475777 chr4:1388615 CRIPAK 0.45 6.68 0.34 1.02e-10 Obesity-related traits; LUSC trans rs3733585 0.673 rs4519796 chr4:9955936 A/G cg26043149 chr18:55253948 FECH -0.45 -6.91 -0.35 2.43e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg06784218 chr1:46089804 CCDC17 0.48 9.45 0.46 6.3e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg09835421 chr16:68378352 PRMT7 -0.53 -5.9 -0.31 9e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg06494592 chr3:125709126 NA -0.5 -5.77 -0.3 1.86e-8 Blood pressure (smoking interaction); LUSC cis rs4363385 0.510 rs10888528 chr1:153050516 A/G cg25856811 chr1:152973957 SPRR3 0.36 5.97 0.31 5.91e-9 Inflammatory skin disease; LUSC cis rs1997103 1.000 rs10270618 chr7:55396712 T/A cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg22875332 chr1:76189707 ACADM -0.68 -9.28 -0.45 2.24e-18 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9560113 0.573 rs1888304 chr13:112242454 A/G cg10483660 chr13:112241077 NA 0.37 6.4 0.33 5.12e-10 Menarche (age at onset); LUSC trans rs7824557 0.734 rs2293856 chr8:11177447 C/T cg08975724 chr8:8085496 FLJ10661 0.47 6.89 0.35 2.75e-11 Retinal vascular caliber; LUSC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs7107174 1.000 rs2511158 chr11:77973980 C/T cg02023728 chr11:77925099 USP35 0.51 7.11 0.36 7.03e-12 Testicular germ cell tumor; LUSC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -7.94 -0.4 3.08e-14 Developmental language disorder (linguistic errors); LUSC cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg15839431 chr19:19639596 YJEFN3 -0.66 -7.28 -0.37 2.39e-12 Bipolar disorder; LUSC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg24578937 chr1:2090814 PRKCZ -0.41 -8.99 -0.44 1.82e-17 Height; LUSC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg25767906 chr1:53392781 SCP2 -0.4 -6.69 -0.34 9.53e-11 Monocyte count; LUSC cis rs12594515 0.874 rs8032878 chr15:45998015 A/G cg01629716 chr15:45996671 NA 0.4 5.96 0.31 6.25e-9 Waist circumference;Weight; LUSC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg17971929 chr21:40555470 PSMG1 -0.51 -7.58 -0.38 3.43e-13 Menarche (age at onset); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg11686214 chr19:59084984 MZF1;LOC100131691 -0.51 -6.02 -0.31 4.66e-9 Height; LUSC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg00290607 chr11:67383545 NA -0.32 -5.86 -0.31 1.09e-8 Mean corpuscular volume; LUSC cis rs12200560 0.505 rs2015196 chr6:97075331 G/C cg06623918 chr6:96969491 KIAA0776 0.5 7.2 0.37 3.9e-12 Coronary heart disease; LUSC cis rs601339 1.000 rs11059384 chr12:123170301 C/A cg11919336 chr12:123188078 GPR109A 0.42 6.22 0.32 1.45e-9 Adiponectin levels; LUSC cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg05347473 chr6:146136440 FBXO30 0.51 8.77 0.43 9.4e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs11758351 0.789 rs2069020 chr6:26205500 C/T cg01420254 chr6:26195488 NA 0.68 7.52 0.38 5.21e-13 Gout;Renal underexcretion gout; LUSC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg22920501 chr2:26401640 FAM59B 0.75 10.74 0.51 2.53e-23 Gut microbiome composition (summer); LUSC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg12016809 chr21:47604291 C21orf56 0.47 7.03 0.36 1.18e-11 Testicular germ cell tumor; LUSC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg11645453 chr3:52864694 ITIH4 0.58 14.03 0.61 1.85e-35 Schizophrenia; LUSC cis rs7267979 1.000 rs4815426 chr20:25405186 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC trans rs853679 0.882 rs9468287 chr6:28079741 G/T cg01620082 chr3:125678407 NA -0.6 -6.71 -0.34 8.4e-11 Depression; LUSC cis rs79839061 0.610 rs11726280 chr4:864077 C/T cg07828340 chr4:882639 GAK 1.08 11.43 0.53 9.63e-26 Intelligence (multi-trait analysis); LUSC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.63 -8.59 -0.43 3.4e-16 Systemic lupus erythematosus; LUSC cis rs3087591 0.960 rs2269855 chr17:29482878 G/A cg24425628 chr17:29625626 OMG;NF1 0.56 8.3 0.41 2.68e-15 Hip circumference; LUSC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -11.28 -0.53 3.1e-25 Systemic lupus erythematosus; LUSC cis rs9462027 0.606 rs1201874 chr6:34549810 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.03 -0.31 4.43e-9 Systemic lupus erythematosus; LUSC cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg13010199 chr12:38710504 ALG10B 0.66 9.97 0.48 1.11e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.31 0.49 8.3e-22 Bladder cancer; LUSC cis rs427394 1.000 rs274672 chr5:6744176 G/A cg10857441 chr5:6722123 POLS -0.41 -7.7 -0.39 1.6e-13 Menopause (age at onset); LUSC cis rs11711311 1.000 rs13061150 chr3:113506734 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.45 0.33 3.86e-10 IgG glycosylation; LUSC cis rs244293 1.000 rs244289 chr17:53231788 A/G cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.83 -0.3 1.34e-8 Menarche (age at onset); LUSC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg06808227 chr14:105710500 BRF1 -0.65 -9.82 -0.47 3.77e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg01181863 chr3:195395398 SDHAP2 -0.61 -8.25 -0.41 3.62e-15 Pancreatic cancer; LUSC trans rs11039798 1.000 rs10838918 chr11:48507449 A/G cg03929089 chr4:120376271 NA 0.69 6.43 0.33 4.38e-10 Axial length; LUSC cis rs62064224 0.720 rs8078837 chr17:30763537 A/G cg18200150 chr17:30822561 MYO1D 0.52 10.59 0.5 8.41e-23 Schizophrenia; LUSC cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg07606381 chr6:8435919 SLC35B3 0.75 12.62 0.57 3.88e-30 Motion sickness; LUSC cis rs9399135 0.507 rs2072825 chr6:135253451 A/G cg22676075 chr6:135203613 NA -0.65 -10.27 -0.49 1.13e-21 Red blood cell count; LUSC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg01283332 chr5:1856932 NA -0.32 -5.99 -0.31 5.55e-9 Cardiovascular disease risk factors; LUSC cis rs4363385 0.818 rs57311099 chr1:153005597 A/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.43e-12 Inflammatory skin disease; LUSC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.72 0.39 1.38e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg16405210 chr4:1374714 KIAA1530 -0.82 -14.19 -0.61 4.12e-36 Longevity; LUSC cis rs7759001 0.857 rs6934748 chr6:27354781 T/G cg18711553 chr6:27366782 ZNF391 0.39 5.76 0.3 1.96e-8 Glomerular filtration rate (creatinine); LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs10504229 0.679 rs16921683 chr8:58053270 T/C cg11062466 chr8:58055876 NA 0.51 6.7 0.34 8.73e-11 Developmental language disorder (linguistic errors); LUSC cis rs11605275 1.000 rs78091560 chr11:20032279 G/A cg14835545 chr11:20032148 NAV2 -0.86 -6.53 -0.34 2.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs477692 0.569 rs871028 chr10:131293478 C/T cg05714579 chr10:131428358 MGMT -0.42 -6.31 -0.33 9.03e-10 Response to temozolomide; LUSC cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg00033643 chr7:134001901 SLC35B4 0.42 6.14 0.32 2.37e-9 Mean platelet volume; LUSC cis rs6967385 0.934 rs7812164 chr7:12368389 A/T cg06484146 chr7:12443880 VWDE 0.4 5.84 0.3 1.21e-8 Response to taxane treatment (placlitaxel); LUSC cis rs7709377 0.620 rs10051302 chr5:115488698 G/C cg23108291 chr5:115420582 COMMD10 0.41 5.79 0.3 1.62e-8 Metabolite levels (X-11787); LUSC cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg22307029 chr19:49891270 CCDC155 0.58 8.32 0.41 2.32e-15 Multiple sclerosis; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg08736216 chr1:53307985 ZYG11A -0.28 -5.65 -0.3 3.41e-8 Monocyte count; LUSC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg01849466 chr14:104193079 ZFYVE21 -0.55 -7.88 -0.4 4.53e-14 Reticulocyte count; LUSC cis rs9911578 0.835 rs9303398 chr17:56484257 T/C cg12560992 chr17:57184187 TRIM37 -0.71 -12.61 -0.57 4.42e-30 Intelligence (multi-trait analysis); LUSC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg22903471 chr2:27725779 GCKR -0.4 -6.84 -0.35 3.67e-11 Total body bone mineral density; LUSC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg09365446 chr1:150670422 GOLPH3L 0.54 8.33 0.41 2.13e-15 Tonsillectomy; LUSC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.88 0.58 4.32e-31 Platelet count; LUSC cis rs12579753 0.956 rs35278765 chr12:82173126 T/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.97 -0.31 6.07e-9 Resting heart rate; LUSC cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -7.96 -0.4 2.78e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2905347 0.656 rs2051723 chr7:22665843 C/G cg23521230 chr7:22704884 NA 0.42 5.71 0.3 2.53e-8 Major depression and alcohol dependence; LUSC cis rs10754283 0.967 rs10801761 chr1:90115269 C/T cg21401794 chr1:90099060 LRRC8C 0.63 9.17 0.45 4.84e-18 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs2797160 0.874 rs58305111 chr6:126008386 G/T cg05901451 chr6:126070800 HEY2 0.57 8.51 0.42 5.97e-16 Endometrial cancer; LUSC trans rs62238980 0.614 rs76222062 chr22:32457049 T/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs7267979 0.780 rs6050679 chr20:25537827 A/T cg03522245 chr20:25566470 NINL 0.35 5.75 0.3 2.02e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg11141652 chr22:24348549 GSTTP1 0.41 6.28 0.32 1.08e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7223966 0.961 rs17631783 chr17:61687600 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.45 -6.1 -0.32 2.91e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs4423214 1.000 rs12793530 chr11:71161656 G/A cg05163923 chr11:71159392 DHCR7 0.74 11.04 0.52 2.38e-24 Vitamin D levels; LUSC cis rs427394 0.802 rs274721 chr5:6719164 C/T cg10857441 chr5:6722123 POLS -0.47 -9.21 -0.45 3.6e-18 Menopause (age at onset); LUSC cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg17366294 chr4:99064904 C4orf37 0.62 11.11 0.52 1.29e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26726542 chr13:20702031 NA -0.47 -5.95 -0.31 6.95e-9 Bipolar disorder and schizophrenia; LUSC cis rs273573 0.922 rs35194615 chr11:30813303 C/T cg14844989 chr11:31128820 NA -0.36 -5.72 -0.3 2.35e-8 Total body bone mineral density; LUSC cis rs11098499 0.754 rs1849457 chr4:120254355 A/G cg09307838 chr4:120376055 NA 0.68 10.33 0.49 6.9e-22 Corneal astigmatism; LUSC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg13531842 chr10:38383804 ZNF37A -0.43 -6.5 -0.34 2.95e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.64 0.39 2.31e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9309473 0.607 rs4641966 chr2:73590806 G/A cg20560298 chr2:73613845 ALMS1 -0.55 -8.06 -0.4 1.39e-14 Metabolite levels; LUSC cis rs877282 0.891 rs34652870 chr10:772218 T/C cg17470449 chr10:769945 NA 0.53 7.31 0.37 1.98e-12 Uric acid levels; LUSC cis rs1559088 0.948 rs12610071 chr19:33582687 A/C cg27124370 chr19:33622961 WDR88 0.57 7.42 0.38 1.01e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg07092213 chr7:1199455 ZFAND2A -0.67 -10.97 -0.51 4e-24 Longevity;Endometriosis; LUSC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg16624210 chr5:671434 TPPP 0.49 6.11 0.32 2.72e-9 Lung disease severity in cystic fibrosis; LUSC cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -8.96 -0.44 2.41e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg23262073 chr20:60523788 NA -0.44 -6.52 -0.34 2.6e-10 Body mass index; LUSC trans rs79057730 0.599 rs9458 chr7:825494 A/G cg26647312 chr5:1645268 NA -0.6 -5.98 -0.31 5.6e-9 Initial pursuit acceleration; LUSC cis rs2279817 1.000 rs1339801 chr1:18020298 A/G cg21791023 chr1:18019539 ARHGEF10L 0.44 6.47 0.33 3.51e-10 Neuroticism; LUSC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg02269571 chr22:50332266 NA 0.59 8.79 0.43 8.05e-17 Schizophrenia; LUSC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg13319975 chr6:146136371 FBXO30 -0.68 -10.57 -0.5 1.05e-22 Lobe attachment (rater-scored or self-reported); LUSC trans rs953492 0.672 rs1766030 chr1:243314577 C/T cg04438194 chr4:119512985 NA -0.41 -6.19 -0.32 1.8e-9 Diastolic blood pressure; LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg22920501 chr2:26401640 FAM59B -0.82 -12.42 -0.56 2.25e-29 Gut microbiome composition (summer); LUSC cis rs17270561 0.636 rs6923839 chr6:25745853 G/A cg16482183 chr6:26056742 HIST1H1C 0.65 9.03 0.44 1.43e-17 Iron status biomarkers; LUSC cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg19628046 chr18:33552617 C18orf21 0.52 6.12 0.32 2.59e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg17541715 chr7:1216824 NA -0.36 -5.69 -0.3 2.83e-8 Longevity;Endometriosis; LUSC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.51 -7.94 -0.4 3.01e-14 Colorectal cancer; LUSC cis rs35146811 0.696 rs1727124 chr7:99804104 T/G cg19116668 chr7:99932089 PMS2L1 0.33 5.7 0.3 2.64e-8 Coronary artery disease; LUSC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC cis rs10504073 0.669 rs818560 chr8:50035417 C/T cg00325661 chr8:49890786 NA 0.6 9.75 0.47 6.18e-20 Blood metabolite ratios; LUSC cis rs7666738 0.546 rs34621463 chr4:98793357 G/C cg03676636 chr4:99064102 C4orf37 0.3 5.99 0.31 5.55e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg24060327 chr5:131705240 SLC22A5 -0.37 -6.08 -0.32 3.29e-9 Blood metabolite levels; LUSC cis rs12681287 0.640 rs2953516 chr8:87332545 C/T cg27223183 chr8:87520930 FAM82B -0.51 -6.62 -0.34 1.43e-10 Caudate activity during reward; LUSC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg17330251 chr7:94953956 PON1 -0.38 -6.02 -0.31 4.69e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs8072100 0.935 rs12943464 chr17:45690351 A/T cg03886242 chr7:26192032 NFE2L3 0.37 6.25 0.32 1.22e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2180341 0.538 rs4392733 chr6:127712603 T/C cg24812749 chr6:127587940 RNF146 0.49 7.19 0.37 4.33e-12 Breast cancer; LUSC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg10802521 chr3:52805072 NEK4 -0.57 -9.39 -0.46 9.84e-19 Electroencephalogram traits; LUSC trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.97 -0.36 1.73e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs4144743 1.000 rs72823474 chr17:45321776 G/C cg18085866 chr17:45331354 ITGB3 -0.75 -8.07 -0.4 1.24e-14 Body mass index; LUSC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg09796270 chr17:17721594 SREBF1 0.39 6.74 0.35 7.12e-11 Total body bone mineral density; LUSC trans rs2739330 0.732 rs5760175 chr22:24399655 T/G cg06437703 chr8:37914619 EIF4EBP1 -0.68 -11.72 -0.54 8.38e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2303282 0.664 rs2432540 chr16:56419628 A/G cg00500540 chr16:56394104 NA 0.4 6.76 0.35 6.21e-11 Breast cancer; LUSC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg21435336 chr19:17392852 ANKLE1 -0.44 -6.12 -0.32 2.69e-9 Systemic lupus erythematosus; LUSC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg11764359 chr7:65958608 NA -0.7 -10.95 -0.51 4.58e-24 Aortic root size; LUSC cis rs10504229 0.679 rs78941440 chr8:58052095 A/G cg08219700 chr8:58056026 NA 0.44 5.82 0.3 1.35e-8 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04767207 chr11:60929031 VPS37C 0.49 6.86 0.35 3.44e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs290268 0.669 rs10993693 chr9:93557698 C/T cg02608019 chr9:93564028 SYK 0.52 8.6 0.43 3.13e-16 Platelet count; LUSC cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.64 -0.6 5.38e-34 Chronic sinus infection; LUSC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg00784671 chr22:46762841 CELSR1 -0.47 -5.97 -0.31 6.02e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7772486 0.875 rs2748485 chr6:146332421 T/C cg23711669 chr6:146136114 FBXO30 0.85 15.62 0.65 1.15e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg15112475 chr7:1198522 ZFAND2A -0.3 -6.04 -0.31 4.15e-9 Longevity;Endometriosis; LUSC cis rs10504073 0.525 rs10081464 chr8:50058707 A/G cg00325661 chr8:49890786 NA 0.47 7.0 0.36 1.43e-11 Blood metabolite ratios; LUSC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.28 0.33 1.04e-9 Multiple sclerosis; LUSC cis rs7903847 0.642 rs12415424 chr10:99117897 C/A cg20016023 chr10:99160130 RRP12 -0.3 -6.3 -0.33 9.27e-10 Granulocyte percentage of myeloid white cells; LUSC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg18876405 chr7:65276391 NA 0.67 11.85 0.54 2.92e-27 Aortic root size; LUSC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg20891283 chr12:69753455 YEATS4 -0.9 -17.6 -0.69 1.54e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg22920501 chr2:26401640 FAM59B -0.75 -10.64 -0.5 5.79e-23 Gut microbiome composition (summer); LUSC cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.81 0.39 7.68e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2625529 0.556 rs8038007 chr15:72568043 C/G cg16672083 chr15:72433130 SENP8 0.46 7.48 0.38 6.55e-13 Red blood cell count; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg27267900 chr19:1924559 SCAMP4 -0.69 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg23172400 chr8:95962367 TP53INP1 -0.32 -5.93 -0.31 7.76e-9 Type 2 diabetes; LUSC cis rs2486288 0.656 rs9921035 chr15:45546660 C/T cg04036182 chr15:45458818 NA -0.37 -6.01 -0.31 4.99e-9 Glomerular filtration rate; LUSC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03517284 chr6:25882590 NA -0.46 -7.93 -0.4 3.32e-14 Intelligence (multi-trait analysis); LUSC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg06808227 chr14:105710500 BRF1 -0.67 -10.31 -0.49 8.31e-22 Mean platelet volume;Platelet distribution width; LUSC cis rs244731 0.959 rs4976677 chr5:176629546 G/A cg17509989 chr5:176798049 RGS14 -0.68 -9.67 -0.47 1.16e-19 Urate levels in lean individuals; LUSC cis rs41271473 0.898 rs12028277 chr1:228829657 A/G cg16512390 chr1:228756714 NA 0.57 7.03 0.36 1.19e-11 Chronic lymphocytic leukemia; LUSC trans rs11148252 0.740 rs9526914 chr13:52976300 G/T cg18335740 chr13:41363409 SLC25A15 0.59 9.16 0.45 5.36e-18 Lewy body disease; LUSC cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg26384229 chr12:38710491 ALG10B 0.94 17.87 0.7 1.34e-50 Heart rate; LUSC cis rs4654899 0.865 rs72975078 chr1:21476196 A/G cg02927042 chr1:21476669 EIF4G3 -0.36 -5.76 -0.3 1.88e-8 Superior frontal gyrus grey matter volume; LUSC cis rs662735 0.515 rs2022130 chr11:30819811 T/C cg14844989 chr11:31128820 NA -0.37 -5.86 -0.31 1.11e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg08736216 chr1:53307985 ZYG11A 0.3 6.19 0.32 1.78e-9 Monocyte count; LUSC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg05368731 chr17:41323189 NBR1 0.93 15.52 0.65 2.8e-41 Menopause (age at onset); LUSC cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg22676075 chr6:135203613 NA -0.58 -9.28 -0.45 2.22e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs3008870 0.755 rs3929738 chr1:67397865 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.74 12.09 0.55 3.59e-28 Lymphocyte percentage of white cells; LUSC cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg22782873 chr19:19639568 YJEFN3 -0.46 -6.12 -0.32 2.63e-9 Bipolar disorder; LUSC cis rs10743315 0.557 rs74478800 chr12:19367517 A/T cg02471346 chr12:19282374 PLEKHA5 0.78 6.28 0.33 1.03e-9 Gut microbiota (bacterial taxa); LUSC cis rs10788264 0.544 rs911786 chr10:124017583 C/G cg09507567 chr10:124027408 NA 0.54 9.4 0.46 9.12e-19 Total body bone mineral density; LUSC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.86 0.47 2.69e-20 Personality dimensions; LUSC cis rs2346177 0.874 rs4953372 chr2:46651624 C/G cg02822958 chr2:46747628 ATP6V1E2 -0.34 -5.94 -0.31 7.01e-9 HDL cholesterol; LUSC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg26408565 chr15:76604113 ETFA -0.47 -7.42 -0.38 9.75e-13 Blood metabolite levels; LUSC cis rs939574 1.000 rs3817424 chr2:220096903 A/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.07 8.71 0.43 1.42e-16 Platelet distribution width; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg11645453 chr3:52864694 ITIH4 0.35 8.37 0.42 1.63e-15 Bipolar disorder; LUSC cis rs73198271 0.855 rs57301822 chr8:8608642 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -5.98 -0.31 5.63e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg03188948 chr7:1209495 NA 0.67 7.1 0.36 7.38e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.46e-23 Gut microbiome composition (summer); LUSC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg20406979 chr6:167373233 NA 0.25 5.69 0.3 2.76e-8 Crohn's disease; LUSC cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg11189052 chr15:85197271 WDR73 0.5 6.39 0.33 5.74e-10 Schizophrenia; LUSC cis rs11623869 0.614 rs11627052 chr14:103863476 A/G cg12935359 chr14:103987150 CKB 0.64 8.39 0.42 1.34e-15 Bone mineral density; LUSC cis rs3770081 1.000 rs17584578 chr2:86307624 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 1.03 7.43 0.38 9.06e-13 Facial emotion recognition (sad faces); LUSC cis rs3849570 0.925 rs2873054 chr3:81888255 A/C cg07356753 chr3:81810745 GBE1 -0.68 -10.95 -0.51 4.75e-24 Waist circumference;Body mass index; LUSC cis rs752010 0.574 rs10890161 chr1:42121623 T/C cg06885757 chr1:42089581 HIVEP3 0.44 9.33 0.45 1.49e-18 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs394563 0.591 rs237029 chr6:149717425 A/G cg11245181 chr6:149772854 ZC3H12D -0.3 -6.4 -0.33 5.38e-10 Dupuytren's disease; LUSC cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg17063962 chr7:91808500 NA 0.6 9.45 0.46 5.98e-19 Breast cancer; LUSC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.58 0.34 1.86e-10 Lung cancer; LUSC cis rs250677 0.687 rs250678 chr5:148434830 C/T cg23229984 chr5:148520753 ABLIM3 0.38 5.93 0.31 7.63e-9 Breast cancer; LUSC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.14 -0.8 3.2e-75 Height; LUSC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg21028142 chr17:79581711 NPLOC4 0.35 8.24 0.41 4.03e-15 Eye color traits; LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.27e-22 Body mass index; LUSC cis rs1348850 0.645 rs11887886 chr2:178425730 C/T cg22681709 chr2:178499509 PDE11A -0.4 -6.18 -0.32 1.91e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs2797160 1.000 rs2747720 chr6:126009458 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg24642439 chr20:33292090 TP53INP2 0.49 7.42 0.38 9.86e-13 Glomerular filtration rate (creatinine); LUSC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg07507251 chr3:52567010 NT5DC2 0.34 6.55 0.34 2.21e-10 Bipolar disorder; LUSC trans rs11098499 0.863 rs3775843 chr4:120427844 T/C cg25214090 chr10:38739885 LOC399744 0.5 7.39 0.37 1.19e-12 Corneal astigmatism; LUSC cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg11244672 chr19:19639970 YJEFN3 -0.55 -6.84 -0.35 3.86e-11 Bipolar disorder; LUSC cis rs55794721 0.509 rs12027135 chr1:25775733 A/T cg27572855 chr1:25598939 RHD 0.43 7.69 0.39 1.69e-13 Plateletcrit;Mean corpuscular volume; LUSC cis rs977987 0.806 rs11862684 chr16:75461746 T/G cg03315344 chr16:75512273 CHST6 0.51 9.57 0.46 2.55e-19 Dupuytren's disease; LUSC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.88 -0.4 4.57e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg16145915 chr7:1198662 ZFAND2A 0.43 7.77 0.39 9.61e-14 Longevity;Endometriosis; LUSC cis rs950027 0.787 rs2433616 chr15:45728599 A/G cg14582100 chr15:45693742 SPATA5L1 0.4 7.34 0.37 1.66e-12 Response to fenofibrate (adiponectin levels); LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg22166914 chr1:53195759 ZYG11B -0.48 -7.5 -0.38 5.93e-13 Monocyte count; LUSC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1372520 0.935 rs1372519 chr4:90757309 A/G cg14346243 chr4:90757452 SNCA -0.43 -6.21 -0.32 1.61e-9 Neuroticism; LUSC cis rs7666738 0.716 rs11097615 chr4:99092773 T/C cg17366294 chr4:99064904 C4orf37 0.53 9.12 0.45 7.31e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg23262073 chr20:60523788 NA -0.46 -6.76 -0.35 6.33e-11 Body mass index; LUSC cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg22509189 chr2:225307070 NA -0.47 -6.13 -0.32 2.55e-9 IgE levels in asthmatics (D.p. specific); LUSC trans rs10435719 0.899 rs9693925 chr8:11789963 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.09 0.4 1.12e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs472402 0.623 rs8192135 chr5:6636757 T/A cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.51 -7.69 -0.39 1.66e-13 Response to amphetamines; LUSC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.52 0.34 2.54e-10 Intelligence (multi-trait analysis); LUSC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg20135002 chr11:47629003 NA -0.52 -8.21 -0.41 5e-15 Subjective well-being; LUSC cis rs10751667 1.000 rs7396366 chr11:986185 C/A cg01483505 chr11:975446 AP2A2 0.44 6.12 0.32 2.64e-9 Alzheimer's disease (late onset); LUSC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg22029157 chr1:209979665 IRF6 0.76 9.84 0.47 3.17e-20 Cleft lip with or without cleft palate; LUSC cis rs1577917 0.958 rs7382798 chr6:86559834 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg00129232 chr17:37814104 STARD3 -0.5 -7.4 -0.38 1.11e-12 Asthma; LUSC trans rs7786808 0.741 rs4909222 chr7:158228095 C/T cg02030672 chr11:45687055 CHST1 -0.41 -6.31 -0.33 8.65e-10 Obesity-related traits; LUSC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg06027949 chr8:82754900 SNX16 -0.45 -6.42 -0.33 4.7e-10 Diastolic blood pressure; LUSC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg11608241 chr8:8085544 FLJ10661 0.38 5.72 0.3 2.31e-8 Mood instability; LUSC cis rs6580649 0.941 rs57054831 chr12:48486892 C/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg27211696 chr2:191398769 TMEM194B 0.61 11.79 0.54 4.5e-27 Pulse pressure; LUSC cis rs7582180 0.676 rs11691135 chr2:100934038 C/T cg14675211 chr2:100938903 LONRF2 0.37 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg19748678 chr4:122722346 EXOSC9 0.51 7.8 0.39 7.9e-14 Type 2 diabetes; LUSC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.54 -0.38 4.39e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.872 rs5770604 chr22:50030672 G/A cg01652190 chr22:50026171 C22orf34 -0.28 -5.72 -0.3 2.36e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs68170813 0.559 rs1548523 chr7:106944408 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.65 -0.3 3.5e-8 Coronary artery disease; LUSC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -12.06 -0.55 4.59e-28 Type 2 diabetes; LUSC cis rs796364 0.625 rs13035260 chr2:201132377 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.49 -5.7 -0.3 2.69e-8 Schizophrenia; LUSC cis rs17401966 0.522 rs17396973 chr1:10334924 C/T cg17425144 chr1:10567563 PEX14 -0.32 -5.83 -0.3 1.34e-8 Hepatocellular carcinoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03738868 chr7:100281714 GIGYF1 -0.81 -6.61 -0.34 1.51e-10 Cognitive performance; LUSC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg12963246 chr6:28129442 ZNF389 0.52 7.2 0.37 3.93e-12 Parkinson's disease; LUSC cis rs3768617 0.510 rs10797838 chr1:183077020 A/G ch.1.3577855R chr1:183094577 LAMC1 0.7 11.02 0.52 2.77e-24 Fuchs's corneal dystrophy; LUSC cis rs7216064 0.773 rs74541577 chr17:65853651 C/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.25 -0.45 2.79e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC trans rs4252134 0.959 rs4252090 chr6:161133544 A/T cg15416064 chr12:49209402 NA -0.43 -6.04 -0.31 4.18e-9 Giant cell arteritis; LUSC cis rs56804039 1.000 rs7017341 chr8:8381664 C/A cg06636001 chr8:8085503 FLJ10661 -0.51 -6.24 -0.32 1.32e-9 Cervical cancer; LUSC cis rs11051970 0.704 rs7312698 chr12:32554695 G/T cg02745156 chr12:32552066 NA 0.37 6.8 0.35 4.69e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7241530 0.636 rs4798996 chr18:75889558 G/A cg14642773 chr18:75888474 NA 0.36 5.93 0.31 7.46e-9 Educational attainment (years of education); LUSC cis rs540254 0.619 rs4656270 chr1:160779412 A/G cg20255094 chr1:160771763 LY9 0.55 6.64 0.34 1.24e-10 Blood protein levels; LUSC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg12751644 chr20:60527061 NA -0.33 -6.22 -0.32 1.46e-9 Body mass index; LUSC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg13206674 chr6:150067644 NUP43 0.64 10.48 0.5 2.17e-22 Lung cancer; LUSC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg01802117 chr1:53393560 SCP2 0.46 7.51 0.38 5.33e-13 Monocyte count; LUSC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg04352962 chr1:209979756 IRF6 0.52 7.09 0.36 7.81e-12 Cleft lip with or without cleft palate; LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg18404041 chr3:52824283 ITIH1 -0.57 -11.03 -0.52 2.41e-24 Bipolar disorder; LUSC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg14019146 chr3:50243930 SLC38A3 0.32 7.07 0.36 9.29e-12 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg05896524 chr21:47604654 C21orf56 0.5 7.74 0.39 1.17e-13 Testicular germ cell tumor; LUSC trans rs4332037 0.906 rs6461009 chr7:1952139 T/C cg10840412 chr1:235813424 GNG4 -0.66 -9.08 -0.44 9.63e-18 Bipolar disorder; LUSC cis rs4919087 0.715 rs8181326 chr10:98998195 G/A cg25902810 chr10:99078978 FRAT1 0.39 5.68 0.3 2.99e-8 Monocyte count; LUSC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg25208724 chr1:156163844 SLC25A44 1.1 26.73 0.83 5.84e-85 Testicular germ cell tumor; LUSC cis rs2742417 1.000 rs2673034 chr3:45755138 A/G cg04837898 chr3:45731254 SACM1L -0.34 -5.73 -0.3 2.26e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg04586622 chr2:25135609 ADCY3 -0.36 -7.57 -0.38 3.6e-13 Body mass index in non-asthmatics; LUSC cis rs72960926 0.744 rs72950546 chr6:74907293 A/T cg03266952 chr6:74778945 NA -0.78 -6.3 -0.33 9.2e-10 Metabolite levels (MHPG); LUSC cis rs7917772 0.582 rs10883753 chr10:104372441 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.11 0.52 1.28e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.69 0.39 1.65e-13 Bipolar disorder; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg00945038 chr17:61921165 SMARCD2 0.53 9.54 0.46 3.22e-19 Prudent dietary pattern; LUSC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg25643088 chr3:52874325 TMEM110 0.39 5.82 0.3 1.4e-8 Schizophrenia; LUSC cis rs7264396 0.790 rs761826 chr20:34194243 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -7.97 -0.4 2.58e-14 Total cholesterol levels; LUSC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg09365446 chr1:150670422 GOLPH3L 0.49 7.33 0.37 1.8e-12 Melanoma; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg01802117 chr1:53393560 SCP2 -0.37 -6.02 -0.31 4.52e-9 Monocyte count; LUSC cis rs11018904 0.817 rs11606060 chr11:89928597 T/C cg26834418 chr11:89957033 CHORDC1 -0.51 -6.02 -0.31 4.67e-9 Intelligence (multi-trait analysis); LUSC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg11812906 chr14:75593930 NEK9 0.66 11.34 0.53 2.04e-25 Height; LUSC cis rs7712401 0.584 rs39820 chr5:122299921 G/A cg19077854 chr5:122220652 SNX24 0.43 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs34330 0.562 rs11055023 chr12:12853197 A/G cg09462578 chr12:12878428 APOLD1 -0.68 -7.89 -0.4 4.41e-14 Systemic lupus erythematosus; LUSC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg26769984 chr7:1090371 C7orf50 0.72 10.19 0.49 2.05e-21 Bronchopulmonary dysplasia; LUSC cis rs1568889 1.000 rs12794100 chr11:28332785 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 8.74 0.43 1.11e-16 Bipolar disorder; LUSC cis rs7267979 0.903 rs1118963 chr20:25247449 G/A cg08601574 chr20:25228251 PYGB 0.47 7.29 0.37 2.28e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10992471 0.603 rs12336415 chr9:95195458 G/T cg14631576 chr9:95140430 CENPP -0.35 -6.48 -0.33 3.26e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9326248 0.559 rs482371 chr11:116752163 T/C cg20608306 chr11:116969690 SIK3 0.37 6.92 0.35 2.28e-11 Blood protein levels; LUSC cis rs59104589 0.517 rs3821281 chr2:242385340 A/G cg14842376 chr2:242211374 HDLBP 0.53 6.19 0.32 1.81e-9 Fibrinogen levels; LUSC cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs12891047 0.804 rs11626769 chr14:68291467 G/A cg20999565 chr14:68265668 ZFYVE26 0.38 5.8 0.3 1.54e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9300255 0.602 rs1790116 chr12:123618544 G/T cg05973401 chr12:123451056 ABCB9 0.54 6.71 0.34 8.23e-11 Neutrophil percentage of white cells; LUSC cis rs3772130 0.583 rs34051021 chr3:121433005 C/A cg20356878 chr3:121714668 ILDR1 0.51 8.14 0.41 7.72e-15 Cognitive performance; LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.62 7.16 0.36 5.11e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.78 0.6 1.67e-34 Chronic sinus infection; LUSC cis rs4919694 1.000 rs12257941 chr10:104833161 C/T cg04362960 chr10:104952993 NT5C2 1.18 14.04 0.61 1.62e-35 Arsenic metabolism; LUSC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg19729930 chr2:74357872 NA 0.87 16.62 0.67 1.21e-45 Gestational age at birth (maternal effect); LUSC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.7 -11.03 -0.52 2.39e-24 Menarche (age at onset); LUSC cis rs6982240 0.514 rs10481391 chr8:142277149 A/G cg00131261 chr8:142287264 NA -0.38 -6.25 -0.32 1.28e-9 Tonsillectomy; LUSC cis rs16866061 0.515 rs3738951 chr2:225368321 A/G cg12698349 chr2:225449008 CUL3 1.0 20.02 0.74 3.92e-59 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs4494114 1.000 rs4607833 chr1:39354272 G/C cg25970120 chr1:39325951 RRAGC -0.4 -6.19 -0.32 1.8e-9 Blood protein levels; LUSC cis rs951366 0.576 rs1832775 chr1:205734032 C/T cg11965913 chr1:205819406 PM20D1 -0.48 -6.67 -0.34 1.08e-10 Menarche (age at onset); LUSC cis rs722599 0.683 rs2302834 chr14:75279395 T/A cg08847533 chr14:75593920 NEK9 0.45 6.4 0.33 5.18e-10 IgG glycosylation; LUSC trans rs3942852 0.868 rs7118232 chr11:48106274 T/C cg03929089 chr4:120376271 NA -0.52 -6.05 -0.31 3.94e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs834811 0.796 rs2349456 chr7:135901545 G/T cg01726295 chr7:135938950 NA -0.39 -7.03 -0.36 1.19e-11 Post-traumatic stress disorder; LUSC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg08280861 chr8:58055591 NA 0.52 6.8 0.35 4.9e-11 Developmental language disorder (linguistic errors); LUSC cis rs7824557 0.564 rs6601584 chr8:11232343 C/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.81 -0.3 1.46e-8 Retinal vascular caliber; LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg16405210 chr4:1374714 KIAA1530 -0.57 -8.77 -0.43 8.98e-17 Obesity-related traits; LUSC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg03538708 chr1:25844672 NA -0.37 -6.22 -0.32 1.47e-9 Erythrocyte sedimentation rate; LUSC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg05425664 chr17:57184151 TRIM37 -0.56 -8.29 -0.41 2.84e-15 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg11218175 chr11:495084 RNH1 -0.5 -5.66 -0.3 3.22e-8 Body mass index; LUSC cis rs714027 1.000 rs5763767 chr22:30493882 G/A cg11564601 chr22:30592435 NA -0.37 -6.95 -0.36 1.91e-11 Lymphocyte counts; LUSC cis rs1957429 0.520 rs2181127 chr14:65336455 C/T cg23373153 chr14:65346875 NA -0.87 -7.56 -0.38 4.04e-13 Pediatric areal bone mineral density (radius); LUSC cis rs11583043 1.000 rs12567858 chr1:101517688 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.42 5.79 0.3 1.62e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4076764 0.535 rs4409627 chr1:163382050 A/G cg24596788 chr1:163392923 NA 0.36 6.35 0.33 7.21e-10 Motion sickness; LUSC cis rs1371867 0.846 rs1660317 chr8:101333252 G/T cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs9326248 0.861 rs7120449 chr11:117042899 T/C cg01368799 chr11:117014884 PAFAH1B2 0.46 5.66 0.3 3.2e-8 Blood protein levels; LUSC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg11189052 chr15:85197271 WDR73 -0.53 -7.51 -0.38 5.32e-13 P wave terminal force; LUSC cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg00321850 chr1:175162397 KIAA0040 0.46 7.98 0.4 2.36e-14 Alcohol dependence; LUSC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg15649852 chr7:65879115 NA -0.41 -5.75 -0.3 2.02e-8 Aortic root size; LUSC cis rs12310956 0.510 rs6488178 chr12:33885251 C/G cg06521331 chr12:34319734 NA -0.37 -6.16 -0.32 2.06e-9 Morning vs. evening chronotype; LUSC trans rs8072100 0.967 rs62076549 chr17:45579555 T/G cg03886242 chr7:26192032 NFE2L3 0.37 6.01 0.31 4.9e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg22782873 chr19:19639568 YJEFN3 0.52 6.43 0.33 4.48e-10 Bipolar disorder; LUSC cis rs11051970 0.879 rs10844201 chr12:32575029 A/G cg02745156 chr12:32552066 NA 0.43 7.24 0.37 3.02e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6845621 0.835 rs11736810 chr4:18937568 C/T cg12196642 chr4:18937545 NA -0.36 -6.71 -0.34 8.42e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs3740393 0.562 rs11191389 chr10:104523018 C/T cg05855489 chr10:104503620 C10orf26 0.56 5.84 0.3 1.24e-8 Microalbuminuria; LUSC cis rs78579285 0.584 rs34908386 chr16:88800913 C/T cg01900006 chr16:88814613 FAM38A 0.6 6.75 0.35 6.42e-11 Joint mobility (Beighton score); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg11021200 chr13:21750354 SKA3;MRP63 0.45 6.44 0.33 4.06e-10 Triglycerides; LUSC cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.41e-9 Crohn's disease; LUSC cis rs8013055 0.898 rs8014913 chr14:105977313 T/C cg19700328 chr14:106028568 NA -0.41 -6.89 -0.35 2.83e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg11344533 chr11:111475393 SIK2 -0.49 -6.87 -0.35 3.18e-11 Primary sclerosing cholangitis; LUSC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg23711669 chr6:146136114 FBXO30 -0.72 -10.32 -0.49 7.28e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg15147215 chr3:52552868 STAB1 0.31 6.08 0.32 3.33e-9 Bipolar disorder; LUSC cis rs67366981 1.000 rs2287379 chr14:77705411 A/C cg22824376 chr14:77648248 TMEM63C 0.67 6.3 0.33 9.16e-10 Obsessive-compulsive symptoms; LUSC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs921665 0.584 rs5019161 chr2:3174761 A/G cg02624386 chr2:3182749 NA 0.6 6.73 0.35 7.43e-11 World class endurance athleticism; LUSC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg11764359 chr7:65958608 NA -0.8 -13.41 -0.59 4.21e-33 Aortic root size; LUSC cis rs6964587 1.000 rs9785013 chr7:91674302 G/A cg17063962 chr7:91808500 NA 0.56 9.01 0.44 1.58e-17 Breast cancer; LUSC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg00677455 chr12:58241039 CTDSP2 0.59 8.48 0.42 7.35e-16 Multiple sclerosis; LUSC cis rs4363385 0.747 rs1577963 chr1:152961882 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.64 -0.39 2.25e-13 Inflammatory skin disease; LUSC cis rs244293 0.965 rs244301 chr17:53239140 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.41 -5.93 -0.31 7.63e-9 Menarche (age at onset); LUSC cis rs748404 0.697 rs491804 chr15:43560825 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.4 5.75 0.3 2.04e-8 Lung cancer; LUSC cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg06484146 chr7:12443880 VWDE -0.57 -6.07 -0.31 3.57e-9 Coronary artery disease; LUSC cis rs6088580 0.505 rs6058106 chr20:33278255 T/C cg07148914 chr20:33460835 GGT7 -0.55 -8.43 -0.42 1.06e-15 Glomerular filtration rate (creatinine); LUSC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg22823121 chr1:150693482 HORMAD1 0.51 7.44 0.38 8.56e-13 Melanoma; LUSC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg12257692 chr3:49977190 RBM6 0.25 6.96 0.36 1.76e-11 Body mass index; LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg23281280 chr6:28129359 ZNF389 0.49 6.24 0.32 1.34e-9 Parkinson's disease; LUSC cis rs4595586 0.563 rs2388178 chr12:39364366 T/G cg26384229 chr12:38710491 ALG10B 0.5 7.2 0.37 3.91e-12 Morning vs. evening chronotype; LUSC cis rs7215564 0.818 rs4890054 chr17:78587195 C/T cg23238734 chr17:78661607 RPTOR 0.49 5.97 0.31 6.07e-9 Myopia (pathological); LUSC cis rs736408 0.500 rs2878762 chr3:52919002 T/C cg18404041 chr3:52824283 ITIH1 -0.58 -9.48 -0.46 4.98e-19 Bipolar disorder; LUSC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg00701064 chr4:6280414 WFS1 -0.59 -14.58 -0.62 1.37e-37 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7659604 1.000 rs73844281 chr4:122664688 A/G cg20573242 chr4:122745356 CCNA2 0.45 6.89 0.35 2.72e-11 Type 2 diabetes; LUSC cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg13010199 chr12:38710504 ALG10B 0.64 9.85 0.47 2.98e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs12618769 0.947 rs72825708 chr2:99239269 C/T cg10123293 chr2:99228465 UNC50 0.42 5.82 0.3 1.35e-8 Bipolar disorder; LUSC cis rs8051149 0.652 rs9926829 chr16:87883089 A/G cg01412419 chr16:87856264 NA -0.39 -5.96 -0.31 6.48e-9 Blood metabolite levels; LUSC cis rs763121 0.815 rs4821799 chr22:39021326 T/G cg06022373 chr22:39101656 GTPBP1 0.75 12.34 0.56 4.27e-29 Menopause (age at onset); LUSC cis rs6835098 1.000 rs9990666 chr4:174083150 G/T cg08422745 chr4:174089978 GALNT7 -0.84 -13.79 -0.6 1.43e-34 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg19077165 chr18:44547161 KATNAL2 0.45 6.75 0.35 6.74e-11 Personality dimensions; LUSC cis rs7615316 0.751 rs6800695 chr3:142044904 G/A cg16271453 chr3:142027066 XRN1 -0.41 -7.17 -0.37 4.74e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7727544 0.582 rs10052046 chr5:131544466 G/T cg14196790 chr5:131705035 SLC22A5 0.42 6.95 0.36 1.88e-11 Blood metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06140764 chr6:30539234 ABCF1 -0.46 -6.97 -0.36 1.71e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg24250549 chr1:154909240 PMVK 0.65 10.87 0.51 9.05e-24 Prostate cancer; LUSC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg20887711 chr4:1340912 KIAA1530 0.55 8.62 0.43 2.79e-16 Longevity; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg02353165 chr6:42928485 GNMT -0.71 -12.36 -0.56 3.78e-29 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9790314 1.000 rs336577 chr3:161066294 C/T cg04691961 chr3:161091175 C3orf57 -0.35 -5.97 -0.31 5.96e-9 Morning vs. evening chronotype; LUSC cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg14019146 chr3:50243930 SLC38A3 0.39 8.57 0.42 3.81e-16 Menarche (age at onset); LUSC cis rs1348850 0.554 rs11679519 chr2:178432110 C/T cg22681709 chr2:178499509 PDE11A -0.39 -5.99 -0.31 5.42e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2806561 0.796 rs1738467 chr1:23506521 C/T cg19743168 chr1:23544995 NA 0.41 8.04 0.4 1.62e-14 Height; LUSC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg18402987 chr7:1209562 NA 0.73 7.85 0.39 5.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16804848 chr11:64052165 GPR137;BAD 0.41 6.12 0.32 2.66e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4253772 0.678 rs9627281 chr22:46644168 A/G cg24881330 chr22:46731750 TRMU 0.69 8.33 0.41 2.12e-15 LDL cholesterol;Cholesterol, total; LUSC cis rs4363385 0.818 rs368912 chr1:153016204 C/G cg00922841 chr1:152955080 SPRR1A -0.45 -7.89 -0.4 4.44e-14 Inflammatory skin disease; LUSC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg13628971 chr7:2884303 GNA12 0.5 7.22 0.37 3.47e-12 Height; LUSC cis rs2853333 1.000 rs2853333 chr19:35747663 C/T cg12287945 chr19:35758300 LSR -0.37 -5.87 -0.31 1.05e-8 Red blood cell count; LUSC cis rs9527 0.590 rs1935323 chr10:104877035 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.74 0.47 6.69e-20 Arsenic metabolism; LUSC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.86 0.31 1.13e-8 Tonsillectomy; LUSC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg09323728 chr8:95962352 TP53INP1 -0.4 -8.62 -0.43 2.78e-16 Type 2 diabetes; LUSC cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg14844989 chr11:31128820 NA -0.37 -5.83 -0.3 1.27e-8 Red blood cell count; LUSC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg12751644 chr20:60527061 NA -0.36 -6.46 -0.33 3.73e-10 Body mass index; LUSC cis rs11997175 0.713 rs4733454 chr8:33651253 C/A ch.8.33884649F chr8:33765107 NA 0.47 7.5 0.38 5.7e-13 Body mass index; LUSC cis rs17604090 0.793 rs17150667 chr7:29689338 G/T cg19413766 chr7:29689036 LOC646762 -0.55 -6.82 -0.35 4.31e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7481584 0.624 rs412149 chr11:3069943 G/A cg05729581 chr11:3078854 CARS 0.39 5.75 0.3 1.97e-8 Calcium levels; LUSC cis rs4363385 0.791 rs4041401 chr1:152985629 A/G cg00922841 chr1:152955080 SPRR1A -0.42 -7.16 -0.36 5.23e-12 Inflammatory skin disease; LUSC cis rs6977660 0.714 rs28371050 chr7:19816882 C/T cg05791153 chr7:19748676 TWISTNB 0.68 7.22 0.37 3.49e-12 Thyroid stimulating hormone; LUSC cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.62 9.14 0.45 6.28e-18 Menarche (age at onset); LUSC cis rs9902453 0.765 rs1531553 chr17:28066752 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.12 -0.52 1.2e-24 Coffee consumption (cups per day); LUSC trans rs208520 0.837 rs208509 chr6:66941706 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.97 -13.62 -0.6 6.51e-34 Exhaled nitric oxide output; LUSC cis rs9309473 0.950 rs11126412 chr2:73887634 A/T cg20560298 chr2:73613845 ALMS1 -0.46 -6.57 -0.34 1.88e-10 Metabolite levels; LUSC cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg00504896 chr12:9437009 LOC642846 -0.48 -7.63 -0.39 2.41e-13 Breast size; LUSC cis rs13385 0.769 rs2337131 chr5:139571288 G/A cg26211634 chr5:139558579 C5orf32 0.44 6.57 0.34 1.96e-10 Atrial fibrillation; LUSC cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg21427119 chr20:30132790 HM13 -0.39 -6.06 -0.31 3.76e-9 Mean corpuscular hemoglobin; LUSC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg19230755 chr7:65878503 NA -0.42 -5.95 -0.31 6.95e-9 Aortic root size; LUSC cis rs1372520 0.935 rs1372519 chr4:90757309 A/G cg15133208 chr4:90757351 SNCA -0.57 -8.74 -0.43 1.12e-16 Neuroticism; LUSC cis rs250677 0.958 rs10056942 chr5:148416114 C/A cg12140854 chr5:148520817 ABLIM3 -0.35 -5.79 -0.3 1.66e-8 Breast cancer; LUSC cis rs1008375 0.797 rs6843530 chr4:17593605 G/T cg16339924 chr4:17578868 LAP3 0.64 10.14 0.49 3.14e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg04398451 chr17:18023971 MYO15A -0.44 -6.93 -0.35 2.19e-11 Total body bone mineral density; LUSC cis rs7824557 0.591 rs2572452 chr8:11228254 C/T cg21293242 chr8:11204541 TDH -0.33 -6.42 -0.33 4.76e-10 Retinal vascular caliber; LUSC cis rs57221529 0.766 rs12519469 chr5:581772 A/G cg09021430 chr5:549028 NA -0.55 -7.28 -0.37 2.47e-12 Lung disease severity in cystic fibrosis; LUSC cis rs9660992 0.967 rs1172135 chr1:205247160 G/C cg00857998 chr1:205179979 DSTYK 0.52 7.78 0.39 9.27e-14 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg22963979 chr7:1858916 MAD1L1 -0.5 -7.36 -0.37 1.42e-12 Schizophrenia; LUSC cis rs2652834 0.851 rs4774475 chr15:63407357 T/C cg05507819 chr15:63340323 TPM1 0.45 5.71 0.3 2.53e-8 HDL cholesterol; LUSC trans rs208520 0.874 rs208481 chr6:66922636 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -14.11 -0.61 8.49e-36 Exhaled nitric oxide output; LUSC cis rs911119 0.954 rs116786204 chr20:23599918 T/G cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC trans rs61931739 0.749 rs11053093 chr12:34231095 A/G cg24313572 chr1:56050060 NA -0.31 -6.63 -0.34 1.35e-10 Morning vs. evening chronotype; LUSC cis rs56399783 0.901 rs73049362 chr7:2826822 G/A cg19731401 chr7:2775893 GNA12 0.69 9.48 0.46 4.97e-19 Childhood ear infection; LUSC cis rs2637266 1.000 rs7900616 chr10:78367075 C/T cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg14004847 chr7:1930337 MAD1L1 0.6 9.45 0.46 6.12e-19 Bipolar disorder and schizophrenia; LUSC cis rs924607 0.898 rs905193 chr5:635095 T/C cg09021430 chr5:549028 NA -0.42 -7.49 -0.38 6.29e-13 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs4443100 0.670 rs9608071 chr22:23408118 G/T cg14186256 chr22:23484241 RTDR1 0.47 6.03 0.31 4.27e-9 Serum parathyroid hormone levels; LUSC cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg03676636 chr4:99064102 C4orf37 -0.37 -8.19 -0.41 5.56e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.29e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12210905 0.844 rs7773336 chr6:26993555 A/G cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.99 -0.31 5.28e-9 Hip circumference adjusted for BMI; LUSC cis rs1595825 0.891 rs16824631 chr2:198708695 T/G cg19156104 chr2:198669113 PLCL1 -0.46 -5.65 -0.3 3.47e-8 Ulcerative colitis; LUSC cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg08470875 chr2:26401718 FAM59B 0.74 9.25 0.45 2.78e-18 Gut microbiome composition (summer); LUSC cis rs9527 0.590 rs7067663 chr10:104883650 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg04352962 chr1:209979756 IRF6 0.52 6.08 0.32 3.28e-9 Cleft lip with or without cleft palate; LUSC cis rs3733585 0.648 rs13125029 chr4:9982029 A/G cg11266682 chr4:10021025 SLC2A9 0.51 9.43 0.46 7.16e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1009647 0.645 rs17672298 chr14:55700284 T/C cg04306507 chr14:55594613 LGALS3 0.45 6.1 0.32 2.99e-9 Testicular germ cell tumor; LUSC cis rs981844 0.712 rs6535956 chr4:154746001 G/A cg14289246 chr4:154710475 SFRP2 -0.44 -6.12 -0.32 2.6e-9 Response to statins (LDL cholesterol change); LUSC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.5 0.53 5.33e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.97 -0.36 1.74e-11 Lung cancer; LUSC cis rs208520 0.690 rs12213581 chr6:66735818 T/C cg07460842 chr6:66804631 NA 1.1 17.27 0.69 3.24e-48 Exhaled nitric oxide output; LUSC cis rs2204008 0.747 rs11514040 chr12:38201040 G/A cg13010199 chr12:38710504 ALG10B 0.71 10.91 0.51 6.53e-24 Bladder cancer; LUSC cis rs4595586 0.545 rs12828790 chr12:39401043 G/A cg13010199 chr12:38710504 ALG10B 0.42 6.08 0.32 3.25e-9 Morning vs. evening chronotype; LUSC cis rs9886651 0.935 rs4733759 chr8:128804840 C/T cg07795030 chr8:128802207 NA -0.34 -6.05 -0.31 3.97e-9 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg06074448 chr4:187884817 NA -0.43 -7.22 -0.37 3.62e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg26314531 chr2:26401878 FAM59B -0.68 -9.23 -0.45 3.18e-18 Gut microbiome composition (summer); LUSC trans rs747782 0.527 rs75915859 chr11:48232931 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.57 0.34 1.95e-10 Intraocular pressure; LUSC cis rs61931739 0.534 rs11053000 chr12:34079022 C/T cg06521331 chr12:34319734 NA -0.47 -7.61 -0.38 2.87e-13 Morning vs. evening chronotype; LUSC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.61e-8 Diabetic kidney disease; LUSC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg26597838 chr10:835615 NA 0.97 13.47 0.59 2.55e-33 Eosinophil percentage of granulocytes; LUSC trans rs1486139 1.000 rs2126443 chr7:46286354 G/A cg17534202 chr9:96721102 NA -0.37 -6.62 -0.34 1.45e-10 Select biomarker traits; LUSC trans rs6600671 1.000 rs12145080 chr1:121185531 C/T cg08727972 chr1:148025634 NBPF14 -0.45 -6.28 -0.32 1.08e-9 Hip geometry; LUSC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg27411982 chr8:10470053 RP1L1 0.4 6.31 0.33 9.08e-10 Myopia (pathological); LUSC cis rs965604 1.000 rs12910910 chr15:78767850 C/T cg18825076 chr15:78729989 IREB2 -0.42 -6.83 -0.35 3.99e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7937682 0.921 rs11213945 chr11:111461003 A/G cg09085632 chr11:111637200 PPP2R1B 0.96 13.81 0.6 1.28e-34 Primary sclerosing cholangitis; LUSC cis rs6570726 1.000 rs6570699 chr6:145920732 G/A cg05347473 chr6:146136440 FBXO30 0.41 6.63 0.34 1.38e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.2 -0.41 5.4e-15 Longevity; LUSC cis rs6964587 0.869 rs7778667 chr7:91520816 C/G cg17063962 chr7:91808500 NA -0.53 -8.24 -0.41 4.03e-15 Breast cancer; LUSC trans rs7618501 0.602 rs34831713 chr3:50118748 T/C cg21659725 chr3:3221576 CRBN -0.63 -10.33 -0.49 6.89e-22 Intelligence (multi-trait analysis); LUSC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg17211192 chr8:82754475 SNX16 0.62 8.82 0.43 6.25e-17 Diastolic blood pressure; LUSC cis rs4319547 0.955 rs6489159 chr12:123112806 G/A cg23029597 chr12:123009494 RSRC2 -0.73 -9.26 -0.45 2.61e-18 Body mass index; LUSC cis rs1185460 0.547 rs34150933 chr11:118911039 C/T cg01677386 chr11:118938358 VPS11 0.46 6.66 0.34 1.12e-10 Coronary artery disease; LUSC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg01475377 chr6:109611718 NA -0.45 -8.11 -0.41 9.58e-15 Reticulocyte fraction of red cells; LUSC cis rs62229266 0.626 rs2835268 chr21:37449136 C/G cg12218747 chr21:37451666 NA -0.43 -6.59 -0.34 1.71e-10 Mitral valve prolapse; LUSC cis rs796364 0.760 rs55906940 chr2:201049386 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -7.61 -0.38 2.74e-13 Schizophrenia; LUSC trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg03929089 chr4:120376271 NA 0.68 7.58 0.38 3.49e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs2115536 0.730 rs4238512 chr15:80183898 A/C cg02196730 chr15:80188777 MTHFS -0.38 -5.75 -0.3 2.05e-8 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs56235845 0.665 rs4976685 chr5:176766177 C/T cg06060754 chr5:176797920 RGS14 -0.59 -9.32 -0.45 1.61e-18 Hemoglobin concentration;Hematocrit; LUSC cis rs6577655 0.517 rs6998749 chr8:135584316 A/G cg17885191 chr8:135476712 NA -0.6 -7.79 -0.39 8.73e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg00321850 chr1:175162397 KIAA0040 -0.45 -7.76 -0.39 1.05e-13 Alcohol dependence; LUSC cis rs9300255 0.739 rs10846491 chr12:123753492 C/G cg05973401 chr12:123451056 ABCB9 0.55 6.8 0.35 4.9e-11 Neutrophil percentage of white cells; LUSC cis rs1322512 0.713 rs1631241 chr6:152939860 T/C cg27316956 chr6:152958899 SYNE1 -0.35 -5.8 -0.3 1.58e-8 Tonometry; LUSC cis rs2548003 0.541 rs1160444 chr5:28763652 G/A cg22863700 chr5:28928346 NA 0.45 6.31 0.33 8.68e-10 Hip geometry; LUSC trans rs8072100 0.817 rs12449647 chr17:45548958 C/A cg03886242 chr7:26192032 NFE2L3 -0.42 -6.69 -0.34 9.24e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2742417 0.967 rs2742439 chr3:45744248 G/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.5 -0.38 5.91e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2115536 0.967 rs934137 chr15:80211768 T/C cg00225070 chr15:80189496 MTHFS 0.63 9.49 0.46 4.54e-19 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7829975 0.755 rs3789849 chr8:8687054 G/C cg06636001 chr8:8085503 FLJ10661 0.6 9.36 0.46 1.19e-18 Mood instability; LUSC cis rs73206853 0.841 rs17187412 chr12:110766767 C/T cg12870014 chr12:110450643 ANKRD13A -0.69 -6.32 -0.33 8.47e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs868036 0.681 rs4776981 chr15:68109474 G/A cg05925327 chr15:68127851 NA -0.4 -6.4 -0.33 5.35e-10 Restless legs syndrome; LUSC trans rs7944735 0.517 rs12274550 chr11:48196752 C/A cg03929089 chr4:120376271 NA 0.68 6.39 0.33 5.54e-10 Intraocular pressure; LUSC cis rs7131987 0.650 rs10843382 chr12:29451721 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.55 -0.34 2.21e-10 QT interval; LUSC trans rs2262909 0.962 rs73021832 chr19:22316144 G/C cg05197062 chr11:11642011 GALNTL4 0.55 7.76 0.39 1.03e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs72799341 1.000 rs35675346 chr16:30936081 G/A cg02466173 chr16:30829666 NA -0.5 -7.7 -0.39 1.55e-13 Diastolic blood pressure; LUSC cis rs977987 0.624 rs59867374 chr16:75432682 G/A cg03315344 chr16:75512273 CHST6 0.48 8.93 0.44 2.98e-17 Dupuytren's disease; LUSC cis rs6598955 0.543 rs6699798 chr1:26556442 G/T cg04990556 chr1:26633338 UBXN11 0.88 11.59 0.54 2.55e-26 Obesity-related traits; LUSC cis rs17270561 0.609 rs9356986 chr6:25739119 T/C cg16482183 chr6:26056742 HIST1H1C 0.63 8.96 0.44 2.34e-17 Iron status biomarkers; LUSC cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg04362960 chr10:104952993 NT5C2 0.61 9.77 0.47 5.38e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1355223 0.506 rs11032899 chr11:34870234 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.71 -0.34 8.49e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg07701084 chr6:150067640 NUP43 0.53 7.82 0.39 7.22e-14 Lung cancer; LUSC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.94 0.48 1.47e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs892085 0.681 rs10417071 chr19:10872431 G/T cg17710535 chr19:10819994 QTRT1 0.34 5.66 0.3 3.21e-8 Psoriasis vulgaris;Psoriasis; LUSC cis rs9948 0.529 rs62156222 chr2:97410988 C/A cg01990225 chr2:97406019 LMAN2L -1.08 -7.25 -0.37 3.01e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs1577917 0.876 rs4618490 chr6:86518403 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.63 -0.34 1.37e-10 Response to antipsychotic treatment; LUSC cis rs7267979 0.932 rs367666 chr20:25449818 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.06 0.74 2.65e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.44 -0.42 9.51e-16 Cystic fibrosis severity; LUSC cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg07148914 chr20:33460835 GGT7 -0.55 -8.46 -0.42 8.69e-16 Glomerular filtration rate (creatinine); LUSC cis rs477692 0.569 rs871028 chr10:131293478 C/T cg26102564 chr10:131424627 MGMT -0.35 -5.68 -0.3 2.9e-8 Response to temozolomide; LUSC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg11812906 chr14:75593930 NEK9 -0.62 -10.45 -0.5 2.6e-22 Height; LUSC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg10207240 chr12:122356781 WDR66 0.48 6.81 0.35 4.6e-11 Mean corpuscular volume; LUSC cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg15839431 chr19:19639596 YJEFN3 -0.6 -6.87 -0.35 3.14e-11 Bipolar disorder; LUSC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg12863693 chr15:85201151 NMB -0.26 -5.92 -0.31 7.9e-9 P wave terminal force; LUSC cis rs714027 0.546 rs5997549 chr22:30265344 C/T cg11564601 chr22:30592435 NA 0.33 5.83 0.3 1.33e-8 Lymphocyte counts; LUSC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.92 0.31 8e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.55 -9.99 -0.48 1e-20 Bipolar disorder; LUSC cis rs11785693 0.865 rs7815144 chr8:4970788 G/T cg26367366 chr8:4980734 NA -0.74 -9.21 -0.45 3.74e-18 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7582720 1.000 rs114395475 chr2:203769112 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.66 0.43 2.06e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg01879757 chr17:41196368 BRCA1 -0.47 -7.07 -0.36 8.95e-12 Menopause (age at onset); LUSC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg12615879 chr12:58013172 SLC26A10 -0.28 -5.83 -0.3 1.32e-8 Multiple sclerosis; LUSC cis rs9325144 0.577 rs12314639 chr12:39119869 T/C cg26384229 chr12:38710491 ALG10B -0.59 -9.33 -0.45 1.55e-18 Morning vs. evening chronotype; LUSC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg02569458 chr12:86230093 RASSF9 0.58 9.93 0.48 1.56e-20 Major depressive disorder; LUSC cis rs7208859 0.623 rs9896603 chr17:29078512 C/G cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1865760 0.566 rs9295688 chr6:26084217 G/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg18404041 chr3:52824283 ITIH1 0.4 6.78 0.35 5.59e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg13628971 chr7:2884303 GNA12 0.37 5.71 0.3 2.53e-8 Height; LUSC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg08270630 chr22:50330655 NA 0.41 6.05 0.31 3.86e-9 Schizophrenia; LUSC cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg22676075 chr6:135203613 NA 0.59 9.48 0.46 5e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg13939156 chr17:80058883 NA -0.34 -6.76 -0.35 6.08e-11 Life satisfaction; LUSC cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg20701182 chr2:24300061 SF3B14 0.89 11.69 0.54 1.08e-26 Lymphocyte counts; LUSC cis rs317689 0.690 rs607797 chr12:69646010 T/C cg11871910 chr12:69753446 YEATS4 0.44 5.78 0.3 1.74e-8 Response to diuretic therapy; LUSC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg24920358 chr1:40204285 PPIE 0.6 10.8 0.51 1.64e-23 Blood protein levels; LUSC cis rs11048434 0.736 rs2041625 chr12:9112005 C/T cg23795048 chr12:9217529 LOC144571 0.34 6.01 0.31 4.82e-9 Sjögren's syndrome; LUSC cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg25427524 chr10:38739819 LOC399744 -0.58 -10.26 -0.49 1.17e-21 Extrinsic epigenetic age acceleration; LUSC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg24675658 chr1:53192096 ZYG11B 0.72 11.91 0.55 1.75e-27 Monocyte count; LUSC cis rs7824557 0.603 rs11250130 chr8:11214455 C/T cg21775007 chr8:11205619 TDH -0.73 -11.66 -0.54 1.43e-26 Retinal vascular caliber; LUSC cis rs9837602 1.000 rs9833980 chr3:99767096 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.89 -0.31 9.61e-9 Breast cancer; LUSC trans rs225245 0.791 rs7406966 chr17:34013636 A/C cg19694781 chr19:47549865 TMEM160 -0.4 -6.25 -0.32 1.24e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs2109514 1.000 rs3919515 chr7:116151784 C/G cg12739419 chr7:116140593 CAV2 0.31 6.99 0.36 1.53e-11 Prevalent atrial fibrillation; LUSC cis rs6494488 0.500 rs7173216 chr15:65023156 C/T cg08069370 chr15:64387884 SNX1 -0.58 -5.66 -0.3 3.23e-8 Coronary artery disease; LUSC cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg05707623 chr12:122985044 ZCCHC8 -0.66 -8.65 -0.43 2.2e-16 Body mass index; LUSC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg15557168 chr22:42548783 NA 0.46 7.01 0.36 1.35e-11 Schizophrenia; LUSC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg12564285 chr5:131593104 PDLIM4 0.32 5.68 0.3 3.01e-8 Breast cancer;Mosquito bite size; LUSC cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs9640161 0.658 rs60467296 chr7:150015471 G/A cg10018233 chr7:150070692 REPIN1 0.34 5.97 0.31 6.05e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs8072100 0.967 rs4793842 chr17:45671506 G/A cg04995722 chr7:26192034 NFE2L3 0.37 6.15 0.32 2.24e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2692947 0.800 rs2692936 chr2:96745729 G/A cg23100626 chr2:96804247 ASTL 0.3 7.05 0.36 1.02e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1577917 0.771 rs2475791 chr6:86368164 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.94 -0.51 5.25e-24 Response to antipsychotic treatment; LUSC cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg01579765 chr21:45077557 HSF2BP -0.47 -9.81 -0.47 3.94e-20 Mean corpuscular volume; LUSC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg23422044 chr7:1970798 MAD1L1 -0.6 -6.27 -0.32 1.13e-9 Bipolar disorder; LUSC cis rs2294693 0.634 rs4714425 chr6:41012916 A/G cg14769373 chr6:40998127 UNC5CL 0.42 5.96 0.31 6.55e-9 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs11625487 1.000 rs11625487 chr14:77961609 G/C cg21822146 chr14:77961897 ISM2 -0.33 -5.78 -0.3 1.72e-8 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg05855489 chr10:104503620 C10orf26 0.53 7.73 0.39 1.25e-13 Arsenic metabolism; LUSC cis rs7312933 0.558 rs1669936 chr12:42813509 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.83 -0.35 4.12e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs12410462 0.581 rs7541809 chr1:227547299 G/A cg10327440 chr1:227177885 CDC42BPA -0.67 -6.41 -0.33 4.99e-10 Major depressive disorder; LUSC cis rs7191439 0.858 rs8044367 chr16:88783374 A/G cg26217441 chr16:89643414 CPNE7 -0.52 -5.66 -0.3 3.33e-8 Plateletcrit; LUSC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg22508957 chr16:3507546 NAT15 0.48 6.46 0.33 3.69e-10 Body mass index (adult); LUSC cis rs66887589 0.934 rs7672519 chr4:120544112 C/T cg09307838 chr4:120376055 NA -0.49 -7.48 -0.38 6.79e-13 Diastolic blood pressure; LUSC cis rs72949976 0.934 rs1441172 chr2:214037703 C/T cg08319019 chr2:214017104 IKZF2 -0.58 -8.92 -0.44 3.09e-17 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs778371 0.748 rs2675953 chr2:233749565 G/C cg08000102 chr2:233561755 GIGYF2 -0.75 -11.24 -0.52 4.38e-25 Schizophrenia; LUSC cis rs2455601 0.608 rs16906256 chr11:8887097 A/G cg12365402 chr11:9010492 NRIP3 -0.36 -5.87 -0.31 1.05e-8 Schizophrenia; LUSC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.64 0.6 5.37e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg03395511 chr6:291903 DUSP22 -0.48 -7.28 -0.37 2.42e-12 Menopause (age at onset); LUSC cis rs10203711 0.966 rs907105 chr2:239565052 A/G cg14580085 chr2:239553406 NA 0.42 7.15 0.36 5.57e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7605827 0.897 rs7590198 chr2:15536314 C/T cg19274914 chr2:15703543 NA 0.46 9.03 0.44 1.45e-17 Educational attainment (years of education); LUSC trans rs7824557 0.767 rs1897950 chr8:11169551 C/A cg06636001 chr8:8085503 FLJ10661 0.53 7.9 0.4 3.97e-14 Retinal vascular caliber; LUSC trans rs35110281 0.627 rs56369437 chr21:44970275 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.89 0.48 2.13e-20 Mean corpuscular volume; LUSC cis rs7824557 0.564 rs2572395 chr8:11235360 A/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.0 -0.31 5.16e-9 Retinal vascular caliber; LUSC cis rs6961069 0.585 rs10247260 chr7:80255763 A/T cg04458919 chr7:80252533 CD36 -0.4 -7.1 -0.36 7.4e-12 Platelet count; LUSC cis rs7617480 0.648 rs6766238 chr3:48801929 G/A cg21141812 chr3:48556323 PFKFB4 0.33 5.73 0.3 2.2e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg03579872 chr1:53393473 SCP2 -0.4 -5.87 -0.31 1.07e-8 Monocyte count; LUSC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.78 9.14 0.45 6.39e-18 Mean platelet volume; LUSC trans rs941408 0.515 rs12610096 chr19:2778129 C/T cg22153745 chr1:153894579 GATAD2B -0.5 -6.89 -0.35 2.84e-11 Total cholesterol levels; LUSC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg05340658 chr4:99064831 C4orf37 0.68 11.53 0.53 4.19e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9388451 0.807 rs1269175 chr6:126040435 A/G cg10911889 chr6:126070802 HEY2 -0.38 -5.91 -0.31 8.41e-9 Brugada syndrome; LUSC cis rs7107174 0.901 rs1055250 chr11:77925708 C/G cg02023728 chr11:77925099 USP35 0.5 7.17 0.37 4.75e-12 Testicular germ cell tumor; LUSC cis rs9467711 0.591 rs116201501 chr6:25999149 C/T cg16898833 chr6:26189333 HIST1H4D 0.64 6.14 0.32 2.39e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs11955175 1.000 rs77394428 chr5:40743517 A/G cg04002187 chr5:40835754 RPL37 0.69 5.79 0.3 1.66e-8 Bipolar disorder and schizophrenia; LUSC cis rs1005224 0.963 rs11626062 chr14:76136329 T/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.63 -8.64 -0.43 2.42e-16 Large artery stroke; LUSC cis rs2797160 0.547 rs9401837 chr6:125956853 T/C cg05901451 chr6:126070800 HEY2 -0.42 -5.91 -0.31 8.39e-9 Endometrial cancer; LUSC cis rs11098499 0.599 rs3864142 chr4:120266191 A/T cg24375607 chr4:120327624 NA 0.69 10.92 0.51 6.06e-24 Corneal astigmatism; LUSC cis rs2301436 0.512 rs6925969 chr6:167501738 C/A cg06454157 chr6:167490870 NA -0.27 -6.13 -0.32 2.48e-9 Crohn's disease; LUSC cis rs3771570 0.901 rs35256094 chr2:242439938 A/C cg21155796 chr2:242212141 HDLBP 0.62 6.8 0.35 4.74e-11 Prostate cancer; LUSC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg24562669 chr7:97807699 LMTK2 -0.35 -6.23 -0.32 1.38e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg02175503 chr12:58329896 NA 0.62 10.21 0.49 1.81e-21 Intelligence (multi-trait analysis); LUSC cis rs17604090 0.938 rs850029 chr7:29678087 A/G cg19413766 chr7:29689036 LOC646762 -0.55 -6.42 -0.33 4.71e-10 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7100689 0.646 rs2039757 chr10:82078868 C/A cg00277334 chr10:82204260 NA -0.58 -8.73 -0.43 1.25e-16 Post bronchodilator FEV1; LUSC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg11584989 chr19:19387371 SF4 0.58 6.85 0.35 3.58e-11 Bipolar disorder; LUSC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.79 -0.54 4.53e-27 Chronic sinus infection; LUSC cis rs62400317 0.859 rs11967630 chr6:45128524 G/C cg20913747 chr6:44695427 NA -0.46 -7.49 -0.38 6.22e-13 Total body bone mineral density; LUSC cis rs7804356 0.953 rs3823928 chr7:26893317 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.13 -0.32 2.54e-9 Type 1 diabetes; LUSC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg16624210 chr5:671434 TPPP 0.47 5.92 0.31 8.21e-9 Lung disease severity in cystic fibrosis; LUSC cis rs847851 0.630 rs9462021 chr6:34758640 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.02 -0.31 4.55e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7953249 0.656 rs1732391 chr12:121392341 C/T cg25281562 chr12:121454272 C12orf43 -0.43 -5.76 -0.3 1.9e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs4842666 0.915 rs11105354 chr12:90026523 A/G cg00757033 chr12:89920650 WDR51B 0.48 6.39 0.33 5.49e-10 Blood pressure; LUSC cis rs9341808 0.556 rs1535075 chr6:81034806 A/G cg08355045 chr6:80787529 NA 0.51 8.85 0.44 5.25e-17 Sitting height ratio; LUSC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg17971929 chr21:40555470 PSMG1 -0.5 -7.35 -0.37 1.57e-12 Menarche (age at onset); LUSC cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 27.87 0.84 3.57e-89 Chronic sinus infection; LUSC cis rs8099014 0.814 rs7227488 chr18:56113233 A/G cg12907477 chr18:56117327 MIR122 0.45 7.04 0.36 1.12e-11 Platelet count; LUSC cis rs17095355 1.000 rs12263484 chr10:111697255 A/G cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.83 -0.39 6.72e-14 Biliary atresia; LUSC cis rs681343 0.746 rs633372 chr19:49209226 G/A cg21064579 chr19:49206444 FUT2 0.46 8.66 0.43 2.07e-16 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; LUSC cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.67 -10.59 -0.5 8.96e-23 Body mass index (adult); LUSC cis rs3812762 1.000 rs3812762 chr11:8751640 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.36 -6.03 -0.31 4.31e-9 Hypospadias; LUSC cis rs3768617 0.510 rs4651143 chr1:183097398 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 10.95 0.51 4.95e-24 Fuchs's corneal dystrophy; LUSC cis rs4363385 0.588 rs11205180 chr1:153022070 A/G cg00922841 chr1:152955080 SPRR1A -0.37 -6.3 -0.33 9.57e-10 Inflammatory skin disease; LUSC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg15147215 chr3:52552868 STAB1 0.31 6.14 0.32 2.4e-9 Electroencephalogram traits; LUSC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg03233332 chr7:66118400 NA -0.39 -5.73 -0.3 2.23e-8 Aortic root size; LUSC cis rs2404618 0.504 rs2906567 chr8:1494118 C/T cg02903104 chr8:1507517 DLGAP2 0.4 7.56 0.38 3.99e-13 Lung cancer; LUSC cis rs10876993 0.928 rs2169988 chr12:58071165 G/A cg18357645 chr12:58087776 OS9 0.55 8.23 0.41 4.17e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs1524927 0.966 rs55837946 chr7:96330682 C/T cg03808172 chr7:96339361 SHFM1 0.43 6.63 0.34 1.34e-10 Total body bone mineral density; LUSC cis rs4654899 0.758 rs6698462 chr1:21341293 G/C cg01072550 chr1:21505969 NA -0.53 -8.16 -0.41 7.06e-15 Superior frontal gyrus grey matter volume; LUSC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg02423579 chr7:2872169 GNA12 -0.45 -6.76 -0.35 6.23e-11 Height; LUSC cis rs7131987 0.903 rs10843367 chr12:29408380 G/A cg09582351 chr12:29534625 ERGIC2 -0.34 -6.91 -0.35 2.44e-11 QT interval; LUSC cis rs68170813 0.523 rs79619227 chr7:107025335 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.3 -0.45 1.88e-18 Coronary artery disease; LUSC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg16339924 chr4:17578868 LAP3 0.65 10.05 0.48 6.41e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg16423285 chr20:60520624 NA -0.47 -5.75 -0.3 2.06e-8 Body mass index; LUSC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg26727032 chr16:67993705 SLC12A4 -0.44 -5.9 -0.31 8.7e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg01073479 chr16:3509474 NAT15 -0.39 -5.97 -0.31 5.96e-9 Tuberculosis; LUSC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg13114125 chr14:105738426 BRF1 -0.91 -15.83 -0.65 1.68e-42 Mean platelet volume;Platelet distribution width; LUSC trans rs12310956 0.532 rs10506119 chr12:33963684 A/G cg13010199 chr12:38710504 ALG10B 0.57 8.51 0.42 6.15e-16 Morning vs. evening chronotype; LUSC cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg16339924 chr4:17578868 LAP3 -0.51 -7.52 -0.38 4.97e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs701145 0.585 rs959376 chr3:153866707 A/T cg17054900 chr3:154042577 DHX36 0.63 6.18 0.32 1.9e-9 Coronary artery disease; LUSC cis rs7804356 1.000 rs10486485 chr7:26900356 C/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.1 -0.32 2.9e-9 Type 1 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg21039410 chr2:26568409 SELI;GPR113 -0.52 -6.94 -0.36 2.06e-11 Hepatitis; LUSC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg03678062 chr6:149772716 ZC3H12D -0.37 -7.49 -0.38 6.32e-13 Dupuytren's disease; LUSC cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg04998671 chr14:104000505 TRMT61A -0.42 -5.91 -0.31 8.58e-9 Reticulocyte count; LUSC cis rs2070488 0.775 rs762318 chr3:38516369 C/A cg24069376 chr3:38537580 EXOG 0.42 8.17 0.41 6.5e-15 Electrocardiographic conduction measures; LUSC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.63 0.5 6.32e-23 Schizophrenia; LUSC cis rs9814567 1.000 rs35718987 chr3:134272783 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg07936489 chr17:37558343 FBXL20 -0.71 -9.96 -0.48 1.21e-20 Glomerular filtration rate (creatinine); LUSC cis rs7945718 0.839 rs11022511 chr11:12834638 A/T cg25843174 chr11:12811716 TEAD1 0.3 6.77 0.35 5.83e-11 Educational attainment (years of education); LUSC cis rs1476679 1.000 rs1476679 chr7:100004446 C/T cg19116668 chr7:99932089 PMS2L1 0.45 8.08 0.4 1.17e-14 Alzheimer's disease (late onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18009825 chr17:62503196 CCDC45;DDX5 -0.45 -6.64 -0.34 1.25e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9291683 0.595 rs11722930 chr4:10035454 G/A cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.01e-12 Bone mineral density; LUSC cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -7.47 -0.38 7.17e-13 Chronic sinus infection; LUSC cis rs9837602 1.000 rs1038294 chr3:99503728 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -5.73 -0.3 2.26e-8 Breast cancer; LUSC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg08125733 chr17:73851984 WBP2 -0.45 -6.42 -0.33 4.56e-10 White matter hyperintensity burden; LUSC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg05623727 chr3:50126028 RBM5 0.31 5.73 0.3 2.2e-8 Intelligence (multi-trait analysis); LUSC cis rs2760061 0.583 rs708118 chr1:228201801 A/G cg02753203 chr1:228287806 NA -0.89 -17.54 -0.69 2.85e-49 Diastolic blood pressure; LUSC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg07395648 chr5:131743802 NA -0.48 -7.67 -0.39 1.86e-13 Breast cancer;Mosquito bite size; LUSC cis rs9303401 0.527 rs12939313 chr17:56755616 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.85 12.01 0.55 7.54e-28 Cognitive test performance; LUSC cis rs3741151 0.881 rs7951174 chr11:73093135 G/C cg17517138 chr11:73019481 ARHGEF17 0.99 8.39 0.42 1.4e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7084921 0.578 rs12783521 chr10:101871748 C/A cg02250046 chr10:101825185 CPN1 -0.35 -6.24 -0.32 1.34e-9 Bone mineral density; LUSC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg05754148 chr16:3507555 NAT15 0.79 9.49 0.46 4.51e-19 Tuberculosis; LUSC cis rs9611519 0.754 rs4820435 chr22:41652846 G/T cg03806693 chr22:41940476 POLR3H -0.59 -8.58 -0.43 3.58e-16 Neuroticism; LUSC cis rs7085104 0.700 rs3740397 chr10:104592675 G/C cg23093090 chr10:104574429 C10orf26 -0.42 -7.31 -0.37 1.99e-12 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05039488 chr6:79577232 IRAK1BP1 0.64 10.17 0.49 2.35e-21 Endometrial cancer; LUSC cis rs68170813 0.559 rs7981 chr7:106843133 G/C cg02696742 chr7:106810147 HBP1 -0.63 -9.4 -0.46 8.74e-19 Coronary artery disease; LUSC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg21028142 chr17:79581711 NPLOC4 0.33 7.99 0.4 2.22e-14 Eye color traits; LUSC cis rs2625529 0.689 rs12050794 chr15:72169466 G/A cg16672083 chr15:72433130 SENP8 0.47 7.64 0.39 2.31e-13 Red blood cell count; LUSC cis rs6138458 1.000 rs227618 chr20:24909472 T/C cg26195577 chr20:24973756 C20orf3 1.12 18.09 0.7 1.76e-51 Blood protein levels; LUSC cis rs2976388 1.000 rs1045605 chr8:143764101 C/G cg17252645 chr8:143867129 LY6D -0.37 -6.46 -0.33 3.61e-10 Urinary tract infection frequency; LUSC cis rs9905704 0.624 rs6503891 chr17:57065924 A/C cg12560992 chr17:57184187 TRIM37 0.62 9.89 0.48 2.14e-20 Testicular germ cell tumor; LUSC cis rs9796 0.558 rs8043253 chr15:41503730 C/T cg18705301 chr15:41695430 NDUFAF1 -0.52 -9.37 -0.46 1.08e-18 Menopause (age at onset); LUSC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.41 -0.5 3.6e-22 Bipolar disorder; LUSC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg13944838 chr5:179740914 GFPT2 -0.67 -10.74 -0.51 2.58e-23 Height; LUSC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg06238570 chr21:40685208 BRWD1 -0.56 -8.73 -0.43 1.25e-16 Menarche (age at onset); LUSC cis rs748404 0.578 rs576557 chr15:43597737 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.49 6.79 0.35 5.27e-11 Lung cancer; LUSC cis rs8040855 0.627 rs12905036 chr15:85637788 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.39 -5.71 -0.3 2.52e-8 Bulimia nervosa; LUSC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.98 0.55 9.51e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.34 -0.42 1.91e-15 Lung cancer; LUSC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg21699342 chr2:239360505 ASB1 0.56 10.33 0.49 6.86e-22 Multiple system atrophy; LUSC cis rs34638657 0.872 rs7202258 chr16:82195013 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.12 -0.32 2.68e-9 Lung adenocarcinoma; LUSC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18404041 chr3:52824283 ITIH1 -0.53 -10.21 -0.49 1.76e-21 Electroencephalogram traits; LUSC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.53 -5.74 -0.3 2.09e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs3768617 0.811 rs4366285 chr1:183013672 T/G ch.1.3577855R chr1:183094577 LAMC1 0.6 8.59 0.43 3.46e-16 Fuchs's corneal dystrophy; LUSC cis rs9527 0.590 rs3781281 chr10:104852648 A/G cg23093090 chr10:104574429 C10orf26 0.35 6.32 0.33 8.25e-10 Arsenic metabolism; LUSC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg22903657 chr4:1355424 KIAA1530 -0.37 -6.3 -0.33 9.34e-10 Obesity-related traits; LUSC cis rs7771547 0.519 rs6457912 chr6:36373794 C/A cg07856975 chr6:36356162 ETV7 0.44 6.43 0.33 4.32e-10 Platelet distribution width; LUSC cis rs6430585 0.527 rs62168830 chr2:136443900 A/T cg07169764 chr2:136633963 MCM6 1.06 14.11 0.61 8.61e-36 Corneal structure; LUSC cis rs9369695 0.881 rs9349409 chr6:47463126 G/T cg20196966 chr6:47445060 CD2AP 0.42 5.81 0.3 1.49e-8 Reticulocyte count; LUSC cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 3.09e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs67696533 0.600 rs3746615 chr20:31123592 A/T cg13636640 chr20:31349939 DNMT3B 0.46 6.13 0.32 2.51e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2346177 0.875 rs2881327 chr2:46641955 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.57 -8.99 -0.44 1.85e-17 HDL cholesterol; LUSC cis rs4776059 0.798 rs11855616 chr15:52874833 C/T cg24008177 chr15:52972085 KIAA1370 -0.33 -5.66 -0.3 3.22e-8 Schizophrenia; LUSC cis rs7560272 0.723 rs1320374 chr2:73828310 T/C cg20560298 chr2:73613845 ALMS1 0.51 7.84 0.39 6.19e-14 Schizophrenia; LUSC cis rs711244 0.748 rs10193295 chr2:37169049 C/T cg14987922 chr2:37194071 STRN 0.43 6.39 0.33 5.45e-10 Mean platelet volume; LUSC cis rs12136530 0.774 rs4912096 chr1:19775113 T/C cg01832549 chr1:19774989 CAPZB -0.32 -6.05 -0.31 3.97e-9 Lead levels in blood; LUSC cis rs317689 0.690 rs317646 chr12:69657145 A/G cg20891283 chr12:69753455 YEATS4 -0.45 -6.08 -0.32 3.3e-9 Response to diuretic therapy; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18099408 chr3:52552593 STAB1 0.41 7.05 0.36 1.03e-11 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24586432 chr2:238969253 SCLY -0.44 -6.45 -0.33 3.81e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg01704862 chr7:150780657 TMUB1 -0.4 -5.99 -0.31 5.45e-9 Electrocardiographic conduction measures; LUSC cis rs9811920 0.683 rs1718235 chr3:99583484 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.35 -6.91 -0.35 2.4e-11 Axial length; LUSC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg22800045 chr5:56110881 MAP3K1 0.68 8.13 0.41 8.74e-15 Initial pursuit acceleration; LUSC cis rs2439831 1.000 rs2256764 chr15:43735763 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.79 7.69 0.39 1.67e-13 Lung cancer in ever smokers; LUSC cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg26587870 chr6:27730563 NA -0.61 -5.79 -0.3 1.62e-8 Breast cancer; LUSC cis rs763121 0.853 rs10135 chr22:39082174 C/T cg06022373 chr22:39101656 GTPBP1 -0.83 -14.16 -0.61 5.55e-36 Menopause (age at onset); LUSC cis rs9837602 1.000 rs6806178 chr3:99780393 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 5.67 0.3 3.16e-8 Breast cancer; LUSC cis rs7917772 0.582 rs10786683 chr10:104320476 G/A cg22532475 chr10:104410764 TRIM8 -0.26 -6.07 -0.32 3.42e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9653442 0.675 rs1115910 chr2:100647872 A/G cg22139774 chr2:100720529 AFF3 -0.45 -7.75 -0.39 1.15e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7809950 0.678 rs7777950 chr7:107004672 T/C cg23024343 chr7:107201750 COG5 -0.66 -9.88 -0.48 2.37e-20 Coronary artery disease; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.5 -8.33 -0.41 2.1e-15 Lymphocyte counts; LUSC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.8 0.35 4.77e-11 Lung cancer; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg24642844 chr7:1081250 C7orf50 -0.8 -10.56 -0.5 1.12e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg14092988 chr3:52407081 DNAH1 0.32 6.25 0.32 1.27e-9 Bipolar disorder; LUSC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg16434002 chr17:42200994 HDAC5 0.47 6.52 0.34 2.56e-10 Total body bone mineral density; LUSC cis rs56399783 0.614 rs11765492 chr7:2771642 G/A cg19731401 chr7:2775893 GNA12 0.73 8.86 0.44 4.67e-17 Childhood ear infection; LUSC cis rs950776 0.531 rs12915652 chr15:78831928 G/A cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs12791968 0.527 rs4755924 chr11:45013328 A/G cg11846598 chr11:44996168 LOC221122 -0.59 -7.12 -0.36 6.77e-12 Inhibitory control; LUSC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.67 -0.34 1.04e-10 Lung cancer; LUSC cis rs11122272 0.735 rs2011357 chr1:231480208 A/G cg06096015 chr1:231504339 EGLN1 0.57 9.97 0.48 1.16e-20 Hemoglobin concentration; LUSC trans rs8030485 0.545 rs939662 chr15:79428249 A/T cg16586880 chr8:140854244 TRAPPC9 -0.37 -6.07 -0.32 3.56e-9 Left ventricle wall thickness; LUSC cis rs2797160 1.000 rs2747724 chr6:126004935 G/A cg05901451 chr6:126070800 HEY2 -0.58 -8.59 -0.43 3.43e-16 Endometrial cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14933266 chr17:29422051 NF1 0.45 5.99 0.31 5.38e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9942416 0.503 rs253393 chr5:74929647 G/A cg06933384 chr5:74808293 COL4A3BP;POLK -0.41 -5.8 -0.3 1.55e-8 Age-related disease endophenotypes; LUSC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.88 -0.31 9.73e-9 Extrinsic epigenetic age acceleration; LUSC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg17971929 chr21:40555470 PSMG1 -0.47 -6.93 -0.35 2.15e-11 Menarche (age at onset); LUSC cis rs7258465 1.000 rs76194 chr19:18630580 T/G cg11102782 chr19:18549136 ISYNA1 -0.32 -6.05 -0.31 3.93e-9 Breast cancer; LUSC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg04478727 chr12:58166393 METTL1;FAM119B 0.49 6.22 0.32 1.48e-9 Multiple sclerosis; LUSC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg24110177 chr3:50126178 RBM5 0.55 9.1 0.45 8.06e-18 Intelligence (multi-trait analysis); LUSC cis rs9910055 1.000 rs9910055 chr17:42283037 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.43 5.82 0.3 1.37e-8 Total body bone mineral density; LUSC cis rs9790314 0.846 rs9809522 chr3:160983768 G/C cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 4.11e-20 Morning vs. evening chronotype; LUSC trans rs10506458 0.915 rs12424908 chr12:63402364 G/A cg22491629 chr6:157744540 C6orf35 -0.89 -10.93 -0.51 5.63e-24 Hemostatic factors and hematological phenotypes; LUSC cis rs1044826 0.957 rs12494556 chr3:139223719 T/C cg00490450 chr3:139108681 COPB2 0.51 6.8 0.35 4.8e-11 Obesity-related traits; LUSC cis rs7193541 0.662 rs8063458 chr16:74469121 G/T cg01733217 chr16:74700730 RFWD3 -0.75 -11.76 -0.54 6.08e-27 Multiple myeloma; LUSC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg13683864 chr3:40499215 RPL14 -1.14 -20.68 -0.75 9.18e-62 Renal cell carcinoma; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg07157834 chr1:205819609 PM20D1 0.85 15.62 0.65 1.11e-41 Menarche (age at onset); LUSC trans rs7765175 0.598 rs1388219 chr6:113620699 C/T cg14711201 chr5:36152436 SKP2;LMBRD2 -0.35 -5.95 -0.31 6.61e-9 Coronary artery calcification; LUSC trans rs61931739 0.534 rs12372557 chr12:34363843 C/T cg26384229 chr12:38710491 ALG10B 0.88 15.09 0.64 1.36e-39 Morning vs. evening chronotype; LUSC trans rs561341 1.000 rs8069199 chr17:30281845 A/G cg20587970 chr11:113659929 NA -1.11 -15.3 -0.64 1.99e-40 Hip circumference adjusted for BMI; LUSC trans rs2055729 0.677 rs10104353 chr8:9740358 G/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.37 -0.33 6.24e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs17253792 0.822 rs80085988 chr14:56096173 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs1003719 0.715 rs8129942 chr21:38552070 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.48 -0.5 2.16e-22 Eye color traits; LUSC cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.52 -0.42 5.75e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7923609 0.967 rs10761762 chr10:65184717 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs765787 0.530 rs4775835 chr15:45537553 T/C cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg12527909 chr1:109241986 PRPF38B -0.37 -6.24 -0.32 1.34e-9 N-glycan levels; LUSC cis rs9359856 0.529 rs72919922 chr6:90492997 G/A cg13799429 chr6:90582589 CASP8AP2 -0.85 -8.24 -0.41 3.84e-15 Bipolar disorder; LUSC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg14664628 chr15:75095509 CSK -0.41 -5.84 -0.3 1.27e-8 Caffeine consumption; LUSC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 13.62 0.6 6.6e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9341808 0.600 rs2505930 chr6:80837058 A/G cg08355045 chr6:80787529 NA 0.48 8.23 0.41 4.2e-15 Sitting height ratio; LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg01125463 chr6:42946178 PEX6 -0.35 -5.65 -0.3 3.35e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg09034736 chr1:150693464 HORMAD1 0.43 5.93 0.31 7.46e-9 Melanoma; LUSC cis rs77741769 0.571 rs12831094 chr12:121292704 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.49 0.42 6.64e-16 Mean corpuscular volume; LUSC trans rs8072100 0.840 rs9912311 chr17:45547132 T/C cg04995722 chr7:26192034 NFE2L3 -0.39 -6.22 -0.32 1.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs897080 0.515 rs1145519 chr2:44708709 C/A cg00619915 chr2:44497795 NA -0.42 -6.06 -0.31 3.6e-9 Height; LUSC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg05805236 chr11:65401703 PCNXL3 -0.38 -5.81 -0.3 1.48e-8 Breast cancer; LUSC cis rs6121246 0.909 rs8126355 chr20:30332660 C/T cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg00012203 chr2:219082015 ARPC2 -0.7 -11.58 -0.54 2.78e-26 Colorectal cancer; LUSC cis rs6594499 0.872 rs6865932 chr5:110436852 G/C cg04022379 chr5:110408740 TSLP 0.45 6.82 0.35 4.17e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg20295408 chr7:1910781 MAD1L1 -0.45 -6.31 -0.33 8.95e-10 Bipolar disorder and schizophrenia; LUSC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg00310523 chr12:86230176 RASSF9 0.45 8.34 0.42 2.01e-15 Major depressive disorder; LUSC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.99 0.4 2.22e-14 Bipolar disorder; LUSC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11890956 chr21:40555474 PSMG1 -0.73 -11.33 -0.53 2.15e-25 Menarche (age at onset); LUSC cis rs6815814 0.950 rs114719937 chr4:38808585 G/C cg02016764 chr4:38805732 TLR1 -0.54 -5.92 -0.31 7.93e-9 Breast cancer; LUSC cis rs2262909 0.962 rs17459246 chr19:22278121 T/C cg11619707 chr19:22235551 ZNF257 0.39 5.79 0.3 1.63e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg07157834 chr1:205819609 PM20D1 0.97 19.5 0.73 4.43e-57 Menarche (age at onset); LUSC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg06618935 chr21:46677482 NA -0.4 -7.99 -0.4 2.2e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1045529 0.524 rs34251783 chr8:8891376 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.66 -0.39 2.07e-13 Myopia;Myopia (pathological); LUSC cis rs1775715 0.737 rs1541260 chr10:32105570 C/T cg03015672 chr10:32216066 ARHGAP12 0.33 5.84 0.3 1.22e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6542838 0.646 rs2008648 chr2:99408323 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.75 -0.35 6.74e-11 Fear of minor pain; LUSC cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg26384229 chr12:38710491 ALG10B -0.84 -15.97 -0.66 4.77e-43 Heart rate; LUSC trans rs11098499 0.863 rs6835635 chr4:120458867 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.49 0.33 3.18e-10 Corneal astigmatism; LUSC cis rs59104589 0.617 rs6672 chr2:242293021 A/G cg14842376 chr2:242211374 HDLBP 0.54 6.16 0.32 2.05e-9 Fibrinogen levels; LUSC cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.78 0.6 1.67e-34 Chronic sinus infection; LUSC cis rs67478160 0.654 rs4906365 chr14:104229230 G/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.16 0.49 2.57e-21 Schizophrenia; LUSC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg06363034 chr20:62225388 GMEB2 -0.45 -7.71 -0.39 1.47e-13 Glioblastoma; LUSC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg09367891 chr1:107599246 PRMT6 -0.52 -8.25 -0.41 3.72e-15 Facial morphology (factor 21, depth of nasal alae); LUSC trans rs1493916 0.967 rs1389532 chr18:31392323 C/T cg13755796 chr4:20253514 NA -0.43 -6.67 -0.34 1.07e-10 Life satisfaction; LUSC cis rs9807989 0.507 rs1833174 chr2:103034843 T/A cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC cis rs4443100 0.670 rs8139280 chr22:23405957 G/A cg14186256 chr22:23484241 RTDR1 0.54 6.83 0.35 4.03e-11 Serum parathyroid hormone levels; LUSC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg09904177 chr6:26538194 HMGN4 -0.39 -5.71 -0.3 2.52e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs9300255 0.602 rs1727316 chr12:123618603 C/T cg00376283 chr12:123451042 ABCB9 0.68 8.56 0.42 4.23e-16 Neutrophil percentage of white cells; LUSC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.39 -5.66 -0.3 3.21e-8 Tonsillectomy; LUSC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg03806693 chr22:41940476 POLR3H -1.06 -15.42 -0.64 6.98e-41 Vitiligo; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg04267008 chr7:1944627 MAD1L1 -0.66 -9.95 -0.48 1.34e-20 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.78 0.43 8.88e-17 Motion sickness; LUSC cis rs6500395 1.000 rs1115758 chr16:48599609 T/C cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg08736216 chr1:53307985 ZYG11A -0.3 -6.17 -0.32 1.96e-9 Monocyte count; LUSC cis rs7572733 0.534 rs700683 chr2:198712332 G/A cg00792783 chr2:198669748 PLCL1 0.43 5.87 0.31 1.04e-8 Dermatomyositis; LUSC trans rs6693295 0.625 rs6680215 chr1:246347153 G/A cg13514129 chr1:39547527 MACF1 0.46 6.02 0.31 4.58e-9 Migraine - clinic-based;Migraine with aura; LUSC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg21153622 chr11:89784906 NA -0.39 -5.96 -0.31 6.45e-9 HDL cholesterol; LUSC cis rs16854884 0.690 rs35885310 chr3:143771333 A/G cg06585982 chr3:143692056 C3orf58 0.5 7.73 0.39 1.25e-13 Economic and political preferences (feminism/equality); LUSC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg23625390 chr15:77176239 SCAPER 0.5 7.75 0.39 1.11e-13 Blood metabolite levels; LUSC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs7927592 0.871 rs11228284 chr11:68322767 A/T cg20283391 chr11:68216788 NA -0.61 -8.46 -0.42 8.4e-16 Total body bone mineral density; LUSC cis rs1018836 0.774 rs35159732 chr8:91633094 A/G cg16814680 chr8:91681699 NA -0.75 -11.49 -0.53 5.55e-26 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs11676348 0.772 rs11687200 chr2:218944615 A/G cg18102446 chr2:218934044 RUFY4 0.36 5.88 0.31 9.97e-9 Ulcerative colitis; LUSC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg17143192 chr8:8559678 CLDN23 0.66 9.23 0.45 3.25e-18 Obesity-related traits; LUSC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg14668632 chr7:2872130 GNA12 -0.46 -6.45 -0.33 3.83e-10 Height; LUSC cis rs4746818 1.000 rs4746817 chr10:70882515 T/C cg11621586 chr10:70884670 VPS26A 1.15 11.17 0.52 8.19e-25 Left atrial antero-posterior diameter; LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg07092213 chr7:1199455 ZFAND2A -0.41 -6.33 -0.33 7.82e-10 Longevity;Endometriosis; LUSC cis rs2637266 0.655 rs2588335 chr10:78510229 C/G cg18941641 chr10:78392320 NA 0.39 7.03 0.36 1.16e-11 Pulmonary function; LUSC cis rs6733011 0.582 rs6757099 chr2:99415235 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -6.99 -0.36 1.53e-11 Bipolar disorder; LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg26314531 chr2:26401878 FAM59B 0.72 10.03 0.48 7.17e-21 Gut microbiome composition (summer); LUSC trans rs11039798 0.660 rs28435129 chr11:48629795 A/T cg03929089 chr4:120376271 NA 0.61 6.58 0.34 1.83e-10 Axial length; LUSC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.81 0.51 1.53e-23 Monocyte percentage of white cells; LUSC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02475777 chr4:1388615 CRIPAK 0.57 8.68 0.43 1.83e-16 Longevity; LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg02475777 chr4:1388615 CRIPAK 0.62 9.17 0.45 4.98e-18 Longevity; LUSC cis rs7666738 0.515 rs13131874 chr4:98779183 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.0 0.44 1.76e-17 Colonoscopy-negative controls vs population controls; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg07607462 chr15:43398173 UBR1 0.34 5.97 0.31 6.01e-9 Tuberculosis; LUSC cis rs1670533 1.000 rs62294756 chr4:1097676 G/A cg16405210 chr4:1374714 KIAA1530 0.46 5.66 0.3 3.25e-8 Recombination rate (females); LUSC cis rs4820539 0.966 rs2301554 chr22:23484254 A/C cg14186256 chr22:23484241 RTDR1 0.98 18.93 0.72 8.55e-55 Bone mineral density; LUSC trans rs17112190 1.000 rs7090880 chr10:98559018 C/A cg05472874 chr22:44258179 SULT4A1 0.71 6.17 0.32 2.02e-9 Multiple myeloma (IgH translocation); LUSC cis rs9325144 0.541 rs7303395 chr12:38664124 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.27 -0.49 1.11e-21 Morning vs. evening chronotype; LUSC cis rs2486288 0.656 rs2413771 chr15:45553140 A/G cg26924012 chr15:45694286 SPATA5L1 -0.71 -10.62 -0.5 6.77e-23 Glomerular filtration rate; LUSC cis rs67311347 0.866 rs2371183 chr3:40334247 C/T cg13683864 chr3:40499215 RPL14 0.91 15.11 0.64 1.1e-39 Renal cell carcinoma; LUSC cis rs10752881 1.000 rs10752885 chr1:182982878 C/G ch.1.3577855R chr1:183094577 LAMC1 0.68 10.57 0.5 9.91e-23 Colorectal cancer; LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg27170947 chr2:26402098 FAM59B -0.69 -10.66 -0.5 4.93e-23 Gut microbiome composition (summer); LUSC cis rs8017423 0.935 rs8012303 chr14:90715829 G/A cg04374321 chr14:90722782 PSMC1 0.76 12.12 0.55 2.88e-28 Mortality in heart failure; LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg07212818 chr11:638076 DRD4 -0.38 -6.49 -0.33 3.07e-10 Systemic lupus erythematosus; LUSC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg01879757 chr17:41196368 BRCA1 -0.47 -7.09 -0.36 8.11e-12 Menopause (age at onset); LUSC cis rs62458065 0.640 rs10241303 chr7:32534203 T/G cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.89 -0.31 9.58e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9341808 0.718 rs1324123 chr6:80932894 G/A cg08355045 chr6:80787529 NA 0.58 10.04 0.48 6.79e-21 Sitting height ratio; LUSC trans rs4295623 0.504 rs11250160 chr8:11592717 G/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.15 -0.32 2.23e-9 Morning vs. evening chronotype; LUSC trans rs12310956 0.527 rs1608910 chr12:33895414 T/C cg13010199 chr12:38710504 ALG10B 0.48 7.56 0.38 3.82e-13 Morning vs. evening chronotype; LUSC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg13390004 chr1:15929781 NA 0.41 6.85 0.35 3.63e-11 Systolic blood pressure; LUSC cis rs11122272 0.668 rs1538664 chr1:231555295 C/T cg06096015 chr1:231504339 EGLN1 0.48 8.33 0.41 2.13e-15 Hemoglobin concentration; LUSC cis rs2625529 0.526 rs7179942 chr15:72563074 C/G cg16672083 chr15:72433130 SENP8 0.47 7.8 0.39 7.96e-14 Red blood cell count; LUSC cis rs4595586 0.545 rs7972590 chr12:39376615 A/G cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs13401104 0.796 rs1073463 chr2:237118096 G/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs41271473 0.526 rs10916337 chr1:228714902 C/T cg10167378 chr1:228756711 NA 0.73 9.33 0.45 1.48e-18 Chronic lymphocytic leukemia; LUSC cis rs9457247 1.000 rs413232 chr6:167400972 G/A cg25258033 chr6:167368657 RNASET2 0.47 7.84 0.39 6.15e-14 Crohn's disease; LUSC cis rs8072100 0.666 rs9913503 chr17:45776330 T/G cg19784903 chr17:45786737 TBKBP1 -0.43 -6.26 -0.32 1.17e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg00166722 chr3:10149974 C3orf24 0.6 8.06 0.4 1.33e-14 Alzheimer's disease; LUSC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg04369109 chr6:150039330 LATS1 -0.57 -8.44 -0.42 1e-15 Lung cancer; LUSC cis rs4363385 0.747 rs4240868 chr1:152981599 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.43e-13 Inflammatory skin disease; LUSC cis rs6500602 1.000 rs11647946 chr16:4462836 G/A cg08645402 chr16:4508243 NA 0.54 9.09 0.45 8.92e-18 Schizophrenia; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg12432903 chr7:1882776 MAD1L1 -0.5 -8.3 -0.41 2.69e-15 Bipolar disorder and schizophrenia; LUSC cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg24692254 chr21:30365293 RNF160 -0.85 -15.75 -0.65 3.56e-42 Dental caries; LUSC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.6 9.29 0.45 2.07e-18 Total body bone mineral density; LUSC trans rs800082 0.516 rs1726545 chr3:144244807 T/A cg24215973 chr2:240111563 HDAC4 0.46 7.02 0.36 1.28e-11 Smoking behavior; LUSC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg11645453 chr3:52864694 ITIH4 0.38 8.48 0.42 7.14e-16 Bipolar disorder; LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs654950 0.806 rs10749832 chr1:42041806 C/T cg06885757 chr1:42089581 HIVEP3 0.43 8.53 0.42 5.23e-16 Airway imaging phenotypes; LUSC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg04352962 chr1:209979756 IRF6 0.53 6.22 0.32 1.45e-9 Cleft lip with or without cleft palate; LUSC cis rs8078723 0.714 rs2241244 chr17:38153554 G/C cg17467752 chr17:38218738 THRA -0.71 -11.36 -0.53 1.64e-25 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.37e-13 Developmental language disorder (linguistic errors); LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg03576123 chr11:487126 PTDSS2 -0.95 -10.56 -0.5 1.11e-22 Body mass index; LUSC trans rs1814175 0.935 rs10839317 chr11:49657228 A/C cg03929089 chr4:120376271 NA -0.99 -17.82 -0.7 2.23e-50 Height; LUSC cis rs644799 0.509 rs561635 chr11:95634232 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.57 -8.05 -0.4 1.44e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg01802117 chr1:53393560 SCP2 0.4 6.53 0.34 2.43e-10 Monocyte count; LUSC cis rs3008870 0.709 rs62883160 chr1:67392889 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.76 12.44 0.56 1.91e-29 Lymphocyte percentage of white cells; LUSC cis rs2295359 0.892 rs72676067 chr1:67658803 G/A cg12940439 chr1:67600707 NA 0.39 6.2 0.32 1.7e-9 Psoriasis; LUSC cis rs78579285 0.507 rs1061247 chr16:88781791 A/C cg01900006 chr16:88814613 FAM38A 0.51 5.66 0.3 3.33e-8 Joint mobility (Beighton score); LUSC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg15445000 chr17:37608096 MED1 0.41 6.89 0.35 2.81e-11 Glomerular filtration rate (creatinine); LUSC cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.48 0.65 4.06e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs12421382 0.593 rs1808842 chr11:109389454 C/T cg11473876 chr11:109292803 C11orf87 0.35 5.97 0.31 5.95e-9 Schizophrenia; LUSC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg06212747 chr3:49208901 KLHDC8B 0.44 5.98 0.31 5.68e-9 Parkinson's disease; LUSC cis rs796825 0.530 rs4676676 chr3:119987645 C/T cg21790991 chr3:120137480 FSTL1 -0.34 -6.1 -0.32 2.93e-9 HIV-1 susceptibility; LUSC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.55 0.62 1.76e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.3e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs4499344 0.633 rs259262 chr19:33153951 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.42 0.53 1.02e-25 Mean platelet volume; LUSC cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg23711669 chr6:146136114 FBXO30 0.87 16.12 0.66 1.19e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs6456156 0.586 rs13195158 chr6:167481392 G/A cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg03676636 chr4:99064102 C4orf37 0.38 8.0 0.4 2.1e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.89 0.51 7.85e-24 Hip circumference adjusted for BMI; LUSC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg23158103 chr7:148848205 ZNF398 -0.42 -6.6 -0.34 1.57e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg07424592 chr7:64974309 NA 0.69 6.19 0.32 1.81e-9 Diabetic kidney disease; LUSC cis rs6977660 1.000 rs7812001 chr7:19803323 A/G cg07541023 chr7:19748670 TWISTNB -0.57 -6.6 -0.34 1.61e-10 Thyroid stimulating hormone; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19455335 chr8:22457658 C8orf58 0.42 6.26 0.32 1.18e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs79349575 0.721 rs1008834 chr17:46968008 G/C cg22482690 chr17:47019901 SNF8 0.4 7.47 0.38 6.92e-13 Type 2 diabetes; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11644478 chr21:40555479 PSMG1 0.77 13.29 0.59 1.21e-32 Cognitive function; LUSC cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg00579200 chr11:133705235 NA -0.39 -5.97 -0.31 6.21e-9 Childhood ear infection; LUSC cis rs7312933 0.510 rs61942483 chr12:42499538 T/A cg17420585 chr12:42539391 GXYLT1 -0.57 -13.18 -0.58 3.23e-32 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg21361702 chr7:150065534 REPIN1 0.5 6.79 0.35 5.18e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs3741798 1.000 rs61922047 chr12:12496471 C/A cg08615371 chr12:12503544 MANSC1 1.08 11.07 0.52 1.79e-24 Cerebrospinal fluid biomarker levels; LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.89 0.75 1.43e-62 Prudent dietary pattern; LUSC trans rs9393777 0.920 rs34071253 chr6:27391802 C/T cg06606381 chr12:133084897 FBRSL1 -0.89 -8.93 -0.44 2.85e-17 Intelligence (multi-trait analysis); LUSC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.73 0.3 2.25e-8 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg09365446 chr1:150670422 GOLPH3L -0.46 -6.88 -0.35 2.87e-11 Melanoma; LUSC cis rs6504663 0.596 rs7208018 chr17:48557863 C/T cg03611598 chr17:48586076 MYCBPAP -0.49 -6.19 -0.32 1.81e-9 Visceral fat; LUSC cis rs1712517 0.835 rs2506961 chr10:105007926 G/T cg05636881 chr10:105038444 INA -0.42 -6.91 -0.35 2.4e-11 Migraine; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11858416 chr22:29279592 ZNRF3 -0.42 -6.33 -0.33 7.9e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2055729 0.885 rs13268133 chr8:9731470 C/T cg27411982 chr8:10470053 RP1L1 0.41 5.93 0.31 7.41e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg05340658 chr4:99064831 C4orf37 0.67 11.56 0.53 3.25e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9462027 0.527 rs6939600 chr6:34822176 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.09e-8 Systemic lupus erythematosus; LUSC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.43 7.41 0.38 1.02e-12 Electroencephalogram traits; LUSC cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg12310025 chr6:25882481 NA -0.37 -6.3 -0.33 9.33e-10 Intelligence (multi-trait analysis); LUSC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg11645453 chr3:52864694 ITIH4 0.34 7.89 0.4 4.4e-14 Electroencephalogram traits; LUSC cis rs12701220 0.739 rs2293523 chr7:1098518 G/A cg26769984 chr7:1090371 C7orf50 0.58 7.3 0.37 2.18e-12 Bronchopulmonary dysplasia; LUSC cis rs7914558 1.000 rs7896547 chr10:104866958 A/G cg05855489 chr10:104503620 C10orf26 0.6 9.66 0.47 1.28e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11625487 0.915 rs11845826 chr14:77966145 C/A cg16049707 chr14:77965284 ISM2 0.6 8.58 0.43 3.58e-16 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC trans rs67133203 0.904 rs12831269 chr12:51398441 C/T cg17484237 chr5:156536107 HAVCR2 0.44 5.99 0.31 5.35e-9 Urinary tract infection frequency; LUSC cis rs1983891 1.000 rs9296365 chr6:41535379 A/G cg15051332 chr6:41514432 FOXP4 0.39 5.69 0.3 2.84e-8 Prostate cancer; LUSC cis rs13223928 0.621 rs10228451 chr7:3150859 C/G cg19214707 chr7:3157722 NA 0.42 8.46 0.42 8.26e-16 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs12900413 0.603 rs2351493 chr15:90299536 A/G cg24249390 chr15:90295951 MESP1 -0.37 -5.9 -0.31 8.76e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1670533 1.000 rs7679432 chr4:1050521 G/A cg27284194 chr4:1044797 NA 0.57 8.42 0.42 1.12e-15 Recombination rate (females); LUSC cis rs7572733 0.534 rs700680 chr2:198707950 A/T cg00792783 chr2:198669748 PLCL1 -0.43 -5.95 -0.31 6.91e-9 Dermatomyositis; LUSC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg04287289 chr16:89883240 FANCA 0.77 6.21 0.32 1.57e-9 Skin colour saturation; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg12432903 chr7:1882776 MAD1L1 -0.37 -5.8 -0.3 1.56e-8 Bipolar disorder and schizophrenia; LUSC cis rs4654899 1.000 rs4654902 chr1:21435056 T/G cg01072550 chr1:21505969 NA -0.53 -8.07 -0.4 1.27e-14 Superior frontal gyrus grey matter volume; LUSC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs240764 0.687 rs239248 chr6:101088315 T/A cg09795085 chr6:101329169 ASCC3 0.42 6.12 0.32 2.68e-9 Neuroticism; LUSC cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 10.66 0.5 4.87e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs34734847 0.750 rs3915 chr12:121176679 C/T cg27246729 chr12:121163418 ACADS 0.4 6.25 0.32 1.25e-9 Mean corpuscular volume; LUSC cis rs8027181 0.839 rs4777532 chr15:73041767 A/G cg25632853 chr15:73088954 NA 0.31 6.4 0.33 5.34e-10 Triglyceride levels; LUSC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg04733989 chr22:42467013 NAGA -0.41 -6.76 -0.35 6.04e-11 Cognitive function; LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg13126279 chr21:47581558 C21orf56 -0.52 -7.84 -0.39 5.9e-14 Testicular germ cell tumor; LUSC cis rs2346177 0.542 rs6757564 chr2:46702619 G/C cg02822958 chr2:46747628 ATP6V1E2 0.5 9.25 0.45 2.82e-18 HDL cholesterol; LUSC cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg13535736 chr9:111863775 C9orf5 -0.4 -6.5 -0.34 2.93e-10 Menarche (age at onset); LUSC cis rs12760731 0.565 rs12030488 chr1:178094751 A/C cg00404053 chr1:178313656 RASAL2 -0.66 -6.86 -0.35 3.29e-11 Obesity-related traits; LUSC cis rs8060686 0.516 rs1971546 chr16:68280893 T/C cg05110241 chr16:68378359 PRMT7 -0.53 -6.56 -0.34 2.04e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9400467 0.509 rs463854 chr6:111673207 C/G cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg02269571 chr22:50332266 NA 0.59 8.74 0.43 1.17e-16 Schizophrenia; LUSC cis rs11997175 0.587 rs72612118 chr8:33695225 T/C ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.2e-10 Body mass index; LUSC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.27e-8 Aortic root size; LUSC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.74 0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs12893668 0.645 rs35229468 chr14:104052057 C/T cg08213375 chr14:104286397 PPP1R13B 0.34 5.77 0.3 1.78e-8 Reticulocyte count; LUSC cis rs72949976 0.707 rs62186571 chr2:214038673 C/G cg08319019 chr2:214017104 IKZF2 -0.54 -7.28 -0.37 2.39e-12 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg08493051 chr2:3487164 NA -0.56 -8.8 -0.43 7.33e-17 Neurofibrillary tangles; LUSC trans rs17266958 1.000 rs62576986 chr9:83294455 T/C cg01905489 chr1:26616534 UBXN11 -0.51 -5.95 -0.31 6.9e-9 Preschool internalizing problems; LUSC cis rs9560113 1.000 rs11069895 chr13:112178824 C/T cg14154082 chr13:112174009 NA 0.37 7.62 0.38 2.72e-13 Menarche (age at onset); LUSC cis rs9815354 0.812 rs73828254 chr3:41810180 T/A cg03022575 chr3:42003672 ULK4 0.83 8.32 0.41 2.2e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs6696846 0.740 rs17344537 chr1:205091427 T/G cg00857998 chr1:205179979 DSTYK 0.65 10.16 0.49 2.63e-21 Red blood cell count; LUSC cis rs4494114 1.000 rs4491033 chr1:39352083 A/C cg25970120 chr1:39325951 RRAGC -0.38 -6.0 -0.31 5.06e-9 Blood protein levels; LUSC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg06221963 chr1:154839813 KCNN3 0.59 12.92 0.58 2.92e-31 Prostate cancer; LUSC cis rs868036 1.000 rs1471460 chr15:68089299 G/A cg05925327 chr15:68127851 NA -0.32 -5.75 -0.3 2.02e-8 Restless legs syndrome; LUSC trans rs7829975 0.514 rs2976926 chr8:8261624 T/C cg27411982 chr8:10470053 RP1L1 0.38 6.1 0.32 2.94e-9 Mood instability; LUSC cis rs68170813 0.559 rs2189501 chr7:106942766 A/T cg02696742 chr7:106810147 HBP1 -0.64 -9.7 -0.47 8.88e-20 Coronary artery disease; LUSC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg14895029 chr7:2775587 GNA12 -0.38 -5.81 -0.3 1.44e-8 Height; LUSC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg04546413 chr19:29218101 NA 0.52 7.38 0.37 1.24e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg09165964 chr15:75287851 SCAMP5 0.46 6.94 0.35 2.09e-11 Breast cancer; LUSC cis rs61931739 0.534 rs10844732 chr12:34037104 A/C cg06521331 chr12:34319734 NA -0.48 -7.71 -0.39 1.43e-13 Morning vs. evening chronotype; LUSC cis rs11122272 0.735 rs2486743 chr1:231506928 C/G cg06096015 chr1:231504339 EGLN1 0.56 9.95 0.48 1.33e-20 Hemoglobin concentration; LUSC cis rs2197308 0.728 rs7304305 chr12:37932990 T/C cg13010199 chr12:38710504 ALG10B -0.6 -9.33 -0.45 1.56e-18 Morning vs. evening chronotype; LUSC cis rs7615316 0.528 rs7636909 chr3:142260562 A/G cg16271453 chr3:142027066 XRN1 -0.5 -8.82 -0.43 6.64e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs950169 0.881 rs72750843 chr15:85135783 C/T cg12863693 chr15:85201151 NMB 0.35 6.89 0.35 2.73e-11 Schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18497098 chr6:83775582 UBE2CBP 0.73 6.17 0.32 2.02e-9 Cognitive performance; LUSC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg12463550 chr7:65579703 CRCP -0.52 -7.51 -0.38 5.35e-13 Aortic root size; LUSC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.34 6.14 0.32 2.28e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs654950 0.841 rs2810549 chr1:41991761 C/T cg06885757 chr1:42089581 HIVEP3 -0.37 -7.28 -0.37 2.38e-12 Airway imaging phenotypes; LUSC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg06481639 chr22:41940642 POLR3H 0.49 5.81 0.3 1.48e-8 Vitiligo; LUSC cis rs9467711 0.606 rs72836482 chr6:26359241 A/T cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg14019146 chr3:50243930 SLC38A3 0.36 8.26 0.41 3.53e-15 Body mass index; LUSC cis rs7188861 0.768 rs62023624 chr16:11399603 C/A cg00044050 chr16:11439710 C16orf75 0.51 5.83 0.3 1.32e-8 HDL cholesterol; LUSC cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg12698349 chr2:225449008 CUL3 0.72 9.08 0.44 9.6e-18 IgE levels in asthmatics (D.p. specific); LUSC cis rs6582630 0.623 rs12299293 chr12:38436288 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.55 -0.34 2.12e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs11098499 0.954 rs10006706 chr4:120409152 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.71 0.39 1.48e-13 Corneal astigmatism; LUSC cis rs7178572 0.568 rs7176302 chr15:77671216 C/G cg22256960 chr15:77711686 NA -0.51 -8.09 -0.4 1.11e-14 Type 2 diabetes; LUSC cis rs17102423 0.689 rs7158239 chr14:65520616 G/A cg11161011 chr14:65562177 MAX -0.58 -8.87 -0.44 4.37e-17 Obesity-related traits; LUSC cis rs2932538 0.922 rs12138335 chr1:113122760 T/C cg22162597 chr1:113214053 CAPZA1 0.7 10.06 0.48 5.71e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs921968 0.541 rs581013 chr2:219432040 G/T cg02176678 chr2:219576539 TTLL4 0.75 14.64 0.63 7.48e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs3099143 1.000 rs2629034 chr15:77042240 G/A cg21673338 chr15:77095150 SCAPER -0.82 -8.07 -0.4 1.26e-14 Recalcitrant atopic dermatitis; LUSC cis rs929354 0.553 rs34498858 chr7:156931337 T/C cg05182265 chr7:156933206 UBE3C -0.57 -9.18 -0.45 4.64e-18 Body mass index; LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.37 0.37 1.35e-12 Bipolar disorder; LUSC cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -14.2 -0.61 4e-36 Chronic sinus infection; LUSC cis rs2834256 0.517 rs7280365 chr21:34952583 G/C cg14850771 chr21:34775459 IFNGR2 0.39 5.68 0.3 2.86e-8 Red cell distribution width; LUSC cis rs2354432 0.556 rs1932979 chr1:146708912 A/G cg25205988 chr1:146714368 CHD1L -1.01 -8.99 -0.44 1.91e-17 Mitochondrial DNA levels; LUSC cis rs977987 0.843 rs7499872 chr16:75426529 G/A cg04384234 chr16:75411784 CFDP1 -0.45 -7.41 -0.38 1.04e-12 Dupuytren's disease; LUSC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg17376030 chr22:41985996 PMM1 0.46 5.85 0.3 1.2e-8 Vitiligo; LUSC cis rs7809950 1.000 rs986994 chr7:107104115 G/T cg23024343 chr7:107201750 COG5 -0.54 -8.76 -0.43 9.95e-17 Coronary artery disease; LUSC cis rs4629710 0.617 rs28360555 chr6:131538952 C/A cg12700074 chr6:131571435 AKAP7 -0.37 -6.15 -0.32 2.17e-9 Multiple myeloma (IgH translocation); LUSC cis rs2299587 0.519 rs3850746 chr8:17787536 C/T cg01800426 chr8:17659068 MTUS1 0.46 6.3 0.33 9.15e-10 Economic and political preferences; LUSC trans rs1908814 0.516 rs10113145 chr8:11793295 A/G cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.64e-16 Neuroticism; LUSC cis rs2637266 0.967 rs4553314 chr10:78358244 C/T cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.53e-12 Pulmonary function; LUSC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg11941060 chr3:133502564 NA -0.42 -6.12 -0.32 2.68e-9 Iron status biomarkers; LUSC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg21856205 chr7:94953877 PON1 -0.36 -5.69 -0.3 2.72e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7937682 0.601 rs2187388 chr11:111387116 C/T cg09085632 chr11:111637200 PPP2R1B 0.51 6.7 0.34 9e-11 Primary sclerosing cholangitis; LUSC cis rs3931020 0.688 rs277374 chr1:75200486 G/A cg21535942 chr1:75199100 CRYZ;TYW3 -0.47 -5.93 -0.31 7.37e-9 Resistin levels; LUSC cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.53e-9 Breast cancer; LUSC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg14983838 chr19:29218262 NA 0.65 9.21 0.45 3.62e-18 Methadone dose in opioid dependence; LUSC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg23281280 chr6:28129359 ZNF389 0.43 5.72 0.3 2.38e-8 Parkinson's disease; LUSC cis rs7089973 0.523 rs11197017 chr10:116737738 C/A cg23260525 chr10:116636907 FAM160B1 0.29 5.68 0.3 2.97e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg08470875 chr2:26401718 FAM59B -0.69 -9.28 -0.45 2.21e-18 Gut microbiome composition (summer); LUSC trans rs6502050 0.805 rs6502057 chr17:80082060 A/G cg07393940 chr7:158741817 NA -0.37 -6.65 -0.34 1.22e-10 Life satisfaction; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg16980360 chr17:29298148 RNF135 -0.49 -6.18 -0.32 1.9e-9 Neuroticism; LUSC cis rs10992471 0.580 rs7847534 chr9:95282653 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.9 -0.35 2.68e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs892085 0.681 rs7246673 chr19:10876841 T/G cg17710535 chr19:10819994 QTRT1 0.34 5.66 0.3 3.21e-8 Psoriasis vulgaris;Psoriasis; LUSC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg08219700 chr8:58056026 NA 0.65 7.64 0.39 2.29e-13 Developmental language disorder (linguistic errors); LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg07507251 chr3:52567010 NT5DC2 0.36 7.19 0.37 4.16e-12 Electroencephalogram traits; LUSC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg15147215 chr3:52552868 STAB1 0.29 5.7 0.3 2.69e-8 Electroencephalogram traits; LUSC cis rs28374715 0.532 rs7168431 chr15:41672384 A/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -22.83 -0.78 3.76e-70 Ulcerative colitis; LUSC cis rs12519773 0.846 rs1496332 chr5:92439320 A/G cg18783429 chr5:92414398 NA 0.29 6.4 0.33 5.16e-10 Migraine; LUSC cis rs752010 0.695 rs10890156 chr1:42108090 T/C cg06885757 chr1:42089581 HIVEP3 0.44 8.53 0.42 5.25e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs6546886 0.957 rs11885172 chr2:74257094 T/C cg14702570 chr2:74259524 NA -0.3 -5.78 -0.3 1.7e-8 Dialysis-related mortality; LUSC cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg09537434 chr19:41945824 ATP5SL -0.64 -9.24 -0.45 2.99e-18 Migraine;Coronary artery disease; LUSC cis rs9905704 0.633 rs2531727 chr17:56502264 C/T cg19466818 chr17:56409534 MIR142 -0.32 -6.08 -0.32 3.26e-9 Testicular germ cell tumor; LUSC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg10802521 chr3:52805072 NEK4 -0.52 -8.0 -0.4 2e-14 Bipolar disorder; LUSC cis rs354225 0.544 rs12713268 chr2:54808845 C/G cg26097391 chr2:54893211 SPTBN1 -0.4 -6.19 -0.32 1.73e-9 Schizophrenia; LUSC cis rs11677370 0.603 rs10198219 chr2:3854600 T/C cg17052675 chr2:3827356 NA -0.63 -10.1 -0.48 4.21e-21 Type 2 diabetes; LUSC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09241243 chr14:64970743 ZBTB25;ZBTB1 0.73 5.69 0.3 2.73e-8 Cognitive performance; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg07066635 chr12:110434276 GIT2 0.47 5.98 0.31 5.68e-9 Neuroticism; LUSC cis rs7746199 0.736 rs13212318 chr6:27688841 A/C cg26958806 chr6:27640298 NA 0.74 6.04 0.31 4.02e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs67539049 1.000 rs67526040 chr8:11302996 G/A cg26241650 chr22:40417538 FAM83F 0.43 5.95 0.31 6.83e-9 Itch intensity from mosquito bite; LUSC cis rs40363 1.000 rs1690443 chr16:3517787 C/G cg00484396 chr16:3507460 NAT15 0.86 11.42 0.53 9.83e-26 Tuberculosis; LUSC cis rs6977940 0.818 rs35450876 chr7:2894852 A/G cg19731401 chr7:2775893 GNA12 0.65 7.31 0.37 2.04e-12 White matter integrity; LUSC cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.52 0.42 5.39e-16 Menopause (age at onset); LUSC cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg17691542 chr6:26056736 HIST1H1C 0.49 7.22 0.37 3.46e-12 Height; LUSC cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg09184832 chr6:79620586 NA 0.42 6.63 0.34 1.35e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg22920501 chr2:26401640 FAM59B -0.81 -12.05 -0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs10740039 0.883 rs2119912 chr10:62399512 C/A cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg16624210 chr5:671434 TPPP 0.49 6.1 0.32 2.89e-9 Lung disease severity in cystic fibrosis; LUSC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg02018176 chr4:1364513 KIAA1530 0.53 9.01 0.44 1.61e-17 Obesity-related traits; LUSC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg12560992 chr17:57184187 TRIM37 0.85 15.53 0.65 2.58e-41 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.966 rs6037103 chr20:25369095 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.75 -0.73 4.73e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11098499 0.908 rs1002152 chr4:120273387 C/A cg09307838 chr4:120376055 NA 0.77 11.34 0.53 1.91e-25 Corneal astigmatism; LUSC cis rs12541635 0.934 rs4734893 chr8:106990275 T/G cg10147462 chr8:107024639 NA 0.56 10.1 0.48 4.04e-21 Age of smoking initiation; LUSC cis rs2798269 1.000 rs2761911 chr13:22131801 T/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.13 -0.32 2.42e-9 PR segment; LUSC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg03388025 chr16:89894329 SPIRE2 0.34 7.07 0.36 9.13e-12 Vitiligo; LUSC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg04287289 chr16:89883240 FANCA 0.78 6.24 0.32 1.3e-9 Skin colour saturation; LUSC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -8.74 -0.43 1.16e-16 Hemoglobin concentration; LUSC cis rs6674970 1.000 rs6656450 chr1:151089602 A/T cg03258749 chr1:151040405 MLLT11 -0.43 -6.45 -0.33 3.86e-10 Childhood ear infection; LUSC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7428496 0.528 rs13092234 chr3:142273836 G/C cg16271453 chr3:142027066 XRN1 -0.49 -8.48 -0.42 7.25e-16 Mean corpuscular hemoglobin; LUSC cis rs7617773 0.817 rs936426 chr3:48215253 C/T cg11946769 chr3:48343235 NME6 0.82 13.51 0.59 1.7e-33 Coronary artery disease; LUSC trans rs7613875 0.600 rs1061474 chr3:50144951 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.52 -8.11 -0.41 9.52e-15 Body mass index; LUSC cis rs12760731 0.565 rs35926996 chr1:178075351 A/G cg00404053 chr1:178313656 RASAL2 0.67 6.7 0.34 8.81e-11 Obesity-related traits; LUSC cis rs16854884 1.000 rs7649614 chr3:143789028 G/A cg06585982 chr3:143692056 C3orf58 0.46 6.35 0.33 7.15e-10 Economic and political preferences (feminism/equality); LUSC cis rs10752881 0.967 rs6695837 chr1:182991462 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 10.44 0.5 2.94e-22 Colorectal cancer; LUSC trans rs3733585 0.781 rs13103879 chr4:9972879 T/C cg26043149 chr18:55253948 FECH -0.47 -7.29 -0.37 2.19e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10207060 0.500 rs28540721 chr2:240714045 C/T cg20333904 chr2:240724165 NA -0.35 -6.07 -0.32 3.43e-9 Obesity-related traits; LUSC cis rs12289510 1.000 rs12289510 chr11:124947051 C/T cg03868193 chr11:124958746 SLC37A2 0.56 8.98 0.44 1.97e-17 Platelet-derived growth factor BB levels; LUSC cis rs8060686 0.545 rs17688076 chr16:68286427 C/A cg05110241 chr16:68378359 PRMT7 -0.69 -7.3 -0.37 2.09e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg02569458 chr12:86230093 RASSF9 0.58 9.89 0.48 2.1e-20 Major depressive disorder; LUSC cis rs2445762 0.518 rs6493496 chr15:51628119 A/T cg00184732 chr15:51633821 GLDN 0.3 6.02 0.31 4.64e-9 Hormone measurements; LUSC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg14784868 chr12:69753453 YEATS4 0.82 14.29 0.62 1.77e-36 Blood protein levels; LUSC cis rs7481584 0.581 rs406598 chr11:3076285 G/A cg08508325 chr11:3079039 CARS 0.38 8.4 0.42 1.33e-15 Calcium levels; LUSC cis rs62458065 1.000 rs6462364 chr7:32464776 C/T cg20159608 chr7:32802032 NA -0.57 -7.01 -0.36 1.34e-11 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9420 0.528 rs10896632 chr11:57390302 G/A cg23127183 chr11:57508653 C11orf31 -0.48 -6.68 -0.34 9.81e-11 Schizophrenia; LUSC cis rs12410462 0.681 rs74582965 chr1:227610126 C/T cg10327440 chr1:227177885 CDC42BPA -0.64 -5.78 -0.3 1.73e-8 Major depressive disorder; LUSC cis rs478304 0.934 rs12801731 chr11:65549606 T/C cg05805236 chr11:65401703 PCNXL3 0.39 6.63 0.34 1.33e-10 Acne (severe); LUSC cis rs9633740 0.773 rs7080009 chr10:82269461 T/C cg01528321 chr10:82214614 TSPAN14 1.08 11.99 0.55 8.7e-28 Post bronchodilator FEV1; LUSC cis rs859767 0.774 rs6758396 chr2:135416857 T/C cg12500956 chr2:135428796 TMEM163 -0.27 -6.13 -0.32 2.46e-9 Neuroticism; LUSC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg12927641 chr6:109611667 NA 0.37 6.23 0.32 1.37e-9 Reticulocyte fraction of red cells; LUSC cis rs185694 0.779 rs653221 chr13:30894567 G/C cg07600127 chr13:30881527 KATNAL1 -0.51 -5.97 -0.31 6.21e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; LUSC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg05425664 chr17:57184151 TRIM37 -0.52 -7.83 -0.39 6.45e-14 Intelligence (multi-trait analysis); LUSC trans rs3733585 0.673 rs7378340 chr4:9955198 C/T cg26043149 chr18:55253948 FECH -0.45 -6.92 -0.35 2.31e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -9.85 -0.47 2.84e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs6495367 1.000 rs3851677 chr15:79380869 C/T cg17916960 chr15:79447300 NA 0.35 6.67 0.34 1.04e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.37 -6.02 -0.31 4.48e-9 Personality dimensions; LUSC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg15704280 chr7:45808275 SEPT13 0.93 13.36 0.59 6.38e-33 Coronary artery disease; LUSC cis rs9325144 0.581 rs2730929 chr12:38942739 T/C cg26384229 chr12:38710491 ALG10B -0.71 -11.7 -0.54 9.99e-27 Morning vs. evening chronotype; LUSC cis rs2836633 1.000 rs2836634 chr21:40068230 T/A cg12884169 chr21:40033163 ERG 0.56 11.08 0.52 1.62e-24 Coronary artery disease; LUSC cis rs7814319 0.966 rs2319603 chr8:97270991 G/A cg20787634 chr8:97240163 UQCRB -0.35 -6.12 -0.32 2.62e-9 Lung function (FVC); LUSC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.19 21.79 0.77 3.98e-66 Age-related macular degeneration (geographic atrophy); LUSC trans rs1376359 0.537 rs537755 chr1:103260776 G/C cg17154563 chr19:40477487 PSMC4 0.48 6.06 0.31 3.61e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7100689 0.784 rs7082705 chr10:82170856 C/T cg01528321 chr10:82214614 TSPAN14 -1.06 -17.15 -0.68 9.98e-48 Post bronchodilator FEV1; LUSC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.49 8.33 0.41 2.16e-15 Total body bone mineral density; LUSC cis rs11229555 0.645 rs11229443 chr11:58197188 G/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg04865166 chr7:105162814 PUS7 0.51 5.84 0.3 1.25e-8 Bipolar disorder (body mass index interaction); LUSC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.68 0.34 1e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3806843 0.576 rs246017 chr5:140335060 C/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2274273 0.935 rs8004787 chr14:55607366 C/T cg04306507 chr14:55594613 LGALS3 0.58 13.35 0.59 6.92e-33 Protein biomarker; LUSC cis rs2658782 0.789 rs3019206 chr11:93111073 A/G cg15737290 chr11:93063684 CCDC67 0.64 7.91 0.4 3.87e-14 Pulmonary function decline; LUSC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.66 10.54 0.5 1.27e-22 Cognitive test performance; LUSC cis rs6087771 0.650 rs6060395 chr20:30219823 G/C cg18721089 chr20:30220636 NA -0.34 -5.93 -0.31 7.53e-9 Subcortical brain region volumes;Putamen volume; LUSC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg09359103 chr1:154839909 KCNN3 -0.58 -11.8 -0.54 4.43e-27 Prostate cancer; LUSC cis rs208520 0.526 rs6913344 chr6:66754285 A/C cg07460842 chr6:66804631 NA -1.17 -24.06 -0.8 6.35e-75 Exhaled nitric oxide output; LUSC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg12463550 chr7:65579703 CRCP -0.55 -8.12 -0.41 9.02e-15 Aortic root size; LUSC cis rs1371867 0.875 rs1788187 chr8:101336099 A/G cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.37e-11 Atrioventricular conduction; LUSC cis rs35123781 1.000 rs585101 chr5:139058454 T/C cg10513866 chr5:139070639 NA 0.47 9.14 0.45 6.25e-18 Schizophrenia; LUSC cis rs3892630 0.878 rs6510277 chr19:33183669 C/A cg22980127 chr19:33182716 NUDT19 0.95 12.94 0.58 2.44e-31 Red blood cell traits; LUSC cis rs155076 1.000 rs155076 chr13:21870114 A/G cg25811766 chr13:21894605 NA -0.69 -8.16 -0.41 6.96e-15 White matter hyperintensity burden; LUSC cis rs1371867 0.775 rs3020183 chr8:101233297 A/T cg06002616 chr8:101225028 SPAG1 0.46 7.56 0.38 4.05e-13 Atrioventricular conduction; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.4e-14 Prudent dietary pattern; LUSC cis rs7511006 0.798 rs11703673 chr22:50652427 A/G cg08875078 chr22:50639485 SELO -0.43 -5.83 -0.3 1.3e-8 Obesity-related traits; LUSC cis rs2348418 0.831 rs7977525 chr12:28715517 A/G cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs6062509 1.000 rs6011066 chr20:62364180 G/A cg21849932 chr20:62369462 LIME1 -0.41 -5.95 -0.31 6.8e-9 Prostate cancer; LUSC cis rs7106204 0.609 rs12788920 chr11:24284514 C/T ch.11.24196551F chr11:24239977 NA 0.72 6.04 0.31 4.08e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4363385 0.747 rs4568784 chr1:152972694 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -5.67 -0.3 3.09e-8 Inflammatory skin disease; LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg08740729 chr20:35491708 C20orf117 -0.4 -6.0 -0.31 5.23e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs8099014 0.601 rs4503880 chr18:56084054 A/G cg12907477 chr18:56117327 MIR122 0.41 5.81 0.3 1.46e-8 Platelet count; LUSC cis rs2303282 0.690 rs2440473 chr16:56433534 A/G cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.88e-12 Breast cancer; LUSC cis rs6460942 0.915 rs2216050 chr7:12304073 T/C cg06484146 chr7:12443880 VWDE -0.52 -6.29 -0.33 9.98e-10 Coronary artery disease; LUSC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21659725 chr3:3221576 CRBN -0.87 -17.82 -0.7 2.23e-50 Intelligence (multi-trait analysis); LUSC cis rs9326248 0.861 rs11216172 chr11:116749878 G/A cg26566898 chr11:117069891 TAGLN 0.42 7.22 0.37 3.64e-12 Blood protein levels; LUSC cis rs12421382 1.000 rs12421382 chr11:109378071 C/T cg11473876 chr11:109292803 C11orf87 0.41 6.47 0.33 3.54e-10 Schizophrenia; LUSC cis rs2540226 0.655 rs2160199 chr2:39930191 A/G cg23576258 chr2:39999331 THUMPD2 0.35 5.9 0.31 8.74e-9 Personality dimensions; LUSC cis rs11048434 0.736 rs1805722 chr12:9145056 T/C cg23795048 chr12:9217529 LOC144571 0.34 5.86 0.31 1.1e-8 Sjögren's syndrome; LUSC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg04166393 chr7:2884313 GNA12 0.41 5.82 0.3 1.36e-8 Height; LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -7.81 -0.39 7.54e-14 Lymphocyte counts; LUSC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs7180079 0.620 rs11071803 chr15:64965815 G/T cg08069370 chr15:64387884 SNX1 -0.5 -5.74 -0.3 2.16e-8 Monocyte count; LUSC cis rs9399135 0.507 rs2072825 chr6:135253451 A/G cg24558204 chr6:135376177 HBS1L -0.59 -8.67 -0.43 1.9e-16 Red blood cell count; LUSC cis rs9300255 0.602 rs2851450 chr12:123703501 C/T cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg22569836 chr15:43028916 CDAN1 0.36 6.04 0.31 4.02e-9 Educational attainment (years of education); LUSC cis rs7674212 0.507 rs223331 chr4:103793565 T/A cg16532752 chr4:104119610 CENPE -0.42 -5.72 -0.3 2.41e-8 Type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03480210 chr2:39103037 DHX57;MORN2 -0.43 -6.42 -0.33 4.61e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg04944784 chr2:26401820 FAM59B 0.68 10.16 0.49 2.67e-21 Gut microbiome composition (summer); LUSC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.12 -0.32 2.62e-9 Total body bone mineral density; LUSC cis rs4631830 0.657 rs2611502 chr10:51500301 A/G cg16070123 chr10:51489643 NA -0.58 -9.66 -0.47 1.24e-19 Prostate-specific antigen levels; LUSC cis rs7647973 1.000 rs11710434 chr3:49346130 T/C cg07636037 chr3:49044803 WDR6 0.65 8.63 0.43 2.52e-16 Menarche (age at onset); LUSC cis rs780094 0.606 rs6729709 chr2:27583156 G/A cg27432699 chr2:27873401 GPN1 -0.51 -7.63 -0.39 2.43e-13 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs2562456 0.755 rs2914646 chr19:21637161 A/C cg00806126 chr19:22604979 ZNF98 0.4 6.14 0.32 2.4e-9 Pain; LUSC cis rs7560272 0.538 rs3980695 chr2:73939552 A/G cg20560298 chr2:73613845 ALMS1 0.41 6.19 0.32 1.71e-9 Schizophrenia; LUSC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg00166722 chr3:10149974 C3orf24 0.42 6.21 0.32 1.56e-9 Alzheimer's disease; LUSC cis rs9549260 0.564 rs9577110 chr13:41271878 T/G cg21288729 chr13:41239152 FOXO1 0.54 8.3 0.41 2.7e-15 Red blood cell count; LUSC cis rs559928 1.000 rs72926046 chr11:64143387 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 6.79 0.35 5.13e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7202877 0.706 rs4887813 chr16:75312494 A/G cg03315344 chr16:75512273 CHST6 0.43 6.18 0.32 1.87e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.81 -0.3 1.44e-8 Alzheimer's disease (late onset); LUSC cis rs477692 0.967 rs488143 chr10:131407369 A/C cg11019008 chr10:131425282 MGMT 0.44 6.65 0.34 1.21e-10 Response to temozolomide; LUSC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg11812906 chr14:75593930 NEK9 -0.64 -10.04 -0.48 6.67e-21 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg21580350 chr7:148680565 NA -0.49 -6.34 -0.33 7.42e-10 Hepatitis; LUSC cis rs1797081 1.000 rs812426 chr10:16857133 C/G cg23933602 chr10:16859644 RSU1 1.06 24.09 0.8 4.92e-75 Platelet distribution width; LUSC cis rs2731664 0.792 rs2731662 chr5:176872494 C/T cg23176889 chr5:176863531 GRK6 0.66 13.72 0.6 2.73e-34 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg01579765 chr21:45077557 HSF2BP -0.52 -10.93 -0.51 5.71e-24 Mean corpuscular volume; LUSC cis rs9467773 1.000 rs9467796 chr6:26568411 A/G cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.96 15.89 0.66 9.4e-43 Platelet count; LUSC cis rs12999616 0.817 rs35530168 chr2:98328477 C/G cg26665480 chr2:98280029 ACTR1B 0.53 6.05 0.31 3.91e-9 Colorectal cancer; LUSC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg00800038 chr16:89945340 TCF25 -0.76 -6.58 -0.34 1.78e-10 Skin colour saturation; LUSC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg09367891 chr1:107599246 PRMT6 0.47 7.35 0.37 1.55e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.85e-13 Obesity-related traits; LUSC cis rs11971779 0.680 rs10274480 chr7:139052428 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.23 0.32 1.4e-9 Diisocyanate-induced asthma; LUSC cis rs77741769 0.926 rs4767941 chr12:121359586 G/A cg02403541 chr12:121454288 C12orf43 0.51 7.48 0.38 6.41e-13 Mean corpuscular volume; LUSC cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg11266682 chr4:10021025 SLC2A9 0.57 10.37 0.49 5.01e-22 Bone mineral density; LUSC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg04317338 chr11:64019027 PLCB3 0.66 7.51 0.38 5.28e-13 Mean platelet volume; LUSC cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.93 -0.51 5.8e-24 Alzheimer's disease (late onset); LUSC cis rs240764 0.578 rs12215909 chr6:101227598 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.2 -0.32 1.62e-9 Neuroticism; LUSC cis rs7726839 0.794 rs6883536 chr5:599274 G/A cg09021430 chr5:549028 NA -0.6 -9.41 -0.46 8.29e-19 Obesity-related traits; LUSC cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.82 12.4 0.56 2.57e-29 Cognitive test performance; LUSC cis rs4132509 0.793 rs7522883 chr1:243803022 C/T cg21452805 chr1:244014465 NA 0.62 5.94 0.31 7.28e-9 RR interval (heart rate); LUSC cis rs3087591 0.959 rs2051505 chr17:29699859 C/G cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.02 -0.4 1.81e-14 Hip circumference; LUSC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg05340658 chr4:99064831 C4orf37 -0.68 -11.86 -0.54 2.52e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC cis rs7647973 0.961 rs62259943 chr3:49425167 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.5 -7.43 -0.38 9.2e-13 Menarche (age at onset); LUSC trans rs2243480 1.000 rs2465120 chr7:65620974 C/G cg10756647 chr7:56101905 PSPH 0.84 8.39 0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs9287719 0.935 rs10803723 chr2:10722877 C/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.96e-9 Prostate cancer; LUSC cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg08807101 chr21:30365312 RNF160 0.79 14.71 0.63 4.27e-38 Dental caries; LUSC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg05084668 chr3:125655381 ALG1L -0.47 -6.65 -0.34 1.22e-10 Blood pressure (smoking interaction); LUSC cis rs6500395 1.000 rs7191028 chr16:48626023 T/C cg04672837 chr16:48644449 N4BP1 0.49 7.31 0.37 1.95e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1775715 0.677 rs2799034 chr10:32175896 A/G cg03015672 chr10:32216066 ARHGAP12 0.34 6.12 0.32 2.62e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1028488 0.543 rs9460113 chr6:170627651 G/A cg20370364 chr6:170703943 FAM120B -0.47 -7.05 -0.36 1.02e-11 Interferon alpha levels in systemic lupus erythematosus; LUSC cis rs7000551 0.532 rs4872486 chr8:22256359 G/T cg12081754 chr8:22256438 SLC39A14 0.95 15.11 0.64 1.16e-39 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg14343924 chr8:8086146 FLJ10661 0.4 5.86 0.31 1.13e-8 Mood instability; LUSC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg20203395 chr5:56204925 C5orf35 -0.54 -7.86 -0.39 5.45e-14 Coronary artery disease; LUSC trans rs3857536 0.785 rs6455089 chr6:66944733 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs877282 0.842 rs35117541 chr10:764683 C/T cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC cis rs8067354 0.645 rs2645491 chr17:57877049 C/T cg02344993 chr17:57696989 CLTC 0.48 7.11 0.36 7.3e-12 Hemoglobin concentration; LUSC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg02772935 chr3:125709198 NA -0.47 -6.12 -0.32 2.66e-9 Blood pressure (smoking interaction); LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg07677032 chr17:61819896 STRADA 0.54 9.09 0.45 9.15e-18 Prudent dietary pattern; LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg04944784 chr2:26401820 FAM59B -0.77 -11.41 -0.53 1.12e-25 Gut microbiome composition (summer); LUSC trans rs629535 0.814 rs62513378 chr8:70095788 G/C cg21567404 chr3:27674614 NA -0.98 -16.02 -0.66 3.01e-43 Dupuytren's disease; LUSC cis rs644799 0.540 rs10831419 chr11:95478037 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.53 7.17 0.37 4.89e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg04369109 chr6:150039330 LATS1 -0.55 -8.1 -0.41 1.07e-14 Lung cancer; LUSC cis rs7605827 0.930 rs4668926 chr2:15704944 C/T cg19274914 chr2:15703543 NA 0.46 8.77 0.43 9.41e-17 Educational attainment (years of education); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20656751 chr4:2061512 NAT8L 0.64 9.93 0.48 1.58e-20 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs10805346 0.501 rs4604059 chr4:10115065 C/T cg26043149 chr18:55253948 FECH -0.45 -6.66 -0.34 1.12e-10 Urate levels in overweight individuals;Urate levels in obese individuals; LUSC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.47 7.77 0.39 1e-13 Vitiligo; LUSC cis rs4803468 1.000 rs1043413 chr19:41939297 C/G cg09537434 chr19:41945824 ATP5SL 0.94 16.03 0.66 2.77e-43 Height; LUSC trans rs7618501 0.601 rs2624825 chr3:50154989 G/A cg21659725 chr3:3221576 CRBN -0.62 -10.14 -0.49 3.01e-21 Intelligence (multi-trait analysis); LUSC cis rs9733 0.650 rs3738485 chr1:150552392 C/G cg13175981 chr1:150552382 MCL1 0.53 7.4 0.38 1.09e-12 Tonsillectomy; LUSC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg24011408 chr12:48396354 COL2A1 0.4 5.82 0.3 1.38e-8 Bipolar disorder and schizophrenia; LUSC cis rs425277 0.917 rs262656 chr1:2088754 A/C cg03732007 chr1:2071316 PRKCZ 0.45 7.2 0.37 3.97e-12 Height; LUSC cis rs868036 0.718 rs8030456 chr15:68076856 C/T cg24579218 chr15:68104479 NA -0.36 -6.45 -0.33 4.01e-10 Restless legs syndrome; LUSC cis rs12190007 0.573 rs13202383 chr6:169826544 A/G ch.6.169577133F chr6:169835210 NA -0.39 -5.88 -0.31 9.87e-9 Obesity-related traits; LUSC cis rs698813 0.604 rs768007 chr2:44487486 G/A cg00619915 chr2:44497795 NA -0.53 -7.53 -0.38 4.67e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg02269571 chr22:50332266 NA -0.69 -9.93 -0.48 1.61e-20 Schizophrenia; LUSC cis rs6500395 0.962 rs9921741 chr16:48589896 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.94e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg06850241 chr22:41845214 NA -0.31 -5.68 -0.3 2.98e-8 Vitiligo; LUSC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg04511125 chr2:88470314 THNSL2 0.96 9.4 0.46 8.76e-19 Plasma clusterin levels; LUSC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg17173187 chr15:85201210 NMB 0.37 6.42 0.33 4.7e-10 Schizophrenia; LUSC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg17294928 chr15:75287854 SCAMP5 -0.71 -9.51 -0.46 3.8e-19 Blood trace element (Zn levels); LUSC cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg00852783 chr1:26633632 UBXN11 0.61 9.44 0.46 6.37e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs11098499 0.955 rs1397608 chr4:120161744 A/G cg24375607 chr4:120327624 NA 0.76 11.59 0.54 2.52e-26 Corneal astigmatism; LUSC cis rs6912958 0.677 rs111990232 chr6:88022240 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.54 7.59 0.38 3.16e-13 Monocyte percentage of white cells; LUSC cis rs826838 0.616 rs11182893 chr12:38627715 C/G cg13010199 chr12:38710504 ALG10B -0.46 -6.83 -0.35 4.05e-11 Heart rate; LUSC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg20701182 chr2:24300061 SF3B14 0.9 11.62 0.54 1.84e-26 Lymphocyte counts; LUSC trans rs4843747 0.573 rs7499959 chr16:88110422 C/G cg26811252 chr16:29126840 RRN3P2 0.49 8.39 0.42 1.35e-15 Menopause (age at onset); LUSC cis rs6457821 1.000 rs73415612 chr6:35437650 A/G cg06087101 chr6:35551932 FKBP5 0.63 5.79 0.3 1.63e-8 Height; LUSC cis rs9467773 1.000 rs1321481 chr6:26538210 A/T cg11502198 chr6:26597334 ABT1 0.59 9.37 0.46 1.15e-18 Intelligence (multi-trait analysis); LUSC cis rs2180341 0.574 rs13192350 chr6:127677762 G/T cg24812749 chr6:127587940 RNF146 0.64 9.52 0.46 3.74e-19 Breast cancer; LUSC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg22875332 chr1:76189707 ACADM -0.77 -10.39 -0.49 4.35e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2760061 0.603 rs697761 chr1:228192397 G/A cg02753203 chr1:228287806 NA 0.98 19.14 0.72 1.17e-55 Diastolic blood pressure; LUSC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg08219700 chr8:58056026 NA 0.65 8.54 0.42 4.74e-16 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg14584255 chr6:163149320 PACRG;PARK2 -0.33 -6.3 -0.33 9.63e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6939532 0.597 rs2273558 chr6:26466035 A/C cg09904177 chr6:26538194 HMGN4 -0.5 -7.22 -0.37 3.54e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg26441486 chr22:50317300 CRELD2 0.44 6.71 0.34 8.46e-11 Schizophrenia; LUSC cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg26384229 chr12:38710491 ALG10B 0.86 14.7 0.63 4.43e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs2976388 0.647 rs2585174 chr8:143782044 A/G cg17252645 chr8:143867129 LY6D 0.38 6.49 0.33 3.03e-10 Urinary tract infection frequency; LUSC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg14552801 chr7:65878734 NA 0.38 5.91 0.31 8.41e-9 Aortic root size; LUSC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs4631830 0.540 rs2843562 chr10:51496796 A/G cg20129853 chr10:51489980 NA 0.37 8.07 0.4 1.27e-14 Prostate-specific antigen levels; LUSC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg20849893 chr7:64541193 NA -0.67 -5.78 -0.3 1.71e-8 Diabetic kidney disease; LUSC cis rs240764 0.717 rs13208757 chr6:101175014 C/T cg09795085 chr6:101329169 ASCC3 -0.41 -5.75 -0.3 2.02e-8 Neuroticism; LUSC cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.37 -5.85 -0.3 1.16e-8 IgG glycosylation; LUSC cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg06064525 chr11:970664 AP2A2 -0.49 -10.8 -0.51 1.61e-23 Alzheimer's disease (late onset); LUSC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg07701084 chr6:150067640 NUP43 0.53 7.99 0.4 2.25e-14 Lung cancer; LUSC cis rs1775715 0.737 rs55859032 chr10:32213239 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.66 0.34 1.16e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg00071950 chr4:10020882 SLC2A9 0.51 8.56 0.42 4.33e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs5167 0.750 rs3786505 chr19:45490570 A/G cg20090143 chr19:45452003 APOC2 0.34 5.79 0.3 1.6e-8 Blood protein levels; LUSC cis rs72781680 0.898 rs17762651 chr2:24115922 A/G cg08917208 chr2:24149416 ATAD2B 0.87 9.73 0.47 7.07e-20 Lymphocyte counts; LUSC cis rs7937682 0.564 rs7115263 chr11:111379054 C/A cg09085632 chr11:111637200 PPP2R1B 0.5 6.45 0.33 3.86e-10 Primary sclerosing cholangitis; LUSC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg03732007 chr1:2071316 PRKCZ 0.58 10.38 0.49 4.73e-22 Height; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.54 6.96 0.36 1.86e-11 Renal function-related traits (BUN); LUSC cis rs500891 0.505 rs1145910 chr6:84003056 G/A cg08257003 chr6:84140564 ME1 0.32 7.75 0.39 1.08e-13 Platelet-derived growth factor BB levels; LUSC cis rs2795502 1.000 rs1581702 chr10:43344246 G/A cg27426351 chr10:43362370 NA 0.42 5.82 0.3 1.4e-8 Blood protein levels; LUSC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg23281280 chr6:28129359 ZNF389 0.49 6.24 0.32 1.34e-9 Parkinson's disease; LUSC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg15704280 chr7:45808275 SEPT13 -1.02 -19.14 -0.72 1.16e-55 Height; LUSC cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg03354898 chr7:1950403 MAD1L1 -0.32 -6.34 -0.33 7.65e-10 Schizophrenia; LUSC cis rs7647973 0.710 rs11130207 chr3:49611666 T/G cg13072238 chr3:49761600 GMPPB -0.69 -8.19 -0.41 5.44e-15 Menarche (age at onset); LUSC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg03289416 chr15:75166202 SCAMP2 0.45 7.01 0.36 1.34e-11 Breast cancer; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg24101359 chr6:42928495 GNMT -0.39 -6.45 -0.33 3.98e-10 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.27 -0.41 3.15e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.39e-8 Aortic root size; LUSC cis rs12908161 0.683 rs12903256 chr15:85308141 G/T cg17173187 chr15:85201210 NMB 0.36 7.08 0.36 8.5e-12 Schizophrenia; LUSC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg25767906 chr1:53392781 SCP2 0.48 8.69 0.43 1.67e-16 Monocyte count; LUSC cis rs1728785 1.000 rs1645923 chr16:68581051 G/A cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.37e-9 Ulcerative colitis; LUSC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg14773178 chr5:1868261 NA 0.31 5.72 0.3 2.38e-8 Cardiovascular disease risk factors; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10236687 chr16:10626884 EMP2 0.41 6.02 0.31 4.56e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg23711669 chr6:146136114 FBXO30 0.92 18.15 0.7 1.08e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg14343924 chr8:8086146 FLJ10661 0.42 6.08 0.32 3.23e-9 Mood instability; LUSC cis rs6674970 1.000 rs61819219 chr1:151084375 C/G cg11822372 chr1:151115635 SEMA6C 0.54 8.31 0.41 2.51e-15 Childhood ear infection; LUSC cis rs865483 0.895 rs2680718 chr17:35816451 T/C cg06716730 chr17:35851459 DUSP14 0.27 6.04 0.31 4.13e-9 Monocyte count; LUSC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg08048268 chr3:133502702 NA -0.41 -7.41 -0.38 1.07e-12 Iron status biomarkers; LUSC cis rs4474465 0.920 rs7944485 chr11:78225261 T/C cg27205649 chr11:78285834 NARS2 0.51 5.78 0.3 1.67e-8 Alzheimer's disease (survival time); LUSC cis rs6456156 0.586 rs12203510 chr6:167473006 C/T cg25258033 chr6:167368657 RNASET2 0.38 5.86 0.31 1.11e-8 Primary biliary cholangitis; LUSC cis rs477692 0.544 rs12251589 chr10:131417354 C/A cg05714579 chr10:131428358 MGMT -0.77 -12.41 -0.56 2.36e-29 Response to temozolomide; LUSC cis rs17270561 0.636 rs6456698 chr6:25741664 A/C cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs7188861 0.638 rs35342456 chr16:11401503 A/C cg00044050 chr16:11439710 C16orf75 0.61 6.49 0.33 3.06e-10 HDL cholesterol; LUSC trans rs747782 0.528 rs10838881 chr11:48387275 T/C cg03929089 chr4:120376271 NA 0.64 5.98 0.31 5.65e-9 Intraocular pressure; LUSC cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg19508488 chr2:152266495 RIF1 -0.53 -7.74 -0.39 1.23e-13 Lung cancer; LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg13560548 chr3:10150139 C3orf24 0.54 7.75 0.39 1.09e-13 Alzheimer's disease; LUSC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg24578937 chr1:2090814 PRKCZ -0.42 -9.06 -0.44 1.09e-17 Height; LUSC cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg09085632 chr11:111637200 PPP2R1B -1.16 -18.16 -0.7 9.79e-52 Primary sclerosing cholangitis; LUSC cis rs72772090 0.539 rs11741100 chr5:96113245 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.69 -7.09 -0.36 7.99e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11098499 0.863 rs7664986 chr4:120429952 A/C cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.72e-25 Corneal astigmatism; LUSC cis rs250677 0.522 rs12523526 chr5:148349107 A/C cg18129178 chr5:148520854 ABLIM3 0.53 7.16 0.36 5.28e-12 Breast cancer; LUSC cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -7.57 -0.38 3.79e-13 Personality dimensions; LUSC cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg23711669 chr6:146136114 FBXO30 0.82 14.39 0.62 7.07e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs6969780 1.000 rs6976129 chr7:27177746 C/T cg26364809 chr7:27145159 NA -0.6 -6.04 -0.31 4.05e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs2219968 0.828 rs12543027 chr8:78887060 T/A cg00738934 chr8:78996279 NA -0.39 -6.95 -0.36 1.93e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6598955 0.543 rs4585968 chr1:26535146 G/A cg12744634 chr1:26560303 CCDC21 0.39 5.84 0.3 1.25e-8 Obesity-related traits; LUSC cis rs11098499 0.954 rs6857105 chr4:120222298 C/G cg24375607 chr4:120327624 NA 0.79 11.56 0.53 3.26e-26 Corneal astigmatism; LUSC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.77 0.35 5.78e-11 Tonsillectomy; LUSC cis rs2439831 1.000 rs689781 chr15:43792097 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs1475911 1.000 rs17114359 chr21:43510437 A/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.46 -7.37 -0.37 1.4e-12 IgG glycosylation; LUSC cis rs243505 0.762 rs734004 chr7:148505460 C/G cg09806900 chr7:148480153 CUL1 0.57 8.52 0.42 5.55e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs2273669 0.667 rs12154092 chr6:109313303 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs12986413 0.935 rs36065733 chr19:2163771 T/G cg09261902 chr19:2140048 AP3D1 0.33 6.18 0.32 1.89e-9 Height; LUSC cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 8.62 0.43 2.7e-16 Colorectal cancer; LUSC trans rs6450176 0.587 rs10471884 chr5:53344135 T/C cg12559925 chr2:235863365 SH3BP4 0.36 5.94 0.31 7.06e-9 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; LUSC cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg22709100 chr7:91322751 NA 0.41 6.0 0.31 5.02e-9 Breast cancer; LUSC cis rs6740322 0.895 rs6710656 chr2:43566941 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -7.31 -0.37 1.96e-12 Coronary artery disease; LUSC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg20933634 chr6:27740509 NA 0.42 6.12 0.32 2.63e-9 Parkinson's disease; LUSC trans rs6502050 0.835 rs8074267 chr17:80158325 A/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.81e-10 Life satisfaction; LUSC cis rs4363385 0.747 rs6684188 chr1:152974285 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.78 -0.39 9.11e-14 Inflammatory skin disease; LUSC cis rs9467773 1.000 rs6922824 chr6:26553815 C/G cg05738196 chr6:26577821 NA -0.8 -15.45 -0.65 5.25e-41 Intelligence (multi-trait analysis); LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg14893161 chr1:205819251 PM20D1 0.85 15.4 0.64 8.18e-41 Menarche (age at onset); LUSC cis rs9648716 0.515 rs62485391 chr7:140666718 C/T cg23214464 chr7:140373596 ADCK2 0.72 6.05 0.31 3.88e-9 Type 2 diabetes; LUSC cis rs11098499 0.535 rs10005542 chr4:120268302 T/C cg24375607 chr4:120327624 NA 0.69 10.99 0.52 3.39e-24 Corneal astigmatism; LUSC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.06 0.36 9.49e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6012953 1.000 rs6020559 chr20:49118631 A/G cg13958625 chr20:49123093 NA 0.31 6.57 0.34 1.88e-10 Vitiligo; LUSC cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg05347473 chr6:146136440 FBXO30 -0.5 -8.48 -0.42 7.57e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg00031303 chr3:195681400 NA 0.69 9.92 0.48 1.72e-20 Pancreatic cancer; LUSC cis rs3806843 1.000 rs2879089 chr5:140191893 A/T cg26395211 chr5:140044315 WDR55 -0.38 -5.85 -0.3 1.15e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.05 -0.31 3.89e-9 Platelet count; LUSC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg09323728 chr8:95962352 TP53INP1 -0.41 -8.55 -0.42 4.44e-16 Type 2 diabetes; LUSC cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs6964587 0.626 rs4729014 chr7:91550707 A/G cg17063962 chr7:91808500 NA -0.56 -9.23 -0.45 3.27e-18 Breast cancer; LUSC cis rs1559088 1.000 rs1974783 chr19:33551507 C/G cg03563238 chr19:33554763 RHPN2 -0.41 -6.45 -0.33 3.91e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg12810548 chr4:53579237 SNORA26;KIAA0114 -0.5 -6.31 -0.33 8.92e-10 Height; LUSC cis rs3768617 0.510 rs10797844 chr1:183082067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.85 0.51 1.05e-23 Fuchs's corneal dystrophy; LUSC cis rs929354 0.772 rs4716460 chr7:156970054 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg04871131 chr7:94954202 PON1 -0.38 -6.07 -0.32 3.44e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs68170813 0.652 rs74374590 chr7:107172470 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.45 -5.65 -0.3 3.52e-8 Coronary artery disease; LUSC cis rs3956705 0.762 rs13437980 chr7:32997749 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.47 6.7 0.34 8.79e-11 Red cell distribution width; LUSC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg00933542 chr6:150070202 PCMT1 0.33 6.82 0.35 4.37e-11 Lung cancer; LUSC cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg24642439 chr20:33292090 TP53INP2 0.76 12.14 0.55 2.44e-28 Coronary artery disease; LUSC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg24562669 chr7:97807699 LMTK2 0.35 6.22 0.32 1.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 0.534 rs2636072 chr12:34062386 C/T cg13010199 chr12:38710504 ALG10B 0.54 8.29 0.41 2.88e-15 Morning vs. evening chronotype; LUSC cis rs12410462 0.681 rs6681096 chr1:227609720 G/A cg23173402 chr1:227635558 NA 0.69 7.51 0.38 5.36e-13 Major depressive disorder; LUSC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg06238570 chr21:40685208 BRWD1 -0.58 -9.12 -0.45 7.27e-18 Menarche (age at onset); LUSC cis rs3741151 0.892 rs7105705 chr11:73012319 T/G cg17517138 chr11:73019481 ARHGEF17 0.92 8.39 0.42 1.44e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg00684032 chr4:1343700 KIAA1530 0.38 6.6 0.34 1.62e-10 Obesity-related traits; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg06873352 chr17:61820015 STRADA 0.71 12.73 0.57 1.51e-30 Prudent dietary pattern; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg02597269 chr16:77225049 MON1B 0.42 6.51 0.34 2.81e-10 Metabolite levels (Pyroglutamine); LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg06873352 chr17:61820015 STRADA 0.72 12.79 0.57 9.24e-31 Prudent dietary pattern; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg11494091 chr17:61959527 GH2 0.64 13.71 0.6 2.91e-34 Prudent dietary pattern; LUSC cis rs710216 0.917 rs900834 chr1:43412343 A/G cg22176566 chr1:43424700 SLC2A1 -0.48 -6.08 -0.32 3.34e-9 Red cell distribution width; LUSC cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg03146154 chr1:46216737 IPP -0.58 -8.47 -0.42 7.7e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12220238 1.000 rs7076721 chr10:75996682 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.08 0.36 8.3e-12 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg18110333 chr6:292329 DUSP22 -0.5 -7.15 -0.36 5.62e-12 Menopause (age at onset); LUSC trans rs6030 0.957 rs4656687 chr1:169505158 T/C cg25052156 chr10:123355454 FGFR2 0.32 5.94 0.31 6.99e-9 Uric acid levels; LUSC trans rs1347297 0.526 rs890579 chr2:179263287 C/T cg14011486 chr1:26737247 LIN28 0.38 6.05 0.31 3.79e-9 Alzheimer disease and age of onset; LUSC cis rs6977940 0.730 rs56296737 chr7:2889250 C/T cg19731401 chr7:2775893 GNA12 0.7 7.58 0.38 3.54e-13 White matter integrity; LUSC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg08677398 chr8:58056175 NA 0.52 7.02 0.36 1.23e-11 Developmental language disorder (linguistic errors); LUSC cis rs977987 0.806 rs8054769 chr16:75401113 T/C cg03315344 chr16:75512273 CHST6 0.49 9.33 0.45 1.48e-18 Dupuytren's disease; LUSC cis rs1395 0.778 rs2078616 chr2:27441904 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.42 0.38 9.9e-13 Blood metabolite levels; LUSC cis rs7584330 0.554 rs77180399 chr2:238442951 G/A cg16989719 chr2:238392110 NA -0.48 -6.07 -0.32 3.56e-9 Prostate cancer; LUSC cis rs9399135 0.967 rs9389253 chr6:135329755 T/C cg22676075 chr6:135203613 NA 0.48 7.48 0.38 6.5e-13 Red blood cell count; LUSC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg01448562 chr3:133502909 NA -0.65 -10.47 -0.5 2.34e-22 Iron status biomarkers; LUSC cis rs2294693 0.687 rs4714424 chr6:41012506 T/C cg14769373 chr6:40998127 UNC5CL -0.44 -6.15 -0.32 2.19e-9 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg02951883 chr7:2050386 MAD1L1 -0.52 -9.08 -0.44 9.9e-18 Schizophrenia; LUSC cis rs55883249 1.000 rs55883249 chr2:9741535 C/A cg23886495 chr2:9695866 ADAM17 0.49 5.7 0.3 2.67e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7103648 0.932 rs7104036 chr11:47462140 A/G cg20307385 chr11:47447363 PSMC3 0.99 19.44 0.73 7.79e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs317689 0.819 rs317664 chr12:69704747 C/A cg11871910 chr12:69753446 YEATS4 0.48 6.41 0.33 4.93e-10 Response to diuretic therapy; LUSC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg23630131 chr7:65973040 NA -0.21 -6.0 -0.31 5.21e-9 Aortic root size; LUSC cis rs10979 0.571 rs6909701 chr6:143922918 C/G cg25407410 chr6:143891975 LOC285740 -0.57 -6.87 -0.35 3.17e-11 Hypospadias; LUSC cis rs7246967 0.611 rs73030508 chr19:22826032 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs4700695 0.719 rs27080 chr5:65442271 A/G cg21114390 chr5:65439923 SFRS12 -0.63 -9.02 -0.44 1.47e-17 Facial morphology (factor 19); LUSC cis rs11155671 0.530 rs9383914 chr6:150207234 T/G cg04369109 chr6:150039330 LATS1 -0.4 -5.78 -0.3 1.67e-8 Testicular germ cell tumor; LUSC cis rs2190422 0.651 rs1004245 chr7:103088409 A/C cg04218035 chr7:103086829 SLC26A5 0.31 6.08 0.32 3.21e-9 Morning vs. evening chronotype; LUSC cis rs7568458 0.837 rs12714145 chr2:85787341 C/T cg02493740 chr2:85810744 VAMP5 -0.31 -5.68 -0.3 2.94e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs17767294 0.708 rs6908688 chr6:27886051 A/G cg08851530 chr6:28072375 NA 1.06 6.92 0.35 2.26e-11 Parkinson's disease; LUSC cis rs13385 0.769 rs4913073 chr5:139612854 A/G cg26211634 chr5:139558579 C5orf32 0.46 7.05 0.36 1.04e-11 Atrial fibrillation; LUSC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg20503657 chr10:835505 NA 0.78 9.73 0.47 7.08e-20 Eosinophil percentage of granulocytes; LUSC cis rs17014483 1.000 rs17014483 chr4:89667591 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.65 5.85 0.3 1.18e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.76 0.35 5.99e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg15395560 chr15:45543142 SLC28A2 0.33 5.71 0.3 2.54e-8 Uric acid levels; LUSC cis rs7615952 0.932 rs13321217 chr3:125631771 G/A cg05084668 chr3:125655381 ALG1L -0.75 -11.27 -0.53 3.36e-25 Blood pressure (smoking interaction); LUSC cis rs12410462 0.579 rs78343168 chr1:227621090 G/A cg04117972 chr1:227635322 NA 0.81 8.43 0.42 1.08e-15 Major depressive disorder; LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg22963979 chr7:1858916 MAD1L1 -0.58 -9.03 -0.44 1.39e-17 Bipolar disorder and schizophrenia; LUSC cis rs1577917 1.000 rs4706254 chr6:86602813 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.25 -0.32 1.23e-9 Response to antipsychotic treatment; LUSC cis rs3741151 1.000 rs7129663 chr11:73045129 C/T cg17517138 chr11:73019481 ARHGEF17 1.14 9.67 0.47 1.15e-19 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg22907277 chr7:1156413 C7orf50 0.71 8.13 0.41 8.21e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg13114125 chr14:105738426 BRF1 -0.9 -15.72 -0.65 4.49e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs9648716 0.515 rs62485453 chr7:140681937 G/A cg23214464 chr7:140373596 ADCK2 0.7 5.92 0.31 7.86e-9 Type 2 diabetes; LUSC cis rs4423214 0.592 rs10898234 chr11:71236684 A/G cg05163923 chr11:71159392 DHCR7 -0.65 -6.57 -0.34 1.95e-10 Vitamin D levels; LUSC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.12 -0.36 6.8e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6977660 0.714 rs4721827 chr7:19825655 A/G cg07541023 chr7:19748670 TWISTNB 0.6 6.3 0.33 9.45e-10 Thyroid stimulating hormone; LUSC cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg01579765 chr21:45077557 HSF2BP -0.55 -11.95 -0.55 1.25e-27 Mean corpuscular volume; LUSC cis rs7605827 0.930 rs7587257 chr2:15513256 A/G cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.83e-17 Educational attainment (years of education); LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg00166722 chr3:10149974 C3orf24 0.62 8.47 0.42 8.07e-16 Alzheimer's disease; LUSC cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.54 0.75 3.36e-61 Cognitive ability; LUSC cis rs2074585 0.806 rs8033813 chr15:90999715 A/T cg10434728 chr15:90938212 IQGAP1 0.43 8.72 0.43 1.3e-16 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg02269571 chr22:50332266 NA -0.57 -8.69 -0.43 1.68e-16 Schizophrenia; LUSC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg27494647 chr7:150038898 RARRES2 0.52 7.89 0.4 4.43e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs9341808 0.700 rs12215236 chr6:80975058 A/T cg08355045 chr6:80787529 NA 0.56 9.76 0.47 5.61e-20 Sitting height ratio; LUSC cis rs62400317 0.762 rs17423748 chr6:44943982 T/C cg18551225 chr6:44695536 NA -0.45 -7.27 -0.37 2.53e-12 Total body bone mineral density; LUSC cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -10.2 -0.49 1.9e-21 Chronic sinus infection; LUSC cis rs9487051 0.738 rs449850 chr6:109525045 A/G cg01475377 chr6:109611718 NA -0.35 -5.9 -0.31 9.15e-9 Reticulocyte fraction of red cells; LUSC cis rs12791968 0.527 rs12285862 chr11:45014326 T/G cg11846598 chr11:44996168 LOC221122 -0.58 -6.86 -0.35 3.35e-11 Inhibitory control; LUSC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg21521518 chr4:53727714 RASL11B 0.46 6.1 0.32 2.99e-9 Optic nerve measurement (cup area); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21131493 chr3:12923969 NA 0.42 6.15 0.32 2.18e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6545883 0.783 rs7579651 chr2:61800279 C/G cg15711740 chr2:61764176 XPO1 -0.47 -7.54 -0.38 4.35e-13 Tuberculosis; LUSC cis rs2063714 0.658 rs12196864 chr6:157212862 C/T cg23222435 chr6:157204239 ARID1B -0.56 -9.02 -0.44 1.56e-17 Sitting height ratio; LUSC trans rs7824557 0.564 rs12547100 chr8:11242632 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.38 -0.33 5.75e-10 Retinal vascular caliber; LUSC cis rs72781680 0.898 rs17762609 chr2:24114729 G/T cg20701182 chr2:24300061 SF3B14 0.55 5.83 0.3 1.32e-8 Lymphocyte counts; LUSC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC cis rs921968 0.541 rs3770213 chr2:219508372 A/T cg02176678 chr2:219576539 TTLL4 -0.75 -14.57 -0.62 1.41e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs17767294 0.708 rs72848755 chr6:27878553 T/C cg08851530 chr6:28072375 NA 1.31 8.29 0.41 2.8e-15 Parkinson's disease; LUSC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg11247378 chr22:39784982 NA 0.63 12.48 0.56 1.37e-29 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.28 -0.32 1.06e-9 Extrinsic epigenetic age acceleration; LUSC cis rs79349575 0.783 rs17708633 chr17:47011620 C/G cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.72e-12 Type 2 diabetes; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg11235426 chr6:292522 DUSP22 -0.46 -6.9 -0.35 2.64e-11 Menopause (age at onset); LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg11843238 chr5:131593191 PDLIM4 0.42 7.04 0.36 1.09e-11 Breast cancer; LUSC cis rs2227564 0.700 rs12413039 chr10:75524759 C/G cg23231163 chr10:75533350 FUT11 0.49 6.85 0.35 3.64e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs734999 0.588 rs2843402 chr1:2528682 T/C cg18932078 chr1:2524107 MMEL1 -0.32 -7.13 -0.36 6.29e-12 Ulcerative colitis; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.51 -8.73 -0.43 1.28e-16 Prudent dietary pattern; LUSC cis rs7677751 0.806 rs7678144 chr4:55102425 T/C cg17187183 chr4:55093834 PDGFRA 0.39 5.87 0.31 1.06e-8 Corneal astigmatism; LUSC cis rs713477 0.967 rs6573028 chr14:55913397 C/T cg13175173 chr14:55914753 NA -0.3 -6.41 -0.33 4.98e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg05585544 chr11:47624801 NA 0.41 7.02 0.36 1.24e-11 Subjective well-being; LUSC cis rs9549367 0.826 rs2287249 chr13:113889355 A/G cg18105134 chr13:113819100 PROZ -0.67 -9.42 -0.46 7.94e-19 Platelet distribution width; LUSC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg05585544 chr11:47624801 NA 0.4 7.02 0.36 1.27e-11 Subjective well-being; LUSC trans rs9409565 0.717 rs61470662 chr9:97189472 T/C cg05679027 chr9:99775184 HIATL2 -0.49 -7.07 -0.36 9.26e-12 Colorectal cancer (alcohol consumption interaction); LUSC cis rs12900413 0.687 rs11629590 chr15:90304644 A/G cg24249390 chr15:90295951 MESP1 0.38 6.04 0.31 4.19e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9467773 0.595 rs2237236 chr6:26451553 A/G cg09904177 chr6:26538194 HMGN4 -0.59 -8.96 -0.44 2.27e-17 Intelligence (multi-trait analysis); LUSC cis rs8014204 0.587 rs6574201 chr14:75387256 T/C cg08847533 chr14:75593920 NEK9 -0.49 -7.16 -0.36 5.32e-12 Caffeine consumption; LUSC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg24881330 chr22:46731750 TRMU 0.91 7.03 0.36 1.15e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg18876405 chr7:65276391 NA 0.6 9.73 0.47 7.17e-20 Aortic root size; LUSC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg21918786 chr6:109611834 NA -0.38 -6.46 -0.33 3.69e-10 Reticulocyte fraction of red cells; LUSC cis rs68170813 0.559 rs2299422 chr7:106959832 A/T cg02696742 chr7:106810147 HBP1 -0.62 -9.36 -0.46 1.19e-18 Coronary artery disease; LUSC cis rs7528684 0.546 rs11264794 chr1:157647789 A/C cg18268488 chr1:157545234 FCRL4 -0.29 -5.68 -0.3 2.87e-8 Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes; LUSC trans rs4332037 0.851 rs34040190 chr7:1920356 G/A cg11693508 chr17:37793320 STARD3 0.7 7.89 0.4 4.28e-14 Bipolar disorder; LUSC cis rs8005677 1.000 rs4982710 chr14:23398902 C/T cg00579484 chr14:23475993 C14orf93 0.39 5.77 0.3 1.85e-8 Cognitive ability (multi-trait analysis); LUSC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg13298116 chr11:62369859 EML3;MTA2 -0.52 -7.82 -0.39 6.92e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs2237234 0.542 rs7755997 chr6:26483048 G/A cg05738196 chr6:26577821 NA 0.55 8.59 0.43 3.46e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs4343996 0.558 rs11981092 chr7:3412100 C/T cg21248987 chr7:3385318 SDK1 0.35 5.9 0.31 8.73e-9 Motion sickness; LUSC cis rs1847202 1.000 rs7634188 chr3:72941289 A/G cg25664220 chr3:72788482 NA 0.34 6.35 0.33 6.98e-10 Motion sickness; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18625286 chr20:44717989 NCOA5 -0.44 -6.44 -0.33 4.14e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg04450456 chr4:17643702 FAM184B -0.36 -6.01 -0.31 4.78e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs72960926 0.744 rs55867620 chr6:75038763 G/A cg03266952 chr6:74778945 NA -0.81 -6.81 -0.35 4.63e-11 Metabolite levels (MHPG); LUSC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18099408 chr3:52552593 STAB1 -0.4 -7.14 -0.36 5.82e-12 Bipolar disorder; LUSC cis rs9463078 0.547 rs4449629 chr6:44717808 T/C cg25276700 chr6:44698697 NA 0.31 6.35 0.33 7.05e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs72627509 0.951 rs6554401 chr4:57825336 C/G cg26694713 chr4:57773883 REST 0.48 5.72 0.3 2.32e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1152591 0.811 rs1255986 chr14:64655161 A/G cg21174375 chr14:64681225 SYNE2 -0.31 -5.69 -0.3 2.75e-8 Atrial fibrillation; LUSC cis rs1153858 0.943 rs1145079 chr15:45681761 T/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.32 0.74 2.51e-60 Homoarginine levels; LUSC cis rs617219 0.819 rs1870058 chr5:78593158 C/T cg24856658 chr5:78533917 JMY -0.3 -5.84 -0.3 1.22e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg25792367 chr7:127291747 SND1 -0.48 -7.3 -0.37 2.06e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.81e-30 Motion sickness; LUSC cis rs6840360 0.642 rs7682837 chr4:152427686 C/T cg20465933 chr4:152376761 FAM160A1 0.33 5.85 0.31 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg27432699 chr2:27873401 GPN1 -0.55 -8.17 -0.41 6.52e-15 Total body bone mineral density; LUSC cis rs7582720 1.000 rs72934763 chr2:203758396 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18404041 chr3:52824283 ITIH1 -0.54 -10.3 -0.49 8.79e-22 Electroencephalogram traits; LUSC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg12310025 chr6:25882481 NA -0.57 -9.59 -0.46 2.06e-19 Intelligence (multi-trait analysis); LUSC cis rs6496044 0.963 rs11853972 chr15:86062440 A/G cg13263323 chr15:86062960 AKAP13 -0.37 -5.79 -0.3 1.58e-8 Interstitial lung disease; LUSC cis rs1691799 0.899 rs1168294 chr12:66733988 T/C cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.45e-31 White blood cell count (basophil); LUSC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg09365446 chr1:150670422 GOLPH3L 0.47 6.94 0.36 2.04e-11 Melanoma; LUSC cis rs11677370 0.561 rs10191326 chr2:3827524 G/C cg17052675 chr2:3827356 NA -0.66 -10.92 -0.51 6.22e-24 Type 2 diabetes; LUSC cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.49 -0.38 6.2e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg23711669 chr6:146136114 FBXO30 0.89 17.83 0.7 1.93e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.26 -0.37 2.67e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2108225 1.000 rs2108225 chr7:107453103 G/A cg18560240 chr7:107437656 SLC26A3 -0.38 -5.84 -0.3 1.22e-8 Ulcerative colitis; LUSC cis rs12478296 0.591 rs12719765 chr2:242997202 C/G cg06360820 chr2:242988706 NA -0.65 -8.23 -0.41 4.34e-15 Obesity-related traits; LUSC cis rs4242434 0.819 rs2291230 chr8:22463697 C/G cg03733263 chr8:22462867 KIAA1967 0.87 14.82 0.63 1.47e-38 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg22535103 chr8:58192502 C8orf71 -0.75 -9.55 -0.46 2.95e-19 Developmental language disorder (linguistic errors); LUSC trans rs8072100 0.905 rs11651766 chr17:45574931 G/T cg04995722 chr7:26192034 NFE2L3 -0.39 -6.38 -0.33 6.03e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs71403859 0.502 rs36122765 chr16:71504183 G/C cg08717414 chr16:71523259 ZNF19 -0.75 -8.71 -0.43 1.46e-16 Post bronchodilator FEV1; LUSC cis rs8017423 0.967 rs11627528 chr14:90719697 C/A cg04374321 chr14:90722782 PSMC1 -0.69 -10.69 -0.5 3.86e-23 Mortality in heart failure; LUSC cis rs6496932 0.563 rs2344083 chr15:85897432 T/C cg19183879 chr15:85880815 NA -0.28 -6.65 -0.34 1.17e-10 Central corneal thickness;Corneal structure; LUSC cis rs1784581 0.588 rs9346893 chr6:162417511 C/G cg17173639 chr6:162384350 PARK2 0.56 9.89 0.48 2.07e-20 Itch intensity from mosquito bite; LUSC trans rs7737355 0.947 rs6879005 chr5:130615445 C/T cg07715041 chr7:99302981 CYP3A7 -0.39 -6.14 -0.32 2.3e-9 Life satisfaction; LUSC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg20887711 chr4:1340912 KIAA1530 0.43 6.37 0.33 6.12e-10 Obesity-related traits; LUSC trans rs61931739 0.559 rs4385974 chr12:34313128 G/C cg13010199 chr12:38710504 ALG10B 0.4 6.33 0.33 7.75e-10 Morning vs. evening chronotype; LUSC trans rs8002861 0.664 rs4942247 chr13:44405107 A/G cg12856521 chr11:46389249 DGKZ 0.43 6.33 0.33 7.82e-10 Leprosy; LUSC cis rs7264396 0.563 rs2425081 chr20:34299733 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.62 -0.43 2.78e-16 Total cholesterol levels; LUSC cis rs4481887 0.800 rs28680862 chr1:248515419 T/C cg26353448 chr1:248524236 OR2T4 -0.32 -6.01 -0.31 4.91e-9 Common traits (Other); LUSC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.25e-8 Aortic root size; LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.12e-18 Menopause (age at onset); LUSC trans rs7567288 0.636 rs4440017 chr2:134465710 T/C cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg18758796 chr5:131593413 PDLIM4 0.34 5.78 0.3 1.75e-8 Lung function (FEV1/FVC); LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg07507251 chr3:52567010 NT5DC2 0.33 6.39 0.33 5.47e-10 Intelligence (multi-trait analysis); LUSC cis rs4919694 0.611 rs76695159 chr10:105070837 C/T cg04362960 chr10:104952993 NT5C2 1.04 10.76 0.51 2.18e-23 Arsenic metabolism; LUSC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.59 -8.55 -0.42 4.56e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7640424 0.819 rs162070 chr3:107835448 G/A cg09227934 chr3:107805635 CD47 0.43 6.68 0.34 1.01e-10 Body mass index; LUSC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg26513180 chr16:89883248 FANCA -0.84 -14.39 -0.62 7.55e-37 Vitiligo; LUSC cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs17095355 1.000 rs921351 chr10:111704715 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.79 -0.39 8.71e-14 Biliary atresia; LUSC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.96 0.44 2.3e-17 Age-related macular degeneration (geographic atrophy); LUSC cis rs9650315 0.866 rs7815925 chr8:57200382 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.58 7.28 0.37 2.42e-12 Height; LUSC cis rs2898290 0.622 rs978804 chr8:11343673 C/T cg21775007 chr8:11205619 TDH -0.5 -7.53 -0.38 4.88e-13 Systolic blood pressure; LUSC cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -8.35 -0.42 1.82e-15 Chronic sinus infection; LUSC cis rs970548 0.688 rs2082109 chr10:45931102 T/C cg15590007 chr10:45870220 ALOX5 0.55 6.29 0.33 1.01e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs3764563 1.000 rs1022413 chr19:15741984 G/A cg20725493 chr19:15740067 CYP4F8 -0.64 -6.62 -0.34 1.44e-10 Inflammatory biomarkers; LUSC cis rs4776059 0.798 rs4390542 chr15:52937960 T/C cg24008177 chr15:52972085 KIAA1370 0.36 6.53 0.34 2.42e-10 Schizophrenia; LUSC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.57 7.34 0.37 1.67e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs7084921 0.552 rs12780023 chr10:101874829 C/T cg02250046 chr10:101825185 CPN1 -0.31 -5.85 -0.3 1.16e-8 Bone mineral density; LUSC cis rs9325144 0.600 rs2171405 chr12:38741030 G/T cg13010199 chr12:38710504 ALG10B -0.48 -7.45 -0.38 8.08e-13 Morning vs. evening chronotype; LUSC cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg23711669 chr6:146136114 FBXO30 -0.83 -15.15 -0.64 8.22e-40 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg27094323 chr7:1216898 NA -0.34 -5.8 -0.3 1.5e-8 Longevity;Endometriosis; LUSC cis rs9616064 0.557 rs5767318 chr22:47048792 A/G cg05621596 chr22:47072043 GRAMD4 -0.54 -8.59 -0.43 3.48e-16 Urate levels in obese individuals; LUSC cis rs453301 0.598 rs10104303 chr8:8834528 A/T cg06636001 chr8:8085503 FLJ10661 0.58 8.98 0.44 1.96e-17 Joint mobility (Beighton score); LUSC cis rs7503807 0.905 rs62068345 chr17:78608040 C/T cg09596252 chr17:78655493 RPTOR 0.45 7.68 0.39 1.78e-13 Obesity; LUSC trans rs10028773 0.506 rs12374346 chr4:120281705 G/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Educational attainment; LUSC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.06e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3916 0.911 rs3999408 chr12:121167387 C/T cg27246729 chr12:121163418 ACADS 0.49 7.14 0.36 5.75e-12 Urinary metabolites (H-NMR features); LUSC cis rs2573652 0.963 rs2573649 chr15:100514040 C/G cg09918751 chr15:100517450 ADAMTS17 -0.41 -7.63 -0.39 2.49e-13 Height; LUSC cis rs35000415 0.938 rs35188261 chr7:128683539 G/A cg19972273 chr7:128594194 NA 0.67 6.75 0.35 6.46e-11 Systemic lupus erythematosus; LUSC cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg05347473 chr6:146136440 FBXO30 -0.51 -8.74 -0.43 1.19e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs3820928 0.874 rs4675137 chr2:227883910 G/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.8 -0.39 7.97e-14 Pulmonary function; LUSC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg13395646 chr4:1353034 KIAA1530 -0.6 -9.47 -0.46 5.4e-19 Obesity-related traits; LUSC cis rs7000551 0.675 rs2469758 chr8:22363032 C/T cg12081754 chr8:22256438 SLC39A14 0.41 6.23 0.32 1.39e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg16325326 chr1:53192061 ZYG11B -0.91 -16.89 -0.68 1.11e-46 Monocyte count; LUSC cis rs2224391 0.590 rs2773312 chr6:5251798 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.65 -0.34 1.22e-10 Height; LUSC cis rs61931739 0.517 rs11052977 chr12:34035030 A/C cg06521331 chr12:34319734 NA -0.47 -7.59 -0.38 3.21e-13 Morning vs. evening chronotype; LUSC trans rs7647973 0.588 rs4855848 chr3:49653457 C/T cg21659725 chr3:3221576 CRBN -0.69 -8.35 -0.42 1.83e-15 Menarche (age at onset); LUSC cis rs710216 0.917 rs1681859 chr1:43411829 G/A cg03128534 chr1:43423976 SLC2A1 0.48 6.07 0.32 3.45e-9 Red cell distribution width; LUSC cis rs9902453 1.000 rs9912741 chr17:28359511 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.89 -0.44 3.97e-17 Coffee consumption (cups per day); LUSC cis rs9902453 0.967 rs60176674 chr17:28479854 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.52 7.84 0.39 6.02e-14 Coffee consumption (cups per day); LUSC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.87 -0.31 1.04e-8 Lung cancer; LUSC cis rs2840044 0.963 rs225247 chr17:33944590 T/A cg05299278 chr17:33885742 SLFN14 0.3 6.23 0.32 1.38e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg14552801 chr7:65878734 NA 0.44 6.27 0.32 1.12e-9 Aortic root size; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg00166722 chr3:10149974 C3orf24 0.61 8.61 0.43 2.97e-16 Alzheimer's disease; LUSC cis rs9581857 0.579 rs75326986 chr13:27997758 C/T cg22138327 chr13:27999177 GTF3A 0.82 9.34 0.46 1.37e-18 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg03060546 chr3:49711283 APEH 0.65 6.99 0.36 1.46e-11 Menarche (age at onset); LUSC cis rs56399783 0.901 rs73049362 chr7:2826822 G/A cg14895029 chr7:2775587 GNA12 0.51 6.25 0.32 1.22e-9 Childhood ear infection; LUSC cis rs9479482 1.000 rs13198863 chr6:150350781 T/G cg25797454 chr6:150327115 RAET1K 0.34 7.8 0.39 8.08e-14 Alopecia areata; LUSC cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.07 0.4 1.27e-14 Breast cancer; LUSC cis rs6867032 0.958 rs4246754 chr5:2014776 A/C cg26168224 chr5:2018326 NA 0.72 12.88 0.58 4.37e-31 Gut microbiome composition (winter); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02959429 chr17:27916858 GIT1 -0.42 -6.09 -0.32 3.04e-9 Electrocardiographic conduction measures; LUSC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.68 0.47 1.09e-19 Bipolar disorder; LUSC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg06064525 chr11:970664 AP2A2 -0.49 -10.74 -0.51 2.58e-23 Alzheimer's disease (late onset); LUSC cis rs12681288 0.676 rs6559208 chr8:1018833 A/G cg15309053 chr8:964076 NA 0.39 7.88 0.4 4.68e-14 Schizophrenia; LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg14095795 chr11:129122128 NA -0.31 -5.98 -0.31 5.81e-9 Breast cancer; LUSC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg06494592 chr3:125709126 NA -0.53 -6.08 -0.32 3.31e-9 Blood pressure (smoking interaction); LUSC cis rs77633900 0.614 rs2459363 chr15:76874952 T/C cg21673338 chr15:77095150 SCAPER -0.71 -6.94 -0.36 2.05e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs3858526 0.834 rs7125244 chr11:5980359 T/C cg13902645 chr11:5959945 NA -0.63 -8.73 -0.43 1.2e-16 DNA methylation (variation); LUSC cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg26384229 chr12:38710491 ALG10B 0.85 13.98 0.61 2.76e-35 Drug-induced liver injury (flucloxacillin); LUSC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg16447950 chr5:562315 NA -0.59 -7.08 -0.36 8.54e-12 Lung disease severity in cystic fibrosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26335527 chr1:155100185 EFNA1 -0.4 -6.05 -0.31 3.89e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs9326248 0.581 rs10892048 chr11:116814596 A/G cg20608306 chr11:116969690 SIK3 0.36 6.72 0.35 7.92e-11 Blood protein levels; LUSC trans rs9944715 0.906 rs7241829 chr18:43737111 G/C cg01718231 chr17:29326311 RNF135 0.47 6.49 0.33 3.06e-10 Red cell distribution width;Mean corpuscular volume; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25525087 chr17:17743565 NA -0.4 -6.34 -0.33 7.47e-10 Electrocardiographic conduction measures; LUSC cis rs262150 0.659 rs2730275 chr7:158793397 A/G cg09826364 chr7:158789723 NA -0.4 -6.2 -0.32 1.69e-9 Facial morphology (factor 20); LUSC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg09699651 chr6:150184138 LRP11 0.38 5.75 0.3 2.06e-8 Lung cancer; LUSC cis rs11155671 0.530 rs9969044 chr6:150209204 A/G cg13206674 chr6:150067644 NUP43 0.43 6.44 0.33 4.2e-10 Testicular germ cell tumor; LUSC cis rs34375054 0.738 rs3751181 chr12:125626535 A/G cg25124228 chr12:125621409 AACS -0.48 -7.87 -0.4 4.96e-14 Post bronchodilator FEV1/FVC ratio; LUSC cis rs877282 1.000 rs11253370 chr10:773712 G/A cg17470449 chr10:769945 NA 0.49 6.88 0.35 2.93e-11 Uric acid levels; LUSC cis rs7267979 0.932 rs928121 chr20:25534818 A/G cg08601574 chr20:25228251 PYGB 0.41 6.1 0.32 3e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs79149102 0.579 rs7172065 chr15:75321910 C/T cg17294928 chr15:75287854 SCAMP5 -0.77 -6.46 -0.33 3.62e-10 Lung cancer; LUSC cis rs113835537 0.935 rs57043177 chr11:66423147 A/G cg24851651 chr11:66362959 CCS 0.53 6.54 0.34 2.38e-10 Airway imaging phenotypes; LUSC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg13902645 chr11:5959945 NA -0.52 -7.72 -0.39 1.34e-13 DNA methylation (variation); LUSC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg20573242 chr4:122745356 CCNA2 0.65 9.5 0.46 4.14e-19 Type 2 diabetes; LUSC cis rs12815613 0.621 rs11065360 chr12:121386532 A/G cg02403541 chr12:121454288 C12orf43 -0.44 -6.19 -0.32 1.73e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs72960926 1.000 rs72950596 chr6:74921364 C/T cg03266952 chr6:74778945 NA -0.78 -6.04 -0.31 4.11e-9 Metabolite levels (MHPG); LUSC cis rs4499344 0.960 rs17833075 chr19:33075134 G/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.59 -7.74 -0.39 1.15e-13 Mean platelet volume; LUSC cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg03264133 chr6:25882463 NA -0.51 -9.43 -0.46 7.02e-19 Blood metabolite levels; LUSC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg11494091 chr17:61959527 GH2 0.64 13.45 0.59 3.06e-33 Prudent dietary pattern; LUSC cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC trans rs6762477 0.748 rs11717349 chr3:50223977 C/T cg21659725 chr3:3221576 CRBN -0.49 -7.42 -0.38 9.7e-13 Menarche (age at onset); LUSC cis rs7715806 0.500 rs17649248 chr5:74998426 C/T cg19683494 chr5:74908142 NA 0.56 7.65 0.39 2.21e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.8 0.35 4.77e-11 Tonsillectomy; LUSC cis rs6456156 0.846 rs10946211 chr6:167515489 G/A cg07741184 chr6:167504864 NA -0.33 -5.8 -0.3 1.57e-8 Primary biliary cholangitis; LUSC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg05340658 chr4:99064831 C4orf37 -0.63 -10.78 -0.51 1.91e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs11608355 0.515 rs61941591 chr12:109919965 A/C cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs41271473 0.607 rs6692032 chr1:228853984 G/C cg10167378 chr1:228756711 NA 0.48 6.72 0.35 7.79e-11 Chronic lymphocytic leukemia; LUSC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg09165964 chr15:75287851 SCAMP5 -1.01 -15.09 -0.64 1.37e-39 Blood trace element (Zn levels); LUSC cis rs617219 0.889 rs12519500 chr5:78436905 C/A cg24856658 chr5:78533917 JMY -0.31 -5.7 -0.3 2.69e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.4 -0.38 1.08e-12 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.575 rs907205 chr4:120238664 G/C cg25214090 chr10:38739885 LOC399744 0.43 6.53 0.34 2.42e-10 Corneal astigmatism; LUSC cis rs7674212 0.556 rs13151569 chr4:103942790 A/G cg16532752 chr4:104119610 CENPE -0.43 -5.87 -0.31 1.04e-8 Type 2 diabetes; LUSC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg03354898 chr7:1950403 MAD1L1 -0.33 -6.51 -0.34 2.83e-10 Bipolar disorder and schizophrenia; LUSC cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg19628046 chr18:33552617 C18orf21 0.51 6.17 0.32 1.97e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg09455208 chr3:40491958 NA 0.52 9.33 0.45 1.48e-18 Renal cell carcinoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20807030 chr8:67525572 MYBL1 -0.43 -6.23 -0.32 1.37e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs599083 0.530 rs546803 chr11:68186392 C/T cg01657329 chr11:68192670 LRP5 0.47 6.21 0.32 1.53e-9 Bone mineral density (spine); LUSC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg19318889 chr4:1322082 MAEA 0.8 14.57 0.62 1.48e-37 Longevity; LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg12564285 chr5:131593104 PDLIM4 -0.48 -8.27 -0.41 3.22e-15 Blood metabolite levels; LUSC cis rs826838 0.967 rs11168299 chr12:38902028 G/T cg26384229 chr12:38710491 ALG10B 0.93 17.45 0.69 6.12e-49 Heart rate; LUSC cis rs8060686 0.545 rs8057119 chr16:68268836 C/T cg05110241 chr16:68378359 PRMT7 -0.6 -6.65 -0.34 1.19e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.81 0.75 2.85e-62 Homoarginine levels; LUSC cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg15557168 chr22:42548783 NA 0.35 5.87 0.31 1.03e-8 Cognitive function; LUSC cis rs2070488 0.745 rs7649153 chr3:38467753 T/A cg24069376 chr3:38537580 EXOG 0.36 6.35 0.33 6.89e-10 Electrocardiographic conduction measures; LUSC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.86 -0.51 9.54e-24 Schizophrenia; LUSC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg21385522 chr1:16154831 NA -0.61 -8.99 -0.44 1.84e-17 Dilated cardiomyopathy; LUSC cis rs459571 0.959 rs392134 chr9:136909008 G/A cg01294253 chr9:136912663 BRD3 0.34 5.76 0.3 1.9e-8 Platelet distribution width; LUSC cis rs9398803 0.965 rs9491624 chr6:126679106 A/T cg19875578 chr6:126661172 C6orf173 0.41 6.1 0.32 2.95e-9 Male-pattern baldness; LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg15112475 chr7:1198522 ZFAND2A -0.28 -5.69 -0.3 2.78e-8 Longevity;Endometriosis; LUSC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.03 -0.36 1.15e-11 Total body bone mineral density; LUSC cis rs2067615 0.599 rs12369214 chr12:107198611 G/A cg19260189 chr12:106995001 RFX4 0.22 5.68 0.3 2.89e-8 Heart rate; LUSC cis rs9894429 0.527 rs7405469 chr17:79566596 G/C cg21984481 chr17:79567631 NPLOC4 0.36 5.7 0.3 2.64e-8 Eye color traits; LUSC trans rs4332037 0.539 rs11762545 chr7:2060775 C/T cg25206134 chr2:45395956 NA 0.62 7.23 0.37 3.24e-12 Bipolar disorder; LUSC cis rs9303401 0.661 rs9902820 chr17:56637545 A/C cg12560992 chr17:57184187 TRIM37 0.5 7.58 0.38 3.48e-13 Cognitive test performance; LUSC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg18230493 chr5:56204884 C5orf35 -0.8 -12.34 -0.56 4.25e-29 Initial pursuit acceleration; LUSC cis rs7937682 1.000 rs10789843 chr11:111576158 C/T cg09085632 chr11:111637200 PPP2R1B 1.1 16.8 0.68 2.48e-46 Primary sclerosing cholangitis; LUSC cis rs9420 0.961 rs11604333 chr11:57467035 C/G cg02958346 chr11:57425731 CLP1 -0.44 -6.45 -0.33 4.02e-10 Schizophrenia; LUSC cis rs10197940 0.510 rs7557092 chr2:152423459 T/A cg06191203 chr2:152266755 RIF1 -0.56 -7.07 -0.36 9.05e-12 Lung cancer; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg12432903 chr7:1882776 MAD1L1 -0.41 -6.69 -0.34 9.34e-11 Bipolar disorder and schizophrenia; LUSC cis rs6977660 1.000 rs5017193 chr7:19820103 G/A cg07541023 chr7:19748670 TWISTNB 0.5 5.69 0.3 2.79e-8 Thyroid stimulating hormone; LUSC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg04176532 chr22:50317003 CRELD2 -0.39 -5.66 -0.3 3.3e-8 Schizophrenia; LUSC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg19318889 chr4:1322082 MAEA 0.43 7.0 0.36 1.39e-11 Obesity-related traits; LUSC cis rs3806843 0.518 rs2569191 chr5:140013903 C/T cg19875535 chr5:140030758 IK -0.49 -7.99 -0.4 2.19e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs9921338 0.961 rs9936328 chr16:11438221 T/A cg00044050 chr16:11439710 C16orf75 -0.51 -6.87 -0.35 3.19e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2559856 1.000 rs2695296 chr12:102085487 T/C cg12924262 chr12:102091054 CHPT1 0.43 5.99 0.31 5.47e-9 Blood protein levels; LUSC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg14830002 chr1:247616686 OR2B11 0.49 7.05 0.36 1.05e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs3772130 0.962 rs6791046 chr3:121394707 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.67 9.75 0.47 6.41e-20 Cognitive performance; LUSC cis rs11122272 0.735 rs2486730 chr1:231534987 T/G cg06096015 chr1:231504339 EGLN1 0.56 10.03 0.48 7.06e-21 Hemoglobin concentration; LUSC cis rs7824557 0.806 rs10503418 chr8:11118983 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.99 -0.31 5.52e-9 Retinal vascular caliber; LUSC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.79 0.63 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1801251 1.000 rs1446308 chr2:233639309 T/C cg08000102 chr2:233561755 GIGYF2 0.69 11.44 0.53 8.24e-26 Coronary artery disease; LUSC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg00316803 chr15:76480434 C15orf27 -0.4 -6.96 -0.36 1.83e-11 Blood metabolite levels; LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.04 0.44 1.27e-17 Prudent dietary pattern; LUSC cis rs9527 0.590 rs1935323 chr10:104877035 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.35 -0.33 7.16e-10 Arsenic metabolism; LUSC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.0 -0.36 1.44e-11 Alzheimer's disease (late onset); LUSC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 13.04 0.58 1.06e-31 Hip circumference adjusted for BMI; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg24739457 chr1:205821442 NA 0.42 7.46 0.38 7.38e-13 Menarche (age at onset); LUSC cis rs2050392 0.767 rs10763787 chr10:30700753 G/A cg18806716 chr10:30721971 MAP3K8 0.73 11.61 0.54 2.07e-26 Inflammatory bowel disease; LUSC cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.37 1.18e-12 Glomerular filtration rate (creatinine); LUSC cis rs9329221 0.527 rs4841352 chr8:10327590 A/C cg21775007 chr8:11205619 TDH 0.44 6.14 0.32 2.29e-9 Neuroticism; LUSC cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC trans rs6089829 0.962 rs3746747 chr20:61667631 T/C cg17470723 chr8:74884337 TCEB1 0.52 7.92 0.4 3.66e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.68 0.43 1.76e-16 Prudent dietary pattern; LUSC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.95 -0.4 2.91e-14 Chronic sinus infection; LUSC cis rs2361710 0.668 rs4889830 chr17:78114528 G/A cg09238746 chr17:78121135 EIF4A3 -0.64 -10.05 -0.48 6.22e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg21280719 chr6:42927975 GNMT -0.31 -7.84 -0.39 6.14e-14 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs10221833 0.602 rs355885 chr2:165633939 G/A cg26993132 chr16:89239499 CDH15 0.31 5.97 0.31 6.09e-9 Response to statin therapy; LUSC cis rs11098499 0.954 rs11935596 chr4:120412457 G/C cg09307838 chr4:120376055 NA 0.79 11.8 0.54 4.37e-27 Corneal astigmatism; LUSC cis rs8060686 0.545 rs117751972 chr16:68171968 C/T cg27539214 chr16:67997921 SLC12A4 -0.59 -7.2 -0.37 3.99e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs4595586 0.679 rs11169992 chr12:39317207 C/T cg26384229 chr12:38710491 ALG10B 0.44 6.1 0.32 2.87e-9 Morning vs. evening chronotype; LUSC cis rs7100689 0.754 rs10736339 chr10:82059970 G/C cg00277334 chr10:82204260 NA -0.53 -7.33 -0.37 1.73e-12 Post bronchodilator FEV1; LUSC cis rs2075165 0.870 rs9943105 chr1:156245245 T/C cg20302342 chr1:156215951 PAQR6 0.32 6.09 0.32 3.11e-9 Tonsillectomy; LUSC cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.57 0.38 3.75e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.906 rs2270608 chr8:58194688 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -6.39 -0.33 5.61e-10 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11567041 chr10:12391824 CAMK1D 0.43 6.26 0.32 1.18e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.62 -7.89 -0.4 4.43e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs12908161 0.853 rs11633788 chr15:85305142 T/A cg17173187 chr15:85201210 NMB 0.4 8.0 0.4 2.09e-14 Schizophrenia; LUSC cis rs68170813 0.559 rs77185844 chr7:106812916 A/C cg02696742 chr7:106810147 HBP1 -0.63 -9.25 -0.45 2.77e-18 Coronary artery disease; LUSC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg22907277 chr7:1156413 C7orf50 0.65 7.3 0.37 2.17e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9522267 0.535 rs4644738 chr13:112235995 G/A cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 2.99e-8 Hepatitis; LUSC cis rs6456156 0.586 rs6456154 chr6:167472256 C/T cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Primary biliary cholangitis; LUSC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg20573242 chr4:122745356 CCNA2 0.43 6.65 0.34 1.19e-10 Type 2 diabetes; LUSC cis rs1577917 0.917 rs35283633 chr6:86690787 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.93 -0.35 2.18e-11 Response to antipsychotic treatment; LUSC cis rs1865721 0.958 rs57073257 chr18:73172316 A/G cg26385618 chr18:73139727 C18orf62 -0.47 -7.85 -0.39 5.88e-14 Intelligence; LUSC cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg00677455 chr12:58241039 CTDSP2 0.69 10.46 0.5 2.41e-22 Intelligence (multi-trait analysis); LUSC cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.04 -14.75 -0.63 2.96e-38 Gut microbiome composition (summer); LUSC cis rs9905704 0.918 rs444393 chr17:56709222 A/G cg12560992 chr17:57184187 TRIM37 0.55 7.78 0.39 9.1e-14 Testicular germ cell tumor; LUSC trans rs61931739 0.679 rs10844831 chr12:34311245 G/T cg26384229 chr12:38710491 ALG10B 0.55 8.76 0.43 1e-16 Morning vs. evening chronotype; LUSC cis rs250677 0.522 rs6872701 chr5:148359086 C/G cg18129178 chr5:148520854 ABLIM3 0.52 7.36 0.37 1.41e-12 Breast cancer; LUSC cis rs9811920 0.732 rs793446 chr3:99578114 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -7.35 -0.37 1.5e-12 Axial length; LUSC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg02574844 chr11:5959923 NA -0.45 -6.36 -0.33 6.66e-10 DNA methylation (variation); LUSC cis rs3829109 0.564 rs11145910 chr9:139300494 A/G cg14169450 chr9:139327907 INPP5E 0.42 6.22 0.32 1.46e-9 Peak insulin response;Acute insulin response; LUSC cis rs5753037 0.774 rs140118 chr22:30135806 G/A cg11564601 chr22:30592435 NA 0.34 6.06 0.31 3.61e-9 Type 1 diabetes; LUSC cis rs6547741 0.844 rs55826602 chr2:27863452 A/G cg27432699 chr2:27873401 GPN1 -0.89 -17.87 -0.7 1.36e-50 Oral cavity cancer; LUSC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg06544989 chr22:39130855 UNC84B 0.34 5.71 0.3 2.53e-8 Menopause (age at onset); LUSC cis rs3857536 0.813 rs7768944 chr6:66951088 C/T cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg19418458 chr7:158789849 NA -0.63 -10.4 -0.49 3.97e-22 Facial morphology (factor 20); LUSC cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg10327440 chr1:227177885 CDC42BPA -0.65 -5.84 -0.3 1.21e-8 Major depressive disorder; LUSC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg10556349 chr10:835070 NA 0.55 6.01 0.31 4.98e-9 Eosinophil percentage of granulocytes; LUSC trans rs4650994 0.525 rs10913567 chr1:178511941 A/C cg05059571 chr16:84539110 KIAA1609 -0.45 -8.57 -0.42 3.89e-16 HDL cholesterol levels;HDL cholesterol; LUSC trans rs12510870 0.554 rs4591567 chr4:74208645 G/A cg01940055 chr4:146018582 ANAPC10;ABCE1 0.39 6.39 0.33 5.46e-10 Iris color (b* coordinate); LUSC cis rs9747201 0.962 rs11656153 chr17:80072950 G/A cg18209359 chr17:80159595 CCDC57 0.37 5.93 0.31 7.71e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6541297 0.645 rs2296065 chr1:230301776 G/A cg05784532 chr1:230284198 GALNT2 0.57 6.73 0.35 7.55e-11 Coronary artery disease; LUSC cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg06784218 chr1:46089804 CCDC17 0.5 9.66 0.47 1.24e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6430585 0.583 rs1435577 chr2:136624947 C/G cg07169764 chr2:136633963 MCM6 1.25 19.74 0.73 4.9e-58 Corneal structure; LUSC cis rs6951245 0.572 rs73264010 chr7:1040477 T/C cg24642844 chr7:1081250 C7orf50 -0.69 -6.56 -0.34 2.02e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9486715 0.809 rs9486467 chr6:96971803 C/T cg06623918 chr6:96969491 KIAA0776 0.95 17.57 0.69 2.05e-49 Headache; LUSC cis rs7089973 0.872 rs60820172 chr10:116625891 C/T cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 5.96e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3768617 0.510 rs1413388 chr1:183096694 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg01849466 chr14:104193079 ZFYVE21 -0.56 -8.5 -0.42 6.33e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC trans rs11098499 0.863 rs3822194 chr4:120471648 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.8 0.35 4.94e-11 Corneal astigmatism; LUSC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg23172400 chr8:95962367 TP53INP1 -0.41 -8.19 -0.41 5.55e-15 Type 2 diabetes; LUSC cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.53 -0.57 8.8e-30 Chronic sinus infection; LUSC cis rs11626933 1.000 rs61986782 chr14:90751344 C/T cg14092571 chr14:90743983 NA -0.89 -18.73 -0.72 5.11e-54 Gut microbiota (bacterial taxa); LUSC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg03388025 chr16:89894329 SPIRE2 0.31 6.5 0.34 2.89e-10 Vitiligo; LUSC cis rs9326248 0.559 rs609177 chr11:116770517 A/G cg20608306 chr11:116969690 SIK3 0.37 6.91 0.35 2.5e-11 Blood protein levels; LUSC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.41 5.97 0.31 5.96e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7927592 0.913 rs7127948 chr11:68363062 G/A cg01657329 chr11:68192670 LRP5 -0.4 -5.77 -0.3 1.85e-8 Total body bone mineral density; LUSC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg02951883 chr7:2050386 MAD1L1 0.62 12.22 0.56 1.18e-28 Bipolar disorder and schizophrenia; LUSC cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg12927641 chr6:109611667 NA -0.36 -6.12 -0.32 2.56e-9 Reticulocyte fraction of red cells; LUSC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg04450456 chr4:17643702 FAM184B 0.35 5.87 0.31 1.06e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1507153 0.549 rs699182 chr6:79327328 T/G cg05283184 chr6:79620031 NA 0.39 7.08 0.36 8.31e-12 Sjögren's syndrome; LUSC cis rs2197308 0.626 rs6581156 chr12:37858731 C/A cg13010199 chr12:38710504 ALG10B -0.62 -9.61 -0.47 1.87e-19 Morning vs. evening chronotype; LUSC cis rs10876993 0.928 rs1689594 chr12:58057156 T/C cg15848620 chr12:58087721 OS9 -0.55 -7.87 -0.4 4.88e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs6598955 0.543 rs12125620 chr1:26552238 G/A cg04990556 chr1:26633338 UBXN11 0.86 11.39 0.53 1.3e-25 Obesity-related traits; LUSC cis rs2304069 0.614 rs216140 chr5:149443298 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.39 5.71 0.3 2.56e-8 HIV-1 control; LUSC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg21770322 chr7:97807741 LMTK2 0.39 6.76 0.35 6.01e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs4692589 0.581 rs12646523 chr4:170944698 C/T cg19918862 chr4:170955249 NA 0.38 6.99 0.36 1.54e-11 Anxiety disorder; LUSC cis rs11105298 0.891 rs10858906 chr12:89934474 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.53 -7.21 -0.37 3.73e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Parkinson's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01182386 chr15:75182373 MPI -0.51 -6.73 -0.35 7.48e-11 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.778 rs1109341 chr16:75445605 G/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.53 -0.34 2.45e-10 Dupuytren's disease; LUSC cis rs12893668 0.616 rs58033365 chr14:104030901 T/C cg08213375 chr14:104286397 PPP1R13B 0.38 6.31 0.33 9.06e-10 Reticulocyte count; LUSC cis rs8016982 0.662 rs2288498 chr14:81660710 T/C cg01989461 chr14:81687754 GTF2A1 0.5 6.71 0.34 8.52e-11 Schizophrenia; LUSC cis rs7119 0.717 rs62007350 chr15:77804590 G/A cg27398640 chr15:77910606 LINGO1 -0.29 -6.18 -0.32 1.89e-9 Type 2 diabetes; LUSC cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg13010199 chr12:38710504 ALG10B 0.68 10.46 0.5 2.4e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs362272 0.524 rs881816 chr4:3365366 A/G cg18352616 chr4:3374830 RGS12 0.31 6.15 0.32 2.19e-9 Serum sulfate level; LUSC trans rs9393777 0.720 rs36022097 chr6:26995168 G/A cg06606381 chr12:133084897 FBRSL1 -0.61 -6.44 -0.33 4.28e-10 Intelligence (multi-trait analysis); LUSC trans rs961253 0.501 rs6054183 chr20:6354161 T/C cg17788362 chr6:86352627 SYNCRIP 0.43 6.13 0.32 2.5e-9 Colorectal cancer; LUSC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg08859206 chr1:53392774 SCP2 0.46 7.75 0.39 1.13e-13 Monocyte count; LUSC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg23711669 chr6:146136114 FBXO30 0.86 16.18 0.66 6.9e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg11644478 chr21:40555479 PSMG1 0.95 19.5 0.73 4.4e-57 Cognitive function; LUSC cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg03264133 chr6:25882463 NA -0.34 -5.68 -0.3 2.9e-8 Height; LUSC cis rs6565189 0.865 rs4500746 chr16:30504344 T/C cg17640201 chr16:30407289 ZNF48 0.44 5.74 0.3 2.15e-8 Tonsillectomy; LUSC cis rs12464483 0.524 rs1348898 chr2:30888026 C/A cg07150166 chr2:30669952 LCLAT1 0.53 6.17 0.32 1.93e-9 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs3806843 0.966 rs2563260 chr5:140137867 C/A cg19875535 chr5:140030758 IK -0.49 -7.93 -0.4 3.37e-14 Depressive symptoms (multi-trait analysis); LUSC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg06238570 chr21:40685208 BRWD1 -0.54 -8.54 -0.42 4.65e-16 Menarche (age at onset); LUSC cis rs9325144 0.560 rs11183189 chr12:38683770 T/A cg26384229 chr12:38710491 ALG10B 0.6 9.14 0.45 6.29e-18 Morning vs. evening chronotype; LUSC cis rs9300255 0.602 rs1727306 chr12:123665695 A/G cg05973401 chr12:123451056 ABCB9 0.52 6.43 0.33 4.36e-10 Neutrophil percentage of white cells; LUSC cis rs7681440 0.669 rs7693616 chr4:90792230 G/T cg20003494 chr4:90757398 SNCA 0.37 6.23 0.32 1.43e-9 Dementia with Lewy bodies; LUSC cis rs2354432 0.607 rs6685775 chr1:146744294 A/G cg25205988 chr1:146714368 CHD1L -1.0 -9.35 -0.46 1.26e-18 Mitochondrial DNA levels; LUSC cis rs75920871 0.588 rs4620758 chr11:116945718 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.72 -0.35 7.68e-11 Subjective well-being; LUSC cis rs4268898 0.662 rs35624938 chr2:24576651 T/C cg06627628 chr2:24431161 ITSN2 -0.88 -12.89 -0.58 4.05e-31 Asthma; LUSC cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg13852791 chr20:30311386 BCL2L1 0.85 11.22 0.52 5.05e-25 Mean corpuscular hemoglobin; LUSC cis rs9325144 0.600 rs11183505 chr12:38759110 G/T cg13010199 chr12:38710504 ALG10B -0.49 -7.47 -0.38 7.08e-13 Morning vs. evening chronotype; LUSC cis rs870825 0.616 rs1401361 chr4:185643742 G/C cg04058563 chr4:185651563 MLF1IP 0.85 13.38 0.59 5.28e-33 Blood protein levels; LUSC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg06671706 chr8:8559999 CLDN23 0.5 6.74 0.35 7.09e-11 Obesity-related traits; LUSC cis rs977987 0.931 rs11641430 chr16:75495276 T/C cg04384234 chr16:75411784 CFDP1 -0.48 -7.83 -0.39 6.46e-14 Dupuytren's disease; LUSC cis rs554111 0.656 rs4654893 chr1:21305596 G/C cg01072550 chr1:21505969 NA 0.4 6.19 0.32 1.75e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg03036452 chr22:46663545 TTC38 0.59 5.88 0.31 1e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs6722750 0.818 rs13411753 chr2:64394417 A/G cg22352474 chr2:64371530 PELI1 0.64 10.13 0.48 3.31e-21 Neuroticism; LUSC trans rs7618501 0.602 rs10049087 chr3:50123417 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.59 -0.46 2.08e-19 Intelligence (multi-trait analysis); LUSC cis rs4595586 0.644 rs10437944 chr12:39308786 A/C cg26384229 chr12:38710491 ALG10B 0.46 6.25 0.32 1.24e-9 Morning vs. evening chronotype; LUSC cis rs1160297 0.575 rs6725912 chr2:53097030 A/G cg07782112 chr2:53107842 NA 0.43 7.0 0.36 1.42e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg24503407 chr1:205819492 PM20D1 0.57 9.41 0.46 8.41e-19 Menarche (age at onset); LUSC cis rs75804782 0.641 rs11885523 chr2:239344263 G/A cg18131467 chr2:239335373 ASB1 -0.72 -6.54 -0.34 2.25e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg23172400 chr8:95962367 TP53INP1 -0.39 -8.19 -0.41 5.47e-15 Type 2 diabetes; LUSC cis rs7618501 1.000 rs11709680 chr3:49745188 C/T cg24110177 chr3:50126178 RBM5 0.4 6.45 0.33 3.85e-10 Intelligence (multi-trait analysis); LUSC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg25427524 chr10:38739819 LOC399744 -0.74 -13.8 -0.6 1.41e-34 Extrinsic epigenetic age acceleration; LUSC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg13047869 chr3:10149882 C3orf24 0.65 9.51 0.46 3.98e-19 Alzheimer's disease; LUSC cis rs977987 0.836 rs7200053 chr16:75474618 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.16 -0.36 5.2e-12 Dupuytren's disease; LUSC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg24675658 chr1:53192096 ZYG11B -0.53 -8.33 -0.41 2.18e-15 Monocyte count; LUSC cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg04990556 chr1:26633338 UBXN11 -0.46 -6.1 -0.32 2.91e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs78572108 0.844 rs12475650 chr2:42268956 A/G cg00607755 chr2:42274082 PKDCC 0.35 5.98 0.31 5.72e-9 Total body bone mineral density; LUSC cis rs10740039 0.883 rs1470237 chr10:62413139 C/A cg18175470 chr10:62150864 ANK3 -0.46 -6.81 -0.35 4.43e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.76 -9.61 -0.47 1.85e-19 Gut microbiome composition (summer); LUSC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg04369109 chr6:150039330 LATS1 -0.54 -8.13 -0.41 8.67e-15 Lung cancer; LUSC cis rs208520 0.690 rs207091 chr6:66799847 G/T cg07460842 chr6:66804631 NA -1.14 -18.17 -0.71 8.4e-52 Exhaled nitric oxide output; LUSC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg04141948 chr7:1023156 CYP2W1 0.26 5.67 0.3 3.06e-8 Longevity;Endometriosis; LUSC cis rs1775715 0.707 rs1541262 chr10:32179771 A/G cg04359828 chr10:32216031 ARHGAP12 0.39 6.65 0.34 1.17e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg02187348 chr16:89574699 SPG7 0.56 9.02 0.44 1.47e-17 Multiple myeloma (IgH translocation); LUSC cis rs11971779 0.688 rs1862880 chr7:139020100 T/C cg07862535 chr7:139043722 LUC7L2 0.61 7.31 0.37 1.99e-12 Diisocyanate-induced asthma; LUSC cis rs6543140 0.964 rs2160200 chr2:103033963 G/T cg09003973 chr2:102972529 NA 0.57 7.44 0.38 8.7e-13 Blood protein levels; LUSC cis rs9644630 0.932 rs6991941 chr8:19352377 C/T cg01280390 chr8:19363452 CSGALNACT1 0.37 6.96 0.36 1.84e-11 Oropharynx cancer; LUSC cis rs35146811 0.735 rs2272344 chr7:99786819 C/T cg22906224 chr7:99728672 NA 0.47 6.54 0.34 2.36e-10 Coronary artery disease; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg11965913 chr1:205819406 PM20D1 0.96 20.06 0.74 2.79e-59 Menarche (age at onset); LUSC cis rs9473147 0.543 rs4715019 chr6:47447041 T/A cg20196966 chr6:47445060 CD2AP 0.42 5.92 0.31 7.99e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs17401966 1.000 rs12129035 chr1:10291166 G/A cg19773385 chr1:10388646 KIF1B -0.54 -8.42 -0.42 1.11e-15 Hepatocellular carcinoma; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg13560548 chr3:10150139 C3orf24 -0.45 -6.73 -0.35 7.19e-11 Alzheimer's disease; LUSC cis rs12210905 0.925 rs7753123 chr6:26991540 G/C cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.99 -0.31 5.28e-9 Hip circumference adjusted for BMI; LUSC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg24531977 chr5:56204891 C5orf35 -0.66 -9.33 -0.45 1.56e-18 Coronary artery disease; LUSC cis rs7527798 0.545 rs6696228 chr1:207846830 G/A cg09232269 chr1:207846808 CR1L -0.29 -6.26 -0.32 1.16e-9 Erythrocyte sedimentation rate; LUSC trans rs57046232 0.552 rs1887412 chr20:6340856 A/G cg17788362 chr6:86352627 SYNCRIP 0.43 6.09 0.32 3.05e-9 Colorectal cancer; LUSC cis rs10751667 1.000 rs4074232 chr11:977682 C/G ch.11.42038R chr11:967971 AP2A2 0.55 8.32 0.41 2.3e-15 Alzheimer's disease (late onset); LUSC cis rs2985684 1.000 rs2985696 chr14:50094913 C/A cg04989706 chr14:50066350 PPIL5 -0.43 -5.65 -0.3 3.44e-8 Carotid intima media thickness; LUSC trans rs7769051 1.000 rs73554431 chr6:133129922 T/G cg27275811 chr11:74457193 NA -0.64 -6.18 -0.32 1.87e-9 Type 2 diabetes nephropathy; LUSC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg26304593 chr6:42947056 PEX6 0.47 7.09 0.36 8.23e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs422249 0.511 rs102274 chr11:61557826 T/C cg19610905 chr11:61596333 FADS2 -0.55 -8.28 -0.41 2.97e-15 Trans fatty acid levels; LUSC cis rs6740322 0.748 rs1549723 chr2:43460514 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.54 -7.12 -0.36 6.73e-12 Coronary artery disease; LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs3862030 0.720 rs7081110 chr10:104231651 A/G cg05855489 chr10:104503620 C10orf26 0.48 7.28 0.37 2.41e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs9329221 0.935 rs6601450 chr8:10243101 G/T cg27411982 chr8:10470053 RP1L1 0.48 7.64 0.39 2.27e-13 Neuroticism; LUSC cis rs61931739 0.513 rs1608908 chr12:33895389 C/A cg06521331 chr12:34319734 NA -0.35 -5.7 -0.3 2.61e-8 Morning vs. evening chronotype; LUSC cis rs1030877 1.000 rs2241797 chr2:105885961 T/C cg02079111 chr2:105885981 TGFBRAP1 0.78 14.96 0.63 4.33e-39 Obesity-related traits; LUSC cis rs17685 0.712 rs60721456 chr7:75743820 T/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.55 -8.28 -0.41 2.98e-15 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs372883 0.648 rs1153292 chr21:30689195 G/T cg08807101 chr21:30365312 RNF160 -0.66 -10.05 -0.48 6.34e-21 Pancreatic cancer; LUSC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15506890 chr2:3487001 NA -0.54 -8.85 -0.44 5.13e-17 Neurofibrillary tangles; LUSC cis rs3857536 0.813 rs7769683 chr6:66946256 G/A cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC trans rs17039065 1.000 rs719786 chr4:109396732 G/A cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.24e-10 Gut microbiome composition (summer); LUSC cis rs427394 0.659 rs274674 chr5:6755460 C/T cg10857441 chr5:6722123 POLS -0.44 -7.97 -0.4 2.61e-14 Menopause (age at onset); LUSC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg06074448 chr4:187884817 NA -0.41 -6.87 -0.35 3.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9788721 0.836 rs17483548 chr15:78730313 G/A cg18825076 chr15:78729989 IREB2 -0.62 -9.99 -0.48 9.8e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs3540 0.512 rs8033818 chr15:91075535 C/T cg10434728 chr15:90938212 IQGAP1 -0.46 -9.48 -0.46 4.96e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs9311676 0.656 rs11130632 chr3:58369324 C/T cg13750441 chr3:58318267 PXK 0.34 6.66 0.34 1.16e-10 Systemic lupus erythematosus; LUSC cis rs9811920 0.809 rs793464 chr3:99626028 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.44 6.6 0.34 1.63e-10 Axial length; LUSC cis rs554111 0.593 rs7540023 chr1:21310092 T/C cg01072550 chr1:21505969 NA 0.41 6.31 0.33 8.82e-10 Facial morphology (factor 17, height of vermillion upper lip); LUSC trans rs11098499 0.532 rs4833624 chr4:120585497 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.07 0.32 3.41e-9 Corneal astigmatism; LUSC cis rs7020830 0.898 rs2047010 chr9:37077947 A/G cg14294708 chr9:37120828 ZCCHC7 1.1 23.97 0.8 1.43e-74 Schizophrenia; LUSC cis rs4948102 0.551 rs4275190 chr7:56104388 C/T cg17215666 chr7:56131930 SUMF2 0.47 6.32 0.33 8.27e-10 Plasma homocysteine levels (post-methionine load test); LUSC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg06627628 chr2:24431161 ITSN2 -0.61 -7.32 -0.37 1.88e-12 Lymphocyte counts; LUSC cis rs3806843 1.000 rs4404730 chr5:140162610 G/A cg19875535 chr5:140030758 IK 0.5 8.23 0.41 4.2e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs6736093 0.966 rs1122970 chr2:112716697 A/C cg12686935 chr2:112915763 FBLN7 -0.36 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg19774624 chr17:42201019 HDAC5 0.49 7.19 0.37 4.25e-12 Total body bone mineral density; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg12794691 chr3:111805077 C3orf52 0.45 6.32 0.33 8.42e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs854765 0.693 rs12941039 chr17:17765655 C/T cg09796270 chr17:17721594 SREBF1 -0.45 -7.96 -0.4 2.72e-14 Total body bone mineral density; LUSC cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg00277334 chr10:82204260 NA -0.95 -20.09 -0.74 2e-59 Post bronchodilator FEV1; LUSC cis rs11690935 0.610 rs59844139 chr2:172731983 C/A cg13550731 chr2:172543902 DYNC1I2 0.55 8.37 0.42 1.57e-15 Schizophrenia; LUSC cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg05347473 chr6:146136440 FBXO30 -0.58 -10.38 -0.49 4.52e-22 Lobe attachment (rater-scored or self-reported); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10070969 chr6:27861007 HIST1H2AM;HIST1H2BO -0.43 -6.41 -0.33 4.93e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg23158103 chr7:148848205 ZNF398 -0.44 -6.64 -0.34 1.26e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg18200150 chr17:30822561 MYO1D 0.44 8.9 0.44 3.59e-17 Schizophrenia; LUSC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg02574844 chr11:5959923 NA -0.4 -6.17 -0.32 1.94e-9 DNA methylation (variation); LUSC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg04865166 chr7:105162814 PUS7 0.53 5.65 0.3 3.42e-8 Bipolar disorder (body mass index interaction); LUSC cis rs950881 1.000 rs950881 chr2:102932512 G/T cg20060108 chr2:102954350 IL1RL1 0.48 6.36 0.33 6.7e-10 Allergy; LUSC cis rs10751667 0.857 rs7481221 chr11:966813 G/C ch.11.42038R chr11:967971 AP2A2 0.43 6.4 0.33 5.39e-10 Alzheimer's disease (late onset); LUSC cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg26587870 chr6:27730563 NA -0.61 -5.79 -0.3 1.62e-8 Breast cancer; LUSC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg11366901 chr6:160182831 ACAT2 0.91 12.25 0.56 9.31e-29 Age-related macular degeneration (geographic atrophy); LUSC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg02551604 chr5:131831745 NA 0.44 7.07 0.36 9.27e-12 Asthma (sex interaction); LUSC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg12923728 chr3:195709715 SDHAP1 -0.78 -12.7 -0.57 2.07e-30 Pancreatic cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02458384 chr16:2021763 TBL3 -0.53 -6.7 -0.34 9.07e-11 Bipolar disorder and schizophrenia; LUSC cis rs4474465 1.000 rs2063726 chr11:78183533 T/C cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs4363385 0.667 rs2050674 chr1:152913356 C/G cg07796016 chr1:152779584 LCE1C 0.44 6.67 0.34 1.06e-10 Inflammatory skin disease; LUSC cis rs9788721 0.934 rs55676755 chr15:78898932 C/G cg18825076 chr15:78729989 IREB2 -0.51 -8.02 -0.4 1.75e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs3741151 0.892 rs11821094 chr11:73061905 C/G cg17517138 chr11:73019481 ARHGEF17 0.85 8.03 0.4 1.63e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs10186029 0.676 rs4673721 chr2:213941643 T/G cg08319019 chr2:214017104 IKZF2 0.55 8.08 0.4 1.23e-14 Systemic sclerosis; LUSC cis rs10089 0.951 rs736969 chr5:127466347 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.99 0.55 8.74e-28 Ileal carcinoids; LUSC cis rs11608355 1.000 rs11066591 chr12:109880523 G/A cg05360138 chr12:110035743 NA 0.45 6.22 0.32 1.49e-9 Neuroticism; LUSC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg25838465 chr1:92012736 NA -0.75 -15.37 -0.64 1.06e-40 Breast cancer; LUSC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg06609049 chr19:2785107 THOP1 1.12 21.67 0.76 1.25e-65 Total cholesterol levels; LUSC cis rs929354 0.772 rs6971896 chr7:156978412 C/T cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.46 -5.75 -0.3 2.02e-8 Schizophrenia; LUSC cis rs807669 0.548 rs5748028 chr22:19172281 G/A cg02655711 chr22:19163373 SLC25A1 0.69 12.9 0.58 3.71e-31 Metabolite levels; LUSC cis rs4450131 1.000 rs4450131 chr10:126383363 C/T cg20435097 chr10:126320824 FAM53B 0.21 5.75 0.3 2.06e-8 White blood cell count (basophil); LUSC cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg20019365 chr2:219134978 PNKD;AAMP -0.49 -7.4 -0.38 1.12e-12 Colorectal cancer; LUSC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg03433033 chr1:76189801 ACADM 0.76 11.67 0.54 1.28e-26 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs5758511 0.773 rs11913631 chr22:42347371 G/T cg12850546 chr22:42539477 CYP2D7P1 -0.47 -5.89 -0.31 9.29e-9 Birth weight; LUSC cis rs981844 1.000 rs2606341 chr4:154658702 T/C cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs7568458 0.811 rs10175792 chr2:85761654 A/G cg02493740 chr2:85810744 VAMP5 -0.36 -6.49 -0.33 3.19e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs12704876 0.509 rs10257162 chr7:96343642 T/C cg03808172 chr7:96339361 SHFM1 0.54 8.19 0.41 5.76e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs734999 0.588 rs6689711 chr1:2531467 T/C cg18854424 chr1:2615690 NA -0.49 -9.78 -0.47 5.1e-20 Ulcerative colitis; LUSC cis rs11039100 0.607 rs968989 chr11:5783420 T/C cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg00024416 chr22:24240387 NA -0.33 -5.77 -0.3 1.8e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.46 0.38 7.36e-13 Bipolar disorder; LUSC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs853679 0.517 rs9393893 chr6:28109262 T/C cg06606381 chr12:133084897 FBRSL1 -0.45 -5.95 -0.31 6.74e-9 Depression; LUSC cis rs3960554 0.808 rs9801125 chr7:75792451 C/T cg17325771 chr7:75508891 RHBDD2 -0.42 -5.9 -0.31 8.88e-9 Eotaxin levels; LUSC cis rs12220238 1.000 rs11000901 chr10:75919971 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.92 0.35 2.36e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg27494647 chr7:150038898 RARRES2 0.56 8.05 0.4 1.44e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs17428076 0.514 rs3821095 chr2:172684006 A/G cg13550731 chr2:172543902 DYNC1I2 -0.41 -6.21 -0.32 1.59e-9 Myopia; LUSC cis rs2377585 0.653 rs6487333 chr12:8848929 A/T cg03761649 chr12:8850719 RIMKLB -0.46 -6.58 -0.34 1.8e-10 Reticulocyte fraction of red cells; LUSC cis rs11209002 1.000 rs11209002 chr1:67590461 C/T cg02640540 chr1:67518911 SLC35D1 -0.61 -6.63 -0.34 1.39e-10 Crohn's disease; LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg22963979 chr7:1858916 MAD1L1 -0.55 -8.39 -0.42 1.43e-15 Bipolar disorder and schizophrenia; LUSC cis rs9837602 1.000 rs13323143 chr3:99811553 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.13 0.32 2.46e-9 Breast cancer; LUSC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg24531977 chr5:56204891 C5orf35 0.85 13.41 0.59 4.35e-33 Initial pursuit acceleration; LUSC cis rs12950390 0.853 rs59513807 chr17:45867925 G/A cg06532163 chr17:45867833 NA 0.37 6.88 0.35 3.04e-11 IgG glycosylation; LUSC cis rs7465272 0.515 rs34087536 chr8:143720876 G/A cg10596483 chr8:143751796 JRK 0.5 6.9 0.35 2.65e-11 Bipolar disorder and schizophrenia; LUSC cis rs4631830 0.832 rs2611513 chr10:51515457 A/G cg20129853 chr10:51489980 NA 0.32 6.6 0.34 1.62e-10 Prostate-specific antigen levels; LUSC cis rs56283067 0.847 rs2128543 chr6:44685552 G/A cg18551225 chr6:44695536 NA -0.49 -8.6 -0.43 3.25e-16 Total body bone mineral density; LUSC cis rs9287719 0.967 rs7563894 chr2:10754649 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.24 -0.37 3.09e-12 Bipolar disorder; LUSC cis rs12997796 0.556 rs35129240 chr2:86929217 G/A cg25203885 chr2:87302643 LOC285074 -0.81 -8.39 -0.42 1.42e-15 Schizophrenia; LUSC cis rs10193935 1.000 rs13399869 chr2:42386041 C/G cg27598129 chr2:42591480 NA -0.59 -8.1 -0.41 1.01e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg21775007 chr8:11205619 TDH -0.47 -6.84 -0.35 3.71e-11 Neuroticism; LUSC cis rs3916 0.794 rs10431386 chr12:121128926 A/G cg27246729 chr12:121163418 ACADS -0.42 -6.21 -0.32 1.55e-9 Urinary metabolites (H-NMR features); LUSC cis rs1451375 0.698 rs11489734 chr7:50635730 A/T cg18232548 chr7:50535776 DDC 0.5 7.67 0.39 1.94e-13 Malaria; LUSC cis rs9283706 0.593 rs10077634 chr5:66303346 G/A cg11590213 chr5:66331682 MAST4 0.39 5.79 0.3 1.64e-8 Coronary artery disease; LUSC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg16414030 chr3:133502952 NA -0.41 -6.47 -0.33 3.45e-10 Iron status biomarkers; LUSC cis rs4363385 0.747 rs1015995 chr1:152976114 G/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.62 0.43 2.69e-16 Schizophrenia; LUSC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg11890956 chr21:40555474 PSMG1 1.03 19.22 0.72 5.92e-56 Cognitive function; LUSC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg16405210 chr4:1374714 KIAA1530 0.51 7.74 0.39 1.23e-13 Obesity-related traits; LUSC cis rs394563 0.591 rs11155641 chr6:149648595 G/A cg03678062 chr6:149772716 ZC3H12D 0.31 6.1 0.32 2.93e-9 Dupuytren's disease; LUSC trans rs7737355 0.812 rs6868007 chr5:130824810 T/C cg19409254 chr13:36431974 MIR548F5;DCLK1 -0.36 -5.97 -0.31 5.99e-9 Life satisfaction; LUSC cis rs9479482 0.967 rs9479478 chr6:150354608 T/G cg25797454 chr6:150327115 RAET1K 0.32 7.36 0.37 1.46e-12 Alopecia areata; LUSC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg09359103 chr1:154839909 KCNN3 0.72 17.19 0.69 6.66e-48 Prostate cancer; LUSC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg27286337 chr10:134555280 INPP5A 0.92 11.96 0.55 1.07e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs78545713 0.649 rs11751062 chr6:26216165 C/T cg23601095 chr6:26197514 HIST1H3D 0.66 5.79 0.3 1.64e-8 Iron status biomarkers (total iron binding capacity); LUSC trans rs2018683 0.707 rs917219 chr7:28975343 A/G cg19402173 chr7:128379420 CALU -0.47 -7.16 -0.36 5.15e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg03289416 chr15:75166202 SCAMP2 0.45 6.76 0.35 6.11e-11 Breast cancer; LUSC trans rs9291683 0.588 rs2240724 chr4:10021290 G/C cg26043149 chr18:55253948 FECH 0.5 7.44 0.38 8.47e-13 Bone mineral density; LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg11335335 chr11:637885 DRD4 -0.33 -6.11 -0.32 2.82e-9 Systemic lupus erythematosus; LUSC cis rs2137920 1.000 rs2244967 chr10:50224766 A/G cg27141751 chr10:50231850 C10orf72 -0.38 -5.89 -0.31 9.32e-9 Migraine with aura; LUSC cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg06028605 chr16:24865363 SLC5A11 -0.5 -8.95 -0.44 2.53e-17 Intelligence (multi-trait analysis); LUSC cis rs7100689 0.646 rs7077712 chr10:82134894 A/G cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.34 0.37 1.62e-12 Motion sickness; LUSC cis rs983392 0.679 rs10736701 chr11:60031476 C/T cg20284999 chr11:59952153 MS4A6A 0.38 6.38 0.33 5.85e-10 Alzheimer's disease (late onset); LUSC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs977987 0.843 rs12928036 chr16:75483132 G/A cg03315344 chr16:75512273 CHST6 0.53 10.39 0.49 4.28e-22 Dupuytren's disease; LUSC cis rs7178572 0.568 rs3743479 chr15:77406396 A/G cg22256960 chr15:77711686 NA 0.5 7.94 0.4 3.15e-14 Type 2 diabetes; LUSC cis rs7188861 0.681 rs12935137 chr16:11422015 T/C cg00044050 chr16:11439710 C16orf75 0.58 6.03 0.31 4.46e-9 HDL cholesterol; LUSC cis rs2522056 1.000 rs2706339 chr5:131800105 G/T cg24060327 chr5:131705240 SLC22A5 0.46 6.17 0.32 1.96e-9 Lymphocyte counts;Fibrinogen; LUSC trans rs853679 0.517 rs56364346 chr6:28050762 T/G cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs6499755 0.896 rs8058278 chr16:55344508 G/A cg02859129 chr16:55357253 IRX6 0.36 6.15 0.32 2.27e-9 Hypospadias; LUSC cis rs9527 0.545 rs7100369 chr10:104956218 C/A cg23093090 chr10:104574429 C10orf26 -0.34 -6.25 -0.32 1.25e-9 Arsenic metabolism; LUSC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg07936489 chr17:37558343 FBXL20 0.71 9.91 0.48 1.88e-20 Glomerular filtration rate (creatinine); LUSC cis rs11229555 0.645 rs11229450 chr11:58201629 G/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs614226 0.935 rs17431717 chr12:120912210 G/A cg27489772 chr12:121021490 NA -0.54 -6.75 -0.35 6.5e-11 Type 1 diabetes nephropathy; LUSC cis rs981844 0.961 rs17299034 chr4:154671396 A/G cg14289246 chr4:154710475 SFRP2 0.51 6.57 0.34 1.98e-10 Response to statins (LDL cholesterol change); LUSC cis rs8044995 0.563 rs73615919 chr16:68398862 C/T cg05110241 chr16:68378359 PRMT7 -0.77 -8.61 -0.43 2.89e-16 Schizophrenia; LUSC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.83 -0.3 1.28e-8 Alzheimer's disease (late onset); LUSC cis rs7246967 0.673 rs57736314 chr19:22880272 T/G cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.68 -0.34 9.79e-11 Monocyte percentage of white cells; LUSC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.63 6.06 0.31 3.58e-9 Cerebrospinal P-tau181p levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00510787 chr6:151772946 C6orf211;RMND1 0.35 6.37 0.33 6.35e-10 Triglycerides; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg09177884 chr7:1199841 ZFAND2A -0.52 -7.09 -0.36 7.9e-12 Longevity;Endometriosis; LUSC cis rs4631830 0.863 rs4935162 chr10:51525699 C/G cg10326726 chr10:51549505 MSMB -0.33 -5.7 -0.3 2.68e-8 Prostate-specific antigen levels; LUSC cis rs7605827 0.930 rs4668448 chr2:15521740 T/C cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.82e-17 Educational attainment (years of education); LUSC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg12963246 chr6:28129442 ZNF389 -0.44 -6.47 -0.33 3.55e-10 Depression; LUSC cis rs12530845 0.945 rs7799891 chr7:135322853 T/C cg23117316 chr7:135346802 PL-5283 -0.57 -9.77 -0.47 5.48e-20 Red blood cell traits; LUSC cis rs9921338 0.961 rs4781055 chr16:11369428 C/T cg00044050 chr16:11439710 C16orf75 -0.51 -6.83 -0.35 4.15e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs3931020 0.688 rs277374 chr1:75200486 G/A cg10128416 chr1:75198403 TYW3;CRYZ -0.63 -8.42 -0.42 1.1e-15 Resistin levels; LUSC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11060661 chr22:24314208 DDT;DDTL -0.48 -7.97 -0.4 2.6e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg21881798 chr11:8931708 C11orf17;ST5 0.66 14.54 0.62 1.9e-37 Hemoglobin concentration; LUSC cis rs1595825 0.636 rs111540926 chr2:198885578 G/A cg10547527 chr2:198650123 BOLL -0.52 -6.3 -0.33 9.56e-10 Ulcerative colitis; LUSC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.89 -0.4 4.34e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs4792901 0.759 rs9915640 chr17:41603882 T/C cg22562494 chr17:41607896 ETV4 -0.31 -5.95 -0.31 6.72e-9 Dupuytren's disease; LUSC cis rs4665809 0.590 rs11126339 chr2:26253223 T/C cg04944784 chr2:26401820 FAM59B -0.58 -7.97 -0.4 2.62e-14 Gut microbiome composition (summer); LUSC cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg23711669 chr6:146136114 FBXO30 0.91 17.88 0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg22709100 chr7:91322751 NA -0.39 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs6669072 0.527 rs34401202 chr1:91269160 A/G cg08895590 chr1:91227319 NA -0.27 -5.82 -0.3 1.41e-8 Cognitive function; LUSC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg17366294 chr4:99064904 C4orf37 0.54 9.41 0.46 8.59e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs67696533 0.636 rs6141741 chr20:31106567 C/T cg13636640 chr20:31349939 DNMT3B 0.48 6.59 0.34 1.67e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg20243544 chr17:37824526 PNMT 0.52 7.41 0.38 1.06e-12 Asthma; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg18765753 chr7:1198926 ZFAND2A -0.61 -11.76 -0.54 5.96e-27 Longevity;Endometriosis; LUSC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg18252515 chr7:66147081 NA -1.22 -13.19 -0.59 2.98e-32 Diabetic kidney disease; LUSC cis rs2267137 0.903 rs2072051 chr22:29755888 C/T cg07256473 chr22:29710276 RASL10A -0.37 -7.14 -0.36 6.02e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg00857998 chr1:205179979 DSTYK 0.64 9.84 0.47 3.12e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg04871131 chr7:94954202 PON1 -0.38 -6.07 -0.31 3.57e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg03790207 chr6:42947109 PEX6 -0.44 -6.75 -0.35 6.73e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg15704280 chr7:45808275 SEPT13 -1.11 -24.8 -0.81 9.96e-78 Height; LUSC cis rs3008870 1.000 rs3008871 chr1:67419089 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.0 -15.94 -0.66 5.94e-43 Lymphocyte percentage of white cells; LUSC cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg26384229 chr12:38710491 ALG10B 0.85 14.55 0.62 1.78e-37 Bladder cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05379947 chr6:35436047 RPL10A -0.39 -6.03 -0.31 4.4e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4665809 0.878 rs6748745 chr2:26364190 C/T cg19249749 chr1:223853145 CAPN8 -0.51 -6.31 -0.33 8.65e-10 Gut microbiome composition (summer); LUSC cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg01689657 chr7:91764605 CYP51A1 -0.32 -5.77 -0.3 1.79e-8 Breast cancer; LUSC trans rs11098499 0.580 rs12509234 chr4:120319434 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.27e-9 Corneal astigmatism; LUSC cis rs9814567 1.000 rs4572812 chr3:134291177 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.863 rs7699064 chr4:120428309 A/G cg25214090 chr10:38739885 LOC399744 -0.5 -7.32 -0.37 1.83e-12 Corneal astigmatism; LUSC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg18240062 chr17:79603768 NPLOC4 0.78 15.06 0.64 1.71e-39 Eye color traits; LUSC cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg11984989 chr7:158649758 WDR60 1.0 17.99 0.7 4.43e-51 Height; LUSC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg22532475 chr10:104410764 TRIM8 0.34 6.69 0.34 9.52e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs3733418 0.929 rs13149062 chr4:165905360 T/G cg08992305 chr4:165878219 TRIM61;C4orf39 -0.51 -5.93 -0.31 7.64e-9 Obesity-related traits; LUSC cis rs35883536 0.647 rs10875312 chr1:101042320 G/C cg06223162 chr1:101003688 GPR88 -0.47 -8.96 -0.44 2.29e-17 Monocyte count; LUSC cis rs11758351 0.929 rs75475698 chr6:26190609 C/G cg23601095 chr6:26197514 HIST1H3D 0.71 7.35 0.37 1.57e-12 Gout;Renal underexcretion gout; LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg01879757 chr17:41196368 BRCA1 -0.45 -6.85 -0.35 3.63e-11 Menopause (age at onset); LUSC cis rs6696846 0.765 rs61822567 chr1:205078725 T/C cg21643547 chr1:205240462 TMCC2 -0.42 -7.65 -0.39 2.17e-13 Red blood cell count; LUSC cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg22903471 chr2:27725779 GCKR -0.38 -6.36 -0.33 6.65e-10 Total body bone mineral density; LUSC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.16 -0.32 2.06e-9 Total body bone mineral density; LUSC cis rs9463078 0.845 rs1023090 chr6:45012381 T/C cg25276700 chr6:44698697 NA -0.28 -5.67 -0.3 3.13e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg27497285 chr9:95432195 IPPK 0.5 6.32 0.33 8.47e-10 Cognitive function;Information processing speed; LUSC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg23711669 chr6:146136114 FBXO30 -0.75 -11.85 -0.54 2.83e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs4595586 0.545 rs1156705 chr12:39372672 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.59e-11 Morning vs. evening chronotype; LUSC cis rs9814567 0.964 rs3856729 chr3:134200925 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -13.69 -0.6 3.72e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg05283184 chr6:79620031 NA -0.58 -11.98 -0.55 9.46e-28 Intelligence (multi-trait analysis); LUSC cis rs6574644 1.000 rs4903980 chr14:81778263 T/C cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs6087990 0.965 rs2424903 chr20:31349315 C/T cg13636640 chr20:31349939 DNMT3B 1.03 23.1 0.78 3.15e-71 Ulcerative colitis; LUSC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg04287289 chr16:89883240 FANCA -0.48 -7.09 -0.36 7.91e-12 Vitiligo; LUSC cis rs7119038 0.818 rs11217032 chr11:118669605 T/A cg19308663 chr11:118741387 NA 0.35 6.29 0.33 1.01e-9 Sjögren's syndrome; LUSC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC cis rs9837602 1.000 rs35844878 chr3:99796626 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -5.96 -0.31 6.33e-9 Breast cancer; LUSC cis rs9314323 1.000 rs9314323 chr8:26243136 A/G cg13160058 chr8:26243215 BNIP3L -0.44 -7.89 -0.4 4.26e-14 Red cell distribution width; LUSC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs12701220 0.689 rs12536282 chr7:1115650 C/T cg26769984 chr7:1090371 C7orf50 0.58 7.24 0.37 3.1e-12 Bronchopulmonary dysplasia; LUSC trans rs208515 0.556 rs12206707 chr6:66697182 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 14.41 0.62 6.07e-37 Exhaled nitric oxide levels; LUSC cis rs12493885 0.769 rs11710560 chr3:153777276 A/G cg17054900 chr3:154042577 DHX36 -0.72 -7.06 -0.36 9.58e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2698530 0.607 rs1019686 chr2:64462122 A/G cg22352474 chr2:64371530 PELI1 -0.45 -5.83 -0.3 1.32e-8 Iron status biomarkers; LUSC cis rs921968 0.541 rs72965126 chr2:219330189 C/T cg02176678 chr2:219576539 TTLL4 -0.74 -14.38 -0.62 8.23e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs7809950 0.768 rs2701678 chr7:107283711 A/G cg23024343 chr7:107201750 COG5 0.56 8.22 0.41 4.55e-15 Coronary artery disease; LUSC cis rs1858037 0.867 rs6727013 chr2:65558375 C/A cg08085232 chr2:65598271 SPRED2 -0.41 -6.17 -0.32 2.01e-9 Rheumatoid arthritis; LUSC cis rs35150201 0.529 rs7806221 chr7:135318779 T/C cg23117316 chr7:135346802 PL-5283 -0.39 -7.23 -0.37 3.42e-12 Plateletcrit;Mean corpuscular hemoglobin;Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25315855 chr11:6440704 APBB1 0.43 5.97 0.31 6.01e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg01475377 chr6:109611718 NA -0.45 -8.21 -0.41 4.87e-15 Reticulocyte fraction of red cells; LUSC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.71 -0.3 2.46e-8 Life satisfaction; LUSC cis rs239198 0.602 rs17672397 chr6:101288160 C/T cg09795085 chr6:101329169 ASCC3 0.43 6.11 0.32 2.78e-9 Menarche (age at onset); LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.69 -0.57 2.24e-30 Platelet count; LUSC cis rs11018904 0.861 rs61903723 chr11:89968246 C/T cg26138821 chr11:89956704 CHORDC1 -0.6 -7.19 -0.37 4.17e-12 Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg14440974 chr22:39074834 NA -0.36 -5.96 -0.31 6.56e-9 Menopause (age at onset); LUSC cis rs870825 0.616 rs9715644 chr4:185632965 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.33 0.59 8.18e-33 Blood protein levels; LUSC cis rs240764 0.717 rs239215 chr6:101147426 A/G cg09795085 chr6:101329169 ASCC3 0.41 5.91 0.31 8.26e-9 Neuroticism; LUSC cis rs6076065 0.748 rs2253834 chr20:23387816 C/T cg11657817 chr20:23433608 CST11 -0.52 -10.52 -0.5 1.53e-22 Facial morphology (factor 15, philtrum width); LUSC cis rs2721195 0.967 rs11777703 chr8:145703508 G/A cg15320075 chr8:145703422 NA -0.65 -10.94 -0.51 5.04e-24 Age at first birth; LUSC cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg04455712 chr21:45112962 RRP1B 0.42 7.91 0.4 3.79e-14 Mean corpuscular volume; LUSC trans rs140364877 1 rs140364877 chr7:1885178 C/T cg24247370 chr13:99142703 STK24 -0.33 -5.98 -0.31 5.85e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs11229555 0.645 rs11229457 chr11:58207203 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7131987 0.903 rs2216853 chr12:29413248 C/G cg09582351 chr12:29534625 ERGIC2 -0.3 -6.25 -0.32 1.28e-9 QT interval; LUSC cis rs6570726 0.875 rs1883407 chr6:145823432 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.78 0.35 5.5e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg06238570 chr21:40685208 BRWD1 -0.53 -8.21 -0.41 4.79e-15 Menarche (age at onset); LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg05025164 chr4:1340916 KIAA1530 0.53 8.41 0.42 1.21e-15 Longevity; LUSC cis rs72627509 0.767 rs6853156 chr4:57774843 C/T cg26694713 chr4:57773883 REST 0.52 6.42 0.33 4.64e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2050392 0.624 rs303435 chr10:30731491 T/C cg25182066 chr10:30743637 MAP3K8 -0.45 -6.36 -0.33 6.48e-10 Inflammatory bowel disease; LUSC cis rs243505 0.660 rs3807450 chr7:148522269 C/A cg09806900 chr7:148480153 CUL1 0.49 6.61 0.34 1.53e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2710642 0.888 rs13418889 chr2:63079775 T/C cg17519650 chr2:63277830 OTX1 0.48 6.61 0.34 1.56e-10 LDL cholesterol levels;LDL cholesterol; LUSC cis rs11098499 0.754 rs1814813 chr4:120258207 G/T cg24375607 chr4:120327624 NA -0.7 -11.24 -0.52 4.41e-25 Corneal astigmatism; LUSC cis rs11098499 0.909 rs79704848 chr4:120309351 T/A cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg10117171 chr1:25599238 RHD 0.4 6.08 0.32 3.29e-9 Erythrocyte sedimentation rate; LUSC cis rs2235544 0.541 rs928442 chr1:54473488 C/G cg25741118 chr1:54482237 LDLRAD1 -0.28 -6.11 -0.32 2.83e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs9796 0.870 rs2927061 chr15:41302219 A/G cg18705301 chr15:41695430 NDUFAF1 -0.43 -7.64 -0.39 2.35e-13 Menopause (age at onset); LUSC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg17385448 chr1:15911702 AGMAT 0.36 6.18 0.32 1.82e-9 Systolic blood pressure; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg00149659 chr3:10157352 C3orf10 0.95 12.63 0.57 3.62e-30 Alzheimer's disease; LUSC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg27165867 chr14:105738592 BRF1 -0.54 -7.81 -0.39 7.62e-14 Mean platelet volume;Platelet distribution width; LUSC trans rs11696501 0.694 rs6094184 chr20:44256575 G/A cg03272292 chr12:48577362 C12orf68 0.49 6.01 0.31 4.83e-9 Brain structure; LUSC cis rs2180341 0.538 rs4392733 chr6:127712603 T/C cg27446573 chr6:127587934 RNF146 0.46 7.14 0.36 5.74e-12 Breast cancer; LUSC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg17294928 chr15:75287854 SCAMP5 0.41 5.88 0.31 1e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs5167 0.583 rs7252480 chr19:45458925 C/T cg25746394 chr19:45450501 APOC2 0.32 5.95 0.31 6.75e-9 Blood protein levels; LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18099408 chr3:52552593 STAB1 -0.36 -6.23 -0.32 1.42e-9 Electroencephalogram traits; LUSC cis rs7223966 1.000 rs7209435 chr17:61712964 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.44 0.38 8.69e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6964587 1.000 rs2285333 chr7:91667692 T/G cg17063962 chr7:91808500 NA 0.6 9.41 0.46 8.58e-19 Breast cancer; LUSC trans rs75804782 0.641 rs11902599 chr2:239348400 C/T cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.41e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg25767906 chr1:53392781 SCP2 -0.34 -5.79 -0.3 1.67e-8 Monocyte count; LUSC cis rs7267979 1.000 rs4813566 chr20:25386465 G/T cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2425143 1.000 rs11699793 chr20:34271574 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.17 -0.32 1.96e-9 Blood protein levels; LUSC cis rs12618769 0.597 rs3754886 chr2:99107677 A/G cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.62 0.47 1.63e-19 Bipolar disorder; LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.3e-11 Monocyte count; LUSC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg10802521 chr3:52805072 NEK4 -0.54 -8.71 -0.43 1.43e-16 Electroencephalogram traits; LUSC cis rs3812831 0.669 rs7327370 chr13:114946858 A/G cg15896084 chr13:114927664 NA 0.37 6.58 0.34 1.86e-10 Schizophrenia; LUSC cis rs9815354 0.812 rs10510729 chr3:41831998 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9359856 0.510 rs2768936 chr6:90441851 A/G cg13799429 chr6:90582589 CASP8AP2 -0.92 -10.78 -0.51 1.92e-23 Bipolar disorder; LUSC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs897984 0.520 rs12928081 chr16:30885159 T/G cg02466173 chr16:30829666 NA 0.52 8.36 0.42 1.67e-15 Dementia with Lewy bodies; LUSC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg02896835 chr1:92012615 NA -0.65 -11.73 -0.54 7.95e-27 Breast cancer; LUSC cis rs57590327 0.503 rs7618973 chr3:81619588 C/T cg07356753 chr3:81810745 GBE1 0.44 6.12 0.32 2.66e-9 Extraversion; LUSC cis rs67460515 0.926 rs13062740 chr3:161024208 G/A cg03342759 chr3:160939853 NMD3 -0.52 -7.52 -0.38 5.14e-13 Parkinson's disease; LUSC cis rs8179 0.620 rs73232029 chr7:92287283 G/C cg15732164 chr7:92237376 CDK6 -0.41 -5.73 -0.3 2.26e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg03395511 chr6:291903 DUSP22 -0.69 -11.5 -0.53 5.32e-26 Menopause (age at onset); LUSC cis rs6977660 0.652 rs10249291 chr7:19844448 C/G cg05791153 chr7:19748676 TWISTNB 0.79 7.36 0.37 1.44e-12 Thyroid stimulating hormone; LUSC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs12497850 1.000 rs12497850 chr3:48748989 G/T cg07636037 chr3:49044803 WDR6 0.94 15.65 0.65 8.63e-42 Parkinson's disease; LUSC cis rs36051895 0.589 rs17492549 chr9:5202830 A/C cg02405213 chr9:5042618 JAK2 -0.55 -8.33 -0.41 2.18e-15 Pediatric autoimmune diseases; LUSC cis rs1729951 0.575 rs1682356 chr3:136692037 T/C cg12473912 chr3:136751656 NA 0.39 6.81 0.35 4.51e-11 Neuroticism; LUSC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg03388025 chr16:89894329 SPIRE2 0.35 7.42 0.38 1e-12 Vitiligo; LUSC cis rs5771069 0.933 rs137848 chr22:50440296 A/G cg27467552 chr22:50353597 PIM3 -0.39 -6.64 -0.34 1.27e-10 Ulcerative colitis; LUSC cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg05985134 chr18:33552581 C18orf21 0.51 6.92 0.35 2.35e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs2599510 0.811 rs2710625 chr2:32822957 G/A cg02381751 chr2:32503542 YIPF4 0.39 5.71 0.3 2.48e-8 Interleukin-18 levels; LUSC cis rs939574 0.790 rs79225383 chr2:220093972 C/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 6.07 0.32 3.4e-9 Platelet distribution width; LUSC cis rs9300255 0.568 rs1790108 chr12:123636841 A/G cg00376283 chr12:123451042 ABCB9 0.67 8.42 0.42 1.1e-15 Neutrophil percentage of white cells; LUSC cis rs10162002 1.000 rs10162002 chr13:24042510 G/A cg00158254 chr13:24040743 NA 0.54 6.08 0.32 3.31e-9 Hypothyroidism; LUSC cis rs11098499 0.955 rs56386062 chr4:120155135 T/C cg09307838 chr4:120376055 NA 0.69 10.01 0.48 8.32e-21 Corneal astigmatism; LUSC cis rs1348850 0.914 rs4893944 chr2:178289357 G/T cg22681709 chr2:178499509 PDE11A -0.47 -8.69 -0.43 1.6e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4474465 1.000 rs11237495 chr11:78155090 A/G cg27205649 chr11:78285834 NARS2 -0.5 -5.94 -0.31 7.09e-9 Alzheimer's disease (survival time); LUSC cis rs7681440 0.904 rs7680761 chr4:90763510 A/T cg20003494 chr4:90757398 SNCA -0.33 -5.71 -0.3 2.5e-8 Dementia with Lewy bodies; LUSC cis rs11864453 0.826 rs6499560 chr16:72147666 G/T cg16558253 chr16:72132732 DHX38 0.41 6.15 0.32 2.26e-9 Fibrinogen levels; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.72 0.43 1.34e-16 Prudent dietary pattern; LUSC cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg03732007 chr1:2071316 PRKCZ 0.56 9.99 0.48 1.01e-20 Height; LUSC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.42 5.71 0.3 2.49e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs17807624 0.780 rs11250152 chr8:11454200 A/C cg21175976 chr8:11421337 BLK -0.35 -5.85 -0.3 1.17e-8 Systemic lupus erythematosus; LUSC trans rs7824557 0.564 rs13268126 chr8:11230574 G/A cg06636001 chr8:8085503 FLJ10661 -0.54 -8.23 -0.41 4.21e-15 Retinal vascular caliber; LUSC cis rs3755132 0.778 rs73915402 chr2:15732238 G/C cg12888861 chr2:15731646 DDX1 0.5 7.15 0.36 5.48e-12 Wilms tumor; LUSC cis rs2439831 0.867 rs2470134 chr15:43849886 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.74 -7.15 -0.36 5.52e-12 Lung cancer in ever smokers; LUSC cis rs2806561 0.704 rs663942 chr1:23522476 G/A cg19743168 chr1:23544995 NA 0.46 9.11 0.45 8.03e-18 Height; LUSC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg26727032 chr16:67993705 SLC12A4 -0.44 -5.88 -0.31 9.9e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9302065 0.681 rs9524902 chr13:95963518 C/T cg26751094 chr13:95954534 ABCC4 -0.44 -7.98 -0.4 2.43e-14 Blood metabolite levels; LUSC cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg06547715 chr2:218990976 CXCR2 0.33 6.41 0.33 5.05e-10 Ulcerative colitis; LUSC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.53 -0.38 4.89e-13 Height; LUSC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg15445000 chr17:37608096 MED1 0.41 6.95 0.36 1.92e-11 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.519 rs13136069 chr4:98819568 C/T cg03676636 chr4:99064102 C4orf37 0.32 6.12 0.32 2.62e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4566357 1.000 rs7567796 chr2:227922109 T/A cg11843606 chr2:227700838 RHBDD1 -0.4 -5.67 -0.3 3.07e-8 Coronary artery disease; LUSC cis rs1448094 0.872 rs7975457 chr12:86410404 C/T cg02569458 chr12:86230093 RASSF9 0.37 6.03 0.31 4.36e-9 Major depressive disorder; LUSC cis rs703842 0.575 rs701006 chr12:58106836 C/T cg18357645 chr12:58087776 OS9 -0.52 -8.17 -0.41 6.36e-15 Multiple sclerosis; LUSC cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg02153584 chr22:29168773 CCDC117 0.59 8.84 0.44 5.63e-17 Lymphocyte counts; LUSC trans rs4295623 0.585 rs34421088 chr8:11589042 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.49 -0.42 6.64e-16 Morning vs. evening chronotype; LUSC cis rs7192380 1.000 rs11075726 chr16:69584523 A/G cg26679644 chr16:69762563 NA 0.34 6.03 0.31 4.25e-9 Sjögren's syndrome; LUSC trans rs853679 0.882 rs9380064 chr6:28143118 A/G cg06606381 chr12:133084897 FBRSL1 -0.66 -7.14 -0.36 5.96e-12 Depression; LUSC cis rs950027 0.620 rs1145093 chr15:45649813 C/A cg21132104 chr15:45694354 SPATA5L1 0.42 6.13 0.32 2.45e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg25072359 chr17:41440525 NA 0.65 9.41 0.46 8.16e-19 Menopause (age at onset); LUSC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg15664640 chr17:80829946 TBCD 0.49 8.75 0.43 1.08e-16 Breast cancer; LUSC cis rs2559856 1.000 rs2695292 chr12:102087290 G/A cg12924262 chr12:102091054 CHPT1 0.43 6.04 0.31 4e-9 Blood protein levels; LUSC cis rs3126085 0.935 rs10888466 chr1:152166223 A/C cg03465714 chr1:152285911 FLG 0.39 5.65 0.3 3.44e-8 Atopic dermatitis; LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.82 0.35 4.17e-11 Platelet count; LUSC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.46 -8.85 -0.44 5.16e-17 Monocyte percentage of white cells; LUSC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg25019033 chr10:957182 NA -0.51 -6.35 -0.33 6.88e-10 Eosinophil percentage of granulocytes; LUSC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg00310523 chr12:86230176 RASSF9 0.49 9.39 0.46 9.64e-19 Major depressive disorder; LUSC cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.41 0.42 1.21e-15 High light scatter reticulocyte count; LUSC cis rs1401999 0.510 rs2293001 chr3:183700211 C/T cg01324343 chr3:183735012 ABCC5 0.49 9.93 0.48 1.59e-20 Anterior chamber depth; LUSC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.06 0.36 9.63e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21659725 chr3:3221576 CRBN -0.58 -8.19 -0.41 5.8e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg01657329 chr11:68192670 LRP5 -0.43 -6.45 -0.33 3.99e-10 Total body bone mineral density; LUSC cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg11366901 chr6:160182831 ACAT2 0.93 12.97 0.58 1.99e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs4629710 0.592 rs13205441 chr6:131575069 G/A cg12606694 chr6:131520996 AKAP7 0.62 9.42 0.46 7.5e-19 Multiple myeloma (IgH translocation); LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg11494091 chr17:61959527 GH2 0.67 14.25 0.61 2.47e-36 Prudent dietary pattern; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg04267008 chr7:1944627 MAD1L1 -0.49 -7.31 -0.37 1.97e-12 Bipolar disorder and schizophrenia; LUSC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg20295408 chr7:1910781 MAD1L1 -0.43 -5.95 -0.31 6.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs7705502 0.926 rs112299234 chr5:173339531 T/C cg18693985 chr5:173351052 CPEB4 -0.37 -5.97 -0.31 5.91e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs6665290 0.901 rs11580229 chr1:227210820 G/A cg10327440 chr1:227177885 CDC42BPA -1.23 -39.49 -0.91 6.94e-128 Myeloid white cell count; LUSC cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC cis rs6542838 0.641 rs4499468 chr2:99475204 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.42 -5.66 -0.3 3.32e-8 Fear of minor pain; LUSC cis rs8048589 0.604 rs11646584 chr16:12207975 G/A cg02910054 chr16:12241554 SNX29 0.47 6.08 0.32 3.2e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs2219968 0.828 rs4077569 chr8:78918381 C/A cg00738934 chr8:78996279 NA -0.4 -7.18 -0.37 4.67e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs1775715 0.870 rs7095322 chr10:32248491 C/T cg03015672 chr10:32216066 ARHGAP12 -0.32 -5.66 -0.3 3.33e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg18301423 chr5:131593218 PDLIM4 0.38 6.2 0.32 1.66e-9 Blood metabolite levels; LUSC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.92 -0.35 2.31e-11 Alzheimer's disease (late onset); LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.35 0.56 3.93e-29 Prudent dietary pattern; LUSC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg15225532 chr3:44803084 KIF15;KIAA1143 0.55 8.6 0.43 3.08e-16 Depressive symptoms; LUSC cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg25233709 chr10:116636983 FAM160B1 0.44 7.9 0.4 3.98e-14 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7246657 0.943 rs713256 chr19:37865365 C/T cg23950597 chr19:37808831 NA -0.61 -7.34 -0.37 1.63e-12 Coronary artery calcification; LUSC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs4664304 0.658 rs2667015 chr2:160868586 T/C cg03641300 chr2:160917029 PLA2R1 -0.36 -6.04 -0.31 4.03e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg06494592 chr3:125709126 NA -0.5 -5.75 -0.3 2.04e-8 Blood pressure (smoking interaction); LUSC cis rs1564271 0.528 rs1980756 chr10:26979371 G/C cg13837822 chr10:26931731 LOC731789 0.45 9.55 0.46 2.98e-19 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; LUSC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg06484146 chr7:12443880 VWDE -0.69 -7.2 -0.37 4.01e-12 Coronary artery disease; LUSC cis rs11018904 0.906 rs7925507 chr11:89940146 T/C cg26138821 chr11:89956704 CHORDC1 -0.58 -6.7 -0.34 8.78e-11 Intelligence (multi-trait analysis); LUSC cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg12935359 chr14:103987150 CKB 0.63 10.49 0.5 1.97e-22 Intelligence (multi-trait analysis); LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg09877947 chr5:131593287 PDLIM4 0.44 6.86 0.35 3.33e-11 Blood metabolite levels; LUSC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg05368731 chr17:41323189 NBR1 0.95 16.07 0.66 1.92e-43 Menopause (age at onset); LUSC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg03676636 chr4:99064102 C4orf37 0.36 7.91 0.4 3.77e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs2836633 0.929 rs11702165 chr21:40035313 C/T cg05519781 chr21:40033154 ERG 0.78 13.57 0.6 1.01e-33 Coronary artery disease; LUSC trans rs3808502 0.647 rs7821302 chr8:11236572 T/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.66e-10 Neuroticism; LUSC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg14895029 chr7:2775587 GNA12 -0.41 -6.23 -0.32 1.4e-9 Height; LUSC cis rs7223966 1.000 rs2854219 chr17:61942682 C/T cg05941027 chr17:61774174 LIMD2 0.22 5.75 0.3 1.98e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs75804782 0.641 rs6715311 chr2:239363321 A/G cg18131467 chr2:239335373 ASB1 -0.68 -6.21 -0.32 1.58e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs9393777 0.588 rs6933213 chr6:26493909 T/C cg12292205 chr6:26970375 C6orf41 -0.62 -7.65 -0.39 2.15e-13 Intelligence (multi-trait analysis); LUSC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg08859206 chr1:53392774 SCP2 -0.42 -6.71 -0.34 8.12e-11 Monocyte count; LUSC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg09365446 chr1:150670422 GOLPH3L 0.55 8.45 0.42 9.42e-16 Tonsillectomy; LUSC cis rs9926296 0.744 rs460984 chr16:89713174 C/T cg01097406 chr16:89675127 NA 0.49 10.15 0.49 2.77e-21 Vitiligo; LUSC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg22907277 chr7:1156413 C7orf50 0.53 5.88 0.31 9.94e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7937682 0.855 rs7109592 chr11:111533105 C/A cg22437258 chr11:111473054 SIK2 0.5 6.79 0.35 4.99e-11 Primary sclerosing cholangitis; LUSC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg14019146 chr3:50243930 SLC38A3 0.36 8.37 0.42 1.6e-15 Body mass index; LUSC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg23649088 chr2:200775458 C2orf69 0.53 7.25 0.37 2.9e-12 Schizophrenia; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg06873352 chr17:61820015 STRADA 0.72 12.86 0.58 4.88e-31 Prudent dietary pattern; LUSC cis rs9388451 0.805 rs1028481 chr6:126106573 G/T cg05901451 chr6:126070800 HEY2 -0.95 -18.47 -0.71 5.31e-53 Brugada syndrome; LUSC cis rs10740039 0.729 rs6479728 chr10:62490801 A/G cg18175470 chr10:62150864 ANK3 0.38 5.94 0.31 7.06e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg25182066 chr10:30743637 MAP3K8 -0.44 -6.64 -0.34 1.24e-10 Inflammatory bowel disease; LUSC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg11905131 chr22:24372483 LOC391322 0.58 9.84 0.47 3.02e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4631830 0.720 rs7090326 chr10:51503375 A/T cg16070123 chr10:51489643 NA -0.53 -8.58 -0.42 3.67e-16 Prostate-specific antigen levels; LUSC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.9 0.31 8.8e-9 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -24.92 -0.81 3.6e-78 Height; LUSC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg09835421 chr16:68378352 PRMT7 -0.56 -6.31 -0.33 8.67e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2637266 0.745 rs2579732 chr10:78442778 T/C cg18941641 chr10:78392320 NA 0.32 5.82 0.3 1.36e-8 Pulmonary function; LUSC cis rs10207060 0.500 rs28540721 chr2:240714045 C/T cg07506560 chr2:240697449 NA 0.43 6.8 0.35 4.88e-11 Obesity-related traits; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.4 -5.99 -0.31 5.44e-9 Hepatitis; LUSC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg04944784 chr2:26401820 FAM59B -0.74 -10.91 -0.51 6.48e-24 Gut microbiome composition (summer); LUSC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg11494091 chr17:61959527 GH2 0.39 6.77 0.35 5.68e-11 Height; LUSC cis rs9814567 0.752 rs1534029 chr3:134330213 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs977987 0.843 rs11641801 chr16:75455448 A/C cg04384234 chr16:75411784 CFDP1 -0.43 -6.97 -0.36 1.65e-11 Dupuytren's disease; LUSC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg15744005 chr10:104629667 AS3MT -0.38 -7.87 -0.4 4.99e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg08754478 chr10:133766260 PPP2R2D -0.62 -7.89 -0.4 4.46e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg08859206 chr1:53392774 SCP2 0.51 8.67 0.43 1.91e-16 Monocyte count; LUSC cis rs10875746 0.903 rs11168386 chr12:48467977 C/T cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg09184832 chr6:79620586 NA 0.42 6.75 0.35 6.5500000000000006e-11 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3806843 0.576 rs246037 chr5:140331846 C/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs6952808 0.789 rs35729895 chr7:1885069 C/T cg11244813 chr1:145039882 PDE4DIP 0.38 6.04 0.31 4.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs765787 0.530 rs2413784 chr15:45530516 A/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.9 -0.44 3.52e-17 Uric acid levels; LUSC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg13770153 chr20:60521292 NA -0.6 -8.19 -0.41 5.59e-15 Body mass index; LUSC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg13319975 chr6:146136371 FBXO30 0.71 11.22 0.52 5.19e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs1808579 0.904 rs1652344 chr18:21128857 T/C cg14672496 chr18:21087552 C18orf8 0.37 6.59 0.34 1.76e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs807669 0.934 rs762523 chr22:19180589 A/G cg02655711 chr22:19163373 SLC25A1 0.91 17.76 0.7 3.8e-50 Metabolite levels; LUSC cis rs11229555 0.645 rs12269745 chr11:58176875 G/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.03 0.44 1.44e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg25456477 chr12:86230367 RASSF9 0.44 7.83 0.39 6.31e-14 Major depressive disorder; LUSC cis rs950169 0.763 rs35372971 chr15:84941795 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 7.88 0.4 4.62e-14 Schizophrenia; LUSC cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg12011299 chr4:100065546 ADH4 0.64 10.08 0.48 5.01e-21 Alcohol dependence; LUSC cis rs11039100 1.000 rs12798822 chr11:5826711 T/C cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9527 0.590 rs7089680 chr10:104802071 C/T cg04362960 chr10:104952993 NT5C2 -0.61 -9.8 -0.47 4.17e-20 Arsenic metabolism; LUSC cis rs9633740 0.685 rs4934284 chr10:82277297 C/G cg01528321 chr10:82214614 TSPAN14 -0.76 -5.96 -0.31 6.47e-9 Post bronchodilator FEV1; LUSC trans rs61931739 0.500 rs3934517 chr12:34451396 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.58 0.6 9.51e-34 Morning vs. evening chronotype; LUSC cis rs7617773 0.780 rs2541 chr3:48339618 A/G cg20734569 chr3:48348370 SPINK8 -0.46 -7.81 -0.39 7.43e-14 Coronary artery disease; LUSC cis rs12681287 0.547 rs4961197 chr8:87512436 T/C cg00550725 chr8:87521180 FAM82B 0.43 5.68 0.3 2.98e-8 Caudate activity during reward; LUSC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg05872129 chr22:39784769 NA -0.61 -11.21 -0.52 5.78e-25 Intelligence (multi-trait analysis); LUSC cis rs240764 0.658 rs11155635 chr6:101199367 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC cis rs9650657 0.504 rs10093053 chr8:11037187 T/C cg21775007 chr8:11205619 TDH -0.54 -7.79 -0.39 8.58e-14 Neuroticism; LUSC cis rs17854409 0.881 rs68091818 chr20:61479882 A/C cg05147244 chr20:61493195 TCFL5 0.88 7.12 0.36 6.74e-12 Obesity-related traits; LUSC trans rs6076960 0.684 rs3844461 chr20:6253115 G/A cg21095983 chr6:86352623 SYNCRIP 0.51 7.89 0.4 4.31e-14 Smooth-surface caries; LUSC trans rs6600671 0.934 rs7528274 chr1:121286901 A/T cg00646200 chr1:148855367 NA 0.5 7.99 0.4 2.25e-14 Hip geometry; LUSC cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg22920501 chr2:26401640 FAM59B 0.83 12.02 0.55 6.49e-28 Gut microbiome composition (summer); LUSC trans rs7681440 0.904 rs58864428 chr4:90766986 T/C cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.0 -0.31 5.12e-9 Dementia with Lewy bodies; LUSC cis rs1784581 0.802 rs6455787 chr6:162411378 G/A cg17173639 chr6:162384350 PARK2 0.67 11.87 0.54 2.37e-27 Itch intensity from mosquito bite; LUSC cis rs11051970 0.636 rs10844198 chr12:32563479 G/T cg24626660 chr12:32551988 NA 0.31 5.66 0.3 3.25e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7246967 0.673 rs34671960 chr19:22948693 G/A cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.05e-8 Bronchopulmonary dysplasia; LUSC cis rs1691799 0.899 rs1168301 chr12:66736771 C/T cg16791601 chr12:66731901 HELB -0.73 -12.34 -0.56 4.61e-29 White blood cell count (basophil); LUSC cis rs10789491 1.000 rs1890473 chr1:47149794 C/T cg15501359 chr1:47185051 KIAA0494 0.8 11.33 0.53 2.14e-25 Response to hepatitis C treatment; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg07167872 chr1:205819463 PM20D1 0.9 17.75 0.7 3.98e-50 Menarche (age at onset); LUSC cis rs72781680 0.898 rs17462558 chr2:24020812 T/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18342900 chr16:46865048 C16orf87 0.42 6.23 0.32 1.4e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs300703 0.719 rs437853 chr2:196973 C/T cg21211680 chr2:198530 NA -0.67 -7.89 -0.4 4.5e-14 Blood protein levels; LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.52 -0.5 1.56e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7577696 0.524 rs805831 chr2:32484228 C/G cg02381751 chr2:32503542 YIPF4 0.51 6.88 0.35 2.95e-11 Inflammatory biomarkers; LUSC trans rs2204008 0.682 rs2320517 chr12:38259239 A/T cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Bladder cancer; LUSC cis rs56399783 0.901 rs73051469 chr7:2877811 A/G cg14895029 chr7:2775587 GNA12 0.52 6.3 0.33 9.29e-10 Childhood ear infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03990565 chr11:64885225 ZNHIT2 -0.42 -6.25 -0.32 1.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7100689 0.646 rs4357632 chr10:82131783 C/T cg00277334 chr10:82204260 NA -0.52 -7.74 -0.39 1.21e-13 Post bronchodilator FEV1; LUSC cis rs9549260 0.753 rs10507486 chr13:41186501 A/G cg21288729 chr13:41239152 FOXO1 -0.54 -6.27 -0.32 1.09e-9 Red blood cell count; LUSC trans rs7937682 0.632 rs7112886 chr11:111743232 T/C cg18187862 chr3:45730750 SACM1L -0.53 -6.43 -0.33 4.3e-10 Primary sclerosing cholangitis; LUSC cis rs561341 0.740 rs11080174 chr17:30208521 C/A cg00745463 chr17:30367425 LRRC37B 0.58 7.3 0.37 2.1e-12 Hip circumference adjusted for BMI; LUSC cis rs2639990 1.000 rs1702831 chr18:72897368 C/A cg03972071 chr18:72917163 ZADH2 0.47 5.76 0.3 1.93e-8 Vascular endothelial growth factor levels; LUSC trans rs4332037 0.624 rs11764124 chr7:1891723 C/G cg11693508 chr17:37793320 STARD3 0.5 6.29 0.33 1e-9 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26917132 chr16:87425759 FBXO31;MAP1LC3B 0.53 7.32 0.37 1.9e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.73 0.54 7.78e-27 Prudent dietary pattern; LUSC cis rs2797160 1.000 rs6910933 chr6:126017155 C/G cg05901451 chr6:126070800 HEY2 0.57 8.59 0.43 3.32e-16 Endometrial cancer; LUSC cis rs2832077 0.943 rs2272701 chr21:30190907 C/T cg24692254 chr21:30365293 RNF160 -0.58 -7.22 -0.37 3.57e-12 Cognitive test performance; LUSC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg06637938 chr14:75390232 RPS6KL1 0.52 8.2 0.41 5.08e-15 Height; LUSC cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg14844989 chr11:31128820 NA 0.39 5.93 0.31 7.53e-9 Red blood cell count; LUSC cis rs7937682 0.889 rs11213969 chr11:111528441 A/G cg19812747 chr11:111475976 SIK2 -0.49 -7.0 -0.36 1.4e-11 Primary sclerosing cholangitis; LUSC cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg02961200 chr2:178257176 LOC100130691;AGPS -0.62 -8.23 -0.41 4.18e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18301423 chr5:131593218 PDLIM4 -0.47 -7.41 -0.38 1.02e-12 Acylcarnitine levels; LUSC cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg16339924 chr4:17578868 LAP3 0.61 9.17 0.45 5.09e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg01884057 chr2:25150051 NA 0.49 11.57 0.54 2.8e-26 Body mass index; LUSC cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg11502198 chr6:26597334 ABT1 -0.61 -9.62 -0.47 1.64e-19 Intelligence (multi-trait analysis); LUSC cis rs72960926 0.744 rs11753898 chr6:74861057 C/T cg03266952 chr6:74778945 NA -0.85 -7.25 -0.37 2.94e-12 Metabolite levels (MHPG); LUSC cis rs7804356 0.953 rs10256250 chr7:26895080 A/T cg03456212 chr7:26904342 SKAP2 -0.52 -6.04 -0.31 4.16e-9 Type 1 diabetes; LUSC cis rs17270561 0.636 rs1575535 chr6:25809909 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 7.86 0.4 5.26e-14 Iron status biomarkers; LUSC cis rs8017423 0.967 rs59980414 chr14:90687738 G/C cg14092571 chr14:90743983 NA -0.36 -5.82 -0.3 1.36e-8 Mortality in heart failure; LUSC cis rs17102423 0.594 rs1256417 chr14:65563678 C/T cg11161011 chr14:65562177 MAX -0.71 -10.76 -0.51 2.24e-23 Obesity-related traits; LUSC cis rs1865760 0.865 rs9467651 chr6:25958257 C/G cg17691542 chr6:26056736 HIST1H1C 0.46 6.9 0.35 2.67e-11 Height; LUSC cis rs1030268 0.577 rs13244007 chr7:133260825 A/G cg10665199 chr7:133106180 EXOC4 0.63 7.12 0.36 6.59e-12 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.09 0.55 3.63e-28 Prudent dietary pattern; LUSC cis rs9463078 0.547 rs9472360 chr6:44747410 T/C cg25276700 chr6:44698697 NA 0.3 6.33 0.33 7.67e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs11645898 0.935 rs72787077 chr16:72156674 C/T cg14768367 chr16:72042858 DHODH -0.64 -7.22 -0.37 3.49e-12 Blood protein levels; LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.56 -8.36 -0.42 1.77e-15 Gut microbiome composition (summer); LUSC cis rs8099014 1.000 rs8099014 chr18:56109859 C/A cg12907477 chr18:56117327 MIR122 0.45 7.21 0.37 3.77e-12 Platelet count; LUSC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs1799949 0.794 rs116409325 chr17:41445460 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.98 0.31 5.73e-9 Menopause (age at onset); LUSC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.09 -0.36 8.12e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1577917 0.655 rs2842605 chr6:86335150 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -5.73 -0.3 2.23e-8 Response to antipsychotic treatment; LUSC cis rs2540226 0.935 rs6722610 chr2:39985742 C/T cg23576258 chr2:39999331 THUMPD2 0.35 5.87 0.31 1.03e-8 Personality dimensions; LUSC cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.92 0.4 3.59e-14 Colorectal cancer; LUSC cis rs11098499 0.863 rs1480940 chr4:120457682 T/C cg24375607 chr4:120327624 NA 0.78 11.42 0.53 1.03e-25 Corneal astigmatism; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg18538332 chr22:24372958 LOC391322 -0.47 -8.31 -0.41 2.41e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4919687 0.550 rs12783444 chr10:104480659 G/A cg05855489 chr10:104503620 C10orf26 0.71 11.5 0.53 5.26e-26 Colorectal cancer; LUSC trans rs2288327 0.557 rs7577862 chr2:179352857 G/A cg14011486 chr1:26737247 LIN28 0.78 9.73 0.47 7.51e-20 Atrial fibrillation; LUSC cis rs8177253 0.633 rs10935073 chr3:133439184 T/C cg08048268 chr3:133502702 NA -0.37 -6.6 -0.34 1.6e-10 Iron status biomarkers; LUSC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs7084921 0.547 rs12780035 chr10:101874844 C/T cg11888571 chr10:102027403 CWF19L1 -0.45 -6.11 -0.32 2.85e-9 Bone mineral density; LUSC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.82 -0.3 1.37e-8 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.954 rs35063680 chr4:120387102 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.2 0.32 1.7e-9 Corneal astigmatism; LUSC cis rs6967385 0.867 rs62451462 chr7:12359234 A/G cg06484146 chr7:12443880 VWDE 0.39 5.76 0.3 1.87e-8 Response to taxane treatment (placlitaxel); LUSC trans rs800082 1.000 rs7613909 chr3:144308606 A/G cg24215973 chr2:240111563 HDAC4 0.42 6.38 0.33 5.79e-10 Smoking behavior; LUSC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg11764359 chr7:65958608 NA 0.81 13.5 0.59 1.91e-33 Aortic root size; LUSC cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.7e-16 Menopause (age at onset); LUSC trans rs6852435 1.000 rs34400328 chr4:175298214 T/A cg23753247 chr11:8615842 STK33 -0.54 -6.14 -0.32 2.36e-9 Response to acetaminophen (hepatotoxicity); LUSC cis rs7980687 0.596 rs1727319 chr12:123701353 T/C cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.84 -0.35 3.89e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs3087591 1.000 rs2107360 chr17:29697901 C/A cg24425628 chr17:29625626 OMG;NF1 -0.59 -8.43 -0.42 1.08e-15 Hip circumference; LUSC cis rs6785206 0.772 rs6439134 chr3:128323504 C/T cg16766828 chr3:128327626 NA -0.71 -7.68 -0.39 1.76e-13 Lymphocyte percentage of white cells; LUSC cis rs7264396 0.563 rs2425100 chr20:34310115 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.61 -0.43 2.97e-16 Total cholesterol levels; LUSC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Parkinson's disease; LUSC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg05855489 chr10:104503620 C10orf26 -0.7 -10.14 -0.49 3.15e-21 Allergic disease (asthma, hay fever or eczema); LUSC trans rs72674100 1.000 rs7695114 chr4:97968711 C/T cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs12474201 0.928 rs12998762 chr2:46938393 A/C cg06386533 chr2:46925753 SOCS5 0.76 11.34 0.53 1.89e-25 Height; LUSC cis rs7267979 0.868 rs6138550 chr20:25223430 C/T cg08601574 chr20:25228251 PYGB 0.49 7.55 0.38 4.23e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6906287 0.647 rs6569013 chr6:118681328 G/T cg21191810 chr6:118973309 C6orf204 -0.38 -6.63 -0.34 1.32e-10 Electrocardiographic conduction measures; LUSC cis rs6906287 0.561 rs2078079 chr6:118705213 G/A cg05564266 chr6:118973597 C6orf204 0.24 5.67 0.3 3.06e-8 Electrocardiographic conduction measures; LUSC cis rs1160297 0.609 rs2356680 chr2:53095313 T/C cg07782112 chr2:53107842 NA 0.45 7.22 0.37 3.65e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs34779708 0.931 rs17591135 chr10:35465190 T/A cg04310649 chr10:35416472 CREM -0.41 -6.36 -0.33 6.52e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg10523679 chr1:76189770 ACADM 0.89 15.73 0.65 4.11e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11785400 0.793 rs4581034 chr8:143736968 G/A cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs1014246 0.813 rs1014245 chr10:118466129 G/A cg14919929 chr10:118506882 NA 0.44 6.82 0.35 4.28e-11 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs10992471 0.603 rs12342019 chr9:95192508 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -7.95 -0.4 2.84e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg08213375 chr14:104286397 PPP1R13B -0.42 -8.07 -0.4 1.25e-14 Schizophrenia; LUSC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg12365402 chr11:9010492 NRIP3 0.41 7.52 0.38 5.13e-13 Hemoglobin concentration; LUSC cis rs2463822 0.764 rs7125402 chr11:62097259 C/T cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg03929089 chr4:120376271 NA 0.8 10.15 0.49 2.92e-21 Coronary artery disease; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg05368731 chr17:41323189 NBR1 0.93 16.12 0.66 1.16e-43 Menopause (age at onset); LUSC cis rs12956009 0.518 rs1347343 chr18:44818996 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.77 0.35 5.8200000000000003e-11 Educational attainment (years of education); LUSC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs1185460 0.967 rs4454730 chr11:118937444 G/A cg23280166 chr11:118938394 VPS11 0.48 7.62 0.39 2.57e-13 Coronary artery disease; LUSC cis rs477692 1.000 rs565974 chr10:131423274 C/T cg11019008 chr10:131425282 MGMT 0.39 5.84 0.3 1.26e-8 Response to temozolomide; LUSC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg25036284 chr2:26402008 FAM59B -0.72 -9.87 -0.48 2.57e-20 Gut microbiome composition (summer); LUSC cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg23992470 chr4:843637 GAK 0.58 6.05 0.31 3.98e-9 Intelligence (multi-trait analysis); LUSC cis rs11577318 0.853 rs17645 chr1:26646730 A/G cg04990556 chr1:26633338 UBXN11 -0.48 -6.18 -0.32 1.87e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg00310523 chr12:86230176 RASSF9 0.49 9.32 0.45 1.62e-18 Major depressive disorder; LUSC cis rs3008870 0.959 rs2985808 chr1:67367741 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.11 0.64 1.12e-39 Lymphocyte percentage of white cells; LUSC trans rs10435719 0.902 rs7459983 chr8:11807221 T/C cg06636001 chr8:8085503 FLJ10661 0.55 8.16 0.41 6.7e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7296418 0.599 rs2277343 chr12:123794450 A/T cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.05 -0.4 1.42e-14 Platelet count; LUSC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg19812747 chr11:111475976 SIK2 0.53 7.68 0.39 1.77e-13 Primary sclerosing cholangitis; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.22 0.52 5.46e-25 Menopause (age at onset); LUSC cis rs714027 1.000 rs2412970 chr22:30486826 C/T cg11564601 chr22:30592435 NA 0.38 6.98 0.36 1.58e-11 Lymphocyte counts; LUSC trans rs61931739 0.857 rs419112 chr12:34130528 A/G cg26384229 chr12:38710491 ALG10B 0.57 9.04 0.44 1.32e-17 Morning vs. evening chronotype; LUSC cis rs977987 0.835 rs8057535 chr16:75347941 C/T cg04384234 chr16:75411784 CFDP1 -0.41 -6.71 -0.34 8.56e-11 Dupuytren's disease; LUSC cis rs7208487 0.684 rs12449852 chr17:37632088 A/G cg07936489 chr17:37558343 FBXL20 -0.8 -9.43 -0.46 7e-19 Primary biliary cholangitis;Glomerular filtration rate in non diabetics (creatinine); LUSC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg01181863 chr3:195395398 SDHAP2 0.59 9.56 0.46 2.58e-19 Bronchopulmonary dysplasia; LUSC cis rs9354308 0.901 rs2814096 chr6:66566131 G/A cg07460842 chr6:66804631 NA 0.47 5.8 0.3 1.53e-8 Metabolite levels; LUSC cis rs2011503 1.000 rs1036215 chr19:19657198 C/T cg22782873 chr19:19639568 YJEFN3 -0.53 -6.29 -0.33 9.98e-10 Bipolar disorder; LUSC cis rs17270561 0.609 rs2275905 chr6:25768106 G/A cg16482183 chr6:26056742 HIST1H1C 0.58 7.95 0.4 2.87e-14 Iron status biomarkers; LUSC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs8044995 0.501 rs73613999 chr16:68390099 C/A cg05110241 chr16:68378359 PRMT7 -0.78 -8.78 -0.43 8.66e-17 Schizophrenia; LUSC cis rs9326248 0.539 rs660443 chr11:116760693 T/C cg11861562 chr11:117069780 TAGLN 0.34 6.59 0.34 1.76e-10 Blood protein levels; LUSC cis rs11577318 0.853 rs4526602 chr1:26648034 C/T cg04990556 chr1:26633338 UBXN11 -0.48 -6.15 -0.32 2.24e-9 Granulocyte percentage of myeloid white cells; LUSC cis rs6582630 0.519 rs11495699 chr12:38286219 G/T cg26384229 chr12:38710491 ALG10B 0.93 15.94 0.66 5.93e-43 Drug-induced liver injury (flucloxacillin); LUSC cis rs62400317 0.859 rs11966878 chr6:45328265 C/T cg20913747 chr6:44695427 NA 0.48 7.69 0.39 1.69e-13 Total body bone mineral density; LUSC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg18306943 chr3:40428807 ENTPD3 0.38 5.86 0.31 1.13e-8 Renal cell carcinoma; LUSC cis rs6580649 0.941 rs7959755 chr12:48446318 T/A cg24011408 chr12:48396354 COL2A1 -0.46 -6.13 -0.32 2.43e-9 Lung cancer; LUSC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg04155289 chr7:94953770 PON1 -0.34 -5.76 -0.3 1.9e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs11098499 0.731 rs10015579 chr4:120271802 T/C cg09307838 chr4:120376055 NA 0.63 9.59 0.46 2.07e-19 Corneal astigmatism; LUSC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg13206674 chr6:150067644 NUP43 0.57 8.82 0.43 6.37e-17 Lung cancer; LUSC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg17179660 chr6:151773299 C6orf211;RMND1 -0.57 -8.64 -0.43 2.28e-16 Menarche (age at onset); LUSC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg24250549 chr1:154909240 PMVK -0.45 -6.85 -0.35 3.49e-11 Prostate cancer; LUSC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4862307 0.836 rs11132220 chr4:184997247 A/T cg06737308 chr4:185021514 ENPP6 -0.5 -7.73 -0.39 1.31e-13 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg02772935 chr3:125709198 NA -0.48 -5.78 -0.3 1.7e-8 Blood pressure (smoking interaction); LUSC trans rs7824557 0.592 rs2572371 chr8:11223793 G/T cg15556689 chr8:8085844 FLJ10661 0.47 7.26 0.37 2.66e-12 Retinal vascular caliber; LUSC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11890956 chr21:40555474 PSMG1 1.03 20.21 0.74 6.86e-60 Cognitive function; LUSC cis rs5758659 0.652 rs5758553 chr22:42431429 G/A cg04733989 chr22:42467013 NAGA 0.42 7.08 0.36 8.62e-12 Cognitive function; LUSC cis rs1371867 0.846 rs2047249 chr8:101234126 A/G cg00191853 chr8:101177733 SPAG1 0.39 6.16 0.32 2.14e-9 Atrioventricular conduction; LUSC cis rs425277 1.000 rs262670 chr1:2082458 C/T cg03732007 chr1:2071316 PRKCZ 0.48 7.85 0.39 5.6e-14 Height; LUSC cis rs7909074 0.798 rs10900126 chr10:45386322 G/T cg04218760 chr10:45406644 TMEM72 -0.3 -7.09 -0.36 7.8e-12 Mean corpuscular volume; LUSC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg18230493 chr5:56204884 C5orf35 -0.95 -13.95 -0.61 3.51e-35 Initial pursuit acceleration; LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg08677398 chr8:58056175 NA 0.58 6.91 0.35 2.52e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.56 -0.34 2.06e-10 Schizophrenia; LUSC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg21724239 chr8:58056113 NA 0.78 9.03 0.44 1.43e-17 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00128877 chr1:47070178 MKNK1 0.46 7.13 0.36 6.15e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs5769765 0.837 rs4824110 chr22:50271631 T/A cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg04025307 chr7:1156635 C7orf50 0.57 9.05 0.44 1.19e-17 Longevity;Endometriosis; LUSC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg24733560 chr20:60626293 TAF4 0.37 6.09 0.32 3.12e-9 Body mass index; LUSC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6951245 0.882 rs56048221 chr7:1092533 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.51 6.15 0.32 2.17e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs478304 0.651 rs4014195 chr11:65506822 C/G cg27068330 chr11:65405492 SIPA1 0.74 10.78 0.51 1.89e-23 Acne (severe); LUSC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg02038168 chr22:39784481 NA -0.5 -8.18 -0.41 5.88e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg10130564 chr11:117069849 TAGLN 0.37 6.26 0.32 1.16e-9 Blood protein levels; LUSC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg15664640 chr17:80829946 TBCD 0.47 8.44 0.42 9.53e-16 Breast cancer; LUSC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg13319975 chr6:146136371 FBXO30 0.69 10.63 0.5 6.28e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC cis rs12545109 1.000 rs2217957 chr8:57313360 T/C cg09654669 chr8:57350985 NA -0.61 -8.51 -0.42 6.03e-16 Obesity-related traits; LUSC cis rs524023 1.000 rs9734313 chr11:64358311 C/T cg19131476 chr11:64387923 NRXN2 -0.37 -10.05 -0.48 5.96e-21 Urate levels in obese individuals; LUSC cis rs997295 0.713 rs9302245 chr15:68021137 C/T cg08079166 chr15:68083412 MAP2K5 -0.34 -6.67 -0.34 1.07e-10 Motion sickness; LUSC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg23649088 chr2:200775458 C2orf69 0.54 7.35 0.37 1.58e-12 Schizophrenia; LUSC cis rs2932538 0.922 rs36029940 chr1:113106444 T/G cg22162597 chr1:113214053 CAPZA1 0.7 9.96 0.48 1.21e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg13047869 chr3:10149882 C3orf24 -0.41 -6.36 -0.33 6.45e-10 Alzheimer's disease; LUSC trans rs561341 0.825 rs2008368 chr17:30347397 T/C cg27661571 chr11:113659931 NA -0.69 -7.82 -0.39 6.91e-14 Hip circumference adjusted for BMI; LUSC cis rs977987 0.872 rs1542864 chr16:75471378 G/A cg04384234 chr16:75411784 CFDP1 -0.45 -7.44 -0.38 8.61e-13 Dupuytren's disease; LUSC cis rs1003719 0.680 rs2835621 chr21:38510616 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.81e-22 Eye color traits; LUSC cis rs11190604 0.731 rs10883480 chr10:102163821 G/T cg07080220 chr10:102295463 HIF1AN -0.56 -7.61 -0.38 2.74e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs8058578 1.000 rs6565201 chr16:30747191 C/T cg02466173 chr16:30829666 NA -0.6 -11.22 -0.52 5.43e-25 Multiple myeloma; LUSC cis rs9329221 0.527 rs7833781 chr8:10333477 A/G cg21775007 chr8:11205619 TDH 0.42 5.72 0.3 2.38e-8 Neuroticism; LUSC cis rs941408 1.000 rs1640272 chr19:2800192 A/T cg06609049 chr19:2785107 THOP1 0.65 10.31 0.49 8.33e-22 Total cholesterol levels; LUSC cis rs791888 0.688 rs1980649 chr10:89422375 T/C cg13926569 chr10:89418898 PAPSS2 0.36 7.1 0.36 7.63e-12 Magnesium levels; LUSC cis rs12760731 0.565 rs71628268 chr1:178151908 T/C cg00404053 chr1:178313656 RASAL2 0.75 7.4 0.38 1.12e-12 Obesity-related traits; LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 9.1 0.45 8.47e-18 Urate levels; LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs6500602 0.739 rs4786502 chr16:4537104 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.5 6.66 0.34 1.1e-10 Schizophrenia; LUSC cis rs9633740 0.773 rs1870148 chr10:82271341 G/A cg01528321 chr10:82214614 TSPAN14 1.07 11.78 0.54 4.98e-27 Post bronchodilator FEV1; LUSC cis rs7100689 0.646 rs1340384 chr10:82088702 T/A cg01528321 chr10:82214614 TSPAN14 0.82 12.33 0.56 4.69e-29 Post bronchodilator FEV1; LUSC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.3 5.81 0.3 1.46e-8 Intelligence (multi-trait analysis); LUSC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg12310025 chr6:25882481 NA -0.61 -10.22 -0.49 1.57e-21 Intelligence (multi-trait analysis); LUSC cis rs11048434 0.761 rs12824380 chr12:9132017 A/G cg13575925 chr12:9217583 LOC144571 0.34 6.27 0.32 1.14e-9 Sjögren's syndrome; LUSC trans rs7838490 0.780 rs28783381 chr8:89705802 T/G cg24558378 chr1:183589673 NA 0.34 6.26 0.32 1.22e-9 Body mass index and cholesterol (psychopharmacological treatment); LUSC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs7829975 0.560 rs4841013 chr8:8552013 A/G cg15556689 chr8:8085844 FLJ10661 -0.51 -7.31 -0.37 1.98e-12 Mood instability; LUSC trans rs9388451 0.869 rs7764016 chr6:126070789 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.62 -9.89 -0.48 2.09e-20 Brugada syndrome; LUSC cis rs61931739 0.500 rs7308338 chr12:34553181 A/G cg06521331 chr12:34319734 NA -0.4 -6.47 -0.33 3.46e-10 Morning vs. evening chronotype; LUSC cis rs950027 0.620 rs1153857 chr15:45659095 G/T cg26924012 chr15:45694286 SPATA5L1 0.79 12.5 0.56 1.13e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.67e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg08773314 chr2:239334832 ASB1 -0.43 -9.38 -0.46 1.06e-18 Multiple system atrophy; LUSC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg24881330 chr22:46731750 TRMU 0.83 7.5 0.38 5.79e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg09640425 chr7:158790006 NA 0.53 8.45 0.42 9.06e-16 Facial morphology (factor 20); LUSC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg14784868 chr12:69753453 YEATS4 0.64 9.48 0.46 4.97e-19 Blood protein levels; LUSC cis rs12410462 0.502 rs115241368 chr1:227795465 A/G cg23173402 chr1:227635558 NA 0.65 6.54 0.34 2.35e-10 Major depressive disorder; LUSC trans rs853679 0.567 rs2232427 chr6:28359709 T/G cg01620082 chr3:125678407 NA -0.44 -6.38 -0.33 6.04e-10 Depression; LUSC cis rs7586879 0.789 rs7560156 chr2:25124794 T/C cg01884057 chr2:25150051 NA 0.42 8.8 0.43 7.49e-17 Body mass index; LUSC cis rs28493229 0.748 rs10426415 chr19:41183590 A/G cg21869046 chr19:41225005 ITPKC 0.54 7.03 0.36 1.21e-11 Kawasaki disease; LUSC cis rs3126085 0.935 rs3126048 chr1:152260165 T/C cg26876637 chr1:152193138 HRNR -0.46 -6.37 -0.33 6.23e-10 Atopic dermatitis; LUSC cis rs7772486 0.712 rs1292335 chr6:145967877 G/T cg05347473 chr6:146136440 FBXO30 0.4 6.55 0.34 2.17e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs34779708 0.733 rs12249814 chr10:35542757 T/C cg03585969 chr10:35415529 CREM 0.55 7.69 0.39 1.71e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs2502731 0.539 rs3003615 chr9:130997892 C/T cg09976142 chr9:130955436 CIZ1 0.45 7.7 0.39 1.59e-13 Attention deficit hyperactivity disorder; LUSC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.23 0.41 4.12e-15 Melanoma; LUSC cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg15997130 chr1:24165203 NA 0.52 8.61 0.43 2.88e-16 Immature fraction of reticulocytes; LUSC cis rs56399783 0.901 rs73049305 chr7:2778755 C/T cg19731401 chr7:2775893 GNA12 0.72 8.67 0.43 1.95e-16 Childhood ear infection; LUSC cis rs7843479 0.601 rs10453141 chr8:21847235 T/C cg17168535 chr8:21777572 XPO7 0.82 14.97 0.63 3.82e-39 Mean corpuscular volume; LUSC cis rs6060717 0.536 rs17431878 chr20:34502107 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.69 -0.3 2.76e-8 Hip circumference adjusted for BMI; LUSC cis rs6463523 0.933 rs79984239 chr7:766220 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 1.0 21.64 0.76 1.6e-65 Subjective well-being; LUSC cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.42 0.38 9.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4631830 0.720 rs2012677 chr10:51504797 T/A cg16070123 chr10:51489643 NA -0.56 -9.31 -0.45 1.72e-18 Prostate-specific antigen levels; LUSC cis rs804280 0.560 rs10503426 chr8:11589383 A/C cg21775007 chr8:11205619 TDH 0.42 5.87 0.31 1.03e-8 Myopia (pathological); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08036850 chr12:121124877 MLEC 0.44 6.42 0.33 4.73e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg00409905 chr10:38381863 ZNF37A -0.36 -6.17 -0.32 2.03e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6669072 0.546 rs1025962 chr1:91264088 A/G cg08895590 chr1:91227319 NA -0.27 -5.8 -0.3 1.54e-8 Cognitive function; LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs61931739 0.679 rs10844831 chr12:34311245 G/T cg06521331 chr12:34319734 NA -0.4 -6.93 -0.35 2.23e-11 Morning vs. evening chronotype; LUSC cis rs4654899 0.865 rs12410467 chr1:21356055 G/A cg01072550 chr1:21505969 NA -0.54 -7.91 -0.4 3.75e-14 Superior frontal gyrus grey matter volume; LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg18404041 chr3:52824283 ITIH1 -0.57 -11.01 -0.52 2.85e-24 Bipolar disorder; LUSC cis rs806215 0.723 rs1090682 chr7:127245159 T/C cg25922125 chr7:127225783 GCC1 0.57 7.17 0.37 4.78e-12 Type 2 diabetes; LUSC cis rs7707921 1.000 rs17245188 chr5:81469082 A/C cg15871215 chr5:81402204 ATG10 0.43 6.47 0.33 3.57e-10 Breast cancer; LUSC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg15839431 chr19:19639596 YJEFN3 -0.51 -6.06 -0.31 3.66e-9 Tonsillectomy; LUSC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg07636037 chr3:49044803 WDR6 1.05 19.36 0.73 1.62e-56 Parkinson's disease; LUSC cis rs6733011 0.578 rs12468024 chr2:99495980 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.09 -0.32 3.18e-9 Bipolar disorder; LUSC trans rs7824557 0.583 rs4448232 chr8:11231354 G/T cg08975724 chr8:8085496 FLJ10661 0.48 7.06 0.36 9.6e-12 Retinal vascular caliber; LUSC cis rs6693567 0.545 rs9436009 chr1:150459426 T/A cg15654264 chr1:150340011 RPRD2 0.43 6.9 0.35 2.56e-11 Migraine; LUSC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg18252515 chr7:66147081 NA 1.14 12.86 0.58 5.13e-31 Diabetic kidney disease; LUSC cis rs7824557 0.767 rs7837036 chr8:11175489 A/G cg21293242 chr8:11204541 TDH 0.34 6.57 0.34 1.89e-10 Retinal vascular caliber; LUSC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg03806693 chr22:41940476 POLR3H -0.99 -14.25 -0.61 2.49e-36 Vitiligo; LUSC cis rs6964587 1.000 rs11982047 chr7:91705274 G/A cg17063962 chr7:91808500 NA 0.57 8.69 0.43 1.62e-16 Breast cancer; LUSC cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26030610 chr1:113933950 MAGI3 0.41 6.43 0.33 4.41e-10 Risky sexual behaviors in alcohol dependence; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg02974815 chr3:52091604 DUSP7 0.39 6.02 0.31 4.7e-9 Metabolite levels (Pyroglutamine); LUSC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg04944784 chr2:26401820 FAM59B -0.68 -9.42 -0.46 7.58e-19 Gut microbiome composition (summer); LUSC cis rs3806843 1.000 rs1548700 chr5:140164889 A/T cg19875535 chr5:140030758 IK 0.47 7.66 0.39 2.01e-13 Depressive symptoms (multi-trait analysis); LUSC trans rs13233308 0.836 rs6966166 chr7:87455155 C/T cg22633988 chr4:77610603 SHROOM3 -0.43 -6.32 -0.33 8.47e-10 Schizophrenia; LUSC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg04850211 chr1:228464232 OBSCN 0.32 5.68 0.3 2.92e-8 Diastolic blood pressure; LUSC cis rs929354 0.742 rs1182396 chr7:157031831 A/C cg05182265 chr7:156933206 UBE3C 0.58 9.44 0.46 6.38e-19 Body mass index; LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg01802117 chr1:53393560 SCP2 -0.37 -6.06 -0.31 3.75e-9 Monocyte count; LUSC cis rs2230307 0.536 rs506044 chr1:100611931 A/G cg24955406 chr1:100503596 HIAT1 -0.64 -6.87 -0.35 3.07e-11 Carotid intima media thickness; LUSC trans rs7613875 0.620 rs7624030 chr3:50071279 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -8.02 -0.4 1.78e-14 Body mass index; LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.1 -0.58 6.15e-32 Platelet count; LUSC cis rs710216 1.000 rs710216 chr1:43428757 A/G cg22176566 chr1:43424700 SLC2A1 0.46 5.83 0.3 1.33e-8 Red cell distribution width; LUSC cis rs9479482 0.967 rs1543547 chr6:150346532 T/C cg25797454 chr6:150327115 RAET1K 0.33 7.43 0.38 8.97e-13 Alopecia areata; LUSC cis rs721399 0.553 rs10109286 chr8:18243603 A/G cg18736775 chr8:18248649 NAT2 -0.62 -7.84 -0.39 6.07e-14 Blood metabolite levels; LUSC cis rs2742417 1.000 rs2742420 chr3:45732237 A/G cg09608765 chr3:45636137 LIMD1 -0.37 -7.21 -0.37 3.68e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7903847 0.642 rs2297667 chr10:99145492 A/T cg20016023 chr10:99160130 RRP12 -0.32 -7.7 -0.39 1.54e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs1152591 0.505 rs1152601 chr14:64667337 T/C cg21174375 chr14:64681225 SYNE2 0.32 5.82 0.3 1.39e-8 Atrial fibrillation; LUSC cis rs4622329 0.636 rs7976056 chr12:102313506 A/G cg23541617 chr12:102225335 GNPTAB 0.27 5.9 0.31 8.91e-9 Systemic lupus erythematosus; LUSC cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.4e-22 Alzheimer's disease (late onset); LUSC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg23277830 chr1:3704460 LRRC47 0.32 5.99 0.31 5.44e-9 Red cell distribution width; LUSC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg04369109 chr6:150039330 LATS1 -0.55 -8.1 -0.41 1.07e-14 Lung cancer; LUSC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs10751667 0.961 rs7482484 chr11:927020 C/T ch.11.42038R chr11:967971 AP2A2 0.53 7.83 0.39 6.49e-14 Alzheimer's disease (late onset); LUSC cis rs4499344 0.589 rs259218 chr19:33138125 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.88 13.06 0.58 9.07e-32 Mean platelet volume; LUSC cis rs7104764 0.507 rs7121085 chr11:258523 A/G cg00562011 chr11:252351 PSMD13 -0.51 -6.62 -0.34 1.42e-10 Menarche (age at onset); LUSC cis rs4148883 0.504 rs28720150 chr4:100132790 T/G cg12011299 chr4:100065546 ADH4 -0.42 -6.82 -0.35 4.17e-11 Alcohol dependence; LUSC cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg05855489 chr10:104503620 C10orf26 0.58 7.7 0.39 1.51e-13 Arsenic metabolism; LUSC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg00343986 chr7:65444356 GUSB -0.47 -7.01 -0.36 1.3e-11 Calcium levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07552157 chr3:142720316 SR140 -0.51 -6.88 -0.35 3.01e-11 Bipolar disorder and schizophrenia; LUSC cis rs9549260 0.755 rs2721044 chr13:41162225 C/T cg21288729 chr13:41239152 FOXO1 0.61 9.48 0.46 4.84e-19 Red blood cell count; LUSC cis rs11997175 0.692 rs6995075 chr8:33673816 G/A ch.8.33884649F chr8:33765107 NA 0.37 5.71 0.3 2.52e-8 Body mass index; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16504335 chr14:81902346 NA 0.76 6.25 0.32 1.24e-9 Cognitive performance; LUSC trans rs1994135 0.647 rs1351681 chr12:33698724 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.82 0.47 3.57e-20 Resting heart rate; LUSC cis rs4148883 0.628 rs34195655 chr4:100073795 C/T cg12011299 chr4:100065546 ADH4 0.48 7.88 0.4 4.78e-14 Alcohol dependence; LUSC cis rs9611565 0.592 rs12484467 chr22:41957610 T/C cg03806693 chr22:41940476 POLR3H -1.01 -13.75 -0.6 2.04e-34 Vitiligo; LUSC cis rs7084921 0.608 rs12773948 chr10:101865115 T/A cg11888571 chr10:102027403 CWF19L1 -0.45 -6.29 -0.33 1.02e-9 Bone mineral density; LUSC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg05347473 chr6:146136440 FBXO30 -0.67 -11.39 -0.53 1.34e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs3740713 1.000 rs16935432 chr11:18470487 G/A cg15463284 chr11:18477534 LDHAL6A -0.5 -5.73 -0.3 2.21e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg09365446 chr1:150670422 GOLPH3L 0.5 7.73 0.39 1.3e-13 Tonsillectomy; LUSC cis rs12545109 0.671 rs35500854 chr8:57424303 G/A cg09654669 chr8:57350985 NA -0.51 -6.62 -0.34 1.43e-10 Obesity-related traits; LUSC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg04267008 chr7:1944627 MAD1L1 -0.49 -7.33 -0.37 1.76e-12 Bipolar disorder and schizophrenia; LUSC cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg15485101 chr11:133734466 NA 0.42 7.58 0.38 3.54e-13 Childhood ear infection; LUSC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs12310956 0.527 rs1608910 chr12:33895414 T/C cg06521331 chr12:34319734 NA -0.35 -5.7 -0.3 2.61e-8 Morning vs. evening chronotype; LUSC cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.66 -0.39 1.97e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs59698941 0.943 rs67843388 chr5:132288007 C/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs929354 0.772 rs3802120 chr7:156977794 C/T cg17757837 chr7:157058334 UBE3C 0.82 13.05 0.58 9.46e-32 Body mass index; LUSC trans rs7726558 0.543 rs76058893 chr5:118844238 C/G cg14402224 chr7:50570049 DDC -0.47 -6.14 -0.32 2.31e-9 QT interval (sulfonylurea treatment interaction); LUSC cis rs12912251 1.000 rs12912251 chr15:38986368 G/T cg01338139 chr15:38987640 C15orf53 -0.49 -6.72 -0.35 7.68e-11 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs4919694 1.000 rs76892505 chr10:104719290 G/A cg04362960 chr10:104952993 NT5C2 1.18 13.25 0.59 1.78e-32 Arsenic metabolism; LUSC cis rs6920965 0.507 rs4285341 chr6:126205589 T/G cg10911889 chr6:126070802 HEY2 0.39 5.75 0.3 2.03e-8 High light scatter reticulocyte count; LUSC cis rs8017423 0.967 rs7151776 chr14:90724803 A/G cg14092571 chr14:90743983 NA -0.38 -6.44 -0.33 4.25e-10 Mortality in heart failure; LUSC cis rs12984174 1.000 rs403439 chr19:18142075 A/G cg21649277 chr19:18117794 ARRDC2 -0.62 -6.7 -0.34 8.79e-11 Pulmonary function in asthmatics; LUSC cis rs1003719 0.788 rs2835592 chr21:38464387 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs1018836 0.631 rs9987133 chr8:91470730 T/C cg16814680 chr8:91681699 NA -0.56 -8.27 -0.41 3.28e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs208520 1.000 rs12216109 chr6:66987488 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.94 0.55 1.29e-27 Exhaled nitric oxide output; LUSC cis rs317689 0.788 rs317679 chr12:69693172 A/C cg20891283 chr12:69753455 YEATS4 0.46 6.31 0.33 9.07e-10 Response to diuretic therapy; LUSC cis rs1983891 1.000 rs2104506 chr6:41533579 C/A cg15051332 chr6:41514432 FOXP4 0.4 5.85 0.3 1.16e-8 Prostate cancer; LUSC cis rs2486288 0.656 rs11632419 chr15:45557456 C/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.0 -0.4 2.14e-14 Glomerular filtration rate; LUSC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg20933634 chr6:27740509 NA 0.42 6.02 0.31 4.64e-9 Parkinson's disease; LUSC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg11366901 chr6:160182831 ACAT2 0.95 12.93 0.58 2.72e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg23262073 chr20:60523788 NA -0.38 -5.83 -0.3 1.34e-8 Body mass index; LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04871131 chr7:94954202 PON1 -0.47 -8.85 -0.44 5.31e-17 Paraoxonase activity; LUSC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.74 -0.3 2.1e-8 Alzheimer's disease (late onset); LUSC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg01097406 chr16:89675127 NA -0.36 -6.88 -0.35 2.99e-11 Hemoglobin concentration; LUSC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs2717559 0.561 rs7841267 chr8:143881683 A/C cg17252645 chr8:143867129 LY6D -0.56 -10.58 -0.5 9.6e-23 Urinary tract infection frequency; LUSC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg08219700 chr8:58056026 NA 0.65 8.72 0.43 1.36e-16 Developmental language disorder (linguistic errors); LUSC cis rs7177699 0.557 rs55870734 chr15:79117917 A/T cg15571903 chr15:79123663 NA -0.33 -6.13 -0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg26314531 chr2:26401878 FAM59B 0.72 10.16 0.49 2.55e-21 Gut microbiome composition (summer); LUSC cis rs7647973 1.000 rs11710434 chr3:49346130 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.41 6.33 0.33 7.79e-10 Menarche (age at onset); LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg11645453 chr3:52864694 ITIH4 0.32 7.48 0.38 6.77e-13 Bipolar disorder; LUSC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg24250549 chr1:154909240 PMVK 0.57 9.03 0.44 1.37e-17 Prostate cancer; LUSC trans rs877282 0.891 rs11595385 chr10:800539 A/G cg13042288 chr15:90349979 ANPEP -0.5 -6.94 -0.36 2.01e-11 Uric acid levels; LUSC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.41 0.46 8.32e-19 Monocyte percentage of white cells; LUSC cis rs2839186 0.900 rs2839200 chr21:47709095 C/T cg12379764 chr21:47803548 PCNT -0.42 -5.88 -0.31 9.69e-9 Testicular germ cell tumor; LUSC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg04518342 chr5:131593106 PDLIM4 -0.43 -7.28 -0.37 2.38e-12 Breast cancer; LUSC cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg03146154 chr1:46216737 IPP 0.51 7.42 0.38 9.87e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7914558 0.621 rs12219346 chr10:104657300 T/C cg05855489 chr10:104503620 C10orf26 0.43 5.77 0.3 1.84e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg23649088 chr2:200775458 C2orf69 -0.58 -7.07 -0.36 8.87e-12 Schizophrenia; LUSC cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.44 6.18 0.32 1.84e-9 Rheumatoid arthritis; LUSC cis rs3784262 1.000 rs10851630 chr15:58242148 C/T cg12031962 chr15:58353849 ALDH1A2 -0.33 -6.06 -0.31 3.72e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7582720 1.000 rs4510208 chr2:203734866 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.76 8.31 0.41 2.46e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7605827 0.930 rs6705287 chr2:15529368 A/C cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.51 7.59e-24 Schizophrenia; LUSC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.39 7.63 0.39 2.4e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg16031515 chr1:205743344 RAB7L1 -0.3 -6.36 -0.33 6.52e-10 Menarche (age at onset); LUSC trans rs2898290 0.622 rs11250140 chr8:11346592 A/C cg08975724 chr8:8085496 FLJ10661 -0.43 -6.35 -0.33 7.06e-10 Systolic blood pressure; LUSC cis rs2832077 0.943 rs2832099 chr21:30173460 A/G cg24692254 chr21:30365293 RNF160 -0.54 -6.96 -0.36 1.79e-11 Cognitive test performance; LUSC cis rs1215050 0.782 rs6532693 chr4:98655815 T/C cg05340658 chr4:99064831 C4orf37 -0.46 -7.26 -0.37 2.68e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9840812 0.725 rs3821445 chr3:136002809 T/C cg15507776 chr3:136538369 TMEM22 -0.45 -5.87 -0.31 1.06e-8 Fibrinogen levels; LUSC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg18876405 chr7:65276391 NA -0.56 -8.81 -0.43 7.03e-17 Aortic root size; LUSC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg01283332 chr5:1856932 NA -0.34 -6.38 -0.33 6.02e-10 Cardiovascular disease risk factors; LUSC cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg00857998 chr1:205179979 DSTYK 0.58 8.82 0.43 6.39e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.14 0.36 5.96e-12 Hip circumference adjusted for BMI; LUSC cis rs4974559 0.947 rs10018627 chr4:1356358 G/A cg02980000 chr4:1222292 CTBP1 0.73 7.34 0.37 1.59e-12 Systolic blood pressure; LUSC cis rs6570726 0.905 rs377143 chr6:145834220 C/T cg23711669 chr6:146136114 FBXO30 0.72 12.58 0.57 5.87e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg16647868 chr5:131706066 SLC22A5 0.39 5.94 0.31 7.3e-9 Breast cancer; LUSC cis rs6430585 0.584 rs4954276 chr2:136402117 A/G cg07169764 chr2:136633963 MCM6 0.53 7.08 0.36 8.77e-12 Corneal structure; LUSC cis rs4664304 0.802 rs3749114 chr2:160832996 A/T cg03641300 chr2:160917029 PLA2R1 -0.39 -6.24 -0.32 1.34e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs8044995 0.563 rs1110572 chr16:68396119 A/G cg09835421 chr16:68378352 PRMT7 -0.76 -8.23 -0.41 4.35e-15 Schizophrenia; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg18301423 chr5:131593218 PDLIM4 0.38 6.2 0.32 1.66e-9 Blood metabolite levels; LUSC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg15691649 chr6:25882328 NA -0.39 -5.78 -0.3 1.75e-8 Intelligence (multi-trait analysis); LUSC cis rs8028313 0.731 rs13380201 chr15:67973665 A/G cg08079166 chr15:68083412 MAP2K5 0.36 6.23 0.32 1.39e-9 Obesity; LUSC cis rs8014204 0.816 rs4903262 chr14:75340818 A/G cg06637938 chr14:75390232 RPS6KL1 0.53 8.37 0.42 1.55e-15 Caffeine consumption; LUSC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs4811340 0.600 rs6068251 chr20:51180110 G/A cg15736553 chr3:11610338 VGLL4 -0.33 -5.95 -0.31 6.7e-9 Thyroid peroxidase antibody positivity; LUSC cis rs8062405 0.754 rs62034323 chr16:28536473 C/T cg16576597 chr16:28551801 NUPR1 0.29 5.75 0.3 2.01e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs1784581 0.802 rs2156747 chr6:162430000 C/G cg17173639 chr6:162384350 PARK2 -0.65 -11.23 -0.52 4.66e-25 Itch intensity from mosquito bite; LUSC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.46 0.53 7.26e-26 Menopause (age at onset); LUSC cis rs7577696 0.597 rs212751 chr2:32418808 T/A cg02381751 chr2:32503542 YIPF4 0.53 7.1 0.36 7.62e-12 Inflammatory biomarkers; LUSC cis rs12681287 0.547 rs60982560 chr8:87515046 C/T cg00550725 chr8:87521180 FAM82B 0.44 5.75 0.3 2.07e-8 Caudate activity during reward; LUSC cis rs1595825 0.945 rs1518369 chr2:198859183 C/T cg10547527 chr2:198650123 BOLL -0.49 -5.89 -0.31 9.29e-9 Ulcerative colitis; LUSC cis rs5758511 0.773 rs62241023 chr22:42385429 G/A cg12850546 chr22:42539477 CYP2D7P1 -0.56 -6.74 -0.35 7.04e-11 Birth weight; LUSC cis rs672059 1.000 rs551569 chr1:183158293 G/C ch.1.3577855R chr1:183094577 LAMC1 0.54 7.98 0.4 2.42e-14 Hypertriglyceridemia; LUSC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg12963246 chr6:28129442 ZNF389 0.41 5.69 0.3 2.75e-8 Parkinson's disease; LUSC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 7.78 0.39 9.16e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg06671706 chr8:8559999 CLDN23 0.5 6.69 0.34 9.65e-11 Obesity-related traits; LUSC cis rs911119 0.913 rs2405392 chr20:23569186 C/T cg16589663 chr20:23618590 CST3 0.63 7.33 0.37 1.74e-12 Chronic kidney disease; LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg17644776 chr2:200775616 C2orf69 -0.5 -8.85 -0.44 5.02e-17 Osteoporosis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20550224 chr17:47929286 NA 0.74 6.37 0.33 6.3e-10 Cognitive performance; LUSC trans rs11700980 0.551 rs77334403 chr21:30109398 A/G cg14791747 chr16:20752902 THUMPD1 0.55 5.98 0.31 5.75e-9 QRS complex (12-leadsum); LUSC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg15445000 chr17:37608096 MED1 0.4 6.86 0.35 3.35e-11 Glomerular filtration rate (creatinine); LUSC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg07150166 chr2:30669952 LCLAT1 0.64 7.23 0.37 3.21e-12 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.09 14.9 0.63 7.52e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs868036 1.000 rs8037262 chr15:68108572 C/T cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs57590327 0.503 rs1461611 chr3:81512061 C/A cg07356753 chr3:81810745 GBE1 0.46 6.1 0.32 3.01e-9 Extraversion; LUSC cis rs3820068 0.603 rs7516453 chr1:15972558 C/G cg24675056 chr1:15929824 NA 0.48 7.96 0.4 2.79e-14 Systolic blood pressure; LUSC cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg16928487 chr17:17741425 SREBF1 -0.51 -9.63 -0.47 1.55e-19 Total body bone mineral density; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03584783 chr1:173836803 GAS5;SNORD76;SNORD75;SNORD77;ZBTB37 -0.51 -6.48 -0.33 3.33e-10 Bipolar disorder and schizophrenia; LUSC cis rs4478858 0.684 rs1546375 chr1:31765968 C/T cg00250761 chr1:31883323 NA -0.35 -8.37 -0.42 1.61e-15 Alcohol dependence; LUSC cis rs11098499 0.863 rs12508173 chr4:120318526 T/C cg09307838 chr4:120376055 NA 0.79 11.38 0.53 1.46e-25 Corneal astigmatism; LUSC cis rs62400317 0.859 rs62436760 chr6:45112604 T/C cg18551225 chr6:44695536 NA -0.41 -6.84 -0.35 3.88e-11 Total body bone mineral density; LUSC cis rs977987 0.800 rs12935787 chr16:75332335 C/T cg04384234 chr16:75411784 CFDP1 -0.37 -5.94 -0.31 7.31e-9 Dupuytren's disease; LUSC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg03351412 chr1:154909251 PMVK 0.51 7.84 0.39 5.99e-14 Prostate cancer; LUSC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg21918786 chr6:109611834 NA -0.38 -6.45 -0.33 3.9e-10 Reticulocyte fraction of red cells; LUSC cis rs926938 0.527 rs360681 chr1:115496741 C/G cg12756093 chr1:115239321 AMPD1 0.46 6.92 0.35 2.35e-11 Autism; LUSC cis rs6556937 0.627 rs7705824 chr5:96005617 A/C cg07690455 chr5:95997198 CAST 0.49 6.78 0.35 5.52e-11 Blood protein levels; LUSC cis rs6121246 0.567 rs6060260 chr20:30192907 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC cis rs9467711 0.606 rs2073527 chr6:26374978 T/C cg09904177 chr6:26538194 HMGN4 -0.74 -6.95 -0.36 1.9e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7481584 0.624 rs516443 chr11:3047294 A/G cg25174290 chr11:3078921 CARS -0.41 -6.22 -0.32 1.49e-9 Calcium levels; LUSC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs7843479 0.524 rs1031884 chr8:21788984 C/T cg17168535 chr8:21777572 XPO7 0.85 15.85 0.66 1.34e-42 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4986172 0.690 rs11657325 chr17:43242694 C/T cg10701640 chr17:43249399 NA 0.46 10.02 0.48 7.96e-21 Height; LUSC cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs713587 0.776 rs1172294 chr2:25169200 A/G cg15423357 chr2:25149977 NA 0.37 7.35 0.37 1.49e-12 Body mass index in non-asthmatics; LUSC cis rs4466137 0.909 rs4466136 chr5:82985576 T/G cg15083037 chr5:83017644 HAPLN1 -0.6 -8.01 -0.4 1.94e-14 Prostate cancer; LUSC cis rs782590 0.902 rs782602 chr2:55849309 A/G cg03859395 chr2:55845619 SMEK2 0.81 14.81 0.63 1.66e-38 Metabolic syndrome; LUSC cis rs8141529 0.732 rs2269577 chr22:29196757 G/C cg15103426 chr22:29168792 CCDC117 0.6 8.37 0.42 1.65e-15 Lymphocyte counts; LUSC cis rs7833986 0.501 rs72653948 chr8:56955689 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.73 12.21 0.56 1.35e-28 Height; LUSC cis rs17828380 0.920 rs35902265 chr15:63600524 C/T cg05507819 chr15:63340323 TPM1 -0.75 -6.13 -0.32 2.5e-9 Social communication problems; LUSC cis rs10504229 0.516 rs4060631 chr8:57990757 G/A cg22535103 chr8:58192502 C8orf71 -0.49 -6.43 -0.33 4.5e-10 Developmental language disorder (linguistic errors); LUSC trans rs72674100 1.000 rs72880546 chr4:97973701 T/C cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10089 0.953 rs758179 chr5:127354424 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.82 11.32 0.53 2.27e-25 Ileal carcinoids; LUSC cis rs868036 0.881 rs12708496 chr15:68054098 T/C cg08079166 chr15:68083412 MAP2K5 -0.42 -8.68 -0.43 1.8e-16 Restless legs syndrome; LUSC cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg24642439 chr20:33292090 TP53INP2 0.47 7.1 0.36 7.61e-12 Glomerular filtration rate (creatinine); LUSC cis rs10463316 0.894 rs11167542 chr5:150760282 A/G cg03212797 chr5:150827313 SLC36A1 0.49 7.39 0.38 1.16e-12 Metabolite levels (Pyroglutamine); LUSC cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg05347473 chr6:146136440 FBXO30 0.5 8.56 0.42 4.31e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs1018697 1.000 rs4919678 chr10:104554363 C/G cg04362960 chr10:104952993 NT5C2 0.47 6.46 0.33 3.65e-10 Colorectal adenoma (advanced); LUSC cis rs1385374 0.858 rs12305142 chr12:129277490 C/T cg09035930 chr12:129282057 SLC15A4 -0.61 -6.52 -0.34 2.53e-10 Systemic lupus erythematosus; LUSC cis rs3892630 0.824 rs2287882 chr19:33332952 C/T cg22980127 chr19:33182716 NUDT19 0.89 11.63 0.54 1.81e-26 Red blood cell traits; LUSC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.74 0.35 6.99e-11 Intelligence (multi-trait analysis); LUSC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg19717773 chr7:2847554 GNA12 -0.38 -6.04 -0.31 4.12e-9 Height; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg09436375 chr6:42928200 GNMT -0.3 -6.87 -0.35 3.09e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2749592 0.531 rs1208559 chr10:38221370 T/C cg25427524 chr10:38739819 LOC399744 0.73 13.19 0.59 2.77e-32 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7799006 0.606 rs12535174 chr7:2310974 C/T cg02951883 chr7:2050386 MAD1L1 -0.35 -5.76 -0.3 1.95e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7189233 0.531 rs1072911 chr16:53499725 T/C cg09728985 chr16:53543985 NA -0.33 -6.21 -0.32 1.58e-9 Intelligence (multi-trait analysis); LUSC trans rs877282 0.853 rs10904545 chr10:757100 G/A cg13042288 chr15:90349979 ANPEP -0.47 -6.49 -0.33 3.1e-10 Uric acid levels; LUSC cis rs116988415 0.786 rs118028978 chr14:65302112 C/T cg00114569 chr14:65239327 SPTB 0.54 5.76 0.3 1.9e-8 Daytime sleep phenotypes; LUSC cis rs6489785 0.710 rs3213566 chr12:121222578 T/C cg02403541 chr12:121454288 C12orf43 0.39 5.75 0.3 2.03e-8 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg04944784 chr2:26401820 FAM59B 0.64 8.55 0.42 4.47e-16 Gut microbiome composition (summer); LUSC cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg07606381 chr6:8435919 SLC35B3 0.72 12.13 0.55 2.61e-28 Motion sickness; LUSC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 9.58 0.46 2.35e-19 Personality dimensions; LUSC cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg04990556 chr1:26633338 UBXN11 -0.44 -5.88 -0.31 9.82e-9 Granulocyte percentage of myeloid white cells; LUSC trans rs11098499 0.908 rs71614449 chr4:120387055 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.2 0.32 1.7e-9 Corneal astigmatism; LUSC trans rs11098499 0.789 rs12498994 chr4:120250818 A/C cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.81 -0.43 7.12e-17 Bipolar disorder; LUSC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg21573476 chr21:45109991 RRP1B -0.44 -7.04 -0.36 1.1e-11 Mean corpuscular volume; LUSC cis rs4242434 0.699 rs878053 chr8:22483849 T/C cg03733263 chr8:22462867 KIAA1967 0.77 12.59 0.57 5.21e-30 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs11676348 0.712 rs11687434 chr2:218945143 A/G cg00012203 chr2:219082015 ARPC2 -0.5 -7.77 -0.39 9.46e-14 Ulcerative colitis; LUSC cis rs713477 0.935 rs4901567 chr14:55912698 C/T cg13175173 chr14:55914753 NA -0.3 -6.37 -0.33 6.32e-10 Pediatric bone mineral content (femoral neck); LUSC cis rs6574644 0.916 rs6574640 chr14:81771810 T/G cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg05347473 chr6:146136440 FBXO30 -0.59 -9.32 -0.45 1.58e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg24881330 chr22:46731750 TRMU 0.85 7.29 0.37 2.25e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs1322512 0.917 rs1918331 chr6:152944123 T/G cg27316956 chr6:152958899 SYNE1 -0.36 -5.89 -0.31 9.32e-9 Tonometry; LUSC cis rs11048434 0.736 rs12821842 chr12:9108984 G/A cg13575925 chr12:9217583 LOC144571 0.35 6.48 0.33 3.2e-10 Sjögren's syndrome; LUSC cis rs911119 0.955 rs8115423 chr20:23605253 T/C cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.37e-11 Chronic kidney disease; LUSC cis rs9611565 0.918 rs6002351 chr22:41757223 C/T cg03806693 chr22:41940476 POLR3H -0.78 -11.21 -0.52 5.55e-25 Vitiligo; LUSC cis rs6087990 1.000 rs1007123 chr20:31345840 G/A cg13636640 chr20:31349939 DNMT3B 1.04 22.97 0.78 1.05e-70 Ulcerative colitis; LUSC cis rs11864453 0.826 rs6499559 chr16:72132064 G/C cg01557791 chr16:72042693 DHODH -0.51 -7.33 -0.37 1.74e-12 Fibrinogen levels; LUSC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -5.65 -0.3 3.53e-8 Calcium levels; LUSC trans rs61931739 0.517 rs7486246 chr12:34526419 T/G cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg01879757 chr17:41196368 BRCA1 -0.46 -6.97 -0.36 1.72e-11 Menopause (age at onset); LUSC cis rs6426558 0.537 rs7512409 chr1:227484038 A/G cg10327440 chr1:227177885 CDC42BPA -0.55 -7.68 -0.39 1.73e-13 Neutrophil percentage of white cells; LUSC cis rs7772486 0.875 rs932522 chr6:146374026 A/G cg23711669 chr6:146136114 FBXO30 -0.85 -14.55 -0.62 1.72e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg06022373 chr22:39101656 GTPBP1 -0.68 -10.47 -0.5 2.22e-22 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20932348 chr4:26862197 STIM2 0.46 6.45 0.33 3.85e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12618769 0.597 rs3769725 chr2:99105967 A/G cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC cis rs7511006 0.859 rs7292228 chr22:50649560 C/G cg08875078 chr22:50639485 SELO 0.44 6.09 0.32 3.13e-9 Obesity-related traits; LUSC cis rs7568458 0.660 rs55692129 chr2:85792404 A/T cg17127132 chr2:85788382 GGCX 0.42 6.02 0.31 4.48e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11105298 0.891 rs10858851 chr12:89830870 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.02 -0.36 1.24e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs870825 0.616 rs10022834 chr4:185649431 A/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs765787 0.530 rs28414644 chr15:45536721 G/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.71 -0.43 1.44e-16 Uric acid levels; LUSC cis rs1864400 0.605 rs12360493 chr10:43718613 A/G cg15436174 chr10:43711423 RASGEF1A 0.39 6.5 0.34 2.9e-10 Hirschsprung disease; LUSC cis rs614226 1.000 rs7174 chr12:121017171 A/G cg21053147 chr12:120880522 NA -0.48 -5.83 -0.3 1.33e-8 Type 1 diabetes nephropathy; LUSC cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg22709100 chr7:91322751 NA 0.4 5.85 0.3 1.16e-8 Breast cancer; LUSC cis rs8067354 0.645 rs2665400 chr17:57880201 G/A cg02344993 chr17:57696989 CLTC 0.48 7.11 0.36 7.3e-12 Hemoglobin concentration; LUSC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg05340658 chr4:99064831 C4orf37 0.6 10.04 0.48 6.58e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg08999081 chr20:33150536 PIGU 0.44 8.24 0.41 3.86e-15 Coronary artery disease; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg05451912 chr6:26285795 HIST1H4H 0.48 6.0 0.31 5.19e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6456156 0.586 rs2001115 chr6:167486218 A/C cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg13010199 chr12:38710504 ALG10B 0.7 10.93 0.51 5.81e-24 Bladder cancer; LUSC cis rs826838 0.559 rs1843891 chr12:38617018 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.84 0.44 5.5e-17 Heart rate; LUSC cis rs6964587 0.869 rs6946764 chr7:91539003 A/G cg22709100 chr7:91322751 NA -0.4 -5.84 -0.3 1.21e-8 Breast cancer; LUSC cis rs4820539 0.966 rs2267005 chr22:23461723 A/G cg14186256 chr22:23484241 RTDR1 0.96 17.77 0.7 3.33e-50 Bone mineral density; LUSC cis rs4820539 0.934 rs3788351 chr22:23469181 T/C cg14186256 chr22:23484241 RTDR1 0.93 16.57 0.67 1.93e-45 Bone mineral density; LUSC cis rs9535307 0.929 rs1407441 chr13:50290990 T/C cg04663916 chr13:50265991 EBPL 0.49 5.71 0.3 2.44e-8 Obesity-related traits; LUSC trans rs961253 0.522 rs2148813 chr20:6352470 T/C cg21095983 chr6:86352623 SYNCRIP 0.46 6.97 0.36 1.67e-11 Colorectal cancer; LUSC cis rs73206853 0.841 rs78843188 chr12:110827923 G/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs9549367 0.713 rs4907599 chr13:113861441 C/T cg18105134 chr13:113819100 PROZ 0.66 10.02 0.48 7.77e-21 Platelet distribution width; LUSC cis rs8048589 0.615 rs12599107 chr16:12238602 G/A cg02910054 chr16:12241554 SNX29 0.51 6.35 0.33 7.18e-10 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg08027265 chr7:2291960 NA -0.39 -6.43 -0.33 4.52e-10 Bipolar disorder and schizophrenia; LUSC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg15782153 chr7:917662 C7orf20 0.45 6.79 0.35 5.25e-11 Perceived unattractiveness to mosquitoes; LUSC cis rs1185460 0.967 rs11217133 chr11:118928249 G/A cg01677386 chr11:118938358 VPS11 -0.51 -6.94 -0.35 2.06e-11 Coronary artery disease; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg16405210 chr4:1374714 KIAA1530 0.71 10.97 0.51 4.08e-24 Obesity-related traits; LUSC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.45 -7.12 -0.36 6.52e-12 Alzheimer's disease (late onset); LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg19318889 chr4:1322082 MAEA 0.79 14.07 0.61 1.21e-35 Longevity; LUSC cis rs3741151 0.773 rs17244616 chr11:73293112 C/T cg17517138 chr11:73019481 ARHGEF17 0.93 8.04 0.4 1.55e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs62055045 0.528 rs62056191 chr16:71533831 C/T cg23742233 chr15:96890880 NA -0.47 -6.21 -0.32 1.53e-9 Schizophrenia; LUSC cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg18681998 chr4:17616180 MED28 0.81 13.83 0.6 1e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs890448 0.796 rs7698946 chr4:102358076 C/T cg05120309 chr14:100485494 NA -0.37 -6.04 -0.31 4.22e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg05340658 chr4:99064831 C4orf37 0.67 11.44 0.53 8.92e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.71 0.34 8.43e-11 Schizophrenia; LUSC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg08859206 chr1:53392774 SCP2 0.47 7.84 0.39 5.91e-14 Monocyte count; LUSC cis rs716316 1.000 rs716316 chr20:14908741 C/T cg04470754 chr20:14904432 MACROD2 0.49 8.38 0.42 1.52e-15 Advanced glycation end-product levels; LUSC cis rs9467711 0.606 rs12174639 chr6:26373121 G/A cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs732765 0.644 rs2268613 chr14:75408500 G/A cg06637938 chr14:75390232 RPS6KL1 0.58 6.92 0.35 2.33e-11 Non-small cell lung cancer; LUSC cis rs2011503 0.882 rs8108777 chr19:19359058 C/A cg11584989 chr19:19387371 SF4 0.62 7.39 0.38 1.16e-12 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11207300 chr12:95867190 METAP2 0.48 6.96 0.36 1.78e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11048434 0.723 rs2080116 chr12:9138183 A/G cg13575925 chr12:9217583 LOC144571 0.34 6.31 0.33 8.69e-10 Sjögren's syndrome; LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg17372223 chr3:52568218 NT5DC2 0.39 6.34 0.33 7.54e-10 Electroencephalogram traits; LUSC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg14019146 chr3:50243930 SLC38A3 -0.32 -7.0 -0.36 1.37e-11 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2425143 1.000 rs45595739 chr20:34320759 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.18 -0.32 1.83e-9 Blood protein levels; LUSC cis rs7851660 0.809 rs10512255 chr9:100652582 C/T cg13688889 chr9:100608707 NA -0.54 -7.72 -0.39 1.37e-13 Strep throat; LUSC trans rs9291683 0.595 rs3733585 chr4:10036339 A/G cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.01e-12 Bone mineral density; LUSC cis rs5756813 0.688 rs34891095 chr22:38126582 C/T cg06521852 chr22:38141419 TRIOBP 0.39 5.9 0.31 9.05e-9 Optic cup area;Vertical cup-disc ratio; LUSC cis rs75920871 0.528 rs7935913 chr11:116944348 A/G cg01368799 chr11:117014884 PAFAH1B2 0.51 6.62 0.34 1.44e-10 Subjective well-being; LUSC trans rs1814175 0.650 rs6486000 chr11:49659090 T/A cg03929089 chr4:120376271 NA -0.91 -15.0 -0.63 3.18e-39 Height; LUSC cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg24733560 chr20:60626293 TAF4 0.41 6.65 0.34 1.17e-10 Body mass index; LUSC cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.56e-23 Alzheimer's disease (late onset); LUSC cis rs568617 0.716 rs17854357 chr11:65601560 G/C cg04055107 chr11:65626734 MUS81;CFL1 0.63 6.97 0.36 1.72e-11 Crohn's disease; LUSC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg03806693 chr22:41940476 POLR3H 1.01 14.37 0.62 8.38e-37 Crohn's disease;Inflammatory bowel disease; LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg27094323 chr7:1216898 NA 0.37 6.56 0.34 2.07e-10 Longevity;Endometriosis; LUSC cis rs752010 0.619 rs10736421 chr1:42106230 G/A cg06885757 chr1:42089581 HIVEP3 0.59 11.96 0.55 1.1e-27 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg06238570 chr21:40685208 BRWD1 0.53 8.03 0.4 1.66e-14 Cognitive function; LUSC trans rs11098499 0.954 rs10017371 chr4:120293776 A/G cg25214090 chr10:38739885 LOC399744 0.55 7.8 0.39 8.24e-14 Corneal astigmatism; LUSC cis rs4363385 0.934 rs4240865 chr1:152954839 G/T cg00922841 chr1:152955080 SPRR1A 0.45 7.57 0.38 3.6e-13 Inflammatory skin disease; LUSC cis rs977987 0.778 rs4888412 chr16:75443196 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.61 -0.34 1.52e-10 Dupuytren's disease; LUSC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg11266682 chr4:10021025 SLC2A9 -0.48 -8.07 -0.4 1.31e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1113500 0.698 rs1781078 chr1:108591642 G/A cg06207961 chr1:108661230 NA -0.3 -5.65 -0.3 3.49e-8 Growth-regulated protein alpha levels; LUSC cis rs9325144 0.752 rs12300353 chr12:39154492 G/C cg26384229 chr12:38710491 ALG10B -0.6 -9.14 -0.45 6.34e-18 Morning vs. evening chronotype; LUSC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg17971929 chr21:40555470 PSMG1 -0.79 -13.61 -0.6 7.46e-34 Cognitive function; LUSC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg18230493 chr5:56204884 C5orf35 -0.71 -10.95 -0.51 4.86e-24 Coronary artery disease; LUSC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg06008330 chr7:65541103 ASL 0.4 6.24 0.32 1.34e-9 Aortic root size; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg16405210 chr4:1374714 KIAA1530 -0.54 -8.23 -0.41 4.36e-15 Obesity-related traits; LUSC cis rs6665290 0.904 rs6690803 chr1:227189106 C/T cg10327440 chr1:227177885 CDC42BPA -1.19 -38.77 -0.9 1.09e-125 Myeloid white cell count; LUSC cis rs77633900 0.772 rs387321 chr15:76743565 A/G cg21673338 chr15:77095150 SCAPER -0.7 -6.08 -0.32 3.24e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs34779708 0.931 rs34087268 chr10:35346724 T/G cg04310649 chr10:35416472 CREM -0.43 -6.55 -0.34 2.18e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg07701084 chr6:150067640 NUP43 0.56 8.51 0.42 6.04e-16 Lung cancer; LUSC cis rs10189230 0.967 rs13002861 chr2:222352859 T/G cg14652038 chr2:222343519 EPHA4 0.32 5.73 0.3 2.2e-8 Urate levels in lean individuals; LUSC trans rs895636 0.898 rs10205310 chr2:45188646 A/G cg14014731 chr9:19378679 RPS6 0.51 6.26 0.32 1.15e-9 Metabolite levels;Fasting plasma glucose; LUSC cis rs16917546 0.935 rs12766391 chr10:64441204 C/T cg03961010 chr10:64397487 ZNF365 -0.4 -6.28 -0.33 1.03e-9 Basal cell carcinoma; LUSC cis rs7542375 0.524 rs2807869 chr1:221094068 A/G cg16008148 chr1:221062819 NA 0.43 8.29 0.41 2.89e-15 Obesity-related traits; LUSC cis rs17102423 0.755 rs11625045 chr14:65549089 C/T cg11161011 chr14:65562177 MAX -0.8 -12.27 -0.56 8.2e-29 Obesity-related traits; LUSC cis rs6580649 0.941 rs6580651 chr12:48429933 A/T cg24011408 chr12:48396354 COL2A1 -0.46 -6.17 -0.32 1.95e-9 Lung cancer; LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg02475777 chr4:1388615 CRIPAK -0.42 -6.18 -0.32 1.87e-9 Obesity-related traits; LUSC cis rs8062405 0.679 rs72793818 chr16:28893137 G/A cg09754948 chr16:28834200 ATXN2L 0.42 6.02 0.31 4.62e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.89 0.48 2.14e-20 Bipolar disorder; LUSC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg13206674 chr6:150067644 NUP43 0.43 6.55 0.34 2.17e-10 Testicular germ cell tumor; LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg02018176 chr4:1364513 KIAA1530 0.52 9.13 0.45 6.57e-18 Obesity-related traits; LUSC cis rs12900413 0.603 rs12909833 chr15:90301518 G/A cg24249390 chr15:90295951 MESP1 -0.38 -5.93 -0.31 7.77e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.32 0.53 2.22e-25 Menopause (age at onset); LUSC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -18.91 -0.72 9.91e-55 Height; LUSC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.88 14.29 0.62 1.7e-36 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg12310025 chr6:25882481 NA 0.42 6.89 0.35 2.76e-11 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg17179660 chr6:151773299 C6orf211;RMND1 -0.47 -6.84 -0.35 3.77e-11 Menarche (age at onset); LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg03579872 chr1:53393473 SCP2 0.39 5.65 0.3 3.38e-8 Monocyte count; LUSC cis rs41271473 1.000 rs17352654 chr1:228878193 T/C cg16512390 chr1:228756714 NA 0.5 6.04 0.31 4.05e-9 Chronic lymphocytic leukemia; LUSC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 9.93 0.48 1.51e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs5750830 0.645 rs756640 chr22:39779300 G/A cg05872129 chr22:39784769 NA -0.58 -10.76 -0.51 2.14e-23 Intelligence (multi-trait analysis); LUSC cis rs11190604 0.943 rs11190588 chr10:102273565 C/T cg16342193 chr10:102329863 NA -0.39 -6.85 -0.35 3.56e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9788682 0.747 rs6495308 chr15:78907656 A/G cg06917634 chr15:78832804 PSMA4 -0.49 -6.51 -0.34 2.79e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs694739 0.734 rs663743 chr11:64107735 G/A cg02228329 chr11:64053129 BAD;GPR137 0.55 7.74 0.39 1.22e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg21918786 chr6:109611834 NA -0.44 -7.65 -0.39 2.22e-13 Reticulocyte fraction of red cells; LUSC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg08888203 chr3:10149979 C3orf24 0.57 8.06 0.4 1.33e-14 Alzheimer's disease; LUSC cis rs6977660 0.619 rs10950752 chr7:19781531 A/G cg07541023 chr7:19748670 TWISTNB 0.61 6.5 0.34 2.89e-10 Thyroid stimulating hormone; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.06 0.4 1.36e-14 Prudent dietary pattern; LUSC cis rs9359856 0.510 rs3736984 chr6:90408589 C/T cg13799429 chr6:90582589 CASP8AP2 0.96 11.58 0.54 2.69e-26 Bipolar disorder; LUSC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg26513180 chr16:89883248 FANCA 0.79 6.37 0.33 6.26e-10 Skin colour saturation; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg11062466 chr8:58055876 NA 0.72 8.93 0.44 2.94e-17 Developmental language disorder (linguistic errors); LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg11645453 chr3:52864694 ITIH4 0.35 8.17 0.41 6.58e-15 Bipolar disorder; LUSC cis rs8062405 1.000 rs12325113 chr16:28848668 T/C cg09754948 chr16:28834200 ATXN2L 0.41 5.86 0.31 1.13e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.81 0.43 7.02e-17 Prudent dietary pattern; LUSC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -6.51 -0.34 2.8e-10 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg18827107 chr12:86230957 RASSF9 -0.49 -7.29 -0.37 2.22e-12 Major depressive disorder; LUSC cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg25427524 chr10:38739819 LOC399744 0.45 7.4 0.38 1.13e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.35e-30 Motion sickness; LUSC cis rs7208859 0.623 rs3752021 chr17:29111043 G/C cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7582720 0.943 rs72926799 chr2:203828192 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg19318889 chr4:1322082 MAEA 0.81 14.74 0.63 3.17e-38 Longevity; LUSC cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg15839431 chr19:19639596 YJEFN3 0.44 6.11 0.32 2.85e-9 Tonsillectomy; LUSC cis rs259282 0.574 rs12610727 chr19:33116138 G/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.68 10.01 0.48 8.73e-21 Schizophrenia; LUSC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg12615879 chr12:58013172 SLC26A10 -0.27 -5.77 -0.3 1.78e-8 Multiple sclerosis; LUSC cis rs501916 0.604 rs616871 chr15:48058259 T/A cg16110827 chr15:48056943 SEMA6D -0.38 -5.9 -0.31 8.75e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC trans rs7786808 0.552 rs2878456 chr7:158182129 A/T cg02030672 chr11:45687055 CHST1 0.49 7.79 0.39 8.31e-14 Obesity-related traits; LUSC cis rs7246967 0.673 rs34676724 chr19:22918473 A/C cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs13089785 0.898 rs13062100 chr3:123674337 A/G cg02558132 chr3:123411198 MYLK 0.34 5.66 0.3 3.33e-8 Intelligence (multi-trait analysis); LUSC cis rs7727544 0.716 rs7701414 chr5:131585958 A/G cg14196790 chr5:131705035 SLC22A5 0.48 8.2 0.41 5.4e-15 Blood metabolite levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15711037 chr19:50379834 AKT1S1;TBC1D17 -0.4 -6.07 -0.32 3.38e-9 Electrocardiographic conduction measures; LUSC trans rs4942242 0.640 rs17538959 chr13:44229911 T/G cg19169023 chr15:41853346 TYRO3 -0.61 -9.01 -0.44 1.56e-17 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs8077577 0.945 rs8065026 chr17:18046290 A/G cg16794390 chr17:18148240 FLII 0.39 5.84 0.3 1.21e-8 Obesity-related traits; LUSC trans rs6502050 0.634 rs11077973 chr17:80095191 C/T cg07393940 chr7:158741817 NA 0.37 6.78 0.35 5.58e-11 Life satisfaction; LUSC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg06713675 chr4:122721982 EXOSC9 -0.72 -12.31 -0.56 5.85e-29 Type 2 diabetes; LUSC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg21951975 chr1:209979733 IRF6 0.61 7.89 0.4 4.43e-14 Cleft lip with or without cleft palate; LUSC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg24110177 chr3:50126178 RBM5 -0.64 -11.47 -0.53 6.53e-26 Body mass index; LUSC cis rs7582720 1.000 rs72934512 chr2:203926271 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg06552810 chr11:31128660 NA -0.42 -7.4 -0.38 1.09e-12 Red blood cell count; LUSC cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.51 -0.34 2.82e-10 Colorectal cancer; LUSC cis rs6121246 0.697 rs45557936 chr20:30226690 G/A cg13852791 chr20:30311386 BCL2L1 0.84 10.32 0.49 7.33e-22 Mean corpuscular hemoglobin; LUSC cis rs9300255 0.596 rs4460848 chr12:123677810 A/G cg00376283 chr12:123451042 ABCB9 0.69 9.71 0.47 8.35e-20 Neutrophil percentage of white cells; LUSC cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg14343924 chr8:8086146 FLJ10661 0.42 6.08 0.32 3.23e-9 Mood instability; LUSC cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg19230755 chr7:65878503 NA -0.42 -5.93 -0.31 7.43e-9 Aortic root size; LUSC cis rs3087591 0.683 rs2854306 chr17:29648146 G/A cg24425628 chr17:29625626 OMG;NF1 0.46 6.88 0.35 2.93e-11 Hip circumference; LUSC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg07926092 chr13:79233506 RNF219 0.49 5.84 0.3 1.24e-8 Large artery stroke; LUSC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs5758659 0.904 rs134877 chr22:42662371 C/T cg05082376 chr22:42548792 NA -0.39 -6.53 -0.34 2.43e-10 Cognitive function; LUSC cis rs9902453 0.845 rs3115101 chr17:28041627 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.39 0.46 9.91e-19 Coffee consumption (cups per day); LUSC cis rs6542838 0.611 rs17758170 chr2:99531842 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.07 -0.32 3.56e-9 Fear of minor pain; LUSC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg16680214 chr1:154839983 KCNN3 -0.55 -10.52 -0.5 1.49e-22 Prostate cancer; LUSC cis rs8060686 0.668 rs8048034 chr16:68210604 A/G cg26727032 chr16:67993705 SLC12A4 -0.4 -5.98 -0.31 5.79e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9814567 0.896 rs6794258 chr3:134344505 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -5.77 -0.3 1.84e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs2797160 1.000 rs2797158 chr6:126009398 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.86 0.35 3.34e-11 Endometrial cancer; LUSC cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1267303 0.642 rs116078607 chr1:46999238 G/A cg25110126 chr1:46999211 NA 0.77 11.11 0.52 1.28e-24 Monobrow; LUSC cis rs1348850 0.789 rs13027959 chr2:178275887 G/A cg22681709 chr2:178499509 PDE11A -0.51 -9.41 -0.46 8.58e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05901451 chr6:126070800 HEY2 0.6 9.11 0.45 7.58e-18 Endometrial cancer; LUSC cis rs72781680 0.652 rs12618900 chr2:23910775 C/T cg20701182 chr2:24300061 SF3B14 0.8 7.59 0.38 3.2e-13 Lymphocyte counts; LUSC cis rs9905704 0.633 rs72841019 chr17:56496346 G/A cg19466818 chr17:56409534 MIR142 -0.35 -6.39 -0.33 5.58e-10 Testicular germ cell tumor; LUSC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg23630131 chr7:65973040 NA -0.21 -5.82 -0.3 1.38e-8 Aortic root size; LUSC cis rs7246657 0.653 rs4805208 chr19:37674259 G/A cg23950597 chr19:37808831 NA -0.56 -5.66 -0.3 3.23e-8 Coronary artery calcification; LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC cis rs7572644 0.699 rs7577437 chr2:28168415 A/G cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2070488 0.662 rs7652475 chr3:38481341 C/T cg24069376 chr3:38537580 EXOG 0.35 6.29 0.33 9.81e-10 Electrocardiographic conduction measures; LUSC cis rs6500602 0.673 rs1861652 chr16:4505331 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 7.99 0.4 2.19e-14 Schizophrenia; LUSC trans rs2074977 0.530 rs10401784 chr19:3445721 A/C cg08382705 chr11:45687319 CHST1 -0.47 -7.21 -0.37 3.79e-12 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06957321 chr12:50236806 BCDIN3D -0.4 -6.01 -0.31 4.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7561273 0.586 rs4149372 chr2:24305512 T/G cg06627628 chr2:24431161 ITSN2 -0.51 -6.66 -0.34 1.12e-10 Quantitative traits; LUSC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg16425592 chr11:842748 TSPAN4;POLR2L -0.49 -6.95 -0.36 1.95e-11 Mean platelet volume; LUSC cis rs7927771 0.524 rs10838740 chr11:47679980 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.6 0.34 1.6e-10 Subjective well-being; LUSC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg22535103 chr8:58192502 C8orf71 -0.66 -7.44 -0.38 8.86e-13 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.788 rs2236449 chr21:46702506 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.69 10.41 0.49 3.71e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg23791538 chr6:167370224 RNASET2 0.42 6.79 0.35 5.12e-11 Crohn's disease; LUSC cis rs950169 0.840 rs62019457 chr15:85102142 T/C cg11189052 chr15:85197271 WDR73 0.47 5.8 0.3 1.56e-8 Schizophrenia; LUSC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg07343612 chr16:622815 PIGQ -0.73 -12.49 -0.56 1.22e-29 Height; LUSC cis rs12760731 0.623 rs12023044 chr1:178407772 G/A cg00404053 chr1:178313656 RASAL2 0.48 5.76 0.3 1.91e-8 Obesity-related traits; LUSC cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 7.16 0.36 5.32e-12 Platelet count; LUSC cis rs10791323 0.538 rs1105494 chr11:133698733 A/C cg15485101 chr11:133734466 NA -0.34 -5.83 -0.3 1.28e-8 Childhood ear infection; LUSC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs11625487 0.915 rs11845826 chr14:77966145 C/A cg20045696 chr14:77926864 AHSA1 0.43 5.79 0.3 1.61e-8 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; LUSC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg26597838 chr10:835615 NA 0.99 14.12 0.61 8.22e-36 Eosinophil percentage of granulocytes; LUSC cis rs11190604 1.000 rs3793706 chr10:102269085 A/C cg23241863 chr10:102295624 HIF1AN -0.48 -6.08 -0.32 3.26e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg04586622 chr2:25135609 ADCY3 0.44 9.24 0.45 2.86e-18 Body mass index; LUSC cis rs8067354 0.831 rs2333617 chr17:57896220 T/A cg02344993 chr17:57696989 CLTC -0.37 -5.65 -0.3 3.42e-8 Hemoglobin concentration; LUSC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg02609749 chr16:89786786 C16orf7;ZNF276 0.44 7.16 0.36 5.02e-12 Vitiligo; LUSC cis rs3771570 1.000 rs4675811 chr2:242402062 A/T cg21155796 chr2:242212141 HDLBP 0.5 6.02 0.31 4.49e-9 Prostate cancer; LUSC cis rs11051970 0.636 rs2733705 chr12:32561564 T/C cg24626660 chr12:32551988 NA 0.31 5.66 0.3 3.25e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11690935 0.632 rs12991740 chr2:172885996 C/T cg13550731 chr2:172543902 DYNC1I2 0.58 9.09 0.45 8.86e-18 Schizophrenia; LUSC cis rs6840360 0.571 rs718801 chr4:152549247 C/T cg22705602 chr4:152727874 NA -0.31 -6.09 -0.32 3.14e-9 Intelligence (multi-trait analysis); LUSC cis rs6736093 0.830 rs11680463 chr2:112775611 T/A cg12686935 chr2:112915763 FBLN7 -0.39 -6.24 -0.32 1.31e-9 Coronary artery disease; LUSC cis rs16854884 0.632 rs35716467 chr3:143684993 C/A cg06585982 chr3:143692056 C3orf58 0.49 7.62 0.38 2.6e-13 Economic and political preferences (feminism/equality); LUSC cis rs7523273 0.526 rs3849274 chr1:208021557 T/A cg22525895 chr1:207977042 MIR29B2 -0.37 -5.86 -0.31 1.12e-8 Schizophrenia; LUSC cis rs7312933 0.558 rs4768399 chr12:42742696 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.49 -6.8 -0.35 4.7e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21659725 chr3:3221576 CRBN 0.88 18.31 0.71 2.39e-52 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24715260 chr17:80056221 FASN -0.5 -5.95 -0.31 6.62e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.21 0.52 5.93e-25 Prudent dietary pattern; LUSC cis rs11696845 0.666 rs6073533 chr20:43361082 G/T cg25301532 chr20:43378953 KCNK15 -0.35 -6.48 -0.33 3.3e-10 Obesity-related traits; LUSC trans rs1256061 0.845 rs6573549 chr14:64721649 T/C cg07874507 chr10:24503148 KIAA1217 0.34 5.96 0.31 6.37e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs3749237 0.964 rs2352967 chr3:49871641 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.47 6.58 0.34 1.82e-10 Resting heart rate; LUSC cis rs208515 0.525 rs12193560 chr6:66690457 A/T cg07460842 chr6:66804631 NA 1.06 14.42 0.62 5.65e-37 Exhaled nitric oxide levels; LUSC cis rs9653442 0.511 rs6739695 chr2:100859622 A/G cg07810366 chr2:100720526 AFF3 -0.38 -6.19 -0.32 1.8e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg05535760 chr7:792225 HEATR2 0.81 9.46 0.46 5.76e-19 Cerebrospinal P-tau181p levels; LUSC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg15744005 chr10:104629667 AS3MT -0.4 -8.21 -0.41 4.9e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs57221529 0.766 rs72703070 chr5:590458 T/C cg25482853 chr8:67687455 SGK3 1.18 16.74 0.68 4.07e-46 Lung disease severity in cystic fibrosis; LUSC cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg24692254 chr21:30365293 RNF160 -0.89 -18.07 -0.7 2.11e-51 Dental caries; LUSC cis rs72634258 0.945 rs441597 chr1:8080895 A/G cg26816564 chr1:7831052 VAMP3 0.46 6.27 0.32 1.1e-9 Inflammatory bowel disease; LUSC cis rs473651 0.904 rs508274 chr2:239337723 G/A cg18131467 chr2:239335373 ASB1 1.04 25.8 0.82 1.72e-81 Multiple system atrophy; LUSC trans rs11098499 0.644 rs7676296 chr4:120555687 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.49 0.33 3.02e-10 Corneal astigmatism; LUSC cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.27 -0.32 1.11e-9 Bipolar disorder; LUSC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg25767906 chr1:53392781 SCP2 0.45 7.9 0.4 4.06e-14 Monocyte count; LUSC trans rs7937682 0.575 rs34695265 chr11:111719128 T/C cg18187862 chr3:45730750 SACM1L -0.5 -6.17 -0.32 1.95e-9 Primary sclerosing cholangitis; LUSC cis rs7615952 0.932 rs9841157 chr3:125635655 C/A cg05084668 chr3:125655381 ALG1L -0.8 -11.75 -0.54 6.33e-27 Blood pressure (smoking interaction); LUSC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg11062466 chr8:58055876 NA 0.7 8.73 0.43 1.26e-16 Developmental language disorder (linguistic errors); LUSC cis rs4845570 0.850 rs11204892 chr1:151768048 A/G cg07092448 chr1:151763213 TDRKH 1.26 16.6 0.67 1.47e-45 Coronary artery disease; LUSC cis rs1577917 0.771 rs2475790 chr6:86368068 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -10.84 -0.51 1.12e-23 Response to antipsychotic treatment; LUSC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.57 0.38 3.72e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs881375 0.967 rs876445 chr9:123677102 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.99 0.31 5.41e-9 Rheumatoid arthritis; LUSC cis rs6969780 1.000 rs929249 chr7:27167537 T/C cg26364809 chr7:27145159 NA -0.59 -5.89 -0.31 9.42e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs12618769 0.625 rs61180742 chr2:99148078 A/G cg10123293 chr2:99228465 UNC50 0.47 7.76 0.39 1.04e-13 Bipolar disorder; LUSC cis rs6489882 0.867 rs1859335 chr12:113367325 C/T cg20102336 chr12:113376681 OAS3 -0.42 -5.96 -0.31 6.39e-9 Chronic lymphocytic leukemia; LUSC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg24549020 chr5:56110836 MAP3K1 -0.48 -5.66 -0.3 3.23e-8 Initial pursuit acceleration; LUSC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg06637938 chr14:75390232 RPS6KL1 -0.54 -8.63 -0.43 2.55e-16 Coronary artery disease; LUSC cis rs907612 0.638 rs907613 chr11:1874292 G/A cg26158194 chr11:1874320 LSP1 0.37 6.76 0.35 6.02e-11 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs11250464 0.833 rs11250467 chr10:1409662 A/G cg08668359 chr10:1443807 ADARB2 0.41 6.2 0.32 1.66e-9 Radiation response; LUSC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg01346077 chr3:125931526 NA 0.31 5.79 0.3 1.62e-8 Metabolite levels; LUSC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -8.26 -0.41 3.57e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs2243480 1.000 rs1499613 chr7:65730860 G/A cg10756647 chr7:56101905 PSPH -0.87 -8.66 -0.43 2.02e-16 Diabetic kidney disease; LUSC cis rs1371867 0.846 rs1660351 chr8:101275034 C/T cg00191853 chr8:101177733 SPAG1 -0.36 -5.82 -0.3 1.38e-8 Atrioventricular conduction; LUSC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.44 8.53 0.42 5.14e-16 Autism spectrum disorder or schizophrenia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg03808149 chr6:10747832 TMEM14B 0.39 6.37 0.33 6.37e-10 Asthma; LUSC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.46e-10 Total body bone mineral density; LUSC cis rs12594515 0.967 rs71405295 chr15:45988921 T/C cg01629716 chr15:45996671 NA 0.4 6.06 0.31 3.68e-9 Waist circumference;Weight; LUSC cis rs6489785 0.643 rs2015462 chr12:121238204 G/C cg02419362 chr12:121203948 SPPL3 0.41 7.3 0.37 2.15e-12 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC cis rs17095355 1.000 rs17126890 chr10:111699169 T/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.6 -0.38 2.95e-13 Biliary atresia; LUSC cis rs7824557 0.628 rs7005469 chr8:11194457 G/A cg21775007 chr8:11205619 TDH 0.79 13.48 0.59 2.26e-33 Retinal vascular caliber; LUSC cis rs10875746 0.904 rs11168422 chr12:48519505 T/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.87 -0.31 1.07e-8 Longevity (90 years and older); LUSC cis rs4776059 0.550 rs73396766 chr15:52911516 C/T cg25063058 chr15:52860530 ARPP19 -0.54 -5.87 -0.31 1.04e-8 Schizophrenia; LUSC cis rs11229555 0.645 rs11229436 chr11:58186009 G/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs8062405 0.755 rs4787457 chr16:28555400 A/G cg16576597 chr16:28551801 NUPR1 0.34 6.73 0.35 7.35e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg14298792 chr15:30685198 CHRFAM7A 0.69 9.0 0.44 1.78e-17 Huntington's disease progression; LUSC cis rs1387259 0.929 rs11168484 chr12:48633589 A/C cg04545296 chr12:48745243 ZNF641 0.34 6.15 0.32 2.27e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs7712401 0.623 rs30032 chr5:122238387 G/T cg19077854 chr5:122220652 SNX24 0.39 8.23 0.41 4.14e-15 Mean platelet volume; LUSC cis rs12681288 0.550 rs4272405 chr8:959014 C/G cg15309053 chr8:964076 NA 0.43 8.82 0.43 6.26e-17 Schizophrenia; LUSC cis rs7106204 0.748 rs6484032 chr11:24237153 C/A ch.11.24196551F chr11:24239977 NA 1.16 14.62 0.62 8.9e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg03146154 chr1:46216737 IPP -0.5 -7.19 -0.37 4.3e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2742234 0.590 rs2293020 chr10:43692887 A/G cg15436174 chr10:43711423 RASGEF1A 0.43 7.0 0.36 1.38e-11 Hirschsprung disease; LUSC cis rs2012796 1.000 rs10450939 chr14:81825202 A/T cg02996355 chr14:81879375 NA 0.5 7.25 0.37 2.83e-12 Night sleep phenotypes; LUSC cis rs6076065 0.692 rs6083092 chr20:23348836 T/C cg11657817 chr20:23433608 CST11 0.43 8.01 0.4 1.88e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.82 0.35 4.23e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs17095355 1.000 rs11194920 chr10:111695412 G/T cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.96 -0.36 1.81e-11 Biliary atresia; LUSC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg08677398 chr8:58056175 NA 0.61 6.98 0.36 1.59e-11 Developmental language disorder (linguistic errors); LUSC trans rs17815608 1.000 rs17815571 chr12:77398434 C/T cg18631743 chr22:20104954 RANBP1;TRMT2A -0.59 -6.93 -0.35 2.17e-11 Type 2 diabetes; LUSC cis rs7223966 1.000 rs8080211 chr17:61729882 A/G cg05941027 chr17:61774174 LIMD2 0.23 5.93 0.31 7.7e-9 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs9329221 0.618 rs4314693 chr8:10258932 G/T cg15556689 chr8:8085844 FLJ10661 -0.5 -7.03 -0.36 1.18e-11 Neuroticism; LUSC cis rs12421382 0.592 rs2029297 chr11:109465968 A/G cg16359550 chr11:109292809 C11orf87 0.35 5.97 0.31 5.9e-9 Schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24340807 chr12:57853743 GLI1 0.44 6.78 0.35 5.54e-11 Triglycerides; LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.78 -0.3 1.68e-8 Platelet count; LUSC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.86 0.31 1.09e-8 Menopause (age at onset); LUSC cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg02175503 chr12:58329896 NA 0.48 6.9 0.35 2.68e-11 Intelligence (multi-trait analysis); LUSC cis rs16854884 0.584 rs59768870 chr3:143738366 G/A cg06585982 chr3:143692056 C3orf58 0.51 8.06 0.4 1.33e-14 Economic and political preferences (feminism/equality); LUSC trans rs11088226 0.681 rs2833899 chr21:33933263 T/C cg09050820 chr6:167586206 TCP10L2 0.74 9.55 0.46 2.82e-19 Gastritis; LUSC cis rs2932538 0.922 rs3790611 chr1:113067792 A/G cg22162597 chr1:113214053 CAPZA1 0.72 10.19 0.49 2.02e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.54 0.38 4.47e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg06064525 chr11:970664 AP2A2 -0.34 -6.88 -0.35 2.98e-11 Alzheimer's disease (late onset); LUSC cis rs7712401 0.601 rs246271 chr5:122212822 A/G cg19077854 chr5:122220652 SNX24 0.41 9.2 0.45 3.93e-18 Mean platelet volume; LUSC cis rs11608355 0.515 rs11610558 chr12:109925865 C/T cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC trans rs6762477 0.748 rs2073726 chr3:50223593 T/A cg21659725 chr3:3221576 CRBN -0.49 -7.42 -0.38 9.7e-13 Menarche (age at onset); LUSC cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs9315204 0.645 rs602133 chr13:33697449 C/T cg06602200 chr11:46412424 NA 0.32 6.05 0.31 3.78e-9 Intracranial aneurysm; LUSC cis rs738322 0.935 rs75387 chr22:38572057 C/T cg25457927 chr22:38595422 NA -0.42 -8.87 -0.44 4.61e-17 Cutaneous nevi; LUSC cis rs9325144 0.647 rs11168104 chr12:38857616 G/T cg26384229 chr12:38710491 ALG10B -0.6 -9.14 -0.45 6.29e-18 Morning vs. evening chronotype; LUSC trans rs61931739 1.000 rs11502817 chr12:34010676 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.86 -0.4 5.34e-14 Morning vs. evening chronotype; LUSC cis rs7772486 0.748 rs2748484 chr6:146333653 C/T cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 9.26e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.29 0.64 2.31e-40 Intelligence (multi-trait analysis); LUSC trans rs7824557 0.564 rs13268126 chr8:11230574 G/A cg08975724 chr8:8085496 FLJ10661 -0.45 -6.69 -0.34 9.7e-11 Retinal vascular caliber; LUSC cis rs1256061 0.654 rs1256031 chr14:64746179 C/T cg23250157 chr14:64679961 SYNE2 0.32 6.03 0.31 4.38e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs656319 0.674 rs1484639 chr8:9983224 T/G cg08975724 chr8:8085496 FLJ10661 0.43 6.2 0.32 1.7e-9 Myopia (pathological); LUSC cis rs9815354 1.000 rs73071329 chr3:41810539 G/A cg03022575 chr3:42003672 ULK4 0.55 6.17 0.32 2e-9 Pulse pressure;Diastolic blood pressure; LUSC cis rs12681287 0.752 rs10111095 chr8:87250984 T/C cg27223183 chr8:87520930 FAM82B -0.45 -5.69 -0.3 2.72e-8 Caudate activity during reward; LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.56 0.62 1.57e-37 Platelet count; LUSC cis rs60733400 0.782 rs4648564 chr1:2562169 C/T cg18854424 chr1:2615690 NA -0.51 -10.44 -0.5 2.96e-22 Multiple sclerosis; LUSC cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg09184832 chr6:79620586 NA -0.44 -7.18 -0.37 4.63e-12 Intelligence (multi-trait analysis); LUSC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC trans rs4729127 1.000 rs8180727 chr7:94011085 A/G cg14660007 chr13:78271894 SLAIN1 -0.5 -6.23 -0.32 1.4e-9 Intelligence; LUSC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.74 0.51 2.64e-23 Homoarginine levels; LUSC cis rs6964587 1.000 rs1859037 chr7:91568272 A/G cg22709100 chr7:91322751 NA -0.4 -5.83 -0.3 1.3e-8 Breast cancer; LUSC trans rs1547374 1.000 rs1547374 chr21:43778895 C/T cg09521743 chr10:75415752 SYNPO2L 0.4 6.46 0.33 3.65e-10 Pancreatic cancer; LUSC cis rs13256369 0.802 rs34762800 chr8:8559294 G/A cg00074818 chr8:8560427 CLDN23 0.59 9.56 0.46 2.63e-19 Obesity-related traits; LUSC cis rs10927875 0.632 rs6677321 chr1:16149301 A/C cg21385522 chr1:16154831 NA -1.02 -20.42 -0.75 1.04e-60 Dilated cardiomyopathy; LUSC cis rs4889855 0.614 rs7221663 chr17:78484166 T/C cg16591659 chr17:78472290 NA -0.48 -7.83 -0.39 6.57e-14 Fractional excretion of uric acid; LUSC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg02551604 chr5:131831745 NA -0.41 -6.47 -0.33 3.5e-10 Asthma (sex interaction); LUSC cis rs9311676 0.656 rs11718352 chr3:58401480 G/A cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs7089973 0.604 rs2420066 chr10:116583897 A/G cg25233709 chr10:116636983 FAM160B1 0.38 6.63 0.34 1.38e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs1325195 0.537 rs2793805 chr1:179195777 A/G cg11624085 chr17:8464688 MYH10 0.43 6.38 0.33 5.94e-10 IgE grass sensitization; LUSC cis rs4737010 0.501 rs1579274 chr8:41658923 T/G cg08923054 chr8:41654455 ANK1 0.35 6.19 0.32 1.75e-9 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg13395646 chr4:1353034 KIAA1530 -0.62 -10.04 -0.48 6.69e-21 Obesity-related traits; LUSC cis rs308403 0.568 rs13138520 chr4:123675483 C/G cg10495464 chr4:123653540 BBS12;LOC729338 0.79 9.88 0.48 2.3e-20 Blood protein levels; LUSC cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg23711669 chr6:146136114 FBXO30 0.91 17.21 0.69 5.62e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs4845570 1.000 rs6659705 chr1:151769750 T/C cg07092448 chr1:151763213 TDRKH -1.27 -15.07 -0.64 1.68e-39 Coronary artery disease; LUSC cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.5 7.03 0.36 1.18e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9644630 0.696 rs13261824 chr8:19313912 C/G cg06562184 chr8:19319451 CSGALNACT1 0.49 8.25 0.41 3.62e-15 Oropharynx cancer; LUSC cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.5 6.79 0.35 5.16e-11 Cognitive ability; LUSC cis rs898097 0.625 rs2125479 chr17:80890262 A/G cg15664640 chr17:80829946 TBCD -0.45 -8.02 -0.4 1.76e-14 Breast cancer; LUSC cis rs2692947 0.860 rs2579520 chr2:96660300 C/T cg22654517 chr2:96458247 NA -0.32 -6.58 -0.34 1.77e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs12760731 0.623 rs6688546 chr1:178332511 A/G cg00404053 chr1:178313656 RASAL2 0.47 5.75 0.3 2.03e-8 Obesity-related traits; LUSC cis rs9815354 1.000 rs56121764 chr3:41883975 T/C cg03022575 chr3:42003672 ULK4 0.64 7.02 0.36 1.21e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.29 -0.33 9.79e-10 Total body bone mineral density; LUSC cis rs10761482 0.813 rs12776510 chr10:62167928 C/T cg18175470 chr10:62150864 ANK3 -0.57 -8.46 -0.42 8.62e-16 Schizophrenia; LUSC cis rs2639990 1.000 rs632157 chr18:72911548 G/A cg03972071 chr18:72917163 ZADH2 0.5 5.82 0.3 1.39e-8 Vascular endothelial growth factor levels; LUSC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.54 -0.38 4.33e-13 Blood metabolite levels; LUSC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg23711669 chr6:146136114 FBXO30 0.9 17.33 0.69 1.89e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21545467 chr11:124543651 SIAE;SPA17 0.41 6.07 0.32 3.54e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg11752832 chr7:134001865 SLC35B4 0.55 8.64 0.43 2.45e-16 Mean platelet volume; LUSC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg11502198 chr6:26597334 ABT1 0.7 11.69 0.54 1.07e-26 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.580 rs7395515 chr11:1005160 C/T cg06064525 chr11:970664 AP2A2 -0.29 -5.83 -0.3 1.33e-8 Alzheimer's disease (late onset); LUSC cis rs73206853 0.764 rs55913108 chr12:110816507 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.78 11.86 0.54 2.59e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.14 16.34 0.67 1.69e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs1923243 0.546 rs11210226 chr1:73854284 A/G cg18358762 chr2:73298974 SFXN5 -0.41 -6.15 -0.32 2.2e-9 Migraine; LUSC cis rs7586879 0.521 rs7597332 chr2:25075675 A/G cg15423357 chr2:25149977 NA 0.33 6.42 0.33 4.67e-10 Body mass index; LUSC cis rs751728 0.965 rs2296743 chr6:33740025 C/T cg25922239 chr6:33757077 LEMD2 0.53 7.91 0.4 3.84e-14 Crohn's disease; LUSC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg06600287 chr1:53387719 ECHDC2 -0.29 -5.75 -0.3 2e-8 Monocyte count; LUSC cis rs227833 0.826 rs4714813 chr6:44709890 C/A cg20913747 chr6:44695427 NA 0.4 6.26 0.32 1.15e-9 Monobrow; LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.27 -0.32 1.1e-9 Bipolar disorder and schizophrenia; LUSC cis rs117352156 0.943 rs10826542 chr10:29220419 C/A cg06394621 chr10:29236369 NA -0.45 -5.91 -0.31 8.29e-9 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg02569458 chr12:86230093 RASSF9 -0.49 -8.25 -0.41 3.64e-15 Major depressive disorder; LUSC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg03526776 chr6:41159608 TREML2 0.32 6.07 0.32 3.44e-9 Alzheimer's disease (late onset); LUSC cis rs6429082 0.667 rs10802800 chr1:235706283 A/G cg26050004 chr1:235667680 B3GALNT2 -0.46 -5.94 -0.31 7.32e-9 Adiposity; LUSC cis rs10170846 0.731 rs10180632 chr2:223526384 G/A cg25565276 chr2:223520875 FARSB 0.64 9.7 0.47 9.46e-20 Schizophrenia (inflammation and infection response interaction); LUSC cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg27446573 chr6:127587934 RNF146 -0.86 -13.81 -0.6 1.23e-34 Breast cancer; LUSC cis rs6940638 1.000 rs6940638 chr6:27046250 A/G cg05738196 chr6:26577821 NA -0.5 -5.79 -0.3 1.66e-8 Intelligence (multi-trait analysis); LUSC cis rs2842992 0.747 rs4709378 chr6:160227435 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.71 8.7 0.43 1.54e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg01097406 chr16:89675127 NA -0.34 -6.7 -0.34 8.66e-11 Vitiligo; LUSC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg23711669 chr6:146136114 FBXO30 0.77 12.55 0.57 7.37e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg04362960 chr10:104952993 NT5C2 0.59 9.4 0.46 9.13e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs921665 0.831 rs4402798 chr2:3190969 G/A cg02624386 chr2:3182749 NA 0.51 5.81 0.3 1.46e-8 World class endurance athleticism; LUSC cis rs7520050 0.897 rs4440807 chr1:46470878 T/C cg06784218 chr1:46089804 CCDC17 -0.29 -5.69 -0.3 2.78e-8 Red blood cell count;Reticulocyte count; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg03354898 chr7:1950403 MAD1L1 -0.45 -9.32 -0.45 1.63e-18 Bipolar disorder and schizophrenia; LUSC cis rs9300255 0.602 rs1106240 chr12:123626982 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.4 -5.95 -0.31 6.7e-9 Neutrophil percentage of white cells; LUSC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg27432699 chr2:27873401 GPN1 -0.58 -8.68 -0.43 1.72e-16 Total body bone mineral density; LUSC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg11645453 chr3:52864694 ITIH4 0.34 7.84 0.39 6.19e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg05527609 chr1:210001259 C1orf107 -0.4 -5.95 -0.31 6.73e-9 Monobrow; LUSC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.68 -9.58 -0.46 2.3e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg10729496 chr3:10149963 C3orf24 0.58 7.69 0.39 1.61e-13 Alzheimer's disease; LUSC cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg23711669 chr6:146136114 FBXO30 0.76 13.53 0.6 1.43e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.99 -0.36 1.54e-11 Lung cancer; LUSC cis rs9875589 0.509 rs1488377 chr3:14073178 C/G cg19554555 chr3:13937349 NA -0.42 -6.13 -0.32 2.53e-9 Ovarian reserve; LUSC cis rs9611519 0.929 rs12484971 chr22:41439304 A/T cg13813247 chr22:41461852 NA -0.37 -6.75 -0.35 6.38e-11 Neuroticism; LUSC cis rs11030122 0.673 rs4910590 chr11:4018619 C/T cg18678763 chr11:4115507 RRM1 -0.47 -6.19 -0.32 1.79e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs10782582 0.593 rs11801414 chr1:76124517 G/A cg22875332 chr1:76189707 ACADM -0.42 -6.24 -0.32 1.35e-9 Daytime sleep phenotypes; LUSC cis rs77106637 0.769 rs11603313 chr11:72588177 G/A cg04827223 chr11:72435913 ARAP1 -0.66 -8.5 -0.42 6.6e-16 Type 2 diabetes; LUSC cis rs17270561 0.636 rs1165216 chr6:25797971 G/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.29 0.37 2.22e-12 Iron status biomarkers; LUSC cis rs3087591 0.960 rs9303642 chr17:29578360 A/G cg24425628 chr17:29625626 OMG;NF1 -0.57 -8.54 -0.42 4.83e-16 Hip circumference; LUSC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg16049864 chr8:95962084 TP53INP1 -0.73 -14.1 -0.61 9.54e-36 Type 2 diabetes; LUSC cis rs35146811 0.700 rs866500 chr7:99840461 A/G cg22906224 chr7:99728672 NA -0.47 -6.04 -0.31 4.2e-9 Coronary artery disease; LUSC cis rs11764590 0.694 rs7801349 chr7:2085553 T/C cg19629631 chr7:2060116 MAD1L1 -0.34 -5.68 -0.3 2.89e-8 Neuroticism; LUSC cis rs73206853 0.841 rs57299791 chr12:110954021 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 7.83e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.21 0.59 2.34e-32 Total body bone mineral density; LUSC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg09877947 chr5:131593287 PDLIM4 -0.41 -6.78 -0.35 5.36e-11 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08409451 chr16:2273123 E4F1 0.41 6.61 0.34 1.56e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg08470875 chr2:26401718 FAM59B -0.66 -9.05 -0.44 1.19e-17 Gut microbiome composition (summer); LUSC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs7119038 0.818 rs10892287 chr11:118642999 C/T cg19308663 chr11:118741387 NA -0.33 -5.89 -0.31 9.24e-9 Sjögren's syndrome; LUSC cis rs9309473 0.500 rs2421582 chr2:73898420 A/G cg20560298 chr2:73613845 ALMS1 0.48 7.17 0.37 4.99e-12 Metabolite levels; LUSC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg17264618 chr3:40429014 ENTPD3 0.36 7.52 0.38 5.26e-13 Renal cell carcinoma; LUSC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg23750338 chr8:142222470 SLC45A4 0.47 9.04 0.44 1.34e-17 Immature fraction of reticulocytes; LUSC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg13047869 chr3:10149882 C3orf24 0.59 7.75 0.39 1.13e-13 Alzheimer's disease; LUSC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg02380750 chr20:61661411 NA 0.34 5.86 0.31 1.11e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg09650180 chr20:62225654 GMEB2 -0.68 -9.77 -0.47 5.51e-20 Glioblastoma; LUSC cis rs6087771 0.747 rs6058261 chr20:30235470 C/A cg21427119 chr20:30132790 HM13 -0.37 -5.98 -0.31 5.71e-9 Subcortical brain region volumes;Putamen volume; LUSC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg13206674 chr6:150067644 NUP43 0.49 7.38 0.37 1.3e-12 Lung cancer; LUSC cis rs11690935 0.589 rs62182403 chr2:172747182 G/A cg13550731 chr2:172543902 DYNC1I2 0.5 7.42 0.38 9.91e-13 Schizophrenia; LUSC cis rs752010 0.574 rs10890157 chr1:42117689 C/G cg06885757 chr1:42089581 HIVEP3 0.44 9.05 0.44 1.25e-17 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs1580019 0.922 rs766658 chr7:32499391 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.79 11.9 0.55 1.79e-27 Cognitive ability; LUSC cis rs79976124 0.877 rs79507557 chr6:66640908 C/A cg07460842 chr6:66804631 NA 0.72 9.03 0.44 1.38e-17 Type 2 diabetes; LUSC cis rs6901250 0.744 rs636872 chr6:117087944 C/T cg12892004 chr6:117198278 RFX6 0.41 7.36 0.37 1.45e-12 C-reactive protein levels; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg08736216 chr1:53307985 ZYG11A -0.27 -5.7 -0.3 2.68e-8 Monocyte count; LUSC cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg17420585 chr12:42539391 GXYLT1 -0.37 -7.15 -0.36 5.34e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg23583168 chr7:148888333 NA -0.91 -17.45 -0.69 6.14e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg24768116 chr2:27665128 KRTCAP3 -0.29 -5.68 -0.3 2.92e-8 Total body bone mineral density; LUSC cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC trans rs9291683 0.609 rs34709913 chr4:10028955 T/C cg26043149 chr18:55253948 FECH 0.51 7.52 0.38 5.09e-13 Bone mineral density; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg02951883 chr7:2050386 MAD1L1 -0.47 -8.02 -0.4 1.8e-14 Bipolar disorder and schizophrenia; LUSC cis rs4888262 0.508 rs4462623 chr16:74692426 C/T cg01733217 chr16:74700730 RFWD3 0.79 13.19 0.59 2.83e-32 Testicular germ cell tumor; LUSC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg03233332 chr7:66118400 NA 0.42 6.1 0.32 2.91e-9 Aortic root size; LUSC cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg17366294 chr4:99064904 C4orf37 0.54 9.28 0.45 2.14e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg04155289 chr7:94953770 PON1 -0.34 -5.77 -0.3 1.76e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9303280 0.806 rs8069176 chr17:38057197 G/A cg19468946 chr17:37922297 IKZF3 -0.44 -6.91 -0.35 2.54e-11 Self-reported allergy; LUSC cis rs2172802 0.660 rs10001410 chr4:62474229 C/A cg04118610 chr4:62707027 LPHN3 0.44 5.84 0.3 1.23e-8 Partial epilepsies; LUSC cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg05472934 chr7:22766657 IL6 0.38 6.05 0.31 3.94e-9 Lung cancer; LUSC cis rs7647973 0.593 rs62262730 chr3:49808274 T/G cg03060546 chr3:49711283 APEH -0.63 -7.27 -0.37 2.56e-12 Menarche (age at onset); LUSC cis rs4664304 0.742 rs67017730 chr2:160732793 T/G cg03641300 chr2:160917029 PLA2R1 -0.35 -5.67 -0.3 3.06e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2658782 0.756 rs2658777 chr11:93148423 C/T cg15737290 chr11:93063684 CCDC67 0.64 7.99 0.4 2.17e-14 Pulmonary function decline; LUSC cis rs734999 0.967 rs10797433 chr1:2502010 T/C cg18854424 chr1:2615690 NA 0.47 9.69 0.47 1.01e-19 Ulcerative colitis; LUSC cis rs12548874 0.607 rs12543492 chr8:95891843 C/A cg13393036 chr8:95962371 TP53INP1 -0.4 -8.43 -0.42 1.07e-15 Hemoglobin concentration; LUSC cis rs950881 0.562 rs11692335 chr2:103077893 C/T cg20060108 chr2:102954350 IL1RL1 0.45 6.18 0.32 1.91e-9 Allergy; LUSC cis rs7937682 0.889 rs7926485 chr11:111536670 G/A cg19812747 chr11:111475976 SIK2 -0.49 -6.99 -0.36 1.52e-11 Primary sclerosing cholangitis; LUSC trans rs2243480 1.000 rs781149 chr7:65481284 C/T cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.59e-15 Diabetic kidney disease; LUSC cis rs28735056 0.609 rs4799099 chr18:77639585 A/G cg03282975 chr18:77638264 KCNG2 -0.32 -5.65 -0.3 3.44e-8 Schizophrenia; LUSC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg22800045 chr5:56110881 MAP3K1 0.78 9.7 0.47 9.52e-20 Initial pursuit acceleration; LUSC cis rs7296418 0.699 rs1109559 chr12:123757861 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.61 -0.34 1.55e-10 Platelet count; LUSC cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg01884057 chr2:25150051 NA 0.48 11.43 0.53 9.16e-26 Body mass index; LUSC cis rs6665290 0.904 rs10916075 chr1:227184074 G/A cg10327440 chr1:227177885 CDC42BPA -1.21 -39.71 -0.91 1.49e-128 Myeloid white cell count; LUSC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg03806693 chr22:41940476 POLR3H -0.88 -12.74 -0.57 1.45e-30 Vitiligo; LUSC cis rs6500602 1.000 rs6500602 chr16:4497451 T/C cg08645402 chr16:4508243 NA 0.53 8.69 0.43 1.6e-16 Schizophrenia; LUSC cis rs4474465 1.000 rs4945281 chr11:78188627 C/G cg27205649 chr11:78285834 NARS2 -0.48 -5.72 -0.3 2.38e-8 Alzheimer's disease (survival time); LUSC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg04362960 chr10:104952993 NT5C2 0.59 9.33 0.45 1.51e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs713587 0.875 rs6746013 chr2:25143649 C/G cg01884057 chr2:25150051 NA 0.49 11.58 0.54 2.59e-26 Body mass index in non-asthmatics; LUSC cis rs76935404 0.811 rs11083589 chr19:41428416 A/T cg04176888 chr19:41596066 CYP2A13 0.38 6.06 0.31 3.59e-9 nicotine metabolite ratio in current smokers; LUSC trans rs11098499 0.913 rs13126596 chr4:120140729 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.37 0.33 6.42e-10 Corneal astigmatism; LUSC cis rs11098499 0.913 rs68128210 chr4:120137819 T/G cg09307838 chr4:120376055 NA 0.68 9.74 0.47 6.64e-20 Corneal astigmatism; LUSC cis rs826838 0.586 rs10880753 chr12:38628147 C/A cg13010199 chr12:38710504 ALG10B -0.45 -6.76 -0.35 6.24e-11 Heart rate; LUSC cis rs3755132 0.778 rs4668953 chr2:15785856 T/C cg12888861 chr2:15731646 DDX1 0.53 7.54 0.38 4.42e-13 Wilms tumor; LUSC cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg06026331 chr20:60912101 LAMA5 -0.46 -6.21 -0.32 1.6e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg24550644 chr17:30846204 MYO1D -0.44 -7.06 -0.36 9.51e-12 Schizophrenia; LUSC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg21545522 chr1:205238299 TMCC2 -0.5 -9.37 -0.46 1.15e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg02475777 chr4:1388615 CRIPAK -0.43 -6.3 -0.33 9.62e-10 Obesity-related traits; LUSC cis rs7799006 0.929 rs71525363 chr7:2268792 G/A cg08027265 chr7:2291960 NA -0.46 -7.75 -0.39 1.12e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg09455208 chr3:40491958 NA 0.58 10.2 0.49 1.96e-21 Renal cell carcinoma; LUSC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.76 0.35 6.2e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg10645314 chr2:3704589 ALLC -0.49 -7.33 -0.37 1.72e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs317689 0.690 rs547827 chr12:69669703 G/A cg20891283 chr12:69753455 YEATS4 0.45 5.97 0.31 6.19e-9 Response to diuretic therapy; LUSC cis rs1008375 1.000 rs12648232 chr4:17612537 C/T cg18681998 chr4:17616180 MED28 -0.79 -13.36 -0.59 6.56e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7824557 0.872 rs2572431 chr8:11105077 C/T cg06636001 chr8:8085503 FLJ10661 -0.58 -8.88 -0.44 4.03e-17 Retinal vascular caliber; LUSC cis rs11641365 0.517 rs73262667 chr16:88779753 C/T cg00034003 chr16:88779146 CTU2 0.75 8.22 0.41 4.65e-15 Autism spectrum disorder-related traits; LUSC cis rs3540 0.512 rs8033595 chr15:91083353 G/A cg22089800 chr15:90895588 ZNF774 -0.65 -10.12 -0.48 3.58e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg18129178 chr5:148520854 ABLIM3 -0.73 -10.54 -0.5 1.27e-22 Breast cancer; LUSC cis rs3820928 0.904 rs4414671 chr2:227816200 T/A cg11843606 chr2:227700838 RHBDD1 -0.55 -8.03 -0.4 1.67e-14 Pulmonary function; LUSC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs17373728 0.739 rs7835101 chr8:76169185 T/C cg07016329 chr8:76221503 NA -0.49 -6.98 -0.36 1.57e-11 Diabetic kidney disease; LUSC cis rs9323205 0.861 rs55763867 chr14:51608567 G/A cg23942311 chr14:51606299 NA -0.5 -10.18 -0.49 2.19e-21 Cancer; LUSC cis rs61931739 0.500 rs12367292 chr12:33998075 T/C cg06521331 chr12:34319734 NA -0.46 -7.33 -0.37 1.73e-12 Morning vs. evening chronotype; LUSC trans rs7819412 0.668 rs2409714 chr8:11010118 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.19 -0.32 1.78e-9 Triglycerides; LUSC cis rs7584330 0.518 rs77789507 chr2:238440972 C/T cg14458575 chr2:238380390 NA 0.59 6.82 0.35 4.29e-11 Prostate cancer; LUSC cis rs1023500 0.573 rs133378 chr22:42467695 G/C cg04733989 chr22:42467013 NAGA 0.61 9.41 0.46 8.37e-19 Schizophrenia; LUSC cis rs13064411 0.696 rs11921931 chr3:113015091 G/A cg18753928 chr3:113234510 CCDC52 -0.41 -5.87 -0.31 1.06e-8 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs62229266 0.804 rs62230822 chr21:37429945 T/C cg12218747 chr21:37451666 NA -0.38 -5.68 -0.3 2.97e-8 Mitral valve prolapse; LUSC trans rs11743006 0.626 rs13361324 chr5:136507512 G/C cg07379741 chr17:7311030 NLGN2 0.41 6.28 0.32 1.05e-9 Mathematical ability; LUSC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg16329197 chr12:53359506 NA -0.54 -8.0 -0.4 2e-14 Prostate cancer; LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.91 -0.31 8.51e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.53 -8.04 -0.4 1.62e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg12553538 chr17:8191987 RANGRF;SLC25A35 -0.36 -6.19 -0.32 1.76e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg09034736 chr1:150693464 HORMAD1 0.47 6.76 0.35 6.03e-11 Melanoma; LUSC trans rs853679 0.517 rs9393890 chr6:28063855 C/T cg06606381 chr12:133084897 FBRSL1 -0.45 -6.06 -0.31 3.67e-9 Depression; LUSC cis rs7267979 1.000 rs2500443 chr20:25331442 C/T cg08601574 chr20:25228251 PYGB -0.44 -6.8 -0.35 4.83e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg09796270 chr17:17721594 SREBF1 0.43 7.43 0.38 9.19e-13 Total body bone mineral density; LUSC cis rs8014204 0.816 rs4903262 chr14:75340818 A/G cg08847533 chr14:75593920 NEK9 0.39 5.67 0.3 3.12e-8 Caffeine consumption; LUSC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.63 0.5 6.24e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12421382 0.614 rs11213104 chr11:109391297 G/T cg16359550 chr11:109292809 C11orf87 0.32 5.65 0.3 3.38e-8 Schizophrenia; LUSC cis rs10752881 1.000 rs6701400 chr1:182977197 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg07828024 chr6:149772892 ZC3H12D -0.33 -7.36 -0.37 1.4e-12 Dupuytren's disease; LUSC cis rs7607369 0.637 rs3888879 chr2:219290676 C/T cg02176678 chr2:219576539 TTLL4 -0.71 -11.87 -0.54 2.41e-27 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -10.73 -0.51 2.83e-23 Bipolar disorder and schizophrenia; LUSC cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg26116260 chr4:7069785 GRPEL1 -1.14 -14.53 -0.62 2.07e-37 Monocyte percentage of white cells; LUSC cis rs9527 0.590 rs726010 chr10:104841977 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.74 -0.35 6.98e-11 Arsenic metabolism; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg09775780 chr17:18585893 ZNF286B -0.5 -6.81 -0.35 4.63e-11 Hepatitis; LUSC cis rs4595586 0.545 rs11615700 chr12:39365104 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.1 0.32 2.93e-9 Morning vs. evening chronotype; LUSC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg13072238 chr3:49761600 GMPPB 0.66 8.7 0.43 1.53e-16 Menarche (age at onset); LUSC cis rs2404602 0.692 rs34181263 chr15:77065388 C/T cg26408565 chr15:76604113 ETFA -0.49 -7.9 -0.4 3.99e-14 Blood metabolite levels; LUSC cis rs709400 0.567 rs1961600 chr14:103862144 G/A cg12935359 chr14:103987150 CKB -0.55 -8.44 -0.42 9.86e-16 Body mass index; LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.65 0.39 2.2e-13 Prudent dietary pattern; LUSC cis rs847577 0.609 rs705308 chr7:97695363 C/A cg21770322 chr7:97807741 LMTK2 -0.55 -9.9 -0.48 1.97e-20 Breast cancer; LUSC cis rs9388451 0.839 rs9401845 chr6:126104118 A/G cg05901451 chr6:126070800 HEY2 -0.95 -18.47 -0.71 5.31e-53 Brugada syndrome; LUSC cis rs7824557 0.767 rs11250127 chr8:11170209 G/A cg21775007 chr8:11205619 TDH 0.73 11.84 0.54 3.02e-27 Retinal vascular caliber; LUSC cis rs2439831 0.681 rs3742969 chr15:43621947 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.35 0.49 6.03e-22 Lung cancer in ever smokers; LUSC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg27532560 chr4:187881888 NA -0.37 -6.01 -0.31 4.85e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs2455601 0.744 rs7938995 chr11:8975675 T/G cg09997546 chr11:8931473 C11orf17;ST5 -0.46 -8.06 -0.4 1.38e-14 Schizophrenia; LUSC cis rs897080 0.515 rs1067319 chr2:44633458 A/G cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs12476592 0.602 rs10865339 chr2:63811884 G/T cg10828910 chr2:63850056 LOC388955 0.48 5.69 0.3 2.77e-8 Childhood ear infection; LUSC cis rs611744 0.625 rs11991891 chr8:109294858 G/A cg21045802 chr8:109455806 TTC35 0.49 7.69 0.39 1.62e-13 Dupuytren's disease; LUSC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg18230493 chr5:56204884 C5orf35 -0.88 -13.23 -0.59 2.03e-32 Initial pursuit acceleration; LUSC cis rs9399135 0.933 rs4559100 chr6:135324085 T/C cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Red blood cell count; LUSC cis rs12210905 0.925 rs10946896 chr6:26988576 A/G cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs600231 0.577 rs12269965 chr11:65232087 C/T cg17120908 chr11:65337727 SSSCA1 -0.62 -9.01 -0.44 1.61e-17 Bone mineral density; LUSC cis rs3774749 0.565 rs2624839 chr3:50202231 T/C cg14019146 chr3:50243930 SLC38A3 -0.44 -9.97 -0.48 1.14e-20 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg03213289 chr20:61660250 NA 0.68 14.14 0.61 6.77e-36 Prostate cancer (SNP x SNP interaction); LUSC cis rs3806843 0.576 rs246028 chr5:140333513 C/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs61931739 0.500 rs12832312 chr12:34031199 G/A cg13010199 chr12:38710504 ALG10B 0.55 8.37 0.42 1.63e-15 Morning vs. evening chronotype; LUSC cis rs34891900 0.507 rs1008378 chr22:18207251 T/C cg08824373 chr22:18117835 NA -0.39 -5.88 -0.31 9.82e-9 Sum neutrophil eosinophil counts; LUSC cis rs7811142 0.830 rs118119933 chr7:99939050 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 14.3 0.62 1.57e-36 Platelet count; LUSC cis rs5769707 0.681 rs2319346 chr22:50029640 A/G cg05373962 chr22:49881684 NA -0.4 -8.28 -0.41 3.1e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7246967 0.673 rs2194112 chr19:22926189 A/C cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs10876993 0.890 rs1092472 chr12:58036688 G/T cg15848620 chr12:58087721 OS9 -0.53 -7.47 -0.38 6.89e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs3808502 0.549 rs11991139 chr8:11428395 C/T cg27411982 chr8:10470053 RP1L1 -0.46 -7.1 -0.36 7.52e-12 Neuroticism; LUSC cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg00033643 chr7:134001901 SLC35B4 0.42 6.17 0.32 2e-9 Mean platelet volume; LUSC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg06108461 chr20:60628389 TAF4 -1.02 -17.12 -0.68 1.27e-47 Body mass index; LUSC cis rs4319547 0.695 rs12314643 chr12:122917423 C/T cg05707623 chr12:122985044 ZCCHC8 -0.63 -8.12 -0.41 9.37e-15 Body mass index; LUSC cis rs2742234 0.911 rs3004214 chr10:43631698 C/T cg15436174 chr10:43711423 RASGEF1A -0.46 -7.75 -0.39 1.08e-13 Hirschsprung disease; LUSC cis rs9486715 1.000 rs11153085 chr6:97066355 A/T cg06623918 chr6:96969491 KIAA0776 -0.85 -14.16 -0.61 5.78e-36 Headache; LUSC trans rs7824557 0.602 rs35807737 chr8:11204411 C/G cg08975724 chr8:8085496 FLJ10661 0.43 6.09 0.32 3.06e-9 Retinal vascular caliber; LUSC cis rs870825 0.860 rs72689295 chr4:185600930 T/C cg04058563 chr4:185651563 MLF1IP 0.83 11.65 0.54 1.45e-26 Blood protein levels; LUSC cis rs5750830 0.594 rs5757648 chr22:39775156 G/A cg02038168 chr22:39784481 NA -0.48 -7.72 -0.39 1.35e-13 Intelligence (multi-trait analysis); LUSC cis rs7208859 0.623 rs8080882 chr17:29081146 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs5758659 1.000 rs134869 chr22:42652074 G/A cg04733989 chr22:42467013 NAGA 0.41 6.5 0.34 2.89e-10 Cognitive function; LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg08736216 chr1:53307985 ZYG11A -0.28 -5.74 -0.3 2.14e-8 Monocyte count; LUSC cis rs7824557 0.767 rs2164272 chr8:11162496 A/C cg21293242 chr8:11204541 TDH 0.32 5.96 0.31 6.38e-9 Retinal vascular caliber; LUSC cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg21433313 chr16:3507492 NAT15 0.41 5.84 0.3 1.22e-8 Body mass index (adult); LUSC trans rs975730 0.801 rs6998301 chr8:129435018 A/G cg06138505 chr3:127317209 MCM2 0.36 6.17 0.32 1.93e-9 Celiac disease or Rheumatoid arthritis; LUSC trans rs4332037 0.539 rs11764590 chr7:2032803 C/T cg11693508 chr17:37793320 STARD3 0.6 7.17 0.37 4.77e-12 Bipolar disorder; LUSC cis rs9527 0.615 rs7089065 chr10:104723022 C/T cg08330031 chr10:104623503 C10orf32 0.31 5.64 0.3 3.54e-8 Arsenic metabolism; LUSC cis rs7904368 0.806 rs45495501 chr10:16861476 G/A cg14835575 chr10:16859367 RSU1 0.78 9.82 0.47 3.58e-20 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC trans rs61931739 0.500 rs7298322 chr12:34445489 A/T cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.32e-18 Morning vs. evening chronotype; LUSC trans rs4332037 0.539 rs56016347 chr7:2060126 C/T cg10840412 chr1:235813424 GNG4 0.57 7.34 0.37 1.61e-12 Bipolar disorder; LUSC cis rs34375054 0.573 rs12581367 chr12:125654641 T/C cg25124228 chr12:125621409 AACS -0.53 -6.97 -0.36 1.7e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 12.96 0.58 2.12e-31 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs2019216 0.500 rs4325621 chr17:21926257 T/G cg22648282 chr17:21454238 C17orf51 -0.53 -7.87 -0.4 5.11e-14 Pelvic organ prolapse; LUSC cis rs1864400 0.690 rs7098237 chr10:43740513 T/A cg15436174 chr10:43711423 RASGEF1A 0.43 6.94 0.36 2.02e-11 Hirschsprung disease; LUSC cis rs977987 0.843 rs2059256 chr16:75395835 G/T cg04384234 chr16:75411784 CFDP1 -0.45 -7.53 -0.38 4.67e-13 Dupuytren's disease; LUSC cis rs7707921 1.000 rs891159 chr5:81491087 A/G cg15871215 chr5:81402204 ATG10 -0.45 -6.7 -0.34 8.63e-11 Breast cancer; LUSC cis rs11264799 0.539 rs11264775 chr1:157578884 A/G cg18268488 chr1:157545234 FCRL4 0.37 6.94 0.36 2.03e-11 IgA nephropathy; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg13395646 chr4:1353034 KIAA1530 -0.62 -9.81 -0.47 3.86e-20 Obesity-related traits; LUSC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.56 -0.38 3.9e-13 Bipolar disorder; LUSC trans rs1005277 0.589 rs2749624 chr10:38529865 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.43 -0.46 7.21e-19 Extrinsic epigenetic age acceleration; LUSC trans rs4295623 0.504 rs11250160 chr8:11592717 G/A cg15556689 chr8:8085844 FLJ10661 -0.52 -7.85 -0.39 5.83e-14 Morning vs. evening chronotype; LUSC cis rs7759001 0.817 rs6913122 chr6:27355292 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg20476274 chr7:133979776 SLC35B4 0.85 16.26 0.66 3.22e-44 Mean platelet volume; LUSC cis rs9733 0.650 rs9803935 chr1:150552622 T/G cg04414720 chr1:150670196 GOLPH3L -0.41 -6.27 -0.32 1.14e-9 Tonsillectomy; LUSC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg09877947 chr5:131593287 PDLIM4 0.42 6.91 0.35 2.42e-11 Blood metabolite levels; LUSC cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg05294307 chr14:35346193 BAZ1A -0.63 -7.66 -0.39 2.06e-13 Psoriasis; LUSC cis rs8014204 0.836 rs12888998 chr14:75292662 G/T cg06637938 chr14:75390232 RPS6KL1 0.65 11.0 0.52 3.23e-24 Caffeine consumption; LUSC trans rs7581030 0.517 rs6731420 chr2:71533300 T/C cg06465196 chr4:154387603 KIAA0922 0.42 6.05 0.31 3.81e-9 Testicular germ cell tumor; LUSC cis rs12410462 1.000 rs12410243 chr1:227669474 A/G cg04117972 chr1:227635322 NA 0.58 7.01 0.36 1.36e-11 Major depressive disorder; LUSC cis rs1003719 0.715 rs2252893 chr21:38507572 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs9650315 0.586 rs67705717 chr8:57208798 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.64 7.8 0.39 7.83e-14 Height; LUSC cis rs1691799 0.899 rs1168317 chr12:66746225 C/T cg16791601 chr12:66731901 HELB -0.71 -12.51 -0.56 1.04e-29 White blood cell count (basophil); LUSC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg13010344 chr12:123464640 ARL6IP4 0.42 5.68 0.3 3e-8 Neutrophil percentage of white cells; LUSC cis rs11098499 0.865 rs4001305 chr4:120359236 G/T cg24375607 chr4:120327624 NA 0.77 11.46 0.53 7.45e-26 Corneal astigmatism; LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg05025164 chr4:1340916 KIAA1530 -0.49 -7.52 -0.38 5.06e-13 Obesity-related traits; LUSC cis rs10744422 0.748 rs2292138 chr12:123339712 A/G cg25930673 chr12:123319894 HIP1R -0.72 -7.12 -0.36 6.69e-12 Schizophrenia; LUSC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.44 6.47 0.33 3.58e-10 Schizophrenia; LUSC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2456568 0.548 rs10765647 chr11:93662459 T/C cg26875233 chr11:93583750 C11orf90 -0.31 -6.04 -0.31 4.07e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs4077468 1.000 rs9662221 chr1:205915745 G/T cg11965913 chr1:205819406 PM20D1 -0.43 -6.41 -0.33 4.91e-10 Cystic fibrosis-related diabetes; LUSC cis rs17270561 0.636 rs77343532 chr6:25828828 G/A cg17691542 chr6:26056736 HIST1H1C 0.49 6.95 0.36 1.88e-11 Iron status biomarkers; LUSC cis rs4499344 0.664 rs4286210 chr19:33101221 T/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg26314531 chr2:26401878 FAM59B -0.7 -9.84 -0.47 3.09e-20 Gut microbiome composition (summer); LUSC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg08472276 chr7:1133186 C7orf50;GPER 0.36 6.12 0.32 2.58e-9 Longevity;Endometriosis; LUSC cis rs6867032 1.000 rs28392808 chr5:2013477 A/G cg26168224 chr5:2018326 NA 0.81 15.07 0.64 1.65e-39 Gut microbiome composition (winter); LUSC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg23283495 chr1:209979779 IRF6 0.64 7.9 0.4 4.12e-14 Cleft lip with or without cleft palate; LUSC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg02564969 chr6:151773285 C6orf211;RMND1 0.46 6.74 0.35 6.91e-11 Menarche (age at onset); LUSC cis rs13631 0.965 rs9411307 chr9:139994947 C/T cg14289826 chr9:140003911 NA 0.37 7.71 0.39 1.46e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs4727027 0.782 rs10245343 chr7:148796333 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.59 7.65 0.39 2.17e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs7937682 0.889 rs484013 chr11:111495779 G/A cg18187862 chr3:45730750 SACM1L 0.53 7.05 0.36 1.06e-11 Primary sclerosing cholangitis; LUSC cis rs709400 0.628 rs3783394 chr14:103858673 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.99 -0.31 5.41e-9 Body mass index; LUSC trans rs1941687 0.527 rs12608181 chr18:31339351 T/G cg27147174 chr7:100797783 AP1S1 -0.54 -8.53 -0.42 5.32e-16 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg09365446 chr1:150670422 GOLPH3L 0.51 7.93 0.4 3.36e-14 Tonsillectomy; LUSC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg22535103 chr8:58192502 C8orf71 -0.68 -7.55 -0.38 4.11e-13 Developmental language disorder (linguistic errors); LUSC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg15212455 chr7:39170539 POU6F2 0.65 11.02 0.52 2.71e-24 IgG glycosylation; LUSC cis rs9487051 0.768 rs399561 chr6:109524979 G/A cg01475377 chr6:109611718 NA -0.35 -5.9 -0.31 9.15e-9 Reticulocyte fraction of red cells; LUSC cis rs1962073 0.528 rs9329223 chr8:10331754 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.78 -0.3 1.69e-8 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); LUSC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.84 -0.3 1.23e-8 Total body bone mineral density; LUSC cis rs12681288 0.676 rs935819 chr8:1021814 T/C cg15309053 chr8:964076 NA 0.31 6.18 0.32 1.82e-9 Schizophrenia; LUSC cis rs1451375 1.000 rs6949897 chr7:50621920 C/T cg18232548 chr7:50535776 DDC 0.51 7.83 0.39 6.32e-14 Malaria; LUSC trans rs61931739 0.500 rs11053208 chr12:34460029 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.27e-17 Morning vs. evening chronotype; LUSC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.13e-16 Schizophrenia; LUSC trans rs8002861 0.870 rs9525855 chr13:44431660 A/G cg12856521 chr11:46389249 DGKZ 0.41 6.52 0.34 2.54e-10 Leprosy; LUSC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg23711669 chr6:146136114 FBXO30 0.7 10.72 0.51 3.12e-23 Lobe attachment (rater-scored or self-reported); LUSC trans rs6951245 0.554 rs11761322 chr7:1151657 A/G cg13565492 chr6:43139072 SRF -0.72 -10.87 -0.51 8.9e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10871290 0.650 rs3760055 chr16:74490529 G/A cg01733217 chr16:74700730 RFWD3 0.7 10.52 0.5 1.58e-22 Breast cancer; LUSC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 11.22 0.52 5.28e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs11098499 0.954 rs10031665 chr4:120422852 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.59 0.34 1.68e-10 Corneal astigmatism; LUSC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg20887711 chr4:1340912 KIAA1530 0.69 11.37 0.53 1.55e-25 Longevity; LUSC cis rs4776059 0.798 rs4390542 chr15:52937960 T/C cg22715398 chr15:52968154 KIAA1370 -0.58 -7.27 -0.37 2.52e-12 Schizophrenia; LUSC cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg05347473 chr6:146136440 FBXO30 0.4 6.78 0.35 5.5e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs950169 0.649 rs12905952 chr15:84691261 G/A cg17507749 chr15:85114479 UBE2QP1 0.56 6.39 0.33 5.58e-10 Schizophrenia; LUSC cis rs9650315 0.733 rs13260778 chr8:57204375 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs921968 0.510 rs591573 chr2:219478193 C/T cg02176678 chr2:219576539 TTLL4 0.7 13.39 0.59 4.88e-33 Mean corpuscular hemoglobin concentration; LUSC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs11105298 0.891 rs3825330 chr12:89933710 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.32 -0.37 1.85e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg22535103 chr8:58192502 C8orf71 -0.58 -6.88 -0.35 2.89e-11 Developmental language disorder (linguistic errors); LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg10802521 chr3:52805072 NEK4 -0.56 -8.85 -0.44 5.15e-17 Bipolar disorder; LUSC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg05340658 chr4:99064831 C4orf37 0.66 11.35 0.53 1.82e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2280018 0.609 rs2941253 chr16:15173746 G/A cg27102117 chr16:15229624 NA 0.56 9.24 0.45 2.99e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs11190604 0.943 rs3750631 chr10:102279294 A/G cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9837602 1.000 rs28714363 chr3:99752068 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.18 0.32 1.82e-9 Breast cancer; LUSC trans rs1941687 0.563 rs7238931 chr18:31334993 G/A cg13755796 chr4:20253514 NA -0.39 -6.01 -0.31 4.87e-9 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs72781680 1.000 rs72781649 chr2:24210864 A/G cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs6831352 0.879 rs56222233 chr4:100069627 T/G cg12011299 chr4:100065546 ADH4 -0.72 -10.42 -0.5 3.38e-22 Alcohol dependence; LUSC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10177180 chr13:96329362 DNAJC3 -0.46 -6.29 -0.33 1e-9 Hepatitis; LUSC cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg17366294 chr4:99064904 C4orf37 0.59 10.48 0.5 2.01e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg12257692 chr3:49977190 RBM6 -0.24 -6.6 -0.34 1.6e-10 Body mass index; LUSC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg10130564 chr11:117069849 TAGLN 0.35 5.98 0.31 5.65e-9 Blood protein levels; LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg13560548 chr3:10150139 C3orf24 0.53 7.43 0.38 9.1e-13 Alzheimer's disease; LUSC cis rs13064411 0.696 rs6808394 chr3:113122524 T/G cg18753928 chr3:113234510 CCDC52 -0.49 -7.49 -0.38 6.23e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs9837602 1.000 rs923471 chr3:99757853 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.37 0.33 6.38e-10 Breast cancer; LUSC cis rs7771547 0.573 rs7744363 chr6:36424665 A/C cg07856975 chr6:36356162 ETV7 -0.36 -6.32 -0.33 8.61e-10 Platelet distribution width; LUSC cis rs60733400 0.500 rs72644697 chr1:2533605 G/A cg18854424 chr1:2615690 NA 0.5 10.1 0.48 4.29e-21 Multiple sclerosis; LUSC cis rs9534288 0.699 rs9567621 chr13:46665814 A/G cg15192986 chr13:46630673 CPB2 -0.67 -9.89 -0.48 2.05e-20 Blood protein levels; LUSC cis rs12620999 0.941 rs4408676 chr2:238085280 C/T cg23555395 chr2:238036564 NA -0.47 -8.19 -0.41 5.77e-15 Systemic lupus erythematosus; LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.79 -0.3 1.64e-8 Platelet count; LUSC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg21782813 chr7:2030301 MAD1L1 0.48 7.89 0.4 4.4e-14 Bipolar disorder and schizophrenia; LUSC cis rs11711311 1.000 rs3732793 chr3:113442198 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.13 0.36 6.16e-12 IgG glycosylation; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg20887711 chr4:1340912 KIAA1530 -0.48 -7.25 -0.37 2.88e-12 Obesity-related traits; LUSC cis rs7772486 0.875 rs7739418 chr6:146359188 G/A cg05347473 chr6:146136440 FBXO30 0.51 8.55 0.42 4.43e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs10761482 0.861 rs10761487 chr10:62104309 C/T cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg24531977 chr5:56204891 C5orf35 0.67 9.31 0.45 1.73e-18 Coronary artery disease; LUSC cis rs1448094 0.967 rs10863109 chr12:86328415 A/G cg02569458 chr12:86230093 RASSF9 0.42 6.81 0.35 4.67e-11 Major depressive disorder; LUSC cis rs34779708 0.966 rs12761675 chr10:35438337 C/T cg03585969 chr10:35415529 CREM -0.59 -8.76 -0.43 9.74e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs12701220 0.803 rs12701432 chr7:1052453 C/T cg20821713 chr7:1055600 C7orf50 -0.57 -7.53 -0.38 4.85e-13 Bronchopulmonary dysplasia; LUSC cis rs208520 0.661 rs7747492 chr6:66857788 A/T cg07460842 chr6:66804631 NA -1.13 -17.72 -0.7 5.26e-50 Exhaled nitric oxide output; LUSC cis rs9303401 0.555 rs8073699 chr17:57236317 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.48 7.16 0.36 5.06e-12 Cognitive test performance; LUSC cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg14458575 chr2:238380390 NA -0.7 -12.34 -0.56 4.49e-29 Prostate cancer; LUSC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.11 -0.41 9.41e-15 Lung cancer; LUSC trans rs9841829 0.807 rs9309980 chr3:85505874 A/G cg20344388 chr21:46829943 COL18A1 -0.29 -6.0 -0.31 5.17e-9 Alcohol consumption; LUSC cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.67 0.65 7.43e-42 Bladder cancer; LUSC cis rs1007190 0.764 rs8082522 chr17:42876340 G/C cg15406952 chr17:42872593 NA -0.59 -6.13 -0.32 2.45e-9 DNA methylation (variation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23926253 chr19:19303735 LOC729991-MEF2B;LOC729991;RFXANK -0.43 -6.39 -0.33 5.51e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21284370 chr13:42621865 DGKH 0.5 7.7 0.39 1.52e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs61931739 0.534 rs1912773 chr12:34097401 T/C cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs1572072 0.762 rs56917105 chr13:24132142 A/T cg24350296 chr13:24144486 TNFRSF19 -0.31 -5.88 -0.31 9.76e-9 Nasopharyngeal carcinoma; LUSC cis rs6845621 0.727 rs4697195 chr4:18900688 C/T cg12196642 chr4:18937545 NA -0.33 -6.24 -0.32 1.32e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs6089829 0.925 rs6122087 chr20:61664553 T/C cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.69 0.34 9.68e-11 Lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25307593 chr12:40499811 SLC2A13 -0.46 -7.06 -0.36 9.62e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg19318889 chr4:1322082 MAEA -0.71 -12.08 -0.55 4.11e-28 Obesity-related traits; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg12432903 chr7:1882776 MAD1L1 -0.4 -6.4 -0.33 5.21e-10 Bipolar disorder and schizophrenia; LUSC trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg25482853 chr8:67687455 SGK3 1.2 17.05 0.68 2.38e-47 Lung disease severity in cystic fibrosis; LUSC trans rs10511400 0.618 rs7637828 chr3:119907510 A/G cg02809009 chr19:50354510 PTOV1 -0.74 -6.32 -0.33 8.57e-10 Economic and political preferences (feminism/equality); LUSC cis rs8017423 0.967 rs11628881 chr14:90713833 C/T cg04374321 chr14:90722782 PSMC1 0.76 12.0 0.55 7.68e-28 Mortality in heart failure; LUSC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg17366294 chr4:99064904 C4orf37 0.6 10.61 0.5 7.52e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.44 0.53 8.42e-26 Menopause (age at onset); LUSC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs907683 0.584 rs2854903 chr2:220288979 C/T cg15015639 chr2:220282977 DES -0.31 -7.16 -0.36 5.22e-12 Resting heart rate; LUSC cis rs10207060 0.500 rs28640956 chr2:240714001 G/C cg07506560 chr2:240697449 NA 0.44 6.9 0.35 2.67e-11 Obesity-related traits; LUSC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg06008330 chr7:65541103 ASL -0.4 -6.37 -0.33 6.38e-10 Aortic root size; LUSC cis rs5758659 0.700 rs739294 chr22:42381726 T/C cg15557168 chr22:42548783 NA -0.4 -6.78 -0.35 5.32e-11 Cognitive function; LUSC cis rs11190604 1.000 rs4919471 chr10:102299239 A/G cg23241863 chr10:102295624 HIF1AN 0.48 5.98 0.31 5.7e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7799006 0.755 rs2256545 chr7:2291943 G/A cg12823233 chr7:2316876 SNX8 -0.47 -8.07 -0.4 1.27e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg11266682 chr4:10021025 SLC2A9 0.58 10.63 0.5 6.51e-23 Bone mineral density; LUSC cis rs12208915 0.708 rs9361481 chr6:79726750 T/A cg05283184 chr6:79620031 NA 0.48 7.42 0.38 9.76e-13 Left atrial antero-posterior diameter; LUSC cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg23173402 chr1:227635558 NA 0.61 7.44 0.38 8.82e-13 Major depressive disorder; LUSC cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg16586182 chr3:47516702 SCAP -0.5 -7.85 -0.39 5.69e-14 Colorectal cancer; LUSC trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs897984 0.683 rs9932572 chr16:30841642 A/G cg00531865 chr16:30841666 NA -0.34 -6.11 -0.32 2.81e-9 Dementia with Lewy bodies; LUSC cis rs1775715 0.737 rs2799000 chr10:32124894 C/T cg04359828 chr10:32216031 ARHGAP12 0.39 6.75 0.35 6.68e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4792901 0.759 rs9907813 chr17:41602858 T/G cg22562494 chr17:41607896 ETV4 -0.32 -6.1 -0.32 2.92e-9 Dupuytren's disease; LUSC cis rs7524258 0.868 rs1304711 chr1:7270320 G/T cg07173049 chr1:7289937 CAMTA1 -0.32 -6.69 -0.34 9.16e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12368653 0.641 rs11172300 chr12:58076515 C/T cg15848620 chr12:58087721 OS9 -0.4 -5.68 -0.3 2.95e-8 Multiple sclerosis; LUSC cis rs1941023 0.584 rs2233253 chr11:60157166 C/T cg08716584 chr11:60157161 MS4A7 -0.65 -12.23 -0.56 1.11e-28 Congenital heart disease (maternal effect); LUSC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg21918786 chr6:109611834 NA -0.36 -6.05 -0.31 3.93e-9 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; LUSC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg00684032 chr4:1343700 KIAA1530 -0.34 -6.11 -0.32 2.83e-9 Obesity-related traits; LUSC cis rs61612642 0.590 rs6931028 chr6:42193064 A/T cg10382835 chr6:42185730 MRPS10 0.65 6.44 0.33 4.12e-10 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs1949733 0.656 rs6845969 chr4:8402465 A/T cg13073564 chr4:8508604 NA -0.41 -8.16 -0.41 6.75e-15 Response to antineoplastic agents; LUSC cis rs9479482 1.000 rs9479403 chr6:150337746 C/T cg25797454 chr6:150327115 RAET1K -0.37 -8.59 -0.43 3.48e-16 Alopecia areata; LUSC cis rs4903604 0.581 rs4899658 chr14:78035392 A/T cg18872420 chr14:78023429 SPTLC2 -0.37 -5.71 -0.3 2.49e-8 Gut microbiome composition (winter); LUSC cis rs9549260 0.564 rs9549270 chr13:41284193 G/T cg21288729 chr13:41239152 FOXO1 0.55 8.45 0.42 9.22e-16 Red blood cell count; LUSC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg11062466 chr8:58055876 NA 0.58 7.3 0.37 2.12e-12 Developmental language disorder (linguistic errors); LUSC cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg08999081 chr20:33150536 PIGU 0.37 6.78 0.35 5.42e-11 Height; LUSC cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg05340658 chr4:99064831 C4orf37 -0.63 -10.62 -0.5 6.66e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs477692 1.000 rs567700 chr10:131423126 C/T cg26102564 chr10:131424627 MGMT 0.39 6.16 0.32 2.05e-9 Response to temozolomide; LUSC cis rs34734847 0.787 rs1814851 chr12:121128633 C/G cg21892295 chr12:121157589 UNC119B -0.36 -6.3 -0.33 9.23e-10 Mean corpuscular volume; LUSC cis rs7917772 0.582 rs10883738 chr10:104321721 T/C cg05855489 chr10:104503620 C10orf26 -0.49 -7.5 -0.38 5.96e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg23711669 chr6:146136114 FBXO30 0.75 13.26 0.59 1.61e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg11764359 chr7:65958608 NA 0.8 13.27 0.59 1.43e-32 Aortic root size; LUSC cis rs9341808 0.718 rs12203867 chr6:80820833 G/T cg08355045 chr6:80787529 NA 0.56 9.85 0.47 2.85e-20 Sitting height ratio; LUSC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.63 0.5 6.32e-23 Schizophrenia; LUSC cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Bladder cancer; LUSC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11890956 chr21:40555474 PSMG1 -0.9 -16.5 -0.67 3.6e-45 Cognitive function; LUSC cis rs9653442 0.510 rs13415583 chr2:100764087 T/G cg07810366 chr2:100720526 AFF3 -0.45 -7.76 -0.39 1.05e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.81 0.3 1.44e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9388451 0.903 rs7758115 chr6:126061502 C/T cg05901451 chr6:126070800 HEY2 -0.93 -18.42 -0.71 9.11e-53 Brugada syndrome; LUSC cis rs9398803 0.830 rs1490387 chr6:126834083 C/A cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.97e-9 Male-pattern baldness; LUSC cis rs7678296 0.649 rs73128366 chr4:37241908 T/C cg06805348 chr4:37245195 KIAA1239 0.58 5.93 0.31 7.47e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg02951883 chr7:2050386 MAD1L1 -0.45 -7.66 -0.39 2.07e-13 Bipolar disorder and schizophrenia; LUSC cis rs11122272 0.735 rs2790876 chr1:231536033 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.99 -0.48 1.01e-20 Hemoglobin concentration; LUSC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg06671706 chr8:8559999 CLDN23 0.47 6.46 0.33 3.77e-10 Obesity-related traits; LUSC cis rs7927592 0.913 rs11228293 chr11:68384646 T/C cg20283391 chr11:68216788 NA -0.6 -8.37 -0.42 1.6e-15 Total body bone mineral density; LUSC cis rs9952991 0.941 rs9952749 chr18:12780456 A/G cg23598886 chr18:12777645 NA 0.65 6.47 0.33 3.49e-10 Inflammatory skin disease; LUSC cis rs240764 0.658 rs11155618 chr6:101181811 C/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.32 -0.33 8.54e-10 Neuroticism; LUSC cis rs13315871 1.000 rs11708590 chr3:58336635 A/G cg12435725 chr3:58293450 RPP14 0.68 7.38 0.37 1.26e-12 Cholesterol, total; LUSC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg03213289 chr20:61660250 NA 0.67 13.65 0.6 5.25e-34 Prostate cancer (SNP x SNP interaction); LUSC cis rs54211 1.000 rs137611 chr22:39697855 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.59 5.82 0.3 1.39e-8 Sudden cardiac arrest; LUSC cis rs4285028 0.699 rs4676758 chr3:121583415 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.79 10.79 0.51 1.74e-23 Multiple sclerosis; LUSC trans rs8002861 0.641 rs6561148 chr13:44426269 C/T cg12856521 chr11:46389249 DGKZ 0.45 6.59 0.34 1.74e-10 Leprosy; LUSC cis rs9653442 0.522 rs4851274 chr2:100870862 T/C cg07810366 chr2:100720526 AFF3 -0.38 -6.21 -0.32 1.56e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7188861 0.768 rs412861 chr16:11382756 T/G cg00044050 chr16:11439710 C16orf75 0.57 6.25 0.32 1.24e-9 HDL cholesterol; LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.25e-9 Menopause (age at onset); LUSC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg06238570 chr21:40685208 BRWD1 -0.63 -10.59 -0.5 8.77e-23 Cognitive function; LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg22875332 chr1:76189707 ACADM 0.84 13.3 0.59 1.14e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg13072238 chr3:49761600 GMPPB -0.7 -8.84 -0.44 5.75e-17 Menarche (age at onset); LUSC cis rs9549260 0.739 rs7330614 chr13:41199421 G/A cg21288729 chr13:41239152 FOXO1 0.6 9.21 0.45 3.75e-18 Red blood cell count; LUSC cis rs2204008 0.540 rs1283306 chr12:38153778 C/A cg13010199 chr12:38710504 ALG10B -0.51 -7.71 -0.39 1.44e-13 Bladder cancer; LUSC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg24881330 chr22:46731750 TRMU 0.89 6.82 0.35 4.27e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs9283706 0.655 rs4016246 chr5:66310192 A/G cg11590213 chr5:66331682 MAST4 0.45 6.93 0.35 2.21e-11 Coronary artery disease; LUSC cis rs11992162 0.636 rs4841642 chr8:11798334 C/T cg21775007 chr8:11205619 TDH 0.44 5.96 0.31 6.52e-9 Monocyte count; LUSC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg07936489 chr17:37558343 FBXL20 0.71 9.88 0.48 2.23e-20 Glomerular filtration rate (creatinine); LUSC cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg24642439 chr20:33292090 TP53INP2 -0.49 -7.55 -0.38 4.18e-13 Glomerular filtration rate (creatinine); LUSC trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs34734847 0.703 rs7978125 chr12:121167039 A/G cg27246729 chr12:121163418 ACADS 0.41 6.5 0.34 2.86e-10 Mean corpuscular volume; LUSC cis rs7124681 0.585 rs10838773 chr11:47834346 G/A cg20307385 chr11:47447363 PSMC3 0.43 6.08 0.32 3.24e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs1801251 1.000 rs4517962 chr2:233578337 T/C cg25237894 chr2:233734115 C2orf82 0.34 6.39 0.33 5.47e-10 Coronary artery disease; LUSC trans rs1994135 0.647 rs67243558 chr12:33695383 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.39 0.46 9.49e-19 Resting heart rate; LUSC cis rs9443189 0.570 rs6931578 chr6:76272310 C/T cg01950844 chr6:76311363 SENP6 0.69 7.11 0.36 7.26e-12 Prostate cancer; LUSC cis rs6500395 1.000 rs1362636 chr16:48712779 T/C cg04672837 chr16:48644449 N4BP1 -0.47 -7.06 -0.36 9.68e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9462027 0.628 rs2814957 chr6:34702689 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.31 -5.65 -0.3 3.46e-8 Systemic lupus erythematosus; LUSC cis rs739401 0.595 rs402806 chr11:3066432 A/G cg08508325 chr11:3079039 CARS -0.55 -13.94 -0.61 4.05e-35 Longevity; LUSC cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg05868516 chr6:26286170 HIST1H4H 0.36 5.77 0.3 1.79e-8 Educational attainment; LUSC cis rs1577917 0.727 rs9351065 chr6:86360428 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.78 -0.43 8.73e-17 Response to antipsychotic treatment; LUSC cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg06064525 chr11:970664 AP2A2 -0.49 -10.84 -0.51 1.15e-23 Alzheimer's disease (late onset); LUSC cis rs7712401 0.645 rs154497 chr5:122221420 T/C cg19077854 chr5:122220652 SNX24 0.4 9.02 0.44 1.46e-17 Mean platelet volume; LUSC cis rs17270561 0.609 rs9393662 chr6:25739670 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC trans rs225245 0.791 rs2285742 chr17:34018682 C/T cg19694781 chr19:47549865 TMEM160 -0.39 -6.06 -0.31 3.61e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15506890 chr2:3487001 NA -0.58 -9.58 -0.46 2.23e-19 Neurofibrillary tangles; LUSC cis rs12541635 0.934 rs7008840 chr8:107016404 T/C cg10147462 chr8:107024639 NA 0.55 9.6 0.47 1.96e-19 Age of smoking initiation; LUSC cis rs367615 0.704 rs72802966 chr5:108846754 T/G cg17395555 chr5:108820864 NA 0.6 11.27 0.52 3.59e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg09365446 chr1:150670422 GOLPH3L 0.49 7.26 0.37 2.73e-12 Melanoma; LUSC cis rs9902453 0.933 rs7216487 chr17:28502642 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.8 0.39 8.05e-14 Coffee consumption (cups per day); LUSC cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.56 -0.34 2.08e-10 Monocyte percentage of white cells; LUSC cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg15556689 chr8:8085844 FLJ10661 0.59 8.57 0.42 3.88e-16 Neuroticism; LUSC cis rs1003719 0.788 rs2835600 chr21:38468958 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.27 0.45 2.29e-18 Prudent dietary pattern; LUSC cis rs1801251 1.000 rs2592113 chr2:233669553 C/T cg08000102 chr2:233561755 GIGYF2 0.72 11.92 0.55 1.5e-27 Coronary artery disease; LUSC cis rs17270561 0.609 rs1937127 chr6:25769872 G/T cg17691542 chr6:26056736 HIST1H1C -0.5 -6.73 -0.35 7.49e-11 Iron status biomarkers; LUSC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg12863693 chr15:85201151 NMB 0.34 6.76 0.35 6.19e-11 Schizophrenia; LUSC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.72 0.47 7.61e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.59 0.38 3.26e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9329221 0.527 rs4841351 chr8:10327367 G/A cg21775007 chr8:11205619 TDH -0.43 -5.98 -0.31 5.87e-9 Neuroticism; LUSC cis rs76878669 0.561 rs56321771 chr11:66161072 C/T cg18002602 chr11:66138449 SLC29A2 0.45 7.98 0.4 2.43e-14 Educational attainment (years of education); LUSC cis rs1808579 0.935 rs1623060 chr18:21143183 C/T cg14672496 chr18:21087552 C18orf8 0.38 6.75 0.35 6.4e-11 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs6582630 0.539 rs35114325 chr12:38320886 G/T cg13010199 chr12:38710504 ALG10B -0.43 -6.51 -0.34 2.82e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs9807989 0.507 rs10203558 chr2:103027640 T/C cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.69e-12 Asthma; LUSC cis rs11098499 0.955 rs1511019 chr4:120166007 T/G cg09307838 chr4:120376055 NA 0.73 10.42 0.5 3.49e-22 Corneal astigmatism; LUSC cis rs4253772 0.872 rs78864133 chr22:46638486 C/T cg18190219 chr22:46762943 CELSR1 -0.47 -5.66 -0.3 3.23e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9300255 0.679 rs12817892 chr12:123728702 G/A cg00376283 chr12:123451042 ABCB9 -0.69 -7.76 -0.39 1.05e-13 Neutrophil percentage of white cells; LUSC cis rs72781680 0.898 rs72788218 chr2:24090435 C/T cg20701182 chr2:24300061 SF3B14 0.53 5.87 0.31 1.05e-8 Lymphocyte counts; LUSC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs4332037 0.539 rs62444881 chr7:2052318 C/T cg25206134 chr2:45395956 NA 0.63 7.26 0.37 2.74e-12 Bipolar disorder; LUSC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg04539111 chr16:67997858 SLC12A4 0.49 6.12 0.32 2.59e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg07092213 chr7:1199455 ZFAND2A -0.53 -8.27 -0.41 3.21e-15 Longevity;Endometriosis; LUSC cis rs4805834 0.719 rs55977451 chr19:33298122 A/G cg00891608 chr19:33463040 C19orf40;CCDC123 -0.58 -5.67 -0.3 3.14e-8 Creatinine levels; LUSC trans rs6601327 0.551 rs13272424 chr8:9575319 T/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.27 -0.32 1.11e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg11941060 chr3:133502564 NA 0.51 7.87 0.4 4.92e-14 Iron status biomarkers; LUSC trans rs8000245 0.643 rs9530284 chr13:74718939 C/G cg00896254 chr7:45149652 TBRG4 -0.49 -6.22 -0.32 1.49e-9 Optic nerve measurement (rim area); LUSC cis rs1775715 0.737 rs2808072 chr10:32205504 A/T cg26784012 chr10:32216390 ARHGAP12 0.45 7.49 0.38 6.37e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 8.12 0.41 9.26e-15 Height; LUSC cis rs17253792 0.822 rs80321745 chr14:56162947 T/A cg01858014 chr14:56050164 KTN1 -0.85 -6.82 -0.35 4.29e-11 Putamen volume; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg10339542 chr17:10600919 C17orf48;SCO1 0.37 6.06 0.31 3.59e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg05347473 chr6:146136440 FBXO30 0.46 7.96 0.4 2.72e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs709400 1.000 rs58133129 chr14:104104759 A/G cg12935359 chr14:103987150 CKB -0.39 -5.66 -0.3 3.21e-8 Body mass index; LUSC cis rs9814567 0.793 rs55940445 chr3:134306064 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.9 0.61 5.49e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs56346965 0.967 rs2293765 chr2:191520845 C/A cg11845111 chr2:191398756 TMEM194B 0.41 5.88 0.31 9.8e-9 Bone mineral density (Ward's triangle area); LUSC cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.72 0.43 1.29e-16 Menopause (age at onset); LUSC trans rs1171606 0.731 rs1171645 chr10:61452592 A/T cg14119616 chr11:17099403 RPS13 -0.41 -6.0 -0.31 5.23e-9 Acylcarnitine levels; LUSC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg07414643 chr4:187882934 NA -0.53 -9.82 -0.47 3.67e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7180079 0.686 rs11071801 chr15:64883884 C/T cg08069370 chr15:64387884 SNX1 0.54 5.76 0.3 1.93e-8 Monocyte count; LUSC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg21854759 chr1:92012499 NA -0.53 -8.99 -0.44 1.82e-17 Breast cancer; LUSC cis rs977987 0.806 rs766521 chr16:75424154 A/G cg04384234 chr16:75411784 CFDP1 0.43 7.07 0.36 8.88e-12 Dupuytren's disease; LUSC cis rs9650657 0.504 rs10108347 chr8:11033517 G/C cg27411982 chr8:10470053 RP1L1 -0.4 -6.25 -0.32 1.24e-9 Neuroticism; LUSC cis rs2573652 0.723 rs4577068 chr15:100515959 T/A cg09918751 chr15:100517450 ADAMTS17 -0.52 -9.66 -0.47 1.28e-19 Height; LUSC cis rs4891159 0.548 rs11150952 chr18:74128188 T/C cg24786174 chr18:74118243 ZNF516 0.97 21.48 0.76 6.55e-65 Longevity; LUSC cis rs4969178 0.965 rs8071889 chr17:76398101 A/G cg20026190 chr17:76395443 PGS1 0.45 8.07 0.4 1.29e-14 HDL cholesterol levels; LUSC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11890956 chr21:40555474 PSMG1 1.0 18.59 0.71 1.79e-53 Cognitive function; LUSC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Melanoma; LUSC cis rs829880 0.858 rs733180 chr12:98842588 C/T cg25150519 chr12:98850993 NA 0.69 10.87 0.51 9.24e-24 Colonoscopy-negative controls vs population controls; LUSC trans rs4332037 0.851 rs1403175 chr7:1964357 A/T cg11693508 chr17:37793320 STARD3 -0.65 -7.91 -0.4 3.87e-14 Bipolar disorder; LUSC cis rs11098499 0.644 rs3806808 chr4:120551085 A/C cg09307838 chr4:120376055 NA 0.65 9.8 0.47 4.22e-20 Corneal astigmatism; LUSC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Melanoma; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg04633298 chr17:71229235 FAM104A;C17orf80 0.51 6.18 0.32 1.89e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg05855489 chr10:104503620 C10orf26 0.59 9.39 0.46 9.82e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg14844989 chr11:31128820 NA -0.39 -6.0 -0.31 5.2e-9 Red blood cell count; LUSC cis rs2303282 0.716 rs2550308 chr16:56416228 C/G cg00500540 chr16:56394104 NA -0.44 -7.57 -0.38 3.6e-13 Breast cancer; LUSC cis rs9549367 0.789 rs3794422 chr13:113893729 G/A cg00898013 chr13:113819073 PROZ -0.57 -8.04 -0.4 1.55e-14 Platelet distribution width; LUSC cis rs1882538 0.503 rs1345938 chr7:133137867 C/T cg10665199 chr7:133106180 EXOC4 -0.59 -8.07 -0.4 1.3e-14 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs2258769 chr20:25276680 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.51 0.75 4.37e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg09165964 chr15:75287851 SCAMP5 -1.06 -16.07 -0.66 1.91e-43 Blood trace element (Zn levels); LUSC cis rs7582720 1.000 rs72936870 chr2:203789679 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg22467129 chr15:76604101 ETFA -0.45 -6.99 -0.36 1.51e-11 Blood metabolite levels; LUSC cis rs4423214 1.000 rs2276362 chr11:71174452 A/G cg05163923 chr11:71159392 DHCR7 0.74 11.12 0.52 1.22e-24 Vitamin D levels; LUSC cis rs4604732 0.631 rs11490199 chr1:247625737 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs10992471 0.603 rs12342019 chr9:95192508 C/T cg14631576 chr9:95140430 CENPP -0.35 -6.48 -0.33 3.26e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs34779708 0.966 rs11010135 chr10:35518063 A/G cg03585969 chr10:35415529 CREM 0.61 8.69 0.43 1.64e-16 Inflammatory bowel disease;Crohn's disease; LUSC trans rs273218 0.573 rs16882051 chr5:53342979 T/C cg12559925 chr2:235863365 SH3BP4 0.45 5.95 0.31 6.79e-9 Migraine; LUSC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC trans rs11088226 0.681 rs4547609 chr21:33953542 G/A cg09050820 chr6:167586206 TCP10L2 0.75 9.66 0.47 1.28e-19 Gastritis; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg01238044 chr22:24384105 GSTT1 0.69 11.09 0.52 1.54e-24 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.16 0.41 6.97e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1538970 0.961 rs884962 chr1:45847981 G/A cg06784218 chr1:46089804 CCDC17 0.32 5.76 0.3 1.92e-8 Platelet count; LUSC cis rs7598759 0.548 rs1584462 chr2:232369798 A/G cg19187155 chr2:232395269 NMUR1 0.92 16.08 0.66 1.8e-43 Noise-induced hearing loss; LUSC cis rs6163 0.588 rs10786706 chr10:104500659 C/T cg05855489 chr10:104503620 C10orf26 0.93 18.71 0.72 6.16e-54 Waist circumference;Hip circumference; LUSC cis rs1107366 0.618 rs1447657 chr3:125929471 A/G cg01346077 chr3:125931526 NA 0.51 9.96 0.48 1.2e-20 Metabolite levels; LUSC cis rs2731664 0.792 rs652242 chr5:176873010 C/G cg23176889 chr5:176863531 GRK6 -0.69 -14.3 -0.62 1.63e-36 Intelligence (multi-trait analysis); LUSC cis rs13191362 0.507 rs1079020 chr6:163066596 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -8.16 -0.41 6.99e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg07936489 chr17:37558343 FBXL20 -0.66 -9.67 -0.47 1.15e-19 Glomerular filtration rate (creatinine); LUSC cis rs1538970 0.962 rs3219472 chr1:45804050 A/G cg05343316 chr1:45956843 TESK2 -0.59 -8.37 -0.42 1.59e-15 Platelet count; LUSC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.53 -0.38 4.63e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs1577917 0.876 rs12201992 chr6:86618219 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.64 -0.34 1.24e-10 Response to antipsychotic treatment; LUSC cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs4974559 0.739 rs28411197 chr4:1279781 C/T cg02980000 chr4:1222292 CTBP1 1.02 9.29 0.45 2.09e-18 Systolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19969113 chr12:118810441 TAOK3 -0.45 -6.0 -0.31 5.14e-9 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.612 rs6830172 chr4:99093947 G/A cg05340658 chr4:99064831 C4orf37 0.58 9.52 0.46 3.6e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg26408565 chr15:76604113 ETFA 0.53 8.77 0.43 9.05e-17 Blood metabolite levels; LUSC cis rs62400317 0.762 rs10484626 chr6:44882271 A/G cg20913747 chr6:44695427 NA -0.47 -7.43 -0.38 9.43e-13 Total body bone mineral density; LUSC cis rs3740713 1.000 rs73440634 chr11:18473546 T/A cg23797887 chr11:18477753 LDHAL6A -0.54 -6.53 -0.34 2.45e-10 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs4786125 0.519 rs1388805 chr16:6929947 C/T cg03623568 chr16:6915990 A2BP1 -0.48 -7.79 -0.39 8.49e-14 Heart rate variability traits (SDNN); LUSC cis rs9644630 0.504 rs62496181 chr8:19318989 A/T cg06562184 chr8:19319451 CSGALNACT1 0.48 8.06 0.4 1.33e-14 Oropharynx cancer; LUSC cis rs4965006 0.915 rs7969545 chr12:132419157 C/T cg00588090 chr12:132412438 PUS1 -0.46 -8.03 -0.4 1.7e-14 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs877282 0.853 rs10904544 chr10:756966 A/G cg17470449 chr10:769945 NA 0.5 6.73 0.35 7.34e-11 Uric acid levels; LUSC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 7.55 0.38 4.2e-13 Reticulocyte count; LUSC cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg23649088 chr2:200775458 C2orf69 0.59 7.35 0.37 1.56e-12 Schizophrenia; LUSC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg04369109 chr6:150039330 LATS1 -0.6 -8.71 -0.43 1.44e-16 Lung cancer; LUSC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg01283332 chr5:1856932 NA -0.34 -6.46 -0.33 3.77e-10 Cardiovascular disease risk factors; LUSC cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg08999081 chr20:33150536 PIGU 0.46 8.24 0.41 3.95e-15 Coronary artery disease; LUSC cis rs7296418 0.630 rs11057238 chr12:123767971 C/A cg05973401 chr12:123451056 ABCB9 0.53 7.68 0.39 1.73e-13 Platelet count; LUSC cis rs13256369 0.950 rs13255655 chr8:8577736 C/T cg17143192 chr8:8559678 CLDN23 0.64 8.71 0.43 1.41e-16 Obesity-related traits; LUSC cis rs4253772 0.530 rs9615933 chr22:46677298 G/A cg00784671 chr22:46762841 CELSR1 -0.53 -6.26 -0.32 1.21e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.83 0.35 3.98e-11 Intelligence (multi-trait analysis); LUSC cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg07741184 chr6:167504864 NA 0.43 7.49 0.38 6.4e-13 Primary biliary cholangitis; LUSC cis rs78472555 0.507 rs2061007 chr15:100269680 C/G cg23669855 chr15:100272142 LYSMD4 0.36 5.74 0.3 2.08e-8 Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.48 8.16 0.41 6.96e-15 Total body bone mineral density; LUSC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg00750074 chr16:89608354 SPG7 -0.45 -7.89 -0.4 4.49e-14 Multiple myeloma (IgH translocation); LUSC cis rs2425143 1.000 rs11699690 chr20:34271774 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -6.37 -0.33 6.32e-10 Blood protein levels; LUSC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg18190219 chr22:46762943 CELSR1 -0.49 -6.08 -0.32 3.25e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs501916 0.634 rs10851459 chr15:48061510 C/A cg16110827 chr15:48056943 SEMA6D -0.4 -6.19 -0.32 1.73e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg03433033 chr1:76189801 ACADM -0.65 -8.64 -0.43 2.29e-16 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6121246 0.909 rs6087778 chr20:30354142 G/A cg18721089 chr20:30220636 NA -0.35 -5.94 -0.31 7.09e-9 Mean corpuscular hemoglobin; LUSC cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg24675056 chr1:15929824 NA 0.4 6.95 0.36 1.96e-11 Systolic blood pressure; LUSC cis rs250677 0.958 rs36068 chr5:148417512 C/T cg23229984 chr5:148520753 ABLIM3 0.37 5.97 0.31 6.15e-9 Breast cancer; LUSC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.16 15.5 0.65 3.26e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg10792982 chr14:105748885 BRF1 0.48 8.55 0.42 4.51e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs11155671 0.530 rs9968871 chr6:150209196 G/A cg13206674 chr6:150067644 NUP43 0.43 6.44 0.33 4.2e-10 Testicular germ cell tumor; LUSC cis rs6845621 0.727 rs7676193 chr4:18889088 C/T cg12196642 chr4:18937545 NA -0.38 -6.74 -0.35 6.91e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs11252926 0.770 rs2124585 chr10:680428 G/A cg18196295 chr10:418757 DIP2C 0.38 5.89 0.31 9.49e-9 Psychosis in Alzheimer's disease; LUSC cis rs1355223 0.752 rs17359064 chr11:34673884 C/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.98 -0.31 5.76e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs909002 0.800 rs7549590 chr1:32109849 G/A cg13919466 chr1:32135498 COL16A1 -0.31 -5.83 -0.3 1.3e-8 Intelligence (multi-trait analysis); LUSC cis rs950027 0.549 rs11636114 chr15:45601412 C/G cg14582100 chr15:45693742 SPATA5L1 0.43 7.61 0.38 2.88e-13 Response to fenofibrate (adiponectin levels); LUSC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.02e-14 Major depressive disorder; LUSC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs3540 0.597 rs4932346 chr15:91048991 T/C cg22089800 chr15:90895588 ZNF774 -0.65 -9.81 -0.47 3.93e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7537052 0.646 rs6680302 chr1:36653540 C/T cg24686825 chr1:36642396 MAP7D1 -0.75 -13.25 -0.59 1.71e-32 Schizophrenia; LUSC cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg08999081 chr20:33150536 PIGU 0.52 10.42 0.5 3.46e-22 Glomerular filtration rate (creatinine); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg01538021 chr17:38296400 CASC3 -0.39 -6.03 -0.31 4.39e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00377757 chr17:76921538 TIMP2 -0.52 -6.7 -0.34 8.81e-11 Bipolar disorder and schizophrenia; LUSC cis rs7605827 0.930 rs7575290 chr2:15597322 C/T cg19274914 chr2:15703543 NA 0.46 8.8 0.43 7.47e-17 Educational attainment (years of education); LUSC cis rs12760731 0.623 rs12045201 chr1:178399218 A/G cg00404053 chr1:178313656 RASAL2 0.49 5.94 0.31 7.13e-9 Obesity-related traits; LUSC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg20503657 chr10:835505 NA 0.97 13.52 0.59 1.62e-33 Eosinophil percentage of granulocytes; LUSC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg27494647 chr7:150038898 RARRES2 0.45 7.08 0.36 8.32e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs6121246 0.609 rs6060983 chr20:30420924 T/C cg13852791 chr20:30311386 BCL2L1 0.86 12.49 0.56 1.18e-29 Mean corpuscular hemoglobin; LUSC cis rs2760061 0.583 rs1774757 chr1:228211135 C/G cg02753203 chr1:228287806 NA 1.0 19.88 0.74 1.44e-58 Diastolic blood pressure; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18923964 chr14:35451807 SRP54 -0.42 -6.15 -0.32 2.26e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg01416388 chr22:39784598 NA -0.44 -7.18 -0.37 4.61e-12 Intelligence (multi-trait analysis); LUSC cis rs10464366 0.746 rs4723822 chr7:39141613 C/T cg18850127 chr7:39170497 POU6F2 0.62 9.39 0.46 9.69e-19 IgG glycosylation; LUSC cis rs4595586 0.525 rs34204378 chr12:39425759 C/T cg26384229 chr12:38710491 ALG10B 0.55 7.71 0.39 1.48e-13 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg21972741 chr5:435613 AHRR 0.36 6.8 0.35 4.8e-11 Cystic fibrosis severity; LUSC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22307029 chr19:49891270 CCDC155 0.61 7.78 0.39 9.21e-14 Multiple sclerosis; LUSC cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg06108461 chr20:60628389 TAF4 -0.93 -15.59 -0.65 1.53e-41 Body mass index; LUSC trans rs3749237 1.000 rs11920900 chr3:49823024 G/C cg21659725 chr3:3221576 CRBN 0.61 8.48 0.42 7.14e-16 Resting heart rate; LUSC trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg15934090 chr1:100435551 SLC35A3 0.48 8.34 0.42 1.92e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs10506458 0.915 rs79133015 chr12:63396838 G/A cg22491629 chr6:157744540 C6orf35 -0.9 -10.83 -0.51 1.29e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg00677455 chr12:58241039 CTDSP2 0.59 8.48 0.42 7.33e-16 Multiple sclerosis; LUSC cis rs1048238 0.506 rs1262788 chr1:16215608 G/C cg21385522 chr1:16154831 NA -0.54 -8.48 -0.42 7.6e-16 Systolic blood pressure; LUSC cis rs3862435 1.000 rs7496379 chr15:91074531 T/C cg22089800 chr15:90895588 ZNF774 -0.59 -5.66 -0.3 3.19e-8 Response to exercise (triglyceride level interaction); LUSC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg24829409 chr8:58192753 C8orf71 -0.64 -7.74 -0.39 1.17e-13 Developmental language disorder (linguistic errors); LUSC trans rs877282 0.898 rs2004478 chr10:770709 C/A cg22713356 chr15:30763199 NA 1.06 15.04 0.64 2.08e-39 Uric acid levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22734315 chr16:81069742 ATMIN -0.57 -6.85 -0.35 3.57e-11 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg05347473 chr6:146136440 FBXO30 -0.48 -8.14 -0.41 8e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg07061783 chr6:25882402 NA 0.43 6.06 0.31 3.6e-9 Blood metabolite levels; LUSC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.52 8.52 0.42 5.56e-16 Parkinson's disease; LUSC cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.69 -8.41 -0.42 1.22e-15 Chronic sinus infection; LUSC cis rs9303401 0.659 rs3809724 chr17:57061238 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.84 12.53 0.57 9.03e-30 Cognitive test performance; LUSC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg12292205 chr6:26970375 C6orf41 -0.54 -9.22 -0.45 3.48e-18 Schizophrenia; LUSC cis rs6681460 0.674 rs2121051 chr1:67017177 G/A cg02459107 chr1:67143332 SGIP1 0.37 6.12 0.32 2.67e-9 Presence of antiphospholipid antibodies; LUSC cis rs7608623 0.773 rs3795942 chr2:23919375 C/T cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.72 8.89 0.44 3.76e-17 Gut microbiome composition (summer); LUSC cis rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05901451 chr6:126070800 HEY2 0.58 8.94 0.44 2.75e-17 Endometrial cancer; LUSC cis rs13191362 0.507 rs2849534 chr6:163144657 T/A cg06582575 chr6:163149167 PACRG;PARK2 -0.63 -9.97 -0.48 1.11e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg06363034 chr20:62225388 GMEB2 -0.47 -7.88 -0.4 4.78e-14 Glioblastoma; LUSC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg23711669 chr6:146136114 FBXO30 0.74 11.89 0.55 1.96e-27 Lobe attachment (rater-scored or self-reported); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg25152348 chr22:50946712 NCAPH2;LMF2 0.37 6.24 0.32 1.35e-9 Calcium levels; LUSC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg12288994 chr5:1860383 NA 0.32 7.06 0.36 9.85e-12 Cardiovascular disease risk factors; LUSC cis rs4363385 0.747 rs4845508 chr1:152968421 G/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 3.97e-14 Inflammatory skin disease; LUSC cis rs7677751 0.848 rs7673625 chr4:55088586 C/T cg17187183 chr4:55093834 PDGFRA 0.38 5.83 0.3 1.3e-8 Corneal astigmatism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01777103 chr8:145550585 DGAT1 0.66 6.25 0.32 1.23e-9 Cognitive performance; LUSC cis rs4356932 0.905 rs6532086 chr4:76937278 G/A cg00809888 chr4:76862425 NAAA 0.35 5.82 0.3 1.34e-8 Blood protein levels; LUSC cis rs6494488 0.500 rs72742909 chr15:64841440 A/G cg08069370 chr15:64387884 SNX1 -0.64 -5.65 -0.3 3.48e-8 Coronary artery disease; LUSC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg06028605 chr16:24865363 SLC5A11 -0.57 -8.33 -0.41 2.16e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg15704280 chr7:45808275 SEPT13 0.99 14.44 0.62 4.72e-37 Coronary artery disease; LUSC cis rs4692589 0.581 rs6817357 chr4:170962516 A/G cg19918862 chr4:170955249 NA 0.36 6.59 0.34 1.73e-10 Anxiety disorder; LUSC cis rs4851251 1.000 rs4851251 chr2:100753490 C/T cg22139774 chr2:100720529 AFF3 0.47 7.02 0.36 1.26e-11 Educational attainment (years of education); LUSC trans rs6952808 0.723 rs11765550 chr7:2027324 G/A cg04565464 chr8:145669602 NFKBIL2 0.39 6.37 0.33 6.11e-10 Bipolar disorder and schizophrenia; LUSC cis rs1185460 0.565 rs657685 chr11:118912982 G/C cg01677386 chr11:118938358 VPS11 0.44 6.34 0.33 7.52e-10 Coronary artery disease; LUSC cis rs12200782 1.000 rs72845509 chr6:26639865 T/C cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg06108461 chr20:60628389 TAF4 -1.01 -16.53 -0.67 2.89e-45 Body mass index; LUSC cis rs6430585 1.000 rs73958618 chr2:136500475 A/G cg07169764 chr2:136633963 MCM6 0.89 12.15 0.55 2.2e-28 Corneal structure; LUSC cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg00012203 chr2:219082015 ARPC2 -0.7 -11.59 -0.54 2.53e-26 Colorectal cancer; LUSC cis rs2997447 0.846 rs3008417 chr1:26403470 G/A cg19633962 chr1:26362018 EXTL1 -0.5 -5.88 -0.31 9.7e-9 QRS complex (12-leadsum); LUSC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg24154853 chr7:158122151 PTPRN2 -0.42 -8.24 -0.41 3.89e-15 Calcium levels; LUSC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg07936489 chr17:37558343 FBXL20 0.71 10.08 0.48 4.93e-21 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg05347473 chr6:146136440 FBXO30 0.57 9.79 0.47 4.77e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs344364 0.511 rs2917515 chr16:1945271 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.71 -8.73 -0.43 1.28e-16 Glomerular filtration rate in chronic kidney disease; LUSC trans rs2204008 0.577 rs2623049 chr12:38018831 G/A cg06521331 chr12:34319734 NA 0.4 6.42 0.33 4.74e-10 Bladder cancer; LUSC cis rs472402 0.580 rs11738248 chr5:6657494 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.44 -6.45 -0.33 4.03e-10 Response to amphetamines; LUSC cis rs10751667 0.666 rs4074233 chr11:977685 G/A ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.3e-10 Alzheimer's disease (late onset); LUSC cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg04450456 chr4:17643702 FAM184B -0.36 -5.78 -0.3 1.73e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.78 0.43 8.33e-17 Menopause (age at onset); LUSC cis rs9513627 0.915 rs73556177 chr13:100121840 G/A cg25919922 chr13:100150906 NA -0.8 -6.96 -0.36 1.83e-11 Obesity-related traits; LUSC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg11752832 chr7:134001865 SLC35B4 0.6 9.43 0.46 7.36e-19 Mean platelet volume; LUSC cis rs2281558 0.876 rs2274890 chr20:25301022 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.63 9.49 0.46 4.45e-19 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs701145 0.585 rs1727919 chr3:153788757 G/A cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC cis rs854765 0.583 rs7222480 chr17:17818817 G/T cg16928487 chr17:17741425 SREBF1 -0.44 -8.6 -0.43 3.22e-16 Total body bone mineral density; LUSC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg17385448 chr1:15911702 AGMAT 0.35 6.08 0.32 3.25e-9 Systolic blood pressure; LUSC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg04450456 chr4:17643702 FAM184B 0.35 5.8 0.3 1.56e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg21862992 chr11:68658383 NA 0.52 8.06 0.4 1.39e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg17252645 chr8:143867129 LY6D 0.38 6.58 0.34 1.8e-10 Urinary tract infection frequency; LUSC cis rs2637266 0.905 rs2579772 chr10:78406555 A/G cg18941641 chr10:78392320 NA 0.41 7.37 0.37 1.34e-12 Pulmonary function; LUSC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.44 -8.03 -0.4 1.63e-14 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs79349575 0.594 rs62078375 chr17:47034974 A/G cg22482690 chr17:47019901 SNF8 0.38 7.01 0.36 1.35e-11 Type 2 diabetes; LUSC trans rs61931739 0.500 rs10844846 chr12:34394611 C/G cg13010199 chr12:38710504 ALG10B 0.58 9.23 0.45 3.24e-18 Morning vs. evening chronotype; LUSC cis rs9611519 1.000 rs9611520 chr22:41613303 C/T cg13813247 chr22:41461852 NA -0.36 -6.41 -0.33 4.96e-10 Neuroticism; LUSC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg11244672 chr19:19639970 YJEFN3 -0.54 -7.01 -0.36 1.36e-11 Bipolar disorder; LUSC cis rs11122272 0.766 rs2739511 chr1:231526490 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.3 -0.49 8.89e-22 Hemoglobin concentration; LUSC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg25019033 chr10:957182 NA -0.52 -5.79 -0.3 1.62e-8 Eosinophil percentage of granulocytes; LUSC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg11062466 chr8:58055876 NA 0.48 5.96 0.31 6.37e-9 Developmental language disorder (linguistic errors); LUSC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg01475377 chr6:109611718 NA 0.46 8.35 0.42 1.83e-15 Reticulocyte fraction of red cells; LUSC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg05347473 chr6:146136440 FBXO30 0.56 9.49 0.46 4.63e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -7.98 -0.4 2.36e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -10.28 -0.49 9.82e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs554111 0.574 rs4060971 chr1:21506930 C/T cg01072550 chr1:21505969 NA -0.39 -5.88 -0.31 9.87e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs9388451 0.869 rs7764016 chr6:126070789 T/G cg05901451 chr6:126070800 HEY2 -0.96 -18.52 -0.71 3.38e-53 Brugada syndrome; LUSC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg16584290 chr5:462447 EXOC3 -0.34 -5.81 -0.3 1.46e-8 Cystic fibrosis severity; LUSC trans rs656319 0.647 rs13264668 chr8:9884877 C/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.59 -0.34 1.75e-10 Myopia (pathological); LUSC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 11.14 0.52 1.03e-24 Platelet count; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03352830 chr11:487213 PTDSS2 0.78 9.42 0.46 7.77e-19 Body mass index; LUSC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg17968037 chr7:100024898 ZCWPW1 -0.41 -5.9 -0.31 8.89e-9 Platelet count; LUSC trans rs8072100 0.666 rs6503804 chr17:45772447 G/A cg04995722 chr7:26192034 NFE2L3 -0.42 -6.45 -0.33 3.83e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs61931739 0.857 rs419112 chr12:34130528 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.92 0.35 2.3e-11 Morning vs. evening chronotype; LUSC cis rs921968 0.541 rs561570 chr2:219379348 T/A cg02176678 chr2:219576539 TTLL4 0.74 14.4 0.62 6.68e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs1506636 0.927 rs6959270 chr7:123310628 G/A cg03229431 chr7:123269106 ASB15 -0.65 -10.68 -0.5 4.12e-23 Plateletcrit;Platelet count; LUSC cis rs7524258 0.934 rs6689453 chr1:7288384 C/T cg07173049 chr1:7289937 CAMTA1 0.34 7.03 0.36 1.19e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7192750 0.583 rs8046916 chr16:72047751 C/G cg14768367 chr16:72042858 DHODH -0.7 -5.78 -0.3 1.68e-8 LDL cholesterol levels;Total cholesterol levels; LUSC trans rs1908814 0.516 rs60176945 chr8:11796674 T/C cg06636001 chr8:8085503 FLJ10661 0.54 7.98 0.4 2.44e-14 Neuroticism; LUSC cis rs7100689 0.725 rs2185425 chr10:82139941 T/C cg00277334 chr10:82204260 NA -0.48 -6.6 -0.34 1.62e-10 Post bronchodilator FEV1; LUSC cis rs62408225 0.888 rs58453446 chr6:90948093 G/C cg06866423 chr6:90926672 BACH2 0.4 5.68 0.3 2.92e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg01028140 chr2:1542097 TPO -0.6 -7.99 -0.4 2.16e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg05347473 chr6:146136440 FBXO30 0.65 11.19 0.52 6.52e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg12463550 chr7:65579703 CRCP 0.53 7.66 0.39 2.06e-13 Aortic root size; LUSC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg09835421 chr16:68378352 PRMT7 -0.54 -6.09 -0.32 3.03e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg00800038 chr16:89945340 TCF25 -0.75 -6.52 -0.34 2.56e-10 Skin colour saturation; LUSC cis rs3736594 1.000 rs3736594 chr2:27995781 A/C cg27432699 chr2:27873401 GPN1 -0.61 -8.9 -0.44 3.65e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7582180 0.630 rs13021801 chr2:100935129 C/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.49 -0.42 6.65e-16 Intelligence (multi-trait analysis); LUSC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg12311346 chr5:56204834 C5orf35 -0.63 -9.14 -0.45 6.27e-18 Coronary artery disease; LUSC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs10089 0.552 rs17607942 chr5:127555435 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 8.71 0.43 1.47e-16 Ileal carcinoids; LUSC cis rs9300255 0.602 rs11057192 chr12:123693420 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg21782813 chr7:2030301 MAD1L1 0.57 10.33 0.49 7.03e-22 Bipolar disorder and schizophrenia; LUSC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg15556689 chr8:8085844 FLJ10661 0.46 5.79 0.3 1.61e-8 Obesity-related traits; LUSC cis rs1712517 0.836 rs7093039 chr10:105149547 A/G cg05636881 chr10:105038444 INA 0.41 6.81 0.35 4.43e-11 Migraine; LUSC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg10909506 chr17:38081995 ORMDL3 0.33 5.98 0.31 5.81e-9 Self-reported allergy; LUSC cis rs3741151 0.892 rs7930454 chr11:73085034 T/C cg17517138 chr11:73019481 ARHGEF17 0.83 7.55 0.38 4.15e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs11112613 0.713 rs11112588 chr12:105943801 A/C cg03607813 chr12:105948248 NA 0.79 11.55 0.53 3.54e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs58235267 0.656 rs12713469 chr2:63059927 C/T cg17519650 chr2:63277830 OTX1 -0.7 -9.67 -0.47 1.15e-19 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg07061783 chr6:25882402 NA -0.5 -6.68 -0.34 1.02e-10 Intelligence (multi-trait analysis); LUSC cis rs7681423 0.951 rs13130318 chr4:155538470 T/G cg20735720 chr4:155535218 FGG -0.52 -7.53 -0.38 4.87e-13 Fibrinogen; LUSC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11890956 chr21:40555474 PSMG1 -0.73 -11.15 -0.52 9.02e-25 Menarche (age at onset); LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg16145915 chr7:1198662 ZFAND2A 0.59 11.2 0.52 6.09e-25 Longevity;Endometriosis; LUSC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg16606324 chr3:10149918 C3orf24 0.68 9.9 0.48 2.05e-20 Alzheimer's disease; LUSC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -10.01 -0.48 8.56e-21 Personality dimensions; LUSC trans rs61931739 0.817 rs866515 chr12:34215479 A/G cg13010199 chr12:38710504 ALG10B 0.4 6.28 0.32 1.06e-9 Morning vs. evening chronotype; LUSC cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg24642439 chr20:33292090 TP53INP2 0.52 7.83 0.39 6.4e-14 Coronary artery disease; LUSC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg06713675 chr4:122721982 EXOSC9 0.46 8.24 0.41 4.1e-15 Type 2 diabetes; LUSC cis rs7267979 1.000 rs6107046 chr20:25442049 G/A cg03522245 chr20:25566470 NINL 0.35 5.66 0.3 3.26e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7173743 0.967 rs28694044 chr15:79134718 A/T cg00540400 chr15:79124168 NA -0.33 -5.67 -0.3 3.08e-8 Coronary artery disease; LUSC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg17294928 chr15:75287854 SCAMP5 0.41 5.85 0.3 1.2e-8 Breast cancer; LUSC cis rs1348850 0.872 rs12991272 chr2:178457339 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.88 0.31 9.93e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.63 0.39 2.54e-13 Major depressive disorder; LUSC cis rs2677744 0.719 rs1266492 chr15:91456102 T/C cg23684204 chr15:91497937 RCCD1 0.43 6.18 0.32 1.83e-9 Attention deficit hyperactivity disorder; LUSC cis rs3020736 0.500 rs28791586 chr22:42500483 A/G cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.3 -5.71 -0.3 2.53e-8 Schizophrenia; LUSC cis rs3540 0.574 rs2657946 chr15:90967513 G/C cg04176472 chr15:90893244 GABARAPL3 0.34 6.2 0.32 1.7e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4499344 0.921 rs12982788 chr19:33085501 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.6 -7.75 -0.39 1.13e-13 Mean platelet volume; LUSC cis rs796364 0.951 rs36086821 chr2:201067436 G/A cg23649088 chr2:200775458 C2orf69 0.49 6.77 0.35 5.85e-11 Schizophrenia; LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.54 0.34 2.27e-10 Mean platelet volume; LUSC trans rs6951245 1.000 rs78896566 chr7:1080182 C/G cg13565492 chr6:43139072 SRF -0.56 -6.01 -0.31 4.81e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs782590 0.935 rs10460508 chr2:55882565 A/C cg03859395 chr2:55845619 SMEK2 0.88 16.56 0.67 2.26e-45 Metabolic syndrome; LUSC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg13393036 chr8:95962371 TP53INP1 -0.44 -9.17 -0.45 5.12e-18 Type 2 diabetes; LUSC cis rs6598955 0.543 rs61608823 chr1:26555090 G/A cg04990556 chr1:26633338 UBXN11 0.88 11.59 0.54 2.55e-26 Obesity-related traits; LUSC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg02569458 chr12:86230093 RASSF9 0.59 10.15 0.49 2.81e-21 Major depressive disorder; LUSC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg12963246 chr6:28129442 ZNF389 -0.57 -7.96 -0.4 2.74e-14 Parkinson's disease; LUSC cis rs72781680 0.898 rs72790310 chr2:24116716 C/T cg08917208 chr2:24149416 ATAD2B 0.87 9.73 0.47 7.07e-20 Lymphocyte counts; LUSC cis rs897984 0.568 rs8050107 chr16:30893451 C/T cg02466173 chr16:30829666 NA 0.52 8.42 0.42 1.14e-15 Dementia with Lewy bodies; LUSC cis rs6500395 1.000 rs9936454 chr16:48617782 T/G cg04672837 chr16:48644449 N4BP1 0.49 7.4 0.38 1.15e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs72960926 0.744 rs72959653 chr6:75012112 C/T cg03266952 chr6:74778945 NA -0.78 -6.76 -0.35 6.21e-11 Metabolite levels (MHPG); LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg14092988 chr3:52407081 DNAH1 0.31 6.14 0.32 2.33e-9 Bipolar disorder; LUSC cis rs11997175 1.000 rs6468203 chr8:33749572 T/A ch.8.33884649F chr8:33765107 NA 0.52 8.32 0.41 2.29e-15 Body mass index; LUSC cis rs9814567 0.762 rs13071852 chr3:134223217 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 11.91 0.55 1.75e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg11494091 chr17:61959527 GH2 0.64 13.56 0.6 1.12e-33 Prudent dietary pattern; LUSC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg22968622 chr17:43663579 NA 0.79 12.27 0.56 7.76e-29 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs17401966 0.838 rs1556916 chr1:10403482 G/A cg19773385 chr1:10388646 KIF1B -0.49 -8.61 -0.43 2.84e-16 Hepatocellular carcinoma; LUSC trans rs62238980 0.614 rs41430344 chr22:32381973 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.52 -5.94 -0.31 7e-9 Childhood ear infection; LUSC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg17264618 chr3:40429014 ENTPD3 0.36 7.38 0.37 1.26e-12 Renal cell carcinoma; LUSC trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg15704280 chr7:45808275 SEPT13 0.88 12.64 0.57 3.48e-30 Coronary artery disease; LUSC cis rs2404618 0.593 rs7815979 chr8:1484887 A/G cg02903104 chr8:1507517 DLGAP2 0.35 6.9 0.35 2.6e-11 Lung cancer; LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg26338869 chr17:61819248 STRADA 0.42 6.18 0.32 1.88e-9 Prudent dietary pattern; LUSC cis rs8114671 0.967 rs6088747 chr20:33754604 G/T cg07148914 chr20:33460835 GGT7 0.44 6.57 0.34 1.92e-10 Height; LUSC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg27170947 chr2:26402098 FAM59B -0.64 -9.34 -0.45 1.43e-18 Gut microbiome composition (summer); LUSC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg04539111 chr16:67997858 SLC12A4 -0.45 -6.06 -0.31 3.75e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs10743315 0.778 rs965861 chr12:19360719 A/G cg02471346 chr12:19282374 PLEKHA5 -0.49 -6.24 -0.32 1.3e-9 Gut microbiota (bacterial taxa); LUSC cis rs1577917 1.000 rs7756203 chr6:86627707 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC cis rs8072100 1.000 rs4794048 chr17:45763073 A/C cg08085267 chr17:45401833 C17orf57 -0.59 -10.14 -0.49 2.99e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3764563 1.000 rs4808326 chr19:15726147 A/G cg20725493 chr19:15740067 CYP4F8 -0.66 -7.03 -0.36 1.17e-11 Inflammatory biomarkers; LUSC cis rs1941023 0.503 rs12798266 chr11:60118851 G/A cg08716584 chr11:60157161 MS4A7 -0.59 -10.86 -0.51 9.87e-24 Congenital heart disease (maternal effect); LUSC cis rs2115630 1.000 rs8037423 chr15:85355494 C/T cg11189052 chr15:85197271 WDR73 -0.41 -5.91 -0.31 8.47e-9 P wave terminal force; LUSC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg26408565 chr15:76604113 ETFA -0.48 -7.54 -0.38 4.33e-13 Blood metabolite levels; LUSC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg05084668 chr3:125655381 ALG1L -0.5 -7.04 -0.36 1.11e-11 Blood pressure (smoking interaction); LUSC cis rs908922 0.676 rs4112785 chr1:152533115 G/C cg20991723 chr1:152506922 NA 0.5 9.18 0.45 4.77e-18 Hair morphology; LUSC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg08470875 chr2:26401718 FAM59B -0.66 -8.63 -0.43 2.55e-16 Gut microbiome composition (summer); LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg22920501 chr2:26401640 FAM59B -0.82 -12.42 -0.56 2.25e-29 Gut microbiome composition (summer); LUSC cis rs12220238 1.000 rs11000900 chr10:75918440 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.57 6.78 0.35 5.33e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7605827 0.897 rs4668922 chr2:15675130 C/T cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.79e-17 Educational attainment (years of education); LUSC cis rs9818758 0.607 rs13068038 chr3:49294250 C/A cg00383909 chr3:49044727 WDR6 1.18 10.79 0.51 1.76e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg14205524 chr15:42787946 SNAP23 0.39 5.94 0.31 7.02e-9 Triglycerides; LUSC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg04369109 chr6:150039330 LATS1 -0.42 -6.09 -0.32 3.17e-9 Testicular germ cell tumor; LUSC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg18099408 chr3:52552593 STAB1 -0.41 -6.95 -0.36 1.92e-11 Bipolar disorder; LUSC cis rs10489202 0.865 rs744168 chr1:168094079 G/T cg24449463 chr1:168025552 DCAF6 -0.57 -6.9 -0.35 2.66e-11 Schizophrenia; LUSC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg09323728 chr8:95962352 TP53INP1 -0.3 -5.7 -0.3 2.69e-8 Type 2 diabetes; LUSC cis rs12900413 0.687 rs28435184 chr15:90306732 T/C cg24249390 chr15:90295951 MESP1 -0.37 -5.92 -0.31 7.96e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs8067354 0.645 rs2102507 chr17:57875907 A/G cg02344993 chr17:57696989 CLTC 0.48 7.11 0.36 7.3e-12 Hemoglobin concentration; LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg16524733 chr11:117070046 TAGLN 0.43 7.34 0.37 1.67e-12 Blood protein levels; LUSC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.6 9.39 0.46 9.59e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7582720 1.000 rs72934749 chr2:203746816 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg25456477 chr12:86230367 RASSF9 0.38 6.45 0.33 4.03e-10 Major depressive disorder; LUSC cis rs4851254 0.626 rs71413861 chr2:100673501 A/G cg07810366 chr2:100720526 AFF3 -0.47 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs965469 1.000 rs8123289 chr20:3253831 T/C cg25506879 chr20:3388711 C20orf194 -0.56 -6.29 -0.33 9.9e-10 IFN-related cytopenia; LUSC cis rs926938 0.527 rs360665 chr1:115478503 A/T cg01522456 chr1:115632236 TSPAN2 -0.41 -6.49 -0.33 3.08e-10 Autism; LUSC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg14552801 chr7:65878734 NA 0.38 5.84 0.3 1.24e-8 Aortic root size; LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg26304593 chr6:42947056 PEX6 -0.53 -8.31 -0.41 2.44e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg15448220 chr1:150897856 SETDB1 0.41 6.02 0.31 4.48e-9 Melanoma; LUSC cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg03146154 chr1:46216737 IPP 0.55 7.81 0.39 7.55e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg08847533 chr14:75593920 NEK9 0.85 15.55 0.65 2.07e-41 Height; LUSC cis rs9362426 0.708 rs4707367 chr6:88101188 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.39 -6.47 -0.33 3.55e-10 Depressive episodes in bipolar disorder; LUSC cis rs4803468 1.000 rs166925 chr19:41926098 T/C cg09537434 chr19:41945824 ATP5SL -0.92 -16.09 -0.66 1.58e-43 Height; LUSC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg20607287 chr7:12443886 VWDE -0.66 -6.5 -0.33 2.99e-10 Coronary artery disease; LUSC cis rs3755132 0.929 rs3770466 chr2:15758293 T/C cg12888861 chr2:15731646 DDX1 0.52 7.46 0.38 7.57e-13 Wilms tumor; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg16303686 chr3:132136102 DNAJC13 0.77 6.18 0.32 1.89e-9 Cognitive performance; LUSC cis rs3760982 0.813 rs8104447 chr19:44293278 T/C cg11993925 chr19:44307056 LYPD5 -0.31 -6.86 -0.35 3.39e-11 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC trans rs7939886 0.920 rs11227507 chr11:55972274 G/A cg15704280 chr7:45808275 SEPT13 0.91 6.86 0.35 3.36e-11 Myopia (pathological); LUSC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs9303542 0.625 rs17703660 chr17:46567134 T/C cg09704116 chr17:46666958 LOC404266 -0.38 -6.43 -0.33 4.51e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC trans rs9329221 1.000 rs9329221 chr8:10240202 G/T cg06636001 chr8:8085503 FLJ10661 0.5 7.52 0.38 5.04e-13 Neuroticism; LUSC cis rs75804782 0.581 rs3191996 chr2:239344412 A/G cg18131467 chr2:239335373 ASB1 0.7 6.49 0.33 3.19e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15378786 chr11:17036137 PLEKHA7 0.9 16.92 0.68 8.31e-47 Coronary artery disease; LUSC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg14004847 chr7:1930337 MAD1L1 -0.51 -7.84 -0.39 5.96e-14 Schizophrenia; LUSC cis rs8017423 1.000 rs2183189 chr14:90670057 A/G cg14092571 chr14:90743983 NA -0.35 -5.77 -0.3 1.84e-8 Mortality in heart failure; LUSC trans rs6502050 0.835 rs3088177 chr17:80111724 A/G cg07393940 chr7:158741817 NA 0.36 6.47 0.33 3.44e-10 Life satisfaction; LUSC cis rs9513627 0.915 rs73556173 chr13:100121766 C/T cg25919922 chr13:100150906 NA -0.8 -6.96 -0.36 1.83e-11 Obesity-related traits; LUSC cis rs3740540 0.507 rs897292 chr10:126290035 A/G cg04949429 chr10:126290192 LHPP 0.36 7.71 0.39 1.44e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC cis rs9581857 0.519 rs9581880 chr13:28105850 C/A cg22138327 chr13:27999177 GTF3A 0.66 7.22 0.37 3.44e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg26380479 chr7:97908229 NA -0.28 -6.13 -0.32 2.54e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg01097406 chr16:89675127 NA -0.34 -6.82 -0.35 4.39e-11 Vitiligo; LUSC cis rs9905704 0.918 rs304271 chr17:56802458 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.75 0.39 1.15e-13 Testicular germ cell tumor; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10475689 chr16:12142335 RUNDC2A 0.49 6.45 0.33 3.99e-10 Bipolar disorder and schizophrenia; LUSC trans rs9291683 0.530 rs35908990 chr4:9976105 G/A cg26043149 chr18:55253948 FECH 0.47 7.16 0.36 5.06e-12 Bone mineral density; LUSC cis rs6500602 0.964 rs2304633 chr16:4496973 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 6.38 0.33 5.99e-10 Schizophrenia; LUSC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg12963246 chr6:28129442 ZNF389 0.48 6.68 0.34 9.77e-11 Depression; LUSC trans rs9393777 0.920 rs13195040 chr6:27413924 C/T cg01620082 chr3:125678407 NA 0.76 7.1 0.36 7.41e-12 Intelligence (multi-trait analysis); LUSC cis rs17092148 1.000 rs6060043 chr20:33364584 C/T cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg17948913 chr5:572064 NA 0.33 5.66 0.3 3.27e-8 Ulcerative colitis; LUSC cis rs11229555 0.645 rs4506677 chr11:58213852 T/C cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs854765 0.624 rs12952723 chr17:17731651 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.71 -11.94 -0.55 1.27e-27 Total body bone mineral density; LUSC cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg24450063 chr1:156163899 SLC25A44 1.07 17.34 0.69 1.71e-48 Testicular germ cell tumor; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg04571355 chr1:201489142 RPS10P7 -0.39 -6.92 -0.35 2.26e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs981844 0.775 rs1020704 chr4:154736494 C/T cg14289246 chr4:154710475 SFRP2 0.48 6.53 0.34 2.38e-10 Response to statins (LDL cholesterol change); LUSC trans rs877282 1.000 rs12773872 chr10:771939 T/C cg22713356 chr15:30763199 NA 1.11 15.31 0.64 1.94e-40 Uric acid levels; LUSC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.76 11.02 0.52 2.77e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.42 5.75 0.3 1.97e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12594515 1.000 rs6493172 chr15:45987213 T/G cg19682013 chr15:45996608 NA 0.4 6.05 0.31 3.79e-9 Waist circumference;Weight; LUSC cis rs3741151 1.000 rs76764824 chr11:73073580 C/T cg17517138 chr11:73019481 ARHGEF17 1.11 9.05 0.44 1.23e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2742234 0.541 rs7098236 chr10:43740508 T/C cg15436174 chr10:43711423 RASGEF1A 0.43 6.94 0.36 2.02e-11 Hirschsprung disease; LUSC cis rs12620999 0.941 rs1986830 chr2:237978320 C/T cg23555395 chr2:238036564 NA 0.44 7.7 0.39 1.59e-13 Systemic lupus erythematosus; LUSC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg08888203 chr3:10149979 C3orf24 0.67 9.34 0.46 1.37e-18 Alzheimer's disease; LUSC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.29 -5.69 -0.3 2.74e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs7615952 0.688 rs12485622 chr3:125710739 T/C cg07211511 chr3:129823064 LOC729375 -0.8 -10.65 -0.5 5.31e-23 Blood pressure (smoking interaction); LUSC cis rs7809950 0.678 rs7803151 chr7:106934246 G/A cg23024343 chr7:107201750 COG5 -0.66 -9.99 -0.48 9.74e-21 Coronary artery disease; LUSC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg27535305 chr1:53392650 SCP2 -0.4 -7.7 -0.39 1.52e-13 Monocyte count; LUSC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.49 -0.33 3.17e-10 Schizophrenia; LUSC cis rs8099014 0.954 rs28497563 chr18:56134147 C/A cg12907477 chr18:56117327 MIR122 0.43 6.55 0.34 2.21e-10 Platelet count; LUSC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg19318889 chr4:1322082 MAEA 0.49 8.05 0.4 1.5e-14 Obesity-related traits; LUSC cis rs8013055 0.846 rs10136015 chr14:105973469 A/C cg19700328 chr14:106028568 NA -0.41 -6.94 -0.36 1.99e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs3815700 1.000 rs7260624 chr19:33096562 A/G cg02997394 chr19:33096574 ANKRD27 0.82 9.28 0.45 2.14e-18 Eosinophilic esophagitis; LUSC cis rs2404602 0.536 rs1587381 chr15:76769620 G/A cg26408565 chr15:76604113 ETFA -0.53 -8.38 -0.42 1.45e-15 Blood metabolite levels; LUSC cis rs7927592 0.913 rs7102898 chr11:68328870 G/A cg20283391 chr11:68216788 NA -0.6 -8.4 -0.42 1.25e-15 Total body bone mineral density; LUSC cis rs35146811 0.695 rs1727132 chr7:99812297 T/C cg13334819 chr7:99746414 C7orf59 0.5 6.79 0.35 5.04e-11 Coronary artery disease; LUSC cis rs7100689 0.784 rs11202699 chr10:82131453 A/G cg01528321 chr10:82214614 TSPAN14 1.03 16.02 0.66 3.03e-43 Post bronchodilator FEV1; LUSC cis rs1775715 0.870 rs1775737 chr10:32256871 T/C cg18675610 chr10:32216311 ARHGAP12 0.28 5.93 0.31 7.38e-9 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs1941687 0.831 rs35740221 chr18:31387714 T/G cg27147174 chr7:100797783 AP1S1 -0.46 -6.78 -0.35 5.62e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs6087990 0.806 rs4911258 chr20:31369479 G/A cg13636640 chr20:31349939 DNMT3B 0.89 17.61 0.69 1.43e-49 Ulcerative colitis; LUSC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg20573242 chr4:122745356 CCNA2 0.64 9.38 0.46 1.04e-18 Type 2 diabetes; LUSC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 9.43 0.46 6.92e-19 Mean platelet volume; LUSC cis rs965469 0.947 rs6051692 chr20:3244098 T/C cg25506879 chr20:3388711 C20orf194 -0.56 -6.38 -0.33 5.98e-10 IFN-related cytopenia; LUSC trans rs1814175 0.935 rs11040463 chr11:49685574 C/T cg03929089 chr4:120376271 NA -1.0 -18.23 -0.71 4.89e-52 Height; LUSC cis rs2425143 0.730 rs6058354 chr20:34491110 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.67 -0.3 3.14e-8 Blood protein levels; LUSC cis rs950169 0.881 rs62029599 chr15:84956565 A/C cg12863693 chr15:85201151 NMB 0.36 7.06 0.36 9.44e-12 Schizophrenia; LUSC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg22823121 chr1:150693482 HORMAD1 -0.45 -6.53 -0.34 2.47e-10 Melanoma; LUSC cis rs4805272 0.512 rs7245724 chr19:29341679 C/T cg04546413 chr19:29218101 NA 0.58 7.23 0.37 3.31e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs6457821 1.000 rs114672225 chr6:35440288 G/A cg06087101 chr6:35551932 FKBP5 0.63 5.77 0.3 1.8e-8 Height; LUSC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg06713675 chr4:122721982 EXOSC9 -0.45 -7.97 -0.4 2.59e-14 Type 2 diabetes; LUSC cis rs1728785 1.000 rs698716 chr16:68560296 C/T cg02972257 chr16:68554789 NA -0.49 -6.3 -0.33 9.24e-10 Ulcerative colitis; LUSC cis rs5758659 0.652 rs133347 chr22:42423645 A/T cg04733989 chr22:42467013 NAGA 0.42 7.08 0.36 8.61e-12 Cognitive function; LUSC cis rs9427116 0.840 rs9427113 chr1:154626477 A/G cg17218026 chr1:154582156 ADAR 0.51 8.76 0.43 9.71e-17 Blood protein levels; LUSC cis rs9660992 0.789 rs1768584 chr1:205240145 A/G cg00857998 chr1:205179979 DSTYK 0.57 8.89 0.44 3.91e-17 Mean corpuscular volume;Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22024783 chr19:45393916 TOMM40 0.49 7.23 0.37 3.27e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11608355 1.000 rs10850135 chr12:109866528 C/A cg19025524 chr12:109796872 NA -0.39 -6.0 -0.31 5.04e-9 Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17330695 chr2:216973988 XRCC5 -0.44 -6.56 -0.34 2.03e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg18512352 chr11:47633146 NA -0.48 -9.65 -0.47 1.38e-19 Subjective well-being; LUSC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.59 0.5 8.66e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2067615 0.524 rs7959062 chr12:107107334 G/T cg19260189 chr12:106995001 RFX4 0.23 5.92 0.31 7.83e-9 Heart rate; LUSC cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg24130564 chr14:104152367 KLC1 -0.42 -5.94 -0.31 7.02e-9 Bone mineral density; LUSC cis rs2562456 0.833 rs2968078 chr19:21641744 A/G cg00806126 chr19:22604979 ZNF98 0.37 5.84 0.3 1.24e-8 Pain; LUSC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg17173187 chr15:85201210 NMB 0.37 6.52 0.34 2.64e-10 Schizophrenia; LUSC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg13939156 chr17:80058883 NA -0.32 -6.37 -0.33 6.34e-10 Life satisfaction; LUSC cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg25039879 chr17:56429692 SUPT4H1 0.5 7.83 0.39 6.47e-14 Primary tooth development (time to first tooth eruption); LUSC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg09796270 chr17:17721594 SREBF1 0.43 7.57 0.38 3.78e-13 Total body bone mineral density; LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg08888203 chr3:10149979 C3orf24 0.65 8.79 0.43 8.22e-17 Alzheimer's disease; LUSC cis rs2762353 0.935 rs1359232 chr6:25809716 C/A cg03517284 chr6:25882590 NA 0.43 7.76 0.39 1.07e-13 Blood metabolite levels; LUSC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg23758822 chr17:41437982 NA 0.99 19.95 0.74 7.12e-59 Menopause (age at onset); LUSC cis rs765787 0.530 rs2413780 chr15:45538866 A/G cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.3e-11 Uric acid levels; LUSC cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg01579765 chr21:45077557 HSF2BP -0.51 -10.94 -0.51 5.22e-24 Mean corpuscular volume; LUSC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 14.38 0.62 7.93e-37 Platelet count; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg22870994 chr11:71340352 NA -0.41 -5.99 -0.31 5.51e-9 Neuroticism; LUSC cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg22681709 chr2:178499509 PDE11A -0.51 -8.92 -0.44 3.09e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11190604 1.000 rs2295770 chr10:102239829 G/A cg16342193 chr10:102329863 NA -0.35 -6.3 -0.33 9.17e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg07636037 chr3:49044803 WDR6 0.88 13.44 0.59 3.2e-33 Menarche (age at onset); LUSC cis rs1832871 0.711 rs9459918 chr6:158703604 A/C cg07165851 chr6:158734300 TULP4 0.5 7.72 0.39 1.36e-13 Height; LUSC cis rs17253792 0.822 rs76918910 chr14:56058762 T/C cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs977987 0.806 rs4888416 chr16:75449176 C/G cg03315344 chr16:75512273 CHST6 0.48 8.94 0.44 2.68e-17 Dupuytren's disease; LUSC cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg09307838 chr4:120376055 NA -0.74 -10.89 -0.51 7.56e-24 Corneal astigmatism; LUSC trans rs11039798 0.925 rs12277669 chr11:48925316 A/T cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs977987 0.806 rs4888386 chr16:75389740 A/G cg04384234 chr16:75411784 CFDP1 -0.4 -6.46 -0.33 3.68e-10 Dupuytren's disease; LUSC cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg27279351 chr12:120934652 DYNLL1 0.63 8.39 0.42 1.42e-15 High light scatter reticulocyte count; LUSC cis rs9346649 0.630 rs6913441 chr6:168491271 C/T cg02770688 chr6:168491649 NA 0.5 9.54 0.46 3e-19 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC trans rs61931739 0.890 rs1705753 chr12:34144594 C/T cg13010199 chr12:38710504 ALG10B 0.44 7.08 0.36 8.41e-12 Morning vs. evening chronotype; LUSC cis rs4494114 0.936 rs9439092 chr1:39375157 T/G cg25970120 chr1:39325951 RRAGC -0.4 -6.22 -0.32 1.47e-9 Blood protein levels; LUSC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg04756594 chr16:24857601 SLC5A11 0.49 7.19 0.37 4.4e-12 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9326248 0.911 rs474339 chr11:117059552 G/A cg16524733 chr11:117070046 TAGLN 0.44 7.53 0.38 4.89e-13 Blood protein levels; LUSC trans rs17685 0.712 rs10275521 chr7:75770972 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg20283391 chr11:68216788 NA -0.53 -7.94 -0.4 3.19e-14 Total body bone mineral density; LUSC cis rs7264396 0.563 rs2425079 chr20:34298191 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.62 -0.43 2.78e-16 Total cholesterol levels; LUSC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg12463550 chr7:65579703 CRCP 0.43 6.06 0.31 3.74e-9 Calcium levels; LUSC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg08270630 chr22:50330655 NA 0.4 5.9 0.31 8.78e-9 Schizophrenia; LUSC cis rs688020 1.000 rs688020 chr7:4228553 C/T cg02004499 chr7:4244250 SDK1 0.48 7.73 0.39 1.25e-13 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; LUSC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.0 0.52 3.23e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7312933 0.524 rs11181465 chr12:42765098 T/G cg17420585 chr12:42539391 GXYLT1 -0.3 -5.71 -0.3 2.54e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.09 0.4 1.12e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg20243544 chr17:37824526 PNMT 0.41 6.37 0.33 6.21e-10 Self-reported allergy; LUSC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg12463550 chr7:65579703 CRCP -0.49 -7.22 -0.37 3.63e-12 Aortic root size; LUSC cis rs6582630 0.593 rs12816835 chr12:38533304 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.27 -0.41 3.3e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs4129767 0.869 rs4969142 chr17:76398304 G/A cg05887092 chr17:76393375 PGS1 0.67 13.24 0.59 1.92e-32 HDL cholesterol; LUSC cis rs9815354 0.597 rs80066790 chr3:42000843 A/G cg03022575 chr3:42003672 ULK4 0.81 8.43 0.42 1.06e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg20849893 chr7:64541193 NA -0.65 -5.68 -0.3 2.99e-8 Diabetic kidney disease; LUSC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg06671706 chr8:8559999 CLDN23 0.51 6.65 0.34 1.18e-10 Obesity-related traits; LUSC cis rs911555 0.723 rs56227024 chr14:103861706 A/G cg12935359 chr14:103987150 CKB 0.68 10.99 0.52 3.53e-24 Intelligence (multi-trait analysis); LUSC trans rs12637928 0.580 rs7638452 chr3:110180719 A/G cg17371621 chr15:61264283 RORA 0.38 6.38 0.33 5.74e-10 Neuroticism; LUSC cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg13010199 chr12:38710504 ALG10B 0.67 10.31 0.49 8.3e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.45 0.67 5.97e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9653442 0.866 rs11123811 chr2:100760172 T/C cg07810366 chr2:100720526 AFF3 -0.52 -9.08 -0.45 9.54e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7223966 0.883 rs2727317 chr17:61961302 C/T cg11494091 chr17:61959527 GH2 0.38 6.24 0.32 1.31e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1538970 0.924 rs7531253 chr1:45890183 T/C cg05343316 chr1:45956843 TESK2 0.64 8.86 0.44 4.88e-17 Platelet count; LUSC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg12442385 chr7:1034912 NA -0.36 -6.09 -0.32 3.02e-9 Longevity;Endometriosis; LUSC cis rs13253111 0.624 rs28372101 chr8:28099384 G/T cg26534493 chr8:28060551 NA 0.37 6.82 0.35 4.35e-11 Childhood body mass index; LUSC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11644478 chr21:40555479 PSMG1 0.62 9.37 0.46 1.11e-18 Menarche (age at onset); LUSC trans rs561341 0.660 rs7406043 chr17:30220152 C/G cg20587970 chr11:113659929 NA -1.06 -13.08 -0.58 7.3e-32 Hip circumference adjusted for BMI; LUSC cis rs6964587 1.000 rs35653487 chr7:91745441 C/G cg01689657 chr7:91764605 CYP51A1 0.34 6.19 0.32 1.79e-9 Breast cancer; LUSC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg16520312 chr17:43971471 MAPT;LOC100128977 0.35 5.95 0.31 6.93e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg05623727 chr3:50126028 RBM5 -0.35 -6.66 -0.34 1.1e-10 Body mass index; LUSC cis rs11190604 1.000 rs2495734 chr10:102338686 G/A cg07080220 chr10:102295463 HIF1AN 0.67 8.9 0.44 3.54e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg12963246 chr6:28129442 ZNF389 -0.44 -6.34 -0.33 7.6e-10 Depression; LUSC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg22433210 chr17:43662623 NA -0.74 -10.73 -0.51 2.92e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg27295185 chr5:154320610 MRPL22 0.43 6.77 0.35 5.87e-11 Schizophrenia; LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.06 -0.58 8.6e-32 Alzheimer's disease; LUSC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.74 11.02 0.52 2.64e-24 Multiple sclerosis; LUSC cis rs4901869 0.966 rs431343 chr14:59345530 C/T cg02291164 chr14:59296302 NA 0.53 9.57 0.46 2.5e-19 Panic disorder; LUSC cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.33e-32 Chronic sinus infection; LUSC cis rs7524258 0.835 rs75096060 chr1:7270248 G/C cg07173049 chr1:7289937 CAMTA1 0.33 6.72 0.35 7.64e-11 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs11648785 0.661 rs870856 chr16:90089463 C/G cg16611967 chr16:90144006 NA 0.46 6.26 0.32 1.15e-9 Tanning; LUSC cis rs57502260 0.834 rs3736228 chr11:68201295 A/G cg20283391 chr11:68216788 NA 0.61 5.86 0.31 1.08e-8 Total body bone mineral density (age 45-60); LUSC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg17554472 chr22:41940697 POLR3H -0.48 -5.94 -0.31 7.16e-9 Vitiligo; LUSC cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg01579765 chr21:45077557 HSF2BP -0.5 -10.59 -0.5 8.88e-23 Mean corpuscular volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08340572 chr15:76196139 FBXO22 0.42 6.17 0.32 2.01e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2439831 0.867 rs76542740 chr15:43891512 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.74 7.12 0.36 6.78e-12 Lung cancer in ever smokers; LUSC cis rs11098499 0.566 rs7664440 chr4:120578540 A/G cg09307838 chr4:120376055 NA 0.7 9.91 0.48 1.9e-20 Corneal astigmatism; LUSC cis rs1865721 1.000 rs72977888 chr18:73195250 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -7.97 -0.4 2.56e-14 Intelligence; LUSC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg05855489 chr10:104503620 C10orf26 -0.7 -10.37 -0.49 4.99e-22 Allergic disease (asthma, hay fever or eczema); LUSC trans rs12188164 0.965 rs11745789 chr5:450777 T/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs3768617 0.903 rs10911251 chr1:183081194 A/C ch.1.3577855R chr1:183094577 LAMC1 0.59 8.4 0.42 1.26e-15 Fuchs's corneal dystrophy; LUSC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg20821713 chr7:1055600 C7orf50 -0.45 -5.87 -0.31 1.05e-8 Bronchopulmonary dysplasia; LUSC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg19077165 chr18:44547161 KATNAL2 -0.41 -6.25 -0.32 1.26e-9 Personality dimensions; LUSC cis rs9467773 0.620 rs2504540 chr6:26641626 A/G cg09904177 chr6:26538194 HMGN4 0.66 11.63 0.54 1.81e-26 Intelligence (multi-trait analysis); LUSC trans rs11700980 0.551 rs2832029 chr21:30114574 G/A cg14791747 chr16:20752902 THUMPD1 0.56 6.1 0.32 2.98e-9 QRS complex (12-leadsum); LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg14895029 chr7:2775587 GNA12 -0.42 -6.37 -0.33 6.31e-10 Height; LUSC cis rs79911532 0.515 rs117982500 chr7:75758907 C/A cg03592824 chr7:75666768 STYXL1 0.67 6.37 0.33 6.32e-10 Mononucleosis; LUSC cis rs2070488 0.775 rs2070489 chr3:38519424 A/G cg24069376 chr3:38537580 EXOG 0.42 8.05 0.4 1.51e-14 Electrocardiographic conduction measures; LUSC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg03806693 chr22:41940476 POLR3H -1.04 -14.67 -0.63 5.92e-38 Vitiligo; LUSC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg16145915 chr7:1198662 ZFAND2A -0.43 -6.27 -0.32 1.12e-9 Bronchopulmonary dysplasia; LUSC cis rs10751667 0.643 rs7395592 chr11:934094 C/G ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs354225 0.544 rs12713265 chr2:54805409 C/T cg26097391 chr2:54893211 SPTBN1 0.45 6.89 0.35 2.83e-11 Schizophrenia; LUSC cis rs13067593 1.000 rs35687668 chr3:188573711 T/G cg17809494 chr3:188572244 LPP 0.42 5.7 0.3 2.57e-8 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs9487051 0.735 rs1761608 chr6:109517706 G/A cg01475377 chr6:109611718 NA -0.36 -6.12 -0.32 2.66e-9 Reticulocyte fraction of red cells; LUSC cis rs614226 0.872 rs787827 chr12:120937794 A/G cg27489772 chr12:121021490 NA 0.58 7.71 0.39 1.44e-13 Type 1 diabetes nephropathy; LUSC cis rs1957429 0.808 rs11628910 chr14:65332392 A/G cg23373153 chr14:65346875 NA 0.95 10.83 0.51 1.25e-23 Pediatric areal bone mineral density (radius); LUSC trans rs11696501 0.739 rs6073784 chr20:44201931 T/A cg03272292 chr12:48577362 C12orf68 0.51 5.98 0.31 5.86e-9 Brain structure; LUSC trans rs61931739 0.500 rs7955933 chr12:34473608 A/G cg13010199 chr12:38710504 ALG10B 0.58 9.13 0.45 6.73e-18 Morning vs. evening chronotype; LUSC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg24829409 chr8:58192753 C8orf71 -0.63 -6.58 -0.34 1.79e-10 Developmental language disorder (linguistic errors); LUSC cis rs12997796 1.000 rs12997796 chr2:86974318 A/G cg25203885 chr2:87302643 LOC285074 -0.61 -6.84 -0.35 3.87e-11 Schizophrenia; LUSC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg08088566 chr11:430123 ANO9 0.61 7.04 0.36 1.07e-11 Body mass index; LUSC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg20833759 chr3:49053208 WDR6;DALRD3 0.53 7.88 0.4 4.72e-14 Menarche (age at onset); LUSC cis rs6977660 1.000 rs10279525 chr7:19822305 C/T cg07541023 chr7:19748670 TWISTNB 0.51 5.74 0.3 2.08e-8 Thyroid stimulating hormone; LUSC cis rs9329221 0.662 rs11249996 chr8:10245463 G/T cg27411982 chr8:10470053 RP1L1 -0.47 -7.02 -0.36 1.24e-11 Neuroticism; LUSC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg06112835 chr11:68658793 MRPL21 0.5 7.9 0.4 4.19e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9640161 0.789 rs10248490 chr7:150051418 C/G cg27494647 chr7:150038898 RARRES2 0.44 6.77 0.35 5.88e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2439831 0.681 rs526450 chr15:43599325 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.04 15.29 0.64 2.22e-40 Lung cancer in ever smokers; LUSC cis rs3020736 0.500 rs6002597 chr22:42488160 C/A cg15557168 chr22:42548783 NA 0.46 7.12 0.36 6.7e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs8060686 0.565 rs4359427 chr16:68202747 C/T cg05110241 chr16:68378359 PRMT7 -0.54 -6.34 -0.33 7.48e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs2243480 1.000 rs431318 chr7:65511597 G/A cg10756647 chr7:56101905 PSPH 0.85 8.25 0.41 3.59e-15 Diabetic kidney disease; LUSC cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg14343924 chr8:8086146 FLJ10661 -0.44 -6.18 -0.32 1.86e-9 Mood instability; LUSC cis rs9296092 0.538 rs112113649 chr6:33524529 A/G cg13560919 chr6:33536144 NA -0.84 -16.11 -0.66 1.37e-43 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs11030122 0.673 rs10835596 chr11:4099666 C/T cg18678763 chr11:4115507 RRM1 -0.48 -6.37 -0.33 6.3e-10 Mean platelet volume;Platelet distribution width; LUSC trans rs9860340 0.687 rs6806250 chr3:87651951 T/G cg03644585 chr7:884825 UNC84A 0.44 6.12 0.32 2.65e-9 Electroencephalographic traits in alcoholism; LUSC cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.44e-8 Intelligence (multi-trait analysis); LUSC cis rs3862030 0.720 rs1056744 chr10:104236687 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.59 -9.29 -0.45 2.04e-18 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6752107 1.000 rs2241878 chr2:234183718 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.69 11.55 0.53 3.45e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg00814883 chr7:100076585 TSC22D4 -0.73 -9.85 -0.47 2.85e-20 Platelet count; LUSC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg17971929 chr21:40555470 PSMG1 0.52 7.98 0.4 2.33e-14 Cognitive function; LUSC cis rs3020736 0.500 rs2413669 chr22:42507748 A/C cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs11971779 0.774 rs6467838 chr7:139043501 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 2.02e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4631830 0.720 rs898343 chr10:51505403 A/G cg10326726 chr10:51549505 MSMB 0.35 6.08 0.32 3.37e-9 Prostate-specific antigen levels; LUSC cis rs4842666 0.831 rs11105337 chr12:89993507 A/T cg00757033 chr12:89920650 WDR51B 0.45 6.26 0.32 1.21e-9 Blood pressure; LUSC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.87 0.35 3.08e-11 Multiple sclerosis; LUSC cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg04034577 chr2:241836375 C2orf54 -0.48 -8.81 -0.43 7.08e-17 Urinary metabolites; LUSC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg17366294 chr4:99064904 C4orf37 0.56 10.0 0.48 8.92e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg08847533 chr14:75593920 NEK9 -0.85 -14.91 -0.63 7.11e-39 Height; LUSC cis rs9527 0.590 rs10883830 chr10:104851285 G/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.61 -0.34 1.54e-10 Arsenic metabolism; LUSC cis rs3806843 1.000 rs3733708 chr5:140181734 A/G cg19875535 chr5:140030758 IK 0.49 8.14 0.41 7.85e-15 Depressive symptoms (multi-trait analysis); LUSC trans rs12692738 0.526 rs355864 chr2:165630414 A/T cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4308124 0.708 rs56693625 chr2:111965155 G/A cg04571233 chr2:111982156 NA -0.51 -6.6 -0.34 1.62e-10 Vitiligo; LUSC cis rs1729951 0.575 rs361242 chr3:136698330 C/G cg21827317 chr3:136751795 NA 0.38 6.83 0.35 4.01e-11 Neuroticism; LUSC trans rs7939886 0.920 rs11231901 chr11:55811529 A/G cg15704280 chr7:45808275 SEPT13 0.84 6.97 0.36 1.68e-11 Myopia (pathological); LUSC cis rs722599 0.562 rs2193597 chr14:75234329 G/A cg08847533 chr14:75593920 NEK9 0.41 5.86 0.31 1.11e-8 IgG glycosylation; LUSC cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg25258033 chr6:167368657 RNASET2 0.42 6.69 0.34 9.53e-11 Crohn's disease; LUSC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg18479299 chr3:125709523 NA -0.49 -5.98 -0.31 5.67e-9 Blood pressure (smoking interaction); LUSC cis rs7903847 0.620 rs61863815 chr10:99124389 A/G cg08345082 chr10:99160200 RRP12 -0.36 -7.22 -0.37 3.46e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs983392 0.667 rs662196 chr11:59942757 C/T cg20284999 chr11:59952153 MS4A6A 0.35 6.08 0.32 3.34e-9 Alzheimer's disease (late onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04026000 chr5:79628372 NA 0.51 6.33 0.33 8.08e-10 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.25 0.37 2.92e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg12011299 chr4:100065546 ADH4 0.67 10.6 0.5 8.09e-23 Alcohol dependence; LUSC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03264133 chr6:25882463 NA -0.48 -8.04 -0.4 1.57e-14 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.05e-9 Crohn's disease; LUSC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg19592336 chr6:28129416 ZNF389 0.48 6.3 0.33 9.46e-10 Depression; LUSC cis rs9283706 0.548 rs10044452 chr5:66302605 C/T cg11590213 chr5:66331682 MAST4 0.43 6.53 0.34 2.4e-10 Coronary artery disease; LUSC cis rs3858526 0.792 rs12363478 chr11:5987775 C/T cg25319279 chr11:5960081 NA -0.45 -6.29 -0.33 1.01e-9 DNA methylation (variation); LUSC trans rs7824557 0.564 rs2736301 chr8:11236413 C/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.66e-10 Retinal vascular caliber; LUSC cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 8.15 0.41 7.6e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4343996 0.902 rs4349886 chr7:3370038 C/T cg21248987 chr7:3385318 SDK1 -0.37 -6.32 -0.33 8.33e-10 Motion sickness; LUSC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.11 14.28 0.62 1.9e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12148488 0.966 rs12899062 chr15:75347641 A/C cg10253484 chr15:75165896 SCAMP2 0.39 5.64 0.3 3.56e-8 Caffeine consumption; LUSC cis rs10979 0.631 rs12530338 chr6:143872563 C/T cg25407410 chr6:143891975 LOC285740 -0.52 -7.64 -0.39 2.27e-13 Hypospadias; LUSC cis rs11098499 0.644 rs6855918 chr4:120546299 C/T cg09307838 chr4:120376055 NA 0.63 9.5 0.46 4.35e-19 Corneal astigmatism; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg07507251 chr3:52567010 NT5DC2 0.32 6.25 0.32 1.28e-9 Bipolar disorder; LUSC cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg23029597 chr12:123009494 RSRC2 -0.74 -9.13 -0.45 6.67e-18 Body mass index; LUSC trans rs9860340 0.730 rs7617101 chr3:87633556 C/T cg03644585 chr7:884825 UNC84A 0.42 6.09 0.32 3.17e-9 Electroencephalographic traits in alcoholism; LUSC cis rs11190604 1.000 rs7100386 chr10:102301417 C/T cg16342193 chr10:102329863 NA -0.34 -5.94 -0.31 7.31e-9 Palmitoleic acid (16:1n-7) levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26036478 chr4:124319962 SPRY1 -0.45 -6.8 -0.35 4.93e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg03806693 chr22:41940476 POLR3H 0.94 13.9 0.61 5.76e-35 Vitiligo; LUSC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg06640241 chr16:89574553 SPG7 0.67 10.72 0.51 3.06e-23 Multiple myeloma (IgH translocation); LUSC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg13119609 chr19:45449297 APOC2 -0.51 -10.1 -0.48 4.1e-21 Blood protein levels; LUSC trans rs12692738 0.526 rs392050 chr2:165630793 G/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg14004847 chr7:1930337 MAD1L1 -0.49 -7.53 -0.38 4.65e-13 Bipolar disorder and schizophrenia; LUSC cis rs1150668 0.796 rs2247002 chr6:28397951 G/C cg21251018 chr6:28226885 NKAPL 0.31 5.91 0.31 8.57e-9 Pubertal anthropometrics; LUSC trans rs8073060 0.586 rs9303690 chr17:34005513 C/T cg19694781 chr19:47549865 TMEM160 -1.15 -18.51 -0.71 3.92e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2204008 0.660 rs2320745 chr12:38239101 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.12 0.48 3.51e-21 Bladder cancer; LUSC cis rs10489202 0.644 rs11584210 chr1:167846853 A/G cg24449463 chr1:168025552 DCAF6 -0.54 -6.37 -0.33 6.3e-10 Schizophrenia; LUSC cis rs1003719 0.788 rs1155785 chr21:38447939 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.42 0.53 9.82e-26 Eye color traits; LUSC cis rs68170813 0.559 rs6967745 chr7:106850548 G/T cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg21466736 chr12:48725269 NA -0.3 -5.7 -0.3 2.7e-8 Glycated hemoglobin levels; LUSC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg23205692 chr1:25664452 TMEM50A 0.4 5.85 0.31 1.15e-8 Erythrocyte sedimentation rate; LUSC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg18904891 chr8:8559673 CLDN23 0.6 8.13 0.41 8.6e-15 Obesity-related traits; LUSC cis rs2219968 1.000 rs1481511 chr8:78955014 A/G cg00738934 chr8:78996279 NA 0.34 6.17 0.32 1.94e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg06026331 chr20:60912101 LAMA5 0.61 7.32 0.37 1.81e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs61931739 0.500 rs7489130 chr12:34539674 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs7043114 0.525 rs2025388 chr9:95128740 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.82 -0.35 4.34e-11 Height; LUSC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg24209194 chr3:40518798 ZNF619 0.46 6.33 0.33 8.01e-10 Renal cell carcinoma; LUSC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg05855489 chr10:104503620 C10orf26 0.66 10.09 0.48 4.62e-21 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs11608355 0.515 rs6606727 chr12:109941450 T/A cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs1559088 0.749 rs10405757 chr19:33616526 C/A cg27124370 chr19:33622961 WDR88 0.54 7.16 0.36 5.12e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9916302 0.660 rs4795367 chr17:37608843 G/C cg07936489 chr17:37558343 FBXL20 -0.81 -9.89 -0.48 2.2e-20 Glomerular filtration rate (creatinine); LUSC cis rs9837602 1.000 rs13064704 chr3:99767541 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.49 6.15 0.32 2.19e-9 Breast cancer; LUSC cis rs6012953 0.817 rs16995294 chr20:49181345 T/A cg13958625 chr20:49123093 NA -0.26 -5.76 -0.3 1.91e-8 Vitiligo; LUSC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg16680214 chr1:154839983 KCNN3 -0.59 -11.49 -0.53 5.83e-26 Prostate cancer; LUSC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.79e-23 Schizophrenia; LUSC cis rs6964587 0.810 rs408 chr7:91556284 A/G cg17063962 chr7:91808500 NA -0.53 -8.15 -0.41 7.34e-15 Breast cancer; LUSC cis rs12477438 0.765 rs6722164 chr2:99561527 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.66 -0.57 2.91e-30 Chronic sinus infection; LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.28 0.53 3.21e-25 Prudent dietary pattern; LUSC cis rs9807989 1.000 rs9807989 chr2:102971200 T/C cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs4853525 0.923 rs2204859 chr2:191736873 C/A cg11845111 chr2:191398756 TMEM194B -0.42 -6.17 -0.32 1.93e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg17366294 chr4:99064904 C4orf37 0.55 8.99 0.44 1.94e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg06808227 chr14:105710500 BRF1 -0.69 -10.77 -0.51 2.11e-23 Mean platelet volume;Platelet distribution width; LUSC cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 13.05 0.58 9.94e-32 Platelet count; LUSC trans rs2832191 0.716 rs7284006 chr21:30475186 T/A cg14791747 chr16:20752902 THUMPD1 -0.4 -6.02 -0.31 4.49e-9 Dental caries; LUSC cis rs3125734 0.572 rs3864794 chr10:64041956 A/C cg09941381 chr10:64027924 RTKN2 -0.39 -7.12 -0.36 6.82e-12 Rheumatoid arthritis; LUSC cis rs11690935 0.798 rs13018768 chr2:172598592 A/G cg13550731 chr2:172543902 DYNC1I2 -0.86 -13.88 -0.6 6.6e-35 Schizophrenia; LUSC cis rs7804356 1.000 rs7785798 chr7:26861943 A/G cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg08997352 chr12:9597637 DDX12 -0.6 -9.5 -0.46 4.24e-19 Breast size; LUSC cis rs1692580 0.840 rs696094 chr1:2169215 G/A cg03732007 chr1:2071316 PRKCZ 0.4 6.49 0.33 3.07e-10 Coronary artery disease; LUSC cis rs62027291 0.654 rs56402836 chr15:77081967 A/C cg26408565 chr15:76604113 ETFA 0.78 7.02 0.36 1.25e-11 Plateletcrit; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01100864 chr12:122750645 VPS33A 0.46 6.12 0.32 2.58e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg11941060 chr3:133502564 NA 0.53 8.03 0.4 1.63e-14 Iron status biomarkers; LUSC cis rs11585357 0.895 rs72633808 chr1:17618665 A/G cg08277548 chr1:17600880 PADI3 -0.64 -6.64 -0.34 1.27e-10 Hair shape; LUSC trans rs62458065 0.850 rs62458098 chr7:32471129 G/A cg00845942 chr12:64062724 DPY19L2 -0.53 -6.08 -0.32 3.33e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9929218 0.529 rs11640736 chr16:68738324 G/T cg01251360 chr16:68772225 CDH1 -0.25 -5.92 -0.31 7.88e-9 Colorectal cancer; LUSC cis rs847577 0.609 rs34320230 chr7:97785500 C/T cg21770322 chr7:97807741 LMTK2 0.57 10.37 0.49 5.03e-22 Breast cancer; LUSC cis rs7607369 0.714 rs4674332 chr2:219604326 C/T cg02176678 chr2:219576539 TTLL4 0.66 12.75 0.57 1.36e-30 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg22800045 chr5:56110881 MAP3K1 0.67 9.13 0.45 6.52e-18 Initial pursuit acceleration; LUSC cis rs4356932 1.000 rs10014837 chr4:76941818 G/A cg00809888 chr4:76862425 NAAA 0.35 5.82 0.3 1.4e-8 Blood protein levels; LUSC cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg07606381 chr6:8435919 SLC35B3 0.75 12.89 0.58 3.77e-31 Motion sickness; LUSC cis rs11122272 0.735 rs2474630 chr1:231535335 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.0 -0.48 9.09e-21 Hemoglobin concentration; LUSC cis rs8064299 0.565 rs12453550 chr17:72786086 G/T cg25054828 chr17:72772726 NAT9;TMEM104 0.93 19.1 0.72 1.69e-55 Monocyte count; LUSC trans rs8073060 0.544 rs9912939 chr17:34005264 T/G cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7582180 0.629 rs12991172 chr2:100941671 A/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.6 -0.43 3.22e-16 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 11.54 0.53 3.72e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg07701084 chr6:150067640 NUP43 0.53 7.86 0.39 5.52e-14 Lung cancer; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg11905131 chr22:24372483 LOC391322 -0.6 -10.09 -0.48 4.65e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11971779 0.938 rs28477480 chr7:139036058 C/T cg07862535 chr7:139043722 LUC7L2 -0.65 -7.51 -0.38 5.38e-13 Diisocyanate-induced asthma; LUSC cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg20848291 chr7:100343083 ZAN -0.68 -9.4 -0.46 9.08e-19 Other erythrocyte phenotypes; LUSC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg11632617 chr15:75315747 PPCDC -0.52 -6.76 -0.35 6.09e-11 Blood trace element (Zn levels); LUSC cis rs7799006 1.000 rs7810970 chr7:2276385 A/G cg02951883 chr7:2050386 MAD1L1 -0.34 -5.81 -0.3 1.49e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11971779 0.648 rs9642121 chr7:139092621 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1691799 0.899 rs1168304 chr12:66738667 A/C cg16791601 chr12:66731901 HELB -0.73 -12.84 -0.57 5.97e-31 White blood cell count (basophil); LUSC cis rs62244186 0.545 rs9284880 chr3:44759389 C/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.54 8.38 0.42 1.48e-15 Depressive symptoms; LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.26 0.77 6.18e-68 Prudent dietary pattern; LUSC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.95 0.31 6.59e-9 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25134909 chr11:47587211 PTPMT1 0.48 6.59 0.34 1.72e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2324229 0.828 rs1180208 chr6:83954322 A/T cg08257003 chr6:84140564 ME1 0.28 6.75 0.35 6.49e-11 Platelet-derived growth factor BB levels; LUSC trans rs7824557 0.564 rs7821459 chr8:11236681 T/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.83 -0.39 6.41e-14 Retinal vascular caliber; LUSC cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg24562669 chr7:97807699 LMTK2 0.38 6.44 0.33 4.19e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs796364 0.901 rs13030683 chr2:201061535 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.67 0.3 3.15e-8 Schizophrenia; LUSC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.95e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16148416 chr1:33116824 RBBP4;ZBTB8OS -0.4 -6.07 -0.32 3.43e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2970818 0.831 rs12366731 chr12:4636095 A/G cg11146114 chr12:4671731 NA -0.6 -5.91 -0.31 8.39e-9 Phosphorus levels; LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg11645453 chr3:52864694 ITIH4 0.34 7.77 0.39 9.51e-14 Bipolar disorder; LUSC cis rs2290405 0.527 rs4690329 chr4:931385 T/A cg04824913 chr4:887549 GAK 0.72 9.71 0.47 8.26e-20 Systemic sclerosis; LUSC cis rs7605378 1.000 rs2346662 chr2:200679158 C/T cg17644776 chr2:200775616 C2orf69 0.36 5.75 0.3 2.04e-8 Osteoporosis; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg26516362 chr5:178986906 RUFY1 0.47 8.15 0.41 7.4e-15 Lung cancer; LUSC cis rs7267979 0.873 rs6115093 chr20:25210730 C/T cg08601574 chr20:25228251 PYGB 0.49 7.52 0.38 5.16e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8038465 0.615 rs6495075 chr15:73981005 A/G cg15420318 chr15:73925796 NPTN 0.57 9.59 0.46 2.1e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg00310523 chr12:86230176 RASSF9 0.52 9.81 0.47 3.84e-20 Major depressive disorder; LUSC cis rs1062746 1.000 rs1062746 chr16:87364650 A/G cg02258303 chr16:87377426 FBXO31 -0.54 -9.11 -0.45 7.91e-18 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC trans rs9747201 1.000 rs55638685 chr17:80107566 G/C cg07393940 chr7:158741817 NA -0.51 -8.09 -0.4 1.12e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs11992162 0.636 rs4841642 chr8:11798334 C/T cg27411982 chr8:10470053 RP1L1 0.42 6.33 0.33 7.72e-10 Monocyte count; LUSC cis rs600231 0.708 rs2957269 chr11:65243007 C/G cg21890820 chr11:65308645 LTBP3 0.49 7.16 0.36 5.14e-12 Bone mineral density; LUSC cis rs6500602 0.855 rs2304631 chr16:4475868 A/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 7.3 0.37 2.09e-12 Schizophrenia; LUSC cis rs7659604 0.540 rs11734075 chr4:122695685 C/T cg19748678 chr4:122722346 EXOSC9 -0.48 -7.0 -0.36 1.42e-11 Type 2 diabetes; LUSC cis rs208520 0.909 rs60604603 chr6:67022955 T/C cg07460842 chr6:66804631 NA 0.88 8.93 0.44 2.87e-17 Exhaled nitric oxide output; LUSC cis rs9388451 0.531 rs9321057 chr6:126156943 G/A cg05901451 chr6:126070800 HEY2 -0.66 -10.09 -0.48 4.59e-21 Brugada syndrome; LUSC trans rs6502050 0.835 rs12450189 chr17:80095128 A/C cg07393940 chr7:158741817 NA 0.37 6.78 0.35 5.58e-11 Life satisfaction; LUSC cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.88 -12.61 -0.57 4.44e-30 Chronic sinus infection; LUSC cis rs7100689 0.577 rs9421464 chr10:82043426 C/T cg00277334 chr10:82204260 NA -0.43 -6.15 -0.32 2.24e-9 Post bronchodilator FEV1; LUSC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg25566285 chr7:158114605 PTPRN2 0.31 5.87 0.31 1.05e-8 Calcium levels; LUSC cis rs1801251 0.963 rs7591176 chr2:233581803 C/A cg25237894 chr2:233734115 C2orf82 0.35 6.51 0.34 2.71e-10 Coronary artery disease; LUSC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg15744005 chr10:104629667 AS3MT -0.27 -5.75 -0.3 2.06e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg26408565 chr15:76604113 ETFA -0.52 -8.39 -0.42 1.38e-15 Blood metabolite levels; LUSC cis rs7918232 0.943 rs4747584 chr10:27373333 G/A cg14240646 chr10:27532245 ACBD5 -0.69 -7.97 -0.4 2.58e-14 Breast cancer; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg10659624 chr3:9885815 RPUSD3 0.44 6.12 0.32 2.69e-9 Mosquito bite size; LUSC cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg22676075 chr6:135203613 NA -0.74 -13.12 -0.58 5.27e-32 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9649465 0.561 rs600420 chr7:123408050 G/A cg03229431 chr7:123269106 ASB15 0.48 7.7 0.39 1.56e-13 Migraine; LUSC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.6 0.47 1.93e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg12564285 chr5:131593104 PDLIM4 0.34 6.27 0.32 1.09e-9 Blood metabolite levels; LUSC cis rs12618769 0.652 rs72823796 chr2:99227812 C/T cg10123293 chr2:99228465 UNC50 0.45 7.09 0.36 8.29e-12 Bipolar disorder; LUSC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg04362960 chr10:104952993 NT5C2 0.52 6.47 0.33 3.44e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg23583168 chr7:148888333 NA -0.9 -16.77 -0.68 3.14e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6681460 1.000 rs1536115 chr1:67121001 A/T cg02459107 chr1:67143332 SGIP1 0.47 9.0 0.44 1.75e-17 Presence of antiphospholipid antibodies; LUSC cis rs9303401 0.704 rs740605 chr17:56604811 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.52 7.96 0.4 2.69e-14 Cognitive test performance; LUSC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg05802129 chr4:122689817 NA -0.5 -8.47 -0.42 7.92e-16 Type 2 diabetes; LUSC cis rs6696846 0.765 rs61822568 chr1:205081166 C/G cg00857998 chr1:205179979 DSTYK 0.64 10.09 0.48 4.63e-21 Red blood cell count; LUSC cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -9.47 -0.46 5.41e-19 Chronic sinus infection; LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg06145435 chr7:1022769 CYP2W1 0.27 5.83 0.3 1.3e-8 Longevity;Endometriosis; LUSC cis rs2070488 0.775 rs762318 chr3:38516369 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.72 12.49 0.56 1.24e-29 Electrocardiographic conduction measures; LUSC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg11366901 chr6:160182831 ACAT2 0.93 13.06 0.58 8.98e-32 Age-related macular degeneration (geographic atrophy); LUSC trans rs61931739 0.500 rs11053140 chr12:34316122 T/C cg13010199 chr12:38710504 ALG10B 0.54 8.45 0.42 9.36e-16 Morning vs. evening chronotype; LUSC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg12463550 chr7:65579703 CRCP -0.56 -8.43 -0.42 1.02e-15 Aortic root size; LUSC trans rs3733585 0.699 rs6852441 chr4:9973744 C/T cg26043149 chr18:55253948 FECH -0.46 -7.05 -0.36 1.02e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3815700 0.925 rs395136 chr19:33106742 A/G cg02997394 chr19:33096574 ANKRD27 0.56 6.57 0.34 1.9e-10 Eosinophilic esophagitis; LUSC cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.14 -0.45 6.2e-18 Monocyte percentage of white cells; LUSC cis rs16867321 0.950 rs9677293 chr2:181499459 C/G cg23363182 chr2:181467187 NA -0.44 -5.74 -0.3 2.16e-8 Obesity; LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.94 0.48 1.4e-20 Bipolar disorder; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 6.81 0.35 4.45e-11 Renal function-related traits (BUN); LUSC cis rs6599077 1.000 rs6763643 chr3:40097991 A/G cg13683864 chr3:40499215 RPL14 -0.6 -6.55 -0.34 2.24e-10 Sleep-related phenotypes; LUSC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg21643547 chr1:205240462 TMCC2 -0.5 -9.3 -0.45 1.95e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs300703 0.872 rs12233077 chr2:120949 T/A cg21211680 chr2:198530 NA -0.77 -7.44 -0.38 8.86e-13 Blood protein levels; LUSC cis rs9311676 0.632 rs62259780 chr3:58428078 T/G cg13750441 chr3:58318267 PXK 0.35 6.77 0.35 5.67e-11 Systemic lupus erythematosus; LUSC cis rs921665 0.749 rs7563563 chr2:3201417 A/G cg16434511 chr2:3151078 NA 0.57 5.84 0.3 1.23e-8 World class endurance athleticism; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -13.2 -0.59 2.59e-32 Alzheimer's disease; LUSC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg21970626 chr13:21893289 NA -0.52 -9.64 -0.47 1.5e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs977987 0.843 rs11649638 chr16:75488285 G/A cg04384234 chr16:75411784 CFDP1 -0.45 -7.43 -0.38 9.37e-13 Dupuytren's disease; LUSC cis rs314370 0.904 rs314373 chr7:100456595 G/A cg10426581 chr7:100472382 SRRT 0.85 12.37 0.56 3.31e-29 Resting heart rate; LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs11992162 0.613 rs56094399 chr8:11797470 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.53 -0.34 2.42e-10 Monocyte count; LUSC cis rs9815354 0.638 rs76276404 chr3:41931770 A/G cg03022575 chr3:42003672 ULK4 0.82 8.55 0.42 4.49e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs7100689 0.555 rs1934146 chr10:82062121 C/A cg07663200 chr17:42030104 NA -0.37 -6.17 -0.32 1.99e-9 Post bronchodilator FEV1; LUSC cis rs7264396 0.635 rs6060692 chr20:34517925 A/T cg04508476 chr20:34239394 CPNE1;RBM12 0.61 8.93 0.44 2.98e-17 Total cholesterol levels; LUSC cis rs16854884 0.609 rs2885197 chr3:143636616 A/T cg06585982 chr3:143692056 C3orf58 -0.4 -6.38 -0.33 6.02e-10 Economic and political preferences (feminism/equality); LUSC cis rs9309473 1.000 rs13421462 chr2:73719875 A/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.54 -0.34 2.31e-10 Metabolite levels; LUSC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg14552801 chr7:65878734 NA -0.45 -6.51 -0.34 2.83e-10 Aortic root size; LUSC cis rs13089785 0.791 rs16834826 chr3:123584488 C/T cg19611163 chr3:123411211 MYLK -0.34 -5.89 -0.31 9.67e-9 Intelligence (multi-trait analysis); LUSC cis rs778371 1.000 rs778371 chr2:233743109 A/G cg08000102 chr2:233561755 GIGYF2 -0.72 -10.24 -0.49 1.43e-21 Schizophrenia; LUSC cis rs17092148 1.000 rs6060017 chr20:33313042 G/T cg16810054 chr20:33298113 TP53INP2 -0.38 -5.97 -0.31 6.19e-9 Neuroticism; LUSC cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg20821713 chr7:1055600 C7orf50 -0.53 -6.81 -0.35 4.66e-11 Bronchopulmonary dysplasia; LUSC cis rs34375054 0.672 rs10400509 chr12:125592173 T/C cg00522288 chr12:125625016 AACS -0.31 -5.9 -0.31 8.95e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs4363385 0.574 rs4845505 chr1:152960943 T/A cg00922841 chr1:152955080 SPRR1A -0.38 -6.47 -0.33 3.44e-10 Inflammatory skin disease; LUSC cis rs11864453 0.647 rs3764311 chr16:72125617 C/G cg16558253 chr16:72132732 DHX38 -0.37 -5.76 -0.3 1.86e-8 Fibrinogen levels; LUSC cis rs2115630 1.000 rs1030863 chr15:85282635 C/T cg11189052 chr15:85197271 WDR73 -0.45 -6.44 -0.33 4.19e-10 P wave terminal force; LUSC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg02380750 chr20:61661411 NA 0.34 5.9 0.31 8.82e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs858239 0.539 rs28716381 chr7:23189015 G/A cg23682824 chr7:23144976 KLHL7 0.4 5.71 0.3 2.52e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs4629180 0.586 rs290773 chr2:102125930 G/A cg01388757 chr2:102091195 RFX8 0.37 6.43 0.33 4.35e-10 Chronic rhinosinusitis with nasal polyps; LUSC cis rs12579753 1.000 rs7975863 chr12:82227288 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg24642439 chr20:33292090 TP53INP2 -0.49 -7.36 -0.37 1.47e-12 Glomerular filtration rate (creatinine); LUSC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.7 10.74 0.51 2.64e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6429082 0.523 rs704718 chr1:235666159 A/T cg26050004 chr1:235667680 B3GALNT2 0.81 14.14 0.61 6.96e-36 Adiposity; LUSC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg01416388 chr22:39784598 NA -0.43 -7.21 -0.37 3.82e-12 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg13683864 chr3:40499215 RPL14 -1.12 -20.02 -0.74 3.68e-59 Renal cell carcinoma; LUSC cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg01238044 chr22:24384105 GSTT1 -0.63 -10.11 -0.48 3.85e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2835872 0.965 rs2835855 chr21:39015754 T/A cg20424643 chr21:39039972 KCNJ6 0.43 6.5 0.34 2.94e-10 Electroencephalographic traits in alcoholism; LUSC cis rs7512552 0.839 rs1498308 chr1:150295131 G/T cg15654264 chr1:150340011 RPRD2 0.62 10.32 0.49 7.51e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg11764359 chr7:65958608 NA -0.69 -10.46 -0.5 2.43e-22 Aortic root size; LUSC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg01973587 chr1:228161476 NA 0.43 7.81 0.39 7.46e-14 Diastolic blood pressure; LUSC cis rs9329221 0.868 rs7831557 chr8:10280228 C/T cg27411982 chr8:10470053 RP1L1 -0.52 -7.89 -0.4 4.32e-14 Neuroticism; LUSC cis rs9303401 0.573 rs67378767 chr17:57194237 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.06 0.55 4.74e-28 Cognitive test performance; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg27462969 chr1:67896192 SERBP1 0.41 6.35 0.33 6.92e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs9467773 1.000 rs6456734 chr6:26566965 G/T cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.48e-42 Intelligence (multi-trait analysis); LUSC trans rs4295623 0.585 rs13259242 chr8:11593033 T/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.54 -0.42 4.78e-16 Morning vs. evening chronotype; LUSC cis rs6545883 0.811 rs778753 chr2:61780200 T/A cg15711740 chr2:61764176 XPO1 -0.44 -6.94 -0.36 2e-11 Tuberculosis; LUSC cis rs7945705 0.870 rs1109305 chr11:8955272 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.4 8.34 0.41 2.03e-15 Hemoglobin concentration; LUSC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.37 -6.27 -0.32 1.1e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2730245 0.527 rs2657362 chr7:158685095 A/G cg24397884 chr7:158709396 WDR60 0.8 8.96 0.44 2.34e-17 Height; LUSC cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC trans rs11696501 0.688 rs6124726 chr20:44307866 T/A cg03272292 chr12:48577362 C12orf68 0.5 5.98 0.31 5.74e-9 Brain structure; LUSC cis rs6570726 0.967 rs418662 chr6:145848832 A/C cg23711669 chr6:146136114 FBXO30 0.7 12.0 0.55 7.79e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.591 rs2736282 chr8:11225480 C/T cg21293242 chr8:11204541 TDH 0.31 5.93 0.31 7.54e-9 Retinal vascular caliber; LUSC cis rs4285028 0.747 rs7153 chr3:121383297 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.76 -0.57 1.17e-30 Multiple sclerosis; LUSC cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg21573476 chr21:45109991 RRP1B -0.38 -6.22 -0.32 1.47e-9 Mean corpuscular volume; LUSC cis rs9303401 0.659 rs34556735 chr17:56694447 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.66 0.57 2.74e-30 Cognitive test performance; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27489481 chr12:53399999 EIF4B -0.42 -6.19 -0.32 1.74e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6500395 1.000 rs3848321 chr16:48620780 A/T cg04672837 chr16:48644449 N4BP1 0.5 7.49 0.38 6.16e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.45 6.21 0.32 1.61e-9 Osteoporosis; LUSC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg18904891 chr8:8559673 CLDN23 0.56 7.69 0.39 1.68e-13 Obesity-related traits; LUSC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg25110423 chr6:41068646 NFYA;LOC221442 0.46 7.44 0.38 8.85e-13 Alzheimer's disease (late onset); LUSC trans rs11098499 0.954 rs10034623 chr4:120397829 G/A cg25214090 chr10:38739885 LOC399744 0.55 8.1 0.41 1.04e-14 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26492318 chr16:68344786 PRMT7;SLC7A6OS -0.41 -6.34 -0.33 7.55e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3126085 1.000 rs3120662 chr1:152302865 G/T cg26876637 chr1:152193138 HRNR -0.46 -5.81 -0.3 1.47e-8 Atopic dermatitis; LUSC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg01652190 chr22:50026171 C22orf34 0.34 7.17 0.37 4.81e-12 Monocyte count;Monocyte percentage of white cells; LUSC trans rs1908814 0.516 rs35391955 chr8:11796728 A/C cg15556689 chr8:8085844 FLJ10661 0.58 8.74 0.43 1.19e-16 Neuroticism; LUSC cis rs9325144 0.625 rs11534879 chr12:38968165 A/G cg26384229 chr12:38710491 ALG10B -0.65 -10.05 -0.48 6e-21 Morning vs. evening chronotype; LUSC cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg13010199 chr12:38710504 ALG10B 0.64 10.02 0.48 7.68e-21 Bladder cancer; LUSC cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg27279351 chr12:120934652 DYNLL1 0.59 7.93 0.4 3.43e-14 High light scatter reticulocyte count; LUSC trans rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05039488 chr6:79577232 IRAK1BP1 0.57 9.24 0.45 2.99e-18 Brugada syndrome; LUSC cis rs8141529 0.732 rs5997408 chr22:29207915 G/A cg15103426 chr22:29168792 CCDC117 0.58 7.88 0.4 4.78e-14 Lymphocyte counts; LUSC cis rs73198271 0.740 rs28521727 chr8:8647217 T/C cg15556689 chr8:8085844 FLJ10661 -0.47 -6.2 -0.32 1.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7212590 0.655 rs56198517 chr17:57976582 G/T cg10252138 chr17:58120427 NA -0.78 -7.19 -0.37 4.2e-12 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs6722750 0.783 rs4671550 chr2:64389314 T/A cg22352474 chr2:64371530 PELI1 0.64 10.08 0.48 4.86e-21 Neuroticism; LUSC cis rs763121 0.853 rs2179142 chr22:39037954 G/A cg14440974 chr22:39074834 NA -0.35 -5.8 -0.3 1.56e-8 Menopause (age at onset); LUSC cis rs4319547 0.695 rs4758645 chr12:122946487 G/A cg23029597 chr12:123009494 RSRC2 -0.62 -8.08 -0.4 1.17e-14 Body mass index; LUSC cis rs72960926 0.744 rs72964214 chr6:74864851 T/C cg03266952 chr6:74778945 NA -0.85 -7.25 -0.37 2.94e-12 Metabolite levels (MHPG); LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs11645898 0.765 rs112439757 chr16:72168337 C/T cg14768367 chr16:72042858 DHODH -0.52 -5.79 -0.3 1.61e-8 Blood protein levels; LUSC cis rs7177699 0.557 rs7176187 chr15:79121373 A/G cg00540400 chr15:79124168 NA 0.45 7.78 0.39 8.97e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24378470 chr17:9478950 WDR16;STX8 0.37 6.34 0.33 7.57e-10 Triglycerides; LUSC cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.8 8.21 0.41 5.03e-15 Initial pursuit acceleration; LUSC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg21724239 chr8:58056113 NA 0.62 7.02 0.36 1.21e-11 Developmental language disorder (linguistic errors); LUSC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg19920283 chr7:105172520 RINT1 0.6 6.38 0.33 5.9e-10 Bipolar disorder (body mass index interaction); LUSC cis rs11637445 0.640 rs4508380 chr15:68109049 G/A cg08079166 chr15:68083412 MAP2K5 0.35 7.21 0.37 3.84e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs3087591 0.960 rs1124918 chr17:29492423 A/G cg24425628 chr17:29625626 OMG;NF1 -0.51 -7.36 -0.37 1.48e-12 Hip circumference; LUSC cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg17261708 chr5:176794207 RGS14 0.34 5.95 0.31 6.9e-9 Hemoglobin concentration;Hematocrit; LUSC cis rs9435341 0.860 rs12406721 chr1:107563243 G/T cg09367891 chr1:107599246 PRMT6 0.5 7.07 0.36 9.12e-12 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs8010715 0.636 rs3825584 chr14:24587639 C/T cg23112188 chr14:24563095 PCK2 -0.33 -6.09 -0.32 3.17e-9 IgG glycosylation; LUSC cis rs950169 0.922 rs67804993 chr15:85104030 T/G cg12863693 chr15:85201151 NMB 0.35 7.1 0.36 7.35e-12 Schizophrenia; LUSC cis rs11650494 0.908 rs11656535 chr17:47425588 C/T cg08112188 chr17:47440006 ZNF652 1.19 9.8 0.47 4.43e-20 Prostate cancer; LUSC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg08847533 chr14:75593920 NEK9 0.85 15.72 0.65 4.5e-42 Height; LUSC cis rs7560272 0.538 rs2012574 chr2:73928366 G/C cg20560298 chr2:73613845 ALMS1 0.38 5.77 0.3 1.86e-8 Schizophrenia; LUSC cis rs3812049 0.826 rs34576922 chr5:127364103 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.68 -9.08 -0.44 9.73e-18 Lymphocyte counts;Red cell distribution width; LUSC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg05340658 chr4:99064831 C4orf37 0.65 10.77 0.51 2.08e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg01579765 chr21:45077557 HSF2BP -0.5 -10.31 -0.49 7.72e-22 Mean corpuscular volume; LUSC cis rs9687065 1.000 rs75777806 chr5:148403428 T/G cg23229984 chr5:148520753 ABLIM3 -0.38 -5.66 -0.3 3.24e-8 Diastolic blood pressure; LUSC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg06641503 chr3:48959341 ARIH2 -0.38 -5.87 -0.31 1.06e-8 Parkinson's disease; LUSC trans rs2197308 0.765 rs11182964 chr12:37935052 C/T cg06521331 chr12:34319734 NA -0.4 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype; LUSC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg03732007 chr1:2071316 PRKCZ 0.54 9.8 0.47 4.25e-20 Height; LUSC cis rs4242434 0.854 rs3064 chr8:22451688 C/G cg03733263 chr8:22462867 KIAA1967 -0.99 -17.23 -0.69 4.58e-48 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.21 -0.49 1.74e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.01 0.48 8.37e-21 Bladder cancer; LUSC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -11.64 -0.54 1.6e-26 Systemic lupus erythematosus; LUSC trans rs10411161 0.702 rs10402630 chr19:52384570 G/A cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs672059 0.967 rs514183 chr1:183163174 A/C ch.1.3577855R chr1:183094577 LAMC1 0.55 8.11 0.41 9.58e-15 Hypertriglyceridemia; LUSC cis rs7481584 0.624 rs412842 chr11:3047448 A/G cg08508325 chr11:3079039 CARS 0.37 8.24 0.41 3.91e-15 Calcium levels; LUSC cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.03 0.85 2.44e-93 Chronic sinus infection; LUSC cis rs11958404 0.932 rs61478293 chr5:157426299 G/A cg05962755 chr5:157440814 NA 0.5 6.04 0.31 4.18e-9 IgG glycosylation; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg17541922 chr11:86511813 PRSS23 -0.43 -6.11 -0.32 2.85e-9 Cognitive function;Information processing speed; LUSC cis rs1847202 0.826 rs1979884 chr3:72948515 T/C cg25664220 chr3:72788482 NA -0.41 -7.35 -0.37 1.49e-12 Motion sickness; LUSC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg20203395 chr5:56204925 C5orf35 -0.48 -7.2 -0.37 4.06e-12 Breast cancer;Breast cancer (early onset); LUSC cis rs4789693 0.518 rs6502108 chr17:80374899 A/C cg04308225 chr17:80449738 NA -0.37 -6.32 -0.33 8.22e-10 Glucocorticoid-induced osteonecrosis; LUSC cis rs10419226 0.555 rs3764627 chr19:18747696 C/T cg22001208 chr19:18782374 NA -0.35 -5.78 -0.3 1.72e-8 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg05025164 chr4:1340916 KIAA1530 0.65 9.83 0.47 3.46e-20 Longevity; LUSC cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg08213375 chr14:104286397 PPP1R13B 0.45 8.19 0.41 5.5e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs7107174 0.688 rs2063725 chr11:78133452 T/G cg02023728 chr11:77925099 USP35 0.41 6.29 0.33 9.67e-10 Testicular germ cell tumor; LUSC trans rs6952808 0.895 rs4513875 chr7:1928159 C/T cg04565464 chr8:145669602 NFKBIL2 0.39 6.48 0.33 3.33e-10 Bipolar disorder and schizophrenia; LUSC trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs12575480 0.637 rs56204981 chr11:2094852 T/C cg15541987 chr11:2077307 NA -0.44 -6.59 -0.34 1.76e-10 Pursuit maintenance gain; LUSC cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg21433313 chr16:3507492 NAT15 -0.4 -5.67 -0.3 3.07e-8 Body mass index (adult); LUSC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs12681287 0.604 rs7017716 chr8:87429001 A/C cg27223183 chr8:87520930 FAM82B -0.54 -7.46 -0.38 7.36e-13 Caudate activity during reward; LUSC cis rs1801251 1.000 rs1446308 chr2:233639309 T/C cg25237894 chr2:233734115 C2orf82 0.36 6.76 0.35 6.32e-11 Coronary artery disease; LUSC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.64 9.71 0.47 8.57e-20 Height; LUSC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.6 -0.38 3.03e-13 Developmental language disorder (linguistic errors); LUSC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg15556689 chr8:8085844 FLJ10661 -0.63 -9.85 -0.47 2.84e-20 Mood instability; LUSC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg16989086 chr20:62203971 PRIC285 0.46 6.4 0.33 5.3e-10 Glioblastoma; LUSC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg22868518 chr11:507468 RNH1 -0.57 -5.68 -0.3 2.93e-8 Body mass index; LUSC trans rs453301 0.571 rs2929453 chr8:9084341 A/G cg21775007 chr8:11205619 TDH -0.44 -6.29 -0.33 9.91e-10 Joint mobility (Beighton score); LUSC trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg03929089 chr4:120376271 NA -0.58 -7.09 -0.36 7.98e-12 Acute lymphoblastic leukemia (childhood); LUSC trans rs1973993 0.967 rs2181375 chr1:96940119 A/G cg10631902 chr5:14652156 NA 0.53 8.82 0.43 6.25e-17 Weight; LUSC cis rs6942756 0.806 rs2718096 chr7:128951000 A/G cg02491457 chr7:128862824 NA 0.48 7.17 0.37 4.82e-12 White matter hyperintensity burden; LUSC cis rs801193 0.901 rs4273746 chr7:66301111 C/T cg11764359 chr7:65958608 NA -0.59 -8.85 -0.44 5.05e-17 Aortic root size; LUSC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs6424115 0.800 rs2229583 chr1:24200983 C/T cg15997130 chr1:24165203 NA 0.53 8.68 0.43 1.71e-16 Immature fraction of reticulocytes; LUSC cis rs262150 1.000 rs262149 chr7:158778256 A/G cg04111992 chr7:158790115 NA 0.38 5.92 0.31 7.92e-9 Facial morphology (factor 20); LUSC cis rs9309473 0.632 rs11885217 chr2:73553208 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.74 -0.39 1.18e-13 Metabolite levels; LUSC trans rs4942242 1.000 rs4942242 chr13:44217064 A/G cg19169023 chr15:41853346 TYRO3 0.47 8.09 0.4 1.09e-14 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11169552 0.510 rs10876061 chr12:50968685 G/A cg12884762 chr12:50931848 DIP2B -0.32 -5.67 -0.3 3.11e-8 Colorectal cancer; LUSC cis rs748404 0.697 rs1814323 chr15:43563237 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.55 -8.6 -0.43 3.05e-16 Lung cancer; LUSC cis rs11023332 0.617 rs1451678 chr11:14781621 A/G cg05501817 chr11:14380813 RRAS2 -0.37 -5.71 -0.3 2.48e-8 Adiponectin levels;Vitamin D levels; LUSC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg20203395 chr5:56204925 C5orf35 -0.63 -9.41 -0.46 8.16e-19 Coronary artery disease; LUSC cis rs861020 1.000 rs642961 chr1:209989270 A/G cg05527609 chr1:210001259 C1orf107 0.94 12.38 0.56 3.09e-29 Orofacial clefts; LUSC cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg23796481 chr11:64053134 BAD;GPR137 0.52 8.14 0.41 8.04e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs9527 0.569 rs10883801 chr10:104677887 A/C cg08330031 chr10:104623503 C10orf32 0.32 5.69 0.3 2.76e-8 Arsenic metabolism; LUSC cis rs738322 0.967 rs133021 chr22:38573338 T/C cg25457927 chr22:38595422 NA -0.44 -9.11 -0.45 7.93e-18 Cutaneous nevi; LUSC cis rs5758659 0.904 rs5758653 chr22:42613485 G/T cg05082376 chr22:42548792 NA -0.39 -6.53 -0.34 2.5e-10 Cognitive function; LUSC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg03264133 chr6:25882463 NA -0.51 -8.49 -0.42 7.05e-16 Intelligence (multi-trait analysis); LUSC cis rs11051970 0.545 rs2728681 chr12:32582977 T/C cg02745156 chr12:32552066 NA 0.36 6.51 0.34 2.71e-10 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05195612 chr2:175869986 CHN1 -0.47 -6.16 -0.32 2.13e-9 Bipolar disorder and schizophrenia; LUSC cis rs7072216 0.763 rs942803 chr10:100168631 G/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.69 -0.43 1.68e-16 Metabolite levels; LUSC cis rs9283706 0.641 rs1990894 chr5:66331685 C/T cg11590213 chr5:66331682 MAST4 0.45 7.47 0.38 6.91e-13 Coronary artery disease; LUSC cis rs4601821 1.000 rs4601821 chr11:113250346 A/G cg14159747 chr11:113255604 NA 0.26 6.12 0.32 2.69e-9 Alcoholic chronic pancreatitis; LUSC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg16479474 chr6:28041457 NA 0.32 5.65 0.3 3.45e-8 Parkinson's disease; LUSC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg00814883 chr7:100076585 TSC22D4 -0.75 -9.41 -0.46 8.54e-19 Platelet count; LUSC trans rs9929218 1.000 rs13339591 chr16:68809273 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.72 -0.54 8.62e-27 Colorectal cancer; LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg21782813 chr7:2030301 MAD1L1 0.58 10.34 0.49 6.26e-22 Bipolar disorder and schizophrenia; LUSC trans rs57221529 0.655 rs11948381 chr5:568413 A/T cg11887960 chr12:57824829 NA 0.47 6.54 0.34 2.29e-10 Lung disease severity in cystic fibrosis; LUSC cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg25208724 chr1:156163844 SLC25A44 1.08 25.08 0.81 8.45e-79 Testicular germ cell tumor; LUSC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg16262614 chr3:133464971 TF -0.44 -7.88 -0.4 4.55e-14 Iron status biomarkers (transferrin levels); LUSC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.73 -0.35 7.23e-11 Mean platelet volume; LUSC cis rs6426558 0.537 rs6685823 chr1:227270835 A/G cg10327440 chr1:227177885 CDC42BPA 0.55 7.51 0.38 5.46e-13 Neutrophil percentage of white cells; LUSC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg10523679 chr1:76189770 ACADM 0.88 12.76 0.57 1.19e-30 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9814567 0.896 rs4245907 chr3:134347876 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.97 -0.61 2.98e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg21951975 chr1:209979733 IRF6 0.57 8.52 0.42 5.74e-16 Cleft lip with or without cleft palate; LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.18 -0.32 1.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs9522267 0.535 rs7339347 chr13:112237920 C/T cg10483660 chr13:112241077 NA -0.32 -5.9 -0.31 9.07e-9 Hepatitis; LUSC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg27165867 chr14:105738592 BRF1 -0.57 -8.61 -0.43 2.87e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs2357013 0.725 rs1858211 chr2:53165520 G/C cg07782112 chr2:53107842 NA -0.39 -6.16 -0.32 2.04e-9 Hemostatic factors and hematological phenotypes; LUSC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs6121246 0.821 rs7265413 chr20:30317923 G/A cg18721089 chr20:30220636 NA -0.34 -5.89 -0.31 9.62e-9 Mean corpuscular hemoglobin; LUSC cis rs3862030 0.720 rs2025713 chr10:104230156 A/G cg05855489 chr10:104503620 C10orf26 0.49 7.36 0.37 1.48e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs2629751 0.512 rs2583271 chr12:104440855 C/T cg14987745 chr12:104360022 TDG -0.71 -8.36 -0.42 1.73e-15 Hepatitis C induced liver fibrosis; LUSC cis rs17401966 0.838 rs4846207 chr1:10313811 T/C cg19773385 chr1:10388646 KIF1B -0.51 -8.81 -0.43 6.93e-17 Hepatocellular carcinoma; LUSC cis rs4561483 0.801 rs33643 chr16:11986149 A/G cg08843971 chr16:11963173 GSPT1 -0.46 -6.89 -0.35 2.75e-11 Testicular germ cell tumor; LUSC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg19468946 chr17:37922297 IKZF3 0.47 7.45 0.38 8.3e-13 Self-reported allergy; LUSC cis rs12995491 0.933 rs12995212 chr2:88527184 C/T cg18302933 chr2:88491318 NA -0.35 -6.5 -0.34 2.85e-10 Response to metformin (IC50); LUSC cis rs754466 0.580 rs10762763 chr10:79560803 C/G cg17075019 chr10:79541650 NA -0.69 -10.77 -0.51 2.01e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6867032 0.874 rs4975786 chr5:2004724 T/C cg26168224 chr5:2018326 NA -0.72 -12.42 -0.56 2.14e-29 Gut microbiome composition (winter); LUSC cis rs10761482 0.861 rs2893830 chr10:62099945 C/T cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.73 10.32 0.49 7.36e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1008375 0.966 rs12503540 chr4:17698781 C/G cg16339924 chr4:17578868 LAP3 -0.47 -6.88 -0.35 3.01e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.48 5.9 0.31 9.16e-9 Renal function-related traits (BUN); LUSC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg00033643 chr7:134001901 SLC35B4 0.46 7.2 0.37 4.12e-12 Mean platelet volume; LUSC cis rs611744 0.625 rs11991891 chr8:109294858 G/A cg18478394 chr8:109455254 TTC35 0.44 6.88 0.35 3.02e-11 Dupuytren's disease; LUSC cis rs6495122 0.501 rs12101482 chr15:75344784 A/T cg09165964 chr15:75287851 SCAMP5 -0.46 -6.67 -0.34 1.06e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs12220238 1.000 rs10824099 chr10:75943625 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.85 0.35 3.57e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -9.61 -0.47 1.88e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg20573242 chr4:122745356 CCNA2 0.44 6.78 0.35 5.48e-11 Type 2 diabetes; LUSC cis rs308403 0.509 rs6811183 chr4:123671551 T/G cg10495464 chr4:123653540 BBS12;LOC729338 0.94 17.03 0.68 3.01e-47 Blood protein levels; LUSC cis rs870825 0.616 rs6810600 chr4:185616814 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.5 0.59 1.86e-33 Blood protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03909902 chr12:108154529 PRDM4 0.37 5.97 0.31 6.08e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs367615 0.552 rs2963022 chr5:108727185 A/G cg17395555 chr5:108820864 NA -0.46 -8.0 -0.4 2.07e-14 Colorectal cancer (SNP x SNP interaction); LUSC cis rs4654899 1.000 rs7522722 chr1:21481840 G/A cg01072550 chr1:21505969 NA -0.55 -8.5 -0.42 6.28e-16 Superior frontal gyrus grey matter volume; LUSC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC trans rs9951602 0.512 rs1903722 chr18:76646539 G/A cg02800362 chr5:177631904 HNRNPAB 0.85 13.0 0.58 1.46e-31 Obesity-related traits; LUSC cis rs9420 0.528 rs11229075 chr11:57391023 A/C cg23127183 chr11:57508653 C11orf31 -0.48 -6.69 -0.34 9.42e-11 Schizophrenia; LUSC cis rs240764 0.658 rs13196803 chr6:101188052 A/T cg09795085 chr6:101329169 ASCC3 -0.45 -6.56 -0.34 2.03e-10 Neuroticism; LUSC trans rs11098499 0.954 rs7681544 chr4:120411255 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.06 0.4 1.36e-14 Corneal astigmatism; LUSC cis rs9399401 0.677 rs6925979 chr6:142651052 G/A cg03128060 chr6:142623767 GPR126 0.58 9.37 0.46 1.12e-18 Chronic obstructive pulmonary disease; LUSC trans rs72674100 1.000 rs2865757 chr4:97992597 C/T cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2290416 0.892 rs3793372 chr8:144664233 A/C cg08017634 chr8:144659831 NAPRT1 0.68 5.94 0.31 7.24e-9 Attention deficit hyperactivity disorder; LUSC cis rs9457247 0.602 rs4710175 chr6:167467800 A/G cg06454157 chr6:167490870 NA -0.3 -6.89 -0.35 2.83e-11 Crohn's disease; LUSC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg14092988 chr3:52407081 DNAH1 0.43 8.13 0.41 8.27e-15 Bipolar disorder; LUSC cis rs2274273 0.682 rs7141975 chr14:55542216 G/C cg04306507 chr14:55594613 LGALS3 0.49 10.14 0.49 3.09e-21 Protein biomarker; LUSC cis rs4237845 0.537 rs10747787 chr12:58260657 A/G cg02175503 chr12:58329896 NA 0.49 7.18 0.37 4.51e-12 Intelligence (multi-trait analysis); LUSC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg12463550 chr7:65579703 CRCP 0.54 8.13 0.41 8.63e-15 Aortic root size; LUSC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg13206674 chr6:150067644 NUP43 0.61 9.85 0.47 2.82e-20 Lung cancer; LUSC trans rs10432489 0.708 rs3922471 chr2:181771937 T/C cg04744134 chr19:8408128 KANK3 0.83 6.27 0.32 1.13e-9 QT interval; LUSC cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg27129171 chr3:47204927 SETD2 0.7 11.72 0.54 8.25e-27 Colorectal cancer; LUSC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg25554036 chr4:6271136 WFS1 0.61 12.65 0.57 3.12e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.24e-15 Chronic sinus infection; LUSC cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg08807101 chr21:30365312 RNF160 0.79 14.93 0.63 5.62e-39 Dental caries; LUSC cis rs2075671 0.903 rs10953300 chr7:100263784 C/G cg20848291 chr7:100343083 ZAN -0.65 -8.69 -0.43 1.6e-16 Other erythrocyte phenotypes; LUSC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg24562669 chr7:97807699 LMTK2 0.36 6.31 0.33 8.71e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs11105298 0.891 rs10858852 chr12:89833338 T/C cg00757033 chr12:89920650 WDR51B 0.59 10.15 0.49 2.74e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7119 0.717 rs35268067 chr15:77753688 C/G cg05673287 chr15:77411982 SGK269 -0.44 -6.97 -0.36 1.7e-11 Type 2 diabetes; LUSC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg23283495 chr1:209979779 IRF6 0.72 9.14 0.45 6.03e-18 Cleft lip with or without cleft palate; LUSC cis rs9747201 0.963 rs4789729 chr17:80146089 G/A cg17462356 chr17:80056334 FASN -0.45 -6.18 -0.32 1.86e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11229555 0.645 rs12801475 chr11:58189034 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9389248 0.690 rs6939543 chr6:135255143 A/G cg24558204 chr6:135376177 HBS1L -0.6 -8.7 -0.43 1.53e-16 High light scatter reticulocyte percentage of red cells; LUSC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.81 0.54 3.94e-27 Prudent dietary pattern; LUSC cis rs829883 0.659 rs11109522 chr12:98930964 C/T cg25150519 chr12:98850993 NA -0.63 -8.71 -0.43 1.47e-16 Colorectal adenoma (advanced); LUSC cis rs807669 0.835 rs1780639 chr22:19174603 T/C cg02655711 chr22:19163373 SLC25A1 0.91 17.84 0.7 1.74e-50 Metabolite levels; LUSC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg13319975 chr6:146136371 FBXO30 0.52 7.75 0.39 1.12e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg04727924 chr7:799746 HEATR2 -0.57 -5.91 -0.31 8.66e-9 Cerebrospinal P-tau181p levels; LUSC cis rs10848704 0.525 rs4765709 chr12:2883637 C/T cg19995117 chr12:2880862 NA 0.47 8.55 0.42 4.5e-16 Quantitative traits; LUSC cis rs6500395 1.000 rs1486411 chr16:48587083 T/C cg04672837 chr16:48644449 N4BP1 0.43 6.36 0.33 6.48e-10 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05608588 chr7:98476815 TRRAP -0.5 -6.1 -0.32 2.9e-9 Bipolar disorder and schizophrenia; LUSC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg07959070 chr22:50026188 C22orf34 -0.36 -7.39 -0.37 1.18e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg12165864 chr7:66369176 NA -0.54 -7.36 -0.37 1.48e-12 Corneal structure; LUSC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.8 11.29 0.53 2.88e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs5769765 1.000 rs4824106 chr22:50267822 T/C cg26441486 chr22:50317300 CRELD2 -0.55 -8.31 -0.41 2.4e-15 Schizophrenia; LUSC trans rs3857536 0.740 rs7751095 chr6:66891318 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg12564285 chr5:131593104 PDLIM4 0.35 6.42 0.33 4.59e-10 Blood metabolite levels; LUSC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg18904891 chr8:8559673 CLDN23 -0.42 -6.32 -0.33 8.28e-10 Mood instability; LUSC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg22467129 chr15:76604101 ETFA -0.46 -7.24 -0.37 3.21e-12 Blood metabolite levels; LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 14.07 0.61 1.24e-35 Platelet count; LUSC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg11764359 chr7:65958608 NA -0.71 -11.04 -0.52 2.31e-24 Aortic root size; LUSC cis rs11971779 0.878 rs4732378 chr7:139120395 C/T cg07862535 chr7:139043722 LUC7L2 0.73 8.29 0.41 2.73e-15 Diisocyanate-induced asthma; LUSC cis rs7011049 1.000 rs72640849 chr8:53836430 A/T cg26025543 chr8:53854495 NA 0.5 6.01 0.31 4.83e-9 Systolic blood pressure; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.2 -0.37 4.1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11098499 0.562 rs13101722 chr4:120555975 C/A cg25214090 chr10:38739885 LOC399744 -0.4 -6.42 -0.33 4.56e-10 Corneal astigmatism; LUSC cis rs1018697 1.000 rs6584525 chr10:104551981 G/A cg04362960 chr10:104952993 NT5C2 0.47 6.48 0.33 3.29e-10 Colorectal adenoma (advanced); LUSC cis rs796364 0.806 rs76112266 chr2:201087157 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.74 -8.22 -0.41 4.63e-15 Schizophrenia; LUSC cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg22455342 chr2:225449267 CUL3 0.72 9.46 0.46 5.66e-19 IgE levels in asthmatics (D.p. specific); LUSC cis rs394563 0.591 rs237016 chr6:149744859 T/C cg11245181 chr6:149772854 ZC3H12D -0.29 -6.27 -0.32 1.1e-9 Dupuytren's disease; LUSC cis rs611744 0.647 rs2848620 chr8:109249551 G/T cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 7.89e-10 Dupuytren's disease; LUSC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.88 0.31 9.8e-9 Schizophrenia; LUSC cis rs2486288 0.656 rs11632651 chr15:45550838 C/T cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.02e-14 Glomerular filtration rate; LUSC cis rs714027 1.000 rs5997579 chr22:30537526 A/G cg11564601 chr22:30592435 NA -0.38 -7.17 -0.37 4.9e-12 Lymphocyte counts; LUSC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.88 0.4 4.75e-14 Major depressive disorder; LUSC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg02079420 chr8:82753780 SNX16 0.39 6.87 0.35 3.14e-11 Diastolic blood pressure; LUSC cis rs977987 0.966 rs6564261 chr16:75492242 C/T cg04384234 chr16:75411784 CFDP1 -0.46 -7.7 -0.39 1.6e-13 Dupuytren's disease; LUSC cis rs7681440 0.606 rs2619342 chr4:90744170 A/T cg06632027 chr4:90757378 SNCA -0.36 -5.7 -0.3 2.57e-8 Dementia with Lewy bodies; LUSC cis rs2901656 0.691 rs10798005 chr1:172382965 C/T cg03748243 chr1:172413542 C1orf105;PIGC -0.37 -7.48 -0.38 6.5e-13 Red cell distribution width;Platelet distribution width; LUSC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg02896835 chr1:92012615 NA -0.68 -12.38 -0.56 3.13e-29 Breast cancer; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg04944784 chr2:26401820 FAM59B -0.74 -10.91 -0.51 6.48e-24 Gut microbiome composition (summer); LUSC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg05855489 chr10:104503620 C10orf26 0.65 9.66 0.47 1.21e-19 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6142102 0.923 rs3787230 chr20:32640272 A/G cg08999081 chr20:33150536 PIGU 0.34 5.83 0.3 1.3e-8 Skin pigmentation; LUSC trans rs208520 0.690 rs12189780 chr6:66759619 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.07 16.68 0.67 7.3e-46 Exhaled nitric oxide output; LUSC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg11344533 chr11:111475393 SIK2 -0.5 -6.95 -0.36 1.88e-11 Primary sclerosing cholangitis; LUSC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.73 -13.09 -0.58 7.06e-32 Personality dimensions; LUSC cis rs546131 0.820 rs744841 chr11:34857667 G/A cg11058730 chr11:34937778 PDHX;APIP 0.47 6.55 0.34 2.2e-10 Lung disease severity in cystic fibrosis; LUSC cis rs4654899 0.727 rs11805169 chr1:21156862 A/T cg01072550 chr1:21505969 NA 0.49 7.48 0.38 6.8e-13 Superior frontal gyrus grey matter volume; LUSC cis rs9486715 0.867 rs2223238 chr6:96871855 G/A cg06623918 chr6:96969491 KIAA0776 0.93 17.58 0.69 1.94e-49 Headache; LUSC cis rs7818688 0.697 rs11778553 chr8:95978260 C/T cg16049864 chr8:95962084 TP53INP1 0.47 5.71 0.3 2.53e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; LUSC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg05425664 chr17:57184151 TRIM37 0.54 8.01 0.4 1.87e-14 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13257044 chr4:1714050 SLBP -0.42 -6.29 -0.33 9.83e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg15445000 chr17:37608096 MED1 -0.4 -6.79 -0.35 5.16e-11 Glomerular filtration rate (creatinine); LUSC trans rs561341 0.941 rs550213 chr17:30317518 C/G cg20587970 chr11:113659929 NA -1.16 -15.97 -0.66 4.56e-43 Hip circumference adjusted for BMI; LUSC cis rs1801251 0.656 rs10211596 chr2:233699415 C/T cg08000102 chr2:233561755 GIGYF2 -0.61 -10.24 -0.49 1.38e-21 Coronary artery disease; LUSC cis rs9467773 0.935 rs11752946 chr6:26560364 C/A cg09904177 chr6:26538194 HMGN4 0.72 12.71 0.57 1.82e-30 Intelligence (multi-trait analysis); LUSC cis rs12618769 0.597 rs4851131 chr2:99036802 A/C cg10123293 chr2:99228465 UNC50 0.46 7.69 0.39 1.66e-13 Bipolar disorder; LUSC cis rs9303401 0.573 rs34097494 chr17:57171917 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.13 0.55 2.54e-28 Cognitive test performance; LUSC cis rs9790314 0.586 rs11713185 chr3:161111357 C/G cg03342759 chr3:160939853 NMD3 -0.44 -6.84 -0.35 3.83e-11 Morning vs. evening chronotype; LUSC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg03929089 chr4:120376271 NA 0.92 15.71 0.65 5.07e-42 Height; LUSC cis rs17604090 0.877 rs68169519 chr7:29685158 A/G cg19413766 chr7:29689036 LOC646762 -0.58 -6.82 -0.35 4.19e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs977987 0.806 rs4888389 chr16:75395228 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.95 -0.36 1.94e-11 Dupuytren's disease; LUSC cis rs295140 0.605 rs10931893 chr2:201114652 A/G cg23649088 chr2:200775458 C2orf69 -0.4 -6.01 -0.31 4.76e-9 QT interval; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg14159672 chr1:205819179 PM20D1 0.85 15.08 0.64 1.49e-39 Menarche (age at onset); LUSC cis rs3862435 0.706 rs2301828 chr15:90992654 G/T cg22089800 chr15:90895588 ZNF774 0.57 5.97 0.31 5.95e-9 Response to exercise (triglyceride level interaction); LUSC cis rs4595586 0.525 rs35089392 chr12:39414547 T/G cg26384229 chr12:38710491 ALG10B 0.54 7.54 0.38 4.39e-13 Morning vs. evening chronotype; LUSC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg19717773 chr7:2847554 GNA12 -0.34 -5.85 -0.31 1.15e-8 Height; LUSC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg04369109 chr6:150039330 LATS1 -0.54 -8.03 -0.4 1.7e-14 Lung cancer; LUSC cis rs3760982 0.585 rs67648499 chr19:44294055 G/A cg11993925 chr19:44307056 LYPD5 0.35 7.65 0.39 2.11e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 7.02 0.36 1.24e-11 Hip circumference adjusted for BMI; LUSC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg18252515 chr7:66147081 NA 1.23 14.01 0.61 2.04e-35 Diabetic kidney disease; LUSC cis rs34779708 0.931 rs35997236 chr10:35376690 C/T cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs73036520 0.560 rs346750 chr19:45737218 G/T cg01416317 chr19:45737208 EXOC3L2 -0.47 -8.44 -0.42 9.82e-16 Monocyte percentage of white cells; LUSC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg05347473 chr6:146136440 FBXO30 0.52 8.98 0.44 2.02e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs3862030 0.720 rs1056744 chr10:104236687 A/G cg22532475 chr10:104410764 TRIM8 0.24 5.76 0.3 1.93e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs68170813 0.559 rs74745121 chr7:106958037 T/C cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC cis rs113835537 0.529 rs17147644 chr11:66256660 C/T cg24851651 chr11:66362959 CCS 0.54 8.03 0.4 1.71e-14 Airway imaging phenotypes; LUSC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg18404041 chr3:52824283 ITIH1 -0.36 -6.19 -0.32 1.79e-9 Electroencephalogram traits; LUSC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06787431 chr3:185827293 ETV5 0.47 8.05 0.4 1.48e-14 Triglycerides; LUSC cis rs7647973 0.626 rs11130217 chr3:49737323 A/G cg13072238 chr3:49761600 GMPPB -0.65 -8.27 -0.41 3.11e-15 Menarche (age at onset); LUSC cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg13319975 chr6:146136371 FBXO30 0.48 7.28 0.37 2.35e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs939658 0.728 rs8031638 chr15:79422726 C/T cg17916960 chr15:79447300 NA -0.5 -9.52 -0.46 3.7e-19 Refractive error; LUSC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.66 6.38 0.33 5.83e-10 Cerebrospinal P-tau181p levels; LUSC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11644478 chr21:40555479 PSMG1 -0.65 -10.18 -0.49 2.18e-21 Menarche (age at onset); LUSC cis rs934734 0.563 rs11684155 chr2:65581300 C/T cg08085232 chr2:65598271 SPRED2 -0.43 -6.71 -0.34 8.27e-11 Rheumatoid arthritis; LUSC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg10729496 chr3:10149963 C3orf24 0.54 7.24 0.37 3.16e-12 Alzheimer's disease; LUSC cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.75 -0.43 1.11e-16 Uric acid levels; LUSC cis rs8141529 0.748 rs132531 chr22:29297365 C/T cg02153584 chr22:29168773 CCDC117 -0.58 -8.6 -0.43 3.11e-16 Lymphocyte counts; LUSC cis rs35146811 0.695 rs1727132 chr7:99812297 T/C cg19116668 chr7:99932089 PMS2L1 0.35 6.12 0.32 2.68e-9 Coronary artery disease; LUSC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg11764359 chr7:65958608 NA -0.62 -9.38 -0.46 1.03e-18 Aortic root size; LUSC cis rs16866061 0.515 rs13020268 chr2:225437923 C/T cg12698349 chr2:225449008 CUL3 1.01 20.85 0.75 1.94e-62 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs950169 0.541 rs10795 chr15:85177297 G/A cg11189052 chr15:85197271 WDR73 0.5 6.39 0.33 5.56e-10 Schizophrenia; LUSC trans rs4713118 0.527 rs4713151 chr6:28136356 G/A cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Parkinson's disease; LUSC trans rs7786808 0.712 rs12671981 chr7:158202971 G/A cg02030672 chr11:45687055 CHST1 0.47 7.35 0.37 1.52e-12 Obesity-related traits; LUSC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25816013 chr10:124913724 BUB3 -0.48 -7.14 -0.36 5.76e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4631830 0.695 rs11004584 chr10:51500088 G/T cg10326726 chr10:51549505 MSMB -0.36 -6.19 -0.32 1.8e-9 Prostate-specific antigen levels; LUSC cis rs7917772 0.582 rs11191352 chr10:104372244 A/G cg22532475 chr10:104410764 TRIM8 -0.25 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11122272 0.735 rs2749706 chr1:231527170 C/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC trans rs7507204 0.767 rs12982509 chr19:3412057 C/T cg08382705 chr11:45687319 CHST1 0.53 7.27 0.37 2.54e-12 Height; LUSC cis rs2074585 0.806 rs2657949 chr15:90950790 G/A cg03599575 chr15:90893182 GABARAPL3 0.34 5.89 0.31 9.29e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.54 -0.42 4.74e-16 Personality dimensions; LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.2 0.37 3.98e-12 Bipolar disorder; LUSC cis rs28735056 0.933 rs499260 chr18:77589689 G/A cg20368463 chr18:77673604 PQLC1 -0.54 -7.75 -0.39 1.15e-13 Schizophrenia; LUSC cis rs1395 0.778 rs4665960 chr2:27467598 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.26 0.37 2.68e-12 Blood metabolite levels; LUSC cis rs4595586 0.545 rs1156707 chr12:39372451 G/T cg26384229 chr12:38710491 ALG10B 0.49 6.99 0.36 1.51e-11 Morning vs. evening chronotype; LUSC cis rs4132509 1.000 rs10927051 chr1:243805936 G/C cg21452805 chr1:244014465 NA 0.5 5.94 0.31 6.99e-9 RR interval (heart rate); LUSC trans rs2832077 0.883 rs35672956 chr21:30189042 T/C cg14791747 chr16:20752902 THUMPD1 0.73 9.55 0.46 2.84e-19 Cognitive test performance; LUSC cis rs1003719 0.715 rs2835653 chr21:38558636 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.41 -0.49 3.71e-22 Eye color traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00762468 chr16:103568 POLR3K;SNRNP25 -0.48 -6.31 -0.33 8.65e-10 Bipolar disorder and schizophrenia; LUSC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.16 0.36 5.14e-12 Hip circumference adjusted for BMI; LUSC cis rs3096299 0.869 rs748941 chr16:89440754 T/A cg02187348 chr16:89574699 SPG7 0.47 7.0 0.36 1.39e-11 Multiple myeloma (IgH translocation); LUSC trans rs6502050 0.835 rs35857672 chr17:80078303 G/A cg07393940 chr7:158741817 NA -0.37 -6.76 -0.35 6.27e-11 Life satisfaction; LUSC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 8.33 0.41 2.14e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2932538 0.922 rs6681371 chr1:113101168 A/C cg22162597 chr1:113214053 CAPZA1 0.6 8.3 0.41 2.64e-15 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg11494091 chr17:61959527 GH2 0.64 13.4 0.59 4.72e-33 Prudent dietary pattern; LUSC cis rs1953600 0.870 rs2788296 chr10:81937889 G/A cg00277334 chr10:82204260 NA 0.45 7.12 0.36 6.85e-12 Sarcoidosis; LUSC cis rs17001868 0.614 rs61467436 chr22:40736713 T/C cg07138101 chr22:40742427 ADSL 0.63 7.6 0.38 3.04e-13 Mammographic density (dense area); LUSC cis rs2486288 0.656 rs2413772 chr15:45549862 G/A cg09092052 chr15:45571596 NA 0.45 6.31 0.33 8.87e-10 Glomerular filtration rate; LUSC cis rs968567 0.705 rs174573 chr11:61600327 G/A cg19610905 chr11:61596333 FADS2 -0.43 -5.88 -0.31 9.69e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs9399135 0.967 rs1041480 chr6:135373076 G/T cg24558204 chr6:135376177 HBS1L 0.58 9.03 0.44 1.38e-17 Red blood cell count; LUSC cis rs17401966 0.800 rs12122029 chr1:10339822 G/A cg19773385 chr1:10388646 KIF1B -0.5 -8.71 -0.43 1.4e-16 Hepatocellular carcinoma; LUSC cis rs8060686 0.516 rs4640173 chr16:68163602 C/A cg09835421 chr16:68378352 PRMT7 -0.48 -5.95 -0.31 6.7e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg16405210 chr4:1374714 KIAA1530 -0.57 -8.8 -0.43 7.35e-17 Obesity-related traits; LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg25767906 chr1:53392781 SCP2 0.48 8.69 0.43 1.67e-16 Monocyte count; LUSC cis rs1801251 1.000 rs283476 chr2:233650168 A/G cg08000102 chr2:233561755 GIGYF2 0.76 11.82 0.54 3.75e-27 Coronary artery disease; LUSC cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.71 8.62 0.43 2.75e-16 Chronic sinus infection; LUSC cis rs6700896 0.500 rs11208690 chr1:66092349 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.17 0.32 2.02e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg25566285 chr7:158114605 PTPRN2 0.32 5.89 0.31 9.5e-9 Calcium levels; LUSC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg27494647 chr7:150038898 RARRES2 0.51 7.42 0.38 9.68e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs13217239 0.646 rs2142685 chr6:27054497 C/T cg05738196 chr6:26577821 NA -0.54 -8.48 -0.42 7.42e-16 Schizophrenia; LUSC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg06877462 chr1:205807181 PM20D1 0.39 7.35 0.37 1.56e-12 Menarche (age at onset); LUSC cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.46 6.74 0.35 6.79e-11 Systemic lupus erythematosus; LUSC cis rs2404602 0.692 rs7163397 chr15:76940315 A/G cg22467129 chr15:76604101 ETFA -0.42 -6.64 -0.34 1.28e-10 Blood metabolite levels; LUSC cis rs4722404 0.739 rs10951044 chr7:3141147 C/T cg19214707 chr7:3157722 NA -0.37 -6.88 -0.35 3.01e-11 Atopic dermatitis; LUSC cis rs9362426 1.000 rs9450662 chr6:88088593 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.38 6.16 0.32 2.06e-9 Depressive episodes in bipolar disorder; LUSC cis rs9372253 0.843 rs28721292 chr6:110719631 T/C cg01119278 chr6:110721349 DDO -0.49 -8.85 -0.44 5.04e-17 Platelet distribution width; LUSC cis rs2071303 0.836 rs198835 chr6:26113994 T/G cg17691542 chr6:26056736 HIST1H1C 0.41 6.06 0.31 3.71e-9 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg06873352 chr17:61820015 STRADA 0.72 12.97 0.58 1.89e-31 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg25072359 chr17:41440525 NA 0.65 9.37 0.46 1.09e-18 Menopause (age at onset); LUSC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.42 0.42 1.16e-15 Tonsillectomy; LUSC cis rs7605827 0.897 rs6431713 chr2:15691382 C/T cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.32e-17 Educational attainment (years of education); LUSC cis rs290268 0.585 rs290992 chr9:93561309 C/T cg02608019 chr9:93564028 SYK -0.37 -6.15 -0.32 2.26e-9 Platelet count; LUSC cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7202877 0.561 rs2865532 chr16:75350975 A/G cg04384234 chr16:75411784 CFDP1 -0.61 -8.27 -0.41 3.15e-15 Type 2 diabetes;Type 1 diabetes; LUSC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs80130819 0.515 rs1793956 chr12:48392914 C/G cg24011408 chr12:48396354 COL2A1 0.59 7.8 0.39 7.82e-14 Prostate cancer; LUSC trans rs225245 0.817 rs225299 chr17:33922742 T/C cg19694781 chr19:47549865 TMEM160 -0.42 -6.59 -0.34 1.69e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg07148914 chr20:33460835 GGT7 0.54 8.23 0.41 4.3e-15 Height; LUSC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 9.64 0.47 1.43e-19 Eosinophil percentage of white cells; LUSC cis rs3733585 0.648 rs13125029 chr4:9982029 A/G cg00071950 chr4:10020882 SLC2A9 0.52 8.69 0.43 1.68e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7945718 0.839 rs11022512 chr11:12835952 G/A cg25843174 chr11:12811716 TEAD1 0.3 6.9 0.35 2.61e-11 Educational attainment (years of education); LUSC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg03517284 chr6:25882590 NA 0.63 11.01 0.52 2.81e-24 Blood metabolite levels; LUSC cis rs6840360 0.615 rs1962910 chr4:152479392 T/A cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.59e-10 Intelligence (multi-trait analysis); LUSC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg05425664 chr17:57184151 TRIM37 -0.53 -7.99 -0.4 2.25e-14 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg03060546 chr3:49711283 APEH 0.47 6.29 0.33 1.02e-9 Menarche (age at onset); LUSC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg08132940 chr7:1081526 C7orf50 -0.47 -6.13 -0.32 2.46e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs72700829 0.531 rs12070288 chr1:151009984 C/G cg11822372 chr1:151115635 SEMA6C -0.76 -6.94 -0.35 2.06e-11 Schizophrenia; LUSC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg03929089 chr4:120376271 NA -0.98 -16.4 -0.67 9.19e-45 Coronary artery disease; LUSC cis rs11048434 0.761 rs2377675 chr12:9124765 C/T cg13575925 chr12:9217583 LOC144571 0.34 6.07 0.32 3.51e-9 Sjögren's syndrome; LUSC cis rs672059 0.967 rs657901 chr1:183163411 T/G ch.1.3577855R chr1:183094577 LAMC1 0.55 8.1 0.41 1.04e-14 Hypertriglyceridemia; LUSC cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg21545522 chr1:205238299 TMCC2 0.51 9.69 0.47 9.59e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs698813 0.604 rs1596009 chr2:44492102 G/T cg00619915 chr2:44497795 NA -0.53 -7.51 -0.38 5.62e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC trans rs35110281 0.748 rs1584918 chr21:45042419 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.54 0.53 3.8e-26 Mean corpuscular volume; LUSC cis rs61931739 0.927 rs12315970 chr12:34038535 A/G cg06521331 chr12:34319734 NA 0.4 6.62 0.34 1.44e-10 Morning vs. evening chronotype; LUSC cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs36093844 0.590 rs10898402 chr11:85498447 C/G cg25872744 chr11:85566296 CCDC83 -0.43 -6.67 -0.34 1.04e-10 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs936229 0.813 rs1350193 chr15:75084281 G/C cg10253484 chr15:75165896 SCAMP2 -0.51 -6.72 -0.34 8.07e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg04944784 chr2:26401820 FAM59B 0.64 8.28 0.41 3.09e-15 Gut microbiome composition (summer); LUSC trans rs72674100 1.000 rs72880559 chr4:97975513 A/G cg16405019 chr1:18959625 PAX7 -0.64 -6.78 -0.35 5.33e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs10779751 0.770 rs12041740 chr1:11236524 G/A cg08854313 chr1:11322531 MTOR 0.87 14.05 0.61 1.55e-35 Body mass index; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg09436375 chr6:42928200 GNMT -0.3 -6.8 -0.35 4.73e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12310956 0.532 rs6488186 chr12:33974122 G/A cg06521331 chr12:34319734 NA -0.47 -7.55 -0.38 4.27e-13 Morning vs. evening chronotype; LUSC cis rs11158026 0.603 rs68065548 chr14:55446553 C/T cg04306507 chr14:55594613 LGALS3 0.4 7.37 0.37 1.39e-12 Parkinson's disease; LUSC cis rs7589342 0.839 rs12995333 chr2:106436366 A/C cg14210321 chr2:106509881 NCK2 0.54 8.09 0.4 1.11e-14 Addiction; LUSC cis rs12122100 0.913 rs61838896 chr1:146513139 A/G cg03526459 chr1:146549940 NA -0.42 -6.75 -0.35 6.47e-11 HIV-1 control; LUSC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg24562669 chr7:97807699 LMTK2 -0.35 -6.27 -0.32 1.14e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7188861 0.681 rs12162021 chr16:11403013 G/A cg00044050 chr16:11439710 C16orf75 0.59 6.1 0.32 2.99e-9 HDL cholesterol; LUSC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.75 0.39 1.08e-13 Bipolar disorder; LUSC cis rs970548 0.688 rs2082110 chr10:45931070 A/G cg15590007 chr10:45870220 ALOX5 0.55 6.34 0.33 7.67e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg22963979 chr7:1858916 MAD1L1 -0.5 -7.46 -0.38 7.42e-13 Schizophrenia; LUSC cis rs2562456 0.917 rs2681389 chr19:21692575 G/A cg00806126 chr19:22604979 ZNF98 0.37 5.71 0.3 2.5e-8 Pain; LUSC cis rs7914558 0.966 rs12766205 chr10:104893568 A/G cg05855489 chr10:104503620 C10orf26 0.6 9.68 0.47 1.1e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg16405210 chr4:1374714 KIAA1530 -0.53 -8.02 -0.4 1.78e-14 Obesity-related traits; LUSC cis rs7944584 0.552 rs12361415 chr11:47474146 T/G cg20307385 chr11:47447363 PSMC3 0.83 11.89 0.55 2.07e-27 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs34421088 0.560 rs2245357 chr8:11399484 A/T cg06636001 chr8:8085503 FLJ10661 -0.6 -9.39 -0.46 9.29e-19 Neuroticism; LUSC cis rs1018836 0.595 rs2223010 chr8:91480068 A/G cg16814680 chr8:91681699 NA -0.65 -9.69 -0.47 9.64e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs11792861 0.926 rs72607172 chr9:111876523 A/G cg05043794 chr9:111880884 C9orf5 -0.36 -7.61 -0.38 2.86e-13 Menarche (age at onset); LUSC cis rs2762353 0.524 rs9467596 chr6:25783022 A/G cg12310025 chr6:25882481 NA 0.34 5.79 0.3 1.61e-8 Blood metabolite levels; LUSC cis rs17270561 0.609 rs7770037 chr6:25760591 G/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs4808199 0.948 rs2074300 chr19:19380996 G/T cg03709012 chr19:19516395 GATAD2A 0.96 11.21 0.52 5.67e-25 Nonalcoholic fatty liver disease; LUSC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg27121462 chr16:89883253 FANCA -0.5 -7.49 -0.38 6.09e-13 Vitiligo; LUSC cis rs500891 0.533 rs9361995 chr6:84126776 C/T cg08257003 chr6:84140564 ME1 0.35 8.66 0.43 2.02e-16 Platelet-derived growth factor BB levels; LUSC cis rs96067 0.805 rs12033824 chr1:36600307 C/T cg24686825 chr1:36642396 MAP7D1 -0.42 -5.91 -0.31 8.42e-9 Corneal structure; LUSC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19717773 chr7:2847554 GNA12 -0.45 -7.82 -0.39 6.88e-14 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs9341835 0.772 rs4710254 chr6:64137609 C/T cg03326410 chr6:64151739 NA -0.38 -6.26 -0.32 1.15e-9 Schizophrenia; LUSC cis rs9612 0.948 rs12609587 chr19:44268654 T/C cg08581076 chr19:44259116 C19orf61 0.48 5.92 0.31 8.17e-9 Exhaled nitric oxide output; LUSC cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg16797656 chr11:68205561 LRP5 0.37 6.17 0.32 2.03e-9 Total body bone mineral density; LUSC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg08280861 chr8:58055591 NA 0.56 6.05 0.31 3.96e-9 Developmental language disorder (linguistic errors); LUSC cis rs8114671 0.935 rs35193912 chr20:33785050 C/T cg24642439 chr20:33292090 TP53INP2 -0.41 -5.93 -0.31 7.41e-9 Height; LUSC cis rs6693567 0.565 rs1776275 chr1:150269437 G/T cg15654264 chr1:150340011 RPRD2 -0.47 -7.69 -0.39 1.65e-13 Migraine; LUSC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11644478 chr21:40555479 PSMG1 0.94 18.71 0.72 5.98e-54 Cognitive function; LUSC cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs1538970 0.847 rs781230 chr1:45880751 C/T cg05343316 chr1:45956843 TESK2 -0.6 -8.39 -0.42 1.36e-15 Platelet count; LUSC cis rs950169 0.519 rs7237 chr15:85186577 C/T cg17173187 chr15:85201210 NMB 0.45 8.52 0.42 5.75e-16 Schizophrenia; LUSC cis rs8060686 0.668 rs8048034 chr16:68210604 A/G cg09835421 chr16:68378352 PRMT7 -0.45 -5.71 -0.3 2.45e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg09469691 chr10:81107165 PPIF 0.67 10.91 0.51 6.35e-24 Height; LUSC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg25456477 chr12:86230367 RASSF9 0.41 7.24 0.37 3.2e-12 Major depressive disorder; LUSC cis rs6084875 0.840 rs6052822 chr20:4726510 T/G cg26097573 chr20:4721490 PRNT -0.31 -5.74 -0.3 2.16e-8 Systemic lupus erythematosus; LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg18404041 chr3:52824283 ITIH1 -0.58 -11.18 -0.52 7.29e-25 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21487267 chr8:41386754 GINS4 -0.43 -6.6 -0.34 1.59e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6977660 0.714 rs6976972 chr7:19818315 C/A cg05791153 chr7:19748676 TWISTNB 0.66 7.0 0.36 1.38e-11 Thyroid stimulating hormone; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11830880 chr17:34136324 TAF15 0.45 6.1 0.32 2.87e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs62400317 0.859 rs10948219 chr6:45229307 A/T cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs314370 0.855 rs17883557 chr7:100494949 G/T cg10426581 chr7:100472382 SRRT 0.86 12.37 0.56 3.44e-29 Resting heart rate; LUSC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg16434002 chr17:42200994 HDAC5 0.43 5.84 0.3 1.26e-8 Total body bone mineral density; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg13710969 chr17:79393463 BAHCC1 -0.29 -6.66 -0.34 1.11e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10791097 0.694 rs2155750 chr11:130751261 A/C cg12179176 chr11:130786555 SNX19 0.86 15.14 0.64 8.29e-40 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs7909074 1.000 rs12777258 chr10:45394961 A/G cg04218760 chr10:45406644 TMEM72 0.33 7.88 0.4 4.77e-14 Mean corpuscular volume; LUSC cis rs17685 0.743 rs10277259 chr7:75802674 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg08847533 chr14:75593920 NEK9 0.8 13.43 0.59 3.65e-33 Height; LUSC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg15556689 chr8:8085844 FLJ10661 0.7 11.61 0.54 2.14e-26 Mood instability; LUSC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg23158103 chr7:148848205 ZNF398 -0.42 -6.65 -0.34 1.18e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs854765 0.624 rs4925116 chr17:17731200 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.71 -11.94 -0.55 1.27e-27 Total body bone mineral density; LUSC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg22029157 chr1:209979665 IRF6 -0.62 -9.92 -0.48 1.63e-20 Monobrow; LUSC cis rs11167764 0.895 rs9324865 chr5:141488792 T/C cg23435118 chr5:141488016 NDFIP1 -0.53 -7.38 -0.37 1.3e-12 Crohn's disease; LUSC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg13206674 chr6:150067644 NUP43 0.58 9.35 0.46 1.35e-18 Lung cancer; LUSC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg06238570 chr21:40685208 BRWD1 0.47 7.24 0.37 3.13e-12 Cognitive function; LUSC cis rs7607369 0.536 rs4646535 chr2:219664663 C/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.34 -0.46 1.37e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs8060686 0.641 rs12447931 chr16:68179195 C/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.75 -0.3 2.01e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs9473147 0.516 rs2151975 chr6:47515663 T/C cg02130027 chr6:47444894 CD2AP 0.36 5.74 0.3 2.09e-8 Platelet distribution width;Mean platelet volume; LUSC trans rs7829975 0.591 rs12677543 chr8:8644274 G/C cg21775007 chr8:11205619 TDH 0.45 6.45 0.33 3.87e-10 Mood instability; LUSC cis rs2692947 0.696 rs2576437 chr2:96800417 T/C cg22654517 chr2:96458247 NA 0.36 7.26 0.37 2.69e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg05754148 chr16:3507555 NAT15 -0.54 -8.28 -0.41 3.06e-15 Tuberculosis; LUSC cis rs10504073 0.647 rs4348510 chr8:50016027 C/A cg00325661 chr8:49890786 NA 0.62 10.34 0.49 6.46e-22 Blood metabolite ratios; LUSC cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.95 0.31 6.62e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4812048 0.649 rs3761258 chr20:57618596 C/G cg14073986 chr20:57617431 SLMO2 -0.87 -9.34 -0.46 1.4e-18 Mean platelet volume; LUSC cis rs7561273 0.586 rs11900665 chr2:24298198 T/C cg06627628 chr2:24431161 ITSN2 -0.51 -6.83 -0.35 4.03e-11 Quantitative traits; LUSC cis rs713477 0.524 rs7149317 chr14:55902542 G/A cg13175173 chr14:55914753 NA -0.31 -6.03 -0.31 4.43e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg19748678 chr4:122722346 EXOSC9 0.73 10.84 0.51 1.15e-23 Type 2 diabetes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07580707 chr3:14220061 XPC;LSM3 -0.48 -6.55 -0.34 2.2e-10 Bipolar disorder and schizophrenia; LUSC cis rs10751667 0.666 rs10902255 chr11:967268 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.4 0.33 5.39e-10 Alzheimer's disease (late onset); LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.97 -0.31 6.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11039798 0.764 rs11040030 chr11:48800985 C/T cg03929089 chr4:120376271 NA 0.72 6.77 0.35 5.71e-11 Axial length; LUSC cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.41 0.5 3.56e-22 Schizophrenia; LUSC cis rs926392 0.932 rs4812360 chr20:37689259 A/G cg27552599 chr20:37590471 DHX35 0.33 5.8 0.3 1.51e-8 Dialysis-related mortality; LUSC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg06558623 chr16:89946397 TCF25 0.85 8.28 0.41 3e-15 Skin colour saturation; LUSC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.22 -0.32 1.46e-9 Neuroticism; LUSC trans rs877282 0.945 rs11253388 chr10:787852 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs7589342 0.628 rs35622044 chr2:106404095 G/A cg14210321 chr2:106509881 NCK2 -0.45 -5.81 -0.3 1.49e-8 Addiction; LUSC cis rs17270561 0.609 rs7450798 chr6:25719280 T/A cg16482183 chr6:26056742 HIST1H1C 0.63 8.91 0.44 3.44e-17 Iron status biomarkers; LUSC cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.44 -8.17 -0.41 6.26e-15 Monocyte percentage of white cells; LUSC cis rs17401966 0.800 rs2039778 chr1:10354601 A/G cg19773385 chr1:10388646 KIF1B -0.5 -8.66 -0.43 2e-16 Hepatocellular carcinoma; LUSC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg06600287 chr1:53387719 ECHDC2 -0.31 -6.35 -0.33 7.19e-10 Monocyte count; LUSC cis rs12210905 0.925 rs7753284 chr6:26991615 G/C cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.95 -0.31 6.94e-9 Hip circumference adjusted for BMI; LUSC cis rs3733418 0.799 rs13110766 chr4:165956628 C/T cg11630554 chr4:165878136 TRIM61;C4orf39 -0.5 -6.49 -0.33 3.1e-10 Obesity-related traits; LUSC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -11.93 -0.55 1.44e-27 Hemoglobin concentration; LUSC cis rs7215564 0.908 rs35151535 chr17:78661695 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs10751667 0.643 rs12278229 chr11:946985 A/G ch.11.42038R chr11:967971 AP2A2 0.4 6.01 0.31 4.95e-9 Alzheimer's disease (late onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07023527 chr16:72699106 NA 0.81 6.57 0.34 1.9e-10 Cognitive performance; LUSC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg11301795 chr4:187892539 NA -0.81 -16.05 -0.66 2.25e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.562 rs2424999 chr20:33386430 G/A cg07148914 chr20:33460835 GGT7 0.54 8.28 0.41 3.01e-15 Height; LUSC cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.67 -0.43 1.88e-16 Body mass index; LUSC cis rs12477438 0.715 rs7586608 chr2:99558017 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.43 -0.56 2.07e-29 Chronic sinus infection; LUSC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg09034736 chr1:150693464 HORMAD1 0.44 6.32 0.33 8.16e-10 Melanoma; LUSC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg13319975 chr6:146136371 FBXO30 -0.51 -7.81 -0.39 7.54e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6076065 0.723 rs6083099 chr20:23358233 A/G cg11657817 chr20:23433608 CST11 -0.42 -7.85 -0.39 5.65e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs7851660 0.805 rs10759981 chr9:100635780 A/G cg13688889 chr9:100608707 NA -0.55 -8.73 -0.43 1.24e-16 Strep throat; LUSC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.53 8.04 0.4 1.6e-14 Axial length; LUSC trans rs11098499 0.863 rs12502389 chr4:120454191 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.66 0.34 1.16e-10 Corneal astigmatism; LUSC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC trans rs911555 0.755 rs2756135 chr14:103962579 G/A cg17675199 chr6:35436792 RPL10A -0.43 -6.32 -0.33 8.21e-10 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg25817165 chr18:72167213 CNDP2 -0.71 -9.26 -0.45 2.63e-18 Refractive error; LUSC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs11098499 0.909 rs78332141 chr4:120375782 C/T cg09307838 chr4:120376055 NA 0.77 10.81 0.51 1.49e-23 Corneal astigmatism; LUSC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.77 13.52 0.59 1.6e-33 Total body bone mineral density; LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg19318889 chr4:1322082 MAEA 0.77 14.21 0.61 3.61e-36 Longevity; LUSC cis rs12200782 0.505 rs1535275 chr6:26520767 G/C cg05738196 chr6:26577821 NA 0.52 6.12 0.32 2.56e-9 Small cell lung carcinoma; LUSC cis rs10492096 1.000 rs12427239 chr12:6590626 C/T cg13857086 chr12:6580257 VAMP1 0.58 6.78 0.35 5.5e-11 Hip geometry; LUSC cis rs7119038 0.774 rs11217020 chr11:118639353 G/A cg19308663 chr11:118741387 NA 0.36 6.17 0.32 1.96e-9 Sjögren's syndrome; LUSC cis rs500891 0.553 rs12194267 chr6:84146177 G/A cg08257003 chr6:84140564 ME1 0.35 7.74 0.39 1.18e-13 Platelet-derived growth factor BB levels; LUSC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg26727032 chr16:67993705 SLC12A4 -0.45 -5.89 -0.31 9.42e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg24324837 chr19:49891574 CCDC155 0.5 6.4 0.33 5.23e-10 Multiple sclerosis; LUSC cis rs6674970 0.932 rs12569193 chr1:151115186 C/T cg03258749 chr1:151040405 MLLT11 -0.42 -6.37 -0.33 6.13e-10 Childhood ear infection; LUSC cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.55 0.34 2.21e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7614311 0.681 rs73117083 chr3:63948455 G/C cg22134162 chr3:63841271 THOC7 -0.48 -5.89 -0.31 9.6e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs2404602 0.692 rs10444858 chr15:76962504 T/C cg26408565 chr15:76604113 ETFA -0.47 -7.5 -0.38 5.79e-13 Blood metabolite levels; LUSC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg17724175 chr1:150552817 MCL1 0.38 6.72 0.35 7.87e-11 Urate levels; LUSC cis rs61931739 0.963 rs12310956 chr12:33970682 A/G cg06521331 chr12:34319734 NA 0.38 6.08 0.32 3.2e-9 Morning vs. evening chronotype; LUSC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg10802521 chr3:52805072 NEK4 -0.54 -8.77 -0.43 9.05e-17 Bipolar disorder; LUSC cis rs752010 0.714 rs2148635 chr1:42082452 C/T cg06885757 chr1:42089581 HIVEP3 -0.47 -9.95 -0.48 1.38e-20 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs73001065 0.636 rs10415849 chr19:19505087 C/T cg03709012 chr19:19516395 GATAD2A 0.94 8.87 0.44 4.66e-17 LDL cholesterol; LUSC trans rs62238980 0.614 rs10483162 chr22:32394890 G/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs1493916 0.905 rs4799727 chr18:31393095 T/G cg15819921 chr19:927150 ARID3A -0.45 -6.72 -0.35 7.88e-11 Life satisfaction; LUSC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg19774624 chr17:42201019 HDAC5 -0.45 -6.47 -0.33 3.57e-10 Red cell distribution width;Reticulocyte count; LUSC cis rs11785400 1.000 rs7459630 chr8:143738585 A/C cg24634471 chr8:143751801 JRK 0.58 8.87 0.44 4.56e-17 Schizophrenia; LUSC cis rs68170813 0.559 rs76145119 chr7:107052368 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.32 -0.45 1.62e-18 Coronary artery disease; LUSC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg13770153 chr20:60521292 NA -0.46 -6.57 -0.34 1.99e-10 Body mass index; LUSC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.28 -0.32 1.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs11997175 0.600 rs6468188 chr8:33639478 T/C ch.8.33884649F chr8:33765107 NA 0.48 7.72 0.39 1.34e-13 Body mass index; LUSC cis rs709400 0.604 rs7158144 chr14:103887615 A/G cg10523860 chr14:103875565 MARK3 -0.39 -6.06 -0.31 3.71e-9 Body mass index; LUSC trans rs7746199 0.736 rs34064842 chr6:27688625 G/T cg06606381 chr12:133084897 FBRSL1 -0.94 -8.79 -0.43 8.32e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg20503657 chr10:835505 NA 0.73 8.85 0.44 5.35e-17 Eosinophil percentage of granulocytes; LUSC cis rs2200578 0.786 rs62154639 chr2:99646954 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.64 7.35 0.37 1.53e-12 IgG glycosylation; LUSC cis rs4776059 0.798 rs10851520 chr15:52912978 C/G cg25063058 chr15:52860530 ARPP19 -0.45 -5.72 -0.3 2.37e-8 Schizophrenia; LUSC cis rs11168618 0.846 rs7974213 chr12:48881492 C/T cg24011408 chr12:48396354 COL2A1 -0.4 -6.5 -0.34 2.89e-10 Adiponectin levels; LUSC cis rs7582180 0.675 rs4851313 chr2:101029002 A/G cg08017756 chr2:100939284 LONRF2 0.41 7.66 0.39 2.07e-13 Intelligence (multi-trait analysis); LUSC trans rs12579753 0.833 rs12579530 chr12:82163930 A/C cg07923666 chr12:49932857 KCNH3 -0.48 -6.22 -0.32 1.48e-9 Resting heart rate; LUSC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg18190219 chr22:46762943 CELSR1 -0.52 -5.96 -0.31 6.55e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg25039879 chr17:56429692 SUPT4H1 0.41 5.85 0.3 1.17e-8 Cognitive test performance; LUSC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.6 0.38 2.92e-13 Parkinson's disease; LUSC cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.15e-8 Breast cancer; LUSC trans rs8072100 0.807 rs2175290 chr17:45479917 C/A cg04995722 chr7:26192034 NFE2L3 -0.39 -6.32 -0.33 8.15e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6736093 0.966 rs2271701 chr2:112731173 C/G cg12686935 chr2:112915763 FBLN7 -0.36 -5.9 -0.31 9.09e-9 Coronary artery disease; LUSC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg12365402 chr11:9010492 NRIP3 -0.47 -8.98 -0.44 2.03e-17 Hemoglobin concentration; LUSC cis rs9467773 0.506 rs9393709 chr6:26365147 C/T cg05738196 chr6:26577821 NA -0.47 -7.31 -0.37 2e-12 Intelligence (multi-trait analysis); LUSC cis rs9287719 0.967 rs9679581 chr2:10751736 G/A cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg23306229 chr2:178417860 TTC30B -0.53 -5.7 -0.3 2.61e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11677370 0.603 rs11675498 chr2:3850943 G/T cg17052675 chr2:3827356 NA -0.64 -10.2 -0.49 1.87e-21 Type 2 diabetes; LUSC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg23172400 chr8:95962367 TP53INP1 -0.3 -5.81 -0.3 1.49e-8 Type 2 diabetes; LUSC cis rs8114671 0.836 rs2038504 chr20:33648187 T/C cg24642439 chr20:33292090 TP53INP2 -0.41 -5.86 -0.31 1.09e-8 Height; LUSC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg09509183 chr1:209979624 IRF6 -0.48 -7.52 -0.38 4.94e-13 Monobrow; LUSC cis rs9942416 0.660 rs34905687 chr5:74997736 A/G cg19683494 chr5:74908142 NA 0.45 6.9 0.35 2.58e-11 Age-related disease endophenotypes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16041806 chr1:173991823 NA 0.4 6.54 0.34 2.29e-10 Triglycerides; LUSC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.76 -0.47 5.77e-20 Chronic sinus infection; LUSC cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg17366294 chr4:99064904 C4orf37 0.62 11.15 0.52 9.52e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg16584290 chr5:462447 EXOC3 -0.34 -5.8 -0.3 1.57e-8 Cystic fibrosis severity; LUSC cis rs7241530 0.662 rs6506756 chr18:75905196 C/G cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg11812906 chr14:75593930 NEK9 0.66 11.36 0.53 1.59e-25 Height; LUSC cis rs3857536 0.740 rs4710571 chr6:66890250 T/C cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs28595532 1.000 rs11098451 chr4:119717673 C/T cg02775129 chr4:119771670 NA -0.74 -5.91 -0.31 8.36e-9 Cannabis dependence symptom count; LUSC cis rs4589502 0.925 rs4259997 chr15:67153310 A/G cg12317470 chr15:67143691 NA -0.61 -7.06 -0.36 9.86e-12 Lung cancer (smoking interaction); LUSC cis rs10484885 0.588 rs9344947 chr6:90304789 A/G cg13799429 chr6:90582589 CASP8AP2 0.68 7.26 0.37 2.72e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs868036 0.672 rs7175517 chr15:68077630 A/G cg27219399 chr15:67835830 MAP2K5 0.34 5.66 0.3 3.33e-8 Restless legs syndrome; LUSC cis rs709400 0.604 rs7158144 chr14:103887615 A/G cg12935359 chr14:103987150 CKB -0.57 -8.6 -0.43 3.09e-16 Body mass index; LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.46 -0.5 2.44e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg24733560 chr20:60626293 TAF4 0.41 6.56 0.34 2.04e-10 Body mass index; LUSC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.69 -0.39 1.7e-13 Developmental language disorder (linguistic errors); LUSC trans rs7615952 0.688 rs12638224 chr3:125541320 C/T cg07211511 chr3:129823064 LOC729375 -1.0 -13.81 -0.6 1.2e-34 Blood pressure (smoking interaction); LUSC cis rs6500395 1.000 rs9937610 chr16:48671274 C/G cg04672837 chr16:48644449 N4BP1 0.46 6.73 0.35 7.32e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg12935359 chr14:103987150 CKB -0.62 -10.18 -0.49 2.24e-21 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.34 -0.49 6.57e-22 Obesity-related traits; LUSC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.09 0.52 1.52e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7851660 0.844 rs10984103 chr9:100639275 G/T cg13688889 chr9:100608707 NA 0.54 8.4 0.42 1.27e-15 Strep throat; LUSC trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg17830980 chr10:43048298 ZNF37B 0.57 9.25 0.45 2.76e-18 Extrinsic epigenetic age acceleration; LUSC cis rs17270561 0.609 rs12663099 chr6:25739518 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC cis rs11098499 0.532 rs4504231 chr4:120586891 G/A cg09307838 chr4:120376055 NA 0.66 9.29 0.45 2.07e-18 Corneal astigmatism; LUSC cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg05340658 chr4:99064831 C4orf37 0.67 11.45 0.53 7.92e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs11997175 0.756 rs4739435 chr8:33818818 A/G ch.8.33884649F chr8:33765107 NA 0.53 8.16 0.41 6.69e-15 Body mass index; LUSC cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg00677455 chr12:58241039 CTDSP2 0.69 10.45 0.5 2.74e-22 Intelligence (multi-trait analysis); LUSC cis rs7100689 0.646 rs1538815 chr10:82137670 A/G cg01528321 chr10:82214614 TSPAN14 0.87 13.25 0.59 1.64e-32 Post bronchodilator FEV1; LUSC cis rs2067615 0.579 rs10861663 chr12:107183589 G/A cg15890332 chr12:107067104 RFX4 0.34 6.06 0.31 3.76e-9 Heart rate; LUSC cis rs11098499 0.754 rs7672372 chr4:120248406 A/G cg24375607 chr4:120327624 NA 0.77 12.34 0.56 4.45e-29 Corneal astigmatism; LUSC cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg00530320 chr1:46809349 NSUN4 -0.57 -9.01 -0.44 1.61e-17 Menopause (age at onset); LUSC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg16606324 chr3:10149918 C3orf24 -0.42 -6.79 -0.35 5e-11 Alzheimer's disease; LUSC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg11965913 chr1:205819406 PM20D1 0.45 6.41 0.33 5e-10 Parkinson's disease; LUSC trans rs61931739 0.534 rs11053029 chr12:34131766 G/T cg13010199 chr12:38710504 ALG10B 0.56 8.55 0.42 4.54e-16 Morning vs. evening chronotype; LUSC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg06212747 chr3:49208901 KLHDC8B 0.45 5.85 0.31 1.14e-8 Parkinson's disease; LUSC cis rs3740713 1.000 rs2643872 chr11:18450444 A/T cg07915343 chr11:18477680 LDHAL6A -0.54 -6.79 -0.35 5.16e-11 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs73206853 0.764 rs61227741 chr12:110598319 G/T cg12870014 chr12:110450643 ANKRD13A 0.62 6.3 0.33 9.4e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6500395 1.000 rs6500395 chr16:48621402 T/C cg04672837 chr16:48644449 N4BP1 0.49 7.28 0.37 2.46e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11971779 0.648 rs9656512 chr7:139054046 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7917772 0.582 rs7087984 chr10:104380686 G/A cg05855489 chr10:104503620 C10orf26 -0.5 -7.45 -0.38 8.21e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg11766577 chr21:47581405 C21orf56 -0.46 -6.84 -0.35 3.84e-11 Testicular germ cell tumor; LUSC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg07828024 chr6:149772892 ZC3H12D -0.34 -7.43 -0.38 8.88e-13 Dupuytren's disease; LUSC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs6062509 0.931 rs4809329 chr20:62348460 C/T cg21849932 chr20:62369462 LIME1 -0.41 -6.02 -0.31 4.7e-9 Prostate cancer; LUSC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg19784903 chr17:45786737 TBKBP1 -0.42 -6.15 -0.32 2.24e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2882667 0.690 rs9942422 chr5:138272536 A/G cg04439458 chr5:138467593 SIL1 -0.41 -7.46 -0.38 7.63e-13 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg19920283 chr7:105172520 RINT1 0.61 6.76 0.35 6.2e-11 Bipolar disorder (body mass index interaction); LUSC trans rs6502050 0.805 rs6502061 chr17:80086158 C/T cg07393940 chr7:158741817 NA -0.38 -6.83 -0.35 4.02e-11 Life satisfaction; LUSC cis rs7119 0.637 rs12913005 chr15:77856571 T/A cg27398640 chr15:77910606 LINGO1 -0.36 -7.84 -0.39 6.18e-14 Type 2 diabetes; LUSC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg06108461 chr20:60628389 TAF4 -1.01 -17.18 -0.68 7.55e-48 Body mass index; LUSC trans rs10435719 0.580 rs13260712 chr8:11782570 A/C cg14343924 chr8:8086146 FLJ10661 -0.45 -6.23 -0.32 1.43e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs11098499 1.000 rs28374891 chr4:120183550 G/A cg09307838 chr4:120376055 NA 0.7 10.0 0.48 9.4499999999999992e-21 Corneal astigmatism; LUSC trans rs3824451 1.000 rs10985817 chr9:101071090 T/C cg02729030 chr7:110879415 IMMP2L 0.44 6.03 0.31 4.41e-9 Schizophrenia; LUSC cis rs9814567 1.000 rs7611828 chr3:134250325 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9914988 1.000 rs9914988 chr17:27183104 G/A cg09479241 chr17:27052676 TLCD1 -0.4 -5.69 -0.3 2.85e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs7395662 0.591 rs4882110 chr11:48558249 G/T cg15704280 chr7:45808275 SEPT13 -0.46 -6.35 -0.33 6.87e-10 HDL cholesterol; LUSC trans rs629535 0.508 rs56207225 chr8:70146628 C/A cg21567404 chr3:27674614 NA -0.93 -13.53 -0.6 1.45e-33 Dupuytren's disease; LUSC cis rs2835872 0.965 rs2835853 chr21:39014892 C/A cg20424643 chr21:39039972 KCNJ6 0.43 6.47 0.33 3.47e-10 Electroencephalographic traits in alcoholism; LUSC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg16743903 chr16:89593216 SPG7 -0.38 -6.07 -0.32 3.42e-9 Multiple myeloma (IgH translocation); LUSC cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg05234568 chr11:5960015 NA -0.65 -9.41 -0.46 8.45e-19 DNA methylation (variation); LUSC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg16325326 chr1:53192061 ZYG11B 0.97 18.46 0.71 6.26e-53 Monocyte count; LUSC cis rs10934753 0.632 rs2001273 chr3:125926110 C/T cg01346077 chr3:125931526 NA 0.48 8.88 0.44 4.28e-17 Plasma homocysteine levels (post-methionine load test); LUSC cis rs10979 1.000 rs9386032 chr6:143887492 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.01 -0.55 7.28e-28 Hypospadias; LUSC cis rs78572108 0.858 rs72613884 chr2:42264869 A/G cg00607755 chr2:42274082 PKDCC 0.37 6.56 0.34 2.03e-10 Total body bone mineral density; LUSC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg24110177 chr3:50126178 RBM5 -0.55 -8.98 -0.44 2.05e-17 Intelligence (multi-trait analysis); LUSC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg15704280 chr7:45808275 SEPT13 -0.99 -16.97 -0.68 5.26e-47 Coronary artery disease; LUSC cis rs4319547 0.661 rs10846830 chr12:122897220 C/G cg23029597 chr12:123009494 RSRC2 -0.72 -9.25 -0.45 2.74e-18 Body mass index; LUSC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg13866156 chr1:1669148 SLC35E2 -0.49 -8.0 -0.4 2.08e-14 Body mass index; LUSC cis rs9467773 1.000 rs1078679 chr6:26568741 C/T cg11502198 chr6:26597334 ABT1 0.64 10.07 0.48 5.3e-21 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg24531977 chr5:56204891 C5orf35 -0.71 -10.4 -0.49 3.84e-22 Coronary artery disease; LUSC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg17509989 chr5:176798049 RGS14 -0.67 -11.0 -0.52 3.08e-24 Urinary electrolytes (magnesium/calcium ratio); LUSC cis rs11785400 1.000 rs13265663 chr8:143732255 A/C cg10596483 chr8:143751796 JRK 0.62 9.5 0.46 4.11e-19 Schizophrenia; LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg13732083 chr21:47605072 C21orf56 0.46 6.94 0.35 2.07e-11 Testicular germ cell tumor; LUSC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg23711669 chr6:146136114 FBXO30 -0.75 -12.1 -0.55 3.52e-28 Lobe attachment (rater-scored or self-reported); LUSC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg00631329 chr6:26305371 NA 0.33 5.78 0.3 1.68e-8 Intelligence (multi-trait analysis); LUSC trans rs561341 1.000 rs560132 chr17:30320019 C/T cg27661571 chr11:113659931 NA -0.71 -8.16 -0.41 6.87e-15 Hip circumference adjusted for BMI; LUSC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg00255919 chr5:131827918 IRF1 0.4 7.31 0.37 2.02e-12 Asthma (sex interaction); LUSC cis rs7572644 0.723 rs12473400 chr2:28024024 G/T cg27432699 chr2:27873401 GPN1 0.55 7.23 0.37 3.31e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs3106136 0.967 rs282448 chr4:95141411 T/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.12 -0.32 2.68e-9 Capecitabine sensitivity; LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg08280861 chr8:58055591 NA 0.54 5.89 0.31 9.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.51 -0.34 2.73e-10 Bipolar disorder and schizophrenia; LUSC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.56 9.64 0.47 1.44e-19 Multiple sclerosis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg15137760 chr8:21988747 HR 0.8 6.84 0.35 3.68e-11 Cognitive performance; LUSC trans rs7044246 0.924 rs9411424 chr9:134864382 C/T cg17477578 chr8:129552914 NA 0.32 5.97 0.31 6.13e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06463759 chr7:128502823 ATP6V1F 0.5 8.15 0.41 7.49e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs17685 0.712 rs6976236 chr7:75741087 G/T cg19862616 chr7:65841803 NCRNA00174 1.11 18.8 0.72 2.7e-54 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg23158103 chr7:148848205 ZNF398 -0.5 -8.17 -0.41 6.41e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12122100 0.651 rs12728300 chr1:146542184 T/C cg03526459 chr1:146549940 NA -0.42 -6.76 -0.35 6.19e-11 HIV-1 control; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.67 10.06 0.48 5.62e-21 Lymphocyte counts; LUSC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg21724239 chr8:58056113 NA 0.56 6.92 0.35 2.35e-11 Developmental language disorder (linguistic errors); LUSC cis rs892961 0.867 rs1079354 chr17:75415713 C/T cg05865280 chr17:75406074 SEPT9 0.45 9.47 0.46 5.42e-19 Airflow obstruction; LUSC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg07828024 chr6:149772892 ZC3H12D 0.33 7.13 0.36 6.14e-12 Dupuytren's disease; LUSC cis rs34779708 0.931 rs12768019 chr10:35389843 T/C cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9399401 0.925 rs2039987 chr6:142655490 A/C cg03128060 chr6:142623767 GPR126 0.33 5.87 0.31 1.03e-8 Chronic obstructive pulmonary disease; LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg23758822 chr17:41437982 NA 1.04 19.22 0.72 5.83e-56 Menopause (age at onset); LUSC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg21138405 chr5:131827807 IRF1 -0.6 -11.83 -0.54 3.22e-27 Asthma (sex interaction); LUSC cis rs9462027 0.628 rs9368832 chr6:34679587 C/T cg07306190 chr6:34760872 UHRF1BP1 0.33 5.79 0.3 1.65e-8 Systemic lupus erythematosus; LUSC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 14.51 0.62 2.45e-37 Platelet count; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg24436578 chr11:2398521 CD81 0.35 5.98 0.31 5.78e-9 Metabolite levels (Pyroglutamine); LUSC cis rs2011503 0.941 rs55822665 chr19:19383298 C/T cg11584989 chr19:19387371 SF4 0.57 6.82 0.35 4.18e-11 Bipolar disorder; LUSC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg24881330 chr22:46731750 TRMU 0.88 8.84 0.44 5.44e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs61990749 0.597 rs717683 chr14:78255453 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.45 0.33 3.84e-10 Fibroblast growth factor basic levels; LUSC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.86 0.31 1.14e-8 Menopause (age at onset); LUSC cis rs9916302 0.706 rs6503521 chr17:37715551 A/C cg07936489 chr17:37558343 FBXL20 0.76 9.28 0.45 2.14e-18 Glomerular filtration rate (creatinine); LUSC trans rs12637928 0.580 rs13081130 chr3:110210864 G/C cg17371621 chr15:61264283 RORA 0.36 6.08 0.32 3.29e-9 Neuroticism; LUSC cis rs877282 0.945 rs12776447 chr10:790625 A/G cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg15691649 chr6:25882328 NA 0.5 7.5 0.38 5.92e-13 Blood metabolite levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09667226 chr13:73632762 KLF5 0.44 6.53 0.34 2.46e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4704187 0.687 rs6872475 chr5:74419793 G/A cg03227963 chr5:74354835 NA 0.32 6.81 0.35 4.62e-11 Response to amphetamines; LUSC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.13e-12 Mean platelet volume; LUSC cis rs7582720 0.943 rs72926800 chr2:203829225 A/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2404602 0.646 rs3764245 chr15:77223176 G/C cg23625390 chr15:77176239 SCAPER 0.67 10.48 0.5 2.02e-22 Blood metabolite levels; LUSC cis rs7127900 0.614 rs72853920 chr11:2206429 T/C cg25635251 chr11:2234043 NA -0.6 -8.13 -0.41 8.32e-15 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); LUSC cis rs7903847 0.642 rs12359257 chr10:99136359 A/T cg20016023 chr10:99160130 RRP12 -0.37 -8.68 -0.43 1.83e-16 Granulocyte percentage of myeloid white cells; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg07332563 chr6:291687 DUSP22 -0.5 -7.62 -0.38 2.67e-13 Menopause (age at onset); LUSC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg02415014 chr8:143852576 LYNX1 0.35 8.32 0.41 2.21e-15 Urinary tract infection frequency; LUSC cis rs6723226 0.650 rs6729952 chr2:32764922 T/C cg02381751 chr2:32503542 YIPF4 0.49 7.36 0.37 1.49e-12 Intelligence (multi-trait analysis); LUSC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.5 6.87 0.35 3.08e-11 Multiple sclerosis; LUSC cis rs4660306 0.961 rs937290 chr1:45961955 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.09 -0.36 8.2e-12 Homocysteine levels; LUSC cis rs367615 0.704 rs55956735 chr5:108845042 A/G cg17395555 chr5:108820864 NA 0.61 11.15 0.52 9.41e-25 Colorectal cancer (SNP x SNP interaction); LUSC trans rs62238980 0.614 rs75321866 chr22:32460707 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg03146154 chr1:46216737 IPP -0.55 -8.08 -0.4 1.22e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs17253792 0.822 rs77555779 chr14:56078430 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg06637938 chr14:75390232 RPS6KL1 0.53 8.61 0.43 2.95e-16 Height; LUSC cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2652834 0.851 rs2652796 chr15:63408042 T/A cg05507819 chr15:63340323 TPM1 0.46 5.94 0.31 7.3e-9 HDL cholesterol; LUSC cis rs1577917 0.696 rs2842617 chr6:86309698 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.98 -0.36 1.58e-11 Response to antipsychotic treatment; LUSC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg17385448 chr1:15911702 AGMAT 0.38 6.42 0.33 4.64e-10 Systolic blood pressure; LUSC trans rs1973993 0.967 rs11165643 chr1:96924097 C/T cg10631902 chr5:14652156 NA 0.53 8.86 0.44 4.82e-17 Weight; LUSC trans rs2288327 0.841 rs16866418 chr2:179490954 C/T cg14011486 chr1:26737247 LIN28 0.46 5.95 0.31 6.61e-9 Atrial fibrillation; LUSC cis rs7705502 1.000 rs72812842 chr5:173374760 C/T cg18693985 chr5:173351052 CPEB4 -0.37 -5.86 -0.31 1.11e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs6502050 0.835 rs9900072 chr17:80114360 C/G cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs1979679 0.572 rs6487692 chr12:28726042 C/T cg13890972 chr12:28721907 NA -0.43 -6.12 -0.32 2.56e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs73206853 0.698 rs73194015 chr12:111116651 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.52 0.34 2.65e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs611744 0.647 rs633901 chr8:109242981 G/T cg18478394 chr8:109455254 TTC35 0.41 6.32 0.33 8.55e-10 Dupuytren's disease; LUSC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg15556689 chr8:8085844 FLJ10661 -0.58 -8.87 -0.44 4.48e-17 Systolic blood pressure; LUSC cis rs9287719 0.967 rs7587114 chr2:10739963 C/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs12122100 0.837 rs6681167 chr1:146506862 C/T cg03526459 chr1:146549940 NA 0.36 5.87 0.31 1.06e-8 HIV-1 control; LUSC cis rs1448094 0.842 rs7978562 chr12:86451478 A/G cg00310523 chr12:86230176 RASSF9 0.35 6.23 0.32 1.44e-9 Major depressive disorder; LUSC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg04287289 chr16:89883240 FANCA -0.5 -7.97 -0.4 2.61e-14 Vitiligo; LUSC cis rs4595586 0.505 rs11611321 chr12:39390803 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs7705502 1.000 rs72812816 chr5:173356638 G/A cg18693985 chr5:173351052 CPEB4 -0.37 -5.82 -0.3 1.35e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.09 -0.48 4.66e-21 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.863 rs7678400 chr4:120461957 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.75 0.39 1.12e-13 Corneal astigmatism; LUSC cis rs9914988 0.832 rs35033748 chr17:27179590 T/C cg07195577 chr17:27052828 TLCD1 0.44 5.67 0.3 3.15e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg13628971 chr7:2884303 GNA12 0.49 6.79 0.35 5.12e-11 Height; LUSC cis rs4595586 0.655 rs7953715 chr12:39325539 T/C cg26384229 chr12:38710491 ALG10B 0.44 5.97 0.31 6.12e-9 Morning vs. evening chronotype; LUSC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg14343924 chr8:8086146 FLJ10661 -0.42 -5.78 -0.3 1.71e-8 Neuroticism; LUSC cis rs9788682 0.948 rs59683676 chr15:78833453 T/C cg18825076 chr15:78729989 IREB2 0.46 6.23 0.32 1.39e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs11690935 0.921 rs7355523 chr2:172744421 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.36 -0.62 9.67e-37 Schizophrenia; LUSC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg12560992 chr17:57184187 TRIM37 0.9 17.84 0.7 1.78e-50 Intelligence (multi-trait analysis); LUSC cis rs826838 0.616 rs2387921 chr12:38624767 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.75 -0.35 6.46e-11 Heart rate; LUSC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg06850241 chr22:41845214 NA -0.31 -5.7 -0.3 2.7e-8 Vitiligo; LUSC cis rs2115536 0.606 rs8024713 chr15:80206958 C/G cg00225070 chr15:80189496 MTHFS 0.62 9.98 0.48 1.04e-20 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg11062466 chr8:58055876 NA 0.58 8.24 0.41 3.94e-15 Developmental language disorder (linguistic errors); LUSC cis rs7131987 0.903 rs67150462 chr12:29393325 T/C cg09582351 chr12:29534625 ERGIC2 -0.32 -6.58 -0.34 1.79e-10 QT interval; LUSC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg18681998 chr4:17616180 MED28 0.77 13.74 0.6 2.29e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9467773 1.000 rs2393670 chr6:26535541 A/G cg05738196 chr6:26577821 NA 0.82 15.82 0.65 1.9e-42 Intelligence (multi-trait analysis); LUSC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18301423 chr5:131593218 PDLIM4 0.47 7.42 0.38 9.66e-13 Acylcarnitine levels; LUSC trans rs2262909 0.962 rs439574 chr19:22232024 A/C cg05197062 chr11:11642011 GALNTL4 -0.49 -6.9 -0.35 2.54e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs500891 0.533 rs13204045 chr6:84152329 C/T cg08257003 chr6:84140564 ME1 0.37 9.01 0.44 1.57e-17 Platelet-derived growth factor BB levels; LUSC cis rs78545713 0.649 rs11754368 chr6:26221173 G/A cg23601095 chr6:26197514 HIST1H3D 0.66 5.79 0.3 1.64e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs13082711 0.595 rs6783818 chr3:27361988 C/G cg02860705 chr3:27208620 NA 0.8 12.69 0.57 2.23e-30 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs11122272 0.735 rs2437148 chr1:231513979 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg20573242 chr4:122745356 CCNA2 0.67 10.52 0.5 1.49e-22 Type 2 diabetes; LUSC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg05855489 chr10:104503620 C10orf26 0.6 9.61 0.47 1.88e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs3806843 1.000 rs10066278 chr5:140156318 A/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.29 -5.76 -0.3 1.95e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11132352 chr1:161719642 DUSP12 -0.41 -6.11 -0.32 2.84e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.46 -8.96 -0.44 2.28e-17 Monocyte percentage of white cells; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00850756 chr6:41909180 CCND3 0.38 6.39 0.33 5.53e-10 Asthma; LUSC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg16423285 chr20:60520624 NA -0.64 -8.15 -0.41 7.59e-15 Body mass index; LUSC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg25036284 chr2:26402008 FAM59B -0.68 -9.38 -0.46 1.06e-18 Gut microbiome composition (summer); LUSC cis rs11779988 0.545 rs375203 chr8:17769054 T/A cg01800426 chr8:17659068 MTUS1 -0.44 -5.77 -0.3 1.79e-8 Breast cancer; LUSC cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg23649088 chr2:200775458 C2orf69 0.59 7.28 0.37 2.36e-12 Schizophrenia; LUSC cis rs3087591 0.708 rs2854320 chr17:29694063 C/A cg24425628 chr17:29625626 OMG;NF1 0.49 7.25 0.37 2.9e-12 Hip circumference; LUSC cis rs75804782 0.641 rs72983861 chr2:239326126 G/A cg18131467 chr2:239335373 ASB1 -0.74 -6.52 -0.34 2.57e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg13114125 chr14:105738426 BRF1 -0.92 -15.78 -0.65 2.58e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs12980942 0.935 rs11880564 chr19:41831196 C/A cg25627403 chr19:41769009 HNRNPUL1 0.58 6.12 0.32 2.65e-9 Coronary artery disease; LUSC trans rs13390641 0.614 rs56169538 chr2:104086506 C/T cg03260781 chr1:16346299 HSPB7 -0.46 -6.09 -0.32 3.14e-9 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs11098499 0.821 rs3775852 chr4:120454556 A/G cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10387458 chr1:93645817 TMED5;CCDC18 -0.5 -6.32 -0.33 8.56e-10 Bipolar disorder and schizophrenia; LUSC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg09021430 chr5:549028 NA -0.56 -7.58 -0.38 3.52e-13 Obesity-related traits; LUSC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg06634786 chr22:41940651 POLR3H -0.47 -6.0 -0.31 5.16e-9 Vitiligo; LUSC cis rs41271473 0.950 rs72751907 chr1:228867648 C/T cg10167378 chr1:228756711 NA 0.58 6.96 0.36 1.77e-11 Chronic lymphocytic leukemia; LUSC cis rs6121246 0.567 rs6058189 chr20:30192389 A/G cg18721089 chr20:30220636 NA -0.41 -6.57 -0.34 1.93e-10 Mean corpuscular hemoglobin; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg10729496 chr3:10149963 C3orf24 0.57 7.66 0.39 2.08e-13 Alzheimer's disease; LUSC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg14895029 chr7:2775587 GNA12 -0.37 -5.68 -0.3 2.94e-8 Height; LUSC cis rs2573652 1.000 rs2581346 chr15:100514178 T/G cg09918751 chr15:100517450 ADAMTS17 -0.42 -7.71 -0.39 1.45e-13 Height; LUSC cis rs11676348 0.751 rs6715591 chr2:219019871 T/C cg00012203 chr2:219082015 ARPC2 -0.56 -8.87 -0.44 4.35e-17 Ulcerative colitis; LUSC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg17515076 chr17:73810948 UNK -0.39 -6.57 -0.34 1.92e-10 White matter hyperintensity burden; LUSC cis rs6001027 0.540 rs1005529 chr22:38541266 T/C cg25457927 chr22:38595422 NA -0.36 -7.17 -0.37 4.86e-12 Melanoma; LUSC cis rs599083 0.530 rs583545 chr11:68178635 T/C cg01657329 chr11:68192670 LRP5 0.48 6.32 0.33 8.42e-10 Bone mineral density (spine); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01801750 chr12:72148484 RAB21 -0.4 -5.97 -0.31 6.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2179367 0.537 rs12192159 chr6:149767105 C/A cg07828024 chr6:149772892 ZC3H12D -0.35 -5.84 -0.3 1.21e-8 Dupuytren's disease; LUSC cis rs6964587 0.869 rs55811257 chr7:91484799 T/A cg17063962 chr7:91808500 NA -0.48 -7.42 -0.38 9.81e-13 Breast cancer; LUSC cis rs72781680 1.000 rs17711825 chr2:24124578 A/G cg20701182 chr2:24300061 SF3B14 0.57 6.19 0.32 1.73e-9 Lymphocyte counts; LUSC cis rs28374715 0.578 rs17730589 chr15:41600878 T/C cg18705301 chr15:41695430 NDUFAF1 -1.04 -21.09 -0.76 2.22e-63 Ulcerative colitis; LUSC cis rs6901250 0.807 rs1606366 chr6:117132438 C/G cg12892004 chr6:117198278 RFX6 0.43 8.12 0.41 8.98e-15 C-reactive protein levels; LUSC cis rs57502260 0.704 rs2186937 chr11:68256847 G/A cg20283391 chr11:68216788 NA -0.63 -5.77 -0.3 1.83e-8 Total body bone mineral density (age 45-60); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg14331148 chr19:47551893 TMEM160 -0.35 -6.12 -0.32 2.62e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg23871527 chr20:2854169 PTPRA -0.42 -6.08 -0.32 3.37e-9 Electrocardiographic conduction measures; LUSC trans rs8073060 0.544 rs225249 chr17:33942540 T/C cg19694781 chr19:47549865 TMEM160 -1.14 -18.49 -0.71 4.69e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs9399135 0.967 rs6923765 chr6:135335176 C/G cg24558204 chr6:135376177 HBS1L -0.59 -9.23 -0.45 3.1e-18 Red blood cell count; LUSC cis rs7615316 0.779 rs6802631 chr3:142080583 G/T cg16271453 chr3:142027066 XRN1 -0.4 -6.99 -0.36 1.51e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6545883 0.894 rs6545867 chr2:61651027 C/T cg15711740 chr2:61764176 XPO1 0.43 6.55 0.34 2.13e-10 Tuberculosis; LUSC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg13939156 chr17:80058883 NA -0.33 -6.53 -0.34 2.5e-10 Life satisfaction; LUSC cis rs826838 0.967 rs826856 chr12:39115434 G/A cg26384229 chr12:38710491 ALG10B -0.83 -15.53 -0.65 2.62e-41 Heart rate; LUSC cis rs6445797 0.632 rs6802051 chr3:56670924 G/A cg13792233 chr3:56591045 CCDC66 0.41 5.72 0.3 2.33e-8 Gastritis; LUSC cis rs503341 0.756 rs480874 chr11:63591965 A/T cg04362095 chr11:63592001 C11orf84 -0.58 -8.9 -0.44 3.59e-17 Pulse pressure; LUSC cis rs2289583 0.544 rs12050759 chr15:75265191 G/A cg14664628 chr15:75095509 CSK 0.46 6.32 0.33 8.14e-10 Systemic lupus erythematosus; LUSC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg13206674 chr6:150067644 NUP43 0.56 8.67 0.43 1.95e-16 Lung cancer; LUSC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg25204440 chr1:209979598 IRF6 -0.5 -6.74 -0.35 6.9e-11 Cleft lip with or without cleft palate; LUSC cis rs3740713 0.669 rs34740438 chr11:18415330 C/A cg23797887 chr11:18477753 LDHAL6A -0.47 -5.67 -0.3 3.1e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7296418 0.699 rs1109559 chr12:123757861 C/T cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.14 -0.41 7.91e-15 Platelet count; LUSC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg16743903 chr16:89593216 SPG7 -0.39 -6.17 -0.32 1.93e-9 Multiple myeloma (IgH translocation); LUSC cis rs7107174 1.000 rs12277648 chr11:78054336 C/T cg02023728 chr11:77925099 USP35 0.44 6.72 0.35 7.74e-11 Testicular germ cell tumor; LUSC cis rs56283067 0.887 rs12215971 chr6:44784566 A/G cg18551225 chr6:44695536 NA -0.46 -7.11 -0.36 7.16e-12 Total body bone mineral density; LUSC cis rs8062405 0.755 rs4787456 chr16:28559573 C/T cg07382826 chr16:28625726 SULT1A1 0.28 5.81 0.3 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg08027265 chr7:2291960 NA -0.4 -6.64 -0.34 1.25e-10 Bipolar disorder and schizophrenia; LUSC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg18352616 chr4:3374830 RGS12 -0.33 -6.78 -0.35 5.57e-11 Serum sulfate level; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.66 9.93 0.48 1.52e-20 Lymphocyte counts; LUSC cis rs2486288 0.656 rs11637838 chr15:45550657 A/G cg09092052 chr15:45571596 NA 0.46 6.51 0.34 2.84e-10 Glomerular filtration rate; LUSC cis rs4906332 1.000 rs12896612 chr14:103877868 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -6.92 -0.35 2.31e-11 Coronary artery disease; LUSC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg19774624 chr17:42201019 HDAC5 0.72 10.53 0.5 1.36e-22 Total body bone mineral density; LUSC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.68 0.5 4.13e-23 Monocyte percentage of white cells; LUSC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.93 -13.1 -0.58 6.15e-32 Platelet count; LUSC cis rs9906944 0.707 rs9916472 chr17:47109998 C/T cg14634687 chr17:47094252 IGF2BP1 0.3 6.4 0.33 5.21e-10 Intelligence (multi-trait analysis);Body fat percentage; LUSC cis rs9457247 0.565 rs2038580 chr6:167456490 A/T cg07741184 chr6:167504864 NA 0.48 8.3 0.41 2.61e-15 Crohn's disease; LUSC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg19230755 chr7:65878503 NA 0.43 6.04 0.31 4.17e-9 Aortic root size; LUSC cis rs7267979 1.000 rs6050630 chr20:25430745 A/G cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7267979 1.000 rs2027003 chr20:25350498 A/G cg03522245 chr20:25566470 NINL -0.36 -5.8 -0.3 1.56e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2625529 0.529 rs7183055 chr15:72377048 C/T cg16672083 chr15:72433130 SENP8 0.49 8.12 0.41 9.35e-15 Red blood cell count; LUSC trans rs11098499 0.863 rs13140409 chr4:120503460 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.75 0.35 6.4e-11 Corneal astigmatism; LUSC cis rs7781370 0.921 rs4729260 chr7:96117918 G/C cg00604640 chr7:96133485 NA -0.34 -5.76 -0.3 1.9e-8 Bone mineral density (hip); LUSC cis rs3824488 0.765 rs10512247 chr9:98296403 C/T cg22073802 chr9:98269255 PTCH1 -0.46 -5.73 -0.3 2.29e-8 Neuroticism; LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs7572644 0.640 rs13027427 chr2:28021043 G/T cg27432699 chr2:27873401 GPN1 0.59 7.55 0.38 4.15e-13 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1577917 1.000 rs10944169 chr6:86683036 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.44e-15 Response to antipsychotic treatment; LUSC cis rs11608355 0.545 rs9943724 chr12:109902903 G/A cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg03676636 chr4:99064102 C4orf37 0.38 8.03 0.4 1.74e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs295140 0.585 rs4233996 chr2:201131228 A/T cg23649088 chr2:200775458 C2orf69 -0.4 -6.23 -0.32 1.38e-9 QT interval; LUSC cis rs748404 0.697 rs524547 chr15:43551023 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.99 0.31 5.3e-9 Lung cancer; LUSC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg19346786 chr7:2764209 NA -0.49 -8.11 -0.41 9.78e-15 Height; LUSC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs6500395 1.000 rs9925406 chr16:48671436 C/A cg04672837 chr16:48644449 N4BP1 0.46 6.92 0.35 2.37e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg02018176 chr4:1364513 KIAA1530 -0.66 -11.53 -0.53 4.16e-26 Obesity-related traits; LUSC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg06212747 chr3:49208901 KLHDC8B 0.6 8.31 0.41 2.36e-15 Menarche (age at onset); LUSC cis rs9326248 0.539 rs10892065 chr11:116897024 T/C cg20608306 chr11:116969690 SIK3 0.37 6.97 0.36 1.73e-11 Blood protein levels; LUSC cis rs7131987 0.650 rs11050187 chr12:29472876 T/C cg09582351 chr12:29534625 ERGIC2 -0.33 -6.68 -0.34 9.9e-11 QT interval; LUSC cis rs2798269 0.966 rs2093804 chr13:22138384 T/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.04 -0.31 4.15e-9 PR segment; LUSC cis rs1008375 0.900 rs4698625 chr4:17599500 G/T cg18681998 chr4:17616180 MED28 0.84 14.53 0.62 2.14e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs6502050 0.835 rs4789676 chr17:80123078 C/T cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs9549367 0.789 rs912012 chr13:113886152 G/A cg18105134 chr13:113819100 PROZ -0.71 -10.19 -0.49 2.1e-21 Platelet distribution width; LUSC cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.03 0.55 6.07e-28 Chronic sinus infection; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg11766577 chr21:47581405 C21orf56 -0.53 -8.21 -0.41 4.88e-15 Testicular germ cell tumor; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg24101359 chr6:42928495 GNMT 0.36 5.93 0.31 7.37e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2798269 1.000 rs12429479 chr13:22145941 C/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.94 -0.31 7.18e-9 PR segment; LUSC trans rs1941687 0.702 rs8090097 chr18:31413448 A/C cg27147174 chr7:100797783 AP1S1 -0.45 -6.82 -0.35 4.31e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs62400317 0.859 rs12201005 chr6:45136922 A/T cg20913747 chr6:44695427 NA -0.46 -7.49 -0.38 6.22e-13 Total body bone mineral density; LUSC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg18240062 chr17:79603768 NPLOC4 -0.79 -15.28 -0.64 2.35e-40 Eye color traits; LUSC trans rs6951245 1.000 rs78185801 chr7:1096367 G/A cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11039798 0.588 rs12294395 chr11:48476860 C/T cg15704280 chr7:45808275 SEPT13 0.63 6.66 0.34 1.16e-10 Axial length; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03468541 chr14:89029199 ZC3H14 0.55 9.43 0.46 7.18e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs501916 0.634 rs1561483 chr15:48069488 A/C cg16110827 chr15:48056943 SEMA6D -0.37 -5.67 -0.3 3.14e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg23034840 chr1:205782522 SLC41A1 -0.58 -8.23 -0.41 4.27e-15 Menarche (age at onset); LUSC cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg19628046 chr18:33552617 C18orf21 0.51 6.27 0.32 1.12e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6424115 0.965 rs2502979 chr1:24149315 C/A cg10978503 chr1:24200527 CNR2 0.49 11.46 0.53 6.97e-26 Immature fraction of reticulocytes; LUSC trans rs7618501 0.633 rs55751738 chr3:49972101 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.26 0.45 2.61e-18 Intelligence (multi-trait analysis); LUSC cis rs28785552 0.589 rs11669056 chr19:53244443 G/A cg22067481 chr19:53234126 ZNF611 -0.48 -6.33 -0.33 8.07e-10 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs11971779 0.585 rs3922848 chr7:139046210 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg07703079 chr11:430292 ANO9 0.6 6.31 0.33 8.81e-10 Body mass index; LUSC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg00310523 chr12:86230176 RASSF9 -0.42 -7.95 -0.4 2.83e-14 Major depressive disorder; LUSC cis rs17401966 0.838 rs4846197 chr1:10282166 G/A cg19773385 chr1:10388646 KIF1B -0.52 -8.84 -0.44 5.63e-17 Hepatocellular carcinoma; LUSC cis rs59698941 0.765 rs12163971 chr5:132226669 C/A cg02081065 chr5:132209139 LEAP2 -0.65 -6.75 -0.35 6.45e-11 Apolipoprotein A-IV levels; LUSC cis rs7927592 0.513 rs3853616 chr11:68198252 A/G cg16797656 chr11:68205561 LRP5 0.47 8.48 0.42 7.56e-16 Total body bone mineral density; LUSC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg08472276 chr7:1133186 C7orf50;GPER -0.34 -5.65 -0.3 3.4e-8 Longevity;Endometriosis; LUSC cis rs113835537 0.597 rs7939759 chr11:66337964 C/T cg24851651 chr11:66362959 CCS 0.58 9.04 0.44 1.28e-17 Airway imaging phenotypes; LUSC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg17366294 chr4:99064904 C4orf37 0.59 10.54 0.5 1.24e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1801251 1.000 rs56777991 chr2:233635388 A/C cg08000102 chr2:233561755 GIGYF2 0.7 11.73 0.54 7.36e-27 Coronary artery disease; LUSC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg26380479 chr7:97908229 NA -0.26 -5.86 -0.31 1.13e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg24596788 chr1:163392923 NA -0.44 -7.39 -0.38 1.15e-12 Motion sickness; LUSC cis rs2637266 0.538 rs2130800 chr10:78274818 C/T cg18941641 chr10:78392320 NA -0.34 -6.36 -0.33 6.6e-10 Pulmonary function; LUSC cis rs4319547 0.661 rs10773172 chr12:122939655 G/A cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.15 -0.41 7.63e-15 Body mass index; LUSC cis rs5769765 0.542 rs5770720 chr22:50253101 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.63 6.79 0.35 5e-11 Schizophrenia; LUSC cis rs4474465 0.646 rs10793335 chr11:78279005 C/G cg27205649 chr11:78285834 NARS2 0.56 6.82 0.35 4.31e-11 Alzheimer's disease (survival time); LUSC cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg16339924 chr4:17578868 LAP3 0.66 10.34 0.49 6.42e-22 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg07274523 chr3:49395745 GPX1 0.67 10.52 0.5 1.5e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6722750 0.905 rs10170666 chr2:64379672 G/A cg22352474 chr2:64371530 PELI1 0.73 11.59 0.54 2.54e-26 Neuroticism; LUSC trans rs2262909 0.962 rs55728714 chr19:22262899 A/G cg17074339 chr11:11642133 GALNTL4 0.48 7.3 0.37 2.13e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs3087591 0.708 rs2285894 chr17:29654876 T/A cg24425628 chr17:29625626 OMG;NF1 0.46 6.86 0.35 3.37e-11 Hip circumference; LUSC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12756686 chr19:29218302 NA 0.68 9.28 0.45 2.12e-18 Methadone dose in opioid dependence; LUSC cis rs4900538 0.855 rs1210074 chr14:102889098 G/A cg18135206 chr14:102964638 TECPR2 -0.99 -19.0 -0.72 4.38e-55 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs936229 0.784 rs12906946 chr15:75153140 A/G cg10253484 chr15:75165896 SCAMP2 -0.58 -7.83 -0.39 6.5e-14 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs72674100 1.000 rs7671134 chr4:97990088 A/G cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs4596713 0.538 rs10125494 chr9:71770861 C/G cg25283916 chr1:242222868 NA -0.31 -6.3 -0.33 9.33e-10 Headache; LUSC cis rs28830936 1.000 rs17678138 chr15:42043067 G/A cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.03 -0.31 4.33e-9 Diastolic blood pressure; LUSC cis rs394563 0.589 rs1900300 chr6:149641627 T/C cg07828024 chr6:149772892 ZC3H12D 0.33 7.15 0.36 5.37e-12 Dupuytren's disease; LUSC cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg22782873 chr19:19639568 YJEFN3 -0.47 -5.83 -0.3 1.34e-8 Bipolar disorder; LUSC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Tonsillectomy; LUSC cis rs8005677 1.000 rs2295685 chr14:23398153 A/G cg00579484 chr14:23475993 C14orf93 0.39 5.77 0.3 1.85e-8 Cognitive ability (multi-trait analysis); LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg13047869 chr3:10149882 C3orf24 0.62 8.87 0.44 4.43e-17 Alzheimer's disease; LUSC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg03433033 chr1:76189801 ACADM 0.82 13.25 0.59 1.67e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4363385 0.693 rs76987906 chr1:152964530 A/G cg00922841 chr1:152955080 SPRR1A -0.43 -7.34 -0.37 1.62e-12 Inflammatory skin disease; LUSC trans rs6951245 0.872 rs11768486 chr7:1101290 C/A cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg24675658 chr1:53192096 ZYG11B -0.62 -9.53 -0.46 3.4e-19 Monocyte count; LUSC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg07777115 chr5:623756 CEP72 -0.45 -5.77 -0.3 1.79e-8 Obesity-related traits; LUSC cis rs4268898 0.662 rs72795832 chr2:24441855 C/A cg06627628 chr2:24431161 ITSN2 -0.87 -12.82 -0.57 7e-31 Asthma; LUSC cis rs826838 1.000 rs826838 chr12:39106731 C/T cg26384229 chr12:38710491 ALG10B -0.84 -15.93 -0.66 6.45e-43 Heart rate; LUSC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg15448220 chr1:150897856 SETDB1 0.44 6.36 0.33 6.63e-10 Melanoma; LUSC cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg01028140 chr2:1542097 TPO -0.4 -6.17 -0.32 1.95e-9 IgG glycosylation; LUSC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg03676636 chr4:99064102 C4orf37 0.36 7.99 0.4 2.18e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.67 -10.37 -0.49 5.05e-22 Body mass index (adult); LUSC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg10556349 chr10:835070 NA 0.57 6.4 0.33 5.2e-10 Eosinophil percentage of granulocytes; LUSC cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg06550200 chr5:1325588 CLPTM1L -0.64 -10.7 -0.51 3.46e-23 Lung cancer; LUSC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg02353165 chr6:42928485 GNMT 0.71 12.2 0.56 1.4e-28 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg24596788 chr1:163392923 NA 0.43 7.23 0.37 3.29e-12 Motion sickness; LUSC cis rs12541635 0.707 rs2099150 chr8:107109408 A/T cg10147462 chr8:107024639 NA -0.41 -7.14 -0.36 5.97e-12 Age of smoking initiation; LUSC cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.83 -0.54 3.32e-27 Chronic sinus infection; LUSC cis rs34779708 0.966 rs4934736 chr10:35496868 G/A cg03585969 chr10:35415529 CREM 0.64 9.48 0.46 5.01e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3847687 1.000 rs78233646 chr12:131520170 G/T cg25772418 chr12:131519998 GPR133 -0.28 -6.09 -0.32 3.04e-9 Longevity; LUSC cis rs983392 0.805 rs7926344 chr11:59962166 G/A cg24026212 chr11:59952134 MS4A6A -0.37 -6.27 -0.32 1.1e-9 Alzheimer's disease (late onset); LUSC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg09359103 chr1:154839909 KCNN3 -0.72 -16.65 -0.67 9.91e-46 Prostate cancer; LUSC cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg23711669 chr6:146136114 FBXO30 0.93 18.35 0.71 1.61e-52 Lobe attachment (rater-scored or self-reported); LUSC cis rs9473147 0.543 rs9349407 chr6:47453378 C/G cg02130027 chr6:47444894 CD2AP 0.36 5.69 0.3 2.78e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg07092213 chr7:1199455 ZFAND2A -0.66 -10.94 -0.51 5.26e-24 Longevity;Endometriosis; LUSC cis rs6580649 0.941 rs17122611 chr12:48458149 C/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.07 -0.32 3.47e-9 Lung cancer; LUSC cis rs611744 0.647 rs689275 chr8:109241822 T/C cg18478394 chr8:109455254 TTC35 0.41 6.28 0.32 1.06e-9 Dupuytren's disease; LUSC cis rs250677 0.958 rs43147 chr5:148417103 C/G cg12140854 chr5:148520817 ABLIM3 0.35 5.74 0.3 2.16e-8 Breast cancer; LUSC trans rs12637928 0.560 rs4682579 chr3:110153261 G/T cg17371621 chr15:61264283 RORA 0.36 6.13 0.32 2.51e-9 Neuroticism; LUSC trans rs7824557 0.527 rs2572449 chr8:11239137 A/G cg15556689 chr8:8085844 FLJ10661 0.46 7.28 0.37 2.47e-12 Retinal vascular caliber; LUSC cis rs662064 0.925 rs669701 chr1:10544725 A/G cg20482658 chr1:10539492 PEX14 -0.3 -6.33 -0.33 8.09e-10 Asthma; LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg22963979 chr7:1858916 MAD1L1 -0.47 -6.89 -0.35 2.72e-11 Bipolar disorder and schizophrenia; LUSC cis rs259282 0.524 rs4805006 chr19:33124136 G/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.79 12.73 0.57 1.6e-30 Schizophrenia; LUSC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg04944784 chr2:26401820 FAM59B -0.69 -9.77 -0.47 5.39e-20 Gut microbiome composition (summer); LUSC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg11764359 chr7:65958608 NA -0.69 -11.09 -0.52 1.5e-24 Aortic root size; LUSC cis rs240764 0.782 rs239235 chr6:101100528 A/G cg09795085 chr6:101329169 ASCC3 0.42 6.09 0.32 3.09e-9 Neuroticism; LUSC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg14019146 chr3:50243930 SLC38A3 -0.36 -8.03 -0.4 1.74e-14 Body mass index; LUSC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg13390004 chr1:15929781 NA 0.41 6.74 0.35 7.15e-11 Systolic blood pressure; LUSC cis rs3741151 0.686 rs12288753 chr11:73136261 A/T cg17517138 chr11:73019481 ARHGEF17 0.81 7.52 0.38 5.05e-13 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg16624210 chr5:671434 TPPP 0.5 6.47 0.33 3.58e-10 Obesity-related traits; LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.21 0.41 4.87e-15 Bipolar disorder; LUSC cis rs9611519 0.964 rs4820428 chr22:41537589 C/T cg13813247 chr22:41461852 NA 0.37 6.81 0.35 4.57e-11 Neuroticism; LUSC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg01879757 chr17:41196368 BRCA1 -0.49 -7.72 -0.39 1.37e-13 Menopause (age at onset); LUSC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18595196 chr3:52726726 GNL3;SNORD69 -0.29 -5.73 -0.3 2.2e-8 Bipolar disorder; LUSC cis rs7202877 0.572 rs8051611 chr16:75388933 C/T cg03315344 chr16:75512273 CHST6 0.45 6.63 0.34 1.32e-10 Type 2 diabetes;Type 1 diabetes; LUSC trans rs7647973 0.626 rs9830730 chr3:49675875 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.87 -0.35 3.22e-11 Menarche (age at onset); LUSC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg03790207 chr6:42947109 PEX6 -0.45 -6.74 -0.35 6.84e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7592578 0.882 rs16832765 chr2:191468762 T/C cg11845111 chr2:191398756 TMEM194B -0.88 -11.24 -0.52 4.35e-25 Diastolic blood pressure; LUSC cis rs61931739 0.824 rs406753 chr12:34117408 A/G cg06521331 chr12:34319734 NA -0.38 -6.38 -0.33 6.01e-10 Morning vs. evening chronotype; LUSC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg11905131 chr22:24372483 LOC391322 -0.44 -7.33 -0.37 1.77e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1005224 0.520 rs6574249 chr14:76087152 A/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.48 -5.92 -0.31 7.89e-9 Large artery stroke; LUSC cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.56 0.5 1.11e-22 Homoarginine levels; LUSC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.63 9.61 0.47 1.78e-19 Height; LUSC cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg05564831 chr3:52568323 NT5DC2 0.33 5.78 0.3 1.68e-8 Intelligence (multi-trait analysis); LUSC cis rs708547 0.697 rs67479587 chr4:57878884 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.64 0.39 2.31e-13 Response to bleomycin (chromatid breaks); LUSC cis rs62400317 0.762 rs62436369 chr6:44867539 C/G cg20913747 chr6:44695427 NA -0.48 -7.44 -0.38 8.79e-13 Total body bone mineral density; LUSC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg17252645 chr8:143867129 LY6D 0.38 6.62 0.34 1.45e-10 Urinary tract infection frequency; LUSC cis rs1965732 1.000 rs1965732 chr2:3709108 A/G cg19052272 chr2:3704530 ALLC -0.36 -6.82 -0.35 4.28e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg22333733 chr11:31391482 DNAJC24;DCDC1 0.48 6.85 0.35 3.63e-11 Calcium levels; LUSC cis rs9905704 0.681 rs8081247 chr17:56557837 G/A cg19466818 chr17:56409534 MIR142 0.35 6.3 0.33 9.47e-10 Testicular germ cell tumor; LUSC cis rs72634258 0.554 rs4908705 chr1:7926401 C/T cg00042356 chr1:8021962 PARK7 0.65 8.04 0.4 1.62e-14 Inflammatory bowel disease; LUSC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs9747201 0.962 rs6502062 chr17:80086177 T/G cg17462356 chr17:80056334 FASN 0.46 6.23 0.32 1.41e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11890956 chr21:40555474 PSMG1 -0.74 -11.17 -0.52 7.82e-25 Menarche (age at onset); LUSC trans rs7819412 0.645 rs10156356 chr8:11046209 T/C cg08975724 chr8:8085496 FLJ10661 -0.43 -6.01 -0.31 4.98e-9 Triglycerides; LUSC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg23034840 chr1:205782522 SLC41A1 0.62 8.81 0.43 6.94e-17 Menarche (age at onset); LUSC cis rs6964587 1.000 rs7784248 chr7:91758111 A/G cg17063962 chr7:91808500 NA 0.59 9.35 0.46 1.26e-18 Breast cancer; LUSC cis rs1801251 1.000 rs4517962 chr2:233578337 T/C cg08000102 chr2:233561755 GIGYF2 0.7 11.67 0.54 1.21e-26 Coronary artery disease; LUSC cis rs6681460 1.000 rs6670378 chr1:67126585 C/T cg02459107 chr1:67143332 SGIP1 0.48 9.02 0.44 1.49e-17 Presence of antiphospholipid antibodies; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17144760 chr11:27384507 CCDC34 0.51 7.41 0.38 1.01e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg08132940 chr7:1081526 C7orf50 -0.52 -6.27 -0.32 1.11e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -8.11 -0.41 9.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11229555 0.645 rs10466659 chr11:58190112 A/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs60154123 0.615 rs701943 chr1:210425727 A/G cg22029157 chr1:209979665 IRF6 -0.54 -6.37 -0.33 6.17e-10 Coronary artery disease; LUSC cis rs9393777 1.000 rs9393777 chr6:26942027 T/C cg09904177 chr6:26538194 HMGN4 -0.63 -6.27 -0.32 1.1e-9 Intelligence (multi-trait analysis); LUSC trans rs2832077 0.505 rs9305386 chr21:30386751 A/G cg14791747 chr16:20752902 THUMPD1 -0.7 -7.31 -0.37 2e-12 Cognitive test performance; LUSC cis rs66887589 0.777 rs4643791 chr4:120265619 A/G cg09307838 chr4:120376055 NA -0.46 -7.02 -0.36 1.27e-11 Diastolic blood pressure; LUSC trans rs9354352 0.967 rs9354351 chr6:66696271 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.64 9.19 0.45 4.34e-18 Initial pursuit acceleration in psychotic disorders; LUSC cis rs722599 0.639 rs12882676 chr14:75272433 A/G cg06637938 chr14:75390232 RPS6KL1 0.4 5.67 0.3 3.17e-8 IgG glycosylation; LUSC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg07636037 chr3:49044803 WDR6 1.05 19.18 0.72 8.03e-56 Parkinson's disease; LUSC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg08508325 chr11:3079039 CARS 0.5 13.05 0.58 9.38e-32 Longevity; LUSC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg24060327 chr5:131705240 SLC22A5 -0.52 -8.62 -0.43 2.72e-16 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02674562 chr19:17837854 MAP1S 0.45 6.13 0.32 2.52e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4566357 0.787 rs12475134 chr2:227880511 C/T cg11843606 chr2:227700838 RHBDD1 -0.52 -7.1 -0.36 7.77e-12 Coronary artery disease; LUSC cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg19077165 chr18:44547161 KATNAL2 0.44 6.54 0.34 2.25e-10 Personality dimensions; LUSC cis rs7481584 0.581 rs515481 chr11:3047184 A/G cg05729581 chr11:3078854 CARS 0.4 5.92 0.31 7.83e-9 Calcium levels; LUSC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.46 -0.38 7.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6464929 0.956 rs10272564 chr7:148705490 G/A cg23583168 chr7:148888333 NA 0.47 5.99 0.31 5.41e-9 Pediatric bone mineral content (hip); LUSC trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg15704280 chr7:45808275 SEPT13 0.73 8.26 0.41 3.44e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg14440974 chr22:39074834 NA -0.35 -5.84 -0.3 1.23e-8 Menopause (age at onset); LUSC cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg27432699 chr2:27873401 GPN1 -0.59 -8.88 -0.44 4.11e-17 Total body bone mineral density; LUSC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg23985595 chr17:80112537 CCDC57 -0.3 -5.81 -0.3 1.45e-8 Life satisfaction; LUSC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.49 -9.69 -0.47 9.78e-20 Monocyte percentage of white cells; LUSC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg24503407 chr1:205819492 PM20D1 0.9 16.94 0.68 6.93e-47 Menarche (age at onset); LUSC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.23 0.49 1.46e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg26116260 chr4:7069785 GRPEL1 1.15 18.04 0.7 2.86e-51 Monocyte percentage of white cells; LUSC cis rs4423214 1.000 rs12797951 chr11:71143266 G/T cg05163923 chr11:71159392 DHCR7 -0.69 -10.51 -0.5 1.61e-22 Vitamin D levels; LUSC trans rs4773505 0.839 rs2882189 chr13:90380864 A/T cg07142010 chr1:21901166 ALPL -0.3 -6.0 -0.31 5.2e-9 Loneliness (multivariate analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10181911 chr2:210867059 RPE 0.43 5.98 0.31 5.82e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.67e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg18681998 chr4:17616180 MED28 0.83 15.08 0.64 1.46e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2235649 0.703 rs2076428 chr16:1817768 T/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 0.49 6.33 0.33 7.7e-10 Blood metabolite levels; LUSC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg03929089 chr4:120376271 NA -0.99 -17.72 -0.7 5.35e-50 Coronary artery disease; LUSC cis rs11098499 0.954 rs17009122 chr4:120362403 G/A cg24375607 chr4:120327624 NA 0.79 11.87 0.54 2.34e-27 Corneal astigmatism; LUSC cis rs2820315 0.867 rs2819349 chr1:201885026 C/T cg10061532 chr1:201886748 LMOD1 0.28 6.41 0.33 5.09e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs11190604 1.000 rs10883505 chr10:102280772 C/T cg07080220 chr10:102295463 HIF1AN 0.7 9.4 0.46 8.73e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9644630 0.658 rs4427190 chr8:19321385 C/T cg06562184 chr8:19319451 CSGALNACT1 -0.5 -8.37 -0.42 1.57e-15 Oropharynx cancer; LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg21087160 chr19:2269166 OAZ1 -0.37 -6.01 -0.31 4.75e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg04756594 chr16:24857601 SLC5A11 -0.37 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs1949733 1.000 rs2688233 chr4:8491885 T/C cg11789530 chr4:8429930 ACOX3 0.61 9.47 0.46 5.23e-19 Response to antineoplastic agents; LUSC cis rs10465746 0.746 rs12749350 chr1:84456948 T/A cg10977910 chr1:84465055 TTLL7 0.43 6.28 0.32 1.08e-9 Obesity-related traits; LUSC cis rs9467773 1.000 rs6933176 chr6:26540178 G/A cg05738196 chr6:26577821 NA 0.81 15.89 0.66 9.79e-43 Intelligence (multi-trait analysis); LUSC trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg04842962 chr6:43655489 MRPS18A -1.05 -24.22 -0.8 1.54e-75 IgG glycosylation; LUSC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg21724239 chr8:58056113 NA 0.59 6.76 0.35 6.05e-11 Developmental language disorder (linguistic errors); LUSC cis rs11030122 0.702 rs17279635 chr11:3973083 A/C cg08557956 chr11:4115526 RRM1 0.47 6.04 0.31 4e-9 Mean platelet volume;Platelet distribution width; LUSC trans rs2243480 1.000 rs4718316 chr7:65648731 A/G cg10756647 chr7:56101905 PSPH -0.84 -8.42 -0.42 1.14e-15 Diabetic kidney disease; LUSC cis rs713477 1.000 rs28478984 chr14:55911326 C/A cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC trans rs35110281 0.782 rs7282933 chr21:45046988 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.54 0.53 3.8e-26 Mean corpuscular volume; LUSC cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg25258033 chr6:167368657 RNASET2 -0.45 -7.42 -0.38 9.84e-13 Crohn's disease; LUSC cis rs35995292 1.000 rs10266891 chr7:38914805 A/G cg19327137 chr7:38886074 VPS41 0.34 5.71 0.3 2.47e-8 Subjective well-being (multi-trait analysis); LUSC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg19592336 chr6:28129416 ZNF389 0.46 6.14 0.32 2.37e-9 Depression; LUSC cis rs8016982 1.000 rs12147118 chr14:81652975 A/C cg01989461 chr14:81687754 GTF2A1 -0.6 -9.16 -0.45 5.47e-18 Schizophrenia; LUSC cis rs929354 0.772 rs1182364 chr7:157017912 T/C cg17757837 chr7:157058334 UBE3C -0.82 -13.31 -0.59 1.01e-32 Body mass index; LUSC cis rs7582180 0.764 rs12712075 chr2:100924129 T/C cg08017756 chr2:100939284 LONRF2 -0.45 -8.44 -0.42 9.64e-16 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg22920501 chr2:26401640 FAM59B -0.74 -10.52 -0.5 1.46e-22 Gut microbiome composition (summer); LUSC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg15704280 chr7:45808275 SEPT13 -0.51 -7.14 -0.36 5.83e-12 HDL cholesterol; LUSC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.26e-12 Aortic root size; LUSC trans rs9886428 1.000 rs2059671 chr8:14116229 C/G cg19037007 chr20:741798 C20orf54 -0.39 -6.11 -0.32 2.77e-9 IgG glycosylation; LUSC cis rs4851254 0.618 rs7596359 chr2:100665274 T/G cg07810366 chr2:100720526 AFF3 -0.45 -5.95 -0.31 6.68e-9 Intelligence (multi-trait analysis); LUSC cis rs7843479 0.582 rs13439690 chr8:21778082 T/C cg17168535 chr8:21777572 XPO7 0.86 15.77 0.65 3.01e-42 Mean corpuscular volume; LUSC cis rs12594515 1.000 rs57299255 chr15:45996532 C/A cg19682013 chr15:45996608 NA 0.39 5.79 0.3 1.67e-8 Waist circumference;Weight; LUSC cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg05347473 chr6:146136440 FBXO30 0.43 7.47 0.38 6.89e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs377070 0.816 rs309404 chr4:123617741 A/T cg10495464 chr4:123653540 BBS12;LOC729338 -0.4 -5.98 -0.31 5.86e-9 Mosquito bite size; LUSC cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg23158103 chr7:148848205 ZNF398 -0.5 -8.21 -0.41 5.03e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs981844 0.922 rs75543972 chr4:154664792 G/C cg14289246 chr4:154710475 SFRP2 0.46 5.72 0.3 2.41e-8 Response to statins (LDL cholesterol change); LUSC trans rs11098499 0.738 rs72918577 chr4:120326701 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.24 0.32 1.32e-9 Corneal astigmatism; LUSC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg08470875 chr2:26401718 FAM59B -0.65 -8.92 -0.44 3.02e-17 Gut microbiome composition (summer); LUSC cis rs7605827 0.897 rs7590963 chr2:15527888 T/C cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.59e-17 Educational attainment (years of education); LUSC cis rs8072100 0.967 rs7219303 chr17:45737701 A/G cg25173405 chr17:45401733 C17orf57 0.37 5.89 0.31 9.67e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg13319975 chr6:146136371 FBXO30 -0.45 -6.77 -0.35 5.91e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs6977660 0.660 rs28663574 chr7:19816905 G/A cg05791153 chr7:19748676 TWISTNB 0.68 7.22 0.37 3.49e-12 Thyroid stimulating hormone; LUSC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg15445000 chr17:37608096 MED1 0.4 6.95 0.36 1.93e-11 Glomerular filtration rate (creatinine); LUSC cis rs7917772 0.560 rs729023 chr10:104341887 A/G cg05855489 chr10:104503620 C10orf26 0.47 7.24 0.37 3.07e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8017423 1.000 rs2184281 chr14:90685923 A/G cg14092571 chr14:90743983 NA 0.37 5.93 0.31 7.72e-9 Mortality in heart failure; LUSC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg11843238 chr5:131593191 PDLIM4 0.39 6.56 0.34 2.05e-10 Breast cancer; LUSC cis rs9487051 0.735 rs1260596 chr6:109519847 T/C cg01475377 chr6:109611718 NA -0.36 -6.11 -0.32 2.7e-9 Reticulocyte fraction of red cells; LUSC cis rs17270561 0.609 rs1892245 chr6:25764833 G/T cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg12927641 chr6:109611667 NA -0.43 -7.58 -0.38 3.46e-13 Reticulocyte fraction of red cells; LUSC cis rs9393777 0.623 rs7756567 chr6:26481642 T/G cg12292205 chr6:26970375 C6orf41 -0.63 -7.57 -0.38 3.72e-13 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg06454157 chr6:167490870 NA -0.24 -5.94 -0.31 7.24e-9 Crohn's disease; LUSC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg18512352 chr11:47633146 NA 0.48 9.71 0.47 8.44e-20 Subjective well-being; LUSC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg23985595 chr17:80112537 CCDC57 -0.3 -5.75 -0.3 2.05e-8 Life satisfaction; LUSC cis rs8078723 1.000 rs709592 chr17:38175553 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -7.02 -0.36 1.25e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg04414720 chr1:150670196 GOLPH3L 0.53 8.47 0.42 7.75e-16 Tonsillectomy; LUSC cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg01884057 chr2:25150051 NA 0.44 10.16 0.49 2.67e-21 Body mass index; LUSC cis rs9486719 1.000 rs2263192 chr6:96873037 C/G cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg22029157 chr1:209979665 IRF6 0.81 10.42 0.5 3.33e-22 Cleft lip with or without cleft palate; LUSC cis rs8062405 1.000 rs55719896 chr16:28846866 G/A cg09754948 chr16:28834200 ATXN2L 0.42 6.11 0.32 2.78e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg12826209 chr6:26865740 GUSBL1 0.74 6.4 0.33 5.23e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg24675658 chr1:53192096 ZYG11B 0.79 13.95 0.61 3.62e-35 Monocyte count; LUSC cis rs6977940 0.818 rs73033488 chr7:2908343 A/G cg19731401 chr7:2775893 GNA12 0.55 6.4 0.33 5.17e-10 White matter integrity; LUSC cis rs2656056 1 rs2656056 chr15:78722519 T/C cg18825076 chr15:78729989 IREB2 -0.45 -6.29 -0.33 9.84e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg04586622 chr2:25135609 ADCY3 0.43 9.07 0.44 1.01e-17 Body mass index; LUSC cis rs12541635 0.934 rs62527361 chr8:107021574 T/A cg10147462 chr8:107024639 NA 0.55 9.8 0.47 4.39e-20 Age of smoking initiation; LUSC cis rs9790314 0.690 rs1903423 chr3:160842252 A/G cg03342759 chr3:160939853 NMD3 -0.42 -6.85 -0.35 3.55e-11 Morning vs. evening chronotype; LUSC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg06740227 chr12:86229804 RASSF9 0.38 6.06 0.31 3.64e-9 Major depressive disorder; LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg18765753 chr7:1198926 ZFAND2A -0.41 -7.6 -0.38 3.11e-13 Longevity;Endometriosis; LUSC cis rs2406342 0.511 rs472676 chr18:74607924 C/T cg16472389 chr18:74514291 NA 0.46 6.84 0.35 3.78e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); LUSC cis rs4319547 0.656 rs6488951 chr12:122873928 A/G cg23029597 chr12:123009494 RSRC2 -0.75 -9.47 -0.46 5.19e-19 Body mass index; LUSC cis rs11098499 0.754 rs12509621 chr4:120249660 T/C cg09307838 chr4:120376055 NA 0.7 10.6 0.5 8.3e-23 Corneal astigmatism; LUSC cis rs9925964 0.967 rs4889620 chr16:31131174 G/A cg02466173 chr16:30829666 NA 0.34 6.16 0.32 2.05e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4443100 0.916 rs8139695 chr22:23373902 A/T cg21100191 chr22:23484243 RTDR1 -0.51 -6.19 -0.32 1.73e-9 Serum parathyroid hormone levels; LUSC cis rs35417517 1 rs35417517 chr7:91772730 CG/C cg17063962 chr7:91808500 NA 0.6 9.65 0.47 1.34e-19 Breast cancer; LUSC trans rs72674100 1.000 rs4308366 chr4:97972932 G/C cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg00677455 chr12:58241039 CTDSP2 -0.58 -7.87 -0.4 4.92e-14 Multiple sclerosis; LUSC trans rs1728785 1.000 rs4783656 chr16:68580722 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg09034736 chr1:150693464 HORMAD1 0.49 7.11 0.36 7.05e-12 Melanoma; LUSC cis rs6460942 0.908 rs78374554 chr7:12242285 G/A cg06484146 chr7:12443880 VWDE -0.59 -5.73 -0.3 2.25e-8 Coronary artery disease; LUSC trans rs7829975 0.623 rs7010753 chr8:8373956 A/G cg27411982 chr8:10470053 RP1L1 0.41 6.49 0.33 3.11e-10 Mood instability; LUSC trans rs208520 0.661 rs1776361 chr6:66822270 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -17.62 -0.69 1.39e-49 Exhaled nitric oxide output; LUSC cis rs6840360 0.593 rs1877186 chr4:152692418 C/G cg22705602 chr4:152727874 NA -0.39 -8.31 -0.41 2.49e-15 Intelligence (multi-trait analysis); LUSC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg22834771 chr12:69754056 YEATS4 -0.54 -8.08 -0.4 1.23e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs34779708 0.966 rs7070427 chr10:35485689 A/T cg03585969 chr10:35415529 CREM 0.64 9.55 0.46 2.91e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg17554472 chr22:41940697 POLR3H -0.49 -5.86 -0.31 1.14e-8 Vitiligo; LUSC cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg22117172 chr7:91764530 CYP51A1 0.33 5.85 0.3 1.18e-8 Breast cancer; LUSC trans rs10802346 0.545 rs10924545 chr1:246364592 C/T cg13514129 chr1:39547527 MACF1 -0.71 -11.89 -0.55 1.99e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs4478858 0.735 rs12563669 chr1:31858067 A/G cg00250761 chr1:31883323 NA -0.31 -7.17 -0.37 4.9e-12 Alcohol dependence; LUSC cis rs7927771 0.524 rs7107922 chr11:47669289 C/A cg20307385 chr11:47447363 PSMC3 0.44 6.46 0.33 3.71e-10 Subjective well-being; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06936779 chr1:151171405 PIP5K1A -0.5 -6.44 -0.33 4.08e-10 Bipolar disorder and schizophrenia; LUSC cis rs1395 0.778 rs62128743 chr2:27390169 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.49 7.2 0.37 4.12e-12 Blood metabolite levels; LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.46 6.19 0.32 1.81e-9 Renal function-related traits (BUN); LUSC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg23649088 chr2:200775458 C2orf69 0.55 7.68 0.39 1.74e-13 Schizophrenia; LUSC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg16383222 chr8:145688536 CYHR1 0.33 5.75 0.3 2.06e-8 Age at first birth; LUSC cis rs7945718 0.934 rs11022478 chr11:12741104 T/C cg25843174 chr11:12811716 TEAD1 0.31 6.89 0.35 2.79e-11 Educational attainment (years of education); LUSC cis rs72634258 0.945 rs6577459 chr1:8100173 G/T cg00042356 chr1:8021962 PARK7 0.77 9.26 0.45 2.61e-18 Inflammatory bowel disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15504408 chr10:120101904 C10orf84 0.41 5.95 0.31 6.6e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg11244672 chr19:19639970 YJEFN3 -0.61 -7.59 -0.38 3.3e-13 Bipolar disorder; LUSC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg07936489 chr17:37558343 FBXL20 0.72 9.94 0.48 1.47e-20 Glomerular filtration rate (creatinine); LUSC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg20573242 chr4:122745356 CCNA2 0.65 9.5 0.46 4.14e-19 Type 2 diabetes; LUSC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg11663144 chr21:46675770 NA -0.4 -6.85 -0.35 3.59e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12134245 0.874 rs35115044 chr1:92021650 A/G cg25838465 chr1:92012736 NA -0.56 -10.12 -0.48 3.62e-21 Breast cancer; LUSC cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.39 0.33 5.53e-10 Rheumatoid arthritis; LUSC cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg15073853 chr19:18549131 ISYNA1 -0.31 -5.76 -0.3 1.96e-8 Breast cancer; LUSC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.75 0.35 6.47e-11 Tonsillectomy; LUSC trans rs853679 0.607 rs34661125 chr6:28281894 G/A cg06606381 chr12:133084897 FBRSL1 -0.92 -8.75 -0.43 1.06e-16 Depression; LUSC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14442939 chr10:27389572 ANKRD26 0.85 9.88 0.48 2.24e-20 Breast cancer; LUSC cis rs7149337 1.000 rs35567150 chr14:51725944 A/G cg23942311 chr14:51606299 NA 0.47 10.33 0.49 6.89e-22 Cancer; LUSC cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg23173402 chr1:227635558 NA 0.58 7.0 0.36 1.45e-11 Major depressive disorder; LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg25036284 chr2:26402008 FAM59B 0.72 9.54 0.46 3.19e-19 Gut microbiome composition (summer); LUSC cis rs9457247 0.602 rs4710175 chr6:167467800 A/G cg25258033 chr6:167368657 RNASET2 0.45 6.9 0.35 2.57e-11 Crohn's disease; LUSC cis rs9611565 0.559 rs8139993 chr22:41995335 T/C cg03806693 chr22:41940476 POLR3H -0.91 -12.72 -0.57 1.7e-30 Vitiligo; LUSC cis rs7927592 0.913 rs66752716 chr11:68273626 C/T cg20283391 chr11:68216788 NA -0.61 -8.55 -0.42 4.43e-16 Total body bone mineral density; LUSC cis rs9900062 1.000 rs11871616 chr17:62737602 C/T cg02598441 chr17:62777298 LOC146880 -0.7 -8.65 -0.43 2.17e-16 QT interval; LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg04546413 chr19:29218101 NA 0.73 13.09 0.58 7.01e-32 Methadone dose in opioid dependence; LUSC cis rs751728 0.687 rs9357164 chr6:33761021 T/C cg25922239 chr6:33757077 LEMD2 0.42 6.23 0.32 1.43e-9 Crohn's disease; LUSC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg05084668 chr3:125655381 ALG1L -0.51 -7.19 -0.37 4.35e-12 Blood pressure (smoking interaction); LUSC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg23649088 chr2:200775458 C2orf69 0.53 7.36 0.37 1.46e-12 Schizophrenia; LUSC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg05347473 chr6:146136440 FBXO30 -0.57 -9.83 -0.47 3.34e-20 Lobe attachment (rater-scored or self-reported); LUSC trans rs8002861 0.810 rs7334812 chr13:44445538 C/T cg12856521 chr11:46389249 DGKZ 0.44 6.9 0.35 2.62e-11 Leprosy; LUSC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg13206674 chr6:150067644 NUP43 0.55 8.04 0.4 1.57e-14 Lung cancer; LUSC trans rs372883 0.648 rs2832297 chr21:30742996 A/C cg14791747 chr16:20752902 THUMPD1 -0.45 -6.55 -0.34 2.15e-10 Pancreatic cancer; LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg10130564 chr11:117069849 TAGLN 0.37 6.31 0.33 8.86e-10 Blood protein levels; LUSC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg25019033 chr10:957182 NA -0.54 -6.87 -0.35 3.15e-11 Eosinophil percentage of granulocytes; LUSC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg17340268 chr14:105411764 AHNAK2 -0.39 -6.3 -0.33 9.59e-10 Rheumatoid arthritis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18247054 chr6:167369941 RNASET2 -0.41 -6.07 -0.32 3.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg00149659 chr3:10157352 C3orf10 0.89 12.15 0.55 2.18e-28 Alzheimer's disease; LUSC cis rs804280 0.509 rs13268030 chr8:11783073 C/T cg00405596 chr8:11794950 NA 0.36 5.98 0.31 5.72e-9 Myopia (pathological); LUSC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -7.06 -0.36 9.99e-12 Major depressive disorder; LUSC cis rs9672608 0.687 rs5019044 chr15:78796282 T/A cg18825076 chr15:78729989 IREB2 0.48 6.37 0.33 6.17e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg01475377 chr6:109611718 NA -0.42 -7.38 -0.37 1.27e-12 Reticulocyte fraction of red cells; LUSC cis rs7336332 0.628 rs9581854 chr13:28017782 C/T cg22138327 chr13:27999177 GTF3A 0.77 9.83 0.47 3.36e-20 Weight; LUSC cis rs9467773 0.620 rs2494716 chr6:26662736 T/C cg11502198 chr6:26597334 ABT1 0.73 12.23 0.56 1.17e-28 Intelligence (multi-trait analysis); LUSC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg25072359 chr17:41440525 NA 0.6 9.0 0.44 1.76e-17 Menopause (age at onset); LUSC cis rs793571 0.521 rs12594872 chr15:58912749 T/C cg05156742 chr15:59063176 FAM63B 0.46 6.96 0.36 1.86e-11 Schizophrenia; LUSC cis rs34115320 1 rs34115320 chr7:148783936 CT/C cg23583168 chr7:148888333 NA -0.8 -13.54 -0.6 1.3e-33 Sum basophil neutrophil counts;Neutrophil count; LUSC cis rs10751667 1.000 rs12798036 chr11:947585 T/C ch.11.42038R chr11:967971 AP2A2 0.54 8.2 0.41 5.14e-15 Alzheimer's disease (late onset); LUSC cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg03146154 chr1:46216737 IPP 0.51 7.27 0.37 2.61e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.07 0.4 1.27e-14 Axial length; LUSC cis rs7771547 0.573 rs629721 chr6:36398229 T/C cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC cis rs3858526 0.834 rs7129481 chr11:5991114 G/T cg02574844 chr11:5959923 NA -0.44 -6.02 -0.31 4.71e-9 DNA methylation (variation); LUSC cis rs10911232 0.507 rs4596846 chr1:182976034 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.55 0.5 1.21e-22 Hypertriglyceridemia; LUSC cis rs3087591 1.000 rs2854332 chr17:29712378 A/T cg24425628 chr17:29625626 OMG;NF1 -0.65 -9.45 -0.46 6.23e-19 Hip circumference; LUSC trans rs10432489 0.708 rs6730421 chr2:181755815 A/G cg09897338 chr1:211849090 NEK2 -0.77 -5.97 -0.31 6.21e-9 QT interval; LUSC cis rs11785400 0.793 rs2978973 chr8:143747271 C/G cg24634471 chr8:143751801 JRK 0.53 7.36 0.37 1.46e-12 Schizophrenia; LUSC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg25456477 chr12:86230367 RASSF9 0.33 5.78 0.3 1.68e-8 Major depressive disorder; LUSC cis rs11098499 0.754 rs7672372 chr4:120248406 A/G cg09307838 chr4:120376055 NA 0.71 10.73 0.51 2.88e-23 Corneal astigmatism; LUSC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg27284194 chr4:1044797 NA -0.35 -5.68 -0.3 2.93e-8 Obesity-related traits; LUSC cis rs911555 0.504 rs745079 chr14:104073551 G/A cg12935359 chr14:103987150 CKB -0.5 -7.75 -0.39 1.1e-13 Intelligence (multi-trait analysis); LUSC cis rs6543140 0.927 rs917999 chr2:103067869 G/A cg09003973 chr2:102972529 NA 0.51 6.61 0.34 1.53e-10 Blood protein levels; LUSC cis rs3806843 0.966 rs6891559 chr5:140145206 G/A cg19875535 chr5:140030758 IK 0.46 7.38 0.37 1.31e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs12893668 0.697 rs67899457 chr14:104060066 A/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -6.37 -0.33 6.44e-10 Reticulocyte count; LUSC cis rs2742234 0.955 rs2503865 chr10:43659536 C/T cg02780029 chr10:43622663 RET -0.35 -6.69 -0.34 9.32e-11 Hirschsprung disease; LUSC cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg03146154 chr1:46216737 IPP 0.52 7.79 0.39 8.3e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1997103 1.000 rs9649851 chr7:55398692 C/A cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg14004847 chr7:1930337 MAD1L1 -0.5 -7.33 -0.37 1.74e-12 Bipolar disorder and schizophrenia; LUSC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.0 -0.36 1.41e-11 Blood metabolite levels; LUSC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg18827107 chr12:86230957 RASSF9 -0.48 -6.96 -0.36 1.84e-11 Major depressive disorder; LUSC cis rs6714788 0.503 rs2309748 chr2:100681449 A/T cg22139774 chr2:100720529 AFF3 -0.39 -6.21 -0.32 1.61e-9 Intelligence (multi-trait analysis); LUSC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg04155289 chr7:94953770 PON1 -0.34 -5.75 -0.3 2.01e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs9463078 0.683 rs1342640 chr6:44743516 T/C cg25276700 chr6:44698697 NA 0.32 6.29 0.33 9.73e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg18876405 chr7:65276391 NA -0.55 -8.76 -0.43 9.78e-17 Aortic root size; LUSC cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg06092702 chr1:163392909 NA -0.47 -7.82 -0.39 7.14e-14 Motion sickness; LUSC cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg11244672 chr19:19639970 YJEFN3 -0.6 -7.18 -0.37 4.52e-12 Bipolar disorder; LUSC cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg07828340 chr4:882639 GAK 1.0 10.76 0.51 2.16e-23 Intelligence (multi-trait analysis); LUSC trans rs35110281 0.811 rs9980185 chr21:45057905 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.63 0.54 1.7e-26 Mean corpuscular volume; LUSC cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.12 -0.32 2.64e-9 Bipolar disorder; LUSC cis rs5769765 0.954 rs1569954 chr22:50244071 C/T cg26441486 chr22:50317300 CRELD2 -0.53 -8.01 -0.4 1.93e-14 Schizophrenia; LUSC cis rs662064 0.755 rs6667629 chr1:10524467 T/C cg20482658 chr1:10539492 PEX14 0.31 5.73 0.3 2.26e-8 Asthma; LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg20607798 chr8:58055168 NA 0.52 5.72 0.3 2.41e-8 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg17366294 chr4:99064904 C4orf37 0.57 9.9 0.48 2.03e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg17971929 chr21:40555470 PSMG1 0.79 13.88 0.6 6.93e-35 Cognitive function; LUSC cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg18132916 chr6:79620363 NA -0.39 -6.02 -0.31 4.68e-9 Intelligence (multi-trait analysis); LUSC cis rs9650657 0.683 rs7005905 chr8:10585144 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.48 0.33 3.22e-10 Neuroticism; LUSC cis rs2074977 0.550 rs11085020 chr19:3446107 C/T cg08380311 chr19:3435252 NFIC -0.65 -10.64 -0.5 5.79e-23 Height; LUSC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg27532560 chr4:187881888 NA -0.39 -6.41 -0.33 5.1e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.89 0.31 9.57e-9 Menopause (age at onset); LUSC cis rs9648716 0.515 rs1009772 chr7:140428000 A/G cg23214464 chr7:140373596 ADCK2 0.74 6.15 0.32 2.18e-9 Type 2 diabetes; LUSC cis rs11039100 0.607 rs2047462 chr11:5783948 C/A cg05234568 chr11:5960015 NA -0.43 -5.65 -0.3 3.38e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg24130564 chr14:104152367 KLC1 0.46 6.85 0.35 3.51e-11 Intelligence (multi-trait analysis); LUSC cis rs10843647 1.000 rs7300499 chr12:30323196 G/T cg12718339 chr12:29936407 TMTC1 -0.35 -5.77 -0.3 1.77e-8 Glucose homeostasis traits; LUSC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg18180107 chr4:99064573 C4orf37 0.42 5.77 0.3 1.77e-8 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.909 rs7659501 chr4:120371552 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg25809561 chr17:30822961 MYO1D -0.44 -7.39 -0.37 1.22e-12 Schizophrenia; LUSC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.45 6.13 0.32 2.53e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs4588572 0.537 rs7719228 chr5:77730576 G/A cg11547950 chr5:77652471 NA -0.48 -7.19 -0.37 4.18e-12 Triglycerides; LUSC cis rs9905704 0.836 rs170024 chr17:56831887 T/C cg12560992 chr17:57184187 TRIM37 0.58 8.32 0.41 2.29e-15 Testicular germ cell tumor; LUSC cis rs12594515 0.904 rs8032875 chr15:45998010 A/C cg01629716 chr15:45996671 NA 0.4 5.96 0.31 6.25e-9 Waist circumference;Weight; LUSC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg10792982 chr14:105748885 BRF1 0.48 8.68 0.43 1.75e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs2562456 0.833 rs8106025 chr19:21634724 A/C cg00806126 chr19:22604979 ZNF98 0.38 5.92 0.31 8.02e-9 Pain; LUSC cis rs6688613 0.685 rs10800276 chr1:166858941 A/G cg07049167 chr1:166818506 POGK -0.42 -6.31 -0.33 8.92e-10 Refractive astigmatism; LUSC cis rs763121 0.776 rs5757177 chr22:39007174 A/C cg14440974 chr22:39074834 NA -0.36 -5.91 -0.31 8.35e-9 Menopause (age at onset); LUSC cis rs11039100 0.850 rs11039117 chr11:5832464 G/A cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg23173402 chr1:227635558 NA 0.69 7.6 0.38 2.96e-13 Major depressive disorder; LUSC cis rs2274273 1.000 rs1047556 chr14:55600282 A/T cg04306507 chr14:55594613 LGALS3 0.53 11.37 0.53 1.48e-25 Protein biomarker; LUSC cis rs892961 0.932 rs9916143 chr17:75409282 C/G cg05865280 chr17:75406074 SEPT9 -0.47 -10.44 -0.5 2.96e-22 Airflow obstruction; LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg06145435 chr7:1022769 CYP2W1 0.29 6.38 0.33 5.99e-10 Longevity;Endometriosis; LUSC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.38 -0.33 5.89e-10 Extrinsic epigenetic age acceleration; LUSC cis rs6906287 0.573 rs12198461 chr6:118880640 T/G cg21191810 chr6:118973309 C6orf204 0.33 6.05 0.31 3.83e-9 Electrocardiographic conduction measures; LUSC cis rs35995292 0.963 rs2893567 chr7:38902934 A/G cg19327137 chr7:38886074 VPS41 0.34 5.79 0.3 1.66e-8 Subjective well-being (multi-trait analysis); LUSC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg15147215 chr3:52552868 STAB1 -0.32 -6.33 -0.33 7.76e-10 Electroencephalogram traits; LUSC cis rs617219 0.746 rs7724909 chr5:78559632 T/C cg24856658 chr5:78533917 JMY -0.31 -6.04 -0.31 4.22e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.13e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9925964 0.900 rs9934438 chr16:31104878 G/A cg02466173 chr16:30829666 NA 0.35 6.32 0.33 8.39e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4604732 0.588 rs4925551 chr1:247631724 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.87 0.35 3.13e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs422421 1.000 rs434434 chr5:176516953 A/G cg00618323 chr5:176515533 FGFR4 0.36 5.97 0.31 6.03e-9 Height; LUSC trans rs61931739 0.517 rs10772139 chr12:34186178 A/T cg13010199 chr12:38710504 ALG10B 0.55 8.48 0.42 7.46e-16 Morning vs. evening chronotype; LUSC cis rs6484504 0.576 rs58702363 chr11:31246397 C/A cg06552810 chr11:31128660 NA -0.4 -7.09 -0.36 8.26e-12 Red blood cell count; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg01125463 chr6:42946178 PEX6 -0.36 -6.02 -0.31 4.59e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg12826209 chr6:26865740 GUSBL1 0.76 9.22 0.45 3.51e-18 Intelligence (multi-trait analysis); LUSC trans rs1997103 1.000 rs6948112 chr7:55411302 G/A cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg26677194 chr12:130822605 PIWIL1 0.59 8.79 0.43 7.91e-17 Menopause (age at onset); LUSC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg17507749 chr15:85114479 UBE2QP1 0.68 8.55 0.42 4.36e-16 Schizophrenia; LUSC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 6.01 0.31 4.93e-9 Personality dimensions; LUSC cis rs9463078 0.845 rs6458419 chr6:45085038 T/C cg25276700 chr6:44698697 NA -0.28 -5.67 -0.3 3.04e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.43 -0.56 1.99e-29 Chronic sinus infection; LUSC cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg12386194 chr3:101231763 SENP7 0.63 8.59 0.43 3.44e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs12618769 1.000 rs72825727 chr2:99252750 G/C cg10123293 chr2:99228465 UNC50 0.43 5.93 0.31 7.49e-9 Bipolar disorder; LUSC cis rs2236918 1.000 rs2526704 chr1:242015820 A/G cg17736920 chr1:242011382 EXO1 0.44 6.82 0.35 4.24e-11 Menopause (age at onset); LUSC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg19592336 chr6:28129416 ZNF389 0.48 6.24 0.32 1.29e-9 Depression; LUSC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg25767906 chr1:53392781 SCP2 -0.62 -12.18 -0.55 1.78e-28 Monocyte count; LUSC cis rs9549260 0.564 rs4943808 chr13:41293950 C/T cg21288729 chr13:41239152 FOXO1 0.53 7.92 0.4 3.48e-14 Red blood cell count; LUSC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg01448562 chr3:133502909 NA -0.54 -7.94 -0.4 3.16e-14 Iron status biomarkers; LUSC cis rs7647973 0.577 rs6446247 chr3:49102001 A/T cg21141812 chr3:48556323 PFKFB4 0.37 6.22 0.32 1.46e-9 Menarche (age at onset); LUSC cis rs72829446 0.530 rs4796422 chr17:7380004 T/C cg02795151 chr17:7402630 POLR2A 0.61 7.4 0.38 1.13e-12 Androgen levels; LUSC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg16524733 chr11:117070046 TAGLN -0.44 -7.71 -0.39 1.44e-13 Blood protein levels; LUSC cis rs9309473 0.950 rs2947860 chr2:73855386 A/G cg20560298 chr2:73613845 ALMS1 -0.41 -5.87 -0.31 1.06e-8 Metabolite levels; LUSC cis rs11031096 0.655 rs10835736 chr11:4212013 G/A cg18678763 chr11:4115507 RRM1 -0.41 -5.72 -0.3 2.32e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7615952 1.000 rs7615952 chr3:125649403 A/C cg02807482 chr3:125708958 NA 0.48 5.85 0.31 1.15e-8 Blood pressure (smoking interaction); LUSC cis rs9549367 0.789 rs7338235 chr13:113888687 T/C cg00898013 chr13:113819073 PROZ -0.56 -8.09 -0.4 1.12e-14 Platelet distribution width; LUSC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg24549020 chr5:56110836 MAP3K1 0.49 6.2 0.32 1.64e-9 Initial pursuit acceleration; LUSC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg15445000 chr17:37608096 MED1 0.4 6.76 0.35 6.29e-11 Glomerular filtration rate (creatinine); LUSC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg21984481 chr17:79567631 NPLOC4 -0.69 -14.08 -0.61 1.09e-35 Eye color traits; LUSC cis rs4237845 0.513 rs7134797 chr12:58263852 C/T cg02175503 chr12:58329896 NA 0.48 6.84 0.35 3.74e-11 Intelligence (multi-trait analysis); LUSC cis rs9902453 0.934 rs12453172 chr17:28441590 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.14 0.41 7.79e-15 Coffee consumption (cups per day); LUSC cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg06108461 chr20:60628389 TAF4 -0.93 -15.59 -0.65 1.53e-41 Body mass index; LUSC cis rs6496667 0.683 rs1869180 chr15:90895467 T/C cg03599575 chr15:90893182 GABARAPL3 0.35 5.71 0.3 2.46e-8 Rheumatoid arthritis; LUSC cis rs12618769 0.656 rs3820943 chr2:99123177 G/C cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs17253792 0.822 rs17253730 chr14:56157911 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.93 -0.35 2.24e-11 Putamen volume; LUSC cis rs66887589 0.616 rs1052633 chr4:120215314 A/G cg09307838 chr4:120376055 NA 0.53 7.92 0.4 3.64e-14 Diastolic blood pressure; LUSC trans rs3733585 0.534 rs7375642 chr4:9955236 A/G cg26043149 chr18:55253948 FECH -0.45 -6.99 -0.36 1.49e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg18252515 chr7:66147081 NA 1.26 14.54 0.62 1.94e-37 Gout; LUSC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.33 -0.41 2.18e-15 Developmental language disorder (linguistic errors); LUSC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.65 -0.3 3.35e-8 Life satisfaction; LUSC cis rs1577917 0.917 rs2218594 chr6:86543766 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.9 -0.35 2.69e-11 Response to antipsychotic treatment; LUSC cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg18132916 chr6:79620363 NA -0.4 -6.08 -0.32 3.29e-9 Intelligence (multi-trait analysis); LUSC cis rs9807989 0.811 rs4485584 chr2:102970750 T/C cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs10876993 0.890 rs12302350 chr12:58062589 T/G cg15848620 chr12:58087721 OS9 -0.54 -7.71 -0.39 1.47e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg18301423 chr5:131593218 PDLIM4 0.43 6.73 0.35 7.46e-11 Blood metabolite levels; LUSC cis rs4704187 0.506 rs3935470 chr5:74352180 A/G cg03227963 chr5:74354835 NA 0.31 6.99 0.36 1.5e-11 Response to amphetamines; LUSC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg24733560 chr20:60626293 TAF4 0.41 6.77 0.35 5.69e-11 Body mass index; LUSC cis rs36093844 0.706 rs1445503 chr11:85585011 G/A cg25872744 chr11:85566296 CCDC83 -0.46 -6.0 -0.31 5.07e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg11663144 chr21:46675770 NA -0.41 -7.23 -0.37 3.33e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4343996 0.543 rs2140114 chr7:3407568 C/T cg21248987 chr7:3385318 SDK1 0.36 6.02 0.31 4.64e-9 Motion sickness; LUSC cis rs7589342 0.839 rs6747023 chr2:106431856 A/G cg16077055 chr2:106428750 NCK2 0.38 7.2 0.37 4.02e-12 Addiction; LUSC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg05347473 chr6:146136440 FBXO30 0.54 9.03 0.44 1.44e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg11764359 chr7:65958608 NA -0.58 -8.91 -0.44 3.26e-17 Aortic root size; LUSC cis rs11098499 0.909 rs28668716 chr4:120309875 T/C cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs68170813 0.559 rs12532967 chr7:106937418 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.65 -0.3 3.5e-8 Coronary artery disease; LUSC cis rs1775715 0.835 rs12266771 chr10:32231380 G/A cg04359828 chr10:32216031 ARHGAP12 0.38 6.44 0.33 4.26e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.78 0.35 5.49e-11 Rheumatoid arthritis; LUSC cis rs9902453 0.904 rs9905638 chr17:28261022 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.79 0.51 1.7e-23 Coffee consumption (cups per day); LUSC cis rs9925964 0.967 rs1549293 chr16:31141993 C/T cg02466173 chr16:30829666 NA 0.33 6.06 0.31 3.7e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs193541 0.626 rs6862779 chr5:122087282 C/T cg19077854 chr5:122220652 SNX24 0.28 6.21 0.32 1.59e-9 Glucose homeostasis traits; LUSC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg12463550 chr7:65579703 CRCP -0.46 -6.82 -0.35 4.21e-11 Aortic root size; LUSC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg09035930 chr12:129282057 SLC15A4 0.67 13.48 0.59 2.31e-33 Systemic lupus erythematosus; LUSC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23396286 chr10:99258505 UBTD1;MMS19 0.45 6.67 0.34 1.06e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg21226059 chr5:178986404 RUFY1 0.7 13.44 0.59 3.24e-33 Lung cancer; LUSC cis rs11098499 0.863 rs3775847 chr4:120447642 A/C cg09307838 chr4:120376055 NA 0.73 10.22 0.49 1.58e-21 Corneal astigmatism; LUSC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg17366294 chr4:99064904 C4orf37 0.59 10.64 0.5 5.96e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.13 0.41 8.64e-15 Bipolar disorder; LUSC cis rs7119167 0.901 rs10047442 chr11:73186864 A/T cg17517138 chr11:73019481 ARHGEF17 0.49 5.81 0.3 1.47e-8 Blood protein levels; LUSC cis rs35146811 0.735 rs7811662 chr7:99792608 A/G cg22906224 chr7:99728672 NA 0.47 6.58 0.34 1.86e-10 Coronary artery disease; LUSC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg01879757 chr17:41196368 BRCA1 -0.42 -6.54 -0.34 2.36e-10 Menopause (age at onset); LUSC cis rs611744 0.506 rs13280454 chr8:109263240 A/G cg21045802 chr8:109455806 TTC35 0.43 6.65 0.34 1.18e-10 Dupuytren's disease; LUSC cis rs225245 0.817 rs1476553 chr17:33994566 C/T cg05299278 chr17:33885742 SLFN14 0.28 6.14 0.32 2.41e-9 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg00779328 chr1:33745989 ZNF362 -0.4 -6.04 -0.31 4.17e-9 N-glycan levels; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs6831352 0.879 rs1984362 chr4:100070973 G/A cg12011299 chr4:100065546 ADH4 -0.72 -10.42 -0.5 3.31e-22 Alcohol dependence; LUSC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.46 0.5 2.43e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg22907277 chr7:1156413 C7orf50 0.6 9.37 0.46 1.14e-18 Longevity;Endometriosis; LUSC trans rs1945213 0.694 rs34537090 chr11:55843285 G/C cg15704280 chr7:45808275 SEPT13 0.73 8.41 0.42 1.21e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.24 0.37 3.09e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7177699 0.557 rs7165075 chr15:79115965 G/A cg00540400 chr15:79124168 NA 0.46 8.1 0.41 1.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4820539 0.934 rs3788351 chr22:23469181 T/C cg21100191 chr22:23484243 RTDR1 0.91 15.12 0.64 9.94e-40 Bone mineral density; LUSC cis rs8060686 0.641 rs75297764 chr16:68212820 C/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg00484396 chr16:3507460 NAT15 -0.48 -7.95 -0.4 2.98e-14 Body mass index (adult); LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg26304593 chr6:42947056 PEX6 0.52 8.23 0.41 4.24e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12760731 0.720 rs10913560 chr1:178452629 A/G cg00404053 chr1:178313656 RASAL2 0.68 7.5 0.38 5.94e-13 Obesity-related traits; LUSC cis rs1044826 0.692 rs184155 chr3:139229772 G/A cg15131784 chr3:139108705 COPB2 -0.4 -6.42 -0.33 4.62e-10 Obesity-related traits; LUSC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg04369109 chr6:150039330 LATS1 -0.57 -8.47 -0.42 8.03e-16 Lung cancer; LUSC cis rs1559088 0.847 rs8100392 chr19:33605933 T/C cg27124370 chr19:33622961 WDR88 0.57 7.37 0.37 1.37e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9902453 0.933 rs7216494 chr17:28502651 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.8 0.39 8.05e-14 Coffee consumption (cups per day); LUSC cis rs7180079 1.000 rs77627789 chr15:64444276 G/C cg02848875 chr15:64387786 SNX1 -0.5 -6.4 -0.33 5.26e-10 Monocyte count; LUSC cis rs7937682 0.924 rs513425 chr11:111504861 C/T cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg04352962 chr1:209979756 IRF6 0.52 6.96 0.36 1.86e-11 Cleft lip with or without cleft palate; LUSC cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg03146154 chr1:46216737 IPP -0.58 -8.42 -0.42 1.11e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1413885 0.516 rs9326063 chr1:65835911 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.49 7.09 0.36 7.85e-12 Anticoagulant levels; LUSC cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg13319975 chr6:146136371 FBXO30 -0.47 -6.92 -0.35 2.38e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs561341 1.000 rs550923 chr17:30327013 G/C cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg13047869 chr3:10149882 C3orf24 0.43 6.39 0.33 5.61e-10 Alzheimer's disease; LUSC cis rs865483 0.929 rs8064314 chr17:35858392 A/G cg06716730 chr17:35851459 DUSP14 0.28 6.38 0.33 5.92e-10 Monocyte count; LUSC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.83 15.27 0.64 2.72e-40 Total body bone mineral density; LUSC cis rs4820539 1.000 rs4822360 chr22:23482460 A/G cg14186256 chr22:23484241 RTDR1 0.91 16.67 0.67 8.11e-46 Bone mineral density; LUSC cis rs2239815 0.515 rs9625591 chr22:29232564 A/G cg02153584 chr22:29168773 CCDC117 0.52 6.0 0.31 5.14e-9 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs240764 0.645 rs240111 chr6:101059499 C/A cg09795085 chr6:101329169 ASCC3 0.4 5.81 0.3 1.48e-8 Neuroticism; LUSC cis rs1712517 0.740 rs4917387 chr10:105108455 T/C cg05636881 chr10:105038444 INA 0.4 6.74 0.35 7.11e-11 Migraine; LUSC cis rs7202877 0.572 rs4888371 chr16:75308781 G/A cg03315344 chr16:75512273 CHST6 0.43 6.43 0.33 4.44e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9653442 0.564 rs4851261 chr2:100786717 A/G cg07810366 chr2:100720526 AFF3 -0.44 -7.49 -0.38 6.12e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg14552801 chr7:65878734 NA -0.45 -6.35 -0.33 6.96e-10 Aortic root size; LUSC cis rs870825 0.929 rs72689266 chr4:185591053 T/C cg04058563 chr4:185651563 MLF1IP 0.83 11.29 0.53 2.87e-25 Blood protein levels; LUSC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7914558 1.000 rs1926030 chr10:104855656 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.15 -0.36 5.61e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6835098 1.000 rs4561909 chr4:174086937 A/T cg08422745 chr4:174089978 GALNT7 -0.76 -12.33 -0.56 4.73e-29 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs1055129 0.560 rs3682 chr17:73942150 A/G cg17515076 chr17:73810948 UNK -0.39 -6.47 -0.33 3.54e-10 White matter hyperintensity burden; LUSC cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg08754478 chr10:133766260 PPP2R2D -0.61 -7.79 -0.39 8.52e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs17092148 0.945 rs6087622 chr20:33310471 A/G cg16810054 chr20:33298113 TP53INP2 -0.39 -6.21 -0.32 1.53e-9 Neuroticism; LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs4666002 0.789 rs13023094 chr2:27910706 G/T cg27432699 chr2:27873401 GPN1 -0.51 -6.98 -0.36 1.56e-11 Phospholipid levels (plasma); LUSC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg03289416 chr15:75166202 SCAMP2 0.45 7.11 0.36 7.17e-12 Breast cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg05828906 chr6:126278519 HINT3 -0.44 -6.03 -0.31 4.37e-9 Hepatitis; LUSC cis rs2439831 0.867 rs8041132 chr15:43635136 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.06 13.19 0.59 2.77e-32 Lung cancer in ever smokers; LUSC cis rs3087591 0.960 rs2905880 chr17:29546175 A/G cg24425628 chr17:29625626 OMG;NF1 0.56 8.24 0.41 3.92e-15 Hip circumference; LUSC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg05110241 chr16:68378359 PRMT7 -0.57 -6.57 -0.34 1.89e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7954584 0.626 rs12809676 chr12:122442381 C/A cg21016266 chr12:122356598 WDR66 0.58 8.43 0.42 1.04e-15 Mean corpuscular volume; LUSC cis rs1348850 0.831 rs1345139 chr2:178449791 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.17 0.32 1.96e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2070433 0.851 rs1029231 chr21:47931653 A/G cg12379764 chr21:47803548 PCNT 0.7 9.23 0.45 3.29e-18 Lymphocyte counts; LUSC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg21862992 chr11:68658383 NA 0.51 8.19 0.41 5.71e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs3806843 1.000 rs4451093 chr5:140158542 A/G cg19875535 chr5:140030758 IK -0.5 -8.23 -0.41 4.37e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs60154123 0.614 rs628423 chr1:210460137 C/T cg22029157 chr1:209979665 IRF6 0.52 5.93 0.31 7.46e-9 Coronary artery disease; LUSC cis rs11166629 1.000 rs4909331 chr8:135644540 T/C cg21672855 chr8:135614777 ZFAT 0.36 5.84 0.3 1.26e-8 Smoking quantity; LUSC cis rs7927771 0.725 rs11570094 chr11:47359706 A/C cg05585544 chr11:47624801 NA 0.41 6.61 0.34 1.54e-10 Subjective well-being; LUSC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg13047869 chr3:10149882 C3orf24 0.66 9.61 0.47 1.79e-19 Alzheimer's disease; LUSC cis rs6546886 0.957 rs28450901 chr2:74252382 C/G cg14702570 chr2:74259524 NA -0.31 -5.86 -0.31 1.09e-8 Dialysis-related mortality; LUSC cis rs1799949 0.602 rs8176199 chr17:41230524 T/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 5.68 0.3 2.97e-8 Menopause (age at onset); LUSC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg06238570 chr21:40685208 BRWD1 0.49 7.43 0.38 9.13e-13 Cognitive function; LUSC cis rs9399135 0.967 rs12526055 chr6:135325918 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.17 0.45 4.93e-18 Red blood cell count; LUSC cis rs13089785 1.000 rs13092912 chr3:123604942 C/T cg01860459 chr3:123419554 MYLK 0.34 5.7 0.3 2.64e-8 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.778 rs4955546 chr3:134334738 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.79 -12.77 -0.57 1.1e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs7937682 0.883 rs510388 chr11:111451869 G/T cg18187862 chr3:45730750 SACM1L -0.52 -6.72 -0.35 7.81e-11 Primary sclerosing cholangitis; LUSC trans rs62238980 0.614 rs78247456 chr22:32442531 G/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs6430585 0.583 rs59243420 chr2:136584538 A/T cg07169764 chr2:136633963 MCM6 1.2 18.29 0.71 3.01e-52 Corneal structure; LUSC cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.92 0.7 8.72e-51 Chronic sinus infection; LUSC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg03351412 chr1:154909251 PMVK 0.54 8.6 0.43 3.1e-16 Prostate cancer; LUSC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.92e-14 Major depressive disorder; LUSC cis rs7131987 0.868 rs7958210 chr12:29395181 G/C cg09582351 chr12:29534625 ERGIC2 -0.32 -6.69 -0.34 9.32e-11 QT interval; LUSC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.67 14.66 0.63 6.6e-38 Hemoglobin concentration; LUSC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg22800045 chr5:56110881 MAP3K1 0.72 8.9 0.44 3.68e-17 Initial pursuit acceleration; LUSC trans rs1997103 1.000 rs7779040 chr7:55412947 T/C cg20935933 chr6:143382018 AIG1 0.51 7.38 0.37 1.26e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9398803 0.865 rs9388494 chr6:126776094 G/T cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.9e-9 Male-pattern baldness; LUSC cis rs8062405 0.723 rs12445744 chr16:28588395 A/C cg07382826 chr16:28625726 SULT1A1 0.28 5.97 0.31 6.13e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2282300 0.739 rs35229181 chr11:30241698 A/G cg25418670 chr11:30344373 C11orf46 -0.66 -9.53 -0.46 3.4e-19 Morning vs. evening chronotype; LUSC cis rs9677476 0.863 rs5018532 chr2:232077075 A/G cg07929768 chr2:232055508 NA 0.35 6.78 0.35 5.51e-11 Food antigen IgG levels; LUSC cis rs57502260 0.790 rs7129320 chr11:68388220 G/A cg20283391 chr11:68216788 NA -0.6 -5.81 -0.3 1.46e-8 Total body bone mineral density (age 45-60); LUSC cis rs1003719 0.688 rs2000413 chr21:38539718 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -9.99 -0.48 1.02e-20 Eye color traits; LUSC cis rs9463078 0.605 rs13215618 chr6:44936568 A/G cg25276700 chr6:44698697 NA 0.29 6.06 0.31 3.65e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4629180 0.544 rs7595274 chr2:102140086 T/C cg04415270 chr2:102091202 RFX8 -0.43 -7.36 -0.37 1.47e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs6430585 0.583 rs3769001 chr2:136626078 A/G cg07169764 chr2:136633963 MCM6 1.24 19.67 0.73 9.29e-58 Corneal structure; LUSC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC cis rs6545883 0.894 rs2694643 chr2:61604383 A/G cg15711740 chr2:61764176 XPO1 -0.41 -6.08 -0.32 3.36e-9 Tuberculosis; LUSC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg11812906 chr14:75593930 NEK9 0.66 11.27 0.52 3.54e-25 Height; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg00945038 chr17:61921165 SMARCD2 0.54 9.41 0.46 8.24e-19 Prudent dietary pattern; LUSC cis rs9300255 0.739 rs11057210 chr12:123733799 A/G cg00376283 chr12:123451042 ABCB9 0.65 8.31 0.41 2.45e-15 Neutrophil percentage of white cells; LUSC cis rs6681460 0.649 rs1415974 chr1:67005503 C/T cg02459107 chr1:67143332 SGIP1 -0.36 -6.07 -0.32 3.43e-9 Presence of antiphospholipid antibodies; LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 7.04e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9479482 1.000 rs9478362 chr6:150340526 T/C cg25797454 chr6:150327115 RAET1K 0.37 8.56 0.42 4.17e-16 Alopecia areata; LUSC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg03609598 chr5:56110824 MAP3K1 -0.42 -6.25 -0.32 1.22e-9 Initial pursuit acceleration; LUSC cis rs5769765 0.542 rs738707 chr22:50250827 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.63 6.79 0.35 5e-11 Schizophrenia; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg01503640 chr19:18963027 UPF1 -0.4 -6.3 -0.33 9.49e-10 N-glycan levels; LUSC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg08213375 chr14:104286397 PPP1R13B 0.44 7.58 0.38 3.4e-13 Reticulocyte count; LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs6722750 0.716 rs2028149 chr2:64415259 A/G cg22352474 chr2:64371530 PELI1 -0.52 -7.69 -0.39 1.7e-13 Neuroticism; LUSC cis rs13385 0.769 rs34675890 chr5:139622272 T/C cg26211634 chr5:139558579 C5orf32 0.47 7.2 0.37 3.92e-12 Atrial fibrillation; LUSC cis rs3096299 0.967 rs2965830 chr16:89460290 T/C cg06640241 chr16:89574553 SPG7 0.73 11.87 0.54 2.44e-27 Multiple myeloma (IgH translocation); LUSC cis rs1003719 0.762 rs9975361 chr21:38450025 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.43 0.53 9.68e-26 Eye color traits; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg00149659 chr3:10157352 C3orf10 0.9 12.57 0.57 6.42e-30 Alzheimer's disease; LUSC trans rs7181230 0.885 rs2412478 chr15:40361172 C/T cg22705835 chr10:65332833 REEP3 -0.39 -6.5 -0.34 2.95e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg17971929 chr21:40555470 PSMG1 -0.61 -10.07 -0.48 5.14e-21 Cognitive function; LUSC cis rs377070 0.844 rs309415 chr4:123621228 C/T cg10495464 chr4:123653540 BBS12;LOC729338 0.42 6.34 0.33 7.57e-10 Mosquito bite size; LUSC cis rs877282 0.898 rs11253350 chr10:765968 G/A cg17470449 chr10:769945 NA 0.53 7.09 0.36 8.21e-12 Uric acid levels; LUSC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg00012203 chr2:219082015 ARPC2 -0.7 -11.59 -0.54 2.53e-26 Colorectal cancer; LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg01097406 chr16:89675127 NA 0.35 6.99 0.36 1.51e-11 Vitiligo; LUSC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.7 0.34 8.73e-11 Tonsillectomy; LUSC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.76 0.68 3.58e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9653442 0.564 rs11687586 chr2:100789346 A/G cg22139774 chr2:100720529 AFF3 -0.41 -7.04 -0.36 1.09e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.49 0.46 4.39e-19 Bipolar disorder; LUSC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg03351412 chr1:154909251 PMVK 0.49 7.54 0.38 4.55e-13 Prostate cancer; LUSC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg11062466 chr8:58055876 NA 0.67 7.98 0.4 2.36e-14 Developmental language disorder (linguistic errors); LUSC trans rs6951245 0.580 rs78894484 chr7:1138721 T/G cg13565492 chr6:43139072 SRF -0.73 -10.9 -0.51 7.13e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12618769 0.597 rs17031905 chr2:99070902 A/G cg10123293 chr2:99228465 UNC50 0.41 6.96 0.36 1.8e-11 Bipolar disorder; LUSC trans rs6502050 0.835 rs8080625 chr17:80115447 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs2282802 0.711 rs1864970 chr5:139633042 T/C cg26211634 chr5:139558579 C5orf32 0.44 8.13 0.41 8.41e-15 Intelligence (multi-trait analysis); LUSC cis rs17253792 0.822 rs75995456 chr14:56073194 A/G cg01858014 chr14:56050164 KTN1 -0.87 -6.95 -0.36 1.95e-11 Putamen volume; LUSC cis rs983392 0.709 rs7932740 chr11:59976111 G/A cg24026212 chr11:59952134 MS4A6A -0.36 -6.19 -0.32 1.74e-9 Alzheimer's disease (late onset); LUSC cis rs6918586 0.658 rs198830 chr6:26118246 T/A cg17691542 chr6:26056736 HIST1H1C 0.39 5.8 0.3 1.57e-8 Schizophrenia; LUSC cis rs2479724 1.000 rs2254479 chr6:41831143 G/A cg17623882 chr6:41773611 USP49 -0.63 -10.41 -0.5 3.52e-22 Menarche (age at onset); LUSC cis rs7580658 0.724 rs6712551 chr2:127998485 G/A cg09760422 chr2:128146352 NA -0.3 -6.79 -0.35 5.27e-11 Protein C levels; LUSC trans rs9860340 0.730 rs1509780 chr3:87642396 G/A cg03644585 chr7:884825 UNC84A 0.42 6.0 0.31 5.03e-9 Electroencephalographic traits in alcoholism; LUSC trans rs2797160 1.000 rs1739357 chr6:126019655 T/G cg05039488 chr6:79577232 IRAK1BP1 0.46 7.05 0.36 1.01e-11 Endometrial cancer; LUSC cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg00579200 chr11:133705235 NA -0.39 -5.67 -0.3 3.12e-8 Childhood ear infection; LUSC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg13390004 chr1:15929781 NA 0.42 6.95 0.36 1.92e-11 Systolic blood pressure; LUSC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.43 0.42 1.02e-15 Tonsillectomy; LUSC cis rs8141529 0.509 rs6005927 chr22:29255884 A/G cg15103426 chr22:29168792 CCDC117 0.5 6.47 0.33 3.44e-10 Lymphocyte counts; LUSC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg22535103 chr8:58192502 C8orf71 -0.73 -7.44 -0.38 8.49e-13 Developmental language disorder (linguistic errors); LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg12432903 chr7:1882776 MAD1L1 -0.51 -8.77 -0.43 9.05e-17 Bipolar disorder and schizophrenia; LUSC cis rs12819124 0.502 rs10875718 chr12:48411102 G/T cg21466736 chr12:48725269 NA -0.33 -6.08 -0.32 3.33e-9 Glycated hemoglobin levels; LUSC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg17644776 chr2:200775616 C2orf69 0.53 9.47 0.46 5.31e-19 Osteoporosis; LUSC cis rs10752881 1.000 rs10797811 chr1:182984432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.56 0.5 1.15e-22 Colorectal cancer; LUSC cis rs1595825 0.891 rs1851779 chr2:198647108 C/T cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 5.92e-9 Ulcerative colitis; LUSC cis rs11676348 0.710 rs11894169 chr2:219046846 T/C cg00012203 chr2:219082015 ARPC2 0.59 9.45 0.46 5.98e-19 Ulcerative colitis; LUSC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg12751644 chr20:60527061 NA -0.33 -5.86 -0.31 1.1e-8 Body mass index; LUSC trans rs10435719 0.780 rs9692662 chr8:11789863 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.05 0.31 3.84e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02968854 chr7:30518406 NOD1 -0.4 -5.96 -0.31 6.54e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1348850 0.519 rs10201883 chr2:178471407 T/C cg27490568 chr2:178487706 NA 0.48 6.31 0.33 8.92e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2652834 0.718 rs2729832 chr15:63396401 A/G cg05507819 chr15:63340323 TPM1 0.54 6.93 0.35 2.19e-11 HDL cholesterol; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg08088566 chr11:430123 ANO9 0.62 7.21 0.37 3.77e-12 Body mass index; LUSC cis rs6733011 0.578 rs4851171 chr2:99510817 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.4 -5.66 -0.3 3.18e-8 Bipolar disorder; LUSC cis rs12188164 0.932 rs2230437 chr5:476353 C/T cg26850624 chr5:429559 AHRR -0.42 -8.32 -0.41 2.32e-15 Cystic fibrosis severity; LUSC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.8 0.63 1.84e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.23 0.52 4.66e-25 Menopause (age at onset); LUSC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.58 8.24 0.41 4.06e-15 Alzheimer's disease; LUSC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg23172400 chr8:95962367 TP53INP1 -0.3 -5.71 -0.3 2.45e-8 Type 2 diabetes; LUSC cis rs17095355 1.000 rs72828232 chr10:111725298 C/T cg00817464 chr10:111662876 XPNPEP1 -0.66 -7.68 -0.39 1.75e-13 Biliary atresia; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg00945038 chr17:61921165 SMARCD2 0.54 9.52 0.46 3.65e-19 Prudent dietary pattern; LUSC cis rs7520050 0.807 rs5021934 chr1:46109304 A/G cg06784218 chr1:46089804 CCDC17 -0.3 -5.83 -0.3 1.31e-8 Red blood cell count;Reticulocyte count; LUSC trans rs11935423 0.778 rs11937107 chr4:100503761 C/T cg02164153 chr5:172068145 NEURL1B -0.47 -6.05 -0.31 3.97e-9 Gut microbiome composition (summer); LUSC cis rs909674 0.775 rs4821896 chr22:39833437 T/C cg11247378 chr22:39784982 NA -0.64 -11.42 -0.53 9.95e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs3126085 0.935 rs12726613 chr1:152185500 C/G cg03465714 chr1:152285911 FLG 0.42 5.88 0.31 1.02e-8 Atopic dermatitis; LUSC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.5 -0.34 2.94e-10 Alzheimer's disease (late onset); LUSC cis rs8017423 0.967 rs2149655 chr14:90707246 T/C cg04374321 chr14:90722782 PSMC1 0.73 11.55 0.53 3.52e-26 Mortality in heart failure; LUSC cis rs3936840 0.565 rs8011721 chr14:102986388 C/G cg18135206 chr14:102964638 TECPR2 -0.47 -6.29 -0.33 9.7e-10 Plateletcrit; LUSC cis rs2274273 0.686 rs68083077 chr14:55574428 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.61 0.47 1.87e-19 Protein biomarker; LUSC trans rs2549003 1.000 rs2070731 chr5:131819798 T/C cg07455318 chr14:91772383 CCDC88C 0.38 6.05 0.31 3.89e-9 Asthma (sex interaction); LUSC cis rs5167 0.566 rs35080293 chr19:45496624 T/G cg25746394 chr19:45450501 APOC2 0.32 6.07 0.32 3.55e-9 Blood protein levels; LUSC cis rs6951245 0.872 rs11768895 chr7:1063691 T/C cg22907277 chr7:1156413 C7orf50 0.55 5.96 0.31 6.42e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg23711669 chr6:146136114 FBXO30 -0.82 -14.5 -0.62 2.82e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs11122272 0.735 rs2808584 chr1:231512925 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.19 0.66 6.55e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.17 -0.32 2.02e-9 Platelet count; LUSC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg06481639 chr22:41940642 POLR3H 0.49 5.75 0.3 2.06e-8 Vitiligo; LUSC cis rs7582720 1.000 rs72926782 chr2:203811628 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9296092 0.538 rs9461887 chr6:33526827 C/T cg13560919 chr6:33536144 NA -0.85 -16.28 -0.67 2.73e-44 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7089973 0.604 rs35319791 chr10:116602296 C/A cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9952991 0.883 rs2847293 chr18:12782448 A/T cg23544223 chr18:12777786 NA 0.58 6.15 0.32 2.24e-9 Inflammatory skin disease; LUSC cis rs9788721 0.835 rs17487223 chr15:78923987 A/G cg18825076 chr15:78729989 IREB2 0.46 7.19 0.37 4.26e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs9660992 0.542 rs17345153 chr1:205179997 A/G cg00857998 chr1:205179979 DSTYK 0.67 10.59 0.5 8.52e-23 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1113500 0.524 rs12145813 chr1:108569904 C/T cg11967332 chr1:108735228 SLC25A24 0.41 5.72 0.3 2.31e-8 Growth-regulated protein alpha levels; LUSC cis rs977987 0.806 rs1895490 chr16:75392806 G/A cg04384234 chr16:75411784 CFDP1 -0.42 -6.87 -0.35 3.1e-11 Dupuytren's disease; LUSC cis rs7809950 0.817 rs34325395 chr7:107113808 C/G cg23024343 chr7:107201750 COG5 -0.69 -10.28 -0.49 1.05e-21 Coronary artery disease; LUSC cis rs4654899 0.772 rs7548269 chr1:21089472 T/C cg01072550 chr1:21505969 NA -0.47 -6.97 -0.36 1.67e-11 Superior frontal gyrus grey matter volume; LUSC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg16606324 chr3:10149918 C3orf24 0.44 7.01 0.36 1.36e-11 Alzheimer's disease; LUSC trans rs7824557 0.547 rs2736287 chr8:11228006 G/A cg06636001 chr8:8085503 FLJ10661 -0.43 -6.38 -0.33 5.98e-10 Retinal vascular caliber; LUSC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg18765753 chr7:1198926 ZFAND2A -0.35 -6.3 -0.33 9.6e-10 Longevity;Endometriosis; LUSC cis rs13720 0.722 rs163800 chr20:57578508 C/T cg23907860 chr20:57583709 CTSZ 0.47 6.23 0.32 1.37e-9 Platelet distribution width; LUSC cis rs7215564 0.908 rs2873059 chr17:78663874 T/C cg23238734 chr17:78661607 RPTOR 0.48 6.12 0.32 2.63e-9 Myopia (pathological); LUSC cis rs76878669 0.917 rs10444359 chr11:66102807 G/A cg18002602 chr11:66138449 SLC29A2 -0.38 -5.91 -0.31 8.64e-9 Educational attainment (years of education); LUSC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg14895029 chr7:2775587 GNA12 -0.39 -5.99 -0.31 5.43e-9 Height; LUSC cis rs10789491 0.953 rs11211337 chr1:47133811 T/C cg15501359 chr1:47185051 KIAA0494 0.83 11.69 0.54 1.03e-26 Response to hepatitis C treatment; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg15539395 chr19:59086703 MGC2752 0.47 6.42 0.33 4.78e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg05665937 chr4:1216051 CTBP1 -0.37 -5.89 -0.31 9.51e-9 Obesity-related traits; LUSC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg15541040 chr2:3486749 NA -0.58 -8.86 -0.44 4.81e-17 Neurofibrillary tangles; LUSC cis rs929354 0.772 rs1182432 chr7:157029176 A/G cg05182265 chr7:156933206 UBE3C -0.58 -9.58 -0.46 2.29e-19 Body mass index; LUSC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg03188948 chr7:1209495 NA 0.66 6.92 0.35 2.35e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2227930 0.506 rs13061409 chr3:142025340 G/A cg16271453 chr3:142027066 XRN1 -0.55 -9.89 -0.48 2.13e-20 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg08859206 chr1:53392774 SCP2 0.5 8.51 0.42 6.03e-16 Monocyte count; LUSC cis rs11158026 0.757 rs10150110 chr14:55462010 G/T cg04306507 chr14:55594613 LGALS3 0.36 7.02 0.36 1.23e-11 Parkinson's disease; LUSC cis rs7560272 0.538 rs4852976 chr2:73936322 T/C cg20560298 chr2:73613845 ALMS1 0.38 5.86 0.31 1.1e-8 Schizophrenia; LUSC cis rs3935685 0.934 rs61331678 chr15:77995949 G/C cg25212270 chr15:78015279 NA 0.28 6.17 0.32 1.95e-9 Intelligence (multi-trait analysis); LUSC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg06363034 chr20:62225388 GMEB2 -0.45 -7.62 -0.38 2.63e-13 Glioblastoma; LUSC trans rs72674100 0.867 rs28673828 chr4:97991632 T/C cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg21782813 chr7:2030301 MAD1L1 0.48 8.33 0.41 2.05e-15 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg08219700 chr8:58056026 NA 0.65 7.59 0.38 3.13e-13 Developmental language disorder (linguistic errors); LUSC cis rs10875746 0.951 rs4760690 chr12:48563653 G/A cg13454099 chr12:49076203 C12orf41 -0.5 -5.84 -0.3 1.25e-8 Longevity (90 years and older); LUSC cis rs4604732 0.578 rs112449432 chr1:247624180 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.42 6.11 0.32 2.85e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs2882667 0.690 rs160405 chr5:138084076 A/G cg04439458 chr5:138467593 SIL1 -0.4 -7.29 -0.37 2.21e-12 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs977987 0.806 rs4993969 chr16:75411521 A/T cg03315344 chr16:75512273 CHST6 0.48 9.54 0.46 3.1e-19 Dupuytren's disease; LUSC cis rs7772486 0.875 rs6570738 chr6:146412695 G/A cg23711669 chr6:146136114 FBXO30 0.83 14.52 0.62 2.22e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs7084402 1.000 rs1863665 chr10:60266640 T/C cg07615347 chr10:60278583 BICC1 -0.35 -5.76 -0.3 1.95e-8 Refractive error; LUSC cis rs1863824 0.502 rs11202058 chr10:88282611 G/A cg07322936 chr10:88137208 NA -0.58 -7.98 -0.4 2.29e-14 Schizophrenia; LUSC cis rs7973719 0.833 rs7970916 chr12:7357746 T/C cg07052231 chr12:7363540 PEX5 0.54 9.42 0.46 7.85e-19 IgG glycosylation; LUSC cis rs9527 0.590 rs7912517 chr10:104905529 G/A cg04362960 chr10:104952993 NT5C2 0.62 9.74 0.47 6.69e-20 Arsenic metabolism; LUSC trans rs11098499 0.865 rs28845498 chr4:120405186 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 4.01e-10 Corneal astigmatism; LUSC cis rs10791097 0.702 rs10894267 chr11:130714861 C/T cg12179176 chr11:130786555 SNX19 -0.68 -10.35 -0.49 5.84e-22 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg10909506 chr17:38081995 ORMDL3 0.35 6.16 0.32 2.11e-9 Self-reported allergy; LUSC cis rs11677416 1.000 rs2856841 chr2:113537339 A/G cg27083787 chr2:113543245 IL1A 0.48 7.39 0.37 1.21e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs9430161 0.611 rs2095920 chr1:11033457 T/A cg02454025 chr1:11042201 C1orf127 1.03 18.67 0.71 8.68e-54 Ewing sarcoma; LUSC cis rs72772090 0.539 rs10515248 chr5:96112005 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -7.27 -0.37 2.59e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg02772935 chr3:125709198 NA -0.47 -5.71 -0.3 2.44e-8 Blood pressure (smoking interaction); LUSC cis rs11250098 0.548 rs7843470 chr8:10784492 C/G cg27411982 chr8:10470053 RP1L1 -0.45 -6.56 -0.34 2.05e-10 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11158959 chr15:65102290 NA -0.41 -6.1 -0.32 2.9e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs5769765 0.740 rs2103932 chr22:50272515 A/G cg04176532 chr22:50317003 CRELD2 -0.4 -5.76 -0.3 1.92e-8 Schizophrenia; LUSC trans rs9393777 0.777 rs35984974 chr6:27410422 G/A cg01620082 chr3:125678407 NA -0.69 -6.59 -0.34 1.68e-10 Intelligence (multi-trait analysis); LUSC cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg15485101 chr11:133734466 NA 0.36 6.26 0.32 1.16e-9 Childhood ear infection; LUSC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg19318889 chr4:1322082 MAEA -0.47 -7.73 -0.39 1.27e-13 Obesity-related traits; LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs2073300 0.609 rs6137931 chr20:23376875 G/C cg12062639 chr20:23401060 NAPB 0.94 8.24 0.41 3.94e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7592578 1.000 rs7592578 chr2:191439591 T/G cg11845111 chr2:191398756 TMEM194B 0.86 11.42 0.53 1.01e-25 Diastolic blood pressure; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg13397359 chr6:42928475 GNMT 0.58 9.85 0.47 2.9e-20 Plasma homocysteine levels (post-methionine load test); LUSC cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg26384229 chr12:38710491 ALG10B 0.84 13.62 0.6 6.77e-34 Drug-induced liver injury (flucloxacillin); LUSC cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg09526685 chr4:187126073 CYP4V2 -0.67 -6.71 -0.34 8.49e-11 Blood protein levels; LUSC cis rs25645 0.502 rs8065126 chr17:38099035 C/T cg26162295 chr17:38119207 GSDMA 0.25 5.78 0.3 1.76e-8 Myeloid white cell count; LUSC cis rs12908161 1.000 rs12908549 chr15:85322351 C/G cg17173187 chr15:85201210 NMB 0.47 8.9 0.44 3.57e-17 Schizophrenia; LUSC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg04267008 chr7:1944627 MAD1L1 -0.49 -7.2 -0.37 3.92e-12 Schizophrenia; LUSC cis rs11098499 0.526 rs10026625 chr4:120280136 T/C cg13609457 chr4:120235615 NA 0.37 5.66 0.3 3.22e-8 Corneal astigmatism; LUSC cis rs4474465 0.688 rs7937225 chr11:78278126 T/A cg27205649 chr11:78285834 NARS2 0.59 7.28 0.37 2.38e-12 Alzheimer's disease (survival time); LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.58 -9.37 -0.46 1.14e-18 Lymphocyte counts; LUSC cis rs1506636 0.886 rs6466878 chr7:123272278 T/C cg03229431 chr7:123269106 ASB15 -0.7 -11.62 -0.54 2e-26 Plateletcrit;Platelet count; LUSC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg03929089 chr4:120376271 NA -0.95 -16.52 -0.67 3.18e-45 Height; LUSC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg21854759 chr1:92012499 NA -0.53 -8.87 -0.44 4.35e-17 Breast cancer; LUSC cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg08847533 chr14:75593920 NEK9 -0.54 -8.04 -0.4 1.56e-14 Neuroticism; LUSC cis rs934734 0.789 rs2661798 chr2:65635688 A/T cg08085232 chr2:65598271 SPRED2 0.36 5.66 0.3 3.34e-8 Rheumatoid arthritis; LUSC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.1 14.01 0.61 2.21e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11792861 0.546 rs7873569 chr9:111796753 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 7.56 0.38 3.96e-13 Menarche (age at onset); LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg05564831 chr3:52568323 NT5DC2 0.36 6.66 0.34 1.12e-10 Electroencephalogram traits; LUSC cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg12011299 chr4:100065546 ADH4 0.71 10.8 0.51 1.58e-23 Smoking initiation; LUSC cis rs11122272 0.766 rs2790870 chr1:231543823 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.69 -10.9 -0.51 6.89e-24 Hemoglobin concentration; LUSC cis rs72781680 1.000 rs75046532 chr2:24167267 A/G cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg21782813 chr7:2030301 MAD1L1 0.35 5.75 0.3 1.98e-8 Bipolar disorder and schizophrenia; LUSC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg03709012 chr19:19516395 GATAD2A 0.77 11.94 0.55 1.37e-27 Tonsillectomy; LUSC cis rs11098499 0.863 rs17050695 chr4:120489527 G/T cg09307838 chr4:120376055 NA 0.73 11.99 0.55 8.57e-28 Corneal astigmatism; LUSC cis rs7605827 0.930 rs6748451 chr2:15521088 A/G cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.82e-17 Educational attainment (years of education); LUSC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg04450456 chr4:17643702 FAM184B 0.36 6.0 0.31 5.09e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21381360 chr12:92538746 BTG1 0.69 6.06 0.31 3.7e-9 Cognitive performance; LUSC cis rs8113142 0.614 rs16961775 chr19:29196997 C/A cg04546413 chr19:29218101 NA 0.44 5.93 0.31 7.76e-9 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs243505 0.559 rs2072407 chr7:148508833 A/G cg09806900 chr7:148480153 CUL1 0.64 9.74 0.47 6.86e-20 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7647973 0.961 rs4955443 chr3:49286618 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.79 0.35 5.03e-11 Menarche (age at onset); LUSC trans rs208520 1.000 rs12190316 chr6:66973365 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 12.12 0.55 2.85e-28 Exhaled nitric oxide output; LUSC cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg14993813 chr1:46806288 NSUN4 0.5 7.06 0.36 9.66e-12 Menopause (age at onset); LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg14004847 chr7:1930337 MAD1L1 -0.56 -8.38 -0.42 1.54e-15 Bipolar disorder and schizophrenia; LUSC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg27494647 chr7:150038898 RARRES2 0.54 7.8 0.39 8.01e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg03517284 chr6:25882590 NA -0.52 -9.66 -0.47 1.25e-19 Blood metabolite levels; LUSC cis rs3768617 0.811 rs11590958 chr1:183023636 T/C ch.1.3577855R chr1:183094577 LAMC1 0.6 8.64 0.43 2.41e-16 Fuchs's corneal dystrophy; LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg01802117 chr1:53393560 SCP2 0.39 6.46 0.33 3.72e-10 Monocyte count; LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs11264799 0.603 rs12755544 chr1:157553017 C/T cg18268488 chr1:157545234 FCRL4 0.35 6.42 0.33 4.66e-10 IgA nephropathy; LUSC cis rs12505328 0.966 rs10023094 chr4:174356664 C/T cg12145043 chr4:174357286 NA -0.35 -6.25 -0.32 1.22e-9 Chin dimples; LUSC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg22166914 chr1:53195759 ZYG11B 0.57 9.28 0.45 2.22e-18 Monocyte count; LUSC cis rs61897795 0.657 rs174589 chr11:61615803 C/G cg06781209 chr11:61594997 FADS2 0.37 5.78 0.3 1.69e-8 Neutrophil count;Sum basophil neutrophil counts; LUSC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg24920358 chr1:40204285 PPIE 0.6 10.83 0.51 1.29e-23 Blood protein levels; LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg18402987 chr7:1209562 NA 0.71 7.71 0.39 1.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.3 0.53 2.79e-25 Prudent dietary pattern; LUSC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg25456477 chr12:86230367 RASSF9 0.35 6.25 0.32 1.24e-9 Major depressive disorder; LUSC cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg12908607 chr1:44402522 ARTN -0.48 -7.21 -0.37 3.85e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg22823121 chr1:150693482 HORMAD1 -0.53 -8.14 -0.41 7.93e-15 Tonsillectomy; LUSC cis rs8060686 0.516 rs13339471 chr16:68253008 A/G cg05110241 chr16:68378359 PRMT7 -0.51 -6.42 -0.33 4.73e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs6981523 0.553 rs2409730 chr8:11060638 C/A cg06636001 chr8:8085503 FLJ10661 -0.56 -7.77 -0.39 1.01e-13 Neuroticism; LUSC cis rs7833787 1.000 rs7002237 chr8:18704514 A/G cg17701159 chr8:18705777 PSD3 0.37 6.21 0.32 1.54e-9 Obesity-related traits; LUSC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg20887711 chr4:1340912 KIAA1530 0.53 8.32 0.41 2.22e-15 Longevity; LUSC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg13939156 chr17:80058883 NA -0.33 -6.45 -0.33 3.84e-10 Life satisfaction; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.5 7.58 0.38 3.5e-13 Lymphocyte counts; LUSC cis rs7582720 1.000 rs72926771 chr2:203801226 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.45 -0.42 8.97e-16 Menopause (age at onset); LUSC cis rs2559856 1.000 rs2559855 chr12:102090080 A/G cg12924262 chr12:102091054 CHPT1 -0.44 -5.65 -0.3 3.52e-8 Blood protein levels; LUSC cis rs11098499 0.909 rs10026736 chr4:120384322 G/C cg09307838 chr4:120376055 NA 0.77 10.78 0.51 1.93e-23 Corneal astigmatism; LUSC cis rs9527 0.615 rs7917295 chr10:104701187 A/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.6 -0.34 1.6e-10 Arsenic metabolism; LUSC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg17366294 chr4:99064904 C4orf37 0.56 9.82 0.47 3.53e-20 Colonoscopy-negative controls vs population controls; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02467765 chr4:78978708 FRAS1 0.42 6.39 0.33 5.7e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg18099408 chr3:52552593 STAB1 -0.35 -6.08 -0.32 3.37e-9 Electroencephalogram traits; LUSC cis rs11264799 0.520 rs861998 chr1:157543878 G/A cg18268488 chr1:157545234 FCRL4 0.39 7.45 0.38 7.95e-13 IgA nephropathy; LUSC cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg24642439 chr20:33292090 TP53INP2 -0.48 -7.39 -0.37 1.2e-12 Glomerular filtration rate (creatinine); LUSC cis rs3741798 1.000 rs61922045 chr12:12494394 A/C cg08615371 chr12:12503544 MANSC1 1.08 11.06 0.52 1.87e-24 Cerebrospinal fluid biomarker levels; LUSC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.41 -5.88 -0.31 9.77e-9 Alzheimer's disease (late onset); LUSC cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg11279151 chr3:101281821 RG9MTD1 0.46 7.3 0.37 2.09e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.03 0.64 2.37e-39 Bladder cancer; LUSC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg19318889 chr4:1322082 MAEA 0.5 7.61 0.38 2.91e-13 Obesity-related traits; LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg05025164 chr4:1340916 KIAA1530 -0.51 -7.84 -0.39 6.3e-14 Obesity-related traits; LUSC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg06634786 chr22:41940651 POLR3H 0.51 6.11 0.32 2.82e-9 Vitiligo; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13326172 chr17:34122745 MMP28 0.73 6.45 0.33 3.84e-10 Cognitive performance; LUSC cis rs11718455 0.629 rs4082418 chr3:43908243 C/T cg08738300 chr3:44038990 NA -0.61 -9.33 -0.45 1.46e-18 Coronary artery disease; LUSC cis rs3820068 0.608 rs12091326 chr1:16048005 A/G cg24675056 chr1:15929824 NA 0.41 6.72 0.35 7.82e-11 Systolic blood pressure; LUSC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg16339924 chr4:17578868 LAP3 0.64 10.13 0.48 3.35e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg24739457 chr1:205821442 NA 0.33 5.66 0.3 3.19e-8 Menarche (age at onset); LUSC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg24881330 chr22:46731750 TRMU 0.88 8.82 0.43 6.33e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs5769765 0.865 rs4824108 chr22:50271428 A/G cg08270630 chr22:50330655 NA 0.4 5.98 0.31 5.84e-9 Schizophrenia; LUSC trans rs1547374 0.737 rs178741 chr21:43779408 G/A cg09521743 chr10:75415752 SYNPO2L 0.5 8.96 0.44 2.42e-17 Pancreatic cancer; LUSC cis rs1371867 0.846 rs1788206 chr8:101306966 A/G cg06002616 chr8:101225028 SPAG1 -0.46 -7.57 -0.38 3.77e-13 Atrioventricular conduction; LUSC cis rs2769264 0.593 rs4971040 chr1:151366494 A/C cg18801370 chr1:151430492 POGZ 0.66 7.76 0.39 1.02e-13 Blood trace element (Cu levels); LUSC cis rs9486715 0.867 rs9373833 chr6:96904998 A/G cg06623918 chr6:96969491 KIAA0776 -0.92 -17.47 -0.69 5.16e-49 Headache; LUSC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg06238570 chr21:40685208 BRWD1 -0.62 -10.34 -0.49 6.4e-22 Cognitive function; LUSC cis rs9463078 0.764 rs9367208 chr6:44830180 G/A cg25276700 chr6:44698697 NA -0.28 -5.72 -0.3 2.34e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4280164 1.000 rs4280164 chr14:24771285 G/A cg16194253 chr14:24768981 DHRS1;C14orf21 -0.57 -6.73 -0.35 7.49e-11 Parent of origin effect on language impairment (paternal); LUSC trans rs3733585 0.673 rs7672947 chr4:9961368 G/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs11190604 0.943 rs3750632 chr10:102279295 G/C cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.87 -0.31 1.03e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs11247915 0.583 rs66569416 chr1:26659737 C/G cg15628303 chr1:26608928 UBXN11 0.47 7.67 0.39 1.85e-13 Obesity-related traits; LUSC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.44 -0.33 4.08e-10 Alzheimer's disease (late onset); LUSC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg26659404 chr1:25747437 RHCE -0.28 -5.75 -0.3 2.01e-8 Erythrocyte sedimentation rate; LUSC cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg23158103 chr7:148848205 ZNF398 -0.49 -8.02 -0.4 1.76e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs611744 0.647 rs11774904 chr8:109273435 G/A cg18478394 chr8:109455254 TTC35 0.42 6.54 0.34 2.35e-10 Dupuytren's disease; LUSC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg08888203 chr3:10149979 C3orf24 -0.66 -9.74 -0.47 6.63e-20 Alzheimer's disease; LUSC cis rs35146811 0.555 rs1981550 chr7:99541952 G/A cg22906224 chr7:99728672 NA 0.42 5.68 0.3 2.88e-8 Coronary artery disease; LUSC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg09359103 chr1:154839909 KCNN3 -0.43 -8.17 -0.41 6.59e-15 Schizophrenia; LUSC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg00031303 chr3:195681400 NA 0.67 9.55 0.46 2.79e-19 Pancreatic cancer; LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs2070488 0.775 rs2300669 chr3:38541318 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -12.53 -0.57 8.55e-30 Electrocardiographic conduction measures; LUSC cis rs6690583 0.623 rs1371141 chr1:85455372 C/A cg11262906 chr1:85462892 MCOLN2 0.67 6.53 0.34 2.51e-10 Serum sulfate level; LUSC trans rs35110281 0.748 rs9981460 chr21:45030965 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.66 11.54 0.53 3.8e-26 Mean corpuscular volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg23088430 chr8:144679052 EEF1D;TIGD5 0.36 6.13 0.32 2.49e-9 Triglycerides; LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.71 -0.43 1.38e-16 Bipolar disorder; LUSC cis rs11098499 0.691 rs9995716 chr4:120264996 T/C cg09307838 chr4:120376055 NA 0.64 9.55 0.46 2.93e-19 Corneal astigmatism; LUSC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg21535942 chr1:75199100 CRYZ;TYW3 0.47 7.42 0.38 1e-12 Resistin levels; LUSC trans rs877282 1.000 rs7100358 chr10:773681 G/A cg22713356 chr15:30763199 NA 1.07 15.31 0.64 1.78e-40 Uric acid levels; LUSC cis rs9311676 0.656 rs56028017 chr3:58372508 C/T cg13750441 chr3:58318267 PXK 0.35 6.7 0.34 9.04e-11 Systemic lupus erythematosus; LUSC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg22834771 chr12:69754056 YEATS4 -0.5 -7.45 -0.38 8.09e-13 Blood protein levels; LUSC cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg24596788 chr1:163392923 NA -0.45 -7.66 -0.39 2e-13 Motion sickness; LUSC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg08270630 chr22:50330655 NA -0.42 -6.17 -0.32 1.94e-9 Schizophrenia; LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg12564285 chr5:131593104 PDLIM4 -0.48 -8.3 -0.41 2.69e-15 Breast cancer; LUSC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg10018233 chr7:150070692 REPIN1 0.36 6.35 0.33 7.02e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs7584330 0.652 rs7607231 chr2:238372896 T/C cg16989719 chr2:238392110 NA -0.39 -6.7 -0.34 9.08e-11 Prostate cancer; LUSC cis rs2996428 0.667 rs7545274 chr1:3744261 G/T cg13057898 chr1:3703894 LRRC47 0.49 8.44 0.42 9.58e-16 Red cell distribution width; LUSC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg25838465 chr1:92012736 NA -0.73 -14.78 -0.63 2.21e-38 Breast cancer; LUSC cis rs6582630 0.638 rs7963994 chr12:38555535 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.74 -0.35 6.77e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.95 0.7 6.41e-51 Chronic sinus infection; LUSC cis rs2273669 0.667 rs76094073 chr6:109288036 C/G cg05315195 chr6:109294784 ARMC2 -0.59 -6.44 -0.33 4.18e-10 Prostate cancer; LUSC cis rs10743315 0.557 rs17271690 chr12:19450236 A/G cg02471346 chr12:19282374 PLEKHA5 0.82 6.15 0.32 2.23e-9 Gut microbiota (bacterial taxa); LUSC trans rs11098499 0.754 rs7672594 chr4:120248543 A/C cg25214090 chr10:38739885 LOC399744 0.43 6.56 0.34 2.08e-10 Corneal astigmatism; LUSC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.19e-30 Aortic root size; LUSC cis rs7904368 0.707 rs12253979 chr10:16853415 T/C cg14835575 chr10:16859367 RSU1 0.72 8.84 0.44 5.52e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs1559088 0.847 rs10416218 chr19:33599127 T/C cg17764715 chr19:33622953 WDR88 0.6 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17162190 0.698 rs4659444 chr1:26825116 C/T cg17456097 chr1:26900765 RPS6KA1 0.39 5.75 0.3 1.98e-8 Mean corpuscular volume; LUSC cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.43e-28 Intelligence (multi-trait analysis); LUSC cis rs826838 1.000 rs826886 chr12:39095797 A/G cg26384229 chr12:38710491 ALG10B 0.82 15.09 0.64 1.37e-39 Heart rate; LUSC cis rs9648716 0.515 rs2079827 chr7:140682675 C/T cg23214464 chr7:140373596 ADCK2 0.7 5.92 0.31 7.78e-9 Type 2 diabetes; LUSC cis rs2072499 0.966 rs2244144 chr1:156184598 G/A cg24450063 chr1:156163899 SLC25A44 1.15 23.5 0.79 8.98e-73 Testicular germ cell tumor; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg11645453 chr3:52864694 ITIH4 0.28 6.43 0.33 4.34e-10 Electroencephalogram traits; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.52 -8.0 -0.4 2.09e-14 Prudent dietary pattern; LUSC cis rs1790761 0.967 rs1638588 chr11:67199706 C/A cg24690094 chr11:67383802 NA -0.32 -5.84 -0.3 1.21e-8 Mean corpuscular volume; LUSC cis rs17253792 0.822 rs75663029 chr14:56092385 T/C cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11890956 chr21:40555474 PSMG1 1.04 21.28 0.76 3.93e-64 Cognitive function; LUSC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg08917208 chr2:24149416 ATAD2B 0.53 5.88 0.31 1e-8 Lymphocyte counts; LUSC cis rs897984 0.770 rs12930657 chr16:30931968 C/T cg02466173 chr16:30829666 NA 0.56 11.19 0.52 6.77e-25 Dementia with Lewy bodies; LUSC cis rs9300255 0.510 rs1790109 chr12:123637752 C/G cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.12 -0.32 2.63e-9 Neutrophil percentage of white cells; LUSC cis rs35306767 0.951 rs55742421 chr10:961037 A/C cg25019033 chr10:957182 NA -0.55 -6.33 -0.33 8e-10 Eosinophil percentage of granulocytes; LUSC cis rs4663866 0.901 rs3739067 chr2:239184203 G/A cg16914508 chr2:239161102 PER2 0.65 6.86 0.35 3.26e-11 Irritable bowel syndrome; LUSC cis rs7216064 0.953 rs12450907 chr17:65870644 T/G cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg00791764 chr4:53727839 RASL11B 0.58 7.98 0.4 2.42e-14 Optic nerve measurement (cup area); LUSC cis rs9399135 0.967 rs7763836 chr6:135362378 T/C cg24558204 chr6:135376177 HBS1L 0.58 8.94 0.44 2.75e-17 Red blood cell count; LUSC cis rs72634258 0.699 rs2493214 chr1:7994420 A/G cg00042356 chr1:8021962 PARK7 0.58 7.59 0.38 3.29e-13 Inflammatory bowel disease; LUSC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg18225595 chr11:63971243 STIP1 0.54 9.16 0.45 5.45e-18 Platelet count; LUSC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC trans rs1015291 0.806 rs2638431 chr12:19986746 A/G cg01501474 chr7:55323552 NA 0.47 6.32 0.33 8.39e-10 Diastolic blood pressure; LUSC trans rs9929218 0.953 rs17772411 chr16:68810923 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -11.47 -0.53 6.87e-26 Colorectal cancer; LUSC cis rs2933343 0.700 rs2630257 chr3:128644015 T/C cg11901034 chr3:128598214 ACAD9 -0.41 -6.47 -0.33 3.54e-10 IgG glycosylation; LUSC cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg17420585 chr12:42539391 GXYLT1 -0.37 -7.15 -0.36 5.52e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9314323 0.729 rs7823021 chr8:26224958 G/T cg11498726 chr8:26250323 BNIP3L -0.43 -6.18 -0.32 1.9e-9 Red cell distribution width; LUSC cis rs1729951 0.575 rs1682357 chr3:136692009 G/A cg12473912 chr3:136751656 NA 0.39 6.81 0.35 4.51e-11 Neuroticism; LUSC trans rs6030 1.000 rs1557572 chr1:169508576 A/C cg16792071 chr10:134842795 NA 0.28 6.06 0.31 3.58e-9 Uric acid levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09861171 chr8:95731968 DPY19L4 0.41 6.26 0.32 1.17e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7223966 1.000 rs9747164 chr17:61864787 T/C cg00945038 chr17:61921165 SMARCD2 0.39 5.67 0.3 3.08e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs8114671 0.967 rs1577924 chr20:33784288 C/G cg24642439 chr20:33292090 TP53INP2 -0.39 -5.67 -0.3 3.01e-8 Height; LUSC cis rs7582180 0.700 rs4851303 chr2:100962064 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.69 -0.43 1.66e-16 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.11e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg26513180 chr16:89883248 FANCA 0.9 17.4 0.69 1.04e-48 Vitiligo; LUSC cis rs782590 0.807 rs782642 chr2:55928444 G/T cg18811423 chr2:55921094 PNPT1 0.89 15.55 0.65 2.09e-41 Metabolic syndrome; LUSC cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg12751644 chr20:60527061 NA -0.33 -5.99 -0.31 5.41e-9 Body mass index; LUSC cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg03684893 chr10:554711 DIP2C -0.39 -7.22 -0.37 3.59e-12 Psychosis in Alzheimer's disease; LUSC cis rs1577917 0.958 rs10455448 chr6:86533611 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs9473147 0.516 rs7754971 chr6:47590476 C/T cg20196966 chr6:47445060 CD2AP 0.43 6.08 0.32 3.24e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -15.52 -0.65 2.9e-41 Prostate cancer; LUSC cis rs6494488 0.500 rs72744751 chr15:65064657 C/T cg08069370 chr15:64387884 SNX1 -0.65 -5.91 -0.31 8.23e-9 Coronary artery disease; LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg00166722 chr3:10149974 C3orf24 0.63 8.91 0.44 3.26e-17 Alzheimer's disease; LUSC cis rs6429082 0.807 rs4659857 chr1:235581411 C/T cg26050004 chr1:235667680 B3GALNT2 -0.55 -7.81 -0.39 7.26e-14 Adiposity; LUSC cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg08085267 chr17:45401833 C17orf57 0.54 8.82 0.43 6.58e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg03526776 chr6:41159608 TREML2 0.32 6.12 0.32 2.62e-9 Alzheimer's disease (late onset); LUSC cis rs262150 0.545 rs73167302 chr7:158789762 G/A cg19418458 chr7:158789849 NA 0.55 7.16 0.36 5.1e-12 Facial morphology (factor 20); LUSC cis rs10089 0.903 rs6862701 chr5:127391249 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 12.09 0.55 3.72e-28 Ileal carcinoids; LUSC cis rs834811 0.829 rs10252049 chr7:135903178 G/A cg01726295 chr7:135938950 NA -0.39 -6.82 -0.35 4.37e-11 Post-traumatic stress disorder; LUSC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.12 0.32 2.64e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1595825 0.891 rs59938443 chr2:198497105 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.67 -0.34 1.04e-10 Ulcerative colitis; LUSC cis rs7945705 0.875 rs10769957 chr11:8809016 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -9.95 -0.48 1.37e-20 Hemoglobin concentration; LUSC cis rs2932538 0.883 rs7549547 chr1:113086717 A/T cg22162597 chr1:113214053 CAPZA1 0.69 10.04 0.48 6.82e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg12641515 chr19:46296257 DMWD 0.48 7.22 0.37 3.63e-12 Coronary artery disease; LUSC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg16049864 chr8:95962084 TP53INP1 0.62 10.88 0.51 8.36e-24 Type 2 diabetes; LUSC cis rs7106204 0.764 rs79427715 chr11:24247046 G/A ch.11.24196551F chr11:24239977 NA 0.92 7.85 0.39 5.82e-14 Response to Homoharringtonine (cytotoxicity); LUSC cis rs73206853 0.619 rs112148402 chr12:111171493 T/C cg12870014 chr12:110450643 ANKRD13A 0.69 7.34 0.37 1.62e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg23505145 chr19:12996616 KLF1 0.64 10.7 0.51 3.62e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg00999904 chr2:3704751 ALLC -0.43 -6.67 -0.34 1.06e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg25817165 chr18:72167213 CNDP2 -0.75 -9.0 -0.44 1.8e-17 Refractive error; LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg17178900 chr1:205818956 PM20D1 0.84 14.54 0.62 1.97e-37 Menarche (age at onset); LUSC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg01973587 chr1:228161476 NA -0.41 -7.39 -0.37 1.17e-12 Diastolic blood pressure; LUSC cis rs7011049 0.673 rs17256515 chr8:53827232 C/T cg26025543 chr8:53854495 NA 0.46 6.22 0.32 1.48e-9 Systolic blood pressure; LUSC cis rs9287719 0.967 rs6755548 chr2:10746126 A/G cg00105475 chr2:10696890 NA 0.38 6.27 0.32 1.11e-9 Prostate cancer; LUSC cis rs6845621 0.901 rs6834863 chr4:18919159 C/A cg12196642 chr4:18937545 NA -0.34 -6.37 -0.33 6.12e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.3 0.53 2.77e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs6952808 0.964 rs6945719 chr7:1932688 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.3 0.33 9.27e-10 Bipolar disorder and schizophrenia; LUSC cis rs193541 0.626 rs6878780 chr5:122093740 T/C cg19077854 chr5:122220652 SNX24 0.28 6.26 0.32 1.22e-9 Glucose homeostasis traits; LUSC cis rs6009527 1.000 rs2318941 chr22:49573400 G/A cg12746016 chr22:49560550 NA 0.35 6.0 0.31 5.19e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg17968037 chr7:100024898 ZCWPW1 -0.43 -6.2 -0.32 1.63e-9 Platelet count; LUSC cis rs2361710 0.611 rs3816257 chr17:78074446 G/T cg24585782 chr17:78113791 EIF4A3 0.46 7.26 0.37 2.68e-12 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg11764359 chr7:65958608 NA -0.58 -8.99 -0.44 1.87e-17 Aortic root size; LUSC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.52 6.52 0.34 2.6200000000000003e-10 Renal function-related traits (BUN); LUSC trans rs561341 0.882 rs111484028 chr17:30287701 G/A cg27661571 chr11:113659931 NA -0.59 -7.18 -0.37 4.61e-12 Hip circumference adjusted for BMI; LUSC trans rs17685 0.753 rs11764129 chr7:75761890 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1372520 0.577 rs1811443 chr4:90747883 G/C cg15133208 chr4:90757351 SNCA -0.53 -8.16 -0.41 6.98e-15 Neuroticism; LUSC cis rs7527798 0.592 rs12563520 chr1:207844062 C/T cg09232269 chr1:207846808 CR1L -0.28 -6.0 -0.31 5.05e-9 Erythrocyte sedimentation rate; LUSC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg18758796 chr5:131593413 PDLIM4 0.36 6.19 0.32 1.81e-9 Blood metabolite levels; LUSC cis rs8017423 0.934 rs11159952 chr14:90684874 T/C cg04374321 chr14:90722782 PSMC1 0.71 11.26 0.52 3.82e-25 Mortality in heart failure; LUSC cis rs3892630 0.824 rs34748593 chr19:33240447 T/C cg22980127 chr19:33182716 NUDT19 0.91 12.49 0.56 1.25e-29 Red blood cell traits; LUSC cis rs11676348 0.846 rs3890158 chr2:218990292 G/A cg00012203 chr2:219082015 ARPC2 -0.57 -9.03 -0.44 1.37e-17 Ulcerative colitis; LUSC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg13393036 chr8:95962371 TP53INP1 0.3 6.16 0.32 2.12e-9 Alzheimer's disease (late onset); LUSC cis rs4776059 1.000 rs4776066 chr15:52930499 T/C cg22715398 chr15:52968154 KIAA1370 -0.65 -9.41 -0.46 8.6e-19 Schizophrenia; LUSC cis rs9467773 1.000 rs9357010 chr6:26527945 C/G cg09904177 chr6:26538194 HMGN4 0.77 14.98 0.63 3.78e-39 Intelligence (multi-trait analysis); LUSC cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg12573674 chr2:1569213 NA -0.63 -8.69 -0.43 1.66e-16 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs1559088 0.895 rs7259582 chr19:33593979 A/G cg03563238 chr19:33554763 RHPN2 -0.41 -6.56 -0.34 2.09e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs877282 0.700 rs816311 chr10:796490 C/A cg22713356 chr15:30763199 NA 0.9 13.19 0.59 2.94e-32 Uric acid levels; LUSC cis rs2413583 0.536 rs17304621 chr22:39690791 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.65 6.24 0.32 1.36e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs12986413 0.874 rs4806832 chr19:2184652 C/T cg09261902 chr19:2140048 AP3D1 0.31 5.68 0.3 2.92e-8 Height; LUSC cis rs7589342 0.536 rs55830542 chr2:106387206 C/T cg09152813 chr2:106391379 NCK2 -0.38 -6.24 -0.32 1.31e-9 Addiction; LUSC cis rs367943 1.000 rs348931 chr5:112812864 G/C cg12552261 chr5:112820674 MCC -0.43 -6.95 -0.36 1.98e-11 Type 2 diabetes; LUSC cis rs7336332 0.598 rs77055070 chr13:28010516 C/G cg22138327 chr13:27999177 GTF3A 0.8 10.02 0.48 7.6e-21 Weight; LUSC cis rs6834538 0.597 rs4833414 chr4:113469913 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.36 5.82 0.3 1.37e-8 Free thyroxine concentration; LUSC cis rs9303401 0.659 rs17222523 chr17:56620501 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.88 13.71 0.6 2.89e-34 Cognitive test performance; LUSC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.88 15.29 0.64 2.21e-40 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs62400317 0.859 rs10456122 chr6:45163057 C/G cg18551225 chr6:44695536 NA -0.44 -7.2 -0.37 4.1e-12 Total body bone mineral density; LUSC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg02034447 chr16:89574710 SPG7 0.4 5.87 0.31 1.05e-8 Multiple myeloma (IgH translocation); LUSC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg06212747 chr3:49208901 KLHDC8B 0.53 7.03 0.36 1.17e-11 Parkinson's disease; LUSC cis rs6723226 0.503 rs4952262 chr2:32597234 G/A cg02381751 chr2:32503542 YIPF4 -0.51 -7.56 -0.38 3.91e-13 Intelligence (multi-trait analysis); LUSC cis rs11112613 0.775 rs12305225 chr12:105963266 G/C cg03607813 chr12:105948248 NA 0.74 10.47 0.5 2.35e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs7903847 0.642 rs10882908 chr10:99134970 T/C cg20016023 chr10:99160130 RRP12 -0.34 -8.41 -0.42 1.2e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs4919687 0.550 rs12780827 chr10:104467954 T/C cg04362960 chr10:104952993 NT5C2 0.46 6.55 0.34 2.12e-10 Colorectal cancer; LUSC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg24642844 chr7:1081250 C7orf50 -0.46 -7.39 -0.37 1.21e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs11153730 0.503 rs283042 chr6:118631282 G/A cg21191810 chr6:118973309 C6orf204 0.34 5.77 0.3 1.78e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); LUSC cis rs2011503 0.882 rs10423874 chr19:19359500 C/G cg11244672 chr19:19639970 YJEFN3 -0.54 -6.56 -0.34 1.99e-10 Bipolar disorder; LUSC cis rs2486288 0.656 rs2413771 chr15:45553140 A/G cg09092052 chr15:45571596 NA 0.44 6.29 0.33 1e-9 Glomerular filtration rate; LUSC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg13531842 chr10:38383804 ZNF37A -0.45 -6.95 -0.36 1.91e-11 Extrinsic epigenetic age acceleration; LUSC cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.81 0.43 6.77e-17 Axial length; LUSC trans rs3733585 0.624 rs7376154 chr4:9952587 C/A cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.13e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg24675658 chr1:53192096 ZYG11B -0.56 -8.86 -0.44 4.82e-17 Monocyte count; LUSC cis rs2573652 0.723 rs2727201 chr15:100515311 A/G cg09918751 chr15:100517450 ADAMTS17 -0.51 -9.47 -0.46 5.36e-19 Height; LUSC cis rs2370759 1.000 rs75984055 chr10:32591276 T/C cg01819863 chr10:32635814 EPC1 1.07 13.24 0.59 1.9e-32 Sexual dysfunction (female); LUSC cis rs8062405 1.000 rs62036616 chr16:28826307 A/G cg09754948 chr16:28834200 ATXN2L 0.45 6.45 0.33 3.83e-10 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6545883 0.894 rs2593633 chr2:61571513 T/C cg15711740 chr2:61764176 XPO1 0.42 6.5 0.34 2.87e-10 Tuberculosis; LUSC cis rs7224314 1.000 rs6504503 chr17:65386690 A/T cg01507342 chr17:65387096 PITPNC1 -0.42 -7.54 -0.38 4.58e-13 Diisocyanate-induced asthma; LUSC cis rs6494488 0.500 rs72742913 chr15:64846710 G/A cg08069370 chr15:64387884 SNX1 -0.64 -5.73 -0.3 2.26e-8 Coronary artery disease; LUSC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg06634786 chr22:41940651 POLR3H 0.51 6.1 0.32 2.91e-9 Vitiligo; LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg07660663 chr8:117886887 RAD21 0.47 6.12 0.32 2.67e-9 Thyroid stimulating hormone; LUSC trans rs60843830 1.000 rs36216559 chr2:262335 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.35 0.49 5.71e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 10.1 0.48 4.1e-21 Bipolar disorder; LUSC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -6.9 -0.35 2.65e-11 Developmental language disorder (linguistic errors); LUSC cis rs2274273 0.870 rs8018110 chr14:55641714 C/T cg04306507 chr14:55594613 LGALS3 0.58 13.58 0.6 9.41e-34 Protein biomarker; LUSC cis rs6867032 0.527 rs4975777 chr5:1973324 G/T cg26168224 chr5:2018326 NA -0.53 -7.42 -0.38 9.89e-13 Gut microbiome composition (winter); LUSC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg24250549 chr1:154909240 PMVK 0.64 10.35 0.49 5.96e-22 Prostate cancer; LUSC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.19 -0.37 4.4e-12 Developmental language disorder (linguistic errors); LUSC cis rs10791097 0.694 rs1054869 chr11:130742630 G/A cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs9329221 0.905 rs28507213 chr8:10250849 C/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.6 -0.34 1.61e-10 Neuroticism; LUSC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg18876405 chr7:65276391 NA -0.53 -8.4 -0.42 1.28e-15 Aortic root size; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg08280861 chr8:58055591 NA 0.53 5.81 0.3 1.5e-8 Developmental language disorder (linguistic errors); LUSC cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg06022373 chr22:39101656 GTPBP1 -0.65 -10.0 -0.48 8.97e-21 Menopause (age at onset); LUSC cis rs7246657 0.943 rs7253091 chr19:37967214 C/T cg23950597 chr19:37808831 NA -0.62 -7.38 -0.37 1.27e-12 Coronary artery calcification; LUSC cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg00071950 chr4:10020882 SLC2A9 0.48 7.79 0.39 8.76e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg25072359 chr17:41440525 NA 0.68 9.5 0.46 4.34e-19 Menopause (age at onset); LUSC cis rs1185460 0.967 rs1786141 chr11:118938315 C/T cg23280166 chr11:118938394 VPS11 0.47 7.24 0.37 3.07e-12 Coronary artery disease; LUSC trans rs6502050 0.835 rs6502059 chr17:80082886 T/C cg07393940 chr7:158741817 NA -0.37 -6.63 -0.34 1.36e-10 Life satisfaction; LUSC cis rs10170310 1.000 rs10803568 chr2:139290914 T/C cg03782584 chr2:139258740 SPOPL 0.33 5.74 0.3 2.17e-8 Response to antipsychotic treatment; LUSC cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg08999081 chr20:33150536 PIGU 0.52 10.44 0.5 2.89e-22 Glomerular filtration rate (creatinine); LUSC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.61 -0.38 2.81e-13 Height; LUSC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg11764359 chr7:65958608 NA 0.68 10.94 0.51 4.97e-24 Aortic root size; LUSC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.63 13.71 0.6 3.01e-34 Hemoglobin concentration; LUSC cis rs4363385 0.818 rs2070964 chr1:153004213 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.66 -0.3 3.33e-8 Inflammatory skin disease; LUSC cis rs1322512 0.917 rs2258926 chr6:152973974 C/T cg27316956 chr6:152958899 SYNE1 -0.37 -6.3 -0.33 9.2e-10 Tonometry; LUSC cis rs3862030 0.720 rs11593526 chr10:104228017 G/T cg05855489 chr10:104503620 C10orf26 0.46 7.08 0.36 8.39e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg23422044 chr7:1970798 MAD1L1 -0.59 -6.63 -0.34 1.32e-10 Neuroticism; LUSC cis rs7572644 0.713 rs4666025 chr2:28073894 C/T cg27432699 chr2:27873401 GPN1 0.52 6.62 0.34 1.45e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs477692 0.699 rs576175 chr10:131386408 A/T cg26102564 chr10:131424627 MGMT 0.4 6.07 0.32 3.41e-9 Response to temozolomide; LUSC cis rs1790761 0.692 rs611663 chr11:67312221 C/T cg00864171 chr11:67383662 NA 0.34 6.06 0.31 3.7e-9 Mean corpuscular volume; LUSC cis rs3087591 0.922 rs757383 chr17:29596045 C/G cg24425628 chr17:29625626 OMG;NF1 0.56 8.14 0.41 8.05e-15 Hip circumference; LUSC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg11764359 chr7:65958608 NA 0.63 9.45 0.46 6.07e-19 Calcium levels; LUSC cis rs9296092 0.500 rs35150558 chr6:33519612 T/A cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs6500602 0.929 rs6500603 chr16:4497537 G/C cg08645402 chr16:4508243 NA 0.53 8.8 0.43 7.36e-17 Schizophrenia; LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg24675658 chr1:53192096 ZYG11B -0.67 -11.08 -0.52 1.7e-24 Monocyte count; LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18301423 chr5:131593218 PDLIM4 0.47 7.48 0.38 6.75e-13 Acylcarnitine levels; LUSC cis rs9910055 0.659 rs2246287 chr17:42232442 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.5 9.05 0.44 1.25e-17 Total body bone mineral density; LUSC cis rs174601 0.668 rs174559 chr11:61581656 G/A cg19610905 chr11:61596333 FADS2 -0.54 -7.68 -0.39 1.82e-13 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14995716 chr1:32687918 C1orf91;EIF3I -0.43 -6.03 -0.31 4.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs34779708 0.966 rs1478463 chr10:35473035 G/A cg04310649 chr10:35416472 CREM -0.43 -6.7 -0.34 9.05e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4919687 0.550 rs4264100 chr10:104454113 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -5.89 -0.31 9.25e-9 Colorectal cancer; LUSC cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg05535760 chr7:792225 HEATR2 0.79 9.68 0.47 1.06e-19 Cerebrospinal P-tau181p levels; LUSC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg15664640 chr17:80829946 TBCD 0.49 8.68 0.43 1.73e-16 Breast cancer; LUSC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg18876405 chr7:65276391 NA -0.58 -9.51 -0.46 4.03e-19 Aortic root size; LUSC cis rs7923609 0.811 rs3847325 chr10:65331511 G/C cg01631684 chr10:65280961 REEP3 0.4 5.92 0.31 7.83e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs950776 0.593 rs481134 chr15:78877563 C/T cg22563815 chr15:78856949 CHRNA5 0.25 5.98 0.31 5.68e-9 Sudden cardiac arrest; LUSC cis rs9311676 0.632 rs62258094 chr3:58371770 T/G cg13750441 chr3:58318267 PXK 0.35 6.7 0.34 9.04e-11 Systemic lupus erythematosus; LUSC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.05e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7582720 1.000 rs72934764 chr2:203758521 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs28647808 0.881 rs28622217 chr9:136267323 A/G cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs4805272 0.512 rs4805279 chr19:29336966 A/G cg04546413 chr19:29218101 NA 0.56 7.2 0.37 4.1e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs7615952 0.515 rs7637246 chr3:125678706 A/G cg07211511 chr3:129823064 LOC729375 -0.81 -10.59 -0.5 8.36e-23 Blood pressure (smoking interaction); LUSC cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg13334819 chr7:99746414 C7orf59 -0.42 -5.7 -0.3 2.64e-8 Coronary artery disease; LUSC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg10523679 chr1:76189770 ACADM 0.88 14.24 0.61 2.76e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.26 -0.49 1.22e-21 Alzheimer's disease; LUSC cis rs7296418 0.961 rs4275659 chr12:123447928 C/T cg00376283 chr12:123451042 ABCB9 -0.79 -12.12 -0.55 2.85e-28 Platelet count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06792154 chr17:29157990 ATAD5 0.42 6.12 0.32 2.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7106204 0.514 rs7117803 chr11:24253214 A/T ch.11.24196551F chr11:24239977 NA 0.92 10.2 0.49 1.98e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs427941 0.669 rs417013 chr7:101820155 G/A cg06246474 chr7:101738831 CUX1 0.35 5.69 0.3 2.83e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs478304 0.651 rs11537193 chr11:65500003 A/C cg05805236 chr11:65401703 PCNXL3 -0.57 -9.25 -0.45 2.79e-18 Acne (severe); LUSC cis rs6964587 1.000 rs56072181 chr7:91690457 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg13319975 chr6:146136371 FBXO30 0.51 7.73 0.39 1.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg21724239 chr8:58056113 NA -0.56 -6.92 -0.35 2.3e-11 Developmental language disorder (linguistic errors); LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.63 9.73 0.47 7.25e-20 Lymphocyte counts; LUSC cis rs870825 0.929 rs72689273 chr4:185592750 C/T cg04058563 chr4:185651563 MLF1IP 0.84 11.77 0.54 5.29e-27 Blood protein levels; LUSC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.48 -9.22 -0.45 3.42e-18 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg05347473 chr6:146136440 FBXO30 -0.59 -10.32 -0.49 7.39e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg05863683 chr7:1912471 MAD1L1 0.3 5.69 0.3 2.74e-8 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.532 rs12512646 chr4:120585733 G/A cg24375607 chr4:120327624 NA 0.74 11.06 0.52 1.94e-24 Corneal astigmatism; LUSC cis rs7166081 0.688 rs4776361 chr15:67762056 G/A cg24579218 chr15:68104479 NA -0.34 -5.74 -0.3 2.17e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21201659 chr10:121652288 SEC23IP -0.43 -6.14 -0.32 2.33e-9 Electrocardiographic conduction measures; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13854399 chr2:203736430 ICA1L -0.42 -6.3 -0.33 9.16e-10 Electrocardiographic conduction measures; LUSC trans rs13112683 0.638 rs2667364 chr4:140782082 C/T cg23590389 chr7:157102769 NA -0.31 -5.98 -0.31 5.58e-9 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg11494091 chr17:61959527 GH2 -0.57 -11.99 -0.55 8.37e-28 Prudent dietary pattern; LUSC cis rs1577917 1.000 rs12663690 chr6:86640162 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.14 0.41 8.06e-15 Response to antipsychotic treatment; LUSC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg08219700 chr8:58056026 NA 0.5 6.39 0.33 5.55e-10 Developmental language disorder (linguistic errors); LUSC cis rs77633900 0.772 rs157778 chr15:76759444 G/C cg21673338 chr15:77095150 SCAPER -0.72 -6.25 -0.32 1.23e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg22681709 chr2:178499509 PDE11A -0.49 -7.61 -0.38 2.82e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg27446573 chr6:127587934 RNF146 0.81 12.85 0.58 5.63e-31 Breast cancer; LUSC cis rs6496667 0.533 rs2601206 chr15:90962699 C/T cg10434728 chr15:90938212 IQGAP1 0.31 5.81 0.3 1.45e-8 Rheumatoid arthritis; LUSC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg04414720 chr1:150670196 GOLPH3L 0.49 7.74 0.39 1.17e-13 Melanoma; LUSC cis rs17253792 0.731 rs74829671 chr14:56112759 G/C cg01858014 chr14:56050164 KTN1 -0.81 -6.82 -0.35 4.32e-11 Putamen volume; LUSC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg02187348 chr16:89574699 SPG7 0.6 9.86 0.47 2.67e-20 Multiple myeloma (IgH translocation); LUSC cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.35 0.56 4.21e-29 Motion sickness; LUSC cis rs3936840 0.539 rs11850701 chr14:102983857 G/A cg18135206 chr14:102964638 TECPR2 0.51 6.39 0.33 5.6e-10 Plateletcrit; LUSC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg22875332 chr1:76189707 ACADM 0.78 11.33 0.53 2.21e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg20848291 chr7:100343083 ZAN -0.63 -8.96 -0.44 2.28e-17 Other erythrocyte phenotypes; LUSC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs72781680 1.000 rs72796316 chr2:24132272 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC trans rs2228479 0.702 rs11076620 chr16:89831520 A/T cg24644049 chr4:85504048 CDS1 0.88 7.53 0.38 4.81e-13 Skin colour saturation; LUSC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg26677194 chr12:130822605 PIWIL1 0.59 8.77 0.43 9.52e-17 Menopause (age at onset); LUSC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg22875332 chr1:76189707 ACADM 0.86 14.12 0.61 7.7e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11051970 0.918 rs325417 chr12:32574217 A/G cg24626660 chr12:32551988 NA 0.36 6.14 0.32 2.37e-9 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg01341218 chr17:43662625 NA -0.73 -10.68 -0.5 4.35e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs11758351 1.000 rs3734530 chr6:26195408 G/C cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC trans rs6502050 0.764 rs28676462 chr17:80105100 G/C cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC trans rs35110281 0.748 rs2838322 chr21:44998615 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.98 0.51 3.7e-24 Mean corpuscular volume; LUSC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg15704280 chr7:45808275 SEPT13 -0.83 -13.97 -0.61 2.97e-35 Height; LUSC cis rs7267979 0.932 rs6115214 chr20:25557426 C/T cg03522245 chr20:25566470 NINL -0.36 -5.79 -0.3 1.64e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg03388025 chr16:89894329 SPIRE2 0.34 6.94 0.35 2.1e-11 Vitiligo; LUSC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg10523679 chr1:76189770 ACADM 0.85 11.3 0.53 2.74e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs35146811 0.589 rs1727142 chr7:99816179 T/C cg22906224 chr7:99728672 NA -0.46 -6.18 -0.32 1.83e-9 Coronary artery disease; LUSC cis rs6489882 0.867 rs7305035 chr12:113365803 T/C cg20102336 chr12:113376681 OAS3 -0.4 -5.7 -0.3 2.59e-8 Chronic lymphocytic leukemia; LUSC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg02569458 chr12:86230093 RASSF9 0.58 9.84 0.47 3.05e-20 Major depressive disorder; LUSC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs79149102 0.649 rs1531163 chr15:75113083 A/G cg09165964 chr15:75287851 SCAMP5 -0.84 -5.9 -0.31 8.85e-9 Lung cancer; LUSC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg00701064 chr4:6280414 WFS1 -0.54 -13.77 -0.6 1.79e-34 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs11785400 1.000 rs4484678 chr8:143730796 A/G cg24634471 chr8:143751801 JRK 0.6 8.99 0.44 1.83e-17 Schizophrenia; LUSC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg04756594 chr16:24857601 SLC5A11 0.46 6.62 0.34 1.47e-10 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg15556689 chr8:8085844 FLJ10661 0.69 11.68 0.54 1.17e-26 Mood instability; LUSC cis rs4589502 0.800 rs4776855 chr15:67202075 T/C cg09911534 chr15:67153556 NA 0.5 6.43 0.33 4.51e-10 Lung cancer (smoking interaction); LUSC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg08886695 chr4:3369023 RGS12 -0.37 -5.73 -0.3 2.2e-8 Serum sulfate level; LUSC cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.21 0.49 1.83e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7246657 0.551 rs12972146 chr19:37626095 G/T cg23950597 chr19:37808831 NA -0.53 -5.79 -0.3 1.59e-8 Coronary artery calcification; LUSC cis rs7572644 0.603 rs4666013 chr2:28019106 C/T cg27432699 chr2:27873401 GPN1 0.55 7.26 0.37 2.74e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs877282 0.685 rs56234340 chr10:781339 A/G cg17470449 chr10:769945 NA 0.44 6.24 0.32 1.32e-9 Uric acid levels; LUSC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg06221963 chr1:154839813 KCNN3 -0.67 -16.18 -0.66 6.96e-44 Prostate cancer; LUSC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15506890 chr2:3487001 NA -0.56 -9.51 -0.46 3.77e-19 Neurofibrillary tangles; LUSC cis rs4072705 0.904 rs721863 chr9:127536267 A/T cg13476313 chr9:127244764 NR5A1 0.3 5.97 0.31 6.1e-9 Menarche (age at onset); LUSC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg18654377 chr3:49208889 KLHDC8B -0.45 -5.93 -0.31 7.38e-9 Menarche (age at onset); LUSC cis rs8031584 1.000 rs35607976 chr15:31277788 T/C cg08109568 chr15:31115862 NA -0.66 -9.07 -0.44 1.01e-17 Huntington's disease progression; LUSC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs6500395 1.000 rs7206647 chr16:48709220 G/C cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg13010199 chr12:38710504 ALG10B 0.66 9.86 0.47 2.65e-20 Bladder cancer; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg13047869 chr3:10149882 C3orf24 0.6 8.23 0.41 4.26e-15 Alzheimer's disease; LUSC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg06219351 chr7:158114137 PTPRN2 0.5 9.02 0.44 1.51e-17 Calcium levels; LUSC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg07701084 chr6:150067640 NUP43 0.57 8.66 0.43 1.98e-16 Lung cancer; LUSC cis rs1971762 0.563 rs4759285 chr12:54079513 G/T cg23533419 chr12:54090519 NA -0.35 -5.82 -0.3 1.41e-8 Height; LUSC cis rs6840360 0.593 rs7654294 chr4:152690975 T/C cg22705602 chr4:152727874 NA -0.39 -8.61 -0.43 3.03e-16 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg11645453 chr3:52864694 ITIH4 0.35 8.14 0.41 7.76e-15 Bipolar disorder; LUSC cis rs908922 0.651 rs11205035 chr1:152532832 A/G cg20991723 chr1:152506922 NA 0.5 9.18 0.45 4.77e-18 Hair morphology; LUSC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg20790798 chr5:1857306 NA -0.49 -8.5 -0.42 6.19e-16 Cardiovascular disease risk factors; LUSC cis rs2742540 0.524 rs2653562 chr11:8918160 A/T cg12365402 chr11:9010492 NRIP3 -0.4 -6.92 -0.35 2.29e-11 Hematocrit; LUSC cis rs4319547 0.695 rs4758648 chr12:122900460 A/G cg23029597 chr12:123009494 RSRC2 -0.64 -8.41 -0.42 1.21e-15 Body mass index; LUSC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22509189 chr2:225307070 NA -0.49 -6.37 -0.33 6.13e-10 IgE levels in asthmatics (D.p. specific); LUSC cis rs9359856 0.564 rs17292425 chr6:90372128 A/G cg13799429 chr6:90582589 CASP8AP2 -0.89 -8.73 -0.43 1.25e-16 Bipolar disorder; LUSC cis rs225245 0.817 rs225299 chr17:33922742 T/C cg05299278 chr17:33885742 SLFN14 0.31 6.85 0.35 3.64e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs11971779 0.938 rs11981688 chr7:139088895 A/G cg07862535 chr7:139043722 LUC7L2 0.73 8.41 0.42 1.23e-15 Diisocyanate-induced asthma; LUSC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg11812906 chr14:75593930 NEK9 -0.65 -10.19 -0.49 2.08e-21 Height; LUSC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.15 0.49 2.78e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3820928 0.874 rs4675134 chr2:227843489 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.83 -0.39 6.69e-14 Pulmonary function; LUSC trans rs7824557 0.564 rs2736293 chr8:11234613 T/A cg08975724 chr8:8085496 FLJ10661 -0.42 -6.21 -0.32 1.56e-9 Retinal vascular caliber; LUSC trans rs12043259 1.000 rs4370813 chr1:204852893 A/G cg23865240 chr7:27134109 HOXA1 0.56 6.06 0.31 3.6e-9 Addiction; LUSC cis rs17270561 0.609 rs9358883 chr6:25755515 A/G cg17691542 chr6:26056736 HIST1H1C 0.58 8.09 0.4 1.13e-14 Iron status biomarkers; LUSC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg17971929 chr21:40555470 PSMG1 0.79 13.99 0.61 2.56e-35 Cognitive function; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg06877462 chr1:205807181 PM20D1 0.47 8.48 0.42 7.53e-16 Menarche (age at onset); LUSC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg01982873 chr5:490308 SLC9A3 -0.35 -6.29 -0.33 1.02e-9 Cystic fibrosis severity; LUSC cis rs12541635 0.677 rs10086055 chr8:107024129 C/T cg10147462 chr8:107024639 NA 0.67 14.1 0.61 9.64e-36 Age of smoking initiation; LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.57 8.68 0.43 1.72e-16 Lymphocyte counts; LUSC cis rs7582720 1.000 rs6738618 chr2:203749439 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs561341 0.941 rs4795664 chr17:30233467 C/T cg20587970 chr11:113659929 NA -1.11 -13.57 -0.6 1.02e-33 Hip circumference adjusted for BMI; LUSC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg20406979 chr6:167373233 NA -0.26 -5.95 -0.31 6.67e-9 Crohn's disease; LUSC cis rs11155671 0.530 rs6939761 chr6:150210994 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.85 -0.3 1.18e-8 Testicular germ cell tumor; LUSC cis rs2652834 0.851 rs2729823 chr15:63420660 A/G cg05507819 chr15:63340323 TPM1 0.47 6.06 0.31 3.77e-9 HDL cholesterol; LUSC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg20203395 chr5:56204925 C5orf35 -0.76 -10.1 -0.48 4.17e-21 Initial pursuit acceleration; LUSC cis rs4665809 0.590 rs11126339 chr2:26253223 T/C cg08470875 chr2:26401718 FAM59B -0.53 -6.81 -0.35 4.5e-11 Gut microbiome composition (summer); LUSC cis rs7267979 0.966 rs6083855 chr20:25405118 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.35e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9815354 0.680 rs73073285 chr3:42027566 T/G cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg06145435 chr7:1022769 CYP2W1 0.29 6.37 0.33 6.14e-10 Longevity;Endometriosis; LUSC cis rs6424115 1.000 rs4649115 chr1:24155731 A/G cg10978503 chr1:24200527 CNR2 -0.51 -12.0 -0.55 7.98e-28 Immature fraction of reticulocytes; LUSC cis rs6964587 1.000 rs9969198 chr7:91567492 G/T cg17063962 chr7:91808500 NA -0.55 -8.63 -0.43 2.47e-16 Breast cancer; LUSC cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -8.78 -0.43 8.95e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504073 0.584 rs10957337 chr8:49959027 G/T cg00325661 chr8:49890786 NA 0.7 11.12 0.52 1.19e-24 Blood metabolite ratios; LUSC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -10.15 -0.49 2.92e-21 Developmental language disorder (linguistic errors); LUSC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg15556689 chr8:8085844 FLJ10661 0.57 8.8 0.43 7.62e-17 Myopia (pathological); LUSC cis rs765787 0.530 rs1706834 chr15:45517854 G/A cg24006582 chr15:45444508 DUOX1 -0.62 -9.07 -0.44 1.03e-17 Uric acid levels; LUSC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg23093090 chr10:104574429 C10orf26 0.34 6.51 0.34 2.71e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs4252134 0.959 rs4252093 chr6:161133685 A/G cg15416064 chr12:49209402 NA -0.43 -6.02 -0.31 4.47e-9 Giant cell arteritis; LUSC cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs76878669 0.561 rs2279861 chr11:66133336 A/G cg24851651 chr11:66362959 CCS -0.36 -5.74 -0.3 2.17e-8 Educational attainment (years of education); LUSC cis rs7647973 0.593 rs62262730 chr3:49808274 T/G cg13072238 chr3:49761600 GMPPB 0.68 8.57 0.42 4.02e-16 Menarche (age at onset); LUSC cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg18252515 chr7:66147081 NA -0.56 -7.71 -0.39 1.44e-13 Corneal structure; LUSC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.77 -0.35 5.74e-11 Alzheimer's disease (late onset); LUSC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg13047869 chr3:10149882 C3orf24 0.56 8.01 0.4 1.93e-14 Alzheimer's disease; LUSC cis rs2190422 0.651 rs2965086 chr7:103084913 C/T cg04218035 chr7:103086829 SLC26A5 0.31 6.08 0.32 3.21e-9 Morning vs. evening chronotype; LUSC cis rs2439831 0.850 rs524417 chr15:43772374 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.97 11.06 0.52 2.02e-24 Lung cancer in ever smokers; LUSC cis rs7605827 0.930 rs11694485 chr2:15676154 C/T cg19274914 chr2:15703543 NA 0.45 8.67 0.43 1.88e-16 Educational attainment (years of education); LUSC cis rs4803468 0.967 rs11083619 chr19:41913267 A/C cg09537434 chr19:41945824 ATP5SL -0.9 -15.71 -0.65 4.81e-42 Height; LUSC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg07701084 chr6:150067640 NUP43 0.55 8.45 0.42 9.18e-16 Lung cancer; LUSC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg03433033 chr1:76189801 ACADM 0.72 9.47 0.46 5.43e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10782582 0.593 rs11589276 chr1:76105545 G/A cg03433033 chr1:76189801 ACADM -0.48 -7.33 -0.37 1.8e-12 Daytime sleep phenotypes; LUSC trans rs2288327 0.591 rs2255167 chr2:179558282 T/A cg14011486 chr1:26737247 LIN28 0.52 6.61 0.34 1.51e-10 Atrial fibrillation; LUSC cis rs3092073 1.000 rs3092073 chr20:44595649 G/A cg27529037 chr20:44575021 PCIF1 -0.35 -6.06 -0.31 3.69e-9 Intelligence (multi-trait analysis); LUSC trans rs6030 1.000 rs1557572 chr1:169508576 A/C cg25052156 chr10:123355454 FGFR2 0.32 5.95 0.31 6.8e-9 Uric acid levels; LUSC trans rs6498114 0.541 rs72770017 chr16:10973612 G/A cg03103192 chr4:52917271 SPATA18 0.33 6.0 0.31 5.02e-9 Nasopharyngeal carcinoma; LUSC cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg16405210 chr4:1374714 KIAA1530 -0.55 -8.48 -0.42 7.39e-16 Obesity-related traits; LUSC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg04455712 chr21:45112962 RRP1B 0.45 8.46 0.42 8.63e-16 Mean corpuscular volume; LUSC cis rs7523273 0.606 rs2796271 chr1:207941927 A/G cg22525895 chr1:207977042 MIR29B2 0.42 6.72 0.35 7.81e-11 Schizophrenia; LUSC cis rs9633740 1.000 rs7910643 chr10:82251769 G/A cg01528321 chr10:82214614 TSPAN14 1.09 12.1 0.55 3.36e-28 Post bronchodilator FEV1; LUSC trans rs12310956 0.532 rs11052948 chr12:33981973 T/C cg13010199 chr12:38710504 ALG10B 0.56 8.42 0.42 1.12e-15 Morning vs. evening chronotype; LUSC cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14240646 chr10:27532245 ACBD5 -0.66 -7.91 -0.4 3.77e-14 Breast cancer; LUSC cis rs9527 0.590 rs11191553 chr10:104851396 G/T cg04362960 chr10:104952993 NT5C2 0.62 9.77 0.47 5.41e-20 Arsenic metabolism; LUSC cis rs2070997 0.667 rs12156431 chr9:133719540 A/G cg11464064 chr9:133710261 ABL1 0.48 5.68 0.3 2.97e-8 Response to amphetamines; LUSC cis rs6500395 0.962 rs2101372 chr16:48627306 G/A cg04672837 chr16:48644449 N4BP1 0.49 7.06 0.36 9.81e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg25036284 chr2:26402008 FAM59B -0.68 -9.58 -0.46 2.22e-19 Gut microbiome composition (summer); LUSC cis rs6690583 0.623 rs6679539 chr1:85479457 G/T cg11262906 chr1:85462892 MCOLN2 -0.66 -6.66 -0.34 1.14e-10 Serum sulfate level; LUSC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs727505 1.000 rs66922607 chr7:124512555 T/A cg23710748 chr7:124431027 NA -0.42 -7.42 -0.38 1e-12 Lewy body disease; LUSC cis rs929354 0.772 rs1182444 chr7:157024510 A/G cg05182265 chr7:156933206 UBE3C 0.6 9.74 0.47 6.75e-20 Body mass index; LUSC cis rs2486288 0.656 rs2271438 chr15:45557468 A/G cg26924012 chr15:45694286 SPATA5L1 -0.72 -10.6 -0.5 8.24e-23 Glomerular filtration rate; LUSC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg26566898 chr11:117069891 TAGLN 0.47 8.3 0.41 2.56e-15 Blood protein levels; LUSC cis rs6940638 0.688 rs9393791 chr6:27132529 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -5.74 -0.3 2.07e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg25036284 chr2:26402008 FAM59B -0.71 -10.01 -0.48 8.54e-21 Gut microbiome composition (summer); LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg13047869 chr3:10149882 C3orf24 0.64 8.61 0.43 2.98e-16 Alzheimer's disease; LUSC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg20203395 chr5:56204925 C5orf35 0.41 6.14 0.32 2.36e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg07217954 chr7:1067459 C7orf50 0.53 5.77 0.3 1.83e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4689388 0.926 rs3889821 chr4:6282596 C/T cg00701064 chr4:6280414 WFS1 0.62 15.62 0.65 1.16e-41 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs72781680 0.898 rs12619525 chr2:23999565 G/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs2204008 0.563 rs2320512 chr12:38266913 G/A cg26384229 chr12:38710491 ALG10B -0.57 -8.49 -0.42 6.96e-16 Bladder cancer; LUSC cis rs2204008 0.630 rs12306932 chr12:38242029 C/T cg13010199 chr12:38710504 ALG10B -0.46 -6.92 -0.35 2.37e-11 Bladder cancer; LUSC cis rs314370 0.951 rs12705095 chr7:100484381 T/G cg10426581 chr7:100472382 SRRT 0.86 12.48 0.56 1.36e-29 Resting heart rate; LUSC cis rs7940866 0.838 rs10750455 chr11:130800330 C/T cg12179176 chr11:130786555 SNX19 0.64 9.97 0.48 1.16e-20 Schizophrenia; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg06877462 chr1:205807181 PM20D1 0.49 8.82 0.43 6.26e-17 Menarche (age at onset); LUSC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg06112835 chr11:68658793 MRPL21 0.52 7.83 0.39 6.4e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10761482 0.813 rs2061487 chr10:62102842 T/C cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs10911251 0.528 rs2147584 chr1:183074764 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.67 0.5 4.62e-23 Colorectal cancer; LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg25072359 chr17:41440525 NA 0.65 9.21 0.45 3.66e-18 Menopause (age at onset); LUSC cis rs60843830 1.000 rs2126129 chr2:212548 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.62 9.88 0.48 2.23e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs12545109 0.765 rs1960727 chr8:57411368 G/A cg09654669 chr8:57350985 NA -0.52 -6.66 -0.34 1.11e-10 Obesity-related traits; LUSC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg08847533 chr14:75593920 NEK9 -0.81 -14.58 -0.62 1.31e-37 Height; LUSC cis rs9311676 0.632 rs67904096 chr3:58365508 T/A cg26110898 chr3:58419937 PDHB 0.44 7.22 0.37 3.62e-12 Systemic lupus erythematosus; LUSC cis rs950881 0.932 rs3771180 chr2:102953617 G/T cg20060108 chr2:102954350 IL1RL1 0.45 5.9 0.31 8.86e-9 Allergy; LUSC cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg01256987 chr12:42539512 GXYLT1 -0.46 -8.61 -0.43 2.88e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg12751644 chr20:60527061 NA 0.41 6.98 0.36 1.6e-11 Obesity-related traits; LUSC cis rs12421382 0.636 rs34802147 chr11:109380008 C/T cg27471124 chr11:109292789 C11orf87 0.36 6.49 0.33 3.17e-10 Schizophrenia; LUSC cis rs17253792 0.822 rs13379342 chr14:56050452 A/G cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs2398893 0.774 rs3909256 chr9:96889505 C/T cg14459158 chr9:96720562 NA -0.34 -6.05 -0.31 3.87e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs738322 0.934 rs133019 chr22:38573035 A/G cg25457927 chr22:38595422 NA -0.44 -9.11 -0.45 7.93e-18 Cutaneous nevi; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.55 -8.29 -0.41 2.85e-15 Lymphocyte counts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03158666 chr17:7199744 NA 0.46 6.03 0.31 4.32e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs73198271 0.562 rs76702427 chr8:8660141 G/T cg01851573 chr8:8652454 MFHAS1 0.65 8.7 0.43 1.49e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg25048357 chr11:118955763 HMBS 0.48 5.99 0.31 5.39e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.23 0.37 3.38e-12 Gut microbiome composition (summer); LUSC cis rs9650315 0.866 rs4601281 chr8:57182353 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.34 0.33 7.34e-10 Height; LUSC trans rs1459104 0.714 rs1851614 chr11:54836269 C/T cg15704280 chr7:45808275 SEPT13 0.77 6.69 0.34 9.32e-11 Body mass index; LUSC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg22800045 chr5:56110881 MAP3K1 0.44 6.26 0.32 1.18e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs9311676 0.656 rs9881869 chr3:58333255 G/A cg13750441 chr3:58318267 PXK -0.31 -5.88 -0.31 1.01e-8 Systemic lupus erythematosus; LUSC cis rs62400317 0.859 rs2038765 chr6:45076494 A/G cg18551225 chr6:44695536 NA -0.41 -6.81 -0.35 4.56e-11 Total body bone mineral density; LUSC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg21918786 chr6:109611834 NA -0.42 -7.31 -0.37 1.99e-12 Reticulocyte fraction of red cells; LUSC cis rs10751667 0.961 rs7482484 chr11:927020 C/T cg06064525 chr11:970664 AP2A2 -0.36 -7.17 -0.37 4.88e-12 Alzheimer's disease (late onset); LUSC cis rs9303401 0.659 rs61291849 chr17:56909867 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.35 0.59 7.08e-33 Cognitive test performance; LUSC trans rs6502050 0.871 rs6502054 chr17:80066715 G/A cg07393940 chr7:158741817 NA -0.36 -6.46 -0.33 3.76e-10 Life satisfaction; LUSC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9790314 0.846 rs4560315 chr3:160982132 G/T cg03342759 chr3:160939853 NMD3 -0.57 -9.81 -0.47 4.11e-20 Morning vs. evening chronotype; LUSC cis rs17685 0.712 rs10271413 chr7:75754858 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.89 -0.4 4.48e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg05472934 chr7:22766657 IL6 0.41 6.39 0.33 5.49e-10 Lung cancer; LUSC cis rs61931739 0.534 rs11052986 chr12:34052578 T/C cg06521331 chr12:34319734 NA -0.49 -8.11 -0.41 9.94e-15 Morning vs. evening chronotype; LUSC trans rs1994089 0.781 rs7215469 chr17:33510235 G/A cg25602930 chr2:9533887 ASAP2 0.43 6.42 0.33 4.81e-10 Macrophage inflammatory protein 1b levels; LUSC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg24642844 chr7:1081250 C7orf50 -0.51 -7.95 -0.4 2.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg19318889 chr4:1322082 MAEA 0.47 7.68 0.39 1.78e-13 Obesity-related traits; LUSC cis rs10779751 0.734 rs2791648 chr1:11132638 G/T cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs12474201 0.894 rs4952842 chr2:46925730 C/A cg06386533 chr2:46925753 SOCS5 0.79 12.1 0.55 3.33e-28 Height; LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg17178900 chr1:205818956 PM20D1 0.42 5.79 0.3 1.66e-8 Menarche (age at onset); LUSC cis rs3806843 0.576 rs246045 chr5:140329884 C/T cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.36e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs7647973 0.626 rs11709734 chr3:49745235 G/A cg21659725 chr3:3221576 CRBN -0.65 -7.77 -0.39 9.77e-14 Menarche (age at onset); LUSC cis rs3750965 0.920 rs4930644 chr11:68819097 C/T cg06818126 chr11:68850279 TPCN2 -0.45 -6.3 -0.33 9.46e-10 Hair color; LUSC cis rs11971779 0.680 rs7799598 chr7:139051833 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg25282410 chr6:160211355 TCP1;MRPL18 1.2 22.43 0.78 1.32e-68 Age-related macular degeneration (geographic atrophy); LUSC cis rs2625529 0.775 rs35673773 chr15:72399886 C/A cg16672083 chr15:72433130 SENP8 -0.52 -7.64 -0.39 2.26e-13 Red blood cell count; LUSC cis rs9926296 0.624 rs1110331 chr16:89774396 A/G cg03605463 chr16:89740564 NA 0.38 6.01 0.31 4.83e-9 Vitiligo; LUSC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg08975724 chr8:8085496 FLJ10661 0.53 8.17 0.41 6.57e-15 Mood instability; LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.09 0.55 3.85e-28 Prudent dietary pattern; LUSC cis rs10208940 0.920 rs6714976 chr2:68764873 G/T cg12452813 chr2:68675892 NA 0.58 5.96 0.31 6.45e-9 Urate levels in lean individuals; LUSC cis rs637571 0.522 rs528736 chr11:65705108 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.05 0.44 1.19e-17 Eosinophil percentage of white cells; LUSC cis rs2413583 0.591 rs116136126 chr22:39729557 T/C cg17798944 chr22:39715225 SNORD43;RPL3 0.63 5.76 0.3 1.96e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs703842 0.739 rs701008 chr12:58117645 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.47 6.32 0.33 8.35e-10 Multiple sclerosis; LUSC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg00033643 chr7:134001901 SLC35B4 0.43 6.6 0.34 1.59e-10 Mean platelet volume; LUSC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg21782813 chr7:2030301 MAD1L1 0.54 9.4 0.46 9.01e-19 Bipolar disorder and schizophrenia; LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.06 0.66 2.05e-43 Platelet count; LUSC trans rs877282 0.898 rs11253341 chr10:765008 G/C cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.95e-10 Uric acid levels; LUSC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.39e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg03709012 chr19:19516395 GATAD2A 0.84 14.32 0.62 1.33e-36 Tonsillectomy; LUSC cis rs501916 0.833 rs10519143 chr15:48055567 T/G cg16110827 chr15:48056943 SEMA6D -0.47 -7.33 -0.37 1.74e-12 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7824557 0.872 rs2572417 chr8:11111462 A/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.98 -0.31 5.8e-9 Retinal vascular caliber; LUSC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -11.55 -0.53 3.36e-26 Mean corpuscular volume; LUSC cis rs6690583 0.573 rs61768854 chr1:85460021 T/C cg11262906 chr1:85462892 MCOLN2 0.69 6.27 0.32 1.13e-9 Serum sulfate level; LUSC cis rs9790314 1.000 rs6441373 chr3:161026717 T/G cg03342759 chr3:160939853 NMD3 -0.5 -8.39 -0.42 1.43e-15 Morning vs. evening chronotype; LUSC cis rs4845570 0.834 rs1196467 chr1:151710038 T/C cg07092448 chr1:151763213 TDRKH 1.05 11.46 0.53 7.17e-26 Coronary artery disease; LUSC cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.54 0.5 1.28e-22 Schizophrenia; LUSC cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg03517284 chr6:25882590 NA -0.46 -8.83 -0.44 5.81e-17 Blood metabolite levels; LUSC cis rs1577917 0.958 rs11754330 chr6:86455070 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.85 -0.44 5.09e-17 Response to antipsychotic treatment; LUSC cis rs763121 0.925 rs5757165 chr22:38994577 C/T cg06022373 chr22:39101656 GTPBP1 0.79 13.13 0.58 4.83e-32 Menopause (age at onset); LUSC trans rs1493916 1.000 rs7238717 chr18:31395186 C/T cg15819921 chr19:927150 ARID3A -0.42 -6.15 -0.32 2.2e-9 Life satisfaction; LUSC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.44e-10 Extrinsic epigenetic age acceleration; LUSC cis rs11190604 1.000 rs10883502 chr10:102238343 T/G cg07080220 chr10:102295463 HIF1AN 0.64 8.46 0.42 8.25e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg12310025 chr6:25882481 NA -0.46 -7.85 -0.39 5.67e-14 Intelligence (multi-trait analysis); LUSC cis rs10464366 1.000 rs10464366 chr7:39121500 A/T cg20302533 chr7:39170763 POU6F2 -0.42 -6.09 -0.32 3.12e-9 IgG glycosylation; LUSC cis rs73200209 0.744 rs11616043 chr12:116559922 T/C cg01776926 chr12:116560359 MED13L -0.49 -6.01 -0.31 4.82e-9 Total body bone mineral density; LUSC trans rs853679 1.000 rs10456362 chr6:28221816 A/G cg01620082 chr3:125678407 NA 0.5 5.95 0.31 6.59e-9 Depression; LUSC cis rs6964587 1.000 rs13231578 chr7:91663266 C/T cg01689657 chr7:91764605 CYP51A1 0.31 5.79 0.3 1.63e-8 Breast cancer; LUSC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.07 -0.36 9.2e-12 Alzheimer's disease (late onset); LUSC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.45 0.33 3.86e-10 Menopause (age at onset); LUSC cis rs11864453 0.786 rs1050362 chr16:72130815 C/A cg23815491 chr16:72088622 HP 0.34 5.97 0.31 6.12e-9 Fibrinogen levels; LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg21770322 chr7:97807741 LMTK2 0.4 6.84 0.35 3.82e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs11650494 0.908 rs73340392 chr17:47358308 G/A cg08112188 chr17:47440006 ZNF652 1.19 10.13 0.48 3.41e-21 Prostate cancer; LUSC cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs931127 0.719 rs2127507 chr11:65454430 A/G cg05805236 chr11:65401703 PCNXL3 -0.42 -7.3 -0.37 2.13e-12 Systemic lupus erythematosus; LUSC cis rs11756438 0.572 rs902779 chr6:119000593 A/C cg21191810 chr6:118973309 C6orf204 0.33 5.73 0.3 2.21e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg02475777 chr4:1388615 CRIPAK 0.43 6.36 0.33 6.48e-10 Obesity-related traits; LUSC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg08677398 chr8:58056175 NA 0.54 6.65 0.34 1.23e-10 Developmental language disorder (linguistic errors); LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10465746 0.935 rs12410617 chr1:84379461 G/C cg10977910 chr1:84465055 TTLL7 0.43 6.18 0.32 1.88e-9 Obesity-related traits; LUSC cis rs10392 0.543 rs4812336 chr20:37547374 G/A cg27552599 chr20:37590471 DHX35 0.44 6.94 0.36 2.03e-11 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.22 -0.45 3.35e-18 Bipolar disorder; LUSC trans rs11098499 0.687 rs71610270 chr4:120287436 A/G cg25214090 chr10:38739885 LOC399744 0.5 7.64 0.39 2.31e-13 Corneal astigmatism; LUSC cis rs981844 0.961 rs56288418 chr4:154668228 C/A cg14289246 chr4:154710475 SFRP2 0.48 6.1 0.32 2.87e-9 Response to statins (LDL cholesterol change); LUSC cis rs4423214 0.879 rs1790330 chr11:71147825 C/T cg05163923 chr11:71159392 DHCR7 -0.7 -9.2 -0.45 4.07e-18 Vitamin D levels; LUSC cis rs73206853 0.563 rs7960749 chr12:111164369 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.52 0.38 5.1e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2348418 0.864 rs1343859 chr12:28712470 A/G cg13890972 chr12:28721907 NA -0.34 -5.82 -0.3 1.39e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs9462027 0.585 rs1201873 chr6:34550657 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.06 -0.31 3.73e-9 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10541313 chr22:46663664 TTC38 -0.4 -6.06 -0.31 3.59e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1832871 0.711 rs9459769 chr6:158666493 T/C cg07165851 chr6:158734300 TULP4 0.5 7.61 0.38 2.81e-13 Height; LUSC cis rs9300255 0.722 rs10846515 chr12:123801672 T/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -5.77 -0.3 1.85e-8 Neutrophil percentage of white cells; LUSC trans rs3733585 0.673 rs9994937 chr4:9964799 G/T cg26043149 chr18:55253948 FECH -0.46 -7.07 -0.36 9.1e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4474465 1.000 rs7124043 chr11:78205644 G/T cg27205649 chr11:78285834 NARS2 0.51 5.91 0.31 8.55e-9 Alzheimer's disease (survival time); LUSC cis rs7666738 0.546 rs10025064 chr4:98914060 A/G cg17366294 chr4:99064904 C4orf37 0.52 8.55 0.42 4.5e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg09367891 chr1:107599246 PRMT6 -0.49 -7.81 -0.39 7.31e-14 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs4285028 0.948 rs7615571 chr3:121665950 A/C cg11130432 chr3:121712080 ILDR1 -0.63 -9.61 -0.47 1.89e-19 Multiple sclerosis; LUSC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg13206674 chr6:150067644 NUP43 0.6 9.58 0.46 2.27e-19 Lung cancer; LUSC cis rs2742234 0.541 rs11528481 chr10:43737767 C/A cg02780029 chr10:43622663 RET 0.35 5.79 0.3 1.6e-8 Hirschsprung disease; LUSC trans rs72674100 1.000 rs4308366 chr4:97972932 G/C cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs56283067 0.887 rs12215971 chr6:44784566 A/G cg20913747 chr6:44695427 NA -0.43 -6.46 -0.33 3.6e-10 Total body bone mineral density; LUSC cis rs1190552 0.637 rs7150548 chr14:102959962 T/C cg18135206 chr14:102964638 TECPR2 0.53 5.81 0.3 1.42e-8 Blood protein levels; LUSC cis rs722599 0.715 rs2080086 chr14:75338408 G/A cg08847533 chr14:75593920 NEK9 -0.46 -6.54 -0.34 2.34e-10 IgG glycosylation; LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg11645453 chr3:52864694 ITIH4 0.37 8.61 0.43 2.99e-16 Bipolar disorder; LUSC cis rs1577917 0.655 rs2842600 chr6:86325632 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.48 -7.52 -0.38 4.96e-13 Response to antipsychotic treatment; LUSC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg21017887 chr14:105400489 NA 0.7 13.31 0.59 9.7e-33 Rheumatoid arthritis; LUSC cis rs4280164 0.830 rs2144494 chr14:24773387 T/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.57 -6.81 -0.35 4.43e-11 Parent of origin effect on language impairment (paternal); LUSC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg03929089 chr4:120376271 NA -1.03 -20.21 -0.74 7.12e-60 Height; LUSC cis rs3135063 0.504 rs3129315 chr4:3290600 C/T cg08817983 chr4:3391423 RGS12 -0.51 -6.92 -0.35 2.27e-11 Blood protein levels; LUSC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg22166914 chr1:53195759 ZYG11B 0.56 9.03 0.44 1.44e-17 Monocyte count; LUSC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg19318889 chr4:1322082 MAEA 0.48 7.83 0.39 6.69e-14 Obesity-related traits; LUSC cis rs9300255 0.602 rs2695476 chr12:123694206 T/C cg00376283 chr12:123451042 ABCB9 0.7 7.93 0.4 3.22e-14 Neutrophil percentage of white cells; LUSC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.48 -6.15 -0.32 2.21e-9 Mean platelet volume; LUSC cis rs3099143 0.908 rs3102716 chr15:77051003 T/G cg21673338 chr15:77095150 SCAPER -0.84 -8.24 -0.41 4.05e-15 Recalcitrant atopic dermatitis; LUSC trans rs11098499 0.779 rs10011097 chr4:120310359 T/G cg25214090 chr10:38739885 LOC399744 0.54 7.98 0.4 2.36e-14 Corneal astigmatism; LUSC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg02475777 chr4:1388615 CRIPAK 0.37 5.65 0.3 3.46e-8 Obesity-related traits; LUSC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg15813090 chr5:442598 EXOC3;C5orf55 0.44 7.18 0.37 4.51e-12 Cystic fibrosis severity; LUSC cis rs2742234 0.590 rs2257767 chr10:43657811 T/G cg15436174 chr10:43711423 RASGEF1A -0.44 -7.06 -0.36 9.53e-12 Hirschsprung disease; LUSC cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.24 0.45 3.06e-18 Motion sickness; LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -11.1 -0.52 1.45e-24 Alzheimer's disease; LUSC cis rs7804356 1.000 rs3801823 chr7:26861031 T/C cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs79149102 0.579 rs12591994 chr15:75320306 A/G cg09165964 chr15:75287851 SCAMP5 -0.92 -8.15 -0.41 7.37e-15 Lung cancer; LUSC cis rs2742417 1.000 rs2673033 chr3:45756350 C/G cg09608765 chr3:45636137 LIMD1 -0.36 -7.17 -0.37 4.9e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg26441486 chr22:50317300 CRELD2 0.49 7.28 0.37 2.45e-12 Schizophrenia; LUSC cis rs9513627 1.000 rs9585075 chr13:100128634 G/A cg25919922 chr13:100150906 NA -0.75 -6.44 -0.33 4.11e-10 Obesity-related traits; LUSC cis rs453301 0.686 rs28482034 chr8:8869664 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -7.72 -0.39 1.37e-13 Joint mobility (Beighton score); LUSC cis rs11711311 0.911 rs9817327 chr3:113478500 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.41 -5.65 -0.3 3.48e-8 IgG glycosylation; LUSC cis rs2070488 0.775 rs11926767 chr3:38527913 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.68 -11.8 -0.54 4.21e-27 Electrocardiographic conduction measures; LUSC cis rs12410462 0.581 rs7541809 chr1:227547299 G/A cg23173402 chr1:227635558 NA 0.56 6.34 0.33 7.53e-10 Major depressive disorder; LUSC cis rs2625529 0.824 rs11072339 chr15:72247190 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.51 -0.38 5.28e-13 Red blood cell count; LUSC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg25124228 chr12:125621409 AACS -0.48 -7.14 -0.36 6e-12 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.81 -0.7 2.33e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs1322512 1.000 rs2758776 chr6:153006317 C/T cg27316956 chr6:152958899 SYNE1 0.34 5.98 0.31 5.72e-9 Tonometry; LUSC cis rs3213545 0.700 rs2260399 chr12:121469653 C/T cg02403541 chr12:121454288 C12orf43 0.56 8.66 0.43 2e-16 Subjective well-being;Cardiovascular disease risk factors; LUSC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.36 0.53 1.61e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6783573 0.510 rs11718490 chr3:46628763 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.42 -6.87 -0.35 3.2e-11 Cerebrospinal fluid biomarker levels; LUSC trans rs11098499 0.954 rs10006877 chr4:120242793 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.17 0.32 1.99e-9 Corneal astigmatism; LUSC cis rs5758511 0.680 rs1107553 chr22:42667473 A/G cg00645731 chr22:42541494 CYP2D7P1 0.59 10.28 0.49 9.88e-22 Birth weight; LUSC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg08439880 chr3:133502540 NA -0.4 -7.16 -0.36 5.05e-12 Iron status biomarkers; LUSC cis rs929354 0.605 rs7806314 chr7:156946903 A/T cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC cis rs62400317 0.859 rs62436779 chr6:45124911 G/A cg20913747 chr6:44695427 NA -0.47 -7.55 -0.38 4.27e-13 Total body bone mineral density; LUSC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg21724239 chr8:58056113 NA 0.78 8.17 0.41 6.56e-15 Developmental language disorder (linguistic errors); LUSC cis rs17685 0.672 rs6465011 chr7:75811297 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.48 -7.16 -0.36 5.07e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2294693 0.945 rs9369253 chr6:40986538 A/G cg14769373 chr6:40998127 UNC5CL -0.58 -8.06 -0.4 1.39e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg16325326 chr1:53192061 ZYG11B -0.82 -14.27 -0.62 2.19e-36 Monocyte count; LUSC cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.5 -0.34 2.95e-10 Monocyte percentage of white cells; LUSC cis rs73206853 0.563 rs7960761 chr12:111164415 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.35 0.37 1.52e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs62103177 0.564 rs3930043 chr18:77723832 G/A cg14227996 chr4:17616232 MED28 0.64 6.84 0.35 3.71e-11 Opioid sensitivity; LUSC cis rs2262909 0.745 rs1989120 chr19:22205528 T/C cg11619707 chr19:22235551 ZNF257 -0.38 -5.79 -0.3 1.66e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs62400317 0.859 rs12191751 chr6:45282111 G/T cg20913747 chr6:44695427 NA -0.46 -7.44 -0.38 8.87e-13 Total body bone mineral density; LUSC cis rs295140 0.605 rs1436164 chr2:201158411 C/T cg04283868 chr2:201171347 SPATS2L 0.4 5.8 0.3 1.55e-8 QT interval; LUSC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg02569458 chr12:86230093 RASSF9 0.6 10.0 0.48 8.96e-21 Major depressive disorder; LUSC cis rs9790314 1.000 rs9870059 chr3:161017240 T/C cg03342759 chr3:160939853 NMD3 -0.5 -8.5 -0.42 6.49e-16 Morning vs. evening chronotype; LUSC cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18470468 chr7:98985742 ARPC1B -0.8 -6.9 -0.35 2.58e-11 Cognitive performance; LUSC trans rs11098499 0.863 rs13140409 chr4:120503460 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.0 0.4 2.12e-14 Corneal astigmatism; LUSC cis rs6938 0.618 rs2044157 chr15:75225808 G/C cg17294928 chr15:75287854 SCAMP5 0.43 6.19 0.32 1.72e-9 Breast cancer; LUSC cis rs62408225 0.963 rs55885254 chr6:90976234 T/C cg06866423 chr6:90926672 BACH2 0.42 5.96 0.31 6.26e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg05043794 chr9:111880884 C9orf5 -0.38 -7.97 -0.4 2.47e-14 Menarche (age at onset); LUSC cis rs3020736 0.500 rs6002603 chr22:42492362 C/G cg04733989 chr22:42467013 NAGA -0.62 -9.65 -0.47 1.39e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs6964587 0.869 rs6975243 chr7:91514672 G/A cg17063962 chr7:91808500 NA -0.51 -7.89 -0.4 4.24e-14 Breast cancer; LUSC cis rs926938 0.765 rs12407408 chr1:115234275 A/G cg12756093 chr1:115239321 AMPD1 0.48 7.08 0.36 8.4e-12 Autism; LUSC cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg05347473 chr6:146136440 FBXO30 0.53 8.95 0.44 2.54e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs908922 0.887 rs4596895 chr1:152528075 T/G cg20991723 chr1:152506922 NA 0.51 8.8 0.43 7.56e-17 Hair morphology; LUSC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg00166722 chr3:10149974 C3orf24 -0.39 -5.98 -0.31 5.7e-9 Alzheimer's disease; LUSC cis rs721399 0.512 rs4560828 chr8:18276294 A/T cg18736775 chr8:18248649 NAT2 -0.56 -6.58 -0.34 1.82e-10 Blood metabolite levels; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg27284194 chr4:1044797 NA 0.35 5.69 0.3 2.73e-8 Longevity; LUSC cis rs7523050 0.643 rs7551313 chr1:109399881 G/A cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC cis rs4253772 0.550 rs9615347 chr22:46728153 A/G cg00784671 chr22:46762841 CELSR1 -0.5 -5.92 -0.31 7.92e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs9875589 0.509 rs1906538 chr3:14014169 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.38 6.7 0.34 8.74e-11 Ovarian reserve; LUSC cis rs870825 0.860 rs60523653 chr4:185604676 T/C cg04058563 chr4:185651563 MLF1IP 0.77 10.26 0.49 1.17e-21 Blood protein levels; LUSC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg27170947 chr2:26402098 FAM59B -0.7 -10.76 -0.51 2.21e-23 Gut microbiome composition (summer); LUSC trans rs194045 0.511 rs1611991 chr16:29151593 C/T cg17334114 chr3:133646504 NA 0.54 6.46 0.33 3.61e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs79349575 0.783 rs17635252 chr17:47006950 T/C cg22482690 chr17:47019901 SNF8 0.39 7.34 0.37 1.6e-12 Type 2 diabetes; LUSC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg27535305 chr1:53392650 SCP2 -0.4 -7.5 -0.38 5.74e-13 Monocyte count; LUSC cis rs11229555 0.598 rs12289876 chr11:58185250 C/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg24324837 chr19:49891574 CCDC155 0.55 7.71 0.39 1.5e-13 Multiple sclerosis; LUSC cis rs9790314 1.000 rs4597724 chr3:160963110 A/G cg03342759 chr3:160939853 NMD3 -0.47 -7.85 -0.39 5.79e-14 Morning vs. evening chronotype; LUSC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg16606324 chr3:10149918 C3orf24 0.44 6.77 0.35 5.91e-11 Alzheimer's disease; LUSC cis rs4794106 0.792 rs11365 chr17:48211533 T/G cg13893634 chr17:48229117 PPP1R9B -0.51 -7.78 -0.39 8.93e-14 Temporomandibular joint disorder; LUSC cis rs4077515 0.967 rs11794847 chr9:139271747 G/A cg14019695 chr9:139328340 INPP5E 0.44 8.12 0.41 8.86e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg13699009 chr12:122356056 WDR66 0.5 7.77 0.39 1e-13 Mean corpuscular volume; LUSC cis rs12318506 0.826 rs11180434 chr12:75662128 T/C cg04728562 chr12:75699417 CAPS2 -0.77 -5.93 -0.31 7.49e-9 Coronary artery calcification; LUSC cis rs11252926 0.797 rs61837235 chr10:489363 G/A cg16346588 chr10:242978 ZMYND11 -0.46 -6.02 -0.31 4.53e-9 Psychosis in Alzheimer's disease; LUSC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.29 0.33 1e-9 Height; LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.92 0.68 7.95e-47 Gut microbiome composition (summer); LUSC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.55 0.62 1.76e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10883723 0.669 rs2001595 chr10:104395085 C/T cg05855489 chr10:104503620 C10orf26 -0.63 -8.18 -0.41 6.14e-15 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg18876405 chr7:65276391 NA 0.68 12.15 0.55 2.13e-28 Aortic root size; LUSC cis rs4803468 1.000 rs284654 chr19:41928724 G/A cg09537434 chr19:41945824 ATP5SL -0.94 -16.34 -0.67 1.61e-44 Height; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg22907277 chr7:1156413 C7orf50 0.64 10.18 0.49 2.28e-21 Longevity;Endometriosis; LUSC cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.05 -0.36 1.02e-11 Colorectal cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20789464 chr11:85565977 CCDC83 0.43 6.26 0.32 1.17e-9 Triglycerides; LUSC trans rs7937682 0.883 rs549143 chr11:111463779 C/T cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs9674544 0.757 rs11871214 chr17:47124902 G/T cg10950924 chr17:47092072 IGF2BP1 -0.37 -5.71 -0.3 2.53e-8 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); LUSC cis rs9355610 0.892 rs2247314 chr6:167370230 T/C cg23791538 chr6:167370224 RNASET2 0.51 8.52 0.42 5.74e-16 Graves' disease; LUSC cis rs929354 1.000 rs1182452 chr7:157053618 G/A cg17757837 chr7:157058334 UBE3C -0.92 -15.6 -0.65 1.37e-41 Body mass index; LUSC cis rs4792901 0.918 rs12103666 chr17:41636310 G/A cg22562494 chr17:41607896 ETV4 -0.28 -5.65 -0.3 3.44e-8 Dupuytren's disease; LUSC cis rs2652834 0.851 rs2729778 chr15:63407332 T/G cg05507819 chr15:63340323 TPM1 0.47 6.0 0.31 5.26e-9 HDL cholesterol; LUSC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.37 5.85 0.3 1.17e-8 Lymphocyte counts; LUSC cis rs9326248 0.581 rs7120515 chr11:116991926 A/G cg16524733 chr11:117070046 TAGLN 0.32 6.0 0.31 5.05e-9 Blood protein levels; LUSC cis rs240764 0.610 rs41288423 chr6:101166095 G/A cg09795085 chr6:101329169 ASCC3 -0.42 -6.09 -0.32 3.03e-9 Neuroticism; LUSC trans rs1256061 0.874 rs12435857 chr14:64723525 G/A cg07874507 chr10:24503148 KIAA1217 0.34 6.0 0.31 5.24e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs12249377 0.519 rs4520504 chr10:92602373 T/C cg14313238 chr10:92632228 RPP30 0.43 5.96 0.31 6.36e-9 White matter microstructure (global fractional anisotropy); LUSC trans rs7647973 0.710 rs11130207 chr3:49611666 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 6.98e-13 Menarche (age at onset); LUSC cis rs3806843 1.000 rs7732179 chr5:140199039 G/A cg03975922 chr5:140080575 ZMAT2 0.32 5.68 0.3 2.88e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs2281845 0.560 rs12079819 chr1:201085420 G/A cg06714761 chr1:201096289 NA 0.37 6.88 0.35 3e-11 Permanent tooth development; LUSC cis rs9467773 0.620 rs2504592 chr6:26640951 C/G cg05738196 chr6:26577821 NA 0.78 14.99 0.63 3.4e-39 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.67 -8.84 -0.44 5.49e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7264396 0.887 rs6060431 chr20:34059337 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.52 -0.34 2.58e-10 Total cholesterol levels; LUSC cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg17042849 chr6:26104293 HIST1H4C -0.66 -8.16 -0.41 6.69e-15 Iron status biomarkers; LUSC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg22529645 chr1:3704559 LRRC47 0.36 6.41 0.33 4.99e-10 Red cell distribution width; LUSC cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg13256891 chr4:100009986 ADH5 0.49 6.79 0.35 5.04e-11 Smoking initiation; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg26668828 chr6:292823 DUSP22 -0.72 -12.17 -0.55 1.83e-28 Menopause (age at onset); LUSC trans rs6011368 0.840 rs6062361 chr20:62904542 C/T cg13869341 chr1:15865 WASH5P -0.43 -6.77 -0.35 5.72e-11 Clozapine-induced cytotoxicity; LUSC cis rs77633900 0.614 rs2629021 chr15:76974083 C/T cg21673338 chr15:77095150 SCAPER -0.8 -8.15 -0.41 7.48e-15 Non-glioblastoma glioma;Glioma; LUSC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg25287198 chr4:183728479 NA 0.56 7.88 0.4 4.73e-14 Pediatric autoimmune diseases; LUSC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.83 12.68 0.57 2.41e-30 IgG glycosylation; LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg27535305 chr1:53392650 SCP2 0.36 6.78 0.35 5.33e-11 Monocyte count; LUSC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg00677455 chr12:58241039 CTDSP2 0.5 7.49 0.38 6.04e-13 Intelligence (multi-trait analysis); LUSC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg02423579 chr7:2872169 GNA12 -0.47 -6.53 -0.34 2.46e-10 Height; LUSC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.7 0.51 3.69e-23 Hip circumference adjusted for BMI; LUSC cis rs5167 0.743 rs8111069 chr19:45483438 A/C cg20090143 chr19:45452003 APOC2 0.35 5.94 0.31 7.21e-9 Blood protein levels; LUSC cis rs1451375 0.572 rs12666409 chr7:50634976 A/T cg18232548 chr7:50535776 DDC -0.48 -6.4 -0.33 5.39e-10 Malaria; LUSC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg22467129 chr15:76604101 ETFA -0.51 -8.26 -0.41 3.38e-15 Blood metabolite levels; LUSC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg18876405 chr7:65276391 NA 0.55 8.56 0.42 4.15e-16 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19587038 chr1:46598331 PIK3R3 0.47 6.72 0.35 7.73e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.53 -7.22 -0.37 3.6e-12 Renal function-related traits (BUN); LUSC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 15.41 0.64 7.23e-41 Platelet count; LUSC cis rs3820928 1.000 rs7561378 chr2:227772248 T/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.84 -0.39 5.96e-14 Pulmonary function; LUSC cis rs2797160 1.000 rs1954361 chr6:126001423 C/G cg05901451 chr6:126070800 HEY2 -0.58 -8.59 -0.43 3.43e-16 Endometrial cancer; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs60843830 0.633 rs1078763 chr2:113763 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.43 -6.59 -0.34 1.74e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1908814 0.510 rs57655799 chr8:11782417 A/C cg21775007 chr8:11205619 TDH 0.46 6.67 0.34 1.09e-10 Neuroticism; LUSC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs11098499 0.954 rs6838814 chr4:120392443 G/A cg24375607 chr4:120327624 NA 0.78 11.49 0.53 5.51e-26 Corneal astigmatism; LUSC cis rs807669 0.527 rs11089259 chr22:19190143 C/T cg02655711 chr22:19163373 SLC25A1 0.69 12.61 0.57 4.43e-30 Metabolite levels; LUSC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg04369109 chr6:150039330 LATS1 -0.52 -7.43 -0.38 8.98e-13 Lung cancer; LUSC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg04733989 chr22:42467013 NAGA 0.62 9.75 0.47 6.31e-20 Schizophrenia; LUSC cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg07606381 chr6:8435919 SLC35B3 0.73 12.55 0.57 7.07e-30 Motion sickness; LUSC cis rs2070488 0.965 rs1058945 chr3:38532511 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.76 -14.55 -0.62 1.71e-37 Electrocardiographic conduction measures; LUSC trans rs1994135 0.647 rs66542958 chr12:33695385 T/G cg13010199 chr12:38710504 ALG10B 0.53 7.34 0.37 1.65e-12 Resting heart rate; LUSC cis rs11252926 0.510 rs4881371 chr10:554514 G/A cg03684893 chr10:554711 DIP2C -0.45 -8.52 -0.42 5.64e-16 Psychosis in Alzheimer's disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07477187 chr1:155243300 CLK2 0.7 6.09 0.32 3.08e-9 Cognitive performance; LUSC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg17330251 chr7:94953956 PON1 -0.38 -6.12 -0.32 2.62e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg01528321 chr10:82214614 TSPAN14 0.62 9.08 0.45 9.41e-18 Post bronchodilator FEV1; LUSC cis rs4474465 0.688 rs7927494 chr11:78280578 G/A cg27205649 chr11:78285834 NARS2 0.55 6.77 0.35 5.66e-11 Alzheimer's disease (survival time); LUSC cis rs2816316 1.000 rs1323298 chr1:192519865 T/C cg02586212 chr1:192544902 RGS1 0.32 5.87 0.31 1.04e-8 Celiac disease; LUSC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg02527881 chr3:46936655 PTH1R 0.41 7.25 0.37 2.93e-12 Colorectal cancer; LUSC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg03517284 chr6:25882590 NA -0.46 -7.77 -0.39 9.61e-14 Intelligence (multi-trait analysis); LUSC cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg23992470 chr4:843637 GAK 0.61 6.56 0.34 2.1e-10 Intelligence (multi-trait analysis); LUSC cis rs12210905 0.688 rs12191373 chr6:27484330 C/T cg08851530 chr6:28072375 NA 0.9 6.03 0.31 4.25e-9 Hip circumference adjusted for BMI; LUSC cis rs17270561 0.525 rs12201678 chr6:25978993 C/T cg17691542 chr6:26056736 HIST1H1C 1.03 13.2 0.59 2.7e-32 Iron status biomarkers; LUSC cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg20848291 chr7:100343083 ZAN 0.68 9.38 0.46 1e-18 Other erythrocyte phenotypes; LUSC cis rs4851254 0.961 rs6713524 chr2:100747357 A/G cg07810366 chr2:100720526 AFF3 -0.37 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs10782582 0.632 rs77099976 chr1:76240524 T/C cg10523679 chr1:76189770 ACADM -0.43 -6.06 -0.31 3.66e-9 Daytime sleep phenotypes; LUSC cis rs7178572 0.568 rs1565757 chr15:77657682 C/T cg22256960 chr15:77711686 NA -0.49 -7.9 -0.4 4.02e-14 Type 2 diabetes; LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.32 0.53 2.29e-25 Menopause (age at onset); LUSC trans rs3808502 0.525 rs13280813 chr8:11425105 G/T cg15556689 chr8:8085844 FLJ10661 -0.63 -9.49 -0.46 4.37e-19 Neuroticism; LUSC cis rs3808502 0.605 rs11784572 chr8:11174484 C/G cg21775007 chr8:11205619 TDH -0.68 -10.04 -0.48 6.64e-21 Neuroticism; LUSC trans rs6952808 0.692 rs6950627 chr7:2086672 C/T cg04565464 chr8:145669602 NFKBIL2 0.39 6.35 0.33 7.22e-10 Bipolar disorder and schizophrenia; LUSC cis rs6456156 0.526 rs3093025 chr6:167532731 A/G cg07741184 chr6:167504864 NA -0.51 -9.17 -0.45 5.1e-18 Primary biliary cholangitis; LUSC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg03929089 chr4:120376271 NA 0.95 15.19 0.64 5.71e-40 Coronary artery disease; LUSC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg11235426 chr6:292522 DUSP22 -0.42 -6.05 -0.31 3.97e-9 Menopause (age at onset); LUSC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 7.04 0.36 1.11e-11 Multiple sclerosis; LUSC cis rs1451375 0.669 rs10274172 chr7:50637575 G/A cg18232548 chr7:50535776 DDC -0.5 -7.6 -0.38 3.11e-13 Malaria; LUSC trans rs12902680 0.632 rs12440590 chr15:46585511 G/A cg04321580 chr8:143696133 ARC -0.4 -6.04 -0.31 4.18e-9 Neuroticism; LUSC cis rs11098499 0.909 rs28668716 chr4:120309875 T/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg06484146 chr7:12443880 VWDE -0.68 -7.06 -0.36 9.43e-12 Coronary artery disease; LUSC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC trans rs9380880 0.826 rs9380882 chr6:39547428 A/T cg19893670 chr10:60097505 UBE2D1 0.65 5.96 0.31 6.24e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs2730245 0.636 rs2657382 chr7:158650941 G/A cg24397884 chr7:158709396 WDR60 0.6 9.28 0.45 2.2e-18 Height; LUSC cis rs9807989 0.507 rs10200952 chr2:103027651 A/C cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.69e-12 Asthma; LUSC cis rs6500602 0.826 rs9925719 chr16:4461861 A/G cg08645402 chr16:4508243 NA 0.48 7.18 0.37 4.53e-12 Schizophrenia; LUSC cis rs16976116 0.901 rs28591259 chr15:55498940 T/A cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs13196614 0.756 rs9485317 chr6:149018295 G/A cg01343097 chr1:248284971 OR2M1P 0.41 6.04 0.31 4e-9 Migraine; LUSC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg14552801 chr7:65878734 NA 0.37 5.66 0.3 3.2e-8 Aortic root size; LUSC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg01416388 chr22:39784598 NA -0.44 -7.24 -0.37 3.17e-12 Intelligence (multi-trait analysis); LUSC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg08847533 chr14:75593920 NEK9 -0.85 -15.52 -0.65 2.7e-41 Height; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg21280719 chr6:42927975 GNMT -0.31 -7.85 -0.39 5.85e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2658782 0.724 rs2248020 chr11:93259965 A/C cg15737290 chr11:93063684 CCDC67 0.56 7.17 0.37 4.77e-12 Pulmonary function decline; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg22166914 chr1:53195759 ZYG11B 0.5 8.25 0.41 3.81e-15 Monocyte count; LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.56 0.65 1.98e-41 Platelet count; LUSC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg22800045 chr5:56110881 MAP3K1 0.77 9.63 0.47 1.5700000000000001e-19 Initial pursuit acceleration; LUSC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg20203395 chr5:56204925 C5orf35 -0.78 -10.4 -0.49 4.07e-22 Initial pursuit acceleration; LUSC cis rs11608355 0.545 rs35590455 chr12:109893514 A/G cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg02807482 chr3:125708958 NA -0.54 -6.69 -0.34 9.15e-11 Blood pressure (smoking interaction); LUSC cis rs12618769 0.597 rs17446058 chr2:99164160 A/G cg10123293 chr2:99228465 UNC50 0.46 7.35 0.37 1.49e-12 Bipolar disorder; LUSC cis rs7100689 0.725 rs10749574 chr10:82136856 T/C cg01528321 chr10:82214614 TSPAN14 1.01 15.61 0.65 1.22e-41 Post bronchodilator FEV1; LUSC cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.71 0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs3892630 0.817 rs12609866 chr19:33184412 C/T cg22980127 chr19:33182716 NUDT19 0.95 12.94 0.58 2.44e-31 Red blood cell traits; LUSC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg27427491 chr17:78079615 GAA 0.38 6.62 0.34 1.45e-10 Yeast infection; LUSC cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs7267979 1.000 rs6050562 chr20:25336186 C/G cg08601574 chr20:25228251 PYGB -0.44 -6.8 -0.35 4.71e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24160036 chr20:55966451 RBM38 -0.43 -6.21 -0.32 1.55e-9 Electrocardiographic conduction measures; LUSC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg23791538 chr6:167370224 RNASET2 -0.37 -5.72 -0.3 2.38e-8 Crohn's disease; LUSC cis rs9815354 0.812 rs73081361 chr3:41912535 G/A cg03022575 chr3:42003672 ULK4 0.83 8.67 0.43 1.88e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6456156 0.586 rs7762156 chr6:167485831 A/T cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg13390004 chr1:15929781 NA 0.43 7.31 0.37 1.94e-12 Systolic blood pressure; LUSC trans rs208520 0.661 rs207090 chr6:66783963 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.23 -0.69 4.77e-48 Exhaled nitric oxide output; LUSC cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.69 -0.3 2.75e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg00129232 chr17:37814104 STARD3 -0.49 -7.32 -0.37 1.91e-12 Asthma; LUSC trans rs1325195 0.881 rs10913690 chr1:179067071 G/T cg11624085 chr17:8464688 MYH10 -0.41 -6.63 -0.34 1.34e-10 IgE grass sensitization; LUSC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg12310025 chr6:25882481 NA -0.46 -7.86 -0.4 5.19e-14 Intelligence (multi-trait analysis); LUSC cis rs1712517 0.873 rs1891292 chr10:105001510 A/G cg05636881 chr10:105038444 INA -0.39 -6.46 -0.33 3.61e-10 Migraine; LUSC cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg03146154 chr1:46216737 IPP 0.54 8.12 0.41 8.97e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs9409565 0.762 rs60964095 chr9:97175774 G/T cg05679027 chr9:99775184 HIATL2 -0.48 -6.81 -0.35 4.59e-11 Colorectal cancer (alcohol consumption interaction); LUSC cis rs854765 0.552 rs11078407 chr17:17841083 T/C cg16928487 chr17:17741425 SREBF1 -0.43 -8.62 -0.43 2.81e-16 Total body bone mineral density; LUSC cis rs34779708 0.966 rs4934540 chr10:35474699 T/C cg03585969 chr10:35415529 CREM 0.64 9.5 0.46 4.29e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9467711 0.722 rs13201782 chr6:26651053 T/A cg09904177 chr6:26538194 HMGN4 -0.8 -5.92 -0.31 7.81e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2816062 0.735 rs2816054 chr1:18896431 C/T cg18795169 chr1:18902165 NA -1.01 -24.69 -0.8 2.52e-77 Urate levels in lean individuals; LUSC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg07936489 chr17:37558343 FBXL20 0.72 10.21 0.49 1.79e-21 Glomerular filtration rate (creatinine); LUSC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.92 0.35 2.25e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8060686 0.545 rs3815173 chr16:68160289 T/G cg09835421 chr16:68378352 PRMT7 -0.61 -6.38 -0.33 5.77e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs3617 0.573 rs9860296 chr3:52913781 A/G cg18404041 chr3:52824283 ITIH1 -0.36 -6.15 -0.32 2.21e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs6964587 1.000 rs7781066 chr7:91691946 G/T cg22709100 chr7:91322751 NA 0.39 5.79 0.3 1.67e-8 Breast cancer; LUSC cis rs17213078 0.510 rs17032713 chr2:106886839 T/C cg15412446 chr2:106886593 NA -0.47 -6.74 -0.35 6.88e-11 Facial morphology (factor 23); LUSC cis rs381815 1.000 rs448671 chr11:16900103 T/G cg05701403 chr11:16947551 PLEKHA7 0.38 5.77 0.3 1.78e-8 Diastolic blood pressure;Systolic blood pressure;Blood pressure; LUSC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.41 -5.65 -0.3 3.39e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg17633681 chr16:88106987 BANP 0.5 9.19 0.45 4.32e-18 Menopause (age at onset); LUSC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg27539214 chr16:67997921 SLC12A4 -0.53 -6.42 -0.33 4.58e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.576 rs7660951 chr4:98651581 T/A cg03676636 chr4:99064102 C4orf37 0.3 5.96 0.31 6.35e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg02153584 chr22:29168773 CCDC117 0.59 8.99 0.44 1.84e-17 Lymphocyte counts; LUSC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg09021430 chr5:549028 NA -0.56 -7.67 -0.39 1.85e-13 Obesity-related traits; LUSC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg07414643 chr4:187882934 NA 0.56 10.64 0.5 5.99e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs9549367 0.713 rs56002882 chr13:113830694 T/C cg18105134 chr13:113819100 PROZ -0.74 -10.34 -0.49 6.21e-22 Platelet distribution width; LUSC trans rs7824557 0.843 rs2736375 chr8:11115749 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.54 -0.42 4.96e-16 Retinal vascular caliber; LUSC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg13939156 chr17:80058883 NA -0.32 -6.38 -0.33 5.99e-10 Life satisfaction; LUSC cis rs10761482 0.500 rs2211220 chr10:62271491 A/G cg18175470 chr10:62150864 ANK3 -0.42 -5.97 -0.31 6.14e-9 Schizophrenia; LUSC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg11766577 chr21:47581405 C21orf56 -0.54 -8.08 -0.4 1.19e-14 Testicular germ cell tumor; LUSC cis rs4268898 0.862 rs11125549 chr2:24576240 C/T cg06627628 chr2:24431161 ITSN2 0.62 9.22 0.45 3.54e-18 Asthma; LUSC cis rs11039100 0.850 rs11039121 chr11:5833161 T/C cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9303401 0.659 rs7225896 chr17:56637337 T/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.08 0.45 9.54e-18 Cognitive test performance; LUSC trans rs8002861 0.840 rs1819597 chr13:44429553 G/A cg12856521 chr11:46389249 DGKZ 0.4 6.37 0.33 6.37e-10 Leprosy; LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg10802521 chr3:52805072 NEK4 -0.56 -8.98 -0.44 2e-17 Bipolar disorder; LUSC cis rs12421382 0.778 rs11213128 chr11:109489575 G/A cg16359550 chr11:109292809 C11orf87 0.37 6.1 0.32 2.89e-9 Schizophrenia; LUSC cis rs7824557 0.767 rs2164273 chr8:11168499 A/G cg21293242 chr8:11204541 TDH 0.31 5.82 0.3 1.35e-8 Retinal vascular caliber; LUSC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs12310956 0.532 rs10506119 chr12:33963684 A/G cg06521331 chr12:34319734 NA -0.45 -7.21 -0.37 3.74e-12 Morning vs. evening chronotype; LUSC trans rs11098499 0.866 rs12510451 chr4:120289143 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs134594 1.000 rs134602 chr22:29473884 A/G cg03665785 chr22:29458676 C22orf31 0.28 5.75 0.3 2.04e-8 Birth weight; LUSC cis rs4654899 0.680 rs4233274 chr1:21121678 C/T cg01072550 chr1:21505969 NA -0.49 -7.17 -0.37 4.81e-12 Superior frontal gyrus grey matter volume; LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg09436375 chr6:42928200 GNMT -0.31 -7.09 -0.36 8.29e-12 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg05347473 chr6:146136440 FBXO30 -0.48 -7.93 -0.4 3.23e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs62064224 0.589 rs4132610 chr17:30801441 C/T cg18200150 chr17:30822561 MYO1D 0.31 5.9 0.31 8.71e-9 Schizophrenia; LUSC cis rs9660992 0.508 rs113817010 chr1:205104581 C/A cg21643547 chr1:205240462 TMCC2 -0.4 -7.3 -0.37 2.13e-12 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg04414720 chr1:150670196 GOLPH3L -0.49 -7.36 -0.37 1.48e-12 Blood protein levels; LUSC cis rs793571 0.544 rs12912699 chr15:58917021 T/C cg05156742 chr15:59063176 FAM63B 0.54 8.32 0.41 2.25e-15 Schizophrenia; LUSC cis rs10886558 0.502 rs4752376 chr10:121830185 C/G cg02041677 chr10:121771263 NA 0.31 5.68 0.3 2.98e-8 Shingles; LUSC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg08219700 chr8:58056026 NA 0.67 6.27 0.32 1.12e-9 Developmental language disorder (linguistic errors); LUSC cis rs16854884 0.837 rs13062793 chr3:143808387 A/G cg06585982 chr3:143692056 C3orf58 0.43 6.27 0.32 1.14e-9 Economic and political preferences (feminism/equality); LUSC cis rs7917772 0.582 rs7907760 chr10:104345197 C/T cg05855489 chr10:104503620 C10orf26 -0.49 -7.47 -0.38 7.25e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg24110177 chr3:50126178 RBM5 0.65 11.57 0.53 2.85e-26 Body mass index; LUSC cis rs10492096 0.947 rs61918022 chr12:6614521 C/T cg13857086 chr12:6580257 VAMP1 0.6 7.07 0.36 9.06e-12 Hip geometry; LUSC cis rs3784262 1.000 rs4646638 chr15:58248783 C/T cg12031962 chr15:58353849 ALDH1A2 0.31 5.8 0.3 1.51e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs7827545 0.960 rs1372661 chr8:135566859 A/G cg17885191 chr8:135476712 NA 0.57 8.55 0.42 4.4e-16 Hypertension (SNP x SNP interaction); LUSC cis rs7586879 0.765 rs10171663 chr2:25086431 T/C cg04586622 chr2:25135609 ADCY3 0.3 5.66 0.3 3.32e-8 Body mass index; LUSC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg04315214 chr1:2043799 PRKCZ -0.39 -7.74 -0.39 1.18e-13 Height; LUSC cis rs9039 1.000 rs1128001 chr16:9207003 T/C cg08831531 chr16:9218945 NA -0.66 -10.43 -0.5 3.11e-22 Menopause (age at onset); LUSC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg03806693 chr22:41940476 POLR3H 0.88 12.16 0.55 2.07e-28 Vitiligo; LUSC cis rs6964587 1.000 rs7797369 chr7:91570615 C/A cg22709100 chr7:91322751 NA -0.38 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs9300255 0.539 rs1969355 chr12:123742061 G/A cg00376283 chr12:123451042 ABCB9 0.7 9.83 0.47 3.33e-20 Neutrophil percentage of white cells; LUSC cis rs17253792 0.822 rs9972180 chr14:56073732 G/T cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.9e-12 Putamen volume; LUSC cis rs11098499 0.739 rs9884728 chr4:120127079 C/T cg24375607 chr4:120327624 NA -0.69 -10.81 -0.51 1.47e-23 Corneal astigmatism; LUSC cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg14784868 chr12:69753453 YEATS4 -0.59 -8.5 -0.42 6.31e-16 Blood protein levels; LUSC cis rs7833986 0.501 rs2719255 chr8:57036658 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.15 0.55 2.14e-28 Height; LUSC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg27165867 chr14:105738592 BRF1 -0.51 -7.41 -0.38 1.04e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 14.18 0.61 4.59e-36 Platelet count; LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs193541 0.507 rs56346354 chr5:122076344 G/A cg19077854 chr5:122220652 SNX24 0.28 6.02 0.31 4.53e-9 Glucose homeostasis traits; LUSC cis rs8044995 0.563 rs2279540 chr16:68395061 T/C cg05110241 chr16:68378359 PRMT7 -0.77 -8.71 -0.43 1.4e-16 Schizophrenia; LUSC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg04546413 chr19:29218101 NA 0.62 8.12 0.41 8.94e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg16325326 chr1:53192061 ZYG11B -0.88 -16.23 -0.66 4.3e-44 Monocyte count; LUSC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg26659404 chr1:25747437 RHCE -0.3 -6.4 -0.33 5.37e-10 Erythrocyte sedimentation rate; LUSC trans rs7615952 0.611 rs2971298 chr3:125602713 G/A cg07211511 chr3:129823064 LOC729375 -1.01 -12.65 -0.57 3.12e-30 Blood pressure (smoking interaction); LUSC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg15147215 chr3:52552868 STAB1 -0.3 -5.96 -0.31 6.55e-9 Bipolar disorder; LUSC cis rs1577917 0.958 rs4707229 chr6:86546237 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.83 -0.35 4.14e-11 Response to antipsychotic treatment; LUSC trans rs10435719 0.867 rs62493601 chr8:11788307 C/T cg15556689 chr8:8085844 FLJ10661 0.57 8.66 0.43 2.1e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9902453 0.817 rs880749 chr17:28059970 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -9.31 -0.45 1.71e-18 Coffee consumption (cups per day); LUSC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg10802521 chr3:52805072 NEK4 -0.54 -8.78 -0.43 8.4e-17 Bipolar disorder; LUSC trans rs28735056 0.967 rs11662248 chr18:77619009 C/T cg05926928 chr17:57297772 GDPD1 -0.47 -6.58 -0.34 1.83e-10 Schizophrenia; LUSC cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.72 -0.3 2.4e-8 Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs9622833 chr22:39000397 G/A cg06022373 chr22:39101656 GTPBP1 0.77 12.0 0.55 7.71e-28 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21378393 chr17:2239733 TSR1;SGSM2 -0.41 -5.99 -0.31 5.4e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg05425664 chr17:57184151 TRIM37 -0.56 -8.22 -0.41 4.62e-15 Intelligence (multi-trait analysis); LUSC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg11764359 chr7:65958608 NA -0.7 -10.63 -0.5 6.55e-23 Aortic root size; LUSC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg04518342 chr5:131593106 PDLIM4 0.45 8.44 0.42 9.6e-16 Breast cancer; LUSC cis rs10089 1.000 rs4836361 chr5:127459991 T/C cg19767477 chr5:127420684 SLC12A2 -0.43 -5.79 -0.3 1.64e-8 Ileal carcinoids; LUSC cis rs10100465 1.000 rs16890041 chr8:118665691 T/C cg09430518 chr8:118662568 NA -0.3 -5.68 -0.3 2.91e-8 Leprosy; LUSC cis rs2204008 0.805 rs4589389 chr12:37946120 C/A cg13010199 chr12:38710504 ALG10B -0.63 -9.81 -0.47 4.06e-20 Bladder cancer; LUSC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg04486885 chr5:176823424 SLC34A1 0.39 6.09 0.32 3.08e-9 Urinary electrolytes (magnesium/calcium ratio); LUSC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg24296786 chr1:45957014 TESK2 0.5 7.56 0.38 3.93e-13 High light scatter reticulocyte count; LUSC cis rs6964587 0.839 rs62466159 chr7:91450507 A/G cg22709100 chr7:91322751 NA 0.47 6.87 0.35 3.1e-11 Breast cancer; LUSC cis rs861020 0.630 rs655712 chr1:210006437 G/A cg05527609 chr1:210001259 C1orf107 0.67 9.63 0.47 1.5700000000000001e-19 Orofacial clefts; LUSC trans rs800082 0.799 rs9870285 chr3:144236432 C/A cg24215973 chr2:240111563 HDAC4 0.41 6.03 0.31 4.33e-9 Smoking behavior; LUSC cis rs1559088 0.947 rs10403238 chr19:33552405 A/G cg03563238 chr19:33554763 RHPN2 -0.41 -6.57 -0.34 1.92e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.54 8.13 0.41 8.56e-15 Axial length; LUSC cis rs2692947 0.832 rs2579519 chr2:96675166 T/C cg22654517 chr2:96458247 NA 0.35 6.99 0.36 1.47e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs16854884 0.586 rs13081286 chr3:143723757 A/T cg01302019 chr3:143689584 C3orf58 -0.34 -5.68 -0.3 2.96e-8 Economic and political preferences (feminism/equality); LUSC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg08677398 chr8:58056175 NA 0.53 6.36 0.33 6.53e-10 Developmental language disorder (linguistic errors); LUSC cis rs8060686 0.668 rs8046355 chr16:68205214 T/A cg05110241 chr16:68378359 PRMT7 -0.47 -6.07 -0.32 3.45e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs3733585 0.673 rs4292332 chr4:9953830 C/A cg26043149 chr18:55253948 FECH -0.45 -6.89 -0.35 2.86e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7824557 0.545 rs2572450 chr8:11229638 C/T cg08975724 chr8:8085496 FLJ10661 -0.5 -7.2 -0.37 3.93e-12 Retinal vascular caliber; LUSC trans rs62103177 0.713 rs3744886 chr18:77659561 G/T cg14227996 chr4:17616232 MED28 0.81 7.12 0.36 6.76e-12 Opioid sensitivity; LUSC cis rs478304 1.000 rs478304 chr11:65494260 G/T cg27068330 chr11:65405492 SIPA1 0.65 9.7 0.47 9.4e-20 Acne (severe); LUSC cis rs9875589 0.509 rs4685062 chr3:14066409 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.12 0.36 6.54e-12 Ovarian reserve; LUSC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs9300255 0.739 rs1402275 chr12:123750895 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.91e-9 Neutrophil percentage of white cells; LUSC cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg24209194 chr3:40518798 ZNF619 0.47 6.35 0.33 7.15e-10 Renal cell carcinoma; LUSC cis rs877282 0.842 rs12357963 chr10:757562 C/T cg17470449 chr10:769945 NA 0.52 6.97 0.36 1.72e-11 Uric acid levels; LUSC cis rs10754283 0.967 rs7519971 chr1:90108743 G/A cg21401794 chr1:90099060 LRRC8C 0.64 9.62 0.47 1.65e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg06022373 chr22:39101656 GTPBP1 0.78 12.23 0.56 1.11e-28 Menopause (age at onset); LUSC cis rs1385374 0.858 rs10773578 chr12:129290026 G/C cg09035930 chr12:129282057 SLC15A4 -0.64 -6.78 -0.35 5.5e-11 Systemic lupus erythematosus; LUSC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg15448220 chr1:150897856 SETDB1 -0.41 -6.14 -0.32 2.38e-9 Melanoma; LUSC cis rs28829049 0.597 rs71645438 chr1:19502349 G/A cg13387374 chr1:19411106 UBR4 0.44 6.23 0.32 1.39e-9 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.806 rs4075696 chr6:146250947 T/C cg23711669 chr6:146136114 FBXO30 -0.81 -14.85 -0.63 1.16e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg22709100 chr7:91322751 NA 0.39 5.82 0.3 1.38e-8 Breast cancer; LUSC cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg23093090 chr10:104574429 C10orf26 -0.37 -6.87 -0.35 3.08e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3820928 0.904 rs59135978 chr2:227857763 T/C cg11843606 chr2:227700838 RHBDD1 -0.51 -7.31 -0.37 1.99e-12 Pulmonary function; LUSC cis rs6967385 0.560 rs10434998 chr7:12348375 C/T cg10578991 chr7:12443926 VWDE 0.4 6.02 0.31 4.66e-9 Response to taxane treatment (placlitaxel); LUSC cis rs7106204 0.748 rs28656439 chr11:24207653 G/C ch.11.24196551F chr11:24239977 NA 1.1 13.51 0.59 1.75e-33 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.88 0.66 1.09e-42 Platelet count; LUSC cis rs12493885 0.725 rs11717851 chr3:153741735 G/A cg17054900 chr3:154042577 DHX36 -0.61 -6.63 -0.34 1.32e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7918232 0.662 rs10764662 chr10:27300643 T/A cg14240646 chr10:27532245 ACBD5 -0.48 -6.04 -0.31 4.14e-9 Breast cancer; LUSC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg26116260 chr4:7069785 GRPEL1 1.15 17.83 0.7 2.02e-50 Monocyte percentage of white cells; LUSC cis rs6696846 0.515 rs12136320 chr1:205110946 T/C cg00857998 chr1:205179979 DSTYK 0.47 6.68 0.34 9.82e-11 Red blood cell count; LUSC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg20503657 chr10:835505 NA 0.82 11.66 0.54 1.36e-26 Eosinophil percentage of granulocytes; LUSC cis rs1044826 0.692 rs176987 chr3:139233001 G/A cg00490450 chr3:139108681 COPB2 -0.46 -7.05 -0.36 1.05e-11 Obesity-related traits; LUSC cis rs4901869 0.966 rs425764 chr14:59334997 A/G cg02291164 chr14:59296302 NA 0.48 8.83 0.44 5.82e-17 Panic disorder; LUSC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg20821713 chr7:1055600 C7orf50 -0.57 -7.41 -0.38 1.01e-12 Bronchopulmonary dysplasia; LUSC cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg19628046 chr18:33552617 C18orf21 0.52 6.26 0.32 1.15e-9 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs9951602 0.541 rs7243702 chr18:76645637 G/A cg02800362 chr5:177631904 HNRNPAB 0.84 12.5 0.56 1.17e-29 Obesity-related traits; LUSC cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg00321850 chr1:175162397 KIAA0040 -0.45 -7.7 -0.39 1.53e-13 Alcohol dependence; LUSC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg09021430 chr5:549028 NA -0.54 -7.06 -0.36 9.57e-12 Lung disease severity in cystic fibrosis; LUSC cis rs8017423 0.845 rs8005870 chr14:90723172 A/C cg04374321 chr14:90722782 PSMC1 0.75 12.04 0.55 5.52e-28 Mortality in heart failure; LUSC cis rs1949733 1.000 rs2631740 chr4:8484106 C/A cg13073564 chr4:8508604 NA 0.46 8.62 0.43 2.79e-16 Response to antineoplastic agents; LUSC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg06238570 chr21:40685208 BRWD1 0.54 8.03 0.4 1.64e-14 Cognitive function; LUSC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg01579765 chr21:45077557 HSF2BP 0.55 11.77 0.54 5.58e-27 Mean corpuscular volume; LUSC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg17968037 chr7:100024898 ZCWPW1 -0.44 -6.21 -0.32 1.57e-9 Platelet count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23201549 chr2:43454852 ZFP36L2;LOC100129726 -0.43 -6.49 -0.33 3.14e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs950776 0.518 rs12906846 chr15:78825295 G/A cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg12165864 chr7:66369176 NA -0.53 -7.14 -0.36 5.77e-12 Corneal structure; LUSC cis rs6574644 1.000 rs6574642 chr14:81774316 A/G cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs6665290 0.669 rs3768421 chr1:227177193 G/A cg10327440 chr1:227177885 CDC42BPA -1.11 -28.57 -0.84 1.04e-91 Myeloid white cell count; LUSC cis rs8072548 1 rs8072548 chr17:38164025 T/G cg17467752 chr17:38218738 THRA 0.5 7.39 0.37 1.17e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.4 0.42 1.32e-15 Schizophrenia; LUSC cis rs3790645 0.831 rs873151 chr1:26880989 T/C cg17456097 chr1:26900765 RPS6KA1 0.43 6.22 0.32 1.47e-9 Glucose homeostasis traits; LUSC trans rs7726839 0.561 rs72703050 chr5:582917 A/C cg11887960 chr12:57824829 NA 0.48 6.47 0.33 3.46e-10 Obesity-related traits; LUSC cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs929354 1.000 rs929354 chr7:157045557 C/T cg17757837 chr7:157058334 UBE3C -0.76 -11.55 -0.53 3.57e-26 Body mass index; LUSC trans rs62103177 0.673 rs4438371 chr18:77615988 C/T cg05926928 chr17:57297772 GDPD1 1.11 13.96 0.61 3.39e-35 Opioid sensitivity; LUSC cis rs12188164 0.515 rs2672744 chr5:411047 A/G cg26850624 chr5:429559 AHRR 0.32 6.15 0.32 2.24e-9 Cystic fibrosis severity; LUSC cis rs72781680 0.846 rs72780108 chr2:23986780 G/A cg08917208 chr2:24149416 ATAD2B 0.85 9.66 0.47 1.22e-19 Lymphocyte counts; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg20690916 chr5:140700301 TAF7 0.76 6.8 0.35 4.89e-11 Cognitive performance; LUSC cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg01973587 chr1:228161476 NA 0.45 8.21 0.41 5.03e-15 Diastolic blood pressure; LUSC cis rs7216064 1.000 rs11079706 chr17:65835470 G/T cg12091567 chr17:66097778 LOC651250 -0.74 -9.32 -0.45 1.62e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.49 0.38 6.14e-13 Parkinson's disease; LUSC trans rs11700980 0.551 rs34161405 chr21:30113840 T/C cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.78e-9 QRS complex (12-leadsum); LUSC cis rs611744 0.507 rs2121900 chr8:109333542 T/C cg18478394 chr8:109455254 TTC35 0.45 6.53 0.34 2.45e-10 Dupuytren's disease; LUSC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.8 -0.35 4.91e-11 Menarche (age at onset); LUSC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg18252515 chr7:66147081 NA -1.25 -13.99 -0.61 2.56e-35 Diabetic kidney disease; LUSC cis rs6142102 0.961 rs8119937 chr20:32645551 C/T cg08999081 chr20:33150536 PIGU 0.34 5.9 0.31 8.81e-9 Skin pigmentation; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00837290 chr16:89350068 ANKRD11 0.4 6.14 0.32 2.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3540 0.512 rs3862434 chr15:91080387 C/T cg22089800 chr15:90895588 ZNF774 0.65 10.19 0.49 2.09e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs2235649 0.798 rs9932875 chr16:1848012 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.1 -0.32 2.93e-9 Blood metabolite levels; LUSC cis rs3771570 0.901 rs6757876 chr2:242245570 T/C cg21155796 chr2:242212141 HDLBP 0.56 6.77 0.35 5.72e-11 Prostate cancer; LUSC cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -6.98 -0.36 1.63e-11 Colorectal cancer; LUSC trans rs7824557 0.778 rs6601572 chr8:11093337 C/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.2 -0.41 5.22e-15 Retinal vascular caliber; LUSC cis rs72772090 0.539 rs56120748 chr5:96110622 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.75 -7.64 -0.39 2.26e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4919044 1.000 rs17108042 chr10:94770488 A/C cg00519463 chr10:94352821 KIF11 0.65 5.64 0.3 3.57e-8 Coronary artery disease; LUSC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg18190219 chr22:46762943 CELSR1 -0.59 -6.2 -0.32 1.65e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.54 9.01 0.44 1.6e-17 Prudent dietary pattern; LUSC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.84 0.47 3.1e-20 Major depressive disorder; LUSC trans rs10506458 1.000 rs12425932 chr12:63410497 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -16.23 -0.66 4.58e-44 Hemostatic factors and hematological phenotypes; LUSC cis rs240764 0.658 rs7747014 chr6:101201898 T/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.35 -0.33 6.85e-10 Neuroticism; LUSC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg12963246 chr6:28129442 ZNF389 0.45 6.07 0.32 3.44e-9 Parkinson's disease; LUSC cis rs3754214 0.823 rs494041 chr1:150270026 T/C cg15654264 chr1:150340011 RPRD2 -0.45 -7.4 -0.38 1.09e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg12963246 chr6:28129442 ZNF389 0.51 7.06 0.36 9.81e-12 Depression; LUSC cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.42 -6.41 -0.33 4.96e-10 Menarche (age at onset); LUSC cis rs73200209 0.744 rs58471589 chr12:116573035 A/C cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs7106204 0.534 rs76397001 chr11:24254188 A/C ch.11.24196551F chr11:24239977 NA 0.72 6.09 0.32 3.05e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1538970 0.961 rs4660854 chr1:45854087 A/T cg06784218 chr1:46089804 CCDC17 0.31 5.69 0.3 2.74e-8 Platelet count; LUSC cis rs6939532 0.517 rs733528 chr6:26374903 A/G cg09904177 chr6:26538194 HMGN4 -0.45 -6.39 -0.33 5.46e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs11214589 0.719 rs10891535 chr11:113201280 C/G cg14159747 chr11:113255604 NA 0.26 6.54 0.34 2.34e-10 Neuroticism; LUSC cis rs9905704 0.552 rs8071623 chr17:56621286 G/T cg19466818 chr17:56409534 MIR142 0.35 6.54 0.34 2.31e-10 Testicular germ cell tumor; LUSC cis rs5769707 0.568 rs2011097 chr22:50018069 A/G cg05373962 chr22:49881684 NA -0.41 -8.76 -0.43 1.01e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs56161922 0.908 rs55952744 chr1:207860158 C/G cg11752769 chr1:207818423 CR1L -0.7 -5.91 -0.31 8.43e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04232541 chr6:144384895 PLAGL1 0.37 6.51 0.34 2.81e-10 Triglycerides; LUSC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg23283495 chr1:209979779 IRF6 0.73 9.34 0.46 1.37e-18 Cleft lip with or without cleft palate; LUSC cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg08330031 chr10:104623503 C10orf32 0.33 6.02 0.31 4.7e-9 Arsenic metabolism; LUSC cis rs17826219 0.568 rs2626985 chr17:29077437 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.07 0.36 8.86e-12 Body mass index; LUSC trans rs7829975 0.846 rs7005216 chr8:8547110 C/G cg27411982 chr8:10470053 RP1L1 -0.38 -6.0 -0.31 5.19e-9 Mood instability; LUSC trans rs10506458 0.834 rs55966529 chr12:63384114 A/C cg22491629 chr6:157744540 C6orf35 -0.87 -10.55 -0.5 1.22e-22 Hemostatic factors and hematological phenotypes; LUSC cis rs13082711 0.911 rs2371065 chr3:27494589 A/C cg02860705 chr3:27208620 NA 0.49 7.94 0.4 3.03e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.71 0.34 8.3e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7224314 1.000 rs8075952 chr17:65381358 C/T cg01507342 chr17:65387096 PITPNC1 -0.44 -7.87 -0.4 4.95e-14 Diisocyanate-induced asthma; LUSC cis rs5769765 1.000 rs34774661 chr22:50267508 C/G cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs394563 0.591 rs237018 chr6:149743930 A/G cg11245181 chr6:149772854 ZC3H12D -0.29 -6.35 -0.33 7.12e-10 Dupuytren's disease; LUSC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.39 0.56 2.97e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg04352962 chr1:209979756 IRF6 0.51 6.12 0.32 2.69e-9 Cleft lip with or without cleft palate; LUSC cis rs826838 0.967 rs826855 chr12:39114888 T/C cg13010199 chr12:38710504 ALG10B -0.63 -10.87 -0.51 9.13e-24 Heart rate; LUSC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg15556689 chr8:8085844 FLJ10661 -0.58 -8.89 -0.44 3.93e-17 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg21535247 chr6:8435926 SLC35B3 0.58 9.07 0.44 1.06e-17 Motion sickness; LUSC trans rs853679 1.000 rs13200462 chr6:28218199 A/C cg06606381 chr12:133084897 FBRSL1 -0.58 -6.68 -0.34 9.77e-11 Depression; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg13758310 chr4:1834493 LETM1 0.51 7.25 0.37 2.92e-12 Cognitive function;Information processing speed; LUSC cis rs7119 0.717 rs12911854 chr15:77817288 T/C cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs6012953 0.654 rs6067471 chr20:49127282 A/C cg13958625 chr20:49123093 NA 0.27 5.75 0.3 2.02e-8 Vitiligo; LUSC cis rs9926296 0.656 rs4522419 chr16:89853307 T/C cg26513180 chr16:89883248 FANCA 0.61 9.08 0.44 9.64e-18 Vitiligo; LUSC cis rs897080 0.552 rs1067384 chr2:44644554 G/A cg00619915 chr2:44497795 NA -0.41 -5.84 -0.3 1.27e-8 Height; LUSC cis rs7590368 0.779 rs3856465 chr2:10916670 C/T cg15705551 chr2:10952987 PDIA6 0.48 6.38 0.33 6.06e-10 Educational attainment (years of education); LUSC cis rs6754311 0.552 rs1030765 chr2:136553188 A/T cg07169764 chr2:136633963 MCM6 -0.61 -7.99 -0.4 2.24e-14 Mosquito bite size; LUSC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg09455208 chr3:40491958 NA 0.57 9.87 0.48 2.41e-20 Renal cell carcinoma; LUSC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg09034736 chr1:150693464 HORMAD1 -0.4 -5.73 -0.3 2.29e-8 Tonsillectomy; LUSC cis rs66887589 0.720 rs11724758 chr4:120239878 G/A cg24375607 chr4:120327624 NA 0.52 8.16 0.41 7.07e-15 Diastolic blood pressure; LUSC trans rs3942852 1.000 rs3942852 chr11:48115089 C/T cg03929089 chr4:120376271 NA -0.54 -6.18 -0.32 1.89e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.47 0.38 6.86e-13 Menarche (age at onset); LUSC cis rs4319547 0.656 rs10773088 chr12:122828069 A/T cg23029597 chr12:123009494 RSRC2 -0.74 -9.38 -0.46 1.03e-18 Body mass index; LUSC cis rs61931739 0.517 rs1843735 chr12:34047389 C/G cg06521331 chr12:34319734 NA -0.49 -8.13 -0.41 8.54e-15 Morning vs. evening chronotype; LUSC cis rs559928 0.597 rs2186572 chr11:63895887 A/G cg05555928 chr11:63887634 MACROD1 -0.49 -6.18 -0.32 1.87e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2289328 0.823 rs35565646 chr15:40660515 G/A cg13931752 chr15:40660718 DISP2 0.46 6.46 0.33 3.64e-10 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs2860975 1.000 rs11492718 chr10:96787377 A/T cg09036531 chr10:96991505 NA -0.41 -5.75 -0.3 2.06e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs1448094 0.933 rs11836175 chr12:86311644 A/T cg02569458 chr12:86230093 RASSF9 0.44 6.96 0.36 1.77e-11 Major depressive disorder; LUSC cis rs3760982 1.000 rs4803658 chr19:44290013 T/A cg11993925 chr19:44307056 LYPD5 0.28 6.26 0.32 1.18e-9 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.86 -0.35 3.41e-11 Lung cancer; LUSC cis rs2285947 1.000 rs10229224 chr7:21583921 G/A cg04471919 chr7:21584483 DNAH11 0.34 7.73 0.39 1.29e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC trans rs7615952 0.599 rs12486459 chr3:125741465 T/G cg07211511 chr3:129823064 LOC729375 -0.78 -9.97 -0.48 1.18e-20 Blood pressure (smoking interaction); LUSC cis rs10875746 0.903 rs17122666 chr12:48502574 C/T cg13454099 chr12:49076203 C12orf41 -0.52 -6.02 -0.31 4.69e-9 Longevity (90 years and older); LUSC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg04518342 chr5:131593106 PDLIM4 0.34 6.18 0.32 1.92e-9 Blood metabolite levels; LUSC cis rs7917772 0.582 rs10786687 chr10:104336994 A/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2625529 0.730 rs3759900 chr15:72451827 A/C cg16672083 chr15:72433130 SENP8 0.47 7.59 0.38 3.27e-13 Red blood cell count; LUSC cis rs9650657 0.683 rs7836366 chr8:10585683 A/G cg14992524 chr8:10586135 SOX7 -0.35 -6.24 -0.32 1.32e-9 Neuroticism; LUSC cis rs7216064 0.953 rs4791300 chr17:65930772 A/G cg12091567 chr17:66097778 LOC651250 -0.72 -9.56 -0.46 2.67e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7927771 0.524 rs2170815 chr11:47875910 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.76 0.35 6.07e-11 Subjective well-being; LUSC cis rs727505 1.000 rs3925331 chr7:124446137 C/G cg23710748 chr7:124431027 NA -0.41 -7.32 -0.37 1.89e-12 Lewy body disease; LUSC cis rs11190604 1.000 rs4919470 chr10:102298920 C/T cg07080220 chr10:102295463 HIF1AN 0.69 8.73 0.43 1.2e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg12257692 chr3:49977190 RBM6 -0.26 -7.2 -0.37 3.93e-12 Intelligence (multi-trait analysis); LUSC cis rs11711311 0.911 rs9831422 chr3:113398195 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.94 -0.31 7.28e-9 IgG glycosylation; LUSC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg07636037 chr3:49044803 WDR6 1.09 19.01 0.72 3.83e-55 Parkinson's disease; LUSC cis rs2806561 0.704 rs2868573 chr1:23508253 C/G cg19743168 chr1:23544995 NA 0.41 7.96 0.4 2.75e-14 Height; LUSC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.68 0.34 9.94e-11 Systemic lupus erythematosus; LUSC cis rs68170813 0.559 rs58663672 chr7:106949444 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.66 -0.47 1.27e-19 Coronary artery disease; LUSC cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg19628046 chr18:33552617 C18orf21 -0.56 -6.79 -0.35 5.03e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg00990874 chr7:1149470 C7orf50 -0.5 -6.02 -0.31 4.72e-9 Bronchopulmonary dysplasia; LUSC cis rs1577917 1.000 rs10498958 chr6:86649705 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 8.34 0.42 2.01e-15 Response to antipsychotic treatment; LUSC cis rs4363385 0.818 rs419721 chr1:153006902 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.44e-8 Inflammatory skin disease; LUSC cis rs2573652 1.000 rs2727199 chr15:100514417 C/T cg09918751 chr15:100517450 ADAMTS17 -0.46 -8.59 -0.43 3.38e-16 Height; LUSC cis rs2204008 0.837 rs7301679 chr12:37989629 T/C cg26384229 chr12:38710491 ALG10B -0.81 -13.55 -0.6 1.28e-33 Bladder cancer; LUSC cis rs11250098 0.541 rs6997839 chr8:10766028 T/C cg27411982 chr8:10470053 RP1L1 -0.46 -6.82 -0.35 4.23e-11 Morning vs. evening chronotype; LUSC cis rs1957429 0.901 rs17102320 chr14:65384693 T/C cg23373153 chr14:65346875 NA -1.04 -11.35 -0.53 1.85e-25 Pediatric areal bone mineral density (radius); LUSC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.75e-10 Crohn's disease; LUSC cis rs208520 0.690 rs12213928 chr6:66762978 G/A cg07460842 chr6:66804631 NA 1.1 17.21 0.69 5.97e-48 Exhaled nitric oxide output; LUSC cis rs9905704 1.000 rs9905704 chr17:56632543 G/T cg12560992 chr17:57184187 TRIM37 -0.55 -7.79 -0.39 8.29e-14 Testicular germ cell tumor; LUSC cis rs4900538 0.855 rs1190537 chr14:102887816 C/T cg18135206 chr14:102964638 TECPR2 -0.99 -19.0 -0.72 4.38e-55 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7824557 0.527 rs4631425 chr8:11239054 C/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.8 -0.3 1.56e-8 Retinal vascular caliber; LUSC cis rs77633900 0.772 rs283799 chr15:76752834 A/C cg21673338 chr15:77095150 SCAPER -0.72 -6.24 -0.32 1.33e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs34421088 0.532 rs3808515 chr8:11156041 C/T cg21775007 chr8:11205619 TDH 0.47 6.87 0.35 3.08e-11 Neuroticism; LUSC cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.86 -0.35 3.32e-11 Monocyte percentage of white cells; LUSC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg03433033 chr1:76189801 ACADM 0.81 14.39 0.62 6.93e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg24209194 chr3:40518798 ZNF619 0.49 6.42 0.33 4.63e-10 Renal cell carcinoma; LUSC cis rs11992162 0.569 rs11786149 chr8:11800818 G/A cg21775007 chr8:11205619 TDH -0.42 -5.71 -0.3 2.47e-8 Monocyte count; LUSC cis rs9650315 0.659 rs60698069 chr8:57206322 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.33 0.37 1.73e-12 Height; LUSC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.82 0.39 7.1e-14 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg01579765 chr21:45077557 HSF2BP -0.53 -11.27 -0.52 3.59e-25 Mean corpuscular volume; LUSC cis rs950027 0.595 rs2486288 chr15:45712339 T/C cg14582100 chr15:45693742 SPATA5L1 0.45 8.4 0.42 1.25e-15 Response to fenofibrate (adiponectin levels); LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg07677032 chr17:61819896 STRADA 0.52 8.7 0.43 1.53e-16 Prudent dietary pattern; LUSC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg07061783 chr6:25882402 NA 0.42 5.99 0.31 5.49e-9 Blood metabolite levels; LUSC cis rs1775715 0.737 rs2808090 chr10:32143208 A/C cg26784012 chr10:32216390 ARHGAP12 0.46 7.76 0.39 1.06e-13 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs412658 0.668 rs7253490 chr19:22293706 A/C cg05197062 chr11:11642011 GALNTL4 0.42 6.77 0.35 5.76e-11 Telomere length; LUSC cis rs7568458 0.709 rs11895401 chr2:85753847 C/T cg17127132 chr2:85788382 GGCX 0.41 5.93 0.31 7.66e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg22590775 chr19:49891494 CCDC155 0.55 8.02 0.4 1.81e-14 Multiple sclerosis; LUSC cis rs9398803 0.865 rs9388496 chr6:126785062 A/G cg19875578 chr6:126661172 C6orf173 0.42 6.25 0.32 1.22e-9 Male-pattern baldness; LUSC cis rs748404 0.660 rs690446 chr15:43761264 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs11792861 0.781 rs72607159 chr9:111764270 C/T cg05043794 chr9:111880884 C9orf5 -0.38 -7.96 -0.4 2.74e-14 Menarche (age at onset); LUSC cis rs10904908 1.000 rs10795465 chr10:17260525 C/T cg01003015 chr10:17271136 VIM -0.41 -5.86 -0.31 1.09e-8 Total cholesterol levels;Cholesterol, total; LUSC cis rs4722166 0.508 rs2069832 chr7:22767433 A/G cg26061582 chr7:22766209 IL6 0.5 7.23 0.37 3.28e-12 Lung cancer; LUSC cis rs757110 0.526 rs757081 chr11:17351683 C/G cg15432903 chr11:17409602 KCNJ11 -0.47 -7.74 -0.39 1.16e-13 Type 2 diabetes; LUSC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg25036284 chr2:26402008 FAM59B -0.67 -9.58 -0.46 2.32e-19 Gut microbiome composition (summer); LUSC cis rs1577917 1.000 rs36096931 chr6:86693134 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.31e-11 Response to antipsychotic treatment; LUSC cis rs7851660 0.901 rs7873389 chr9:100609230 C/T cg13688889 chr9:100608707 NA -0.62 -10.67 -0.5 4.61e-23 Strep throat; LUSC cis rs13253111 1.000 rs17411738 chr8:28060572 T/G cg26534493 chr8:28060551 NA 0.46 8.86 0.44 4.92e-17 Childhood body mass index; LUSC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg02753203 chr1:228287806 NA -0.65 -11.08 -0.52 1.69e-24 Diastolic blood pressure; LUSC trans rs6951245 0.938 rs113642700 chr7:1105654 C/T cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs34779708 0.897 rs11010131 chr10:35513316 A/C cg04310649 chr10:35416472 CREM -0.41 -6.34 -0.33 7.54e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg18301423 chr5:131593218 PDLIM4 0.37 6.1 0.32 2.94e-9 Blood metabolite levels; LUSC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg22800045 chr5:56110881 MAP3K1 0.58 7.64 0.39 2.32e-13 Type 2 diabetes; LUSC cis rs72781680 0.800 rs6718635 chr2:24066183 A/C cg08917208 chr2:24149416 ATAD2B 0.96 10.07 0.48 5.08e-21 Lymphocyte counts; LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg27170947 chr2:26402098 FAM59B -0.69 -10.53 -0.5 1.42e-22 Gut microbiome composition (summer); LUSC trans rs7824557 0.670 rs2736381 chr8:11132766 A/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.17 -0.32 1.92e-9 Retinal vascular caliber; LUSC cis rs11190604 0.725 rs9420796 chr10:102323092 G/C cg07080220 chr10:102295463 HIF1AN 0.69 8.93 0.44 2.86e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1322512 1.000 rs2758816 chr6:152968338 A/T cg27316956 chr6:152958899 SYNE1 -0.33 -5.84 -0.3 1.27e-8 Tonometry; LUSC trans rs6952808 1.000 rs6954673 chr7:1886937 C/T cg24247370 chr13:99142703 STK24 -0.34 -6.17 -0.32 1.96e-9 Bipolar disorder and schizophrenia; LUSC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg26695010 chr11:65641043 EFEMP2 -0.47 -7.08 -0.36 8.68e-12 Eosinophil percentage of white cells; LUSC cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC cis rs1448094 0.872 rs7300073 chr12:86393513 A/C cg02569458 chr12:86230093 RASSF9 0.39 6.37 0.33 6.12e-10 Major depressive disorder; LUSC trans rs208520 1.000 rs208529 chr6:66957549 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.26 -0.56 8.59e-29 Exhaled nitric oxide output; LUSC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.26 0.49 1.17e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs61990749 0.597 rs3783980 chr14:78219807 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.62 6.58 0.34 1.78e-10 Fibroblast growth factor basic levels; LUSC cis rs2677744 0.719 rs877285 chr15:91452204 A/G cg23684204 chr15:91497937 RCCD1 0.39 5.64 0.3 3.53e-8 Attention deficit hyperactivity disorder; LUSC cis rs782590 0.967 rs58003472 chr2:55797507 T/C cg18811423 chr2:55921094 PNPT1 0.82 14.19 0.61 4.35e-36 Metabolic syndrome; LUSC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg07701084 chr6:150067640 NUP43 0.53 7.99 0.4 2.25e-14 Lung cancer; LUSC cis rs1018836 0.923 rs13254212 chr8:91582355 T/C cg16814680 chr8:91681699 NA -0.75 -12.22 -0.56 1.22e-28 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs61931739 0.570 rs7315655 chr12:33912869 G/A cg06521331 chr12:34319734 NA -0.41 -6.67 -0.34 1.04e-10 Morning vs. evening chronotype; LUSC trans rs11098499 0.954 rs10518331 chr4:120323595 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.12 0.41 8.96e-15 Corneal astigmatism; LUSC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.19 0.45 4.4e-18 Age-related macular degeneration (geographic atrophy); LUSC cis rs1965732 0.917 rs9750735 chr2:3708383 A/T cg25251562 chr2:3704773 ALLC -0.39 -6.87 -0.35 3.13e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs11190604 1.000 rs10883506 chr10:102289743 C/G cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.26e-10 Palmitoleic acid (16:1n-7) levels; LUSC trans rs7657257 1.000 rs12640554 chr4:15730107 C/T cg17675199 chr6:35436792 RPL10A -0.88 -6.15 -0.32 2.26e-9 Blood protein levels; LUSC cis rs478304 0.651 rs948493 chr11:65552154 C/T cg27068330 chr11:65405492 SIPA1 -0.8 -11.33 -0.53 2.13e-25 Acne (severe); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg06665941 chr21:34602869 IFNAR2 0.44 6.72 0.35 7.72e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg14416269 chr4:6271139 WFS1 0.54 11.47 0.53 6.76e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2425143 1.000 rs11907811 chr20:34428078 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.92 -0.31 7.86e-9 Blood protein levels; LUSC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg06740227 chr12:86229804 RASSF9 0.39 6.33 0.33 7.71e-10 Major depressive disorder; LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg18404041 chr3:52824283 ITIH1 -0.57 -11.1 -0.52 1.4e-24 Bipolar disorder; LUSC cis rs10193935 0.901 rs13413617 chr2:42537546 A/G cg27598129 chr2:42591480 NA -0.57 -7.96 -0.4 2.65e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg07148914 chr20:33460835 GGT7 -0.52 -7.93 -0.4 3.28e-14 Glomerular filtration rate (creatinine); LUSC cis rs75804782 0.521 rs56387296 chr2:239426298 A/G cg18131467 chr2:239335373 ASB1 -0.67 -5.97 -0.31 6.17e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg07256732 chr16:621771 PIGQ -0.36 -6.44 -0.33 4.11e-10 Height; LUSC cis rs10986311 0.862 rs912353 chr9:127119356 A/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.36 5.69 0.3 2.83e-8 Vitiligo; LUSC cis rs13089785 1.000 rs13089785 chr3:123653909 A/C cg02012769 chr3:123398346 MYLK 0.34 6.23 0.32 1.42e-9 Intelligence (multi-trait analysis); LUSC cis rs17270561 0.609 rs1892255 chr6:25750354 G/A cg16482183 chr6:26056742 HIST1H1C 0.65 9.06 0.44 1.15e-17 Iron status biomarkers; LUSC cis rs2282300 0.739 rs1933343 chr11:30310992 T/C cg25418670 chr11:30344373 C11orf46 0.64 9.15 0.45 5.83e-18 Morning vs. evening chronotype; LUSC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.2 -0.37 4.1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2290416 0.892 rs3829012 chr8:144664656 C/T cg08017634 chr8:144659831 NAPRT1 0.7 6.19 0.32 1.79e-9 Attention deficit hyperactivity disorder; LUSC cis rs13631 0.965 rs7853589 chr9:140003844 A/G cg14289826 chr9:140003911 NA -0.38 -7.89 -0.4 4.5e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg11247378 chr22:39784982 NA -0.64 -12.52 -0.57 9.19e-30 Intelligence (multi-trait analysis); LUSC cis rs854765 0.583 rs4925129 chr17:17807186 A/G cg04398451 chr17:18023971 MYO15A -0.37 -5.82 -0.3 1.37e-8 Total body bone mineral density; LUSC cis rs9527 0.545 rs12247514 chr10:104958066 C/A cg05855489 chr10:104503620 C10orf26 0.51 7.94 0.4 3.02e-14 Arsenic metabolism; LUSC cis rs2739330 0.828 rs5760098 chr22:24248314 A/G cg01238044 chr22:24384105 GSTT1 -0.53 -7.64 -0.39 2.25e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs34421088 0.586 rs2272594 chr8:11142625 T/C cg15556689 chr8:8085844 FLJ10661 0.47 6.79 0.35 5.08e-11 Neuroticism; LUSC cis rs2200578 0.786 rs57656020 chr2:99799378 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.62 7.29 0.37 2.3e-12 IgG glycosylation; LUSC cis rs7605827 0.930 rs7605077 chr2:15546240 C/A cg19274914 chr2:15703543 NA 0.46 8.81 0.43 6.89e-17 Educational attainment (years of education); LUSC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.71 -11.81 -0.54 3.99e-27 Systemic lupus erythematosus; LUSC cis rs7241530 0.662 rs9951456 chr18:75888704 A/G cg14642773 chr18:75888474 NA 0.36 5.91 0.31 8.59e-9 Educational attainment (years of education); LUSC trans rs6952808 0.529 rs73038442 chr7:2139457 C/T cg04565464 chr8:145669602 NFKBIL2 0.37 5.99 0.31 5.49e-9 Bipolar disorder and schizophrenia; LUSC cis rs12464559 0.522 rs7424335 chr2:152593741 C/T cg01189475 chr2:152685088 ARL5A 0.67 7.53 0.38 4.8e-13 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg02018176 chr4:1364513 KIAA1530 -0.66 -11.56 -0.53 3.28e-26 Obesity-related traits; LUSC trans rs7893279 0.822 rs6415974 chr10:18715259 T/C cg01840055 chr3:141338555 NA 0.5 5.99 0.31 5.41e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg06481639 chr22:41940642 POLR3H -0.47 -5.75 -0.3 2.07e-8 Vitiligo; LUSC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08219700 chr8:58056026 NA 0.78 12.84 0.57 5.97e-31 Developmental language disorder (linguistic errors); LUSC cis rs2282300 0.739 rs7925340 chr11:30280408 A/C cg25418670 chr11:30344373 C11orf46 0.64 9.04 0.44 1.28e-17 Morning vs. evening chronotype; LUSC cis rs12410462 0.681 rs115956039 chr1:227661978 G/A cg23173402 chr1:227635558 NA 0.75 7.92 0.4 3.64e-14 Major depressive disorder; LUSC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg08280861 chr8:58055591 NA 0.54 6.3 0.33 9.15e-10 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs3922699 chr6:25734969 A/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC trans rs1941687 0.509 rs2282632 chr18:31320229 A/G cg27147174 chr7:100797783 AP1S1 -0.51 -8.07 -0.4 1.27e-14 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.87 0.4 4.94e-14 Colorectal cancer; LUSC cis rs11190604 1.000 rs10883504 chr10:102280687 G/A cg16342193 chr10:102329863 NA -0.37 -6.66 -0.34 1.15e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs478304 0.651 rs7110576 chr11:65512057 T/G cg27068330 chr11:65405492 SIPA1 -0.76 -10.92 -0.51 5.9e-24 Acne (severe); LUSC trans rs11088226 0.681 rs74779447 chr21:33929013 G/A cg09050820 chr6:167586206 TCP10L2 0.73 9.59 0.46 2.1e-19 Gastritis; LUSC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg04369109 chr6:150039330 LATS1 -0.53 -7.9 -0.4 3.96e-14 Lung cancer; LUSC cis rs6489882 0.703 rs10850096 chr12:113360786 T/C cg20102336 chr12:113376681 OAS3 -0.4 -5.71 -0.3 2.46e-8 Chronic lymphocytic leukemia; LUSC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg17971929 chr21:40555470 PSMG1 -0.62 -10.25 -0.49 1.34e-21 Cognitive function; LUSC cis rs2294693 0.947 rs6924722 chr6:41002195 C/T cg14769373 chr6:40998127 UNC5CL 0.53 7.93 0.4 3.26e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg22676075 chr6:135203613 NA 0.59 9.37 0.46 1.1e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs10788264 0.544 rs9630083 chr10:124017423 C/T cg09507567 chr10:124027408 NA 0.54 9.47 0.46 5.26e-19 Total body bone mineral density; LUSC cis rs965469 0.603 rs6051849 chr20:3404860 C/G cg25506879 chr20:3388711 C20orf194 -0.46 -6.2 -0.32 1.66e-9 IFN-related cytopenia; LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg09060608 chr5:178986726 RUFY1 -0.71 -12.58 -0.57 5.85e-30 Lung cancer; LUSC cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg19318889 chr4:1322082 MAEA 0.8 14.34 0.62 1.13e-36 Longevity; LUSC cis rs11098499 0.865 rs11722183 chr4:120280597 A/C cg24375607 chr4:120327624 NA 0.76 11.72 0.54 8.59e-27 Corneal astigmatism; LUSC cis rs10789491 1.000 rs7547522 chr1:47179918 C/G cg15501359 chr1:47185051 KIAA0494 0.81 11.42 0.53 1.05e-25 Response to hepatitis C treatment; LUSC cis rs78456975 1.000 rs11899027 chr2:1560414 G/C cg12573674 chr2:1569213 NA -0.55 -6.03 -0.31 4.38e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs34779708 0.931 rs7897457 chr10:35386040 A/G cg03585969 chr10:35415529 CREM 0.6 8.81 0.43 6.71e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg27170947 chr2:26402098 FAM59B -0.65 -9.58 -0.46 2.34e-19 Gut microbiome composition (summer); LUSC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg01368799 chr11:117014884 PAFAH1B2 0.52 6.86 0.35 3.39e-11 Blood protein levels; LUSC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg08132940 chr7:1081526 C7orf50 -0.52 -6.27 -0.32 1.11e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs977987 0.645 rs34904236 chr16:75498253 G/T cg03315344 chr16:75512273 CHST6 0.56 10.85 0.51 1.1e-23 Dupuytren's disease; LUSC trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -14.1 -0.61 9.27e-36 Height; LUSC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.41 -0.46 8.39e-19 Gut microbiome composition (summer); LUSC trans rs11098499 0.955 rs35916640 chr4:120155852 T/C cg25214090 chr10:38739885 LOC399744 0.45 6.6 0.34 1.61e-10 Corneal astigmatism; LUSC cis rs7264396 0.563 rs6058302 chr20:34290037 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.64 -0.43 2.38e-16 Total cholesterol levels; LUSC trans rs877282 1.000 rs112522746 chr10:772288 T/C cg13042288 chr15:90349979 ANPEP -0.48 -6.77 -0.35 5.86e-11 Uric acid levels; LUSC cis rs1577917 0.771 rs6454486 chr6:86433587 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.61 9.4 0.46 8.83e-19 Response to antipsychotic treatment; LUSC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg04369109 chr6:150039330 LATS1 -0.55 -7.51 -0.38 5.46e-13 Lung cancer; LUSC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg24829409 chr8:58192753 C8orf71 -0.6 -7.35 -0.37 1.59e-12 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC trans rs7829975 0.514 rs2945873 chr8:8260445 C/T cg27411982 chr8:10470053 RP1L1 0.39 6.37 0.33 6.37e-10 Mood instability; LUSC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12697442 chr11:101981167 YAP1 0.39 6.18 0.32 1.91e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg23719950 chr11:63933701 MACROD1 -0.38 -6.11 -0.32 2.8e-9 Platelet count; LUSC cis rs7131987 0.801 rs6487804 chr12:29454934 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.89 -0.35 2.71e-11 QT interval; LUSC cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg21535247 chr6:8435926 SLC35B3 0.6 9.37 0.46 1.13e-18 Motion sickness; LUSC cis rs6504340 0.793 rs12946855 chr17:46608030 G/A cg09704116 chr17:46666958 LOC404266 -0.37 -6.79 -0.35 5.27e-11 Primary tooth development (number of teeth); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg02634421 chr16:3767934 TRAP1 -0.45 -6.32 -0.33 8.33e-10 Hepatitis; LUSC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg09165964 chr15:75287851 SCAMP5 -1.06 -16.33 -0.67 1.77e-44 Blood trace element (Zn levels); LUSC cis rs12220238 1.000 rs11000916 chr10:75953909 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.12e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg12463550 chr7:65579703 CRCP -0.53 -7.72 -0.39 1.4e-13 Aortic root size; LUSC trans rs4662863 0.529 rs17049005 chr2:129766414 C/T cg05506011 chr3:118864587 C3orf30;IGSF11 0.36 6.09 0.32 3.1e-9 Gut microbiome composition (winter); LUSC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg17333051 chr19:2783644 SGTA 0.49 7.31 0.37 2.01e-12 Total cholesterol levels; LUSC cis rs7223966 1.000 rs6504169 chr17:61709145 A/G cg05941027 chr17:61774174 LIMD2 0.22 5.84 0.3 1.26e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg04545296 chr12:48745243 ZNF641 0.37 6.82 0.35 4.23e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg05707623 chr12:122985044 ZCCHC8 -0.63 -8.24 -0.41 4.04e-15 Body mass index; LUSC cis rs11677416 0.885 rs4849119 chr2:113523463 G/C cg27083787 chr2:113543245 IL1A 0.46 7.0 0.36 1.44e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs2984613 1 rs2984613 chr1:156197380 C/T cg25208724 chr1:156163844 SLC25A44 1.04 20.69 0.75 8.55e-62 Intracerebral hemorrhage;White matter hyperintensity burden; LUSC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg21433313 chr16:3507492 NAT15 0.66 11.04 0.52 2.33e-24 Tuberculosis; LUSC cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.54 -10.54 -0.5 1.29e-22 Monocyte percentage of white cells; LUSC cis rs6546550 0.901 rs6546556 chr2:70139001 A/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg18904891 chr8:8559673 CLDN23 0.6 8.24 0.41 3.84e-15 Obesity-related traits; LUSC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg16647868 chr5:131706066 SLC22A5 -0.41 -6.39 -0.33 5.65e-10 Breast cancer; LUSC cis rs8017423 0.935 rs11624890 chr14:90738165 T/A cg14092571 chr14:90743983 NA 0.36 5.77 0.3 1.78e-8 Mortality in heart failure; LUSC cis rs9300255 0.739 rs4759415 chr12:123743674 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.38 6.27 0.32 1.14e-9 Neutrophil percentage of white cells; LUSC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg06481639 chr22:41940642 POLR3H -0.53 -5.96 -0.31 6.38e-9 Vitiligo; LUSC cis rs6542838 0.646 rs2008648 chr2:99408323 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -6.04 -0.31 4.08e-9 Fear of minor pain; LUSC cis rs4474465 0.850 rs7127028 chr11:78262324 A/G cg27205649 chr11:78285834 NARS2 0.53 6.41 0.33 5.05e-10 Alzheimer's disease (survival time); LUSC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 12.1 0.55 3.39e-28 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2274273 1.000 rs7493394 chr14:55617755 A/T cg04306507 chr14:55594613 LGALS3 0.54 11.95 0.55 1.23e-27 Protein biomarker; LUSC cis rs6456156 0.586 rs12528323 chr6:167461645 A/G cg06454157 chr6:167490870 NA -0.28 -6.87 -0.35 3.1e-11 Primary biliary cholangitis; LUSC cis rs637571 0.522 rs491973 chr11:65727301 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.49 7.35 0.37 1.51e-12 Eosinophil percentage of white cells; LUSC cis rs561341 0.609 rs739800 chr17:30190083 T/A cg13647721 chr17:30228624 UTP6 -0.69 -7.5 -0.38 5.71e-13 Hip circumference adjusted for BMI; LUSC cis rs6840360 0.615 rs12503677 chr4:152610543 A/G cg22705602 chr4:152727874 NA -0.35 -7.63 -0.39 2.41e-13 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.554 rs13390883 chr2:238432619 A/T cg16989719 chr2:238392110 NA -0.41 -5.77 -0.3 1.85e-8 Prostate cancer; LUSC cis rs763121 0.815 rs12168758 chr22:38997269 C/G cg06544989 chr22:39130855 UNC84B 0.32 5.81 0.3 1.48e-8 Menopause (age at onset); LUSC cis rs4595586 0.545 rs11609541 chr12:39378331 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg13902645 chr11:5959945 NA -0.64 -8.7 -0.43 1.55e-16 DNA methylation (variation); LUSC cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg06271696 chr7:157225062 NA -0.41 -8.01 -0.4 1.91e-14 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg08999081 chr20:33150536 PIGU 0.44 8.04 0.4 1.6e-14 Coronary artery disease; LUSC cis rs6754311 0.731 rs2164210 chr2:136580287 T/C cg25344623 chr2:136566232 LCT 0.38 5.73 0.3 2.27e-8 Mosquito bite size; LUSC cis rs7582720 1.000 rs72936326 chr2:204054141 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.29 0.41 2.71e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6977660 1.000 rs12666159 chr7:19804199 T/C cg07541023 chr7:19748670 TWISTNB 0.54 6.18 0.32 1.83e-9 Thyroid stimulating hormone; LUSC cis rs9326248 0.581 rs7120515 chr11:116991926 A/G cg20608306 chr11:116969690 SIK3 0.36 6.74 0.35 7.05e-11 Blood protein levels; LUSC cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.45 -0.42 9.15e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg18306943 chr3:40428807 ENTPD3 0.38 5.73 0.3 2.23e-8 Renal cell carcinoma; LUSC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.6 7.65 0.39 2.12e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs6459788 0.692 rs10807645 chr7:157258979 T/C cg03453431 chr7:157225567 NA 0.57 9.12 0.45 7.31e-18 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18099408 chr3:52552593 STAB1 -0.4 -7.02 -0.36 1.23e-11 Bipolar disorder; LUSC cis rs2898681 0.528 rs73814883 chr4:53728054 G/C cg00791764 chr4:53727839 RASL11B 0.58 7.35 0.37 1.54e-12 Optic nerve measurement (cup area); LUSC cis rs6723226 0.764 rs176403 chr2:32637864 C/A cg02381751 chr2:32503542 YIPF4 -0.62 -9.36 -0.46 1.18e-18 Intelligence (multi-trait analysis); LUSC cis rs2742417 0.967 rs9877499 chr3:45734404 G/A cg09608765 chr3:45636137 LIMD1 -0.37 -7.23 -0.37 3.35e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg06784218 chr1:46089804 CCDC17 0.57 11.63 0.54 1.79e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2742417 0.967 rs1534875 chr3:45741043 T/G cg09608765 chr3:45636137 LIMD1 -0.37 -7.43 -0.38 8.99e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg08677398 chr8:58056175 NA 0.54 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg04944784 chr2:26401820 FAM59B -0.75 -11.04 -0.52 2.23e-24 Gut microbiome composition (summer); LUSC cis rs11098499 0.866 rs12501602 chr4:120287935 A/T cg09307838 chr4:120376055 NA 0.69 10.21 0.49 1.77e-21 Corneal astigmatism; LUSC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.61 0.5 7.35e-23 Monocyte percentage of white cells; LUSC cis rs9457247 0.624 rs17524252 chr6:167466978 T/G cg07741184 chr6:167504864 NA 0.49 8.61 0.43 3.03e-16 Crohn's disease; LUSC cis rs17604090 0.550 rs111649163 chr7:29689176 C/T cg19413766 chr7:29689036 LOC646762 -0.63 -7.69 -0.39 1.62e-13 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg19812747 chr11:111475976 SIK2 -0.55 -7.91 -0.4 3.85e-14 Primary sclerosing cholangitis; LUSC cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg06784218 chr1:46089804 CCDC17 -0.46 -8.86 -0.44 4.7e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2742234 0.578 rs2742241 chr10:43625223 G/A cg02780029 chr10:43622663 RET -0.35 -5.97 -0.31 5.99e-9 Hirschsprung disease; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg06873352 chr17:61820015 STRADA 0.73 12.98 0.58 1.75e-31 Prudent dietary pattern; LUSC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg13939156 chr17:80058883 NA -0.33 -6.56 -0.34 2.02e-10 Life satisfaction; LUSC cis rs12704876 0.509 rs1608741 chr7:96354206 G/A cg03808172 chr7:96339361 SHFM1 0.52 8.04 0.4 1.52e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg27211696 chr2:191398769 TMEM194B 0.6 11.64 0.54 1.6e-26 Pulse pressure; LUSC cis rs7829975 0.557 rs7816427 chr8:8545884 T/C cg06636001 chr8:8085503 FLJ10661 -0.48 -6.84 -0.35 3.76e-11 Mood instability; LUSC trans rs61931739 0.500 rs10844862 chr12:34531965 A/T cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs7804356 1.000 rs3801803 chr7:26901740 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.1 -0.32 2.9e-9 Type 1 diabetes; LUSC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg11632617 chr15:75315747 PPCDC -0.5 -6.58 -0.34 1.86e-10 Blood trace element (Zn levels); LUSC cis rs55728055 0.661 rs73162106 chr22:32034875 A/G cg01338084 chr22:32026380 PISD 0.82 6.18 0.32 1.83e-9 Age-related hearing impairment; LUSC cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.63 0.5 6.13e-23 Bladder cancer; LUSC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg11062466 chr8:58055876 NA 0.5 6.45 0.33 3.85e-10 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg16325326 chr1:53192061 ZYG11B -0.9 -16.97 -0.68 4.92e-47 Monocyte count; LUSC cis rs739401 1.000 rs739401 chr11:3036324 C/T cg05729581 chr11:3078854 CARS 0.41 6.03 0.31 4.4e-9 Longevity; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.51 8.06 0.4 1.37e-14 Prudent dietary pattern; LUSC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg09877947 chr5:131593287 PDLIM4 -0.46 -7.64 -0.39 2.37e-13 Breast cancer; LUSC cis rs6089584 0.893 rs2281735 chr20:60582540 T/A cg06108461 chr20:60628389 TAF4 -0.97 -16.59 -0.67 1.62e-45 Body mass index; LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.95 -12.54 -0.57 8.28e-30 Platelet count; LUSC cis rs2274273 0.648 rs58553156 chr14:55582694 T/A cg04306507 chr14:55594613 LGALS3 0.48 9.74 0.47 6.8e-20 Protein biomarker; LUSC cis rs7246967 0.604 rs58536761 chr19:22880331 G/C cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.97 0.48 1.11e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs35000415 0.938 rs35234849 chr7:128648953 T/C cg19972273 chr7:128594194 NA 0.68 6.79 0.35 5.04e-11 Systemic lupus erythematosus; LUSC cis rs4595586 0.545 rs6580889 chr12:39369742 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.79 0.3 1.58e-8 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11461694 chr4:103266404 SLC39A8 0.4 6.05 0.31 3.88e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg14993813 chr1:46806288 NSUN4 -0.53 -7.41 -0.38 1.06e-12 Menopause (age at onset); LUSC cis rs1003719 0.788 rs2006941 chr21:38467616 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs62458065 0.640 rs79619897 chr7:32514819 C/T cg20159608 chr7:32802032 NA -0.74 -9.31 -0.45 1.7e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7833986 0.501 rs2976012 chr8:56974343 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.46 0.56 1.61e-29 Height; LUSC cis rs79387448 0.745 rs9677607 chr2:103149520 A/T cg09003973 chr2:102972529 NA 0.87 8.58 0.42 3.72e-16 Gut microbiota (bacterial taxa); LUSC cis rs590121 0.876 rs585821 chr11:75282882 C/T cg26104986 chr11:75275303 SERPINH1 -0.28 -5.87 -0.31 1.05e-8 Coronary artery disease; LUSC cis rs4969178 0.965 rs11077362 chr17:76397219 A/T cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs4363385 0.818 rs409986 chr1:153014741 A/C cg25856811 chr1:152973957 SPRR3 0.34 5.82 0.3 1.37e-8 Inflammatory skin disease; LUSC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg15017067 chr4:17643749 FAM184B 0.34 5.66 0.3 3.27e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7927592 0.913 rs3740631 chr11:68341722 T/G cg16797656 chr11:68205561 LRP5 0.38 6.2 0.32 1.62e-9 Total body bone mineral density; LUSC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg09877947 chr5:131593287 PDLIM4 0.38 6.13 0.32 2.47e-9 Blood metabolite levels; LUSC cis rs7089973 0.668 rs10885622 chr10:116643844 C/T cg23260525 chr10:116636907 FAM160B1 0.42 8.27 0.41 3.12e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.45 -0.33 3.84e-10 Total body bone mineral density; LUSC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg25566285 chr7:158114605 PTPRN2 -0.33 -6.21 -0.32 1.55e-9 Calcium levels; LUSC cis rs6714710 0.603 rs6757357 chr2:98491750 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.18e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg05025164 chr4:1340916 KIAA1530 0.65 9.98 0.48 1.08e-20 Longevity; LUSC cis rs8114671 0.647 rs6060268 chr20:33734293 T/C cg24642439 chr20:33292090 TP53INP2 0.4 5.74 0.3 2.08e-8 Height; LUSC cis rs7584330 0.737 rs1497127 chr2:238369282 A/G cg16989719 chr2:238392110 NA -0.38 -6.69 -0.34 9.7e-11 Prostate cancer; LUSC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC trans rs1600249 0.562 rs17153419 chr8:11394233 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.3 -0.33 9.49e-10 Rheumatoid arthritis; LUSC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 7.89e-25 Mean corpuscular volume; LUSC cis rs61990749 0.500 rs8011337 chr14:78272626 T/G cg02301378 chr14:78227641 SNW1;C14orf178 0.58 6.04 0.31 4e-9 Fibroblast growth factor basic levels; LUSC cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.57 0.34 1.9e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2219968 0.717 rs4739188 chr8:78912778 G/T cg00738934 chr8:78996279 NA -0.38 -7.02 -0.36 1.26e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1670533 0.932 rs13140341 chr4:1054235 T/C cg02018176 chr4:1364513 KIAA1530 0.43 5.93 0.31 7.5e-9 Recombination rate (females); LUSC cis rs7474896 0.515 rs662928 chr10:38316216 G/T cg25427524 chr10:38739819 LOC399744 0.43 5.69 0.3 2.75e-8 Obesity (extreme); LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg07677032 chr17:61819896 STRADA 0.55 9.2 0.45 4.08e-18 Prudent dietary pattern; LUSC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg01879757 chr17:41196368 BRCA1 -0.47 -7.58 -0.38 3.45e-13 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22755008 chr11:1715418 HCCA2 -0.42 -6.3 -0.33 9.13e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.82 12.33 0.56 4.85e-29 Chronic sinus infection; LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg01171360 chr6:293285 DUSP22 -0.68 -10.94 -0.51 5.25e-24 Menopause (age at onset); LUSC cis rs6912958 0.712 rs2787927 chr6:88412786 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.71 -0.43 1.39e-16 Monocyte percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15709784 chr12:64845926 TBK1 -0.44 -6.79 -0.35 5.12e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1448094 0.842 rs12809288 chr12:86455427 C/T cg02569458 chr12:86230093 RASSF9 -0.37 -5.89 -0.31 9.65e-9 Major depressive disorder; LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.1 0.52 1.39e-24 Alzheimer's disease; LUSC cis rs9807989 0.839 rs10192157 chr2:102968356 C/T cg09003973 chr2:102972529 NA 0.44 6.01 0.31 4.83e-9 Asthma; LUSC trans rs3733585 0.673 rs7377578 chr4:9952775 T/C cg26043149 chr18:55253948 FECH -0.45 -6.86 -0.35 3.42e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg17971929 chr21:40555470 PSMG1 -0.51 -7.57 -0.38 3.69e-13 Menarche (age at onset); LUSC cis rs16958440 0.581 rs11873880 chr18:44692465 T/C cg17192377 chr18:44677553 HDHD2 0.52 6.12 0.32 2.6e-9 Sitting height ratio; LUSC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg26818010 chr10:134567672 INPP5A -0.86 -11.36 -0.53 1.64e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -8.73 -0.43 1.21e-16 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs853679 0.567 rs1005126 chr6:28367623 C/G cg01620082 chr3:125678407 NA -0.44 -6.53 -0.34 2.47e-10 Depression; LUSC cis rs11252926 0.625 rs7903876 chr10:482678 T/C cg03684893 chr10:554711 DIP2C 0.38 6.94 0.36 2.03e-11 Psychosis in Alzheimer's disease; LUSC cis rs7481584 0.624 rs428726 chr11:3046201 G/A cg08508325 chr11:3079039 CARS 0.36 8.22 0.41 4.48e-15 Calcium levels; LUSC cis rs4786125 0.920 rs7194057 chr16:6895960 T/C cg03623568 chr16:6915990 A2BP1 -0.46 -7.63 -0.39 2.44e-13 Heart rate variability traits (SDNN); LUSC cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.46 6.16 0.32 2.04e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg11060661 chr22:24314208 DDT;DDTL 0.48 7.87 0.4 4.96e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1973993 0.745 rs56119386 chr1:96962215 C/T cg10631902 chr5:14652156 NA -0.41 -6.03 -0.31 4.46e-9 Weight; LUSC cis rs6121246 0.522 rs6088736 chr20:30195166 C/G cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs1113500 0.787 rs12047429 chr1:108633239 C/T cg06207961 chr1:108661230 NA 0.3 5.71 0.3 2.5e-8 Growth-regulated protein alpha levels; LUSC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.88e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs67311347 0.605 rs1880762 chr3:40283215 A/G cg13683864 chr3:40499215 RPL14 -0.89 -13.23 -0.59 2.07e-32 Renal cell carcinoma; LUSC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg12257692 chr3:49977190 RBM6 0.24 6.61 0.34 1.49e-10 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.2 -0.37 4.1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs11098499 0.863 rs13134665 chr4:120426430 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.54 0.34 2.24e-10 Corneal astigmatism; LUSC cis rs11711311 0.868 rs13091621 chr3:113481977 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.92 0.35 2.34e-11 IgG glycosylation; LUSC cis rs6424115 1.000 rs12121387 chr1:24166536 T/G cg10978503 chr1:24200527 CNR2 -0.5 -11.76 -0.54 5.88e-27 Immature fraction of reticulocytes; LUSC cis rs10791323 0.601 rs7946883 chr11:133733864 T/C cg00579200 chr11:133705235 NA -0.41 -6.19 -0.32 1.74e-9 Childhood ear infection; LUSC cis rs208520 0.661 rs1776361 chr6:66822270 G/A cg07460842 chr6:66804631 NA -1.15 -18.35 -0.71 1.67e-52 Exhaled nitric oxide output; LUSC cis rs9929218 1.000 rs12921546 chr16:68780069 G/A cg02972257 chr16:68554789 NA 0.42 5.73 0.3 2.3e-8 Colorectal cancer; LUSC cis rs4356932 1.000 rs4356932 chr4:76955194 T/C cg00809888 chr4:76862425 NAAA 0.35 5.81 0.3 1.45e-8 Blood protein levels; LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg22166914 chr1:53195759 ZYG11B -0.48 -7.62 -0.39 2.57e-13 Monocyte count; LUSC cis rs4654899 0.865 rs61779065 chr1:21356474 A/T cg01072550 chr1:21505969 NA -0.54 -7.93 -0.4 3.4e-14 Superior frontal gyrus grey matter volume; LUSC trans rs853679 1.000 rs853679 chr6:28296863 C/A cg01620082 chr3:125678407 NA -0.57 -6.5 -0.34 2.91e-10 Depression; LUSC cis rs7100689 0.646 rs10788586 chr10:82117435 A/G cg01528321 chr10:82214614 TSPAN14 0.86 13.02 0.58 1.23e-31 Post bronchodilator FEV1; LUSC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg05890377 chr2:74357713 NA 0.72 13.83 0.6 1.03e-34 Gestational age at birth (maternal effect); LUSC cis rs6696846 0.765 rs61822619 chr1:205090885 C/G cg03948781 chr1:205179583 DSTYK 0.33 6.32 0.33 8.23e-10 Red blood cell count; LUSC cis rs9300255 0.510 rs1790133 chr12:123698518 T/G cg00376283 chr12:123451042 ABCB9 0.64 8.07 0.4 1.24e-14 Neutrophil percentage of white cells; LUSC cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg13256891 chr4:100009986 ADH5 0.48 7.11 0.36 7.05e-12 Alcohol dependence; LUSC cis rs6138458 1.000 rs227658 chr20:24932028 A/G cg26195577 chr20:24973756 C20orf3 1.12 18.21 0.71 6.24e-52 Blood protein levels; LUSC cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg08999081 chr20:33150536 PIGU 0.52 10.24 0.49 1.44e-21 Glomerular filtration rate (creatinine); LUSC trans rs3857536 0.611 rs7748258 chr6:66932840 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.44e-9 Blood trace element (Cu levels); LUSC cis rs644799 0.562 rs669973 chr11:95571839 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.6 9.08 0.45 9.34e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.3e-11 Monocyte count; LUSC cis rs9815354 1.000 rs17063649 chr3:41863406 C/T cg03022575 chr3:42003672 ULK4 0.58 6.54 0.34 2.3e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg01238044 chr22:24384105 GSTT1 0.58 9.52 0.46 3.65e-19 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11018904 0.906 rs55685917 chr11:89964365 T/C cg26834418 chr11:89957033 CHORDC1 -0.5 -6.34 -0.33 7.54e-10 Intelligence (multi-trait analysis); LUSC trans rs1997103 0.765 rs55686950 chr7:55396552 A/C cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs67311347 0.713 rs9861194 chr3:40309225 C/T cg13683864 chr3:40499215 RPL14 -0.91 -15.79 -0.65 2.46e-42 Renal cell carcinoma; LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg02951883 chr7:2050386 MAD1L1 -0.35 -6.09 -0.32 3.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs9788721 0.836 rs17484524 chr15:78772676 A/G cg18825076 chr15:78729989 IREB2 -0.63 -10.25 -0.49 1.32e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg04800585 chr6:26043546 HIST1H2BB 0.39 5.83 0.3 1.31e-8 Intelligence (multi-trait analysis); LUSC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.1 0.32 2.97e-9 Mean platelet volume; LUSC trans rs8072100 0.846 rs7214799 chr17:45702099 C/T cg03886242 chr7:26192032 NFE2L3 0.38 6.16 0.32 2.1e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1163251 0.869 rs487884 chr1:120217330 C/T cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC cis rs4268898 0.722 rs10445893 chr2:24407128 A/G cg06627628 chr2:24431161 ITSN2 0.55 7.75 0.39 1.13e-13 Asthma; LUSC cis rs983392 0.679 rs10736701 chr11:60031476 C/T cg02771260 chr11:59836817 MS4A3 0.37 6.11 0.32 2.83e-9 Alzheimer's disease (late onset); LUSC trans rs1600249 0.562 rs17153419 chr8:11394233 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -7.2 -0.37 4e-12 Rheumatoid arthritis; LUSC cis rs7605827 0.897 rs13017859 chr2:15537641 T/C cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.59 0.5 8.56e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04428535 chr19:50432391 NUP62;IL4I1;ATF5 -0.46 -6.3 -0.33 9.66e-10 Bipolar disorder and schizophrenia; LUSC cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg12365402 chr11:9010492 NRIP3 0.37 6.76 0.35 5.99e-11 Hemoglobin concentration; LUSC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg09699651 chr6:150184138 LRP11 0.44 6.98 0.36 1.64e-11 Testicular germ cell tumor; LUSC cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.48 0.42 7.32e-16 Motion sickness; LUSC cis rs1979679 0.608 rs1581073 chr12:28724039 A/G cg13890972 chr12:28721907 NA -0.42 -6.07 -0.32 3.45e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg01411255 chr17:61851458 DDX42;CCDC47 -0.7 -11.82 -0.54 3.53e-27 Prudent dietary pattern; LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg18404041 chr3:52824283 ITIH1 -0.6 -11.67 -0.54 1.23e-26 Bipolar disorder; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.67 -0.39 1.88e-13 Lymphocyte counts; LUSC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg23093090 chr10:104574429 C10orf26 -0.37 -7.06 -0.36 9.42e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg20476274 chr7:133979776 SLC35B4 0.87 17.01 0.68 3.4e-47 Mean platelet volume; LUSC cis rs9399135 0.967 rs4896121 chr6:135293645 T/C cg22676075 chr6:135203613 NA 0.47 7.4 0.38 1.13e-12 Red blood cell count; LUSC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg24642844 chr7:1081250 C7orf50 -0.45 -7.25 -0.37 2.97e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg08330031 chr10:104623503 C10orf32 0.31 5.65 0.3 3.36e-8 Arsenic metabolism; LUSC trans rs10435719 0.899 rs9329251 chr8:11793606 G/A cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.64e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1692580 0.840 rs696094 chr1:2169215 G/A cg24578937 chr1:2090814 PRKCZ 0.37 7.65 0.39 2.21e-13 Coronary artery disease; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.56 -8.72 -0.43 1.33e-16 Lymphocyte counts; LUSC cis rs6690583 1.000 rs10443172 chr1:85485768 T/C cg11262906 chr1:85462892 MCOLN2 -0.72 -8.8 -0.43 7.73e-17 Serum sulfate level; LUSC cis rs10465746 0.905 rs11163875 chr1:84429605 T/G cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.01e-9 Obesity-related traits; LUSC cis rs3916 1.000 rs3916 chr12:121177272 G/C cg02419362 chr12:121203948 SPPL3 0.36 5.76 0.3 1.87e-8 Urinary metabolites (H-NMR features); LUSC cis rs61142792 0.590 rs747861 chr5:177037397 C/G cg03428951 chr5:177434336 FAM153C 0.66 5.68 0.3 2.88e-8 Alzheimer disease and age of onset; LUSC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg02772935 chr3:125709198 NA -0.48 -5.82 -0.3 1.36e-8 Blood pressure (smoking interaction); LUSC cis rs17401966 0.522 rs10864450 chr1:10333959 G/T cg19773385 chr1:10388646 KIF1B -0.35 -6.17 -0.32 2.01e-9 Hepatocellular carcinoma; LUSC cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.04 0.55 5.79e-28 Motion sickness; LUSC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg19717773 chr7:2847554 GNA12 0.37 6.06 0.31 3.62e-9 Height; LUSC cis rs4654899 0.865 rs10916910 chr1:21283192 G/T cg02927042 chr1:21476669 EIF4G3 -0.41 -6.44 -0.33 4.17e-10 Superior frontal gyrus grey matter volume; LUSC cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg07274523 chr3:49395745 GPX1 0.68 10.47 0.5 2.21e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC trans rs9929218 1.000 rs17772363 chr16:68788909 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -12.26 -0.56 8.92e-29 Colorectal cancer; LUSC cis rs2860975 0.936 rs7904000 chr10:96767858 A/T cg09036531 chr10:96991505 NA -0.4 -5.66 -0.3 3.31e-8 Immune response to smallpox vaccine (IL-6); LUSC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg09655341 chr17:79618100 PDE6G -0.3 -7.07 -0.36 9.28e-12 Eye color traits; LUSC cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg22508957 chr16:3507546 NAT15 0.44 6.26 0.32 1.16e-9 Body mass index (adult); LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.15 -0.49 2.83e-21 Alzheimer's disease; LUSC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.2e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12618769 0.572 rs4851141 chr2:99112966 A/C cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC trans rs7980799 0.649 rs10772088 chr12:33663849 A/T cg26384229 chr12:38710491 ALG10B -0.57 -8.22 -0.41 4.44e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg03233332 chr7:66118400 NA -0.43 -6.15 -0.32 2.22e-9 Aortic root size; LUSC cis rs10779751 1.000 rs2300092 chr1:11266464 T/C cg08854313 chr1:11322531 MTOR 0.92 16.42 0.67 7.99e-45 Body mass index; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg26309655 chr1:150459725 TARS2 0.49 6.07 0.32 3.54e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs11051970 0.877 rs2728671 chr12:32589715 T/A cg02745156 chr12:32552066 NA 0.43 7.29 0.37 2.29e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs11190604 1.000 rs4919472 chr10:102315864 T/A cg07080220 chr10:102295463 HIF1AN 0.68 8.7 0.43 1.54e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7428496 0.528 rs11923612 chr3:142290490 T/C cg16271453 chr3:142027066 XRN1 -0.49 -8.44 -0.42 9.99e-16 Mean corpuscular hemoglobin; LUSC cis rs11190604 1.000 rs10883507 chr10:102291275 C/T cg07080220 chr10:102295463 HIF1AN 0.7 9.4 0.46 8.73e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg01657329 chr11:68192670 LRP5 -0.45 -7.18 -0.37 4.58e-12 Total body bone mineral density; LUSC cis rs4409675 0.576 rs11247706 chr1:28213983 G/C cg23691781 chr1:28212827 C1orf38 0.32 7.68 0.39 1.8e-13 Corneal astigmatism; LUSC cis rs2274273 0.870 rs8023197 chr14:55767395 G/T cg04306507 chr14:55594613 LGALS3 0.56 13.11 0.58 5.6199999999999995e-32 Protein biomarker; LUSC cis rs4629180 0.586 rs10206804 chr2:102132431 C/T cg01388757 chr2:102091195 RFX8 0.37 6.4 0.33 5.12e-10 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7666738 0.546 rs6827131 chr4:98744810 C/G cg03676636 chr4:99064102 C4orf37 0.3 5.96 0.31 6.52e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9469578 0.792 rs73743331 chr6:33714036 G/T cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs2404602 0.530 rs12915184 chr15:76965922 G/A cg23625390 chr15:77176239 SCAPER -0.62 -8.91 -0.44 3.33e-17 Blood metabolite levels; LUSC cis rs7927771 0.524 rs7107922 chr11:47669289 C/A cg18512352 chr11:47633146 NA 0.28 5.76 0.3 1.89e-8 Subjective well-being; LUSC cis rs2839186 0.967 rs9637172 chr21:47685787 T/C cg11766577 chr21:47581405 C21orf56 -0.46 -6.85 -0.35 3.5e-11 Testicular germ cell tumor; LUSC cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg23992470 chr4:843637 GAK 0.69 7.0 0.36 1.42e-11 Intelligence (multi-trait analysis); LUSC cis rs2130392 0.886 rs2077205 chr4:185637418 C/T cg04058563 chr4:185651563 MLF1IP 0.41 6.63 0.34 1.36e-10 Kawasaki disease; LUSC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg22907277 chr7:1156413 C7orf50 0.39 5.82 0.3 1.39e-8 Longevity;Endometriosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05264411 chr1:171455311 BAT2L2 0.48 6.64 0.34 1.27e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1448094 0.706 rs10863149 chr12:86425498 A/T cg00310523 chr12:86230176 RASSF9 0.38 6.91 0.35 2.45e-11 Major depressive disorder; LUSC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg20203395 chr5:56204925 C5orf35 -0.46 -6.88 -0.35 3.03e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs6750047 0.638 rs336031 chr2:38265130 C/A cg07380506 chr2:38303506 CYP1B1 -0.43 -5.84 -0.3 1.23e-8 Cutaneous malignant melanoma;Melanoma; LUSC cis rs2455601 0.507 rs7948452 chr11:8877704 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -8.3 -0.41 2.67e-15 Schizophrenia; LUSC cis rs2932538 0.922 rs112363416 chr1:113107543 T/C cg22162597 chr1:113214053 CAPZA1 0.71 10.07 0.48 5.38e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs2839186 0.739 rs7282763 chr21:47696800 C/T cg05896524 chr21:47604654 C21orf56 0.42 6.2 0.32 1.69e-9 Testicular germ cell tumor; LUSC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg19318889 chr4:1322082 MAEA 0.46 7.48 0.38 6.61e-13 Obesity-related traits; LUSC trans rs7746199 0.673 rs72845046 chr6:27575268 T/A cg01620082 chr3:125678407 NA -0.77 -7.12 -0.36 6.8e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs6674970 0.933 rs12134957 chr1:151045419 A/G cg03258749 chr1:151040405 MLLT11 -0.44 -6.7 -0.34 8.69e-11 Childhood ear infection; LUSC cis rs709400 0.663 rs7158822 chr14:103887868 C/T cg24130564 chr14:104152367 KLC1 -0.42 -6.03 -0.31 4.31e-9 Body mass index; LUSC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.07 -0.36 9.27e-12 Lung cancer; LUSC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg03354898 chr7:1950403 MAD1L1 -0.42 -8.43 -0.42 1.05e-15 Bipolar disorder and schizophrenia; LUSC cis rs17826219 0.706 rs73271850 chr17:29142140 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Body mass index; LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg25072359 chr17:41440525 NA 0.65 9.34 0.46 1.37e-18 Menopause (age at onset); LUSC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.86 0.39 5.51e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg15549821 chr19:49342101 PLEKHA4 -0.52 -6.09 -0.32 3.13e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg08470875 chr2:26401718 FAM59B -0.65 -8.59 -0.43 3.38e-16 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg08219700 chr8:58056026 NA 0.66 8.37 0.42 1.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs10752881 0.935 rs12082051 chr1:183051614 C/T ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Colorectal cancer; LUSC cis rs7267979 1.000 rs2257991 chr20:25270339 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.39 -0.74 1.35e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11864453 0.647 rs9941346 chr16:72135707 C/G cg16558253 chr16:72132732 DHX38 -0.38 -6.07 -0.32 3.45e-9 Fibrinogen levels; LUSC trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21659725 chr3:3221576 CRBN -0.59 -8.27 -0.41 3.21e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.8 9.4 0.46 8.76e-19 Mean platelet volume; LUSC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.88 0.58 4.26e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg07217954 chr7:1067459 C7orf50 0.54 5.7 0.3 2.62e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs8072100 0.811 rs9889709 chr17:45445229 C/T cg04995722 chr7:26192034 NFE2L3 -0.4 -6.36 -0.33 6.8e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9399135 0.967 rs13199205 chr6:135286505 T/C cg22676075 chr6:135203613 NA 0.49 7.66 0.39 2.02e-13 Red blood cell count; LUSC trans rs61931739 0.963 rs3912355 chr12:34079616 A/G cg13010199 chr12:38710504 ALG10B 0.41 6.26 0.32 1.17e-9 Morning vs. evening chronotype; LUSC cis rs77741769 0.529 rs1467283 chr12:121210220 G/C cg02419362 chr12:121203948 SPPL3 0.46 8.46 0.42 8.71e-16 Mean corpuscular volume; LUSC cis rs10504229 0.516 rs1866994 chr8:57990092 A/C cg21724239 chr8:58056113 NA 0.43 5.66 0.3 3.18e-8 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg18512352 chr11:47633146 NA 0.48 9.94 0.48 1.45e-20 Subjective well-being; LUSC cis rs11690935 0.632 rs1607254 chr2:172626552 A/G cg13550731 chr2:172543902 DYNC1I2 0.57 8.96 0.44 2.37e-17 Schizophrenia; LUSC cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg08045932 chr20:61659980 NA 0.57 9.68 0.47 1.09e-19 Prostate cancer (SNP x SNP interaction); LUSC cis rs1957429 0.808 rs1957436 chr14:65348207 T/G cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC cis rs2797160 1.000 rs13328298 chr6:126016580 G/A cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.96e-16 Endometrial cancer; LUSC cis rs308447 0.516 rs13142203 chr4:123679002 T/C cg10495464 chr4:123653540 BBS12;LOC729338 0.84 11.13 0.52 1.08e-24 Perceived unattractiveness to mosquitoes; LUSC cis rs7560272 0.538 rs7370393 chr2:73925636 A/C cg20560298 chr2:73613845 ALMS1 0.4 6.1 0.32 2.92e-9 Schizophrenia; LUSC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg05110241 chr16:68378359 PRMT7 -0.55 -6.45 -0.33 4.01e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg18479299 chr3:125709523 NA -0.49 -6.0 -0.31 5.05e-9 Blood pressure (smoking interaction); LUSC cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg06784218 chr1:46089804 CCDC17 0.48 9.2 0.45 3.91e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs6582630 0.555 rs34884627 chr12:38443831 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.06e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg26513180 chr16:89883248 FANCA 0.74 11.33 0.53 2.06e-25 Vitiligo; LUSC cis rs35771425 0.518 rs1055565 chr1:211605697 G/A cg25617285 chr1:211431773 RCOR3 -0.36 -5.72 -0.3 2.42e-8 Educational attainment (years of education); LUSC cis rs1904096 0.506 rs28701470 chr4:95167088 A/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -8.08 -0.4 1.18e-14 Type 2 diabetes; LUSC cis rs677665 0.918 rs11590326 chr1:9339205 A/G cg25755851 chr1:9335794 NA -0.61 -10.1 -0.48 4.15e-21 Eosinophil percentage of white cells; LUSC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg09877947 chr5:131593287 PDLIM4 -0.38 -6.15 -0.32 2.27e-9 Breast cancer;Mosquito bite size; LUSC cis rs78366141 0.649 rs76401410 chr4:89694624 A/G cg01026744 chr4:89619053 NAP1L5;HERC3 1.02 7.32 0.37 1.85e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg16797656 chr11:68205561 LRP5 0.36 6.04 0.31 4.2e-9 Total body bone mineral density; LUSC cis rs868036 0.634 rs8028313 chr15:68043057 C/G cg08079166 chr15:68083412 MAP2K5 0.4 7.13 0.36 6.39e-12 Restless legs syndrome; LUSC cis rs950027 0.596 rs2467853 chr15:45698793 T/G cg26924012 chr15:45694286 SPATA5L1 0.76 11.7 0.54 9.97e-27 Response to fenofibrate (adiponectin levels); LUSC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg05368731 chr17:41323189 NBR1 0.93 15.63 0.65 1.01e-41 Menopause (age at onset); LUSC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg27539214 chr16:67997921 SLC12A4 -0.58 -7.71 -0.39 1.42e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs3806843 0.576 rs246034 chr5:140332064 A/C cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.62 9.4 0.46 9.01e-19 Height; LUSC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs7312933 0.558 rs1796388 chr12:42785987 G/C cg01256987 chr12:42539512 GXYLT1 0.36 6.69 0.34 9.16e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs6582630 0.548 rs8189608 chr12:38327775 T/G cg13010199 chr12:38710504 ALG10B -0.44 -6.55 -0.34 2.23e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs9399135 0.967 rs6910530 chr6:135332770 C/T cg24558204 chr6:135376177 HBS1L 0.61 9.55 0.46 2.86e-19 Red blood cell count; LUSC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg15556689 chr8:8085844 FLJ10661 -0.55 -8.57 -0.42 3.84e-16 Neuroticism; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg17243540 chr1:12018611 PLOD1 -0.73 -6.51 -0.34 2.73e-10 Body mass index; LUSC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg02380750 chr20:61661411 NA 0.34 5.97 0.31 6.11e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs62103177 0.810 rs62103189 chr18:77627815 G/A cg05926928 chr17:57297772 GDPD1 1.49 16.86 0.68 1.38e-46 Opioid sensitivity; LUSC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg20933634 chr6:27740509 NA -0.42 -6.01 -0.31 4.94e-9 Parkinson's disease; LUSC cis rs7903847 0.620 rs9787454 chr10:99155561 A/T cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs17685 0.753 rs10085567 chr7:75734206 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.53 -8.04 -0.4 1.62e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2739330 0.828 rs5760102 chr22:24248761 T/C cg00024416 chr22:24240387 NA -0.33 -5.67 -0.3 3.09e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs16857609 0.600 rs10932715 chr2:218259783 A/G cg15335768 chr2:218268053 DIRC3 -0.32 -5.95 -0.31 6.85e-9 Breast cancer;Breast cancer (estrogen-receptor negative); LUSC cis rs2742234 0.541 rs1317214 chr10:43733531 C/G cg15436174 chr10:43711423 RASGEF1A 0.43 7.05 0.36 1.03e-11 Hirschsprung disease; LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.9 0.48 2.03e-20 Bipolar disorder; LUSC cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14240646 chr10:27532245 ACBD5 -0.65 -7.75 -0.39 1.15e-13 Breast cancer; LUSC cis rs6733011 0.578 rs12712039 chr2:99497980 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.44 -6.04 -0.31 4.14e-9 Bipolar disorder; LUSC cis rs9807989 0.839 rs11695627 chr2:102970105 A/G cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs9914988 1.000 rs6803 chr17:27187789 C/T cg09479241 chr17:27052676 TLCD1 -0.43 -5.73 -0.3 2.23e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs10432489 0.541 rs6724902 chr2:181739323 A/T cg04744134 chr19:8408128 KANK3 -0.77 -6.18 -0.32 1.87e-9 QT interval; LUSC cis rs10761482 0.861 rs2393625 chr10:62119206 A/G cg18175470 chr10:62150864 ANK3 0.5 7.16 0.36 5.17e-12 Schizophrenia; LUSC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg04398451 chr17:18023971 MYO15A 0.5 8.03 0.4 1.73e-14 Strep throat; LUSC cis rs208520 0.690 rs1776365 chr6:66834474 G/T cg07460842 chr6:66804631 NA -1.14 -17.96 -0.7 6.12e-51 Exhaled nitric oxide output; LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg10150615 chr22:24372951 LOC391322 0.4 6.39 0.33 5.51e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17433780 0.666 rs2624 chr1:89518623 C/T cg09516651 chr1:89888402 LOC400759 -0.59 -11.0 -0.52 3.19e-24 Carotid intima media thickness; LUSC trans rs9329221 0.537 rs12678800 chr8:9978940 G/A cg06636001 chr8:8085503 FLJ10661 0.49 7.29 0.37 2.32e-12 Neuroticism; LUSC cis rs7119038 0.818 rs7942535 chr11:118681464 C/T cg19308663 chr11:118741387 NA -0.32 -5.72 -0.3 2.32e-8 Sjögren's syndrome; LUSC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg12432903 chr7:1882776 MAD1L1 -0.36 -5.83 -0.3 1.29e-8 Bipolar disorder and schizophrenia; LUSC cis rs262150 0.579 rs73167299 chr7:158784367 C/T cg19418458 chr7:158789849 NA 0.52 6.68 0.34 1e-10 Facial morphology (factor 20); LUSC cis rs981844 1.000 rs72731670 chr4:154662471 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.44 0.33 4.05e-10 Response to statins (LDL cholesterol change); LUSC cis rs10911232 0.542 rs12128323 chr1:183050087 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.95 0.51 4.66e-24 Hypertriglyceridemia; LUSC trans rs6104690 1.000 rs6078006 chr20:10986451 T/A cg07172334 chr21:31655261 KRTAP24-1 -0.34 -6.08 -0.32 3.23e-9 Bladder cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11659435 chr20:30310674 BCL2L1 -0.41 -6.39 -0.33 5.49e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg26380479 chr7:97908229 NA -0.27 -6.04 -0.31 4.07e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg15242686 chr22:24348715 GSTTP1 -0.55 -9.11 -0.45 7.83e-18 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7267979 0.586 rs6037057 chr20:25182089 T/C cg08601574 chr20:25228251 PYGB 0.43 6.62 0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5758659 0.714 rs7245 chr22:42481849 G/A cg15557168 chr22:42548783 NA 0.38 6.32 0.33 8.44e-10 Cognitive function; LUSC cis rs4343996 0.558 rs10454314 chr7:3411725 A/G cg21248987 chr7:3385318 SDK1 0.37 6.23 0.32 1.38e-9 Motion sickness; LUSC cis rs4253772 0.591 rs11703245 chr22:46684890 A/G cg18190219 chr22:46762943 CELSR1 -0.55 -6.28 -0.33 1.05e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs711245 0.702 rs1110127 chr2:36768456 G/C cg09467607 chr2:36825704 FEZ2 0.5 10.1 0.48 4.02e-21 Height; LUSC trans rs61931739 0.534 rs1817761 chr12:34105719 C/T cg26384229 chr12:38710491 ALG10B 0.72 11.22 0.52 5.39e-25 Morning vs. evening chronotype; LUSC cis rs9837602 1.000 rs6802422 chr3:99778655 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.12 -0.32 2.58e-9 Breast cancer; LUSC cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg17143192 chr8:8559678 CLDN23 0.63 9.07 0.44 1.02e-17 Obesity-related traits; LUSC cis rs4776059 1.000 rs34431049 chr15:52940538 G/C cg22715398 chr15:52968154 KIAA1370 -0.64 -9.13 -0.45 6.58e-18 Schizophrenia; LUSC cis rs4604732 0.678 rs74154674 chr1:247625685 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg04518342 chr5:131593106 PDLIM4 -0.36 -6.56 -0.34 2.01e-10 Blood metabolite levels; LUSC cis rs9487051 0.743 rs388526 chr6:109543425 C/G cg00509249 chr6:109615579 CCDC162 -0.34 -5.81 -0.3 1.42e-8 Reticulocyte fraction of red cells; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg00431813 chr7:1051703 C7orf50 -0.48 -8.04 -0.4 1.62e-14 Longevity;Endometriosis; LUSC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg07701084 chr6:150067640 NUP43 0.5 7.43 0.38 8.98e-13 Lung cancer; LUSC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg09650180 chr20:62225654 GMEB2 -0.67 -9.66 -0.47 1.23e-19 Glioblastoma; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00087298 chr7:33149137 RP9 0.41 5.98 0.31 5.59e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -6.98 -0.36 1.61e-11 Breast cancer; LUSC trans rs637571 0.522 rs491973 chr11:65727301 A/G cg17712092 chr4:129076599 LARP1B 0.73 10.83 0.51 1.25e-23 Eosinophil percentage of white cells; LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg04518342 chr5:131593106 PDLIM4 0.5 8.89 0.44 3.87e-17 Acylcarnitine levels; LUSC trans rs1864729 1.000 rs2053480 chr8:98278951 A/T cg08679828 chr8:102218111 ZNF706 0.81 7.38 0.37 1.28e-12 Estradiol plasma levels (breast cancer); LUSC cis rs17604090 0.646 rs75322793 chr7:29683176 G/A cg19413766 chr7:29689036 LOC646762 -0.61 -6.95 -0.36 1.97e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs3812762 0.871 rs11603335 chr11:8809844 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.37 6.13 0.32 2.43e-9 Hypospadias; LUSC cis rs12681287 0.752 rs10104242 chr8:87247714 G/C cg27223183 chr8:87520930 FAM82B -0.46 -5.75 -0.3 2.06e-8 Caudate activity during reward; LUSC cis rs698813 0.674 rs6725676 chr2:44497828 T/A cg00619915 chr2:44497795 NA -0.51 -7.16 -0.36 5.33e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg01802117 chr1:53393560 SCP2 0.47 7.57 0.38 3.62e-13 Monocyte count; LUSC cis rs7582180 0.764 rs7425797 chr2:100928337 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.69 -0.43 1.65e-16 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg17366294 chr4:99064904 C4orf37 0.61 10.9 0.51 7.28e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs701145 0.938 rs355778 chr3:154030349 C/T cg17054900 chr3:154042577 DHX36 0.84 8.81 0.43 7.07e-17 Coronary artery disease; LUSC cis rs9612 1.000 rs28446957 chr19:44246600 T/A cg08581076 chr19:44259116 C19orf61 0.54 6.57 0.34 1.88e-10 Exhaled nitric oxide output; LUSC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.76 0.39 1.05e-13 Parkinson's disease; LUSC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC cis rs12541635 0.902 rs13277300 chr8:107062819 C/T cg10147462 chr8:107024639 NA -0.55 -10.03 -0.48 7.49e-21 Age of smoking initiation; LUSC trans rs539514 0.690 rs504273 chr13:76310850 C/T cg05302441 chr11:125157402 PKNOX2 0.26 6.02 0.31 4.7e-9 Type 1 diabetes; LUSC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg27266027 chr21:40555129 PSMG1 -0.4 -5.82 -0.3 1.41e-8 Cognitive function; LUSC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg13560548 chr3:10150139 C3orf24 0.47 6.65 0.34 1.18e-10 Alzheimer's disease; LUSC cis rs6712932 1.000 rs28521663 chr2:105846716 T/C cg22878388 chr2:105853796 NA -0.33 -6.03 -0.31 4.3e-9 Type 2 diabetes; LUSC cis rs6087990 1.000 rs2424900 chr20:31344342 G/C cg13636640 chr20:31349939 DNMT3B 1.04 23.38 0.79 2.63e-72 Ulcerative colitis; LUSC cis rs7267979 1.000 rs2257985 chr20:25269743 G/T cg08601574 chr20:25228251 PYGB 0.43 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2688608 0.933 rs2688614 chr10:75652876 G/A cg23231163 chr10:75533350 FUT11 -0.39 -6.26 -0.32 1.2e-9 Inflammatory bowel disease; LUSC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.84 13.03 0.58 1.12e-31 Cognitive test performance; LUSC cis rs96067 0.740 rs10752586 chr1:36614713 C/G cg24686825 chr1:36642396 MAP7D1 -0.69 -9.25 -0.45 2.78e-18 Corneal structure; LUSC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg12379764 chr21:47803548 PCNT 0.47 6.56 0.34 2.08e-10 Testicular germ cell tumor; LUSC cis rs7119038 0.818 rs10892293 chr11:118665575 A/T cg19308663 chr11:118741387 NA 0.35 6.1 0.32 2.94e-9 Sjögren's syndrome; LUSC cis rs1577917 0.696 rs2842617 chr6:86309698 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -8.84 -0.44 5.69e-17 Response to antipsychotic treatment; LUSC cis rs7312933 0.510 rs1907705 chr12:42451122 T/A cg17420585 chr12:42539391 GXYLT1 -0.55 -12.26 -0.56 8.85e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2652834 0.851 rs2652824 chr15:63420001 C/T cg05507819 chr15:63340323 TPM1 0.47 6.02 0.31 4.65e-9 HDL cholesterol; LUSC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg19468946 chr17:37922297 IKZF3 -0.38 -6.07 -0.32 3.47e-9 Self-reported allergy; LUSC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg24838063 chr12:130822603 PIWIL1 0.69 10.73 0.51 2.84e-23 Menopause (age at onset); LUSC cis rs12042938 0.600 rs1094655 chr1:231774362 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 6.13 0.32 2.43e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs763121 0.889 rs9607557 chr22:39040279 G/A cg06544989 chr22:39130855 UNC84B 0.36 6.43 0.33 4.5e-10 Menopause (age at onset); LUSC cis rs7169223 0.653 rs3971703 chr15:79092481 G/C cg21242079 chr15:79101063 ADAMTS7 0.41 6.25 0.32 1.27e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15945262 chr7:1881887 MAD1L1 0.48 6.12 0.32 2.55e-9 Bipolar disorder and schizophrenia; LUSC cis rs4132509 0.948 rs1458023 chr1:243886673 A/G cg21452805 chr1:244014465 NA 0.52 6.28 0.32 1.07e-9 RR interval (heart rate); LUSC cis rs9392556 0.829 rs617790 chr6:4115758 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.35 -6.14 -0.32 2.31e-9 Blood metabolite levels; LUSC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg14019146 chr3:50243930 SLC38A3 -0.32 -7.17 -0.37 4.86e-12 Intelligence (multi-trait analysis); LUSC cis rs2324229 0.861 rs1180183 chr6:83972041 C/T cg08257003 chr6:84140564 ME1 0.29 6.61 0.34 1.57e-10 Platelet-derived growth factor BB levels; LUSC cis rs925550 0.932 rs6811007 chr4:123585362 A/G cg10495464 chr4:123653540 BBS12;LOC729338 0.64 6.25 0.32 1.26e-9 Primary biliary cholangitis; LUSC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.28 -0.32 1.06e-9 Extrinsic epigenetic age acceleration; LUSC cis rs3087591 0.639 rs1048317 chr17:29704002 T/C cg24425628 chr17:29625626 OMG;NF1 0.5 7.37 0.37 1.31e-12 Hip circumference; LUSC cis rs1783925 1.000 rs610236 chr11:125297925 T/A cg03464685 chr11:125439445 EI24 -0.47 -6.29 -0.33 9.69e-10 Formal thought disorder in schizophrenia; LUSC cis rs3960554 0.808 rs2302434 chr7:75630183 C/T cg17325771 chr7:75508891 RHBDD2 -0.4 -5.79 -0.3 1.66e-8 Eotaxin levels; LUSC cis rs600231 0.690 rs1152619 chr11:65255589 C/A cg17120908 chr11:65337727 SSSCA1 -0.65 -10.71 -0.51 3.39e-23 Bone mineral density; LUSC cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg08754478 chr10:133766260 PPP2R2D -0.6 -7.7 -0.39 1.58e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs61931739 0.534 rs1490113 chr12:34132394 A/G cg06521331 chr12:34319734 NA -0.48 -7.86 -0.39 5.48e-14 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs13217239 0.646 rs7451149 chr6:27057518 A/G cg05738196 chr6:26577821 NA -0.51 -8.14 -0.41 8.1e-15 Schizophrenia; LUSC trans rs1814175 0.867 rs7926002 chr11:49616018 A/G cg15704280 chr7:45808275 SEPT13 -1.09 -20.95 -0.75 8e-63 Height; LUSC cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg12310025 chr6:25882481 NA -0.52 -9.44 -0.46 6.43e-19 Blood metabolite levels; LUSC cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg26373071 chr5:1325741 CLPTM1L 0.38 7.14 0.36 5.92e-12 Lung cancer; LUSC cis rs6599077 0.950 rs6773620 chr3:40100738 T/G cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs28735056 0.660 rs12454454 chr18:77674634 C/T cg05491587 chr18:77659695 KCNG2 0.37 5.8 0.3 1.56e-8 Schizophrenia; LUSC cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg13010199 chr12:38710504 ALG10B 0.49 7.49 0.38 6.08e-13 Drug-induced liver injury (flucloxacillin); LUSC trans rs7395662 0.864 rs10839201 chr11:48989417 A/G cg15704280 chr7:45808275 SEPT13 0.44 6.12 0.32 2.7e-9 HDL cholesterol; LUSC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg09021430 chr5:549028 NA -0.57 -8.23 -0.41 4.36e-15 Obesity-related traits; LUSC cis rs1949733 1.000 rs2688223 chr4:8471398 T/C cg11789530 chr4:8429930 ACOX3 0.62 9.53 0.46 3.26e-19 Response to antineoplastic agents; LUSC cis rs4356932 1.000 rs6532121 chr4:76962606 A/T cg00809888 chr4:76862425 NAAA -0.38 -6.36 -0.33 6.53e-10 Blood protein levels; LUSC cis rs2346177 0.519 rs35509718 chr2:46696793 T/C cg02822958 chr2:46747628 ATP6V1E2 0.47 8.34 0.42 1.94e-15 HDL cholesterol; LUSC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg22823121 chr1:150693482 HORMAD1 0.47 7.0 0.36 1.44e-11 Melanoma; LUSC trans rs11098499 0.954 rs71629403 chr4:120372567 C/T cg25214090 chr10:38739885 LOC399744 0.56 8.19 0.41 5.49e-15 Corneal astigmatism; LUSC trans rs9747201 0.926 rs35131420 chr17:80103631 T/C cg07393940 chr7:158741817 NA -0.51 -8.09 -0.4 1.12e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4363385 0.510 rs11588463 chr1:152901984 T/C cg25856811 chr1:152973957 SPRR3 -0.39 -6.35 -0.33 7.09e-10 Inflammatory skin disease; LUSC cis rs4285028 0.699 rs1574115 chr3:121469225 T/C cg11130432 chr3:121712080 ILDR1 -0.61 -8.71 -0.43 1.48e-16 Multiple sclerosis; LUSC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg00049323 chr5:472564 LOC25845 -0.44 -6.8 -0.35 4.79e-11 Cystic fibrosis severity; LUSC cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.51 -0.46 4.02e-19 Chronic sinus infection; LUSC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg17279839 chr7:150038598 RARRES2 0.43 6.9 0.35 2.58e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg01879757 chr17:41196368 BRCA1 -0.47 -7.26 -0.37 2.74e-12 Menopause (age at onset); LUSC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg23630131 chr7:65973040 NA -0.2 -5.67 -0.3 3.15e-8 Aortic root size; LUSC cis rs12545109 0.800 rs1467126 chr8:57418452 C/T cg09654669 chr8:57350985 NA -0.56 -7.78 -0.39 9.24e-14 Obesity-related traits; LUSC cis rs9814567 0.752 rs6764764 chr3:134331167 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.71 11.06 0.52 2e-24 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg23625390 chr15:77176239 SCAPER 0.45 6.9 0.35 2.55e-11 Blood metabolite levels; LUSC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg08219700 chr8:58056026 NA 0.51 6.35 0.33 7.03e-10 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg10523679 chr1:76189770 ACADM 0.8 10.9 0.51 7.21e-24 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs62238980 0.614 rs117959136 chr22:32373225 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs6840360 0.550 rs7689266 chr4:152561048 T/C cg22705602 chr4:152727874 NA -0.31 -6.17 -0.32 1.98e-9 Intelligence (multi-trait analysis); LUSC cis rs7107174 0.688 rs881361 chr11:78128047 C/G cg02023728 chr11:77925099 USP35 0.43 6.58 0.34 1.77e-10 Testicular germ cell tumor; LUSC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg15704280 chr7:45808275 SEPT13 -1.08 -19.9 -0.74 1.14e-58 Coronary artery disease; LUSC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg04414720 chr1:150670196 GOLPH3L -0.47 -7.22 -0.37 3.52e-12 Urate levels; LUSC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg13206674 chr6:150067644 NUP43 0.64 10.55 0.5 1.15e-22 Lung cancer; LUSC cis rs12220238 1.000 rs10824083 chr10:75911342 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.27 0.37 2.65e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9467773 1.000 rs6930120 chr6:26555484 A/G cg11502198 chr6:26597334 ABT1 0.62 9.85 0.47 2.95e-20 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs1909765 chr16:48597358 A/G cg04672837 chr16:48644449 N4BP1 0.43 6.41 0.33 4.9e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs478304 0.934 rs537786 chr11:65494987 C/T cg27068330 chr11:65405492 SIPA1 0.64 9.61 0.47 1.85e-19 Acne (severe); LUSC cis rs2197308 0.715 rs11181816 chr12:37911626 A/G cg13010199 chr12:38710504 ALG10B -0.6 -9.33 -0.45 1.56e-18 Morning vs. evening chronotype; LUSC cis rs4664308 0.658 rs12987602 chr2:160960788 G/T cg03641300 chr2:160917029 PLA2R1 -0.62 -10.19 -0.49 2.01e-21 Idiopathic membranous nephropathy; LUSC cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.67 -0.3 3.15e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs11190604 1.000 rs7477246 chr10:102261538 C/T cg07080220 chr10:102295463 HIF1AN 0.68 9.14 0.45 6.2e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -7.29 -0.37 2.23e-12 Developmental language disorder (linguistic errors); LUSC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg06212747 chr3:49208901 KLHDC8B 0.63 8.85 0.44 5.22e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC trans rs459571 0.920 rs460154 chr9:136909309 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -12.47 -0.56 1.41e-29 Platelet distribution width; LUSC cis rs9640161 0.617 rs56019796 chr7:150009226 T/C cg21361702 chr7:150065534 REPIN1 0.43 6.11 0.32 2.74e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs3740713 1.000 rs12289603 chr11:18471370 T/C cg07915343 chr11:18477680 LDHAL6A -0.56 -7.14 -0.36 5.8e-12 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg04117972 chr1:227635322 NA -0.59 -6.77 -0.35 5.71e-11 Major depressive disorder; LUSC cis rs929596 0.793 rs2741045 chr2:234580140 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -6.82 -0.35 4.22e-11 Total bilirubin levels in HIV-1 infection; LUSC trans rs7939886 0.920 rs58405266 chr11:55863225 G/A cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.22e-10 Myopia (pathological); LUSC cis rs9303280 0.617 rs8079416 chr17:38092713 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.35 -5.66 -0.3 3.22e-8 Self-reported allergy; LUSC cis rs35883536 0.626 rs10493933 chr1:101111282 A/G cg06223162 chr1:101003688 GPR88 -0.43 -7.51 -0.38 5.39e-13 Monocyte count; LUSC cis rs478304 0.619 rs10791822 chr11:65428706 T/C cg27068330 chr11:65405492 SIPA1 -0.76 -10.78 -0.51 1.92e-23 Acne (severe); LUSC cis rs67696533 0.871 rs159058 chr20:31108108 A/C cg13636640 chr20:31349939 DNMT3B 0.42 6.09 0.32 3.04e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs3858526 0.834 rs7116627 chr11:5985550 T/C cg25319279 chr11:5960081 NA -0.46 -6.47 -0.33 3.48e-10 DNA methylation (variation); LUSC cis rs6542838 0.641 rs4850890 chr2:99535426 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -6.05 -0.31 3.92e-9 Fear of minor pain; LUSC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg18876405 chr7:65276391 NA -0.71 -12.33 -0.56 4.93e-29 Aortic root size; LUSC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.11 0.48 3.78e-21 Bipolar disorder; LUSC cis rs9326248 0.581 rs10892076 chr11:116988936 G/A cg16524733 chr11:117070046 TAGLN 0.33 6.14 0.32 2.4e-9 Blood protein levels; LUSC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.65 13.79 0.6 1.52e-34 Monocyte percentage of white cells; LUSC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg11861562 chr11:117069780 TAGLN 0.44 7.91 0.4 3.75e-14 Blood protein levels; LUSC cis rs28829049 0.536 rs12405382 chr1:19548981 C/T cg13387374 chr1:19411106 UBR4 0.43 5.7 0.3 2.64e-8 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs11158026 0.603 rs34988865 chr14:55474849 T/C cg04306507 chr14:55594613 LGALS3 0.39 7.2 0.37 4.06e-12 Parkinson's disease; LUSC cis rs2249625 0.545 rs2463743 chr6:72874741 C/T cg18830697 chr6:72922368 RIMS1 -0.36 -7.2 -0.37 4.04e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg08270630 chr22:50330655 NA -0.53 -6.74 -0.35 7.12e-11 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24715260 chr17:80056221 FASN -0.44 -6.69 -0.34 9.21e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs877282 0.945 rs11253391 chr10:788752 G/A cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs754466 1.000 rs12220311 chr10:79681507 C/T cg17075019 chr10:79541650 NA -0.64 -8.4 -0.42 1.32e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg26818010 chr10:134567672 INPP5A -0.86 -11.07 -0.52 1.83e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs10435719 0.773 rs7842810 chr8:11794163 A/G cg15556689 chr8:8085844 FLJ10661 0.56 8.47 0.42 7.67e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs925255 0.743 rs4426489 chr2:28639641 C/G cg01273330 chr2:28605224 NA -0.43 -6.89 -0.35 2.84e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg11764359 chr7:65958608 NA 0.66 10.4 0.49 3.85e-22 Aortic root size; LUSC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg04455712 chr21:45112962 RRP1B 0.48 8.94 0.44 2.77e-17 Mean corpuscular volume; LUSC cis rs7512552 0.809 rs2794679 chr1:150324857 G/A cg15654264 chr1:150340011 RPRD2 0.64 10.58 0.5 9.37e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 2.02e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg21984481 chr17:79567631 NPLOC4 -0.56 -10.74 -0.51 2.6e-23 Eye color traits; LUSC cis rs9653442 0.527 rs10185059 chr2:100790172 C/T cg22139774 chr2:100720529 AFF3 -0.41 -7.14 -0.36 5.74e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs2282970 chr7:91584281 A/G cg17063962 chr7:91808500 NA 0.56 9.04 0.44 1.3e-17 Breast cancer; LUSC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg12927641 chr6:109611667 NA -0.34 -5.8 -0.3 1.53e-8 Reticulocyte fraction of red cells; LUSC cis rs11077998 1.000 rs11077998 chr17:80483946 C/G cg10255544 chr17:80519551 FOXK2 -0.39 -6.35 -0.33 7.02e-10 Reticulocyte fraction of red cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07199032 chr16:23607617 NDUFAB1 -0.41 -6.04 -0.31 4.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg19920283 chr7:105172520 RINT1 0.62 6.94 0.36 2.04e-11 Bipolar disorder (body mass index interaction); LUSC cis rs6545883 0.929 rs2593627 chr2:61618574 T/C cg15711740 chr2:61764176 XPO1 0.42 6.49 0.33 3.17e-10 Tuberculosis; LUSC cis rs4604732 0.527 rs7546805 chr1:247627259 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs208520 0.754 rs1100989 chr6:66880532 G/A cg07460842 chr6:66804631 NA -1.11 -16.94 -0.68 6.59e-47 Exhaled nitric oxide output; LUSC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg26855724 chr1:75198818 TYW3;CRYZ 0.46 7.16 0.36 5.2e-12 Resistin levels; LUSC cis rs6460942 0.731 rs7799372 chr7:12233784 T/A cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs6499755 0.932 rs714507 chr16:55339777 C/T cg02859129 chr16:55357253 IRX6 0.33 5.68 0.3 2.97e-8 Hypospadias; LUSC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg00631329 chr6:26305371 NA 0.33 5.76 0.3 1.88e-8 Intelligence (multi-trait analysis); LUSC trans rs1973993 0.507 rs2759670 chr1:97002864 A/G cg10631902 chr5:14652156 NA 0.47 7.53 0.38 4.85e-13 Weight; LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg00080972 chr5:178986291 RUFY1 0.66 12.68 0.57 2.39e-30 Lung cancer; LUSC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -6.45 -0.33 3.85e-10 Breast cancer; LUSC cis rs11155671 0.530 rs9322228 chr6:150209309 C/G cg07701084 chr6:150067640 NUP43 0.46 6.93 0.35 2.23e-11 Testicular germ cell tumor; LUSC cis rs9527 0.590 rs3781282 chr10:104852419 C/T cg05855489 chr10:104503620 C10orf26 -0.52 -8.04 -0.4 1.52e-14 Arsenic metabolism; LUSC cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg00677455 chr12:58241039 CTDSP2 0.62 8.93 0.44 2.89e-17 Multiple sclerosis; LUSC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg22496339 chr2:162101262 NA 0.74 11.98 0.55 9.48e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg17366294 chr4:99064904 C4orf37 0.55 9.67 0.47 1.18e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.74 0.35 7.17e-11 Lung cancer; LUSC cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg13246856 chr1:44399776 ARTN 0.35 7.39 0.37 1.18e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs7712401 0.580 rs35902490 chr5:122323398 G/T cg19077854 chr5:122220652 SNX24 -0.43 -9.48 -0.46 4.83e-19 Mean platelet volume; LUSC cis rs3850699 0.683 rs67481356 chr10:104317811 C/A cg05855489 chr10:104503620 C10orf26 0.64 8.99 0.44 1.87e-17 Prostate cancer; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg00431813 chr7:1051703 C7orf50 -0.47 -7.82 -0.39 7.03e-14 Longevity;Endometriosis; LUSC cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg13319975 chr6:146136371 FBXO30 0.5 7.52 0.38 5.2e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg26384229 chr12:38710491 ALG10B 0.88 15.01 0.63 2.73e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg05738196 chr6:26577821 NA 0.52 8.3 0.41 2.53e-15 Schizophrenia; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01171360 chr6:293285 DUSP22 0.72 12.04 0.55 5.76e-28 Menopause (age at onset); LUSC cis rs354225 0.544 rs10205410 chr2:54799599 G/T cg01766943 chr2:54829624 SPTBN1 0.45 6.99 0.36 1.51e-11 Schizophrenia; LUSC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg14019146 chr3:50243930 SLC38A3 0.36 8.26 0.41 3.53e-15 Body mass index; LUSC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.67e-9 Monocyte count; LUSC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg22437258 chr11:111473054 SIK2 0.52 7.08 0.36 8.73e-12 Primary sclerosing cholangitis; LUSC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg05425664 chr17:57184151 TRIM37 0.56 8.34 0.42 1.94e-15 Intelligence (multi-trait analysis); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07573057 chr8:82754234 SNX16 -0.45 -6.02 -0.31 4.66e-9 Hepatitis; LUSC cis rs9905704 0.681 rs4277402 chr17:56581651 C/G cg19466818 chr17:56409534 MIR142 0.37 6.97 0.36 1.74e-11 Testicular germ cell tumor; LUSC cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.72e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg06008330 chr7:65541103 ASL 0.39 6.13 0.32 2.42e-9 Aortic root size; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25660386 chr3:13009126 IQSEC1 0.42 5.98 0.31 5.75e-9 Mosquito bite size; LUSC cis rs977987 0.836 rs4888376 chr16:75322573 T/C cg04384234 chr16:75411784 CFDP1 -0.38 -5.97 -0.31 5.94e-9 Dupuytren's disease; LUSC cis rs10740039 1.000 rs10761543 chr10:62415391 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.36e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9469578 0.579 rs73743309 chr6:33683548 A/G cg18708504 chr6:33715942 IP6K3 0.67 6.33 0.33 8e-10 Phosphorus levels; LUSC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg22655196 chr4:3374909 RGS12 0.31 5.85 0.31 1.14e-8 Serum sulfate level; LUSC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg06238570 chr21:40685208 BRWD1 -0.59 -9.21 -0.45 3.78e-18 Menarche (age at onset); LUSC cis rs1784581 0.588 rs9295178 chr6:162419226 T/A cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.09e-20 Itch intensity from mosquito bite; LUSC cis rs11997175 0.646 rs4593495 chr8:33692649 C/T ch.8.33884649F chr8:33765107 NA 0.45 6.62 0.34 1.41e-10 Body mass index; LUSC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.31 -0.33 8.8e-10 Lung cancer; LUSC cis rs4363385 0.747 rs1415960 chr1:152973571 G/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.67 -0.3 3.09e-8 Inflammatory skin disease; LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -6.15 -0.32 2.24e-9 Developmental language disorder (linguistic errors); LUSC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg12310025 chr6:25882481 NA 0.42 7.02 0.36 1.27e-11 Intelligence (multi-trait analysis); LUSC cis rs6700896 0.966 rs4655557 chr1:66080787 T/C cg04111102 chr1:66153794 NA 0.3 6.61 0.34 1.5e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6121246 0.909 rs6119725 chr20:30385557 G/T cg18721089 chr20:30220636 NA -0.35 -6.05 -0.31 3.82e-9 Mean corpuscular hemoglobin; LUSC cis rs12701220 0.597 rs10253153 chr7:1001974 G/A cg04102894 chr7:1000210 NA -0.28 -6.44 -0.33 4.07e-10 Bronchopulmonary dysplasia; LUSC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg05340658 chr4:99064831 C4orf37 0.64 10.42 0.5 3.48e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg00933542 chr6:150070202 PCMT1 -0.32 -6.54 -0.34 2.25e-10 Lung cancer; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg14047339 chr6:45345544 RUNX2;SUPT3H -0.38 -6.41 -0.33 4.86e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg15839431 chr19:19639596 YJEFN3 -0.63 -7.1 -0.36 7.36e-12 Bipolar disorder; LUSC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.74 0.35 6.9e-11 Schizophrenia; LUSC cis rs6693567 0.565 rs1260407 chr1:150306125 T/C cg15654264 chr1:150340011 RPRD2 0.44 7.02 0.36 1.22e-11 Migraine; LUSC trans rs561341 0.609 rs2051810 chr17:30195841 C/T cg20587970 chr11:113659929 NA 0.82 9.9 0.48 2.02e-20 Hip circumference adjusted for BMI; LUSC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg18404041 chr3:52824283 ITIH1 -0.51 -9.69 -0.47 1e-19 Bipolar disorder; LUSC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg13685155 chr2:88473871 THNSL2 0.36 5.7 0.3 2.6e-8 Response to metformin (IC50); LUSC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg15649852 chr7:65879115 NA -0.41 -5.76 -0.3 1.96e-8 Aortic root size; LUSC cis rs1005224 0.963 rs11626062 chr14:76136329 T/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.4 -5.88 -0.31 1.01e-8 Large artery stroke; LUSC trans rs2797160 1.000 rs1418951 chr6:125996185 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.5 -0.34 2.9e-10 Endometrial cancer; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg11062466 chr8:58055876 NA 0.72 8.93 0.44 2.94e-17 Developmental language disorder (linguistic errors); LUSC trans rs10838798 0.504 rs7479393 chr11:48295303 G/C cg03929089 chr4:120376271 NA -0.44 -6.11 -0.32 2.71e-9 Height; LUSC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg13390004 chr1:15929781 NA 0.42 7.04 0.36 1.07e-11 Systolic blood pressure; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg22476893 chr17:7210162 EIF5A 0.39 5.98 0.31 5.82e-9 Triglycerides; LUSC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.47 7.33 0.37 1.77e-12 Alzheimer's disease (late onset); LUSC cis rs4842666 0.915 rs11105368 chr12:90074441 G/C cg00757033 chr12:89920650 WDR51B 0.49 7.05 0.36 1.02e-11 Blood pressure; LUSC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.73 0.43 1.22e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs6674970 0.966 rs4512652 chr1:151115690 G/C cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.46 -6.18 -0.32 1.89e-9 Childhood ear infection; LUSC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs6089584 0.893 rs2281735 chr20:60582540 T/A cg16423285 chr20:60520624 NA -0.44 -5.67 -0.3 3.14e-8 Body mass index; LUSC cis rs7216064 1.000 rs62084238 chr17:65856573 T/A cg12091567 chr17:66097778 LOC651250 -0.74 -9.27 -0.45 2.4e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs8060686 0.641 rs2418737 chr16:68122726 T/C cg26727032 chr16:67993705 SLC12A4 -0.42 -5.84 -0.3 1.21e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs34779708 0.966 rs2045915 chr10:35418616 G/C cg03585969 chr10:35415529 CREM 0.59 8.79 0.43 8.14e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6977660 1.000 rs714239 chr7:19803944 C/T cg05791153 chr7:19748676 TWISTNB 0.55 6.16 0.32 2.05e-9 Thyroid stimulating hormone; LUSC cis rs1595825 0.945 rs73058813 chr2:198858268 A/G cg10547527 chr2:198650123 BOLL -0.49 -5.71 -0.3 2.49e-8 Ulcerative colitis; LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg20607798 chr8:58055168 NA 0.52 5.66 0.3 3.33e-8 Developmental language disorder (linguistic errors); LUSC cis rs3862435 0.764 rs7181764 chr15:91050771 G/A cg22089800 chr15:90895588 ZNF774 -0.56 -6.02 -0.31 4.67e-9 Response to exercise (triglyceride level interaction); LUSC cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg17515076 chr17:73810948 UNK -0.39 -6.55 -0.34 2.14e-10 White matter hyperintensity burden; LUSC cis rs1878931 0.543 rs1129568 chr16:3483475 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 14.98 0.63 3.51e-39 Body mass index (adult); LUSC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg05802129 chr4:122689817 NA -0.52 -8.75 -0.43 1.04e-16 Type 2 diabetes; LUSC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg22920501 chr2:26401640 FAM59B -0.72 -10.3 -0.49 8.65e-22 Gut microbiome composition (summer); LUSC cis rs728616 0.558 rs12767261 chr10:82162323 G/A cg05935833 chr10:81318306 SFTPA2 -0.44 -5.8 -0.3 1.57e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs921968 0.565 rs12694439 chr2:219590871 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.3 -0.49 8.75e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg06634786 chr22:41940651 POLR3H 0.52 6.16 0.32 2.11e-9 Vitiligo; LUSC cis rs7575217 0.622 rs12466496 chr2:101768115 T/C cg23907051 chr2:101730305 TBC1D8 -0.3 -7.85 -0.39 5.65e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs9902453 0.967 rs55748380 chr17:28469782 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 8.08 0.4 1.17e-14 Coffee consumption (cups per day); LUSC cis rs9393777 0.920 rs41269265 chr6:27425349 T/C cg26958806 chr6:27640298 NA 0.74 5.93 0.31 7.37e-9 Intelligence (multi-trait analysis); LUSC trans rs3857536 0.813 rs6455091 chr6:66949127 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg26513180 chr16:89883248 FANCA 0.91 17.79 0.7 2.82e-50 Vitiligo; LUSC trans rs61931739 0.635 rs1352208 chr12:33932543 T/C cg26384229 chr12:38710491 ALG10B 0.51 7.63 0.39 2.51e-13 Morning vs. evening chronotype; LUSC cis rs7267979 0.739 rs6138555 chr20:25242910 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.69 13.07 0.58 7.94e-32 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg05855489 chr10:104503620 C10orf26 0.59 9.42 0.46 7.63e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs16976116 0.901 rs1061824 chr15:55495963 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg09359103 chr1:154839909 KCNN3 -0.69 -15.84 -0.65 1.53e-42 Prostate cancer; LUSC cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg26384229 chr12:38710491 ALG10B 0.84 14.45 0.62 4.06e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs7121446 0.520 rs7943463 chr11:121850960 T/C cg13820391 chr11:121835505 NA 0.37 6.15 0.32 2.21e-9 Cardiovascular risk factors (age interaction); LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg22166914 chr1:53195759 ZYG11B 0.6 9.82 0.47 3.58e-20 Monocyte count; LUSC cis rs4664308 0.967 rs56293836 chr2:160910958 T/C cg03641300 chr2:160917029 PLA2R1 -0.67 -11.33 -0.53 2.16e-25 Idiopathic membranous nephropathy; LUSC cis rs58688157 0.960 rs12422022 chr11:613192 A/G cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 4.92e-10 Systemic lupus erythematosus; LUSC cis rs870825 0.655 rs28451943 chr4:185645572 C/T cg04058563 chr4:185651563 MLF1IP 0.82 12.63 0.57 3.7e-30 Blood protein levels; LUSC cis rs2439831 0.850 rs61390361 chr15:44159842 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.52 0.42 5.66e-16 Lung cancer in ever smokers; LUSC cis rs9420 0.961 rs12146541 chr11:57508678 G/C cg23127183 chr11:57508653 C11orf31 -0.58 -8.94 -0.44 2.65e-17 Schizophrenia; LUSC cis rs9354308 0.901 rs12197136 chr6:66590953 T/C cg07460842 chr6:66804631 NA 0.47 5.78 0.3 1.71e-8 Metabolite levels; LUSC cis rs6163 0.540 rs11191385 chr10:104513049 G/T cg04362960 chr10:104952993 NT5C2 0.51 7.17 0.37 4.83e-12 Waist circumference;Hip circumference; LUSC cis rs2637266 1.000 rs12413656 chr10:78379666 A/C cg18941641 chr10:78392320 NA 0.41 7.43 0.38 9.3e-13 Pulmonary function; LUSC cis rs6669072 0.703 rs3843306 chr1:91288130 A/T cg08895590 chr1:91227319 NA 0.34 7.56 0.38 4.05e-13 Cognitive function; LUSC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg06219351 chr7:158114137 PTPRN2 -0.51 -9.28 -0.45 2.14e-18 Calcium levels; LUSC cis rs9300255 0.602 rs2682431 chr12:123703226 T/A cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs9329221 0.710 rs11249995 chr8:10238922 T/C cg27411982 chr8:10470053 RP1L1 0.42 6.05 0.31 3.89e-9 Neuroticism; LUSC cis rs2898681 0.567 rs77657787 chr4:53729981 G/A cg00791764 chr4:53727839 RASL11B 0.57 7.24 0.37 3.1e-12 Optic nerve measurement (cup area); LUSC cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg16145915 chr7:1198662 ZFAND2A -0.42 -7.63 -0.39 2.54e-13 Longevity;Endometriosis; LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs981844 0.775 rs1037656 chr4:154750786 A/G cg14289246 chr4:154710475 SFRP2 -0.49 -6.73 -0.35 7.37e-11 Response to statins (LDL cholesterol change); LUSC cis rs6546550 0.901 rs7573442 chr2:70154037 G/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.31 -0.37 2.02e-12 Prevalent atrial fibrillation; LUSC cis rs2067615 0.579 rs9651957 chr12:107170128 A/G cg15890332 chr12:107067104 RFX4 0.33 6.06 0.31 3.76e-9 Heart rate; LUSC cis rs4862307 0.623 rs11730046 chr4:184988245 C/G cg06737308 chr4:185021514 ENPP6 0.48 7.06 0.36 9.93e-12 Serum dimethylarginine levels (asymmetric/symetric ratio); LUSC cis rs977987 0.778 rs2865528 chr16:75455942 T/C cg03315344 chr16:75512273 CHST6 0.54 10.31 0.49 7.88e-22 Dupuytren's disease; LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.34 0.33 7.36e-10 Menopause (age at onset); LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg00149659 chr3:10157352 C3orf10 0.91 11.8 0.54 4.3e-27 Alzheimer's disease; LUSC cis rs3916 0.910 rs7306541 chr12:121130046 A/G cg27246729 chr12:121163418 ACADS 0.48 6.98 0.36 1.58e-11 Urinary metabolites (H-NMR features); LUSC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg19774624 chr17:42201019 HDAC5 0.7 10.35 0.49 5.79e-22 Total body bone mineral density; LUSC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg24733560 chr20:60626293 TAF4 -0.39 -6.15 -0.32 2.16e-9 Body mass index; LUSC cis rs35995292 0.517 rs6948026 chr7:38920854 A/G cg19327137 chr7:38886074 VPS41 0.55 10.26 0.49 1.21e-21 Subjective well-being (multi-trait analysis); LUSC trans rs28735056 0.967 rs623546 chr18:77595228 C/T cg05926928 chr17:57297772 GDPD1 -0.48 -6.66 -0.34 1.11e-10 Schizophrenia; LUSC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg03929089 chr4:120376271 NA -0.93 -16.14 -0.66 9.76e-44 Height; LUSC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg17971929 chr21:40555470 PSMG1 -0.49 -7.12 -0.36 6.67e-12 Menarche (age at onset); LUSC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg15445000 chr17:37608096 MED1 0.41 6.84 0.35 3.85e-11 Glomerular filtration rate (creatinine); LUSC cis rs12137294 0.866 rs1172140 chr1:205213024 G/A cg21643547 chr1:205240462 TMCC2 -0.35 -6.33 -0.33 7.82e-10 Red cell distribution width; LUSC trans rs62103177 0.564 rs3930042 chr18:77723843 G/A cg05926928 chr17:57297772 GDPD1 1.0 11.17 0.52 7.71e-25 Opioid sensitivity; LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.93 0.31 7.63e-9 Menopause (age at onset); LUSC cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg11244672 chr19:19639970 YJEFN3 -0.57 -6.94 -0.36 2.02e-11 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15558129 chr1:219347279 LYPLAL1 0.42 6.0 0.31 5.18e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7904368 0.951 rs7905776 chr10:16853609 C/T cg23933602 chr10:16859644 RSU1 0.63 8.32 0.41 2.33e-15 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs611744 0.810 rs672161 chr8:109164182 G/A cg18478394 chr8:109455254 TTC35 0.42 6.32 0.33 8.15e-10 Dupuytren's disease; LUSC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg01973587 chr1:228161476 NA 0.47 8.51 0.42 6.05e-16 Diastolic blood pressure; LUSC cis rs394563 0.622 rs237024 chr6:149721965 T/C cg07828024 chr6:149772892 ZC3H12D -0.34 -7.38 -0.37 1.26e-12 Dupuytren's disease; LUSC cis rs782590 0.764 rs935177 chr2:55826761 C/G cg18811423 chr2:55921094 PNPT1 0.77 12.76 0.57 1.2e-30 Metabolic syndrome; LUSC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg19230755 chr7:65878503 NA 0.44 6.19 0.32 1.74e-9 Aortic root size; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26143820 chr14:100071437 CCDC85C -0.4 -6.35 -0.33 7.12e-10 Electrocardiographic conduction measures; LUSC cis rs35123781 1.000 rs599946 chr5:139057461 A/G cg10513866 chr5:139070639 NA 0.46 8.9 0.44 3.62e-17 Schizophrenia; LUSC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg24642844 chr7:1081250 C7orf50 -0.7 -9.66 -0.47 1.25e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.38 5.73 0.3 2.24e-8 Schizophrenia; LUSC cis rs12594515 1.000 rs8032361 chr15:45988553 T/C cg01629716 chr15:45996671 NA 0.4 6.06 0.31 3.68e-9 Waist circumference;Weight; LUSC cis rs11690935 0.527 rs7586556 chr2:172901887 G/C cg13550731 chr2:172543902 DYNC1I2 0.52 8.08 0.4 1.22e-14 Schizophrenia; LUSC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg20203395 chr5:56204925 C5orf35 -0.6 -8.44 -0.42 1.01e-15 Coronary artery disease; LUSC trans rs877282 1.000 rs877282 chr10:771532 G/A cg22713356 chr15:30763199 NA 1.1 15.13 0.64 9.03e-40 Uric acid levels; LUSC cis rs6714710 0.603 rs11691494 chr2:98419726 T/A cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.44 0.53 8.49e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs7089973 0.604 rs11196942 chr10:116596872 G/A cg03647239 chr10:116582469 FAM160B1 0.43 6.97 0.36 1.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs2307022 0.530 rs3826166 chr16:68388781 C/G cg02226672 chr16:68398533 SMPD3 0.3 5.68 0.3 2.93e-8 Body mass index; LUSC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg06718696 chr17:78121285 EIF4A3 0.45 6.4 0.33 5.31e-10 Yeast infection; LUSC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs62432291 0.681 rs431205 chr6:159662499 A/G cg14500486 chr6:159655392 FNDC1 -0.54 -6.07 -0.32 3.39e-9 Joint mobility (Beighton score); LUSC cis rs2486288 0.656 rs9921025 chr15:45546602 G/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -8.0 -0.4 2.03e-14 Glomerular filtration rate; LUSC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg13206674 chr6:150067644 NUP43 0.6 9.7 0.47 9.47e-20 Lung cancer; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.87 0.54 2.36e-27 Prudent dietary pattern; LUSC cis rs7727544 0.716 rs11949055 chr5:131576737 T/C cg24060327 chr5:131705240 SLC22A5 -0.39 -6.48 -0.33 3.28e-10 Blood metabolite levels; LUSC cis rs1034435 0.755 rs5767172 chr22:48892314 A/C cg05992904 chr22:48892994 FAM19A5 -0.42 -8.24 -0.41 3.85e-15 Late-onset Alzheimer's disease; LUSC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2070488 0.662 rs7375040 chr3:38469116 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 10.35 0.49 5.83e-22 Electrocardiographic conduction measures; LUSC cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg03146154 chr1:46216737 IPP -0.5 -7.26 -0.37 2.69e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs475616 1.000 rs503598 chr10:30496125 A/G cg02841571 chr6:169977833 WDR27 -0.43 -6.22 -0.32 1.52e-9 Monocyte count; LUSC cis rs10789491 0.565 rs2897107 chr1:47206178 A/T cg15501359 chr1:47185051 KIAA0494 0.78 10.13 0.48 3.24e-21 Response to hepatitis C treatment; LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg00149659 chr3:10157352 C3orf10 1.0 14.77 0.63 2.33e-38 Alzheimer's disease; LUSC cis rs7615316 0.836 rs6768093 chr3:142298200 A/T cg16271453 chr3:142027066 XRN1 -0.36 -6.03 -0.31 4.46e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg23093090 chr10:104574429 C10orf26 -0.38 -7.03 -0.36 1.14e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg07507251 chr3:52567010 NT5DC2 0.33 6.51 0.34 2.78e-10 Bipolar disorder; LUSC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg06238570 chr21:40685208 BRWD1 0.46 7.05 0.36 1.02e-11 Cognitive function; LUSC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg06212747 chr3:49208901 KLHDC8B 0.44 5.98 0.31 5.79e-9 Parkinson's disease; LUSC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg11905131 chr22:24372483 LOC391322 -0.5 -8.56 -0.42 4.13e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.16 -0.45 5.33e-18 Gut microbiome composition (summer); LUSC cis rs10911251 0.546 rs10911267 chr1:183115323 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.59 0.5 8.72e-23 Colorectal cancer; LUSC cis rs1113500 1.000 rs1777483 chr1:108609408 A/C cg06207961 chr1:108661230 NA -0.39 -7.01 -0.36 1.29e-11 Growth-regulated protein alpha levels; LUSC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg13531842 chr10:38383804 ZNF37A -0.45 -7.08 -0.36 8.53e-12 Extrinsic epigenetic age acceleration; LUSC cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg11244672 chr19:19639970 YJEFN3 -0.53 -6.54 -0.34 2.26e-10 Bipolar disorder; LUSC cis rs17253792 0.732 rs10146604 chr14:56045770 C/G cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs136211 0.577 rs9607339 chr22:36768932 G/T cg21778268 chr22:36877729 TXN2 -0.42 -6.01 -0.31 4.98e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg00684032 chr4:1343700 KIAA1530 0.44 7.77 0.39 9.69e-14 Obesity-related traits; LUSC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg22437258 chr11:111473054 SIK2 0.46 6.15 0.32 2.21e-9 Primary sclerosing cholangitis; LUSC cis rs9467773 1.000 rs9461271 chr6:26554968 G/A cg05738196 chr6:26577821 NA 0.83 16.11 0.66 1.29e-43 Intelligence (multi-trait analysis); LUSC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.47 7.3 0.37 2.13e-12 Colorectal cancer; LUSC cis rs7605827 0.930 rs6749063 chr2:15565278 T/G cg19274914 chr2:15703543 NA 0.47 8.97 0.44 2.17e-17 Educational attainment (years of education); LUSC cis rs2404602 0.692 rs7163397 chr15:76940315 A/G cg23625390 chr15:77176239 SCAPER 0.45 6.9 0.35 2.55e-11 Blood metabolite levels; LUSC cis rs5753618 0.561 rs4141404 chr22:31675185 A/C cg22777020 chr22:31556080 RNF185 -0.47 -5.94 -0.31 7.04e-9 Colorectal cancer; LUSC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs868036 0.718 rs922494 chr15:68120644 T/C cg08079166 chr15:68083412 MAP2K5 0.42 7.47 0.38 6.94e-13 Restless legs syndrome; LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg19346786 chr7:2764209 NA 0.5 8.73 0.43 1.22e-16 Height; LUSC cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg05855489 chr10:104503620 C10orf26 -0.53 -8.09 -0.4 1.13e-14 Arsenic metabolism; LUSC cis rs28647808 0.786 rs28649804 chr9:136257709 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs9611519 0.964 rs20551 chr22:41548008 A/G cg03806693 chr22:41940476 POLR3H -0.56 -7.76 -0.39 1.03e-13 Neuroticism; LUSC cis rs10911232 0.507 rs10911230 chr1:183051118 A/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.08 0.52 1.71e-24 Hypertriglyceridemia; LUSC cis rs834603 0.575 rs2665775 chr7:47465387 C/T cg09696706 chr7:47479511 TNS3 0.32 5.7 0.3 2.6e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs2227564 0.729 rs2633303 chr10:75645882 G/T cg23231163 chr10:75533350 FUT11 -0.44 -6.11 -0.32 2.85e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg01411255 chr17:61851458 DDX42;CCDC47 1.02 20.81 0.75 2.85e-62 Height; LUSC trans rs941408 0.928 rs2260414 chr19:2796316 G/A cg22153745 chr1:153894579 GATAD2B -0.57 -8.89 -0.44 3.8e-17 Total cholesterol levels; LUSC cis rs1348850 0.526 rs10930797 chr2:178437553 C/G cg27490568 chr2:178487706 NA 0.4 5.8 0.3 1.55e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6574644 1.000 rs8010545 chr14:81778787 G/C cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs7580658 0.963 rs4233584 chr2:128060163 C/T cg09760422 chr2:128146352 NA -0.33 -7.27 -0.37 2.51e-12 Protein C levels; LUSC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg04369109 chr6:150039330 LATS1 -0.56 -8.28 -0.41 2.98e-15 Lung cancer; LUSC cis rs7107174 0.892 rs12281104 chr11:78046940 T/C cg02023728 chr11:77925099 USP35 0.45 6.85 0.35 3.49e-11 Testicular germ cell tumor; LUSC cis rs3931020 0.688 rs277374 chr1:75200486 G/A cg00121533 chr1:75199117 CRYZ;TYW3 -0.47 -6.02 -0.31 4.66e-9 Resistin levels; LUSC cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.5 -0.46 4.07e-19 Schizophrenia; LUSC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg06481639 chr22:41940642 POLR3H 0.52 5.86 0.31 1.1e-8 Vitiligo; LUSC cis rs73200209 0.704 rs56258518 chr12:116596371 G/A cg01776926 chr12:116560359 MED13L -0.51 -6.13 -0.32 2.45e-9 Total body bone mineral density; LUSC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg05347473 chr6:146136440 FBXO30 -0.67 -11.71 -0.54 9.19e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs727505 0.954 rs58618031 chr7:124583896 T/C cg23710748 chr7:124431027 NA -0.38 -6.73 -0.35 7.42e-11 Lewy body disease; LUSC cis rs11608355 0.545 rs11066737 chr12:109904792 A/G cg05360138 chr12:110035743 NA -0.9 -11.66 -0.54 1.37e-26 Neuroticism; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg24846343 chr22:24311635 DDTL -0.68 -14.45 -0.62 4.37e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg13628971 chr7:2884303 GNA12 0.37 5.71 0.3 2.49e-8 Height; LUSC cis rs7180079 0.925 rs62024254 chr15:64461098 T/C cg08069370 chr15:64387884 SNX1 -0.54 -5.65 -0.3 3.37e-8 Monocyte count; LUSC cis rs9815354 0.812 rs73071358 chr3:41830487 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs7824557 0.628 rs11777746 chr8:11204755 T/C cg21775007 chr8:11205619 TDH 0.82 13.51 0.59 1.71e-33 Retinal vascular caliber; LUSC cis rs425277 0.917 rs262656 chr1:2088754 A/C cg24578937 chr1:2090814 PRKCZ 0.6 13.58 0.6 9.62e-34 Height; LUSC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.48 -6.72 -0.35 7.77e-11 Eosinophil percentage of white cells; LUSC cis rs6712932 1.000 rs6734358 chr2:105843732 A/C cg22878388 chr2:105853796 NA -0.33 -6.02 -0.31 4.68e-9 Type 2 diabetes; LUSC cis rs2290416 0.892 rs61652493 chr8:144669164 G/A cg14809332 chr8:144654887 C8orf73 0.54 6.51 0.34 2.78e-10 Attention deficit hyperactivity disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13028789 chr6:34856920 ANKS1A;TAF11 -0.39 -6.1 -0.32 2.88e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7582180 0.606 rs12618908 chr2:100947026 A/T cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg04727924 chr7:799746 HEATR2 0.57 6.04 0.31 4.18e-9 Cerebrospinal P-tau181p levels; LUSC cis rs6494488 0.500 rs72744763 chr15:65076652 C/T cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs9309473 1.000 rs1114380 chr2:73804708 A/G cg20560298 chr2:73613845 ALMS1 -0.45 -6.46 -0.33 3.6e-10 Metabolite levels; LUSC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.22 0.32 1.45e-9 Menopause (age at onset); LUSC cis rs1595825 0.891 rs73054867 chr2:198700417 C/G cg10547527 chr2:198650123 BOLL -0.51 -5.94 -0.31 7.2e-9 Ulcerative colitis; LUSC trans rs61931739 0.649 rs708139 chr12:33733265 C/A cg26384229 chr12:38710491 ALG10B 0.43 6.18 0.32 1.9e-9 Morning vs. evening chronotype; LUSC cis rs10504229 1.000 rs59275611 chr8:58195191 G/A cg11062466 chr8:58055876 NA 0.5 5.86 0.31 1.11e-8 Developmental language disorder (linguistic errors); LUSC cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg15423357 chr2:25149977 NA 0.44 8.98 0.44 1.96e-17 Body mass index; LUSC cis rs9463078 0.585 rs7754378 chr6:44863106 A/G cg25276700 chr6:44698697 NA 0.28 5.83 0.3 1.28e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg22753607 chr9:37120306 ZCCHC7 0.43 6.08 0.32 3.36e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.46 0.33 3.62e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7223966 1.000 rs16947014 chr17:61719032 C/T cg05941027 chr17:61774174 LIMD2 0.22 5.83 0.3 1.29e-8 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs35851103 0.507 rs6601649 chr8:11857317 A/G cg27411982 chr8:10470053 RP1L1 -0.42 -5.99 -0.31 5.52e-9 Neuroticism; LUSC trans rs76540505 1.000 rs3758722 chr11:45243543 A/T cg03253268 chr21:44592883 CRYAA 0.6 6.01 0.31 4.92e-9 Mononucleosis; LUSC trans rs61931739 0.929 rs1844524 chr12:34094709 A/T cg13010199 chr12:38710504 ALG10B -0.46 -7.29 -0.37 2.23e-12 Morning vs. evening chronotype; LUSC cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg06064525 chr11:970664 AP2A2 -0.35 -6.87 -0.35 3.12e-11 Alzheimer's disease (late onset); LUSC cis rs7568458 0.870 rs6719046 chr2:85757371 G/A cg23752985 chr2:85803571 VAMP8 0.33 7.06 0.36 9.48e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9911578 1.000 rs2270097 chr17:56572070 G/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.98 -0.31 5.74e-9 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg11764359 chr7:65958608 NA -0.54 -7.02 -0.36 1.23e-11 Aortic root size; LUSC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg06108461 chr20:60628389 TAF4 -0.94 -15.4 -0.64 8.59e-41 Body mass index; LUSC trans rs7618501 0.633 rs7621026 chr3:49975334 A/G cg21659725 chr3:3221576 CRBN 0.63 10.53 0.5 1.38e-22 Intelligence (multi-trait analysis); LUSC cis rs10208940 0.764 rs6546420 chr2:68799454 G/A cg12452813 chr2:68675892 NA 0.57 5.92 0.31 7.99e-9 Urate levels in lean individuals; LUSC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC cis rs7582180 0.614 rs10193204 chr2:101004540 A/G cg12002119 chr2:101014098 CHST10 -0.37 -6.17 -0.32 1.95e-9 Intelligence (multi-trait analysis); LUSC trans rs6502050 0.865 rs74480314 chr17:80117716 C/T cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg17971929 chr21:40555470 PSMG1 -0.53 -7.93 -0.4 3.22e-14 Menarche (age at onset); LUSC cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg01579765 chr21:45077557 HSF2BP 0.49 10.11 0.48 3.8e-21 Mean corpuscular volume; LUSC cis rs2629540 0.889 rs7476729 chr10:126428174 C/G cg08799069 chr10:126477246 METTL10 -0.68 -9.81 -0.47 4.03e-20 Cocaine dependence; LUSC cis rs11690935 0.686 rs10165126 chr2:172820315 C/T cg13550731 chr2:172543902 DYNC1I2 -0.69 -10.35 -0.49 6.07e-22 Schizophrenia; LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg03352830 chr11:487213 PTDSS2 0.72 8.65 0.43 2.24e-16 Body mass index; LUSC cis rs992157 0.932 rs56109829 chr2:219149740 G/A cg00012203 chr2:219082015 ARPC2 0.81 14.27 0.62 2.11e-36 Colorectal cancer; LUSC cis rs2658782 0.666 rs2925361 chr11:93098823 G/A cg15737290 chr11:93063684 CCDC67 0.63 7.54 0.38 4.52e-13 Pulmonary function decline; LUSC cis rs8027181 0.839 rs8024986 chr15:73024868 A/G cg25632853 chr15:73088954 NA -0.31 -6.35 -0.33 6.89e-10 Triglyceride levels; LUSC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg03676636 chr4:99064102 C4orf37 0.35 7.41 0.38 1.03e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs883565 0.502 rs11129810 chr3:38946064 C/T cg26331595 chr3:39149181 GORASP1;TTC21A 0.38 5.75 0.3 2.02e-8 Handedness; LUSC trans rs1728785 0.818 rs1814299 chr16:68581332 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.6 0.38 3.08e-13 Ulcerative colitis; LUSC trans rs11098499 0.863 rs3733525 chr4:120447048 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.55 0.34 2.17e-10 Corneal astigmatism; LUSC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg22920501 chr2:26401640 FAM59B -0.73 -10.27 -0.49 1.06e-21 Gut microbiome composition (summer); LUSC cis rs8177179 0.505 rs1405023 chr3:133481128 T/C cg01448562 chr3:133502909 NA 0.44 6.77 0.35 5.67e-11 Iron status biomarkers (transferrin levels); LUSC cis rs6495122 0.501 rs12101482 chr15:75344784 A/T cg14664628 chr15:75095509 CSK 0.42 6.07 0.32 3.49e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC trans rs11650494 0.516 rs13341862 chr17:47494203 A/G cg00927294 chr7:122526408 CADPS2 -0.67 -5.95 -0.31 6.88e-9 Prostate cancer; LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03576123 chr11:487126 PTDSS2 -0.95 -10.54 -0.5 1.29e-22 Body mass index; LUSC trans rs61931739 0.782 rs7969373 chr12:34249655 T/G cg26384229 chr12:38710491 ALG10B 0.55 8.74 0.43 1.16e-16 Morning vs. evening chronotype; LUSC cis rs3806843 0.966 rs10036519 chr5:140151701 C/T cg19875535 chr5:140030758 IK -0.47 -7.59 -0.38 3.12e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg08684580 chr7:98029266 BAIAP2L1 -0.41 -7.43 -0.38 9.13e-13 Prostate cancer (SNP x SNP interaction); LUSC trans rs6502050 0.699 rs9901808 chr17:80107814 C/T cg07393940 chr7:158741817 NA 0.36 6.42 0.33 4.57e-10 Life satisfaction; LUSC cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg13256891 chr4:100009986 ADH5 0.51 6.94 0.35 2.07e-11 Smoking initiation; LUSC cis rs13256369 0.802 rs35382339 chr8:8559255 G/A cg06671706 chr8:8559999 CLDN23 0.5 6.49 0.33 3.18e-10 Obesity-related traits; LUSC cis rs10949662 1.000 rs11765189 chr7:157535977 A/G cg05731713 chr7:157510257 PTPRN2 0.43 7.78 0.39 9.28e-14 Intelligence (multi-trait analysis); LUSC cis rs12824058 0.844 rs10744458 chr12:130805820 C/T cg24838063 chr12:130822603 PIWIL1 -0.63 -9.86 -0.47 2.66e-20 Menopause (age at onset); LUSC cis rs7577851 0.625 rs12620315 chr2:69529531 C/T cg10773587 chr2:69614142 GFPT1 0.55 6.29 0.33 9.69e-10 Parkinson's disease (age of onset); LUSC cis rs11809207 1.000 rs34587428 chr1:26522392 C/T cg00300879 chr1:26503847 CNKSR1 0.31 5.87 0.31 1.05e-8 Height; LUSC cis rs9309473 1.000 rs56154726 chr2:73721767 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -6.38 -0.33 5.81e-10 Metabolite levels; LUSC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg24531977 chr5:56204891 C5orf35 -1.05 -15.91 -0.66 7.99e-43 Initial pursuit acceleration; LUSC cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg03146154 chr1:46216737 IPP -0.49 -6.79 -0.35 5.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs765787 0.530 rs1648285 chr15:45517505 C/G cg25801113 chr15:45476975 SHF 0.33 6.78 0.35 5.39e-11 Uric acid levels; LUSC cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.5 7.41 0.38 1.02e-12 Personality dimensions; LUSC cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg08999081 chr20:33150536 PIGU 0.53 10.17 0.49 2.45e-21 Coronary artery disease; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg07507251 chr3:52567010 NT5DC2 0.32 6.25 0.32 1.28e-9 Intelligence (multi-trait analysis); LUSC cis rs4654899 0.865 rs72973154 chr1:21459125 G/T cg01072550 chr1:21505969 NA -0.53 -7.93 -0.4 3.23e-14 Superior frontal gyrus grey matter volume; LUSC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg25456477 chr12:86230367 RASSF9 -0.34 -6.13 -0.32 2.42e-9 Major depressive disorder; LUSC cis rs11098499 0.739 rs4833612 chr4:120147596 A/C cg24375607 chr4:120327624 NA -0.69 -10.9 -0.51 6.88e-24 Corneal astigmatism; LUSC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg18827107 chr12:86230957 RASSF9 -0.5 -7.48 -0.38 6.66e-13 Major depressive disorder; LUSC cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Bone mineral density; LUSC cis rs10782582 0.522 rs12125933 chr1:76130920 C/T cg03433033 chr1:76189801 ACADM -0.44 -6.56 -0.34 2.02e-10 Daytime sleep phenotypes; LUSC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg13206674 chr6:150067644 NUP43 0.56 8.62 0.43 2.72e-16 Lung cancer; LUSC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg08219700 chr8:58056026 NA 0.64 8.51 0.42 5.97e-16 Developmental language disorder (linguistic errors); LUSC cis rs6543140 0.964 rs1523206 chr2:103070175 A/T cg09003973 chr2:102972529 NA 0.54 6.87 0.35 3.08e-11 Blood protein levels; LUSC trans rs11098499 0.708 rs11732686 chr4:120252330 C/A cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs6456156 0.586 rs12528323 chr6:167461645 A/G cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09911399 chr19:49999601 RPS11;SNORD35B -0.45 -6.67 -0.34 1.09e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21659725 chr3:3221576 CRBN -0.9 -18.4 -0.71 1.05e-52 Intelligence (multi-trait analysis); LUSC cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg22782873 chr19:19639568 YJEFN3 -0.48 -5.71 -0.3 2.43e-8 Bipolar disorder; LUSC cis rs9341808 0.644 rs62408577 chr6:80942024 T/A cg08355045 chr6:80787529 NA -0.42 -7.13 -0.36 6.17e-12 Sitting height ratio; LUSC cis rs9660992 1.000 rs9660992 chr1:205249450 A/G cg21643547 chr1:205240462 TMCC2 -0.47 -9.08 -0.44 9.58e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6546550 0.901 rs6750488 chr2:70146125 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.26 -0.37 2.67e-12 Prevalent atrial fibrillation; LUSC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg13206674 chr6:150067644 NUP43 0.6 9.66 0.47 1.21e-19 Lung cancer; LUSC cis rs6542838 0.698 rs6732017 chr2:99434381 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.46 -6.16 -0.32 2.08e-9 Fear of minor pain; LUSC cis rs131777 0.575 rs131760 chr22:51011936 T/C cg25309564 chr22:51001381 C22orf41 0.44 6.21 0.32 1.54e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg20243544 chr17:37824526 PNMT 0.51 7.39 0.38 1.15e-12 Asthma; LUSC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.61e-8 Diabetic kidney disease; LUSC cis rs34779708 0.931 rs11010132 chr10:35517265 C/G cg03585969 chr10:35415529 CREM 0.61 9.01 0.44 1.64e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg08677398 chr8:58056175 NA 0.52 6.32 0.33 8.27e-10 Developmental language disorder (linguistic errors); LUSC cis rs76662990 0.570 rs10070279 chr5:73898568 A/G cg01264639 chr5:73839484 NA 0.55 5.78 0.3 1.72e-8 Residual cognition; LUSC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs12908161 0.959 rs1051168 chr15:85200520 G/T cg17173187 chr15:85201210 NMB 0.5 9.42 0.46 7.89e-19 Schizophrenia; LUSC cis rs7296418 0.961 rs949143 chr12:123595163 G/A cg05973401 chr12:123451056 ABCB9 0.63 9.19 0.45 4.44e-18 Platelet count; LUSC cis rs9486719 1.000 rs34236778 chr6:96884556 C/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC trans rs35110281 0.743 rs230640 chr21:44914815 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.56 -9.11 -0.45 7.53e-18 Mean corpuscular volume; LUSC cis rs739401 0.869 rs395188 chr11:3072631 A/G cg08508325 chr11:3079039 CARS 0.47 11.16 0.52 8.37e-25 Longevity; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25061763 chr12:62860430 MON2 0.4 6.07 0.32 3.56e-9 Mosquito bite size; LUSC cis rs6546550 0.901 rs6729760 chr2:70161032 C/T cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.19e-12 Prevalent atrial fibrillation; LUSC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg04234412 chr22:24373322 LOC391322 -0.92 -16.14 -0.66 9.72e-44 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.11 0.45 7.84e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6499755 0.901 rs4784522 chr16:55348749 C/T cg02859129 chr16:55357253 IRX6 0.37 6.27 0.32 1.08e-9 Hypospadias; LUSC cis rs9325144 0.600 rs10748442 chr12:38732939 A/T cg13010199 chr12:38710504 ALG10B 0.47 7.3 0.37 2.17e-12 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs11615231 chr12:34413330 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.68 0.65 6.55e-42 Morning vs. evening chronotype; LUSC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.75 -0.3 2e-8 Reticulocyte fraction of red cells; LUSC cis rs2742417 1.000 rs1609554 chr3:45735192 A/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.38 -0.37 1.24e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.88 -0.31 9.9e-9 Testicular germ cell tumor; LUSC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg18876405 chr7:65276391 NA 0.6 9.71 0.47 8.76e-20 Aortic root size; LUSC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg12311346 chr5:56204834 C5orf35 0.83 13.27 0.59 1.46e-32 Initial pursuit acceleration; LUSC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg06134567 chr22:46658398 PKDREJ -0.53 -6.0 -0.31 5.15e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg06484146 chr7:12443880 VWDE -0.69 -7.28 -0.37 2.41e-12 Coronary artery disease; LUSC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -8.27 -0.41 3.23e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4975709 1.000 rs4975709 chr5:1877280 A/C cg15595755 chr5:1867978 NA 0.35 5.76 0.3 1.91e-8 Cardiovascular disease risk factors; LUSC cis rs7100689 0.646 rs7098045 chr10:82123856 G/C cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs909674 0.515 rs9611170 chr22:39784845 G/C cg05872129 chr22:39784769 NA -0.63 -11.86 -0.54 2.61e-27 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg16482183 chr6:26056742 HIST1H1C 0.57 8.24 0.41 4.04e-15 Height; LUSC cis rs61931739 0.929 rs1844524 chr12:34094709 A/T cg06521331 chr12:34319734 NA 0.38 6.41 0.33 4.83e-10 Morning vs. evening chronotype; LUSC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg24585782 chr17:78113791 EIF4A3 -0.54 -8.12 -0.41 9.39e-15 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.68 -0.57 2.41e-30 Chronic sinus infection; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg27368511 chr5:159826822 C5orf54 0.46 6.77 0.35 5.71e-11 Risky sexual behaviors in alcohol dependence; LUSC cis rs6121246 0.580 rs6121016 chr20:30245239 C/T cg13852791 chr20:30311386 BCL2L1 0.87 11.09 0.52 1.53e-24 Mean corpuscular hemoglobin; LUSC cis rs6982240 1.000 rs6982240 chr8:142257378 A/T cg27411547 chr8:142287226 NA -0.35 -6.14 -0.32 2.33e-9 Tonsillectomy; LUSC cis rs9394159 0.583 rs4713650 chr6:33616828 C/T cg14003231 chr6:33640908 ITPR3 -0.44 -8.83 -0.44 5.87e-17 Graves' disease; LUSC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg18876405 chr7:65276391 NA 0.55 8.79 0.43 8.1e-17 Aortic root size; LUSC cis rs55882075 0.936 rs34646062 chr5:179186318 A/G cg14593053 chr5:179126677 CANX -0.4 -6.65 -0.34 1.17e-10 Monocyte percentage of white cells; LUSC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg04166393 chr7:2884313 GNA12 0.48 6.18 0.32 1.9e-9 Height; LUSC cis rs1982963 0.572 rs61971551 chr14:52479975 C/G cg10843707 chr14:52510701 NID2 0.42 5.87 0.31 1.04e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7618501 1.000 rs34614773 chr3:49753003 T/G cg07274523 chr3:49395745 GPX1 0.35 5.65 0.3 3.47e-8 Intelligence (multi-trait analysis); LUSC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg22875332 chr1:76189707 ACADM 0.81 11.76 0.54 6.2e-27 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.66 -0.57 2.83e-30 Platelet count; LUSC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg24110177 chr3:50126178 RBM5 0.54 8.88 0.44 4.34e-17 Intelligence (multi-trait analysis); LUSC cis rs11229555 1.000 rs8373 chr11:58378424 A/G cg15696309 chr11:58395628 NA -0.7 -9.26 -0.45 2.49e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg15704280 chr7:45808275 SEPT13 -1.12 -25.06 -0.81 9.82e-79 Height; LUSC cis rs8067354 0.830 rs2453913 chr17:57860150 G/T cg02344993 chr17:57696989 CLTC 0.37 5.69 0.3 2.78e-8 Hemoglobin concentration; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg18110333 chr6:292329 DUSP22 -0.52 -7.68 -0.39 1.76e-13 Menopause (age at onset); LUSC cis rs7705502 1.000 rs72812852 chr5:173379347 G/T cg18693985 chr5:173351052 CPEB4 -0.4 -6.17 -0.32 2.01e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7089973 0.604 rs55759483 chr10:116573423 T/C cg23260525 chr10:116636907 FAM160B1 0.47 9.82 0.47 3.75e-20 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9443189 0.526 rs9359132 chr6:76289553 G/A cg01950844 chr6:76311363 SENP6 0.7 6.97 0.36 1.74e-11 Prostate cancer; LUSC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.5 7.79 0.39 8.3e-14 Parkinson's disease; LUSC cis rs12701220 0.553 rs34062359 chr7:1139076 C/T cg00990874 chr7:1149470 C7orf50 -0.57 -7.02 -0.36 1.21e-11 Bronchopulmonary dysplasia; LUSC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg13628971 chr7:2884303 GNA12 0.46 6.58 0.34 1.8e-10 Height; LUSC cis rs921968 0.541 rs3755042 chr2:219317248 T/C cg02176678 chr2:219576539 TTLL4 -0.74 -14.22 -0.61 3.41e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg18876405 chr7:65276391 NA 0.58 9.4 0.46 9.19e-19 Aortic root size; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg12143784 chr7:64541923 NA 0.41 6.46 0.33 3.61e-10 Calcium levels; LUSC cis rs2839186 0.867 rs13050387 chr21:47701423 C/T cg12379764 chr21:47803548 PCNT -0.42 -5.96 -0.31 6.38e-9 Testicular germ cell tumor; LUSC cis rs7904368 0.951 rs7074647 chr10:16855455 T/C cg14835575 chr10:16859367 RSU1 0.66 8.75 0.43 1.09e-16 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs11031096 0.711 rs4910891 chr11:4153408 A/G cg08557956 chr11:4115526 RRM1 -0.42 -5.72 -0.3 2.34e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9527 0.521 rs12259163 chr10:104961477 A/G cg04362960 chr10:104952993 NT5C2 0.63 9.99 0.48 9.53e-21 Arsenic metabolism; LUSC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg18240062 chr17:79603768 NPLOC4 0.63 11.22 0.52 5.37e-25 Eye color traits; LUSC cis rs7647973 0.626 rs1078341 chr3:49685592 A/G cg13072238 chr3:49761600 GMPPB -0.71 -9.47 -0.46 5.11e-19 Menarche (age at onset); LUSC cis rs7172677 0.732 rs1867147 chr15:75363357 C/T cg14664628 chr15:75095509 CSK 0.49 6.15 0.32 2.22e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs911119 0.908 rs6048949 chr20:23603199 C/T cg16589663 chr20:23618590 CST3 0.57 6.82 0.35 4.18e-11 Chronic kidney disease; LUSC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg21548813 chr6:291882 DUSP22 -0.48 -6.95 -0.36 1.91e-11 Menopause (age at onset); LUSC cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg03146154 chr1:46216737 IPP -0.57 -8.23 -0.41 4.16e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs713587 1.000 rs713587 chr2:25158281 C/T cg01884057 chr2:25150051 NA 0.47 11.13 0.52 1.11e-24 Body mass index in non-asthmatics; LUSC cis rs3126085 0.867 rs11204948 chr1:152218473 A/G cg03465714 chr1:152285911 FLG -0.42 -5.71 -0.3 2.47e-8 Atopic dermatitis; LUSC cis rs9549260 0.534 rs4943809 chr13:41297404 T/A cg21288729 chr13:41239152 FOXO1 0.58 6.65 0.34 1.18e-10 Red blood cell count; LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg08859206 chr1:53392774 SCP2 0.56 9.82 0.47 3.69e-20 Monocyte count; LUSC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.77 -0.43 9.44e-17 Axial length; LUSC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg25019033 chr10:957182 NA -0.52 -7.06 -0.36 9.93e-12 Eosinophil percentage of granulocytes; LUSC trans rs12310956 0.532 rs7955514 chr12:33978737 G/A cg26384229 chr12:38710491 ALG10B 0.74 11.71 0.54 8.93e-27 Morning vs. evening chronotype; LUSC cis rs738322 0.967 rs133024 chr22:38574066 C/T cg17652424 chr22:38574118 PLA2G6 0.3 6.56 0.34 2.06e-10 Cutaneous nevi; LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC trans rs59551326 0.688 rs2829660 chr21:26622137 A/G cg19883748 chr14:71905595 NA -0.43 -6.18 -0.32 1.83e-9 Alcohol dependence; LUSC cis rs9527 0.615 rs7073295 chr10:104672233 A/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.66 -0.34 1.11e-10 Arsenic metabolism; LUSC cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg23711669 chr6:146136114 FBXO30 -0.91 -17.88 -0.7 1.27e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs912330 0.825 rs7317938 chr13:99234361 C/T cg07423050 chr13:99094983 FARP1 -0.39 -7.36 -0.37 1.46e-12 Alzheimer's disease; LUSC cis rs1788820 0.917 rs1788760 chr18:21137442 A/G cg14672496 chr18:21087552 C18orf8 0.43 6.94 0.35 2.06e-11 Body mass index; LUSC cis rs6542838 0.641 rs4851176 chr2:99534859 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.48 -0.38 6.82e-13 Fear of minor pain; LUSC cis rs17490626 0.568 rs12413529 chr10:71211644 G/T cg12610070 chr10:71211762 TSPAN15 -0.49 -9.43 -0.46 7e-19 Thrombosis; LUSC cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg06092702 chr1:163392909 NA -0.43 -7.22 -0.37 3.47e-12 Motion sickness; LUSC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg02580895 chr19:2754563 NA 0.47 7.09 0.36 8.05e-12 Total cholesterol levels; LUSC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.39 0.53 1.32e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs17818399 0.547 rs12997164 chr2:46758746 A/C cg02822958 chr2:46747628 ATP6V1E2 0.4 6.04 0.31 4.15e-9 Height; LUSC cis rs2346177 0.777 rs7587138 chr2:46657089 A/G cg26688816 chr2:46740690 ATP6V1E2 0.54 8.38 0.42 1.46e-15 HDL cholesterol; LUSC cis rs12410462 0.581 rs112572966 chr1:227553905 C/T cg10327440 chr1:227177885 CDC42BPA -0.58 -5.65 -0.3 3.51e-8 Major depressive disorder; LUSC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg22875332 chr1:76189707 ACADM -0.85 -13.95 -0.61 3.48e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg22437258 chr11:111473054 SIK2 0.51 7.08 0.36 8.78e-12 Primary sclerosing cholangitis; LUSC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg13114125 chr14:105738426 BRF1 -0.93 -16.06 -0.66 2.05e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs7178572 0.568 rs12905951 chr15:77649431 G/A cg22256960 chr15:77711686 NA -0.51 -8.12 -0.41 9.12e-15 Type 2 diabetes; LUSC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.01 -0.31 4.79e-9 Total body bone mineral density; LUSC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg18876405 chr7:65276391 NA 0.75 13.25 0.59 1.76e-32 Aortic root size; LUSC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg13902645 chr11:5959945 NA 0.61 8.65 0.43 2.25e-16 DNA methylation (variation); LUSC cis rs1018836 0.923 rs7007102 chr8:91629730 T/A cg16814680 chr8:91681699 NA -0.76 -12.7 -0.57 2.04e-30 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs708547 0.871 rs2687238 chr4:57880474 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.54 -0.34 2.27e-10 Response to bleomycin (chromatid breaks); LUSC cis rs7980687 0.574 rs10744149 chr12:123708490 T/A cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Height;Educational attainment;Head circumference (infant); LUSC trans rs12517041 1.000 rs10520890 chr5:23290143 C/T cg09395612 chr16:86018936 NA 0.4 6.13 0.32 2.49e-9 Calcium levels; LUSC cis rs7598759 0.679 rs6740843 chr2:232332139 A/C cg19187155 chr2:232395269 NMUR1 0.49 7.28 0.37 2.37e-12 Noise-induced hearing loss; LUSC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg04234412 chr22:24373322 LOC391322 -0.86 -14.05 -0.61 1.45e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7927771 0.524 rs1563820 chr11:47833398 A/T cg20307385 chr11:47447363 PSMC3 -0.45 -6.69 -0.34 9.64e-11 Subjective well-being; LUSC cis rs4363385 0.818 rs3820141 chr1:153004778 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.46e-8 Inflammatory skin disease; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg24060327 chr5:131705240 SLC22A5 -0.39 -6.48 -0.33 3.38e-10 Blood metabolite levels; LUSC cis rs7617773 0.780 rs6442111 chr3:48312060 G/C cg11946769 chr3:48343235 NME6 0.88 14.28 0.62 1.99e-36 Coronary artery disease; LUSC cis rs7241530 0.595 rs12957925 chr18:75900192 G/A cg14642773 chr18:75888474 NA 0.38 5.72 0.3 2.43e-8 Educational attainment (years of education); LUSC cis rs7582720 1.000 rs77230711 chr2:203805552 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg18404041 chr3:52824283 ITIH1 -0.58 -9.62 -0.47 1.75e-19 Schizophrenia; LUSC cis rs1577917 1.000 rs12213740 chr6:86656733 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.33 -0.33 7.84e-10 Response to antipsychotic treatment; LUSC trans rs35110281 0.607 rs4819212 chr21:44977455 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 10.46 0.5 2.41e-22 Mean corpuscular volume; LUSC cis rs7746199 0.736 rs13193480 chr6:27702561 A/G cg26958806 chr6:27640298 NA 0.74 6.04 0.31 4.02e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs7927592 0.513 rs689075 chr11:68194432 A/C cg16797656 chr11:68205561 LRP5 0.47 8.43 0.42 1.07e-15 Total body bone mineral density; LUSC cis rs929354 0.709 rs1182363 chr7:157019151 A/G cg17757837 chr7:157058334 UBE3C -0.82 -13.3 -0.59 1.14e-32 Body mass index; LUSC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg07701084 chr6:150067640 NUP43 0.57 8.96 0.44 2.36e-17 Lung cancer; LUSC cis rs4478037 1.000 rs4074418 chr3:33161165 G/T cg19404215 chr3:33155277 CRTAP 0.96 9.76 0.47 5.72e-20 Major depressive disorder; LUSC cis rs6163 0.588 rs67506723 chr10:104509064 G/T cg05855489 chr10:104503620 C10orf26 0.92 18.24 0.71 4.68e-52 Waist circumference;Hip circumference; LUSC cis rs73200209 0.744 rs61354255 chr12:116444609 A/T cg01776926 chr12:116560359 MED13L -0.51 -5.9 -0.31 8.97e-9 Total body bone mineral density; LUSC cis rs238295 0.805 rs6053527 chr20:5582457 G/T cg15842884 chr20:5591925 RP5-1022P6.2 -0.44 -5.98 -0.31 5.89e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs16866061 1.000 rs72974263 chr2:225447371 C/T cg12698349 chr2:225449008 CUL3 0.85 13.9 0.61 5.46e-35 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg04518342 chr5:131593106 PDLIM4 0.45 8.24 0.41 3.96e-15 Breast cancer; LUSC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.86 -0.35 3.42e-11 Intelligence (multi-trait analysis); LUSC cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.49 -5.67 -0.3 3.13e-8 Schizophrenia; LUSC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg12463550 chr7:65579703 CRCP 0.5 7.18 0.37 4.47e-12 Aortic root size; LUSC cis rs796364 0.951 rs7586320 chr2:201068209 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 5.71 0.3 2.56e-8 Schizophrenia; LUSC cis rs7937682 0.921 rs1944119 chr11:111436387 A/G cg11344533 chr11:111475393 SIK2 0.44 5.77 0.3 1.8e-8 Primary sclerosing cholangitis; LUSC cis rs4803468 1.000 rs10413735 chr19:41921071 C/T cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.42 5.74 0.3 2.13e-8 Height; LUSC trans rs12188164 0.965 rs11744539 chr5:451425 C/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg16447950 chr5:562315 NA -0.54 -6.69 -0.34 9.21e-11 Obesity-related traits; LUSC cis rs735539 1.000 rs2290143 chr13:21280363 A/G cg27499820 chr13:21296301 IL17D -0.3 -5.72 -0.3 2.34e-8 Dental caries; LUSC cis rs12594515 1.000 rs6493170 chr15:45987019 G/A cg06207120 chr15:45996521 NA 0.4 6.23 0.32 1.38e-9 Waist circumference;Weight; LUSC cis rs2204008 0.542 rs34770471 chr12:38009613 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.9 0.66 8.5e-43 Bladder cancer; LUSC cis rs11864453 0.826 rs12325142 chr16:72138112 G/T cg01557791 chr16:72042693 DHODH -0.51 -7.33 -0.37 1.74e-12 Fibrinogen levels; LUSC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg09455208 chr3:40491958 NA -0.55 -9.93 -0.48 1.51e-20 Renal cell carcinoma; LUSC cis rs2274273 0.905 rs2075601 chr14:55609234 C/T cg04306507 chr14:55594613 LGALS3 0.58 13.35 0.59 6.92e-33 Protein biomarker; LUSC cis rs3892630 0.619 rs61062732 chr19:33304717 T/C cg22980127 chr19:33182716 NUDT19 0.9 13.02 0.58 1.21e-31 Red blood cell traits; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07786668 chr16:73092391 ZFHX3 0.38 6.8 0.35 4.9e-11 Triglycerides; LUSC cis rs9611565 0.879 rs4820437 chr22:41761290 T/C cg03806693 chr22:41940476 POLR3H -0.78 -11.2 -0.52 6.07e-25 Vitiligo; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.49 0.46 4.39e-19 Bipolar disorder; LUSC cis rs210143 1 rs210143 chr6:33546930 T/C cg07679836 chr6:33548423 BAK1 0.51 8.12 0.41 9.22e-15 Neutrophil percentage of granulocytes;B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy);Chronic lymphocytic leukemia; LUSC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.34 -0.37 1.59e-12 Menarche (age at onset); LUSC cis rs9677476 1.000 rs6704770 chr2:232109816 T/G cg07929768 chr2:232055508 NA 0.32 6.06 0.31 3.67e-9 Food antigen IgG levels; LUSC cis rs12618769 0.793 rs6741558 chr2:99258487 G/T cg10123293 chr2:99228465 UNC50 0.43 5.99 0.31 5.36e-9 Bipolar disorder; LUSC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg08392591 chr16:89556376 ANKRD11 0.38 5.78 0.3 1.68e-8 Multiple myeloma (IgH translocation); LUSC cis rs10979 0.964 rs35205240 chr6:143898676 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -11.79 -0.54 4.66e-27 Hypospadias; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06851336 chr10:104678166 CNNM2 -0.41 -5.99 -0.31 5.45e-9 Electrocardiographic conduction measures; LUSC cis rs870825 0.932 rs13136635 chr4:185574807 C/T cg04058563 chr4:185651563 MLF1IP -0.83 -11.2 -0.52 6.41e-25 Blood protein levels; LUSC cis rs16854884 0.770 rs1530477 chr3:143819506 A/G cg06585982 chr3:143692056 C3orf58 -0.45 -6.73 -0.35 7.58e-11 Economic and political preferences (feminism/equality); LUSC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg27170947 chr2:26402098 FAM59B -0.62 -9.28 -0.45 2.25e-18 Gut microbiome composition (summer); LUSC cis rs6754311 0.773 rs309178 chr2:136611624 C/T cg25344623 chr2:136566232 LCT 0.37 5.68 0.3 2.96e-8 Mosquito bite size; LUSC cis rs7072216 0.727 rs10748728 chr10:100171198 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs546131 0.928 rs516228 chr11:34838823 C/T cg11058730 chr11:34937778 PDHX;APIP 0.46 6.3 0.33 9.18e-10 Lung disease severity in cystic fibrosis; LUSC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg08439880 chr3:133502540 NA 0.36 6.35 0.33 7.13e-10 Iron status biomarkers; LUSC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg18306943 chr3:40428807 ENTPD3 0.38 5.95 0.31 6.88e-9 Renal cell carcinoma; LUSC cis rs983392 0.868 rs11605427 chr11:59928672 G/C cg24026212 chr11:59952134 MS4A6A -0.35 -5.83 -0.3 1.33e-8 Alzheimer's disease (late onset); LUSC trans rs853679 1.000 rs1778508 chr6:28229881 C/T cg01620082 chr3:125678407 NA 0.51 6.07 0.32 3.41e-9 Depression; LUSC cis rs10886558 0.674 rs10788015 chr10:121781396 C/T cg02041677 chr10:121771263 NA -0.35 -6.48 -0.33 3.21e-10 Shingles; LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg16325326 chr1:53192061 ZYG11B 0.88 16.16 0.66 7.99e-44 Monocyte count; LUSC cis rs9326248 0.581 rs10892076 chr11:116988936 G/A cg10130564 chr11:117069849 TAGLN 0.33 6.28 0.33 1.03e-9 Blood protein levels; LUSC cis rs1577917 0.958 rs10944137 chr6:86454314 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -9.05 -0.44 1.23e-17 Response to antipsychotic treatment; LUSC cis rs9527 0.590 rs1541213 chr10:104885330 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg06634786 chr22:41940651 POLR3H -0.53 -6.19 -0.32 1.81e-9 Vitiligo; LUSC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg01065977 chr19:18549689 ISYNA1 -0.23 -5.74 -0.3 2.18e-8 Breast cancer; LUSC cis rs2688608 0.901 rs2664282 chr10:75620757 T/C cg23231163 chr10:75533350 FUT11 -0.41 -6.54 -0.34 2.27e-10 Inflammatory bowel disease; LUSC cis rs981844 0.712 rs1456397 chr4:154744554 C/G cg14289246 chr4:154710475 SFRP2 0.45 6.23 0.32 1.44e-9 Response to statins (LDL cholesterol change); LUSC cis rs2224391 0.628 rs2753230 chr6:5248538 C/G cg09085698 chr6:5261316 LYRM4;FARS2 0.47 6.48 0.33 3.34e-10 Height; LUSC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg00310523 chr12:86230176 RASSF9 -0.44 -8.11 -0.41 9.88e-15 Major depressive disorder; LUSC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg15225532 chr3:44803084 KIF15;KIAA1143 0.5 7.91 0.4 3.78e-14 Depressive symptoms; LUSC cis rs9467773 1.000 rs2255070 chr6:26501777 C/G cg09904177 chr6:26538194 HMGN4 0.72 13.1 0.58 6.25e-32 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg05347473 chr6:146136440 FBXO30 0.55 9.26 0.45 2.5e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs12594515 1.000 rs6493175 chr15:45989898 T/C cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs12348691 0.503 rs7848950 chr9:100612774 T/C cg13688889 chr9:100608707 NA -0.81 -12.63 -0.57 3.79e-30 Alopecia areata; LUSC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg13607699 chr17:42295918 UBTF -0.48 -7.24 -0.37 3.15e-12 Total body bone mineral density; LUSC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg14019146 chr3:50243930 SLC38A3 -0.32 -6.96 -0.36 1.82e-11 Intelligence (multi-trait analysis); LUSC cis rs796364 0.589 rs55700082 chr2:201135669 G/A cg23649088 chr2:200775458 C2orf69 -0.57 -7.85 -0.39 5.7e-14 Schizophrenia; LUSC cis rs778371 0.659 rs2289911 chr2:233704252 A/G cg08000102 chr2:233561755 GIGYF2 -0.78 -12.26 -0.56 8.89e-29 Schizophrenia; LUSC cis rs1949733 1.000 rs1916326 chr4:8500023 G/A cg13073564 chr4:8508604 NA 0.48 8.96 0.44 2.37e-17 Response to antineoplastic agents; LUSC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg22467129 chr15:76604101 ETFA 0.43 6.89 0.35 2.8e-11 Blood metabolite levels; LUSC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg03929089 chr4:120376271 NA -0.94 -16.47 -0.67 5.04e-45 Height; LUSC cis rs11264213 0.901 rs72661625 chr1:36401003 T/C cg27506609 chr1:36549197 TEKT2 0.7 8.04 0.4 1.62e-14 Schizophrenia; LUSC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg11812906 chr14:75593930 NEK9 0.66 11.36 0.53 1.7e-25 Height; LUSC cis rs41271473 0.950 rs72751907 chr1:228867648 C/T cg16512390 chr1:228756714 NA 0.53 6.22 0.32 1.5e-9 Chronic lymphocytic leukemia; LUSC cis rs9325144 0.600 rs1825807 chr12:38737007 T/C cg13010199 chr12:38710504 ALG10B 0.47 7.39 0.37 1.17e-12 Morning vs. evening chronotype; LUSC cis rs11971779 0.680 rs6467848 chr7:139080205 T/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 8.07 0.4 1.27e-14 Personality dimensions; LUSC cis rs7584330 0.666 rs72620819 chr2:238354982 C/T cg14458575 chr2:238380390 NA 0.85 14.52 0.62 2.26e-37 Prostate cancer; LUSC cis rs2835872 0.758 rs1787394 chr21:39036176 C/A cg20424643 chr21:39039972 KCNJ6 -0.44 -7.42 -0.38 9.81e-13 Electroencephalographic traits in alcoholism; LUSC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -6.16 -0.32 2.11e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs79149102 0.579 rs74023908 chr15:75310710 T/C cg17294928 chr15:75287854 SCAMP5 -0.72 -6.65 -0.34 1.2e-10 Lung cancer; LUSC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC cis rs7020830 0.931 rs7034554 chr9:37081301 A/G cg14294708 chr9:37120828 ZCCHC7 1.1 24.6 0.8 5.88e-77 Schizophrenia; LUSC cis rs11229555 0.645 rs7929868 chr11:58209418 C/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1443512 0.812 rs1975472 chr12:54337083 A/G cg25024717 chr12:54324583 NA -0.38 -6.32 -0.33 8.32e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs6967385 0.900 rs10278941 chr7:12364646 G/C cg06484146 chr7:12443880 VWDE 0.42 6.21 0.32 1.56e-9 Response to taxane treatment (placlitaxel); LUSC cis rs12410462 0.581 rs77430808 chr1:227540880 C/T cg23173402 chr1:227635558 NA 0.55 6.46 0.33 3.76e-10 Major depressive disorder; LUSC cis rs2635047 0.901 rs2684837 chr18:44749884 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.89 0.35 2.78e-11 Educational attainment; LUSC cis rs9653442 0.527 rs4851258 chr2:100780830 T/C cg22139774 chr2:100720529 AFF3 -0.41 -7.12 -0.36 6.51e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg15557168 chr22:42548783 NA 0.47 7.33 0.37 1.76e-12 Schizophrenia; LUSC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg13531842 chr10:38383804 ZNF37A -0.45 -6.91 -0.35 2.53e-11 Extrinsic epigenetic age acceleration; LUSC cis rs1113500 0.897 rs55980437 chr1:108639498 G/A cg06207961 chr1:108661230 NA 0.41 7.61 0.38 2.76e-13 Growth-regulated protein alpha levels; LUSC cis rs826838 0.967 rs826876 chr12:39123843 T/C cg26384229 chr12:38710491 ALG10B -0.84 -15.73 -0.65 4.07e-42 Heart rate; LUSC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg20203395 chr5:56204925 C5orf35 0.57 8.13 0.41 8.57e-15 Initial pursuit acceleration; LUSC cis rs997295 0.675 rs12912974 chr15:67974379 G/C cg08079166 chr15:68083412 MAP2K5 -0.33 -6.56 -0.34 2.11e-10 Motion sickness; LUSC trans rs11098499 0.580 rs12509234 chr4:120319434 T/C cg25214090 chr10:38739885 LOC399744 0.54 7.9 0.4 4.18e-14 Corneal astigmatism; LUSC cis rs1595825 0.891 rs7595819 chr2:198543156 A/C cg00982548 chr2:198649783 BOLL 0.57 7.09 0.36 8.19e-12 Ulcerative colitis; LUSC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg06484146 chr7:12443880 VWDE -0.7 -7.51 -0.38 5.55e-13 Coronary artery disease; LUSC cis rs4132509 0.744 rs12124113 chr1:243904366 A/G cg21452805 chr1:244014465 NA 0.59 6.63 0.34 1.36e-10 RR interval (heart rate); LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg08088566 chr11:430123 ANO9 0.67 7.4 0.38 1.08e-12 Body mass index; LUSC cis rs477692 1.000 rs485576 chr10:131425496 G/C cg11019008 chr10:131425282 MGMT 0.42 6.31 0.33 8.97e-10 Response to temozolomide; LUSC trans rs7567288 0.636 rs12998999 chr2:134466938 T/G cg12381416 chr3:14359266 NA 0.53 5.99 0.31 5.3e-9 Height; LUSC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg20933634 chr6:27740509 NA 0.42 5.92 0.31 8.17e-9 Parkinson's disease; LUSC cis rs4144027 0.791 rs11160770 chr14:104362291 A/C cg12183467 chr14:104352244 NA 0.29 5.78 0.3 1.73e-8 Blood metabolite levels; LUSC cis rs600231 0.571 rs10896000 chr11:65218018 A/G cg21890820 chr11:65308645 LTBP3 0.48 6.99 0.36 1.51e-11 Bone mineral density; LUSC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11644478 chr21:40555479 PSMG1 -0.82 -14.89 -0.63 8.52e-39 Cognitive function; LUSC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.48 -0.33 3.34e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg17366294 chr4:99064904 C4orf37 0.61 10.83 0.51 1.3e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9322817 0.691 rs2400071 chr6:105344075 C/T cg02098413 chr6:105308735 HACE1 0.28 5.96 0.31 6.43e-9 Thyroid stimulating hormone; LUSC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC cis rs11785400 0.890 rs13279182 chr8:143720544 A/G cg10596483 chr8:143751796 JRK 0.59 8.83 0.44 6.04e-17 Schizophrenia; LUSC cis rs28595532 0.920 rs17258830 chr4:119725543 A/T cg21605333 chr4:119757512 SEC24D -1.34 -10.81 -0.51 1.49e-23 Cannabis dependence symptom count; LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg03461704 chr1:205818484 PM20D1 0.39 6.42 0.33 4.66e-10 Menarche (age at onset); LUSC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.67 -11.49 -0.53 5.46e-26 IgG glycosylation; LUSC trans rs4942242 0.663 rs7319346 chr13:44218201 T/C cg19169023 chr15:41853346 TYRO3 -0.57 -8.73 -0.43 1.23e-16 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs2562456 0.754 rs11673320 chr19:21507603 G/A cg00806126 chr19:22604979 ZNF98 -0.42 -5.99 -0.31 5.56e-9 Pain; LUSC cis rs9457247 0.871 rs1811121 chr6:167403539 T/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 7.41 0.38 1.05e-12 Colorectal cancer; LUSC cis rs7258465 1.000 rs10164319 chr19:18569833 G/A cg06462663 chr19:18546047 ISYNA1 0.47 7.81 0.39 7.61e-14 Breast cancer; LUSC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.61e-8 Diabetic kidney disease; LUSC cis rs870825 0.616 rs6552807 chr4:185640531 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.27 0.59 1.47e-32 Blood protein levels; LUSC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg06022373 chr22:39101656 GTPBP1 0.81 12.65 0.57 3.15e-30 Menopause (age at onset); LUSC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 7.17 0.37 4.86e-12 Platelet count; LUSC cis rs2486288 0.656 rs9921025 chr15:45546602 G/A cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.76 -0.51 2.3e-23 Glomerular filtration rate; LUSC cis rs8060686 0.668 rs255056 chr16:68016185 G/C cg27539214 chr16:67997921 SLC12A4 -0.45 -5.78 -0.3 1.75e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7507204 0.530 rs4807469 chr19:3443382 G/C cg08380311 chr19:3435252 NFIC 0.85 16.17 0.66 7.78e-44 Height; LUSC trans rs1005277 0.522 rs9418276 chr10:37940116 G/T cg17830980 chr10:43048298 ZNF37B -0.44 -7.05 -0.36 1.06e-11 Extrinsic epigenetic age acceleration; LUSC cis rs1832871 0.711 rs9457248 chr6:158681204 C/T cg07165851 chr6:158734300 TULP4 0.51 7.87 0.4 4.91e-14 Height; LUSC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg13175981 chr1:150552382 MCL1 0.44 5.9 0.31 8.83e-9 Urate levels; LUSC trans rs7507204 0.530 rs4807470 chr19:3443470 A/T cg08382705 chr11:45687319 CHST1 -0.48 -7.68 -0.39 1.79e-13 Height; LUSC cis rs2204008 0.702 rs3849999 chr12:38483498 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.63 -0.34 1.34e-10 Bladder cancer; LUSC cis rs7180079 1.000 rs6494475 chr15:64634884 C/A cg02848875 chr15:64387786 SNX1 0.4 5.76 0.3 1.92e-8 Monocyte count; LUSC cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg07636037 chr3:49044803 WDR6 0.93 14.84 0.63 1.3e-38 Parkinson's disease; LUSC cis rs7824557 0.767 rs1897951 chr8:11169854 C/T cg21775007 chr8:11205619 TDH 0.73 11.84 0.54 3.02e-27 Retinal vascular caliber; LUSC cis rs9427116 0.502 rs9427104 chr1:154589232 C/T cg17218026 chr1:154582156 ADAR 0.58 10.31 0.49 7.74e-22 Blood protein levels; LUSC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg07701084 chr6:150067640 NUP43 0.49 7.32 0.37 1.85e-12 Lung cancer; LUSC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs2197308 0.667 rs61920838 chr12:37856814 T/C cg26384229 chr12:38710491 ALG10B -0.82 -13.82 -0.6 1.12e-34 Morning vs. evening chronotype; LUSC cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg23711669 chr6:146136114 FBXO30 0.89 16.85 0.68 1.48e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs9486715 0.867 rs2475025 chr6:96988696 A/T cg06623918 chr6:96969491 KIAA0776 -0.94 -17.65 -0.69 1.06e-49 Headache; LUSC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg18305652 chr10:134549665 INPP5A 0.46 6.85 0.35 3.6e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC trans rs11098499 0.691 rs9996644 chr4:120238877 G/T cg25214090 chr10:38739885 LOC399744 0.43 6.41 0.33 5.04e-10 Corneal astigmatism; LUSC cis rs7674212 0.865 rs13149311 chr4:103977700 C/T cg16532752 chr4:104119610 CENPE -0.41 -5.77 -0.3 1.85e-8 Type 2 diabetes; LUSC cis rs6541297 1.000 rs4846836 chr1:230281316 G/A cg05784532 chr1:230284198 GALNT2 0.5 7.45 0.38 7.91e-13 Coronary artery disease; LUSC cis rs11098499 0.779 rs7356491 chr4:120381974 C/T cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.54e-25 Corneal astigmatism; LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg16031515 chr1:205743344 RAB7L1 -0.27 -5.92 -0.31 8.15e-9 Menarche (age at onset); LUSC cis rs11711311 0.955 rs34458493 chr3:113396473 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.98 -0.31 5.72e-9 IgG glycosylation; LUSC cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -8.77 -0.43 9.18e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs8044995 0.501 rs73613999 chr16:68390099 C/A cg09835421 chr16:68378352 PRMT7 -0.77 -8.56 -0.42 4.3e-16 Schizophrenia; LUSC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.77 0.39 9.46e-14 Parkinson's disease; LUSC trans rs6502050 0.805 rs56020943 chr17:80105248 C/A cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg22800045 chr5:56110881 MAP3K1 0.74 9.54 0.46 3.05e-19 Initial pursuit acceleration; LUSC cis rs921665 0.831 rs4337500 chr2:3190786 T/C cg02624386 chr2:3182749 NA 0.59 6.58 0.34 1.8e-10 World class endurance athleticism; LUSC cis rs1008375 1.000 rs10939744 chr4:17664473 G/T cg04450456 chr4:17643702 FAM184B 0.4 6.71 0.34 8.17e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg01420254 chr6:26195488 NA 0.72 7.45 0.38 8.01e-13 Gout;Renal underexcretion gout; LUSC cis rs317689 0.658 rs490872 chr12:69645864 A/G cg20891283 chr12:69753455 YEATS4 0.43 5.8 0.3 1.57e-8 Response to diuretic therapy; LUSC cis rs9300255 0.566 rs1716169 chr12:123716930 A/T cg00376283 chr12:123451042 ABCB9 0.68 7.74 0.39 1.19e-13 Neutrophil percentage of white cells; LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg08859206 chr1:53392774 SCP2 -0.54 -9.35 -0.46 1.34e-18 Monocyte count; LUSC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.08 -0.48 4.83e-21 Obesity-related traits; LUSC trans rs1409005 1.000 rs76429909 chr13:79161195 G/T cg04653021 chr3:122514541 DIRC2 0.47 6.0 0.31 5.25e-9 Serum thyroid-stimulating hormone levels; LUSC cis rs2806561 0.664 rs55764475 chr1:23318983 C/T cg19743168 chr1:23544995 NA 0.39 7.27 0.37 2.51e-12 Height; LUSC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg01579765 chr21:45077557 HSF2BP -0.49 -10.42 -0.5 3.44e-22 Mean corpuscular volume; LUSC cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.76e-11 Intelligence (multi-trait analysis); LUSC cis rs7980687 0.657 rs10744151 chr12:123723735 G/C cg00376283 chr12:123451042 ABCB9 0.69 9.84 0.47 3.25e-20 Height;Educational attainment;Head circumference (infant); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17783671 chr19:59070436 UBE2M;LOC100131691 -0.54 -6.59 -0.34 1.72e-10 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.806 rs4888390 chr16:75400320 G/A cg03315344 chr16:75512273 CHST6 0.49 9.33 0.45 1.48e-18 Dupuytren's disease; LUSC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg06238570 chr21:40685208 BRWD1 0.6 9.97 0.48 1.11e-20 Cognitive function; LUSC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.78 0.3 1.7e-8 Menopause (age at onset); LUSC cis rs2617583 0.509 rs10630 chr5:1462720 G/A cg13982541 chr5:1466431 LPCAT1 0.41 5.74 0.3 2.12e-8 Breast cancer; LUSC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.56 0.5 1.1e-22 Schizophrenia; LUSC cis rs977987 0.835 rs3851734 chr16:75371920 T/C cg03315344 chr16:75512273 CHST6 0.49 9.4 0.46 8.79e-19 Dupuytren's disease; LUSC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg20891283 chr12:69753455 YEATS4 0.79 14.5 0.62 2.8e-37 Blood protein levels; LUSC cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg23711669 chr6:146136114 FBXO30 0.88 16.26 0.66 3.3e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg11057378 chr10:81107060 PPIF 0.38 6.29 0.33 9.67e-10 Height; LUSC cis rs6964587 0.740 rs2020360 chr7:91439506 G/C cg17063962 chr7:91808500 NA 0.58 8.83 0.44 6.01e-17 Breast cancer; LUSC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.53 -6.82 -0.35 4.33e-11 Multiple sclerosis; LUSC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg15605315 chr1:45957053 TESK2 0.49 8.12 0.41 9.19e-15 High light scatter reticulocyte count; LUSC cis rs28655083 0.956 rs7184198 chr16:77069490 T/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.42 -6.43 -0.33 4.39e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs12908161 1.000 rs12911736 chr15:85240008 A/G cg11189052 chr15:85197271 WDR73 0.48 5.93 0.31 7.56e-9 Schizophrenia; LUSC cis rs36093844 0.904 rs7113656 chr11:85594739 T/C cg25872744 chr11:85566296 CCDC83 -0.42 -6.89 -0.35 2.71e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg18538332 chr22:24372958 LOC391322 0.47 8.13 0.41 8.28e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg18765753 chr7:1198926 ZFAND2A -0.48 -8.3 -0.41 2.62e-15 Longevity;Endometriosis; LUSC cis rs9394438 0.628 rs804843 chr6:37545923 A/G cg00985040 chr6:37553208 NA -0.39 -9.11 -0.45 7.79e-18 IgG glycosylation; LUSC trans rs7937682 0.889 rs564086 chr11:111501079 C/G cg18187862 chr3:45730750 SACM1L 0.55 7.0 0.36 1.43e-11 Primary sclerosing cholangitis; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg14893161 chr1:205819251 PM20D1 0.92 18.09 0.7 1.75e-51 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04943085 chr2:73340257 RAB11FIP5 -0.4 -5.95 -0.31 6.77e-9 Electrocardiographic conduction measures; LUSC cis rs16854884 1.000 rs16854886 chr3:143781492 A/G cg06585982 chr3:143692056 C3orf58 0.46 6.43 0.33 4.37e-10 Economic and political preferences (feminism/equality); LUSC cis rs6752107 0.967 rs12162308 chr2:234172188 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.51 0.53 4.64e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 8.21 0.41 5.03e-15 Colorectal cancer; LUSC cis rs12824058 0.737 rs873663 chr12:130816316 C/T cg24838063 chr12:130822603 PIWIL1 0.7 10.36 0.49 5.41e-22 Menopause (age at onset); LUSC cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.54 8.34 0.42 1.98e-15 Colorectal cancer; LUSC cis rs7408868 1.000 rs2074617 chr19:15276055 C/G cg14696996 chr19:15285081 NOTCH3 1.02 9.38 0.46 1.03e-18 Pulse pressure; LUSC cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg08085267 chr17:45401833 C17orf57 0.54 8.8 0.43 7.36e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6469656 1.000 rs10505286 chr8:117727804 A/T cg24004040 chr8:117650383 NA 0.44 6.46 0.33 3.81e-10 Colorectal cancer; LUSC trans rs12310956 0.532 rs1352210 chr12:33983187 A/G cg26384229 chr12:38710491 ALG10B 0.65 10.29 0.49 9.41e-22 Morning vs. evening chronotype; LUSC cis rs4253772 0.514 rs11704878 chr22:46714664 C/T cg24881330 chr22:46731750 TRMU 0.83 7.52 0.38 5e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs7589342 0.501 rs13429800 chr2:106441002 C/T cg14210321 chr2:106509881 NCK2 -0.41 -6.13 -0.32 2.54e-9 Addiction; LUSC cis rs10193935 0.901 rs62142596 chr2:42529339 C/T cg27598129 chr2:42591480 NA -0.6 -8.34 -0.42 1.94e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs12760731 0.720 rs12022731 chr1:178416358 A/G cg00404053 chr1:178313656 RASAL2 0.59 6.22 0.32 1.46e-9 Obesity-related traits; LUSC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg03806693 chr22:41940476 POLR3H 0.99 13.71 0.6 3.01e-34 Crohn's disease;Inflammatory bowel disease; LUSC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg06850241 chr22:41845214 NA 0.34 6.3 0.33 9.5e-10 Vitiligo; LUSC cis rs5769707 0.521 rs5769720 chr22:50062133 G/C cg05373962 chr22:49881684 NA -0.39 -8.25 -0.41 3.62e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4654899 0.865 rs957163 chr1:21416181 G/T cg02927042 chr1:21476669 EIF4G3 -0.4 -6.3 -0.33 9.29e-10 Superior frontal gyrus grey matter volume; LUSC cis rs2839186 0.843 rs17182671 chr21:47696238 T/C cg13126279 chr21:47581558 C21orf56 -0.43 -6.37 -0.33 6.09e-10 Testicular germ cell tumor; LUSC cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs8078723 0.933 rs55846942 chr17:38164470 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.94 -0.36 1.99e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.36e-12 Motion sickness; LUSC trans rs2204008 0.599 rs2320526 chr12:38220405 T/A cg06521331 chr12:34319734 NA -0.4 -6.21 -0.32 1.59e-9 Bladder cancer; LUSC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg12365402 chr11:9010492 NRIP3 -0.52 -10.14 -0.49 3.05e-21 Hemoglobin concentration; LUSC cis rs8017423 0.647 rs4904679 chr14:90821801 C/T cg04374321 chr14:90722782 PSMC1 -0.43 -6.51 -0.34 2.72e-10 Mortality in heart failure; LUSC cis rs1609391 0.567 rs835633 chr3:136676496 T/C cg21827317 chr3:136751795 NA 0.39 6.9 0.35 2.67e-11 Neuroticism; LUSC cis rs7843479 0.965 rs1484162 chr8:21831385 A/G cg17168535 chr8:21777572 XPO7 0.67 10.28 0.49 1.06e-21 Mean corpuscular volume; LUSC cis rs7180079 0.544 rs11071804 chr15:64975763 C/G cg08069370 chr15:64387884 SNX1 0.53 5.83 0.3 1.29e-8 Monocyte count; LUSC cis rs3126085 0.935 rs11204943 chr1:152203906 A/C cg26876637 chr1:152193138 HRNR 0.45 6.29 0.33 9.81e-10 Atopic dermatitis; LUSC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15506890 chr2:3487001 NA -0.57 -9.3 -0.45 1.88e-18 Neurofibrillary tangles; LUSC cis rs9952991 0.883 rs2542148 chr18:12777573 C/G cg23544223 chr18:12777786 NA 0.59 6.25 0.32 1.26e-9 Inflammatory skin disease; LUSC trans rs7824557 0.767 rs6985146 chr8:11170721 A/C cg06636001 chr8:8085503 FLJ10661 0.54 7.87 0.4 5.15e-14 Retinal vascular caliber; LUSC cis rs2839186 0.504 rs11702278 chr21:47936295 T/G cg12379764 chr21:47803548 PCNT 0.81 13.26 0.59 1.57e-32 Testicular germ cell tumor; LUSC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg13683864 chr3:40499215 RPL14 -1.12 -21.74 -0.77 6.43e-66 Renal cell carcinoma; LUSC cis rs6429082 0.518 rs1812350 chr1:235659920 C/A cg26050004 chr1:235667680 B3GALNT2 0.81 14.14 0.61 6.81e-36 Adiposity; LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.12 -0.32 2.59e-9 Developmental language disorder (linguistic errors); LUSC cis rs9650657 0.648 rs7833945 chr8:10700266 T/G cg27411982 chr8:10470053 RP1L1 -0.39 -6.39 -0.33 5.55e-10 Neuroticism; LUSC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.64 0.5 5.72e-23 Homoarginine levels; LUSC cis rs870825 0.616 rs6552805 chr4:185637894 C/A cg04058563 chr4:185651563 MLF1IP 0.88 13.29 0.59 1.19e-32 Blood protein levels; LUSC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg27170947 chr2:26402098 FAM59B -0.64 -9.43 -0.46 7.05e-19 Gut microbiome composition (summer); LUSC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg22875332 chr1:76189707 ACADM 0.82 14.09 0.61 1.02e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2404602 0.716 rs4886817 chr15:76877702 C/T cg23625390 chr15:77176239 SCAPER 0.46 7.11 0.36 6.92e-12 Blood metabolite levels; LUSC cis rs7584330 0.737 rs6758246 chr2:238359891 G/C cg14458575 chr2:238380390 NA 0.69 12.18 0.55 1.66e-28 Prostate cancer; LUSC cis rs2798269 0.528 rs9509802 chr13:22148698 C/T cg18095732 chr13:22033692 ZDHHC20 -0.42 -6.81 -0.35 4.49e-11 PR segment; LUSC trans rs1325195 0.734 rs2791943 chr1:179107430 T/C cg11624085 chr17:8464688 MYH10 0.42 6.85 0.35 3.5e-11 IgE grass sensitization; LUSC cis rs6582630 0.555 rs11503799 chr12:38294578 G/A cg13010199 chr12:38710504 ALG10B -0.46 -6.81 -0.35 4.42e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg13939156 chr17:80058883 NA -0.34 -6.75 -0.35 6.61e-11 Life satisfaction; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs9648716 0.515 rs809005 chr7:140721242 C/A cg23214464 chr7:140373596 ADCK2 -0.72 -6.24 -0.32 1.34e-9 Type 2 diabetes; LUSC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg16405210 chr4:1374714 KIAA1530 -0.54 -8.46 -0.42 8.72e-16 Obesity-related traits; LUSC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg07061783 chr6:25882402 NA -0.4 -5.85 -0.3 1.17e-8 Blood metabolite levels; LUSC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.06 0.31 3.75e-9 Personality dimensions; LUSC cis rs9611565 0.608 rs2003816 chr22:42095140 T/G cg03806693 chr22:41940476 POLR3H 0.88 12.58 0.57 5.59e-30 Vitiligo; LUSC cis rs12908161 1.000 rs12905057 chr15:85210765 A/G cg17507749 chr15:85114479 UBE2QP1 0.56 6.91 0.35 2.41e-11 Schizophrenia; LUSC cis rs4595586 0.545 rs2388179 chr12:39364036 T/A cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.07e-12 Morning vs. evening chronotype; LUSC cis rs6951245 0.882 rs11764817 chr7:1064610 T/C cg22907277 chr7:1156413 C7orf50 0.5 5.75 0.3 2.01e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg00684032 chr4:1343700 KIAA1530 0.33 5.81 0.3 1.49e-8 Obesity-related traits; LUSC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg21535942 chr1:75199100 CRYZ;TYW3 0.47 7.51 0.38 5.34e-13 Resistin levels; LUSC cis rs10791097 0.765 rs4622274 chr11:130729486 C/T cg12179176 chr11:130786555 SNX19 0.73 11.94 0.55 1.32e-27 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg08048268 chr3:133502702 NA -0.46 -9.0 -0.44 1.74e-17 Iron status biomarkers; LUSC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg03233332 chr7:66118400 NA -0.43 -6.26 -0.32 1.19e-9 Aortic root size; LUSC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg15369054 chr17:80825471 TBCD -0.41 -6.64 -0.34 1.27e-10 Breast cancer; LUSC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg00339695 chr16:24857497 SLC5A11 -0.62 -9.67 -0.47 1.2e-19 Intelligence (multi-trait analysis); LUSC cis rs11785400 0.963 rs6990126 chr8:143728387 T/C cg24634471 chr8:143751801 JRK 0.6 8.98 0.44 1.95e-17 Schizophrenia; LUSC trans rs11098499 0.644 rs10009566 chr4:120558608 A/G cg25214090 chr10:38739885 LOC399744 0.41 6.26 0.32 1.18e-9 Corneal astigmatism; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10659575 chr11:102188233 BIRC3 0.41 6.32 0.33 8.38e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs75804782 0.521 rs55973123 chr2:239416264 G/A cg18131467 chr2:239335373 ASB1 -0.62 -5.95 -0.31 6.81e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs920590 0.758 rs1907799 chr8:19664668 A/G cg03894339 chr8:19674705 INTS10 -0.51 -7.08 -0.36 8.75e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg19539972 chr4:7069911 GRPEL1 0.71 8.87 0.44 4.66e-17 Monocyte percentage of white cells; LUSC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg00677455 chr12:58241039 CTDSP2 0.62 8.7 0.43 1.52e-16 Multiple sclerosis; LUSC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg11301795 chr4:187892539 NA -0.8 -15.54 -0.65 2.27e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs854765 0.547 rs4643387 chr17:17972973 C/T cg04398451 chr17:18023971 MYO15A -0.57 -9.66 -0.47 1.29e-19 Total body bone mineral density; LUSC cis rs472402 0.540 rs3776431 chr5:6618756 T/C cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.51 -7.41 -0.38 1.01e-12 Response to amphetamines; LUSC cis rs7605827 0.866 rs9710889 chr2:15533779 G/A cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg12365402 chr11:9010492 NRIP3 0.43 7.91 0.4 3.84e-14 Hemoglobin concentration; LUSC cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg14844989 chr11:31128820 NA -0.39 -6.09 -0.32 3.1e-9 Red blood cell count; LUSC cis rs240764 0.817 rs12216304 chr6:101174161 A/G cg09795085 chr6:101329169 ASCC3 -0.41 -5.91 -0.31 8.31e-9 Neuroticism; LUSC trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs6546550 0.743 rs6731941 chr2:70018496 A/G cg02498382 chr2:70120550 SNRNP27 -0.26 -6.23 -0.32 1.41e-9 Prevalent atrial fibrillation; LUSC cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg20848291 chr7:100343083 ZAN -0.68 -9.44 -0.46 6.61e-19 Other erythrocyte phenotypes; LUSC cis rs6138458 1.000 rs227630 chr20:24913584 A/G cg26195577 chr20:24973756 C20orf3 1.11 18.4 0.71 1.06e-52 Blood protein levels; LUSC trans rs1728785 0.786 rs1728770 chr16:68564124 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.63 0.39 2.44e-13 Ulcerative colitis; LUSC cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -11.68 -0.54 1.17e-26 Chronic sinus infection; LUSC cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg20503657 chr10:835505 NA -0.49 -6.86 -0.35 3.31e-11 Response to angiotensin II receptor blocker therapy; LUSC trans rs57046232 0.552 rs6054184 chr20:6354592 A/G cg17788362 chr6:86352627 SYNCRIP 0.43 6.07 0.32 3.44e-9 Colorectal cancer; LUSC cis rs1160297 0.585 rs12614959 chr2:53090302 T/C cg07782112 chr2:53107842 NA 0.4 6.44 0.33 4.27e-10 Hemostatic factors and hematological phenotypes; LUSC trans rs2700987 0.716 rs1986568 chr7:37386824 G/C cg26076750 chr5:98105150 RGMB -0.37 -6.64 -0.34 1.28e-10 Psoriasis vulgaris;Psoriasis; LUSC cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg13256891 chr4:100009986 ADH5 0.41 5.91 0.31 8.51e-9 Alcohol dependence; LUSC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.36 -0.33 6.67e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg08677398 chr8:58056175 NA 0.52 7.2 0.37 4.08e-12 Developmental language disorder (linguistic errors); LUSC cis rs7258465 1.000 rs4808804 chr19:18585325 A/G cg11102782 chr19:18549136 ISYNA1 -0.35 -6.36 -0.33 6.65e-10 Breast cancer; LUSC cis rs2777491 0.957 rs6493002 chr15:41709195 C/G cg18705301 chr15:41695430 NDUFAF1 -0.72 -13.66 -0.6 4.63e-34 Ulcerative colitis; LUSC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg12463550 chr7:65579703 CRCP 0.42 6.04 0.31 4.03e-9 Aortic root size; LUSC trans rs853679 0.607 rs56189111 chr6:28271973 C/A cg06606381 chr12:133084897 FBRSL1 -0.99 -9.35 -0.46 1.33e-18 Depression; LUSC cis rs72627509 0.638 rs7658601 chr4:57781347 C/T cg26694713 chr4:57773883 REST 0.52 6.36 0.33 6.5e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg03433033 chr1:76189801 ACADM 0.8 13.09 0.58 7.15e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg06008330 chr7:65541103 ASL -0.4 -6.16 -0.32 2.14e-9 Aortic root size; LUSC cis rs654950 0.775 rs28972757 chr1:41993013 T/C cg06885757 chr1:42089581 HIVEP3 -0.37 -7.28 -0.37 2.44e-12 Airway imaging phenotypes; LUSC cis rs2777491 0.915 rs7178777 chr15:41634588 C/A cg18705301 chr15:41695430 NDUFAF1 -0.76 -14.42 -0.62 5.41e-37 Ulcerative colitis; LUSC trans rs7824557 0.544 rs1865521 chr8:11231249 T/C cg08975724 chr8:8085496 FLJ10661 0.48 7.07 0.36 9.25e-12 Retinal vascular caliber; LUSC cis rs11690935 0.959 rs12692970 chr2:172594197 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.42 -0.62 5.29e-37 Schizophrenia; LUSC cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg11266682 chr4:10021025 SLC2A9 0.46 7.81 0.39 7.37e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7814319 0.899 rs1878638 chr8:97258719 C/T cg20787634 chr8:97240163 UQCRB -0.34 -5.94 -0.31 7.3e-9 Lung function (FVC); LUSC cis rs757081 0.608 rs214938 chr11:17188516 C/T cg15432903 chr11:17409602 KCNJ11 -0.39 -5.98 -0.31 5.7e-9 Systolic blood pressure; LUSC trans rs1864729 0.818 rs2583510 chr8:98294452 A/G cg08679828 chr8:102218111 ZNF706 -0.72 -6.16 -0.32 2.1e-9 Estradiol plasma levels (breast cancer); LUSC cis rs6967385 0.934 rs2098364 chr7:12368783 C/A cg20607287 chr7:12443886 VWDE 0.4 5.84 0.3 1.25e-8 Response to taxane treatment (placlitaxel); LUSC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg20607287 chr7:12443886 VWDE -0.61 -6.34 -0.33 7.27e-10 Coronary artery disease; LUSC cis rs7584330 0.554 rs9646716 chr2:238443784 C/T cg16989719 chr2:238392110 NA -0.41 -5.97 -0.31 6.05e-9 Prostate cancer; LUSC cis rs4901869 0.966 rs4901868 chr14:59333792 C/T cg02291164 chr14:59296302 NA -0.56 -10.65 -0.5 5.44e-23 Panic disorder; LUSC cis rs10782582 0.545 rs111927462 chr1:76195422 A/G cg03433033 chr1:76189801 ACADM -0.46 -6.66 -0.34 1.11e-10 Daytime sleep phenotypes; LUSC cis rs12928939 0.911 rs7202840 chr16:71824714 C/T cg03805757 chr16:71968109 PKD1L3 -0.46 -6.65 -0.34 1.23e-10 Post bronchodilator FEV1; LUSC cis rs3796352 1.000 rs11712653 chr3:53070875 A/C cg07884673 chr3:53033167 SFMBT1 -0.77 -7.81 -0.39 7.4e-14 Immune reponse to smallpox (secreted IL-2); LUSC cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg13010199 chr12:38710504 ALG10B 0.68 10.59 0.5 8.41e-23 Bladder cancer; LUSC cis rs11190604 1.000 rs6584383 chr10:102303065 C/G cg07080220 chr10:102295463 HIF1AN 0.67 8.92 0.44 3.14e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7824557 0.767 rs2164272 chr8:11162496 A/C cg21775007 chr8:11205619 TDH 0.71 11.36 0.53 1.72e-25 Retinal vascular caliber; LUSC trans rs12692738 0.526 rs355861 chr2:165629963 A/G cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs2018683 0.834 rs733485 chr7:29026685 C/A cg19402173 chr7:128379420 CALU -0.56 -9.16 -0.45 5.4e-18 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs8077577 0.895 rs1563371 chr17:18111793 C/T cg16794390 chr17:18148240 FLII 0.41 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs6546537 1.000 rs6712370 chr2:69855094 C/G cg10773587 chr2:69614142 GFPT1 0.51 7.53 0.38 4.87e-13 Serum thyroid-stimulating hormone levels; LUSC trans rs6502050 0.799 rs7502524 chr17:80107261 C/T cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs11098499 0.954 rs10006877 chr4:120242793 C/T cg09307838 chr4:120376055 NA 0.82 12.07 0.55 4.44e-28 Corneal astigmatism; LUSC cis rs4132509 1.000 rs12403316 chr1:243956903 C/T cg21452805 chr1:244014465 NA 0.5 5.82 0.3 1.41e-8 RR interval (heart rate); LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg25767906 chr1:53392781 SCP2 -0.5 -9.21 -0.45 3.66e-18 Monocyte count; LUSC cis rs2486288 0.656 rs7165039 chr15:45570413 C/G cg09092052 chr15:45571596 NA 0.47 6.53 0.34 2.42e-10 Glomerular filtration rate; LUSC cis rs7267979 1.000 rs6050590 chr20:25384994 G/A cg08601574 chr20:25228251 PYGB -0.42 -6.49 -0.33 3.1e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg13298116 chr11:62369859 EML3;MTA2 0.59 9.59 0.46 2.1e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6582630 0.548 rs8189608 chr12:38327775 T/G cg26384229 chr12:38710491 ALG10B -0.53 -7.8 -0.39 7.98e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg23711669 chr6:146136114 FBXO30 0.86 15.54 0.65 2.22e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs7267979 0.702 rs449801 chr20:25491847 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.78 15.43 0.65 6.07e-41 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2481665 0.772 rs6668600 chr1:62536683 C/G cg18591186 chr1:62594603 INADL 0.49 7.9 0.4 4.12e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg11764359 chr7:65958608 NA 0.54 7.05 0.36 1.04e-11 Aortic root size; LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg18404041 chr3:52824283 ITIH1 -0.55 -10.47 -0.5 2.33e-22 Bipolar disorder; LUSC cis rs2200578 0.841 rs111592987 chr2:99601250 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 0.63 7.56 0.38 3.97e-13 IgG glycosylation; LUSC cis rs9653442 0.675 rs2871326 chr2:100662010 T/C cg07810366 chr2:100720526 AFF3 -0.43 -7.19 -0.37 4.29e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs250677 0.522 rs919731 chr5:148352150 T/C cg18129178 chr5:148520854 ABLIM3 0.54 7.6 0.38 2.97e-13 Breast cancer; LUSC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs17401966 0.931 rs2276100 chr1:10394536 C/G cg19773385 chr1:10388646 KIF1B -0.57 -9.79 -0.47 4.78e-20 Hepatocellular carcinoma; LUSC cis rs3916 0.911 rs12829722 chr12:121155622 C/T cg27246729 chr12:121163418 ACADS 0.48 6.86 0.35 3.45e-11 Urinary metabolites (H-NMR features); LUSC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg05340658 chr4:99064831 C4orf37 -0.69 -11.88 -0.55 2.15e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.42 0.46 7.53e-19 Bipolar disorder; LUSC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg04166393 chr7:2884313 GNA12 0.43 5.75 0.3 2.06e-8 Height; LUSC cis rs1440410 0.835 rs7684481 chr4:144054405 C/G cg01719995 chr4:144104893 USP38 0.32 5.84 0.3 1.22e-8 Ischemic stroke; LUSC cis rs7212590 0.618 rs59767604 chr17:58041339 C/G cg10252138 chr17:58120427 NA -0.79 -7.51 -0.38 5.45e-13 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.54 -7.18 -0.37 4.57e-12 Renal function-related traits (BUN); LUSC cis rs68170813 0.523 rs79607134 chr7:107033619 A/T cg02696742 chr7:106810147 HBP1 -0.61 -8.98 -0.44 1.96e-17 Coronary artery disease; LUSC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg16797656 chr11:68205561 LRP5 -0.34 -5.69 -0.3 2.78e-8 Total body bone mineral density; LUSC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.04 -0.44 1.25e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7953508 0.711 rs3825198 chr12:93977465 T/A cg18151635 chr12:93972918 NA -0.56 -7.96 -0.4 2.79e-14 Pubertal anthropometrics; LUSC cis rs12681287 0.547 rs6985066 chr8:87526439 A/C cg00550725 chr8:87521180 FAM82B 0.43 5.66 0.3 3.21e-8 Caudate activity during reward; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg07362569 chr17:61921086 SMARCD2 0.36 7.35 0.37 1.51e-12 Prudent dietary pattern; LUSC cis rs7923609 0.967 rs3956912 chr10:65205881 C/T cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.03e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg24675658 chr1:53192096 ZYG11B 0.58 9.02 0.44 1.54e-17 Monocyte count; LUSC cis rs4285028 0.747 rs9852845 chr3:121390618 A/C cg11130432 chr3:121712080 ILDR1 -0.56 -8.13 -0.41 8.7e-15 Multiple sclerosis; LUSC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg16606324 chr3:10149918 C3orf24 0.62 9.45 0.46 6.19e-19 Alzheimer's disease; LUSC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg19046167 chr17:80928561 B3GNTL1 0.48 6.93 0.35 2.2e-11 Glycated hemoglobin levels; LUSC cis rs34779708 0.931 rs7908573 chr10:35309513 T/C cg04310649 chr10:35416472 CREM -0.4 -6.04 -0.31 4.2e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11997175 0.646 rs4609158 chr8:33693420 A/G ch.8.33884649F chr8:33765107 NA 0.46 7.0 0.36 1.44e-11 Body mass index; LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg06263672 chr7:65235340 NA 0.42 6.07 0.32 3.53e-9 Calcium levels; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg24739457 chr1:205821442 NA 0.35 6.0 0.31 5.22e-9 Menarche (age at onset); LUSC trans rs1005277 0.540 rs2474598 chr10:38430296 C/T cg17830980 chr10:43048298 ZNF37B 0.57 9.25 0.45 2.8e-18 Extrinsic epigenetic age acceleration; LUSC cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg01689657 chr7:91764605 CYP51A1 0.33 6.06 0.31 3.6e-9 Breast cancer; LUSC cis rs10089 0.552 rs1351141 chr5:127550055 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.66 -8.46 -0.42 8.39e-16 Ileal carcinoids; LUSC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg05527609 chr1:210001259 C1orf107 -0.4 -5.92 -0.31 8.19e-9 Monobrow; LUSC cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg08754478 chr10:133766260 PPP2R2D -0.6 -7.34 -0.37 1.67e-12 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.38 0.33 6.05e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs2073300 1.000 rs6132625 chr20:23444671 C/T cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs3733585 0.673 rs7375587 chr4:9954758 A/T cg26043149 chr18:55253948 FECH 0.46 7.19 0.37 4.36e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg23262073 chr20:60523788 NA -0.43 -6.02 -0.31 4.47e-9 Body mass index; LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg22166914 chr1:53195759 ZYG11B -0.49 -7.65 -0.39 2.23e-13 Monocyte count; LUSC cis rs6545883 0.831 rs2592356 chr2:61810428 G/C cg15711740 chr2:61764176 XPO1 -0.46 -7.37 -0.37 1.34e-12 Tuberculosis; LUSC cis rs3892630 0.612 rs10413282 chr19:33182751 A/G cg22980127 chr19:33182716 NUDT19 0.97 15.01 0.63 2.66e-39 Red blood cell traits; LUSC cis rs765787 0.530 rs12905246 chr15:45500841 C/T cg24006582 chr15:45444508 DUOX1 0.69 10.0 0.48 9.11e-21 Uric acid levels; LUSC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg10909506 chr17:38081995 ORMDL3 0.34 6.08 0.32 3.34e-9 Self-reported allergy; LUSC cis rs6831352 0.851 rs1230164 chr4:99986023 C/G cg12011299 chr4:100065546 ADH4 0.65 9.82 0.47 3.77e-20 Alcohol dependence; LUSC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg12463550 chr7:65579703 CRCP 0.62 5.67 0.3 3.04e-8 Diabetic kidney disease; LUSC cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg14844989 chr11:31128820 NA -0.37 -5.74 -0.3 2.1e-8 Red blood cell count; LUSC cis rs10791111 1 rs10791111 chr11:130856099 T/G cg12179176 chr11:130786555 SNX19 0.63 9.47 0.46 5.34e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs977987 0.806 rs56343285 chr16:75409797 A/G cg04384234 chr16:75411784 CFDP1 -0.42 -6.85 -0.35 3.49e-11 Dupuytren's disease; LUSC cis rs2836633 0.929 rs62217517 chr21:40033177 T/A cg12884169 chr21:40033163 ERG 0.61 12.26 0.56 8.41e-29 Coronary artery disease; LUSC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg04546413 chr19:29218101 NA -0.59 -7.77 -0.39 9.56e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9814567 0.896 rs10935123 chr3:134345327 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.97 -0.61 2.98e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6500395 0.962 rs13331902 chr16:48644989 A/G cg04672837 chr16:48644449 N4BP1 0.47 6.66 0.34 1.16e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4285028 0.580 rs1523519 chr3:121631841 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.51 -7.2 -0.37 3.92e-12 Multiple sclerosis; LUSC trans rs4332037 0.851 rs10268609 chr7:1962163 A/C cg25206134 chr2:45395956 NA 0.54 6.44 0.33 4.06e-10 Bipolar disorder; LUSC cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg03146154 chr1:46216737 IPP 0.55 8.21 0.41 5.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7909074 1.000 rs4948926 chr10:45392604 G/C cg04218760 chr10:45406644 TMEM72 -0.31 -7.53 -0.38 4.69e-13 Mean corpuscular volume; LUSC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg08470875 chr2:26401718 FAM59B -0.64 -8.58 -0.42 3.75e-16 Gut microbiome composition (summer); LUSC cis rs11122272 0.705 rs1416914 chr1:231533196 C/T cg06096015 chr1:231504339 EGLN1 0.56 9.93 0.48 1.56e-20 Hemoglobin concentration; LUSC trans rs4811340 0.561 rs6063828 chr20:51173568 G/T cg15736553 chr3:11610338 VGLL4 -0.34 -6.06 -0.31 3.74e-9 Thyroid peroxidase antibody positivity; LUSC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18099408 chr3:52552593 STAB1 -0.42 -7.39 -0.37 1.17e-12 Electroencephalogram traits; LUSC cis rs523522 0.962 rs603574 chr12:120998443 A/G cg27279351 chr12:120934652 DYNLL1 0.65 8.79 0.43 8.03e-17 High light scatter reticulocyte count; LUSC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg18876405 chr7:65276391 NA -0.7 -12.65 -0.57 3.22e-30 Aortic root size; LUSC cis rs3540 0.533 rs2256097 chr15:90971331 A/T cg04176472 chr15:90893244 GABARAPL3 0.35 6.27 0.32 1.1e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs6121246 0.909 rs6060821 chr20:30294034 C/T cg18721089 chr20:30220636 NA -0.35 -6.0 -0.31 5.1e-9 Mean corpuscular hemoglobin; LUSC cis rs5758511 0.689 rs56906457 chr22:42628335 A/G cg12850546 chr22:42539477 CYP2D7P1 -0.58 -6.91 -0.35 2.47e-11 Birth weight; LUSC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.23 0.52 4.91e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs8017423 0.967 rs7142513 chr14:90705182 T/C cg04374321 chr14:90722782 PSMC1 0.7 10.69 0.5 3.9699999999999997e-23 Mortality in heart failure; LUSC cis rs7944735 0.578 rs7949985 chr11:48062449 C/T cg20307385 chr11:47447363 PSMC3 -0.64 -5.83 -0.3 1.31e-8 Intraocular pressure; LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.27 0.37 2.52e-12 Bipolar disorder; LUSC trans rs6952808 0.893 rs35487994 chr7:1920171 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 6.18 0.32 1.87e-9 Bipolar disorder and schizophrenia; LUSC trans rs1268789 0.545 rs2054721 chr4:79351249 C/A cg06112894 chr8:141469983 TRAPPC9 0.22 5.96 0.31 6.33e-9 Hair shape;Hair morphology; LUSC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.59 -9.59 -0.46 2.12e-19 Personality dimensions; LUSC cis rs453301 0.686 rs3989373 chr8:8911308 G/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.39 -0.37 1.18e-12 Joint mobility (Beighton score); LUSC cis rs6604026 0.524 rs532834 chr1:93468062 A/T cg17283838 chr1:93427260 FAM69A 0.4 5.83 0.3 1.32e-8 Multiple sclerosis; LUSC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg23630131 chr7:65973040 NA 0.21 5.79 0.3 1.62e-8 Aortic root size; LUSC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg08219700 chr8:58056026 NA 0.47 6.27 0.32 1.1e-9 Developmental language disorder (linguistic errors); LUSC cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.73e-15 Homoarginine levels; LUSC trans rs6502050 0.835 rs7219180 chr17:80079968 C/G cg07393940 chr7:158741817 NA -0.37 -6.62 -0.34 1.46e-10 Life satisfaction; LUSC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg05373962 chr22:49881684 NA -0.41 -9.84 -0.47 3.06e-20 Monocyte count;Monocyte percentage of white cells; LUSC trans rs7824557 0.767 rs6985146 chr8:11170721 A/C cg08975724 chr8:8085496 FLJ10661 0.46 6.46 0.33 3.8e-10 Retinal vascular caliber; LUSC trans rs9329221 0.657 rs17694485 chr8:10114458 A/T cg15556689 chr8:8085844 FLJ10661 0.53 7.38 0.37 1.23e-12 Neuroticism; LUSC cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg24642439 chr20:33292090 TP53INP2 -0.5 -7.51 -0.38 5.6e-13 Glomerular filtration rate (creatinine); LUSC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs7582180 0.629 rs893416 chr2:100957443 G/A cg08017756 chr2:100939284 LONRF2 -0.47 -8.7 -0.43 1.49e-16 Intelligence (multi-trait analysis); LUSC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg02187348 chr16:89574699 SPG7 0.64 10.63 0.5 6.51e-23 Multiple myeloma (IgH translocation); LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg26668828 chr6:292823 DUSP22 -0.73 -12.02 -0.55 6.87e-28 Menopause (age at onset); LUSC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg23711669 chr6:146136114 FBXO30 0.9 17.22 0.69 5.08e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs1775715 0.677 rs2808105 chr10:32110907 C/T cg18675610 chr10:32216311 ARHGAP12 0.29 6.34 0.33 7.56e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg06634786 chr22:41940651 POLR3H 0.49 5.78 0.3 1.74e-8 Vitiligo; LUSC cis rs7937890 0.732 rs7946902 chr11:14273308 C/T cg05501817 chr11:14380813 RRAS2 0.43 6.14 0.32 2.38e-9 Mitochondrial DNA levels; LUSC trans rs6952808 0.792 rs4721184 chr7:1950784 T/C cg04565464 chr8:145669602 NFKBIL2 0.38 6.12 0.32 2.55e-9 Bipolar disorder and schizophrenia; LUSC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11890956 chr21:40555474 PSMG1 -0.75 -11.49 -0.53 5.82e-26 Menarche (age at onset); LUSC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg10792982 chr14:105748885 BRF1 0.49 9.03 0.44 1.41e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs1577917 0.958 rs884842 chr6:86680397 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -8.13 -0.41 8.66e-15 Response to antipsychotic treatment; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08940097 chr17:74094040 EXOC7 0.44 6.0 0.31 5.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg20503657 chr10:835505 NA -0.49 -6.8 -0.35 4.7e-11 Response to angiotensin II receptor blocker therapy; LUSC trans rs17039065 0.920 rs12508024 chr4:109413413 A/G cg07444054 chr2:108107501 NA -0.42 -5.99 -0.31 5.5e-9 Gut microbiome composition (summer); LUSC cis rs8133932 0.654 rs382303 chr21:47349284 G/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.8 -0.3 1.54e-8 Schizophrenia; LUSC cis rs10782582 0.593 rs12131493 chr1:76139172 G/A cg22875332 chr1:76189707 ACADM -0.4 -5.9 -0.31 8.76e-9 Daytime sleep phenotypes; LUSC cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg26528668 chr16:1614120 IFT140 0.45 7.53 0.38 4.86e-13 Coronary artery disease; LUSC cis rs10886558 0.674 rs78755284 chr10:121802984 T/C cg02041677 chr10:121771263 NA -0.34 -6.27 -0.32 1.13e-9 Shingles; LUSC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.86e-9 Major depressive disorder; LUSC cis rs7084921 0.579 rs2862951 chr10:101844948 A/C cg11888571 chr10:102027403 CWF19L1 -0.44 -6.08 -0.32 3.21e-9 Bone mineral density; LUSC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg05110241 chr16:68378359 PRMT7 -0.58 -6.72 -0.35 7.89e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs12908161 1.000 rs58416181 chr15:85264461 G/A cg12863693 chr15:85201151 NMB 0.43 8.86 0.44 4.77e-17 Schizophrenia; LUSC cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg13010199 chr12:38710504 ALG10B 0.68 11.04 0.52 2.23e-24 Heart rate; LUSC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg16434002 chr17:42200994 HDAC5 0.44 5.81 0.3 1.48e-8 Total body bone mineral density; LUSC cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg23711669 chr6:146136114 FBXO30 0.84 15.28 0.64 2.38e-40 Lobe attachment (rater-scored or self-reported); LUSC trans rs3733585 0.699 rs6449157 chr4:9960442 G/A cg26043149 chr18:55253948 FECH -0.44 -6.8 -0.35 4.9e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg20399509 chr21:47717575 C21orf57 -0.38 -5.73 -0.3 2.29e-8 Testicular germ cell tumor; LUSC trans rs7613875 0.537 rs6446195 chr3:50070853 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -7.97 -0.4 2.53e-14 Body mass index; LUSC cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg24642439 chr20:33292090 TP53INP2 -0.5 -7.5 -0.38 5.92e-13 Glomerular filtration rate (creatinine); LUSC cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg15105969 chr2:36825350 FEZ2 0.45 6.21 0.32 1.57e-9 Height; LUSC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg12463550 chr7:65579703 CRCP -0.52 -7.55 -0.38 4.17e-13 Aortic root size; LUSC cis rs997295 0.713 rs3784695 chr15:68002602 A/G cg08079166 chr15:68083412 MAP2K5 -0.33 -6.68 -0.34 9.93e-11 Motion sickness; LUSC cis rs7589728 1.000 rs6722069 chr2:88533151 C/T cg04511125 chr2:88470314 THNSL2 0.65 6.0 0.31 5.24e-9 Plasma clusterin levels; LUSC cis rs17401966 0.597 rs56221672 chr1:10247313 A/G cg19773385 chr1:10388646 KIF1B -0.41 -7.01 -0.36 1.34e-11 Hepatocellular carcinoma; LUSC cis rs208520 0.731 rs12206488 chr6:66999917 G/T cg07460842 chr6:66804631 NA 0.94 11.32 0.53 2.27e-25 Exhaled nitric oxide output; LUSC trans rs7824557 1.000 rs2736371 chr8:11105529 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.28 -0.41 2.9e-15 Retinal vascular caliber; LUSC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg14440974 chr22:39074834 NA -0.4 -6.54 -0.34 2.25e-10 Menopause (age at onset); LUSC trans rs62103177 0.525 rs8086024 chr18:77746623 A/G cg14227996 chr4:17616232 MED28 -0.55 -6.39 -0.33 5.69e-10 Opioid sensitivity; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.68 -10.28 -0.49 1.03e-21 Lymphocyte counts; LUSC cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg13010199 chr12:38710504 ALG10B 0.69 11.65 0.54 1.5e-26 Heart rate; LUSC cis rs868036 0.681 rs4776375 chr15:68085555 G/A cg08079166 chr15:68083412 MAP2K5 0.41 7.43 0.38 9.02e-13 Restless legs syndrome; LUSC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg22875332 chr1:76189707 ACADM 0.84 14.89 0.63 7.84e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7267979 0.966 rs2261747 chr20:25261784 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.24 0.74 5.15e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.16e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg21433313 chr16:3507492 NAT15 -0.68 -11.34 -0.53 2.03e-25 Tuberculosis; LUSC cis rs12908161 1.000 rs58416181 chr15:85264461 G/A cg11189052 chr15:85197271 WDR73 0.48 5.92 0.31 7.86e-9 Schizophrenia; LUSC cis rs12458462 0.859 rs34242155 chr18:77425192 G/A cg20476159 chr18:77451067 CTDP1 -0.33 -5.86 -0.31 1.09e-8 Monocyte count; LUSC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg13047869 chr3:10149882 C3orf24 0.56 7.73 0.39 1.24e-13 Alzheimer's disease; LUSC cis rs79349575 0.777 rs28517720 chr17:46976756 C/G cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg07701084 chr6:150067640 NUP43 0.46 6.71 0.34 8.46e-11 Lung cancer; LUSC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg15445000 chr17:37608096 MED1 -0.4 -6.81 -0.35 4.56e-11 Glomerular filtration rate (creatinine); LUSC cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg16339924 chr4:17578868 LAP3 0.5 7.35 0.37 1.54e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs35883536 0.647 rs10493929 chr1:101043928 A/C cg09408571 chr1:101003634 GPR88 -0.29 -5.71 -0.3 2.51e-8 Monocyte count; LUSC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.08 -0.48 4.83e-21 Obesity-related traits; LUSC cis rs1577917 0.958 rs34795473 chr6:86461799 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.89 -0.35 2.78e-11 Response to antipsychotic treatment; LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC trans rs35110281 0.712 rs8133523 chr21:45062403 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 12.24 0.56 1.06e-28 Mean corpuscular volume; LUSC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg13395646 chr4:1353034 KIAA1530 -0.54 -8.19 -0.41 5.49e-15 Obesity-related traits; LUSC cis rs7119 0.717 rs11630916 chr15:77821331 G/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.51 -0.34 2.69e-10 Type 2 diabetes; LUSC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg15556689 chr8:8085844 FLJ10661 -0.69 -11.77 -0.54 5.53e-27 Mood instability; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg10729496 chr3:10149963 C3orf24 0.52 6.88 0.35 2.9100000000000002e-11 Alzheimer's disease; LUSC cis rs68170813 0.559 rs76307631 chr7:107058018 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.21 -0.45 3.73e-18 Coronary artery disease; LUSC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.13e-9 Developmental language disorder (linguistic errors); LUSC cis rs921968 0.643 rs612874 chr2:219492924 T/C cg02176678 chr2:219576539 TTLL4 0.6 10.84 0.51 1.18e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs11690935 0.959 rs2674484 chr2:172574612 G/A cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.75 -0.63 2.9e-38 Schizophrenia; LUSC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg26597838 chr10:835615 NA 1.24 16.51 0.67 3.35e-45 Eosinophil percentage of granulocytes; LUSC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.62 -0.38 2.7e-13 Developmental language disorder (linguistic errors); LUSC cis rs1775715 0.870 rs1251407 chr10:32238325 A/G cg03015672 chr10:32216066 ARHGAP12 0.33 5.86 0.31 1.09e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7495132 0.563 rs4404048 chr15:91196423 T/C cg05609160 chr15:91208370 NA -0.4 -5.65 -0.3 3.48e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC trans rs9393777 0.720 rs34864993 chr6:26970895 C/A cg06606381 chr12:133084897 FBRSL1 -0.61 -6.33 -0.33 8.07e-10 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18019004 chr20:3209307 SLC4A11 0.52 7.6 0.38 2.97e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4942242 1.000 rs7335094 chr13:44223936 T/C cg19169023 chr15:41853346 TYRO3 -0.45 -7.27 -0.37 2.63e-12 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg03929089 chr4:120376271 NA 0.79 10.08 0.48 5.01e-21 Coronary artery disease; LUSC cis rs950169 0.840 rs62019457 chr15:85102142 T/C cg12863693 chr15:85201151 NMB 0.36 7.22 0.37 3.54e-12 Schizophrenia; LUSC cis rs6987853 0.749 rs13250124 chr8:42404737 G/A cg09913449 chr8:42400586 C8orf40 0.53 9.22 0.45 3.48e-18 Mean corpuscular hemoglobin concentration; LUSC trans rs11098499 0.954 rs67265404 chr4:120359270 C/T cg25214090 chr10:38739885 LOC399744 0.56 8.2 0.41 5.25e-15 Corneal astigmatism; LUSC cis rs35094601 0.731 rs4954928 chr2:139212763 G/T cg10095539 chr2:139258744 SPOPL 0.25 5.86 0.31 1.13e-8 Schizophrenia; LUSC cis rs4969178 0.965 rs11653305 chr17:76386918 T/C cg05887092 chr17:76393375 PGS1 0.51 9.01 0.44 1.61e-17 HDL cholesterol levels; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg03790207 chr6:42947109 PEX6 -0.44 -6.59 -0.34 1.67e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7113850 0.541 rs56732861 chr11:24234333 C/G ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Bone fracture in osteoporosis; LUSC trans rs1728785 0.818 rs1645984 chr16:68628850 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 7.84 0.39 6.24e-14 Ulcerative colitis; LUSC trans rs7944735 0.545 rs4752805 chr11:48018355 A/G cg15704280 chr7:45808275 SEPT13 0.57 6.66 0.34 1.14e-10 Intraocular pressure; LUSC cis rs12210905 0.925 rs10456349 chr6:26975459 G/A cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs71403859 0.502 rs8053720 chr16:71456142 C/G cg08717414 chr16:71523259 ZNF19 -0.63 -7.41 -0.38 1.02e-12 Post bronchodilator FEV1; LUSC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.16 -0.36 5.24e-12 Major depressive disorder; LUSC cis rs929596 0.561 rs6431625 chr2:234637912 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.53 -8.9 -0.44 3.64e-17 Total bilirubin levels in HIV-1 infection; LUSC trans rs2204008 0.659 rs4002655 chr12:38169881 T/G cg06521331 chr12:34319734 NA -0.39 -6.12 -0.32 2.68e-9 Bladder cancer; LUSC cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.75 -0.51 2.37e-23 Alzheimer's disease (late onset); LUSC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg03526776 chr6:41159608 TREML2 0.34 6.53 0.34 2.51e-10 Alzheimer's disease (late onset); LUSC cis rs612683 0.536 rs1335753 chr1:101027157 G/T cg06223162 chr1:101003688 GPR88 0.53 9.93 0.48 1.59e-20 Breast cancer; LUSC cis rs9287719 0.556 rs10168351 chr2:10736810 T/C cg00105475 chr2:10696890 NA 0.34 5.75 0.3 1.98e-8 Prostate cancer; LUSC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg14440974 chr22:39074834 NA -0.36 -6.0 -0.31 5.18e-9 Menopause (age at onset); LUSC cis rs7605827 0.860 rs13425097 chr2:15528920 C/G cg19274914 chr2:15703543 NA 0.46 8.94 0.44 2.79e-17 Educational attainment (years of education); LUSC cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.08 -0.36 8.41e-12 Menopause (age at onset); LUSC cis rs10216189 0.967 rs4724700 chr7:5526789 A/G cg11800390 chr7:5515995 FBXL18 0.33 7.32 0.37 1.85e-12 Relative hand skill in reading disability; LUSC cis rs77741769 0.571 rs11611087 chr12:121267126 C/T cg02419362 chr12:121203948 SPPL3 0.45 8.36 0.42 1.66e-15 Mean corpuscular volume; LUSC cis rs7216064 1.000 rs4271626 chr17:65930133 G/A cg12091567 chr17:66097778 LOC651250 -0.71 -9.45 -0.46 6.25e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg23711669 chr6:146136114 FBXO30 0.85 15.8 0.65 2.19e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.967 rs365515 chr6:145802833 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.46 -0.56 1.61e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs10876993 0.826 rs1678534 chr12:58057435 A/C cg18357645 chr12:58087776 OS9 0.52 7.86 0.4 5.41e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs62458065 0.850 rs7808992 chr7:32470677 C/T cg20159608 chr7:32802032 NA -0.68 -8.09 -0.4 1.1e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs12618769 0.597 rs3769743 chr2:99063653 C/T cg10123293 chr2:99228465 UNC50 0.45 7.64 0.39 2.31e-13 Bipolar disorder; LUSC cis rs2635047 1.000 rs2684826 chr18:44679147 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.72 0.35 7.9e-11 Educational attainment; LUSC cis rs10761482 0.544 rs1938544 chr10:62284659 C/G cg18175470 chr10:62150864 ANK3 -0.51 -7.4 -0.38 1.12e-12 Schizophrenia; LUSC cis rs500891 0.525 rs13192260 chr6:84110729 T/C cg08257003 chr6:84140564 ME1 0.33 7.36 0.37 1.4e-12 Platelet-derived growth factor BB levels; LUSC cis rs6430585 0.583 rs2304370 chr2:136561735 G/A cg07169764 chr2:136633963 MCM6 0.98 13.72 0.6 2.83e-34 Corneal structure; LUSC cis rs7615952 0.673 rs3811677 chr3:125648080 G/A cg05084668 chr3:125655381 ALG1L -0.79 -11.9 -0.55 1.87e-27 Blood pressure (smoking interaction); LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.1 0.41 1.07e-14 Bipolar disorder; LUSC cis rs8044995 0.636 rs117761434 chr16:68254196 G/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.02 -0.36 1.24e-11 Schizophrenia; LUSC cis rs13089785 1.000 rs2332682 chr3:123654633 C/T cg01860459 chr3:123419554 MYLK 0.35 6.14 0.32 2.33e-9 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg00990874 chr7:1149470 C7orf50 -0.61 -8.15 -0.41 7.3e-15 Bronchopulmonary dysplasia; LUSC cis rs861020 0.771 rs654470 chr1:210014093 A/T cg09163369 chr1:210001066 C1orf107 0.58 6.87 0.35 3.15e-11 Orofacial clefts; LUSC trans rs1499614 1.000 rs2707838 chr7:66159201 C/T cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs9323205 0.954 rs7150336 chr14:51584596 A/T cg23942311 chr14:51606299 NA -0.43 -8.32 -0.41 2.22e-15 Cancer; LUSC cis rs72634258 0.732 rs6577464 chr1:8171302 T/C cg00042356 chr1:8021962 PARK7 -0.55 -6.56 -0.34 1.99e-10 Inflammatory bowel disease; LUSC cis rs644799 0.710 rs523153 chr11:95570961 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.81 13.36 0.59 6.54e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg18225595 chr11:63971243 STIP1 0.52 6.54 0.34 2.38e-10 Mean platelet volume; LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg18758796 chr5:131593413 PDLIM4 -0.37 -6.19 -0.32 1.74e-9 Breast cancer; LUSC cis rs17685 0.753 rs2108274 chr7:75781636 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.88 -0.4 4.64e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg16405210 chr4:1374714 KIAA1530 -0.53 -7.89 -0.4 4.44e-14 Obesity-related traits; LUSC cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg18876405 chr7:65276391 NA 0.55 8.65 0.43 2.22e-16 Aortic root size; LUSC cis rs11039100 0.850 rs34286221 chr11:5834852 G/T cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1062746 0.528 rs11646030 chr16:87339278 T/C cg02258303 chr16:87377426 FBXO31 -0.53 -8.07 -0.4 1.24e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs208520 1.000 rs12194996 chr6:66973366 G/C cg07460842 chr6:66804631 NA 0.95 12.04 0.55 5.59e-28 Exhaled nitric oxide output; LUSC cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs7523273 0.606 rs2796268 chr1:207925192 G/A cg22525895 chr1:207977042 MIR29B2 0.4 6.36 0.33 6.81e-10 Schizophrenia; LUSC cis rs1348850 0.958 rs10930801 chr2:178459861 G/A cg22681709 chr2:178499509 PDE11A -0.46 -8.44 -0.42 9.71e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10979 0.557 rs9390116 chr6:143907577 A/G cg25407410 chr6:143891975 LOC285740 -0.65 -8.19 -0.41 5.6e-15 Hypospadias; LUSC cis rs7428 0.539 rs4247303 chr2:85554080 G/A cg24342717 chr2:85555507 TGOLN2 -0.71 -11.01 -0.52 3.01e-24 Ear protrusion; LUSC trans rs11098499 0.644 rs6855918 chr4:120546299 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.49 0.33 3.18e-10 Corneal astigmatism; LUSC cis rs7075426 0.753 rs11202040 chr10:88208199 C/T cg07322936 chr10:88137208 NA -0.46 -6.72 -0.35 7.88e-11 Migraine without aura; LUSC cis rs1982963 1.000 rs10139288 chr14:52506486 T/C cg10843707 chr14:52510701 NID2 -0.4 -6.45 -0.33 3.99e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg02018176 chr4:1364513 KIAA1530 -0.57 -9.89 -0.48 2.17e-20 Obesity-related traits; LUSC cis rs2295359 0.892 rs2064689 chr1:67653010 G/A cg12940439 chr1:67600707 NA 0.37 6.02 0.31 4.51e-9 Psoriasis; LUSC cis rs13082711 0.911 rs34878935 chr3:27466123 A/C cg02860705 chr3:27208620 NA 0.52 8.71 0.43 1.44e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7267979 1.000 rs6083844 chr20:25386832 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.66 -0.73 1.02e-57 Liver enzyme levels (alkaline phosphatase); LUSC trans rs804280 0.509 rs4841639 chr8:11796093 A/T cg08975724 chr8:8085496 FLJ10661 0.48 6.91 0.35 2.49e-11 Myopia (pathological); LUSC trans rs2262909 0.962 rs411020 chr19:22231102 G/A cg17074339 chr11:11642133 GALNTL4 -0.46 -7.07 -0.36 9.1e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs12310956 0.532 rs1352210 chr12:33983187 A/G cg06521331 chr12:34319734 NA -0.44 -7.18 -0.37 4.6e-12 Morning vs. evening chronotype; LUSC trans rs3857536 0.813 rs6455090 chr6:66948909 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.05 -0.31 3.84e-9 Blood trace element (Cu levels); LUSC cis rs11039100 0.850 rs35990969 chr11:5834242 G/A cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.59 -0.34 1.73e-10 High light scatter reticulocyte count; LUSC cis rs2242663 0.705 rs551708 chr11:66486143 T/C cg24851651 chr11:66362959 CCS -0.37 -5.92 -0.31 7.81e-9 Bipolar disorder; LUSC cis rs76878669 0.561 rs1784029 chr11:66099987 C/T cg24851651 chr11:66362959 CCS -0.38 -6.19 -0.32 1.77e-9 Educational attainment (years of education); LUSC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg08859206 chr1:53392774 SCP2 -0.55 -9.61 -0.47 1.81e-19 Monocyte count; LUSC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.78 -0.35 5.36e-11 Monocyte percentage of white cells; LUSC cis rs12519773 0.597 rs17360518 chr5:92457899 A/C cg18783429 chr5:92414398 NA 0.35 7.39 0.37 1.22e-12 Migraine; LUSC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg13395646 chr4:1353034 KIAA1530 -0.56 -8.36 -0.42 1.66e-15 Obesity-related traits; LUSC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg13206674 chr6:150067644 NUP43 0.6 9.63 0.47 1.59e-19 Lung cancer; LUSC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg08392591 chr16:89556376 ANKRD11 0.43 6.43 0.33 4.34e-10 Multiple myeloma (IgH translocation); LUSC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.33 0.53 2.12e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg25456477 chr12:86230367 RASSF9 -0.32 -5.69 -0.3 2.83e-8 Major depressive disorder; LUSC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs7106204 0.688 rs7131103 chr11:24219299 A/G ch.11.24196551F chr11:24239977 NA 0.95 9.06 0.44 1.12e-17 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC trans rs11039798 0.588 rs10437592 chr11:48598859 G/T cg03929089 chr4:120376271 NA 0.61 6.58 0.34 1.78e-10 Axial length; LUSC cis rs6546550 0.901 rs6754896 chr2:70138170 T/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg01802117 chr1:53393560 SCP2 0.38 6.41 0.33 5.01e-10 Monocyte count; LUSC trans rs6502050 0.805 rs11651863 chr17:80084539 T/C cg07393940 chr7:158741817 NA -0.37 -6.61 -0.34 1.55e-10 Life satisfaction; LUSC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg27170947 chr2:26402098 FAM59B -0.64 -9.43 -0.46 7.05e-19 Gut microbiome composition (summer); LUSC cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg18681998 chr4:17616180 MED28 -0.88 -15.48 -0.65 3.97e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg18099408 chr3:52552593 STAB1 -0.41 -6.95 -0.36 1.92e-11 Bipolar disorder; LUSC cis rs11098499 0.954 rs878373 chr4:120237484 A/T cg24375607 chr4:120327624 NA 0.8 11.97 0.55 1.04e-27 Corneal astigmatism; LUSC cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg00857998 chr1:205179979 DSTYK 0.59 8.86 0.44 4.91e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg20887711 chr4:1340912 KIAA1530 0.47 7.29 0.37 2.27e-12 Obesity-related traits; LUSC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg07936489 chr17:37558343 FBXL20 -0.73 -9.98 -0.48 1.02e-20 Glomerular filtration rate (creatinine); LUSC cis rs10791323 0.572 rs10894755 chr11:133739685 C/T cg15485101 chr11:133734466 NA -0.37 -6.57 -0.34 1.99e-10 Childhood ear infection; LUSC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg20821713 chr7:1055600 C7orf50 -0.5 -6.62 -0.34 1.46e-10 Bronchopulmonary dysplasia; LUSC cis rs9399135 0.967 rs4896125 chr6:135342569 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.28 0.45 2.26e-18 Red blood cell count; LUSC cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.47 -0.33 3.55e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg00999904 chr2:3704751 ALLC 0.44 7.75 0.39 1.13e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs3849570 0.961 rs13340130 chr3:81790970 A/T cg07356753 chr3:81810745 GBE1 -0.69 -11.29 -0.53 2.99e-25 Waist circumference;Body mass index; LUSC trans rs9545047 0.604 rs1324868 chr13:79954175 A/G cg00747290 chr2:42721154 KCNG3 -0.62 -6.83 -0.35 4.14e-11 Schizophrenia; LUSC cis rs4820539 1.000 rs6003518 chr22:23471533 C/T cg14186256 chr22:23484241 RTDR1 0.94 17.82 0.7 2.22e-50 Bone mineral density; LUSC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg08270630 chr22:50330655 NA -0.39 -5.82 -0.3 1.41e-8 Schizophrenia; LUSC cis rs16937 0.618 rs6659069 chr1:205182031 A/G cg21643547 chr1:205240462 TMCC2 -0.35 -6.16 -0.32 2.15e-9 Schizophrenia; LUSC cis rs9815354 0.904 rs73073368 chr3:41843391 A/G cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7759001 0.817 rs6456779 chr6:27370473 T/C cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC cis rs5758659 0.652 rs133305 chr22:42395960 C/T cg04733989 chr22:42467013 NAGA 0.39 6.54 0.34 2.32e-10 Cognitive function; LUSC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg09323728 chr8:95962352 TP53INP1 -0.37 -7.34 -0.37 1.63e-12 Type 2 diabetes; LUSC trans rs7824557 0.628 rs2572387 chr8:11204165 C/T cg08975724 chr8:8085496 FLJ10661 0.44 6.27 0.32 1.14e-9 Retinal vascular caliber; LUSC cis rs9322817 0.691 rs2400072 chr6:105344116 C/T cg02098413 chr6:105308735 HACE1 0.28 5.96 0.31 6.43e-9 Thyroid stimulating hormone; LUSC cis rs6500602 0.727 rs7193136 chr16:4580034 C/T cg08645402 chr16:4508243 NA 0.48 7.98 0.4 2.44e-14 Schizophrenia; LUSC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg02772935 chr3:125709198 NA -0.5 -5.99 -0.31 5.3300000000000004e-09 Blood pressure (smoking interaction); LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg18404041 chr3:52824283 ITIH1 -0.6 -11.62 -0.54 1.93e-26 Bipolar disorder; LUSC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg09165964 chr15:75287851 SCAMP5 0.5 7.22 0.37 3.46e-12 Breast cancer; LUSC trans rs800082 0.867 rs2717393 chr3:144280290 T/C cg24215973 chr2:240111563 HDAC4 0.47 6.98 0.36 1.59e-11 Smoking behavior; LUSC cis rs9399135 0.967 rs4895434 chr6:135293365 G/A cg22676075 chr6:135203613 NA 0.48 7.42 0.38 9.61e-13 Red blood cell count; LUSC cis rs977987 0.835 rs3863445 chr16:75371744 C/G cg03315344 chr16:75512273 CHST6 0.53 10.0 0.48 9.13e-21 Dupuytren's disease; LUSC cis rs7914558 1.000 rs7077291 chr10:104945751 C/T cg05855489 chr10:104503620 C10orf26 0.61 9.82 0.47 3.67e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg00049323 chr5:472564 LOC25845 0.49 7.77 0.39 9.73e-14 Cystic fibrosis severity; LUSC cis rs2625529 0.823 rs11072332 chr15:72108307 G/T cg16672083 chr15:72433130 SENP8 -0.5 -7.19 -0.37 4.26e-12 Red blood cell count; LUSC cis rs362272 0.545 rs3135145 chr4:3299504 T/C cg18352616 chr4:3374830 RGS12 0.3 5.92 0.31 8.03e-9 Serum sulfate level; LUSC cis rs208520 0.690 rs7739253 chr6:66861052 A/G cg07460842 chr6:66804631 NA -1.13 -17.68 -0.7 7.6600000000000005e-50 Exhaled nitric oxide output; LUSC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg16339924 chr4:17578868 LAP3 0.59 9.12 0.45 7.13e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs28647808 0.881 rs7029256 chr9:136263655 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs9394152 0.845 rs9380367 chr6:33474975 G/A cg13560919 chr6:33536144 NA 0.6 10.77 0.51 2.06e-23 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs344364 0.602 rs2437744 chr16:1908451 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.41 5.98 0.31 5.59e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2425143 1.000 rs1056196 chr20:34327159 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.18 -0.32 1.83e-9 Blood protein levels; LUSC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg02931644 chr1:25747376 RHCE 0.37 6.86 0.35 3.32e-11 Erythrocyte sedimentation rate; LUSC cis rs58688157 0.960 rs10902178 chr11:612843 T/G cg01842473 chr11:617407 IRF7;MUPCDH -0.69 -10.09 -0.48 4.37e-21 Systemic lupus erythematosus; LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.8 10.73 0.51 2.82e-23 Alzheimer's disease; LUSC cis rs72627509 0.904 rs58408429 chr4:57769824 T/C cg26694713 chr4:57773883 REST 0.52 6.42 0.33 4.78e-10 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs9650657 0.589 rs6985109 chr8:10761585 A/G cg15556689 chr8:8085844 FLJ10661 0.58 8.35 0.42 1.88e-15 Neuroticism; LUSC cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.61 -0.6 7.34e-34 Chronic sinus infection; LUSC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg16606324 chr3:10149918 C3orf24 -0.43 -6.83 -0.35 3.93e-11 Alzheimer's disease; LUSC cis rs2731664 0.792 rs335432 chr5:176866258 G/A cg23176889 chr5:176863531 GRK6 -0.69 -14.35 -0.62 1.06e-36 Intelligence (multi-trait analysis); LUSC cis rs6504340 0.793 rs56128659 chr17:46621828 T/A cg09704116 chr17:46666958 LOC404266 -0.38 -6.41 -0.33 4.87e-10 Primary tooth development (number of teeth); LUSC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg05393297 chr12:53359155 NA -0.56 -8.58 -0.43 3.53e-16 Prostate cancer; LUSC cis rs2798269 0.902 rs10492455 chr13:22102976 A/G cg18095732 chr13:22033692 ZDHHC20 -0.39 -5.86 -0.31 1.08e-8 PR segment; LUSC cis rs4664308 0.837 rs56172865 chr2:160967333 C/T cg03641300 chr2:160917029 PLA2R1 -0.64 -10.76 -0.51 2.18e-23 Idiopathic membranous nephropathy; LUSC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg00745463 chr17:30367425 LRRC37B -0.81 -9.51 -0.46 3.78e-19 Hip circumference adjusted for BMI; LUSC cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg08213375 chr14:104286397 PPP1R13B 0.49 9.29 0.45 1.97e-18 Schizophrenia; LUSC cis rs1443512 0.812 rs1992563 chr12:54330441 G/T cg25024717 chr12:54324583 NA -0.4 -6.9 -0.35 2.69e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs6089829 0.962 rs6011544 chr20:61658782 T/C cg03213289 chr20:61660250 NA 0.66 12.81 0.57 7.61e-31 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg25767906 chr1:53392781 SCP2 0.4 6.92 0.35 2.37e-11 Monocyte count; LUSC trans rs61931739 0.513 rs1608906 chr12:33894986 T/C cg26384229 chr12:38710491 ALG10B 0.57 8.87 0.44 4.41e-17 Morning vs. evening chronotype; LUSC cis rs7605827 0.897 rs11674618 chr2:15593035 T/C cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.26e-17 Educational attainment (years of education); LUSC cis rs8077889 0.956 rs116979403 chr17:41849105 G/A cg26893861 chr17:41843967 DUSP3 0.96 14.62 0.62 9.17e-38 Triglycerides; LUSC cis rs738322 0.600 rs7286105 chr22:38557821 A/G cg25457927 chr22:38595422 NA -0.34 -6.81 -0.35 4.62e-11 Cutaneous nevi; LUSC cis rs72634258 0.679 rs7523227 chr1:8180097 G/A cg00042356 chr1:8021962 PARK7 0.54 6.59 0.34 1.72e-10 Inflammatory bowel disease; LUSC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg21573476 chr21:45109991 RRP1B -0.37 -5.92 -0.31 7.93e-9 Mean corpuscular volume; LUSC cis rs2439831 0.867 rs486301 chr15:43836949 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.83 9.23 0.45 3.08e-18 Lung cancer in ever smokers; LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg07703079 chr11:430292 ANO9 0.6 6.56 0.34 2.03e-10 Body mass index; LUSC cis rs9303542 0.625 rs62065846 chr17:46592858 G/A cg09704116 chr17:46666958 LOC404266 -0.36 -6.73 -0.35 7.56e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs796364 0.616 rs2030653 chr2:200677625 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.97 0.31 6.22e-9 Schizophrenia; LUSC cis rs11190604 1.000 rs2295776 chr10:102295629 G/T cg23241863 chr10:102295624 HIF1AN 0.48 5.91 0.31 8.26e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg20607798 chr8:58055168 NA 0.49 5.84 0.3 1.24e-8 Developmental language disorder (linguistic errors); LUSC cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg06552810 chr11:31128660 NA -0.42 -7.34 -0.37 1.61e-12 Red blood cell count; LUSC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.76 11.03 0.52 2.57e-24 Cognitive test performance; LUSC trans rs10432169 1 rs10432169 chr18:31347098 C/G cg27147174 chr7:100797783 AP1S1 -0.46 -6.68 -0.34 1.01e-10 Subjective well-being; LUSC trans rs61931739 0.534 rs814669 chr12:34102459 C/T cg13010199 chr12:38710504 ALG10B 0.54 8.05 0.4 1.48e-14 Morning vs. evening chronotype; LUSC cis rs4343996 0.902 rs4521670 chr7:3383603 C/T cg21248987 chr7:3385318 SDK1 0.41 7.03 0.36 1.15e-11 Motion sickness; LUSC trans rs1728785 0.688 rs698729 chr16:68624205 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.69 0.39 1.67e-13 Ulcerative colitis; LUSC cis rs7917772 0.546 rs10883743 chr10:104338389 T/C cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg00431813 chr7:1051703 C7orf50 -0.47 -7.85 -0.39 5.58e-14 Longevity;Endometriosis; LUSC trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg17830980 chr10:43048298 ZNF37B -0.57 -9.31 -0.45 1.82e-18 Extrinsic epigenetic age acceleration; LUSC cis rs941408 0.928 rs2260414 chr19:2796316 G/A cg06609049 chr19:2785107 THOP1 0.7 11.07 0.52 1.78e-24 Total cholesterol levels; LUSC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.875 rs2777479 chr6:146309178 C/A cg05347473 chr6:146136440 FBXO30 0.51 8.42 0.42 1.13e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.12 0.32 2.57e-9 Systolic blood pressure; LUSC cis rs1045714 0.895 rs73043180 chr7:2645972 C/T cg24848437 chr7:2645542 IQCE 0.61 6.74 0.35 6.84e-11 Urate levels in lean individuals; LUSC cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg12011299 chr4:100065546 ADH4 0.68 11.35 0.53 1.79e-25 Alcohol dependence; LUSC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg06481639 chr22:41940642 POLR3H -0.53 -5.98 -0.31 5.59e-9 Vitiligo; LUSC cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.61 0.38 2.82e-13 Menarche (age at onset); LUSC cis rs9914988 0.832 rs35033748 chr17:27179590 T/C cg09479241 chr17:27052676 TLCD1 0.44 6.23 0.32 1.39e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1215050 0.874 rs17545594 chr4:98652689 A/G cg05340658 chr4:99064831 C4orf37 -0.42 -6.49 -0.33 3.09e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7223966 1.000 rs7214312 chr17:61870863 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.9 0.35 2.56e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg04727924 chr7:799746 HEATR2 -0.57 -5.91 -0.31 8.66e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg14784868 chr12:69753453 YEATS4 0.79 13.66 0.6 4.69e-34 Blood protein levels; LUSC cis rs16854884 0.657 rs35067746 chr3:143747147 T/A cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs7829975 0.577 rs7816329 chr8:8543843 G/A cg15556689 chr8:8085844 FLJ10661 -0.5 -7.31 -0.37 1.96e-12 Mood instability; LUSC cis rs4891159 0.790 rs17059379 chr18:74160316 A/T cg24786174 chr18:74118243 ZNF516 0.8 15.01 0.63 2.67e-39 Longevity; LUSC trans rs61931739 0.500 rs10844734 chr12:34043083 G/A cg13010199 chr12:38710504 ALG10B 0.53 7.92 0.4 3.45e-14 Morning vs. evening chronotype; LUSC cis rs75804782 0.580 rs72987332 chr2:239362529 G/T cg18131467 chr2:239335373 ASB1 -0.74 -6.67 -0.34 1.06e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs5756813 0.727 rs4239889 chr22:38140352 T/G cg06521852 chr22:38141419 TRIOBP 0.42 6.29 0.33 1.01e-9 Optic cup area;Vertical cup-disc ratio; LUSC cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg13010199 chr12:38710504 ALG10B 0.66 10.05 0.48 6.31e-21 Bladder cancer; LUSC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg09323728 chr8:95962352 TP53INP1 -0.39 -7.96 -0.4 2.65e-14 Type 2 diabetes; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg21702128 chr5:142784721 NR3C1 0.48 6.4 0.33 5.37e-10 Cognitive function;Information processing speed; LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs354225 0.544 rs11892443 chr2:54805776 A/G cg26097391 chr2:54893211 SPTBN1 0.46 6.95 0.36 1.88e-11 Schizophrenia; LUSC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg13206674 chr6:150067644 NUP43 0.61 9.78 0.47 4.8e-20 Lung cancer; LUSC cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg17420585 chr12:42539391 GXYLT1 -0.39 -7.65 -0.39 2.19e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs3824867 0.920 rs10742805 chr11:47454701 A/G cg20307385 chr11:47447363 PSMC3 0.65 9.74 0.47 6.75e-20 Mean corpuscular hemoglobin; LUSC cis rs4851254 0.618 rs4851243 chr2:100639482 G/A cg07810366 chr2:100720526 AFF3 -0.47 -6.04 -0.31 4e-9 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.955 rs1397608 chr4:120161744 A/G cg09307838 chr4:120376055 NA 0.71 10.32 0.49 7.35e-22 Corneal astigmatism; LUSC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg12310025 chr6:25882481 NA -0.62 -10.43 -0.5 3.2e-22 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg24846343 chr22:24311635 DDTL 0.56 11.32 0.53 2.27e-25 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg00012203 chr2:219082015 ARPC2 -0.56 -8.89 -0.44 3.81e-17 Ulcerative colitis; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg06873352 chr17:61820015 STRADA 0.71 12.8 0.57 8.38e-31 Prudent dietary pattern; LUSC cis rs4953318 0.694 rs3768747 chr2:46352058 G/T cg12428440 chr2:46370979 PRKCE -0.42 -7.69 -0.39 1.67e-13 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg18512352 chr11:47633146 NA 0.47 9.59 0.46 2.21e-19 Subjective well-being; LUSC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg17376030 chr22:41985996 PMM1 -0.46 -5.73 -0.3 2.3e-8 Vitiligo; LUSC trans rs62055045 0.656 rs112777805 chr16:71425165 G/C cg15281710 chr15:96890452 NA -0.43 -5.95 -0.31 6.93e-9 Schizophrenia; LUSC cis rs10911232 0.507 rs11582514 chr1:182992161 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.54 0.5 1.34e-22 Hypertriglyceridemia; LUSC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.54 0.38 4.41e-13 Cognitive function; LUSC cis rs10992471 0.603 rs6479422 chr9:95190694 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.46 -7.95 -0.4 2.9e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs656319 0.559 rs60384372 chr8:9974584 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.8 -0.35 4.9e-11 Myopia (pathological); LUSC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg03161606 chr19:29218774 NA 0.6 8.75 0.43 1.08e-16 Methadone dose in opioid dependence; LUSC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg14829155 chr15:31115871 NA -0.56 -7.83 -0.39 6.49e-14 Huntington's disease progression; LUSC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg25767906 chr1:53392781 SCP2 -0.55 -10.73 -0.51 2.88e-23 Monocyte count; LUSC cis rs12200782 1.000 rs4292511 chr6:26622290 G/T cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs2455601 0.638 rs2742478 chr11:8996099 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -6.7 -0.34 9.05e-11 Schizophrenia; LUSC cis rs6840360 0.571 rs11939356 chr4:152505234 G/C cg22705602 chr4:152727874 NA -0.32 -6.37 -0.33 6.11e-10 Intelligence (multi-trait analysis); LUSC cis rs9650657 0.504 rs10093053 chr8:11037187 T/C cg27411982 chr8:10470053 RP1L1 -0.41 -6.27 -0.32 1.14e-9 Neuroticism; LUSC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg20476274 chr7:133979776 SLC35B4 0.84 15.3 0.64 1.96e-40 Mean platelet volume; LUSC cis rs17092148 1.000 rs6058117 chr20:33366905 A/G cg16810054 chr20:33298113 TP53INP2 -0.43 -6.81 -0.35 4.68e-11 Neuroticism; LUSC cis rs4268898 0.679 rs2551181 chr2:24437548 C/T cg06627628 chr2:24431161 ITSN2 0.84 12.5 0.56 1.12e-29 Asthma; LUSC cis rs2742417 0.603 rs1962800 chr3:45779943 C/T cg10512202 chr3:45649293 LIMD1 0.34 5.85 0.3 1.18e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg05623727 chr3:50126028 RBM5 -0.33 -6.17 -0.32 2.02e-9 Body mass index; LUSC cis rs4746818 0.793 rs2805913 chr10:70858062 A/G cg11621586 chr10:70884670 VPS26A 0.87 10.87 0.51 9.1e-24 Left atrial antero-posterior diameter; LUSC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg22800045 chr5:56110881 MAP3K1 -0.65 -9.04 -0.44 1.27e-17 Initial pursuit acceleration; LUSC cis rs6545883 0.929 rs1186710 chr2:61688727 T/A cg15711740 chr2:61764176 XPO1 -0.44 -6.66 -0.34 1.11e-10 Tuberculosis; LUSC cis rs1348850 0.914 rs1374437 chr2:178363423 T/C cg22681709 chr2:178499509 PDE11A -0.48 -8.86 -0.44 4.69e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9487051 0.768 rs386696 chr6:109520166 G/A cg00509249 chr6:109615579 CCDC162 -0.34 -5.88 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs62400317 0.826 rs11970496 chr6:45125833 A/G cg18551225 chr6:44695536 NA -0.42 -6.89 -0.35 2.76e-11 Total body bone mineral density; LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg08888203 chr3:10149979 C3orf24 0.61 8.36 0.42 1.68e-15 Alzheimer's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03425468 chr1:155164676 MIR92B -0.48 -6.37 -0.33 6.28e-10 Bipolar disorder and schizophrenia; LUSC cis rs2224391 0.628 rs2773313 chr6:5252213 C/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.48 -6.73 -0.35 7.62e-11 Height; LUSC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.31 0.33 8.63e-10 Personality dimensions; LUSC cis rs7577696 0.814 rs479333 chr2:32489158 C/G cg02381751 chr2:32503542 YIPF4 -0.39 -5.84 -0.3 1.21e-8 Inflammatory biomarkers; LUSC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg06008330 chr7:65541103 ASL -0.4 -6.22 -0.32 1.49e-9 Aortic root size; LUSC cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs2273669 0.504 rs79374607 chr6:109398257 C/T cg05315195 chr6:109294784 ARMC2 -0.56 -5.91 -0.31 8.4e-9 Prostate cancer; LUSC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.42 5.88 0.31 9.8e-9 Height; LUSC cis rs672059 1.000 rs625917 chr1:183157991 T/G ch.1.3577855R chr1:183094577 LAMC1 0.55 7.98 0.4 2.31e-14 Hypertriglyceridemia; LUSC cis rs738322 0.600 rs4821751 chr22:38564457 T/C cg25457927 chr22:38595422 NA -0.38 -7.51 -0.38 5.39e-13 Cutaneous nevi; LUSC cis rs2281845 0.826 rs4915484 chr1:201076917 C/G cg22815214 chr1:201083145 CACNA1S 0.54 9.39 0.46 9.49e-19 Permanent tooth development; LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg27081603 chr5:175788876 KIAA1191 0.4 6.31 0.33 9.02e-10 Major depressive disorder; LUSC cis rs61990749 0.597 rs1477262 chr14:78226653 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.62 6.58 0.34 1.78e-10 Fibroblast growth factor basic levels; LUSC cis rs921968 0.541 rs3821031 chr2:219295249 C/T cg02176678 chr2:219576539 TTLL4 -0.72 -13.35 -0.59 7.3e-33 Mean corpuscular hemoglobin concentration; LUSC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg14019146 chr3:50243930 SLC38A3 0.36 8.23 0.41 4.28e-15 Body mass index; LUSC cis rs1371867 0.839 rs1788186 chr8:101335686 T/C cg00191853 chr8:101177733 SPAG1 -0.39 -6.47 -0.33 3.49e-10 Atrioventricular conduction; LUSC cis rs6912958 0.500 rs4706287 chr6:87806496 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.54 -10.3 -0.49 8.79e-22 Monocyte percentage of white cells; LUSC trans rs10435719 0.773 rs7842810 chr8:11794163 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.7e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs36093844 0.948 rs56271770 chr11:85548400 C/T cg25872744 chr11:85566296 CCDC83 -0.46 -6.68 -0.34 9.92e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC trans rs561341 0.689 rs578635 chr17:30289897 A/C cg20587970 chr11:113659929 NA -0.62 -8.34 -0.42 2.01e-15 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg22535103 chr8:58192502 C8orf71 -0.67 -7.57 -0.38 3.68e-13 Developmental language disorder (linguistic errors); LUSC cis rs7072216 0.763 rs3750601 chr10:100174561 C/A cg26618903 chr10:100175079 PYROXD2 -0.48 -9.05 -0.44 1.17e-17 Metabolite levels; LUSC trans rs208520 0.545 rs6899712 chr6:66749670 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.13 20.88 0.75 1.5e-62 Exhaled nitric oxide output; LUSC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg12311346 chr5:56204834 C5orf35 0.84 13.41 0.59 4.26e-33 Initial pursuit acceleration; LUSC cis rs7927592 0.913 rs3824850 chr11:68341873 A/G cg16797656 chr11:68205561 LRP5 0.38 6.2 0.32 1.62e-9 Total body bone mineral density; LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg11645453 chr3:52864694 ITIH4 0.34 7.68 0.39 1.76e-13 Bipolar disorder; LUSC cis rs55665837 1.000 rs7945167 chr11:14451820 T/G cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 7.25e-13 Vitamin D levels; LUSC cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg00530320 chr1:46809349 NSUN4 0.56 8.67 0.43 1.91e-16 Menopause (age at onset); LUSC cis rs6964587 0.967 rs34574955 chr7:91847550 A/C cg17063962 chr7:91808500 NA 0.58 8.93 0.44 2.97e-17 Breast cancer; LUSC cis rs11122272 0.667 rs2244992 chr1:231537220 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.92 -0.48 1.7e-20 Hemoglobin concentration; LUSC cis rs11677416 1.000 rs6542092 chr2:113528322 C/G cg27083787 chr2:113543245 IL1A 0.44 6.97 0.36 1.65e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg22924838 chr2:200715629 NA 0.49 5.99 0.31 5.31e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs2274273 0.967 rs2094102 chr14:55591098 T/C cg04306507 chr14:55594613 LGALS3 0.55 12.71 0.57 1.79e-30 Protein biomarker; LUSC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg06363034 chr20:62225388 GMEB2 -0.45 -7.71 -0.39 1.47e-13 Glioblastoma; LUSC cis rs6964587 0.626 rs68009402 chr7:91516226 G/A cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg14552801 chr7:65878734 NA 0.38 5.88 0.31 9.94e-9 Aortic root size; LUSC cis rs6121246 0.909 rs4518038 chr20:30419051 A/G cg21427119 chr20:30132790 HM13 -0.42 -6.12 -0.32 2.69e-9 Mean corpuscular hemoglobin; LUSC cis rs7296418 0.699 rs11608297 chr12:123826642 T/C cg00376283 chr12:123451042 ABCB9 0.71 10.93 0.51 5.64e-24 Platelet count; LUSC cis rs1904096 0.506 rs4558832 chr4:95148042 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.37 -0.42 1.57e-15 Type 2 diabetes; LUSC cis rs10465746 0.780 rs7550413 chr1:84423891 T/A cg10977910 chr1:84465055 TTLL7 0.45 6.51 0.34 2.77e-10 Obesity-related traits; LUSC trans rs61931739 0.929 rs2389272 chr12:34067771 T/C cg13010199 chr12:38710504 ALG10B -0.47 -7.43 -0.38 8.88e-13 Morning vs. evening chronotype; LUSC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg10360139 chr7:1886902 MAD1L1 -0.46 -7.21 -0.37 3.66e-12 Bipolar disorder and schizophrenia; LUSC trans rs1908814 0.516 rs11996277 chr8:11800031 G/A cg27411982 chr8:10470053 RP1L1 0.41 6.29 0.33 1.02e-9 Neuroticism; LUSC cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg22782873 chr19:19639568 YJEFN3 0.49 6.17 0.32 2e-9 Bipolar disorder; LUSC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg18404041 chr3:52824283 ITIH1 -0.53 -10.19 -0.49 2.08e-21 Bipolar disorder; LUSC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg21782813 chr7:2030301 MAD1L1 0.35 5.79 0.3 1.61e-8 Schizophrenia; LUSC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg15147215 chr3:52552868 STAB1 -0.3 -5.98 -0.31 5.71e-9 Electroencephalogram traits; LUSC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg05043794 chr9:111880884 C9orf5 -0.33 -7.04 -0.36 1.13e-11 Menarche (age at onset); LUSC cis rs2298450 1.000 rs2298450 chr21:37623447 C/T cg02919814 chr21:37666008 DOPEY2 -0.43 -6.33 -0.33 8.11e-10 Schizophrenia; LUSC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg18306943 chr3:40428807 ENTPD3 0.37 5.67 0.3 3.12e-8 Renal cell carcinoma; LUSC cis rs478304 0.651 rs4930312 chr11:65499719 G/A cg10518572 chr11:65560635 OVOL1 -0.25 -5.75 -0.3 1.97e-8 Acne (severe); LUSC cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg01028140 chr2:1542097 TPO -0.37 -6.08 -0.32 3.19e-9 IgG glycosylation; LUSC cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg26384229 chr12:38710491 ALG10B -0.91 -17.2 -0.69 6.01e-48 Heart rate; LUSC cis rs9487051 0.735 rs1146246 chr6:109519741 C/T cg01475377 chr6:109611718 NA -0.36 -6.11 -0.32 2.7e-9 Reticulocyte fraction of red cells; LUSC cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg06064525 chr11:970664 AP2A2 -0.48 -10.44 -0.5 2.9e-22 Alzheimer's disease (late onset); LUSC cis rs9815354 0.680 rs115754309 chr3:42017246 A/G cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC trans rs9329221 0.537 rs13254175 chr8:9978772 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.08 0.36 8.62e-12 Neuroticism; LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg05665937 chr4:1216051 CTBP1 0.38 5.98 0.31 5.89e-9 Obesity-related traits; LUSC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg09455208 chr3:40491958 NA -0.52 -9.7 -0.47 9.02e-20 Renal cell carcinoma; LUSC cis rs2797160 0.651 rs1268067 chr6:126036621 T/C cg05901451 chr6:126070800 HEY2 0.78 12.65 0.57 2.99e-30 Endometrial cancer; LUSC cis rs10504073 0.647 rs10808744 chr8:49988984 A/G cg00325661 chr8:49890786 NA 0.62 9.98 0.48 1.1e-20 Blood metabolite ratios; LUSC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11644478 chr21:40555479 PSMG1 -0.8 -13.99 -0.61 2.63e-35 Cognitive function; LUSC trans rs11764590 0.715 rs11760737 chr7:2104055 T/C cg10840412 chr1:235813424 GNG4 0.51 6.12 0.32 2.63e-9 Neuroticism; LUSC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg25019033 chr10:957182 NA -0.52 -5.94 -0.31 7.24e-9 Eosinophil percentage of granulocytes; LUSC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 -0.6 -8.7 -0.43 1.59e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg08048268 chr3:133502702 NA 0.47 8.96 0.44 2.35e-17 Iron status biomarkers; LUSC cis rs950027 0.620 rs1346267 chr15:45690989 A/G cg26924012 chr15:45694286 SPATA5L1 0.77 11.96 0.55 1.09e-27 Response to fenofibrate (adiponectin levels); LUSC cis rs868036 0.645 rs4492996 chr15:68113240 A/G cg24579218 chr15:68104479 NA -0.38 -6.74 -0.35 7.08e-11 Restless legs syndrome; LUSC cis rs9420 0.961 rs11601320 chr11:57642617 T/C cg23127183 chr11:57508653 C11orf31 -0.54 -7.84 -0.39 6e-14 Schizophrenia; LUSC cis rs977987 0.843 rs10431974 chr16:75435461 A/G cg03315344 chr16:75512273 CHST6 0.48 8.91 0.44 3.31e-17 Dupuytren's disease; LUSC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg09699651 chr6:150184138 LRP11 0.37 5.78 0.3 1.7e-8 Lung cancer; LUSC trans rs941408 0.515 rs1640265 chr19:2784405 C/T cg19676328 chr12:49525230 TUBA1B -0.54 -7.74 -0.39 1.19e-13 Total cholesterol levels; LUSC cis rs2797160 0.547 rs9401836 chr6:125956736 T/C cg05901451 chr6:126070800 HEY2 -0.42 -5.91 -0.31 8.39e-9 Endometrial cancer; LUSC cis rs7107174 1.000 rs7127187 chr11:77995188 G/A cg02023728 chr11:77925099 USP35 0.48 7.08 0.36 8.8e-12 Testicular germ cell tumor; LUSC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg18252515 chr7:66147081 NA -1.23 -14.17 -0.61 5.08e-36 Gout; LUSC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg12963246 chr6:28129442 ZNF389 0.5 6.45 0.33 4.02e-10 Parkinson's disease; LUSC cis rs2014572 0.870 rs10426580 chr19:57756221 G/A cg24459738 chr19:57751996 ZNF805 -0.52 -7.69 -0.39 1.66e-13 Hyperactive-impulsive symptoms; LUSC trans rs6601327 0.670 rs7004937 chr8:9420961 T/A cg15556689 chr8:8085844 FLJ10661 0.45 6.39 0.33 5.51e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.44 6.98 0.36 1.6e-11 Bipolar disorder; LUSC trans rs12439619 0.846 rs7496227 chr15:82567582 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.5 -6.66 -0.34 1.1e-10 Intelligence (multi-trait analysis); LUSC trans rs941408 1.000 rs1076447 chr19:2792128 C/G cg19676328 chr12:49525230 TUBA1B -0.5 -7.92 -0.4 3.59e-14 Total cholesterol levels; LUSC cis rs1153858 1.000 rs2453541 chr15:45645378 G/A cg14582100 chr15:45693742 SPATA5L1 0.57 10.11 0.48 3.85e-21 Homoarginine levels; LUSC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg00944433 chr1:107599041 PRMT6 -0.35 -6.27 -0.32 1.1e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9393777 1.000 rs9393777 chr6:26942027 T/C cg12826209 chr6:26865740 GUSBL1 0.77 7.67 0.39 1.92e-13 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg06784218 chr1:46089804 CCDC17 0.48 9.43 0.46 7e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.89 0.35 2.81e-11 Tonsillectomy; LUSC cis rs11690935 0.851 rs10201430 chr2:172813241 T/C cg13550731 chr2:172543902 DYNC1I2 -0.74 -11.69 -0.54 1.07e-26 Schizophrenia; LUSC cis rs7824557 0.564 rs2572400 chr8:11234367 T/G cg27411982 chr8:10470053 RP1L1 -0.37 -5.91 -0.31 8.24e-9 Retinal vascular caliber; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17713864 chr17:48784765 ANKRD40 -0.46 -6.18 -0.32 1.87e-9 Hepatitis; LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg00814883 chr7:100076585 TSC22D4 -0.75 -10.33 -0.49 7.12e-22 Platelet count; LUSC cis rs8077889 0.703 rs231534 chr17:41945564 C/T cg26893861 chr17:41843967 DUSP3 -0.81 -10.59 -0.5 8.59e-23 Triglycerides; LUSC cis rs709400 0.663 rs7152202 chr14:103886757 A/G cg12935359 chr14:103987150 CKB -0.52 -8.07 -0.4 1.24e-14 Body mass index; LUSC cis rs9467773 0.620 rs6925087 chr6:26592853 T/A cg09904177 chr6:26538194 HMGN4 0.68 12.18 0.55 1.72e-28 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618501 1.000 rs11130221 chr3:49819102 C/G cg13072238 chr3:49761600 GMPPB 0.39 6.42 0.33 4.61e-10 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.659 rs11495824 chr17:56918882 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.67 0.6 4.46e-34 Cognitive test performance; LUSC cis rs10740039 0.768 rs10994432 chr10:62383589 A/T cg18175470 chr10:62150864 ANK3 -0.45 -6.65 -0.34 1.22e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6582630 0.547 rs1589388 chr12:38416025 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.78e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.49 6.88 0.35 2.95e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs354225 0.544 rs12713265 chr2:54805409 C/T cg01766943 chr2:54829624 SPTBN1 0.46 7.43 0.38 8.96e-13 Schizophrenia; LUSC cis rs4423214 0.650 rs2186777 chr11:71219803 C/A cg05163923 chr11:71159392 DHCR7 0.61 8.05 0.4 1.46e-14 Vitamin D levels; LUSC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg02574844 chr11:5959923 NA -0.45 -6.36 -0.33 6.66e-10 DNA methylation (variation); LUSC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg17385448 chr1:15911702 AGMAT 0.35 5.97 0.31 6.18e-9 Systolic blood pressure; LUSC cis rs2835872 0.758 rs1709820 chr21:39035971 A/C cg20424643 chr21:39039972 KCNJ6 -0.44 -7.35 -0.37 1.57e-12 Electroencephalographic traits in alcoholism; LUSC cis rs2729354 0.953 rs1846567 chr11:57357593 T/C cg24343310 chr11:57249947 NA 0.36 6.53 0.34 2.48e-10 Blood protein levels; LUSC cis rs4474465 1.000 rs10899506 chr11:78168705 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.66 -0.3 3.32e-8 Alzheimer's disease (survival time); LUSC cis rs147144681 1 rs147144681 chr15:78900908 C/T cg18825076 chr15:78729989 IREB2 -0.5 -7.85 -0.39 5.8e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6831352 0.819 rs1230155 chr4:99989259 C/T cg12011299 chr4:100065546 ADH4 0.64 10.11 0.48 3.85e-21 Alcohol dependence; LUSC cis rs8068544 0.818 rs7209012 chr17:40161323 C/T cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -1.24 -11.41 -0.53 1.14e-25 Reticulocyte fraction of red cells;Reticulocyte count; LUSC cis rs2559856 1.000 rs10778139 chr12:102083202 C/T cg12924262 chr12:102091054 CHPT1 -0.42 -5.86 -0.31 1.12e-8 Blood protein levels; LUSC cis rs62400317 0.859 rs55779653 chr6:45265960 C/T cg18551225 chr6:44695536 NA -0.42 -7.08 -0.36 8.7e-12 Total body bone mineral density; LUSC cis rs12369179 1.000 rs12369179 chr12:122963550 C/T cg18578876 chr12:123200353 GPR109B -0.87 -7.06 -0.36 9.48e-12 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; LUSC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg03806693 chr22:41940476 POLR3H -0.96 -13.04 -0.58 1.08e-31 Vitiligo; LUSC cis rs238295 0.805 rs6053499 chr20:5542546 C/T cg15842884 chr20:5591925 RP5-1022P6.2 -0.41 -5.77 -0.3 1.84e-8 Occipital cortical area (total cortical area interaction); LUSC cis rs4690686 0.500 rs7667671 chr4:177275599 T/C cg17059388 chr4:177262070 NA 0.47 8.66 0.43 2.06e-16 Essential tremor; LUSC cis rs4474465 0.688 rs10793336 chr11:78281867 A/G cg27205649 chr11:78285834 NARS2 0.56 6.74 0.35 7.04e-11 Alzheimer's disease (survival time); LUSC cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg13010199 chr12:38710504 ALG10B 0.67 10.19 0.49 2.03e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7215564 0.908 rs4889884 chr17:78664465 A/G cg23238734 chr17:78661607 RPTOR 0.48 6.12 0.32 2.63e-9 Myopia (pathological); LUSC cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg14458575 chr2:238380390 NA 0.74 12.98 0.58 1.84e-31 Prostate cancer; LUSC cis rs7246657 0.551 rs11084873 chr19:37583910 A/G cg23950597 chr19:37808831 NA -0.55 -6.05 -0.31 3.86e-9 Coronary artery calcification; LUSC trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg01620082 chr3:125678407 NA -0.7 -7.25 -0.37 2.89e-12 Depression; LUSC cis rs7000551 0.751 rs1116085 chr8:22394920 A/G cg12081754 chr8:22256438 SLC39A14 0.43 6.4 0.33 5.15e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs12579753 0.956 rs34146892 chr12:82188581 T/G cg21231944 chr12:82153410 PPFIA2 -0.38 -5.88 -0.31 9.83e-9 Resting heart rate; LUSC trans rs8072100 0.666 rs6503804 chr17:45772447 G/A cg03886242 chr7:26192032 NFE2L3 -0.41 -6.25 -0.32 1.28e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs75920871 0.588 rs7119185 chr11:116886096 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.7 -0.34 8.86e-11 Subjective well-being; LUSC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.84 12.9 0.58 3.62e-31 Smoking behavior; LUSC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg10253484 chr15:75165896 SCAMP2 -0.49 -7.46 -0.38 7.72e-13 Breast cancer; LUSC cis rs926938 0.527 rs360583 chr1:115462743 C/T cg01522456 chr1:115632236 TSPAN2 -0.41 -6.44 -0.33 4.23e-10 Autism; LUSC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg22437258 chr11:111473054 SIK2 0.48 6.51 0.34 2.69e-10 Primary sclerosing cholangitis; LUSC cis rs11630290 0.640 rs1811744 chr15:64167428 T/C cg12036633 chr15:63758958 NA 0.5 6.1 0.32 2.89e-9 Iris characteristics; LUSC cis rs8077577 0.945 rs997315 chr17:18085286 A/G cg16794390 chr17:18148240 FLII 0.44 6.19 0.32 1.72e-9 Obesity-related traits; LUSC cis rs11997175 0.646 rs6468197 chr8:33734894 G/T ch.8.33884649F chr8:33765107 NA 0.53 8.04 0.4 1.59e-14 Body mass index; LUSC cis rs11112613 0.713 rs17041546 chr12:105950801 G/T cg03607813 chr12:105948248 NA -0.81 -12.68 -0.57 2.35e-30 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs9303280 0.685 rs9916765 chr17:38005595 T/C cg10909506 chr17:38081995 ORMDL3 0.32 5.68 0.3 2.88e-8 Self-reported allergy; LUSC cis rs1865721 1.000 rs11659761 chr18:73186974 A/G cg26385618 chr18:73139727 C18orf62 -0.43 -6.94 -0.35 2.07e-11 Intelligence; LUSC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg16447950 chr5:562315 NA -0.43 -6.4 -0.33 5.4e-10 Obesity-related traits; LUSC cis rs11122272 0.735 rs2486734 chr1:231531392 A/G cg06096015 chr1:231504339 EGLN1 0.58 10.39 0.49 4.2e-22 Hemoglobin concentration; LUSC cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg15448220 chr1:150897856 SETDB1 0.4 5.85 0.3 1.18e-8 Melanoma; LUSC cis rs11168618 0.743 rs12815151 chr12:48874836 A/C cg24011408 chr12:48396354 COL2A1 0.38 6.06 0.31 3.62e-9 Adiponectin levels; LUSC cis rs6582630 0.537 rs66855609 chr12:38299029 T/C cg13010199 chr12:38710504 ALG10B 0.64 10.0 0.48 9.35e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg25036284 chr2:26402008 FAM59B -0.68 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC cis rs977987 0.806 rs35787595 chr16:75466847 G/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.4e-11 Dupuytren's disease; LUSC cis rs1728785 0.688 rs698729 chr16:68624205 G/C cg02972257 chr16:68554789 NA -0.51 -6.26 -0.32 1.21e-9 Ulcerative colitis; LUSC cis rs9929218 0.911 rs4783686 chr16:68834156 C/G cg02972257 chr16:68554789 NA 0.42 5.74 0.3 2.09e-8 Colorectal cancer; LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg07507251 chr3:52567010 NT5DC2 0.36 6.91 0.35 2.39e-11 Bipolar disorder; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg01855118 chr6:157007725 NA 0.45 6.66 0.34 1.15e-10 Triglycerides; LUSC cis rs2652834 0.528 rs12908992 chr15:63428427 A/G cg05507819 chr15:63340323 TPM1 -0.82 -6.28 -0.33 1.03e-9 HDL cholesterol; LUSC cis rs922692 0.744 rs4886592 chr15:79082547 T/C cg00540400 chr15:79124168 NA -0.41 -7.08 -0.36 8.5e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg04414720 chr1:150670196 GOLPH3L 0.52 8.31 0.41 2.42e-15 Melanoma; LUSC cis rs4737010 0.501 rs12548116 chr8:41645074 A/G cg17182837 chr8:41585554 ANK1 -0.38 -6.69 -0.34 9.23e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs7086627 0.515 rs6585994 chr10:82191643 A/G cg01528321 chr10:82214614 TSPAN14 0.64 9.49 0.46 4.45e-19 Post bronchodilator FEV1; LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg07677032 chr17:61819896 STRADA 0.54 9.15 0.45 5.76e-18 Prudent dietary pattern; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg19747945 chr6:42946146 PEX6 -0.34 -5.67 -0.3 3.11e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg10802521 chr3:52805072 NEK4 -0.54 -8.8 -0.43 7.6e-17 Bipolar disorder; LUSC cis rs7267979 0.933 rs2261109 chr20:25259200 T/C cg08601574 chr20:25228251 PYGB 0.44 6.76 0.35 6.18e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC cis rs981844 1.000 rs62325092 chr4:154668674 T/C cg14289246 chr4:154710475 SFRP2 0.48 6.03 0.31 4.34e-9 Response to statins (LDL cholesterol change); LUSC trans rs3198697 1.000 rs3198697 chr16:15129940 C/T cg04492929 chr16:2155436 PKD1 -0.31 -6.03 -0.31 4.36e-9 Triglycerides; LUSC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.54 8.87 0.44 4.51e-17 Prudent dietary pattern; LUSC cis rs11676348 0.818 rs7426289 chr2:218966315 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.76 -0.3 1.88e-8 Ulcerative colitis; LUSC cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg10820045 chr2:198174542 NA -0.33 -6.02 -0.31 4.49e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg20276088 chr3:133502917 NA 0.37 5.69 0.3 2.78e-8 Iron status biomarkers; LUSC cis rs7937682 0.883 rs11213941 chr11:111434094 T/C cg19812747 chr11:111475976 SIK2 0.55 7.85 0.39 5.81e-14 Primary sclerosing cholangitis; LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg08677398 chr8:58056175 NA 0.53 7.08 0.36 8.75e-12 Developmental language disorder (linguistic errors); LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg08470875 chr2:26401718 FAM59B 0.75 9.99 0.48 1e-20 Gut microbiome composition (summer); LUSC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg26314531 chr2:26401878 FAM59B -0.68 -9.11 -0.45 7.87e-18 Gut microbiome composition (summer); LUSC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg09034736 chr1:150693464 HORMAD1 -0.48 -7.09 -0.36 8.03e-12 Tonsillectomy; LUSC cis rs806215 1.000 rs806214 chr7:127237003 C/T cg25922125 chr7:127225783 GCC1 -0.59 -7.15 -0.36 5.49e-12 Type 2 diabetes; LUSC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg00745463 chr17:30367425 LRRC37B -0.71 -8.74 -0.43 1.14e-16 Hip circumference adjusted for BMI; LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg19346786 chr7:2764209 NA 0.39 6.74 0.35 6.9e-11 Height; LUSC cis rs7568458 0.840 rs2886722 chr2:85742297 C/T cg23752985 chr2:85803571 VAMP8 -0.31 -6.57 -0.34 1.91e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7523273 0.526 rs1204706 chr1:208021060 G/T cg22525895 chr1:207977042 MIR29B2 -0.39 -6.28 -0.32 1.06e-9 Schizophrenia; LUSC trans rs7939886 0.920 rs7112964 chr11:55866408 T/C cg15704280 chr7:45808275 SEPT13 0.79 6.65 0.34 1.23e-10 Myopia (pathological); LUSC cis rs1577917 0.771 rs9362237 chr6:86409064 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 10.36 0.49 5.24e-22 Response to antipsychotic treatment; LUSC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg15448220 chr1:150897856 SETDB1 0.44 6.49 0.33 3.08e-10 Melanoma; LUSC cis rs6582630 0.598 rs12823134 chr12:38514347 T/A cg13010199 chr12:38710504 ALG10B -0.43 -6.52 -0.34 2.67e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6495367 1.000 rs755362 chr15:79376601 C/T cg17916960 chr15:79447300 NA -0.35 -6.59 -0.34 1.67e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9660992 0.674 rs56198325 chr1:205265450 G/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.54 -0.46 3e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg21017887 chr14:105400489 NA 0.66 12.75 0.57 1.34e-30 Rheumatoid arthritis; LUSC cis rs6121246 0.909 rs4518038 chr20:30419051 A/G cg13852791 chr20:30311386 BCL2L1 0.91 11.5 0.53 5.28e-26 Mean corpuscular hemoglobin; LUSC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg04025307 chr7:1156635 C7orf50 -0.5 -7.98 -0.4 2.37e-14 Longevity;Endometriosis; LUSC cis rs950776 0.518 rs2292117 chr15:78834689 C/T cg22563815 chr15:78856949 CHRNA5 0.26 6.23 0.32 1.37e-9 Sudden cardiac arrest; LUSC cis rs5769707 0.837 rs5769709 chr22:50021757 C/T cg08680598 chr22:49984980 NA -0.33 -6.23 -0.32 1.4e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg13010199 chr12:38710504 ALG10B -0.62 -10.36 -0.49 5.5e-22 Heart rate; LUSC cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.36 5.68 0.3 2.94e-8 Ulcerative colitis; LUSC cis rs6580649 0.941 rs726354 chr12:48500334 G/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.1 -0.32 2.9e-9 Lung cancer; LUSC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg18131467 chr2:239335373 ASB1 1.0 24.24 0.8 1.32e-75 Multiple system atrophy; LUSC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12667521 chr19:29218732 NA 0.62 8.99 0.44 1.87e-17 Methadone dose in opioid dependence; LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg18225595 chr11:63971243 STIP1 -0.47 -7.62 -0.38 2.71e-13 Platelet count; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg05165339 chr4:1420672 NA -0.3 -6.94 -0.35 2.09e-11 Longevity; LUSC cis rs950169 0.724 rs11632668 chr15:84948687 T/C cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs2806561 0.765 rs641808 chr1:23514123 T/G cg12483005 chr1:23474871 LUZP1 0.42 6.62 0.34 1.4e-10 Height; LUSC cis rs9300255 0.602 rs1790098 chr12:123655481 A/C cg00376283 chr12:123451042 ABCB9 0.65 8.22 0.41 4.63e-15 Neutrophil percentage of white cells; LUSC cis rs9300255 0.602 rs1727306 chr12:123665695 A/G cg00376283 chr12:123451042 ABCB9 0.67 8.36 0.42 1.68e-15 Neutrophil percentage of white cells; LUSC cis rs1728785 1.000 rs4783653 chr16:68562815 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.89 -0.31 9.61e-9 Ulcerative colitis; LUSC cis rs13217239 0.646 rs4269366 chr6:27016413 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 0.31 5.84 0.3 1.24e-8 Schizophrenia; LUSC cis rs6964587 1.000 rs10234290 chr7:91716951 T/C cg22709100 chr7:91322751 NA 0.4 5.85 0.3 1.17e-8 Breast cancer; LUSC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.59 -0.34 1.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg13047869 chr3:10149882 C3orf24 0.61 8.67 0.43 1.93e-16 Alzheimer's disease; LUSC cis rs9430161 0.645 rs12081186 chr1:11034195 T/C cg02454025 chr1:11042201 C1orf127 1.03 18.59 0.71 1.77e-53 Ewing sarcoma; LUSC cis rs7086627 0.515 rs6585994 chr10:82191643 A/G cg00277334 chr10:82204260 NA -0.63 -10.59 -0.5 8.65e-23 Post bronchodilator FEV1; LUSC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg25456477 chr12:86230367 RASSF9 -0.32 -5.65 -0.3 3.46e-8 Major depressive disorder; LUSC cis rs62400317 0.859 rs12199256 chr6:45303493 T/G cg18551225 chr6:44695536 NA -0.45 -7.44 -0.38 8.38e-13 Total body bone mineral density; LUSC cis rs9902453 0.904 rs4528633 chr17:28356136 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.53 -0.5 1.46e-22 Coffee consumption (cups per day); LUSC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.71 -0.34 8.54e-11 Lung cancer; LUSC cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg24531977 chr5:56204891 C5orf35 -0.57 -8.2 -0.41 5.16e-15 Coronary artery disease; LUSC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg17211192 chr8:82754475 SNX16 0.81 11.11 0.52 1.32e-24 Diastolic blood pressure; LUSC cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg25208724 chr1:156163844 SLC25A44 0.9 14.83 0.63 1.4e-38 Testicular germ cell tumor; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17105151 chr1:32666292 CCDC28B 0.42 6.19 0.32 1.77e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1395 0.778 rs1978881 chr2:27400850 C/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.49 7.26 0.37 2.77e-12 Blood metabolite levels; LUSC cis rs2249625 0.545 rs2496488 chr6:72875985 A/T cg18830697 chr6:72922368 RIMS1 -0.36 -7.26 -0.37 2.69e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs68170813 0.559 rs78064065 chr7:106967440 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.75 -0.3 2.05e-8 Coronary artery disease; LUSC cis rs8099014 0.861 rs8097365 chr18:56131080 G/A cg12907477 chr18:56117327 MIR122 0.46 7.02 0.36 1.28e-11 Platelet count; LUSC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg16145915 chr7:1198662 ZFAND2A -0.43 -6.28 -0.33 1.03e-9 Bronchopulmonary dysplasia; LUSC cis rs7107174 1.000 rs11237471 chr11:78082604 C/T cg02023728 chr11:77925099 USP35 0.44 6.52 0.34 2.64e-10 Testicular germ cell tumor; LUSC cis rs7561273 0.586 rs4149372 chr2:24305512 T/G cg20701182 chr2:24300061 SF3B14 0.51 6.58 0.34 1.78e-10 Quantitative traits; LUSC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg05340658 chr4:99064831 C4orf37 0.63 10.64 0.5 5.75e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9814567 1.000 rs6806417 chr3:134211446 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 13.84 0.6 9.47e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs8073060 0.533 rs178736 chr17:33928158 G/T cg19694781 chr19:47549865 TMEM160 -1.15 -18.32 -0.71 2.27e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs8078723 0.546 rs8067817 chr17:38163936 C/T cg17467752 chr17:38218738 THRA 0.5 7.39 0.37 1.17e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg21238619 chr17:78079768 GAA 0.46 8.68 0.43 1.81e-16 Yeast infection; LUSC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.54 -6.99 -0.36 1.52e-11 Schizophrenia; LUSC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg03433033 chr1:76189801 ACADM 0.72 9.62 0.47 1.67e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg21385522 chr1:16154831 NA 0.7 10.51 0.5 1.6400000000000001e-22 Dilated cardiomyopathy; LUSC cis rs17270561 0.525 rs12201678 chr6:25978993 C/T cg17042849 chr6:26104293 HIST1H4C -0.62 -7.12 -0.36 6.86e-12 Iron status biomarkers; LUSC cis rs2228479 0.541 rs9806913 chr16:89953773 A/G cg04013166 chr16:89971882 TCF25 0.62 7.24 0.37 3.1e-12 Skin colour saturation; LUSC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg10968187 chr4:17616003 MED28 -0.38 -5.69 -0.3 2.71e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6121246 0.567 rs6120890 chr20:30207659 T/G cg18721089 chr20:30220636 NA -0.41 -6.49 -0.33 3.1e-10 Mean corpuscular hemoglobin; LUSC cis rs1865760 0.622 rs10946807 chr6:26079638 T/C cg17691542 chr6:26056736 HIST1H1C 0.67 9.98 0.48 1.03e-20 Height; LUSC cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg26384229 chr12:38710491 ALG10B 0.84 13.62 0.6 6.77e-34 Bladder cancer; LUSC cis rs4704187 0.687 rs9293642 chr5:74365026 C/T cg03227963 chr5:74354835 NA 0.32 6.99 0.36 1.49e-11 Response to amphetamines; LUSC cis rs7760535 0.763 rs10457240 chr6:111848874 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.4 -7.63 -0.39 2.49e-13 Metabolic traits; LUSC cis rs2019216 0.542 rs7405615 chr17:21935430 C/G cg22648282 chr17:21454238 C17orf51 -0.53 -7.71 -0.39 1.46e-13 Pelvic organ prolapse; LUSC cis rs9815354 1.000 rs1564716 chr3:41862613 A/G cg03022575 chr3:42003672 ULK4 0.59 6.57 0.34 1.93e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14442939 chr10:27389572 ANKRD26 0.84 9.84 0.47 3.2e-20 Breast cancer; LUSC cis rs76878669 0.561 rs4930363 chr11:66169676 C/T cg24851651 chr11:66362959 CCS -0.4 -6.52 -0.34 2.63e-10 Educational attainment (years of education); LUSC cis rs950169 0.614 rs765524 chr15:84681782 G/T cg12863693 chr15:85201151 NMB 0.34 6.15 0.32 2.27e-9 Schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg17843125 chr1:100598159 SASS6;CCDC76 -0.41 -5.96 -0.31 6.58e-9 Hepatitis; LUSC trans rs953492 0.672 rs10926964 chr1:243359347 G/A cg04438194 chr4:119512985 NA -0.41 -6.05 -0.31 3.86e-9 Diastolic blood pressure; LUSC cis rs7147624 0.938 rs10467734 chr14:65913947 C/T cg03016385 chr14:66212404 NA -0.85 -9.62 -0.47 1.74e-19 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs4596713 0.568 rs7034179 chr9:71746838 C/T cg25283916 chr1:242222868 NA -0.3 -6.17 -0.32 2e-9 Headache; LUSC cis rs17253792 0.822 rs8018142 chr14:56173288 C/T cg01858014 chr14:56050164 KTN1 -0.74 -6.32 -0.33 8.44e-10 Putamen volume; LUSC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg18404041 chr3:52824283 ITIH1 -0.43 -7.39 -0.37 1.21e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.68 0.39 1.75e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12474201 0.572 rs7596521 chr2:46918665 A/G cg09399716 chr2:46890238 NA -0.42 -8.95 -0.44 2.52e-17 Height; LUSC trans rs17685 0.712 rs1859792 chr7:75789264 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 18.81 0.72 2.36e-54 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg13628971 chr7:2884303 GNA12 0.46 6.66 0.34 1.14e-10 Height; LUSC cis rs2230307 0.536 rs490669 chr1:100484430 C/T cg24955406 chr1:100503596 HIAT1 0.57 6.14 0.32 2.35e-9 Carotid intima media thickness; LUSC cis rs9303401 0.659 rs11079358 chr17:56920949 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.35 0.59 7.08e-33 Cognitive test performance; LUSC cis rs7481584 0.624 rs516443 chr11:3047294 A/G cg05729581 chr11:3078854 CARS 0.4 5.92 0.31 7.83e-9 Calcium levels; LUSC cis rs559928 0.606 rs76653616 chr11:63936139 T/G cg05555928 chr11:63887634 MACROD1 -0.49 -6.05 -0.31 3.95e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06320606 chr5:60139941 ELOVL7 -0.51 -6.66 -0.34 1.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.03 0.58 1.11e-31 Chronic sinus infection; LUSC cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg15744005 chr10:104629667 AS3MT -0.33 -6.79 -0.35 5.08e-11 Arsenic metabolism; LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg25296646 chr22:38349726 POLR2F;C22orf23 -0.39 -6.25 -0.32 1.29e-9 Amyotrophic lateral sclerosis (age of onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08134618 chr7:8008133 GLCCI1 -0.47 -7.06 -0.36 9.81e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3820928 0.874 rs4144328 chr2:227790187 A/C cg11843606 chr2:227700838 RHBDD1 -0.52 -7.62 -0.39 2.57e-13 Pulmonary function; LUSC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg04287289 chr16:89883240 FANCA 0.47 6.85 0.35 3.5e-11 Hemoglobin concentration; LUSC cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg06784218 chr1:46089804 CCDC17 0.47 9.26 0.45 2.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg19717773 chr7:2847554 GNA12 -0.34 -5.68 -0.3 2.95e-8 Height; LUSC cis rs72960926 0.744 rs115559526 chr6:75027796 T/G cg03266952 chr6:74778945 NA -0.87 -6.36 -0.33 6.5e-10 Metabolite levels (MHPG); LUSC cis rs4919694 1.000 rs12253284 chr10:104665145 G/C cg23093090 chr10:104574429 C10orf26 -0.46 -5.74 -0.3 2.12e-8 Arsenic metabolism; LUSC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg24768116 chr2:27665128 KRTCAP3 -0.31 -6.31 -0.33 8.62e-10 Total body bone mineral density; LUSC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg20243544 chr17:37824526 PNMT 0.5 7.21 0.37 3.83e-12 Asthma; LUSC cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.68 0.7 7.58e-50 Chronic sinus infection; LUSC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg19912559 chr1:40204330 PPIE 0.53 8.18 0.41 6.17e-15 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12044295 chr8:56686133 TMEM68;TGS1 -0.41 -6.41 -0.33 4.84e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs6964587 0.758 rs35963176 chr7:91617115 C/T cg17063962 chr7:91808500 NA 0.54 7.47 0.38 7.14e-13 Breast cancer; LUSC cis rs12701220 0.817 rs59471534 chr7:1085224 G/A cg20821713 chr7:1055600 C7orf50 -0.48 -6.59 -0.34 1.74e-10 Bronchopulmonary dysplasia; LUSC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg06481639 chr22:41940642 POLR3H -0.48 -5.99 -0.31 5.38e-9 Vitiligo; LUSC cis rs4812048 0.649 rs6100319 chr20:57626568 A/C cg14073986 chr20:57617431 SLMO2 0.88 9.5 0.46 4.16e-19 Mean platelet volume; LUSC cis rs6964587 0.585 rs10266481 chr7:91554338 T/C cg17063962 chr7:91808500 NA -0.56 -9.23 -0.45 3.27e-18 Breast cancer; LUSC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg27211696 chr2:191398769 TMEM194B -0.59 -11.34 -0.53 2.02e-25 Pulse pressure; LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 5e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11168618 0.904 rs10875829 chr12:48927197 A/C cg24011408 chr12:48396354 COL2A1 0.39 6.34 0.33 7.56e-10 Adiponectin levels; LUSC trans rs4332037 0.950 rs11771828 chr7:1941003 T/C cg10840412 chr1:235813424 GNG4 0.68 9.13 0.45 6.54e-18 Bipolar disorder; LUSC cis rs1670533 1.000 rs2290411 chr4:1051077 T/C cg19318889 chr4:1322082 MAEA 0.43 5.66 0.3 3.22e-8 Recombination rate (females); LUSC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg17971929 chr21:40555470 PSMG1 0.65 10.44 0.5 2.87e-22 Cognitive function; LUSC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC trans rs60843830 0.964 rs62114538 chr2:256116 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.79 0.47 4.65e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg10755058 chr3:40428713 ENTPD3 0.36 5.83 0.3 1.29e-8 Renal cell carcinoma; LUSC cis rs6500602 0.702 rs17761816 chr16:4548832 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 6.74 0.35 6.82e-11 Schizophrenia; LUSC cis rs1003719 0.788 rs2835575 chr21:38455936 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.41 0.53 1.08e-25 Eye color traits; LUSC cis rs668210 0.793 rs590531 chr11:65773939 C/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.59 -7.62 -0.38 2.73e-13 Cerebrospinal fluid biomarker levels; LUSC cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.93 0.31 7.55e-9 Rheumatoid arthritis; LUSC cis rs6714710 0.603 rs11123974 chr2:98605982 A/G cg26665480 chr2:98280029 ACTR1B 0.56 8.08 0.4 1.18e-14 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs9865818 0.702 rs6790260 chr3:188117079 C/G cg23651889 chr3:188115336 LPP 0.39 5.92 0.31 8.07e-9 Allergic sensitization; LUSC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg21770322 chr7:97807741 LMTK2 0.4 7.05 0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.52 -0.38 5.06e-13 Height; LUSC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg20503657 chr10:835505 NA 0.78 9.77 0.47 5.42e-20 Eosinophil percentage of granulocytes; LUSC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg11941060 chr3:133502564 NA -0.53 -8.03 -0.4 1.67e-14 Iron status biomarkers; LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.875 rs2748490 chr6:146329681 G/T cg05347473 chr6:146136440 FBXO30 0.5 8.45 0.42 8.88e-16 Lobe attachment (rater-scored or self-reported); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00959118 chr1:169455055 SLC19A2 -0.4 -6.04 -0.31 4.1e-9 Hepatitis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg14173624 chr17:72199366 RPL38 0.43 6.43 0.33 4.42e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs62238980 0.614 rs80035296 chr22:32387536 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5.04e-9 Childhood ear infection; LUSC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.85 0.31 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs1865721 0.839 rs59718187 chr18:73144032 C/T cg26385618 chr18:73139727 C18orf62 -0.53 -9.69 -0.47 9.64e-20 Intelligence; LUSC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg16928487 chr17:17741425 SREBF1 0.38 7.29 0.37 2.3e-12 Total body bone mineral density; LUSC cis rs35146811 0.735 rs1061230 chr7:99807265 G/A cg22906224 chr7:99728672 NA -0.47 -6.58 -0.34 1.84e-10 Coronary artery disease; LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg25767906 chr1:53392781 SCP2 0.52 9.56 0.46 2.72e-19 Monocyte count; LUSC cis rs9399135 0.967 rs4895436 chr6:135295001 G/A cg24558204 chr6:135376177 HBS1L 0.58 9.0 0.44 1.69e-17 Red blood cell count; LUSC cis rs17621444 0.522 rs10886574 chr10:121792801 C/T cg02041677 chr10:121771263 NA -0.34 -6.32 -0.33 8.17e-10 IgG glycosylation; LUSC cis rs7614311 0.731 rs56126667 chr3:63866286 A/G cg22134162 chr3:63841271 THOC7 -0.49 -6.07 -0.32 3.43e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg01256987 chr12:42539512 GXYLT1 -0.46 -8.71 -0.43 1.47e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs853679 0.517 rs1904841 chr6:28108085 C/T cg06606381 chr12:133084897 FBRSL1 -0.46 -6.01 -0.31 4.85e-9 Depression; LUSC cis rs3845702 0.800 rs6744281 chr2:180844382 G/A cg01881094 chr2:180872142 CWC22 -1.04 -12.57 -0.57 6.35e-30 Schizophrenia; LUSC cis rs1577917 0.739 rs9344532 chr6:86234070 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 10.16 0.49 2.57e-21 Response to antipsychotic treatment; LUSC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg03676636 chr4:99064102 C4orf37 0.36 7.77 0.39 9.65e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs7613875 0.600 rs2624826 chr3:50155468 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -8.2 -0.41 5.37e-15 Body mass index; LUSC trans rs3960554 0.808 rs79864016 chr7:75655838 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 9.66 0.47 1.22e-19 Eotaxin levels; LUSC cis rs9467773 0.596 rs2451750 chr6:26646579 A/T cg09904177 chr6:26538194 HMGN4 0.66 11.81 0.54 3.86e-27 Intelligence (multi-trait analysis); LUSC trans rs1325195 0.920 rs2816209 chr1:179171494 A/G cg11624085 chr17:8464688 MYH10 0.44 6.91 0.35 2.49e-11 IgE grass sensitization; LUSC cis rs7937682 0.632 rs12785809 chr11:111776055 T/A cg09085632 chr11:111637200 PPP2R1B 0.93 12.58 0.57 5.56e-30 Primary sclerosing cholangitis; LUSC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg13607699 chr17:42295918 UBTF -0.73 -12.67 -0.57 2.61e-30 Red cell distribution width;Reticulocyte count; LUSC cis rs778371 0.723 rs283470 chr2:233656918 G/A cg08000102 chr2:233561755 GIGYF2 0.8 13.3 0.59 1.09e-32 Schizophrenia; LUSC cis rs2835872 0.965 rs17814920 chr21:39015897 C/T cg20424643 chr21:39039972 KCNJ6 0.41 6.17 0.32 1.97e-9 Electroencephalographic traits in alcoholism; LUSC cis rs68170813 0.559 rs3801959 chr7:106955666 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.33 0.67 1.77e-44 Platelet count; LUSC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC cis rs60015123 0.850 rs57438850 chr12:7100540 C/T cg26269324 chr12:6977084 TPI1 0.78 6.01 0.31 4.91e-9 Red cell distribution width; LUSC cis rs4595586 0.545 rs925828 chr12:39364222 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs9814567 1.000 rs7432268 chr3:134242051 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.71 -0.6 2.98e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs68092024 0.704 rs704575 chr3:99486075 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.36 -7.02 -0.36 1.28e-11 Cleft lip with or without cleft palate; LUSC cis rs599083 0.793 rs471966 chr11:68173861 C/T cg16797656 chr11:68205561 LRP5 -0.38 -6.31 -0.33 8.85e-10 Bone mineral density (spine); LUSC trans rs11039798 0.541 rs11040166 chr11:48965449 T/C cg03929089 chr4:120376271 NA 0.73 6.31 0.33 8.91e-10 Axial length; LUSC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg11645453 chr3:52864694 ITIH4 0.35 8.16 0.41 6.82e-15 Bipolar disorder; LUSC cis rs3106136 1.000 rs2664871 chr4:95146281 A/G cg11021082 chr4:95130006 SMARCAD1 0.34 6.11 0.32 2.76e-9 Capecitabine sensitivity; LUSC cis rs6599077 1.000 rs2068978 chr3:40095238 T/C cg13683864 chr3:40499215 RPL14 -0.6 -7.66 -0.39 2.06e-13 Sleep-related phenotypes; LUSC cis rs2200578 1.000 rs60025964 chr2:99880577 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.57 6.55 0.34 2.16e-10 IgG glycosylation; LUSC cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg26384229 chr12:38710491 ALG10B 0.87 14.25 0.61 2.49e-36 Bladder cancer; LUSC cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg11244672 chr19:19639970 YJEFN3 -0.59 -7.31 -0.37 2.01e-12 Bipolar disorder; LUSC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.58 -0.38 3.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs11122272 0.735 rs2808611 chr1:231548480 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.66 10.43 0.5 3.17e-22 Hemoglobin concentration; LUSC cis rs7582180 0.629 rs11686799 chr2:100956055 C/G cg14675211 chr2:100938903 LONRF2 0.37 5.73 0.3 2.29e-8 Intelligence (multi-trait analysis); LUSC cis rs3806843 0.676 rs2563304 chr5:140072057 C/T cg26395211 chr5:140044315 WDR55 0.45 6.99 0.36 1.5e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs7267979 0.934 rs4815423 chr20:25387521 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.68 -0.34 1.03e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9403521 0.947 rs7741424 chr6:143981662 G/A cg18240653 chr6:144019428 PHACTR2 -0.52 -6.16 -0.32 2.13e-9 Obesity-related traits; LUSC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs1451375 0.698 rs12669770 chr7:50656334 G/A cg18232548 chr7:50535776 DDC 0.51 7.55 0.38 4.29e-13 Malaria; LUSC cis rs3862260 0.967 rs3862261 chr1:120160822 G/A cg11530693 chr1:120165357 ZNF697 0.51 7.92 0.4 3.49e-14 Systemic lupus erythematosus; LUSC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.84 -0.3 1.21e-8 Tonsillectomy; LUSC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.06e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 11.03 0.52 2.45e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg21951975 chr1:209979733 IRF6 -0.48 -8.18 -0.41 5.98e-15 Orofacial clefts; LUSC cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.63e-17 Motion sickness; LUSC cis rs9640161 0.830 rs11972067 chr7:150071605 G/A cg17279839 chr7:150038598 RARRES2 0.35 5.76 0.3 1.92e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg12463550 chr7:65579703 CRCP -0.42 -6.2 -0.32 1.64e-9 Aortic root size; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs2073300 1.000 rs6137976 chr20:23463241 C/T cg12062639 chr20:23401060 NAPB 0.73 5.67 0.3 3.06e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11190604 1.000 rs17113137 chr10:102241998 G/C cg07080220 chr10:102295463 HIF1AN 0.63 8.36 0.42 1.71e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9788682 0.747 rs2568497 chr15:78721397 G/T cg18825076 chr15:78729989 IREB2 -0.43 -5.91 -0.31 8.37e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7193541 0.965 rs8050262 chr16:74661159 T/C cg01733217 chr16:74700730 RFWD3 0.86 14.94 0.63 5.22e-39 Multiple myeloma; LUSC trans rs7613875 0.641 rs6793528 chr3:50100188 C/A cg21659725 chr3:3221576 CRBN -0.52 -8.38 -0.42 1.5e-15 Body mass index; LUSC cis rs113835537 0.866 rs59320108 chr11:66365996 A/T cg24851651 chr11:66362959 CCS 0.52 6.43 0.33 4.44e-10 Airway imaging phenotypes; LUSC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -7.1 -0.36 7.45e-12 Alzheimer's disease (late onset); LUSC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg04267008 chr7:1944627 MAD1L1 -0.54 -8.3 -0.41 2.56e-15 Bipolar disorder and schizophrenia; LUSC cis rs478607 0.831 rs3825074 chr11:64415767 G/A cg19131476 chr11:64387923 NRXN2 0.34 6.06 0.31 3.76e-9 Urate levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07709635 chr12:3000034 TULP3 0.43 5.99 0.31 5.56e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.05 0.52 2.16e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg12698349 chr2:225449008 CUL3 0.66 8.48 0.42 7.25e-16 IgE levels in asthmatics (D.p. specific); LUSC cis rs709400 0.628 rs72708854 chr14:103864885 T/C cg12935359 chr14:103987150 CKB -0.53 -8.12 -0.41 9.04e-15 Body mass index; LUSC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg00129232 chr17:37814104 STARD3 -0.41 -5.96 -0.31 6.38e-9 Asthma; LUSC cis rs1775715 0.705 rs2778651 chr10:32106575 C/T cg18675610 chr10:32216311 ARHGAP12 0.31 6.58 0.34 1.8e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs950169 0.580 rs36126054 chr15:85177723 T/G cg11189052 chr15:85197271 WDR73 0.5 6.39 0.33 5.56e-10 Schizophrenia; LUSC cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg19628046 chr18:33552617 C18orf21 0.5 6.11 0.32 2.83e-9 Endometriosis;Drug-induced torsades de pointes; LUSC trans rs66573146 0.656 rs41410847 chr4:6957332 C/T cg07817883 chr1:32538562 TMEM39B 1.02 10.16 0.49 2.69e-21 Granulocyte percentage of myeloid white cells; LUSC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg12863693 chr15:85201151 NMB 0.34 6.79 0.35 5.13e-11 Schizophrenia; LUSC cis rs751728 0.687 rs943471 chr6:33738314 C/T cg25922239 chr6:33757077 LEMD2 0.45 6.72 0.34 8e-11 Crohn's disease; LUSC cis rs754466 0.606 rs55854323 chr10:79589904 C/T cg17075019 chr10:79541650 NA -0.76 -12.12 -0.55 2.93e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg06671706 chr8:8559999 CLDN23 0.5 6.83 0.35 3.98e-11 Obesity-related traits; LUSC cis rs317689 0.959 rs317688 chr12:69726850 T/C cg14784868 chr12:69753453 YEATS4 0.56 7.18 0.37 4.6e-12 Response to diuretic therapy; LUSC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg16743903 chr16:89593216 SPG7 -0.39 -6.13 -0.32 2.54e-9 Multiple myeloma (IgH translocation); LUSC cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg25036284 chr2:26402008 FAM59B 0.77 10.97 0.51 3.94e-24 Gut microbiome composition (summer); LUSC trans rs7726839 0.561 rs4957049 chr5:579080 C/A cg25482853 chr8:67687455 SGK3 1.04 15.58 0.65 1.6e-41 Obesity-related traits; LUSC cis rs8028313 0.609 rs28735117 chr15:67933892 C/T cg08079166 chr15:68083412 MAP2K5 0.35 6.07 0.32 3.42e-9 Obesity; LUSC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg06544989 chr22:39130855 UNC84B 0.37 6.45 0.33 3.82e-10 Menopause (age at onset); LUSC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg19678392 chr7:94953810 PON1 -0.36 -5.65 -0.3 3.47e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg02380750 chr20:61661411 NA 0.34 5.92 0.31 7.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg09877947 chr5:131593287 PDLIM4 0.41 6.77 0.35 5.68e-11 Blood metabolite levels; LUSC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1775715 0.870 rs1251400 chr10:32235145 A/G cg03015672 chr10:32216066 ARHGAP12 0.33 6.02 0.31 4.72e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7809950 0.678 rs2237665 chr7:106906998 T/C cg23024343 chr7:107201750 COG5 -0.66 -10.06 -0.48 5.78e-21 Coronary artery disease; LUSC cis rs4423214 0.610 rs12789253 chr11:71125765 G/A cg05163923 chr11:71159392 DHCR7 0.55 8.12 0.41 9.22e-15 Vitamin D levels; LUSC cis rs4619890 0.528 rs62289335 chr4:7877655 G/C cg24250820 chr4:7887609 AFAP1 0.36 6.15 0.32 2.17e-9 Glaucoma (primary open-angle); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg16790682 chr12:57984821 PIP4K2C 0.46 6.29 0.33 1e-9 Mosquito bite size; LUSC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg07701084 chr6:150067640 NUP43 0.54 8.13 0.41 8.7e-15 Lung cancer; LUSC cis rs2239547 0.522 rs2581815 chr3:52982159 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.41 6.3 0.33 9.42e-10 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24034412 chr19:49122294 RPL18;SPHK2 -0.49 -6.52 -0.34 2.67e-10 Bipolar disorder and schizophrenia; LUSC cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg08999081 chr20:33150536 PIGU -0.4 -7.58 -0.38 3.53e-13 Glomerular filtration rate (creatinine); LUSC cis rs3772130 0.962 rs9848027 chr3:121551227 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.19 0.49 1.99e-21 Cognitive performance; LUSC cis rs7903847 0.544 rs61861865 chr10:99144867 C/G cg20016023 chr10:99160130 RRP12 -0.33 -8.07 -0.4 1.26e-14 Granulocyte percentage of myeloid white cells; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00106499 chr7:44163141 POLD2 -0.41 -5.95 -0.31 6.95e-9 Electrocardiographic conduction measures; LUSC cis rs892961 0.932 rs7208336 chr17:75412932 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC trans rs804280 0.543 rs13261205 chr8:11791216 A/G cg27411982 chr8:10470053 RP1L1 0.4 6.1 0.32 2.91e-9 Myopia (pathological); LUSC cis rs3859192 0.539 rs2305481 chr17:38138624 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.7 12.26 0.56 8.46e-29 White blood cell count; LUSC cis rs9788682 0.747 rs2568490 chr15:78738370 T/C cg18825076 chr15:78729989 IREB2 -0.45 -6.1 -0.32 2.87e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -11.77 -0.54 5.25e-27 Coronary artery disease; LUSC cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg15083037 chr5:83017644 HAPLN1 -0.61 -7.93 -0.4 3.22e-14 Prostate cancer; LUSC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg15352829 chr14:105391018 PLD4 -0.4 -8.41 -0.42 1.18e-15 Rheumatoid arthritis; LUSC cis rs699 0.556 rs2478517 chr1:230867887 A/G cg07502417 chr1:230849801 AGT 0.27 6.46 0.33 3.72e-10 Coronary artery disease; LUSC trans rs3960554 0.867 rs11489553 chr7:75843062 G/A cg19862616 chr7:65841803 NCRNA00174 0.89 9.56 0.46 2.71e-19 Eotaxin levels; LUSC cis rs9420 0.961 rs499188 chr11:57434122 C/A cg02958346 chr11:57425731 CLP1 -0.41 -5.98 -0.31 5.73e-9 Schizophrenia; LUSC cis rs6121246 0.529 rs6088814 chr20:30218172 C/T cg13852791 chr20:30311386 BCL2L1 0.77 8.73 0.43 1.25e-16 Mean corpuscular hemoglobin; LUSC cis rs66716358 0.744 rs10838253 chr11:44317477 C/T cg16977035 chr11:44330474 ALX4 0.35 5.76 0.3 1.87e-8 Monobrow; LUSC trans rs3857536 0.741 rs9363556 chr6:66934399 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs782590 0.902 rs782600 chr2:55848040 T/C cg18811423 chr2:55921094 PNPT1 0.78 13.25 0.59 1.72e-32 Metabolic syndrome; LUSC cis rs11997175 0.646 rs10954936 chr8:33686165 C/T ch.8.33884649F chr8:33765107 NA 0.48 7.11 0.36 7.29e-12 Body mass index; LUSC cis rs11785400 1.000 rs6997670 chr8:143737915 G/A cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC cis rs2486288 0.656 rs12899058 chr15:45547324 G/A cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.76 -0.51 2.15e-23 Glomerular filtration rate; LUSC cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg05347473 chr6:146136440 FBXO30 0.41 6.84 0.35 3.78e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2361718 0.967 rs12942941 chr17:78103013 C/T cg06718696 chr17:78121285 EIF4A3 0.44 6.26 0.32 1.16e-9 Yeast infection; LUSC cis rs7119 0.634 rs2667782 chr15:77862296 A/C cg27398640 chr15:77910606 LINGO1 0.36 7.96 0.4 2.63e-14 Type 2 diabetes; LUSC cis rs57024841 0.562 rs2071006 chr9:139839904 G/T cg00693599 chr9:139836323 FBXW5 -0.57 -10.15 -0.49 2.75e-21 Beta-trace protein levels; LUSC trans rs2797160 1.000 rs1777222 chr6:126021030 C/T cg05039488 chr6:79577232 IRAK1BP1 0.45 6.87 0.35 3.12e-11 Endometrial cancer; LUSC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg25427524 chr10:38739819 LOC399744 -0.72 -13.53 -0.6 1.46e-33 Extrinsic epigenetic age acceleration; LUSC cis rs34734847 0.750 rs3829290 chr12:121126438 T/C cg27246729 chr12:121163418 ACADS 0.41 6.54 0.34 2.35e-10 Mean corpuscular volume; LUSC cis rs6546550 0.901 rs1979214 chr2:70137498 G/C cg02498382 chr2:70120550 SNRNP27 -0.29 -7.29 -0.37 2.2e-12 Prevalent atrial fibrillation; LUSC cis rs10986311 0.802 rs3780201 chr9:127104775 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.43 -6.92 -0.35 2.37e-11 Vitiligo; LUSC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg13047869 chr3:10149882 C3orf24 -0.43 -6.03 -0.31 4.23e-9 Alzheimer's disease; LUSC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg01802117 chr1:53393560 SCP2 -0.37 -6.06 -0.31 3.74e-9 Monocyte count; LUSC trans rs1814175 0.935 rs6485999 chr11:49658986 G/C cg03929089 chr4:120376271 NA -0.99 -17.82 -0.7 2.23e-50 Height; LUSC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg02503808 chr4:7069936 GRPEL1 -1.05 -12.07 -0.55 4.51e-28 Monocyte percentage of white cells; LUSC cis rs11098499 0.562 rs13101722 chr4:120555975 C/A cg24375607 chr4:120327624 NA -0.63 -10.05 -0.48 6.3e-21 Corneal astigmatism; LUSC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg17376030 chr22:41985996 PMM1 -0.48 -6.02 -0.31 4.57e-9 Vitiligo; LUSC cis rs9369695 0.883 rs9381581 chr6:47580695 G/A cg02130027 chr6:47444894 CD2AP 0.36 5.76 0.3 1.86e-8 Reticulocyte count; LUSC cis rs921665 0.680 rs4411731 chr2:3189324 C/A cg02624386 chr2:3182749 NA 0.59 6.59 0.34 1.68e-10 World class endurance athleticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02125727 chr4:47916636 NFXL1 0.44 6.13 0.32 2.45e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg10130564 chr11:117069849 TAGLN 0.39 6.66 0.34 1.16e-10 Blood protein levels; LUSC cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg09998033 chr7:158218633 PTPRN2 0.44 6.98 0.36 1.56e-11 Obesity-related traits; LUSC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg06637938 chr14:75390232 RPS6KL1 -0.5 -8.0 -0.4 2.02e-14 Height; LUSC cis rs11048434 0.736 rs34798934 chr12:9108444 C/T cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC trans rs11098499 0.743 rs10003567 chr4:120241674 C/T cg25214090 chr10:38739885 LOC399744 0.43 6.58 0.34 1.77e-10 Corneal astigmatism; LUSC trans rs7243066 0.529 rs1391471 chr18:11297066 A/G cg23062198 chr2:14774063 FAM84A -0.45 -6.14 -0.32 2.4e-9 Dental caries; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16313264 chr11:57103491 SSRP1 0.46 6.06 0.31 3.59e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs35771425 0.626 rs11119744 chr1:211644575 C/T cg10512769 chr1:211675356 NA -0.26 -5.75 -0.3 2.05e-8 Educational attainment (years of education); LUSC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg18681998 chr4:17616180 MED28 0.84 15.62 0.65 1.13e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7953508 0.506 rs2053196 chr12:93962959 T/C cg18151635 chr12:93972918 NA -0.62 -8.96 -0.44 2.35e-17 Pubertal anthropometrics; LUSC cis rs4474465 1.000 rs10899518 chr11:78180508 A/C cg27205649 chr11:78285834 NARS2 -0.48 -5.71 -0.3 2.51e-8 Alzheimer's disease (survival time); LUSC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg23422044 chr7:1970798 MAD1L1 -0.59 -6.66 -0.34 1.11e-10 Bipolar disorder; LUSC trans rs12439619 0.693 rs4778989 chr15:82569304 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.45 -6.13 -0.32 2.44e-9 Intelligence (multi-trait analysis); LUSC trans rs629535 0.814 rs488231 chr8:70064993 T/C cg21567404 chr3:27674614 NA 0.97 15.32 0.64 1.75e-40 Dupuytren's disease; LUSC cis rs2795502 0.882 rs2744095 chr10:43337949 A/T cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg19346786 chr7:2764209 NA -0.41 -7.22 -0.37 3.64e-12 Height; LUSC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg12963246 chr6:28129442 ZNF389 0.4 6.25 0.32 1.27e-9 Parkinson's disease; LUSC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg04756594 chr16:24857601 SLC5A11 0.46 6.45 0.33 4.02e-10 Intelligence (multi-trait analysis); LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 13.19 0.59 2.92e-32 Alzheimer's disease; LUSC cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.21 16.82 0.68 1.93e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs4811340 0.561 rs4811367 chr20:51183224 G/A cg15736553 chr3:11610338 VGLL4 -0.33 -5.97 -0.31 5.9e-9 Thyroid peroxidase antibody positivity; LUSC cis rs3768617 0.811 rs6674729 chr1:183059143 C/T ch.1.3577855R chr1:183094577 LAMC1 0.61 8.73 0.43 1.26e-16 Fuchs's corneal dystrophy; LUSC cis rs9473147 0.543 rs9473122 chr6:47474962 C/T cg12968598 chr6:47444699 CD2AP 0.53 7.97 0.4 2.49e-14 Platelet distribution width;Mean platelet volume; LUSC trans rs7647973 0.710 rs34890793 chr3:49619493 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -7.4 -0.38 1.15e-12 Menarche (age at onset); LUSC cis rs1670533 1.000 rs641987 chr4:1077542 C/T cg27284194 chr4:1044797 NA 0.58 8.7 0.43 1.57e-16 Recombination rate (females); LUSC cis rs611744 0.647 rs628206 chr8:109247873 A/G cg18478394 chr8:109455254 TTC35 0.41 6.32 0.33 8.55e-10 Dupuytren's disease; LUSC cis rs7582720 0.943 rs72934762 chr2:203756677 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.2 -0.37 3.93e-12 Menopause (age at onset); LUSC cis rs6430585 0.528 rs309120 chr2:136708787 G/C cg07169764 chr2:136633963 MCM6 1.01 15.33 0.64 1.5e-40 Corneal structure; LUSC cis rs11098499 0.954 rs10024844 chr4:120311528 A/G cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs10779751 0.770 rs11581010 chr1:11212458 A/G cg08854313 chr1:11322531 MTOR -0.82 -12.15 -0.55 2.19e-28 Body mass index; LUSC cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg18225595 chr11:63971243 STIP1 0.43 6.95 0.36 1.98e-11 Platelet count; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg07167872 chr1:205819463 PM20D1 0.53 8.88 0.44 4.04e-17 Menarche (age at onset); LUSC cis rs2274273 0.837 rs8011329 chr14:55677255 G/A cg04306507 chr14:55594613 LGALS3 0.56 13.1 0.58 6.45e-32 Protein biomarker; LUSC cis rs7605827 0.930 rs13007310 chr2:15710058 A/G cg19274914 chr2:15703543 NA -0.45 -8.93 -0.44 2.81e-17 Educational attainment (years of education); LUSC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg02569458 chr12:86230093 RASSF9 -0.58 -9.89 -0.48 2.15e-20 Major depressive disorder; LUSC cis rs4629710 0.592 rs10484763 chr6:131549060 T/C cg12606694 chr6:131520996 AKAP7 0.61 9.21 0.45 3.72e-18 Multiple myeloma (IgH translocation); LUSC cis rs4930103 1.000 rs4929983 chr11:2024579 C/T cg06197492 chr11:2016605 H19 0.37 6.0 0.31 5.27e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06164185 chr17:26662378 TNFAIP1;IFT20 -0.42 -6.12 -0.32 2.61e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9300255 0.537 rs2682429 chr12:123642955 C/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.17 -0.32 1.95e-9 Neutrophil percentage of white cells; LUSC cis rs10266483 1.000 rs1960321 chr7:63731284 T/C cg24201672 chr7:64023550 ZNF680 -0.43 -5.97 -0.31 6.02e-9 Response to statin therapy; LUSC cis rs6693567 0.565 rs698914 chr1:150298750 A/G cg15654264 chr1:150340011 RPRD2 0.45 7.33 0.37 1.8e-12 Migraine; LUSC cis rs1451375 1.000 rs1451374 chr7:50622653 G/A cg18232548 chr7:50535776 DDC 0.51 7.83 0.39 6.32e-14 Malaria; LUSC cis rs1018836 0.851 rs10808620 chr8:91622940 T/C cg16814680 chr8:91681699 NA -0.79 -13.27 -0.59 1.48e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs56176327 0.600 rs7628207 chr3:49754970 T/C cg21659725 chr3:3221576 CRBN -0.65 -7.73 -0.39 1.25e-13 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.629 rs13031508 chr2:100952757 A/G cg08017756 chr2:100939284 LONRF2 -0.45 -8.41 -0.42 1.24e-15 Intelligence (multi-trait analysis); LUSC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg25358565 chr5:93447407 FAM172A -1.11 -12.91 -0.58 3.35e-31 Diabetic retinopathy; LUSC cis rs4356932 1.000 rs7377856 chr4:76964096 T/C cg00809888 chr4:76862425 NAAA 0.36 6.0 0.31 5.07e-9 Blood protein levels; LUSC trans rs7615952 0.551 rs6438945 chr3:125634473 G/A cg07211511 chr3:129823064 LOC729375 -1.24 -18.99 -0.72 4.75e-55 Blood pressure (smoking interaction); LUSC cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs7827290 0.863 rs7014099 chr8:142305766 C/T cg22052514 chr8:142401722 NA 0.37 5.68 0.3 2.92e-8 Bipolar disorder; LUSC cis rs2692947 0.770 rs62153678 chr2:96558346 C/T cg22654517 chr2:96458247 NA 0.37 6.92 0.35 2.38e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg16743903 chr16:89593216 SPG7 -0.38 -5.82 -0.3 1.42e-8 Multiple myeloma (IgH translocation); LUSC cis rs6582630 0.638 rs12425379 chr12:38523705 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.3 -0.41 2.56e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs1580019 0.961 rs4460271 chr7:32496503 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.81 0.54 3.97e-27 Cognitive ability; LUSC cis rs208520 0.690 rs12213561 chr6:66705646 T/C cg07460842 chr6:66804631 NA 1.08 16.95 0.68 6.24e-47 Exhaled nitric oxide output; LUSC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 13.4 0.59 4.64e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1814175 0.654 rs7482446 chr11:49779020 A/G cg15704280 chr7:45808275 SEPT13 -1.1 -22.92 -0.78 1.56e-70 Height; LUSC cis rs2708977 1.000 rs13029764 chr2:97328874 C/T cg01950434 chr2:97203154 ARID5A -0.57 -8.93 -0.44 2.95e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg03517284 chr6:25882590 NA -0.65 -11.44 -0.53 8.81e-26 Blood metabolite levels; LUSC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg08439880 chr3:133502540 NA -0.31 -5.65 -0.3 3.36e-8 Iron status biomarkers; LUSC cis rs483180 0.512 rs612430 chr1:120216025 A/G cg19096424 chr1:120255104 PHGDH 0.5 6.78 0.35 5.43e-11 Macular telangiectasia type 2; LUSC cis rs9815354 0.627 rs80120812 chr3:42021760 C/T cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs11676348 0.772 rs7422358 chr2:218952778 C/T cg00012203 chr2:219082015 ARPC2 -0.5 -7.78 -0.39 8.99e-14 Ulcerative colitis; LUSC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg21862992 chr11:68658383 NA 0.5 7.95 0.4 2.82e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7605827 0.930 rs2380657 chr2:15678482 T/C cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.27e-17 Educational attainment (years of education); LUSC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs9815354 0.680 rs73071354 chr3:41829186 C/A cg03022575 chr3:42003672 ULK4 0.85 8.62 0.43 2.78e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs40363 1.000 rs1690443 chr16:3517787 C/G cg05754148 chr16:3507555 NAT15 0.81 9.85 0.47 2.96e-20 Tuberculosis; LUSC cis rs1113500 0.933 rs10881500 chr1:108638895 C/T cg11967332 chr1:108735228 SLC25A24 0.39 5.93 0.31 7.44e-9 Growth-regulated protein alpha levels; LUSC cis rs4704187 0.687 rs2335136 chr5:74407994 T/C cg03227963 chr5:74354835 NA 0.32 6.87 0.35 3.09e-11 Response to amphetamines; LUSC cis rs554111 0.656 rs10916891 chr1:21199974 A/C cg01072550 chr1:21505969 NA 0.4 6.21 0.32 1.56e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC trans rs12439619 0.810 rs28876157 chr15:82509049 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.47 -6.37 -0.33 6.24e-10 Intelligence (multi-trait analysis); LUSC cis rs6582630 0.679 rs7301806 chr12:38596667 G/A cg13010199 chr12:38710504 ALG10B 0.48 7.28 0.37 2.47e-12 Drug-induced liver injury (flucloxacillin); LUSC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11644478 chr21:40555479 PSMG1 -0.65 -10.04 -0.48 6.66e-21 Menarche (age at onset); LUSC cis rs4499344 0.531 rs863905 chr19:33146403 T/C cg22980127 chr19:33182716 NUDT19 -0.43 -6.39 -0.33 5.7e-10 Mean platelet volume; LUSC cis rs11190604 1.000 rs10883501 chr10:102238326 A/G cg07080220 chr10:102295463 HIF1AN 0.64 8.46 0.42 8.25e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg10523679 chr1:76189770 ACADM 0.89 14.3 0.62 1.64e-36 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs500891 0.818 rs983140 chr6:84103896 T/A cg08257003 chr6:84140564 ME1 0.33 6.72 0.35 7.85e-11 Platelet-derived growth factor BB levels; LUSC cis rs9814567 1.000 rs3846055 chr3:134203973 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.4 -0.59 4.55e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.55 -0.34 2.2e-10 Alzheimer's disease (late onset); LUSC cis rs4909189 0.957 rs71547528 chr7:158135431 T/C cg06219351 chr7:158114137 PTPRN2 -0.54 -8.37 -0.42 1.65e-15 Response to amphetamines; LUSC cis rs78545713 0.649 rs41266811 chr6:26216656 T/C cg23601095 chr6:26197514 HIST1H3D 0.66 5.79 0.3 1.64e-8 Iron status biomarkers (total iron binding capacity); LUSC trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg03929089 chr4:120376271 NA 0.81 11.38 0.53 1.37e-25 Coronary artery disease; LUSC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg06484146 chr7:12443880 VWDE -0.69 -7.35 -0.37 1.53e-12 Coronary artery disease; LUSC cis rs6121246 0.609 rs1009453 chr20:30404840 C/G cg13852791 chr20:30311386 BCL2L1 0.9 13.34 0.59 7.48e-33 Mean corpuscular hemoglobin; LUSC cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs7267979 0.966 rs2500417 chr20:25383287 A/G cg03522245 chr20:25566470 NINL -0.35 -5.72 -0.3 2.36e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1003719 0.788 rs4572679 chr21:38453227 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.41 0.53 1.1e-25 Eye color traits; LUSC cis rs17661538 0.504 rs11598236 chr10:18451884 C/T cg03634479 chr10:18430412 CACNB2 -0.63 -6.05 -0.31 3.92e-9 Response to antipsychotic treatment; LUSC cis rs4947962 0.590 rs6969537 chr7:55082418 C/T cg23757825 chr7:55092271 EGFR -0.67 -8.76 -0.43 1.01e-16 Subjective response to lithium treatment; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg12564285 chr5:131593104 PDLIM4 0.44 7.92 0.4 3.48e-14 Breast cancer; LUSC cis rs9796 0.870 rs2306083 chr15:41347658 C/T cg18705301 chr15:41695430 NDUFAF1 -0.41 -7.18 -0.37 4.46e-12 Menopause (age at onset); LUSC cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.46 7.85 0.39 5.78e-14 Axial length; LUSC cis rs12541635 1.000 rs12541635 chr8:107090000 C/T cg10147462 chr8:107024639 NA -0.48 -8.76 -0.43 1.03e-16 Age of smoking initiation; LUSC cis rs3020736 0.500 rs4147641 chr22:42482502 C/G cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg18876405 chr7:65276391 NA -0.59 -9.63 -0.47 1.56e-19 Aortic root size; LUSC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg08219700 chr8:58056026 NA 0.69 7.91 0.4 3.7e-14 Developmental language disorder (linguistic errors); LUSC cis rs9326248 0.581 rs6589582 chr11:116829200 A/C cg01368799 chr11:117014884 PAFAH1B2 0.6 9.24 0.45 2.99e-18 Blood protein levels; LUSC trans rs7980799 0.682 rs7303356 chr12:33633599 C/G cg13010199 chr12:38710504 ALG10B -0.4 -5.97 -0.31 6.16e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg08962590 chr3:180631158 FXR1 0.35 6.09 0.32 3.03e-9 Tuberculosis; LUSC cis rs1005224 0.889 rs9323617 chr14:76158638 A/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.68 -9.38 -0.46 1.04e-18 Large artery stroke; LUSC cis rs12908161 1.000 rs34570071 chr15:85280212 T/A cg17173187 chr15:85201210 NMB 0.5 9.31 0.45 1.77e-18 Schizophrenia; LUSC trans rs12579753 1.000 rs12830268 chr12:82233627 A/C cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg23029597 chr12:123009494 RSRC2 -0.73 -9.73 -0.47 7.55e-20 Body mass index; LUSC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg27572855 chr1:25598939 RHD 0.43 7.5 0.38 5.96e-13 Plateletcrit;Mean corpuscular volume; LUSC cis rs1322639 0.806 rs1322640 chr6:169586887 T/C cg04662567 chr6:169592167 NA 0.41 6.18 0.32 1.82e-9 Pulse pressure; LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13012494 chr21:47604986 C21orf56 0.48 7.28 0.37 2.34e-12 Testicular germ cell tumor; LUSC cis rs11690935 0.550 rs62183784 chr2:172866696 A/G cg13550731 chr2:172543902 DYNC1I2 0.53 7.96 0.4 2.7e-14 Schizophrenia; LUSC cis rs9372253 1.000 rs9386894 chr6:110718853 A/G cg19196401 chr6:110721138 DDO -0.45 -8.49 -0.42 7.05e-16 Platelet distribution width; LUSC cis rs6430585 0.528 rs309159 chr2:136684940 C/T cg07169764 chr2:136633963 MCM6 1.09 16.97 0.68 5.21e-47 Corneal structure; LUSC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs2228479 0.541 rs62052173 chr16:89950739 T/C cg00800038 chr16:89945340 TCF25 -0.63 -6.68 -0.34 1.02e-10 Skin colour saturation; LUSC cis rs155076 1.000 rs155076 chr13:21870114 A/G cg14456004 chr13:21872349 NA -1.14 -15.66 -0.65 7.98e-42 White matter hyperintensity burden; LUSC cis rs7523050 0.643 rs12752417 chr1:109400639 A/C cg08274380 chr1:109419600 GPSM2 -1.16 -10.07 -0.48 5.09e-21 Fat distribution (HIV); LUSC trans rs1994135 0.692 rs7297538 chr12:33693438 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.53 0.46 3.28e-19 Resting heart rate; LUSC cis rs1448094 0.842 rs10863155 chr12:86446416 T/C cg00310523 chr12:86230176 RASSF9 -0.35 -6.2 -0.32 1.68e-9 Major depressive disorder; LUSC cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg26384229 chr12:38710491 ALG10B 0.63 10.04 0.48 6.9299999999999992e-21 Morning vs. evening chronotype; LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.4 6.18 0.32 1.89e-9 Menopause (age at onset); LUSC cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg22782873 chr19:19639568 YJEFN3 -0.5 -6.24 -0.32 1.3e-9 Bipolar disorder; LUSC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg12292205 chr6:26970375 C6orf41 0.68 11.53 0.53 4.12e-26 Autism spectrum disorder or schizophrenia; LUSC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg22800045 chr5:56110881 MAP3K1 -0.62 -8.56 -0.42 4.14e-16 Initial pursuit acceleration; LUSC cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg11502198 chr6:26597334 ABT1 0.67 10.6 0.5 8.06e-23 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg01028140 chr2:1542097 TPO -0.6 -8.21 -0.41 5.04e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC trans rs629535 0.814 rs62513376 chr8:70086881 C/T cg21567404 chr3:27674614 NA -0.97 -15.56 -0.65 1.92e-41 Dupuytren's disease; LUSC cis rs9473147 0.543 rs9367279 chr6:47448336 A/G cg02130027 chr6:47444894 CD2AP 0.35 5.67 0.3 3.01e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.96 17.35 0.69 1.59e-48 Chronic sinus infection; LUSC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.99 0.4 2.24e-14 Prudent dietary pattern; LUSC cis rs9905704 0.718 rs4793953 chr17:56613104 C/G cg19466818 chr17:56409534 MIR142 0.34 6.45 0.33 3.98e-10 Testicular germ cell tumor; LUSC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.4 6.15 0.32 2.2e-9 Platelet count; LUSC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4474465 0.833 rs10793317 chr11:78212011 G/A cg27205649 chr11:78285834 NARS2 0.51 5.86 0.31 1.13e-8 Alzheimer's disease (survival time); LUSC cis rs2932538 0.922 rs7535636 chr1:113101799 C/T cg22162597 chr1:113214053 CAPZA1 -0.68 -9.87 -0.48 2.54e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg12310025 chr6:25882481 NA -0.5 -9.09 -0.45 9.27e-18 Blood metabolite levels; LUSC cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg09184832 chr6:79620586 NA -0.43 -6.88 -0.35 3.06e-11 Intelligence (multi-trait analysis); LUSC cis rs4285028 0.699 rs1344279 chr3:121615679 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.8 -10.63 -0.5 6.5e-23 Multiple sclerosis; LUSC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg22535103 chr8:58192502 C8orf71 -0.65 -7.05 -0.36 1.01e-11 Developmental language disorder (linguistic errors); LUSC cis rs34779708 0.897 rs9665538 chr10:35461038 T/C cg03585969 chr10:35415529 CREM 0.61 9.2 0.45 4.12e-18 Inflammatory bowel disease;Crohn's disease; LUSC trans rs9929218 1.000 rs4500718 chr16:68754312 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.95 -0.55 1.18e-27 Colorectal cancer; LUSC cis rs7605827 0.930 rs6760888 chr2:15537863 T/C cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg12698349 chr2:225449008 CUL3 0.71 9.22 0.45 3.37e-18 IgE levels in asthmatics (D.p. specific); LUSC cis rs11958404 0.860 rs72816577 chr5:157431806 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg01448562 chr3:133502909 NA -0.66 -10.77 -0.51 2.06e-23 Iron status biomarkers; LUSC trans rs6502050 0.871 rs8080366 chr17:80067298 A/G cg07393940 chr7:158741817 NA -0.37 -6.49 -0.33 3.18e-10 Life satisfaction; LUSC cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.48 0.38 6.57e-13 Motion sickness; LUSC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg09796270 chr17:17721594 SREBF1 0.4 6.78 0.35 5.58e-11 Total body bone mineral density; LUSC cis rs8077889 0.826 rs60085355 chr17:41847415 T/C cg26893861 chr17:41843967 DUSP3 0.88 13.37 0.59 6.01e-33 Triglycerides; LUSC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -7.61 -0.38 2.77e-13 Developmental language disorder (linguistic errors); LUSC cis rs34779708 0.931 rs13376801 chr10:35370443 T/C cg03585969 chr10:35415529 CREM 0.59 8.83 0.44 6.06e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs5769765 1.000 rs738711 chr22:50282603 A/G cg26441486 chr22:50317300 CRELD2 -0.54 -8.21 -0.41 4.86e-15 Schizophrenia; LUSC cis rs11098499 1.000 rs13116504 chr4:120209412 A/C cg24375607 chr4:120327624 NA 0.74 11.2 0.52 6.18e-25 Corneal astigmatism; LUSC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg01097406 chr16:89675127 NA -0.34 -6.81 -0.35 4.55e-11 Vitiligo; LUSC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg18904891 chr8:8559673 CLDN23 0.62 8.59 0.43 3.27e-16 Obesity-related traits; LUSC trans rs12210905 0.925 rs12190201 chr6:27001458 A/C cg11837749 chr1:55047332 ACOT11 0.58 6.2 0.32 1.62e-9 Hip circumference adjusted for BMI; LUSC cis rs11098499 0.909 rs10026736 chr4:120384322 G/C cg24375607 chr4:120327624 NA 0.79 11.49 0.53 5.43e-26 Corneal astigmatism; LUSC cis rs4363385 0.510 rs11590369 chr1:152903603 G/C cg25856811 chr1:152973957 SPRR3 -0.39 -6.36 -0.33 6.76e-10 Inflammatory skin disease; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg04210991 chr1:226374609 ACBD3 0.45 6.1 0.32 2.9e-9 Mosquito bite size; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg27069263 chr2:55278118 RTN4 0.38 6.2 0.32 1.71e-9 Tuberculosis; LUSC cis rs6736093 0.796 rs13001162 chr2:112805997 C/T cg12686935 chr2:112915763 FBLN7 -0.4 -6.35 -0.33 7.12e-10 Coronary artery disease; LUSC cis rs1799949 0.602 rs8176199 chr17:41230524 T/G cg25072359 chr17:41440525 NA 0.66 8.18 0.41 5.99e-15 Menopause (age at onset); LUSC cis rs6967385 0.583 rs1116972 chr7:12348307 A/C cg06484146 chr7:12443880 VWDE 0.41 6.21 0.32 1.53e-9 Response to taxane treatment (placlitaxel); LUSC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg05872129 chr22:39784769 NA -0.6 -10.25 -0.49 1.3e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2692947 0.683 rs1813381 chr2:96422939 C/T cg22654517 chr2:96458247 NA -0.33 -6.0 -0.31 5.19e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg14584255 chr6:163149320 PACRG;PARK2 -0.4 -7.93 -0.4 3.41e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2204008 0.678 rs61929520 chr12:38446800 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.47 -0.33 3.41e-10 Bladder cancer; LUSC cis rs2073300 1.000 rs6132623 chr20:23442324 T/A cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12410462 0.502 rs115241368 chr1:227795465 A/G cg10327440 chr1:227177885 CDC42BPA -0.73 -6.23 -0.32 1.41e-9 Major depressive disorder; LUSC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg17724175 chr1:150552817 MCL1 0.37 6.63 0.34 1.34e-10 Tonsillectomy; LUSC cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs921968 0.643 rs3932856 chr2:219320207 C/A cg02176678 chr2:219576539 TTLL4 0.63 11.43 0.53 8.94e-26 Mean corpuscular hemoglobin concentration; LUSC cis rs1728785 0.901 rs11642189 chr16:68583990 G/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.82 -0.3 1.42e-8 Ulcerative colitis; LUSC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg22166914 chr1:53195759 ZYG11B 0.61 10.07 0.48 5.44e-21 Monocyte count; LUSC cis rs3743104 0.510 rs16973303 chr15:33020928 A/C cg07179000 chr15:33023586 GREM1 -0.35 -6.77 -0.35 5.64e-11 Hypospadias; LUSC cis rs859767 0.501 rs10193171 chr2:135403199 C/T cg12500956 chr2:135428796 TMEM163 0.28 6.51 0.34 2.72e-10 Neuroticism; LUSC cis rs11958404 0.932 rs7711898 chr5:157430688 A/G cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs4805272 0.512 rs4805278 chr19:29336664 C/T cg04546413 chr19:29218101 NA 0.58 7.22 0.37 3.57e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs4631830 0.720 rs2611512 chr10:51515534 A/G cg20129853 chr10:51489980 NA -0.34 -7.04 -0.36 1.07e-11 Prostate-specific antigen levels; LUSC cis rs10484885 0.553 rs72911820 chr6:90281934 G/A cg13799429 chr6:90582589 CASP8AP2 -0.55 -5.67 -0.3 3.03e-8 QRS interval (sulfonylurea treatment interaction); LUSC cis rs477692 1.000 rs538969 chr10:131410608 C/T cg05714579 chr10:131428358 MGMT 0.53 7.68 0.39 1.76e-13 Response to temozolomide; LUSC cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg13256891 chr4:100009986 ADH5 -0.43 -6.0 -0.31 5.06e-9 Alcohol dependence; LUSC cis rs2710642 0.962 rs4671051 chr2:63032696 A/T cg17519650 chr2:63277830 OTX1 -0.45 -6.19 -0.32 1.75e-9 LDL cholesterol levels;LDL cholesterol; LUSC trans rs4714291 0.832 rs6936016 chr6:40097013 A/G cg02267698 chr19:7991119 CTXN1 -0.55 -8.25 -0.41 3.8e-15 Strep throat; LUSC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg25019033 chr10:957182 NA -0.53 -6.1 -0.32 2.91e-9 Eosinophil percentage of granulocytes; LUSC cis rs2880765 0.835 rs6496027 chr15:86049988 C/T cg13263323 chr15:86062960 AKAP13 -0.36 -5.89 -0.31 9.33e-9 Coronary artery disease; LUSC trans rs79976124 0.719 rs34488909 chr6:66637850 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 8.49 0.42 7.01e-16 Type 2 diabetes; LUSC cis rs921968 0.541 rs496674 chr2:219432569 G/A cg02176678 chr2:219576539 TTLL4 0.75 14.64 0.63 7.48e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs950169 0.810 rs62029594 chr15:84955252 T/C cg12863693 chr15:85201151 NMB 0.36 7.06 0.36 9.44e-12 Schizophrenia; LUSC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg18876405 chr7:65276391 NA -0.7 -12.19 -0.56 1.54e-28 Aortic root size; LUSC cis rs4423214 0.559 rs11234042 chr11:71239086 C/A cg05163923 chr11:71159392 DHCR7 -0.69 -7.02 -0.36 1.26e-11 Vitamin D levels; LUSC cis rs77216612 0.835 rs56692845 chr12:12887811 C/T cg04607235 chr12:12878440 APOLD1 -0.94 -15.44 -0.65 5.89e-41 Lymphocyte counts; LUSC cis rs977987 0.843 rs10514396 chr16:75422903 T/C cg04384234 chr16:75411784 CFDP1 -0.46 -7.65 -0.39 2.21e-13 Dupuytren's disease; LUSC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg12463550 chr7:65579703 CRCP -0.56 -8.43 -0.42 1.02e-15 Aortic root size; LUSC cis rs6977660 0.943 rs10249996 chr7:19844935 G/A cg07541023 chr7:19748670 TWISTNB 0.53 6.07 0.32 3.48e-9 Thyroid stimulating hormone; LUSC cis rs11098499 0.738 rs28687057 chr4:120280812 A/G cg09307838 chr4:120376055 NA 0.69 10.35 0.49 5.71e-22 Corneal astigmatism; LUSC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg22535103 chr8:58192502 C8orf71 -0.56 -6.65 -0.34 1.18e-10 Developmental language disorder (linguistic errors); LUSC cis rs17401966 1.000 rs11121533 chr1:10292888 G/C cg19773385 chr1:10388646 KIF1B -0.54 -8.42 -0.42 1.11e-15 Hepatocellular carcinoma; LUSC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg24838063 chr12:130822603 PIWIL1 0.69 10.79 0.51 1.69e-23 Menopause (age at onset); LUSC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.16 16.54 0.67 2.7e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6542838 0.702 rs4851167 chr2:99496303 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.08 -0.32 3.22e-9 Fear of minor pain; LUSC cis rs2274273 0.870 rs10147434 chr14:55674847 C/T cg04306507 chr14:55594613 LGALS3 0.58 13.44 0.59 3.15e-33 Protein biomarker; LUSC cis rs1448094 0.967 rs2405789 chr12:86320466 C/T cg02569458 chr12:86230093 RASSF9 -0.42 -6.75 -0.35 6.7e-11 Major depressive disorder; LUSC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg11645453 chr3:52864694 ITIH4 -0.56 -13.3 -0.59 1.14e-32 Schizophrenia; LUSC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.17 0.41 6.27e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1461503 0.966 rs10790545 chr11:122838350 G/C cg27398637 chr11:122830231 C11orf63 -0.4 -6.34 -0.33 7.32e-10 Menarche (age at onset); LUSC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg00579200 chr11:133705235 NA -0.39 -5.68 -0.3 2.93e-8 Childhood ear infection; LUSC cis rs9486719 1.000 rs11153064 chr6:97021959 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.98 -0.48 1.1e-20 Migraine;Coronary artery disease; LUSC cis rs17270561 0.609 rs4712957 chr6:25719814 C/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.9 0.44 3.71e-17 Iron status biomarkers; LUSC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 8.09e-16 Aortic root size; LUSC cis rs6840360 1.000 rs10049991 chr4:152664163 A/T cg22705602 chr4:152727874 NA -0.27 -5.66 -0.3 3.26e-8 Intelligence (multi-trait analysis); LUSC cis rs757278 0.591 rs10266116 chr7:117304459 T/C cg10524701 chr7:117356490 CTTNBP2 0.4 5.76 0.3 1.9e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs1223397 0.938 rs34505804 chr6:13292514 G/A cg13974761 chr1:152670598 LCE2A 0.38 6.11 0.32 2.79e-9 Blood pressure; LUSC cis rs9457247 0.515 rs2757039 chr6:167370353 G/T cg23791538 chr6:167370224 RNASET2 0.54 9.07 0.44 1.01e-17 Crohn's disease; LUSC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11890956 chr21:40555474 PSMG1 1.04 21.28 0.76 3.93e-64 Cognitive function; LUSC cis rs9300255 0.739 rs4759417 chr12:123746510 C/T cg05973401 chr12:123451056 ABCB9 0.52 6.49 0.33 3.19e-10 Neutrophil percentage of white cells; LUSC trans rs1493916 0.805 rs1452648 chr18:31411003 G/T cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08704250 chr15:31115839 NA -0.48 -7.16 -0.36 5.21e-12 Huntington's disease progression; LUSC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg06713675 chr4:122721982 EXOSC9 -0.44 -7.77 -0.39 9.93e-14 Type 2 diabetes; LUSC cis rs427941 0.595 rs6465851 chr7:101827463 A/C cg06246474 chr7:101738831 CUX1 0.35 5.74 0.3 2.18e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC trans rs637571 0.522 rs606978 chr11:65711517 A/C cg17712092 chr4:129076599 LARP1B 0.8 11.88 0.55 2.11e-27 Eosinophil percentage of white cells; LUSC cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg21724239 chr8:58056113 NA -0.75 -8.3 -0.41 2.62e-15 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg05347473 chr6:146136440 FBXO30 -0.57 -9.85 -0.47 2.97e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs9436747 0.605 rs11587159 chr1:65987205 C/G cg14976592 chr1:65886160 LEPROT;LEPR -0.43 -5.88 -0.31 1.02e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs7107174 1.000 rs10899452 chr11:77995143 A/C cg02023728 chr11:77925099 USP35 0.48 6.61 0.34 1.52e-10 Testicular germ cell tumor; LUSC cis rs1712517 0.838 rs1891293 chr10:105001797 C/T cg05636881 chr10:105038444 INA -0.43 -7.17 -0.37 4.98e-12 Migraine; LUSC cis rs7089973 0.523 rs61869297 chr10:116779005 G/C cg23260525 chr10:116636907 FAM160B1 0.32 6.24 0.32 1.35e-9 Bipolar disorder or attention deficit hyperactivity disorder; LUSC trans rs62238980 0.614 rs4821006 chr22:32370060 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs12681287 0.640 rs12544463 chr8:87481114 A/G cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.36 6.24e-12 Caudate activity during reward; LUSC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg03563238 chr19:33554763 RHPN2 0.35 5.65 0.3 3.48e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2742417 1.000 rs2742436 chr3:45741397 T/C cg09608765 chr3:45636137 LIMD1 -0.37 -7.42 -0.38 9.67e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg13390004 chr1:15929781 NA 0.42 7.0 0.36 1.43e-11 Systolic blood pressure; LUSC cis rs6696846 0.691 rs11240370 chr1:205118336 T/G cg00857998 chr1:205179979 DSTYK 0.66 10.59 0.5 8.42e-23 Red blood cell count; LUSC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg06238570 chr21:40685208 BRWD1 -0.58 -9.0 -0.44 1.78e-17 Menarche (age at onset); LUSC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg15704280 chr7:45808275 SEPT13 1.03 17.61 0.69 1.42e-49 Coronary artery disease; LUSC trans rs330048 0.545 rs11249913 chr8:9143521 G/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.08 -0.32 3.19e-9 Systemic lupus erythematosus; LUSC cis rs11098499 0.754 rs28652763 chr4:120242312 C/T cg09307838 chr4:120376055 NA 0.69 10.49 0.5 1.93e-22 Corneal astigmatism; LUSC trans rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.75 -13.65 -0.6 5.14e-34 Brugada syndrome; LUSC cis rs2840044 1.000 rs225262 chr17:33959697 A/G cg05299278 chr17:33885742 SLFN14 0.3 6.14 0.32 2.29e-9 Response to radiotherapy in cancer (late toxicity); LUSC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.23e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg12463550 chr7:65579703 CRCP 0.45 6.74 0.35 6.98e-11 Aortic root size; LUSC cis rs4588572 0.643 rs1560195 chr5:77701913 A/G cg11547950 chr5:77652471 NA 0.51 7.37 0.37 1.33e-12 Triglycerides; LUSC cis rs6060717 0.536 rs6060670 chr20:34481143 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -5.67 -0.3 3.14e-8 Hip circumference adjusted for BMI; LUSC cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg06108461 chr20:60628389 TAF4 -0.93 -15.59 -0.65 1.53e-41 Body mass index; LUSC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg13319975 chr6:146136371 FBXO30 -0.71 -10.79 -0.51 1.81e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs2408955 0.521 rs10875753 chr12:48557141 C/T cg24011408 chr12:48396354 COL2A1 0.39 5.8 0.3 1.54e-8 Glycated hemoglobin levels; LUSC cis rs1451375 0.583 rs11575320 chr7:50605298 A/G cg18232548 chr7:50535776 DDC -0.56 -7.46 -0.38 7.72e-13 Malaria; LUSC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg03352830 chr11:487213 PTDSS2 0.75 8.72 0.43 1.37e-16 Body mass index; LUSC trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg23505145 chr19:12996616 KLF1 0.65 11.09 0.52 1.57e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg00522288 chr12:125625016 AACS -0.33 -6.2 -0.32 1.62e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg25319279 chr11:5960081 NA -0.41 -5.78 -0.3 1.68e-8 DNA methylation (variation); LUSC cis rs80282103 0.618 rs1079390 chr10:1161653 C/A cg18964960 chr10:1102726 WDR37 0.7 5.84 0.3 1.22e-8 Glomerular filtration rate (creatinine); LUSC cis rs2179367 0.600 rs111564088 chr6:149765782 G/A cg07828024 chr6:149772892 ZC3H12D -0.34 -5.69 -0.3 2.72e-8 Dupuytren's disease; LUSC cis rs72781680 0.848 rs2339926 chr2:24045734 C/G cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs10193935 0.901 rs9789740 chr2:42486799 A/G cg27598129 chr2:42591480 NA -0.61 -8.3 -0.41 2.67e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs921968 0.565 rs12612395 chr2:219621642 G/C cg02176678 chr2:219576539 TTLL4 -0.57 -10.03 -0.48 7.16e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs28647808 0.881 rs28494844 chr9:136266188 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg15242686 chr22:24348715 GSTTP1 0.47 7.4 0.38 1.13e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg03233332 chr7:66118400 NA -0.41 -6.03 -0.31 4.28e-9 Aortic root size; LUSC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg13770153 chr20:60521292 NA -0.64 -8.92 -0.44 3.17e-17 Body mass index; LUSC cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg24642439 chr20:33292090 TP53INP2 0.43 6.16 0.32 2.07e-9 Height; LUSC trans rs17685 0.753 rs9691174 chr7:75790405 T/C cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs4729127 1.000 rs12665908 chr7:94010770 T/C cg14660007 chr13:78271894 SLAIN1 0.5 6.45 0.33 3.88e-10 Intelligence; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26005303 chr7:5821307 RNF216 -0.41 -6.0 -0.31 5.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8017423 0.967 rs2277517 chr14:90722778 G/A cg14092571 chr14:90743983 NA -0.36 -5.86 -0.31 1.11e-8 Mortality in heart failure; LUSC cis rs7829975 0.774 rs13259216 chr8:8673601 A/C cg06636001 chr8:8085503 FLJ10661 0.6 9.35 0.46 1.28e-18 Mood instability; LUSC cis rs7826238 0.524 rs2921055 chr8:8319342 C/A cg15556689 chr8:8085844 FLJ10661 0.67 11.08 0.52 1.7e-24 Systolic blood pressure; LUSC cis rs5769765 0.954 rs5770739 chr22:50268014 C/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.62 -0.34 1.45e-10 Schizophrenia; LUSC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.21 0.52 5.58e-25 Alzheimer's disease; LUSC cis rs17102884 0.506 rs4899540 chr14:75403408 G/A cg11812906 chr14:75593930 NEK9 -0.42 -6.34 -0.33 7.66e-10 Neuroticism; LUSC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.56 0.38 3.93e-13 Multiple sclerosis; LUSC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg22437258 chr11:111473054 SIK2 0.54 7.68 0.39 1.75e-13 Primary sclerosing cholangitis; LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg00149659 chr3:10157352 C3orf10 1.0 14.77 0.63 2.33e-38 Alzheimer's disease; LUSC cis rs9527 0.590 rs1926029 chr10:104855670 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.48 0.46 4.82e-19 Arsenic metabolism; LUSC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC trans rs10506458 0.834 rs12426893 chr12:63388120 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.17 -14.8 -0.63 1.76e-38 Hemostatic factors and hematological phenotypes; LUSC trans rs12210905 0.688 rs12212389 chr6:27326397 T/C cg02699829 chr19:13216355 TRMT1 -0.56 -6.23 -0.32 1.39e-9 Hip circumference adjusted for BMI; LUSC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.6 0.54 2.33e-26 Prudent dietary pattern; LUSC trans rs11700980 0.551 rs11701765 chr21:30115651 C/T cg14791747 chr16:20752902 THUMPD1 -0.58 -6.28 -0.32 1.05e-9 QRS complex (12-leadsum); LUSC cis rs7267979 1.000 rs6083844 chr20:25386832 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.45 -0.33 3.88e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12681287 0.752 rs12677470 chr8:87260559 G/A cg27223183 chr8:87520930 FAM82B -0.45 -5.72 -0.3 2.33e-8 Caudate activity during reward; LUSC cis rs4969178 0.965 rs2292642 chr17:76395430 C/T cg20026190 chr17:76395443 PGS1 0.46 8.2 0.41 5.16e-15 HDL cholesterol levels; LUSC cis rs34330 0.562 rs11055025 chr12:12866619 A/T cg09462578 chr12:12878428 APOLD1 -0.62 -7.29 -0.37 2.31e-12 Systemic lupus erythematosus; LUSC cis rs6121246 0.567 rs6060262 chr20:30193071 A/C cg13852791 chr20:30311386 BCL2L1 0.72 8.29 0.41 2.73e-15 Mean corpuscular hemoglobin; LUSC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg08859206 chr1:53392774 SCP2 0.47 7.88 0.4 4.71e-14 Monocyte count; LUSC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg16386425 chr10:429943 DIP2C 0.44 7.21 0.37 3.82e-12 Psychosis in Alzheimer's disease; LUSC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg03264133 chr6:25882463 NA -0.55 -9.14 -0.45 6.18e-18 Intelligence (multi-trait analysis); LUSC cis rs3784262 0.512 rs4646571 chr15:58343137 T/C cg12031962 chr15:58353849 ALDH1A2 -0.36 -6.58 -0.34 1.86e-10 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs17270561 0.609 rs4712961 chr6:25727334 C/T cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.49 6.85 0.35 3.59e-11 Multiple sclerosis; LUSC cis rs9326248 0.581 rs10790167 chr11:116800943 T/C cg20608306 chr11:116969690 SIK3 0.36 6.69 0.34 9.29e-11 Blood protein levels; LUSC cis rs34172651 0.876 rs2547033 chr16:24743657 C/T cg00339695 chr16:24857497 SLC5A11 0.39 6.98 0.36 1.62e-11 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg14092988 chr3:52407081 DNAH1 0.32 6.34 0.33 7.4e-10 Bipolar disorder; LUSC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg12310025 chr6:25882481 NA -0.5 -8.59 -0.43 3.48e-16 Intelligence (multi-trait analysis); LUSC cis rs7903847 0.656 rs11189208 chr10:99169172 C/G cg20016023 chr10:99160130 RRP12 -0.25 -5.78 -0.3 1.69e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs514406 0.800 rs4926930 chr1:53217335 A/G cg01802117 chr1:53393560 SCP2 0.37 6.0 0.31 5.15e-9 Monocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16878075 chr8:145050837 PLEC1 -0.4 -6.19 -0.32 1.8e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg13944838 chr5:179740914 GFPT2 -0.67 -10.77 -0.51 2.04e-23 Height; LUSC cis rs727505 1.000 rs56321835 chr7:124529622 T/C cg23710748 chr7:124431027 NA -0.42 -7.42 -0.38 1e-12 Lewy body disease; LUSC cis rs1322512 0.917 rs2800629 chr6:153007917 A/C cg27316956 chr6:152958899 SYNE1 0.36 6.12 0.32 2.57e-9 Tonometry; LUSC cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.69 0.83 1.71e-88 Chronic sinus infection; LUSC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg21724239 chr8:58056113 NA 0.56 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); LUSC cis rs453301 0.606 rs7462373 chr8:8899318 G/C cg15556689 chr8:8085844 FLJ10661 -0.6 -9.25 -0.45 2.68e-18 Joint mobility (Beighton score); LUSC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg13319975 chr6:146136371 FBXO30 -0.53 -8.1 -0.41 1.05e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7589342 0.566 rs11895542 chr2:106390429 G/A cg14210321 chr2:106509881 NCK2 -0.41 -5.94 -0.31 7.29e-9 Addiction; LUSC cis rs6867032 1.000 rs10462750 chr5:2012963 A/G cg26168224 chr5:2018326 NA 0.8 15.0 0.63 3.01e-39 Gut microbiome composition (winter); LUSC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg18240062 chr17:79603768 NPLOC4 0.79 15.24 0.64 3.35e-40 Eye color traits; LUSC cis rs4718428 0.924 rs6971897 chr7:66412774 T/A cg18252515 chr7:66147081 NA -0.38 -5.77 -0.3 1.82e-8 Corneal structure; LUSC trans rs62103177 0.608 rs4799115 chr18:77736365 A/T cg05926928 chr17:57297772 GDPD1 -0.96 -10.73 -0.51 2.9e-23 Opioid sensitivity; LUSC cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg05347473 chr6:146136440 FBXO30 0.47 7.75 0.39 1.1e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg07701084 chr6:150067640 NUP43 0.54 8.12 0.41 9.26e-15 Lung cancer; LUSC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg03264133 chr6:25882463 NA -0.38 -6.71 -0.34 8.45e-11 Height; LUSC cis rs8114671 0.805 rs6060168 chr20:33621017 C/T cg07148914 chr20:33460835 GGT7 0.48 7.17 0.37 4.83e-12 Height; LUSC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg03433033 chr1:76189801 ACADM -0.81 -13.1 -0.58 6.17e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg11050988 chr7:1952600 MAD1L1 -0.32 -6.04 -0.31 4.14e-9 Bipolar disorder and schizophrenia; LUSC cis rs1983891 0.955 rs6917029 chr6:41548540 C/G cg20194872 chr6:41519635 FOXP4 0.35 6.23 0.32 1.38e-9 Prostate cancer; LUSC cis rs79149102 0.579 rs12593542 chr15:75282147 C/G cg09165964 chr15:75287851 SCAMP5 -0.76 -6.87 -0.35 3.24e-11 Lung cancer; LUSC cis rs1577917 0.959 rs34258068 chr6:86679449 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.44 -0.42 9.55e-16 Response to antipsychotic treatment; LUSC cis rs295140 0.668 rs3769482 chr2:201173100 C/G cg04283868 chr2:201171347 SPATS2L 0.43 6.18 0.32 1.82e-9 QT interval; LUSC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg05425664 chr17:57184151 TRIM37 -0.56 -8.31 -0.41 2.44e-15 Intelligence (multi-trait analysis); LUSC trans rs6952808 1.000 rs4256490 chr7:1890764 G/A cg24247370 chr13:99142703 STK24 -0.33 -6.01 -0.31 4.74e-9 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.805 rs7296063 chr12:37964775 T/G cg13010199 chr12:38710504 ALG10B 0.7 10.85 0.51 1.1e-23 Bladder cancer; LUSC cis rs3770081 1.000 rs17618001 chr2:86289303 T/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg13628971 chr7:2884303 GNA12 0.44 6.01 0.31 4.77e-9 Height; LUSC cis rs4906332 1.000 rs17617832 chr14:103943140 T/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.15 -0.36 5.46e-12 Coronary artery disease; LUSC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg06815965 chr1:205818668 PM20D1 0.38 5.84 0.3 1.22e-8 Menarche (age at onset); LUSC cis rs9650657 0.645 rs9969657 chr8:10515278 A/G cg27411982 chr8:10470053 RP1L1 0.47 7.7 0.39 1.6e-13 Neuroticism; LUSC cis rs17401966 0.838 rs2182326 chr1:10385664 G/A cg19773385 chr1:10388646 KIF1B -0.49 -8.64 -0.43 2.45e-16 Hepatocellular carcinoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07600211 chr1:145516081 GNRHR2;PEX11B -0.51 -6.52 -0.34 2.55e-10 Bipolar disorder and schizophrenia; LUSC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg05802129 chr4:122689817 NA -0.52 -8.81 -0.43 6.92e-17 Type 2 diabetes; LUSC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg08859206 chr1:53392774 SCP2 0.47 7.84 0.39 6.27e-14 Monocyte count; LUSC cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg05340658 chr4:99064831 C4orf37 0.69 11.63 0.54 1.69e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.87 14.63 0.62 8.8e-38 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg18722847 chr3:44754129 ZNF502 -0.36 -5.71 -0.3 2.45e-8 Depressive symptoms; LUSC cis rs17286411 0.750 rs4788579 chr16:71951845 A/C cg03805757 chr16:71968109 PKD1L3 0.39 6.51 0.34 2.7e-10 Blood protein levels; LUSC cis rs2012796 0.957 rs7151434 chr14:81819468 A/G cg02996355 chr14:81879375 NA 0.46 6.67 0.34 1.08e-10 Night sleep phenotypes; LUSC cis rs734999 0.545 rs12730932 chr1:2559589 T/G cg18932078 chr1:2524107 MMEL1 -0.31 -6.9 -0.35 2.61e-11 Ulcerative colitis; LUSC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg04267008 chr7:1944627 MAD1L1 -0.59 -9.09 -0.45 8.83e-18 Bipolar disorder and schizophrenia; LUSC cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg27129171 chr3:47204927 SETD2 0.76 13.76 0.6 1.96e-34 Colorectal cancer; LUSC cis rs7829975 0.617 rs4841072 chr8:8791253 C/A cg06636001 chr8:8085503 FLJ10661 -0.54 -8.62 -0.43 2.71e-16 Mood instability; LUSC cis rs11155671 0.530 rs7768626 chr6:150207962 G/T cg09699651 chr6:150184138 LRP11 0.45 7.15 0.36 5.64e-12 Testicular germ cell tumor; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15620207 chr1:150207153 ANP32E -0.42 -6.14 -0.32 2.33e-9 Triglycerides; LUSC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg24531977 chr5:56204891 C5orf35 -0.89 -13.8 -0.6 1.31e-34 Initial pursuit acceleration; LUSC cis rs9303401 0.659 rs7223708 chr17:56896398 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.34 0.59 7.79e-33 Cognitive test performance; LUSC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg04539111 chr16:67997858 SLC12A4 -0.46 -6.26 -0.32 1.17e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg13535736 chr9:111863775 C9orf5 -0.43 -6.81 -0.35 4.43e-11 Menarche (age at onset); LUSC cis rs2991971 1.000 rs2991970 chr1:46011005 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.44 -0.33 4.09e-10 High light scatter reticulocyte count; LUSC trans rs3942852 0.869 rs4752806 chr11:48118199 G/C cg15704280 chr7:45808275 SEPT13 -0.54 -6.26 -0.32 1.21e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg23324259 chr8:82754387 SNX16 -0.43 -5.77 -0.3 1.85e-8 Diastolic blood pressure; LUSC cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg09904177 chr6:26538194 HMGN4 -0.73 -6.49 -0.33 3.11e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs1018697 1.000 rs4919677 chr10:104554304 G/A cg04362960 chr10:104952993 NT5C2 0.47 6.46 0.33 3.65e-10 Colorectal adenoma (advanced); LUSC cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg22681709 chr2:178499509 PDE11A -0.6 -11.78 -0.54 5.08e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.47 -6.9 -0.35 2.65e-11 Alzheimer's disease (late onset); LUSC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg00684032 chr4:1343700 KIAA1530 -0.35 -6.23 -0.32 1.44e-9 Obesity-related traits; LUSC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg11764359 chr7:65958608 NA -0.51 -6.6 -0.34 1.57e-10 Aortic root size; LUSC cis rs2985684 0.895 rs4900940 chr14:50075310 A/C cg04989706 chr14:50066350 PPIL5 -0.46 -5.83 -0.3 1.31e-8 Carotid intima media thickness; LUSC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg08742575 chr21:47604166 C21orf56 -0.46 -7.16 -0.36 5.09e-12 Testicular germ cell tumor; LUSC cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg18132916 chr6:79620363 NA -0.39 -5.99 -0.31 5.41e-9 Intelligence (multi-trait analysis); LUSC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg21248554 chr2:27665150 KRTCAP3 -0.31 -6.17 -0.32 2.03e-9 Menopause (age at onset); LUSC cis rs4443100 0.670 rs13054331 chr22:23407063 G/A cg14186256 chr22:23484241 RTDR1 0.54 6.98 0.36 1.64e-11 Serum parathyroid hormone levels; LUSC cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg13319975 chr6:146136371 FBXO30 0.49 7.37 0.37 1.35e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2979489 0.624 rs62505275 chr8:30437639 C/T cg26383811 chr8:30366931 RBPMS -0.43 -6.75 -0.35 6.4e-11 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC trans rs11039798 0.764 rs7294013 chr11:48762416 G/A cg15704280 chr7:45808275 SEPT13 0.81 7.73 0.39 1.27e-13 Axial length; LUSC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg09509183 chr1:209979624 IRF6 0.5 6.09 0.32 3.17e-9 Cleft lip with or without cleft palate; LUSC trans rs11098499 0.909 rs10020034 chr4:120294331 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.11 0.32 2.82e-9 Corneal astigmatism; LUSC trans rs7493138 0.967 rs4384536 chr14:28997083 C/A cg10573181 chr4:170533618 NEK1 0.41 6.03 0.31 4.25e-9 Longevity; LUSC cis rs8092503 1.000 rs12956208 chr18:52473167 C/T cg12377874 chr18:52495404 RAB27B 0.33 6.08 0.32 3.32e-9 Childhood body mass index; LUSC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg13883939 chr12:118541731 VSIG10 0.38 5.96 0.31 6.51e-9 Calcium levels; LUSC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.57 -0.5 1.04e-22 Alzheimer's disease; LUSC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg15145296 chr3:125709740 NA -0.58 -6.41 -0.33 4.9e-10 Blood pressure (smoking interaction); LUSC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.48 -6.87 -0.35 3.21e-11 Mean platelet volume; LUSC cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg05347473 chr6:146136440 FBXO30 0.59 10.32 0.49 7.62e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg21028142 chr17:79581711 NPLOC4 0.32 7.65 0.39 2.12e-13 Eye color traits; LUSC cis rs9660992 0.649 rs12128254 chr1:205268097 C/T cg21643547 chr1:205240462 TMCC2 -0.51 -9.43 -0.46 7.06e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1577917 0.559 rs1173418 chr6:86402916 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 5.68 0.3 2.92e-8 Response to antipsychotic treatment; LUSC cis rs4654899 0.965 rs61781115 chr1:21322860 C/T cg01072550 chr1:21505969 NA -0.55 -8.45 -0.42 9.03e-16 Superior frontal gyrus grey matter volume; LUSC cis rs2625529 0.557 rs7496582 chr15:72147831 T/G cg16672083 chr15:72433130 SENP8 -0.5 -8.22 -0.41 4.64e-15 Red blood cell count; LUSC cis rs6445967 0.530 rs12490706 chr3:58408247 C/T cg23715586 chr3:58305044 RPP14 -0.39 -6.31 -0.33 8.8e-10 Platelet count; LUSC cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.03 0.85 2.44e-93 Chronic sinus infection; LUSC cis rs2235649 0.828 rs9938694 chr16:1849872 T/C cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.11 -0.32 2.71e-9 Blood metabolite levels; LUSC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg25039879 chr17:56429692 SUPT4H1 0.67 8.85 0.44 5.03e-17 Cognitive test performance; LUSC cis rs2303282 0.664 rs4783938 chr16:56407023 G/A cg00500540 chr16:56394104 NA -0.4 -6.96 -0.36 1.78e-11 Breast cancer; LUSC cis rs1003719 0.715 rs35199609 chr21:38510262 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.81e-22 Eye color traits; LUSC cis rs733592 0.507 rs10747529 chr12:48473369 G/A cg24011408 chr12:48396354 COL2A1 -0.53 -8.72 -0.43 1.33e-16 Plateletcrit; LUSC cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg08999081 chr20:33150536 PIGU 0.53 10.54 0.5 1.31e-22 Glomerular filtration rate (creatinine); LUSC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg18876405 chr7:65276391 NA 0.68 11.59 0.54 2.5e-26 Aortic root size; LUSC cis rs2742417 1.000 rs2742385 chr3:45756270 G/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs17039065 1.000 rs75264077 chr4:109393185 T/G cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.65e-10 Gut microbiome composition (summer); LUSC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.35 5.75 0.3 2e-8 Menopause (age at onset); LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg18000306 chr6:288505 NA 0.34 6.47 0.33 3.52e-10 Menopause (age at onset); LUSC cis rs12701220 0.817 rs7798459 chr7:1087965 C/T cg00990874 chr7:1149470 C7orf50 -0.49 -6.53 -0.34 2.46e-10 Bronchopulmonary dysplasia; LUSC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg23262073 chr20:60523788 NA -0.43 -6.42 -0.33 4.79e-10 Body mass index; LUSC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg10018233 chr7:150070692 REPIN1 0.39 6.74 0.35 6.82e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs3772130 0.962 rs9856641 chr3:121566859 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 9.98 0.48 1.09e-20 Cognitive performance; LUSC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg16624210 chr5:671434 TPPP 0.47 5.92 0.31 8.21e-9 Lung disease severity in cystic fibrosis; LUSC cis rs9818941 0.826 rs2712321 chr3:157644344 C/T cg08654915 chr3:157813417 NA 0.27 6.32 0.33 8.51e-10 Height; LUSC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg01416388 chr22:39784598 NA -0.44 -7.34 -0.37 1.67e-12 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg05347473 chr6:146136440 FBXO30 0.65 11.01 0.52 3.01e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs3087591 0.881 rs2905804 chr17:29519995 T/C cg24425628 chr17:29625626 OMG;NF1 0.6 8.55 0.42 4.36e-16 Hip circumference; LUSC cis rs41307935 0.722 rs12724052 chr1:27234682 G/A cg12203394 chr1:27248618 NUDC 0.54 5.71 0.3 2.52e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg01206211 chr2:36825736 FEZ2 0.56 13.11 0.58 5.71e-32 Height; LUSC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg17173187 chr15:85201210 NMB 0.37 6.56 0.34 2.08e-10 Schizophrenia; LUSC trans rs61931739 0.612 rs2004961 chr12:33994599 A/G cg26384229 chr12:38710491 ALG10B 0.49 7.51 0.38 5.61e-13 Morning vs. evening chronotype; LUSC cis rs3198697 0.663 rs12928099 chr16:15150505 C/A cg27102117 chr16:15229624 NA 0.38 5.66 0.3 3.27e-8 Triglycerides; LUSC cis rs8028313 0.731 rs13380201 chr15:67973665 A/G cg27219399 chr15:67835830 MAP2K5 0.35 5.7 0.3 2.63e-8 Obesity; LUSC cis rs360798 0.532 rs12994674 chr2:62996645 G/A cg17519650 chr2:63277830 OTX1 -0.46 -6.21 -0.32 1.55e-9 Coronary artery disease; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg07157834 chr1:205819609 PM20D1 -0.43 -6.4 -0.33 5.32e-10 Menarche (age at onset); LUSC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg22823121 chr1:150693482 HORMAD1 0.57 8.85 0.44 5.33e-17 Tonsillectomy; LUSC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg09367891 chr1:107599246 PRMT6 0.51 7.86 0.4 5.26e-14 Facial morphology (factor 21, depth of nasal alae); LUSC trans rs3733585 0.631 rs4697925 chr4:10124330 G/C cg26043149 chr18:55253948 FECH -0.53 -7.63 -0.39 2.54e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg00530320 chr1:46809349 NSUN4 0.57 8.76 0.43 9.71e-17 Menopause (age at onset); LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.05 -0.31 3.89e-9 Platelet count; LUSC cis rs7107174 0.901 rs11237487 chr11:78126754 G/C cg02023728 chr11:77925099 USP35 0.42 6.2 0.32 1.63e-9 Testicular germ cell tumor; LUSC trans rs72674100 1.000 rs72882317 chr4:97991290 C/G cg16405019 chr1:18959625 PAX7 -0.63 -6.65 -0.34 1.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs9329221 0.710 rs11249995 chr8:10238922 T/C cg15556689 chr8:8085844 FLJ10661 0.62 8.98 0.44 2.09e-17 Neuroticism; LUSC cis rs7119 0.700 rs2867311 chr15:77902191 A/C cg27398640 chr15:77910606 LINGO1 0.38 8.85 0.44 5.14e-17 Type 2 diabetes; LUSC trans rs28647808 1.000 rs28591209 chr9:136259668 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs9399401 0.626 rs13198644 chr6:142783233 A/G cg03128060 chr6:142623767 GPR126 0.58 9.61 0.47 1.76e-19 Chronic obstructive pulmonary disease; LUSC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.46 -6.89 -0.35 2.77e-11 Alzheimer's disease (late onset); LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg07677032 chr17:61819896 STRADA 0.52 8.72 0.43 1.29e-16 Prudent dietary pattern; LUSC cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC cis rs9831754 0.906 rs9840031 chr3:78396140 C/T cg06138941 chr3:78371609 NA 0.66 9.23 0.45 3.25e-18 Calcium levels; LUSC cis rs1570884 0.516 rs2094108 chr13:50171550 G/A cg08779649 chr13:50194554 NA 0.4 6.89 0.35 2.85e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs12681287 0.608 rs2953511 chr8:87340870 G/A cg27223183 chr8:87520930 FAM82B -0.54 -7.08 -0.36 8.62e-12 Caudate activity during reward; LUSC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg25767906 chr1:53392781 SCP2 0.45 8.02 0.4 1.84e-14 Monocyte count; LUSC cis rs10791097 0.967 rs10791099 chr11:130718813 G/C cg12179176 chr11:130786555 SNX19 0.77 13.25 0.59 1.74e-32 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.82 -0.35 4.17e-11 Developmental language disorder (linguistic errors); LUSC cis rs929354 0.742 rs6956046 chr7:156962874 G/A cg17757837 chr7:157058334 UBE3C 0.83 13.33 0.59 8.46e-33 Body mass index; LUSC cis rs7605827 0.893 rs2098463 chr2:15512175 C/G cg19274914 chr2:15703543 NA 0.46 8.94 0.44 2.66e-17 Educational attainment (years of education); LUSC cis rs11649653 0.502 rs62057232 chr16:30820866 T/C cg02466173 chr16:30829666 NA 0.48 9.4 0.46 8.97e-19 Triglycerides; LUSC cis rs3768617 0.510 rs10752902 chr1:183090265 T/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs12681288 0.862 rs2701899 chr8:1019581 G/A cg15309053 chr8:964076 NA 0.32 6.27 0.32 1.13e-9 Schizophrenia; LUSC trans rs877282 0.853 rs7079299 chr10:756455 A/G cg22713356 chr15:30763199 NA 0.98 12.85 0.58 5.65e-31 Uric acid levels; LUSC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg18225595 chr11:63971243 STIP1 0.47 5.68 0.3 3.01e-8 Mean platelet volume; LUSC cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg00071950 chr4:10020882 SLC2A9 0.58 9.96 0.48 1.27e-20 Bone mineral density; LUSC cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg16325326 chr1:53192061 ZYG11B 0.71 11.6 0.54 2.19e-26 Monocyte count; LUSC cis rs17102423 0.594 rs1998688 chr14:65562306 C/G cg11161011 chr14:65562177 MAX 0.71 11.12 0.52 1.21e-24 Obesity-related traits; LUSC cis rs13253111 0.766 rs56232071 chr8:28063230 A/T cg26534493 chr8:28060551 NA 0.45 8.67 0.43 1.92e-16 Childhood body mass index; LUSC cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg05896524 chr21:47604654 C21orf56 0.5 7.18 0.37 4.54e-12 Testicular germ cell tumor; LUSC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg17173187 chr15:85201210 NMB 0.37 6.54 0.34 2.26e-10 Schizophrenia; LUSC cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg10978503 chr1:24200527 CNR2 0.49 11.17 0.52 7.73e-25 Immature fraction of reticulocytes; LUSC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg13390004 chr1:15929781 NA 0.4 6.74 0.35 7.14e-11 Systolic blood pressure; LUSC cis rs4356932 0.967 rs4859586 chr4:76943235 T/C cg00809888 chr4:76862425 NAAA 0.35 5.78 0.3 1.72e-8 Blood protein levels; LUSC cis rs12493885 0.818 rs10935970 chr3:153770237 C/G cg17054900 chr3:154042577 DHX36 -0.54 -5.8 -0.3 1.58e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg14784868 chr12:69753453 YEATS4 0.81 13.27 0.59 1.49e-32 Blood protein levels; LUSC cis rs950027 0.620 rs2486274 chr15:45666228 G/T cg26924012 chr15:45694286 SPATA5L1 0.78 12.41 0.56 2.5e-29 Response to fenofibrate (adiponectin levels); LUSC cis rs6977660 0.714 rs10270204 chr7:19819544 C/T cg05791153 chr7:19748676 TWISTNB 0.65 6.87 0.35 3.09e-11 Thyroid stimulating hormone; LUSC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg08949735 chr16:89699720 DPEP1 -0.24 -5.88 -0.31 9.91e-9 Vitiligo; LUSC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg01689657 chr7:91764605 CYP51A1 0.33 6.0 0.31 5.06e-9 Breast cancer; LUSC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg00339695 chr16:24857497 SLC5A11 0.6 9.48 0.46 5e-19 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg05347473 chr6:146136440 FBXO30 -0.48 -8.14 -0.41 8e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs35306767 0.903 rs11253504 chr10:956046 A/G cg25019033 chr10:957182 NA -0.55 -6.33 -0.33 8e-10 Eosinophil percentage of granulocytes; LUSC cis rs9653442 0.527 rs10176782 chr2:100782827 C/A cg07810366 chr2:100720526 AFF3 -0.44 -7.49 -0.38 6.12e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs11190604 0.767 rs10883489 chr10:102194532 T/C cg07080220 chr10:102295463 HIF1AN 0.61 8.14 0.41 8.11e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs983392 0.709 rs1820428 chr11:59986333 A/T cg24026212 chr11:59952134 MS4A6A -0.35 -6.1 -0.32 2.9e-9 Alzheimer's disease (late onset); LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.49 6.12 0.32 2.68e-9 Renal function-related traits (BUN); LUSC cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg01579765 chr21:45077557 HSF2BP -0.48 -10.13 -0.48 3.21e-21 Mean corpuscular volume; LUSC cis rs1371867 0.846 rs1660324 chr8:101281271 C/T cg06002616 chr8:101225028 SPAG1 -0.45 -7.39 -0.38 1.17e-12 Atrioventricular conduction; LUSC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg23158103 chr7:148848205 ZNF398 -0.46 -7.49 -0.38 6.07e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg05472934 chr7:22766657 IL6 0.5 7.84 0.39 6.13e-14 Lung cancer; LUSC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg24578937 chr1:2090814 PRKCZ -0.43 -9.56 -0.46 2.76e-19 Height; LUSC cis rs7809950 0.817 rs2237678 chr7:107203265 T/G cg23024343 chr7:107201750 COG5 -0.71 -10.29 -0.49 9.59e-22 Coronary artery disease; LUSC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 13.13 0.58 5.03e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg18252515 chr7:66147081 NA -1.21 -13.64 -0.6 5.65e-34 Diabetic kidney disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09311052 chr1:154531418 UBE2Q1 0.46 6.92 0.35 2.36e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg15445000 chr17:37608096 MED1 0.4 6.75 0.35 6.65e-11 Glomerular filtration rate (creatinine); LUSC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg06060754 chr5:176797920 RGS14 -0.75 -12.43 -0.56 2.08e-29 Hemoglobin concentration;Hematocrit; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07889337 chr17:38257022 NR1D1 -0.6 -7.69 -0.39 1.65e-13 Bipolar disorder and schizophrenia; LUSC cis rs854765 0.583 rs950966 chr17:17783748 A/G cg16928487 chr17:17741425 SREBF1 0.46 9.0 0.44 1.72e-17 Total body bone mineral density; LUSC cis rs4589502 1.000 rs8023363 chr15:67154654 G/A cg12317470 chr15:67143691 NA 0.6 5.89 0.31 9.43e-9 Lung cancer (smoking interaction); LUSC cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.44e-12 Motion sickness; LUSC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg12927641 chr6:109611667 NA -0.43 -7.62 -0.38 2.71e-13 Reticulocyte fraction of red cells; LUSC trans rs9329221 0.935 rs3750310 chr8:10283426 G/A cg08975724 chr8:8085496 FLJ10661 -0.47 -6.6 -0.34 1.57e-10 Neuroticism; LUSC cis rs1670533 1.000 rs6852850 chr4:1052857 C/G cg27284194 chr4:1044797 NA 0.59 8.96 0.44 2.37e-17 Recombination rate (females); LUSC cis rs4702 0.611 rs11539637 chr15:91428290 C/T cg05469396 chr15:91419421 FURIN 0.46 8.21 0.41 5.05e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6961069 0.585 rs13228738 chr7:80250811 C/T cg04458919 chr7:80252533 CD36 -0.37 -6.55 -0.34 2.12e-10 Platelet count; LUSC cis rs7208859 0.623 rs3794796 chr17:29130880 G/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.69 -0.3 2.74e-8 Developmental language disorder (linguistic errors); LUSC cis rs12579753 0.956 rs7965168 chr12:82184467 C/A cg07988820 chr12:82153109 PPFIA2 -0.42 -5.78 -0.3 1.68e-8 Resting heart rate; LUSC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg25039879 chr17:56429692 SUPT4H1 0.5 7.04 0.36 1.07e-11 Cognitive test performance; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.77 -10.35 -0.49 5.88e-22 Alzheimer's disease; LUSC cis rs61931739 0.571 rs4001689 chr12:34243271 C/T cg06521331 chr12:34319734 NA -0.46 -7.59 -0.38 3.28e-13 Morning vs. evening chronotype; LUSC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg22535103 chr8:58192502 C8orf71 -0.77 -7.98 -0.4 2.39e-14 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg27284194 chr4:1044797 NA -0.35 -5.71 -0.3 2.52e-8 Obesity-related traits; LUSC cis rs4356932 1.000 rs6532114 chr4:76957974 T/C cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.63e-8 Blood protein levels; LUSC cis rs17270561 0.609 rs9393665 chr6:25744284 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.73 0.39 1.29e-13 Iron status biomarkers; LUSC cis rs1044826 1.000 rs12695700 chr3:139212098 C/G cg00490450 chr3:139108681 COPB2 0.51 6.8 0.35 4.8e-11 Obesity-related traits; LUSC cis rs8092503 1.000 rs62091462 chr18:52488698 T/C cg12377874 chr18:52495404 RAB27B 0.35 6.25 0.32 1.27e-9 Childhood body mass index; LUSC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg17143192 chr8:8559678 CLDN23 0.65 9.49 0.46 4.57e-19 Obesity-related traits; LUSC cis rs4450131 0.522 rs3781451 chr10:126355477 G/A cg20435097 chr10:126320824 FAM53B 0.23 5.87 0.31 1.06e-8 White blood cell count (basophil); LUSC cis rs11711311 1.000 rs12636577 chr3:113497507 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.49 6.84 0.35 3.9e-11 IgG glycosylation; LUSC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg27539214 chr16:67997921 SLC12A4 -0.57 -7.54 -0.38 4.58e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg03676636 chr4:99064102 C4orf37 -0.35 -7.69 -0.39 1.65e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg23131131 chr22:24373011 LOC391322 -0.51 -7.43 -0.38 9.43e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4919694 1.000 rs11191490 chr10:104745174 T/A cg04362960 chr10:104952993 NT5C2 1.13 12.36 0.56 3.72e-29 Arsenic metabolism; LUSC cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg12219531 chr12:120966889 COQ5 0.62 8.31 0.41 2.42e-15 High light scatter reticulocyte count; LUSC cis rs11671005 0.735 rs12977592 chr19:58961056 C/G cg26874164 chr19:58962979 ZNF324B -0.45 -5.84 -0.3 1.23e-8 Mean platelet volume; LUSC cis rs7617773 0.779 rs9833309 chr3:48327450 C/T cg11946769 chr3:48343235 NME6 0.86 13.87 0.6 7.36e-35 Coronary artery disease; LUSC cis rs8017423 0.967 rs59980414 chr14:90687738 G/C cg04374321 chr14:90722782 PSMC1 0.72 11.28 0.53 3.3e-25 Mortality in heart failure; LUSC cis rs7089973 0.604 rs12218498 chr10:116578489 T/C cg23260525 chr10:116636907 FAM160B1 0.43 9.04 0.44 1.29e-17 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg07716408 chr11:68623521 NA -0.33 -6.44 -0.33 4.23e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg14584255 chr6:163149320 PACRG;PARK2 -0.38 -7.46 -0.38 7.71e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11864453 0.713 rs9926156 chr16:72142895 G/C cg16558253 chr16:72132732 DHX38 -0.38 -5.97 -0.31 6.17e-9 Fibrinogen levels; LUSC trans rs13011075 0.919 rs6709464 chr2:68622220 C/T cg14221825 chr19:46271408 SIX5 0.42 6.03 0.31 4.32e-9 Mean corpuscular volume; LUSC cis rs1801251 1.000 rs7606090 chr2:233606740 T/C cg25237894 chr2:233734115 C2orf82 0.34 6.36 0.33 6.67e-10 Coronary artery disease; LUSC cis rs4654899 0.865 rs6673455 chr1:21361048 T/C cg01072550 chr1:21505969 NA -0.51 -7.45 -0.38 7.9e-13 Superior frontal gyrus grey matter volume; LUSC trans rs9393777 0.778 rs66841633 chr6:27382386 G/T cg06606381 chr12:133084897 FBRSL1 -1.03 -9.54 -0.46 3.07e-19 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg15017067 chr4:17643749 FAM184B 0.33 5.66 0.3 3.3e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7828089 0.561 rs13266541 chr8:22266135 G/A cg12081754 chr8:22256438 SLC39A14 0.8 13.08 0.58 7.67e-32 Verbal declarative memory; LUSC cis rs5744897 0.655 rs35131280 chr12:133275974 A/G cg26621607 chr12:133180238 NA 0.46 5.68 0.3 2.93e-8 Urate levels in overweight individuals; LUSC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg23205692 chr1:25664452 TMEM50A -0.38 -5.69 -0.3 2.85e-8 Erythrocyte sedimentation rate; LUSC cis rs1681630 0.545 rs12790666 chr11:47983477 G/A cg18512352 chr11:47633146 NA -0.3 -6.05 -0.31 3.8e-9 Height; LUSC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg24675056 chr1:15929824 NA 0.45 7.76 0.39 1.03e-13 Systolic blood pressure; LUSC cis rs174601 0.861 rs174581 chr11:61606683 G/A cg19610905 chr11:61596333 FADS2 -0.51 -7.74 -0.39 1.21e-13 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; LUSC cis rs7215564 0.908 rs7503757 chr17:78685599 A/G cg23238734 chr17:78661607 RPTOR 0.55 6.71 0.34 8.4e-11 Myopia (pathological); LUSC cis rs500891 0.868 rs62419326 chr6:84145041 C/T cg08257003 chr6:84140564 ME1 0.35 7.27 0.37 2.56e-12 Platelet-derived growth factor BB levels; LUSC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg26769984 chr7:1090371 C7orf50 0.58 8.06 0.4 1.34e-14 Bronchopulmonary dysplasia; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg19318889 chr4:1322082 MAEA 0.48 7.69 0.39 1.68e-13 Obesity-related traits; LUSC trans rs804280 1.000 rs804281 chr8:11611865 A/G cg08975724 chr8:8085496 FLJ10661 0.52 7.23 0.37 3.28e-12 Myopia (pathological); LUSC cis rs4629180 0.586 rs1995826 chr2:102129420 A/G cg04415270 chr2:102091202 RFX8 0.42 7.19 0.37 4.34e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs208520 0.526 rs4710310 chr6:66802808 T/C cg07460842 chr6:66804631 NA -1.25 -27.41 -0.83 1.81e-87 Exhaled nitric oxide output; LUSC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg07701084 chr6:150067640 NUP43 0.55 8.35 0.42 1.9e-15 Lung cancer; LUSC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg06640241 chr16:89574553 SPG7 0.92 17.22 0.69 5.16e-48 Multiple myeloma (IgH translocation); LUSC trans rs6982636 1.000 rs17321515 chr8:126486409 C/T cg13325919 chr3:181432053 SOX2;SOX2OT 0.34 6.68 0.34 1.01e-10 Lipid metabolism phenotypes; LUSC cis rs9549260 0.755 rs59308928 chr13:41245079 C/T cg21288729 chr13:41239152 FOXO1 0.63 9.8 0.47 4.43e-20 Red blood cell count; LUSC cis rs7202877 0.706 rs4888393 chr16:75413673 C/T cg03315344 chr16:75512273 CHST6 0.43 6.42 0.33 4.69e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.36 -0.69 1.44e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.43 0.53 9.29e-26 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg03676636 chr4:99064102 C4orf37 0.32 7.05 0.36 1.06e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg06850241 chr22:41845214 NA -0.32 -6.01 -0.31 4.96e-9 Vitiligo; LUSC cis rs9297145 0.585 rs17147666 chr7:98781457 A/C cg05967295 chr7:98741636 SMURF1 -0.66 -10.33 -0.49 6.79e-22 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs68092024 0.704 rs792832 chr3:99474862 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 6.39 0.33 5.43e-10 Cleft lip with or without cleft palate; LUSC cis rs2273669 0.667 rs77936298 chr6:109350616 A/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs12760731 0.641 rs10047148 chr1:178250266 T/C cg00404053 chr1:178313656 RASAL2 0.63 6.63 0.34 1.37e-10 Obesity-related traits; LUSC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg13939156 chr17:80058883 NA 0.34 6.69 0.34 9.5e-11 Life satisfaction; LUSC cis rs9611519 0.929 rs4820425 chr22:41431342 C/A cg13813247 chr22:41461852 NA -0.36 -6.55 -0.34 2.19e-10 Neuroticism; LUSC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg13114125 chr14:105738426 BRF1 -0.91 -15.96 -0.66 5.33e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11644478 chr21:40555479 PSMG1 0.94 18.94 0.72 7.18e-55 Cognitive function; LUSC cis rs7202877 0.561 rs4888369 chr16:75307277 T/C cg04384234 chr16:75411784 CFDP1 -0.66 -8.92 -0.44 3.07e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg09034736 chr1:150693464 HORMAD1 0.47 6.8 0.35 4.71e-11 Melanoma; LUSC cis rs1670533 1.000 rs13135215 chr4:1054364 A/G cg27284194 chr4:1044797 NA 0.59 8.86 0.44 4.9e-17 Recombination rate (females); LUSC trans rs9747201 0.962 rs62078313 chr17:80116708 A/C cg07393940 chr7:158741817 NA -0.53 -8.42 -0.42 1.09e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs35110281 0.517 rs11089020 chr21:44939991 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 9.98 0.48 1.09e-20 Mean corpuscular volume; LUSC cis rs9420 0.890 rs547891 chr11:57499065 C/T cg02958346 chr11:57425731 CLP1 0.42 6.12 0.32 2.64e-9 Schizophrenia; LUSC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg03264133 chr6:25882463 NA -0.44 -7.5 -0.38 6e-13 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg26727032 chr16:67993705 SLC12A4 -0.45 -5.94 -0.31 7.32e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18872604 chr11:64002754 VEGFB 0.41 6.21 0.32 1.58e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9653442 0.609 rs2576678 chr2:100704810 T/C cg07810366 chr2:100720526 AFF3 -0.45 -7.61 -0.38 2.86e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg02038168 chr22:39784481 NA -0.51 -8.08 -0.4 1.22e-14 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13921387 chr1:109655348 C1orf194;KIAA1324 0.46 6.36 0.33 6.61e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13315871 0.929 rs13101057 chr3:58291467 A/G cg20936604 chr3:58311152 NA -0.71 -6.33 -0.33 7.74e-10 Cholesterol, total; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27053636 chr16:58163123 C16orf80 0.43 6.09 0.32 3.12e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs62103177 0.525 rs612913 chr18:77845882 A/G cg14227996 chr4:17616232 MED28 -0.54 -6.06 -0.31 3.69e-9 Opioid sensitivity; LUSC cis rs804280 0.662 rs11784764 chr8:11610874 C/T cg00262122 chr8:11665843 FDFT1 -0.51 -6.5 -0.34 2.89e-10 Myopia (pathological); LUSC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg00033643 chr7:134001901 SLC35B4 0.47 7.42 0.38 9.63e-13 Mean platelet volume; LUSC cis rs8060686 0.641 rs113502835 chr16:68238965 A/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.39 -0.33 5.59e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg14668632 chr7:2872130 GNA12 -0.43 -6.81 -0.35 4.42e-11 Height; LUSC cis rs7917772 0.560 rs35095897 chr10:104377759 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.67 -10.98 -0.51 3.86e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs478304 0.654 rs6591187 chr11:65460086 C/G cg05805236 chr11:65401703 PCNXL3 -0.65 -10.61 -0.5 7.57e-23 Acne (severe); LUSC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -7.39 -0.37 1.18e-12 Electroencephalogram traits; LUSC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs7223966 1.000 rs11654335 chr17:61797579 A/T cg00945038 chr17:61921165 SMARCD2 0.4 6.09 0.32 3.17e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9807989 0.765 rs9807962 chr2:102971664 A/G cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg03146154 chr1:46216737 IPP 0.56 8.34 0.42 2.02e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg11062466 chr8:58055876 NA 0.49 6.3 0.33 9.37e-10 Developmental language disorder (linguistic errors); LUSC cis rs7937682 0.883 rs1613778 chr11:111456105 G/C cg19812747 chr11:111475976 SIK2 -0.55 -8.08 -0.4 1.16e-14 Primary sclerosing cholangitis; LUSC cis rs4268898 0.636 rs72787383 chr2:24583861 G/A cg06627628 chr2:24431161 ITSN2 -0.87 -12.7 -0.57 2.07e-30 Asthma; LUSC cis rs981844 0.712 rs1012029 chr4:154749233 C/T cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg05776053 chr2:74358815 NA 0.45 7.26 0.37 2.76e-12 Gestational age at birth (maternal effect); LUSC cis rs12617721 0.756 rs3754889 chr2:99088633 T/G cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg09640425 chr7:158790006 NA -0.51 -8.1 -0.41 1.05e-14 Facial morphology (factor 20); LUSC cis rs950169 0.580 rs11633762 chr15:85187152 T/C cg17173187 chr15:85201210 NMB 0.47 8.97 0.44 2.21e-17 Schizophrenia; LUSC cis rs73206853 0.841 rs74503171 chr12:111061652 A/G cg12870014 chr12:110450643 ANKRD13A 0.69 7.17 0.37 4.73e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs61869271 0.871 rs6585310 chr10:116732726 G/A cg23260525 chr10:116636907 FAM160B1 0.31 5.99 0.31 5.47e-9 Tonsillectomy; LUSC cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.52 7.27 0.37 2.56e-12 Gut microbiome composition (summer); LUSC cis rs9300255 0.639 rs941306 chr12:123715113 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.22 -0.32 1.48e-9 Neutrophil percentage of white cells; LUSC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg23758822 chr17:41437982 NA 1.02 19.7 0.73 7.26e-58 Menopause (age at onset); LUSC cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg05283184 chr6:79620031 NA -0.58 -12.26 -0.56 9.1e-29 Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg23791538 chr6:167370224 RNASET2 -0.41 -6.49 -0.33 3.17e-10 Crohn's disease; LUSC cis rs7267979 0.932 rs433352 chr20:25467992 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.42 -0.69 8.72e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8027181 0.839 rs11072385 chr15:73020839 A/G cg25632853 chr15:73088954 NA 0.32 6.63 0.34 1.36e-10 Triglyceride levels; LUSC trans rs4650994 0.544 rs10798613 chr1:178500022 C/T cg05059571 chr16:84539110 KIAA1609 -0.48 -9.16 -0.45 5.48e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -8.64 -0.43 2.43e-16 Personality dimensions; LUSC trans rs7615952 0.576 rs2276727 chr3:125826243 C/T cg07211511 chr3:129823064 LOC729375 -0.78 -10.06 -0.48 5.66e-21 Blood pressure (smoking interaction); LUSC trans rs877282 0.945 rs34367686 chr10:791868 G/C cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs34779708 0.931 rs4934524 chr10:35270921 G/C cg03585969 chr10:35415529 CREM 0.66 9.47 0.46 5.19e-19 Inflammatory bowel disease;Crohn's disease; LUSC trans rs62103177 0.810 rs62103197 chr18:77632923 G/A cg14227996 chr4:17616232 MED28 0.85 7.96 0.4 2.66e-14 Opioid sensitivity; LUSC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg26408565 chr15:76604113 ETFA -0.47 -7.44 -0.38 8.35e-13 Blood metabolite levels; LUSC cis rs9747201 0.862 rs11651738 chr17:80178691 A/T cg18209359 chr17:80159595 CCDC57 -0.36 -5.82 -0.3 1.39e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1595825 0.945 rs6736825 chr2:198854224 C/T cg00982548 chr2:198649783 BOLL -0.56 -7.01 -0.36 1.33e-11 Ulcerative colitis; LUSC cis rs3768617 0.528 rs10911240 chr1:183062948 T/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.75 0.51 2.35e-23 Fuchs's corneal dystrophy; LUSC trans rs62238980 0.614 rs74399071 chr22:32455990 G/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg14004847 chr7:1930337 MAD1L1 -0.5 -7.58 -0.38 3.54e-13 Bipolar disorder and schizophrenia; LUSC cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg24642439 chr20:33292090 TP53INP2 0.51 7.75 0.39 1.14e-13 Coronary artery disease; LUSC cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg10172584 chr19:19639581 YJEFN3 0.48 5.69 0.3 2.73e-8 Bipolar disorder; LUSC trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg20587970 chr11:113659929 NA -1.35 -19.01 -0.72 3.8e-55 Hip circumference adjusted for BMI; LUSC cis rs1595825 0.945 rs1850634 chr2:198827896 T/C cg00982548 chr2:198649783 BOLL -0.58 -7.29 -0.37 2.32e-12 Ulcerative colitis; LUSC cis rs2120019 1.000 rs2120019 chr15:75334184 T/C cg09165964 chr15:75287851 SCAMP5 -1.15 -18.88 -0.72 1.33e-54 Blood trace element (Zn levels); LUSC cis rs829883 0.664 rs865509 chr12:98854444 T/A cg25150519 chr12:98850993 NA 0.83 14.13 0.61 7.1e-36 Colorectal adenoma (advanced); LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg13560548 chr3:10150139 C3orf24 0.52 7.18 0.37 4.45e-12 Alzheimer's disease; LUSC cis rs9653442 0.545 rs12987209 chr2:100761148 C/T cg07810366 chr2:100720526 AFF3 -0.45 -7.75 -0.39 1.13e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs10488512 chr7:91753579 C/T cg17063962 chr7:91808500 NA 0.59 9.24 0.45 2.93e-18 Breast cancer; LUSC cis rs6500395 0.962 rs9924483 chr16:48646258 C/T cg04672837 chr16:48644449 N4BP1 0.47 6.66 0.34 1.16e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs5753618 0.509 rs2413033 chr22:31574213 A/G cg22777020 chr22:31556080 RNF185 -0.46 -5.8 -0.3 1.54e-8 Colorectal cancer; LUSC cis rs231513 0.681 rs8079623 chr17:42027330 C/G cg26893861 chr17:41843967 DUSP3 -0.54 -5.68 -0.3 2.93e-8 Cognitive function; LUSC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg05283184 chr6:79620031 NA -0.57 -12.0 -0.55 8.16e-28 Intelligence (multi-trait analysis); LUSC cis rs7647973 0.626 rs6809879 chr3:49834571 A/G cg03060546 chr3:49711283 APEH -0.63 -7.46 -0.38 7.34e-13 Menarche (age at onset); LUSC cis rs7100689 0.646 rs1815650 chr10:82157464 C/T cg01528321 chr10:82214614 TSPAN14 0.84 12.92 0.58 2.91e-31 Post bronchodilator FEV1; LUSC cis rs17685 0.784 rs1613890 chr7:75735037 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.69 -0.39 1.68e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs6488211 chr12:34375620 A/T cg13010199 chr12:38710504 ALG10B -0.63 -9.78 -0.47 5e-20 Morning vs. evening chronotype; LUSC cis rs6700896 0.500 rs12043772 chr1:66135034 T/A cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs57221529 0.766 rs12519469 chr5:581772 A/G cg17948913 chr5:572064 NA 0.37 5.73 0.3 2.21e-8 Lung disease severity in cystic fibrosis; LUSC cis rs9420 0.961 rs80304923 chr11:57522823 C/G cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.22e-10 Schizophrenia; LUSC cis rs66887589 0.967 rs59516282 chr4:120502016 G/A cg09307838 chr4:120376055 NA -0.48 -7.33 -0.37 1.77e-12 Diastolic blood pressure; LUSC trans rs9329221 0.537 rs6601414 chr8:9976748 G/A cg06636001 chr8:8085503 FLJ10661 0.47 6.95 0.36 1.93e-11 Neuroticism; LUSC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg08683831 chr4:1404607 NA 0.35 5.94 0.31 7.14e-9 Obesity-related traits; LUSC cis rs2414059 0.518 rs8026653 chr15:50736620 G/C cg08437265 chr15:50716283 USP8 -0.41 -6.0 -0.31 5.14e-9 QT interval; LUSC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg05234568 chr11:5960015 NA -0.6 -8.67 -0.43 1.97e-16 DNA methylation (variation); LUSC cis rs977987 0.778 rs11149825 chr16:75434878 C/T cg03315344 chr16:75512273 CHST6 0.48 9.03 0.44 1.41e-17 Dupuytren's disease; LUSC cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg16586182 chr3:47516702 SCAP 0.52 7.41 0.38 1.03e-12 Birth weight; LUSC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg21984481 chr17:79567631 NPLOC4 0.75 15.75 0.65 3.55e-42 Eye color traits; LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg27170947 chr2:26402098 FAM59B -0.71 -10.67 -0.5 4.58e-23 Gut microbiome composition (summer); LUSC cis rs9486719 0.843 rs2103539 chr6:96844342 T/A cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC cis rs7824557 0.614 rs2736277 chr8:11218893 C/T cg21293242 chr8:11204541 TDH -0.35 -6.78 -0.35 5.61e-11 Retinal vascular caliber; LUSC cis rs9463078 0.527 rs2040032 chr6:44743009 C/T cg25276700 chr6:44698697 NA 0.3 6.33 0.33 7.67e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg09904177 chr6:26538194 HMGN4 -0.74 -6.53 -0.34 2.5e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg12863693 chr15:85201151 NMB -0.27 -6.16 -0.32 2.06e-9 P wave terminal force; LUSC cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg22307029 chr19:49891270 CCDC155 -0.62 -7.91 -0.4 3.84e-14 Multiple sclerosis; LUSC cis rs4423214 0.650 rs7940244 chr11:71221574 C/T cg05163923 chr11:71159392 DHCR7 -0.64 -8.19 -0.41 5.45e-15 Vitamin D levels; LUSC cis rs2953174 0.938 rs2953167 chr2:241539366 T/C cg07929629 chr2:241523174 NA 0.47 6.11 0.32 2.82e-9 Bipolar disorder; LUSC cis rs4654899 0.965 rs6692081 chr1:21296363 T/C cg01072550 chr1:21505969 NA -0.55 -8.41 -0.42 1.23e-15 Superior frontal gyrus grey matter volume; LUSC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg17718321 chr1:152188247 HRNR -0.38 -6.81 -0.35 4.58e-11 Inflammatory skin disease; LUSC cis rs11608355 0.545 rs4766603 chr12:109892106 T/C cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs9902453 0.967 rs4533341 chr17:28495672 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.52 7.84 0.39 6.24e-14 Coffee consumption (cups per day); LUSC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.79 0.35 5.19e-11 Age-related macular degeneration (geographic atrophy); LUSC trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -7.68 -0.39 1.83e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs981844 0.775 rs17299519 chr4:154762123 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.67 0.34 1.09e-10 Response to statins (LDL cholesterol change); LUSC cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg26597838 chr10:835615 NA -0.48 -6.43 -0.33 4.3e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg02807482 chr3:125708958 NA -0.49 -6.08 -0.32 3.22e-9 Blood pressure (smoking interaction); LUSC cis rs2463822 1.000 rs12279819 chr11:62137245 G/A cg06239285 chr11:62104954 ASRGL1 -0.93 -10.31 -0.49 7.79e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7903847 0.596 rs9787426 chr10:99155327 A/G cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs4969178 0.965 rs12450528 chr17:76395753 G/A cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11644478 chr21:40555479 PSMG1 0.9 17.03 0.68 2.9e-47 Cognitive function; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14450231 chr5:172199425 DUSP1 0.44 6.53 0.34 2.44e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9494145 0.667 rs1331309 chr6:135406178 T/G cg24558204 chr6:135376177 HBS1L 0.48 5.93 0.31 7.51e-9 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs829880 0.558 rs249820 chr12:98897473 A/G cg25150519 chr12:98850993 NA 0.44 5.65 0.3 3.52e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg15445000 chr17:37608096 MED1 0.4 6.8 0.35 4.85e-11 Glomerular filtration rate (creatinine); LUSC cis rs9818941 0.793 rs9874758 chr3:157735625 A/G cg08654915 chr3:157813417 NA -0.33 -7.6 -0.38 3.03e-13 Height; LUSC cis rs3849570 0.643 rs1851928 chr3:81975395 C/T cg07356753 chr3:81810745 GBE1 -0.49 -7.28 -0.37 2.44e-12 Waist circumference;Body mass index; LUSC cis rs1215050 0.740 rs1084784 chr4:98961711 T/G cg03676636 chr4:99064102 C4orf37 -0.26 -5.65 -0.3 3.41e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg20203395 chr5:56204925 C5orf35 -0.79 -10.38 -0.49 4.48e-22 Initial pursuit acceleration; LUSC cis rs30380 0.632 rs30186 chr5:96124447 G/C cg16492584 chr5:96139282 ERAP1 -0.52 -7.05 -0.36 1e-11 Cerebrospinal fluid biomarker levels; LUSC cis rs77741769 0.571 rs4766979 chr12:121281748 G/A cg02419362 chr12:121203948 SPPL3 0.46 8.51 0.42 5.89e-16 Mean corpuscular volume; LUSC cis rs950169 0.519 rs7237 chr15:85186577 C/T cg11189052 chr15:85197271 WDR73 0.53 6.74 0.35 6.78e-11 Schizophrenia; LUSC cis rs981844 1.000 rs2606325 chr4:154652681 C/T cg14289246 chr4:154710475 SFRP2 0.54 6.77 0.35 5.92e-11 Response to statins (LDL cholesterol change); LUSC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg06074448 chr4:187884817 NA -0.46 -7.66 -0.39 2.08e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10170310 0.872 rs62161711 chr2:139259222 A/G cg10095539 chr2:139258744 SPOPL 0.33 5.92 0.31 8.04e-9 Response to antipsychotic treatment; LUSC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.76 -9.64 -0.47 1.42e-19 Schizophrenia; LUSC cis rs1670533 1.000 rs2100411 chr4:1074412 T/C cg27284194 chr4:1044797 NA 0.58 8.7 0.43 1.57e-16 Recombination rate (females); LUSC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg24829409 chr8:58192753 C8orf71 -0.54 -5.92 -0.31 8.21e-9 Developmental language disorder (linguistic errors); LUSC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg12257692 chr3:49977190 RBM6 -0.26 -7.17 -0.37 4.7e-12 Intelligence (multi-trait analysis); LUSC cis rs9650657 0.513 rs7005884 chr8:10796472 A/G cg21775007 chr8:11205619 TDH -0.5 -7.19 -0.37 4.41e-12 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11236850 chr4:8443022 ACOX3 0.46 6.78 0.35 5.44e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg00750074 chr16:89608354 SPG7 -0.45 -7.83 -0.39 6.45e-14 Multiple myeloma (IgH translocation); LUSC cis rs7122539 0.768 rs7931485 chr11:66578635 G/A cg24851651 chr11:66362959 CCS 0.46 7.53 0.38 4.9e-13 HIV-1 susceptibility; LUSC cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.55 -8.07 -0.4 1.29e-14 Colorectal cancer; LUSC trans rs208520 0.874 rs208485 chr6:66925654 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -14.1 -0.61 9.35e-36 Exhaled nitric oxide output; LUSC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs9905704 0.846 rs304262 chr17:56814456 A/G cg12560992 chr17:57184187 TRIM37 0.58 8.21 0.41 5.05e-15 Testicular germ cell tumor; LUSC trans rs11098499 0.775 rs10029303 chr4:120286755 T/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg13902645 chr11:5959945 NA -0.55 -8.45 -0.42 9.18e-16 DNA methylation (variation); LUSC cis rs793571 0.502 rs395601 chr15:59063196 G/C cg05156742 chr15:59063176 FAM63B 0.57 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs2721195 1.000 rs1871541 chr8:145681713 G/T cg11211951 chr8:145729740 GPT -0.57 -11.22 -0.52 5.23e-25 Age at first birth; LUSC cis rs11190604 0.725 rs9420796 chr10:102323092 G/C cg16342193 chr10:102329863 NA -0.37 -6.45 -0.33 3.86e-10 Palmitoleic acid (16:1n-7) levels; LUSC trans rs877282 0.898 rs11253353 chr10:766862 C/A cg22713356 chr15:30763199 NA 1.15 14.94 0.63 5.3e-39 Uric acid levels; LUSC cis rs9527 0.590 rs12355120 chr10:104852166 T/G cg04362960 chr10:104952993 NT5C2 0.61 9.64 0.47 1.4e-19 Arsenic metabolism; LUSC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg27124370 chr19:33622961 WDR88 0.58 8.07 0.4 1.24e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs9653442 0.564 rs11902705 chr2:100795207 A/G cg22139774 chr2:100720529 AFF3 0.38 6.61 0.34 1.55e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg04518342 chr5:131593106 PDLIM4 0.51 8.96 0.44 2.31e-17 Acylcarnitine levels; LUSC cis rs6138458 0.847 rs56312312 chr20:24959386 C/A cg06937882 chr20:24974362 C20orf3 -0.46 -7.78 -0.39 9.13e-14 Blood protein levels; LUSC cis rs806215 0.951 rs327516 chr7:127255795 C/G cg25922125 chr7:127225783 GCC1 0.53 6.58 0.34 1.87e-10 Type 2 diabetes; LUSC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg21918786 chr6:109611834 NA -0.36 -6.01 -0.31 4.73e-9 Reticulocyte fraction of red cells; LUSC cis rs7119038 0.865 rs7951740 chr11:118740418 G/C cg19308663 chr11:118741387 NA -0.35 -5.99 -0.31 5.49e-9 Sjögren's syndrome; LUSC trans rs7824557 0.628 rs11782706 chr8:11186215 A/C cg15556689 chr8:8085844 FLJ10661 0.45 6.69 0.34 9.39e-11 Retinal vascular caliber; LUSC cis rs958025 1 rs958025 chr15:78759348 C/T cg18825076 chr15:78729989 IREB2 0.47 6.49 0.33 3.14e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC trans rs12682352 0.602 rs4841044 chr8:8664940 A/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.1 -0.32 2.97e-9 Neuroticism; LUSC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.17 0.45 4.94e-18 Monocyte percentage of white cells; LUSC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.74 0.43 1.16e-16 Prudent dietary pattern; LUSC cis rs477692 0.870 rs475250 chr10:131412558 C/G cg11019008 chr10:131425282 MGMT 0.42 6.4 0.33 5.3e-10 Response to temozolomide; LUSC cis rs7681440 0.583 rs2619339 chr4:90777468 G/C cg06632027 chr4:90757378 SNCA -0.37 -5.75 -0.3 1.99e-8 Dementia with Lewy bodies; LUSC cis rs826838 0.510 rs10876149 chr12:39228083 C/G cg26384229 chr12:38710491 ALG10B -0.74 -11.28 -0.53 3.34e-25 Heart rate; LUSC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg12560992 chr17:57184187 TRIM37 -0.79 -14.97 -0.63 4.14e-39 Intelligence (multi-trait analysis); LUSC cis rs7587476 0.601 rs1129804 chr2:215674323 C/G cg04004882 chr2:215674386 BARD1 -0.52 -7.27 -0.37 2.54e-12 Neuroblastoma; LUSC cis rs9611519 0.929 rs9611469 chr22:41433319 T/C cg13813247 chr22:41461852 NA -0.36 -6.59 -0.34 1.72e-10 Neuroticism; LUSC cis rs6940638 0.688 rs9393791 chr6:27132529 C/G cg05738196 chr6:26577821 NA -0.48 -6.8 -0.35 4.9e-11 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg26380479 chr7:97908229 NA -0.28 -6.13 -0.32 2.54e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7639513 0.767 rs7617041 chr3:12709167 A/G cg23032965 chr3:12705835 RAF1 0.76 11.48 0.53 6.24e-26 Itch intensity from mosquito bite; LUSC cis rs11971779 0.680 rs10271297 chr7:139052310 A/T cg07862535 chr7:139043722 LUC7L2 0.56 7.04 0.36 1.12e-11 Diisocyanate-induced asthma; LUSC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11644478 chr21:40555479 PSMG1 -0.74 -13.22 -0.59 2.21e-32 Cognitive function; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03745386 chr12:29534188 ERGIC2 0.36 6.02 0.31 4.48e-9 Triglycerides; LUSC cis rs2204008 0.614 rs4578492 chr12:38036350 T/C cg13010199 chr12:38710504 ALG10B 0.71 10.9 0.51 7.24e-24 Bladder cancer; LUSC cis rs2219968 1.000 rs13262830 chr8:78957669 C/T cg00738934 chr8:78996279 NA 0.37 6.89 0.35 2.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg16606324 chr3:10149918 C3orf24 0.62 9.08 0.44 9.81e-18 Alzheimer's disease; LUSC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.67 9.51 0.46 3.94e-19 Age-related macular degeneration (geographic atrophy); LUSC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg16339924 chr4:17578868 LAP3 0.55 8.25 0.41 3.69e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7582720 1.000 rs6435169 chr2:203753016 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg13852791 chr20:30311386 BCL2L1 0.83 10.85 0.51 1.11e-23 Mean corpuscular hemoglobin; LUSC cis rs7584330 0.554 rs729389 chr2:238425118 G/A cg16989719 chr2:238392110 NA -0.43 -6.13 -0.32 2.41e-9 Prostate cancer; LUSC cis rs243505 0.737 rs243538 chr7:148404379 G/A cg09806900 chr7:148480153 CUL1 -0.52 -6.67 -0.34 1.06e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs2262909 0.925 rs73019900 chr19:22286680 G/A cg05197062 chr11:11642011 GALNTL4 0.54 7.5 0.38 5.64e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg11764359 chr7:65958608 NA -0.69 -10.77 -0.51 2.04e-23 Aortic root size; LUSC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.57 -6.95 -0.36 1.91e-11 Birth weight; LUSC cis rs25645 0.823 rs12453334 chr17:38153473 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.69 11.82 0.54 3.47e-27 Myeloid white cell count; LUSC cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 11.95 0.55 1.25e-27 Personality dimensions; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13914598 chr12:123460194 OGFOD2;ABCB9 0.44 6.79 0.35 5.01e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4253772 0.575 rs74879643 chr22:46660014 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 5.95 0.31 6.7e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg08807101 chr21:30365312 RNF160 0.8 15.13 0.64 9.03e-40 Dental caries; LUSC cis rs10911363 0.592 rs2702205 chr1:183457198 A/G cg09173681 chr1:183549694 NCF2 0.66 12.24 0.56 1.08e-28 Systemic lupus erythematosus; LUSC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg17143192 chr8:8559678 CLDN23 0.63 9.27 0.45 2.34e-18 Obesity-related traits; LUSC trans rs1486139 1.000 rs990525 chr7:46296689 C/T cg17534202 chr9:96721102 NA 0.34 6.14 0.32 2.36e-9 Select biomarker traits; LUSC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.37 -0.37 1.34e-12 Electroencephalogram traits; LUSC cis rs950027 0.620 rs35861938 chr15:45637343 T/C cg21132104 chr15:45694354 SPATA5L1 0.41 6.04 0.31 4.09e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.06 0.66 2.06e-43 Platelet count; LUSC cis rs9611565 0.625 rs12483991 chr22:41935285 A/G cg03806693 chr22:41940476 POLR3H -0.85 -12.2 -0.56 1.5e-28 Vitiligo; LUSC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg06212747 chr3:49208901 KLHDC8B 0.44 6.02 0.31 4.7e-9 Parkinson's disease; LUSC cis rs2573652 0.722 rs12908133 chr15:100544405 G/A cg09918751 chr15:100517450 ADAMTS17 -0.3 -5.66 -0.3 3.26e-8 Height; LUSC cis rs9682041 0.627 rs11924474 chr3:170091333 T/G cg11886554 chr3:170076028 SKIL 0.69 9.41 0.46 8.26e-19 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg22963979 chr7:1858916 MAD1L1 -0.63 -10.07 -0.48 5.44e-21 Bipolar disorder and schizophrenia; LUSC cis rs7824557 0.564 rs1435275 chr8:11235735 T/C cg27411982 chr8:10470053 RP1L1 -0.38 -6.01 -0.31 4.97e-9 Retinal vascular caliber; LUSC cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -10.92 -0.51 6.2e-24 Chronic sinus infection; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14963534 chr19:17420130 DDA1 0.66 6.02 0.31 4.66e-9 Cognitive performance; LUSC cis rs2227564 0.700 rs2675677 chr10:75648249 C/A cg23231163 chr10:75533350 FUT11 -0.42 -5.94 -0.31 7.35e-9 Crohn's disease;Inflammatory bowel disease; LUSC trans rs2490361 1.000 rs10925334 chr1:237326051 A/T cg15653282 chr18:11689218 GNAL 0.39 6.02 0.31 4.6e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs644799 0.542 rs10831417 chr11:95467262 A/G cg25622487 chr11:95524042 FAM76B;CEP57 -0.52 -7.19 -0.37 4.27e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg26338869 chr17:61819248 STRADA 0.42 6.01 0.31 4.85e-9 Prudent dietary pattern; LUSC cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.19 -0.45 4.31e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7267979 0.903 rs6115101 chr20:25229564 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.21 0.66 5.1e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg20276088 chr3:133502917 NA -0.38 -5.68 -0.3 2.98e-8 Iron status biomarkers; LUSC cis rs8032315 0.965 rs4932373 chr15:91429287 A/C cg05469396 chr15:91419421 FURIN -0.42 -6.53 -0.34 2.52e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg03433033 chr1:76189801 ACADM -0.83 -14.7 -0.63 4.53e-38 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg05890377 chr2:74357713 NA 0.74 14.56 0.62 1.6e-37 Gestational age at birth (maternal effect); LUSC cis rs16854884 1.000 rs58251824 chr3:143786258 T/C cg06585982 chr3:143692056 C3orf58 0.47 6.56 0.34 2e-10 Economic and political preferences (feminism/equality); LUSC cis rs1023500 0.505 rs134878 chr22:42663874 A/G cg15557168 chr22:42548783 NA -0.42 -6.57 -0.34 1.94e-10 Schizophrenia; LUSC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs6835098 0.816 rs13111572 chr4:174159788 G/A cg08422745 chr4:174089978 GALNT7 0.81 12.93 0.58 2.74e-31 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs12618769 0.652 rs7585747 chr2:99219071 T/C cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 7.12 0.36 6.77e-12 Hip circumference adjusted for BMI; LUSC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg07507251 chr3:52567010 NT5DC2 0.34 6.72 0.35 7.67e-11 Bipolar disorder; LUSC cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.48 -7.57 -0.38 3.69e-13 Educational attainment; LUSC cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg01579765 chr21:45077557 HSF2BP -0.47 -9.7 -0.47 8.9e-20 Mean corpuscular volume; LUSC cis rs1559088 1.000 rs7245404 chr19:33550589 C/T cg17764715 chr19:33622953 WDR88 0.58 7.88 0.4 4.53e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg23711669 chr6:146136114 FBXO30 0.9 17.08 0.68 1.94e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg22098556 chr9:138798463 CAMSAP1 -0.43 -6.64 -0.34 1.3e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7511006 0.893 rs2038049 chr22:50654888 G/C cg08875078 chr22:50639485 SELO 0.45 6.28 0.32 1.07e-9 Obesity-related traits; LUSC cis rs66731853 0.771 rs541244 chr1:20889380 G/A cg04087271 chr1:20915334 CDA -0.51 -8.89 -0.44 3.89e-17 Mean corpuscular volume; LUSC cis rs9527 0.590 rs7917650 chr10:104937100 G/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.26e-10 Arsenic metabolism; LUSC trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg03929089 chr4:120376271 NA -0.45 -6.26 -0.32 1.18e-9 Height; LUSC cis rs4499344 0.524 rs259242 chr19:33144248 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.91 13.4 0.59 4.59e-33 Mean platelet volume; LUSC trans rs7178375 1.000 rs1474381 chr15:31214991 T/C cg04373760 chr16:53404718 NA 0.64 8.88 0.44 4.28e-17 Hypertriglyceridemia; LUSC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg08219700 chr8:58056026 NA 0.65 7.55 0.38 4.23e-13 Developmental language disorder (linguistic errors); LUSC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.75 -7.51 -0.38 5.59e-13 Diabetic retinopathy; LUSC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg24154853 chr7:158122151 PTPRN2 -0.42 -8.26 -0.41 3.33e-15 Calcium levels; LUSC cis rs2637266 0.935 rs12414653 chr10:78394071 C/G cg18941641 chr10:78392320 NA 0.42 7.59 0.38 3.29e-13 Pulmonary function; LUSC cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.49 -0.42 6.8e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6964587 1.000 rs13239875 chr7:91716104 G/A cg17063962 chr7:91808500 NA 0.58 9.15 0.45 5.95e-18 Breast cancer; LUSC cis rs1997103 1.000 rs2177805 chr7:55404381 T/A cg17469321 chr7:55412551 NA 0.66 10.62 0.5 6.87e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg08219700 chr8:58056026 NA 0.51 6.35 0.33 7.03e-10 Developmental language disorder (linguistic errors); LUSC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.77 0.3 1.8e-8 Intelligence (multi-trait analysis); LUSC cis rs9430161 0.564 rs12081176 chr1:11034145 T/C cg02454025 chr1:11042201 C1orf127 1.03 18.59 0.71 1.77e-53 Ewing sarcoma; LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg03388025 chr16:89894329 SPIRE2 -0.32 -6.7 -0.34 8.66e-11 Vitiligo; LUSC cis rs17253792 0.822 rs28478195 chr14:56047851 G/A cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg09021430 chr5:549028 NA -0.57 -8.38 -0.42 1.51e-15 Obesity-related traits; LUSC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg23262073 chr20:60523788 NA -0.43 -6.2 -0.32 1.69e-9 Body mass index; LUSC trans rs2935183 1 rs2935183 chr17:45607572 T/G cg03886242 chr7:26192032 NFE2L3 0.37 6.01 0.31 4.8e-9 Multiple sclerosis or amyotrophic lateral sclerosis; LUSC cis rs4423214 0.840 rs1629220 chr11:71174553 C/T cg05163923 chr11:71159392 DHCR7 -0.76 -9.95 -0.48 1.32e-20 Vitamin D levels; LUSC cis rs8099014 0.954 rs4294895 chr18:56126867 T/C cg12907477 chr18:56117327 MIR122 0.43 6.69 0.34 9.48e-11 Platelet count; LUSC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg11632617 chr15:75315747 PPCDC -0.5 -6.58 -0.34 1.86e-10 Blood trace element (Zn levels); LUSC cis rs939658 0.805 rs2177056 chr15:79441489 T/C cg17916960 chr15:79447300 NA -0.53 -10.55 -0.5 1.24e-22 Refractive error; LUSC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.18 -0.37 4.55e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7246967 0.673 rs35061555 chr19:22963766 T/C cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs6952809 0.516 rs6952959 chr7:2440722 C/T cg23289794 chr7:2394357 EIF3B -0.76 -9.99 -0.48 9.5e-21 Multiple sclerosis; LUSC cis rs611744 0.647 rs4735053 chr8:109260776 A/G cg21045802 chr8:109455806 TTC35 0.43 6.62 0.34 1.41e-10 Dupuytren's disease; LUSC cis rs7833986 0.501 rs2719227 chr8:57043794 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.7 -11.46 -0.53 7.05e-26 Height; LUSC cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg03146154 chr1:46216737 IPP 0.53 7.75 0.39 1.09e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs939574 0.929 rs10190834 chr2:220070301 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.95 -8.17 -0.41 6.53e-15 Platelet distribution width; LUSC cis rs17685 0.712 rs4552844 chr7:75718095 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.69 -0.39 1.68e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4975709 0.801 rs3797063 chr5:1881549 A/T cg20790798 chr5:1857306 NA -0.38 -5.71 -0.3 2.46e-8 Cardiovascular disease risk factors; LUSC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg19592336 chr6:28129416 ZNF389 -0.44 -5.97 -0.31 6.02e-9 Depression; LUSC cis rs1358748 0.522 rs7531589 chr1:67555366 A/G cg02640540 chr1:67518911 SLC35D1 0.67 6.57 0.34 1.98e-10 Tuberculosis; LUSC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg25072359 chr17:41440525 NA 0.6 8.66 0.43 2.05e-16 Menopause (age at onset); LUSC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg24531977 chr5:56204891 C5orf35 -1.02 -15.49 -0.65 3.7e-41 Initial pursuit acceleration; LUSC cis rs2797685 0.853 rs707462 chr1:7849880 A/G cg04725166 chr1:7887271 PER3 -0.42 -5.79 -0.3 1.66e-8 Crohn's disease; LUSC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg05729581 chr11:3078854 CARS -0.38 -5.78 -0.3 1.71e-8 Longevity; LUSC cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg07148914 chr20:33460835 GGT7 0.54 8.4 0.42 1.33e-15 Height; LUSC cis rs477692 0.875 rs7091540 chr10:131420276 C/T cg11019008 chr10:131425282 MGMT -0.4 -6.2 -0.32 1.68e-9 Response to temozolomide; LUSC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg18252515 chr7:66147081 NA 1.23 14.23 0.61 2.91e-36 Diabetic kidney disease; LUSC cis rs2011503 0.882 rs4808933 chr19:19363812 T/A cg11244672 chr19:19639970 YJEFN3 -0.54 -6.59 -0.34 1.76e-10 Bipolar disorder; LUSC cis rs11098499 0.865 rs3956464 chr4:120256764 T/C cg24375607 chr4:120327624 NA 0.77 12.51 0.56 1.08e-29 Corneal astigmatism; LUSC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg26818010 chr10:134567672 INPP5A -0.88 -11.35 -0.53 1.85e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg22834771 chr12:69754056 YEATS4 -0.44 -5.75 -0.3 1.97e-8 Response to diuretic therapy; LUSC cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg15541040 chr2:3486749 NA 0.5 7.76 0.39 1.04e-13 Neurofibrillary tangles; LUSC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.56e-11 Total body bone mineral density; LUSC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.95 -0.31 6.85e-9 Vitiligo; LUSC cis rs7258465 1.000 rs271624 chr19:18627953 A/G cg06462663 chr19:18546047 ISYNA1 0.45 7.32 0.37 1.88e-12 Breast cancer; LUSC cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg05347473 chr6:146136440 FBXO30 -0.6 -10.6 -0.5 7.93e-23 Lobe attachment (rater-scored or self-reported); LUSC trans rs2840044 0.554 rs225267 chr17:33964228 T/C cg19694781 chr19:47549865 TMEM160 -1.13 -18.15 -0.7 1.04e-51 Response to radiotherapy in cancer (late toxicity); LUSC cis rs17155006 0.655 rs94604 chr7:107733856 C/T cg05962710 chr7:107745446 LAMB4 -0.32 -5.69 -0.3 2.82e-8 Pneumococcal bacteremia; LUSC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg12963246 chr6:28129442 ZNF389 -0.44 -6.12 -0.32 2.55e-9 Depression; LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg04267008 chr7:1944627 MAD1L1 -0.56 -8.48 -0.42 7.37e-16 Bipolar disorder and schizophrenia; LUSC cis rs4654899 0.758 rs6688147 chr1:21335894 A/G cg01072550 chr1:21505969 NA -0.53 -8.16 -0.41 7.06e-15 Superior frontal gyrus grey matter volume; LUSC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs3540 0.553 rs4031431 chr15:90990782 G/T cg03599575 chr15:90893182 GABARAPL3 0.34 5.86 0.31 1.13e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg07677032 chr17:61819896 STRADA 0.53 9.02 0.44 1.56e-17 Prudent dietary pattern; LUSC cis rs12210905 0.688 rs12193557 chr6:27435944 T/C cg08851530 chr6:28072375 NA 0.95 5.82 0.3 1.37e-8 Hip circumference adjusted for BMI; LUSC cis rs2303282 0.716 rs2920704 chr16:56441862 A/G cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.88e-12 Breast cancer; LUSC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg19774624 chr17:42201019 HDAC5 -0.65 -9.08 -0.45 9.46e-18 Total body bone mineral density; LUSC cis rs7188861 0.768 rs243315 chr16:11385011 C/T cg00044050 chr16:11439710 C16orf75 0.56 6.1 0.32 2.97e-9 HDL cholesterol; LUSC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.24 0.45 2.87e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg02527881 chr3:46936655 PTH1R -0.43 -7.67 -0.39 1.85e-13 Colorectal cancer; LUSC cis rs78366141 0.536 rs80239864 chr4:89698183 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.88 6.47 0.33 3.55e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs926938 0.541 rs360623 chr1:115407268 G/C cg01522456 chr1:115632236 TSPAN2 -0.39 -5.79 -0.3 1.59e-8 Autism; LUSC cis rs72777070 0.895 rs12615784 chr2:9789403 A/G cg14973360 chr2:9800511 NA -0.5 -6.69 -0.34 9.24e-11 Platelet-derived growth factor BB levels; LUSC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs3859192 0.599 rs34342173 chr17:38161507 T/C cg17467752 chr17:38218738 THRA -0.49 -6.87 -0.35 3.12e-11 White blood cell count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16229772 chr11:535615 HRAS -0.42 -6.45 -0.33 4.04e-10 Electrocardiographic conduction measures; LUSC cis rs2708977 0.901 rs2579505 chr2:97167962 T/C cg01950434 chr2:97203154 ARID5A -0.54 -8.04 -0.4 1.62e-14 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.79 -0.57 9.28e-31 Platelet count; LUSC cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.23 -0.37 3.33e-12 Menarche (age at onset); LUSC cis rs10782582 0.609 rs5745469 chr1:76347394 G/A cg10523679 chr1:76189770 ACADM -0.43 -6.22 -0.32 1.46e-9 Daytime sleep phenotypes; LUSC cis rs7582720 1.000 rs72934537 chr2:203969504 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.7 0.43 1.56e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2413583 0.591 rs114556035 chr22:39734647 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.64 5.82 0.3 1.39e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg00431813 chr7:1051703 C7orf50 -0.45 -7.25 -0.37 2.92e-12 Longevity;Endometriosis; LUSC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg12292205 chr6:26970375 C6orf41 -0.6 -7.36 -0.37 1.47e-12 Intelligence (multi-trait analysis); LUSC cis rs9527 0.590 rs2182348 chr10:104872684 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg03563238 chr19:33554763 RHPN2 -0.37 -6.25 -0.32 1.25e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg17366294 chr4:99064904 C4orf37 0.56 10.01 0.48 8.36e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg25643088 chr3:52874325 TMEM110 0.39 6.0 0.31 5.11e-9 Schizophrenia; LUSC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 8.52 0.42 5.5e-16 Melanoma; LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg07362569 chr17:61921086 SMARCD2 -0.38 -7.91 -0.4 3.84e-14 Prudent dietary pattern; LUSC cis rs10791097 0.694 rs4936123 chr11:130740967 G/A cg12179176 chr11:130786555 SNX19 0.89 16.06 0.66 2.02e-43 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs240764 0.781 rs12212736 chr6:101151410 C/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.15 -0.32 2.16e-9 Neuroticism; LUSC cis rs796364 0.577 rs7574287 chr2:200680999 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.99 0.31 5.55e-9 Schizophrenia; LUSC cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg06784218 chr1:46089804 CCDC17 0.53 10.55 0.5 1.22e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11890956 chr21:40555474 PSMG1 1.04 20.73 0.75 5.84e-62 Cognitive function; LUSC cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg15744005 chr10:104629667 AS3MT -0.34 -6.93 -0.35 2.22e-11 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs2997447 0.655 rs1317709 chr1:26384690 A/C cg19633962 chr1:26362018 EXTL1 -0.55 -6.79 -0.35 5.03e-11 QRS complex (12-leadsum); LUSC cis rs7851660 0.809 rs7037324 chr9:100658318 A/G cg13688889 chr9:100608707 NA -0.54 -8.46 -0.42 8.24e-16 Strep throat; LUSC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg22875332 chr1:76189707 ACADM 0.76 10.15 0.49 2.87e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2932538 0.845 rs6682678 chr1:113206920 A/G cg22162597 chr1:113214053 CAPZA1 -0.68 -9.58 -0.46 2.23e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg14552801 chr7:65878734 NA -0.37 -5.65 -0.3 3.53e-8 Aortic root size; LUSC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg03354898 chr7:1950403 MAD1L1 0.31 6.18 0.32 1.89e-9 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.08 0.52 1.64e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg13256891 chr4:100009986 ADH5 0.52 7.09 0.36 8.03e-12 Smoking initiation; LUSC cis rs3857536 0.740 rs7751095 chr6:66891318 A/G cg07460842 chr6:66804631 NA -0.48 -6.72 -0.35 7.74e-11 Blood trace element (Cu levels); LUSC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg11301795 chr4:187892539 NA -0.81 -16.0 -0.66 3.69e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg21770322 chr7:97807741 LMTK2 -0.47 -8.38 -0.42 1.53e-15 Breast cancer; LUSC cis rs4443100 0.670 rs8139280 chr22:23405957 G/A cg21100191 chr22:23484243 RTDR1 0.56 6.91 0.35 2.43e-11 Serum parathyroid hormone levels; LUSC cis rs7267979 0.966 rs2263204 chr20:25377688 A/T cg08601574 chr20:25228251 PYGB -0.45 -6.89 -0.35 2.73e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2235642 0.691 rs2281235 chr16:1603535 T/C cg26528668 chr16:1614120 IFT140 0.47 8.13 0.41 8.24e-15 Coronary artery disease; LUSC cis rs9326248 0.861 rs1871757 chr11:117030581 A/T cg26566898 chr11:117069891 TAGLN 0.38 6.2 0.32 1.63e-9 Blood protein levels; LUSC cis rs72634258 0.796 rs6703955 chr1:8165975 C/G cg00042356 chr1:8021962 PARK7 -0.63 -7.87 -0.4 4.85e-14 Inflammatory bowel disease; LUSC cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg26647111 chr11:31128758 NA 0.43 6.11 0.32 2.77e-9 Red blood cell count; LUSC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs8102732 1.000 rs8102732 chr19:1023867 C/G cg13770691 chr19:1021866 C19orf6 0.46 6.87 0.35 3.08e-11 Eosinophil percentage of granulocytes; LUSC cis rs9517313 0.592 rs11069311 chr13:99202101 G/T cg07423050 chr13:99094983 FARP1 -0.53 -9.76 -0.47 5.79e-20 Neuroticism; LUSC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg25282410 chr6:160211355 TCP1;MRPL18 1.06 15.48 0.65 4.08e-41 Age-related macular degeneration (geographic atrophy); LUSC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg23262073 chr20:60523788 NA -0.43 -6.42 -0.33 4.79e-10 Body mass index; LUSC trans rs11165623 0.564 rs7541109 chr1:96995960 C/A cg10631902 chr5:14652156 NA -0.41 -6.06 -0.31 3.69e-9 Hip circumference;Waist circumference; LUSC cis rs539096 0.540 rs3011217 chr1:44303266 C/T cg15962314 chr1:44399869 ARTN -0.24 -5.78 -0.3 1.7e-8 Intelligence (multi-trait analysis); LUSC trans rs1005277 0.579 rs2474584 chr10:38416389 C/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.65 -0.47 1.39e-19 Extrinsic epigenetic age acceleration; LUSC cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg11993925 chr19:44307056 LYPD5 0.45 9.48 0.46 5.02e-19 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs7617480 0.648 rs4858830 chr3:48734002 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.59 8.98 0.44 2.08e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.23e-19 Chronic sinus infection; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08722104 chr11:47448306 PSMC3 0.42 6.26 0.32 1.18e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs34421088 0.548 rs2618443 chr8:11384556 A/G cg06636001 chr8:8085503 FLJ10661 -0.59 -9.16 -0.45 5.18e-18 Neuroticism; LUSC trans rs61931739 0.500 rs10844845 chr12:34381117 C/T cg13010199 chr12:38710504 ALG10B 0.57 9.03 0.44 1.35e-17 Morning vs. evening chronotype; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg00431813 chr7:1051703 C7orf50 -0.44 -7.02 -0.36 1.21e-11 Longevity;Endometriosis; LUSC cis rs9467773 1.000 rs9393731 chr6:26529374 C/T cg05738196 chr6:26577821 NA 0.82 15.81 0.65 1.93e-42 Intelligence (multi-trait analysis); LUSC cis rs2273669 0.667 rs11153147 chr6:109304058 A/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.19 -0.32 1.76e-9 Prostate cancer; LUSC cis rs10504229 0.679 rs72649132 chr8:58054615 G/A cg08219700 chr8:58056026 NA 0.57 6.78 0.35 5.49e-11 Developmental language disorder (linguistic errors); LUSC cis rs6121246 0.567 rs7361893 chr20:30200751 C/T cg18721089 chr20:30220636 NA -0.41 -6.49 -0.33 3.1e-10 Mean corpuscular hemoglobin; LUSC cis rs4704187 0.574 rs4704184 chr5:74471677 A/G cg03227963 chr5:74354835 NA 0.3 6.59 0.34 1.68e-10 Response to amphetamines; LUSC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg18512352 chr11:47633146 NA 0.48 9.94 0.48 1.45e-20 Subjective well-being; LUSC cis rs765787 0.530 rs12915804 chr15:45512562 T/C cg24006582 chr15:45444508 DUOX1 0.67 9.7 0.47 9.32e-20 Uric acid levels; LUSC cis rs6901250 0.589 rs684023 chr6:117092308 T/C cg12892004 chr6:117198278 RFX6 0.37 6.62 0.34 1.48e-10 C-reactive protein levels; LUSC trans rs1005277 0.505 rs200937 chr10:38135772 T/C cg17830980 chr10:43048298 ZNF37B -0.43 -6.64 -0.34 1.26e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg11752832 chr7:134001865 SLC35B4 0.55 8.51 0.42 5.91e-16 Mean platelet volume; LUSC cis rs3096299 0.802 rs3102336 chr16:89442006 C/T cg00750074 chr16:89608354 SPG7 -0.46 -7.47 -0.38 7.17e-13 Multiple myeloma (IgH translocation); LUSC cis rs2219968 0.962 rs9643734 chr8:78950552 C/T cg00738934 chr8:78996279 NA 0.37 6.65 0.34 1.21e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs11958404 0.932 rs6895484 chr5:157429159 T/C cg05962755 chr5:157440814 NA 0.54 6.35 0.33 7.18e-10 IgG glycosylation; LUSC cis rs6741892 0.793 rs34391548 chr2:38906486 G/A cg23643435 chr2:38893251 GALM -0.75 -5.93 -0.31 7.55e-9 5-HTT brain serotonin transporter levels; LUSC cis rs28735056 0.620 rs12456484 chr18:77677315 C/G cg20368463 chr18:77673604 PQLC1 0.68 10.63 0.5 6.46e-23 Schizophrenia; LUSC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg22920501 chr2:26401640 FAM59B 0.68 9.9 0.48 1.98e-20 Gut microbiome composition (summer); LUSC cis rs9463078 0.683 rs911524 chr6:44747204 G/A cg25276700 chr6:44698697 NA 0.32 6.29 0.33 9.73e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1005277 0.505 rs200931 chr10:38128434 A/C cg00409905 chr10:38381863 ZNF37A -0.37 -6.23 -0.32 1.38e-9 Extrinsic epigenetic age acceleration; LUSC cis rs1904096 0.506 rs2632412 chr4:95149319 A/C cg11021082 chr4:95130006 SMARCAD1 0.39 7.02 0.36 1.26e-11 Type 2 diabetes; LUSC cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg26446133 chr18:72167187 CNDP2 -0.8 -9.81 -0.47 3.97e-20 Refractive error; LUSC trans rs6951245 1.000 rs76129108 chr7:1089159 G/A cg13565492 chr6:43139072 SRF -0.57 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg24881330 chr22:46731750 TRMU 0.9 10.18 0.49 2.17e-21 LDL cholesterol;Cholesterol, total; LUSC trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21659725 chr3:3221576 CRBN -0.59 -8.86 -0.44 4.84e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23248424 chr5:179741104 GFPT2 -0.57 -8.9 -0.44 3.53e-17 Height; LUSC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19717773 chr7:2847554 GNA12 -0.43 -7.48 -0.38 6.67e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg22800045 chr5:56110881 MAP3K1 0.78 9.71 0.47 8.45e-20 Initial pursuit acceleration; LUSC cis rs7107174 1.000 rs2512541 chr11:77981747 A/T cg02023728 chr11:77925099 USP35 0.46 6.65 0.34 1.23e-10 Testicular germ cell tumor; LUSC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg16680214 chr1:154839983 KCNN3 -0.51 -9.63 -0.47 1.55e-19 Prostate cancer; LUSC cis rs10979 1.000 rs12203151 chr6:143884856 C/T cg25407410 chr6:143891975 LOC285740 -0.74 -11.83 -0.54 3.36e-27 Hypospadias; LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg00814883 chr7:100076585 TSC22D4 -0.74 -9.33 -0.45 1.56e-18 Platelet count; LUSC cis rs3126085 0.935 rs4845745 chr1:152185184 C/T cg03465714 chr1:152285911 FLG -0.42 -5.88 -0.31 9.75e-9 Atopic dermatitis; LUSC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg24813613 chr7:1882135 MAD1L1 -0.44 -7.33 -0.37 1.76e-12 Bipolar disorder and schizophrenia; LUSC cis rs62400317 0.859 rs10456542 chr6:45107579 G/A cg20913747 chr6:44695427 NA -0.47 -7.57 -0.38 3.61e-13 Total body bone mineral density; LUSC cis rs6669072 1.000 rs10922923 chr1:91248029 A/T cg08895590 chr1:91227319 NA -0.36 -8.14 -0.41 7.85e-15 Cognitive function; LUSC cis rs79149102 0.579 rs6495142 chr15:75320166 C/T cg09165964 chr15:75287851 SCAMP5 -0.93 -8.84 -0.44 5.7e-17 Lung cancer; LUSC cis rs4780401 0.527 rs4780402 chr16:11839809 C/T cg01061890 chr16:11836724 TXNDC11 -0.51 -7.41 -0.38 1.05e-12 Rheumatoid arthritis; LUSC cis rs9420 0.961 rs7117205 chr11:57641883 A/G cg02958346 chr11:57425731 CLP1 -0.46 -6.52 -0.34 2.57e-10 Schizophrenia; LUSC trans rs7726839 0.540 rs11739847 chr5:609661 G/A cg11887960 chr12:57824829 NA 0.54 6.7 0.34 8.71e-11 Obesity-related traits; LUSC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.45 6.77 0.35 5.69e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs601339 0.838 rs2454702 chr12:123209159 C/T cg11919336 chr12:123188078 GPR109A 0.41 6.34 0.33 7.28e-10 Adiponectin levels; LUSC cis rs394563 0.602 rs409111 chr6:149766860 A/G cg11245181 chr6:149772854 ZC3H12D -0.3 -6.57 -0.34 1.96e-10 Dupuytren's disease; LUSC cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.38 0.37 1.23e-12 Motion sickness; LUSC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg24531977 chr5:56204891 C5orf35 -0.66 -9.73 -0.47 7.11e-20 Coronary artery disease; LUSC cis rs7818345 0.967 rs11787230 chr8:19280982 C/G cg11303988 chr8:19266685 CSGALNACT1 0.38 7.36 0.37 1.44e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg02951883 chr7:2050386 MAD1L1 -0.58 -10.65 -0.5 5.31e-23 Schizophrenia; LUSC cis rs62400317 0.762 rs12193264 chr6:44930793 T/C cg18551225 chr6:44695536 NA -0.45 -7.23 -0.37 3.38e-12 Total body bone mineral density; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg21280719 chr6:42927975 GNMT -0.34 -8.61 -0.43 2.86e-16 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs73019876 0.869 rs1849006 chr19:22142764 A/C cg16204205 chr18:19753432 GATA6 0.32 6.14 0.32 2.3e-9 Testicular germ cell tumor; LUSC trans rs7581030 0.517 rs4314015 chr2:71528309 G/T cg06465196 chr4:154387603 KIAA0922 0.42 6.04 0.31 4.18e-9 Testicular germ cell tumor; LUSC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg24881330 chr22:46731750 TRMU 0.82 7.29 0.37 2.32e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg05347473 chr6:146136440 FBXO30 0.49 8.04 0.4 1.6e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs6582630 0.555 rs11503799 chr12:38294578 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.35 -0.42 1.8e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs1506636 1.000 rs1506636 chr7:123317140 C/T cg03229431 chr7:123269106 ASB15 0.64 10.51 0.5 1.59e-22 Plateletcrit;Platelet count; LUSC cis rs1577917 0.958 rs2324839 chr6:86536942 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.98 -0.44 1.99e-17 Response to antipsychotic treatment; LUSC cis rs3096299 0.679 rs3102338 chr16:89442250 C/G cg00750074 chr16:89608354 SPG7 -0.46 -7.47 -0.38 7.02e-13 Multiple myeloma (IgH translocation); LUSC cis rs3925075 1.000 rs9673404 chr16:31347592 A/T cg02846316 chr16:31340340 ITGAM 0.36 6.66 0.34 1.11e-10 IgA nephropathy; LUSC cis rs765787 0.530 rs11858988 chr15:45522114 T/C cg25801113 chr15:45476975 SHF 0.34 7.07 0.36 9.18e-12 Uric acid levels; LUSC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg17366294 chr4:99064904 C4orf37 0.54 8.83 0.43 6.14e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs2414856 0.510 rs112523289 chr15:64905835 C/T cg08069370 chr15:64387884 SNX1 -0.65 -5.75 -0.3 2.03e-8 Pulse pressure;Systolic blood pressure; LUSC cis rs838147 0.508 rs507766 chr19:49208543 T/C cg21064579 chr19:49206444 FUT2 0.44 8.42 0.42 1.14e-15 Dietary macronutrient intake; LUSC cis rs10426930 0.690 rs710956 chr19:5054510 T/C cg15820610 chr19:5044198 KDM4B -0.41 -6.25 -0.32 1.26e-9 Monocyte percentage of white cells; LUSC cis rs7914558 1.000 rs10883837 chr10:104896486 G/A cg23093090 chr10:104574429 C10orf26 -0.38 -7.09 -0.36 8.04e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg14092988 chr3:52407081 DNAH1 0.31 6.12 0.32 2.56e-9 Bipolar disorder; LUSC cis rs2070488 0.965 rs1065800 chr3:38566480 C/T cg24069376 chr3:38537580 EXOG -0.46 -9.54 -0.46 3.08e-19 Electrocardiographic conduction measures; LUSC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg23625390 chr15:77176239 SCAPER 0.51 7.83 0.39 6.5e-14 Blood metabolite levels; LUSC cis rs1113500 0.509 rs17020915 chr1:108647006 G/T cg06207961 chr1:108661230 NA 0.35 5.65 0.3 3.5e-8 Growth-regulated protein alpha levels; LUSC cis rs4629180 0.701 rs10202801 chr2:102106670 T/C cg01388757 chr2:102091195 RFX8 -0.36 -6.26 -0.32 1.19e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg23093090 chr10:104574429 C10orf26 -0.37 -7.04 -0.36 1.12e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7940866 0.678 rs61909201 chr11:130839547 C/T cg12179176 chr11:130786555 SNX19 0.56 8.13 0.41 8.25e-15 Schizophrenia; LUSC cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg24692254 chr21:30365293 RNF160 0.78 13.98 0.61 2.84e-35 Dental caries; LUSC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.6 -7.48 -0.38 6.84e-13 Lung function (FEV1/FVC); LUSC cis rs17401966 0.540 rs11121566 chr1:10472848 C/G cg17425144 chr1:10567563 PEX14 -0.32 -5.66 -0.3 3.31e-8 Hepatocellular carcinoma; LUSC cis rs2414856 0.510 rs72757002 chr15:64615024 C/A cg08069370 chr15:64387884 SNX1 -0.73 -6.43 -0.33 4.3e-10 Pulse pressure;Systolic blood pressure; LUSC trans rs6951245 1.000 rs78861357 chr7:1095418 C/T cg13565492 chr6:43139072 SRF -0.61 -6.4 -0.33 5.21e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg23583168 chr7:148888333 NA -0.85 -14.83 -0.63 1.36e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9790314 0.695 rs7630763 chr3:160864865 T/C cg03342759 chr3:160939853 NMD3 -0.44 -7.37 -0.37 1.34e-12 Morning vs. evening chronotype; LUSC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs4499344 0.556 rs259227 chr19:33134791 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.93 13.74 0.6 2.35e-34 Mean platelet volume; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg15147215 chr3:52552868 STAB1 -0.34 -6.8 -0.35 4.95e-11 Electroencephalogram traits; LUSC trans rs7824557 1.000 rs2736371 chr8:11105529 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.1 -0.41 1.01e-14 Retinal vascular caliber; LUSC cis rs6940638 0.956 rs72838268 chr6:27021173 A/G cg09904177 chr6:26538194 HMGN4 -0.49 -5.7 -0.3 2.64e-8 Intelligence (multi-trait analysis); LUSC cis rs9479482 1.000 rs13198863 chr6:150350781 T/G cg00432049 chr6:150390894 ULBP3 -0.27 -5.76 -0.3 1.93e-8 Alopecia areata; LUSC cis rs7520050 0.778 rs12404197 chr1:46232420 G/A cg24296786 chr1:45957014 TESK2 0.41 5.84 0.3 1.24e-8 Red blood cell count;Reticulocyte count; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25626869 chr8:93978374 C8orf83 0.48 7.01 0.36 1.34e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.62 0.5 6.6e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs748404 0.650 rs556851 chr15:43571219 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.43 5.99 0.31 5.34e-9 Lung cancer; LUSC cis rs754466 0.580 rs11002301 chr10:79574078 G/A cg17075019 chr10:79541650 NA -0.76 -12.24 -0.56 1.03e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.12 0.52 1.15e-24 Menopause (age at onset); LUSC cis rs9303401 0.659 rs17822735 chr17:56620167 C/T cg25039879 chr17:56429692 SUPT4H1 0.69 9.14 0.45 6.35e-18 Cognitive test performance; LUSC cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg13798780 chr7:105162888 PUS7 0.56 6.16 0.32 2.11e-9 Bipolar disorder (body mass index interaction); LUSC cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.08 -0.36 8.55e-12 Menopause (age at onset); LUSC cis rs10078 0.571 rs2671890 chr5:456457 A/G cg08916839 chr5:415575 AHRR 0.75 7.09 0.36 7.88e-12 Fat distribution (HIV); LUSC cis rs7580658 0.963 rs2090574 chr2:128131391 C/A cg09760422 chr2:128146352 NA -0.33 -7.25 -0.37 2.91e-12 Protein C levels; LUSC cis rs12291225 0.546 rs12795545 chr11:14355564 G/A cg05501817 chr11:14380813 RRAS2 -0.57 -9.51 -0.46 4e-19 Sense of smell; LUSC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.86 -0.54 2.59e-27 Extrinsic epigenetic age acceleration; LUSC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg12564285 chr5:131593104 PDLIM4 0.37 6.85 0.35 3.53e-11 Blood metabolite levels; LUSC cis rs4737010 0.530 rs4026 chr8:41645710 C/T cg17182837 chr8:41585554 ANK1 -0.35 -6.34 -0.33 7.44e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC trans rs7944735 0.517 rs11039520 chr11:48130794 A/G cg15704280 chr7:45808275 SEPT13 0.69 6.34 0.33 7.4e-10 Intraocular pressure; LUSC cis rs2806561 0.704 rs1757039 chr1:23508657 A/G cg12483005 chr1:23474871 LUZP1 0.42 6.45 0.33 3.98e-10 Height; LUSC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg00745463 chr17:30367425 LRRC37B -0.64 -7.81 -0.39 7.55e-14 Hip circumference adjusted for BMI; LUSC cis rs7914558 0.932 rs4307650 chr10:104959852 C/A cg05855489 chr10:104503620 C10orf26 0.59 9.63 0.47 1.63e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11644478 chr21:40555479 PSMG1 -0.63 -9.59 -0.46 2.12e-19 Menarche (age at onset); LUSC cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg13010199 chr12:38710504 ALG10B 0.69 11.55 0.53 3.31e-26 Heart rate; LUSC cis rs6750795 0.641 rs10933375 chr2:232367296 A/T cg19187155 chr2:232395269 NMUR1 -0.63 -8.52 -0.42 5.39e-16 Height; LUSC cis rs240764 0.853 rs11155498 chr6:101019551 G/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.19 -0.32 1.8e-9 Neuroticism; LUSC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg22467129 chr15:76604101 ETFA -0.48 -7.7 -0.39 1.54e-13 Blood metabolite levels; LUSC cis rs7503807 0.967 rs12949279 chr17:78558411 T/C cg09596252 chr17:78655493 RPTOR 0.39 6.31 0.33 8.81e-10 Obesity; LUSC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs637571 0.510 rs12575663 chr11:65574535 G/A cg26695010 chr11:65641043 EFEMP2 0.46 6.68 0.34 1.02e-10 Eosinophil percentage of white cells; LUSC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.73 -0.43 1.25e-16 Monocyte count; LUSC cis rs61931739 0.534 rs28548399 chr12:34188151 G/A cg06521331 chr12:34319734 NA -0.45 -7.38 -0.37 1.29e-12 Morning vs. evening chronotype; LUSC trans rs724744 0.710 rs1205942 chr6:22357011 T/C cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.43e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs28647808 0.786 rs4962136 chr9:136256794 A/G cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg21435336 chr19:17392852 ANKLE1 -0.43 -5.87 -0.31 1.07e-8 Systemic lupus erythematosus; LUSC cis rs75804782 0.641 rs72983834 chr2:239319895 G/A cg18131467 chr2:239335373 ASB1 -0.74 -6.64 -0.34 1.28e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs2637266 0.846 rs2637261 chr10:78320593 A/G cg18941641 chr10:78392320 NA -0.43 -7.99 -0.4 2.17e-14 Pulmonary function; LUSC cis rs11971779 0.584 rs34762928 chr7:139113168 T/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs66716358 0.710 rs12793949 chr11:44317265 C/T cg16977035 chr11:44330474 ALX4 0.34 5.65 0.3 3.36e-8 Monobrow; LUSC cis rs11677416 1.000 rs7570215 chr2:113527660 G/T cg27083787 chr2:113543245 IL1A 0.44 6.97 0.36 1.65e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs10740039 0.804 rs1837950 chr10:62444965 C/T cg18175470 chr10:62150864 ANK3 0.46 7.25 0.37 2.86e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs7178572 0.524 rs12904088 chr15:77399397 C/G cg22256960 chr15:77711686 NA -0.49 -7.66 -0.39 1.99e-13 Type 2 diabetes; LUSC cis rs12999616 0.817 rs7425883 chr2:98331521 C/G cg26665480 chr2:98280029 ACTR1B -0.52 -6.01 -0.31 4.82e-9 Colorectal cancer; LUSC cis rs2267137 0.835 rs2267133 chr22:29765382 A/T cg07256473 chr22:29710276 RASL10A 0.35 6.77 0.35 5.84e-11 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03934478 chr11:495069 RNH1 0.89 10.25 0.49 1.3e-21 Body mass index; LUSC cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg22676075 chr6:135203613 NA 0.59 9.32 0.45 1.67e-18 High light scatter reticulocyte percentage of red cells; LUSC trans rs7493 0.755 rs13223537 chr7:94966167 C/T cg03473377 chr10:33568029 NRP1 0.37 6.21 0.32 1.57e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs1005277 0.541 rs2263163 chr10:38389887 G/A cg17830980 chr10:43048298 ZNF37B -0.59 -9.56 -0.46 2.62e-19 Extrinsic epigenetic age acceleration; LUSC trans rs12761450 0.500 rs10740011 chr10:61890937 G/T cg04781339 chr21:44781686 NA 0.29 6.2 0.32 1.67e-9 Plasma amyloid beta peptide concentrations (ABx-42); LUSC cis rs9457247 0.602 rs12208359 chr6:167458455 G/A cg25258033 chr6:167368657 RNASET2 0.43 6.53 0.34 2.49e-10 Crohn's disease; LUSC cis rs7264396 1.000 rs224436 chr20:34154124 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.19 -0.37 4.16e-12 Total cholesterol levels; LUSC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg15790184 chr11:494944 RNH1 0.4 6.2 0.32 1.65e-9 Systemic lupus erythematosus; LUSC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg22508957 chr16:3507546 NAT15 0.93 10.43 0.5 3.22e-22 Tuberculosis; LUSC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg11752832 chr7:134001865 SLC35B4 0.51 7.79 0.39 8.66e-14 Mean platelet volume; LUSC cis rs7733403 1 rs7733403 chr5:140154215 A/G cg26395211 chr5:140044315 WDR55 -0.38 -5.82 -0.3 1.4e-8 Schizophrenia; LUSC cis rs8099014 1.000 rs7226817 chr18:56128289 T/A cg12907477 chr18:56117327 MIR122 0.44 6.99 0.36 1.52e-11 Platelet count; LUSC cis rs7503807 0.967 rs8064502 chr17:78562434 C/A cg09596252 chr17:78655493 RPTOR 0.39 6.43 0.33 4.36e-10 Obesity; LUSC cis rs11190604 1.000 rs3793706 chr10:102269085 A/C cg16342193 chr10:102329863 NA 0.34 6.26 0.32 1.21e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC trans rs9354352 0.935 rs9345749 chr6:66699892 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.58 -0.34 1.81e-10 Initial pursuit acceleration in psychotic disorders; LUSC trans rs61931739 0.658 rs4476006 chr12:34237154 A/C cg26384229 chr12:38710491 ALG10B 0.55 8.85 0.44 5.14e-17 Morning vs. evening chronotype; LUSC trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 9.72 0.47 7.7e-20 Intelligence (multi-trait analysis); LUSC cis rs7202877 0.706 rs247434 chr16:75445304 G/A cg04384234 chr16:75411784 CFDP1 0.65 8.43 0.42 1.04e-15 Type 2 diabetes;Type 1 diabetes; LUSC cis rs2562784 0.638 rs2585045 chr15:84306314 G/A cg17507749 chr15:85114479 UBE2QP1 0.58 5.65 0.3 3.53e-8 Height; LUSC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg09034736 chr1:150693464 HORMAD1 0.47 6.49 0.33 3.03e-10 Melanoma; LUSC cis rs3960554 0.674 rs112742093 chr7:75800597 T/C cg17325771 chr7:75508891 RHBDD2 -0.42 -5.92 -0.31 7.78e-9 Eotaxin levels; LUSC cis rs2346177 0.844 rs34791442 chr2:46655169 T/C cg02822958 chr2:46747628 ATP6V1E2 0.38 6.59 0.34 1.73e-10 HDL cholesterol; LUSC cis rs11696739 0.761 rs2254458 chr20:1551485 C/T cg02198625 chr20:1600641 SIRPB1 -0.26 -5.78 -0.3 1.76e-8 Mean platelet volume; LUSC cis rs965604 1.000 rs1964678 chr15:78754000 A/G cg18825076 chr15:78729989 IREB2 -0.42 -6.78 -0.35 5.38e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg10802521 chr3:52805072 NEK4 -0.55 -8.98 -0.44 2.01e-17 Electroencephalogram traits; LUSC cis rs208520 0.661 rs851466 chr6:66840476 A/G cg07460842 chr6:66804631 NA -1.13 -17.71 -0.7 5.82e-50 Exhaled nitric oxide output; LUSC trans rs3808502 0.549 rs11991139 chr8:11428395 C/T cg11608241 chr8:8085544 FLJ10661 -0.5 -7.11 -0.36 7.23e-12 Neuroticism; LUSC trans rs7618501 0.633 rs2353579 chr3:50027774 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.95 0.44 2.54e-17 Intelligence (multi-trait analysis); LUSC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22590775 chr19:49891494 CCDC155 0.57 8.23 0.41 4.15e-15 Multiple sclerosis; LUSC cis rs11112613 0.713 rs12580741 chr12:105941328 A/G cg03607813 chr12:105948248 NA -0.79 -11.85 -0.54 2.84e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs1023500 0.505 rs2143139 chr22:42614401 G/C cg04733989 chr22:42467013 NAGA 0.53 8.22 0.41 4.56e-15 Schizophrenia; LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg08736216 chr1:53307985 ZYG11A 0.3 6.2 0.32 1.64e-9 Monocyte count; LUSC cis rs9921338 0.923 rs4563054 chr16:11447546 T/G cg00044050 chr16:11439710 C16orf75 -0.52 -6.85 -0.35 3.55e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1003719 0.680 rs2835664 chr21:38573429 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC trans rs4332037 0.539 rs11764780 chr7:2020904 G/C cg25206134 chr2:45395956 NA 0.59 6.71 0.34 8.32e-11 Bipolar disorder; LUSC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg16325326 chr1:53192061 ZYG11B 0.74 12.76 0.57 1.23e-30 Monocyte count; LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.57 -8.7 -0.43 1.58e-16 Lymphocyte counts; LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg16325326 chr1:53192061 ZYG11B -0.83 -14.56 -0.62 1.63e-37 Monocyte count; LUSC cis rs56091001 0.528 rs9616387 chr22:50313219 G/A cg08270630 chr22:50330655 NA -0.63 -7.3 -0.37 2.06e-12 Acne (severe); LUSC trans rs7819412 0.715 rs35223712 chr8:11043926 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.14 -0.41 7.93e-15 Triglycerides; LUSC cis rs546131 0.928 rs483976 chr11:34840167 C/G cg11058730 chr11:34937778 PDHX;APIP 0.46 6.31 0.33 9.11e-10 Lung disease severity in cystic fibrosis; LUSC cis rs9467773 0.873 rs9295698 chr6:26566099 T/A cg05738196 chr6:26577821 NA 0.82 15.85 0.66 1.46e-42 Intelligence (multi-trait analysis); LUSC cis rs10089 1.000 rs72794396 chr5:127501386 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 10.88 0.51 8.55e-24 Ileal carcinoids; LUSC cis rs9527 0.590 rs1926037 chr10:104878010 A/C cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs6500602 0.964 rs13335685 chr16:4469284 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.46 5.9 0.31 8.95e-9 Schizophrenia; LUSC cis rs1728785 1.000 rs698717 chr16:68560199 A/G cg02508848 chr16:68573721 ZFP90 -0.42 -5.68 -0.3 2.96e-8 Ulcerative colitis; LUSC cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg20476274 chr7:133979776 SLC35B4 -0.77 -12.45 -0.56 1.67e-29 Mean platelet volume; LUSC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg21361702 chr7:150065534 REPIN1 -0.48 -6.66 -0.34 1.14e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg09021430 chr5:549028 NA -0.53 -6.97 -0.36 1.7e-11 Lung disease severity in cystic fibrosis; LUSC cis rs1044826 0.913 rs9849039 chr3:139147106 A/G cg00490450 chr3:139108681 COPB2 0.55 7.32 0.37 1.82e-12 Obesity-related traits; LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg14789911 chr21:47582049 C21orf56 -0.41 -6.52 -0.34 2.55e-10 Testicular germ cell tumor; LUSC cis rs11122272 0.735 rs2474623 chr1:231513993 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs7107174 1.000 rs2510043 chr11:77977481 C/G cg02023728 chr11:77925099 USP35 0.43 6.6 0.34 1.63e-10 Testicular germ cell tumor; LUSC cis rs17807624 0.964 rs13249843 chr8:11459018 G/T cg27411982 chr8:10470053 RP1L1 0.4 6.09 0.32 3.02e-9 Systemic lupus erythematosus; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26919459 chr4:79472874 ANXA3 0.44 6.83 0.35 3.91e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2115630 1.000 rs11073730 chr15:85354596 C/T cg11189052 chr15:85197271 WDR73 -0.45 -6.48 -0.33 3.33e-10 P wave terminal force; LUSC cis rs5769765 0.817 rs11912619 chr22:50317401 G/A cg26441486 chr22:50317300 CRELD2 0.49 7.25 0.37 2.87e-12 Schizophrenia; LUSC cis rs2282032 1.000 rs114316342 chr14:90736477 C/T cg14092571 chr14:90743983 NA 0.55 6.88 0.35 2.96e-11 Longevity; LUSC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg11764359 chr7:65958608 NA 0.7 10.69 0.5 3.82e-23 Aortic root size; LUSC trans rs11098499 0.826 rs12511640 chr4:120251248 T/C cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg13319975 chr6:146136371 FBXO30 -0.52 -7.86 -0.4 5.18e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs3960554 0.808 rs868555 chr7:75697418 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 9.5 0.46 4.12e-19 Eotaxin levels; LUSC cis rs11030122 0.702 rs17081 chr11:3987830 A/G cg08557956 chr11:4115526 RRM1 0.47 5.83 0.3 1.3e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg00254258 chr1:3105189 PRDM16 -0.31 -6.0 -0.31 5.15e-9 Migraine; LUSC cis rs4654899 0.802 rs76122612 chr1:21243059 C/T cg01072550 chr1:21505969 NA -0.47 -6.84 -0.35 3.87e-11 Superior frontal gyrus grey matter volume; LUSC cis rs12815613 0.961 rs1134464 chr12:121406574 C/A cg02403541 chr12:121454288 C12orf43 -0.46 -5.84 -0.3 1.21e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg22166914 chr1:53195759 ZYG11B -0.71 -12.23 -0.56 1.11e-28 Monocyte count; LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg19318889 chr4:1322082 MAEA 0.78 14.84 0.63 1.27e-38 Longevity; LUSC cis rs308447 0.576 rs10005301 chr4:123715055 A/G cg10495464 chr4:123653540 BBS12;LOC729338 -0.91 -15.03 -0.64 2.36e-39 Perceived unattractiveness to mosquitoes; LUSC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg12292205 chr6:26970375 C6orf41 -0.58 -7.35 -0.37 1.49e-12 Intelligence (multi-trait analysis); LUSC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg11812906 chr14:75593930 NEK9 -0.67 -11.46 -0.53 7.28e-26 Height; LUSC cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg03359095 chr20:61002866 C20orf151 -0.29 -5.77 -0.3 1.78e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs11098499 0.954 rs10034623 chr4:120397829 G/A cg09307838 chr4:120376055 NA 0.79 11.75 0.54 6.73e-27 Corneal astigmatism; LUSC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg24642844 chr7:1081250 C7orf50 -0.46 -7.52 -0.38 5.26e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6831352 0.729 rs4699718 chr4:100067791 G/A cg12011299 chr4:100065546 ADH4 -0.72 -10.43 -0.5 3.12e-22 Alcohol dependence; LUSC cis rs4363385 0.509 rs11576882 chr1:152918785 T/G cg25856811 chr1:152973957 SPRR3 -0.38 -6.16 -0.32 2.12e-9 Inflammatory skin disease; LUSC cis rs2980439 0.557 rs2921056 chr8:8319182 T/C cg15556689 chr8:8085844 FLJ10661 0.68 11.09 0.52 1.57e-24 Neuroticism; LUSC trans rs7618501 0.633 rs9866695 chr3:50069452 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.24 -0.45 3.03e-18 Intelligence (multi-trait analysis); LUSC cis rs1524927 0.966 rs1524928 chr7:96356794 C/T cg03808172 chr7:96339361 SHFM1 0.43 6.53 0.34 2.48e-10 Total body bone mineral density; LUSC cis rs870825 0.616 rs7680639 chr4:185652915 C/T cg04058563 chr4:185651563 MLF1IP -0.79 -11.92 -0.55 1.5e-27 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16638648 chr17:38083781 ORMDL3 -0.4 -6.05 -0.31 3.97e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.27 -0.41 3.15e-15 Neuroticism; LUSC cis rs9640161 0.658 rs74348353 chr7:150053655 C/A cg27494647 chr7:150038898 RARRES2 0.46 7.02 0.36 1.28e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg02034447 chr16:89574710 SPG7 0.4 5.96 0.31 6.41e-9 Multiple myeloma (IgH translocation); LUSC cis rs6964587 1.000 rs10228334 chr7:91713972 C/T cg01689657 chr7:91764605 CYP51A1 0.31 5.65 0.3 3.48e-8 Breast cancer; LUSC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg03354898 chr7:1950403 MAD1L1 -0.37 -7.13 -0.36 6.14e-12 Bipolar disorder and schizophrenia; LUSC trans rs12200782 0.674 rs12207224 chr6:26519280 A/T cg18180407 chr1:55047736 ACOT11 0.48 5.97 0.31 6.12e-9 Small cell lung carcinoma; LUSC cis rs1595825 0.891 rs58111212 chr2:198889896 T/C cg10547527 chr2:198650123 BOLL -0.52 -6.3 -0.33 9.56e-10 Ulcerative colitis; LUSC cis rs7267979 0.714 rs6132825 chr20:25238309 A/T cg08601574 chr20:25228251 PYGB 0.48 7.55 0.38 4.24e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg20891283 chr12:69753455 YEATS4 0.63 9.8 0.47 4.4e-20 Blood protein levels; LUSC cis rs1577917 0.958 rs13219504 chr6:86556917 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.72 -0.35 7.84e-11 Response to antipsychotic treatment; LUSC cis rs1009647 0.645 rs73271727 chr14:55600430 G/T cg04306507 chr14:55594613 LGALS3 0.45 6.18 0.32 1.83e-9 Testicular germ cell tumor; LUSC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 7.95 0.4 2.94e-14 Melanoma; LUSC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg21951975 chr1:209979733 IRF6 0.55 7.02 0.36 1.22e-11 Cleft lip with or without cleft palate; LUSC cis rs12458462 0.859 rs35493271 chr18:77448793 G/T cg11879182 chr18:77439856 CTDP1 0.72 11.98 0.55 8.99e-28 Monocyte count; LUSC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg04450456 chr4:17643702 FAM184B -0.39 -6.44 -0.33 4.08e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg05340658 chr4:99064831 C4orf37 0.57 9.45 0.46 6.02e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs7428 0.527 rs7607284 chr2:85547376 C/G cg24342717 chr2:85555507 TGOLN2 -0.74 -12.3 -0.56 6.28e-29 Ear protrusion; LUSC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg25036284 chr2:26402008 FAM59B -0.69 -9.57 -0.46 2.39e-19 Gut microbiome composition (summer); LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg26354017 chr1:205819088 PM20D1 0.48 6.98 0.36 1.63e-11 Prostate-specific antigen levels; LUSC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg12463550 chr7:65579703 CRCP -0.53 -7.72 -0.39 1.4e-13 Aortic root size; LUSC cis rs7617480 0.617 rs7610519 chr3:48746427 C/G cg07636037 chr3:49044803 WDR6 0.78 10.25 0.49 1.25e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs748404 0.697 rs492743 chr15:43560945 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 8.33 0.41 2.18e-15 Lung cancer; LUSC cis rs478304 0.580 rs11606947 chr11:65508237 A/C cg10518572 chr11:65560635 OVOL1 -0.26 -6.03 -0.31 4.24e-9 Acne (severe); LUSC cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg12935359 chr14:103987150 CKB -0.59 -8.75 -0.43 1.1e-16 Intelligence (multi-trait analysis); LUSC cis rs936229 1.000 rs4886615 chr15:75131661 A/G cg14664628 chr15:75095509 CSK -0.91 -14.12 -0.61 7.8e-36 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg21724239 chr8:58056113 NA 0.79 9.53 0.46 3.43e-19 Developmental language disorder (linguistic errors); LUSC trans rs12571093 0.803 rs2241969 chr10:70031010 C/T cg04882175 chr6:131122610 NA -0.54 -6.2 -0.32 1.65e-9 Optic nerve measurement (disc area); LUSC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs58235267 0.591 rs2162014 chr2:63345507 C/A cg17519650 chr2:63277830 OTX1 0.62 9.11 0.45 7.65e-18 Prostate-specific antigen levels (conditioned on lead SNPs); LUSC cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.64 -0.6 5.38e-34 Chronic sinus infection; LUSC trans rs9329221 0.716 rs11989640 chr8:10256054 A/G cg15556689 chr8:8085844 FLJ10661 -0.57 -7.65 -0.39 2.15e-13 Neuroticism; LUSC cis rs8072100 1.000 rs3809868 chr17:45750596 G/A cg25173405 chr17:45401733 C17orf57 0.38 6.13 0.32 2.52e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9467711 0.606 rs2076030 chr6:26426856 G/A cg09904177 chr6:26538194 HMGN4 -0.74 -6.83 -0.35 4.11e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs902774 0.515 rs2363635 chr12:53354622 T/C cg25025879 chr12:53359317 NA -0.47 -7.6 -0.38 2.98e-13 Prostate cancer; LUSC trans rs3749237 0.964 rs1799845 chr3:49847623 A/G cg21659725 chr3:3221576 CRBN 0.6 8.62 0.43 2.79e-16 Resting heart rate; LUSC cis rs950027 0.620 rs1049518 chr15:45653367 G/A cg21132104 chr15:45694354 SPATA5L1 0.42 6.13 0.32 2.45e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs9902453 0.808 rs56088359 chr17:28173659 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.16 0.45 5.44e-18 Coffee consumption (cups per day); LUSC cis rs7258465 0.965 rs271622 chr19:18629277 A/G cg11102782 chr19:18549136 ISYNA1 -0.32 -5.97 -0.31 6.12e-9 Breast cancer; LUSC cis rs977987 0.806 rs4638613 chr16:75425553 C/T cg04384234 chr16:75411784 CFDP1 -0.43 -7.05 -0.36 1.04e-11 Dupuytren's disease; LUSC cis rs7769051 1.000 rs10484629 chr6:133117870 A/C cg07930552 chr6:133119739 C6orf192 0.85 10.68 0.5 4.3e-23 Type 2 diabetes nephropathy; LUSC cis rs9400467 0.528 rs445349 chr6:111662102 C/T cg22127309 chr6:111907043 TRAF3IP2 0.37 6.97 0.36 1.71e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs2404602 0.647 rs7178250 chr15:77099107 T/C cg23625390 chr15:77176239 SCAPER -0.64 -9.88 -0.48 2.35e-20 Blood metabolite levels; LUSC cis rs2859741 0.546 rs3845491 chr1:37497521 C/T cg09363841 chr1:37513479 NA -0.38 -7.16 -0.36 5.31e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC trans rs12310956 0.532 rs1525897 chr12:33941033 C/T cg26384229 chr12:38710491 ALG10B 0.73 11.56 0.53 3.22e-26 Morning vs. evening chronotype; LUSC cis rs6500395 1.000 rs34844432 chr16:48682418 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.69e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.54 0.46 3.22e-19 Prudent dietary pattern; LUSC cis rs826838 0.935 rs980571 chr12:39127532 C/G cg26384229 chr12:38710491 ALG10B -0.81 -15.13 -0.64 9.06e-40 Heart rate; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg02018176 chr4:1364513 KIAA1530 0.56 10.58 0.5 9.19e-23 Longevity; LUSC cis rs7809950 0.817 rs4727679 chr7:107085018 T/C cg23024343 chr7:107201750 COG5 -0.7 -10.35 -0.49 5.7e-22 Coronary artery disease; LUSC cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.56 -8.65 -0.43 2.15e-16 Menarche (age at onset); LUSC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03264133 chr6:25882463 NA -0.55 -8.98 -0.44 2.02e-17 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.710 rs11249995 chr8:10238922 T/C cg06636001 chr8:8085503 FLJ10661 0.55 7.72 0.39 1.35e-13 Neuroticism; LUSC cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg12386194 chr3:101231763 SENP7 0.63 8.74 0.43 1.13e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg18357526 chr6:26021779 HIST1H4A -0.37 -5.78 -0.3 1.69e-8 Intelligence (multi-trait analysis); LUSC cis rs983392 0.679 rs655231 chr11:60013857 A/G cg24026212 chr11:59952134 MS4A6A -0.36 -6.22 -0.32 1.5e-9 Alzheimer's disease (late onset); LUSC trans rs3942852 0.545 rs7395231 chr11:48091689 T/C cg15704280 chr7:45808275 SEPT13 -0.62 -8.09 -0.4 1.09e-14 Acute lymphoblastic leukemia (childhood); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09654908 chr15:62989952 TLN2 -0.69 -6.16 -0.32 2.15e-9 Cognitive performance; LUSC cis rs2439831 0.850 rs10438303 chr15:44016417 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.77 6.87 0.35 3.07e-11 Lung cancer in ever smokers; LUSC cis rs2637266 0.935 rs2252652 chr10:78405022 C/T cg18941641 chr10:78392320 NA 0.38 6.81 0.35 4.41e-11 Pulmonary function; LUSC cis rs5758511 0.679 rs55867855 chr22:42623258 G/A cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.89 -0.31 9.19e-9 Birth weight; LUSC cis rs6542838 0.641 rs6741166 chr2:99534926 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.07 -0.32 3.51e-9 Fear of minor pain; LUSC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg23643435 chr2:38893251 GALM -0.66 -6.79 -0.35 5.29e-11 5-HTT brain serotonin transporter levels; LUSC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg24829409 chr8:58192753 C8orf71 -0.62 -8.05 -0.4 1.49e-14 Developmental language disorder (linguistic errors); LUSC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg21984481 chr17:79567631 NPLOC4 -0.54 -10.41 -0.5 3.57e-22 Eye color traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08753222 chr11:71934705 INPPL1 -0.41 -6.17 -0.32 2.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1371867 1.000 rs1371867 chr8:101330209 A/C cg06636551 chr8:101224915 SPAG1 -0.38 -7.06 -0.36 1e-11 Atrioventricular conduction; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18500192 chr3:19189930 KCNH8 -0.49 -6.71 -0.34 8.27e-11 Bipolar disorder and schizophrenia; LUSC cis rs3540 0.533 rs2256110 chr15:90971036 T/C cg22089800 chr15:90895588 ZNF774 0.62 9.66 0.47 1.26e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs3020736 0.500 rs8138678 chr22:42516229 A/G cg04733989 chr22:42467013 NAGA -0.61 -9.44 -0.46 6.64e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.7 -8.5 -0.42 6.26e-16 Glomerular filtration rate in chronic kidney disease; LUSC cis rs2688608 0.869 rs2633308 chr10:75653904 A/T cg23231163 chr10:75533350 FUT11 -0.36 -5.92 -0.31 8.03e-9 Inflammatory bowel disease; LUSC cis rs7539542 0.556 rs6692075 chr1:202881302 C/T cg19681188 chr1:202830198 LOC148709 0.39 5.8 0.3 1.54e-8 Mean platelet volume; LUSC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg02534363 chr3:47050950 NBEAL2 0.35 5.71 0.3 2.49e-8 Colorectal cancer; LUSC cis rs734999 0.545 rs10797441 chr1:2551660 T/G cg18932078 chr1:2524107 MMEL1 0.31 6.92 0.35 2.35e-11 Ulcerative colitis; LUSC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.05 0.44 1.21e-17 Prudent dietary pattern; LUSC cis rs1975991 0.597 rs715790 chr3:187985004 A/G cg17585528 chr3:187988060 LPP 0.36 5.68 0.3 2.94e-8 White matter integrity (bipolar disorder risk interaction); LUSC cis rs9393777 0.920 rs13196692 chr6:27379119 C/T cg09904177 chr6:26538194 HMGN4 -0.8 -6.07 -0.32 3.46e-9 Intelligence (multi-trait analysis); LUSC cis rs12824058 1.000 rs12824058 chr12:130804334 A/G cg24838063 chr12:130822603 PIWIL1 0.69 10.74 0.51 2.6e-23 Menopause (age at onset); LUSC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg00701064 chr4:6280414 WFS1 0.59 14.34 0.62 1.17e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9486719 1.000 rs12197411 chr6:97039621 G/A cg06623918 chr6:96969491 KIAA0776 -0.84 -10.5 -0.5 1.72e-22 Migraine;Coronary artery disease; LUSC trans rs1422110 0.616 rs6452688 chr5:85445038 C/T cg01787110 chr1:109008453 NBPF6 0.55 9.3 0.45 1.91e-18 Attention function in attention deficit hyperactive disorder; LUSC cis rs9326248 0.813 rs474488 chr11:117068977 A/G cg26566898 chr11:117069891 TAGLN 0.38 5.9 0.31 9.11e-9 Blood protein levels; LUSC cis rs6733011 0.530 rs7608889 chr2:99481350 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -5.94 -0.31 7.29e-9 Bipolar disorder; LUSC cis rs7523050 0.643 rs34114412 chr1:109402866 C/T cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18089134 chr4:130014711 C4orf33;SCLT1 -0.44 -6.32 -0.33 8.4e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg06219351 chr7:158114137 PTPRN2 0.5 9.02 0.44 1.46e-17 Calcium levels; LUSC cis rs12701220 0.739 rs2293523 chr7:1098518 G/A cg20821713 chr7:1055600 C7orf50 -0.49 -5.9 -0.31 8.74e-9 Bronchopulmonary dysplasia; LUSC cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg18681998 chr4:17616180 MED28 0.78 13.81 0.6 1.26e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs7937682 0.855 rs10891285 chr11:111527775 T/C cg18187862 chr3:45730750 SACM1L 0.55 7.02 0.36 1.27e-11 Primary sclerosing cholangitis; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.61 0.54 2.12e-26 Alzheimer's disease; LUSC cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg19875535 chr5:140030758 IK 0.48 7.8 0.39 8.07e-14 Depressive symptoms (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19863752 chr5:175970067 NA -0.48 -6.22 -0.32 1.46e-9 Bipolar disorder and schizophrenia; LUSC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg00809820 chr17:80708513 TBCD;FN3K -0.37 -6.49 -0.33 3.1e-10 Glycated hemoglobin levels; LUSC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg03732007 chr1:2071316 PRKCZ -0.54 -9.99 -0.48 9.71e-21 Height; LUSC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg16262614 chr3:133464971 TF 0.43 7.38 0.37 1.24e-12 Iron status biomarkers (transferrin levels); LUSC cis rs354225 0.544 rs4455200 chr2:54801591 T/A cg26097391 chr2:54893211 SPTBN1 0.46 6.93 0.35 2.21e-11 Schizophrenia; LUSC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.53 0.5 1.45e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs12210905 0.925 rs10456349 chr6:26975459 G/A cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg01171360 chr6:293285 DUSP22 -0.5 -7.54 -0.38 4.58e-13 Menopause (age at onset); LUSC cis rs72960926 0.744 rs3897895 chr6:74917550 C/T cg03266952 chr6:74778945 NA -0.85 -7.11 -0.36 7.08e-12 Metabolite levels (MHPG); LUSC cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg15506890 chr2:3487001 NA 0.47 7.65 0.39 2.19e-13 Neurofibrillary tangles; LUSC cis rs10992471 0.528 rs4744133 chr9:95226702 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.34 -6.01 -0.31 4.94e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs683250 1.000 rs558104 chr11:83276244 C/A cg26617787 chr11:123396133 GRAMD1B -0.32 -6.09 -0.32 3.14e-9 Subcortical brain region volumes; LUSC cis rs6964587 1.000 rs34043009 chr7:91578447 T/C cg22709100 chr7:91322751 NA -0.38 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg06238570 chr21:40685208 BRWD1 -0.57 -8.82 -0.43 6.66e-17 Menarche (age at onset); LUSC cis rs9517320 0.534 rs4772090 chr13:99150674 T/C cg20487152 chr13:99095054 FARP1 -0.43 -7.54 -0.38 4.61e-13 Longevity; LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.92 -0.44 3.14e-17 Bipolar disorder; LUSC cis rs3858526 0.834 rs7939099 chr11:5995792 G/A cg05234568 chr11:5960015 NA -0.59 -8.45 -0.42 9.26e-16 DNA methylation (variation); LUSC cis rs13720 0.556 rs151335 chr20:57579950 A/G cg23907860 chr20:57583709 CTSZ -0.57 -7.98 -0.4 2.3e-14 Platelet distribution width; LUSC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg16372103 chr5:203701 NA 0.44 5.81 0.3 1.43e-8 Breast cancer; LUSC cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.15 16.21 0.66 5.28e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4786125 0.804 rs6500850 chr16:6896389 A/T cg03623568 chr16:6915990 A2BP1 -0.39 -6.76 -0.35 6.23e-11 Heart rate variability traits (SDNN); LUSC cis rs8044868 0.586 rs7200854 chr16:72083318 G/A cg16579770 chr16:72058938 DHODH 0.34 5.77 0.3 1.86e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs722599 0.748 rs20578 chr14:75367807 C/T cg08847533 chr14:75593920 NEK9 -0.48 -6.91 -0.35 2.41e-11 IgG glycosylation; LUSC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg18758796 chr5:131593413 PDLIM4 -0.41 -7.04 -0.36 1.07e-11 Breast cancer; LUSC cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg02527881 chr3:46936655 PTH1R 0.68 13.5 0.59 1.91e-33 Birth weight; LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.51 7.83 0.39 6.42e-14 Prudent dietary pattern; LUSC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.98 -0.4 2.34e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg05472934 chr7:22766657 IL6 0.5 7.69 0.39 1.71e-13 Lung cancer; LUSC cis rs11098499 0.754 rs4107728 chr4:120253910 G/A cg24375607 chr4:120327624 NA 0.77 12.48 0.56 1.28e-29 Corneal astigmatism; LUSC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg22907277 chr7:1156413 C7orf50 0.68 7.3 0.37 2.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg06026331 chr20:60912101 LAMA5 -0.45 -6.02 -0.31 4.69e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg07092213 chr7:1199455 ZFAND2A -0.56 -8.52 -0.42 5.69e-16 Longevity;Endometriosis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08761102 chr2:38303844 CYP1B1 0.47 6.92 0.35 2.38e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs16976116 0.901 rs1050931 chr15:55497691 G/A cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4654899 0.897 rs710311 chr1:21062001 T/C cg01072550 chr1:21505969 NA -0.43 -6.43 -0.33 4.35e-10 Superior frontal gyrus grey matter volume; LUSC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.97 0.31 5.94e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11644478 chr21:40555479 PSMG1 -0.76 -13.57 -0.6 1.01e-33 Cognitive function; LUSC cis rs35146811 0.735 rs2272344 chr7:99786819 C/T cg19116668 chr7:99932089 PMS2L1 -0.33 -5.67 -0.3 3.17e-8 Coronary artery disease; LUSC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg26380479 chr7:97908229 NA 0.26 5.86 0.31 1.1e-8 Prostate cancer (SNP x SNP interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12559031 chr17:48046365 DLX4 0.45 7.16 0.36 5.02e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2692947 0.794 rs2692949 chr2:96673525 G/A cg22654517 chr2:96458247 NA 0.3 5.85 0.3 1.16e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg11494091 chr17:61959527 GH2 0.67 14.17 0.61 5.09e-36 Prudent dietary pattern; LUSC cis rs11997175 0.583 rs12680811 chr8:33778426 A/C ch.8.33884649F chr8:33765107 NA 0.5 7.63 0.39 2.41e-13 Body mass index; LUSC cis rs1784581 0.674 rs1784592 chr6:162387365 T/A cg17173639 chr6:162384350 PARK2 -0.66 -11.91 -0.55 1.63e-27 Itch intensity from mosquito bite; LUSC cis rs10186029 0.509 rs7592621 chr2:213941177 C/T cg08319019 chr2:214017104 IKZF2 -0.43 -6.21 -0.32 1.61e-9 Systemic sclerosis; LUSC cis rs4285028 0.948 rs34566912 chr3:121679626 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.66 -0.47 1.23e-19 Multiple sclerosis; LUSC cis rs977987 0.806 rs2161684 chr16:75479153 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.96 -0.36 1.8e-11 Dupuytren's disease; LUSC trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg01802117 chr1:53393560 SCP2 0.4 6.63 0.34 1.38e-10 Monocyte count; LUSC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg18252515 chr7:66147081 NA -1.21 -13.94 -0.61 4.07e-35 Diabetic kidney disease; LUSC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg06221963 chr1:154839813 KCNN3 -0.59 -13.47 -0.59 2.55e-33 Prostate cancer; LUSC cis rs868036 0.958 rs11635424 chr15:68037578 C/T cg05925327 chr15:68127851 NA -0.33 -5.91 -0.31 8.29e-9 Restless legs syndrome; LUSC cis rs9788682 0.748 rs569207 chr15:78873119 A/G cg06917634 chr15:78832804 PSMA4 0.49 5.83 0.3 1.33e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg13319975 chr6:146136371 FBXO30 0.51 7.63 0.39 2.49e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs27434 0.821 rs28337 chr5:96125314 A/T cg16492584 chr5:96139282 ERAP1 -0.52 -7.05 -0.36 1e-11 Ankylosing spondylitis; LUSC cis rs9815354 0.812 rs73069203 chr3:41938767 T/C cg03022575 chr3:42003672 ULK4 0.83 8.64 0.43 2.32e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg11502198 chr6:26597334 ABT1 0.71 11.86 0.54 2.64e-27 Intelligence (multi-trait analysis); LUSC cis rs7608623 0.773 rs3795944 chr2:23920545 A/G cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg09365446 chr1:150670422 GOLPH3L 0.47 6.91 0.35 2.47e-11 Melanoma; LUSC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg08200582 chr11:442649 ANO9 -0.57 -6.39 -0.33 5.63e-10 Body mass index; LUSC cis rs870825 0.929 rs1405940 chr4:185591481 A/G cg04058563 chr4:185651563 MLF1IP 0.82 11.84 0.54 3.17e-27 Blood protein levels; LUSC cis rs2279817 1.000 rs2279817 chr1:18021858 T/C cg21791023 chr1:18019539 ARHGEF10L -0.48 -6.58 -0.34 1.87e-10 Neuroticism; LUSC trans rs561341 1.000 rs2470267 chr17:30274132 G/A cg27661571 chr11:113659931 NA -0.59 -7.05 -0.36 1.06e-11 Hip circumference adjusted for BMI; LUSC cis rs72781680 1.000 rs72781665 chr2:24223086 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.16 0.32 2.05e-9 Lymphocyte counts; LUSC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg02487422 chr3:49467188 NICN1 0.44 7.04 0.36 1.12e-11 Resting heart rate; LUSC cis rs5769707 0.837 rs5770599 chr22:50019981 C/G cg10356904 chr22:49881777 NA -0.29 -6.45 -0.33 3.9e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg18876405 chr7:65276391 NA 0.54 8.33 0.41 2.06e-15 Aortic root size; LUSC trans rs11039798 0.623 rs635632 chr11:48399532 T/C cg03929089 chr4:120376271 NA -0.59 -6.27 -0.32 1.13e-9 Axial length; LUSC cis rs4285028 0.948 rs73855481 chr3:121676951 C/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.57 -0.46 2.41e-19 Multiple sclerosis; LUSC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg05340658 chr4:99064831 C4orf37 -0.67 -11.18 -0.52 7.15e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg03579872 chr1:53393473 SCP2 -0.39 -5.71 -0.3 2.46e-8 Monocyte count; LUSC cis rs17533156 0.612 rs62078287 chr17:75128493 C/T cg11416367 chr17:75137675 SEC14L1 0.5 5.96 0.31 6.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4786125 0.879 rs11645781 chr16:6896128 C/T cg03623568 chr16:6915990 A2BP1 0.39 6.56 0.34 2.06e-10 Heart rate variability traits (SDNN); LUSC cis rs5167 0.534 rs56803710 chr19:45481884 C/T cg25746394 chr19:45450501 APOC2 0.32 6.07 0.32 3.55e-9 Blood protein levels; LUSC cis rs1372520 1.000 rs1372520 chr4:90757505 T/C cg14346243 chr4:90757452 SNCA -0.44 -6.28 -0.32 1.08e-9 Neuroticism; LUSC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.33e-10 Height; LUSC cis rs8141529 0.509 rs5762863 chr22:29253335 A/C cg02153584 chr22:29168773 CCDC117 0.55 7.94 0.4 3.01e-14 Lymphocyte counts; LUSC cis rs1858740 0.509 rs196375 chr3:38422919 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.57 9.06 0.44 1.13e-17 Schizophrenia; LUSC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.59 -8.74 -0.43 1.13e-16 Mean platelet volume; LUSC trans rs35110281 0.811 rs2838339 chr21:45075750 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.66 -11.66 -0.54 1.43e-26 Mean corpuscular volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23162396 chr3:195808345 TFRC -0.46 -5.96 -0.31 6.27e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg07424592 chr7:64974309 NA 0.69 6.18 0.32 1.88e-9 Diabetic kidney disease; LUSC cis rs644799 0.710 rs12272061 chr11:95524067 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.86 0.6 8.34e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg00343986 chr7:65444356 GUSB -0.46 -6.88 -0.35 2.94e-11 Corneal structure; LUSC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg06238570 chr21:40685208 BRWD1 -0.58 -9.02 -0.44 1.46e-17 Menarche (age at onset); LUSC cis rs11039100 1.000 rs61875915 chr11:5828568 A/G cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10911232 0.507 rs3934578 chr1:183027216 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.15 0.52 9.13e-25 Hypertriglyceridemia; LUSC cis rs6424115 1.000 rs34477640 chr1:24154067 T/C cg10978503 chr1:24200527 CNR2 -0.49 -11.59 -0.54 2.39e-26 Immature fraction of reticulocytes; LUSC cis rs9303401 0.659 rs62083410 chr17:56964386 T/C cg25039879 chr17:56429692 SUPT4H1 0.68 9.11 0.45 7.7e-18 Cognitive test performance; LUSC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6736093 0.966 rs6743523 chr2:112693875 G/A cg12686935 chr2:112915763 FBLN7 -0.36 -5.84 -0.3 1.25e-8 Coronary artery disease; LUSC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg20243544 chr17:37824526 PNMT 0.57 8.19 0.41 5.64e-15 Asthma; LUSC cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.1e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg00509249 chr6:109615579 CCDC162 0.32 5.74 0.3 2.15e-8 Reticulocyte fraction of red cells; LUSC cis rs1163251 0.837 rs839612 chr1:120247176 T/C cg19096424 chr1:120255104 PHGDH 0.44 5.98 0.31 5.65e-9 Blood metabolite levels; LUSC cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.37 -6.7 -0.34 8.82e-11 Hematocrit; LUSC trans rs9503598 0.636 rs7745968 chr6:3467745 G/T cg05722439 chr19:14072965 RFX1 -0.3 -5.95 -0.31 6.8e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.72 0.43 1.34e-16 Prudent dietary pattern; LUSC cis rs929596 0.785 rs17864701 chr2:234652717 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.71 -12.24 -0.56 1.05e-28 Total bilirubin levels in HIV-1 infection; LUSC cis rs10089 0.953 rs72794400 chr5:127516028 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.61 0.54 2.04e-26 Ileal carcinoids; LUSC trans rs8072100 0.967 rs8072644 chr17:45653364 A/T cg03886242 chr7:26192032 NFE2L3 0.37 6.23 0.32 1.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6967385 0.560 rs10248602 chr7:12347113 G/C cg10578991 chr7:12443926 VWDE 0.39 5.73 0.3 2.26e-8 Response to taxane treatment (placlitaxel); LUSC cis rs77741769 0.529 rs525425 chr12:121195625 A/G cg02419362 chr12:121203948 SPPL3 0.46 8.38 0.42 1.47e-15 Mean corpuscular volume; LUSC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg21433313 chr16:3507492 NAT15 0.65 10.59 0.5 8.68e-23 Tuberculosis; LUSC cis rs4919087 0.620 rs793518 chr10:98986970 C/T cg25902810 chr10:99078978 FRAT1 -0.44 -6.14 -0.32 2.4e-9 Monocyte count; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10247162 chr16:15068775 PDXDC1 -0.47 -6.14 -0.32 2.35e-9 Hepatitis; LUSC cis rs977987 0.806 rs1549306 chr16:75415341 A/G cg03315344 chr16:75512273 CHST6 0.48 9.23 0.45 3.15e-18 Dupuytren's disease; LUSC cis rs1348850 0.914 rs4893938 chr2:178250095 T/C cg22681709 chr2:178499509 PDE11A -0.49 -8.93 -0.44 2.99e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24877558 chr1:42801138 FOXJ3 -0.49 -6.14 -0.32 2.4e-9 Bipolar disorder and schizophrenia; LUSC cis rs2932538 0.922 rs61818800 chr1:113148571 A/G cg22162597 chr1:113214053 CAPZA1 0.65 8.97 0.44 2.25e-17 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg06618935 chr21:46677482 NA -0.43 -8.2 -0.41 5.38e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs868036 0.957 rs9920662 chr15:68104297 G/A cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.38 7.72 0.39 1.36e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs9325144 0.647 rs11168104 chr12:38857616 G/T cg13010199 chr12:38710504 ALG10B -0.48 -7.29 -0.37 2.28e-12 Morning vs. evening chronotype; LUSC cis rs965469 0.779 rs6051693 chr20:3244449 T/G cg25506879 chr20:3388711 C20orf194 -0.49 -5.68 -0.3 2.88e-8 IFN-related cytopenia; LUSC trans rs61931739 0.635 rs10772123 chr12:33975557 C/T cg13010199 chr12:38710504 ALG10B 0.4 6.05 0.31 3.86e-9 Morning vs. evening chronotype; LUSC cis rs1784581 0.855 rs1893101 chr6:162384371 G/C cg17173639 chr6:162384350 PARK2 -0.84 -15.86 -0.66 1.23e-42 Itch intensity from mosquito bite; LUSC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg00074818 chr8:8560427 CLDN23 0.58 9.91 0.48 1.88e-20 Obesity-related traits; LUSC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg14584255 chr6:163149320 PACRG;PARK2 -0.51 -8.83 -0.44 5.94e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1003719 0.715 rs7282195 chr21:38508619 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.31 -0.49 7.77e-22 Eye color traits; LUSC cis rs117623576 0.941 rs72784857 chr10:32441029 C/T cg03047570 chr10:32398778 NA -0.57 -5.7 -0.3 2.57e-8 Anti-saccade response; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg00945038 chr17:61921165 SMARCD2 0.51 8.67 0.43 1.94e-16 Prudent dietary pattern; LUSC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg20203395 chr5:56204925 C5orf35 -0.82 -11.32 -0.53 2.28e-25 Initial pursuit acceleration; LUSC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.21 -0.49 1.74e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7267979 0.966 rs3002698 chr20:25303379 C/G cg08601574 chr20:25228251 PYGB -0.44 -6.78 -0.35 5.38e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs617219 0.853 rs1664552 chr5:78438492 A/C cg24856658 chr5:78533917 JMY -0.31 -5.74 -0.3 2.14e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs611744 0.647 rs589347 chr8:109253929 T/A cg21045802 chr8:109455806 TTC35 0.43 6.6 0.34 1.58e-10 Dupuytren's disease; LUSC cis rs137603 0.644 rs137636 chr22:39722477 C/A cg17798944 chr22:39715225 SNORD43;RPL3 -0.52 -8.34 -0.42 1.99e-15 Primary biliary cholangitis; LUSC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg15790184 chr11:494944 RNH1 0.52 5.98 0.31 5.62e-9 Body mass index; LUSC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg07741184 chr6:167504864 NA 0.43 7.65 0.39 2.19e-13 Crohn's disease; LUSC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs2933343 0.700 rs1680788 chr3:128625318 C/T cg11901034 chr3:128598214 ACAD9 -0.42 -6.66 -0.34 1.16e-10 IgG glycosylation; LUSC cis rs7267979 0.773 rs6132821 chr20:25226192 A/G cg08601574 chr20:25228251 PYGB 0.55 8.83 0.43 6.23e-17 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -7.25 -0.37 2.87e-12 Body mass index; LUSC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg06640241 chr16:89574553 SPG7 0.72 9.88 0.48 2.25e-20 Multiple myeloma (IgH translocation); LUSC cis rs11690935 0.549 rs62183819 chr2:172904520 G/T cg13550731 chr2:172543902 DYNC1I2 0.53 8.14 0.41 7.95e-15 Schizophrenia; LUSC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg25282410 chr6:160211355 TCP1;MRPL18 1.07 16.44 0.67 6.79e-45 Age-related macular degeneration (geographic atrophy); LUSC trans rs57221529 0.766 rs56278696 chr5:582669 A/G cg11887960 chr12:57824829 NA 0.56 6.84 0.35 3.75e-11 Lung disease severity in cystic fibrosis; LUSC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg21951975 chr1:209979733 IRF6 0.4 6.67 0.34 1.08e-10 Monobrow; LUSC cis rs2668423 0.501 rs502121 chr19:1387299 T/C cg02639931 chr19:1387894 NDUFS7 -0.67 -13.21 -0.59 2.49e-32 Nonalcoholic fatty liver disease; LUSC cis rs4132509 1.000 rs12116882 chr1:243959106 G/A cg21452805 chr1:244014465 NA 0.52 5.97 0.31 6.07e-9 RR interval (heart rate); LUSC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg04267008 chr7:1944627 MAD1L1 -0.45 -6.46 -0.33 3.61e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6426558 0.537 rs6699828 chr1:227274591 T/C cg10327440 chr1:227177885 CDC42BPA 0.55 7.46 0.38 7.53e-13 Neutrophil percentage of white cells; LUSC cis rs1670533 0.818 rs6835141 chr4:1070140 G/T cg27284194 chr4:1044797 NA 0.58 8.93 0.44 2.81e-17 Recombination rate (females); LUSC cis rs9326248 0.581 rs10892053 chr11:116857003 C/T cg26566898 chr11:117069891 TAGLN 0.35 6.56 0.34 2.05e-10 Blood protein levels; LUSC cis rs34891900 0.507 rs1008378 chr22:18207251 T/C cg19898043 chr22:18121309 BCL2L13 0.43 6.6 0.34 1.58e-10 Sum neutrophil eosinophil counts; LUSC trans rs10506458 0.915 rs12426308 chr12:63405778 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.48 -0.65 3.84e-41 Hemostatic factors and hematological phenotypes; LUSC cis rs524023 1.000 rs537246 chr11:64360630 G/A cg07220939 chr11:64358617 SLC22A12 0.23 6.08 0.32 3.35e-9 Urate levels in obese individuals; LUSC cis rs9902453 0.934 rs7213902 chr17:28322935 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.34 0.41 2.03e-15 Coffee consumption (cups per day); LUSC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg19592336 chr6:28129416 ZNF389 0.45 5.81 0.3 1.46e-8 Depression; LUSC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg07701084 chr6:150067640 NUP43 -0.57 -8.98 -0.44 1.97e-17 Lung cancer; LUSC cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC trans rs9329221 0.513 rs4841296 chr8:10105447 C/G cg15556689 chr8:8085844 FLJ10661 -0.55 -8.17 -0.41 6.33e-15 Neuroticism; LUSC cis rs8040855 0.756 rs2342118 chr15:85693016 C/T cg04831495 chr15:85060580 GOLGA6L5 0.42 6.45 0.33 3.95e-10 Bulimia nervosa; LUSC cis rs367943 0.712 rs9326887 chr5:112728581 T/A cg12552261 chr5:112820674 MCC 0.36 5.84 0.3 1.21e-8 Type 2 diabetes; LUSC cis rs533581 0.866 rs871756 chr16:88969076 G/C cg16701003 chr16:89028210 CBFA2T3 0.34 5.91 0.31 8.53e-9 Social autistic-like traits; LUSC cis rs10197940 0.662 rs1047957 chr2:152333773 C/T cg19508488 chr2:152266495 RIF1 0.44 6.33 0.33 8.07e-10 Lung cancer; LUSC cis rs3106136 0.967 rs2664892 chr4:95154186 T/C cg11021082 chr4:95130006 SMARCAD1 -0.34 -5.93 -0.31 7.72e-9 Capecitabine sensitivity; LUSC cis rs9646944 0.501 rs10166330 chr2:103050390 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.55 0.34 2.23e-10 Blood protein levels; LUSC cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg05043794 chr9:111880884 C9orf5 -0.33 -6.97 -0.36 1.72e-11 Menarche (age at onset); LUSC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg27432699 chr2:27873401 GPN1 -0.56 -8.41 -0.42 1.23e-15 Total body bone mineral density; LUSC cis rs9807989 0.839 rs4988957 chr2:102968075 C/T cg09003973 chr2:102972529 NA -0.44 -5.98 -0.31 5.86e-9 Asthma; LUSC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg22920501 chr2:26401640 FAM59B -0.8 -11.76 -0.54 6.2e-27 Gut microbiome composition (summer); LUSC cis rs1577917 0.958 rs12660846 chr6:86573809 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.93 -0.35 2.13e-11 Response to antipsychotic treatment; LUSC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs9650657 0.562 rs10090444 chr8:10745469 C/G cg27411982 chr8:10470053 RP1L1 0.48 7.21 0.37 3.68e-12 Neuroticism; LUSC trans rs4729127 1.000 rs7793690 chr7:94013594 A/T cg20086523 chr13:52378287 DHRS12 0.56 6.35 0.33 6.97e-10 Intelligence; LUSC trans rs853679 1.000 rs1778508 chr6:28229881 C/T cg06606381 chr12:133084897 FBRSL1 0.56 6.57 0.34 1.98e-10 Depression; LUSC cis rs28595532 0.702 rs72670250 chr4:119337134 T/C cg21605333 chr4:119757512 SEC24D 1.02 8.31 0.41 2.47e-15 Cannabis dependence symptom count; LUSC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg20503657 chr10:835505 NA 1.22 16.05 0.66 2.2e-43 Eosinophil percentage of granulocytes; LUSC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg27535305 chr1:53392650 SCP2 -0.39 -7.36 -0.37 1.43e-12 Monocyte count; LUSC cis rs7208859 0.623 rs9897728 chr17:29108804 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg02807482 chr3:125708958 NA -0.53 -7.07 -0.36 9.31e-12 Blood pressure (smoking interaction); LUSC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg03351412 chr1:154909251 PMVK -0.43 -6.55 -0.34 2.19e-10 Prostate cancer; LUSC cis rs7267979 0.844 rs2424703 chr20:25270124 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.77 16.18 0.66 7.08e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9905704 0.589 rs2680696 chr17:56473013 C/T cg19466818 chr17:56409534 MIR142 0.31 5.86 0.31 1.09e-8 Testicular germ cell tumor; LUSC cis rs9527 0.590 rs1935323 chr10:104877035 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.02 0.4 1.81e-14 Arsenic metabolism; LUSC trans rs11250098 0.567 rs4326350 chr8:10763655 C/G cg06636001 chr8:8085503 FLJ10661 0.51 7.08 0.36 8.75e-12 Morning vs. evening chronotype; LUSC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.47 0.53 6.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6961069 0.671 rs10261849 chr7:80224467 A/C cg04458919 chr7:80252533 CD36 -0.41 -7.25 -0.37 2.89e-12 Platelet count; LUSC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg11645453 chr3:52864694 ITIH4 -0.5 -11.33 -0.53 2.17e-25 Schizophrenia; LUSC cis rs599083 0.530 rs2472415 chr11:68185616 T/C cg01657329 chr11:68192670 LRP5 0.48 6.32 0.33 8.42e-10 Bone mineral density (spine); LUSC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg12379764 chr21:47803548 PCNT 0.63 9.23 0.45 3.08e-18 Testicular germ cell tumor; LUSC cis rs478607 1.000 rs551890 chr11:64477999 C/T cg19131476 chr11:64387923 NRXN2 -0.32 -5.82 -0.3 1.38e-8 Urate levels; LUSC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg22105103 chr4:187893119 NA 0.71 13.9 0.61 5.76e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs9462027 0.628 rs2395598 chr6:34640686 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.21 -0.32 1.53e-9 Systemic lupus erythematosus; LUSC cis rs8060686 0.641 rs79719939 chr16:68240216 A/G cg09835421 chr16:68378352 PRMT7 -0.54 -5.94 -0.31 7.01e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.26 0.32 1.16e-9 Electroencephalogram traits; LUSC cis rs7560272 0.669 rs7598660 chr2:73740425 C/T cg20560298 chr2:73613845 ALMS1 -0.39 -6.0 -0.31 5.27e-9 Schizophrenia; LUSC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg21880101 chr17:80066754 CCDC57 -0.31 -5.93 -0.31 7.5e-9 Life satisfaction; LUSC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg03289416 chr15:75166202 SCAMP2 0.38 5.66 0.3 3.28e-8 Caffeine consumption; LUSC cis rs208520 0.690 rs12202913 chr6:66734198 C/T cg07460842 chr6:66804631 NA 1.1 17.27 0.69 3.24e-48 Exhaled nitric oxide output; LUSC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs208520 0.545 rs10944874 chr6:66752080 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.14 -22.53 -0.78 5.51e-69 Exhaled nitric oxide output; LUSC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg01973587 chr1:228161476 NA -0.41 -7.15 -0.36 5.48e-12 Diastolic blood pressure; LUSC cis rs2404602 0.735 rs11629888 chr15:76719880 A/T cg23625390 chr15:77176239 SCAPER -0.63 -9.23 -0.45 3.2e-18 Blood metabolite levels; LUSC cis rs11229555 0.645 rs12283414 chr11:58176920 C/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.1 -0.41 1.03e-14 Chronic sinus infection; LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 9.8e-65 Prudent dietary pattern; LUSC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg05738196 chr6:26577821 NA 0.54 8.58 0.42 3.72e-16 Schizophrenia; LUSC cis rs3087591 0.810 rs2269856 chr17:29482701 C/T cg24425628 chr17:29625626 OMG;NF1 0.59 8.37 0.42 1.61e-15 Hip circumference; LUSC cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.07 -0.44 1.05e-17 Monocyte percentage of white cells; LUSC trans rs7937682 0.883 rs484834 chr11:111465761 G/C cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg06453172 chr10:134556979 INPP5A -0.48 -5.95 -0.31 6.62e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6121246 0.529 rs7261354 chr20:30202414 T/C cg18721089 chr20:30220636 NA -0.41 -6.49 -0.33 3.1e-10 Mean corpuscular hemoglobin; LUSC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs1506636 0.962 rs17623873 chr7:123417100 C/A cg03229431 chr7:123269106 ASB15 0.63 10.1 0.48 4.34e-21 Plateletcrit;Platelet count; LUSC cis rs748404 0.723 rs560134 chr15:43555699 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.41 5.88 0.31 1e-8 Lung cancer; LUSC cis rs614226 1.000 rs1167727 chr12:120965508 C/A cg01236616 chr12:121019343 POP5 1.31 22.15 0.77 1.62e-67 Type 1 diabetes nephropathy; LUSC cis rs6977660 0.714 rs4719585 chr7:19823727 C/G cg07541023 chr7:19748670 TWISTNB 0.6 6.3 0.33 9.45e-10 Thyroid stimulating hormone; LUSC cis rs3806843 1.000 rs9686540 chr5:140174622 G/A cg19875535 chr5:140030758 IK 0.5 8.28 0.41 3.06e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs782590 0.935 rs62165197 chr2:55801812 C/T cg18811423 chr2:55921094 PNPT1 0.83 14.27 0.62 2.19e-36 Metabolic syndrome; LUSC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg06022373 chr22:39101656 GTPBP1 0.81 13.55 0.6 1.19e-33 Menopause (age at onset); LUSC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg18827107 chr12:86230957 RASSF9 -0.43 -6.37 -0.33 6.35e-10 Major depressive disorder; LUSC cis rs9361491 0.604 rs1158575 chr6:79459206 A/G cg05283184 chr6:79620031 NA -0.32 -5.86 -0.31 1.13e-8 Intelligence (multi-trait analysis); LUSC trans rs10771431 1.000 rs10771431 chr12:9380859 C/T cg27600084 chr12:12264075 NA 0.46 7.08 0.36 8.78e-12 Breast size; LUSC trans rs804280 0.543 rs13261205 chr8:11791216 A/G cg15556689 chr8:8085844 FLJ10661 0.58 8.8 0.43 7.22e-17 Myopia (pathological); LUSC cis rs4499344 0.577 rs259289 chr19:33164927 G/C cg22980127 chr19:33182716 NUDT19 -0.42 -6.3 -0.33 9.55e-10 Mean platelet volume; LUSC cis rs9300255 0.602 rs1716172 chr12:123712712 G/T cg05973401 chr12:123451056 ABCB9 0.53 6.59 0.34 1.73e-10 Neutrophil percentage of white cells; LUSC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg09796270 chr17:17721594 SREBF1 -0.4 -7.05 -0.36 1.06e-11 Total body bone mineral density; LUSC cis rs17270561 0.609 rs1165181 chr6:25825390 T/A cg17691542 chr6:26056736 HIST1H1C 0.49 7.02 0.36 1.28e-11 Iron status biomarkers; LUSC cis rs61931739 0.500 rs12832312 chr12:34031199 G/A cg06521331 chr12:34319734 NA -0.47 -7.68 -0.39 1.78e-13 Morning vs. evening chronotype; LUSC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.21 0.52 5.92e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs751728 1.000 rs943477 chr6:33750931 T/C cg25922239 chr6:33757077 LEMD2 0.53 7.82 0.39 7.07e-14 Crohn's disease; LUSC cis rs868036 1.000 rs6494696 chr15:68103206 C/G cg08079166 chr15:68083412 MAP2K5 -0.4 -8.01 -0.4 1.9e-14 Restless legs syndrome; LUSC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 12.92 0.58 2.98e-31 Platelet count; LUSC cis rs7586879 0.964 rs4077680 chr2:25122942 A/G cg01884057 chr2:25150051 NA 0.42 9.1 0.45 8.06e-18 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02331583 chr17:40021711 KLHL11 0.48 6.49 0.33 3.08e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs963731 0.649 rs2278913 chr2:39199880 A/G cg04010122 chr2:39346883 SOS1 -0.77 -5.67 -0.3 3.1e-8 Corticobasal degeneration; LUSC cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg05043794 chr9:111880884 C9orf5 -0.37 -7.81 -0.39 7.29e-14 Menarche (age at onset); LUSC cis rs950169 0.887 rs62029593 chr15:84955180 A/G cg12863693 chr15:85201151 NMB 0.36 7.06 0.36 9.44e-12 Schizophrenia; LUSC cis rs9325144 0.600 rs12297194 chr12:38735803 A/G cg26384229 chr12:38710491 ALG10B -0.6 -9.41 -0.46 8.44e-19 Morning vs. evening chronotype; LUSC cis rs6750047 0.605 rs2121260 chr2:38268763 T/G cg07380506 chr2:38303506 CYP1B1 0.44 6.0 0.31 5.02e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg09035930 chr12:129282057 SLC15A4 0.75 15.94 0.66 6.21e-43 Systemic lupus erythematosus; LUSC cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.65 10.1 0.48 4.15e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.45 6.97 0.36 1.66e-11 Schizophrenia; LUSC cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs911555 0.755 rs34411783 chr14:103900639 G/A cg12935359 chr14:103987150 CKB 0.65 10.46 0.5 2.5e-22 Intelligence (multi-trait analysis); LUSC cis rs10740039 0.804 rs10821824 chr10:62450207 G/T cg18175470 chr10:62150864 ANK3 -0.44 -6.67 -0.34 1.08e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs16867321 1.000 rs10185265 chr2:181438860 G/C cg23363182 chr2:181467187 NA -0.44 -5.91 -0.31 8.26e-9 Obesity; LUSC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg23791538 chr6:167370224 RNASET2 0.41 6.55 0.34 2.21e-10 Lung cancer; LUSC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.78 0.35 5.31e-11 Intelligence (multi-trait analysis); LUSC trans rs561341 0.700 rs8079471 chr17:30218317 A/G cg20587970 chr11:113659929 NA -0.7 -9.18 -0.45 4.53e-18 Hip circumference adjusted for BMI; LUSC cis rs1858037 0.806 rs12612780 chr2:65583101 A/G cg08085232 chr2:65598271 SPRED2 -0.38 -5.73 -0.3 2.18e-8 Rheumatoid arthritis; LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg01802117 chr1:53393560 SCP2 0.38 6.23 0.32 1.42e-9 Monocyte count; LUSC cis rs58785573 0.504 rs9522 chr4:38666972 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.55 8.39 0.42 1.41e-15 Lymphocyte percentage of white cells; LUSC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg00033643 chr7:134001901 SLC35B4 0.42 6.29 0.33 1.01e-9 Mean platelet volume; LUSC cis rs8027181 0.958 rs4776614 chr15:73082468 C/G cg25632853 chr15:73088954 NA 0.34 6.59 0.34 1.75e-10 Triglyceride levels; LUSC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Body mass index; LUSC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg10792982 chr14:105748885 BRF1 0.49 8.62 0.43 2.7e-16 Mean platelet volume;Platelet distribution width; LUSC trans rs1512268 0.672 rs6557705 chr8:23496546 A/G cg08659539 chr15:41098188 ZFYVE19;DNAJC17 -0.38 -5.99 -0.31 5.46e-9 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs4776059 1.000 rs2414166 chr15:52901977 C/T cg22715398 chr15:52968154 KIAA1370 -0.67 -9.86 -0.47 2.61e-20 Schizophrenia; LUSC cis rs4494114 1.000 rs2147914 chr1:39352271 G/T cg25970120 chr1:39325951 RRAGC -0.39 -5.99 -0.31 5.39e-9 Blood protein levels; LUSC cis rs4919694 1.000 rs75691516 chr10:104652045 C/T cg23093090 chr10:104574429 C10orf26 -0.45 -5.65 -0.3 3.37e-8 Arsenic metabolism; LUSC trans rs9467603 0.800 rs4236040 chr6:25761209 T/C cg06606381 chr12:133084897 FBRSL1 0.6 6.21 0.32 1.53e-9 Intelligence (multi-trait analysis); LUSC cis rs1185460 1.000 rs1614264 chr11:118942638 A/C cg01677386 chr11:118938358 VPS11 -0.44 -6.12 -0.32 2.65e-9 Coronary artery disease; LUSC cis rs7223966 1.000 rs2874121 chr17:61731024 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.68 0.34 9.97e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg17376030 chr22:41985996 PMM1 -0.47 -6.05 -0.31 3.85e-9 Vitiligo; LUSC cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg23158103 chr7:148848205 ZNF398 -0.45 -7.06 -0.36 9.42e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs734999 0.588 rs2764848 chr1:2530694 G/A cg18932078 chr1:2524107 MMEL1 -0.33 -7.23 -0.37 3.33e-12 Ulcerative colitis; LUSC cis rs4285028 0.747 rs9838301 chr3:121375144 G/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.92 -12.87 -0.58 4.62e-31 Multiple sclerosis; LUSC trans rs561341 0.663 rs72821936 chr17:30224068 C/G cg20587970 chr11:113659929 NA -0.64 -8.94 -0.44 2.68e-17 Hip circumference adjusted for BMI; LUSC trans rs7615952 0.576 rs4646763 chr3:125822129 G/A cg07211511 chr3:129823064 LOC729375 -0.75 -9.67 -0.47 1.2e-19 Blood pressure (smoking interaction); LUSC cis rs34779708 0.733 rs16935948 chr10:35549748 C/G cg03585969 chr10:35415529 CREM 0.49 6.75 0.35 6.45e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.2 0.49 1.98e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs8062405 0.789 rs1968752 chr16:28631585 G/T cg00204512 chr16:28754710 NA 0.34 6.14 0.32 2.4e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1949733 1.000 rs868105 chr4:8501030 G/T cg13073564 chr4:8508604 NA 0.48 8.96 0.44 2.37e-17 Response to antineoplastic agents; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 14.02 0.61 1.88e-35 Alzheimer's disease; LUSC trans rs62387962 0.764 rs3846685 chr5:157292978 T/A cg09066361 chr7:126890254 GRM8 0.49 6.42 0.33 4.71e-10 Platelet distribution width; LUSC cis rs7267979 0.586 rs1007708 chr20:25190959 C/T cg08601574 chr20:25228251 PYGB 0.45 6.84 0.35 3.81e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg15445000 chr17:37608096 MED1 -0.37 -6.46 -0.33 3.73e-10 Glomerular filtration rate (creatinine); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03027774 chr7:100304043 POP7 -0.48 -6.16 -0.32 2.04e-9 Hepatitis; LUSC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg21238619 chr17:78079768 GAA -0.3 -5.97 -0.31 6.09e-9 Yeast infection; LUSC cis rs273573 0.961 rs163854 chr11:30964632 G/T cg14844989 chr11:31128820 NA 0.38 6.03 0.31 4.37e-9 Total body bone mineral density; LUSC cis rs4363385 0.818 rs441229 chr1:153015059 A/C cg00922841 chr1:152955080 SPRR1A -0.45 -7.89 -0.4 4.44e-14 Inflammatory skin disease; LUSC cis rs8078723 0.690 rs56326707 chr17:38130139 C/T cg17467752 chr17:38218738 THRA 0.53 7.9 0.4 3.96e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.49 6.41 0.33 5.06e-10 Platelet count; LUSC trans rs4650994 0.544 rs4075631 chr1:178506594 C/A cg05059571 chr16:84539110 KIAA1609 -0.48 -9.14 -0.45 6.21e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg20887711 chr4:1340912 KIAA1530 0.55 8.73 0.43 1.28e-16 Longevity; LUSC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg22166914 chr1:53195759 ZYG11B 0.58 9.68 0.47 1.04e-19 Monocyte count; LUSC trans rs3733585 0.699 rs28613263 chr4:9964880 C/T cg26043149 chr18:55253948 FECH -0.44 -6.86 -0.35 3.45e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12681288 0.676 rs2701914 chr8:999935 C/T cg04851639 chr8:1020857 NA -0.37 -7.48 -0.38 6.58e-13 Schizophrenia; LUSC cis rs3931020 0.688 rs968358 chr1:75193989 G/T cg21535942 chr1:75199100 CRYZ;TYW3 0.46 5.77 0.3 1.8e-8 Resistin levels; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg10729496 chr3:10149963 C3orf24 0.56 7.62 0.38 2.65e-13 Alzheimer's disease; LUSC cis rs7267979 0.714 rs6115107 chr20:25237390 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.66 12.25 0.56 9.41e-29 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg25036284 chr2:26402008 FAM59B -0.68 -9.45 -0.46 6.03e-19 Gut microbiome composition (summer); LUSC cis rs709400 0.628 rs2010281 chr14:103862322 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.99 -0.31 5.41e-9 Body mass index; LUSC cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -8.88 -0.44 4.13e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs58688157 0.705 rs7943546 chr11:612148 T/C cg15790184 chr11:494944 RNH1 0.5 7.16 0.36 5.23e-12 Systemic lupus erythematosus; LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.96 0.36 1.85e-11 Platelet count; LUSC cis rs925255 0.817 rs12624279 chr2:28634790 G/A cg01273330 chr2:28605224 NA 0.44 7.14 0.36 5.76e-12 Inflammatory bowel disease;Crohn's disease; LUSC trans rs61931739 0.534 rs11052973 chr12:34029708 A/G cg26384229 chr12:38710491 ALG10B 0.72 11.31 0.53 2.59e-25 Morning vs. evening chronotype; LUSC cis rs11048434 0.761 rs1805765 chr12:9094548 A/G cg13575925 chr12:9217583 LOC144571 0.33 6.07 0.32 3.55e-9 Sjögren's syndrome; LUSC cis rs2795502 1.000 rs2795503 chr10:43347224 T/A cg27426351 chr10:43362370 NA -0.42 -5.87 -0.31 1.08e-8 Blood protein levels; LUSC cis rs1728785 0.901 rs698711 chr16:68561955 C/T cg02972257 chr16:68554789 NA -0.48 -6.19 -0.32 1.76e-9 Ulcerative colitis; LUSC cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg11645453 chr3:52864694 ITIH4 0.47 10.67 0.5 4.58e-23 Schizophrenia; LUSC cis rs6690583 0.623 rs12042845 chr1:85429801 A/G cg22153463 chr1:85462885 MCOLN2 0.64 6.3 0.33 9.63e-10 Serum sulfate level; LUSC cis rs7589342 0.839 rs11895235 chr2:106432355 C/G cg14210321 chr2:106509881 NCK2 -0.53 -7.92 -0.4 3.47e-14 Addiction; LUSC trans rs4843747 0.671 rs72818576 chr16:88111019 C/G cg26811252 chr16:29126840 RRN3P2 0.57 8.95 0.44 2.47e-17 Menopause (age at onset); LUSC cis rs7582180 0.591 rs2241810 chr2:101011877 T/C cg12002119 chr2:101014098 CHST10 0.36 6.02 0.31 4.56e-9 Intelligence (multi-trait analysis); LUSC cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg24011408 chr12:48396354 COL2A1 -0.39 -5.72 -0.3 2.34e-8 Glycated hemoglobin levels; LUSC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg03684893 chr10:554711 DIP2C -0.37 -6.68 -0.34 9.82e-11 Psychosis in Alzheimer's disease; LUSC trans rs116175374 0.793 rs6728152 chr2:31431651 A/G cg15543616 chr12:5019024 KCNA1 -0.73 -6.09 -0.32 3.13e-9 Endometriosis; LUSC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.42 -0.38 9.7e-13 Aortic root size; LUSC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -17.56 -0.69 2.3e-49 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11878476 chr22:39898238 SMCR7L -0.4 -6.08 -0.32 3.21e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg24692254 chr21:30365293 RNF160 -0.54 -7.86 -0.4 5.38e-14 Dental caries; LUSC cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.2 0.45 4.02e-18 Motion sickness; LUSC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23248424 chr5:179741104 GFPT2 0.53 8.48 0.42 7.63e-16 Height; LUSC cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg22508957 chr16:3507546 NAT15 0.43 6.68 0.34 1.02e-10 Body mass index (adult); LUSC cis rs965604 1.000 rs965604 chr15:78789223 G/A cg18825076 chr15:78729989 IREB2 -0.43 -6.82 -0.35 4.31e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2969070 0.674 rs2906146 chr7:2524939 A/G cg03277898 chr7:2518824 NA -0.3 -6.3 -0.33 9.6e-10 Diastolic blood pressure; LUSC cis rs7208859 0.623 rs7208088 chr17:29143667 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs634534 0.622 rs1308733 chr11:65720841 T/C cg17985854 chr11:65770987 BANF1;EIF1AD -0.49 -9.05 -0.44 1.18e-17 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs208520 0.690 rs6932475 chr6:66863155 G/A cg07460842 chr6:66804631 NA -1.14 -17.89 -0.7 1.12e-50 Exhaled nitric oxide output; LUSC cis rs4718428 1.000 rs868961 chr7:66437208 G/T cg18252515 chr7:66147081 NA -0.45 -6.83 -0.35 3.98e-11 Corneal structure; LUSC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg09877947 chr5:131593287 PDLIM4 -0.36 -5.76 -0.3 1.87e-8 Breast cancer;Mosquito bite size; LUSC cis rs3803170 0.513 rs4766574 chr12:111832372 C/T cg10833066 chr12:111807467 FAM109A 0.39 7.29 0.37 2.19e-12 Mean corpuscular hemoglobin; LUSC trans rs800082 0.698 rs800074 chr3:144347638 A/G cg24215973 chr2:240111563 HDAC4 -0.7 -10.35 -0.49 6.06e-22 Smoking behavior; LUSC cis rs907683 0.545 rs3755054 chr2:220280974 C/T cg15015639 chr2:220282977 DES 0.31 7.43 0.38 9e-13 Resting heart rate; LUSC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3806843 0.966 rs1030166 chr5:140185473 G/A cg19875535 chr5:140030758 IK 0.47 7.56 0.38 4.05e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg03806693 chr22:41940476 POLR3H 0.99 14.03 0.61 1.78e-35 Vitiligo; LUSC cis rs6961069 0.527 rs3211820 chr7:80278465 A/C cg04458919 chr7:80252533 CD36 0.39 6.82 0.35 4.16e-11 Platelet count; LUSC cis rs4796285 1.000 rs4796285 chr17:35181996 A/G cg10754668 chr17:35168702 NA -0.26 -6.13 -0.32 2.45e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg26513180 chr16:89883248 FANCA 0.61 5.79 0.3 1.61e-8 Skin colour saturation; LUSC cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 8.62 0.43 2.81e-16 Colorectal cancer; LUSC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg04800585 chr6:26043546 HIST1H2BB 0.44 6.29 0.33 9.96e-10 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg08807101 chr21:30365312 RNF160 -0.73 -12.82 -0.57 7.16e-31 Dental caries; LUSC cis rs4363385 0.626 rs6664183 chr1:153064002 A/G cg00922841 chr1:152955080 SPRR1A -0.33 -5.81 -0.3 1.44e-8 Inflammatory skin disease; LUSC cis rs58804349 0.581 rs12221397 chr10:43239833 A/G cg08461752 chr10:43522343 NA 0.53 5.83 0.3 1.34e-8 Pediatric bone mineral content (radius); LUSC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg05025164 chr4:1340916 KIAA1530 0.43 6.42 0.33 4.66e-10 Obesity-related traits; LUSC cis rs8060686 0.641 rs73598006 chr16:68074454 C/G cg04539111 chr16:67997858 SLC12A4 -0.42 -5.88 -0.31 1.02e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.91 -0.4 3.79e-14 Joint mobility (Beighton score); LUSC cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg06552810 chr11:31128660 NA -0.4 -7.12 -0.36 6.5e-12 Red blood cell count; LUSC cis rs7666738 0.546 rs10010088 chr4:98655945 C/T cg17366294 chr4:99064904 C4orf37 0.53 8.34 0.42 1.98e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs870825 0.616 rs28442259 chr4:185646962 T/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs1358748 0.522 rs4655675 chr1:67576075 C/T cg02640540 chr1:67518911 SLC35D1 0.64 6.17 0.32 2.03e-9 Tuberculosis; LUSC cis rs1775715 0.651 rs2808033 chr10:32194127 A/T cg26784012 chr10:32216390 ARHGAP12 0.47 7.91 0.4 3.91e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs72960926 0.744 rs3898077 chr6:74959122 G/A cg03266952 chr6:74778945 NA -0.85 -7.14 -0.36 5.86e-12 Metabolite levels (MHPG); LUSC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg23283495 chr1:209979779 IRF6 0.45 7.14 0.36 5.85e-12 Monobrow; LUSC cis rs2637266 1.000 rs7098790 chr10:78361077 T/A cg18941641 chr10:78392320 NA 0.4 7.45 0.38 7.84e-13 Pulmonary function; LUSC cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg08754478 chr10:133766260 PPP2R2D -0.62 -7.79 -0.39 8.39e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg06637938 chr14:75390232 RPS6KL1 -0.51 -8.02 -0.4 1.77e-14 Height; LUSC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 0.88 13.2 0.59 2.7e-32 Platelet count; LUSC cis rs829883 0.659 rs11109524 chr12:98939172 G/A cg25150519 chr12:98850993 NA -0.63 -8.71 -0.43 1.47e-16 Colorectal adenoma (advanced); LUSC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg20848291 chr7:100343083 ZAN -0.53 -6.6 -0.34 1.61e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs3916 0.794 rs10431384 chr12:121127347 C/T cg27246729 chr12:121163418 ACADS -0.47 -7.2 -0.37 3.95e-12 Urinary metabolites (H-NMR features); LUSC cis rs9611565 0.512 rs5758464 chr22:42171300 A/G cg03806693 chr22:41940476 POLR3H 0.99 12.43 0.56 2.08e-29 Vitiligo; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24517925 chr1:155715448 MSTO2P -0.45 -6.07 -0.32 3.57e-9 Hepatitis; LUSC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg15117754 chr3:10150083 C3orf24 0.45 5.72 0.3 2.4e-8 Alzheimer's disease; LUSC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg13319975 chr6:146136371 FBXO30 -0.66 -9.86 -0.47 2.74e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs6736093 0.966 rs13013340 chr2:112694988 C/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.9 -0.31 8.73e-9 Coronary artery disease; LUSC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg22903657 chr4:1355424 KIAA1530 -0.48 -8.13 -0.41 8.52e-15 Obesity-related traits; LUSC cis rs9309473 0.687 rs6748040 chr2:73609928 A/G cg20560298 chr2:73613845 ALMS1 0.55 8.24 0.41 3.93e-15 Metabolite levels; LUSC cis rs262150 0.566 rs262159 chr7:158772172 C/T cg19418458 chr7:158789849 NA 0.41 5.67 0.3 3.02e-8 Facial morphology (factor 20); LUSC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.14e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg26566898 chr11:117069891 TAGLN 0.37 7.22 0.37 3.49e-12 Blood protein levels; LUSC cis rs1891275 0.515 rs7911755 chr10:93489817 G/A cg07889827 chr10:93443413 NA -0.41 -9.4 -0.46 8.94e-19 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg22467129 chr15:76604101 ETFA -0.44 -7.04 -0.36 1.13e-11 Blood metabolite levels; LUSC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.69 -10.82 -0.51 1.38e-23 Monocyte percentage of white cells; LUSC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg03709012 chr19:19516395 GATAD2A 0.83 14.07 0.61 1.24e-35 Tonsillectomy; LUSC cis rs73198271 0.515 rs78922347 chr8:8627916 G/C cg01851573 chr8:8652454 MFHAS1 0.63 7.36 0.37 1.45e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs561341 1.000 rs497479 chr17:30328605 C/T cg27661571 chr11:113659931 NA -0.7 -8.16 -0.41 6.68e-15 Hip circumference adjusted for BMI; LUSC cis rs2806561 0.704 rs856510 chr1:23524407 A/C cg19743168 chr1:23544995 NA 0.46 9.21 0.45 3.75e-18 Height; LUSC cis rs11677416 1.000 rs1800587 chr2:113542960 C/T cg27083787 chr2:113543245 IL1A 0.45 7.17 0.37 4.92e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs10843647 0.967 rs973485 chr12:30326144 T/A cg12718339 chr12:29936407 TMTC1 -0.35 -5.84 -0.3 1.27e-8 Glucose homeostasis traits; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg08088566 chr11:430123 ANO9 0.64 7.2 0.37 4.01e-12 Body mass index; LUSC cis rs367615 0.704 rs72804385 chr5:108848143 T/C cg17395555 chr5:108820864 NA 0.6 11.27 0.52 3.59e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs9467773 0.534 rs34453863 chr6:26628005 T/C cg09904177 chr6:26538194 HMGN4 0.63 10.57 0.5 1.02e-22 Intelligence (multi-trait analysis); LUSC cis rs9325144 0.625 rs12227353 chr12:38734542 C/T cg13010199 chr12:38710504 ALG10B -0.48 -7.35 -0.37 1.5e-12 Morning vs. evening chronotype; LUSC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.47 5.97 0.31 6.23e-9 Schizophrenia; LUSC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg03709012 chr19:19516395 GATAD2A 0.84 14.26 0.62 2.26e-36 Tonsillectomy; LUSC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg06637938 chr14:75390232 RPS6KL1 0.54 8.69 0.43 1.63e-16 Height; LUSC cis rs2854160 0.581 rs2727319 chr17:61960215 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.01 19.95 0.74 7.16e-59 Height; LUSC cis rs7178572 0.633 rs4886876 chr15:77838491 C/T cg22256960 chr15:77711686 NA -0.46 -6.85 -0.35 3.6e-11 Type 2 diabetes; LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg18765753 chr7:1198926 ZFAND2A -0.39 -7.35 -0.37 1.5e-12 Longevity;Endometriosis; LUSC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg05552183 chr6:42928497 GNMT 0.49 8.17 0.41 6.42e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg15744005 chr10:104629667 AS3MT -0.34 -6.92 -0.35 2.31e-11 Arsenic metabolism; LUSC cis rs11168618 0.967 rs1895996 chr12:48955571 A/C cg24011408 chr12:48396354 COL2A1 0.41 6.35 0.33 6.89e-10 Adiponectin levels; LUSC cis rs11644601 1 rs11644601 chr16:15172118 T/C cg27102117 chr16:15229624 NA 0.37 5.66 0.3 3.33e-8 Metabolite levels (lipid measures); LUSC cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg09904177 chr6:26538194 HMGN4 -0.52 -5.8 -0.3 1.51e-8 Intelligence (multi-trait analysis); LUSC cis rs921968 0.541 rs2556391 chr2:219556346 T/C cg02176678 chr2:219576539 TTLL4 -0.73 -14.14 -0.61 6.67e-36 Mean corpuscular hemoglobin concentration; LUSC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg14582100 chr15:45693742 SPATA5L1 0.59 10.83 0.51 1.25e-23 Homoarginine levels; LUSC cis rs6951245 0.872 rs57068908 chr7:1060084 A/C cg24642844 chr7:1081250 C7orf50 -0.71 -9.69 -0.47 1.01e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg21672276 chr3:44754072 ZNF502 -0.37 -5.8 -0.3 1.56e-8 Depressive symptoms; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15864354 chr12:120966977 COQ5 -0.41 -6.13 -0.32 2.41e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.64 -0.43 2.42e-16 Schizophrenia; LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg08470875 chr2:26401718 FAM59B 0.75 10.02 0.48 7.77e-21 Mean corpuscular hemoglobin; LUSC cis rs131777 0.545 rs140514 chr22:51018579 A/G cg00083937 chr22:51039805 MAPK8IP2 0.52 9.02 0.44 1.48e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.24 0.49 1.34e-21 Bladder cancer; LUSC trans rs11098499 0.954 rs10017371 chr4:120293776 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.27 0.32 1.13e-9 Corneal astigmatism; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg23034840 chr1:205782522 SLC41A1 0.55 7.51 0.38 5.52e-13 Menarche (age at onset); LUSC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg18876405 chr7:65276391 NA -0.7 -12.66 -0.57 2.88e-30 Aortic root size; LUSC cis rs6504340 0.739 rs66459980 chr17:46672716 C/T cg09704116 chr17:46666958 LOC404266 -0.4 -6.2 -0.32 1.71e-9 Primary tooth development (number of teeth); LUSC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg04234412 chr22:24373322 LOC391322 -0.92 -16.31 -0.67 2.03e-44 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC cis rs17401966 0.558 rs4846218 chr1:10452040 G/T cg17425144 chr1:10567563 PEX14 -0.33 -6.04 -0.31 4.2e-9 Hepatocellular carcinoma; LUSC cis rs9341808 0.538 rs667097 chr6:80978943 G/A cg08355045 chr6:80787529 NA -0.4 -6.84 -0.35 3.71e-11 Sitting height ratio; LUSC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg15790184 chr11:494944 RNH1 0.58 6.33 0.33 7.7e-10 Body mass index; LUSC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg24110177 chr3:50126178 RBM5 0.63 11.14 0.52 1.05e-24 Body mass index; LUSC cis rs6539267 0.847 rs12831519 chr12:106682917 A/G cg00173435 chr12:106696525 TCP11L2 0.58 7.7 0.39 1.6e-13 Tourette syndrome; LUSC trans rs61931739 0.929 rs10844748 chr12:34092930 G/T cg26384229 chr12:38710491 ALG10B -0.58 -9.4 -0.46 9.08e-19 Morning vs. evening chronotype; LUSC trans rs57221529 0.766 rs12519469 chr5:581772 A/G cg25482853 chr8:67687455 SGK3 1.14 16.0 0.66 3.65e-43 Lung disease severity in cystic fibrosis; LUSC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg02423579 chr7:2872169 GNA12 -0.44 -6.42 -0.33 4.76e-10 Height; LUSC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7607980 1.000 rs7607980 chr2:165551201 A/G cg21604450 chr1:66998563 SGIP1 0.52 6.23 0.32 1.41e-9 Fasting blood insulin (BMI interaction);Fasting blood insulin;Type 2 diabetes; LUSC cis rs804280 1.000 rs804281 chr8:11611865 A/G cg12395012 chr8:11607386 GATA4 -0.33 -5.77 -0.3 1.83e-8 Myopia (pathological); LUSC cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg20019365 chr2:219134978 PNKD;AAMP 0.41 6.29 0.33 9.85e-10 Colorectal cancer; LUSC cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.56e-8 Breast cancer; LUSC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg10755058 chr3:40428713 ENTPD3 0.38 6.27 0.32 1.12e-9 Renal cell carcinoma; LUSC cis rs7954584 0.505 rs11043278 chr12:122412145 C/T cg13699009 chr12:122356056 WDR66 0.48 7.22 0.37 3.64e-12 Mean corpuscular volume; LUSC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg14895029 chr7:2775587 GNA12 -0.37 -6.05 -0.31 3.87e-9 Height; LUSC cis rs367943 0.712 rs6594707 chr5:112700503 C/T cg12552261 chr5:112820674 MCC 0.39 6.47 0.33 3.44e-10 Type 2 diabetes; LUSC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.67 0.39 1.87e-13 Bipolar disorder; LUSC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg13770153 chr20:60521292 NA -0.67 -9.58 -0.46 2.31e-19 Body mass index; LUSC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg05347473 chr6:146136440 FBXO30 0.53 8.77 0.43 9.28e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg06873352 chr17:61820015 STRADA 0.7 12.21 0.56 1.32e-28 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg21782813 chr7:2030301 MAD1L1 0.43 7.08 0.36 8.59e-12 Bipolar disorder and schizophrenia; LUSC cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.76 8.88 0.44 4.19e-17 Schizophrenia; LUSC cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg14789911 chr21:47582049 C21orf56 0.41 6.42 0.33 4.79e-10 Testicular germ cell tumor; LUSC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg22535103 chr8:58192502 C8orf71 -0.76 -9.6 -0.47 1.96e-19 Developmental language disorder (linguistic errors); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22571926 chr5:56112222 MAP3K1 0.41 6.08 0.32 3.25e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg00071950 chr4:10020882 SLC2A9 0.61 10.16 0.49 2.63e-21 Bone mineral density; LUSC cis rs500891 0.533 rs10943934 chr6:84181508 C/G cg08257003 chr6:84140564 ME1 0.33 8.1 0.41 1.05e-14 Platelet-derived growth factor BB levels; LUSC cis rs7582180 0.629 rs11678148 chr2:100966950 A/T cg14675211 chr2:100938903 LONRF2 0.36 5.68 0.3 2.94e-8 Intelligence (multi-trait analysis); LUSC cis rs7582720 1.000 rs72926779 chr2:203805929 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7149337 0.836 rs35345236 chr14:51671817 T/C cg23942311 chr14:51606299 NA 0.48 10.53 0.5 1.39e-22 Cancer; LUSC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg18681998 chr4:17616180 MED28 0.77 13.59 0.6 8.66e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.75 10.72 0.51 3.12e-23 Cognitive test performance; LUSC trans rs877282 0.898 rs11253356 chr10:768604 G/A cg13042288 chr15:90349979 ANPEP -0.42 -6.12 -0.32 2.66e-9 Uric acid levels; LUSC cis rs727505 1.000 rs28702851 chr7:124442991 G/A cg23710748 chr7:124431027 NA -0.43 -7.66 -0.39 2.02e-13 Lewy body disease; LUSC cis rs12421382 0.659 rs35527696 chr11:109379944 T/A cg16359550 chr11:109292809 C11orf87 0.35 6.05 0.31 3.96e-9 Schizophrenia; LUSC cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg03146154 chr1:46216737 IPP -0.51 -7.68 -0.39 1.81e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13315871 0.929 rs13082278 chr3:58318224 A/G cg12435725 chr3:58293450 RPP14 -0.71 -7.18 -0.37 4.5e-12 Cholesterol, total; LUSC cis rs936229 0.906 rs9210 chr15:75128501 T/C cg14664628 chr15:75095509 CSK -0.94 -14.78 -0.63 2.11e-38 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg11062466 chr8:58055876 NA -0.73 -9.43 -0.46 6.93e-19 Developmental language disorder (linguistic errors); LUSC cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.62 -6.63 -0.34 1.33e-10 Birth weight; LUSC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg17294928 chr15:75287854 SCAMP5 0.41 5.99 0.31 5.56e-9 Breast cancer; LUSC cis rs10876993 0.928 rs1678530 chr12:58054076 A/C cg18357645 chr12:58087776 OS9 0.52 7.72 0.39 1.32e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs9329221 0.686 rs35406700 chr8:10244593 A/G cg27411982 chr8:10470053 RP1L1 0.44 6.58 0.34 1.85e-10 Neuroticism; LUSC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg01652190 chr22:50026171 C22orf34 -0.3 -6.32 -0.33 8.5e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6700896 0.897 rs11208696 chr1:66121781 T/G cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs7939886 0.920 rs7934132 chr11:55942463 T/A cg03929089 chr4:120376271 NA 0.8 6.07 0.32 3.54e-9 Myopia (pathological); LUSC cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg12698349 chr2:225449008 CUL3 -0.76 -9.32 -0.45 1.64e-18 IgE levels in asthmatics (D.p. specific); LUSC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03934478 chr11:495069 RNH1 0.84 9.62 0.47 1.75e-19 Body mass index; LUSC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg00343986 chr7:65444356 GUSB -0.42 -6.44 -0.33 4.24e-10 Aortic root size; LUSC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC trans rs11992162 0.636 rs4841646 chr8:11798707 C/G cg15556689 chr8:8085844 FLJ10661 0.48 6.77 0.35 5.73e-11 Monocyte count; LUSC cis rs637571 0.544 rs55704213 chr11:65730002 C/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.46 6.68 0.34 1.02e-10 Eosinophil percentage of white cells; LUSC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg13319975 chr6:146136371 FBXO30 -0.51 -7.72 -0.39 1.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg01097406 chr16:89675127 NA 0.3 5.95 0.31 6.82e-9 Hemoglobin concentration; LUSC cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg02403541 chr12:121454288 C12orf43 0.74 11.86 0.54 2.6e-27 N-glycan levels; LUSC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg22800045 chr5:56110881 MAP3K1 0.75 9.72 0.47 7.76e-20 Initial pursuit acceleration; LUSC cis rs1595825 0.945 rs1850634 chr2:198827896 T/C cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 6.08e-9 Ulcerative colitis; LUSC cis rs9814567 1.000 rs6804770 chr3:134230234 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.74 -0.6 2.34e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10875746 0.903 rs58952582 chr12:48458448 T/G cg13454099 chr12:49076203 C12orf41 -0.5 -5.73 -0.3 2.22e-8 Longevity (90 years and older); LUSC cis rs6960043 0.738 rs10950548 chr7:15057728 G/A cg19272540 chr7:15055459 NA 0.35 8.5 0.42 6.52e-16 Type 2 diabetes; LUSC cis rs62400317 0.859 rs12201899 chr6:45298204 C/A cg20913747 chr6:44695427 NA -0.48 -7.77 -0.39 9.74e-14 Total body bone mineral density; LUSC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg00033643 chr7:134001901 SLC35B4 0.43 6.56 0.34 2.09e-10 Mean platelet volume; LUSC cis rs7923609 0.967 rs6479896 chr10:65126832 T/C cg01631684 chr10:65280961 REEP3 -0.39 -6.08 -0.32 3.24e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs2739330 0.760 rs1007888 chr22:24241101 C/T cg06437703 chr8:37914619 EIF4EBP1 -0.6 -10.09 -0.48 4.57e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg25456477 chr12:86230367 RASSF9 0.44 7.88 0.4 4.75e-14 Major depressive disorder; LUSC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg06550200 chr5:1325588 CLPTM1L 0.61 10.45 0.5 2.59e-22 Lung cancer; LUSC cis rs11098499 0.954 rs10017371 chr4:120293776 A/G cg24375607 chr4:120327624 NA 0.77 11.0 0.52 3.29e-24 Corneal astigmatism; LUSC cis rs9473147 0.516 rs9357546 chr6:47549495 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.74 0.3 2.1e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs2235649 0.833 rs9925460 chr16:1849943 C/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.42 -5.82 -0.3 1.39e-8 Blood metabolite levels; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg13395646 chr4:1353034 KIAA1530 -0.66 -11.22 -0.52 5.13e-25 Longevity; LUSC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg12463550 chr7:65579703 CRCP -0.55 -8.26 -0.41 3.47e-15 Aortic root size; LUSC trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21659725 chr3:3221576 CRBN -0.62 -9.09 -0.45 9.04e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs6430585 0.583 rs11886852 chr2:136589379 G/A cg07169764 chr2:136633963 MCM6 1.06 15.68 0.65 6.59e-42 Corneal structure; LUSC cis rs6066835 1.000 rs3817991 chr20:47296365 G/C cg18078177 chr20:47281410 PREX1 0.77 5.94 0.31 7.31e-9 Multiple myeloma; LUSC cis rs12220238 0.730 rs4746177 chr10:75913033 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.21 0.37 3.81e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs11018904 0.906 rs35286339 chr11:89965679 A/G cg26834418 chr11:89957033 CHORDC1 -0.5 -6.34 -0.33 7.54e-10 Intelligence (multi-trait analysis); LUSC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg04455712 chr21:45112962 RRP1B 0.44 8.34 0.42 1.98e-15 Mean corpuscular volume; LUSC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg05347473 chr6:146136440 FBXO30 -0.66 -11.7 -0.54 9.51e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg06740227 chr12:86229804 RASSF9 0.41 6.3 0.33 9.5e-10 Major depressive disorder; LUSC cis rs11098499 0.909 rs1809406 chr4:120377122 G/A cg24375607 chr4:120327624 NA 0.77 11.46 0.53 7.47e-26 Corneal astigmatism; LUSC cis rs6121246 0.909 rs6058460 chr20:30363071 G/A cg13852791 chr20:30311386 BCL2L1 0.89 11.91 0.55 1.75e-27 Mean corpuscular hemoglobin; LUSC trans rs11250098 0.503 rs13270870 chr8:10770782 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -8.03 -0.4 1.68e-14 Morning vs. evening chronotype; LUSC cis rs4700695 0.841 rs251608 chr5:65247893 C/T cg21114390 chr5:65439923 SFRS12 0.5 5.93 0.31 7.61e-9 Facial morphology (factor 19); LUSC cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg04586622 chr2:25135609 ADCY3 0.42 8.98 0.44 1.97e-17 Body mass index in non-asthmatics; LUSC cis rs1559088 0.744 rs12462426 chr19:33536683 A/C cg17764715 chr19:33622953 WDR88 0.48 6.36 0.33 6.56e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9815354 1.000 rs9846634 chr3:41894049 G/A cg03022575 chr3:42003672 ULK4 0.63 6.84 0.35 3.85e-11 Pulse pressure;Diastolic blood pressure; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg18440188 chr14:50999316 MAP4K5;ATL1 0.39 5.97 0.31 6.05e-9 Mosquito bite size; LUSC cis rs2463822 0.858 rs2513037 chr11:62084822 A/T cg06239285 chr11:62104954 ASRGL1 -0.95 -10.53 -0.5 1.45e-22 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs909341 0.710 rs6089953 chr20:62291008 C/T cg16989086 chr20:62203971 PRIC285 0.52 7.21 0.37 3.8e-12 Atopic dermatitis; LUSC trans rs72674100 1.000 rs10002900 chr4:97974161 T/A cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.14 0.32 2.34e-9 Rheumatoid arthritis; LUSC cis rs2404602 0.692 rs35557205 chr15:77130711 T/G cg23625390 chr15:77176239 SCAPER 0.48 7.12 0.36 6.86e-12 Blood metabolite levels; LUSC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.16 -0.32 2.05e-9 Major depressive disorder; LUSC cis rs4731207 1.000 rs4731207 chr7:124396645 G/A cg14311320 chr7:124405732 GPR37 0.31 6.02 0.31 4.49e-9 Cutaneous malignant melanoma; LUSC cis rs559928 0.548 rs11231713 chr11:63931849 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.25 0.37 2.93e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg12927641 chr6:109611667 NA -0.35 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs34779708 0.966 rs10827492 chr10:35429825 A/G cg03585969 chr10:35415529 CREM -0.65 -9.59 -0.46 2.12e-19 Inflammatory bowel disease;Crohn's disease; LUSC trans rs7618501 0.633 rs13060128 chr3:50025028 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.95 0.44 2.54e-17 Intelligence (multi-trait analysis); LUSC cis rs796364 0.806 rs74706215 chr2:200941367 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -8.2 -0.41 5.32e-15 Schizophrenia; LUSC cis rs826838 0.616 rs10880751 chr12:38627485 C/T cg26384229 chr12:38710491 ALG10B 0.57 8.51 0.42 6.11e-16 Heart rate; LUSC cis rs12545109 0.800 rs1595940 chr8:57398309 T/C cg09654669 chr8:57350985 NA -0.52 -6.89 -0.35 2.85e-11 Obesity-related traits; LUSC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg18404041 chr3:52824283 ITIH1 0.63 11.73 0.54 7.41e-27 Bipolar disorder; LUSC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.24 -0.32 1.34e-9 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg03146154 chr1:46216737 IPP -0.56 -8.22 -0.41 4.54e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg08999081 chr20:33150536 PIGU 0.37 6.82 0.35 4.34e-11 Height; LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.05 -0.31 3.93e-9 Platelet count; LUSC cis rs1577917 0.837 rs10944157 chr6:86577199 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.21 -0.41 4.85e-15 Response to antipsychotic treatment; LUSC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs61931739 0.929 rs3912551 chr12:34076696 C/T cg06521331 chr12:34319734 NA 0.37 6.29 0.33 1e-9 Morning vs. evening chronotype; LUSC cis rs950169 0.650 rs12902052 chr15:85125838 A/T cg11189052 chr15:85197271 WDR73 0.48 5.86 0.31 1.14e-8 Schizophrenia; LUSC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg12257692 chr3:49977190 RBM6 -0.24 -6.57 -0.34 1.97e-10 Intelligence (multi-trait analysis); LUSC cis rs73416724 1.000 rs111408004 chr6:43326139 T/A cg26312998 chr6:43337775 ZNF318 0.57 6.66 0.34 1.16e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg07701084 chr6:150067640 NUP43 0.46 6.89 0.35 2.73e-11 Testicular germ cell tumor; LUSC cis rs6060717 0.536 rs2425104 chr20:34312346 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.27 -0.32 1.14e-9 Hip circumference adjusted for BMI; LUSC cis rs751728 0.664 rs6929696 chr6:33759290 C/T cg25922239 chr6:33757077 LEMD2 -0.41 -6.27 -0.32 1.11e-9 Crohn's disease; LUSC cis rs523522 0.673 rs643372 chr12:121022640 C/G cg12219531 chr12:120966889 COQ5 0.66 9.0 0.44 1.71e-17 High light scatter reticulocyte count; LUSC cis rs4629180 0.586 rs10172555 chr2:102126837 C/T cg04415270 chr2:102091202 RFX8 -0.44 -7.74 -0.39 1.16e-13 Chronic rhinosinusitis with nasal polyps; LUSC cis rs8031584 1.000 rs35607976 chr15:31277788 T/C cg08704250 chr15:31115839 NA -0.55 -8.05 -0.4 1.43e-14 Huntington's disease progression; LUSC cis rs2408955 0.501 rs8716 chr12:48539482 T/G cg24011408 chr12:48396354 COL2A1 0.39 5.79 0.3 1.59e-8 Glycated hemoglobin levels; LUSC cis rs1007190 0.881 rs9909048 chr17:42973517 G/C cg15406952 chr17:42872593 NA 0.56 5.76 0.3 1.88e-8 DNA methylation (variation); LUSC cis rs4851254 0.961 rs13028981 chr2:100795783 C/T cg07810366 chr2:100720526 AFF3 -0.36 -5.72 -0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC trans rs11039798 0.764 rs11039771 chr11:48513273 C/T cg15704280 chr7:45808275 SEPT13 0.71 6.65 0.34 1.21e-10 Axial length; LUSC cis rs921968 0.643 rs497983 chr2:219415189 A/G cg02176678 chr2:219576539 TTLL4 0.61 11.01 0.52 2.96e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg13012494 chr21:47604986 C21orf56 0.53 8.1 0.41 1.05e-14 Testicular germ cell tumor; LUSC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg25174290 chr11:3078921 CARS 0.61 9.89 0.48 2.17e-20 Longevity; LUSC cis rs12900413 0.564 rs8035800 chr15:90314790 T/C cg24249390 chr15:90295951 MESP1 -0.37 -5.75 -0.3 2.05e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9549260 0.664 rs9532575 chr13:41225361 G/C cg21288729 chr13:41239152 FOXO1 0.65 10.04 0.48 6.48e-21 Red blood cell count; LUSC cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg00049323 chr5:472564 LOC25845 0.48 7.62 0.38 2.73e-13 Cystic fibrosis severity; LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg13395646 chr4:1353034 KIAA1530 0.6 9.19 0.45 4.14e-18 Obesity-related traits; LUSC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11644478 chr21:40555479 PSMG1 0.95 19.4 0.73 1.07e-56 Cognitive function; LUSC cis rs2282032 0.550 rs58363992 chr14:90766361 T/C cg14092571 chr14:90743983 NA 0.47 7.89 0.4 4.38e-14 Longevity; LUSC cis rs10733682 0.715 rs3814119 chr9:129462901 A/G cg00232160 chr9:129468157 NA 0.36 6.38 0.33 5.97e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6088813 0.961 rs6060369 chr20:33907161 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.37 -5.8 -0.3 1.51e-8 Height; LUSC cis rs2692947 0.644 rs1168968 chr2:96825363 C/T cg22654517 chr2:96458247 NA 0.33 6.03 0.31 4.38e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9359856 0.510 rs74437492 chr6:90338728 A/G cg13799429 chr6:90582589 CASP8AP2 -0.92 -10.86 -0.51 9.93e-24 Bipolar disorder; LUSC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg00701064 chr4:6280414 WFS1 0.53 13.22 0.59 2.16e-32 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs877282 0.945 rs11253390 chr10:788678 A/G cg17470449 chr10:769945 NA 0.51 7.01 0.36 1.33e-11 Uric acid levels; LUSC cis rs7818345 0.967 rs11786847 chr8:19277200 T/C cg11303988 chr8:19266685 CSGALNACT1 0.38 7.31 0.37 1.95e-12 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1185460 0.904 rs1003081 chr11:118913993 A/G cg01677386 chr11:118938358 VPS11 0.45 6.29 0.33 9.67e-10 Coronary artery disease; LUSC cis rs796825 0.530 rs4146300 chr3:120000196 A/G cg21790991 chr3:120137480 FSTL1 -0.38 -6.88 -0.35 2.92e-11 HIV-1 susceptibility; LUSC cis rs2839186 0.843 rs17182671 chr21:47696238 T/C cg11766577 chr21:47581405 C21orf56 -0.43 -6.41 -0.33 4.9e-10 Testicular germ cell tumor; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3862030 0.720 rs11593583 chr10:104228149 A/G cg05855489 chr10:104503620 C10orf26 -0.45 -6.82 -0.35 4.2e-11 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs1524927 0.966 rs2140742 chr7:96364115 G/A cg03808172 chr7:96339361 SHFM1 0.43 6.52 0.34 2.63e-10 Total body bone mineral density; LUSC cis rs1023500 0.596 rs5751204 chr22:42433801 C/T cg04733989 chr22:42467013 NAGA 0.62 9.67 0.47 1.12e-19 Schizophrenia; LUSC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -8.57 -0.42 3.77e-16 Personality dimensions; LUSC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.65 5.67 0.3 3.04e-8 LDL cholesterol;Cholesterol, total; LUSC trans rs10506458 1.000 rs12425655 chr12:63434463 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.15 -15.97 -0.66 4.67e-43 Hemostatic factors and hematological phenotypes; LUSC cis rs1577917 1.000 rs12205336 chr6:86722367 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.68e-17 Response to antipsychotic treatment; LUSC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6430585 0.702 rs3213890 chr2:136552188 G/A cg07169764 chr2:136633963 MCM6 1.18 17.58 0.69 2e-49 Corneal structure; LUSC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg18200150 chr17:30822561 MYO1D 0.49 9.4 0.46 8.83e-19 Schizophrenia; LUSC cis rs7772486 0.727 rs10223508 chr6:146285205 C/T cg05347473 chr6:146136440 FBXO30 -0.57 -9.84 -0.47 3.22e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg01579765 chr21:45077557 HSF2BP 0.53 11.1 0.52 1.37e-24 Mean corpuscular volume; LUSC trans rs4788815 1.000 rs4788815 chr16:71634811 A/T cg19812283 chr5:173021074 NA -0.35 -6.2 -0.32 1.68e-9 Metabolite levels; LUSC cis rs11024102 0.830 rs11024110 chr11:17028390 T/A cg15378786 chr11:17036137 PLEKHA7 0.44 5.93 0.31 7.44e-9 Glaucoma (primary angle closure); LUSC cis rs9814567 0.712 rs9838621 chr3:134332319 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.62 -0.57 4.01e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg07424592 chr7:64974309 NA 0.69 5.99 0.31 5.45e-9 Diabetic kidney disease; LUSC cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.34 -5.76 -0.3 1.94e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs34779708 0.966 rs12769575 chr10:35435927 A/T cg03585969 chr10:35415529 CREM 0.6 8.79 0.43 8.31e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7903847 0.642 rs7074511 chr10:99140177 G/A cg20016023 chr10:99160130 RRP12 -0.33 -8.18 -0.41 6.15e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs2629540 0.781 rs11245362 chr10:126458649 T/C cg08799069 chr10:126477246 METTL10 -0.68 -10.11 -0.48 3.87e-21 Cocaine dependence; LUSC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg13902645 chr11:5959945 NA -0.57 -8.11 -0.41 1.01e-14 DNA methylation (variation); LUSC cis rs7843479 1.000 rs66824050 chr8:21815425 T/G cg17168535 chr8:21777572 XPO7 0.65 10.0 0.48 8.94e-21 Mean corpuscular volume; LUSC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg13206674 chr6:150067644 NUP43 0.57 9.07 0.44 1.06e-17 Lung cancer; LUSC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg16339924 chr4:17578868 LAP3 0.55 8.38 0.42 1.46e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg03709012 chr19:19516395 GATAD2A 0.85 14.66 0.63 6.35e-38 Tonsillectomy; LUSC trans rs2687481 0.718 rs1419500 chr7:125932208 A/G cg07319014 chr16:89777268 C16orf7 -0.47 -6.55 -0.34 2.16e-10 Hearing function; LUSC cis rs7568458 0.709 rs2043675 chr2:85769975 C/T cg02493740 chr2:85810744 VAMP5 0.52 9.16 0.45 5.48e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.29 -5.71 -0.3 2.51e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 14.26 0.62 2.24e-36 Platelet count; LUSC trans rs17086172 0.630 rs1432075 chr18:70273078 C/T cg02919422 chr8:55370544 SOX17 -0.61 -6.29 -0.33 1.02e-9 Airflow obstruction; LUSC cis rs9326248 0.559 rs609177 chr11:116770517 A/G cg11861562 chr11:117069780 TAGLN 0.35 6.74 0.35 6.81e-11 Blood protein levels; LUSC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg03709012 chr19:19516395 GATAD2A 0.75 11.57 0.53 2.96e-26 Tonsillectomy; LUSC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg06640241 chr16:89574553 SPG7 0.86 15.69 0.65 6.11e-42 Multiple myeloma (IgH translocation); LUSC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.61 -9.06 -0.44 1.12e-17 Alzheimer's disease; LUSC trans rs3808502 0.527 rs2736374 chr8:11113828 A/G cg15556689 chr8:8085844 FLJ10661 -0.46 -6.74 -0.35 6.81e-11 Neuroticism; LUSC cis rs782590 0.967 rs10496050 chr2:55806313 C/T cg18811423 chr2:55921094 PNPT1 0.82 14.19 0.61 4.4e-36 Metabolic syndrome; LUSC cis rs11997175 0.583 rs12680755 chr8:33815282 G/A ch.8.33884649F chr8:33765107 NA 0.45 6.49 0.33 3.06e-10 Body mass index; LUSC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg11584989 chr19:19387371 SF4 0.5 6.07 0.32 3.47e-9 Bipolar disorder; LUSC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg27165867 chr14:105738592 BRF1 -0.51 -7.54 -0.38 4.43e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs698813 0.604 rs11676798 chr2:44479982 G/C cg00619915 chr2:44497795 NA -0.51 -7.31 -0.37 1.98e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs9788721 0.836 rs72738732 chr15:78752188 C/G cg18825076 chr15:78729989 IREB2 -0.64 -10.39 -0.49 4.35e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg02825653 chr17:7383046 ZBTB4 0.42 6.27 0.32 1.12e-9 N-glycan levels; LUSC cis rs1577917 1.000 rs12205548 chr6:86759770 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.46 -0.42 8.72e-16 Response to antipsychotic treatment; LUSC cis rs4911259 0.552 rs11700082 chr20:31460244 A/G cg13636640 chr20:31349939 DNMT3B -0.81 -15.5 -0.65 3.37e-41 Inflammatory bowel disease; LUSC cis rs7246967 0.611 rs7246424 chr19:22882185 A/G cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs61931739 0.782 rs3903201 chr12:34248275 G/A cg06521331 chr12:34319734 NA -0.4 -6.81 -0.35 4.54e-11 Morning vs. evening chronotype; LUSC cis rs12908161 1.000 rs62021219 chr15:85256159 C/T cg11189052 chr15:85197271 WDR73 0.49 5.98 0.31 5.78e-9 Schizophrenia; LUSC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg03351412 chr1:154909251 PMVK 0.47 7.24 0.37 3.19e-12 Prostate cancer; LUSC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg02353165 chr6:42928485 GNMT 0.65 10.94 0.51 5.38e-24 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4268898 0.760 rs4665675 chr2:24468132 C/T cg06627628 chr2:24431161 ITSN2 -0.58 -8.4 -0.42 1.28e-15 Asthma; LUSC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.69 11.58 0.54 2.69e-26 Menarche (age at onset); LUSC cis rs6456156 0.586 rs12213683 chr6:167460718 G/A cg25258033 chr6:167368657 RNASET2 0.36 5.66 0.3 3.2e-8 Primary biliary cholangitis; LUSC cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg03146154 chr1:46216737 IPP 0.5 7.51 0.38 5.56e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs67478160 0.634 rs2368558 chr14:104230518 A/G cg01849466 chr14:104193079 ZFYVE21 -0.61 -10.38 -0.49 4.57e-22 Schizophrenia; LUSC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg10729496 chr3:10149963 C3orf24 0.54 7.36 0.37 1.4e-12 Alzheimer's disease; LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs2404602 0.647 rs12904149 chr15:77043652 A/C cg23625390 chr15:77176239 SCAPER -0.66 -10.01 -0.48 8.54e-21 Blood metabolite levels; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6674176 0.542 rs803679 chr1:44349405 G/A cg15962314 chr1:44399869 ARTN 0.27 6.1 0.32 2.89e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.47 0.38 7.29e-13 Motion sickness; LUSC cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg13736514 chr6:26305472 NA -0.46 -9.26 -0.45 2.64e-18 Educational attainment; LUSC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg16235748 chr6:149772707 ZC3H12D 0.28 5.69 0.3 2.72e-8 Dupuytren's disease; LUSC cis rs79387448 0.810 rs75218113 chr2:103239356 C/G cg09003973 chr2:102972529 NA 0.85 8.02 0.4 1.81e-14 Gut microbiota (bacterial taxa); LUSC trans rs11098499 0.738 rs10026493 chr4:120384194 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.14e-9 Corneal astigmatism; LUSC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg03036452 chr22:46663545 TTC38 0.59 5.88 0.31 1e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg00101154 chr16:420108 MRPL28 -0.39 -5.75 -0.3 2.01e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg08999081 chr20:33150536 PIGU 0.52 10.43 0.5 3.13e-22 Glomerular filtration rate (creatinine); LUSC cis rs11864453 0.826 rs2072142 chr16:72132713 C/T cg01557791 chr16:72042693 DHODH -0.51 -7.33 -0.37 1.74e-12 Fibrinogen levels; LUSC cis rs13108904 0.557 rs1680041 chr4:1238521 C/T cg20887711 chr4:1340912 KIAA1530 -0.65 -9.97 -0.48 1.11e-20 Obesity-related traits; LUSC cis rs7937682 0.924 rs1784782 chr11:111525764 A/C cg19812747 chr11:111475976 SIK2 -0.5 -7.04 -0.36 1.1e-11 Primary sclerosing cholangitis; LUSC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg23102388 chr7:1867652 MAD1L1 -0.3 -5.71 -0.3 2.44e-8 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.61 0.57 4.22e-30 Prudent dietary pattern; LUSC cis rs11758351 0.778 rs41266801 chr6:26197493 C/A cg01420254 chr6:26195488 NA 0.72 7.62 0.38 2.59e-13 Gout;Renal underexcretion gout; LUSC trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg17470723 chr8:74884337 TCEB1 0.51 7.91 0.4 3.71e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg24642439 chr20:33292090 TP53INP2 0.53 8.1 0.41 1.03e-14 Coronary artery disease; LUSC cis rs8017423 0.967 rs6575120 chr14:90725094 C/T cg14092571 chr14:90743983 NA -0.37 -6.11 -0.32 2.84e-9 Mortality in heart failure; LUSC cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.13 15.62 0.65 1.16e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg00546932 chr16:1947055 NA 0.37 5.7 0.3 2.62e-8 Glomerular filtration rate in chronic kidney disease; LUSC trans rs4596713 0.965 rs7855905 chr9:71700035 C/G cg07090356 chr18:23668764 SS18 -0.29 -6.41 -0.33 5.04e-10 Headache; LUSC cis rs2236918 1.000 rs1627006 chr1:242038004 C/T cg17736920 chr1:242011382 EXO1 0.43 6.74 0.35 6.87e-11 Menopause (age at onset); LUSC cis rs1775715 0.737 rs2799017 chr10:32203460 A/G cg04359828 chr10:32216031 ARHGAP12 0.41 7.03 0.36 1.2e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4730250 0.707 rs10953537 chr7:107027905 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.65 -0.3 3.51e-8 Osteoarthritis; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg07092213 chr7:1199455 ZFAND2A -0.44 -7.07 -0.36 9.37e-12 Longevity;Endometriosis; LUSC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg11062466 chr8:58055876 NA 0.66 8.52 0.42 5.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg00343986 chr7:65444356 GUSB 0.48 7.13 0.36 6.36e-12 Calcium levels; LUSC cis rs7618501 1.000 rs2234391 chr3:49842625 A/G cg13072238 chr3:49761600 GMPPB 0.43 7.19 0.37 4.33e-12 Intelligence (multi-trait analysis); LUSC cis rs2387326 0.671 rs11016104 chr10:129946512 G/A cg16087940 chr10:129947807 NA -0.4 -6.0 -0.31 5.04e-9 Select biomarker traits; LUSC cis rs9534288 0.659 rs2146882 chr13:46668111 A/G cg15192986 chr13:46630673 CPB2 -0.72 -10.5 -0.5 1.77e-22 Blood protein levels; LUSC trans rs9467711 0.790 rs72843784 chr6:26498758 G/T cg06606381 chr12:133084897 FBRSL1 -0.87 -7.03 -0.36 1.17e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs10486158 0.739 rs7796385 chr7:7409119 G/A cg01895333 chr3:109035405 DPPA2 -0.36 -5.95 -0.31 6.6e-9 Bipolar disorder and schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00713605 chr2:232063387 ARMC9 -0.41 -5.96 -0.31 6.41e-9 Electrocardiographic conduction measures; LUSC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.15 0.36 5.57e-12 Bipolar disorder; LUSC cis rs2180341 0.521 rs12189967 chr6:127718058 G/A cg27446573 chr6:127587934 RNF146 0.46 7.15 0.36 5.36e-12 Breast cancer; LUSC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.83e-11 Alzheimer's disease; LUSC trans rs208520 0.731 rs12206488 chr6:66999917 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 11.22 0.52 5.13e-25 Exhaled nitric oxide output; LUSC cis rs782590 0.935 rs782649 chr2:55860308 T/C cg03859395 chr2:55845619 SMEK2 0.87 16.2 0.66 5.62e-44 Metabolic syndrome; LUSC cis rs11155671 0.530 rs7757984 chr6:150208651 A/G cg09699651 chr6:150184138 LRP11 0.47 7.36 0.37 1.43e-12 Testicular germ cell tumor; LUSC cis rs6700896 0.500 rs112247468 chr1:66115008 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.36 0.33 6.62e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2281845 0.929 rs6413915 chr1:201091041 A/C cg22815214 chr1:201083145 CACNA1S -0.61 -10.71 -0.51 3.26e-23 Permanent tooth development; LUSC cis rs765787 0.530 rs2413776 chr15:45544170 A/G cg25801113 chr15:45476975 SHF 0.35 7.04 0.36 1.07e-11 Uric acid levels; LUSC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg06221963 chr1:154839813 KCNN3 -0.49 -10.21 -0.49 1.74e-21 Prostate cancer; LUSC cis rs34779708 0.966 rs17499811 chr10:35456215 G/A cg03585969 chr10:35415529 CREM 0.61 8.85 0.44 5.02e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs71435601 0.628 rs312944 chr2:21325188 A/T cg20757404 chr19:378427 NA 0.37 6.02 0.31 4.62e-9 Cholesterol, total; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg08472276 chr7:1133186 C7orf50;GPER -0.42 -6.97 -0.36 1.72e-11 Longevity;Endometriosis; LUSC cis rs4842666 0.831 rs11105378 chr12:90090741 C/T cg00757033 chr12:89920650 WDR51B 0.44 6.13 0.32 2.41e-9 Blood pressure; LUSC trans rs9886428 1.000 rs35969875 chr8:14119221 A/G cg11959399 chr20:741723 C20orf54 -0.4 -6.28 -0.32 1.05e-9 IgG glycosylation; LUSC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg09021430 chr5:549028 NA -0.56 -7.57 -0.38 3.56e-13 Obesity-related traits; LUSC trans rs6951245 0.935 rs61910751 chr7:1097895 A/G cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12541635 0.801 rs9642802 chr8:107101364 A/T cg10147462 chr8:107024639 NA -0.44 -7.74 -0.39 1.23e-13 Age of smoking initiation; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg18112904 chr7:102312315 POLR2J2 0.73 6.16 0.32 2.14e-9 Body mass index; LUSC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg20573242 chr4:122745356 CCNA2 0.43 6.63 0.34 1.35e-10 Type 2 diabetes; LUSC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg03351412 chr1:154909251 PMVK 0.41 6.09 0.32 3.15e-9 Prostate cancer; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg16614638 chr11:34073070 CAPRIN1 0.41 6.03 0.31 4.4e-9 Eotaxin levels; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg26609550 chr19:14017309 C19orf57;CC2D1A -0.43 -6.31 -0.33 8.89e-10 Hepatitis; LUSC cis rs17253792 0.822 rs10145687 chr14:56124384 T/C cg01858014 chr14:56050164 KTN1 -0.69 -6.06 -0.31 3.61e-9 Putamen volume; LUSC cis rs751728 0.687 rs4711355 chr6:33759906 G/T cg25922239 chr6:33757077 LEMD2 0.42 6.23 0.32 1.43e-9 Crohn's disease; LUSC cis rs6121246 0.512 rs45443696 chr20:30311396 A/C cg13852791 chr20:30311386 BCL2L1 0.95 14.85 0.63 1.15e-38 Mean corpuscular hemoglobin; LUSC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12756686 chr19:29218302 NA 0.68 9.99 0.48 1.02e-20 Methadone dose in opioid dependence; LUSC cis rs2370759 1.000 rs16933243 chr10:32615135 T/C cg01819863 chr10:32635814 EPC1 1.08 13.25 0.59 1.64e-32 Sexual dysfunction (female); LUSC cis rs9323205 0.773 rs4334206 chr14:51702414 G/C cg23942311 chr14:51606299 NA -0.45 -8.81 -0.43 6.82e-17 Cancer; LUSC cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg00409905 chr10:38381863 ZNF37A -0.35 -6.07 -0.32 3.56e-9 Extrinsic epigenetic age acceleration; LUSC cis rs57502260 0.704 rs55975204 chr11:68249124 C/T cg20283391 chr11:68216788 NA -0.64 -5.86 -0.31 1.14e-8 Total body bone mineral density (age 45-60); LUSC cis rs10782582 0.593 rs114421765 chr1:76141802 C/T cg10523679 chr1:76189770 ACADM -0.48 -6.96 -0.36 1.81e-11 Daytime sleep phenotypes; LUSC cis rs10979 1.000 rs12212011 chr6:143894694 C/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.25 -0.56 9.15e-29 Hypospadias; LUSC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg23758822 chr17:41437982 NA 1.0 20.45 0.75 7.78e-61 Menopause (age at onset); LUSC cis rs9815354 0.812 rs55916959 chr3:41849130 G/A cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.52e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2153904 0.793 rs1772145 chr1:205695695 C/T cg23034840 chr1:205782522 SLC41A1 0.62 7.41 0.38 1.02e-12 Prostate-specific antigen levels; LUSC trans rs7937682 1.000 rs9734135 chr11:111536190 G/A cg18187862 chr3:45730750 SACM1L 0.55 7.01 0.36 1.35e-11 Primary sclerosing cholangitis; LUSC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg12963246 chr6:28129442 ZNF389 0.49 6.73 0.35 7.47e-11 Depression; LUSC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg06022373 chr22:39101656 GTPBP1 0.76 11.33 0.53 2.05e-25 Menopause (age at onset); LUSC cis rs1712517 0.873 rs1163086 chr10:105039579 A/G cg05636881 chr10:105038444 INA 0.4 6.61 0.34 1.52e-10 Migraine; LUSC cis rs34779708 0.931 rs9663401 chr10:35278849 G/T cg04310649 chr10:35416472 CREM -0.44 -6.58 -0.34 1.85e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6547741 0.752 rs7562863 chr2:27892694 T/A cg27432699 chr2:27873401 GPN1 -0.87 -17.29 -0.69 2.78e-48 Oral cavity cancer; LUSC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg16624210 chr5:671434 TPPP 0.47 5.92 0.31 8.21e-9 Lung disease severity in cystic fibrosis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg25328477 chr19:33571995 GPATCH1 -0.46 -6.08 -0.32 3.2e-9 Hepatitis; LUSC cis rs6831352 0.959 rs6532795 chr4:100042221 C/T cg12011299 chr4:100065546 ADH4 -0.72 -11.75 -0.54 6.58e-27 Alcohol dependence; LUSC cis rs11098499 0.754 rs10006259 chr4:120242145 C/T cg09307838 chr4:120376055 NA 0.69 10.49 0.5 1.93e-22 Corneal astigmatism; LUSC cis rs9549367 0.713 rs4907598 chr13:113861385 C/T cg18105134 chr13:113819100 PROZ 0.65 9.43 0.46 7.26e-19 Platelet distribution width; LUSC cis rs4851254 0.920 rs13011874 chr2:100752497 C/T cg07810366 chr2:100720526 AFF3 -0.38 -5.86 -0.31 1.09e-8 Intelligence (multi-trait analysis); LUSC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg23719950 chr11:63933701 MACROD1 -0.38 -5.78 -0.3 1.7e-8 Platelet count; LUSC cis rs1127311 1.000 rs9427094 chr1:154557685 C/T cg17218026 chr1:154582156 ADAR 0.57 9.84 0.47 3.21e-20 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg16262614 chr3:133464971 TF 0.43 7.49 0.38 6.05e-13 Iron status biomarkers (transferrin levels); LUSC cis rs4268898 1.000 rs10165445 chr2:24441698 C/T cg06627628 chr2:24431161 ITSN2 0.61 9.09 0.45 9.2e-18 Asthma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21697007 chr12:57623759 SHMT2 -0.42 -6.16 -0.32 2.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.42 5.86 0.31 1.13e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs240764 0.853 rs1875401 chr6:101023588 G/A cg09795085 chr6:101329169 ASCC3 -0.42 -6.06 -0.31 3.78e-9 Neuroticism; LUSC cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs3771570 0.818 rs73008126 chr2:242443157 A/C cg21155796 chr2:242212141 HDLBP 0.63 6.93 0.35 2.19e-11 Prostate cancer; LUSC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg19318889 chr4:1322082 MAEA -0.7 -12.17 -0.55 1.91e-28 Obesity-related traits; LUSC cis rs2239815 0.515 rs5762829 chr22:29228130 A/G cg02153584 chr22:29168773 CCDC117 0.57 6.74 0.35 7.14e-11 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC trans rs35110281 0.591 rs189094 chr21:44932017 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 9.14 0.45 6.09e-18 Mean corpuscular volume; LUSC cis rs61931739 0.500 rs7306053 chr12:34510848 T/G cg06521331 chr12:34319734 NA -0.41 -6.8 -0.35 4.96e-11 Morning vs. evening chronotype; LUSC cis rs11051970 0.918 rs6488050 chr12:32532499 A/T cg24626660 chr12:32551988 NA 0.37 5.89 0.31 9.5e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7937682 0.855 rs7934922 chr11:111500026 T/C cg09085632 chr11:111637200 PPP2R1B -1.12 -18.21 -0.71 5.94e-52 Primary sclerosing cholangitis; LUSC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg20243544 chr17:37824526 PNMT 0.39 5.82 0.3 1.36e-8 Self-reported allergy; LUSC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg18876405 chr7:65276391 NA -0.55 -8.76 -0.43 9.78e-17 Aortic root size; LUSC cis rs208520 1.000 rs12200490 chr6:66976084 G/A cg07460842 chr6:66804631 NA 0.97 12.68 0.57 2.31e-30 Exhaled nitric oxide output; LUSC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.61 9.25 0.45 2.71e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9900062 0.546 rs2428352 chr17:62694738 C/T cg02598441 chr17:62777298 LOC146880 0.55 7.17 0.37 4.94e-12 QT interval; LUSC cis rs4319547 0.910 rs6416298 chr12:123002143 C/T cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.41 -0.42 1.25e-15 Body mass index; LUSC cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg11266682 chr4:10021025 SLC2A9 -0.5 -9.36 -0.46 1.2e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10883723 0.962 rs1056740 chr10:104236552 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 12.06 0.55 4.66e-28 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg13939156 chr17:80058883 NA 0.34 6.76 0.35 6.06e-11 Life satisfaction; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.77 -0.35 5.69e-11 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg08219700 chr8:58056026 NA 0.43 5.68 0.3 2.99e-8 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg09365446 chr1:150670422 GOLPH3L 0.51 7.5 0.38 5.68e-13 Melanoma; LUSC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg02951883 chr7:2050386 MAD1L1 -0.4 -6.85 -0.35 3.66e-11 Bipolar disorder and schizophrenia; LUSC cis rs672059 1.000 rs483783 chr1:183162152 G/T ch.1.3577855R chr1:183094577 LAMC1 0.53 8.0 0.4 2.08e-14 Hypertriglyceridemia; LUSC trans rs7824557 0.713 rs6601575 chr8:11097804 A/C cg15556689 chr8:8085844 FLJ10661 0.46 7.26 0.37 2.74e-12 Retinal vascular caliber; LUSC cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.88 -0.31 9.94e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg13736514 chr6:26305472 NA -0.45 -8.75 -0.43 1.08e-16 Educational attainment; LUSC cis rs6876348 0.598 rs1898550 chr5:128285661 C/T cg25555059 chr5:128301488 SLC27A6 -0.33 -6.03 -0.31 4.4e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.955 rs1511018 chr4:120161580 G/T cg25214090 chr10:38739885 LOC399744 0.47 6.93 0.35 2.18e-11 Corneal astigmatism; LUSC cis rs12478296 1.000 rs73007138 chr2:243007041 C/T cg06360820 chr2:242988706 NA -1.06 -10.67 -0.5 4.72e-23 Obesity-related traits; LUSC cis rs2637266 1.000 rs10824431 chr10:78356622 C/A cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg26958806 chr6:27640298 NA 0.65 5.67 0.3 3.11e-8 Depression; LUSC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg03146154 chr1:46216737 IPP -0.48 -7.26 -0.37 2.74e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12908161 0.920 rs12904605 chr15:85201419 T/C cg11189052 chr15:85197271 WDR73 0.47 5.87 0.31 1.05e-8 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05168378 chr7:100425517 EPHB4 -0.51 -6.15 -0.32 2.23e-9 Bipolar disorder and schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25000938 chr5:43484273 C5orf28 -0.37 -6.26 -0.32 1.15e-9 Triglycerides; LUSC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.93 0.31 7.45e-9 Lung cancer; LUSC cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg12463550 chr7:65579703 CRCP 0.53 7.87 0.4 4.83e-14 Aortic root size; LUSC cis rs6084875 0.840 rs6052822 chr20:4726510 T/G cg07258627 chr20:4721683 PRNT -0.34 -6.16 -0.32 2.05e-9 Systemic lupus erythematosus; LUSC cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg25427524 chr10:38739819 LOC399744 -0.72 -13.42 -0.59 3.74e-33 Extrinsic epigenetic age acceleration; LUSC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg02807482 chr3:125708958 NA -0.54 -6.69 -0.34 9.15e-11 Blood pressure (smoking interaction); LUSC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg17252645 chr8:143867129 LY6D 0.37 6.58 0.34 1.82e-10 Urinary tract infection frequency; LUSC cis rs5753618 0.539 rs1034588 chr22:31616301 A/G cg22777020 chr22:31556080 RNF185 -0.46 -5.92 -0.31 8.18e-9 Colorectal cancer; LUSC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 7.38 0.37 1.28e-12 Personality dimensions; LUSC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg13560548 chr3:10150139 C3orf24 0.52 7.42 0.38 9.94e-13 Alzheimer's disease; LUSC cis rs1044826 0.642 rs6799312 chr3:139211932 C/T cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.82e-11 Obesity-related traits; LUSC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg14893161 chr1:205819251 PM20D1 0.79 14.01 0.61 2.16e-35 Menarche (age at onset); LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg15242686 chr22:24348715 GSTTP1 0.39 5.83 0.3 1.33e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4253772 1.000 rs4253766 chr22:46623905 C/T cg09491104 chr22:46646882 C22orf40 -0.61 -7.01 -0.36 1.35e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg04865166 chr7:105162814 PUS7 0.51 5.84 0.3 1.25e-8 Bipolar disorder (body mass index interaction); LUSC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg08917208 chr2:24149416 ATAD2B 0.56 6.27 0.32 1.14e-9 Lymphocyte counts; LUSC trans rs61931739 0.517 rs11513519 chr12:34075077 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.51 0.42 5.98e-16 Morning vs. evening chronotype; LUSC cis rs7727544 0.526 rs4705908 chr5:131347520 G/A cg14196790 chr5:131705035 SLC22A5 0.45 7.38 0.37 1.3e-12 Blood metabolite levels; LUSC cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg18681998 chr4:17616180 MED28 0.83 14.97 0.63 3.9e-39 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.61 -0.38 2.92e-13 Bipolar disorder; LUSC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg03709012 chr19:19516395 GATAD2A 0.86 14.59 0.62 1.24e-37 Tonsillectomy; LUSC cis rs1957429 0.803 rs10873177 chr14:65318228 G/C cg23373153 chr14:65346875 NA 0.91 10.2 0.49 1.84e-21 Pediatric areal bone mineral density (radius); LUSC trans rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05039488 chr6:79577232 IRAK1BP1 0.57 9.22 0.45 3.49e-18 Brugada syndrome; LUSC cis rs2463822 0.925 rs6863 chr11:62160725 G/T cg06239285 chr11:62104954 ASRGL1 -0.94 -10.17 -0.49 2.5e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs3809863 0.602 rs7225700 chr17:45391804 T/C cg08085267 chr17:45401833 C17orf57 -0.64 -9.63 -0.47 1.5700000000000001e-19 Glaucoma (primary open-angle); LUSC cis rs7129556 0.520 rs6592730 chr11:77274203 T/C cg12586386 chr11:77299805 AQP11 0.23 5.71 0.3 2.49e-8 Weight loss (gastric bypass surgery); LUSC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.85 0.3 1.19e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9815354 0.680 rs73073242 chr3:42015335 G/A cg03022575 chr3:42003672 ULK4 0.76 7.6 0.38 3e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.82 -0.35 4.21e-11 Aortic root size; LUSC cis rs2479724 0.870 rs6902650 chr6:41764080 G/A cg17623882 chr6:41773611 USP49 0.63 10.34 0.49 6.28e-22 Menarche (age at onset); LUSC trans rs7937682 0.663 rs7116280 chr11:111659111 T/C cg18187862 chr3:45730750 SACM1L -0.51 -6.21 -0.32 1.57e-9 Primary sclerosing cholangitis; LUSC cis rs2439831 0.867 rs2255042 chr15:43834318 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.89 -10.29 -0.49 9.09e-22 Lung cancer in ever smokers; LUSC cis rs2273669 0.667 rs11153155 chr6:109359963 G/A cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs7824557 0.544 rs1865521 chr8:11231249 T/C cg21775007 chr8:11205619 TDH 0.71 11.27 0.52 3.47e-25 Retinal vascular caliber; LUSC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs8017423 0.935 rs7154695 chr14:90795705 C/G cg04374321 chr14:90722782 PSMC1 0.57 8.46 0.42 8.63e-16 Mortality in heart failure; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg27201871 chr17:79212816 C17orf56;C17orf89 0.4 6.09 0.32 3.03e-9 Triglycerides; LUSC trans rs724744 0.772 rs1772079 chr6:22354105 A/T cg13807341 chr11:118445984 ARCN1 0.37 6.37 0.33 6.25e-10 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7511006 1.000 rs7511006 chr22:50676259 T/C cg16473166 chr22:50639996 SELO 0.58 7.86 0.4 5.38e-14 Obesity-related traits; LUSC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs7617480 0.648 rs4974083 chr3:49000626 A/G cg21141812 chr3:48556323 PFKFB4 0.36 6.19 0.32 1.76e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs727505 0.721 rs67277928 chr7:124776704 G/T cg23710748 chr7:124431027 NA -0.39 -6.99 -0.36 1.5e-11 Lewy body disease; LUSC trans rs6819013 0.765 rs2035442 chr4:16893170 A/G cg11493509 chr11:5991173 OR56A5 0.41 6.11 0.32 2.8e-9 QT interval; LUSC cis rs4906332 1.000 rs55930273 chr14:103960298 G/A cg04998671 chr14:104000505 TRMT61A -0.45 -7.16 -0.36 5.08e-12 Coronary artery disease; LUSC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.715 rs2115401 chr16:89740609 A/G cg03605463 chr16:89740564 NA -0.61 -9.97 -0.48 1.14e-20 Vitiligo; LUSC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg24250549 chr1:154909240 PMVK 0.64 10.43 0.5 3.19e-22 Prostate cancer; LUSC cis rs7189233 0.550 rs9927982 chr16:53474108 C/T cg09728985 chr16:53543985 NA -0.31 -5.69 -0.3 2.78e-8 Intelligence (multi-trait analysis); LUSC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 16.95 0.68 6.24e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6696846 0.765 rs2836 chr1:205111761 G/T cg03948781 chr1:205179583 DSTYK -0.33 -6.48 -0.33 3.33e-10 Red blood cell count; LUSC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg13683864 chr3:40499215 RPL14 -1.02 -17.47 -0.69 5.06e-49 Renal cell carcinoma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16558908 chr1:33896237 NA -0.45 -6.38 -0.33 5.83e-10 Bipolar disorder and schizophrenia; LUSC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC trans rs8072100 0.701 rs8078309 chr17:45774072 T/C cg03886242 chr7:26192032 NFE2L3 -0.4 -6.21 -0.32 1.55e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg21782813 chr7:2030301 MAD1L1 0.35 5.83 0.3 1.27e-8 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.806 rs4888389 chr16:75395228 T/C cg03315344 chr16:75512273 CHST6 0.48 9.2 0.45 4.05e-18 Dupuytren's disease; LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.18 0.37 4.7e-12 Bipolar disorder; LUSC cis rs2734839 0.964 rs12363125 chr11:113285916 C/T cg14159747 chr11:113255604 NA 0.26 6.58 0.34 1.84e-10 Information processing speed; LUSC cis rs7927771 0.826 rs7925389 chr11:47466790 A/T cg05585544 chr11:47624801 NA -0.4 -6.87 -0.35 3.1e-11 Subjective well-being; LUSC cis rs7674212 0.570 rs2251634 chr4:104082349 C/T cg16532752 chr4:104119610 CENPE -0.5 -7.4 -0.38 1.11e-12 Type 2 diabetes; LUSC cis rs12188164 0.932 rs2230437 chr5:476353 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.41 6.8 0.35 4.81e-11 Cystic fibrosis severity; LUSC cis rs568617 0.716 rs111953392 chr11:65595697 G/A cg19792802 chr11:65647270 CTSW 0.47 6.47 0.33 3.47e-10 Crohn's disease; LUSC trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9527 0.590 rs10509764 chr10:104776475 G/A cg05855489 chr10:104503620 C10orf26 0.53 8.11 0.41 9.87e-15 Arsenic metabolism; LUSC cis rs9300255 0.544 rs10772995 chr12:123671761 T/C cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.52 -0.34 2.59e-10 Neutrophil percentage of white cells; LUSC cis rs4243830 0.850 rs10779787 chr1:6599755 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -9.64 -0.47 1.4e-19 Body mass index; LUSC cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg13319975 chr6:146136371 FBXO30 0.48 7.37 0.37 1.31e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs2425143 0.730 rs7263640 chr20:34314725 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.27 -0.32 1.14e-9 Blood protein levels; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg05025164 chr4:1340916 KIAA1530 0.42 6.68 0.34 1e-10 Longevity; LUSC cis rs1775715 0.870 rs3847415 chr10:32219456 G/T cg03015672 chr10:32216066 ARHGAP12 0.32 5.81 0.3 1.49e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg21251018 chr6:28226885 NKAPL 0.31 5.99 0.31 5.55e-9 Cardiac Troponin-T levels; LUSC cis rs116139393 0.540 rs13224907 chr7:6773892 C/T cg09896999 chr7:6746977 ZNF12 -0.51 -7.19 -0.37 4.33e-12 Alzheimer's disease (APOE e4 interaction); LUSC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg17143192 chr8:8559678 CLDN23 0.62 9.06 0.44 1.12e-17 Obesity-related traits; LUSC cis rs3820928 0.874 rs10188770 chr2:227877037 G/A cg11843606 chr2:227700838 RHBDD1 -0.55 -7.93 -0.4 3.36e-14 Pulmonary function; LUSC cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 18.25 0.71 4.18e-52 Chronic sinus infection; LUSC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.1 -0.41 1.07e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06481639 chr22:41940642 POLR3H 0.47 5.77 0.3 1.82e-8 Vitiligo; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg18033235 chr19:16989681 SIN3B 0.43 6.07 0.32 3.48e-9 Calcium levels; LUSC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg06618935 chr21:46677482 NA -0.4 -8.05 -0.4 1.48e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg06784218 chr1:46089804 CCDC17 0.49 9.41 0.46 8.49e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg07936489 chr17:37558343 FBXL20 0.73 10.18 0.49 2.22e-21 Glomerular filtration rate (creatinine); LUSC cis rs4803468 1.000 rs2241706 chr19:41912807 A/G cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.42 5.75 0.3 1.98e-8 Height; LUSC cis rs4363385 0.782 rs4845336 chr1:153003853 C/T cg00922841 chr1:152955080 SPRR1A -0.4 -6.94 -0.35 2.1e-11 Inflammatory skin disease; LUSC cis rs4595586 0.545 rs3914595 chr12:39388530 G/T cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg12560992 chr17:57184187 TRIM37 0.85 15.34 0.64 1.47e-40 Intelligence (multi-trait analysis); LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg19725989 chr11:67007604 KDM2A 0.4 6.22 0.32 1.51e-9 Mosquito bite size; LUSC cis rs75804782 0.641 rs3769125 chr2:239349562 A/G cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.37e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.93 -0.4 3.36e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs3106136 0.903 rs35361491 chr4:95202492 G/A cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.18 -0.32 1.91e-9 Capecitabine sensitivity; LUSC cis rs4654899 0.931 rs4654730 chr1:21229286 A/T cg01072550 chr1:21505969 NA -0.54 -8.08 -0.4 1.16e-14 Superior frontal gyrus grey matter volume; LUSC cis rs9814567 0.806 rs4074523 chr3:134325657 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.39 -0.56 2.83e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1044826 0.642 rs1080371 chr3:139210894 C/T cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.82e-11 Obesity-related traits; LUSC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg11965913 chr1:205819406 PM20D1 0.46 6.42 0.33 4.66e-10 Parkinson's disease; LUSC trans rs2243480 1.000 rs316322 chr7:65611233 G/C cg10756647 chr7:56101905 PSPH 0.89 8.88 0.44 4.11e-17 Diabetic kidney disease; LUSC cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs3768617 0.868 rs2296299 chr1:183104013 G/A ch.1.3577855R chr1:183094577 LAMC1 0.6 8.67 0.43 1.94e-16 Fuchs's corneal dystrophy; LUSC cis rs2997447 0.846 rs3008418 chr1:26403098 G/A cg19633962 chr1:26362018 EXTL1 -0.48 -5.76 -0.3 1.89e-8 QRS complex (12-leadsum); LUSC cis rs3820928 0.904 rs10933161 chr2:227764872 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.1e-13 Pulmonary function; LUSC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg22535103 chr8:58192502 C8orf71 -0.75 -7.83 -0.39 6.49e-14 Developmental language disorder (linguistic errors); LUSC cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg09184832 chr6:79620586 NA -0.45 -7.43 -0.38 9.27e-13 Intelligence (multi-trait analysis); LUSC cis rs7954584 0.635 rs7309024 chr12:122338334 C/T cg21171335 chr12:122356390 WDR66 0.59 8.95 0.44 2.51e-17 Mean corpuscular volume; LUSC cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg22709100 chr7:91322751 NA 0.4 5.75 0.3 2.03e-8 Breast cancer; LUSC cis rs854765 0.583 rs4077198 chr17:17834563 T/C cg04398451 chr17:18023971 MYO15A -0.48 -7.72 -0.39 1.34e-13 Total body bone mineral density; LUSC cis rs10089 1.000 rs4836369 chr5:127486462 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.88 12.44 0.56 1.93e-29 Ileal carcinoids; LUSC cis rs2742234 0.590 rs1254962 chr10:43696992 G/A cg02780029 chr10:43622663 RET 0.34 5.68 0.3 2.87e-8 Hirschsprung disease; LUSC cis rs6500395 0.963 rs4785528 chr16:48687908 A/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs67072384 1.000 rs7122017 chr11:72448558 C/G cg04827223 chr11:72435913 ARAP1 -0.79 -7.25 -0.37 2.93e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg26597838 chr10:835615 NA 0.9 12.26 0.56 8.57e-29 Eosinophil percentage of granulocytes; LUSC trans rs7615952 0.611 rs9681518 chr3:125615130 A/G cg07211511 chr3:129823064 LOC729375 -1.02 -12.68 -0.57 2.4e-30 Blood pressure (smoking interaction); LUSC trans rs334147 1.000 rs334140 chr2:128235148 A/G cg06224766 chr8:120499470 NA -0.61 -6.04 -0.31 4.11e-9 Educational attainment; LUSC cis rs12711979 1.000 rs6542655 chr2:3872434 T/C cg17052675 chr2:3827356 NA -0.44 -7.87 -0.4 5.15e-14 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs6815814 0.950 rs5743557 chr4:38806827 G/A cg02016764 chr4:38805732 TLR1 -0.54 -5.92 -0.31 7.93e-9 Breast cancer; LUSC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs7824557 0.564 rs7828263 chr8:11231886 A/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.25 -0.32 1.26e-9 Retinal vascular caliber; LUSC cis rs7474896 0.559 rs1735641 chr10:38184852 C/A cg25427524 chr10:38739819 LOC399744 0.45 5.83 0.3 1.34e-8 Obesity (extreme); LUSC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg27165867 chr14:105738592 BRF1 0.51 7.56 0.38 3.87e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg26314531 chr2:26401878 FAM59B -0.7 -9.75 -0.47 6.29e-20 Gut microbiome composition (summer); LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg26314531 chr2:26401878 FAM59B 0.68 8.9 0.44 3.71e-17 Gut microbiome composition (summer); LUSC cis rs763121 0.962 rs5757130 chr22:38937794 G/A cg06544989 chr22:39130855 UNC84B 0.33 5.79 0.3 1.59e-8 Menopause (age at onset); LUSC cis rs7208859 0.623 rs11652631 chr17:29060766 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.44 -0.33 4.14e-10 Total body bone mineral density; LUSC cis rs9902453 0.619 rs2255489 chr17:28084974 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.93 -0.44 2.92e-17 Coffee consumption (cups per day); LUSC trans rs11696501 0.694 rs6073827 chr20:44265556 T/C cg03272292 chr12:48577362 C12orf68 0.49 5.98 0.31 5.75e-9 Brain structure; LUSC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg09034736 chr1:150693464 HORMAD1 0.45 6.5 0.34 2.91e-10 Melanoma; LUSC cis rs1595825 0.891 rs16825917 chr2:198805185 C/T cg10547527 chr2:198650123 BOLL -0.49 -5.68 -0.3 3e-8 Ulcerative colitis; LUSC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.52 -6.95 -0.36 1.88e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg12463550 chr7:65579703 CRCP 0.52 7.59 0.38 3.16e-13 Aortic root size; LUSC trans rs7737355 1.000 rs12719444 chr5:130607378 C/T cg07715041 chr7:99302981 CYP3A7 -0.38 -6.03 -0.31 4.27e-9 Life satisfaction; LUSC trans rs629535 0.590 rs62513427 chr8:70138891 A/T cg21567404 chr3:27674614 NA -0.94 -13.31 -0.59 1.01e-32 Dupuytren's disease; LUSC trans rs1493916 0.905 rs10460051 chr18:31413679 C/T cg15819921 chr19:927150 ARID3A -0.44 -6.53 -0.34 2.41e-10 Life satisfaction; LUSC trans rs10097669 0.679 rs2725067 chr8:4438113 T/C cg16451306 chr5:71475356 MAP1B 0.3 6.4 0.33 5.15e-10 Trans fatty acid levels; LUSC cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg22117172 chr7:91764530 CYP51A1 0.32 5.65 0.3 3.5e-8 Breast cancer; LUSC cis rs559928 0.593 rs112275221 chr11:63936994 C/T cg05555928 chr11:63887634 MACROD1 -0.49 -6.05 -0.31 3.95e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs4474465 0.790 rs7932315 chr11:78214878 G/A cg27205649 chr11:78285834 NARS2 0.51 5.92 0.31 7.81e-9 Alzheimer's disease (survival time); LUSC cis rs9303280 0.901 rs921650 chr17:38069076 G/A cg10909506 chr17:38081995 ORMDL3 -0.34 -6.28 -0.33 1.03e-9 Self-reported allergy; LUSC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg27266060 chr8:22091797 NA -0.37 -6.85 -0.35 3.65e-11 Hypertriglyceridemia; LUSC cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.55 0.42 4.63e-16 Menarche (age at onset); LUSC cis rs34779708 0.966 rs34630580 chr10:35449228 A/G cg04310649 chr10:35416472 CREM -0.42 -6.45 -0.33 4.02e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg10523679 chr1:76189770 ACADM 0.87 12.45 0.56 1.77e-29 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.58 0.34 1.86e-10 Lung cancer; LUSC cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.86 8.41 0.42 1.19e-15 Lung cancer in ever smokers; LUSC trans rs8073060 0.586 rs7212488 chr17:33993476 A/T cg19694781 chr19:47549865 TMEM160 -1.16 -18.75 -0.72 4.22e-54 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg11764359 chr7:65958608 NA -0.78 -12.8 -0.57 8.35e-31 Aortic root size; LUSC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg00074818 chr8:8560427 CLDN23 0.58 9.91 0.48 1.88e-20 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08111106 chr17:4901164 INCA1;KIF1C -0.43 -6.18 -0.32 1.82e-9 Electrocardiographic conduction measures; LUSC cis rs4629180 1.000 rs59246268 chr2:102089021 G/A cg01388757 chr2:102091195 RFX8 -0.45 -7.1 -0.36 7.61e-12 Chronic rhinosinusitis with nasal polyps; LUSC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg04315214 chr1:2043799 PRKCZ 0.48 10.09 0.48 4.68e-21 Height; LUSC cis rs12421382 0.659 rs979603 chr11:109384996 A/G cg16359550 chr11:109292809 C11orf87 -0.32 -5.69 -0.3 2.79e-8 Schizophrenia; LUSC cis rs2236918 1.000 rs2995544 chr1:242020495 C/T cg17736920 chr1:242011382 EXO1 0.47 7.41 0.38 1.03e-12 Menopause (age at onset); LUSC cis rs9467711 0.517 rs16901784 chr6:26555433 C/A cg12826209 chr6:26865740 GUSBL1 0.68 6.04 0.31 4.03e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg18382599 chr1:43124310 PPIH 0.48 6.01 0.31 4.79e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.28e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg10729496 chr3:10149963 C3orf24 -0.47 -6.12 -0.32 2.66e-9 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07285953 chr17:27572551 CRYBA1 -0.42 -6.87 -0.35 3.17e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12410462 0.579 rs77529417 chr1:227547895 T/C cg10327440 chr1:227177885 CDC42BPA -0.67 -6.41 -0.33 4.99e-10 Major depressive disorder; LUSC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg11752832 chr7:134001865 SLC35B4 0.52 7.82 0.39 6.78e-14 Mean platelet volume; LUSC cis rs11122272 0.735 rs2739509 chr1:231526765 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg03433033 chr1:76189801 ACADM 0.83 13.25 0.59 1.78e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.3 -5.66 -0.3 3.27e-8 Lymphocyte counts; LUSC cis rs34638657 0.732 rs11645372 chr16:82202136 C/T cg09439754 chr16:82129088 HSD17B2 -0.39 -6.45 -0.33 3.97e-10 Lung adenocarcinoma; LUSC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg20503657 chr10:835505 NA 1.19 16.28 0.67 2.87e-44 Eosinophil percentage of granulocytes; LUSC cis rs72717009 0.825 rs61802846 chr1:161473873 A/C cg23840854 chr1:161414152 NA -0.92 -11.22 -0.52 5.42e-25 Rheumatoid arthritis; LUSC cis rs9039 1.000 rs11862745 chr16:9218887 C/T cg08831531 chr16:9218945 NA 0.66 10.57 0.5 1e-22 Menopause (age at onset); LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg10802521 chr3:52805072 NEK4 -0.58 -9.1 -0.45 8.23e-18 Bipolar disorder; LUSC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg11871910 chr12:69753446 YEATS4 0.67 10.16 0.49 2.61e-21 Blood protein levels; LUSC cis rs7771547 0.642 rs1003250 chr6:36437412 A/G cg07856975 chr6:36356162 ETV7 -0.35 -6.34 -0.33 7.26e-10 Platelet distribution width; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24015817 chr6:96025855 MANEA 0.44 6.19 0.32 1.74e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs853679 0.517 rs36078605 chr6:28078032 A/C cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.49e-9 Depression; LUSC cis rs699 0.583 rs2493150 chr1:230868427 C/T cg07502417 chr1:230849801 AGT 0.25 5.92 0.31 7.9e-9 Coronary artery disease; LUSC cis rs28595532 0.800 rs111626798 chr4:119352517 C/T cg02775129 chr4:119771670 NA -0.8 -6.59 -0.34 1.7e-10 Cannabis dependence symptom count; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.81 -15.17 -0.64 6.88e-40 Prudent dietary pattern; LUSC cis rs2708377 0.929 rs2708334 chr12:11269668 G/A cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs1577917 0.771 rs9362239 chr6:86429263 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.52 8.25 0.41 3.76e-15 Response to antipsychotic treatment; LUSC cis rs739401 0.869 rs395188 chr11:3072631 A/G cg25174290 chr11:3078921 CARS -0.5 -7.5 -0.38 5.81e-13 Longevity; LUSC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg00310523 chr12:86230176 RASSF9 0.51 9.68 0.47 1.07e-19 Major depressive disorder; LUSC cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.46 -0.46 5.63e-19 Chronic sinus infection; LUSC cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.98 0.72 5.41e-55 Chronic sinus infection; LUSC trans rs11098499 0.954 rs10024844 chr4:120311528 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg06641503 chr3:48959341 ARIH2 -0.39 -5.88 -0.31 9.73e-9 Parkinson's disease; LUSC trans rs12439619 0.739 rs4778988 chr15:82540337 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.52 -8.06 -0.4 1.38e-14 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.35 -5.67 -0.3 3.09e-8 Total body bone mineral density; LUSC cis rs6967414 0.605 rs7786706 chr7:6747267 C/T cg09896999 chr7:6746977 ZNF12 -0.6 -7.58 -0.38 3.37e-13 Hematocrit;Hemoglobin concentration; LUSC cis rs6547741 0.967 rs4665996 chr2:27814343 T/C cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 3.16e-39 Oral cavity cancer; LUSC cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.39 -0.33 5.48e-10 Monocyte percentage of white cells; LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg22907277 chr7:1156413 C7orf50 0.49 7.31 0.37 2.04e-12 Longevity;Endometriosis; LUSC cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs5758659 0.652 rs133327 chr22:42407689 T/C cg04733989 chr22:42467013 NAGA 0.39 6.55 0.34 2.22e-10 Cognitive function; LUSC cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg15605315 chr1:45957053 TESK2 -0.44 -6.81 -0.35 4.52e-11 High light scatter reticulocyte count; LUSC cis rs1882538 0.551 rs6974618 chr7:133084031 C/A cg10665199 chr7:133106180 EXOC4 0.57 8.22 0.41 4.6e-15 Intelligence (multi-trait analysis); LUSC cis rs8060686 0.516 rs8048364 chr16:68253324 T/G cg05110241 chr16:68378359 PRMT7 -0.46 -5.95 -0.31 6.6e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7937682 0.575 rs7127010 chr11:111770782 C/T cg09085632 chr11:111637200 PPP2R1B 0.96 13.3 0.59 1.14e-32 Primary sclerosing cholangitis; LUSC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg23262073 chr20:60523788 NA -0.42 -5.84 -0.3 1.21e-8 Body mass index; LUSC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg10130564 chr11:117069849 TAGLN 0.31 5.99 0.31 5.49e-9 Blood protein levels; LUSC cis rs7428496 0.528 rs3923464 chr3:142225388 G/A cg16271453 chr3:142027066 XRN1 -0.51 -8.95 -0.44 2.6e-17 Mean corpuscular hemoglobin; LUSC cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.9 -11.47 -0.53 6.48e-26 Chronic sinus infection; LUSC cis rs12464483 0.524 rs2256411 chr2:30886860 C/A cg07150166 chr2:30669952 LCLAT1 0.58 6.52 0.34 2.63e-10 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.87 -0.35 3.2e-11 Lung cancer; LUSC cis rs524023 0.957 rs528211 chr11:64351721 C/T cg19131476 chr11:64387923 NRXN2 0.37 9.89 0.48 2.11e-20 Urate levels in obese individuals; LUSC cis rs4363385 0.720 rs1984197 chr1:152962915 C/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.65 -0.39 2.21e-13 Inflammatory skin disease; LUSC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg10523679 chr1:76189770 ACADM 0.86 11.41 0.53 1.11e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2708377 0.929 rs7487324 chr12:11299218 C/T cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.6 -5.72 -0.3 2.32e-8 Cerebrospinal P-tau181p levels; LUSC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg17264618 chr3:40429014 ENTPD3 0.32 6.8 0.35 4.89e-11 Renal cell carcinoma; LUSC cis rs9325144 0.560 rs2387923 chr12:38662677 G/A cg13010199 chr12:38710504 ALG10B -0.53 -8.1 -0.41 1.03e-14 Morning vs. evening chronotype; LUSC cis rs2274459 0.841 rs2281918 chr6:33663055 G/A cg06253072 chr6:33679850 C6orf125 0.48 5.76 0.3 1.94e-8 Obesity (extreme); LUSC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg11752832 chr7:134001865 SLC35B4 0.59 9.29 0.45 2.08e-18 Mean platelet volume; LUSC cis rs6681460 0.565 rs6689755 chr1:67113050 G/A cg02459107 chr1:67143332 SGIP1 0.43 7.96 0.4 2.65e-14 Presence of antiphospholipid antibodies; LUSC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg11764359 chr7:65958608 NA -0.7 -10.83 -0.51 1.31e-23 Aortic root size; LUSC cis rs919433 0.679 rs6757669 chr2:198530355 C/T cg00792783 chr2:198669748 PLCL1 0.42 5.66 0.3 3.23e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg15083158 chr17:2615176 KIAA0664 0.64 6.04 0.31 4.06e-9 Body mass index; LUSC cis rs61931739 0.513 rs1486889 chr12:33901229 A/G cg06521331 chr12:34319734 NA -0.35 -5.68 -0.3 2.98e-8 Morning vs. evening chronotype; LUSC cis rs10875746 0.551 rs1471998 chr12:48712002 C/T cg13454099 chr12:49076203 C12orf41 -0.5 -5.78 -0.3 1.69e-8 Longevity (90 years and older); LUSC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg25566285 chr7:158114605 PTPRN2 -0.33 -6.22 -0.32 1.5e-9 Calcium levels; LUSC cis rs7267979 1.000 rs6076339 chr20:25348712 T/C cg03522245 chr20:25566470 NINL -0.35 -5.71 -0.3 2.53e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.83 -14.2 -0.61 4e-36 Menarche (age at onset); LUSC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.31e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2991971 1.000 rs2991970 chr1:46011005 C/T cg24296786 chr1:45957014 TESK2 0.47 6.8 0.35 4.8e-11 High light scatter reticulocyte count; LUSC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg06238570 chr21:40685208 BRWD1 0.51 7.73 0.39 1.26e-13 Cognitive function; LUSC cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.62 0.43 2.64e-16 Menarche (age at onset); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21318521 chr6:107349259 C6orf203 -0.47 -6.2 -0.32 1.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs7246967 0.611 rs3951784 chr19:22851926 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs6542838 0.641 rs4553869 chr2:99505940 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -5.97 -0.31 5.98e-9 Fear of minor pain; LUSC cis rs1881396 0.947 rs77350364 chr2:27866139 A/G cg27432699 chr2:27873401 GPN1 0.64 8.61 0.43 3.03e-16 Nonalcoholic fatty liver disease; LUSC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg13319975 chr6:146136371 FBXO30 0.46 6.97 0.36 1.7e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2898290 0.622 rs13272061 chr8:11352261 G/T cg21775007 chr8:11205619 TDH -0.48 -7.1 -0.36 7.46e-12 Systolic blood pressure; LUSC cis rs7215564 0.908 rs4969246 chr17:78740579 G/A cg23238734 chr17:78661607 RPTOR -0.45 -5.73 -0.3 2.24e-8 Myopia (pathological); LUSC cis rs7572644 0.723 rs3935148 chr2:28020966 T/A cg27432699 chr2:27873401 GPN1 0.58 7.5 0.38 5.86e-13 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg13628971 chr7:2884303 GNA12 -0.49 -7.24 -0.37 3.15e-12 Height; LUSC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.17 -0.32 1.95e-9 Alzheimer's disease (late onset); LUSC cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg03146154 chr1:46216737 IPP 0.51 7.59 0.38 3.1400000000000003e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4595586 0.545 rs12814188 chr12:39380853 C/T cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.27 0.52 3.49e-25 Menopause (age at onset); LUSC cis rs34779708 0.966 rs57081218 chr10:35434608 A/G cg03585969 chr10:35415529 CREM 0.59 8.73 0.43 1.28e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2742417 0.603 rs2673055 chr3:45772772 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.25 -0.37 2.97e-12 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01161889 chr6:27145367 NA -0.45 -6.01 -0.31 4.77e-9 Hepatitis; LUSC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg23625390 chr15:77176239 SCAPER 0.49 7.44 0.38 8.57e-13 Blood metabolite levels; LUSC cis rs710216 0.536 rs710221 chr1:43414200 G/A cg03128534 chr1:43423976 SLC2A1 0.64 11.01 0.52 2.96e-24 Red cell distribution width; LUSC trans rs11681884 0.892 rs56948778 chr2:113853893 C/T cg09636715 chr7:27217057 HOXA10 0.73 6.12 0.32 2.61e-9 Stroke; LUSC cis rs6430585 0.702 rs2015532 chr2:136555525 G/T cg07169764 chr2:136633963 MCM6 -1.09 -15.67 -0.65 7.19e-42 Corneal structure; LUSC trans rs208520 0.526 rs7776413 chr6:66783241 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.23 -25.83 -0.82 1.29e-81 Exhaled nitric oxide output; LUSC cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg14690467 chr7:148917905 ZNF282 -0.25 -5.7 -0.3 2.59e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs58688157 0.960 rs702966 chr11:611919 C/G cg07212818 chr11:638076 DRD4 -0.38 -6.51 -0.34 2.79e-10 Systemic lupus erythematosus; LUSC trans rs877282 0.898 rs11253350 chr10:765968 G/A cg22713356 chr15:30763199 NA 1.07 14.17 0.61 5.24e-36 Uric acid levels; LUSC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg18099408 chr3:52552593 STAB1 -0.35 -5.97 -0.31 6.05e-9 Electroencephalogram traits; LUSC cis rs1107366 0.695 rs10934754 chr3:125906237 T/C cg08481491 chr3:125900108 ALDH1L1 -0.28 -5.69 -0.3 2.85e-8 Metabolite levels; LUSC trans rs7824557 0.564 rs35009431 chr8:11232788 G/A cg15556689 chr8:8085844 FLJ10661 -0.54 -8.21 -0.41 5.02e-15 Retinal vascular caliber; LUSC trans rs1728785 1.000 rs1615609 chr16:68596401 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.22 0.41 4.57e-15 Ulcerative colitis; LUSC cis rs1371867 0.810 rs3020182 chr8:101233008 T/C cg06636551 chr8:101224915 SPAG1 0.47 8.73 0.43 1.25e-16 Atrioventricular conduction; LUSC cis rs4954585 0.683 rs4072434 chr2:137014023 C/G cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.79e-13 Colorectal cancer; LUSC cis rs17826219 0.706 rs8075107 chr17:29106649 C/A cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Body mass index; LUSC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9611565 0.592 rs12484467 chr22:41957610 T/C cg06634786 chr22:41940651 POLR3H -0.59 -6.85 -0.35 3.65e-11 Vitiligo; LUSC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg17264618 chr3:40429014 ENTPD3 0.34 7.14 0.36 6e-12 Renal cell carcinoma; LUSC trans rs8072100 0.817 rs9912101 chr17:45547078 A/G cg03886242 chr7:26192032 NFE2L3 -0.42 -6.67 -0.34 1.03e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6433857 0.505 rs12471899 chr2:181369856 C/T cg23363182 chr2:181467187 NA -0.44 -7.08 -0.36 8.68e-12 Body mass index; LUSC cis rs10791097 0.667 rs12363163 chr11:130744509 A/G cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs61931739 0.817 rs11833948 chr12:34276942 G/T cg26384229 chr12:38710491 ALG10B 0.55 9.02 0.44 1.48e-17 Morning vs. evening chronotype; LUSC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.63 -0.39 2.46e-13 Blood metabolite levels; LUSC cis rs7043114 0.525 rs10820964 chr9:95041636 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.46 -0.33 3.63e-10 Height; LUSC cis rs713587 0.713 rs11125884 chr2:25239264 C/T cg01884057 chr2:25150051 NA 0.38 8.71 0.43 1.42e-16 Body mass index in non-asthmatics; LUSC cis rs244293 0.965 rs244298 chr17:53241387 C/T cg19360675 chr17:53046073 COX11;STXBP4 -0.39 -5.66 -0.3 3.26e-8 Menarche (age at onset); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24423897 chr19:4723980 DPP9 0.38 6.03 0.31 4.46e-9 Triglycerides; LUSC cis rs929354 0.713 rs6946947 chr7:156948787 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg24154853 chr7:158122151 PTPRN2 0.45 8.75 0.43 1.06e-16 Calcium levels; LUSC cis rs2522056 1.000 rs2706393 chr5:131796067 G/A cg24060327 chr5:131705240 SLC22A5 0.45 5.96 0.31 6.39e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs763121 0.853 rs5757141 chr22:38957483 G/A cg14440974 chr22:39074834 NA -0.39 -6.34 -0.33 7.58e-10 Menopause (age at onset); LUSC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg27432699 chr2:27873401 GPN1 -0.55 -8.24 -0.41 3.99e-15 Total body bone mineral density; LUSC cis rs12200560 0.505 rs59296768 chr6:97075535 C/T cg06623918 chr6:96969491 KIAA0776 0.5 7.2 0.37 3.9e-12 Coronary heart disease; LUSC cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.32 0.33 8.34e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC trans rs4332037 0.522 rs4721098 chr7:1881527 G/C cg11693508 chr17:37793320 STARD3 -0.52 -6.54 -0.34 2.36e-10 Bipolar disorder; LUSC cis rs7681440 0.626 rs1372510 chr4:90817259 G/A cg20003494 chr4:90757398 SNCA -0.35 -5.87 -0.31 1.07e-8 Dementia with Lewy bodies; LUSC cis rs2732480 0.577 rs1489108 chr12:48738781 G/A cg04545296 chr12:48745243 ZNF641 0.37 6.79 0.35 5.1e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4622329 0.615 rs7305951 chr12:102294501 C/T cg23541617 chr12:102225335 GNPTAB 0.25 5.97 0.31 6.17e-9 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15253204 chr10:123687610 ATE1 -0.41 -6.15 -0.32 2.25e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2692947 0.637 rs72492201 chr2:96630201 G/A cg23100626 chr2:96804247 ASTL 0.26 6.26 0.32 1.2e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 8.03e-17 Prudent dietary pattern; LUSC cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg05347473 chr6:146136440 FBXO30 0.58 10.26 0.49 1.21e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs35883536 0.647 rs17402665 chr1:101046940 C/T cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC cis rs11098499 0.604 rs2389882 chr4:120566733 A/C cg24375607 chr4:120327624 NA 0.71 10.4 0.49 3.84e-22 Corneal astigmatism; LUSC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg06481639 chr22:41940642 POLR3H -0.53 -5.96 -0.31 6.38e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg23172400 chr8:95962367 TP53INP1 -0.34 -6.46 -0.33 3.72e-10 Type 2 diabetes; LUSC trans rs4295623 0.504 rs11250160 chr8:11592717 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -8.37 -0.42 1.62e-15 Morning vs. evening chronotype; LUSC cis rs17095355 0.901 rs12569425 chr10:111758177 G/A cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.35 -0.37 1.53e-12 Biliary atresia; LUSC cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg03146154 chr1:46216737 IPP 0.52 7.65 0.39 2.1e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00860370 chr1:104068121 RNPC3 0.47 6.34 0.33 7.37e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1950626 0.750 rs34228453 chr14:101440321 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.77 0.39 9.82e-14 Pelvic organ prolapse (moderate/severe); LUSC cis rs9653442 0.593 rs4851273 chr2:100848321 A/G cg07810366 chr2:100720526 AFF3 -0.41 -6.66 -0.34 1.12e-10 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs11264799 0.520 rs849819 chr1:157541674 A/C cg18268488 chr1:157545234 FCRL4 0.39 7.69 0.39 1.7e-13 IgA nephropathy; LUSC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg18876405 chr7:65276391 NA -0.74 -13.35 -0.59 7.01e-33 Aortic root size; LUSC cis rs7131987 0.845 rs7299861 chr12:29409667 G/A cg09582351 chr12:29534625 ERGIC2 -0.3 -6.25 -0.32 1.28e-9 QT interval; LUSC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg00933542 chr6:150070202 PCMT1 0.31 6.45 0.33 3.83e-10 Lung cancer; LUSC cis rs7949030 0.929 rs11231173 chr11:62418921 T/A cg13298116 chr11:62369859 EML3;MTA2 0.52 8.6 0.43 3.04e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8099014 0.906 rs4940693 chr18:56101171 T/G cg12907477 chr18:56117327 MIR122 0.46 6.78 0.35 5.45e-11 Platelet count; LUSC cis rs7647973 0.710 rs6446284 chr3:49616997 A/G cg07636037 chr3:49044803 WDR6 0.55 5.69 0.3 2.82e-8 Menarche (age at onset); LUSC cis rs10876993 0.928 rs1689595 chr12:58056763 C/T cg15848620 chr12:58087721 OS9 -0.55 -7.93 -0.4 3.34e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg18230493 chr5:56204884 C5orf35 -0.55 -8.75 -0.43 1.06e-16 Coronary artery disease; LUSC cis rs983392 0.805 rs2123314 chr11:59966295 C/T cg24026212 chr11:59952134 MS4A6A 0.38 6.78 0.35 5.5e-11 Alzheimer's disease (late onset); LUSC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg01579765 chr21:45077557 HSF2BP -0.57 -11.91 -0.55 1.66e-27 Mean corpuscular volume; LUSC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg23791538 chr6:167370224 RNASET2 -0.36 -5.67 -0.3 3.05e-8 Crohn's disease; LUSC cis rs10979 1.000 rs9376756 chr6:143886125 C/T cg25407410 chr6:143891975 LOC285740 -0.63 -10.35 -0.49 5.69e-22 Hypospadias; LUSC trans rs2243480 1.000 rs1796228 chr7:66033084 G/A cg10756647 chr7:56101905 PSPH 0.89 9.05 0.44 1.19e-17 Diabetic kidney disease; LUSC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg26897989 chr16:1907736 C16orf73 -0.45 -7.02 -0.36 1.28e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs1577917 0.959 rs34258068 chr6:86679449 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.45 -6.64 -0.34 1.26e-10 Response to antipsychotic treatment; LUSC cis rs7949030 1.000 rs10897289 chr11:62400016 T/C cg11742103 chr11:62369870 EML3;MTA2 0.48 8.14 0.41 8.07e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg14195823 chr19:39926698 RPS16 -0.41 -5.98 -0.31 5.63e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4729127 1.000 rs79645457 chr7:93989950 T/G cg20086523 chr13:52378287 DHRS12 0.58 6.16 0.32 2.04e-9 Intelligence; LUSC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg08677398 chr8:58056175 NA 0.61 6.96 0.36 1.83e-11 Developmental language disorder (linguistic errors); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07156844 chr16:88729753 MGC23284;MVD 0.37 6.28 0.32 1.03e-9 Asthma; LUSC cis rs11658309 1 rs11658309 chr17:17762247 T/G cg16928487 chr17:17741425 SREBF1 0.45 8.88 0.44 4.18e-17 Strep throat; LUSC trans rs8026898 0.501 rs1426072 chr15:69979459 C/G cg13594869 chr14:86088946 FLRT2 -0.37 -5.98 -0.31 5.81e-9 Rheumatoid arthritis; LUSC cis rs9583531 0.689 rs6492308 chr13:111377829 T/C cg24331049 chr13:111365604 ING1 0.6 8.28 0.41 2.9e-15 Coronary artery disease; LUSC cis rs2836633 0.895 rs2836598 chr21:40024758 C/G cg05519781 chr21:40033154 ERG 0.75 12.54 0.57 8.19e-30 Coronary artery disease; LUSC cis rs11677370 0.574 rs11686118 chr2:3854938 C/T cg17052675 chr2:3827356 NA -0.63 -9.66 -0.47 1.29e-19 Type 2 diabetes; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg24291203 chr8:100025000 VPS13B 0.54 6.81 0.35 4.5e-11 Cognitive function;Information processing speed; LUSC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.65 9.87 0.48 2.53e-20 Height; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20604927 chr2:153575133 ARL6IP6;PRPF40A -0.42 -6.21 -0.32 1.61e-9 Electrocardiographic conduction measures; LUSC cis rs62103177 0.564 rs2115996 chr18:77701007 C/G cg20368463 chr18:77673604 PQLC1 0.68 6.9 0.35 2.6e-11 Opioid sensitivity; LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg05165339 chr4:1420672 NA -0.3 -6.94 -0.35 2.09e-11 Longevity; LUSC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg11752832 chr7:134001865 SLC35B4 0.56 8.78 0.43 8.45e-17 Mean platelet volume; LUSC trans rs1325195 0.881 rs10913697 chr1:179088744 G/A cg11624085 chr17:8464688 MYH10 -0.44 -7.38 -0.37 1.25e-12 IgE grass sensitization; LUSC cis rs4144743 0.759 rs16941731 chr17:45317022 C/T cg18085866 chr17:45331354 ITGB3 0.75 7.39 0.37 1.23e-12 Body mass index; LUSC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -7.63 -0.39 2.53e-13 Platelet count; LUSC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg17143192 chr8:8559678 CLDN23 -0.65 -9.47 -0.46 5.16e-19 Obesity-related traits; LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 11.09 0.52 1.52e-24 Alzheimer's disease; LUSC cis rs4588572 0.606 rs6859161 chr5:77742776 A/G cg11547950 chr5:77652471 NA -0.46 -6.74 -0.35 7.08e-11 Triglycerides; LUSC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg16447950 chr5:562315 NA -0.55 -7.1 -0.36 7.47e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6570726 1.000 rs1935615 chr6:145921117 G/T cg05347473 chr6:146136440 FBXO30 0.41 6.63 0.34 1.38e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg20135002 chr11:47629003 NA -0.5 -7.78 -0.39 8.99e-14 Subjective well-being; LUSC cis rs2637266 0.807 rs2256413 chr10:78315334 C/T cg18941641 chr10:78392320 NA -0.34 -5.86 -0.31 1.13e-8 Pulmonary function; LUSC cis rs6489882 0.902 rs1981557 chr12:113372866 G/C cg20102336 chr12:113376681 OAS3 -0.42 -6.03 -0.31 4.29e-9 Chronic lymphocytic leukemia; LUSC cis rs12620999 1.000 rs11689249 chr2:238083542 T/A cg23555395 chr2:238036564 NA -0.47 -8.21 -0.41 4.92e-15 Systemic lupus erythematosus; LUSC cis rs73198271 0.740 rs964771 chr8:8650939 A/G cg01851573 chr8:8652454 MFHAS1 -0.54 -8.85 -0.44 5.22e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg06238570 chr21:40685208 BRWD1 0.48 7.37 0.37 1.34e-12 Cognitive function; LUSC cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg26924012 chr15:45694286 SPATA5L1 1.12 19.82 0.74 2.37e-58 Homoarginine levels; LUSC cis rs9467773 0.935 rs1056668 chr6:26510605 C/T cg12292205 chr6:26970375 C6orf41 0.38 5.94 0.31 7.33e-9 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg23985595 chr17:80112537 CCDC57 0.3 5.81 0.3 1.43e-8 Life satisfaction; LUSC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg14196790 chr5:131705035 SLC22A5 0.44 6.93 0.35 2.13e-11 Breast cancer;Mosquito bite size; LUSC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg20503657 chr10:835505 NA 0.78 9.73 0.47 7.08e-20 Eosinophil percentage of granulocytes; LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg23758822 chr17:41437982 NA 1.04 20.11 0.74 1.65e-59 Menopause (age at onset); LUSC cis rs7107174 1.000 rs2450129 chr11:77940385 T/C cg02023728 chr11:77925099 USP35 0.53 7.39 0.38 1.16e-12 Testicular germ cell tumor; LUSC cis rs9888739 1.000 rs12928810 chr16:31311715 G/A cg15817542 chr16:31343056 ITGAM -0.5 -6.1 -0.32 2.98e-9 Systemic lupus erythematosus; LUSC cis rs56346965 0.506 rs2159818 chr2:191532789 A/G cg11845111 chr2:191398756 TMEM194B -0.43 -5.98 -0.31 5.83e-9 Bone mineral density (Ward's triangle area); LUSC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg04455712 chr21:45112962 RRP1B 0.45 8.39 0.42 1.4e-15 Mean corpuscular volume; LUSC trans rs11098499 0.754 rs17049949 chr4:120255290 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.45 0.33 4.03e-10 Corneal astigmatism; LUSC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg13393036 chr8:95962371 TP53INP1 -0.32 -6.24 -0.32 1.34e-9 Type 2 diabetes; LUSC cis rs7903847 0.596 rs10786340 chr10:99156563 G/C cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs1997103 0.906 rs6593231 chr7:55402914 T/A cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9527 0.662 rs10786714 chr10:104598606 G/C cg04362960 chr10:104952993 NT5C2 0.62 8.71 0.43 1.39e-16 Arsenic metabolism; LUSC cis rs73206853 0.841 rs28772589 chr12:110845040 C/T cg12870014 chr12:110450643 ANKRD13A 0.68 7.09 0.36 8.16e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.31 0.53 2.56e-25 Menopause (age at onset); LUSC trans rs7824557 0.564 rs55758514 chr8:11230259 A/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.08 -0.4 1.22e-14 Retinal vascular caliber; LUSC cis rs722599 0.683 rs8014695 chr14:75301617 C/G cg08847533 chr14:75593920 NEK9 0.44 6.21 0.32 1.58e-9 IgG glycosylation; LUSC cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg04450456 chr4:17643702 FAM184B 0.37 6.12 0.32 2.66e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg01884057 chr2:25150051 NA 0.46 10.77 0.51 2.08e-23 Body mass index; LUSC cis rs9929218 0.954 rs9929479 chr16:68821271 G/C cg02972257 chr16:68554789 NA 0.42 5.69 0.3 2.72e-8 Colorectal cancer; LUSC cis rs1801251 1.000 rs2044449 chr2:233718808 G/A cg25237894 chr2:233734115 C2orf82 -0.36 -6.77 -0.35 5.79e-11 Coronary artery disease; LUSC cis rs3743266 0.507 rs56261931 chr15:60731618 C/T cg21667061 chr15:60772094 NARG2 0.52 7.25 0.37 2.86e-12 Menarche (age at onset); LUSC cis rs11098499 1.000 rs11726229 chr4:120211580 C/T cg09307838 chr4:120376055 NA 0.71 10.07 0.48 5.18e-21 Corneal astigmatism; LUSC cis rs8044995 0.706 rs111948678 chr16:68255959 G/A cg09835421 chr16:68378352 PRMT7 -0.59 -6.31 -0.33 8.82e-10 Schizophrenia; LUSC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg00343986 chr7:65444356 GUSB -0.43 -6.63 -0.34 1.32e-10 Aortic root size; LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.43 -0.33 4.47e-10 Menopause (age at onset); LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg16325326 chr1:53192061 ZYG11B 0.89 16.36 0.67 1.39e-44 Monocyte count; LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg17541715 chr7:1216824 NA -0.42 -6.64 -0.34 1.3e-10 Longevity;Endometriosis; LUSC trans rs11039798 0.588 rs7108164 chr11:48626363 A/C cg03929089 chr4:120376271 NA 0.59 6.44 0.33 4.04e-10 Axial length; LUSC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg22105103 chr4:187893119 NA -0.7 -13.57 -0.6 1.06e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs4888262 0.508 rs12598701 chr16:74539904 G/A cg01733217 chr16:74700730 RFWD3 0.74 12.38 0.56 3.13e-29 Testicular germ cell tumor; LUSC cis rs9660992 0.674 rs12122105 chr1:205256818 C/T cg00857998 chr1:205179979 DSTYK 0.62 9.51 0.46 3.81e-19 Mean corpuscular volume;Mean platelet volume; LUSC trans rs561341 0.714 rs55925849 chr17:30253085 C/T cg20587970 chr11:113659929 NA -1.27 -17.35 -0.69 1.62e-48 Hip circumference adjusted for BMI; LUSC cis rs10832963 1.000 rs10128711 chr11:18632984 A/G cg09201001 chr11:18656081 SPTY2D1 0.91 14.69 0.63 4.87e-38 Breast cancer; LUSC cis rs61931739 0.534 rs4539411 chr12:34014807 T/C cg06521331 chr12:34319734 NA -0.51 -8.38 -0.42 1.51e-15 Morning vs. evening chronotype; LUSC cis rs6754311 0.550 rs12994270 chr2:136518103 T/A cg25344623 chr2:136566232 LCT 0.37 5.69 0.3 2.84e-8 Mosquito bite size; LUSC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg15147215 chr3:52552868 STAB1 -0.32 -6.3 -0.33 9.6e-10 Bipolar disorder; LUSC cis rs9815354 0.812 rs73077360 chr3:41850054 C/T cg03022575 chr3:42003672 ULK4 0.86 8.66 0.43 2.07e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2046867 0.774 rs1393585 chr3:72886722 A/G cg25664220 chr3:72788482 NA -0.67 -10.69 -0.51 3.8e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs8060686 0.641 rs7192187 chr16:68132109 T/C cg26727032 chr16:67993705 SLC12A4 -0.42 -5.79 -0.3 1.62e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg20295408 chr7:1910781 MAD1L1 -0.49 -7.17 -0.37 4.96e-12 Bipolar disorder and schizophrenia; LUSC cis rs1371867 0.846 rs1660326 chr8:101290447 G/A cg00191853 chr8:101177733 SPAG1 -0.39 -6.21 -0.32 1.6e-9 Atrioventricular conduction; LUSC cis rs7666738 0.546 rs10026181 chr4:98814118 C/T cg03676636 chr4:99064102 C4orf37 -0.29 -5.66 -0.3 3.22e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg08859206 chr1:53392774 SCP2 0.55 9.48 0.46 5.03e-19 Monocyte count; LUSC cis rs7587476 0.784 rs36086595 chr2:215680293 A/G cg04004882 chr2:215674386 BARD1 0.48 6.38 0.33 5.77e-10 Neuroblastoma; LUSC trans rs17039065 1.000 rs78569046 chr4:109393475 A/G cg07444054 chr2:108107501 NA 0.43 6.3 0.33 9.24e-10 Gut microbiome composition (summer); LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg25036284 chr2:26402008 FAM59B 0.71 10.01 0.48 8.34e-21 Gut microbiome composition (summer); LUSC cis rs12579753 0.956 rs7309624 chr12:82204266 C/A cg07988820 chr12:82153109 PPFIA2 -0.43 -6.12 -0.32 2.69e-9 Resting heart rate; LUSC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17604090 0.775 rs73090343 chr7:29688768 T/C cg19413766 chr7:29689036 LOC646762 -0.64 -8.0 -0.4 2.01e-14 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -6.21 -0.32 1.61e-9 Developmental language disorder (linguistic errors); LUSC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg20887711 chr4:1340912 KIAA1530 0.41 6.18 0.32 1.91e-9 Longevity; LUSC cis rs11758351 1.000 rs11758351 chr6:26203910 T/G cg23601095 chr6:26197514 HIST1H3D 0.74 7.88 0.4 4.59e-14 Gout;Renal underexcretion gout; LUSC cis rs250677 1.000 rs36080 chr5:148430451 A/G cg23229984 chr5:148520753 ABLIM3 0.37 6.05 0.31 3.85e-9 Breast cancer; LUSC cis rs9311676 0.609 rs6770113 chr3:58379297 C/A cg26110898 chr3:58419937 PDHB 0.42 6.83 0.35 4.07e-11 Systemic lupus erythematosus; LUSC cis rs2708977 0.637 rs676007 chr2:97075052 G/A cg01950434 chr2:97203154 ARID5A -0.45 -6.24 -0.32 1.36e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs77633900 0.772 rs157775 chr15:76755641 A/G cg21673338 chr15:77095150 SCAPER -0.7 -6.07 -0.32 3.53e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg05896524 chr21:47604654 C21orf56 0.41 6.0 0.31 5.04e-9 Testicular germ cell tumor; LUSC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg17986701 chr20:44574422 PCIF1 0.38 6.72 0.34 7.98e-11 Intelligence (multi-trait analysis); LUSC cis rs11997175 0.603 rs4739382 chr8:33807012 C/T ch.8.33884649F chr8:33765107 NA 0.43 6.52 0.34 2.55e-10 Body mass index; LUSC cis rs9393777 0.920 rs34150729 chr6:27388754 T/C cg09904177 chr6:26538194 HMGN4 -0.8 -6.05 -0.31 3.85e-9 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg11766577 chr21:47581405 C21orf56 -0.46 -6.96 -0.36 1.83e-11 Testicular germ cell tumor; LUSC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg22834771 chr12:69754056 YEATS4 -0.49 -7.4 -0.38 1.14e-12 Blood protein levels; LUSC cis rs9660992 0.736 rs1180734 chr1:205255438 A/G cg21545522 chr1:205238299 TMCC2 0.46 8.7 0.43 1.5e-16 Mean corpuscular volume;Mean platelet volume; LUSC trans rs11992162 0.560 rs13256329 chr8:11782214 G/A cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.46e-10 Monocyte count; LUSC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg27266027 chr21:40555129 PSMG1 -0.41 -6.05 -0.31 3.8e-9 Cognitive function; LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg25767906 chr1:53392781 SCP2 0.53 9.76 0.47 5.79e-20 Monocyte count; LUSC cis rs9287719 0.934 rs6432115 chr2:10748343 G/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg10729496 chr3:10149963 C3orf24 0.52 6.93 0.35 2.21e-11 Alzheimer's disease; LUSC cis rs7917772 0.582 rs10786698 chr10:104378750 G/A cg05855489 chr10:104503620 C10orf26 -0.49 -7.38 -0.37 1.28e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.19 0.64 5.67e-40 Bladder cancer; LUSC cis rs73206853 0.563 rs73194032 chr12:111162182 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.52 0.38 5.1e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.13 -0.45 6.62e-18 Monocyte percentage of white cells; LUSC cis rs12799172 0.710 rs11041007 chr11:6786001 A/C cg01145442 chr11:6790970 OR2AG2 0.34 5.64 0.3 3.55e-8 Periodontal disease-related phenotypes; LUSC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.2 -0.37 4.09e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.6 8.36 0.42 1.75e-15 Alzheimer's disease; LUSC cis rs1728785 0.901 rs1170437 chr16:68607943 C/T cg02972257 chr16:68554789 NA -0.5 -6.18 -0.32 1.91e-9 Ulcerative colitis; LUSC cis rs12210905 0.925 rs12193820 chr6:27113811 A/G cg11502198 chr6:26597334 ABT1 -0.79 -5.71 -0.3 2.45e-8 Hip circumference adjusted for BMI; LUSC cis rs3820068 0.608 rs6668919 chr1:16049893 A/G cg17385448 chr1:15911702 AGMAT -0.34 -5.73 -0.3 2.27e-8 Systolic blood pressure; LUSC cis rs2708377 0.929 rs2600340 chr12:11261589 T/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs9549260 0.564 rs4941989 chr13:41299687 T/C cg21288729 chr13:41239152 FOXO1 0.53 7.88 0.4 4.59e-14 Red blood cell count; LUSC cis rs6977660 0.607 rs12113916 chr7:19781424 G/T cg07541023 chr7:19748670 TWISTNB 0.68 6.79 0.35 5.11e-11 Thyroid stimulating hormone; LUSC cis rs3771570 0.901 rs56129392 chr2:242242439 C/T cg21155796 chr2:242212141 HDLBP 0.67 7.52 0.38 5.23e-13 Prostate cancer; LUSC cis rs7833787 0.965 rs6586777 chr8:18702471 A/C cg17701159 chr8:18705777 PSD3 0.39 6.38 0.33 5.93e-10 Obesity-related traits; LUSC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg00343986 chr7:65444356 GUSB -0.43 -6.55 -0.34 2.17e-10 Aortic root size; LUSC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.17 -0.37 4.91e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg03676636 chr4:99064102 C4orf37 -0.34 -7.47 -0.38 7.08e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg06873352 chr17:61820015 STRADA 0.57 8.78 0.43 8.9e-17 Height; LUSC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2742234 0.868 rs2505512 chr10:43633596 G/A cg02780029 chr10:43622663 RET -0.34 -6.24 -0.32 1.35e-9 Hirschsprung disease; LUSC cis rs11166629 1.000 rs3739423 chr8:135614705 A/G cg27224718 chr8:135614730 ZFAT 0.67 10.8 0.51 1.61e-23 Smoking quantity; LUSC cis rs593982 0.920 rs487264 chr11:65481465 A/C cg08755490 chr11:65554678 OVOL1 1.47 13.15 0.58 4.26e-32 Atopic dermatitis; LUSC cis rs12579753 1.000 rs17692461 chr12:82171755 C/G cg21231944 chr12:82153410 PPFIA2 -0.39 -5.94 -0.31 7.25e-9 Resting heart rate; LUSC cis rs4285028 0.580 rs12496036 chr3:121640362 G/A cg11130432 chr3:121712080 ILDR1 -0.5 -8.33 -0.41 2.08e-15 Multiple sclerosis; LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg13685833 chr1:53393034 SCP2 -0.39 -5.86 -0.31 1.11e-8 Monocyte count; LUSC cis rs897984 0.759 rs13708 chr16:31000809 G/A cg02466173 chr16:30829666 NA 0.56 11.11 0.52 1.3e-24 Dementia with Lewy bodies; LUSC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg13722127 chr7:150037890 RARRES2 0.39 5.85 0.31 1.14e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg18512352 chr11:47633146 NA -0.48 -9.65 -0.47 1.38e-19 Subjective well-being; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12355862 chr5:148205911 ADRB2 0.39 6.03 0.31 4.31e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs453301 0.522 rs2929455 chr8:9083433 A/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.23 -0.37 3.33e-12 Joint mobility (Beighton score); LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg22868518 chr11:507468 RNH1 -0.65 -6.15 -0.32 2.27e-9 Body mass index; LUSC cis rs983392 0.719 rs610932 chr11:59939307 T/G cg24026212 chr11:59952134 MS4A6A 0.33 5.95 0.31 6.89e-9 Alzheimer's disease (late onset); LUSC cis rs71403859 0.554 rs12373065 chr16:71870032 T/A cg08717414 chr16:71523259 ZNF19 -0.58 -5.88 -0.31 9.84e-9 Post bronchodilator FEV1; LUSC cis rs4776059 0.798 rs2414167 chr15:52907428 A/G cg25063058 chr15:52860530 ARPP19 -0.44 -5.71 -0.3 2.57e-8 Schizophrenia; LUSC cis rs8072100 0.875 rs62073966 chr17:45600013 T/A cg25173405 chr17:45401733 C17orf57 0.37 5.85 0.3 1.17e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs11608355 1.000 rs930356 chr12:109852372 T/C cg05360138 chr12:110035743 NA 0.46 6.31 0.33 8.72e-10 Neuroticism; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg15147215 chr3:52552868 STAB1 0.31 6.53 0.34 2.52e-10 Electroencephalogram traits; LUSC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg10729496 chr3:10149963 C3orf24 0.54 7.17 0.37 4.98e-12 Alzheimer's disease; LUSC cis rs68170813 0.559 rs3823959 chr7:107009379 T/G cg02696742 chr7:106810147 HBP1 -0.64 -9.56 -0.46 2.74e-19 Coronary artery disease; LUSC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg02034447 chr16:89574710 SPG7 0.42 6.33 0.33 7.77e-10 Multiple myeloma (IgH translocation); LUSC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.71e-13 Bipolar disorder; LUSC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg26850624 chr5:429559 AHRR -0.42 -7.91 -0.4 3.74e-14 Cystic fibrosis severity; LUSC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg13877915 chr19:58951672 ZNF132 0.47 7.44 0.38 8.84e-13 Uric acid clearance; LUSC trans rs4729127 1.000 rs60238694 chr7:94008118 C/T cg20086523 chr13:52378287 DHRS12 0.54 6.31 0.33 9.11e-10 Intelligence; LUSC cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.81 0.51 1.48e-23 Bladder cancer; LUSC cis rs2479724 0.792 rs7739064 chr6:41834037 C/A cg17623882 chr6:41773611 USP49 -0.62 -10.36 -0.49 5.22e-22 Menarche (age at onset); LUSC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg15352829 chr14:105391018 PLD4 -0.42 -8.89 -0.44 3.84e-17 Rheumatoid arthritis; LUSC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg08704250 chr15:31115839 NA -0.45 -6.97 -0.36 1.68e-11 Huntington's disease progression; LUSC cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg06784218 chr1:46089804 CCDC17 0.56 11.13 0.52 1.11e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2303282 0.933 rs9929724 chr16:56535613 A/C cg00500540 chr16:56394104 NA -0.45 -7.26 -0.37 2.66e-12 Breast cancer; LUSC trans rs1493916 1.000 rs990882 chr18:31398180 T/G cg13755796 chr4:20253514 NA -0.43 -6.59 -0.34 1.69e-10 Life satisfaction; LUSC cis rs2233152 0.572 rs10403040 chr19:41296046 A/T cg21869046 chr19:41225005 ITPKC -0.48 -7.16 -0.36 5.12e-12 Kawasaki disease; LUSC cis rs2730245 0.527 rs842693 chr7:158660491 C/T cg24397884 chr7:158709396 WDR60 0.78 8.95 0.44 2.56e-17 Height; LUSC trans rs4332037 0.539 rs1533827 chr7:2074290 A/G cg10840412 chr1:235813424 GNG4 -0.55 -7.14 -0.36 5.78e-12 Bipolar disorder; LUSC cis rs477692 0.905 rs489966 chr10:131422115 C/G cg05714579 chr10:131428358 MGMT -0.47 -7.22 -0.37 3.62e-12 Response to temozolomide; LUSC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg09034736 chr1:150693464 HORMAD1 0.45 6.43 0.33 4.36e-10 Melanoma; LUSC cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg22906224 chr7:99728672 NA 0.53 7.82 0.39 7.08e-14 Coronary artery disease; LUSC trans rs453301 0.653 rs11784393 chr8:8903134 C/T cg21775007 chr8:11205619 TDH 0.45 6.47 0.33 3.59e-10 Joint mobility (Beighton score); LUSC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg24154853 chr7:158122151 PTPRN2 0.45 8.87 0.44 4.48e-17 Calcium levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06839777 chr6:122720676 HSF2 -0.44 -6.63 -0.34 1.39e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7100689 0.646 rs1340382 chr10:82096997 G/C cg01528321 chr10:82214614 TSPAN14 0.83 12.43 0.56 2.11e-29 Post bronchodilator FEV1; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg02018176 chr4:1364513 KIAA1530 0.56 10.41 0.49 3.64e-22 Longevity; LUSC cis rs554111 0.679 rs906254 chr1:21324760 G/A cg01072550 chr1:21505969 NA 0.4 6.07 0.31 3.57e-9 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs2692947 0.673 rs2229169 chr2:96780716 T/G cg23100626 chr2:96804247 ASTL -0.3 -7.15 -0.36 5.67e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24802771 chr4:331610 ZNF141 -0.42 -6.05 -0.31 3.89e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg09184832 chr6:79620586 NA -0.45 -7.43 -0.38 9.27e-13 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg07701084 chr6:150067640 NUP43 0.56 8.46 0.42 8.31e-16 Lung cancer; LUSC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg13918804 chr1:2043761 PRKCZ 0.27 5.76 0.3 1.86e-8 Height; LUSC cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg00409905 chr10:38381863 ZNF37A -0.36 -6.29 -0.33 9.8e-10 Extrinsic epigenetic age acceleration; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg05863683 chr7:1912471 MAD1L1 0.31 6.12 0.32 2.68e-9 Bipolar disorder and schizophrenia; LUSC cis rs6545883 0.860 rs4671399 chr2:61458518 C/T cg15711740 chr2:61764176 XPO1 0.43 6.8 0.35 4.87e-11 Tuberculosis; LUSC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg13319975 chr6:146136371 FBXO30 0.5 7.6 0.38 3.04e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs16917546 0.935 rs10995271 chr10:64438486 G/C cg03961010 chr10:64397487 ZNF365 -0.39 -6.12 -0.32 2.65e-9 Basal cell carcinoma; LUSC cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg23791538 chr6:167370224 RNASET2 -0.36 -5.69 -0.3 2.76e-8 Crohn's disease; LUSC cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg24558204 chr6:135376177 HBS1L 0.68 10.81 0.51 1.43e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02858162 chr2:122512910 TSN 0.46 6.19 0.32 1.72e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2991971 1.000 rs606542 chr1:46013933 T/C cg24296786 chr1:45957014 TESK2 0.47 6.86 0.35 3.33e-11 High light scatter reticulocyte count; LUSC cis rs11030122 0.673 rs4910590 chr11:4018619 C/T cg08557956 chr11:4115526 RRM1 -0.46 -5.89 -0.31 9.45e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC trans rs2243480 1.000 rs56291018 chr7:65390339 G/A cg10756647 chr7:56101905 PSPH 0.89 8.63 0.43 2.6e-16 Diabetic kidney disease; LUSC cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg19875535 chr5:140030758 IK -0.55 -9.1 -0.45 8.22e-18 Depressive symptoms (multi-trait analysis); LUSC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg05110241 chr16:68378359 PRMT7 -0.57 -6.5 -0.33 3.01e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs2230307 0.536 rs496798 chr1:100507990 G/A cg24955406 chr1:100503596 HIAT1 0.57 6.15 0.32 2.23e-9 Carotid intima media thickness; LUSC cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg13798780 chr7:105162888 PUS7 0.57 6.16 0.32 2.05e-9 Bipolar disorder (body mass index interaction); LUSC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg20887711 chr4:1340912 KIAA1530 -0.49 -7.36 -0.37 1.4e-12 Obesity-related traits; LUSC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.2 -0.37 4e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4595586 0.545 rs12828866 chr12:39391925 C/A cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs2282300 0.739 rs1631451 chr11:30349133 G/C cg25418670 chr11:30344373 C11orf46 -0.64 -9.27 -0.45 2.28e-18 Morning vs. evening chronotype; LUSC cis rs2439831 0.764 rs12324584 chr15:43683446 G/T cg02155558 chr15:43621948 ADAL;LCMT2 1.03 12.62 0.57 3.89e-30 Lung cancer in ever smokers; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06210887 chr1:156471006 MEF2D 0.55 7.61 0.38 2.83e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1172822 0.665 rs897796 chr19:55831589 A/G cg04391588 chr19:55832610 TMEM150B 0.29 5.79 0.3 1.65e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs6500395 0.928 rs4785532 chr16:48695500 G/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.84 -0.35 3.75e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC cis rs11997175 0.625 rs7825931 chr8:33583627 A/C ch.8.33884649F chr8:33765107 NA -0.4 -6.35 -0.33 7.03e-10 Body mass index; LUSC cis rs5758511 0.680 rs5758652 chr22:42612408 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.89 -0.31 9.19e-9 Birth weight; LUSC cis rs5758659 0.904 rs134877 chr22:42662371 C/T cg04733989 chr22:42467013 NAGA 0.4 6.45 0.33 3.96e-10 Cognitive function; LUSC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg14196790 chr5:131705035 SLC22A5 -0.42 -6.93 -0.35 2.14e-11 Breast cancer;Mosquito bite size; LUSC trans rs4664304 0.629 rs57751799 chr2:160854180 A/T cg05371993 chr16:1458494 UNKL 0.41 6.01 0.31 4.74e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs478304 0.651 rs11537193 chr11:65500003 A/C cg27068330 chr11:65405492 SIPA1 -0.76 -10.88 -0.51 8.57e-24 Acne (severe); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04208734 chr7:73270063 NA -0.53 -6.29 -0.33 1e-9 Bipolar disorder and schizophrenia; LUSC cis rs2204008 0.618 rs8186932 chr12:38338386 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.49 -0.38 6.11e-13 Bladder cancer; LUSC cis rs870825 0.550 rs57301026 chr4:185646505 C/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs1729951 0.514 rs75977 chr3:136700549 C/A cg21827317 chr3:136751795 NA 0.38 6.89 0.35 2.73e-11 Neuroticism; LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg07507251 chr3:52567010 NT5DC2 0.36 7.0 0.36 1.39e-11 Bipolar disorder; LUSC cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg08999081 chr20:33150536 PIGU 0.44 8.08 0.4 1.19e-14 Coronary artery disease; LUSC cis rs1728785 1.000 rs7205960 chr16:68565604 G/C cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs3820928 1.000 rs10193316 chr2:227777650 A/G cg11843606 chr2:227700838 RHBDD1 -0.55 -8.07 -0.4 1.32e-14 Pulmonary function; LUSC cis rs7481584 0.581 rs105686 chr11:3062467 G/A cg05729581 chr11:3078854 CARS 0.41 6.14 0.32 2.35e-9 Calcium levels; LUSC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg24531977 chr5:56204891 C5orf35 -0.62 -9.2 -0.45 3.87e-18 Coronary artery disease; LUSC cis rs68170813 0.559 rs74898466 chr7:107053998 C/A cg02696742 chr7:106810147 HBP1 -0.61 -8.98 -0.44 1.96e-17 Coronary artery disease; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.28 0.56 7.31e-29 Prudent dietary pattern; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24767315 chr2:241525811 CAPN10 -0.45 -6.73 -0.35 7.18e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg22709100 chr7:91322751 NA 0.39 5.74 0.3 2.13e-8 Breast cancer; LUSC cis rs4478858 0.735 rs3806255 chr1:31791578 A/G cg00250761 chr1:31883323 NA -0.35 -8.75 -0.43 1.09e-16 Alcohol dependence; LUSC cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg04756594 chr16:24857601 SLC5A11 0.35 5.77 0.3 1.81e-8 Intelligence (multi-trait analysis); LUSC cis rs6977660 1.000 rs6974669 chr7:19793296 T/A cg07541023 chr7:19748670 TWISTNB 0.59 6.74 0.35 6.88e-11 Thyroid stimulating hormone; LUSC trans rs6951245 0.872 rs75398423 chr7:1098414 T/G cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12594515 1.000 rs7172161 chr15:45990780 A/G cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.45 5.73 0.3 2.19e-8 Renal function-related traits (BUN); LUSC cis rs17767294 0.803 rs59701161 chr6:27646117 T/C cg08851530 chr6:28072375 NA 0.92 6.13 0.32 2.54e-9 Parkinson's disease; LUSC cis rs1124376 1.000 rs1124376 chr3:20108546 A/G cg05072819 chr3:20081367 KAT2B -0.61 -6.63 -0.34 1.34e-10 Bipolar disorder and schizophrenia; LUSC cis rs3768617 0.510 rs2027083 chr1:183088330 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.56e-24 Fuchs's corneal dystrophy; LUSC cis rs17270561 0.666 rs4711099 chr6:25741809 C/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18159230 chr1:169076004 ATP1B1 -0.48 -6.2 -0.32 1.64e-9 Bipolar disorder and schizophrenia; LUSC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg05729581 chr11:3078854 CARS -0.58 -9.0 -0.44 1.78e-17 Longevity; LUSC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.21 -0.49 1.79e-21 Platelet count; LUSC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg02564969 chr6:151773285 C6orf211;RMND1 -0.46 -6.86 -0.35 3.25e-11 Menarche (age at onset); LUSC cis rs854765 0.562 rs2955381 chr17:17945500 G/C cg04398451 chr17:18023971 MYO15A 0.57 9.53 0.46 3.41e-19 Total body bone mineral density; LUSC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg11247378 chr22:39784982 NA -0.65 -13.23 -0.59 2.05e-32 Intelligence (multi-trait analysis); LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg27535305 chr1:53392650 SCP2 -0.37 -6.89 -0.35 2.86e-11 Monocyte count; LUSC cis rs7216064 1.000 rs62085992 chr17:65923083 T/A cg12091567 chr17:66097778 LOC651250 -0.76 -9.59 -0.46 2.18e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7762018 0.607 rs77972667 chr6:170130456 G/C cg19338460 chr6:170058176 WDR27 -0.99 -8.07 -0.4 1.27e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC trans rs9388451 0.874 rs3734634 chr6:126111800 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.35 -0.46 1.33e-18 Brugada syndrome; LUSC cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg08999081 chr20:33150536 PIGU 0.53 10.66 0.5 4.78e-23 Coronary artery disease; LUSC cis rs713587 0.563 rs7591460 chr2:25103967 A/C cg04586622 chr2:25135609 ADCY3 0.39 7.94 0.4 3.1e-14 Body mass index in non-asthmatics; LUSC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs3540 0.574 rs2526000 chr15:90962626 C/T cg04176472 chr15:90893244 GABARAPL3 0.33 5.98 0.31 5.61e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg16584290 chr5:462447 EXOC3 -0.37 -6.43 -0.33 4.39e-10 Cystic fibrosis severity; LUSC cis rs6599077 0.616 rs9834531 chr3:40173809 A/T cg13683864 chr3:40499215 RPL14 0.45 6.05 0.31 3.8e-9 Sleep-related phenotypes; LUSC cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg25427524 chr10:38739819 LOC399744 -0.57 -10.02 -0.48 7.74e-21 Extrinsic epigenetic age acceleration; LUSC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg05754148 chr16:3507555 NAT15 0.53 8.09 0.4 1.08e-14 Tuberculosis; LUSC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12667521 chr19:29218732 NA 0.62 9.36 0.46 1.19e-18 Methadone dose in opioid dependence; LUSC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg13114125 chr14:105738426 BRF1 0.92 16.14 0.66 9.84e-44 Mean platelet volume;Platelet distribution width; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03004097 chr2:239197782 PER2 -0.35 -6.17 -0.32 1.99e-9 Electrocardiographic conduction measures; LUSC trans rs72674100 1.000 rs77899474 chr4:97952494 C/A cg16405019 chr1:18959625 PAX7 -0.62 -6.45 -0.33 3.85e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg06219351 chr7:158114137 PTPRN2 -0.52 -9.51 -0.46 3.88e-19 Calcium levels; LUSC cis rs6121246 0.567 rs6060249 chr20:30190944 G/A cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs9733 0.680 rs3738484 chr1:150552330 G/T cg09365446 chr1:150670422 GOLPH3L -0.41 -5.94 -0.31 7.12e-9 Tonsillectomy; LUSC cis rs7246657 0.550 rs10411176 chr19:37686953 G/T cg23950597 chr19:37808831 NA -0.6 -5.96 -0.31 6.46e-9 Coronary artery calcification; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02335971 chr8:121457381 MTBP;MRPL13 -0.48 -6.13 -0.32 2.45e-9 Bipolar disorder and schizophrenia; LUSC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg01097406 chr16:89675127 NA 0.3 5.69 0.3 2.72e-8 Multiple myeloma (IgH translocation); LUSC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg13939156 chr17:80058883 NA 0.34 6.61 0.34 1.52e-10 Life satisfaction; LUSC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg00701064 chr4:6280414 WFS1 0.6 15.3 0.64 1.99e-40 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg03916912 chr11:95522834 CEP57;FAM76B -0.84 -13.98 -0.61 2.77e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9318086 0.904 rs9580769 chr13:24439724 T/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.4 -6.08 -0.32 3.25e-9 Myopia (pathological); LUSC cis rs11637783 1 rs11637783 chr15:79139000 T/C cg00540400 chr15:79124168 NA -0.33 -5.69 -0.3 2.85e-8 Coronary artery disease; LUSC cis rs11871801 0.517 rs646123 chr17:40720632 G/A cg16308533 chr17:40838983 CNTNAP1 0.41 6.07 0.32 3.49e-9 Crohn's disease; LUSC cis rs7937682 0.924 rs6589244 chr11:111534333 T/C cg22437258 chr11:111473054 SIK2 0.48 6.35 0.33 6.88e-10 Primary sclerosing cholangitis; LUSC cis rs11758351 0.866 rs77889957 chr6:26207435 A/G cg01420254 chr6:26195488 NA 0.64 7.28 0.37 2.35e-12 Gout;Renal underexcretion gout; LUSC cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg08807101 chr21:30365312 RNF160 -0.8 -14.96 -0.63 4.46e-39 Dental caries; LUSC cis rs9329221 0.935 rs3750310 chr8:10283426 G/A cg21775007 chr8:11205619 TDH -0.52 -7.33 -0.37 1.76e-12 Neuroticism; LUSC cis rs6582630 0.638 rs4882309 chr12:38448595 A/G cg26384229 chr12:38710491 ALG10B -0.54 -8.19 -0.41 5.7e-15 Drug-induced liver injury (flucloxacillin); LUSC trans rs2727020 0.575 rs10769587 chr11:49549849 C/G cg03929089 chr4:120376271 NA -0.95 -16.12 -0.66 1.23e-43 Coronary artery disease; LUSC cis rs4378355 1 rs4378355 chr11:34783417 G/C cg06937548 chr11:34938143 PDHX;APIP 0.41 5.86 0.31 1.09e-8 Prostate-specific antigen levels; LUSC cis rs4555082 0.874 rs11622166 chr14:105759763 C/A cg13114125 chr14:105738426 BRF1 -0.92 -14.78 -0.63 2.28e-38 Mean platelet volume;Platelet distribution width; LUSC cis rs8060686 0.641 rs12599880 chr16:68152035 A/G cg09835421 chr16:68378352 PRMT7 -0.55 -6.17 -0.32 1.92e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs68170813 0.522 rs12535814 chr7:107038432 A/T cg02696742 chr7:106810147 HBP1 -0.61 -8.88 -0.44 4.17e-17 Coronary artery disease; LUSC cis rs554111 0.656 rs3121071 chr1:21128420 C/T cg01072550 chr1:21505969 NA 0.38 5.72 0.3 2.4e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC trans rs6601327 0.641 rs11782886 chr8:9587891 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.4 -0.33 5.21e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg09491104 chr22:46646882 C22orf40 -0.64 -7.39 -0.37 1.22e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs10761482 0.861 rs7096250 chr10:62106319 C/A cg18175470 chr10:62150864 ANK3 -0.54 -7.78 -0.39 9.31e-14 Schizophrenia; LUSC cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg23158103 chr7:148848205 ZNF398 -0.5 -8.15 -0.41 7.35e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2637266 0.783 rs860167 chr10:78532936 A/G cg18941641 chr10:78392320 NA 0.35 6.38 0.33 5.84e-10 Pulmonary function; LUSC cis rs6906287 0.669 rs6913012 chr6:118973137 G/A cg21191810 chr6:118973309 C6orf204 0.34 6.32 0.33 8.48e-10 Electrocardiographic conduction measures; LUSC cis rs11190604 1.000 rs9420782 chr10:102235015 G/A cg07080220 chr10:102295463 HIF1AN 0.62 8.5 0.42 6.24e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12476592 0.602 rs262472 chr2:63833616 G/A cg10828910 chr2:63850056 LOC388955 0.5 5.81 0.3 1.49e-8 Childhood ear infection; LUSC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.96 0.4 2.64e-14 Prudent dietary pattern; LUSC cis rs67366981 1.000 rs67130018 chr14:77703280 C/T cg22824376 chr14:77648248 TMEM63C 0.69 6.44 0.33 4.23e-10 Obsessive-compulsive symptoms; LUSC cis rs79911532 0.515 rs111356249 chr7:75716527 A/G cg03592824 chr7:75666768 STYXL1 0.67 6.39 0.33 5.42e-10 Mononucleosis; LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC trans rs11039798 0.623 rs594615 chr11:48402804 T/C cg03929089 chr4:120376271 NA -0.59 -6.27 -0.32 1.13e-9 Axial length; LUSC cis rs6969780 0.778 rs11564055 chr7:27145350 A/G cg26364809 chr7:27145159 NA -0.59 -5.98 -0.31 5.69e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs73071352 0.588 rs55744136 chr3:41812293 A/C cg03022575 chr3:42003672 ULK4 0.85 8.67 0.43 1.87e-16 Multiple myeloma and monoclonal gammopathy;Multiple myeloma; LUSC cis rs6500395 1.000 rs11859909 chr16:48668441 T/C cg04672837 chr16:48644449 N4BP1 0.46 6.91 0.35 2.41e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs5758511 0.573 rs2267438 chr22:42237565 C/T cg03131358 chr22:42195972 CCDC134 -0.33 -5.75 -0.3 2.01e-8 Birth weight; LUSC trans rs7829975 0.681 rs2271342 chr8:8643938 C/T cg21775007 chr8:11205619 TDH 0.45 6.49 0.33 3.03e-10 Mood instability; LUSC cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg24690094 chr11:67383802 NA -0.49 -9.98 -0.48 1.1e-20 Mean corpuscular volume; LUSC cis rs7786808 0.564 rs10267128 chr7:158198490 G/A cg01191920 chr7:158217561 PTPRN2 0.48 9.47 0.46 5.21e-19 Obesity-related traits; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg01298356 chr11:64889837 FAU;MRPL49 0.46 7.18 0.37 4.69e-12 Schizophrenia; LUSC cis rs7584330 0.617 rs10202195 chr2:238352128 A/G cg14458575 chr2:238380390 NA 0.69 11.77 0.54 5.54e-27 Prostate cancer; LUSC cis rs2273669 0.667 rs11755471 chr6:109342169 T/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 8.89e-9 Prostate cancer; LUSC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg20607798 chr8:58055168 NA 0.53 5.78 0.3 1.73e-8 Developmental language disorder (linguistic errors); LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg11843238 chr5:131593191 PDLIM4 -0.4 -6.55 -0.34 2.16e-10 Breast cancer; LUSC cis rs2249625 0.564 rs2463734 chr6:72882558 C/T cg18830697 chr6:72922368 RIMS1 -0.37 -7.38 -0.37 1.25e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC trans rs853679 0.607 rs13199906 chr6:27834139 C/G cg01620082 chr3:125678407 NA -0.82 -7.32 -0.37 1.84e-12 Depression; LUSC cis rs1577917 0.958 rs7747897 chr6:86647349 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg18230493 chr5:56204884 C5orf35 0.58 9.16 0.45 5.22e-18 Coronary artery disease; LUSC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.64 -0.39 2.27e-13 Personality dimensions; LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg06387496 chr7:2775674 GNA12 -0.37 -5.71 -0.3 2.51e-8 Height; LUSC cis rs72634258 0.679 rs7523227 chr1:8180097 G/A cg26816564 chr1:7831052 VAMP3 0.47 6.17 0.32 1.92e-9 Inflammatory bowel disease; LUSC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.46 0.38 7.55e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs13385 0.769 rs28450136 chr5:139598090 A/G cg26211634 chr5:139558579 C5orf32 0.45 6.81 0.35 4.63e-11 Atrial fibrillation; LUSC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.64 0.57 3.49e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg27535305 chr1:53392650 SCP2 0.39 7.3 0.37 2.07e-12 Monocyte count; LUSC cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg15839431 chr19:19639596 YJEFN3 0.64 7.27 0.37 2.55e-12 Bipolar disorder; LUSC trans rs8073060 0.586 rs7208672 chr17:33989759 G/A cg19694781 chr19:47549865 TMEM160 -1.15 -18.25 -0.71 4.26e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1728785 1.000 rs1069288 chr16:68585285 C/G cg02972257 chr16:68554789 NA -0.47 -6.14 -0.32 2.33e-9 Ulcerative colitis; LUSC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg07636037 chr3:49044803 WDR6 1.02 17.86 0.7 1.43e-50 Parkinson's disease; LUSC cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.51 -0.42 5.93e-16 Chronic sinus infection; LUSC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg13319975 chr6:146136371 FBXO30 -0.51 -7.74 -0.39 1.17e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs734999 0.588 rs3748817 chr1:2525665 T/C cg18854424 chr1:2615690 NA 0.51 10.44 0.5 2.83e-22 Ulcerative colitis; LUSC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg21770322 chr7:97807741 LMTK2 0.4 6.98 0.36 1.55e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9902453 0.578 rs8073217 chr17:28164263 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 10.7 0.51 3.55e-23 Coffee consumption (cups per day); LUSC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg05234568 chr11:5960015 NA -0.54 -8.11 -0.41 9.72e-15 DNA methylation (variation); LUSC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg25767906 chr1:53392781 SCP2 0.4 6.78 0.35 5.52e-11 Monocyte count; LUSC cis rs7264396 0.887 rs6120951 chr20:34045191 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.71 -0.34 8.33e-11 Total cholesterol levels; LUSC cis rs2070488 0.775 rs2186457 chr3:38553965 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 11.08 0.52 1.62e-24 Electrocardiographic conduction measures; LUSC cis rs10484885 0.618 rs292241 chr6:90603505 A/G cg13799429 chr6:90582589 CASP8AP2 -0.85 -11.31 -0.53 2.41e-25 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2439831 0.850 rs12441984 chr15:44126285 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.9 8.98 0.44 2e-17 Lung cancer in ever smokers; LUSC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg12463550 chr7:65579703 CRCP -0.46 -6.82 -0.35 4.21e-11 Aortic root size; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg01609171 chr16:127997 MPG 0.66 5.99 0.31 5.49e-9 Cognitive performance; LUSC cis rs208520 1.000 rs72882102 chr6:66983408 C/A cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03352830 chr11:487213 PTDSS2 0.66 8.3 0.41 2.59e-15 Body mass index; LUSC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11890956 chr21:40555474 PSMG1 1.03 20.65 0.75 1.23e-61 Cognitive function; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg03395511 chr6:291903 DUSP22 -0.47 -7.1 -0.36 7.35e-12 Menopause (age at onset); LUSC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.51 -8.74 -0.43 1.16e-16 Prudent dietary pattern; LUSC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs7953249 0.618 rs2650000 chr12:121388962 G/T cg02403541 chr12:121454288 C12orf43 0.71 11.16 0.52 8.71e-25 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs8077889 0.871 rs8065043 chr17:41900984 G/A cg26893861 chr17:41843967 DUSP3 0.88 13.8 0.6 1.38e-34 Triglycerides; LUSC cis rs2404602 0.672 rs35374222 chr15:77071394 G/T cg23625390 chr15:77176239 SCAPER -0.66 -9.97 -0.48 1.16e-20 Blood metabolite levels; LUSC cis rs4285028 0.948 rs34158925 chr3:121678465 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.63 -0.47 1.55e-19 Multiple sclerosis; LUSC cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.24 0.41 4.08e-15 Height; LUSC cis rs977987 0.741 rs10514393 chr16:75344476 C/T cg03315344 chr16:75512273 CHST6 0.52 9.99 0.48 9.79e-21 Dupuytren's disease; LUSC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg01879757 chr17:41196368 BRCA1 -0.54 -8.7 -0.43 1.55e-16 Menopause (age at onset); LUSC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg05234568 chr11:5960015 NA -0.6 -8.66 -0.43 2.01e-16 DNA methylation (variation); LUSC cis rs9811920 0.660 rs11719468 chr3:99671848 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.35 -6.58 -0.34 1.84e-10 Axial length; LUSC cis rs16976116 0.901 rs2899582 chr15:55491734 T/C cg11288833 chr15:55489084 RSL24D1 0.49 5.87 0.31 1.06e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg10883421 chr6:151773342 RMND1;C6orf211 0.67 11.26 0.52 3.93e-25 Menarche (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19565306 chr22:51222011 RPL23AP82;RABL2B -0.43 -6.62 -0.34 1.4e-10 Electrocardiographic conduction measures; LUSC cis rs7799006 0.606 rs2286207 chr7:2303109 G/A cg08027265 chr7:2291960 NA -0.59 -10.54 -0.5 1.3e-22 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.48 -0.33 3.25e-10 Total body bone mineral density; LUSC cis rs7760949 0.889 rs9475816 chr6:13935425 T/C cg27413430 chr6:13925136 RNF182 0.62 9.09 0.45 9.03e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg06808227 chr14:105710500 BRF1 -0.67 -10.02 -0.48 7.94e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs28647808 0.881 rs7042326 chr9:136266636 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC trans rs11039798 0.920 rs11040015 chr11:48783130 G/T cg15704280 chr7:45808275 SEPT13 0.78 7.51 0.38 5.55e-13 Axial length; LUSC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg21951975 chr1:209979733 IRF6 0.55 6.68 0.34 9.75e-11 Coronary artery disease; LUSC cis rs3540 0.513 rs2589974 chr15:90891566 C/T cg22089800 chr15:90895588 ZNF774 -0.63 -10.05 -0.48 6.26e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7833986 1.000 rs34037954 chr8:57096841 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.62 9.2 0.45 3.84e-18 Height; LUSC cis rs7568458 0.870 rs2366639 chr2:85809955 A/G cg17127132 chr2:85788382 GGCX 0.46 7.28 0.37 2.43e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10484885 0.763 rs56401039 chr6:90522486 C/T cg13799429 chr6:90582589 CASP8AP2 -0.85 -7.95 -0.4 2.9e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg04369109 chr6:150039330 LATS1 -0.57 -8.47 -0.42 8.03e-16 Lung cancer; LUSC cis rs13256369 0.802 rs11781257 chr8:8559663 A/T cg18904891 chr8:8559673 CLDN23 0.6 7.87 0.4 4.93e-14 Obesity-related traits; LUSC cis rs9875589 0.509 rs1488379 chr3:14014719 A/G cg19554555 chr3:13937349 NA -0.38 -5.75 -0.3 2e-8 Ovarian reserve; LUSC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg09436375 chr6:42928200 GNMT -0.29 -6.82 -0.35 4.33e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs35883536 0.545 rs56674564 chr1:101097718 T/C cg06223162 chr1:101003688 GPR88 0.34 6.22 0.32 1.51e-9 Monocyte count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03839934 chr5:95997987 CAST 0.72 5.99 0.31 5.54e-9 Cognitive performance; LUSC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg11764359 chr7:65958608 NA 0.53 7.03 0.36 1.14e-11 Aortic root size; LUSC cis rs701145 0.585 rs9839821 chr3:153796323 G/A cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC trans rs61931739 0.500 rs11053167 chr12:34387092 A/C cg13010199 chr12:38710504 ALG10B 0.67 10.59 0.5 8.6e-23 Morning vs. evening chronotype; LUSC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg11764359 chr7:65958608 NA -0.82 -13.78 -0.6 1.69e-34 Aortic root size; LUSC cis rs9283706 0.608 rs1991492 chr5:66328309 A/G cg11590213 chr5:66331682 MAST4 0.47 7.13 0.36 6.3e-12 Coronary artery disease; LUSC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg13798912 chr7:905769 UNC84A -0.59 -5.95 -0.31 6.63e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7582720 1.000 rs72932784 chr2:203698470 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7192380 1.000 rs7191292 chr16:69669427 G/A cg26679644 chr16:69762563 NA 0.34 6.08 0.32 3.25e-9 Sjögren's syndrome; LUSC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg08888203 chr3:10149979 C3orf24 0.65 9.23 0.45 3.31e-18 Alzheimer's disease; LUSC trans rs11039798 0.688 rs10839007 chr11:48703442 A/C cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs35146811 0.735 rs6465766 chr7:99785671 A/G cg13334819 chr7:99746414 C7orf59 -0.49 -6.65 -0.34 1.23e-10 Coronary artery disease; LUSC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg20607798 chr8:58055168 NA 0.53 5.78 0.3 1.73e-8 Developmental language disorder (linguistic errors); LUSC cis rs6430585 0.528 rs6430594 chr2:136719173 C/T cg07169764 chr2:136633963 MCM6 -1.15 -18.77 -0.72 3.45e-54 Corneal structure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07560662 chr1:117113232 CD58 0.45 6.86 0.35 3.39e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs870825 0.616 rs4519834 chr4:185633865 A/G cg04058563 chr4:185651563 MLF1IP -0.85 -13.08 -0.58 7.26e-32 Blood protein levels; LUSC cis rs6964587 1.000 rs12539231 chr7:91634963 G/A cg17063962 chr7:91808500 NA 0.58 9.08 0.44 9.76e-18 Breast cancer; LUSC cis rs1448094 0.935 rs11117119 chr12:86336432 A/T cg18827107 chr12:86230957 RASSF9 -0.4 -5.94 -0.31 7.34e-9 Major depressive disorder; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg04518342 chr5:131593106 PDLIM4 -0.45 -7.66 -0.39 2.05e-13 Blood metabolite levels; LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg01616529 chr11:638424 DRD4 -0.36 -6.08 -0.32 3.2e-9 Systemic lupus erythematosus; LUSC trans rs3942852 0.524 rs7118665 chr11:48078427 C/A cg03929089 chr4:120376271 NA 0.6 7.71 0.39 1.49e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.08 15.3 0.64 2.06e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9527 0.590 rs12775302 chr10:104911356 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.46 -0.33 3.66e-10 Arsenic metabolism; LUSC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg04871131 chr7:94954202 PON1 -0.38 -6.08 -0.32 3.2e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1983891 0.954 rs1886816 chr6:41544494 A/G cg15051332 chr6:41514432 FOXP4 0.41 5.91 0.31 8.43e-9 Prostate cancer; LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg18402987 chr7:1209562 NA 0.7 7.64 0.39 2.35e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6500602 0.592 rs3747585 chr16:4519140 C/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.44 6.38 0.33 5.9e-10 Schizophrenia; LUSC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18404041 chr3:52824283 ITIH1 -0.62 -12.01 -0.55 7.56e-28 Bipolar disorder; LUSC cis rs6494488 0.500 rs72744715 chr15:65016145 G/C cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.71e-8 Coronary artery disease; LUSC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.71 -0.3 2.55e-8 Life satisfaction; LUSC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg09021430 chr5:549028 NA -0.54 -7.07 -0.36 8.97e-12 Lung disease severity in cystic fibrosis; LUSC cis rs7100689 0.646 rs4265545 chr10:82119271 G/T cg01528321 chr10:82214614 TSPAN14 0.87 13.17 0.58 3.37e-32 Post bronchodilator FEV1; LUSC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg14883916 chr11:6947541 ZNF215 0.46 5.96 0.31 6.39e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1595825 1.000 rs73058820 chr2:198864358 A/G cg00982548 chr2:198649783 BOLL -0.51 -6.4 -0.33 5.26e-10 Ulcerative colitis; LUSC cis rs28374715 0.609 rs8043237 chr15:41514298 G/A cg18705301 chr15:41695430 NDUFAF1 -0.84 -14.63 -0.63 8.14e-38 Ulcerative colitis; LUSC cis rs965513 1.000 rs7030241 chr9:100550375 T/A cg13688889 chr9:100608707 NA -0.54 -8.05 -0.4 1.51e-14 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs10089 0.951 rs736969 chr5:127466347 G/C cg19767477 chr5:127420684 SLC12A2 -0.42 -5.65 -0.3 3.46e-8 Ileal carcinoids; LUSC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg03452623 chr4:187889614 NA -0.88 -18.62 -0.71 1.43e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs12618769 0.597 rs4850875 chr2:99069815 A/G cg10123293 chr2:99228465 UNC50 0.46 7.65 0.39 2.13e-13 Bipolar disorder; LUSC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg08499158 chr17:42289980 UBTF 0.54 8.9 0.44 3.67e-17 Total body bone mineral density; LUSC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg26958806 chr6:27640298 NA 0.68 5.75 0.3 2.02e-8 Depression; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg12975862 chr15:48937319 FBN1 0.4 6.0 0.31 5.1e-9 Schizophrenia; LUSC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.53 -7.24 -0.37 3.11e-12 Mean platelet volume; LUSC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg18681998 chr4:17616180 MED28 0.85 16.06 0.66 2.03e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs950169 0.922 rs8037078 chr15:84818871 A/G cg17507749 chr15:85114479 UBE2QP1 -0.67 -8.78 -0.43 8.68e-17 Schizophrenia; LUSC cis rs12220238 1.000 rs11000888 chr10:75901929 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.11 0.36 7.28e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7000551 0.751 rs1482337 chr8:22395509 A/G cg12081754 chr8:22256438 SLC39A14 -0.47 -7.21 -0.37 3.88e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11890956 chr21:40555474 PSMG1 -0.92 -16.56 -0.67 2.2e-45 Cognitive function; LUSC cis rs9905704 0.647 rs11650809 chr17:56972741 A/G cg12560992 chr17:57184187 TRIM37 0.59 9.51 0.46 4e-19 Testicular germ cell tumor; LUSC cis rs7264396 0.563 rs7264869 chr20:34346502 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -7.73 -0.39 1.3e-13 Total cholesterol levels; LUSC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg04287289 chr16:89883240 FANCA 0.78 13.7 0.6 3.27e-34 Vitiligo; LUSC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg02376097 chr19:46275166 DMPK 0.4 6.93 0.35 2.15e-11 Coronary artery disease; LUSC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg18850127 chr7:39170497 POU6F2 -0.64 -10.01 -0.48 8.5e-21 IgG glycosylation; LUSC cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.17 0.58 3.43e-32 Chronic sinus infection; LUSC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg02569458 chr12:86230093 RASSF9 0.57 9.68 0.47 1.05e-19 Major depressive disorder; LUSC trans rs7824557 0.583 rs6601585 chr8:11233659 A/G cg08975724 chr8:8085496 FLJ10661 -0.46 -6.77 -0.35 5.85e-11 Retinal vascular caliber; LUSC cis rs4478858 0.735 rs7556340 chr1:31788453 A/T cg00250761 chr1:31883323 NA -0.34 -8.57 -0.42 3.81e-16 Alcohol dependence; LUSC cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs66716358 0.773 rs7118653 chr11:44327797 T/C cg16977035 chr11:44330474 ALX4 0.35 5.79 0.3 1.61e-8 Monobrow; LUSC cis rs10740039 0.516 rs7072678 chr10:62344769 C/T cg18175470 chr10:62150864 ANK3 0.47 7.08 0.36 8.67e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg08859206 chr1:53392774 SCP2 0.49 8.26 0.41 3.56e-15 Monocyte count; LUSC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg06740227 chr12:86229804 RASSF9 0.39 6.09 0.32 3.05e-9 Major depressive disorder; LUSC cis rs10876993 0.890 rs4760165 chr12:58063801 C/T cg15848620 chr12:58087721 OS9 -0.54 -7.73 -0.39 1.25e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs12220238 0.818 rs115350439 chr10:75899365 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.14 0.36 5.91e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs9527 0.590 rs7089680 chr10:104802071 C/T cg23093090 chr10:104574429 C10orf26 0.36 6.78 0.35 5.36e-11 Arsenic metabolism; LUSC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg08219700 chr8:58056026 NA 0.5 6.18 0.32 1.84e-9 Developmental language disorder (linguistic errors); LUSC cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg01849466 chr14:104193079 ZFYVE21 -0.53 -8.38 -0.42 1.47e-15 Schizophrenia; LUSC cis rs4400599 0.618 rs1194599 chr1:154236452 C/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.9 -0.31 8.93e-9 Platelet distribution width; LUSC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg12560992 chr17:57184187 TRIM37 0.86 15.56 0.65 1.86e-41 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.954 rs2306455 chr4:120421969 G/A cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC cis rs8060686 0.641 rs9923710 chr16:68224018 C/T cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs727505 0.721 rs67817822 chr7:124769572 A/G cg23710748 chr7:124431027 NA -0.39 -7.01 -0.36 1.29e-11 Lewy body disease; LUSC cis rs11105298 0.891 rs3741899 chr12:89933931 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.52 -7.18 -0.37 4.68e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs45509595 0.659 rs390764 chr6:27782535 C/T cg06606381 chr12:133084897 FBRSL1 -0.74 -7.4 -0.38 1.1e-12 Breast cancer; LUSC cis rs8114671 0.967 rs4911472 chr20:33775377 T/A cg07148914 chr20:33460835 GGT7 0.46 6.81 0.35 4.63e-11 Height; LUSC cis rs2625529 0.590 rs12442886 chr15:72473611 T/C cg16672083 chr15:72433130 SENP8 0.46 7.19 0.37 4.29e-12 Red blood cell count; LUSC cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg12432903 chr7:1882776 MAD1L1 0.52 6.32 0.33 8.26e-10 Bipolar disorder; LUSC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg18404041 chr3:52824283 ITIH1 -0.36 -6.13 -0.32 2.54e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.58e-14 Prudent dietary pattern; LUSC cis rs7618501 1.000 rs1049256 chr3:49763338 T/C cg24110177 chr3:50126178 RBM5 0.42 6.74 0.35 6.9e-11 Intelligence (multi-trait analysis); LUSC cis rs7605827 0.930 rs6704723 chr2:15599895 A/G cg19274914 chr2:15703543 NA 0.46 8.8 0.43 7.47e-17 Educational attainment (years of education); LUSC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg19812747 chr11:111475976 SIK2 -0.54 -7.76 -0.39 1.05e-13 Primary sclerosing cholangitis; LUSC cis rs992157 1.000 rs736730 chr2:219120255 C/T cg00012203 chr2:219082015 ARPC2 0.81 13.69 0.6 3.57e-34 Colorectal cancer; LUSC cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg14343924 chr8:8086146 FLJ10661 0.43 6.09 0.32 3.12e-9 Mood instability; LUSC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg13154104 chr2:10443632 HPCAL1 -0.43 -6.08 -0.32 3.23e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg05373962 chr22:49881684 NA -0.44 -10.77 -0.51 2.12e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs710216 0.917 rs710223 chr1:43411038 C/G cg22176566 chr1:43424700 SLC2A1 0.5 6.28 0.32 1.07e-9 Red cell distribution width; LUSC cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.79 0.7 2.73e-50 Chronic sinus infection; LUSC cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg23158103 chr7:148848205 ZNF398 -0.49 -8.01 -0.4 1.98e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs7824557 0.527 rs2572369 chr8:11238597 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -6.0 -0.31 5.14e-9 Retinal vascular caliber; LUSC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg08798685 chr6:27730294 NA -0.69 -6.12 -0.32 2.55e-9 Depression; LUSC cis rs7927771 0.524 rs10769299 chr11:47865160 G/T cg20307385 chr11:47447363 PSMC3 0.46 6.8 0.35 4.78e-11 Subjective well-being; LUSC cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg01191920 chr7:158217561 PTPRN2 -0.59 -12.07 -0.55 4.37e-28 Obesity-related traits; LUSC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.47 -6.27 -0.32 1.1e-9 Blood protein levels; LUSC cis rs7605827 0.930 rs13029846 chr2:15674686 T/C cg19274914 chr2:15703543 NA 0.45 8.55 0.42 4.49e-16 Educational attainment (years of education); LUSC cis rs2204008 0.668 rs1619009 chr12:38120485 G/A cg13010199 chr12:38710504 ALG10B -0.53 -7.94 -0.4 3.11e-14 Bladder cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13472656 chr22:25960710 ADRBK2 0.43 6.43 0.33 4.42e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs34779708 0.771 rs12098283 chr10:35478115 G/T cg04310649 chr10:35416472 CREM -0.39 -6.06 -0.31 3.76e-9 Inflammatory bowel disease;Crohn's disease; LUSC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.8 -0.81 9.79e-78 Height; LUSC cis rs11229555 1.000 rs11229543 chr11:58370698 G/A cg15696309 chr11:58395628 NA -0.69 -9.27 -0.45 2.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg16325326 chr1:53192061 ZYG11B 0.92 18.5 0.71 4.18e-53 Monocyte count; LUSC cis rs6681460 0.966 rs10789215 chr1:67151185 C/T cg02459107 chr1:67143332 SGIP1 -0.48 -8.89 -0.44 3.87e-17 Presence of antiphospholipid antibodies; LUSC cis rs5769707 0.706 rs763128 chr22:50018045 G/A cg05373962 chr22:49881684 NA -0.41 -8.81 -0.43 6.75e-17 Monocyte count;Monocyte percentage of white cells; LUSC cis rs894734 0.535 rs2366144 chr12:54324069 G/T cg17410650 chr12:54324560 NA -0.58 -10.66 -0.5 4.93e-23 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.93 0.31 7.55e-9 Rheumatoid arthritis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08093216 chr19:12944890 RTBDN -0.4 -5.98 -0.31 5.88e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9517320 0.967 rs2274056 chr13:99134839 G/C cg07423050 chr13:99094983 FARP1 0.35 6.64 0.34 1.25e-10 Longevity; LUSC cis rs713587 0.776 rs3731623 chr2:25163783 T/C cg04586622 chr2:25135609 ADCY3 0.28 5.69 0.3 2.8e-8 Body mass index in non-asthmatics; LUSC cis rs7937682 0.889 rs12360825 chr11:111528786 A/T cg19812747 chr11:111475976 SIK2 -0.44 -6.08 -0.32 3.29e-9 Primary sclerosing cholangitis; LUSC trans rs12439619 0.846 rs62011975 chr15:82451554 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.46 -6.11 -0.32 2.81e-9 Intelligence (multi-trait analysis); LUSC cis rs11077998 0.967 rs4789790 chr17:80510789 G/A cg10255544 chr17:80519551 FOXK2 0.38 6.25 0.32 1.23e-9 Reticulocyte fraction of red cells; LUSC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg19346786 chr7:2764209 NA -0.4 -7.01 -0.36 1.34e-11 Height; LUSC cis rs34779708 0.931 rs2384287 chr10:35340559 A/G cg03585969 chr10:35415529 CREM 0.58 8.48 0.42 7.17e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9323205 0.954 rs9672122 chr14:51582391 A/G cg23942311 chr14:51606299 NA -0.42 -8.06 -0.4 1.41e-14 Cancer; LUSC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.26 -0.45 2.58e-18 Gut microbiome composition (summer); LUSC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.4 -6.0 -0.31 5.27e-9 Menarche (age at onset); LUSC cis rs6723226 0.521 rs1991626 chr2:32602450 G/A cg02381751 chr2:32503542 YIPF4 -0.51 -7.57 -0.38 3.57e-13 Intelligence (multi-trait analysis); LUSC cis rs3126085 0.935 rs1858480 chr1:152301735 A/G cg26876637 chr1:152193138 HRNR -0.43 -6.19 -0.32 1.75e-9 Atopic dermatitis; LUSC trans rs3857536 0.776 rs9294687 chr6:66942919 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs925255 0.810 rs1396733 chr2:28642747 A/C cg01273330 chr2:28605224 NA 0.42 6.84 0.35 3.68e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg09033563 chr22:24373618 LOC391322 0.48 6.87 0.35 3.09e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9925964 0.967 rs2032915 chr16:31117413 C/T cg02466173 chr16:30829666 NA 0.34 6.28 0.33 1.04e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1775715 0.737 rs2808078 chr10:32172552 C/T cg04359828 chr10:32216031 ARHGAP12 0.4 6.9 0.35 2.69e-11 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs6598955 0.671 rs17163749 chr1:26568165 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.52 -0.42 5.39e-16 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26949087 chr2:26467503 HADHB;HADHA 0.48 6.89 0.35 2.71e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg06558623 chr16:89946397 TCF25 1.01 10.69 0.51 3.78e-23 Skin colour saturation; LUSC cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg08999081 chr20:33150536 PIGU -0.54 -10.65 -0.5 5.47e-23 Glomerular filtration rate (creatinine); LUSC cis rs477692 1.000 rs548390 chr10:131417427 G/A cg05714579 chr10:131428358 MGMT 0.5 7.46 0.38 7.74e-13 Response to temozolomide; LUSC cis rs55665837 1.000 rs10832254 chr11:14434698 A/G cg05501817 chr11:14380813 RRAS2 -0.41 -6.73 -0.35 7.47e-11 Vitamin D levels; LUSC cis rs3741151 0.687 rs724111 chr11:73238645 G/A cg17517138 chr11:73019481 ARHGEF17 0.96 8.06 0.4 1.35e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg07936489 chr17:37558343 FBXL20 -0.43 -5.89 -0.31 9.32e-9 Glomerular filtration rate (creatinine); LUSC cis rs10186029 0.582 rs10497995 chr2:213995346 G/A cg08319019 chr2:214017104 IKZF2 0.49 7.55 0.38 4.22e-13 Systemic sclerosis; LUSC cis rs10927875 0.632 rs6677321 chr1:16149301 A/C cg22431228 chr1:16359049 CLCNKA 0.34 6.41 0.33 5.1e-10 Dilated cardiomyopathy; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02399652 chr3:169684620 LOC100128164;SEC62 0.47 6.58 0.34 1.81e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs10463316 0.779 rs1810084 chr5:150777048 A/G cg03212797 chr5:150827313 SLC36A1 -0.46 -7.01 -0.36 1.29e-11 Metabolite levels (Pyroglutamine); LUSC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg26755928 chr19:10363173 MRPL4 0.45 6.69 0.34 9.18e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs7824557 0.527 rs2736305 chr8:11237773 T/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.48 -0.38 6.65e-13 Retinal vascular caliber; LUSC trans rs61931739 0.963 rs12307606 chr12:34016365 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.97 -0.4 2.47e-14 Morning vs. evening chronotype; LUSC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.600 rs10888532 chr1:153063407 C/A cg07796016 chr1:152779584 LCE1C -0.38 -5.78 -0.3 1.73e-8 Inflammatory skin disease; LUSC cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg14582100 chr15:45693742 SPATA5L1 -0.49 -8.34 -0.42 1.93e-15 Homoarginine levels; LUSC trans rs61931739 0.929 rs7955240 chr12:34066388 G/A cg26384229 chr12:38710491 ALG10B -0.59 -9.6 -0.47 1.91e-19 Morning vs. evening chronotype; LUSC cis rs1153858 1.000 rs2461702 chr15:45647427 A/G cg26924012 chr15:45694286 SPATA5L1 1.13 20.62 0.75 1.62e-61 Homoarginine levels; LUSC cis rs61931739 0.517 rs7975714 chr12:34055611 T/C cg06521331 chr12:34319734 NA -0.47 -7.63 -0.39 2.42e-13 Morning vs. evening chronotype; LUSC cis rs1371867 0.846 rs1788189 chr8:101249762 G/T cg06636551 chr8:101224915 SPAG1 0.39 7.15 0.36 5.67e-12 Atrioventricular conduction; LUSC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg12463550 chr7:65579703 CRCP -0.42 -5.95 -0.31 6.71e-9 Aortic root size; LUSC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg00033643 chr7:134001901 SLC35B4 0.46 7.17 0.37 4.88e-12 Mean platelet volume; LUSC cis rs7208859 0.623 rs9893422 chr17:29111715 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg05368731 chr17:41323189 NBR1 0.93 16.11 0.66 1.32e-43 Menopause (age at onset); LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T cg25618513 chr4:153456716 FBXW7 -0.35 -6.02 -0.31 4.64e-9 Leprosy; LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg10609677 chr17:41278573 BRCA1;NBR2 0.35 5.68 0.3 2.99e-8 Menopause (age at onset); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg00763096 chr15:63893530 FBXL22 0.41 6.01 0.31 4.81e-9 N-glycan levels; LUSC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg22535103 chr8:58192502 C8orf71 -0.77 -8.07 -0.4 1.26e-14 Developmental language disorder (linguistic errors); LUSC cis rs7617773 0.817 rs6800492 chr3:48323890 G/A cg11946769 chr3:48343235 NME6 0.86 13.94 0.61 3.91e-35 Coronary artery disease; LUSC cis rs9549260 0.620 rs12583418 chr13:41195411 G/A cg21288729 chr13:41239152 FOXO1 0.6 9.16 0.45 5.25e-18 Red blood cell count; LUSC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC trans rs12571093 0.773 rs4142047 chr10:70021255 A/C cg04882175 chr6:131122610 NA -0.54 -6.21 -0.32 1.59e-9 Optic nerve measurement (disc area); LUSC cis rs1348850 0.540 rs6737342 chr2:178419117 G/A cg23306229 chr2:178417860 TTC30B 0.55 5.7 0.3 2.62e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.6 8.25 0.41 3.6e-15 Body mass index (adult); LUSC cis rs3768617 0.510 rs2296294 chr1:183095596 T/C ch.1.3577855R chr1:183094577 LAMC1 0.72 11.1 0.52 1.46e-24 Fuchs's corneal dystrophy; LUSC trans rs7615952 0.546 rs4428131 chr3:125346479 C/T cg07211511 chr3:129823064 LOC729375 -0.53 -6.08 -0.32 3.25e-9 Blood pressure (smoking interaction); LUSC cis rs4842666 0.915 rs11105364 chr12:90069276 T/G cg00757033 chr12:89920650 WDR51B 0.49 7.08 0.36 8.61e-12 Blood pressure; LUSC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.96 0.31 6.27e-9 Menopause (age at onset); LUSC cis rs16976116 0.803 rs7168737 chr15:55501344 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08704250 chr15:31115839 NA 0.52 7.99 0.4 2.24e-14 Huntington's disease progression; LUSC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg09367891 chr1:107599246 PRMT6 -0.56 -8.82 -0.43 6.58e-17 Facial morphology (factor 21, depth of nasal alae); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg20770540 chr3:123304003 PTPLB 0.66 6.18 0.32 1.82e-9 Body mass index; LUSC cis rs4253772 1.000 rs4253772 chr22:46627603 C/T cg18190219 chr22:46762943 CELSR1 -0.52 -6.02 -0.31 4.71e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6489882 0.867 rs4988618 chr12:113363178 G/A cg20102336 chr12:113376681 OAS3 -0.42 -5.93 -0.31 7.36e-9 Chronic lymphocytic leukemia; LUSC trans rs62238980 0.614 rs79110727 chr22:32377455 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs1568889 0.877 rs12786351 chr11:28271122 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.6 6.94 0.35 2.06e-11 Bipolar disorder; LUSC cis rs243505 0.898 rs243542 chr7:148403194 G/A cg09806900 chr7:148480153 CUL1 -0.47 -6.76 -0.35 6.01e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs67460515 0.892 rs35310734 chr3:160943209 T/G cg03342759 chr3:160939853 NMD3 -0.55 -8.11 -0.41 9.81e-15 Parkinson's disease; LUSC cis rs2835872 0.760 rs2835893 chr21:39060893 G/A cg20424643 chr21:39039972 KCNJ6 0.47 7.15 0.36 5.37e-12 Electroencephalographic traits in alcoholism; LUSC cis rs12530845 1.000 rs6975251 chr7:135328689 C/G cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg11632617 chr15:75315747 PPCDC -0.5 -6.58 -0.34 1.86e-10 Blood trace element (Zn levels); LUSC cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg15744005 chr10:104629667 AS3MT -0.32 -6.18 -0.32 1.82e-9 Arsenic metabolism; LUSC cis rs2522056 0.808 rs1016988 chr5:131744574 T/C cg24060327 chr5:131705240 SLC22A5 0.5 6.91 0.35 2.49e-11 Lymphocyte counts;Fibrinogen; LUSC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg24881330 chr22:46731750 TRMU 0.82 7.39 0.37 1.21e-12 LDL cholesterol;Cholesterol, total; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22253313 chr4:2011099 WHSC2 -0.48 -5.97 -0.31 6.04e-9 Bipolar disorder and schizophrenia; LUSC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg23791538 chr6:167370224 RNASET2 0.4 6.46 0.33 3.81e-10 Crohn's disease; LUSC cis rs2439831 1.000 rs2439841 chr15:43734749 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.65 0.43 2.17e-16 Lung cancer in ever smokers; LUSC cis rs9462027 0.561 rs2235568 chr6:34570094 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.15 -0.32 2.19e-9 Systemic lupus erythematosus; LUSC cis rs7267979 0.966 rs2257712 chr20:25264910 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.49 0.75 5.16e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10911232 0.507 rs3935384 chr1:183028970 C/T ch.1.3577855R chr1:183094577 LAMC1 0.74 11.46 0.53 6.99e-26 Hypertriglyceridemia; LUSC cis rs950776 0.518 rs12910289 chr15:78822065 T/G cg22563815 chr15:78856949 CHRNA5 0.27 6.37 0.33 6.43e-10 Sudden cardiac arrest; LUSC cis rs9837602 0.938 rs1017968 chr3:99787011 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.17 0.32 1.97e-9 Breast cancer; LUSC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg13770153 chr20:60521292 NA -0.64 -8.6 -0.43 3.17e-16 Body mass index; LUSC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg13010344 chr12:123464640 ARL6IP4 -0.45 -6.85 -0.35 3.48e-11 Height;Educational attainment;Head circumference (infant); LUSC cis rs754466 0.651 rs10824582 chr10:79603688 T/C cg17075019 chr10:79541650 NA -0.75 -12.05 -0.55 4.99e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7937682 0.575 rs7950926 chr11:111776437 G/C cg09085632 chr11:111637200 PPP2R1B 0.93 13.22 0.59 2.25e-32 Primary sclerosing cholangitis; LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg22166914 chr1:53195759 ZYG11B -0.61 -10.11 -0.48 3.92e-21 Monocyte count; LUSC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg13390004 chr1:15929781 NA 0.41 6.74 0.35 7.15e-11 Systolic blood pressure; LUSC cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg14530993 chr4:882597 GAK 0.8 7.72 0.39 1.4e-13 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00860370 chr1:104068121 RNPC3 -0.43 -6.06 -0.31 3.74e-9 Electrocardiographic conduction measures; LUSC cis rs9457247 1.000 rs10946199 chr6:167404492 G/A cg23791538 chr6:167370224 RNASET2 -0.41 -6.65 -0.34 1.21e-10 Crohn's disease; LUSC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9650657 0.537 rs11250092 chr8:10786543 A/G cg15556689 chr8:8085844 FLJ10661 0.55 8.28 0.41 2.95e-15 Neuroticism; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 15.59 0.65 1.47e-41 Platelet count; LUSC cis rs793571 0.543 rs11854073 chr15:58972995 G/A cg05156742 chr15:59063176 FAM63B 0.52 7.61 0.38 2.82e-13 Schizophrenia; LUSC cis rs1215050 0.904 rs890469 chr4:98923293 T/C cg05340658 chr4:99064831 C4orf37 -0.43 -6.53 -0.34 2.48e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg16339924 chr4:17578868 LAP3 0.57 8.63 0.43 2.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.89 0.31 9.5e-9 Lung cancer; LUSC cis rs9467773 0.967 rs6932865 chr6:26540166 C/A cg05738196 chr6:26577821 NA 0.81 15.89 0.66 9.79e-43 Intelligence (multi-trait analysis); LUSC cis rs3808502 0.527 rs4410870 chr8:11156120 C/G cg21775007 chr8:11205619 TDH -0.48 -7.11 -0.36 7.19e-12 Neuroticism; LUSC trans rs7824557 0.527 rs2409756 chr8:11242025 A/C cg15556689 chr8:8085844 FLJ10661 -0.56 -8.11 -0.41 9.76e-15 Retinal vascular caliber; LUSC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg14019146 chr3:50243930 SLC38A3 0.36 8.27 0.41 3.28e-15 Body mass index; LUSC cis rs9309473 0.687 rs6710659 chr2:73607510 A/G cg20560298 chr2:73613845 ALMS1 -0.58 -8.34 -0.42 1.96e-15 Metabolite levels; LUSC cis rs73206853 0.841 rs56209636 chr12:110841998 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4974559 0.947 rs6847321 chr4:1347374 C/T cg02980000 chr4:1222292 CTBP1 0.72 7.55 0.38 4.26e-13 Systolic blood pressure; LUSC cis rs9420 0.809 rs11600169 chr11:57464945 T/A cg02958346 chr11:57425731 CLP1 -0.43 -6.27 -0.32 1.13e-9 Schizophrenia; LUSC cis rs9308433 0.529 rs9430133 chr1:214496313 C/T cg06198575 chr1:214491504 SMYD2 0.45 7.06 0.36 9.75e-12 IgG glycosylation; LUSC cis rs12579753 0.913 rs12579018 chr12:82231943 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC trans rs11700980 0.551 rs2832011 chr21:30110690 T/C cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs11608355 0.597 rs2304548 chr12:109795166 T/G cg19025524 chr12:109796872 NA -0.48 -9.16 -0.45 5.49e-18 Neuroticism; LUSC trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg03929089 chr4:120376271 NA 0.79 10.87 0.51 8.96e-24 Coronary artery disease; LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg11645453 chr3:52864694 ITIH4 0.29 6.71 0.34 8.27e-11 Electroencephalogram traits; LUSC cis rs11758351 0.925 rs10452600 chr6:26192502 C/A cg06951627 chr6:26196580 NA 0.53 5.72 0.3 2.39e-8 Gout;Renal underexcretion gout; LUSC cis rs6815814 0.950 rs113465719 chr4:38808045 A/T cg02016764 chr4:38805732 TLR1 -0.54 -5.92 -0.31 7.93e-9 Breast cancer; LUSC cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1729951 0.575 rs361241 chr3:136699561 C/A cg12473912 chr3:136751656 NA 0.38 6.78 0.35 5.53e-11 Neuroticism; LUSC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg05347473 chr6:146136440 FBXO30 0.57 10.06 0.48 5.51e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg25319279 chr11:5960081 NA -0.4 -5.92 -0.31 7.97e-9 DNA methylation (variation); LUSC cis rs9611519 1.000 rs9611510 chr22:41569124 T/C cg03806693 chr22:41940476 POLR3H -0.57 -7.94 -0.4 3.2e-14 Neuroticism; LUSC cis rs28647808 0.881 rs28494844 chr9:136266188 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg20503657 chr10:835505 NA 0.78 9.42 0.46 7.61e-19 Eosinophil percentage of granulocytes; LUSC cis rs1775715 0.870 rs1755072 chr10:32266642 A/G cg26784012 chr10:32216390 ARHGAP12 -0.43 -6.97 -0.36 1.7e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs897984 0.762 rs2054213 chr16:30971810 A/G cg02466173 chr16:30829666 NA 0.56 11.38 0.53 1.4e-25 Dementia with Lewy bodies; LUSC cis rs11122272 0.735 rs2486743 chr1:231506928 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.62 -9.69 -0.47 1e-19 Hemoglobin concentration; LUSC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9788682 0.633 rs2656070 chr15:78730252 A/G cg24631222 chr15:78858424 CHRNA5 -0.66 -8.7 -0.43 1.52e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.606 rs4699611 chr4:99097492 T/G cg17366294 chr4:99064904 C4orf37 0.53 9.03 0.44 1.35e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs6426558 0.537 rs2718193 chr1:227404672 C/G cg10327440 chr1:227177885 CDC42BPA 0.54 7.35 0.37 1.55e-12 Neutrophil percentage of white cells; LUSC cis rs2599510 0.729 rs1135484 chr2:32749060 G/A cg02381751 chr2:32503542 YIPF4 0.4 5.82 0.3 1.38e-8 Interleukin-18 levels; LUSC cis rs6987853 0.563 rs10958723 chr8:42448188 T/C cg09913449 chr8:42400586 C8orf40 0.4 6.65 0.34 1.23e-10 Mean corpuscular hemoglobin concentration; LUSC cis rs1524927 1.000 rs11765843 chr7:96341168 T/A cg03808172 chr7:96339361 SHFM1 0.43 6.66 0.34 1.12e-10 Total body bone mineral density; LUSC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg06027949 chr8:82754900 SNX16 -0.43 -5.81 -0.3 1.48e-8 Diastolic blood pressure; LUSC cis rs17685 0.740 rs4732514 chr7:75613998 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.44 6.79 0.35 5.03e-11 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs968451 1.000 rs11704615 chr22:39696834 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.68 9.0 0.44 1.8e-17 Primary biliary cholangitis; LUSC cis rs9677476 0.779 rs72983683 chr2:232100970 G/T cg07929768 chr2:232055508 NA 0.38 6.43 0.33 4.39e-10 Food antigen IgG levels; LUSC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg05855489 chr10:104503620 C10orf26 0.59 9.45 0.46 6.11e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs62283056 0.512 rs10028875 chr4:6283460 C/T cg14416269 chr4:6271139 WFS1 0.44 8.21 0.41 5.02e-15 Cisplatin-induced ototoxicity; LUSC cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg19717773 chr7:2847554 GNA12 -0.33 -5.81 -0.3 1.46e-8 Height; LUSC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.18 0.52 7.44e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg22532475 chr10:104410764 TRIM8 -0.3 -6.9 -0.35 2.62e-11 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg24562669 chr7:97807699 LMTK2 0.35 6.08 0.32 3.26e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg25882455 chr22:38599073 MAFF -0.49 -5.96 -0.31 6.23e-9 Neuroticism; LUSC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg22532475 chr10:104410764 TRIM8 -0.32 -7.14 -0.36 5.8e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg03579872 chr1:53393473 SCP2 0.4 6.1 0.32 3e-9 Monocyte count; LUSC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs11690935 0.918 rs11757 chr2:172641045 C/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.53 -0.62 2.15e-37 Schizophrenia; LUSC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg08219700 chr8:58056026 NA 0.69 7.91 0.4 3.7e-14 Developmental language disorder (linguistic errors); LUSC cis rs6596100 0.500 rs67904956 chr5:132274044 A/G cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Breast cancer; LUSC cis rs7809950 0.953 rs2520267 chr7:107187497 T/C cg23024343 chr7:107201750 COG5 -0.55 -8.73 -0.43 1.25e-16 Coronary artery disease; LUSC trans rs35110281 0.720 rs162400 chr21:44950305 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.51 0.53 4.62e-26 Mean corpuscular volume; LUSC cis rs8044995 0.501 rs55793998 chr16:68378985 G/T cg05110241 chr16:68378359 PRMT7 -0.77 -9.01 -0.44 1.6e-17 Schizophrenia; LUSC cis rs9467773 1.000 rs3736782 chr6:26505403 C/A cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.97e-18 Intelligence (multi-trait analysis); LUSC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg04850211 chr1:228464232 OBSCN -0.33 -5.94 -0.31 7.25e-9 Diastolic blood pressure; LUSC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg12016809 chr21:47604291 C21orf56 0.45 6.91 0.35 2.46e-11 Testicular germ cell tumor; LUSC cis rs3087591 1.000 rs2051507 chr17:29700101 A/G cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.09 -0.4 1.14e-14 Hip circumference; LUSC cis rs3736594 1.000 rs3792252 chr2:27995931 A/G cg27432699 chr2:27873401 GPN1 0.58 7.96 0.4 2.69e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg25456477 chr12:86230367 RASSF9 0.34 5.69 0.3 2.78e-8 Major depressive disorder; LUSC cis rs1728785 1.000 rs864741 chr16:68576577 C/T cg02508848 chr16:68573721 ZFP90 -0.42 -5.75 -0.3 2.07e-8 Ulcerative colitis; LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg27535305 chr1:53392650 SCP2 0.36 6.71 0.34 8.29e-11 Monocyte count; LUSC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC cis rs11098499 0.863 rs2127823 chr4:120485670 G/T cg24375607 chr4:120327624 NA 0.73 10.88 0.51 8.47e-24 Corneal astigmatism; LUSC cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg08807101 chr21:30365312 RNF160 -0.72 -12.8 -0.57 8.5e-31 Dental caries; LUSC cis rs8062405 0.698 rs10499 chr16:28915527 G/A cg05966235 chr16:28915196 ATP2A1 -0.36 -6.07 -0.32 3.53e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg05347473 chr6:146136440 FBXO30 -0.35 -5.67 -0.3 3.05e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.42 -7.76 -0.39 1.05e-13 Monocyte percentage of white cells; LUSC cis rs6542838 0.641 rs6704682 chr2:99499602 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.39 -0.33 5.63e-10 Fear of minor pain; LUSC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg12963246 chr6:28129442 ZNF389 0.37 5.7 0.3 2.57e-8 Cardiac Troponin-T levels; LUSC cis rs9309473 0.528 rs6546820 chr2:73553397 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -7.01 -0.36 1.35e-11 Metabolite levels; LUSC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg19774624 chr17:42201019 HDAC5 0.48 7.2 0.37 4.14e-12 Total body bone mineral density; LUSC cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.74 0.84 1.09e-88 Chronic sinus infection; LUSC cis rs12549902 0.966 rs4317621 chr8:41516581 A/G cg21772509 chr8:41503840 NKX6-3 0.58 9.38 0.46 1.07e-18 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs73198271 0.813 rs17697237 chr8:8615874 A/C cg01851573 chr8:8652454 MFHAS1 -0.52 -8.52 -0.42 5.73e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg06634786 chr22:41940651 POLR3H 0.53 6.19 0.32 1.81e-9 Vitiligo; LUSC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg24562669 chr7:97807699 LMTK2 0.36 6.23 0.32 1.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11676348 0.774 rs57545959 chr2:219047718 A/G cg18102446 chr2:218934044 RUFY4 -0.35 -5.81 -0.3 1.47e-8 Ulcerative colitis; LUSC cis rs2274273 0.840 rs943590 chr14:55738596 T/C cg04306507 chr14:55594613 LGALS3 0.57 13.25 0.59 1.68e-32 Protein biomarker; LUSC cis rs7937682 0.632 rs2070894 chr11:111780837 G/A cg09085632 chr11:111637200 PPP2R1B 0.93 12.62 0.57 3.86e-30 Primary sclerosing cholangitis; LUSC cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg11984989 chr7:158649758 WDR60 1.06 21.05 0.76 3.25e-63 Height; LUSC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg07343612 chr16:622815 PIGQ -0.77 -13.73 -0.6 2.61e-34 Height; LUSC cis rs4964805 0.626 rs11111771 chr12:104179271 A/G cg02344784 chr12:104178138 NT5DC3 -0.42 -6.73 -0.35 7.5e-11 Attention deficit hyperactivity disorder; LUSC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg15744005 chr10:104629667 AS3MT -0.28 -6.11 -0.32 2.76e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs72781680 0.848 rs72798057 chr2:23976731 T/C cg20701182 chr2:24300061 SF3B14 0.57 6.01 0.31 4.88e-9 Lymphocyte counts; LUSC cis rs6121246 0.567 rs6120937 chr20:30219721 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.18 -0.32 1.83e-9 Mean corpuscular hemoglobin; LUSC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg12257692 chr3:49977190 RBM6 0.24 6.65 0.34 1.19e-10 Body mass index; LUSC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg21138405 chr5:131827807 IRF1 0.56 10.98 0.52 3.71e-24 Asthma (sex interaction); LUSC trans rs61931739 0.534 rs10844774 chr12:34166764 C/T cg26384229 chr12:38710491 ALG10B 0.74 11.93 0.55 1.42e-27 Morning vs. evening chronotype; LUSC cis rs6977940 0.512 rs6461600 chr7:2816537 C/T cg19731401 chr7:2775893 GNA12 0.62 8.48 0.42 7.54e-16 White matter integrity; LUSC cis rs7605827 0.930 rs12692263 chr2:15539206 G/A cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs12049330 0.689 rs10494041 chr1:110031990 C/G cg05049280 chr1:110155535 GNAT2 0.4 5.94 0.31 7.14e-9 Major depressive disorder; LUSC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.72 0.65 4.67e-42 Platelet count; LUSC cis rs2859741 0.565 rs12031540 chr1:37513757 C/T cg09363841 chr1:37513479 NA -0.36 -6.89 -0.35 2.82e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs909674 0.731 rs4821897 chr22:39835587 A/G cg24399712 chr22:39784796 NA -0.63 -10.72 -0.51 3.08e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg27170947 chr2:26402098 FAM59B -0.62 -9.1 -0.45 8.44e-18 Gut microbiome composition (summer); LUSC cis rs4789693 0.938 rs8078595 chr17:80426988 G/T cg04308225 chr17:80449738 NA 0.47 7.72 0.39 1.36e-13 Glucocorticoid-induced osteonecrosis; LUSC trans rs2836974 0.613 rs2245455 chr21:40548087 A/T cg18844304 chr19:55851052 SUV420H2 -0.39 -6.18 -0.32 1.88e-9 Cognitive function; LUSC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg08219700 chr8:58056026 NA 0.49 6.11 0.32 2.75e-9 Developmental language disorder (linguistic errors); LUSC cis rs6089584 0.566 rs6061401 chr20:60607482 G/A cg06108461 chr20:60628389 TAF4 -0.71 -11.08 -0.52 1.62e-24 Body mass index; LUSC cis rs3125734 0.633 rs10821968 chr10:63993905 C/T cg19640130 chr10:64028056 RTKN2 0.42 7.38 0.37 1.28e-12 Rheumatoid arthritis; LUSC cis rs7597155 0.967 rs6749078 chr2:69986037 C/G cg02498382 chr2:70120550 SNRNP27 -0.24 -5.77 -0.3 1.81e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg14552801 chr7:65878734 NA -0.46 -6.54 -0.34 2.28e-10 Aortic root size; LUSC cis rs6596100 0.538 rs72799458 chr5:132188063 C/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.05 -0.31 3.88e-9 Breast cancer; LUSC cis rs3096299 0.702 rs2086825 chr16:89471542 C/T cg02187348 chr16:89574699 SPG7 0.37 5.74 0.3 2.16e-8 Multiple myeloma (IgH translocation); LUSC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg21724239 chr8:58056113 NA 0.81 9.61 0.47 1.86e-19 Developmental language disorder (linguistic errors); LUSC cis rs55665837 0.559 rs11023209 chr11:14422600 T/C cg05501817 chr11:14380813 RRAS2 -0.46 -7.26 -0.37 2.69e-12 Vitamin D levels; LUSC cis rs7799006 0.606 rs2286207 chr7:2303109 G/A cg12823233 chr7:2316876 SNX8 -0.43 -7.32 -0.37 1.89e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs317689 0.918 rs610192 chr12:69739941 T/C cg14784868 chr12:69753453 YEATS4 0.59 7.67 0.39 1.86e-13 Response to diuretic therapy; LUSC cis rs7267979 0.780 rs2500413 chr20:25241155 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.25 0.56 9.31e-29 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6541297 0.941 rs6693579 chr1:230282707 T/C cg05784532 chr1:230284198 GALNT2 0.61 7.62 0.38 2.69e-13 Coronary artery disease; LUSC cis rs17685 0.784 rs1637043 chr7:75699099 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.84 -0.39 6.14e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg02228329 chr11:64053129 BAD;GPR137 -0.4 -6.16 -0.32 2.12e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7575217 0.921 rs1192785 chr2:101783573 C/T cg23907051 chr2:101730305 TBC1D8 -0.27 -6.56 -0.34 2.06e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs2281558 0.917 rs3787080 chr20:25232604 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.55 8.18 0.41 6.04e-15 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg11871910 chr12:69753446 YEATS4 0.81 14.38 0.62 8.22e-37 Blood protein levels; LUSC cis rs2625529 0.775 rs4777489 chr15:72430434 C/T cg16672083 chr15:72433130 SENP8 0.52 7.78 0.39 9.17e-14 Red blood cell count; LUSC cis rs12579753 0.917 rs2401002 chr12:82215870 C/T cg21231944 chr12:82153410 PPFIA2 -0.38 -5.77 -0.3 1.77e-8 Resting heart rate; LUSC trans rs61931739 1.000 rs12311881 chr12:34036100 A/G cg13010199 chr12:38710504 ALG10B -0.4 -6.04 -0.31 4.04e-9 Morning vs. evening chronotype; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02361781 chr15:52043731 TMOD2;LYSMD2 -0.41 -6.14 -0.32 2.29e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg18654377 chr3:49208889 KLHDC8B 0.44 5.86 0.31 1.09e-8 Menarche (age at onset); LUSC cis rs2797160 1.000 rs2747717 chr6:126008435 A/G cg05901451 chr6:126070800 HEY2 0.57 8.54 0.42 4.71e-16 Endometrial cancer; LUSC trans rs561341 0.505 rs548298 chr17:30297494 C/A cg27661571 chr11:113659931 NA -0.59 -7.18 -0.37 4.61e-12 Hip circumference adjusted for BMI; LUSC cis rs1577917 0.883 rs2166664 chr6:86596622 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -6.36 -0.33 6.51e-10 Response to antipsychotic treatment; LUSC cis rs7215564 0.908 rs2316059 chr17:78663732 C/T cg09596252 chr17:78655493 RPTOR 0.53 5.85 0.31 1.15e-8 Myopia (pathological); LUSC cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg26384229 chr12:38710491 ALG10B 0.87 15.11 0.64 1.15e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs244731 0.959 rs7724098 chr5:176659570 G/A cg17509989 chr5:176798049 RGS14 -0.68 -9.35 -0.46 1.26e-18 Urate levels in lean individuals; LUSC trans rs60843830 1.000 rs9213 chr2:218386 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.49 0.5 1.98e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 16.09 0.66 1.53e-43 Platelet count; LUSC trans rs9467603 0.925 rs1954598 chr6:25776060 T/C cg06606381 chr12:133084897 FBRSL1 0.59 5.95 0.31 6.9e-9 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg21880101 chr17:80066754 CCDC57 -0.31 -5.89 -0.31 9.22e-9 Life satisfaction; LUSC trans rs1005277 0.522 rs289645 chr10:37943642 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -6.37 -0.33 6.35e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2115630 1.000 rs11073730 chr15:85354596 C/T cg09876464 chr15:85330779 ZNF592 0.36 6.65 0.34 1.17e-10 P wave terminal force; LUSC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg03161606 chr19:29218774 NA 0.65 10.27 0.49 1.12e-21 Methadone dose in opioid dependence; LUSC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs12824058 0.707 rs2398509 chr12:130816464 T/C cg24838063 chr12:130822603 PIWIL1 0.7 10.3 0.49 8.96e-22 Menopause (age at onset); LUSC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.75 0.43 1.09e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg03433033 chr1:76189801 ACADM 0.75 10.36 0.49 5.28e-22 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9677476 0.821 rs6708809 chr2:232112730 A/C cg07929768 chr2:232055508 NA 0.34 6.28 0.32 1.06e-9 Food antigen IgG levels; LUSC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg23982607 chr1:1823379 GNB1 0.53 9.57 0.46 2.57e-19 Body mass index; LUSC cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg21770322 chr7:97807741 LMTK2 -0.36 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg08999081 chr20:33150536 PIGU 0.52 10.41 0.49 3.65e-22 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg22535103 chr8:58192502 C8orf71 -0.63 -7.22 -0.37 3.54e-12 Developmental language disorder (linguistic errors); LUSC cis rs6087771 0.642 rs6060403 chr20:30221104 C/A cg18721089 chr20:30220636 NA -0.34 -5.82 -0.3 1.35e-8 Subcortical brain region volumes;Putamen volume; LUSC cis rs2014572 0.510 rs8111661 chr19:57752326 C/G cg24459738 chr19:57751996 ZNF805 0.51 7.62 0.38 2.71e-13 Hyperactive-impulsive symptoms; LUSC cis rs354225 0.544 rs10169975 chr2:54808159 C/T cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.03 -0.36 1.17e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg02822958 chr2:46747628 ATP6V1E2 0.44 6.38 0.33 5.9e-10 Height; LUSC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00852613 chr13:50159829 RCBTB1 -0.48 -6.46 -0.33 3.72e-10 Bipolar disorder and schizophrenia; LUSC cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.56 7.6 0.38 3.06e-13 Glomerular filtration rate in chronic kidney disease; LUSC cis rs11048434 0.761 rs12827055 chr12:9130861 G/T cg13575925 chr12:9217583 LOC144571 0.34 6.18 0.32 1.92e-9 Sjögren's syndrome; LUSC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg00166722 chr3:10149974 C3orf24 0.6 8.41 0.42 1.19e-15 Alzheimer's disease; LUSC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -9.46 -0.46 5.75e-19 Monocyte percentage of white cells; LUSC trans rs2262909 0.962 rs11669110 chr19:22296485 A/G cg05197062 chr11:11642011 GALNTL4 0.55 7.68 0.39 1.83e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7312933 0.531 rs2406674 chr12:42720150 T/C cg01256987 chr12:42539512 GXYLT1 0.35 6.4 0.33 5.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg09455208 chr3:40491958 NA 0.52 9.16 0.45 5.22e-18 Renal cell carcinoma; LUSC cis rs10465746 0.935 rs35946036 chr1:84438991 A/G cg10977910 chr1:84465055 TTLL7 0.42 6.23 0.32 1.42e-9 Obesity-related traits; LUSC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg11764359 chr7:65958608 NA -0.55 -7.26 -0.37 2.79e-12 Aortic root size; LUSC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg00074818 chr8:8560427 CLDN23 0.57 9.71 0.47 8.22e-20 Obesity-related traits; LUSC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg11941060 chr3:133502564 NA -0.46 -6.66 -0.34 1.12e-10 Iron status biomarkers; LUSC cis rs7084402 1.000 rs12257983 chr10:60266555 A/C cg07615347 chr10:60278583 BICC1 -0.35 -5.76 -0.3 1.95e-8 Refractive error; LUSC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.61 9.46 0.46 5.83e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg19717773 chr7:2847554 GNA12 -0.37 -6.62 -0.34 1.43e-10 Height; LUSC cis rs1982963 0.627 rs61971554 chr14:52491583 A/G cg10843707 chr14:52510701 NID2 0.46 6.23 0.32 1.4e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg11344533 chr11:111475393 SIK2 -0.46 -6.35 -0.33 7.19e-10 Primary sclerosing cholangitis; LUSC cis rs644799 0.710 rs10831433 chr11:95519787 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.87 13.63 0.6 6.14e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9660992 0.700 rs1172125 chr1:205258442 A/T cg21545522 chr1:205238299 TMCC2 0.45 8.43 0.42 1.08e-15 Mean corpuscular volume;Mean platelet volume; LUSC cis rs10782582 0.593 rs12132750 chr1:76136222 A/G cg03433033 chr1:76189801 ACADM -0.46 -7.0 -0.36 1.37e-11 Daytime sleep phenotypes; LUSC cis rs17685 0.712 rs7785025 chr7:75628101 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.77 0.39 9.91e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.5 -8.09 -0.4 1.14e-14 Bipolar disorder; LUSC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg03517284 chr6:25882590 NA 0.63 11.04 0.52 2.3e-24 Blood metabolite levels; LUSC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg14196790 chr5:131705035 SLC22A5 0.45 7.73 0.39 1.27e-13 Perceived unattractiveness to mosquitoes; LUSC cis rs2540226 0.935 rs3732122 chr2:39988703 T/C cg23576258 chr2:39999331 THUMPD2 0.35 5.81 0.3 1.47e-8 Personality dimensions; LUSC cis rs9314323 0.767 rs6557915 chr8:26209062 C/A cg13160058 chr8:26243215 BNIP3L -0.4 -6.98 -0.36 1.63e-11 Red cell distribution width; LUSC cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg16339924 chr4:17578868 LAP3 0.64 9.6 0.47 1.92e-19 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC trans rs17685 0.712 rs1859794 chr7:75821544 G/A cg19862616 chr7:65841803 NCRNA00174 1.08 17.88 0.7 1.23e-50 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7647973 0.626 rs62260720 chr3:49853796 T/A cg13072238 chr3:49761600 GMPPB 0.68 8.73 0.43 1.23e-16 Menarche (age at onset); LUSC cis rs17270561 0.562 rs12199626 chr6:26013604 G/A cg17691542 chr6:26056736 HIST1H1C 1.0 12.67 0.57 2.59e-30 Iron status biomarkers; LUSC trans rs11098499 0.863 rs9884402 chr4:120489982 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.97 0.4 2.55e-14 Corneal astigmatism; LUSC cis rs7107174 0.792 rs2888465 chr11:77945807 T/C cg02023728 chr11:77925099 USP35 0.51 7.08 0.36 8.52e-12 Testicular germ cell tumor; LUSC cis rs11997175 0.646 rs66856932 chr8:33700782 A/G ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.2e-10 Body mass index; LUSC cis rs9393777 0.720 rs57713596 chr6:27004098 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.54 -6.43 -0.33 4.47e-10 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.740 rs13418586 chr2:238445593 A/G cg14458575 chr2:238380390 NA 0.49 8.63 0.43 2.48e-16 Prostate cancer; LUSC cis rs4917300 0.605 rs7820768 chr8:143110823 C/T cg25363559 chr8:143086065 NA -0.29 -6.51 -0.34 2.76e-10 Amyotrophic lateral sclerosis; LUSC cis rs9467773 0.967 rs7753565 chr6:26560012 A/G cg11502198 chr6:26597334 ABT1 0.63 9.98 0.48 1.07e-20 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg27584171 chr15:49338887 SECISBP2L 0.8 6.22 0.32 1.46e-9 Cognitive performance; LUSC cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg09035930 chr12:129282057 SLC15A4 0.73 15.62 0.65 1.14e-41 Systemic lupus erythematosus; LUSC cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg05347473 chr6:146136440 FBXO30 -0.48 -8.04 -0.4 1.55e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg21017887 chr14:105400489 NA -0.71 -13.59 -0.6 8.35e-34 Rheumatoid arthritis; LUSC cis rs2346177 0.519 rs4563285 chr2:46669944 C/G cg02822958 chr2:46747628 ATP6V1E2 0.47 8.42 0.42 1.14e-15 HDL cholesterol; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg14159672 chr1:205819179 PM20D1 0.98 21.18 0.76 9.77e-64 Menarche (age at onset); LUSC cis rs17373728 0.526 rs10957753 chr8:76133428 T/C cg07016329 chr8:76221503 NA 0.43 6.07 0.31 3.57e-9 Diabetic kidney disease; LUSC cis rs193541 0.626 rs6884058 chr5:122087298 T/C cg19077854 chr5:122220652 SNX24 0.28 6.21 0.32 1.59e-9 Glucose homeostasis traits; LUSC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg25072359 chr17:41440525 NA 0.66 9.42 0.46 7.64e-19 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21143892 chr7:132937713 EXOC4 -0.45 -6.49 -0.33 3.06e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg03433033 chr1:76189801 ACADM -0.72 -9.64 -0.47 1.43e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11098499 0.615 rs28850368 chr4:120554313 G/A cg24375607 chr4:120327624 NA 0.72 11.49 0.53 5.61e-26 Corneal astigmatism; LUSC cis rs4363385 0.818 rs3181787 chr1:153004809 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.81 -0.3 1.47e-8 Inflammatory skin disease; LUSC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.82 0.39 7.02e-14 Hip circumference adjusted for BMI; LUSC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg22800045 chr5:56110881 MAP3K1 -0.63 -8.81 -0.43 7.02e-17 Initial pursuit acceleration; LUSC trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -13.69 -0.6 3.44e-34 Coronary artery disease; LUSC cis rs870825 0.615 rs2696038 chr4:185610903 C/T cg04058563 chr4:185651563 MLF1IP -0.79 -12.05 -0.55 4.98e-28 Blood protein levels; LUSC cis rs11585357 0.895 rs72633812 chr1:17623140 T/C cg08277548 chr1:17600880 PADI3 -0.6 -6.26 -0.32 1.17e-9 Hair shape; LUSC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg17366294 chr4:99064904 C4orf37 0.58 10.21 0.49 1.83e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs4285028 0.948 rs79103597 chr3:121667629 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.61 -0.47 1.89e-19 Multiple sclerosis; LUSC cis rs4363385 0.643 rs12734348 chr1:152924650 A/G cg00922841 chr1:152955080 SPRR1A -0.39 -6.56 -0.34 1.99e-10 Inflammatory skin disease; LUSC cis rs62432291 0.614 rs370434 chr6:159654551 C/G cg14500486 chr6:159655392 FNDC1 -0.52 -5.84 -0.3 1.22e-8 Joint mobility (Beighton score); LUSC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg15704280 chr7:45808275 SEPT13 -0.53 -7.51 -0.38 5.47e-13 HDL cholesterol; LUSC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg08847533 chr14:75593920 NEK9 0.85 15.88 0.66 1.08e-42 Height; LUSC cis rs4888262 0.545 rs7195499 chr16:74693973 C/G cg01733217 chr16:74700730 RFWD3 0.8 13.24 0.59 1.94e-32 Testicular germ cell tumor; LUSC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 2.02e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.3 0.69 2.6e-48 Chronic sinus infection; LUSC trans rs1814175 0.500 rs1825677 chr11:49233099 T/G cg21153622 chr11:89784906 NA -0.47 -7.25 -0.37 3.01e-12 Height; LUSC cis rs13006833 0.668 rs2136569 chr2:191167414 C/T cg21644426 chr2:191273491 MFSD6 -0.45 -6.49 -0.33 3.05e-10 Urinary metabolites; LUSC cis rs7923609 0.934 rs10761763 chr10:65188318 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6121246 0.529 rs6060296 chr20:30198480 T/C cg13852791 chr20:30311386 BCL2L1 0.72 8.29 0.41 2.73e-15 Mean corpuscular hemoglobin; LUSC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg08219700 chr8:58056026 NA 0.46 6.12 0.32 2.59e-9 Developmental language disorder (linguistic errors); LUSC cis rs4474465 0.920 rs9804428 chr11:78158948 G/A cg27205649 chr11:78285834 NARS2 -0.49 -5.85 -0.3 1.18e-8 Alzheimer's disease (survival time); LUSC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg17264618 chr3:40429014 ENTPD3 0.3 6.29 0.33 9.8e-10 Renal cell carcinoma; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg10729496 chr3:10149963 C3orf24 0.58 7.75 0.39 1.13e-13 Alzheimer's disease; LUSC cis rs11098499 0.954 rs11940028 chr4:120411907 T/C cg24375607 chr4:120327624 NA 0.79 12.05 0.55 5.19e-28 Corneal astigmatism; LUSC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg20384732 chr3:195601375 TNK2 0.37 5.96 0.31 6.51e-9 Bronchopulmonary dysplasia; LUSC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg08470875 chr2:26401718 FAM59B -0.7 -9.1 -0.45 8.49e-18 Gut microbiome composition (summer); LUSC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg00933542 chr6:150070202 PCMT1 -0.33 -6.74 -0.35 6.92e-11 Lung cancer; LUSC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg07701084 chr6:150067640 NUP43 0.55 8.57 0.42 3.99e-16 Lung cancer; LUSC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg05805236 chr11:65401703 PCNXL3 -0.38 -5.75 -0.3 2.05e-8 Breast cancer; LUSC trans rs1325195 0.920 rs2171959 chr1:179087934 T/C cg11624085 chr17:8464688 MYH10 -0.44 -7.38 -0.37 1.25e-12 IgE grass sensitization; LUSC cis rs9300255 0.537 rs2682429 chr12:123642955 C/G cg05973401 chr12:123451056 ABCB9 0.54 6.64 0.34 1.24e-10 Neutrophil percentage of white cells; LUSC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg18230493 chr5:56204884 C5orf35 -0.65 -9.6 -0.47 1.94e-19 Type 2 diabetes; LUSC cis rs4400599 0.600 rs12095767 chr1:154188028 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.93 -0.31 7.48e-9 Platelet distribution width; LUSC cis rs9560113 1.000 rs9560113 chr13:112183348 A/G cg14154082 chr13:112174009 NA 0.38 7.84 0.39 6.29e-14 Menarche (age at onset); LUSC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.22 0.45 3.32e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2688608 0.901 rs2633312 chr10:75631755 T/A cg23231163 chr10:75533350 FUT11 -0.41 -6.43 -0.33 4.45e-10 Inflammatory bowel disease; LUSC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg06627628 chr2:24431161 ITSN2 0.61 7.38 0.37 1.3e-12 Lymphocyte counts; LUSC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg02569458 chr12:86230093 RASSF9 0.58 9.78 0.47 4.91e-20 Major depressive disorder; LUSC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 13.57 0.6 1.05e-33 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7786808 0.712 rs2335170 chr7:158207101 G/A cg01191920 chr7:158217561 PTPRN2 -0.51 -10.6 -0.5 8.05e-23 Obesity-related traits; LUSC cis rs12956009 0.518 rs3889651 chr18:44865012 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 6.62 0.34 1.41e-10 Educational attainment (years of education); LUSC cis rs4947962 0.555 rs2538079 chr7:54986656 A/G cg23757825 chr7:55092271 EGFR 0.63 7.67 0.39 1.95e-13 Subjective response to lithium treatment; LUSC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.64 -0.73 1.22e-57 Height; LUSC cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg16989719 chr2:238392110 NA -0.38 -6.23 -0.32 1.42e-9 Prostate cancer; LUSC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg26408565 chr15:76604113 ETFA -0.49 -7.86 -0.4 5.27e-14 Blood metabolite levels; LUSC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.09e-11 Blood metabolite levels; LUSC cis rs6570726 1.000 rs1935617 chr6:145943326 C/T cg23711669 chr6:146136114 FBXO30 0.71 11.86 0.54 2.48e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs3947 0.950 rs1293331 chr8:11698436 C/T cg00262122 chr8:11665843 FDFT1 -0.5 -5.82 -0.3 1.4e-8 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg22585957 chr12:8234808 NECAP1 -0.41 -6.47 -0.33 3.47e-10 Electrocardiographic conduction measures; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21939482 chr7:6388130 C7orf70 0.45 6.2 0.32 1.71e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg12307764 chr15:40861449 RPUSD2 0.36 6.35 0.33 7.2e-10 Tuberculosis; LUSC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg00129232 chr17:37814104 STARD3 -0.54 -7.99 -0.4 2.22e-14 Asthma; LUSC cis rs362272 0.524 rs881816 chr4:3365366 A/G cg14583973 chr4:3374767 RGS12 0.37 7.84 0.39 5.95e-14 Serum sulfate level; LUSC cis rs2985684 1.000 rs2147712 chr14:50091684 G/A cg04989706 chr14:50066350 PPIL5 -0.44 -5.77 -0.3 1.85e-8 Carotid intima media thickness; LUSC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg18827107 chr12:86230957 RASSF9 0.49 7.32 0.37 1.87e-12 Major depressive disorder; LUSC cis rs9814567 1.000 rs1814336 chr3:134200823 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -13.69 -0.6 3.72e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7264396 0.635 rs6060656 chr20:34466382 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -8.06 -0.4 1.35e-14 Total cholesterol levels; LUSC cis rs59104589 0.570 rs3771569 chr2:242382606 A/T cg14842376 chr2:242211374 HDLBP 0.5 5.77 0.3 1.79e-8 Fibrinogen levels; LUSC trans rs1814175 0.817 rs28544182 chr11:50049577 G/T cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC trans rs11098499 0.954 rs28572238 chr4:120316686 T/G cg25214090 chr10:38739885 LOC399744 0.53 7.68 0.39 1.73e-13 Corneal astigmatism; LUSC cis rs6961069 0.550 rs34493313 chr7:80246150 T/C cg04458919 chr7:80252533 CD36 -0.39 -6.9 -0.35 2.58e-11 Platelet count; LUSC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg11764359 chr7:65958608 NA -0.78 -12.94 -0.58 2.43e-31 Aortic root size; LUSC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg01483505 chr11:975446 AP2A2 0.41 5.66 0.3 3.29e-8 Alzheimer's disease (late onset); LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg05165339 chr4:1420672 NA 0.28 6.47 0.33 3.53e-10 Obesity-related traits; LUSC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg06740227 chr12:86229804 RASSF9 0.45 7.24 0.37 3.17e-12 Major depressive disorder; LUSC cis rs2361718 0.568 rs1042397 chr17:78092063 G/A cg27427491 chr17:78079615 GAA -0.32 -5.98 -0.31 5.69e-9 Yeast infection; LUSC trans rs208520 0.690 rs851465 chr6:66840293 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -16.94 -0.68 6.8e-47 Exhaled nitric oxide output; LUSC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg07701084 chr6:150067640 NUP43 0.58 9.02 0.44 1.46e-17 Lung cancer; LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs1348850 0.747 rs1047884 chr2:178488281 C/G cg22681709 chr2:178499509 PDE11A -0.52 -9.65 -0.47 1.35e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7188861 0.681 rs66718203 chr16:11428643 C/G cg00044050 chr16:11439710 C16orf75 0.59 5.92 0.31 8.11e-9 HDL cholesterol; LUSC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg18230493 chr5:56204884 C5orf35 0.77 12.51 0.56 1.06e-29 Initial pursuit acceleration; LUSC cis rs1808579 0.904 rs12457261 chr18:21146085 C/T cg14672496 chr18:21087552 C18orf8 0.35 6.19 0.32 1.74e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC trans rs7829975 0.714 rs11777085 chr8:8672429 G/C cg27411982 chr8:10470053 RP1L1 0.41 6.37 0.33 6.17e-10 Mood instability; LUSC cis rs3126085 0.935 rs1496049 chr1:152161949 C/T cg26876637 chr1:152193138 HRNR -0.43 -5.81 -0.3 1.48e-8 Atopic dermatitis; LUSC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.89e-12 Blood metabolite levels; LUSC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.98 -0.31 5.62e-9 Neutrophil percentage of white cells; LUSC cis rs2370759 1.000 rs76998371 chr10:32631785 A/G cg01819863 chr10:32635814 EPC1 1.05 12.84 0.57 6.06e-31 Sexual dysfunction (female); LUSC cis rs1865760 0.622 rs9968910 chr6:26072095 A/C cg16482183 chr6:26056742 HIST1H1C 0.65 9.37 0.46 1.15e-18 Height; LUSC trans rs9291683 0.655 rs55941493 chr4:10100341 G/A cg26043149 chr18:55253948 FECH -0.54 -8.06 -0.4 1.41e-14 Bone mineral density; LUSC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 7.54 0.38 4.61e-13 Reticulocyte count; LUSC cis rs9925964 0.933 rs56314408 chr16:31117389 T/C cg02466173 chr16:30829666 NA -0.32 -5.95 -0.31 6.78e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg05425664 chr17:57184151 TRIM37 -0.54 -8.13 -0.41 8.36e-15 Intelligence (multi-trait analysis); LUSC trans rs459571 1.000 rs2810489 chr9:136922700 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.44 -6.66 -0.34 1.15e-10 Platelet distribution width; LUSC cis rs2879627 0.504 rs6480585 chr10:53673192 A/C cg06976598 chr10:53639124 PRKG1 -0.43 -5.79 -0.3 1.63e-8 Coronary artery disease; LUSC trans rs7916697 0.593 rs3740587 chr10:70020802 G/A cg04882175 chr6:131122610 NA 0.46 6.08 0.32 3.21e-9 Optic disc area; LUSC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg27165867 chr14:105738592 BRF1 0.52 7.72 0.39 1.33e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg06784218 chr1:46089804 CCDC17 -0.48 -9.38 -0.46 1.02e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg14019146 chr3:50243930 SLC38A3 0.35 7.79 0.39 8.56e-14 Body mass index; LUSC cis rs12413816 0.963 rs12359348 chr10:13765950 C/T cg16485048 chr10:13749193 FRMD4A -0.46 -7.67 -0.39 1.86e-13 Red cell distribution width; LUSC cis rs1577917 0.958 rs12198061 chr6:86550985 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.83 -0.35 4.14e-11 Response to antipsychotic treatment; LUSC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.69 0.3 2.75e-8 Cerebrospinal P-tau181p levels; LUSC cis rs1172822 0.698 rs10425848 chr19:55834448 C/G cg04391588 chr19:55832610 TMEM150B 0.3 5.91 0.31 8.49e-9 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs4919687 0.550 rs12761195 chr10:104465374 T/C cg04362960 chr10:104952993 NT5C2 0.47 6.84 0.35 3.68e-11 Colorectal cancer; LUSC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.99 0.55 8.84e-28 Personality dimensions; LUSC cis rs983392 0.679 rs72920867 chr11:60005424 T/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.75 -0.3 1.98e-8 Alzheimer's disease (late onset); LUSC cis rs727505 1.000 rs12111865 chr7:124498035 G/A cg23710748 chr7:124431027 NA -0.4 -7.18 -0.37 4.56e-12 Lewy body disease; LUSC cis rs2637266 1.000 rs1907298 chr10:78329928 A/T cg18941641 chr10:78392320 NA 0.38 6.86 0.35 3.37e-11 Pulmonary function; LUSC trans rs17607347 0.542 rs16971114 chr16:72667858 T/C cg12945194 chr11:64703312 GPHA2 0.37 5.99 0.31 5.53e-9 Intelligence (multi-trait analysis); LUSC cis rs8018967 1.000 rs8018967 chr14:73976934 A/G cg19682024 chr14:74008259 HEATR4;ACOT1 -0.43 -6.01 -0.31 4.81e-9 Blood metabolite ratios; LUSC cis rs6918586 0.658 rs198829 chr6:26118893 A/G cg17691542 chr6:26056736 HIST1H1C 0.4 5.94 0.31 7.21e-9 Schizophrenia; LUSC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg27398817 chr8:82754497 SNX16 0.44 5.95 0.31 6.79e-9 Diastolic blood pressure; LUSC cis rs7119 0.717 rs12916515 chr15:77818518 G/T cg27398640 chr15:77910606 LINGO1 -0.32 -6.92 -0.35 2.29e-11 Type 2 diabetes; LUSC cis rs3858526 0.834 rs7125244 chr11:5980359 T/C cg02574844 chr11:5959923 NA -0.46 -6.45 -0.33 4.02e-10 DNA methylation (variation); LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg08258788 chr8:109455865 TTC35 0.52 6.92 0.35 2.26e-11 Neuroticism; LUSC cis rs1322512 1.000 rs2758784 chr6:153010489 A/G cg27316956 chr6:152958899 SYNE1 0.35 6.06 0.31 3.59e-9 Tonometry; LUSC cis rs7580658 0.963 rs12463451 chr2:128053883 C/T cg09760422 chr2:128146352 NA -0.33 -7.27 -0.37 2.51e-12 Protein C levels; LUSC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg08773314 chr2:239334832 ASB1 0.43 9.34 0.46 1.42e-18 Multiple system atrophy; LUSC trans rs7937682 0.883 rs11213941 chr11:111434094 T/C cg18187862 chr3:45730750 SACM1L -0.53 -6.69 -0.34 9.31e-11 Primary sclerosing cholangitis; LUSC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg00745463 chr17:30367425 LRRC37B -0.74 -8.91 -0.44 3.32e-17 Hip circumference adjusted for BMI; LUSC trans rs11039798 0.582 rs60764175 chr11:48775856 T/G cg03929089 chr4:120376271 NA 0.66 7.36 0.37 1.42e-12 Axial length; LUSC cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg21545522 chr1:205238299 TMCC2 0.51 9.57 0.46 2.54e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg12963246 chr6:28129442 ZNF389 -0.44 -6.35 -0.33 6.87e-10 Depression; LUSC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg11812906 chr14:75593930 NEK9 -0.62 -10.08 -0.48 5.03e-21 Height; LUSC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 7.83 0.39 6.49e-14 Age-related macular degeneration (geographic atrophy); LUSC cis rs13191362 0.507 rs2849534 chr6:163144657 T/A cg18825119 chr6:163149453 PACRG;PARK2 -0.38 -6.73 -0.35 7.56e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13385 0.769 rs7705090 chr5:139618146 C/G cg26211634 chr5:139558579 C5orf32 0.46 6.74 0.35 7.11e-11 Atrial fibrillation; LUSC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.1 16.96 0.68 5.39e-47 Age-related macular degeneration (geographic atrophy); LUSC cis rs11209002 0.956 rs10749772 chr1:67586231 A/G cg02640540 chr1:67518911 SLC35D1 0.67 7.34 0.37 1.69e-12 Crohn's disease; LUSC cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.97 -16.77 -0.68 3.3e-46 Cognitive ability; LUSC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg07716408 chr11:68623521 NA -0.32 -6.09 -0.32 3.16e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs35110281 0.627 rs1836855 chr21:44965414 C/G cg01579765 chr21:45077557 HSF2BP -0.49 -10.31 -0.49 7.85e-22 Mean corpuscular volume; LUSC cis rs16910800 0.689 rs56101126 chr11:23188861 T/A cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg26338869 chr17:61819248 STRADA 0.41 5.8 0.3 1.52e-8 Prudent dietary pattern; LUSC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.52 0.34 2.54e-10 Schizophrenia; LUSC cis rs12210905 0.610 rs12204953 chr6:27396737 G/A cg08851530 chr6:28072375 NA 0.93 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI; LUSC cis rs28647808 1.000 rs28591209 chr9:136259668 T/C cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11644478 chr21:40555479 PSMG1 -0.62 -9.62 -0.47 1.74e-19 Menarche (age at onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22963414 chr14:73493969 ZFYVE1 -0.5 -6.6 -0.34 1.65e-10 Hepatitis; LUSC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs796825 0.512 rs34964758 chr3:119942440 A/C cg21790991 chr3:120137480 FSTL1 -0.33 -5.83 -0.3 1.32e-8 HIV-1 susceptibility; LUSC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg05623727 chr3:50126028 RBM5 0.37 6.89 0.35 2.86e-11 Body mass index; LUSC cis rs6964587 0.967 rs10248102 chr7:91699779 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.5e-8 Breast cancer; LUSC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg04352962 chr1:209979756 IRF6 0.55 6.46 0.33 3.73e-10 Cleft lip with or without cleft palate; LUSC cis rs4631830 0.747 rs745180 chr10:51504493 A/C cg10326726 chr10:51549505 MSMB 0.34 5.94 0.31 7.09e-9 Prostate-specific antigen levels; LUSC cis rs28719689 0.541 rs28376074 chr8:1274394 A/T cg22761795 chr8:1265118 NA 0.56 6.48 0.33 3.27e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg22963979 chr7:1858916 MAD1L1 -0.58 -8.9 -0.44 3.65e-17 Bipolar disorder and schizophrenia; LUSC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.36 0.42 1.68e-15 Age-related macular degeneration (geographic atrophy); LUSC trans rs12579753 1.000 rs34031374 chr12:82235615 G/C cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg05347473 chr6:146136440 FBXO30 -0.59 -10.26 -0.49 1.22e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs950169 0.580 rs11635597 chr15:85165699 C/T cg11189052 chr15:85197271 WDR73 0.5 6.33 0.33 7.89e-10 Schizophrenia; LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg27170947 chr2:26402098 FAM59B -0.7 -10.84 -0.51 1.17e-23 Gut microbiome composition (summer); LUSC cis rs9393777 0.623 rs9358947 chr6:26479000 G/A cg12826209 chr6:26865740 GUSBL1 0.68 7.67 0.39 1.85e-13 Intelligence (multi-trait analysis); LUSC cis rs9811920 0.809 rs4928150 chr3:99685991 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.34 -5.76 -0.3 1.95e-8 Axial length; LUSC trans rs11098499 0.909 rs28632018 chr4:120386730 T/C cg25214090 chr10:38739885 LOC399744 0.57 8.37 0.42 1.56e-15 Corneal astigmatism; LUSC cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg06026331 chr20:60912101 LAMA5 0.6 7.28 0.37 2.37e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs9549260 0.848 rs966968 chr13:41248037 C/T cg21288729 chr13:41239152 FOXO1 -0.6 -9.11 -0.45 7.62e-18 Red blood cell count; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00573086 chr4:2010926 WHSC2 0.38 6.03 0.31 4.25e-9 Asthma; LUSC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs317689 0.684 rs315125 chr12:69758884 C/T cg14784868 chr12:69753453 YEATS4 0.61 8.0 0.4 2.1e-14 Response to diuretic therapy; LUSC cis rs2486288 0.656 rs2413768 chr15:45561984 A/G cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.07e-14 Glomerular filtration rate; LUSC trans rs2727020 0.595 rs10769583 chr11:49483193 G/A cg03929089 chr4:120376271 NA -0.99 -17.59 -0.69 1.74e-49 Coronary artery disease; LUSC cis rs6460942 0.908 rs75704904 chr7:12233583 G/A cg06484146 chr7:12443880 VWDE -0.58 -6.09 -0.32 3.08e-9 Coronary artery disease; LUSC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg17279839 chr7:150038598 RARRES2 0.43 6.65 0.34 1.22e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs1801251 0.778 rs2675957 chr2:233754364 C/T cg08000102 chr2:233561755 GIGYF2 -0.5 -7.66 -0.39 2.03e-13 Coronary artery disease; LUSC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg09796270 chr17:17721594 SREBF1 -0.4 -7.16 -0.36 5.2e-12 Total body bone mineral density; LUSC cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.38 -5.65 -0.3 3.41e-8 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg01181863 chr3:195395398 SDHAP2 -0.53 -5.81 -0.3 1.48e-8 Lung disease severity in cystic fibrosis; LUSC cis rs7923609 1.000 rs4379723 chr10:64963449 T/C cg01631684 chr10:65280961 REEP3 -0.4 -6.26 -0.32 1.19e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7824557 0.614 rs2736286 chr8:11227104 A/G cg21293242 chr8:11204541 TDH -0.3 -5.84 -0.3 1.25e-8 Retinal vascular caliber; LUSC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg04998671 chr14:104000505 TRMT61A -0.42 -5.95 -0.31 6.69e-9 Reticulocyte count; LUSC cis rs7124681 0.584 rs1471712 chr11:47912150 G/A cg20307385 chr11:47447363 PSMC3 -0.52 -7.93 -0.4 3.3e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.94 0.44 2.61e-17 Prudent dietary pattern; LUSC cis rs11971779 0.648 rs9642121 chr7:139092621 G/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs2230307 0.536 rs11166407 chr1:100637708 C/T cg24955406 chr1:100503596 HIAT1 0.57 6.23 0.32 1.4e-9 Carotid intima media thickness; LUSC cis rs6840360 1.000 rs2007218 chr4:152643972 A/G cg22705602 chr4:152727874 NA 0.28 5.97 0.31 6.11e-9 Intelligence (multi-trait analysis); LUSC cis rs7617773 0.817 rs6801801 chr3:48326433 T/C cg20734569 chr3:48348370 SPINK8 -0.46 -8.09 -0.4 1.11e-14 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00320862 chr3:170588302 RPL22L1 -0.48 -5.95 -0.31 6.6e-9 Bipolar disorder and schizophrenia; LUSC cis rs4776059 0.959 rs12898644 chr15:52905233 A/G cg25063058 chr15:52860530 ARPP19 0.41 5.69 0.3 2.78e-8 Schizophrenia; LUSC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg07636037 chr3:49044803 WDR6 -0.44 -6.49 -0.33 3.15e-10 Resting heart rate; LUSC cis rs6545883 0.965 rs3771258 chr2:61764140 C/T cg15711740 chr2:61764176 XPO1 -0.5 -7.92 -0.4 3.58e-14 Tuberculosis; LUSC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11644478 chr21:40555479 PSMG1 0.95 18.51 0.71 3.91e-53 Cognitive function; LUSC trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg15934090 chr1:100435551 SLC35A3 0.48 8.32 0.41 2.2e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg03684893 chr10:554711 DIP2C -0.38 -7.08 -0.36 8.42e-12 Psychosis in Alzheimer's disease; LUSC cis rs1018836 0.564 rs7821994 chr8:91700916 C/T cg16814680 chr8:91681699 NA -1.09 -24.93 -0.81 3.14e-78 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg21132104 chr15:45694354 SPATA5L1 -0.56 -7.97 -0.4 2.6e-14 Homoarginine levels; LUSC trans rs853679 0.546 rs200949 chr6:27835435 A/G cg01620082 chr3:125678407 NA -0.62 -6.53 -0.34 2.45e-10 Depression; LUSC trans rs2727020 0.612 rs9787891 chr11:49413494 G/A cg15704280 chr7:45808275 SEPT13 -0.92 -14.23 -0.61 3.04e-36 Coronary artery disease; LUSC cis rs9814567 1.000 rs13059720 chr3:134242021 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 13.91 0.61 5.27e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs10411161 0.702 rs7250138 chr19:52385232 G/C cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg26727032 chr16:67993705 SLC12A4 -0.44 -5.86 -0.31 1.13e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg07701084 chr6:150067640 NUP43 0.5 7.48 0.38 6.61e-13 Lung cancer; LUSC cis rs7727544 0.582 rs3792894 chr5:131547271 C/T cg14196790 chr5:131705035 SLC22A5 0.4 6.85 0.35 3.54e-11 Blood metabolite levels; LUSC cis rs4595586 0.525 rs7968458 chr12:39377139 C/A cg26384229 chr12:38710491 ALG10B 0.49 7.02 0.36 1.28e-11 Morning vs. evening chronotype; LUSC cis rs62400317 0.826 rs10807321 chr6:45330974 T/C cg18551225 chr6:44695536 NA -0.44 -7.32 -0.37 1.92e-12 Total body bone mineral density; LUSC cis rs9311676 0.632 rs56033718 chr3:58446398 A/G cg26110898 chr3:58419937 PDHB 0.41 6.83 0.35 4.11e-11 Systemic lupus erythematosus; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22712797 chr1:65720580 NA 0.44 6.13 0.32 2.5e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg01528321 chr10:82214614 TSPAN14 0.63 9.13 0.45 6.88e-18 Post bronchodilator FEV1; LUSC cis rs2219968 0.701 rs1994035 chr8:79003651 C/T cg00738934 chr8:78996279 NA -0.4 -7.25 -0.37 2.84e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg04362960 chr10:104952993 NT5C2 -0.46 -5.92 -0.31 7.92e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.28 6.12 0.32 2.61e-9 Electroencephalogram traits; LUSC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg04414720 chr1:150670196 GOLPH3L 0.57 9.13 0.45 6.81e-18 Tonsillectomy; LUSC cis rs716595 1.000 rs12412423 chr10:112002170 C/G cg13996003 chr10:112034540 MXI1 -0.71 -5.8 -0.3 1.55e-8 Normalized brain volume; LUSC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg18252515 chr7:66147081 NA 1.2 13.62 0.6 6.4e-34 Diabetic kidney disease; LUSC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.18 0.41 6.01e-15 Parkinson's disease; LUSC cis rs7589342 0.899 rs879900 chr2:106494347 A/G cg14210321 chr2:106509881 NCK2 -0.57 -8.69 -0.43 1.66e-16 Addiction; LUSC cis rs2295359 1.000 rs9729046 chr1:67607082 C/G cg12940439 chr1:67600707 NA 0.39 6.42 0.33 4.68e-10 Psoriasis; LUSC cis rs9790314 0.967 rs9821201 chr3:160996155 G/C cg03342759 chr3:160939853 NMD3 -0.5 -8.44 -0.42 9.97e-16 Morning vs. evening chronotype; LUSC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.23 0.45 3.24e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg21782813 chr7:2030301 MAD1L1 0.36 5.97 0.31 5.91e-9 Bipolar disorder and schizophrenia; LUSC cis rs2882667 0.537 rs7704790 chr5:138410096 A/C cg04439458 chr5:138467593 SIL1 -0.33 -6.73 -0.35 7.56e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg05855489 chr10:104503620 C10orf26 -0.67 -9.93 -0.48 1.56e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9467773 0.620 rs2494716 chr6:26662736 T/C cg05738196 chr6:26577821 NA 0.79 14.93 0.63 5.72e-39 Intelligence (multi-trait analysis); LUSC cis rs652260 0.819 rs55656533 chr19:7902976 G/C cg26014689 chr19:7917955 EVI5L -0.49 -8.57 -0.42 3.87e-16 Menarche (age at onset); LUSC cis rs611744 0.647 rs12675265 chr8:109268805 C/T cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.17e-10 Dupuytren's disease; LUSC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg00745463 chr17:30367425 LRRC37B -0.81 -9.49 -0.46 4.37e-19 Hip circumference adjusted for BMI; LUSC cis rs1348850 0.598 rs1405717 chr2:178500101 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.15 0.32 2.18e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs12136530 0.774 rs12092284 chr1:19778323 C/T cg01832549 chr1:19774989 CAPZB -0.32 -5.72 -0.3 2.34e-8 Lead levels in blood; LUSC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg12463550 chr7:65579703 CRCP 0.41 5.93 0.31 7.77e-9 Aortic root size; LUSC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.84 -0.54 3.05e-27 Extrinsic epigenetic age acceleration; LUSC cis rs2797160 1.000 rs2747720 chr6:126009458 A/G cg05901451 chr6:126070800 HEY2 0.57 8.54 0.42 4.71e-16 Endometrial cancer; LUSC cis rs9300255 0.544 rs1790100 chr12:123656725 G/T cg05973401 chr12:123451056 ABCB9 0.53 6.52 0.34 2.64e-10 Neutrophil percentage of white cells; LUSC cis rs2455601 1.000 rs7104661 chr11:8902501 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.5 -7.66 -0.39 2e-13 Schizophrenia; LUSC cis rs9467773 1.000 rs1884946 chr6:26545308 C/G cg09904177 chr6:26538194 HMGN4 0.75 14.37 0.62 8.69e-37 Intelligence (multi-trait analysis); LUSC cis rs35491132 1 rs35491132 chr6:27527227 GT/G cg26958806 chr6:27640298 NA 0.77 6.55 0.34 2.23e-10 Urinary tract infection frequency; LUSC cis rs1670533 1.000 rs6839931 chr4:1053172 A/G cg27284194 chr4:1044797 NA 0.6 8.95 0.44 2.51e-17 Recombination rate (females); LUSC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg19052272 chr2:3704530 ALLC 0.47 8.34 0.42 2.01e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs12541635 1.000 rs11992752 chr8:107083122 G/A cg10147462 chr8:107024639 NA -0.47 -8.61 -0.43 2.85e-16 Age of smoking initiation; LUSC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg21724239 chr8:58056113 NA 0.56 6.9 0.35 2.7e-11 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg27535305 chr1:53392650 SCP2 -0.48 -9.58 -0.46 2.21e-19 Monocyte count; LUSC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.23 0.52 4.91e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs4729127 1.000 rs7799378 chr7:94007546 C/G cg08292968 chr12:111020671 PPTC7 -0.56 -5.98 -0.31 5.84e-9 Intelligence; LUSC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg03563238 chr19:33554763 RHPN2 -0.37 -6.23 -0.32 1.37e-9 Bone properties (heel); LUSC cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg19077165 chr18:44547161 KATNAL2 -0.43 -6.23 -0.32 1.43e-9 Personality dimensions; LUSC trans rs61931739 0.534 rs1852222 chr12:34008665 C/A cg13010199 chr12:38710504 ALG10B 0.52 7.88 0.4 4.63e-14 Morning vs. evening chronotype; LUSC cis rs3809566 0.963 rs12148057 chr15:63331509 A/T cg05507819 chr15:63340323 TPM1 0.64 8.98 0.44 1.95e-17 Platelet count; LUSC cis rs950776 0.518 rs8053 chr15:78841220 T/C cg22563815 chr15:78856949 CHRNA5 -0.26 -6.25 -0.32 1.22e-9 Sudden cardiac arrest; LUSC cis rs2806561 0.765 rs605367 chr1:23518524 T/C cg12483005 chr1:23474871 LUZP1 0.42 6.63 0.34 1.36e-10 Height; LUSC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7605827 0.930 rs11676730 chr2:15563573 C/T cg19274914 chr2:15703543 NA 0.46 8.62 0.43 2.76e-16 Educational attainment (years of education); LUSC trans rs12637928 0.580 rs55688192 chr3:110183424 A/T cg17371621 chr15:61264283 RORA 0.36 6.0 0.31 5.1e-9 Neuroticism; LUSC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg20476274 chr7:133979776 SLC35B4 0.87 16.68 0.67 7.3e-46 Mean platelet volume; LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.62 0.54 2e-26 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg25072359 chr17:41440525 NA 0.68 9.5 0.46 4.34e-19 Menopause (age at onset); LUSC cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg22782873 chr19:19639568 YJEFN3 -0.48 -5.79 -0.3 1.64e-8 Bipolar disorder; LUSC cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.16 -0.32 2.07e-9 Total body bone mineral density; LUSC cis rs11098499 0.863 rs9997631 chr4:120469995 C/G cg24375607 chr4:120327624 NA 0.74 11.15 0.52 9.57e-25 Corneal astigmatism; LUSC cis rs9325144 0.560 rs11183090 chr12:38662293 G/C cg13010199 chr12:38710504 ALG10B -0.53 -8.1 -0.41 1.03e-14 Morning vs. evening chronotype; LUSC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg07936489 chr17:37558343 FBXL20 -0.72 -9.75 -0.47 6.34e-20 Glomerular filtration rate (creatinine); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00714198 chr3:12705702 RAF1 -0.43 -6.18 -0.32 1.84e-9 Electrocardiographic conduction measures; LUSC cis rs56283067 0.847 rs12215181 chr6:44736076 C/T cg18551225 chr6:44695536 NA -0.49 -8.41 -0.42 1.17e-15 Total body bone mineral density; LUSC trans rs12614435 0.512 rs2472751 chr2:179539903 C/A cg14011486 chr1:26737247 LIN28 0.5 6.47 0.33 3.57e-10 Atrial fibrillation; LUSC cis rs8141797 0.710 rs9612563 chr22:24597540 A/C cg00411358 chr22:24577142 SUSD2 -0.6 -5.79 -0.3 1.65e-8 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs3806843 1.000 rs11167609 chr5:140200426 T/G cg19875535 chr5:140030758 IK 0.46 7.32 0.37 1.91e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg03709012 chr19:19516395 GATAD2A 0.83 14.07 0.61 1.24e-35 Tonsillectomy; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg27535305 chr1:53392650 SCP2 0.39 7.38 0.37 1.25e-12 Monocyte count; LUSC cis rs2797160 1.000 rs926853 chr6:126021435 A/T cg05901451 chr6:126070800 HEY2 0.58 8.86 0.44 4.86e-17 Endometrial cancer; LUSC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg12927641 chr6:109611667 NA -0.41 -7.07 -0.36 9.3e-12 Reticulocyte fraction of red cells; LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg03909863 chr11:638404 DRD4 -0.4 -5.91 -0.31 8.46e-9 Systemic lupus erythematosus; LUSC cis rs7712401 0.601 rs40818 chr5:122295073 T/C cg19077854 chr5:122220652 SNX24 0.43 9.81 0.47 3.89e-20 Mean platelet volume; LUSC cis rs1358748 0.522 rs4655516 chr1:67579882 A/C cg02640540 chr1:67518911 SLC35D1 0.63 6.1 0.32 2.9e-9 Tuberculosis; LUSC cis rs9902453 1.000 rs9896062 chr17:28357047 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.39 -0.42 1.35e-15 Coffee consumption (cups per day); LUSC cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg06064525 chr11:970664 AP2A2 -0.48 -10.56 -0.5 1.08e-22 Alzheimer's disease (late onset); LUSC cis rs7917772 0.582 rs10786683 chr10:104320476 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.97 0.51 3.99e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg22105103 chr4:187893119 NA -0.7 -12.77 -0.57 1.14e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg23711669 chr6:146136114 FBXO30 0.88 16.13 0.66 1.12e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs6488209 chr12:34319309 A/G cg26384229 chr12:38710491 ALG10B 0.65 10.52 0.5 1.55e-22 Morning vs. evening chronotype; LUSC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg26354017 chr1:205819088 PM20D1 0.53 8.6 0.43 3.06e-16 Menarche (age at onset); LUSC cis rs7000551 0.715 rs2461478 chr8:22378236 A/G cg12081754 chr8:22256438 SLC39A14 0.47 7.02 0.36 1.23e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7799006 0.929 rs6461233 chr7:2261468 G/A cg02951883 chr7:2050386 MAD1L1 -0.36 -6.03 -0.31 4.34e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9815354 1.000 rs9847975 chr3:41786904 A/G cg03022575 chr3:42003672 ULK4 0.65 6.92 0.35 2.3e-11 Pulse pressure;Diastolic blood pressure; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg13265914 chr8:21999630 REEP4 0.48 6.16 0.32 2.09e-9 Cognitive function;Information processing speed; LUSC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.21e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg27094323 chr7:1216898 NA -0.37 -6.53 -0.34 2.51e-10 Longevity;Endometriosis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21780294 chr1:43637871 EBNA1BP2;WDR65 -0.41 -6.07 -0.32 3.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg00431813 chr7:1051703 C7orf50 -0.43 -6.77 -0.35 5.84e-11 Longevity;Endometriosis; LUSC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg02896835 chr1:92012615 NA -0.65 -11.63 -0.54 1.79e-26 Breast cancer; LUSC cis rs6693567 0.545 rs11205375 chr1:150412474 C/T cg15654264 chr1:150340011 RPRD2 0.44 7.11 0.36 7.28e-12 Migraine; LUSC cis rs7937682 1.000 rs12363179 chr11:111568091 G/A cg09085632 chr11:111637200 PPP2R1B 1.08 15.88 0.66 1.05e-42 Primary sclerosing cholangitis; LUSC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg09455208 chr3:40491958 NA 0.51 9.26 0.45 2.49e-18 Renal cell carcinoma; LUSC trans rs9467711 0.790 rs66488313 chr6:26631568 G/T cg06606381 chr12:133084897 FBRSL1 -0.91 -7.77 -0.39 9.91e-14 Autism spectrum disorder or schizophrenia; LUSC cis rs17155006 0.746 rs419031 chr7:107750157 G/A cg05962710 chr7:107745446 LAMB4 -0.36 -6.36 -0.33 6.54e-10 Pneumococcal bacteremia; LUSC cis rs10992471 0.756 rs2761681 chr9:95186937 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.68 -0.3 3.01e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs40363 1.000 rs37768 chr16:3514777 T/C cg22508957 chr16:3507546 NAT15 0.86 10.92 0.51 5.95e-24 Tuberculosis; LUSC cis rs6500602 0.727 rs10451135 chr16:4580214 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 7.5 0.38 5.97e-13 Schizophrenia; LUSC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg08847533 chr14:75593920 NEK9 0.83 15.24 0.64 3.35e-40 Height; LUSC cis rs13418410 0.539 rs11677468 chr2:33839053 T/C cg04131969 chr2:33951647 MYADML -0.71 -10.5 -0.5 1.8e-22 Non-response to antidepressants and depression; LUSC cis rs727505 1.000 rs68091803 chr7:124526331 C/T cg23710748 chr7:124431027 NA -0.42 -7.42 -0.38 1e-12 Lewy body disease; LUSC cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg05283184 chr6:79620031 NA -0.57 -11.77 -0.54 5.39e-27 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg11344533 chr11:111475393 SIK2 -0.49 -6.89 -0.35 2.86e-11 Primary sclerosing cholangitis; LUSC cis rs1692580 0.870 rs263533 chr1:2163568 C/T cg24578937 chr1:2090814 PRKCZ 0.38 7.98 0.4 2.44e-14 Coronary artery disease; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07870486 chr7:56019566 MRPS17 -0.44 -6.43 -0.33 4.41e-10 Electrocardiographic conduction measures; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21194911 chr19:44716733 ZNF227 0.42 5.99 0.31 5.39e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg11301795 chr4:187892539 NA -0.81 -16.0 -0.66 3.69e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9921338 0.887 rs13330151 chr16:11402399 C/T cg00044050 chr16:11439710 C16orf75 -0.52 -6.72 -0.35 7.87e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg21138405 chr5:131827807 IRF1 -0.33 -5.79 -0.3 1.61e-8 Breast cancer;Mosquito bite size; LUSC trans rs7944735 0.567 rs7946766 chr11:48004369 C/T cg15704280 chr7:45808275 SEPT13 0.64 6.01 0.31 4.94e-9 Intraocular pressure; LUSC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.64 9.84 0.47 3.11e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504073 0.584 rs72641612 chr8:49947986 C/T cg00325661 chr8:49890786 NA 0.7 11.08 0.52 1.68e-24 Blood metabolite ratios; LUSC cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7923609 0.703 rs7100413 chr10:65330208 T/C cg01631684 chr10:65280961 REEP3 0.4 5.97 0.31 6.15e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs9951602 0.512 rs8098115 chr18:76653986 G/T cg02800362 chr5:177631904 HNRNPAB 0.88 13.12 0.58 5.45e-32 Obesity-related traits; LUSC cis rs12286929 0.610 rs11606838 chr11:115042859 C/A cg04055981 chr11:115044050 NA 0.41 7.46 0.38 7.46e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg24399712 chr22:39784796 NA -0.56 -8.96 -0.44 2.32e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs2854160 0.581 rs2727319 chr17:61960215 C/T cg11494091 chr17:61959527 GH2 0.39 6.67 0.34 1.07e-10 Height; LUSC cis rs7615952 0.866 rs13063119 chr3:125643847 G/A cg05084668 chr3:125655381 ALG1L -0.74 -11.37 -0.53 1.55e-25 Blood pressure (smoking interaction); LUSC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg12365402 chr11:9010492 NRIP3 -0.48 -8.9 -0.44 3.55e-17 Hemoglobin concentration; LUSC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg12963246 chr6:28129442 ZNF389 0.43 6.15 0.32 2.26e-9 Depression; LUSC cis rs4965006 1.000 rs4965006 chr12:132419533 A/G cg00588090 chr12:132412438 PUS1 -0.44 -7.61 -0.38 2.84e-13 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs34421088 0.506 rs2572428 chr8:11146672 T/A cg06636001 chr8:8085503 FLJ10661 0.49 7.41 0.38 1.07e-12 Neuroticism; LUSC cis rs977987 0.806 rs7202596 chr16:75491072 G/T cg04384234 chr16:75411784 CFDP1 -0.43 -6.99 -0.36 1.49e-11 Dupuytren's disease; LUSC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg08975724 chr8:8085496 FLJ10661 0.6 9.0 0.44 1.8e-17 Neuroticism; LUSC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg05717871 chr11:638507 DRD4 -0.37 -6.15 -0.32 2.18e-9 Systemic lupus erythematosus; LUSC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg11301795 chr4:187892539 NA 0.79 15.58 0.65 1.68e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg03146154 chr1:46216737 IPP 0.51 7.66 0.39 2.08e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg26384229 chr12:38710491 ALG10B 0.89 15.22 0.64 4.2e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs2439831 1.000 rs2467739 chr15:43740196 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.03 0.44 1.35e-17 Lung cancer in ever smokers; LUSC cis rs11098499 0.754 rs878372 chr4:120238780 A/C cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs354225 0.544 rs28581481 chr2:54812372 T/G cg26097391 chr2:54893211 SPTBN1 0.42 6.44 0.33 4.18e-10 Schizophrenia; LUSC cis rs9309473 0.950 rs10178678 chr2:73762236 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -6.51 -0.34 2.83e-10 Metabolite levels; LUSC cis rs7590368 0.683 rs72779459 chr2:10960650 T/C cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs2730245 0.959 rs2527201 chr7:158738611 G/T cg24397884 chr7:158709396 WDR60 -0.76 -12.13 -0.55 2.63e-28 Height; LUSC cis rs4969178 0.965 rs2292643 chr17:76395421 G/A cg20026190 chr17:76395443 PGS1 0.46 8.2 0.41 5.16e-15 HDL cholesterol levels; LUSC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg11871910 chr12:69753446 YEATS4 0.85 14.8 0.63 1.9e-38 Blood protein levels; LUSC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg06634786 chr22:41940651 POLR3H -0.6 -6.93 -0.35 2.13e-11 Vitiligo; LUSC cis rs1375194 0.582 rs13388224 chr2:33802902 T/C cg04131969 chr2:33951647 MYADML -0.64 -8.85 -0.44 5.04e-17 Response to antidepressants in depression; LUSC cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg06784218 chr1:46089804 CCDC17 0.56 11.62 0.54 1.92e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs926938 0.527 rs360666 chr1:115481290 C/T cg01522456 chr1:115632236 TSPAN2 -0.4 -6.33 -0.33 8.08e-10 Autism; LUSC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg25456477 chr12:86230367 RASSF9 -0.33 -5.72 -0.3 2.41e-8 Major depressive disorder; LUSC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg19680485 chr15:31195859 MTMR15 -0.46 -6.14 -0.32 2.37e-9 Huntington's disease progression; LUSC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg02951883 chr7:2050386 MAD1L1 -0.49 -8.72 -0.43 1.3e-16 Bipolar disorder and schizophrenia; LUSC cis rs11122272 0.766 rs2486732 chr1:231531476 A/C cg06096015 chr1:231504339 EGLN1 0.57 10.18 0.49 2.31e-21 Hemoglobin concentration; LUSC cis rs11229555 0.645 rs17474373 chr11:58191243 G/A cg15696309 chr11:58395628 NA -0.67 -8.13 -0.41 8.64e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs727505 1.000 rs727505 chr7:124462081 C/T cg23710748 chr7:124431027 NA -0.41 -7.52 -0.38 4.95e-13 Lewy body disease; LUSC trans rs12310956 0.510 rs4931743 chr12:33867588 T/C cg26384229 chr12:38710491 ALG10B 0.56 8.61 0.43 3.03e-16 Morning vs. evening chronotype; LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -8.93 -0.44 2.88e-17 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.05 -0.36 1.06e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg18681998 chr4:17616180 MED28 0.81 14.59 0.62 1.22e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg03929089 chr4:120376271 NA -1.04 -20.32 -0.74 2.46e-60 Height; LUSC trans rs62103177 1.000 rs62103177 chr18:77624479 G/A cg14227996 chr4:17616232 MED28 0.77 7.69 0.39 1.68e-13 Opioid sensitivity; LUSC cis rs6736093 0.966 rs34705448 chr2:112730089 C/T cg12686935 chr2:112915763 FBLN7 -0.37 -5.96 -0.31 6.32e-9 Coronary artery disease; LUSC cis rs290268 0.669 rs10448310 chr9:93556174 A/G cg02608019 chr9:93564028 SYK 0.5 8.01 0.4 1.93e-14 Platelet count; LUSC cis rs4285028 0.747 rs6791882 chr3:121373058 T/C cg11130432 chr3:121712080 ILDR1 -0.57 -8.17 -0.41 6.35e-15 Multiple sclerosis; LUSC trans rs9951602 0.651 rs2959408 chr18:76681702 T/C cg02800362 chr5:177631904 HNRNPAB -0.6 -6.87 -0.35 3.24e-11 Obesity-related traits; LUSC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg06850241 chr22:41845214 NA 0.3 5.75 0.3 2.05e-8 Vitiligo; LUSC cis rs950173 1.000 rs6716901 chr2:172673453 C/T cg13550731 chr2:172543902 DYNC1I2 -0.65 -6.5 -0.34 2.92e-10 Hippocampal volume; LUSC cis rs7560272 0.723 rs2421548 chr2:73641240 A/G cg20560298 chr2:73613845 ALMS1 0.46 7.19 0.37 4.3e-12 Schizophrenia; LUSC cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -10.49 -0.5 1.96e-22 Chronic sinus infection; LUSC cis rs854765 0.583 rs11078406 chr17:17840823 G/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.42 -0.42 1.09e-15 Total body bone mineral density; LUSC trans rs79976124 0.837 rs12201218 chr6:66653619 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.68 -8.56 -0.42 4.31e-16 Type 2 diabetes; LUSC cis rs12594515 0.904 rs8032875 chr15:45998010 A/C cg19682013 chr15:45996608 NA 0.39 5.84 0.3 1.24e-8 Waist circumference;Weight; LUSC cis rs4474465 0.679 rs10899537 chr11:78222424 C/G cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg18681998 chr4:17616180 MED28 0.8 13.75 0.6 2.1e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg14530993 chr4:882597 GAK 0.67 7.39 0.37 1.21e-12 Intelligence (multi-trait analysis); LUSC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg12386194 chr3:101231763 SENP7 0.52 7.12 0.36 6.48e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4343996 0.935 rs4722673 chr7:3357183 C/G cg21248987 chr7:3385318 SDK1 -0.36 -6.16 -0.32 2.04e-9 Motion sickness; LUSC cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg00944433 chr1:107599041 PRMT6 -0.33 -6.04 -0.31 4e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs2295359 1.000 rs9729046 chr1:67607082 C/G cg17031739 chr1:67600172 NA 0.39 5.99 0.31 5.48e-9 Psoriasis; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26734912 chr5:128430241 ISOC1 0.46 6.08 0.32 3.32e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg12311346 chr5:56204834 C5orf35 0.87 12.67 0.57 2.67e-30 Initial pursuit acceleration; LUSC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg04455712 chr21:45112962 RRP1B 0.45 8.48 0.42 7.21e-16 Mean corpuscular volume; LUSC cis rs7647973 0.626 rs4855849 chr3:49653378 A/G cg03060546 chr3:49711283 APEH 0.63 7.53 0.38 4.92e-13 Menarche (age at onset); LUSC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11890956 chr21:40555474 PSMG1 1.04 20.95 0.75 8.37e-63 Cognitive function; LUSC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.29e-12 Developmental language disorder (linguistic errors); LUSC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg07701084 chr6:150067640 NUP43 0.5 7.44 0.38 8.36e-13 Lung cancer; LUSC cis rs2324229 0.861 rs1180201 chr6:83957742 C/G cg08257003 chr6:84140564 ME1 -0.25 -5.98 -0.31 5.72e-9 Platelet-derived growth factor BB levels; LUSC cis rs9467160 0.651 rs9393558 chr6:24454196 G/T cg20631270 chr6:24437470 GPLD1 0.38 5.99 0.31 5.39e-9 Liver enzyme levels; LUSC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28655083 0.879 rs1502444 chr16:77059172 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.42 -6.41 -0.33 5.06e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg20203395 chr5:56204925 C5orf35 -0.46 -6.81 -0.35 4.53e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs7215564 0.908 rs34950888 chr17:78661779 T/G cg23238734 chr17:78661607 RPTOR 0.47 6.07 0.32 3.4e-9 Myopia (pathological); LUSC trans rs1941687 0.672 rs1026257 chr18:31418131 C/T cg27147174 chr7:100797783 AP1S1 0.45 6.81 0.35 4.53e-11 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs11997175 0.646 rs6984073 chr8:33700070 G/A ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.2e-10 Body mass index; LUSC cis rs11122272 0.766 rs2790871 chr1:231543555 G/C cg06096015 chr1:231504339 EGLN1 0.54 9.31 0.45 1.7e-18 Hemoglobin concentration; LUSC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg22903471 chr2:27725779 GCKR -0.39 -6.53 -0.34 2.46e-10 Total body bone mineral density; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg17541715 chr7:1216824 NA -0.38 -6.05 -0.31 3.97e-9 Longevity;Endometriosis; LUSC cis rs4664304 1.000 rs6735923 chr2:160769588 A/G cg03641300 chr2:160917029 PLA2R1 -0.39 -6.48 -0.33 3.21e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7953508 0.750 rs11107119 chr12:93983132 T/A cg18151635 chr12:93972918 NA -0.56 -7.81 -0.39 7.49e-14 Pubertal anthropometrics; LUSC cis rs116095464 0.558 rs62346506 chr5:201594 T/C cg22496380 chr5:211416 CCDC127 -0.87 -8.93 -0.44 2.83e-17 Breast cancer; LUSC cis rs9653442 0.545 rs11681227 chr2:100754997 A/G cg07810366 chr2:100720526 AFF3 -0.45 -7.65 -0.39 2.11e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.79 0.3 1.58e-8 Intelligence (multi-trait analysis); LUSC cis rs2286885 0.965 rs4837092 chr9:129250251 T/C cg15282417 chr9:129245246 FAM125B 0.38 6.3 0.33 9.57e-10 Intraocular pressure; LUSC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg05844789 chr1:228464394 OBSCN -0.3 -5.71 -0.3 2.54e-8 Diastolic blood pressure; LUSC trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg06636001 chr8:8085503 FLJ10661 0.58 9.04 0.44 1.25e-17 Neuroticism; LUSC cis rs11711311 0.869 rs1026364 chr3:113370010 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.37 0.33 6.32e-10 IgG glycosylation; LUSC cis rs2290159 0.800 rs59821954 chr3:12687613 T/C cg23032965 chr3:12705835 RAF1 0.73 9.09 0.45 8.9e-18 Cholesterol, total; LUSC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg03676636 chr4:99064102 C4orf37 0.36 8.1 0.41 1.07e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1983170 0.935 rs578155 chr1:91976541 G/A cg25838465 chr1:92012736 NA -0.45 -6.28 -0.33 1.04e-9 Eosinophil percentage of white cells; LUSC cis rs1949733 1.000 rs2688223 chr4:8471398 T/C cg13073564 chr4:8508604 NA -0.45 -8.29 -0.41 2.84e-15 Response to antineoplastic agents; LUSC cis rs1044826 0.957 rs9882014 chr3:139176535 C/T cg00490450 chr3:139108681 COPB2 0.5 6.61 0.34 1.5e-10 Obesity-related traits; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.54 -8.32 -0.41 2.27e-15 Lymphocyte counts; LUSC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg19046167 chr17:80928561 B3GNTL1 0.39 6.31 0.33 8.72e-10 Breast cancer; LUSC cis rs4665630 0.522 rs889866 chr2:23885168 A/G cg08063864 chr2:24346004 PFN4;LOC375190 -0.73 -6.7 -0.34 8.74e-11 Hypertension; LUSC cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC trans rs637571 0.584 rs594689 chr11:65635559 G/A cg17712092 chr4:129076599 LARP1B -0.83 -12.42 -0.56 2.28e-29 Eosinophil percentage of white cells; LUSC cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg23649088 chr2:200775458 C2orf69 0.49 6.71 0.34 8.6e-11 Schizophrenia; LUSC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg17143192 chr8:8559678 CLDN23 0.64 9.54 0.46 3.03e-19 Obesity-related traits; LUSC cis rs2730245 0.510 rs2788471 chr7:158649786 G/T cg14689365 chr7:158441557 NCAPG2 0.52 7.53 0.38 4.76e-13 Height; LUSC cis rs12594515 1.000 rs11855509 chr15:45995474 C/T cg01629716 chr15:45996671 NA 0.39 5.87 0.31 1.08e-8 Waist circumference;Weight; LUSC cis rs7760949 0.963 rs1571565 chr6:13907185 A/G cg27413430 chr6:13925136 RNF182 0.5 7.46 0.38 7.54e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg08270630 chr22:50330655 NA -0.42 -6.43 -0.33 4.43e-10 Schizophrenia; LUSC cis rs7809950 0.911 rs7778250 chr7:107224565 C/A cg23024343 chr7:107201750 COG5 0.58 8.98 0.44 2.01e-17 Coronary artery disease; LUSC cis rs4356932 1.000 rs9884374 chr4:76946718 A/T cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23797839 chr10:60094994 UBE2D1 0.39 6.66 0.34 1.13e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg14844989 chr11:31128820 NA -0.37 -5.83 -0.3 1.27e-8 Red blood cell count; LUSC cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg08213375 chr14:104286397 PPP1R13B 0.44 7.88 0.4 4.56e-14 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs12291225 0.637 rs8570 chr11:14300759 C/G cg19336497 chr11:14380999 RRAS2 -0.57 -11.77 -0.54 5.28e-27 Sense of smell; LUSC cis rs2839186 0.721 rs13051200 chr21:47701693 A/T cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.06e-9 Testicular germ cell tumor; LUSC cis rs4065321 0.522 rs34648856 chr17:38149411 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.69 12.27 0.56 8.27e-29 White blood cell count (basophil);White blood cell count; LUSC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg15468180 chr1:107600409 PRMT6 -0.38 -6.12 -0.32 2.64e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7937682 0.883 rs1612013 chr11:111456293 A/G cg11344533 chr11:111475393 SIK2 -0.46 -6.35 -0.33 6.87e-10 Primary sclerosing cholangitis; LUSC cis rs709400 0.663 rs62007719 chr14:103943130 G/T cg24130564 chr14:104152367 KLC1 -0.41 -5.91 -0.31 8.4e-9 Body mass index; LUSC cis rs2230307 0.572 rs11805428 chr1:100641716 T/C cg24955406 chr1:100503596 HIAT1 -0.56 -5.75 -0.3 2.03e-8 Carotid intima media thickness; LUSC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.41 6.27 0.32 1.09e-9 Platelet count; LUSC cis rs12753569 0.934 rs10430051 chr1:76491628 T/G cg00791851 chr1:76518896 NA -0.31 -5.9 -0.31 8.69e-9 Personality dimensions; LUSC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg02018176 chr4:1364513 KIAA1530 0.45 7.37 0.37 1.39e-12 Obesity-related traits; LUSC cis rs7584330 0.737 rs12469894 chr2:238365528 T/C cg14458575 chr2:238380390 NA 0.68 12.06 0.55 4.8e-28 Prostate cancer; LUSC cis rs939658 0.805 rs59104559 chr15:79438784 A/G cg17916960 chr15:79447300 NA -0.52 -10.38 -0.49 4.68e-22 Refractive error; LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg02423579 chr7:2872169 GNA12 -0.47 -6.69 -0.34 9.18e-11 Height; LUSC cis rs7584330 0.554 rs10208231 chr2:238433225 C/T cg16989719 chr2:238392110 NA -0.39 -5.69 -0.3 2.79e-8 Prostate cancer; LUSC cis rs4727027 0.870 rs1534196 chr7:148790591 G/A cg23158103 chr7:148848205 ZNF398 -0.47 -7.78 -0.39 9.38e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg16325326 chr1:53192061 ZYG11B -1.01 -20.61 -0.75 1.71e-61 Monocyte count; LUSC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg26850624 chr5:429559 AHRR -0.42 -7.91 -0.4 3.74e-14 Cystic fibrosis severity; LUSC cis rs7617773 0.817 rs4131362 chr3:48329036 A/C cg20734569 chr3:48348370 SPINK8 -0.47 -8.17 -0.41 6.44e-15 Coronary artery disease; LUSC cis rs4919694 0.572 rs72846714 chr10:104878454 G/A cg04362960 chr10:104952993 NT5C2 0.9 11.69 0.54 1.06e-26 Arsenic metabolism; LUSC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg18833306 chr6:118973337 C6orf204 -0.45 -5.79 -0.3 1.64e-8 Diastolic blood pressure; LUSC cis rs2067615 0.542 rs4964184 chr12:107070425 A/T cg15890332 chr12:107067104 RFX4 0.35 6.37 0.33 6.22e-10 Heart rate; LUSC cis rs1371867 0.846 rs1660348 chr8:101315248 A/G cg06002616 chr8:101225028 SPAG1 -0.41 -6.92 -0.35 2.34e-11 Atrioventricular conduction; LUSC cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 12.82 0.57 7.03e-31 Chronic sinus infection; LUSC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg22166914 chr1:53195759 ZYG11B -0.57 -9.24 -0.45 3.07e-18 Monocyte count; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.45 -7.62 -0.38 2.58e-13 Lymphocyte counts; LUSC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15320075 chr8:145703422 NA -0.43 -7.02 -0.36 1.25e-11 Age at first birth; LUSC cis rs4704187 0.687 rs6889429 chr5:74482183 C/T cg03227963 chr5:74354835 NA 0.3 6.54 0.34 2.32e-10 Response to amphetamines; LUSC cis rs751728 0.643 rs12173787 chr6:33735471 G/C cg25922239 chr6:33757077 LEMD2 0.41 5.94 0.31 7.23e-9 Crohn's disease; LUSC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs4423214 0.959 rs11606611 chr11:71164046 C/G cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.05 0.55 5.22e-28 Motion sickness; LUSC cis rs9420 0.528 rs11229077 chr11:57399072 A/G cg23127183 chr11:57508653 C11orf31 0.46 6.45 0.33 4e-10 Schizophrenia; LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg13126279 chr21:47581558 C21orf56 -0.43 -6.34 -0.33 7.6e-10 Testicular germ cell tumor; LUSC cis rs11245387 0.633 rs2086945 chr10:126543993 C/T cg08799069 chr10:126477246 METTL10 0.46 6.8 0.35 4.81e-11 Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1); LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg25767906 chr1:53392781 SCP2 0.52 9.44 0.46 6.73e-19 Monocyte count; LUSC cis rs7618501 1.000 rs9855505 chr3:49792158 T/G cg24110177 chr3:50126178 RBM5 0.42 6.7 0.34 8.64e-11 Intelligence (multi-trait analysis); LUSC cis rs11190604 1.000 rs2273695 chr10:102259568 A/G cg07080220 chr10:102295463 HIF1AN 0.62 8.53 0.42 5.22e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg02426739 chr12:132285352 NA 0.35 5.83 0.3 1.3e-8 Migraine; LUSC cis rs7833986 0.501 rs2953901 chr8:56981824 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.46 0.56 1.61e-29 Height; LUSC cis rs9916302 0.706 rs6503500 chr17:37485925 C/T cg07936489 chr17:37558343 FBXL20 -0.82 -10.26 -0.49 1.19e-21 Glomerular filtration rate (creatinine); LUSC cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg11645453 chr3:52864694 ITIH4 -0.33 -7.37 -0.37 1.32e-12 Body mass index; LUSC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Bladder cancer; LUSC cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg22349387 chr12:9600060 DDX12 -0.43 -6.99 -0.36 1.49e-11 Breast size; LUSC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.49 -8.2 -0.41 5.38e-15 Total body bone mineral density; LUSC cis rs4466137 1.000 rs4466137 chr5:82985739 A/C cg15083037 chr5:83017644 HAPLN1 -0.59 -7.74 -0.39 1.21e-13 Prostate cancer; LUSC cis rs7017697 0.507 rs3816246 chr8:19682545 A/G cg03894339 chr8:19674705 INTS10 -0.55 -7.24 -0.37 3.11e-12 Breast cancer; LUSC cis rs7583236 0.500 rs6728352 chr2:70343432 G/A cg19638749 chr2:70312615 NA 0.57 5.77 0.3 1.79e-8 Obesity-related traits; LUSC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg17264618 chr3:40429014 ENTPD3 0.34 7.24 0.37 3.19e-12 Renal cell carcinoma; LUSC cis rs56077333 1 rs56077333 chr15:78899003 C/A cg06917634 chr15:78832804 PSMA4 -0.44 -5.9 -0.31 8.72e-9 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs8027181 0.839 rs7167076 chr15:73028873 G/A cg25632853 chr15:73088954 NA -0.3 -6.03 -0.31 4.39e-9 Triglyceride levels; LUSC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg11366901 chr6:160182831 ACAT2 0.91 12.34 0.56 4.35e-29 Age-related macular degeneration (geographic atrophy); LUSC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg11764359 chr7:65958608 NA -0.7 -10.62 -0.5 7.05e-23 Aortic root size; LUSC cis rs7107174 1.000 rs2511155 chr11:77969223 G/A cg02023728 chr11:77925099 USP35 0.5 7.22 0.37 3.42e-12 Testicular germ cell tumor; LUSC cis rs13221852 0.722 rs2177167 chr7:3423727 G/A cg21248987 chr7:3385318 SDK1 0.37 6.3 0.33 9.65e-10 Acute graft versus host disease in bone marrow transplantation (donor effect); LUSC cis rs7246967 0.604 rs58653025 chr19:22941617 T/C cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs9399401 0.710 rs12190271 chr6:142681409 A/G cg03128060 chr6:142623767 GPR126 -0.57 -9.56 -0.46 2.75e-19 Chronic obstructive pulmonary disease; LUSC cis rs9905704 0.718 rs193391 chr17:56672944 T/C cg12560992 chr17:57184187 TRIM37 0.51 5.91 0.31 8.67e-9 Testicular germ cell tumor; LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg21724239 chr8:58056113 NA -0.79 -9.68 -0.47 1.09e-19 Developmental language disorder (linguistic errors); LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg08088566 chr11:430123 ANO9 0.67 7.4 0.38 1.08e-12 Body mass index; LUSC cis rs12540874 0.542 rs3807562 chr7:50566671 G/A cg18232548 chr7:50535776 DDC -0.59 -9.08 -0.45 9.41e-18 Systemic sclerosis; LUSC cis rs6754311 0.593 rs313523 chr2:136432103 G/A cg07169764 chr2:136633963 MCM6 0.55 7.29 0.37 2.32e-12 Mosquito bite size; LUSC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg16447950 chr5:562315 NA -0.57 -6.95 -0.36 1.97e-11 Lung disease severity in cystic fibrosis; LUSC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.78 13.14 0.58 4.65e-32 Total body bone mineral density; LUSC cis rs6028335 0.674 rs8120715 chr20:37598781 G/A cg27552599 chr20:37590471 DHX35 0.46 5.85 0.3 1.19e-8 Alcohol and nicotine co-dependence; LUSC cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.5 -0.33 2.99e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg03709012 chr19:19516395 GATAD2A 0.74 11.28 0.53 3.17e-25 Tonsillectomy; LUSC cis rs950169 0.922 rs11639244 chr15:84832650 G/A cg17173187 chr15:85201210 NMB 0.37 6.64 0.34 1.26e-10 Schizophrenia; LUSC cis rs611744 0.529 rs13282825 chr8:109263237 T/C cg18478394 chr8:109455254 TTC35 0.44 6.81 0.35 4.63e-11 Dupuytren's disease; LUSC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg00012203 chr2:219082015 ARPC2 -0.7 -11.59 -0.54 2.53e-26 Colorectal cancer; LUSC cis rs6741892 0.536 rs6761563 chr2:38891406 A/T cg08308459 chr2:38893161 GALM -0.58 -5.95 -0.31 6.84e-9 5-HTT brain serotonin transporter levels; LUSC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg14196790 chr5:131705035 SLC22A5 0.42 6.82 0.35 4.29e-11 Breast cancer;Mosquito bite size; LUSC cis rs11122272 0.735 rs2749699 chr1:231520279 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.41 0.38 1.06e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs1003719 0.715 rs9980353 chr21:38558812 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.36 -0.49 5.47e-22 Eye color traits; LUSC cis rs7180079 0.620 rs2046356 chr15:64706259 G/A cg08069370 chr15:64387884 SNX1 0.51 5.64 0.3 3.55e-8 Monocyte count; LUSC cis rs4555082 0.834 rs11622165 chr14:105759761 C/A cg10792982 chr14:105748885 BRF1 0.51 8.74 0.43 1.12e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg20503657 chr10:835505 NA 1.21 16.68 0.67 7.04e-46 Eosinophil percentage of granulocytes; LUSC cis rs6582630 0.638 rs12424222 chr12:38548273 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.43 -0.33 4.49e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs701145 0.556 rs355762 chr3:154012614 G/A cg17054900 chr3:154042577 DHX36 0.44 5.77 0.3 1.82e-8 Coronary artery disease; LUSC cis rs713477 0.524 rs2341538 chr14:55895174 C/G cg13175173 chr14:55914753 NA 0.31 5.94 0.31 7.35e-9 Pediatric bone mineral content (femoral neck); LUSC cis rs12543725 0.799 rs13252660 chr8:142239381 C/T cg23750338 chr8:142222470 SLC45A4 -0.42 -7.68 -0.39 1.78e-13 Birth weight; LUSC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.83 0.47 3.37e-20 Major depressive disorder; LUSC cis rs7103411 0.637 rs6416056 chr11:27646745 A/G cg18117895 chr11:27722066 BDNF 0.46 5.97 0.31 6.09e-9 Menarche (age at onset);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg06112835 chr11:68658793 MRPL21 0.52 8.0 0.4 2.08e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg11764359 chr7:65958608 NA -0.78 -12.75 -0.57 1.29e-30 Aortic root size; LUSC trans rs7824557 0.751 rs2099456 chr8:11127001 A/C cg06636001 chr8:8085503 FLJ10661 0.55 8.77 0.43 9.05e-17 Retinal vascular caliber; LUSC cis rs13064411 0.696 rs13066742 chr3:113208423 T/C cg18753928 chr3:113234510 CCDC52 -0.54 -8.23 -0.41 4.16e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg02470736 chr12:50505862 C12orf62 -0.41 -6.01 -0.31 4.86e-9 Electrocardiographic conduction measures; LUSC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg14558262 chr17:40713999 COASY 0.54 8.71 0.43 1.47e-16 Colorectal or endometrial cancer; LUSC cis rs701145 0.938 rs1086106 chr3:154084032 C/T cg17054900 chr3:154042577 DHX36 0.81 7.86 0.4 5.38e-14 Coronary artery disease; LUSC cis rs9322817 0.617 rs9404574 chr6:105162372 T/C cg02098413 chr6:105308735 HACE1 -0.27 -5.68 -0.3 2.97e-8 Thyroid stimulating hormone; LUSC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg10523679 chr1:76189770 ACADM 0.91 16.29 0.67 2.67e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg16339924 chr4:17578868 LAP3 0.55 8.61 0.43 3.02e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7605827 0.930 rs6749663 chr2:15529705 T/G cg19274914 chr2:15703543 NA 0.46 9.07 0.44 1.07e-17 Educational attainment (years of education); LUSC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg18230493 chr5:56204884 C5orf35 -0.58 -9.01 -0.44 1.6e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs1949733 0.877 rs940133 chr4:8473614 T/C cg13073564 chr4:8508604 NA -0.46 -8.6 -0.43 3.15e-16 Response to antineoplastic agents; LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.87 -0.58 4.6e-31 Platelet count; LUSC cis rs9303401 0.659 rs7210432 chr17:56668170 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.64 0.6 5.58e-34 Cognitive test performance; LUSC cis rs7523273 0.627 rs2724389 chr1:207933648 T/C cg22525895 chr1:207977042 MIR29B2 0.41 6.66 0.34 1.16e-10 Schizophrenia; LUSC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg23711669 chr6:146136114 FBXO30 -0.91 -17.36 -0.69 1.44e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs367615 0.552 rs2963025 chr5:108733256 A/C cg17395555 chr5:108820864 NA -0.46 -7.98 -0.4 2.41e-14 Colorectal cancer (SNP x SNP interaction); LUSC cis rs1865760 0.566 rs9467672 chr6:26083904 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.18 0.41 5.91e-15 Height; LUSC cis rs4478858 0.735 rs4949382 chr1:31776731 A/G cg00250761 chr1:31883323 NA -0.35 -8.55 -0.42 4.58e-16 Alcohol dependence; LUSC trans rs561341 1.000 rs530209 chr17:30315287 A/G cg20587970 chr11:113659929 NA -1.31 -18.22 -0.71 5.26e-52 Hip circumference adjusted for BMI; LUSC cis rs968451 0.865 rs5757609 chr22:39707845 G/C cg17798944 chr22:39715225 SNORD43;RPL3 0.68 9.04 0.44 1.28e-17 Primary biliary cholangitis; LUSC cis rs7843479 0.562 rs4872191 chr8:21824547 A/G cg17168535 chr8:21777572 XPO7 0.85 15.63 0.65 1.04e-41 Mean corpuscular volume; LUSC cis rs16867335 1.000 rs16867335 chr2:181458934 C/T cg23363182 chr2:181467187 NA -0.47 -5.94 -0.31 7.31e-9 Survival in rectal cancer; LUSC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg05552183 chr6:42928497 GNMT 0.51 8.3 0.41 2.61e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.16 0.32 2.04e-9 Menopause (age at onset); LUSC cis rs9650657 0.530 rs6982381 chr8:10952500 A/T cg21775007 chr8:11205619 TDH -0.46 -6.77 -0.35 5.79e-11 Neuroticism; LUSC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg17724175 chr1:150552817 MCL1 0.36 6.51 0.34 2.7e-10 Tonsillectomy; LUSC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.66 0.3 3.26e-8 Menopause (age at onset); LUSC cis rs2153535 1.000 rs11243251 chr6:8368207 G/A cg21535247 chr6:8435926 SLC35B3 -0.42 -6.11 -0.32 2.82e-9 Motion sickness; LUSC cis rs2762353 0.935 rs1165215 chr6:25798932 G/A cg03264133 chr6:25882463 NA -0.42 -7.25 -0.37 2.97e-12 Blood metabolite levels; LUSC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.26 0.45 2.57e-18 Prudent dietary pattern; LUSC cis rs7927592 0.830 rs10896339 chr11:68302846 G/C cg16797656 chr11:68205561 LRP5 0.35 5.9 0.31 9.14e-9 Total body bone mineral density; LUSC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg20744362 chr22:50050164 C22orf34 0.39 8.1 0.41 1.04e-14 Monocyte count;Monocyte percentage of white cells; LUSC trans rs1027479 0.842 rs1391197 chr8:109723927 C/T cg14904725 chr13:113777045 F10 -0.25 -6.16 -0.32 2.15e-9 Facial morphology (factor 6, height of vermillion lower lip); LUSC cis rs4285028 0.948 rs7651226 chr3:121670802 G/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.69 -0.47 9.86e-20 Multiple sclerosis; LUSC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 7.66 0.39 2.05e-13 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.45 0.67 6.11e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10779751 0.632 rs2748876 chr1:11134157 T/G cg08854313 chr1:11322531 MTOR 0.84 12.47 0.56 1.44e-29 Body mass index; LUSC cis rs7615316 0.872 rs9879995 chr3:142307799 A/C cg16271453 chr3:142027066 XRN1 -0.35 -5.91 -0.31 8.62e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs8081395 0.801 rs2777895 chr17:57879610 A/G cg18434674 chr17:58106139 NA -0.27 -5.92 -0.31 8.01e-9 White blood cell count; LUSC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg18512352 chr11:47633146 NA -0.46 -9.04 -0.44 1.35e-17 Subjective well-being; LUSC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg04352962 chr1:209979756 IRF6 0.58 6.27 0.32 1.14e-9 Cleft lip with or without cleft palate; LUSC cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg16414030 chr3:133502952 NA -0.52 -8.44 -0.42 9.8e-16 Iron status biomarkers; LUSC trans rs6011368 0.642 rs6062362 chr20:62911229 A/G cg13869341 chr1:15865 WASH5P 0.41 6.41 0.33 5e-10 Clozapine-induced cytotoxicity; LUSC cis rs13385 0.769 rs4913078 chr5:139626680 A/T cg26211634 chr5:139558579 C5orf32 0.46 6.95 0.36 1.88e-11 Atrial fibrillation; LUSC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.25 -0.52 4.05e-25 Mean corpuscular volume; LUSC cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg16339924 chr4:17578868 LAP3 0.52 7.58 0.38 3.34e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1577917 0.958 rs1591437 chr6:86525305 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.75 -0.35 6.41e-11 Response to antipsychotic treatment; LUSC cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.68 0.43 1.82e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs2742234 0.541 rs10899782 chr10:43736361 A/T cg02780029 chr10:43622663 RET 0.34 5.65 0.3 3.36e-8 Hirschsprung disease; LUSC trans rs6089829 0.926 rs1060491 chr20:61665817 C/A cg23505145 chr19:12996616 KLF1 -0.64 -10.59 -0.5 8.64e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg22535103 chr8:58192502 C8orf71 -0.79 -8.5 -0.42 6.35e-16 Developmental language disorder (linguistic errors); LUSC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18404041 chr3:52824283 ITIH1 -0.53 -10.2 -0.49 1.97e-21 Electroencephalogram traits; LUSC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg25036284 chr2:26402008 FAM59B -0.7 -9.85 -0.47 3.01e-20 Gut microbiome composition (summer); LUSC cis rs6747952 0.866 rs4663854 chr2:239083167 C/T cg17459225 chr2:239074497 NA -0.34 -5.88 -0.31 1.01e-8 Mean corpuscular hemoglobin concentration; LUSC cis rs1775715 0.707 rs2799024 chr10:32166922 A/G cg04359828 chr10:32216031 ARHGAP12 0.41 7.03 0.36 1.19e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7264396 0.623 rs6119609 chr20:34039394 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.83 -0.35 3.92e-11 Total cholesterol levels; LUSC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg02187348 chr16:89574699 SPG7 0.5 7.72 0.39 1.38e-13 Multiple myeloma (IgH translocation); LUSC cis rs11997175 0.766 rs6995220 chr8:33708919 C/A ch.8.33884649F chr8:33765107 NA 0.37 5.8 0.3 1.5e-8 Body mass index; LUSC cis rs782590 0.902 rs3762513 chr2:55762957 C/T cg03859395 chr2:55845619 SMEK2 0.87 16.25 0.66 3.53e-44 Metabolic syndrome; LUSC trans rs7726839 0.540 rs58599998 chr5:596087 A/G cg11887960 chr12:57824829 NA 0.54 6.8 0.35 4.89e-11 Obesity-related traits; LUSC cis rs7809950 1.000 rs28714607 chr7:107106253 T/C cg23024343 chr7:107201750 COG5 -0.55 -8.74 -0.43 1.16e-16 Coronary artery disease; LUSC cis rs372883 0.901 rs407463 chr21:30722440 G/A cg08807101 chr21:30365312 RNF160 -0.42 -6.13 -0.32 2.52e-9 Pancreatic cancer; LUSC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg14019146 chr3:50243930 SLC38A3 0.32 6.91 0.35 2.49e-11 Intelligence (multi-trait analysis); LUSC cis rs4930561 0.765 rs1894204 chr11:67929671 C/T cg16338278 chr11:67432957 ALDH3B2 0.36 5.93 0.31 7.59e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs9640161 0.617 rs56019796 chr7:150009226 T/C cg17279839 chr7:150038598 RARRES2 0.43 6.95 0.36 1.93e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg07806771 chr7:64541737 NA 0.42 6.03 0.31 4.3e-9 Calcium levels; LUSC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg15445000 chr17:37608096 MED1 0.41 6.82 0.35 4.34e-11 Glomerular filtration rate (creatinine); LUSC trans rs57221529 0.766 rs12522303 chr5:555564 A/C cg25482853 chr8:67687455 SGK3 1.19 19.12 0.72 1.43e-55 Lung disease severity in cystic fibrosis; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg11965514 chr8:124253535 C8orf76 0.66 6.01 0.31 4.74e-9 Cognitive performance; LUSC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.28 0.37 2.47e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs250677 1.000 rs36082 chr5:148428844 C/G cg05026186 chr5:148520876 ABLIM3 -0.39 -5.78 -0.3 1.69e-8 Breast cancer; LUSC cis rs10752881 1.000 rs10797810 chr1:182980950 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.52 0.5 1.56e-22 Colorectal cancer; LUSC cis rs12410462 0.681 rs114950580 chr1:227673334 G/C cg23173402 chr1:227635558 NA 0.76 7.59 0.38 3.12e-13 Major depressive disorder; LUSC cis rs12220238 0.908 rs4746179 chr10:75940169 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.3 0.37 2.06e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7215564 0.908 rs35884143 chr17:78656043 A/G cg23238734 chr17:78661607 RPTOR 0.48 6.13 0.32 2.5e-9 Myopia (pathological); LUSC cis rs6120849 0.754 rs6120790 chr20:33599090 A/T cg24642439 chr20:33292090 TP53INP2 0.62 6.82 0.35 4.29e-11 Protein C levels; LUSC cis rs4969178 0.930 rs11077363 chr17:76397309 C/T cg20026190 chr17:76395443 PGS1 0.46 8.06 0.4 1.37e-14 HDL cholesterol levels; LUSC cis rs4478858 0.746 rs7544003 chr1:31689088 C/T cg00250761 chr1:31883323 NA 0.36 9.36 0.46 1.19e-18 Alcohol dependence; LUSC cis rs11252926 0.831 rs816570 chr10:680475 C/T cg16346588 chr10:242978 ZMYND11 -0.45 -6.15 -0.32 2.15e-9 Psychosis in Alzheimer's disease; LUSC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg06634786 chr22:41940651 POLR3H 0.49 5.76 0.3 1.91e-8 Vitiligo; LUSC cis rs679087 0.606 rs302344 chr12:29940953 A/G cg14258853 chr12:29935411 TMTC1 0.69 8.61 0.43 2.86e-16 Schizophrenia; LUSC cis rs6665290 0.901 rs68087483 chr1:227202668 T/C cg10327440 chr1:227177885 CDC42BPA -1.2 -35.46 -0.89 2.9e-115 Myeloid white cell count; LUSC cis rs12681287 0.752 rs34279109 chr8:87247944 G/A cg27223183 chr8:87520930 FAM82B -0.46 -5.78 -0.3 1.69e-8 Caudate activity during reward; LUSC trans rs561341 0.739 rs4795663 chr17:30214542 T/C cg20587970 chr11:113659929 NA 0.64 8.83 0.44 6.1e-17 Hip circumference adjusted for BMI; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20947082 chr1:233749643 KCNK1 -0.43 -6.0 -0.31 5.06e-9 Bipolar disorder and schizophrenia; LUSC cis rs208520 0.526 rs9354366 chr6:66788559 C/T cg07460842 chr6:66804631 NA -1.26 -27.65 -0.83 2.31e-88 Exhaled nitric oxide output; LUSC trans rs17133449 0.718 rs7923564 chr10:4753292 G/A cg17844448 chr7:27782764 TAX1BP1 -0.38 -6.2 -0.32 1.68e-9 Major depressive disorder; LUSC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08704250 chr15:31115839 NA -0.48 -7.13 -0.36 6.35e-12 Huntington's disease progression; LUSC cis rs11190604 1.000 rs11190596 chr10:102293238 C/G cg16342193 chr10:102329863 NA -0.39 -6.88 -0.35 2.96e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg06627628 chr2:24431161 ITSN2 -0.6 -7.16 -0.36 5.19e-12 Lymphocyte counts; LUSC cis rs2404618 0.593 rs7829532 chr8:1485190 C/A cg13402656 chr8:1511478 DLGAP2 -0.62 -10.39 -0.49 4.12e-22 Lung cancer; LUSC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg06850241 chr22:41845214 NA 0.34 6.33 0.33 7.95e-10 Vitiligo; LUSC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg08888203 chr3:10149979 C3orf24 0.62 8.65 0.43 2.17e-16 Alzheimer's disease; LUSC cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg11266682 chr4:10021025 SLC2A9 -0.5 -9.21 -0.45 3.77e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg22676075 chr6:135203613 NA 0.55 8.72 0.43 1.37e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg07212818 chr11:638076 DRD4 -0.38 -6.49 -0.33 3.07e-10 Systemic lupus erythematosus; LUSC cis rs3540 0.597 rs4620932 chr15:91036569 G/A cg22089800 chr15:90895588 ZNF774 0.63 9.42 0.46 7.7e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg22467129 chr15:76604101 ETFA -0.45 -7.13 -0.36 6.3e-12 Blood metabolite levels; LUSC cis rs9399135 0.967 rs4896122 chr6:135295081 T/C cg24558204 chr6:135376177 HBS1L 0.58 9.0 0.44 1.69e-17 Red blood cell count; LUSC cis rs9463078 0.625 rs500773 chr6:44888464 C/T cg25276700 chr6:44698697 NA -0.28 -5.86 -0.31 1.09e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC trans rs12210905 1.000 rs72843644 chr6:27211601 A/C cg11837749 chr1:55047332 ACOT11 0.58 5.98 0.31 5.64e-9 Hip circumference adjusted for BMI; LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs11758351 1.000 rs76722536 chr6:26192946 C/G cg01420254 chr6:26195488 NA 0.71 7.47 0.38 7.03e-13 Gout;Renal underexcretion gout; LUSC cis rs2739330 0.892 rs4822455 chr22:24255296 C/T cg10819733 chr22:24237672 NA -0.41 -6.14 -0.32 2.33e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 0.953 rs6985942 chr8:58173412 T/C cg22535103 chr8:58192502 C8orf71 -0.75 -9.55 -0.46 2.95e-19 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.816 rs409853 chr20:25506067 T/C cg03522245 chr20:25566470 NINL 0.36 5.74 0.3 2.14e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg04727924 chr7:799746 HEATR2 -0.56 -6.78 -0.35 5.48e-11 Cerebrospinal P-tau181p levels; LUSC cis rs6840360 0.571 rs11099823 chr4:152510565 T/G cg22705602 chr4:152727874 NA -0.33 -6.7 -0.34 9.13e-11 Intelligence (multi-trait analysis); LUSC cis rs2398893 1.000 rs12004383 chr9:96826239 G/T cg14459158 chr9:96720562 NA 0.34 6.49 0.33 3.15e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4409675 0.549 rs72872888 chr1:28239809 G/A cg23691781 chr1:28212827 C1orf38 0.33 7.96 0.4 2.79e-14 Corneal astigmatism; LUSC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg12311346 chr5:56204834 C5orf35 -0.9 -13.98 -0.61 2.72e-35 Initial pursuit acceleration; LUSC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg24060327 chr5:131705240 SLC22A5 -0.34 -5.71 -0.3 2.52e-8 Blood metabolite levels; LUSC cis rs2742417 0.603 rs9826208 chr3:45773991 C/T cg10512202 chr3:45649293 LIMD1 0.36 5.94 0.31 7.3e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4237845 0.537 rs7969844 chr12:58278271 C/T cg02175503 chr12:58329896 NA 0.45 6.56 0.34 2.02e-10 Intelligence (multi-trait analysis); LUSC cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 10.66 0.5 4.87e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs17086172 0.841 rs76610733 chr18:70268315 C/G cg02919422 chr8:55370544 SOX17 -0.74 -6.62 -0.34 1.41e-10 Airflow obstruction; LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.6 -8.18 -0.41 5.97e-15 Systemic lupus erythematosus; LUSC cis rs908922 0.676 rs7532535 chr1:152517597 T/A cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26789489 chr1:16941426 NBPF1 0.43 6.45 0.33 3.94e-10 Bipolar disorder and schizophrenia; LUSC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg15335139 chr3:50242325 SLC38A3 0.26 5.77 0.3 1.83e-8 Body mass index; LUSC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.18 0.52 7.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9902453 0.874 rs11653805 chr17:28378276 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.53 -0.5 1.46e-22 Coffee consumption (cups per day); LUSC cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg20406979 chr6:167373233 NA 0.24 5.71 0.3 2.55e-8 Crohn's disease; LUSC cis rs4803468 1.000 rs1473248 chr19:41923314 C/T cg05360949 chr19:41903737 BCKDHA;EXOSC5 -0.43 -6.0 -0.31 5.27e-9 Height; LUSC cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.44 -8.17 -0.41 6.26e-15 Monocyte percentage of white cells; LUSC trans rs11696501 0.739 rs6104250 chr20:44251479 C/T cg03272292 chr12:48577362 C12orf68 0.49 5.99 0.31 5.29e-9 Brain structure; LUSC cis rs8014204 0.604 rs7156590 chr14:75388183 C/T cg08847533 chr14:75593920 NEK9 0.52 7.62 0.38 2.72e-13 Caffeine consumption; LUSC cis rs6964587 0.869 rs10250014 chr7:91490208 T/C cg17063962 chr7:91808500 NA -0.52 -7.99 -0.4 2.17e-14 Breast cancer; LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg24675658 chr1:53192096 ZYG11B 0.59 9.39 0.46 9.87e-19 Monocyte count; LUSC cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg13010199 chr12:38710504 ALG10B -0.65 -10.21 -0.49 1.77e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg18876405 chr7:65276391 NA -0.55 -8.59 -0.43 3.48e-16 Aortic root size; LUSC cis rs6762 0.550 rs8672 chr11:838634 C/G cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.29 -0.41 2.86e-15 Mean platelet volume; LUSC cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg21535247 chr6:8435926 SLC35B3 -0.59 -9.12 -0.45 7.09e-18 Motion sickness; LUSC cis rs568617 0.953 rs645900 chr11:65648135 G/A cg19792802 chr11:65647270 CTSW -0.41 -6.25 -0.32 1.25e-9 Crohn's disease; LUSC cis rs3772130 0.885 rs9816844 chr3:121496324 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.23 0.49 1.48e-21 Cognitive performance; LUSC cis rs11997175 0.713 rs6997661 chr8:33638554 A/G ch.8.33884649F chr8:33765107 NA -0.47 -7.62 -0.38 2.6e-13 Body mass index; LUSC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg15704280 chr7:45808275 SEPT13 -1.02 -19.18 -0.72 8.14e-56 Height; LUSC cis rs10911251 0.528 rs10911265 chr1:183115071 C/T ch.1.3577855R chr1:183094577 LAMC1 0.69 10.51 0.5 1.67e-22 Colorectal cancer; LUSC cis rs9815354 0.597 rs73075211 chr3:42033424 G/T cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs6906287 0.647 rs12192682 chr6:118863594 A/G cg21191810 chr6:118973309 C6orf204 0.33 5.95 0.31 6.92e-9 Electrocardiographic conduction measures; LUSC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs68170813 0.559 rs6947675 chr7:106817184 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.68 -0.47 1.04e-19 Coronary artery disease; LUSC trans rs61931739 0.534 rs1490109 chr12:34064077 T/C cg26384229 chr12:38710491 ALG10B 0.71 11.0 0.52 3.26e-24 Morning vs. evening chronotype; LUSC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.62 -8.05 -0.4 1.49e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.43 0.53 8.95e-26 Prudent dietary pattern; LUSC trans rs9393777 0.777 rs56114371 chr6:27274834 C/T cg01620082 chr3:125678407 NA -0.74 -6.46 -0.33 3.63e-10 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg00684032 chr4:1343700 KIAA1530 0.37 6.48 0.33 3.36e-10 Obesity-related traits; LUSC cis rs2273669 0.667 rs28504359 chr6:109330417 C/T cg05315195 chr6:109294784 ARMC2 -0.53 -5.89 -0.31 9.28e-9 Prostate cancer; LUSC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg26335602 chr6:28129616 ZNF389 0.45 6.01 0.31 4.83e-9 Depression; LUSC cis rs9747201 0.962 rs34016823 chr17:80095428 G/T cg17462356 chr17:80056334 FASN 0.46 6.16 0.32 2.11e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10848704 0.956 rs10848703 chr12:2882250 C/T cg19995117 chr12:2880862 NA 0.55 10.58 0.5 9.53e-23 Quantitative traits; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg16393715 chr7:1948819 MAD1L1 0.36 6.2 0.32 1.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.581 rs8056141 chr16:75497162 A/T cg04384234 chr16:75411784 CFDP1 -0.49 -7.93 -0.4 3.27e-14 Dupuytren's disease; LUSC cis rs5758659 0.652 rs133323 chr22:42405922 T/C cg04733989 chr22:42467013 NAGA 0.39 6.55 0.34 2.22e-10 Cognitive function; LUSC cis rs9393777 0.623 rs9358946 chr6:26478927 G/A cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC cis rs9309473 0.500 rs4286298 chr2:73882108 T/A cg20560298 chr2:73613845 ALMS1 0.47 7.18 0.37 4.5e-12 Metabolite levels; LUSC cis rs2797160 1.000 rs1739347 chr6:126014157 C/T cg05901451 chr6:126070800 HEY2 0.56 8.52 0.42 5.63e-16 Endometrial cancer; LUSC cis rs2760061 0.819 rs3094914 chr1:228206934 C/T cg02753203 chr1:228287806 NA 0.72 12.56 0.57 6.61e-30 Diastolic blood pressure; LUSC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg15468180 chr1:107600409 PRMT6 0.38 6.02 0.31 4.53e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -12.87 -0.58 4.6e-31 Platelet count; LUSC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg13390004 chr1:15929781 NA 0.41 6.76 0.35 6.35e-11 Systolic blood pressure; LUSC cis rs9393777 0.588 rs6456728 chr6:26477779 G/A cg12826209 chr6:26865740 GUSBL1 0.64 7.35 0.37 1.55e-12 Intelligence (multi-trait analysis); LUSC cis rs10761482 0.531 rs10740029 chr10:62238902 G/A cg18175470 chr10:62150864 ANK3 -0.46 -6.38 -0.33 5.9e-10 Schizophrenia; LUSC cis rs3849570 1.000 rs78242412 chr3:81747219 A/G cg07356753 chr3:81810745 GBE1 -0.69 -10.93 -0.51 5.51e-24 Waist circumference;Body mass index; LUSC cis rs1448094 0.967 rs7974794 chr12:86323280 A/G cg00310523 chr12:86230176 RASSF9 0.39 6.98 0.36 1.58e-11 Major depressive disorder; LUSC cis rs2652834 1.000 rs8032104 chr15:63400584 A/G cg05507819 chr15:63340323 TPM1 0.67 8.15 0.41 7.6e-15 HDL cholesterol; LUSC cis rs7089973 0.872 rs17092542 chr10:116630289 G/A cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 5.96e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs8014204 0.816 rs28426374 chr14:75346740 C/T cg06637938 chr14:75390232 RPS6KL1 -0.55 -8.79 -0.43 8.26e-17 Caffeine consumption; LUSC cis rs56283067 0.847 rs60328783 chr6:44693099 C/G cg18551225 chr6:44695536 NA -0.49 -8.27 -0.41 3.22e-15 Total body bone mineral density; LUSC trans rs877282 0.945 rs17293517 chr10:778770 C/T cg22713356 chr15:30763199 NA 1.09 15.4 0.64 8.48e-41 Uric acid levels; LUSC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg21770322 chr7:97807741 LMTK2 -0.46 -8.12 -0.41 8.94e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg24503407 chr1:205819492 PM20D1 0.9 16.85 0.68 1.6e-46 Menarche (age at onset); LUSC cis rs2798269 0.966 rs1200039 chr13:22110476 A/C cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.07 -0.32 3.52e-9 PR segment; LUSC cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg18252515 chr7:66147081 NA -1.23 -13.78 -0.6 1.62e-34 Diabetic kidney disease; LUSC cis rs10782582 0.593 rs12131344 chr1:76136437 C/T cg03433033 chr1:76189801 ACADM -0.46 -6.45 -0.33 3.86e-10 Daytime sleep phenotypes; LUSC cis rs17155006 0.655 rs448742 chr7:107733993 C/T cg05962710 chr7:107745446 LAMB4 0.32 5.73 0.3 2.27e-8 Pneumococcal bacteremia; LUSC cis rs11785400 1.000 rs3824208 chr8:143743653 C/G cg24634471 chr8:143751801 JRK 0.59 9.01 0.44 1.66e-17 Schizophrenia; LUSC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg13647721 chr17:30228624 UTP6 0.57 5.65 0.3 3.43e-8 Hip circumference adjusted for BMI; LUSC cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg12011299 chr4:100065546 ADH4 0.73 12.13 0.55 2.69e-28 Alcohol dependence; LUSC cis rs1005224 0.853 rs9323616 chr14:76151697 T/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.68 -9.2 -0.45 4.01e-18 Large artery stroke; LUSC cis rs10876993 0.928 rs1678530 chr12:58054076 A/C cg15848620 chr12:58087721 OS9 -0.53 -7.63 -0.39 2.45e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs9479482 0.967 rs13209192 chr6:150350099 A/G cg07578070 chr6:150326732 RAET1K 0.36 5.67 0.3 3.1e-8 Alopecia areata; LUSC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11890956 chr21:40555474 PSMG1 -0.73 -11.42 -0.53 9.81e-26 Menarche (age at onset); LUSC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg07701084 chr6:150067640 NUP43 0.53 7.8 0.39 7.88e-14 Lung cancer; LUSC cis rs2731664 0.792 rs385981 chr5:176886539 C/T cg23176889 chr5:176863531 GRK6 -0.68 -13.95 -0.61 3.62e-35 Intelligence (multi-trait analysis); LUSC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg11344533 chr11:111475393 SIK2 0.45 6.09 0.32 3.14e-9 Primary sclerosing cholangitis; LUSC cis rs12291225 0.679 rs11023170 chr11:14294909 A/G cg05501817 chr11:14380813 RRAS2 -0.57 -8.9 -0.44 3.72e-17 Sense of smell; LUSC cis rs6738485 0.531 rs72819612 chr2:106846316 T/C cg15412446 chr2:106886593 NA -0.56 -6.33 -0.33 7.68e-10 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg00814883 chr7:100076585 TSC22D4 -0.67 -8.07 -0.4 1.26e-14 Platelet count; LUSC cis rs2073300 1.000 rs6132622 chr20:23442240 A/T cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg12751644 chr20:60527061 NA -0.33 -5.9 -0.31 8.75e-9 Body mass index; LUSC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.61e-8 Life satisfaction; LUSC cis rs713477 1.000 rs7149622 chr14:55909402 T/C cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs2230307 0.536 rs473759 chr1:100557282 C/G cg24955406 chr1:100503596 HIAT1 0.59 6.41 0.33 4.9e-10 Carotid intima media thickness; LUSC cis rs1044826 0.956 rs2233811 chr3:139195860 C/G cg00490450 chr3:139108681 COPB2 0.52 6.76 0.35 6.18e-11 Obesity-related traits; LUSC cis rs2219968 0.961 rs1121551 chr8:78958512 A/G cg00738934 chr8:78996279 NA 0.34 6.11 0.32 2.76e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg13047869 chr3:10149882 C3orf24 0.63 8.73 0.43 1.21e-16 Alzheimer's disease; LUSC cis rs9287719 0.967 rs4613248 chr2:10744051 C/T cg00105475 chr2:10696890 NA 0.38 6.28 0.32 1.06e-9 Prostate cancer; LUSC cis rs477692 1.000 rs530466 chr10:131427717 A/G cg26102564 chr10:131424627 MGMT 0.43 6.78 0.35 5.54e-11 Response to temozolomide; LUSC cis rs983392 0.679 rs764859 chr11:59978255 C/G cg20284999 chr11:59952153 MS4A6A -0.36 -6.02 -0.31 4.68e-9 Alzheimer's disease (late onset); LUSC cis rs9341808 0.538 rs688867 chr6:80939228 A/G cg08355045 chr6:80787529 NA 0.4 6.89 0.35 2.82e-11 Sitting height ratio; LUSC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg11764359 chr7:65958608 NA -0.55 -7.3 -0.37 2.13e-12 Aortic root size; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.63 0.39 2.44e-13 Prudent dietary pattern; LUSC cis rs7598759 0.675 rs6727530 chr2:232332058 T/C cg19187155 chr2:232395269 NMUR1 0.49 7.2 0.37 3.96e-12 Noise-induced hearing loss; LUSC cis rs854572 0.600 rs854570 chr7:94952692 C/A cg01874867 chr7:94954059 PON1 0.41 7.89 0.4 4.49e-14 Paraoxonase activity; LUSC cis rs2742417 1.000 rs2742423 chr3:45733430 A/G cg09608765 chr3:45636137 LIMD1 -0.34 -6.84 -0.35 3.8e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs8014204 0.816 rs10083386 chr14:75347585 C/A cg08847533 chr14:75593920 NEK9 -0.41 -6.04 -0.31 4.04e-9 Caffeine consumption; LUSC cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg23029597 chr12:123009494 RSRC2 -0.71 -9.23 -0.45 3.14e-18 Body mass index; LUSC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg11663144 chr21:46675770 NA -0.43 -7.39 -0.37 1.22e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8077889 0.703 rs72836567 chr17:41945776 G/A cg26893861 chr17:41843967 DUSP3 0.9 11.24 0.52 4.53e-25 Triglycerides; LUSC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg00908189 chr16:619842 PIGQ 0.67 10.32 0.49 7.66e-22 Height; LUSC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg10792982 chr14:105748885 BRF1 0.48 8.35 0.42 1.83e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7937682 0.924 rs499750 chr11:111513645 T/G cg19812747 chr11:111475976 SIK2 -0.51 -7.21 -0.37 3.81e-12 Primary sclerosing cholangitis; LUSC trans rs12188164 1.000 rs55842567 chr5:437586 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 6.04 0.31 4.19e-9 Cystic fibrosis severity; LUSC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg19592336 chr6:28129416 ZNF389 0.46 5.93 0.31 7.48e-9 Depression; LUSC trans rs10990032 1.000 rs1364820 chr9:105143745 A/G cg09125300 chr8:22447068 PDLIM2 0.65 5.96 0.31 6.48e-9 Response to fenofibrate (triglyceride levels); LUSC cis rs12493885 0.818 rs61791541 chr3:153758155 G/T cg17054900 chr3:154042577 DHX36 -0.61 -6.46 -0.33 3.78e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg12463550 chr7:65579703 CRCP -0.41 -5.91 -0.31 8.35e-9 Aortic root size; LUSC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg22029157 chr1:209979665 IRF6 0.74 10.99 0.52 3.49e-24 Cleft lip with or without cleft palate; LUSC cis rs7804356 0.953 rs73067476 chr7:26857240 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.14 -0.32 2.4e-9 Type 1 diabetes; LUSC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23248424 chr5:179741104 GFPT2 -0.46 -7.33 -0.37 1.71e-12 Height; LUSC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs7123876 0.587 rs11604034 chr11:72364147 G/C cg04827223 chr11:72435913 ARAP1 -0.63 -7.38 -0.37 1.25e-12 Body mass index; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg12564285 chr5:131593104 PDLIM4 0.46 8.86 0.44 4.87e-17 Blood metabolite levels; LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg10729496 chr3:10149963 C3orf24 0.59 7.89 0.4 4.31e-14 Alzheimer's disease; LUSC cis rs12681287 0.547 rs66808088 chr8:87521212 C/T cg00550725 chr8:87521180 FAM82B 0.44 5.77 0.3 1.83e-8 Caudate activity during reward; LUSC cis rs11785400 0.793 rs2976399 chr8:143746050 C/T cg24634471 chr8:143751801 JRK 0.52 7.27 0.37 2.62e-12 Schizophrenia; LUSC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg04414720 chr1:150670196 GOLPH3L 0.54 8.53 0.42 5.19e-16 Melanoma; LUSC cis rs1881396 0.947 rs4666010 chr2:27878686 T/C cg27432699 chr2:27873401 GPN1 0.64 8.61 0.43 3.03e-16 Nonalcoholic fatty liver disease; LUSC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg19318889 chr4:1322082 MAEA 0.48 7.83 0.39 6.69e-14 Obesity-related traits; LUSC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg20243544 chr17:37824526 PNMT 0.39 5.96 0.31 6.59e-9 Self-reported allergy; LUSC cis rs8040855 0.690 rs8041189 chr15:85686327 A/G cg04831495 chr15:85060580 GOLGA6L5 0.38 5.65 0.3 3.5e-8 Bulimia nervosa; LUSC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg15145296 chr3:125709740 NA -0.56 -6.29 -0.33 9.71e-10 Blood pressure (smoking interaction); LUSC trans rs514406 0.929 rs2607095 chr1:53325639 T/C cg24643429 chr1:3562429 WDR8 0.33 6.04 0.31 4.2e-9 Monocyte count; LUSC cis rs5769765 0.954 rs6009900 chr22:50236610 T/C cg02269571 chr22:50332266 NA -0.56 -8.29 -0.41 2.72e-15 Schizophrenia; LUSC cis rs4268898 0.552 rs35331966 chr2:24367828 C/T cg06627628 chr2:24431161 ITSN2 0.52 7.36 0.37 1.47e-12 Asthma; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg20295408 chr7:1910781 MAD1L1 -0.41 -5.78 -0.3 1.71e-8 Bipolar disorder and schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg05900430 chr19:48825159 NA -0.4 -5.95 -0.31 6.62e-9 Electrocardiographic conduction measures; LUSC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.63 -9.88 -0.48 2.23e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6121246 0.567 rs6058197 chr20:30194899 A/G cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg12310025 chr6:25882481 NA -0.74 -12.03 -0.55 6.04e-28 Intelligence (multi-trait analysis); LUSC trans rs3942852 0.568 rs2904315 chr11:48109948 C/T cg03929089 chr4:120376271 NA 0.6 7.84 0.39 6.26e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs738322 0.967 rs4383 chr22:38570927 C/G cg17652424 chr22:38574118 PLA2G6 -0.29 -6.41 -0.33 5e-10 Cutaneous nevi; LUSC cis rs11785400 0.753 rs9694286 chr8:143737157 G/T cg10596483 chr8:143751796 JRK 0.52 7.52 0.38 5.15e-13 Schizophrenia; LUSC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg11871910 chr12:69753446 YEATS4 0.91 16.98 0.68 4.65e-47 Cerebrospinal fluid biomarker levels; LUSC cis rs9309473 0.660 rs56131703 chr2:73847260 C/T cg20560298 chr2:73613845 ALMS1 -0.53 -6.19 -0.32 1.72e-9 Metabolite levels; LUSC cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg00484396 chr16:3507460 NAT15 -0.43 -7.03 -0.36 1.18e-11 Body mass index (adult); LUSC cis rs1371867 0.846 rs1660312 chr8:101330634 C/G cg06636551 chr8:101224915 SPAG1 -0.45 -8.11 -0.41 9.95e-15 Atrioventricular conduction; LUSC cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg18132916 chr6:79620363 NA -0.39 -6.02 -0.31 4.64e-9 Intelligence (multi-trait analysis); LUSC cis rs10779751 1.000 rs12730522 chr1:11284091 G/A cg08854313 chr1:11322531 MTOR 0.93 15.93 0.66 6.78e-43 Body mass index; LUSC cis rs2762353 0.935 rs1185567 chr6:25818588 A/G cg03264133 chr6:25882463 NA -0.44 -7.74 -0.39 1.16e-13 Blood metabolite levels; LUSC cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg06028605 chr16:24865363 SLC5A11 0.49 8.49 0.42 6.67e-16 Intelligence (multi-trait analysis); LUSC cis rs2976388 1.000 rs2920298 chr8:143763043 A/G cg17252645 chr8:143867129 LY6D -0.36 -6.31 -0.33 9.04e-10 Urinary tract infection frequency; LUSC cis rs9325144 0.647 rs12231313 chr12:39101929 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.7 -0.47 9.52e-20 Morning vs. evening chronotype; LUSC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg18876405 chr7:65276391 NA 0.59 9.72 0.47 8.16e-20 Aortic root size; LUSC cis rs6681460 0.966 rs7524851 chr1:67093018 T/C cg02459107 chr1:67143332 SGIP1 0.46 8.54 0.42 4.73e-16 Presence of antiphospholipid antibodies; LUSC trans rs9393777 0.720 rs57713596 chr6:27004098 C/T cg06606381 chr12:133084897 FBRSL1 -0.62 -6.53 -0.34 2.38e-10 Intelligence (multi-trait analysis); LUSC cis rs7560272 0.538 rs4852972 chr2:73916672 C/T cg20560298 chr2:73613845 ALMS1 0.38 5.81 0.3 1.5e-8 Schizophrenia; LUSC trans rs60843830 0.964 rs7584915 chr2:264227 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 10.36 0.49 5.43e-22 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg23625390 chr15:77176239 SCAPER 0.52 7.99 0.4 2.17e-14 Blood metabolite levels; LUSC cis rs68170813 0.559 rs3815148 chr7:106938420 G/T cg02696742 chr7:106810147 HBP1 0.61 9.64 0.47 1.45e-19 Coronary artery disease; LUSC cis rs11640436 0.565 rs12926676 chr16:77309505 G/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.37 5.76 0.3 1.94e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7805747 1.000 rs10480299 chr7:151405818 A/G cg17611936 chr7:151411526 PRKAG2 0.46 6.29 0.33 9.69e-10 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); LUSC cis rs11098499 0.754 rs9991959 chr4:120253773 C/T cg09307838 chr4:120376055 NA -0.68 -10.84 -0.51 1.14e-23 Corneal astigmatism; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -9.54 -0.46 3.1400000000000002e-19 Bipolar disorder and schizophrenia; LUSC cis rs13401104 0.796 rs1466207 chr2:237121350 C/T cg19324714 chr2:237145437 ASB18 0.44 5.66 0.3 3.34e-8 Educational attainment; LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg24060327 chr5:131705240 SLC22A5 0.66 11.0 0.52 3.24e-24 Breast cancer; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg07157834 chr1:205819609 PM20D1 0.85 15.26 0.64 2.83e-40 Menarche (age at onset); LUSC cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg00484396 chr16:3507460 NAT15 -0.46 -6.75 -0.35 6.7e-11 Body mass index (adult); LUSC cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg00631329 chr6:26305371 NA -0.46 -9.18 -0.45 4.58e-18 Educational attainment; LUSC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg22868518 chr11:507468 RNH1 -0.63 -5.87 -0.31 1.08e-8 Body mass index; LUSC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg19318889 chr4:1322082 MAEA 0.75 12.92 0.58 2.98e-31 Longevity; LUSC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg26677194 chr12:130822605 PIWIL1 0.59 8.51 0.42 6.12e-16 Menopause (age at onset); LUSC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg13395646 chr4:1353034 KIAA1530 -0.6 -9.34 -0.46 1.39e-18 Longevity; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg12143784 chr7:64541923 NA 0.36 5.65 0.3 3.5e-8 Calcium levels; LUSC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg00255919 chr5:131827918 IRF1 0.43 8.25 0.41 3.62e-15 Asthma (sex interaction); LUSC trans rs12682352 0.602 rs1473029 chr8:8668917 A/C cg27411982 chr8:10470053 RP1L1 0.4 6.13 0.32 2.49e-9 Neuroticism; LUSC cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.62 0.34 1.48e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 6.16 0.32 2.14e-9 Tonsillectomy; LUSC cis rs17345786 0.906 rs58835747 chr3:101243634 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.75 0.39 1.14e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs8114671 0.836 rs6058154 chr20:33585834 C/T cg07148914 chr20:33460835 GGT7 -0.49 -7.27 -0.37 2.57e-12 Height; LUSC cis rs2742234 0.541 rs11238483 chr10:43728780 A/G cg02780029 chr10:43622663 RET 0.34 5.7 0.3 2.58e-8 Hirschsprung disease; LUSC cis rs11676348 0.846 rs4674257 chr2:218988774 A/G cg06547715 chr2:218990976 CXCR2 0.33 6.47 0.33 3.57e-10 Ulcerative colitis; LUSC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg06027949 chr8:82754900 SNX16 -0.43 -5.81 -0.3 1.48e-8 Diastolic blood pressure; LUSC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg00701064 chr4:6280414 WFS1 0.59 14.24 0.61 2.82e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs9486719 1.000 rs67996804 chr6:96884387 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs7267979 1.000 rs2500404 chr20:25359758 A/C cg03522245 chr20:25566470 NINL -0.35 -5.78 -0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg08847533 chr14:75593920 NEK9 0.86 16.21 0.66 5.13e-44 Height; LUSC cis rs7582180 0.625 rs11892034 chr2:100938952 T/C cg12002119 chr2:101014098 CHST10 0.35 5.81 0.3 1.5e-8 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg21573476 chr21:45109991 RRP1B 0.37 5.89 0.31 9.5e-9 Mean corpuscular volume; LUSC cis rs4666002 0.750 rs13021208 chr2:27901728 C/T cg27432699 chr2:27873401 GPN1 0.54 7.12 0.36 6.59e-12 Phospholipid levels (plasma); LUSC cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg23711669 chr6:146136114 FBXO30 -0.82 -14.68 -0.63 5.24e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg02269571 chr22:50332266 NA -0.6 -8.97 -0.44 2.2e-17 Schizophrenia; LUSC cis rs6500395 1.000 rs9924078 chr16:48557918 A/C cg04672837 chr16:48644449 N4BP1 -0.43 -6.24 -0.32 1.29e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg08873628 chr1:175162347 KIAA0040 0.39 5.67 0.3 3.14e-8 Alcohol dependence; LUSC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg11871910 chr12:69753446 YEATS4 0.82 14.42 0.62 5.7e-37 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg27001607 chr7:76178636 LOC100133091 -0.46 -6.73 -0.35 7.57e-11 Electrocardiographic conduction measures; LUSC cis rs2282802 0.711 rs3777095 chr5:139660916 G/A cg26211634 chr5:139558579 C5orf32 0.45 8.51 0.42 6.02e-16 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.76e-14 Melanoma; LUSC cis rs7954584 0.567 rs11043246 chr12:122368944 G/A cg13699009 chr12:122356056 WDR66 0.5 7.75 0.39 1.09e-13 Mean corpuscular volume; LUSC cis rs11167764 0.945 rs891991 chr5:141484977 A/T cg23435118 chr5:141488016 NDFIP1 -0.56 -7.79 -0.39 8.56e-14 Crohn's disease; LUSC cis rs12618769 0.597 rs11888595 chr2:99084708 T/G cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs6674970 1.000 rs6676190 chr1:151079317 C/T cg11822372 chr1:151115635 SEMA6C 0.53 8.22 0.41 4.66e-15 Childhood ear infection; LUSC cis rs10986311 0.604 rs10818962 chr9:127182293 C/G cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.39 -6.02 -0.31 4.52e-9 Vitiligo; LUSC cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg23711669 chr6:146136114 FBXO30 0.76 13.47 0.59 2.45e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs7607369 0.536 rs11892469 chr2:219669488 A/T cg02176678 chr2:219576539 TTLL4 -0.52 -9.15 -0.45 5.72e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg23583168 chr7:148888333 NA -0.9 -16.95 -0.68 6.18e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg06637938 chr14:75390232 RPS6KL1 -0.45 -6.89 -0.35 2.84e-11 Height; LUSC cis rs4363385 0.818 rs11205174 chr1:153001230 C/T cg00922841 chr1:152955080 SPRR1A 0.44 7.72 0.39 1.4e-13 Inflammatory skin disease; LUSC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg02569458 chr12:86230093 RASSF9 0.61 10.31 0.49 8.24e-22 Major depressive disorder; LUSC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg17366294 chr4:99064904 C4orf37 0.57 9.96 0.48 1.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9527 0.545 rs10218853 chr10:104796787 A/C cg04362960 chr10:104952993 NT5C2 0.6 9.46 0.46 5.67e-19 Arsenic metabolism; LUSC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08109568 chr15:31115862 NA -0.58 -8.17 -0.41 6.4e-15 Huntington's disease progression; LUSC cis rs453301 0.658 rs9650616 chr8:8869199 T/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.95 -0.4 2.94e-14 Joint mobility (Beighton score); LUSC cis rs1784581 0.722 rs1619122 chr6:162400198 G/T cg17173639 chr6:162384350 PARK2 -0.66 -11.68 -0.54 1.14e-26 Itch intensity from mosquito bite; LUSC cis rs7640424 0.835 rs1561029 chr3:107822245 A/C cg09227934 chr3:107805635 CD47 0.39 6.31 0.33 8.92e-10 Body mass index; LUSC cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg04450456 chr4:17643702 FAM184B -0.41 -6.66 -0.34 1.14e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.32 -5.83 -0.3 1.34e-8 IgG glycosylation; LUSC cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg15423357 chr2:25149977 NA 0.45 9.08 0.44 9.75e-18 Body mass index; LUSC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg06505273 chr16:24850292 NA 0.4 5.8 0.3 1.51e-8 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg03609598 chr5:56110824 MAP3K1 -0.41 -5.74 -0.3 2.14e-8 Initial pursuit acceleration; LUSC cis rs11031096 0.711 rs10767882 chr11:4205841 G/A cg18678763 chr11:4115507 RRM1 -0.41 -5.77 -0.3 1.86e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs28647808 0.881 rs41316982 chr9:136259117 C/T cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.21 -0.49 1.74e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs965604 0.965 rs13180 chr15:78789488 C/T cg18825076 chr15:78729989 IREB2 -0.44 -6.97 -0.36 1.65e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg17173187 chr15:85201210 NMB -0.33 -6.81 -0.35 4.42e-11 P wave terminal force; LUSC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03517284 chr6:25882590 NA -0.46 -7.81 -0.39 7.29e-14 Intelligence (multi-trait analysis); LUSC cis rs9660992 0.512 rs12123773 chr1:205122420 C/G cg21545522 chr1:205238299 TMCC2 0.46 8.69 0.43 1.66e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg06640241 chr16:89574553 SPG7 -0.75 -12.56 -0.57 6.56e-30 Multiple myeloma (IgH translocation); LUSC cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg06784218 chr1:46089804 CCDC17 0.48 9.3 0.45 1.93e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7615952 0.641 rs12495947 chr3:125771698 C/T cg07211511 chr3:129823064 LOC729375 -0.74 -9.59 -0.46 2.12e-19 Blood pressure (smoking interaction); LUSC cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs7582180 0.764 rs4635546 chr2:100921125 G/A cg08017756 chr2:100939284 LONRF2 -0.44 -8.21 -0.41 4.95e-15 Intelligence (multi-trait analysis); LUSC cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg12165864 chr7:66369176 NA -0.54 -7.22 -0.37 3.62e-12 Corneal structure; LUSC cis rs10203711 0.966 rs4998694 chr2:239564713 C/T cg14580085 chr2:239553406 NA 0.41 6.96 0.36 1.76e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs3768617 0.510 rs10911247 chr1:183076993 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.86 0.51 9.81e-24 Fuchs's corneal dystrophy; LUSC cis rs4494114 1.000 rs9439084 chr1:39345017 A/C cg25970120 chr1:39325951 RRAGC -0.41 -6.47 -0.33 3.56e-10 Blood protein levels; LUSC cis rs8179 0.700 rs42043 chr7:92247333 A/G cg15732164 chr7:92237376 CDK6 -0.45 -6.23 -0.32 1.36e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs4409675 0.576 rs6679432 chr1:28227665 T/C cg23691781 chr1:28212827 C1orf38 0.32 7.65 0.39 2.21e-13 Corneal astigmatism; LUSC trans rs9291683 0.588 rs4697705 chr4:10108127 G/A cg26043149 chr18:55253948 FECH -0.51 -7.6 -0.38 2.96e-13 Bone mineral density; LUSC cis rs10992471 0.603 rs1535755 chr9:95202031 G/T cg14631576 chr9:95140430 CENPP -0.36 -6.5 -0.34 2.94e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6964587 1.000 rs2106171 chr7:91750450 A/G cg01689657 chr7:91764605 CYP51A1 0.34 6.19 0.32 1.79e-9 Breast cancer; LUSC cis rs244293 1.000 rs183618 chr17:53235974 C/T cg19360675 chr17:53046073 COX11;STXBP4 0.42 5.98 0.31 5.84e-9 Menarche (age at onset); LUSC cis rs5769765 0.825 rs9616780 chr22:50292763 T/C cg26441486 chr22:50317300 CRELD2 0.52 7.95 0.4 2.85e-14 Schizophrenia; LUSC trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg23505145 chr19:12996616 KLF1 0.65 11.05 0.52 2.17e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs11997175 0.549 rs4349945 chr8:33654323 T/C ch.8.33884649F chr8:33765107 NA 0.52 8.45 0.42 8.95e-16 Body mass index; LUSC cis rs9640161 0.783 rs2021871 chr7:150071156 T/C cg21361702 chr7:150065534 REPIN1 0.59 9.18 0.45 4.49e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg24813613 chr7:1882135 MAD1L1 -0.48 -8.16 -0.41 6.72e-15 Bipolar disorder and schizophrenia; LUSC cis rs4969178 0.896 rs11077361 chr17:76397128 A/G cg05887092 chr17:76393375 PGS1 0.55 9.81 0.47 4.04e-20 HDL cholesterol levels; LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg14004847 chr7:1930337 MAD1L1 -0.53 -8.07 -0.4 1.31e-14 Bipolar disorder and schizophrenia; LUSC trans rs5756813 0.754 rs4821706 chr22:38154690 A/G cg19894588 chr14:64061835 NA -0.58 -7.48 -0.38 6.74e-13 Optic cup area;Vertical cup-disc ratio; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg02475777 chr4:1388615 CRIPAK 0.45 6.86 0.35 3.37e-11 Obesity-related traits; LUSC cis rs61931739 0.517 rs860950 chr12:34104376 C/G cg06521331 chr12:34319734 NA -0.52 -8.62 -0.43 2.69e-16 Morning vs. evening chronotype; LUSC cis rs4692589 0.581 rs62344678 chr4:170961308 G/A cg19918862 chr4:170955249 NA 0.35 6.45 0.33 3.87e-10 Anxiety disorder; LUSC cis rs73198271 0.530 rs113160067 chr8:8654521 A/C cg01851573 chr8:8652454 MFHAS1 0.61 8.32 0.41 2.24e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs7659604 0.643 rs6839054 chr4:122663628 C/T cg19748678 chr4:122722346 EXOSC9 0.49 6.7 0.34 8.97e-11 Type 2 diabetes; LUSC cis rs3020736 0.500 rs4147640 chr22:42485292 T/C cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs7246967 0.611 rs12983761 chr19:22840597 C/A cg23217946 chr19:22817039 ZNF492 0.45 6.04 0.31 4.09e-9 Bronchopulmonary dysplasia; LUSC cis rs1997103 1.000 rs4947501 chr7:55407342 C/T cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg15031826 chr1:208136952 NA 0.41 6.12 0.32 2.59e-9 N-glycan levels; LUSC trans rs1040 0.646 rs6605528 chr6:169608807 A/C cg08069338 chr6:160207898 SNORA29;TCP1 0.36 6.03 0.31 4.37e-9 Joint mobility (Beighton score); LUSC cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.46 -0.42 8.29e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.54 0.46 3.02e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg08392591 chr16:89556376 ANKRD11 0.47 7.09 0.36 8.07e-12 Multiple myeloma (IgH translocation); LUSC cis rs6912958 0.712 rs2307379 chr6:88366771 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.91 -0.35 2.39e-11 Monocyte percentage of white cells; LUSC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg09509183 chr1:209979624 IRF6 -0.42 -5.68 -0.3 2.99e-8 Cleft lip with or without cleft palate; LUSC cis rs73206853 0.620 rs17682644 chr12:111156008 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.77 0.35 5.7e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs13314892 1.000 rs13314892 chr3:69795052 A/G cg16641818 chr10:45869619 ALOX5 0.42 5.97 0.31 6.23e-9 QRS complex (12-leadsum); LUSC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -6.9 -0.35 2.56e-11 Bipolar disorder; LUSC cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.81 0.35 4.44e-11 Rheumatoid arthritis; LUSC trans rs7829975 0.567 rs6601273 chr8:8796519 T/G cg21775007 chr8:11205619 TDH -0.41 -6.22 -0.32 1.52e-9 Mood instability; LUSC cis rs737008 0.922 rs11074957 chr16:11378151 G/A cg00044050 chr16:11439710 C16orf75 -0.52 -8.03 -0.4 1.64e-14 Obesity-related traits; LUSC trans rs4927850 1.000 rs4927850 chr3:195751630 C/T cg21051086 chr3:73046214 PPP4R2 0.53 8.07 0.4 1.26e-14 Pancreatic cancer; LUSC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.08 -0.32 3.23e-9 Life satisfaction; LUSC cis rs9467711 0.591 rs13195692 chr6:26044373 C/T cg16898833 chr6:26189333 HIST1H4D 0.63 5.96 0.31 6.36e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs10905065 0.965 rs10795520 chr10:5764160 G/A cg11519256 chr10:5708881 ASB13 0.4 5.83 0.3 1.34e-8 Menopause (age at onset); LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg16362232 chr11:430036 ANO9 0.61 7.96 0.4 2.63e-14 Body mass index; LUSC trans rs1005277 0.683 rs7923868 chr10:37989766 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -6.14 -0.32 2.3e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg23711669 chr6:146136114 FBXO30 0.75 13.26 0.59 1.61e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs6598955 0.671 rs58038522 chr1:26582713 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.65 0.6 5.26e-34 Alzheimer's disease; LUSC trans rs2243480 1.000 rs10807701 chr7:65724686 C/A cg10756647 chr7:56101905 PSPH -0.87 -8.68 -0.43 1.74e-16 Diabetic kidney disease; LUSC cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg06784218 chr1:46089804 CCDC17 0.47 9.27 0.45 2.3e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8114671 0.836 rs62213676 chr20:33612676 T/A cg07148914 chr20:33460835 GGT7 -0.45 -6.67 -0.34 1.07e-10 Height; LUSC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 8.75 0.43 1.06e-16 Hip circumference adjusted for BMI; LUSC cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg08999081 chr20:33150536 PIGU 0.43 7.9 0.4 4.06e-14 Coronary artery disease; LUSC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.74 0.35 6.99e-11 Intelligence (multi-trait analysis); LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg15147215 chr3:52552868 STAB1 -0.32 -6.34 -0.33 7.29e-10 Electroencephalogram traits; LUSC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs13315871 0.790 rs28502788 chr3:58296208 A/T cg20936604 chr3:58311152 NA -0.67 -6.59 -0.34 1.69e-10 Cholesterol, total; LUSC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg03289416 chr15:75166202 SCAMP2 0.44 6.68 0.34 9.94e-11 Breast cancer; LUSC cis rs2227564 0.620 rs11000765 chr10:75512452 G/C cg23231163 chr10:75533350 FUT11 -0.45 -6.52 -0.34 2.63e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs983392 0.631 rs7107627 chr11:60041296 T/A cg02771260 chr11:59836817 MS4A3 0.36 5.89 0.31 9.17e-9 Alzheimer's disease (late onset); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg02999463 chr8:37707322 BRF2 -0.41 -6.19 -0.32 1.73e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4631830 0.863 rs4935162 chr10:51525699 C/G cg20129853 chr10:51489980 NA -0.34 -7.04 -0.36 1.11e-11 Prostate-specific antigen levels; LUSC cis rs80130819 0.688 rs7313023 chr12:48584179 T/C cg24011408 chr12:48396354 COL2A1 0.44 5.67 0.3 3.1e-8 Prostate cancer; LUSC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg11366901 chr6:160182831 ACAT2 0.92 13.16 0.58 3.76e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg01802117 chr1:53393560 SCP2 0.41 6.88 0.35 2.89e-11 Monocyte count; LUSC cis rs7520050 0.751 rs2230657 chr1:46073489 G/A cg24296786 chr1:45957014 TESK2 0.43 5.93 0.31 7.68e-9 Red blood cell count;Reticulocyte count; LUSC cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11650494 0.908 rs111834333 chr17:47411814 C/T cg08112188 chr17:47440006 ZNF652 1.16 9.74 0.47 6.89e-20 Prostate cancer; LUSC cis rs2439831 0.867 rs6493082 chr15:43634808 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC trans rs8072100 0.967 rs3760370 chr17:45695832 C/T cg03886242 chr7:26192032 NFE2L3 0.37 6.27 0.32 1.12e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6681460 0.649 rs1338184 chr1:67005072 C/T cg02459107 chr1:67143332 SGIP1 -0.36 -6.15 -0.32 2.17e-9 Presence of antiphospholipid antibodies; LUSC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg22467129 chr15:76604101 ETFA 0.52 8.78 0.43 8.41e-17 Blood metabolite levels; LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6541297 0.941 rs6693579 chr1:230282707 T/C cg20703242 chr1:230279135 GALNT2 0.57 7.17 0.37 4.92e-12 Coronary artery disease; LUSC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg22508957 chr16:3507546 NAT15 -0.41 -6.52 -0.34 2.67e-10 Body mass index (adult); LUSC cis rs12472274 0.646 rs10929269 chr2:239097423 A/G cg17459225 chr2:239074497 NA 0.54 7.41 0.38 1.06e-12 Phospholipid levels (plasma); LUSC cis rs394563 0.591 rs237019 chr6:149727064 G/A cg03678062 chr6:149772716 ZC3H12D -0.32 -6.54 -0.34 2.32e-10 Dupuytren's disease; LUSC cis rs3020736 0.500 rs11090076 chr22:42514190 T/C cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs6500395 0.926 rs1120275 chr16:48598737 T/G cg04672837 chr16:48644449 N4BP1 0.43 6.17 0.32 1.94e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg26513180 chr16:89883248 FANCA 0.9 17.39 0.69 1.12e-48 Vitiligo; LUSC cis rs559928 0.556 rs11607903 chr11:63932140 G/A cg24687543 chr11:63912206 MACROD1 0.47 5.82 0.3 1.4e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 13.65 0.6 4.99e-34 Platelet count; LUSC cis rs7927592 0.913 rs7925275 chr11:68290433 T/C cg20283391 chr11:68216788 NA -0.61 -8.53 -0.42 5.12e-16 Total body bone mineral density; LUSC cis rs9303542 0.559 rs2229302 chr17:46620402 G/A cg09704116 chr17:46666958 LOC404266 -0.39 -6.58 -0.34 1.85e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg18132916 chr6:79620363 NA -0.38 -5.84 -0.3 1.23e-8 Intelligence (multi-trait analysis); LUSC cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg15485101 chr11:133734466 NA 0.4 7.2 0.37 4.13e-12 Childhood ear infection; LUSC cis rs11122272 0.735 rs2739516 chr1:231505527 G/A cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs6543140 0.601 rs6543135 chr2:103062406 C/T cg09003973 chr2:102972529 NA 0.71 8.31 0.41 2.51e-15 Blood protein levels; LUSC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.74 0.51 2.64e-23 Homoarginine levels; LUSC cis rs6120849 0.707 rs3746448 chr20:33572979 C/T cg24642439 chr20:33292090 TP53INP2 0.58 5.94 0.31 7.17e-9 Protein C levels; LUSC cis rs2991971 1.000 rs606542 chr1:46013933 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.46 -0.33 3.73e-10 High light scatter reticulocyte count; LUSC cis rs7647973 1.000 rs56127630 chr3:49438036 C/G cg07636037 chr3:49044803 WDR6 -0.69 -9.17 -0.45 4.8e-18 Menarche (age at onset); LUSC trans rs7137301 0.895 rs10842526 chr12:25447753 A/G cg04849298 chr8:142309389 NA -0.38 -6.0 -0.31 5.12e-9 Dysmenorrheic pain; LUSC cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg14844989 chr11:31128820 NA -0.37 -5.74 -0.3 2.1e-8 Red blood cell count; LUSC cis rs6424115 1.000 rs2179395 chr1:24148365 T/C cg15997130 chr1:24165203 NA 0.57 9.21 0.45 3.7e-18 Immature fraction of reticulocytes; LUSC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg13683864 chr3:40499215 RPL14 -1.16 -21.22 -0.76 7.21e-64 Renal cell carcinoma; LUSC cis rs950169 0.580 rs35516100 chr15:85195430 C/T cg17507749 chr15:85114479 UBE2QP1 0.59 7.51 0.38 5.32e-13 Schizophrenia; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg13560548 chr3:10150139 C3orf24 0.55 7.37 0.37 1.33e-12 Alzheimer's disease; LUSC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg22800045 chr5:56110881 MAP3K1 0.67 9.13 0.45 6.52e-18 Initial pursuit acceleration; LUSC cis rs76878669 0.561 rs905770 chr11:66156765 A/G cg24851651 chr11:66362959 CCS -0.37 -5.84 -0.3 1.26e-8 Educational attainment (years of education); LUSC cis rs1065656 0.589 rs391543 chr16:1915583 T/G cg00564555 chr16:1970112 NA 0.37 6.26 0.32 1.2e-9 Insulin-like growth factors; LUSC cis rs7267979 1.000 rs6037105 chr20:25374199 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.97 -0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs79349575 0.721 rs3744608 chr17:46993233 C/G cg22482690 chr17:47019901 SNF8 0.4 7.64 0.39 2.33e-13 Type 2 diabetes; LUSC cis rs11098499 0.739 rs4833612 chr4:120147596 A/C cg09307838 chr4:120376055 NA -0.6 -8.85 -0.44 5.24e-17 Corneal astigmatism; LUSC cis rs1348850 0.914 rs2121430 chr2:178318375 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.66 0.39 2.06e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs500891 1.000 rs62419351 chr6:84192228 C/G cg08257003 chr6:84140564 ME1 0.34 7.06 0.36 9.77e-12 Platelet-derived growth factor BB levels; LUSC cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg22563815 chr15:78856949 CHRNA5 -0.25 -6.03 -0.31 4.45e-9 Sudden cardiac arrest; LUSC cis rs62408225 1.000 rs969577 chr6:90982387 T/C cg06866423 chr6:90926672 BACH2 0.42 5.98 0.31 5.77e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1163251 0.902 rs839605 chr1:120217524 C/A cg19096424 chr1:120255104 PHGDH 0.48 6.53 0.34 2.39e-10 Blood metabolite levels; LUSC trans rs72674100 1.000 rs4075858 chr4:97991815 A/G cg00855990 chr1:18959354 PAX7 0.59 5.95 0.31 6.74e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7818345 0.967 rs6990357 chr8:19276681 C/G cg11303988 chr8:19266685 CSGALNACT1 0.39 7.47 0.38 6.9e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs473651 0.935 rs558924 chr2:239339511 A/G cg08773314 chr2:239334832 ASB1 0.37 6.91 0.35 2.51e-11 Multiple system atrophy; LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.83 -0.3 1.33e-8 Platelet count; LUSC cis rs10740039 0.804 rs4948424 chr10:62441570 C/T cg18175470 chr10:62150864 ANK3 -0.45 -6.7 -0.34 8.84e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2970818 0.831 rs11063207 chr12:4603698 A/G cg11146114 chr12:4671731 NA -0.56 -5.92 -0.31 7.87e-9 Phosphorus levels; LUSC cis rs977987 0.778 rs11149825 chr16:75434878 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.85 -0.35 3.56e-11 Dupuytren's disease; LUSC cis rs7927592 0.913 rs10896338 chr11:68299360 G/A cg16797656 chr11:68205561 LRP5 0.38 6.25 0.32 1.27e-9 Total body bone mineral density; LUSC cis rs2839186 0.814 rs2276257 chr21:47711229 A/G cg11766577 chr21:47581405 C21orf56 -0.42 -6.21 -0.32 1.53e-9 Testicular germ cell tumor; LUSC cis rs4566357 0.576 rs6750845 chr2:227911037 T/G cg11843606 chr2:227700838 RHBDD1 -0.54 -8.3 -0.41 2.67e-15 Coronary artery disease; LUSC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg12442385 chr7:1034912 NA -0.34 -5.81 -0.3 1.42e-8 Longevity;Endometriosis; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg20295408 chr7:1910781 MAD1L1 -0.48 -6.71 -0.34 8.39e-11 Bipolar disorder and schizophrenia; LUSC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg26818010 chr10:134567672 INPP5A -0.87 -11.03 -0.52 2.41e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs6964587 1.000 rs415 chr7:91580490 A/G cg01689657 chr7:91764605 CYP51A1 -0.34 -6.05 -0.31 3.81e-9 Breast cancer; LUSC cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.77e-30 Motion sickness; LUSC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg14500267 chr11:67383377 NA 0.44 8.94 0.44 2.79e-17 Mean corpuscular volume; LUSC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg25456477 chr12:86230367 RASSF9 0.44 7.88 0.4 4.75e-14 Major depressive disorder; LUSC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg14019146 chr3:50243930 SLC38A3 0.36 8.42 0.42 1.12e-15 Body mass index; LUSC cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg27129171 chr3:47204927 SETD2 -0.7 -11.68 -0.54 1.15e-26 Colorectal cancer; LUSC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.41 6.32 0.33 8.51e-10 Parkinson's disease; LUSC cis rs559928 0.606 rs56311067 chr11:63931607 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 7.25 0.37 2.93e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6546550 0.867 rs1551374 chr2:70079633 C/T cg02498382 chr2:70120550 SNRNP27 -0.31 -7.46 -0.38 7.68e-13 Prevalent atrial fibrillation; LUSC cis rs2224391 0.628 rs2753240 chr6:5254124 T/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.51 -6.87 -0.35 3.12e-11 Height; LUSC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg18404041 chr3:52824283 ITIH1 -0.57 -10.8 -0.51 1.62e-23 Bipolar disorder; LUSC cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg15423357 chr2:25149977 NA 0.41 8.15 0.41 7.16e-15 Body mass index; LUSC cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg06454157 chr6:167490870 NA -0.26 -6.29 -0.33 9.76e-10 Crohn's disease; LUSC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.29 0.33 9.99e-10 Menopause (age at onset); LUSC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg22907277 chr7:1156413 C7orf50 0.72 10.44 0.5 2.92e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg05623727 chr3:50126028 RBM5 -0.33 -6.14 -0.32 2.32e-9 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.48 -6.95 -0.36 1.95e-11 Menarche (age at onset); LUSC cis rs977987 0.788 rs7184525 chr16:75437186 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.79e-10 Dupuytren's disease; LUSC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.43 -0.38 9.09e-13 Developmental language disorder (linguistic errors); LUSC trans rs877282 0.842 rs12357963 chr10:757562 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.51 -0.34 2.71e-10 Uric acid levels; LUSC cis rs1499972 0.941 rs62263121 chr3:117630348 T/C cg07612923 chr3:117604196 NA 0.64 5.76 0.3 1.95e-8 Schizophrenia; LUSC cis rs7605827 0.866 rs4668917 chr2:15661815 G/C cg19274914 chr2:15703543 NA 0.47 9.19 0.45 4.24e-18 Educational attainment (years of education); LUSC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg05425664 chr17:57184151 TRIM37 -0.56 -8.28 -0.41 2.93e-15 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg18876405 chr7:65276391 NA 0.55 8.81 0.43 6.74e-17 Aortic root size; LUSC cis rs8062405 0.755 rs12447461 chr16:28582941 C/A cg07382826 chr16:28625726 SULT1A1 0.27 5.82 0.3 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg14965968 chr3:44803235 KIF15;KIAA1143 0.5 6.11 0.32 2.72e-9 Allergic disease (asthma, hay fever or eczema); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10573403 chr14:36003118 INSM2 0.5 6.88 0.35 3.05e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg17724175 chr1:150552817 MCL1 0.37 6.77 0.35 5.97e-11 Tonsillectomy; LUSC cis rs459571 0.959 rs456205 chr9:136911146 G/A cg13789015 chr9:136890014 NCRNA00094 0.7 12.84 0.57 6.14e-31 Platelet distribution width; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.61 0.34 1.5e-10 Menopause (age at onset); LUSC cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.74 -9.95 -0.48 1.36e-20 Chronic sinus infection; LUSC cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg16797656 chr11:68205561 LRP5 0.36 6.05 0.31 3.86e-9 Total body bone mineral density; LUSC cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.52 -6.92 -0.35 2.25e-11 Alzheimer's disease (late onset); LUSC cis rs10489202 1.000 rs34192847 chr1:168064317 A/T cg24449463 chr1:168025552 DCAF6 -0.58 -7.09 -0.36 7.9e-12 Schizophrenia; LUSC cis rs41271473 0.898 rs72750015 chr1:228811318 A/G cg10167378 chr1:228756711 NA 0.58 7.14 0.36 5.77e-12 Chronic lymphocytic leukemia; LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.89 0.55 2.01e-27 Prudent dietary pattern; LUSC cis rs9341835 0.740 rs4710255 chr6:64156268 A/C cg03326410 chr6:64151739 NA -0.37 -5.98 -0.31 5.76e-9 Schizophrenia; LUSC cis rs11785693 0.862 rs62491189 chr8:4991309 T/C cg26367366 chr8:4980734 NA 0.8 9.4 0.46 8.78e-19 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs7584330 0.554 rs77956735 chr2:238399130 C/T cg14458575 chr2:238380390 NA 0.71 8.53 0.42 5.04e-16 Prostate cancer; LUSC cis rs11864453 0.647 rs3852781 chr16:72123556 T/A cg16558253 chr16:72132732 DHX38 -0.37 -5.76 -0.3 1.86e-8 Fibrinogen levels; LUSC cis rs12286929 0.610 rs12807135 chr11:115053508 G/C cg04055981 chr11:115044050 NA 0.43 7.83 0.39 6.53e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg11663144 chr21:46675770 NA 0.39 6.21 0.32 1.61e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11637445 0.627 rs4776988 chr15:68124151 C/T cg08079166 chr15:68083412 MAP2K5 0.32 6.55 0.34 2.2e-10 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs427941 0.632 rs201500 chr7:101757806 G/C cg06246474 chr7:101738831 CUX1 0.39 6.36 0.33 6.54e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.11e-14 Glomerular filtration rate (creatinine); LUSC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg02807482 chr3:125708958 NA -0.52 -6.51 -0.34 2.69e-10 Blood pressure (smoking interaction); LUSC cis rs6977940 0.818 rs73033479 chr7:2905499 G/A cg19731401 chr7:2775893 GNA12 0.67 7.7 0.39 1.56e-13 White matter integrity; LUSC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg23205692 chr1:25664452 TMEM50A 0.44 6.72 0.34 8.08e-11 Erythrocyte sedimentation rate; LUSC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg04362960 chr10:104952993 NT5C2 0.52 7.59 0.38 3.17e-13 Immature fraction of reticulocytes;Schizophrenia; LUSC trans rs17807624 0.780 rs13277929 chr8:11453030 G/A cg06636001 chr8:8085503 FLJ10661 0.44 6.18 0.32 1.92e-9 Systemic lupus erythematosus; LUSC cis rs4843185 0.516 rs374029 chr16:85725953 G/A cg26571870 chr16:85723150 GINS2 -0.34 -6.31 -0.33 8.93e-10 Platelet distribution width; LUSC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs68170813 0.559 rs10953534 chr7:106913718 A/G cg02696742 chr7:106810147 HBP1 0.61 9.11 0.45 7.93e-18 Coronary artery disease; LUSC cis rs2073300 1.000 rs6114139 chr20:23458390 T/G cg09953122 chr20:23471693 CST8 -0.69 -6.84 -0.35 3.84e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg20887711 chr4:1340912 KIAA1530 -0.47 -7.24 -0.37 3.1e-12 Obesity-related traits; LUSC cis rs4654899 1.000 rs7525438 chr1:21458217 G/A cg01072550 chr1:21505969 NA -0.55 -8.41 -0.42 1.18e-15 Superior frontal gyrus grey matter volume; LUSC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg01879757 chr17:41196368 BRCA1 0.4 5.99 0.31 5.32e-9 Menopause (age at onset); LUSC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12756686 chr19:29218302 NA 0.67 9.52 0.46 3.67e-19 Methadone dose in opioid dependence; LUSC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg25039879 chr17:56429692 SUPT4H1 0.41 5.91 0.31 8.31e-9 Cognitive test performance; LUSC cis rs2797160 0.515 rs4897149 chr6:125980018 G/T cg05901451 chr6:126070800 HEY2 0.41 5.94 0.31 7.1e-9 Endometrial cancer; LUSC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg08847533 chr14:75593920 NEK9 -0.84 -15.5 -0.65 3.28e-41 Height; LUSC cis rs10761482 0.701 rs7087958 chr10:62121891 G/A cg18175470 chr10:62150864 ANK3 -0.41 -6.16 -0.32 2.15e-9 Schizophrenia; LUSC cis rs10876993 0.728 rs1082503 chr12:58036717 G/A cg18357645 chr12:58087776 OS9 0.49 7.34 0.37 1.65e-12 Celiac disease or Rheumatoid arthritis; LUSC trans rs3733585 0.637 rs6850684 chr4:9964380 G/T cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg27572855 chr1:25598939 RHD 0.44 7.82 0.39 6.94e-14 Erythrocyte sedimentation rate; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg16606324 chr3:10149918 C3orf24 0.62 8.42 0.42 1.16e-15 Alzheimer's disease; LUSC cis rs400736 0.562 rs7551900 chr1:8178526 A/C cg25007680 chr1:8021821 PARK7 -0.43 -6.16 -0.32 2.08e-9 Response to antidepressants and depression; LUSC cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.54 0.65 2.22e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg20404643 chr11:1492543 HCCA2 -0.39 -6.25 -0.32 1.28e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4820539 0.933 rs2267004 chr22:23459863 G/A cg21100191 chr22:23484243 RTDR1 0.86 14.42 0.62 5.5e-37 Bone mineral density; LUSC cis rs7614311 0.681 rs73130565 chr3:63887135 T/C cg22134162 chr3:63841271 THOC7 -0.48 -6.13 -0.32 2.43e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs3806843 0.735 rs3776129 chr5:140072292 G/A cg26395211 chr5:140044315 WDR55 0.45 6.99 0.36 1.5e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg21573476 chr21:45109991 RRP1B -0.41 -6.66 -0.34 1.11e-10 Mean corpuscular volume; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg06569271 chr3:186501246 EIF4A2;SNORD2 -0.4 -6.18 -0.32 1.9e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs796364 0.762 rs13030712 chr2:200973569 G/A cg23649088 chr2:200775458 C2orf69 0.61 9.28 0.45 2.28e-18 Schizophrenia; LUSC cis rs926938 0.584 rs1299780 chr1:115366014 G/A cg12756093 chr1:115239321 AMPD1 0.53 8.05 0.4 1.44e-14 Autism; LUSC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg16362232 chr11:430036 ANO9 0.62 7.81 0.39 7.41e-14 Body mass index; LUSC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg20203395 chr5:56204925 C5orf35 0.55 8.02 0.4 1.86e-14 Initial pursuit acceleration; LUSC cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg07424592 chr7:64974309 NA 0.7 6.2 0.32 1.67e-9 Diabetic kidney disease; LUSC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.02 0.31 4.59e-9 Menopause (age at onset); LUSC cis rs7296418 0.630 rs28419092 chr12:123812629 G/C cg00376283 chr12:123451042 ABCB9 0.71 10.93 0.51 5.64e-24 Platelet count; LUSC cis rs10927875 0.662 rs848309 chr1:16308447 T/C cg22431228 chr1:16359049 CLCNKA -0.47 -10.12 -0.48 3.57e-21 Dilated cardiomyopathy; LUSC cis rs4792901 0.918 rs76798487 chr17:41633391 A/G cg22562494 chr17:41607896 ETV4 -0.29 -5.73 -0.3 2.3e-8 Dupuytren's disease; LUSC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg23625390 chr15:77176239 SCAPER -0.5 -7.79 -0.39 8.74e-14 Blood metabolite levels; LUSC cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg03146154 chr1:46216737 IPP 0.54 8.25 0.41 3.79e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.15 -0.32 2.18e-9 Developmental language disorder (linguistic errors); LUSC cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg19875535 chr5:140030758 IK 0.52 8.57 0.42 3.89e-16 Depressive symptoms (multi-trait analysis); LUSC cis rs11030122 0.673 rs11030639 chr11:4039056 A/G cg18678763 chr11:4115507 RRM1 -0.42 -5.65 -0.3 3.52e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.78 0.35 5.5e-11 Platelet count; LUSC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg26441486 chr22:50317300 CRELD2 0.45 6.8 0.35 4.81e-11 Schizophrenia; LUSC cis rs4555082 1.000 rs7149013 chr14:105759840 T/C cg06808227 chr14:105710500 BRF1 -0.64 -9.22 -0.45 3.34e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs9815354 0.680 rs79211428 chr3:41921810 C/T cg03022575 chr3:42003672 ULK4 0.71 7.52 0.38 5.17e-13 Pulse pressure;Diastolic blood pressure; LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.89 0.31 9.52e-9 Menopause (age at onset); LUSC cis rs72781680 0.848 rs715646 chr2:24010566 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg10018233 chr7:150070692 REPIN1 0.37 6.48 0.33 3.37e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs250677 0.522 rs1432801 chr5:148390979 T/C cg18129178 chr5:148520854 ABLIM3 -0.54 -7.72 -0.39 1.34e-13 Breast cancer; LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03934478 chr11:495069 RNH1 0.79 9.53 0.46 3.34e-19 Body mass index; LUSC cis rs9467773 0.620 rs2451741 chr6:26629404 A/G cg09904177 chr6:26538194 HMGN4 0.66 11.71 0.54 9.14e-27 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11890956 chr21:40555474 PSMG1 1.03 21.0 0.75 5.38e-63 Cognitive function; LUSC cis rs929354 1.000 rs1182377 chr7:157048403 T/C cg17757837 chr7:157058334 UBE3C -0.93 -15.85 -0.66 1.45e-42 Body mass index; LUSC cis rs992157 0.965 rs13427681 chr2:219167563 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.55 8.47 0.42 8.12e-16 Colorectal cancer; LUSC cis rs2836633 0.859 rs8132069 chr21:40032611 T/C cg12884169 chr21:40033163 ERG 0.61 12.48 0.56 1.35e-29 Coronary artery disease; LUSC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg10609677 chr17:41278573 BRCA1;NBR2 0.36 5.86 0.31 1.09e-8 Menopause (age at onset); LUSC cis rs9807841 0.592 rs11085743 chr19:10759442 G/A cg09936142 chr19:10668400 KRI1 -0.41 -6.71 -0.34 8.59e-11 Inflammatory skin disease; LUSC cis rs7589342 0.509 rs10177819 chr2:106386640 G/A cg09152813 chr2:106391379 NCK2 -0.37 -6.14 -0.32 2.32e-9 Addiction; LUSC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg10792982 chr14:105748885 BRF1 0.47 8.3 0.41 2.56e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg16586182 chr3:47516702 SCAP -0.45 -6.36 -0.33 6.68e-10 Birth weight; LUSC cis rs13108904 0.870 rs2335855 chr4:1237968 T/C cg20887711 chr4:1340912 KIAA1530 0.41 6.16 0.32 2.15e-9 Obesity-related traits; LUSC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18099408 chr3:52552593 STAB1 -0.41 -7.2 -0.37 3.9e-12 Bipolar disorder; LUSC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg09365446 chr1:150670422 GOLPH3L -0.56 -8.7 -0.43 1.55e-16 Tonsillectomy; LUSC cis rs9399135 0.967 rs9389251 chr6:135325717 A/G cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Red blood cell count; LUSC cis rs1577917 0.916 rs12203358 chr6:86603224 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.84 -0.44 5.46e-17 Response to antipsychotic treatment; LUSC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg16325326 chr1:53192061 ZYG11B -1.0 -20.85 -0.75 1.94e-62 Monocyte count; LUSC cis rs17253792 0.915 rs75862063 chr14:56177769 G/T cg01858014 chr14:56050164 KTN1 -0.85 -6.86 -0.35 3.35e-11 Putamen volume; LUSC cis rs4947962 0.618 rs59119563 chr7:55090048 T/C cg23757825 chr7:55092271 EGFR -0.65 -8.39 -0.42 1.42e-15 Subjective response to lithium treatment; LUSC cis rs9287719 0.967 rs4669593 chr2:10701908 C/T cg00105475 chr2:10696890 NA 0.37 6.12 0.32 2.55e-9 Prostate cancer; LUSC cis rs7258465 1.000 rs271623 chr19:18628947 A/G cg11102782 chr19:18549136 ISYNA1 -0.32 -5.97 -0.31 6.12e-9 Breast cancer; LUSC cis rs6750047 0.771 rs1056837 chr2:38298150 A/G cg07380506 chr2:38303506 CYP1B1 0.44 6.09 0.32 3.12e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs56399783 0.901 rs73051415 chr7:2850643 C/T cg19731401 chr7:2775893 GNA12 0.71 9.73 0.47 7.3e-20 Childhood ear infection; LUSC cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg00071950 chr4:10020882 SLC2A9 0.61 10.08 0.48 5.02e-21 Bone mineral density; LUSC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.47e-9 Bipolar disorder; LUSC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg08847533 chr14:75593920 NEK9 -0.82 -13.49 -0.59 2.04e-33 Height; LUSC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.82 0.78 4.1e-70 Prudent dietary pattern; LUSC cis rs7100689 0.784 rs10736342 chr10:82130005 A/G cg01528321 chr10:82214614 TSPAN14 1.03 15.99 0.66 3.98e-43 Post bronchodilator FEV1; LUSC cis rs9952991 0.883 rs2542147 chr18:12775851 G/T cg23598886 chr18:12777645 NA 0.65 6.58 0.34 1.83e-10 Inflammatory skin disease; LUSC cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg12935359 chr14:103987150 CKB -0.52 -8.07 -0.4 1.26e-14 Body mass index; LUSC trans rs7615952 0.688 rs17334074 chr3:125540460 A/G cg07211511 chr3:129823064 LOC729375 0.96 13.42 0.59 3.86e-33 Blood pressure (smoking interaction); LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg22868518 chr11:507468 RNH1 -0.63 -6.2 -0.32 1.69e-9 Body mass index; LUSC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg02423579 chr7:2872169 GNA12 -0.39 -5.81 -0.3 1.43e-8 Height; LUSC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.88 8.25 0.41 3.68e-15 Lung cancer in ever smokers; LUSC cis rs9300255 0.722 rs12322888 chr12:123825559 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -5.9 -0.31 8.85e-9 Neutrophil percentage of white cells; LUSC cis rs524023 0.914 rs2360872 chr11:64353405 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.15 -0.49 2.86e-21 Urate levels in obese individuals; LUSC cis rs34375054 0.525 rs1080910 chr12:125608492 T/C cg02766259 chr12:125626809 AACS -0.3 -5.75 -0.3 2.04e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6547741 1.000 rs6756238 chr2:27841305 G/A cg12559939 chr2:27858050 GPN1 0.41 6.48 0.33 3.32e-10 Oral cavity cancer; LUSC cis rs1003719 0.646 rs2835671 chr21:38581125 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.18 -0.49 2.18e-21 Eye color traits; LUSC cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg01849466 chr14:104193079 ZFYVE21 -0.49 -7.58 -0.38 3.37e-13 Schizophrenia; LUSC cis rs2806561 0.929 rs2867315 chr1:23541286 C/T cg19743168 chr1:23544995 NA -0.46 -10.03 -0.48 7.03e-21 Height; LUSC cis rs1691799 0.867 rs1168330 chr12:66763167 C/T cg16791601 chr12:66731901 HELB 0.67 11.39 0.53 1.28e-25 White blood cell count (basophil); LUSC cis rs6545883 0.929 rs2264100 chr2:61670829 G/A cg15711740 chr2:61764176 XPO1 -0.46 -7.11 -0.36 7.17e-12 Tuberculosis; LUSC cis rs701145 0.585 rs1727920 chr3:153788588 C/T cg17054900 chr3:154042577 DHX36 0.72 7.26 0.37 2.82e-12 Coronary artery disease; LUSC trans rs853679 0.607 rs13199772 chr6:27834085 A/G cg06606381 chr12:133084897 FBRSL1 -1.02 -9.08 -0.44 9.93e-18 Depression; LUSC cis rs4319547 0.695 rs1973463 chr12:122938003 A/G cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.01 -0.4 1.95e-14 Body mass index; LUSC cis rs425277 0.628 rs3107145 chr1:2047547 G/A cg04315214 chr1:2043799 PRKCZ 0.5 10.5 0.5 1.78e-22 Height; LUSC cis rs1559088 0.847 rs8110181 chr19:33605939 G/A cg17764715 chr19:33622953 WDR88 0.62 8.47 0.42 8.16e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg00321850 chr1:175162397 KIAA0040 0.46 7.98 0.4 2.36e-14 Alcohol dependence; LUSC cis rs1113500 0.933 rs3893034 chr1:108632178 G/A cg06207961 chr1:108661230 NA 0.4 7.45 0.38 8.2e-13 Growth-regulated protein alpha levels; LUSC cis rs6445797 0.632 rs9985253 chr3:56629250 G/C cg13792233 chr3:56591045 CCDC66 0.39 5.64 0.3 3.55e-8 Gastritis; LUSC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg22907277 chr7:1156413 C7orf50 0.67 7.95 0.4 2.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs877282 0.898 rs35743076 chr10:758991 C/T cg22713356 chr15:30763199 NA 0.98 13.65 0.6 5.18e-34 Uric acid levels; LUSC cis rs3008870 0.958 rs34367328 chr1:67445321 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -15.35 -0.64 1.33e-40 Lymphocyte percentage of white cells; LUSC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg13206674 chr6:150067644 NUP43 0.61 9.84 0.47 3.07e-20 Lung cancer; LUSC cis rs1790761 0.554 rs3758938 chr11:67402362 T/G cg24690094 chr11:67383802 NA -0.45 -8.09 -0.4 1.11e-14 Mean corpuscular volume; LUSC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg26380479 chr7:97908229 NA -0.27 -5.9 -0.31 8.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6087990 0.735 rs2065576 chr20:31389009 C/T cg13636640 chr20:31349939 DNMT3B 0.92 18.94 0.72 7.43e-55 Ulcerative colitis; LUSC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg12463550 chr7:65579703 CRCP -0.49 -7.03 -0.36 1.19e-11 Aortic root size; LUSC cis rs4588572 0.644 rs10942856 chr5:77746199 A/G cg11547950 chr5:77652471 NA 0.49 7.23 0.37 3.4e-12 Triglycerides; LUSC cis rs2548003 0.518 rs1157974 chr5:28765229 C/T cg22863700 chr5:28928346 NA -0.44 -6.28 -0.32 1.07e-9 Hip geometry; LUSC cis rs2652822 0.935 rs12148069 chr15:63443792 A/T cg02713581 chr15:63449717 RPS27L 0.43 6.74 0.35 7.07e-11 Metabolic traits; LUSC cis rs4363385 0.693 rs821755 chr1:153036245 G/C cg00922841 chr1:152955080 SPRR1A -0.42 -7.2 -0.37 4.13e-12 Inflammatory skin disease; LUSC cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg05347473 chr6:146136440 FBXO30 -0.49 -8.29 -0.41 2.72e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.632 rs135871 chr22:50008969 A/G cg05373962 chr22:49881684 NA -0.4 -8.38 -0.42 1.49e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg21280719 chr6:42927975 GNMT -0.31 -7.84 -0.39 6.14e-14 Plasma homocysteine levels (post-methionine load test); LUSC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg20503657 chr10:835505 NA 0.98 13.49 0.59 2.03e-33 Eosinophil percentage of granulocytes; LUSC cis rs11190604 0.767 rs10883478 chr10:102162852 C/T cg07080220 chr10:102295463 HIF1AN 0.58 7.59 0.38 3.1400000000000003e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg15147215 chr3:52552868 STAB1 -0.3 -5.84 -0.3 1.22e-8 Electroencephalogram traits; LUSC cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg13010199 chr12:38710504 ALG10B -0.66 -10.08 -0.48 5.02e-21 Bladder cancer; LUSC cis rs965469 0.895 rs6051841 chr20:3392871 A/G cg25506879 chr20:3388711 C20orf194 -0.54 -5.79 -0.3 1.66e-8 IFN-related cytopenia; LUSC cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg12437481 chr16:420112 MRPL28 -0.42 -7.45 -0.38 8.17e-13 Bone mineral density (spine);Bone mineral density; LUSC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.93 16.48 0.67 4.67e-45 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 8.92 0.44 3.22e-17 Monocyte percentage of white cells; LUSC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg12311346 chr5:56204834 C5orf35 -0.67 -10.1 -0.48 4.07e-21 Coronary artery disease; LUSC cis rs7208859 0.623 rs56095789 chr17:29060170 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg14440974 chr22:39074834 NA -0.36 -6.1 -0.32 2.87e-9 Menopause (age at onset); LUSC cis rs478304 0.903 rs12293022 chr11:65531698 C/T cg08755490 chr11:65554678 OVOL1 0.41 5.87 0.31 1.05e-8 Acne (severe); LUSC cis rs3764563 1.000 rs2031062 chr19:15717573 T/C cg20725493 chr19:15740067 CYP4F8 -0.67 -6.58 -0.34 1.85e-10 Inflammatory biomarkers; LUSC cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg03213289 chr20:61660250 NA 0.67 13.95 0.61 3.76e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg18876405 chr7:65276391 NA -0.58 -9.44 -0.46 6.45e-19 Aortic root size; LUSC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -6.94 -0.35 2.11e-11 Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC cis rs921665 0.748 rs1869421 chr2:3202068 G/T cg02624386 chr2:3182749 NA 0.62 6.61 0.34 1.55e-10 World class endurance athleticism; LUSC trans rs7170930 0.618 rs55865344 chr15:66541771 T/C cg06396762 chr16:3202609 NA -0.72 -5.98 -0.31 5.75e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1595825 0.891 rs58111212 chr2:198889896 T/C cg00982548 chr2:198649783 BOLL -0.54 -6.93 -0.35 2.2e-11 Ulcerative colitis; LUSC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg27165867 chr14:105738592 BRF1 -0.56 -8.48 -0.42 7.47e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg08109568 chr15:31115862 NA 0.74 11.08 0.52 1.63e-24 Huntington's disease progression; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12766407 chr15:56657635 TEX9 -0.42 -6.05 -0.31 3.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.34 0.33 7.5e-10 Tonsillectomy; LUSC cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg06784218 chr1:46089804 CCDC17 0.37 6.26 0.32 1.15e-9 Platelet count; LUSC trans rs9747201 1.000 rs12943668 chr17:80109930 C/T cg07393940 chr7:158741817 NA -0.51 -8.09 -0.4 1.12e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10754283 0.967 rs6698273 chr1:90106791 T/A cg21401794 chr1:90099060 LRRC8C 0.65 9.69 0.47 9.88e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs17270561 0.609 rs6924794 chr6:25735874 A/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs4076764 0.801 rs6675964 chr1:163375960 A/G cg06092702 chr1:163392909 NA -0.39 -6.55 -0.34 2.21e-10 Motion sickness; LUSC cis rs12220238 1.000 rs11000887 chr10:75897542 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.11 0.36 7.3e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.51 0.34 2.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3750965 0.959 rs4930264 chr11:68852181 C/T cg06818126 chr11:68850279 TPCN2 -0.45 -6.53 -0.34 2.4e-10 Hair color; LUSC cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg08999081 chr20:33150536 PIGU -0.41 -7.56 -0.38 3.88e-13 Glomerular filtration rate (creatinine); LUSC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11644478 chr21:40555479 PSMG1 -0.82 -14.64 -0.63 7.79e-38 Cognitive function; LUSC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg11861562 chr11:117069780 TAGLN 0.44 7.86 0.4 5.19e-14 Blood protein levels; LUSC cis rs7584330 0.554 rs6739456 chr2:238385092 G/C cg14458575 chr2:238380390 NA 0.66 8.32 0.41 2.25e-15 Prostate cancer; LUSC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg23719950 chr11:63933701 MACROD1 -0.62 -8.07 -0.4 1.26e-14 Mean platelet volume; LUSC cis rs10751667 0.600 rs10902264 chr11:1003523 G/A cg06064525 chr11:970664 AP2A2 -0.3 -5.92 -0.31 7.81e-9 Alzheimer's disease (late onset); LUSC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg18681998 chr4:17616180 MED28 0.86 15.91 0.66 8.29e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7527798 0.592 rs12144801 chr1:207857773 A/G cg09232269 chr1:207846808 CR1L -0.31 -6.71 -0.34 8.55e-11 Erythrocyte sedimentation rate; LUSC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg24675658 chr1:53192096 ZYG11B 0.72 12.06 0.55 4.64e-28 Monocyte count; LUSC cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg24642439 chr20:33292090 TP53INP2 -0.53 -8.09 -0.4 1.11e-14 Glomerular filtration rate (creatinine); LUSC cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg18681998 chr4:17616180 MED28 0.86 16.03 0.66 2.84e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4919087 0.962 rs10786324 chr10:99054387 A/G cg25902810 chr10:99078978 FRAT1 0.47 6.66 0.34 1.14e-10 Monocyte count; LUSC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg11764359 chr7:65958608 NA -0.69 -11.11 -0.52 1.26e-24 Aortic root size; LUSC trans rs11098499 0.955 rs7684942 chr4:120162201 C/T cg25214090 chr10:38739885 LOC399744 0.46 6.71 0.34 8.23e-11 Corneal astigmatism; LUSC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg02574844 chr11:5959923 NA -0.45 -6.36 -0.33 6.66e-10 DNA methylation (variation); LUSC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg16434002 chr17:42200994 HDAC5 -0.44 -6.0 -0.31 5.26e-9 Total body bone mineral density; LUSC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg04727924 chr7:799746 HEATR2 -0.53 -6.37 -0.33 6.27e-10 Cerebrospinal P-tau181p levels; LUSC cis rs806215 1.000 rs806219 chr7:127240094 A/C cg25922125 chr7:127225783 GCC1 0.58 7.38 0.37 1.26e-12 Type 2 diabetes; LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg15383120 chr6:291909 DUSP22 -0.47 -7.36 -0.37 1.44e-12 Menopause (age at onset); LUSC cis rs17155006 0.691 rs409815 chr7:107745443 A/G cg05962710 chr7:107745446 LAMB4 0.35 6.18 0.32 1.87e-9 Pneumococcal bacteremia; LUSC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs11264213 0.901 rs72661616 chr1:36370512 G/A cg27506609 chr1:36549197 TEKT2 0.68 7.88 0.4 4.58e-14 Schizophrenia; LUSC cis rs4730250 0.707 rs257377 chr7:106801088 G/T cg02696742 chr7:106810147 HBP1 -0.64 -8.94 -0.44 2.63e-17 Osteoarthritis; LUSC cis rs11971779 0.616 rs6965143 chr7:139026608 C/G cg23387468 chr7:139079360 LUC7L2 0.4 6.01 0.31 4.77e-9 Diisocyanate-induced asthma; LUSC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg12927641 chr6:109611667 NA -0.36 -6.12 -0.32 2.66e-9 Reticulocyte fraction of red cells; LUSC cis rs67311347 0.713 rs4974018 chr3:40307419 G/A cg17264618 chr3:40429014 ENTPD3 0.29 6.39 0.33 5.56e-10 Renal cell carcinoma; LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.94 0.31 7.13e-9 Renal function-related traits (BUN); LUSC cis rs10779751 0.649 rs1318348 chr1:11130418 A/G cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC cis rs2976388 0.967 rs2976397 chr8:143764613 G/T cg17252645 chr8:143867129 LY6D -0.38 -6.48 -0.33 3.3e-10 Urinary tract infection frequency; LUSC cis rs7267979 0.932 rs13040655 chr20:25582197 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.56 0.69 2.29e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6977660 0.943 rs6959678 chr7:19821759 C/A cg05791153 chr7:19748676 TWISTNB 0.53 5.83 0.3 1.29e-8 Thyroid stimulating hormone; LUSC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg04267008 chr7:1944627 MAD1L1 -0.65 -9.99 -0.48 9.85e-21 Bipolar disorder and schizophrenia; LUSC trans rs35110281 0.744 rs230645 chr21:44918607 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.57 -9.37 -0.46 1.15e-18 Mean corpuscular volume; LUSC cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.82 -0.51 1.39e-23 Monocyte percentage of white cells; LUSC cis rs6845621 0.745 rs1400939 chr4:18856479 C/T cg12196642 chr4:18937545 NA -0.31 -5.78 -0.3 1.72e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg11494091 chr17:61959527 GH2 0.65 13.69 0.6 3.62e-34 Prudent dietary pattern; LUSC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.73 0.39 1.26e-13 Parkinson's disease; LUSC cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg25173405 chr17:45401733 C17orf57 0.36 5.72 0.3 2.36e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2262909 0.962 rs12610034 chr19:22314528 G/A cg05197062 chr11:11642011 GALNTL4 0.54 7.62 0.38 2.7e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7267979 0.966 rs2500433 chr20:25296335 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.73 -0.7 4.71e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg05768032 chr16:30646687 NA 0.41 6.17 0.32 2.03e-9 Multiple myeloma; LUSC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.49 0.46 4.39e-19 Bipolar disorder; LUSC cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.12 0.36 6.53e-12 Colorectal cancer; LUSC cis rs540254 0.578 rs4656933 chr1:160782561 T/A cg20255094 chr1:160771763 LY9 0.56 6.69 0.34 9.55e-11 Blood protein levels; LUSC cis rs8060686 0.641 rs7199588 chr16:68224582 C/T cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs7613875 0.663 rs6762477 chr3:50093209 G/A cg21659725 chr3:3221576 CRBN -0.53 -8.46 -0.42 8.33e-16 Body mass index; LUSC cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -9.55 -0.46 2.9e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7178572 0.889 rs7170877 chr15:77832019 C/G cg22256960 chr15:77711686 NA -0.5 -8.27 -0.41 3.13e-15 Type 2 diabetes; LUSC trans rs35851103 0.600 rs4841662 chr8:11843758 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.86 -0.44 4.97e-17 Neuroticism; LUSC cis rs1595825 0.891 rs7583917 chr2:198576950 A/G cg00982548 chr2:198649783 BOLL -0.53 -6.69 -0.34 9.32e-11 Ulcerative colitis; LUSC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg26380479 chr7:97908229 NA -0.28 -6.08 -0.32 3.21e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1387259 0.690 rs1601985 chr12:48761914 A/G cg04545296 chr12:48745243 ZNF641 0.3 5.75 0.3 2.02e-8 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs3750082 0.582 rs6462436 chr7:32970900 T/C cg08946731 chr7:32981826 RP9P 0.41 6.5 0.34 2.95e-10 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg17366294 chr4:99064904 C4orf37 0.54 9.6 0.47 1.91e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs4499344 0.576 rs259280 chr19:33161452 C/T cg22980127 chr19:33182716 NUDT19 -0.45 -6.66 -0.34 1.1e-10 Mean platelet volume; LUSC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg22800045 chr5:56110881 MAP3K1 -0.53 -7.31 -0.37 2.03e-12 Type 2 diabetes; LUSC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg20203395 chr5:56204925 C5orf35 -0.7 -9.33 -0.45 1.56e-18 Initial pursuit acceleration; LUSC cis rs16976116 0.901 rs28864456 chr15:55503092 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.16 0.32 2.05e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs7267979 1.000 rs2482940 chr20:25349830 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.87 -0.7 1.34e-50 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03591801 chr19:36119784 RBM42 -0.42 -6.11 -0.32 2.74e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10147044 chr15:75230572 COX5A -0.48 -6.6 -0.34 1.61e-10 Hepatitis; LUSC cis rs76662990 0.764 rs76733847 chr5:73888150 G/A cg01264639 chr5:73839484 NA 0.54 5.71 0.3 2.43e-8 Residual cognition; LUSC cis rs1670533 0.818 rs585735 chr4:1080391 G/C cg02018176 chr4:1364513 KIAA1530 0.46 6.5 0.33 3e-10 Recombination rate (females); LUSC trans rs6951245 0.706 rs1133116 chr7:1195215 A/C cg13565492 chr6:43139072 SRF -0.57 -6.23 -0.32 1.4e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg13834567 chr19:42817981 TMEM145 -0.52 -6.79 -0.35 5.28e-11 Bipolar disorder and schizophrenia; LUSC cis rs11626933 1.000 rs11626933 chr14:90754311 A/G cg14092571 chr14:90743983 NA -0.88 -18.24 -0.71 4.54e-52 Gut microbiota (bacterial taxa); LUSC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg00383909 chr3:49044727 WDR6 0.42 5.64 0.3 3.58e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs3806843 0.966 rs2563262 chr5:140137712 C/G cg19875535 chr5:140030758 IK -0.47 -7.7 -0.39 1.55e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg21724239 chr8:58056113 NA 0.85 9.05 0.44 1.18e-17 Developmental language disorder (linguistic errors); LUSC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; LUSC trans rs6598955 0.671 rs12142535 chr1:26589698 T/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg00343986 chr7:65444356 GUSB -0.48 -7.29 -0.37 2.19e-12 Aortic root size; LUSC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg22800045 chr5:56110881 MAP3K1 0.75 9.77 0.47 5.46e-20 Initial pursuit acceleration; LUSC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg11244672 chr19:19639970 YJEFN3 -0.6 -7.33 -0.37 1.69e-12 Bipolar disorder; LUSC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg24562669 chr7:97807699 LMTK2 0.35 6.12 0.32 2.58e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg16339924 chr4:17578868 LAP3 -0.49 -7.55 -0.38 4.21e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2425143 1.000 rs73905926 chr20:34251982 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -6.57 -0.34 1.88e-10 Blood protein levels; LUSC cis rs12908161 0.959 rs17534709 chr15:85314397 G/C cg12863693 chr15:85201151 NMB 0.41 8.27 0.41 3.15e-15 Schizophrenia; LUSC cis rs1568889 0.938 rs12795971 chr11:28355104 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 8.74 0.43 1.17e-16 Bipolar disorder; LUSC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg04539111 chr16:67997858 SLC12A4 -0.46 -6.26 -0.32 1.17e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.98 0.72 5.41e-55 Chronic sinus infection; LUSC trans rs9329221 0.619 rs591346 chr8:9818065 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.57 -0.34 1.94e-10 Neuroticism; LUSC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg13770153 chr20:60521292 NA -0.46 -6.61 -0.34 1.57e-10 Body mass index; LUSC cis rs1113500 0.933 rs10881497 chr1:108634515 A/G cg06207961 chr1:108661230 NA -0.4 -7.44 -0.38 8.48e-13 Growth-regulated protein alpha levels; LUSC cis rs16910800 1.000 rs2468655 chr11:23197060 G/A cg20040320 chr11:23191996 NA 0.44 6.55 0.34 2.15e-10 Cancer; LUSC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg08280861 chr8:58055591 NA 0.57 8.32 0.41 2.28e-15 Developmental language disorder (linguistic errors); LUSC cis rs12310956 0.532 rs10844720 chr12:33987859 G/T cg06521331 chr12:34319734 NA -0.47 -7.55 -0.38 4.09e-13 Morning vs. evening chronotype; LUSC cis rs9549260 0.755 rs7990923 chr13:41215972 A/G cg21288729 chr13:41239152 FOXO1 0.64 9.9 0.48 2.01e-20 Red blood cell count; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg16886045 chr19:1269073 CIRBP;C19orf23 0.7 6.14 0.32 2.31e-9 Body mass index; LUSC cis rs9300255 0.544 rs1790130 chr12:123701270 A/C cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs3106136 0.546 rs2632417 chr4:95137542 G/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.46 -0.42 8.25e-16 Capecitabine sensitivity; LUSC cis rs6961069 0.708 rs7807445 chr7:80217974 A/G cg04458919 chr7:80252533 CD36 -0.4 -7.12 -0.36 6.65e-12 Platelet count; LUSC trans rs7824557 0.707 rs3808518 chr8:11143272 A/C cg06636001 chr8:8085503 FLJ10661 -0.54 -8.35 -0.42 1.84e-15 Retinal vascular caliber; LUSC cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg13010199 chr12:38710504 ALG10B 0.69 10.65 0.5 5.27e-23 Bladder cancer; LUSC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs13401104 0.796 rs12472312 chr2:237113030 G/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.35e-8 Educational attainment; LUSC cis rs6500395 1.000 rs1872654 chr16:48671050 C/T cg04672837 chr16:48644449 N4BP1 0.46 6.91 0.35 2.41e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg21862992 chr11:68658383 NA 0.48 7.71 0.39 1.45e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1801251 0.711 rs778368 chr2:233745333 G/C cg08000102 chr2:233561755 GIGYF2 -0.47 -6.96 -0.36 1.79e-11 Coronary artery disease; LUSC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.85 -0.3 1.2e-8 Total body bone mineral density; LUSC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg23262073 chr20:60523788 NA 0.38 6.0 0.31 5.14e-9 Body mass index; LUSC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.95 18.97 0.72 5.61e-55 Prudent dietary pattern; LUSC cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg12011299 chr4:100065546 ADH4 -0.71 -10.9 -0.51 7.13e-24 Alcohol dependence; LUSC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -10.17 -0.49 2.42e-21 Developmental language disorder (linguistic errors); LUSC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg20821713 chr7:1055600 C7orf50 -0.49 -6.4 -0.33 5.12e-10 Bronchopulmonary dysplasia; LUSC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg00750074 chr16:89608354 SPG7 -0.46 -7.84 -0.39 6.19e-14 Multiple myeloma (IgH translocation); LUSC cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.37 0.42 1.64e-15 Colorectal cancer; LUSC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg25039879 chr17:56429692 SUPT4H1 0.72 9.69 0.47 1e-19 Cognitive test performance; LUSC cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg03015672 chr10:32216066 ARHGAP12 0.33 5.94 0.31 7.06e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9467711 0.606 rs34104395 chr6:26478252 C/T cg09904177 chr6:26538194 HMGN4 -0.78 -6.2 -0.32 1.68e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg04455712 chr21:45112962 RRP1B 0.46 8.78 0.43 8.8e-17 Mean corpuscular volume; LUSC cis rs2387326 0.672 rs12254264 chr10:129945519 C/T cg16087940 chr10:129947807 NA -0.4 -6.12 -0.32 2.59e-9 Select biomarker traits; LUSC trans rs11039798 0.858 rs11039730 chr11:48440495 A/G cg15704280 chr7:45808275 SEPT13 0.72 6.05 0.31 3.95e-9 Axial length; LUSC trans rs853679 0.556 rs34588114 chr6:28080628 C/A cg06606381 chr12:133084897 FBRSL1 -1.01 -9.06 -0.44 1.14e-17 Depression; LUSC cis rs10193935 0.901 rs13384404 chr2:42601147 G/T cg27598129 chr2:42591480 NA -0.65 -8.74 -0.43 1.19e-16 Colonoscopy-negative controls vs population controls; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg07605469 chr12:113573757 RASAL1 0.39 6.01 0.31 4.95e-9 Schizophrenia; LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg05973401 chr12:123451056 ABCB9 0.62 8.84 0.44 5.58e-17 Platelet count; LUSC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg06219351 chr7:158114137 PTPRN2 -0.54 -8.36 -0.42 1.71e-15 Response to amphetamines; LUSC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg00334542 chr7:100209784 MOSPD3 -0.48 -5.68 -0.3 2.87e-8 Other erythrocyte phenotypes; LUSC cis rs8014204 0.806 rs11159105 chr14:75298052 C/T cg06637938 chr14:75390232 RPS6KL1 0.65 11.0 0.52 3.23e-24 Caffeine consumption; LUSC cis rs6582630 0.599 rs8189525 chr12:38424982 A/C cg26384229 chr12:38710491 ALG10B 0.52 7.79 0.39 8.58e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.59 8.45 0.42 9.09e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg12432903 chr7:1882776 MAD1L1 -0.4 -6.67 -0.34 1.08e-10 Bipolar disorder and schizophrenia; LUSC trans rs11992162 0.591 rs34123222 chr8:11795349 C/T cg27411982 chr8:10470053 RP1L1 -0.44 -6.57 -0.34 1.96e-10 Monocyte count; LUSC cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg03015672 chr10:32216066 ARHGAP12 0.34 6.06 0.31 3.73e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg24675658 chr1:53192096 ZYG11B -0.71 -12.14 -0.55 2.41e-28 Monocyte count; LUSC cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs5769765 0.908 rs7410601 chr22:50317187 C/T cg02269571 chr22:50332266 NA -0.62 -9.15 -0.45 5.66e-18 Schizophrenia; LUSC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg04450456 chr4:17643702 FAM184B 0.39 6.6 0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7923609 0.756 rs6479908 chr10:65333648 C/G cg01631684 chr10:65280961 REEP3 0.38 5.75 0.3 2.04e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg21782813 chr7:2030301 MAD1L1 -0.47 -8.04 -0.4 1.61e-14 Bipolar disorder and schizophrenia; LUSC cis rs9399135 0.967 rs2297338 chr6:135375762 G/A cg22676075 chr6:135203613 NA 0.46 7.21 0.37 3.84e-12 Red blood cell count; LUSC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg12311346 chr5:56204834 C5orf35 -0.84 -9.44 -0.46 6.7e-19 Type 2 diabetes; LUSC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg13877915 chr19:58951672 ZNF132 0.48 7.55 0.38 4.16e-13 Uric acid clearance; LUSC trans rs9291683 0.655 rs3822242 chr4:10094904 T/C cg26043149 chr18:55253948 FECH -0.54 -8.17 -0.41 6.46e-15 Bone mineral density; LUSC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg06263672 chr7:65235340 NA 0.42 6.08 0.32 3.37e-9 Calcium levels; LUSC cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg08807101 chr21:30365312 RNF160 -0.76 -13.43 -0.59 3.45e-33 Dental caries; LUSC cis rs9392556 0.829 rs693953 chr6:4120565 A/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.16 -0.32 2.06e-9 Blood metabolite levels; LUSC cis rs4700695 0.668 rs253214 chr5:65499401 A/G cg21114390 chr5:65439923 SFRS12 -0.47 -6.86 -0.35 3.31e-11 Facial morphology (factor 19); LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg02018176 chr4:1364513 KIAA1530 -0.67 -11.97 -0.55 1.01e-27 Obesity-related traits; LUSC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg17252645 chr8:143867129 LY6D 0.38 6.72 0.34 8.03e-11 Urinary tract infection frequency; LUSC cis rs113835537 0.529 rs17065 chr11:66277035 G/A cg24851651 chr11:66362959 CCS 0.52 7.58 0.38 3.34e-13 Airway imaging phenotypes; LUSC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg06238570 chr21:40685208 BRWD1 -0.63 -10.46 -0.5 2.5e-22 Cognitive function; LUSC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg23985595 chr17:80112537 CCDC57 -0.31 -5.86 -0.31 1.12e-8 Life satisfaction; LUSC cis rs12220238 1.000 rs11000909 chr10:75944828 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 6.89 0.35 2.71e-11 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs6598955 0.671 rs11247914 chr1:26648838 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.42 -0.42 1.16e-15 Obesity-related traits; LUSC cis rs9309711 0.961 rs11678655 chr2:3476234 T/G cg10845886 chr2:3471009 TTC15 -0.63 -8.24 -0.41 4.09e-15 Neurofibrillary tangles; LUSC cis rs1577917 1.000 rs34106666 chr6:86676258 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -8.13 -0.41 8.66e-15 Response to antipsychotic treatment; LUSC trans rs2797160 1.000 rs1739380 chr6:126012858 T/C cg05039488 chr6:79577232 IRAK1BP1 0.44 6.58 0.34 1.85e-10 Endometrial cancer; LUSC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg07414643 chr4:187882934 NA 0.55 10.33 0.49 7e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769707 0.681 rs9616329 chr22:50026314 G/A cg20744362 chr22:50050164 C22orf34 0.38 7.45 0.38 7.96e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.18 0.58 3.23e-32 Alzheimer's disease; LUSC cis rs4253772 0.591 rs11703848 chr22:46685131 A/G cg18190219 chr22:46762943 CELSR1 -0.55 -6.28 -0.33 1.05e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs12477438 0.520 rs12467504 chr2:99543208 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.48 -5.84 -0.3 1.24e-8 Chronic sinus infection; LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg07507251 chr3:52567010 NT5DC2 0.36 6.99 0.36 1.49e-11 Bipolar disorder; LUSC cis rs3820928 0.874 rs55743026 chr2:227802813 G/A cg11843606 chr2:227700838 RHBDD1 -0.53 -7.75 -0.39 1.14e-13 Pulmonary function; LUSC cis rs55675132 0.664 rs1575071 chr1:115567833 G/A cg01522456 chr1:115632236 TSPAN2 -0.46 -5.74 -0.3 2.12e-8 Schizophrenia; LUSC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg16680214 chr1:154839983 KCNN3 -0.56 -10.99 -0.52 3.44e-24 Prostate cancer; LUSC cis rs6542838 0.641 rs12467189 chr2:99495820 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.08 -0.32 3.32e-9 Fear of minor pain; LUSC cis rs4148883 0.675 rs11724783 chr4:100099688 C/A cg12011299 chr4:100065546 ADH4 0.47 7.67 0.39 1.9e-13 Alcohol dependence; LUSC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg19077165 chr18:44547161 KATNAL2 -0.41 -6.16 -0.32 2.04e-9 Personality dimensions; LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg03354898 chr7:1950403 MAD1L1 0.35 6.81 0.35 4.59e-11 Bipolar disorder and schizophrenia; LUSC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg06582575 chr6:163149167 PACRG;PARK2 1.11 14.54 0.62 1.83e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg00509249 chr6:109615579 CCDC162 -0.34 -6.12 -0.32 2.6e-9 Reticulocyte fraction of red cells; LUSC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg11645453 chr3:52864694 ITIH4 -0.37 -8.66 -0.43 2.02e-16 Bipolar disorder; LUSC cis rs1348850 0.567 rs12994392 chr2:178536640 A/G cg22681709 chr2:178499509 PDE11A -0.55 -11.03 -0.52 2.5300000000000002e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05255149 chr17:80675120 FN3KRP 0.43 6.25 0.32 1.24e-9 Asthma; LUSC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg08798685 chr6:27730294 NA -0.6 -5.89 -0.31 9.28e-9 Depression; LUSC cis rs9354352 0.791 rs4710306 chr6:66700271 A/G cg07460842 chr6:66804631 NA -0.59 -8.32 -0.41 2.21e-15 Initial pursuit acceleration in psychotic disorders; LUSC trans rs459571 0.959 rs456205 chr9:136911146 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.74 -12.41 -0.56 2.35e-29 Platelet distribution width; LUSC cis rs765787 0.530 rs4238377 chr15:45541981 A/G cg25801113 chr15:45476975 SHF 0.34 7.04 0.36 1.13e-11 Uric acid levels; LUSC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.69 0.3 2.71e-8 Life satisfaction; LUSC cis rs7267979 1.000 rs1888999 chr20:25291848 C/T cg03522245 chr20:25566470 NINL 0.36 5.81 0.3 1.46e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg05855489 chr10:104503620 C10orf26 0.62 7.84 0.39 5.91e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs748404 0.697 rs504417 chr15:43554226 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 8.35 0.42 1.82e-15 Lung cancer; LUSC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg04511125 chr2:88470314 THNSL2 -0.43 -6.54 -0.34 2.37e-10 Response to metformin (IC50); LUSC cis rs500891 0.693 rs1144196 chr6:83977714 C/A cg08257003 chr6:84140564 ME1 0.33 7.41 0.38 1.07e-12 Platelet-derived growth factor BB levels; LUSC cis rs9527 0.590 rs1807298 chr10:104870218 G/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.67 0.39 1.86e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.954 rs13133522 chr4:120324424 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs7615952 0.799 rs13315434 chr3:125641394 T/G cg05084668 chr3:125655381 ALG1L -0.77 -11.86 -0.54 2.63e-27 Blood pressure (smoking interaction); LUSC trans rs6600671 0.967 rs12069545 chr1:121172203 A/G cg00646200 chr1:148855367 NA 0.45 7.18 0.37 4.44e-12 Hip geometry; LUSC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg03709012 chr19:19516395 GATAD2A 0.74 11.3 0.53 2.7e-25 Tonsillectomy; LUSC cis rs2797160 1.000 rs1832938 chr6:125988964 G/C cg05901451 chr6:126070800 HEY2 -0.57 -8.79 -0.43 7.91e-17 Endometrial cancer; LUSC cis rs9395066 0.545 rs4711807 chr6:44911652 G/A cg25276700 chr6:44698697 NA 0.3 6.04 0.31 4.11e-9 Height; LUSC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs4771122 0.740 rs1006353 chr13:28047269 A/G cg22138327 chr13:27999177 GTF3A -0.67 -10.45 -0.5 2.67e-22 Body mass index; LUSC cis rs9486719 0.857 rs11751075 chr6:97065751 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -11.28 -0.53 3.32e-25 Migraine;Coronary artery disease; LUSC cis rs9467773 1.000 rs1884949 chr6:26568067 G/A cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC trans rs877282 0.898 rs11253348 chr10:765852 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.44 -0.33 4.05e-10 Uric acid levels; LUSC cis rs9359856 0.529 rs1328017 chr6:90297603 T/C cg13799429 chr6:90582589 CASP8AP2 0.77 7.43 0.38 9.35e-13 Bipolar disorder; LUSC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg21782813 chr7:2030301 MAD1L1 0.52 8.61 0.43 2.99e-16 Bipolar disorder and schizophrenia; LUSC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg01616529 chr11:638424 DRD4 -0.35 -5.8 -0.3 1.5e-8 Systemic lupus erythematosus; LUSC cis rs185694 1.000 rs613291 chr13:30894404 T/C cg07600127 chr13:30881527 KATNAL1 -0.54 -5.9 -0.31 8.77e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; LUSC cis rs9547692 1.000 rs493248 chr13:37473386 C/T cg01034396 chr13:37494802 SMAD9 0.3 5.74 0.3 2.13e-8 Coronary artery disease; LUSC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg21361702 chr7:150065534 REPIN1 0.52 6.76 0.35 6.24e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 22.01 0.77 5.62e-67 Prudent dietary pattern; LUSC cis rs4555082 0.834 rs28489970 chr14:105748862 T/C cg13114125 chr14:105738426 BRF1 -0.91 -14.92 -0.63 6.02e-39 Mean platelet volume;Platelet distribution width; LUSC cis rs17270561 0.636 rs4360128 chr6:25734558 A/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg18876405 chr7:65276391 NA -0.55 -8.66 -0.43 2.09e-16 Aortic root size; LUSC cis rs317689 0.690 rs317630 chr12:69637847 T/C cg11871910 chr12:69753446 YEATS4 0.45 5.79 0.3 1.64e-8 Response to diuretic therapy; LUSC trans rs72674100 1.000 rs28496290 chr4:97969761 G/T cg16405019 chr1:18959625 PAX7 -0.59 -6.38 -0.33 5.78e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs73198271 0.562 rs2048420 chr8:8667603 G/A cg01851573 chr8:8652454 MFHAS1 0.65 8.46 0.42 8.7e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg06238570 chr21:40685208 BRWD1 0.52 7.96 0.4 2.73e-14 Cognitive function; LUSC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg24562669 chr7:97807699 LMTK2 0.35 6.08 0.32 3.26e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9486715 0.867 rs9486444 chr6:96963619 A/G cg06623918 chr6:96969491 KIAA0776 0.93 17.12 0.68 1.26e-47 Headache; LUSC cis rs10492096 0.947 rs11559082 chr12:6602367 C/T cg13857086 chr12:6580257 VAMP1 0.61 7.25 0.37 2.89e-12 Hip geometry; LUSC trans rs61931739 0.649 rs708144 chr12:33731158 T/C cg26384229 chr12:38710491 ALG10B 0.42 6.07 0.32 3.55e-9 Morning vs. evening chronotype; LUSC cis rs116095464 1.000 rs56095714 chr5:311256 C/T cg22857025 chr5:266934 NA -1.13 -8.37 -0.42 1.62e-15 Breast cancer; LUSC cis rs11098499 0.754 rs7672594 chr4:120248543 A/C cg24375607 chr4:120327624 NA 0.76 12.21 0.56 1.33e-28 Corneal astigmatism; LUSC cis rs2295359 0.892 rs4655686 chr1:67638004 T/A cg12940439 chr1:67600707 NA 0.37 6.04 0.31 4.13e-9 Psoriasis; LUSC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg13206674 chr6:150067644 NUP43 0.62 9.87 0.48 2.41e-20 Lung cancer; LUSC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg13206674 chr6:150067644 NUP43 0.57 9.09 0.45 9.1e-18 Lung cancer; LUSC cis rs3862030 0.839 rs7078511 chr10:104283874 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -9.75 -0.47 6.19e-20 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs782590 0.934 rs62165184 chr2:55788253 G/C cg18811423 chr2:55921094 PNPT1 0.83 14.33 0.62 1.2e-36 Metabolic syndrome; LUSC cis rs2932538 0.922 rs12125361 chr1:113144779 C/T cg22162597 chr1:113214053 CAPZA1 0.7 10.01 0.48 8.67e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs892961 0.932 rs67415822 chr17:75412678 A/G cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg01475377 chr6:109611718 NA -0.41 -7.26 -0.37 2.7e-12 Reticulocyte fraction of red cells; LUSC cis rs77741769 0.571 rs989987 chr12:121274062 C/T cg02419362 chr12:121203948 SPPL3 0.46 8.57 0.42 3.78e-16 Mean corpuscular volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20617676 chr7:123389167 WASL -0.47 -6.38 -0.33 5.9e-10 Bipolar disorder and schizophrenia; LUSC cis rs4499344 0.526 rs17832981 chr19:33034461 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.72 9.96 0.48 1.21e-20 Mean platelet volume; LUSC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg22903471 chr2:27725779 GCKR -0.41 -6.89 -0.35 2.71e-11 Total body bone mineral density; LUSC cis rs4629180 0.586 rs1509494 chr2:102134862 G/T cg04415270 chr2:102091202 RFX8 -0.45 -7.78 -0.39 8.93e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs2274273 0.837 rs6573017 chr14:55802243 G/A cg04306507 chr14:55594613 LGALS3 0.56 12.81 0.57 8.09e-31 Protein biomarker; LUSC cis rs921968 0.613 rs2303566 chr2:219557738 C/T cg02176678 chr2:219576539 TTLL4 -0.61 -11.13 -0.52 1.14e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg25258033 chr6:167368657 RNASET2 0.47 7.42 0.38 9.92e-13 Crohn's disease; LUSC cis rs734999 0.549 rs2764840 chr1:2529437 C/T cg18932078 chr1:2524107 MMEL1 -0.29 -6.44 -0.33 4.15e-10 Ulcerative colitis; LUSC cis rs10875746 0.903 rs12301339 chr12:48475233 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03576123 chr11:487126 PTDSS2 -1.02 -10.84 -0.51 1.14e-23 Body mass index; LUSC cis rs4925386 0.681 rs2427294 chr20:60927257 G/A cg06026331 chr20:60912101 LAMA5 0.62 7.34 0.37 1.64e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs28647808 0.881 rs71483207 chr9:136258698 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg22907277 chr7:1156413 C7orf50 0.46 7.34 0.37 1.69e-12 Longevity;Endometriosis; LUSC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.92 -0.31 8.02e-9 Intelligence (multi-trait analysis); LUSC trans rs34421088 0.560 rs2248315 chr8:11397086 T/A cg08975724 chr8:8085496 FLJ10661 -0.5 -7.51 -0.38 5.36e-13 Neuroticism; LUSC cis rs7267979 0.966 rs6050532 chr20:25308793 A/T cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.71e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg05347473 chr6:146136440 FBXO30 -0.65 -11.14 -0.52 1.05e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs11252926 0.931 rs4881399 chr10:567325 A/G cg16346588 chr10:242978 ZMYND11 0.46 6.48 0.33 3.27e-10 Psychosis in Alzheimer's disease; LUSC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg05802129 chr4:122689817 NA -0.45 -7.58 -0.38 3.37e-13 Type 2 diabetes; LUSC cis rs7615316 1.000 rs6440099 chr3:142356226 C/T cg16271453 chr3:142027066 XRN1 -0.34 -5.74 -0.3 2.09e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs909002 0.925 rs10798882 chr1:32108547 C/G cg01639898 chr1:32083012 HCRTR1 -0.25 -5.81 -0.3 1.47e-8 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20227886 chr18:48405353 ME2 -0.48 -6.3 -0.33 9.49e-10 Bipolar disorder and schizophrenia; LUSC cis rs3126085 0.935 rs4845734 chr1:152167473 T/C cg26876637 chr1:152193138 HRNR 0.45 6.36 0.33 6.5e-10 Atopic dermatitis; LUSC cis rs8141797 0.792 rs3752497 chr22:24581207 C/T cg00411358 chr22:24577142 SUSD2 -0.56 -6.0 -0.31 5.03e-9 Amyotrophic lateral sclerosis;Coronary artery disease; LUSC cis rs7098414 0.511 rs10749592 chr10:82150891 C/T cg00277334 chr10:82204260 NA -0.54 -8.75 -0.43 1.05e-16 Post bronchodilator FEV1; LUSC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg13393036 chr8:95962371 TP53INP1 -0.5 -10.92 -0.51 6.08e-24 Type 2 diabetes; LUSC cis rs911119 1.000 rs2016161 chr20:23621174 G/T cg16589663 chr20:23618590 CST3 -0.52 -6.3 -0.33 9.18e-10 Chronic kidney disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05351267 chr16:1877388 HAGH;FAHD1 -0.43 -6.42 -0.33 4.58e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg26587870 chr6:27730563 NA -0.65 -6.04 -0.31 4.2e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs10197940 0.578 rs2432946 chr2:152306897 G/T cg19508488 chr2:152266495 RIF1 -0.39 -5.76 -0.3 1.95e-8 Lung cancer; LUSC cis rs2637266 0.783 rs7898786 chr10:78481338 T/C cg18941641 chr10:78392320 NA 0.36 6.49 0.33 3.06e-10 Pulmonary function; LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg14004847 chr7:1930337 MAD1L1 -0.54 -8.15 -0.41 7.48e-15 Bipolar disorder and schizophrenia; LUSC cis rs12681287 0.752 rs2917557 chr8:87314071 C/T cg27223183 chr8:87520930 FAM82B -0.47 -5.78 -0.3 1.75e-8 Caudate activity during reward; LUSC cis rs9646944 0.501 rs10176820 chr2:103054420 T/C cg20060108 chr2:102954350 IL1RL1 0.46 6.39 0.33 5.51e-10 Blood protein levels; LUSC cis rs9611519 0.964 rs20551 chr22:41548008 A/G cg13813247 chr22:41461852 NA -0.39 -7.03 -0.36 1.17e-11 Neuroticism; LUSC trans rs6600671 1.000 rs11249351 chr1:121171942 G/A cg00646200 chr1:148855367 NA 0.45 7.18 0.37 4.44e-12 Hip geometry; LUSC cis rs516243 0.703 rs169538 chr1:10737045 T/C cg02903756 chr1:10750680 CASZ1 -0.47 -8.47 -0.42 7.96e-16 Migraine - clinic-based; LUSC cis rs899997 1.000 rs12899940 chr15:79001699 A/G cg04896959 chr15:78267971 NA -0.49 -10.27 -0.49 1.14e-21 Coronary artery disease or large artery stroke; LUSC cis rs11122272 0.735 rs2437149 chr1:231490105 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.75 -0.47 6.45e-20 Hemoglobin concentration; LUSC cis rs7618501 1.000 rs6446295 chr3:49809063 G/T cg12257692 chr3:49977190 RBM6 0.2 5.65 0.3 3.36e-8 Intelligence (multi-trait analysis); LUSC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg24209194 chr3:40518798 ZNF619 -0.41 -5.85 -0.3 1.19e-8 Renal cell carcinoma; LUSC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg23985595 chr17:80112537 CCDC57 0.31 5.88 0.31 9.8e-9 Life satisfaction; LUSC cis rs870825 0.860 rs61165411 chr4:185604461 G/A cg04058563 chr4:185651563 MLF1IP 0.81 10.67 0.5 4.48e-23 Blood protein levels; LUSC cis rs1506636 1.000 rs2429619 chr7:123425599 C/G cg03229431 chr7:123269106 ASB15 0.65 10.59 0.5 8.63e-23 Plateletcrit;Platelet count; LUSC trans rs10838798 0.523 rs2019093 chr11:48196553 G/A cg15704280 chr7:45808275 SEPT13 -0.43 -5.98 -0.31 5.62e-9 Height; LUSC cis rs55675132 0.833 rs7542335 chr1:115639374 G/A cg01522456 chr1:115632236 TSPAN2 -0.45 -5.86 -0.31 1.09e-8 Schizophrenia; LUSC cis rs17270561 0.609 rs9348694 chr6:25753640 C/T cg17691542 chr6:26056736 HIST1H1C 0.58 8.18 0.41 6.06e-15 Iron status biomarkers; LUSC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21659725 chr3:3221576 CRBN -0.89 -18.1 -0.7 1.6e-51 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs757081 0.533 rs7949405 chr11:17085192 A/C cg15084286 chr11:17036142 PLEKHA7 0.46 5.92 0.31 8.07e-9 Systolic blood pressure; LUSC cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -6.15 -0.32 2.22e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7223966 0.883 rs2955250 chr17:61959740 C/T cg11494091 chr17:61959527 GH2 0.37 6.21 0.32 1.54e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs826838 0.585 rs4363678 chr12:38624514 G/A cg26384229 chr12:38710491 ALG10B 0.59 8.84 0.44 5.5e-17 Heart rate; LUSC cis rs868036 0.609 rs2127163 chr15:68090842 C/T cg08079166 chr15:68083412 MAP2K5 0.49 8.01 0.4 1.89e-14 Restless legs syndrome; LUSC cis rs7843479 0.965 rs13278159 chr8:21799737 C/A cg17168535 chr8:21777572 XPO7 0.68 10.63 0.5 6.09e-23 Mean corpuscular volume; LUSC cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg02187348 chr16:89574699 SPG7 -0.45 -6.73 -0.35 7.55e-11 Multiple myeloma (IgH translocation); LUSC trans rs1997103 0.834 rs10274457 chr7:55390199 G/A cg20935933 chr6:143382018 AIG1 0.5 7.18 0.37 4.55e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs6598955 0.671 rs6686100 chr1:26617338 G/C cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.76 -0.43 9.89e-17 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25319031 chr3:119813310 GSK3B -0.4 -5.97 -0.31 6.03e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg00343986 chr7:65444356 GUSB -0.44 -6.76 -0.35 6.29e-11 Aortic root size; LUSC cis rs13202913 0.652 rs9371528 chr6:151832668 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.52 5.7 0.3 2.69e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg26408565 chr15:76604113 ETFA -0.47 -7.42 -0.38 9.75e-13 Blood metabolite levels; LUSC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg08045932 chr20:61659980 NA 0.59 10.4 0.49 3.85e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 8.86 0.44 4.9e-17 Alzheimer's disease; LUSC cis rs9815354 0.812 rs17218264 chr3:41975847 C/T cg03022575 chr3:42003672 ULK4 -0.81 -9.01 -0.44 1.66e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs9640161 0.830 rs1051823 chr7:150070814 G/A cg27494647 chr7:150038898 RARRES2 0.36 5.82 0.3 1.35e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg17385448 chr1:15911702 AGMAT 0.37 6.4 0.33 5.16e-10 Systolic blood pressure; LUSC cis rs9660992 0.512 rs12142402 chr1:205128215 A/T cg00857998 chr1:205179979 DSTYK 0.67 10.55 0.5 1.19e-22 Mean corpuscular volume;Mean platelet volume; LUSC trans rs1728785 1.000 rs821167 chr16:68577222 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.73 0.39 1.27e-13 Ulcerative colitis; LUSC cis rs79149102 0.579 rs8039433 chr15:75367367 T/C cg09165964 chr15:75287851 SCAMP5 -0.72 -6.56 -0.34 2.05e-10 Lung cancer; LUSC cis rs11098499 0.820 rs28535956 chr4:120536858 C/T cg09307838 chr4:120376055 NA -0.72 -10.38 -0.49 4.55e-22 Corneal astigmatism; LUSC cis rs478304 0.593 rs9666878 chr11:65475816 A/C cg05805236 chr11:65401703 PCNXL3 0.61 10.09 0.48 4.67e-21 Acne (severe); LUSC cis rs8017423 1.000 rs2183189 chr14:90670057 A/G cg04374321 chr14:90722782 PSMC1 0.7 10.93 0.51 5.62e-24 Mortality in heart failure; LUSC cis rs9790314 1.000 rs1600209 chr3:161038217 A/T cg04691961 chr3:161091175 C3orf57 -0.36 -6.12 -0.32 2.6e-9 Morning vs. evening chronotype; LUSC cis rs13191362 0.507 rs7772787 chr6:163190981 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.36 6.48 0.33 3.34e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08616760 chr5:178157801 ZNF354A 0.43 6.71 0.34 8.12e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.67e-9 Monocyte count; LUSC cis rs9549367 0.789 rs7999579 chr13:113879357 T/C cg00898013 chr13:113819073 PROZ -0.56 -8.06 -0.4 1.36e-14 Platelet distribution width; LUSC cis rs600231 0.623 rs3015966 chr11:65217589 T/C cg21890820 chr11:65308645 LTBP3 0.48 7.03 0.36 1.2e-11 Bone mineral density; LUSC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.74 0.3 2.08e-8 Cerebrospinal P-tau181p levels; LUSC cis rs7191439 0.858 rs7205626 chr16:88780472 T/C cg02389323 chr16:88786976 FAM38A 1.11 11.41 0.53 1.14e-25 Plateletcrit; LUSC cis rs11098499 0.739 rs10013032 chr4:120149419 C/T cg24375607 chr4:120327624 NA -0.69 -10.9 -0.51 6.88e-24 Corneal astigmatism; LUSC cis rs2303282 0.865 rs370151 chr16:56561494 G/T cg00500540 chr16:56394104 NA -0.43 -7.03 -0.36 1.21e-11 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00771490 chr12:65008851 RASSF3 -0.48 -7.17 -0.37 4.97e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.81 -14.68 -0.63 5.44e-38 Age at first birth; LUSC cis rs7804356 1.000 rs7785711 chr7:26861640 G/A cg03456212 chr7:26904342 SKAP2 -0.52 -6.08 -0.32 3.24e-9 Type 1 diabetes; LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg07677032 chr17:61819896 STRADA 0.51 8.63 0.43 2.53e-16 Prudent dietary pattern; LUSC cis rs11690935 0.959 rs6705200 chr2:172637600 A/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -15.18 -0.64 6.12e-40 Schizophrenia; LUSC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg20790798 chr5:1857306 NA -0.46 -7.99 -0.4 2.25e-14 Cardiovascular disease risk factors; LUSC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg12257692 chr3:49977190 RBM6 0.23 6.35 0.33 7.21e-10 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg05347473 chr6:146136440 FBXO30 0.5 8.36 0.42 1.77e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg11764359 chr7:65958608 NA 0.66 10.23 0.49 1.5e-21 Aortic root size; LUSC cis rs6580649 0.783 rs1635526 chr12:48396785 C/T cg05342945 chr12:48394962 COL2A1 -0.45 -6.04 -0.31 4.21e-9 Lung cancer; LUSC cis rs9549367 0.774 rs2287246 chr13:113889127 A/G cg00898013 chr13:113819073 PROZ -0.56 -8.07 -0.4 1.29e-14 Platelet distribution width; LUSC cis rs7918232 0.567 rs4749215 chr10:27312005 T/C cg14442939 chr10:27389572 ANKRD26 0.51 5.97 0.31 6.07e-9 Breast cancer; LUSC cis rs7577696 0.962 rs12617289 chr2:32341399 A/G cg02381751 chr2:32503542 YIPF4 -0.4 -5.71 -0.3 2.5e-8 Inflammatory biomarkers; LUSC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg21963583 chr11:68658836 MRPL21 0.56 8.4 0.42 1.26e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs62458065 0.850 rs10273165 chr7:32460840 G/A cg00845942 chr12:64062724 DPY19L2 -0.53 -6.25 -0.32 1.28e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2985334 1.000 rs2993715 chr1:29356050 C/G cg05928980 chr1:29567425 PTPRU 0.33 5.69 0.3 2.84e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg16447950 chr5:562315 NA -0.56 -6.88 -0.35 2.88e-11 Obesity-related traits; LUSC cis rs7937890 1.000 rs7937890 chr11:14396485 C/T cg19336497 chr11:14380999 RRAS2 -0.39 -7.33 -0.37 1.72e-12 Mitochondrial DNA levels; LUSC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg05973401 chr12:123451056 ABCB9 0.54 6.68 0.34 1.01e-10 Neutrophil percentage of white cells; LUSC cis rs826838 0.967 rs980572 chr12:39127673 A/C cg13010199 chr12:38710504 ALG10B 0.61 10.27 0.49 1.14e-21 Heart rate; LUSC cis rs10904908 1.000 rs10904908 chr10:17260290 A/G cg01003015 chr10:17271136 VIM -0.42 -6.06 -0.31 3.73e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs7107174 1.000 rs10793304 chr11:78064907 A/G cg02023728 chr11:77925099 USP35 0.44 6.64 0.34 1.3e-10 Testicular germ cell tumor; LUSC cis rs4319547 0.585 rs7952868 chr12:122846949 A/G cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.6 -0.43 3.09e-16 Body mass index; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg15112475 chr7:1198522 ZFAND2A -0.31 -6.21 -0.32 1.57e-9 Longevity;Endometriosis; LUSC cis rs34779708 0.931 rs4934720 chr10:35376800 T/C cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1801251 1.000 rs1947105 chr2:233721455 A/G cg08000102 chr2:233561755 GIGYF2 0.68 11.39 0.53 1.25e-25 Coronary artery disease; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.9 0.44 3.49e-17 Prudent dietary pattern; LUSC cis rs2295359 0.892 rs72676058 chr1:67627681 C/A cg12940439 chr1:67600707 NA 0.37 5.98 0.31 5.76e-9 Psoriasis; LUSC cis rs67366981 1.000 rs55923743 chr14:77711454 G/A cg22824376 chr14:77648248 TMEM63C 0.65 6.19 0.32 1.75e-9 Obsessive-compulsive symptoms; LUSC cis rs4629180 0.586 rs1509497 chr2:102138184 C/T cg01388757 chr2:102091195 RFX8 -0.36 -6.26 -0.32 1.19e-9 Chronic rhinosinusitis with nasal polyps; LUSC cis rs763121 0.813 rs2179143 chr22:39037984 A/G cg06544989 chr22:39130855 UNC84B 0.33 5.75 0.3 1.99e-8 Menopause (age at onset); LUSC cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg22681709 chr2:178499509 PDE11A -0.51 -8.94 -0.44 2.61e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg15556689 chr8:8085844 FLJ10661 -0.67 -10.72 -0.51 3.16e-23 Joint mobility (Beighton score); LUSC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg23172400 chr8:95962367 TP53INP1 0.35 6.7 0.34 8.71e-11 Type 2 diabetes; LUSC cis rs9399135 0.967 rs9373122 chr6:135373534 G/A cg24558204 chr6:135376177 HBS1L 0.57 8.81 0.43 6.87e-17 Red blood cell count; LUSC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg22857025 chr5:266934 NA -1.17 -16.85 -0.68 1.53e-46 Breast cancer; LUSC cis rs10789491 0.951 rs35050319 chr1:47103886 C/A cg15501359 chr1:47185051 KIAA0494 -0.81 -11.09 -0.52 1.47e-24 Response to hepatitis C treatment; LUSC trans rs3942852 0.568 rs1039484 chr11:48097948 A/G cg03929089 chr4:120376271 NA -0.58 -7.49 -0.38 6.14e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs9527 0.544 rs1572578 chr10:104822431 C/G cg05855489 chr10:104503620 C10orf26 0.53 8.01 0.4 1.98e-14 Arsenic metabolism; LUSC cis rs9650657 0.812 rs11250073 chr8:10632236 G/T cg27411982 chr8:10470053 RP1L1 -0.4 -6.43 -0.33 4.37e-10 Neuroticism; LUSC cis rs113835537 0.597 rs2075792 chr11:66334556 G/A cg24851651 chr11:66362959 CCS 0.57 8.83 0.43 6.06e-17 Airway imaging phenotypes; LUSC cis rs617219 0.819 rs2607145 chr5:78552400 A/G cg24856658 chr5:78533917 JMY -0.3 -5.88 -0.31 9.86e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg23583168 chr7:148888333 NA -0.91 -17.45 -0.69 6.14e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg08807101 chr21:30365312 RNF160 0.75 13.45 0.59 3.03e-33 Dental caries; LUSC cis rs7917772 0.582 rs10883738 chr10:104321721 T/C cg22532475 chr10:104410764 TRIM8 -0.26 -6.07 -0.32 3.47e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs8062405 1.000 rs12446589 chr16:28870962 G/A cg05966235 chr16:28915196 ATP2A1 0.34 5.96 0.31 6.41e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2854207 0.505 rs2466957 chr17:61961230 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 7.16 0.36 5.23e-12 Height; LUSC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg18876405 chr7:65276391 NA 0.58 9.57 0.46 2.55e-19 Aortic root size; LUSC cis rs4512344 0.509 rs2409784 chr8:11396856 G/T cg21775007 chr8:11205619 TDH -0.53 -7.99 -0.4 2.22e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs11610422 1.000 rs12824814 chr12:31414473 G/T cg14306366 chr12:31406441 NA -0.51 -6.25 -0.32 1.25e-9 Coronary artery disease; LUSC cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.5 7.46 0.38 7.66e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg14092988 chr3:52407081 DNAH1 0.33 6.32 0.33 8.52e-10 Bipolar disorder; LUSC cis rs524023 0.958 rs3825016 chr11:64359286 C/T cg19131476 chr11:64387923 NRXN2 -0.37 -10.05 -0.48 5.96e-21 Urate levels in obese individuals; LUSC cis rs926938 0.527 rs360678 chr1:115493902 T/A cg01522456 chr1:115632236 TSPAN2 -0.42 -6.5 -0.34 2.95e-10 Autism; LUSC cis rs9677476 0.821 rs6731682 chr2:232106245 G/C cg07929768 chr2:232055508 NA 0.33 6.26 0.32 1.2e-9 Food antigen IgG levels; LUSC cis rs611744 0.647 rs585077 chr8:109245497 C/T cg21045802 chr8:109455806 TTC35 0.42 6.56 0.34 2.04e-10 Dupuytren's disease; LUSC cis rs10791097 0.667 rs2155358 chr11:130740357 T/C cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07581978 chr13:80917058 NA -0.5 -6.01 -0.31 4.77e-9 Bipolar disorder and schizophrenia; LUSC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg27129171 chr3:47204927 SETD2 0.57 8.14 0.41 8.17e-15 Birth weight; LUSC cis rs7296418 0.630 rs11057238 chr12:123767971 C/A cg00376283 chr12:123451042 ABCB9 0.69 10.66 0.5 4.96e-23 Platelet count; LUSC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg25036284 chr2:26402008 FAM59B -0.68 -9.64 -0.47 1.49e-19 Gut microbiome composition (summer); LUSC cis rs300703 0.719 rs389621 chr2:206636 C/T cg21211680 chr2:198530 NA -0.64 -7.22 -0.37 3.57e-12 Blood protein levels; LUSC cis rs10504229 0.636 rs114725691 chr8:58054292 C/T cg08219700 chr8:58056026 NA 0.47 5.95 0.31 6.7e-9 Developmental language disorder (linguistic errors); LUSC cis rs10141207 0.531 rs1547213 chr14:32678646 C/A cg23627301 chr14:32673368 NA 0.52 8.6 0.43 3.11e-16 Asthma; LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg18099408 chr3:52552593 STAB1 -0.42 -7.12 -0.36 6.71e-12 Bipolar disorder; LUSC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg05368731 chr17:41323189 NBR1 0.94 15.86 0.66 1.24e-42 Menopause (age at onset); LUSC cis rs6500602 0.789 rs2404546 chr16:4479734 C/G cg08645402 chr16:4508243 NA 0.53 9.0 0.44 1.71e-17 Schizophrenia; LUSC cis rs7119 0.717 rs12917175 chr15:77818193 A/G cg27398640 chr15:77910606 LINGO1 -0.3 -6.4 -0.33 5.19e-10 Type 2 diabetes; LUSC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg01879757 chr17:41196368 BRCA1 -0.48 -7.64 -0.39 2.37e-13 Menopause (age at onset); LUSC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg16405210 chr4:1374714 KIAA1530 -0.58 -9.02 -0.44 1.47e-17 Longevity; LUSC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg19717773 chr7:2847554 GNA12 -0.34 -5.69 -0.3 2.81e-8 Height; LUSC cis rs377070 0.816 rs309406 chr4:123618707 G/A cg10495464 chr4:123653540 BBS12;LOC729338 0.4 5.89 0.31 9.33e-9 Mosquito bite size; LUSC cis rs7112925 0.738 rs12803688 chr11:66833265 G/A cg24851651 chr11:66362959 CCS -0.36 -6.06 -0.31 3.65e-9 Height; LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.84 -0.57 5.96e-31 Platelet count; LUSC cis rs11039100 0.850 rs12796660 chr11:5843681 T/C cg13902645 chr11:5959945 NA -0.54 -6.01 -0.31 4.72e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2303282 0.716 rs2241956 chr16:56400847 T/C cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg05084668 chr3:125655381 ALG1L -0.5 -7.04 -0.36 1.1e-11 Blood pressure (smoking interaction); LUSC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg22467129 chr15:76604101 ETFA 0.43 6.91 0.35 2.42e-11 Blood metabolite levels; LUSC cis rs7084921 0.578 rs12776318 chr10:101868677 T/G cg11888571 chr10:102027403 CWF19L1 -0.45 -6.12 -0.32 2.56e-9 Bone mineral density; LUSC cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.99 0.31 5.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg18479299 chr3:125709523 NA -0.51 -5.82 -0.3 1.35e-8 Blood pressure (smoking interaction); LUSC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs10986311 0.822 rs10818946 chr9:127116102 A/C cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.42 -7.0 -0.36 1.4e-11 Vitiligo; LUSC cis rs73206853 0.764 rs60339427 chr12:110824471 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs12477438 0.765 rs2309521 chr2:99592069 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.68 -0.57 2.41e-30 Chronic sinus infection; LUSC cis rs77106637 0.860 rs11603334 chr11:72432985 G/A cg03713592 chr11:72463424 ARAP1 1.01 11.41 0.53 1.14e-25 Type 2 diabetes; LUSC cis rs17253792 0.822 rs76557162 chr14:56064701 A/G cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg02782426 chr3:40428986 ENTPD3 0.38 6.65 0.34 1.2e-10 Renal cell carcinoma; LUSC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg17376030 chr22:41985996 PMM1 0.46 5.89 0.31 9.37e-9 Vitiligo; LUSC cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg04850211 chr1:228464232 OBSCN 0.32 5.76 0.3 1.94e-8 Diastolic blood pressure; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18276145 chr4:72052432 SLC4A4 0.82 7.76 0.39 1.04e-13 Cognitive performance; LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg25036284 chr2:26402008 FAM59B 0.67 9.1 0.45 8.39e-18 Gut microbiome composition (summer); LUSC trans rs2055729 0.645 rs12544019 chr8:9742578 T/C cg15556689 chr8:8085844 FLJ10661 0.5 6.34 0.33 7.32e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs559555 0.512 rs655548 chr2:31836658 A/C cg02381751 chr2:32503542 YIPF4 0.41 5.7 0.3 2.57e-8 Blood metabolite ratios;Blood metabolite levels; LUSC trans rs7681440 0.904 rs6817001 chr4:90766019 C/T cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.99 -0.31 5.47e-9 Dementia with Lewy bodies; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg14159672 chr1:205819179 PM20D1 0.85 15.09 0.64 1.33e-39 Menarche (age at onset); LUSC cis rs4663866 1.000 rs71426510 chr2:239178909 T/G cg16914508 chr2:239161102 PER2 0.68 7.15 0.36 5.4e-12 Irritable bowel syndrome; LUSC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.67 -11.43 -0.53 9.53e-26 Total body bone mineral density; LUSC cis rs3760982 0.585 rs67704568 chr19:44294019 T/C cg11993925 chr19:44307056 LYPD5 0.35 7.63 0.39 2.43e-13 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs9640161 0.659 rs7788316 chr7:150013995 A/T cg27494647 chr7:150038898 RARRES2 0.45 6.98 0.36 1.64e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC cis rs12900413 0.687 rs8034777 chr15:90313057 C/T cg24249390 chr15:90295951 MESP1 0.36 5.7 0.3 2.58e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg25767906 chr1:53392781 SCP2 -0.65 -12.85 -0.58 5.69e-31 Monocyte count; LUSC trans rs853679 0.882 rs4713139 chr6:28092685 C/T cg01620082 chr3:125678407 NA -0.6 -6.8 -0.35 4.77e-11 Depression; LUSC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.56 9.55 0.46 2.89e-19 Lymphocyte counts; LUSC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg07507251 chr3:52567010 NT5DC2 0.33 6.46 0.33 3.61e-10 Bipolar disorder; LUSC cis rs9790314 1.000 rs1600209 chr3:161038217 A/T cg03342759 chr3:160939853 NMD3 -0.49 -8.16 -0.41 6.68e-15 Morning vs. evening chronotype; LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 7.07 0.36 9.38e-12 Platelet count; LUSC cis rs7107174 1.000 rs7116611 chr11:78030046 A/G cg02023728 chr11:77925099 USP35 0.47 6.76 0.35 6.17e-11 Testicular germ cell tumor; LUSC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg03684893 chr10:554711 DIP2C 0.35 6.42 0.33 4.71e-10 Psychosis in Alzheimer's disease; LUSC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.08 0.32 3.26e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg11812906 chr14:75593930 NEK9 0.67 11.75 0.54 6.22e-27 Height; LUSC cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg22709100 chr7:91322751 NA 0.39 5.74 0.3 2.13e-8 Breast cancer; LUSC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg18306943 chr3:40428807 ENTPD3 0.4 6.22 0.32 1.48e-9 Renal cell carcinoma; LUSC cis rs12137294 0.866 rs1078362 chr1:205209530 A/G cg00857998 chr1:205179979 DSTYK 0.39 5.73 0.3 2.25e-8 Red cell distribution width; LUSC cis rs10489525 0.599 rs7516121 chr1:115604317 A/G cg01522456 chr1:115632236 TSPAN2 0.5 7.33 0.37 1.8e-12 Autism; LUSC cis rs796364 0.806 rs203769 chr2:200900866 C/T cg23649088 chr2:200775458 C2orf69 -0.57 -7.04 -0.36 1.12e-11 Schizophrenia; LUSC cis rs60154123 0.614 rs4844988 chr1:210459888 C/T cg22029157 chr1:209979665 IRF6 0.52 5.93 0.31 7.46e-9 Coronary artery disease; LUSC cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg05347473 chr6:146136440 FBXO30 0.55 9.35 0.46 1.34e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg26924012 chr15:45694286 SPATA5L1 1.14 19.82 0.74 2.49e-58 Homoarginine levels; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg17178900 chr1:205818956 PM20D1 -0.73 -13.31 -0.59 1.04e-32 Monocyte percentage of white cells; LUSC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg02807482 chr3:125708958 NA -0.49 -6.1 -0.32 3.01e-9 Blood pressure (smoking interaction); LUSC cis rs950169 0.881 rs4842852 chr15:84941961 A/G cg12863693 chr15:85201151 NMB 0.36 7.05 0.36 1.05e-11 Schizophrenia; LUSC cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.58e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs6754311 0.550 rs1438307 chr2:136499166 A/C cg25344623 chr2:136566232 LCT -0.37 -5.73 -0.3 2.28e-8 Mosquito bite size; LUSC cis rs2290416 0.681 rs3793371 chr8:144664299 C/T cg14809332 chr8:144654887 C8orf73 0.5 6.27 0.32 1.12e-9 Attention deficit hyperactivity disorder; LUSC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -8.46 -0.42 8.5e-16 Personality dimensions; LUSC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.45 -0.42 9.43e-16 Lung cancer; LUSC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg16325326 chr1:53192061 ZYG11B -0.88 -16.3 -0.67 2.36e-44 Monocyte count; LUSC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.46 -0.33 3.73e-10 High light scatter reticulocyte count; LUSC cis rs951366 0.576 rs12046305 chr1:205714478 G/A cg11965913 chr1:205819406 PM20D1 -0.49 -6.73 -0.35 7.57e-11 Menarche (age at onset); LUSC cis rs2404602 0.735 rs2468130 chr15:76796496 T/C cg23625390 chr15:77176239 SCAPER -0.55 -8.51 -0.42 5.79e-16 Blood metabolite levels; LUSC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.15 -0.36 5.68e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg00864183 chr17:48045973 DLX4 0.39 6.0 0.31 5.14e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7903847 0.642 rs10882922 chr10:99158537 C/T cg08345082 chr10:99160200 RRP12 -0.35 -7.17 -0.37 4.75e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7615316 0.779 rs9826786 chr3:142146261 A/C cg16271453 chr3:142027066 XRN1 -0.42 -7.22 -0.37 3.51e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2070488 0.861 rs2067082 chr3:38438182 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 13.44 0.59 3.1e-33 Electrocardiographic conduction measures; LUSC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg01448562 chr3:133502909 NA 0.6 10.19 0.49 2.13e-21 Iron status biomarkers; LUSC cis rs1448094 0.706 rs10863149 chr12:86425498 A/T cg18827107 chr12:86230957 RASSF9 -0.4 -6.01 -0.31 4.84e-9 Major depressive disorder; LUSC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg00132208 chr4:10120780 NA 0.35 5.71 0.3 2.49e-8 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg09997546 chr11:8931473 C11orf17;ST5 0.34 7.11 0.36 7.07e-12 Hemoglobin concentration; LUSC trans rs7829975 0.572 rs28730413 chr8:8795447 A/C cg27411982 chr8:10470053 RP1L1 -0.37 -6.19 -0.32 1.73e-9 Mood instability; LUSC cis rs9341835 0.772 rs9294206 chr6:64141201 A/G cg03326410 chr6:64151739 NA -0.37 -6.04 -0.31 4.06e-9 Schizophrenia; LUSC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.66 -8.67 -0.43 1.88e-16 Schizophrenia; LUSC cis rs208520 0.690 rs12213575 chr6:66735989 A/G cg07460842 chr6:66804631 NA 1.1 17.27 0.69 3.24e-48 Exhaled nitric oxide output; LUSC cis rs1003719 0.788 rs9975168 chr21:38450557 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.7 -11.7 -0.54 9.7e-27 Eye color traits; LUSC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs2262909 0.962 rs11673195 chr19:22313814 T/C cg05197062 chr11:11642011 GALNTL4 0.55 7.75 0.39 1.1e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.82 12.4 0.56 2.57e-29 Cognitive test performance; LUSC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg13047869 chr3:10149882 C3orf24 0.43 6.53 0.34 2.46e-10 Alzheimer's disease; LUSC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg03060546 chr3:49711283 APEH 0.7 11.52 0.53 4.57e-26 Resting heart rate; LUSC cis rs9420 0.528 rs7117896 chr11:57388551 G/A cg23127183 chr11:57508653 C11orf31 -0.47 -6.55 -0.34 2.18e-10 Schizophrenia; LUSC cis rs61897795 0.657 rs174590 chr11:61616977 G/C cg06781209 chr11:61594997 FADS2 -0.39 -5.97 -0.31 6.09e-9 Neutrophil count;Sum basophil neutrophil counts; LUSC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.7 -9.84 -0.47 3.09e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg17143192 chr8:8559678 CLDN23 -0.4 -6.12 -0.32 2.57e-9 Mood instability; LUSC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg10560079 chr2:191398806 TMEM194B 0.45 7.44 0.38 8.7e-13 Pulse pressure; LUSC cis rs597539 0.503 rs7131462 chr11:68610143 G/A cg21963583 chr11:68658836 MRPL21 -0.41 -6.78 -0.35 5.57e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg08472276 chr7:1133186 C7orf50;GPER -0.42 -6.84 -0.35 3.86e-11 Longevity;Endometriosis; LUSC cis rs2404602 0.536 rs11072599 chr15:76774508 T/C cg26408565 chr15:76604113 ETFA -0.53 -8.4 -0.42 1.32e-15 Blood metabolite levels; LUSC cis rs12681287 0.640 rs7816275 chr8:87373404 A/G cg00550725 chr8:87521180 FAM82B -0.43 -5.7 -0.3 2.65e-8 Caudate activity during reward; LUSC cis rs5769765 0.913 rs28670284 chr22:50221973 C/T cg26441486 chr22:50317300 CRELD2 0.46 6.53 0.34 2.41e-10 Schizophrenia; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg04790936 chr22:38035753 SH3BP1 0.46 6.23 0.32 1.36e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9494145 0.838 rs9494142 chr6:135431640 T/C cg22676075 chr6:135203613 NA 0.58 7.68 0.39 1.84e-13 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; LUSC cis rs9325144 0.671 rs12818797 chr12:39019409 A/G cg26384229 chr12:38710491 ALG10B -0.63 -9.68 -0.47 1.07e-19 Morning vs. evening chronotype; LUSC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.71 0.34 8.52e-11 Lung cancer; LUSC cis rs9467773 0.595 rs6907924 chr6:26438817 T/G cg09904177 chr6:26538194 HMGN4 -0.56 -8.68 -0.43 1.81e-16 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg21782813 chr7:2030301 MAD1L1 0.55 9.52 0.46 3.5e-19 Bipolar disorder and schizophrenia; LUSC cis rs1707322 0.638 rs9429095 chr1:46603348 A/C cg06784218 chr1:46089804 CCDC17 -0.36 -6.7 -0.34 8.85e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7582180 0.629 rs11694642 chr2:100957813 A/G cg08017756 chr2:100939284 LONRF2 -0.47 -8.7 -0.43 1.49e-16 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg25072359 chr17:41440525 NA 0.66 9.34 0.45 1.43e-18 Menopause (age at onset); LUSC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg03806693 chr22:41940476 POLR3H -0.79 -11.74 -0.54 7.06e-27 Vitiligo; LUSC cis rs8114671 0.933 rs6087683 chr20:33774444 C/T cg24642439 chr20:33292090 TP53INP2 0.41 5.97 0.31 5.95e-9 Height; LUSC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.5 7.89 0.4 4.47e-14 Bipolar disorder; LUSC cis rs1728785 1.000 rs698712 chr16:68561879 G/A cg02508848 chr16:68573721 ZFP90 -0.43 -5.89 -0.31 9.61e-9 Ulcerative colitis; LUSC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg20849893 chr7:64541193 NA 0.45 6.45 0.33 3.92e-10 Calcium levels; LUSC cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 0.4 6.48 0.33 3.39e-10 IgG glycosylation; LUSC cis rs6723226 0.842 rs2754522 chr2:32801257 C/G cg02381751 chr2:32503542 YIPF4 0.58 8.7 0.43 1.5e-16 Intelligence (multi-trait analysis); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22225685 chr22:38203998 GCAT -0.47 -6.2 -0.32 1.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs11190604 1.000 rs9420782 chr10:102235015 G/A cg16342193 chr10:102329863 NA -0.33 -6.11 -0.32 2.83e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg18876405 chr7:65276391 NA 0.56 8.84 0.44 5.78e-17 Aortic root size; LUSC cis rs713587 0.719 rs58048722 chr2:25187825 C/T cg01884057 chr2:25150051 NA -0.38 -8.57 -0.42 4.02e-16 Body mass index in non-asthmatics; LUSC cis rs951366 0.576 rs12046305 chr1:205714478 G/A cg14893161 chr1:205819251 PM20D1 -0.48 -6.47 -0.33 3.54e-10 Menarche (age at onset); LUSC cis rs952623 0.649 rs13242896 chr7:39070062 A/G cg15212455 chr7:39170539 POU6F2 0.37 6.06 0.31 3.61e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg11965913 chr1:205819406 PM20D1 0.81 16.54 0.67 2.58e-45 Monocyte percentage of white cells; LUSC cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC cis rs721399 0.539 rs2898476 chr8:18266924 G/A cg18736775 chr8:18248649 NAT2 -0.57 -6.47 -0.33 3.42e-10 Blood metabolite levels; LUSC cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg05347473 chr6:146136440 FBXO30 -0.56 -9.71 -0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg04025307 chr7:1156635 C7orf50 0.53 8.43 0.42 1.07e-15 Longevity;Endometriosis; LUSC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs897984 0.572 rs4889526 chr16:31030344 C/A cg02466173 chr16:30829666 NA -0.53 -10.24 -0.49 1.43e-21 Dementia with Lewy bodies; LUSC cis rs7267979 0.753 rs400357 chr20:25479058 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.77 16.03 0.66 2.63e-43 Liver enzyme levels (alkaline phosphatase); LUSC trans rs7819412 0.595 rs10503416 chr8:10987553 C/T cg15556689 chr8:8085844 FLJ10661 0.43 6.17 0.32 1.95e-9 Triglycerides; LUSC cis rs2439831 0.867 rs2470134 chr15:43849886 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.87 -9.29 -0.45 2.08e-18 Lung cancer in ever smokers; LUSC cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg06808227 chr14:105710500 BRF1 -0.66 -10.19 -0.49 2.02e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs9905704 0.633 rs2680712 chr17:56509865 C/T cg19466818 chr17:56409534 MIR142 -0.3 -5.99 -0.31 5.5e-9 Testicular germ cell tumor; LUSC cis rs9399135 0.967 rs7741626 chr6:135314182 C/T cg24558204 chr6:135376177 HBS1L 0.59 9.12 0.45 7.4e-18 Red blood cell count; LUSC trans rs2243480 1.000 rs36068983 chr7:65408991 C/T cg10756647 chr7:56101905 PSPH 0.86 8.4 0.42 1.27e-15 Diabetic kidney disease; LUSC cis rs28785552 1.000 rs28785552 chr19:53234161 G/A cg22067481 chr19:53234126 ZNF611 -0.48 -6.46 -0.33 3.78e-10 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg02018176 chr4:1364513 KIAA1530 0.55 9.67 0.47 1.13e-19 Longevity; LUSC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg11752832 chr7:134001865 SLC35B4 0.51 7.75 0.39 1.09e-13 Mean platelet volume; LUSC cis rs11214589 0.651 rs17600713 chr11:113259947 C/T cg14159747 chr11:113255604 NA 0.3 7.79 0.39 8.61e-14 Neuroticism; LUSC cis rs2262909 0.962 rs411020 chr19:22231102 G/A cg11619707 chr19:22235551 ZNF257 -0.38 -5.7 -0.3 2.7e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs11718455 0.960 rs1852037 chr3:44003720 G/T cg08738300 chr3:44038990 NA -0.7 -10.39 -0.49 4.18e-22 Coronary artery disease; LUSC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg04352962 chr1:209979756 IRF6 0.52 5.79 0.3 1.65e-8 Cleft lip with or without cleft palate; LUSC trans rs11098499 0.863 rs58452170 chr4:120459674 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.68 0.34 9.76e-11 Corneal astigmatism; LUSC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg11645453 chr3:52864694 ITIH4 0.34 8.08 0.4 1.21e-14 Electroencephalogram traits; LUSC cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.06e-12 Motion sickness; LUSC cis rs7074356 0.569 rs17102596 chr10:82035173 T/C cg27171509 chr10:82033454 MAT1A -0.31 -5.67 -0.3 3.08e-8 Borderline personality disorder; LUSC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg12257692 chr3:49977190 RBM6 0.24 6.69 0.34 9.19e-11 Body mass index; LUSC cis rs9549367 0.713 rs2146750 chr13:113822530 A/G cg00898013 chr13:113819073 PROZ 0.55 7.65 0.39 2.24e-13 Platelet distribution width; LUSC cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg09479241 chr17:27052676 TLCD1 0.43 5.96 0.31 6.29e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg00599273 chr12:58146742 CDK4 0.31 5.8 0.3 1.51e-8 Multiple sclerosis; LUSC cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.25 0.59 1.67e-32 Chronic sinus infection; LUSC cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg21573476 chr21:45109991 RRP1B -0.38 -6.14 -0.32 2.32e-9 Mean corpuscular volume; LUSC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg09998033 chr7:158218633 PTPRN2 0.57 9.29 0.45 1.98e-18 Obesity-related traits; LUSC cis rs61931739 0.635 rs1825746 chr12:33939984 C/T cg06521331 chr12:34319734 NA -0.41 -6.74 -0.35 7.17e-11 Morning vs. evening chronotype; LUSC cis rs7937682 0.889 rs1940529 chr11:111498523 G/C cg19812747 chr11:111475976 SIK2 -0.52 -7.34 -0.37 1.67e-12 Primary sclerosing cholangitis; LUSC cis rs477692 0.905 rs508360 chr10:131424969 A/G cg05714579 chr10:131428358 MGMT 0.52 7.95 0.4 2.84e-14 Response to temozolomide; LUSC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg21963583 chr11:68658836 MRPL21 0.56 8.33 0.41 2.15e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs3862260 0.905 rs3850870 chr1:120161037 C/T cg11530693 chr1:120165357 ZNF697 0.51 7.92 0.4 3.49e-14 Systemic lupus erythematosus; LUSC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 8.88 0.44 4.31e-17 Alzheimer's disease; LUSC cis rs35146811 0.735 rs1637001 chr7:99808151 G/A cg22906224 chr7:99728672 NA -0.47 -6.56 -0.34 2.03e-10 Coronary artery disease; LUSC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.59 0.34 1.76e-10 Lung cancer; LUSC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.81 9.59 0.46 2.2e-19 Mean platelet volume; LUSC cis rs9902453 0.967 rs12150261 chr17:28320473 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -8.3 -0.41 2.68e-15 Coffee consumption (cups per day); LUSC trans rs8072100 1.000 rs8065669 chr17:45724996 G/A cg04995722 chr7:26192034 NFE2L3 -0.36 -5.95 -0.31 6.69e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6484504 0.576 rs9971609 chr11:31434104 C/T cg06552810 chr11:31128660 NA 0.35 6.11 0.32 2.74e-9 Red blood cell count; LUSC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg06481639 chr22:41940642 POLR3H -0.5 -5.69 -0.3 2.78e-8 Vitiligo; LUSC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg11764359 chr7:65958608 NA 0.62 9.22 0.45 3.56e-18 Calcium levels; LUSC cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg02574844 chr11:5959923 NA -0.48 -6.76 -0.35 6.32e-11 DNA methylation (variation); LUSC trans rs4729127 1.000 rs57515158 chr7:94007842 T/G cg14660007 chr13:78271894 SLAIN1 0.49 6.25 0.32 1.27e-9 Intelligence; LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.03 -0.31 4.28e-9 Platelet count; LUSC cis rs11657217 1.000 rs11657217 chr17:77709339 C/G cg06901238 chr17:77706717 ENPP7 0.57 11.09 0.52 1.48e-24 Diastolic blood pressure response to hydrochlorothiazide in hypertension; LUSC cis rs2579519 0.547 rs2463560 chr2:96595589 T/C cg22654517 chr2:96458247 NA 0.34 6.82 0.35 4.29e-11 Diastolic blood pressure; LUSC cis rs7193541 0.550 rs28607667 chr16:74476015 C/T cg01733217 chr16:74700730 RFWD3 -0.67 -10.2 -0.49 1.92e-21 Multiple myeloma; LUSC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg27211696 chr2:191398769 TMEM194B -0.61 -11.79 -0.54 4.45e-27 Pulse pressure; LUSC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg14668632 chr7:2872130 GNA12 -0.47 -6.82 -0.35 4.29e-11 Height; LUSC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg16680214 chr1:154839983 KCNN3 0.51 9.45 0.46 6.06e-19 Prostate cancer; LUSC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg05623727 chr3:50126028 RBM5 -0.33 -6.18 -0.32 1.86e-9 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.89 0.55 1.95e-27 Prudent dietary pattern; LUSC cis rs2730245 0.527 rs2709858 chr7:158675266 C/G cg24397884 chr7:158709396 WDR60 0.8 8.96 0.44 2.31e-17 Height; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg19393281 chr3:50606861 HEMK1 -0.41 -6.14 -0.32 2.31e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg09877947 chr5:131593287 PDLIM4 -0.42 -6.85 -0.35 3.57e-11 Breast cancer; LUSC cis rs3820928 0.874 rs10166736 chr2:227900419 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.97 -0.4 2.58e-14 Pulmonary function; LUSC cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg23711669 chr6:146136114 FBXO30 0.82 14.37 0.62 8.27e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs3096299 0.838 rs4785561 chr16:89429052 C/T cg06640241 chr16:89574553 SPG7 0.6 9.13 0.45 6.69e-18 Multiple myeloma (IgH translocation); LUSC cis rs7119 0.651 rs12902898 chr15:77849191 A/G cg27398640 chr15:77910606 LINGO1 -0.3 -5.94 -0.31 7.14e-9 Type 2 diabetes; LUSC cis rs7202877 0.706 rs8046184 chr16:75411725 T/C cg03315344 chr16:75512273 CHST6 0.44 6.48 0.33 3.35e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg17724175 chr1:150552817 MCL1 0.35 6.52 0.34 2.59e-10 Tonsillectomy; LUSC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg27266027 chr21:40555129 PSMG1 -0.4 -5.88 -0.31 9.82e-9 Cognitive function; LUSC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg11764359 chr7:65958608 NA -0.71 -11.04 -0.52 2.31e-24 Aortic root size; LUSC cis rs13401104 0.796 rs1530955 chr2:237111003 C/T cg19324714 chr2:237145437 ASB18 0.44 5.97 0.31 6.01e-9 Educational attainment; LUSC trans rs61931739 0.926 rs1995966 chr12:34095420 G/A cg13010199 chr12:38710504 ALG10B -0.41 -6.07 -0.32 3.52e-9 Morning vs. evening chronotype; LUSC cis rs6121246 0.567 rs6060247 chr20:30190720 C/G cg18721089 chr20:30220636 NA -0.36 -5.64 -0.3 3.54e-8 Mean corpuscular hemoglobin; LUSC cis rs9875589 0.509 rs9824910 chr3:14040136 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 7.01 0.36 1.32e-11 Ovarian reserve; LUSC cis rs4268898 0.722 rs6723257 chr2:24391129 A/G cg06627628 chr2:24431161 ITSN2 0.54 7.47 0.38 7.13e-13 Asthma; LUSC trans rs2243480 1.000 rs10807702 chr7:65767843 C/T cg10756647 chr7:56101905 PSPH 0.81 8.09 0.4 1.15e-14 Diabetic kidney disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg20410673 chr18:43684340 HAUS1;ATP5A1 0.45 6.03 0.31 4.42e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs17001868 0.568 rs2294350 chr22:40784278 C/T cg07138101 chr22:40742427 ADSL 0.62 7.28 0.37 2.41e-12 Mammographic density (dense area); LUSC cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg08999081 chr20:33150536 PIGU 0.42 7.28 0.37 2.47e-12 Coronary artery disease; LUSC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9653442 0.545 rs1821826 chr2:100764711 C/T cg22139774 chr2:100720529 AFF3 -0.42 -7.25 -0.37 2.9e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs721399 0.568 rs35942058 chr8:18274398 G/A cg18736775 chr8:18248649 NAT2 -0.56 -7.0 -0.36 1.43e-11 Blood metabolite levels; LUSC cis rs79976124 0.879 rs77185357 chr6:66629070 G/A cg07460842 chr6:66804631 NA 0.68 8.41 0.42 1.25e-15 Type 2 diabetes; LUSC trans rs17266958 1.000 rs62576987 chr9:83295961 C/T cg01905489 chr1:26616534 UBXN11 -0.58 -6.38 -0.33 6.04e-10 Preschool internalizing problems; LUSC cis rs7772486 0.846 rs2748496 chr6:146321829 T/A cg13319975 chr6:146136371 FBXO30 -0.47 -6.89 -0.35 2.79e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.63 -0.34 1.33e-10 Alzheimer's disease (late onset); LUSC cis rs2985684 0.894 rs4900932 chr14:50022928 A/G cg04989706 chr14:50066350 PPIL5 -0.47 -6.1 -0.32 2.92e-9 Carotid intima media thickness; LUSC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2439831 0.681 rs1549523 chr15:43624189 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.92 10.84 0.51 1.16e-23 Lung cancer in ever smokers; LUSC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.69 0.43 1.64e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs10435719 0.647 rs10092605 chr8:11787395 T/G cg00405596 chr8:11794950 NA 0.35 5.94 0.31 7.12e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg25767906 chr1:53392781 SCP2 0.48 8.63 0.43 2.55e-16 Monocyte count; LUSC cis rs2235642 0.821 rs2281236 chr16:1603576 G/A cg26528668 chr16:1614120 IFT140 0.47 8.13 0.41 8.24e-15 Coronary artery disease; LUSC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg15445000 chr17:37608096 MED1 -0.39 -6.69 -0.34 9.56e-11 Glomerular filtration rate (creatinine); LUSC cis rs6681460 0.932 rs665319 chr1:67175488 A/G cg02459107 chr1:67143332 SGIP1 0.47 8.79 0.43 8.09e-17 Presence of antiphospholipid antibodies; LUSC cis rs56283067 0.578 rs1321079 chr6:45358403 T/A cg20913747 chr6:44695427 NA -0.43 -6.31 -0.33 8.84e-10 Total body bone mineral density; LUSC trans rs61931739 0.591 rs1608907 chr12:33945435 A/G cg13010199 chr12:38710504 ALG10B 0.41 6.19 0.32 1.72e-9 Morning vs. evening chronotype; LUSC cis rs897080 0.552 rs1067323 chr2:44630018 T/G cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs11785400 0.762 rs9694556 chr8:143727841 A/G cg24634471 chr8:143751801 JRK 0.5 7.08 0.36 8.65e-12 Schizophrenia; LUSC cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.39 0.33 5.53e-10 Rheumatoid arthritis; LUSC cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.43 5.76 0.3 1.9e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs240768 1.000 rs240777 chr6:101003215 G/A cg12253828 chr6:101329408 ASCC3 0.84 5.74 0.3 2.11e-8 Economic and political preferences (immigration/crime); LUSC cis rs75920871 0.660 rs12271161 chr11:116979911 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.49 -6.06 -0.31 3.76e-9 Subjective well-being; LUSC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.13 0.36 6.34e-12 Bipolar disorder; LUSC cis rs243505 0.867 rs243526 chr7:148417073 C/T cg09806900 chr7:148480153 CUL1 -0.48 -6.82 -0.35 4.34e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg13732083 chr21:47605072 C21orf56 0.45 6.73 0.35 7.22e-11 Testicular germ cell tumor; LUSC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg09021430 chr5:549028 NA -0.57 -7.76 -0.39 1.05e-13 Obesity-related traits; LUSC cis rs372883 0.638 rs117213 chr21:30720536 G/A cg24692254 chr21:30365293 RNF160 -0.68 -10.49 -0.5 1.87e-22 Pancreatic cancer; LUSC cis rs9868809 0.772 rs12107252 chr3:48691316 T/C cg00383909 chr3:49044727 WDR6 0.81 7.55 0.38 4.26e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs79481398 0.584 rs11856034 chr15:57778324 A/G cg19997606 chr15:57842346 CGNL1 -0.42 -5.78 -0.3 1.71e-8 Facial morphology (factor 19); LUSC cis rs9300255 0.602 rs2682431 chr12:123703226 T/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.1 -0.32 2.96e-9 Neutrophil percentage of white cells; LUSC cis rs12368653 0.582 rs2307095 chr12:58026001 G/A cg12615879 chr12:58013172 SLC26A10 0.42 9.91 0.48 1.87e-20 Multiple sclerosis; LUSC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs17253792 0.732 rs28380739 chr14:56088402 G/A cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs11785400 0.793 rs4336593 chr8:143739647 A/C cg24634471 chr8:143751801 JRK -0.51 -7.26 -0.37 2.82e-12 Schizophrenia; LUSC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg02475777 chr4:1388615 CRIPAK -0.42 -6.16 -0.32 2.05e-9 Obesity-related traits; LUSC cis rs208520 0.874 rs208515 chr6:66945749 A/G cg07460842 chr6:66804631 NA -1.01 -14.32 -0.62 1.29e-36 Exhaled nitric oxide output; LUSC cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg03146154 chr1:46216737 IPP 0.53 7.68 0.39 1.75e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9322193 0.886 rs4870049 chr6:150158194 G/T cg00933542 chr6:150070202 PCMT1 0.33 6.73 0.35 7.34e-11 Lung cancer; LUSC cis rs4285028 0.747 rs77790376 chr3:121492211 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -12.35 -0.56 4.18e-29 Multiple sclerosis; LUSC trans rs4729127 0.908 rs10464486 chr7:93983851 A/G cg20086523 chr13:52378287 DHRS12 0.57 6.12 0.32 2.64e-9 Intelligence; LUSC cis rs12956009 0.559 rs12607072 chr18:44839888 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.23 0.32 1.4e-9 Educational attainment (years of education); LUSC cis rs9653442 0.527 rs2118280 chr2:100746395 G/A cg22139774 chr2:100720529 AFF3 -0.41 -6.93 -0.35 2.13e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9517313 0.615 rs4772079 chr13:99090837 C/G cg07423050 chr13:99094983 FARP1 -0.66 -15.34 -0.64 1.36e-40 Neuroticism; LUSC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 9.03 0.44 1.42e-17 Prudent dietary pattern; LUSC cis rs734999 0.588 rs876938 chr1:2523212 G/C cg18854424 chr1:2615690 NA 0.48 9.53 0.46 3.32e-19 Ulcerative colitis; LUSC trans rs11098499 0.955 rs6815725 chr4:120158410 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.16 0.32 2.03e-9 Corneal astigmatism; LUSC cis rs6692729 0.769 rs12758915 chr1:227058344 A/G cg10327440 chr1:227177885 CDC42BPA 0.49 7.02 0.36 1.24e-11 Electrodermal activity; LUSC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg23711669 chr6:146136114 FBXO30 0.9 17.11 0.68 1.48e-47 Lobe attachment (rater-scored or self-reported); LUSC trans rs11039798 0.544 rs113253936 chr11:48160609 C/T cg15704280 chr7:45808275 SEPT13 0.79 6.1 0.32 3.02e-9 Axial length; LUSC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.06e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs9517320 0.515 rs4772099 chr13:99196121 A/C cg07423050 chr13:99094983 FARP1 -0.54 -9.79 -0.47 4.71e-20 Longevity; LUSC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg25072359 chr17:41440525 NA 0.65 9.27 0.45 2.3e-18 Menopause (age at onset); LUSC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg10295955 chr4:187884368 NA -1.03 -22.81 -0.78 4.31e-70 Lobe attachment (rater-scored or self-reported); LUSC cis rs11112613 0.818 rs73184093 chr12:106010066 G/C cg03607813 chr12:105948248 NA 0.73 8.43 0.42 1.07e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs17095355 0.901 rs6584964 chr10:111759160 G/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.35 -0.37 1.53e-12 Biliary atresia; LUSC cis rs9788682 0.895 rs3813570 chr15:78832832 T/C cg24631222 chr15:78858424 CHRNA5 0.83 11.41 0.53 1.09e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25203256 chr7:66205334 RABGEF1 -0.42 -6.11 -0.32 2.78e-9 Electrocardiographic conduction measures; LUSC cis rs11252926 0.501 rs2050971 chr10:525530 T/G cg18196295 chr10:418757 DIP2C -0.38 -6.16 -0.32 2.1e-9 Psychosis in Alzheimer's disease; LUSC trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg03929089 chr4:120376271 NA -0.6 -7.19 -0.37 4.38e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs1023500 0.507 rs6002600 chr22:42488906 G/A cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Schizophrenia; LUSC trans rs8073060 0.586 rs225286 chr17:33930458 G/A cg19694781 chr19:47549865 TMEM160 -1.15 -18.23 -0.71 5.05e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7107174 0.901 rs2511159 chr11:77974193 G/T cg02023728 chr11:77925099 USP35 -0.45 -6.84 -0.35 3.84e-11 Testicular germ cell tumor; LUSC trans rs1493916 1.000 rs9964702 chr18:31390427 A/C cg15819921 chr19:927150 ARID3A -0.44 -6.42 -0.33 4.77e-10 Life satisfaction; LUSC cis rs7681440 0.904 rs1822217 chr4:90765052 C/T cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs71403859 0.502 rs71403849 chr16:71484365 T/C cg08717414 chr16:71523259 ZNF19 -0.71 -8.44 -0.42 9.45e-16 Post bronchodilator FEV1; LUSC cis rs1595825 0.838 rs16826872 chr2:198898055 T/C cg10547527 chr2:198650123 BOLL -0.53 -6.28 -0.33 1.04e-9 Ulcerative colitis; LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg07507251 chr3:52567010 NT5DC2 0.33 6.37 0.33 6.25e-10 Bipolar disorder; LUSC cis rs9369695 0.842 rs2396825 chr6:47568696 A/G cg12968598 chr6:47444699 CD2AP 0.52 8.04 0.4 1.6e-14 Reticulocyte count; LUSC cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg02466173 chr16:30829666 NA -0.59 -11.12 -0.52 1.19e-24 Multiple myeloma; LUSC cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg13319975 chr6:146136371 FBXO30 0.5 7.44 0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.524 rs7932703 chr11:47769936 A/C cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs12971120 1.000 rs734559 chr18:72179579 G/A cg25817165 chr18:72167213 CNDP2 -0.71 -9.17 -0.45 4.93e-18 Refractive error; LUSC cis rs7202877 0.610 rs10871307 chr16:75335114 G/T cg03315344 chr16:75512273 CHST6 0.45 6.21 0.32 1.56e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9905704 0.846 rs372648 chr17:56736785 A/C cg12560992 chr17:57184187 TRIM37 0.58 8.36 0.42 1.75e-15 Testicular germ cell tumor; LUSC trans rs3857536 0.813 rs9360190 chr6:66942302 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.13 -0.32 2.43e-9 Blood trace element (Cu levels); LUSC cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.53 -0.38 4.93e-13 Personality dimensions; LUSC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg23630131 chr7:65973040 NA 0.2 5.66 0.3 3.25e-8 Aortic root size; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18404039 chr20:3184938 DDRGK1 -0.4 -5.99 -0.31 5.45e-9 Hepatitis; LUSC cis rs7091068 0.518 rs1409337 chr10:95439822 T/C cg20715218 chr10:95462985 C10orf4 0.51 6.46 0.33 3.63e-10 Urinary tract infection frequency; LUSC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.13 0.41 8.21e-15 Homoarginine levels; LUSC cis rs6733011 0.600 rs1568213 chr2:99432063 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.61 -0.34 1.51e-10 Bipolar disorder; LUSC cis rs4820539 1.000 rs4820539 chr22:23477970 C/T cg14186256 chr22:23484241 RTDR1 -0.9 -16.49 -0.67 4.05e-45 Bone mineral density; LUSC cis rs12900413 0.879 rs2165072 chr15:90302629 A/G cg24249390 chr15:90295951 MESP1 -0.48 -6.92 -0.35 2.25e-11 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg05025164 chr4:1340916 KIAA1530 0.46 7.07 0.36 9.08e-12 Obesity-related traits; LUSC cis rs977987 0.778 rs11858992 chr16:75411445 A/C cg03315344 chr16:75512273 CHST6 0.49 9.32 0.45 1.6e-18 Dupuytren's disease; LUSC cis rs6066835 1.000 rs4455220 chr20:47335017 A/G cg18078177 chr20:47281410 PREX1 0.7 5.91 0.31 8.34e-9 Multiple myeloma; LUSC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg16414030 chr3:133502952 NA -0.43 -6.76 -0.35 6.29e-11 Iron status biomarkers; LUSC cis rs9479482 0.967 rs11752529 chr6:150347971 C/T cg03788504 chr6:150331562 NA -0.26 -5.78 -0.3 1.76e-8 Alopecia areata; LUSC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs7568458 0.684 rs67988001 chr2:85787123 C/T cg02493740 chr2:85810744 VAMP5 -0.52 -9.05 -0.44 1.22e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4654899 0.897 rs7545133 chr1:21206143 T/G cg01072550 chr1:21505969 NA 0.49 7.41 0.38 1.07e-12 Superior frontal gyrus grey matter volume; LUSC cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.19 -0.41 5.51e-15 Axial length; LUSC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg25427524 chr10:38739819 LOC399744 -0.59 -10.63 -0.5 6.12e-23 Extrinsic epigenetic age acceleration; LUSC cis rs4654899 0.606 rs13376428 chr1:21120027 T/C cg01072550 chr1:21505969 NA -0.5 -7.32 -0.37 1.88e-12 Superior frontal gyrus grey matter volume; LUSC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.08 0.36 8.48e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs10089 0.951 rs1864923 chr5:127420843 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.89 12.55 0.57 7.02e-30 Ileal carcinoids; LUSC cis rs208520 0.874 rs208517 chr6:66947040 G/T cg07460842 chr6:66804631 NA -1.01 -14.32 -0.62 1.29e-36 Exhaled nitric oxide output; LUSC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Vitiligo; LUSC cis rs7202877 0.656 rs247427 chr16:75439132 T/C cg03315344 chr16:75512273 CHST6 -0.46 -6.3 -0.33 9.56e-10 Type 2 diabetes;Type 1 diabetes; LUSC cis rs8017423 0.967 rs12589808 chr14:90719236 C/T cg14092571 chr14:90743983 NA 0.37 6.07 0.32 3.39e-9 Mortality in heart failure; LUSC cis rs6582630 0.593 rs7134006 chr12:38596245 A/C cg13010199 chr12:38710504 ALG10B 0.64 9.79 0.47 4.45e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs10992471 0.651 rs10124058 chr9:95522882 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.42 -6.87 -0.35 3.2e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs4942242 0.663 rs7985489 chr13:44206148 T/C cg19169023 chr15:41853346 TYRO3 0.58 8.97 0.44 2.11e-17 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs939658 0.805 rs35462901 chr15:79442201 C/T cg17916960 chr15:79447300 NA -0.53 -10.55 -0.5 1.24e-22 Refractive error; LUSC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg06740227 chr12:86229804 RASSF9 0.44 6.96 0.36 1.77e-11 Major depressive disorder; LUSC cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg21132104 chr15:45694354 SPATA5L1 0.46 6.2 0.32 1.65e-9 Homoarginine levels; LUSC cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg11062466 chr8:58055876 NA 0.52 7.11 0.36 7.07e-12 Developmental language disorder (linguistic errors); LUSC cis rs2361718 0.631 rs4889989 chr17:78151860 C/G cg21238619 chr17:78079768 GAA 0.34 6.72 0.35 7.76e-11 Yeast infection; LUSC cis rs10791097 0.694 rs7107595 chr11:130758556 C/T cg12179176 chr11:130786555 SNX19 0.87 14.93 0.63 5.9e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9527 0.662 rs4919687 chr10:104595248 G/A cg15744005 chr10:104629667 AS3MT -0.32 -6.32 -0.33 8.44e-10 Arsenic metabolism; LUSC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg09904177 chr6:26538194 HMGN4 -0.5 -5.86 -0.31 1.08e-8 Intelligence (multi-trait analysis); LUSC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.37 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); LUSC cis rs2273669 0.667 rs11153150 chr6:109316652 C/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs1670533 1.000 rs62879260 chr4:1050850 T/C cg19318889 chr4:1322082 MAEA 0.43 5.73 0.3 2.28e-8 Recombination rate (females); LUSC cis rs4268898 0.662 rs2288074 chr2:24413595 C/T cg06627628 chr2:24431161 ITSN2 -0.87 -12.29 -0.56 7.01e-29 Asthma; LUSC cis rs5997397 1.000 rs5997397 chr22:29154455 A/G cg02153584 chr22:29168773 CCDC117 0.43 6.42 0.33 4.57e-10 Red cell distribution width; LUSC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg05368731 chr17:41323189 NBR1 -0.81 -13.47 -0.59 2.44e-33 Menopause (age at onset); LUSC trans rs2204008 0.837 rs11169157 chr12:37980047 T/C cg06521331 chr12:34319734 NA -0.42 -6.51 -0.34 2.69e-10 Bladder cancer; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg09192942 chr16:75682004 KARS;TERF2IP 0.47 5.97 0.31 6.01e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1595825 0.891 rs1440086 chr2:198906354 A/G cg00982548 chr2:198649783 BOLL -0.55 -6.98 -0.36 1.57e-11 Ulcerative colitis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06446895 chr17:79829189 ARHGDIA -0.45 -7.54 -0.38 4.45e-13 Electrocardiographic conduction measures; LUSC cis rs10744422 0.800 rs7138436 chr12:123223920 G/T cg25930673 chr12:123319894 HIP1R -0.62 -6.34 -0.33 7.48e-10 Schizophrenia; LUSC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg04025307 chr7:1156635 C7orf50 0.4 6.52 0.34 2.54e-10 Longevity;Endometriosis; LUSC cis rs13256369 0.802 rs35382339 chr8:8559255 G/A cg18904891 chr8:8559673 CLDN23 0.6 7.87 0.4 4.93e-14 Obesity-related traits; LUSC cis rs6942756 0.712 rs6467241 chr7:128997838 A/G cg02491457 chr7:128862824 NA -0.5 -7.3 -0.37 2.06e-12 White matter hyperintensity burden; LUSC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg00933542 chr6:150070202 PCMT1 0.33 6.85 0.35 3.51e-11 Lung cancer; LUSC cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg06784218 chr1:46089804 CCDC17 -0.58 -11.51 -0.53 4.82e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg13798912 chr7:905769 UNC84A -0.57 -5.88 -0.31 9.85e-9 Cerebrospinal P-tau181p levels; LUSC cis rs7914558 1.000 rs10883837 chr10:104896486 G/A cg05855489 chr10:104503620 C10orf26 0.6 9.67 0.47 1.11e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg19717773 chr7:2847554 GNA12 -0.35 -5.97 -0.31 5.99e-9 Height; LUSC cis rs8060686 0.920 rs73593810 chr16:67866783 C/T cg27539214 chr16:67997921 SLC12A4 -0.48 -6.15 -0.32 2.18e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs1864585 0.520 rs56109041 chr8:10657154 G/C cg26278703 chr11:58910052 FAM111A 0.53 6.0 0.31 5.2e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg11812906 chr14:75593930 NEK9 -0.64 -11.04 -0.52 2.28e-24 Height; LUSC cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg11062466 chr8:58055876 NA 0.46 6.21 0.32 1.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.38 0.37 1.26e-12 Bipolar disorder; LUSC cis rs2197308 0.655 rs1971964 chr12:37870474 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.9 0.51 7.3e-24 Morning vs. evening chronotype; LUSC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.82 13.28 0.59 1.28e-32 Hip circumference adjusted for BMI; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg16325326 chr1:53192061 ZYG11B 0.86 15.76 0.65 3.28e-42 Monocyte count; LUSC cis rs61990749 0.544 rs2544566 chr14:78181738 C/G cg02301378 chr14:78227641 SNW1;C14orf178 0.59 6.45 0.33 3.85e-10 Fibroblast growth factor basic levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13043177 chr5:169010744 CCDC99 0.76 6.09 0.32 3.05e-9 Cognitive performance; LUSC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg00074818 chr8:8560427 CLDN23 0.58 9.91 0.48 1.88e-20 Obesity-related traits; LUSC cis rs12594515 1.000 rs11854554 chr15:45994546 C/G cg06207120 chr15:45996521 NA 0.39 5.86 0.31 1.11e-8 Waist circumference;Weight; LUSC cis rs3806843 0.900 rs2563254 chr5:140142701 T/C cg26395211 chr5:140044315 WDR55 0.37 5.66 0.3 3.21e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.66 8.37 0.42 1.63e-15 Lung function (FEV1/FVC); LUSC cis rs4555082 1.000 rs7146012 chr14:105757566 G/A cg10792982 chr14:105748885 BRF1 0.46 8.17 0.41 6.54e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg08027265 chr7:2291960 NA -0.4 -6.52 -0.34 2.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs30380 0.632 rs27640 chr5:96127905 T/C cg16492584 chr5:96139282 ERAP1 -0.53 -7.23 -0.37 3.22e-12 Cerebrospinal fluid biomarker levels; LUSC cis rs6952809 0.532 rs6956223 chr7:2431331 T/C cg23289794 chr7:2394357 EIF3B -0.78 -10.28 -0.49 1.05e-21 Multiple sclerosis; LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg10862848 chr6:42927986 GNMT -0.29 -6.81 -0.35 4.44e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.81 0.43 6.77e-17 Axial length; LUSC cis rs16910800 1.000 rs1384473 chr11:23194943 T/C cg20040320 chr11:23191996 NA 0.44 6.52 0.34 2.64e-10 Cancer; LUSC cis rs2629540 0.766 rs10794177 chr10:126407409 G/C cg08799069 chr10:126477246 METTL10 0.6 8.23 0.41 4.3e-15 Cocaine dependence; LUSC cis rs701145 0.556 rs191651 chr3:153973887 T/G cg17054900 chr3:154042577 DHX36 0.44 5.68 0.3 2.86e-8 Coronary artery disease; LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg03354898 chr7:1950403 MAD1L1 -0.44 -8.79 -0.43 7.93e-17 Bipolar disorder and schizophrenia; LUSC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg27165867 chr14:105738592 BRF1 -0.51 -7.42 -0.38 9.52e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs4969178 0.965 rs16971105 chr17:76393975 G/T cg05887092 chr17:76393375 PGS1 0.52 9.37 0.46 1.13e-18 HDL cholesterol levels; LUSC cis rs7264396 0.887 rs2236161 chr20:34101631 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.61 -0.34 1.49e-10 Total cholesterol levels; LUSC cis rs77741769 0.529 rs10849791 chr12:121235280 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.42 0.42 1.14e-15 Mean corpuscular volume; LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.05 -0.31 3.99e-9 Developmental language disorder (linguistic errors); LUSC cis rs7119167 0.686 rs7342205 chr11:73044351 A/G cg17517138 chr11:73019481 ARHGEF17 0.49 5.68 0.3 2.88e-8 Blood protein levels; LUSC cis rs854765 0.551 rs56886154 chr17:17831473 C/A cg09796270 chr17:17721594 SREBF1 0.42 7.52 0.38 5.22e-13 Total body bone mineral density; LUSC cis rs35146811 0.538 rs3823642 chr7:99796072 T/C cg19116668 chr7:99932089 PMS2L1 -0.33 -5.67 -0.3 3.17e-8 Coronary artery disease; LUSC trans rs6502050 0.871 rs6502051 chr17:80059332 A/C cg07393940 chr7:158741817 NA -0.36 -6.32 -0.33 8.31e-10 Life satisfaction; LUSC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.32e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2857891 0.659 rs2262676 chr11:6996609 T/G cg14883916 chr11:6947541 ZNF215 0.44 5.83 0.3 1.34e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg08807101 chr21:30365312 RNF160 0.75 13.45 0.59 2.92e-33 Dental caries; LUSC cis rs7615316 0.872 rs6414350 chr3:142316660 C/G cg16271453 chr3:142027066 XRN1 -0.36 -6.03 -0.31 4.41e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg02574844 chr11:5959923 NA -0.4 -6.03 -0.31 4.45e-9 DNA methylation (variation); LUSC cis rs12210905 1.000 rs3999221 chr6:26959322 C/G cg23155468 chr6:27110703 HIST1H2BK -0.69 -6.03 -0.31 4.45e-9 Hip circumference adjusted for BMI; LUSC cis rs7572644 0.665 rs4233716 chr2:28034384 C/T cg27432699 chr2:27873401 GPN1 0.61 7.86 0.4 5.21e-14 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg00631329 chr6:26305371 NA -0.48 -9.41 -0.46 8.53e-19 Educational attainment; LUSC cis rs2302729 0.625 rs1592573 chr12:2831556 A/T cg19945202 chr12:2788847 CACNA1C -0.37 -5.66 -0.3 3.28e-8 Sleep quality; LUSC cis rs1691799 0.899 rs1168314 chr12:66746937 A/G cg16791601 chr12:66731901 HELB -0.71 -12.52 -0.57 9.7e-30 White blood cell count (basophil); LUSC cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.5 -0.46 4.07e-19 Schizophrenia; LUSC cis rs2976388 0.967 rs2585183 chr8:143766059 C/G cg17252645 chr8:143867129 LY6D -0.38 -6.44 -0.33 4.14e-10 Urinary tract infection frequency; LUSC cis rs17540621 1.000 rs79390512 chr2:47199046 A/G cg23978866 chr2:47230407 TTC7A -0.92 -6.91 -0.35 2.44e-11 Response to statin therapy; LUSC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg21285383 chr16:89894308 SPIRE2 0.31 6.58 0.34 1.79e-10 Vitiligo; LUSC cis rs977987 0.778 rs34222958 chr16:75398252 C/T cg03315344 chr16:75512273 CHST6 0.48 9.19 0.45 4.25e-18 Dupuytren's disease; LUSC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg06028605 chr16:24865363 SLC5A11 0.37 6.0 0.31 5.1e-9 Intelligence (multi-trait analysis); LUSC cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg24692254 chr21:30365293 RNF160 -0.82 -15.1 -0.64 1.19e-39 Dental caries; LUSC cis rs4144743 0.941 rs10438782 chr17:45323892 G/A cg18085866 chr17:45331354 ITGB3 -0.7 -7.62 -0.38 2.61e-13 Body mass index; LUSC cis rs7666738 0.546 rs13149516 chr4:98913030 T/A cg05340658 chr4:99064831 C4orf37 0.57 8.81 0.43 7.13e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs7177699 0.557 rs6495335 chr15:79117133 G/T cg15571903 chr15:79123663 NA 0.32 5.9 0.31 9.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2295359 1.000 rs11209007 chr1:67619345 C/G cg12940439 chr1:67600707 NA 0.35 6.12 0.32 2.56e-9 Psoriasis; LUSC cis rs1003719 0.641 rs13046844 chr21:38517603 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.39 -0.49 4.21e-22 Eye color traits; LUSC cis rs854765 0.623 rs9893690 chr17:17753846 A/T cg04398451 chr17:18023971 MYO15A 0.43 6.86 0.35 3.37e-11 Total body bone mineral density; LUSC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg24531977 chr5:56204891 C5orf35 0.74 12.03 0.55 6.27e-28 Initial pursuit acceleration; LUSC cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg08999081 chr20:33150536 PIGU -0.41 -7.68 -0.39 1.79e-13 Glomerular filtration rate (creatinine); LUSC cis rs1670533 1.000 rs2045069 chr4:1052206 T/C cg19318889 chr4:1322082 MAEA 0.43 5.7 0.3 2.66e-8 Recombination rate (females); LUSC cis rs7523273 0.606 rs12401619 chr1:207976276 G/C cg22525895 chr1:207977042 MIR29B2 -0.38 -6.05 -0.31 3.98e-9 Schizophrenia; LUSC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11890956 chr21:40555474 PSMG1 -0.87 -15.51 -0.65 3.18e-41 Cognitive function; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18839017 chr6:53660548 LRRC1 0.39 6.02 0.31 4.49e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11971779 0.680 rs4728465 chr7:139069061 G/A cg07862535 chr7:139043722 LUC7L2 0.59 7.37 0.37 1.32e-12 Diisocyanate-induced asthma; LUSC cis rs12579753 1.000 rs7956826 chr12:82173365 A/G cg07988820 chr12:82153109 PPFIA2 -0.46 -6.47 -0.33 3.55e-10 Resting heart rate; LUSC trans rs1347297 0.526 rs6757186 chr2:179259719 G/C cg14011486 chr1:26737247 LIN28 0.42 6.68 0.34 9.76e-11 Alzheimer disease and age of onset; LUSC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9902453 0.904 rs7219456 chr17:28374112 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.53 -0.5 1.46e-22 Coffee consumption (cups per day); LUSC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg24399712 chr22:39784796 NA -0.65 -12.13 -0.55 2.6e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9287719 0.967 rs6432119 chr2:10753687 A/T cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg18357526 chr6:26021779 HIST1H4A 0.45 7.15 0.36 5.47e-12 Intelligence (multi-trait analysis); LUSC cis rs9303542 0.527 rs62066689 chr17:46609092 T/C cg09704116 chr17:46666958 LOC404266 -0.37 -6.52 -0.34 2.56e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs4363385 0.747 rs1415962 chr1:152958731 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.69 -0.39 1.63e-13 Inflammatory skin disease; LUSC cis rs951366 0.576 rs11240561 chr1:205712957 T/G cg24503407 chr1:205819492 PM20D1 -0.48 -6.38 -0.33 6.01e-10 Menarche (age at onset); LUSC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg02269571 chr22:50332266 NA -0.67 -9.73 -0.47 7.13e-20 Schizophrenia; LUSC cis rs208520 0.690 rs2797693 chr6:66868985 T/C cg07460842 chr6:66804631 NA -1.13 -17.85 -0.7 1.6e-50 Exhaled nitric oxide output; LUSC cis rs3749237 0.964 rs7431078 chr3:49808190 G/A cg03060546 chr3:49711283 APEH 0.59 8.21 0.41 4.93e-15 Resting heart rate; LUSC cis rs6696846 0.765 rs11240360 chr1:205083865 T/C cg03948781 chr1:205179583 DSTYK 0.33 6.31 0.33 8.67e-10 Red blood cell count; LUSC cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg09184832 chr6:79620586 NA -0.45 -7.29 -0.37 2.27e-12 Intelligence (multi-trait analysis); LUSC cis rs12410462 0.681 rs4486420 chr1:227572321 T/A cg23173402 chr1:227635558 NA 0.56 6.28 0.32 1.07e-9 Major depressive disorder; LUSC cis rs2227564 0.649 rs2948689 chr10:75657860 A/G cg23231163 chr10:75533350 FUT11 -0.43 -6.05 -0.31 3.95e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg06064525 chr11:970664 AP2A2 -0.36 -7.17 -0.37 4.88e-12 Alzheimer's disease (late onset); LUSC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg20406979 chr6:167373233 NA 0.26 6.11 0.32 2.77e-9 Crohn's disease; LUSC trans rs4729127 1.000 rs17166229 chr7:94017673 A/G cg20086523 chr13:52378287 DHRS12 0.59 6.58 0.34 1.78e-10 Intelligence; LUSC cis rs367615 0.660 rs10061221 chr5:108839038 C/T cg17395555 chr5:108820864 NA 0.63 11.37 0.53 1.5e-25 Colorectal cancer (SNP x SNP interaction); LUSC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11890956 chr21:40555474 PSMG1 -0.87 -15.41 -0.64 7.3400000000000005e-41 Cognitive function; LUSC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC cis rs854765 0.505 rs4506969 chr17:17899839 A/G cg16928487 chr17:17741425 SREBF1 -0.36 -6.75 -0.35 6.65e-11 Total body bone mineral density; LUSC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.73 -0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs6087990 0.806 rs910085 chr20:31383353 T/G cg13636640 chr20:31349939 DNMT3B 0.92 19.26 0.73 3.84e-56 Ulcerative colitis; LUSC cis rs7615952 1.000 rs9289275 chr3:125648659 A/T cg02807482 chr3:125708958 NA -0.48 -5.65 -0.3 3.4e-8 Blood pressure (smoking interaction); LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg11843238 chr5:131593191 PDLIM4 0.39 6.62 0.34 1.46e-10 Breast cancer; LUSC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg19592336 chr6:28129416 ZNF389 0.5 6.51 0.34 2.74e-10 Depression; LUSC cis rs208515 0.525 rs10944870 chr6:66687757 G/C cg07460842 chr6:66804631 NA 1.06 14.5 0.62 2.72e-37 Exhaled nitric oxide levels; LUSC trans rs9329221 0.698 rs12547997 chr8:10260837 A/G cg06636001 chr8:8085503 FLJ10661 0.51 7.01 0.36 1.29e-11 Neuroticism; LUSC cis rs3812049 0.784 rs2250127 chr5:127388844 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.69 -8.91 -0.44 3.39e-17 Lymphocyte counts;Red cell distribution width; LUSC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg06634786 chr22:41940651 POLR3H 0.51 6.11 0.32 2.82e-9 Vitiligo; LUSC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg16606324 chr3:10149918 C3orf24 0.43 6.63 0.34 1.37e-10 Alzheimer's disease; LUSC cis rs1847202 1.000 rs11918615 chr3:72942407 T/C cg25664220 chr3:72788482 NA -0.35 -6.43 -0.33 4.54e-10 Motion sickness; LUSC trans rs2204008 0.837 rs55962152 chr12:38234281 G/A cg06521331 chr12:34319734 NA -0.4 -6.14 -0.32 2.38e-9 Bladder cancer; LUSC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg17173187 chr15:85201210 NMB 0.37 6.52 0.34 2.57e-10 Schizophrenia; LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.71 -0.39 1.46e-13 Lymphocyte counts; LUSC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -6.82 -0.35 4.29e-11 Total body bone mineral density; LUSC cis rs9309473 1.000 rs7598419 chr2:73798223 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.24 -0.37 3.19e-12 Metabolite levels; LUSC cis rs10876993 0.890 rs799575 chr12:58069107 A/G cg15848620 chr12:58087721 OS9 -0.55 -7.92 -0.4 3.5e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg04727924 chr7:799746 HEATR2 -0.56 -6.77 -0.35 5.88e-11 Cerebrospinal P-tau181p levels; LUSC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11644478 chr21:40555479 PSMG1 0.82 14.8 0.63 1.83e-38 Cognitive function; LUSC cis rs1451375 0.617 rs2329371 chr7:50615440 G/A cg18232548 chr7:50535776 DDC 0.51 6.89 0.35 2.77e-11 Malaria; LUSC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg08888203 chr3:10149979 C3orf24 0.64 9.15 0.45 5.82e-18 Alzheimer's disease; LUSC trans rs6445525 0.875 rs7636595 chr3:65992843 A/T cg04367164 chr11:76902992 MYO7A 0.31 6.39 0.33 5.6e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg02428538 chr16:24856791 SLC5A11 -0.58 -6.35 -0.33 6.9e-10 Intelligence (multi-trait analysis); LUSC cis rs4243830 0.850 rs4434862 chr1:6602241 C/A cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.13 -0.32 2.55e-9 Body mass index; LUSC cis rs7312933 0.558 rs7965743 chr12:42736822 A/G cg01256987 chr12:42539512 GXYLT1 0.34 6.21 0.32 1.57e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg06505273 chr16:24850292 NA 0.41 5.75 0.3 2e-8 Intelligence (multi-trait analysis); LUSC cis rs2050392 1.000 rs2265186 chr10:30691743 C/T cg18806716 chr10:30721971 MAP3K8 0.45 7.22 0.37 3.55e-12 Inflammatory bowel disease; LUSC cis rs9788682 1.000 rs12438181 chr15:78812098 G/A cg24631222 chr15:78858424 CHRNA5 0.82 11.29 0.53 2.9e-25 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs12310956 0.532 rs35366144 chr12:33992000 C/G cg13010199 chr12:38710504 ALG10B 0.56 8.42 0.42 1.12e-15 Morning vs. evening chronotype; LUSC cis rs7267979 0.816 rs6076358 chr20:25519403 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.77 -15.89 -0.66 9.82e-43 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg12463550 chr7:65579703 CRCP 0.56 8.46 0.42 8.66e-16 Aortic root size; LUSC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.43 -6.3 -0.33 9.45e-10 Height; LUSC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.64 6.49 0.33 3.14e-10 Initial pursuit acceleration; LUSC cis rs1941023 0.503 rs7944025 chr11:60142538 C/A cg08716584 chr11:60157161 MS4A7 -0.65 -12.39 -0.56 2.92e-29 Congenital heart disease (maternal effect); LUSC cis rs11122272 0.735 rs2808585 chr1:231514218 C/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs2120019 1.000 rs2120019 chr15:75334184 T/C cg17294928 chr15:75287854 SCAMP5 -0.92 -13.07 -0.58 8.12e-32 Blood trace element (Zn levels); LUSC cis rs10191773 0.589 rs72831634 chr2:112946796 A/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.73 7.62 0.38 2.65e-13 Yeast infection; LUSC cis rs7949030 0.964 rs2957122 chr11:62392100 G/C cg22862634 chr11:62369728 EML3;MTA2 -0.5 -8.14 -0.41 8.12e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2239547 0.522 rs2581815 chr3:52982159 C/G cg11645453 chr3:52864694 ITIH4 0.48 11.09 0.52 1.51e-24 Schizophrenia; LUSC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg12927641 chr6:109611667 NA -0.34 -5.8 -0.3 1.53e-8 Reticulocyte fraction of red cells; LUSC cis rs7208859 0.623 rs9914499 chr17:29107588 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs950027 0.620 rs2467862 chr15:45643843 T/G cg21132104 chr15:45694354 SPATA5L1 0.42 6.13 0.32 2.49e-9 Response to fenofibrate (adiponectin levels); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg10380709 chr20:61558067 DIDO1 -0.45 -5.99 -0.31 5.36e-9 Hepatitis; LUSC trans rs7618501 0.669 rs7634084 chr3:49949834 A/T cg21659725 chr3:3221576 CRBN 0.64 10.62 0.5 6.82e-23 Intelligence (multi-trait analysis); LUSC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.65 -0.39 2.18e-13 Personality dimensions; LUSC cis rs7267979 1.000 rs6050602 chr20:25401203 A/G cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3930017 1.000 rs7783809 chr7:76719551 G/A cg15770687 chr7:76625569 PMS2L11 0.43 6.09 0.32 3.08e-9 Body mass index; LUSC cis rs67311347 0.605 rs1880762 chr3:40283215 A/G cg09455208 chr3:40491958 NA 0.48 7.9 0.4 4e-14 Renal cell carcinoma; LUSC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.51 0.38 5.61e-13 Prudent dietary pattern; LUSC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg23583168 chr7:148888333 NA -0.83 -14.41 -0.62 6.07e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7208859 0.623 rs9911784 chr17:29124580 A/C cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs10754283 0.967 rs1317864 chr1:90105448 A/G cg21401794 chr1:90099060 LRRC8C 0.65 9.8 0.47 4.22e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg17261708 chr5:176794207 RGS14 -0.36 -6.33 -0.33 7.83e-10 Hemoglobin concentration;Hematocrit; LUSC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg11764359 chr7:65958608 NA 0.62 9.38 0.46 1e-18 Aortic root size; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06444730 chr1:84544284 PRKACB -0.42 -6.3 -0.33 9.25e-10 Triglycerides; LUSC cis rs7727544 0.716 rs6863213 chr5:131575932 C/T cg04518342 chr5:131593106 PDLIM4 0.33 6.04 0.31 4.1e-9 Blood metabolite levels; LUSC cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg09184832 chr6:79620586 NA -0.45 -7.35 -0.37 1.57e-12 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.59 0.78 3.14e-69 Prudent dietary pattern; LUSC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg07424592 chr7:64974309 NA -0.64 -5.79 -0.3 1.61e-8 Diabetic kidney disease; LUSC cis rs34779708 0.931 rs11593858 chr10:35381373 G/A cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs427941 0.655 rs201472 chr7:101744428 C/T cg06246474 chr7:101738831 CUX1 0.39 6.38 0.33 5.9e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg05340658 chr4:99064831 C4orf37 0.57 9.51 0.46 3.93e-19 Colonoscopy-negative controls vs population controls; LUSC trans rs561341 1.000 rs693116 chr17:30246124 C/T cg20587970 chr11:113659929 NA -1.28 -17.42 -0.69 8.23e-49 Hip circumference adjusted for BMI; LUSC cis rs240764 0.578 rs9498252 chr6:101194481 A/G cg09795085 chr6:101329169 ASCC3 0.43 6.13 0.32 2.49e-9 Neuroticism; LUSC cis rs2274273 0.868 rs9919926 chr14:55813890 G/C cg04306507 chr14:55594613 LGALS3 0.53 11.49 0.53 5.65e-26 Protein biomarker; LUSC cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg23649088 chr2:200775458 C2orf69 0.56 7.51 0.38 5.51e-13 Schizophrenia; LUSC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg04865166 chr7:105162814 PUS7 0.52 5.71 0.3 2.5e-8 Bipolar disorder (body mass index interaction); LUSC trans rs1005277 0.579 rs2474586 chr10:38418882 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.65 -0.47 1.39e-19 Extrinsic epigenetic age acceleration; LUSC cis rs7216064 0.684 rs8182243 chr17:66018505 T/C cg12091567 chr17:66097778 LOC651250 0.88 14.09 0.61 9.98e-36 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21659725 chr3:3221576 CRBN -0.58 -8.22 -0.41 4.41e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg15117754 chr3:10150083 C3orf24 0.46 6.14 0.32 2.3e-9 Alzheimer's disease; LUSC cis rs7113850 0.541 rs4367945 chr11:24215605 A/C ch.11.24196551F chr11:24239977 NA 1.01 8.37 0.42 1.59e-15 Bone fracture in osteoporosis; LUSC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.55 -5.9 -0.31 8.81e-9 Glomerular filtration rate in chronic kidney disease; LUSC cis rs11583043 0.708 rs1335745 chr1:101546439 T/A cg11406453 chr1:101602562 NA -0.4 -6.75 -0.35 6.61e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9467773 0.935 rs4573 chr6:26546808 A/G cg11502198 chr6:26597334 ABT1 0.53 7.9 0.4 4.21e-14 Intelligence (multi-trait analysis); LUSC cis rs75920871 0.588 rs6589587 chr11:116875338 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.7 -0.34 8.86e-11 Subjective well-being; LUSC cis rs11229555 0.645 rs11229429 chr11:58180872 G/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs7824557 0.650 rs2572406 chr8:11092252 C/G cg15556689 chr8:8085844 FLJ10661 0.45 7.07 0.36 9.21e-12 Retinal vascular caliber; LUSC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg26769984 chr7:1090371 C7orf50 0.61 8.49 0.42 6.93e-16 Bronchopulmonary dysplasia; LUSC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg18876405 chr7:65276391 NA -0.69 -12.38 -0.56 3.09e-29 Aortic root size; LUSC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg20295408 chr7:1910781 MAD1L1 -0.46 -6.47 -0.33 3.39e-10 Schizophrenia; LUSC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg24060327 chr5:131705240 SLC22A5 -0.53 -8.8 -0.43 7.57e-17 Breast cancer; LUSC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg19717773 chr7:2847554 GNA12 -0.38 -5.96 -0.31 6.56e-9 Height; LUSC cis rs8072100 1.000 rs7210738 chr17:45757598 G/A cg08085267 chr17:45401833 C17orf57 0.6 10.0 0.48 9.4e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs782590 0.967 rs35504023 chr2:55806503 C/T cg03859395 chr2:55845619 SMEK2 -0.84 -15.31 -0.64 1.83e-40 Metabolic syndrome; LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.82 -0.35 4.27e-11 Menopause (age at onset); LUSC cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs9303401 0.659 rs7210432 chr17:56668170 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC cis rs7772486 0.902 rs1331643 chr6:146398873 T/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.96 -0.36 1.83e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs427394 0.664 rs274696 chr5:6732213 A/C cg10857441 chr5:6722123 POLS -0.44 -8.67 -0.43 1.88e-16 Menopause (age at onset); LUSC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg18230493 chr5:56204884 C5orf35 -0.93 -13.72 -0.6 2.66e-34 Initial pursuit acceleration; LUSC cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg08807101 chr21:30365312 RNF160 -0.8 -15.66 -0.65 7.56e-42 Dental caries; LUSC cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg25817165 chr18:72167213 CNDP2 -0.75 -11.17 -0.52 8.07e-25 Refractive error; LUSC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg02167203 chr6:41068553 NFYA;LOC221442 -0.4 -5.8 -0.3 1.53e-8 Alzheimer's disease (late onset); LUSC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg06145435 chr7:1022769 CYP2W1 0.34 5.78 0.3 1.74e-8 Bronchopulmonary dysplasia; LUSC cis rs61612642 0.537 rs6915565 chr6:42192582 G/A cg10382835 chr6:42185730 MRPS10 0.65 6.44 0.33 4.12e-10 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg03433033 chr1:76189801 ACADM 0.79 12.23 0.56 1.17e-28 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 0.549 rs11698185 chr20:25181998 T/C cg08601574 chr20:25228251 PYGB 0.44 6.73 0.35 7.59e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1003719 0.751 rs10154032 chr21:38453459 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.41 0.53 1.1e-25 Eye color traits; LUSC cis rs9287719 0.774 rs4997811 chr2:10755538 T/C cg00105475 chr2:10696890 NA 0.36 5.81 0.3 1.42e-8 Prostate cancer; LUSC cis rs954108 0.809 rs1592060 chr13:29368944 T/C cg11788234 chr13:29393811 NA -0.38 -6.68 -0.34 1.01e-10 Obesity-related traits; LUSC cis rs151234 0.800 rs231972 chr16:28538336 A/C cg01378222 chr16:28622494 SULT1A1 -0.61 -7.86 -0.4 5.37e-14 Platelet distribution width; LUSC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg00132208 chr4:10120780 NA 0.35 5.82 0.3 1.38e-8 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7647973 0.667 rs9869256 chr3:49624095 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.7 -7.45 -0.38 8.27e-13 Menarche (age at onset); LUSC cis rs854765 0.533 rs2955354 chr17:17948716 G/C cg04398451 chr17:18023971 MYO15A 0.57 9.53 0.46 3.41e-19 Total body bone mineral density; LUSC cis rs892961 0.932 rs747481 chr17:75412143 A/G cg05865280 chr17:75406074 SEPT9 0.45 9.5 0.46 4.27e-19 Airflow obstruction; LUSC cis rs377070 0.934 rs309407 chr4:123619335 T/C cg10495464 chr4:123653540 BBS12;LOC729338 0.49 7.14 0.36 5.8e-12 Mosquito bite size; LUSC trans rs11700980 0.551 rs2832024 chr21:30113692 C/A cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg06850241 chr22:41845214 NA -0.31 -5.89 -0.31 9.41e-9 Vitiligo; LUSC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg21951975 chr1:209979733 IRF6 -0.55 -6.86 -0.35 3.42e-11 Coronary artery disease; LUSC cis rs2236918 0.932 rs2488471 chr1:242019831 T/C cg17736920 chr1:242011382 EXO1 0.46 7.25 0.37 2.92e-12 Menopause (age at onset); LUSC trans rs7726839 0.540 rs72703083 chr5:595365 C/T cg25482853 chr8:67687455 SGK3 1.12 16.14 0.66 1.01e-43 Obesity-related traits; LUSC cis rs7267979 0.966 rs8123949 chr20:25388133 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.57 -0.34 1.93e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg04450456 chr4:17643702 FAM184B 0.39 6.67 0.34 1.09e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg20891283 chr12:69753455 YEATS4 0.64 10.2 0.49 1.97e-21 Blood protein levels; LUSC cis rs9467773 0.804 rs2073526 chr6:26374658 C/T cg09904177 chr6:26538194 HMGN4 -0.51 -8.05 -0.4 1.47e-14 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg06064525 chr11:970664 AP2A2 0.48 10.53 0.5 1.42e-22 Alzheimer's disease (late onset); LUSC trans rs214467 0.579 rs214470 chr7:110865216 A/G cg04404789 chr16:46722505 ORC6L;VPS35 0.35 6.03 0.31 4.35e-9 Schizophrenia; LUSC cis rs713477 0.967 rs34652660 chr14:55919480 C/A cg04306507 chr14:55594613 LGALS3 -0.33 -6.42 -0.33 4.73e-10 Pediatric bone mineral content (femoral neck); LUSC trans rs61931739 0.534 rs11053075 chr12:34207009 A/G cg13010199 chr12:38710504 ALG10B -0.55 -8.56 -0.42 4.24e-16 Morning vs. evening chronotype; LUSC trans rs2262909 0.924 rs11085509 chr19:22204573 T/C cg05197062 chr11:11642011 GALNTL4 -0.51 -7.08 -0.36 8.34e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs11702148 0.552 rs6517178 chr21:34888621 C/T cg14850771 chr21:34775459 IFNGR2 -0.4 -5.86 -0.31 1.1e-8 Mean corpuscular hemoglobin; LUSC cis rs6669072 1.000 rs10922924 chr1:91252863 A/G cg08895590 chr1:91227319 NA 0.34 7.7 0.39 1.5700000000000001e-13 Cognitive function; LUSC cis rs4727027 0.704 rs1123992 chr7:148907201 C/G cg23583168 chr7:148888333 NA -0.79 -13.03 -0.58 1.17e-31 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs2898290 0.622 rs7822109 chr8:11349147 T/C cg08975724 chr8:8085496 FLJ10661 -0.41 -6.08 -0.32 3.23e-9 Systolic blood pressure; LUSC cis rs4629710 0.592 rs9492868 chr6:131542238 A/C cg12700074 chr6:131571435 AKAP7 -0.36 -6.1 -0.32 2.88e-9 Multiple myeloma (IgH translocation); LUSC cis rs2404602 0.608 rs12911035 chr15:76606591 T/C cg00316803 chr15:76480434 C15orf27 -0.4 -6.78 -0.35 5.32e-11 Blood metabolite levels; LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg11645453 chr3:52864694 ITIH4 0.34 7.7 0.39 1.59e-13 Bipolar disorder; LUSC cis rs7944584 0.563 rs61895112 chr11:47560433 T/C cg20307385 chr11:47447363 PSMC3 0.85 12.12 0.55 2.82e-28 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs7940866 0.838 rs1991898 chr11:130801786 C/G cg12179176 chr11:130786555 SNX19 -0.67 -10.54 -0.5 1.26e-22 Schizophrenia; LUSC cis rs6542838 0.641 rs4850890 chr2:99535426 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.58 -0.34 1.82e-10 Fear of minor pain; LUSC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg10523679 chr1:76189770 ACADM 0.85 11.37 0.53 1.49e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg00071950 chr4:10020882 SLC2A9 0.64 11.0 0.52 3.11e-24 Bone mineral density; LUSC cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.58 -8.65 -0.43 2.27e-16 Colorectal cancer; LUSC cis rs983392 0.836 rs12453 chr11:59945745 T/C cg24026212 chr11:59952134 MS4A6A -0.37 -6.35 -0.33 7.09e-10 Alzheimer's disease (late onset); LUSC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.39 0.59 5.16e-33 Platelet count; LUSC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg02770061 chr7:158046166 PTPRN2 0.33 5.72 0.3 2.31e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg03609598 chr5:56110824 MAP3K1 -0.44 -6.14 -0.32 2.31e-9 Initial pursuit acceleration; LUSC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.77 0.35 5.7e-11 Tonsillectomy; LUSC cis rs6456156 0.792 rs10946212 chr6:167515947 C/G cg07741184 chr6:167504864 NA 0.37 6.48 0.33 3.33e-10 Primary biliary cholangitis; LUSC cis rs7582180 0.629 rs11685406 chr2:100946638 A/G cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg25036284 chr2:26402008 FAM59B 0.77 11.11 0.52 1.29e-24 Gut microbiome composition (summer); LUSC cis rs9309473 0.500 rs2421668 chr2:73885096 G/A cg20560298 chr2:73613845 ALMS1 0.47 7.23 0.37 3.33e-12 Metabolite levels; LUSC cis rs9916302 0.706 rs801427 chr17:37436711 A/G cg07936489 chr17:37558343 FBXL20 -0.78 -9.97 -0.48 1.17e-20 Glomerular filtration rate (creatinine); LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg20821713 chr7:1055600 C7orf50 -0.39 -5.95 -0.31 6.59e-9 Longevity;Endometriosis; LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg12564285 chr5:131593104 PDLIM4 0.45 8.05 0.4 1.43e-14 Breast cancer; LUSC cis rs10751667 0.643 rs6597969 chr11:928843 C/T ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.64e-9 Alzheimer's disease (late onset); LUSC cis rs9300255 0.568 rs1621194 chr12:123651018 T/C cg00376283 chr12:123451042 ABCB9 0.67 8.42 0.42 1.1e-15 Neutrophil percentage of white cells; LUSC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg25036284 chr2:26402008 FAM59B 0.67 8.92 0.44 3.14e-17 Gut microbiome composition (summer); LUSC cis rs3862030 0.720 rs3740414 chr10:104232809 T/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -8.97 -0.44 2.15e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC trans rs9329221 0.537 rs13254175 chr8:9978772 C/T cg15556689 chr8:8085844 FLJ10661 0.52 7.75 0.39 1.14e-13 Neuroticism; LUSC cis rs6062509 0.895 rs55946717 chr20:62363869 G/A cg21849932 chr20:62369462 LIME1 -0.4 -5.91 -0.31 8.37e-9 Prostate cancer; LUSC cis rs4919687 0.679 rs12762176 chr10:104499232 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -6.07 -0.32 3.52e-9 Colorectal cancer; LUSC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg22782873 chr19:19639568 YJEFN3 0.53 6.51 0.34 2.82e-10 Bipolar disorder; LUSC cis rs9462846 0.691 rs9462853 chr6:42910666 T/C cg02353165 chr6:42928485 GNMT 0.48 6.61 0.34 1.57e-10 Blood protein levels; LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg27094323 chr7:1216898 NA -0.32 -5.65 -0.3 3.36e-8 Longevity;Endometriosis; LUSC trans rs11098499 0.604 rs17051352 chr4:120581427 G/A cg25214090 chr10:38739885 LOC399744 0.51 7.25 0.37 2.97e-12 Corneal astigmatism; LUSC cis rs17125944 0.505 rs75296244 chr14:53233218 G/A cg00686598 chr14:53173677 PSMC6 1.15 10.47 0.5 2.35e-22 Alzheimer's disease (late onset); LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.35 5.85 0.3 1.19e-8 Menopause (age at onset); LUSC cis rs7945705 0.846 rs905290 chr11:8753729 A/G cg12365402 chr11:9010492 NRIP3 0.44 7.6 0.38 3.08e-13 Hemoglobin concentration; LUSC trans rs7824557 0.767 rs3808513 chr8:11157460 G/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.39 -0.33 5.73e-10 Retinal vascular caliber; LUSC cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg24130564 chr14:104152367 KLC1 -0.67 -10.64 -0.5 6.05e-23 Intelligence (multi-trait analysis); LUSC cis rs72949976 0.934 rs13406406 chr2:214034826 C/T cg08319019 chr2:214017104 IKZF2 -0.62 -9.61 -0.47 1.85e-19 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs4654899 1.000 rs12126133 chr1:21456537 T/C cg01072550 chr1:21505969 NA -0.55 -8.4 -0.42 1.32e-15 Superior frontal gyrus grey matter volume; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg03395511 chr6:291903 DUSP22 -0.5 -7.57 -0.38 3.6e-13 Menopause (age at onset); LUSC cis rs9473147 0.543 rs9349417 chr6:47580657 A/G cg02130027 chr6:47444894 CD2AP 0.36 5.76 0.3 1.86e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7953508 0.506 rs3869308 chr12:93959918 A/G cg18151635 chr12:93972918 NA -0.6 -8.67 -0.43 1.94e-16 Pubertal anthropometrics; LUSC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg24838063 chr12:130822603 PIWIL1 0.7 10.79 0.51 1.7e-23 Menopause (age at onset); LUSC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg00701064 chr4:6280414 WFS1 0.6 15.05 0.64 1.98e-39 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs17826219 0.500 rs2449749 chr17:29078298 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.8e-12 Body mass index; LUSC cis rs10189230 1.000 rs10189230 chr2:222357961 T/A cg14652038 chr2:222343519 EPHA4 0.33 5.77 0.3 1.83e-8 Urate levels in lean individuals; LUSC cis rs9811920 0.695 rs793497 chr3:99505610 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -7.29 -0.37 2.27e-12 Axial length; LUSC cis rs7180079 0.541 rs72756953 chr15:64537101 C/A cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Monocyte count; LUSC cis rs9640161 0.617 rs56019796 chr7:150009226 T/C cg10018233 chr7:150070692 REPIN1 0.33 6.11 0.32 2.72e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs6951245 1.000 rs79327308 chr7:1108141 A/C cg13565492 chr6:43139072 SRF -0.62 -6.56 -0.34 2.09e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg21782813 chr7:2030301 MAD1L1 0.52 8.65 0.43 2.13e-16 Bipolar disorder and schizophrenia; LUSC cis rs2404602 0.669 rs8036703 chr15:76951040 A/G cg23625390 chr15:77176239 SCAPER 0.47 7.22 0.37 3.55e-12 Blood metabolite levels; LUSC cis rs6565180 0.962 rs11642676 chr16:30371655 C/G cg17640201 chr16:30407289 ZNF48 -0.86 -14.17 -0.61 4.92e-36 Tonsillectomy; LUSC cis rs1595825 0.891 rs16824631 chr2:198708695 T/G cg10547527 chr2:198650123 BOLL -0.5 -5.93 -0.31 7.77e-9 Ulcerative colitis; LUSC cis rs3808502 0.549 rs7831039 chr8:11427637 A/T cg27411982 chr8:10470053 RP1L1 -0.47 -7.33 -0.37 1.79e-12 Neuroticism; LUSC cis rs9916302 0.605 rs12938099 chr17:37612910 T/G cg07936489 chr17:37558343 FBXL20 -0.82 -9.8 -0.47 4.36e-20 Glomerular filtration rate (creatinine); LUSC cis rs1451375 0.785 rs6593010 chr7:50629888 A/G cg18232548 chr7:50535776 DDC 0.53 8.21 0.41 5.02e-15 Malaria; LUSC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.72e-12 Blood metabolite levels; LUSC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.95 18.1 0.7 1.71e-51 Body mass index (adult); LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg14178294 chr17:43109690 DCAKD -0.37 -5.97 -0.31 6.09e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg24675658 chr1:53192096 ZYG11B -0.55 -8.51 -0.42 6.02e-16 Monocyte count; LUSC cis rs7296418 0.630 rs28419092 chr12:123812629 G/C cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.12 -0.41 9.24e-15 Platelet count; LUSC trans rs7937682 0.889 rs1940529 chr11:111498523 G/C cg18187862 chr3:45730750 SACM1L 0.55 7.05 0.36 1.03e-11 Primary sclerosing cholangitis; LUSC cis rs7075426 0.905 rs10887612 chr10:88213946 T/C cg07322936 chr10:88137208 NA 0.55 8.24 0.41 3.87e-15 Migraine without aura; LUSC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg11764359 chr7:65958608 NA 0.69 10.82 0.51 1.38e-23 Aortic root size; LUSC cis rs7647973 0.593 rs55997059 chr3:49858661 A/T cg13072238 chr3:49761600 GMPPB 0.67 8.62 0.43 2.76e-16 Menarche (age at onset); LUSC cis rs9323205 0.911 rs60034431 chr14:51622437 C/A cg23942311 chr14:51606299 NA -0.49 -10.16 -0.49 2.56e-21 Cancer; LUSC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23248424 chr5:179741104 GFPT2 -0.57 -8.9 -0.44 3.53e-17 Height; LUSC trans rs2587949 0.593 rs1817576 chr3:4205925 T/C cg15139668 chr4:4577005 NA -0.41 -6.15 -0.32 2.21e-9 Periodontitis (DPAL); LUSC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg22903657 chr4:1355424 KIAA1530 -0.37 -6.04 -0.31 4.01e-9 Longevity; LUSC cis rs7582180 0.629 rs6757754 chr2:100951273 C/T cg12002119 chr2:101014098 CHST10 -0.35 -5.78 -0.3 1.76e-8 Intelligence (multi-trait analysis); LUSC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg14583973 chr4:3374767 RGS12 -0.34 -7.57 -0.38 3.74e-13 Serum sulfate level; LUSC cis rs4343996 0.521 rs10277545 chr7:3424362 C/T cg21248987 chr7:3385318 SDK1 0.38 6.41 0.33 4.97e-10 Motion sickness; LUSC trans rs9409565 0.826 rs2769813 chr9:97151194 C/T cg05679027 chr9:99775184 HIATL2 0.46 6.6 0.34 1.6e-10 Colorectal cancer (alcohol consumption interaction); LUSC cis rs62400317 0.762 rs12215263 chr6:44831364 C/A cg18551225 chr6:44695536 NA -0.47 -7.55 -0.38 4.13e-13 Total body bone mineral density; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24102266 chr1:33219584 KIAA1522 -0.42 -6.13 -0.32 2.43e-9 Electrocardiographic conduction measures; LUSC cis rs7824557 0.524 rs7835318 chr8:10953874 G/A cg21775007 chr8:11205619 TDH -0.5 -7.6 -0.38 3.07e-13 Retinal vascular caliber; LUSC cis rs9398803 1.000 rs9398803 chr6:126683594 A/G cg19875578 chr6:126661172 C6orf173 0.42 6.08 0.32 3.25e-9 Male-pattern baldness; LUSC cis rs8141529 0.632 rs5762803 chr22:29193638 G/C cg15103426 chr22:29168792 CCDC117 0.51 6.81 0.35 4.42e-11 Lymphocyte counts; LUSC cis rs4073582 0.595 rs801736 chr11:65928430 A/T cg16950941 chr11:66035639 RAB1B 0.5 7.28 0.37 2.42e-12 Gout; LUSC cis rs2219968 1.000 rs2128017 chr8:78964682 T/G cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg24838063 chr12:130822603 PIWIL1 0.69 10.79 0.51 1.69e-23 Menopause (age at onset); LUSC cis rs1461503 0.966 rs10790546 chr11:122838426 C/A cg27398637 chr11:122830231 C11orf63 -0.4 -6.37 -0.33 6.12e-10 Menarche (age at onset); LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11905131 chr22:24372483 LOC391322 0.5 8.51 0.42 5.92e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7572733 0.534 rs700681 chr2:198711502 C/A cg00792783 chr2:198669748 PLCL1 0.43 5.87 0.31 1.04e-8 Dermatomyositis; LUSC cis rs6545883 0.899 rs12473030 chr2:61720497 T/A cg15711740 chr2:61764176 XPO1 -0.5 -7.77 -0.39 9.55e-14 Tuberculosis; LUSC trans rs75804782 0.641 rs72985387 chr2:239336589 G/A cg01134436 chr17:81009848 B3GNTL1 0.63 6.13 0.32 2.54e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs6961069 0.645 rs10261980 chr7:80224566 A/T cg04458919 chr7:80252533 CD36 -0.41 -7.25 -0.37 2.89e-12 Platelet count; LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg08219700 chr8:58056026 NA 0.63 8.05 0.4 1.45e-14 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.765 rs1094409 chr1:153021040 T/A cg00922841 chr1:152955080 SPRR1A -0.43 -7.54 -0.38 4.53e-13 Inflammatory skin disease; LUSC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg11645453 chr3:52864694 ITIH4 0.59 14.12 0.61 8.31e-36 Schizophrenia; LUSC cis rs7647973 0.961 rs6778080 chr3:49317338 C/T cg07636037 chr3:49044803 WDR6 -0.6 -7.66 -0.39 2.01e-13 Menarche (age at onset); LUSC cis rs3126085 0.935 rs2152862 chr1:152259742 T/C cg26876637 chr1:152193138 HRNR -0.45 -6.07 -0.32 3.45e-9 Atopic dermatitis; LUSC cis rs4478858 0.684 rs10798838 chr1:31719450 G/A cg00250761 chr1:31883323 NA -0.33 -8.03 -0.4 1.71e-14 Alcohol dependence; LUSC cis rs7647973 0.925 rs6446256 chr3:49224210 A/G cg07636037 chr3:49044803 WDR6 0.69 8.87 0.44 4.38e-17 Menarche (age at onset); LUSC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg16049864 chr8:95962084 TP53INP1 0.64 10.88 0.51 8.45e-24 Type 2 diabetes; LUSC cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg02155558 chr15:43621948 ADAL;LCMT2 1.06 11.28 0.53 3.2e-25 Lung cancer in ever smokers; LUSC cis rs477692 0.935 rs554458 chr10:131427372 A/G cg11019008 chr10:131425282 MGMT 0.43 6.48 0.33 3.21e-10 Response to temozolomide; LUSC cis rs2607426 0.681 rs2545777 chr19:41287809 C/T cg05508168 chr19:41255947 C19orf54;SNRPA 0.97 7.37 0.37 1.34e-12 Blood protein levels; LUSC cis rs5769707 0.681 rs4824068 chr22:50024801 G/A cg20744362 chr22:50050164 C22orf34 0.39 7.32 0.37 1.81e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11055034 0.560 rs2024385 chr12:12888438 A/T cg09462578 chr12:12878428 APOLD1 0.6 9.77 0.47 5.34e-20 Birth weight; LUSC cis rs4728302 0.534 rs6976069 chr7:133152898 T/C cg10665199 chr7:133106180 EXOC4 0.54 7.7 0.39 1.58e-13 Intelligence;Intelligence (multi-trait analysis); LUSC cis rs752010 0.695 rs12123834 chr1:42105727 T/C cg06885757 chr1:42089581 HIVEP3 0.44 8.57 0.42 3.9e-16 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg25643088 chr3:52874325 TMEM110 0.4 6.17 0.32 2.01e-9 Schizophrenia; LUSC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg16928487 chr17:17741425 SREBF1 -0.43 -7.97 -0.4 2.52e-14 Total body bone mineral density; LUSC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg20848291 chr7:100343083 ZAN -0.67 -9.29 -0.45 1.97e-18 Other erythrocyte phenotypes; LUSC cis rs4851254 0.660 rs114552491 chr2:100709533 C/T cg22139774 chr2:100720529 AFF3 -0.43 -5.75 -0.3 1.99e-8 Intelligence (multi-trait analysis); LUSC cis rs11711311 1.000 rs9811353 chr3:113483979 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.41 -5.65 -0.3 3.48e-8 IgG glycosylation; LUSC cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg08807101 chr21:30365312 RNF160 0.69 11.24 0.52 4.35e-25 Pancreatic cancer; LUSC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.29 0.33 9.72e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1943345 0.536 rs12269817 chr11:82858667 T/C cg07047830 chr11:82868014 PCF11 0.71 11.83 0.54 3.38e-27 Obesity-related traits; LUSC cis rs2562456 0.917 rs2681377 chr19:21716520 T/C cg00806126 chr19:22604979 ZNF98 0.37 5.75 0.3 2e-8 Pain; LUSC cis rs2839186 0.900 rs2839200 chr21:47709095 C/T cg11766577 chr21:47581405 C21orf56 -0.42 -6.12 -0.32 2.6e-9 Testicular germ cell tumor; LUSC cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg18132916 chr6:79620363 NA -0.39 -6.02 -0.31 4.69e-9 Intelligence (multi-trait analysis); LUSC cis rs8179 0.645 rs11767704 chr7:92256375 C/T cg15732164 chr7:92237376 CDK6 -0.41 -5.8 -0.3 1.5e-8 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs2204008 0.522 rs117743143 chr12:38030824 C/T cg13010199 chr12:38710504 ALG10B 0.61 9.55 0.46 2.98e-19 Bladder cancer; LUSC cis rs524023 0.914 rs4930556 chr11:64377726 G/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.44 -0.5 2.88e-22 Urate levels in obese individuals; LUSC cis rs500891 0.645 rs1143795 chr6:83995167 G/C cg08257003 chr6:84140564 ME1 0.33 7.15 0.36 5.67e-12 Platelet-derived growth factor BB levels; LUSC cis rs921665 0.749 rs7563563 chr2:3201417 A/G cg02624386 chr2:3182749 NA -0.57 -6.03 -0.31 4.27e-9 World class endurance athleticism; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.43 0.53 8.95e-26 Prudent dietary pattern; LUSC cis rs4474465 0.790 rs4544031 chr11:78265403 G/C cg27205649 chr11:78285834 NARS2 0.52 6.12 0.32 2.64e-9 Alzheimer's disease (survival time); LUSC cis rs11190604 0.767 rs11190513 chr10:102165238 A/G cg07080220 chr10:102295463 HIF1AN 0.59 7.64 0.39 2.24e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.09 -0.36 8.24e-12 Asthma; LUSC cis rs79839061 0.610 rs11726280 chr4:864077 C/T cg14530993 chr4:882597 GAK 0.73 7.39 0.37 1.17e-12 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg18765753 chr7:1198926 ZFAND2A -0.54 -9.89 -0.48 2.15e-20 Longevity;Endometriosis; LUSC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg15556689 chr8:8085844 FLJ10661 0.48 6.18 0.32 1.87e-9 Obesity-related traits; LUSC cis rs7572644 0.699 rs13416434 chr2:28162274 T/C cg27432699 chr2:27873401 GPN1 -0.52 -6.94 -0.35 2.06e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7615316 1.000 rs2030613 chr3:142343391 G/A cg16271453 chr3:142027066 XRN1 -0.35 -6.06 -0.31 3.69e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2274273 1.000 rs57970196 chr14:55600405 C/T cg04306507 chr14:55594613 LGALS3 0.54 11.49 0.53 5.85e-26 Protein biomarker; LUSC trans rs3857536 0.719 rs9363555 chr6:66930332 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.23 -0.32 1.4e-9 Blood trace element (Cu levels); LUSC cis rs4443100 0.917 rs5996460 chr22:23393090 G/A cg14186256 chr22:23484241 RTDR1 0.5 6.24 0.32 1.3e-9 Serum parathyroid hormone levels; LUSC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.59 -9.5 -0.46 4.13e-19 Prudent dietary pattern; LUSC cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg26061582 chr7:22766209 IL6 0.45 6.61 0.34 1.55e-10 Lung cancer; LUSC cis rs12928939 0.954 rs34998650 chr16:71829329 T/C cg03805757 chr16:71968109 PKD1L3 -0.46 -6.65 -0.34 1.23e-10 Post bronchodilator FEV1; LUSC trans rs561341 1.000 rs506766 chr17:30289659 T/C cg20587970 chr11:113659929 NA -1.29 -16.75 -0.68 3.69e-46 Hip circumference adjusted for BMI; LUSC cis rs1215050 0.740 rs783949 chr4:99001933 A/G cg05340658 chr4:99064831 C4orf37 -0.46 -7.16 -0.36 5.26e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg24642439 chr20:33292090 TP53INP2 0.76 12.14 0.55 2.44e-28 Coronary artery disease; LUSC cis rs11971779 0.818 rs12056045 chr7:139025430 C/G cg07862535 chr7:139043722 LUC7L2 0.72 8.03 0.4 1.7e-14 Diisocyanate-induced asthma; LUSC cis rs7746199 0.736 rs58616630 chr6:27474715 A/G cg09904177 chr6:26538194 HMGN4 -0.76 -5.96 -0.31 6.44e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs7681423 0.951 rs6050 chr4:155507590 C/T cg20735720 chr4:155535218 FGG 0.48 7.44 0.38 8.67e-13 Fibrinogen; LUSC cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg01657329 chr11:68192670 LRP5 0.44 6.47 0.33 3.58e-10 Total body bone mineral density; LUSC cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs4363385 0.642 rs58124215 chr1:152916375 C/T cg08895932 chr1:152778580 LCE1C -0.33 -5.87 -0.31 1.03e-8 Inflammatory skin disease; LUSC cis rs6961069 0.585 rs62461693 chr7:80248259 T/C cg04458919 chr7:80252533 CD36 -0.4 -7.01 -0.36 1.3e-11 Platelet count; LUSC cis rs4363385 0.588 rs6660878 chr1:153027068 A/G cg00922841 chr1:152955080 SPRR1A -0.37 -6.24 -0.32 1.31e-9 Inflammatory skin disease; LUSC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg01570182 chr17:44337453 NA 0.71 10.7 0.51 3.74e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04459753 chr16:28858035 TUFM 0.43 6.22 0.32 1.48e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs11098499 0.690 rs34818745 chr4:120257055 T/C cg25214090 chr10:38739885 LOC399744 0.5 7.27 0.37 2.52e-12 Corneal astigmatism; LUSC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.55 0.62 1.76e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10875746 0.903 rs10875740 chr12:48489117 C/T cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC trans rs9291879 0.551 rs7721781 chr5:66532920 C/T cg04621676 chr1:9599380 SLC25A33 -0.45 -6.06 -0.31 3.66e-9 Gut microbiota (bacterial taxa); LUSC trans rs961253 0.556 rs6076983 chr20:6331376 C/T cg17788362 chr6:86352627 SYNCRIP 0.41 5.98 0.31 5.82e-9 Colorectal cancer; LUSC cis rs6429082 0.791 rs291394 chr1:235651682 A/G cg26050004 chr1:235667680 B3GALNT2 0.61 8.34 0.41 2.03e-15 Adiposity; LUSC cis rs9467711 0.516 rs629444 chr6:25885814 A/G cg08501292 chr6:25962987 TRIM38 -0.62 -6.3 -0.33 9.55e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs62400317 0.859 rs62436760 chr6:45112604 T/C cg20913747 chr6:44695427 NA -0.46 -7.38 -0.37 1.25e-12 Total body bone mineral density; LUSC trans rs72674100 1.000 rs10016960 chr4:97989075 T/A cg09670535 chr1:18959427 PAX7 -0.62 -6.34 -0.33 7.58e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs56283067 0.887 rs9463043 chr6:44771114 T/C cg18551225 chr6:44695536 NA -0.45 -7.21 -0.37 3.73e-12 Total body bone mineral density; LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg18876405 chr7:65276391 NA 0.54 8.7 0.43 1.51e-16 Calcium levels; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg00945038 chr17:61921165 SMARCD2 0.54 9.61 0.47 1.85e-19 Prudent dietary pattern; LUSC cis rs753778 0.962 rs2043422 chr8:142236337 C/T cg18755752 chr8:142205143 DENND3 -0.47 -6.52 -0.34 2.6e-10 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC trans rs1973993 0.745 rs6593602 chr1:96951281 G/A cg10631902 chr5:14652156 NA -0.45 -6.66 -0.34 1.15e-10 Weight; LUSC trans rs11098499 0.754 rs1511017 chr4:120250805 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs11098499 0.913 rs35271032 chr4:120156659 C/T cg09307838 chr4:120376055 NA 0.69 10.01 0.48 8.32e-21 Corneal astigmatism; LUSC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg19622623 chr12:86230825 RASSF9 -0.44 -6.22 -0.32 1.46e-9 Major depressive disorder; LUSC cis rs6541297 1.000 rs2144298 chr1:230280198 T/C cg20703242 chr1:230279135 GALNT2 0.56 8.61 0.43 2.97e-16 Coronary artery disease; LUSC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg22875332 chr1:76189707 ACADM 0.86 15.73 0.65 4.27e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs250677 0.958 rs36078 chr5:148430567 G/A cg12140854 chr5:148520817 ABLIM3 -0.39 -6.07 -0.32 3.43e-9 Breast cancer; LUSC cis rs1942 0.837 rs12440045 chr15:41782684 A/C cg18705301 chr15:41695430 NDUFAF1 -0.47 -7.84 -0.39 6.01e-14 Eosinophil percentage of granulocytes; LUSC cis rs3099143 1.000 rs4243043 chr15:77178540 A/G cg21673338 chr15:77095150 SCAPER 0.8 7.8 0.39 8.1e-14 Recalcitrant atopic dermatitis; LUSC cis rs7705502 1.000 rs72810989 chr5:173326714 A/G cg18693985 chr5:173351052 CPEB4 -0.37 -5.85 -0.3 1.19e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs9419702 0.568 rs11156445 chr10:133542301 T/C cg04492858 chr10:133558786 NA 0.42 6.98 0.36 1.57e-11 Survival in rectal cancer; LUSC cis rs7246657 0.943 rs7257672 chr19:37823859 G/C cg23950597 chr19:37808831 NA -0.65 -7.91 -0.4 3.9e-14 Coronary artery calcification; LUSC cis rs1552244 0.507 rs6443274 chr3:9995288 A/T cg00166722 chr3:10149974 C3orf24 0.4 6.07 0.32 3.47e-9 Alzheimer's disease; LUSC cis rs28374715 0.681 rs8037574 chr15:41630770 T/C cg18705301 chr15:41695430 NDUFAF1 -0.94 -18.67 -0.71 8.71e-54 Ulcerative colitis; LUSC cis rs10499694 0.933 rs12718583 chr7:50582631 T/C cg18232548 chr7:50535776 DDC -0.39 -5.68 -0.3 2.88e-8 Body mass index; LUSC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.44 6.62 0.34 1.46e-10 Menarche (age at onset); LUSC cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 6.03 0.31 4.43e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18099408 chr3:52552593 STAB1 -0.4 -7.03 -0.36 1.19e-11 Electroencephalogram traits; LUSC cis rs4746818 0.643 rs2855020 chr10:70856510 C/T cg11621586 chr10:70884670 VPS26A 0.94 9.19 0.45 4.42e-18 Left atrial antero-posterior diameter; LUSC trans rs4332037 0.950 rs10267593 chr7:1937261 G/A cg25206134 chr2:45395956 NA 0.56 6.83 0.35 3.96e-11 Bipolar disorder; LUSC cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01500567 chr6:44355777 CDC5L 0.53 7.15 0.36 5.54e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.01 0.52 2.98e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg17366294 chr4:99064904 C4orf37 0.57 9.99 0.48 9.57e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.56 9.48 0.46 4.93e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6840360 1.000 rs751014 chr4:152601902 G/A cg22705602 chr4:152727874 NA -0.27 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.42 6.26 0.32 1.2e-9 Platelet count; LUSC cis rs7523050 0.908 rs12036331 chr1:109398707 A/T cg08274380 chr1:109419600 GPSM2 0.81 8.86 0.44 4.81e-17 Fat distribution (HIV); LUSC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg21724239 chr8:58056113 NA 0.55 6.37 0.33 6.1e-10 Developmental language disorder (linguistic errors); LUSC cis rs1670533 1.000 rs10084889 chr4:1053815 G/A cg27284194 chr4:1044797 NA 0.59 8.97 0.44 2.1e-17 Recombination rate (females); LUSC cis rs259282 0.602 rs194589 chr19:33144621 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.91 13.4 0.59 4.59e-33 Schizophrenia; LUSC trans rs56176327 0.532 rs9849038 chr3:49771990 A/G cg21659725 chr3:3221576 CRBN -0.66 -8.04 -0.4 1.57e-14 Intelligence (multi-trait analysis); LUSC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg13393036 chr8:95962371 TP53INP1 0.43 8.68 0.43 1.84e-16 Type 2 diabetes; LUSC cis rs67311347 0.544 rs6769627 chr3:40327845 G/A cg09455208 chr3:40491958 NA 0.43 7.96 0.4 2.77e-14 Renal cell carcinoma; LUSC cis rs2204008 0.837 rs11168387 chr12:37962818 G/A cg13010199 chr12:38710504 ALG10B -0.62 -9.56 -0.46 2.74e-19 Bladder cancer; LUSC cis rs6951245 0.572 rs75818004 chr7:1047572 C/T cg24642844 chr7:1081250 C7orf50 -0.71 -6.7 -0.34 9.1e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4072705 0.967 rs4838208 chr9:127528035 C/A cg13476313 chr9:127244764 NR5A1 0.3 5.67 0.3 3.13e-8 Menarche (age at onset); LUSC trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg11608241 chr8:8085544 FLJ10661 0.46 6.53 0.34 2.41e-10 Neuroticism; LUSC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg03806693 chr22:41940476 POLR3H 0.99 14.24 0.61 2.63e-36 Vitiligo; LUSC cis rs10779751 1.000 rs4845854 chr1:11261929 T/C cg08854313 chr1:11322531 MTOR 0.89 15.89 0.66 9.61e-43 Body mass index; LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg22920501 chr2:26401640 FAM59B 0.82 12.14 0.55 2.42e-28 Gut microbiome composition (summer); LUSC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.06 -0.31 3.68e-9 Life satisfaction; LUSC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC cis rs9815354 0.767 rs61283393 chr3:41854135 T/G cg03022575 chr3:42003672 ULK4 0.84 8.86 0.44 4.79e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg18681998 chr4:17616180 MED28 0.77 13.44 0.59 3.14e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3824867 0.920 rs4282946 chr11:47456202 G/A cg20307385 chr11:47447363 PSMC3 0.66 9.74 0.47 6.62e-20 Mean corpuscular hemoglobin; LUSC cis rs77633900 0.614 rs2469242 chr15:76876710 A/G cg21673338 chr15:77095150 SCAPER -0.69 -6.88 -0.35 2.95e-11 Non-glioblastoma glioma;Glioma; LUSC cis rs11190604 1.000 rs10883503 chr10:102275504 C/A cg16342193 chr10:102329863 NA -0.38 -6.76 -0.35 6.18e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg03351412 chr1:154909251 PMVK -0.46 -7.06 -0.36 9.75e-12 Prostate cancer; LUSC cis rs6542838 0.702 rs6739176 chr2:99536846 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.5 -7.04 -0.36 1.1e-11 Fear of minor pain; LUSC cis rs4253772 0.530 rs9615989 chr22:46803774 A/T cg00784671 chr22:46762841 CELSR1 -0.55 -5.78 -0.3 1.72e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs477692 0.544 rs7894836 chr10:131442595 T/A cg05714579 chr10:131428358 MGMT -0.77 -11.89 -0.55 2.08e-27 Response to temozolomide; LUSC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg06618935 chr21:46677482 NA -0.38 -7.72 -0.39 1.38e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7824557 0.527 rs2736305 chr8:11237773 T/C cg15556689 chr8:8085844 FLJ10661 -0.47 -7.04 -0.36 1.08e-11 Retinal vascular caliber; LUSC cis rs1185460 0.967 rs1168568 chr11:118949799 G/A cg23280166 chr11:118938394 VPS11 0.47 7.27 0.37 2.55e-12 Coronary artery disease; LUSC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg08847533 chr14:75593920 NEK9 0.86 16.11 0.66 1.35e-43 Height; LUSC cis rs3007168 1.000 rs2999356 chr14:51606543 A/G cg23942311 chr14:51606299 NA 0.36 5.99 0.31 5.57e-9 Cancer; LUSC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.44 0.33 4.25e-10 Menopause (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25632300 chr5:174905618 SFXN1 -0.36 -6.5 -0.34 2.86e-10 Electrocardiographic conduction measures; LUSC cis rs8060686 0.565 rs8044328 chr16:68146859 G/C cg04539111 chr16:67997858 SLC12A4 -0.42 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg03684893 chr10:554711 DIP2C -0.34 -6.1 -0.32 2.93e-9 Psychosis in Alzheimer's disease; LUSC cis rs6940638 0.688 rs9461335 chr6:27138529 C/A cg09904177 chr6:26538194 HMGN4 -0.47 -6.77 -0.35 5.64e-11 Intelligence (multi-trait analysis); LUSC cis rs7903847 0.642 rs10786344 chr10:99165975 T/C cg08345082 chr10:99160200 RRP12 -0.35 -7.22 -0.37 3.46e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs35828350 1 rs35828350 chr15:85355841 G/A cg17173187 chr15:85201210 NMB 0.51 9.44 0.46 6.57e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs422249 0.593 rs174613 chr11:61628492 G/A cg06860612 chr11:61641270 FADS3 0.28 5.85 0.31 1.14e-8 Trans fatty acid levels; LUSC cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg24690094 chr11:67383802 NA -0.45 -8.33 -0.41 2.14e-15 Mean corpuscular volume; LUSC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg11279151 chr3:101281821 RG9MTD1 -0.4 -5.67 -0.3 3.1e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs7799006 0.964 rs3757440 chr7:2272936 A/G cg02951883 chr7:2050386 MAD1L1 -0.33 -5.76 -0.3 1.86e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6121246 0.567 rs6060297 chr20:30198560 A/G cg18721089 chr20:30220636 NA -0.37 -5.85 -0.3 1.19e-8 Mean corpuscular hemoglobin; LUSC cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg06784218 chr1:46089804 CCDC17 -0.49 -9.89 -0.48 2.18e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg18402987 chr7:1209562 NA 0.66 6.96 0.36 1.84e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.47 -6.69 -0.34 9.19e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg13902645 chr11:5959945 NA -0.55 -8.69 -0.43 1.64e-16 DNA methylation (variation); LUSC cis rs11958404 0.932 rs72816549 chr5:157417957 G/A cg05962755 chr5:157440814 NA 0.51 6.21 0.32 1.58e-9 IgG glycosylation; LUSC cis rs977987 0.806 rs12933281 chr16:75483064 T/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.91 -0.35 2.5e-11 Dupuytren's disease; LUSC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg08027265 chr7:2291960 NA -0.36 -5.73 -0.3 2.24e-8 Bipolar disorder and schizophrenia; LUSC cis rs11190604 1.000 rs7099965 chr10:102301165 A/G cg16342193 chr10:102329863 NA -0.34 -5.94 -0.31 7.31e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12122100 0.862 rs6689542 chr1:146506881 G/C cg03526459 chr1:146549940 NA -0.41 -6.69 -0.34 9.32e-11 HIV-1 control; LUSC cis rs2219968 1.000 rs13276123 chr8:78975338 G/A cg00738934 chr8:78996279 NA 0.35 6.23 0.32 1.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg11766577 chr21:47581405 C21orf56 -0.48 -7.32 -0.37 1.86e-12 Testicular germ cell tumor; LUSC trans rs34421088 0.576 rs2572432 chr8:11101723 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -6.38 -0.33 5.88e-10 Neuroticism; LUSC trans rs8030485 0.571 rs7182891 chr15:79438697 G/A cg16586880 chr8:140854244 TRAPPC9 -0.39 -6.36 -0.33 6.68e-10 Left ventricle wall thickness; LUSC trans rs89107 0.688 rs422833 chr6:118608971 T/C cg11574620 chr4:80246899 NAA11 -0.36 -5.95 -0.31 6.73e-9 Cardiac structure and function; LUSC cis rs9658691 0.607 rs3740281 chr10:90772150 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.61 -6.17 -0.32 1.95e-9 Mosquito bite size; LUSC cis rs10761482 0.638 rs10761507 chr10:62243232 G/T cg18175470 chr10:62150864 ANK3 0.5 7.0 0.36 1.4e-11 Schizophrenia; LUSC trans rs61931739 0.500 rs7488438 chr12:34531359 G/T cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg02675527 chr2:114030824 PAX8;LOC440839 0.36 5.71 0.3 2.55e-8 Lymphocyte counts; LUSC cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg00071950 chr4:10020882 SLC2A9 0.59 9.55 0.46 2.93e-19 Bone mineral density; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg14872580 chr5:162886528 HMMR;NUDCD2 0.4 6.07 0.32 3.42e-9 Schizophrenia; LUSC cis rs7572733 0.534 rs700685 chr2:198715972 A/G cg00792783 chr2:198669748 PLCL1 0.43 5.87 0.31 1.07e-8 Dermatomyositis; LUSC cis rs7824557 0.620 rs6996368 chr8:11182704 G/A cg21775007 chr8:11205619 TDH 0.78 13.16 0.58 3.74e-32 Retinal vascular caliber; LUSC cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg12310025 chr6:25882481 NA -0.46 -8.61 -0.43 2.96e-16 Blood metabolite levels; LUSC cis rs9650315 0.866 rs34495936 chr8:57196273 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.63 0.34 1.35e-10 Height; LUSC cis rs1577917 1.000 rs12154056 chr6:86634094 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.47 -0.42 7.8e-16 Response to antipsychotic treatment; LUSC cis rs7223966 1.000 rs1877316 chr17:61766880 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.65 0.34 1.17e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs711244 0.532 rs12104444 chr2:37253433 T/C cg14987922 chr2:37194071 STRN 0.53 7.68 0.39 1.75e-13 Mean platelet volume; LUSC cis rs10504229 0.679 rs16921677 chr8:58052431 T/C cg11062466 chr8:58055876 NA 0.49 6.52 0.34 2.59e-10 Developmental language disorder (linguistic errors); LUSC cis rs1775715 0.966 rs1251386 chr10:32319114 C/T cg26784012 chr10:32216390 ARHGAP12 -0.38 -6.23 -0.32 1.39e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg16339924 chr4:17578868 LAP3 0.51 7.6 0.38 2.99e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs2243480 1.000 rs4718334 chr7:65789454 G/A cg10756647 chr7:56101905 PSPH -0.84 -8.46 -0.42 8.28e-16 Diabetic kidney disease; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg05025164 chr4:1340916 KIAA1530 0.45 7.04 0.36 1.13e-11 Longevity; LUSC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg07701084 chr6:150067640 NUP43 0.55 8.29 0.41 2.84e-15 Lung cancer; LUSC cis rs7590720 1.000 rs934154 chr2:216901933 C/T cg12620499 chr2:216877984 MREG 0.93 14.09 0.61 1.09e-35 Alcohol dependence; LUSC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg08219700 chr8:58056026 NA 0.53 6.57 0.34 1.89e-10 Developmental language disorder (linguistic errors); LUSC trans rs11992162 0.591 rs35657308 chr8:11804402 G/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.08 -0.32 3.24e-9 Monocyte count; LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg20093808 chr2:9563643 ITGB1BP1;CPSF3 0.51 6.54 0.34 2.26e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9646954 0.560 rs4149507 chr2:101032745 C/T cg12002119 chr2:101014098 CHST10 0.37 6.26 0.32 1.17e-9 Intelligence (multi-trait analysis); LUSC trans rs72674100 1.000 rs78448853 chr4:97966420 G/A cg09670535 chr1:18959427 PAX7 -0.64 -6.12 -0.32 2.68e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12200560 0.505 rs211165 chr6:97068520 A/T cg06623918 chr6:96969491 KIAA0776 0.49 7.02 0.36 1.26e-11 Coronary heart disease; LUSC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg17376030 chr22:41985996 PMM1 0.49 6.04 0.31 4.13e-9 Vitiligo; LUSC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg11663144 chr21:46675770 NA -0.42 -7.21 -0.37 3.67e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9462027 0.628 rs7742652 chr6:34667075 G/A cg07306190 chr6:34760872 UHRF1BP1 0.35 6.3 0.33 9.15e-10 Systemic lupus erythematosus; LUSC cis rs921968 0.612 rs573555 chr2:219348888 A/C cg02176678 chr2:219576539 TTLL4 0.6 10.68 0.5 4.11e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs9925964 0.933 rs9939417 chr16:31053467 C/T cg02466173 chr16:30829666 NA 0.37 6.63 0.34 1.34e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11890956 chr21:40555474 PSMG1 -0.72 -11.24 -0.52 4.47e-25 Menarche (age at onset); LUSC cis rs4891159 0.824 rs17059362 chr18:74144307 G/A cg24786174 chr18:74118243 ZNF516 -0.83 -15.32 -0.64 1.67e-40 Longevity; LUSC cis rs7937682 0.924 rs11213968 chr11:111527629 G/C cg09085632 chr11:111637200 PPP2R1B -1.11 -18.21 -0.71 5.74e-52 Primary sclerosing cholangitis; LUSC cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg08754478 chr10:133766260 PPP2R2D -0.6 -7.45 -0.38 7.81e-13 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs67478160 0.634 rs2144080 chr14:104258761 A/C cg08213375 chr14:104286397 PPP1R13B 0.45 8.76 0.43 9.72e-17 Schizophrenia; LUSC cis rs7937682 1.000 rs7121011 chr11:111568681 C/T cg09085632 chr11:111637200 PPP2R1B 1.08 15.88 0.66 1.05e-42 Primary sclerosing cholangitis; LUSC cis rs9356171 0.572 rs2322175 chr6:164328086 G/C cg25752492 chr6:164341247 NA -0.38 -6.44 -0.33 4.08e-10 Diisocyanate-induced asthma; LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg21782813 chr7:2030301 MAD1L1 0.54 9.25 0.45 2.71e-18 Bipolar disorder and schizophrenia; LUSC trans rs11098499 0.780 rs12504773 chr4:120562149 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.25 0.32 1.26e-9 Corneal astigmatism; LUSC cis rs68170813 0.641 rs4730248 chr7:107125939 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.38 -0.46 1.07e-18 Coronary artery disease; LUSC cis rs921968 0.565 rs12611632 chr2:219621258 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg00701064 chr4:6280414 WFS1 0.57 13.35 0.59 7.38e-33 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg09323728 chr8:95962352 TP53INP1 -0.39 -7.79 -0.39 8.62e-14 Type 2 diabetes; LUSC cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg17892150 chr10:133769511 PPP2R2D -0.65 -8.99 -0.44 1.89e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.73 0.39 1.27e-13 Gut microbiome composition (summer); LUSC cis rs9920506 0.518 rs11072774 chr15:78952697 C/T cg24631222 chr15:78858424 CHRNA5 0.55 6.54 0.34 2.36e-10 Post bronchodilator FEV1; LUSC cis rs7940866 0.845 rs10894294 chr11:130830748 G/T cg12179176 chr11:130786555 SNX19 0.62 9.57 0.46 2.52e-19 Schizophrenia; LUSC cis rs9457247 0.508 rs9459874 chr6:167504127 A/G cg07741184 chr6:167504864 NA -0.4 -7.17 -0.37 4.83e-12 Crohn's disease; LUSC cis rs721399 0.513 rs35354956 chr8:18241319 T/C cg18736775 chr8:18248649 NAT2 -0.58 -6.86 -0.35 3.36e-11 Blood metabolite levels; LUSC cis rs4900538 0.819 rs72698591 chr14:102838896 G/A cg18135206 chr14:102964638 TECPR2 -0.98 -18.49 -0.71 4.61e-53 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1832871 0.672 rs9457344 chr6:158742043 C/T cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs6977660 0.660 rs10239332 chr7:19824465 A/G cg05791153 chr7:19748676 TWISTNB 0.67 6.98 0.36 1.55e-11 Thyroid stimulating hormone; LUSC cis rs951366 0.539 rs1935025 chr1:205692084 C/A cg14893161 chr1:205819251 PM20D1 -0.47 -6.44 -0.33 4.23e-10 Menarche (age at onset); LUSC cis rs2273669 0.667 rs7766248 chr6:109347262 C/T cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs185694 0.779 rs628483 chr13:30895462 C/T cg07600127 chr13:30881527 KATNAL1 -0.52 -6.22 -0.32 1.53e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; LUSC cis rs240764 0.755 rs12206564 chr6:100987009 A/G cg09795085 chr6:101329169 ASCC3 -0.41 -5.99 -0.31 5.47e-9 Neuroticism; LUSC cis rs5769765 0.778 rs4574208 chr22:50256738 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.8 10.55 0.5 1.24e-22 Schizophrenia; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14258366 chr7:41982794 NA 0.79 6.4 0.33 5.35e-10 Cognitive performance; LUSC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg15664640 chr17:80829946 TBCD -0.48 -8.55 -0.42 4.57e-16 Breast cancer; LUSC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg00825309 chr19:58991885 ZNF446 -0.5 -7.23 -0.37 3.27e-12 Uric acid clearance; LUSC cis rs7512552 0.839 rs1627235 chr1:150358858 C/T cg15654264 chr1:150340011 RPRD2 0.65 10.86 0.51 9.95e-24 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg00083206 chr6:110721305 DDO -0.45 -8.17 -0.41 6.26e-15 Platelet distribution width; LUSC cis rs1505368 0.781 rs4673664 chr2:213277649 T/C cg16329650 chr2:213403929 ERBB4 0.54 8.78 0.43 8.92e-17 Symmetrical dimethylarginine levels; LUSC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg02549819 chr16:58548995 SETD6 0.96 9.01 0.44 1.62e-17 Schizophrenia; LUSC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg21782813 chr7:2030301 MAD1L1 -0.52 -9.25 -0.45 2.68e-18 Bipolar disorder and schizophrenia; LUSC cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg06627557 chr7:32535165 LSM5;AVL9 -1.04 -20.49 -0.75 5.24e-61 Cognitive ability; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg00945038 chr17:61921165 SMARCD2 -0.43 -7.27 -0.37 2.63e-12 Prudent dietary pattern; LUSC cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg03647239 chr10:116582469 FAM160B1 0.48 7.67 0.39 1.96e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg22963979 chr7:1858916 MAD1L1 -0.48 -7.2 -0.37 3.89e-12 Bipolar disorder and schizophrenia; LUSC trans rs9886428 1.000 rs34786320 chr8:14115490 G/C cg11959399 chr20:741723 C20orf54 -0.4 -6.45 -0.33 3.98e-10 IgG glycosylation; LUSC cis rs3020736 0.500 rs6002597 chr22:42488160 C/A cg05082376 chr22:42548792 NA 0.42 6.39 0.33 5.56e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs8078723 0.966 rs57065891 chr17:38168227 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.93 -0.35 2.15e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs28829049 0.597 rs2296107 chr1:19476649 C/G cg13387374 chr1:19411106 UBR4 0.41 5.86 0.31 1.09e-8 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg25767906 chr1:53392781 SCP2 -0.51 -9.15 -0.45 5.83e-18 Monocyte count; LUSC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg03526776 chr6:41159608 TREML2 0.32 6.12 0.32 2.68e-9 Alzheimer's disease (late onset); LUSC cis rs2228479 0.681 rs7199685 chr16:89959805 G/C cg04013166 chr16:89971882 TCF25 0.64 7.68 0.39 1.76e-13 Skin colour saturation; LUSC cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg05347473 chr6:146136440 FBXO30 0.51 8.55 0.42 4.64e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs9300255 0.602 rs2510885 chr12:123614813 G/C cg13010344 chr12:123464640 ARL6IP4 -0.46 -6.37 -0.33 6.41e-10 Neutrophil percentage of white cells; LUSC cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 12.26 0.56 8.55e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg00255919 chr5:131827918 IRF1 -0.44 -8.3 -0.41 2.66e-15 Asthma (sex interaction); LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg24675658 chr1:53192096 ZYG11B -0.7 -11.8 -0.54 4.37e-27 Monocyte count; LUSC cis rs500891 1.000 rs13203062 chr6:84180038 A/G cg08257003 chr6:84140564 ME1 -0.34 -7.1 -0.36 7.33e-12 Platelet-derived growth factor BB levels; LUSC cis rs870825 0.616 rs2141258 chr4:185609576 A/C cg04058563 chr4:185651563 MLF1IP -0.84 -12.9 -0.58 3.69e-31 Blood protein levels; LUSC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg20135002 chr11:47629003 NA -0.53 -8.13 -0.41 8.36e-15 Subjective well-being; LUSC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg16680214 chr1:154839983 KCNN3 -0.52 -9.48 -0.46 4.88e-19 Prostate cancer; LUSC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg03452623 chr4:187889614 NA -0.91 -19.08 -0.72 2.06e-55 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.649 rs2064189 chr22:42127999 A/G cg03806693 chr22:41940476 POLR3H 0.86 12.59 0.57 5.03e-30 Vitiligo; LUSC cis rs10761482 0.813 rs4948409 chr10:62115820 C/T cg18175470 chr10:62150864 ANK3 -0.48 -6.92 -0.35 2.37e-11 Schizophrenia; LUSC cis rs763121 0.853 rs5757181 chr22:39013522 G/A cg14440974 chr22:39074834 NA -0.38 -6.37 -0.33 6.2e-10 Menopause (age at onset); LUSC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg05552183 chr6:42928497 GNMT 0.47 7.81 0.39 7.71e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4689388 0.890 rs4501291 chr4:6298582 C/T cg25554036 chr4:6271136 WFS1 0.6 12.22 0.56 1.26e-28 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg14993813 chr1:46806288 NSUN4 -0.52 -7.31 -0.37 2.03e-12 Menopause (age at onset); LUSC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg05535760 chr7:792225 HEATR2 -0.92 -9.63 -0.47 1.61e-19 Cerebrospinal P-tau181p levels; LUSC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg18402987 chr7:1209562 NA 0.43 5.83 0.3 1.34e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.69 -0.34 9.46e-11 Monocyte percentage of white cells; LUSC trans rs61931739 0.635 rs1601627 chr12:33962420 G/A cg13010199 chr12:38710504 ALG10B 0.4 6.03 0.31 4.38e-9 Morning vs. evening chronotype; LUSC cis rs9677476 0.955 rs9973370 chr2:232095587 A/G cg07929768 chr2:232055508 NA 0.31 6.1 0.32 2.93e-9 Food antigen IgG levels; LUSC cis rs11190604 1.000 rs7079136 chr10:102292709 T/C cg23241863 chr10:102295624 HIF1AN 0.49 5.98 0.31 5.84e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg15445000 chr17:37608096 MED1 -0.39 -6.71 -0.34 8.43e-11 Glomerular filtration rate (creatinine); LUSC cis rs2742234 0.504 rs10899780 chr10:43725796 T/C cg15436174 chr10:43711423 RASGEF1A 0.44 7.08 0.36 8.82e-12 Hirschsprung disease; LUSC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg20476274 chr7:133979776 SLC35B4 0.87 17.01 0.68 3.4e-47 Mean platelet volume; LUSC cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg09184832 chr6:79620586 NA -0.44 -7.24 -0.37 3.16e-12 Intelligence (multi-trait analysis); LUSC cis rs4803468 1.000 rs10417311 chr19:41902038 G/A cg09537434 chr19:41945824 ATP5SL -0.89 -15.75 -0.65 3.35e-42 Height; LUSC trans rs1325195 0.506 rs2636265 chr1:179199076 A/G cg11624085 chr17:8464688 MYH10 0.41 6.69 0.34 9.35e-11 IgE grass sensitization; LUSC cis rs4664304 0.966 rs3792198 chr2:160760338 G/A cg03641300 chr2:160917029 PLA2R1 -0.42 -6.79 -0.35 5.22e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6714710 0.580 rs17489915 chr2:98420431 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs7605827 0.930 rs4668444 chr2:15515642 C/T cg19274914 chr2:15703543 NA 0.47 9.07 0.44 1.03e-17 Educational attainment (years of education); LUSC cis rs7568498 0.517 rs11678856 chr2:161925443 C/T cg22496339 chr2:162101262 NA -0.59 -7.93 -0.4 3.29e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); LUSC cis rs782590 0.837 rs809732 chr2:55914621 T/C cg03859395 chr2:55845619 SMEK2 0.85 15.18 0.64 5.99e-40 Metabolic syndrome; LUSC cis rs4077468 1.000 rs9662221 chr1:205915745 G/T cg07167872 chr1:205819463 PM20D1 -0.45 -6.58 -0.34 1.83e-10 Cystic fibrosis-related diabetes; LUSC cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.31 0.37 1.99e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs11039100 1.000 rs12361754 chr11:5828027 T/C cg05234568 chr11:5960015 NA -0.51 -5.73 -0.3 2.27e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs853679 0.607 rs13194781 chr6:27815639 A/G cg26958806 chr6:27640298 NA 0.83 6.57 0.34 1.94e-10 Depression; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.67 -10.21 -0.49 1.79e-21 Lymphocyte counts; LUSC trans rs62458065 0.640 rs10241303 chr7:32534203 T/G cg00845942 chr12:64062724 DPY19L2 -0.61 -7.62 -0.38 2.69e-13 Metabolite levels (HVA/MHPG ratio); LUSC cis rs708547 0.647 rs2293175 chr4:57861358 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.56 8.41 0.42 1.2e-15 Response to bleomycin (chromatid breaks); LUSC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg18350739 chr11:68623251 NA -0.37 -6.36 -0.33 6.73e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg06221963 chr1:154839813 KCNN3 -0.63 -14.62 -0.62 9.33e-38 Prostate cancer; LUSC cis rs73206853 0.563 rs73194026 chr12:111140219 G/T cg12870014 chr12:110450643 ANKRD13A 0.67 7.36 0.37 1.45e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs8062405 1.000 rs8055138 chr16:28891465 C/T cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs4803468 1.000 rs2569754 chr19:41936734 A/G cg09537434 chr19:41945824 ATP5SL -0.94 -16.08 -0.66 1.74e-43 Height; LUSC trans rs11603151 0.622 rs7106125 chr11:134505804 G/C cg16473511 chr2:192015759 STAT4 0.48 5.96 0.31 6.33e-9 Schizophrenia; LUSC cis rs9612 0.718 rs346531 chr19:44239927 T/C cg08581076 chr19:44259116 C19orf61 0.48 5.77 0.3 1.77e-8 Exhaled nitric oxide output; LUSC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg19717773 chr7:2847554 GNA12 -0.39 -6.08 -0.32 3.2e-9 Height; LUSC cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg03213289 chr20:61660250 NA 0.67 13.96 0.61 3.26e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs9467711 0.651 rs1045537 chr6:26096748 G/C cg08501292 chr6:25962987 TRIM38 0.65 5.92 0.31 7.84e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg03929089 chr4:120376271 NA 0.8 10.15 0.49 2.78e-21 Coronary artery disease; LUSC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg17385448 chr1:15911702 AGMAT 0.36 6.18 0.32 1.82e-9 Systolic blood pressure; LUSC cis rs7584330 0.638 rs13429533 chr2:238448712 A/G cg14458575 chr2:238380390 NA 0.46 7.98 0.4 2.44e-14 Prostate cancer; LUSC cis rs2387326 0.717 rs12261194 chr10:129944464 T/C cg16087940 chr10:129947807 NA -0.39 -6.0 -0.31 5e-9 Select biomarker traits; LUSC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg23172400 chr8:95962367 TP53INP1 -0.39 -8.02 -0.4 1.78e-14 Type 2 diabetes; LUSC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.59 7.88 0.4 4.54e-14 Lung function (FEV1/FVC); LUSC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg22823121 chr1:150693482 HORMAD1 -0.52 -7.34 -0.37 1.59e-12 Urate levels; LUSC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg17554472 chr22:41940697 POLR3H -0.47 -5.8 -0.3 1.56e-8 Vitiligo; LUSC cis rs8078723 0.714 rs2241244 chr17:38153554 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.4 0.38 1.1e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs10203711 1.000 rs4331454 chr2:239594474 G/A cg14580085 chr2:239553406 NA 0.42 7.07 0.36 9.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 1.000 rs5769764 chr22:50270784 G/A cg04176532 chr22:50317003 CRELD2 -0.4 -5.73 -0.3 2.28e-8 Schizophrenia; LUSC cis rs854765 0.547 rs2955359 chr17:17946730 T/C cg16928487 chr17:17741425 SREBF1 0.37 7.13 0.36 6.28e-12 Total body bone mineral density; LUSC cis rs10992471 0.528 rs10429459 chr9:95258119 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.37 6.34 0.33 7.49e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4253772 1.000 rs11705483 chr22:46630544 C/A cg18190219 chr22:46762943 CELSR1 -0.52 -6.06 -0.31 3.61e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs7567288 0.636 rs11896655 chr2:134458912 G/A cg12381416 chr3:14359266 NA 0.57 6.29 0.33 1.01e-9 Height; LUSC cis rs7804356 1.000 rs7805766 chr7:26865610 C/G cg03456212 chr7:26904342 SKAP2 -0.56 -6.44 -0.33 4.23e-10 Type 1 diabetes; LUSC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg14552801 chr7:65878734 NA -0.45 -6.45 -0.33 3.83e-10 Aortic root size; LUSC cis rs981844 0.603 rs13132437 chr4:154748006 T/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.33e-10 Response to statins (LDL cholesterol change); LUSC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg05347473 chr6:146136440 FBXO30 0.6 9.81 0.47 4.01e-20 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.954 rs4345162 chr4:120312959 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs765787 0.530 rs28733848 chr15:45516047 C/T cg25801113 chr15:45476975 SHF 0.34 7.0 0.36 1.37e-11 Uric acid levels; LUSC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg18225595 chr11:63971243 STIP1 0.43 7.08 0.36 8.34e-12 Platelet count; LUSC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg14583973 chr4:3374767 RGS12 0.38 8.1 0.41 1.02e-14 Serum sulfate level; LUSC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg26850624 chr5:429559 AHRR -0.41 -8.14 -0.41 8.12e-15 Cystic fibrosis severity; LUSC cis rs5758511 0.573 rs2284082 chr22:42240797 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.39 -7.39 -0.37 1.19e-12 Birth weight; LUSC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg21963583 chr11:68658836 MRPL21 0.54 8.12 0.41 9.27e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg06740227 chr12:86229804 RASSF9 0.39 6.09 0.32 3.05e-9 Major depressive disorder; LUSC cis rs1865760 0.622 rs9968910 chr6:26072095 A/C cg17691542 chr6:26056736 HIST1H1C 0.67 9.98 0.48 1.03e-20 Height; LUSC cis rs7177699 0.557 rs6495335 chr15:79117133 G/T cg00540400 chr15:79124168 NA 0.46 8.1 0.41 1.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs796825 0.530 rs55762220 chr3:119956606 T/C cg21790991 chr3:120137480 FSTL1 -0.34 -6.0 -0.31 5.02e-9 HIV-1 susceptibility; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg10150615 chr22:24372951 LOC391322 -0.37 -6.26 -0.32 1.2e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10876993 0.890 rs2619441 chr12:58083015 C/A cg15848620 chr12:58087721 OS9 -0.57 -8.08 -0.4 1.16e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05901451 chr6:126070800 HEY2 0.88 17.02 0.68 3.35e-47 Brugada syndrome; LUSC cis rs3774749 0.565 rs2518796 chr3:50207075 A/G cg24110177 chr3:50126178 RBM5 -0.39 -5.94 -0.31 7.04e-9 Intelligence (multi-trait analysis); LUSC cis rs6690583 0.524 rs12029690 chr1:85452867 C/G cg22153463 chr1:85462885 MCOLN2 0.62 6.0 0.31 5.12e-9 Serum sulfate level; LUSC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg05623727 chr3:50126028 RBM5 0.33 6.05 0.31 3.94e-9 Intelligence (multi-trait analysis); LUSC trans rs1997103 1.000 rs6966183 chr7:55407546 A/C cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.54e-11 Extrinsic epigenetic age acceleration; LUSC trans rs2262909 0.962 rs409835 chr19:22230671 T/C cg05197062 chr11:11642011 GALNTL4 -0.56 -7.81 -0.39 7.34e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.71 -0.3 2.45e-8 Depression; LUSC cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg04450456 chr4:17643702 FAM184B 0.36 6.15 0.32 2.2e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7131987 1.000 rs7131987 chr12:29406488 G/T cg09582351 chr12:29534625 ERGIC2 -0.3 -6.23 -0.32 1.38e-9 QT interval; LUSC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg07701084 chr6:150067640 NUP43 0.57 8.85 0.44 5.05e-17 Lung cancer; LUSC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg22029157 chr1:209979665 IRF6 0.74 8.76 0.43 9.93e-17 Coronary artery disease; LUSC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg02574844 chr11:5959923 NA 0.54 8.54 0.42 4.91e-16 DNA methylation (variation); LUSC cis rs11677416 1.000 rs17561 chr2:113537223 C/A cg27083787 chr2:113543245 IL1A 0.48 7.41 0.38 1.05e-12 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg04586622 chr2:25135609 ADCY3 0.42 8.98 0.44 1.97e-17 Body mass index; LUSC cis rs78572108 0.858 rs4952569 chr2:42263169 A/G cg00607755 chr2:42274082 PKDCC 0.36 6.49 0.33 3.05e-10 Total body bone mineral density; LUSC cis rs1878931 0.517 rs17685105 chr16:3413749 C/T cg22508957 chr16:3507546 NAT15 0.4 6.25 0.32 1.23e-9 Body mass index (adult); LUSC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg21699342 chr2:239360505 ASB1 0.53 9.92 0.48 1.75e-20 Multiple system atrophy; LUSC cis rs5758659 0.935 rs134879 chr22:42664201 A/C cg05082376 chr22:42548792 NA -0.39 -6.54 -0.34 2.34e-10 Cognitive function; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05725090 chr13:113242514 TUBGCP3 -0.45 -6.67 -0.34 1.03e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7681440 0.838 rs1348224 chr4:90761946 G/A cg01966878 chr4:90757139 SNCA -0.36 -6.21 -0.32 1.59e-9 Dementia with Lewy bodies; LUSC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg24675056 chr1:15929824 NA 0.43 7.56 0.38 3.85e-13 Systolic blood pressure; LUSC cis rs10504229 0.953 rs59034808 chr8:58185337 T/C cg22535103 chr8:58192502 C8orf71 -0.75 -9.55 -0.46 2.95e-19 Developmental language disorder (linguistic errors); LUSC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg02574844 chr11:5959923 NA -0.42 -6.63 -0.34 1.33e-10 DNA methylation (variation); LUSC cis rs12908161 0.853 rs11633788 chr15:85305142 T/A cg17507749 chr15:85114479 UBE2QP1 0.46 6.11 0.32 2.79e-9 Schizophrenia; LUSC cis rs9467773 1.000 rs9986382 chr6:26550619 T/C cg09904177 chr6:26538194 HMGN4 0.75 14.05 0.61 1.54e-35 Intelligence (multi-trait analysis); LUSC cis rs2425143 0.908 rs6060625 chr20:34414318 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -5.99 -0.31 5.43e-9 Blood protein levels; LUSC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.42 -0.33 4.59e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -8.53 -0.42 5.23e-16 Hemoglobin concentration; LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.88 -0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3617 0.573 rs9860296 chr3:52913781 A/G cg11645453 chr3:52864694 ITIH4 0.32 7.26 0.37 2.76e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg02018176 chr4:1364513 KIAA1530 0.46 7.97 0.4 2.47e-14 Obesity-related traits; LUSC trans rs7618501 0.633 rs35065728 chr3:50009176 T/C cg21659725 chr3:3221576 CRBN 0.61 9.98 0.48 1.08e-20 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC trans rs2262909 0.925 rs56073035 chr19:22276298 C/G cg17074339 chr11:11642133 GALNTL4 0.44 6.76 0.35 6.13e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg22166914 chr1:53195759 ZYG11B 0.5 7.88 0.4 4.68e-14 Monocyte count; LUSC cis rs62400317 0.762 rs12208605 chr6:44963735 A/C cg20913747 chr6:44695427 NA 0.47 7.15 0.36 5.42e-12 Total body bone mineral density; LUSC cis rs2985684 0.948 rs11623263 chr14:50083295 A/G cg04989706 chr14:50066350 PPIL5 -0.46 -5.88 -0.31 9.79e-9 Carotid intima media thickness; LUSC cis rs227584 0.663 rs2040810 chr17:42243771 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.32 -5.75 -0.3 2.05e-8 Bone mineral density (hip);Bone mineral density; LUSC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg12463550 chr7:65579703 CRCP 0.57 8.47 0.42 7.7e-16 Aortic root size; LUSC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11644478 chr21:40555479 PSMG1 0.93 18.29 0.71 2.88e-52 Cognitive function; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18128437 chr3:167453397 PDCD10;SERPINI1 0.46 6.73 0.35 7.32e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9487051 0.768 rs463503 chr6:109525757 T/C cg00509249 chr6:109615579 CCDC162 -0.33 -5.74 -0.3 2.15e-8 Reticulocyte fraction of red cells; LUSC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg23281280 chr6:28129359 ZNF389 0.49 6.47 0.33 3.51e-10 Parkinson's disease; LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg20607798 chr8:58055168 NA 0.55 6.09 0.32 3.07e-9 Developmental language disorder (linguistic errors); LUSC cis rs7843479 0.562 rs11774629 chr8:21859315 C/T cg17168535 chr8:21777572 XPO7 0.82 14.58 0.62 1.36e-37 Mean corpuscular volume; LUSC cis rs7578035 0.500 rs17021941 chr2:99384299 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -6.14 -0.32 2.31e-9 Bipolar disorder; LUSC cis rs7246657 0.714 rs12972195 chr19:37752505 T/C cg23950597 chr19:37808831 NA -0.62 -7.21 -0.37 3.67e-12 Coronary artery calcification; LUSC cis rs62027291 0.950 rs11637631 chr15:77283977 G/T cg26408565 chr15:76604113 ETFA 0.45 5.87 0.31 1.03e-8 Plateletcrit; LUSC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.41 8.47 0.42 8.14e-16 Hemoglobin concentration; LUSC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg08219700 chr8:58056026 NA 0.69 8.07 0.4 1.27e-14 Developmental language disorder (linguistic errors); LUSC cis rs7107174 0.688 rs10899501 chr11:78131408 C/T cg27205649 chr11:78285834 NARS2 -0.51 -5.87 -0.31 1.06e-8 Testicular germ cell tumor; LUSC cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg21385522 chr1:16154831 NA 0.52 7.81 0.39 7.48e-14 Systolic blood pressure; LUSC cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg05855489 chr10:104503620 C10orf26 0.52 8.03 0.4 1.67e-14 Arsenic metabolism; LUSC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs1814175 0.645 rs28436748 chr11:50046422 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs6582630 0.598 rs10880614 chr12:38509766 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.46 -0.33 3.65e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs79387448 0.745 rs723292 chr2:103166804 A/G cg09003973 chr2:102972529 NA 0.87 8.7 0.43 1.59e-16 Gut microbiota (bacterial taxa); LUSC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg19346786 chr7:2764209 NA -0.44 -7.58 -0.38 3.44e-13 Height; LUSC cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg26395211 chr5:140044315 WDR55 -0.38 -5.84 -0.3 1.27e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg17689763 chr4:710664 PCGF3 -0.63 -11.18 -0.52 7e-25 White blood cell count; LUSC cis rs752010 0.668 rs10890147 chr1:42089725 A/T cg06885757 chr1:42089581 HIVEP3 0.63 13.21 0.59 2.37e-32 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg04944784 chr2:26401820 FAM59B -0.68 -9.49 -0.46 4.49e-19 Gut microbiome composition (summer); LUSC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg24739457 chr1:205821442 NA 0.41 7.05 0.36 1.04e-11 Menarche (age at onset); LUSC cis rs3808502 0.516 rs6983727 chr8:11415812 A/G cg21175976 chr8:11421337 BLK 0.35 5.69 0.3 2.75e-8 Neuroticism; LUSC cis rs2070488 0.804 rs13092539 chr3:38458725 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 12.25 0.56 9.92e-29 Electrocardiographic conduction measures; LUSC cis rs6120849 0.707 rs6088703 chr20:33676049 T/A cg24642439 chr20:33292090 TP53INP2 0.57 6.34 0.33 7.31e-10 Protein C levels; LUSC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg27494647 chr7:150038898 RARRES2 0.51 7.92 0.4 3.67e-14 Blood protein levels;Circulating chemerin levels; LUSC trans rs330048 0.545 rs11781008 chr8:9153239 G/T cg06636001 chr8:8085503 FLJ10661 0.46 6.39 0.33 5.55e-10 Systemic lupus erythematosus; LUSC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg02951883 chr7:2050386 MAD1L1 -0.39 -6.49 -0.33 3.19e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7172677 1.000 rs11072525 chr15:75419110 G/A cg14664628 chr15:75095509 CSK -0.44 -5.77 -0.3 1.82e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs10256972 0.552 rs2949192 chr7:1203841 C/T cg13565492 chr6:43139072 SRF -0.41 -5.95 -0.31 6.8e-9 Longevity;Endometriosis; LUSC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -11.04 -0.52 2.2e-24 Bipolar disorder and schizophrenia; LUSC cis rs1577917 0.655 rs9444351 chr6:86247799 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 7.08 0.36 8.37e-12 Response to antipsychotic treatment; LUSC cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg08999081 chr20:33150536 PIGU -0.54 -10.65 -0.5 5.42e-23 Glomerular filtration rate (creatinine); LUSC trans rs1728785 0.818 rs11648503 chr16:68598938 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.65 8.38 0.42 1.46e-15 Ulcerative colitis; LUSC cis rs12410462 0.581 rs77837509 chr1:227559873 C/T cg10327440 chr1:227177885 CDC42BPA -0.63 -5.92 -0.31 8.15e-9 Major depressive disorder; LUSC cis rs2294693 0.945 rs68031000 chr6:41008841 G/T cg14769373 chr6:40998127 UNC5CL -0.54 -7.22 -0.37 3.59e-12 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs1801251 0.963 rs13011298 chr2:233612996 A/G cg25237894 chr2:233734115 C2orf82 0.34 6.33 0.33 7.67e-10 Coronary artery disease; LUSC trans rs12458462 0.892 rs12456692 chr18:77482189 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.48 -6.9 -0.35 2.67e-11 Monocyte count; LUSC cis rs6456156 0.586 rs1358883 chr6:167467433 C/G cg07741184 chr6:167504864 NA -0.39 -6.9 -0.35 2.69e-11 Primary biliary cholangitis; LUSC cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg00677455 chr12:58241039 CTDSP2 0.49 7.28 0.37 2.45e-12 Intelligence (multi-trait analysis); LUSC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg18252515 chr7:66147081 NA -1.23 -13.29 -0.59 1.17e-32 Diabetic kidney disease; LUSC cis rs73200209 0.744 rs11612443 chr12:116518839 A/G cg01776926 chr12:116560359 MED13L -0.49 -6.03 -0.31 4.4e-9 Total body bone mineral density; LUSC cis rs911119 0.913 rs13043610 chr20:23586941 G/A cg16589663 chr20:23618590 CST3 0.63 7.49 0.38 6.4e-13 Chronic kidney disease; LUSC cis rs75804782 0.641 rs112066551 chr2:239362486 G/A cg18131467 chr2:239335373 ASB1 -0.74 -6.67 -0.34 1.06e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg02569458 chr12:86230093 RASSF9 -0.45 -7.26 -0.37 2.69e-12 Major depressive disorder; LUSC cis rs7089973 0.604 rs35319791 chr10:116602296 C/A cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs8114671 0.562 rs4911164 chr20:33479488 G/C cg24642439 chr20:33292090 TP53INP2 0.45 6.5 0.34 2.84e-10 Height; LUSC cis rs35883536 0.647 rs2809790 chr1:101040461 C/T cg09408571 chr1:101003634 GPR88 0.29 5.84 0.3 1.25e-8 Monocyte count; LUSC cis rs7100689 0.577 rs756208 chr10:82041751 A/G cg01528321 chr10:82214614 TSPAN14 0.94 14.57 0.62 1.41e-37 Post bronchodilator FEV1; LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg12412775 chr1:25698385 RHCE -0.29 -5.87 -0.31 1.05e-8 Erythrocyte sedimentation rate; LUSC cis rs911555 0.755 rs55742283 chr14:103942965 A/G cg12935359 chr14:103987150 CKB 0.66 10.58 0.5 9.03e-23 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.77 0.47 5.18e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs7605378 1.000 rs796363 chr2:200693668 T/C cg23649088 chr2:200775458 C2orf69 0.52 8.15 0.41 7.55e-15 Osteoporosis; LUSC cis rs7923609 1.000 rs7070296 chr10:65070438 T/A cg01631684 chr10:65280961 REEP3 -0.43 -6.62 -0.34 1.39e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs7582720 0.806 rs72926770 chr2:203798585 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7246967 0.673 rs59621958 chr19:22940659 C/T cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg16322792 chr1:120165303 ZNF697 0.74 15.57 0.65 1.72e-41 Systemic lupus erythematosus; LUSC cis rs1783925 0.881 rs643446 chr11:125306472 T/C cg03464685 chr11:125439445 EI24 -0.46 -6.15 -0.32 2.22e-9 Formal thought disorder in schizophrenia; LUSC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.03 0.52 2.41e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg11366901 chr6:160182831 ACAT2 0.93 13.0 0.58 1.46e-31 Age-related macular degeneration (geographic atrophy); LUSC cis rs13082711 0.555 rs73038733 chr3:27263537 C/G cg02860705 chr3:27208620 NA 0.66 11.57 0.53 2.87e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs7174348 1 rs7174348 chr15:78792439 G/A cg24631222 chr15:78858424 CHRNA5 0.65 8.65 0.43 2.2e-16 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.16e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10782582 0.609 rs11588643 chr1:76255613 A/G cg10523679 chr1:76189770 ACADM -0.45 -6.51 -0.34 2.76e-10 Daytime sleep phenotypes; LUSC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.37e-21 Intelligence (multi-trait analysis); LUSC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg11871910 chr12:69753446 YEATS4 0.69 10.65 0.5 5.18e-23 Blood protein levels; LUSC cis rs7188861 0.768 rs1690500 chr16:11389986 C/T cg00044050 chr16:11439710 C16orf75 0.57 6.35 0.33 7.17e-10 HDL cholesterol; LUSC cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg03146154 chr1:46216737 IPP 0.55 8.25 0.41 3.82e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9807989 0.801 rs4851566 chr2:102972799 G/C cg03938978 chr2:103052716 IL18RAP 0.32 5.91 0.31 8.29e-9 Asthma; LUSC cis rs12195417 0.758 rs13197684 chr6:84132963 A/C cg08257003 chr6:84140564 ME1 0.37 9.11 0.45 7.7e-18 Schizophrenia; LUSC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg13560548 chr3:10150139 C3orf24 0.46 6.4 0.33 5.28e-10 Alzheimer's disease; LUSC cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs950027 0.549 rs9920634 chr15:45596546 G/T cg26924012 chr15:45694286 SPATA5L1 -0.75 -10.86 -0.51 9.72e-24 Response to fenofibrate (adiponectin levels); LUSC cis rs2108225 1.000 rs6466191 chr7:107453511 A/T cg18560240 chr7:107437656 SLC26A3 -0.38 -5.8 -0.3 1.51e-8 Ulcerative colitis; LUSC cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg24011408 chr12:48396354 COL2A1 -0.39 -5.69 -0.3 2.82e-8 Glycated hemoglobin levels; LUSC cis rs61931739 0.534 rs1608911 chr12:34010249 T/C cg06521331 chr12:34319734 NA -0.48 -7.67 -0.39 1.84e-13 Morning vs. evening chronotype; LUSC cis rs911555 0.662 rs4906322 chr14:103879032 A/G cg24130564 chr14:104152367 KLC1 0.45 6.42 0.33 4.8e-10 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC cis rs11098499 0.754 rs11098502 chr4:120252063 T/A cg09307838 chr4:120376055 NA 0.7 10.65 0.5 5.42e-23 Corneal astigmatism; LUSC cis rs500891 0.553 rs4706999 chr6:84168264 A/C cg08257003 chr6:84140564 ME1 0.36 8.74 0.43 1.17e-16 Platelet-derived growth factor BB levels; LUSC cis rs7605827 0.930 rs6725454 chr2:15692879 C/A cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs56399783 0.808 rs73049331 chr7:2799911 C/T cg19731401 chr7:2775893 GNA12 0.69 9.08 0.44 9.72e-18 Childhood ear infection; LUSC trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg03929089 chr4:120376271 NA -0.45 -6.26 -0.32 1.18e-9 Height; LUSC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg06484146 chr7:12443880 VWDE -0.6 -6.94 -0.36 2.04e-11 Coronary artery disease; LUSC cis rs7833787 0.965 rs7833694 chr8:18700346 T/C cg17701159 chr8:18705777 PSD3 -0.37 -6.01 -0.31 4.89e-9 Obesity-related traits; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg11235426 chr6:292522 DUSP22 -0.45 -6.7 -0.34 9.08e-11 Menopause (age at onset); LUSC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg17971929 chr21:40555470 PSMG1 0.79 13.89 0.61 6.06e-35 Cognitive function; LUSC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg00945038 chr17:61921165 SMARCD2 0.51 8.71 0.43 1.46e-16 Prudent dietary pattern; LUSC cis rs11190604 1.000 rs10883493 chr10:102208188 A/T cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.4 6.06 0.31 3.59e-9 Intelligence (multi-trait analysis); LUSC cis rs7149337 0.805 rs2999354 chr14:51607179 C/G cg23942311 chr14:51606299 NA 0.49 11.44 0.53 8.76e-26 Cancer; LUSC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.35e-22 Alzheimer's disease (late onset); LUSC cis rs6599077 0.950 rs6782134 chr3:40100692 G/T cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs9921338 0.923 rs7186455 chr16:11427748 A/G cg00044050 chr16:11439710 C16orf75 -0.49 -6.57 -0.34 1.93e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs6076065 0.683 rs2424557 chr20:23422159 C/G cg11657817 chr20:23433608 CST11 -0.38 -6.65 -0.34 1.2e-10 Facial morphology (factor 15, philtrum width); LUSC cis rs2439831 0.681 rs484029 chr15:43619560 T/C cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.11 0.64 1.18e-39 Lung cancer in ever smokers; LUSC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.2 -0.45 3.99e-18 Gut microbiome composition (summer); LUSC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg27266027 chr21:40555129 PSMG1 0.41 6.07 0.32 3.4e-9 Cognitive function; LUSC cis rs6504340 0.739 rs4793938 chr17:46665229 T/G cg09704116 chr17:46666958 LOC404266 -0.37 -5.73 -0.3 2.22e-8 Primary tooth development (number of teeth); LUSC cis rs10740039 0.516 rs2068044 chr10:62320437 A/C cg18175470 chr10:62150864 ANK3 -0.47 -6.97 -0.36 1.65e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg08355456 chr11:67383691 NA 0.38 7.17 0.37 4.86e-12 Mean corpuscular volume; LUSC trans rs4111 0.592 rs9845373 chr3:56108410 C/G cg26379258 chr6:111888446 TRAF3IP2 -0.42 -6.56 -0.34 2.08e-10 Sense of smell; LUSC cis rs6121246 0.567 rs6087701 chr20:30217708 A/C cg21427119 chr20:30132790 HM13 -0.43 -6.1 -0.32 3.01e-9 Mean corpuscular hemoglobin; LUSC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg05347473 chr6:146136440 FBXO30 0.5 8.36 0.42 1.77e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg00074818 chr8:8560427 CLDN23 0.59 9.92 0.48 1.71e-20 Obesity-related traits; LUSC cis rs55675132 0.620 rs1750391 chr1:115642847 A/G cg01522456 chr1:115632236 TSPAN2 0.46 6.34 0.33 7.43e-10 Schizophrenia; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg09763514 chr7:2298050 SNX8 -0.48 -6.4 -0.33 5.22e-10 Neuroticism; LUSC cis rs9341808 0.718 rs9448893 chr6:80837239 A/G cg08355045 chr6:80787529 NA 0.57 10.02 0.48 7.75e-21 Sitting height ratio; LUSC cis rs8017423 0.967 rs2277515 chr14:90723000 A/G cg04374321 chr14:90722782 PSMC1 0.75 12.08 0.55 4e-28 Mortality in heart failure; LUSC cis rs17685 0.558 rs60787921 chr7:75792844 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs12545109 0.879 rs1513317 chr8:57372966 C/G cg09654669 chr8:57350985 NA -0.57 -7.46 -0.38 7.7e-13 Obesity-related traits; LUSC cis rs35883536 0.611 rs61070860 chr1:101097628 G/A cg06223162 chr1:101003688 GPR88 0.36 6.32 0.33 8.51e-10 Monocyte count; LUSC cis rs1551570 0.766 rs55752217 chr19:10218434 C/T cg16327482 chr19:10226339 EIF3G 0.39 7.2 0.37 4.11e-12 Narcolepsy; LUSC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.7 0.47 9.47e-20 Eosinophil percentage of white cells; LUSC cis rs68170813 0.559 rs78404515 chr7:106909126 G/A cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.92e-20 Coronary artery disease; LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg10802521 chr3:52805072 NEK4 -0.48 -7.62 -0.38 2.69e-13 Electroencephalogram traits; LUSC cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg02527881 chr3:46936655 PTH1R 0.39 6.89 0.35 2.8e-11 Colorectal cancer; LUSC cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg24642439 chr20:33292090 TP53INP2 0.48 7.15 0.36 5.68e-12 Glomerular filtration rate (creatinine); LUSC cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.16 0.49 2.56e-21 Bladder cancer; LUSC cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg22681709 chr2:178499509 PDE11A -0.6 -11.81 -0.54 3.82e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6430585 0.528 rs75667274 chr2:136682486 C/T cg07169764 chr2:136633963 MCM6 1.15 16.52 0.67 3.25e-45 Corneal structure; LUSC cis rs4588572 0.643 rs6874309 chr5:77774498 A/T cg11547950 chr5:77652471 NA 0.55 7.95 0.4 2.99e-14 Triglycerides; LUSC cis rs7107174 1.000 rs10899454 chr11:77997513 T/C cg02023728 chr11:77925099 USP35 0.47 6.74 0.35 6.97e-11 Testicular germ cell tumor; LUSC cis rs13315871 0.929 rs13101057 chr3:58291467 A/G cg12435725 chr3:58293450 RPP14 -0.77 -7.45 -0.38 8.27e-13 Cholesterol, total; LUSC cis rs478304 0.651 rs10896038 chr11:65505528 G/C cg10518572 chr11:65560635 OVOL1 -0.26 -6.03 -0.31 4.29e-9 Acne (severe); LUSC cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg11102782 chr19:18549136 ISYNA1 -0.35 -6.63 -0.34 1.37e-10 Breast cancer; LUSC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.67 -0.39 1.94e-13 Height; LUSC cis rs4663866 0.908 rs35093813 chr2:239153765 T/A cg16914508 chr2:239161102 PER2 0.67 7.06 0.36 9.86e-12 Irritable bowel syndrome; LUSC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg12463550 chr7:65579703 CRCP 0.46 6.85 0.35 3.66e-11 Aortic root size; LUSC cis rs2580764 0.503 rs2972097 chr2:55267545 T/C cg09592903 chr2:55203963 RTN4 0.48 9.58 0.46 2.34e-19 Mean platelet volume; LUSC cis rs9921338 0.961 rs4780357 chr16:11370971 G/A cg00044050 chr16:11439710 C16orf75 -0.49 -6.66 -0.34 1.11e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC trans rs7726839 0.540 rs72705030 chr5:645562 C/T cg11887960 chr12:57824829 NA 0.53 6.66 0.34 1.13e-10 Obesity-related traits; LUSC cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg21545522 chr1:205238299 TMCC2 0.51 9.63 0.47 1.51e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9325144 0.624 rs10783330 chr12:39114084 A/G cg26384229 chr12:38710491 ALG10B -0.59 -9.35 -0.46 1.34e-18 Morning vs. evening chronotype; LUSC cis rs11190604 1.000 rs2295779 chr10:102296061 A/G cg16342193 chr10:102329863 NA -0.34 -6.27 -0.32 1.09e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.28 -0.32 1.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.94 0.7 7.29e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg01652190 chr22:50026171 C22orf34 -0.32 -6.62 -0.34 1.39e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2795502 0.882 rs3123754 chr10:43339011 G/A cg27426351 chr10:43362370 NA -0.43 -6.0 -0.31 5.26e-9 Blood protein levels; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg03697856 chr19:2096672 C19orf36;MOBKL2A 0.68 6.22 0.32 1.46e-9 Body mass index; LUSC cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg14061069 chr19:46274453 DMPK -0.53 -9.16 -0.45 5.23e-18 Coronary artery disease; LUSC trans rs11700980 0.551 rs2832019 chr21:30112207 A/G cg14791747 chr16:20752902 THUMPD1 0.57 6.24 0.32 1.3e-9 QRS complex (12-leadsum); LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg27535305 chr1:53392650 SCP2 -0.49 -9.55 -0.46 2.99e-19 Monocyte count; LUSC cis rs9549367 0.789 rs2025247 chr13:113882564 C/G cg00898013 chr13:113819073 PROZ -0.56 -7.91 -0.4 3.93e-14 Platelet distribution width; LUSC trans rs7618501 0.633 rs4688689 chr3:50035542 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.55 8.93 0.44 2.81e-17 Intelligence (multi-trait analysis); LUSC cis rs11997175 0.655 rs72630923 chr8:33662404 C/A ch.8.33884649F chr8:33765107 NA 0.39 5.95 0.31 6.83e-9 Body mass index; LUSC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg27432699 chr2:27873401 GPN1 -0.55 -8.31 -0.41 2.46e-15 Total body bone mineral density; LUSC cis rs887829 0.570 rs6736743 chr2:234595950 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -6.12 -0.32 2.56e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs8017423 0.967 rs55962513 chr14:90729460 C/G cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs4285028 0.747 rs77570895 chr3:121384565 C/T cg11130432 chr3:121712080 ILDR1 -0.61 -8.76 -0.43 1.02e-16 Multiple sclerosis; LUSC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg01657329 chr11:68192670 LRP5 0.47 7.65 0.39 2.14e-13 Total body bone mineral density; LUSC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg12463550 chr7:65579703 CRCP 0.41 5.93 0.31 7.38e-9 Calcium levels; LUSC cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg04827223 chr11:72435913 ARAP1 -0.88 -15.22 -0.64 4.31e-40 Body mass index; LUSC trans rs75804782 0.641 rs72983861 chr2:239326126 G/A cg01134436 chr17:81009848 B3GNTL1 0.67 6.38 0.33 5.87e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg22709100 chr7:91322751 NA -0.39 -5.68 -0.3 2.88e-8 Breast cancer; LUSC cis rs887829 0.569 rs6431628 chr2:234647478 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.29 -0.37 2.3e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg13047869 chr3:10149882 C3orf24 0.65 9.2 0.45 3.94e-18 Alzheimer's disease; LUSC cis rs939658 1.000 rs4778935 chr15:79453282 T/C cg17916960 chr15:79447300 NA 0.47 9.46 0.46 5.87e-19 Refractive error; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08843001 chr8:30891486 WRN;PURG 0.44 6.5 0.34 2.88e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg07677032 chr17:61819896 STRADA 0.54 9.06 0.44 1.15e-17 Prudent dietary pattern; LUSC cis rs9653442 0.527 rs13003982 chr2:100759078 T/C cg22139774 chr2:100720529 AFF3 -0.42 -7.14 -0.36 5.8e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg03806693 chr22:41940476 POLR3H -0.9 -12.72 -0.57 1.64e-30 Vitiligo; LUSC cis rs4499344 0.664 rs259284 chr19:33163262 T/C cg22980127 chr19:33182716 NUDT19 -0.43 -6.42 -0.33 4.72e-10 Mean platelet volume; LUSC cis rs62481355 0.680 rs9640842 chr7:127071463 C/T cg25922125 chr7:127225783 GCC1 -0.44 -6.22 -0.32 1.5e-9 Type 2 diabetes; LUSC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs6494488 0.500 rs55960029 chr15:65047080 G/A cg08069370 chr15:64387884 SNX1 -0.65 -5.91 -0.31 8.23e-9 Coronary artery disease; LUSC cis rs11758351 1.000 rs11758351 chr6:26203910 T/G cg01420254 chr6:26195488 NA 0.69 7.45 0.38 7.81e-13 Gout;Renal underexcretion gout; LUSC cis rs11229555 0.598 rs12276438 chr11:58185419 G/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs12478296 0.591 rs12468297 chr2:242996474 A/G cg01596870 chr19:55963115 NA -0.55 -7.61 -0.38 2.91e-13 Obesity-related traits; LUSC trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg27661571 chr11:113659931 NA -0.69 -7.94 -0.4 3.16e-14 Hip circumference adjusted for BMI; LUSC trans rs12439619 0.846 rs62012056 chr15:82539619 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.48 -6.36 -0.33 6.52e-10 Intelligence (multi-trait analysis); LUSC cis rs9886651 0.935 rs4524749 chr8:128805447 G/A cg07795030 chr8:128802207 NA -0.34 -6.03 -0.31 4.45e-9 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs8014204 0.604 rs12147862 chr14:75384471 C/T cg08847533 chr14:75593920 NEK9 -0.49 -7.01 -0.36 1.35e-11 Caffeine consumption; LUSC cis rs7408868 0.831 rs1548555 chr19:15278057 A/G cg14696996 chr19:15285081 NOTCH3 0.96 9.25 0.45 2.69e-18 Pulse pressure; LUSC cis rs4654899 0.897 rs1021077 chr1:21106016 A/G cg01072550 chr1:21505969 NA -0.49 -7.26 -0.37 2.7e-12 Superior frontal gyrus grey matter volume; LUSC trans rs7944735 0.767 rs1017875 chr11:47999218 C/T cg15704280 chr7:45808275 SEPT13 0.64 6.82 0.35 4.23e-11 Intraocular pressure; LUSC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg13395646 chr4:1353034 KIAA1530 -0.6 -9.54 -0.46 3e-19 Obesity-related traits; LUSC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg23093090 chr10:104574429 C10orf26 -0.45 -8.08 -0.4 1.19e-14 Arsenic metabolism; LUSC cis rs7296418 0.922 rs1790134 chr12:123697898 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.28 -0.32 1.06e-9 Platelet count; LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg15790184 chr11:494944 RNH1 0.6 6.24 0.32 1.29e-9 Body mass index; LUSC cis rs11583043 1.000 rs17100939 chr1:101443701 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.83 0.3 1.32e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.28 0.37 2.4e-12 Cognitive ability; LUSC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg13397359 chr6:42928475 GNMT 0.58 9.76 0.47 5.81e-20 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9902453 0.904 rs4375718 chr17:28363642 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -10.96 -0.51 4.56e-24 Coffee consumption (cups per day); LUSC cis rs7605827 0.930 rs3805106 chr2:15535863 C/G cg19274914 chr2:15703543 NA 0.43 8.85 0.44 5.34e-17 Educational attainment (years of education); LUSC cis rs72781680 0.898 rs79023848 chr2:24038174 C/A cg08917208 chr2:24149416 ATAD2B 0.96 10.07 0.48 5.08e-21 Lymphocyte counts; LUSC cis rs11105298 0.891 rs11105313 chr12:89923376 A/T cg00757033 chr12:89920650 WDR51B -0.56 -10.02 -0.48 7.54e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg03806693 chr22:41940476 POLR3H -1.05 -14.49 -0.62 2.84e-37 Vitiligo; LUSC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg21643547 chr1:205240462 TMCC2 -0.5 -9.27 -0.45 2.28e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs17401966 0.540 rs58014725 chr1:10474457 T/A cg19773385 chr1:10388646 KIF1B -0.41 -7.1 -0.36 7.74e-12 Hepatocellular carcinoma; LUSC trans rs4714291 0.832 rs1404002 chr6:40064600 C/T cg02267698 chr19:7991119 CTXN1 -0.58 -8.63 -0.43 2.53e-16 Strep throat; LUSC cis rs5769765 1.000 rs4597652 chr22:50270570 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC cis rs4253772 0.744 rs1134224 chr22:46633371 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.47 6.35 0.33 7.02e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg04944784 chr2:26401820 FAM59B -0.75 -11.21 -0.52 5.76e-25 Gut microbiome composition (summer); LUSC cis rs6121246 0.567 rs6120937 chr20:30219721 C/T cg13852791 chr20:30311386 BCL2L1 0.79 8.89 0.44 3.84e-17 Mean corpuscular hemoglobin; LUSC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs7833986 0.501 rs17815934 chr8:57038395 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.15 0.55 2.14e-28 Height; LUSC cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.34 0.49 6.24e-22 Schizophrenia; LUSC cis rs9807841 0.544 rs10407692 chr19:10770783 A/G cg17710535 chr19:10819994 QTRT1 0.41 6.89 0.35 2.75e-11 Inflammatory skin disease; LUSC cis rs4776059 0.761 rs61731670 chr15:52901283 T/C cg24008177 chr15:52972085 KIAA1370 -0.35 -6.13 -0.32 2.46e-9 Schizophrenia; LUSC cis rs425277 1.000 rs385039 chr1:2077409 C/T cg03732007 chr1:2071316 PRKCZ -0.48 -7.76 -0.39 1.08e-13 Height; LUSC cis rs9902453 1.000 rs6505158 chr17:28403348 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.74 -0.43 1.16e-16 Coffee consumption (cups per day); LUSC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.51 9.86 0.47 2.77e-20 Monocyte percentage of white cells; LUSC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.81 -0.3 1.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7246967 0.673 rs73020703 chr19:22844339 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs243505 0.767 rs243530 chr7:148412618 T/C cg09806900 chr7:148480153 CUL1 -0.5 -6.48 -0.33 3.22e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7945705 0.738 rs11042067 chr11:8815453 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.33 -6.78 -0.35 5.63e-11 Hemoglobin concentration; LUSC cis rs4909189 1.000 rs11764065 chr7:158135974 T/C cg23298862 chr7:158159286 PTPRN2 0.32 5.66 0.3 3.32e-8 Response to amphetamines; LUSC cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg00631329 chr6:26305371 NA -0.46 -9.11 -0.45 7.58e-18 Educational attainment; LUSC trans rs6502050 0.835 rs8065556 chr17:80091176 G/C cg07393940 chr7:158741817 NA 0.38 6.88 0.35 2.92e-11 Life satisfaction; LUSC cis rs9811920 0.838 rs12488245 chr3:99835254 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.42 6.11 0.32 2.77e-9 Axial length; LUSC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg04287289 chr16:89883240 FANCA 0.78 6.25 0.32 1.25e-9 Skin colour saturation; LUSC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg18681998 chr4:17616180 MED28 0.9 17.84 0.7 1.85e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg10011746 chr16:89865162 FANCA 0.39 6.2 0.32 1.71e-9 Vitiligo; LUSC cis rs7553864 0.636 rs7543740 chr1:87609026 C/T cg17420885 chr1:87600446 LOC339524 -0.5 -6.85 -0.35 3.63e-11 Smoking behavior; LUSC cis rs1448094 0.967 rs10863115 chr12:86332586 T/C cg18827107 chr12:86230957 RASSF9 -0.41 -5.96 -0.31 6.57e-9 Major depressive disorder; LUSC cis rs7177699 0.557 rs7165902 chr15:79115872 T/G cg15571903 chr15:79123663 NA 0.32 5.9 0.31 9.02e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1568889 0.941 rs35357280 chr11:28322745 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.6 7.05 0.36 1.02e-11 Bipolar disorder; LUSC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg12379764 chr21:47803548 PCNT 0.68 9.61 0.47 1.82e-19 Testicular germ cell tumor; LUSC cis rs611744 0.608 rs667742 chr8:109254003 T/C cg21045802 chr8:109455806 TTC35 0.43 6.57 0.34 1.92e-10 Dupuytren's disease; LUSC cis rs9611565 0.694 rs5758411 chr22:42079734 G/A cg17376030 chr22:41985996 PMM1 -0.43 -5.81 -0.3 1.45e-8 Vitiligo; LUSC cis rs6815814 0.861 rs11936050 chr4:38789524 C/T cg06935464 chr4:38784597 TLR10 0.45 5.74 0.3 2.1e-8 Breast cancer; LUSC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.55 0.34 2.23e-10 Age-related macular degeneration (geographic atrophy); LUSC cis rs1551570 0.755 rs11667630 chr19:10229297 A/C cg00593900 chr19:10206746 ANGPTL6 -0.34 -5.69 -0.3 2.82e-8 Narcolepsy; LUSC trans rs9393777 0.920 rs13196692 chr6:27379119 C/T cg01620082 chr3:125678407 NA -0.8 -7.13 -0.36 6.4e-12 Intelligence (multi-trait analysis); LUSC cis rs12220238 1.000 rs10824110 chr10:75968098 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.3 0.37 2.12e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs868036 0.718 rs4776982 chr15:68114974 C/T cg24579218 chr15:68104479 NA 0.39 6.76 0.35 6.06e-11 Restless legs syndrome; LUSC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg08704250 chr15:31115839 NA 0.59 9.41 0.46 8.34e-19 Huntington's disease progression; LUSC cis rs722599 0.961 rs2359239 chr14:75326771 C/T cg06637938 chr14:75390232 RPS6KL1 -0.48 -7.54 -0.38 4.36e-13 IgG glycosylation; LUSC cis rs644799 0.664 rs603625 chr11:95554283 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.84 13.8 0.6 1.34e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6964587 0.933 rs13230837 chr7:91779017 A/G cg22709100 chr7:91322751 NA 0.39 5.7 0.3 2.6e-8 Breast cancer; LUSC cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg17420585 chr12:42539391 GXYLT1 -0.37 -7.05 -0.36 1.04e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.5 0.5 1.73e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9921222 0.521 rs62032884 chr16:363415 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.41 6.18 0.32 1.84e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs2637266 1.000 rs7477433 chr10:78358116 C/T cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg06636001 chr8:8085503 FLJ10661 0.6 8.87 0.44 4.48e-17 Neuroticism; LUSC trans rs2392780 0.536 rs590574 chr8:128335715 A/G cg10195415 chr17:73887371 TRIM65 0.42 6.65 0.34 1.23e-10 Breast cancer (early onset); LUSC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg14541582 chr5:601475 NA -0.37 -5.8 -0.3 1.56e-8 Lung disease severity in cystic fibrosis; LUSC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg18876405 chr7:65276391 NA 0.55 8.82 0.43 6.59e-17 Aortic root size; LUSC cis rs6940638 0.688 rs9379960 chr6:27121325 A/C cg05738196 chr6:26577821 NA -0.46 -6.47 -0.33 3.49e-10 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.875 rs1788178 chr8:101332518 A/C cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg04369109 chr6:150039330 LATS1 -0.4 -5.78 -0.3 1.72e-8 Testicular germ cell tumor; LUSC cis rs1322512 0.523 rs1727058 chr6:152930711 G/A cg27316956 chr6:152958899 SYNE1 -0.38 -6.18 -0.32 1.82e-9 Tonometry; LUSC cis rs72781680 0.898 rs12619525 chr2:23999565 G/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg17385448 chr1:15911702 AGMAT 0.37 6.25 0.32 1.26e-9 Systolic blood pressure; LUSC cis rs7582180 0.701 rs4622752 chr2:100892018 A/G cg08017756 chr2:100939284 LONRF2 0.41 7.22 0.37 3.42e-12 Intelligence (multi-trait analysis); LUSC cis rs7659604 0.643 rs6838881 chr4:122663616 A/T cg06713675 chr4:122721982 EXOSC9 -0.47 -7.31 -0.37 2.02e-12 Type 2 diabetes; LUSC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg12963246 chr6:28129442 ZNF389 0.4 6.38 0.33 5.91e-10 Parkinson's disease; LUSC cis rs11031096 0.727 rs7940013 chr11:4138304 C/T cg18678763 chr11:4115507 RRM1 -0.51 -7.58 -0.38 3.34e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2274273 0.870 rs8013713 chr14:55841252 A/G cg04306507 chr14:55594613 LGALS3 -0.53 -11.73 -0.54 7.72e-27 Protein biomarker; LUSC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -7.06 -0.36 9.9e-12 Breast cancer; LUSC cis rs7119 0.667 rs907392 chr15:77903393 T/C cg27398640 chr15:77910606 LINGO1 0.38 8.86 0.44 4.7e-17 Type 2 diabetes; LUSC cis rs9311676 0.681 rs4681846 chr3:58332543 T/C cg13750441 chr3:58318267 PXK -0.31 -5.88 -0.31 1.01e-8 Systemic lupus erythematosus; LUSC cis rs9398803 0.865 rs9375441 chr6:126778600 G/A cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.9e-9 Male-pattern baldness; LUSC trans rs7824557 0.527 rs2736296 chr8:11234844 G/A cg15556689 chr8:8085844 FLJ10661 -0.49 -7.5 -0.38 5.71e-13 Retinal vascular caliber; LUSC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg16434002 chr17:42200994 HDAC5 -0.44 -6.11 -0.32 2.73e-9 Total body bone mineral density; LUSC cis rs1395 0.744 rs57881048 chr2:27474165 T/C cg23587288 chr2:27483067 SLC30A3 -0.29 -5.7 -0.3 2.61e-8 Blood metabolite levels; LUSC cis rs2933343 0.630 rs75824035 chr3:128652985 T/C cg11901034 chr3:128598214 ACAD9 -0.39 -6.1 -0.32 2.91e-9 IgG glycosylation; LUSC cis rs2073300 0.609 rs6132609 chr20:23400412 A/C cg09953122 chr20:23471693 CST8 -0.66 -5.73 -0.3 2.2e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg12011299 chr4:100065546 ADH4 -0.69 -10.52 -0.5 1.55e-22 Alcohol dependence; LUSC cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13126279 chr21:47581558 C21orf56 -0.55 -8.47 -0.42 8.16e-16 Testicular germ cell tumor; LUSC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg04850211 chr1:228464232 OBSCN -0.33 -6.17 -0.32 2.03e-9 Diastolic blood pressure; LUSC trans rs800082 0.698 rs800077 chr3:144349940 A/G cg24215973 chr2:240111563 HDAC4 -0.73 -10.84 -0.51 1.15e-23 Smoking behavior; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19429466 chr4:87515395 PTPN13 -0.52 -6.65 -0.34 1.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs921665 0.584 rs5019161 chr2:3174761 A/G cg16434511 chr2:3151078 NA -0.62 -6.65 -0.34 1.18e-10 World class endurance athleticism; LUSC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg09835421 chr16:68378352 PRMT7 -0.54 -6.09 -0.32 3.03e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7000551 0.606 rs3802199 chr8:22267385 A/G cg12081754 chr8:22256438 SLC39A14 0.94 14.61 0.62 9.9e-38 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC trans rs6256 0.929 rs56272325 chr11:13508857 C/G cg07728579 chr15:83475013 FSD2 -0.41 -6.0 -0.31 5.1e-9 Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel; LUSC cis rs34779708 1.000 rs12769189 chr10:35399668 A/G cg04310649 chr10:35416472 CREM -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1595825 0.838 rs6742343 chr2:198666752 C/T cg10547527 chr2:198650123 BOLL -0.5 -5.71 -0.3 2.49e-8 Ulcerative colitis; LUSC cis rs7520050 0.966 rs11810993 chr1:46478793 A/G cg06784218 chr1:46089804 CCDC17 -0.29 -5.69 -0.3 2.83e-8 Red blood cell count;Reticulocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25876186 chr17:77979405 TBC1D16 0.41 6.13 0.32 2.47e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg26043149 chr18:55253948 FECH 0.42 6.19 0.32 1.74e-9 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4953318 0.619 rs13406901 chr2:46363066 T/G cg12428440 chr2:46370979 PRKCE 0.46 7.74 0.39 1.19e-13 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs11122272 0.735 rs2474634 chr1:231487017 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.93 -0.48 1.53e-20 Hemoglobin concentration; LUSC cis rs7561273 0.586 rs116650625 chr2:24353212 C/G cg20701182 chr2:24300061 SF3B14 0.46 5.87 0.31 1.05e-8 Quantitative traits; LUSC cis rs56283067 0.887 rs12197593 chr6:44740895 C/T cg18551225 chr6:44695536 NA -0.48 -8.46 -0.42 8.24e-16 Total body bone mineral density; LUSC cis rs7771547 0.508 rs3798471 chr6:36499571 C/T cg07856975 chr6:36356162 ETV7 0.39 6.58 0.34 1.83e-10 Platelet distribution width; LUSC cis rs861020 0.630 rs599649 chr1:210003402 T/C cg05527609 chr1:210001259 C1orf107 0.71 10.12 0.48 3.62e-21 Orofacial clefts; LUSC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.3e-11 Monocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26603524 chr1:145713802 CD160 -0.41 -6.05 -0.31 3.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs62400317 0.859 rs1324536 chr6:45116261 C/T cg20913747 chr6:44695427 NA 0.41 6.5 0.33 2.99e-10 Total body bone mineral density; LUSC cis rs6570726 0.935 rs391820 chr6:145821284 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.78 0.35 5.5e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs877282 0.891 rs11253393 chr10:788824 G/T cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC trans rs61931739 0.517 rs12816423 chr12:34067736 G/A cg13010199 chr12:38710504 ALG10B 0.57 8.61 0.43 2.89e-16 Morning vs. evening chronotype; LUSC cis rs3087591 0.708 rs7406783 chr17:29689980 A/G cg24425628 chr17:29625626 OMG;NF1 0.47 6.98 0.36 1.57e-11 Hip circumference; LUSC cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.74 0.3 2.11e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1348850 0.526 rs4144278 chr2:178412378 C/T cg22681709 chr2:178499509 PDE11A -0.43 -6.2 -0.32 1.71e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 10.01 0.48 8.46e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs231513 0.906 rs75508812 chr17:42003397 G/A cg26893861 chr17:41843967 DUSP3 0.55 5.75 0.3 1.99e-8 Cognitive function; LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.52 -0.42 5.6e-16 Bipolar disorder; LUSC cis rs4919087 0.620 rs793515 chr10:98988469 A/C cg25902810 chr10:99078978 FRAT1 -0.46 -6.47 -0.33 3.47e-10 Monocyte count; LUSC cis rs2346177 0.542 rs1900591 chr2:46697968 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.59 -9.29 -0.45 2.05e-18 HDL cholesterol; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg17355835 chr15:40886331 CASC5 0.38 6.18 0.32 1.86e-9 Triglycerides; LUSC cis rs727505 1.000 rs67939974 chr7:124554364 C/T cg23710748 chr7:124431027 NA -0.42 -7.42 -0.38 9.76e-13 Lewy body disease; LUSC cis rs12310956 0.532 rs11608842 chr12:33951121 C/T cg06521331 chr12:34319734 NA -0.47 -7.79 -0.39 8.67e-14 Morning vs. evening chronotype; LUSC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg18904891 chr8:8559673 CLDN23 0.62 8.92 0.44 3.11e-17 Obesity-related traits; LUSC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg07952391 chr2:88470173 THNSL2 0.77 6.84 0.35 3.74e-11 Plasma clusterin levels; LUSC cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg04450456 chr4:17643702 FAM184B -0.39 -6.6 -0.34 1.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11098499 0.708 rs10005237 chr4:120237897 T/C cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs981844 0.857 rs41320045 chr4:154720615 A/T cg14289246 chr4:154710475 SFRP2 -0.45 -5.74 -0.3 2.12e-8 Response to statins (LDL cholesterol change); LUSC cis rs7216064 1.000 rs34872586 chr17:65863466 T/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs6500395 0.775 rs11640119 chr16:48662840 C/T cg04672837 chr16:48644449 N4BP1 0.46 6.89 0.35 2.71e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg22709100 chr7:91322751 NA 0.4 5.81 0.3 1.48e-8 Breast cancer; LUSC cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg22920501 chr2:26401640 FAM59B 0.76 10.13 0.48 3.25e-21 Gut microbiome composition (summer); LUSC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.53 -8.94 -0.44 2.7e-17 Bipolar disorder; LUSC cis rs35883536 0.647 rs12046413 chr1:101047430 T/C cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC trans rs11098499 0.954 rs35091806 chr4:120325529 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.65 -13.71 -0.6 2.98e-34 Monocyte percentage of white cells; LUSC cis rs796364 0.806 rs56216998 chr2:200944333 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -8.2 -0.41 5.32e-15 Schizophrenia; LUSC trans rs877282 0.898 rs10904547 chr10:766283 C/T cg13042288 chr15:90349979 ANPEP -0.47 -6.4 -0.33 5.37e-10 Uric acid levels; LUSC cis rs2290159 0.800 rs5746214 chr3:12644753 A/G cg23032965 chr3:12705835 RAF1 0.74 8.96 0.44 2.42e-17 Cholesterol, total; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11238505 chr8:145691776 CYHR1;KIFC2 0.44 6.27 0.32 1.11e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg18451016 chr1:38461880 NA 0.58 10.36 0.49 5.32e-22 Coronary artery disease; LUSC cis rs7177699 0.581 rs7165081 chr15:79123396 C/G cg00540400 chr15:79124168 NA 0.43 7.51 0.38 5.44e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.38 0.49 4.76e-22 Schizophrenia; LUSC cis rs10193935 0.901 rs13384885 chr2:42536646 G/C cg27598129 chr2:42591480 NA -0.6 -8.17 -0.41 6.36e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg14552801 chr7:65878734 NA -0.43 -5.95 -0.31 6.61e-9 Aortic root size; LUSC cis rs1775715 0.870 rs1755072 chr10:32266642 A/G cg18675610 chr10:32216311 ARHGAP12 -0.29 -6.06 -0.31 3.64e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6964587 0.782 rs13221571 chr7:91500236 C/T cg17063962 chr7:91808500 NA -0.51 -7.87 -0.4 5.07e-14 Breast cancer; LUSC cis rs12200560 0.505 rs211176 chr6:97073821 G/A cg06623918 chr6:96969491 KIAA0776 0.51 7.33 0.37 1.78e-12 Coronary heart disease; LUSC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg22823121 chr1:150693482 HORMAD1 0.59 9.14 0.45 6.13e-18 Tonsillectomy; LUSC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.03e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg26384229 chr12:38710491 ALG10B 0.91 15.54 0.65 2.38e-41 Bladder cancer; LUSC cis rs2806561 0.765 rs643492 chr1:23501354 C/T cg19743168 chr1:23544995 NA -0.41 -7.94 -0.4 3.01e-14 Height; LUSC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg04518342 chr5:131593106 PDLIM4 -0.45 -7.7 -0.39 1.56e-13 Breast cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17728987 chr19:36485959 SDHAF1 -0.42 -6.1 -0.32 2.98e-9 Electrocardiographic conduction measures; LUSC cis rs2230307 0.536 rs7518943 chr1:100463422 G/T cg24955406 chr1:100503596 HIAT1 0.62 6.75 0.35 6.53e-11 Carotid intima media thickness; LUSC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.69 -10.94 -0.51 5.17e-24 Menarche (age at onset); LUSC cis rs8058578 0.887 rs28421305 chr16:30838128 G/A cg02466173 chr16:30829666 NA -0.58 -10.78 -0.51 1.9e-23 Multiple myeloma; LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg22535103 chr8:58192502 C8orf71 -0.65 -7.35 -0.37 1.55e-12 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg14552801 chr7:65878734 NA -0.44 -6.22 -0.32 1.51e-9 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03330254 chr5:108745575 PJA2 -0.4 -6.09 -0.32 3.04e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs11088226 0.681 rs1134747 chr21:33939011 T/A cg09050820 chr6:167586206 TCP10L2 0.73 9.47 0.46 5.31e-19 Gastritis; LUSC cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.98 0.72 5.41e-55 Chronic sinus infection; LUSC cis rs9469578 1.000 rs73743323 chr6:33705355 C/T cg18708504 chr6:33715942 IP6K3 0.73 9.03 0.44 1.38e-17 Phosphorus levels; LUSC cis rs16976116 0.951 rs13733 chr15:55489104 A/G cg11288833 chr15:55489084 RSL24D1 0.54 6.56 0.34 2.04e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg21138405 chr5:131827807 IRF1 0.56 11.17 0.52 7.79e-25 Asthma (sex interaction); LUSC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg24846343 chr22:24311635 DDTL 0.77 17.41 0.69 9.54e-49 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg18681998 chr4:17616180 MED28 -0.86 -15.18 -0.64 5.77e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs454953 0.533 rs211436 chr6:133612992 A/G cg15729404 chr6:133561614 EYA4 -0.4 -5.83 -0.3 1.33e-8 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg00933542 chr6:150070202 PCMT1 0.32 6.61 0.34 1.55e-10 Lung cancer; LUSC cis rs9457247 0.765 rs3752520 chr6:167436159 T/C cg07741184 chr6:167504864 NA 0.42 7.5 0.38 5.69e-13 Crohn's disease; LUSC cis rs9916302 0.706 rs4287601 chr17:37513852 T/C cg07936489 chr17:37558343 FBXL20 0.8 9.91 0.48 1.86e-20 Glomerular filtration rate (creatinine); LUSC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.45 0.38 8.3e-13 Bipolar disorder; LUSC cis rs868036 1.000 rs1471460 chr15:68089299 G/A cg08079166 chr15:68083412 MAP2K5 0.4 8.42 0.42 1.13e-15 Restless legs syndrome; LUSC cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg26384229 chr12:38710491 ALG10B 0.87 14.22 0.61 3.36e-36 Bladder cancer; LUSC cis rs1997103 1.000 rs4948012 chr7:55412578 A/C cg17469321 chr7:55412551 NA 0.65 10.53 0.5 1.45e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs4776059 0.761 rs61731670 chr15:52901283 T/C cg25063058 chr15:52860530 ARPP19 -0.48 -5.97 -0.31 5.95e-9 Schizophrenia; LUSC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg25319279 chr11:5960081 NA -0.39 -6.22 -0.32 1.5e-9 DNA methylation (variation); LUSC cis rs61931739 0.500 rs11519398 chr12:34473553 C/T cg06521331 chr12:34319734 NA -0.41 -6.36 -0.33 6.67e-10 Morning vs. evening chronotype; LUSC cis rs8032315 1.000 rs2071410 chr15:91420940 C/G cg04510874 chr15:91427884 FES 0.32 6.24 0.32 1.32e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs981844 0.683 rs1563462 chr4:154755051 G/A cg14289246 chr4:154710475 SFRP2 -0.47 -6.54 -0.34 2.25e-10 Response to statins (LDL cholesterol change); LUSC cis rs7945705 0.776 rs11042069 chr11:8817315 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.34 6.61 0.34 1.55e-10 Hemoglobin concentration; LUSC cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg05347473 chr6:146136440 FBXO30 0.42 7.22 0.37 3.47e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg06544989 chr22:39130855 UNC84B 0.37 6.41 0.33 4.91e-10 Menopause (age at onset); LUSC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg09509183 chr1:209979624 IRF6 -0.5 -5.94 -0.31 7.25e-9 Cleft lip with or without cleft palate; LUSC cis rs34638657 0.872 rs2967349 chr16:82194405 G/C cg09439754 chr16:82129088 HSD17B2 -0.4 -6.23 -0.32 1.37e-9 Lung adenocarcinoma; LUSC trans rs10432489 0.708 rs11687566 chr2:181744418 T/C cg00055848 chr2:62422984 B3GNT2 -0.93 -6.12 -0.32 2.67e-9 QT interval; LUSC trans rs11098499 0.908 rs28499576 chr4:120386677 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.37e-9 Corneal astigmatism; LUSC cis rs12318506 0.826 rs11180431 chr12:75661200 G/A cg04728562 chr12:75699417 CAPS2 -0.77 -5.93 -0.31 7.49e-9 Coronary artery calcification; LUSC cis rs6484504 0.512 rs2774402 chr11:31312897 G/C cg14844989 chr11:31128820 NA 0.37 5.79 0.3 1.59e-8 Red blood cell count; LUSC cis rs2011503 0.597 rs8103992 chr19:19665643 A/C cg11244672 chr19:19639970 YJEFN3 0.46 6.12 0.32 2.69e-9 Bipolar disorder; LUSC cis rs7647973 1.000 rs11719762 chr3:49409002 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.97 0.36 1.73e-11 Menarche (age at onset); LUSC cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg27446573 chr6:127587934 RNF146 0.66 10.01 0.48 8.54e-21 Breast cancer; LUSC cis rs34779708 0.966 rs11010095 chr10:35395948 A/G cg03585969 chr10:35415529 CREM 0.6 8.85 0.44 5.36e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10979 1.000 rs9376761 chr6:143887165 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.01 -0.55 7.28e-28 Hypospadias; LUSC cis rs12989701 0.825 rs4663096 chr2:127861766 T/A cg08168897 chr2:127865431 BIN1 0.59 7.84 0.39 6.11e-14 Alzheimer's disease (late onset); LUSC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11890956 chr21:40555474 PSMG1 1.0 18.46 0.71 6.32e-53 Cognitive function; LUSC cis rs228769 0.562 rs228779 chr17:42091213 A/G cg19774624 chr17:42201019 HDAC5 0.63 6.99 0.36 1.48e-11 Bone mineral density (hip);Bone mineral density (spine); LUSC cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg24642439 chr20:33292090 TP53INP2 0.52 7.95 0.4 2.9e-14 Coronary artery disease; LUSC cis rs7654585 0.645 rs1123943 chr4:25924426 A/G cg10409131 chr4:25915609 C4orf52 -0.57 -7.57 -0.38 3.56e-13 Obesity-related traits; LUSC cis rs11122272 0.735 rs2749714 chr1:231538634 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.66 -10.3 -0.49 8.6e-22 Hemoglobin concentration; LUSC cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg26597838 chr10:835615 NA -0.48 -6.53 -0.34 2.45e-10 Response to angiotensin II receptor blocker therapy; LUSC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.4 7.71 0.39 1.46e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg26314531 chr2:26401878 FAM59B -0.66 -9.13 -0.45 6.46e-18 Gut microbiome composition (summer); LUSC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg26335602 chr6:28129616 ZNF389 0.42 5.74 0.3 2.08e-8 Parkinson's disease; LUSC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg23835219 chr4:1244017 CTBP1;C4orf42 0.31 5.8 0.3 1.52e-8 Obesity-related traits; LUSC cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg14061069 chr19:46274453 DMPK -0.54 -9.29 -0.45 2.09e-18 Coronary artery disease; LUSC cis rs62400317 0.826 rs17209769 chr6:45321205 C/A cg20913747 chr6:44695427 NA -0.47 -7.73 -0.39 1.24e-13 Total body bone mineral density; LUSC cis rs2836633 0.929 rs62217518 chr21:40033189 T/G cg05519781 chr21:40033154 ERG 0.77 13.32 0.59 9.59e-33 Coronary artery disease; LUSC cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg11645453 chr3:52864694 ITIH4 0.56 13.64 0.6 5.57e-34 Schizophrenia; LUSC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg27572855 chr1:25598939 RHD 0.41 7.15 0.36 5.55e-12 Erythrocyte sedimentation rate; LUSC cis rs4474465 0.562 rs10793318 chr11:78215898 A/C cg27205649 chr11:78285834 NARS2 0.52 6.0 0.31 5.01e-9 Alzheimer's disease (survival time); LUSC cis rs4820539 1.000 rs5759596 chr22:23475750 G/A cg21100191 chr22:23484243 RTDR1 0.92 16.29 0.67 2.57e-44 Bone mineral density; LUSC cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg01657329 chr11:68192670 LRP5 -0.41 -5.88 -0.31 1.02e-8 Total body bone mineral density; LUSC cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg13256891 chr4:100009986 ADH5 -0.42 -5.69 -0.3 2.74e-8 Alcohol dependence; LUSC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg05623727 chr3:50126028 RBM5 -0.35 -6.41 -0.33 5.1e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg20607798 chr8:58055168 NA 0.53 5.83 0.3 1.29e-8 Developmental language disorder (linguistic errors); LUSC cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg09184832 chr6:79620586 NA -0.42 -6.52 -0.34 2.58e-10 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.47 0.38 7.16e-13 Motion sickness; LUSC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.55 -8.42 -0.42 1.12e-15 Lymphocyte counts; LUSC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg12560992 chr17:57184187 TRIM37 0.83 15.26 0.64 2.95e-40 Intelligence (multi-trait analysis); LUSC cis rs7264396 0.563 rs2425084 chr20:34301871 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -8.77 -0.43 9.62e-17 Total cholesterol levels; LUSC cis rs4776059 1.000 rs4776058 chr15:52880263 A/G cg25063058 chr15:52860530 ARPP19 0.47 6.53 0.34 2.48e-10 Schizophrenia; LUSC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg11645453 chr3:52864694 ITIH4 -0.33 -7.93 -0.4 3.35e-14 Electroencephalogram traits; LUSC cis rs34779708 0.931 rs12767414 chr10:35390193 C/T cg03585969 chr10:35415529 CREM 0.59 8.81 0.43 7.18e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8060686 0.545 rs78229587 chr16:68165243 T/C cg27539214 chr16:67997921 SLC12A4 -0.59 -7.21 -0.37 3.87e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg12963246 chr6:28129442 ZNF389 0.53 7.41 0.38 1.04e-12 Parkinson's disease; LUSC cis rs9372253 1.000 rs7740028 chr6:110719180 A/G cg01119278 chr6:110721349 DDO -0.49 -8.76 -0.43 9.88e-17 Platelet distribution width; LUSC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg06221963 chr1:154839813 KCNN3 -0.65 -15.52 -0.65 2.78e-41 Prostate cancer; LUSC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg11366901 chr6:160182831 ACAT2 0.9 12.21 0.56 1.35e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs12950390 0.853 rs17700008 chr17:45863591 A/C cg03474202 chr17:45855739 NA 0.29 7.18 0.37 4.62e-12 IgG glycosylation; LUSC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.63 9.0 0.44 1.79e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9549260 0.604 rs56302456 chr13:41295887 G/T cg21288729 chr13:41239152 FOXO1 0.57 6.35 0.33 6.84e-10 Red blood cell count; LUSC cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg23158103 chr7:148848205 ZNF398 -0.5 -8.06 -0.4 1.38e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9894429 0.608 rs8477 chr17:79618059 C/T cg18240062 chr17:79603768 NPLOC4 0.6 10.25 0.49 1.32e-21 Eye color traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16779626 chr15:41709933 RTF1 0.41 6.04 0.31 4.07e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11828289 0.660 rs12099049 chr11:23219311 A/G cg20040320 chr11:23191996 NA -0.61 -6.33 -0.33 7.8e-10 Cancer; LUSC cis rs62103177 0.608 rs34383580 chr18:77833263 A/G cg20368463 chr18:77673604 PQLC1 -0.62 -6.64 -0.34 1.29e-10 Opioid sensitivity; LUSC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg16928487 chr17:17741425 SREBF1 0.34 6.42 0.33 4.77e-10 Total body bone mineral density; LUSC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00934597 chr7:893267 UNC84A -0.48 -7.1 -0.36 7.78e-12 Perceived unattractiveness to mosquitoes; LUSC cis rs4363385 0.747 rs2339493 chr1:152975277 G/A cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC cis rs13315871 0.929 rs9857333 chr3:58293551 G/C cg20936604 chr3:58311152 NA -0.67 -6.59 -0.34 1.69e-10 Cholesterol, total; LUSC cis rs7215564 0.908 rs35584560 chr17:78668256 G/A cg09596252 chr17:78655493 RPTOR 0.52 5.67 0.3 3.1e-8 Myopia (pathological); LUSC cis rs9467773 0.869 rs9295689 chr6:26455811 T/C cg11502198 chr6:26597334 ABT1 0.53 7.81 0.39 7.66e-14 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg03929089 chr4:120376271 NA -0.95 -16.55 -0.67 2.37e-45 Height; LUSC cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg08807101 chr21:30365312 RNF160 -0.76 -13.6 -0.6 7.84e-34 Dental caries; LUSC cis rs7590368 0.715 rs12471725 chr2:10958119 C/T cg15705551 chr2:10952987 PDIA6 0.61 6.1 0.32 3e-9 Educational attainment (years of education); LUSC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg24250549 chr1:154909240 PMVK 0.59 9.53 0.46 3.24e-19 Prostate cancer; LUSC cis rs977987 0.806 rs4888391 chr16:75400746 C/T cg03315344 chr16:75512273 CHST6 0.49 9.33 0.45 1.48e-18 Dupuytren's disease; LUSC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs1005224 0.927 rs1981899 chr14:76175594 G/A cg04684003 chr14:76127793 TTLL5;C14orf1 -0.59 -8.1 -0.41 1.07e-14 Large artery stroke; LUSC cis rs2073300 0.609 rs6137910 chr20:23346515 C/G cg09953122 chr20:23471693 CST8 -0.67 -5.72 -0.3 2.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1018836 0.608 rs12679836 chr8:91465287 A/G cg16814680 chr8:91681699 NA -0.53 -7.75 -0.39 1.11e-13 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.51 -6.49 -0.33 3.1e-10 Multiple sclerosis; LUSC cis rs752010 0.644 rs7541348 chr1:42113215 T/G cg06885757 chr1:42089581 HIVEP3 0.49 9.75 0.47 6.37e-20 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs2219968 1.000 rs13266678 chr8:78958272 T/C cg00738934 chr8:78996279 NA 0.37 6.76 0.35 6.13e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs2297440 0.527 rs4809318 chr20:62264760 G/A cg06363034 chr20:62225388 GMEB2 -0.46 -7.73 -0.39 1.24e-13 Glioma;Non-glioblastoma glioma;Glioblastoma; LUSC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg16797656 chr11:68205561 LRP5 0.39 7.14 0.36 5.87e-12 Total body bone mineral density; LUSC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg09640425 chr7:158790006 NA -0.44 -6.97 -0.36 1.69e-11 Facial morphology (factor 20); LUSC cis rs11039100 1.000 rs4319539 chr11:5828846 T/A cg13902645 chr11:5959945 NA -0.52 -5.83 -0.3 1.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg12463550 chr7:65579703 CRCP 0.45 6.76 0.35 6.2e-11 Aortic root size; LUSC cis rs7759001 0.857 rs10080558 chr6:27362898 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs4555082 1.000 rs7146012 chr14:105757566 G/A cg06808227 chr14:105710500 BRF1 -0.63 -9.62 -0.47 1.67e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs10744422 1.000 rs921808 chr12:123323135 A/G cg25930673 chr12:123319894 HIP1R 0.63 6.23 0.32 1.41e-9 Schizophrenia; LUSC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg24531977 chr5:56204891 C5orf35 -0.59 -8.9 -0.44 3.73e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs62400317 0.762 rs529125 chr6:44797088 C/T cg18551225 chr6:44695536 NA 0.44 7.15 0.36 5.48e-12 Total body bone mineral density; LUSC trans rs637571 0.510 rs10750772 chr11:65577427 C/T cg17712092 chr4:129076599 LARP1B -0.71 -10.28 -0.49 1.02e-21 Eosinophil percentage of white cells; LUSC cis rs10883723 0.962 rs10883726 chr10:104236276 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.4 -0.38 1.1e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2839186 0.967 rs2839191 chr21:47695395 C/G cg11766577 chr21:47581405 C21orf56 -0.43 -6.44 -0.33 4.23e-10 Testicular germ cell tumor; LUSC cis rs7000551 0.646 rs2979302 chr8:22359156 G/A cg12081754 chr8:22256438 SLC39A14 0.47 7.1 0.36 7.72e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.3 0.41 2.67e-15 Prudent dietary pattern; LUSC cis rs713587 0.967 rs6752378 chr2:25150116 C/A cg01884057 chr2:25150051 NA 0.5 11.91 0.55 1.66e-27 Body mass index in non-asthmatics; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08149078 chr3:128369362 RPN1 -0.41 -6.09 -0.32 3.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg10523679 chr1:76189770 ACADM 0.9 16.53 0.67 2.86e-45 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11644478 chr21:40555479 PSMG1 0.94 18.94 0.72 7.18e-55 Cognitive function; LUSC cis rs4285028 0.898 rs73855476 chr3:121633412 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.76 -10.16 -0.49 2.68e-21 Multiple sclerosis; LUSC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg11062466 chr8:58055876 NA 0.66 8.67 0.43 1.93e-16 Developmental language disorder (linguistic errors); LUSC cis rs57590327 0.503 rs9852235 chr3:81508355 A/G cg07356753 chr3:81810745 GBE1 0.46 6.17 0.32 1.96e-9 Extraversion; LUSC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.57 -0.34 1.94e-10 Schizophrenia; LUSC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg16262614 chr3:133464971 TF 0.44 7.65 0.39 2.13e-13 Iron status biomarkers (transferrin levels); LUSC cis rs7582720 1.000 rs72934545 chr2:203975958 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.61 0.43 2.86e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs11676348 0.772 rs6738953 chr2:218950036 C/A cg06547715 chr2:218990976 CXCR2 0.31 6.01 0.31 4.97e-9 Ulcerative colitis; LUSC cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg10207240 chr12:122356781 WDR66 -0.42 -5.96 -0.31 6.38e-9 Mean corpuscular volume; LUSC cis rs9487051 0.803 rs410449 chr6:109539853 C/T cg00509249 chr6:109615579 CCDC162 -0.34 -5.82 -0.3 1.38e-8 Reticulocyte fraction of red cells; LUSC cis rs8036030 0.691 rs11852760 chr15:74718699 A/G cg14664628 chr15:75095509 CSK -0.49 -7.3 -0.37 2.18e-12 Airflow obstruction; LUSC cis rs854765 0.583 rs5002487 chr17:17832460 A/G cg09796270 chr17:17721594 SREBF1 0.44 7.89 0.4 4.42e-14 Total body bone mineral density; LUSC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.96 -0.36 1.84e-11 Aortic root size; LUSC trans rs7937682 0.889 rs479667 chr11:111484034 C/T cg18187862 chr3:45730750 SACM1L 0.54 7.09 0.36 8.05e-12 Primary sclerosing cholangitis; LUSC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg22800045 chr5:56110881 MAP3K1 0.68 8.06 0.4 1.36e-14 Initial pursuit acceleration; LUSC cis rs7824557 0.767 rs7003241 chr8:11169075 A/G cg21293242 chr8:11204541 TDH 0.31 5.87 0.31 1.04e-8 Retinal vascular caliber; LUSC cis rs7123876 0.587 rs11602616 chr11:72364077 T/C cg04827223 chr11:72435913 ARAP1 -0.61 -7.18 -0.37 4.59e-12 Body mass index; LUSC cis rs965513 1.000 rs7850258 chr9:100549013 C/T cg13688889 chr9:100608707 NA 0.56 8.61 0.43 2.95e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs9902453 0.967 rs1906451 chr17:28515479 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.38 0.42 1.47e-15 Coffee consumption (cups per day); LUSC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg09655341 chr17:79618100 PDE6G -0.27 -6.26 -0.32 1.16e-9 Eye color traits; LUSC trans rs2055729 0.885 rs13268133 chr8:9731470 C/T cg15556689 chr8:8085844 FLJ10661 0.48 6.58 0.34 1.82e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs73110464 0.609 rs6580923 chr12:53358352 A/G cg14581129 chr12:53358946 NA -0.69 -9.31 -0.45 1.72e-18 Cancer (pleiotropy); LUSC cis rs35995292 0.963 rs10239557 chr7:38950137 C/T cg19327137 chr7:38886074 VPS41 0.37 6.05 0.31 3.81e-9 Subjective well-being (multi-trait analysis); LUSC cis rs9325144 0.600 rs7965877 chr12:38743697 G/T cg26384229 chr12:38710491 ALG10B 0.6 9.51 0.46 3.96e-19 Morning vs. evening chronotype; LUSC cis rs4253772 0.872 rs79700435 chr22:46638211 G/A cg18190219 chr22:46762943 CELSR1 -0.48 -5.73 -0.3 2.3e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -7.95 -0.4 2.95e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9902453 0.808 rs62068617 chr17:28144728 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.32 0.45 1.6e-18 Coffee consumption (cups per day); LUSC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs6901250 0.655 rs1398404 chr6:117126345 A/C cg12892004 chr6:117198278 RFX6 0.4 7.59 0.38 3.22e-13 C-reactive protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00412273 chr17:38296476 CASC3 0.43 6.07 0.32 3.56e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2219968 0.962 rs9643732 chr8:78946230 G/A cg00738934 chr8:78996279 NA 0.37 6.63 0.34 1.3100000000000001e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs4409675 0.576 rs10751725 chr1:28216191 A/C cg23691781 chr1:28212827 C1orf38 -0.32 -7.55 -0.38 4.07e-13 Corneal astigmatism; LUSC cis rs9359856 0.529 rs56352205 chr6:90439272 C/T cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.43 -0.42 1.02e-15 Bipolar disorder; LUSC cis rs6542838 0.702 rs6419564 chr2:99534113 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -6.17 -0.32 1.93e-9 Fear of minor pain; LUSC trans rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05039488 chr6:79577232 IRAK1BP1 0.47 7.33 0.37 1.71e-12 Endometrial cancer; LUSC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg17507749 chr15:85114479 UBE2QP1 0.68 8.55 0.42 4.36e-16 Schizophrenia; LUSC cis rs6430585 0.527 rs1900306 chr2:136416533 G/A cg07169764 chr2:136633963 MCM6 1.1 14.73 0.63 3.42e-38 Corneal structure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11381792 chr21:45432451 TRAPPC10 0.51 8.77 0.43 9.18e-17 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg17143192 chr8:8559678 CLDN23 0.63 8.89 0.44 3.88e-17 Obesity-related traits; LUSC cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg00277334 chr10:82204260 NA -0.93 -19.24 -0.73 4.86e-56 Post bronchodilator FEV1; LUSC cis rs1256061 0.646 rs1256056 chr14:64712626 A/G cg23250157 chr14:64679961 SYNE2 0.33 6.06 0.31 3.6e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs1018836 0.851 rs6986359 chr8:91643162 A/G cg16814680 chr8:91681699 NA -0.79 -13.16 -0.58 3.71e-32 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1506636 1.000 rs12333705 chr7:123356062 C/T cg03229431 chr7:123269106 ASB15 -0.64 -10.57 -0.5 1.05e-22 Plateletcrit;Platelet count; LUSC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg03676636 chr4:99064102 C4orf37 0.27 5.78 0.3 1.68e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs4900538 0.855 rs762105 chr14:102830175 A/G cg18135206 chr14:102964638 TECPR2 -0.99 -19.2 -0.72 6.63e-56 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg18402987 chr7:1209562 NA 0.44 5.93 0.31 7.75e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7681440 0.904 rs2301134 chr4:90758945 A/G cg20003494 chr4:90757398 SNCA -0.34 -5.71 -0.3 2.51e-8 Dementia with Lewy bodies; LUSC trans rs11039798 0.841 rs12221667 chr11:48548549 G/T cg15704280 chr7:45808275 SEPT13 0.75 6.44 0.33 4.2e-10 Axial length; LUSC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg11812906 chr14:75593930 NEK9 -0.67 -11.61 -0.54 2.11e-26 Height; LUSC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg21665744 chr7:39171113 POU6F2 0.47 7.46 0.38 7.58e-13 IgG glycosylation; LUSC cis rs73198271 0.515 rs113056462 chr8:8638568 T/C cg01851573 chr8:8652454 MFHAS1 0.56 6.24 0.32 1.32e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4148883 0.675 rs10000357 chr4:100099942 G/C cg12011299 chr4:100065546 ADH4 0.47 7.67 0.39 1.9e-13 Alcohol dependence; LUSC cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg01849466 chr14:104193079 ZFYVE21 0.57 9.01 0.44 1.64e-17 Schizophrenia; LUSC cis rs611744 0.870 rs613261 chr8:109165949 A/G cg18478394 chr8:109455254 TTC35 0.42 6.32 0.33 8.15e-10 Dupuytren's disease; LUSC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.77e-34 Aortic root size; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05653691 chr1:16175060 FLJ37453;SPEN 0.79 6.36 0.33 6.51e-10 Cognitive performance; LUSC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg06713675 chr4:122721982 EXOSC9 -0.72 -12.31 -0.56 5.85e-29 Type 2 diabetes; LUSC cis rs6484504 0.652 rs494464 chr11:31386150 C/T cg06552810 chr11:31128660 NA 0.39 6.77 0.35 5.87e-11 Red blood cell count; LUSC trans rs629535 0.862 rs2472141 chr8:70054216 T/C cg21567404 chr3:27674614 NA 0.98 15.62 0.65 1.15e-41 Dupuytren's disease; LUSC cis rs1044826 0.597 rs1017468 chr3:139145778 A/G cg15131784 chr3:139108705 COPB2 0.42 6.95 0.36 1.89e-11 Obesity-related traits; LUSC cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.46 0.46 5.88e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs61931739 0.500 rs11052994 chr12:34065843 C/T cg13010199 chr12:38710504 ALG10B 0.57 8.61 0.43 2.89e-16 Morning vs. evening chronotype; LUSC cis rs72781680 0.898 rs55846516 chr2:24158003 T/C cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs12950390 0.893 rs4794110 chr17:45847230 A/G cg03474202 chr17:45855739 NA -0.29 -6.71 -0.34 8.44e-11 IgG glycosylation; LUSC cis rs1950626 0.623 rs35947256 chr14:101460366 G/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.34 5.87 0.31 1.07e-8 Pelvic organ prolapse (moderate/severe); LUSC cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.39 0.33 5.53e-10 Rheumatoid arthritis; LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg08677398 chr8:58056175 NA -0.54 -7.32 -0.37 1.91e-12 Developmental language disorder (linguistic errors); LUSC cis rs477692 0.517 rs871026 chr10:131293145 A/G cg05714579 chr10:131428358 MGMT -0.44 -6.35 -0.33 7.02e-10 Response to temozolomide; LUSC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.4 0.49 3.98e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg13535736 chr9:111863775 C9orf5 -0.39 -6.2 -0.32 1.66e-9 Menarche (age at onset); LUSC trans rs4332037 0.805 rs10278591 chr7:1921362 A/G cg25206134 chr2:45395956 NA -0.5 -6.19 -0.32 1.76e-9 Bipolar disorder; LUSC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg13390004 chr1:15929781 NA 0.41 6.98 0.36 1.62e-11 Systolic blood pressure; LUSC cis rs34172651 0.917 rs200538 chr16:24735736 C/T cg06028605 chr16:24865363 SLC5A11 -0.47 -8.51 -0.42 5.9e-16 Intelligence (multi-trait analysis); LUSC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg05472934 chr7:22766657 IL6 0.51 7.93 0.4 3.31e-14 Lung cancer; LUSC cis rs12893668 0.673 rs2296482 chr14:104029819 T/G cg01849466 chr14:104193079 ZFYVE21 -0.45 -6.03 -0.31 4.45e-9 Reticulocyte count; LUSC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg21724239 chr8:58056113 NA 0.51 6.25 0.32 1.23e-9 Developmental language disorder (linguistic errors); LUSC cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg02475777 chr4:1388615 CRIPAK 0.41 6.35 0.33 7.22e-10 Longevity; LUSC cis rs6543140 0.964 rs11903551 chr2:103084181 C/G cg09003973 chr2:102972529 NA 0.53 6.75 0.35 6.5500000000000006e-11 Blood protein levels; LUSC cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg22709100 chr7:91322751 NA -0.39 -5.8 -0.3 1.52e-8 Breast cancer; LUSC cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg22709100 chr7:91322751 NA 0.39 5.8 0.3 1.5e-8 Breast cancer; LUSC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg18302933 chr2:88491318 NA -0.39 -7.56 -0.38 3.86e-13 Response to metformin (IC50); LUSC cis rs4631830 0.932 rs4581397 chr10:51532367 A/G cg16070123 chr10:51489643 NA -0.49 -7.67 -0.39 1.86e-13 Prostate-specific antigen levels; LUSC cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg18681998 chr4:17616180 MED28 0.83 14.72 0.63 3.85e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4285028 0.747 rs77790376 chr3:121492211 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.27 -0.45 2.45e-18 Multiple sclerosis; LUSC cis rs9287719 0.901 rs55861579 chr2:10763340 T/A cg00105475 chr2:10696890 NA 0.37 6.23 0.32 1.43e-9 Prostate cancer; LUSC cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg08873628 chr1:175162347 KIAA0040 0.39 5.68 0.3 2.99e-8 Diastolic blood pressure; LUSC cis rs4604732 0.603 rs10802512 chr1:247633730 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.34 5.65 0.3 3.49e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg06713675 chr4:122721982 EXOSC9 -0.69 -12.08 -0.55 3.95e-28 Type 2 diabetes; LUSC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.8 10.01 0.48 8.37e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11828289 0.660 rs74388652 chr11:23188048 A/G cg20040320 chr11:23191996 NA -0.58 -6.1 -0.32 2.95e-9 Cancer; LUSC cis rs8060686 0.545 rs8056649 chr16:68260083 A/G cg27539214 chr16:67997921 SLC12A4 0.44 5.8 0.3 1.56e-8 HDL cholesterol;Metabolic syndrome; LUSC trans rs9329221 0.662 rs12541491 chr8:10250048 C/T cg08975724 chr8:8085496 FLJ10661 0.46 6.12 0.32 2.68e-9 Neuroticism; LUSC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg05861140 chr6:150128134 PCMT1 -0.38 -6.04 -0.31 4.07e-9 Lung cancer; LUSC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg23791538 chr6:167370224 RNASET2 -0.43 -6.95 -0.36 1.93e-11 Crohn's disease; LUSC cis rs231513 1.000 rs231513 chr17:41965200 C/G cg26893861 chr17:41843967 DUSP3 -0.55 -6.29 -0.33 9.82e-10 Cognitive function; LUSC cis rs7940866 1.000 rs7940866 chr11:130817579 A/T cg12179176 chr11:130786555 SNX19 -0.62 -9.15 -0.45 5.82e-18 Schizophrenia; LUSC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.08 0.4 1.19e-14 Parkinson's disease; LUSC cis rs2835872 0.726 rs12482570 chr21:39077777 A/G cg20424643 chr21:39039972 KCNJ6 0.41 6.27 0.32 1.14e-9 Electroencephalographic traits in alcoholism; LUSC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.58 7.86 0.4 5.4e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4478037 1.000 rs58995409 chr3:33161404 T/C cg19404215 chr3:33155277 CRTAP 0.96 9.76 0.47 5.72e-20 Major depressive disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25528940 chr16:57127044 CPNE2 0.49 6.59 0.34 1.67e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg25258033 chr6:167368657 RNASET2 -0.49 -8.1 -0.41 1.04e-14 Crohn's disease; LUSC cis rs11997175 0.624 rs4733175 chr8:33679744 T/A ch.8.33884649F chr8:33765107 NA 0.47 7.08 0.36 8.69e-12 Body mass index; LUSC cis rs4654899 0.931 rs3767241 chr1:21166144 C/T cg01072550 chr1:21505969 NA 0.47 7.15 0.36 5.5e-12 Superior frontal gyrus grey matter volume; LUSC cis rs9311676 0.632 rs1126735 chr3:58413408 A/G cg13750441 chr3:58318267 PXK 0.36 6.87 0.35 3.18e-11 Systemic lupus erythematosus; LUSC cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.29 0.37 2.31e-12 Motion sickness; LUSC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg15534755 chr11:117069859 TAGLN 0.34 6.09 0.32 3.16e-9 Blood protein levels; LUSC trans rs2275620 0.513 rs2860976 chr10:96789846 C/A cg08498836 chr3:149292366 WWTR1 0.36 6.16 0.32 2.12e-9 Gout; LUSC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg04267008 chr7:1944627 MAD1L1 -0.5 -7.56 -0.38 3.9e-13 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16857015 chr3:49142290 QARS 0.44 5.97 0.31 6.13e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs11585357 0.895 rs72633823 chr1:17630779 G/A cg08277548 chr1:17600880 PADI3 -0.61 -6.38 -0.33 5.92e-10 Hair shape; LUSC cis rs34734847 0.842 rs556001 chr12:121152967 A/G cg21892295 chr12:121157589 UNC119B -0.49 -8.96 -0.44 2.27e-17 Mean corpuscular volume; LUSC cis rs28647808 0.786 rs4962136 chr9:136256794 A/G cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg11584989 chr19:19387371 SF4 -0.61 -7.14 -0.36 5.86e-12 Bipolar disorder; LUSC cis rs9527 0.590 rs7088200 chr10:104793235 G/A cg05855489 chr10:104503620 C10orf26 0.53 8.12 0.41 9.19e-15 Arsenic metabolism; LUSC cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg00857998 chr1:205179979 DSTYK 0.57 8.52 0.42 5.73e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg18230493 chr5:56204884 C5orf35 -0.61 -9.65 -0.47 1.32e-19 Coronary artery disease; LUSC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg24739457 chr1:205821442 NA -0.35 -6.0 -0.31 5.27e-9 Menarche (age at onset); LUSC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg27494647 chr7:150038898 RARRES2 0.5 7.35 0.37 1.56e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs12295403 0.964 rs34364314 chr11:18691674 G/A cg09887367 chr11:18690185 NA -0.37 -7.74 -0.39 1.18e-13 Ovarian reserve; LUSC cis rs6723226 0.699 rs376914 chr2:32508393 G/C cg02381751 chr2:32503542 YIPF4 0.6 8.91 0.44 3.41e-17 Intelligence (multi-trait analysis); LUSC cis rs7918232 0.891 rs10443987 chr10:27375377 A/T cg14240646 chr10:27532245 ACBD5 -0.69 -8.04 -0.4 1.55e-14 Breast cancer; LUSC cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg04398451 chr17:18023971 MYO15A -0.53 -8.55 -0.42 4.4e-16 Total body bone mineral density; LUSC cis rs8258 0.501 rs474490 chr11:117287794 T/G cg15227623 chr11:117232454 CEP164 0.52 6.81 0.35 4.59e-11 Pulse pressure; LUSC cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -10.91 -0.51 6.51e-24 Chronic sinus infection; LUSC cis rs738322 1.000 rs738320 chr22:38568715 G/T cg25457927 chr22:38595422 NA -0.41 -8.46 -0.42 8.33e-16 Cutaneous nevi; LUSC cis rs1178968 0.818 rs4717084 chr7:72764541 C/T cg25889504 chr7:72793014 NA 0.59 7.75 0.39 1.11e-13 Triglyceride levels; LUSC cis rs5769765 0.955 rs4075330 chr22:50303249 G/A cg26441486 chr22:50317300 CRELD2 0.5 7.85 0.39 5.61e-14 Schizophrenia; LUSC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg11645453 chr3:52864694 ITIH4 0.35 8.0 0.4 2.1e-14 Bipolar disorder; LUSC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg15556689 chr8:8085844 FLJ10661 -0.68 -11.49 -0.53 5.68e-26 Mood instability; LUSC cis rs9467773 0.869 rs742090 chr6:26415637 A/C cg05738196 chr6:26577821 NA -0.69 -11.33 -0.53 2.16e-25 Intelligence (multi-trait analysis); LUSC cis rs17767294 0.612 rs9461424 chr6:27919401 G/A cg08851530 chr6:28072375 NA 0.84 6.48 0.33 3.21e-10 Parkinson's disease; LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.96 0.51 4.51e-24 Menopause (age at onset); LUSC trans rs2392780 0.536 rs437980 chr8:128335246 A/C cg10195415 chr17:73887371 TRIM65 0.41 6.49 0.33 3.12e-10 Breast cancer (early onset); LUSC cis rs3824867 0.770 rs11820680 chr11:47452744 C/T cg20307385 chr11:47447363 PSMC3 -0.65 -9.65 -0.47 1.35e-19 Mean corpuscular hemoglobin; LUSC cis rs2637266 0.626 rs1660914 chr10:78525319 T/A cg18941641 chr10:78392320 NA 0.38 7.02 0.36 1.23e-11 Pulmonary function; LUSC cis rs1790761 0.667 rs658768 chr11:67337808 G/A cg23188684 chr11:67383651 NA 0.35 6.19 0.32 1.76e-9 Mean corpuscular volume; LUSC cis rs1595825 0.891 rs73058864 chr2:198889587 C/T cg00982548 chr2:198649783 BOLL -0.54 -6.93 -0.35 2.2e-11 Ulcerative colitis; LUSC cis rs6545883 0.718 rs3771260 chr2:61762384 G/T cg15711740 chr2:61764176 XPO1 -0.49 -7.77 -0.39 9.91e-14 Tuberculosis; LUSC trans rs1814175 0.817 rs1621090 chr11:49895868 C/A cg03929089 chr4:120376271 NA -1.03 -20.21 -0.74 7.12e-60 Height; LUSC cis rs3820928 0.839 rs12151848 chr2:227859326 G/A cg11843606 chr2:227700838 RHBDD1 -0.51 -7.31 -0.37 1.99e-12 Pulmonary function; LUSC cis rs6674970 0.518 rs6587552 chr1:151018861 C/T cg03258749 chr1:151040405 MLLT11 0.5 7.44 0.38 8.36e-13 Childhood ear infection; LUSC cis rs10979 0.562 rs9399446 chr6:143874639 G/C cg25407410 chr6:143891975 LOC285740 -0.53 -7.49 -0.38 6.01e-13 Hypospadias; LUSC cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.56 -0.6 1.12e-33 Chronic sinus infection; LUSC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg05425664 chr17:57184151 TRIM37 0.53 7.79 0.39 8.64e-14 Intelligence (multi-trait analysis); LUSC cis rs4242434 0.672 rs900267 chr8:22485258 T/C cg03733263 chr8:22462867 KIAA1967 0.77 12.46 0.56 1.65e-29 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs3820928 0.904 rs6735069 chr2:227893660 A/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.51 -0.38 5.58e-13 Pulmonary function; LUSC cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg15839431 chr19:19639596 YJEFN3 -0.65 -7.21 -0.37 3.87e-12 Bipolar disorder; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11668638 chr6:42952412 PPP2R5D 0.47 6.79 0.35 5.12e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9595066 0.712 rs4391951 chr13:44755071 C/T cg04068111 chr13:44716778 NA 0.47 6.08 0.32 3.26e-9 Schizophrenia; LUSC cis rs611744 0.905 rs610891 chr8:109161003 C/T cg18478394 chr8:109455254 TTC35 -0.39 -5.82 -0.3 1.41e-8 Dupuytren's disease; LUSC cis rs11711311 1.000 rs12637066 chr3:113527574 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.84 -0.3 1.23e-8 IgG glycosylation; LUSC cis rs868036 0.681 rs4776977 chr15:68108219 C/T cg05925327 chr15:68127851 NA -0.4 -6.4 -0.33 5.35e-10 Restless legs syndrome; LUSC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg13175981 chr1:150552382 MCL1 0.47 6.77 0.35 5.66e-11 Tonsillectomy; LUSC cis rs34375054 0.525 rs7136220 chr12:125602684 T/C cg00522288 chr12:125625016 AACS -0.31 -5.89 -0.31 9.19e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg19418458 chr7:158789849 NA -0.53 -8.65 -0.43 2.19e-16 Facial morphology (factor 20); LUSC cis rs1483890 0.642 rs1843050 chr3:69403918 C/T cg22125112 chr3:69402811 FRMD4B -0.41 -6.03 -0.31 4.35e-9 Resting heart rate; LUSC cis rs34779708 0.931 rs12248333 chr10:35362977 A/G cg04310649 chr10:35416472 CREM -0.41 -6.44 -0.33 4.26e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs1325195 0.920 rs1856968 chr1:179100045 C/T cg11624085 chr17:8464688 MYH10 0.44 7.3 0.37 2.12e-12 IgE grass sensitization; LUSC cis rs12367572 0.965 rs1506678 chr12:45249492 A/G cg04608330 chr12:45269318 NELL2 -0.57 -9.32 -0.45 1.57e-18 Gut microbiome composition (summer); LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.69 0.54 1.04e-26 Prudent dietary pattern; LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg13395646 chr4:1353034 KIAA1530 -0.62 -9.81 -0.47 3.86e-20 Obesity-related traits; LUSC trans rs225245 0.755 rs6505493 chr17:34028901 A/G cg19694781 chr19:47549865 TMEM160 -0.4 -6.31 -0.33 8.84e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs7605827 0.866 rs6752546 chr2:15630729 T/C cg19274914 chr2:15703543 NA 0.46 8.87 0.44 4.51e-17 Educational attainment (years of education); LUSC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg11247378 chr22:39784982 NA -0.64 -11.55 -0.53 3.31e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg26338869 chr17:61819248 STRADA 0.42 6.17 0.32 1.99e-9 Prudent dietary pattern; LUSC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg12386194 chr3:101231763 SENP7 0.64 8.95 0.44 2.44e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg18404041 chr3:52824283 ITIH1 -0.58 -11.03 -0.52 2.51e-24 Bipolar disorder; LUSC cis rs2067615 0.524 rs10778499 chr12:107068387 C/T cg15890332 chr12:107067104 RFX4 0.35 6.19 0.32 1.72e-9 Heart rate; LUSC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg11645453 chr3:52864694 ITIH4 0.35 8.2 0.41 5.27e-15 Bipolar disorder; LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.08 0.55 4.01e-28 Prudent dietary pattern; LUSC cis rs870825 0.616 rs28463742 chr4:185611005 G/A cg04058563 chr4:185651563 MLF1IP 0.85 12.92 0.58 3.12e-31 Blood protein levels; LUSC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.47 -6.97 -0.36 1.71e-11 Alzheimer's disease (late onset); LUSC cis rs2439831 0.850 rs3736180 chr15:44106624 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.68 0.34 9.91e-11 Lung cancer in ever smokers; LUSC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg08847533 chr14:75593920 NEK9 -0.81 -14.48 -0.62 3.16e-37 Height; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg06873352 chr17:61820015 STRADA 0.7 12.66 0.57 2.96e-30 Prudent dietary pattern; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.84e-30 Prudent dietary pattern; LUSC cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg22676075 chr6:135203613 NA 0.59 9.49 0.46 4.37e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.44 6.58 0.34 1.82e-10 Rheumatoid arthritis; LUSC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.41 5.72 0.3 2.38e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.898 rs111460347 chr2:24018833 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs9296092 0.517 rs113111213 chr6:33520790 A/G cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg00074818 chr8:8560427 CLDN23 0.58 9.9 0.48 1.91e-20 Obesity-related traits; LUSC cis rs7937682 0.924 rs10891288 chr11:111552053 G/T cg22437258 chr11:111473054 SIK2 -0.5 -6.82 -0.35 4.24e-11 Primary sclerosing cholangitis; LUSC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.4 0.38 1.13e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg23158103 chr7:148848205 ZNF398 -0.48 -7.87 -0.4 5.09e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs360798 0.512 rs11893131 chr2:63079528 C/A cg17519650 chr2:63277830 OTX1 0.48 6.75 0.35 6.56e-11 Coronary artery disease; LUSC cis rs3806843 1.000 rs7710794 chr5:140209467 T/G cg19875535 chr5:140030758 IK 0.46 7.32 0.37 1.91e-12 Depressive symptoms (multi-trait analysis); LUSC trans rs9650657 0.645 rs9969657 chr8:10515278 A/G cg06636001 chr8:8085503 FLJ10661 0.47 7.13 0.36 6.41e-12 Neuroticism; LUSC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg18099408 chr3:52552593 STAB1 -0.41 -7.03 -0.36 1.2e-11 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg27170947 chr2:26402098 FAM59B -0.66 -9.6 -0.46 2e-19 Gut microbiome composition (summer); LUSC cis rs2836633 0.929 rs2836602 chr21:40039169 A/T cg05519781 chr21:40033154 ERG -0.73 -12.23 -0.56 1.11e-28 Coronary artery disease; LUSC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg24060327 chr5:131705240 SLC22A5 -0.38 -6.27 -0.32 1.09e-9 Lung function (FEV1/FVC); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19213194 chr7:101632618 CUX1 0.41 6.31 0.33 9.07e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs590121 0.876 rs649257 chr11:75279846 C/T cg26104986 chr11:75275303 SERPINH1 -0.3 -6.17 -0.32 2e-9 Coronary artery disease; LUSC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg08888203 chr3:10149979 C3orf24 0.62 8.51 0.42 5.77e-16 Alzheimer's disease; LUSC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg20307385 chr11:47447363 PSMC3 -0.47 -6.09 -0.32 3.14e-9 Subjective well-being; LUSC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg13206674 chr6:150067644 NUP43 0.6 9.65 0.47 1.37e-19 Lung cancer; LUSC cis rs68170813 0.562 rs11770061 chr7:107071310 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.26 -0.45 2.55e-18 Coronary artery disease; LUSC cis rs7098414 0.511 rs7071752 chr10:82159539 C/A cg01528321 chr10:82214614 TSPAN14 0.63 9.4 0.46 8.76e-19 Post bronchodilator FEV1; LUSC cis rs68170813 0.559 rs77671232 chr7:106939202 A/G cg02696742 chr7:106810147 HBP1 -0.62 -9.55 -0.46 2.87e-19 Coronary artery disease; LUSC cis rs10744422 0.925 rs2880678 chr12:123317099 C/T cg25930673 chr12:123319894 HIP1R -0.64 -6.29 -0.33 9.88e-10 Schizophrenia; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.16 0.32 2.08e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1577917 1.000 rs12212733 chr6:86726013 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.68e-17 Response to antipsychotic treatment; LUSC trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.520 rs12467504 chr2:99543208 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.51 -6.32 -0.33 8.52e-10 Chronic sinus infection; LUSC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg22535103 chr8:58192502 C8orf71 0.58 7.13 0.36 6.09e-12 Developmental language disorder (linguistic errors); LUSC cis rs7940866 0.774 rs12420126 chr11:130834811 C/T cg12179176 chr11:130786555 SNX19 0.63 9.44 0.46 6.54e-19 Schizophrenia; LUSC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg09455208 chr3:40491958 NA -0.56 -10.44 -0.5 2.92e-22 Renal cell carcinoma; LUSC cis rs7804356 1.000 rs3801837 chr7:26851361 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs2408955 0.522 rs6580650 chr12:48418556 G/T cg24011408 chr12:48396354 COL2A1 -0.43 -6.15 -0.32 2.17e-9 Glycated hemoglobin levels; LUSC cis rs3931020 0.508 rs2345436 chr1:75198740 A/C cg10128416 chr1:75198403 TYW3;CRYZ 0.58 8.33 0.41 2.08e-15 Resistin levels; LUSC cis rs36093844 0.800 rs11826218 chr11:85568522 T/G cg25872744 chr11:85566296 CCDC83 -0.45 -5.85 -0.3 1.16e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs861020 0.630 rs656566 chr1:210006603 C/T cg05527609 chr1:210001259 C1orf107 0.67 9.63 0.47 1.5700000000000001e-19 Orofacial clefts; LUSC cis rs71403859 0.803 rs10500562 chr16:71627731 A/C cg08717414 chr16:71523259 ZNF19 -0.75 -8.3 -0.41 2.56e-15 Post bronchodilator FEV1; LUSC cis rs427941 0.703 rs1637257 chr7:101740606 T/G cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg12705353 chr12:122356852 WDR66 0.39 5.65 0.3 3.36e-8 Mean corpuscular volume; LUSC cis rs4242434 0.819 rs7826059 chr8:22512068 T/C cg03733263 chr8:22462867 KIAA1967 -0.81 -13.05 -0.58 9.62e-32 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs61990749 0.597 rs2112136 chr14:78248952 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.63 6.65 0.34 1.23e-10 Fibroblast growth factor basic levels; LUSC cis rs4474465 0.850 rs4945294 chr11:78256864 G/A cg27205649 chr11:78285834 NARS2 0.52 6.2 0.32 1.7e-9 Alzheimer's disease (survival time); LUSC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg20503657 chr10:835505 NA 1.21 16.65 0.67 9.2e-46 Eosinophil percentage of granulocytes; LUSC cis rs10028773 0.515 rs9994651 chr4:120587803 C/T cg24375607 chr4:120327624 NA 0.64 9.47 0.46 5.14e-19 Educational attainment; LUSC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg05347473 chr6:146136440 FBXO30 -0.58 -10.0 -0.48 9.4e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs12541335 0.603 rs9792127 chr8:22180334 G/A cg02788857 chr8:22132959 PIWIL2 0.39 7.39 0.37 1.18e-12 Hypertriglyceridemia; LUSC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg06008330 chr7:65541103 ASL 0.37 5.66 0.3 3.26e-8 Aortic root size; LUSC cis rs4555082 0.874 rs78923231 chr14:105754033 C/T cg10792982 chr14:105748885 BRF1 0.51 8.77 0.43 9.54e-17 Mean platelet volume;Platelet distribution width; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg20295408 chr7:1910781 MAD1L1 -0.45 -6.14 -0.32 2.4e-9 Bipolar disorder and schizophrenia; LUSC cis rs35000415 0.745 rs117944677 chr7:128698185 A/T cg19972273 chr7:128594194 NA 0.63 5.72 0.3 2.34e-8 Systemic lupus erythematosus; LUSC cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.18 0.41 6.18e-15 Colorectal cancer; LUSC cis rs62400317 0.859 rs56283067 chr6:45100330 T/C cg20913747 chr6:44695427 NA -0.47 -7.4 -0.38 1.15e-12 Total body bone mineral density; LUSC cis rs56399783 0.614 rs116929101 chr7:2760325 G/A cg14895029 chr7:2775587 GNA12 0.52 5.65 0.3 3.38e-8 Childhood ear infection; LUSC cis rs13191362 0.573 rs1877769 chr6:163252315 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.54 7.79 0.39 8.47e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs6754311 0.628 rs309811 chr2:136625602 A/G cg25344623 chr2:136566232 LCT 0.37 5.7 0.3 2.64e-8 Mosquito bite size; LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg02018176 chr4:1364513 KIAA1530 0.51 8.74 0.43 1.14e-16 Obesity-related traits; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg25795197 chr3:88107754 CGGBP1 0.47 6.7 0.34 8.71e-11 Triglycerides; LUSC cis rs847577 0.609 rs6965016 chr7:97807882 C/A cg24562669 chr7:97807699 LMTK2 0.48 8.56 0.42 4.17e-16 Breast cancer; LUSC cis rs4911259 0.552 rs62208880 chr20:31463284 T/C cg13636640 chr20:31349939 DNMT3B -0.81 -15.51 -0.65 3.12e-41 Inflammatory bowel disease; LUSC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.66 -0.54 1.34e-26 Mean corpuscular volume; LUSC cis rs9815354 0.812 rs73071307 chr3:41798699 T/C cg03022575 chr3:42003672 ULK4 0.85 8.73 0.43 1.23e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs3125734 0.582 rs7904465 chr10:64002393 G/A cg09941381 chr10:64027924 RTKN2 -0.39 -7.34 -0.37 1.68e-12 Rheumatoid arthritis; LUSC cis rs751728 1.000 rs6920075 chr6:33731797 C/T cg25922239 chr6:33757077 LEMD2 0.54 8.13 0.41 8.25e-15 Crohn's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09290614 chr3:38691371 SCN5A 0.58 8.3 0.41 2.69e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.95 0.44 2.52e-17 Prudent dietary pattern; LUSC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg00825309 chr19:58991885 ZNF446 -0.49 -7.1 -0.36 7.49e-12 Uric acid clearance; LUSC cis rs4727027 0.631 rs62507511 chr7:148796080 C/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.54 7.39 0.37 1.19e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9902453 1.000 rs12600855 chr17:28279591 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.12 0.45 7.13e-18 Coffee consumption (cups per day); LUSC cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -10.92 -0.51 5.97e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9322817 0.715 rs6918700 chr6:105244526 A/T cg02098413 chr6:105308735 HACE1 -0.28 -5.77 -0.3 1.85e-8 Thyroid stimulating hormone; LUSC cis rs7241530 0.662 rs7237276 chr18:75907694 C/T cg14642773 chr18:75888474 NA 0.38 5.66 0.3 3.2e-8 Educational attainment (years of education); LUSC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.11 0.32 2.79e-9 Schizophrenia; LUSC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg00121533 chr1:75199117 CRYZ;TYW3 -0.51 -7.32 -0.37 1.92e-12 Resistin levels; LUSC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg15445000 chr17:37608096 MED1 -0.38 -6.57 -0.34 1.96e-10 Glomerular filtration rate (creatinine); LUSC cis rs654950 0.875 rs633297 chr1:41985453 A/C cg06885757 chr1:42089581 HIVEP3 0.35 6.95 0.36 1.97e-11 Airway imaging phenotypes; LUSC cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs8017423 1.000 rs8015379 chr14:90679432 C/T cg04374321 chr14:90722782 PSMC1 0.7 11.18 0.52 7.29e-25 Mortality in heart failure; LUSC cis rs7572644 0.699 rs10171517 chr2:28090059 T/C cg27432699 chr2:27873401 GPN1 -0.52 -6.72 -0.35 7.73e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg03188948 chr7:1209495 NA 0.61 6.38 0.33 5.97e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg19468946 chr17:37922297 IKZF3 -0.43 -6.78 -0.35 5.33e-11 Self-reported allergy; LUSC cis rs601339 1.000 rs645491 chr12:123181661 T/C cg11919336 chr12:123188078 GPR109A 0.44 6.58 0.34 1.87e-10 Adiponectin levels; LUSC cis rs12900413 0.959 rs12902793 chr15:90304402 G/A cg24249390 chr15:90295951 MESP1 -0.46 -6.67 -0.34 1.04e-10 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg19875535 chr5:140030758 IK 0.47 7.64 0.39 2.37e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs10782582 0.609 rs6656501 chr1:76266126 A/C cg10523679 chr1:76189770 ACADM -0.48 -6.96 -0.36 1.85e-11 Daytime sleep phenotypes; LUSC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg14668632 chr7:2872130 GNA12 -0.46 -7.07 -0.36 9.1e-12 Height; LUSC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg18876405 chr7:65276391 NA 0.55 8.79 0.43 8.1e-17 Aortic root size; LUSC cis rs936229 0.813 rs4886619 chr15:75106138 C/T cg10253484 chr15:75165896 SCAMP2 -0.53 -7.16 -0.36 5.12e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs8180040 0.764 rs13061071 chr3:47138708 G/A cg02527881 chr3:46936655 PTH1R -0.41 -7.27 -0.37 2.61e-12 Colorectal cancer; LUSC cis rs7809950 0.731 rs2712196 chr7:107128797 G/T cg23024343 chr7:107201750 COG5 -0.68 -10.18 -0.49 2.17e-21 Coronary artery disease; LUSC cis rs12530845 0.623 rs73721664 chr7:135343575 A/C cg23117316 chr7:135346802 PL-5283 -0.66 -9.89 -0.48 2.17e-20 Red blood cell traits; LUSC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg18876405 chr7:65276391 NA -0.58 -9.35 -0.46 1.32e-18 Aortic root size; LUSC cis rs2841277 0.676 rs4264326 chr14:105411700 A/G cg14403583 chr14:105418241 AHNAK2 -0.58 -9.75 -0.47 6.06e-20 Rheumatoid arthritis; LUSC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg15017067 chr4:17643749 FAM184B 0.35 6.0 0.31 5.16e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg18876405 chr7:65276391 NA 0.54 8.47 0.42 8.18e-16 Aortic root size; LUSC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg12310025 chr6:25882481 NA -0.6 -10.15 -0.49 2.8e-21 Intelligence (multi-trait analysis); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03043709 chr7:2046920 MAD1L1 -0.73 -6.45 -0.33 3.92e-10 Cognitive performance; LUSC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg11235426 chr6:292522 DUSP22 -0.47 -6.97 -0.36 1.67e-11 Menopause (age at onset); LUSC cis rs62408225 0.890 rs2134814 chr6:90987512 C/G cg06866423 chr6:90926672 BACH2 0.41 5.88 0.31 9.97e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs62458065 0.513 rs10245103 chr7:32534829 T/G cg20159608 chr7:32802032 NA -0.7 -9.04 -0.44 1.3e-17 Metabolite levels (HVA/MHPG ratio); LUSC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg27494647 chr7:150038898 RARRES2 0.44 6.74 0.35 6.99e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs921968 0.541 rs7603816 chr2:219396255 C/T cg02176678 chr2:219576539 TTLL4 -0.74 -14.43 -0.62 5.11e-37 Mean corpuscular hemoglobin concentration; LUSC cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg11244672 chr19:19639970 YJEFN3 0.57 7.25 0.37 2.99e-12 Bipolar disorder; LUSC cis rs1982963 0.950 rs61973203 chr14:52510567 A/G cg10843707 chr14:52510701 NID2 0.42 7.27 0.37 2.59e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs62432291 0.681 rs445957 chr6:159662064 C/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.11 -0.32 2.73e-9 Joint mobility (Beighton score); LUSC cis rs2404602 0.622 rs11632670 chr15:76974055 A/G cg23625390 chr15:77176239 SCAPER -0.66 -10.4 -0.49 3.84e-22 Blood metabolite levels; LUSC cis rs6733011 0.600 rs1356424 chr2:99425838 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.41 -5.79 -0.3 1.6e-8 Bipolar disorder; LUSC cis rs6942756 1.000 rs6971917 chr7:128976919 G/A cg02491457 chr7:128862824 NA -0.48 -6.38 -0.33 5.8e-10 White matter hyperintensity burden; LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg25072359 chr17:41440525 NA 0.65 9.22 0.45 3.32e-18 Menopause (age at onset); LUSC cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14083397 chr20:388473 RBCK1 -0.48 -6.17 -0.32 2e-9 Hepatitis; LUSC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg21951975 chr1:209979733 IRF6 0.54 6.78 0.35 5.33e-11 Cleft lip with or without cleft palate; LUSC cis rs240764 0.658 rs11155666 chr6:101234841 G/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.09 -0.32 3.1e-9 Neuroticism; LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg22166914 chr1:53195759 ZYG11B 0.48 7.69 0.39 1.66e-13 Monocyte count; LUSC cis rs1348850 0.914 rs6761593 chr2:178451600 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.5 -6.44 -0.33 4.09e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg04369109 chr6:150039330 LATS1 -0.55 -8.11 -0.41 9.41e-15 Lung cancer; LUSC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11890956 chr21:40555474 PSMG1 0.96 17.39 0.69 1.06e-48 Cognitive function; LUSC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg20135002 chr11:47629003 NA -0.5 -7.76 -0.39 1.05e-13 Subjective well-being; LUSC cis rs7178572 0.568 rs12900433 chr15:77495028 T/C cg22256960 chr15:77711686 NA -0.5 -8.05 -0.4 1.5e-14 Type 2 diabetes; LUSC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg07701084 chr6:150067640 NUP43 0.57 8.9 0.44 3.61e-17 Lung cancer; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg11028586 chr17:33307483 LIG3 0.4 6.35 0.33 7.1e-10 Risky sexual behaviors in alcohol dependence; LUSC trans rs9467711 0.659 rs35433030 chr6:26529890 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.64 -0.34 1.3e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.82 12.4 0.56 2.57e-29 Cognitive test performance; LUSC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg14668632 chr7:2872130 GNA12 -0.43 -5.97 -0.31 5.93e-9 Height; LUSC cis rs2742234 0.955 rs1800861 chr10:43613843 G/T cg02780029 chr10:43622663 RET -0.33 -6.12 -0.32 2.61e-9 Hirschsprung disease; LUSC cis rs6580649 0.883 rs879242 chr12:48503301 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.1 -0.32 2.9e-9 Lung cancer; LUSC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs11122272 0.735 rs2790877 chr1:231535427 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.0 -0.48 9.09e-21 Hemoglobin concentration; LUSC cis rs4400599 0.618 rs1194582 chr1:154215973 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.9 -0.31 8.97e-9 Platelet distribution width; LUSC cis rs4237845 0.537 rs59401446 chr12:58259564 G/A cg00677455 chr12:58241039 CTDSP2 0.72 11.27 0.53 3.35e-25 Intelligence (multi-trait analysis); LUSC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg21028142 chr17:79581711 NPLOC4 0.34 8.17 0.41 6.66e-15 Eye color traits; LUSC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg11764359 chr7:65958608 NA -0.7 -10.85 -0.51 1.03e-23 Aortic root size; LUSC cis rs7940866 0.738 rs10791114 chr11:130889850 G/A cg12179176 chr11:130786555 SNX19 0.63 9.78 0.47 4.87e-20 Schizophrenia; LUSC trans rs6598955 0.671 rs12141563 chr1:26589636 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.89 -0.44 3.86e-17 Obesity-related traits; LUSC cis rs11122272 0.525 rs61835222 chr1:231537917 C/A cg06096015 chr1:231504339 EGLN1 0.54 9.4 0.46 8.91e-19 Hemoglobin concentration; LUSC cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.8 8.04 0.4 1.62e-14 Lung cancer in ever smokers; LUSC cis rs4478037 1.000 rs59622575 chr3:33162249 A/C cg19404215 chr3:33155277 CRTAP 0.96 10.11 0.48 4.01e-21 Major depressive disorder; LUSC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg02569458 chr12:86230093 RASSF9 0.58 9.78 0.47 4.91e-20 Major depressive disorder; LUSC cis rs7202877 0.706 rs11149812 chr16:75323645 T/C cg04384234 chr16:75411784 CFDP1 -0.62 -8.63 -0.43 2.53e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg05347473 chr6:146136440 FBXO30 -0.56 -9.57 -0.46 2.44e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg04369109 chr6:150039330 LATS1 -0.57 -8.41 -0.42 1.2e-15 Lung cancer; LUSC cis rs2806561 0.765 rs1738468 chr1:23510850 T/G cg12483005 chr1:23474871 LUZP1 0.42 6.62 0.34 1.47e-10 Height; LUSC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg08048268 chr3:133502702 NA 0.38 7.61 0.38 2.85e-13 Iron status biomarkers; LUSC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.29 0.37 2.32e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4073221 0.520 rs13072195 chr3:18199498 C/T cg07694806 chr3:18168406 NA -0.67 -6.48 -0.33 3.2e-10 Parkinson's disease; LUSC trans rs9847048 0.715 rs78854293 chr3:116367255 C/T cg11621464 chr19:41120268 LTBP4 -0.62 -6.02 -0.31 4.5e-9 Gut microbiome composition (summer); LUSC cis rs6062509 0.965 rs6062506 chr20:62352389 T/G cg01176363 chr20:62369445 LIME1 -0.46 -6.98 -0.36 1.63e-11 Prostate cancer; LUSC cis rs300703 0.935 rs417829 chr2:206851 A/G cg21211680 chr2:198530 NA 0.68 7.04 0.36 1.11e-11 Blood protein levels; LUSC cis rs8060686 0.641 rs28548264 chr16:68211321 A/G cg05110241 chr16:68378359 PRMT7 -0.53 -6.16 -0.32 2.11e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs62400317 0.859 rs10948205 chr6:45124585 T/C cg18551225 chr6:44695536 NA -0.42 -6.82 -0.35 4.23e-11 Total body bone mineral density; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06987936 chr6:74406097 CD109 -0.49 -6.17 -0.32 1.97e-9 Bipolar disorder and schizophrenia; LUSC cis rs7177699 0.534 rs4387568 chr15:79109514 C/G cg00540400 chr15:79124168 NA -0.47 -8.24 -0.41 3.92e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg26380479 chr7:97908229 NA -0.27 -5.89 -0.31 9.67e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg23711669 chr6:146136114 FBXO30 0.92 18.0 0.7 3.97e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs7769051 0.711 rs9493435 chr6:133088205 A/G cg22852734 chr6:133119734 C6orf192 1.08 12.84 0.57 6.03e-31 Type 2 diabetes nephropathy; LUSC cis rs713587 0.525 rs11675457 chr2:25079770 C/T cg15423357 chr2:25149977 NA 0.36 7.01 0.36 1.34e-11 Body mass index in non-asthmatics; LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.93 0.66 6.49e-43 Platelet count; LUSC cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg08085267 chr17:45401833 C17orf57 -0.46 -6.63 -0.34 1.35e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1348850 0.632 rs1405718 chr2:178499809 C/T cg22681709 chr2:178499509 PDE11A -0.57 -11.54 -0.53 3.62e-26 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.35 7.33 0.37 1.75e-12 Hemoglobin concentration; LUSC cis rs738322 0.934 rs133016 chr22:38572582 C/T cg17652424 chr22:38574118 PLA2G6 -0.3 -6.43 -0.33 4.3e-10 Cutaneous nevi; LUSC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.85 -0.31 1.15e-8 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg11764359 chr7:65958608 NA 0.7 10.83 0.51 1.22e-23 Aortic root size; LUSC cis rs7851660 0.772 rs6478471 chr9:100664382 A/G cg13688889 chr9:100608707 NA -0.54 -8.39 -0.42 1.4e-15 Strep throat; LUSC cis rs10761482 0.861 rs7084803 chr10:62107101 T/C cg18175470 chr10:62150864 ANK3 -0.51 -7.24 -0.37 3.06e-12 Schizophrenia; LUSC cis rs2439831 1.000 rs1814538 chr15:43759774 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.85 -8.82 -0.43 6.69e-17 Lung cancer in ever smokers; LUSC trans rs11992162 0.573 rs13275808 chr8:11782815 T/C cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.46e-10 Monocyte count; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg14514174 chr9:99181512 ZNF367 -0.39 -6.53 -0.34 2.43e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg24675658 chr1:53192096 ZYG11B 0.73 12.45 0.56 1.77e-29 Monocyte count; LUSC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg17173187 chr15:85201210 NMB 0.38 6.93 0.35 2.21e-11 Schizophrenia; LUSC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.07 -0.32 3.41e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2758596 1.000 rs2758617 chr1:156160693 A/G cg24450063 chr1:156163899 SLC25A44 1.04 8.47 0.42 7.73e-16 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs2290416 0.892 rs77370907 chr8:144664975 G/C cg08017634 chr8:144659831 NAPRT1 0.7 6.15 0.32 2.16e-9 Attention deficit hyperactivity disorder; LUSC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg04369109 chr6:150039330 LATS1 -0.52 -7.5 -0.38 5.95e-13 Lung cancer; LUSC trans rs13011075 0.878 rs6714719 chr2:68593773 G/C cg14221825 chr19:46271408 SIX5 0.43 6.03 0.31 4.38e-9 Mean corpuscular volume; LUSC trans rs61931739 0.500 rs7295779 chr12:34460652 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.2 0.45 3.89e-18 Morning vs. evening chronotype; LUSC cis rs4253772 0.938 rs78336060 chr22:46641597 C/T cg09491104 chr22:46646882 C22orf40 -0.63 -6.52 -0.34 2.57e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg13206674 chr6:150067644 NUP43 0.59 9.6 0.47 1.94e-19 Lung cancer; LUSC cis rs4319547 0.619 rs7973869 chr12:122874284 G/C cg23029597 chr12:123009494 RSRC2 -0.74 -9.33 -0.45 1.54e-18 Body mass index; LUSC cis rs17255340 0.520 rs1170513 chr6:84008588 C/T cg08257003 chr6:84140564 ME1 0.32 7.82 0.39 7.22e-14 Platelet-derived growth factor BB levels; LUSC cis rs4363385 0.719 rs2066005 chr1:152923113 G/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.16 -0.36 5.12e-12 Inflammatory skin disease; LUSC trans rs561341 0.941 rs112569713 chr17:30271738 C/T cg27661571 chr11:113659931 NA -0.59 -7.18 -0.37 4.61e-12 Hip circumference adjusted for BMI; LUSC cis rs4654899 0.802 rs115818417 chr1:21200411 C/T cg01072550 chr1:21505969 NA -0.51 -7.59 -0.38 3.29e-13 Superior frontal gyrus grey matter volume; LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg22907277 chr7:1156413 C7orf50 0.49 7.52 0.38 5.21e-13 Longevity;Endometriosis; LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg20295408 chr7:1910781 MAD1L1 -0.48 -6.75 -0.35 6.39e-11 Bipolar disorder and schizophrenia; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg04398603 chr3:9439238 SETD5;LOC440944 0.37 6.07 0.32 3.45e-9 Asthma; LUSC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg09904177 chr6:26538194 HMGN4 -0.53 -6.18 -0.32 1.91e-9 Intelligence (multi-trait analysis); LUSC cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.13 -0.36 6.12e-12 Menarche (age at onset); LUSC cis rs9388451 0.839 rs9321054 chr6:126079968 A/G cg05901451 chr6:126070800 HEY2 0.96 19.31 0.73 2.48e-56 Brugada syndrome; LUSC cis rs970548 0.688 rs2082109 chr10:45931102 T/C cg23750895 chr10:46321377 AGAP4 -0.55 -5.71 -0.3 2.51e-8 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg06784218 chr1:46089804 CCDC17 -0.47 -9.11 -0.45 7.73e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4356932 0.691 rs4859581 chr4:76906974 A/G cg00809888 chr4:76862425 NAAA 0.37 6.12 0.32 2.61e-9 Blood protein levels; LUSC cis rs887829 0.694 rs869283 chr2:234626287 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.31 -0.37 1.99e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC trans rs7939886 0.920 rs12221615 chr11:55999950 G/C cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg15117754 chr3:10150083 C3orf24 0.44 5.65 0.3 3.46e-8 Alzheimer's disease; LUSC cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg09479241 chr17:27052676 TLCD1 0.43 5.96 0.31 6.29e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg09267113 chr7:98030324 BAIAP2L1 0.39 5.87 0.31 1.08e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs17401966 0.931 rs10864448 chr1:10277497 A/T cg19773385 chr1:10388646 KIF1B -0.57 -9.48 -0.46 5.08e-19 Hepatocellular carcinoma; LUSC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg09035930 chr12:129282057 SLC15A4 0.66 13.35 0.59 7.04e-33 Systemic lupus erythematosus; LUSC trans rs11098499 0.820 rs6534140 chr4:120455311 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg17178900 chr1:205818956 PM20D1 0.51 8.09 0.4 1.14e-14 Menarche (age at onset); LUSC cis rs2742234 0.590 rs2115817 chr10:43686552 C/T cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs11098499 0.863 rs1480939 chr4:120456927 T/C cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC cis rs4356932 1.000 rs7683657 chr4:76962643 T/C cg00809888 chr4:76862425 NAAA 0.36 6.13 0.32 2.5e-9 Blood protein levels; LUSC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg24250549 chr1:154909240 PMVK 0.56 8.97 0.44 2.24e-17 Prostate cancer; LUSC cis rs1775715 0.707 rs2799019 chr10:32142850 C/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.21 0.32 1.55e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6669072 0.527 rs10801831 chr1:91272391 T/A cg08895590 chr1:91227319 NA -0.27 -5.81 -0.3 1.48e-8 Cognitive function; LUSC cis rs5758659 0.935 rs134879 chr22:42664201 A/C cg04733989 chr22:42467013 NAGA 0.4 6.46 0.33 3.68e-10 Cognitive function; LUSC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -11.2 -0.52 6.22e-25 Hemoglobin concentration; LUSC cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.26 34.26 0.88 2.47e-111 Chronic sinus infection; LUSC cis rs1729951 0.575 rs2163896 chr3:136691177 G/A cg12473912 chr3:136751656 NA 0.39 6.81 0.35 4.6e-11 Neuroticism; LUSC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg12963246 chr6:28129442 ZNF389 0.49 7.14 0.36 5.76e-12 Parkinson's disease; LUSC cis rs6580649 0.941 rs1793931 chr12:48396505 G/T cg05342945 chr12:48394962 COL2A1 -0.45 -6.01 -0.31 4.94e-9 Lung cancer; LUSC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg11764359 chr7:65958608 NA 0.55 7.18 0.37 4.51e-12 Aortic root size; LUSC trans rs1998174 0.509 rs6425454 chr1:171817435 A/C cg13482142 chr2:234261155 NA 0.42 6.05 0.31 3.82e-9 Platelet distribution width; LUSC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg09365446 chr1:150670422 GOLPH3L 0.47 7.05 0.36 1.02e-11 Melanoma; LUSC cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg23029597 chr12:123009494 RSRC2 -0.71 -9.74 -0.47 6.68e-20 Body mass index; LUSC cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg18132916 chr6:79620363 NA -0.38 -5.81 -0.3 1.44e-8 Intelligence (multi-trait analysis); LUSC cis rs6977660 0.943 rs12668201 chr7:19831610 A/C cg05791153 chr7:19748676 TWISTNB -0.56 -6.34 -0.33 7.39e-10 Thyroid stimulating hormone; LUSC cis rs7572644 0.699 rs7595986 chr2:28085311 G/A cg27432699 chr2:27873401 GPN1 -0.51 -6.97 -0.36 1.75e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2486288 0.656 rs8039352 chr15:45551790 A/G cg14582100 chr15:45693742 SPATA5L1 -0.41 -7.36 -0.37 1.44e-12 Glomerular filtration rate; LUSC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg16393715 chr7:1948819 MAD1L1 0.37 6.22 0.32 1.52e-9 Bipolar disorder and schizophrenia; LUSC cis rs9420 0.961 rs11229148 chr11:57621460 A/T cg02958346 chr11:57425731 CLP1 -0.43 -6.26 -0.32 1.2e-9 Schizophrenia; LUSC cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.05e-43 Bladder cancer; LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg25072359 chr17:41440525 NA 0.66 9.49 0.46 4.49e-19 Menopause (age at onset); LUSC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.39 0.53 1.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs992157 0.932 rs56109829 chr2:219149740 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.54 8.33 0.41 2.13e-15 Colorectal cancer; LUSC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -6.77 -0.35 5.81e-11 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg06238570 chr21:40685208 BRWD1 0.47 7.16 0.36 5.2e-12 Cognitive function; LUSC cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg06064525 chr11:970664 AP2A2 -0.47 -10.06 -0.48 5.8e-21 Alzheimer's disease (late onset); LUSC cis rs73206853 0.764 rs55823622 chr12:110781628 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.43 0.33 4.37e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg03517284 chr6:25882590 NA -0.53 -8.83 -0.44 5.86e-17 Intelligence (multi-trait analysis); LUSC cis rs10203711 0.933 rs4994752 chr2:239567309 C/A cg14580085 chr2:239553406 NA 0.42 7.1 0.36 7.48e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs250677 1.000 rs250677 chr5:148433549 T/C cg23229984 chr5:148520753 ABLIM3 0.37 6.01 0.31 4.76e-9 Breast cancer; LUSC cis rs9309473 0.513 rs62149782 chr2:73819028 G/C cg20560298 chr2:73613845 ALMS1 -0.5 -6.02 -0.31 4.62e-9 Metabolite levels; LUSC cis rs469568 0.869 rs340124 chr5:178686590 C/T cg08999896 chr5:178685787 ADAMTS2 -0.3 -6.5 -0.34 2.88e-10 Stroke (pediatric); LUSC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.9 0.35 2.58e-11 Intelligence (multi-trait analysis); LUSC cis rs7107174 0.892 rs2512529 chr11:77977351 C/T cg02023728 chr11:77925099 USP35 0.48 6.73 0.35 7.36e-11 Testicular germ cell tumor; LUSC cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg26924012 chr15:45694286 SPATA5L1 1.12 20.31 0.74 2.75e-60 Homoarginine levels; LUSC cis rs6714710 0.603 rs6738389 chr2:98386731 A/G cg26665480 chr2:98280029 ACTR1B 0.6 8.81 0.43 7.07e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs1994135 0.669 rs11052746 chr12:33697473 A/C cg13010199 chr12:38710504 ALG10B -0.48 -6.62 -0.34 1.39e-10 Resting heart rate; LUSC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg11812906 chr14:75593930 NEK9 0.66 11.36 0.53 1.59e-25 Height; LUSC cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg23711669 chr6:146136114 FBXO30 0.75 13.38 0.59 5.42e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg11965913 chr1:205819406 PM20D1 0.89 17.42 0.69 8e-49 Menarche (age at onset); LUSC cis rs13631 0.965 rs9411307 chr9:139994947 C/T cg03717367 chr9:139980219 LOC100289341;MAN1B1 0.55 10.14 0.49 3.06e-21 Cerebrospinal fluid biomarker levels; LUSC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg20701182 chr2:24300061 SF3B14 0.9 11.63 0.54 1.77e-26 Lymphocyte counts; LUSC cis rs12760731 0.720 rs10913544 chr1:178350980 C/T cg00404053 chr1:178313656 RASAL2 0.58 6.06 0.31 3.76e-9 Obesity-related traits; LUSC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg23625390 chr15:77176239 SCAPER 0.48 7.48 0.38 6.53e-13 Blood metabolite levels; LUSC cis rs4664308 0.618 rs4665138 chr2:160890427 C/T cg03641300 chr2:160917029 PLA2R1 -0.49 -8.0 -0.4 2.07e-14 Idiopathic membranous nephropathy; LUSC cis rs7100689 0.784 rs7089058 chr10:82071263 T/C cg00277334 chr10:82204260 NA -0.54 -7.55 -0.38 4.07e-13 Post bronchodilator FEV1; LUSC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.39 6.07 0.32 3.46e-9 Platelet count; LUSC cis rs1691799 0.867 rs1168347 chr12:66757303 T/C cg16791601 chr12:66731901 HELB -0.72 -12.47 -0.56 1.4e-29 White blood cell count (basophil); LUSC cis rs4253772 0.938 rs41378347 chr22:46636976 G/A cg09491104 chr22:46646882 C22orf40 -0.59 -6.54 -0.34 2.27e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs3812762 0.783 rs34524863 chr11:8777408 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.36 -5.91 -0.31 8.33e-9 Hypospadias; LUSC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.07 -0.36 8.94e-12 Colorectal cancer; LUSC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg15212455 chr7:39170539 POU6F2 0.68 11.5 0.53 5.06e-26 IgG glycosylation; LUSC trans rs6461503 0.644 rs916789 chr7:20572530 A/C cg16873684 chr2:201828587 ORC2L 0.36 6.22 0.32 1.48e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.49 0.5 1.86e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.41 6.56 0.34 2.01e-10 Bone mineral density (hip);Bone mineral density; LUSC cis rs1784581 0.588 rs9885762 chr6:162411954 G/A cg17173639 chr6:162384350 PARK2 0.57 9.87 0.48 2.4e-20 Itch intensity from mosquito bite; LUSC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg06634786 chr22:41940651 POLR3H -0.55 -6.38 -0.33 5.84e-10 Vitiligo; LUSC cis rs7071206 0.947 rs11002226 chr10:79399656 T/A cg07817648 chr10:79422355 NA -0.58 -7.45 -0.38 7.99e-13 Bone mineral density; LUSC cis rs6504340 0.739 rs1529334 chr17:46671792 C/T cg09704116 chr17:46666958 LOC404266 0.35 6.34 0.33 7.4e-10 Primary tooth development (number of teeth); LUSC cis rs9646944 0.501 rs11465736 chr2:103067930 C/T cg20060108 chr2:102954350 IL1RL1 0.47 6.31 0.33 8.85e-10 Blood protein levels; LUSC cis rs472402 0.580 rs10060745 chr5:6658003 T/C cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.46 -6.68 -0.34 1.02e-10 Response to amphetamines; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg11494091 chr17:61959527 GH2 0.64 13.37 0.59 5.97e-33 Prudent dietary pattern; LUSC cis rs7011049 1.000 rs11993171 chr8:53832898 C/A cg26025543 chr8:53854495 NA 0.51 6.28 0.32 1.05e-9 Systolic blood pressure; LUSC cis rs11605275 0.581 rs11606785 chr11:20030430 A/C cg14835545 chr11:20032148 NAV2 -0.77 -6.55 -0.34 2.17e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg08048268 chr3:133502702 NA 0.34 6.63 0.34 1.39e-10 Alcohol consumption (transferrin glycosylation); LUSC cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC cis rs7107174 1.000 rs2510055 chr11:77961912 C/T cg02023728 chr11:77925099 USP35 0.51 7.12 0.36 6.74e-12 Testicular germ cell tumor; LUSC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg09904177 chr6:26538194 HMGN4 0.43 6.41 0.33 4.82e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7582720 0.887 rs72934589 chr2:204017937 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 8.78 0.43 8.34e-17 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg11764359 chr7:65958608 NA 0.68 10.88 0.51 8.15e-24 Aortic root size; LUSC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 11.46 0.53 7.15e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg18402987 chr7:1209562 NA 0.68 7.27 0.37 2.49e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6598955 0.671 rs11579630 chr1:26612297 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.95 -0.44 2.52e-17 Obesity-related traits; LUSC cis rs13064411 0.696 rs3732803 chr3:113211957 T/C cg18753928 chr3:113234510 CCDC52 -0.54 -8.23 -0.41 4.16e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs4595586 0.545 rs2388179 chr12:39364036 T/A cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg06877462 chr1:205807181 PM20D1 -0.32 -5.9 -0.31 8.73e-9 Monocyte percentage of white cells; LUSC trans rs35110281 0.744 rs230644 chr21:44917183 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.58 -9.57 -0.46 2.48e-19 Mean corpuscular volume; LUSC cis rs9467773 0.595 rs3799379 chr6:26404694 C/T cg09904177 chr6:26538194 HMGN4 -0.54 -8.05 -0.4 1.5e-14 Intelligence (multi-trait analysis); LUSC cis rs9926296 0.593 rs6500456 chr16:89888341 T/C cg04287289 chr16:89883240 FANCA 0.56 8.68 0.43 1.8e-16 Vitiligo; LUSC cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg24692254 chr21:30365293 RNF160 -0.8 -14.35 -0.62 1e-36 Dental caries; LUSC cis rs2073300 0.609 rs6137907 chr20:23344511 C/T cg12062639 chr20:23401060 NAPB 0.96 8.01 0.4 1.94e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs208520 0.690 rs176289 chr6:66766522 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -16.8 -0.68 2.51e-46 Exhaled nitric oxide output; LUSC cis rs1298908 0.639 rs2993763 chr10:82033594 G/A cg01528321 chr10:82214614 TSPAN14 0.58 8.49 0.42 6.9e-16 Diabetic kidney disease; LUSC cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg23649088 chr2:200775458 C2orf69 0.5 6.83 0.35 4.15e-11 Schizophrenia; LUSC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -8.54 -0.42 4.81e-16 Hemoglobin concentration; LUSC cis rs6752107 0.503 rs2304776 chr2:234227693 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 7.06 0.36 9.44e-12 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg19920283 chr7:105172520 RINT1 0.6 6.35 0.33 7.01e-10 Bipolar disorder (body mass index interaction); LUSC cis rs892961 0.899 rs66749226 chr17:75412826 G/A cg05865280 chr17:75406074 SEPT9 0.45 9.52 0.46 3.71e-19 Airflow obstruction; LUSC cis rs3768617 0.510 rs3768629 chr1:183074582 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.8 0.51 1.65e-23 Fuchs's corneal dystrophy; LUSC cis rs7937682 0.889 rs7948236 chr11:111499933 C/A cg19812747 chr11:111475976 SIK2 -0.52 -7.29 -0.37 2.23e-12 Primary sclerosing cholangitis; LUSC cis rs8180040 0.966 rs11711824 chr3:47468261 C/T cg27129171 chr3:47204927 SETD2 0.69 11.84 0.54 3e-27 Colorectal cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg05731183 chr15:68132796 NA 0.55 8.31 0.41 2.49e-15 Triglycerides; LUSC trans rs2204008 0.754 rs11181244 chr12:38302454 T/C cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Bladder cancer; LUSC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg08773314 chr2:239334832 ASB1 0.38 6.92 0.35 2.28e-11 Multiple system atrophy; LUSC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg23422044 chr7:1970798 MAD1L1 -0.64 -7.26 -0.37 2.8e-12 Bipolar disorder; LUSC cis rs12545109 0.800 rs1440747 chr8:57417924 G/T cg09654669 chr8:57350985 NA 0.5 6.53 0.34 2.44e-10 Obesity-related traits; LUSC cis rs11997175 0.524 rs12164218 chr8:33669658 G/C ch.8.33884649F chr8:33765107 NA 0.46 6.41 0.33 5.1e-10 Body mass index; LUSC cis rs6500395 1.000 rs1224 chr16:48572817 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.7 0.34 8.93e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6977660 0.714 rs10486365 chr7:19801364 A/G cg07541023 chr7:19748670 TWISTNB 0.6 6.47 0.33 3.57e-10 Thyroid stimulating hormone; LUSC cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg05294307 chr14:35346193 BAZ1A -0.61 -7.34 -0.37 1.65e-12 Psoriasis; LUSC cis rs9341808 0.718 rs12208016 chr6:80823563 G/A cg08355045 chr6:80787529 NA 0.56 9.85 0.47 2.85e-20 Sitting height ratio; LUSC cis rs6598955 0.670 rs11247892 chr1:26592727 A/G cg04990556 chr1:26633338 UBXN11 -0.8 -14.69 -0.63 4.94e-38 Obesity-related traits; LUSC cis rs12421382 0.659 rs57978015 chr11:109385473 T/C cg11473876 chr11:109292803 C11orf87 0.41 6.73 0.35 7.35e-11 Schizophrenia; LUSC cis rs9905704 0.647 rs8077332 chr17:57105223 A/G cg12560992 chr17:57184187 TRIM37 0.62 10.38 0.49 4.48e-22 Testicular germ cell tumor; LUSC cis rs9311676 0.656 rs6800514 chr3:58358717 C/T cg13750441 chr3:58318267 PXK 0.36 6.72 0.35 7.74e-11 Systemic lupus erythematosus; LUSC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg13395646 chr4:1353034 KIAA1530 -0.64 -10.08 -0.48 4.83e-21 Obesity-related traits; LUSC cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg05340658 chr4:99064831 C4orf37 0.68 11.57 0.53 2.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg06219351 chr7:158114137 PTPRN2 -0.54 -9.85 -0.47 2.89e-20 Calcium levels; LUSC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg02038168 chr22:39784481 NA 0.47 7.4 0.38 1.1e-12 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg04450456 chr4:17643702 FAM184B 0.35 5.81 0.3 1.47e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs71403859 0.614 rs12935422 chr16:71664225 T/A cg08717414 chr16:71523259 ZNF19 -0.71 -8.01 -0.4 1.93e-14 Post bronchodilator FEV1; LUSC trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg15704280 chr7:45808275 SEPT13 0.98 15.85 0.66 1.38e-42 Height; LUSC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.68 -0.39 1.83e-13 Breast cancer; LUSC trans rs2679649 1.000 rs2679647 chr6:122351503 C/T cg00167820 chr8:131663355 NA 0.54 6.35 0.33 6.96e-10 Subcutaneous adipose tissue; LUSC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg21770322 chr7:97807741 LMTK2 -0.41 -7.22 -0.37 3.52e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg10295955 chr4:187884368 NA -1.03 -22.81 -0.78 4.31e-70 Lobe attachment (rater-scored or self-reported); LUSC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg14440974 chr22:39074834 NA -0.37 -6.14 -0.32 2.34e-9 Menopause (age at onset); LUSC cis rs67696533 0.600 rs6119879 chr20:31105389 C/T cg13636640 chr20:31349939 DNMT3B 0.47 6.38 0.33 5.83e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs25645 0.830 rs4072639 chr17:38189049 G/A cg17467752 chr17:38218738 THRA -0.56 -8.09 -0.4 1.13e-14 Myeloid white cell count; LUSC cis rs1448094 0.802 rs11513957 chr12:86435551 C/T cg02569458 chr12:86230093 RASSF9 0.47 7.46 0.38 7.39e-13 Major depressive disorder; LUSC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg21984481 chr17:79567631 NPLOC4 -0.68 -14.17 -0.61 5e-36 Eye color traits; LUSC cis rs4319547 0.695 rs10846699 chr12:122853073 A/G cg05707623 chr12:122985044 ZCCHC8 0.66 8.33 0.41 2.16e-15 Body mass index; LUSC cis rs7107174 0.581 rs11237485 chr11:78126011 G/A cg02023728 chr11:77925099 USP35 0.42 6.2 0.32 1.63e-9 Testicular germ cell tumor; LUSC cis rs7582720 1.000 rs6725887 chr2:203745885 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.81 -8.68 -0.43 1.82e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs3125734 0.633 rs4561099 chr10:64041163 T/C cg09941381 chr10:64027924 RTKN2 -0.38 -6.92 -0.35 2.28e-11 Rheumatoid arthritis; LUSC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.48 -6.44 -0.33 4.09e-10 Tonsillectomy; LUSC cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg23788917 chr6:8435910 SLC35B3 -0.49 -7.29 -0.37 2.29e-12 Motion sickness; LUSC cis rs416603 0.967 rs11644184 chr16:11365104 G/A cg00044050 chr16:11439710 C16orf75 -0.68 -12.22 -0.56 1.26e-28 Type 1 diabetes; LUSC trans rs9329221 0.686 rs13264580 chr8:10250699 C/T cg06636001 chr8:8085503 FLJ10661 0.57 7.68 0.39 1.83e-13 Neuroticism; LUSC cis rs6582630 0.638 rs61931383 chr12:38513845 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.54 -0.34 2.36e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs10927875 0.864 rs6674071 chr1:16144855 G/C cg21385522 chr1:16154831 NA -0.96 -16.33 -0.67 1.85e-44 Dilated cardiomyopathy; LUSC cis rs2012796 0.956 rs7146802 chr14:81820515 A/G cg02996355 chr14:81879375 NA 0.51 7.34 0.37 1.65e-12 Night sleep phenotypes; LUSC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg00857998 chr1:205179979 DSTYK 0.63 9.79 0.47 4.45e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg23758822 chr17:41437982 NA 1.05 20.2 0.74 7.77e-60 Menopause (age at onset); LUSC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg05535760 chr7:792225 HEATR2 0.81 9.44 0.46 6.54e-19 Cerebrospinal P-tau181p levels; LUSC cis rs4148883 0.689 rs1311621 chr4:100014018 T/C cg12011299 chr4:100065546 ADH4 0.49 8.01 0.4 1.97e-14 Alcohol dependence; LUSC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg01448562 chr3:133502909 NA -0.66 -10.81 -0.51 1.47e-23 Iron status biomarkers; LUSC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg14582100 chr15:45693742 SPATA5L1 -0.58 -10.65 -0.5 5.27e-23 Homoarginine levels; LUSC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.41 6.27 0.32 1.09e-9 Platelet count; LUSC cis rs9611565 0.580 rs5758449 chr22:42140160 C/T cg03806693 chr22:41940476 POLR3H 0.85 12.22 0.56 1.25e-28 Vitiligo; LUSC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg21433313 chr16:3507492 NAT15 0.4 5.65 0.3 3.49e-8 Body mass index (adult); LUSC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg04362960 chr10:104952993 NT5C2 0.58 8.32 0.41 2.29e-15 Arsenic metabolism; LUSC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg25019033 chr10:957182 NA -0.5 -5.7 -0.3 2.64e-8 Eosinophil percentage of granulocytes; LUSC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC trans rs7916697 0.626 rs3858144 chr10:70011354 A/G cg04882175 chr6:131122610 NA -0.51 -6.79 -0.35 5.26e-11 Optic disc area; LUSC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg00701064 chr4:6280414 WFS1 0.58 14.61 0.62 9.98e-38 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs13040088 0.872 rs13039291 chr20:61572760 C/T cg23096297 chr20:61557774 DIDO1 0.81 10.59 0.5 8.83e-23 Menopause (age at onset); LUSC cis rs11169552 0.510 rs55877451 chr12:50987378 G/A cg12884762 chr12:50931848 DIP2B -0.31 -5.64 -0.3 3.58e-8 Colorectal cancer; LUSC cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.12e-12 Motion sickness; LUSC cis rs7432375 0.610 rs56695781 chr3:136510601 G/T cg12473912 chr3:136751656 NA 0.32 5.68 0.3 2.96e-8 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs11158026 0.603 rs66769866 chr14:55446153 C/T cg04306507 chr14:55594613 LGALS3 0.4 7.45 0.38 7.84e-13 Parkinson's disease; LUSC cis rs11155671 0.530 rs9371215 chr6:150194298 C/T cg13206674 chr6:150067644 NUP43 0.45 6.79 0.35 5.02e-11 Testicular germ cell tumor; LUSC trans rs61931739 0.534 rs1384860 chr12:34045388 T/C cg13010199 chr12:38710504 ALG10B 0.53 7.92 0.4 3.45e-14 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.24 0.37 3.16e-12 Bipolar disorder; LUSC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg08917208 chr2:24149416 ATAD2B 0.53 5.87 0.31 1.03e-8 Lymphocyte counts; LUSC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.38 -5.75 -0.3 2e-8 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.22 0.64 4.18e-40 Bladder cancer; LUSC cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 6.34 0.33 7.47e-10 Rheumatoid arthritis; LUSC cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg21535247 chr6:8435926 SLC35B3 0.57 9.0 0.44 1.69e-17 Motion sickness; LUSC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg13442820 chr19:1672531 NA 0.68 6.42 0.33 4.81e-10 Body mass index; LUSC cis rs2806561 0.828 rs604030 chr1:23518227 T/C cg19743168 chr1:23544995 NA 0.4 8.06 0.4 1.34e-14 Height; LUSC trans rs3733585 0.699 rs7694997 chr4:9947811 A/G cg26043149 chr18:55253948 FECH -0.44 -6.8 -0.35 4.77e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg11752832 chr7:134001865 SLC35B4 0.56 8.77 0.43 9.42e-17 Mean platelet volume; LUSC trans rs11098499 0.821 rs3775852 chr4:120454556 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg22907277 chr7:1156413 C7orf50 0.52 7.73 0.39 1.28e-13 Longevity;Endometriosis; LUSC trans rs1005277 0.579 rs1740745 chr10:38520056 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.51 -0.46 3.89e-19 Extrinsic epigenetic age acceleration; LUSC cis rs4343996 0.870 rs6974075 chr7:3392071 A/G cg21248987 chr7:3385318 SDK1 -0.42 -7.15 -0.36 5.37e-12 Motion sickness; LUSC cis rs35146811 0.731 rs2257213 chr7:99810113 T/C cg22906224 chr7:99728672 NA -0.5 -6.89 -0.35 2.8e-11 Coronary artery disease; LUSC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg08470875 chr2:26401718 FAM59B -0.66 -8.86 -0.44 4.75e-17 Gut microbiome composition (summer); LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg22920501 chr2:26401640 FAM59B -0.78 -11.28 -0.53 3.15e-25 Gut microbiome composition (summer); LUSC cis rs2455601 0.882 rs11042115 chr11:8926679 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.83 -0.35 4.1e-11 Schizophrenia; LUSC cis rs9325144 0.560 rs7980635 chr12:38668355 G/T cg13010199 chr12:38710504 ALG10B -0.51 -7.67 -0.39 1.87e-13 Morning vs. evening chronotype; LUSC cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.78 7.71 0.39 1.47e-13 Initial pursuit acceleration; LUSC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg01973587 chr1:228161476 NA -0.41 -7.4 -0.38 1.15e-12 Diastolic blood pressure; LUSC cis rs1538970 0.810 rs12067642 chr1:45927517 G/T cg05343316 chr1:45956843 TESK2 0.68 9.45 0.46 6.16e-19 Platelet count; LUSC cis rs7189233 0.550 rs17193176 chr16:53518228 T/C cg09728985 chr16:53543985 NA -0.31 -5.9 -0.31 9.01e-9 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.596 rs10773002 chr12:123746961 A/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.34 6.05 0.31 3.79e-9 Neutrophil percentage of white cells; LUSC cis rs9914988 0.943 rs2242345 chr17:27185827 C/T cg09479241 chr17:27052676 TLCD1 -0.42 -5.7 -0.3 2.61e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg03240473 chr21:43526662 UMODL1;C21orf128 0.44 7.16 0.36 5.15e-12 IgG glycosylation; LUSC cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.53 0.57 8.85e-30 Motion sickness; LUSC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11644478 chr21:40555479 PSMG1 -0.59 -9.3 -0.45 1.91e-18 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24695950 chr2:162364264 NA 0.43 6.32 0.33 8.58e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs61931739 0.513 rs1463634 chr12:33899621 A/G cg13010199 chr12:38710504 ALG10B 0.48 7.56 0.38 3.82e-13 Morning vs. evening chronotype; LUSC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg00049323 chr5:472564 LOC25845 -0.42 -6.4 -0.33 5.37e-10 Cystic fibrosis severity; LUSC cis rs9611519 0.894 rs4821998 chr22:41468273 C/G cg03806693 chr22:41940476 POLR3H -0.55 -7.51 -0.38 5.5e-13 Neuroticism; LUSC trans rs7826238 0.564 rs2921053 chr8:8319963 G/C cg27411982 chr8:10470053 RP1L1 0.39 6.23 0.32 1.38e-9 Systolic blood pressure; LUSC cis rs34233420 1 rs34233420 chr17:38004929 GATTT/G cg10909506 chr17:38081995 ORMDL3 0.33 5.7 0.3 2.68e-8 Lymphocyte counts; LUSC cis rs2354432 0.607 rs11587707 chr1:146707186 T/C cg25205988 chr1:146714368 CHD1L -1.02 -8.96 -0.44 2.35e-17 Mitochondrial DNA levels; LUSC cis rs7193541 0.826 rs56143602 chr16:74694692 T/C cg01733217 chr16:74700730 RFWD3 0.86 15.02 0.63 2.51e-39 Multiple myeloma; LUSC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg23711669 chr6:146136114 FBXO30 -0.91 -17.44 -0.69 6.92e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.817 rs55891651 chr8:58167600 C/T cg22535103 chr8:58192502 C8orf71 -0.77 -9.95 -0.48 1.31e-20 Developmental language disorder (linguistic errors); LUSC cis rs7100689 0.622 rs7897994 chr10:82133304 T/G cg01528321 chr10:82214614 TSPAN14 0.86 13.08 0.58 7.25e-32 Post bronchodilator FEV1; LUSC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -8.78 -0.43 8.41e-17 Bipolar disorder and schizophrenia; LUSC cis rs1865760 0.713 rs2013063 chr6:25994098 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.08e-11 Height; LUSC cis rs11630290 0.736 rs28621516 chr15:64156314 G/A cg12036633 chr15:63758958 NA -0.64 -6.98 -0.36 1.61e-11 Iris characteristics; LUSC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg14664628 chr15:75095509 CSK 0.55 8.41 0.42 1.18e-15 Breast cancer; LUSC cis rs11122272 0.735 rs2739506 chr1:231529183 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.17 -0.49 2.5e-21 Hemoglobin concentration; LUSC cis rs9933309 1.000 rs9933309 chr16:88844932 A/G cg27661460 chr16:88844969 FAM38A 0.48 7.16 0.36 5.13e-12 Glycated hemoglobin levels; LUSC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg13531842 chr10:38383804 ZNF37A -0.44 -6.85 -0.35 3.62e-11 Extrinsic epigenetic age acceleration; LUSC cis rs2820315 0.867 rs2820322 chr1:201880300 T/C cg10061532 chr1:201886748 LMOD1 0.28 6.45 0.33 3.87e-10 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13398864 chr3:122920640 SEC22A 0.44 6.74 0.35 6.79e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.66 11.5 0.53 5.02e-26 Personality dimensions; LUSC cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg06064525 chr11:970664 AP2A2 -0.49 -10.81 -0.51 1.5e-23 Alzheimer's disease (late onset); LUSC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg19622623 chr12:86230825 RASSF9 -0.42 -5.97 -0.31 5.98e-9 Major depressive disorder; LUSC cis rs12618769 1.000 rs72825718 chr2:99247152 C/T cg10123293 chr2:99228465 UNC50 0.41 5.7 0.3 2.57e-8 Bipolar disorder; LUSC cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg08754478 chr10:133766260 PPP2R2D -0.61 -7.85 -0.39 5.62e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7927592 0.513 rs531163 chr11:68194496 A/G cg20283391 chr11:68216788 NA -0.5 -6.97 -0.36 1.71e-11 Total body bone mineral density; LUSC trans rs724744 0.742 rs714591 chr6:22360046 T/A cg13807341 chr11:118445984 ARCN1 -0.35 -5.97 -0.31 6.14e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg06713675 chr4:122721982 EXOSC9 -0.47 -8.26 -0.41 3.38e-15 Type 2 diabetes; LUSC cis rs6539267 0.516 rs17218455 chr12:106716441 C/T cg00173435 chr12:106696525 TCP11L2 0.6 7.24 0.37 3.17e-12 Tourette syndrome; LUSC cis rs4478858 0.775 rs12139418 chr1:31706352 T/C cg00250761 chr1:31883323 NA -0.36 -9.35 -0.46 1.34e-18 Alcohol dependence; LUSC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11890956 chr21:40555474 PSMG1 0.95 16.09 0.66 1.58e-43 Cognitive function; LUSC cis rs642803 0.551 rs1308020 chr11:65497558 G/A cg02870584 chr11:65547924 DKFZp761E198 0.44 6.02 0.31 4.54e-9 Urate levels; LUSC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg05623727 chr3:50126028 RBM5 0.32 5.96 0.31 6.24e-9 Intelligence (multi-trait analysis); LUSC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg24733560 chr20:60626293 TAF4 0.43 7.85 0.39 5.81e-14 Body mass index; LUSC cis rs17401966 0.931 rs1002076 chr1:10438892 G/A cg19773385 chr1:10388646 KIF1B -0.58 -9.72 -0.47 7.96e-20 Hepatocellular carcinoma; LUSC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.05 -0.36 1.02e-11 Colorectal cancer; LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg12564285 chr5:131593104 PDLIM4 0.5 8.9 0.44 3.6e-17 Acylcarnitine levels; LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg08888203 chr3:10149979 C3orf24 0.62 8.51 0.42 5.77e-16 Alzheimer's disease; LUSC trans rs7819412 0.668 rs4841507 chr8:11046394 C/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.14 -0.32 2.34e-9 Triglycerides; LUSC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg01097406 chr16:89675127 NA -0.35 -6.85 -0.35 3.57e-11 Vitiligo; LUSC cis rs10927875 0.501 rs9660676 chr1:16279041 C/T cg21385522 chr1:16154831 NA -0.89 -12.36 -0.56 3.65e-29 Dilated cardiomyopathy; LUSC cis rs950169 0.922 rs11633534 chr15:85124642 C/T cg17507749 chr15:85114479 UBE2QP1 0.69 8.87 0.44 4.5e-17 Schizophrenia; LUSC cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -8.29 -0.41 2.77e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9630182 0.561 rs11022781 chr11:13402409 C/T cg00234616 chr2:74740572 TLX2 -0.31 -6.27 -0.32 1.11e-9 Bone mineral density; LUSC cis rs920590 0.573 rs12547934 chr8:19680736 T/C cg03894339 chr8:19674705 INTS10 -0.45 -6.37 -0.33 6.26e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg21951975 chr1:209979733 IRF6 0.37 6.03 0.31 4.26e-9 Monobrow; LUSC cis rs3755132 1.000 rs3770460 chr2:15729268 C/T cg12888861 chr2:15731646 DDX1 -0.52 -7.52 -0.38 4.97e-13 Wilms tumor; LUSC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg17971929 chr21:40555470 PSMG1 -0.62 -10.27 -0.49 1.06e-21 Cognitive function; LUSC cis rs9302635 0.513 rs8050238 chr16:72154187 C/T cg01557791 chr16:72042693 DHODH -0.46 -6.08 -0.32 3.2e-9 Blood protein levels; LUSC cis rs7264396 0.790 rs6058294 chr20:34259396 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.68 -0.47 1.09e-19 Total cholesterol levels; LUSC cis rs1965732 0.958 rs6755529 chr2:3711972 C/T cg25251562 chr2:3704773 ALLC 0.39 6.93 0.35 2.12e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs8002861 0.935 rs1373903 chr13:44475514 G/T cg17145862 chr1:211918768 LPGAT1 0.23 6.07 0.32 3.44e-9 Leprosy; LUSC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg09365446 chr1:150670422 GOLPH3L 0.48 7.12 0.36 6.67e-12 Melanoma; LUSC cis rs754466 0.651 rs7895188 chr10:79623378 C/G cg17075019 chr10:79541650 NA 0.73 12.01 0.55 7.58e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs10435719 0.867 rs6999030 chr8:11795308 G/A cg06636001 chr8:8085503 FLJ10661 0.54 8.13 0.41 8.4e-15 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg03790207 chr6:42947109 PEX6 0.45 7.03 0.36 1.18e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs832540 0.902 rs194059 chr5:56197416 G/A cg20203395 chr5:56204925 C5orf35 -0.45 -6.59 -0.34 1.69e-10 Coronary artery disease; LUSC trans rs7618501 0.602 rs2526754 chr3:50125996 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.76 -0.47 6.01e-20 Intelligence (multi-trait analysis); LUSC cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg15848620 chr12:58087721 OS9 0.48 6.59 0.34 1.75e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs9462027 0.727 rs3798352 chr6:34734809 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.9 -0.31 8.69e-9 Systemic lupus erythematosus; LUSC cis rs4654899 0.865 rs6700459 chr1:21279396 T/C cg01072550 chr1:21505969 NA -0.49 -7.28 -0.37 2.44e-12 Superior frontal gyrus grey matter volume; LUSC cis rs2839186 0.869 rs17176513 chr21:47682428 A/G cg05896524 chr21:47604654 C21orf56 0.42 6.25 0.32 1.25e-9 Testicular germ cell tumor; LUSC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg20295408 chr7:1910781 MAD1L1 0.51 7.48 0.38 6.79e-13 Bipolar disorder and schizophrenia; LUSC cis rs425277 0.527 rs3107144 chr1:2045380 C/A cg12639453 chr1:2035780 PRKCZ -0.3 -6.3 -0.33 9.13e-10 Height; LUSC cis rs11122272 0.735 rs2808586 chr1:231515559 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.51 0.34 2.74e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4629710 0.592 rs11154622 chr6:131547578 C/T cg12700074 chr6:131571435 AKAP7 -0.36 -6.05 -0.31 3.92e-9 Multiple myeloma (IgH translocation); LUSC cis rs644799 0.526 rs506180 chr11:95623109 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.58 8.75 0.43 1.07e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg05043794 chr9:111880884 C9orf5 -0.34 -7.23 -0.37 3.33e-12 Menarche (age at onset); LUSC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.27 -0.32 1.11e-9 Total body bone mineral density; LUSC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.09 -16.92 -0.68 7.95e-47 Gut microbiome composition (summer); LUSC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.54 -9.72 -0.47 7.77e-20 Bipolar disorder; LUSC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg14983838 chr19:29218262 NA 0.58 6.8 0.35 4.82e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9311676 0.609 rs55646457 chr3:58415263 T/A cg26110898 chr3:58419937 PDHB 0.4 6.41 0.33 5.09e-10 Systemic lupus erythematosus; LUSC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg18681998 chr4:17616180 MED28 0.85 16.13 0.66 1.06e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg16680214 chr1:154839983 KCNN3 0.57 10.51 0.5 1.6e-22 Prostate cancer; LUSC trans rs1998174 0.509 rs2206543 chr1:171835493 A/G cg13482142 chr2:234261155 NA -0.43 -6.32 -0.33 8.47e-10 Platelet distribution width; LUSC cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg05347473 chr6:146136440 FBXO30 -0.43 -7.41 -0.38 1.02e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs11642862 1.000 rs11641321 chr16:30880319 G/A cg02466173 chr16:30829666 NA -0.69 -6.93 -0.35 2.24e-11 Tonsillectomy; LUSC trans rs11098499 0.698 rs4422403 chr4:120258194 C/T cg25214090 chr10:38739885 LOC399744 0.41 6.43 0.33 4.42e-10 Corneal astigmatism; LUSC cis rs11696845 0.776 rs6073538 chr20:43379264 A/C cg25301532 chr20:43378953 KCNK15 0.36 6.28 0.33 1.03e-9 Obesity-related traits; LUSC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg12927641 chr6:109611667 NA -0.36 -6.12 -0.32 2.69e-9 Reticulocyte fraction of red cells; LUSC cis rs7666738 0.518 rs13133925 chr4:98706398 G/T cg05340658 chr4:99064831 C4orf37 0.59 8.75 0.43 1.04e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs950776 0.616 rs12901300 chr15:78892952 G/A cg22563815 chr15:78856949 CHRNA5 0.26 6.26 0.32 1.19e-9 Sudden cardiac arrest; LUSC cis rs3768617 0.782 rs10911211 chr1:183022299 A/T ch.1.3577855R chr1:183094577 LAMC1 0.59 8.5 0.42 6.29e-16 Fuchs's corneal dystrophy; LUSC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg06634786 chr22:41940651 POLR3H -0.51 -5.99 -0.31 5.45e-9 Vitiligo; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg19165652 chr17:54671146 NOG -0.49 -6.63 -0.34 1.38e-10 Neuroticism; LUSC cis rs28647808 0.881 rs41316984 chr9:136259231 T/C cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC trans rs9650657 0.504 rs2409724 chr8:11041642 A/T cg15556689 chr8:8085844 FLJ10661 -0.56 -8.4 -0.42 1.26e-15 Neuroticism; LUSC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg15445000 chr17:37608096 MED1 0.38 6.63 0.34 1.34e-10 Glomerular filtration rate (creatinine); LUSC cis rs1882538 0.503 rs13240997 chr7:133135373 C/A cg10665199 chr7:133106180 EXOC4 0.61 8.18 0.41 5.83e-15 Intelligence (multi-trait analysis); LUSC cis rs447735 0.507 rs11645271 chr16:89729125 G/T cg06640241 chr16:89574553 SPG7 -0.4 -5.88 -0.31 1.02e-8 Hemoglobin concentration; LUSC cis rs7428496 0.510 rs13075259 chr3:142170600 C/A cg16271453 chr3:142027066 XRN1 -0.55 -9.42 -0.46 7.47e-19 Mean corpuscular hemoglobin; LUSC cis rs2011503 0.882 rs10423874 chr19:19359500 C/G cg11584989 chr19:19387371 SF4 0.62 7.39 0.38 1.16e-12 Bipolar disorder; LUSC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.37 5.8 0.3 1.54e-8 Menarche (age at onset); LUSC cis rs7208859 0.623 rs9899268 chr17:29150255 T/C cg13385521 chr17:29058706 SUZ12P 0.65 6.26 0.32 1.18e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1577917 1.000 rs12203493 chr6:86758642 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.77 -0.35 5.91e-11 Response to antipsychotic treatment; LUSC cis rs35146811 0.695 rs1623264 chr7:99811204 G/C cg22906224 chr7:99728672 NA -0.47 -6.56 -0.34 2.03e-10 Coronary artery disease; LUSC cis rs259282 0.519 rs259276 chr19:33160953 C/G cg22980127 chr19:33182716 NUDT19 -0.49 -6.3 -0.33 9.65e-10 Schizophrenia; LUSC cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg26373071 chr5:1325741 CLPTM1L 0.41 7.72 0.39 1.41e-13 Lung cancer; LUSC cis rs7267979 1.000 rs2184000 chr20:25395878 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.94 -0.74 8.36e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg22963979 chr7:1858916 MAD1L1 -0.73 -12.52 -0.57 9.78e-30 Bipolar disorder and schizophrenia; LUSC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11890956 chr21:40555474 PSMG1 -0.75 -11.65 -0.54 1.48e-26 Menarche (age at onset); LUSC cis rs16867321 0.901 rs768116 chr2:181511012 A/G cg23363182 chr2:181467187 NA -0.45 -5.91 -0.31 8.53e-9 Obesity; LUSC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg00409905 chr10:38381863 ZNF37A -0.38 -6.49 -0.33 3.17e-10 Extrinsic epigenetic age acceleration; LUSC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg22834771 chr12:69754056 YEATS4 -0.41 -5.82 -0.3 1.36e-8 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02986546 chr7:87505538 SLC25A40;DBF4 -0.44 -6.39 -0.33 5.64e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7903847 0.642 rs10786344 chr10:99165975 T/C cg20016023 chr10:99160130 RRP12 -0.3 -7.44 -0.38 8.68e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs67072384 1.000 rs12294368 chr11:72451239 G/A cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.47e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg17554472 chr22:41940697 POLR3H 0.47 5.8 0.3 1.53e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg18681998 chr4:17616180 MED28 0.87 15.74 0.65 3.84e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6754311 0.689 rs192822 chr2:136682274 A/T cg07169764 chr2:136633963 MCM6 0.54 7.62 0.38 2.66e-13 Mosquito bite size; LUSC cis rs9420 1.000 rs9420 chr11:57510294 A/G cg23127183 chr11:57508653 C11orf31 0.54 8.15 0.41 7.56e-15 Schizophrenia; LUSC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg23649088 chr2:200775458 C2orf69 0.53 7.23 0.37 3.26e-12 Schizophrenia; LUSC cis rs6964587 1.000 rs10225892 chr7:91671020 A/G cg17063962 chr7:91808500 NA 0.57 9.09 0.45 8.73e-18 Breast cancer; LUSC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2439831 0.681 rs528517 chr15:43612925 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.11 15.45 0.65 5.04e-41 Lung cancer in ever smokers; LUSC cis rs72781680 0.898 rs7563564 chr2:23993404 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs1371867 0.846 rs924057 chr8:101266157 A/G cg06002616 chr8:101225028 SPAG1 0.39 6.57 0.34 1.97e-10 Atrioventricular conduction; LUSC cis rs11190604 1.000 rs12354411 chr10:102294537 G/A cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg08807101 chr21:30365312 RNF160 -0.76 -13.45 -0.59 2.85e-33 Dental caries; LUSC cis rs6121246 0.865 rs6058421 chr20:30295013 G/C cg18721089 chr20:30220636 NA -0.35 -6.01 -0.31 4.91e-9 Mean corpuscular hemoglobin; LUSC cis rs17685 0.753 rs1637051 chr7:75730659 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.52 -7.83 -0.39 6.5e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.0 0.44 1.69e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg18404041 chr3:52824283 ITIH1 -0.55 -9.54 -0.46 3.05e-19 Bipolar disorder; LUSC cis rs77106637 1.000 rs76793820 chr11:72619860 G/A cg04827223 chr11:72435913 ARAP1 -0.71 -9.08 -0.45 9.39e-18 Type 2 diabetes; LUSC cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg08999081 chr20:33150536 PIGU 0.55 11.34 0.53 1.97e-25 Coronary artery disease; LUSC cis rs7592578 0.603 rs12476782 chr2:191472880 G/A cg11845111 chr2:191398756 TMEM194B -0.74 -9.88 -0.48 2.37e-20 Diastolic blood pressure; LUSC trans rs1532331 0.933 rs6451675 chr5:43110855 C/G cg02477305 chr13:23993013 SACS 0.36 6.32 0.33 8.13e-10 Menarche (age at onset); LUSC cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs1775715 0.737 rs2808028 chr10:32101189 G/A cg18675610 chr10:32216311 ARHGAP12 0.29 6.34 0.33 7.56e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg16606324 chr3:10149918 C3orf24 -0.46 -6.62 -0.34 1.42e-10 Alzheimer's disease; LUSC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg01416388 chr22:39784598 NA -0.46 -7.84 -0.39 6.3e-14 Intelligence (multi-trait analysis); LUSC trans rs853679 0.607 rs67101035 chr6:27798887 C/G cg01620082 chr3:125678407 NA -0.82 -7.24 -0.37 3.06e-12 Depression; LUSC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.48 9.42 0.46 7.63e-19 Monocyte percentage of white cells; LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg14004847 chr7:1930337 MAD1L1 -0.56 -8.75 -0.43 1.09e-16 Bipolar disorder and schizophrenia; LUSC cis rs9921222 0.786 rs3848365 chr16:374617 C/T cg02086790 chr16:375327 AXIN1 -0.38 -6.48 -0.33 3.26e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs216026 0.638 rs12312322 chr12:2771806 A/G cg19945202 chr12:2788847 CACNA1C -0.37 -5.72 -0.3 2.36e-8 Fractional exhaled nitric oxide (childhood); LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg03352830 chr11:487213 PTDSS2 0.68 8.61 0.43 2.91e-16 Body mass index; LUSC cis rs6121246 1.000 rs6121246 chr20:30433352 C/T cg18721089 chr20:30220636 NA -0.37 -6.33 -0.33 7.87e-10 Mean corpuscular hemoglobin; LUSC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.49 9.55 0.46 2.87e-19 Eosinophil percentage of white cells; LUSC cis rs698833 0.501 rs12473699 chr2:44507673 G/A cg04920474 chr2:44395004 PPM1B 0.56 9.34 0.46 1.39e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs11718455 0.960 rs3843373 chr3:44011053 C/T cg08738300 chr3:44038990 NA -0.72 -9.45 -0.46 6.08e-19 Coronary artery disease; LUSC cis rs3020736 0.500 rs5996110 chr22:42493767 A/G cg04733989 chr22:42467013 NAGA -0.61 -9.47 -0.46 5.21e-19 Autism spectrum disorder or schizophrenia; LUSC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg19346786 chr7:2764209 NA -0.43 -7.25 -0.37 2.85e-12 Height; LUSC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg04450456 chr4:17643702 FAM184B 0.38 6.52 0.34 2.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs116161686 0.521 rs701941 chr1:210439529 G/A cg22029157 chr1:209979665 IRF6 0.54 6.14 0.32 2.35e-9 Coronary artery disease; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25135922 chr1:226497286 LIN9 0.71 6.08 0.32 3.31e-9 Cognitive performance; LUSC cis rs7523273 0.925 rs2745977 chr1:208017360 C/A cg22525895 chr1:207977042 MIR29B2 -0.4 -6.07 -0.32 3.51e-9 Schizophrenia; LUSC cis rs67072384 1.000 rs72966113 chr11:72450970 C/T cg04827223 chr11:72435913 ARAP1 -0.78 -6.71 -0.34 8.47e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs4423214 0.765 rs2002064 chr11:71163420 A/G cg05163923 chr11:71159392 DHCR7 -0.75 -9.79 -0.47 4.63e-20 Vitamin D levels; LUSC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg03354898 chr7:1950403 MAD1L1 -0.35 -6.89 -0.35 2.73e-11 Schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24185116 chr15:52044314 LYSMD2;TMOD2 -0.41 -6.8 -0.35 4.7e-11 Electrocardiographic conduction measures; LUSC cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.76 -0.35 6.29e-11 Monocyte percentage of white cells; LUSC cis rs11158026 0.757 rs7157085 chr14:55444746 G/A cg04306507 chr14:55594613 LGALS3 0.38 7.47 0.38 6.85e-13 Parkinson's disease; LUSC cis rs36093844 0.848 rs55836023 chr11:85566157 A/G cg25872744 chr11:85566296 CCDC83 -0.51 -7.01 -0.36 1.32e-11 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs2227564 0.620 rs3812637 chr10:75568846 C/T cg23231163 chr10:75533350 FUT11 -0.44 -6.38 -0.33 5.94e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4853012 0.887 rs2280644 chr2:74358411 G/A cg20891558 chr2:74357851 NA 0.85 15.73 0.65 4.07e-42 Gestational age at birth (maternal effect); LUSC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg06363034 chr20:62225388 GMEB2 -0.44 -7.2 -0.37 4.01e-12 Glioblastoma; LUSC cis rs2562456 0.793 rs2562420 chr19:21631305 T/A cg00806126 chr19:22604979 ZNF98 0.37 5.85 0.3 1.19e-8 Pain; LUSC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.61 -0.34 1.52e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg10621924 chr7:39171070 POU6F2 0.48 7.62 0.38 2.68e-13 IgG glycosylation; LUSC cis rs7247513 0.964 rs8105902 chr19:12718351 G/A cg01871581 chr19:12707946 ZNF490 -0.54 -8.33 -0.41 2.16e-15 Bipolar disorder; LUSC trans rs9467711 0.659 rs34246779 chr6:26549212 G/A cg06606381 chr12:133084897 FBRSL1 -0.75 -6.68 -0.34 1.03e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs4234798 0.500 rs34694340 chr4:7221424 A/C cg18431297 chr4:7219810 SORCS2 0.34 6.41 0.33 4.9e-10 Insulin-like growth factors; LUSC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg17330251 chr7:94953956 PON1 -0.37 -5.99 -0.31 5.57e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2710642 0.962 rs2058567 chr2:63091426 T/C cg17519650 chr2:63277830 OTX1 0.47 6.41 0.33 4.83e-10 LDL cholesterol levels;LDL cholesterol; LUSC cis rs2072499 0.833 rs2758605 chr1:156200445 G/C cg25208724 chr1:156163844 SLC25A44 1.05 21.75 0.77 6.06e-66 Testicular germ cell tumor; LUSC cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg27446573 chr6:127587934 RNF146 -0.6 -9.05 -0.44 1.18e-17 Breast cancer; LUSC cis rs2295359 1.000 rs11465754 chr1:67631431 A/G cg12940439 chr1:67600707 NA 0.36 6.26 0.32 1.16e-9 Psoriasis; LUSC cis rs1577917 0.771 rs4383777 chr6:86435960 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.51 8.03 0.4 1.64e-14 Response to antipsychotic treatment; LUSC trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg11887960 chr12:57824829 NA 0.55 7.24 0.37 3.18e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg24642439 chr20:33292090 TP53INP2 0.74 12.06 0.55 4.93e-28 Coronary artery disease; LUSC trans rs4942242 1.000 rs7331003 chr13:44230253 C/T cg19169023 chr15:41853346 TYRO3 -0.5 -8.14 -0.41 8.16e-15 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg06784218 chr1:46089804 CCDC17 -0.53 -9.91 -0.48 1.8899999999999998e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9905704 0.671 rs2531736 chr17:56552204 A/G cg19466818 chr17:56409534 MIR142 0.36 6.61 0.34 1.53e-10 Testicular germ cell tumor; LUSC cis rs727505 0.721 rs11534064 chr7:124767997 G/T cg23710748 chr7:124431027 NA 0.38 6.93 0.35 2.15e-11 Lewy body disease; LUSC cis rs1335645 0.570 rs2165145 chr1:111625213 C/T cg00321911 chr1:111669324 DRAM2 -0.58 -6.23 -0.32 1.38e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7939886 0.920 rs11231821 chr11:55777052 C/G cg15704280 chr7:45808275 SEPT13 0.85 7.39 0.37 1.21e-12 Myopia (pathological); LUSC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg06634786 chr22:41940651 POLR3H 0.49 5.73 0.3 2.21e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg17971929 chr21:40555470 PSMG1 0.78 13.94 0.61 4.02e-35 Cognitive function; LUSC cis rs8062405 1.000 rs8055982 chr16:28881202 A/C cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2274273 0.712 rs17832311 chr14:55534466 A/G cg04306507 chr14:55594613 LGALS3 0.5 10.74 0.51 2.52e-23 Protein biomarker; LUSC cis rs6977660 0.714 rs13225018 chr7:19816567 C/T cg07541023 chr7:19748670 TWISTNB 0.63 6.74 0.35 7.05e-11 Thyroid stimulating hormone; LUSC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg13072238 chr3:49761600 GMPPB -0.36 -5.75 -0.3 2.02e-8 Body mass index; LUSC cis rs1372520 0.873 rs2583990 chr4:90771499 A/G cg01966878 chr4:90757139 SNCA -0.4 -5.67 -0.3 3.07e-8 Neuroticism; LUSC cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg04362960 chr10:104952993 NT5C2 0.62 9.73 0.47 7.36e-20 Arsenic metabolism; LUSC cis rs7760949 0.888 rs6939712 chr6:13897246 T/C cg27413430 chr6:13925136 RNF182 0.5 7.43 0.38 9.34e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg12751644 chr20:60527061 NA -0.35 -6.44 -0.33 4.23e-10 Body mass index; LUSC cis rs9534288 0.830 rs2404963 chr13:46632836 C/T cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC trans rs6600671 0.899 rs6674392 chr1:121260662 C/G cg00646200 chr1:148855367 NA 0.49 7.82 0.39 6.85e-14 Hip geometry; LUSC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg07701084 chr6:150067640 NUP43 0.57 8.76 0.43 9.76e-17 Lung cancer; LUSC cis rs11098499 0.691 rs28396837 chr4:120271541 G/A cg09307838 chr4:120376055 NA 0.63 9.59 0.46 2.07e-19 Corneal astigmatism; LUSC cis rs6500395 1.000 rs7188741 chr16:48607966 T/C cg04672837 chr16:48644449 N4BP1 0.46 6.89 0.35 2.76e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs12291225 0.637 rs8570 chr11:14300759 C/G cg05501817 chr11:14380813 RRAS2 -0.56 -8.87 -0.44 4.61e-17 Sense of smell; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg04576048 chr1:205797593 PM20D1 0.34 6.21 0.32 1.59e-9 Menarche (age at onset); LUSC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs17828380 0.925 rs12901035 chr15:63541446 A/C cg05507819 chr15:63340323 TPM1 -0.69 -5.87 -0.31 1.05e-8 Social communication problems; LUSC cis rs2730245 0.959 rs2527201 chr7:158738611 G/T cg14689365 chr7:158441557 NCAPG2 -0.45 -6.13 -0.32 2.46e-9 Height; LUSC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs1577917 0.559 rs1173418 chr6:86402916 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 7.2 0.37 4.13e-12 Response to antipsychotic treatment; LUSC cis rs3741151 0.686 rs7941359 chr11:73158119 A/G cg17517138 chr11:73019481 ARHGEF17 0.81 7.25 0.37 2.87e-12 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg26752003 chr8:145688521 CYHR1 0.55 9.26 0.45 2.52e-18 Age at first birth; LUSC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg15445000 chr17:37608096 MED1 -0.39 -6.8 -0.35 4.94e-11 Glomerular filtration rate (creatinine); LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg02951883 chr7:2050386 MAD1L1 -0.46 -8.08 -0.4 1.2e-14 Bipolar disorder and schizophrenia; LUSC cis rs2797160 1.000 rs61299898 chr6:126007651 G/C cg05901451 chr6:126070800 HEY2 0.58 8.59 0.43 3.43e-16 Endometrial cancer; LUSC cis rs6964587 0.967 rs12535601 chr7:91718346 A/G cg22709100 chr7:91322751 NA 0.4 5.85 0.3 1.17e-8 Breast cancer; LUSC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg17252645 chr8:143867129 LY6D 0.37 6.05 0.31 3.87e-9 Urinary tract infection frequency; LUSC cis rs9902453 0.845 rs3102556 chr17:28042542 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.39 0.46 9.91e-19 Coffee consumption (cups per day); LUSC cis rs9388451 0.839 rs4897157 chr6:126102981 A/T cg05901451 chr6:126070800 HEY2 -0.95 -18.47 -0.71 5.31e-53 Brugada syndrome; LUSC cis rs7618501 1.000 rs7648987 chr3:49868455 A/G cg13072238 chr3:49761600 GMPPB 0.43 7.15 0.36 5.45e-12 Intelligence (multi-trait analysis); LUSC cis rs10865397 0.506 rs13414160 chr2:73383261 C/A cg24220031 chr2:73402428 NA -0.27 -6.28 -0.33 1.03e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg25036284 chr2:26402008 FAM59B -0.7 -9.68 -0.47 1.04e-19 Gut microbiome composition (summer); LUSC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg11764359 chr7:65958608 NA 0.71 10.69 0.5 3.95e-23 Aortic root size; LUSC cis rs950169 0.686 rs12906474 chr15:85109237 A/G cg17173187 chr15:85201210 NMB 0.36 6.59 0.34 1.72e-10 Schizophrenia; LUSC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg09359103 chr1:154839909 KCNN3 -0.7 -16.24 -0.66 4.09e-44 Prostate cancer; LUSC cis rs68170813 0.652 rs116894096 chr7:107178477 G/A cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs11048434 0.736 rs7302417 chr12:9091116 G/T cg13575925 chr12:9217583 LOC144571 0.33 6.09 0.32 3.06e-9 Sjögren's syndrome; LUSC cis rs11971779 0.793 rs11772447 chr7:139033589 T/G cg07862535 chr7:139043722 LUC7L2 0.59 7.11 0.36 6.97e-12 Diisocyanate-induced asthma; LUSC cis rs2404602 0.622 rs9635380 chr15:77103479 A/G cg23625390 chr15:77176239 SCAPER -0.63 -9.23 -0.45 3.1e-18 Blood metabolite levels; LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg00166722 chr3:10149974 C3orf24 0.61 8.28 0.41 2.95e-15 Alzheimer's disease; LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.62 -0.38 2.69e-13 Lymphocyte counts; LUSC cis rs11809207 0.723 rs57653638 chr1:26524401 A/G cg00147160 chr1:26503991 CNKSR1 0.42 6.86 0.35 3.26e-11 Height; LUSC trans rs11039798 0.588 rs3924476 chr11:48581733 T/C cg15704280 chr7:45808275 SEPT13 0.63 7.17 0.37 5e-12 Axial length; LUSC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.88 0.48 2.29e-20 Personality dimensions; LUSC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.33 5.75 0.3 1.97e-8 Total body bone mineral density; LUSC cis rs3126085 0.935 rs12409762 chr1:152175398 G/A cg03465714 chr1:152285911 FLG 0.41 5.81 0.3 1.43e-8 Atopic dermatitis; LUSC trans rs7819412 1.000 rs7819412 chr8:11045161 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.08 0.4 1.2e-14 Triglycerides; LUSC cis rs2046867 0.818 rs62249860 chr3:72866073 T/G cg25664220 chr3:72788482 NA -0.7 -11.88 -0.54 2.26e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10484885 0.824 rs72919976 chr6:90526686 C/G cg13799429 chr6:90582589 CASP8AP2 -0.85 -7.94 -0.4 3.01e-14 QRS interval (sulfonylurea treatment interaction); LUSC cis rs240764 0.817 rs11155596 chr6:101152631 C/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.04 -0.31 4.09e-9 Neuroticism; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg00024416 chr22:24240387 NA -0.31 -5.71 -0.3 2.53e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg10755058 chr3:40428713 ENTPD3 0.35 5.89 0.31 9.27e-9 Renal cell carcinoma; LUSC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2073300 1.000 rs6036423 chr20:23459810 A/C cg09953122 chr20:23471693 CST8 -0.69 -6.84 -0.35 3.84e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs909674 0.690 rs5750823 chr22:39829973 C/T cg02038168 chr22:39784481 NA -0.46 -6.89 -0.35 2.77e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9583531 0.891 rs61969076 chr13:111391568 C/T cg24331049 chr13:111365604 ING1 -0.63 -6.75 -0.35 6.53e-11 Coronary artery disease; LUSC cis rs11785400 1.000 rs4557682 chr8:143738182 T/C cg10596483 chr8:143751796 JRK 0.61 9.41 0.46 8.19e-19 Schizophrenia; LUSC trans rs4843747 0.749 rs72818535 chr16:88074039 G/A cg26811252 chr16:29126840 RRN3P2 0.64 10.32 0.49 7.6e-22 Menopause (age at onset); LUSC cis rs73001065 0.901 rs73004933 chr19:19675696 C/T cg03709012 chr19:19516395 GATAD2A 0.88 6.92 0.35 2.27e-11 LDL cholesterol; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg23682940 chr15:101419483 ALDH1A3 -0.54 -6.46 -0.33 3.7e-10 Bipolar disorder and schizophrenia; LUSC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg25838465 chr1:92012736 NA -0.74 -15.16 -0.64 7.24e-40 Breast cancer; LUSC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg03289416 chr15:75166202 SCAMP2 0.45 6.87 0.35 3.13e-11 Breast cancer; LUSC cis rs1160297 0.576 rs12990843 chr2:53108688 A/G cg07782112 chr2:53107842 NA 0.43 7.26 0.37 2.66e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs11828289 0.660 rs28825707 chr11:23224075 G/A cg20040320 chr11:23191996 NA -0.61 -6.3 -0.33 9.26e-10 Cancer; LUSC cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg00129232 chr17:37814104 STARD3 -0.5 -7.4 -0.38 1.09e-12 Asthma; LUSC cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg06784218 chr1:46089804 CCDC17 0.55 11.51 0.53 4.8e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.14 -0.36 5.91e-12 Intelligence (multi-trait analysis); LUSC cis rs7523050 0.908 rs12404382 chr1:109397129 G/A cg08274380 chr1:109419600 GPSM2 0.87 9.52 0.46 3.5e-19 Fat distribution (HIV); LUSC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg06008330 chr7:65541103 ASL -0.4 -6.37 -0.33 6.37e-10 Aortic root size; LUSC cis rs1577917 0.958 rs34622605 chr6:86456519 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -7.07 -0.36 9.36e-12 Response to antipsychotic treatment; LUSC cis rs3087591 0.879 rs59015798 chr17:29580882 G/A cg24425628 chr17:29625626 OMG;NF1 -0.63 -9.05 -0.44 1.2e-17 Hip circumference; LUSC cis rs1568889 0.838 rs7943538 chr11:28288955 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 13.07 0.58 8.1e-32 Bipolar disorder; LUSC cis rs9527 0.615 rs10883804 chr10:104706520 G/A cg23093090 chr10:104574429 C10orf26 -0.36 -6.68 -0.34 1e-10 Arsenic metabolism; LUSC cis rs2991971 1.000 rs2993262 chr1:46013733 G/C cg24296786 chr1:45957014 TESK2 0.48 7.01 0.36 1.29e-11 High light scatter reticulocyte count; LUSC cis rs10492096 0.783 rs11064220 chr12:6592574 C/T cg13857086 chr12:6580257 VAMP1 0.58 6.76 0.35 6.09e-11 Hip geometry; LUSC cis rs17253792 0.822 rs75232282 chr14:56067290 G/C cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs9487051 0.735 rs459956 chr6:109524760 A/G cg01475377 chr6:109611718 NA -0.35 -5.89 -0.31 9.36e-9 Reticulocyte fraction of red cells; LUSC cis rs4604732 0.631 rs35046441 chr1:247626812 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs9291683 0.609 rs4622999 chr4:10003395 C/G cg26043149 chr18:55253948 FECH 0.48 6.97 0.36 1.69e-11 Bone mineral density; LUSC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg04546413 chr19:29218101 NA 0.72 11.5 0.53 5.38e-26 Methadone dose in opioid dependence; LUSC trans rs9291683 0.588 rs4280729 chr4:10013861 C/T cg26043149 chr18:55253948 FECH 0.51 7.66 0.39 2.01e-13 Bone mineral density; LUSC cis rs17255340 0.520 rs1170498 chr6:83987602 T/C cg08257003 chr6:84140564 ME1 0.33 8.18 0.41 6.19e-15 Platelet-derived growth factor BB levels; LUSC trans rs1908814 0.516 rs56102998 chr8:11796675 G/A cg08975724 chr8:8085496 FLJ10661 0.47 6.66 0.34 1.16e-10 Neuroticism; LUSC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg09034736 chr1:150693464 HORMAD1 0.49 7.17 0.37 4.82e-12 Tonsillectomy; LUSC cis rs9925964 0.967 rs12716981 chr16:31118024 C/A cg03418659 chr16:31128414 MYST1 0.4 6.36 0.33 6.62e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2235642 0.891 rs2281231 chr16:1601879 A/G cg26528668 chr16:1614120 IFT140 0.48 8.21 0.41 4.79e-15 Coronary artery disease; LUSC cis rs3740713 1.000 rs35593189 chr11:18468378 C/T cg23797887 chr11:18477753 LDHAL6A -0.59 -7.14 -0.36 5.93e-12 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs10506458 0.834 rs12426860 chr12:63387948 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.16 -14.73 -0.63 3.53e-38 Hemostatic factors and hematological phenotypes; LUSC cis rs3815700 1.000 rs8104729 chr19:33093979 C/T cg02997394 chr19:33096574 ANKRD27 0.79 8.95 0.44 2.44e-17 Eosinophilic esophagitis; LUSC cis rs7166081 0.704 rs2414952 chr15:67724392 A/T cg24579218 chr15:68104479 NA -0.37 -6.25 -0.32 1.26e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs7572644 0.699 rs12465000 chr2:28199424 G/A cg27432699 chr2:27873401 GPN1 -0.51 -6.9 -0.35 2.65e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs2667011 0.512 rs3792161 chr2:160809223 C/T cg06573604 chr2:160760825 LY75 0.45 6.28 0.32 1.07e-9 Bilirubin levels; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.8 0.3 1.5e-8 Menopause (age at onset); LUSC cis rs7582180 0.903 rs2309821 chr2:100900304 A/G cg08017756 chr2:100939284 LONRF2 -0.36 -6.11 -0.32 2.83e-9 Intelligence (multi-trait analysis); LUSC cis rs2235649 0.833 rs55684627 chr16:1848817 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.03 -0.31 4.44e-9 Blood metabolite levels; LUSC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.92 -13.21 -0.59 2.33e-32 Chronic sinus infection; LUSC cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg23711669 chr6:146136114 FBXO30 0.75 13.38 0.59 5.42e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg12573674 chr2:1569213 NA -0.57 -8.08 -0.4 1.18e-14 IgG glycosylation; LUSC cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -11.15 -0.52 9.49e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22455342 chr2:225449267 CUL3 0.76 10.26 0.49 1.19e-21 IgE levels in asthmatics (D.p. specific); LUSC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg09824328 chr1:43425412 SLC2A1 -0.45 -5.67 -0.3 3.06e-8 Monocyte count; LUSC cis rs6545883 0.929 rs6705235 chr2:61713580 G/C cg15711740 chr2:61764176 XPO1 -0.45 -6.84 -0.35 3.85e-11 Tuberculosis; LUSC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg04733989 chr22:42467013 NAGA 0.55 8.57 0.42 3.78e-16 Schizophrenia; LUSC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg02475777 chr4:1388615 CRIPAK 0.38 5.65 0.3 3.37e-8 Obesity-related traits; LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.52 0.59 1.57e-33 Platelet count; LUSC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg21963583 chr11:68658836 MRPL21 0.56 8.33 0.41 2.15e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs72772090 0.539 rs10515249 chr5:96125259 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.96 -0.36 1.82e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs2980439 0.846 rs2980437 chr8:8094763 C/T cg21775007 chr8:11205619 TDH -0.44 -6.26 -0.32 1.17e-9 Neuroticism; LUSC cis rs7605378 0.658 rs4673507 chr2:200710167 G/C cg23649088 chr2:200775458 C2orf69 0.67 10.77 0.51 2.06e-23 Osteoporosis; LUSC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg16647868 chr5:131706066 SLC22A5 -0.38 -5.73 -0.3 2.29e-8 Blood metabolite levels; LUSC cis rs12620999 0.555 rs10199274 chr2:238111864 G/C cg23555395 chr2:238036564 NA -0.31 -5.8 -0.3 1.53e-8 Systemic lupus erythematosus; LUSC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC cis rs939574 0.790 rs2385397 chr2:220087796 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.8 -5.93 -0.31 7.69e-9 Platelet distribution width; LUSC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg26408565 chr15:76604113 ETFA -0.5 -8.04 -0.4 1.61e-14 Blood metabolite levels; LUSC cis rs3857536 0.776 rs7765531 chr6:66932886 G/A cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs61931739 0.517 rs11052964 chr12:34010996 G/C cg06521331 chr12:34319734 NA -0.47 -7.52 -0.38 5.03e-13 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2952156 0.959 rs2941503 chr17:37828745 A/G cg20243544 chr17:37824526 PNMT 0.52 7.53 0.38 4.88e-13 Asthma; LUSC cis rs34779708 0.733 rs12243593 chr10:35549045 C/T cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg18099408 chr3:52552593 STAB1 0.35 6.0 0.31 5.23e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs4423214 0.592 rs10898211 chr11:71210677 T/C cg05163923 chr11:71159392 DHCR7 -0.68 -7.16 -0.36 5.29e-12 Vitamin D levels; LUSC cis rs2274273 1.000 rs15870 chr14:55619311 A/G cg04306507 chr14:55594613 LGALS3 0.54 11.95 0.55 1.23e-27 Protein biomarker; LUSC trans rs9929218 0.551 rs2274240 chr16:68725486 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.1 26.19 0.82 5.97e-83 Colorectal cancer; LUSC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg13206674 chr6:150067644 NUP43 0.49 7.02 0.36 1.21e-11 Lung cancer; LUSC cis rs11166629 1.000 rs11166629 chr8:135636964 C/T cg27224718 chr8:135614730 ZFAT 0.66 11.2 0.52 5.95e-25 Smoking quantity; LUSC cis rs1577917 1.000 rs1857964 chr6:86635994 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.76 -0.43 9.87e-17 Response to antipsychotic treatment; LUSC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg08392591 chr16:89556376 ANKRD11 0.39 5.82 0.3 1.36e-8 Multiple myeloma (IgH translocation); LUSC trans rs12310956 0.532 rs1525904 chr12:33962448 T/C cg13010199 chr12:38710504 ALG10B 0.57 8.51 0.42 6.15e-16 Morning vs. evening chronotype; LUSC cis rs10751667 0.666 rs10794354 chr11:954615 A/T ch.11.42038R chr11:967971 AP2A2 0.43 6.49 0.33 3.07e-10 Alzheimer's disease (late onset); LUSC cis rs9888739 1.000 rs9940397 chr16:31303201 T/C cg15817542 chr16:31343056 ITGAM -0.51 -6.06 -0.31 3.69e-9 Systemic lupus erythematosus; LUSC cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg09469691 chr10:81107165 PPIF 0.69 10.46 0.5 2.42e-22 Height; LUSC cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg20503657 chr10:835505 NA -0.67 -10.62 -0.5 6.87e-23 Eosinophil percentage of granulocytes; LUSC cis rs546131 0.928 rs552171 chr11:34830709 G/T cg11058730 chr11:34937778 PDHX;APIP 0.47 6.31 0.33 8.91e-10 Lung disease severity in cystic fibrosis; LUSC cis rs478304 0.530 rs11568300 chr11:65425167 C/G cg27068330 chr11:65405492 SIPA1 -0.75 -10.5 -0.5 1.75e-22 Acne (severe); LUSC cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg15839431 chr19:19639596 YJEFN3 -0.64 -7.21 -0.37 3.65e-12 Bipolar disorder; LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg19318889 chr4:1322082 MAEA 0.49 8.11 0.41 9.51e-15 Longevity; LUSC cis rs13253111 0.624 rs4732844 chr8:28104473 A/G cg26534493 chr8:28060551 NA -0.39 -7.07 -0.36 9.26e-12 Childhood body mass index; LUSC cis rs11166629 1.000 rs2873014 chr8:135645860 C/T cg27224718 chr8:135614730 ZFAT -0.63 -10.23 -0.49 1.52e-21 Smoking quantity; LUSC cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg06238570 chr21:40685208 BRWD1 -0.56 -8.74 -0.43 1.16e-16 Menarche (age at onset); LUSC cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg08798685 chr6:27730294 NA -0.64 -6.01 -0.31 4.93e-9 Breast cancer; LUSC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.49 8.35 0.42 1.88e-15 Menopause (age at onset); LUSC cis rs34779708 0.931 rs17583009 chr10:35320915 T/C cg03585969 chr10:35415529 CREM 0.6 8.67 0.43 1.86e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg06022373 chr22:39101656 GTPBP1 0.78 12.08 0.55 3.89e-28 Menopause (age at onset); LUSC cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg24450063 chr1:156163899 SLC25A44 1.18 29.35 0.85 1.67e-94 Testicular germ cell tumor; LUSC cis rs2692947 0.702 rs4907291 chr2:96654605 T/G cg22654517 chr2:96458247 NA 0.33 6.75 0.35 6.52e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs8060686 0.516 rs11075670 chr16:68288393 C/G cg09835421 chr16:68378352 PRMT7 -0.51 -6.24 -0.32 1.33e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg24642439 chr20:33292090 TP53INP2 -0.49 -7.39 -0.38 1.15e-12 Glomerular filtration rate (creatinine); LUSC cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg23788917 chr6:8435910 SLC35B3 0.5 7.38 0.37 1.23e-12 Motion sickness; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg16405210 chr4:1374714 KIAA1530 -0.58 -9.51 -0.46 3.76e-19 Longevity; LUSC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.77 -11.02 -0.52 2.8e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6977660 0.619 rs2158379 chr7:19783977 A/G cg05791153 chr7:19748676 TWISTNB 0.67 6.98 0.36 1.63e-11 Thyroid stimulating hormone; LUSC cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg08213375 chr14:104286397 PPP1R13B 0.51 10.05 0.48 6.22e-21 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03115081 chr17:74722049 C17orf95;JMJD6 0.48 7.0 0.36 1.4e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs911555 0.504 rs61995761 chr14:104075712 T/C cg12935359 chr14:103987150 CKB -0.5 -7.75 -0.39 1.1e-13 Intelligence (multi-trait analysis); LUSC cis rs4604732 0.631 rs7546720 chr1:247627229 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg08273200 chr1:39338480 MYCBP -0.44 -6.11 -0.32 2.75e-9 Hepatitis; LUSC cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg23788917 chr6:8435910 SLC35B3 0.5 7.49 0.38 6.07e-13 Motion sickness; LUSC cis rs2692947 0.550 rs4613327 chr2:96583823 G/A cg23100626 chr2:96804247 ASTL 0.32 7.43 0.38 9.38e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1153858 0.945 rs2467854 chr15:45701597 A/G cg21132104 chr15:45694354 SPATA5L1 0.56 7.77 0.39 1.01e-13 Homoarginine levels; LUSC cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg11266682 chr4:10021025 SLC2A9 0.53 9.36 0.46 1.16e-18 Bone mineral density; LUSC cis rs6121246 0.697 rs6060446 chr20:30231637 T/C cg21427119 chr20:30132790 HM13 -0.42 -6.33 -0.33 7.85e-10 Mean corpuscular hemoglobin; LUSC cis rs870825 0.860 rs72703521 chr4:185603080 T/C cg04058563 chr4:185651563 MLF1IP 0.77 10.26 0.49 1.17e-21 Blood protein levels; LUSC cis rs7249142 0.549 rs539 chr19:19287802 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 9.5 0.46 4.33e-19 IgG glycosylation; LUSC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg13628971 chr7:2884303 GNA12 -0.49 -7.13 -0.36 6.05e-12 Height; LUSC cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.74 8.67 0.43 1.88e-16 Schizophrenia; LUSC cis rs11030122 0.673 rs4910869 chr11:4006438 C/T cg08557956 chr11:4115526 RRM1 -0.45 -5.74 -0.3 2.18e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg03354898 chr7:1950403 MAD1L1 -0.47 -9.64 -0.47 1.46e-19 Bipolar disorder and schizophrenia; LUSC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg00074818 chr8:8560427 CLDN23 0.58 9.87 0.48 2.57e-20 Obesity-related traits; LUSC cis rs9322193 0.887 rs4870139 chr6:149896318 T/C cg13206674 chr6:150067644 NUP43 0.58 8.9 0.44 3.55e-17 Lung cancer; LUSC cis rs12681288 0.723 rs35425201 chr8:971062 C/T cg15309053 chr8:964076 NA 0.36 7.24 0.37 3.19e-12 Schizophrenia; LUSC cis rs1008375 0.933 rs4698637 chr4:17632843 A/T cg04450456 chr4:17643702 FAM184B 0.39 6.5 0.34 2.87e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2742417 0.587 rs2742375 chr3:45784602 G/A cg10512202 chr3:45649293 LIMD1 0.37 6.11 0.32 2.76e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs240764 0.681 rs12209887 chr6:101156806 G/A cg09795085 chr6:101329169 ASCC3 -0.42 -6.08 -0.32 3.3e-9 Neuroticism; LUSC cis rs354225 0.544 rs3796018 chr2:54807281 C/T cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg04455712 chr21:45112962 RRP1B 0.47 9.01 0.44 1.6e-17 Mean corpuscular volume; LUSC cis rs6005807 0.719 rs9625521 chr22:29039953 T/G cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg07424592 chr7:64974309 NA 0.66 5.83 0.3 1.32e-8 Diabetic kidney disease; LUSC cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg06212747 chr3:49208901 KLHDC8B 0.44 6.1 0.32 2.92e-9 Parkinson's disease; LUSC cis rs11645898 0.748 rs72787056 chr16:72099694 C/T cg14768367 chr16:72042858 DHODH -0.69 -7.5 -0.38 5.95e-13 Blood protein levels; LUSC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg11752832 chr7:134001865 SLC35B4 0.54 8.17 0.41 6.31e-15 Mean platelet volume; LUSC cis rs1692580 0.682 rs12045693 chr1:2205581 A/C cg24578937 chr1:2090814 PRKCZ -0.3 -6.31 -0.33 8.66e-10 Coronary artery disease; LUSC cis rs7786877 0.582 rs2075674 chr7:100225031 G/A cg16850897 chr7:100343110 ZAN -0.5 -6.12 -0.32 2.55e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg05855489 chr10:104503620 C10orf26 0.66 10.21 0.49 1.8e-21 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg21361702 chr7:150065534 REPIN1 0.49 6.78 0.35 5.31e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg09491104 chr22:46646882 C22orf40 -0.67 -7.08 -0.36 8.7e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg20887711 chr4:1340912 KIAA1530 0.56 8.85 0.44 5.14e-17 Longevity; LUSC cis rs7043114 0.525 rs7047089 chr9:95117980 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.61 -0.34 1.51e-10 Height; LUSC cis rs950169 0.580 rs1061737 chr15:85183790 G/C cg17507749 chr15:85114479 UBE2QP1 0.57 7.32 0.37 1.88e-12 Schizophrenia; LUSC cis rs9400467 0.509 rs11153287 chr6:111704537 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.34 -6.19 -0.32 1.75e-9 Blood metabolite levels;Amino acid levels; LUSC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg22907277 chr7:1156413 C7orf50 0.7 10.3 0.49 8.95e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg00172270 chr12:50101356 FMNL3 -0.42 -6.3 -0.33 9.53e-10 Electrocardiographic conduction measures; LUSC cis rs61990749 0.597 rs8003691 chr14:78211225 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.59 6.44 0.33 4.27e-10 Fibroblast growth factor basic levels; LUSC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg26879891 chr1:152191343 HRNR -0.38 -6.77 -0.35 5.93e-11 Inflammatory skin disease; LUSC cis rs7829975 0.782 rs6990746 chr8:8547811 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.11 -0.32 2.73e-9 Mood instability; LUSC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg20203395 chr5:56204925 C5orf35 -0.75 -10.33 -0.49 6.65e-22 Initial pursuit acceleration; LUSC cis rs17095355 1.000 rs731793 chr10:111716667 C/G cg00817464 chr10:111662876 XPNPEP1 0.58 7.31 0.37 2.03e-12 Biliary atresia; LUSC cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -8.17 -0.41 6.4e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7953249 0.594 rs11065384 chr12:121423285 T/C cg02403541 chr12:121454288 C12orf43 -0.71 -10.82 -0.51 1.4e-23 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; LUSC cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg27446573 chr6:127587934 RNF146 0.92 15.38 0.64 1.02e-40 Breast cancer; LUSC cis rs11112613 0.713 rs60865625 chr12:105940256 A/C cg03607813 chr12:105948248 NA 0.78 11.99 0.55 8.75e-28 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03090513 chr2:208394450 CREB1 -0.46 -7.0 -0.36 1.4e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs981844 0.712 rs4469056 chr4:154745796 A/T cg14289246 chr4:154710475 SFRP2 0.46 6.25 0.32 1.24e-9 Response to statins (LDL cholesterol change); LUSC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg00339695 chr16:24857497 SLC5A11 -0.62 -9.69 -0.47 1e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7617480 0.549 rs9879978 chr3:48846600 T/G cg07636037 chr3:49044803 WDR6 0.9 12.07 0.55 4.33e-28 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7746199 0.736 rs17749927 chr6:27669976 A/G cg26958806 chr6:27640298 NA 0.75 6.01 0.31 4.76e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg18190219 chr22:46762943 CELSR1 -0.54 -6.02 -0.31 4.61e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs614226 0.938 rs7963543 chr12:120923948 C/A cg01236616 chr12:121019343 POP5 1.28 21.0 0.75 5.36e-63 Type 1 diabetes nephropathy; LUSC trans rs35110281 0.714 rs7277539 chr21:45053011 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 12.09 0.55 3.62e-28 Mean corpuscular volume; LUSC cis rs34779708 1.000 rs12769189 chr10:35399668 A/G cg03585969 chr10:35415529 CREM 0.62 8.97 0.44 2.2e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7903847 0.642 rs11189178 chr10:99143272 T/G cg08345082 chr10:99160200 RRP12 -0.36 -7.3 -0.37 2.19e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs60154123 0.730 rs11119455 chr1:210457762 C/T cg22029157 chr1:209979665 IRF6 0.52 5.88 0.31 9.74e-9 Coronary artery disease; LUSC cis rs4906332 1.000 rs17617094 chr14:103893428 T/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.46e-12 Coronary artery disease; LUSC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.84 0.44 5.53e-17 Schizophrenia; LUSC cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.47 0.38 6.96e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg26647111 chr11:31128758 NA -0.42 -6.03 -0.31 4.44e-9 Red blood cell count; LUSC cis rs7098414 0.531 rs3844126 chr10:82019997 T/G cg00277334 chr10:82204260 NA -0.37 -5.74 -0.3 2.08e-8 Post bronchodilator FEV1; LUSC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg00033643 chr7:134001901 SLC35B4 0.46 7.19 0.37 4.19e-12 Mean platelet volume; LUSC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg11494091 chr17:61959527 GH2 0.39 6.75 0.35 6.74e-11 Height; LUSC cis rs11605924 0.819 rs12805422 chr11:45839889 G/A ch.11.939596F chr11:45881766 CRY2 -0.51 -7.54 -0.38 4.42e-13 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.42 6.06 0.31 3.77e-9 Systemic lupus erythematosus; LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg16647868 chr5:131706066 SLC22A5 0.4 6.31 0.33 9.09e-10 Breast cancer; LUSC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg08219700 chr8:58056026 NA 0.64 7.88 0.4 4.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.720 rs1338179 chr1:152981548 T/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.58 -0.38 3.48e-13 Inflammatory skin disease; LUSC cis rs2299587 0.650 rs12548412 chr8:17796970 G/T cg01800426 chr8:17659068 MTUS1 -0.49 -6.53 -0.34 2.44e-10 Economic and political preferences; LUSC cis rs62400317 0.821 rs34455867 chr6:45172071 T/C cg20913747 chr6:44695427 NA -0.47 -7.58 -0.38 3.5e-13 Total body bone mineral density; LUSC cis rs8028313 0.731 rs11857017 chr15:67972908 A/G cg27219399 chr15:67835830 MAP2K5 0.35 5.7 0.3 2.63e-8 Obesity; LUSC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg00149659 chr3:10157352 C3orf10 0.95 12.55 0.57 7.6e-30 Alzheimer's disease; LUSC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg13395646 chr4:1353034 KIAA1530 0.5 7.26 0.37 2.77e-12 Obesity-related traits; LUSC cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.81 0.39 7.71e-14 Colorectal cancer; LUSC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg22166914 chr1:53195759 ZYG11B -0.7 -12.09 -0.55 3.61e-28 Monocyte count; LUSC cis rs4727027 0.704 rs12535115 chr7:148895087 C/T cg23158103 chr7:148848205 ZNF398 -0.5 -8.4 -0.42 1.33e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs734999 0.545 rs4648565 chr1:2570023 A/G cg18932078 chr1:2524107 MMEL1 -0.3 -6.41 -0.33 4.96e-10 Ulcerative colitis; LUSC cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg16447950 chr5:562315 NA -0.48 -6.62 -0.34 1.47e-10 Obesity-related traits; LUSC cis rs9527 0.640 rs35195396 chr10:104928770 T/A cg04362960 chr10:104952993 NT5C2 0.61 9.53 0.46 3.35e-19 Arsenic metabolism; LUSC cis rs4642101 0.512 rs9813960 chr3:12818205 A/G cg24848339 chr3:12840334 CAND2 0.35 7.9 0.4 4.04e-14 QRS complex (12-leadsum); LUSC cis rs7954584 0.567 rs11043233 chr12:122330733 C/T cg21171335 chr12:122356390 WDR66 0.64 9.77 0.47 5.35e-20 Mean corpuscular volume; LUSC cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.56e-13 Motion sickness; LUSC cis rs10779751 0.734 rs2261217 chr1:11127764 C/A cg08854313 chr1:11322531 MTOR 0.81 12.1 0.55 3.52e-28 Body mass index; LUSC cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg20302533 chr7:39170763 POU6F2 0.5 7.88 0.4 4.72e-14 IgG glycosylation; LUSC cis rs1580019 0.961 rs4255041 chr7:32496383 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.78 11.81 0.54 3.97e-27 Cognitive ability; LUSC cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg13010199 chr12:38710504 ALG10B 0.69 10.64 0.5 6.03e-23 Bladder cancer; LUSC cis rs34779708 0.897 rs7900480 chr10:35338699 A/G cg04310649 chr10:35416472 CREM 0.43 6.87 0.35 3.11e-11 Inflammatory bowel disease;Crohn's disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20264566 chr11:10316295 SBF2 -0.42 -6.14 -0.32 2.33e-9 Hepatitis; LUSC cis rs208520 0.634 rs3909071 chr6:66836947 T/C cg07460842 chr6:66804631 NA -1.15 -17.63 -0.69 1.21e-49 Exhaled nitric oxide output; LUSC cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg22709100 chr7:91322751 NA 0.39 5.8 0.3 1.56e-8 Breast cancer; LUSC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg11752832 chr7:134001865 SLC35B4 0.59 9.29 0.45 2.08e-18 Mean platelet volume; LUSC cis rs10464366 0.798 rs885352 chr7:39116168 A/G cg18850127 chr7:39170497 POU6F2 0.4 6.0 0.31 5.21e-9 IgG glycosylation; LUSC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs4423214 0.802 rs4616066 chr11:71183846 G/A cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs11969893 0.649 rs1321204 chr6:101468591 A/G cg12253828 chr6:101329408 ASCC3 0.89 7.28 0.37 2.48e-12 Economic and political preferences (immigration/crime); LUSC cis rs9868809 0.542 rs9873726 chr3:48712367 C/T cg00383909 chr3:49044727 WDR6 0.84 7.81 0.39 7.28e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC trans rs10802346 0.514 rs4443861 chr1:246372574 G/T cg22732515 chr19:44031385 ETHE1 0.63 10.24 0.49 1.42e-21 Fractional exhaled nitric oxide (childhood); LUSC cis rs2262909 0.925 rs56073035 chr19:22276298 C/G cg11619707 chr19:22235551 ZNF257 0.39 5.79 0.3 1.63e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13732083 chr21:47605072 C21orf56 -0.45 -6.6 -0.34 1.62e-10 Testicular germ cell tumor; LUSC trans rs61931739 0.817 rs1705771 chr12:34174950 C/G cg26384229 chr12:38710491 ALG10B 0.55 9.03 0.44 1.36e-17 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg22535103 chr8:58192502 C8orf71 0.61 6.95 0.36 1.95e-11 Developmental language disorder (linguistic errors); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg26534856 chr2:44223049 LRPPRC 0.39 6.16 0.32 2.07e-9 Metabolite levels (Pyroglutamine); LUSC cis rs7584330 0.554 rs10176035 chr2:238433449 T/C cg16989719 chr2:238392110 NA -0.39 -5.69 -0.3 2.79e-8 Prostate cancer; LUSC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg08470875 chr2:26401718 FAM59B -0.67 -8.99 -0.44 1.82e-17 Gut microbiome composition (summer); LUSC cis rs4555082 0.957 rs3825762 chr14:105752404 T/C cg06808227 chr14:105710500 BRF1 -0.65 -9.61 -0.47 1.89e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg13395646 chr4:1353034 KIAA1530 -0.51 -7.34 -0.37 1.59e-12 Obesity-related traits; LUSC cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC trans rs6600671 1.000 rs1591882 chr1:121183313 G/A cg00646200 chr1:148855367 NA 0.44 7.0 0.36 1.37e-11 Hip geometry; LUSC cis rs12477438 0.765 rs6722164 chr2:99561527 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.64e-15 Chronic sinus infection; LUSC cis rs9359856 0.564 rs1179902 chr6:90321545 C/T cg13799429 chr6:90582589 CASP8AP2 -0.81 -8.0 -0.4 2.09e-14 Bipolar disorder; LUSC cis rs73195822 0.667 rs7967386 chr12:111239162 G/A cg12870014 chr12:110450643 ANKRD13A 0.71 6.82 0.35 4.17e-11 Itch intensity from mosquito bite; LUSC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg06238570 chr21:40685208 BRWD1 0.49 7.37 0.37 1.37e-12 Cognitive function; LUSC cis rs240764 0.817 rs6905221 chr6:101151537 G/A cg09795085 chr6:101329169 ASCC3 -0.42 -6.17 -0.32 2.01e-9 Neuroticism; LUSC cis rs6500602 0.727 rs12443748 chr16:4541831 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.5 6.53 0.34 2.4e-10 Schizophrenia; LUSC cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg02753203 chr1:228287806 NA -0.65 -10.98 -0.52 3.73e-24 Diastolic blood pressure; LUSC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg23711669 chr6:146136114 FBXO30 -0.93 -17.89 -0.7 1.08e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.594 rs7308707 chr12:38450428 G/C cg13010199 chr12:38710504 ALG10B -0.44 -6.56 -0.34 1.99e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs1957429 0.520 rs230715 chr14:65320549 G/C cg23373153 chr14:65346875 NA -0.81 -7.45 -0.38 8.14e-13 Pediatric areal bone mineral density (radius); LUSC cis rs41271473 0.898 rs72750015 chr1:228811318 A/G cg16512390 chr1:228756714 NA 0.52 6.27 0.32 1.1e-9 Chronic lymphocytic leukemia; LUSC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg01579765 chr21:45077557 HSF2BP -0.53 -11.05 -0.52 2.07e-24 Mean corpuscular volume; LUSC cis rs67460515 0.892 rs6780536 chr3:161058726 T/C cg03342759 chr3:160939853 NMD3 -0.53 -7.59 -0.38 3.16e-13 Parkinson's disease; LUSC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11644478 chr21:40555479 PSMG1 -0.77 -13.67 -0.6 4.45e-34 Cognitive function; LUSC cis rs10504229 0.516 rs58244172 chr8:57987805 G/A cg22535103 chr8:58192502 C8orf71 -0.48 -6.46 -0.33 3.76e-10 Developmental language disorder (linguistic errors); LUSC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg06713675 chr4:122721982 EXOSC9 -0.43 -7.75 -0.39 1.09e-13 Type 2 diabetes; LUSC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg24531977 chr5:56204891 C5orf35 -0.7 -10.28 -0.49 1.01e-21 Coronary artery disease; LUSC trans rs7824557 0.564 rs13268126 chr8:11230574 G/A cg15556689 chr8:8085844 FLJ10661 -0.52 -7.85 -0.39 5.56e-14 Retinal vascular caliber; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg07507251 chr3:52567010 NT5DC2 0.36 6.26 0.32 1.2e-9 Bipolar disorder; LUSC cis rs10740039 0.810 rs1006956 chr10:62367976 A/G cg18175470 chr10:62150864 ANK3 0.43 6.5 0.33 3e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11098499 0.908 rs7696649 chr4:120322177 G/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg27494647 chr7:150038898 RARRES2 0.52 7.82 0.39 7.1e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs2760061 0.603 rs697762 chr1:228192410 G/A cg18477163 chr1:228402036 OBSCN 0.53 9.23 0.45 3.15e-18 Diastolic blood pressure; LUSC trans rs6977660 0.770 rs10224061 chr7:19852619 C/G cg15945262 chr7:1881887 MAD1L1 -0.45 -6.51 -0.34 2.84e-10 Thyroid stimulating hormone; LUSC cis rs1801251 0.778 rs809639 chr2:233731244 C/G cg25237894 chr2:233734115 C2orf82 0.35 6.71 0.34 8.48e-11 Coronary artery disease; LUSC trans rs6126344 0.957 rs6021437 chr20:50407162 T/C cg03643032 chr16:85954903 IRF8 0.3 5.97 0.31 6.16e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs7043114 0.525 rs7863406 chr9:95053381 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.44 -0.33 4.16e-10 Height; LUSC cis rs1413885 0.549 rs9436726 chr1:65853196 T/C cg14976592 chr1:65886160 LEPROT;LEPR 0.46 6.76 0.35 6.34e-11 Anticoagulant levels; LUSC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg04450456 chr4:17643702 FAM184B 0.43 7.21 0.37 3.8e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2688419 0.545 rs1849478 chr3:23067010 C/G cg00327796 chr3:23032191 NA -0.42 -7.36 -0.37 1.45e-12 Type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24110916 chr15:65282490 SPG21 0.36 6.18 0.32 1.84e-9 Triglycerides; LUSC cis rs1559088 0.649 rs4528686 chr19:33556074 A/G cg17764715 chr19:33622953 WDR88 0.59 7.95 0.4 2.96e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7100689 0.646 rs1340382 chr10:82096997 G/C cg00277334 chr10:82204260 NA -0.57 -8.67 -0.43 1.9e-16 Post bronchodilator FEV1; LUSC cis rs68170813 0.559 rs6965001 chr7:106933196 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.82 -0.47 3.55e-20 Coronary artery disease; LUSC cis rs6582630 0.502 rs11520261 chr12:38332019 T/G cg26384229 chr12:38710491 ALG10B 0.84 13.8 0.6 1.32e-34 Drug-induced liver injury (flucloxacillin); LUSC cis rs2692947 0.702 rs6717101 chr2:96505552 C/T cg23100626 chr2:96804247 ASTL 0.26 6.5 0.34 2.93e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11719291 0.504 rs71324924 chr3:48865444 G/A cg00383909 chr3:49044727 WDR6 1.27 11.48 0.53 5.96e-26 Cognitive function; LUSC cis rs2046867 0.862 rs67961837 chr3:72840877 T/G cg25664220 chr3:72788482 NA -0.69 -11.58 -0.54 2.57e-26 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg11752832 chr7:134001865 SLC35B4 0.6 9.38 0.46 1.04e-18 Mean platelet volume; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26317613 chr5:79784006 FAM151B -0.41 -6.47 -0.33 3.46e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7824557 0.583 rs2736306 chr8:11239762 A/T cg08975724 chr8:8085496 FLJ10661 0.43 6.13 0.32 2.53e-9 Retinal vascular caliber; LUSC trans rs6601327 0.678 rs10106040 chr8:9612413 C/G cg15556689 chr8:8085844 FLJ10661 0.47 6.51 0.34 2.71e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs11785400 0.701 rs9297967 chr8:143723002 A/C cg10596483 chr8:143751796 JRK 0.52 7.52 0.38 4.98e-13 Schizophrenia; LUSC cis rs13191362 0.507 rs13210000 chr6:163176944 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.61 9.29 0.45 1.99e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9747201 0.926 rs7222764 chr17:80062698 G/A cg18209359 chr17:80159595 CCDC57 0.37 5.75 0.3 2.05e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06788803 chr1:45805948 MUTYH;TOE1 0.45 6.19 0.32 1.76e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6977660 1.000 rs2107403 chr7:19819025 G/C cg05791153 chr7:19748676 TWISTNB 0.54 5.94 0.31 7.08e-9 Thyroid stimulating hormone; LUSC cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg18681998 chr4:17616180 MED28 0.84 15.62 0.65 1.11e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.63 -6.71 -0.34 8.37e-11 Vitiligo; LUSC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.59 -0.38 3.27e-13 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9653442 0.900 rs10194635 chr2:100834217 T/A cg22139774 chr2:100720529 AFF3 -0.46 -8.09 -0.4 1.15e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.5 8.7 0.43 1.56e-16 Total body bone mineral density; LUSC cis rs3091242 0.900 rs1811832 chr1:25753565 G/A cg03538708 chr1:25844672 NA -0.37 -6.01 -0.31 4.92e-9 Erythrocyte sedimentation rate; LUSC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg12963246 chr6:28129442 ZNF389 0.55 7.63 0.39 2.55e-13 Parkinson's disease; LUSC cis rs9311676 0.656 rs11915190 chr3:58409700 G/A cg26110898 chr3:58419937 PDHB 0.4 6.57 0.34 1.89e-10 Systemic lupus erythematosus; LUSC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg23758822 chr17:41437982 NA 1.04 19.77 0.73 3.88e-58 Menopause (age at onset); LUSC cis rs11864453 0.647 rs9941346 chr16:72135707 C/G cg01557791 chr16:72042693 DHODH -0.43 -6.38 -0.33 6.06e-10 Fibrinogen levels; LUSC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg24296786 chr1:45957014 TESK2 0.53 8.13 0.41 8.72e-15 High light scatter reticulocyte count; LUSC cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg01884057 chr2:25150051 NA 0.42 9.13 0.45 6.57e-18 Body mass index; LUSC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.17 -0.32 1.99e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs977987 0.735 rs11149831 chr16:75451461 G/A cg04384234 chr16:75411784 CFDP1 -0.48 -7.42 -0.38 9.78e-13 Dupuytren's disease; LUSC trans rs4729127 1.000 rs75903658 chr7:94006668 A/C cg08120389 chr17:19881268 AKAP10 0.56 5.96 0.31 6.37e-9 Intelligence; LUSC cis rs1997103 0.954 rs1997099 chr7:55405540 T/C cg17469321 chr7:55412551 NA 0.66 10.58 0.5 9.49e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7608623 0.773 rs3795943 chr2:23919630 C/G cg08917208 chr2:24149416 ATAD2B -0.42 -5.74 -0.3 2.12e-8 Obesity-related traits; LUSC cis rs7903847 0.642 rs7084654 chr10:99135262 G/A cg20016023 chr10:99160130 RRP12 -0.34 -8.41 -0.42 1.2e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs4595586 0.525 rs7977228 chr12:39395060 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs877282 0.853 rs7079450 chr10:755932 T/A cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.55 8.31 0.41 2.44e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg09367891 chr1:107599246 PRMT6 0.51 7.92 0.4 3.58e-14 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg12016809 chr21:47604291 C21orf56 0.43 6.41 0.33 5e-10 Testicular germ cell tumor; LUSC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg16447950 chr5:562315 NA -0.55 -7.66 -0.39 2.08e-13 Ulcerative colitis; LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.85 0.54 2.71e-27 Prudent dietary pattern; LUSC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg03709012 chr19:19516395 GATAD2A 0.84 13.93 0.61 4.28e-35 Tonsillectomy; LUSC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg16647868 chr5:131706066 SLC22A5 0.34 5.71 0.3 2.51e-8 Blood metabolite levels; LUSC cis rs4285028 0.747 rs7647351 chr3:121422109 T/C cg11130432 chr3:121712080 ILDR1 -0.53 -7.84 -0.39 6.07e-14 Multiple sclerosis; LUSC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg03213289 chr20:61660250 NA 0.66 13.54 0.6 1.31e-33 Prostate cancer (SNP x SNP interaction); LUSC cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.34 0.37 1.61e-12 Motion sickness; LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg17968037 chr7:100024898 ZCWPW1 0.39 5.96 0.31 6.49e-9 Platelet count; LUSC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg11645453 chr3:52864694 ITIH4 0.34 8.09 0.4 1.13e-14 Bipolar disorder; LUSC cis rs13006833 0.739 rs6434387 chr2:191205969 C/T cg21644426 chr2:191273491 MFSD6 0.46 6.48 0.33 3.29e-10 Urinary metabolites; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.53 0.42 5.04e-16 Prudent dietary pattern; LUSC cis rs1577917 1.000 rs12201571 chr6:86609750 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs5758659 0.737 rs10854749 chr22:42447341 G/T cg05082376 chr22:42548792 NA -0.36 -6.01 -0.31 4.9e-9 Cognitive function; LUSC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg03563238 chr19:33554763 RHPN2 -0.34 -5.9 -0.31 8.78e-9 Colorectal cancer; LUSC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg05738196 chr6:26577821 NA -0.53 -8.15 -0.41 7.36e-15 Schizophrenia; LUSC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg12756686 chr19:29218302 NA -0.57 -6.77 -0.35 5.8e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.75 0.6 2.12e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs9549367 0.789 rs6577031 chr13:113878182 T/C cg00898013 chr13:113819073 PROZ 0.54 8.33 0.41 2.1e-15 Platelet distribution width; LUSC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg03354898 chr7:1950403 MAD1L1 -0.29 -5.71 -0.3 2.43e-8 Schizophrenia; LUSC cis rs13089785 1.000 rs17310144 chr3:123665902 A/C cg02558132 chr3:123411198 MYLK 0.33 5.69 0.3 2.82e-8 Intelligence (multi-trait analysis); LUSC cis rs9790314 0.967 rs1382427 chr3:161032576 T/C cg04691961 chr3:161091175 C3orf57 -0.36 -6.12 -0.32 2.6e-9 Morning vs. evening chronotype; LUSC cis rs7011049 1.000 rs74457055 chr8:53842669 T/G cg26025543 chr8:53854495 NA 0.52 6.3 0.33 9.5e-10 Systolic blood pressure; LUSC cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg04727924 chr7:799746 HEATR2 -0.55 -6.68 -0.34 1e-10 Cerebrospinal P-tau181p levels; LUSC trans rs56176327 0.600 rs7628207 chr3:49754970 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -6.8 -0.35 4.82e-11 Intelligence (multi-trait analysis); LUSC cis rs4076764 0.801 rs6675964 chr1:163375960 A/G cg24596788 chr1:163392923 NA -0.38 -6.48 -0.33 3.3e-10 Motion sickness; LUSC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.47 7.92 0.4 3.52e-14 Bipolar disorder; LUSC cis rs3790645 1.000 rs364977 chr1:26893836 G/A cg17456097 chr1:26900765 RPS6KA1 0.45 6.6 0.34 1.57e-10 Glucose homeostasis traits; LUSC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg01503450 chr10:980765 NA -0.39 -5.72 -0.3 2.34e-8 Eosinophil percentage of granulocytes; LUSC trans rs11976180 0.517 rs6949375 chr7:143773851 T/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.65 -9.53 -0.46 3.45e-19 Obesity-related traits; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg23034840 chr1:205782522 SLC41A1 0.57 7.91 0.4 3.91e-14 Menarche (age at onset); LUSC cis rs931127 0.719 rs7949980 chr11:65445950 T/C cg05805236 chr11:65401703 PCNXL3 -0.42 -7.42 -0.38 9.55e-13 Systemic lupus erythematosus; LUSC cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg15501526 chr10:2543763 NA 0.7 13.48 0.59 2.24e-33 Age-related hearing impairment; LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.12 0.41 9.02e-15 Prudent dietary pattern; LUSC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg21573476 chr21:45109991 RRP1B -0.41 -6.55 -0.34 2.22e-10 Mean corpuscular volume; LUSC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg24110177 chr3:50126178 RBM5 0.56 9.3 0.45 1.83e-18 Intelligence (multi-trait analysis); LUSC cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg24558204 chr6:135376177 HBS1L 0.58 8.6 0.43 3.19e-16 Red blood cell count; LUSC cis rs8017423 0.935 rs2149653 chr14:90669333 G/A cg04374321 chr14:90722782 PSMC1 0.7 10.93 0.51 5.62e-24 Mortality in heart failure; LUSC cis rs6831352 0.918 rs2213035 chr4:100064233 G/A cg13256891 chr4:100009986 ADH5 -0.46 -6.12 -0.32 2.58e-9 Alcohol dependence; LUSC cis rs7759001 0.857 rs10807020 chr6:27356902 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.09e-12 Motion sickness; LUSC cis rs2404602 0.647 rs116090606 chr15:77075209 A/G cg23625390 chr15:77176239 SCAPER -0.65 -10.05 -0.48 5.95e-21 Blood metabolite levels; LUSC cis rs62432291 0.681 rs435521 chr6:159662638 C/T cg14500486 chr6:159655392 FNDC1 0.53 5.99 0.31 5.3e-9 Joint mobility (Beighton score); LUSC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC cis rs12980942 0.810 rs8105901 chr19:41792092 T/A cg25627403 chr19:41769009 HNRNPUL1 0.65 6.9 0.35 2.57e-11 Coronary artery disease; LUSC cis rs11711311 0.826 rs13077644 chr3:113467777 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.8 0.35 4.84e-11 IgG glycosylation; LUSC cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg18681998 chr4:17616180 MED28 0.78 13.81 0.6 1.26e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs634534 0.563 rs470192 chr11:65724291 C/T cg26695010 chr11:65641043 EFEMP2 -0.48 -7.23 -0.37 3.32e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.78 0.51 1.84e-23 Age-related macular degeneration (geographic atrophy); LUSC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.43 6.55 0.34 2.22e-10 Alzheimer's disease (late onset); LUSC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg21699342 chr2:239360505 ASB1 0.43 6.66 0.34 1.14e-10 Multiple system atrophy; LUSC cis rs10992471 0.580 rs7030920 chr9:95122952 A/G cg14631576 chr9:95140430 CENPP -0.39 -6.71 -0.34 8.11e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7267979 0.966 rs2482923 chr20:25308981 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.68 -0.7 7.46e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1577917 0.682 rs6909767 chr6:86228109 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 9.07 0.44 1.07e-17 Response to antipsychotic treatment; LUSC cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs4499344 0.531 rs259247 chr19:33147657 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.71 10.56 0.5 1.13e-22 Mean platelet volume; LUSC cis rs4631830 0.600 rs11004324 chr10:51496623 G/T cg20129853 chr10:51489980 NA -0.38 -7.3 -0.37 2.18e-12 Prostate-specific antigen levels; LUSC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg03433033 chr1:76189801 ACADM -0.72 -9.65 -0.47 1.32e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs708547 0.874 rs1713978 chr4:57875879 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.54 -0.34 2.27e-10 Response to bleomycin (chromatid breaks); LUSC cis rs909341 0.909 rs2236510 chr20:62368804 C/T cg09650180 chr20:62225654 GMEB2 -0.46 -5.94 -0.31 7.16e-9 Atopic dermatitis; LUSC cis rs9616064 0.853 rs7284865 chr22:46996529 C/T cg25730555 chr22:47059586 GRAMD4 0.45 7.13 0.36 6.1e-12 Urate levels in obese individuals; LUSC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg21435336 chr19:17392852 ANKLE1 -0.45 -6.27 -0.32 1.09e-9 Systemic lupus erythematosus; LUSC cis rs2273669 0.667 rs6916819 chr6:109371129 A/G cg05315195 chr6:109294784 ARMC2 -0.51 -5.74 -0.3 2.15e-8 Prostate cancer; LUSC trans rs2739330 0.796 rs2154594 chr22:24254055 A/G cg06437703 chr8:37914619 EIF4EBP1 0.52 8.12 0.41 8.79e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg07636037 chr3:49044803 WDR6 0.64 10.06 0.48 5.76e-21 Parkinson's disease; LUSC cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg16797656 chr11:68205561 LRP5 -0.37 -6.19 -0.32 1.79e-9 Total body bone mineral density; LUSC trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.17 -0.41 6.41e-15 Myopia (pathological); LUSC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg25427524 chr10:38739819 LOC399744 -0.6 -10.93 -0.51 5.53e-24 Extrinsic epigenetic age acceleration; LUSC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg23649088 chr2:200775458 C2orf69 0.55 7.42 0.38 9.66e-13 Schizophrenia; LUSC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.7 0.47 9.26e-20 Intelligence (multi-trait analysis); LUSC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.32 0.67 1.95e-44 Platelet count; LUSC trans rs3942852 0.955 rs1503190 chr11:48117873 A/G cg03929089 chr4:120376271 NA -0.54 -6.2 -0.32 1.7e-9 Acute lymphoblastic leukemia (childhood); LUSC trans rs1997103 1.000 rs6958022 chr7:55397389 G/A cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg22535103 chr8:58192502 C8orf71 -0.65 -7.32 -0.37 1.89e-12 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg12463550 chr7:65579703 CRCP -0.47 -7.1 -0.36 7.74e-12 Aortic root size; LUSC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg24060327 chr5:131705240 SLC22A5 -0.54 -7.7 -0.39 1.59e-13 Breast cancer; LUSC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.56 0.34 2.09e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7909074 0.933 rs879073 chr10:45399882 C/G cg05187965 chr10:45406764 TMEM72 -0.36 -8.42 -0.42 1.11e-15 Mean corpuscular volume; LUSC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg08645402 chr16:4508243 NA 0.46 7.53 0.38 4.92e-13 Schizophrenia; LUSC cis rs10751667 0.600 rs10751672 chr11:948712 T/C ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.62e-9 Alzheimer's disease (late onset); LUSC cis rs983392 0.679 rs603648 chr11:60012673 A/T cg20284999 chr11:59952153 MS4A6A 0.38 6.44 0.33 4.23e-10 Alzheimer's disease (late onset); LUSC cis rs7904368 0.806 rs1130684 chr10:16859335 C/G cg23933602 chr10:16859644 RSU1 0.55 6.68 0.34 9.84e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs13064411 0.696 rs9808893 chr3:113228444 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -7.74 -0.39 1.2e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs9660992 0.542 rs17345153 chr1:205179997 A/G cg21545522 chr1:205238299 TMCC2 0.47 8.69 0.43 1.68e-16 Mean corpuscular volume;Mean platelet volume; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24738475 chr1:89149492 PKN2 0.4 6.14 0.32 2.39e-9 Triglycerides; LUSC trans rs1493916 0.870 rs8097667 chr18:31387003 C/T cg13755796 chr4:20253514 NA -0.41 -6.43 -0.33 4.54e-10 Life satisfaction; LUSC cis rs7580658 0.929 rs4150496 chr2:128029503 C/T cg09760422 chr2:128146352 NA -0.3 -6.79 -0.35 5.16e-11 Protein C levels; LUSC cis rs926938 0.618 rs360624 chr1:115409476 A/C cg12756093 chr1:115239321 AMPD1 0.47 7.22 0.37 3.48e-12 Autism; LUSC cis rs9611519 0.894 rs9611488 chr22:41462592 G/T cg13813247 chr22:41461852 NA -0.37 -6.59 -0.34 1.67e-10 Neuroticism; LUSC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg06582575 chr6:163149167 PACRG;PARK2 1.17 16.0 0.66 3.46e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9325144 0.678 rs7315271 chr12:39164731 A/G cg13010199 chr12:38710504 ALG10B -0.5 -7.68 -0.39 1.75e-13 Morning vs. evening chronotype; LUSC cis rs3770081 1.000 rs59947468 chr2:86289436 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.94 -6.99 -0.36 1.51e-11 Facial emotion recognition (sad faces); LUSC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg25427524 chr10:38739819 LOC399744 -0.67 -12.11 -0.55 3.2e-28 Extrinsic epigenetic age acceleration; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 22.54 0.78 4.72e-69 Prudent dietary pattern; LUSC trans rs10802346 0.514 rs5024440 chr1:246372608 G/C cg13514129 chr1:39547527 MACF1 0.71 11.76 0.54 5.97e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs113835537 0.597 rs3825065 chr11:66311011 A/G cg24851651 chr11:66362959 CCS 0.53 7.94 0.4 3.14e-14 Airway imaging phenotypes; LUSC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg02569458 chr12:86230093 RASSF9 -0.49 -8.25 -0.41 3.64e-15 Major depressive disorder; LUSC cis rs7582180 0.629 rs11682557 chr2:100948008 C/A cg12002119 chr2:101014098 CHST10 0.35 5.78 0.3 1.72e-8 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg15445000 chr17:37608096 MED1 -0.37 -6.64 -0.34 1.29e-10 Glomerular filtration rate (creatinine); LUSC cis rs10761482 0.601 rs7922622 chr10:62207523 C/T cg18175470 chr10:62150864 ANK3 0.47 6.51 0.34 2.7e-10 Schizophrenia; LUSC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg19230755 chr7:65878503 NA 0.42 5.84 0.3 1.25e-8 Aortic root size; LUSC cis rs16976116 0.901 rs28535372 chr15:55500602 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg06634786 chr22:41940651 POLR3H -0.55 -6.33 -0.33 7.74e-10 Vitiligo; LUSC cis rs2050392 0.630 rs303426 chr10:30740379 A/G cg25182066 chr10:30743637 MAP3K8 0.4 6.36 0.33 6.82e-10 Inflammatory bowel disease; LUSC cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.45 0.42 9.13e-16 Menarche (age at onset); LUSC trans rs34421088 0.506 rs2117616 chr8:11145911 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.43 -0.33 4.36e-10 Neuroticism; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg20701977 chr5:180644504 NA 0.72 5.97 0.31 6.12e-9 Body mass index; LUSC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg20891558 chr2:74357851 NA 0.79 13.3 0.59 1.14e-32 Gestational age at birth (maternal effect); LUSC cis rs11105298 0.891 rs10858871 chr12:89871613 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.22 -0.37 3.45e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6782228 0.565 rs67445542 chr3:128330526 T/C cg16766828 chr3:128327626 NA -0.32 -5.83 -0.3 1.28e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg05368731 chr17:41323189 NBR1 0.96 16.31 0.67 2.17e-44 Menopause (age at onset); LUSC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg21573476 chr21:45109991 RRP1B -0.41 -6.66 -0.34 1.11e-10 Mean corpuscular volume; LUSC trans rs853679 0.607 rs13207345 chr6:28265572 C/T cg01620082 chr3:125678407 NA -0.82 -7.72 -0.39 1.35e-13 Depression; LUSC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg04267008 chr7:1944627 MAD1L1 -0.53 -7.68 -0.39 1.82e-13 Schizophrenia; LUSC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg24531977 chr5:56204891 C5orf35 -1.05 -15.07 -0.64 1.63e-39 Type 2 diabetes; LUSC cis rs4474465 0.790 rs4944206 chr11:78263127 T/C cg27205649 chr11:78285834 NARS2 0.52 6.18 0.32 1.82e-9 Alzheimer's disease (survival time); LUSC cis rs9650657 0.538 rs6984496 chr8:10796093 G/T cg27411982 chr8:10470053 RP1L1 -0.46 -7.42 -0.38 1e-12 Neuroticism; LUSC cis rs2637266 1.000 rs11001830 chr10:78346396 G/A cg18941641 chr10:78392320 NA 0.38 7.07 0.36 8.85e-12 Pulmonary function; LUSC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.39 0.56 3.01e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg18512352 chr11:47633146 NA -0.48 -9.51 -0.46 3.84e-19 Subjective well-being; LUSC cis rs10426930 0.700 rs7246791 chr19:5013776 T/C cg25246084 chr19:4971487 KDM4B -0.33 -6.11 -0.32 2.8e-9 Monocyte percentage of white cells; LUSC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg05025164 chr4:1340916 KIAA1530 -0.51 -7.84 -0.39 6.19e-14 Obesity-related traits; LUSC cis rs5167 0.777 rs56784978 chr19:45499388 T/C cg20090143 chr19:45452003 APOC2 0.36 5.91 0.31 8.24e-9 Blood protein levels; LUSC cis rs1018836 0.828 rs2105968 chr8:91591825 A/G cg16814680 chr8:91681699 NA -0.69 -11.17 -0.52 7.74e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs912330 0.529 rs4772100 chr13:99196573 G/T cg07423050 chr13:99094983 FARP1 -0.35 -6.82 -0.35 4.41e-11 Alzheimer's disease; LUSC cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.95 0.7 6.41e-51 Chronic sinus infection; LUSC trans rs11098499 0.863 rs3822191 chr4:120428101 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.18 0.32 1.85e-9 Corneal astigmatism; LUSC cis rs600231 0.651 rs2846862 chr11:65219790 A/G cg21890820 chr11:65308645 LTBP3 0.48 7.23 0.37 3.37e-12 Bone mineral density; LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg25036284 chr2:26402008 FAM59B 0.75 10.93 0.51 5.79e-24 Gut microbiome composition (summer); LUSC cis rs1799949 0.930 rs34210004 chr17:41370337 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.5 8.63 0.43 2.47e-16 Menopause (age at onset); LUSC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg19774624 chr17:42201019 HDAC5 0.51 7.28 0.37 2.43e-12 Red cell distribution width;Reticulocyte count; LUSC cis rs11971779 0.680 rs6962366 chr7:139043867 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs3862435 0.572 rs2601186 chr15:90926921 A/G cg22089800 chr15:90895588 ZNF774 0.57 6.22 0.32 1.48e-9 Response to exercise (triglyceride level interaction); LUSC cis rs12545109 0.800 rs1837620 chr8:57399473 C/A cg09654669 chr8:57350985 NA -0.52 -7.06 -0.36 9.64e-12 Obesity-related traits; LUSC cis rs8044995 0.563 rs56220628 chr16:68384837 G/A cg09835421 chr16:68378352 PRMT7 -0.75 -8.6 -0.43 3.08e-16 Schizophrenia; LUSC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.72 -0.3 2.37e-8 Tonsillectomy; LUSC cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg04450456 chr4:17643702 FAM184B 0.35 5.74 0.3 2.15e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg16325326 chr1:53192061 ZYG11B 0.99 20.34 0.74 2.02e-60 Monocyte count; LUSC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.07 -0.36 8.87e-12 Major depressive disorder; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg16657816 chr16:30905695 BCL7C 0.37 5.98 0.31 5.72e-9 Metabolite levels (Pyroglutamine); LUSC trans rs6076960 0.598 rs3905168 chr20:6226752 C/T cg21095983 chr6:86352623 SYNCRIP 0.5 7.72 0.39 1.35e-13 Smooth-surface caries; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg02353165 chr6:42928485 GNMT 0.71 12.23 0.56 1.13e-28 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.43 7.33 0.37 1.79e-12 Electroencephalogram traits; LUSC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.61e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 7.83 0.39 6.66e-14 Colorectal cancer; LUSC cis rs9287719 0.967 rs6432122 chr2:10753844 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs77741769 0.700 rs7969196 chr12:121377656 A/C cg02403541 chr12:121454288 C12orf43 -0.49 -7.29 -0.37 2.21e-12 Mean corpuscular volume; LUSC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg07701084 chr6:150067640 NUP43 0.52 7.83 0.39 6.48e-14 Lung cancer; LUSC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg20203395 chr5:56204925 C5orf35 -0.76 -10.18 -0.49 2.15e-21 Initial pursuit acceleration; LUSC cis rs2274273 0.870 rs28716725 chr14:55816610 T/C cg04306507 chr14:55594613 LGALS3 0.56 12.92 0.58 2.99e-31 Protein biomarker; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg15242686 chr22:24348715 GSTTP1 0.49 7.83 0.39 6.34e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2625529 0.730 rs6494975 chr15:72177825 T/A cg16672083 chr15:72433130 SENP8 0.47 7.56 0.38 3.94e-13 Red blood cell count; LUSC cis rs7615952 0.932 rs13314869 chr3:125644669 G/A cg02807482 chr3:125708958 NA -0.48 -5.71 -0.3 2.54e-8 Blood pressure (smoking interaction); LUSC cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg03877680 chr5:178157825 ZNF354A -0.78 -10.93 -0.51 5.78e-24 Neutrophil percentage of white cells; LUSC cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg00012203 chr2:219082015 ARPC2 -0.77 -13.86 -0.6 7.77e-35 Colorectal cancer; LUSC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg05347473 chr6:146136440 FBXO30 -0.66 -11.72 -0.54 8.35e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs10904908 0.763 rs359284 chr10:17326756 T/C cg01003015 chr10:17271136 VIM 0.42 5.99 0.31 5.28e-9 Total cholesterol levels;Cholesterol, total; LUSC cis rs6977660 0.714 rs10252597 chr7:19791171 G/T cg05791153 chr7:19748676 TWISTNB -0.79 -8.45 -0.42 8.85e-16 Thyroid stimulating hormone; LUSC cis rs7937682 1.000 rs10502147 chr11:111569931 G/A cg22437258 chr11:111473054 SIK2 -0.48 -6.24 -0.32 1.33e-9 Primary sclerosing cholangitis; LUSC cis rs11676348 0.774 rs57545959 chr2:219047718 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.38 5.89 0.31 9.67e-9 Ulcerative colitis; LUSC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg21724239 chr8:58056113 NA 0.78 8.05 0.4 1.42e-14 Developmental language disorder (linguistic errors); LUSC trans rs12310956 0.510 rs1565026 chr12:33887499 A/G cg26384229 chr12:38710491 ALG10B 0.55 8.63 0.43 2.55e-16 Morning vs. evening chronotype; LUSC cis rs3126085 0.935 rs1390485 chr1:152182168 C/T cg03465714 chr1:152285911 FLG 0.42 5.83 0.3 1.32e-8 Atopic dermatitis; LUSC cis rs7512552 0.839 rs1103115 chr1:150332304 G/A cg15654264 chr1:150340011 RPRD2 0.64 10.58 0.5 9.37e-23 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.84 0.35 3.72e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1691799 0.899 rs1168351 chr12:66752505 A/G cg16791601 chr12:66731901 HELB -0.72 -12.56 -0.57 6.93e-30 White blood cell count (basophil); LUSC trans rs629535 0.814 rs545720 chr8:70063370 T/C cg21567404 chr3:27674614 NA 0.97 15.48 0.65 3.82e-41 Dupuytren's disease; LUSC cis rs2346177 0.580 rs7565770 chr2:46683683 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.64 -10.13 -0.48 3.23e-21 HDL cholesterol; LUSC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg07424592 chr7:64974309 NA 0.7 6.07 0.32 3.39e-9 Diabetic kidney disease; LUSC cis rs7312933 0.612 rs10785334 chr12:42620377 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.46 -6.3 -0.33 9.29e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg04414720 chr1:150670196 GOLPH3L -0.42 -6.4 -0.33 5.4e-10 Tonsillectomy; LUSC cis rs2953145 0.568 rs1133354 chr2:241522450 A/G cg07929629 chr2:241523174 NA 0.58 10.8 0.51 1.67e-23 Bipolar disorder; LUSC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.26 0.64 2.89e-40 Platelet count; LUSC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg03948781 chr1:205179583 DSTYK 0.3 5.65 0.3 3.5e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg23788917 chr6:8435910 SLC35B3 0.5 7.32 0.37 1.83e-12 Motion sickness; LUSC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.83 -0.3 1.31e-8 Platelet count; LUSC trans rs3942852 0.712 rs10742828 chr11:48104555 A/G cg15704280 chr7:45808275 SEPT13 -0.56 -6.95 -0.36 1.97e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs12791968 1.000 rs10838397 chr11:45009133 A/G cg11846598 chr11:44996168 LOC221122 0.64 10.12 0.48 3.54e-21 Inhibitory control; LUSC cis rs2191566 1.000 rs2191566 chr19:44511389 A/C cg03039196 chr19:44506973 ZNF230 -0.39 -6.49 -0.33 3.11e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs7833790 0.777 rs6473301 chr8:82691340 A/G cg17211192 chr8:82754475 SNX16 -0.76 -10.03 -0.48 7.41e-21 Diastolic blood pressure; LUSC cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.03 0.85 2.44e-93 Chronic sinus infection; LUSC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg06481639 chr22:41940642 POLR3H 0.46 5.69 0.3 2.75e-8 Vitiligo; LUSC cis rs185694 1.000 rs185694 chr13:30885223 C/T cg07600127 chr13:30881527 KATNAL1 0.59 6.45 0.33 3.95e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; LUSC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg05834625 chr6:170176447 C6orf70 0.5 7.01 0.36 1.31e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg01416388 chr22:39784598 NA -0.45 -7.64 -0.39 2.39e-13 Intelligence (multi-trait analysis); LUSC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg23649088 chr2:200775458 C2orf69 -0.52 -7.06 -0.36 9.41e-12 Schizophrenia; LUSC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.0 -0.4 2.12e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs453301 0.592 rs4841084 chr8:8883905 C/T cg08975724 chr8:8085496 FLJ10661 0.46 6.65 0.34 1.19e-10 Joint mobility (Beighton score); LUSC cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg07606381 chr6:8435919 SLC35B3 0.73 12.27 0.56 7.85e-29 Motion sickness; LUSC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.66 10.06 0.48 5.71e-21 Monocyte percentage of white cells; LUSC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg26314531 chr2:26401878 FAM59B 0.69 9.14 0.45 6.33e-18 Gut microbiome composition (summer); LUSC trans rs71435601 0.628 rs36047821 chr2:21418719 C/A cg20757404 chr19:378427 NA -0.41 -6.33 -0.33 8.06e-10 Cholesterol, total; LUSC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg22857025 chr5:266934 NA -1.12 -17.02 -0.68 3.33e-47 Breast cancer; LUSC cis rs1045714 0.895 rs73043182 chr7:2646005 C/T cg24848437 chr7:2645542 IQCE 0.61 6.74 0.35 6.84e-11 Urate levels in lean individuals; LUSC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg25019033 chr10:957182 NA -0.53 -7.1 -0.36 7.77e-12 Eosinophil percentage of granulocytes; LUSC cis rs17102423 0.788 rs11158575 chr14:65581665 T/C cg11161011 chr14:65562177 MAX -0.73 -11.08 -0.52 1.66e-24 Obesity-related traits; LUSC cis rs79976124 0.842 rs7760550 chr6:66628788 T/C cg07460842 chr6:66804631 NA 0.66 8.19 0.41 5.69e-15 Type 2 diabetes; LUSC trans rs656319 0.513 rs1484641 chr8:9986524 A/C cg15556689 chr8:8085844 FLJ10661 0.48 6.72 0.35 7.95e-11 Myopia (pathological); LUSC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg04369109 chr6:150039330 LATS1 -0.52 -7.5 -0.38 5.95e-13 Lung cancer; LUSC cis rs11583043 1.000 rs6660290 chr1:101483512 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.42 -5.68 -0.3 2.86e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg24813613 chr7:1882135 MAD1L1 -0.44 -7.31 -0.37 1.99e-12 Bipolar disorder and schizophrenia; LUSC cis rs7264396 0.676 rs6060729 chr20:34557004 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC cis rs7122539 0.734 rs4930391 chr11:66645254 A/G cg24851651 chr11:66362959 CCS -0.55 -9.86 -0.47 2.63e-20 HIV-1 susceptibility; LUSC trans rs12200782 1.000 rs41267923 chr6:26452947 C/T cg11837749 chr1:55047332 ACOT11 0.59 6.11 0.32 2.75e-9 Small cell lung carcinoma; LUSC trans rs10432489 0.708 rs10178270 chr2:181773395 G/C cg04744134 chr19:8408128 KANK3 0.83 6.27 0.32 1.13e-9 QT interval; LUSC cis rs8025790 0.508 rs12902812 chr15:67909279 C/T cg24579218 chr15:68104479 NA -0.35 -5.84 -0.3 1.21e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg07870213 chr5:140052090 DND1 0.79 11.7 0.54 1.01e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10489202 0.686 rs11590282 chr1:167848231 C/T cg24449463 chr1:168025552 DCAF6 -0.58 -6.6 -0.34 1.63e-10 Schizophrenia; LUSC cis rs12618769 0.597 rs3769729 chr2:99102810 T/C cg10123293 chr2:99228465 UNC50 0.45 7.48 0.38 6.81e-13 Bipolar disorder; LUSC cis rs7712401 0.601 rs1990890 chr5:122182970 C/T cg19077854 chr5:122220652 SNX24 0.41 9.22 0.45 3.52e-18 Mean platelet volume; LUSC cis rs11250098 0.541 rs6997997 chr8:10766082 T/C cg21775007 chr8:11205619 TDH -0.5 -6.79 -0.35 4.99e-11 Morning vs. evening chronotype; LUSC cis rs1832871 0.655 rs6920121 chr6:158678504 C/T cg07165851 chr6:158734300 TULP4 -0.51 -7.95 -0.4 2.92e-14 Height; LUSC cis rs713587 0.935 rs11676272 chr2:25141538 A/G cg04586622 chr2:25135609 ADCY3 0.4 8.21 0.41 5.03e-15 Body mass index in non-asthmatics; LUSC cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg23719950 chr11:63933701 MACROD1 -0.63 -8.1 -0.41 1.03e-14 Mean platelet volume; LUSC cis rs1185460 1.000 rs1185460 chr11:118943433 C/T cg01677386 chr11:118938358 VPS11 0.45 6.3 0.33 9.26e-10 Coronary artery disease; LUSC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.52 -0.34 2.63e-10 Menarche (age at onset); LUSC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.06 -0.31 3.66e-9 Alzheimer's disease (late onset); LUSC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg14703610 chr5:56206110 C5orf35 0.39 5.66 0.3 3.2e-8 Coronary artery disease; LUSC cis rs61931739 0.500 rs11053235 chr12:34507899 G/A cg06521331 chr12:34319734 NA -0.41 -6.39 -0.33 5.57e-10 Morning vs. evening chronotype; LUSC cis rs11971779 0.680 rs6467846 chr7:139079385 G/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg22907277 chr7:1156413 C7orf50 0.7 7.5 0.38 5.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.56 0.42 4.2e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9650657 0.769 rs2116094 chr8:10598822 C/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.15 -0.32 2.17e-9 Neuroticism; LUSC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg25427524 chr10:38739819 LOC399744 -0.59 -10.31 -0.49 8.33e-22 Extrinsic epigenetic age acceleration; LUSC trans rs637571 0.544 rs617791 chr11:65702523 C/G cg17712092 chr4:129076599 LARP1B 0.87 13.8 0.6 1.34e-34 Eosinophil percentage of white cells; LUSC trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg15934090 chr1:100435551 SLC35A3 0.47 8.08 0.4 1.21e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.09 -0.48 4.65e-21 Menarche (age at onset); LUSC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg16325326 chr1:53192061 ZYG11B 0.94 17.85 0.7 1.62e-50 Monocyte count; LUSC cis rs1801251 1.000 rs283469 chr2:233656997 G/T cg08000102 chr2:233561755 GIGYF2 0.71 11.71 0.54 9.21e-27 Coronary artery disease; LUSC cis rs9434723 0.841 rs12083129 chr1:9311323 G/A cg04199779 chr1:9294473 H6PD 0.53 5.69 0.3 2.84e-8 Height; LUSC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg23711669 chr6:146136114 FBXO30 0.86 16.15 0.66 8.98e-44 Lobe attachment (rater-scored or self-reported); LUSC trans rs6598955 0.671 rs11247905 chr1:26627907 G/C cg07461501 chr17:79650226 HGS;ARL16 -0.66 -9.0 -0.44 1.77e-17 Obesity-related traits; LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -16.13 -0.66 1.07e-43 Gut microbiome composition (summer); LUSC cis rs9467773 0.596 rs2451751 chr6:26646714 T/C cg11502198 chr6:26597334 ABT1 0.72 12.19 0.56 1.53e-28 Intelligence (multi-trait analysis); LUSC trans rs8073060 0.545 rs3859282 chr17:34006111 T/C cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg01448562 chr3:133502909 NA 0.55 9.1 0.45 8.32e-18 Alcohol consumption (transferrin glycosylation); LUSC trans rs7939886 0.920 rs17150096 chr11:55902996 C/T cg03929089 chr4:120376271 NA 0.77 6.09 0.32 3.03e-9 Myopia (pathological); LUSC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg18876405 chr7:65276391 NA -0.55 -8.79 -0.43 8.32e-17 Aortic root size; LUSC cis rs1371867 0.846 rs1660349 chr8:101319326 G/A cg00191853 chr8:101177733 SPAG1 -0.4 -6.55 -0.34 2.2e-10 Atrioventricular conduction; LUSC cis rs2288073 0.965 rs10192600 chr2:24396680 A/G cg06627628 chr2:24431161 ITSN2 -0.74 -10.05 -0.48 6.28e-21 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg26384229 chr12:38710491 ALG10B -0.82 -14.09 -0.61 1.03e-35 Bladder cancer; LUSC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg10802521 chr3:52805072 NEK4 -0.55 -8.99 -0.44 1.85e-17 Electroencephalogram traits; LUSC cis rs72634258 0.786 rs7523335 chr1:8180210 G/A cg26816564 chr1:7831052 VAMP3 0.47 6.17 0.32 1.92e-9 Inflammatory bowel disease; LUSC trans rs7937682 0.575 rs11604704 chr11:111764396 G/A cg18187862 chr3:45730750 SACM1L -0.51 -6.27 -0.32 1.1e-9 Primary sclerosing cholangitis; LUSC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg17724175 chr1:150552817 MCL1 0.36 6.6 0.34 1.58e-10 Tonsillectomy; LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg08219700 chr8:58056026 NA 0.68 7.92 0.4 3.63e-14 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs1971762 0.583 rs2365345 chr12:54086820 C/T cg23533419 chr12:54090519 NA -0.37 -6.1 -0.32 2.95e-9 Height; LUSC cis rs9902453 0.904 rs4077465 chr17:28300144 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.63 0.5 6.06e-23 Coffee consumption (cups per day); LUSC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg00509249 chr6:109615579 CCDC162 -0.33 -5.91 -0.31 8.64e-9 Reticulocyte fraction of red cells; LUSC trans rs1949829 0.826 rs73341549 chr7:51541468 C/T cg20941110 chr15:83953819 BNC1 0.56 6.05 0.31 3.8e-9 Wegener's granulomatosis; LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg22920501 chr2:26401640 FAM59B 0.74 10.08 0.48 4.8e-21 Gut microbiome composition (summer); LUSC trans rs2790216 0.526 rs1199093 chr10:59896794 C/G cg21551132 chr17:53046152 COX11;STXBP4 -0.39 -6.27 -0.32 1.14e-9 Inflammatory bowel disease; LUSC cis rs13401104 0.796 rs12468256 chr2:237111995 T/C cg19324714 chr2:237145437 ASB18 0.43 5.71 0.3 2.46e-8 Educational attainment; LUSC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.46 -7.39 -0.38 1.15e-12 Alzheimer's disease (late onset); LUSC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg04865166 chr7:105162814 PUS7 0.51 5.71 0.3 2.49e-8 Bipolar disorder (body mass index interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg26708280 chr2:190649305 PMS1;ORMDL1 0.46 6.75 0.35 6.63e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg15369054 chr17:80825471 TBCD 0.7 12.21 0.56 1.28e-28 Breast cancer; LUSC cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg05347473 chr6:146136440 FBXO30 -0.48 -8.35 -0.42 1.89e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs11030122 0.661 rs963998 chr11:4062803 A/G cg18678763 chr11:4115507 RRM1 -0.42 -5.68 -0.3 2.92e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.76 -0.3 1.92e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs1577917 0.958 rs16876530 chr6:86595641 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.34 -0.42 2.03e-15 Response to antipsychotic treatment; LUSC cis rs55665837 0.539 rs10766196 chr11:14913131 A/G cg05501817 chr11:14380813 RRAS2 -0.39 -5.68 -0.3 2.87e-8 Vitamin D levels; LUSC cis rs2742234 0.541 rs7096500 chr10:43712095 C/T cg02780029 chr10:43622663 RET 0.35 5.82 0.3 1.41e-8 Hirschsprung disease; LUSC cis rs908922 0.676 rs4240883 chr1:152526260 C/T cg20991723 chr1:152506922 NA 0.51 9.6 0.47 1.93e-19 Hair morphology; LUSC cis rs3806843 1.000 rs10073974 chr5:140165231 T/C cg19875535 chr5:140030758 IK 0.5 8.24 0.41 3.98e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.21 0.32 1.54e-9 Menopause (age at onset); LUSC cis rs3540 0.618 rs11609 chr15:91043765 C/G cg22089800 chr15:90895588 ZNF774 -0.64 -9.49 -0.46 4.41e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4363385 0.818 rs407103 chr1:153007106 C/T cg00922841 chr1:152955080 SPRR1A 0.41 7.08 0.36 8.35e-12 Inflammatory skin disease; LUSC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs11098499 0.908 rs11729050 chr4:120300066 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.01e-14 Corneal astigmatism; LUSC trans rs1941687 0.505 rs1389534 chr18:31311161 C/G cg27147174 chr7:100797783 AP1S1 0.51 7.78 0.39 9.1e-14 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs4642101 0.680 rs7626609 chr3:12806080 A/G cg24848339 chr3:12840334 CAND2 -0.34 -6.99 -0.36 1.47e-11 QRS complex (12-leadsum); LUSC cis rs7084921 0.608 rs12780510 chr10:101865881 T/C cg02250046 chr10:101825185 CPN1 -0.34 -6.28 -0.33 1.03e-9 Bone mineral density; LUSC cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg26384229 chr12:38710491 ALG10B 0.84 14.49 0.62 3.04e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg18350739 chr11:68623251 NA -0.36 -6.26 -0.32 1.15e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16281248 chr11:64014554 PPP1R14B 0.38 6.28 0.32 1.08e-9 Triglycerides; LUSC cis rs12760731 0.668 rs12073428 chr1:178427933 G/A cg00404053 chr1:178313656 RASAL2 0.48 5.74 0.3 2.17e-8 Obesity-related traits; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg02951883 chr7:2050386 MAD1L1 -0.44 -7.75 -0.39 1.15e-13 Bipolar disorder and schizophrenia; LUSC cis rs7829975 0.560 rs56094035 chr8:8551622 G/A cg06636001 chr8:8085503 FLJ10661 -0.46 -6.51 -0.34 2.78e-10 Mood instability; LUSC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg03433033 chr1:76189801 ACADM 0.8 13.3 0.59 1.11e-32 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1153858 1.000 rs2668747 chr15:45617216 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 7.91 0.4 3.76e-14 Homoarginine levels; LUSC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg10621924 chr7:39171070 POU6F2 -0.48 -7.29 -0.37 2.26e-12 IgG glycosylation; LUSC trans rs7615952 0.673 rs9841194 chr3:125635739 C/T cg07211511 chr3:129823064 LOC729375 -1.05 -12.96 -0.58 2.17e-31 Blood pressure (smoking interaction); LUSC cis rs12681288 0.792 rs12678495 chr8:1000858 C/G cg15309053 chr8:964076 NA 0.34 6.93 0.35 2.11e-11 Schizophrenia; LUSC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg14552801 chr7:65878734 NA -0.45 -6.47 -0.33 3.59e-10 Aortic root size; LUSC cis rs12681287 0.511 rs7839601 chr8:87503839 G/C cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 8.0 0.4 2.07e-14 Parkinson's disease; LUSC cis rs9534288 0.957 rs2404731 chr13:46618384 T/C cg15192986 chr13:46630673 CPB2 -0.73 -11.34 -0.53 2.02e-25 Blood protein levels; LUSC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg16325326 chr1:53192061 ZYG11B -1.0 -20.25 -0.74 4.79e-60 Monocyte count; LUSC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.87 0.6 7.44e-35 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs887829 0.569 rs4663965 chr2:234650604 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -6.96 -0.36 1.82e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs977987 0.843 rs11149824 chr16:75431830 C/G cg03315344 chr16:75512273 CHST6 0.48 9.12 0.45 6.97e-18 Dupuytren's disease; LUSC cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.75 0.35 6.38e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7590368 0.715 rs72779470 chr2:10964057 C/T cg15705551 chr2:10952987 PDIA6 0.57 6.25 0.32 1.28e-9 Educational attainment (years of education); LUSC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg06637938 chr14:75390232 RPS6KL1 -0.5 -8.0 -0.4 2.02e-14 Height; LUSC cis rs6740322 0.895 rs9309097 chr2:43554397 T/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.54 -7.49 -0.38 6.19e-13 Coronary artery disease; LUSC cis rs1670533 1.000 rs10007978 chr4:1060984 A/T cg27284194 chr4:1044797 NA 0.59 8.57 0.42 3.95e-16 Recombination rate (females); LUSC cis rs7607369 0.580 rs7568196 chr2:219652373 G/A cg02176678 chr2:219576539 TTLL4 -0.64 -12.27 -0.56 7.73e-29 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg22496380 chr5:211416 CCDC127 -0.74 -8.57 -0.42 3.87e-16 Breast cancer; LUSC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg00784671 chr22:46762841 CELSR1 -0.48 -6.65 -0.34 1.18e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs4730250 0.802 rs77936580 chr7:106946343 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.83 -0.3 1.29e-8 Osteoarthritis; LUSC trans rs2197308 0.765 rs12230545 chr12:37927114 C/T cg06521331 chr12:34319734 NA 0.41 6.48 0.33 3.2e-10 Morning vs. evening chronotype; LUSC cis rs9902453 1.000 rs56280226 chr17:28429575 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.43 0.42 1.04e-15 Coffee consumption (cups per day); LUSC cis rs7927592 0.913 rs3740629 chr11:68343593 C/T cg16797656 chr11:68205561 LRP5 0.38 6.2 0.32 1.62e-9 Total body bone mineral density; LUSC cis rs6692729 0.933 rs2793461 chr1:227062129 C/A cg10327440 chr1:227177885 CDC42BPA 0.51 7.32 0.37 1.9e-12 Electrodermal activity; LUSC cis rs10979 1.000 rs9496681 chr6:143896964 G/A cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs427941 0.632 rs201490 chr7:101751910 C/T cg06246474 chr7:101738831 CUX1 0.39 6.33 0.33 7.96e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7605827 0.930 rs2003592 chr2:15552153 C/T cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.08e-17 Educational attainment (years of education); LUSC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg13798780 chr7:105162888 PUS7 0.58 6.1 0.32 2.86e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4474465 1.000 rs2063728 chr11:78185636 G/C cg27205649 chr11:78285834 NARS2 -0.49 -5.76 -0.3 1.9e-8 Alzheimer's disease (survival time); LUSC cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.71 0.47 8.52e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7640424 0.620 rs34910554 chr3:107816733 C/T cg09227934 chr3:107805635 CD47 -0.54 -7.83 -0.39 6.71e-14 Body mass index; LUSC cis rs6961069 0.585 rs28645928 chr7:80258497 T/C cg04458919 chr7:80252533 CD36 -0.41 -7.25 -0.37 2.88e-12 Platelet count; LUSC cis rs921968 0.565 rs692049 chr2:219622778 G/A cg02176678 chr2:219576539 TTLL4 -0.56 -9.87 -0.48 2.42e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs10193935 0.901 rs10490552 chr2:42559947 C/T cg27598129 chr2:42591480 NA 0.6 8.57 0.42 3.77e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg01849466 chr14:104193079 ZFYVE21 0.56 9.07 0.44 1.04e-17 Schizophrenia; LUSC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg04450456 chr4:17643702 FAM184B 0.37 6.36 0.33 6.8e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg08917208 chr2:24149416 ATAD2B 0.56 6.36 0.33 6.82e-10 Lymphocyte counts; LUSC cis rs10072221 0.836 rs3886042 chr5:75704199 G/A cg03132911 chr5:75698732 IQGAP2 0.38 6.42 0.33 4.65e-10 Mean platelet volume; LUSC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg13628971 chr7:2884303 GNA12 0.46 6.74 0.35 6.95e-11 Height; LUSC cis rs497273 0.552 rs11065361 chr12:121386709 T/A cg02403541 chr12:121454288 C12orf43 -0.47 -5.73 -0.3 2.26e-8 Systemic lupus erythematosus; LUSC cis rs7953508 0.506 rs768775 chr12:93968197 T/C cg18151635 chr12:93972918 NA -0.62 -8.89 -0.44 3.85e-17 Pubertal anthropometrics; LUSC cis rs56104184 0.830 rs17272658 chr19:49355405 C/T cg15549821 chr19:49342101 PLEKHA4 -0.9 -10.62 -0.5 6.69e-23 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4077468 1.000 rs11801695 chr1:205916175 A/C cg11965913 chr1:205819406 PM20D1 0.43 6.52 0.34 2.59e-10 Cystic fibrosis-related diabetes; LUSC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg12463550 chr7:65579703 CRCP -0.52 -7.54 -0.38 4.53e-13 Aortic root size; LUSC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg00080972 chr5:178986291 RUFY1 0.57 10.07 0.48 5.47e-21 Lung cancer; LUSC trans rs62238980 0.614 rs2899174 chr22:32458789 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg20887711 chr4:1340912 KIAA1530 0.46 7.11 0.36 7.11e-12 Obesity-related traits; LUSC cis rs7249142 0.561 rs4808185 chr19:19296217 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.38 -5.71 -0.3 2.52e-8 IgG glycosylation; LUSC cis rs2749592 0.513 rs9417249 chr10:37837155 C/T cg25427524 chr10:38739819 LOC399744 0.4 6.75 0.35 6.39e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs709400 0.628 rs4906321 chr14:103878882 C/T cg12935359 chr14:103987150 CKB -0.47 -7.02 -0.36 1.26e-11 Body mass index; LUSC cis rs6964587 0.626 rs6951795 chr7:91543764 T/C cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg04315214 chr1:2043799 PRKCZ 0.46 9.6 0.47 1.96e-19 Height; LUSC cis rs11077998 0.967 rs4789788 chr17:80510285 C/T cg10255544 chr17:80519551 FOXK2 -0.38 -6.26 -0.32 1.17e-9 Reticulocyte fraction of red cells; LUSC trans rs7618501 0.602 rs2624853 chr3:50128893 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -9.73 -0.47 7.36e-20 Intelligence (multi-trait analysis); LUSC cis rs6500395 1.000 rs9936004 chr16:48566088 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.54 0.34 2.25e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7246657 1.000 rs1823061 chr19:37800626 G/A cg23950597 chr19:37808831 NA -0.64 -7.47 -0.38 6.98e-13 Coronary artery calcification; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08348959 chr3:10290087 TATDN2 -0.42 -6.36 -0.33 6.59e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg15997130 chr1:24165203 NA 0.52 8.61 0.43 2.88e-16 Immature fraction of reticulocytes; LUSC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.2 -0.41 5.37e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg06108461 chr20:60628389 TAF4 -1.01 -17.28 -0.69 2.91e-48 Body mass index; LUSC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg13770153 chr20:60521292 NA -0.63 -8.38 -0.42 1.45e-15 Body mass index; LUSC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg18230493 chr5:56204884 C5orf35 -0.58 -9.08 -0.44 9.62e-18 Coronary artery disease; LUSC cis rs6669919 0.516 rs11577717 chr1:211668920 C/T cg10512769 chr1:211675356 NA -0.3 -7.07 -0.36 9.07e-12 Intelligence (multi-trait analysis); LUSC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 14.07 0.61 1.24e-35 Platelet count; LUSC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg03929089 chr4:120376271 NA -1.03 -20.21 -0.74 7.12e-60 Height; LUSC trans rs6951245 0.554 rs10270249 chr7:1151886 G/T cg13565492 chr6:43139072 SRF -0.73 -10.95 -0.51 4.92e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg26380479 chr7:97908229 NA -0.27 -6.08 -0.32 3.21e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14158573 chr20:17549682 DSTN 0.37 6.51 0.34 2.72e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs66569888 0.507 rs11673736 chr2:106886935 T/C cg00318621 chr2:106887213 NA -0.36 -6.54 -0.34 2.37e-10 Facial morphology (factor 23); LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg00080972 chr5:178986291 RUFY1 0.56 10.12 0.48 3.51e-21 Lung cancer; LUSC trans rs7613875 0.620 rs7430334 chr3:50078221 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.83 -0.39 6.55e-14 Body mass index; LUSC cis rs11209002 0.911 rs10889656 chr1:67594559 A/G cg02640540 chr1:67518911 SLC35D1 -0.58 -6.46 -0.33 3.68e-10 Crohn's disease; LUSC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg15110403 chr19:17392923 ANKLE1 -0.59 -8.2 -0.41 5.07e-15 Systemic lupus erythematosus; LUSC cis rs6733011 0.578 rs4851170 chr2:99504323 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 0.49 7.07 0.36 9.14e-12 Bipolar disorder; LUSC cis rs8060686 0.516 rs7189794 chr16:68277727 T/C cg09835421 chr16:68378352 PRMT7 -0.51 -6.28 -0.32 1.06e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9837602 1.000 rs7620228 chr3:99790332 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.24 0.32 1.31e-9 Breast cancer; LUSC cis rs7572644 0.699 rs1395324 chr2:28276643 C/G cg27432699 chr2:27873401 GPN1 -0.53 -7.13 -0.36 6.43e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg17911788 chr17:44343683 NA 0.31 5.89 0.31 9.19e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs708547 0.581 rs13121027 chr4:57813369 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.41 6.04 0.31 4.01e-9 Response to bleomycin (chromatid breaks); LUSC cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.14 -0.32 2.38e-9 IgG glycosylation; LUSC cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg19077165 chr18:44547161 KATNAL2 -0.39 -5.85 -0.3 1.16e-8 Personality dimensions; LUSC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg14895029 chr7:2775587 GNA12 -0.43 -6.8 -0.35 4.89e-11 Height; LUSC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.32 0.56 5.46e-29 Prudent dietary pattern; LUSC cis rs2191566 0.540 rs436739 chr19:44495553 A/G cg18700516 chr19:44507157 ZNF230 0.41 5.68 0.3 2.96e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg10802521 chr3:52805072 NEK4 -0.45 -7.04 -0.36 1.1e-11 Electroencephalogram traits; LUSC cis rs9733 0.650 rs11204668 chr1:150543686 G/A cg04414720 chr1:150670196 GOLPH3L -0.45 -6.92 -0.35 2.35e-11 Tonsillectomy; LUSC cis rs12973672 0.812 rs113185571 chr19:35758929 C/T cg12095397 chr19:35769544 USF2 0.42 6.36 0.33 6.76e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6964587 0.869 rs10241720 chr7:91527367 G/T cg17063962 chr7:91808500 NA -0.53 -8.09 -0.4 1.12e-14 Breast cancer; LUSC cis rs897984 0.520 rs4889534 chr16:30865440 T/C cg02466173 chr16:30829666 NA 0.55 9.26 0.45 2.55e-18 Dementia with Lewy bodies; LUSC cis rs4588572 0.570 rs2115433 chr5:77700363 C/T cg11547950 chr5:77652471 NA -0.41 -6.32 -0.33 8.6e-10 Triglycerides; LUSC cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg03676636 chr4:99064102 C4orf37 0.28 5.95 0.31 6.87e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.07 -0.44 1.01e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6060717 0.553 rs2590958 chr20:34616590 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -6.35 -0.33 7.18e-10 Hip circumference adjusted for BMI; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg25739518 chr22:18560665 PEX26 -0.45 -6.79 -0.35 4.99e-11 Electrocardiographic conduction measures; LUSC cis rs9611519 0.780 rs2235849 chr22:41653540 T/G cg03806693 chr22:41940476 POLR3H -0.53 -7.87 -0.4 5.02e-14 Neuroticism; LUSC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg11663144 chr21:46675770 NA -0.41 -7.19 -0.37 4.16e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9398235 0.673 rs73526955 chr6:110699042 C/T cg19196401 chr6:110721138 DDO 0.41 6.37 0.33 6.42e-10 Systemic lupus erythematosus; LUSC cis rs7312933 0.558 rs61926593 chr12:42818912 C/T cg01256987 chr12:42539512 GXYLT1 -0.4 -7.38 -0.37 1.3e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg19709878 chr17:47440040 ZNF652 0.38 5.97 0.31 6.11e-9 Triglycerides; LUSC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.87 -12.35 -0.56 3.98e-29 Platelet count; LUSC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg06287003 chr12:125626642 AACS -0.39 -6.69 -0.34 9.36e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1538970 0.962 rs9429075 chr1:45818421 G/A cg05343316 chr1:45956843 TESK2 0.61 8.47 0.42 7.91e-16 Platelet count; LUSC cis rs662064 0.963 rs10864460 chr1:10563671 C/G cg20482658 chr1:10539492 PEX14 -0.29 -6.54 -0.34 2.31e-10 Asthma; LUSC cis rs9549367 0.789 rs2287250 chr13:113889474 C/T cg18105134 chr13:113819100 PROZ 0.62 9.37 0.46 1.12e-18 Platelet distribution width; LUSC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg12463550 chr7:65579703 CRCP -0.54 -8.14 -0.41 7.78e-15 Aortic root size; LUSC cis rs208520 1.000 rs12193164 chr6:66978962 C/T cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.73e-14 Systolic blood pressure; LUSC cis rs7315438 0.600 rs34843923 chr12:115879150 C/T cg24172291 chr12:115889509 NA -0.33 -5.77 -0.3 1.8e-8 Colorectal cancer; LUSC cis rs7572644 0.713 rs13026758 chr2:28041273 A/G cg27432699 chr2:27873401 GPN1 0.57 7.28 0.37 2.47e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg24675658 chr1:53192096 ZYG11B -0.64 -10.09 -0.48 4.52e-21 Monocyte count; LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg24813613 chr7:1882135 MAD1L1 -0.47 -8.11 -0.41 1e-14 Bipolar disorder and schizophrenia; LUSC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg00334542 chr7:100209784 MOSPD3 -0.67 -7.84 -0.39 6.08e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7267979 1.000 rs10966 chr20:25282944 A/G cg03522245 chr20:25566470 NINL 0.36 5.77 0.3 1.83e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg00409905 chr10:38381863 ZNF37A -0.36 -6.24 -0.32 1.29e-9 Extrinsic epigenetic age acceleration; LUSC cis rs1670533 1.000 rs11735663 chr4:1051845 C/T cg02018176 chr4:1364513 KIAA1530 0.47 6.49 0.33 3.19e-10 Recombination rate (females); LUSC cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg21535247 chr6:8435926 SLC35B3 0.57 8.9 0.44 3.51e-17 Motion sickness; LUSC cis rs7584330 0.910 rs12465081 chr2:238401784 A/G cg14458575 chr2:238380390 NA 0.65 11.15 0.52 9.15e-25 Prostate cancer; LUSC cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.19 0.64 5.67e-40 Bladder cancer; LUSC cis rs35000415 0.938 rs13236009 chr7:128663173 T/G cg19972273 chr7:128594194 NA 0.68 6.9 0.35 2.56e-11 Systemic lupus erythematosus; LUSC cis rs3850699 0.666 rs7905481 chr10:104476292 T/C cg05855489 chr10:104503620 C10orf26 0.72 11.49 0.53 5.61e-26 Prostate cancer; LUSC cis rs911555 0.723 rs7149767 chr14:103863545 G/A cg24130564 chr14:104152367 KLC1 0.44 6.22 0.32 1.45e-9 Intelligence (multi-trait analysis); LUSC cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -11.26 -0.52 3.88e-25 Systemic lupus erythematosus; LUSC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.48 -6.71 -0.34 8.31e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.3 0.53 2.75e-25 Menopause (age at onset); LUSC cis rs34375054 0.525 rs10846829 chr12:125595058 G/C cg25124228 chr12:125621409 AACS -0.58 -9.59 -0.46 2.15e-19 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9486719 0.843 rs3860231 chr6:97036563 G/A cg06623918 chr6:96969491 KIAA0776 -0.83 -12.1 -0.55 3.35e-28 Migraine;Coronary artery disease; LUSC cis rs9462027 0.651 rs13220394 chr6:34810172 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.75 -0.3 1.97e-8 Systemic lupus erythematosus; LUSC cis rs2944755 0.919 rs2944754 chr8:141574350 A/G cg08444833 chr8:141574162 EIF2C2 0.47 6.05 0.31 3.79e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs2573652 0.722 rs11858932 chr15:100542763 G/A cg00587665 chr15:100533223 ADAMTS17 -0.38 -6.73 -0.35 7.25e-11 Height; LUSC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 7.4 0.38 1.12e-12 Cerebrospinal P-tau181p levels; LUSC cis rs950027 0.620 rs2453533 chr15:45641225 C/A cg21132104 chr15:45694354 SPATA5L1 0.41 6.03 0.31 4.32e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs4970988 0.526 rs6655975 chr1:150542128 A/G cg22823121 chr1:150693482 HORMAD1 -0.48 -6.65 -0.34 1.17e-10 Urate levels; LUSC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs2282300 0.637 rs2065418 chr11:30422068 A/C cg25418670 chr11:30344373 C11orf46 -0.37 -5.96 -0.31 6.45e-9 Morning vs. evening chronotype; LUSC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg23791538 chr6:167370224 RNASET2 0.41 6.7 0.34 8.84e-11 Crohn's disease; LUSC cis rs1568889 0.838 rs12273631 chr11:28042135 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.89 0.58 3.99e-31 Bipolar disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21075237 chr3:57132156 IL17RD 0.46 6.71 0.34 8.56e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs16937 0.711 rs10900462 chr1:205153312 A/G cg00857998 chr1:205179979 DSTYK -0.46 -6.51 -0.34 2.81e-10 Schizophrenia; LUSC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg11752832 chr7:134001865 SLC35B4 0.52 7.99 0.4 2.24e-14 Mean platelet volume; LUSC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg00074818 chr8:8560427 CLDN23 0.57 9.63 0.47 1.54e-19 Obesity-related traits; LUSC cis rs4901869 0.966 rs12893803 chr14:59329655 T/C cg02291164 chr14:59296302 NA 0.56 10.53 0.5 1.45e-22 Panic disorder; LUSC cis rs870825 0.616 rs2090589 chr4:185647731 A/G cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC trans rs8040855 0.965 rs6496766 chr15:85702375 C/A cg00988175 chr11:59481031 OR10V1 -0.29 -6.21 -0.32 1.53e-9 Bulimia nervosa; LUSC cis rs9814567 1.000 rs9851441 chr3:134315091 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.72 -0.6 2.84e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6120849 0.754 rs6120812 chr20:33629427 T/C cg24642439 chr20:33292090 TP53INP2 0.6 6.58 0.34 1.8e-10 Protein C levels; LUSC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg13395646 chr4:1353034 KIAA1530 -0.58 -9.24 -0.45 3.06e-18 Obesity-related traits; LUSC cis rs7582720 1.000 rs72936856 chr2:203775712 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.38 0.42 1.49e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs926938 0.521 rs360649 chr1:115439668 G/C cg12756093 chr1:115239321 AMPD1 0.44 6.49 0.33 3.14e-10 Autism; LUSC cis rs981844 1.000 rs116588966 chr4:154664794 T/C cg14289246 chr4:154710475 SFRP2 0.46 5.72 0.3 2.41e-8 Response to statins (LDL cholesterol change); LUSC cis rs9987353 0.519 rs11779181 chr8:9063027 A/G cg15556689 chr8:8085844 FLJ10661 0.41 5.76 0.3 1.93e-8 Recombination measurement; LUSC cis rs2370759 1.000 rs2225152 chr10:32574759 T/C cg01819863 chr10:32635814 EPC1 1.08 13.45 0.59 2.87e-33 Sexual dysfunction (female); LUSC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg22508957 chr16:3507546 NAT15 0.64 10.58 0.5 9.09e-23 Tuberculosis; LUSC trans rs57221529 0.766 rs12519763 chr5:559145 C/T cg25482853 chr8:67687455 SGK3 1.19 19.12 0.72 1.43e-55 Lung disease severity in cystic fibrosis; LUSC cis rs1865721 0.771 rs727893 chr18:73136931 G/A cg26385618 chr18:73139727 C18orf62 -0.54 -9.86 -0.47 2.71e-20 Intelligence; LUSC cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.5 7.46 0.38 7.54e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs8077889 0.871 rs11079838 chr17:41898971 G/A cg26893861 chr17:41843967 DUSP3 0.88 13.8 0.6 1.38e-34 Triglycerides; LUSC trans rs61931739 0.500 rs11053211 chr12:34464334 T/C cg13010199 chr12:38710504 ALG10B 0.58 9.26 0.45 2.59e-18 Morning vs. evening chronotype; LUSC cis rs611744 0.517 rs62537573 chr8:109269281 C/T cg21045802 chr8:109455806 TTC35 0.46 7.12 0.36 6.47e-12 Dupuytren's disease; LUSC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg17279839 chr7:150038598 RARRES2 0.4 6.22 0.32 1.46e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs6121246 0.567 rs6060295 chr20:30198473 C/T cg13852791 chr20:30311386 BCL2L1 0.75 8.59 0.43 3.47e-16 Mean corpuscular hemoglobin; LUSC cis rs5769707 0.732 rs135865 chr22:50004829 G/A cg20744362 chr22:50050164 C22orf34 0.4 7.64 0.39 2.26e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs8072100 0.967 rs4239163 chr17:45755954 C/T cg08085267 chr17:45401833 C17orf57 -0.56 -9.09 -0.45 9.14e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg16230307 chr14:35515116 FAM177A1 0.77 8.84 0.44 5.41e-17 Psoriasis; LUSC cis rs955333 0.685 rs884924 chr6:154894207 A/G cg20019720 chr6:154832845 CNKSR3 0.44 6.31 0.33 8.88e-10 Diabetic kidney disease; LUSC cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.49 0.56 1.26e-29 Motion sickness; LUSC trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg17470723 chr8:74884337 TCEB1 0.52 8.03 0.4 1.72e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg19723775 chr5:179050963 HNRNPH1 -0.37 -5.76 -0.3 1.88e-8 Lung cancer; LUSC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg09365446 chr1:150670422 GOLPH3L -0.4 -5.94 -0.31 7.35e-9 Tonsillectomy; LUSC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg27432699 chr2:27873401 GPN1 -0.56 -8.36 -0.42 1.69e-15 Total body bone mineral density; LUSC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg16447950 chr5:562315 NA -0.57 -6.87 -0.35 3.21e-11 Lung disease severity in cystic fibrosis; LUSC cis rs13064411 0.696 rs6768648 chr3:113234141 C/G cg18753928 chr3:113234510 CCDC52 -0.49 -7.61 -0.38 2.76e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs752010 0.619 rs7539238 chr1:42113572 A/C cg06885757 chr1:42089581 HIVEP3 0.57 11.69 0.54 1.08e-26 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs9560113 0.960 rs9560102 chr13:112173825 G/A cg14154082 chr13:112174009 NA 0.38 7.95 0.4 2.97e-14 Menarche (age at onset); LUSC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg01181863 chr3:195395398 SDHAP2 -0.59 -8.04 -0.4 1.53e-14 Pancreatic cancer; LUSC cis rs72781680 0.948 rs72790326 chr2:24126153 C/T cg08917208 chr2:24149416 ATAD2B 0.89 10.1 0.48 4.26e-21 Lymphocyte counts; LUSC cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg05555928 chr11:63887634 MACROD1 -0.46 -6.16 -0.32 2.12e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs7188861 0.681 rs55752638 chr16:11409493 T/A cg00044050 chr16:11439710 C16orf75 0.58 5.86 0.31 1.1e-8 HDL cholesterol; LUSC cis rs34330 0.562 rs12229100 chr12:12865836 A/G cg04607235 chr12:12878440 APOLD1 0.52 5.93 0.31 7.67e-9 Systemic lupus erythematosus; LUSC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg18230493 chr5:56204884 C5orf35 -0.88 -13.27 -0.59 1.42e-32 Initial pursuit acceleration; LUSC cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg11266682 chr4:10021025 SLC2A9 0.52 9.64 0.47 1.47e-19 Bone mineral density; LUSC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg26597838 chr10:835615 NA 0.79 9.74 0.47 6.95e-20 Eosinophil percentage of granulocytes; LUSC cis rs8072100 0.837 rs62074055 chr17:45771933 G/C cg19784903 chr17:45786737 TBKBP1 -0.38 -5.84 -0.3 1.23e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2018683 0.707 rs917215 chr7:28971367 C/T cg19402173 chr7:128379420 CALU -0.46 -7.07 -0.36 9.25e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg13453750 chr1:205783389 SLC41A1 -0.33 -6.48 -0.33 3.23e-10 Menarche (age at onset); LUSC trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg03929089 chr4:120376271 NA 0.69 7.76 0.39 1.04e-13 Axial length; LUSC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg02423579 chr7:2872169 GNA12 0.49 7.29 0.37 2.2e-12 Height; LUSC cis rs7824557 0.602 rs35807737 chr8:11204411 C/G cg21293242 chr8:11204541 TDH 0.31 5.66 0.3 3.34e-8 Retinal vascular caliber; LUSC cis rs4654899 0.664 rs10799665 chr1:21152640 C/T cg01072550 chr1:21505969 NA -0.43 -6.44 -0.33 4.15e-10 Superior frontal gyrus grey matter volume; LUSC cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg02153584 chr22:29168773 CCDC117 -0.59 -9.04 -0.44 1.27e-17 Lymphocyte counts; LUSC cis rs1595825 0.891 rs7580003 chr2:198517893 C/T cg00982548 chr2:198649783 BOLL -0.52 -6.63 -0.34 1.32e-10 Ulcerative colitis; LUSC cis rs9473147 0.543 rs4711880 chr6:47480676 A/G cg12968598 chr6:47444699 CD2AP 0.53 8.07 0.4 1.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg13319975 chr6:146136371 FBXO30 0.5 7.84 0.39 6.2e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg03609598 chr5:56110824 MAP3K1 -0.35 -5.64 -0.3 3.57e-8 Initial pursuit acceleration; LUSC cis rs67981189 0.593 rs10140225 chr14:71491121 T/C cg15816911 chr14:71606274 NA 0.33 5.86 0.31 1.1e-8 Schizophrenia; LUSC cis rs7223966 1.000 rs8070650 chr17:61744040 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.74 0.35 6.99e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg21724239 chr8:58056113 NA 0.57 6.6 0.34 1.61e-10 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.935 rs1680072 chr4:1281695 T/G cg13395646 chr4:1353034 KIAA1530 0.58 8.88 0.44 4.28e-17 Obesity-related traits; LUSC trans rs11949289 0.933 rs2195357 chr5:28349030 G/A cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.57e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11711311 1.000 rs9828449 chr3:113518602 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.82 -0.3 1.41e-8 IgG glycosylation; LUSC cis rs7568458 0.684 rs6731700 chr2:85760991 C/G cg02493740 chr2:85810744 VAMP5 -0.5 -8.59 -0.43 3.45e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11758351 1.000 rs3734530 chr6:26195408 G/C cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC cis rs1670533 1.000 rs7660779 chr4:1075940 A/G cg27284194 chr4:1044797 NA 0.58 8.68 0.43 1.74e-16 Recombination rate (females); LUSC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg08219700 chr8:58056026 NA 0.47 5.94 0.31 7.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs7584330 0.554 rs3751109 chr2:238427194 T/C cg16989719 chr2:238392110 NA -0.43 -6.24 -0.32 1.34e-9 Prostate cancer; LUSC cis rs9649213 0.586 rs11768599 chr7:97974555 C/T cg08684580 chr7:98029266 BAIAP2L1 0.39 5.96 0.31 6.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13064411 0.696 rs9814395 chr3:113188885 C/T cg18753928 chr3:113234510 CCDC52 -0.54 -8.36 -0.42 1.7e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.85 -0.35 3.57e-11 Monocyte percentage of white cells; LUSC cis rs765787 0.530 rs2413785 chr15:45530381 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.93 -0.44 2.98e-17 Uric acid levels; LUSC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg19748678 chr4:122722346 EXOSC9 0.71 10.58 0.5 9.28e-23 Type 2 diabetes; LUSC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11890956 chr21:40555474 PSMG1 -0.71 -10.97 -0.51 4.14e-24 Menarche (age at onset); LUSC cis rs2797160 0.651 rs6939969 chr6:126034563 C/T cg05901451 chr6:126070800 HEY2 0.77 12.54 0.57 8.32e-30 Endometrial cancer; LUSC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg08798685 chr6:27730294 NA 0.66 6.06 0.31 3.6e-9 Depression; LUSC trans rs743446 0.518 rs2836554 chr21:39973669 C/G cg01504248 chr4:77345848 NA -0.26 -5.95 -0.31 6.67e-9 Neonatal lupus; LUSC cis rs1348850 0.914 rs4893961 chr2:178411075 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 7.39 0.37 1.22e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.85 0.47 2.83e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2445762 0.659 rs12441170 chr15:51653898 G/A cg07517944 chr15:51633816 GLDN 0.39 6.39 0.33 5.66e-10 Hormone measurements; LUSC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg06022373 chr22:39101656 GTPBP1 0.78 11.85 0.54 2.72e-27 Menopause (age at onset); LUSC cis rs7666738 0.606 rs3846447 chr4:99099907 G/A cg03676636 chr4:99064102 C4orf37 0.28 5.9 0.31 8.72e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg00530320 chr1:46809349 NSUN4 -0.57 -8.89 -0.44 4.03e-17 Menopause (age at onset); LUSC cis rs6977940 0.818 rs55752034 chr7:2895416 T/C cg19731401 chr7:2775893 GNA12 0.65 7.3 0.37 2.09e-12 White matter integrity; LUSC cis rs6969780 0.915 rs11983200 chr7:27186596 A/G cg26364809 chr7:27145159 NA -0.6 -6.05 -0.31 3.79e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs899997 0.862 rs12912524 chr15:78952756 G/A cg04896959 chr15:78267971 NA 0.43 8.57 0.42 3.88e-16 Coronary artery disease or large artery stroke; LUSC cis rs240764 0.687 rs1336245 chr6:101197640 A/T cg09795085 chr6:101329169 ASCC3 -0.43 -6.27 -0.32 1.11e-9 Neuroticism; LUSC trans rs1908814 0.516 rs7812563 chr8:11794488 T/G cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.22e-15 Neuroticism; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg14159672 chr1:205819179 PM20D1 -0.82 -14.76 -0.63 2.62e-38 Menarche (age at onset); LUSC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg05738196 chr6:26577821 NA 0.53 8.32 0.41 2.23e-15 Schizophrenia; LUSC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg02807482 chr3:125708958 NA -0.54 -6.65 -0.34 1.16e-10 Blood pressure (smoking interaction); LUSC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 10.3 0.49 8.64e-22 Alzheimer's disease; LUSC cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg13010199 chr12:38710504 ALG10B 0.61 9.21 0.45 3.8e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs12541635 0.677 rs6469032 chr8:107057509 A/T cg10147462 chr8:107024639 NA 0.66 13.82 0.6 1.17e-34 Age of smoking initiation; LUSC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg07677032 chr17:61819896 STRADA 0.52 8.79 0.43 8.03e-17 Prudent dietary pattern; LUSC trans rs11098499 0.954 rs4309825 chr4:120314881 C/T cg25214090 chr10:38739885 LOC399744 -0.5 -7.76 -0.39 1.03e-13 Corneal astigmatism; LUSC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg08975724 chr8:8085496 FLJ10661 -0.48 -7.13 -0.36 6.22e-12 Joint mobility (Beighton score); LUSC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg22963979 chr7:1858916 MAD1L1 -0.62 -9.88 -0.48 2.24e-20 Bipolar disorder and schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07435294 chr11:65554356 OVOL1 -0.48 -6.07 -0.32 3.5e-9 Bipolar disorder and schizophrenia; LUSC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg05132306 chr1:1846340 CALML6 -0.33 -8.47 -0.42 8.1e-16 Body mass index; LUSC cis rs686320 1.000 rs667196 chr11:65247092 A/T cg21890820 chr11:65308645 LTBP3 0.75 7.48 0.38 6.58e-13 Hip circumference adjusted for BMI; LUSC cis rs2479724 0.905 rs2274578 chr6:41888827 C/G cg17623882 chr6:41773611 USP49 -0.63 -10.61 -0.5 7.44e-23 Menarche (age at onset); LUSC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg11812906 chr14:75593930 NEK9 0.66 11.4 0.53 1.2e-25 Height; LUSC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg07716408 chr11:68623521 NA -0.33 -6.15 -0.32 2.24e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs8040855 0.860 rs7172266 chr15:85716213 C/T cg04831495 chr15:85060580 GOLGA6L5 0.4 5.82 0.3 1.42e-8 Bulimia nervosa; LUSC cis rs6681460 0.966 rs1325261 chr1:67110516 G/A cg02459107 chr1:67143332 SGIP1 0.47 8.57 0.42 3.81e-16 Presence of antiphospholipid antibodies; LUSC cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.67 0.5 4.55e-23 Bone mineral density; LUSC cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg15423357 chr2:25149977 NA 0.45 8.94 0.44 2.63e-17 Body mass index; LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 13.48 0.59 2.26e-33 Alzheimer's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23068124 chr14:58711505 PSMA3 0.46 6.54 0.34 2.3e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg03929089 chr4:120376271 NA -0.44 -6.19 -0.32 1.72e-9 HDL cholesterol; LUSC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg06238570 chr21:40685208 BRWD1 0.55 8.52 0.42 5.69e-16 Menarche (age at onset); LUSC cis rs965469 1.000 rs6139088 chr20:3329063 G/A cg25506879 chr20:3388711 C20orf194 -0.51 -5.65 -0.3 3.48e-8 IFN-related cytopenia; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg00945038 chr17:61921165 SMARCD2 0.53 9.28 0.45 2.15e-18 Prudent dietary pattern; LUSC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg11812906 chr14:75593930 NEK9 0.54 8.89 0.44 3.88e-17 Coronary artery disease; LUSC cis rs936229 0.690 rs2472300 chr15:75033909 A/G cg10253484 chr15:75165896 SCAMP2 -0.48 -6.5 -0.34 2.87e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg04369109 chr6:150039330 LATS1 -0.56 -8.37 -0.42 1.55e-15 Lung cancer; LUSC cis rs7147624 1.000 rs10083363 chr14:66200768 G/A cg03016385 chr14:66212404 NA -0.78 -8.28 -0.41 2.9e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg26668828 chr6:292823 DUSP22 -0.52 -7.95 -0.4 2.99e-14 Menopause (age at onset); LUSC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg08200582 chr11:442649 ANO9 -0.52 -6.1 -0.32 3.02e-9 Body mass index; LUSC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg06544989 chr22:39130855 UNC84B 0.33 5.65 0.3 3.51e-8 Menopause (age at onset); LUSC cis rs2963155 0.518 rs55817235 chr5:142765733 C/T cg17617527 chr5:142782415 NR3C1 0.72 8.29 0.41 2.88e-15 Breast cancer; LUSC cis rs700651 0.821 rs700690 chr2:198727626 A/G cg00792783 chr2:198669748 PLCL1 0.43 5.68 0.3 2.9e-8 Intracranial aneurysm; LUSC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg03709012 chr19:19516395 GATAD2A 0.75 11.61 0.54 2.13e-26 Tonsillectomy; LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 12.96 0.58 2.16e-31 Platelet count; LUSC cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg25427524 chr10:38739819 LOC399744 -0.72 -13.42 -0.59 3.74e-33 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg12463550 chr7:65579703 CRCP -0.41 -5.92 -0.31 7.78e-9 Aortic root size; LUSC trans rs17685 0.712 rs10271413 chr7:75754858 G/A cg19862616 chr7:65841803 NCRNA00174 1.11 18.62 0.71 1.39e-53 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1728785 1.000 rs1170443 chr16:68573295 G/C cg02972257 chr16:68554789 NA -0.48 -6.07 -0.32 3.39e-9 Ulcerative colitis; LUSC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg08280861 chr8:58055591 NA 0.53 5.81 0.3 1.46e-8 Developmental language disorder (linguistic errors); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11310629 chr13:45991975 SLC25A30 0.41 6.21 0.32 1.57e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs617219 0.890 rs10060869 chr5:78489979 A/G cg24856658 chr5:78533917 JMY -0.3 -5.86 -0.31 1.13e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.36 0.33 6.58e-10 Personality dimensions; LUSC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg04727924 chr7:799746 HEATR2 -0.57 -5.95 -0.31 6.85e-9 Cerebrospinal P-tau181p levels; LUSC cis rs9926296 0.609 rs4785710 chr16:89796756 C/T cg01097406 chr16:89675127 NA 0.32 6.27 0.32 1.14e-9 Vitiligo; LUSC cis rs67539049 1.000 rs56138616 chr8:11287550 A/G cg02771117 chr8:11279352 FAM167A;C8orf12 -0.42 -5.97 -0.31 6.18e-9 Itch intensity from mosquito bite; LUSC cis rs2286885 0.965 rs10760440 chr9:129250831 C/T cg15282417 chr9:129245246 FAM125B 0.4 6.61 0.34 1.54e-10 Intraocular pressure; LUSC cis rs2348418 0.966 rs11049699 chr12:28688420 C/T cg13890972 chr12:28721907 NA -0.34 -5.74 -0.3 2.1e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs7793919 0.726 rs10232008 chr7:4783206 T/G cg00064840 chr7:4784485 FOXK1 0.3 5.68 0.3 2.88e-8 Mosquito bite size; LUSC trans rs3733585 0.753 rs1122141 chr4:9947278 T/C cg26043149 chr18:55253948 FECH -0.44 -6.7 -0.34 9.06e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg23422044 chr7:1970798 MAD1L1 -0.54 -6.02 -0.31 4.71e-9 Bipolar disorder; LUSC cis rs4242434 0.819 rs7843128 chr8:22473465 T/C cg03733263 chr8:22462867 KIAA1967 0.89 15.58 0.65 1.59e-41 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs9902453 0.868 rs8066602 chr17:28523085 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.36 0.46 1.21e-18 Coffee consumption (cups per day); LUSC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2486288 0.656 rs1706770 chr15:45575062 T/C cg09092052 chr15:45571596 NA 0.46 6.29 0.33 9.68e-10 Glomerular filtration rate; LUSC cis rs62400317 0.793 rs6924185 chr6:45017228 C/A cg18551225 chr6:44695536 NA -0.42 -6.97 -0.36 1.69e-11 Total body bone mineral density; LUSC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg09877947 chr5:131593287 PDLIM4 0.45 7.37 0.37 1.4e-12 Breast cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07521723 chr16:27280150 NSMCE1 0.71 6.05 0.31 3.8e-9 Cognitive performance; LUSC cis rs10927875 1.000 rs4307563 chr1:16313788 C/T cg22431228 chr1:16359049 CLCNKA 0.45 8.69 0.43 1.6e-16 Dilated cardiomyopathy; LUSC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg24531977 chr5:56204891 C5orf35 -0.52 -7.68 -0.39 1.82e-13 Coronary artery disease; LUSC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg03929089 chr4:120376271 NA -1.03 -20.22 -0.74 6e-60 Height; LUSC cis rs478304 0.651 rs11227281 chr11:65496558 T/C cg10604040 chr11:65559109 OVOL1 0.31 5.72 0.3 2.34e-8 Acne (severe); LUSC cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg13902645 chr11:5959945 NA 0.54 7.18 0.37 4.46e-12 DNA methylation (variation); LUSC cis rs8072100 0.701 rs4794053 chr17:45769551 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.4 -6.19 -0.32 1.77e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs9388451 0.839 rs1811852 chr6:126071575 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.61 -9.61 -0.47 1.87e-19 Brugada syndrome; LUSC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg13206674 chr6:150067644 NUP43 0.6 9.53 0.46 3.38e-19 Lung cancer; LUSC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs1801251 1.000 rs6724117 chr2:233593660 T/G cg25237894 chr2:233734115 C2orf82 0.35 6.48 0.33 3.36e-10 Coronary artery disease; LUSC cis rs11098499 0.863 rs3775847 chr4:120447642 A/C cg24375607 chr4:120327624 NA 0.76 11.14 0.52 1e-24 Corneal astigmatism; LUSC cis rs9463078 0.665 rs9472339 chr6:44711791 A/G cg25276700 chr6:44698697 NA 0.31 6.35 0.33 7.05e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg21644426 chr2:191273491 MFSD6 0.59 9.4 0.46 9.08e-19 Pulse pressure; LUSC cis rs6546886 0.957 rs4853003 chr2:74248871 A/G cg14702570 chr2:74259524 NA -0.31 -5.89 -0.31 9.27e-9 Dialysis-related mortality; LUSC cis rs7789940 0.951 rs7779014 chr7:75975586 C/T cg15798862 chr7:76129360 DTX2 -0.51 -8.54 -0.42 4.77e-16 Multiple sclerosis; LUSC cis rs10504229 0.906 rs7846666 chr8:58172302 T/C cg21724239 chr8:58056113 NA 0.55 6.75 0.35 6.63e-11 Developmental language disorder (linguistic errors); LUSC trans rs17685 0.753 rs2302435 chr7:75676987 G/A cg19862616 chr7:65841803 NCRNA00174 -1.12 -19.49 -0.73 4.76e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg24642439 chr20:33292090 TP53INP2 0.62 9.43 0.46 7.1e-19 Coronary artery disease; LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg20887711 chr4:1340912 KIAA1530 0.46 7.04 0.36 1.07e-11 Obesity-related traits; LUSC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.8 -0.35 4.9e-11 Monocyte percentage of white cells; LUSC cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg24296786 chr1:45957014 TESK2 -0.49 -7.24 -0.37 3.2e-12 High light scatter reticulocyte count; LUSC cis rs4594175 0.926 rs4131365 chr14:51622444 C/T cg23942311 chr14:51606299 NA 0.31 5.86 0.31 1.11e-8 Cancer; LUSC cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg05855489 chr10:104503620 C10orf26 0.51 7.75 0.39 1.1e-13 Arsenic metabolism; LUSC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg13206674 chr6:150067644 NUP43 0.58 9.09 0.45 8.72e-18 Lung cancer; LUSC cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg12573674 chr2:1569213 NA -0.56 -7.97 -0.4 2.61e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs7937682 0.924 rs1784782 chr11:111525764 A/C cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg25204440 chr1:209979598 IRF6 0.53 7.08 0.36 8.6e-12 Cleft lip with or without cleft palate; LUSC cis rs2625529 0.824 rs12917428 chr15:72221998 T/C cg16672083 chr15:72433130 SENP8 -0.52 -7.51 -0.38 5.28e-13 Red blood cell count; LUSC cis rs2439831 0.850 rs61390361 chr15:44159842 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.74 6.54 0.34 2.33e-10 Lung cancer in ever smokers; LUSC cis rs708547 0.792 rs7667084 chr4:57727435 T/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.57 -7.18 -0.37 4.67e-12 Response to bleomycin (chromatid breaks); LUSC cis rs7296418 0.961 rs4275659 chr12:123447928 C/T cg13010344 chr12:123464640 ARL6IP4 0.48 7.43 0.38 8.97e-13 Platelet count; LUSC cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.86e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg04317338 chr11:64019027 PLCB3 0.65 7.32 0.37 1.87e-12 Mean platelet volume; LUSC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg13206674 chr6:150067644 NUP43 -0.53 -8.14 -0.41 8.09e-15 Lung cancer; LUSC cis rs6582630 0.638 rs10880644 chr12:38554959 G/A cg13010199 chr12:38710504 ALG10B 0.47 7.01 0.36 1.33e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg18252515 chr7:66147081 NA -1.18 -13.0 -0.58 1.52e-31 Diabetic kidney disease; LUSC cis rs4499344 0.622 rs7259049 chr19:33056594 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.71 -8.75 -0.43 1.04e-16 Mean platelet volume; LUSC cis rs9486719 1.000 rs2499804 chr6:96861216 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.79 0.47 4.45e-20 Migraine;Coronary artery disease; LUSC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg23978390 chr7:1156363 C7orf50 0.46 6.44 0.33 4.17e-10 Longevity;Endometriosis; LUSC cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg03676636 chr4:99064102 C4orf37 0.27 5.84 0.3 1.24e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs7615316 0.902 rs7610557 chr3:142312371 A/G cg16271453 chr3:142027066 XRN1 -0.36 -6.12 -0.32 2.61e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs193541 0.632 rs246279 chr5:122241263 C/G cg19077854 chr5:122220652 SNX24 -0.43 -5.93 -0.31 7.5e-9 Glucose homeostasis traits; LUSC cis rs853679 0.546 rs493161 chr6:27850714 A/T cg26587870 chr6:27730563 NA -0.65 -5.66 -0.3 3.21e-8 Depression; LUSC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg27539214 chr16:67997921 SLC12A4 -0.57 -7.46 -0.38 7.53e-13 HDL cholesterol;Metabolic syndrome; LUSC trans rs12200782 0.872 rs59438701 chr6:26412527 C/T cg18180407 chr1:55047736 ACOT11 0.44 6.01 0.31 4.8e-9 Small cell lung carcinoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16794633 chr3:143690145 C3orf58 -0.4 -6.53 -0.34 2.47e-10 Electrocardiographic conduction measures; LUSC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg10802521 chr3:52805072 NEK4 -0.48 -7.49 -0.38 6.15e-13 Electroencephalogram traits; LUSC cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg03146154 chr1:46216737 IPP 0.49 7.33 0.37 1.73e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9283706 0.513 rs7707409 chr5:66351889 A/G cg11590213 chr5:66331682 MAST4 0.5 7.44 0.38 8.61e-13 Coronary artery disease; LUSC cis rs10504229 0.679 rs16921676 chr8:58052386 G/T cg22535103 chr8:58192502 C8orf71 -0.59 -6.81 -0.35 4.65e-11 Developmental language disorder (linguistic errors); LUSC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg24562669 chr7:97807699 LMTK2 0.35 6.2 0.32 1.65e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13089785 1.000 rs13092912 chr3:123604942 C/T cg02558132 chr3:123411198 MYLK 0.36 6.25 0.32 1.26e-9 Intelligence (multi-trait analysis); LUSC cis rs1113500 0.702 rs11185262 chr1:108639742 C/T cg11967332 chr1:108735228 SLC25A24 0.4 5.93 0.31 7.61e-9 Growth-regulated protein alpha levels; LUSC cis rs7246967 0.673 rs11881740 chr19:22843844 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs4851254 0.618 rs7572939 chr2:100654914 A/G cg07810366 chr2:100720526 AFF3 -0.46 -5.98 -0.31 5.87e-9 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg06636001 chr8:8085503 FLJ10661 -0.58 -9.02 -0.44 1.49e-17 Mood instability; LUSC cis rs9362426 1.000 rs1203156 chr6:88079694 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.35 5.76 0.3 1.94e-8 Depressive episodes in bipolar disorder; LUSC cis rs13126513 0.519 rs12641768 chr4:100558594 C/A cg05468953 chr4:100565104 NA 0.35 6.59 0.34 1.76e-10 Metabolite levels (MHPG); LUSC cis rs9420 0.961 rs11605731 chr11:57524089 C/G cg02958346 chr11:57425731 CLP1 -0.44 -6.44 -0.33 4.22e-10 Schizophrenia; LUSC cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg14196790 chr5:131705035 SLC22A5 0.52 8.91 0.44 3.46e-17 Blood metabolite levels; LUSC cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -8.24 -0.41 4e-15 Body mass index (adult); LUSC cis rs79387448 0.745 rs59126438 chr2:103165142 T/G cg09003973 chr2:102972529 NA 0.88 8.56 0.42 4.18e-16 Gut microbiota (bacterial taxa); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg13188385 chr3:9291334 SRGAP3 0.45 6.41 0.33 5.09e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs72781680 0.678 rs11125293 chr2:24102423 A/G cg08917208 chr2:24149416 ATAD2B 0.59 6.91 0.35 2.4e-11 Lymphocyte counts; LUSC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -5.96 -0.31 6.29e-9 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7959452 0.640 rs11177599 chr12:69721970 G/A cg22834771 chr12:69754056 YEATS4 -0.45 -6.48 -0.33 3.22e-10 Blood protein levels; LUSC cis rs981844 0.885 rs72731673 chr4:154667446 A/G cg14289246 chr4:154710475 SFRP2 0.48 6.03 0.31 4.26e-9 Response to statins (LDL cholesterol change); LUSC cis rs3101457 0.515 rs4658628 chr1:244516090 T/C cg09033006 chr1:244517177 C1orf100 -0.44 -6.3 -0.33 9.61e-10 Smoking behavior; LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.58 0.67 1.84e-45 Platelet count; LUSC cis rs7223966 0.921 rs2854207 chr17:61947107 C/G cg00945038 chr17:61921165 SMARCD2 0.38 5.68 0.3 2.96e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg05729581 chr11:3078854 CARS -0.55 -8.57 -0.42 3.97e-16 Longevity; LUSC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg19592336 chr6:28129416 ZNF389 0.45 6.0 0.31 5.12e-9 Depression; LUSC cis rs9463078 0.625 rs12190513 chr6:44920679 A/T cg25276700 chr6:44698697 NA 0.28 5.85 0.3 1.17e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4253772 0.530 rs9615955 chr22:46743931 A/G cg18190219 chr22:46762943 CELSR1 -0.61 -6.02 -0.31 4.52e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs877282 0.583 rs10904566 chr10:821662 C/G cg13042288 chr15:90349979 ANPEP -0.43 -6.31 -0.33 9.06e-10 Uric acid levels; LUSC trans rs2288327 0.557 rs7588593 chr2:179352450 T/C cg14011486 chr1:26737247 LIN28 0.78 9.73 0.47 7.51e-20 Atrial fibrillation; LUSC cis rs75804782 0.521 rs56373856 chr2:239437926 C/T cg18131467 chr2:239335373 ASB1 -0.67 -6.01 -0.31 4.73e-9 Morning vs. evening chronotype;Chronotype; LUSC trans rs7726839 0.540 rs3762951 chr5:662613 C/G cg25482853 chr8:67687455 SGK3 1.09 15.86 0.66 1.27e-42 Obesity-related traits; LUSC cis rs11098499 0.618 rs35265692 chr4:120325135 T/C cg24375607 chr4:120327624 NA 0.79 11.89 0.55 2.04e-27 Corneal astigmatism; LUSC cis rs7312933 0.558 rs2178753 chr12:42732804 T/C cg01256987 chr12:42539512 GXYLT1 0.35 6.27 0.32 1.11e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs554111 0.656 rs10753514 chr1:21492531 T/C cg01072550 chr1:21505969 NA 0.39 5.87 0.31 1.05e-8 Facial morphology (factor 17, height of vermillion upper lip); LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg16606324 chr3:10149918 C3orf24 0.58 8.23 0.41 4.27e-15 Alzheimer's disease; LUSC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg06873352 chr17:61820015 STRADA -0.54 -8.62 -0.43 2.75e-16 Height; LUSC cis rs12900413 0.523 rs11636525 chr15:90300478 A/G cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.49 -6.79 -0.35 5e-11 Tonsillectomy; LUSC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg22903471 chr2:27725779 GCKR -0.41 -6.98 -0.36 1.64e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs7589342 0.929 rs6719896 chr2:106428404 C/G cg16077055 chr2:106428750 NCK2 -0.37 -7.13 -0.36 6.27e-12 Addiction; LUSC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg25828334 chr19:18545568 ISYNA1 0.34 5.97 0.31 6.04e-9 Breast cancer; LUSC cis rs2067615 0.579 rs10746066 chr12:107129108 G/A cg15890332 chr12:107067104 RFX4 0.34 6.19 0.32 1.77e-9 Heart rate; LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg07362569 chr17:61921086 SMARCD2 0.38 7.87 0.4 4.99e-14 Prudent dietary pattern; LUSC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg18404041 chr3:52824283 ITIH1 0.45 7.8 0.39 8.03e-14 Bipolar disorder; LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg23173402 chr1:227635558 NA -0.6 -7.21 -0.37 3.66e-12 Major depressive disorder; LUSC cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs2414856 0.510 rs72756994 chr15:64606417 C/G cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg24642439 chr20:33292090 TP53INP2 0.64 9.79 0.47 4.71e-20 Coronary artery disease; LUSC cis rs11112613 0.609 rs2374534 chr12:106047897 A/T cg03607813 chr12:105948248 NA 0.62 7.68 0.39 1.81e-13 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs4285028 0.699 rs1920298 chr3:121597888 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.79 -10.77 -0.51 2.03e-23 Multiple sclerosis; LUSC cis rs7202877 0.706 rs247443 chr16:75465073 G/C cg04384234 chr16:75411784 CFDP1 0.7 9.68 0.47 1.08e-19 Type 2 diabetes;Type 1 diabetes; LUSC cis rs11155671 0.530 rs9969044 chr6:150209204 A/G cg09699651 chr6:150184138 LRP11 0.45 6.99 0.36 1.46e-11 Testicular germ cell tumor; LUSC cis rs9902453 0.765 rs2729448 chr17:28091953 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.24 -0.52 4.38e-25 Coffee consumption (cups per day); LUSC cis rs17253792 0.822 rs17685053 chr14:56125771 T/A cg01858014 chr14:56050164 KTN1 -0.69 -6.06 -0.31 3.61e-9 Putamen volume; LUSC cis rs7264396 0.676 rs6060730 chr20:34558503 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.6 -0.43 3.16e-16 Total cholesterol levels; LUSC trans rs17685 0.712 rs60721456 chr7:75743820 T/A cg19862616 chr7:65841803 NCRNA00174 1.09 17.44 0.69 6.94e-49 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs372883 0.530 rs2832302 chr21:30749793 G/T cg08807101 chr21:30365312 RNF160 -0.63 -10.18 -0.49 2.26e-21 Pancreatic cancer; LUSC cis rs7659604 0.540 rs11724322 chr4:122697850 A/T cg06713675 chr4:122721982 EXOSC9 0.36 6.08 0.32 3.37e-9 Type 2 diabetes; LUSC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg08499158 chr17:42289980 UBTF -0.53 -8.52 -0.42 5.5e-16 Total body bone mineral density; LUSC cis rs727505 0.954 rs1525613 chr7:124658636 A/G cg23710748 chr7:124431027 NA -0.38 -6.58 -0.34 1.79e-10 Lewy body disease; LUSC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg19592336 chr6:28129416 ZNF389 0.54 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg18099408 chr3:52552593 STAB1 -0.42 -7.19 -0.37 4.39e-12 Bipolar disorder; LUSC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg01073479 chr16:3509474 NAT15 -0.45 -5.91 -0.31 8.41e-9 Tuberculosis; LUSC cis rs7614311 0.731 rs3774719 chr3:63950338 C/A cg22134162 chr3:63841271 THOC7 -0.49 -5.95 -0.31 6.73e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg13206674 chr6:150067644 NUP43 0.58 9.09 0.45 8.72e-18 Lung cancer; LUSC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.08 -0.32 3.23e-9 Platelet count; LUSC cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg08999081 chr20:33150536 PIGU 0.36 6.68 0.34 1.03e-10 Height; LUSC cis rs977987 0.806 rs4888411 chr16:75443183 T/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.61 -0.34 1.52e-10 Dupuytren's disease; LUSC cis rs4285028 0.747 rs9820511 chr3:121361345 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.72 -0.57 1.76e-30 Multiple sclerosis; LUSC cis rs11971779 0.680 rs10261557 chr7:139099037 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs478304 0.900 rs502468 chr11:65525119 T/G cg27068330 chr11:65405492 SIPA1 0.64 9.66 0.47 1.28e-19 Acne (severe); LUSC cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14442939 chr10:27389572 ANKRD26 -0.88 -9.9 -0.48 1.97e-20 Breast cancer; LUSC cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg08999081 chr20:33150536 PIGU 0.54 10.78 0.51 1.93e-23 Coronary artery disease; LUSC cis rs2625529 0.617 rs2128112 chr15:72186286 A/T cg16672083 chr15:72433130 SENP8 0.48 7.93 0.4 3.28e-14 Red blood cell count; LUSC cis rs7123876 0.587 rs184654 chr11:72364405 C/G cg03713592 chr11:72463424 ARAP1 0.63 7.3 0.37 2.07e-12 Body mass index; LUSC cis rs8032315 1.000 rs8032315 chr15:91418297 A/T cg04510874 chr15:91427884 FES 0.29 5.89 0.31 9.46e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg08859206 chr1:53392774 SCP2 -0.43 -6.95 -0.36 1.98e-11 Monocyte count; LUSC cis rs1003719 0.762 rs34273703 chr21:38475019 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.25 0.52 4.11e-25 Eye color traits; LUSC cis rs6582630 0.512 rs11181007 chr12:38266700 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.49 -0.42 6.96e-16 Drug-induced liver injury (flucloxacillin); LUSC trans rs2262909 0.962 rs73019889 chr19:22277826 C/G cg05197062 chr11:11642011 GALNTL4 0.54 7.58 0.38 3.39e-13 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs763121 0.888 rs2235229 chr22:39124912 A/G cg06022373 chr22:39101656 GTPBP1 0.67 10.56 0.5 1.13e-22 Menopause (age at onset); LUSC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs7000551 0.700 rs2469761 chr8:22367274 A/G cg12081754 chr8:22256438 SLC39A14 0.39 6.06 0.31 3.65e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs3764021 0.870 rs10466829 chr12:9876091 G/A cg20894963 chr12:9885564 CLECL1 0.35 7.11 0.36 7.09e-12 Type 1 diabetes; LUSC cis rs10078 0.571 rs2241597 chr5:480509 A/G cg08916839 chr5:415575 AHRR 0.75 7.14 0.36 6.01e-12 Fat distribution (HIV); LUSC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg12927641 chr6:109611667 NA -0.34 -5.77 -0.3 1.76e-8 Reticulocyte fraction of red cells; LUSC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg11366901 chr6:160182831 ACAT2 0.94 13.39 0.59 4.94e-33 Age-related macular degeneration (geographic atrophy); LUSC cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -8.7 -0.43 1.59e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4141404 0.851 rs5749222 chr22:31556759 C/G cg13145458 chr22:31556086 RNF185 0.44 5.72 0.3 2.37e-8 Paclitaxel-induced neuropathy; LUSC trans rs330071 0.686 rs10087406 chr8:9246598 C/T cg14343924 chr8:8086146 FLJ10661 -0.45 -6.32 -0.33 8.16e-10 Acne (severe); LUSC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg05623727 chr3:50126028 RBM5 0.35 6.56 0.34 2e-10 Body mass index; LUSC cis rs1595825 0.786 rs74652956 chr2:198754247 C/T cg10547527 chr2:198650123 BOLL -0.49 -5.71 -0.3 2.51e-8 Ulcerative colitis; LUSC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg25124228 chr12:125621409 AACS -0.48 -7.75 -0.39 1.15e-13 Post bronchodilator FEV1/FVC ratio; LUSC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg02534363 chr3:47050950 NBEAL2 -0.34 -5.65 -0.3 3.42e-8 Colorectal cancer; LUSC cis rs12681287 0.609 rs13281414 chr8:87495254 A/C cg27223183 chr8:87520930 FAM82B -0.55 -7.24 -0.37 3.19e-12 Caudate activity during reward; LUSC cis rs12824058 0.844 rs10744458 chr12:130805820 C/T cg23887609 chr12:130822674 PIWIL1 -0.43 -6.5 -0.34 2.85e-10 Menopause (age at onset); LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg22963979 chr7:1858916 MAD1L1 -0.64 -10.24 -0.49 1.4e-21 Bipolar disorder and schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03448938 chr2:209130777 PIKFYVE -0.41 -5.99 -0.31 5.41e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg10523860 chr14:103875565 MARK3 -0.38 -6.26 -0.32 1.15e-9 Body mass index; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05998816 chr21:47859926 PCNT 0.44 6.36 0.33 6.56e-10 Bipolar disorder and schizophrenia; LUSC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg18351406 chr4:77819688 ANKRD56 0.59 8.48 0.42 7.37e-16 Emphysema distribution in smoking; LUSC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg18681998 chr4:17616180 MED28 0.85 15.94 0.66 6.13e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs34734847 0.787 rs695948 chr12:121149596 A/G cg27246729 chr12:121163418 ACADS 0.42 6.62 0.34 1.4e-10 Mean corpuscular volume; LUSC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg10360139 chr7:1886902 MAD1L1 -0.43 -6.61 -0.34 1.54e-10 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg21535247 chr6:8435926 SLC35B3 0.57 8.9 0.44 3.51e-17 Motion sickness; LUSC trans rs61931739 0.534 rs12831685 chr12:34038392 C/T cg13010199 chr12:38710504 ALG10B 0.53 8.03 0.4 1.64e-14 Morning vs. evening chronotype; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg11267619 chr7:29604021 PRR15 -0.5 -6.23 -0.32 1.43e-9 Bipolar disorder and schizophrenia; LUSC cis rs425277 0.561 rs925906 chr1:2044054 A/C cg19257562 chr1:2043853 PRKCZ 0.3 5.98 0.31 5.61e-9 Height; LUSC cis rs2625529 0.938 rs2625530 chr15:72126034 G/A cg16672083 chr15:72433130 SENP8 -0.5 -7.11 -0.36 7.31e-12 Red blood cell count; LUSC cis rs929354 0.772 rs3802118 chr7:156986814 T/C cg05182265 chr7:156933206 UBE3C -0.59 -9.56 -0.46 2.61e-19 Body mass index; LUSC cis rs7216064 1.000 rs11869819 chr17:65868669 A/C cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg07424592 chr7:64974309 NA -0.63 -5.68 -0.3 2.9e-8 Diabetic kidney disease; LUSC cis rs231513 0.822 rs231520 chr17:41956983 T/C cg26893861 chr17:41843967 DUSP3 -0.5 -5.94 -0.31 7.03e-9 Cognitive function; LUSC trans rs2268344 0.630 rs2142309 chr10:124263692 T/C cg11199862 chr13:46108984 COG3 -0.68 -6.06 -0.31 3.75e-9 Coronary artery disease; LUSC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.98 -0.52 3.66e-24 Alzheimer's disease; LUSC cis rs17095355 1.000 rs9630102 chr10:111738662 A/T cg00817464 chr10:111662876 XPNPEP1 -0.57 -7.36 -0.37 1.43e-12 Biliary atresia; LUSC cis rs1577917 0.771 rs2842601 chr6:86330133 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.79 -0.43 8.06e-17 Response to antipsychotic treatment; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg01238044 chr22:24384105 GSTT1 -0.55 -8.01 -0.4 2e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg14552801 chr7:65878734 NA -0.37 -5.87 -0.31 1.08e-8 Aortic root size; LUSC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg22907277 chr7:1156413 C7orf50 0.67 7.43 0.38 8.98e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs469568 0.543 rs4700789 chr5:178669361 A/G cg08999896 chr5:178685787 ADAMTS2 0.39 7.67 0.39 1.86e-13 Stroke (pediatric); LUSC cis rs6076065 0.723 rs2424536 chr20:23381601 C/T cg11657817 chr20:23433608 CST11 0.43 8.24 0.41 4.07e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs6500395 1.000 rs9933187 chr16:48556573 A/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.53 -0.34 2.45e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6967385 0.519 rs7795828 chr7:12347689 C/T cg20607287 chr7:12443886 VWDE 0.53 7.87 0.4 5.08e-14 Response to taxane treatment (placlitaxel); LUSC cis rs7927592 0.913 rs11228276 chr11:68307525 A/G cg20283391 chr11:68216788 NA -0.61 -8.56 -0.42 4.24e-16 Total body bone mineral density; LUSC cis rs921968 0.565 rs35594672 chr2:219589280 T/A cg02176678 chr2:219576539 TTLL4 -0.58 -10.3 -0.49 8.75e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg14895029 chr7:2775587 GNA12 -0.44 -6.85 -0.35 3.65e-11 Height; LUSC trans rs561341 1.000 rs555629 chr17:30294136 T/C cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg05340658 chr4:99064831 C4orf37 0.66 10.97 0.51 4.2e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs11958404 0.932 rs72816584 chr5:157433190 G/A cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg07703079 chr11:430292 ANO9 0.6 6.52 0.34 2.66e-10 Body mass index; LUSC cis rs611744 0.583 rs1448148 chr8:109333074 T/A cg18478394 chr8:109455254 TTC35 0.44 6.8 0.35 4.76e-11 Dupuytren's disease; LUSC cis rs12908161 0.959 rs2175567 chr15:85200946 C/G cg17173187 chr15:85201210 NMB 0.47 8.99 0.44 1.84e-17 Schizophrenia; LUSC cis rs7572644 0.640 rs4666014 chr2:28019175 A/G cg27432699 chr2:27873401 GPN1 -0.56 -7.08 -0.36 8.62e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg24642439 chr20:33292090 TP53INP2 0.55 8.23 0.41 4.2e-15 Height; LUSC cis rs9503598 0.636 rs6596976 chr6:3466022 C/T cg00476032 chr6:3446245 SLC22A23 0.32 6.43 0.33 4.53e-10 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16726667 chr16:68002228 SLC12A4 -0.39 -5.95 -0.31 6.74e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg07194495 chr7:148958859 ZNF783 0.42 6.18 0.32 1.85e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1577917 1.000 rs1911553 chr6:86630892 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.33 -0.33 8.06e-10 Response to antipsychotic treatment; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg25703541 chr22:24373054 LOC391322 -0.9 -14.54 -0.62 1.92e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs561341 0.941 rs8066558 chr17:30272879 G/T cg27661571 chr11:113659931 NA -0.6 -7.18 -0.37 4.49e-12 Hip circumference adjusted for BMI; LUSC cis rs13315871 0.929 rs1045115 chr3:58305199 C/T cg12435725 chr3:58293450 RPP14 -0.62 -6.78 -0.35 5.45e-11 Cholesterol, total; LUSC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.19 0.37 4.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9653442 0.527 rs11690905 chr2:100761473 C/T cg07810366 chr2:100720526 AFF3 0.44 7.67 0.39 1.95e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs12579753 0.872 rs12319937 chr12:82182545 T/G cg07923666 chr12:49932857 KCNH3 -0.49 -6.09 -0.32 3.03e-9 Resting heart rate; LUSC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg07936489 chr17:37558343 FBXL20 0.72 10.06 0.48 5.9e-21 Glomerular filtration rate (creatinine); LUSC trans rs76248362 0.748 rs943061 chr13:24431968 C/T cg00599770 chr7:27196825 HOXA7 -0.64 -7.42 -0.38 9.91e-13 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs9443645 0.505 rs11752126 chr6:79707923 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.91 -0.31 8.46e-9 Intelligence (multi-trait analysis); LUSC cis rs10089 1.000 rs59484271 chr5:127503781 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 10.72 0.51 3.16e-23 Ileal carcinoids; LUSC cis rs11098499 0.909 rs28793658 chr4:120307214 A/C cg09307838 chr4:120376055 NA 0.77 11.23 0.52 4.66e-25 Corneal astigmatism; LUSC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg11843238 chr5:131593191 PDLIM4 0.34 5.84 0.3 1.23e-8 Breast cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg22331096 chr8:128749328 MYC -0.48 -6.25 -0.32 1.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs1577917 1.000 rs1857964 chr6:86635994 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs4595586 0.545 rs7136002 chr12:39369168 G/A cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7605827 0.897 rs7425203 chr2:15697410 A/G cg19274914 chr2:15703543 NA 0.47 9.04 0.44 1.32e-17 Educational attainment (years of education); LUSC cis rs6138458 0.626 rs6050259 chr20:25011423 A/G cg26195577 chr20:24973756 C20orf3 0.71 10.65 0.5 5.5e-23 Blood protein levels; LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg04632378 chr13:21900426 NA 0.32 5.99 0.31 5.45e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg25039879 chr17:56429692 SUPT4H1 0.67 8.85 0.44 5.03e-17 Cognitive test performance; LUSC cis rs2677744 0.626 rs3743452 chr15:91497515 C/T cg01368872 chr15:91498139 RCCD1 -0.43 -5.69 -0.3 2.76e-8 Attention deficit hyperactivity disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23966157 chr14:74486355 C14orf45;ENTPD5 -0.42 -6.08 -0.32 3.36e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs79976124 0.797 rs78317899 chr6:66652896 C/A cg07460842 chr6:66804631 NA 0.73 9.09 0.45 9.29e-18 Type 2 diabetes; LUSC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg27432699 chr2:27873401 GPN1 -0.58 -8.68 -0.43 1.72e-16 Total body bone mineral density; LUSC cis rs1865760 0.713 rs6928951 chr6:25995554 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 7.0 0.36 1.44e-11 Height; LUSC trans rs975739 0.868 rs5351 chr13:78475313 C/T cg00971891 chr3:88199395 C3orf38 -0.35 -5.98 -0.31 5.7e-9 Hair color; LUSC cis rs7618501 0.933 rs3811695 chr3:49761613 C/T cg07274523 chr3:49395745 GPX1 0.36 5.76 0.3 1.93e-8 Intelligence (multi-trait analysis); LUSC cis rs11112613 0.713 rs17037317 chr12:105952058 T/C cg03607813 chr12:105948248 NA 0.78 11.89 0.55 1.96e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg25072359 chr17:41440525 NA 0.66 9.4 0.46 8.95e-19 Menopause (age at onset); LUSC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.26 -0.32 1.17e-9 Life satisfaction; LUSC cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg08923669 chr16:420230 MRPL28 -0.43 -7.32 -0.37 1.91e-12 Bone mineral density (spine);Bone mineral density; LUSC cis rs2806561 0.765 rs1997866 chr1:23512524 A/G cg12483005 chr1:23474871 LUZP1 0.43 6.69 0.34 9.54e-11 Height; LUSC cis rs6062509 0.895 rs6011040 chr20:62337406 C/T cg05643964 chr20:62369504 LIME1 0.39 5.95 0.31 6.65e-9 Prostate cancer; LUSC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg08677398 chr8:58056175 NA 0.54 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); LUSC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg25258033 chr6:167368657 RNASET2 0.45 7.15 0.36 5.55e-12 Crohn's disease; LUSC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs4595586 0.566 rs7135104 chr12:39411086 C/T cg26384229 chr12:38710491 ALG10B 0.46 6.53 0.34 2.39e-10 Morning vs. evening chronotype; LUSC cis rs4073582 0.595 rs708472 chr11:65930990 A/G cg16950941 chr11:66035639 RAB1B 0.49 7.13 0.36 6.41e-12 Gout; LUSC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg24060327 chr5:131705240 SLC22A5 -0.39 -6.48 -0.33 3.38e-10 Blood metabolite levels; LUSC cis rs1997103 1.000 rs6958022 chr7:55397389 G/A cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9902453 0.765 rs2467334 chr17:28135508 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -11.67 -0.54 1.29e-26 Coffee consumption (cups per day); LUSC cis rs96067 0.711 rs795047 chr1:36637708 C/T cg24686825 chr1:36642396 MAP7D1 0.52 7.97 0.4 2.48e-14 Corneal structure; LUSC cis rs1595825 0.891 rs73058864 chr2:198889587 C/T cg10547527 chr2:198650123 BOLL -0.52 -6.3 -0.33 9.56e-10 Ulcerative colitis; LUSC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg12963246 chr6:28129442 ZNF389 0.58 8.07 0.4 1.24e-14 Parkinson's disease; LUSC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.62 -0.34 1.39e-10 High light scatter reticulocyte count; LUSC cis rs1044826 0.913 rs9825064 chr3:139049804 C/T cg00490450 chr3:139108681 COPB2 0.55 7.29 0.37 2.32e-12 Obesity-related traits; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg23131131 chr22:24373011 LOC391322 -0.42 -6.12 -0.32 2.6e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7100689 0.784 rs3802637 chr10:82179699 G/C cg01528321 chr10:82214614 TSPAN14 1.13 18.28 0.71 3.23e-52 Post bronchodilator FEV1; LUSC cis rs9611565 0.921 rs8137373 chr22:41729216 A/G cg03806693 chr22:41940476 POLR3H 0.79 11.91 0.55 1.74e-27 Vitiligo; LUSC cis rs12908161 0.920 rs35738019 chr15:85280210 T/C cg12863693 chr15:85201151 NMB 0.41 8.58 0.42 3.65e-16 Schizophrenia; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26397265 chr12:25348258 LYRM5;CASC1 0.38 6.14 0.32 2.35e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4660306 1.000 rs882803 chr1:45976147 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.43 -6.87 -0.35 3.2e-11 Homocysteine levels; LUSC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg15704280 chr7:45808275 SEPT13 -1.01 -18.93 -0.72 8.57e-55 Height; LUSC cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg00677455 chr12:58241039 CTDSP2 -0.47 -7.03 -0.36 1.14e-11 Intelligence (multi-trait analysis); LUSC cis rs10779751 0.770 rs2275527 chr1:11190646 A/G cg08854313 chr1:11322531 MTOR 0.72 10.85 0.51 1.06e-23 Body mass index; LUSC cis rs61931739 0.513 rs7956626 chr12:33901640 C/T cg06521331 chr12:34319734 NA -0.37 -6.05 -0.31 3.81e-9 Morning vs. evening chronotype; LUSC cis rs314370 0.855 rs76181418 chr7:100494960 G/T cg18683606 chr7:100471612 SRRT 0.46 6.12 0.32 2.56e-9 Resting heart rate; LUSC trans rs61931739 1.000 rs12427279 chr12:34025898 T/G cg26384229 chr12:38710491 ALG10B -0.51 -7.76 -0.39 1.07e-13 Morning vs. evening chronotype; LUSC cis rs1065656 0.619 rs2492883 chr16:1902105 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.44 -6.39 -0.33 5.48e-10 Insulin-like growth factors; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07080756 chr10:104192239 CUEDC2 -0.46 -6.74 -0.35 6.91e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9905704 0.718 rs72826360 chr17:56664395 T/G cg12560992 chr17:57184187 TRIM37 0.51 5.96 0.31 6.45e-9 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg23788917 chr6:8435910 SLC35B3 0.51 7.69 0.39 1.63e-13 Motion sickness; LUSC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.54 -8.04 -0.4 1.53e-14 Gut microbiome composition (summer); LUSC cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.38 5.65 0.3 3.51e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg15369054 chr17:80825471 TBCD -0.66 -10.81 -0.51 1.44e-23 Breast cancer; LUSC cis rs240764 0.658 rs9386257 chr6:101252069 A/T cg09795085 chr6:101329169 ASCC3 0.45 6.5 0.34 2.9e-10 Neuroticism; LUSC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg21724239 chr8:58056113 NA 0.56 6.69 0.34 9.55e-11 Developmental language disorder (linguistic errors); LUSC cis rs9303542 0.625 rs11868098 chr17:46570869 C/G cg09704116 chr17:46666958 LOC404266 0.32 5.9 0.31 8.99e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC trans rs6089829 0.962 rs2277768 chr20:61666823 T/C cg17470723 chr8:74884337 TCEB1 0.53 8.26 0.41 3.42e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg04414720 chr1:150670196 GOLPH3L 0.49 7.88 0.4 4.66e-14 Melanoma; LUSC cis rs6960043 1.000 rs62448644 chr7:15053485 C/T cg19272540 chr7:15055459 NA -0.3 -7.22 -0.37 3.56e-12 Type 2 diabetes; LUSC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg11764359 chr7:65958608 NA -0.7 -10.8 -0.51 1.57e-23 Aortic root size; LUSC cis rs4654899 0.802 rs17449966 chr1:21203996 A/G cg02927042 chr1:21476669 EIF4G3 -0.38 -5.99 -0.31 5.4e-9 Superior frontal gyrus grey matter volume; LUSC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg27297192 chr10:134578999 INPP5A 0.37 6.03 0.31 4.24e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg02609749 chr16:89786786 C16orf7;ZNF276 -0.37 -5.94 -0.31 7.36e-9 Vitiligo; LUSC cis rs6722750 0.651 rs12987393 chr2:64421514 C/T cg22352474 chr2:64371530 PELI1 0.53 7.95 0.4 2.95e-14 Neuroticism; LUSC cis rs7772486 0.875 rs7739418 chr6:146359188 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.2 -0.37 4.06e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg08493051 chr2:3487164 NA -0.57 -8.84 -0.44 5.51e-17 Neurofibrillary tangles; LUSC cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg02527881 chr3:46936655 PTH1R -0.39 -6.76 -0.35 6.22e-11 Colorectal cancer; LUSC trans rs7746199 0.668 rs7749305 chr6:27446566 T/C cg06606381 chr12:133084897 FBRSL1 -0.81 -7.93 -0.4 3.24e-14 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs3806843 0.900 rs2563287 chr5:140124786 C/T cg26395211 chr5:140044315 WDR55 -0.38 -6.04 -0.31 4.21e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs4356932 1.000 rs4241578 chr4:76944491 T/C cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs55871839 0.708 rs4738730 chr8:59808935 A/T cg07426533 chr8:59803705 TOX -0.37 -6.01 -0.31 4.92e-9 Pneumonia; LUSC cis rs259282 0.524 rs3760941 chr19:33130866 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.81 12.19 0.55 1.56e-28 Schizophrenia; LUSC cis rs8141529 0.764 rs5752809 chr22:29225500 G/A cg15103426 chr22:29168792 CCDC117 0.59 8.3 0.41 2.69e-15 Lymphocyte counts; LUSC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg05855489 chr10:104503620 C10orf26 0.6 9.61 0.47 1.88e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg20684491 chr1:25596433 NA 0.4 6.34 0.33 7.43e-10 Erythrocyte sedimentation rate; LUSC cis rs4975709 0.569 rs2353583 chr5:1858834 G/C cg15595755 chr5:1867978 NA 0.46 8.13 0.41 8.32e-15 Cardiovascular disease risk factors; LUSC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg21573476 chr21:45109991 RRP1B -0.38 -6.08 -0.32 3.2e-9 Mean corpuscular volume; LUSC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg02423579 chr7:2872169 GNA12 -0.47 -7.06 -0.36 9.81e-12 Height; LUSC trans rs2243480 1.000 rs316313 chr7:65593548 G/A cg10756647 chr7:56101905 PSPH 0.83 8.37 0.42 1.66e-15 Diabetic kidney disease; LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.85e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs62103177 0.810 rs62103197 chr18:77632923 G/A cg05926928 chr17:57297772 GDPD1 1.53 17.07 0.68 1.97e-47 Opioid sensitivity; LUSC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.45 0.33 3.85e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg12292205 chr6:26970375 C6orf41 -0.58 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg18765753 chr7:1198926 ZFAND2A -0.44 -7.53 -0.38 4.89e-13 Longevity;Endometriosis; LUSC trans rs7824557 0.628 rs7841394 chr8:11185671 G/T cg15556689 chr8:8085844 FLJ10661 0.42 6.26 0.32 1.17e-9 Retinal vascular caliber; LUSC cis rs576982 1 rs576982 chr15:78870803 C/T cg06917634 chr15:78832804 PSMA4 -0.53 -6.59 -0.34 1.69e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7216064 1.000 rs12452511 chr17:65832576 A/G cg12091567 chr17:66097778 LOC651250 -0.73 -8.81 -0.43 7.2e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7264396 0.790 rs6060565 chr20:34285442 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.54 -0.46 3e-19 Total cholesterol levels; LUSC cis rs8017423 0.967 rs7155315 chr14:90700787 G/A cg04374321 chr14:90722782 PSMC1 0.73 11.56 0.53 3.11e-26 Mortality in heart failure; LUSC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs501916 0.833 rs11629796 chr15:48045248 A/G cg16110827 chr15:48056943 SEMA6D -0.42 -6.54 -0.34 2.32e-10 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7973719 0.966 rs7310539 chr12:7329996 C/G cg07052231 chr12:7363540 PEX5 0.53 9.06 0.44 1.1e-17 IgG glycosylation; LUSC cis rs9341808 0.905 rs3805903 chr6:80975829 T/C cg08355045 chr6:80787529 NA 0.51 9.06 0.44 1.13e-17 Sitting height ratio; LUSC cis rs2637266 0.745 rs241 chr10:78444456 G/T cg18941641 chr10:78392320 NA 0.32 5.8 0.3 1.58e-8 Pulmonary function; LUSC cis rs4474465 1.000 rs10793313 chr11:78169310 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.66 -0.3 3.32e-8 Alzheimer's disease (survival time); LUSC cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg09479241 chr17:27052676 TLCD1 0.44 5.9 0.31 8.93e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9311676 0.632 rs62259779 chr3:58425692 C/G cg13750441 chr3:58318267 PXK 0.35 6.73 0.35 7.53e-11 Systemic lupus erythematosus; LUSC cis rs6977660 0.660 rs10253753 chr7:19823032 A/G cg05791153 chr7:19748676 TWISTNB 0.64 6.74 0.35 6.97e-11 Thyroid stimulating hormone; LUSC cis rs4474465 0.850 rs7111004 chr11:78269961 G/A cg27205649 chr11:78285834 NARS2 0.52 6.19 0.32 1.8e-9 Alzheimer's disease (survival time); LUSC trans rs7615952 0.673 rs9289270 chr3:125636979 A/T cg07211511 chr3:129823064 LOC729375 -1.05 -12.96 -0.58 2.17e-31 Blood pressure (smoking interaction); LUSC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.21 -0.37 3.84e-12 Major depressive disorder; LUSC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 14.51 0.62 2.55e-37 Platelet count; LUSC cis rs240764 0.658 rs9498390 chr6:101241438 T/A cg09795085 chr6:101329169 ASCC3 -0.45 -6.46 -0.33 3.75e-10 Neuroticism; LUSC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4595586 0.545 rs12819061 chr12:39386976 C/T cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg23711669 chr6:146136114 FBXO30 -0.91 -17.26 -0.69 3.56e-48 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05095774 chr18:52495848 RAB27B 0.42 6.32 0.33 8.23e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2324229 0.828 rs1180228 chr6:83950566 G/A cg08257003 chr6:84140564 ME1 0.28 6.78 0.35 5.51e-11 Platelet-derived growth factor BB levels; LUSC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg05313129 chr8:58192883 C8orf71 -0.55 -6.1 -0.32 2.9e-9 Developmental language disorder (linguistic errors); LUSC cis rs3125734 0.633 rs4979782 chr10:63998527 C/T cg19640130 chr10:64028056 RTKN2 -0.4 -7.15 -0.36 5.41e-12 Rheumatoid arthritis; LUSC cis rs12200560 0.505 rs211167 chr6:97069087 T/A cg06623918 chr6:96969491 KIAA0776 0.49 7.02 0.36 1.26e-11 Coronary heart disease; LUSC cis rs1997103 0.911 rs11238361 chr7:55395981 A/G cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7590368 0.715 rs7571007 chr2:10961297 C/T cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs10865541 0.902 rs12474836 chr2:3418874 A/G cg15807143 chr2:3452624 TTC15 0.32 5.67 0.3 3.09e-8 Obesity-related traits; LUSC cis rs9326248 0.581 rs11216267 chr11:116952392 C/T cg20608306 chr11:116969690 SIK3 0.36 6.83 0.35 4.09e-11 Blood protein levels; LUSC cis rs9361491 0.657 rs9361426 chr6:79457550 G/T cg05283184 chr6:79620031 NA -0.32 -5.81 -0.3 1.43e-8 Intelligence (multi-trait analysis); LUSC cis rs2230307 0.536 rs6577152 chr1:100434610 A/G cg24955406 chr1:100503596 HIAT1 0.56 6.04 0.31 4.01e-9 Carotid intima media thickness; LUSC cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg05890377 chr2:74357713 NA 0.72 13.81 0.6 1.25e-34 Gestational age at birth (maternal effect); LUSC cis rs68092024 0.731 rs793480 chr3:99488364 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -6.14 -0.32 2.31e-9 Cleft lip with or without cleft palate; LUSC cis rs3087591 0.887 rs12150521 chr17:29595108 C/T cg24425628 chr17:29625626 OMG;NF1 0.58 8.31 0.41 2.41e-15 Hip circumference; LUSC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg17971929 chr21:40555470 PSMG1 0.66 10.98 0.52 3.72e-24 Cognitive function; LUSC cis rs4363385 0.588 rs12079087 chr1:153023888 T/C cg00922841 chr1:152955080 SPRR1A -0.36 -5.95 -0.31 6.82e-9 Inflammatory skin disease; LUSC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg02018176 chr4:1364513 KIAA1530 0.39 6.69 0.34 9.25e-11 Obesity-related traits; LUSC cis rs11971779 0.680 rs7783619 chr7:139061437 G/A cg07862535 chr7:139043722 LUC7L2 0.55 6.87 0.35 3.08e-11 Diisocyanate-induced asthma; LUSC cis rs7267979 0.933 rs1130694 chr20:25276297 G/A cg03522245 chr20:25566470 NINL 0.35 5.7 0.3 2.57e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs17780086 0.527 rs72827711 chr17:30537920 T/A cg27661571 chr11:113659931 NA -0.64 -5.99 -0.31 5.43e-9 Height; LUSC cis rs73198271 0.515 rs77703937 chr8:8629129 G/A cg01851573 chr8:8652454 MFHAS1 0.61 7.01 0.36 1.34e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs926938 0.520 rs2007231 chr1:115266306 C/T cg12756093 chr1:115239321 AMPD1 -0.56 -8.12 -0.41 9.04e-15 Autism; LUSC cis rs7904368 0.806 rs7900527 chr10:16857992 C/G cg23933602 chr10:16859644 RSU1 0.5 6.01 0.31 4.84e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg21724239 chr8:58056113 NA 0.59 7.09 0.36 8.15e-12 Developmental language disorder (linguistic errors); LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg18538332 chr22:24372958 LOC391322 -0.37 -6.69 -0.34 9.68e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg13119609 chr19:45449297 APOC2 0.47 9.7 0.47 9.53e-20 Blood protein levels; LUSC cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.09 16.34 0.67 1.65e-44 Gut microbiome composition (summer); LUSC cis rs4243830 0.850 rs2412309 chr1:6603151 A/G cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.03 -0.31 4.3e-9 Body mass index; LUSC cis rs1595825 0.891 rs75946628 chr2:198546239 C/T cg00982548 chr2:198649783 BOLL -0.54 -6.86 -0.35 3.4e-11 Ulcerative colitis; LUSC cis rs3774749 0.565 rs2188151 chr3:50201924 A/C cg14019146 chr3:50243930 SLC38A3 0.45 10.72 0.51 3.06e-23 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg26597838 chr10:835615 NA 0.99 13.4 0.59 4.76e-33 Eosinophil percentage of granulocytes; LUSC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.94 -0.44 2.66e-17 Breast cancer; LUSC cis rs9420 0.961 rs11229131 chr11:57562525 G/A cg23127183 chr11:57508653 C11orf31 -0.57 -8.81 -0.43 6.86e-17 Schizophrenia; LUSC cis rs644799 0.509 rs580181 chr11:95643040 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.59 8.62 0.43 2.77e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs67478160 0.608 rs11628787 chr14:104323984 G/A cg01849466 chr14:104193079 ZFYVE21 0.6 9.93 0.48 1.52e-20 Schizophrenia; LUSC cis rs61931739 0.500 rs11053211 chr12:34464334 T/C cg06521331 chr12:34319734 NA -0.42 -6.91 -0.35 2.41e-11 Morning vs. evening chronotype; LUSC trans rs911555 0.755 rs8018400 chr14:103901085 A/G cg17675199 chr6:35436792 RPL10A -0.41 -5.98 -0.31 5.73e-9 Intelligence (multi-trait analysis); LUSC cis rs477692 0.967 rs488143 chr10:131407369 A/C cg05714579 chr10:131428358 MGMT 0.53 8.03 0.4 1.74e-14 Response to temozolomide; LUSC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg26380479 chr7:97908229 NA -0.26 -5.81 -0.3 1.43e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs1127311 1.000 rs10908419 chr1:154567699 G/A cg17218026 chr1:154582156 ADAR 0.57 10.15 0.49 2.89e-21 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6964587 0.869 rs10242792 chr7:91492103 A/C cg17063962 chr7:91808500 NA 0.5 7.71 0.39 1.46e-13 Breast cancer; LUSC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg24289452 chr6:170231220 NA -0.39 -6.7 -0.34 8.96e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg04414720 chr1:150670196 GOLPH3L 0.5 7.67 0.39 1.86e-13 Melanoma; LUSC cis rs7819412 0.521 rs2409720 chr8:11037903 A/C cg21775007 chr8:11205619 TDH -0.49 -6.99 -0.36 1.53e-11 Triglycerides; LUSC cis rs9325144 0.647 rs12830095 chr12:38864199 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.45 -0.38 8.18e-13 Morning vs. evening chronotype; LUSC cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg04362960 chr10:104952993 NT5C2 0.57 8.31 0.41 2.36e-15 Arsenic metabolism; LUSC cis rs34779708 0.771 rs12098283 chr10:35478115 G/T cg03585969 chr10:35415529 CREM 0.61 8.99 0.44 1.93e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11676348 0.818 rs6436031 chr2:218979259 T/C cg06547715 chr2:218990976 CXCR2 0.33 6.38 0.33 5.81e-10 Ulcerative colitis; LUSC cis rs17818399 0.510 rs12105801 chr2:46799343 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.05 -0.36 1.01e-11 Height; LUSC cis rs478304 0.654 rs7934036 chr11:65451020 G/T cg27068330 chr11:65405492 SIPA1 -0.73 -10.14 -0.49 3.13e-21 Acne (severe); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03062665 chr14:90863127 CALM1 -0.4 -6.01 -0.31 4.91e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.89 12.61 0.57 4.5e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs983392 0.679 rs7121656 chr11:60024008 C/T cg02771260 chr11:59836817 MS4A3 0.38 6.21 0.32 1.53e-9 Alzheimer's disease (late onset); LUSC cis rs72772090 0.539 rs11135480 chr5:96110582 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.74 -7.49 -0.38 6.25e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7927771 0.542 rs7122217 chr11:47777920 G/C cg20307385 chr11:47447363 PSMC3 -0.44 -6.61 -0.34 1.51e-10 Subjective well-being; LUSC cis rs9300255 0.544 rs1790123 chr12:123659542 C/T cg00376283 chr12:123451042 ABCB9 0.71 7.93 0.4 3.43e-14 Neutrophil percentage of white cells; LUSC trans rs12439619 0.508 rs8042665 chr15:82481349 A/T cg04831495 chr15:85060580 GOLGA6L5 -0.49 -7.87 -0.4 4.93e-14 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg11494091 chr17:61959527 GH2 0.66 14.13 0.61 7.05e-36 Prudent dietary pattern; LUSC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg12564285 chr5:131593104 PDLIM4 0.38 7.04 0.36 1.13e-11 Blood metabolite levels; LUSC cis rs11190604 1.000 rs11190601 chr10:102296730 A/G cg07080220 chr10:102295463 HIF1AN 0.69 9.27 0.45 2.43e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg03538708 chr1:25844672 NA -0.37 -6.08 -0.32 3.22e-9 Erythrocyte sedimentation rate; LUSC cis rs6459788 0.934 rs10251462 chr7:157258183 C/G cg06271696 chr7:157225062 NA -0.37 -6.81 -0.35 4.58e-11 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs2191566 0.761 rs446016 chr19:44501518 A/G cg18700516 chr19:44507157 ZNF230 -0.45 -5.96 -0.31 6.47e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs453301 0.597 rs7001187 chr8:8792782 G/A cg08975724 chr8:8085496 FLJ10661 -0.42 -5.99 -0.31 5.29e-9 Joint mobility (Beighton score); LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg06873352 chr17:61820015 STRADA 0.71 12.78 0.57 9.99e-31 Prudent dietary pattern; LUSC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg21211367 chr2:162094118 NA 0.44 7.13 0.36 6.31e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs4964805 0.865 rs4964780 chr12:104206859 A/G cg02344784 chr12:104178138 NT5DC3 0.44 6.83 0.35 4.09e-11 Attention deficit hyperactivity disorder; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg17178900 chr1:205818956 PM20D1 0.8 13.42 0.59 3.9e-33 Menarche (age at onset); LUSC cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg23649088 chr2:200775458 C2orf69 -0.5 -6.77 -0.35 5.92e-11 Schizophrenia; LUSC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg16325326 chr1:53192061 ZYG11B 0.86 15.95 0.66 5.42e-43 Monocyte count; LUSC cis rs7267979 1.000 rs3761117 chr20:25388070 G/A cg03522245 chr20:25566470 NINL -0.35 -5.65 -0.3 3.45e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11098499 0.743 rs11098501 chr4:120252017 T/G cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs12681288 0.550 rs12674921 chr8:957969 A/C cg04851639 chr8:1020857 NA -0.35 -6.97 -0.36 1.67e-11 Schizophrenia; LUSC cis rs9486715 0.830 rs2255552 chr6:96999643 A/G cg06623918 chr6:96969491 KIAA0776 -0.93 -17.45 -0.69 6.07e-49 Headache; LUSC cis rs4711350 0.734 rs7739273 chr6:33758065 G/A cg18005901 chr6:33739558 LEMD2 -0.39 -5.74 -0.3 2.07e-8 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23589045 chr1:51983759 EPS15 -0.41 -6.09 -0.32 3.12e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg23791538 chr6:167370224 RNASET2 0.41 6.52 0.34 2.59e-10 Crohn's disease; LUSC cis rs478304 0.654 rs10896032 chr11:65459419 C/A cg05805236 chr11:65401703 PCNXL3 -0.65 -10.61 -0.5 7.57e-23 Acne (severe); LUSC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg20243544 chr17:37824526 PNMT -0.46 -6.55 -0.34 2.18e-10 Asthma; LUSC trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.51 -7.09 -0.36 8.23e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs8017423 0.935 rs3783838 chr14:90733012 A/G cg04374321 chr14:90722782 PSMC1 -0.67 -10.27 -0.49 1.08e-21 Mortality in heart failure; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg23849483 chr19:15224544 SYDE1 -0.39 -5.95 -0.31 6.64e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4654899 0.680 rs10916885 chr1:21188703 A/T cg01072550 chr1:21505969 NA 0.48 7.39 0.37 1.21e-12 Superior frontal gyrus grey matter volume; LUSC cis rs11105298 0.891 rs10858865 chr12:89846476 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.3 -0.37 2.06e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg03433033 chr1:76189801 ACADM -0.72 -9.63 -0.47 1.61e-19 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.27 0.45 2.3e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg12432903 chr7:1882776 MAD1L1 -0.36 -5.8 -0.3 1.51e-8 Bipolar disorder and schizophrenia; LUSC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg27124370 chr19:33622961 WDR88 -0.59 -8.01 -0.4 1.95e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 14.06 0.61 1.38e-35 Platelet count; LUSC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg00033643 chr7:134001901 SLC35B4 0.46 7.15 0.36 5.64e-12 Mean platelet volume; LUSC cis rs1371867 0.875 rs962452 chr8:101331369 G/A cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.37e-11 Atrioventricular conduction; LUSC cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.35 -5.79 -0.3 1.6e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7208859 0.623 rs28556733 chr17:29083945 T/G cg13385521 chr17:29058706 SUZ12P 0.71 7.05 0.36 1.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6429082 0.689 rs10925965 chr1:235708443 C/A cg26050004 chr1:235667680 B3GALNT2 -0.47 -6.25 -0.32 1.29e-9 Adiposity; LUSC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg09085632 chr11:111637200 PPP2R1B -1.05 -17.16 -0.68 8.97e-48 Primary sclerosing cholangitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg27425452 chr6:163148853 PARK2;PACRG -0.42 -6.18 -0.32 1.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1949733 1.000 rs1357481 chr4:8496221 A/T cg11789530 chr4:8429930 ACOX3 0.63 9.73 0.47 7.29e-20 Response to antineoplastic agents; LUSC cis rs1908814 0.516 rs60176945 chr8:11796674 T/C cg21775007 chr8:11205619 TDH 0.46 6.4 0.33 5.19e-10 Neuroticism; LUSC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.07e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs3127573 1.000 rs3119309 chr6:160685072 A/G cg25150520 chr1:3142530 PRDM16 -0.42 -5.96 -0.31 6.25e-9 Creatinine levels; LUSC trans rs7824557 0.564 rs2572392 chr8:11235605 T/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.53 -0.38 4.91e-13 Retinal vascular caliber; LUSC cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg22117172 chr7:91764530 CYP51A1 0.32 5.84 0.3 1.21e-8 Breast cancer; LUSC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs11190604 1.000 rs4244338 chr10:102272802 A/G cg07080220 chr10:102295463 HIF1AN 0.69 9.37 0.46 1.09e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg18252515 chr7:66147081 NA 1.13 13.19 0.59 2.98e-32 Diabetic kidney disease; LUSC cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg22508957 chr16:3507546 NAT15 0.44 6.41 0.33 5.08e-10 Body mass index (adult); LUSC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg19318889 chr4:1322082 MAEA 0.48 7.92 0.4 3.46e-14 Obesity-related traits; LUSC cis rs7681440 0.904 rs28415623 chr4:90767110 C/T cg01966878 chr4:90757139 SNCA -0.35 -6.12 -0.32 2.56e-9 Dementia with Lewy bodies; LUSC cis rs4478858 0.735 rs10914361 chr1:31817542 T/G cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg04166393 chr7:2884313 GNA12 0.44 6.06 0.31 3.7e-9 Height; LUSC cis rs7771547 0.607 rs632943 chr6:36469121 A/G cg07856975 chr6:36356162 ETV7 0.38 6.65 0.34 1.2e-10 Platelet distribution width; LUSC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg16405210 chr4:1374714 KIAA1530 -0.57 -8.8 -0.43 7.35e-17 Obesity-related traits; LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.66 0.63 6.18e-38 Platelet count; LUSC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg02551604 chr5:131831745 NA -0.42 -6.62 -0.34 1.39e-10 Asthma (sex interaction); LUSC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18099408 chr3:52552593 STAB1 -0.41 -7.2 -0.37 3.9e-12 Bipolar disorder; LUSC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg20243544 chr17:37824526 PNMT 0.39 5.85 0.3 1.19e-8 Self-reported allergy; LUSC trans rs12310956 0.510 rs4931759 chr12:33871969 T/C cg13010199 chr12:38710504 ALG10B 0.43 6.67 0.34 1.07e-10 Morning vs. evening chronotype; LUSC cis rs4268898 1.000 rs6746005 chr2:24434345 G/A cg06627628 chr2:24431161 ITSN2 0.63 9.41 0.46 8.56e-19 Asthma; LUSC trans rs17780086 0.527 rs17182651 chr17:30547537 G/A cg20587970 chr11:113659929 NA -1.18 -12.16 -0.55 1.97e-28 Height; LUSC cis rs4704187 0.687 rs6879894 chr5:74498164 C/A cg03227963 chr5:74354835 NA 0.3 6.64 0.34 1.24e-10 Response to amphetamines; LUSC cis rs61990749 0.597 rs1006039 chr14:78263196 C/T cg23188588 chr14:78226832 SNW1;C14orf178 -0.52 -5.77 -0.3 1.81e-8 Fibroblast growth factor basic levels; LUSC cis rs6681460 0.546 rs12117649 chr1:67168606 G/A cg02459107 chr1:67143332 SGIP1 0.34 5.98 0.31 5.75e-9 Presence of antiphospholipid antibodies; LUSC cis rs13256369 0.802 rs34762800 chr8:8559294 G/A cg06671706 chr8:8559999 CLDN23 0.5 6.49 0.33 3.11e-10 Obesity-related traits; LUSC cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg14582100 chr15:45693742 SPATA5L1 0.5 8.26 0.41 3.35e-15 Homoarginine levels; LUSC cis rs1843834 1.000 rs1565072 chr2:225545245 C/T cg22455342 chr2:225449267 CUL3 -0.46 -6.35 -0.33 7.17e-10 IgE levels in asthmatics (D.p. specific); LUSC cis rs3736594 0.649 rs867282 chr2:27951658 A/G cg27432699 chr2:27873401 GPN1 -0.62 -9.13 -0.45 6.81e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs35995292 1.000 rs56098802 chr7:38913730 T/C cg19327137 chr7:38886074 VPS41 0.34 5.67 0.3 3.1e-8 Subjective well-being (multi-trait analysis); LUSC cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg06454157 chr6:167490870 NA -0.24 -6.04 -0.31 4.19e-9 Crohn's disease; LUSC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg05425664 chr17:57184151 TRIM37 0.58 8.94 0.44 2.63e-17 Intelligence (multi-trait analysis); LUSC cis rs12618769 0.597 rs1961651 chr2:99049674 G/C cg10123293 chr2:99228465 UNC50 0.47 7.94 0.4 3.19e-14 Bipolar disorder; LUSC cis rs12575480 0.637 rs73398080 chr11:2094599 G/A cg15541987 chr11:2077307 NA -0.45 -6.82 -0.35 4.22e-11 Pursuit maintenance gain; LUSC cis rs4851254 0.660 rs35869550 chr2:100684578 T/A cg07810366 chr2:100720526 AFF3 -0.47 -6.19 -0.32 1.81e-9 Intelligence (multi-trait analysis); LUSC cis rs4478858 0.735 rs34960310 chr1:31816197 A/G cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs7129556 0.520 rs4945185 chr11:77318142 G/A cg12586386 chr11:77299805 AQP11 0.22 5.64 0.3 3.56e-8 Weight loss (gastric bypass surgery); LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg10360139 chr7:1886902 MAD1L1 -0.4 -6.05 -0.31 3.82e-9 Bipolar disorder and schizophrenia; LUSC cis rs8017423 0.522 rs12887028 chr14:90819605 A/G cg04374321 chr14:90722782 PSMC1 -0.44 -6.63 -0.34 1.34e-10 Mortality in heart failure; LUSC cis rs9905704 0.633 rs2632511 chr17:56490989 G/A cg12560992 chr17:57184187 TRIM37 0.49 5.8 0.3 1.51e-8 Testicular germ cell tumor; LUSC cis rs2014572 0.967 rs10412975 chr19:57770554 C/A cg24459738 chr19:57751996 ZNF805 -0.51 -7.54 -0.38 4.6e-13 Hyperactive-impulsive symptoms; LUSC cis rs3820068 0.705 rs4646092 chr1:15821673 C/T cg17385448 chr1:15911702 AGMAT 0.37 5.86 0.31 1.08e-8 Systolic blood pressure; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg23034840 chr1:205782522 SLC41A1 0.67 9.98 0.48 1.04e-20 Menarche (age at onset); LUSC cis rs829883 0.664 rs829864 chr12:98850195 C/T cg25150519 chr12:98850993 NA 0.83 14.13 0.61 7.1e-36 Colorectal adenoma (advanced); LUSC cis rs10779751 0.734 rs1034528 chr1:11249132 G/C cg08854313 chr1:11322531 MTOR -0.86 -13.56 -0.6 1.08e-33 Body mass index; LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg12419862 chr22:24373484 LOC391322 -0.95 -18.21 -0.71 6.25e-52 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10170310 1.000 rs6720716 chr2:139268802 A/G cg03782584 chr2:139258740 SPOPL 0.33 5.86 0.31 1.12e-8 Response to antipsychotic treatment; LUSC cis rs35123781 1.000 rs673632 chr5:139057237 G/T cg10513866 chr5:139070639 NA 0.46 8.88 0.44 4.25e-17 Schizophrenia; LUSC cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg16386425 chr10:429943 DIP2C 0.39 5.78 0.3 1.69e-8 Psychosis in Alzheimer's disease; LUSC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg00579200 chr11:133705235 NA -0.39 -5.7 -0.3 2.58e-8 Childhood ear infection; LUSC cis rs9875589 0.509 rs1873005 chr3:14060223 G/A cg19554555 chr3:13937349 NA -0.38 -5.72 -0.3 2.32e-8 Ovarian reserve; LUSC cis rs1153858 1.000 rs1719247 chr15:45620985 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.12 0.41 9.02e-15 Homoarginine levels; LUSC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.39 0.37 1.21e-12 Schizophrenia; LUSC cis rs4285028 0.847 rs1986712 chr3:121710986 A/G cg20356878 chr3:121714668 ILDR1 -0.45 -5.81 -0.3 1.49e-8 Multiple sclerosis; LUSC cis rs6977660 0.714 rs17141945 chr7:19805056 T/A cg05791153 chr7:19748676 TWISTNB 0.69 7.43 0.38 9.12e-13 Thyroid stimulating hormone; LUSC cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.66 -0.6 4.86e-34 Chronic sinus infection; LUSC cis rs7399018 0.739 rs7953955 chr12:51608467 A/G cg10377582 chr12:51612794 POU6F1 -0.34 -5.82 -0.3 1.41e-8 Cisplatin-induced ototoxicity; LUSC cis rs17401966 0.898 rs11587495 chr1:10448999 T/C cg19773385 chr1:10388646 KIF1B -0.54 -9.03 -0.44 1.35e-17 Hepatocellular carcinoma; LUSC trans rs61931739 0.500 rs6488209 chr12:34319309 A/G cg13010199 chr12:38710504 ALG10B 0.47 7.33 0.37 1.75e-12 Morning vs. evening chronotype; LUSC cis rs8072100 0.846 rs6503796 chr17:45765249 T/C cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.39 -6.23 -0.32 1.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs870825 0.929 rs72689255 chr4:185590141 T/C cg04058563 chr4:185651563 MLF1IP 0.89 11.84 0.54 3.17e-27 Blood protein levels; LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg14092988 chr3:52407081 DNAH1 0.31 6.12 0.32 2.56e-9 Bipolar disorder; LUSC cis rs61931739 0.534 rs7313137 chr12:34010231 T/G cg06521331 chr12:34319734 NA -0.48 -7.67 -0.39 1.84e-13 Morning vs. evening chronotype; LUSC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg09021430 chr5:549028 NA -0.54 -7.18 -0.37 4.43e-12 Obesity-related traits; LUSC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg09034736 chr1:150693464 HORMAD1 -0.43 -6.36 -0.33 6.47e-10 Tonsillectomy; LUSC cis rs965513 1.000 rs4743130 chr9:100546040 C/T cg13688889 chr9:100608707 NA -0.55 -8.14 -0.41 7.97e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.11e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg06064525 chr11:970664 AP2A2 -0.48 -10.71 -0.51 3.45e-23 Alzheimer's disease (late onset); LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.96 -13.31 -0.59 9.89e-33 Alzheimer's disease; LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg07092213 chr7:1199455 ZFAND2A -0.44 -7.05 -0.36 1.03e-11 Longevity;Endometriosis; LUSC cis rs753778 0.570 rs10875465 chr8:142210500 A/G cg18755752 chr8:142205143 DENND3 -0.67 -12.05 -0.55 5.24e-28 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC trans rs61931739 0.517 rs12815556 chr12:34319670 G/A cg26384229 chr12:38710491 ALG10B 0.73 11.89 0.55 2.05e-27 Morning vs. evening chronotype; LUSC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.64 -14.21 -0.61 3.52e-36 Hemoglobin concentration; LUSC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg02423579 chr7:2872169 GNA12 -0.48 -6.64 -0.34 1.29e-10 Height; LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg08472276 chr7:1133186 C7orf50;GPER -0.37 -6.05 -0.31 3.95e-9 Longevity;Endometriosis; LUSC cis rs1950626 0.569 rs4143956 chr14:101434356 A/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.47 0.38 7.07e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg05368731 chr17:41323189 NBR1 0.93 15.72 0.65 4.37e-42 Menopause (age at onset); LUSC cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.48 0.42 7.38e-16 Colorectal cancer; LUSC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg13114125 chr14:105738426 BRF1 -0.87 -14.7 -0.63 4.53e-38 Platelet count; LUSC cis rs9910055 1.000 rs9910055 chr17:42283037 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.49 8.15 0.41 7.28e-15 Total body bone mineral density; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg15218456 chr17:25289681 NA 0.44 6.11 0.32 2.74e-9 Calcium levels; LUSC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg10018233 chr7:150070692 REPIN1 0.38 6.54 0.34 2.32e-10 Blood protein levels;Circulating chemerin levels; LUSC trans rs11696501 0.688 rs6073850 chr20:44301084 C/T cg03272292 chr12:48577362 C12orf68 0.53 6.34 0.33 7.41e-10 Brain structure; LUSC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg25258033 chr6:167368657 RNASET2 0.47 7.82 0.39 7.18e-14 Crohn's disease; LUSC cis rs10992471 0.603 rs13301537 chr9:95229047 A/G cg14631576 chr9:95140430 CENPP -0.34 -6.17 -0.32 1.97e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18404041 chr3:52824283 ITIH1 0.43 8.23 0.41 4.3e-15 Electroencephalogram traits; LUSC cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg08085267 chr17:45401833 C17orf57 -0.47 -6.62 -0.34 1.47e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3092073 0.624 rs7275164 chr20:44604822 G/A cg23303369 chr20:44641161 MMP9 0.38 6.58 0.34 1.83e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg21724239 chr8:58056113 NA 0.74 6.34 0.33 7.32e-10 Developmental language disorder (linguistic errors); LUSC cis rs290268 0.838 rs1333635 chr9:93566406 A/G cg02608019 chr9:93564028 SYK 0.54 9.43 0.46 7.11e-19 Platelet count; LUSC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg06028605 chr16:24865363 SLC5A11 0.61 9.46 0.46 5.74e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs643955 0.609 rs13259465 chr8:9982953 C/G cg15556689 chr8:8085844 FLJ10661 -0.48 -6.67 -0.34 1.06e-10 Systemic lupus erythematosus; LUSC cis rs12980942 0.872 rs3752705 chr19:41798111 A/G cg25627403 chr19:41769009 HNRNPUL1 0.63 6.84 0.35 3.89e-11 Coronary artery disease; LUSC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg24531977 chr5:56204891 C5orf35 -1.01 -15.03 -0.64 2.33e-39 Initial pursuit acceleration; LUSC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -7.96 -0.4 2.77e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg12639453 chr1:2035780 PRKCZ -0.32 -7.08 -0.36 8.63e-12 Height; LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.47 -6.54 -0.34 2.34e-10 Gut microbiome composition (summer); LUSC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg18827107 chr12:86230957 RASSF9 -0.5 -7.46 -0.38 7.71e-13 Major depressive disorder; LUSC cis rs806215 0.951 rs327510 chr7:127257894 G/A cg25922125 chr7:127225783 GCC1 0.49 6.36 0.33 6.61e-10 Type 2 diabetes; LUSC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.62 0.5 6.6e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4243830 0.850 rs57203351 chr1:6601319 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.88 10.45 0.5 2.57e-22 Body mass index; LUSC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg08847533 chr14:75593920 NEK9 0.85 15.75 0.65 3.43e-42 Height; LUSC cis rs2562456 0.720 rs6511250 chr19:21656046 C/T cg00806126 chr19:22604979 ZNF98 0.4 6.26 0.32 1.18e-9 Pain; LUSC cis rs17095355 1.000 rs12570820 chr10:111732507 G/A cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.54 -0.38 4.55e-13 Biliary atresia; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.33 0.56 4.75e-29 Prudent dietary pattern; LUSC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg18876405 chr7:65276391 NA -0.57 -9.35 -0.46 1.26e-18 Aortic root size; LUSC cis rs7605827 0.930 rs6735633 chr2:15706096 G/A cg19274914 chr2:15703543 NA 0.46 8.94 0.44 2.77e-17 Educational attainment (years of education); LUSC cis rs7659604 0.540 rs11934307 chr4:122677514 G/A cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs17685 0.712 rs1859794 chr7:75821544 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.48 -7.21 -0.37 3.74e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs11583043 1.000 rs12750667 chr1:101498682 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 6.11 0.32 2.76e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs61931739 0.613 rs1525898 chr12:33904445 G/T cg26384229 chr12:38710491 ALG10B 0.51 7.68 0.39 1.82e-13 Morning vs. evening chronotype; LUSC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg03517284 chr6:25882590 NA 0.65 11.4 0.53 1.23e-25 Blood metabolite levels; LUSC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg03433033 chr1:76189801 ACADM 0.78 10.89 0.51 7.61e-24 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg18721089 chr20:30220636 NA -0.38 -6.32 -0.33 8.15e-10 Mean corpuscular hemoglobin; LUSC trans rs6502050 0.698 rs67143649 chr17:80117772 C/G cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.88e-10 Life satisfaction; LUSC cis rs6489882 0.703 rs10850092 chr12:113359703 C/G cg20102336 chr12:113376681 OAS3 -0.41 -5.79 -0.3 1.59e-8 Chronic lymphocytic leukemia; LUSC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg17366294 chr4:99064904 C4orf37 0.55 9.8 0.47 4.17e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg09184832 chr6:79620586 NA 0.43 6.9 0.35 2.58e-11 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg08219700 chr8:58056026 NA 0.67 6.31 0.33 8.71e-10 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25193484 chr1:43282654 ERMAP;CCDC23 0.81 6.63 0.34 1.35e-10 Cognitive performance; LUSC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg12311346 chr5:56204834 C5orf35 -0.55 -8.26 -0.41 3.34e-15 Coronary artery disease; LUSC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg18512352 chr11:47633146 NA -0.46 -9.21 -0.45 3.67e-18 Subjective well-being; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08206623 chr11:2907334 CDKN1C 0.38 6.42 0.33 4.73e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7640424 0.649 rs13091474 chr3:107877134 A/T cg09227934 chr3:107805635 CD47 -0.36 -5.71 -0.3 2.51e-8 Body mass index; LUSC cis rs5769707 0.605 rs9616702 chr22:50025938 A/G cg05373962 chr22:49881684 NA -0.41 -8.79 -0.43 8.29e-17 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg10802521 chr3:52805072 NEK4 -0.55 -8.67 -0.43 1.92e-16 Bipolar disorder; LUSC cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg09165964 chr15:75287851 SCAMP5 -0.47 -6.79 -0.35 5.1e-11 Systemic lupus erythematosus; LUSC cis rs7829975 0.714 rs4840362 chr8:8670082 C/G cg08975724 chr8:8085496 FLJ10661 -0.49 -7.39 -0.37 1.23e-12 Mood instability; LUSC trans rs8072100 0.811 rs1912483 chr17:45443494 A/G cg04995722 chr7:26192034 NFE2L3 -0.4 -6.36 -0.33 6.8e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2464469 0.654 rs4646570 chr15:58343146 G/C cg12031962 chr15:58353849 ALDH1A2 -0.32 -5.85 -0.31 1.15e-8 Barrett's esophagus or Esophageal adenocarcinoma; LUSC cis rs9640161 0.789 rs66688634 chr7:150053806 G/A cg21361702 chr7:150065534 REPIN1 0.57 8.07 0.4 1.25e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Melanoma; LUSC cis rs8031584 0.578 rs1088473 chr15:31139298 A/G cg08109568 chr15:31115862 NA 0.74 11.09 0.52 1.47e-24 Huntington's disease progression; LUSC cis rs4478858 0.735 rs6425737 chr1:31790288 T/C cg00250761 chr1:31883323 NA -0.35 -8.72 -0.43 1.35e-16 Alcohol dependence; LUSC cis rs12190007 0.573 rs3006218 chr6:169868769 G/A cg15038512 chr6:170123185 PHF10 -0.4 -6.55 -0.34 2.17e-10 Obesity-related traits; LUSC cis rs4343996 0.558 rs11761186 chr7:3412450 A/G cg21248987 chr7:3385318 SDK1 0.37 6.23 0.32 1.38e-9 Motion sickness; LUSC cis rs7577696 0.597 rs212689 chr2:32437338 G/A cg02381751 chr2:32503542 YIPF4 0.53 6.84 0.35 3.76e-11 Inflammatory biomarkers; LUSC cis rs34779708 0.966 rs10508816 chr10:35459976 G/A cg03585969 chr10:35415529 CREM 0.6 8.95 0.44 2.53e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9467711 0.606 rs2073531 chr6:26375256 A/G cg09904177 chr6:26538194 HMGN4 -0.74 -6.95 -0.36 1.9e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg22029157 chr1:209979665 IRF6 0.8 10.25 0.49 1.27e-21 Cleft lip with or without cleft palate; LUSC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg03929089 chr4:120376271 NA -1.02 -19.67 -0.73 9.47e-58 Height; LUSC cis rs7017697 1.000 rs7017697 chr8:19685909 G/T cg03894339 chr8:19674705 INTS10 -0.48 -6.84 -0.35 3.7e-11 Breast cancer; LUSC cis rs193541 0.564 rs407230 chr5:122345727 G/A cg19077854 chr5:122220652 SNX24 -0.4 -8.29 -0.41 2.76e-15 Glucose homeostasis traits; LUSC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg10523679 chr1:76189770 ACADM -0.9 -15.73 -0.65 4e-42 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs9291683 0.509 rs998676 chr4:9948564 T/C cg26043149 chr18:55253948 FECH -0.44 -6.69 -0.34 9.38e-11 Bone mineral density; LUSC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg00149659 chr3:10157352 C3orf10 1.01 14.42 0.62 5.3e-37 Alzheimer's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26539232 chr19:924834 ARID3A 0.42 6.3 0.33 9.14e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs877282 0.628 rs11253435 chr10:824169 T/C cg13775593 chr10:823151 NA 0.32 6.4 0.33 5.22e-10 Uric acid levels; LUSC cis rs155346 1.000 rs265149 chr5:139401891 G/A cg01090482 chr5:139365336 NRG2 -0.36 -5.74 -0.3 2.07e-8 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg19592336 chr6:28129416 ZNF389 0.46 6.01 0.31 4.81e-9 Depression; LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg22920501 chr2:26401640 FAM59B -0.79 -11.8 -0.54 4.09e-27 Gut microbiome composition (summer); LUSC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.77e-16 Aortic root size; LUSC cis rs6987853 0.787 rs2974335 chr8:42417272 C/T cg09913449 chr8:42400586 C8orf40 0.53 9.19 0.45 4.2e-18 Mean corpuscular hemoglobin concentration; LUSC cis rs2573652 0.722 rs11630930 chr15:100544145 G/T cg09918751 chr15:100517450 ADAMTS17 -0.3 -5.76 -0.3 1.86e-8 Height; LUSC cis rs7113850 0.541 rs11819948 chr11:24231257 A/C ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Bone fracture in osteoporosis; LUSC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg19592336 chr6:28129416 ZNF389 0.46 5.93 0.31 7.48e-9 Parkinson's disease; LUSC cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg09526685 chr4:187126073 CYP4V2 0.64 6.32 0.33 8.41e-10 Blood protein levels; LUSC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg09913183 chr17:42254507 C17orf65;ASB16 0.53 7.39 0.37 1.17e-12 Total body bone mineral density; LUSC trans rs2236293 0.755 rs10758325 chr9:35804149 A/G cg11239633 chr3:37903682 CTDSPL 0.35 6.35 0.33 6.92e-10 Blood protein levels; LUSC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg04352962 chr1:209979756 IRF6 0.55 6.46 0.33 3.73e-10 Cleft lip with or without cleft palate; LUSC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg22029157 chr1:209979665 IRF6 0.51 8.12 0.41 9e-15 Monobrow; LUSC cis rs1577917 0.655 rs9342045 chr6:86425148 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.37 5.84 0.3 1.23e-8 Response to antipsychotic treatment; LUSC cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.46e-35 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25942691 chr19:36705733 ZNF565;ZNF146 0.45 6.08 0.32 3.36e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs16854884 1.000 rs13067695 chr3:143781054 C/T cg06585982 chr3:143692056 C3orf58 0.47 6.61 0.34 1.51e-10 Economic and political preferences (feminism/equality); LUSC cis rs12493885 0.697 rs11710478 chr3:153777037 A/C cg17054900 chr3:154042577 DHX36 -0.72 -7.06 -0.36 9.58e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14452650 chr2:42396274 EML4 0.41 6.72 0.35 7.72e-11 Asthma; LUSC cis rs4718428 0.705 rs4718430 chr7:66432024 G/T cg18252515 chr7:66147081 NA -0.47 -5.96 -0.31 6.55e-9 Corneal structure; LUSC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg26597838 chr10:835615 NA 0.79 9.74 0.47 6.95e-20 Eosinophil percentage of granulocytes; LUSC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7681440 0.904 rs6816305 chr4:90772902 C/G cg01966878 chr4:90757139 SNCA -0.34 -5.93 -0.31 7.6e-9 Dementia with Lewy bodies; LUSC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg00750074 chr16:89608354 SPG7 -0.58 -10.55 -0.5 1.21e-22 Multiple myeloma (IgH translocation); LUSC cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg06784218 chr1:46089804 CCDC17 -0.47 -8.88 -0.44 4.2e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11676348 0.710 rs11894169 chr2:219046846 T/C cg06547715 chr2:218990976 CXCR2 -0.33 -6.29 -0.33 9.87e-10 Ulcerative colitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03901462 chr11:62572874 NXF1 -0.49 -6.21 -0.32 1.56e-9 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg08859206 chr1:53392774 SCP2 0.56 9.89 0.48 2.1e-20 Monocyte count; LUSC cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.46 7.07 0.36 9.04e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs11098499 0.909 rs28571712 chr4:120375980 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.4e-10 Corneal astigmatism; LUSC cis rs1878931 0.543 rs1129568 chr16:3483475 G/A cg00484396 chr16:3507460 NAT15 -0.45 -7.0 -0.36 1.43e-11 Body mass index (adult); LUSC cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg05283184 chr6:79620031 NA -0.57 -12.15 -0.55 2.25e-28 Intelligence (multi-trait analysis); LUSC cis rs734999 0.588 rs2843401 chr1:2528133 T/C cg18932078 chr1:2524107 MMEL1 -0.33 -7.15 -0.36 5.47e-12 Ulcerative colitis; LUSC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11644478 chr21:40555479 PSMG1 -0.67 -10.43 -0.5 3.04e-22 Menarche (age at onset); LUSC cis rs28595532 0.748 rs17594978 chr4:119336398 T/C cg02775129 chr4:119771670 NA -0.76 -6.32 -0.33 8.37e-10 Cannabis dependence symptom count; LUSC cis rs2295359 1.000 rs4655682 chr1:67610967 C/T cg03340356 chr1:67600835 NA 0.42 6.69 0.34 9.68e-11 Psoriasis; LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13732083 chr21:47605072 C21orf56 0.43 6.35 0.33 6.83e-10 Testicular germ cell tumor; LUSC cis rs10210302 0.502 rs880116 chr2:234246264 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.45 6.45 0.33 4.04e-10 Crohn's disease; LUSC trans rs11098499 0.954 rs3733524 chr4:120423729 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.04 0.4 1.62e-14 Corneal astigmatism; LUSC cis rs11155671 0.530 rs9371223 chr6:150214806 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.79 -0.3 1.64e-8 Testicular germ cell tumor; LUSC cis rs4423214 1.000 rs2852853 chr11:71150217 C/T cg05163923 chr11:71159392 DHCR7 0.7 10.46 0.5 2.44e-22 Vitamin D levels; LUSC cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg08045932 chr20:61659980 NA 0.55 9.23 0.45 3.17e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs3768617 0.811 rs12043805 chr1:183008150 T/A ch.1.3577855R chr1:183094577 LAMC1 0.6 8.54 0.42 4.75e-16 Fuchs's corneal dystrophy; LUSC cis rs17030434 0.954 rs11724154 chr4:154753108 G/T cg14289246 chr4:154710475 SFRP2 -0.52 -6.83 -0.35 4.15e-11 Electrocardiographic conduction measures; LUSC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg09988129 chr7:74988866 PMS2L2;STAG3L1 0.53 8.41 0.42 1.24e-15 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4594175 0.926 rs11624975 chr14:51628347 T/C cg23942311 chr14:51606299 NA 0.31 5.83 0.3 1.33e-8 Cancer; LUSC cis rs6942756 0.840 rs963465 chr7:128875612 C/G cg02491457 chr7:128862824 NA 0.52 7.86 0.4 5.21e-14 White matter hyperintensity burden; LUSC cis rs478304 0.718 rs1151490 chr11:65390485 A/C cg27068330 chr11:65405492 SIPA1 0.66 9.46 0.46 5.75e-19 Acne (severe); LUSC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.54 -9.0 -0.44 1.71e-17 Lymphocyte counts; LUSC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg09455208 chr3:40491958 NA 0.59 10.13 0.48 3.39e-21 Renal cell carcinoma; LUSC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg02807482 chr3:125708958 NA -0.52 -6.51 -0.34 2.69e-10 Blood pressure (smoking interaction); LUSC cis rs6681460 0.934 rs4655628 chr1:67052609 T/C cg02459107 chr1:67143332 SGIP1 0.46 8.51 0.42 5.83e-16 Presence of antiphospholipid antibodies; LUSC cis rs6546537 1.000 rs17036866 chr2:69857711 T/C cg10773587 chr2:69614142 GFPT1 -0.54 -8.1 -0.41 1.07e-14 Serum thyroid-stimulating hormone levels; LUSC cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg13609457 chr4:120235615 NA 0.42 5.66 0.3 3.31e-8 Corneal astigmatism; LUSC trans rs12579753 0.917 rs11610365 chr12:82218108 C/T cg07923666 chr12:49932857 KCNH3 -0.49 -6.12 -0.32 2.55e-9 Resting heart rate; LUSC cis rs10493773 0.775 rs12564080 chr1:86196586 A/C cg17807903 chr1:86174739 ZNHIT6 -0.5 -12.09 -0.55 3.55e-28 Urate levels in overweight individuals; LUSC cis rs7560272 0.538 rs35767294 chr2:73922834 A/G cg20560298 chr2:73613845 ALMS1 0.38 5.87 0.31 1.06e-8 Schizophrenia; LUSC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.66 6.3 0.33 9.47e-10 Cerebrospinal P-tau181p levels; LUSC cis rs1832871 0.672 rs9457363 chr6:158777515 C/T cg07165851 chr6:158734300 TULP4 0.46 7.16 0.36 5.04e-12 Height; LUSC cis rs921665 0.749 rs2368682 chr2:3197387 C/T cg16434511 chr2:3151078 NA -0.61 -6.64 -0.34 1.29e-10 World class endurance athleticism; LUSC cis rs11997175 0.646 rs2006792 chr8:33694423 G/A ch.8.33884649F chr8:33765107 NA 0.45 6.65 0.34 1.2e-10 Body mass index; LUSC cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg16339924 chr4:17578868 LAP3 0.61 9.31 0.45 1.8e-18 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.84 -0.3 1.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg20135002 chr11:47629003 NA -0.52 -8.17 -0.41 6.65e-15 Subjective well-being; LUSC cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg08564027 chr20:61660810 NA 0.91 17.17 0.68 8.22e-48 Prostate cancer (SNP x SNP interaction); LUSC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg20891283 chr12:69753455 YEATS4 0.63 10.36 0.49 5.57e-22 Response to diuretic therapy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25088355 chr8:144691901 PYCRL -0.44 -6.61 -0.34 1.49e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08039791 chr14:21945223 RAB2B;TOX4 -0.41 -6.12 -0.32 2.59e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7577696 0.785 rs11689817 chr2:32364241 T/A cg02381751 chr2:32503542 YIPF4 -0.44 -6.22 -0.32 1.53e-9 Inflammatory biomarkers; LUSC trans rs1997103 0.906 rs6593231 chr7:55402914 T/A cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg21963583 chr11:68658836 MRPL21 0.56 8.68 0.43 1.81e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg11764359 chr7:65958608 NA 0.7 11.0 0.52 3.29e-24 Aortic root size; LUSC cis rs5769765 0.913 rs2319462 chr22:50263370 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.63 0.5 6.32e-23 Schizophrenia; LUSC cis rs4494114 1.000 rs12127091 chr1:39339449 C/T cg25970120 chr1:39325951 RRAGC -0.4 -6.27 -0.32 1.14e-9 Blood protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07870003 chr12:107381075 MTERFD3 0.52 7.21 0.37 3.84e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7605378 1.000 rs7605378 chr2:200676926 A/C cg17644776 chr2:200775616 C2orf69 0.37 5.78 0.3 1.75e-8 Osteoporosis; LUSC cis rs6076065 0.723 rs2424537 chr20:23382026 T/C cg11657817 chr20:23433608 CST11 0.42 7.93 0.4 3.31e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs1577917 0.958 rs12196377 chr6:86566775 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.72 -0.35 7.84e-11 Response to antipsychotic treatment; LUSC cis rs6969780 1.000 rs6461985 chr7:27150634 T/C cg26364809 chr7:27145159 NA -0.59 -5.91 -0.31 8.35e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg17971929 chr21:40555470 PSMG1 0.8 14.27 0.62 2.18e-36 Cognitive function; LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.29e-12 Platelet count; LUSC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg06637938 chr14:75390232 RPS6KL1 0.53 8.52 0.42 5.51e-16 Height; LUSC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.41 -0.33 5.09e-10 Total body bone mineral density; LUSC cis rs7215564 0.818 rs34754307 chr17:78652758 C/G cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg25817165 chr18:72167213 CNDP2 -0.75 -11.17 -0.52 8.07e-25 Refractive error; LUSC cis rs243505 0.762 rs1019218 chr7:148488964 C/T cg09806900 chr7:148480153 CUL1 0.58 8.51 0.42 5.84e-16 Inflammatory bowel disease;Crohn's disease; LUSC trans rs877282 0.898 rs34490091 chr10:765800 A/C cg13042288 chr15:90349979 ANPEP -0.47 -6.41 -0.33 4.97e-10 Uric acid levels; LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg22963979 chr7:1858916 MAD1L1 -0.61 -9.72 -0.47 7.72e-20 Bipolar disorder and schizophrenia; LUSC cis rs2637266 0.538 rs2637246 chr10:78272913 G/A cg18941641 chr10:78392320 NA 0.33 6.03 0.31 4.32e-9 Pulmonary function; LUSC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs9902453 1.000 rs55971458 chr17:28427016 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.59 0.43 3.35e-16 Coffee consumption (cups per day); LUSC cis rs8017423 0.967 rs8016385 chr14:90721946 G/A cg14092571 chr14:90743983 NA -0.35 -5.83 -0.3 1.29e-8 Mortality in heart failure; LUSC cis rs240764 0.554 rs6570970 chr6:101233082 C/A cg09795085 chr6:101329169 ASCC3 0.44 6.27 0.32 1.13e-9 Neuroticism; LUSC cis rs7914558 0.966 rs10748839 chr10:104953547 A/G cg05855489 chr10:104503620 C10orf26 0.59 9.6 0.46 1.99e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs12483240 0.793 rs10154112 chr21:26819664 C/T cg08463788 chr1:197888068 LHX9 -0.66 -6.06 -0.31 3.76e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9788682 0.747 rs7174190 chr15:78763617 C/T cg18825076 chr15:78729989 IREB2 0.44 6.13 0.32 2.46e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7954584 0.531 rs6486781 chr12:122318985 A/C cg01765077 chr12:122356316 WDR66 0.5 6.85 0.35 3.63e-11 Mean corpuscular volume; LUSC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg27398817 chr8:82754497 SNX16 -0.47 -6.21 -0.32 1.58e-9 Diastolic blood pressure; LUSC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg16405210 chr4:1374714 KIAA1530 -0.53 -8.02 -0.4 1.84e-14 Obesity-related traits; LUSC trans rs75804782 0.581 rs3191996 chr2:239344412 A/G cg01134436 chr17:81009848 B3GNTL1 -0.64 -6.43 -0.33 4.4e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs2404602 0.647 rs11072610 chr15:76930805 C/A cg23625390 chr15:77176239 SCAPER -0.64 -9.69 -0.47 9.62e-20 Blood metabolite levels; LUSC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.85e-12 Reticulocyte fraction of red cells; LUSC cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg23711669 chr6:146136114 FBXO30 0.75 13.38 0.59 5.46e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs9517313 0.592 rs61969458 chr13:99177633 A/G cg20487152 chr13:99095054 FARP1 -0.41 -6.83 -0.35 4.06e-11 Neuroticism; LUSC cis rs709400 0.663 rs9671911 chr14:103967343 T/C cg04998671 chr14:104000505 TRMT61A 0.36 5.66 0.3 3.33e-8 Body mass index; LUSC cis rs2354432 0.556 rs4295925 chr1:146857335 T/C cg25205988 chr1:146714368 CHD1L 0.88 7.92 0.4 3.6e-14 Mitochondrial DNA levels; LUSC cis rs240764 0.817 rs239239 chr6:101094554 A/G cg09795085 chr6:101329169 ASCC3 0.42 6.09 0.32 3.09e-9 Neuroticism; LUSC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg09323728 chr8:95962352 TP53INP1 -0.45 -9.45 -0.46 6.1e-19 Type 2 diabetes; LUSC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg08677398 chr8:58056175 NA 0.51 6.33 0.33 7.97e-10 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.930 rs7596435 chr2:15605091 T/C cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg16049864 chr8:95962084 TP53INP1 -0.62 -11.6 -0.54 2.3e-26 Type 2 diabetes; LUSC cis rs2108225 0.872 rs4618632 chr7:107440952 T/G cg18560240 chr7:107437656 SLC26A3 -0.44 -6.5 -0.34 2.91e-10 Ulcerative colitis; LUSC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg00166722 chr3:10149974 C3orf24 0.59 7.65 0.39 2.17e-13 Alzheimer's disease; LUSC cis rs3862030 0.720 rs11593526 chr10:104228017 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.56 -8.78 -0.43 8.85e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs10979 0.679 rs2275345 chr6:143872960 G/A cg25407410 chr6:143891975 LOC285740 -0.62 -8.69 -0.43 1.65e-16 Hypospadias; LUSC cis rs9300255 0.569 rs1716170 chr12:123716513 C/T cg00376283 chr12:123451042 ABCB9 0.65 8.3 0.41 2.63e-15 Neutrophil percentage of white cells; LUSC cis rs983392 0.836 rs72918674 chr11:59944580 C/T cg02771260 chr11:59836817 MS4A3 -0.37 -5.87 -0.31 1.06e-8 Alzheimer's disease (late onset); LUSC cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg23992470 chr4:843637 GAK 0.56 6.53 0.34 2.46e-10 Intelligence (multi-trait analysis); LUSC cis rs612683 0.826 rs7556246 chr1:100828914 A/G cg06223162 chr1:101003688 GPR88 0.39 7.12 0.36 6.67e-12 Breast cancer; LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg16362232 chr11:430036 ANO9 0.63 7.92 0.4 3.5e-14 Body mass index; LUSC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg20406979 chr6:167373233 NA -0.26 -6.07 -0.32 3.4e-9 Crohn's disease; LUSC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg12463550 chr7:65579703 CRCP -0.48 -7.19 -0.37 4.32e-12 Aortic root size; LUSC cis rs4654899 0.931 rs10799669 chr1:21172501 T/C cg01072550 chr1:21505969 NA 0.49 7.34 0.37 1.65e-12 Superior frontal gyrus grey matter volume; LUSC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs41271473 0.526 rs72765760 chr1:228743222 G/A cg10167378 chr1:228756711 NA 0.76 10.11 0.48 3.94e-21 Chronic lymphocytic leukemia; LUSC cis rs7605827 0.897 rs4459705 chr2:15526584 C/T cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs11166629 1.000 rs2315838 chr8:135645968 C/T cg27224718 chr8:135614730 ZFAT 0.63 10.52 0.5 1.48e-22 Smoking quantity; LUSC cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg18132916 chr6:79620363 NA -0.38 -5.77 -0.3 1.8e-8 Intelligence (multi-trait analysis); LUSC cis rs151349 1.000 rs151344 chr20:57585301 A/G cg23907860 chr20:57583709 CTSZ -0.48 -7.9 -0.4 3.95e-14 Platelet distribution width; LUSC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg17330251 chr7:94953956 PON1 -0.38 -6.17 -0.32 1.92e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs11958404 0.932 rs10045597 chr5:157451963 T/C cg05962755 chr5:157440814 NA 0.47 5.93 0.31 7.43e-9 IgG glycosylation; LUSC cis rs7614311 0.681 rs2241822 chr3:63965304 A/G cg22134162 chr3:63841271 THOC7 -0.5 -6.07 -0.32 3.5e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs9434723 0.920 rs2239560 chr1:9304731 C/T cg04199779 chr1:9294473 H6PD 0.54 6.3 0.33 9.48e-10 Height; LUSC trans rs561341 1.000 rs484175 chr17:30309041 G/A cg27661571 chr11:113659931 NA -0.67 -7.74 -0.39 1.16e-13 Hip circumference adjusted for BMI; LUSC cis rs9303401 0.659 rs11495824 chr17:56918882 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.87 13.35 0.59 7.08e-33 Cognitive test performance; LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg13560548 chr3:10150139 C3orf24 0.52 7.14 0.36 5.82e-12 Alzheimer's disease; LUSC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg23093090 chr10:104574429 C10orf26 -0.37 -6.94 -0.36 2.02e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs12980942 0.872 rs12974420 chr19:41798660 A/G cg25627403 chr19:41769009 HNRNPUL1 0.63 6.79 0.35 5.05e-11 Coronary artery disease; LUSC cis rs4243830 1.000 rs41278016 chr1:6584045 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.93 9.08 0.44 9.68e-18 Body mass index; LUSC cis rs2413583 0.591 rs17305131 chr22:39718564 T/C cg17798944 chr22:39715225 SNORD43;RPL3 0.67 6.41 0.33 4.86e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.55 9.44 0.46 6.42e-19 Prudent dietary pattern; LUSC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg06634786 chr22:41940651 POLR3H -0.54 -6.22 -0.32 1.49e-9 Vitiligo; LUSC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21582582 chr3:182698605 DCUN1D1 0.46 8.2 0.41 5.18e-15 Intelligence (multi-trait analysis); LUSC cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg05868516 chr6:26286170 HIST1H4H 0.37 6.14 0.32 2.29e-9 Educational attainment; LUSC cis rs4363385 0.510 rs7531076 chr1:153039167 G/T cg00922841 chr1:152955080 SPRR1A -0.37 -6.19 -0.32 1.72e-9 Inflammatory skin disease; LUSC cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.77 0.57 1.06e-30 Motion sickness; LUSC cis rs4481887 0.676 rs7524978 chr1:248527319 A/T cg26353448 chr1:248524236 OR2T4 -0.32 -6.12 -0.32 2.63e-9 Common traits (Other); LUSC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg17971929 chr21:40555470 PSMG1 0.73 11.94 0.55 1.28e-27 Cognitive function; LUSC cis rs5753037 0.809 rs140150 chr22:30185719 C/G cg11564601 chr22:30592435 NA 0.33 5.84 0.3 1.23e-8 Type 1 diabetes; LUSC cis rs611744 0.647 rs1457211 chr8:109261318 C/T cg18478394 chr8:109455254 TTC35 -0.42 -6.5 -0.34 2.87e-10 Dupuytren's disease; LUSC cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22857025 chr5:266934 NA -1.21 -14.54 -0.62 1.92e-37 Breast cancer; LUSC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.73 0.63 3.45e-38 Platelet count; LUSC cis rs614226 0.872 rs787827 chr12:120937794 A/G cg01236616 chr12:121019343 POP5 1.3 21.62 0.76 1.91e-65 Type 1 diabetes nephropathy; LUSC cis rs12042938 0.600 rs1094656 chr1:231773675 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.4 5.95 0.31 6.92e-9 Neuranatomic and neurocognitive phenotypes; LUSC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg02187348 chr16:89574699 SPG7 0.61 9.92 0.48 1.75e-20 Multiple myeloma (IgH translocation); LUSC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg22823121 chr1:150693482 HORMAD1 0.49 7.28 0.37 2.48e-12 Melanoma; LUSC trans rs11992162 0.636 rs4841644 chr8:11798433 A/C cg15556689 chr8:8085844 FLJ10661 0.48 6.83 0.35 4.05e-11 Monocyte count; LUSC cis rs2288073 0.801 rs10176347 chr2:24367994 G/A cg20701182 chr2:24300061 SF3B14 0.52 6.74 0.35 6.86e-11 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg01448562 chr3:133502909 NA -0.52 -7.75 -0.39 1.13e-13 Iron status biomarkers; LUSC cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg08999081 chr20:33150536 PIGU 0.43 7.33 0.37 1.77e-12 Coronary artery disease; LUSC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC trans rs17685 0.712 rs1637049 chr7:75729975 C/G cg06486467 chr15:102282101 NA -0.38 -5.95 -0.31 6.88e-9 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4888262 0.526 rs12921903 chr16:74625575 C/T cg01733217 chr16:74700730 RFWD3 0.81 13.44 0.59 3.34e-33 Testicular germ cell tumor; LUSC cis rs7223966 1.000 rs17549954 chr17:61707032 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.7 0.34 8.72e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs73195822 0.667 rs117806977 chr12:111235324 C/T cg12870014 chr12:110450643 ANKRD13A 0.7 6.57 0.34 1.96e-10 Itch intensity from mosquito bite; LUSC cis rs877282 0.898 rs12354872 chr10:763362 G/A cg17470449 chr10:769945 NA 0.53 7.13 0.36 6.24e-12 Uric acid levels; LUSC cis rs950169 0.922 rs4842940 chr15:84831225 C/T cg12863693 chr15:85201151 NMB -0.35 -7.24 -0.37 3.1e-12 Schizophrenia; LUSC cis rs7659604 0.521 rs10001697 chr4:122677737 G/T cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg05234568 chr11:5960015 NA -0.55 -8.68 -0.43 1.83e-16 DNA methylation (variation); LUSC cis rs9457247 1.000 rs413232 chr6:167400972 G/A cg07741184 chr6:167504864 NA 0.36 6.53 0.34 2.52e-10 Crohn's disease; LUSC cis rs1355223 0.573 rs1148930 chr11:34732225 C/T cg11058730 chr11:34937778 PDHX;APIP 0.41 5.72 0.3 2.4e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs67311347 0.713 rs114569261 chr3:40314580 G/A cg02782426 chr3:40428986 ENTPD3 0.34 6.72 0.34 8.08e-11 Renal cell carcinoma; LUSC cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg06784218 chr1:46089804 CCDC17 0.49 9.92 0.48 1.68e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504073 0.647 rs10808745 chr8:49989037 G/A cg00325661 chr8:49890786 NA 0.62 9.97 0.48 1.12e-20 Blood metabolite ratios; LUSC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg03709012 chr19:19516395 GATAD2A 0.87 14.79 0.63 1.95e-38 Tonsillectomy; LUSC cis rs3815700 1.000 rs8104726 chr19:33094675 G/A cg02997394 chr19:33096574 ANKRD27 0.79 8.95 0.44 2.49e-17 Eosinophilic esophagitis; LUSC cis rs35146811 0.807 rs6465761 chr7:99620277 G/C cg13334819 chr7:99746414 C7orf59 -0.43 -5.73 -0.3 2.26e-8 Coronary artery disease; LUSC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.01e-10 Blood pressure (smoking interaction); LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg21724239 chr8:58056113 NA 0.79 9.5 0.46 4.34e-19 Developmental language disorder (linguistic errors); LUSC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.67 -9.93 -0.48 1.54e-20 Systemic lupus erythematosus; LUSC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.47 5.69 0.3 2.75e-8 Renal function-related traits (BUN); LUSC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg03929089 chr4:120376271 NA -1.04 -20.46 -0.75 7.01e-61 Height; LUSC cis rs66887589 0.777 rs10015883 chr4:120268146 A/G cg24375607 chr4:120327624 NA 0.51 7.87 0.4 4.84e-14 Diastolic blood pressure; LUSC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg02187348 chr16:89574699 SPG7 0.62 10.11 0.48 4e-21 Multiple myeloma (IgH translocation); LUSC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.44 7.38 0.37 1.25e-12 Bipolar disorder; LUSC trans rs1814175 0.791 rs11040472 chr11:49703116 C/T cg03929089 chr4:120376271 NA -1.03 -19.85 -0.74 1.79e-58 Height; LUSC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg27266027 chr21:40555129 PSMG1 -0.39 -5.77 -0.3 1.83e-8 Cognitive function; LUSC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg14895029 chr7:2775587 GNA12 -0.42 -6.42 -0.33 4.77e-10 Height; LUSC cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg08213375 chr14:104286397 PPP1R13B 0.53 10.51 0.5 1.69e-22 Schizophrenia; LUSC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg04546413 chr19:29218101 NA 0.71 11.42 0.53 1.02e-25 Methadone dose in opioid dependence; LUSC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg13556452 chr1:2391241 NA -0.34 -6.2 -0.32 1.68e-9 Schizophrenia; LUSC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg20744362 chr22:50050164 C22orf34 0.4 8.21 0.41 4.86e-15 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg08219700 chr8:58056026 NA 0.47 6.27 0.32 1.1e-9 Developmental language disorder (linguistic errors); LUSC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg07777115 chr5:623756 CEP72 -0.48 -5.88 -0.31 1.02e-8 Lung disease severity in cystic fibrosis; LUSC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs13089785 1.000 rs34246651 chr3:123664105 T/C cg02558132 chr3:123411198 MYLK 0.34 5.7 0.3 2.7e-8 Intelligence (multi-trait analysis); LUSC cis rs8072100 0.666 rs9913503 chr17:45776330 T/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.39 -6.08 -0.32 3.33e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs290268 1.000 rs290274 chr9:93546913 C/T cg02608019 chr9:93564028 SYK 0.53 8.92 0.44 3.11e-17 Platelet count; LUSC trans rs62238980 0.614 rs78354020 chr22:32394259 A/G cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs7923609 1.000 rs4595427 chr10:65012944 A/C cg01631684 chr10:65280961 REEP3 -0.42 -6.55 -0.34 2.14e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.88 0.4 4.78e-14 Prudent dietary pattern; LUSC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg17294928 chr15:75287854 SCAMP5 -0.82 -10.91 -0.51 6.64e-24 Blood trace element (Zn levels); LUSC cis rs1371867 0.775 rs6511 chr8:101252680 T/C cg06636551 chr8:101224915 SPAG1 0.38 7.06 0.36 9.56e-12 Atrioventricular conduction; LUSC cis rs12971120 0.685 rs34780792 chr18:72173278 G/A cg25817165 chr18:72167213 CNDP2 -0.74 -9.03 -0.44 1.42e-17 Refractive error; LUSC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg18512352 chr11:47633146 NA -0.46 -9.42 -0.46 7.43e-19 Subjective well-being; LUSC cis rs1549118 0.595 rs17106478 chr14:78328310 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.42 5.69 0.3 2.8e-8 Resting heart rate; LUSC cis rs7789940 0.904 rs73140040 chr7:75936240 C/T cg10167463 chr7:75959203 YWHAG -0.59 -8.6 -0.43 3.22e-16 Multiple sclerosis; LUSC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg16325326 chr1:53192061 ZYG11B 0.96 19.94 0.74 7.76e-59 Monocyte count; LUSC trans rs12692738 0.526 rs355848 chr2:165625277 T/C cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10498514 1.000 rs76202452 chr14:65027352 C/G cg25134081 chr14:64931936 AKAP5 0.81 6.03 0.31 4.25e-9 Cognitive performance; LUSC cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg18132916 chr6:79620363 NA -0.39 -5.94 -0.31 7.08e-9 Intelligence (multi-trait analysis); LUSC cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg01849466 chr14:104193079 ZFYVE21 0.57 8.93 0.44 2.83e-17 Schizophrenia; LUSC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.56 0.42 4.3e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs9467773 1.000 rs9467778 chr6:26534743 T/C cg09904177 chr6:26538194 HMGN4 0.76 14.42 0.62 5.75e-37 Intelligence (multi-trait analysis); LUSC trans rs4927850 0.881 rs7624638 chr3:195748729 C/T cg16724585 chr3:197361211 NA -0.58 -8.18 -0.41 6.01e-15 Pancreatic cancer; LUSC cis rs1395 0.922 rs13404446 chr2:27519254 C/T cg23587288 chr2:27483067 SLC30A3 -0.3 -5.87 -0.31 1.02e-8 Blood metabolite levels; LUSC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg07716408 chr11:68623521 NA 0.33 6.54 0.34 2.28e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs2797160 1.000 rs1777195 chr6:126006861 A/C cg05039488 chr6:79577232 IRAK1BP1 0.43 6.43 0.33 4.51e-10 Endometrial cancer; LUSC cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.34 -0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6961069 0.743 rs3211870 chr7:80287209 C/T cg04458919 chr7:80252533 CD36 -0.33 -5.99 -0.31 5.52e-9 Platelet count; LUSC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg05855489 chr10:104503620 C10orf26 0.63 8.2 0.41 5.12e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg26513180 chr16:89883248 FANCA 0.9 17.56 0.69 2.29e-49 Vitiligo; LUSC cis rs9814567 0.806 rs1880375 chr3:134322163 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.33 -0.56 4.74e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1371867 0.846 rs2083499 chr8:101230534 T/A cg00191853 chr8:101177733 SPAG1 0.41 6.64 0.34 1.27e-10 Atrioventricular conduction; LUSC trans rs67340775 0.834 rs13218875 chr6:27884012 C/T cg01620082 chr3:125678407 NA -0.83 -7.33 -0.37 1.76e-12 Lung cancer in ever smokers; LUSC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg17971929 chr21:40555470 PSMG1 -0.69 -11.53 -0.53 4.06e-26 Cognitive function; LUSC cis rs6912958 0.781 rs2207146 chr6:88180641 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.87 -0.35 3.22e-11 Monocyte percentage of white cells; LUSC cis rs1124376 0.748 rs6771367 chr3:20160266 A/T cg05072819 chr3:20081367 KAT2B 0.57 6.59 0.34 1.76e-10 Bipolar disorder and schizophrenia; LUSC trans rs7939886 0.920 rs10501343 chr11:55759573 G/T cg03929089 chr4:120376271 NA 0.79 6.5 0.34 2.94e-10 Myopia (pathological); LUSC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg02873098 chr16:4524103 NMRAL1;HMOX2 0.47 6.99 0.36 1.53e-11 Schizophrenia; LUSC cis rs936229 0.690 rs2472299 chr15:75033400 C/T cg14664628 chr15:75095509 CSK 0.86 14.05 0.61 1.47e-35 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.44 0.33 4.12e-10 Menopause (age at onset); LUSC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg15744005 chr10:104629667 AS3MT -0.36 -7.41 -0.38 1.06e-12 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs6487679 1.000 rs6487679 chr12:9371332 C/T cg00504896 chr12:9437009 LOC642846 -0.45 -5.8 -0.3 1.55e-8 Non-alcoholic fatty liver disease histology (AST); LUSC cis rs9463078 0.505 rs2038556 chr6:44740568 A/G cg25276700 chr6:44698697 NA 0.3 6.33 0.33 7.67e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg00166722 chr3:10149974 C3orf24 0.62 8.71 0.43 1.38e-16 Alzheimer's disease; LUSC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg16423285 chr20:60520624 NA -0.47 -5.84 -0.3 1.22e-8 Body mass index; LUSC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg08847533 chr14:75593920 NEK9 -0.81 -14.57 -0.62 1.41e-37 Height; LUSC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4147929 0.532 rs757232 chr19:1075979 C/T cg26576206 chr19:1064938 ABCA7 -0.41 -5.77 -0.3 1.8e-8 Alzheimer's disease (late onset); LUSC cis rs11098499 0.743 rs10003567 chr4:120241674 C/T cg09307838 chr4:120376055 NA 0.69 10.49 0.5 1.93e-22 Corneal astigmatism; LUSC cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.88 0.31 9.9e-9 Rheumatoid arthritis; LUSC cis rs12908161 1.000 rs12912388 chr15:85344550 T/A cg17173187 chr15:85201210 NMB 0.48 8.9 0.44 3.51e-17 Schizophrenia; LUSC trans rs11098499 0.779 rs10857066 chr4:120286596 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs738322 0.753 rs2267372 chr22:38598234 A/G cg25457927 chr22:38595422 NA 0.49 10.59 0.5 8.35e-23 Cutaneous nevi; LUSC trans rs804280 0.518 rs34266352 chr8:11791462 G/A cg06636001 chr8:8085503 FLJ10661 0.55 8.15 0.41 7.55e-15 Myopia (pathological); LUSC cis rs1003719 0.667 rs3753073 chr21:38466615 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 9.39 0.46 9.98e-19 Eye color traits; LUSC cis rs9300255 0.722 rs10846515 chr12:123801672 T/G cg00376283 chr12:123451042 ABCB9 0.66 7.74 0.39 1.2e-13 Neutrophil percentage of white cells; LUSC cis rs727505 1.000 rs68007199 chr7:124491307 T/C cg23710748 chr7:124431027 NA -0.42 -7.47 -0.38 6.9e-13 Lewy body disease; LUSC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg04553112 chr3:125709451 NA -0.49 -5.86 -0.31 1.11e-8 Blood pressure (smoking interaction); LUSC cis rs9902453 0.967 rs7212741 chr17:28322941 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.78 0.43 8.65e-17 Coffee consumption (cups per day); LUSC cis rs2742234 0.541 rs7098236 chr10:43740508 T/C cg07801480 chr10:43725741 RASGEF1A -0.39 -5.88 -0.31 1.01e-8 Hirschsprung disease; LUSC cis rs59698941 0.943 rs67437142 chr5:132306722 T/C cg02081065 chr5:132209139 LEAP2 -0.61 -5.88 -0.31 9.99e-9 Apolipoprotein A-IV levels; LUSC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs3087591 0.960 rs2952976 chr17:29486152 G/A cg24425628 chr17:29625626 OMG;NF1 0.56 8.3 0.41 2.68e-15 Hip circumference; LUSC cis rs7819412 0.936 rs7814499 chr8:11040647 A/G cg21775007 chr8:11205619 TDH -0.52 -7.36 -0.37 1.43e-12 Triglycerides; LUSC cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg13010199 chr12:38710504 ALG10B 0.7 10.93 0.51 5.81e-24 Morning vs. evening chronotype; LUSC cis rs9650315 0.538 rs67159733 chr8:57208791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.64 7.8 0.39 7.83e-14 Height; LUSC cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.25 -0.37 2.96e-12 Menopause (age at onset); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg15409468 chr5:31532111 RNASEN;C5orf22 0.38 6.32 0.33 8.27e-10 Triglycerides; LUSC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg06636001 chr8:8085503 FLJ10661 -0.56 -8.24 -0.41 3.84e-15 Joint mobility (Beighton score); LUSC cis rs6545883 0.929 rs12612982 chr2:61747355 G/A cg15711740 chr2:61764176 XPO1 -0.49 -7.84 -0.39 6.08e-14 Tuberculosis; LUSC cis rs9388451 0.874 rs3734634 chr6:126111800 G/A cg05901451 chr6:126070800 HEY2 -0.94 -18.32 -0.71 2.25e-52 Brugada syndrome; LUSC cis rs9902453 0.791 rs3115090 chr17:28035014 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.31 0.53 2.56e-25 Coffee consumption (cups per day); LUSC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.16 15.5 0.65 3.26e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.36 6.68 0.34 9.92e-11 Monocyte percentage of white cells; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.54 -9.0 -0.44 1.71e-17 Lymphocyte counts; LUSC trans rs10506458 1.000 rs12580997 chr12:63433420 G/A cg22491629 chr6:157744540 C6orf35 -0.9 -10.67 -0.5 4.68e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs1355223 0.506 rs11032898 chr11:34870111 C/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -6.76 -0.35 6.01e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg26384229 chr12:38710491 ALG10B 0.92 15.67 0.65 7e-42 Bladder cancer; LUSC cis rs262150 0.851 rs2657326 chr7:158766262 C/T cg19418458 chr7:158789849 NA -0.5 -8.17 -0.41 6.45e-15 Facial morphology (factor 20); LUSC cis rs6696846 0.765 rs72757524 chr1:205086473 C/T cg21545522 chr1:205238299 TMCC2 0.46 8.53 0.42 5.08e-16 Red blood cell count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17675882 chr20:35374068 NDRG3 0.42 6.41 0.33 5.1e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg07606381 chr6:8435919 SLC35B3 0.72 12.17 0.55 1.89e-28 Motion sickness; LUSC cis rs2839186 0.749 rs62226488 chr21:47710517 C/T cg12379764 chr21:47803548 PCNT -0.42 -5.91 -0.31 8.56e-9 Testicular germ cell tumor; LUSC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg12257692 chr3:49977190 RBM6 0.24 6.52 0.34 2.6e-10 Body mass index; LUSC cis rs72781680 0.583 rs6731333 chr2:24113354 C/T cg08917208 chr2:24149416 ATAD2B 0.58 6.6 0.34 1.62e-10 Lymphocyte counts; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg25767906 chr1:53392781 SCP2 -0.5 -9.09 -0.45 8.88e-18 Monocyte count; LUSC cis rs3862435 0.764 rs2107435 chr15:90994633 T/C cg22089800 chr15:90895588 ZNF774 0.57 6.02 0.31 4.62e-9 Response to exercise (triglyceride level interaction); LUSC cis rs4975709 0.686 rs2307118 chr5:1881916 A/C cg15595755 chr5:1867978 NA 0.4 6.31 0.33 8.93e-10 Cardiovascular disease risk factors; LUSC cis rs6456156 0.586 rs12198816 chr6:167483546 G/A cg07741184 chr6:167504864 NA 0.43 7.49 0.38 6.4e-13 Primary biliary cholangitis; LUSC trans rs2074977 0.550 rs11085020 chr19:3446107 C/T cg08382705 chr11:45687319 CHST1 0.49 7.82 0.39 7.15e-14 Height; LUSC cis rs71403859 0.803 rs8063455 chr16:71599977 G/A cg08717414 chr16:71523259 ZNF19 -0.75 -8.16 -0.41 7.1e-15 Post bronchodilator FEV1; LUSC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.99 0.36 1.47e-11 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02396040 chr6:88117726 C6orf165 -0.48 -7.55 -0.38 4.23e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2692947 0.644 rs1168976 chr2:96813480 G/A cg23100626 chr2:96804247 ASTL 0.3 7.17 0.37 4.93e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg26513180 chr16:89883248 FANCA -0.55 -8.11 -0.41 9.65e-15 Vitiligo; LUSC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg11062466 chr8:58055876 NA 0.49 6.38 0.33 6.03e-10 Developmental language disorder (linguistic errors); LUSC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg08847533 chr14:75593920 NEK9 -0.83 -15.07 -0.64 1.67e-39 Height; LUSC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.11 -0.32 2.82e-9 Total body bone mineral density; LUSC trans rs7824557 0.628 rs6601580 chr8:11193736 T/G cg08975724 chr8:8085496 FLJ10661 0.41 5.95 0.31 6.75e-9 Retinal vascular caliber; LUSC cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg14844989 chr11:31128820 NA -0.39 -6.0 -0.31 5.2e-9 Red blood cell count; LUSC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 5.98 0.31 5.84e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1127311 0.846 rs61811388 chr1:154581231 G/C cg17218026 chr1:154582156 ADAR 0.55 9.75 0.47 6.47e-20 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7215564 0.908 rs34914062 chr17:78655909 C/T cg09596252 chr17:78655493 RPTOR 0.59 6.14 0.32 2.33e-9 Myopia (pathological); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg01663295 chr11:65837194 PACS1 0.49 6.74 0.35 6.76e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.75 -0.35 6.58e-11 Neuroticism; LUSC cis rs965469 1.000 rs6139103 chr20:3361140 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.71 -0.3 2.55e-8 IFN-related cytopenia; LUSC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg04234412 chr22:24373322 LOC391322 -0.84 -13.66 -0.6 4.64e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7580658 0.864 rs4150454 chr2:128038544 T/C cg09760422 chr2:128146352 NA -0.28 -5.89 -0.31 9.64e-9 Protein C levels; LUSC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.02 -0.4 1.76e-14 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg02569458 chr12:86230093 RASSF9 0.51 8.53 0.42 5.01e-16 Major depressive disorder; LUSC cis rs10779751 0.770 rs12075896 chr1:11200350 C/A cg08854313 chr1:11322531 MTOR -0.85 -12.85 -0.58 5.65e-31 Body mass index; LUSC cis rs7267979 0.934 rs2482913 chr20:25405086 T/A cg08601574 chr20:25228251 PYGB -0.43 -6.61 -0.34 1.53e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs17604090 0.529 rs2392128 chr7:29711139 A/G cg19413766 chr7:29689036 LOC646762 0.53 7.18 0.37 4.63e-12 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs738322 0.577 rs4820320 chr22:38572977 G/A cg17652424 chr22:38574118 PLA2G6 -0.32 -6.59 -0.34 1.68e-10 Cutaneous nevi; LUSC cis rs9486719 1.000 rs6923212 chr6:97061940 A/G cg06623918 chr6:96969491 KIAA0776 -0.77 -9.6 -0.47 1.98e-19 Migraine;Coronary artery disease; LUSC cis rs6503525 0.701 rs28618095 chr17:38109075 T/C cg17467752 chr17:38218738 THRA 0.42 5.68 0.3 2.88e-8 Asthma; LUSC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg04267008 chr7:1944627 MAD1L1 -0.58 -8.47 -0.42 7.9e-16 Bipolar disorder and schizophrenia; LUSC cis rs9788682 0.747 rs7183604 chr15:78899213 T/C cg24631222 chr15:78858424 CHRNA5 -0.69 -9.46 -0.46 5.59e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg13047869 chr3:10149882 C3orf24 0.56 7.73 0.39 1.24e-13 Alzheimer's disease; LUSC cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg05738196 chr6:26577821 NA -0.81 -16.51 -0.67 3.37e-45 Intelligence (multi-trait analysis); LUSC cis rs3126085 1.000 rs2338555 chr1:152309380 G/A cg26876637 chr1:152193138 HRNR -0.44 -5.67 -0.3 3.13e-8 Atopic dermatitis; LUSC trans rs1814175 0.645 rs28441045 chr11:50048971 C/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg26354017 chr1:205819088 PM20D1 -0.79 -13.84 -0.6 9.5e-35 Menarche (age at onset); LUSC cis rs2115630 1.000 rs4633690 chr15:85361960 C/T cg11189052 chr15:85197271 WDR73 -0.4 -5.79 -0.3 1.62e-8 P wave terminal force; LUSC cis rs3764021 1.000 rs7977720 chr12:9866349 C/T cg20894963 chr12:9885564 CLECL1 0.32 6.57 0.34 1.98e-10 Type 1 diabetes; LUSC cis rs6964587 0.839 rs13246743 chr7:91453945 G/T cg22709100 chr7:91322751 NA 0.47 6.9 0.35 2.61e-11 Breast cancer; LUSC trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg17470723 chr8:74884337 TCEB1 0.52 8.17 0.41 6.5e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg02580895 chr19:2754563 NA -0.46 -6.98 -0.36 1.57e-11 Total cholesterol levels; LUSC cis rs4953076 0.573 rs9973609 chr2:44450435 T/C cg04920474 chr2:44395004 PPM1B 0.62 7.91 0.4 3.76e-14 Height; LUSC trans rs12188164 0.930 rs72717440 chr5:449701 A/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.38 5.95 0.31 6.6e-9 Cystic fibrosis severity; LUSC cis rs4243830 1.000 rs10158949 chr1:6583701 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.89 -8.87 -0.44 4.58e-17 Body mass index; LUSC cis rs7949030 0.688 rs2849031 chr11:62365665 G/A cg22862634 chr11:62369728 EML3;MTA2 -0.59 -9.67 -0.47 1.2e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs433852 1.000 rs433852 chr19:49117104 C/T cg06530960 chr19:49140787 SEC1;DBP -0.72 -9.26 -0.45 2.53e-18 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs17685 0.753 rs9691174 chr7:75790405 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.49 -7.28 -0.37 2.48e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs1322512 0.917 rs2623938 chr6:153001870 A/T cg27316956 chr6:152958899 SYNE1 0.37 6.23 0.32 1.4e-9 Tonometry; LUSC cis rs6669072 0.739 rs3843305 chr1:91243376 G/A cg08895590 chr1:91227319 NA -0.39 -8.75 -0.43 1.09e-16 Cognitive function; LUSC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.2 -0.32 1.68e-9 Platelet count; LUSC trans rs2262909 0.962 rs425781 chr19:22229306 A/G cg05197062 chr11:11642011 GALNTL4 -0.56 -7.81 -0.39 7.34e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg18352616 chr4:3374830 RGS12 0.33 6.71 0.34 8.42e-11 Serum sulfate level; LUSC cis rs950169 0.723 rs17589320 chr15:84919996 C/A cg17173187 chr15:85201210 NMB 0.36 6.41 0.33 5.06e-10 Schizophrenia; LUSC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg22166914 chr1:53195759 ZYG11B 0.7 11.91 0.55 1.73e-27 Monocyte count; LUSC trans rs7824557 0.675 rs2736265 chr8:11186674 A/G cg15556689 chr8:8085844 FLJ10661 0.47 6.78 0.35 5.57e-11 Retinal vascular caliber; LUSC cis rs8078723 0.966 rs57968500 chr17:38145828 A/G cg17467752 chr17:38218738 THRA 0.77 12.5 0.56 1.14e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg09184832 chr6:79620586 NA -0.45 -7.38 -0.37 1.26e-12 Intelligence (multi-trait analysis); LUSC cis rs1691799 0.836 rs1168334 chr12:66760972 A/G cg16791601 chr12:66731901 HELB -0.68 -11.99 -0.55 8.92e-28 White blood cell count (basophil); LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.53 -7.1 -0.36 7.33e-12 Renal function-related traits (BUN); LUSC cis rs738322 0.772 rs9619724 chr22:38517880 T/G cg17652424 chr22:38574118 PLA2G6 -0.28 -5.76 -0.3 1.9e-8 Cutaneous nevi; LUSC cis rs7818345 0.512 rs4922029 chr8:19304533 G/A cg11303988 chr8:19266685 CSGALNACT1 0.37 6.72 0.35 7.95e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg22903471 chr2:27725779 GCKR -0.41 -6.82 -0.35 4.23e-11 Total body bone mineral density; LUSC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg12639453 chr1:2035780 PRKCZ -0.33 -7.07 -0.36 8.95e-12 Height; LUSC cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg22906224 chr7:99728672 NA 0.47 6.57 0.34 1.98e-10 Coronary artery disease; LUSC trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg17470723 chr8:74884337 TCEB1 -0.46 -7.05 -0.36 1.01e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs9747201 1.000 rs9747668 chr17:80161081 A/G cg18209359 chr17:80159595 CCDC57 -0.37 -6.28 -0.32 1.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg21573476 chr21:45109991 RRP1B -0.42 -6.66 -0.34 1.13e-10 Mean corpuscular volume; LUSC cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.61 9.29 0.45 1.97e-18 Menarche (age at onset); LUSC cis rs1127311 0.905 rs6702449 chr1:154583210 A/C cg17218026 chr1:154582156 ADAR 0.56 10.06 0.48 5.92e-21 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs73198271 0.700 rs10103282 chr8:8650757 T/G cg01851573 chr8:8652454 MFHAS1 0.53 8.57 0.42 3.77e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7804356 1.000 rs3801846 chr7:26828653 C/T cg03456212 chr7:26904342 SKAP2 -0.52 -6.16 -0.32 2.14e-9 Type 1 diabetes; LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg26338869 chr17:61819248 STRADA 0.42 6.07 0.32 3.4e-9 Prudent dietary pattern; LUSC cis rs6987853 0.966 rs2974349 chr8:42404040 A/G cg09913449 chr8:42400586 C8orf40 -0.47 -7.85 -0.39 5.87e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg18240062 chr17:79603768 NPLOC4 -0.69 -12.86 -0.58 4.98e-31 Eye color traits; LUSC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg13535736 chr9:111863775 C9orf5 -0.41 -6.67 -0.34 1.08e-10 Menarche (age at onset); LUSC cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs9522267 0.535 rs9522304 chr13:112237316 C/T cg10483660 chr13:112241077 NA -0.31 -5.68 -0.3 3e-8 Hepatitis; LUSC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 9.13 0.45 6.62e-18 Height; LUSC cis rs9796 0.727 rs61203391 chr15:41352912 C/G cg18705301 chr15:41695430 NDUFAF1 -0.47 -8.03 -0.4 1.73e-14 Menopause (age at onset); LUSC cis rs3087591 0.708 rs2525568 chr17:29675878 T/G cg24425628 chr17:29625626 OMG;NF1 0.47 7.0 0.36 1.44e-11 Hip circumference; LUSC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg18876405 chr7:65276391 NA -0.64 -11.14 -0.52 1.02e-24 Aortic root size; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg12016809 chr21:47604291 C21orf56 0.44 6.54 0.34 2.32e-10 Testicular germ cell tumor; LUSC cis rs6840360 0.571 rs28454076 chr4:152520083 G/T cg22705602 chr4:152727874 NA -0.33 -6.7 -0.34 9.13e-11 Intelligence (multi-trait analysis); LUSC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg26441486 chr22:50317300 CRELD2 0.47 6.96 0.36 1.82e-11 Schizophrenia; LUSC cis rs1728785 0.901 rs12929568 chr16:68596689 A/G cg02972257 chr16:68554789 NA -0.48 -6.23 -0.32 1.4e-9 Ulcerative colitis; LUSC cis rs4664308 1.000 rs6759924 chr2:160912747 G/A cg03641300 chr2:160917029 PLA2R1 -0.67 -10.93 -0.51 5.76e-24 Idiopathic membranous nephropathy; LUSC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg22823121 chr1:150693482 HORMAD1 0.46 6.6 0.34 1.64e-10 Melanoma; LUSC cis rs12532214 0.617 rs73673328 chr7:3149140 G/C cg19214707 chr7:3157722 NA -0.44 -7.02 -0.36 1.21e-11 Itch intensity from mosquito bite; LUSC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02475777 chr4:1388615 CRIPAK -0.49 -7.33 -0.37 1.71e-12 Longevity; LUSC cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg11266682 chr4:10021025 SLC2A9 -0.52 -9.65 -0.47 1.4e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.78 0.3 1.71e-8 Rheumatoid arthritis; LUSC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg13798912 chr7:905769 UNC84A -0.58 -5.83 -0.3 1.29e-8 Cerebrospinal P-tau181p levels; LUSC cis rs2607426 0.681 rs2607413 chr19:41268214 C/T cg05508168 chr19:41255947 C19orf54;SNRPA 0.85 6.72 0.35 7.9e-11 Blood protein levels; LUSC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg06740227 chr12:86229804 RASSF9 0.39 6.09 0.32 3.05e-9 Major depressive disorder; LUSC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg18681998 chr4:17616180 MED28 0.88 17.17 0.68 8.26e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1113500 0.836 rs1122158 chr1:108588668 G/T cg11967332 chr1:108735228 SLC25A24 0.39 5.89 0.31 9.26e-9 Growth-regulated protein alpha levels; LUSC cis rs4363385 0.818 rs3795382 chr1:153004853 C/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.42e-12 Inflammatory skin disease; LUSC cis rs2882667 0.537 rs7701338 chr5:138405994 C/T cg04439458 chr5:138467593 SIL1 -0.34 -6.84 -0.35 3.75e-11 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg09365446 chr1:150670422 GOLPH3L 0.46 6.88 0.35 3.01e-11 Melanoma; LUSC cis rs2386661 0.603 rs11259704 chr10:5646999 C/T cg17085576 chr10:5658249 NA -0.44 -6.8 -0.35 4.95e-11 Breast cancer; LUSC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg00814883 chr7:100076585 TSC22D4 -0.73 -9.85 -0.47 2.85e-20 Platelet count; LUSC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg02187348 chr16:89574699 SPG7 0.52 7.11 0.36 7.26e-12 Multiple myeloma (IgH translocation); LUSC cis rs17255340 0.539 rs1144191 chr6:83981512 C/T cg08257003 chr6:84140564 ME1 0.32 7.68 0.39 1.76e-13 Platelet-derived growth factor BB levels; LUSC cis rs76878669 0.561 rs4930362 chr11:66154360 T/C cg18002602 chr11:66138449 SLC29A2 0.46 8.27 0.41 3.17e-15 Educational attainment (years of education); LUSC cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.69 -0.6 3.55e-34 Chronic sinus infection; LUSC cis rs7904368 0.806 rs7099178 chr10:16862578 C/G cg23933602 chr10:16859644 RSU1 0.51 6.19 0.32 1.74e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs7809950 0.678 rs7788271 chr7:106985873 A/G cg23024343 chr7:107201750 COG5 -0.66 -9.9 -0.48 1.99e-20 Coronary artery disease; LUSC cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg04455712 chr21:45112962 RRP1B 0.43 8.34 0.42 1.95e-15 Mean corpuscular volume; LUSC cis rs1865760 0.865 rs9467648 chr6:25957933 T/A cg17691542 chr6:26056736 HIST1H1C 0.46 6.88 0.35 3.01e-11 Height; LUSC cis rs2730245 1.000 rs2252502 chr7:158738634 G/C cg14689365 chr7:158441557 NCAPG2 -0.45 -6.13 -0.32 2.46e-9 Height; LUSC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6121246 0.738 rs6121242 chr20:30410877 T/C cg13852791 chr20:30311386 BCL2L1 0.81 10.64 0.5 5.76e-23 Mean corpuscular hemoglobin; LUSC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.46 -0.33 3.71e-10 Menopause (age at onset); LUSC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg20203395 chr5:56204925 C5orf35 -0.73 -9.94 -0.48 1.45e-20 Initial pursuit acceleration; LUSC cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg27432699 chr2:27873401 GPN1 -0.59 -8.84 -0.44 5.7e-17 Total body bone mineral density; LUSC cis rs3733631 0.948 rs28438896 chr4:104625753 C/T cg24090629 chr4:104641072 TACR3 -0.45 -5.68 -0.3 2.93e-8 Menarche (age at onset); LUSC cis rs73206853 0.563 rs73194051 chr12:111204186 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 6.98 0.36 1.55e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg15485101 chr11:133734466 NA 0.43 7.61 0.38 2.87e-13 Childhood ear infection; LUSC cis rs7296418 0.580 rs78455769 chr12:123856443 G/A cg00376283 chr12:123451042 ABCB9 0.71 10.79 0.51 1.74e-23 Platelet count; LUSC cis rs3858526 0.834 rs10838989 chr11:5978057 A/G cg13902645 chr11:5959945 NA -0.61 -8.48 -0.42 7.35e-16 DNA methylation (variation); LUSC cis rs6835098 1.000 rs6814857 chr4:174082805 T/A cg27433088 chr4:174089019 GALNT7 0.39 5.64 0.3 3.55e-8 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg14552801 chr7:65878734 NA 0.38 5.9 0.31 8.97e-9 Aortic root size; LUSC cis rs1538970 0.962 rs9429077 chr1:45820667 C/A cg06784218 chr1:46089804 CCDC17 0.32 5.9 0.31 9.08e-9 Platelet count; LUSC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.87e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs7592578 0.771 rs4258824 chr2:191395027 C/T cg10560079 chr2:191398806 TMEM194B -0.71 -8.69 -0.43 1.7e-16 Diastolic blood pressure; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17597744 chr8:53627099 RB1CC1 -0.49 -6.35 -0.33 7.16e-10 Bipolar disorder and schizophrenia; LUSC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg22862634 chr11:62369728 EML3;MTA2 0.59 9.33 0.45 1.46e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg05738196 chr6:26577821 NA 0.46 6.74 0.35 7.09e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs295140 0.706 rs3769483 chr2:201173048 A/G cg04283868 chr2:201171347 SPATS2L 0.43 6.18 0.32 1.82e-9 QT interval; LUSC cis rs7584330 0.868 rs7569197 chr2:238383073 A/G cg16989719 chr2:238392110 NA -0.36 -5.9 -0.31 9.01e-9 Prostate cancer; LUSC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg18681998 chr4:17616180 MED28 0.85 15.29 0.64 2.17e-40 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs17270561 0.609 rs9356986 chr6:25739119 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.51 0.38 5.48e-13 Iron status biomarkers; LUSC cis rs7845219 0.539 rs10441538 chr8:95868608 G/A cg09323728 chr8:95962352 TP53INP1 -0.36 -7.42 -0.38 9.69e-13 Type 2 diabetes; LUSC cis rs1670533 0.932 rs9992925 chr4:1050909 A/T cg27284194 chr4:1044797 NA 0.57 8.42 0.42 1.12e-15 Recombination rate (females); LUSC cis rs778371 0.697 rs11893358 chr2:233636922 T/C cg08000102 chr2:233561755 GIGYF2 0.8 13.48 0.59 2.37e-33 Schizophrenia; LUSC cis rs897080 0.516 rs1067361 chr2:44661217 G/C cg00619915 chr2:44497795 NA -0.41 -6.02 -0.31 4.5e-9 Height; LUSC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg22166914 chr1:53195759 ZYG11B 0.67 11.81 0.54 3.87e-27 Monocyte count; LUSC cis rs7829975 0.714 rs4840362 chr8:8670082 C/G cg15556689 chr8:8085844 FLJ10661 -0.65 -10.48 -0.5 2.06e-22 Mood instability; LUSC cis rs7577696 0.962 rs17767988 chr2:32286826 G/A cg02381751 chr2:32503542 YIPF4 -0.39 -5.66 -0.3 3.3e-8 Inflammatory biomarkers; LUSC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg02018176 chr4:1364513 KIAA1530 0.52 8.87 0.44 4.63e-17 Obesity-related traits; LUSC cis rs2898681 0.561 rs58577680 chr4:53734294 C/T cg21521518 chr4:53727714 RASL11B 0.44 5.84 0.3 1.27e-8 Optic nerve measurement (cup area); LUSC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.86 0.35 3.34e-11 Intelligence (multi-trait analysis); LUSC trans rs61931739 0.556 rs7954221 chr12:33825077 C/T cg26384229 chr12:38710491 ALG10B 0.45 7.28 0.37 2.4e-12 Morning vs. evening chronotype; LUSC trans rs7824557 0.628 rs6988922 chr8:11194911 A/G cg08975724 chr8:8085496 FLJ10661 0.42 6.12 0.32 2.62e-9 Retinal vascular caliber; LUSC cis rs13256369 0.851 rs13266562 chr8:8564065 T/C cg06671706 chr8:8559999 CLDN23 0.49 6.61 0.34 1.48e-10 Obesity-related traits; LUSC cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg08999081 chr20:33150536 PIGU -0.53 -10.53 -0.5 1.36e-22 Glomerular filtration rate (creatinine); LUSC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg22834771 chr12:69754056 YEATS4 -0.41 -5.84 -0.3 1.25e-8 Blood protein levels; LUSC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg05738196 chr6:26577821 NA 0.47 6.8 0.35 4.7e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9309473 1.000 rs6745368 chr2:73809974 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.67 -0.34 1.05e-10 Metabolite levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16785698 chr4:186456103 PDLIM3 0.44 7.09 0.36 7.96e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg24642439 chr20:33292090 TP53INP2 0.73 11.98 0.55 9.08e-28 Coronary artery disease; LUSC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg04450456 chr4:17643702 FAM184B 0.42 7.06 0.36 9.89e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg27494647 chr7:150038898 RARRES2 0.58 8.48 0.42 7.55e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.12e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg23711669 chr6:146136114 FBXO30 -0.77 -12.37 -0.56 3.54e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg23281280 chr6:28129359 ZNF389 0.45 5.86 0.31 1.14e-8 Parkinson's disease; LUSC cis rs1595825 0.891 rs1440086 chr2:198906354 A/G cg10547527 chr2:198650123 BOLL -0.52 -6.31 -0.33 8.84e-10 Ulcerative colitis; LUSC trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg03929089 chr4:120376271 NA -0.45 -6.18 -0.32 1.92e-9 HDL cholesterol; LUSC cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs9462027 0.606 rs6906129 chr6:34801160 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -6.03 -0.31 4.4e-9 Systemic lupus erythematosus; LUSC cis rs12893668 0.703 rs8017993 chr14:104047734 A/G cg08213375 chr14:104286397 PPP1R13B 0.36 6.12 0.32 2.58e-9 Reticulocyte count; LUSC cis rs208520 0.706 rs851601 chr6:66893853 G/A cg07460842 chr6:66804631 NA -1.06 -15.98 -0.66 4.32e-43 Exhaled nitric oxide output; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03576123 chr11:487126 PTDSS2 -0.95 -10.57 -0.5 9.88e-23 Body mass index; LUSC trans rs2587949 0.615 rs1485269 chr3:4222976 C/T cg15139668 chr4:4577005 NA 0.41 6.13 0.32 2.44e-9 Periodontitis (DPAL); LUSC cis rs9650657 0.770 rs6601529 chr8:10670550 A/G cg27411982 chr8:10470053 RP1L1 -0.37 -6.21 -0.32 1.59e-9 Neuroticism; LUSC cis rs1044826 0.692 rs176987 chr3:139233001 G/A cg15131784 chr3:139108705 COPB2 -0.39 -6.31 -0.33 8.61e-10 Obesity-related traits; LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg06387496 chr7:2775674 GNA12 0.37 5.9 0.31 8.73e-9 Height; LUSC cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg02891314 chr5:179741120 GFPT2 -0.65 -10.65 -0.5 5.3e-23 Height; LUSC cis rs17621444 0.522 rs67595246 chr10:121812443 C/G cg02041677 chr10:121771263 NA -0.33 -6.34 -0.33 7.26e-10 IgG glycosylation; LUSC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg17294928 chr15:75287854 SCAMP5 -0.93 -13.63 -0.6 6.13e-34 Blood trace element (Zn levels); LUSC cis rs2346177 0.580 rs1530628 chr2:46670941 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.63 -10.09 -0.48 4.54e-21 HDL cholesterol; LUSC cis rs68170813 0.559 rs3801959 chr7:106955666 A/G cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC cis rs11785400 0.793 rs13255558 chr8:143748080 C/T cg10596483 chr8:143751796 JRK 0.52 7.38 0.37 1.3e-12 Schizophrenia; LUSC cis rs55871839 0.708 rs13263261 chr8:59814688 T/G cg07426533 chr8:59803705 TOX -0.36 -5.8 -0.3 1.57e-8 Pneumonia; LUSC cis rs6964587 0.869 rs6964050 chr7:91482418 C/T cg17063962 chr7:91808500 NA -0.52 -8.03 -0.4 1.64e-14 Breast cancer; LUSC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg00800038 chr16:89945340 TCF25 -0.66 -6.82 -0.35 4.41e-11 Skin colour saturation; LUSC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg07936489 chr17:37558343 FBXL20 0.72 9.92 0.48 1.64e-20 Glomerular filtration rate (creatinine); LUSC cis rs4718428 1.000 rs12534637 chr7:66327654 G/C cg18252515 chr7:66147081 NA -0.42 -6.36 -0.33 6.48e-10 Corneal structure; LUSC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg19418458 chr7:158789849 NA -0.52 -8.28 -0.41 2.95e-15 Facial morphology (factor 20); LUSC cis rs1160297 0.585 rs4143203 chr2:53035763 C/T cg07782112 chr2:53107842 NA 0.42 6.54 0.34 2.34e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg18132916 chr6:79620363 NA -0.39 -6.02 -0.31 4.69e-9 Intelligence (multi-trait analysis); LUSC cis rs7617773 0.744 rs2125482 chr3:48323133 T/G cg20734569 chr3:48348370 SPINK8 -0.48 -8.3 -0.41 2.64e-15 Coronary artery disease; LUSC cis rs2219968 0.798 rs4739185 chr8:78879189 A/G cg00738934 chr8:78996279 NA -0.39 -6.85 -0.35 3.54e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs7927592 0.913 rs6591344 chr11:68360873 G/A cg20283391 chr11:68216788 NA -0.61 -8.42 -0.42 1.15e-15 Total body bone mineral density; LUSC cis rs11583043 0.874 rs6577219 chr1:101415707 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.3 0.33 9.14e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg12011299 chr4:100065546 ADH4 -0.71 -13.02 -0.58 1.25e-31 Alcohol dependence; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg23034840 chr1:205782522 SLC41A1 0.59 8.38 0.42 1.52e-15 Menarche (age at onset); LUSC cis rs12579753 0.917 rs12311988 chr12:82177209 C/A cg21231944 chr12:82153410 PPFIA2 -0.38 -5.83 -0.3 1.32e-8 Resting heart rate; LUSC cis rs11122272 0.735 rs2572249 chr1:231514829 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.85 -0.47 2.99e-20 Hemoglobin concentration; LUSC cis rs595982 0.559 rs17206714 chr19:49362001 T/A cg15549821 chr19:49342101 PLEKHA4 -0.61 -8.29 -0.41 2.89e-15 Red cell distribution width; LUSC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -6.51 -0.34 2.82e-10 Developmental language disorder (linguistic errors); LUSC cis rs16910800 0.953 rs73481419 chr11:23204953 A/G cg20040320 chr11:23191996 NA -0.44 -6.46 -0.33 3.8e-10 Cancer; LUSC cis rs9463078 0.764 rs6923519 chr6:44864152 A/G cg25276700 chr6:44698697 NA -0.28 -5.65 -0.3 3.51e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg23422044 chr7:1970798 MAD1L1 -0.56 -6.15 -0.32 2.18e-9 Bipolar disorder; LUSC cis rs9611519 0.828 rs4822008 chr22:41539206 C/G cg03806693 chr22:41940476 POLR3H -0.54 -7.5 -0.38 5.79e-13 Neuroticism; LUSC cis rs9611565 0.525 rs9611548 chr22:41704143 G/T cg03806693 chr22:41940476 POLR3H -0.63 -9.05 -0.44 1.18e-17 Vitiligo; LUSC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg24531977 chr5:56204891 C5orf35 -1.07 -15.83 -0.65 1.64e-42 Initial pursuit acceleration; LUSC cis rs2290416 0.892 rs62522168 chr8:144679776 G/A cg08017634 chr8:144659831 NAPRT1 0.72 6.17 0.32 2.03e-9 Attention deficit hyperactivity disorder; LUSC cis rs3772130 0.962 rs11721291 chr3:121563285 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.69 9.98 0.48 1.09e-20 Cognitive performance; LUSC cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg26446133 chr18:72167187 CNDP2 -0.85 -13.41 -0.59 4.32e-33 Refractive error; LUSC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.61 9.14 0.45 6.02e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs250677 1.000 rs36082 chr5:148428844 C/G cg12140854 chr5:148520817 ABLIM3 -0.39 -6.13 -0.32 2.51e-9 Breast cancer; LUSC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg22875332 chr1:76189707 ACADM 0.82 14.39 0.62 7.5e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg25566285 chr7:158114605 PTPRN2 0.31 5.85 0.3 1.2e-8 Calcium levels; LUSC cis rs738322 0.511 rs2267370 chr22:38576826 G/A cg17652424 chr22:38574118 PLA2G6 -0.3 -5.84 -0.3 1.27e-8 Cutaneous nevi; LUSC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg00745463 chr17:30367425 LRRC37B -0.79 -9.11 -0.45 7.81e-18 Hip circumference adjusted for BMI; LUSC cis rs11030122 0.673 rs10767767 chr11:4003678 C/T cg08557956 chr11:4115526 RRM1 -0.45 -5.97 -0.31 5.96e-9 Mean platelet volume;Platelet distribution width; LUSC trans rs7939886 0.920 rs7112964 chr11:55866408 T/C cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -7.89 -0.4 4.39e-14 Longevity;Endometriosis; LUSC cis rs9443645 0.527 rs9343870 chr6:79789473 T/G cg23262351 chr6:79576851 IRAK1BP1 -0.37 -5.7 -0.3 2.64e-8 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg20503657 chr10:835505 NA 1.19 16.28 0.67 2.87e-44 Eosinophil percentage of granulocytes; LUSC cis rs7523050 0.643 rs12736534 chr1:109399934 T/C cg08274380 chr1:109419600 GPSM2 1.1 10.69 0.51 3.76e-23 Fat distribution (HIV); LUSC cis rs483180 0.855 rs562038 chr1:120254545 G/C cg19096424 chr1:120255104 PHGDH 0.59 8.36 0.42 1.71e-15 Macular telangiectasia type 2; LUSC trans rs2228479 0.681 rs11641790 chr16:89961957 A/G cg24644049 chr4:85504048 CDS1 -0.69 -6.97 -0.36 1.68e-11 Skin colour saturation; LUSC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg26335602 chr6:28129616 ZNF389 0.43 5.78 0.3 1.7e-8 Parkinson's disease; LUSC cis rs12908161 0.959 rs2175567 chr15:85200946 C/G cg12863693 chr15:85201151 NMB 0.39 8.17 0.41 6.62e-15 Schizophrenia; LUSC cis rs59918340 0.509 rs11784862 chr8:142203452 T/C cg23750338 chr8:142222470 SLC45A4 0.45 8.22 0.41 4.47e-15 Immature fraction of reticulocytes; LUSC cis rs16854884 0.837 rs7644767 chr3:143803092 C/G cg06585982 chr3:143692056 C3orf58 0.43 6.42 0.33 4.8e-10 Economic and political preferences (feminism/equality); LUSC cis rs3087591 1.000 rs2905800 chr17:29531980 A/G cg24425628 chr17:29625626 OMG;NF1 0.55 8.0 0.4 2.11e-14 Hip circumference; LUSC cis rs6545883 0.965 rs2305155 chr2:61729258 A/G cg15711740 chr2:61764176 XPO1 -0.47 -7.6 -0.38 2.97e-13 Tuberculosis; LUSC cis rs6460942 0.732 rs73677576 chr7:12286535 G/A cg06484146 chr7:12443880 VWDE -0.58 -6.11 -0.32 2.71e-9 Coronary artery disease; LUSC cis rs7766436 0.885 rs13199041 chr6:22577718 A/G cg13666174 chr6:22585274 NA -0.41 -5.73 -0.3 2.29e-8 Coronary artery disease; LUSC cis rs7572644 0.699 rs10170872 chr2:28164553 C/T cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6964587 0.626 rs7785941 chr7:91531024 T/C cg17063962 chr7:91808500 NA -0.57 -9.44 -0.46 6.79e-19 Breast cancer; LUSC cis rs12765878 1.000 rs11191843 chr10:105648651 G/C cg11005552 chr10:105648138 OBFC1 0.36 5.65 0.3 3.38e-8 Coronary artery disease; LUSC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg18252515 chr7:66147081 NA 1.23 14.1 0.61 9.75e-36 Diabetic kidney disease; LUSC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg08045932 chr20:61659980 NA 0.58 10.07 0.48 5.3e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg21984481 chr17:79567631 NPLOC4 -0.55 -10.24 -0.49 1.39e-21 Eye color traits; LUSC cis rs7829975 0.572 rs7005000 chr8:8796602 A/G cg15556689 chr8:8085844 FLJ10661 -0.61 -10.11 -0.48 3.72e-21 Mood instability; LUSC cis rs9914988 0.943 rs4313850 chr17:27080768 T/C cg09479241 chr17:27052676 TLCD1 0.43 5.84 0.3 1.26e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7202877 0.656 rs9923834 chr16:75507253 T/A cg04384234 chr16:75411784 CFDP1 -0.62 -8.48 -0.42 7.33e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs950169 0.840 rs4842853 chr15:84942304 G/T cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.38 8.03 0.4 1.68e-14 Hemoglobin concentration; LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg11965913 chr1:205819406 PM20D1 0.51 7.61 0.38 2.81e-13 Prostate-specific antigen levels; LUSC cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg24692254 chr21:30365293 RNF160 -0.77 -13.77 -0.6 1.84e-34 Dental caries; LUSC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 6.58 0.34 1.85e-10 Personality dimensions; LUSC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg09640425 chr7:158790006 NA 0.51 8.39 0.42 1.44e-15 Facial morphology (factor 20); LUSC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.56 -7.46 -0.38 7.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7106204 0.534 rs56157310 chr11:24260694 A/G ch.11.24196551F chr11:24239977 NA 0.73 6.22 0.32 1.49e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg20135002 chr11:47629003 NA -0.5 -7.76 -0.39 1.05e-13 Subjective well-being; LUSC cis rs7291412 0.929 rs7289457 chr22:46456603 C/T cg23595222 chr22:46449430 C22orf26;LOC150381 0.37 5.93 0.31 7.49e-9 Dupuytren's disease;Subjective well-being; LUSC cis rs7523050 0.643 rs35907086 chr1:109406625 A/G cg08274380 chr1:109419600 GPSM2 1.12 10.7 0.51 3.48e-23 Fat distribution (HIV); LUSC cis rs12760731 0.720 rs12021983 chr1:178323800 C/T cg00404053 chr1:178313656 RASAL2 0.54 6.16 0.32 2.04e-9 Obesity-related traits; LUSC cis rs868036 1.000 rs1026736 chr15:68101813 T/C cg08079166 chr15:68083412 MAP2K5 0.4 8.28 0.41 3.04e-15 Restless legs syndrome; LUSC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg20811857 chr17:78079795 GAA -0.32 -5.94 -0.31 7.01e-9 Yeast infection; LUSC cis rs1712517 0.904 rs6584547 chr10:105065409 C/T cg05636881 chr10:105038444 INA 0.38 6.22 0.32 1.48e-9 Migraine; LUSC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg13770153 chr20:60521292 NA -0.64 -9.0 -0.44 1.69e-17 Body mass index; LUSC cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.09e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.89 -0.35 2.82e-11 Breast cancer; LUSC cis rs7577696 0.850 rs11124276 chr2:32318428 C/G cg02381751 chr2:32503542 YIPF4 -0.4 -5.74 -0.3 2.15e-8 Inflammatory biomarkers; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg22907277 chr7:1156413 C7orf50 0.51 7.72 0.39 1.36e-13 Longevity;Endometriosis; LUSC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg10018233 chr7:150070692 REPIN1 -0.38 -6.69 -0.34 9.37e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs595982 0.527 rs17272673 chr19:49362992 C/A cg15549821 chr19:49342101 PLEKHA4 -0.61 -8.34 -0.42 1.95e-15 Red cell distribution width; LUSC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg25019033 chr10:957182 NA -0.51 -5.69 -0.3 2.84e-8 Eosinophil percentage of granulocytes; LUSC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.45 -8.27 -0.41 3.29e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs1878931 0.507 rs11648783 chr16:3406626 A/G cg00484396 chr16:3507460 NAT15 -0.47 -7.11 -0.36 6.9e-12 Body mass index (adult); LUSC cis rs2762353 0.935 rs1185567 chr6:25818588 A/G cg03517284 chr6:25882590 NA -0.46 -8.19 -0.41 5.6e-15 Blood metabolite levels; LUSC trans rs6502050 0.871 rs6416857 chr17:80063004 A/G cg07393940 chr7:158741817 NA -0.37 -6.51 -0.34 2.81e-10 Life satisfaction; LUSC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.07 -0.32 3.48e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.8e-13 Schizophrenia; LUSC cis rs10419226 0.577 rs886443 chr19:18783785 A/G cg22001208 chr19:18782374 NA -0.38 -6.36 -0.33 6.69e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs61931739 0.500 rs7296061 chr12:34435009 A/G cg26384229 chr12:38710491 ALG10B -0.87 -14.94 -0.63 5.21e-39 Morning vs. evening chronotype; LUSC cis rs4443100 0.670 rs13056137 chr22:23407261 C/A cg21100191 chr22:23484243 RTDR1 0.56 7.0 0.36 1.37e-11 Serum parathyroid hormone levels; LUSC cis rs12541635 0.801 rs12155858 chr8:107105205 G/A cg10147462 chr8:107024639 NA -0.45 -7.99 -0.4 2.18e-14 Age of smoking initiation; LUSC trans rs7613875 0.600 rs2624826 chr3:50155468 T/G cg21659725 chr3:3221576 CRBN -0.54 -8.38 -0.42 1.46e-15 Body mass index; LUSC cis rs11048434 0.761 rs2110190 chr12:9128289 A/C cg13575925 chr12:9217583 LOC144571 0.34 6.12 0.32 2.63e-9 Sjögren's syndrome; LUSC trans rs877282 0.945 rs12767287 chr10:787310 A/G cg22713356 chr15:30763199 NA 1.09 15.49 0.65 3.65e-41 Uric acid levels; LUSC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.81 -0.35 4.59e-11 Lung cancer; LUSC cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs8060686 0.641 rs113790673 chr16:68244347 C/T cg09835421 chr16:68378352 PRMT7 -0.55 -5.98 -0.31 5.84e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs748404 0.578 rs573615 chr15:43614281 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.6 9.23 0.45 3.31e-18 Lung cancer; LUSC cis rs908922 0.676 rs11205031 chr1:152527662 C/T cg20991723 chr1:152506922 NA 0.51 9.59 0.46 2.12e-19 Hair morphology; LUSC cis rs6494488 0.500 rs112698132 chr15:64906413 C/T cg08069370 chr15:64387884 SNX1 -0.65 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs1577917 0.739 rs9450318 chr6:86427177 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.52 8.31 0.41 2.41e-15 Response to antipsychotic treatment; LUSC cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg12564285 chr5:131593104 PDLIM4 0.37 6.64 0.34 1.28e-10 Blood metabolite levels; LUSC cis rs11105298 0.891 rs11105318 chr12:89926658 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.41 -0.38 1.07e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8180040 0.966 rs11711824 chr3:47468261 C/T cg02527881 chr3:46936655 PTH1R -0.38 -6.72 -0.35 7.84e-11 Colorectal cancer; LUSC cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg13256891 chr4:100009986 ADH5 0.46 6.32 0.33 8.54e-10 Alcohol dependence; LUSC cis rs1847202 0.859 rs4566476 chr3:72948995 G/C cg25664220 chr3:72788482 NA -0.41 -7.36 -0.37 1.44e-12 Motion sickness; LUSC cis rs9814567 0.752 rs6779294 chr3:134329821 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.52 -0.57 9.71e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg13319975 chr6:146136371 FBXO30 0.48 7.23 0.37 3.33e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg08736216 chr1:53307985 ZYG11A -0.28 -5.82 -0.3 1.38e-8 Monocyte count; LUSC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg10546459 chr2:36825355 FEZ2 -0.44 -6.25 -0.32 1.26e-9 Height; LUSC cis rs36093844 0.752 rs17817308 chr11:85593529 G/A cg25872744 chr11:85566296 CCDC83 -0.46 -6.04 -0.31 4.16e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg16545954 chr1:2118288 C1orf86 0.38 7.29 0.37 2.25e-12 Height; LUSC cis rs911555 0.692 rs7145753 chr14:103866100 G/A cg24130564 chr14:104152367 KLC1 0.45 6.36 0.33 6.71e-10 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg05855489 chr10:104503620 C10orf26 0.62 7.91 0.4 3.85e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9790314 1.000 rs9870059 chr3:161017240 T/C cg04691961 chr3:161091175 C3orf57 -0.34 -5.85 -0.3 1.18e-8 Morning vs. evening chronotype; LUSC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg23711669 chr6:146136114 FBXO30 0.78 12.84 0.57 6.16e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg13390004 chr1:15929781 NA 0.41 6.76 0.35 6.35e-11 Systolic blood pressure; LUSC cis rs601339 1.000 rs4759361 chr12:123178280 T/A cg11919336 chr12:123188078 GPR109A 0.42 6.28 0.32 1.07e-9 Adiponectin levels; LUSC cis rs243505 0.726 rs734005 chr7:148505864 G/A cg09806900 chr7:148480153 CUL1 0.59 8.56 0.42 4.16e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2404602 0.647 rs11633869 chr15:77133322 G/T cg23625390 chr15:77176239 SCAPER 0.63 9.85 0.47 2.92e-20 Blood metabolite levels; LUSC cis rs8141529 0.509 rs6005927 chr22:29255884 A/G cg02153584 chr22:29168773 CCDC117 0.55 8.07 0.4 1.31e-14 Lymphocyte counts; LUSC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Parkinson's disease; LUSC cis rs6982240 0.514 rs10089212 chr8:142265380 T/A cg00131261 chr8:142287264 NA -0.37 -6.11 -0.32 2.8e-9 Tonsillectomy; LUSC cis rs9638182 0.666 rs2286276 chr7:72987354 C/T cg07452164 chr7:72993570 TBL2 0.45 6.33 0.33 7.91e-10 Triglycerides; LUSC cis rs2070488 0.775 rs2186457 chr3:38553965 A/G cg24069376 chr3:38537580 EXOG 0.36 7.0 0.36 1.43e-11 Electrocardiographic conduction measures; LUSC trans rs10435719 0.902 rs11250179 chr8:11800332 C/T cg06636001 chr8:8085503 FLJ10661 0.53 7.97 0.4 2.54e-14 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg05855489 chr10:104503620 C10orf26 0.55 8.26 0.41 3.39e-15 Arsenic metabolism; LUSC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg13867718 chr16:29973267 TMEM219 0.57 7.46 0.38 7.5e-13 Cognitive function;Information processing speed; LUSC cis rs9653442 0.564 rs10185510 chr2:100790581 C/T cg22139774 chr2:100720529 AFF3 -0.41 -7.13 -0.36 6.27e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs2736345 0.788 rs998683 chr8:11353000 A/G cg08224773 chr8:11311868 FAM167A -0.32 -5.64 -0.3 3.57e-8 Sjögren's syndrome;Systemic lupus erythematosus; LUSC cis rs1595825 0.891 rs73054808 chr2:198602283 C/T cg19156104 chr2:198669113 PLCL1 -0.47 -5.68 -0.3 2.88e-8 Ulcerative colitis; LUSC cis rs10197940 0.662 rs1047957 chr2:152333773 C/T cg06191203 chr2:152266755 RIF1 -0.53 -7.3 -0.37 2.17e-12 Lung cancer; LUSC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs1577917 0.739 rs9344532 chr6:86234070 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.52 8.13 0.41 8.33e-15 Response to antipsychotic treatment; LUSC cis rs9309473 0.500 rs10865398 chr2:73741497 A/C cg20560298 chr2:73613845 ALMS1 0.47 7.33 0.37 1.76e-12 Metabolite levels; LUSC cis rs10542411 1 rs10542411 chr2:61768239 ATATAT/A cg15711740 chr2:61764176 XPO1 -0.49 -7.56 -0.38 4.03e-13 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9814567 1.000 rs10804632 chr3:134294501 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.55 -0.6 1.2e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7202877 0.519 rs4887811 chr16:75307251 C/T cg03315344 chr16:75512273 CHST6 0.43 6.54 0.34 2.29e-10 Type 2 diabetes;Type 1 diabetes; LUSC trans rs853679 0.546 rs200490 chr6:27796935 G/T cg01620082 chr3:125678407 NA -0.68 -6.86 -0.35 3.42e-11 Depression; LUSC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.57 7.36 0.37 1.48e-12 Age-related macular degeneration (geographic atrophy); LUSC trans rs7937682 0.883 rs1789358 chr11:111474116 G/A cg18187862 chr3:45730750 SACM1L 0.52 6.64 0.34 1.29e-10 Primary sclerosing cholangitis; LUSC cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg13126279 chr21:47581558 C21orf56 -0.42 -6.16 -0.32 2.08e-9 Testicular germ cell tumor; LUSC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg03929089 chr4:120376271 NA -0.93 -15.94 -0.66 6.07e-43 Height; LUSC cis rs1534166 0.647 rs9876158 chr3:133508300 T/C cg01448562 chr3:133502909 NA 0.59 9.19 0.45 4.24e-18 Alcohol consumption (transferrin glycosylation); LUSC cis rs9815354 1.000 rs73069392 chr3:41787009 C/T cg03022575 chr3:42003672 ULK4 0.64 6.86 0.35 3.44e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg20203395 chr5:56204925 C5orf35 -0.75 -8.37 -0.42 1.58e-15 Type 2 diabetes; LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg10802521 chr3:52805072 NEK4 -0.57 -8.96 -0.44 2.39e-17 Bipolar disorder; LUSC cis rs78366141 0.536 rs76806573 chr4:89682729 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.93 7.35 0.37 1.53e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 0.39 6.73 0.35 7.62e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs10506458 0.915 rs998505 chr12:63400018 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.8 -0.65 2.22e-42 Hemostatic factors and hematological phenotypes; LUSC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg13939156 chr17:80058883 NA 0.33 6.42 0.33 4.73e-10 Life satisfaction; LUSC cis rs5769765 0.908 rs138864 chr22:50204712 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.43 6.36 0.33 6.59e-10 Schizophrenia; LUSC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg20203395 chr5:56204925 C5orf35 -0.78 -10.56 -0.5 1.09e-22 Initial pursuit acceleration; LUSC cis rs9796 0.866 rs66818965 chr15:41402279 G/A cg18705301 chr15:41695430 NDUFAF1 -0.46 -8.04 -0.4 1.55e-14 Menopause (age at onset); LUSC cis rs3741151 1.000 rs74749711 chr11:73052839 A/T cg17517138 chr11:73019481 ARHGEF17 0.91 8.2 0.41 5.22e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg13175981 chr1:150552382 MCL1 -0.41 -5.67 -0.3 3.17e-8 Tonsillectomy; LUSC trans rs445114 0.527 rs606677 chr8:128334485 T/C cg10897648 chr18:56338258 MALT1 -0.41 -6.23 -0.32 1.4e-9 Prostate cancer;Prostate cancer (SNP x SNP interaction); LUSC cis rs17685 0.712 rs11764119 chr7:75812358 T/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.48 -7.2 -0.37 3.96e-12 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9875589 0.509 rs6783645 chr3:14024542 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 7.01 0.36 1.32e-11 Ovarian reserve; LUSC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg01475377 chr6:109611718 NA -0.37 -6.55 -0.34 2.18e-10 Reticulocyte fraction of red cells; LUSC cis rs2777491 0.872 rs61037359 chr15:41585926 T/C cg18705301 chr15:41695430 NDUFAF1 -0.74 -14.48 -0.62 3.28e-37 Ulcerative colitis; LUSC cis rs1215050 0.740 rs783945 chr4:99014394 G/A cg05340658 chr4:99064831 C4orf37 -0.44 -7.0 -0.36 1.39e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg17279839 chr7:150038598 RARRES2 0.55 8.11 0.41 9.5e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs2688608 0.869 rs2250140 chr10:75612881 T/C cg23231163 chr10:75533350 FUT11 -0.39 -6.26 -0.32 1.21e-9 Inflammatory bowel disease; LUSC cis rs2932538 0.922 rs12048528 chr1:113210534 A/C cg22162597 chr1:113214053 CAPZA1 -0.68 -9.72 -0.47 8.05e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs7188861 0.681 rs1345880 chr16:11404857 G/T cg00044050 chr16:11439710 C16orf75 0.57 5.79 0.3 1.66e-8 HDL cholesterol; LUSC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg04352962 chr1:209979756 IRF6 0.5 6.74 0.35 7.02e-11 Cleft lip with or without cleft palate; LUSC trans rs11098499 0.780 rs10013652 chr4:120292256 A/G cg25214090 chr10:38739885 LOC399744 0.49 7.45 0.38 8e-13 Corneal astigmatism; LUSC cis rs951366 0.705 rs6673687 chr1:205670369 A/T cg17178900 chr1:205818956 PM20D1 -0.4 -5.68 -0.3 2.88e-8 Menarche (age at onset); LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg11645453 chr3:52864694 ITIH4 0.34 7.91 0.4 3.72e-14 Bipolar disorder; LUSC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg01420254 chr6:26195488 NA 0.72 7.5 0.38 5.65e-13 Gout;Renal underexcretion gout; LUSC trans rs9329221 0.527 rs34259385 chr8:10325456 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.4 -0.33 5.19e-10 Neuroticism; LUSC trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg23505145 chr19:12996616 KLF1 0.64 10.97 0.51 4.2e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs34779708 0.931 rs2490663 chr10:35329735 A/G cg03585969 chr10:35415529 CREM -0.6 -8.88 -0.44 4.16e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 13.63 0.6 5.91e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6598955 0.543 rs6699798 chr1:26556442 G/T cg12744634 chr1:26560303 CCDC21 0.38 5.66 0.3 3.33e-8 Obesity-related traits; LUSC cis rs12519773 0.501 rs10428523 chr5:92536365 G/A cg18783429 chr5:92414398 NA 0.34 7.15 0.36 5.41e-12 Migraine; LUSC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.64 6.16 0.32 2.07e-9 Cerebrospinal P-tau181p levels; LUSC cis rs9815354 0.812 rs73073361 chr3:41842926 C/G cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs9944715 0.911 rs8090542 chr18:43771364 G/A cg01718231 chr17:29326311 RNF135 -0.52 -7.44 -0.38 8.4e-13 Red cell distribution width;Mean corpuscular volume; LUSC trans rs931812 0.825 rs55818461 chr8:101899229 T/C cg20993868 chr7:22813445 NA 0.62 11.08 0.52 1.63e-24 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs748404 0.578 rs2278856 chr15:43631356 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.55 8.36 0.42 1.7e-15 Lung cancer; LUSC cis rs7707921 1.000 rs6888977 chr5:81533735 C/T cg15871215 chr5:81402204 ATG10 0.45 6.88 0.35 2.99e-11 Breast cancer; LUSC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.16 16.28 0.67 2.76e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9296092 0.538 rs62407565 chr6:33535739 A/G cg13560919 chr6:33536144 NA -0.86 -16.9 -0.68 1.02e-46 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9658691 0.607 rs34891735 chr10:90779212 A/T cg03111039 chr10:90751583 FAS;ACTA2 -0.6 -6.15 -0.32 2.25e-9 Mosquito bite size; LUSC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg03517284 chr6:25882590 NA 0.65 11.4 0.53 1.23e-25 Blood metabolite levels; LUSC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.47 -0.8 1.82e-76 Height; LUSC trans rs370763 0.547 rs6872582 chr5:64400653 A/G cg23238483 chr3:3886090 LRRN1 -0.38 -6.03 -0.31 4.39e-9 Inguinal hernia; LUSC cis rs9929218 0.551 rs7201437 chr16:68727130 A/C cg01251360 chr16:68772225 CDH1 -0.25 -5.81 -0.3 1.47e-8 Colorectal cancer; LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg08888203 chr3:10149979 C3orf24 0.65 8.99 0.44 1.81e-17 Alzheimer's disease; LUSC cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.66 -0.3 3.26e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs2439831 1.000 rs2467740 chr15:43746792 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.43 0.53 9.55e-26 Lung cancer in ever smokers; LUSC trans rs1325195 0.920 rs2816186 chr1:179122779 T/C cg11624085 chr17:8464688 MYH10 0.42 6.85 0.35 3.64e-11 IgE grass sensitization; LUSC cis rs11122272 0.735 rs2790890 chr1:231514567 C/T cg06096015 chr1:231504339 EGLN1 0.56 9.88 0.48 2.27e-20 Hemoglobin concentration; LUSC cis rs11955175 1.000 rs11953977 chr5:40674690 G/C cg05478818 chr5:40835740 RPL37 0.7 5.77 0.3 1.81e-8 Bipolar disorder and schizophrenia; LUSC trans rs2665103 0.687 rs11633000 chr15:82561661 C/G cg18393722 chr15:85113863 UBE2QP1 -0.44 -6.83 -0.35 3.96e-11 Intelligence (multi-trait analysis); LUSC cis rs61897795 0.628 rs174579 chr11:61605613 C/T cg06781209 chr11:61594997 FADS2 -0.43 -6.52 -0.34 2.53e-10 Neutrophil count;Sum basophil neutrophil counts; LUSC trans rs2243480 1.000 rs35391607 chr7:65360829 G/A cg10756647 chr7:56101905 PSPH 0.87 8.39 0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg22963979 chr7:1858916 MAD1L1 -0.51 -7.65 -0.39 2.14e-13 Bipolar disorder and schizophrenia; LUSC cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs983392 0.559 rs1426249 chr11:60002261 C/A cg24026212 chr11:59952134 MS4A6A -0.35 -5.92 -0.31 8.06e-9 Alzheimer's disease (late onset); LUSC cis rs2742234 0.590 rs2503864 chr10:43666767 G/T cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg05313129 chr8:58192883 C8orf71 -0.59 -6.35 -0.33 6.85e-10 Developmental language disorder (linguistic errors); LUSC cis rs3820928 0.935 rs12151597 chr2:227859224 A/G cg11843606 chr2:227700838 RHBDD1 -0.51 -7.31 -0.37 1.99e-12 Pulmonary function; LUSC cis rs9905704 0.647 rs11079367 chr17:57009024 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.35 -0.37 1.51e-12 Testicular germ cell tumor; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg09703963 chr11:616879 IRF7;MUPCDH -0.4 -6.41 -0.33 4.92e-10 Systemic lupus erythematosus; LUSC cis rs12891047 0.866 rs181564 chr14:68279356 A/G cg20999565 chr14:68265668 ZFYVE26 -0.37 -5.68 -0.3 2.95e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs400736 0.671 rs2472862 chr1:7991203 G/A cg25007680 chr1:8021821 PARK7 -0.47 -6.88 -0.35 2.89e-11 Response to antidepressants and depression; LUSC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9341808 0.600 rs668329 chr6:80968578 G/A cg08355045 chr6:80787529 NA -0.41 -6.9 -0.35 2.65e-11 Sitting height ratio; LUSC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg08027265 chr7:2291960 NA -0.36 -5.79 -0.3 1.58e-8 Bipolar disorder and schizophrenia; LUSC cis rs79911532 0.515 rs78827697 chr7:75687725 C/G cg03592824 chr7:75666768 STYXL1 0.69 6.81 0.35 4.46e-11 Mononucleosis; LUSC cis rs10162002 1.000 rs73449251 chr13:24042272 C/T cg00158254 chr13:24040743 NA 0.54 6.01 0.31 4.73e-9 Hypothyroidism; LUSC cis rs62244186 0.659 rs12108134 chr3:44543030 A/G cg02073558 chr3:44770973 ZNF501 -0.44 -6.93 -0.35 2.17e-11 Depressive symptoms; LUSC cis rs4969178 0.965 rs8075131 chr17:76394595 T/G cg05887092 chr17:76393375 PGS1 0.52 9.5 0.46 4.27e-19 HDL cholesterol levels; LUSC cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg06064525 chr11:970664 AP2A2 -0.49 -10.53 -0.5 1.39e-22 Alzheimer's disease (late onset); LUSC cis rs7100689 0.646 rs10736346 chr10:82134281 A/C cg01528321 chr10:82214614 TSPAN14 0.87 13.27 0.59 1.39e-32 Post bronchodilator FEV1; LUSC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg04455712 chr21:45112962 RRP1B 0.48 9.0 0.44 1.76e-17 Mean corpuscular volume; LUSC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.09 0.4 1.14e-14 Prudent dietary pattern; LUSC cis rs7100689 0.646 rs2050824 chr10:82123563 G/A cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs7572733 0.515 rs12619300 chr2:198786490 A/C cg00792783 chr2:198669748 PLCL1 -0.44 -5.96 -0.31 6.57e-9 Dermatomyositis; LUSC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.35 -0.37 1.57e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg22535103 chr8:58192502 C8orf71 -0.76 -6.44 -0.33 4.28e-10 Developmental language disorder (linguistic errors); LUSC cis rs1003719 0.713 rs7277150 chr21:38490006 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.24 0.52 4.29e-25 Eye color traits; LUSC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg09436375 chr6:42928200 GNMT 0.24 5.65 0.3 3.36e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg22166914 chr1:53195759 ZYG11B 0.5 7.97 0.4 2.55e-14 Monocyte count; LUSC cis rs9815354 0.812 rs73073230 chr3:42008263 G/A cg03022575 chr3:42003672 ULK4 0.82 8.57 0.42 3.93e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg18876405 chr7:65276391 NA -0.7 -12.66 -0.57 2.88e-30 Aortic root size; LUSC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg18230493 chr5:56204884 C5orf35 -0.61 -8.82 -0.43 6.24e-17 Type 2 diabetes; LUSC cis rs2235649 0.843 rs9932890 chr16:1847868 G/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 0.43 5.97 0.31 6.08e-9 Blood metabolite levels; LUSC cis rs1448094 0.717 rs7305873 chr12:86290831 G/C cg25456477 chr12:86230367 RASSF9 0.39 6.84 0.35 3.72e-11 Major depressive disorder; LUSC trans rs8072100 1.000 rs8065669 chr17:45724996 G/A cg03886242 chr7:26192032 NFE2L3 -0.37 -6.07 -0.32 3.55e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7615316 0.751 rs9847364 chr3:142155763 A/G cg16271453 chr3:142027066 XRN1 -0.42 -7.33 -0.37 1.77e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9303401 0.592 rs66583824 chr17:56639853 C/T cg25039879 chr17:56429692 SUPT4H1 0.66 8.88 0.44 4.12e-17 Cognitive test performance; LUSC cis rs12200560 0.505 rs172425 chr6:97075299 A/T cg06623918 chr6:96969491 KIAA0776 0.5 7.2 0.37 3.9e-12 Coronary heart disease; LUSC cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.08 0.44 9.59e-18 Motion sickness; LUSC cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.98 -0.44 1.98e-17 Monocyte percentage of white cells; LUSC cis rs1215050 0.669 rs783962 chr4:98884473 G/A cg05340658 chr4:99064831 C4orf37 -0.39 -6.02 -0.31 4.58e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg23985595 chr17:80112537 CCDC57 -0.33 -6.39 -0.33 5.61e-10 Life satisfaction; LUSC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg12463550 chr7:65579703 CRCP -0.51 -7.47 -0.38 7.17e-13 Aortic root size; LUSC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs7584330 0.737 rs6431539 chr2:238360708 G/T cg16989719 chr2:238392110 NA -0.37 -6.36 -0.33 6.66e-10 Prostate cancer; LUSC cis rs931127 0.836 rs523029 chr11:65476487 T/G cg05805236 chr11:65401703 PCNXL3 -0.41 -6.79 -0.35 5.3e-11 Systemic lupus erythematosus; LUSC cis rs12908161 0.959 rs3748376 chr15:85328352 C/T cg12863693 chr15:85201151 NMB 0.39 7.83 0.39 6.58e-14 Schizophrenia; LUSC cis rs9925964 0.933 rs4889530 chr16:31065918 T/A cg02466173 chr16:30829666 NA 0.35 6.33 0.33 7.84e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7267979 1.000 rs2297496 chr20:25295787 T/C cg08601574 chr20:25228251 PYGB -0.43 -6.59 -0.34 1.69e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10493773 0.609 rs12097932 chr1:86182216 A/G cg17807903 chr1:86174739 ZNHIT6 -0.54 -14.85 -0.63 1.21e-38 Urate levels in overweight individuals; LUSC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg06505273 chr16:24850292 NA 0.41 5.7 0.3 2.58e-8 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg07936489 chr17:37558343 FBXL20 0.71 9.63 0.47 1.55e-19 Glomerular filtration rate (creatinine); LUSC cis rs6951245 0.744 rs10275401 chr7:1213943 A/C cg03188948 chr7:1209495 NA 0.68 7.83 0.39 6.68e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs240764 0.853 rs10457809 chr6:100984400 C/T cg09795085 chr6:101329169 ASCC3 -0.41 -5.89 -0.31 9.28e-9 Neuroticism; LUSC cis rs8060686 0.516 rs73612297 chr16:68284754 T/G cg05110241 chr16:68378359 PRMT7 -0.53 -6.55 -0.34 2.14e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs7586879 0.964 rs4077679 chr2:25122852 T/C cg04586622 chr2:25135609 ADCY3 0.32 6.22 0.32 1.51e-9 Body mass index; LUSC cis rs2486288 0.656 rs6493145 chr15:45573862 G/T cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.69 -0.39 1.62e-13 Glomerular filtration rate; LUSC cis rs9467773 0.526 rs9688946 chr6:26367445 C/A cg09904177 chr6:26538194 HMGN4 -0.48 -7.56 -0.38 3.93e-13 Intelligence (multi-trait analysis); LUSC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18404041 chr3:52824283 ITIH1 -0.45 -8.77 -0.43 9.38e-17 Bipolar disorder; LUSC cis rs6701037 1.000 rs11585617 chr1:175123186 C/G cg17845761 chr1:175162550 KIAA0040 -0.32 -6.16 -0.32 2.06e-9 Alcohol dependence; LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg19717773 chr7:2847554 GNA12 -0.35 -5.67 -0.3 3.17e-8 Height; LUSC cis rs4363385 0.667 rs454186 chr1:153049149 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.65 -0.3 3.48e-8 Inflammatory skin disease; LUSC cis rs9788682 0.895 rs3813570 chr15:78832832 T/C cg18825076 chr15:78729989 IREB2 0.46 6.14 0.32 2.35e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1018697 1.000 rs7073114 chr10:104555651 C/T cg04362960 chr10:104952993 NT5C2 0.46 6.41 0.33 5.1e-10 Colorectal adenoma (advanced); LUSC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg20283391 chr11:68216788 NA -0.52 -7.67 -0.39 1.9e-13 Total body bone mineral density; LUSC cis rs2580764 0.598 rs6755468 chr2:55240026 A/C cg09592903 chr2:55203963 RTN4 -0.49 -10.14 -0.49 2.97e-21 Mean platelet volume; LUSC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.12 0.52 1.18e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg21433313 chr16:3507492 NAT15 -0.81 -8.92 -0.44 3.07e-17 Tuberculosis; LUSC trans rs867371 0.502 rs28610286 chr15:82525655 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.38 -0.33 5.88e-10 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs10489525 0.599 rs7526323 chr1:115604241 G/A cg01522456 chr1:115632236 TSPAN2 0.51 7.6 0.38 3.08e-13 Autism; LUSC cis rs4629180 1.000 rs908133 chr2:102092374 A/C cg04415270 chr2:102091202 RFX8 -0.55 -8.88 -0.44 4.14e-17 Chronic rhinosinusitis with nasal polyps; LUSC cis rs1113500 0.933 rs12035689 chr1:108636756 T/C cg11967332 chr1:108735228 SLC25A24 0.39 5.97 0.31 6.23e-9 Growth-regulated protein alpha levels; LUSC cis rs35883536 0.545 rs115017855 chr1:101101830 T/A cg06223162 chr1:101003688 GPR88 0.36 6.32 0.33 8.21e-10 Monocyte count; LUSC cis rs9420 0.961 rs10896647 chr11:57571883 C/T cg02958346 chr11:57425731 CLP1 -0.44 -6.4 -0.33 5.12e-10 Schizophrenia; LUSC trans rs1922233 0.943 rs1922229 chr4:92375659 T/C cg24250684 chr1:219729030 NA -0.36 -6.48 -0.33 3.29e-10 Gut microbiome composition (summer and winter); LUSC cis rs4474465 0.688 rs7108439 chr11:78277708 A/T cg27205649 chr11:78285834 NARS2 0.56 6.87 0.35 3.23e-11 Alzheimer's disease (survival time); LUSC cis rs7647973 0.731 rs7617480 chr3:49210732 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.42 -6.29 -0.33 1.01e-9 Menarche (age at onset); LUSC cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg00321850 chr1:175162397 KIAA0040 0.46 7.87 0.4 4.94e-14 Alcohol dependence; LUSC cis rs9814567 1.000 rs1534025 chr3:134313304 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.85 14.02 0.61 1.89e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -6.73 -0.35 7.51e-11 Major depressive disorder; LUSC trans rs7824557 0.564 rs34389419 chr8:11229319 C/G cg08975724 chr8:8085496 FLJ10661 -0.48 -6.99 -0.36 1.49e-11 Retinal vascular caliber; LUSC cis rs8060686 0.516 rs7194894 chr16:68145062 C/T cg27539214 chr16:67997921 SLC12A4 -0.55 -7.56 -0.38 3.86e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9309473 0.583 rs6546822 chr2:73575098 G/A cg20560298 chr2:73613845 ALMS1 -0.51 -7.38 -0.37 1.27e-12 Metabolite levels; LUSC cis rs9329221 0.537 rs13254175 chr8:9978772 C/T cg27411982 chr8:10470053 RP1L1 0.37 5.76 0.3 1.88e-8 Neuroticism; LUSC cis rs7824557 0.564 rs2572399 chr8:11234520 A/G cg21775007 chr8:11205619 TDH -0.67 -10.67 -0.5 4.64e-23 Retinal vascular caliber; LUSC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg06808227 chr14:105710500 BRF1 -0.71 -11.54 -0.53 3.73e-26 Mean platelet volume;Platelet distribution width; LUSC cis rs7267979 0.933 rs11699203 chr20:25435169 G/C cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 0.39 6.67 0.34 1.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg06212747 chr3:49208901 KLHDC8B 0.43 5.81 0.3 1.43e-8 Parkinson's disease; LUSC cis rs7824557 0.872 rs1347410 chr8:11111242 G/A cg21775007 chr8:11205619 TDH -0.57 -8.74 -0.43 1.19e-16 Retinal vascular caliber; LUSC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.42 -0.38 9.84e-13 Aortic root size; LUSC trans rs2197308 0.655 rs1971964 chr12:37870474 C/T cg06521331 chr12:34319734 NA -0.4 -6.03 -0.31 4.31e-9 Morning vs. evening chronotype; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg16145915 chr7:1198662 ZFAND2A -0.69 -13.36 -0.59 6.41e-33 Longevity;Endometriosis; LUSC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg21171335 chr12:122356390 WDR66 0.63 9.47 0.46 5.14e-19 Mean corpuscular volume; LUSC trans rs34421088 0.576 rs2736369 chr8:11101398 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -6.99 -0.36 1.53e-11 Neuroticism; LUSC cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg26384229 chr12:38710491 ALG10B 0.91 15.28 0.64 2.36e-40 Bladder cancer; LUSC cis rs4845570 1.000 rs6673002 chr1:151743275 G/T cg07092448 chr1:151763213 TDRKH 1.26 14.48 0.62 3.09e-37 Coronary artery disease; LUSC cis rs16958440 0.708 rs62096462 chr18:44625179 C/G cg17192377 chr18:44677553 HDHD2 0.43 5.67 0.3 3.06e-8 Sitting height ratio; LUSC cis rs1358748 0.555 rs7528804 chr1:67593819 C/T cg02640540 chr1:67518911 SLC35D1 0.69 6.63 0.34 1.38e-10 Tuberculosis; LUSC cis rs4253772 0.515 rs7287164 chr22:46781008 T/C cg24881330 chr22:46731750 TRMU 0.81 6.23 0.32 1.39e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs12931792 0.712 rs4787495 chr16:30165725 C/T cg17640201 chr16:30407289 ZNF48 -0.55 -8.64 -0.43 2.38e-16 Tonsillectomy; LUSC cis rs1044826 0.957 rs4544576 chr3:139143196 G/T cg00490450 chr3:139108681 COPB2 0.55 7.36 0.37 1.44e-12 Obesity-related traits; LUSC cis rs754466 0.580 rs11002289 chr10:79532580 G/A cg17075019 chr10:79541650 NA -0.77 -12.27 -0.56 8.08e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.865 rs11098513 chr4:120316075 A/G cg24375607 chr4:120327624 NA 0.75 10.65 0.5 5.47e-23 Corneal astigmatism; LUSC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg11062466 chr8:58055876 NA 0.75 9.12 0.45 7.24e-18 Developmental language disorder (linguistic errors); LUSC cis rs2637266 1.000 rs12258924 chr10:78364758 G/A cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs75920871 0.528 rs11216241 chr11:116899249 A/C cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.42 -0.33 4.68e-10 Subjective well-being; LUSC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg05025164 chr4:1340916 KIAA1530 0.62 10.07 0.48 5.32e-21 Longevity; LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg01879757 chr17:41196368 BRCA1 -0.4 -6.12 -0.32 2.62e-9 Menopause (age at onset); LUSC cis rs240764 0.817 rs240146 chr6:101078718 G/A cg09795085 chr6:101329169 ASCC3 0.42 6.04 0.31 4.03e-9 Neuroticism; LUSC cis rs2840044 1.000 rs2840044 chr17:33892068 A/G cg05299278 chr17:33885742 SLFN14 -0.3 -6.36 -0.33 6.82e-10 Response to radiotherapy in cancer (late toxicity); LUSC cis rs3096299 0.967 rs2965830 chr16:89460290 T/C cg02187348 chr16:89574699 SPG7 0.48 7.54 0.38 4.47e-13 Multiple myeloma (IgH translocation); LUSC cis rs7589342 0.598 rs7602442 chr2:106402795 C/T cg14210321 chr2:106509881 NCK2 0.41 5.86 0.31 1.13e-8 Addiction; LUSC cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 11.93 0.55 1.41e-27 Colorectal cancer; LUSC cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.05e-43 Bladder cancer; LUSC cis rs7582180 0.585 rs6736311 chr2:100950599 C/G cg12002119 chr2:101014098 CHST10 0.36 5.99 0.31 5.44e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg08219700 chr8:58056026 NA 0.47 5.86 0.31 1.1e-8 Developmental language disorder (linguistic errors); LUSC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg18225595 chr11:63971243 STIP1 0.49 6.1 0.32 2.88e-9 Mean platelet volume; LUSC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs72781680 0.716 rs2551343 chr2:24027002 C/G cg08917208 chr2:24149416 ATAD2B 0.63 7.2 0.37 4.03e-12 Lymphocyte counts; LUSC trans rs9944715 0.906 rs7241527 chr18:43736932 G/A cg01718231 chr17:29326311 RNF135 0.45 6.15 0.32 2.24e-9 Red cell distribution width;Mean corpuscular volume; LUSC cis rs6582630 0.576 rs11504369 chr12:38274566 C/T cg26384229 chr12:38710491 ALG10B -0.58 -8.74 -0.43 1.19e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs6906287 0.647 rs12214483 chr6:118780146 G/C cg21191810 chr6:118973309 C6orf204 0.33 6.0 0.31 5.17e-9 Electrocardiographic conduction measures; LUSC cis rs1957429 0.614 rs61012404 chr14:65347649 C/T cg23373153 chr14:65346875 NA -1.03 -9.4 -0.46 8.72e-19 Pediatric areal bone mineral density (radius); LUSC cis rs7113850 0.541 rs4360696 chr11:24217119 C/G ch.11.24196551F chr11:24239977 NA 0.96 8.77 0.43 9.54e-17 Bone fracture in osteoporosis; LUSC cis rs11711311 1.000 rs13070720 chr3:113473754 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.92 0.35 2.38e-11 IgG glycosylation; LUSC cis rs1113500 0.932 rs1343205 chr1:108597873 C/G cg06207961 chr1:108661230 NA 0.4 7.45 0.38 8.24e-13 Growth-regulated protein alpha levels; LUSC cis rs11122272 0.735 rs1416916 chr1:231533027 A/G cg06096015 chr1:231504339 EGLN1 0.58 10.37 0.49 5e-22 Hemoglobin concentration; LUSC cis rs6691722 0.506 rs11587667 chr1:24715435 C/G cg02336364 chr1:24764700 NIPAL3 0.35 6.2 0.32 1.66e-9 Response to interferon beta in multiple sclerosis; LUSC trans rs11611246 0.882 rs2286028 chr12:1015469 C/G cg27417659 chr7:98567827 TRRAP -0.46 -6.15 -0.32 2.16e-9 Body mass index; LUSC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.59 -0.54 2.5e-26 Schizophrenia; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg07212969 chr2:241506132 NA -0.49 -6.54 -0.34 2.32e-10 Hepatitis; LUSC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.31 0.53 2.45e-25 Menopause (age at onset); LUSC cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg08085267 chr17:45401833 C17orf57 -0.46 -6.83 -0.35 4.13e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7833986 1.000 rs66553445 chr8:57096781 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.63 9.35 0.46 1.28e-18 Height; LUSC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg16386425 chr10:429943 DIP2C -0.38 -6.03 -0.31 4.43e-9 Psychosis in Alzheimer's disease; LUSC cis rs1865760 0.827 rs9461227 chr6:25960815 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 6.88 0.35 2.99e-11 Height; LUSC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg03433033 chr1:76189801 ACADM 0.8 12.36 0.56 3.63e-29 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05756109 chr10:103347662 POLL;RP11-529I10.4 0.4 6.19 0.32 1.78e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7618501 0.602 rs2071207 chr3:50159844 T/C cg21659725 chr3:3221576 CRBN -0.61 -10.09 -0.48 4.34e-21 Intelligence (multi-trait analysis); LUSC cis rs7799006 0.929 rs6951493 chr7:2257612 G/A cg12823233 chr7:2316876 SNX8 -0.35 -5.85 -0.3 1.18e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4595586 0.525 rs1400279 chr12:39343825 T/A cg26384229 chr12:38710491 ALG10B 0.55 7.79 0.39 8.68e-14 Morning vs. evening chronotype; LUSC cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg07424592 chr7:64974309 NA 0.67 5.98 0.31 5.72e-9 Diabetic kidney disease; LUSC cis rs34734847 1.000 rs10431385 chr12:121128882 T/C cg27246729 chr12:121163418 ACADS 0.46 7.38 0.37 1.3e-12 Mean corpuscular volume; LUSC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg26850624 chr5:429559 AHRR -0.37 -6.86 -0.35 3.34e-11 Cystic fibrosis severity; LUSC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg16606324 chr3:10149918 C3orf24 0.44 6.83 0.35 4.05e-11 Alzheimer's disease; LUSC cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 7.23 0.37 3.38e-12 Rheumatoid arthritis; LUSC cis rs2224391 0.628 rs1609808 chr6:5246333 C/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.49 -6.61 -0.34 1.5e-10 Height; LUSC cis rs7119 0.717 rs62007348 chr15:77804501 C/T cg27398640 chr15:77910606 LINGO1 -0.29 -6.08 -0.32 3.2e-9 Type 2 diabetes; LUSC cis rs28374715 0.578 rs7169543 chr15:41620405 T/C cg18705301 chr15:41695430 NDUFAF1 -1.07 -22.54 -0.78 4.9e-69 Ulcerative colitis; LUSC trans rs35110281 0.633 rs762400 chr21:45113629 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.65 -11.41 -0.53 1.07e-25 Mean corpuscular volume; LUSC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg15664640 chr17:80829946 TBCD -0.73 -12.72 -0.57 1.69e-30 Breast cancer; LUSC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg04450456 chr4:17643702 FAM184B 0.4 6.86 0.35 3.27e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2282300 0.739 rs10835648 chr11:30320506 A/G cg25418670 chr11:30344373 C11orf46 0.61 8.73 0.43 1.26e-16 Morning vs. evening chronotype; LUSC cis rs7712401 0.623 rs30044 chr5:122272080 T/C cg19077854 chr5:122220652 SNX24 0.41 9.01 0.44 1.58e-17 Mean platelet volume; LUSC trans rs3889199 0.859 rs6587848 chr1:59657488 A/C cg24327262 chr19:46929907 NA -0.38 -6.12 -0.32 2.69e-9 Pulse pressure; LUSC cis rs7923609 0.967 rs7085018 chr10:65286667 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.46 -0.33 3.74e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs2950393 0.804 rs898611 chr12:57163316 A/G cg14367344 chr1:146644336 PRKAB2 0.43 6.11 0.32 2.8e-9 Platelet distribution width; LUSC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC trans rs7819412 0.521 rs10110684 chr8:11039159 G/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.05 -0.31 3.9e-9 Triglycerides; LUSC cis rs7520050 0.778 rs2088102 chr1:46032974 T/C cg24296786 chr1:45957014 TESK2 0.46 6.52 0.34 2.65e-10 Red blood cell count;Reticulocyte count; LUSC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg07362569 chr17:61921086 SMARCD2 -0.32 -6.6 -0.34 1.66e-10 Prudent dietary pattern; LUSC cis rs765787 0.530 rs12903149 chr15:45539076 G/A cg25801113 chr15:45476975 SHF -0.35 -6.82 -0.35 4.34e-11 Uric acid levels; LUSC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg06618935 chr21:46677482 NA -0.39 -7.81 -0.39 7.65e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg11871910 chr12:69753446 YEATS4 0.65 9.94 0.48 1.49e-20 Blood protein levels; LUSC cis rs12421382 0.570 rs10789736 chr11:109478039 G/C cg27471124 chr11:109292789 C11orf87 0.38 6.53 0.34 2.4e-10 Schizophrenia; LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg05896524 chr21:47604654 C21orf56 0.52 8.05 0.4 1.51e-14 Testicular germ cell tumor; LUSC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs11971779 0.680 rs111461944 chr7:139077903 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs887829 0.570 rs13002774 chr2:234593706 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.21 -0.32 1.58e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs62400317 0.859 rs62400313 chr6:45256366 A/T cg18551225 chr6:44695536 NA -0.42 -6.99 -0.36 1.52e-11 Total body bone mineral density; LUSC cis rs3845702 0.935 rs6433822 chr2:180840422 G/C cg01881094 chr2:180872142 CWC22 -0.82 -10.71 -0.51 3.19e-23 Schizophrenia; LUSC cis rs6665290 0.904 rs2297418 chr1:227192579 A/C cg10327440 chr1:227177885 CDC42BPA -1.22 -40.05 -0.91 1.39e-129 Myeloid white cell count; LUSC cis rs6815814 0.898 rs5743562 chr4:38806096 T/C cg02016764 chr4:38805732 TLR1 -0.53 -5.74 -0.3 2.16e-8 Breast cancer; LUSC cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg23711669 chr6:146136114 FBXO30 -0.83 -15.09 -0.64 1.3e-39 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg18876405 chr7:65276391 NA -0.57 -9.3 -0.45 1.95e-18 Aortic root size; LUSC cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg03146154 chr1:46216737 IPP -0.5 -7.23 -0.37 3.29e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs12579753 0.917 rs6539580 chr12:82184765 T/C cg07923666 chr12:49932857 KCNH3 -0.49 -6.1 -0.32 3e-9 Resting heart rate; LUSC cis rs12310956 0.510 rs7301767 chr12:33886529 A/T cg06521331 chr12:34319734 NA -0.37 -6.09 -0.32 3.09e-9 Morning vs. evening chronotype; LUSC cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg07148914 chr20:33460835 GGT7 0.54 8.4 0.42 1.33e-15 Height; LUSC cis rs4363385 0.510 rs7541328 chr1:152894142 C/G cg25856811 chr1:152973957 SPRR3 -0.38 -6.21 -0.32 1.62e-9 Inflammatory skin disease; LUSC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg07701084 chr6:150067640 NUP43 0.57 8.74 0.43 1.16e-16 Lung cancer; LUSC trans rs1325195 0.803 rs10913696 chr1:179088721 A/T cg11624085 chr17:8464688 MYH10 -0.44 -7.38 -0.37 1.25e-12 IgE grass sensitization; LUSC cis rs1997103 0.871 rs9649855 chr7:55410222 T/C cg17469321 chr7:55412551 NA 0.64 10.38 0.49 4.6e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs17490626 0.568 rs12416520 chr10:71211945 A/G cg14388049 chr10:71211838 TSPAN15 -0.32 -5.81 -0.3 1.47e-8 Thrombosis; LUSC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg03676636 chr4:99064102 C4orf37 0.33 7.19 0.37 4.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg10130564 chr11:117069849 TAGLN 0.38 6.65 0.34 1.17e-10 Blood protein levels; LUSC cis rs7954584 0.567 rs11043233 chr12:122330733 C/T cg10207240 chr12:122356781 WDR66 0.47 6.77 0.35 5.69e-11 Mean corpuscular volume; LUSC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg04998671 chr14:104000505 TRMT61A -0.42 -5.94 -0.31 6.99e-9 Reticulocyte count; LUSC cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg04727924 chr7:799746 HEATR2 -0.55 -6.71 -0.34 8.16e-11 Cerebrospinal P-tau181p levels; LUSC cis rs2797160 1.000 rs1739378 chr6:126012262 C/A cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.98e-16 Endometrial cancer; LUSC cis rs1549118 0.669 rs11625414 chr14:78375344 A/G cg02301378 chr14:78227641 SNW1;C14orf178 -0.42 -5.77 -0.3 1.82e-8 Resting heart rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02850933 chr1:249167489 NA -0.42 -6.3 -0.33 9.37e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.55 -8.47 -0.42 7.87e-16 Personality dimensions; LUSC trans rs8073060 0.586 rs226087 chr17:34017652 T/C cg19694781 chr19:47549865 TMEM160 -1.13 -17.99 -0.7 4.71e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC trans rs62238980 0.614 rs75074953 chr22:32374314 C/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs72781680 0.898 rs72782117 chr2:24026921 G/A cg20701182 chr2:24300061 SF3B14 0.73 7.39 0.37 1.2e-12 Lymphocyte counts; LUSC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg03709012 chr19:19516395 GATAD2A 0.87 14.7 0.63 4.34e-38 Tonsillectomy; LUSC cis rs2012796 0.743 rs8020575 chr14:81859521 G/A cg02996355 chr14:81879375 NA 0.52 7.61 0.38 2.85e-13 Night sleep phenotypes; LUSC cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg13319975 chr6:146136371 FBXO30 0.49 7.43 0.38 9.4e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs826838 0.904 rs7973992 chr12:39168233 T/C cg26384229 chr12:38710491 ALG10B 0.9 17.13 0.68 1.15e-47 Heart rate; LUSC cis rs10876993 0.893 rs7979246 chr12:58092554 A/G cg18357645 chr12:58087776 OS9 0.6 9.07 0.44 1.01e-17 Celiac disease or Rheumatoid arthritis; LUSC cis rs56399783 0.901 rs73047393 chr7:2775879 C/T cg14895029 chr7:2775587 GNA12 0.53 5.82 0.3 1.41e-8 Childhood ear infection; LUSC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg02079420 chr8:82753780 SNX16 0.38 5.7 0.3 2.68e-8 Diastolic blood pressure; LUSC cis rs11758351 0.925 rs10452600 chr6:26192502 C/A cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC cis rs372883 0.869 rs2027605 chr21:30726773 A/G cg08807101 chr21:30365312 RNF160 0.41 6.14 0.32 2.29e-9 Pancreatic cancer; LUSC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg22800045 chr5:56110881 MAP3K1 0.79 10.07 0.48 5.15e-21 Initial pursuit acceleration; LUSC cis rs6546537 0.955 rs2312215 chr2:69839825 T/A cg10773587 chr2:69614142 GFPT1 -0.56 -8.41 -0.42 1.22e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs6964587 1.000 rs10488512 chr7:91753579 C/T cg01689657 chr7:91764605 CYP51A1 0.34 6.07 0.32 3.49e-9 Breast cancer; LUSC cis rs478304 0.593 rs2236682 chr11:65480090 G/T cg27068330 chr11:65405492 SIPA1 -0.75 -10.39 -0.49 4.12e-22 Acne (severe); LUSC cis rs10843647 1.000 rs4930900 chr12:30325008 T/C cg12718339 chr12:29936407 TMTC1 -0.36 -5.91 -0.31 8.65e-9 Glucose homeostasis traits; LUSC cis rs908922 0.676 rs10888491 chr1:152492622 A/G cg20991723 chr1:152506922 NA 0.54 10.32 0.49 7.39e-22 Hair morphology; LUSC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg15649852 chr7:65879115 NA 0.41 5.79 0.3 1.64e-8 Aortic root size; LUSC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.76 0.57 1.17e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7523050 0.643 rs35924015 chr1:109404626 T/C cg08274380 chr1:109419600 GPSM2 0.93 9.49 0.46 4.66e-19 Fat distribution (HIV); LUSC cis rs10193935 0.901 rs7605782 chr2:42502332 C/T cg27598129 chr2:42591480 NA -0.59 -7.88 -0.4 4.77e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs3820928 0.647 rs2115597 chr2:227791218 T/C cg11843606 chr2:227700838 RHBDD1 -0.66 -10.24 -0.49 1.43e-21 Pulmonary function; LUSC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg11764359 chr7:65958608 NA -0.71 -11.04 -0.52 2.31e-24 Aortic root size; LUSC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg00750074 chr16:89608354 SPG7 -0.57 -10.17 -0.49 2.36e-21 Multiple myeloma (IgH translocation); LUSC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg07636037 chr3:49044803 WDR6 0.44 6.35 0.33 7.23e-10 Resting heart rate; LUSC cis rs1113500 0.933 rs11185255 chr1:108633191 T/A cg06207961 chr1:108661230 NA 0.41 7.61 0.38 2.89e-13 Growth-regulated protein alpha levels; LUSC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11644478 chr21:40555479 PSMG1 -0.81 -14.32 -0.62 1.36e-36 Cognitive function; LUSC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg13319975 chr6:146136371 FBXO30 -0.67 -10.04 -0.48 6.92e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs977987 0.806 rs7185640 chr16:75394399 A/G cg03315344 chr16:75512273 CHST6 0.48 9.26 0.45 2.6e-18 Dupuytren's disease; LUSC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg18477163 chr1:228402036 OBSCN -0.54 -10.17 -0.49 2.33e-21 Diastolic blood pressure; LUSC trans rs13219787 0.915 rs13214703 chr6:27941387 A/G cg01426208 chr6:29720641 NA 0.77 6.01 0.31 4.83e-9 Mean corpuscular volume;Hemoglobin levels;Mean corpuscular hemoglobin; LUSC cis rs6714788 0.565 rs9308833 chr2:100662618 C/T cg07810366 chr2:100720526 AFF3 -0.4 -6.35 -0.33 6.95e-10 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs11098499 0.562 rs58583086 chr4:120556362 A/G cg25214090 chr10:38739885 LOC399744 -0.4 -6.38 -0.33 6.06e-10 Corneal astigmatism; LUSC cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.0 14.25 0.61 2.51e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs67460515 0.563 rs13085336 chr3:160880599 G/A cg03342759 chr3:160939853 NMD3 -0.48 -6.69 -0.34 9.56e-11 Parkinson's disease; LUSC cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg22875332 chr1:76189707 ACADM 0.57 8.24 0.41 4.01e-15 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg13047869 chr3:10149882 C3orf24 0.61 8.24 0.41 3.97e-15 Alzheimer's disease; LUSC trans rs62458065 0.568 rs62466415 chr7:32518254 C/T cg00845942 chr12:64062724 DPY19L2 -0.52 -6.12 -0.32 2.6e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs10197940 0.578 rs2444264 chr2:152310928 G/T cg19508488 chr2:152266495 RIF1 -0.39 -5.71 -0.3 2.47e-8 Lung cancer; LUSC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11122272 0.735 rs2572253 chr1:231512768 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs548181 0.736 rs540723 chr11:125489621 A/G cg03464685 chr11:125439445 EI24 1.17 14.17 0.61 4.96e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg19539972 chr4:7069911 GRPEL1 -0.6 -6.09 -0.32 3.14e-9 Monocyte percentage of white cells; LUSC cis rs8078723 0.933 rs4794822 chr17:38156712 C/T cg17467752 chr17:38218738 THRA 0.77 12.47 0.56 1.47e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9788682 0.747 rs2656069 chr15:78745707 C/T cg24631222 chr15:78858424 CHRNA5 -0.64 -8.55 -0.42 4.48e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs709400 0.663 rs17679475 chr14:103916958 A/G cg10523860 chr14:103875565 MARK3 -0.36 -5.69 -0.3 2.79e-8 Body mass index; LUSC cis rs7945705 0.875 rs4929914 chr11:8824388 C/T cg12365402 chr11:9010492 NRIP3 -0.39 -6.79 -0.35 5.19e-11 Hemoglobin concentration; LUSC cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.99 0.4 2.18e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg11057378 chr10:81107060 PPIF 0.34 6.05 0.31 3.96e-9 Height; LUSC cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg24642439 chr20:33292090 TP53INP2 0.48 7.33 0.37 1.8e-12 Glomerular filtration rate (creatinine); LUSC cis rs4740619 0.905 rs6474974 chr9:15794897 C/G cg14451791 chr9:16040625 NA 0.31 5.94 0.31 7.3e-9 Body mass index; LUSC cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg26384229 chr12:38710491 ALG10B 0.88 15.08 0.64 1.52e-39 Morning vs. evening chronotype; LUSC cis rs7568458 0.905 rs10187424 chr2:85794297 T/C cg02493740 chr2:85810744 VAMP5 -0.32 -5.67 -0.3 3.1e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11644478 chr21:40555479 PSMG1 0.95 18.98 0.72 5.3e-55 Cognitive function; LUSC cis rs55910451 0.779 rs72774075 chr10:5764998 G/A cg11519256 chr10:5708881 ASB13 -0.48 -5.85 -0.3 1.19e-8 Breast cancer; LUSC trans rs7939886 0.920 rs7950386 chr11:55931513 C/T cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC cis rs7523273 0.548 rs3109808 chr1:207948477 C/A cg22525895 chr1:207977042 MIR29B2 0.41 6.6 0.34 1.6e-10 Schizophrenia; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13012494 chr21:47604986 C21orf56 0.46 6.87 0.35 3.18e-11 Testicular germ cell tumor; LUSC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg26314531 chr2:26401878 FAM59B 0.69 9.49 0.46 4.66e-19 Gut microbiome composition (summer); LUSC cis rs71403859 0.570 rs78972826 chr16:71454264 A/G cg08717414 chr16:71523259 ZNF19 -0.62 -7.03 -0.36 1.14e-11 Post bronchodilator FEV1; LUSC cis rs7264396 0.887 rs4911502 chr20:34063034 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -5.83 -0.3 1.28e-8 Total cholesterol levels; LUSC trans rs11098499 0.909 rs1809406 chr4:120377122 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.44 0.33 4.04e-10 Corneal astigmatism; LUSC cis rs2404602 0.692 rs35498563 chr15:76958868 C/T cg26408565 chr15:76604113 ETFA -0.48 -7.63 -0.39 2.4e-13 Blood metabolite levels; LUSC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg05084668 chr3:125655381 ALG1L -0.52 -7.96 -0.4 2.63e-14 Blood pressure (smoking interaction); LUSC cis rs753274 0.562 rs888876 chr19:14416793 T/C cg19560656 chr19:14444267 NA -0.35 -6.33 -0.33 7.75e-10 Tumor necrosis factor beta levels; LUSC cis rs9987353 0.620 rs34455383 chr8:9066458 C/T cg15556689 chr8:8085844 FLJ10661 -0.43 -5.9 -0.31 8.79e-9 Recombination measurement; LUSC cis rs4474465 0.920 rs4945285 chr11:78221698 C/T cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.14 15.8 0.65 2.11e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg11663144 chr21:46675770 NA 0.41 7.15 0.36 5.37e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9296092 0.517 rs76361685 chr6:33536458 G/C cg13560919 chr6:33536144 NA -0.87 -16.89 -0.68 1.09e-46 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9522267 0.535 rs6492373 chr13:112238627 T/C cg10483660 chr13:112241077 NA 0.31 5.77 0.3 1.8e-8 Hepatitis; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.17 -0.37 4.82e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12410462 0.581 rs7547204 chr1:227560909 C/T cg23173402 chr1:227635558 NA 0.56 6.26 0.32 1.2e-9 Major depressive disorder; LUSC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.74 -0.35 6.88e-11 Lung cancer; LUSC cis rs7267979 0.873 rs6083853 chr20:25404541 T/C cg03522245 chr20:25566470 NINL -0.35 -5.77 -0.3 1.83e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9549367 0.713 rs1323315 chr13:113859658 T/C cg18105134 chr13:113819100 PROZ 0.65 9.75 0.47 6.22e-20 Platelet distribution width; LUSC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg10360139 chr7:1886902 MAD1L1 -0.39 -5.91 -0.31 8.48e-9 Bipolar disorder and schizophrenia; LUSC cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg24642439 chr20:33292090 TP53INP2 0.5 7.5 0.38 5.77e-13 Glomerular filtration rate (creatinine); LUSC cis rs1577917 1.000 rs12216328 chr6:86703418 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -8.68 -0.43 1.8e-16 Response to antipsychotic treatment; LUSC trans rs61931739 0.500 rs11836198 chr12:34552782 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.45 0.59 3.01e-33 Morning vs. evening chronotype; LUSC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg16145915 chr7:1198662 ZFAND2A -0.43 -6.29 -0.33 9.99e-10 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg05313129 chr8:58192883 C8orf71 0.51 5.97 0.31 6.22e-9 Developmental language disorder (linguistic errors); LUSC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 10.01 0.48 8.46e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.75 0.65 3.43e-42 Platelet count; LUSC cis rs7829975 0.846 rs11779061 chr8:8549432 G/A cg08975724 chr8:8085496 FLJ10661 -0.45 -6.47 -0.33 3.43e-10 Mood instability; LUSC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg18825119 chr6:163149453 PACRG;PARK2 -0.45 -6.93 -0.35 2.21e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg06784218 chr1:46089804 CCDC17 -0.56 -11.07 -0.52 1.85e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6722750 0.716 rs1973848 chr2:64418456 T/C cg22352474 chr2:64371530 PELI1 -0.53 -7.94 -0.4 3.04e-14 Neuroticism; LUSC cis rs7666738 0.606 rs10006414 chr4:99101401 T/C cg17366294 chr4:99064904 C4orf37 0.53 9.09 0.45 8.73e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15506890 chr2:3487001 NA -0.53 -8.88 -0.44 4.21e-17 Neurofibrillary tangles; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25953536 chr17:26684567 POLDIP2;TMEM199 0.67 5.94 0.31 7.02e-9 Cognitive performance; LUSC cis rs2004776 0.656 rs12042306 chr1:230866063 G/A cg07502417 chr1:230849801 AGT 0.25 5.8 0.3 1.51e-8 Diastolic blood pressure; LUSC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg27427491 chr17:78079615 GAA -0.44 -7.49 -0.38 6.08e-13 Yeast infection; LUSC cis rs859767 0.741 rs11682346 chr2:135388261 G/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.36 -0.33 6.66e-10 Neuroticism; LUSC cis rs36715 1.000 rs36697 chr5:127549613 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.53 6.93 0.35 2.18e-11 Breast cancer; LUSC cis rs11098499 0.644 rs10009566 chr4:120558608 A/G cg09307838 chr4:120376055 NA 0.64 9.71 0.47 8.2e-20 Corneal astigmatism; LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7230711 1.000 rs60651868 chr18:48781036 C/T cg07422195 chr1:23894874 NA -0.6 -5.95 -0.31 6.87e-9 Immune response to anthrax vaccine; LUSC cis rs5769765 0.908 rs7410318 chr22:50317049 T/C cg26441486 chr22:50317300 CRELD2 0.5 7.26 0.37 2.79e-12 Schizophrenia; LUSC trans rs9944715 1.000 rs9959813 chr18:43841082 C/T cg01718231 chr17:29326311 RNF135 0.54 7.43 0.38 9.28e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs11153306 0.818 rs7764009 chr6:111944596 G/T cg22127309 chr6:111907043 TRAF3IP2 0.33 6.3 0.33 9.58e-10 Tonsillectomy; LUSC trans rs2392780 0.896 rs13249993 chr8:128350515 G/A cg10897648 chr18:56338258 MALT1 -0.4 -5.97 -0.31 6.19e-9 Breast cancer (early onset); LUSC cis rs6547741 0.816 rs7560847 chr2:27882700 A/G cg27432699 chr2:27873401 GPN1 -0.89 -17.81 -0.7 2.35e-50 Oral cavity cancer; LUSC trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs9910055 0.762 rs227579 chr17:42223134 A/T cg16434002 chr17:42200994 HDAC5 0.45 6.3 0.33 9.28e-10 Total body bone mineral density; LUSC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg05973401 chr12:123451056 ABCB9 0.54 6.68 0.34 1.01e-10 Neutrophil percentage of white cells; LUSC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg25767906 chr1:53392781 SCP2 0.45 7.9 0.4 4.06e-14 Monocyte count; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg24846343 chr22:24311635 DDTL 0.78 17.87 0.7 1.41e-50 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs367943 0.712 rs9326888 chr5:112731133 A/C cg12552261 chr5:112820674 MCC 0.36 5.87 0.31 1.03e-8 Type 2 diabetes; LUSC cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg07157834 chr1:205819609 PM20D1 0.85 15.28 0.64 2.52e-40 Menarche (age at onset); LUSC cis rs6723226 0.765 rs12612824 chr2:32579759 C/T cg02381751 chr2:32503542 YIPF4 -0.62 -9.48 -0.46 4.88e-19 Intelligence (multi-trait analysis); LUSC cis rs929596 0.561 rs7564935 chr2:234645186 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.58 -9.69 -0.47 1.02e-19 Total bilirubin levels in HIV-1 infection; LUSC cis rs17030434 0.834 rs6535958 chr4:154760834 C/G cg14289246 chr4:154710475 SFRP2 0.42 5.73 0.3 2.26e-8 Electrocardiographic conduction measures; LUSC cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg17911788 chr17:44343683 NA -0.3 -5.72 -0.3 2.41e-8 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg06008330 chr7:65541103 ASL 0.4 6.2 0.32 1.64e-9 Aortic root size; LUSC cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg00071950 chr4:10020882 SLC2A9 -0.58 -9.78 -0.47 4.94e-20 Bone mineral density; LUSC cis rs11158026 0.757 rs56206440 chr14:55450886 T/C cg04306507 chr14:55594613 LGALS3 0.37 7.38 0.37 1.23e-12 Parkinson's disease; LUSC cis rs4820539 0.611 rs28451783 chr22:23488569 G/T cg21100191 chr22:23484243 RTDR1 0.7 10.23 0.49 1.46e-21 Bone mineral density; LUSC cis rs7927592 0.913 rs4988291 chr11:68381607 G/A cg20283391 chr11:68216788 NA -0.6 -8.37 -0.42 1.6e-15 Total body bone mineral density; LUSC trans rs7819412 0.521 rs10110684 chr8:11039159 G/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.19 -0.37 4.19e-12 Triglycerides; LUSC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Depression; LUSC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg01765077 chr12:122356316 WDR66 -0.53 -7.74 -0.39 1.22e-13 Mean corpuscular volume; LUSC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg21238619 chr17:78079768 GAA -0.29 -5.93 -0.31 7.53e-9 Yeast infection; LUSC cis rs9549260 0.577 rs6563841 chr13:41239178 A/C cg21288729 chr13:41239152 FOXO1 0.63 9.78 0.47 5.12e-20 Red blood cell count; LUSC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg03806693 chr22:41940476 POLR3H 0.99 13.71 0.6 3.01e-34 Vitiligo; LUSC cis rs10761482 0.813 rs4291629 chr10:62104758 C/T cg18175470 chr10:62150864 ANK3 -0.49 -7.08 -0.36 8.6e-12 Schizophrenia; LUSC cis rs10791323 0.536 rs1944731 chr11:133726067 G/A cg15485101 chr11:133734466 NA 0.4 7.43 0.38 8.9e-13 Childhood ear infection; LUSC cis rs7587476 0.601 rs17489363 chr2:215674341 A/G cg04004882 chr2:215674386 BARD1 -0.52 -7.27 -0.37 2.54e-12 Neuroblastoma; LUSC cis rs11105298 0.786 rs3803128 chr12:89860319 C/A cg00757033 chr12:89920650 WDR51B 0.6 10.33 0.49 7.01e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg20476274 chr7:133979776 SLC35B4 0.87 16.9 0.68 9.98e-47 Mean platelet volume; LUSC cis rs73200209 0.744 rs11612907 chr12:116495255 A/G cg01776926 chr12:116560359 MED13L -0.5 -5.94 -0.31 7.14e-9 Total body bone mineral density; LUSC cis rs12893668 0.667 rs11844466 chr14:104066422 G/A cg04998671 chr14:104000505 TRMT61A -0.42 -6.15 -0.32 2.17e-9 Reticulocyte count; LUSC cis rs733592 0.894 rs886589 chr12:48477197 C/T cg24011408 chr12:48396354 COL2A1 -0.44 -7.33 -0.37 1.7e-12 Plateletcrit; LUSC trans rs8072100 0.817 rs9912101 chr17:45547078 A/G cg04995722 chr7:26192034 NFE2L3 -0.43 -6.72 -0.35 8.08e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12681288 0.550 rs12675410 chr8:957845 T/C cg04851639 chr8:1020857 NA -0.35 -6.97 -0.36 1.67e-11 Schizophrenia; LUSC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg06637938 chr14:75390232 RPS6KL1 0.54 8.76 0.43 9.67e-17 Height; LUSC trans rs6549438 1.000 rs6798993 chr3:72161623 A/C cg12629250 chr15:20149347 NA -0.48 -6.17 -0.32 1.95e-9 Migraine - clinic-based; LUSC cis rs6728642 0.572 rs60621865 chr2:97598001 T/C cg26665480 chr2:98280029 ACTR1B -0.75 -7.48 -0.38 6.53e-13 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs7523050 0.730 rs12079547 chr1:109469314 A/C cg08274380 chr1:109419600 GPSM2 1.03 10.3 0.49 8.35e-22 Fat distribution (HIV); LUSC cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg05347473 chr6:146136440 FBXO30 0.56 9.72 0.47 8.14e-20 Lobe attachment (rater-scored or self-reported); LUSC trans rs4729127 1.000 rs8180725 chr7:94010953 G/C cg20086523 chr13:52378287 DHRS12 0.56 6.4 0.33 5.18e-10 Intelligence; LUSC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg04267008 chr7:1944627 MAD1L1 0.42 6.17 0.32 1.93e-9 Bipolar disorder and schizophrenia; LUSC cis rs6691722 0.506 rs11587667 chr1:24715435 C/G cg18323236 chr1:24743029 NIPAL3 0.39 6.7 0.34 9.02e-11 Response to interferon beta in multiple sclerosis; LUSC cis rs10193935 0.901 rs2374429 chr2:42677888 A/G cg27598129 chr2:42591480 NA -0.54 -8.21 -0.41 4.93e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs7989336 0.562 rs7323705 chr13:97029792 G/A cg02571835 chr13:96230311 CLDN10 -0.35 -5.66 -0.3 3.23e-8 Obesity; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg27588902 chr6:42928151 GNMT -0.27 -5.93 -0.31 7.5e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg03806693 chr22:41940476 POLR3H 1.02 14.1 0.61 9.48e-36 Vitiligo; LUSC trans rs7830939 1.000 rs7830939 chr8:9380132 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.59 -0.34 1.76e-10 Neuroticism; LUSC cis rs977987 0.806 rs11860284 chr16:75412907 A/G cg03315344 chr16:75512273 CHST6 0.49 9.33 0.45 1.46e-18 Dupuytren's disease; LUSC trans rs11165623 0.792 rs12132069 chr1:96918809 A/C cg10631902 chr5:14652156 NA -0.53 -8.75 -0.43 1.1e-16 Hip circumference;Waist circumference; LUSC cis rs7572644 0.699 rs10209126 chr2:28209283 C/T cg27432699 chr2:27873401 GPN1 -0.51 -6.95 -0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC trans rs61931739 0.963 rs12298565 chr12:34036188 C/T cg13010199 chr12:38710504 ALG10B -0.4 -6.01 -0.31 4.99e-9 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg14092988 chr3:52407081 DNAH1 0.3 5.8 0.3 1.53e-8 Bipolar disorder; LUSC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.89 -0.35 2.82e-11 Breast cancer; LUSC cis rs3796619 0.924 rs4690209 chr4:1077575 G/A cg27284194 chr4:1044797 NA 0.51 8.44 0.42 1e-15 Recombination rate (males); LUSC cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.1e-12 Motion sickness; LUSC cis rs7615316 0.779 rs2171035 chr3:142002786 C/T cg16271453 chr3:142027066 XRN1 -0.36 -6.33 -0.33 7.77e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9814567 1.000 rs12490835 chr3:134223730 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.71 -0.6 2.98e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9660992 0.626 rs9326600 chr1:205245268 G/A cg21545522 chr1:205238299 TMCC2 0.41 7.74 0.39 1.17e-13 Mean corpuscular volume;Mean platelet volume; LUSC cis rs1348850 0.958 rs1405713 chr2:178461560 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 5.93 0.31 7.38e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs8072100 0.713 rs4968318 chr17:45451894 G/A cg08085267 chr17:45401833 C17orf57 -0.49 -6.88 -0.35 2.94e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs62400317 0.762 rs3997499 chr6:44864552 G/T cg18551225 chr6:44695536 NA -0.46 -7.44 -0.38 8.7e-13 Total body bone mineral density; LUSC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg16434002 chr17:42200994 HDAC5 0.44 6.0 0.31 5.23e-9 Total body bone mineral density; LUSC cis rs9814567 1.000 rs1138273 chr3:134261437 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.68 -0.6 3.86e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7267979 0.966 rs2151144 chr20:25414924 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.69 -0.73 7.91e-58 Liver enzyme levels (alkaline phosphatase); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg02149193 chr12:132512069 EP400 -0.34 -5.94 -0.31 7.04e-9 N-glycan levels; LUSC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg17179660 chr6:151773299 C6orf211;RMND1 -0.46 -6.71 -0.34 8.44e-11 Menarche (age at onset); LUSC cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg23711669 chr6:146136114 FBXO30 0.88 16.39 0.67 1.06e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs754466 0.580 rs10824575 chr10:79549047 A/G cg17075019 chr10:79541650 NA -0.75 -11.9 -0.55 1.78e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs17608059 1.000 rs17608059 chr17:13910549 C/T cg11395062 chr17:14139857 CDRT15 0.4 6.35 0.33 6.87e-10 Temperament; LUSC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.08 0.4 1.19e-14 Parkinson's disease; LUSC cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg14584255 chr6:163149320 PACRG;PARK2 -0.36 -6.92 -0.35 2.38e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17102884 0.506 rs11845397 chr14:75404587 G/A cg11812906 chr14:75593930 NEK9 -0.41 -6.2 -0.32 1.63e-9 Neuroticism; LUSC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4891159 0.790 rs17059325 chr18:74119567 A/C cg24786174 chr18:74118243 ZNF516 -0.73 -12.23 -0.56 1.12e-28 Longevity; LUSC cis rs9362426 1.000 rs414013 chr6:88085866 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.39 6.19 0.32 1.8e-9 Depressive episodes in bipolar disorder; LUSC cis rs3960554 0.673 rs57358338 chr7:75732923 T/C cg17325771 chr7:75508891 RHBDD2 -0.4 -5.88 -0.31 9.71e-9 Eotaxin levels; LUSC cis rs477895 1.000 rs477895 chr11:64048912 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.57 -6.18 -0.32 1.87e-9 Mean platelet volume; LUSC cis rs1023500 0.505 rs2143139 chr22:42614401 G/C cg15557168 chr22:42548783 NA -0.43 -6.78 -0.35 5.59e-11 Schizophrenia; LUSC cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg05347473 chr6:146136440 FBXO30 0.48 8.01 0.4 1.89e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg27165867 chr14:105738592 BRF1 -0.54 -7.98 -0.4 2.45e-14 Mean platelet volume;Platelet distribution width; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg00945038 chr17:61921165 SMARCD2 -0.55 -9.47 -0.46 5.14e-19 Prudent dietary pattern; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.15e-9 Prudent dietary pattern; LUSC cis rs2921073 0.509 rs2976931 chr8:8257317 C/A cg06636001 chr8:8085503 FLJ10661 0.68 11.16 0.52 8.75e-25 Parkinson's disease; LUSC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.42 -8.88 -0.44 4.19e-17 Hemoglobin concentration; LUSC cis rs9650315 0.538 rs7833143 chr8:57208850 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.63 7.71 0.39 1.47e-13 Height; LUSC cis rs68170813 0.559 rs75203426 chr7:107017589 G/C cg02696742 chr7:106810147 HBP1 -0.64 -9.52 -0.46 3.73e-19 Coronary artery disease; LUSC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.74 9.16 0.45 5.4e-18 Schizophrenia; LUSC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.31 5.73 0.3 2.2e-8 Intelligence (multi-trait analysis); LUSC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg13939156 chr17:80058883 NA -0.34 -6.66 -0.34 1.16e-10 Life satisfaction; LUSC cis rs7524258 0.778 rs12028181 chr1:7315085 C/T cg07173049 chr1:7289937 CAMTA1 -0.31 -6.37 -0.33 6.39e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7267979 1.000 rs6050617 chr20:25421648 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12541635 0.966 rs10955409 chr8:107022586 A/C cg10147462 chr8:107024639 NA 0.52 9.64 0.47 1.46e-19 Age of smoking initiation; LUSC cis rs7208859 0.623 rs8068645 chr17:29104342 T/A cg13385521 chr17:29058706 SUZ12P 0.68 6.74 0.35 7.03e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg18512352 chr11:47633146 NA -0.47 -9.56 -0.46 2.72e-19 Subjective well-being; LUSC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg25039879 chr17:56429692 SUPT4H1 0.69 9.08 0.44 9.99e-18 Cognitive test performance; LUSC cis rs8017423 0.935 rs17188598 chr14:90722473 A/T cg04374321 chr14:90722782 PSMC1 0.74 12.09 0.55 3.76e-28 Mortality in heart failure; LUSC cis rs9326248 0.689 rs236916 chr11:117089628 G/A cg26566898 chr11:117069891 TAGLN -0.43 -6.2 -0.32 1.63e-9 Blood protein levels; LUSC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.66 0.3 3.24e-8 Cerebrospinal P-tau181p levels; LUSC cis rs981844 0.961 rs6827685 chr4:154662227 C/T cg14289246 chr4:154710475 SFRP2 0.46 5.8 0.3 1.54e-8 Response to statins (LDL cholesterol change); LUSC cis rs710216 0.843 rs2297972 chr1:43418026 C/T cg03128534 chr1:43423976 SLC2A1 -0.51 -6.63 -0.34 1.36e-10 Red cell distribution width; LUSC cis rs5769765 0.908 rs7410318 chr22:50317049 T/C cg08270630 chr22:50330655 NA -0.45 -6.64 -0.34 1.3e-10 Schizophrenia; LUSC cis rs11190604 1.000 rs11292 chr10:102313607 A/G cg07080220 chr10:102295463 HIF1AN 0.63 8.63 0.43 2.49e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11583043 0.918 rs6693456 chr1:101424561 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.47 6.56 0.34 2.09e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC trans rs2840044 1.000 rs225304 chr17:33921857 G/T cg19694781 chr19:47549865 TMEM160 -0.59 -9.43 -0.46 7.14e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs6496667 0.557 rs2601201 chr15:90958000 C/T cg10434728 chr15:90938212 IQGAP1 0.32 5.98 0.31 5.58e-9 Rheumatoid arthritis; LUSC cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg03264133 chr6:25882463 NA -0.5 -9.23 -0.45 3.21e-18 Blood metabolite levels; LUSC cis rs17767294 0.522 rs78037434 chr6:27848898 A/T cg08851530 chr6:28072375 NA 1.18 7.81 0.39 7.25e-14 Parkinson's disease; LUSC cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg24692254 chr21:30365293 RNF160 0.71 11.53 0.53 3.91e-26 Pancreatic cancer; LUSC trans rs57221529 0.766 rs72703070 chr5:590458 T/C cg11887960 chr12:57824829 NA 0.55 6.69 0.34 9.64e-11 Lung disease severity in cystic fibrosis; LUSC cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -8.96 -0.44 2.38e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg20608306 chr11:116969690 SIK3 -0.38 -6.34 -0.33 7.56e-10 Blood protein levels; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg22963979 chr7:1858916 MAD1L1 -0.7 -11.75 -0.54 6.52e-27 Bipolar disorder and schizophrenia; LUSC cis rs9527 0.590 rs2066322 chr10:104909339 T/G cg04362960 chr10:104952993 NT5C2 0.62 9.65 0.47 1.35e-19 Arsenic metabolism; LUSC cis rs4363385 0.550 rs6661932 chr1:152896734 T/C cg00922841 chr1:152955080 SPRR1A -0.39 -6.33 -0.33 7.87e-10 Inflammatory skin disease; LUSC cis rs295140 0.903 rs10931898 chr2:201171191 C/G cg04283868 chr2:201171347 SPATS2L 0.43 6.45 0.33 3.85e-10 QT interval; LUSC cis rs8114671 0.901 rs6119581 chr20:33773689 T/A cg07148914 chr20:33460835 GGT7 0.46 6.84 0.35 3.87e-11 Height; LUSC cis rs6977660 1.000 rs12672557 chr7:19804237 G/A cg05791153 chr7:19748676 TWISTNB 0.58 6.43 0.33 4.34e-10 Thyroid stimulating hormone; LUSC cis rs59698941 0.550 rs11748737 chr5:132201070 C/T cg14825688 chr5:132208181 LEAP2 -0.43 -6.41 -0.33 4.95e-10 Apolipoprotein A-IV levels; LUSC cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg00278107 chr5:1061253 SLC12A7 -0.76 -12.96 -0.58 2.15e-31 QT interval; LUSC cis rs13064411 0.696 rs2087129 chr3:113142769 T/A cg18753928 chr3:113234510 CCDC52 -0.44 -6.68 -0.34 9.9e-11 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs6920965 0.545 rs2326242 chr6:126174859 A/C cg05901451 chr6:126070800 HEY2 -0.39 -5.65 -0.3 3.48e-8 High light scatter reticulocyte count; LUSC cis rs561341 0.710 rs9900031 chr17:30199537 T/C cg00745463 chr17:30367425 LRRC37B 0.78 8.21 0.41 4.91e-15 Hip circumference adjusted for BMI; LUSC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg21782813 chr7:2030301 MAD1L1 0.49 8.24 0.41 3.92e-15 Bipolar disorder and schizophrenia; LUSC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg03060546 chr3:49711283 APEH 0.5 6.74 0.35 6.97e-11 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs4654899 0.897 rs6679753 chr1:21066634 G/C cg01072550 chr1:21505969 NA -0.47 -7.06 -0.36 9.47e-12 Superior frontal gyrus grey matter volume; LUSC cis rs12801636 0.846 rs1078457 chr11:65380124 C/T cg27068330 chr11:65405492 SIPA1 0.57 6.29 0.33 1.02e-9 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg12292205 chr6:26970375 C6orf41 -0.56 -7.39 -0.37 1.18e-12 Intelligence (multi-trait analysis); LUSC cis rs6964587 1.000 rs12533199 chr7:91757393 C/T cg17063962 chr7:91808500 NA 0.6 9.43 0.46 7.09e-19 Breast cancer; LUSC cis rs9311676 0.632 rs62259772 chr3:58417416 C/T cg13750441 chr3:58318267 PXK 0.35 6.83 0.35 4.14e-11 Systemic lupus erythematosus; LUSC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg08219700 chr8:58056026 NA 0.5 6.25 0.32 1.27e-9 Developmental language disorder (linguistic errors); LUSC cis rs12493885 0.725 rs57740056 chr3:153744530 A/C cg17054900 chr3:154042577 DHX36 -0.55 -6.02 -0.31 4.59e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6987853 0.933 rs1343875 chr8:42424749 C/T cg09913449 chr8:42400586 C8orf40 0.48 8.02 0.4 1.77e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg10523679 chr1:76189770 ACADM 0.9 16.2 0.66 5.81e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.8 -0.35 4.9e-11 Lung cancer; LUSC cis rs427941 0.632 rs201504 chr7:101759878 C/G cg06246474 chr7:101738831 CUX1 0.38 6.34 0.33 7.32e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs61931739 0.517 rs7139189 chr12:34319757 T/C cg06521331 chr12:34319734 NA -0.53 -9.23 -0.45 3.08e-18 Morning vs. evening chronotype; LUSC cis rs1557765 0.527 rs11024272 chr11:17395760 T/C cg15432903 chr11:17409602 KCNJ11 0.45 7.82 0.39 6.88e-14 Body mass index;Social communication problems; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg19318889 chr4:1322082 MAEA 0.44 7.27 0.37 2.49e-12 Obesity-related traits; LUSC cis rs9467773 1.000 rs6926629 chr6:26499903 T/C cg09904177 chr6:26538194 HMGN4 0.72 13.02 0.58 1.28e-31 Intelligence (multi-trait analysis); LUSC cis rs11608355 0.515 rs7311488 chr12:109930905 C/G cg05360138 chr12:110035743 NA -0.9 -12.17 -0.55 1.95e-28 Neuroticism; LUSC cis rs7267979 1.000 rs2500436 chr20:25406366 G/C cg03522245 chr20:25566470 NINL -0.35 -5.72 -0.3 2.36e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg25258033 chr6:167368657 RNASET2 0.39 6.3 0.33 9.49e-10 Crohn's disease; LUSC cis rs2414856 0.510 rs10400921 chr15:64661937 C/T cg08069370 chr15:64387884 SNX1 -0.74 -6.48 -0.33 3.34e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg25036284 chr2:26402008 FAM59B 0.7 9.36 0.46 1.19e-18 Gut microbiome composition (summer); LUSC cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.97 -0.4 2.55e-14 Schizophrenia; LUSC cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg19812747 chr11:111475976 SIK2 0.5 6.7 0.34 8.87e-11 Primary sclerosing cholangitis; LUSC cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg16482183 chr6:26056742 HIST1H1C 0.47 6.9 0.35 2.61e-11 Height; LUSC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg17971929 chr21:40555470 PSMG1 0.8 14.27 0.62 2.18e-36 Cognitive function; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg22709601 chr15:67408553 SMAD3 0.46 6.2 0.32 1.64e-9 Cognitive function;Information processing speed; LUSC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg11584989 chr19:19387371 SF4 -0.62 -7.14 -0.36 5.8e-12 Bipolar disorder; LUSC cis rs8056893 0.686 rs3826167 chr16:68397530 T/G cg02226672 chr16:68398533 SMPD3 0.32 5.72 0.3 2.32e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs6089829 0.962 rs6011544 chr20:61658782 T/C cg08564027 chr20:61660810 NA 0.93 17.11 0.68 1.47e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs3960554 0.808 rs868555 chr7:75697418 G/A cg17325771 chr7:75508891 RHBDD2 -0.4 -5.68 -0.3 2.87e-8 Eotaxin levels; LUSC cis rs6722750 0.506 rs12612392 chr2:64373635 G/A cg22352474 chr2:64371530 PELI1 0.68 10.54 0.5 1.27e-22 Neuroticism; LUSC cis rs17034641 0.744 rs2053797 chr2:46370892 C/T cg12428440 chr2:46370979 PRKCE 0.51 7.67 0.39 1.9e-13 Hemoglobin;Hematocrit; LUSC cis rs1595825 0.945 rs76510735 chr2:198823095 G/A cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 6.08e-9 Ulcerative colitis; LUSC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.82 0.39 7.14e-14 Electroencephalogram traits; LUSC cis rs10883723 0.962 rs1056741 chr10:104236640 A/C cg05855489 chr10:104503620 C10orf26 -0.72 -10.16 -0.49 2.64e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg20933634 chr6:27740509 NA 0.41 5.76 0.3 1.94e-8 Parkinson's disease; LUSC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.65 0.39 2.2e-13 Crohn's disease; LUSC cis rs7772486 0.902 rs2748500 chr6:146314852 C/A cg23711669 chr6:146136114 FBXO30 0.77 13.37 0.59 6.01e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs1881396 0.947 rs10173720 chr2:27855397 A/T cg27432699 chr2:27873401 GPN1 -0.66 -8.71 -0.43 1.48e-16 Nonalcoholic fatty liver disease; LUSC cis rs7523050 0.643 rs71655970 chr1:109403895 A/G cg08274380 chr1:109419600 GPSM2 1.1 10.67 0.5 4.47e-23 Fat distribution (HIV); LUSC cis rs6987853 0.623 rs10109400 chr8:42455353 T/C cg09913449 chr8:42400586 C8orf40 0.44 7.42 0.38 9.89e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs10782582 0.609 rs1770889 chr1:76401166 A/G cg10523679 chr1:76189770 ACADM -0.44 -6.44 -0.33 4.11e-10 Daytime sleep phenotypes; LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg06873352 chr17:61820015 STRADA 0.76 13.69 0.6 3.45e-34 Prudent dietary pattern; LUSC cis rs76878669 0.561 rs6591217 chr11:66174653 G/A cg24851651 chr11:66362959 CCS 0.39 6.14 0.32 2.37e-9 Educational attainment (years of education); LUSC cis rs2274273 0.638 rs3759667 chr14:55658421 A/G cg04306507 chr14:55594613 LGALS3 0.49 9.76 0.47 5.85e-20 Protein biomarker; LUSC cis rs2274273 0.588 rs2880103 chr14:55737832 A/C cg04306507 chr14:55594613 LGALS3 0.49 9.81 0.47 4.08e-20 Protein biomarker; LUSC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.86 -12.63 -0.57 3.67e-30 Multiple sclerosis; LUSC cis rs11209185 0.509 rs1926279 chr1:68450681 A/G cg22082780 chr1:68452167 NA 0.42 7.19 0.37 4.2e-12 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg05368731 chr17:41323189 NBR1 0.93 16.18 0.66 6.77e-44 Menopause (age at onset); LUSC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg06108461 chr20:60628389 TAF4 -1.01 -17.18 -0.68 7.43e-48 Body mass index; LUSC cis rs9814567 1.000 rs9883753 chr3:134247231 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.25 -0.59 1.75e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs11608355 1.000 rs3742020 chr12:109883254 T/C cg05360138 chr12:110035743 NA 0.45 6.25 0.32 1.23e-9 Neuroticism; LUSC cis rs11971779 0.680 rs4732379 chr7:139122814 T/C cg23387468 chr7:139079360 LUC7L2 0.38 5.73 0.3 2.19e-8 Diisocyanate-induced asthma; LUSC cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg12011299 chr4:100065546 ADH4 -0.81 -13.29 -0.59 1.2e-32 Alcohol dependence; LUSC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg20887711 chr4:1340912 KIAA1530 0.47 7.15 0.36 5.57e-12 Obesity-related traits; LUSC cis rs12618769 0.601 rs56118505 chr2:99139832 T/G cg10123293 chr2:99228465 UNC50 0.45 7.42 0.38 9.52e-13 Bipolar disorder; LUSC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg26335602 chr6:28129616 ZNF389 0.44 5.88 0.31 9.91e-9 Parkinson's disease; LUSC cis rs6964587 1.000 rs2285333 chr7:91667692 T/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.23e-8 Breast cancer; LUSC cis rs5758511 0.680 rs34107327 chr22:42648353 T/G cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.94 -0.31 7.2e-9 Birth weight; LUSC trans rs8072100 0.967 rs62076549 chr17:45579555 T/G cg04995722 chr7:26192034 NFE2L3 0.37 6.03 0.31 4.35e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg09904177 chr6:26538194 HMGN4 -0.53 -6.21 -0.32 1.57e-9 Intelligence (multi-trait analysis); LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg25703541 chr22:24373054 LOC391322 0.83 10.23 0.49 1.52e-21 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs1832871 0.711 rs9459829 chr6:158680799 C/T cg07165851 chr6:158734300 TULP4 0.51 7.87 0.4 4.91e-14 Height; LUSC cis rs6840360 0.615 rs3828546 chr4:152679816 A/G cg22705602 chr4:152727874 NA -0.34 -7.58 -0.38 3.36e-13 Intelligence (multi-trait analysis); LUSC cis rs4964805 0.549 rs11111752 chr12:104156552 C/T cg02344784 chr12:104178138 NT5DC3 0.41 6.47 0.33 3.42e-10 Attention deficit hyperactivity disorder; LUSC cis rs427941 0.632 rs201527 chr7:101774451 T/C cg06246474 chr7:101738831 CUX1 0.38 6.14 0.32 2.34e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4148883 0.675 rs10015824 chr4:100074544 C/G cg12011299 chr4:100065546 ADH4 0.48 7.88 0.4 4.78e-14 Alcohol dependence; LUSC cis rs2281558 0.517 rs16987966 chr20:25643414 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.53 6.39 0.33 5.49e-10 Peripheral arterial disease (traffic-related air pollution interaction);Calcium levels; LUSC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg12560992 chr17:57184187 TRIM37 0.86 15.46 0.65 5e-41 Intelligence (multi-trait analysis); LUSC cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg26314531 chr2:26401878 FAM59B 0.73 10.05 0.48 6.09e-21 Gut microbiome composition (summer); LUSC cis rs67696533 0.636 rs910889 chr20:31104950 T/C cg13636640 chr20:31349939 DNMT3B 0.45 6.21 0.32 1.62e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs7582720 1.000 rs115953525 chr2:203744445 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.69 0.43 1.7e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs853679 0.542 rs34131763 chr6:28075000 A/C cg06606381 chr12:133084897 FBRSL1 -0.47 -6.11 -0.32 2.77e-9 Depression; LUSC cis rs7795096 0.743 rs9648730 chr7:151537785 G/A cg17008978 chr7:151542804 PRKAG2 0.34 6.53 0.34 2.44e-10 Bipolar disorder (age of onset and psychotic symptoms); LUSC cis rs709400 0.627 rs62007686 chr14:103899344 A/G cg24130564 chr14:104152367 KLC1 -0.46 -6.34 -0.33 7.27e-10 Body mass index; LUSC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg26513180 chr16:89883248 FANCA 0.91 17.74 0.7 4.55e-50 Vitiligo; LUSC cis rs765787 0.530 rs2413780 chr15:45538866 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs698813 0.763 rs786614 chr2:44590567 C/G cg00619915 chr2:44497795 NA -0.42 -6.01 -0.31 4.75e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -16.46 -0.67 5.61e-45 Primary sclerosing cholangitis; LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg04267008 chr7:1944627 MAD1L1 0.68 10.57 0.5 1.03e-22 Bipolar disorder and schizophrenia; LUSC cis rs1178968 0.688 rs2528708 chr7:72788583 C/A cg25889504 chr7:72793014 NA 0.59 7.63 0.39 2.52e-13 Triglyceride levels; LUSC cis rs8060686 0.516 rs13339471 chr16:68253008 A/G cg09835421 chr16:68378352 PRMT7 -0.47 -5.78 -0.3 1.69e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs8060686 0.516 rs7189794 chr16:68277727 T/C cg05110241 chr16:68378359 PRMT7 -0.53 -6.55 -0.34 2.19e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9929218 0.954 rs7199991 chr16:68818245 T/G cg02972257 chr16:68554789 NA 0.43 5.93 0.31 7.62e-9 Colorectal cancer; LUSC cis rs2073300 1.000 rs59283536 chr20:23457575 A/T cg09953122 chr20:23471693 CST8 -0.69 -6.86 -0.35 3.28e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9660992 0.542 rs17345153 chr1:205179997 A/G cg03948781 chr1:205179583 DSTYK 0.33 6.24 0.32 1.32e-9 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7267979 1.000 rs4813562 chr20:25352588 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.34 -0.74 2.17e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12188164 0.932 rs2230437 chr5:476353 C/T cg16584290 chr5:462447 EXOC3 -0.39 -6.94 -0.36 2.02e-11 Cystic fibrosis severity; LUSC cis rs7107174 1.000 rs2512542 chr11:77981780 G/A cg02023728 chr11:77925099 USP35 0.44 6.67 0.34 1.05e-10 Testicular germ cell tumor; LUSC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg08677398 chr8:58056175 NA 0.53 6.91 0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs6582630 0.576 rs4882258 chr12:38453686 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.48 -0.33 3.36e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs1372520 0.684 rs2572318 chr4:90718719 C/T cg15133208 chr4:90757351 SNCA -0.52 -8.17 -0.41 6.42e-15 Neuroticism; LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.96 0.61 3.35e-35 Platelet count; LUSC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg16423285 chr20:60520624 NA -0.48 -6.01 -0.31 4.98e-9 Body mass index; LUSC cis rs9865818 0.702 rs4686483 chr3:188118225 T/A cg23651889 chr3:188115336 LPP -0.39 -5.92 -0.31 8.09e-9 Allergic sensitization; LUSC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg16434002 chr17:42200994 HDAC5 -0.46 -6.44 -0.33 4.27e-10 Total body bone mineral density; LUSC cis rs2282300 0.739 rs1933342 chr11:30312825 C/T cg25418670 chr11:30344373 C11orf46 0.64 9.21 0.45 3.67e-18 Morning vs. evening chronotype; LUSC cis rs6500395 0.926 rs11076572 chr16:48623621 T/G cg04672837 chr16:48644449 N4BP1 0.49 7.02 0.36 1.26e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6840360 0.967 rs1105534 chr4:152605312 C/A cg22705602 chr4:152727874 NA -0.28 -5.88 -0.31 9.85e-9 Intelligence (multi-trait analysis); LUSC cis rs3859192 0.599 rs2302777 chr17:38179492 A/G cg17467752 chr17:38218738 THRA -0.49 -6.95 -0.36 1.87e-11 White blood cell count; LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg06600287 chr1:53387719 ECHDC2 -0.31 -6.54 -0.34 2.29e-10 Monocyte count; LUSC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23221052 chr5:179740743 GFPT2 -0.62 -10.01 -0.48 8.17e-21 Height; LUSC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.42 -7.44 -0.38 8.53e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs1551570 0.819 rs11666402 chr19:10219076 A/G cg16327482 chr19:10226339 EIF3G 0.37 7.11 0.36 6.96e-12 Narcolepsy; LUSC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg05368731 chr17:41323189 NBR1 0.84 14.04 0.61 1.65e-35 Menopause (age at onset); LUSC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg25039879 chr17:56429692 SUPT4H1 0.72 9.82 0.47 3.63e-20 Cognitive test performance; LUSC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg14500267 chr11:67383377 NA -0.43 -8.45 -0.42 8.87e-16 Mean corpuscular volume; LUSC cis rs13082711 0.911 rs67104968 chr3:27510304 A/G cg02860705 chr3:27208620 NA 0.47 7.96 0.4 2.67e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg15445000 chr17:37608096 MED1 0.4 6.92 0.35 2.26e-11 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg12463550 chr7:65579703 CRCP -0.47 -6.7 -0.34 8.75e-11 Aortic root size; LUSC cis rs5758511 0.689 rs11913578 chr22:42347391 A/C cg12850546 chr22:42539477 CYP2D7P1 -0.49 -6.02 -0.31 4.65e-9 Birth weight; LUSC cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg23788917 chr6:8435910 SLC35B3 0.51 7.56 0.38 4.03e-13 Motion sickness; LUSC cis rs10498514 0.590 rs117242159 chr14:65045360 G/A cg25134081 chr14:64931936 AKAP5 0.98 7.11 0.36 7.11e-12 Cognitive performance; LUSC cis rs9457247 0.510 rs6456151 chr6:167471851 A/C cg07741184 chr6:167504864 NA 0.39 6.88 0.35 2.9e-11 Crohn's disease; LUSC cis rs3091242 0.866 rs11249249 chr1:25758134 A/G cg20684491 chr1:25596433 NA 0.38 5.92 0.31 7.97e-9 Erythrocyte sedimentation rate; LUSC cis rs950169 0.922 rs4842939 chr15:84827966 C/T cg17173187 chr15:85201210 NMB -0.31 -6.1 -0.32 2.91e-9 Schizophrenia; LUSC cis rs4343996 0.650 rs10274594 chr7:3463561 T/G cg21248987 chr7:3385318 SDK1 0.35 5.84 0.3 1.21e-8 Motion sickness; LUSC cis rs2439831 0.867 rs2447196 chr15:43893818 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.67 -6.65 -0.34 1.2e-10 Lung cancer in ever smokers; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg14893161 chr1:205819251 PM20D1 0.94 18.91 0.72 9.99e-55 Menarche (age at onset); LUSC cis rs2197308 0.765 rs12230545 chr12:37927114 C/T cg26384229 chr12:38710491 ALG10B -0.83 -13.99 -0.61 2.61e-35 Morning vs. evening chronotype; LUSC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg12463550 chr7:65579703 CRCP 0.45 6.65 0.34 1.23e-10 Aortic root size; LUSC cis rs9309473 0.514 rs62149630 chr2:73581755 C/G cg20560298 chr2:73613845 ALMS1 -0.51 -5.98 -0.31 5.79e-9 Metabolite levels; LUSC cis rs7903847 0.642 rs7074511 chr10:99140177 G/A cg08345082 chr10:99160200 RRP12 -0.37 -7.46 -0.38 7.46e-13 Granulocyte percentage of myeloid white cells; LUSC cis rs854765 0.624 rs4925116 chr17:17731200 A/G cg04398451 chr17:18023971 MYO15A 0.4 6.24 0.32 1.36e-9 Total body bone mineral density; LUSC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC trans rs9886428 1.000 rs10099853 chr8:14115675 G/C cg19037007 chr20:741798 C20orf54 -0.39 -6.11 -0.32 2.77e-9 IgG glycosylation; LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg03188948 chr7:1209495 NA 0.66 7.02 0.36 1.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg22868518 chr11:507468 RNH1 -0.6 -5.94 -0.31 7.19e-9 Body mass index; LUSC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg03354898 chr7:1950403 MAD1L1 -0.34 -6.55 -0.34 2.2e-10 Schizophrenia; LUSC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs12541635 1.000 rs1366969 chr8:107092851 A/T cg10147462 chr8:107024639 NA -0.47 -8.64 -0.43 2.37e-16 Age of smoking initiation; LUSC cis rs17270561 0.666 rs1937129 chr6:25789132 A/G cg17691542 chr6:26056736 HIST1H1C 0.48 6.88 0.35 3.02e-11 Iron status biomarkers; LUSC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg21361702 chr7:150065534 REPIN1 0.59 8.57 0.42 3.96e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg08888203 chr3:10149979 C3orf24 0.63 9.09 0.45 8.92e-18 Alzheimer's disease; LUSC cis rs4014195 0.521 rs12576996 chr11:65580638 G/T cg05805236 chr11:65401703 PCNXL3 0.46 6.48 0.33 3.2e-10 Glomerular filtration rate (creatinine);Chronic kidney disease; LUSC cis rs500891 0.620 rs1034260 chr6:84162873 T/C cg08257003 chr6:84140564 ME1 0.37 9.06 0.44 1.1e-17 Platelet-derived growth factor BB levels; LUSC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg27432699 chr2:27873401 GPN1 -0.59 -8.76 -0.43 1e-16 Menopause (age at onset); LUSC cis rs4663969 0.873 rs759174 chr2:234668245 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -7.15 -0.36 5.59e-12 Total bilirubin levels in HIV-1 infection; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg08539889 chr16:71496259 ZNF23 0.42 5.96 0.31 6.44e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg20848291 chr7:100343083 ZAN -0.65 -8.46 -0.42 8.42e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7100689 0.646 rs11202751 chr10:82147802 G/A cg00277334 chr10:82204260 NA -0.5 -7.28 -0.37 2.37e-12 Post bronchodilator FEV1; LUSC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg24829409 chr8:58192753 C8orf71 0.55 5.9 0.31 8.96e-9 Developmental language disorder (linguistic errors); LUSC cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg00152838 chr16:24741724 TNRC6A -0.46 -5.71 -0.3 2.55e-8 Intelligence (multi-trait analysis); LUSC cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.85 12.67 0.57 2.64e-30 Cognitive ability; LUSC cis rs4851254 0.618 rs4851243 chr2:100639482 G/A cg22139774 chr2:100720529 AFF3 -0.45 -5.91 -0.31 8.36e-9 Intelligence (multi-trait analysis); LUSC cis rs35883536 0.588 rs17403878 chr1:101105310 C/T cg06223162 chr1:101003688 GPR88 0.35 6.01 0.31 4.92e-9 Monocyte count; LUSC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg17443473 chr1:3703550 LRRC47 0.34 5.89 0.31 9.5e-9 Red cell distribution width; LUSC cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.05e-43 Bladder cancer; LUSC cis rs6545883 0.931 rs7557230 chr2:61736652 A/T cg15711740 chr2:61764176 XPO1 -0.5 -7.98 -0.4 2.31e-14 Tuberculosis; LUSC cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.69 8.05 0.4 1.46e-14 Lung function (FEV1/FVC); LUSC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg09035930 chr12:129282057 SLC15A4 0.67 13.45 0.59 3.02e-33 Systemic lupus erythematosus; LUSC cis rs11677416 1.000 rs1800794 chr2:113543273 G/A cg27083787 chr2:113543245 IL1A 0.51 7.92 0.4 3.52e-14 Response to antipsychotic treatment in schizophrenia (working memory); LUSC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg22800045 chr5:56110881 MAP3K1 0.77 9.91 0.48 1.87e-20 Initial pursuit acceleration; LUSC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg13372766 chr1:228464049 OBSCN 0.33 6.24 0.32 1.31e-9 Diastolic blood pressure; LUSC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg21644426 chr2:191273491 MFSD6 0.61 9.72 0.47 7.83e-20 Pulse pressure; LUSC cis rs4631830 0.863 rs4554834 chr10:51530146 A/C cg16070123 chr10:51489643 NA -0.5 -7.96 -0.4 2.78e-14 Prostate-specific antigen levels; LUSC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg13390004 chr1:15929781 NA 0.4 6.7 0.34 9.07e-11 Systolic blood pressure; LUSC cis rs6933660 0.800 rs3800273 chr6:151759035 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.48 7.54 0.38 4.59e-13 Menarche (age at onset); LUSC cis rs2073300 1.000 rs114718317 chr20:23442620 T/C cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06117184 chr2:113522207 CKAP2L 0.4 6.79 0.35 5.09e-11 Triglycerides; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.5 -8.39 -0.42 1.35e-15 Lymphocyte counts; LUSC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs75804782 0.521 rs72993073 chr2:239412925 G/A cg18131467 chr2:239335373 ASB1 -0.71 -6.29 -0.33 9.82e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs1348850 1.000 rs3927978 chr2:178443854 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.5 -6.77 -0.35 5.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4889855 0.530 rs8079792 chr17:78609394 A/G cg16591659 chr17:78472290 NA -0.33 -5.82 -0.3 1.37e-8 Fractional excretion of uric acid; LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg24060327 chr5:131705240 SLC22A5 -0.53 -8.22 -0.41 4.42e-15 Acylcarnitine levels; LUSC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg18681998 chr4:17616180 MED28 0.83 15.93 0.66 6.53e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17548431 chr4:160024475 NA -0.48 -6.44 -0.33 4.06e-10 Bipolar disorder and schizophrenia; LUSC cis rs11971779 0.680 rs7792752 chr7:139066196 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg27432699 chr2:27873401 GPN1 -0.57 -8.45 -0.42 9.15e-16 Total body bone mineral density; LUSC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.4 5.67 0.3 3.1e-8 Schizophrenia; LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg08280861 chr8:58055591 NA 0.55 6.58 0.34 1.79e-10 Developmental language disorder (linguistic errors); LUSC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg27170947 chr2:26402098 FAM59B -0.62 -9.17 -0.45 4.9e-18 Gut microbiome composition (summer); LUSC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.26 0.52 3.89e-25 Menopause (age at onset); LUSC cis rs6495122 0.501 rs12904227 chr15:75387048 A/C cg14664628 chr15:75095509 CSK 0.43 6.28 0.32 1.08e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs6456156 0.586 rs9457266 chr6:167482555 T/C cg06454157 chr6:167490870 NA -0.28 -6.71 -0.34 8.57e-11 Primary biliary cholangitis; LUSC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg02569458 chr12:86230093 RASSF9 0.49 8.22 0.41 4.69e-15 Major depressive disorder; LUSC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg25703541 chr22:24373054 LOC391322 0.98 18.03 0.7 3.08e-51 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6977660 0.652 rs10254427 chr7:19816240 C/T cg07541023 chr7:19748670 TWISTNB 0.58 6.49 0.33 3.14e-10 Thyroid stimulating hormone; LUSC cis rs11190604 1.000 rs2295780 chr10:102305965 A/G cg07080220 chr10:102295463 HIF1AN 0.69 8.89 0.44 3.81e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs62408225 1.000 rs943689 chr6:90984035 C/T cg06866423 chr6:90926672 BACH2 0.41 5.91 0.31 8.67e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9388451 0.839 rs1811852 chr6:126071575 G/C cg10911889 chr6:126070802 HEY2 0.43 6.54 0.34 2.28e-10 Brugada syndrome; LUSC cis rs748404 0.587 rs690276 chr15:43704558 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.41 5.83 0.3 1.28e-8 Lung cancer; LUSC cis rs9788682 0.748 rs637137 chr15:78873976 T/A cg06917634 chr15:78832804 PSMA4 -0.52 -6.51 -0.34 2.68e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.49 -7.13 -0.36 6.33e-12 Alzheimer's disease (late onset); LUSC cis rs4888262 0.545 rs58136167 chr16:74700628 G/A cg05580060 chr16:74700937 RFWD3 0.41 5.76 0.3 1.95e-8 Testicular germ cell tumor; LUSC cis rs6084875 0.840 rs1999665 chr20:4720988 C/T cg26097573 chr20:4721490 PRNT -0.31 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus; LUSC cis rs61931739 0.517 rs2636073 chr12:34063049 C/T cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.09e-15 Morning vs. evening chronotype; LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.0 14.83 0.63 1.46e-38 Platelet count; LUSC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg06634786 chr22:41940651 POLR3H 0.5 6.04 0.31 4.07e-9 Vitiligo; LUSC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg08219700 chr8:58056026 NA 0.63 8.08 0.4 1.22e-14 Developmental language disorder (linguistic errors); LUSC cis rs7177699 0.534 rs4387568 chr15:79109514 C/G cg15571903 chr15:79123663 NA -0.34 -6.27 -0.32 1.13e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg04546413 chr19:29218101 NA 0.63 7.93 0.4 3.39e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg05738196 chr6:26577821 NA -0.58 -6.79 -0.35 5.04e-11 Intelligence (multi-trait analysis); LUSC cis rs2455601 0.507 rs7948452 chr11:8877704 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -7.69 -0.39 1.68e-13 Schizophrenia; LUSC cis rs9303401 0.614 rs2333409 chr17:57139134 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.81 12.04 0.55 5.42e-28 Cognitive test performance; LUSC cis rs61931739 0.517 rs7960878 chr12:34055645 C/A cg06521331 chr12:34319734 NA -0.47 -7.63 -0.39 2.42e-13 Morning vs. evening chronotype; LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg24813613 chr7:1882135 MAD1L1 -0.39 -6.41 -0.33 4.89e-10 Bipolar disorder and schizophrenia; LUSC cis rs17095355 1.000 rs12570145 chr10:111712913 A/G cg00817464 chr10:111662876 XPNPEP1 -0.68 -7.87 -0.4 4.85e-14 Biliary atresia; LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.524 rs7929725 chr11:47881740 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.76 0.35 6.07e-11 Subjective well-being; LUSC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg14552801 chr7:65878734 NA -0.43 -6.16 -0.32 2.05e-9 Aortic root size; LUSC trans rs3733585 0.605 rs4697710 chr4:10122649 T/C cg26043149 chr18:55253948 FECH -0.52 -7.6 -0.38 3e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs6502050 0.799 rs6502066 chr17:80103737 T/C cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs4664308 0.870 rs2198918 chr2:161015052 C/T cg03641300 chr2:160917029 PLA2R1 -0.64 -10.92 -0.51 6.16e-24 Idiopathic membranous nephropathy; LUSC cis rs4332037 0.510 rs11762803 chr7:1886805 A/G cg12432903 chr7:1882776 MAD1L1 0.45 6.12 0.32 2.66e-9 Bipolar disorder; LUSC cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.7 9.43 0.46 7.25e-19 Chronic sinus infection; LUSC cis rs6840360 0.571 rs62327277 chr4:152555905 C/T cg22705602 chr4:152727874 NA -0.31 -6.21 -0.32 1.53e-9 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13024018 chr3:133380790 TOPBP1 -0.42 -6.07 -0.32 3.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg27170947 chr2:26402098 FAM59B -0.63 -9.1 -0.45 8.18e-18 Gut microbiome composition (summer); LUSC cis rs7107174 1.000 rs2510049 chr11:77985459 G/T cg02023728 chr11:77925099 USP35 0.48 6.82 0.35 4.26e-11 Testicular germ cell tumor; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11327809 chr8:101965577 YWHAZ 0.43 6.27 0.32 1.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11785400 0.793 rs4430071 chr8:143737680 T/C cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC cis rs55910451 0.779 rs72774070 chr10:5760199 A/G cg11519256 chr10:5708881 ASB13 -0.48 -5.85 -0.3 1.19e-8 Breast cancer; LUSC cis rs35146811 0.735 rs6948729 chr7:99787372 A/G cg22906224 chr7:99728672 NA 0.47 6.54 0.34 2.36e-10 Coronary artery disease; LUSC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg03433033 chr1:76189801 ACADM -0.81 -12.91 -0.58 3.31e-31 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9479482 0.967 rs763574 chr6:150349415 G/C cg25797454 chr6:150327115 RAET1K 0.35 7.93 0.4 3.32e-14 Alopecia areata; LUSC trans rs12478296 0.786 rs13409307 chr2:242995499 G/C cg01596870 chr19:55963115 NA -0.51 -5.99 -0.31 5.34e-9 Obesity-related traits; LUSC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg17143192 chr8:8559678 CLDN23 0.66 9.55 0.46 2.97e-19 Obesity-related traits; LUSC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg21724239 chr8:58056113 NA 0.62 7.07 0.36 9.3e-12 Developmental language disorder (linguistic errors); LUSC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg17279839 chr7:150038598 RARRES2 0.55 8.13 0.41 8.65e-15 Blood protein levels;Circulating chemerin levels; LUSC cis rs7264396 1.000 rs224437 chr20:34154371 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.32 -0.37 1.88e-12 Total cholesterol levels; LUSC cis rs57549656 0.799 rs72980731 chr19:2711234 G/A cg06609049 chr19:2785107 THOP1 0.49 6.21 0.32 1.62e-9 Schizophrenia; LUSC cis rs9653442 0.545 rs11900482 chr2:100758709 G/C cg22139774 chr2:100720529 AFF3 -0.43 -7.28 -0.37 2.38e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg13010199 chr12:38710504 ALG10B 0.7 11.58 0.54 2.64e-26 Heart rate; LUSC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.65 -0.34 1.23e-10 Height; LUSC cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.8 0.6 1.3600000000000001e-34 Chronic sinus infection; LUSC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.38 -5.92 -0.31 7.78e-9 Alzheimer's disease (late onset); LUSC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.82 0.35 4.17e-11 Platelet count; LUSC cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg22508957 chr16:3507546 NAT15 -0.43 -6.1 -0.32 2.92e-9 Body mass index (adult); LUSC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg08888203 chr3:10149979 C3orf24 0.45 6.83 0.35 4.08e-11 Alzheimer's disease; LUSC trans rs853679 0.517 rs12332979 chr6:28141548 T/G cg06606381 chr12:133084897 FBRSL1 -0.46 -6.15 -0.32 2.16e-9 Depression; LUSC cis rs1448094 0.565 rs73177163 chr12:86317533 G/T cg18827107 chr12:86230957 RASSF9 -0.43 -5.67 -0.3 3.01e-8 Major depressive disorder; LUSC cis rs3126085 0.935 rs11204947 chr1:152218257 G/T cg26876637 chr1:152193138 HRNR -0.46 -6.34 -0.33 7.49e-10 Atopic dermatitis; LUSC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg19717773 chr7:2847554 GNA12 -0.36 -6.2 -0.32 1.63e-9 Height; LUSC cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg06671706 chr8:8559999 CLDN23 0.48 6.44 0.33 4.23e-10 Obesity-related traits; LUSC cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg06627557 chr7:32535165 LSM5;AVL9 1.08 21.02 0.75 4.3e-63 Cognitive ability; LUSC cis rs2299587 0.560 rs11996792 chr8:17781012 C/G cg01800426 chr8:17659068 MTUS1 -0.49 -6.46 -0.33 3.74e-10 Economic and political preferences; LUSC cis rs7296418 0.599 rs2277343 chr12:123794450 A/T cg05973401 chr12:123451056 ABCB9 0.54 7.91 0.4 3.73e-14 Platelet count; LUSC cis rs300703 0.576 rs3791216 chr2:237142 C/A cg21211680 chr2:198530 NA 0.72 7.52 0.38 5.05e-13 Blood protein levels; LUSC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg11317459 chr13:21872234 NA 1.03 14.65 0.63 6.78e-38 White matter hyperintensity burden; LUSC cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg00504896 chr12:9437009 LOC642846 -0.48 -7.64 -0.39 2.28e-13 Breast size; LUSC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg12311346 chr5:56204834 C5orf35 -0.64 -9.47 -0.46 5.12e-19 Coronary artery disease; LUSC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.18 -0.32 1.82e-9 Total body bone mineral density; LUSC trans rs2243480 1.000 rs34815098 chr7:65292254 A/C cg10756647 chr7:56101905 PSPH 0.87 8.4 0.42 1.31e-15 Diabetic kidney disease; LUSC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg06481639 chr22:41940642 POLR3H 0.52 5.95 0.31 6.65e-9 Vitiligo; LUSC cis rs17029056 0.527 rs1806627 chr2:42157655 C/T cg25815440 chr2:42134162 NA -0.33 -6.84 -0.35 3.69e-11 Breast cancer; LUSC cis rs317689 0.819 rs317685 chr12:69715457 A/G cg11871910 chr12:69753446 YEATS4 -0.47 -6.29 -0.33 1.01e-9 Response to diuretic therapy; LUSC cis rs7917772 0.560 rs10786697 chr10:104378563 G/T cg22532475 chr10:104410764 TRIM8 -0.26 -6.05 -0.31 3.8e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg04455712 chr21:45112962 RRP1B 0.46 8.73 0.43 1.2e-16 Mean corpuscular volume; LUSC cis rs239198 0.577 rs34716527 chr6:101284416 T/C cg09795085 chr6:101329169 ASCC3 0.45 6.37 0.33 6.14e-10 Menarche (age at onset); LUSC cis rs12220238 1.000 rs10824105 chr10:75952881 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.8 0.35 4.73e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs13315871 1.000 rs28489489 chr3:58443755 C/A cg20936604 chr3:58311152 NA -0.72 -6.77 -0.35 5.83e-11 Cholesterol, total; LUSC cis rs10751667 0.961 rs6597971 chr11:928598 T/A ch.11.42038R chr11:967971 AP2A2 0.53 7.83 0.39 6.49e-14 Alzheimer's disease (late onset); LUSC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg11062466 chr8:58055876 NA 0.66 8.57 0.42 3.86e-16 Developmental language disorder (linguistic errors); LUSC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg14830002 chr1:247616686 OR2B11 0.49 7.05 0.36 1.05e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs62400317 0.859 rs72860105 chr6:45265201 A/T cg18551225 chr6:44695536 NA -0.42 -7.08 -0.36 8.7e-12 Total body bone mineral density; LUSC cis rs189798 0.807 rs330905 chr8:8993551 A/T cg06636001 chr8:8085503 FLJ10661 0.49 6.91 0.35 2.39e-11 Myopia (pathological); LUSC cis rs7258465 0.931 rs76195 chr19:18629830 A/G cg06462663 chr19:18546047 ISYNA1 0.42 7.26 0.37 2.65e-12 Breast cancer; LUSC cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.82 0.43 6.39e-17 Menopause (age at onset); LUSC cis rs8038465 0.623 rs6495073 chr15:73947534 A/T cg15420318 chr15:73925796 NPTN 0.6 10.15 0.49 2.93e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg26384229 chr12:38710491 ALG10B 0.88 14.7 0.63 4.61e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg21518248 chr2:162101506 NA 0.45 6.87 0.35 3.14e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs35883536 0.609 rs12747197 chr1:101036831 A/C cg06223162 chr1:101003688 GPR88 -0.48 -9.06 -0.44 1.13e-17 Monocyte count; LUSC cis rs7945705 0.818 rs10769948 chr11:8761782 C/T cg12365402 chr11:9010492 NRIP3 -0.41 -7.22 -0.37 3.45e-12 Hemoglobin concentration; LUSC cis rs4654899 0.865 rs6426674 chr1:21483906 C/T cg02927042 chr1:21476669 EIF4G3 -0.36 -5.69 -0.3 2.82e-8 Superior frontal gyrus grey matter volume; LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg11843238 chr5:131593191 PDLIM4 0.39 6.52 0.34 2.63e-10 Breast cancer; LUSC cis rs9287719 0.967 rs6712304 chr2:10754375 A/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs897984 0.542 rs4468641 chr16:31096876 A/C cg02466173 chr16:30829666 NA -0.51 -9.89 -0.48 2.09e-20 Dementia with Lewy bodies; LUSC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg12310025 chr6:25882481 NA 0.49 8.29 0.41 2.79e-15 Intelligence (multi-trait analysis); LUSC trans rs77372450 0.551 rs11739081 chr5:157087119 C/G cg10450108 chr5:140208893 PCDHA6;PCDHA2;PCDHA1;PCDHA5;PCDHA3;PCDHA4 -0.51 -6.08 -0.32 3.3e-9 Bipolar disorder (body mass index interaction); LUSC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg21724239 chr8:58056113 NA 0.86 9.61 0.47 1.83e-19 Developmental language disorder (linguistic errors); LUSC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.49 -6.17 -0.32 1.94e-9 Schizophrenia; LUSC cis rs5769707 0.681 rs9616329 chr22:50026314 G/A cg10356904 chr22:49881777 NA -0.28 -5.82 -0.3 1.35e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.44 -6.47 -0.33 3.54e-10 Schizophrenia; LUSC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.83 0.39 6.38e-14 Parkinson's disease; LUSC cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg14689365 chr7:158441557 NCAPG2 -0.46 -6.34 -0.33 7.64e-10 Height; LUSC cis rs55883249 1.000 rs76964971 chr2:9763904 C/A cg23886495 chr2:9695866 ADAM17 0.51 6.07 0.32 3.38e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17403046 chr12:113596797 DDX54;CCDC42B 0.49 6.32 0.33 8.15e-10 Bipolar disorder and schizophrenia; LUSC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg18225595 chr11:63971243 STIP1 -0.49 -8.14 -0.41 8.16e-15 Platelet count; LUSC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg18404041 chr3:52824283 ITIH1 0.44 7.82 0.39 6.94e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg24324837 chr19:49891574 CCDC155 -0.49 -6.29 -0.33 9.72e-10 Multiple sclerosis; LUSC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg15744005 chr10:104629667 AS3MT -0.28 -5.9 -0.31 8.73e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6701037 1.000 rs1057305 chr1:175126223 T/A cg17845761 chr1:175162550 KIAA0040 -0.33 -6.19 -0.32 1.74e-9 Alcohol dependence; LUSC cis rs3820928 0.874 rs6740108 chr2:227889559 G/T cg11843606 chr2:227700838 RHBDD1 0.51 7.42 0.38 1.01e-12 Pulmonary function; LUSC cis rs113835537 0.529 rs12099041 chr11:66232773 C/T cg24851651 chr11:66362959 CCS 0.54 8.27 0.41 3.33e-15 Airway imaging phenotypes; LUSC trans rs61931739 0.500 rs7979769 chr12:34509522 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.57 0.65 1.71e-41 Morning vs. evening chronotype; LUSC cis rs965469 1.000 rs6051763 chr20:3321616 T/G cg25506879 chr20:3388711 C20orf194 -0.51 -5.7 -0.3 2.57e-8 IFN-related cytopenia; LUSC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg12311346 chr5:56204834 C5orf35 -0.63 -9.66 -0.47 1.28e-19 Coronary artery disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg27629023 chr11:62648823 SLC3A2 -0.54 -6.34 -0.33 7.65e-10 Bipolar disorder and schizophrenia; LUSC cis rs2635047 1.000 rs2684841 chr18:44724262 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.71 0.34 8.47e-11 Educational attainment; LUSC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg21724239 chr8:58056113 NA 0.74 8.15 0.41 7.47e-15 Developmental language disorder (linguistic errors); LUSC cis rs8141529 1.000 rs132534 chr22:29299806 T/C cg02153584 chr22:29168773 CCDC117 -0.55 -7.55 -0.38 4.19e-13 Lymphocyte counts; LUSC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg18904891 chr8:8559673 CLDN23 -0.56 -8.03 -0.4 1.65e-14 Obesity-related traits; LUSC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.46 -0.65 4.94e-41 Gut microbiome composition (summer); LUSC cis rs7267979 0.966 rs2424715 chr20:25420077 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.86 19.97 0.74 5.81e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs59104589 0.617 rs3771561 chr2:242353704 A/G cg14842376 chr2:242211374 HDLBP -0.52 -6.15 -0.32 2.23e-9 Fibrinogen levels; LUSC cis rs6964587 0.869 rs34791781 chr7:91532720 C/T cg22709100 chr7:91322751 NA -0.4 -5.84 -0.3 1.21e-8 Breast cancer; LUSC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg23262073 chr20:60523788 NA -0.44 -6.51 -0.34 2.69e-10 Body mass index; LUSC cis rs1372520 0.684 rs184810 chr4:90697979 T/C cg01966878 chr4:90757139 SNCA 0.44 5.94 0.31 7e-9 Neuroticism; LUSC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg15445000 chr17:37608096 MED1 -0.39 -6.75 -0.35 6.68e-11 Glomerular filtration rate (creatinine); LUSC cis rs12310956 0.515 rs11052934 chr12:33970381 T/C cg06521331 chr12:34319734 NA -0.44 -7.29 -0.37 2.31e-12 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg00166722 chr3:10149974 C3orf24 0.69 9.23 0.45 3.28e-18 Alzheimer's disease; LUSC cis rs7106204 0.925 rs3924745 chr11:24223001 G/A ch.11.24196551F chr11:24239977 NA 1.13 14.59 0.62 1.21e-37 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7084921 0.552 rs1324693 chr10:101890617 A/G cg02250046 chr10:101825185 CPN1 -0.33 -6.08 -0.32 3.29e-9 Bone mineral density; LUSC cis rs34779708 0.966 rs2045917 chr10:35418526 G/A cg03585969 chr10:35415529 CREM 0.61 9.13 0.45 6.77e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7197653 0.748 rs11350 chr16:68335392 A/G cg09835421 chr16:68378352 PRMT7 -0.73 -8.02 -0.4 1.85e-14 Magnesium levels; LUSC cis rs1448094 0.706 rs10863149 chr12:86425498 A/T cg02569458 chr12:86230093 RASSF9 0.4 6.54 0.34 2.28e-10 Major depressive disorder; LUSC cis rs950776 0.518 rs62008174 chr15:78808947 C/T cg06917634 chr15:78832804 PSMA4 0.82 14.69 0.63 4.94e-38 Sudden cardiac arrest; LUSC cis rs6460942 1.000 rs17668923 chr7:12302873 A/T cg06484146 chr7:12443880 VWDE -0.55 -6.12 -0.32 2.63e-9 Coronary artery disease; LUSC cis rs7100689 0.646 rs1953972 chr10:82145666 A/G cg00277334 chr10:82204260 NA -0.51 -7.34 -0.37 1.64e-12 Post bronchodilator FEV1; LUSC cis rs4704187 0.617 rs12656177 chr5:74354422 G/A cg03227963 chr5:74354835 NA 0.32 6.94 0.36 2.03e-11 Response to amphetamines; LUSC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.49 5.86 0.31 1.08e-8 Renal function-related traits (BUN); LUSC cis rs9393692 0.645 rs4145910 chr6:26313305 T/C cg13736514 chr6:26305472 NA -0.54 -10.4 -0.49 3.89e-22 Educational attainment; LUSC cis rs62238980 0.614 rs4821018 chr22:32403318 A/G cg01616215 chr22:32340373 YWHAH;C22orf24 -0.81 -5.9 -0.31 8.82e-9 Childhood ear infection; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14848284 chr2:73143293 EMX1 -0.5 -5.95 -0.31 6.72e-9 Bipolar disorder and schizophrenia; LUSC cis rs854765 0.624 rs9902941 chr17:17733760 C/T cg04398451 chr17:18023971 MYO15A 0.39 5.96 0.31 6.28e-9 Total body bone mineral density; LUSC cis rs2404602 0.692 rs12911174 chr15:77149943 G/A cg23625390 chr15:77176239 SCAPER 0.48 7.28 0.37 2.37e-12 Blood metabolite levels; LUSC cis rs9326248 0.581 rs7120963 chr11:116830261 C/T cg11861562 chr11:117069780 TAGLN -0.33 -6.3 -0.33 9.22e-10 Blood protein levels; LUSC cis rs936229 0.954 rs936230 chr15:75145098 C/T cg10253484 chr15:75165896 SCAMP2 0.57 7.65 0.39 2.2e-13 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs2820315 1.000 rs2820310 chr1:201838107 G/A cg10061532 chr1:201886748 LMOD1 0.26 5.84 0.3 1.24e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs2404602 0.735 rs11072598 chr15:76764788 T/C cg23625390 chr15:77176239 SCAPER -0.62 -9.44 -0.46 6.65e-19 Blood metabolite levels; LUSC trans rs2262909 0.924 rs4290587 chr19:22164646 A/G cg17074339 chr11:11642133 GALNTL4 -0.41 -6.17 -0.32 1.96e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg18758796 chr5:131593413 PDLIM4 0.41 6.69 0.34 9.39e-11 Breast cancer; LUSC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg23711669 chr6:146136114 FBXO30 -0.89 -16.7 -0.67 6e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs977987 0.736 rs4888392 chr16:75412262 T/C cg03315344 chr16:75512273 CHST6 0.49 9.32 0.45 1.6e-18 Dupuytren's disease; LUSC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg10523679 chr1:76189770 ACADM -0.93 -19.78 -0.73 3.55e-58 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs9663711 1 rs9663711 chr10:104547628 C/A cg04362960 chr10:104952993 NT5C2 0.47 6.48 0.33 3.25e-10 Carotid plaque burden; LUSC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg26677194 chr12:130822605 PIWIL1 0.59 8.8 0.43 7.28e-17 Menopause (age at onset); LUSC cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg23788917 chr6:8435910 SLC35B3 0.51 7.49 0.38 6.32e-13 Motion sickness; LUSC cis rs9788682 0.668 rs2036529 chr15:78726272 A/T cg18825076 chr15:78729989 IREB2 -0.43 -5.85 -0.31 1.15e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs10761482 0.861 rs2061488 chr10:62103166 A/G cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.72 -12.35 -0.56 3.96e-29 Prudent dietary pattern; LUSC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.86e-9 Major depressive disorder; LUSC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg25767906 chr1:53392781 SCP2 0.46 8.31 0.41 2.37e-15 Monocyte count; LUSC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg09034736 chr1:150693464 HORMAD1 0.46 6.34 0.33 7.64e-10 Melanoma; LUSC cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg15997130 chr1:24165203 NA 0.52 8.61 0.43 2.98e-16 Immature fraction of reticulocytes; LUSC cis rs2439831 0.681 rs511673 chr15:43618863 T/C cg02155558 chr15:43621948 ADAL;LCMT2 1.1 15.06 0.64 1.72e-39 Lung cancer in ever smokers; LUSC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg06212747 chr3:49208901 KLHDC8B 0.53 7.03 0.36 1.17e-11 Parkinson's disease; LUSC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg24585782 chr17:78113791 EIF4A3 -0.53 -7.88 -0.4 4.79e-14 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs116095464 0.558 rs28636067 chr5:199415 G/A cg22857025 chr5:266934 NA -1.2 -13.69 -0.6 3.65e-34 Breast cancer; LUSC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg26441486 chr22:50317300 CRELD2 -0.41 -6.12 -0.32 2.69e-9 Schizophrenia; LUSC cis rs2859741 0.967 rs592520 chr1:37513503 G/C cg09363841 chr1:37513479 NA -0.39 -7.77 -0.39 1.01e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs9807989 0.839 rs9808453 chr2:102971306 C/A cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg13732083 chr21:47605072 C21orf56 -0.45 -6.7 -0.34 8.72e-11 Testicular germ cell tumor; LUSC cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg08213375 chr14:104286397 PPP1R13B 0.53 10.54 0.5 1.28e-22 Schizophrenia; LUSC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg26380479 chr7:97908229 NA -0.27 -5.97 -0.31 6.08e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02934834 chr6:116575324 TSPYL4 0.45 6.15 0.32 2.27e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7106204 0.590 rs7115417 chr11:24247696 A/G ch.11.24196551F chr11:24239977 NA 1.03 12.33 0.56 4.87e-29 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1832871 0.521 rs62437411 chr6:158823211 G/A cg07165851 chr6:158734300 TULP4 0.38 6.1 0.32 2.9e-9 Height; LUSC trans rs7824557 0.564 rs2736294 chr8:11234626 T/C cg15556689 chr8:8085844 FLJ10661 -0.5 -7.53 -0.38 4.7e-13 Retinal vascular caliber; LUSC trans rs61931739 0.534 rs11053131 chr12:34282109 A/G cg13010199 chr12:38710504 ALG10B 0.45 7.01 0.36 1.31e-11 Morning vs. evening chronotype; LUSC cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg03146154 chr1:46216737 IPP -0.51 -7.43 -0.38 9.2e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg20295408 chr7:1910781 MAD1L1 -0.5 -7.23 -0.37 3.3e-12 Bipolar disorder and schizophrenia; LUSC cis rs72781680 0.898 rs6712175 chr2:24023431 T/G cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC trans rs12210905 0.688 rs12213533 chr6:27346021 C/T cg02699829 chr19:13216355 TRMT1 -0.56 -6.33 -0.33 7.7e-10 Hip circumference adjusted for BMI; LUSC cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg19875535 chr5:140030758 IK 0.54 8.98 0.44 2.03e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg05973401 chr12:123451056 ABCB9 -0.49 -6.05 -0.31 3.86e-9 Neutrophil percentage of white cells; LUSC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg11764359 chr7:65958608 NA -0.8 -13.13 -0.58 4.83e-32 Aortic root size; LUSC cis rs4343996 0.902 rs12540305 chr7:3376072 A/T cg21248987 chr7:3385318 SDK1 -0.4 -6.92 -0.35 2.29e-11 Motion sickness; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10493356 chr22:31608270 LIMK2 -0.43 -6.44 -0.33 4.05e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg16514724 chr10:97453245 TCTN3 -0.43 -6.32 -0.33 8.39e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10207060 0.522 rs62183177 chr2:240712665 A/G cg07506560 chr2:240697449 NA 0.41 6.49 0.33 3.19e-10 Obesity-related traits; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.87 0.54 2.36e-27 Prudent dietary pattern; LUSC cis rs929354 0.742 rs7801905 chr7:156940111 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.01 0.58 1.35e-31 Body mass index; LUSC cis rs921968 0.541 rs532425 chr2:219434194 A/G cg02176678 chr2:219576539 TTLL4 0.75 14.64 0.63 7.48e-38 Mean corpuscular hemoglobin concentration; LUSC trans rs12902680 0.641 rs7183417 chr15:46586088 C/T cg04321580 chr8:143696133 ARC -0.4 -6.04 -0.31 4.18e-9 Neuroticism; LUSC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg17633681 chr16:88106987 BANP 0.52 9.83 0.47 3.32e-20 Menopause (age at onset); LUSC cis rs2839186 0.967 rs4819222 chr21:47707778 G/A cg11766577 chr21:47581405 C21orf56 -0.41 -5.99 -0.31 5.37e-9 Testicular germ cell tumor; LUSC cis rs427394 0.802 rs200841 chr5:6737134 A/G cg10857441 chr5:6722123 POLS -0.46 -8.95 -0.44 2.58e-17 Menopause (age at onset); LUSC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg19346786 chr7:2764209 NA -0.45 -7.54 -0.38 4.6e-13 Height; LUSC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg00509249 chr6:109615579 CCDC162 -0.33 -6.05 -0.31 3.86e-9 Reticulocyte fraction of red cells; LUSC cis rs7267979 1.000 rs2500405 chr20:25360826 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.57 -0.69 2.11e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg23711669 chr6:146136114 FBXO30 0.77 13.91 0.61 5.36e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs1044826 0.692 rs188420 chr3:139233865 G/A cg15131784 chr3:139108705 COPB2 -0.39 -6.34 -0.33 7.63e-10 Obesity-related traits; LUSC cis rs1018836 0.923 rs7826178 chr8:91649592 C/A cg16814680 chr8:91681699 NA -0.8 -13.66 -0.6 4.74e-34 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg23711669 chr6:146136114 FBXO30 0.93 18.15 0.7 1e-51 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs11513287 chr12:34584351 G/A cg13010199 chr12:38710504 ALG10B 0.66 10.24 0.49 1.42e-21 Morning vs. evening chronotype; LUSC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg13560548 chr3:10150139 C3orf24 0.51 7.35 0.37 1.56e-12 Alzheimer's disease; LUSC cis rs28647808 0.786 rs4962137 chr9:136256826 G/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC trans rs7944735 0.517 rs11039538 chr11:48154990 A/T cg03929089 chr4:120376271 NA 0.71 6.42 0.33 4.71e-10 Intraocular pressure; LUSC cis rs9640161 0.830 rs17173703 chr7:150068620 C/T cg21361702 chr7:150065534 REPIN1 0.57 8.0 0.4 2.14e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg14552801 chr7:65878734 NA 0.38 6.03 0.31 4.28e-9 Aortic root size; LUSC cis rs4911259 0.513 rs4287835 chr20:31457337 T/C cg13636640 chr20:31349939 DNMT3B -0.8 -15.48 -0.65 4.16e-41 Inflammatory bowel disease; LUSC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg26119090 chr2:26468346 HADHA;HADHB 0.81 9.81 0.47 3.85e-20 Gut microbiome composition (summer); LUSC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg13531842 chr10:38383804 ZNF37A 0.47 7.39 0.38 1.16e-12 Extrinsic epigenetic age acceleration; LUSC cis rs9322193 0.567 rs7747457 chr6:150213502 T/A cg04369109 chr6:150039330 LATS1 -0.41 -5.77 -0.3 1.84e-8 Lung cancer; LUSC trans rs6427356 1.000 rs1176555 chr1:157136541 C/G cg04591034 chr5:178017937 COL23A1 0.39 6.48 0.33 3.27e-10 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg04539111 chr16:67997858 SLC12A4 -0.46 -6.25 -0.32 1.23e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2976388 1.000 rs2920292 chr8:143765699 A/G cg17252645 chr8:143867129 LY6D -0.37 -6.44 -0.33 4.28e-10 Urinary tract infection frequency; LUSC cis rs7640424 0.716 rs35703078 chr3:107859558 A/G cg09227934 chr3:107805635 CD47 -0.4 -6.27 -0.32 1.09e-9 Body mass index; LUSC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg09060608 chr5:178986726 RUFY1 0.62 10.87 0.51 9.18e-24 Lung cancer; LUSC trans rs2243480 1.000 rs1618893 chr7:66096119 C/T cg10756647 chr7:56101905 PSPH 0.75 7.6 0.38 3.06e-13 Diabetic kidney disease; LUSC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg16647868 chr5:131706066 SLC22A5 0.4 6.08 0.32 3.24e-9 Acylcarnitine levels; LUSC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg04352962 chr1:209979756 IRF6 0.52 5.78 0.3 1.74e-8 Coronary artery disease; LUSC cis rs559928 1.000 rs641168 chr11:64146289 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.61 -6.68 -0.34 1.02e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs6089829 0.962 rs6011544 chr20:61658782 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 8.89 0.44 3.82e-17 Prostate cancer (SNP x SNP interaction); LUSC cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg04733989 chr22:42467013 NAGA -0.41 -6.64 -0.34 1.24e-10 Cognitive function; LUSC cis rs2580764 0.566 rs2972072 chr2:55295370 G/T cg20993754 chr2:55226987 RTN4 -0.37 -6.28 -0.32 1.07e-9 Mean platelet volume; LUSC cis rs8060686 0.623 rs12599178 chr16:68128104 A/G cg26727032 chr16:67993705 SLC12A4 -0.42 -6.71 -0.34 8.2e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22590775 chr19:49891494 CCDC155 0.59 8.33 0.41 2.16e-15 Multiple sclerosis; LUSC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg24642439 chr20:33292090 TP53INP2 0.54 8.13 0.41 8.78e-15 Height; LUSC cis rs2816062 0.775 rs2816048 chr1:18893763 T/C cg18795169 chr1:18902165 NA -1.0 -24.12 -0.8 3.83e-75 Urate levels in lean individuals; LUSC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg02038168 chr22:39784481 NA -0.43 -6.39 -0.33 5.45e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg20243544 chr17:37824526 PNMT 0.39 5.85 0.3 1.19e-8 Self-reported allergy; LUSC cis rs2692947 0.759 rs2949885 chr2:96662415 A/G cg23100626 chr2:96804247 ASTL 0.26 6.18 0.32 1.86e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs4776059 0.761 rs12594964 chr15:52900208 G/A cg25063058 chr15:52860530 ARPP19 -0.47 -5.86 -0.31 1.13e-8 Schizophrenia; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg07677032 chr17:61819896 STRADA 0.53 9.0 0.44 1.69e-17 Prudent dietary pattern; LUSC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.17 15.04 0.64 2.12e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC trans rs1814175 0.904 rs1846289 chr11:49620253 G/A cg03929089 chr4:120376271 NA -0.98 -17.49 -0.69 4.27e-49 Height; LUSC trans rs2832077 1.000 rs12329875 chr21:30137796 C/T cg14791747 chr16:20752902 THUMPD1 0.73 9.63 0.47 1.54e-19 Cognitive test performance; LUSC cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg04267008 chr7:1944627 MAD1L1 -0.46 -6.97 -0.36 1.74e-11 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg25767906 chr1:53392781 SCP2 -0.52 -9.58 -0.46 2.27e-19 Monocyte count; LUSC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg06600287 chr1:53387719 ECHDC2 0.28 5.66 0.3 3.29e-8 Monocyte count; LUSC cis rs7647973 0.925 rs11130183 chr3:49228946 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.46 6.85 0.35 3.64e-11 Menarche (age at onset); LUSC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -6.98 -0.36 1.62e-11 Lung cancer; LUSC cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg08999081 chr20:33150536 PIGU -0.51 -10.02 -0.48 7.54e-21 Glomerular filtration rate (creatinine); LUSC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.5 0.62 2.79e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg07677032 chr17:61819896 STRADA 0.53 8.85 0.44 5.06e-17 Prudent dietary pattern; LUSC cis rs861020 0.630 rs628445 chr1:210004953 C/T cg05527609 chr1:210001259 C1orf107 0.67 9.63 0.47 1.5700000000000001e-19 Orofacial clefts; LUSC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg06740227 chr12:86229804 RASSF9 0.4 6.19 0.32 1.77e-9 Major depressive disorder; LUSC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg07507251 chr3:52567010 NT5DC2 0.37 7.5 0.38 5.96e-13 Electroencephalogram traits; LUSC cis rs8044995 0.563 rs56899435 chr16:68395675 G/A cg05110241 chr16:68378359 PRMT7 -0.78 -8.77 -0.43 9.38e-17 Schizophrenia; LUSC cis rs951366 0.531 rs12047038 chr1:205718468 A/G cg14893161 chr1:205819251 PM20D1 -0.48 -6.46 -0.33 3.63e-10 Menarche (age at onset); LUSC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg12927641 chr6:109611667 NA -0.35 -6.0 -0.31 5.18e-9 Reticulocyte fraction of red cells; LUSC cis rs35883536 0.647 rs10875313 chr1:101043057 T/C cg06223162 chr1:101003688 GPR88 -0.48 -9.13 -0.45 6.71e-18 Monocyte count; LUSC cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg15839431 chr19:19639596 YJEFN3 -0.63 -7.15 -0.36 5.48e-12 Bipolar disorder; LUSC trans rs9467711 0.584 rs34244947 chr6:26761745 T/C cg06606381 chr12:133084897 FBRSL1 -0.88 -7.56 -0.38 3.87e-13 Autism spectrum disorder or schizophrenia; LUSC cis rs6732160 0.691 rs2007191 chr2:73421463 T/G cg24220031 chr2:73402428 NA -0.23 -5.76 -0.3 1.9e-8 Intelligence (multi-trait analysis); LUSC cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg25173405 chr17:45401733 C17orf57 0.38 6.13 0.32 2.49e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs17401966 0.931 rs17034821 chr1:10414645 A/G cg19773385 chr1:10388646 KIF1B -0.58 -9.93 -0.48 1.59e-20 Hepatocellular carcinoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23227555 chr2:3523215 ADI1 -0.4 -6.38 -0.33 5.94e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7191700 0.644 rs12149160 chr16:11439303 G/T cg00044050 chr16:11439710 C16orf75 -0.78 -15.02 -0.63 2.54e-39 Multiple sclerosis; LUSC cis rs6942756 0.876 rs2303303 chr7:129019736 G/A cg02491457 chr7:128862824 NA -0.4 -5.84 -0.3 1.23e-8 White matter hyperintensity burden; LUSC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg11494091 chr17:61959527 GH2 0.63 13.39 0.59 4.87e-33 Prudent dietary pattern; LUSC cis rs17767294 0.612 rs9461425 chr6:27919688 G/A cg08851530 chr6:28072375 NA 0.86 6.66 0.34 1.15e-10 Parkinson's disease; LUSC cis rs3820928 0.874 rs4234062 chr2:227819050 C/A cg11843606 chr2:227700838 RHBDD1 -0.52 -7.63 -0.39 2.4e-13 Pulmonary function; LUSC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.71 -0.6 3.02e-34 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.681 rs2271342 chr8:8643938 C/T cg18904891 chr8:8559673 CLDN23 0.42 6.49 0.33 3.03e-10 Mood instability; LUSC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg18876405 chr7:65276391 NA 0.59 9.6 0.47 1.9e-19 Aortic root size; LUSC cis rs9715521 0.557 rs13146381 chr4:59853842 T/C cg11281224 chr4:60001000 NA -0.48 -6.85 -0.35 3.62e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs10911232 0.507 rs6664995 chr1:183017345 T/C ch.1.3577855R chr1:183094577 LAMC1 0.71 10.91 0.51 6.56e-24 Hypertriglyceridemia; LUSC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg14668632 chr7:2872130 GNA12 -0.43 -6.05 -0.31 3.84e-9 Height; LUSC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg06238570 chr21:40685208 BRWD1 0.53 8.3 0.41 2.54e-15 Cognitive function; LUSC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg20476274 chr7:133979776 SLC35B4 0.87 16.7 0.67 6.08e-46 Mean platelet volume; LUSC trans rs2797160 0.651 rs6569437 chr6:126034540 T/G cg05039488 chr6:79577232 IRAK1BP1 0.62 9.74 0.47 6.83e-20 Endometrial cancer; LUSC trans rs11098499 0.863 rs9997631 chr4:120469995 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.79 0.35 5.24e-11 Corneal astigmatism; LUSC cis rs10992471 1.000 rs10992471 chr9:95559505 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.33 6.06 0.31 3.72e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg03709012 chr19:19516395 GATAD2A 0.77 11.79 0.54 4.52e-27 Tonsillectomy; LUSC cis rs7178572 0.889 rs907388 chr15:77828668 G/A cg22256960 chr15:77711686 NA -0.52 -8.63 -0.43 2.45e-16 Type 2 diabetes; LUSC cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 8.38 0.42 1.45e-15 Colorectal cancer; LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs2267681 0.508 rs10277705 chr7:139519293 C/G cg14116596 chr7:139528673 TBXAS1 0.38 6.63 0.34 1.34e-10 Cervical cancer; LUSC cis rs11587682 0.760 rs1043293 chr1:150448766 G/C cg11822372 chr1:151115635 SEMA6C -0.43 -5.71 -0.3 2.48e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2404602 0.647 rs8025991 chr15:77155268 C/T cg23625390 chr15:77176239 SCAPER -0.66 -10.18 -0.49 2.17e-21 Blood metabolite levels; LUSC cis rs7598759 1.000 rs7598759 chr2:232321956 C/T cg19187155 chr2:232395269 NMUR1 0.5 7.63 0.39 2.56e-13 Noise-induced hearing loss; LUSC cis rs7267979 0.966 rs6037083 chr20:25290543 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.58 -0.75 2.39e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs54211 1.000 rs137610 chr22:39697793 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.6 5.78 0.3 1.72e-8 Sudden cardiac arrest; LUSC cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg17143192 chr8:8559678 CLDN23 0.64 9.02 0.44 1.47e-17 Obesity-related traits; LUSC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg19678392 chr7:94953810 PON1 -0.38 -6.21 -0.32 1.61e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16333535 chr22:24093440 ZNF70 0.44 6.31 0.33 8.82e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9287719 0.967 rs10929682 chr2:10732189 C/A cg03983476 chr2:10830698 NOL10 -0.37 -5.67 -0.3 3.09e-8 Prostate cancer; LUSC cis rs5758511 0.731 rs5751186 chr22:42349710 G/A cg00645731 chr22:42541494 CYP2D7P1 -0.43 -7.13 -0.36 6.18e-12 Birth weight; LUSC cis rs7584330 0.737 rs1497128 chr2:238369211 A/G cg16989719 chr2:238392110 NA -0.37 -6.34 -0.33 7.24e-10 Prostate cancer; LUSC cis rs9467773 0.572 rs13213953 chr6:26594534 T/A cg09904177 chr6:26538194 HMGN4 0.66 11.11 0.52 1.27e-24 Intelligence (multi-trait analysis); LUSC cis rs9469578 0.579 rs73743401 chr6:33716945 G/T cg18708504 chr6:33715942 IP6K3 0.64 6.16 0.32 2.04e-9 Phosphorus levels; LUSC cis rs9300255 0.739 rs1980252 chr12:123745178 C/G cg00376283 chr12:123451042 ABCB9 0.66 8.34 0.42 2e-15 Neutrophil percentage of white cells; LUSC cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg12564285 chr5:131593104 PDLIM4 0.37 6.9 0.35 2.57e-11 Blood metabolite levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21692735 chr1:1691997 NADK 0.46 6.5 0.34 3e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs977987 0.806 rs8057203 chr16:75404974 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.85 -0.35 3.47e-11 Dupuytren's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15705266 chr17:33914268 AP2B1 0.43 6.06 0.31 3.7e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1506636 1.000 rs2259457 chr7:123424350 A/G cg03229431 chr7:123269106 ASB15 0.65 10.68 0.5 4.29e-23 Plateletcrit;Platelet count; LUSC cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg13072238 chr3:49761600 GMPPB -0.65 -7.68 -0.39 1.74e-13 Menarche (age at onset); LUSC trans rs7313075 0.850 rs35512374 chr12:102653564 T/C cg03720887 chr8:101963845 YWHAZ 0.67 6.18 0.32 1.82e-9 Height; LUSC cis rs3736594 0.959 rs10201247 chr2:27974971 A/G cg27432699 chr2:27873401 GPN1 -0.64 -9.13 -0.45 6.53e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs4891159 1.000 rs4891159 chr18:74101941 A/G cg24786174 chr18:74118243 ZNF516 0.69 12.19 0.55 1.59e-28 Longevity; LUSC trans rs9291683 0.588 rs2240721 chr4:10020564 G/A cg26043149 chr18:55253948 FECH 0.5 7.5 0.38 5.88e-13 Bone mineral density; LUSC cis rs3862435 1.000 rs3862435 chr15:91082532 A/G cg22089800 chr15:90895588 ZNF774 -0.61 -5.8 -0.3 1.55e-8 Response to exercise (triglyceride level interaction); LUSC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg06634786 chr22:41940651 POLR3H -0.55 -6.4 -0.33 5.2400000000000005e-10 Vitiligo; LUSC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg12463550 chr7:65579703 CRCP 0.62 5.67 0.3 3.04e-8 Diabetic kidney disease; LUSC cis rs8038465 0.638 rs8036954 chr15:73974282 T/C cg15420318 chr15:73925796 NPTN 0.59 10.04 0.48 6.91e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg18827107 chr12:86230957 RASSF9 -0.47 -7.06 -0.36 9.99e-12 Major depressive disorder; LUSC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.92 14.08 0.61 1.17e-35 Platelet count; LUSC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg09517075 chr8:22133004 PIWIL2 0.41 8.11 0.41 9.94e-15 Hypertriglyceridemia; LUSC cis rs7091068 0.536 rs503758 chr10:95406935 C/A cg20715218 chr10:95462985 C10orf4 -0.64 -8.34 -0.42 1.91e-15 Urinary tract infection frequency; LUSC trans rs17266958 1.000 rs17083743 chr9:83291465 A/G cg01905489 chr1:26616534 UBXN11 -0.59 -6.46 -0.33 3.79e-10 Preschool internalizing problems; LUSC cis rs7759001 0.857 rs6936356 chr6:27358853 A/C cg18711553 chr6:27366782 ZNF391 0.39 5.72 0.3 2.32e-8 Glomerular filtration rate (creatinine); LUSC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg26338869 chr17:61819248 STRADA 0.41 5.77 0.3 1.84e-8 Prudent dietary pattern; LUSC cis rs5769765 1.000 rs910800 chr22:50278642 C/T cg08270630 chr22:50330655 NA 0.41 6.05 0.31 3.98e-9 Schizophrenia; LUSC cis rs2798269 0.966 rs2798271 chr13:22136765 C/T cg18095732 chr13:22033692 ZDHHC20 -0.39 -6.04 -0.31 4.15e-9 PR segment; LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg08888203 chr3:10149979 C3orf24 -0.62 -8.07 -0.4 1.3e-14 Alzheimer's disease; LUSC cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.63 9.99 0.48 9.69e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg26408565 chr15:76604113 ETFA -0.49 -7.84 -0.39 6.1e-14 Blood metabolite levels; LUSC trans rs12310956 0.510 rs1825903 chr12:33870437 G/C cg13010199 chr12:38710504 ALG10B 0.45 6.92 0.35 2.27e-11 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.54 0.5 1.24e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg18681998 chr4:17616180 MED28 -0.83 -14.73 -0.63 3.54e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg21782813 chr7:2030301 MAD1L1 0.53 9.11 0.45 7.53e-18 Schizophrenia; LUSC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.49 0.33 3.09e-10 Lung cancer; LUSC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.73 0.3 2.21e-8 Major depressive disorder; LUSC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg24531977 chr5:56204891 C5orf35 0.86 13.9 0.61 5.79e-35 Initial pursuit acceleration; LUSC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg24881330 chr22:46731750 TRMU -0.89 -10.03 -0.48 6.95e-21 LDL cholesterol;Cholesterol, total; LUSC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg03806693 chr22:41940476 POLR3H -0.93 -13.27 -0.59 1.43e-32 Vitiligo; LUSC cis rs76878669 0.561 rs12794121 chr11:66126169 G/T cg24851651 chr11:66362959 CCS -0.36 -5.73 -0.3 2.25e-8 Educational attainment (years of education); LUSC cis rs10256972 0.630 rs10282584 chr7:1081442 C/T cg16145915 chr7:1198662 ZFAND2A -0.4 -7.4 -0.38 1.15e-12 Longevity;Endometriosis; LUSC cis rs7605827 0.930 rs11898971 chr2:15613678 C/T cg19274914 chr2:15703543 NA -0.47 -9.22 -0.45 3.49e-18 Educational attainment (years of education); LUSC trans rs2262909 1.000 rs765527 chr19:22129555 A/G cg05197062 chr11:11642011 GALNTL4 0.5 6.85 0.35 3.6e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg08975724 chr8:8085496 FLJ10661 0.52 7.97 0.4 2.46e-14 Mood instability; LUSC cis rs17227506 0.529 rs13258748 chr8:13470909 A/T cg03566418 chr8:13424080 C8orf48 -0.38 -5.72 -0.3 2.42e-8 Nonsyndromic cleft lip with cleft palate; LUSC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg05347473 chr6:146136440 FBXO30 0.53 8.86 0.44 4.86e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg13010199 chr12:38710504 ALG10B 0.67 10.36 0.49 5.56e-22 Drug-induced liver injury (flucloxacillin); LUSC cis rs950169 0.840 rs2896002 chr15:84945121 A/G cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg08280861 chr8:58055591 NA 0.53 5.81 0.3 1.5e-8 Developmental language disorder (linguistic errors); LUSC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg12560992 chr17:57184187 TRIM37 0.84 15.44 0.65 5.6e-41 Intelligence (multi-trait analysis); LUSC cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg05985134 chr18:33552581 C18orf21 0.5 6.92 0.35 2.27e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg11060661 chr22:24314208 DDT;DDTL 0.5 8.18 0.41 5.81e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg14601938 chr1:150122016 PLEKHO1 0.39 6.17 0.32 1.99e-9 Asthma; LUSC cis rs10208940 0.920 rs35005506 chr2:68814238 A/T cg12452813 chr2:68675892 NA 0.59 6.08 0.32 3.21e-9 Urate levels in lean individuals; LUSC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg09323728 chr8:95962352 TP53INP1 -0.3 -5.71 -0.3 2.44e-8 Type 2 diabetes; LUSC cis rs10979 1.000 rs12738 chr6:143890049 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -11.94 -0.55 1.31e-27 Hypospadias; LUSC cis rs1371867 0.846 rs1788203 chr8:101303721 T/C cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.54e-15 Atrioventricular conduction; LUSC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg11812906 chr14:75593930 NEK9 0.67 11.56 0.53 3.11e-26 Height; LUSC trans rs61931739 0.853 rs7137146 chr12:34102394 G/A cg26384229 chr12:38710491 ALG10B -0.59 -9.51 -0.46 3.84e-19 Morning vs. evening chronotype; LUSC cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg06784218 chr1:46089804 CCDC17 0.57 11.33 0.53 2.06e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg26354017 chr1:205819088 PM20D1 0.52 8.56 0.42 4.25e-16 Menarche (age at onset); LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.05 0.4 1.51e-14 Prudent dietary pattern; LUSC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg17178900 chr1:205818956 PM20D1 -0.48 -7.24 -0.37 3.02e-12 Menarche (age at onset); LUSC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg05082376 chr22:42548792 NA -0.45 -7.14 -0.36 5.74e-12 Schizophrenia; LUSC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg20891283 chr12:69753455 YEATS4 0.93 17.88 0.7 1.24e-50 Cerebrospinal fluid biomarker levels; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg06873352 chr17:61820015 STRADA 0.71 12.72 0.57 1.68e-30 Prudent dietary pattern; LUSC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg11764359 chr7:65958608 NA 0.68 11.06 0.52 2e-24 Aortic root size; LUSC cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.34 -5.66 -0.3 3.24e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs8085804 0.611 rs11082292 chr18:40278773 A/G cg04486886 chr5:56784195 NA -0.31 -5.99 -0.31 5.5e-9 Cognitive performance; LUSC cis rs11122272 0.735 rs2491410 chr1:231532287 C/T cg06096015 chr1:231504339 EGLN1 0.56 9.96 0.48 1.25e-20 Hemoglobin concentration; LUSC cis rs6938 0.618 rs62029167 chr15:75228350 G/A cg09165964 chr15:75287851 SCAMP5 0.52 7.63 0.39 2.49e-13 Breast cancer; LUSC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg02423579 chr7:2872169 GNA12 -0.46 -6.4 -0.33 5.2400000000000005e-10 Height; LUSC cis rs11098499 0.863 rs7657849 chr4:120455494 T/C cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.18 -0.32 1.84e-9 Alzheimer's disease (late onset); LUSC cis rs7100689 0.646 rs1340380 chr10:82115619 T/C cg01528321 chr10:82214614 TSPAN14 0.88 13.27 0.59 1.49e-32 Post bronchodilator FEV1; LUSC cis rs11051970 0.636 rs2733704 chr12:32567858 C/T cg24626660 chr12:32551988 NA 0.3 5.65 0.3 3.46e-8 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs13108904 0.870 rs3775092 chr4:1240962 C/G cg05025164 chr4:1340916 KIAA1530 0.4 5.93 0.31 7.51e-9 Obesity-related traits; LUSC trans rs372883 0.648 rs11088117 chr21:30737816 G/C cg14791747 chr16:20752902 THUMPD1 -0.45 -6.59 -0.34 1.74e-10 Pancreatic cancer; LUSC trans rs1973993 0.745 rs986427 chr1:96932736 A/G cg10631902 chr5:14652156 NA -0.5 -7.52 -0.38 5.08e-13 Weight; LUSC cis rs6964587 0.692 rs4727268 chr7:91840724 T/C cg17063962 chr7:91808500 NA 0.61 10.19 0.49 2e-21 Breast cancer; LUSC cis rs6076065 0.722 rs6048760 chr20:23345844 G/T cg11657817 chr20:23433608 CST11 -0.54 -10.83 -0.51 1.24e-23 Facial morphology (factor 15, philtrum width); LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg08470875 chr2:26401718 FAM59B -0.72 -9.82 -0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs1506636 1.000 rs2429616 chr7:123406034 C/T cg03229431 chr7:123269106 ASB15 0.65 10.7 0.51 3.69e-23 Plateletcrit;Platelet count; LUSC cis rs968567 0.559 rs174544 chr11:61567753 C/A cg19610905 chr11:61596333 FADS2 -0.54 -7.91 -0.4 3.92e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; LUSC cis rs1904096 0.513 rs2632405 chr4:95152215 T/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.41 -0.42 1.2e-15 Type 2 diabetes; LUSC cis rs2289583 0.517 rs2004278 chr15:75264363 C/T cg14664628 chr15:75095509 CSK 0.46 6.32 0.33 8.14e-10 Systemic lupus erythematosus; LUSC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg01073479 chr16:3509474 NAT15 -0.42 -5.66 -0.3 3.21e-8 Tuberculosis; LUSC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg05043794 chr9:111880884 C9orf5 -0.4 -8.75 -0.43 1.09e-16 Menarche (age at onset); LUSC trans rs61931739 0.500 rs7308338 chr12:34553181 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.38 0.59 5.58e-33 Morning vs. evening chronotype; LUSC cis rs6714710 0.603 rs34502870 chr2:98405929 A/G cg26665480 chr2:98280029 ACTR1B 0.58 8.58 0.42 3.69e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg05872129 chr22:39784769 NA -0.57 -10.51 -0.5 1.6e-22 Intelligence (multi-trait analysis); LUSC cis rs6964587 0.967 rs10248102 chr7:91699779 G/A cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs11645898 0.625 rs8047930 chr16:72106024 C/T cg14768367 chr16:72042858 DHODH -0.51 -6.04 -0.31 4.14e-9 Blood protein levels; LUSC cis rs765787 0.530 rs12592055 chr15:45514477 C/T cg25801113 chr15:45476975 SHF -0.34 -6.7 -0.34 8.82e-11 Uric acid levels; LUSC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg22549504 chr19:17448937 GTPBP3 0.54 6.74 0.35 6.84e-11 Systemic lupus erythematosus; LUSC cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg12011299 chr4:100065546 ADH4 -0.7 -10.98 -0.51 3.78e-24 Smoking initiation; LUSC trans rs10851478 0.872 rs12591317 chr15:49945675 A/G cg23074453 chr15:44487924 FRMD5 -0.33 -6.12 -0.32 2.61e-9 Oral cavity cancer; LUSC cis rs1215050 0.740 rs783916 chr4:99026264 A/C cg05340658 chr4:99064831 C4orf37 -0.45 -7.28 -0.37 2.35e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs41271473 0.948 rs72750016 chr1:228816786 G/C cg16512390 chr1:228756714 NA 0.53 6.45 0.33 3.93e-10 Chronic lymphocytic leukemia; LUSC cis rs62400317 0.859 rs62436779 chr6:45124911 G/A cg18551225 chr6:44695536 NA -0.42 -6.89 -0.35 2.76e-11 Total body bone mineral density; LUSC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg12963246 chr6:28129442 ZNF389 0.48 6.73 0.35 7.46e-11 Depression; LUSC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg00149659 chr3:10157352 C3orf10 0.91 12.29 0.56 6.74e-29 Alzheimer's disease; LUSC cis rs7615952 0.673 rs7632557 chr3:125634881 G/C cg05084668 chr3:125655381 ALG1L -0.8 -11.75 -0.54 6.33e-27 Blood pressure (smoking interaction); LUSC cis rs908922 0.676 rs1001834 chr1:152495940 C/A cg20991723 chr1:152506922 NA 0.52 9.72 0.47 7.81e-20 Hair morphology; LUSC cis rs9420 0.807 rs12807357 chr11:57656902 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.56 -0.38 3.97e-13 Schizophrenia; LUSC cis rs1448094 0.842 rs7966352 chr12:86438705 A/C cg00310523 chr12:86230176 RASSF9 0.38 6.87 0.35 3.09e-11 Major depressive disorder; LUSC cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.48 0.38 6.59e-13 Motion sickness; LUSC trans rs35110281 0.782 rs6518302 chr21:45018478 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.65 11.42 0.53 9.87e-26 Mean corpuscular volume; LUSC cis rs4803468 0.967 rs67047091 chr19:41938684 C/T cg09537434 chr19:41945824 ATP5SL 0.94 16.27 0.66 3.01e-44 Height; LUSC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg14196790 chr5:131705035 SLC22A5 0.51 8.92 0.44 3.06e-17 Blood metabolite levels; LUSC cis rs4595586 0.525 rs7136425 chr12:39376005 C/A cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs56399783 0.901 rs73033408 chr7:2879755 C/T cg19731401 chr7:2775893 GNA12 0.76 9.51 0.46 3.95e-19 Childhood ear infection; LUSC cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg18252515 chr7:66147081 NA -1.24 -13.82 -0.6 1.13e-34 Diabetic kidney disease; LUSC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.09 0.36 7.93e-12 Bipolar disorder; LUSC cis rs7106204 1.000 rs35876423 chr11:24214859 G/T ch.11.24196551F chr11:24239977 NA 0.99 9.81 0.47 4.07e-20 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11039100 0.850 rs12796660 chr11:5843681 T/C cg05234568 chr11:5960015 NA -0.52 -5.92 -0.31 7.97e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg10018233 chr7:150070692 REPIN1 0.41 6.76 0.35 6.13e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs76878669 0.538 rs73489638 chr11:66127639 C/T cg18002602 chr11:66138449 SLC29A2 -0.48 -8.44 -0.42 9.93e-16 Educational attainment (years of education); LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg09177884 chr7:1199841 ZFAND2A -0.52 -7.27 -0.37 2.54e-12 Longevity;Endometriosis; LUSC cis rs7202877 0.611 rs7187263 chr16:75308978 C/A cg04384234 chr16:75411784 CFDP1 -0.67 -9.3 -0.45 1.95e-18 Type 2 diabetes;Type 1 diabetes; LUSC cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg03146154 chr1:46216737 IPP 0.52 7.66 0.39 2e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6076065 0.748 rs6048781 chr20:23380027 T/C cg11657817 chr20:23433608 CST11 0.53 11.03 0.52 2.42e-24 Facial morphology (factor 15, philtrum width); LUSC cis rs11122272 0.735 rs2355873 chr1:231477442 A/G cg06096015 chr1:231504339 EGLN1 0.53 8.95 0.44 2.47e-17 Hemoglobin concentration; LUSC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg03806693 chr22:41940476 POLR3H -0.9 -12.72 -0.57 1.64e-30 Vitiligo; LUSC cis rs12476592 0.602 rs262484 chr2:63878015 A/G cg10828910 chr2:63850056 LOC388955 0.5 6.07 0.32 3.47e-9 Childhood ear infection; LUSC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg08859206 chr1:53392774 SCP2 -0.54 -9.35 -0.46 1.34e-18 Monocyte count; LUSC cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg26597838 chr10:835615 NA 0.9 12.25 0.56 9.21e-29 Eosinophil percentage of granulocytes; LUSC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg10802521 chr3:52805072 NEK4 -0.52 -8.33 -0.41 2.05e-15 Bipolar disorder; LUSC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg02423579 chr7:2872169 GNA12 -0.5 -7.3 -0.37 2.18e-12 Height; LUSC cis rs4887067 1 rs4887067 chr15:78886947 G/A cg18825076 chr15:78729989 IREB2 -0.49 -7.64 -0.39 2.28e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6977660 1.000 rs35784097 chr7:19818848 A/G cg05791153 chr7:19748676 TWISTNB 0.54 5.94 0.31 7.08e-9 Thyroid stimulating hormone; LUSC cis rs782590 0.967 rs782586 chr2:55836165 A/C cg18811423 chr2:55921094 PNPT1 0.83 14.47 0.62 3.58e-37 Metabolic syndrome; LUSC cis rs6570726 0.516 rs10457779 chr6:145736663 C/T cg23711669 chr6:146136114 FBXO30 0.48 7.44 0.38 8.51e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs1568889 1.000 rs7112860 chr11:28151609 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 9.16 0.45 5.39e-18 Bipolar disorder; LUSC trans rs1493916 0.870 rs8097667 chr18:31387003 C/T cg27147174 chr7:100797783 AP1S1 -0.65 -10.57 -0.5 1.04e-22 Life satisfaction; LUSC cis rs4728302 0.559 rs7779409 chr7:133158475 A/G cg10665199 chr7:133106180 EXOC4 0.58 8.16 0.41 6.67e-15 Intelligence;Intelligence (multi-trait analysis); LUSC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg19592336 chr6:28129416 ZNF389 0.45 6.0 0.31 5.12e-9 Depression; LUSC cis rs16937 0.711 rs10900470 chr1:205168614 C/T cg00857998 chr1:205179979 DSTYK 0.47 6.76 0.35 6.08e-11 Schizophrenia; LUSC cis rs7582180 0.629 rs12620139 chr2:100943446 A/G cg14675211 chr2:100938903 LONRF2 0.37 5.76 0.3 1.91e-8 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg04455712 chr21:45112962 RRP1B -0.45 -8.35 -0.42 1.9e-15 Mean corpuscular volume; LUSC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg01475377 chr6:109611718 NA -0.44 -8.07 -0.4 1.29e-14 Reticulocyte fraction of red cells; LUSC cis rs9650657 0.644 rs3808603 chr8:10698218 T/C cg27411982 chr8:10470053 RP1L1 -0.37 -6.0 -0.31 5.23e-9 Neuroticism; LUSC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC trans rs61931739 0.500 rs10844844 chr12:34380350 G/T cg13010199 chr12:38710504 ALG10B 0.64 10.1 0.48 4.04e-21 Morning vs. evening chronotype; LUSC cis rs2114646 1.000 rs2114646 chr2:170624221 C/T cg17598339 chr2:170624727 NA 0.47 5.86 0.31 1.1e-8 Obesity-related traits; LUSC cis rs1358748 0.522 rs6588239 chr1:67572361 G/A cg02640540 chr1:67518911 SLC35D1 0.67 6.47 0.33 3.46e-10 Tuberculosis; LUSC cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.85 0.39 5.59e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9814567 0.929 rs9815297 chr3:134215052 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -13.33 -0.59 8.44e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs394563 0.559 rs7753269 chr6:149671360 G/A cg07828024 chr6:149772892 ZC3H12D 0.33 7.23 0.37 3.3e-12 Dupuytren's disease; LUSC cis rs7959452 0.640 rs11177599 chr12:69721970 G/A cg11871910 chr12:69753446 YEATS4 0.67 10.29 0.49 9.66e-22 Blood protein levels; LUSC cis rs9660992 1.000 rs1779410 chr1:205248759 A/G cg21643547 chr1:205240462 TMCC2 -0.47 -9.08 -0.44 9.58e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg13126279 chr21:47581558 C21orf56 -0.48 -7.06 -0.36 9.71e-12 Testicular germ cell tumor; LUSC cis rs7481584 0.624 rs2106229 chr11:3041195 G/A cg08508325 chr11:3079039 CARS 0.36 8.1 0.41 1.02e-14 Calcium levels; LUSC cis rs854765 0.583 rs11078405 chr17:17824978 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 12.64 0.57 3.43e-30 Total body bone mineral density; LUSC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg18099408 chr3:52552593 STAB1 -0.41 -6.99 -0.36 1.46e-11 Bipolar disorder; LUSC cis rs7300001 0.538 rs7968848 chr12:110941059 T/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.5 0.38 5.91e-13 Headache; LUSC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg20503657 chr10:835505 NA 0.99 13.93 0.61 4.13e-35 Eosinophil percentage of granulocytes; LUSC trans rs60843830 1.000 rs11553746 chr2:272203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 10.2 0.49 1.96e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs3733585 0.673 rs4235347 chr4:9951956 C/T cg26043149 chr18:55253948 FECH -0.45 -6.93 -0.35 2.13e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7246967 0.551 rs1835994 chr19:22833045 T/C cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs11577318 0.626 rs11806568 chr1:26686837 C/A cg00852783 chr1:26633632 UBXN11 -0.54 -7.44 -0.38 8.85e-13 Granulocyte percentage of myeloid white cells; LUSC trans rs7939886 0.920 rs4489763 chr11:55944474 G/A cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC cis rs12900413 0.687 rs6496601 chr15:90317694 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.76 -0.3 1.92e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs7659604 0.728 rs6852923 chr4:122688324 G/A cg06713675 chr4:122721982 EXOSC9 -0.61 -10.65 -0.5 5.56e-23 Type 2 diabetes; LUSC cis rs4969178 0.600 rs4969183 chr17:76393372 A/G cg05887092 chr17:76393375 PGS1 0.66 12.88 0.58 4.22e-31 HDL cholesterol levels; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg26338869 chr17:61819248 STRADA 0.42 6.17 0.32 1.99e-9 Prudent dietary pattern; LUSC trans rs7726839 0.540 rs3749615 chr5:601485 C/T cg11887960 chr12:57824829 NA 0.54 6.7 0.34 8.62e-11 Obesity-related traits; LUSC cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg06713675 chr4:122721982 EXOSC9 -0.61 -10.57 -0.5 1.01e-22 Type 2 diabetes; LUSC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg01879757 chr17:41196368 BRCA1 -0.45 -6.84 -0.35 3.68e-11 Menopause (age at onset); LUSC cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg26384229 chr12:38710491 ALG10B 0.95 18.18 0.71 8.19e-52 Heart rate; LUSC cis rs12368653 0.544 rs11172304 chr12:58097862 T/C cg18357645 chr12:58087776 OS9 0.44 6.9 0.35 2.64e-11 Multiple sclerosis; LUSC cis rs7089973 0.872 rs7909657 chr10:116629096 C/G cg23260525 chr10:116636907 FAM160B1 0.4 8.18 0.41 5.96e-15 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs61931739 0.534 rs12372721 chr12:34175301 C/T cg06521331 chr12:34319734 NA -0.45 -7.34 -0.37 1.64e-12 Morning vs. evening chronotype; LUSC cis rs11155671 0.530 rs9383577 chr6:150207195 C/T cg13206674 chr6:150067644 NUP43 0.43 6.56 0.34 2.01e-10 Testicular germ cell tumor; LUSC cis rs9399135 0.967 rs4896121 chr6:135293645 T/C cg24558204 chr6:135376177 HBS1L 0.58 9.06 0.44 1.1e-17 Red blood cell count; LUSC cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.34 -6.22 -0.32 1.52e-9 IgG glycosylation; LUSC cis rs17155006 0.746 rs435744 chr7:107748549 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg24642844 chr7:1081250 C7orf50 -0.8 -11.08 -0.52 1.72e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg05347473 chr6:146136440 FBXO30 0.55 9.44 0.46 6.44e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg15744005 chr10:104629667 AS3MT -0.28 -5.95 -0.31 6.77e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6141769 0.866 rs79384779 chr20:31214944 C/T cg13636640 chr20:31349939 DNMT3B 0.52 5.66 0.3 3.3e-8 Subjective well-being; LUSC cis rs35123781 1.000 rs9687282 chr5:139065988 T/G cg10513866 chr5:139070639 NA 0.43 8.4 0.42 1.3e-15 Schizophrenia; LUSC trans rs1941687 0.509 rs7230319 chr18:31321289 A/T cg27147174 chr7:100797783 AP1S1 -0.52 -8.27 -0.41 3.24e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs3020736 0.500 rs4147640 chr22:42485292 T/C cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7833986 1.000 rs36088882 chr8:57092914 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 9.2 0.45 3.84e-18 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg06861087 chr14:53019167 TXNDC16;GPR137C 0.76 5.95 0.31 6.64e-9 Cognitive performance; LUSC cis rs67478160 0.634 rs2144079 chr14:104258884 C/T cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.51 -0.46 3.89e-19 Schizophrenia; LUSC trans rs7726839 0.561 rs72703044 chr5:579737 G/A cg11887960 chr12:57824829 NA 0.51 6.69 0.34 9.16e-11 Obesity-related traits; LUSC cis rs3862030 0.533 rs715440 chr10:104258095 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.62 -9.65 -0.47 1.4e-19 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs934734 0.563 rs11126034 chr2:65580221 C/T cg08085232 chr2:65598271 SPRED2 0.42 6.74 0.35 6.98e-11 Rheumatoid arthritis; LUSC cis rs9303401 0.659 rs17222621 chr17:56695923 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.85 0.6 8.46e-35 Cognitive test performance; LUSC cis rs10489202 0.954 rs11586522 chr1:168091031 G/T cg24449463 chr1:168025552 DCAF6 -0.57 -7.29 -0.37 2.32e-12 Schizophrenia; LUSC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.83 0.35 3.98e-11 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11711311 1.000 rs7622515 chr3:113472538 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.9 0.35 2.64e-11 IgG glycosylation; LUSC cis rs4812048 0.649 rs3761257 chr20:57618787 C/T cg14073986 chr20:57617431 SLMO2 0.9 9.75 0.47 6.21e-20 Mean platelet volume; LUSC cis rs10489202 1.000 rs17557135 chr1:167985888 A/G cg24449463 chr1:168025552 DCAF6 -0.59 -7.39 -0.37 1.21e-12 Schizophrenia; LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.0 -0.31 5.03e-9 Platelet count; LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg16606324 chr3:10149918 C3orf24 0.59 8.17 0.41 6.61e-15 Alzheimer's disease; LUSC trans rs72792513 1.000 rs55999417 chr2:22907370 G/A cg05844895 chr16:88969569 CBFA2T3 0.53 6.19 0.32 1.77e-9 Hepatitis B; LUSC cis rs870825 0.549 rs10015956 chr4:185614705 T/C cg04058563 chr4:185651563 MLF1IP 0.88 13.6 0.6 7.9e-34 Blood protein levels; LUSC cis rs6580649 0.941 rs78649179 chr12:48508196 T/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.09 -0.32 3.05e-9 Lung cancer; LUSC cis rs317689 0.819 rs317664 chr12:69704747 C/A cg20891283 chr12:69753455 YEATS4 0.45 6.15 0.32 2.19e-9 Response to diuretic therapy; LUSC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg03264133 chr6:25882463 NA -0.57 -9.49 -0.46 4.46e-19 Intelligence (multi-trait analysis); LUSC cis rs2970818 0.831 rs2970810 chr12:4608103 A/G cg11146114 chr12:4671731 NA -0.57 -6.06 -0.31 3.63e-9 Phosphorus levels; LUSC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.51 0.34 2.76e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1878931 0.501 rs9635547 chr16:3416664 C/T cg00484396 chr16:3507460 NAT15 -0.45 -7.42 -0.38 9.52e-13 Body mass index (adult); LUSC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg24531977 chr5:56204891 C5orf35 -0.53 -7.8 -0.39 7.87e-14 Breast cancer;Breast cancer (early onset); LUSC cis rs7173743 0.730 rs6495340 chr15:79128396 A/G cg00540400 chr15:79124168 NA 0.35 5.99 0.31 5.29e-9 Coronary artery disease; LUSC cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg23583168 chr7:148888333 NA -0.8 -13.29 -0.59 1.19e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.7 -0.34 9.08e-11 Monocyte percentage of white cells; LUSC cis rs72634258 0.945 rs12727642 chr1:8046672 C/A cg26816564 chr1:7831052 VAMP3 0.49 6.27 0.32 1.12e-9 Inflammatory bowel disease; LUSC trans rs7824557 0.591 rs2736282 chr8:11225480 C/T cg15556689 chr8:8085844 FLJ10661 0.49 7.49 0.38 6.1e-13 Retinal vascular caliber; LUSC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg13531842 chr10:38383804 ZNF37A -0.45 -6.97 -0.36 1.74e-11 Extrinsic epigenetic age acceleration; LUSC cis rs208520 0.526 rs1385219 chr6:66754476 C/T cg07460842 chr6:66804631 NA 1.21 24.67 0.8 2.96e-77 Exhaled nitric oxide output; LUSC cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg06784218 chr1:46089804 CCDC17 0.54 10.88 0.51 8.41e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1878931 0.580 rs4785932 chr16:3410456 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 17.08 0.68 1.93e-47 Body mass index (adult); LUSC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg06028605 chr16:24865363 SLC5A11 0.65 10.22 0.49 1.66e-21 Intelligence (multi-trait analysis); LUSC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg14552801 chr7:65878734 NA 0.42 5.88 0.31 9.95e-9 Aortic root size; LUSC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs929354 0.772 rs6459739 chr7:156998863 A/T cg05182265 chr7:156933206 UBE3C -0.6 -9.63 -0.47 1.59e-19 Body mass index; LUSC cis rs6714710 0.603 rs11679828 chr2:98517626 G/A cg26665480 chr2:98280029 ACTR1B 0.61 8.9 0.44 3.72e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs12681287 0.640 rs13280468 chr8:87338452 C/T cg00550725 chr8:87521180 FAM82B 0.43 5.67 0.3 3.15e-8 Caudate activity during reward; LUSC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg06618935 chr21:46677482 NA -0.39 -7.95 -0.4 2.85e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.644 rs34835603 chr4:120553428 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.53 0.34 2.38e-10 Corneal astigmatism; LUSC cis rs6565189 0.865 rs4350585 chr16:30505513 A/G cg17640201 chr16:30407289 ZNF48 0.47 6.21 0.32 1.62e-9 Tonsillectomy; LUSC cis rs9549367 0.789 rs34989271 chr13:113894766 G/A cg18105134 chr13:113819100 PROZ -0.69 -9.9 -0.48 2.05e-20 Platelet distribution width; LUSC cis rs7927592 0.913 rs6591340 chr11:68297636 A/G cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.13e-9 Total body bone mineral density; LUSC cis rs4595586 0.505 rs12826314 chr12:39379435 A/C cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs2070488 0.775 rs13098946 chr3:38517784 C/G cg24069376 chr3:38537580 EXOG 0.41 7.99 0.4 2.28e-14 Electrocardiographic conduction measures; LUSC trans rs35110281 0.744 rs162396 chr21:44947807 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.0 0.48 9.32e-21 Mean corpuscular volume; LUSC cis rs7945705 0.846 rs11042055 chr11:8756856 G/A cg09997546 chr11:8931473 C11orf17;ST5 0.32 6.13 0.32 2.54e-9 Hemoglobin concentration; LUSC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg18225595 chr11:63971243 STIP1 0.49 6.1 0.32 2.88e-9 Mean platelet volume; LUSC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg00012203 chr2:219082015 ARPC2 -0.71 -11.73 -0.54 7.42e-27 Colorectal cancer; LUSC cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg05347473 chr6:146136440 FBXO30 0.45 7.69 0.39 1.72e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs17685 0.633 rs3801471 chr7:75696188 T/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.8 -0.39 7.92e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs4654899 0.772 rs10916892 chr1:21201325 A/G cg02927042 chr1:21476669 EIF4G3 -0.37 -5.92 -0.31 8.18e-9 Superior frontal gyrus grey matter volume; LUSC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11641254 chr5:68665600 RAD17;TAF9 -0.42 -6.31 -0.33 8.9e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg00431813 chr7:1051703 C7orf50 -0.45 -7.4 -0.38 1.15e-12 Longevity;Endometriosis; LUSC cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.99 0.36 1.51e-11 Lung cancer in ever smokers; LUSC cis rs7809950 1.000 rs4730245 chr7:107087294 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.8 -0.43 7.42e-17 Coronary artery disease; LUSC cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.01 -0.44 1.61e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs714027 0.967 rs4823077 chr22:30545149 A/G cg11564601 chr22:30592435 NA -0.37 -6.81 -0.35 4.67e-11 Lymphocyte counts; LUSC cis rs7481584 0.603 rs399467 chr11:3072348 G/A cg25174290 chr11:3078921 CARS -0.41 -6.11 -0.32 2.76e-9 Calcium levels; LUSC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg03676636 chr4:99064102 C4orf37 0.34 7.48 0.38 6.43e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9473147 0.571 rs9395285 chr6:47554177 G/A cg12968598 chr6:47444699 CD2AP 0.52 7.98 0.4 2.3e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs9326248 0.954 rs8521 chr11:117067699 C/T cg26566898 chr11:117069891 TAGLN 0.45 7.93 0.4 3.38e-14 Blood protein levels; LUSC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs1023500 0.551 rs2854837 chr22:42458481 G/A cg04733989 chr22:42467013 NAGA 0.62 9.71 0.47 8.3e-20 Schizophrenia; LUSC trans rs7829975 0.711 rs4841051 chr8:8685646 C/T cg27411982 chr8:10470053 RP1L1 -0.43 -6.84 -0.35 3.85e-11 Mood instability; LUSC cis rs61931739 0.534 rs2087128 chr12:34000173 T/C cg06521331 chr12:34319734 NA -0.47 -7.61 -0.38 2.85e-13 Morning vs. evening chronotype; LUSC cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg14844989 chr11:31128820 NA -0.39 -6.03 -0.31 4.39e-9 Red blood cell count; LUSC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg23625390 chr15:77176239 SCAPER 0.46 7.04 0.36 1.09e-11 Blood metabolite levels; LUSC cis rs748404 0.697 rs572959 chr15:43550502 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.51 8.09 0.4 1.15e-14 Lung cancer; LUSC cis rs11785400 0.793 rs1056012 chr8:143740167 A/G cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs208520 0.690 rs207114 chr6:66791703 C/T cg07460842 chr6:66804631 NA -1.09 -17.42 -0.69 8.74e-49 Exhaled nitric oxide output; LUSC cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg13319975 chr6:146136371 FBXO30 0.53 8.11 0.41 9.95e-15 Lobe attachment (rater-scored or self-reported); LUSC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.75 -0.8 1.56e-77 Height; LUSC cis rs9311676 0.656 rs6799077 chr3:58404096 C/T cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.28e-10 Systemic lupus erythematosus; LUSC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg22549504 chr19:17448937 GTPBP3 -0.54 -7.1 -0.36 7.38e-12 Systemic lupus erythematosus; LUSC trans rs208515 0.525 rs9453538 chr6:66668508 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.03 14.08 0.61 1.14e-35 Exhaled nitric oxide levels; LUSC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg05084668 chr3:125655381 ALG1L -0.53 -8.06 -0.4 1.42e-14 Blood pressure (smoking interaction); LUSC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg08499158 chr17:42289980 UBTF -0.49 -8.24 -0.41 4.03e-15 Total body bone mineral density; LUSC cis rs75804782 0.641 rs72985397 chr2:239341354 A/G cg18131467 chr2:239335373 ASB1 -0.68 -6.25 -0.32 1.29e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.0 -0.44 1.72e-17 Monocyte percentage of white cells; LUSC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg14895029 chr7:2775587 GNA12 -0.36 -5.87 -0.31 1.08e-8 Height; LUSC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg18806716 chr10:30721971 MAP3K8 -0.7 -11.12 -0.52 1.15e-24 Inflammatory bowel disease; LUSC cis rs67072384 1.000 rs11235577 chr11:72451380 C/T cg04827223 chr11:72435913 ARAP1 -0.76 -6.53 -0.34 2.39e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs427941 0.703 rs201448 chr7:101738860 T/C cg06246474 chr7:101738831 CUX1 0.41 6.71 0.34 8.45e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg25643088 chr3:52874325 TMEM110 0.4 5.97 0.31 6.08e-9 Schizophrenia; LUSC cis rs1153858 1.000 rs1613559 chr15:45622116 A/G cg14582100 chr15:45693742 SPATA5L1 0.58 10.18 0.49 2.23e-21 Homoarginine levels; LUSC cis rs6700896 0.931 rs4655574 chr1:66135328 T/A cg04111102 chr1:66153794 NA 0.33 7.22 0.37 3.53e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg24399712 chr22:39784796 NA -0.63 -11.31 -0.53 2.43e-25 Intelligence (multi-trait analysis); LUSC cis rs9302635 0.513 rs8044555 chr16:72152755 T/C cg01557791 chr16:72042693 DHODH -0.48 -6.18 -0.32 1.92e-9 Blood protein levels; LUSC cis rs4363385 0.747 rs1015996 chr1:152976108 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.76 -0.39 1.05e-13 Inflammatory skin disease; LUSC cis rs7241530 0.662 rs6506754 chr18:75904989 A/G cg14642773 chr18:75888474 NA 0.39 5.94 0.31 7.29e-9 Educational attainment (years of education); LUSC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg11062466 chr8:58055876 NA 0.51 6.48 0.33 3.36e-10 Developmental language disorder (linguistic errors); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg18452880 chr6:170151829 C6orf70;TCTE3 -0.5 -6.35 -0.33 7.2e-10 Bipolar disorder and schizophrenia; LUSC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg17764715 chr19:33622953 WDR88 0.59 8.53 0.42 5e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg07959070 chr22:50026188 C22orf34 -0.34 -7.03 -0.36 1.13e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6681460 1.000 rs7524818 chr1:67072031 C/T cg02459107 chr1:67143332 SGIP1 0.5 9.24 0.45 2.89e-18 Presence of antiphospholipid antibodies; LUSC cis rs7903847 0.620 rs11189168 chr10:99125769 T/C cg20016023 chr10:99160130 RRP12 -0.34 -8.16 -0.41 6.97e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.95 -16.93 -0.68 7.57e-47 Chronic sinus infection; LUSC cis rs12410462 0.901 rs2814090 chr1:227658444 C/G cg23173402 chr1:227635558 NA -0.46 -5.73 -0.3 2.2e-8 Major depressive disorder; LUSC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg07148914 chr20:33460835 GGT7 0.43 6.28 0.33 1.04e-9 Coronary artery disease; LUSC trans rs1994135 0.669 rs10844628 chr12:33697065 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.62 0.34 1.39e-10 Resting heart rate; LUSC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg01368799 chr11:117014884 PAFAH1B2 0.59 9.24 0.45 3.06e-18 Blood protein levels; LUSC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg18099408 chr3:52552593 STAB1 -0.42 -7.28 -0.37 2.44e-12 Electroencephalogram traits; LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg21724239 chr8:58056113 NA 0.69 8.86 0.44 4.93e-17 Developmental language disorder (linguistic errors); LUSC cis rs250677 0.522 rs12520924 chr5:148349149 C/T cg18129178 chr5:148520854 ABLIM3 0.54 7.3 0.37 2.16e-12 Breast cancer; LUSC cis rs11048434 0.736 rs12823100 chr12:9108908 C/A cg13575925 chr12:9217583 LOC144571 0.35 6.43 0.33 4.51e-10 Sjögren's syndrome; LUSC trans rs1005277 0.579 rs11011461 chr10:38431427 G/A cg17830980 chr10:43048298 ZNF37B -0.58 -9.39 -0.46 9.51e-19 Extrinsic epigenetic age acceleration; LUSC cis rs75920871 0.588 rs7112111 chr11:116980858 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.55 -7.0 -0.36 1.43e-11 Subjective well-being; LUSC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg04553112 chr3:125709451 NA -0.5 -5.66 -0.3 3.27e-8 Blood pressure (smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05039583 chr15:75660780 MAN2C1 -0.42 -6.12 -0.32 2.64e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2050392 0.799 rs2907 chr10:30728250 A/G cg18806716 chr10:30721971 MAP3K8 -0.48 -8.01 -0.4 1.93e-14 Inflammatory bowel disease; LUSC cis rs9905704 0.914 rs34556895 chr17:56826953 G/T cg12560992 chr17:57184187 TRIM37 0.56 7.89 0.4 4.39e-14 Testicular germ cell tumor; LUSC cis rs911186 0.730 rs2393911 chr6:27057079 C/T cg12292205 chr6:26970375 C6orf41 -0.63 -8.74 -0.43 1.12e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs6701037 1.000 rs6659824 chr1:175125378 C/A cg17845761 chr1:175162550 KIAA0040 -0.31 -6.0 -0.31 5.07e-9 Alcohol dependence; LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg13395646 chr4:1353034 KIAA1530 -0.58 -8.19 -0.41 5.62e-15 Longevity; LUSC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg19592336 chr6:28129416 ZNF389 0.46 6.01 0.31 4.81e-9 Depression; LUSC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg18681998 chr4:17616180 MED28 0.88 17.23 0.69 4.87e-48 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3931020 0.657 rs7522428 chr1:75178360 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.63 8.39 0.42 1.43e-15 Resistin levels; LUSC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.935 rs7479914 chr11:49661351 T/C cg15704280 chr7:45808275 SEPT13 -1.09 -22.35 -0.77 2.54e-68 Height; LUSC trans rs7951105 1.000 rs2220444 chr11:39247768 A/G cg24085930 chr3:21832523 NA 0.5 6.24 0.32 1.33e-9 Free thyroxine concentration; LUSC cis rs6500602 0.929 rs6500603 chr16:4497537 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 6.33 0.33 7.99e-10 Schizophrenia; LUSC cis rs1034435 0.755 rs5768680 chr22:48892919 T/C cg05992904 chr22:48892994 FAM19A5 -0.41 -8.16 -0.41 6.85e-15 Late-onset Alzheimer's disease; LUSC trans rs877282 0.583 rs11253441 chr10:828288 C/T cg13042288 chr15:90349979 ANPEP 0.4 6.06 0.31 3.73e-9 Uric acid levels; LUSC cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -7.47 -0.38 6.88e-13 Personality dimensions; LUSC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg17971929 chr21:40555470 PSMG1 -0.69 -11.31 -0.53 2.42e-25 Cognitive function; LUSC trans rs11098499 0.866 rs13105020 chr4:120285688 G/T cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC trans rs11088226 1.000 rs11701627 chr21:33927794 T/A cg09050820 chr6:167586206 TCP10L2 0.54 7.19 0.37 4.38e-12 Gastritis; LUSC cis rs13092825 1.000 rs7623311 chr3:113284698 A/C cg18753928 chr3:113234510 CCDC52 -0.38 -5.65 -0.3 3.45e-8 Dental caries; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg09033563 chr22:24373618 LOC391322 -0.69 -10.72 -0.51 2.94e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1865721 1.000 rs62089507 chr18:73179019 C/T cg26385618 chr18:73139727 C18orf62 -0.48 -8.19 -0.41 5.65e-15 Intelligence; LUSC trans rs1448094 0.791 rs10863110 chr12:86328523 T/C cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.39 -0.46 9.83e-19 Schizophrenia; LUSC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7712401 0.601 rs13164134 chr5:122337941 T/A cg19077854 chr5:122220652 SNX24 -0.43 -9.22 -0.45 3.4e-18 Mean platelet volume; LUSC cis rs62400317 0.859 rs58769170 chr6:45298531 C/T cg18551225 chr6:44695536 NA -0.45 -7.44 -0.38 8.38e-13 Total body bone mineral density; LUSC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11644478 chr21:40555479 PSMG1 0.93 18.06 0.7 2.35e-51 Cognitive function; LUSC cis rs6121246 0.529 rs6060291 chr20:30198043 T/G cg13852791 chr20:30311386 BCL2L1 0.73 8.34 0.42 2.01e-15 Mean corpuscular hemoglobin; LUSC trans rs7937682 0.632 rs4441050 chr11:111772506 C/T cg18187862 chr3:45730750 SACM1L -0.54 -6.6 -0.34 1.62e-10 Primary sclerosing cholangitis; LUSC cis rs4700695 0.668 rs153393 chr5:65428707 A/G cg21114390 chr5:65439923 SFRS12 -0.6 -8.22 -0.41 4.44e-15 Facial morphology (factor 19); LUSC trans rs853679 0.567 rs13209596 chr6:28396190 C/A cg01620082 chr3:125678407 NA -0.42 -6.27 -0.32 1.13e-9 Depression; LUSC cis rs921968 0.509 rs72963905 chr2:219547027 T/G cg02176678 chr2:219576539 TTLL4 -0.73 -14.0 -0.61 2.25e-35 Mean corpuscular hemoglobin concentration; LUSC cis rs11098499 0.645 rs72676059 chr4:120290828 C/G cg09307838 chr4:120376055 NA 0.69 10.35 0.49 5.71e-22 Corneal astigmatism; LUSC cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg26769984 chr7:1090371 C7orf50 0.45 6.76 0.35 6.08e-11 Bronchopulmonary dysplasia; LUSC cis rs9467711 0.591 rs17586553 chr6:25928775 C/T cg08501292 chr6:25962987 TRIM38 0.69 6.56 0.34 2.07e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg27068330 chr11:65405492 SIPA1 -0.46 -5.92 -0.31 7.94e-9 Breast cancer; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg15147215 chr3:52552868 STAB1 -0.33 -6.51 -0.34 2.79e-10 Bipolar disorder; LUSC cis rs9929218 0.954 rs9928796 chr16:68820718 A/G cg02972257 chr16:68554789 NA 0.41 5.73 0.3 2.19e-8 Colorectal cancer; LUSC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg16362232 chr11:430036 ANO9 0.66 8.17 0.41 6.51e-15 Body mass index; LUSC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg01475377 chr6:109611718 NA -0.46 -8.44 -0.42 1e-15 Reticulocyte fraction of red cells; LUSC cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.79 -0.51 1.71e-23 Chronic sinus infection; LUSC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg07716408 chr11:68623521 NA -0.3 -5.66 -0.3 3.2e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs617219 0.787 rs12189006 chr5:78539672 G/T cg24856658 chr5:78533917 JMY -0.3 -5.86 -0.31 1.12e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg07636037 chr3:49044803 WDR6 1.05 17.32 0.69 2.13e-48 Parkinson's disease; LUSC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg22508957 chr16:3507546 NAT15 -0.4 -6.18 -0.32 1.92e-9 Body mass index (adult); LUSC cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.59 -0.46 2.18e-19 Chronic sinus infection; LUSC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg05425664 chr17:57184151 TRIM37 -0.55 -8.29 -0.41 2.7e-15 Intelligence (multi-trait analysis); LUSC cis rs244293 0.965 rs244287 chr17:53232036 C/T cg19360675 chr17:53046073 COX11;STXBP4 0.4 5.78 0.3 1.73e-8 Menarche (age at onset); LUSC cis rs4843185 0.637 rs4143866 chr16:85716366 A/G cg26571870 chr16:85723150 GINS2 -0.34 -5.97 -0.31 6.08e-9 Platelet distribution width; LUSC cis rs11585357 0.947 rs3003441 chr1:17611869 C/T cg08277548 chr1:17600880 PADI3 0.63 6.78 0.35 5.57e-11 Hair shape; LUSC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg09359103 chr1:154839909 KCNN3 -0.69 -15.84 -0.65 1.53e-42 Prostate cancer; LUSC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg08888203 chr3:10149979 C3orf24 0.59 8.28 0.41 2.93e-15 Alzheimer's disease; LUSC cis rs10489202 0.632 rs203781 chr1:167880518 A/C cg24449463 chr1:168025552 DCAF6 -0.72 -11.51 -0.53 4.79e-26 Schizophrenia; LUSC cis rs3942852 0.868 rs58407618 chr11:48104167 T/G cg20307385 chr11:47447363 PSMC3 0.52 6.2 0.32 1.71e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg17971929 chr21:40555470 PSMG1 0.76 12.72 0.57 1.71e-30 Cognitive function; LUSC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg04369109 chr6:150039330 LATS1 0.59 8.76 0.43 9.63e-17 Lung cancer; LUSC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg02569458 chr12:86230093 RASSF9 0.54 9.21 0.45 3.78e-18 Major depressive disorder; LUSC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg11062466 chr8:58055876 NA 0.76 9.09 0.45 9.22e-18 Developmental language disorder (linguistic errors); LUSC cis rs3820068 0.608 rs10927836 chr1:16034368 G/C cg13390004 chr1:15929781 NA 0.42 6.82 0.35 4.38e-11 Systolic blood pressure; LUSC cis rs79349575 0.783 rs4794000 chr17:47022755 C/G cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC cis rs12478296 0.792 rs57482298 chr2:243011148 C/A cg06360820 chr2:242988706 NA -1.01 -10.85 -0.51 1.11e-23 Obesity-related traits; LUSC cis rs11785400 1.000 rs4266629 chr8:143736635 A/G cg10596483 chr8:143751796 JRK 0.61 9.39 0.46 9.87e-19 Schizophrenia; LUSC trans rs8072100 0.748 rs9912592 chr17:45556945 G/A cg04995722 chr7:26192034 NFE2L3 -0.43 -6.64 -0.34 1.24e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1018836 0.923 rs4735230 chr8:91574184 G/C cg16814680 chr8:91681699 NA -0.76 -12.82 -0.57 6.92e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs240764 0.717 rs1039032 chr6:101161931 T/C cg09795085 chr6:101329169 ASCC3 -0.42 -6.09 -0.32 3.03e-9 Neuroticism; LUSC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.86 -0.35 3.25e-11 Tonsillectomy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10314172 chr2:64681735 HSPC159 0.45 6.1 0.32 3e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg16680214 chr1:154839983 KCNN3 -0.52 -9.8 -0.47 4.2e-20 Prostate cancer; LUSC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg04267008 chr7:1944627 MAD1L1 -0.62 -9.39 -0.46 9.41e-19 Bipolar disorder and schizophrenia; LUSC cis rs7819412 0.745 rs6601569 chr8:11073578 C/T cg21775007 chr8:11205619 TDH -0.54 -7.7 -0.39 1.5700000000000001e-13 Triglycerides; LUSC cis rs10876993 0.928 rs1678540 chr12:58065002 A/G cg15848620 chr12:58087721 OS9 -0.54 -7.89 -0.4 4.33e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg12590608 chr7:158785262 NA 0.32 6.07 0.32 3.48e-9 Facial morphology (factor 20); LUSC trans rs12043259 1.000 rs12239961 chr1:204827537 C/A cg23865240 chr7:27134109 HOXA1 -0.53 -6.01 -0.31 4.8e-9 Addiction; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg07424592 chr7:64974309 NA -0.45 -6.38 -0.33 5.82e-10 Calcium levels; LUSC cis rs7223966 1.000 rs11657081 chr17:61792339 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.14 0.32 2.33e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg13298116 chr11:62369859 EML3;MTA2 0.59 9.62 0.47 1.7e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg11279151 chr3:101281821 RG9MTD1 -0.39 -5.68 -0.3 2.93e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs10089 0.953 rs4836358 chr5:127376869 A/G cg19767477 chr5:127420684 SLC12A2 -0.4 -5.74 -0.3 2.12e-8 Ileal carcinoids; LUSC trans rs4689388 0.890 rs4689398 chr4:6302199 C/T cg17567195 chr5:167378696 ODZ2 -0.38 -6.03 -0.31 4.23e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4073582 1.000 rs801732 chr11:65935502 T/A cg16950941 chr11:66035639 RAB1B 0.45 5.86 0.31 1.13e-8 Gout; LUSC cis rs9788682 0.747 rs2036533 chr15:78781687 G/A cg18825076 chr15:78729989 IREB2 0.46 6.45 0.33 4.04e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs7937682 0.924 rs7924683 chr11:111555796 C/A cg19812747 chr11:111475976 SIK2 -0.5 -7.05 -0.36 1.03e-11 Primary sclerosing cholangitis; LUSC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.73 -0.39 1.26e-13 Lymphocyte counts; LUSC cis rs72781680 0.752 rs72796110 chr2:23905658 T/A cg08917208 chr2:24149416 ATAD2B 0.98 9.71 0.47 8.25e-20 Lymphocyte counts; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05109266 chr11:810147 RPLP2 0.77 6.32 0.33 8.36e-10 Cognitive performance; LUSC trans rs11098499 0.955 rs11944880 chr4:120159334 A/G cg25214090 chr10:38739885 LOC399744 -0.43 -6.37 -0.33 6.28e-10 Corneal astigmatism; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.23 0.56 1.17e-28 Prudent dietary pattern; LUSC cis rs10744422 1.000 rs10847869 chr12:123328359 C/G cg25930673 chr12:123319894 HIP1R -0.63 -6.23 -0.32 1.41e-9 Schizophrenia; LUSC cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.42 -6.51 -0.34 2.77e-10 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2658782 0.547 rs3133454 chr11:93059019 A/C cg15737290 chr11:93063684 CCDC67 0.89 13.58 0.6 9.2e-34 Pulmonary function decline; LUSC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg22709100 chr7:91322751 NA 0.4 5.73 0.3 2.29e-8 Breast cancer; LUSC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs61931739 0.500 rs9919726 chr12:34510783 A/G cg13010199 chr12:38710504 ALG10B 0.57 9.09 0.45 9.21e-18 Morning vs. evening chronotype; LUSC cis rs10089 1.000 rs13357268 chr5:127423051 G/A cg19767477 chr5:127420684 SLC12A2 -0.43 -5.9 -0.31 8.87e-9 Ileal carcinoids; LUSC cis rs7615316 0.751 rs11925693 chr3:142153453 A/G cg16271453 chr3:142027066 XRN1 -0.43 -7.42 -0.38 9.9e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs11088226 0.846 rs2833884 chr21:33923075 A/G cg09050820 chr6:167586206 TCP10L2 0.65 9.88 0.48 2.25e-20 Gastritis; LUSC cis rs6831352 0.918 rs2213035 chr4:100064233 G/A cg12011299 chr4:100065546 ADH4 -0.73 -10.73 -0.51 2.92e-23 Alcohol dependence; LUSC cis rs2481665 1.000 rs2481665 chr1:62594677 T/C cg18591186 chr1:62594603 INADL -0.55 -8.78 -0.43 8.62e-17 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.49e-11 Schizophrenia; LUSC trans rs7980799 0.649 rs2389218 chr12:33680929 C/A cg26384229 chr12:38710491 ALG10B 0.57 8.2 0.41 5.22e-15 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg07424592 chr7:64974309 NA -0.63 -5.65 -0.3 3.53e-8 Diabetic kidney disease; LUSC cis rs599083 0.590 rs10791984 chr11:68407835 T/G cg16797656 chr11:68205561 LRP5 -0.4 -7.1 -0.36 7.5e-12 Bone mineral density (spine); LUSC cis rs2692947 0.673 rs3111873 chr2:96781986 G/C cg23100626 chr2:96804247 ASTL -0.3 -7.28 -0.37 2.47e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg14844989 chr11:31128820 NA -0.37 -5.77 -0.3 1.81e-8 Red blood cell count; LUSC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg00166722 chr3:10149974 C3orf24 0.55 7.46 0.38 7.77e-13 Alzheimer's disease; LUSC cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg23583168 chr7:148888333 NA -0.88 -16.71 -0.67 5.44e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1866706 0.896 rs4757957 chr11:12881398 C/G cg25843174 chr11:12811716 TEAD1 -0.28 -5.93 -0.31 7.65e-9 Intelligence (multi-trait analysis); LUSC cis rs2742417 1.000 rs2742389 chr3:45756683 G/C cg04837898 chr3:45731254 SACM1L -0.34 -5.73 -0.3 2.26e-8 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2742417 1.000 rs2673065 chr3:45771222 C/T cg09608765 chr3:45636137 LIMD1 -0.37 -7.39 -0.37 1.17e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.52 -0.34 2.59e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.36 -5.82 -0.3 1.41e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs748404 0.690 rs2244981 chr15:43752751 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC trans rs7824557 0.545 rs34482136 chr8:11227885 C/T cg08975724 chr8:8085496 FLJ10661 -0.49 -7.17 -0.37 4.79e-12 Retinal vascular caliber; LUSC trans rs11700980 0.551 rs2251447 chr21:30109202 C/G cg14791747 chr16:20752902 THUMPD1 0.56 6.1 0.32 2.88e-9 QRS complex (12-leadsum); LUSC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg25456477 chr12:86230367 RASSF9 0.33 5.8 0.3 1.55e-8 Major depressive disorder; LUSC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg24531977 chr5:56204891 C5orf35 -0.69 -10.01 -0.48 8.66e-21 Coronary artery disease; LUSC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg18230493 chr5:56204884 C5orf35 0.66 10.14 0.49 3.04e-21 Coronary artery disease; LUSC cis rs1107366 0.695 rs10934754 chr3:125906237 T/C cg01346077 chr3:125931526 NA 0.34 6.44 0.33 4.06e-10 Metabolite levels; LUSC trans rs1062753 0.771 rs932376 chr22:42614362 T/C cg02551029 chr5:82767394 VCAN -0.4 -6.18 -0.32 1.83e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs2273669 0.667 rs78550764 chr6:109312239 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs9527 0.590 rs1475642 chr10:104546183 C/T cg05855489 chr10:104503620 C10orf26 -0.66 -9.42 -0.46 7.63e-19 Arsenic metabolism; LUSC cis rs4660306 0.672 rs534534 chr1:46024701 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.03 -0.31 4.3e-9 Homocysteine levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg21605859 chr18:48723183 MEX3C -0.42 -6.25 -0.32 1.22e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.77 -0.35 5.67e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg08677398 chr8:58056175 NA 0.53 6.47 0.33 3.43e-10 Developmental language disorder (linguistic errors); LUSC cis rs9486715 0.867 rs9384602 chr6:96919561 G/A cg06623918 chr6:96969491 KIAA0776 0.94 17.59 0.69 1.81e-49 Headache; LUSC cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg12011299 chr4:100065546 ADH4 0.7 10.53 0.5 1.36e-22 Smoking initiation; LUSC cis rs1403694 0.695 rs3774291 chr3:186433471 C/T cg12454167 chr3:186435060 KNG1 0.34 8.42 0.42 1.15e-15 Blood protein levels; LUSC cis rs78707713 0.560 rs61848397 chr10:71225584 C/A cg12610070 chr10:71211762 TSPAN15 -0.5 -9.42 -0.46 7.88e-19 Venous thromboembolism; LUSC cis rs3935685 0.967 rs62009151 chr15:77999264 C/A cg25212270 chr15:78015279 NA 0.29 6.4 0.33 5.28e-10 Intelligence (multi-trait analysis); LUSC cis rs7759001 0.817 rs2206250 chr6:27355842 A/C cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.63 -8.5 -0.42 6.54e-16 Multiple sclerosis; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg16362232 chr11:430036 ANO9 0.64 8.16 0.41 7.08e-15 Body mass index; LUSC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs1595825 0.891 rs73054827 chr2:198649905 G/A cg19156104 chr2:198669113 PLCL1 -0.46 -5.66 -0.3 3.3e-8 Ulcerative colitis; LUSC cis rs12200560 0.505 rs211171 chr6:97070579 T/G cg06623918 chr6:96969491 KIAA0776 0.49 7.07 0.36 8.98e-12 Coronary heart disease; LUSC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg20203395 chr5:56204925 C5orf35 -0.64 -8.91 -0.44 3.34e-17 Initial pursuit acceleration; LUSC cis rs2239547 0.522 rs6792578 chr3:53004604 G/A cg18404041 chr3:52824283 ITIH1 -0.55 -9.44 -0.46 6.59e-19 Schizophrenia; LUSC cis rs7098414 0.511 rs10887828 chr10:82151470 T/C cg01528321 chr10:82214614 TSPAN14 0.61 9.07 0.44 1.06e-17 Post bronchodilator FEV1; LUSC cis rs12760731 0.565 rs12048698 chr1:178136792 T/C cg00404053 chr1:178313656 RASAL2 0.68 6.84 0.35 3.78e-11 Obesity-related traits; LUSC cis rs2273669 0.588 rs11153151 chr6:109316754 C/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg02503808 chr4:7069936 GRPEL1 0.88 10.52 0.5 1.53e-22 Monocyte percentage of white cells; LUSC cis rs7582180 0.629 rs12621892 chr2:100947124 G/C cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs400736 0.602 rs6694154 chr1:8163520 G/A cg25007680 chr1:8021821 PARK7 -0.45 -6.75 -0.35 6.58e-11 Response to antidepressants and depression; LUSC trans rs1171606 0.738 rs3763747 chr10:61412335 A/G cg14119616 chr11:17099403 RPS13 -0.41 -5.94 -0.31 6.99e-9 Acylcarnitine levels; LUSC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg14343924 chr8:8086146 FLJ10661 -0.42 -5.79 -0.3 1.59e-8 Mood instability; LUSC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg23172400 chr8:95962367 TP53INP1 -0.4 -8.07 -0.4 1.31e-14 Type 2 diabetes; LUSC cis rs422249 0.512 rs174561 chr11:61582708 T/C cg19610905 chr11:61596333 FADS2 -0.54 -7.88 -0.4 4.52e-14 Trans fatty acid levels; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg12232778 chr20:56324064 NA 0.49 5.95 0.31 6.7e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2404602 0.647 rs2404600 chr15:77173557 C/T cg23625390 chr15:77176239 SCAPER -0.66 -9.91 -0.48 1.79e-20 Blood metabolite levels; LUSC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg07701084 chr6:150067640 NUP43 0.56 8.43 0.42 1.07e-15 Lung cancer; LUSC cis rs6964587 0.967 rs6974827 chr7:91772945 C/T cg01689657 chr7:91764605 CYP51A1 0.32 5.89 0.31 9.34e-9 Breast cancer; LUSC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.45 0.53 7.58e-26 Prudent dietary pattern; LUSC cis rs1355223 0.867 rs7925421 chr11:34681677 G/A cg11058730 chr11:34937778 PDHX;APIP -0.4 -5.65 -0.3 3.53e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg22467129 chr15:76604101 ETFA -0.46 -7.24 -0.37 3.2e-12 Blood metabolite levels; LUSC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg06873352 chr17:61820015 STRADA -0.72 -12.97 -0.58 1.92e-31 Prudent dietary pattern; LUSC cis rs1577917 1.000 rs4706254 chr6:86602813 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.48e-15 Response to antipsychotic treatment; LUSC cis rs2806561 0.765 rs1757046 chr1:23511821 T/C cg19743168 chr1:23544995 NA 0.4 7.69 0.39 1.72e-13 Height; LUSC trans rs2790216 0.526 rs1199093 chr10:59896794 C/G cg14931586 chr11:85780345 PICALM -0.35 -6.1 -0.32 2.86e-9 Inflammatory bowel disease; LUSC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg12311346 chr5:56204834 C5orf35 -0.66 -10.02 -0.48 7.91e-21 Coronary artery disease; LUSC trans rs6429422 0.725 rs2787232 chr1:243306475 G/C cg25284624 chr1:224180302 NA 0.47 7.36 0.37 1.48e-12 Cognitive ability (multi-trait analysis); LUSC cis rs5753618 0.561 rs2283879 chr22:31638448 G/A cg22777020 chr22:31556080 RNF185 -0.45 -5.79 -0.3 1.6e-8 Colorectal cancer; LUSC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg06238570 chr21:40685208 BRWD1 -0.55 -8.53 -0.42 5.28e-16 Menarche (age at onset); LUSC cis rs240764 0.658 rs11155637 chr6:101203592 A/G cg09795085 chr6:101329169 ASCC3 -0.44 -6.46 -0.33 3.67e-10 Neuroticism; LUSC cis rs10751667 0.666 rs4072741 chr11:976565 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.3 0.33 9.2e-10 Alzheimer's disease (late onset); LUSC cis rs6867032 0.834 rs4526149 chr5:1990166 G/A cg26168224 chr5:2018326 NA -0.72 -12.31 -0.56 5.78e-29 Gut microbiome composition (winter); LUSC cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg26384229 chr12:38710491 ALG10B 0.63 10.03 0.48 7.4e-21 Morning vs. evening chronotype; LUSC cis rs12931792 0.682 rs12373078 chr16:30187676 T/G cg17640201 chr16:30407289 ZNF48 0.61 9.82 0.47 3.61e-20 Tonsillectomy; LUSC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg09365446 chr1:150670422 GOLPH3L 0.53 8.27 0.41 3.25e-15 Tonsillectomy; LUSC cis rs7107174 1.000 rs4134379 chr11:77992588 A/G cg02023728 chr11:77925099 USP35 0.45 6.7 0.34 9.1e-11 Testicular germ cell tumor; LUSC cis rs4290604 0.665 rs6761002 chr2:238038873 T/C cg23555395 chr2:238036564 NA -0.55 -7.2 -0.37 3.91e-12 Asthma; LUSC trans rs7937682 0.575 rs7107213 chr11:111750430 A/G cg18187862 chr3:45730750 SACM1L -0.5 -6.18 -0.32 1.82e-9 Primary sclerosing cholangitis; LUSC cis rs7223966 1.000 rs6504170 chr17:61709168 C/T cg05941027 chr17:61774174 LIMD2 0.24 6.6 0.34 1.59e-10 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs853679 0.517 rs3734573 chr6:28059437 T/C cg06606381 chr12:133084897 FBRSL1 -0.45 -6.08 -0.32 3.31e-9 Depression; LUSC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg07936489 chr17:37558343 FBXL20 0.85 11.14 0.52 1e-24 Glomerular filtration rate (creatinine); LUSC cis rs3126085 0.935 rs11204941 chr1:152203343 A/G cg26876637 chr1:152193138 HRNR 0.46 6.57 0.34 1.89e-10 Atopic dermatitis; LUSC cis rs11608355 0.545 rs11066782 chr12:109910552 C/T cg05360138 chr12:110035743 NA 0.88 11.29 0.53 2.95e-25 Neuroticism; LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg18110333 chr6:292329 DUSP22 -0.53 -7.97 -0.4 2.57e-14 Menopause (age at onset); LUSC cis rs9948 0.655 rs62156210 chr2:97393736 A/T cg01990225 chr2:97406019 LMAN2L -1.03 -7.11 -0.36 7.29e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs1062746 0.520 rs17770996 chr16:87330207 G/A cg02258303 chr16:87377426 FBXO31 -0.52 -7.79 -0.39 8.46e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg26039829 chr8:22132926 PIWIL2 -0.43 -8.11 -0.41 1e-14 Hypertriglyceridemia; LUSC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.18 0.37 4.5e-12 Bipolar disorder; LUSC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg18876405 chr7:65276391 NA 0.54 8.27 0.41 3.22e-15 Aortic root size; LUSC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg02782426 chr3:40428986 ENTPD3 0.39 7.01 0.36 1.33e-11 Renal cell carcinoma; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg10360139 chr7:1886902 MAD1L1 -0.4 -5.96 -0.31 6.3e-9 Bipolar disorder and schizophrenia; LUSC cis rs6121246 0.567 rs7361893 chr20:30200751 C/T cg21427119 chr20:30132790 HM13 -0.46 -6.65 -0.34 1.23e-10 Mean corpuscular hemoglobin; LUSC cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg13395646 chr4:1353034 KIAA1530 -0.67 -11.62 -0.54 1.95e-26 Longevity; LUSC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg03929089 chr4:120376271 NA -0.5 -6.92 -0.35 2.34e-11 HDL cholesterol; LUSC cis rs4356932 1.000 rs8878 chr4:76942300 C/T cg00809888 chr4:76862425 NAAA -0.35 -5.73 -0.3 2.29e-8 Blood protein levels; LUSC cis rs4689388 0.890 rs4501291 chr4:6298582 C/T cg14416269 chr4:6271139 WFS1 0.52 10.7 0.51 3.6e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg05872129 chr22:39784769 NA -0.6 -10.98 -0.51 3.82e-24 Intelligence (multi-trait analysis); LUSC cis rs17685 0.753 rs6951943 chr7:75772452 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.74e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.68 10.27 0.49 1.11e-21 Lymphocyte counts; LUSC cis rs8005677 1.000 rs4982709 chr14:23394699 C/T cg23176270 chr14:23476067 C14orf93 0.37 6.02 0.31 4.68e-9 Cognitive ability (multi-trait analysis); LUSC cis rs7592578 0.771 rs10432434 chr2:191387079 T/G cg10560079 chr2:191398806 TMEM194B -0.75 -9.1 -0.45 8.61e-18 Diastolic blood pressure; LUSC trans rs4718428 0.705 rs62465692 chr7:66295745 T/C cg18876405 chr7:65276391 NA 0.48 6.53 0.34 2.39e-10 Corneal structure; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.89 0.55 2.01e-27 Prudent dietary pattern; LUSC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg08244238 chr11:790193 CEND1 0.4 6.9 0.35 2.59e-11 Breast cancer; LUSC cis rs9486715 0.790 rs2971602 chr6:97022468 C/T cg06623918 chr6:96969491 KIAA0776 -0.93 -17.57 -0.69 2.04e-49 Headache; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09859293 chr2:3605851 RNASEH1 -0.49 -5.99 -0.31 5.49e-9 Bipolar disorder and schizophrenia; LUSC cis rs7264396 0.563 rs2425117 chr20:34323776 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.49 -0.42 7e-16 Total cholesterol levels; LUSC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg11764359 chr7:65958608 NA 0.53 6.79 0.35 5.17e-11 Aortic root size; LUSC cis rs6918586 0.658 rs13161 chr6:26114702 C/T cg17691542 chr6:26056736 HIST1H1C 0.4 5.9 0.31 9.13e-9 Schizophrenia; LUSC cis rs10465746 0.901 rs17475760 chr1:84398435 A/T cg10977910 chr1:84465055 TTLL7 0.44 6.42 0.33 4.58e-10 Obesity-related traits; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02278959 chr17:18576472 ZNF286B;FOXO3B -0.5 -6.1 -0.32 2.89e-9 Bipolar disorder and schizophrenia; LUSC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg14983838 chr19:29218262 NA 0.65 9.51 0.46 3.84e-19 Methadone dose in opioid dependence; LUSC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg19622623 chr12:86230825 RASSF9 -0.44 -6.32 -0.33 8.47e-10 Major depressive disorder; LUSC cis rs2274273 0.934 rs10144418 chr14:55817708 T/C cg04306507 chr14:55594613 LGALS3 0.53 11.47 0.53 6.66e-26 Protein biomarker; LUSC cis rs9807989 0.839 rs4851565 chr2:102971481 C/A cg03938978 chr2:103052716 IL18RAP 0.32 5.88 0.31 9.76e-9 Asthma; LUSC cis rs11158026 0.757 rs17128120 chr14:55474598 C/T cg04306507 chr14:55594613 LGALS3 0.37 7.27 0.37 2.57e-12 Parkinson's disease; LUSC cis rs1577917 0.958 rs12205492 chr6:86475976 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.97 -0.36 1.7e-11 Response to antipsychotic treatment; LUSC trans rs12043259 1.000 rs12239394 chr1:204825794 A/C cg23865240 chr7:27134109 HOXA1 -0.53 -6.01 -0.31 4.8e-9 Addiction; LUSC cis rs4901869 0.932 rs12878445 chr14:59339361 A/G cg02291164 chr14:59296302 NA 0.58 11.11 0.52 1.33e-24 Panic disorder; LUSC cis rs6582630 0.538 rs12305104 chr12:38336353 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.15 -0.32 2.26e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.72 -0.43 1.34e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg13560548 chr3:10150139 C3orf24 0.5 6.84 0.35 3.81e-11 Alzheimer's disease; LUSC cis rs2032447 0.530 rs9356996 chr6:26008487 C/A cg16482183 chr6:26056742 HIST1H1C 0.38 5.64 0.3 3.53e-8 Intelligence (multi-trait analysis); LUSC cis rs11105298 0.891 rs11105314 chr12:89924559 C/T cg00757033 chr12:89920650 WDR51B 0.57 10.03 0.48 7.32e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9527 0.590 rs10883820 chr10:104764661 A/C cg05855489 chr10:104503620 C10orf26 -0.52 -8.04 -0.4 1.56e-14 Arsenic metabolism; LUSC cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.35e-16 Menopause (age at onset); LUSC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg04733989 chr22:42467013 NAGA -0.54 -8.57 -0.42 4.01e-16 Schizophrenia; LUSC cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg05283184 chr6:79620031 NA -0.57 -11.82 -0.54 3.53e-27 Intelligence (multi-trait analysis); LUSC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg23625390 chr15:77176239 SCAPER 0.59 9.22 0.45 3.51e-18 Blood metabolite levels; LUSC cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg13852791 chr20:30311386 BCL2L1 0.83 10.31 0.49 7.95e-22 Mean corpuscular hemoglobin; LUSC cis rs868036 0.681 rs4776375 chr15:68085555 G/A cg24579218 chr15:68104479 NA -0.37 -6.58 -0.34 1.85e-10 Restless legs syndrome; LUSC cis rs4147929 0.532 rs4147932 chr19:1064485 C/T cg05372495 chr19:1063624 ABCA7 -0.38 -5.93 -0.31 7.65e-9 Alzheimer's disease (late onset); LUSC cis rs2439831 1.000 rs2256764 chr15:43735763 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.94 10.07 0.48 5.41e-21 Lung cancer in ever smokers; LUSC cis rs7246657 0.943 rs12981532 chr19:37889280 G/A cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 8.87 0.44 4.39e-17 Height; LUSC cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg00310523 chr12:86230176 RASSF9 0.47 8.6 0.43 3.1e-16 Major depressive disorder; LUSC cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg12935359 chr14:103987150 CKB 0.6 9.84 0.47 3.16e-20 Intelligence (multi-trait analysis); LUSC cis rs62380364 0.566 rs1705565 chr5:88048457 C/T cg22951263 chr5:87985283 NA -0.47 -7.72 -0.39 1.39e-13 Intelligence (multi-trait analysis); LUSC cis rs7210086 0.768 rs4485409 chr17:70640381 C/T cg04206342 chr17:70636940 NA -0.34 -5.76 -0.3 1.92e-8 Ulcerative colitis; LUSC cis rs6961069 0.773 rs1761661 chr7:80238041 A/C cg04458919 chr7:80252533 CD36 -0.38 -6.88 -0.35 2.99e-11 Platelet count; LUSC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg23277830 chr1:3704460 LRRC47 0.3 5.8 0.3 1.55e-8 Red cell distribution width; LUSC cis rs11098499 0.754 rs12711071 chr4:120240934 A/G cg24375607 chr4:120327624 NA 0.74 12.02 0.55 6.96e-28 Corneal astigmatism; LUSC cis rs11785400 0.793 rs3735993 chr8:143741170 G/A cg10596483 chr8:143751796 JRK 0.53 7.53 0.38 4.93e-13 Schizophrenia; LUSC cis rs9649213 0.614 rs59120980 chr7:98017730 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.74 -10.42 -0.5 3.49e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs72781680 0.851 rs72796397 chr2:24178211 T/A cg20701182 chr2:24300061 SF3B14 0.58 6.2 0.32 1.71e-9 Lymphocyte counts; LUSC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg06008330 chr7:65541103 ASL -0.4 -6.16 -0.32 2.05e-9 Aortic root size; LUSC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg04455712 chr21:45112962 RRP1B 0.45 8.72 0.43 1.29e-16 Mean corpuscular volume; LUSC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg15790184 chr11:494944 RNH1 0.55 6.2 0.32 1.67e-9 Body mass index; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg08859206 chr1:53392774 SCP2 -0.56 -9.52 -0.46 3.53e-19 Monocyte count; LUSC cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.57 0.38 3.77e-13 Colorectal cancer; LUSC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg04518342 chr5:131593106 PDLIM4 0.35 6.32 0.33 8.19e-10 Blood metabolite levels; LUSC cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.78 -0.35 5.36e-11 Monocyte percentage of white cells; LUSC cis rs472402 0.560 rs2288447 chr5:6626091 C/T cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.4 -5.93 -0.31 7.71e-9 Response to amphetamines; LUSC trans rs35110281 0.667 rs4819287 chr21:45120147 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.57 0.5 1.01e-22 Mean corpuscular volume; LUSC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg17178900 chr1:205818956 PM20D1 0.94 18.64 0.71 1.19e-53 Menarche (age at onset); LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg27284194 chr4:1044797 NA -0.35 -5.68 -0.3 2.93e-8 Obesity-related traits; LUSC cis rs73206853 0.764 rs3026425 chr12:110688168 A/G cg12870014 chr12:110450643 ANKRD13A 0.7 7.64 0.39 2.37e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4363385 0.667 rs454245 chr1:153031979 A/C cg25856811 chr1:152973957 SPRR3 0.34 5.67 0.3 3.14e-8 Inflammatory skin disease; LUSC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg11062466 chr8:58055876 NA 0.59 7.34 0.37 1.65e-12 Developmental language disorder (linguistic errors); LUSC cis rs73129298 0.551 rs16995009 chr20:48602526 T/C cg25655593 chr20:48599521 SNAI1 0.59 6.3 0.33 9.63e-10 Inflammatory skin disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg04204557 chr21:46065774 KRTAP10-11;C21orf29 0.53 6.57 0.34 1.89e-10 Bipolar disorder and schizophrenia; LUSC cis rs2227930 0.510 rs6809448 chr3:142353730 A/G cg16271453 chr3:142027066 XRN1 0.47 8.28 0.41 3.01e-15 Reticulocyte count;Reticulocyte fraction of red cells; LUSC cis rs9815354 0.812 rs73077365 chr3:41851559 T/C cg03022575 chr3:42003672 ULK4 0.85 8.74 0.43 1.16e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6088580 0.524 rs7274854 chr20:33228672 A/C cg07148914 chr20:33460835 GGT7 0.51 8.02 0.4 1.77e-14 Glomerular filtration rate (creatinine); LUSC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg11663144 chr21:46675770 NA -0.38 -6.44 -0.33 4.18e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs477692 0.905 rs508360 chr10:131424969 A/G cg26102564 chr10:131424627 MGMT 0.36 5.68 0.3 2.97e-8 Response to temozolomide; LUSC cis rs1355223 0.557 rs7936076 chr11:34724672 C/T cg11058730 chr11:34937778 PDHX;APIP -0.44 -6.15 -0.32 2.24e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg04450456 chr4:17643702 FAM184B 0.38 6.24 0.32 1.34e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9325144 0.560 rs1843911 chr12:38676585 C/T cg26384229 chr12:38710491 ALG10B -0.67 -10.4 -0.49 3.82e-22 Morning vs. evening chronotype; LUSC cis rs11971779 0.680 rs6962186 chr7:139034806 T/C cg07862535 chr7:139043722 LUC7L2 0.54 6.75 0.35 6.59e-11 Diisocyanate-induced asthma; LUSC cis rs6982240 0.514 rs11778579 chr8:142261621 C/T cg00131261 chr8:142287264 NA -0.36 -6.0 -0.31 5.17e-9 Tonsillectomy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20709868 chr19:12992305 DNASE2 0.47 7.17 0.37 4.95e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs6598955 0.671 rs3924325 chr1:26616320 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.85 -0.44 5.25e-17 Obesity-related traits; LUSC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg21951975 chr1:209979733 IRF6 0.57 8.45 0.42 9.06e-16 Cleft lip with or without cleft palate; LUSC trans rs561341 1.000 rs15654 chr17:30326360 A/C cg27661571 chr11:113659931 NA -0.69 -7.92 -0.4 3.66e-14 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.87 -0.35 3.2e-11 Lung cancer; LUSC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg11871910 chr12:69753446 YEATS4 0.91 16.98 0.68 4.65e-47 Cerebrospinal fluid biomarker levels; LUSC trans rs4252134 0.764 rs62436704 chr6:161199736 C/T cg15416064 chr12:49209402 NA -0.43 -5.96 -0.31 6.39e-9 Giant cell arteritis; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.28 0.56 7.31e-29 Prudent dietary pattern; LUSC trans rs7746199 0.736 rs17693963 chr6:27710165 A/C cg01620082 chr3:125678407 NA -0.76 -7.37 -0.37 1.34e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg00149659 chr3:10157352 C3orf10 0.89 12.11 0.55 3.04e-28 Alzheimer's disease; LUSC cis rs9486715 1.000 rs2273621 chr6:97058553 A/G cg06623918 chr6:96969491 KIAA0776 -0.87 -15.27 -0.64 2.67e-40 Headache; LUSC cis rs9517313 0.615 rs4772079 chr13:99090837 C/G cg20487152 chr13:99095054 FARP1 -0.46 -8.87 -0.44 4.39e-17 Neuroticism; LUSC cis rs2404602 0.647 rs118129828 chr15:77015200 T/C cg23625390 chr15:77176239 SCAPER -0.66 -10.12 -0.48 3.62e-21 Blood metabolite levels; LUSC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg09267113 chr7:98030324 BAIAP2L1 0.39 5.96 0.31 6.32e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11252926 0.603 rs11252670 chr10:529152 A/G cg18196295 chr10:418757 DIP2C -0.37 -5.86 -0.31 1.09e-8 Psychosis in Alzheimer's disease; LUSC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg24250549 chr1:154909240 PMVK 0.64 10.36 0.49 5.26e-22 Prostate cancer; LUSC cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg13010199 chr12:38710504 ALG10B 0.65 9.93 0.48 1.57e-20 Bladder cancer; LUSC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7719624 0.756 rs13188659 chr5:135396468 T/A cg12897067 chr5:135418308 NA 0.4 5.7 0.3 2.63e-8 Response to cytidine analogues (gemcitabine); LUSC cis rs61931739 0.500 rs11053199 chr12:34450534 C/T cg06521331 chr12:34319734 NA 0.43 7.06 0.36 9.56e-12 Morning vs. evening chronotype; LUSC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg16624210 chr5:671434 TPPP 0.5 6.47 0.33 3.58e-10 Obesity-related traits; LUSC cis rs240768 1.000 rs72949504 chr6:100969648 G/C cg12253828 chr6:101329408 ASCC3 0.93 6.4 0.33 5.13e-10 Economic and political preferences (immigration/crime); LUSC cis rs6754311 0.550 rs1438307 chr2:136499166 A/C cg07169764 chr2:136633963 MCM6 0.58 7.67 0.39 1.87e-13 Mosquito bite size; LUSC cis rs1858037 0.867 rs9789444 chr2:65569227 T/C cg08085232 chr2:65598271 SPRED2 -0.4 -5.97 -0.31 6.2e-9 Rheumatoid arthritis; LUSC trans rs61931739 1.000 rs11052989 chr12:34057614 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.99 -0.31 5.35e-9 Morning vs. evening chronotype; LUSC cis rs9303401 0.704 rs7359501 chr17:56641200 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.52 8.2 0.41 5.37e-15 Cognitive test performance; LUSC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.77 -9.8 -0.47 4.27e-20 Gut microbiome composition (summer); LUSC cis rs67696533 0.620 rs911529 chr20:31146939 A/G cg13636640 chr20:31349939 DNMT3B 0.48 6.6 0.34 1.62e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs662064 0.852 rs2056417 chr1:10581658 G/A cg20482658 chr1:10539492 PEX14 0.31 6.22 0.32 1.52e-9 Asthma; LUSC cis rs1577917 0.666 rs6454471 chr6:86214456 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 10.57 0.5 9.82e-23 Response to antipsychotic treatment; LUSC cis rs6964587 0.773 rs12536421 chr7:92008220 A/G cg17063962 chr7:91808500 NA 0.55 7.98 0.4 2.31e-14 Breast cancer; LUSC cis rs9467773 0.620 rs2504571 chr6:26643435 C/T cg05738196 chr6:26577821 NA 0.77 14.7 0.63 4.65e-38 Intelligence (multi-trait analysis); LUSC cis rs7824557 0.585 rs2572385 chr8:11208903 G/A cg27411982 chr8:10470053 RP1L1 0.4 5.97 0.31 6.17e-9 Retinal vascular caliber; LUSC cis rs7917772 0.582 rs7091252 chr10:104328859 G/T cg22532475 chr10:104410764 TRIM8 -0.25 -6.03 -0.31 4.33e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7760535 0.735 rs240974 chr6:111649316 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.77 -0.35 5.94e-11 Metabolic traits; LUSC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.8 -0.6 1.42e-34 Intelligence (multi-trait analysis); LUSC cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg12011299 chr4:100065546 ADH4 0.7 10.4 0.49 3.93e-22 Smoking initiation; LUSC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg20821713 chr7:1055600 C7orf50 -0.48 -6.54 -0.34 2.34e-10 Bronchopulmonary dysplasia; LUSC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.09 -0.36 8.12e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC cis rs34375054 0.525 rs1080910 chr12:125608492 T/C cg00522288 chr12:125625016 AACS -0.31 -5.97 -0.31 5.93e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg00310523 chr12:86230176 RASSF9 0.5 9.44 0.46 6.58e-19 Major depressive disorder; LUSC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg23887609 chr12:130822674 PIWIL1 0.49 7.33 0.37 1.78e-12 Menopause (age at onset); LUSC cis rs1670533 1.000 rs34956924 chr4:1047270 T/C cg27284194 chr4:1044797 NA 0.58 7.84 0.39 6.31e-14 Recombination rate (females); LUSC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg18681998 chr4:17616180 MED28 0.85 15.67 0.65 6.85e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2204008 0.537 rs11170128 chr12:38006632 G/A cg26384229 chr12:38710491 ALG10B 0.91 15.13 0.64 9.11e-40 Bladder cancer; LUSC cis rs262150 0.522 rs2527182 chr7:158813812 A/G cg04111992 chr7:158790115 NA -0.44 -6.99 -0.36 1.46e-11 Facial morphology (factor 20); LUSC trans rs62103177 0.535 rs34299914 chr18:77949236 C/A cg05926928 chr17:57297772 GDPD1 0.86 9.05 0.44 1.24e-17 Opioid sensitivity; LUSC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg06108461 chr20:60628389 TAF4 -0.76 -12.78 -0.57 1.02e-30 Body mass index; LUSC cis rs2404602 0.692 rs55864032 chr15:77122548 A/G cg26408565 chr15:76604113 ETFA -0.49 -7.74 -0.39 1.19e-13 Blood metabolite levels; LUSC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg13393036 chr8:95962371 TP53INP1 -0.37 -7.65 -0.39 2.19e-13 Type 2 diabetes; LUSC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg15448220 chr1:150897856 SETDB1 0.38 5.7 0.3 2.58e-8 Tonsillectomy; LUSC cis rs7267979 1.000 rs6050630 chr20:25430745 A/G cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05499262 chr2:222437089 EPHA4 -0.41 -6.12 -0.32 2.65e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg03354898 chr7:1950403 MAD1L1 -0.35 -6.62 -0.34 1.42e-10 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.61 0.34 1.5e-10 Lung cancer; LUSC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg08270630 chr22:50330655 NA -0.43 -6.58 -0.34 1.79e-10 Schizophrenia; LUSC cis rs6496044 0.568 rs7176291 chr15:86067398 T/C cg13263323 chr15:86062960 AKAP13 -0.39 -6.39 -0.33 5.66e-10 Interstitial lung disease; LUSC cis rs11250097 0.549 rs11778177 chr8:11310362 C/T cg21775007 chr8:11205619 TDH -0.56 -7.53 -0.38 4.65e-13 Neuroticism; LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg21782813 chr7:2030301 MAD1L1 0.45 7.47 0.38 7.1e-13 Bipolar disorder and schizophrenia; LUSC cis rs950776 0.518 rs12910978 chr15:78810017 A/G cg06917634 chr15:78832804 PSMA4 0.82 14.69 0.63 4.94e-38 Sudden cardiac arrest; LUSC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg22963979 chr7:1858916 MAD1L1 -0.56 -8.83 -0.43 6.21e-17 Bipolar disorder and schizophrenia; LUSC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -7.06 -0.36 9.47e-12 Total body bone mineral density; LUSC cis rs12956009 0.583 rs4331415 chr18:44885048 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.06 0.31 3.6e-9 Educational attainment (years of education); LUSC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg26597838 chr10:835615 NA 0.79 9.79 0.47 4.53e-20 Eosinophil percentage of granulocytes; LUSC cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg11266682 chr4:10021025 SLC2A9 0.5 9.25 0.45 2.66e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg03929089 chr4:120376271 NA -1.04 -20.3 -0.74 2.97e-60 Height; LUSC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg08219700 chr8:58056026 NA 0.51 6.08 0.32 3.25e-9 Developmental language disorder (linguistic errors); LUSC cis rs861020 0.771 rs674804 chr1:210014603 C/G cg09163369 chr1:210001066 C1orf107 0.58 6.87 0.35 3.15e-11 Orofacial clefts; LUSC cis rs10949662 1.000 rs11765189 chr7:157535977 A/G cg11757124 chr7:157526947 PTPRN2 -0.42 -6.25 -0.32 1.27e-9 Intelligence (multi-trait analysis); LUSC cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg03517284 chr6:25882590 NA -0.52 -9.87 -0.48 2.47e-20 Blood metabolite levels; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19131103 chr20:62205648 PRIC285 0.7 6.16 0.32 2.05e-9 Cognitive performance; LUSC cis rs34779708 0.966 rs34776628 chr10:35426324 G/A cg03585969 chr10:35415529 CREM 0.6 8.97 0.44 2.11e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs992157 0.775 rs7559428 chr2:219150238 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.03 -0.36 1.17e-11 Colorectal cancer; LUSC cis rs5758511 0.680 rs5758651 chr22:42609148 T/C cg00645731 chr22:42541494 CYP2D7P1 0.58 10.04 0.48 6.66e-21 Birth weight; LUSC cis rs11098499 0.866 rs3756156 chr4:120524841 G/A cg09307838 chr4:120376055 NA 0.69 10.21 0.49 1.76e-21 Corneal astigmatism; LUSC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.1 0.68 1.61e-47 Gut microbiome composition (summer); LUSC cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg24642439 chr20:33292090 TP53INP2 0.49 7.34 0.37 1.62e-12 Glomerular filtration rate (creatinine); LUSC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg13206674 chr6:150067644 NUP43 0.55 8.65 0.43 2.21e-16 Lung cancer; LUSC cis rs977987 0.751 rs56004344 chr16:75474189 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.11 -0.36 6.95e-12 Dupuytren's disease; LUSC cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg08684580 chr7:98029266 BAIAP2L1 0.35 5.7 0.3 2.61e-8 Breast cancer; LUSC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg12463550 chr7:65579703 CRCP 0.42 6.04 0.31 4.16e-9 Aortic root size; LUSC cis rs10744422 1.000 rs7138398 chr12:123341833 G/C cg25930673 chr12:123319894 HIP1R -0.67 -6.83 -0.35 4.15e-11 Schizophrenia; LUSC cis rs7909074 1.000 rs4948925 chr10:45392455 C/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.59 -0.43 3.28e-16 Mean corpuscular volume; LUSC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg04369109 chr6:150039330 LATS1 -0.57 -8.5 -0.42 6.6e-16 Lung cancer; LUSC cis rs12220238 1.000 rs8255 chr10:75879750 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 7.78 0.39 9.02e-14 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg00677455 chr12:58241039 CTDSP2 0.59 8.39 0.42 1.35e-15 Multiple sclerosis; LUSC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg03526776 chr6:41159608 TREML2 0.33 6.19 0.32 1.74e-9 Alzheimer's disease (late onset); LUSC cis rs11264799 0.626 rs12726950 chr1:157575676 A/T cg18268488 chr1:157545234 FCRL4 0.36 6.44 0.33 4.18e-10 IgA nephropathy; LUSC cis rs899997 0.862 rs8032552 chr15:78971136 T/C cg04896959 chr15:78267971 NA -0.43 -8.5 -0.42 6.44e-16 Coronary artery disease or large artery stroke; LUSC cis rs7799006 0.606 rs4721527 chr7:2306655 G/A cg08027265 chr7:2291960 NA -0.62 -11.02 -0.52 2.78e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg00677455 chr12:58241039 CTDSP2 0.5 7.49 0.38 6.04e-13 Intelligence (multi-trait analysis); LUSC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg09021430 chr5:549028 NA -0.57 -7.7 -0.39 1.61e-13 Obesity-related traits; LUSC cis rs4604732 0.631 rs10925044 chr1:247627071 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs6066835 1.000 rs6066833 chr20:47354494 G/C cg18078177 chr20:47281410 PREX1 0.71 6.21 0.32 1.61e-9 Multiple myeloma; LUSC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg25036284 chr2:26402008 FAM59B -0.67 -9.69 -0.47 1.02e-19 Gut microbiome composition (summer); LUSC cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg15155738 chr12:121454335 C12orf43 0.41 5.68 0.3 2.92e-8 N-glycan levels; LUSC cis rs6582630 0.559 rs12318620 chr12:38522340 T/C cg26384229 chr12:38710491 ALG10B -0.57 -8.69 -0.43 1.61e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg00071950 chr4:10020882 SLC2A9 -0.49 -8.15 -0.41 7.43e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs950027 0.620 rs2486274 chr15:45666228 G/T cg21132104 chr15:45694354 SPATA5L1 0.4 5.94 0.31 7.32e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg05973401 chr12:123451056 ABCB9 0.52 6.42 0.33 4.78e-10 Neutrophil percentage of white cells; LUSC cis rs1403694 0.515 rs1648697 chr3:186449194 A/G cg12454167 chr3:186435060 KNG1 0.28 7.6 0.38 2.98e-13 Blood protein levels; LUSC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs10851478 0.872 rs7172906 chr15:49922775 C/G cg23074453 chr15:44487924 FRMD5 -0.33 -6.1 -0.32 2.9e-9 Oral cavity cancer; LUSC cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg21535247 chr6:8435926 SLC35B3 0.56 8.55 0.42 4.56e-16 Motion sickness; LUSC cis rs9807989 0.801 rs10173193 chr2:102975050 G/A cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg19748678 chr4:122722346 EXOSC9 0.61 9.21 0.45 3.74e-18 Type 2 diabetes; LUSC cis rs16854884 0.802 rs6783329 chr3:143798454 T/G cg06585982 chr3:143692056 C3orf58 0.47 6.98 0.36 1.63e-11 Economic and political preferences (feminism/equality); LUSC cis rs9611519 0.929 rs4820423 chr22:41430338 A/T cg03806693 chr22:41940476 POLR3H -0.5 -6.92 -0.35 2.35e-11 Neuroticism; LUSC cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg06064525 chr11:970664 AP2A2 -0.49 -10.81 -0.51 1.48e-23 Alzheimer's disease (late onset); LUSC cis rs2486288 0.554 rs1719235 chr15:45576108 A/G cg09092052 chr15:45571596 NA 0.45 6.13 0.32 2.51e-9 Glomerular filtration rate; LUSC cis rs6500395 0.775 rs7198145 chr16:48666500 A/C cg04672837 chr16:48644449 N4BP1 0.45 6.72 0.35 7.95e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg23711669 chr6:146136114 FBXO30 0.78 12.86 0.58 4.98e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs17092148 1.000 rs62211612 chr20:33386156 C/T cg16810054 chr20:33298113 TP53INP2 0.43 6.81 0.35 4.68e-11 Neuroticism; LUSC trans rs1325195 0.520 rs410589 chr1:179232077 A/G cg11624085 chr17:8464688 MYH10 0.45 6.89 0.35 2.85e-11 IgE grass sensitization; LUSC cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg17845761 chr1:175162550 KIAA0040 0.31 5.94 0.31 7.14e-9 Alcohol dependence; LUSC cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.11 0.32 2.81e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs5769707 0.681 rs2319346 chr22:50029640 A/G cg20744362 chr22:50050164 C22orf34 0.37 6.87 0.35 3.14e-11 Monocyte count;Monocyte percentage of white cells; LUSC trans rs7824557 0.815 rs2572430 chr8:11105304 G/T cg15556689 chr8:8085844 FLJ10661 0.48 6.91 0.35 2.46e-11 Retinal vascular caliber; LUSC trans rs9693857 0.553 rs10100760 chr8:9370559 C/T cg21775007 chr8:11205619 TDH -0.43 -6.34 -0.33 7.27e-10 Systolic blood pressure; LUSC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg24642844 chr7:1081250 C7orf50 -0.72 -10.13 -0.48 3.32e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg11764359 chr7:65958608 NA 0.52 6.63 0.34 1.35e-10 Aortic root size; LUSC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg23630131 chr7:65973040 NA -0.21 -5.9 -0.31 8.71e-9 Aortic root size; LUSC cis rs9300255 0.544 rs1716174 chr12:123660717 T/C cg00376283 chr12:123451042 ABCB9 0.76 8.36 0.42 1.66e-15 Neutrophil percentage of white cells; LUSC cis rs1707322 0.638 rs1707302 chr1:46600917 A/G cg06784218 chr1:46089804 CCDC17 -0.36 -6.66 -0.34 1.1e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7267979 0.966 rs2387885 chr20:25415224 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.57 -0.69 2.11e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4363385 0.776 rs3170863 chr1:152944594 C/T cg07796016 chr1:152779584 LCE1C -0.45 -6.42 -0.33 4.6e-10 Inflammatory skin disease; LUSC cis rs425277 0.606 rs3128339 chr1:2046938 G/T cg24578937 chr1:2090814 PRKCZ -0.43 -9.4 -0.46 8.93e-19 Height; LUSC cis rs9436747 0.618 rs1171266 chr1:66003824 T/C cg14976592 chr1:65886160 LEPROT;LEPR -0.43 -5.74 -0.3 2.08e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.62 -8.05 -0.4 1.49e-14 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7712401 0.755 rs1870560 chr5:122111210 G/C cg19077854 chr5:122220652 SNX24 0.35 7.79 0.39 8.8e-14 Mean platelet volume; LUSC cis rs7954584 0.626 rs12809676 chr12:122442381 C/A cg21171335 chr12:122356390 WDR66 0.58 8.51 0.42 5.88e-16 Mean corpuscular volume; LUSC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg19318889 chr4:1322082 MAEA 0.56 9.5 0.46 4.31e-19 Obesity-related traits; LUSC cis rs5769707 0.681 rs2071902 chr22:50034538 G/C cg05373962 chr22:49881684 NA -0.4 -8.66 -0.43 2.03e-16 Monocyte count;Monocyte percentage of white cells; LUSC cis rs939574 1.000 rs9989854 chr2:220086280 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.92 -8.42 -0.42 1.09e-15 Platelet distribution width; LUSC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Parkinson's disease; LUSC cis rs2841277 0.676 rs10438246 chr14:105410183 T/C cg19901468 chr14:105411992 AHNAK2 -0.71 -12.38 -0.56 3.24e-29 Rheumatoid arthritis; LUSC cis rs13315871 1.000 rs13096020 chr3:58367771 G/A cg12435725 chr3:58293450 RPP14 -0.72 -7.16 -0.36 5.13e-12 Cholesterol, total; LUSC cis rs259282 0.538 rs12151311 chr19:33112707 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.74 10.76 0.51 2.24e-23 Schizophrenia; LUSC cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg19875535 chr5:140030758 IK -0.55 -9.07 -0.44 1.04e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs977987 0.806 rs11862582 chr16:75431295 T/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.7 -0.34 9e-11 Dupuytren's disease; LUSC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg22638593 chr5:131593259 PDLIM4 -0.46 -6.84 -0.35 3.76e-11 Acylcarnitine levels; LUSC cis rs950027 1.000 rs950027 chr15:45801035 C/T cg04036182 chr15:45458818 NA -0.35 -5.97 -0.31 6.02e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.67 11.73 0.54 7.53e-27 Menarche (age at onset); LUSC trans rs13011075 0.919 rs2241947 chr2:68615395 C/T cg14221825 chr19:46271408 SIX5 0.45 6.34 0.33 7.62e-10 Mean corpuscular volume; LUSC cis rs2073300 0.609 rs77673953 chr20:23398794 G/C cg12062639 chr20:23401060 NAPB 0.97 8.32 0.41 2.25e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9326248 0.581 rs10502222 chr11:116833730 C/T cg01368799 chr11:117014884 PAFAH1B2 0.6 9.19 0.45 4.26e-18 Blood protein levels; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg13685833 chr1:53393034 SCP2 0.43 6.38 0.33 5.91e-10 Monocyte count; LUSC cis rs11122272 0.735 rs2808611 chr1:231548480 A/G cg10503236 chr1:231470652 EXOC8 0.35 5.65 0.3 3.46e-8 Hemoglobin concentration; LUSC cis rs17270561 0.609 rs4712965 chr6:25742022 G/T cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs10416265 0.503 rs1981818 chr19:33615122 C/T cg27124370 chr19:33622961 WDR88 -0.51 -7.06 -0.36 9.63e-12 Bone properties (heel); LUSC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg01802117 chr1:53393560 SCP2 0.38 6.17 0.32 1.97e-9 Monocyte count; LUSC cis rs2273669 0.667 rs10457187 chr6:109336051 G/A cg05315195 chr6:109294784 ARMC2 -0.53 -5.89 -0.31 9.28e-9 Prostate cancer; LUSC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg11062466 chr8:58055876 NA 0.47 6.28 0.32 1.07e-9 Developmental language disorder (linguistic errors); LUSC cis rs909002 0.800 rs11589306 chr1:32082822 C/G cg01639898 chr1:32083012 HCRTR1 0.32 7.69 0.39 1.65e-13 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg07701084 chr6:150067640 NUP43 0.5 7.52 0.38 5.19e-13 Lung cancer; LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.69 10.63 0.5 6.38e-23 Lymphocyte counts; LUSC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs807669 0.903 rs807666 chr22:19160549 C/T cg02655711 chr22:19163373 SLC25A1 0.89 17.98 0.7 4.87e-51 Metabolite levels; LUSC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg26335602 chr6:28129616 ZNF389 0.45 5.99 0.31 5.47e-9 Depression; LUSC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg16606324 chr3:10149918 C3orf24 0.63 8.86 0.44 4.76e-17 Alzheimer's disease; LUSC cis rs9581857 0.547 rs17753121 chr13:28052613 T/C cg22138327 chr13:27999177 GTF3A 0.77 8.21 0.41 4.96e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg26335602 chr6:28129616 ZNF389 0.44 5.83 0.3 1.31e-8 Depression; LUSC cis rs2952156 1.000 rs4252627 chr17:37868715 C/T cg20243544 chr17:37824526 PNMT 0.49 6.94 0.36 2.01e-11 Asthma; LUSC trans rs4843747 0.636 rs11864872 chr16:88105966 A/G cg26811252 chr16:29126840 RRN3P2 0.57 9.15 0.45 5.58e-18 Menopause (age at onset); LUSC cis rs12908161 1.000 rs11632465 chr15:85282045 A/T cg17507749 chr15:85114479 UBE2QP1 0.54 6.74 0.35 7.17e-11 Schizophrenia; LUSC cis rs1577917 1.000 rs1337850 chr6:86729103 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.08 -0.36 8.81e-12 Response to antipsychotic treatment; LUSC cis rs11098499 0.954 rs6838814 chr4:120392443 G/A cg09307838 chr4:120376055 NA 0.78 11.14 0.52 1.05e-24 Corneal astigmatism; LUSC cis rs7011049 1.000 rs72640857 chr8:53839067 T/A cg26025543 chr8:53854495 NA 0.52 6.3 0.33 9.5e-10 Systolic blood pressure; LUSC cis rs295140 1.000 rs12618057 chr2:201171355 T/C cg04283868 chr2:201171347 SPATS2L 0.43 6.57 0.34 1.88e-10 QT interval; LUSC cis rs2730245 1.000 rs2657345 chr7:158744169 T/C cg24397884 chr7:158709396 WDR60 -0.77 -12.12 -0.55 2.77e-28 Height; LUSC cis rs983392 0.776 rs2278867 chr11:59943109 A/T cg20284999 chr11:59952153 MS4A6A -0.38 -6.28 -0.32 1.07e-9 Alzheimer's disease (late onset); LUSC cis rs6429082 0.818 rs704706 chr1:235614378 G/A cg26050004 chr1:235667680 B3GALNT2 0.63 8.57 0.42 3.88e-16 Adiposity; LUSC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg13393036 chr8:95962371 TP53INP1 -0.48 -10.43 -0.5 3.08e-22 Type 2 diabetes; LUSC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 0.58 9.4 0.46 9.25e-19 Vitiligo; LUSC cis rs6570726 0.967 rs9403707 chr6:145800010 A/G cg05347473 chr6:146136440 FBXO30 0.39 6.55 0.34 2.19e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg01879757 chr17:41196368 BRCA1 -0.49 -7.99 -0.4 2.21e-14 Menopause (age at onset); LUSC cis rs9393777 0.623 rs34313099 chr6:26489607 C/T cg12826209 chr6:26865740 GUSBL1 0.68 7.57 0.38 3.63e-13 Intelligence (multi-trait analysis); LUSC cis rs1371867 0.846 rs959022 chr8:101295992 T/A cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.54e-15 Atrioventricular conduction; LUSC cis rs9457247 1.000 rs239935 chr6:167411788 G/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.55 -0.34 2.15e-10 Crohn's disease; LUSC cis rs12973672 1.000 rs10405246 chr19:35768949 A/G cg12095397 chr19:35769544 USF2 0.44 6.91 0.35 2.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6138458 0.961 rs11700073 chr20:24975215 C/G cg06937882 chr20:24974362 C20orf3 -0.44 -7.66 -0.39 1.97e-13 Blood protein levels; LUSC cis rs7772486 0.776 rs2265467 chr6:146218339 T/A cg23711669 chr6:146136114 FBXO30 0.81 14.85 0.63 1.16e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.6 0.57 4.77e-30 Motion sickness; LUSC cis rs1003719 0.751 rs55992706 chr21:38542749 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.67 -10.46 -0.5 2.51e-22 Eye color traits; LUSC cis rs7726839 0.794 rs10053310 chr5:595661 C/G cg16447950 chr5:562315 NA -0.48 -6.55 -0.34 2.23e-10 Obesity-related traits; LUSC cis rs8072100 0.688 rs7221224 chr17:45419061 T/G cg25173405 chr17:45401733 C17orf57 0.41 5.91 0.31 8.48e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg22166914 chr1:53195759 ZYG11B -0.61 -10.16 -0.49 2.54e-21 Monocyte count; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg25103766 chr1:120838445 FAM72B -0.46 -6.1 -0.32 2.95e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg08470875 chr2:26401718 FAM59B 0.66 8.3 0.41 2.55e-15 Gut microbiome composition (summer); LUSC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg07701084 chr6:150067640 NUP43 0.56 8.37 0.42 1.65e-15 Lung cancer; LUSC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg18230493 chr5:56204884 C5orf35 -0.58 -9.22 -0.45 3.55e-18 Coronary artery disease; LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg25036284 chr2:26402008 FAM59B 0.77 10.92 0.51 5.98e-24 Gut microbiome composition (summer); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22345911 chr17:80231263 CSNK1D -0.39 -7.4 -0.38 1.1e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs61931739 0.500 rs34080094 chr12:34547952 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg13397359 chr6:42928475 GNMT 0.44 5.72 0.3 2.4e-8 Blood protein levels; LUSC cis rs11758351 0.660 rs77130538 chr6:26210723 T/C cg01420254 chr6:26195488 NA 0.65 6.99 0.36 1.54e-11 Gout;Renal underexcretion gout; LUSC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg07424592 chr7:64974309 NA 0.66 5.82 0.3 1.38e-8 Diabetic kidney disease; LUSC cis rs67460515 0.529 rs11712713 chr3:160852471 A/G cg03342759 chr3:160939853 NMD3 -0.43 -6.29 -0.33 9.75e-10 Parkinson's disease; LUSC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg01420254 chr6:26195488 NA 0.64 6.99 0.36 1.53e-11 Gout;Renal underexcretion gout; LUSC cis rs5769707 0.656 rs135875 chr22:50012419 T/G cg20744362 chr22:50050164 C22orf34 0.39 7.13 0.36 6.39e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11758351 0.660 rs75156165 chr6:26235699 C/A cg23601095 chr6:26197514 HIST1H3D 0.69 7.46 0.38 7.54e-13 Gout;Renal underexcretion gout; LUSC cis rs11122272 0.735 rs2790890 chr1:231514567 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.85 -0.47 2.99e-20 Hemoglobin concentration; LUSC cis rs6696846 0.791 rs11240352 chr1:205051711 C/G cg03948781 chr1:205179583 DSTYK -0.3 -5.82 -0.3 1.4e-8 Red blood cell count; LUSC cis rs7605827 0.930 rs4140713 chr2:15536128 C/T cg19274914 chr2:15703543 NA 0.46 9.03 0.44 1.45e-17 Educational attainment (years of education); LUSC trans rs2197308 0.692 rs1904964 chr12:37933241 T/A cg06521331 chr12:34319734 NA -0.4 -6.21 -0.32 1.54e-9 Morning vs. evening chronotype; LUSC cis rs6546550 0.935 rs2872075 chr2:70068635 G/T cg02498382 chr2:70120550 SNRNP27 -0.27 -6.38 -0.33 5.95e-10 Prevalent atrial fibrillation; LUSC cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg18681998 chr4:17616180 MED28 0.81 13.56 0.6 1.11e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg03709012 chr19:19516395 GATAD2A 0.73 10.87 0.51 9.31e-24 Tonsillectomy; LUSC cis rs3126085 1.000 rs11485508 chr1:152253167 T/G cg26876637 chr1:152193138 HRNR 0.46 6.38 0.33 6.03e-10 Atopic dermatitis; LUSC cis rs983392 0.679 rs603648 chr11:60012673 A/T cg02771260 chr11:59836817 MS4A3 0.37 6.15 0.32 2.16e-9 Alzheimer's disease (late onset); LUSC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs8062405 0.824 rs4788085 chr16:28535003 A/G cg16576597 chr16:28551801 NUPR1 0.28 5.65 0.3 3.52e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs11992162 0.933 rs10108075 chr8:11832079 A/G cg21775007 chr8:11205619 TDH 0.54 7.51 0.38 5.35e-13 Monocyte count; LUSC cis rs57502260 0.680 rs55654976 chr11:68393541 C/T cg20283391 chr11:68216788 NA -0.65 -6.03 -0.31 4.36e-9 Total body bone mineral density (age 45-60); LUSC cis rs12928939 0.815 rs12448022 chr16:71724369 T/C cg08717414 chr16:71523259 ZNF19 -0.41 -5.78 -0.3 1.71e-8 Post bronchodilator FEV1; LUSC cis rs12893668 0.703 rs7148456 chr14:104028270 C/T cg08213375 chr14:104286397 PPP1R13B -0.35 -5.79 -0.3 1.63e-8 Reticulocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23430742 chr12:120907701 DYNLL1;SFRS9 -0.43 -6.4 -0.33 5.41e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs754466 0.580 rs10824577 chr10:79577408 G/C cg17075019 chr10:79541650 NA -0.76 -12.15 -0.55 2.21e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22481344 chr6:144607497 NA -0.39 -6.1 -0.32 2.88e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs8073060 0.586 rs225291 chr17:33927126 A/G cg19694781 chr19:47549865 TMEM160 -1.05 -16.41 -0.67 8.79e-45 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs34779708 0.931 rs4934700 chr10:35310842 A/G cg03585969 chr10:35415529 CREM 0.64 9.13 0.45 6.76e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10489202 1.000 rs17485889 chr1:168018840 G/T cg24449463 chr1:168025552 DCAF6 -0.56 -7.04 -0.36 1.08e-11 Schizophrenia; LUSC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg07211511 chr3:129823064 LOC729375 -1.24 -20.13 -0.74 1.47e-59 Blood pressure (smoking interaction); LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg23758822 chr17:41437982 NA 1.03 19.23 0.72 5.24e-56 Menopause (age at onset); LUSC cis rs7202877 0.656 rs4887812 chr16:75310052 G/A cg04384234 chr16:75411784 CFDP1 -0.65 -8.65 -0.43 2.26e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs4803468 1.000 rs11670757 chr19:41913431 G/T cg09537434 chr19:41945824 ATP5SL -0.9 -16.03 -0.66 2.7e-43 Height; LUSC cis rs10740039 0.804 rs2028563 chr10:62436897 C/T cg18175470 chr10:62150864 ANK3 0.48 7.26 0.37 2.71e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6087990 0.966 rs1883730 chr20:31337487 T/A cg13636640 chr20:31349939 DNMT3B 1.03 24.07 0.8 5.89e-75 Ulcerative colitis; LUSC cis rs9462027 0.628 rs9296127 chr6:34719628 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.92 -0.31 7.98e-9 Systemic lupus erythematosus; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11403890 chr1:41708077 SCMH1 -0.42 -6.27 -0.32 1.11e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4308124 0.708 rs61358692 chr2:111965159 T/C cg04571233 chr2:111982156 NA -0.51 -6.6 -0.34 1.62e-10 Vitiligo; LUSC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg21782813 chr7:2030301 MAD1L1 0.4 6.61 0.34 1.52e-10 Bipolar disorder and schizophrenia; LUSC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg05425664 chr17:57184151 TRIM37 0.51 7.96 0.4 2.65e-14 Intelligence (multi-trait analysis); LUSC cis rs4631830 0.863 rs10826127 chr10:51530757 G/A cg20129853 chr10:51489980 NA -0.35 -7.0 -0.36 1.41e-11 Prostate-specific antigen levels; LUSC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 11.21 0.52 5.59e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6088580 0.524 rs6088565 chr20:33254986 A/C cg07148914 chr20:33460835 GGT7 -0.56 -8.54 -0.42 4.68e-16 Glomerular filtration rate (creatinine); LUSC cis rs734999 0.588 rs2843401 chr1:2528133 T/C cg18854424 chr1:2615690 NA -0.49 -9.82 -0.47 3.55e-20 Ulcerative colitis; LUSC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg15445000 chr17:37608096 MED1 0.39 6.71 0.34 8.49e-11 Glomerular filtration rate (creatinine); LUSC cis rs713587 0.563 rs10865315 chr2:25100738 C/A cg04586622 chr2:25135609 ADCY3 0.38 7.71 0.39 1.45e-13 Body mass index in non-asthmatics; LUSC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg07395648 chr5:131743802 NA 0.38 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC cis rs8078723 1.000 rs7214085 chr17:38169095 T/C cg17467752 chr17:38218738 THRA 0.77 12.44 0.56 1.94e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg21285383 chr16:89894308 SPIRE2 0.34 7.29 0.37 2.24e-12 Vitiligo; LUSC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 9.78 0.47 4.85e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6546537 0.840 rs34743816 chr2:69813345 A/C cg10773587 chr2:69614142 GFPT1 -0.52 -8.12 -0.41 9.36e-15 Serum thyroid-stimulating hormone levels; LUSC cis rs4285028 0.699 rs2689290 chr3:121585146 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.75 -10.59 -0.5 8.94e-23 Multiple sclerosis; LUSC cis rs7215564 0.908 rs35646299 chr17:78653506 T/G cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg22508957 chr16:3507546 NAT15 -0.38 -6.14 -0.32 2.41e-9 Body mass index (adult); LUSC cis rs55728055 0.661 rs1018488 chr22:31992376 A/G cg01338084 chr22:32026380 PISD 1.0 7.04 0.36 1.08e-11 Age-related hearing impairment; LUSC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03934478 chr11:495069 RNH1 0.91 10.47 0.5 2.32e-22 Body mass index; LUSC cis rs11168618 0.626 rs11514105 chr12:48820934 G/C cg24011408 chr12:48396354 COL2A1 0.41 6.5 0.34 2.85e-10 Adiponectin levels; LUSC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg04369109 chr6:150039330 LATS1 -0.55 -8.11 -0.41 9.41e-15 Lung cancer; LUSC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg05373962 chr22:49881684 NA -0.41 -10.1 -0.48 4.19e-21 Monocyte count;Monocyte percentage of white cells; LUSC cis rs925550 0.592 rs1026157 chr4:123623893 G/T cg10495464 chr4:123653540 BBS12;LOC729338 0.52 6.89 0.35 2.78e-11 Primary biliary cholangitis; LUSC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg20135002 chr11:47629003 NA -0.48 -7.57 -0.38 3.61e-13 Subjective well-being; LUSC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg22467129 chr15:76604101 ETFA -0.44 -7.05 -0.36 1.06e-11 Blood metabolite levels; LUSC cis rs2732480 0.577 rs2634691 chr12:48708259 G/T cg21466736 chr12:48725269 NA -0.33 -5.74 -0.3 2.16e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs509477 0.718 rs273342 chr18:32604956 G/A cg23791764 chr18:32556832 MAPRE2 0.4 5.79 0.3 1.65e-8 Cerebrospinal fluid AB1-42 levels; LUSC cis rs1008375 1.000 rs12648232 chr4:17612537 C/T cg16339924 chr4:17578868 LAP3 -0.52 -7.51 -0.38 5.41e-13 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.4 -0.38 1.08e-12 Menarche (age at onset); LUSC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.52 6.11 0.32 2.77e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs611744 0.608 rs667742 chr8:109254003 T/C cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 7.89e-10 Dupuytren's disease; LUSC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg18825119 chr6:163149453 PACRG;PARK2 -0.36 -6.42 -0.33 4.7e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.28 0.32 1.08e-9 Tonsillectomy; LUSC cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg16797656 chr11:68205561 LRP5 0.36 6.1 0.32 2.96e-9 Total body bone mineral density; LUSC cis rs708547 0.874 rs781551 chr4:57718406 A/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.58 -7.03 -0.36 1.15e-11 Response to bleomycin (chromatid breaks); LUSC cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg03146154 chr1:46216737 IPP 0.54 8.24 0.41 4e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7191700 1.000 rs7191700 chr16:11406803 C/T cg00044050 chr16:11439710 C16orf75 0.59 8.78 0.43 8.9e-17 Multiple sclerosis; LUSC cis rs9388451 0.559 rs1777210 chr6:126098916 T/G cg05901451 chr6:126070800 HEY2 -0.76 -12.99 -0.58 1.61e-31 Brugada syndrome; LUSC cis rs9925964 0.967 rs12716981 chr16:31118024 C/A cg02466173 chr16:30829666 NA 0.33 6.05 0.31 3.89e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2455601 0.671 rs10840135 chr11:8879794 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -7.7 -0.39 1.58e-13 Schizophrenia; LUSC cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.2 -0.37 3.89e-12 Menarche (age at onset); LUSC cis rs612683 0.602 rs12565245 chr1:101019326 T/G cg09408571 chr1:101003634 GPR88 0.31 5.88 0.31 1.01e-8 Breast cancer; LUSC cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -11.06 -0.52 1.88e-24 Chronic sinus infection; LUSC trans rs6502050 0.764 rs35713597 chr17:80119016 C/G cg07393940 chr7:158741817 NA 0.36 6.49 0.33 3.02e-10 Life satisfaction; LUSC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg17173187 chr15:85201210 NMB 0.37 6.57 0.34 1.96e-10 Schizophrenia; LUSC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg06138931 chr13:21896616 NA 0.4 6.81 0.35 4.65e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC trans rs1997103 0.705 rs56301138 chr7:55396555 G/T cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs568617 0.953 rs658938 chr11:65651830 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.5 -6.03 -0.31 4.42e-9 Crohn's disease; LUSC cis rs112790992 1 rs112790992 chr14:105758217 A/C cg10792982 chr14:105748885 BRF1 0.45 8.08 0.4 1.2e-14 Platelet count; LUSC cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg21609526 chr1:3105151 PRDM16 -0.31 -6.19 -0.32 1.73e-9 Migraine; LUSC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg20243544 chr17:37824526 PNMT 0.52 7.4 0.38 1.12e-12 Asthma; LUSC cis rs11098499 0.691 rs12510133 chr4:120271344 A/C cg24375607 chr4:120327624 NA 0.66 10.52 0.5 1.48e-22 Corneal astigmatism; LUSC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.92e-10 Life satisfaction; LUSC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15249164 chr21:35288186 ATP5O -0.52 -6.03 -0.31 4.26e-9 Bipolar disorder and schizophrenia; LUSC cis rs6076065 0.723 rs743023 chr20:23400852 T/C cg11657817 chr20:23433608 CST11 0.42 7.45 0.38 7.98e-13 Facial morphology (factor 15, philtrum width); LUSC cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg14500267 chr11:67383377 NA -0.32 -5.81 -0.3 1.42e-8 Mean corpuscular volume; LUSC cis rs72480748 0.509 rs3865457 chr19:41398969 C/T cg14550611 chr19:41354682 CYP2A6 0.4 6.84 0.35 3.88e-11 Post bronchodilator FEV1;Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio); LUSC cis rs7241530 0.636 rs66549018 chr18:75904099 C/A cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg20203395 chr5:56204925 C5orf35 -0.58 -8.14 -0.41 7.93e-15 Initial pursuit acceleration; LUSC cis rs10779751 0.734 rs2748877 chr1:11129437 T/C cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg24531977 chr5:56204891 C5orf35 -0.67 -9.76 -0.47 5.87e-20 Coronary artery disease; LUSC cis rs12594515 1.000 rs58368732 chr15:45990531 G/C cg19682013 chr15:45996608 NA 0.38 5.88 0.31 1.02e-8 Waist circumference;Weight; LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.56 7.81 0.39 7.3e-14 Gut microbiome composition (summer); LUSC cis rs2357013 0.752 rs4672085 chr2:53154899 G/A cg07782112 chr2:53107842 NA -0.41 -6.36 -0.33 6.66e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.92 -0.44 3.19e-17 Monocyte count; LUSC cis rs1712517 0.771 rs11191645 chr10:105059308 G/T cg05636881 chr10:105038444 INA 0.39 6.42 0.33 4.73e-10 Migraine; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G ch.8.1736467F chr8:84114645 NA 0.44 6.39 0.33 5.63e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs73206853 0.764 rs7960705 chr12:111084540 G/A cg12870014 chr12:110450643 ANKRD13A 0.7 7.69 0.39 1.68e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs713587 0.967 rs6752378 chr2:25150116 C/A cg04586622 chr2:25135609 ADCY3 0.4 8.37 0.42 1.58e-15 Body mass index in non-asthmatics; LUSC cis rs662064 0.962 rs668805 chr1:10544547 A/G cg20482658 chr1:10539492 PEX14 0.33 7.01 0.36 1.3e-11 Asthma; LUSC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg00745463 chr17:30367425 LRRC37B -0.76 -8.58 -0.43 3.6e-16 Hip circumference adjusted for BMI; LUSC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg06112835 chr11:68658793 MRPL21 0.52 7.81 0.39 7.23e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1371867 0.839 rs1660313 chr8:101332712 G/A cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08693705 chr5:179719171 MAPK9 -0.43 -6.3 -0.33 9.23e-10 Electrocardiographic conduction measures; LUSC cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.95 0.7 6.41e-51 Chronic sinus infection; LUSC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg06221963 chr1:154839813 KCNN3 -0.65 -15.56 -0.65 1.89e-41 Prostate cancer; LUSC cis rs714027 1.000 rs5763821 chr22:30549071 A/C cg11564601 chr22:30592435 NA -0.36 -6.61 -0.34 1.49e-10 Lymphocyte counts; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22507989 chr22:21356069 FLJ39582;THAP7 -0.38 -6.2 -0.32 1.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9527 0.590 rs943039 chr10:104825132 C/T cg05855489 chr10:104503620 C10orf26 0.53 8.01 0.4 1.98e-14 Arsenic metabolism; LUSC cis rs11785400 0.762 rs7007349 chr8:143722673 T/C cg24634471 chr8:143751801 JRK 0.51 7.23 0.37 3.23e-12 Schizophrenia; LUSC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.08 -0.48 4.71e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs368755101 1 rs368755101 chr2:100762215 AG/A cg07810366 chr2:100720526 AFF3 -0.47 -7.87 -0.4 4.93e-14 Plateletcrit;Red blood cell count; LUSC cis rs7945718 0.967 rs12291695 chr11:12795662 A/G cg25843174 chr11:12811716 TEAD1 -0.34 -6.9 -0.35 2.57e-11 Educational attainment (years of education); LUSC trans rs7726839 0.526 rs11960158 chr5:568665 C/T cg25482853 chr8:67687455 SGK3 1.02 16.18 0.66 6.92e-44 Obesity-related traits; LUSC cis rs10489202 1.000 rs66950781 chr1:168018779 C/A cg24449463 chr1:168025552 DCAF6 -0.6 -7.54 -0.38 4.36e-13 Schizophrenia; LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.84 -16.83 -0.68 1.88e-46 Prudent dietary pattern; LUSC cis rs2976388 0.625 rs2257840 chr8:143809193 C/T cg17252645 chr8:143867129 LY6D 0.38 6.59 0.34 1.76e-10 Urinary tract infection frequency; LUSC cis rs1451375 0.617 rs7790758 chr7:50561544 G/A cg18232548 chr7:50535776 DDC -0.54 -7.54 -0.38 4.37e-13 Malaria; LUSC cis rs7089973 0.604 rs11196936 chr10:116588630 C/T cg23260525 chr10:116636907 FAM160B1 0.43 9.21 0.45 3.72e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg08470875 chr2:26401718 FAM59B 0.69 8.92 0.44 3.02e-17 Gut microbiome composition (summer); LUSC cis rs10028773 0.506 rs12374346 chr4:120281705 G/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Educational attainment; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07540722 chr2:70056697 GMCL1 -0.4 -6.09 -0.32 3.05e-9 Electrocardiographic conduction measures; LUSC trans rs72674100 1.000 rs72880598 chr4:97988599 A/G cg09670535 chr1:18959427 PAX7 -0.56 -6.01 -0.31 4.76e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs204247 0.565 rs411094 chr6:13718264 C/A cg07534331 chr6:13574296 SIRT5 0.42 5.72 0.3 2.37e-8 Breast cancer; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg01994308 chr8:57122990 PLAG1;CHCHD7 0.35 6.34 0.33 7.54e-10 Schizophrenia; LUSC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg00149659 chr3:10157352 C3orf10 0.92 12.88 0.58 4.25e-31 Alzheimer's disease; LUSC trans rs12579753 0.879 rs7131927 chr12:82166313 T/C cg07923666 chr12:49932857 KCNH3 -0.5 -6.41 -0.33 5.08e-10 Resting heart rate; LUSC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg23758822 chr17:41437982 NA 1.0 19.61 0.73 1.66e-57 Menopause (age at onset); LUSC cis rs2219968 1.000 rs16939594 chr8:78969920 T/A cg00738934 chr8:78996279 NA 0.34 6.2 0.32 1.62e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4689388 0.926 rs4688987 chr4:6287329 C/T cg00701064 chr4:6280414 WFS1 0.58 14.33 0.62 1.25e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1538970 0.924 rs4660851 chr1:45843810 A/T cg05343316 chr1:45956843 TESK2 0.6 8.49 0.42 7.07e-16 Platelet count; LUSC cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg05340658 chr4:99064831 C4orf37 0.66 10.86 0.51 9.9899999999999993e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg13319975 chr6:146136371 FBXO30 -0.48 -7.11 -0.36 6.89e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg00509249 chr6:109615579 CCDC162 -0.32 -5.87 -0.31 1.03e-8 Reticulocyte fraction of red cells; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg13807970 chr2:145274441 ZEB2 0.43 6.1 0.32 2.9e-9 Mosquito bite size; LUSC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg01238044 chr22:24384105 GSTT1 -0.73 -12.52 -0.57 9.58e-30 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.47 -0.73 5.98e-57 Height; LUSC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg13072238 chr3:49761600 GMPPB -0.36 -5.85 -0.3 1.16e-8 Body mass index; LUSC cis rs35306767 0.714 rs7072554 chr10:1090988 C/T cg26597838 chr10:835615 NA 0.57 7.44 0.38 8.8e-13 Eosinophil percentage of granulocytes; LUSC cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg01028140 chr2:1542097 TPO -0.61 -8.06 -0.4 1.36e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg04267008 chr7:1944627 MAD1L1 -0.5 -7.36 -0.37 1.46e-12 Bipolar disorder and schizophrenia; LUSC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg18225595 chr11:63971243 STIP1 -0.48 -7.75 -0.39 1.1e-13 Platelet count; LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.52 -6.96 -0.36 1.78e-11 Renal function-related traits (BUN); LUSC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg12560992 chr17:57184187 TRIM37 0.84 15.48 0.65 3.82e-41 Intelligence (multi-trait analysis); LUSC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg15445000 chr17:37608096 MED1 0.4 6.77 0.35 5.85e-11 Glomerular filtration rate (creatinine); LUSC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg25566285 chr7:158114605 PTPRN2 0.31 5.85 0.3 1.2e-8 Calcium levels; LUSC cis rs72781680 0.898 rs72788214 chr2:24087621 A/C cg08917208 chr2:24149416 ATAD2B 0.87 9.86 0.47 2.6e-20 Lymphocyte counts; LUSC cis rs7904368 0.707 rs12253979 chr10:16853415 T/C cg23933602 chr10:16859644 RSU1 0.59 6.92 0.35 2.36e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg13390004 chr1:15929781 NA 0.43 7.27 0.37 2.61e-12 Systolic blood pressure; LUSC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg03233332 chr7:66118400 NA -0.43 -6.18 -0.32 1.85e-9 Aortic root size; LUSC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg00800038 chr16:89945340 TCF25 -0.75 -6.64 -0.34 1.26e-10 Skin colour saturation; LUSC cis rs5758659 0.714 rs5758578 chr22:42490292 A/C cg04733989 chr22:42467013 NAGA -0.4 -6.52 -0.34 2.63e-10 Cognitive function; LUSC cis rs34779708 0.931 rs72789687 chr10:35372489 G/A cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg26441486 chr22:50317300 CRELD2 0.48 7.15 0.36 5.66e-12 Schizophrenia; LUSC cis rs12421382 0.659 rs11604254 chr11:109392413 G/A cg11473876 chr11:109292803 C11orf87 0.41 6.58 0.34 1.82e-10 Schizophrenia; LUSC cis rs2806561 1.000 rs2473851 chr1:23489869 A/G cg19743168 chr1:23544995 NA 0.43 9.3 0.45 1.9e-18 Height; LUSC cis rs12928939 0.815 rs34731378 chr16:71745748 C/T cg03805757 chr16:71968109 PKD1L3 -0.39 -5.7 -0.3 2.61e-8 Post bronchodilator FEV1; LUSC cis rs66887589 0.592 rs2175383 chr4:120215836 C/A cg09307838 chr4:120376055 NA 0.53 7.92 0.4 3.59e-14 Diastolic blood pressure; LUSC trans rs45509595 0.749 rs401763 chr6:27782528 T/C cg06606381 chr12:133084897 FBRSL1 -0.74 -7.4 -0.38 1.1e-12 Breast cancer; LUSC cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg17892150 chr10:133769511 PPP2R2D -0.66 -9.42 -0.46 7.42e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs4891159 0.790 rs11150953 chr18:74145491 G/A cg24786174 chr18:74118243 ZNF516 -0.84 -15.61 -0.65 1.18e-41 Longevity; LUSC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg06494592 chr3:125709126 NA -0.51 -6.21 -0.32 1.55e-9 Blood pressure (smoking interaction); LUSC cis rs2404602 0.647 rs907593 chr15:77196953 G/A cg23625390 chr15:77176239 SCAPER -0.66 -9.75 -0.47 6.09e-20 Blood metabolite levels; LUSC cis rs868036 1.000 rs4325504 chr15:68055570 A/G cg05925327 chr15:68127851 NA 0.33 5.88 0.31 9.84e-9 Restless legs syndrome; LUSC cis rs6542838 0.641 rs13005124 chr2:99527680 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -6.43 -0.33 4.45e-10 Fear of minor pain; LUSC cis rs8062405 0.755 rs62034358 chr16:28587597 G/T cg16576597 chr16:28551801 NUPR1 0.34 6.88 0.35 2.97e-11 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs939574 1.000 rs1109866 chr2:220083279 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.94 -8.06 -0.4 1.42e-14 Platelet distribution width; LUSC cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -7.24 -0.37 3.19e-12 Chronic sinus infection; LUSC cis rs1344694 0.566 rs4672790 chr2:216892446 C/T cg12620499 chr2:216877984 MREG 0.69 11.06 0.52 1.91e-24 Alcohol dependence; LUSC cis rs9788721 0.902 rs17486195 chr15:78865197 A/G cg18825076 chr15:78729989 IREB2 -0.5 -7.86 -0.39 5.49e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs427941 0.632 rs382228 chr7:101786064 A/C cg06246474 chr7:101738831 CUX1 0.38 6.24 0.32 1.32e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs7180079 0.620 rs12903003 chr15:64711986 A/G cg08069370 chr15:64387884 SNX1 0.51 5.64 0.3 3.55e-8 Monocyte count; LUSC cis rs894734 0.567 rs7138907 chr12:54324576 C/T cg25024717 chr12:54324583 NA -0.39 -6.74 -0.35 6.93e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg12927641 chr6:109611667 NA 0.43 7.48 0.38 6.44e-13 Reticulocyte fraction of red cells; LUSC cis rs1729951 0.575 rs75976 chr3:136700455 G/A cg21827317 chr3:136751795 NA 0.38 6.86 0.35 3.34e-11 Neuroticism; LUSC cis rs11122272 0.735 rs2295420 chr1:231485640 C/T cg06096015 chr1:231504339 EGLN1 0.54 9.34 0.46 1.39e-18 Hemoglobin concentration; LUSC cis rs2361710 0.704 rs4889979 chr17:78121707 T/A cg06718696 chr17:78121285 EIF4A3 0.45 6.38 0.33 5.87e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs10423674 0.526 rs12462498 chr19:18832950 A/G cg14292368 chr19:18793705 CRTC1 0.44 6.94 0.35 2.08e-11 Menarche (age at onset); LUSC trans rs34421088 0.560 rs2248315 chr8:11397086 T/A cg15556689 chr8:8085844 FLJ10661 -0.59 -9.38 -0.46 1.06e-18 Neuroticism; LUSC trans rs61931739 0.534 rs10844791 chr12:34211659 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.62 0.43 2.81e-16 Morning vs. evening chronotype; LUSC cis rs75920871 0.588 rs721783 chr11:116907449 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.52 -6.59 -0.34 1.69e-10 Subjective well-being; LUSC cis rs908922 0.676 rs1337340 chr1:152508260 T/C cg20991723 chr1:152506922 NA 0.51 9.64 0.47 1.51e-19 Hair morphology; LUSC cis rs2548003 0.541 rs1895416 chr5:28754530 A/T cg22863700 chr5:28928346 NA 0.42 5.72 0.3 2.36e-8 Hip geometry; LUSC cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -7.07 -0.36 8.85e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.909 rs6060960 chr20:30394517 G/T cg18721089 chr20:30220636 NA 0.31 5.65 0.3 3.47e-8 Mean corpuscular hemoglobin; LUSC cis rs4808199 0.948 rs2074301 chr19:19381715 G/A cg03709012 chr19:19516395 GATAD2A 0.96 11.21 0.52 5.67e-25 Nonalcoholic fatty liver disease; LUSC cis rs17014483 0.749 rs3017902 chr4:89638082 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.68 5.97 0.31 5.92e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs6964587 0.692 rs10236483 chr7:91797296 A/C cg17063962 chr7:91808500 NA 0.58 9.62 0.47 1.68e-19 Breast cancer; LUSC cis rs9325144 0.560 rs7980635 chr12:38668355 G/T cg26384229 chr12:38710491 ALG10B -0.66 -10.27 -0.49 1.11e-21 Morning vs. evening chronotype; LUSC cis rs17095355 1.000 rs55728195 chr10:111715599 G/A cg00817464 chr10:111662876 XPNPEP1 -0.63 -7.93 -0.4 3.36e-14 Biliary atresia; LUSC trans rs9467603 0.925 rs6456701 chr6:25774130 C/T cg06606381 chr12:133084897 FBRSL1 0.59 5.95 0.31 6.9e-9 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.582 rs4917976 chr10:104360518 A/G cg05855489 chr10:104503620 C10orf26 0.49 7.41 0.38 1.05e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg03388025 chr16:89894329 SPIRE2 0.36 7.53 0.38 4.78e-13 Vitiligo; LUSC cis rs6087990 0.899 rs998382 chr20:31384136 C/T cg13636640 chr20:31349939 DNMT3B -0.95 -20.47 -0.75 6.48e-61 Ulcerative colitis; LUSC cis rs9287719 0.967 rs6721739 chr2:10751246 G/T cg03983476 chr2:10830698 NOL10 0.38 5.79 0.3 1.61e-8 Prostate cancer; LUSC cis rs7267979 0.586 rs1007707 chr20:25190598 A/G cg08601574 chr20:25228251 PYGB 0.43 6.66 0.34 1.11e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs7829975 0.514 rs2976929 chr8:8258712 T/C cg27411982 chr8:10470053 RP1L1 0.39 6.24 0.32 1.34e-9 Mood instability; LUSC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.98 0.4 2.38e-14 Parkinson's disease; LUSC cis rs2046867 0.818 rs6786469 chr3:72873809 A/G cg04365224 chr3:72788183 NA -0.49 -5.94 -0.31 7.13e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs1372520 0.684 rs2619355 chr4:90748374 A/C cg01966878 chr4:90757139 SNCA -0.42 -5.96 -0.31 6.24e-9 Neuroticism; LUSC cis rs208520 0.874 rs208473 chr6:66917265 G/C cg07460842 chr6:66804631 NA -1.01 -14.4 -0.62 6.88e-37 Exhaled nitric oxide output; LUSC cis rs1335645 0.570 rs6662965 chr1:111642226 C/A cg00321911 chr1:111669324 DRAM2 -0.59 -6.23 -0.32 1.39e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9467773 0.620 rs2101582 chr6:26622734 C/T cg09904177 chr6:26538194 HMGN4 0.66 12.02 0.55 6.77e-28 Intelligence (multi-trait analysis); LUSC cis rs617219 0.819 rs7711939 chr5:78599519 T/C cg24856658 chr5:78533917 JMY 0.3 5.93 0.31 7.68e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs5758511 0.773 rs8140869 chr22:42344297 A/G cg12850546 chr22:42539477 CYP2D7P1 0.46 5.77 0.3 1.79e-8 Birth weight; LUSC cis rs7511006 0.893 rs5771104 chr22:50651839 C/T cg08875078 chr22:50639485 SELO 0.44 6.19 0.32 1.77e-9 Obesity-related traits; LUSC cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg20283391 chr11:68216788 NA -0.58 -8.16 -0.41 6.89e-15 Total body bone mineral density; LUSC trans rs453301 0.571 rs2929456 chr8:9083416 G/A cg21775007 chr8:11205619 TDH -0.42 -5.99 -0.31 5.4e-9 Joint mobility (Beighton score); LUSC cis rs2120019 1.000 rs60425110 chr15:75333000 T/A cg17294928 chr15:75287854 SCAMP5 -0.92 -13.07 -0.58 8.12e-32 Blood trace element (Zn levels); LUSC cis rs9902453 0.868 rs8066731 chr17:28523121 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.36 0.46 1.21e-18 Coffee consumption (cups per day); LUSC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg13607699 chr17:42295918 UBTF -0.79 -15.17 -0.64 6.39e-40 Total body bone mineral density; LUSC cis rs3784262 1.000 rs11855259 chr15:58249377 C/G cg12031962 chr15:58353849 ALDH1A2 -0.34 -6.2 -0.32 1.68e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg18230493 chr5:56204884 C5orf35 -0.58 -9.31 -0.45 1.72e-18 Breast cancer;Breast cancer (early onset); LUSC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg07703079 chr11:430292 ANO9 0.61 6.64 0.34 1.26e-10 Body mass index; LUSC cis rs763121 0.853 rs6519119 chr22:38989007 C/G cg06022373 chr22:39101656 GTPBP1 0.77 11.95 0.55 1.22e-27 Menopause (age at onset); LUSC cis rs897984 0.683 rs8046001 chr16:30833321 C/T cg02466173 chr16:30829666 NA -0.69 -16.41 -0.67 8.62e-45 Dementia with Lewy bodies; LUSC cis rs372883 0.901 rs13048365 chr21:30740394 T/C cg08807101 chr21:30365312 RNF160 0.43 6.36 0.33 6.8e-10 Pancreatic cancer; LUSC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg02569458 chr12:86230093 RASSF9 0.48 7.72 0.39 1.41e-13 Major depressive disorder; LUSC cis rs1801251 1.000 rs2100053 chr2:233719516 G/T cg08000102 chr2:233561755 GIGYF2 -0.68 -11.39 -0.53 1.24e-25 Coronary artery disease; LUSC cis rs4654899 0.929 rs7515845 chr1:21314455 G/A cg01072550 chr1:21505969 NA -0.56 -8.5 -0.42 6.28e-16 Superior frontal gyrus grey matter volume; LUSC cis rs9420 0.961 rs7936998 chr11:57639017 G/A cg02958346 chr11:57425731 CLP1 -0.44 -6.33 -0.33 8.01e-10 Schizophrenia; LUSC cis rs4919694 0.611 rs75182663 chr10:105058104 A/G cg04362960 chr10:104952993 NT5C2 1.04 10.73 0.51 2.73e-23 Arsenic metabolism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13912035 chr5:179105622 CBY3 -0.42 -6.17 -0.32 1.96e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.76e-13 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.510 rs1727323 chr12:123698790 T/C cg05973401 chr12:123451056 ABCB9 0.52 6.6 0.34 1.64e-10 Neutrophil percentage of white cells; LUSC cis rs7617480 0.648 rs6796790 chr3:48780317 G/A cg07636037 chr3:49044803 WDR6 0.94 12.97 0.58 1.9e-31 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg18512352 chr11:47633146 NA 0.45 9.05 0.44 1.22e-17 Subjective well-being; LUSC cis rs6918586 0.658 rs198828 chr6:26119459 G/A cg17691542 chr6:26056736 HIST1H1C 0.4 5.94 0.31 7.21e-9 Schizophrenia; LUSC cis rs4964805 0.594 rs11111759 chr12:104163183 T/C cg02344784 chr12:104178138 NT5DC3 0.36 5.86 0.31 1.09e-8 Attention deficit hyperactivity disorder; LUSC cis rs6121246 0.909 rs6089071 chr20:30378384 C/G cg18721089 chr20:30220636 NA -0.34 -6.01 -0.31 4.97e-9 Mean corpuscular hemoglobin; LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg13560548 chr3:10150139 C3orf24 0.53 7.2 0.37 3.99e-12 Alzheimer's disease; LUSC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg07701084 chr6:150067640 NUP43 0.57 8.85 0.44 5.05e-17 Lung cancer; LUSC cis rs1595825 0.891 rs996427 chr2:198685609 G/A cg10547527 chr2:198650123 BOLL -0.51 -5.9 -0.31 8.72e-9 Ulcerative colitis; LUSC cis rs9399135 0.967 rs13218642 chr6:135309940 A/G cg24558204 chr6:135376177 HBS1L 0.59 9.26 0.45 2.5e-18 Red blood cell count; LUSC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC cis rs9517302 0.847 rs9517297 chr13:99094961 A/C cg22223119 chr13:99095684 FARP1 -0.73 -11.53 -0.53 4.04e-26 Obesity-related traits; LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.53 6.58 0.34 1.8e-10 Renal function-related traits (BUN); LUSC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg17911788 chr17:44343683 NA 0.31 6.06 0.31 3.61e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs1185460 0.547 rs667584 chr11:118911544 C/T cg01677386 chr11:118938358 VPS11 0.44 6.35 0.33 7.22e-10 Coronary artery disease; LUSC trans rs4269383 0.774 rs9397275 chr6:156255097 A/G cg11658975 chr6:170700107 FAM120B 0.35 5.95 0.31 6.6e-9 Pancreatic cancer; LUSC cis rs4474465 0.688 rs7940720 chr11:78276674 C/T cg27205649 chr11:78285834 NARS2 0.55 6.95 0.36 1.97e-11 Alzheimer's disease (survival time); LUSC cis rs2742417 1.000 rs2673047 chr3:45743113 A/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.5 -0.38 5.91e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg22834771 chr12:69754056 YEATS4 -0.5 -7.45 -0.38 8.09e-13 Blood protein levels; LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg02475777 chr4:1388615 CRIPAK -0.59 -8.88 -0.44 4.2e-17 Obesity-related traits; LUSC trans rs2739330 0.828 rs5760099 chr22:24248414 G/A cg06437703 chr8:37914619 EIF4EBP1 -0.56 -8.72 -0.43 1.31e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg27094323 chr7:1216898 NA -0.43 -7.35 -0.37 1.51e-12 Longevity;Endometriosis; LUSC cis rs16976116 1.000 rs16976116 chr15:55480467 T/C cg11288833 chr15:55489084 RSL24D1 0.52 6.28 0.33 1.04e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs72781680 0.752 rs72796130 chr2:23919740 T/C cg08917208 chr2:24149416 ATAD2B 1.0 10.21 0.49 1.77e-21 Lymphocyte counts; LUSC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13732083 chr21:47605072 C21orf56 0.42 6.21 0.32 1.55e-9 Testicular germ cell tumor; LUSC cis rs501916 0.761 rs79925748 chr15:48046412 G/C cg16110827 chr15:48056943 SEMA6D -0.44 -6.74 -0.35 6.87e-11 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.71 -0.39 1.43e-13 Lymphocyte counts; LUSC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg21699342 chr2:239360505 ASB1 -0.54 -10.03 -0.48 6.95e-21 Multiple system atrophy; LUSC cis rs16986825 0.607 rs5762852 chr22:29242473 T/C cg02153584 chr22:29168773 CCDC117 0.53 6.04 0.31 4.15e-9 Pancreatic cancer; LUSC cis rs2067615 0.579 rs10778510 chr12:107162965 A/G cg15890332 chr12:107067104 RFX4 -0.34 -6.14 -0.32 2.41e-9 Heart rate; LUSC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg04455712 chr21:45112962 RRP1B 0.49 9.27 0.45 2.37e-18 Mean corpuscular volume; LUSC cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg02753203 chr1:228287806 NA -0.65 -11.16 -0.52 8.28e-25 Diastolic blood pressure; LUSC cis rs4924935 0.851 rs12936834 chr17:18807078 A/G cg26306683 chr17:18585705 ZNF286B 0.54 7.35 0.37 1.57e-12 Pancreatic cancer; LUSC cis rs4304924 0.500 rs2281856 chr13:79207644 C/T cg07937631 chr13:79184529 NA 0.36 6.08 0.32 3.3e-9 Large artery stroke; LUSC cis rs6541297 1.000 rs7543050 chr1:230278291 C/G cg20703242 chr1:230279135 GALNT2 0.5 7.58 0.38 3.37e-13 Coronary artery disease; LUSC cis rs7584330 0.910 rs880930 chr2:238396872 G/C cg14458575 chr2:238380390 NA 0.71 12.44 0.56 1.93e-29 Prostate cancer; LUSC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg01657329 chr11:68192670 LRP5 -0.45 -7.24 -0.37 3.17e-12 Total body bone mineral density; LUSC cis rs12602172 1 rs12602172 chr17:38163567 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.94 -0.36 1.99e-11 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg21435336 chr19:17392852 ANKLE1 -0.45 -6.19 -0.32 1.79e-9 Systemic lupus erythematosus; LUSC cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg03433033 chr1:76189801 ACADM -0.48 -7.18 -0.37 4.59e-12 Daytime sleep phenotypes; LUSC cis rs239198 0.602 rs11755579 chr6:101322469 A/C cg09795085 chr6:101329169 ASCC3 0.45 6.36 0.33 6.54e-10 Menarche (age at onset); LUSC cis rs1577917 0.958 rs12192546 chr6:86476484 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.64 9.13 0.45 6.68e-18 Response to antipsychotic treatment; LUSC cis rs9527 0.590 rs34104646 chr10:104896078 T/A cg05855489 chr10:104503620 C10orf26 0.52 8.06 0.4 1.35e-14 Arsenic metabolism; LUSC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs892085 0.681 rs873016 chr19:10894728 G/A cg17710535 chr19:10819994 QTRT1 0.36 5.76 0.3 1.93e-8 Psoriasis vulgaris;Psoriasis; LUSC cis rs1577917 0.958 rs2660576 chr6:86651603 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.38 -0.42 1.49e-15 Response to antipsychotic treatment; LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg07362569 chr17:61921086 SMARCD2 -0.31 -6.19 -0.32 1.78e-9 Prudent dietary pattern; LUSC trans rs984440 0.560 rs7816346 chr8:139084529 A/G cg03334052 chr1:168888044 NA -0.41 -6.56 -0.34 2.04e-10 Obesity-related traits; LUSC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.03 0.31 4.42e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs354225 0.584 rs7591231 chr2:54829596 C/G cg26097391 chr2:54893211 SPTBN1 0.42 6.27 0.32 1.14e-9 Schizophrenia; LUSC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg03929089 chr4:120376271 NA -1.03 -20.21 -0.74 7.12e-60 Height; LUSC cis rs1799949 0.965 rs7223952 chr17:41194885 T/C cg05368731 chr17:41323189 NBR1 0.86 14.28 0.62 1.85e-36 Menopause (age at onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg22078572 chr18:61033618 KDSR -0.46 -6.07 -0.32 3.45e-9 Hepatitis; LUSC trans rs7980799 0.682 rs61927702 chr12:33631695 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.33 -0.33 7.72e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs6545883 0.894 rs7572603 chr2:61552145 C/G cg15711740 chr2:61764176 XPO1 0.43 6.67 0.34 1.03e-10 Tuberculosis; LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.5 0.34 2.94e-10 Menopause (age at onset); LUSC cis rs7584330 0.704 rs72620820 chr2:238358844 G/A cg16989719 chr2:238392110 NA -0.45 -7.15 -0.36 5.66e-12 Prostate cancer; LUSC cis rs478304 0.651 rs11604451 chr11:65551710 C/T cg10518572 chr11:65560635 OVOL1 -0.26 -5.98 -0.31 5.73e-9 Acne (severe); LUSC cis rs10887741 1.000 rs12412482 chr10:89443799 C/T cg13926569 chr10:89418898 PAPSS2 0.31 6.23 0.32 1.43e-9 Exercise (leisure time); LUSC cis rs6704644 0.651 rs11675254 chr2:234364047 C/T cg05711037 chr2:234359783 DGKD 0.61 6.7 0.34 8.61e-11 Bilirubin levels; LUSC cis rs694739 0.857 rs574835 chr11:64110668 G/A cg26898376 chr11:64110657 CCDC88B 0.36 6.84 0.35 3.81e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg09307838 chr4:120376055 NA 0.79 11.59 0.54 2.5e-26 Corneal astigmatism; LUSC cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.9 -0.55 1.86e-27 Chronic sinus infection; LUSC cis rs7572733 0.555 rs13395030 chr2:198750806 A/G cg00792783 chr2:198669748 PLCL1 0.46 6.15 0.32 2.17e-9 Dermatomyositis; LUSC cis rs61931739 0.500 rs7307583 chr12:34521711 T/C cg06521331 chr12:34319734 NA -0.41 -6.8 -0.35 4.96e-11 Morning vs. evening chronotype; LUSC cis rs17095355 1.000 rs12246851 chr10:111726340 C/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.54 -0.38 4.55e-13 Biliary atresia; LUSC cis rs4363385 0.719 rs2066005 chr1:152923113 G/C cg07796016 chr1:152779584 LCE1C -0.49 -7.02 -0.36 1.25e-11 Inflammatory skin disease; LUSC cis rs1865760 1.000 rs12209482 chr6:25909229 T/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.87 0.35 3.11e-11 Height; LUSC cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.42 0.38 9.93e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs12519773 0.502 rs4613686 chr5:92498497 A/G cg18783429 chr5:92414398 NA 0.36 7.87 0.4 4.91e-14 Migraine; LUSC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg21724239 chr8:58056113 NA 0.57 6.58 0.34 1.87e-10 Developmental language disorder (linguistic errors); LUSC cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.17 -0.32 2.02e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7809950 0.911 rs1015411 chr7:107135612 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.96 -0.44 2.31e-17 Coronary artery disease; LUSC cis rs34779708 0.966 rs11010122 chr10:35493518 A/C cg04310649 chr10:35416472 CREM -0.4 -6.24 -0.32 1.35e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg01528321 chr10:82214614 TSPAN14 0.62 8.94 0.44 2.67e-17 Post bronchodilator FEV1; LUSC cis rs2267137 0.903 rs715494 chr22:29782433 G/T cg07256473 chr22:29710276 RASL10A -0.38 -7.36 -0.37 1.4e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC trans rs9393777 0.920 rs72839445 chr6:27249686 G/A cg06606381 chr12:133084897 FBRSL1 -0.92 -8.28 -0.41 3e-15 Intelligence (multi-trait analysis); LUSC trans rs6076960 0.744 rs6053961 chr20:6176793 A/G cg21095983 chr6:86352623 SYNCRIP 0.39 6.02 0.31 4.66e-9 Smooth-surface caries; LUSC trans rs4689592 0.513 rs3857177 chr4:7066332 G/A cg07817883 chr1:32538562 TMEM39B -0.61 -7.45 -0.38 7.97e-13 Monocyte percentage of white cells; LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg08280861 chr8:58055591 NA 0.54 6.44 0.33 4.06e-10 Developmental language disorder (linguistic errors); LUSC trans rs11992162 0.591 rs35657308 chr8:11804402 G/A cg15556689 chr8:8085844 FLJ10661 -0.51 -7.43 -0.38 9.37e-13 Monocyte count; LUSC cis rs12760731 0.565 rs7550699 chr1:178209584 T/G cg00404053 chr1:178313656 RASAL2 0.68 6.9 0.35 2.55e-11 Obesity-related traits; LUSC cis rs6674970 0.777 rs12087892 chr1:151118500 T/C cg11822372 chr1:151115635 SEMA6C -0.84 -13.58 -0.6 9.82e-34 Childhood ear infection; LUSC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.71 0.51 3.24e-23 Menopause (age at onset); LUSC cis rs17253792 0.731 rs3736876 chr14:56120178 T/C cg01858014 chr14:56050164 KTN1 -0.8 -6.58 -0.34 1.79e-10 Putamen volume; LUSC cis rs7584330 0.554 rs880931 chr2:238396741 G/A cg14458575 chr2:238380390 NA 0.7 8.47 0.42 7.99e-16 Prostate cancer; LUSC trans rs12310956 0.532 rs1589902 chr12:33989289 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.83 0.51 1.22e-23 Morning vs. evening chronotype; LUSC cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7944584 0.545 rs7118178 chr11:47659135 G/A cg20307385 chr11:47447363 PSMC3 0.84 11.99 0.55 8.91e-28 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06861087 chr14:53019167 TXNDC16;GPR137C -0.41 -6.09 -0.32 3.06e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg04800585 chr6:26043546 HIST1H2BB 0.38 5.65 0.3 3.35e-8 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20964285 chr5:65892109 MAST4 -0.42 -6.19 -0.32 1.73e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg14552801 chr7:65878734 NA -0.46 -6.69 -0.34 9.24e-11 Aortic root size; LUSC cis rs7927592 0.956 rs7116899 chr11:68385535 G/T cg16797656 chr11:68205561 LRP5 0.35 5.94 0.31 7.22e-9 Total body bone mineral density; LUSC cis rs1153858 1.000 rs1153858 chr15:45652703 A/G cg26924012 chr15:45694286 SPATA5L1 -1.13 -20.97 -0.75 7.04e-63 Homoarginine levels; LUSC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg13393036 chr8:95962371 TP53INP1 -0.34 -6.52 -0.34 2.52e-10 Type 2 diabetes; LUSC cis rs9300255 0.602 rs11057192 chr12:123693420 T/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs10078 0.559 rs2672725 chr5:434981 G/C cg08916839 chr5:415575 AHRR 0.77 7.39 0.38 1.15e-12 Fat distribution (HIV); LUSC cis rs1691799 0.867 rs1168356 chr12:66750469 A/G cg16791601 chr12:66731901 HELB -0.73 -12.43 -0.56 2.12e-29 White blood cell count (basophil); LUSC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg16520312 chr17:43971471 MAPT;LOC100128977 0.36 6.15 0.32 2.16e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs72960926 0.744 rs117811116 chr6:74898143 C/A cg03266952 chr6:74778945 NA -0.8 -6.24 -0.32 1.3e-9 Metabolite levels (MHPG); LUSC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg12826209 chr6:26865740 GUSBL1 0.76 9.22 0.45 3.51e-18 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg05863683 chr7:1912471 MAD1L1 -0.3 -5.68 -0.3 2.96e-8 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg23051282 chr17:78940161 RPTOR 0.45 6.29 0.33 9.86e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11098499 0.722 rs7673476 chr4:120248683 C/T cg09307838 chr4:120376055 NA 0.66 9.89 0.48 2.09e-20 Corneal astigmatism; LUSC cis rs9811920 0.809 rs902159 chr3:99747445 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.37 7.09 0.36 8.18e-12 Axial length; LUSC cis rs4566357 1.000 rs1317770 chr2:227911725 C/T cg11843606 chr2:227700838 RHBDD1 -0.42 -5.84 -0.3 1.23e-8 Coronary artery disease; LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg20887711 chr4:1340912 KIAA1530 0.44 6.57 0.34 1.97e-10 Obesity-related traits; LUSC cis rs6580649 0.941 rs1793931 chr12:48396505 G/T cg24011408 chr12:48396354 COL2A1 0.58 7.76 0.39 1.06e-13 Lung cancer; LUSC cis rs10782582 0.593 rs11579752 chr1:76178694 C/T cg10523679 chr1:76189770 ACADM -0.46 -6.51 -0.34 2.74e-10 Daytime sleep phenotypes; LUSC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg06873352 chr17:61820015 STRADA 0.58 8.99 0.44 1.82e-17 Height; LUSC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC trans rs71435601 0.657 rs10221876 chr2:21419809 A/T cg20757404 chr19:378427 NA -0.41 -6.32 -0.33 8.46e-10 Cholesterol, total; LUSC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg25019033 chr10:957182 NA -0.51 -5.68 -0.3 2.9e-8 Eosinophil percentage of granulocytes; LUSC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg11812906 chr14:75593930 NEK9 -0.62 -10.33 -0.49 6.91e-22 Height; LUSC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg26566898 chr11:117069891 TAGLN 0.31 5.86 0.31 1.13e-8 Blood protein levels; LUSC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg03684893 chr10:554711 DIP2C -0.38 -6.96 -0.36 1.79e-11 Psychosis in Alzheimer's disease; LUSC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2073300 1.000 rs115730610 chr20:23442621 G/A cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7223966 1.000 rs7217982 chr17:61832150 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.03 0.31 4.4e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6696846 0.936 rs1042831 chr1:205043250 G/C cg00857998 chr1:205179979 DSTYK 0.65 9.84 0.47 3.12e-20 Red blood cell count; LUSC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg17211192 chr8:82754475 SNX16 -0.64 -9.11 -0.45 7.56e-18 Diastolic blood pressure; LUSC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg06238570 chr21:40685208 BRWD1 -0.62 -10.95 -0.51 4.73e-24 Cognitive function; LUSC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg13939156 chr17:80058883 NA -0.33 -6.49 -0.33 3.15e-10 Life satisfaction; LUSC cis rs9650315 0.866 rs13260966 chr8:57182832 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.49 6.41 0.33 4.87e-10 Height; LUSC cis rs3540 0.618 rs2301832 chr15:91040725 A/T cg10434728 chr15:90938212 IQGAP1 -0.45 -9.18 -0.45 4.59e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs13082711 0.911 rs57317249 chr3:27515854 A/C cg02860705 chr3:27208620 NA 0.47 7.91 0.4 3.88e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg06740227 chr12:86229804 RASSF9 0.45 7.14 0.36 5.83e-12 Major depressive disorder; LUSC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg02038168 chr22:39784481 NA -0.43 -6.26 -0.32 1.21e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs300703 0.515 rs300695 chr2:182644 C/A cg21211680 chr2:198530 NA -0.54 -6.68 -0.34 9.72e-11 Blood protein levels; LUSC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg06873352 chr17:61820015 STRADA -0.64 -11.62 -0.54 1.91e-26 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg17554472 chr22:41940697 POLR3H 0.48 5.9 0.31 8.76e-9 Vitiligo; LUSC cis rs9818941 0.824 rs2712318 chr3:157776053 C/T cg08654915 chr3:157813417 NA -0.33 -7.68 -0.39 1.73e-13 Height; LUSC cis rs34779708 0.966 rs17499247 chr10:35426755 A/G cg04310649 chr10:35416472 CREM -0.42 -6.59 -0.34 1.74e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg14582100 chr15:45693742 SPATA5L1 0.59 10.79 0.51 1.81e-23 Homoarginine levels; LUSC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.76 10.43 0.5 3.16e-22 Age-related macular degeneration (geographic atrophy); LUSC cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg14196790 chr5:131705035 SLC22A5 0.5 8.46 0.42 8.3e-16 Blood metabolite levels; LUSC cis rs9814567 1.000 rs9985356 chr3:134232920 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.77 12.74 0.57 1.47e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7707921 0.957 rs226205 chr5:81593654 C/T cg15871215 chr5:81402204 ATG10 0.41 5.72 0.3 2.38e-8 Breast cancer; LUSC cis rs17818399 0.708 rs13000706 chr2:46838247 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.4 -6.0 -0.31 5.17e-9 Height; LUSC trans rs12692738 0.526 rs355856 chr2:165628977 T/A cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4924935 0.851 rs12936834 chr17:18807078 A/G cg26378065 chr17:18585709 ZNF286B 0.6 8.24 0.41 3.87e-15 Pancreatic cancer; LUSC cis rs6964587 1.000 rs4265 chr7:91719608 A/G cg01689657 chr7:91764605 CYP51A1 -0.33 -5.87 -0.31 1.06e-8 Breast cancer; LUSC cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg26373071 chr5:1325741 CLPTM1L 0.42 7.81 0.39 7.35e-14 Lung cancer; LUSC cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg23158103 chr7:148848205 ZNF398 -0.43 -6.47 -0.33 3.43e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7582180 0.663 rs2053263 chr2:100971407 A/G cg12002119 chr2:101014098 CHST10 0.34 5.66 0.3 3.21e-8 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.866 rs6847778 chr4:120293582 A/G cg24375607 chr4:120327624 NA 0.71 10.38 0.49 4.68e-22 Corneal astigmatism; LUSC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.86 -0.35 3.35e-11 Alzheimer's disease (late onset); LUSC cis rs7818345 1.000 rs7835461 chr8:19307051 C/T cg11303988 chr8:19266685 CSGALNACT1 0.35 6.49 0.33 3.19e-10 Language performance in older adults (adjusted for episodic memory); LUSC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg18876405 chr7:65276391 NA 0.76 13.71 0.6 3.02e-34 Aortic root size; LUSC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg13390004 chr1:15929781 NA 0.4 6.74 0.35 7.14e-11 Systolic blood pressure; LUSC cis rs7267979 0.934 rs2482913 chr20:25405086 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.52 -0.69 3.23e-49 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7809950 1.000 rs7778270 chr7:107224667 A/G cg23024343 chr7:107201750 COG5 0.57 8.81 0.43 6.71e-17 Coronary artery disease; LUSC cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg19508488 chr2:152266495 RIF1 0.56 7.9 0.4 3.96e-14 Lung cancer; LUSC cis rs7264396 0.563 rs2425138 chr20:34345710 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -7.65 -0.39 2.13e-13 Total cholesterol levels; LUSC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg04865166 chr7:105162814 PUS7 0.51 5.7 0.3 2.65e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9325144 0.560 rs11182979 chr12:38642562 C/A cg26384229 chr12:38710491 ALG10B -0.66 -10.16 -0.49 2.59e-21 Morning vs. evening chronotype; LUSC cis rs11971779 0.680 rs11772026 chr7:139052589 T/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11644478 chr21:40555479 PSMG1 0.82 15.09 0.64 1.36e-39 Cognitive function; LUSC cis rs533581 0.873 rs579740 chr16:88973937 A/G cg16701003 chr16:89028210 CBFA2T3 -0.41 -7.56 -0.38 3.97e-13 Social autistic-like traits; LUSC cis rs11122272 0.701 rs743120 chr1:231531232 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.25 -0.49 1.28e-21 Hemoglobin concentration; LUSC cis rs2688608 0.967 rs2688609 chr10:75658181 A/G cg23231163 chr10:75533350 FUT11 0.39 6.39 0.33 5.44e-10 Inflammatory bowel disease; LUSC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg11764359 chr7:65958608 NA 0.7 11.0 0.52 3.29e-24 Aortic root size; LUSC cis rs4363385 0.510 rs6587724 chr1:153034501 T/A cg25856811 chr1:152973957 SPRR3 -0.37 -6.13 -0.32 2.44e-9 Inflammatory skin disease; LUSC cis rs911119 1.000 rs73318135 chr20:23618571 T/G cg16589663 chr20:23618590 CST3 0.6 7.0 0.36 1.39e-11 Chronic kidney disease; LUSC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg19774624 chr17:42201019 HDAC5 0.7 10.49 0.5 1.99e-22 Total body bone mineral density; LUSC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.81 -0.35 4.67e-11 Lung cancer; LUSC cis rs757110 0.866 rs5215 chr11:17408630 C/T cg15432903 chr11:17409602 KCNJ11 0.63 11.34 0.53 1.98e-25 Type 2 diabetes; LUSC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg13393036 chr8:95962371 TP53INP1 -0.51 -11.18 -0.52 7.54e-25 Type 2 diabetes; LUSC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg11632617 chr15:75315747 PPCDC -0.52 -6.78 -0.35 5.39e-11 Blood trace element (Zn levels); LUSC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg04267008 chr7:1944627 MAD1L1 -0.59 -9.01 -0.44 1.57e-17 Bipolar disorder and schizophrenia; LUSC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg18357526 chr6:26021779 HIST1H4A 0.44 6.59 0.34 1.72e-10 Intelligence (multi-trait analysis); LUSC cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.93 0.31 7.55e-9 Rheumatoid arthritis; LUSC cis rs4889855 0.556 rs11547301 chr17:78518780 C/T cg16591659 chr17:78472290 NA 0.32 5.66 0.3 3.29e-8 Fractional excretion of uric acid; LUSC cis rs1997103 0.911 rs17777 chr7:55380765 T/C cg17469321 chr7:55412551 NA 0.67 10.4 0.49 3.79e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11890956 chr21:40555474 PSMG1 -0.95 -17.57 -0.69 2.07e-49 Cognitive function; LUSC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg15813090 chr5:442598 EXOC3;C5orf55 0.39 6.15 0.32 2.16e-9 Cystic fibrosis severity; LUSC cis rs8114671 0.628 rs6060130 chr20:33549319 C/T cg07148914 chr20:33460835 GGT7 0.49 7.38 0.37 1.24e-12 Height; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg01854491 chr8:144815021 FAM83H -0.22 -6.03 -0.31 4.27e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg12463550 chr7:65579703 CRCP 0.55 8.19 0.41 5.73e-15 Aortic root size; LUSC cis rs7107174 0.892 rs2510042 chr11:77923665 C/T cg02023728 chr11:77925099 USP35 0.53 7.53 0.38 4.91e-13 Testicular germ cell tumor; LUSC cis rs9611565 0.921 rs5751080 chr22:41736267 A/G cg03806693 chr22:41940476 POLR3H -0.74 -10.94 -0.51 5.32e-24 Vitiligo; LUSC trans rs2797160 1.000 rs2747714 chr6:126007620 A/G cg05039488 chr6:79577232 IRAK1BP1 0.45 6.66 0.34 1.16e-10 Endometrial cancer; LUSC cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg23158103 chr7:148848205 ZNF398 -0.47 -7.53 -0.38 4.81e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7246657 0.943 rs8109632 chr19:37931125 A/T cg23950597 chr19:37808831 NA -0.62 -7.47 -0.38 6.98e-13 Coronary artery calcification; LUSC cis rs2625529 0.816 rs8025504 chr15:72294757 C/T cg16672083 chr15:72433130 SENP8 -0.52 -7.58 -0.38 3.51e-13 Red blood cell count; LUSC cis rs698813 0.674 rs6544752 chr2:44499049 G/A cg00619915 chr2:44497795 NA -0.5 -6.83 -0.35 3.91e-11 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs7123876 0.587 rs11600831 chr11:72360220 C/T cg03713592 chr11:72463424 ARAP1 0.69 7.18 0.37 4.54e-12 Body mass index; LUSC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg20887711 chr4:1340912 KIAA1530 0.49 7.75 0.39 1.1e-13 Obesity-related traits; LUSC cis rs2067615 0.542 rs4433659 chr12:107082496 G/T cg15890332 chr12:107067104 RFX4 0.35 6.27 0.32 1.08e-9 Heart rate; LUSC cis rs1538970 0.924 rs1494812 chr1:45876999 C/T cg05343316 chr1:45956843 TESK2 0.62 8.63 0.43 2.49e-16 Platelet count; LUSC cis rs977987 0.806 rs8050769 chr16:75388434 C/T cg04384234 chr16:75411784 CFDP1 -0.39 -6.25 -0.32 1.22e-9 Dupuytren's disease; LUSC cis rs7605378 0.567 rs717915 chr2:200714766 C/T cg17644776 chr2:200775616 C2orf69 0.52 8.94 0.44 2.74e-17 Osteoporosis; LUSC cis rs3790515 0.826 rs2280471 chr1:151783736 A/G cg07092448 chr1:151763213 TDRKH 0.7 5.97 0.31 6.13e-9 Depressive symptoms (SSRI exposure interaction); LUSC cis rs3126085 0.877 rs7537633 chr1:152223333 T/G cg26876637 chr1:152193138 HRNR 0.44 6.2 0.32 1.7e-9 Atopic dermatitis; LUSC cis rs7246967 0.611 rs7250964 chr19:22822494 T/C cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs2290416 0.892 rs76225457 chr8:144666052 G/T cg08017634 chr8:144659831 NAPRT1 0.71 6.01 0.31 4.81e-9 Attention deficit hyperactivity disorder; LUSC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg25703541 chr22:24373054 LOC391322 -0.94 -17.19 -0.69 6.69e-48 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.18 0.32 1.83e-9 Lung cancer; LUSC cis rs9436747 0.585 rs11581702 chr1:65987659 T/C cg14976592 chr1:65886160 LEPROT;LEPR -0.44 -5.9 -0.31 9.08e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs1865760 0.663 rs9348704 chr6:26000393 A/C cg16482183 chr6:26056742 HIST1H1C 0.47 7.06 0.36 9.87e-12 Height; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg05064044 chr6:292385 DUSP22 -0.52 -7.6 -0.38 3.09e-13 Menopause (age at onset); LUSC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.92 -0.35 2.25e-11 Monocyte percentage of white cells; LUSC cis rs8114671 0.967 rs3746427 chr20:33730464 A/G cg07148914 chr20:33460835 GGT7 0.48 7.26 0.37 2.72e-12 Height; LUSC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -8.02 -0.4 1.8e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs1055129 0.560 rs2305913 chr17:73922941 T/C cg17515076 chr17:73810948 UNK -0.39 -6.46 -0.33 3.6e-10 White matter hyperintensity burden; LUSC trans rs800082 0.698 rs800070 chr3:144346614 A/T cg24215973 chr2:240111563 HDAC4 -0.7 -10.3 -0.49 8.74e-22 Smoking behavior; LUSC cis rs13256369 0.802 rs13280101 chr8:8562773 G/A cg17143192 chr8:8559678 CLDN23 0.64 9.02 0.44 1.47e-17 Obesity-related traits; LUSC cis rs617219 0.853 rs10078815 chr5:78522895 C/T cg24856658 chr5:78533917 JMY -0.3 -5.85 -0.31 1.14e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs10832963 1.000 rs11024739 chr11:18645843 A/C cg09201001 chr11:18656081 SPTY2D1 -0.89 -14.44 -0.62 4.72e-37 Breast cancer; LUSC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs9341808 0.718 rs10943696 chr6:80901272 C/G cg08355045 chr6:80787529 NA 0.59 10.22 0.49 1.64e-21 Sitting height ratio; LUSC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg05973401 chr12:123451056 ABCB9 0.53 7.26 0.37 2.68e-12 Height;Educational attainment;Head circumference (infant); LUSC cis rs1322512 0.874 rs2758768 chr6:152986239 C/T cg27316956 chr6:152958899 SYNE1 0.37 6.32 0.33 8.37e-10 Tonometry; LUSC cis rs868036 0.718 rs3784710 chr15:68072458 T/C cg08079166 chr15:68083412 MAP2K5 0.42 7.46 0.38 7.41e-13 Restless legs syndrome; LUSC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg22105103 chr4:187893119 NA 0.71 13.88 0.6 6.72e-35 Lobe attachment (rater-scored or self-reported); LUSC trans rs72674100 1.000 rs72882340 chr4:97993584 A/C cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs754466 0.651 rs55738779 chr10:79652395 C/T cg17075019 chr10:79541650 NA -0.74 -11.86 -0.54 2.56e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg18721089 chr20:30220636 NA -0.35 -5.88 -0.31 1.01e-8 Monocyte count; LUSC cis rs477692 0.905 rs576560 chr10:131420697 C/A cg11019008 chr10:131425282 MGMT 0.4 6.2 0.32 1.68e-9 Response to temozolomide; LUSC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.37e-34 Diabetic kidney disease; LUSC cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg16339924 chr4:17578868 LAP3 -0.55 -8.41 -0.42 1.22e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11585357 0.947 rs11585119 chr1:17605792 C/A cg08277548 chr1:17600880 PADI3 -0.68 -6.88 -0.35 2.88e-11 Hair shape; LUSC cis rs7178572 0.568 rs12443386 chr15:77491389 C/T cg22256960 chr15:77711686 NA 0.48 7.73 0.39 1.24e-13 Type 2 diabetes; LUSC cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg12011299 chr4:100065546 ADH4 -0.71 -11.17 -0.52 7.69e-25 Alcohol dependence; LUSC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg20295408 chr7:1910781 MAD1L1 -0.5 -7.18 -0.37 4.55e-12 Bipolar disorder and schizophrenia; LUSC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.54e-9 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.933 rs6138571 chr20:25435388 A/G cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg14343924 chr8:8086146 FLJ10661 -0.4 -5.65 -0.3 3.37e-8 Mood instability; LUSC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg10792982 chr14:105748885 BRF1 0.52 9.43 0.46 7.25e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg00431813 chr7:1051703 C7orf50 -0.43 -6.93 -0.35 2.19e-11 Longevity;Endometriosis; LUSC cis rs12594515 1.000 rs57299255 chr15:45996532 C/A cg01629716 chr15:45996671 NA 0.39 5.83 0.3 1.31e-8 Waist circumference;Weight; LUSC cis rs2898681 0.561 rs7699960 chr4:53735661 C/A cg21521518 chr4:53727714 RASL11B 0.45 5.92 0.31 7.81e-9 Optic nerve measurement (cup area); LUSC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg10802521 chr3:52805072 NEK4 -0.53 -7.66 -0.39 1.98e-13 Bipolar disorder; LUSC cis rs992157 1.000 rs992157 chr2:219154781 A/G cg00012203 chr2:219082015 ARPC2 -0.73 -12.77 -0.57 1.11e-30 Colorectal cancer; LUSC trans rs72674100 1.000 rs72874654 chr4:97966415 A/G cg09670535 chr1:18959427 PAX7 -0.64 -6.61 -0.34 1.53e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.65 9.99 0.48 9.81e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg09467607 chr2:36825704 FEZ2 0.54 11.12 0.52 1.22e-24 Height; LUSC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.02 -0.44 1.53e-17 Gut microbiome composition (summer); LUSC cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg22508957 chr16:3507546 NAT15 -0.41 -5.84 -0.3 1.25e-8 Body mass index (adult); LUSC cis rs73198271 0.515 rs75155748 chr8:8628957 G/C cg01851573 chr8:8652454 MFHAS1 0.61 7.01 0.36 1.34e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1997103 0.954 rs1917769 chr7:55392325 T/A cg17469321 chr7:55412551 NA 0.68 10.92 0.51 5.92e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg00071950 chr4:10020882 SLC2A9 -0.49 -8.23 -0.41 4.17e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs372883 0.507 rs8132992 chr21:30750561 T/C cg24692254 chr21:30365293 RNF160 0.68 10.88 0.51 8.46e-24 Pancreatic cancer; LUSC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg16624210 chr5:671434 TPPP 0.48 6.12 0.32 2.67e-9 Obesity-related traits; LUSC cis rs35146811 0.735 rs1636978 chr7:99813912 G/A cg13334819 chr7:99746414 C7orf59 0.5 6.73 0.35 7.31e-11 Coronary artery disease; LUSC cis rs7647973 0.710 rs9869120 chr3:49624065 T/C cg13072238 chr3:49761600 GMPPB -0.69 -8.14 -0.41 8.15e-15 Menarche (age at onset); LUSC cis rs3862030 0.839 rs2274351 chr10:104264107 C/T cg05855489 chr10:104503620 C10orf26 0.5 7.53 0.38 4.72e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.96 0.7 5.97e-51 Chronic sinus infection; LUSC cis rs17608059 0.504 rs11656981 chr17:13978777 A/G cg11395062 chr17:14139857 CDRT15 0.48 7.22 0.37 3.52e-12 Temperament; LUSC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -11.24 -0.52 4.49e-25 Systemic lupus erythematosus; LUSC cis rs1577917 0.771 rs12205013 chr6:86333029 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -11.1 -0.52 1.43e-24 Response to antipsychotic treatment; LUSC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg08200582 chr11:442649 ANO9 -0.57 -6.32 -0.33 8.2e-10 Body mass index; LUSC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg16606324 chr3:10149918 C3orf24 0.64 9.58 0.46 2.37e-19 Alzheimer's disease; LUSC cis rs834603 0.575 rs1534137 chr7:47482719 T/C cg09696706 chr7:47479511 TNS3 0.35 6.42 0.33 4.81e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs3008870 1.000 rs3008873 chr1:67425770 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.34 0.64 1.46e-40 Lymphocyte percentage of white cells; LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.27 -0.32 1.11e-9 Menopause (age at onset); LUSC trans rs9975851 0.687 rs219695 chr21:27739335 G/T cg13892514 chr2:241853394 NA 0.34 5.96 0.31 6.43e-9 Airflow obstruction; LUSC cis rs7777754 0.734 rs4947709 chr7:50672907 A/G cg18232548 chr7:50535776 DDC -0.52 -7.46 -0.38 7.59e-13 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC trans rs11992162 0.507 rs60902764 chr8:11784991 A/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.22 -0.32 1.45e-9 Monocyte count; LUSC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg21951975 chr1:209979733 IRF6 0.42 6.97 0.36 1.69e-11 Monobrow; LUSC cis rs2842992 0.747 rs4709378 chr6:160227435 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.58 7.23 0.37 3.39e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs4665630 0.708 rs4078753 chr2:23896727 C/T cg08063864 chr2:24346004 PFN4;LOC375190 -0.62 -5.72 -0.3 2.31e-8 Hypertension; LUSC cis rs1348850 0.526 rs6433672 chr2:178378175 G/T cg27490568 chr2:178487706 NA 0.4 5.84 0.3 1.22e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7582720 1.000 rs72928609 chr2:203837573 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg12564285 chr5:131593104 PDLIM4 0.39 7.47 0.38 6.96e-13 Blood metabolite levels; LUSC trans rs800082 0.734 rs1527236 chr3:144246938 G/A cg24215973 chr2:240111563 HDAC4 0.41 6.03 0.31 4.37e-9 Smoking behavior; LUSC cis rs6066835 1.000 rs73136396 chr20:47337174 T/A cg18078177 chr20:47281410 PREX1 0.75 5.78 0.3 1.68e-8 Multiple myeloma; LUSC cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 5.65 0.3 3.39e-8 Bipolar disorder; LUSC cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg12011299 chr4:100065546 ADH4 0.73 12.03 0.55 5.91e-28 Alcohol dependence; LUSC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21659725 chr3:3221576 CRBN 0.83 15.71 0.65 5.2e-42 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC trans rs74338693 0.778 rs10930189 chr2:166790998 G/A cg07963046 chr1:155764892 GON4L -0.47 -6.05 -0.31 3.97e-9 Schizophrenia; LUSC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg15557168 chr22:42548783 NA -0.44 -6.94 -0.36 2e-11 Schizophrenia; LUSC cis rs9393777 0.623 rs9358945 chr6:26472114 C/T cg12292205 chr6:26970375 C6orf41 0.6 7.21 0.37 3.75e-12 Intelligence (multi-trait analysis); LUSC cis rs2425143 1.000 rs13038622 chr20:34319343 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -6.27 -0.32 1.14e-9 Blood protein levels; LUSC cis rs10256972 0.567 rs2960850 chr7:1211649 A/G cg16145915 chr7:1198662 ZFAND2A -0.66 -12.42 -0.56 2.22e-29 Longevity;Endometriosis; LUSC cis rs17125944 0.505 rs77690283 chr14:53233320 C/G cg00686598 chr14:53173677 PSMC6 1.15 10.47 0.5 2.35e-22 Alzheimer's disease (late onset); LUSC cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg03146154 chr1:46216737 IPP 0.56 8.37 0.42 1.58e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.77e-9 Aortic root size; LUSC cis rs11630290 0.806 rs72752906 chr15:64093465 G/T cg12036633 chr15:63758958 NA -0.61 -7.08 -0.36 8.51e-12 Iris characteristics; LUSC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg05896524 chr21:47604654 C21orf56 0.52 7.8 0.39 8.06e-14 Testicular germ cell tumor; LUSC cis rs1865760 0.516 rs9393684 chr6:26075531 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 8.15 0.41 7.62e-15 Height; LUSC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11890956 chr21:40555474 PSMG1 0.91 16.32 0.67 1.89e-44 Cognitive function; LUSC cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg22782873 chr19:19639568 YJEFN3 -0.51 -6.31 -0.33 8.95e-10 Bipolar disorder; LUSC cis rs11155671 0.530 rs7768665 chr6:150208024 G/A cg09699651 chr6:150184138 LRP11 0.45 7.15 0.36 5.64e-12 Testicular germ cell tumor; LUSC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg07362569 chr17:61921086 SMARCD2 0.36 7.32 0.37 1.92e-12 Prudent dietary pattern; LUSC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg03806693 chr22:41940476 POLR3H -1.05 -15.06 -0.64 1.71e-39 Vitiligo; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25834275 chr19:3359809 NFIC 0.44 6.08 0.32 3.36e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg13531842 chr10:38383804 ZNF37A -0.48 -7.42 -0.38 9.51e-13 Extrinsic epigenetic age acceleration; LUSC cis rs56804039 1.000 rs34154295 chr8:8383477 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -6.76 -0.35 6.05e-11 Cervical cancer; LUSC cis rs9527 0.615 rs7073295 chr10:104672233 A/G cg04362960 chr10:104952993 NT5C2 0.59 9.23 0.45 3.21e-18 Arsenic metabolism; LUSC cis rs80282103 0.571 rs10047269 chr10:1103058 G/A cg08668510 chr10:1095578 IDI1 0.72 6.39 0.33 5.53e-10 Glomerular filtration rate (creatinine); LUSC cis rs7512552 0.839 rs1625468 chr1:150321486 G/A cg15654264 chr1:150340011 RPRD2 0.68 11.51 0.53 4.95e-26 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC trans rs61931739 0.658 rs4476006 chr12:34237154 A/C cg24313572 chr1:56050060 NA -0.31 -6.58 -0.34 1.83e-10 Morning vs. evening chronotype; LUSC cis rs4343996 0.967 rs1525556 chr7:3351304 G/C cg21248987 chr7:3385318 SDK1 -0.39 -6.67 -0.34 1.09e-10 Motion sickness; LUSC cis rs9920506 0.536 rs11072768 chr15:78929478 A/C cg24631222 chr15:78858424 CHRNA5 -0.56 -7.31 -0.37 2.03e-12 Post bronchodilator FEV1; LUSC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg14558114 chr2:88469736 THNSL2 0.79 7.1 0.36 7.72e-12 Plasma clusterin levels; LUSC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.46 0.59 2.79e-33 Platelet count; LUSC cis rs11997175 0.655 rs72630922 chr8:33662401 G/A ch.8.33884649F chr8:33765107 NA 0.39 5.95 0.31 6.83e-9 Body mass index; LUSC cis rs2637266 0.783 rs2588334 chr10:78518504 C/T cg18941641 chr10:78392320 NA 0.38 6.83 0.35 4.15e-11 Pulmonary function; LUSC cis rs2303282 0.839 rs9937444 chr16:56543558 A/G cg00500540 chr16:56394104 NA -0.44 -7.25 -0.37 2.9e-12 Breast cancer; LUSC cis rs977987 0.806 rs56343285 chr16:75409797 A/G cg03315344 chr16:75512273 CHST6 0.48 9.24 0.45 3.06e-18 Dupuytren's disease; LUSC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg15556689 chr8:8085844 FLJ10661 0.89 15.99 0.66 3.85e-43 Neuroticism; LUSC cis rs9399135 0.935 rs6908681 chr6:135337733 A/G cg22676075 chr6:135203613 NA 0.48 7.47 0.38 7.29e-13 Red blood cell count; LUSC cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg11843238 chr5:131593191 PDLIM4 0.32 5.75 0.3 2.05e-8 Blood metabolite levels; LUSC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg22823121 chr1:150693482 HORMAD1 0.49 7.1 0.36 7.47e-12 Melanoma; LUSC cis rs7100689 0.622 rs7090351 chr10:82142047 T/G cg00277334 chr10:82204260 NA -0.5 -7.28 -0.37 2.38e-12 Post bronchodilator FEV1; LUSC cis rs8014204 0.575 rs1045430 chr14:75130235 T/G cg06637938 chr14:75390232 RPS6KL1 0.59 9.26 0.45 2.49e-18 Caffeine consumption; LUSC cis rs2760061 0.624 rs10442629 chr1:228191070 T/A cg02753203 chr1:228287806 NA 0.9 16.76 0.68 3.56e-46 Diastolic blood pressure; LUSC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.65 14.72 0.63 3.61e-38 Hemoglobin concentration; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg25372275 chr1:161102558 DEDD 0.39 6.18 0.32 1.82e-9 Mosquito bite size; LUSC cis rs782590 0.559 rs12617719 chr2:55915826 G/C cg18811423 chr2:55921094 PNPT1 -0.79 -12.36 -0.56 3.58e-29 Metabolic syndrome; LUSC trans rs7980799 0.682 rs1601006 chr12:33629519 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.22 -0.32 1.5e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs11190604 1.000 rs11816840 chr10:102309220 G/C cg07080220 chr10:102295463 HIF1AN 0.69 9.09 0.45 8.83e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs17253792 0.822 rs76555508 chr14:56071868 A/G cg01858014 chr14:56050164 KTN1 -0.89 -7.32 -0.37 1.9e-12 Putamen volume; LUSC cis rs4356932 0.691 rs6827617 chr4:76916146 G/A cg00809888 chr4:76862425 NAAA 0.36 5.78 0.3 1.73e-8 Blood protein levels; LUSC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg06238570 chr21:40685208 BRWD1 -0.63 -10.54 -0.5 1.29e-22 Cognitive function; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02610898 chr3:128400220 NA 0.4 6.33 0.33 7.94e-10 Triglycerides; LUSC cis rs6964587 0.839 rs2049314 chr7:91464134 C/T cg22709100 chr7:91322751 NA 0.47 6.93 0.35 2.16e-11 Breast cancer; LUSC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg09034736 chr1:150693464 HORMAD1 0.41 5.72 0.3 2.38e-8 Melanoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23757506 chr17:56429622 SUPT4H1 -0.41 -6.06 -0.31 3.63e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7089973 0.624 rs17586888 chr10:116598121 T/C cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.23e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg25039879 chr17:56429692 SUPT4H1 0.74 10.11 0.48 4e-21 Cognitive test performance; LUSC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg27286337 chr10:134555280 INPP5A 0.9 11.32 0.53 2.34e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs4808199 1.000 rs4808199 chr19:19545099 C/T cg03709012 chr19:19516395 GATAD2A 1.11 14.96 0.63 4.34e-39 Nonalcoholic fatty liver disease; LUSC cis rs9388451 0.839 rs11154331 chr6:126111429 A/T cg10911889 chr6:126070802 HEY2 0.41 6.4 0.33 5.2e-10 Brugada syndrome; LUSC cis rs9361491 0.508 rs9341739 chr6:79419076 C/G cg05283184 chr6:79620031 NA -0.4 -7.01 -0.36 1.29e-11 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.01e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.25 0.52 4.23e-25 Prudent dietary pattern; LUSC cis rs11098499 0.754 rs1980025 chr4:120252806 A/G cg24375607 chr4:120327624 NA -0.74 -12.09 -0.55 3.65e-28 Corneal astigmatism; LUSC trans rs877282 1.000 rs877282 chr10:771532 G/A cg13042288 chr15:90349979 ANPEP -0.49 -6.79 -0.35 5.14e-11 Uric acid levels; LUSC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC trans rs9490306 0.941 rs2389542 chr6:121783130 A/G cg08848140 chr9:124982018 LHX6 0.34 6.08 0.32 3.36e-9 Migraine without aura;Migraine; LUSC cis rs2980439 0.607 rs2980419 chr8:8114141 A/T cg14343924 chr8:8086146 FLJ10661 0.45 6.06 0.31 3.74e-9 Neuroticism; LUSC cis rs9788682 1.000 rs7163730 chr15:78814681 A/G cg18825076 chr15:78729989 IREB2 0.46 6.34 0.33 7.33e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs10416265 0.528 rs7249097 chr19:33589144 T/C cg17764715 chr19:33622953 WDR88 0.59 8.88 0.44 4.04e-17 Bone properties (heel); LUSC cis rs728616 0.558 rs72817596 chr10:82151594 T/C cg05935833 chr10:81318306 SFTPA2 -0.44 -5.8 -0.3 1.57e-8 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9837602 1.000 rs13064704 chr3:99767541 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 5.64 0.3 3.56e-8 Breast cancer; LUSC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg22166914 chr1:53195759 ZYG11B 0.62 10.4 0.49 3.95e-22 Monocyte count; LUSC trans rs1493916 0.870 rs1389531 chr18:31386616 C/T cg15819921 chr19:927150 ARID3A -0.41 -6.17 -0.32 1.95e-9 Life satisfaction; LUSC trans rs1994135 0.630 rs11052757 chr12:33719879 A/G cg13010199 chr12:38710504 ALG10B 0.56 7.7 0.39 1.59e-13 Resting heart rate; LUSC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg09650180 chr20:62225654 GMEB2 0.66 9.86 0.47 2.7e-20 Glioblastoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03067192 chr7:72300134 SBDSP;TYW1B -0.42 -6.32 -0.33 8.29e-10 Electrocardiographic conduction measures; LUSC trans rs2055729 0.528 rs11987861 chr8:9742206 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -6.62 -0.34 1.45e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs17253792 0.822 rs79618862 chr14:56093971 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC trans rs1268789 0.545 rs1496584 chr4:79375590 G/A cg06112894 chr8:141469983 TRAPPC9 0.23 6.0 0.31 5.11e-9 Hair shape;Hair morphology; LUSC cis rs7584330 0.504 rs11883500 chr2:238434434 C/T cg16989719 chr2:238392110 NA -0.4 -5.65 -0.3 3.42e-8 Prostate cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05086178 chr16:2588345 PDPK1 0.78 6.37 0.33 6.17e-10 Cognitive performance; LUSC trans rs7769051 1.000 rs9493446 chr6:133125643 C/T cg27275811 chr11:74457193 NA -0.64 -6.22 -0.32 1.51e-9 Type 2 diabetes nephropathy; LUSC cis rs7312933 0.558 rs11181463 chr12:42763636 C/T cg01256987 chr12:42539512 GXYLT1 -0.39 -7.06 -0.36 9.87e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs11098499 1.000 rs12506395 chr4:120185094 C/T cg24375607 chr4:120327624 NA 0.75 11.11 0.52 1.25e-24 Corneal astigmatism; LUSC cis rs10751667 0.857 rs6597952 chr11:991109 C/G cg01483505 chr11:975446 AP2A2 0.41 5.7 0.3 2.58e-8 Alzheimer's disease (late onset); LUSC cis rs1371867 0.846 rs1788180 chr8:101333368 A/G cg06636551 chr8:101224915 SPAG1 -0.38 -7.13 -0.36 6.31e-12 Atrioventricular conduction; LUSC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg08470875 chr2:26401718 FAM59B -0.66 -8.89 -0.44 3.88e-17 Gut microbiome composition (summer); LUSC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg05234568 chr11:5960015 NA -0.62 -10.44 -0.5 2.95e-22 DNA methylation (variation); LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.62 -0.5 6.83e-23 Alzheimer's disease; LUSC cis rs9517313 0.565 rs9556978 chr13:99234648 G/A cg07423050 chr13:99094983 FARP1 -0.51 -9.26 -0.45 2.63e-18 Neuroticism; LUSC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg16325326 chr1:53192061 ZYG11B -0.89 -16.56 -0.67 2.26e-45 Monocyte count; LUSC cis rs4363385 0.782 rs310105 chr1:153022253 A/G cg00922841 chr1:152955080 SPRR1A -0.43 -7.44 -0.38 8.47e-13 Inflammatory skin disease; LUSC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg17264618 chr3:40429014 ENTPD3 0.35 7.08 0.36 8.58e-12 Renal cell carcinoma; LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg23758822 chr17:41437982 NA 1.04 20.11 0.74 1.65e-59 Menopause (age at onset); LUSC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg14895029 chr7:2775587 GNA12 -0.37 -6.05 -0.31 3.78e-9 Height; LUSC cis rs1577917 1.000 rs884841 chr6:86680300 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.27 -0.41 3.27e-15 Response to antipsychotic treatment; LUSC cis rs1729951 0.575 rs10935214 chr3:136693485 G/A cg21827317 chr3:136751795 NA 0.39 6.93 0.35 2.24e-11 Neuroticism; LUSC cis rs921968 0.565 rs3731876 chr2:219602819 G/A cg02176678 chr2:219576539 TTLL4 -0.58 -10.22 -0.49 1.62e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs9457247 0.756 rs1811123 chr6:167403443 T/C cg23791538 chr6:167370224 RNASET2 -0.43 -6.91 -0.35 2.4e-11 Crohn's disease; LUSC cis rs2692947 0.637 rs1168967 chr2:96826016 A/G cg22654517 chr2:96458247 NA 0.35 7.03 0.36 1.16e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7572644 0.640 rs9678430 chr2:28057129 G/C cg27432699 chr2:27873401 GPN1 0.52 6.95 0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.47 -0.38 7.13e-13 Aortic root size; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg25894440 chr7:65020034 NA -0.37 -5.94 -0.31 7.08e-9 Calcium levels; LUSC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg00024416 chr22:24240387 NA -0.35 -6.17 -0.32 1.98e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9469578 0.901 rs16869459 chr6:33714908 G/A cg18708504 chr6:33715942 IP6K3 0.72 9.18 0.45 4.73e-18 Phosphorus levels; LUSC cis rs3736594 0.559 rs62141292 chr2:27784300 A/C cg27432699 chr2:27873401 GPN1 0.66 8.77 0.43 9.35e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs3806843 1.000 rs2240695 chr5:140168151 G/T cg26395211 chr5:140044315 WDR55 -0.37 -5.77 -0.3 1.78e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs9929218 0.539 rs1125557 chr16:68809599 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.97 19.26 0.73 3.88e-56 Colorectal cancer; LUSC cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg11984989 chr7:158649758 WDR60 -0.98 -16.39 -0.67 9.96e-45 Height; LUSC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg00033643 chr7:134001901 SLC35B4 0.45 6.91 0.35 2.52e-11 Mean platelet volume; LUSC trans rs1493916 0.967 rs9953765 chr18:31399464 A/G cg15819921 chr19:927150 ARID3A -0.43 -6.41 -0.33 5.02e-10 Life satisfaction; LUSC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04873961 chr2:70418194 C2orf42 -0.42 -6.08 -0.32 3.28e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1178968 1.000 rs917247 chr7:72761420 C/T cg25889504 chr7:72793014 NA -0.52 -6.9 -0.35 2.57e-11 Triglyceride levels; LUSC cis rs2073300 0.609 rs56094936 chr20:23401586 G/A cg09953122 chr20:23471693 CST8 -0.66 -5.72 -0.3 2.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs28595532 0.920 rs17325192 chr4:119780345 A/G cg02775129 chr4:119771670 NA 0.73 7.06 0.36 9.55e-12 Cannabis dependence symptom count; LUSC cis rs748404 0.697 rs475227 chr15:43546446 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.49 7.79 0.39 8.69e-14 Lung cancer; LUSC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg06212747 chr3:49208901 KLHDC8B 0.6 8.52 0.42 5.58e-16 Menarche (age at onset); LUSC cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg13256891 chr4:100009986 ADH5 0.51 6.96 0.36 1.79e-11 Smoking initiation; LUSC cis rs2455601 0.744 rs2568085 chr11:8975748 G/T cg09997546 chr11:8931473 C11orf17;ST5 0.38 7.12 0.36 6.83e-12 Schizophrenia; LUSC cis rs2857078 0.627 rs1476512 chr17:42330122 C/T cg13607699 chr17:42295918 UBTF -0.41 -6.52 -0.34 2.67e-10 Red cell distribution width;Reticulocyte count; LUSC cis rs9287719 0.649 rs10929684 chr2:10732224 C/T cg00105475 chr2:10696890 NA -0.34 -5.68 -0.3 2.99e-8 Prostate cancer; LUSC cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg09184832 chr6:79620586 NA -0.44 -7.18 -0.37 4.63e-12 Intelligence (multi-trait analysis); LUSC cis rs17095355 1.000 rs12571674 chr10:111717608 C/T cg00817464 chr10:111662876 XPNPEP1 0.63 7.38 0.37 1.3e-12 Biliary atresia; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg10802521 chr3:52805072 NEK4 0.56 8.92 0.44 3.08e-17 Bipolar disorder; LUSC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.08 -0.32 3.35e-9 Major depressive disorder; LUSC cis rs10876993 0.890 rs12302350 chr12:58062589 T/G cg18357645 chr12:58087776 OS9 0.54 8.11 0.41 9.5e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs6845621 0.901 rs7697704 chr4:18922478 C/G cg12196642 chr4:18937545 NA -0.34 -6.5 -0.33 2.97e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg12756686 chr19:29218302 NA 0.58 6.53 0.34 2.47e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg02117656 chr17:79614917 TSPAN10 0.31 5.77 0.3 1.85e-8 Eye color traits; LUSC cis rs10782582 0.609 rs5745430 chr1:76332994 C/T cg10523679 chr1:76189770 ACADM -0.48 -6.83 -0.35 4.02e-11 Daytime sleep phenotypes; LUSC cis rs975210 0.656 rs16954106 chr15:70357918 C/T cg01666796 chr15:70364327 TLE3 -0.71 -8.25 -0.41 3.78e-15 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; LUSC cis rs9467773 0.620 rs2101581 chr6:26622769 G/T cg09904177 chr6:26538194 HMGN4 0.66 11.73 0.54 7.4e-27 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.510 rs1500937 chr1:153045483 G/C cg00922841 chr1:152955080 SPRR1A -0.38 -6.31 -0.33 8.76e-10 Inflammatory skin disease; LUSC cis rs763121 0.853 rs5750622 chr22:38956464 C/G cg14440974 chr22:39074834 NA -0.38 -6.21 -0.32 1.55e-9 Menopause (age at onset); LUSC cis rs9399135 0.967 rs9376075 chr6:135296963 A/G cg24558204 chr6:135376177 HBS1L 0.58 9.0 0.44 1.69e-17 Red blood cell count; LUSC cis rs7582720 0.561 rs114407963 chr2:204154677 A/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 7.79 0.39 8.3e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg12365402 chr11:9010492 NRIP3 0.42 8.16 0.41 7e-15 Hemoglobin concentration; LUSC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg01448562 chr3:133502909 NA -0.58 -8.7 -0.43 1.48e-16 Iron status biomarkers; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg03372779 chr16:2069785 NPW 0.65 5.96 0.31 6.45e-9 Cognitive performance; LUSC cis rs240764 0.658 rs9404054 chr6:101256597 A/G cg09795085 chr6:101329169 ASCC3 -0.45 -6.47 -0.33 3.57e-10 Neuroticism; LUSC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18099408 chr3:52552593 STAB1 -0.42 -7.37 -0.37 1.34e-12 Electroencephalogram traits; LUSC cis rs12464483 0.591 rs4952171 chr2:30886903 G/A cg17749961 chr2:30669863 LCLAT1 0.7 8.04 0.4 1.57e-14 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg22920501 chr2:26401640 FAM59B -0.74 -10.59 -0.5 8.59e-23 Gut microbiome composition (summer); LUSC cis rs6977660 1.000 rs5017196 chr7:19819983 T/C cg05791153 chr7:19748676 TWISTNB 0.53 5.81 0.3 1.42e-8 Thyroid stimulating hormone; LUSC cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg26408565 chr15:76604113 ETFA -0.42 -6.78 -0.35 5.53e-11 Blood metabolite levels; LUSC cis rs17685 0.725 rs4476928 chr7:75642107 C/A cg16489192 chr7:75678113 MDH2;STYXL1 0.51 7.86 0.4 5.35e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg09021430 chr5:549028 NA -0.53 -7.36 -0.37 1.43e-12 Obesity-related traits; LUSC cis rs11630290 0.736 rs2197259 chr15:64154156 T/C cg12036633 chr15:63758958 NA 0.59 6.36 0.33 6.51e-10 Iris characteristics; LUSC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg01475377 chr6:109611718 NA -0.46 -8.44 -0.42 1e-15 Reticulocyte fraction of red cells; LUSC cis rs7119038 0.818 rs11217033 chr11:118673706 T/C cg19308663 chr11:118741387 NA 0.36 6.47 0.33 3.49e-10 Sjögren's syndrome; LUSC cis rs8062405 1.000 rs7205323 chr16:28865892 C/T cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs28719689 0.655 rs58892423 chr8:1276014 A/C cg22761795 chr8:1265118 NA 0.59 6.78 0.35 5.61e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs6754311 0.731 rs13404551 chr2:136721995 T/C cg07169764 chr2:136633963 MCM6 0.53 7.38 0.37 1.25e-12 Mosquito bite size; LUSC cis rs9359856 0.564 rs17506403 chr6:90499059 C/G cg13799429 chr6:90582589 CASP8AP2 -0.8 -7.93 -0.4 3.22e-14 Bipolar disorder; LUSC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg24562669 chr7:97807699 LMTK2 -0.35 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.13 -0.45 6.73e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs3812762 0.917 rs11042066 chr11:8809560 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.4 6.83 0.35 3.98e-11 Hypospadias; LUSC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.38 6.02 0.31 4.54e-9 Electroencephalogram traits; LUSC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.05 0.36 1.01e-11 Tonsillectomy; LUSC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.7 0.34 8.84e-11 Lung cancer; LUSC cis rs727505 0.866 rs73227503 chr7:124721044 A/G cg23710748 chr7:124431027 NA -0.4 -6.96 -0.36 1.79e-11 Lewy body disease; LUSC cis rs68170813 0.559 rs76299183 chr7:106904859 A/G cg02696742 chr7:106810147 HBP1 -0.65 -10.04 -0.48 6.87e-21 Coronary artery disease; LUSC cis rs12618769 0.625 rs56232707 chr2:99032298 G/A cg10123293 chr2:99228465 UNC50 0.47 7.9 0.4 3.99e-14 Bipolar disorder; LUSC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg23283495 chr1:209979779 IRF6 0.63 7.97 0.4 2.61e-14 Cleft lip with or without cleft palate; LUSC cis rs7582180 0.629 rs11686880 chr2:100956229 C/T cg08017756 chr2:100939284 LONRF2 -0.46 -8.51 -0.42 5.85e-16 Intelligence (multi-trait analysis); LUSC cis rs12476592 0.602 rs262538 chr2:63908025 A/T cg10828910 chr2:63850056 LOC388955 -0.5 -5.79 -0.3 1.65e-8 Childhood ear infection; LUSC cis rs3126085 0.935 rs1496045 chr1:152184704 C/T cg26876637 chr1:152193138 HRNR 0.42 5.96 0.31 6.41e-9 Atopic dermatitis; LUSC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg01416388 chr22:39784598 NA 0.41 6.76 0.35 6.28e-11 IgG glycosylation; LUSC cis rs7615952 0.866 rs1976459 chr3:125647486 A/T cg02807482 chr3:125708958 NA -0.49 -5.79 -0.3 1.66e-8 Blood pressure (smoking interaction); LUSC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11890956 chr21:40555474 PSMG1 -0.85 -14.81 -0.63 1.72e-38 Cognitive function; LUSC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg23711669 chr6:146136114 FBXO30 0.91 17.06 0.68 2.16e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.23 0.32 1.42e-9 Height; LUSC cis rs1559088 0.948 rs12610071 chr19:33582687 A/C cg17764715 chr19:33622953 WDR88 0.59 8.14 0.41 7.89e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9534288 0.830 rs1126363 chr13:46633459 C/T cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC cis rs9467773 0.595 rs2237236 chr6:26451553 A/G cg05738196 chr6:26577821 NA -0.54 -7.77 -0.39 9.53e-14 Intelligence (multi-trait analysis); LUSC cis rs9815354 0.638 rs113712591 chr3:42050624 C/T cg03022575 chr3:42003672 ULK4 0.78 7.85 0.39 5.64e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs877282 0.891 rs11253393 chr10:788824 G/T cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg13206674 chr6:150067644 NUP43 0.44 6.74 0.35 6.76e-11 Testicular germ cell tumor; LUSC cis rs3733418 0.929 rs4691138 chr4:165908641 A/G cg11630554 chr4:165878136 TRIM61;C4orf39 -0.51 -5.83 -0.3 1.34e-8 Obesity-related traits; LUSC cis rs427394 0.802 rs274718 chr5:6720988 G/T cg10857441 chr5:6722123 POLS -0.45 -8.98 -0.44 2.05e-17 Menopause (age at onset); LUSC cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg00071950 chr4:10020882 SLC2A9 0.66 11.15 0.52 9.54e-25 Bone mineral density; LUSC cis rs11585357 0.895 rs72646798 chr1:17614422 C/T cg08277548 chr1:17600880 PADI3 -0.64 -6.62 -0.34 1.42e-10 Hair shape; LUSC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg07362569 chr17:61921086 SMARCD2 0.38 7.81 0.39 7.4e-14 Prudent dietary pattern; LUSC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.43 0.38 8.9e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6089584 0.566 rs6061964 chr20:60607536 G/A cg06108461 chr20:60628389 TAF4 -0.74 -12.01 -0.55 6.98e-28 Body mass index; LUSC cis rs11098499 0.789 rs1980024 chr4:120253047 C/T cg09307838 chr4:120376055 NA 0.7 10.67 0.5 4.72e-23 Corneal astigmatism; LUSC cis rs17433780 0.504 rs1409150 chr1:89473175 A/G cg09516651 chr1:89888402 LOC400759 0.42 7.48 0.38 6.69e-13 Carotid intima media thickness; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16711083 chr3:125239198 SNX4 -0.43 -6.24 -0.32 1.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4319547 0.656 rs10161534 chr12:122873864 T/C cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.23 -0.41 4.31e-15 Body mass index; LUSC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg06454157 chr6:167490870 NA 0.25 6.15 0.32 2.18e-9 Crohn's disease; LUSC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.78 10.04 0.48 6.49e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9611565 0.506 rs4822020 chr22:41700203 C/T cg03806693 chr22:41940476 POLR3H -0.63 -9.21 -0.45 3.59e-18 Vitiligo; LUSC cis rs1403694 0.515 rs5030058 chr3:186452415 T/G cg12454167 chr3:186435060 KNG1 0.29 7.45 0.38 7.85e-13 Blood protein levels; LUSC cis rs11190604 1.000 rs12219789 chr10:102213778 A/G cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12210905 0.925 rs7740207 chr6:27001623 C/T cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.97 -0.31 5.9e-9 Hip circumference adjusted for BMI; LUSC cis rs13242816 1.000 rs56275709 chr7:116108489 A/G cg16553024 chr7:116138462 CAV2 -0.54 -5.92 -0.31 7.84e-9 P wave duration; LUSC cis rs6723226 0.803 rs176415 chr2:32649778 G/A cg02381751 chr2:32503542 YIPF4 -0.61 -9.34 -0.46 1.35e-18 Intelligence (multi-trait analysis); LUSC cis rs9388451 0.839 rs1811852 chr6:126071575 G/C cg05901451 chr6:126070800 HEY2 -0.96 -18.94 -0.72 7.19e-55 Brugada syndrome; LUSC cis rs11992162 0.967 rs10088415 chr8:11830825 A/G cg21775007 chr8:11205619 TDH -0.52 -7.4 -0.38 1.13e-12 Monocyte count; LUSC cis rs6722750 1.000 rs35573827 chr2:64394433 C/G cg22352474 chr2:64371530 PELI1 0.57 8.61 0.43 2.9e-16 Neuroticism; LUSC cis rs11958404 0.932 rs76601259 chr5:157430337 C/T cg05962755 chr5:157440814 NA 0.55 6.27 0.32 1.11e-9 IgG glycosylation; LUSC trans rs2204008 0.522 rs12370263 chr12:38113311 A/G cg06521331 chr12:34319734 NA -0.42 -6.35 -0.33 7.02e-10 Bladder cancer; LUSC cis rs929354 1.000 rs1182377 chr7:157048403 T/C cg05182265 chr7:156933206 UBE3C 0.45 6.9 0.35 2.58e-11 Body mass index; LUSC cis rs9788682 0.747 rs12910984 chr15:78891627 G/A cg24631222 chr15:78858424 CHRNA5 -0.67 -9.13 -0.45 6.9e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2845885 1.000 rs11231698 chr11:63877163 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.81 7.11 0.36 6.94e-12 Body mass index; LUSC cis rs68170813 0.641 rs4730248 chr7:107125939 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.44 -5.9 -0.31 8.81e-9 Coronary artery disease; LUSC cis rs6456156 0.524 rs6932740 chr6:167466439 G/A cg25258033 chr6:167368657 RNASET2 0.36 5.68 0.3 2.88e-8 Primary biliary cholangitis; LUSC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg26597838 chr10:835615 NA 0.99 13.84 0.6 9.21e-35 Eosinophil percentage of granulocytes; LUSC cis rs7202877 0.610 rs468079 chr16:75428474 G/A cg03315344 chr16:75512273 CHST6 -0.41 -6.1 -0.32 3e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs72949976 0.864 rs13389834 chr2:214025112 G/A cg08319019 chr2:214017104 IKZF2 -0.65 -10.19 -0.49 2.04e-21 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs2130392 0.961 rs2696035 chr4:185612953 A/G cg04058563 chr4:185651563 MLF1IP 0.39 6.37 0.33 6.28e-10 Kawasaki disease; LUSC cis rs8060686 0.545 rs10500543 chr16:68281311 T/C cg09835421 chr16:68378352 PRMT7 -0.67 -7.02 -0.36 1.28e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs12618769 0.652 rs17033813 chr2:99196483 A/G cg10123293 chr2:99228465 UNC50 -0.45 -7.2 -0.37 3.9e-12 Bipolar disorder; LUSC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg06618935 chr21:46677482 NA -0.37 -7.58 -0.38 3.42e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg06008330 chr7:65541103 ASL 0.39 6.06 0.31 3.65e-9 Aortic root size; LUSC cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg21535247 chr6:8435926 SLC35B3 0.59 9.1 0.45 8.56e-18 Motion sickness; LUSC cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.02e-28 Motion sickness; LUSC cis rs854765 0.583 rs6502619 chr17:17779704 C/G cg04398451 chr17:18023971 MYO15A 0.44 6.96 0.36 1.79e-11 Total body bone mineral density; LUSC cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg07274523 chr3:49395745 GPX1 0.68 10.46 0.5 2.38e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2294693 0.530 rs2073016 chr6:41020922 T/C cg14769373 chr6:40998127 UNC5CL -0.47 -5.86 -0.31 1.08e-8 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg25019033 chr10:957182 NA -0.52 -7.2 -0.37 3.99e-12 Eosinophil percentage of granulocytes; LUSC cis rs10191773 0.589 rs11676628 chr2:112953355 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 0.49 6.1 0.32 3.02e-9 Yeast infection; LUSC cis rs713477 0.967 rs2152975 chr14:55907919 C/T cg13175173 chr14:55914753 NA -0.32 -6.67 -0.34 1.07e-10 Pediatric bone mineral content (femoral neck); LUSC trans rs12579753 1.000 rs12579753 chr12:82219376 C/T cg07923666 chr12:49932857 KCNH3 -0.52 -6.36 -0.33 6.46e-10 Resting heart rate; LUSC cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.33 0.41 2.14e-15 Height; LUSC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs68170813 0.605 rs10464620 chr7:107135653 A/G cg02696742 chr7:106810147 HBP1 0.66 9.78 0.47 4.89e-20 Coronary artery disease; LUSC cis rs12541635 0.677 rs11781234 chr8:107012342 G/T cg10147462 chr8:107024639 NA 0.68 14.28 0.62 1.94e-36 Age of smoking initiation; LUSC cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg01119278 chr6:110721349 DDO 0.43 7.73 0.39 1.27e-13 Platelet distribution width; LUSC cis rs713587 0.525 rs1541984 chr2:25082414 G/A cg15423357 chr2:25149977 NA 0.35 6.78 0.35 5.59e-11 Body mass index in non-asthmatics; LUSC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.43e-59 Height; LUSC cis rs2273669 0.667 rs78383792 chr6:109312498 A/G cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg12379764 chr21:47803548 PCNT -0.41 -5.73 -0.3 2.26e-8 Testicular germ cell tumor; LUSC cis rs7264396 0.635 rs2064724 chr20:34522520 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.02 -0.44 1.54e-17 Total cholesterol levels; LUSC cis rs1957429 0.614 rs7144637 chr14:65349709 A/G cg23373153 chr14:65346875 NA -1.03 -9.4 -0.46 8.72e-19 Pediatric areal bone mineral density (radius); LUSC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg18099408 chr3:52552593 STAB1 -0.41 -6.99 -0.36 1.46e-11 Bipolar disorder; LUSC cis rs453301 0.598 rs2921383 chr8:8892221 C/T cg15556689 chr8:8085844 FLJ10661 0.69 11.07 0.52 1.76e-24 Joint mobility (Beighton score); LUSC cis rs9296092 0.538 rs5000098 chr6:33519231 T/G cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.59e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03934478 chr11:495069 RNH1 0.86 9.38 0.46 1.06e-18 Body mass index; LUSC cis rs1355223 0.583 rs2915179 chr11:34871943 C/T cg24088639 chr11:34937564 PDHX;APIP -0.46 -6.77 -0.35 5.66e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11098499 0.954 rs13133522 chr4:120324424 A/T cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs7524258 0.868 rs4908610 chr1:7311260 C/A cg07173049 chr1:7289937 CAMTA1 0.33 6.61 0.34 1.57e-10 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg22903657 chr4:1355424 KIAA1530 -0.36 -5.98 -0.31 5.84e-9 Longevity; LUSC cis rs4919694 1.000 rs35159404 chr10:104805610 C/A cg04362960 chr10:104952993 NT5C2 1.18 13.93 0.61 4.45e-35 Arsenic metabolism; LUSC cis rs12908161 1.000 rs12905057 chr15:85210765 A/G cg11189052 chr15:85197271 WDR73 0.49 6.03 0.31 4.45e-9 Schizophrenia; LUSC cis rs10761482 0.769 rs4442496 chr10:62101371 T/C cg18175470 chr10:62150864 ANK3 -0.52 -7.35 -0.37 1.56e-12 Schizophrenia; LUSC cis rs3020736 0.519 rs5996116 chr22:42517492 G/A cg15557168 chr22:42548783 NA 0.46 6.98 0.36 1.62e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs41271473 0.526 rs12094319 chr1:228717836 G/C cg16512390 chr1:228756714 NA 0.7 8.82 0.43 6.67e-17 Chronic lymphocytic leukemia; LUSC trans rs9329221 0.527 rs10903328 chr8:10332167 G/C cg06636001 chr8:8085503 FLJ10661 0.48 6.68 0.34 1.02e-10 Neuroticism; LUSC cis rs9549367 0.756 rs9603814 chr13:113900782 C/T cg00898013 chr13:113819073 PROZ 0.52 7.8 0.39 7.74e-14 Platelet distribution width; LUSC cis rs4746818 0.711 rs4745976 chr10:70845181 A/G cg11621586 chr10:70884670 VPS26A 0.71 7.42 0.38 1.01e-12 Left atrial antero-posterior diameter; LUSC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg12463550 chr7:65579703 CRCP -0.51 -7.38 -0.37 1.3e-12 Aortic root size; LUSC cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg05340658 chr4:99064831 C4orf37 0.57 9.54 0.46 3.03e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2762353 0.505 rs2096386 chr6:25787817 C/T cg12310025 chr6:25882481 NA 0.34 5.86 0.31 1.1e-8 Blood metabolite levels; LUSC cis rs9378688 0.929 rs9392373 chr6:2210006 T/A cg12303981 chr6:2244766 GMDS -0.51 -6.34 -0.33 7.53e-10 Caudate nucleus volume; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.49 0.42 6.97e-16 Prudent dietary pattern; LUSC cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg05855489 chr10:104503620 C10orf26 0.59 9.51 0.46 3.79e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2732480 0.500 rs11168468 chr12:48612465 C/T cg04545296 chr12:48745243 ZNF641 0.33 6.22 0.32 1.5e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg18350739 chr11:68623251 NA -0.38 -6.71 -0.34 8.13e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg11764359 chr7:65958608 NA 0.71 10.7 0.51 3.64e-23 Aortic root size; LUSC cis rs7605827 0.897 rs4668908 chr2:15589290 G/T cg19274914 chr2:15703543 NA 0.45 8.5 0.42 6.41e-16 Educational attainment (years of education); LUSC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg01368799 chr11:117014884 PAFAH1B2 0.5 6.68 0.34 9.92e-11 Blood protein levels; LUSC cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg23625390 chr15:77176239 SCAPER 0.52 7.98 0.4 2.38e-14 Blood metabolite levels; LUSC cis rs2219968 0.798 rs57034374 chr8:78911919 T/C cg00738934 chr8:78996279 NA -0.41 -7.37 -0.37 1.35e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg05347473 chr6:146136440 FBXO30 0.46 7.96 0.4 2.72e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs4074961 0.692 rs11264075 chr1:38083941 C/G cg02930200 chr1:38022384 DNALI1 0.29 5.92 0.31 7.91e-9 Axial length; LUSC trans rs867371 0.502 rs2047679 chr15:82531881 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.35 -0.33 7.13e-10 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg04267008 chr7:1944627 MAD1L1 -0.55 -8.24 -0.41 4.07e-15 Bipolar disorder and schizophrenia; LUSC cis rs9469578 0.579 rs77528762 chr6:33683068 A/T cg18708504 chr6:33715942 IP6K3 0.67 6.33 0.33 8e-10 Phosphorus levels; LUSC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg23283495 chr1:209979779 IRF6 0.73 9.34 0.46 1.37e-18 Cleft lip with or without cleft palate; LUSC cis rs2762353 0.935 rs3799340 chr6:25762646 C/T cg03264133 chr6:25882463 NA 0.43 7.34 0.37 1.66e-12 Blood metabolite levels; LUSC trans rs561341 0.830 rs7218801 chr17:30217778 A/G cg27661571 chr11:113659931 NA 0.58 6.35 0.33 7.05e-10 Hip circumference adjusted for BMI; LUSC cis rs12368653 0.534 rs923828 chr12:58015494 G/A cg12615879 chr12:58013172 SLC26A10 0.43 10.27 0.49 1.07e-21 Multiple sclerosis; LUSC cis rs2180341 0.618 rs12210968 chr6:127596985 A/G cg27446573 chr6:127587934 RNF146 0.64 10.32 0.49 7.57e-22 Breast cancer; LUSC cis rs11250097 0.549 rs11778177 chr8:11310362 C/T cg27411982 chr8:10470053 RP1L1 -0.42 -6.03 -0.31 4.46e-9 Neuroticism; LUSC cis rs4845570 0.920 rs1196456 chr1:151737349 T/A cg07092448 chr1:151763213 TDRKH 1.25 15.93 0.66 6.67e-43 Coronary artery disease; LUSC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg22166914 chr1:53195759 ZYG11B -0.71 -12.23 -0.56 1.11e-28 Monocyte count; LUSC cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg17143192 chr8:8559678 CLDN23 0.64 9.02 0.44 1.47e-17 Obesity-related traits; LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.67 0.39 1.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs59104589 0.617 rs12233133 chr2:242256812 G/C cg14842376 chr2:242211374 HDLBP 0.58 6.49 0.33 3.17e-10 Fibrinogen levels; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg00431813 chr7:1051703 C7orf50 -0.39 -6.03 -0.31 4.28e-9 Longevity;Endometriosis; LUSC cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.76 0.84 8.98e-89 Chronic sinus infection; LUSC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg22834771 chr12:69754056 YEATS4 -0.56 -8.42 -0.42 1.11e-15 Cerebrospinal fluid biomarker levels; LUSC cis rs71403859 0.570 rs76231867 chr16:71449926 G/A cg08717414 chr16:71523259 ZNF19 -0.62 -7.03 -0.36 1.14e-11 Post bronchodilator FEV1; LUSC trans rs9329221 0.537 rs6601415 chr8:9976805 C/A cg15556689 chr8:8085844 FLJ10661 0.53 7.96 0.4 2.74e-14 Neuroticism; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg20887711 chr4:1340912 KIAA1530 0.69 11.25 0.52 4.11e-25 Longevity; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg03579872 chr1:53393473 SCP2 -0.39 -5.97 -0.31 6.13e-9 Monocyte count; LUSC cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg24642439 chr20:33292090 TP53INP2 0.55 8.2 0.41 5.38e-15 Height; LUSC cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.51 7.83 0.39 6.43e-14 Menarche (age at onset); LUSC cis rs10992471 0.603 rs7873397 chr9:95205928 G/C cg14631576 chr9:95140430 CENPP -0.35 -6.46 -0.33 3.65e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2739330 0.685 rs4822453 chr22:24254862 G/T cg25703541 chr22:24373054 LOC391322 -0.92 -16.03 -0.66 2.66e-43 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7953508 0.619 rs11107114 chr12:93972927 G/A cg18151635 chr12:93972918 NA -0.62 -8.8 -0.43 7.38e-17 Pubertal anthropometrics; LUSC cis rs131777 0.577 rs5770928 chr22:51029091 G/C cg00083937 chr22:51039805 MAPK8IP2 0.5 8.34 0.42 1.99e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg02428538 chr16:24856791 SLC5A11 -0.52 -5.89 -0.31 9.52e-9 Intelligence (multi-trait analysis); LUSC cis rs66887589 0.934 rs12648182 chr4:120503891 T/A cg24375607 chr4:120327624 NA -0.46 -7.11 -0.36 7.19e-12 Diastolic blood pressure; LUSC cis rs35883536 0.528 rs1542837 chr1:101029768 T/C cg06223162 chr1:101003688 GPR88 0.46 8.57 0.42 3.92e-16 Monocyte count; LUSC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg02569458 chr12:86230093 RASSF9 0.52 8.57 0.42 3.81e-16 Major depressive disorder; LUSC cis rs9457247 0.756 rs2345572 chr6:167403441 A/T cg25258033 chr6:167368657 RNASET2 0.48 7.83 0.39 6.61e-14 Crohn's disease; LUSC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg19077165 chr18:44547161 KATNAL2 -0.39 -5.66 -0.3 3.22e-8 Personality dimensions; LUSC cis rs4662945 0.603 rs10496678 chr2:130262209 C/T cg05962382 chr2:130345044 NA -0.39 -6.85 -0.35 3.57e-11 Response to cytidine analogues (gemcitabine); LUSC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg06263672 chr7:65235340 NA 0.47 6.75 0.35 6.73e-11 Calcium levels; LUSC cis rs6582618 1 rs6582618 chr12:38726137 A/G cg13010199 chr12:38710504 ALG10B 0.47 7.14 0.36 5.79e-12 Morning vs. evening chronotype; LUSC cis rs4820539 1.000 rs5759598 chr22:23480962 T/G cg14186256 chr22:23484241 RTDR1 0.91 16.66 0.67 9.06e-46 Bone mineral density; LUSC cis rs9612 1.000 rs346534 chr19:44250831 A/G cg08581076 chr19:44259116 C19orf61 0.54 6.71 0.34 8.5e-11 Exhaled nitric oxide output; LUSC cis rs10193935 0.901 rs222478 chr2:42656919 G/T cg27598129 chr2:42591480 NA -0.56 -7.74 -0.39 1.16e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.779 rs7699346 chr4:120310542 C/T cg24375607 chr4:120327624 NA 0.76 11.15 0.52 9.61e-25 Corneal astigmatism; LUSC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.21 -0.41 4.88e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11890956 chr21:40555474 PSMG1 -0.75 -11.65 -0.54 1.47e-26 Menarche (age at onset); LUSC cis rs6840360 0.615 rs12647586 chr4:152607568 G/C cg22705602 chr4:152727874 NA -0.37 -7.93 -0.4 3.32e-14 Intelligence (multi-trait analysis); LUSC cis rs67366981 1.000 rs2287383 chr14:77713036 C/G cg22824376 chr14:77648248 TMEM63C 0.65 6.19 0.32 1.75e-9 Obsessive-compulsive symptoms; LUSC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19783675 chr5:132362235 ZCCHC10 -0.45 -6.79 -0.35 5.2e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17270561 0.636 rs2070642 chr6:25831212 G/A cg16482183 chr6:26056742 HIST1H1C 0.59 8.36 0.42 1.71e-15 Iron status biomarkers; LUSC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg11344533 chr11:111475393 SIK2 -0.45 -6.14 -0.32 2.31e-9 Primary sclerosing cholangitis; LUSC trans rs8060598 0.866 rs3135499 chr16:50766127 G/T cg25118631 chr4:120206103 USP53 -0.39 -5.96 -0.31 6.24e-9 Leprosy; LUSC cis rs137603 0.623 rs470075 chr22:39686806 G/A cg17798944 chr22:39715225 SNORD43;RPL3 -0.54 -8.62 -0.43 2.69e-16 Primary biliary cholangitis; LUSC cis rs6938 0.618 rs11072514 chr15:75221865 T/A cg10253484 chr15:75165896 SCAMP2 -0.45 -6.43 -0.33 4.29e-10 Breast cancer; LUSC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.53 0.38 4.76e-13 Parkinson's disease; LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg04267008 chr7:1944627 MAD1L1 0.56 8.33 0.41 2.05e-15 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.53 -7.75 -0.39 1.12e-13 Gut microbiome composition (summer); LUSC cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg00071950 chr4:10020882 SLC2A9 0.55 8.93 0.44 2.81e-17 Bone mineral density; LUSC cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg04727924 chr7:799746 HEATR2 -0.54 -6.78 -0.35 5.6e-11 Cerebrospinal P-tau181p levels; LUSC cis rs2836633 0.931 rs2836635 chr21:40069850 A/G cg05519781 chr21:40033154 ERG 0.62 9.95 0.48 1.32e-20 Coronary artery disease; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg23102388 chr7:1867652 MAD1L1 0.31 5.82 0.3 1.35e-8 Bipolar disorder and schizophrenia; LUSC cis rs6547741 0.816 rs10201652 chr2:27874332 A/C cg27432699 chr2:27873401 GPN1 -0.88 -17.51 -0.69 3.63e-49 Oral cavity cancer; LUSC cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12791010 chr2:190305806 WDR75 -0.41 -6.3 -0.33 9.31e-10 Electrocardiographic conduction measures; LUSC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg03806693 chr22:41940476 POLR3H -0.99 -14.12 -0.61 8.14e-36 Vitiligo; LUSC cis rs12586317 0.531 rs60049741 chr14:35719842 G/A cg05294307 chr14:35346193 BAZ1A -0.39 -5.67 -0.3 3.16e-8 Psoriasis; LUSC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg05863683 chr7:1912471 MAD1L1 0.3 5.77 0.3 1.83e-8 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg24562669 chr7:97807699 LMTK2 0.34 5.97 0.31 6.16e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg04450456 chr4:17643702 FAM184B 0.35 5.8 0.3 1.56e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2486288 0.656 rs9920290 chr15:45548035 G/A cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.76 -0.51 2.15e-23 Glomerular filtration rate; LUSC cis rs7264396 0.790 rs761825 chr20:34194054 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -7.05 -0.36 1.03e-11 Total cholesterol levels; LUSC cis rs300703 0.719 rs446488 chr2:195365 T/C cg21211680 chr2:198530 NA 0.73 8.21 0.41 4.75e-15 Blood protein levels; LUSC cis rs11758351 1.000 rs76722536 chr6:26192946 C/G cg11342453 chr6:26196699 NA 0.56 5.92 0.31 8.04e-9 Gout;Renal underexcretion gout; LUSC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg11764359 chr7:65958608 NA -0.68 -11.03 -0.52 2.59e-24 Aortic root size; LUSC cis rs11122272 0.735 rs2486735 chr1:231521778 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg05802129 chr4:122689817 NA -0.36 -6.53 -0.34 2.41e-10 Type 2 diabetes; LUSC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg18252515 chr7:66147081 NA -1.23 -13.29 -0.59 1.17e-32 Diabetic kidney disease; LUSC cis rs62400317 0.762 rs529125 chr6:44797088 C/T cg20913747 chr6:44695427 NA 0.44 6.84 0.35 3.88e-11 Total body bone mineral density; LUSC cis rs1559088 0.947 rs12461297 chr19:33559245 A/G cg27124370 chr19:33622961 WDR88 0.53 6.69 0.34 9.21e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs61931739 0.517 rs1844525 chr12:34103183 T/A cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.39 0.46 9.85e-19 Prudent dietary pattern; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.17 0.61 5.11e-36 Platelet count; LUSC cis rs17270561 0.609 rs9366629 chr6:25741216 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs72781680 0.898 rs72796154 chr2:23933839 G/A cg08917208 chr2:24149416 ATAD2B 1.0 10.16 0.49 2.55e-21 Lymphocyte counts; LUSC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.47e-9 Electroencephalogram traits; LUSC cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg09469691 chr10:81107165 PPIF 0.7 10.86 0.51 1.01e-23 Height; LUSC cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.26 -0.32 1.15e-9 Bipolar disorder; LUSC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg12927641 chr6:109611667 NA 0.43 7.57 0.38 3.57e-13 Reticulocyte fraction of red cells; LUSC cis rs3806843 0.900 rs2563287 chr5:140124786 C/T cg03975922 chr5:140080575 ZMAT2 0.31 5.66 0.3 3.25e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg16325326 chr1:53192061 ZYG11B 0.82 14.18 0.61 4.69e-36 Monocyte count; LUSC cis rs4727027 0.704 rs7784122 chr7:148904624 A/G cg23583168 chr7:148888333 NA 0.9 17.9 0.7 9.82e-51 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs951366 0.576 rs11240559 chr1:205709621 T/G cg07167872 chr1:205819463 PM20D1 -0.44 -5.94 -0.31 7.02e-9 Menarche (age at onset); LUSC cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.17 0.32 2e-9 Schizophrenia; LUSC cis rs367943 0.966 rs455435 chr5:112799412 T/C cg12552261 chr5:112820674 MCC -0.44 -7.02 -0.36 1.25e-11 Type 2 diabetes; LUSC cis rs6918586 0.658 rs198854 chr6:26104057 T/C cg17691542 chr6:26056736 HIST1H1C 0.4 5.92 0.31 8.02e-9 Schizophrenia; LUSC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs10992471 0.756 rs2761681 chr9:95186937 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.47 -8.29 -0.41 2.86e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs7726839 0.561 rs72703046 chr5:580129 T/C cg11887960 chr12:57824829 NA 0.51 6.7 0.34 8.99e-11 Obesity-related traits; LUSC cis rs354225 0.544 rs10182538 chr2:54808251 T/A cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC trans rs6089829 0.926 rs1060491 chr20:61665817 C/A cg17470723 chr8:74884337 TCEB1 -0.5 -7.61 -0.38 2.88e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 0.507 rs6443274 chr3:9995288 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.6 8.64 0.43 2.39e-16 Alzheimer's disease; LUSC cis rs2414856 0.510 rs72758912 chr15:64641491 T/C cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg08807101 chr21:30365312 RNF160 0.78 14.39 0.62 7.48e-37 Dental caries; LUSC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12756686 chr19:29218302 NA 0.67 9.56 0.46 2.68e-19 Methadone dose in opioid dependence; LUSC trans rs1997103 1.000 rs10252413 chr7:55396740 C/G cg20935933 chr6:143382018 AIG1 0.5 7.24 0.37 3.1e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7216064 0.861 rs62084252 chr17:65879578 G/C cg12091567 chr17:66097778 LOC651250 -0.72 -9.46 -0.46 5.74e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs11048434 0.736 rs2377674 chr12:9112761 A/G cg13575925 chr12:9217583 LOC144571 0.35 6.66 0.34 1.12e-10 Sjögren's syndrome; LUSC cis rs713587 0.563 rs2033655 chr2:25101092 C/T cg04586622 chr2:25135609 ADCY3 0.39 8.1 0.41 1.03e-14 Body mass index in non-asthmatics; LUSC cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg18721089 chr20:30220636 NA -0.36 -6.19 -0.32 1.81e-9 Mean corpuscular hemoglobin; LUSC cis rs11690935 0.959 rs12692974 chr2:172663256 T/C cg13550731 chr2:172543902 DYNC1I2 -0.87 -14.43 -0.62 4.92e-37 Schizophrenia; LUSC cis rs9326248 0.520 rs1446105 chr11:116798544 C/T cg11861562 chr11:117069780 TAGLN 0.35 6.81 0.35 4.49e-11 Blood protein levels; LUSC cis rs6840360 0.571 rs7664663 chr4:152508014 G/C cg22705602 chr4:152727874 NA -0.32 -6.54 -0.34 2.28e-10 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.91 -0.44 3.32e-17 Autism spectrum disorder or schizophrenia; LUSC cis rs9916302 0.706 rs8067511 chr17:37611352 C/T cg07936489 chr17:37558343 FBXL20 -0.82 -10.02 -0.48 7.71e-21 Glomerular filtration rate (creatinine); LUSC cis rs9653442 0.564 rs7590378 chr2:100789877 A/G cg22139774 chr2:100720529 AFF3 -0.41 -7.04 -0.36 1.09e-11 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9039 1.000 rs9921107 chr16:9219845 G/T cg08831531 chr16:9218945 NA -0.66 -10.37 -0.49 4.91e-22 Menopause (age at onset); LUSC cis rs62400317 0.826 rs62400330 chr6:45321455 G/A cg18551225 chr6:44695536 NA -0.43 -7.25 -0.37 2.9e-12 Total body bone mineral density; LUSC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg25036284 chr2:26402008 FAM59B -0.71 -9.84 -0.47 3.15e-20 Gut microbiome composition (summer); LUSC trans rs57046232 0.552 rs932828 chr20:6340080 G/A cg17788362 chr6:86352627 SYNCRIP 0.42 6.03 0.31 4.36e-9 Colorectal cancer; LUSC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg00343986 chr7:65444356 GUSB -0.39 -5.87 -0.31 1.05e-8 Aortic root size; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg01879757 chr17:41196368 BRCA1 -0.39 -5.96 -0.31 6.57e-9 Menopause (age at onset); LUSC cis rs7100689 0.784 rs4258322 chr10:82184770 T/C cg00277334 chr10:82204260 NA -0.56 -7.53 -0.38 4.92e-13 Post bronchodilator FEV1; LUSC cis rs2290416 0.892 rs61652493 chr8:144669164 G/A cg26536354 chr8:144654954 C8orf73 0.67 7.3 0.37 2.18e-12 Attention deficit hyperactivity disorder; LUSC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg00334542 chr7:100209784 MOSPD3 -0.67 -7.82 -0.39 6.88e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC trans rs12210905 0.688 rs72843151 chr6:27359268 A/C cg11837749 chr1:55047332 ACOT11 0.68 6.07 0.32 3.38e-9 Hip circumference adjusted for BMI; LUSC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.64 0.57 3.49e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9875589 0.509 rs2129888 chr3:14013826 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 7.02 0.36 1.24e-11 Ovarian reserve; LUSC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg06850241 chr22:41845214 NA 0.32 5.83 0.3 1.28e-8 Vitiligo; LUSC cis rs9921222 0.521 rs62032884 chr16:363415 C/T cg00101154 chr16:420108 MRPL28 -0.44 -6.59 -0.34 1.74e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs11686934 0.780 rs6731423 chr2:70173327 A/C cg02498382 chr2:70120550 SNRNP27 -0.26 -6.58 -0.34 1.79e-10 High light scatter reticulocyte count; LUSC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.67 6.48 0.33 3.25e-10 Cerebrospinal P-tau181p levels; LUSC cis rs977987 0.806 rs6564258 chr16:75447363 G/A cg03315344 chr16:75512273 CHST6 0.48 8.92 0.44 3.16e-17 Dupuytren's disease; LUSC cis rs16910800 0.954 rs2449440 chr11:23200335 T/G cg20040320 chr11:23191996 NA 0.44 6.53 0.34 2.41e-10 Cancer; LUSC trans rs9944715 0.954 rs4453594 chr18:43788332 G/T cg01718231 chr17:29326311 RNF135 -0.54 -7.69 -0.39 1.65e-13 Red cell distribution width;Mean corpuscular volume; LUSC cis rs1461503 0.966 rs10790547 chr11:122842110 T/A cg27398637 chr11:122830231 C11orf63 -0.41 -6.54 -0.34 2.29e-10 Menarche (age at onset); LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg08219700 chr8:58056026 NA 0.64 8.18 0.41 6.2e-15 Developmental language disorder (linguistic errors); LUSC trans rs1005277 0.540 rs289638 chr10:37923731 G/A cg17830980 chr10:43048298 ZNF37B -0.4 -6.35 -0.33 7.16e-10 Extrinsic epigenetic age acceleration; LUSC cis rs13108904 0.557 rs1250097 chr4:1238338 C/T cg20887711 chr4:1340912 KIAA1530 -0.65 -9.97 -0.48 1.14e-20 Obesity-related traits; LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg14092988 chr3:52407081 DNAH1 0.32 6.21 0.32 1.59e-9 Bipolar disorder; LUSC cis rs2708377 0.932 rs2257110 chr12:11202522 G/C cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs11229555 0.874 rs12800710 chr11:58314540 C/T cg15696309 chr11:58395628 NA -0.69 -8.94 -0.44 2.61e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC trans rs61931739 0.649 rs815045 chr12:33722057 C/G cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg26727032 chr16:67993705 SLC12A4 -0.45 -5.81 -0.3 1.43e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs12541635 0.677 rs7003520 chr8:107061724 G/A cg10147462 chr8:107024639 NA 0.66 13.87 0.6 7.11e-35 Age of smoking initiation; LUSC cis rs9309473 0.528 rs10191517 chr2:73558403 G/A cg20560298 chr2:73613845 ALMS1 -0.53 -7.79 -0.39 8.68e-14 Metabolite levels; LUSC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg17143192 chr8:8559678 CLDN23 -0.68 -9.68 -0.47 1.1e-19 Obesity-related traits; LUSC cis rs1153858 1.000 rs2467858 chr15:45711492 A/G cg21132104 chr15:45694354 SPATA5L1 0.56 7.77 0.39 1.01e-13 Homoarginine levels; LUSC cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg08999081 chr20:33150536 PIGU 0.38 6.89 0.35 2.76e-11 Height; LUSC cis rs6964587 0.626 rs12704631 chr7:91523525 T/C cg17063962 chr7:91808500 NA -0.56 -9.25 -0.45 2.75e-18 Breast cancer; LUSC cis rs7759001 0.817 rs10080571 chr6:27363150 G/C cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.27e-8 Glomerular filtration rate (creatinine); LUSC cis rs12421382 0.659 rs1866530 chr11:109380899 T/A cg27471124 chr11:109292789 C11orf87 0.41 7.09 0.36 8.05e-12 Schizophrenia; LUSC trans rs6952808 0.723 rs4721264 chr7:2012997 G/A cg04565464 chr8:145669602 NFKBIL2 0.36 6.02 0.31 4.47e-9 Bipolar disorder and schizophrenia; LUSC cis rs6690583 0.623 rs898036 chr1:85521904 A/T cg11262906 chr1:85462892 MCOLN2 0.68 6.32 0.33 8.43e-10 Serum sulfate level; LUSC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg26597838 chr10:835615 NA 1.23 16.23 0.66 4.34e-44 Eosinophil percentage of granulocytes; LUSC cis rs1348850 0.632 rs12616288 chr2:178503813 G/T cg22681709 chr2:178499509 PDE11A -0.59 -11.83 -0.54 3.26e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7215564 0.818 rs35459747 chr17:78661475 T/C cg09596252 chr17:78655493 RPTOR 0.55 6.05 0.31 3.97e-9 Myopia (pathological); LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 16.51 0.67 3.47e-45 Gut microbiome composition (summer); LUSC cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -6.61 -0.34 1.51e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs7772486 0.875 rs9403765 chr6:146368041 C/T cg23711669 chr6:146136114 FBXO30 -0.84 -14.75 -0.63 2.85e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg02034447 chr16:89574710 SPG7 0.41 6.34 0.33 7.62e-10 Multiple myeloma (IgH translocation); LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -8.69 -0.43 1.7e-16 Lymphocyte counts; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03315476 chr1:40915606 ZNF643 -0.43 -5.97 -0.31 6.01e-9 Hepatitis; LUSC cis rs72777070 0.652 rs7608996 chr2:9795757 C/T cg14973360 chr2:9800511 NA 0.38 5.73 0.3 2.2e-8 Platelet-derived growth factor BB levels; LUSC cis rs7819412 0.505 rs17782536 chr8:11021682 A/G cg21775007 chr8:11205619 TDH -0.52 -7.15 -0.36 5.38e-12 Triglycerides; LUSC cis rs7584330 0.554 rs76980036 chr2:238426750 G/A cg16989719 chr2:238392110 NA -0.43 -6.2 -0.32 1.65e-9 Prostate cancer; LUSC trans rs7647973 0.626 rs11130217 chr3:49737323 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -6.87 -0.35 3.06e-11 Menarche (age at onset); LUSC cis rs7520050 0.898 rs34175029 chr1:46483871 C/T cg06784218 chr1:46089804 CCDC17 -0.29 -5.69 -0.3 2.83e-8 Red blood cell count;Reticulocyte count; LUSC cis rs1113500 0.933 rs11185256 chr1:108633957 C/T cg06207961 chr1:108661230 NA 0.41 7.61 0.38 2.89e-13 Growth-regulated protein alpha levels; LUSC cis rs9549367 0.756 rs9549702 chr13:113881944 T/G cg00898013 chr13:113819073 PROZ -0.56 -8.49 -0.42 6.86e-16 Platelet distribution width; LUSC cis rs7089973 0.604 rs11196929 chr10:116582080 G/C cg23260525 chr10:116636907 FAM160B1 0.43 9.16 0.45 5.47e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4343996 0.754 rs2340848 chr7:3492446 G/A cg21248987 chr7:3385318 SDK1 0.35 5.69 0.3 2.81e-8 Motion sickness; LUSC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg05623727 chr3:50126028 RBM5 0.31 5.81 0.3 1.43e-8 Intelligence (multi-trait analysis); LUSC trans rs2262909 0.889 rs61268244 chr19:22310130 C/T cg17074339 chr11:11642133 GALNTL4 0.44 6.69 0.34 9.25e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg22907277 chr7:1156413 C7orf50 0.73 10.41 0.5 3.58e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs62458065 0.713 rs1597560 chr7:32493886 C/G cg00845942 chr12:64062724 DPY19L2 -0.54 -6.45 -0.33 3.83e-10 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg23711669 chr6:146136114 FBXO30 0.86 15.72 0.65 4.59e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC trans rs9951602 0.512 rs77157626 chr18:76644771 C/T cg02800362 chr5:177631904 HNRNPAB 0.84 12.56 0.57 6.68e-30 Obesity-related traits; LUSC cis rs6736093 1.000 rs4848861 chr2:112668835 A/G cg12686935 chr2:112915763 FBLN7 0.38 5.76 0.3 1.89e-8 Coronary artery disease; LUSC cis rs7917772 0.582 rs7087984 chr10:104380686 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.69 11.13 0.52 1.07e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9914988 1.000 rs9916866 chr17:27183155 C/G cg19789473 chr17:27170043 C17orf63 0.31 6.19 0.32 1.79e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC trans rs9650657 0.585 rs4841401 chr8:10489592 C/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.28 -0.32 1.06e-9 Neuroticism; LUSC cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg23262351 chr6:79576851 IRAK1BP1 -0.4 -6.14 -0.32 2.3e-9 Intelligence (multi-trait analysis); LUSC cis rs9296092 0.560 rs9469500 chr6:33526196 C/T cg13560919 chr6:33536144 NA -0.84 -16.17 -0.66 7.8e-44 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18404041 chr3:52824283 ITIH1 0.56 10.81 0.51 1.46e-23 Bipolar disorder; LUSC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg06636001 chr8:8085503 FLJ10661 0.59 8.89 0.44 3.97e-17 Mood instability; LUSC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -6.36 -0.33 6.82e-10 Joint mobility (Beighton score); LUSC cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.35 2.1e-11 Monocyte percentage of white cells; LUSC cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg06784218 chr1:46089804 CCDC17 0.51 9.89 0.48 2.11e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23712970 chr14:23540735 ACIN1 0.55 7.54 0.38 4.41e-13 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC trans rs2567519 0.710 rs2714012 chr17:70783757 C/T cg06482044 chr16:31191169 FUS -0.39 -6.05 -0.31 3.95e-9 Smoking initiation; LUSC trans rs2243480 1.000 rs60683927 chr7:65394768 T/C cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.75 -0.35 6.52e-11 Lung cancer; LUSC trans rs12579753 0.879 rs11115002 chr12:82153090 C/T cg07923666 chr12:49932857 KCNH3 -0.53 -6.59 -0.34 1.74e-10 Resting heart rate; LUSC cis rs35146811 0.735 rs858505 chr7:99819577 G/A cg22906224 chr7:99728672 NA -0.5 -6.99 -0.36 1.49e-11 Coronary artery disease; LUSC cis rs936229 1.000 rs4886615 chr15:75131661 A/G cg10253484 chr15:75165896 SCAMP2 -0.52 -6.84 -0.35 3.9e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg25637963 chr5:138629068 MATR3 0.37 6.21 0.32 1.53e-9 Schizophrenia; LUSC cis rs45535039 0.506 rs4936467 chr11:119086629 A/T cg16724696 chr11:118992527 HINFP -0.53 -7.62 -0.38 2.66e-13 Plateletcrit; LUSC cis rs17270561 0.609 rs7746502 chr6:25718762 T/A cg16482183 chr6:26056742 HIST1H1C -0.56 -8.03 -0.4 1.73e-14 Iron status biomarkers; LUSC cis rs3087591 0.887 rs1013946 chr17:29530350 A/C cg24425628 chr17:29625626 OMG;NF1 0.58 8.72 0.43 1.34e-16 Hip circumference; LUSC cis rs3862030 0.839 rs12570859 chr10:104257226 C/T cg05855489 chr10:104503620 C10orf26 0.5 7.48 0.38 6.64e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs6547741 0.717 rs2178197 chr2:27860551 C/T cg27432699 chr2:27873401 GPN1 0.88 17.32 0.69 2.17e-48 Oral cavity cancer; LUSC cis rs11031096 0.536 rs894459 chr11:4213590 A/G cg18678763 chr11:4115507 RRM1 -0.42 -5.82 -0.3 1.38e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7107174 0.581 rs11237485 chr11:78126011 G/A cg27205649 chr11:78285834 NARS2 -0.52 -5.69 -0.3 2.85e-8 Testicular germ cell tumor; LUSC cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg13256891 chr4:100009986 ADH5 -0.42 -5.69 -0.3 2.74e-8 Alcohol dependence; LUSC cis rs3126085 0.778 rs9887901 chr1:152248552 A/C cg26876637 chr1:152193138 HRNR 0.45 6.03 0.31 4.34e-9 Atopic dermatitis; LUSC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg20891283 chr12:69753455 YEATS4 0.8 14.43 0.62 4.94e-37 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13824859 chr6:109804376 ZBTB24 -0.4 -6.1 -0.32 3e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg15691649 chr6:25882328 NA -0.51 -7.11 -0.36 6.97e-12 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg26384229 chr12:38710491 ALG10B 0.91 15.54 0.65 2.38e-41 Bladder cancer; LUSC trans rs877282 1.000 rs71491304 chr10:772982 C/T cg13042288 chr15:90349979 ANPEP -0.48 -6.91 -0.35 2.46e-11 Uric acid levels; LUSC cis rs11098499 0.754 rs4107728 chr4:120253910 G/A cg09307838 chr4:120376055 NA 0.7 10.69 0.5 3.89e-23 Corneal astigmatism; LUSC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg12463550 chr7:65579703 CRCP 0.41 5.89 0.31 9.19e-9 Aortic root size; LUSC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg12639453 chr1:2035780 PRKCZ -0.33 -7.17 -0.37 4.76e-12 Height; LUSC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg09034736 chr1:150693464 HORMAD1 -0.5 -7.32 -0.37 1.87e-12 Tonsillectomy; LUSC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg19901468 chr14:105411992 AHNAK2 -0.71 -12.47 -0.56 1.43e-29 Rheumatoid arthritis; LUSC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg19748678 chr4:122722346 EXOSC9 0.74 11.17 0.52 7.89e-25 Type 2 diabetes; LUSC cis rs710216 0.797 rs1770811 chr1:43400547 A/T cg03128534 chr1:43423976 SLC2A1 0.45 5.73 0.3 2.2e-8 Red cell distribution width; LUSC cis rs9341808 0.655 rs9350846 chr6:80865481 T/A cg08355045 chr6:80787529 NA 0.56 9.59 0.46 2.07e-19 Sitting height ratio; LUSC cis rs3106136 0.967 rs13132963 chr4:95219780 A/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.25 -0.32 1.29e-9 Capecitabine sensitivity; LUSC cis rs2739330 0.828 rs5760099 chr22:24248414 G/A cg25703541 chr22:24373054 LOC391322 -0.89 -14.5 -0.62 2.8e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 6.97 0.36 1.7e-11 Bipolar disorder; LUSC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.24e-10 Height; LUSC cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.03 0.85 2.44e-93 Chronic sinus infection; LUSC trans rs11123259 0.761 rs6723421 chr2:115699213 C/T cg00844339 chr9:138873417 NA 0.3 5.99 0.31 5.35e-9 Gut microbiome composition (winter); LUSC cis rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05901451 chr6:126070800 HEY2 -0.79 -14.19 -0.61 4.31e-36 Brugada syndrome; LUSC trans rs1814175 0.817 rs7483795 chr11:49704930 G/A cg15704280 chr7:45808275 SEPT13 -1.12 -24.19 -0.8 2.08e-75 Height; LUSC cis rs3740540 0.530 rs2362505 chr10:126290739 T/G cg04949429 chr10:126290192 LHPP 0.36 7.64 0.39 2.29e-13 Obesity-related traits;Acute lymphoblastic leukemia (childhood); LUSC trans rs3942852 0.712 rs10742828 chr11:48104555 A/G cg03929089 chr4:120376271 NA -0.53 -6.5 -0.34 3.01e-10 Acute lymphoblastic leukemia (childhood); LUSC cis rs7267979 1.000 rs2500405 chr20:25360826 A/G cg03522245 chr20:25566470 NINL -0.35 -5.78 -0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg01802117 chr1:53393560 SCP2 0.38 6.2 0.32 1.67e-9 Monocyte count; LUSC cis rs1358748 0.520 rs2815342 chr1:67532313 G/A cg02640540 chr1:67518911 SLC35D1 0.62 6.52 0.34 2.6e-10 Tuberculosis; LUSC cis rs793571 0.590 rs17190727 chr15:59073790 C/A cg05156742 chr15:59063176 FAM63B 0.55 8.44 0.42 9.9e-16 Schizophrenia; LUSC cis rs1808579 0.904 rs1788783 chr18:21161134 C/T cg14672496 chr18:21087552 C18orf8 0.35 6.16 0.32 2.08e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg12379764 chr21:47803548 PCNT -0.42 -5.95 -0.31 6.93e-9 Testicular germ cell tumor; LUSC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg02574844 chr11:5959923 NA -0.45 -6.21 -0.32 1.56e-9 DNA methylation (variation); LUSC trans rs2727020 0.637 rs1164673 chr11:49328356 C/G cg03929089 chr4:120376271 NA 0.5 7.14 0.36 5.78e-12 Coronary artery disease; LUSC cis rs6754311 0.517 rs1865452 chr2:136539330 C/T cg07169764 chr2:136633963 MCM6 0.87 12.0 0.55 7.99e-28 Mosquito bite size; LUSC cis rs3820928 0.874 rs7582251 chr2:227791703 G/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.72 -0.39 1.38e-13 Pulmonary function; LUSC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.93 0.48 1.57e-20 Hip circumference adjusted for BMI; LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg24060327 chr5:131705240 SLC22A5 -0.5 -7.93 -0.4 3.33e-14 Acylcarnitine levels; LUSC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg24675658 chr1:53192096 ZYG11B -0.64 -10.67 -0.5 4.56e-23 Monocyte count; LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg09033563 chr22:24373618 LOC391322 -0.59 -9.05 -0.44 1.16e-17 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2742417 0.603 rs2742374 chr3:45784082 T/C cg10512202 chr3:45649293 LIMD1 0.36 6.09 0.32 3.17e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg09365446 chr1:150670422 GOLPH3L 0.52 7.9 0.4 4.17e-14 Melanoma; LUSC cis rs73198271 0.700 rs10090152 chr8:8652104 C/A cg01851573 chr8:8652454 MFHAS1 0.51 8.18 0.41 5.98e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7575217 0.767 rs4851407 chr2:101759182 G/A cg23907051 chr2:101730305 TBC1D8 -0.28 -7.33 -0.37 1.77e-12 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg15112475 chr7:1198522 ZFAND2A -0.38 -8.49 -0.42 6.67e-16 Longevity;Endometriosis; LUSC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg01017244 chr2:74357527 NA 0.67 13.0 0.58 1.45e-31 Gestational age at birth (maternal effect); LUSC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs11583043 1.000 rs17123612 chr1:101476814 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 6.01 0.31 4.96e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4588572 0.643 rs1529499 chr5:77721431 T/C cg11547950 chr5:77652471 NA -0.55 -7.91 -0.4 3.82e-14 Triglycerides; LUSC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg04673462 chr1:38461896 NA -0.54 -8.61 -0.43 2.88e-16 Coronary artery disease; LUSC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg23711669 chr6:146136114 FBXO30 0.85 15.91 0.66 8.01e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg05623727 chr3:50126028 RBM5 -0.34 -6.37 -0.33 6.27e-10 Intelligence (multi-trait analysis); LUSC cis rs10089 0.953 rs1985268 chr5:127375931 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.84 12.09 0.55 3.72e-28 Ileal carcinoids; LUSC cis rs1355223 0.583 rs2941044 chr11:34867444 A/C cg11058730 chr11:34937778 PDHX;APIP 0.7 11.31 0.53 2.55e-25 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs7169223 0.653 rs2904228 chr15:79086099 G/A cg21242079 chr15:79101063 ADAMTS7 -0.4 -5.74 -0.3 2.07e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9420 0.961 rs17455520 chr11:57540458 C/A cg23127183 chr11:57508653 C11orf31 -0.57 -8.81 -0.43 6.86e-17 Schizophrenia; LUSC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg12463550 chr7:65579703 CRCP -0.57 -8.62 -0.43 2.65e-16 Aortic root size; LUSC cis rs868036 0.672 rs7175517 chr15:68077630 A/G cg05925327 chr15:68127851 NA -0.43 -6.95 -0.36 1.91e-11 Restless legs syndrome; LUSC cis rs1185460 0.967 rs1784461 chr11:118937985 G/A cg01677386 chr11:118938358 VPS11 -0.48 -6.82 -0.35 4.41e-11 Coronary artery disease; LUSC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg03188948 chr7:1209495 NA 0.46 6.16 0.32 2.11e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11122272 0.735 rs910822 chr1:231498721 G/A cg06096015 chr1:231504339 EGLN1 0.56 9.99 0.48 9.69e-21 Hemoglobin concentration; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg02475777 chr4:1388615 CRIPAK 0.45 6.76 0.35 6.33e-11 Obesity-related traits; LUSC cis rs1371867 0.846 rs1613453 chr8:101244215 G/T cg00191853 chr8:101177733 SPAG1 0.36 5.93 0.31 7.41e-9 Atrioventricular conduction; LUSC cis rs17401966 0.540 rs1467653 chr1:10413123 A/G cg17425144 chr1:10567563 PEX14 0.34 6.1 0.32 2.99e-9 Hepatocellular carcinoma; LUSC cis rs9815354 0.638 rs75687617 chr3:42044664 C/T cg03022575 chr3:42003672 ULK4 0.78 7.87 0.4 5.1e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg12311346 chr5:56204834 C5orf35 0.84 13.98 0.61 2.88e-35 Initial pursuit acceleration; LUSC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg08847533 chr14:75593920 NEK9 -0.85 -15.31 -0.64 1.84e-40 Height; LUSC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg06634786 chr22:41940651 POLR3H -0.55 -6.46 -0.33 3.75e-10 Vitiligo; LUSC cis rs7605378 0.752 rs769960 chr2:200710706 G/T cg17644776 chr2:200775616 C2orf69 -0.46 -7.33 -0.37 1.75e-12 Osteoporosis; LUSC cis rs11645898 0.687 rs1424241 chr16:72078907 G/A cg14768367 chr16:72042858 DHODH -0.56 -6.62 -0.34 1.47e-10 Blood protein levels; LUSC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg15704280 chr7:45808275 SEPT13 -1.13 -24.93 -0.81 3.04e-78 Height; LUSC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg19592336 chr6:28129416 ZNF389 0.48 6.29 0.33 1.02e-9 Depression; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg19187486 chr15:74833838 ARID3B 0.39 6.14 0.32 2.3e-9 Schizophrenia; LUSC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg23283495 chr1:209979779 IRF6 0.51 8.28 0.41 3.04e-15 Monobrow; LUSC cis rs7119 0.717 rs35284122 chr15:77804568 G/T cg27398640 chr15:77910606 LINGO1 -0.29 -6.18 -0.32 1.89e-9 Type 2 diabetes; LUSC cis rs7538876 0.935 rs4920607 chr1:17760098 A/G cg07965774 chr1:17746286 RCC2 0.35 6.54 0.34 2.29e-10 Basal cell carcinoma; LUSC cis rs7107174 1.000 rs2512549 chr11:77940163 A/G cg02023728 chr11:77925099 USP35 -0.56 -8.03 -0.4 1.67e-14 Testicular germ cell tumor; LUSC cis rs250677 0.522 rs2217638 chr5:148364355 A/G cg18129178 chr5:148520854 ABLIM3 0.54 7.89 0.4 4.28e-14 Breast cancer; LUSC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg05738196 chr6:26577821 NA -0.59 -6.93 -0.35 2.12e-11 Intelligence (multi-trait analysis); LUSC cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg15103426 chr22:29168792 CCDC117 0.46 5.93 0.31 7.38e-9 Lymphocyte counts; LUSC cis rs12760731 0.565 rs2095133 chr1:178198612 C/G cg00404053 chr1:178313656 RASAL2 0.66 6.86 0.35 3.32e-11 Obesity-related traits; LUSC cis rs9378688 1.000 rs56196406 chr6:2219565 T/C cg12303981 chr6:2244766 GMDS -0.5 -5.98 -0.31 5.89e-9 Caudate nucleus volume; LUSC cis rs6541297 0.702 rs4846904 chr1:230279410 G/A cg20703242 chr1:230279135 GALNT2 0.52 8.2 0.41 5.22e-15 Coronary artery disease; LUSC cis rs7267979 1.000 rs11087520 chr20:25436827 C/T cg08601574 chr20:25228251 PYGB 0.43 6.51 0.34 2.77e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Vitiligo; LUSC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg03453431 chr7:157225567 NA -0.69 -13.33 -0.59 8.46e-33 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg24110177 chr3:50126178 RBM5 -0.55 -8.96 -0.44 2.33e-17 Intelligence (multi-trait analysis); LUSC cis rs3540 0.553 rs4031431 chr15:90990782 G/T cg22089800 chr15:90895588 ZNF774 0.63 9.4 0.46 9.03e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs12474201 0.832 rs4952843 chr2:46957845 A/G cg06386533 chr2:46925753 SOCS5 0.68 9.96 0.48 1.2e-20 Height; LUSC cis rs2281845 1.000 rs2281845 chr1:201081943 C/T cg17810781 chr1:201082982 CACNA1S 0.33 6.33 0.33 7.95e-10 Permanent tooth development; LUSC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg02487422 chr3:49467188 NICN1 0.47 7.38 0.37 1.27e-12 Resting heart rate; LUSC cis rs71636778 0.543 rs17162333 chr1:27236757 C/G cg12203394 chr1:27248618 NUDC 0.54 5.71 0.3 2.52e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; LUSC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg18876405 chr7:65276391 NA -0.57 -9.23 -0.45 3.22e-18 Aortic root size; LUSC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg05025164 chr4:1340916 KIAA1530 0.63 10.06 0.48 5.51e-21 Longevity; LUSC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg12350822 chr6:88032061 C6orf162;GJB7 0.65 13.93 0.61 4.22e-35 Monocyte percentage of white cells; LUSC cis rs7666738 0.515 rs13131874 chr4:98779183 A/G cg03676636 chr4:99064102 C4orf37 0.3 5.97 0.31 6.04e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs611744 0.517 rs62537573 chr8:109269281 C/T cg18478394 chr8:109455254 TTC35 0.47 7.28 0.37 2.38e-12 Dupuytren's disease; LUSC cis rs11105298 0.891 rs6538189 chr12:89885923 C/A cg00757033 chr12:89920650 WDR51B 0.6 10.35 0.49 5.9e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs453301 0.686 rs6601280 chr8:8909236 A/T cg06636001 chr8:8085503 FLJ10661 0.53 7.47 0.38 6.85e-13 Joint mobility (Beighton score); LUSC cis rs6977660 0.714 rs6945297 chr7:19814029 A/C cg07541023 chr7:19748670 TWISTNB 0.66 7.24 0.37 3.12e-12 Thyroid stimulating hormone; LUSC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg04450456 chr4:17643702 FAM184B 0.4 6.75 0.35 6.6e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs2055729 0.528 rs11987861 chr8:9742206 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -6.07 -0.32 3.48e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs372883 0.967 rs2832290 chr21:30728863 C/T cg08807101 chr21:30365312 RNF160 -0.45 -6.54 -0.34 2.29e-10 Pancreatic cancer; LUSC cis rs7560272 0.538 rs12053242 chr2:73937168 G/A cg20560298 chr2:73613845 ALMS1 0.4 6.11 0.32 2.8e-9 Schizophrenia; LUSC cis rs56161922 0.908 rs78159416 chr1:207820375 C/A cg11752769 chr1:207818423 CR1L -0.7 -6.1 -0.32 2.87e-9 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); LUSC cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg24692254 chr21:30365293 RNF160 0.76 11.63 0.54 1.78e-26 Selective IgA deficiency; LUSC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.84 12.01 0.55 7.01e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg08683831 chr4:1404607 NA 0.35 5.7 0.3 2.62e-8 Obesity-related traits; LUSC cis rs9398803 0.865 rs2184968 chr6:126760994 A/G cg19875578 chr6:126661172 C6orf173 0.39 5.73 0.3 2.18e-8 Male-pattern baldness; LUSC trans rs61931739 0.534 rs11053000 chr12:34079022 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.47 0.42 7.79e-16 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs11053248 chr12:34518011 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.57 0.65 1.71e-41 Morning vs. evening chronotype; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.72e-10 Bipolar disorder; LUSC cis rs4704187 0.687 rs6885887 chr5:74497842 A/C cg03227963 chr5:74354835 NA 0.31 6.76 0.35 6.17e-11 Response to amphetamines; LUSC cis rs12681287 0.640 rs4961193 chr8:87486168 C/T cg27223183 chr8:87520930 FAM82B 0.53 7.29 0.37 2.33e-12 Caudate activity during reward; LUSC cis rs2901656 0.652 rs3213563 chr1:172412995 T/C cg03748243 chr1:172413542 C1orf105;PIGC 0.39 8.13 0.41 8.32e-15 Red cell distribution width;Platelet distribution width; LUSC cis rs7258465 1.000 rs271621 chr19:18631332 C/A cg11102782 chr19:18549136 ISYNA1 -0.32 -6.05 -0.31 3.93e-9 Breast cancer; LUSC cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg13010199 chr12:38710504 ALG10B 0.66 10.19 0.49 2.02e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs16910800 0.953 rs7110229 chr11:23200546 C/T cg20040320 chr11:23191996 NA -0.45 -6.63 -0.34 1.37e-10 Cancer; LUSC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.54 0.38 4.59e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg03146154 chr1:46216737 IPP 0.54 8.22 0.41 4.47e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08393024 chr5:115177154 ATG12;AP3S1 0.39 6.05 0.31 3.96e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs372883 0.564 rs766928 chr21:30753606 A/G cg08807101 chr21:30365312 RNF160 0.66 10.28 0.49 1.01e-21 Pancreatic cancer; LUSC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg03732007 chr1:2071316 PRKCZ -0.5 -8.63 -0.43 2.49e-16 Height; LUSC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.63 0.39 2.55e-13 Crohn's disease; LUSC cis rs2625529 0.730 rs7177242 chr15:72184114 A/G cg16672083 chr15:72433130 SENP8 0.52 8.13 0.41 8.41e-15 Red blood cell count; LUSC cis rs2439831 0.850 rs16963953 chr15:44081719 A/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.93 0.35 2.12e-11 Lung cancer in ever smokers; LUSC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg08677398 chr8:58056175 NA 0.54 6.29 0.33 9.81e-10 Developmental language disorder (linguistic errors); LUSC cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs9303280 0.836 rs12453507 chr17:38053207 C/G cg26162295 chr17:38119207 GSDMA 0.24 5.68 0.3 3.01e-8 Self-reported allergy; LUSC trans rs2386661 0.547 rs57893347 chr10:5646191 G/A cg11398623 chr21:37499189 NA 0.27 6.19 0.32 1.77e-9 Breast cancer; LUSC cis rs1858037 0.867 rs72621551 chr2:65615221 C/T cg08085232 chr2:65598271 SPRED2 -0.42 -6.29 -0.33 9.78e-10 Rheumatoid arthritis; LUSC cis rs6681460 1.000 rs6696927 chr1:67070381 A/G cg02459107 chr1:67143332 SGIP1 0.49 9.23 0.45 3.18e-18 Presence of antiphospholipid antibodies; LUSC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg04518342 chr5:131593106 PDLIM4 -0.45 -7.65 -0.39 2.15e-13 Breast cancer; LUSC cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg24642439 chr20:33292090 TP53INP2 0.5 7.43 0.38 8.94e-13 Height; LUSC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg18230493 chr5:56204884 C5orf35 0.77 12.46 0.56 1.63e-29 Initial pursuit acceleration; LUSC cis rs4595586 0.545 rs7967295 chr12:39376866 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg06873352 chr17:61820015 STRADA 0.57 8.78 0.43 8.9e-17 Height; LUSC cis rs9467711 0.606 rs66827971 chr6:26365766 T/C cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs965513 1.000 rs10983701 chr9:100537577 G/A cg13688889 chr9:100608707 NA -0.57 -8.61 -0.43 2.87e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs2235642 0.685 rs2667681 chr16:1653206 C/T cg09025071 chr16:1593152 IFT140;TMEM204 0.3 6.68 0.34 9.74e-11 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25462384 chr19:7985170 SNAPC2 -0.39 -6.06 -0.31 3.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg19622623 chr12:86230825 RASSF9 -0.44 -6.34 -0.33 7.26e-10 Major depressive disorder; LUSC cis rs926938 0.527 rs7526844 chr1:115543759 T/C cg12756093 chr1:115239321 AMPD1 0.48 7.19 0.37 4.23e-12 Autism; LUSC cis rs1775715 0.870 rs3847414 chr10:32219176 A/G cg04359828 chr10:32216031 ARHGAP12 0.38 6.55 0.34 2.23e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs41271473 0.948 rs17437060 chr1:228822374 C/T cg10167378 chr1:228756711 NA 0.6 7.15 0.36 5.44e-12 Chronic lymphocytic leukemia; LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg08472276 chr7:1133186 C7orf50;GPER -0.38 -6.21 -0.32 1.57e-9 Longevity;Endometriosis; LUSC cis rs36093844 0.660 rs12274717 chr11:85577714 A/C cg25872744 chr11:85566296 CCDC83 -0.45 -5.98 -0.31 5.7e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg03526776 chr6:41159608 TREML2 0.33 6.12 0.32 2.67e-9 Alzheimer's disease (late onset); LUSC cis rs1728785 1.000 rs1749791 chr16:68572347 C/T cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg21435336 chr19:17392852 ANKLE1 -0.42 -5.77 -0.3 1.82e-8 Systemic lupus erythematosus; LUSC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg27494647 chr7:150038898 RARRES2 0.47 7.29 0.37 2.19e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg12463550 chr7:65579703 CRCP 0.42 6.01 0.31 4.74e-9 Aortic root size; LUSC cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg06784218 chr1:46089804 CCDC17 0.48 9.63 0.47 1.62e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg06637938 chr14:75390232 RPS6KL1 0.54 8.65 0.43 2.16e-16 Height; LUSC cis rs10905065 0.931 rs11255228 chr10:5837671 T/C cg11519256 chr10:5708881 ASB13 0.4 5.78 0.3 1.68e-8 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03609454 chr4:36245858 ARAP2 -0.44 -6.63 -0.34 1.34e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4148883 0.645 rs2851287 chr4:100014548 G/A cg12011299 chr4:100065546 ADH4 0.49 8.08 0.4 1.21e-14 Alcohol dependence; LUSC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg05425664 chr17:57184151 TRIM37 -0.52 -7.73 -0.39 1.31e-13 Intelligence (multi-trait analysis); LUSC cis rs2204008 0.702 rs3849999 chr12:38483498 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.28 -0.41 2.99e-15 Bladder cancer; LUSC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg25204440 chr1:209979598 IRF6 0.53 6.98 0.36 1.59e-11 Cleft lip with or without cleft palate; LUSC trans rs3808502 0.503 rs2061830 chr8:11397457 C/G cg11608241 chr8:8085544 FLJ10661 0.42 6.04 0.31 4.1e-9 Neuroticism; LUSC cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 29.03 0.85 2.35e-93 Chronic sinus infection; LUSC cis rs8044995 0.563 rs2279540 chr16:68395061 T/C cg09835421 chr16:68378352 PRMT7 -0.76 -8.47 -0.42 7.75e-16 Schizophrenia; LUSC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg18252515 chr7:66147081 NA 1.24 14.21 0.61 3.56e-36 Diabetic kidney disease; LUSC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg03433033 chr1:76189801 ACADM 0.75 10.28 0.49 1.02e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg23758822 chr17:41437982 NA 1.04 19.86 0.74 1.7e-58 Menopause (age at onset); LUSC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6464929 0.955 rs7793916 chr7:148724043 G/A cg23583168 chr7:148888333 NA 0.46 5.87 0.31 1.07e-8 Pediatric bone mineral content (hip); LUSC cis rs2078087 0.522 rs4652787 chr1:183225089 G/A cg13843938 chr1:183241246 NMNAT2 0.4 6.52 0.34 2.65e-10 Obesity-related traits; LUSC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Melanoma; LUSC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs782590 0.807 rs782572 chr2:55912120 T/C cg18811423 chr2:55921094 PNPT1 0.9 16.03 0.66 2.76e-43 Metabolic syndrome; LUSC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg07701084 chr6:150067640 NUP43 0.58 9.17 0.45 5.08e-18 Lung cancer; LUSC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg07211511 chr3:129823064 LOC729375 -1.23 -20.54 -0.75 3.35e-61 Blood pressure (smoking interaction); LUSC trans rs34421088 0.576 rs2572432 chr8:11101723 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.74 -0.35 7.16e-11 Neuroticism; LUSC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg10792982 chr14:105748885 BRF1 0.47 8.55 0.42 4.54e-16 Mean platelet volume;Platelet distribution width; LUSC cis rs11098499 0.865 rs9994730 chr4:120381564 A/C cg24375607 chr4:120327624 NA 0.78 11.63 0.54 1.74e-26 Corneal astigmatism; LUSC cis rs425277 0.583 rs925905 chr1:2044037 T/C cg04315214 chr1:2043799 PRKCZ 0.48 10.08 0.48 4.71e-21 Height; LUSC cis rs1506636 0.525 rs7812023 chr7:123260228 C/T cg03229431 chr7:123269106 ASB15 -0.61 -9.21 -0.45 3.77e-18 Plateletcrit;Platelet count; LUSC cis rs929354 1.000 rs1182391 chr7:157038368 T/C cg17757837 chr7:157058334 UBE3C -0.92 -15.79 -0.65 2.34e-42 Body mass index; LUSC trans rs61931739 0.613 rs1525898 chr12:33904445 G/T cg13010199 chr12:38710504 ALG10B 0.4 5.99 0.31 5.56e-9 Morning vs. evening chronotype; LUSC cis rs4888262 0.526 rs4887772 chr16:74537591 C/T cg01733217 chr16:74700730 RFWD3 0.74 12.32 0.56 5.29e-29 Testicular germ cell tumor; LUSC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg03188948 chr7:1209495 NA 0.46 6.14 0.32 2.34e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg17366294 chr4:99064904 C4orf37 -0.59 -10.49 -0.5 1.94e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs7202877 0.706 rs247438 chr16:75432649 C/G cg03315344 chr16:75512273 CHST6 -0.41 -6.18 -0.32 1.84e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Vitiligo; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg09368129 chr5:140071347 HARS2;HARS 0.47 6.13 0.32 2.48e-9 Cognitive function;Information processing speed; LUSC cis rs2361718 0.500 rs4889818 chr17:78085228 A/G cg20811857 chr17:78079795 GAA -0.46 -7.64 -0.39 2.39e-13 Yeast infection; LUSC cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg24112000 chr20:60950667 NA 0.35 6.56 0.34 2.08e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs10463316 0.862 rs11740475 chr5:150777997 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.69 -0.39 1.67e-13 Metabolite levels (Pyroglutamine); LUSC cis rs7707921 0.881 rs7733122 chr5:81351443 C/T cg15871215 chr5:81402204 ATG10 -0.45 -6.48 -0.33 3.3e-10 Breast cancer; LUSC trans rs61931739 0.534 rs1586410 chr12:33999142 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.27 0.41 3.18e-15 Morning vs. evening chronotype; LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg08470875 chr2:26401718 FAM59B 0.74 9.89 0.48 2.15e-20 Gut microbiome composition (summer); LUSC cis rs735396 0.770 rs2464196 chr12:121435427 G/A cg02403541 chr12:121454288 C12orf43 0.72 10.41 0.5 3.5e-22 N-glycan levels; LUSC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg27094323 chr7:1216898 NA -0.37 -6.74 -0.35 7.05e-11 Longevity;Endometriosis; LUSC cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg10523679 chr1:76189770 ACADM -0.48 -7.06 -0.36 9.79e-12 Daytime sleep phenotypes; LUSC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg20684491 chr1:25596433 NA -0.37 -5.81 -0.3 1.47e-8 Erythrocyte sedimentation rate; LUSC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs12900413 0.687 rs12908468 chr15:90304236 T/G cg24249390 chr15:90295951 MESP1 -0.38 -5.85 -0.3 1.17e-8 Coronary artery aneurysm in Kawasaki disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12506373 chr2:27440548 CAD 0.5 7.26 0.37 2.81e-12 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg25036284 chr2:26402008 FAM59B -0.71 -9.84 -0.47 3.19e-20 Gut microbiome composition (summer); LUSC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg09034736 chr1:150693464 HORMAD1 0.48 7.07 0.36 9.34e-12 Tonsillectomy; LUSC cis rs716595 1.000 rs17127166 chr10:111989325 C/T cg13996003 chr10:112034540 MXI1 -0.67 -5.88 -0.31 9.89e-9 Normalized brain volume; LUSC cis rs7215564 0.730 rs34405143 chr17:78585681 G/C cg23238734 chr17:78661607 RPTOR 0.49 5.94 0.31 7.19e-9 Myopia (pathological); LUSC cis rs5771225 0.563 rs738334 chr22:50688235 T/C cg16473166 chr22:50639996 SELO 0.61 8.07 0.4 1.33e-14 Late-onset Alzheimer's disease; LUSC cis rs6084875 0.840 rs2422942 chr20:4726116 A/G cg26097573 chr20:4721490 PRNT -0.31 -5.74 -0.3 2.16e-8 Systemic lupus erythematosus; LUSC cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.07 0.48 5.33e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg23625390 chr15:77176239 SCAPER 0.52 7.98 0.4 2.38e-14 Blood metabolite levels; LUSC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg11266682 chr4:10021025 SLC2A9 0.6 11.01 0.52 2.92e-24 Bone mineral density; LUSC cis rs2742234 0.503 rs1254968 chr10:43691691 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 7.03 0.36 1.17e-11 Hirschsprung disease; LUSC cis rs6964587 1.000 rs6953515 chr7:91658620 C/T cg22709100 chr7:91322751 NA 0.43 6.25 0.32 1.24e-9 Breast cancer; LUSC cis rs77633900 0.614 rs279997 chr15:76949262 T/C cg21673338 chr15:77095150 SCAPER -0.77 -7.74 -0.39 1.2e-13 Non-glioblastoma glioma;Glioma; LUSC cis rs6681460 0.634 rs994396 chr1:67012236 G/A cg02459107 chr1:67143332 SGIP1 0.38 6.12 0.32 2.62e-9 Presence of antiphospholipid antibodies; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg17541715 chr7:1216824 NA -0.4 -6.26 -0.32 1.19e-9 Longevity;Endometriosis; LUSC cis rs951366 0.844 rs823096 chr1:205679887 G/T cg24503407 chr1:205819492 PM20D1 0.87 16.51 0.67 3.53e-45 Menarche (age at onset); LUSC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg17077180 chr1:38461687 NA -0.43 -6.18 -0.32 1.91e-9 Coronary artery disease; LUSC cis rs929354 0.742 rs7785227 chr7:156999297 C/T cg05182265 chr7:156933206 UBE3C -0.6 -9.63 -0.47 1.59e-19 Body mass index; LUSC cis rs317689 0.959 rs317688 chr12:69726850 T/C cg20891283 chr12:69753455 YEATS4 0.54 7.21 0.37 3.71e-12 Response to diuretic therapy; LUSC cis rs7833986 0.501 rs72653986 chr8:57035048 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.73 12.0 0.55 7.65e-28 Height; LUSC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg24324837 chr19:49891574 CCDC155 0.53 7.29 0.37 2.33e-12 Multiple sclerosis; LUSC trans rs17169634 1.000 rs73329116 chr7:34055590 T/C cg18512313 chr14:70700886 NA 0.59 5.98 0.31 5.6e-9 Alzheimer's disease; LUSC cis rs2404602 0.569 rs2469249 chr15:76772062 C/T cg23625390 chr15:77176239 SCAPER -0.53 -7.34 -0.37 1.63e-12 Blood metabolite levels; LUSC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC trans rs6582630 0.502 rs11520261 chr12:38332019 T/G cg06521331 chr12:34319734 NA -0.4 -6.21 -0.32 1.6e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg02017074 chr12:117425053 FBXW8 -0.69 -7.93 -0.4 3.43e-14 Subcortical brain region volumes;Hippocampal volume; LUSC trans rs7824557 0.701 rs2060465 chr8:11162609 T/C cg15556689 chr8:8085844 FLJ10661 0.54 8.26 0.41 3.34e-15 Retinal vascular caliber; LUSC cis rs1538970 0.924 rs12097497 chr1:45880669 C/T cg05343316 chr1:45956843 TESK2 0.65 9.04 0.44 1.28e-17 Platelet count; LUSC cis rs34779708 0.931 rs12776390 chr10:35391535 T/G cg04310649 chr10:35416472 CREM -0.43 -6.62 -0.34 1.45e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs61931739 0.513 rs1608906 chr12:33894986 T/C cg13010199 chr12:38710504 ALG10B 0.46 7.07 0.36 9.3e-12 Morning vs. evening chronotype; LUSC trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs6964587 1.000 rs4265 chr7:91719608 A/G cg22709100 chr7:91322751 NA -0.39 -5.75 -0.3 1.99e-8 Breast cancer; LUSC cis rs4555082 0.874 rs28785556 chr14:105745388 A/T cg06808227 chr14:105710500 BRF1 -0.64 -9.34 -0.46 1.37e-18 Mean platelet volume;Platelet distribution width; LUSC cis rs7267979 0.903 rs6115118 chr20:25246734 G/A cg08601574 chr20:25228251 PYGB 0.47 7.29 0.37 2.28e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9733 0.650 rs9803935 chr1:150552622 T/G cg13175981 chr1:150552382 MCL1 0.53 7.4 0.38 1.09e-12 Tonsillectomy; LUSC cis rs737337 0.623 rs3810308 chr19:11333596 T/C cg00586551 chr19:11347513 LOC55908;DOCK6 0.55 6.77 0.35 5.74e-11 HDL cholesterol;HDL cholesterol levels; LUSC cis rs3857067 0.806 rs7654919 chr4:95136164 C/T cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.32 -0.33 8.37e-10 QT interval; LUSC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg12963246 chr6:28129442 ZNF389 0.52 7.17 0.37 4.94e-12 Parkinson's disease; LUSC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg22535103 chr8:58192502 C8orf71 -0.57 -6.74 -0.35 6.81e-11 Developmental language disorder (linguistic errors); LUSC cis rs1801251 1.000 rs36007169 chr2:233621834 A/G cg08000102 chr2:233561755 GIGYF2 0.69 11.59 0.54 2.57e-26 Coronary artery disease; LUSC cis rs6541297 0.702 rs4846904 chr1:230279410 G/A cg05784532 chr1:230284198 GALNT2 0.49 7.39 0.38 1.16e-12 Coronary artery disease; LUSC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg02569458 chr12:86230093 RASSF9 -0.47 -7.97 -0.4 2.6e-14 Major depressive disorder; LUSC cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg19077165 chr18:44547161 KATNAL2 -0.42 -6.42 -0.33 4.78e-10 Personality dimensions; LUSC cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg23029597 chr12:123009494 RSRC2 -0.75 -9.63 -0.47 1.61e-19 Body mass index; LUSC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg22442454 chr1:209979470 IRF6 0.44 5.95 0.31 6.65e-9 Cleft lip with or without cleft palate; LUSC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg21782813 chr7:2030301 MAD1L1 0.43 7.21 0.37 3.79e-12 Bipolar disorder and schizophrenia; LUSC cis rs10791323 0.517 rs1120246 chr11:133745212 G/A cg15485101 chr11:133734466 NA 0.35 6.27 0.32 1.1e-9 Childhood ear infection; LUSC cis rs11583043 1.000 rs6675353 chr1:101459625 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.42 5.93 0.31 7.54e-9 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs1577917 1.000 rs6940458 chr6:86644992 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.26 -0.41 3.4e-15 Response to antipsychotic treatment; LUSC cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg11266682 chr4:10021025 SLC2A9 -0.51 -9.07 -0.44 1.05e-17 Bone mineral density; LUSC cis rs9303401 0.659 rs17222523 chr17:56620501 A/G cg25039879 chr17:56429692 SUPT4H1 0.69 9.14 0.45 6.35e-18 Cognitive test performance; LUSC cis rs7927771 0.524 rs10458915 chr11:47864392 T/A cg20307385 chr11:47447363 PSMC3 0.46 6.72 0.34 8.08e-11 Subjective well-being; LUSC cis rs12579753 0.871 rs1922540 chr12:82197496 A/G cg21231944 chr12:82153410 PPFIA2 -0.38 -5.85 -0.3 1.15e-8 Resting heart rate; LUSC cis rs314370 0.951 rs12705095 chr7:100484381 T/G cg08558340 chr7:100472263 SRRT 0.51 6.37 0.33 6.41e-10 Resting heart rate; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg24703941 chr19:36036726 TMEM147 0.44 6.14 0.32 2.28e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg15112475 chr7:1198522 ZFAND2A -0.35 -7.29 -0.37 2.3e-12 Longevity;Endometriosis; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg01802117 chr1:53393560 SCP2 0.4 6.53 0.34 2.44e-10 Monocyte count; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02010894 chr19:16653629 CHERP 0.48 6.48 0.33 3.37e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3744061 0.557 rs4544269 chr17:74648646 G/A cg27546012 chr17:74684504 MXRA7 -0.38 -6.55 -0.34 2.2e-10 Retinal arteriolar caliber; LUSC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11644478 chr21:40555479 PSMG1 -0.75 -13.15 -0.58 4.2e-32 Cognitive function; LUSC cis rs7681440 0.647 rs1442136 chr4:90819026 C/T cg20003494 chr4:90757398 SNCA 0.35 5.67 0.3 3.17e-8 Dementia with Lewy bodies; LUSC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg21724239 chr8:58056113 NA 0.57 6.61 0.34 1.56e-10 Developmental language disorder (linguistic errors); LUSC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg20503657 chr10:835505 NA 0.97 13.39 0.59 4.87e-33 Eosinophil percentage of granulocytes; LUSC cis rs1577917 0.916 rs12198730 chr6:86555138 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.77 -0.43 9.17e-17 Response to antipsychotic treatment; LUSC cis rs9457247 0.663 rs1894603 chr6:167434686 C/T cg07741184 chr6:167504864 NA -0.35 -6.41 -0.33 5.07e-10 Crohn's disease; LUSC trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.29 0.37 2.24e-12 Platelet count; LUSC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.33 0.53 2.1e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg21573476 chr21:45109991 RRP1B -0.36 -5.67 -0.3 3.13e-8 Mean corpuscular volume; LUSC cis rs1215050 0.791 rs2123100 chr4:98803747 T/C cg05340658 chr4:99064831 C4orf37 0.44 7.02 0.36 1.28e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs5758511 0.680 rs5758681 chr22:42645091 A/G cg00645731 chr22:42541494 CYP2D7P1 0.54 9.44 0.46 6.53e-19 Birth weight; LUSC cis rs12188164 0.502 rs55929184 chr5:405576 G/A cg00049323 chr5:472564 LOC25845 -0.41 -6.16 -0.32 2.04e-9 Cystic fibrosis severity; LUSC cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.71e-9 Body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19850565 chr19:35168394 ZNF302 0.49 6.87 0.35 3.12e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1178127 0.580 rs1178168 chr7:18792822 A/G cg02370815 chr7:18831390 HDAC9 -0.38 -5.74 -0.3 2.09e-8 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); LUSC cis rs17253792 0.822 rs77420254 chr14:56069646 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.96 -0.36 1.81e-11 Putamen volume; LUSC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg02807482 chr3:125708958 NA -0.52 -6.49 -0.33 3.08e-10 Blood pressure (smoking interaction); LUSC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.64 14.16 0.61 5.81e-36 Hemoglobin concentration; LUSC cis rs372883 0.648 rs382732 chr21:30719010 A/G cg24692254 chr21:30365293 RNF160 0.62 9.18 0.45 4.55e-18 Pancreatic cancer; LUSC cis rs7582720 1.000 rs114110842 chr2:203823400 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.19 0.41 5.42e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs3733585 0.673 rs4560411 chr4:9953361 A/G cg26043149 chr18:55253948 FECH -0.45 -6.9 -0.35 2.59e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.5 7.17 0.37 4.93e-12 Colorectal cancer; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg12968540 chr22:41572924 EP300 0.41 6.31 0.33 8.85e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.0 -0.31 5.03e-9 Menopause (age at onset); LUSC cis rs16867321 0.639 rs12466770 chr2:181441312 C/G cg23363182 chr2:181467187 NA 0.57 9.2 0.45 4.03e-18 Obesity; LUSC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.88 -10.95 -0.51 4.72e-24 Schizophrenia; LUSC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg06636001 chr8:8085503 FLJ10661 0.63 10.36 0.49 5.45e-22 Mood instability; LUSC cis rs4786125 0.636 rs11644404 chr16:6904030 C/A cg03623568 chr16:6915990 A2BP1 -0.49 -7.74 -0.39 1.23e-13 Heart rate variability traits (SDNN); LUSC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg26566898 chr11:117069891 TAGLN 0.46 8.33 0.41 2.12e-15 Blood protein levels; LUSC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg15448220 chr1:150897856 SETDB1 0.38 5.69 0.3 2.84e-8 Tonsillectomy; LUSC cis rs738321 0.757 rs6001020 chr22:38538246 C/G cg25457927 chr22:38595422 NA -0.31 -5.79 -0.3 1.62e-8 Breast cancer; LUSC cis rs826838 0.616 rs10880754 chr12:38628154 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.46 -0.42 8.73e-16 Heart rate; LUSC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 12.99 0.58 1.61e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg01616529 chr11:638424 DRD4 -0.34 -5.8 -0.3 1.58e-8 Systemic lupus erythematosus; LUSC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg12311346 chr5:56204834 C5orf35 -0.58 -8.5 -0.42 6.41e-16 Coronary artery disease; LUSC cis rs6456156 0.586 rs2001114 chr6:167486578 A/G cg06454157 chr6:167490870 NA -0.28 -6.58 -0.34 1.78e-10 Primary biliary cholangitis; LUSC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg06022373 chr22:39101656 GTPBP1 0.81 12.61 0.57 4.24e-30 Menopause (age at onset); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25453430 chr21:37433068 SETD4 -0.42 -6.23 -0.32 1.41e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs853679 0.607 rs13199649 chr6:27868792 C/T cg01620082 chr3:125678407 NA -0.83 -7.16 -0.36 5.24e-12 Depression; LUSC cis rs7674212 0.531 rs4699048 chr4:103926727 A/G cg16532752 chr4:104119610 CENPE -0.41 -5.67 -0.3 3.14e-8 Type 2 diabetes; LUSC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg19717773 chr7:2847554 GNA12 -0.4 -7.3 -0.37 2.06e-12 Height; LUSC cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg05283184 chr6:79620031 NA -0.57 -12.2 -0.56 1.41e-28 Intelligence (multi-trait analysis); LUSC cis rs2282802 0.685 rs13170475 chr5:139671062 C/T cg26211634 chr5:139558579 C5orf32 0.4 7.62 0.38 2.58e-13 Intelligence (multi-trait analysis); LUSC cis rs981844 1.000 rs2579917 chr4:154652648 T/G cg14289246 chr4:154710475 SFRP2 0.54 6.77 0.35 5.92e-11 Response to statins (LDL cholesterol change); LUSC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg09491104 chr22:46646882 C22orf40 -0.67 -7.08 -0.36 8.7e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs864537 0.676 rs3108155 chr1:167422057 C/G cg09179987 chr1:167433047 CD247 0.37 6.06 0.31 3.71e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC trans rs10432489 0.708 rs12693263 chr2:181740210 A/G cg00055848 chr2:62422984 B3GNT2 -0.91 -6.16 -0.32 2.13e-9 QT interval; LUSC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg04673462 chr1:38461896 NA -0.54 -7.83 -0.39 6.51e-14 Coronary artery disease; LUSC cis rs7512552 0.839 rs1694369 chr1:150351101 A/G cg15654264 chr1:150340011 RPRD2 0.67 11.18 0.52 7.2e-25 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1055129 0.560 rs56248937 chr17:73915153 T/A cg19302996 chr17:73780495 UNK -0.49 -7.08 -0.36 8.35e-12 White matter hyperintensity burden; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17001531 chr1:16825540 NA -0.5 -6.53 -0.34 2.5e-10 Bipolar disorder and schizophrenia; LUSC cis rs57549656 0.659 rs72980733 chr19:2711316 G/C cg06609049 chr19:2785107 THOP1 0.49 6.19 0.32 1.75e-9 Schizophrenia; LUSC cis rs9677476 0.731 rs1477470 chr2:232076724 A/C cg07929768 chr2:232055508 NA 0.37 7.03 0.36 1.15e-11 Food antigen IgG levels; LUSC cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC trans rs2797160 1.000 rs1418642 chr6:125999768 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.68 -0.34 1.03e-10 Endometrial cancer; LUSC cis rs6964587 0.934 rs73226382 chr7:91692760 T/C cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.26e-18 Breast cancer; LUSC cis rs2742417 1.000 rs1534876 chr3:45741257 G/T cg18779283 chr3:45636154 LIMD1 -0.34 -5.88 -0.31 9.79e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg05043794 chr9:111880884 C9orf5 0.34 7.56 0.38 4.02e-13 Menarche (age at onset); LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg22166914 chr1:53195759 ZYG11B -0.49 -7.76 -0.39 1.04e-13 Monocyte count; LUSC cis rs3087591 0.960 rs2952999 chr17:29509801 G/T cg24425628 chr17:29625626 OMG;NF1 0.56 8.11 0.41 9.79e-15 Hip circumference; LUSC cis rs9800506 0.866 rs6931945 chr6:35525751 C/T cg03566752 chr6:35512600 NA 0.25 6.1 0.32 2.89e-9 Neutrophil percentage of granulocytes; LUSC cis rs17818399 0.712 rs13008088 chr2:46781580 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -6.77 -0.35 5.71e-11 Height; LUSC cis rs4786125 0.512 rs55694271 chr16:6930378 G/A cg03623568 chr16:6915990 A2BP1 -0.48 -7.79 -0.39 8.49e-14 Heart rate variability traits (SDNN); LUSC cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06022373 chr22:39101656 GTPBP1 0.73 11.11 0.52 1.34e-24 Menopause (age at onset); LUSC cis rs4304924 0.500 rs2281856 chr13:79207644 C/T cg07926092 chr13:79233506 RNF219 -0.46 -5.76 -0.3 1.92e-8 Large artery stroke; LUSC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg11062466 chr8:58055876 NA 0.47 5.98 0.31 5.85e-9 Developmental language disorder (linguistic errors); LUSC trans rs11098499 0.954 rs12508504 chr4:120410607 A/C cg25214090 chr10:38739885 LOC399744 0.54 8.12 0.41 9.19e-15 Corneal astigmatism; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.61 10.11 0.48 3.76e-21 Lymphocyte counts; LUSC cis rs782590 0.967 rs17798852 chr2:55805172 A/C cg18811423 chr2:55921094 PNPT1 0.83 14.27 0.62 2.16e-36 Metabolic syndrome; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.81 -15.23 -0.64 3.85e-40 Prudent dietary pattern; LUSC cis rs9788682 0.747 rs28511883 chr15:78783683 C/T cg24631222 chr15:78858424 CHRNA5 0.64 8.37 0.42 1.62e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs3092073 0.624 rs3848714 chr20:44547176 T/C cg27529037 chr20:44575021 PCIF1 0.39 6.76 0.35 6.33e-11 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg18230493 chr5:56204884 C5orf35 -0.94 -13.79 -0.6 1.43e-34 Initial pursuit acceleration; LUSC trans rs459571 0.959 rs2810491 chr9:136923331 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 0.74 12.3 0.56 6e-29 Platelet distribution width; LUSC cis rs9355610 0.609 rs62436424 chr6:167374258 A/G cg23791538 chr6:167370224 RNASET2 0.41 5.86 0.31 1.12e-8 Graves' disease; LUSC cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.82 -10.36 -0.49 5.5e-22 Chronic sinus infection; LUSC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg00310523 chr12:86230176 RASSF9 0.51 9.71 0.47 8.41e-20 Major depressive disorder; LUSC trans rs61931739 0.534 rs11053047 chr12:34161084 C/T cg13010199 chr12:38710504 ALG10B 0.54 8.45 0.42 9.43e-16 Morning vs. evening chronotype; LUSC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg19592336 chr6:28129416 ZNF389 0.53 7.13 0.36 6.34e-12 Parkinson's disease; LUSC cis rs412000 0.507 rs2680688 chr17:56450524 T/C cg12560992 chr17:57184187 TRIM37 -0.43 -6.61 -0.34 1.51e-10 Primary tooth development (time to first tooth eruption); LUSC trans rs9630182 0.561 rs12802900 chr11:13437923 C/A cg00234616 chr2:74740572 TLX2 0.31 5.98 0.31 5.68e-9 Bone mineral density; LUSC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg16744531 chr19:17905626 B3GNT3 0.43 6.48 0.33 3.31e-10 Tumor biomarkers; LUSC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg05585544 chr11:47624801 NA -0.44 -7.66 -0.39 1.99e-13 Subjective well-being; LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg06145435 chr7:1022769 CYP2W1 0.29 6.14 0.32 2.36e-9 Longevity;Endometriosis; LUSC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.8 11.0 0.52 3.16e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs55883249 1.000 rs75139639 chr2:9763905 A/T cg23886495 chr2:9695866 ADAM17 0.51 6.12 0.32 2.59e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs868036 0.681 rs13329567 chr15:68104367 C/T cg05925327 chr15:68127851 NA -0.4 -6.4 -0.33 5.35e-10 Restless legs syndrome; LUSC cis rs738322 0.935 rs133014 chr22:38571087 T/G cg17652424 chr22:38574118 PLA2G6 -0.29 -6.41 -0.33 5e-10 Cutaneous nevi; LUSC cis rs727505 1.000 rs6952721 chr7:124480075 T/C cg23710748 chr7:124431027 NA -0.4 -7.24 -0.37 3.06e-12 Lewy body disease; LUSC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg19622623 chr12:86230825 RASSF9 -0.41 -5.71 -0.3 2.44e-8 Major depressive disorder; LUSC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg15448220 chr1:150897856 SETDB1 0.43 6.38 0.33 5.75e-10 Melanoma; LUSC trans rs6089829 0.962 rs4586690 chr20:61658595 G/T cg13615516 chr5:77269221 NA 0.4 6.56 0.34 2.02e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs10761482 0.728 rs4290174 chr10:62104583 C/G cg18175470 chr10:62150864 ANK3 -0.49 -7.07 -0.36 9.31e-12 Schizophrenia; LUSC cis rs6500395 0.962 rs1039341 chr16:48574869 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.52 0.34 2.66e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7312933 0.558 rs1796382 chr12:42840955 C/G cg01256987 chr12:42539512 GXYLT1 0.34 6.19 0.32 1.79e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg05861140 chr6:150128134 PCMT1 -0.44 -7.04 -0.36 1.1e-11 Lung cancer; LUSC cis rs477692 0.905 rs693402 chr10:131422882 G/A cg11019008 chr10:131425282 MGMT 0.41 6.28 0.32 1.08e-9 Response to temozolomide; LUSC cis rs12519773 0.501 rs4449514 chr5:92521022 T/C cg18783429 chr5:92414398 NA 0.34 7.38 0.37 1.28e-12 Migraine; LUSC cis rs2839186 0.967 rs4819222 chr21:47707778 G/A cg12379764 chr21:47803548 PCNT -0.42 -5.89 -0.31 9.57e-9 Testicular germ cell tumor; LUSC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg10802521 chr3:52805072 NEK4 -0.53 -8.47 -0.42 8.16e-16 Bipolar disorder; LUSC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg17330251 chr7:94953956 PON1 -0.38 -5.97 -0.31 6.02e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs6460942 0.630 rs62448731 chr7:12341174 G/A cg06484146 chr7:12443880 VWDE -0.58 -6.24 -0.32 1.36e-9 Coronary artery disease; LUSC trans rs2797160 1.000 rs1739362 chr6:126020703 A/T cg05039488 chr6:79577232 IRAK1BP1 0.46 6.95 0.36 1.88e-11 Endometrial cancer; LUSC cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg01528321 chr10:82214614 TSPAN14 0.59 8.48 0.42 7.37e-16 Post bronchodilator FEV1; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10884867 chr2:74618939 LOC100189589 -0.43 -6.4 -0.33 5.22e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.22e-21 Electroencephalogram traits; LUSC cis rs9300255 0.602 rs1727314 chr12:123640664 C/A cg00376283 chr12:123451042 ABCB9 0.67 8.42 0.42 1.1e-15 Neutrophil percentage of white cells; LUSC cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg01973587 chr1:228161476 NA 0.46 8.31 0.41 2.49e-15 Diastolic blood pressure; LUSC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg14829155 chr15:31115871 NA -0.57 -7.96 -0.4 2.7e-14 Huntington's disease progression; LUSC cis rs10911251 0.546 rs1062044 chr1:183112412 A/G ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC cis rs654950 0.806 rs1535505 chr1:42026152 A/G cg06885757 chr1:42089581 HIVEP3 0.41 7.79 0.39 8.68e-14 Airway imaging phenotypes; LUSC trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg03929089 chr4:120376271 NA 0.87 12.21 0.56 1.39e-28 Coronary artery disease; LUSC cis rs1003719 0.667 rs13050226 chr21:38457708 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 9.35 0.46 1.26e-18 Eye color traits; LUSC cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg03146154 chr1:46216737 IPP -0.51 -7.44 -0.38 8.45e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1865760 0.566 rs2032443 chr6:26046802 A/G cg17691542 chr6:26056736 HIST1H1C 0.52 7.7 0.39 1.56e-13 Height; LUSC cis rs55665837 1.000 rs12804549 chr11:14437758 A/T cg19336497 chr11:14380999 RRAS2 -0.36 -7.41 -0.38 1.04e-12 Vitamin D levels; LUSC cis rs727505 0.607 rs67313231 chr7:124804532 T/A cg23710748 chr7:124431027 NA -0.36 -6.27 -0.32 1.11e-9 Lewy body disease; LUSC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg12463550 chr7:65579703 CRCP 0.52 7.46 0.38 7.59e-13 Aortic root size; LUSC cis rs40363 0.523 rs757270 chr16:3534451 C/T cg00484396 chr16:3507460 NAT15 -0.65 -10.93 -0.51 5.53e-24 Tuberculosis; LUSC cis rs6845621 0.727 rs28791037 chr4:18909682 G/T cg12196642 chr4:18937545 NA -0.33 -6.27 -0.32 1.1e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs634534 0.622 rs593525 chr11:65727799 T/C cg26695010 chr11:65641043 EFEMP2 -0.48 -7.2 -0.37 4.05e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs6121246 0.559 rs6060944 chr20:30372114 G/A cg13852791 chr20:30311386 BCL2L1 0.94 14.73 0.63 3.46e-38 Mean corpuscular hemoglobin; LUSC cis rs79387448 0.745 rs79107058 chr2:103164257 C/A cg09003973 chr2:102972529 NA 0.88 8.56 0.42 4.18e-16 Gut microbiota (bacterial taxa); LUSC cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg26384229 chr12:38710491 ALG10B 0.88 14.67 0.63 6.03e-38 Bladder cancer; LUSC cis rs9650315 0.866 rs13248165 chr8:57192842 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.54 7.02 0.36 1.21e-11 Height; LUSC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg21852757 chr3:179424616 USP13 -0.45 -7.78 -0.39 9.25e-14 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg13319975 chr6:146136371 FBXO30 0.49 7.47 0.38 7.15e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2658782 0.789 rs2259633 chr11:93141580 C/A cg15737290 chr11:93063684 CCDC67 0.64 7.96 0.4 2.78e-14 Pulmonary function decline; LUSC cis rs1538970 0.962 rs9429077 chr1:45820667 C/A cg05343316 chr1:45956843 TESK2 0.62 8.7 0.43 1.55e-16 Platelet count; LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 15.62 0.65 1.12e-41 Platelet count; LUSC cis rs6754311 0.593 rs1446584 chr2:136419961 C/T cg07169764 chr2:136633963 MCM6 -0.57 -7.63 -0.39 2.41e-13 Mosquito bite size; LUSC cis rs11190604 1.000 rs57025426 chr10:102205868 A/G cg07080220 chr10:102295463 HIF1AN 0.63 8.28 0.41 2.95e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9297145 0.565 rs941001 chr7:98735185 A/T cg05967295 chr7:98741636 SMURF1 -0.66 -10.59 -0.5 8.87e-23 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs2204008 0.539 rs1283295 chr12:38146014 A/C cg13010199 chr12:38710504 ALG10B -0.52 -7.86 -0.39 5.45e-14 Bladder cancer; LUSC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg20135002 chr11:47629003 NA 0.48 7.46 0.38 7.41e-13 Subjective well-being; LUSC cis rs7103648 0.669 rs7927445 chr11:47780754 G/T cg20307385 chr11:47447363 PSMC3 0.81 12.4 0.56 2.75e-29 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg17719053 chr1:75198211 TYW3;CRYZ 0.39 6.31 0.33 8.67e-10 Resistin levels; LUSC cis rs1670533 1.000 rs7679432 chr4:1050521 G/A cg16405210 chr4:1374714 KIAA1530 -0.46 -5.71 -0.3 2.44e-8 Recombination rate (females); LUSC cis rs1005277 1.000 rs1005277 chr10:38218259 A/C cg25427524 chr10:38739819 LOC399744 0.51 7.44 0.38 8.74e-13 Extrinsic epigenetic age acceleration; LUSC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg08499158 chr17:42289980 UBTF 0.4 6.21 0.32 1.55e-9 Total body bone mineral density; LUSC cis rs7666738 0.716 rs6827474 chr4:99089683 T/G cg17366294 chr4:99064904 C4orf37 0.53 9.15 0.45 5.58e-18 Colonoscopy-negative controls vs population controls; LUSC cis rs939574 1.000 rs11689596 chr2:220093423 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.95 -8.25 -0.41 3.82e-15 Platelet distribution width; LUSC cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg23625390 chr15:77176239 SCAPER 0.39 5.66 0.3 3.26e-8 Blood metabolite levels; LUSC cis rs6563842 0.572 rs9549263 chr13:41264784 G/T cg21288729 chr13:41239152 FOXO1 0.56 8.31 0.41 2.4e-15 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15572692 chr19:14016919 C19orf57;CC2D1A -0.41 -6.07 -0.32 3.57e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg19318889 chr4:1322082 MAEA 0.54 8.97 0.44 2.1e-17 Obesity-related traits; LUSC cis rs7705502 0.926 rs72812804 chr5:173340496 T/G cg18693985 chr5:173351052 CPEB4 -0.36 -5.79 -0.3 1.63e-8 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7587476 0.784 rs13032278 chr2:215698034 G/A cg04004882 chr2:215674386 BARD1 0.49 6.44 0.33 4.06e-10 Neuroblastoma; LUSC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.01 -0.31 4.96e-9 Total body bone mineral density; LUSC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg00409905 chr10:38381863 ZNF37A -0.38 -6.41 -0.33 4.94e-10 Extrinsic epigenetic age acceleration; LUSC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg05872129 chr22:39784769 NA -0.57 -10.57 -0.5 1.02e-22 Intelligence (multi-trait analysis); LUSC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg11764359 chr7:65958608 NA 0.81 13.6 0.6 7.98e-34 Aortic root size; LUSC cis rs9807989 0.839 rs10204837 chr2:102977730 C/A cg03938978 chr2:103052716 IL18RAP 0.31 5.74 0.3 2.08e-8 Asthma; LUSC cis rs250677 0.687 rs250672 chr5:148446110 A/G cg18129178 chr5:148520854 ABLIM3 -0.69 -10.62 -0.5 6.72e-23 Breast cancer; LUSC cis rs6496667 0.558 rs10459677 chr15:91042399 A/C cg22089800 chr15:90895588 ZNF774 -0.56 -8.0 -0.4 2e-14 Rheumatoid arthritis; LUSC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg27535305 chr1:53392650 SCP2 -0.39 -7.36 -0.37 1.43e-12 Monocyte count; LUSC trans rs1559759 0.736 rs11032995 chr11:35111292 A/G cg10143416 chr2:241907034 NA 0.45 6.23 0.32 1.38e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg06544989 chr22:39130855 UNC84B 0.34 6.01 0.31 4.93e-9 Menopause (age at onset); LUSC cis rs9467773 1.000 rs6910899 chr6:26524339 A/G cg09904177 chr6:26538194 HMGN4 0.75 14.34 0.62 1.18e-36 Intelligence (multi-trait analysis); LUSC cis rs1385374 0.698 rs2170988 chr12:129290876 A/C cg09035930 chr12:129282057 SLC15A4 -0.64 -6.78 -0.35 5.5e-11 Systemic lupus erythematosus; LUSC cis rs4234798 0.500 rs7661077 chr4:7219889 C/T cg18431297 chr4:7219810 SORCS2 0.32 5.99 0.31 5.46e-9 Insulin-like growth factors; LUSC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.55 7.57 0.38 3.63e-13 Multiple sclerosis; LUSC cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg04455712 chr21:45112962 RRP1B 0.46 8.92 0.44 3.06e-17 Mean corpuscular volume; LUSC cis rs9467773 1.000 rs2255070 chr6:26501777 C/G cg11502198 chr6:26597334 ABT1 0.6 9.22 0.45 3.34e-18 Intelligence (multi-trait analysis); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14288330 chr14:36003208 INSM2 0.44 6.12 0.32 2.64e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2688608 0.620 rs7080350 chr10:75577843 A/G cg23231163 chr10:75533350 FUT11 0.44 7.26 0.37 2.79e-12 Inflammatory bowel disease; LUSC cis rs7312933 0.585 rs7969814 chr12:42669657 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.51 7.3 0.37 2.17e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs7181230 1.000 rs9972424 chr15:40365851 A/G cg22705835 chr10:65332833 REEP3 -0.43 -7.37 -0.37 1.32e-12 Dehydroepiandrosterone sulphate levels; LUSC cis rs9815354 1.000 rs17062109 chr3:41810364 C/T cg03022575 chr3:42003672 ULK4 0.52 5.86 0.31 1.12e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg19418458 chr7:158789849 NA -0.54 -8.62 -0.43 2.72e-16 Facial morphology (factor 20); LUSC cis rs3806843 0.568 rs2530232 chr5:140082878 A/G cg26395211 chr5:140044315 WDR55 0.46 6.91 0.35 2.42e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg22166914 chr1:53195759 ZYG11B 0.62 10.3 0.49 8.51e-22 Monocyte count; LUSC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg00129232 chr17:37814104 STARD3 -0.44 -6.32 -0.33 8.34e-10 Asthma; LUSC cis rs8028313 0.529 rs16951358 chr15:68153732 G/C cg08079166 chr15:68083412 MAP2K5 0.31 5.76 0.3 1.9e-8 Obesity; LUSC cis rs11169225 0.724 rs7305290 chr12:50341465 A/G cg23855989 chr12:50355821 AQP5 0.6 10.72 0.51 3.14e-23 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg18681998 chr4:17616180 MED28 0.79 13.6 0.6 8.08e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg06064525 chr11:970664 AP2A2 -0.48 -10.53 -0.5 1.37e-22 Alzheimer's disease (late onset); LUSC cis rs2204008 0.527 rs8189480 chr12:38345648 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.0 -0.4 2.11e-14 Bladder cancer; LUSC cis rs2880765 0.566 rs12911430 chr15:86011264 A/T cg10818794 chr15:86012489 AKAP13 -0.42 -6.55 -0.34 2.13e-10 Coronary artery disease; LUSC cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg20908204 chr19:46285434 DMPK 0.43 8.46 0.42 8.69e-16 Coronary artery disease; LUSC cis rs17255340 0.539 rs1144193 chr6:83979034 A/G cg08257003 chr6:84140564 ME1 0.32 8.13 0.41 8.21e-15 Platelet-derived growth factor BB levels; LUSC cis rs62064224 0.703 rs62065493 chr17:30822620 C/G cg18200150 chr17:30822561 MYO1D 0.53 10.55 0.5 1.17e-22 Schizophrenia; LUSC cis rs11191270 0.554 rs77616533 chr10:104055983 A/G cg15320455 chr10:103880129 LDB1 0.6 6.17 0.32 1.99e-9 Intelligence (multi-trait analysis); LUSC cis rs2835872 0.663 rs73220488 chr21:38987025 C/T cg20424643 chr21:39039972 KCNJ6 0.37 5.71 0.3 2.51e-8 Electroencephalographic traits in alcoholism; LUSC cis rs6709815 0.841 rs12694442 chr2:219663599 T/C cg02176678 chr2:219576539 TTLL4 -0.52 -9.12 -0.45 7.39e-18 Reticulocyte count;High light scatter reticulocyte count; LUSC cis rs7582720 1.000 rs72934563 chr2:203995405 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.83 8.78 0.43 8.34e-17 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg08847533 chr14:75593920 NEK9 0.84 15.46 0.65 4.83e-41 Height; LUSC cis rs3093024 1.000 rs3093024 chr6:167532793 C/T cg07741184 chr6:167504864 NA 0.5 9.09 0.45 9.21e-18 Rheumatoid arthritis; LUSC cis rs7075426 0.716 rs11598718 chr10:88294484 G/A cg07322936 chr10:88137208 NA 0.44 6.2 0.32 1.66e-9 Migraine without aura; LUSC cis rs76878669 0.561 rs1784029 chr11:66099987 C/T cg18002602 chr11:66138449 SLC29A2 0.45 8.2 0.41 5.14e-15 Educational attainment (years of education); LUSC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg02551604 chr5:131831745 NA 0.43 6.61 0.34 1.48e-10 Asthma (sex interaction); LUSC cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg01065977 chr19:18549689 ISYNA1 -0.23 -5.94 -0.31 7.06e-9 Breast cancer; LUSC cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg26647111 chr11:31128758 NA 0.42 6.14 0.32 2.4e-9 Red blood cell count; LUSC cis rs7267979 1.000 rs6138575 chr20:25438952 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.91 0.7 9.06e-51 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6076960 0.684 rs6038408 chr20:6268983 A/C cg21095983 chr6:86352623 SYNCRIP 0.57 8.83 0.44 6.02e-17 Smooth-surface caries; LUSC cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg27129171 chr3:47204927 SETD2 -0.68 -11.24 -0.52 4.52e-25 Colorectal cancer; LUSC trans rs1814175 0.817 rs11040700 chr11:50023832 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs10269783 0.651 rs2158546 chr7:49625671 C/A cg27385590 chr7:49619841 NA -0.31 -5.71 -0.3 2.47e-8 Body mass index; LUSC cis rs2522056 1.000 rs2522047 chr5:131795882 G/T cg24060327 chr5:131705240 SLC22A5 0.45 5.96 0.31 6.39e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.96 0.58 2.11e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs748404 0.697 rs546170 chr15:43564849 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.54 8.47 0.42 7.96e-16 Lung cancer; LUSC cis rs7582720 1.000 rs72932774 chr2:203685728 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.77 7.98 0.4 2.35e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs629535 0.514 rs55653755 chr8:70154383 A/C cg21567404 chr3:27674614 NA -0.93 -13.37 -0.59 5.88e-33 Dupuytren's disease; LUSC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -6.19 -0.32 1.78e-9 Self-reported allergy; LUSC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg25019033 chr10:957182 NA -0.5 -6.2 -0.32 1.69e-9 Eosinophil percentage of granulocytes; LUSC cis rs992157 0.965 rs13419763 chr2:219134950 C/T cg00012203 chr2:219082015 ARPC2 0.81 13.82 0.6 1.1e-34 Colorectal cancer; LUSC cis rs11018904 0.861 rs61903723 chr11:89968246 C/T cg26028595 chr11:89956573 CHORDC1 -0.53 -6.15 -0.32 2.22e-9 Intelligence (multi-trait analysis); LUSC cis rs7647973 1.000 rs1009051 chr3:49521549 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.54 0.38 4.44e-13 Menarche (age at onset); LUSC cis rs4285028 0.747 rs11928871 chr3:121483388 G/C cg11130432 chr3:121712080 ILDR1 -0.63 -9.29 -0.45 2.08e-18 Multiple sclerosis; LUSC cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.51e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg14552801 chr7:65878734 NA -0.46 -6.53 -0.34 2.45e-10 Aortic root size; LUSC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06022373 chr22:39101656 GTPBP1 0.73 11.26 0.52 3.72e-25 Menopause (age at onset); LUSC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg11663144 chr21:46675770 NA -0.41 -7.03 -0.36 1.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.5 7.57 0.38 3.58e-13 Prudent dietary pattern; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg18755547 chr17:556432 VPS53 0.46 6.25 0.32 1.26e-9 Hepatitis; LUSC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg18306943 chr3:40428807 ENTPD3 0.39 5.75 0.3 2.03e-8 Renal cell carcinoma; LUSC cis rs2204008 0.775 rs3900361 chr12:38238936 A/G cg13010199 chr12:38710504 ALG10B -0.65 -10.22 -0.49 1.61e-21 Bladder cancer; LUSC trans rs9329221 0.513 rs4841296 chr8:10105447 C/G cg21775007 chr8:11205619 TDH -0.43 -5.97 -0.31 6e-9 Neuroticism; LUSC cis rs9549367 0.789 rs34448227 chr13:113884754 A/C cg18105134 chr13:113819100 PROZ -0.67 -9.57 -0.46 2.49e-19 Platelet distribution width; LUSC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg05863683 chr7:1912471 MAD1L1 0.29 5.72 0.3 2.42e-8 Bipolar disorder and schizophrenia; LUSC cis rs6599077 1.000 rs2887952 chr3:40098229 G/C cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs2073300 1.000 rs6048824 chr20:23457645 C/A cg09953122 chr20:23471693 CST8 -0.69 -6.86 -0.35 3.28e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs11098499 0.865 rs10213221 chr4:120255926 G/A cg09307838 chr4:120376055 NA 0.69 10.49 0.5 1.88e-22 Corneal astigmatism; LUSC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.1 -0.48 4.24e-21 Platelet count; LUSC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.93e-11 Blood metabolite levels; LUSC cis rs1982963 1.000 rs3742536 chr14:52507429 C/T cg10843707 chr14:52510701 NID2 0.41 7.39 0.37 1.17e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.9 -11.86 -0.54 2.51e-27 Chronic sinus infection; LUSC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7759001 0.857 rs2223464 chr6:27356216 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.78 0.3 1.73e-8 Glomerular filtration rate (creatinine); LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg19318889 chr4:1322082 MAEA 0.54 9.01 0.44 1.66e-17 Longevity; LUSC cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg00101154 chr16:420108 MRPL28 -0.41 -6.47 -0.33 3.53e-10 Bone mineral density (spine);Bone mineral density; LUSC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.52 -8.02 -0.4 1.8e-14 Menarche (age at onset); LUSC cis rs911119 0.955 rs6048930 chr20:23592492 T/C cg16589663 chr20:23618590 CST3 0.57 6.79 0.35 5.12e-11 Chronic kidney disease; LUSC cis rs7223966 1.000 rs11657081 chr17:61792339 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 7.51 0.38 5.51e-13 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg19592336 chr6:28129416 ZNF389 0.47 6.19 0.32 1.75e-9 Depression; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg01881136 chr16:89438758 ANKRD11 -0.4 -6.41 -0.33 5.09e-10 Asthma; LUSC trans rs7939886 0.920 rs10896157 chr11:56037621 T/G cg15704280 chr7:45808275 SEPT13 0.86 6.54 0.34 2.26e-10 Myopia (pathological); LUSC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg02475777 chr4:1388615 CRIPAK 0.42 6.37 0.33 6.09e-10 Longevity; LUSC trans rs7615952 0.599 rs67575510 chr3:125742355 C/G cg07211511 chr3:129823064 LOC729375 -0.78 -9.97 -0.48 1.18e-20 Blood pressure (smoking interaction); LUSC trans rs7819412 0.522 rs11776603 chr8:11020313 G/T cg15556689 chr8:8085844 FLJ10661 -0.48 -6.49 -0.33 3.01e-10 Triglycerides; LUSC cis rs208520 0.690 rs851468 chr6:66825875 G/A cg07460842 chr6:66804631 NA -1.15 -18.29 -0.71 2.9e-52 Exhaled nitric oxide output; LUSC cis rs1335645 0.570 rs56740658 chr1:111647508 C/G cg00321911 chr1:111669324 DRAM2 -0.59 -6.16 -0.32 2.13e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg17294928 chr15:75287854 SCAMP5 -0.84 -11.42 -0.53 1.01e-25 Blood trace element (Zn levels); LUSC cis rs9311676 0.632 rs34086582 chr3:58419944 C/T cg13750441 chr3:58318267 PXK 0.35 6.83 0.35 4.14e-11 Systemic lupus erythematosus; LUSC cis rs10089 0.953 rs1036171 chr5:127402798 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.83 11.8 0.54 4.3e-27 Ileal carcinoids; LUSC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg23711669 chr6:146136114 FBXO30 0.88 16.37 0.67 1.21e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs6484504 0.576 rs16922084 chr11:31371109 C/T cg06552810 chr11:31128660 NA 0.39 6.77 0.35 5.78e-11 Red blood cell count; LUSC cis rs72960926 0.744 rs7755776 chr6:74967405 C/G cg03266952 chr6:74778945 NA 0.78 6.92 0.35 2.37e-11 Metabolite levels (MHPG); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10619042 chr17:66202065 NA -0.4 -6.07 -0.32 3.53e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg15596816 chr17:45501030 LOC100272146;C17orf57 0.35 5.95 0.31 6.73e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03865648 chr3:173113856 NA -0.43 -6.13 -0.32 2.52e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg11494091 chr17:61959527 GH2 0.64 13.71 0.6 2.91e-34 Prudent dietary pattern; LUSC trans rs11764590 0.715 rs9639202 chr7:2087315 G/A cg25206134 chr2:45395956 NA 0.56 6.15 0.32 2.2e-9 Neuroticism; LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg16145915 chr7:1198662 ZFAND2A -0.52 -10.12 -0.48 3.46e-21 Longevity;Endometriosis; LUSC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg02475777 chr4:1388615 CRIPAK 0.4 5.87 0.31 1.04e-8 Obesity-related traits; LUSC cis rs7589342 0.628 rs35866817 chr2:106402569 T/C cg14210321 chr2:106509881 NCK2 -0.46 -5.83 -0.3 1.3e-8 Addiction; LUSC trans rs7824557 0.564 rs2572399 chr8:11234520 A/G cg15556689 chr8:8085844 FLJ10661 -0.49 -7.51 -0.38 5.52e-13 Retinal vascular caliber; LUSC cis rs11997175 0.558 rs6468207 chr8:33798095 G/A ch.8.33884649F chr8:33765107 NA -0.43 -6.25 -0.32 1.26e-9 Body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18313702 chr3:183853126 EIF2B5 0.49 7.04 0.36 1.1e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1322512 0.917 rs2258722 chr6:152969710 C/T cg27316956 chr6:152958899 SYNE1 -0.36 -6.28 -0.32 1.07e-9 Tonometry; LUSC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg14789911 chr21:47582049 C21orf56 -0.4 -6.27 -0.32 1.1e-9 Testicular germ cell tumor; LUSC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.61 -0.34 1.55e-10 High light scatter reticulocyte count; LUSC cis rs9457247 0.967 rs387733 chr6:167409771 C/T cg25258033 chr6:167368657 RNASET2 -0.46 -7.62 -0.38 2.68e-13 Crohn's disease; LUSC cis rs7824557 0.564 rs35009431 chr8:11232788 G/A cg21775007 chr8:11205619 TDH -0.69 -10.93 -0.51 5.48e-24 Retinal vascular caliber; LUSC cis rs17270561 0.609 rs7754733 chr6:25745049 C/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.14 0.45 6.03e-18 Iron status biomarkers; LUSC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg25643088 chr3:52874325 TMEM110 -0.4 -6.01 -0.31 4.85e-9 Schizophrenia; LUSC cis rs1997103 1.000 rs6957984 chr7:55397331 G/A cg17469321 chr7:55412551 NA 0.65 10.58 0.5 9.39e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg23277830 chr1:3704460 LRRC47 0.3 5.85 0.3 1.16e-8 Red cell distribution width; LUSC cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.59 0.38 3.31e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11048434 0.736 rs1805724 chr12:9104609 T/C cg23795048 chr12:9217529 LOC144571 0.34 5.82 0.3 1.35e-8 Sjögren's syndrome; LUSC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg10802521 chr3:52805072 NEK4 -0.55 -9.19 -0.45 4.41e-18 Bipolar disorder; LUSC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg09359103 chr1:154839909 KCNN3 -0.69 -15.43 -0.65 6.29e-41 Prostate cancer; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg23505966 chr3:101443535 CEP97 0.39 5.95 0.31 6.59e-9 Calcium levels; LUSC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg26677194 chr12:130822605 PIWIL1 0.6 8.96 0.44 2.29e-17 Menopause (age at onset); LUSC cis rs9914988 1.000 rs9895443 chr17:27182944 A/G cg19789473 chr17:27170043 C17orf63 -0.3 -5.87 -0.31 1.04e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg12751644 chr20:60527061 NA -0.35 -6.11 -0.32 2.73e-9 Body mass index; LUSC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg05623727 chr3:50126028 RBM5 0.32 5.97 0.31 6.04e-9 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 8.48 0.42 7.15e-16 Prudent dietary pattern; LUSC cis rs354225 0.544 rs13391522 chr2:54805854 T/C cg26097391 chr2:54893211 SPTBN1 0.46 6.93 0.35 2.19e-11 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07050772 chr17:48423262 XYLT2 -0.39 -5.95 -0.31 6.62e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg11584989 chr19:19387371 SF4 0.59 6.99 0.36 1.46e-11 Bipolar disorder; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg11494091 chr17:61959527 GH2 0.65 13.74 0.6 2.37e-34 Prudent dietary pattern; LUSC cis rs5769707 0.642 rs135880 chr22:50018654 T/A cg07959070 chr22:50026188 C22orf34 -0.33 -6.3 -0.33 9.33e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg06108461 chr20:60628389 TAF4 -0.73 -11.65 -0.54 1.52e-26 Body mass index; LUSC cis rs7584330 0.554 rs74001399 chr2:238445440 G/A cg14458575 chr2:238380390 NA 0.43 5.66 0.3 3.31e-8 Prostate cancer; LUSC cis rs7584330 0.740 rs7586312 chr2:238439389 G/A cg14458575 chr2:238380390 NA 0.52 8.86 0.44 4.97e-17 Prostate cancer; LUSC cis rs7927592 0.913 rs67005337 chr11:68307758 A/C cg20283391 chr11:68216788 NA -0.61 -8.56 -0.42 4.24e-16 Total body bone mineral density; LUSC cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg08999081 chr20:33150536 PIGU -0.54 -10.53 -0.5 1.4e-22 Glomerular filtration rate (creatinine); LUSC trans rs6598955 0.671 rs75517917 chr1:26612926 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.52 -0.42 5.56e-16 Obesity-related traits; LUSC cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -13.64 -0.6 5.38e-34 Chronic sinus infection; LUSC cis rs11122272 0.668 rs2808616 chr1:231554993 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.64 10.17 0.49 2.41e-21 Hemoglobin concentration; LUSC cis rs2251381 0.523 rs2832306 chr21:30754468 C/T cg08807101 chr21:30365312 RNF160 -0.53 -8.17 -0.41 6.45e-15 Selective IgA deficiency; LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.53 6.47 0.33 3.47e-10 Renal function-related traits (BUN); LUSC trans rs7824557 0.767 rs1897950 chr8:11169551 C/A cg15556689 chr8:8085844 FLJ10661 0.56 8.54 0.42 4.93e-16 Retinal vascular caliber; LUSC cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg00071950 chr4:10020882 SLC2A9 0.65 11.05 0.52 2.17e-24 Bone mineral density; LUSC cis rs881375 0.715 rs10818482 chr9:123648085 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.43 -6.55 -0.34 2.17e-10 Rheumatoid arthritis; LUSC trans rs2898290 0.694 rs2248909 chr8:11392093 A/C cg08975724 chr8:8085496 FLJ10661 -0.5 -7.59 -0.38 3.19e-13 Systolic blood pressure; LUSC cis rs3096299 0.967 rs753852 chr16:89446419 G/A cg16743903 chr16:89593216 SPG7 -0.38 -5.85 -0.3 1.19e-8 Multiple myeloma (IgH translocation); LUSC cis rs2732480 0.523 rs34286639 chr12:48629044 C/T cg04545296 chr12:48745243 ZNF641 0.35 6.39 0.33 5.48e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs2230307 0.572 rs2810419 chr1:100643968 C/A cg24955406 chr1:100503596 HIAT1 -0.59 -6.45 -0.33 3.94e-10 Carotid intima media thickness; LUSC cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 19.14 0.72 1.19e-55 Chronic sinus infection; LUSC cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.6e-29 Motion sickness; LUSC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg13535736 chr9:111863775 C9orf5 -0.44 -6.99 -0.36 1.47e-11 Menarche (age at onset); LUSC cis rs7572644 0.509 rs13001060 chr2:28025061 T/C cg27432699 chr2:27873401 GPN1 0.56 7.3 0.37 2.09e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 15.35 0.64 1.33e-40 Platelet count; LUSC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg15839431 chr19:19639596 YJEFN3 -0.41 -5.68 -0.3 2.93e-8 Tonsillectomy; LUSC cis rs9486719 1.000 rs2499816 chr6:96878206 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg11764359 chr7:65958608 NA -0.58 -8.91 -0.44 3.25e-17 Aortic root size; LUSC cis rs593982 0.925 rs603509 chr11:65507605 C/T cg08755490 chr11:65554678 OVOL1 -1.36 -17.19 -0.69 6.56e-48 Atopic dermatitis; LUSC trans rs3942852 0.594 rs10769311 chr11:48094009 T/C cg15704280 chr7:45808275 SEPT13 -0.62 -8.09 -0.4 1.09e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg18240062 chr17:79603768 NPLOC4 0.58 9.87 0.48 2.58e-20 Eye color traits; LUSC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.3 0.49 8.56e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs908922 0.676 rs4845782 chr1:152492225 A/G cg20991723 chr1:152506922 NA 0.54 10.25 0.49 1.33e-21 Hair morphology; LUSC trans rs1005277 0.579 rs2474571 chr10:38384639 T/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.35 -0.46 1.35e-18 Extrinsic epigenetic age acceleration; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15399604 chr12:109535328 UNG -0.48 -7.17 -0.37 4.98e-12 Electrocardiographic conduction measures; LUSC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg26061582 chr7:22766209 IL6 0.49 7.02 0.36 1.25e-11 Lung cancer; LUSC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg17971929 chr21:40555470 PSMG1 -0.5 -7.46 -0.38 7.45e-13 Menarche (age at onset); LUSC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg20891283 chr12:69753455 YEATS4 0.63 9.56 0.46 2.7e-19 Response to diuretic therapy; LUSC cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg05535760 chr7:792225 HEATR2 0.76 8.9 0.44 3.54e-17 Cerebrospinal P-tau181p levels; LUSC cis rs483180 0.512 rs597308 chr1:120214953 G/A cg19096424 chr1:120255104 PHGDH 0.47 6.5 0.33 2.99e-10 Macular telangiectasia type 2; LUSC cis rs13401104 0.796 rs10929174 chr2:237116829 A/G cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC trans rs62103177 0.608 rs4799115 chr18:77736365 A/T cg14227996 chr4:17616232 MED28 -0.59 -6.39 -0.33 5.67e-10 Opioid sensitivity; LUSC cis rs78545713 0.649 rs114015443 chr6:26221979 A/G cg23601095 chr6:26197514 HIST1H3D 0.67 5.68 0.3 2.87e-8 Iron status biomarkers (total iron binding capacity); LUSC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg12257692 chr3:49977190 RBM6 -0.24 -6.42 -0.33 4.77e-10 Intelligence (multi-trait analysis); LUSC cis rs881375 0.967 rs1930780 chr9:123686219 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.35 5.82 0.3 1.39e-8 Rheumatoid arthritis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18746451 chr11:20385301 HTATIP2 -0.39 -5.96 -0.31 6.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.69 -0.34 9.46e-11 Monocyte percentage of white cells; LUSC cis rs877282 1.000 rs11253361 chr10:770387 T/C cg17470449 chr10:769945 NA 0.52 7.33 0.37 1.74e-12 Uric acid levels; LUSC cis rs62400317 0.859 rs4267941 chr6:45241302 A/C cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs854765 0.547 rs2955372 chr17:17970229 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.81 -14.68 -0.63 5.56e-38 Total body bone mineral density; LUSC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.85e-10 Bipolar disorder; LUSC cis rs7954584 0.616 rs10743185 chr12:122356435 G/A cg21171335 chr12:122356390 WDR66 0.54 7.77 0.39 9.57e-14 Mean corpuscular volume; LUSC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg07777115 chr5:623756 CEP72 -0.45 -5.77 -0.3 1.79e-8 Obesity-related traits; LUSC cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg11645453 chr3:52864694 ITIH4 0.47 10.67 0.5 4.58e-23 Schizophrenia; LUSC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg18196295 chr10:418757 DIP2C 0.46 7.67 0.39 1.89e-13 Psychosis in Alzheimer's disease; LUSC cis rs1358748 0.555 rs2475169 chr1:67534270 A/G cg02640540 chr1:67518911 SLC35D1 0.62 6.52 0.34 2.6e-10 Tuberculosis; LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.59 0.38 3.32e-13 Bipolar disorder; LUSC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg00745463 chr17:30367425 LRRC37B -0.71 -8.74 -0.43 1.14e-16 Hip circumference adjusted for BMI; LUSC cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 5.88 0.31 1.02e-8 Rheumatoid arthritis; LUSC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg06740227 chr12:86229804 RASSF9 0.44 7.11 0.36 7.01e-12 Major depressive disorder; LUSC cis rs11971779 0.680 rs1986447 chr7:139082080 G/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC trans rs13315871 0.929 rs7643185 chr3:58311158 A/C cg04606887 chr12:46121035 LOC400027 0.74 5.97 0.31 5.92e-9 Cholesterol, total; LUSC cis rs2014572 0.875 rs10405008 chr19:57753643 C/G cg24459738 chr19:57751996 ZNF805 0.5 7.33 0.37 1.72e-12 Hyperactive-impulsive symptoms; LUSC cis rs12421382 0.659 rs2028337 chr11:109380887 G/C cg11473876 chr11:109292803 C11orf87 0.39 6.32 0.33 8.41e-10 Schizophrenia; LUSC cis rs380904 0.519 rs1377663 chr8:144644787 T/A cg13399544 chr8:144649678 C8orf73 -0.43 -6.66 -0.34 1.15e-10 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg26839252 chr6:160211577 TCP1;MRPL18 0.47 6.29 0.33 1.01e-9 Age-related macular degeneration (geographic atrophy); LUSC cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg17420585 chr12:42539391 GXYLT1 -0.39 -7.67 -0.39 1.93e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10005894 chr3:186649165 ST6GAL1 0.39 6.17 0.32 2e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs193541 0.530 rs6595405 chr5:122084745 C/T cg19077854 chr5:122220652 SNX24 0.36 7.17 0.37 4.74e-12 Glucose homeostasis traits; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg24846343 chr22:24311635 DDTL 0.77 17.41 0.69 9.54e-49 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg05368731 chr17:41323189 NBR1 0.82 14.2 0.61 3.92e-36 Menopause (age at onset); LUSC cis rs9905704 0.671 rs2531733 chr17:56548811 A/G cg19466818 chr17:56409534 MIR142 0.37 6.69 0.34 9.44e-11 Testicular germ cell tumor; LUSC cis rs425277 1.000 rs74877653 chr1:2065949 C/T cg24578937 chr1:2090814 PRKCZ 0.61 13.84 0.6 9.41e-35 Height; LUSC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.36 -0.37 1.45e-12 Bipolar disorder; LUSC cis rs7527798 1.000 rs17186897 chr1:207839505 C/G cg09232269 chr1:207846808 CR1L -0.33 -6.28 -0.32 1.06e-9 Erythrocyte sedimentation rate; LUSC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.47 6.96 0.36 1.76e-11 Alzheimer's disease (late onset); LUSC trans rs12310956 0.532 rs1852226 chr12:33962940 G/A cg26384229 chr12:38710491 ALG10B 0.67 10.53 0.5 1.43e-22 Morning vs. evening chronotype; LUSC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg04450456 chr4:17643702 FAM184B 0.35 5.8 0.3 1.56e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs8077577 1.000 rs8077577 chr17:18064730 C/T cg16794390 chr17:18148240 FLII 0.44 6.28 0.33 1.03e-9 Obesity-related traits; LUSC cis rs4925114 0.568 rs11656775 chr17:17654319 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -6.96 -0.36 1.79e-11 Body mass index; LUSC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg08859206 chr1:53392774 SCP2 0.5 8.51 0.42 6.03e-16 Monocyte count; LUSC trans rs7980799 0.716 rs10161311 chr12:33623204 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.4 -0.33 5.18e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg00024416 chr22:24240387 NA -0.33 -5.71 -0.3 2.56e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7103648 0.630 rs7120548 chr11:47662932 A/G cg20307385 chr11:47447363 PSMC3 0.86 13.95 0.61 3.66e-35 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs7586879 0.789 rs67221599 chr2:25131948 T/C cg01884057 chr2:25150051 NA 0.41 8.47 0.42 8.07e-16 Body mass index; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg18099408 chr3:52552593 STAB1 -0.4 -6.96 -0.36 1.81e-11 Bipolar disorder; LUSC cis rs11828289 0.607 rs76811253 chr11:23222885 G/A cg20040320 chr11:23191996 NA -0.61 -6.3 -0.33 9.26e-10 Cancer; LUSC cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.36 0.46 1.18e-18 Personality dimensions; LUSC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.21 0.41 4.85e-15 Homoarginine levels; LUSC cis rs2455601 0.529 rs2653569 chr11:8986978 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -6.92 -0.35 2.34e-11 Schizophrenia; LUSC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg02187348 chr16:89574699 SPG7 0.58 9.58 0.46 2.31e-19 Multiple myeloma (IgH translocation); LUSC cis rs7223966 1.000 rs7220892 chr17:61908316 G/A cg00945038 chr17:61921165 SMARCD2 0.38 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg11584989 chr19:19387371 SF4 0.67 8.0 0.4 2.06e-14 Bipolar disorder; LUSC cis rs34779708 0.966 rs12773647 chr10:35440327 A/G cg03585969 chr10:35415529 CREM 0.59 8.75 0.43 1.07e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1044826 0.667 rs2083336 chr3:139201272 T/G cg15131784 chr3:139108705 COPB2 0.4 6.38 0.33 5.94e-10 Obesity-related traits; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg07869135 chr8:123794843 ZHX2 0.45 6.36 0.33 6.56e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.95 13.36 0.59 6.28e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs9747201 0.962 rs35051180 chr17:80135046 G/A cg07393940 chr7:158741817 NA -0.54 -8.75 -0.43 1.06e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7980687 0.596 rs1727319 chr12:123701353 T/C cg00376283 chr12:123451042 ABCB9 0.68 9.69 0.47 9.85e-20 Height;Educational attainment;Head circumference (infant); LUSC cis rs3091242 0.900 rs1811832 chr1:25753565 G/A cg27572855 chr1:25598939 RHD 0.47 8.3 0.41 2.53e-15 Erythrocyte sedimentation rate; LUSC cis rs8141529 0.732 rs5762815 chr22:29205076 A/G cg02153584 chr22:29168773 CCDC117 0.66 10.7 0.51 3.52e-23 Lymphocyte counts; LUSC trans rs28735056 0.591 rs2277724 chr18:77694294 C/A cg05926928 chr17:57297772 GDPD1 -0.47 -6.73 -0.35 7.39e-11 Schizophrenia; LUSC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg18252515 chr7:66147081 NA -1.19 -12.84 -0.57 5.85e-31 Diabetic kidney disease; LUSC cis rs11039100 0.607 rs11038961 chr11:5780983 A/G cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9653442 0.564 rs2164711 chr2:100775422 G/T cg22139774 chr2:100720529 AFF3 -0.42 -7.2 -0.37 3.92e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg22029157 chr1:209979665 IRF6 0.72 10.69 0.5 3.82e-23 Cleft lip with or without cleft palate; LUSC cis rs5769765 0.908 rs138864 chr22:50204712 G/A cg02269571 chr22:50332266 NA -0.54 -8.11 -0.41 1e-14 Schizophrenia; LUSC cis rs12908161 1.000 rs11637142 chr15:85295927 A/G cg12863693 chr15:85201151 NMB 0.41 8.48 0.42 7.34e-16 Schizophrenia; LUSC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03934478 chr11:495069 RNH1 0.82 9.84 0.47 3.08e-20 Body mass index; LUSC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg01475377 chr6:109611718 NA -0.43 -7.78 -0.39 8.93e-14 Reticulocyte fraction of red cells; LUSC cis rs796364 0.616 rs2689762 chr2:200687204 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 5.98 0.31 5.78e-9 Schizophrenia; LUSC cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg23788917 chr6:8435910 SLC35B3 0.5 7.37 0.37 1.32e-12 Motion sickness; LUSC trans rs877282 0.945 rs877280 chr10:771599 C/T cg13042288 chr15:90349979 ANPEP -0.49 -6.86 -0.35 3.39e-11 Uric acid levels; LUSC cis rs225245 0.817 rs225290 chr17:33927904 C/G cg05299278 chr17:33885742 SLFN14 0.31 6.9 0.35 2.59e-11 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg04025307 chr7:1156635 C7orf50 0.44 6.09 0.32 3.17e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs739496 0.542 rs10219736 chr12:111788402 C/T cg10833066 chr12:111807467 FAM109A 0.6 11.76 0.54 6.2e-27 Platelet count; LUSC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg17366294 chr4:99064904 C4orf37 0.61 10.91 0.51 6.76e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs778371 0.723 rs1973675 chr2:233636450 C/T cg08000102 chr2:233561755 GIGYF2 -0.8 -14.03 -0.61 1.85e-35 Schizophrenia; LUSC cis rs273573 0.925 rs163883 chr11:30947248 A/G cg06552810 chr11:31128660 NA 0.33 5.73 0.3 2.26e-8 Total body bone mineral density; LUSC cis rs7590720 1.000 rs7559031 chr2:216902583 A/G cg12620499 chr2:216877984 MREG 0.93 14.09 0.61 1.09e-35 Alcohol dependence; LUSC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg14552801 chr7:65878734 NA 0.38 5.93 0.31 7.55e-9 Aortic root size; LUSC cis rs1124376 1.000 rs61457790 chr3:20136186 G/A cg05072819 chr3:20081367 KAT2B 0.66 7.43 0.38 9.24e-13 Bipolar disorder and schizophrenia; LUSC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg00166722 chr3:10149974 C3orf24 -0.6 -7.92 -0.4 3.51e-14 Alzheimer's disease; LUSC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg08564027 chr20:61660810 NA 0.93 18.01 0.7 3.73e-51 Prostate cancer (SNP x SNP interaction); LUSC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg00750074 chr16:89608354 SPG7 -0.54 -9.72 -0.47 7.68e-20 Multiple myeloma (IgH translocation); LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.34 0.59 7.64e-33 Platelet count; LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg05368731 chr17:41323189 NBR1 0.93 15.66 0.65 7.69e-42 Menopause (age at onset); LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg27284194 chr4:1044797 NA 0.35 5.9 0.31 8.97e-9 Longevity; LUSC cis rs12618769 0.652 rs72821965 chr2:99188783 T/C cg10123293 chr2:99228465 UNC50 0.46 7.37 0.37 1.38e-12 Bipolar disorder; LUSC cis rs12368653 0.641 rs12826708 chr12:58058373 G/A cg18357645 chr12:58087776 OS9 0.42 6.25 0.32 1.25e-9 Multiple sclerosis; LUSC cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg27170947 chr2:26402098 FAM59B 0.73 10.81 0.51 1.45e-23 Gut microbiome composition (summer); LUSC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg18681998 chr4:17616180 MED28 0.85 16.09 0.66 1.53e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs9886428 1.000 rs1427025 chr8:14118890 T/C cg11959399 chr20:741723 C20orf54 -0.4 -6.28 -0.32 1.05e-9 IgG glycosylation; LUSC cis rs12421382 0.659 rs1837396 chr11:109389257 G/A cg16359550 chr11:109292809 C11orf87 0.34 5.99 0.31 5.43e-9 Schizophrenia; LUSC cis rs55665837 1.000 rs11023227 chr11:14459087 T/C cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 6.93e-13 Vitamin D levels; LUSC cis rs1538970 0.961 rs7543428 chr1:45839643 A/G cg06784218 chr1:46089804 CCDC17 0.33 5.99 0.31 5.45e-9 Platelet count; LUSC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg02018176 chr4:1364513 KIAA1530 0.5 8.8 0.43 7.3e-17 Obesity-related traits; LUSC trans rs11992162 0.591 rs35657308 chr8:11804402 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.67 -0.34 1.07e-10 Monocyte count; LUSC cis rs7524258 0.903 rs6577424 chr1:7292417 C/T cg07173049 chr1:7289937 CAMTA1 -0.35 -7.24 -0.37 3.07e-12 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7681440 0.647 rs1442133 chr4:90819195 C/T cg15133208 chr4:90757351 SNCA -0.35 -5.97 -0.31 5.96e-9 Dementia with Lewy bodies; LUSC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg22800045 chr5:56110881 MAP3K1 0.4 5.66 0.3 3.29e-8 Breast cancer;Breast cancer (early onset); LUSC cis rs11098499 0.754 rs10518300 chr4:120249499 G/T cg24375607 chr4:120327624 NA -0.75 -11.61 -0.54 2.15e-26 Corneal astigmatism; LUSC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs738321 0.757 rs3788536 chr22:38534209 C/T cg25457927 chr22:38595422 NA -0.37 -7.07 -0.36 9.26e-12 Breast cancer; LUSC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg07661805 chr8:143867942 LY6D -0.25 -5.78 -0.3 1.73e-8 Urinary tract infection frequency; LUSC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg04369109 chr6:150039330 LATS1 -0.52 -7.46 -0.38 7.37e-13 Lung cancer; LUSC cis rs4144743 1.000 rs55827077 chr17:45331083 G/C cg18085866 chr17:45331354 ITGB3 -0.75 -7.81 -0.39 7.52e-14 Body mass index; LUSC cis rs9611519 0.894 rs4821998 chr22:41468273 C/G cg13813247 chr22:41461852 NA -0.37 -6.59 -0.34 1.67e-10 Neuroticism; LUSC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg17173187 chr15:85201210 NMB -0.3 -5.97 -0.31 5.96e-9 P wave terminal force; LUSC cis rs10465746 0.653 rs11163877 chr1:84441848 T/A cg10977910 chr1:84465055 TTLL7 0.44 6.41 0.33 4.83e-10 Obesity-related traits; LUSC cis rs4466137 0.953 rs1585153 chr5:83000385 A/T cg16102102 chr5:83017553 HAPLN1 -0.93 -14.07 -0.61 1.2e-35 Prostate cancer; LUSC cis rs360798 0.512 rs12989754 chr2:63020970 A/G cg17519650 chr2:63277830 OTX1 -0.52 -7.37 -0.37 1.37e-12 Coronary artery disease; LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC trans rs637571 0.522 rs1786175 chr11:65754808 G/A cg17712092 chr4:129076599 LARP1B 0.74 11.16 0.52 8.74e-25 Eosinophil percentage of white cells; LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg23788917 chr6:8435910 SLC35B3 0.5 7.44 0.38 8.79e-13 Motion sickness; LUSC cis rs9300255 0.602 rs2851435 chr12:123712416 G/A cg00376283 chr12:123451042 ABCB9 0.66 7.57 0.38 3.57e-13 Neutrophil percentage of white cells; LUSC trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21659725 chr3:3221576 CRBN -0.58 -8.15 -0.41 7.26e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs12682352 0.602 rs1473029 chr8:8668917 A/C cg06636001 chr8:8085503 FLJ10661 0.57 8.45 0.42 8.8e-16 Neuroticism; LUSC cis rs4631830 0.863 rs10826127 chr10:51530757 G/A cg10326726 chr10:51549505 MSMB -0.38 -6.53 -0.34 2.51e-10 Prostate-specific antigen levels; LUSC cis rs7953508 0.711 rs10492321 chr12:93980088 T/A cg18151635 chr12:93972918 NA -0.56 -7.74 -0.39 1.17e-13 Pubertal anthropometrics; LUSC cis rs10791097 0.694 rs7125622 chr11:130743388 T/C cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs4820539 1.000 rs2267003 chr22:23457098 A/G cg21100191 chr22:23484243 RTDR1 0.86 14.34 0.62 1.11e-36 Bone mineral density; LUSC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg22800045 chr5:56110881 MAP3K1 -0.43 -5.93 -0.31 7.39e-9 Coronary artery disease; LUSC cis rs7759001 0.817 rs6934985 chr6:27354943 T/G cg18711553 chr6:27366782 ZNF391 0.39 5.74 0.3 2.1e-8 Glomerular filtration rate (creatinine); LUSC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 11.96 0.55 1.14e-27 Personality dimensions; LUSC cis rs1113500 0.614 rs6677839 chr1:108599341 G/T cg06207961 chr1:108661230 NA -0.36 -5.94 -0.31 7.02e-9 Growth-regulated protein alpha levels; LUSC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg21248554 chr2:27665150 KRTCAP3 -0.28 -5.75 -0.3 2.02e-8 Total body bone mineral density; LUSC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg08470875 chr2:26401718 FAM59B -0.66 -8.63 -0.43 2.55e-16 Gut microbiome composition (summer); LUSC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg22166914 chr1:53195759 ZYG11B -0.57 -9.26 -0.45 2.57e-18 Monocyte count; LUSC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg15556689 chr8:8085844 FLJ10661 -0.57 -8.54 -0.42 4.84e-16 Joint mobility (Beighton score); LUSC cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg03264133 chr6:25882463 NA -0.5 -9.15 -0.45 5.74e-18 Blood metabolite levels; LUSC trans rs2261181 0.803 rs2583937 chr12:66235464 C/T cg19918230 chr2:219745647 WNT10A 0.55 6.09 0.32 3.02e-9 Type 2 diabetes; LUSC cis rs317689 0.718 rs645026 chr12:69757931 G/A cg20891283 chr12:69753455 YEATS4 0.57 7.63 0.39 2.42e-13 Response to diuretic therapy; LUSC cis rs12476592 0.602 rs262503 chr2:63860437 G/A cg10828910 chr2:63850056 LOC388955 0.48 5.7 0.3 2.69e-8 Childhood ear infection; LUSC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg06634786 chr22:41940651 POLR3H 0.52 6.16 0.32 2.11e-9 Vitiligo; LUSC cis rs7586879 0.616 rs916485 chr2:25082273 T/C cg15423357 chr2:25149977 NA 0.37 7.38 0.37 1.3e-12 Body mass index; LUSC cis rs6582630 0.598 rs12823134 chr12:38514347 T/A cg26384229 chr12:38710491 ALG10B -0.55 -8.27 -0.41 3.33e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs79911532 0.515 rs76180651 chr7:75704350 T/G cg03592824 chr7:75666768 STYXL1 0.67 6.42 0.33 4.79e-10 Mononucleosis; LUSC cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg08085267 chr17:45401833 C17orf57 0.45 6.62 0.34 1.44e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6500395 0.889 rs2080507 chr16:48688634 T/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg08999081 chr20:33150536 PIGU 0.52 10.43 0.5 3.08e-22 Glomerular filtration rate (creatinine); LUSC cis rs240764 0.584 rs11155653 chr6:101217123 G/A cg09795085 chr6:101329169 ASCC3 -0.41 -6.04 -0.31 4.05e-9 Neuroticism; LUSC cis rs9633740 1.000 rs1870138 chr10:82269611 A/G cg01528321 chr10:82214614 TSPAN14 1.08 12.05 0.55 5.18e-28 Post bronchodilator FEV1; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg00166722 chr3:10149974 C3orf24 0.59 7.87 0.4 4.84e-14 Alzheimer's disease; LUSC cis rs4786125 0.636 rs7187960 chr16:6919183 G/T cg03623568 chr16:6915990 A2BP1 -0.5 -8.39 -0.42 1.38e-15 Heart rate variability traits (SDNN); LUSC cis rs11585357 0.895 rs877552 chr1:17631236 C/T cg08277548 chr1:17600880 PADI3 -0.59 -6.26 -0.32 1.16e-9 Hair shape; LUSC cis rs12541635 0.966 rs2029881 chr8:107002226 A/G cg10147462 chr8:107024639 NA 0.55 9.96 0.48 1.27e-20 Age of smoking initiation; LUSC cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg15691649 chr6:25882328 NA 0.51 7.52 0.38 5.19e-13 Blood metabolite levels; LUSC cis rs12477438 0.765 rs6722164 chr2:99561527 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.49 -0.5 1.86e-22 Chronic sinus infection; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07747515 chr11:61659326 FADS3 -0.41 -6.08 -0.32 3.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs34779708 0.966 rs113170867 chr10:35450147 C/T cg03585969 chr10:35415529 CREM 0.61 8.87 0.44 4.36e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg26818010 chr10:134567672 INPP5A 0.87 12.06 0.55 4.93e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10927875 0.632 rs10927863 chr1:16165247 C/A cg21385522 chr1:16154831 NA -1.02 -20.5 -0.75 4.92e-61 Dilated cardiomyopathy; LUSC cis rs7131987 0.834 rs11050167 chr12:29426387 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.66 -0.34 1.14e-10 QT interval; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg04234412 chr22:24373322 LOC391322 -0.82 -13.22 -0.59 2.27e-32 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.51 0.62 2.44e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg05283184 chr6:79620031 NA -0.57 -12.18 -0.55 1.73e-28 Intelligence (multi-trait analysis); LUSC cis rs3617 0.573 rs12638968 chr3:52919447 T/A cg18404041 chr3:52824283 ITIH1 0.43 7.45 0.38 7.93e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9398803 0.678 rs1155938 chr6:126866472 C/A cg19875578 chr6:126661172 C6orf173 0.4 5.71 0.3 2.5e-8 Male-pattern baldness; LUSC cis rs950169 0.614 rs765524 chr15:84681782 G/T cg11189052 chr15:85197271 WDR73 0.53 5.99 0.31 5.36e-9 Schizophrenia; LUSC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.97 0.31 6.17e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg20503657 chr10:835505 NA 0.94 13.57 0.6 1.03e-33 Eosinophil percentage of granulocytes; LUSC cis rs11048434 0.761 rs11494570 chr12:9127147 T/C cg13575925 chr12:9217583 LOC144571 0.34 6.17 0.32 2.02e-9 Sjögren's syndrome; LUSC trans rs11098499 0.954 rs13151285 chr4:120314741 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg06808227 chr14:105710500 BRF1 -0.65 -9.96 -0.48 1.23e-20 Mean platelet volume;Platelet distribution width; LUSC cis rs1775715 1.000 rs1775715 chr10:32309005 A/G cg26784012 chr10:32216390 ARHGAP12 -0.38 -6.15 -0.32 2.27e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2075165 0.838 rs12072638 chr1:156267480 T/G cg20302342 chr1:156215951 PAQR6 0.33 6.29 0.33 9.95e-10 Tonsillectomy; LUSC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg00033643 chr7:134001901 SLC35B4 0.46 7.18 0.37 4.61e-12 Mean platelet volume; LUSC cis rs500891 0.574 rs12208468 chr6:84134464 C/T cg08257003 chr6:84140564 ME1 0.35 7.74 0.39 1.18e-13 Platelet-derived growth factor BB levels; LUSC cis rs8135665 0.600 rs6519097 chr22:38451465 C/T cg13116946 chr22:38479732 SLC16A8 0.41 6.17 0.32 1.95e-9 Advanced age-related macular degeneration;Age-related macular degeneration; LUSC cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg13319975 chr6:146136371 FBXO30 0.5 7.48 0.38 6.84e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -7.71 -0.39 1.46e-13 Lymphocyte counts; LUSC cis rs7681440 0.583 rs2583965 chr4:90740103 G/T cg06632027 chr4:90757378 SNCA -0.36 -5.69 -0.3 2.71e-8 Dementia with Lewy bodies; LUSC cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg05707623 chr12:122985044 ZCCHC8 -0.66 -8.33 -0.41 2.14e-15 Body mass index; LUSC cis rs1550582 0.662 rs6981748 chr8:135501309 A/C cg17885191 chr8:135476712 NA -0.89 -14.21 -0.61 3.58e-36 Educational attainment; LUSC cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg09904177 chr6:26538194 HMGN4 0.49 7.77 0.39 9.71e-14 Schizophrenia; LUSC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.44 -0.33 4.16e-10 Total body bone mineral density; LUSC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg13531842 chr10:38383804 ZNF37A -0.44 -6.85 -0.35 3.55e-11 Extrinsic epigenetic age acceleration; LUSC cis rs9527 0.615 rs10883800 chr10:104671212 A/C cg04362960 chr10:104952993 NT5C2 0.59 9.23 0.45 3.21e-18 Arsenic metabolism; LUSC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC trans rs11039798 1.000 rs7125559 chr11:48984207 C/G cg03929089 chr4:120376271 NA 0.71 6.79 0.35 5.04e-11 Axial length; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14728310 chr19:9879317 ZNF846 0.45 7.16 0.36 5.28e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg13010199 chr12:38710504 ALG10B 0.49 7.48 0.38 6.62e-13 Morning vs. evening chronotype; LUSC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg10360323 chr17:41437877 NA 0.41 5.92 0.31 7.78e-9 Menopause (age at onset); LUSC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg11645453 chr3:52864694 ITIH4 0.36 8.63 0.43 2.5e-16 Bipolar disorder; LUSC trans rs1486139 1.000 rs723287 chr7:46283897 T/G cg17534202 chr9:96721102 NA -0.37 -6.56 -0.34 2.01e-10 Select biomarker traits; LUSC cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg11645453 chr3:52864694 ITIH4 -0.33 -7.37 -0.37 1.32e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC trans rs61931739 0.500 rs11053207 chr12:34459827 A/G cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.37e-18 Morning vs. evening chronotype; LUSC cis rs559928 0.606 rs56311067 chr11:63931607 C/T cg24687543 chr11:63912206 MACROD1 0.47 5.82 0.3 1.4e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg13535736 chr9:111863775 C9orf5 -0.36 -6.0 -0.31 5.15e-9 Menarche (age at onset); LUSC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg20406979 chr6:167373233 NA 0.25 5.94 0.31 7.16e-9 Crohn's disease; LUSC cis rs4363385 0.510 rs6689066 chr1:153045154 T/C cg00922841 chr1:152955080 SPRR1A -0.36 -6.07 -0.32 3.4e-9 Inflammatory skin disease; LUSC trans rs6502050 0.835 rs8067875 chr17:80092778 C/T cg07393940 chr7:158741817 NA 0.38 6.79 0.35 5.07e-11 Life satisfaction; LUSC cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg02187348 chr16:89574699 SPG7 -0.47 -7.02 -0.36 1.24e-11 Multiple myeloma (IgH translocation); LUSC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.45 -6.89 -0.35 2.75e-11 Bipolar disorder; LUSC cis rs9910055 0.593 rs2905983 chr17:42212429 T/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.47 -8.73 -0.43 1.28e-16 Total body bone mineral density; LUSC cis rs7666738 0.515 rs10015315 chr4:98700137 A/G cg17366294 chr4:99064904 C4orf37 0.54 8.44 0.42 9.91e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.14e-9 Total body bone mineral density; LUSC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg00750074 chr16:89608354 SPG7 0.43 7.04 0.36 1.11e-11 Multiple myeloma (IgH translocation); LUSC cis rs7615952 0.673 rs9821905 chr3:125620850 A/G cg05084668 chr3:125655381 ALG1L 0.82 12.04 0.55 5.48e-28 Blood pressure (smoking interaction); LUSC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg13390004 chr1:15929781 NA -0.4 -6.77 -0.35 5.79e-11 Systolic blood pressure; LUSC cis rs7904368 1.000 rs7904368 chr10:16858587 C/T cg23933602 chr10:16859644 RSU1 0.62 8.22 0.41 4.6e-15 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.97 0.36 1.74e-11 Intelligence (multi-trait analysis); LUSC cis rs4843747 0.671 rs28671027 chr16:88116323 G/A cg09044154 chr16:88155775 NA -0.55 -7.35 -0.37 1.54e-12 Menopause (age at onset); LUSC cis rs11622475 1.000 rs8021692 chr14:104428576 C/G cg12183467 chr14:104352244 NA -0.43 -7.32 -0.37 1.81e-12 Bipolar disorder; LUSC cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg13319975 chr6:146136371 FBXO30 -0.51 -7.79 -0.39 8.33e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg03806693 chr22:41940476 POLR3H 1.01 14.56 0.62 1.55e-37 Vitiligo; LUSC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg27211696 chr2:191398769 TMEM194B 0.63 12.17 0.55 1.83e-28 Pulse pressure; LUSC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg09021430 chr5:549028 NA -0.55 -7.45 -0.38 8.21e-13 Obesity-related traits; LUSC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg12463550 chr7:65579703 CRCP 0.42 6.17 0.32 1.98e-9 Aortic root size; LUSC cis rs7177699 0.557 rs10083697 chr15:79124039 G/A cg15571903 chr15:79123663 NA -0.36 -6.58 -0.34 1.8e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9952991 1.000 rs9952991 chr18:12780464 G/A cg23598886 chr18:12777645 NA 0.65 6.47 0.33 3.49e-10 Inflammatory skin disease; LUSC cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg03676636 chr4:99064102 C4orf37 0.36 8.04 0.4 1.54e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg14092988 chr3:52407081 DNAH1 0.3 5.96 0.31 6.38e-9 Bipolar disorder; LUSC cis rs2295359 1.000 rs12043240 chr1:67624304 C/T cg03340356 chr1:67600835 NA 0.4 6.48 0.33 3.37e-10 Psoriasis; LUSC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg02772935 chr3:125709198 NA -0.48 -5.84 -0.3 1.23e-8 Blood pressure (smoking interaction); LUSC trans rs9929218 0.906 rs34565494 chr16:68741769 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -12.78 -0.57 9.91e-31 Colorectal cancer; LUSC trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg15704280 chr7:45808275 SEPT13 -0.83 -11.57 -0.53 2.98e-26 Coronary artery disease; LUSC cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg07061783 chr6:25882402 NA -0.38 -5.94 -0.31 7.15e-9 Blood metabolite levels; LUSC trans rs7824557 0.628 rs7008205 chr8:11197323 T/G cg08975724 chr8:8085496 FLJ10661 0.43 6.2 0.32 1.62e-9 Retinal vascular caliber; LUSC cis rs4845459 0.967 rs477392 chr1:152555176 C/G cg08895932 chr1:152778580 LCE1C -0.37 -6.34 -0.33 7.64e-10 Psoriasis; LUSC cis rs2637266 0.756 rs846631 chr10:78536928 T/G cg18941641 chr10:78392320 NA 0.39 7.05 0.36 1.05e-11 Pulmonary function; LUSC cis rs8028313 0.630 rs3784700 chr15:68017752 A/G cg08079166 chr15:68083412 MAP2K5 0.38 6.46 0.33 3.8e-10 Obesity; LUSC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg16145915 chr7:1198662 ZFAND2A -0.67 -13.21 -0.59 2.45e-32 Longevity;Endometriosis; LUSC cis rs6964587 0.967 rs7786031 chr7:91649001 T/G cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.6e-8 Breast cancer; LUSC cis rs9308433 0.643 rs4655330 chr1:214466068 A/G cg06198575 chr1:214491504 SMYD2 -0.44 -6.75 -0.35 6.64e-11 IgG glycosylation; LUSC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg11214544 chr1:2391121 NA -0.6 -9.44 -0.46 6.82e-19 Non-obstructive azoospermia; LUSC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.96 -0.31 6.37e-9 Platelet count; LUSC cis rs12908161 1.000 rs34900908 chr15:85257599 G/A cg17173187 chr15:85201210 NMB 0.51 9.69 0.47 9.71e-20 Schizophrenia; LUSC cis rs6696846 0.936 rs6662930 chr1:205041465 T/C cg03948781 chr1:205179583 DSTYK 0.31 5.78 0.3 1.67e-8 Red blood cell count; LUSC cis rs765787 0.530 rs12906537 chr15:45520061 T/C cg25801113 chr15:45476975 SHF -0.36 -7.07 -0.36 8.83e-12 Uric acid levels; LUSC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs1908814 0.516 rs10113062 chr8:11793249 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.02 0.31 4.61e-9 Neuroticism; LUSC cis rs8056893 0.714 rs9931501 chr16:68402686 A/G cg02226672 chr16:68398533 SMPD3 0.32 5.69 0.3 2.85e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC cis rs7903847 0.620 rs10882903 chr10:99115584 A/T cg20016023 chr10:99160130 RRP12 -0.33 -8.0 -0.4 2.03e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs1950626 0.623 rs34448411 chr14:101429287 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.45 0.38 7.95e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg14983838 chr19:29218262 NA 0.48 5.92 0.31 8e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs2898681 0.567 rs77657787 chr4:53729981 G/A cg21521518 chr4:53727714 RASL11B 0.49 6.05 0.31 3.97e-9 Optic nerve measurement (cup area); LUSC trans rs867371 0.502 rs1846908 chr15:82522526 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.4 -0.33 5.18e-10 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg19257562 chr1:2043853 PRKCZ 0.31 6.16 0.32 2.04e-9 Height; LUSC trans rs11098499 0.863 rs1155576 chr4:120450159 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.66 0.34 1.14e-10 Corneal astigmatism; LUSC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg17252645 chr8:143867129 LY6D 0.38 6.7 0.34 8.92e-11 Urinary tract infection frequency; LUSC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg12310025 chr6:25882481 NA -0.48 -8.31 -0.41 2.45e-15 Intelligence (multi-trait analysis); LUSC cis rs10779751 0.734 rs910660 chr1:11130643 C/T cg04508216 chr1:11107452 MASP2 -0.32 -5.87 -0.31 1.05e-8 Body mass index; LUSC cis rs4595586 0.505 rs12823590 chr12:39399750 A/T cg26384229 chr12:38710491 ALG10B 0.49 6.88 0.35 2.88e-11 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg24829409 chr8:58192753 C8orf71 -0.54 -5.92 -0.31 8.21e-9 Developmental language disorder (linguistic errors); LUSC trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg08975724 chr8:8085496 FLJ10661 -0.52 -8.05 -0.4 1.46e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7973719 0.769 rs61917956 chr12:7348659 T/C cg07052231 chr12:7363540 PEX5 0.53 9.27 0.45 2.41e-18 IgG glycosylation; LUSC cis rs10504073 0.584 rs4873306 chr8:49950369 T/C cg00325661 chr8:49890786 NA 0.69 11.04 0.52 2.2e-24 Blood metabolite ratios; LUSC cis rs62283056 0.512 rs10028875 chr4:6283460 C/T cg25554036 chr4:6271136 WFS1 0.51 9.11 0.45 7.56e-18 Cisplatin-induced ototoxicity; LUSC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.47 -7.16 -0.36 5.16e-12 Colorectal cancer; LUSC trans rs208520 0.690 rs10455595 chr6:66738034 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 16.82 0.68 2.11e-46 Exhaled nitric oxide output; LUSC cis rs1322512 0.917 rs2758811 chr6:152964405 G/A cg27316956 chr6:152958899 SYNE1 -0.37 -6.39 -0.33 5.51e-10 Tonometry; LUSC trans rs11696501 0.688 rs6073848 chr20:44298550 G/A cg03272292 chr12:48577362 C12orf68 0.5 6.07 0.32 3.47e-9 Brain structure; LUSC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.42 0.53 1.03e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs11098499 0.739 rs951570 chr4:120150467 T/C cg24375607 chr4:120327624 NA -0.68 -10.75 -0.51 2.31e-23 Corneal astigmatism; LUSC cis rs6479527 0.625 rs1933667 chr9:96744109 G/C cg07076509 chr9:96720819 NA 0.31 6.18 0.32 1.91e-9 Esophageal adenocarcinoma; LUSC cis rs6964587 1.000 rs6979085 chr7:91673623 C/T cg22709100 chr7:91322751 NA 0.39 5.79 0.3 1.64e-8 Breast cancer; LUSC cis rs727505 1.000 rs10230610 chr7:124425398 A/C cg14311320 chr7:124405732 GPR37 -0.33 -5.77 -0.3 1.79e-8 Lewy body disease; LUSC cis rs6733011 0.500 rs11123754 chr2:99433782 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.73 -0.3 2.27e-8 Bipolar disorder; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 14.07 0.61 1.24e-35 Platelet count; LUSC cis rs11105298 0.891 rs3741898 chr12:89933763 G/C cg00757033 chr12:89920650 WDR51B 0.61 10.77 0.51 2.12e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg18681998 chr4:17616180 MED28 0.76 13.24 0.59 1.83e-32 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs17685 0.753 rs10245584 chr7:75745866 C/T cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.78e-57 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg03929089 chr4:120376271 NA 0.81 11.34 0.53 2e-25 Coronary artery disease; LUSC cis rs9581857 0.512 rs9581874 chr13:28086956 A/G cg22138327 chr13:27999177 GTF3A 0.69 7.16 0.36 5.12e-12 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs16854884 0.770 rs7653331 chr3:143810909 G/A cg06585982 chr3:143692056 C3orf58 0.45 6.7 0.34 8.88e-11 Economic and political preferences (feminism/equality); LUSC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg20203395 chr5:56204925 C5orf35 -0.54 -7.65 -0.39 2.19e-13 Coronary artery disease; LUSC cis rs7949030 1.000 rs3018561 chr11:62392229 C/A cg13298116 chr11:62369859 EML3;MTA2 -0.51 -8.58 -0.42 3.62e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16439512 chr15:57598924 LOC283663 0.38 5.96 0.31 6.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg03709012 chr19:19516395 GATAD2A 0.83 13.78 0.6 1.6e-34 Tonsillectomy; LUSC cis rs477692 0.905 rs693402 chr10:131422882 G/A cg26102564 chr10:131424627 MGMT 0.37 5.79 0.3 1.59e-8 Response to temozolomide; LUSC cis rs59698941 0.943 rs57550938 chr5:132248104 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs7760949 0.963 rs7761500 chr6:13917140 G/A cg27413430 chr6:13925136 RNF182 0.55 8.1 0.41 1.04e-14 Mean corpuscular hemoglobin concentration; LUSC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.42 5.67 0.3 3.14e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18211447 chr14:102771717 RAGE 0.43 6.32 0.33 8.4e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg08773314 chr2:239334832 ASB1 0.42 9.13 0.45 6.68e-18 Multiple system atrophy; LUSC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg25427524 chr10:38739819 LOC399744 0.63 11.26 0.52 3.76e-25 Extrinsic epigenetic age acceleration; LUSC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg05368731 chr17:41323189 NBR1 0.84 14.11 0.61 8.91e-36 Menopause (age at onset); LUSC cis rs2294693 0.947 rs9349176 chr6:40989525 C/T cg14769373 chr6:40998127 UNC5CL -0.56 -8.18 -0.41 5.95e-15 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs1670533 1.000 rs2290411 chr4:1051077 T/C cg02018176 chr4:1364513 KIAA1530 0.46 6.44 0.33 4.26e-10 Recombination rate (females); LUSC cis rs7119 0.636 rs34020536 chr15:77819586 G/A cg27398640 chr15:77910606 LINGO1 -0.31 -6.39 -0.33 5.48e-10 Type 2 diabetes; LUSC cis rs4073416 0.502 rs4359350 chr14:65863748 T/C cg03016385 chr14:66212404 NA -0.37 -5.98 -0.31 5.67e-9 N-glycan levels; LUSC cis rs7523273 0.606 rs1830764 chr1:207917052 G/A cg22525895 chr1:207977042 MIR29B2 0.4 6.62 0.34 1.42e-10 Schizophrenia; LUSC cis rs2797160 1.000 rs1739371 chr6:126011291 G/A cg05901451 chr6:126070800 HEY2 0.57 8.45 0.42 9.24e-16 Endometrial cancer; LUSC cis rs208520 0.754 rs851593 chr6:66875783 C/T cg07460842 chr6:66804631 NA 1.11 17.18 0.69 7.27e-48 Exhaled nitric oxide output; LUSC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg20295408 chr7:1910781 MAD1L1 -0.46 -6.35 -0.33 7.01e-10 Schizophrenia; LUSC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg19592336 chr6:28129416 ZNF389 0.46 6.38 0.33 5.9e-10 Parkinson's disease; LUSC trans rs9650657 0.571 rs4240673 chr8:10787612 T/C cg06636001 chr8:8085503 FLJ10661 -0.54 -7.88 -0.4 4.58e-14 Neuroticism; LUSC cis rs10740039 0.804 rs894383 chr10:62443117 A/G cg18175470 chr10:62150864 ANK3 -0.43 -6.54 -0.34 2.29e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg20785333 chr3:119013442 CDGAP -0.52 -6.41 -0.33 5.06e-10 Neuroticism; LUSC cis rs1692580 0.870 rs263532 chr1:2164116 T/C cg24578937 chr1:2090814 PRKCZ 0.39 8.2 0.41 5.23e-15 Coronary artery disease; LUSC trans rs57221529 0.766 rs72703065 chr5:588123 C/A cg25482853 chr8:67687455 SGK3 1.18 16.97 0.68 5.1e-47 Lung disease severity in cystic fibrosis; LUSC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg20887711 chr4:1340912 KIAA1530 0.47 7.15 0.36 5.57e-12 Obesity-related traits; LUSC cis rs2439831 0.541 rs12440854 chr15:43610672 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.92 9.77 0.47 5.46e-20 Lung cancer in ever smokers; LUSC cis rs9398803 0.865 rs9398808 chr6:126758791 G/T cg19875578 chr6:126661172 C6orf173 0.41 6.09 0.32 3.18e-9 Male-pattern baldness; LUSC cis rs28655083 0.828 rs7404322 chr16:77130003 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.53 8.07 0.4 1.31e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs897080 0.515 rs1085444 chr2:44624155 A/G cg00619915 chr2:44497795 NA -0.41 -5.82 -0.3 1.35e-8 Height; LUSC cis rs7819412 0.623 rs7833435 chr8:10801137 A/G cg21775007 chr8:11205619 TDH -0.48 -6.8 -0.35 4.79e-11 Triglycerides; LUSC cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg18904891 chr8:8559673 CLDN23 0.57 7.98 0.4 2.33e-14 Obesity-related traits; LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.3 0.37 2.16e-12 Platelet count; LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg07507251 chr3:52567010 NT5DC2 0.33 6.54 0.34 2.28e-10 Bipolar disorder; LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg11062466 chr8:58055876 NA 0.69 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7586879 0.765 rs6545758 chr2:25074874 C/T cg04586622 chr2:25135609 ADCY3 -0.31 -5.92 -0.31 8.2e-9 Body mass index; LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg27588902 chr6:42928151 GNMT -0.29 -6.44 -0.33 4.12e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg00701064 chr4:6280414 WFS1 0.5 11.5 0.53 5.23e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7582180 0.676 rs10048665 chr2:100933085 A/G cg12002119 chr2:101014098 CHST10 0.36 5.93 0.31 7.62e-9 Intelligence (multi-trait analysis); LUSC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg20701182 chr2:24300061 SF3B14 0.88 11.35 0.53 1.86e-25 Lymphocyte counts; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg11062466 chr8:58055876 NA 0.71 8.71 0.43 1.45e-16 Developmental language disorder (linguistic errors); LUSC cis rs2732480 0.577 rs1489109 chr12:48738780 C/A cg04545296 chr12:48745243 ZNF641 0.37 6.79 0.35 5.1e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4561483 0.583 rs62038798 chr16:12001569 C/T cg08843971 chr16:11963173 GSPT1 0.42 6.32 0.33 8.53e-10 Testicular germ cell tumor; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg08888203 chr3:10149979 C3orf24 0.59 8.21 0.41 4.83e-15 Alzheimer's disease; LUSC cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg11752832 chr7:134001865 SLC35B4 0.5 7.23 0.37 3.39e-12 Mean platelet volume; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg08513622 chr7:1889785 MAD1L1 -0.36 -6.02 -0.31 4.52e-9 Schizophrenia; LUSC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs5009270 0.512 rs6977807 chr7:112249863 C/T cg23628563 chr7:112262597 NA 0.42 5.79 0.3 1.64e-8 Osteoarthritis (hip); LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg22920501 chr2:26401640 FAM59B -0.79 -11.7 -0.54 1.02e-26 Gut microbiome composition (summer); LUSC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 9.71 0.47 8.71e-20 Personality dimensions; LUSC cis rs7119167 0.901 rs6592523 chr11:73109877 T/C cg17517138 chr11:73019481 ARHGEF17 0.53 6.12 0.32 2.61e-9 Blood protein levels; LUSC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg00033643 chr7:134001901 SLC35B4 -0.43 -6.78 -0.35 5.54e-11 Mean platelet volume; LUSC cis rs8114671 0.967 rs6088753 chr20:33768252 C/T cg07148914 chr20:33460835 GGT7 0.47 6.95 0.36 1.92e-11 Height; LUSC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg06481639 chr22:41940642 POLR3H -0.53 -5.96 -0.31 6.38e-9 Vitiligo; LUSC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg24060327 chr5:131705240 SLC22A5 0.67 11.1 0.52 1.38e-24 Breast cancer; LUSC cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg19196401 chr6:110721138 DDO -0.44 -8.34 -0.42 1.92e-15 Platelet distribution width; LUSC cis rs6121246 0.909 rs6089071 chr20:30378384 C/G cg13852791 chr20:30311386 BCL2L1 0.83 11.15 0.52 9.49e-25 Mean corpuscular hemoglobin; LUSC cis rs1775715 0.870 rs3847414 chr10:32219176 A/G cg26784012 chr10:32216390 ARHGAP12 0.41 6.98 0.36 1.61e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7246967 0.673 rs34174596 chr19:22933519 G/A cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs10276303 0.519 rs6971307 chr7:3396217 T/C cg21248987 chr7:3385318 SDK1 -0.37 -6.2 -0.32 1.71e-9 Dupuytren's disease; LUSC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.09 -0.32 3.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs7582180 0.629 rs893416 chr2:100957443 G/A cg14675211 chr2:100938903 LONRF2 0.37 5.77 0.3 1.81e-8 Intelligence (multi-trait analysis); LUSC cis rs2354432 0.825 rs10900347 chr1:146800107 G/C cg25205988 chr1:146714368 CHD1L 1.05 13.29 0.59 1.24e-32 Mitochondrial DNA levels; LUSC cis rs5753618 0.561 rs2040533 chr22:31679110 G/C cg22777020 chr22:31556080 RNF185 -0.45 -5.72 -0.3 2.32e-8 Colorectal cancer; LUSC cis rs7215564 0.908 rs80183474 chr17:78655070 T/A cg23238734 chr17:78661607 RPTOR 0.48 6.13 0.32 2.5e-9 Myopia (pathological); LUSC cis rs477692 0.789 rs568166 chr10:131400088 G/A cg11019008 chr10:131425282 MGMT 0.46 6.7 0.34 8.9e-11 Response to temozolomide; LUSC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.34e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9325144 0.600 rs10880934 chr12:38730455 C/T cg13010199 chr12:38710504 ALG10B -0.48 -7.32 -0.37 1.91e-12 Morning vs. evening chronotype; LUSC cis rs12980942 1.000 rs8109167 chr19:41823167 G/T cg25627403 chr19:41769009 HNRNPUL1 0.55 5.99 0.31 5.54e-9 Coronary artery disease; LUSC cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.98 0.55 9.29e-28 Chronic sinus infection; LUSC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg00074818 chr8:8560427 CLDN23 0.58 9.87 0.48 2.46e-20 Obesity-related traits; LUSC cis rs11997175 0.784 rs36083407 chr8:33812930 G/T ch.8.33884649F chr8:33765107 NA 0.53 8.05 0.4 1.43e-14 Body mass index; LUSC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg04267008 chr7:1944627 MAD1L1 -0.61 -9.09 -0.45 9.12e-18 Bipolar disorder and schizophrenia; LUSC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg25566285 chr7:158114605 PTPRN2 -0.33 -6.15 -0.32 2.25e-9 Calcium levels; LUSC cis rs6121246 0.567 rs6120879 chr20:30202961 T/C cg21427119 chr20:30132790 HM13 -0.43 -6.19 -0.32 1.77e-9 Mean corpuscular hemoglobin; LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg18099408 chr3:52552593 STAB1 -0.4 -6.84 -0.35 3.82e-11 Bipolar disorder; LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg05788437 chr3:197476880 FYTTD1;KIAA0226 -0.45 -6.41 -0.33 4.99e-10 Height; LUSC cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg15556689 chr8:8085844 FLJ10661 0.69 11.73 0.54 7.82e-27 Mood instability; LUSC trans rs7939886 0.764 rs7113688 chr11:55946865 C/T cg03929089 chr4:120376271 NA 0.82 6.22 0.32 1.53e-9 Myopia (pathological); LUSC trans rs28647808 0.618 rs7025970 chr9:136267173 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs3733418 0.929 rs12510464 chr4:165919040 A/G cg08992305 chr4:165878219 TRIM61;C4orf39 -0.51 -5.99 -0.31 5.39e-9 Obesity-related traits; LUSC cis rs7091068 0.536 rs6583901 chr10:95409998 C/T cg20715218 chr10:95462985 C10orf4 -0.62 -8.38 -0.42 1.51e-15 Urinary tract infection frequency; LUSC cis rs2688419 0.537 rs528649 chr3:23051934 C/T cg00327796 chr3:23032191 NA 0.37 6.09 0.32 3.07e-9 Type 2 diabetes; LUSC cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs2273669 0.667 rs12216104 chr6:109317635 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg08048268 chr3:133502702 NA -0.46 -8.93 -0.44 3.01e-17 Iron status biomarkers; LUSC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.9 0.35 2.64e-11 Tonsillectomy; LUSC cis rs2795502 1.000 rs1852959 chr10:43359636 T/C cg20628663 chr10:43360327 NA 0.78 11.37 0.53 1.53e-25 Blood protein levels; LUSC cis rs10876993 0.890 rs1689597 chr12:58051886 G/A cg15848620 chr12:58087721 OS9 -0.52 -7.56 -0.38 3.89e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs1348850 0.668 rs6705405 chr2:178493713 A/G cg22681709 chr2:178499509 PDE11A -0.46 -7.63 -0.39 2.45e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg13319975 chr6:146136371 FBXO30 0.5 7.45 0.38 8.21e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs727505 0.607 rs67673811 chr7:124802694 C/G cg23710748 chr7:124431027 NA -0.37 -6.55 -0.34 2.16e-10 Lewy body disease; LUSC cis rs7715806 0.500 rs77544433 chr5:75001025 C/A cg19683494 chr5:74908142 NA 0.54 7.4 0.38 1.1e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9419702 0.568 rs7075233 chr10:133545170 A/G cg04492858 chr10:133558786 NA -0.38 -6.45 -0.33 3.9e-10 Survival in rectal cancer; LUSC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs7131987 0.834 rs1989478 chr12:29442229 C/T cg09582351 chr12:29534625 ERGIC2 -0.34 -6.96 -0.36 1.86e-11 QT interval; LUSC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.58 0.38 3.43e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs1005277 0.579 rs2472175 chr10:38382901 T/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.57 -0.46 2.51e-19 Extrinsic epigenetic age acceleration; LUSC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg21361702 chr7:150065534 REPIN1 0.59 8.6 0.43 3.13e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg18876405 chr7:65276391 NA -0.55 -8.77 -0.43 9.25e-17 Aortic root size; LUSC cis rs3808502 0.574 rs4841559 chr8:11416885 C/T cg21775007 chr8:11205619 TDH -0.57 -8.02 -0.4 1.74e-14 Neuroticism; LUSC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg03396347 chr1:1875803 NA -0.55 -12.31 -0.56 5.54e-29 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09493401 chr6:139094915 CCDC28A -0.52 -7.55 -0.38 4.06e-13 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10186029 0.509 rs10203838 chr2:213935900 T/C cg08319019 chr2:214017104 IKZF2 -0.41 -6.03 -0.31 4.3e-9 Systemic sclerosis; LUSC cis rs16917546 1.000 rs10995255 chr10:64402433 G/A cg03961010 chr10:64397487 ZNF365 -0.41 -6.5 -0.33 2.98e-10 Basal cell carcinoma; LUSC cis rs936229 0.654 rs762551 chr15:75041917 C/A cg10253484 chr15:75165896 SCAMP2 -0.47 -6.31 -0.33 8.66e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs7267979 1.000 rs13038834 chr20:25441433 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.83 17.73 0.7 4.74e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg00745463 chr17:30367425 LRRC37B -0.84 -9.79 -0.47 4.53e-20 Hip circumference adjusted for BMI; LUSC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg00031303 chr3:195681400 NA 0.7 10.07 0.48 5.22e-21 Pancreatic cancer; LUSC cis rs13401104 0.796 rs35819191 chr2:237119051 T/C cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC trans rs7819412 0.505 rs17782554 chr8:11022106 C/G cg15556689 chr8:8085844 FLJ10661 -0.52 -7.55 -0.38 4.32e-13 Triglycerides; LUSC cis rs1950626 0.787 rs34857222 chr14:101391354 G/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.41 7.24 0.37 3.17e-12 Pelvic organ prolapse (moderate/severe); LUSC cis rs7617773 0.780 rs34589064 chr3:48339549 G/A cg20734569 chr3:48348370 SPINK8 -0.46 -7.81 -0.39 7.43e-14 Coronary artery disease; LUSC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.47 6.1 0.32 2.88e-9 Renal function-related traits (BUN); LUSC cis rs1775715 0.966 rs1755067 chr10:32296195 C/T cg18675610 chr10:32216311 ARHGAP12 -0.29 -6.13 -0.32 2.5e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.59 10.02 0.48 7.91e-21 Lymphocyte counts; LUSC cis rs4073416 0.542 rs7140695 chr14:65929132 T/C cg03016385 chr14:66212404 NA -0.39 -5.76 -0.3 1.89e-8 N-glycan levels; LUSC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg12432903 chr7:1882776 MAD1L1 -0.5 -8.3 -0.41 2.69e-15 Bipolar disorder and schizophrenia; LUSC cis rs34421088 0.532 rs1545073 chr8:11167700 C/T cg21775007 chr8:11205619 TDH 0.45 6.61 0.34 1.55e-10 Neuroticism; LUSC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.44e-8 Extrinsic epigenetic age acceleration; LUSC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg20119798 chr7:94954144 PON1 -0.33 -5.78 -0.3 1.74e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2970818 0.764 rs11063181 chr12:4580657 C/A cg11146114 chr12:4671731 NA -0.69 -6.48 -0.33 3.34e-10 Phosphorus levels; LUSC cis rs597583 0.715 rs2276340 chr11:117391966 G/A cg27161313 chr11:117392002 DSCAML1 -0.51 -8.45 -0.42 9.26e-16 Putamen volume; LUSC cis rs7808935 0.768 rs757137 chr7:27989343 T/C cg22168087 chr7:27702803 HIBADH 0.45 5.85 0.31 1.15e-8 Prostate cancer; LUSC cis rs68170813 0.641 rs12532953 chr7:106865920 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg10295955 chr4:187884368 NA -1.07 -24.87 -0.81 5.49e-78 Lobe attachment (rater-scored or self-reported); LUSC cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.46 6.23 0.32 1.44e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 4.91e-23 Aortic root size; LUSC cis rs7520050 0.751 rs592214 chr1:46024505 G/A cg24296786 chr1:45957014 TESK2 0.46 6.34 0.33 7.6e-10 Red blood cell count;Reticulocyte count; LUSC cis rs6460942 0.908 rs6978857 chr7:12232665 A/G cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC cis rs73206853 0.841 rs56306150 chr12:110716775 A/T cg12870014 chr12:110450643 ANKRD13A 0.68 6.45 0.33 3.98e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7091068 0.518 rs9633674 chr10:95455431 C/T cg20715218 chr10:95462985 C10orf4 0.48 6.35 0.33 6.88e-10 Urinary tract infection frequency; LUSC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg19468946 chr17:37922297 IKZF3 -0.38 -6.18 -0.32 1.86e-9 Self-reported allergy; LUSC cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.61 0.65 1.27e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs1775715 0.870 rs11008696 chr10:32218614 G/A cg04359828 chr10:32216031 ARHGAP12 0.39 6.65 0.34 1.23e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03934478 chr11:495069 RNH1 0.87 9.53 0.46 3.33e-19 Body mass index; LUSC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg04450456 chr4:17643702 FAM184B 0.37 6.22 0.32 1.49e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg02753203 chr1:228287806 NA 0.71 12.72 0.57 1.63e-30 Diastolic blood pressure; LUSC cis rs9911578 1.000 rs2055779 chr17:57030561 A/G cg12560992 chr17:57184187 TRIM37 0.85 15.29 0.64 2.33e-40 Intelligence (multi-trait analysis); LUSC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg07636037 chr3:49044803 WDR6 0.45 6.46 0.33 3.81e-10 Resting heart rate; LUSC cis rs185694 0.779 rs609919 chr13:30895904 C/G cg07600127 chr13:30881527 KATNAL1 -0.5 -5.86 -0.31 1.1e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; LUSC trans rs208520 0.874 rs208456 chr6:66907942 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.96 -12.9 -0.58 3.55e-31 Exhaled nitric oxide output; LUSC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs2486288 0.656 rs11631021 chr15:45556829 A/G cg09092052 chr15:45571596 NA 0.45 6.43 0.33 4.35e-10 Glomerular filtration rate; LUSC trans rs877282 0.945 rs877280 chr10:771599 C/T cg22713356 chr15:30763199 NA 1.11 15.37 0.64 1.1e-40 Uric acid levels; LUSC cis rs4727027 0.736 rs12704084 chr7:148915050 C/G cg23158103 chr7:148848205 ZNF398 -0.44 -7.13 -0.36 6.27e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs3126085 0.935 rs6675889 chr1:152213066 G/A cg26876637 chr1:152193138 HRNR 0.45 6.29 0.33 9.81e-10 Atopic dermatitis; LUSC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg05623727 chr3:50126028 RBM5 -0.35 -6.66 -0.34 1.11e-10 Body mass index; LUSC cis rs34779708 0.966 rs4934737 chr10:35512799 T/C cg04310649 chr10:35416472 CREM -0.41 -6.31 -0.33 8.91e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11641365 1.000 rs11641365 chr16:88773893 A/G cg00034003 chr16:88779146 CTU2 0.55 7.72 0.39 1.39e-13 Autism spectrum disorder-related traits; LUSC cis rs16976116 0.901 rs9920220 chr15:55503982 T/C cg11288833 chr15:55489084 RSL24D1 0.5 5.95 0.31 6.81e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg11301795 chr4:187892539 NA -0.81 -15.8 -0.65 2.26e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg02018176 chr4:1364513 KIAA1530 0.48 8.47 0.42 8.06e-16 Obesity-related traits; LUSC cis rs9816226 0.645 rs16860471 chr3:185847441 G/T cg00760338 chr3:185826511 ETV5 -0.56 -7.09 -0.36 7.99e-12 Obesity;Body mass index; LUSC cis rs10986311 0.832 rs10818952 chr9:127137803 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.4 -6.36 -0.33 6.48e-10 Vitiligo; LUSC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg16506815 chr2:162101123 NA 0.42 6.28 0.32 1.07e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg08213375 chr14:104286397 PPP1R13B 0.53 10.4 0.49 4.03e-22 Schizophrenia; LUSC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg06713675 chr4:122721982 EXOSC9 -0.64 -11.34 -0.53 2.02e-25 Type 2 diabetes; LUSC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg22907277 chr7:1156413 C7orf50 0.47 7.6 0.38 2.92e-13 Longevity;Endometriosis; LUSC cis rs6938 0.534 rs59945415 chr15:75228427 C/A cg09165964 chr15:75287851 SCAMP5 0.52 7.78 0.39 9.07e-14 Breast cancer; LUSC trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg13615516 chr5:77269221 NA 0.39 6.67 0.34 1.03e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg01652190 chr22:50026171 C22orf34 -0.3 -6.09 -0.32 3.18e-9 Monocyte count;Monocyte percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00020297 chr6:17600383 FAM8A1 -0.42 -6.26 -0.32 1.18e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9311676 0.632 rs12487420 chr3:58399511 A/G cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg04166393 chr7:2884313 GNA12 0.43 5.66 0.3 3.28e-8 Height; LUSC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.76 0.39 1.03e-13 Crohn's disease; LUSC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg26304593 chr6:42947056 PEX6 -0.52 -8.11 -0.41 9.65e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs11122272 0.525 rs2739517 chr1:231537914 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.65 -10.19 -0.49 2.13e-21 Hemoglobin concentration; LUSC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.9 -0.55 1.77e-27 Extrinsic epigenetic age acceleration; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04368796 chr17:40171968 NKIRAS2 0.66 6.15 0.32 2.18e-9 Cognitive performance; LUSC trans rs6502050 0.835 rs7406529 chr17:80080877 C/T cg07393940 chr7:158741817 NA -0.38 -6.83 -0.35 4.05e-11 Life satisfaction; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.0 20.91 0.75 1.13e-62 Prudent dietary pattern; LUSC cis rs765787 0.556 rs12915965 chr15:45512647 T/C cg24006582 chr15:45444508 DUOX1 0.67 9.7 0.47 9.32e-20 Uric acid levels; LUSC cis rs2282032 0.527 rs41309248 chr14:90767386 C/T cg04374321 chr14:90722782 PSMC1 0.44 6.09 0.32 3.08e-9 Longevity; LUSC cis rs11039100 0.850 rs12792672 chr11:5833938 C/T cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9303542 0.625 rs4793889 chr17:46592352 A/G cg09704116 chr17:46666958 LOC404266 0.32 6.02 0.31 4.5e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs6952809 0.532 rs6461361 chr7:2432167 A/G cg23289794 chr7:2394357 EIF3B -0.74 -9.73 -0.47 7.49e-20 Multiple sclerosis; LUSC cis rs6496044 0.526 rs4291869 chr15:86054523 G/A cg13263323 chr15:86062960 AKAP13 -0.36 -5.99 -0.31 5.34e-9 Interstitial lung disease; LUSC cis rs68170813 0.559 rs12538090 chr7:106974647 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.64 -0.47 1.47e-19 Coronary artery disease; LUSC cis rs11048434 0.736 rs12833375 chr12:9112018 A/T cg13575925 chr12:9217583 LOC144571 0.35 6.66 0.34 1.12e-10 Sjögren's syndrome; LUSC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.59 0.34 1.72e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9393777 0.623 rs9366658 chr6:26469866 G/A cg12826209 chr6:26865740 GUSBL1 0.68 7.53 0.38 4.76e-13 Intelligence (multi-trait analysis); LUSC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg18230493 chr5:56204884 C5orf35 -0.57 -8.99 -0.44 1.83e-17 Breast cancer;Breast cancer (early onset); LUSC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.33 0.49 6.76e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs28647808 0.618 rs7025970 chr9:136267173 G/A cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs6942756 0.955 rs2056694 chr7:128923817 C/T cg02491457 chr7:128862824 NA -0.49 -6.72 -0.35 7.96e-11 White matter hyperintensity burden; LUSC cis rs1577917 0.958 rs2197648 chr6:86543887 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.99 -0.44 1.89e-17 Response to antipsychotic treatment; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs10214930 0.560 rs42089 chr7:27702940 C/T cg22168087 chr7:27702803 HIBADH -0.51 -7.1 -0.36 7.35e-12 Hypospadias; LUSC cis rs7246967 0.673 rs1433085 chr19:22811099 T/A cg23217946 chr19:22817039 ZNF492 0.45 6.33 0.33 7.68e-10 Bronchopulmonary dysplasia; LUSC cis rs11785400 0.793 rs9297970 chr8:143723386 C/T cg24634471 chr8:143751801 JRK 0.51 7.21 0.37 3.71e-12 Schizophrenia; LUSC cis rs8092503 1.000 rs12956220 chr18:52481750 A/T cg12377874 chr18:52495404 RAB27B 0.32 5.65 0.3 3.4e-8 Childhood body mass index; LUSC cis rs1949733 1.000 rs868105 chr4:8501030 G/T cg11789530 chr4:8429930 ACOX3 -0.62 -9.43 -0.46 7.08e-19 Response to antineoplastic agents; LUSC cis rs17828380 1.000 rs35884071 chr15:63477314 C/A cg05507819 chr15:63340323 TPM1 -0.75 -6.2 -0.32 1.7e-9 Social communication problems; LUSC trans rs11098499 0.865 rs9996417 chr4:120295862 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.0 0.31 5.02e-9 Corneal astigmatism; LUSC cis rs6554196 0.525 rs2192159 chr4:55505529 C/G cg18836493 chr4:55524333 KIT -0.47 -7.85 -0.39 5.85e-14 Monocyte count; LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg13685833 chr1:53393034 SCP2 0.39 5.88 0.31 9.87e-9 Monocyte count; LUSC cis rs9309473 0.950 rs17009149 chr2:73790368 T/C cg20560298 chr2:73613845 ALMS1 -0.45 -6.52 -0.34 2.66e-10 Metabolite levels; LUSC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.44 6.21 0.32 1.61e-9 Multiple sclerosis; LUSC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg02574844 chr11:5959923 NA -0.41 -5.8 -0.3 1.55e-8 DNA methylation (variation); LUSC cis rs9517320 0.534 rs9556963 chr13:99157026 G/A cg07423050 chr13:99094983 FARP1 -0.55 -10.73 -0.51 2.77e-23 Longevity; LUSC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg14552801 chr7:65878734 NA -0.37 -5.68 -0.3 2.96e-8 Aortic root size; LUSC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg13206674 chr6:150067644 NUP43 0.63 10.32 0.49 7.59e-22 Lung cancer; LUSC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg03354898 chr7:1950403 MAD1L1 -0.34 -6.52 -0.34 2.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg06453172 chr10:134556979 INPP5A -0.44 -5.67 -0.3 3.01e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9399401 0.667 rs11155242 chr6:142691549 A/C cg03128060 chr6:142623767 GPR126 0.62 10.11 0.48 3.99e-21 Chronic obstructive pulmonary disease; LUSC trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg15704280 chr7:45808275 SEPT13 -0.99 -16.69 -0.67 6.52e-46 Coronary artery disease; LUSC cis rs1385374 0.858 rs3765107 chr12:129278310 A/G cg09035930 chr12:129282057 SLC15A4 -0.64 -6.62 -0.34 1.42e-10 Systemic lupus erythematosus; LUSC cis rs80130819 0.688 rs2468945 chr12:48652414 G/A cg24011408 chr12:48396354 COL2A1 0.46 5.84 0.3 1.22e-8 Prostate cancer; LUSC cis rs4900538 0.821 rs12586673 chr14:102827643 C/T cg18135206 chr14:102964638 TECPR2 -0.99 -17.51 -0.69 3.63e-49 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs9886428 0.967 rs4831289 chr8:14122196 A/C cg11959399 chr20:741723 C20orf54 -0.39 -6.04 -0.31 4.13e-9 IgG glycosylation; LUSC cis rs11997175 0.511 rs4613957 chr8:33673130 C/T ch.8.33884649F chr8:33765107 NA -0.43 -6.32 -0.33 8.42e-10 Body mass index; LUSC cis rs2835872 0.758 rs1787401 chr21:39038893 C/T cg20424643 chr21:39039972 KCNJ6 -0.47 -7.66 -0.39 2.02e-13 Electroencephalographic traits in alcoholism; LUSC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg16339924 chr4:17578868 LAP3 0.63 9.88 0.48 2.3e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs55883249 1.000 rs56372340 chr2:9741536 A/G cg23886495 chr2:9695866 ADAM17 0.5 5.85 0.3 1.15e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9902453 0.902 rs4075014 chr17:28305674 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.68 0.43 1.75e-16 Coffee consumption (cups per day); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg08448040 chr3:13521693 HDAC11 0.49 6.43 0.33 4.31e-10 Cognitive function;Information processing speed; LUSC cis rs2324229 0.790 rs1180235 chr6:83945614 A/G cg08257003 chr6:84140564 ME1 0.27 6.35 0.33 7.05e-10 Platelet-derived growth factor BB levels; LUSC cis rs17253792 0.822 rs17683656 chr14:56053361 C/T cg01858014 chr14:56050164 KTN1 0.89 7.34 0.37 1.61e-12 Putamen volume; LUSC cis rs2880765 0.545 rs11631739 chr15:86012578 T/C cg10818794 chr15:86012489 AKAP13 -0.42 -6.55 -0.34 2.23e-10 Coronary artery disease; LUSC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg09085632 chr11:111637200 PPP2R1B -1.07 -17.76 -0.7 3.74e-50 Primary sclerosing cholangitis; LUSC cis rs4660306 0.961 rs4660862 chr1:45955056 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -7.15 -0.36 5.48e-12 Homocysteine levels; LUSC cis rs4919687 0.550 rs12784517 chr10:104464970 T/C cg04362960 chr10:104952993 NT5C2 0.47 6.86 0.35 3.35e-11 Colorectal cancer; LUSC cis rs4285028 0.699 rs7637495 chr3:121573850 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.79 -10.61 -0.5 7.31e-23 Multiple sclerosis; LUSC cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg06784218 chr1:46089804 CCDC17 -0.55 -11.21 -0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg22166914 chr1:53195759 ZYG11B 0.66 11.18 0.52 7.01e-25 Monocyte count; LUSC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg07395648 chr5:131743802 NA 0.37 5.8 0.3 1.52e-8 Asthma (sex interaction); LUSC trans rs61931739 0.649 rs1093031 chr12:33722730 C/T cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC trans rs11039798 1.000 rs7942284 chr11:48520424 A/G cg15704280 chr7:45808275 SEPT13 -0.67 -6.5 -0.34 2.85e-10 Axial length; LUSC cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg26446133 chr18:72167187 CNDP2 -0.76 -9.13 -0.45 6.87e-18 Refractive error; LUSC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg09367891 chr1:107599246 PRMT6 0.55 8.62 0.43 2.75e-16 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9527 0.545 rs35756290 chr10:104585572 G/A cg15744005 chr10:104629667 AS3MT -0.32 -5.94 -0.31 7.23e-9 Arsenic metabolism; LUSC cis rs76793172 0.920 rs77799462 chr19:46342500 G/A cg27118825 chr19:46318748 RSPH6A;SYMPK 0.46 5.83 0.3 1.32e-8 Eosinophil counts; LUSC cis rs9807841 0.617 rs892087 chr19:10794793 C/T cg09936142 chr19:10668400 KRI1 -0.42 -6.73 -0.35 7.43e-11 Inflammatory skin disease; LUSC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.81 15.41 0.64 7.74e-41 Total body bone mineral density; LUSC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg00012203 chr2:219082015 ARPC2 0.7 11.53 0.53 4.08e-26 Colorectal cancer; LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg01125463 chr6:42946178 PEX6 -0.36 -5.8 -0.3 1.55e-8 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4629710 0.592 rs9492877 chr6:131562577 C/G cg12700074 chr6:131571435 AKAP7 -0.35 -5.9 -0.31 8.89e-9 Multiple myeloma (IgH translocation); LUSC cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg08085267 chr17:45401833 C17orf57 -0.56 -8.48 -0.42 7.23e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg27266060 chr8:22091797 NA 0.4 7.38 0.37 1.23e-12 Hypertriglyceridemia; LUSC cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg05340658 chr4:99064831 C4orf37 0.69 11.84 0.54 2.99e-27 Colonoscopy-negative controls vs population controls; LUSC cis rs9921222 0.521 rs62032884 chr16:363415 C/T cg09955084 chr16:413813 NA 0.27 5.77 0.3 1.83e-8 Bone mineral density (spine);Bone mineral density; LUSC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs1808579 0.935 rs58609749 chr18:21108613 T/C cg14672496 chr18:21087552 C18orf8 0.36 6.17 0.32 1.93e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs7147624 0.683 rs8017258 chr14:66231017 C/G cg03016385 chr14:66212404 NA 0.61 6.46 0.33 3.65e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg06462663 chr19:18546047 ISYNA1 0.49 8.2 0.41 5.22e-15 Breast cancer; LUSC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12667521 chr19:29218732 NA 0.63 9.44 0.46 6.38e-19 Methadone dose in opioid dependence; LUSC cis rs9527 0.568 rs1926036 chr10:104883812 C/T cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs10992471 0.603 rs10761155 chr9:95153729 C/G cg14631576 chr9:95140430 CENPP -0.37 -6.57 -0.34 1.99e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7937682 0.889 rs497111 chr11:111499512 G/A cg22437258 chr11:111473054 SIK2 0.52 7.05 0.36 1.03e-11 Primary sclerosing cholangitis; LUSC cis rs7267979 0.966 rs3002698 chr20:25303379 C/G cg03522245 chr20:25566470 NINL -0.36 -5.76 -0.3 1.9e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7917772 0.582 rs7899004 chr10:104341435 C/T cg05855489 chr10:104503620 C10orf26 0.49 7.36 0.37 1.42e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1385374 0.858 rs10847698 chr12:129300222 T/C cg09035930 chr12:129282057 SLC15A4 -0.61 -6.58 -0.34 1.82e-10 Systemic lupus erythematosus; LUSC cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg26384229 chr12:38710491 ALG10B 0.88 14.49 0.62 2.95e-37 Drug-induced liver injury (flucloxacillin); LUSC cis rs9811920 0.598 rs793470 chr3:99548274 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 8.75 0.43 1.09e-16 Axial length; LUSC trans rs4596713 0.508 rs7467352 chr9:71766081 G/A cg25283916 chr1:242222868 NA -0.31 -6.44 -0.33 4.09e-10 Headache; LUSC cis rs6987853 0.933 rs2974352 chr8:42408483 C/T cg09913449 chr8:42400586 C8orf40 0.49 8.12 0.41 9.3e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg22117172 chr7:91764530 CYP51A1 0.33 5.81 0.3 1.49e-8 Breast cancer; LUSC cis rs6906287 0.647 rs3752581 chr6:118869730 G/A cg21191810 chr6:118973309 C6orf204 0.33 6.04 0.31 4.16e-9 Electrocardiographic conduction measures; LUSC cis rs10170310 1.000 rs10170310 chr2:139278922 C/T cg03782584 chr2:139258740 SPOPL 0.31 5.91 0.31 8.34e-9 Response to antipsychotic treatment; LUSC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg10664184 chr19:17420304 DDA1 0.47 6.19 0.32 1.75e-9 Systemic lupus erythematosus; LUSC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg17971929 chr21:40555470 PSMG1 0.8 14.09 0.61 1.04e-35 Cognitive function; LUSC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC trans rs629535 0.783 rs510632 chr8:70034570 A/G cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11030122 0.673 rs4910869 chr11:4006438 C/T cg18678763 chr11:4115507 RRM1 -0.44 -5.73 -0.3 2.19e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs3770081 1.000 rs77621359 chr2:86330353 A/C cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.92 -0.35 2.37e-11 Facial emotion recognition (sad faces); LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg07703079 chr11:430292 ANO9 0.63 6.64 0.34 1.3e-10 Body mass index; LUSC cis rs5769707 0.967 rs739248 chr22:50025205 T/C cg05373962 chr22:49881684 NA -0.44 -10.74 -0.51 2.5e-23 Monocyte count;Monocyte percentage of white cells; LUSC cis rs151234 0.741 rs11647881 chr16:28606173 C/A cg01378222 chr16:28622494 SULT1A1 -0.64 -8.14 -0.41 8.09e-15 Platelet distribution width; LUSC cis rs1018836 0.886 rs4734246 chr8:91569028 A/C cg16814680 chr8:91681699 NA -0.76 -12.82 -0.57 7.37e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1639906 0.965 rs1639908 chr7:2230644 C/G cg18044113 chr7:2236405 MAD1L1 0.3 5.68 0.3 2.89e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg21724239 chr8:58056113 NA 0.68 8.81 0.43 6.96e-17 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.863 rs1010740 chr4:120463409 C/T cg09307838 chr4:120376055 NA -0.75 -11.17 -0.52 8.19e-25 Corneal astigmatism; LUSC cis rs9296092 0.538 rs62405942 chr6:33517346 G/A cg13560919 chr6:33536144 NA -0.81 -15.57 -0.65 1.72e-41 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.73 -6.86 -0.35 3.3e-11 Cerebrospinal P-tau181p levels; LUSC cis rs16854884 0.584 rs2164554 chr3:143755528 A/G cg06585982 chr3:143692056 C3orf58 0.46 7.06 0.36 9.42e-12 Economic and political preferences (feminism/equality); LUSC cis rs9905704 0.681 rs7225128 chr17:56636854 T/C cg12560992 chr17:57184187 TRIM37 -0.51 -5.9 -0.31 8.83e-9 Testicular germ cell tumor; LUSC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.16 -0.32 2.13e-9 Life satisfaction; LUSC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs1801251 1.000 rs56777991 chr2:233635388 A/C cg25237894 chr2:233734115 C2orf82 0.35 6.42 0.33 4.67e-10 Coronary artery disease; LUSC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg13010344 chr12:123464640 ARL6IP4 -0.5 -8.08 -0.4 1.21e-14 Platelet count; LUSC cis rs2692947 0.794 rs2692893 chr2:96756547 C/T cg23100626 chr2:96804247 ASTL 0.31 7.52 0.38 5.05e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9486719 0.857 rs3798293 chr6:97033370 A/G cg06623918 chr6:96969491 KIAA0776 -0.82 -11.62 -0.54 1.97e-26 Migraine;Coronary artery disease; LUSC cis rs9473147 0.503 rs2171086 chr6:47590104 C/T cg20196966 chr6:47445060 CD2AP 0.44 6.13 0.32 2.46e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg22532475 chr10:104410764 TRIM8 0.32 7.12 0.36 6.45e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6430585 0.697 rs6724569 chr2:136516970 G/A cg07169764 chr2:136633963 MCM6 1.18 17.48 0.69 4.99e-49 Corneal structure; LUSC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.01 0.44 1.63e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs500891 0.525 rs1591396 chr6:84107897 T/C cg08257003 chr6:84140564 ME1 0.34 8.29 0.41 2.85e-15 Platelet-derived growth factor BB levels; LUSC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg22442454 chr1:209979470 IRF6 0.42 5.77 0.3 1.77e-8 Cleft lip with or without cleft palate; LUSC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg05754148 chr16:3507555 NAT15 0.58 8.53 0.42 5.18e-16 Tuberculosis; LUSC cis rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05901451 chr6:126070800 HEY2 0.59 8.99 0.44 1.86e-17 Endometrial cancer; LUSC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg26958806 chr6:27640298 NA 0.67 5.88 0.31 1.01e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg09655341 chr17:79618100 PDE6G -0.3 -6.86 -0.35 3.27e-11 Eye color traits; LUSC cis rs7927592 0.513 rs531163 chr11:68194496 A/G cg16797656 chr11:68205561 LRP5 0.47 8.45 0.42 8.91e-16 Total body bone mineral density; LUSC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg14552801 chr7:65878734 NA -0.37 -5.82 -0.3 1.42e-8 Aortic root size; LUSC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg25838465 chr1:92012736 NA -0.75 -15.6 -0.65 1.34e-41 Breast cancer; LUSC cis rs4474465 1.000 rs2373199 chr11:78142982 G/A cg27205649 chr11:78285834 NARS2 -0.53 -6.18 -0.32 1.84e-9 Alzheimer's disease (survival time); LUSC trans rs8073060 0.586 rs6505485 chr17:33996102 C/T cg19694781 chr19:47549865 TMEM160 -1.14 -18.02 -0.7 3.5e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs3784262 0.512 rs4646572 chr15:58343021 T/C cg12031962 chr15:58353849 ALDH1A2 -0.37 -6.74 -0.35 6.81e-11 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.61 -0.38 2.74e-13 Neuroticism; LUSC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg18225595 chr11:63971243 STIP1 0.49 6.1 0.32 2.88e-9 Mean platelet volume; LUSC cis rs9788682 0.948 rs59133824 chr15:78833450 C/A cg24631222 chr15:78858424 CHRNA5 0.83 11.44 0.53 8.32e-26 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs561341 1.000 rs7216102 chr17:30259450 A/G cg20587970 chr11:113659929 NA -0.98 -13.44 -0.59 3.25e-33 Hip circumference adjusted for BMI; LUSC cis rs3806843 1.000 rs3733710 chr5:140167463 C/T cg26395211 chr5:140044315 WDR55 -0.37 -5.78 -0.3 1.74e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg05347473 chr6:146136440 FBXO30 -0.49 -8.27 -0.41 3.27e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs9814567 0.929 rs9855013 chr3:134240414 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.74 -0.6 2.4e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.45 0.38 8.27e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.63 -8.59 -0.43 3.4e-16 Systemic lupus erythematosus; LUSC cis rs1507153 0.775 rs9361413 chr6:79345249 A/G cg05283184 chr6:79620031 NA -0.43 -7.45 -0.38 7.95e-13 Sjögren's syndrome; LUSC cis rs10504073 0.584 rs4873092 chr8:49974053 T/C cg00325661 chr8:49890786 NA 0.69 11.04 0.52 2.33e-24 Blood metabolite ratios; LUSC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg12463550 chr7:65579703 CRCP -0.45 -6.65 -0.34 1.17e-10 Aortic root size; LUSC cis rs694739 0.894 rs11601860 chr11:64110422 A/T cg23796481 chr11:64053134 BAD;GPR137 0.61 9.92 0.48 1.68e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs708547 0.836 rs1713997 chr4:57843863 G/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.57 -7.73 -0.39 1.28e-13 Response to bleomycin (chromatid breaks); LUSC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg20203395 chr5:56204925 C5orf35 0.58 8.59 0.43 3.43e-16 Initial pursuit acceleration; LUSC cis rs7100689 0.577 rs9285726 chr10:82035150 A/T cg01528321 chr10:82214614 TSPAN14 0.95 14.47 0.62 3.61e-37 Post bronchodilator FEV1; LUSC cis rs2797160 1.000 rs4895798 chr6:126000162 A/G cg05901451 chr6:126070800 HEY2 -0.58 -8.7 -0.43 1.5e-16 Endometrial cancer; LUSC cis rs765787 0.530 rs4331289 chr15:45515338 C/T cg25801113 chr15:45476975 SHF 0.35 7.32 0.37 1.82e-12 Uric acid levels; LUSC cis rs9398803 0.865 rs2050644 chr6:126805255 A/G cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.88e-9 Male-pattern baldness; LUSC cis rs765787 0.505 rs12593605 chr15:45497448 T/A cg24006582 chr15:45444508 DUOX1 0.7 10.01 0.48 8.51e-21 Uric acid levels; LUSC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg21984481 chr17:79567631 NPLOC4 -0.68 -14.27 -0.62 2.02e-36 Eye color traits; LUSC cis rs2637266 0.783 rs720249 chr10:78476143 T/C cg18941641 chr10:78392320 NA 0.34 6.21 0.32 1.61e-9 Pulmonary function; LUSC cis rs9467773 0.967 rs9467775 chr6:26513435 G/A cg05738196 chr6:26577821 NA 0.81 15.7 0.65 5.52e-42 Intelligence (multi-trait analysis); LUSC cis rs950776 0.518 rs2869544 chr15:78839400 G/A cg22563815 chr15:78856949 CHRNA5 -0.27 -6.4 -0.33 5.4e-10 Sudden cardiac arrest; LUSC cis rs34779708 0.966 rs17500582 chr10:35498788 T/A cg03585969 chr10:35415529 CREM 0.64 9.5 0.46 4.23e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3845702 0.673 rs12468986 chr2:180862320 T/G cg01881094 chr2:180872142 CWC22 1.03 12.16 0.55 2.04e-28 Schizophrenia; LUSC cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg13531842 chr10:38383804 ZNF37A -0.45 -7.02 -0.36 1.21e-11 Extrinsic epigenetic age acceleration; LUSC trans rs7618501 0.633 rs7628058 chr3:50039474 C/T cg21659725 chr3:3221576 CRBN 0.63 10.57 0.5 1.04e-22 Intelligence (multi-trait analysis); LUSC cis rs2836633 0.965 rs2836621 chr21:40054149 C/T cg12884169 chr21:40033163 ERG 0.59 12.03 0.55 6.13e-28 Coronary artery disease; LUSC cis rs4804416 1.000 rs4804416 chr19:7223848 G/T cg09779027 chr19:7224513 INSR -0.3 -6.02 -0.31 4.72e-9 Thyroid hormone levels;Hypothyroidism; LUSC cis rs2730245 0.527 rs2527187 chr7:158716912 T/C cg11984989 chr7:158649758 WDR60 -1.07 -13.12 -0.58 5.11e-32 Height; LUSC trans rs800082 0.516 rs1178894 chr3:144239854 A/G cg24215973 chr2:240111563 HDAC4 0.44 6.81 0.35 4.59e-11 Smoking behavior; LUSC cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg24558204 chr6:135376177 HBS1L 0.67 10.36 0.49 5.35e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs11098499 0.863 rs1480936 chr4:120462861 C/T cg24375607 chr4:120327624 NA 0.76 11.19 0.52 6.99e-25 Corneal astigmatism; LUSC cis rs3820068 0.581 rs12385690 chr1:15932932 A/T cg24675056 chr1:15929824 NA 0.53 9.47 0.46 5.12e-19 Systolic blood pressure; LUSC cis rs1107366 1.000 rs9874508 chr3:125902417 A/G cg01346077 chr3:125931526 NA -0.35 -6.81 -0.35 4.46e-11 Metabolite levels; LUSC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg12963246 chr6:28129442 ZNF389 0.56 7.89 0.4 4.28e-14 Parkinson's disease; LUSC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg22166914 chr1:53195759 ZYG11B -0.48 -7.74 -0.39 1.18e-13 Monocyte count; LUSC cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.77 0.3 1.77e-8 Breast cancer; LUSC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg06238570 chr21:40685208 BRWD1 -0.63 -10.67 -0.5 4.51e-23 Cognitive function; LUSC cis rs6066835 1.000 rs6095247 chr20:47320835 T/C cg18078177 chr20:47281410 PREX1 0.71 5.96 0.31 6.29e-9 Multiple myeloma; LUSC cis rs2463822 0.669 rs72919496 chr11:62052730 T/C cg06239285 chr11:62104954 ASRGL1 -0.72 -6.87 -0.35 3.15e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg02503808 chr4:7069936 GRPEL1 -0.98 -12.93 -0.58 2.76e-31 Monocyte percentage of white cells; LUSC cis rs34779708 0.931 rs12771399 chr10:35452377 C/T cg03585969 chr10:35415529 CREM 0.61 8.85 0.44 5.37e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs1347297 0.526 rs10201175 chr2:179265348 C/T cg14011486 chr1:26737247 LIN28 0.44 6.93 0.35 2.22e-11 Alzheimer disease and age of onset; LUSC cis rs12579753 0.917 rs12372724 chr12:82193628 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs6500395 0.962 rs3743780 chr16:48647480 A/G cg04672837 chr16:48644449 N4BP1 0.47 6.91 0.35 2.43e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -5.98 -0.31 5.63e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs977987 0.806 rs1364077 chr16:75396991 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.91 -0.35 2.52e-11 Dupuytren's disease; LUSC cis rs7000551 0.527 rs11783730 chr8:22244897 C/T cg12081754 chr8:22256438 SLC39A14 0.97 15.19 0.64 5.68e-40 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs7267979 0.873 rs7453 chr20:25207074 A/G cg08601574 chr20:25228251 PYGB 0.47 7.32 0.37 1.83e-12 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2073300 1.000 rs6137961 chr20:23443102 G/T cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7584330 0.704 rs7598954 chr2:238364776 C/T cg14458575 chr2:238380390 NA 0.86 15.24 0.64 3.37e-40 Prostate cancer; LUSC cis rs4909189 1.000 rs62493651 chr7:158135592 T/C cg23298862 chr7:158159286 PTPRN2 0.32 5.66 0.3 3.27e-8 Response to amphetamines; LUSC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg23590916 chr17:43697445 MGC57346 0.5 6.7 0.34 9.07e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3106136 0.967 rs13135934 chr4:95207688 G/C cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.17 -0.32 1.99e-9 Capecitabine sensitivity; LUSC cis rs2354432 0.556 rs11239964 chr1:146753902 G/C cg25205988 chr1:146714368 CHD1L -1.04 -9.38 -0.46 1.05e-18 Mitochondrial DNA levels; LUSC cis rs6545883 0.859 rs2694644 chr2:61604856 A/T cg15711740 chr2:61764176 XPO1 0.41 6.3 0.33 9.61e-10 Tuberculosis; LUSC cis rs17270561 0.609 rs4712965 chr6:25742022 G/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs6456156 0.586 rs6909180 chr6:167460537 A/G cg07741184 chr6:167504864 NA 0.39 6.95 0.36 1.96e-11 Primary biliary cholangitis; LUSC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.91e-9 Major depressive disorder; LUSC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg17385448 chr1:15911702 AGMAT 0.36 6.16 0.32 2.06e-9 Systolic blood pressure; LUSC trans rs7647973 0.626 rs2131108 chr3:49665390 C/T cg21659725 chr3:3221576 CRBN -0.68 -8.22 -0.41 4.6e-15 Menarche (age at onset); LUSC cis rs6693567 0.545 rs1694386 chr1:150377965 C/G cg15654264 chr1:150340011 RPRD2 0.45 7.19 0.37 4.26e-12 Migraine; LUSC cis rs10504073 0.647 rs12546839 chr8:50009020 C/T cg00325661 chr8:49890786 NA 0.62 9.9 0.48 1.99e-20 Blood metabolite ratios; LUSC cis rs11758351 0.660 rs11753655 chr6:26220109 C/T cg01420254 chr6:26195488 NA 0.65 7.28 0.37 2.44e-12 Gout;Renal underexcretion gout; LUSC cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg11266682 chr4:10021025 SLC2A9 0.57 10.21 0.49 1.74e-21 Bone mineral density; LUSC cis rs11676348 0.846 rs4674257 chr2:218988774 A/G cg00012203 chr2:219082015 ARPC2 -0.57 -9.06 -0.44 1.11e-17 Ulcerative colitis; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.38 6.31 0.33 8.86e-10 Electroencephalogram traits; LUSC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg21280719 chr6:42927975 GNMT -0.32 -7.81 -0.39 7.38e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs35306767 0.623 rs72760941 chr10:1141244 A/G cg20503657 chr10:835505 NA 0.52 6.32 0.33 8.27e-10 Eosinophil percentage of granulocytes; LUSC cis rs4974559 0.947 rs28678404 chr4:1374919 G/A cg02980000 chr4:1222292 CTBP1 0.73 6.5 0.34 2.95e-10 Systolic blood pressure; LUSC cis rs11077998 0.840 rs9894993 chr17:80481088 T/C cg10255544 chr17:80519551 FOXK2 0.41 6.64 0.34 1.28e-10 Reticulocyte fraction of red cells; LUSC cis rs4642101 0.512 rs9813960 chr3:12818205 A/G cg05775895 chr3:12838266 CAND2 0.52 9.06 0.44 1.08e-17 QRS complex (12-leadsum); LUSC cis rs3770081 1.000 rs75109362 chr2:86289889 G/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.05 -6.84 -0.35 3.84e-11 Facial emotion recognition (sad faces); LUSC trans rs1493916 0.905 rs4799727 chr18:31393095 T/G cg13755796 chr4:20253514 NA -0.45 -6.99 -0.36 1.53e-11 Life satisfaction; LUSC cis rs1044826 0.597 rs6803593 chr3:139193987 T/C cg15131784 chr3:139108705 COPB2 0.4 6.38 0.33 5.77e-10 Obesity-related traits; LUSC cis rs10886558 0.502 rs10788026 chr10:121827450 C/T cg02041677 chr10:121771263 NA -0.32 -5.9 -0.31 8.79e-9 Shingles; LUSC cis rs3126085 0.935 rs10888466 chr1:152166223 A/C cg26876637 chr1:152193138 HRNR -0.46 -6.78 -0.35 5.58e-11 Atopic dermatitis; LUSC cis rs9527 0.640 rs35195396 chr10:104928770 T/A cg23093090 chr10:104574429 C10orf26 -0.35 -6.41 -0.33 4.97e-10 Arsenic metabolism; LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg13560548 chr3:10150139 C3orf24 0.49 6.59 0.34 1.76e-10 Alzheimer's disease; LUSC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg17376030 chr22:41985996 PMM1 -0.47 -5.81 -0.3 1.49e-8 Vitiligo; LUSC cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg22117172 chr7:91764530 CYP51A1 0.32 5.72 0.3 2.42e-8 Breast cancer; LUSC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs9393692 1.000 rs2393593 chr6:26285683 T/C cg00631329 chr6:26305371 NA -0.49 -9.52 -0.46 3.63e-19 Educational attainment; LUSC cis rs317689 0.788 rs317679 chr12:69693172 A/C cg11871910 chr12:69753446 YEATS4 0.48 6.48 0.33 3.35e-10 Response to diuretic therapy; LUSC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg00800038 chr16:89945340 TCF25 -0.75 -6.64 -0.34 1.26e-10 Skin colour saturation; LUSC cis rs11250098 0.503 rs7821826 chr8:10769439 C/T cg21775007 chr8:11205619 TDH -0.5 -6.79 -0.35 5.17e-11 Morning vs. evening chronotype; LUSC cis rs57590327 0.503 rs1524557 chr3:81892031 A/G cg07356753 chr3:81810745 GBE1 -0.61 -9.62 -0.47 1.73e-19 Extraversion; LUSC cis rs3916 0.911 rs34673751 chr12:121171891 G/A cg02419362 chr12:121203948 SPPL3 0.36 5.67 0.3 3.05e-8 Urinary metabolites (H-NMR features); LUSC cis rs3741151 1.000 rs79794992 chr11:73049352 A/G cg17517138 chr11:73019481 ARHGEF17 1.12 9.16 0.45 5.39e-18 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs6089829 0.962 rs3899032 chr20:61658542 G/A cg15934090 chr1:100435551 SLC35A3 0.47 7.72 0.39 1.4e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg20203395 chr5:56204925 C5orf35 -0.57 -8.55 -0.42 4.43e-16 Initial pursuit acceleration; LUSC cis rs11958404 0.932 rs6870115 chr5:157436960 T/C cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs11098499 0.908 rs11098527 chr4:120399906 A/G cg09307838 chr4:120376055 NA 0.78 11.23 0.52 4.76e-25 Corneal astigmatism; LUSC trans rs7824557 0.806 rs10503418 chr8:11118983 C/T cg08975724 chr8:8085496 FLJ10661 -0.49 -7.51 -0.38 5.56e-13 Retinal vascular caliber; LUSC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg23622369 chr17:40706682 HSD17B1 -0.38 -6.21 -0.32 1.58e-9 Colorectal or endometrial cancer; LUSC cis rs34421088 0.506 rs2117616 chr8:11145911 A/G cg21775007 chr8:11205619 TDH -0.45 -5.75 -0.3 1.98e-8 Neuroticism; LUSC cis rs4555082 0.830 rs2816648 chr14:105708289 C/T cg13114125 chr14:105738426 BRF1 -0.94 -16.25 -0.66 3.63e-44 Mean platelet volume;Platelet distribution width; LUSC cis rs13315871 1.000 rs9864325 chr3:58336846 A/C cg12435725 chr3:58293450 RPP14 -0.7 -7.64 -0.39 2.28e-13 Cholesterol, total; LUSC cis rs8072100 0.764 rs4794371 chr17:45627693 G/C cg08085267 chr17:45401833 C17orf57 0.55 8.89 0.44 3.85e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1577917 1.000 rs35761942 chr6:86629504 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.92 -0.35 2.39e-11 Response to antipsychotic treatment; LUSC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 9.57 0.46 2.52e-19 Menopause (age at onset); LUSC cis rs9910055 0.659 rs186603 chr17:42207884 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.58 -9.14 -0.45 6.35e-18 Total body bone mineral density; LUSC trans rs61931739 0.500 rs11053222 chr12:34481100 C/A cg13010199 chr12:38710504 ALG10B 0.68 10.74 0.51 2.68e-23 Morning vs. evening chronotype; LUSC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg10802521 chr3:52805072 NEK4 -0.55 -8.77 -0.43 9.4e-17 Bipolar disorder; LUSC cis rs4268898 0.571 rs1986478 chr2:24468545 G/A cg06627628 chr2:24431161 ITSN2 -0.87 -12.8 -0.57 8.73e-31 Asthma; LUSC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg16850897 chr7:100343110 ZAN -0.56 -8.07 -0.4 1.32e-14 Other erythrocyte phenotypes; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg08736216 chr1:53307985 ZYG11A 0.3 6.19 0.32 1.78e-9 Monocyte count; LUSC cis rs9291683 0.526 rs7695555 chr4:10001656 T/C cg11266682 chr4:10021025 SLC2A9 0.43 7.33 0.37 1.7e-12 Bone mineral density; LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12681287 0.752 rs4427148 chr8:87250668 G/A cg27223183 chr8:87520930 FAM82B -0.45 -5.75 -0.3 2.03e-8 Caudate activity during reward; LUSC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.71 -9.31 -0.45 1.74e-18 Chronic sinus infection; LUSC cis rs6087990 0.871 rs4911252 chr20:31330115 A/G cg13636640 chr20:31349939 DNMT3B -0.98 -21.65 -0.76 1.43e-65 Ulcerative colitis; LUSC cis rs72960926 0.744 rs56405366 chr6:75035257 T/C cg03266952 chr6:74778945 NA -0.84 -7.05 -0.36 1.01e-11 Metabolite levels (MHPG); LUSC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC trans rs890100 0.736 rs2033015 chr2:56702871 A/T cg01657744 chr10:88471748 LDB3 -0.44 -6.19 -0.32 1.79e-9 Gut microbiome composition (summer); LUSC cis rs7267979 0.966 rs2500417 chr20:25383287 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.78 -0.7 2.97e-50 Liver enzyme levels (alkaline phosphatase); LUSC trans rs9467711 0.606 rs4634439 chr6:26598004 C/T cg06606381 chr12:133084897 FBRSL1 0.64 6.83 0.35 4.06e-11 Autism spectrum disorder or schizophrenia; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg21076271 chr14:32546633 ARHGAP5;C14orf128 0.42 6.81 0.35 4.67e-11 Triglycerides; LUSC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg00814883 chr7:100076585 TSC22D4 -0.69 -9.31 -0.45 1.71e-18 Platelet count; LUSC cis rs9814567 0.929 rs9838834 chr3:134207077 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.61 -0.6 7.24e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg09021430 chr5:549028 NA -0.57 -7.7 -0.39 1.61e-13 Obesity-related traits; LUSC trans rs9388451 0.537 rs1739383 chr6:126098915 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.74 -12.86 -0.58 4.86e-31 Brugada syndrome; LUSC cis rs2235642 0.525 rs8048290 chr16:1562026 T/C cg26528668 chr16:1614120 IFT140 0.41 6.03 0.31 4.43e-9 Coronary artery disease; LUSC cis rs896854 0.902 rs726816 chr8:95968413 T/G cg09323728 chr8:95962352 TP53INP1 -0.43 -8.74 -0.43 1.15e-16 Type 2 diabetes; LUSC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg11764359 chr7:65958608 NA -0.6 -8.86 -0.44 4.92e-17 Aortic root size; LUSC cis rs4077515 0.874 rs3812575 chr9:139293259 T/C cg14019695 chr9:139328340 INPP5E 0.44 8.2 0.41 5.3e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg09034736 chr1:150693464 HORMAD1 0.45 6.48 0.33 3.36e-10 Melanoma; LUSC trans rs225245 0.817 rs1634684 chr17:33941051 A/G cg19694781 chr19:47549865 TMEM160 -0.42 -6.65 -0.34 1.19e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg01448562 chr3:133502909 NA -0.53 -7.84 -0.39 6.2e-14 Iron status biomarkers; LUSC cis rs7100689 0.646 rs11202721 chr10:82135762 G/A cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs7615952 0.611 rs9681518 chr3:125615130 A/G cg05084668 chr3:125655381 ALG1L -0.89 -12.79 -0.57 9.46e-31 Blood pressure (smoking interaction); LUSC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg05313129 chr8:58192883 C8orf71 -0.51 -6.64 -0.34 1.26e-10 Developmental language disorder (linguistic errors); LUSC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg15744005 chr10:104629667 AS3MT -0.28 -6.11 -0.32 2.76e-9 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4919694 1.000 rs75691516 chr10:104652045 C/T cg04362960 chr10:104952993 NT5C2 1.1 12.99 0.58 1.63e-31 Arsenic metabolism; LUSC cis rs2439831 0.867 rs3809481 chr15:43662829 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.58 0.42 3.75e-16 Lung cancer in ever smokers; LUSC trans rs2840044 1.000 rs2840044 chr17:33892068 A/G cg19694781 chr19:47549865 TMEM160 0.59 9.56 0.46 2.64e-19 Response to radiotherapy in cancer (late toxicity); LUSC cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.39 0.49 4.4e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11864453 0.713 rs2241412 chr16:72144284 A/G cg16558253 chr16:72132732 DHX38 -0.37 -5.76 -0.3 1.9e-8 Fibrinogen levels; LUSC trans rs877282 0.945 rs11253390 chr10:788678 A/G cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs11676348 0.838 rs17844697 chr2:218999255 G/A cg06547715 chr2:218990976 CXCR2 0.31 5.85 0.31 1.14e-8 Ulcerative colitis; LUSC cis rs6785206 0.803 rs2712380 chr3:128338661 A/C cg16766828 chr3:128327626 NA -0.7 -7.66 -0.39 2.01e-13 Lymphocyte percentage of white cells; LUSC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg00074818 chr8:8560427 CLDN23 0.57 9.67 0.47 1.14e-19 Obesity-related traits; LUSC cis rs1577917 0.655 rs9450311 chr6:86376586 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 7.29 0.37 2.24e-12 Response to antipsychotic treatment; LUSC cis rs593982 0.858 rs537385 chr11:65504900 G/A cg08755490 chr11:65554678 OVOL1 1.41 17.72 0.7 5.44e-50 Atopic dermatitis; LUSC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg06022373 chr22:39101656 GTPBP1 0.89 14.68 0.63 5.52e-38 Menopause (age at onset); LUSC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg17294928 chr15:75287854 SCAMP5 -0.92 -12.84 -0.57 5.9e-31 Blood trace element (Zn levels); LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg08859206 chr1:53392774 SCP2 -0.5 -8.55 -0.42 4.59e-16 Monocyte count; LUSC cis rs10746514 1.000 rs12129814 chr1:232251730 C/A cg09506761 chr1:232265262 NA 0.51 8.37 0.42 1.64e-15 Response to statin therapy; LUSC cis rs7215564 0.818 rs4889878 chr17:78662479 G/T cg23238734 chr17:78661607 RPTOR 0.45 5.81 0.3 1.49e-8 Myopia (pathological); LUSC cis rs694739 0.628 rs538147 chr11:64129722 G/A cg23796481 chr11:64053134 BAD;GPR137 0.51 8.07 0.4 1.3e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.62 -8.36 -0.42 1.68e-15 Lung function (FEV1/FVC); LUSC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg02428538 chr16:24856791 SLC5A11 -0.51 -6.0 -0.31 5.09e-9 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg03806693 chr22:41940476 POLR3H -0.9 -12.72 -0.57 1.64e-30 Vitiligo; LUSC cis rs11764590 0.694 rs3996323 chr7:2079428 G/T cg19629631 chr7:2060116 MAD1L1 -0.35 -5.7 -0.3 2.65e-8 Neuroticism; LUSC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg03676636 chr4:99064102 C4orf37 0.3 6.48 0.33 3.37e-10 Colonoscopy-negative controls vs population controls; LUSC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg05368731 chr17:41323189 NBR1 0.93 16.11 0.66 1.32e-43 Menopause (age at onset); LUSC cis rs698833 0.521 rs35627501 chr2:44506971 G/C cg04920474 chr2:44395004 PPM1B 0.55 9.05 0.44 1.23e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs6120849 0.754 rs11167253 chr20:33614449 T/C cg24642439 chr20:33292090 TP53INP2 0.61 6.74 0.35 6.84e-11 Protein C levels; LUSC cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg20503657 chr10:835505 NA -0.51 -7.01 -0.36 1.36e-11 Response to angiotensin II receptor blocker therapy; LUSC cis rs9527 0.590 rs7897663 chr10:104905604 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs8048589 0.660 rs11075054 chr16:12216295 C/A cg02910054 chr16:12241554 SNX29 0.46 5.97 0.31 6.22e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg20476274 chr7:133979776 SLC35B4 0.82 14.95 0.63 4.64e-39 Mean platelet volume; LUSC cis rs854765 0.547 rs6502633 chr17:17941037 G/C cg04398451 chr17:18023971 MYO15A -0.57 -9.5 -0.46 4.2e-19 Total body bone mineral density; LUSC cis rs709400 0.658 rs72708874 chr14:103899251 T/G cg12935359 chr14:103987150 CKB -0.57 -8.56 -0.42 4.26e-16 Body mass index; LUSC trans rs28647808 0.786 rs4962134 chr9:136256626 G/A cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs902774 0.554 rs4919749 chr12:53358034 C/T cg14581129 chr12:53358946 NA -0.56 -7.84 -0.39 6.19e-14 Prostate cancer; LUSC cis rs10876993 0.893 rs4760168 chr12:58087737 T/G cg15848620 chr12:58087721 OS9 -0.57 -8.13 -0.41 8.39e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs477692 1.000 rs548390 chr10:131417427 G/A cg11019008 chr10:131425282 MGMT 0.4 5.99 0.31 5.55e-9 Response to temozolomide; LUSC cis rs12579753 1.000 rs11115047 chr12:82232773 C/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.17e-9 Resting heart rate; LUSC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg06637938 chr14:75390232 RPS6KL1 0.49 7.43 0.38 9.37e-13 Height; LUSC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg12463550 chr7:65579703 CRCP -0.55 -8.03 -0.4 1.68e-14 Aortic root size; LUSC cis rs10911251 0.528 rs10911248 chr1:183080564 G/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.92 0.51 6.09e-24 Colorectal cancer; LUSC cis rs4925386 0.681 rs2427294 chr20:60927257 G/A cg03359095 chr20:61002866 C20orf151 -0.29 -5.65 -0.3 3.53e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs427941 0.703 rs201457 chr7:101741338 C/A cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg25427524 chr10:38739819 LOC399744 -0.57 -10.02 -0.48 7.76e-21 Extrinsic epigenetic age acceleration; LUSC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC trans rs800082 0.674 rs4681328 chr3:144190767 C/G cg24215973 chr2:240111563 HDAC4 0.41 5.97 0.31 6.07e-9 Smoking behavior; LUSC trans rs564343 0.563 rs574335 chr11:65833266 C/T cg26701943 chr11:108369231 KDELC2 0.44 6.05 0.31 3.96e-9 Obesity (early onset extreme); LUSC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg14092988 chr3:52407081 DNAH1 0.33 6.4 0.33 5.28e-10 Bipolar disorder; LUSC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg26752003 chr8:145688521 CYHR1 -0.6 -10.08 -0.48 5.03e-21 Age at first birth; LUSC cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg23583168 chr7:148888333 NA -0.86 -14.86 -0.63 1.04e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC trans rs8072100 0.748 rs9912592 chr17:45556945 G/A cg03886242 chr7:26192032 NFE2L3 -0.42 -6.64 -0.34 1.25e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs236907 0.859 rs17650340 chr1:171757921 A/T cg13482142 chr2:234261155 NA 0.48 5.95 0.31 6.7e-9 Mean platelet volume; LUSC trans rs1459104 0.866 rs66989058 chr11:54823043 C/A cg15704280 chr7:45808275 SEPT13 0.72 6.3 0.33 9.53e-10 Body mass index; LUSC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg16606324 chr3:10149918 C3orf24 0.67 9.78 0.47 4.99e-20 Alzheimer's disease; LUSC cis rs73206853 0.640 rs2098140 chr12:110726081 T/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.52 0.34 2.63e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg13683864 chr3:40499215 RPL14 0.98 16.68 0.67 7.24e-46 Renal cell carcinoma; LUSC cis rs3849570 0.961 rs11915042 chr3:81834060 G/A cg07356753 chr3:81810745 GBE1 -0.68 -11.09 -0.52 1.46e-24 Waist circumference;Body mass index; LUSC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg26408565 chr15:76604113 ETFA -0.48 -7.55 -0.38 4.07e-13 Blood metabolite levels; LUSC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg22535103 chr8:58192502 C8orf71 -0.78 -7.98 -0.4 2.41e-14 Developmental language disorder (linguistic errors); LUSC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg20821713 chr7:1055600 C7orf50 -0.56 -7.29 -0.37 2.2e-12 Bronchopulmonary dysplasia; LUSC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg27170947 chr2:26402098 FAM59B -0.62 -9.26 -0.45 2.58e-18 Gut microbiome composition (summer); LUSC cis rs11098499 0.954 rs10008392 chr4:120318839 G/A cg09307838 chr4:120376055 NA 0.79 11.22 0.52 5.45e-25 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07545535 chr7:76256818 POMZP3;LOC100133091 -0.43 -6.48 -0.33 3.38e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg24829409 chr8:58192753 C8orf71 -0.46 -5.73 -0.3 2.2e-8 Developmental language disorder (linguistic errors); LUSC cis rs11758351 0.660 rs77337633 chr6:26233610 T/C cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs9790314 1.000 rs163328 chr3:161073599 A/G cg04691961 chr3:161091175 C3orf57 -0.36 -6.24 -0.32 1.35e-9 Morning vs. evening chronotype; LUSC cis rs17270561 0.609 rs9393658 chr6:25730438 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.55 0.38 4.06e-13 Iron status biomarkers; LUSC cis rs7189233 0.531 rs13332406 chr16:53489705 G/A cg09728985 chr16:53543985 NA -0.31 -5.81 -0.3 1.46e-8 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg15704280 chr7:45808275 SEPT13 -0.86 -14.43 -0.62 5.1e-37 Height; LUSC cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg12219531 chr12:120966889 COQ5 0.6 8.02 0.4 1.85e-14 High light scatter reticulocyte count; LUSC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg09455208 chr3:40491958 NA 0.59 10.38 0.49 4.46e-22 Renal cell carcinoma; LUSC cis rs154659 0.961 rs164739 chr16:89667699 C/G cg01710450 chr16:89662404 CPNE7 -0.43 -6.58 -0.34 1.79e-10 Tanning; LUSC cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg00852783 chr1:26633632 UBXN11 0.61 9.67 0.47 1.18e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg07092213 chr7:1199455 ZFAND2A -0.67 -10.84 -0.51 1.18e-23 Longevity;Endometriosis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg17474435 chr12:50135167 TMBIM6 0.45 6.25 0.32 1.28e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg24154853 chr7:158122151 PTPRN2 -0.42 -8.24 -0.41 4.06e-15 Calcium levels; LUSC cis rs6463523 0.933 rs79984239 chr7:766220 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 1.01 20.88 0.75 1.6e-62 Subjective well-being; LUSC trans rs11992162 0.967 rs10112888 chr8:11830208 G/C cg06636001 chr8:8085503 FLJ10661 0.56 8.27 0.41 3.13e-15 Monocyte count; LUSC cis rs6665290 0.904 rs3738729 chr1:227191227 C/T cg10327440 chr1:227177885 CDC42BPA -1.22 -40.05 -0.91 1.39e-129 Myeloid white cell count; LUSC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg25019033 chr10:957182 NA -0.53 -7.03 -0.36 1.2e-11 Eosinophil percentage of granulocytes; LUSC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg08508325 chr11:3079039 CARS 0.49 12.34 0.56 4.56e-29 Longevity; LUSC cis rs11583043 0.708 rs874905 chr1:101539702 G/A cg11406453 chr1:101602562 NA -0.38 -6.38 -0.33 5.98e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9560113 1.000 rs4773386 chr13:112180896 C/G cg14154082 chr13:112174009 NA 0.37 7.7 0.39 1.6e-13 Menarche (age at onset); LUSC cis rs11785400 0.793 rs13255558 chr8:143748080 C/T cg24634471 chr8:143751801 JRK 0.5 7.05 0.36 1.03e-11 Schizophrenia; LUSC cis rs8077889 0.719 rs2079006 chr17:41865745 C/G cg26893861 chr17:41843967 DUSP3 1.1 22.46 0.78 9.56e-69 Triglycerides; LUSC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg13393036 chr8:95962371 TP53INP1 -0.43 -9.37 -0.46 1.14e-18 Type 2 diabetes; LUSC cis rs34734847 1.000 rs3021338 chr12:121162989 A/G cg27246729 chr12:121163418 ACADS 0.47 7.5 0.38 5.91e-13 Mean corpuscular volume; LUSC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg13531842 chr10:38383804 ZNF37A -0.45 -6.98 -0.36 1.57e-11 Extrinsic epigenetic age acceleration; LUSC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg15556689 chr8:8085844 FLJ10661 -0.67 -10.78 -0.51 1.94e-23 Mood instability; LUSC cis rs738321 0.658 rs5756916 chr22:38507047 G/A cg25457927 chr22:38595422 NA -0.34 -6.31 -0.33 8.63e-10 Breast cancer; LUSC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg20818283 chr2:191399100 TMEM194B 0.44 6.78 0.35 5.56e-11 Pulse pressure; LUSC cis rs1577917 0.916 rs4706252 chr6:86555180 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.69 -0.34 9.59e-11 Response to antipsychotic treatment; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10190329 chr10:126605450 NA -0.34 -6.03 -0.31 4.37e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs16976116 0.901 rs62020097 chr15:55491007 A/T cg11288833 chr15:55489084 RSL24D1 0.5 5.98 0.31 5.65e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs561341 1.000 rs55643307 chr17:30263074 T/C cg27661571 chr11:113659931 NA -0.73 -7.95 -0.4 2.97e-14 Hip circumference adjusted for BMI; LUSC trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs12410462 0.581 rs111356515 chr1:227537236 C/G cg04117972 chr1:227635322 NA 0.62 6.98 0.36 1.55e-11 Major depressive disorder; LUSC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg08493051 chr2:3487164 NA -0.53 -8.21 -0.41 4.82e-15 Neurofibrillary tangles; LUSC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg23172400 chr8:95962367 TP53INP1 -0.3 -5.8 -0.3 1.51e-8 Type 2 diabetes; LUSC cis rs6582630 0.599 rs8175936 chr12:38426315 C/G cg13010199 chr12:38710504 ALG10B -0.44 -6.57 -0.34 1.95e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg26924012 chr15:45694286 SPATA5L1 1.14 20.79 0.75 3.36e-62 Homoarginine levels; LUSC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg23711669 chr6:146136114 FBXO30 0.69 10.41 0.5 3.55e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs10740039 0.883 rs7068934 chr10:62396248 C/T cg18175470 chr10:62150864 ANK3 -0.46 -6.9 -0.35 2.64e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg18301423 chr5:131593218 PDLIM4 0.35 5.75 0.3 2.06e-8 Blood metabolite levels; LUSC cis rs11864453 0.647 rs10492813 chr16:72122463 A/G cg01557791 chr16:72042693 DHODH 0.46 6.98 0.36 1.55e-11 Fibrinogen levels; LUSC cis rs7107174 1.000 rs4945267 chr11:78037933 G/A cg02023728 chr11:77925099 USP35 0.47 6.76 0.35 6.01e-11 Testicular germ cell tumor; LUSC cis rs7605827 0.866 rs9287665 chr2:15667263 A/T cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.31e-17 Educational attainment (years of education); LUSC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg05025164 chr4:1340916 KIAA1530 0.53 8.41 0.42 1.17e-15 Longevity; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09260951 chr22:39096513 JOSD1 -0.5 -6.17 -0.32 1.95e-9 Bipolar disorder and schizophrenia; LUSC cis rs3087591 1.000 rs2057769 chr17:29691368 C/A cg24425628 chr17:29625626 OMG;NF1 -0.59 -8.31 -0.41 2.4e-15 Hip circumference; LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg23743428 chr13:21893420 NA -0.41 -8.55 -0.42 4.59e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg05552183 chr6:42928497 GNMT 0.47 7.81 0.39 7.71e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4851254 0.961 rs11682173 chr2:100759810 C/T cg07810366 chr2:100720526 AFF3 -0.36 -5.69 -0.3 2.82e-8 Intelligence (multi-trait analysis); LUSC trans rs208520 0.661 rs207079 chr6:66770462 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -17.07 -0.68 2.11e-47 Exhaled nitric oxide output; LUSC trans rs4295623 0.553 rs11250163 chr8:11596437 G/T cg06636001 chr8:8085503 FLJ10661 0.51 7.72 0.39 1.39e-13 Morning vs. evening chronotype; LUSC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg00945038 chr17:61921165 SMARCD2 0.39 5.65 0.3 3.42e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg00945038 chr17:61921165 SMARCD2 -0.56 -9.71 -0.47 8.42e-20 Prudent dietary pattern; LUSC cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg24642439 chr20:33292090 TP53INP2 0.52 7.98 0.4 2.36e-14 Coronary artery disease; LUSC cis rs500891 0.525 rs1937783 chr6:84097858 G/C cg08257003 chr6:84140564 ME1 0.35 8.51 0.42 5.77e-16 Platelet-derived growth factor BB levels; LUSC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.25 0.32 1.23e-9 Hip circumference adjusted for BMI; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg03461704 chr1:205818484 PM20D1 -0.37 -6.16 -0.32 2.09e-9 Menarche (age at onset); LUSC cis rs2806561 0.754 rs648322 chr1:23294839 C/T cg19743168 chr1:23544995 NA 0.4 8.63 0.43 2.51e-16 Height; LUSC trans rs6601327 0.602 rs7820917 chr8:9647868 C/T cg08975724 chr8:8085496 FLJ10661 0.47 6.79 0.35 5.23e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.66 0.3 3.2e-8 Menopause (age at onset); LUSC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg01065977 chr19:18549689 ISYNA1 -0.23 -5.95 -0.31 6.72e-9 Breast cancer; LUSC cis rs2798269 0.902 rs11616720 chr13:22115822 A/G cg18095732 chr13:22033692 ZDHHC20 -0.38 -5.75 -0.3 2.02e-8 PR segment; LUSC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg18402987 chr7:1209562 NA 0.67 7.08 0.36 8.56e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11155671 0.530 rs3823021 chr6:150210999 G/C cg13206674 chr6:150067644 NUP43 0.43 6.52 0.34 2.67e-10 Testicular germ cell tumor; LUSC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg09904177 chr6:26538194 HMGN4 0.49 7.72 0.39 1.4e-13 Schizophrenia; LUSC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg10523679 chr1:76189770 ACADM 0.85 11.36 0.53 1.72e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7605827 0.930 rs3805102 chr2:15518312 G/A cg19274914 chr2:15703543 NA 0.47 9.2 0.45 4.07e-18 Educational attainment (years of education); LUSC cis rs701145 0.585 rs6789213 chr3:153792795 T/C cg17054900 chr3:154042577 DHX36 0.72 7.3 0.37 2.17e-12 Coronary artery disease; LUSC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.46 7.89 0.4 4.26e-14 Breast cancer; LUSC cis rs9811920 0.893 rs720688 chr3:99880569 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.33 6.16 0.32 2.05e-9 Axial length; LUSC cis rs61931739 0.500 rs3924704 chr12:34557833 C/T cg06521331 chr12:34319734 NA -0.43 -6.69 -0.34 9.47e-11 Morning vs. evening chronotype; LUSC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs9359856 0.872 rs9344948 chr6:90308226 T/G cg13799429 chr6:90582589 CASP8AP2 0.55 6.41 0.33 5.1e-10 Bipolar disorder; LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.84 12.34 0.56 4.57e-29 Alzheimer's disease; LUSC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg21782813 chr7:2030301 MAD1L1 0.58 10.22 0.49 1.6e-21 Bipolar disorder and schizophrenia; LUSC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg01448562 chr3:133502909 NA 0.64 10.5 0.5 1.8e-22 Iron status biomarkers; LUSC cis rs2153904 0.793 rs12564209 chr1:205720212 C/G cg23034840 chr1:205782522 SLC41A1 -0.62 -6.51 -0.34 2.72e-10 Prostate-specific antigen levels; LUSC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg23630131 chr7:65973040 NA -0.2 -5.64 -0.3 3.55e-8 Aortic root size; LUSC cis rs7809950 0.798 rs2701684 chr7:107299527 C/T cg23024343 chr7:107201750 COG5 0.39 6.04 0.31 4.17e-9 Coronary artery disease; LUSC cis rs3820068 0.506 rs17448966 chr1:15990983 T/G cg17385448 chr1:15911702 AGMAT 0.34 5.95 0.31 6.92e-9 Systolic blood pressure; LUSC cis rs8072100 0.967 rs7221548 chr17:45582952 T/C cg08085267 chr17:45401833 C17orf57 0.53 8.6 0.43 3.14e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg00814883 chr7:100076585 TSC22D4 -0.73 -9.85 -0.47 2.85e-20 Platelet count; LUSC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg21535247 chr6:8435926 SLC35B3 0.58 9.13 0.45 6.72e-18 Motion sickness; LUSC cis rs61931739 1.000 rs61931739 chr12:34089973 C/T cg06521331 chr12:34319734 NA 0.4 6.5 0.34 2.87e-10 Morning vs. evening chronotype; LUSC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg13206674 chr6:150067644 NUP43 0.63 10.17 0.49 2.44e-21 Lung cancer; LUSC cis rs1577917 0.561 rs3087978 chr6:86388223 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 7.29 0.37 2.2e-12 Response to antipsychotic treatment; LUSC cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg13770153 chr20:60521292 NA -0.62 -8.46 -0.42 8.32e-16 Body mass index; LUSC trans rs61931739 0.500 rs4436630 chr12:34394200 C/T cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.35e-33 Morning vs. evening chronotype; LUSC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.46 9.05 0.44 1.21e-17 Monocyte percentage of white cells; LUSC trans rs2688325 0.520 rs10107710 chr8:3761737 C/T cg10396673 chr16:31104726 VKORC1 0.33 6.12 0.32 2.69e-9 Menarche (age at onset); LUSC cis rs7903847 0.642 rs11189179 chr10:99143320 T/C cg20016023 chr10:99160130 RRP12 -0.33 -8.07 -0.4 1.26e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs7119038 0.818 rs11217040 chr11:118680648 C/A cg19308663 chr11:118741387 NA 0.33 5.71 0.3 2.54e-8 Sjögren's syndrome; LUSC cis rs11112613 0.713 rs12296355 chr12:105953321 C/A cg03607813 chr12:105948248 NA 0.78 11.48 0.53 6.09e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg17845761 chr1:175162550 KIAA0040 0.31 5.94 0.31 7.14e-9 Diastolic blood pressure; LUSC cis rs1577917 0.958 rs13213551 chr6:86608701 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.26 -0.41 3.4e-15 Response to antipsychotic treatment; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg03188948 chr7:1209495 NA 0.44 6.83 0.35 3.93e-11 Longevity;Endometriosis; LUSC cis rs3782089 1.000 rs11600543 chr11:65298939 G/A cg21890820 chr11:65308645 LTBP3 1.41 9.74 0.47 7e-20 Height; LUSC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs9323205 0.765 rs2999388 chr14:51654157 A/G cg23942311 chr14:51606299 NA 0.32 6.66 0.34 1.13e-10 Cancer; LUSC trans rs6601327 0.575 rs7001832 chr8:9607235 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.24 -0.32 1.36e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg02423579 chr7:2872169 GNA12 -0.41 -6.17 -0.32 2e-9 Height; LUSC cis rs4654899 1.000 rs7554997 chr1:21400139 C/T cg01072550 chr1:21505969 NA -0.54 -8.15 -0.41 7.63e-15 Superior frontal gyrus grey matter volume; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg23034840 chr1:205782522 SLC41A1 -0.55 -7.79 -0.39 8.57e-14 Menarche (age at onset); LUSC cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg13010199 chr12:38710504 ALG10B 0.64 9.96 0.48 1.23e-20 Bladder cancer; LUSC cis rs6964587 1.000 rs12537846 chr7:91721581 C/T cg17063962 chr7:91808500 NA -0.59 -9.17 -0.45 4.97e-18 Breast cancer; LUSC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg06238570 chr21:40685208 BRWD1 -0.62 -10.65 -0.5 5.48e-23 Cognitive function; LUSC cis rs9311676 0.632 rs4228 chr3:58413669 G/T cg26110898 chr3:58419937 PDHB 0.4 6.48 0.33 3.3e-10 Systemic lupus erythematosus; LUSC cis rs3892630 0.824 rs12327732 chr19:33221767 C/T cg22980127 chr19:33182716 NUDT19 0.92 12.61 0.57 4.49e-30 Red blood cell traits; LUSC cis rs17270561 0.541 rs12192932 chr6:25911502 A/G cg17042849 chr6:26104293 HIST1H4C -0.57 -6.63 -0.34 1.36e-10 Iron status biomarkers; LUSC cis rs1983170 0.736 rs745731 chr1:92011467 G/T cg25838465 chr1:92012736 NA 0.46 5.73 0.3 2.2e-8 Eosinophil percentage of white cells; LUSC cis rs8078723 1.000 rs59925331 chr17:38169273 C/G cg17467752 chr17:38218738 THRA 0.77 12.44 0.56 1.94e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg09085632 chr11:111637200 PPP2R1B -1.05 -17.16 -0.68 8.97e-48 Primary sclerosing cholangitis; LUSC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg18230493 chr5:56204884 C5orf35 -0.97 -14.44 -0.62 4.51e-37 Initial pursuit acceleration; LUSC cis rs4664304 0.903 rs72957578 chr2:160754133 G/C cg23995753 chr2:160760732 LY75 -0.31 -5.75 -0.3 2.05e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2797160 1.000 rs1739374 chr6:126011825 C/T cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.94e-16 Endometrial cancer; LUSC cis rs3092073 0.669 rs11697323 chr20:44551579 C/T cg23303369 chr20:44641161 MMP9 0.35 6.11 0.32 2.77e-9 Intelligence (multi-trait analysis); LUSC cis rs17270561 0.609 rs1892254 chr6:25750530 T/C cg16482183 chr6:26056742 HIST1H1C 0.65 9.06 0.44 1.15e-17 Iron status biomarkers; LUSC cis rs5769765 0.955 rs2295406 chr22:50260169 G/A cg02269571 chr22:50332266 NA 0.59 8.73 0.43 1.21e-16 Schizophrenia; LUSC cis rs3818285 0.885 rs10787217 chr10:111621103 A/T cg00817464 chr10:111662876 XPNPEP1 0.57 7.52 0.38 5.04e-13 Superior crus of antihelix expression; LUSC trans rs8072100 0.840 rs12453233 chr17:45454570 C/T cg03886242 chr7:26192032 NFE2L3 -0.4 -6.48 -0.33 3.34e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7605827 0.836 rs9287662 chr2:15595994 A/G cg19274914 chr2:15703543 NA 0.47 9.02 0.44 1.51e-17 Educational attainment (years of education); LUSC cis rs11264799 0.581 rs2779158 chr1:157549170 A/T cg18268488 chr1:157545234 FCRL4 -0.36 -6.61 -0.34 1.55e-10 IgA nephropathy; LUSC cis rs67696533 0.600 rs12625036 chr20:31112689 G/A cg13636640 chr20:31349939 DNMT3B 0.49 6.66 0.34 1.13e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg22681709 chr2:178499509 PDE11A -0.51 -8.94 -0.44 2.66e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -13.92 -0.61 4.61e-35 Extrinsic epigenetic age acceleration; LUSC cis rs4499344 0.730 rs28416849 chr19:33099758 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs11122272 0.735 rs2250719 chr1:231486208 G/A cg06096015 chr1:231504339 EGLN1 0.55 9.66 0.47 1.23e-19 Hemoglobin concentration; LUSC cis rs7927771 0.524 rs7124396 chr11:47787434 T/G cg20307385 chr11:47447363 PSMC3 -0.44 -6.61 -0.34 1.51e-10 Subjective well-being; LUSC trans rs853679 0.546 rs200954 chr6:27838764 C/G cg01620082 chr3:125678407 NA -0.74 -7.22 -0.37 3.52e-12 Depression; LUSC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg11632617 chr15:75315747 PPCDC -0.52 -6.72 -0.35 7.64e-11 Blood trace element (Zn levels); LUSC cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg26384229 chr12:38710491 ALG10B 0.93 15.89 0.66 9.63e-43 Bladder cancer; LUSC cis rs2777491 0.574 rs2730056 chr15:41735785 A/G cg18705301 chr15:41695430 NDUFAF1 -1.01 -19.84 -0.74 2.06e-58 Ulcerative colitis; LUSC cis rs9811920 0.641 rs58704213 chr3:99690331 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.34 -6.46 -0.33 3.75e-10 Axial length; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19784910 chr11:101785671 KIAA1377;ANGPTL5 0.41 5.95 0.31 6.61e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg09491104 chr22:46646882 C22orf40 -0.65 -6.65 -0.34 1.22e-10 LDL cholesterol;Cholesterol, total; LUSC trans rs3774749 0.565 rs1005678 chr3:50210289 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.41 6.04 0.31 4.14e-9 Intelligence (multi-trait analysis); LUSC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg06108461 chr20:60628389 TAF4 -1.01 -17.18 -0.68 7.43e-48 Body mass index; LUSC cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg13256891 chr4:100009986 ADH5 -0.42 -5.78 -0.3 1.71e-8 Alcohol dependence; LUSC cis rs9929218 0.551 rs2274240 chr16:68725486 A/G cg01251360 chr16:68772225 CDH1 -0.27 -6.48 -0.33 3.23e-10 Colorectal cancer; LUSC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.36e-8 Lung cancer; LUSC cis rs9807841 0.592 rs7250071 chr19:10765819 A/G cg17710535 chr19:10819994 QTRT1 -0.38 -6.18 -0.32 1.86e-9 Inflammatory skin disease; LUSC cis rs427394 0.582 rs274667 chr5:6710771 A/G cg10857441 chr5:6722123 POLS 0.43 7.98 0.4 2.38e-14 Menopause (age at onset); LUSC cis rs7100689 0.646 rs7077854 chr10:82124070 C/T cg00277334 chr10:82204260 NA -0.52 -7.79 -0.39 8.72e-14 Post bronchodilator FEV1; LUSC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 10.15 0.49 2.9e-21 Hip circumference adjusted for BMI; LUSC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.93 -0.31 7.38e-9 Lung cancer; LUSC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg14780466 chr2:20870812 GDF7 -0.39 -7.86 -0.4 5.32e-14 Abdominal aortic aneurysm; LUSC cis rs4363385 0.782 rs1933381 chr1:153003255 C/G cg25856811 chr1:152973957 SPRR3 -0.35 -5.8 -0.3 1.52e-8 Inflammatory skin disease; LUSC cis rs2295359 0.892 rs12029362 chr1:67624231 G/A cg17031739 chr1:67600172 NA 0.46 7.08 0.36 8.8e-12 Psoriasis; LUSC cis rs500891 0.570 rs13219666 chr6:83916069 A/G cg08257003 chr6:84140564 ME1 0.25 5.69 0.3 2.75e-8 Platelet-derived growth factor BB levels; LUSC cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg00071950 chr4:10020882 SLC2A9 -0.52 -8.85 -0.44 5.12e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg06671706 chr8:8559999 CLDN23 0.48 6.52 0.34 2.59e-10 Obesity-related traits; LUSC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.43 -0.73 8.64e-57 Height; LUSC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg08888203 chr3:10149979 C3orf24 -0.53 -7.03 -0.36 1.18e-11 Alzheimer's disease; LUSC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg00745463 chr17:30367425 LRRC37B -0.8 -9.28 -0.45 2.13e-18 Hip circumference adjusted for BMI; LUSC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg26566898 chr11:117069891 TAGLN 0.46 8.08 0.4 1.24e-14 Blood protein levels; LUSC trans rs61931739 0.513 rs1486889 chr12:33901229 A/G cg13010199 chr12:38710504 ALG10B 0.49 7.64 0.39 2.32e-13 Morning vs. evening chronotype; LUSC cis rs1355223 1.000 rs1396883 chr11:34757447 C/T cg11058730 chr11:34937778 PDHX;APIP -0.4 -5.79 -0.3 1.63e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9323205 1.000 rs9323205 chr14:51586467 A/G cg23942311 chr14:51606299 NA -0.43 -8.27 -0.41 3.27e-15 Cancer; LUSC cis rs1775715 0.678 rs7096139 chr10:32217404 A/C cg04359828 chr10:32216031 ARHGAP12 0.39 6.63 0.34 1.36e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs7666738 0.546 rs13148080 chr4:98680947 A/G cg05340658 chr4:99064831 C4orf37 0.59 8.88 0.44 4.12e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs8070128 0.601 rs8080602 chr17:17954728 G/C cg16928487 chr17:17741425 SREBF1 0.37 7.13 0.36 6.28e-12 Total body bone mineral density; LUSC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.58 0.34 1.83e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs7824557 0.564 rs7839307 chr8:11198792 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.64 0.34 1.28e-10 Retinal vascular caliber; LUSC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg08219700 chr8:58056026 NA 0.5 6.4 0.33 5.22e-10 Developmental language disorder (linguistic errors); LUSC trans rs9329221 0.736 rs34381075 chr8:10243785 C/G cg06636001 chr8:8085503 FLJ10661 0.56 7.8 0.39 8.01e-14 Neuroticism; LUSC cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg15423357 chr2:25149977 NA -0.42 -8.44 -0.42 1.01e-15 Body mass index; LUSC cis rs9815354 0.767 rs6805140 chr3:41995791 A/G cg03022575 chr3:42003672 ULK4 0.82 8.59 0.43 3.29e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs1728785 1.000 rs1728785 chr16:68591230 G/T cg02972257 chr16:68554789 NA 0.52 6.73 0.35 7.2e-11 Ulcerative colitis; LUSC cis rs11252926 0.545 rs1551508 chr10:555469 A/G cg03684893 chr10:554711 DIP2C -0.45 -8.55 -0.42 4.64e-16 Psychosis in Alzheimer's disease; LUSC cis rs983392 0.868 rs11605427 chr11:59928672 G/C cg20284999 chr11:59952153 MS4A6A -0.35 -5.65 -0.3 3.46e-8 Alzheimer's disease (late onset); LUSC cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg12935359 chr14:103987150 CKB -0.49 -7.75 -0.39 1.1e-13 Body mass index; LUSC cis rs35883536 0.647 rs2809790 chr1:101040461 C/T cg06223162 chr1:101003688 GPR88 0.49 9.35 0.46 1.26e-18 Monocyte count; LUSC cis rs35146811 0.660 rs3779045 chr7:99779259 T/C cg13334819 chr7:99746414 C7orf59 -0.5 -6.67 -0.34 1.05e-10 Coronary artery disease; LUSC cis rs2377585 0.653 rs10770955 chr12:8842752 C/T cg03761649 chr12:8850719 RIMKLB 0.48 6.25 0.32 1.26e-9 Reticulocyte fraction of red cells; LUSC cis rs887829 0.570 rs4261716 chr2:234593117 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -6.16 -0.32 2.13e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs314370 0.951 rs13226502 chr7:100506381 C/T cg08558340 chr7:100472263 SRRT 0.5 6.23 0.32 1.39e-9 Resting heart rate; LUSC trans rs683250 0.965 rs684857 chr11:83308002 A/G cg26617787 chr11:123396133 GRAMD1B 0.32 6.12 0.32 2.67e-9 Subcortical brain region volumes; LUSC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg25287198 chr4:183728479 NA 0.57 7.59 0.38 3.3e-13 Pediatric autoimmune diseases; LUSC cis rs9462027 0.628 rs9689820 chr6:34752963 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.11e-8 Systemic lupus erythematosus; LUSC cis rs11971779 0.680 rs1986447 chr7:139082080 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.81 13.1 0.58 6.19e-32 Hip circumference adjusted for BMI; LUSC cis rs6545977 1.000 rs6545977 chr2:63301164 G/A cg17519650 chr2:63277830 OTX1 -0.79 -12.94 -0.58 2.49e-31 Prostate cancer; LUSC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg02187348 chr16:89574699 SPG7 0.63 10.33 0.49 7.02e-22 Multiple myeloma (IgH translocation); LUSC trans rs28735056 0.592 rs12455965 chr18:77688830 G/C cg05926928 chr17:57297772 GDPD1 -0.47 -6.54 -0.34 2.33e-10 Schizophrenia; LUSC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg02951883 chr7:2050386 MAD1L1 -0.35 -5.9 -0.31 8.75e-9 Bipolar disorder and schizophrenia; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg01171360 chr6:293285 DUSP22 -0.68 -11.24 -0.52 4.33e-25 Menopause (age at onset); LUSC cis rs763014 0.966 rs35642938 chr16:642249 T/C cg00908189 chr16:619842 PIGQ 0.71 11.15 0.52 9.52e-25 Height; LUSC cis rs7561273 0.586 rs11900665 chr2:24298198 T/C cg20701182 chr2:24300061 SF3B14 0.45 5.77 0.3 1.78e-8 Quantitative traits; LUSC cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg06640241 chr16:89574553 SPG7 -0.62 -9.12 -0.45 7.21e-18 Multiple myeloma (IgH translocation); LUSC cis rs11105298 0.891 rs10858894 chr12:89914261 T/C cg00757033 chr12:89920650 WDR51B 0.59 10.28 0.49 1.03e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 12.46 0.56 1.65e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg04414720 chr1:150670196 GOLPH3L -0.44 -7.03 -0.36 1.18e-11 Tonsillectomy; LUSC cis rs2730245 0.618 rs859781 chr7:158661758 G/A cg01943577 chr7:158741284 NA -0.39 -5.73 -0.3 2.29e-8 Height; LUSC cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg18758796 chr5:131593413 PDLIM4 0.34 5.91 0.31 8.44e-9 Blood metabolite levels; LUSC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg04553112 chr3:125709451 NA -0.51 -5.75 -0.3 2.06e-8 Blood pressure (smoking interaction); LUSC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg08280861 chr8:58055591 NA 0.54 5.89 0.31 9.6e-9 Developmental language disorder (linguistic errors); LUSC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg19901468 chr14:105411992 AHNAK2 -0.71 -12.67 -0.57 2.53e-30 Rheumatoid arthritis; LUSC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg06718696 chr17:78121285 EIF4A3 0.79 11.72 0.54 8.6e-27 Plateletcrit;Mean corpuscular hemoglobin concentration; LUSC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03264133 chr6:25882463 NA -0.48 -8.1 -0.41 1.04e-14 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.863 rs1480939 chr4:120456927 T/C cg24375607 chr4:120327624 NA 0.77 11.32 0.53 2.32e-25 Corneal astigmatism; LUSC cis rs1728785 1.000 rs3203684 chr16:68600440 C/T cg02972257 chr16:68554789 NA 0.51 6.54 0.34 2.27e-10 Ulcerative colitis; LUSC cis rs6681460 0.901 rs1570815 chr1:67139667 C/T cg02459107 chr1:67143332 SGIP1 0.49 9.13 0.45 6.62e-18 Presence of antiphospholipid antibodies; LUSC cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg15839431 chr19:19639596 YJEFN3 -0.59 -6.31 -0.33 8.91e-10 Bipolar disorder; LUSC trans rs6502050 0.731 rs76421195 chr17:80109326 T/C cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg24838063 chr12:130822603 PIWIL1 0.71 10.99 0.52 3.57e-24 Menopause (age at onset); LUSC trans rs6598955 0.671 rs6681452 chr1:26621101 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.67 -9.33 -0.45 1.55e-18 Obesity-related traits; LUSC cis rs8018808 0.935 rs11159262 chr14:77928735 A/G cg20045696 chr14:77926864 AHSA1 0.34 5.76 0.3 1.95e-8 Myeloid white cell count; LUSC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg20243544 chr17:37824526 PNMT 0.48 6.84 0.35 3.81e-11 Asthma; LUSC cis rs35123781 1.000 rs601728 chr5:139057076 T/C cg10513866 chr5:139070639 NA 0.46 8.9 0.44 3.62e-17 Schizophrenia; LUSC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.46 7.5 0.38 5.89e-13 Intelligence (multi-trait analysis); LUSC cis rs7267979 0.966 rs2261747 chr20:25261784 G/A cg08601574 chr20:25228251 PYGB 0.45 6.9 0.35 2.69e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs231513 0.911 rs231521 chr17:41955158 A/G cg26893861 chr17:41843967 DUSP3 -0.54 -5.96 -0.31 6.54e-9 Cognitive function; LUSC cis rs1595825 0.891 rs16826873 chr2:198898222 A/C cg10547527 chr2:198650123 BOLL 0.51 6.18 0.32 1.85e-9 Ulcerative colitis; LUSC cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg08213375 chr14:104286397 PPP1R13B 0.54 10.89 0.51 7.59e-24 Schizophrenia; LUSC cis rs10876993 0.928 rs2928053 chr12:58063475 T/C cg18357645 chr12:58087776 OS9 0.57 8.64 0.43 2.29e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg06212747 chr3:49208901 KLHDC8B 0.45 5.87 0.31 1.06e-8 Parkinson's disease; LUSC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg21028142 chr17:79581711 NPLOC4 0.32 7.68 0.39 1.78e-13 Eye color traits; LUSC cis rs6912958 0.500 rs4706287 chr6:87806496 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.44 -8.08 -0.4 1.17e-14 Monocyte percentage of white cells; LUSC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -8.55 -0.42 4.64e-16 Hemoglobin concentration; LUSC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.71 0.43 1.4e-16 Axial length; LUSC cis rs79839061 0.656 rs11726508 chr4:888937 C/T cg07828340 chr4:882639 GAK 0.86 9.99 0.48 9.49e-21 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg16325326 chr1:53192061 ZYG11B -0.89 -16.56 -0.67 2.25e-45 Monocyte count; LUSC cis rs2307022 0.586 rs4783623 chr16:68390113 A/G cg02226672 chr16:68398533 SMPD3 0.3 5.68 0.3 2.93e-8 Body mass index; LUSC cis rs7582180 0.607 rs1530029 chr2:100968205 C/T cg08017756 chr2:100939284 LONRF2 -0.49 -9.18 -0.45 4.73e-18 Intelligence (multi-trait analysis); LUSC cis rs1461503 0.512 rs4259833 chr11:122809205 G/A cg27398637 chr11:122830231 C11orf63 -0.39 -6.28 -0.32 1.07e-9 Menarche (age at onset); LUSC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs362296 0.698 rs362282 chr4:3259671 G/A cg14583973 chr4:3374767 RGS12 -0.31 -5.9 -0.31 8.95e-9 Parental longevity (mother's age at death); LUSC cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg08999081 chr20:33150536 PIGU 0.44 8.14 0.41 8e-15 Coronary artery disease; LUSC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg08684580 chr7:98029266 BAIAP2L1 0.4 7.37 0.37 1.32e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs5769707 0.681 rs9616329 chr22:50026314 G/A cg07959070 chr22:50026188 C22orf34 -0.33 -6.24 -0.32 1.35e-9 Monocyte count;Monocyte percentage of white cells; LUSC trans rs2797160 1.000 rs2747724 chr6:126004935 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.66 -0.34 1.16e-10 Endometrial cancer; LUSC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.77 -0.8 1.22e-77 Height; LUSC cis rs8060686 0.623 rs28700885 chr16:68154544 A/G cg05110241 chr16:68378359 PRMT7 -0.45 -5.94 -0.31 7.27e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs9790314 1.000 rs336589 chr3:161080358 C/T cg03342759 chr3:160939853 NMD3 -0.48 -8.21 -0.41 4.92e-15 Morning vs. evening chronotype; LUSC trans rs61931739 0.513 rs1608908 chr12:33895389 C/A cg13010199 chr12:38710504 ALG10B 0.48 7.56 0.38 3.82e-13 Morning vs. evening chronotype; LUSC cis rs5167 0.566 rs60876330 chr19:45488133 C/T cg13119609 chr19:45449297 APOC2 0.34 5.67 0.3 3.01e-8 Blood protein levels; LUSC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg13535736 chr9:111863775 C9orf5 0.4 6.73 0.35 7.24e-11 Menarche (age at onset); LUSC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg06028605 chr16:24865363 SLC5A11 0.51 9.08 0.44 9.73e-18 Intelligence (multi-trait analysis); LUSC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg11871910 chr12:69753446 YEATS4 0.68 10.44 0.5 2.95e-22 Blood protein levels; LUSC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg21770322 chr7:97807741 LMTK2 0.42 7.23 0.37 3.25e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs12493885 0.769 rs11718319 chr3:153776944 G/A cg17054900 chr3:154042577 DHX36 -0.72 -7.06 -0.36 9.58e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs17401966 0.537 rs3748575 chr1:10342352 C/T cg17425144 chr1:10567563 PEX14 -0.34 -6.19 -0.32 1.72e-9 Hepatocellular carcinoma; LUSC cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg05043794 chr9:111880884 C9orf5 -0.37 -7.81 -0.39 7.29e-14 Menarche (age at onset); LUSC cis rs2274273 0.840 rs10136596 chr14:55836773 A/G cg04306507 chr14:55594613 LGALS3 0.54 11.8 0.54 4.11e-27 Protein biomarker; LUSC cis rs4631830 1.000 rs4631830 chr10:51543344 C/T cg10326726 chr10:51549505 MSMB -0.34 -5.69 -0.3 2.81e-8 Prostate-specific antigen levels; LUSC cis rs877282 0.755 rs2486578 chr10:785227 C/T cg17470449 chr10:769945 NA -0.4 -6.04 -0.31 4.1e-9 Uric acid levels; LUSC cis rs7188861 0.768 rs1646025 chr16:11379938 A/G cg00044050 chr16:11439710 C16orf75 0.54 6.16 0.32 2.14e-9 HDL cholesterol; LUSC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 -0.68 -8.53 -0.42 5.08e-16 Lung function (FEV1/FVC); LUSC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg09267113 chr7:98030324 BAIAP2L1 0.4 6.05 0.31 3.79e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg07414643 chr4:187882934 NA -0.56 -10.2 -0.49 1.98e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs11190604 1.000 rs11190599 chr10:102295420 C/T cg23241863 chr10:102295624 HIF1AN 0.48 5.91 0.31 8.26e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11155671 0.530 rs9397420 chr6:150206781 C/T cg09699651 chr6:150184138 LRP11 -0.43 -6.88 -0.35 2.93e-11 Testicular germ cell tumor; LUSC cis rs6912958 0.712 rs6454640 chr6:88370352 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.06 0.44 1.14e-17 Monocyte percentage of white cells; LUSC trans rs656319 0.580 rs13252589 chr8:10005526 A/G cg15556689 chr8:8085844 FLJ10661 -0.56 -8.16 -0.41 6.76e-15 Myopia (pathological); LUSC cis rs3020736 0.500 rs1801311 chr22:42486723 G/A cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs2742417 0.603 rs2673032 chr3:45756927 C/T cg04837898 chr3:45731254 SACM1L -0.43 -7.01 -0.36 1.34e-11 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg03146154 chr1:46216737 IPP 0.56 8.36 0.42 1.77e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7180079 1.000 rs7175456 chr15:64534620 C/G cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs2777491 0.915 rs7178634 chr15:41634587 A/G cg18705301 chr15:41695430 NDUFAF1 -0.76 -14.42 -0.62 5.41e-37 Ulcerative colitis; LUSC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg07636037 chr3:49044803 WDR6 0.45 6.44 0.33 4.27e-10 Resting heart rate; LUSC cis rs892961 0.899 rs312911 chr17:75414585 A/C cg05865280 chr17:75406074 SEPT9 0.48 10.33 0.49 7e-22 Airflow obstruction; LUSC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.51 8.94 0.44 2.77e-17 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19208331 chr3:37035345 MLH1;EPM2AIP1 -0.43 -6.32 -0.33 8.23e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2427308 0.607 rs1741635 chr20:60938197 C/G cg09594475 chr20:60884601 LAMA5 -0.44 -5.69 -0.3 2.79e-8 Colorectal cancer; LUSC cis rs16854884 0.586 rs4561830 chr3:143735572 C/T cg06585982 chr3:143692056 C3orf58 0.54 8.66 0.43 2.12e-16 Economic and political preferences (feminism/equality); LUSC cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg23583168 chr7:148888333 NA -0.9 -16.62 -0.67 1.27e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg16339924 chr4:17578868 LAP3 0.55 8.43 0.42 1.04e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2070433 0.556 rs8129460 chr21:47822544 C/T cg05998816 chr21:47859926 PCNT 0.37 5.67 0.3 3.12e-8 Lymphocyte counts; LUSC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.57 -7.8 -0.39 8.24e-14 Body mass index (adult); LUSC cis rs3770081 0.793 rs75675321 chr2:86238994 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.09 -6.81 -0.35 4.43e-11 Facial emotion recognition (sad faces); LUSC cis rs7474896 0.583 rs11011346 chr10:38009483 C/T cg25427524 chr10:38739819 LOC399744 -0.5 -6.3 -0.33 9.41e-10 Obesity (extreme); LUSC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg21984481 chr17:79567631 NPLOC4 -0.67 -13.81 -0.6 1.19e-34 Eye color traits; LUSC cis rs9457247 1.000 rs422094 chr6:167397033 C/G cg07741184 chr6:167504864 NA 0.36 6.51 0.34 2.84e-10 Crohn's disease; LUSC cis rs1395 0.744 rs1122227 chr2:27544285 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.46 6.7 0.34 8.69e-11 Blood metabolite levels; LUSC cis rs12421382 0.507 rs10890995 chr11:109327622 A/G cg11473876 chr11:109292803 C11orf87 -0.42 -6.61 -0.34 1.5e-10 Schizophrenia; LUSC cis rs6845621 0.745 rs2048962 chr4:18862059 T/A cg12196642 chr4:18937545 NA -0.31 -5.84 -0.3 1.23e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC trans rs1728785 1.000 rs889561 chr16:68605741 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.5 0.42 6.47e-16 Ulcerative colitis; LUSC cis rs1979679 0.608 rs1355472 chr12:28721414 C/T cg13890972 chr12:28721907 NA 0.39 5.67 0.3 3.17e-8 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg14530993 chr4:882597 GAK 0.72 7.41 0.38 1.07e-12 Intelligence (multi-trait analysis); LUSC cis rs7824557 0.670 rs2736381 chr8:11132766 A/T cg21775007 chr8:11205619 TDH -0.61 -9.26 -0.45 2.55e-18 Retinal vascular caliber; LUSC cis rs6696846 0.765 rs61822619 chr1:205090885 C/G cg21643547 chr1:205240462 TMCC2 -0.41 -7.55 -0.38 4.08e-13 Red blood cell count; LUSC cis rs2739330 0.652 rs2000469 chr22:24245292 A/G cg04234412 chr22:24373322 LOC391322 -0.79 -11.71 -0.54 8.94e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg00509249 chr6:109615579 CCDC162 -0.34 -6.12 -0.32 2.6e-9 Reticulocyte fraction of red cells; LUSC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg13683864 chr3:40499215 RPL14 0.99 17.72 0.7 5.34e-50 Renal cell carcinoma; LUSC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg22857025 chr5:266934 NA -1.17 -16.86 -0.68 1.46e-46 Breast cancer; LUSC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg22823121 chr1:150693482 HORMAD1 0.59 9.05 0.44 1.17e-17 Tonsillectomy; LUSC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03301945 chr19:10764555 ILF3;LOC147727 -0.42 -6.33 -0.33 7.85e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg15839431 chr19:19639596 YJEFN3 -0.58 -6.27 -0.32 1.12e-9 Bipolar disorder; LUSC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg13395646 chr4:1353034 KIAA1530 -0.57 -8.62 -0.43 2.81e-16 Obesity-related traits; LUSC cis rs7043114 0.525 rs7850432 chr9:95130510 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -6.84 -0.35 3.71e-11 Height; LUSC cis rs11030122 0.702 rs1349583 chr11:3972236 G/A cg18678763 chr11:4115507 RRM1 -0.47 -6.15 -0.32 2.26e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs4917385 1 rs4917385 chr10:105003721 T/G cg04362960 chr10:104952993 NT5C2 0.53 7.06 0.36 9.48e-12 Systemic lupus erythematosus; LUSC cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs4268898 0.686 rs2042468 chr2:24398446 A/T cg06627628 chr2:24431161 ITSN2 0.54 7.44 0.38 8.49e-13 Asthma; LUSC cis rs754466 0.580 rs1054608 chr10:79543308 T/G cg17075019 chr10:79541650 NA -0.77 -12.31 -0.56 5.8e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10761482 0.639 rs2067612 chr10:62212334 T/C cg18175470 chr10:62150864 ANK3 -0.52 -7.25 -0.37 3e-12 Schizophrenia; LUSC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.89 0.51 7.96e-24 Hip circumference adjusted for BMI; LUSC cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg06064525 chr11:970664 AP2A2 -0.49 -10.93 -0.51 5.8e-24 Alzheimer's disease (late onset); LUSC cis rs2274273 0.773 rs28430823 chr14:55816560 C/G cg04306507 chr14:55594613 LGALS3 0.53 11.62 0.54 1.95e-26 Protein biomarker; LUSC cis rs9399135 0.933 rs9389262 chr6:135376409 G/T cg22676075 chr6:135203613 NA 0.46 7.09 0.36 7.84e-12 Red blood cell count; LUSC cis rs2274273 0.837 rs6573010 chr14:55721592 T/C cg04306507 chr14:55594613 LGALS3 0.58 13.54 0.6 1.33e-33 Protein biomarker; LUSC cis rs2732480 0.557 rs923397 chr12:48720392 G/A cg04545296 chr12:48745243 ZNF641 0.34 6.26 0.32 1.2e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs7937682 0.924 rs11213968 chr11:111527629 G/C cg22437258 chr11:111473054 SIK2 0.5 6.78 0.35 5.6e-11 Primary sclerosing cholangitis; LUSC cis rs6725041 0.547 rs4672645 chr2:213204955 C/T cg16329650 chr2:213403929 ERBB4 -0.41 -6.58 -0.34 1.77e-10 QT interval (ambient particulate matter interaction); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg15190599 chr6:26156487 HIST1H1E -0.36 -6.1 -0.32 2.98e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7178572 0.568 rs4886850 chr15:77404160 G/C cg22256960 chr15:77711686 NA -0.51 -8.1 -0.41 1.07e-14 Type 2 diabetes; LUSC cis rs2219968 0.756 rs10504661 chr8:78846469 T/G cg00738934 chr8:78996279 NA -0.36 -6.13 -0.32 2.55e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9300255 0.679 rs10772998 chr12:123721177 T/G cg05973401 chr12:123451056 ABCB9 0.52 6.53 0.34 2.39e-10 Neutrophil percentage of white cells; LUSC cis rs1538970 0.781 rs34768551 chr1:46020408 G/A cg05343316 chr1:45956843 TESK2 0.7 9.29 0.45 2e-18 Platelet count; LUSC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg22823121 chr1:150693482 HORMAD1 0.58 8.88 0.44 4.07e-17 Tonsillectomy; LUSC cis rs7705502 0.962 rs72812861 chr5:173387509 T/C cg18693985 chr5:173351052 CPEB4 -0.4 -6.28 -0.33 1.04e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs11098499 0.909 rs35111518 chr4:120440682 A/G cg24375607 chr4:120327624 NA 0.76 11.01 0.52 2.89e-24 Corneal astigmatism; LUSC cis rs6906287 0.625 rs7453914 chr6:118692981 A/T cg05564266 chr6:118973597 C6orf204 0.25 6.08 0.32 3.36e-9 Electrocardiographic conduction measures; LUSC trans rs10506458 1.000 rs10506458 chr12:63445092 G/A cg22491629 chr6:157744540 C6orf35 -0.9 -10.67 -0.5 4.68e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs9300255 0.544 rs10772995 chr12:123671761 T/C cg00376283 chr12:123451042 ABCB9 0.66 8.31 0.41 2.45e-15 Neutrophil percentage of white cells; LUSC cis rs5770917 1.000 rs1557503 chr22:51013072 G/A cg24363820 chr22:51016703 CPT1B;CHKB-CPT1B -0.59 -5.73 -0.3 2.3e-8 Narcolepsy; LUSC cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.61 -7.7 -0.39 1.58e-13 Birth weight; LUSC cis rs4851254 0.660 rs4851244 chr2:100671449 C/T cg22139774 chr2:100720529 AFF3 0.43 5.9 0.31 9.03e-9 Intelligence (multi-trait analysis); LUSC cis rs7954584 0.567 rs11043233 chr12:122330733 C/T cg01765077 chr12:122356316 WDR66 0.54 7.76 0.39 1.07e-13 Mean corpuscular volume; LUSC cis rs66887589 0.616 rs6843509 chr4:120220196 G/A cg09307838 chr4:120376055 NA 0.52 7.79 0.39 8.65e-14 Diastolic blood pressure; LUSC cis rs11098499 0.754 rs10212775 chr4:120239244 G/C cg09307838 chr4:120376055 NA 0.7 10.54 0.5 1.25e-22 Corneal astigmatism; LUSC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg02269571 chr22:50332266 NA 0.58 8.57 0.42 3.99e-16 Schizophrenia; LUSC cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs929354 1.000 rs1182414 chr7:157058363 G/A cg05182265 chr7:156933206 UBE3C 0.45 6.85 0.35 3.46e-11 Body mass index; LUSC cis rs2274273 0.743 rs7161656 chr14:55524530 A/G cg04306507 chr14:55594613 LGALS3 0.49 10.72 0.51 3.06e-23 Protein biomarker; LUSC cis rs8114671 0.562 rs959829 chr20:33346047 T/C cg08999081 chr20:33150536 PIGU -0.33 -5.83 -0.3 1.31e-8 Height; LUSC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg19318889 chr4:1322082 MAEA 0.58 9.99 0.48 9.57e-21 Longevity; LUSC cis rs9815354 1.000 rs12639255 chr3:41861738 T/C cg03022575 chr3:42003672 ULK4 0.59 6.57 0.34 1.93e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg00376283 chr12:123451042 ABCB9 0.68 8.6 0.43 3.1e-16 Neutrophil percentage of white cells; LUSC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg09021430 chr5:549028 NA -0.55 -7.24 -0.37 3.12e-12 Lung disease severity in cystic fibrosis; LUSC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.16 -0.32 2.04e-9 Alzheimer's disease (late onset); LUSC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg22467129 chr15:76604101 ETFA -0.44 -7.08 -0.36 8.5e-12 Blood metabolite levels; LUSC cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg13770153 chr20:60521292 NA -0.61 -8.39 -0.42 1.43e-15 Body mass index; LUSC cis rs12681288 0.550 rs60530879 chr8:958381 G/C cg04851639 chr8:1020857 NA -0.35 -7.03 -0.36 1.19e-11 Schizophrenia; LUSC cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.12 -0.45 7.26e-18 Monocyte percentage of white cells; LUSC cis rs2479724 0.572 rs6920885 chr6:41941169 T/C cg17623882 chr6:41773611 USP49 -0.46 -7.71 -0.39 1.5e-13 Menarche (age at onset); LUSC cis rs6537837 0.701 rs12021920 chr1:110147287 C/T cg05049280 chr1:110155535 GNAT2 0.57 7.33 0.37 1.72e-12 Major depressive disorder; LUSC trans rs6582630 0.519 rs8189609 chr12:38281408 A/G cg06521331 chr12:34319734 NA -0.39 -5.99 -0.31 5.58e-9 Drug-induced liver injury (flucloxacillin); LUSC trans rs931812 0.895 rs4734493 chr8:101902169 C/T cg20993868 chr7:22813445 NA -0.63 -11.4 -0.53 1.17e-25 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs2439831 0.717 rs7165471 chr15:43644788 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.32 0.45 1.64e-18 Lung cancer in ever smokers; LUSC cis rs9650657 0.644 rs4395858 chr8:10521021 C/T cg27411982 chr8:10470053 RP1L1 0.45 7.04 0.36 1.08e-11 Neuroticism; LUSC cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.68 -0.43 1.81e-16 Body mass index; LUSC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.33 -0.49 7.03e-22 Alzheimer's disease; LUSC cis rs2455601 0.574 rs2568094 chr11:8992218 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -6.73 -0.35 7.35e-11 Schizophrenia; LUSC cis rs3087591 0.708 rs964288 chr17:29679246 G/A cg24425628 chr17:29625626 OMG;NF1 0.47 7.04 0.36 1.09e-11 Hip circumference; LUSC cis rs2425143 1.000 rs113203744 chr20:34253656 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -6.56 -0.34 2.09e-10 Blood protein levels; LUSC cis rs25645 0.823 rs12453334 chr17:38153473 C/T cg17467752 chr17:38218738 THRA -0.55 -7.66 -0.39 1.98e-13 Myeloid white cell count; LUSC cis rs12458462 0.851 rs3859317 chr18:77443093 A/C cg20476159 chr18:77451067 CTDP1 -0.32 -5.8 -0.3 1.58e-8 Monocyte count; LUSC cis rs9926296 0.656 rs4522419 chr16:89853307 T/C cg01097406 chr16:89675127 NA -0.37 -6.95 -0.36 1.95e-11 Vitiligo; LUSC cis rs6840360 0.615 rs4696094 chr4:152465501 C/T cg22705602 chr4:152727874 NA -0.32 -6.34 -0.33 7.55e-10 Intelligence (multi-trait analysis); LUSC cis rs7212938 0.509 rs62068170 chr17:38103210 G/A cg26162295 chr17:38119207 GSDMA -0.29 -6.96 -0.36 1.85e-11 Asthma and hay fever; LUSC cis rs950027 0.787 rs1547487 chr15:45723983 A/G cg26924012 chr15:45694286 SPATA5L1 0.71 10.73 0.51 2.94e-23 Response to fenofibrate (adiponectin levels); LUSC cis rs2273669 0.667 rs12215614 chr6:109313629 T/C cg05315195 chr6:109294784 ARMC2 -0.53 -5.96 -0.31 6.41e-9 Prostate cancer; LUSC cis rs2806561 0.765 rs1738469 chr1:23511407 G/C cg19743168 chr1:23544995 NA 0.41 7.91 0.4 3.79e-14 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13453053 chr17:26662113 TNFAIP1;IFT20 0.66 6.18 0.32 1.9e-9 Cognitive performance; LUSC cis rs7089973 0.604 rs11196937 chr10:116589500 G/C cg03647239 chr10:116582469 FAM160B1 0.45 7.27 0.37 2.55e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg22484793 chr3:52261325 TLR9 0.27 6.15 0.32 2.21e-9 Electroencephalogram traits; LUSC cis rs67311347 0.955 rs2123999 chr3:40378738 C/T cg17264618 chr3:40429014 ENTPD3 0.31 6.9 0.35 2.65e-11 Renal cell carcinoma; LUSC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg04865166 chr7:105162814 PUS7 0.52 5.92 0.31 7.79e-9 Bipolar disorder (body mass index interaction); LUSC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.48 8.25 0.41 3.61e-15 Bipolar disorder; LUSC cis rs73198271 0.595 rs117424193 chr8:8591377 T/C cg01851573 chr8:8652454 MFHAS1 0.46 5.77 0.3 1.83e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2777491 1.000 rs2730057 chr15:41736275 C/A cg18705301 chr15:41695430 NDUFAF1 -0.71 -12.97 -0.58 1.96e-31 Ulcerative colitis; LUSC trans rs61931739 0.513 rs10772116 chr12:33897795 G/C cg13010199 chr12:38710504 ALG10B 0.48 7.56 0.38 3.82e-13 Morning vs. evening chronotype; LUSC cis rs7845219 0.525 rs3019175 chr8:95949013 G/A cg16049864 chr8:95962084 TP53INP1 -0.46 -7.4 -0.38 1.09e-12 Type 2 diabetes; LUSC cis rs7582720 1.000 rs72932793 chr2:203701004 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs925550 0.560 rs17006053 chr4:123629661 C/A cg10495464 chr4:123653540 BBS12;LOC729338 -0.51 -6.67 -0.34 1.08e-10 Primary biliary cholangitis; LUSC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg18876405 chr7:65276391 NA 0.56 8.91 0.44 3.3e-17 Aortic root size; LUSC cis rs12618769 0.625 rs78518453 chr2:99213899 T/C cg10123293 chr2:99228465 UNC50 0.47 7.7 0.39 1.59e-13 Bipolar disorder; LUSC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.38 0.53 1.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4642101 0.561 rs9831765 chr3:12805934 A/T cg24848339 chr3:12840334 CAND2 0.31 6.19 0.32 1.75e-9 QRS complex (12-leadsum); LUSC cis rs3857536 0.813 rs6904511 chr6:66939102 A/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs7091068 0.754 rs6583903 chr10:95422174 T/C cg20715218 chr10:95462985 C10orf4 0.58 6.61 0.34 1.56e-10 Urinary tract infection frequency; LUSC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.87 0.4 4.87e-14 Bipolar disorder; LUSC cis rs10992471 0.580 rs1535756 chr9:95202032 G/A cg14631576 chr9:95140430 CENPP -0.36 -6.5 -0.34 2.94e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7605827 0.930 rs13001923 chr2:15521264 A/T cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.82e-17 Educational attainment (years of education); LUSC cis rs11190604 1.000 rs7099965 chr10:102301165 A/G cg23241863 chr10:102295624 HIF1AN 0.47 5.65 0.3 3.41e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs17270561 0.609 rs9393655 chr6:25711338 A/G cg16482183 chr6:26056742 HIST1H1C 0.66 9.2 0.45 4e-18 Iron status biomarkers; LUSC cis rs3820928 0.904 rs2217359 chr2:227759892 C/T cg11843606 chr2:227700838 RHBDD1 -0.54 -7.86 -0.4 5.36e-14 Pulmonary function; LUSC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg13902645 chr11:5959945 NA -0.54 -8.03 -0.4 1.73e-14 DNA methylation (variation); LUSC cis rs9790314 0.846 rs13083229 chr3:161008125 G/A cg03342759 chr3:160939853 NMD3 -0.57 -9.84 -0.47 3.07e-20 Morning vs. evening chronotype; LUSC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg03929089 chr4:120376271 NA -0.94 -14.95 -0.63 4.73e-39 Coronary artery disease; LUSC cis rs6977660 0.619 rs4721823 chr7:19785888 G/C cg05791153 chr7:19748676 TWISTNB 0.62 6.33 0.33 7.74e-10 Thyroid stimulating hormone; LUSC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.83 0.35 3.98e-11 Platelet count; LUSC cis rs12541635 1.000 rs2881037 chr8:107090901 C/T cg10147462 chr8:107024639 NA -0.47 -8.64 -0.43 2.37e-16 Age of smoking initiation; LUSC cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg11244672 chr19:19639970 YJEFN3 -0.61 -7.59 -0.38 3.3e-13 Bipolar disorder; LUSC cis rs116988415 0.584 rs17180252 chr14:65239316 G/A cg25083366 chr14:65239357 SPTB 0.7 6.65 0.34 1.19e-10 Daytime sleep phenotypes; LUSC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg09365446 chr1:150670422 GOLPH3L 0.47 6.83 0.35 4.12e-11 Melanoma; LUSC trans rs7647973 0.626 rs62262722 chr3:49769419 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.59 6.7 0.34 8.7e-11 Menarche (age at onset); LUSC trans rs561341 1.000 rs8077092 chr17:30281992 T/C cg20587970 chr11:113659929 NA -1.07 -14.87 -0.63 1.01e-38 Hip circumference adjusted for BMI; LUSC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC trans rs6598955 0.671 rs12089149 chr1:26638500 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.62 -8.0 -0.4 2.09e-14 Obesity-related traits; LUSC cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg18132916 chr6:79620363 NA -0.38 -5.74 -0.3 2.09e-8 Intelligence (multi-trait analysis); LUSC cis rs10465746 0.967 rs11163874 chr1:84424437 G/C cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.01e-9 Obesity-related traits; LUSC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.12 0.48 3.52e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg08048268 chr3:133502702 NA -0.38 -6.92 -0.35 2.25e-11 Iron status biomarkers; LUSC cis rs11748023 0.605 rs155943 chr5:139529987 A/T cg26211634 chr5:139558579 C5orf32 0.35 6.29 0.33 9.86e-10 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg07092213 chr7:1199455 ZFAND2A -0.53 -8.64 -0.43 2.32e-16 Longevity;Endometriosis; LUSC cis rs858239 0.601 rs929507 chr7:23166664 G/C cg23682824 chr7:23144976 KLHL7 0.4 5.82 0.3 1.4e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs10832963 0.847 rs4237722 chr11:18639363 T/C cg20219074 chr11:18656078 SPTY2D1 0.75 10.99 0.52 3.5e-24 Breast cancer; LUSC cis rs61990749 0.597 rs72685264 chr14:78152998 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.61 -6.49 -0.33 3.14e-10 Fibroblast growth factor basic levels; LUSC trans rs8002861 0.664 rs1466005 chr13:44424210 T/C cg12856521 chr11:46389249 DGKZ 0.44 6.6 0.34 1.64e-10 Leprosy; LUSC cis rs7539409 0.651 rs969724 chr1:84300712 T/G cg10977910 chr1:84465055 TTLL7 0.71 7.5 0.38 5.92e-13 Alzheimer's disease; LUSC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg18765753 chr7:1198926 ZFAND2A -0.59 -11.2 -0.52 6.23e-25 Longevity;Endometriosis; LUSC cis rs62458065 0.850 rs62458100 chr7:32473142 C/G cg20159608 chr7:32802032 NA -0.66 -7.83 -0.39 6.35e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg12011299 chr4:100065546 ADH4 0.68 10.52 0.5 1.52e-22 Alcohol dependence; LUSC cis rs2522056 0.932 rs1012793 chr5:131781345 G/C cg24060327 chr5:131705240 SLC22A5 0.48 6.73 0.35 7.49e-11 Lymphocyte counts;Fibrinogen; LUSC cis rs68170813 0.605 rs2299428 chr7:107134384 A/G cg24556660 chr7:106842632 COG5;HBP1 -0.44 -5.9 -0.31 8.9e-9 Coronary artery disease; LUSC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); LUSC cis rs11077998 0.967 rs4789786 chr17:80504352 A/G cg10255544 chr17:80519551 FOXK2 -0.39 -6.44 -0.33 4.14e-10 Reticulocyte fraction of red cells; LUSC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.26 0.45 2.6e-18 Prudent dietary pattern; LUSC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg18876405 chr7:65276391 NA -0.58 -9.39 -0.46 9.82e-19 Aortic root size; LUSC cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC trans rs1814175 0.904 rs7924371 chr11:49620595 C/T cg15704280 chr7:45808275 SEPT13 -1.08 -21.69 -0.76 1e-65 Height; LUSC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg22532475 chr10:104410764 TRIM8 -0.32 -7.15 -0.36 5.59e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs939658 0.935 rs34859518 chr15:79450422 A/G cg17916960 chr15:79447300 NA -0.52 -10.37 -0.49 5.1e-22 Refractive error; LUSC cis rs4704187 0.640 rs7721018 chr5:74492978 C/T cg03227963 chr5:74354835 NA 0.31 6.73 0.35 7.43e-11 Response to amphetamines; LUSC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -6.49 -0.33 3.09e-10 High light scatter reticulocyte count; LUSC trans rs10802346 0.545 rs1770012 chr1:246426405 A/G cg13514129 chr1:39547527 MACF1 0.73 11.95 0.55 1.19e-27 Fractional exhaled nitric oxide (childhood); LUSC cis rs7267979 1.000 rs2500443 chr20:25331442 C/T cg03522245 chr20:25566470 NINL -0.35 -5.69 -0.3 2.85e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg19346786 chr7:2764209 NA -0.42 -7.25 -0.37 2.94e-12 Height; LUSC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg03289416 chr15:75166202 SCAMP2 0.45 7.04 0.36 1.13e-11 Breast cancer; LUSC cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg11244672 chr19:19639970 YJEFN3 -0.64 -7.75 -0.39 1.11e-13 Bipolar disorder; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg01879757 chr17:41196368 BRCA1 -0.45 -6.99 -0.36 1.54e-11 Menopause (age at onset); LUSC cis rs2625529 0.641 rs2035379 chr15:72293202 C/T cg16672083 chr15:72433130 SENP8 -0.51 -7.44 -0.38 8.7e-13 Red blood cell count; LUSC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.9 0.31 8.71e-9 Menopause (age at onset); LUSC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg05552183 chr6:42928497 GNMT 0.52 8.58 0.42 3.71e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs4631830 0.683 rs11004409 chr10:51498019 G/C cg10326726 chr10:51549505 MSMB 0.34 5.88 0.31 9.99e-9 Prostate-specific antigen levels; LUSC cis rs10875746 0.551 rs1471997 chr12:48723595 G/A cg13454099 chr12:49076203 C12orf41 -0.49 -5.74 -0.3 2.08e-8 Longevity (90 years and older); LUSC cis rs981844 0.961 rs62325084 chr4:154662603 C/T cg14289246 chr4:154710475 SFRP2 0.5 6.44 0.33 4.05e-10 Response to statins (LDL cholesterol change); LUSC cis rs9303280 0.836 rs12453507 chr17:38053207 C/G cg19468946 chr17:37922297 IKZF3 -0.41 -6.35 -0.33 6.91e-10 Self-reported allergy; LUSC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg09365446 chr1:150670422 GOLPH3L -0.42 -6.39 -0.33 5.42e-10 Tonsillectomy; LUSC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg09365446 chr1:150670422 GOLPH3L 0.53 8.05 0.4 1.46e-14 Tonsillectomy; LUSC cis rs7769051 0.711 rs7770081 chr6:133089569 G/T cg07930552 chr6:133119739 C6orf192 0.76 10.16 0.49 2.56e-21 Type 2 diabetes nephropathy; LUSC cis rs10752881 1.000 rs12403189 chr1:182983832 G/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.53 0.5 1.37e-22 Colorectal cancer; LUSC trans rs877282 0.947 rs957642 chr10:773966 C/T cg13042288 chr15:90349979 ANPEP -0.49 -7.21 -0.37 3.86e-12 Uric acid levels; LUSC cis rs9302635 0.513 rs8061282 chr16:72155938 C/T cg01557791 chr16:72042693 DHODH -0.47 -6.05 -0.31 3.94e-9 Blood protein levels; LUSC cis rs11677370 0.561 rs12986995 chr2:3826965 G/A cg17052675 chr2:3827356 NA -0.68 -11.04 -0.52 2.39e-24 Type 2 diabetes; LUSC trans rs7939886 0.920 rs11227434 chr11:55945251 G/T cg15704280 chr7:45808275 SEPT13 0.87 6.66 0.34 1.1e-10 Myopia (pathological); LUSC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.26 0.45 2.6e-18 Prudent dietary pattern; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02930664 chr19:44506841 ZNF230 -0.42 -6.13 -0.32 2.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg03188948 chr7:1209495 NA 0.42 5.67 0.3 3.09e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg22705228 chr6:37400926 FTSJD2 0.52 6.36 0.33 6.52e-10 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6502050 0.835 rs4789675 chr17:80123144 G/A cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.71e-10 Life satisfaction; LUSC cis rs4132509 0.948 rs12048930 chr1:243940076 C/T cg21452805 chr1:244014465 NA 0.51 5.71 0.3 2.51e-8 RR interval (heart rate); LUSC cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg00071950 chr4:10020882 SLC2A9 0.45 7.65 0.39 2.13e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11792861 0.816 rs3818932 chr9:111664178 T/C cg05043794 chr9:111880884 C9orf5 -0.33 -6.88 -0.35 2.97e-11 Menarche (age at onset); LUSC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg07636037 chr3:49044803 WDR6 0.69 8.88 0.44 4.05e-17 Menarche (age at onset); LUSC cis rs11748023 0.605 rs155949 chr5:139523684 A/G cg26211634 chr5:139558579 C5orf32 0.34 6.18 0.32 1.85e-9 Intelligence (multi-trait analysis); LUSC cis rs9814567 0.712 rs9838119 chr3:134331980 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.78 -12.62 -0.57 4.01e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs440932 0.757 rs330943 chr8:9021026 G/A cg06636001 chr8:8085503 FLJ10661 0.42 5.99 0.31 5.53e-9 High light scatter reticulocyte percentage of red cells; LUSC cis rs9914988 0.887 rs12451790 chr17:27112000 C/G cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs10876993 0.806 rs1689598 chr12:58050500 G/C cg18357645 chr12:58087776 OS9 0.52 7.81 0.39 7.27e-14 Celiac disease or Rheumatoid arthritis; LUSC trans rs1486139 1.000 rs1486156 chr7:46289564 G/A cg17534202 chr9:96721102 NA -0.37 -6.64 -0.34 1.3e-10 Select biomarker traits; LUSC cis rs17253792 0.822 rs111467375 chr14:56046159 T/G cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 8.91e-12 Putamen volume; LUSC cis rs738322 0.775 rs4375 chr22:38539041 T/C cg25457927 chr22:38595422 NA -0.4 -7.85 -0.39 5.85e-14 Cutaneous nevi; LUSC cis rs9311676 0.632 rs56398717 chr3:58404355 G/A cg26110898 chr3:58419937 PDHB 0.39 6.31 0.33 9.11e-10 Systemic lupus erythematosus; LUSC cis rs7267979 1.000 rs2027004 chr20:25350618 C/T cg03522245 chr20:25566470 NINL -0.36 -5.8 -0.3 1.56e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg15744005 chr10:104629667 AS3MT -0.38 -7.93 -0.4 3.22e-14 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs11249608 0.548 rs2132671 chr5:178457434 A/G cg21905437 chr5:178450457 ZNF879 -0.43 -5.88 -0.31 9.69e-9 Pubertal anthropometrics; LUSC cis rs9549367 0.756 rs9603814 chr13:113900782 C/T cg18105134 chr13:113819100 PROZ 0.61 9.08 0.44 9.89e-18 Platelet distribution width; LUSC cis rs9398803 0.830 rs4053271 chr6:126830512 T/C cg19875578 chr6:126661172 C6orf173 0.42 6.17 0.32 1.97e-9 Male-pattern baldness; LUSC cis rs416603 0.967 rs11640138 chr16:11362729 A/G cg00044050 chr16:11439710 C16orf75 0.65 11.61 0.54 2.09e-26 Type 1 diabetes; LUSC cis rs1113500 0.787 rs10881501 chr1:108641745 C/T cg06207961 chr1:108661230 NA 0.3 5.66 0.3 3.18e-8 Growth-regulated protein alpha levels; LUSC cis rs9534288 0.830 rs3783202 chr13:46631869 G/A cg15192986 chr13:46630673 CPB2 -0.8 -12.69 -0.57 2.14e-30 Blood protein levels; LUSC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg12257692 chr3:49977190 RBM6 -0.23 -6.38 -0.33 5.75e-10 Body mass index; LUSC cis rs7589342 0.501 rs7602971 chr2:106440675 G/A cg14210321 chr2:106509881 NCK2 -0.41 -6.11 -0.32 2.77e-9 Addiction; LUSC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg26958806 chr6:27640298 NA -0.65 -5.72 -0.3 2.38e-8 Depression; LUSC cis rs11608355 0.846 rs4766471 chr12:109853462 G/A cg19025524 chr12:109796872 NA -0.39 -5.72 -0.3 2.35e-8 Neuroticism; LUSC cis rs9549260 0.755 rs7986407 chr13:41179798 A/G cg21288729 chr13:41239152 FOXO1 0.6 8.74 0.43 1.16e-16 Red blood cell count; LUSC cis rs9309473 0.687 rs6706409 chr2:73606508 G/T cg20560298 chr2:73613845 ALMS1 0.52 7.51 0.38 5.39e-13 Metabolite levels; LUSC cis rs8141529 0.732 rs11556025 chr22:29168755 T/C cg02153584 chr22:29168773 CCDC117 0.68 10.54 0.5 1.26e-22 Lymphocyte counts; LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs9287719 0.967 rs2110776 chr2:10748810 A/G cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs6088590 1.000 rs11698996 chr20:33449739 C/G cg24642439 chr20:33292090 TP53INP2 0.66 9.78 0.47 4.96e-20 Coronary artery disease; LUSC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -7.23 -0.37 3.4e-12 Alzheimer's disease (late onset); LUSC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg19592336 chr6:28129416 ZNF389 0.51 6.58 0.34 1.8e-10 Depression; LUSC trans rs4927850 1.000 rs4927850 chr3:195751630 C/T cg16724585 chr3:197361211 NA 0.61 8.54 0.42 4.9e-16 Pancreatic cancer; LUSC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg18479299 chr3:125709523 NA -0.52 -5.94 -0.31 7.16e-9 Blood pressure (smoking interaction); LUSC cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg25456477 chr12:86230367 RASSF9 0.4 6.91 0.35 2.42e-11 Major depressive disorder; LUSC cis rs12478296 0.591 rs12468297 chr2:242996474 A/G cg06360820 chr2:242988706 NA -0.6 -7.8 -0.39 7.89e-14 Obesity-related traits; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26317405 chr11:67188521 ATPGD1 0.8 6.28 0.32 1.06e-9 Cognitive performance; LUSC trans rs11098499 0.909 rs79704848 chr4:120309351 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs259282 0.538 rs8105481 chr19:33118095 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.73 10.46 0.5 2.52e-22 Schizophrenia; LUSC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.47 7.79 0.39 8.53e-14 Bone mineral density (spine);Bone mineral density; LUSC cis rs17253792 0.822 rs79483507 chr14:56164718 G/T cg01858014 chr14:56050164 KTN1 -0.88 -7.08 -0.36 8.38e-12 Putamen volume; LUSC trans rs1814175 0.791 rs11040472 chr11:49703116 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.19 -0.8 2.08e-75 Height; LUSC cis rs12286929 0.933 rs11215381 chr11:115022233 T/C cg04055981 chr11:115044050 NA 0.36 6.29 0.33 1.02e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11997175 0.597 rs6988880 chr8:33594504 C/T ch.8.33884649F chr8:33765107 NA 0.42 6.66 0.34 1.15e-10 Body mass index; LUSC trans rs1991651 0.578 rs11778453 chr8:10489836 C/G cg06636001 chr8:8085503 FLJ10661 -0.42 -6.05 -0.31 3.85e-9 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg12016809 chr21:47604291 C21orf56 0.47 7.03 0.36 1.18e-11 Testicular germ cell tumor; LUSC cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg11244672 chr19:19639970 YJEFN3 -0.52 -6.68 -0.34 9.85e-11 Bipolar disorder; LUSC cis rs870825 0.616 rs6825561 chr4:185615532 A/T cg04058563 chr4:185651563 MLF1IP 0.87 13.5 0.59 1.86e-33 Blood protein levels; LUSC trans rs35110281 0.667 rs2070533 chr21:45122753 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.62 10.5 0.5 1.77e-22 Mean corpuscular volume; LUSC cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg02503808 chr4:7069936 GRPEL1 1.07 14.49 0.62 2.9e-37 Monocyte percentage of white cells; LUSC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg25811766 chr13:21894605 NA 0.79 9.71 0.47 8.23e-20 White matter hyperintensity burden; LUSC cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg13010199 chr12:38710504 ALG10B -0.63 -10.7 -0.51 3.65e-23 Heart rate; LUSC cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg05283184 chr6:79620031 NA -0.57 -12.18 -0.55 1.73e-28 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.626 rs10854486 chr21:45118280 G/T cg21573476 chr21:45109991 RRP1B -0.36 -5.7 -0.3 2.66e-8 Mean corpuscular volume; LUSC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg18252515 chr7:66147081 NA -1.25 -14.0 -0.61 2.4e-35 Diabetic kidney disease; LUSC cis rs790123 1.000 rs790115 chr3:122381117 C/T cg00926285 chr3:122398533 PARP14 -0.38 -5.83 -0.3 1.33e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs238295 0.805 rs6085211 chr20:5552847 G/C cg15842884 chr20:5591925 RP5-1022P6.2 -0.44 -5.94 -0.31 7.34e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs1395 0.626 rs72817537 chr2:27497549 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.45 6.34 0.33 7.49e-10 Blood metabolite levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg09856410 chr20:34287384 ROMO1;NFS1 -0.41 -6.07 -0.32 3.48e-9 Electrocardiographic conduction measures; LUSC cis rs2625529 0.761 rs972029 chr15:72172986 C/T cg16672083 chr15:72433130 SENP8 -0.45 -6.61 -0.34 1.53e-10 Red blood cell count; LUSC cis rs709400 0.659 rs3825566 chr14:103852725 C/T cg12935359 chr14:103987150 CKB 0.54 8.26 0.41 3.46e-15 Body mass index; LUSC trans rs4332037 0.624 rs58169303 chr7:1883274 T/C cg25206134 chr2:45395956 NA 0.52 6.22 0.32 1.52e-9 Bipolar disorder; LUSC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg10792982 chr14:105748885 BRF1 0.52 9.51 0.46 4.05e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs524023 0.837 rs12362590 chr11:64352540 T/A cg19131476 chr11:64387923 NRXN2 -0.37 -9.81 -0.47 3.83e-20 Urate levels in obese individuals; LUSC cis rs4253772 0.872 rs45576140 chr22:46638216 C/G cg09491104 chr22:46646882 C22orf40 -0.59 -6.48 -0.33 3.23e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg18099408 chr3:52552593 STAB1 -0.42 -7.28 -0.37 2.44e-12 Electroencephalogram traits; LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg07395648 chr5:131743802 NA 0.37 5.87 0.31 1.07e-8 Breast cancer; LUSC cis rs7826238 0.509 rs2948288 chr8:8115304 A/G cg14343924 chr8:8086146 FLJ10661 0.43 5.93 0.31 7.77e-9 Systolic blood pressure; LUSC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 10.09 0.48 4.6e-21 Bipolar disorder; LUSC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC cis rs6570726 0.967 rs9403706 chr6:145795187 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -12.27 -0.56 8e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg12667521 chr19:29218732 NA 0.62 7.48 0.38 6.7e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs3768617 0.510 rs2296290 chr1:183079412 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.84 0.51 1.15e-23 Fuchs's corneal dystrophy; LUSC cis rs1568889 0.838 rs7131379 chr11:28085789 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.89 0.58 3.95e-31 Bipolar disorder; LUSC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg27532560 chr4:187881888 NA -0.43 -6.95 -0.36 1.87e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs12760731 0.720 rs12161419 chr1:178379040 A/C cg00404053 chr1:178313656 RASAL2 0.6 6.25 0.32 1.26e-9 Obesity-related traits; LUSC cis rs7824557 0.527 rs10109537 chr8:11239640 C/T cg12568669 chr8:11666485 FDFT1 0.26 5.78 0.3 1.72e-8 Retinal vascular caliber; LUSC trans rs71435601 0.574 rs522822 chr2:21401851 A/G cg20757404 chr19:378427 NA 0.38 6.0 0.31 5.1e-9 Cholesterol, total; LUSC cis rs10986311 0.775 rs1007185 chr9:127136644 G/C cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.44 -7.21 -0.37 3.8e-12 Vitiligo; LUSC cis rs710216 0.957 rs859511 chr1:43430260 C/T cg03128534 chr1:43423976 SLC2A1 0.47 5.8 0.3 1.54e-8 Red cell distribution width; LUSC trans rs7937682 0.883 rs486038 chr11:111465963 A/C cg18187862 chr3:45730750 SACM1L 0.53 6.78 0.35 5.31e-11 Primary sclerosing cholangitis; LUSC cis rs10751667 0.666 rs7483273 chr11:951127 T/C ch.11.42038R chr11:967971 AP2A2 0.42 6.28 0.33 1.03e-9 Alzheimer's disease (late onset); LUSC cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg09021430 chr5:549028 NA -0.58 -9.11 -0.45 7.58e-18 Obesity-related traits; LUSC cis rs9303401 0.646 rs9303403 chr17:57219300 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.48 -7.46 -0.38 7.49e-13 Cognitive test performance; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12728516 chr1:155197152 GBAP1 0.5 5.95 0.31 6.74e-9 Bipolar disorder and schizophrenia; LUSC cis rs1865760 0.519 rs2275904 chr6:25768085 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 7.55 0.38 4.18e-13 Height; LUSC trans rs4332037 0.950 rs62442895 chr7:1936938 G/A cg10840412 chr1:235813424 GNG4 0.67 8.97 0.44 2.19e-17 Bipolar disorder; LUSC cis rs9527 0.615 rs7089065 chr10:104723022 C/T cg05855489 chr10:104503620 C10orf26 0.52 8.08 0.4 1.19e-14 Arsenic metabolism; LUSC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg12311346 chr5:56204834 C5orf35 -0.63 -9.14 -0.45 6.15e-18 Coronary artery disease; LUSC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.45 5.98 0.31 5.64e-9 Renal function-related traits (BUN); LUSC cis rs10752881 1.000 rs10797800 chr1:182969828 C/A ch.1.3577855R chr1:183094577 LAMC1 0.67 10.29 0.49 9.56e-22 Colorectal cancer; LUSC cis rs7208859 0.623 rs76633166 chr17:29113365 C/T cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7914558 0.902 rs3736922 chr10:104850632 A/G cg23093090 chr10:104574429 C10orf26 0.31 5.65 0.3 3.52e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg18107078 chr1:162760321 HSD17B7 -0.46 -6.6 -0.34 1.61e-10 Breast cancer; LUSC cis rs3105593 0.933 rs7174839 chr15:50889624 G/C cg08437265 chr15:50716283 USP8 0.4 5.92 0.31 8.09e-9 QT interval; LUSC cis rs9392556 0.829 rs634698 chr6:4114247 T/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.2 -0.32 1.71e-9 Blood metabolite levels; LUSC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg17724175 chr1:150552817 MCL1 0.37 6.7 0.34 8.92e-11 Tonsillectomy; LUSC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg18190219 chr22:46762943 CELSR1 -0.48 -5.69 -0.3 2.78e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg25258033 chr6:167368657 RNASET2 0.47 7.85 0.39 5.71e-14 Crohn's disease; LUSC cis rs1728785 1.000 rs1749792 chr16:68569440 T/G cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC cis rs738322 0.719 rs34066050 chr22:38612604 G/A cg25457927 chr22:38595422 NA 0.45 9.31 0.45 1.8e-18 Cutaneous nevi; LUSC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg21963583 chr11:68658836 MRPL21 -0.57 -8.83 -0.44 5.92e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg19592336 chr6:28129416 ZNF389 -0.51 -6.94 -0.35 2.09e-11 Depression; LUSC cis rs926938 0.520 rs6671984 chr1:115257521 C/T cg12756093 chr1:115239321 AMPD1 -0.55 -8.04 -0.4 1.57e-14 Autism; LUSC cis rs1595825 1.000 rs1440088 chr2:198871417 A/C cg00982548 chr2:198649783 BOLL -0.48 -6.04 -0.31 4.21e-9 Ulcerative colitis; LUSC cis rs6429082 0.738 rs2131921 chr1:235705157 C/T cg26050004 chr1:235667680 B3GALNT2 0.41 5.71 0.3 2.53e-8 Adiposity; LUSC cis rs72781680 0.898 rs72780111 chr2:23991146 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs193541 0.632 rs6878609 chr5:122095549 C/G cg19077854 chr5:122220652 SNX24 0.39 7.99 0.4 2.18e-14 Glucose homeostasis traits; LUSC trans rs7647973 0.593 rs58339610 chr3:49845006 T/A cg21659725 chr3:3221576 CRBN 0.71 8.52 0.42 5.73e-16 Menarche (age at onset); LUSC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg22875332 chr1:76189707 ACADM 0.85 15.63 0.65 9.87e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4812048 0.696 rs6070694 chr20:57591126 G/A cg14073986 chr20:57617431 SLMO2 0.76 6.79 0.35 5.29e-11 Mean platelet volume; LUSC cis rs1113500 0.614 rs12565953 chr1:108607087 C/T cg06207961 chr1:108661230 NA 0.36 5.74 0.3 2.09e-8 Growth-regulated protein alpha levels; LUSC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg06808227 chr14:105710500 BRF1 -0.71 -11.31 -0.53 2.47e-25 Mean platelet volume;Platelet distribution width; LUSC cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg23029597 chr12:123009494 RSRC2 -0.76 -10.03 -0.48 7.17e-21 Body mass index; LUSC cis rs9815354 0.812 rs73077361 chr3:41850146 G/A cg03022575 chr3:42003672 ULK4 0.85 8.56 0.42 4.04e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs1448094 0.935 rs10746355 chr12:86330227 A/T cg00310523 chr12:86230176 RASSF9 0.37 6.59 0.34 1.76e-10 Major depressive disorder; LUSC cis rs2839186 0.872 rs13052233 chr21:47707284 G/T cg11766577 chr21:47581405 C21orf56 -0.42 -6.16 -0.32 2.15e-9 Testicular germ cell tumor; LUSC cis rs7769051 1.000 rs12204027 chr6:133122831 A/G cg22852734 chr6:133119734 C6orf192 1.22 14.16 0.61 5.69e-36 Type 2 diabetes nephropathy; LUSC trans rs11696501 0.739 rs2281210 chr20:44243172 T/G cg03272292 chr12:48577362 C12orf68 0.52 6.18 0.32 1.88e-9 Brain structure; LUSC cis rs7177699 0.557 rs7403714 chr15:79118650 C/T cg15571903 chr15:79123663 NA -0.33 -6.03 -0.31 4.24e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs3809566 1.000 rs4775610 chr15:63332057 C/T cg00520135 chr15:63333846 TPM1 0.33 6.56 0.34 2e-10 Platelet count; LUSC cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.74 0.84 1.09e-88 Chronic sinus infection; LUSC cis rs3820068 0.608 rs7552400 chr1:16035892 A/G cg24675056 chr1:15929824 NA 0.4 6.58 0.34 1.87e-10 Systolic blood pressure; LUSC cis rs9399401 0.961 rs1891308 chr6:142648235 G/A cg03128060 chr6:142623767 GPR126 0.32 5.67 0.3 3.01e-8 Chronic obstructive pulmonary disease; LUSC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg17971929 chr21:40555470 PSMG1 0.81 14.13 0.61 7.23e-36 Cognitive function; LUSC cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg08742575 chr21:47604166 C21orf56 0.4 6.0 0.31 5.24e-9 Testicular germ cell tumor; LUSC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg16339924 chr4:17578868 LAP3 0.48 7.24 0.37 3.13e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1971762 0.583 rs1527068 chr12:54088688 A/G cg23533419 chr12:54090519 NA -0.38 -6.23 -0.32 1.41e-9 Height; LUSC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.92 0.31 7.96e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9916302 0.706 rs4488484 chr17:37717377 A/T cg07936489 chr17:37558343 FBXL20 0.8 10.35 0.49 5.79e-22 Glomerular filtration rate (creatinine); LUSC cis rs10782582 0.617 rs1846233 chr1:76159354 C/T cg10523679 chr1:76189770 ACADM -0.49 -7.26 -0.37 2.66e-12 Daytime sleep phenotypes; LUSC cis rs1865760 0.929 rs9467646 chr6:25957408 A/G cg16482183 chr6:26056742 HIST1H1C 0.42 6.05 0.31 3.97e-9 Height; LUSC cis rs7582180 0.629 rs11686799 chr2:100956055 C/G cg12002119 chr2:101014098 CHST10 0.35 5.65 0.3 3.35e-8 Intelligence (multi-trait analysis); LUSC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.42 6.95 0.36 1.97e-11 Cystic fibrosis severity; LUSC cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.55 -0.38 4.24e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs611744 0.647 rs7015240 chr8:109262204 G/A cg21045802 chr8:109455806 TTC35 0.43 6.66 0.34 1.15e-10 Dupuytren's disease; LUSC cis rs11931598 0.702 rs10937780 chr4:7048842 A/G cg02503808 chr4:7069936 GRPEL1 -0.42 -6.32 -0.33 8.51e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs7249142 0.561 rs4808185 chr19:19296217 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.47 7.52 0.38 5.07e-13 IgG glycosylation; LUSC cis rs9309473 1.000 rs6707722 chr2:73654363 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.54 -0.34 2.34e-10 Metabolite levels; LUSC cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg21535247 chr6:8435926 SLC35B3 0.59 9.08 0.44 9.64e-18 Motion sickness; LUSC cis rs751728 0.931 rs2296746 chr6:33744711 C/T cg25922239 chr6:33757077 LEMD2 0.55 8.38 0.42 1.53e-15 Crohn's disease; LUSC cis rs10779751 0.734 rs2259886 chr1:11137778 C/T cg04508216 chr1:11107452 MASP2 0.32 5.87 0.31 1.05e-8 Body mass index; LUSC cis rs9287719 0.934 rs6727884 chr2:10757557 C/T cg03983476 chr2:10830698 NOL10 0.37 5.75 0.3 2.05e-8 Prostate cancer; LUSC cis rs8027181 0.839 rs7176235 chr15:72999104 A/G cg25632853 chr15:73088954 NA 0.32 6.62 0.34 1.47e-10 Triglyceride levels; LUSC cis rs477692 0.905 rs4751106 chr10:131424653 G/T cg26102564 chr10:131424627 MGMT -0.37 -5.79 -0.3 1.59e-8 Response to temozolomide; LUSC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg16624210 chr5:671434 TPPP 0.49 6.27 0.32 1.12e-9 Obesity-related traits; LUSC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg05340658 chr4:99064831 C4orf37 0.68 11.4 0.53 1.23e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs262150 0.714 rs2657397 chr7:158785095 C/T cg04111992 chr7:158790115 NA -0.44 -6.86 -0.35 3.34e-11 Facial morphology (factor 20); LUSC cis rs2806561 0.765 rs681395 chr1:23500314 G/A cg12483005 chr1:23474871 LUZP1 0.41 6.15 0.32 2.18e-9 Height; LUSC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.69 -10.91 -0.51 6.33e-24 Platelet count; LUSC cis rs7399018 0.739 rs10747608 chr12:51616582 A/G cg12163867 chr12:51592794 POU6F1 -0.43 -8.09 -0.4 1.13e-14 Cisplatin-induced ototoxicity; LUSC cis rs36093844 0.752 rs79734467 chr11:85571953 C/T cg25872744 chr11:85566296 CCDC83 -0.45 -5.78 -0.3 1.69e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs7615952 0.736 rs9862893 chr3:125686974 A/G cg06494592 chr3:125709126 NA -0.57 -5.83 -0.3 1.34e-8 Blood pressure (smoking interaction); LUSC cis rs17401966 0.593 rs11121523 chr1:10214442 T/A cg19773385 chr1:10388646 KIF1B -0.46 -6.59 -0.34 1.77e-10 Hepatocellular carcinoma; LUSC cis rs73206853 0.563 rs10400410 chr12:111193499 C/T cg12870014 chr12:110450643 ANKRD13A 0.64 6.47 0.33 3.51e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg04944784 chr2:26401820 FAM59B -0.68 -9.49 -0.46 4.45e-19 Gut microbiome composition (summer); LUSC cis rs113835537 0.529 rs75685325 chr11:66235242 A/G cg24851651 chr11:66362959 CCS 0.55 8.04 0.4 1.57e-14 Airway imaging phenotypes; LUSC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg22529645 chr1:3704559 LRRC47 0.36 6.2 0.32 1.69e-9 Red cell distribution width; LUSC cis rs394563 0.601 rs367133 chr6:149797720 T/G cg11245181 chr6:149772854 ZC3H12D -0.3 -6.09 -0.32 3.17e-9 Dupuytren's disease; LUSC trans rs11039798 0.698 rs78553793 chr11:48947336 C/A cg03929089 chr4:120376271 NA 0.74 6.31 0.33 9.03e-10 Axial length; LUSC cis rs6723108 0.702 rs55920206 chr2:135432066 C/T cg12500956 chr2:135428796 TMEM163 -0.29 -6.9 -0.35 2.63e-11 Type 2 diabetes; LUSC trans rs7829975 0.688 rs7827182 chr8:8380471 C/G cg21775007 chr8:11205619 TDH 0.44 6.57 0.34 1.96e-10 Mood instability; LUSC cis rs2274273 0.870 rs10145203 chr14:55784458 A/C cg04306507 chr14:55594613 LGALS3 0.54 11.84 0.54 2.97e-27 Protein biomarker; LUSC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.54 7.48 0.38 6.51e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4664308 1.000 rs6759836 chr2:160912802 C/T cg03641300 chr2:160917029 PLA2R1 -0.68 -11.38 -0.53 1.38e-25 Idiopathic membranous nephropathy; LUSC cis rs2408955 0.521 rs7301003 chr12:48550227 A/G cg24011408 chr12:48396354 COL2A1 0.39 5.79 0.3 1.59e-8 Glycated hemoglobin levels; LUSC cis rs6547741 1.000 rs4665381 chr2:27757150 A/C cg12559939 chr2:27858050 GPN1 0.4 6.4 0.33 5.28e-10 Oral cavity cancer; LUSC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg03806693 chr22:41940476 POLR3H 0.96 13.48 0.59 2.28e-33 Vitiligo; LUSC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg15001381 chr16:403314 AXIN1 0.35 6.5 0.34 2.94e-10 Bone mineral density (spine);Bone mineral density; LUSC trans rs11949289 1.000 rs58572175 chr5:28343587 A/G cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.57e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg26335602 chr6:28129616 ZNF389 0.46 6.06 0.31 3.64e-9 Depression; LUSC cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg21782813 chr7:2030301 MAD1L1 0.6 10.42 0.5 3.26e-22 Bipolar disorder and schizophrenia; LUSC cis rs7809950 0.678 rs62482507 chr7:107024488 T/G cg23024343 chr7:107201750 COG5 -0.68 -9.93 -0.48 1.52e-20 Coronary artery disease; LUSC cis rs6835098 0.962 rs10027704 chr4:174083107 T/C cg08422745 chr4:174089978 GALNT7 -0.84 -13.81 -0.6 1.25e-34 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.1 -0.36 7.33e-12 Major depressive disorder; LUSC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg07936489 chr17:37558343 FBXL20 0.71 9.96 0.48 1.21e-20 Glomerular filtration rate (creatinine); LUSC trans rs890100 0.902 rs971447 chr2:56737876 T/C cg08299783 chr2:48920986 GTF2A1L;LHCGR -0.31 -6.07 -0.32 3.5e-9 Gut microbiome composition (summer); LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg03909863 chr11:638404 DRD4 -0.41 -6.19 -0.32 1.81e-9 Systemic lupus erythematosus; LUSC cis rs35306767 0.714 rs12783621 chr10:1083304 C/T cg20503657 chr10:835505 NA 0.54 7.17 0.37 4.71e-12 Eosinophil percentage of granulocytes; LUSC cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg04455712 chr21:45112962 RRP1B -0.45 -8.87 -0.44 4.43e-17 Mean corpuscular volume; LUSC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg26408565 chr15:76604113 ETFA -0.53 -8.69 -0.43 1.65e-16 Blood metabolite levels; LUSC trans rs853679 0.599 rs149990 chr6:27998258 G/A cg06606381 chr12:133084897 FBRSL1 -0.65 -7.14 -0.36 5.94e-12 Depression; LUSC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg06740227 chr12:86229804 RASSF9 0.38 6.06 0.31 3.64e-9 Major depressive disorder; LUSC cis rs61931739 0.635 rs1601627 chr12:33962420 G/A cg06521331 chr12:34319734 NA -0.41 -6.72 -0.35 7.9e-11 Morning vs. evening chronotype; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13401104 0.796 rs10929168 chr2:237115373 C/T cg19324714 chr2:237145437 ASB18 -0.42 -5.88 -0.31 9.68e-9 Educational attainment; LUSC cis rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05901451 chr6:126070800 HEY2 0.75 12.09 0.55 3.82e-28 Endometrial cancer; LUSC cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.87e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11809207 1.000 rs55695238 chr1:26521931 C/G cg00300879 chr1:26503847 CNKSR1 0.31 5.87 0.31 1.05e-8 Height; LUSC cis rs7923609 1.000 rs10822149 chr10:64987412 G/A cg01631684 chr10:65280961 REEP3 -0.4 -6.26 -0.32 1.19e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs4409675 0.576 rs2078328 chr1:28224976 A/G cg23691781 chr1:28212827 C1orf38 0.31 7.43 0.38 9.31e-13 Corneal astigmatism; LUSC cis rs950169 0.881 rs150965 chr15:85080527 T/G cg17507749 chr15:85114479 UBE2QP1 0.7 8.8 0.43 7.23e-17 Schizophrenia; LUSC cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg07741184 chr6:167504864 NA 0.33 5.99 0.31 5.45e-9 Crohn's disease; LUSC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg08219700 chr8:58056026 NA 0.66 8.38 0.42 1.46e-15 Developmental language disorder (linguistic errors); LUSC cis rs6961069 0.585 rs10268404 chr7:80239813 C/T cg04458919 chr7:80252533 CD36 -0.4 -7.32 -0.37 1.91e-12 Platelet count; LUSC cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg26395211 chr5:140044315 WDR55 0.46 7.11 0.36 6.88e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.75 -0.35 6.6e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8127571 0.551 rs2838986 chr21:47145374 C/T cg11214348 chr21:47283868 PCBP3 0.43 6.16 0.32 2.11e-9 Immune reponse to smallpox (secreted IFN-alpha); LUSC cis rs6696846 0.740 rs12125465 chr1:205074854 C/A cg21545522 chr1:205238299 TMCC2 0.46 8.63 0.43 2.61e-16 Red blood cell count; LUSC cis rs932287 0.858 rs7109896 chr11:9054522 A/G cg12365402 chr11:9010492 NRIP3 0.35 5.98 0.31 5.73e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs72781680 0.821 rs55948613 chr2:24094787 A/G cg08917208 chr2:24149416 ATAD2B 0.6 6.98 0.36 1.59e-11 Lymphocyte counts; LUSC cis rs7808935 0.958 rs17156041 chr7:27975745 C/T cg22168087 chr7:27702803 HIBADH 0.6 6.86 0.35 3.39e-11 Prostate cancer; LUSC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg06008330 chr7:65541103 ASL 0.39 6.09 0.32 3.19e-9 Aortic root size; LUSC trans rs6582630 0.502 rs4379906 chr12:38295673 G/A cg06521331 chr12:34319734 NA -0.42 -6.53 -0.34 2.48e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg25208724 chr1:156163844 SLC25A44 1.03 23.14 0.78 2.27e-71 Testicular germ cell tumor; LUSC cis rs41271473 1.000 rs4641285 chr1:228878663 G/A cg16512390 chr1:228756714 NA 0.5 6.04 0.31 4.05e-9 Chronic lymphocytic leukemia; LUSC cis rs11864453 0.713 rs6680 chr16:72146570 T/C cg01557791 chr16:72042693 DHODH -0.49 -7.16 -0.36 5.32e-12 Fibrinogen levels; LUSC cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg15103426 chr22:29168792 CCDC117 0.45 5.87 0.31 1.06e-8 Lymphocyte counts; LUSC cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs9611565 0.649 rs4822050 chr22:42177453 C/G cg03806693 chr22:41940476 POLR3H -0.72 -9.97 -0.48 1.19e-20 Vitiligo; LUSC cis rs5769765 0.955 rs2319465 chr22:50265784 A/C cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg26335602 chr6:28129616 ZNF389 0.43 5.77 0.3 1.79e-8 Depression; LUSC cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.91 -0.4 3.77e-14 Chronic sinus infection; LUSC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.74 0.35 7.06e-11 Menarche (age at onset); LUSC cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg00012203 chr2:219082015 ARPC2 -0.77 -13.72 -0.6 2.88e-34 Colorectal cancer; LUSC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg09365446 chr1:150670422 GOLPH3L 0.45 6.29 0.33 9.89e-10 Tonsillectomy; LUSC cis rs61931739 0.500 rs10844734 chr12:34043083 G/A cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.05e-15 Morning vs. evening chronotype; LUSC cis rs8017423 0.935 rs11159960 chr14:90740012 C/T cg14092571 chr14:90743983 NA 0.36 5.77 0.3 1.78e-8 Mortality in heart failure; LUSC cis rs2607426 0.681 rs60533951 chr19:41300484 G/A cg05508168 chr19:41255947 C19orf54;SNRPA 1.0 6.8 0.35 4.87e-11 Blood protein levels; LUSC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg13647721 chr17:30228624 UTP6 0.62 6.05 0.31 3.95e-9 Hip circumference adjusted for BMI; LUSC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg09359103 chr1:154839909 KCNN3 -0.69 -15.95 -0.66 5.7e-43 Prostate cancer; LUSC cis rs9902453 0.765 rs2447935 chr17:28057524 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.18 -0.52 7.56e-25 Coffee consumption (cups per day); LUSC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.44 -6.58 -0.34 1.85e-10 Menarche (age at onset); LUSC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg17541715 chr7:1216824 NA -0.4 -6.23 -0.32 1.38e-9 Longevity;Endometriosis; LUSC cis rs7246967 0.673 rs118059742 chr19:22819446 T/A cg23217946 chr19:22817039 ZNF492 0.45 6.44 0.33 4.16e-10 Bronchopulmonary dysplasia; LUSC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg06238570 chr21:40685208 BRWD1 -0.6 -9.94 -0.48 1.48e-20 Cognitive function; LUSC cis rs2354432 0.607 rs6593751 chr1:146726023 A/G cg25205988 chr1:146714368 CHD1L -1.02 -9.34 -0.46 1.36e-18 Mitochondrial DNA levels; LUSC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.4 5.7 0.3 2.7e-8 Schizophrenia; LUSC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg13206674 chr6:150067644 NUP43 0.56 8.63 0.43 2.47e-16 Lung cancer; LUSC cis rs9359856 0.564 rs17228548 chr6:90439164 T/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.43 -0.42 1.02e-15 Bipolar disorder; LUSC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg04352962 chr1:209979756 IRF6 0.5 6.74 0.35 7.1e-11 Cleft lip with or without cleft palate; LUSC cis rs926938 0.563 rs360642 chr1:115425429 C/G cg01522456 chr1:115632236 TSPAN2 -0.4 -6.07 -0.32 3.53e-9 Autism; LUSC cis rs8031584 0.578 rs1088473 chr15:31139298 A/G cg08704250 chr15:31115839 NA 0.59 9.24 0.45 2.97e-18 Huntington's disease progression; LUSC cis rs7829975 0.591 rs12677543 chr8:8644274 G/C cg06636001 chr8:8085503 FLJ10661 0.61 9.39 0.46 9.56e-19 Mood instability; LUSC cis rs2354432 0.607 rs57078845 chr1:146722222 G/A cg25205988 chr1:146714368 CHD1L -1.02 -9.45 -0.46 6.3e-19 Mitochondrial DNA levels; LUSC cis rs7674212 0.570 rs1031804 chr4:104066049 C/T cg16532752 chr4:104119610 CENPE -0.48 -6.96 -0.36 1.83e-11 Type 2 diabetes; LUSC cis rs11650494 0.831 rs8065389 chr17:47456064 G/T cg08112188 chr17:47440006 ZNF652 -1.13 -10.27 -0.49 1.07e-21 Prostate cancer; LUSC cis rs4595586 0.525 rs1878227 chr12:39355719 A/T cg13010199 chr12:38710504 ALG10B 0.45 6.38 0.33 5.74e-10 Morning vs. evening chronotype; LUSC cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg08999081 chr20:33150536 PIGU 0.52 10.42 0.5 3.46e-22 Glomerular filtration rate (creatinine); LUSC cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg13319975 chr6:146136371 FBXO30 -0.5 -7.78 -0.39 9.36e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg18404041 chr3:52824283 ITIH1 -0.5 -9.53 -0.46 3.33e-19 Bipolar disorder; LUSC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg06634786 chr22:41940651 POLR3H -0.54 -6.33 -0.33 7.84e-10 Vitiligo; LUSC trans rs853679 0.546 rs17695758 chr6:27837183 T/C cg01620082 chr3:125678407 NA -0.82 -7.32 -0.37 1.84e-12 Depression; LUSC cis rs7833986 1.000 rs72654002 chr8:57095939 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.63 9.35 0.46 1.28e-18 Height; LUSC cis rs6582630 0.638 rs12231073 chr12:38526901 T/G cg26384229 chr12:38710491 ALG10B -0.57 -8.65 -0.43 2.17e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg06634786 chr22:41940651 POLR3H -0.53 -6.5 -0.34 2.86e-10 Vitiligo; LUSC cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg03878208 chr11:72483293 STARD10 0.46 6.88 0.35 2.9100000000000002e-11 Body mass index; LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg04518342 chr5:131593106 PDLIM4 0.48 8.82 0.43 6.41e-17 Blood metabolite levels; LUSC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg22535103 chr8:58192502 C8orf71 -0.73 -9.35 -0.46 1.32e-18 Developmental language disorder (linguistic errors); LUSC cis rs9443645 0.527 rs949846 chr6:79817596 C/T cg23262351 chr6:79576851 IRAK1BP1 -0.38 -5.73 -0.3 2.24e-8 Intelligence (multi-trait analysis); LUSC trans rs10085978 0.604 rs10099944 chr8:143234817 A/G cg10785443 chr2:219827728 NA 0.36 6.15 0.32 2.16e-9 Mosquito bite size; LUSC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg05425664 chr17:57184151 TRIM37 0.59 9.19 0.45 4.42e-18 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.97 0.44 2.22e-17 Prudent dietary pattern; LUSC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg06212747 chr3:49208901 KLHDC8B 0.43 5.81 0.3 1.43e-8 Parkinson's disease; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg01777103 chr8:145550585 DGAT1 0.37 6.21 0.32 1.56e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14498989 chr22:39268205 CBX6 -0.4 -5.98 -0.31 5.63e-9 Electrocardiographic conduction measures; LUSC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.49 0.46 4.39e-19 Bipolar disorder; LUSC trans rs9393777 0.778 rs35741362 chr6:27007687 T/C cg06606381 chr12:133084897 FBRSL1 -0.66 -7.13 -0.36 6.26e-12 Intelligence (multi-trait analysis); LUSC cis rs7202877 0.572 rs8051611 chr16:75388933 C/T cg04384234 chr16:75411784 CFDP1 -0.62 -8.71 -0.43 1.45e-16 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7106204 0.748 rs36092013 chr11:24211987 C/T ch.11.24196551F chr11:24239977 NA 1.13 12.76 0.57 1.21e-30 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7200543 1.000 rs4985154 chr16:15131642 G/C cg03427771 chr16:15082598 PDXDC1 -0.42 -5.88 -0.31 9.86e-9 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; LUSC cis rs708547 0.624 rs1718886 chr4:57849251 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.44 -6.6 -0.34 1.63e-10 Response to bleomycin (chromatid breaks); LUSC cis rs1371867 0.846 rs1788181 chr8:101334068 C/T cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.37e-11 Atrioventricular conduction; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg12191964 chr2:43823338 THADA -0.47 -7.83 -0.39 6.42e-14 Electrocardiographic conduction measures; LUSC cis rs16866061 1.000 rs72974267 chr2:225454209 T/C cg12698349 chr2:225449008 CUL3 0.87 14.49 0.62 2.96e-37 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg11812906 chr14:75593930 NEK9 0.66 11.37 0.53 1.55e-25 Height; LUSC trans rs4650994 0.544 rs6675811 chr1:178499068 T/A cg05059571 chr16:84539110 KIAA1609 -0.47 -9.14 -0.45 6.17e-18 HDL cholesterol levels;HDL cholesterol; LUSC cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg06108461 chr20:60628389 TAF4 -0.93 -15.59 -0.65 1.53e-41 Body mass index; LUSC cis rs2245008 0.774 rs253136 chr16:83979601 A/C cg07978099 chr16:83986941 OSGIN1 -0.43 -6.13 -0.32 2.53e-9 Pursuit maintenance gain; LUSC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg04850211 chr1:228464232 OBSCN 0.32 5.85 0.3 1.18e-8 Diastolic blood pressure; LUSC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.67 -9.51 -0.46 3.77e-19 Multiple sclerosis; LUSC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg00677455 chr12:58241039 CTDSP2 -0.6 -8.68 -0.43 1.77e-16 Multiple sclerosis; LUSC cis rs2219968 0.962 rs13254874 chr8:78944681 T/C cg00738934 chr8:78996279 NA 0.38 6.81 0.35 4.41e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg18402987 chr7:1209562 NA 0.73 7.92 0.4 3.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg17366294 chr4:99064904 C4orf37 0.56 9.95 0.48 1.33e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg13010199 chr12:38710504 ALG10B 0.65 9.81 0.47 3.95e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.58 -0.38 3.45e-13 Menopause (age at onset); LUSC cis rs9462027 0.506 rs6934662 chr6:34759884 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.32 -5.65 -0.3 3.37e-8 Systemic lupus erythematosus; LUSC cis rs12618769 0.656 rs3769735 chr2:99092302 C/T cg10123293 chr2:99228465 UNC50 0.42 7.0 0.36 1.4e-11 Bipolar disorder; LUSC cis rs7818345 0.613 rs13261732 chr8:19330215 T/C cg11303988 chr8:19266685 CSGALNACT1 0.34 6.04 0.31 4.16e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1595825 0.945 rs6756641 chr2:198849672 T/G cg10547527 chr2:198650123 BOLL -0.5 -6.13 -0.32 2.49e-9 Ulcerative colitis; LUSC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg06238570 chr21:40685208 BRWD1 -0.64 -10.72 -0.51 3.15e-23 Cognitive function; LUSC cis rs7267979 1.000 rs1047171 chr20:25428786 T/C cg03522245 chr20:25566470 NINL 0.35 5.67 0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7605827 0.930 rs2287273 chr2:15658523 T/C cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC trans rs62238980 0.614 rs17745543 chr22:32475456 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs79149102 0.579 rs2304904 chr15:75315975 G/A cg09165964 chr15:75287851 SCAMP5 -0.92 -8.05 -0.4 1.43e-14 Lung cancer; LUSC trans rs8073060 0.544 rs7210966 chr17:33986334 G/C cg19694781 chr19:47549865 TMEM160 -1.16 -18.43 -0.71 8.09e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg15691649 chr6:25882328 NA 0.51 7.58 0.38 3.4e-13 Blood metabolite levels; LUSC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.05e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg24842967 chr1:156084750 LMNA 0.48 6.0 0.31 5.22e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6503525 0.628 rs4065985 chr17:38101932 G/C cg17344932 chr17:38183730 MED24;SNORD124 -0.48 -7.79 -0.39 8.35e-14 Asthma; LUSC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg04369109 chr6:150039330 LATS1 -0.54 -7.97 -0.4 2.56e-14 Lung cancer; LUSC cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg13451222 chr11:65405525 SIPA1 0.45 5.65 0.3 3.35e-8 Blood pressure (age interaction); LUSC cis rs2854207 0.505 rs2466957 chr17:61961230 G/C cg11494091 chr17:61959527 GH2 0.38 6.21 0.32 1.59e-9 Height; LUSC cis rs2445762 0.659 rs17524318 chr15:51663386 G/A cg07517944 chr15:51633816 GLDN 0.37 6.23 0.32 1.39e-9 Hormone measurements; LUSC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg00945038 chr17:61921165 SMARCD2 0.54 9.45 0.46 6.03e-19 Prudent dietary pattern; LUSC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg16479474 chr6:28041457 NA 0.32 5.72 0.3 2.31e-8 Parkinson's disease; LUSC cis rs4766566 0.651 rs933306 chr12:111737985 A/T cg10833066 chr12:111807467 FAM109A 0.56 10.62 0.5 6.88e-23 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; LUSC cis rs12760731 0.720 rs16852801 chr1:178403134 A/T cg00404053 chr1:178313656 RASAL2 -0.57 -6.21 -0.32 1.53e-9 Obesity-related traits; LUSC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg20933634 chr6:27740509 NA 0.42 6.03 0.31 4.38e-9 Parkinson's disease; LUSC cis rs9393692 0.645 rs28446029 chr6:26305801 C/G cg00631329 chr6:26305371 NA -0.56 -10.78 -0.51 1.85e-23 Educational attainment; LUSC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg23034840 chr1:205782522 SLC41A1 0.67 9.97 0.48 1.17e-20 Menarche (age at onset); LUSC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg05623727 chr3:50126028 RBM5 -0.37 -6.86 -0.35 3.31e-11 Body mass index; LUSC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg22433210 chr17:43662623 NA 0.75 10.89 0.51 7.94e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6484504 0.625 rs6484501 chr11:31373100 G/T cg06552810 chr11:31128660 NA 0.39 6.77 0.35 5.78e-11 Red blood cell count; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08118159 chr19:41055208 SPTBN4 -0.43 -6.41 -0.33 5.1e-10 Electrocardiographic conduction measures; LUSC cis rs7617773 0.780 rs2541 chr3:48339618 A/G cg11946769 chr3:48343235 NME6 0.88 14.29 0.62 1.69e-36 Coronary artery disease; LUSC cis rs7091068 0.566 rs7098349 chr10:95514907 A/C cg20715218 chr10:95462985 C10orf4 0.63 6.93 0.35 2.23e-11 Urinary tract infection frequency; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg14893161 chr1:205819251 PM20D1 0.78 14.05 0.61 1.44e-35 Menarche (age at onset); LUSC cis rs10771431 0.597 rs10843142 chr12:9357502 A/G cg08997352 chr12:9597637 DDX12 -0.7 -11.04 -0.52 2.33e-24 Breast size; LUSC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg08888203 chr3:10149979 C3orf24 -0.44 -6.87 -0.35 3.15e-11 Alzheimer's disease; LUSC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg21724239 chr8:58056113 NA 0.55 6.37 0.33 6.1e-10 Developmental language disorder (linguistic errors); LUSC cis rs8114671 0.933 rs2103971 chr20:33786256 T/C cg07148914 chr20:33460835 GGT7 -0.44 -6.42 -0.33 4.59e-10 Height; LUSC cis rs9653442 0.527 rs10176782 chr2:100782827 C/A cg22139774 chr2:100720529 AFF3 -0.41 -7.12 -0.36 6.51e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg24250549 chr1:154909240 PMVK 0.64 10.53 0.5 1.42e-22 Prostate cancer; LUSC cis rs1348850 0.958 rs10497501 chr2:178462299 C/G cg22681709 chr2:178499509 PDE11A -0.47 -8.55 -0.42 4.39e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs72781680 1.000 rs72781675 chr2:24232092 G/A cg20701182 chr2:24300061 SF3B14 0.75 7.62 0.38 2.73e-13 Lymphocyte counts; LUSC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -11.59 -0.54 2.5e-26 Schizophrenia; LUSC cis rs2364543 0.624 rs61774752 chr1:41847024 T/C cg08462924 chr1:41848221 NA 0.49 8.26 0.41 3.52e-15 Intelligence (multi-trait analysis); LUSC cis rs3540 0.597 rs1978151 chr15:91037300 C/T cg10434728 chr15:90938212 IQGAP1 0.46 9.18 0.45 4.48e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg00339695 chr16:24857497 SLC5A11 0.61 9.57 0.46 2.45e-19 Intelligence (multi-trait analysis); LUSC trans rs9944715 0.911 rs12969147 chr18:43806524 G/A cg01718231 chr17:29326311 RNF135 -0.5 -7.04 -0.36 1.13e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7246657 1.000 rs10426297 chr19:37798373 A/G cg23950597 chr19:37808831 NA -0.64 -7.47 -0.38 6.98e-13 Coronary artery calcification; LUSC cis rs17255340 0.581 rs9449616 chr6:84100190 G/A cg08257003 chr6:84140564 ME1 0.35 8.64 0.43 2.3e-16 Platelet-derived growth factor BB levels; LUSC cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.16 0.32 2.1e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs7829975 0.564 rs2921060 chr8:8317817 G/T cg21775007 chr8:11205619 TDH -0.42 -6.16 -0.32 2.06e-9 Mood instability; LUSC cis rs4631830 0.863 rs2611507 chr10:51518673 T/C cg16070123 chr10:51489643 NA -0.5 -7.95 -0.4 2.85e-14 Prostate-specific antigen levels; LUSC cis rs752092 1.000 rs752092 chr15:101781934 C/T cg19997662 chr15:101784653 CHSY1 0.41 6.13 0.32 2.43e-9 Corneal structure; LUSC trans rs61931739 0.500 rs7306334 chr12:34482900 A/G cg26384229 chr12:38710491 ALG10B -0.89 -15.42 -0.64 6.78e-41 Morning vs. evening chronotype; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.52 6.51 0.34 2.72e-10 Renal function-related traits (BUN); LUSC cis rs478304 0.627 rs11604568 chr11:65511336 G/A cg10604040 chr11:65559109 OVOL1 0.32 5.85 0.3 1.18e-8 Acne (severe); LUSC cis rs9467711 0.606 rs13190739 chr6:26587373 G/T cg09904177 chr6:26538194 HMGN4 -0.75 -5.79 -0.3 1.63e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.08 0.48 5.06e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg01097406 chr16:89675127 NA 0.49 9.99 0.48 9.77e-21 Vitiligo; LUSC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg12560992 chr17:57184187 TRIM37 0.9 17.24 0.69 4.15e-48 Intelligence (multi-trait analysis); LUSC cis rs524023 0.914 rs2666559 chr11:64439227 G/T cg19131476 chr11:64387923 NRXN2 -0.22 -5.73 -0.3 2.24e-8 Urate levels in obese individuals; LUSC cis rs3820928 0.874 rs10176882 chr2:227896432 A/T cg11843606 chr2:227700838 RHBDD1 -0.49 -7.09 -0.36 7.98e-12 Pulmonary function; LUSC cis rs9309473 0.607 rs7574291 chr2:73594941 A/G cg20560298 chr2:73613845 ALMS1 -0.56 -8.19 -0.41 5.58e-15 Metabolite levels; LUSC cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg02454025 chr1:11042201 C1orf127 1.0 18.69 0.72 7.18e-54 Ewing sarcoma; LUSC cis rs7107174 1.000 rs10793297 chr11:78009660 T/C cg02023728 chr11:77925099 USP35 0.49 6.88 0.35 3.02e-11 Testicular germ cell tumor; LUSC cis rs1577917 0.958 rs114467802 chr6:86572350 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.68 -0.43 1.76e-16 Response to antipsychotic treatment; LUSC trans rs10435719 0.899 rs9329251 chr8:11793606 G/A cg08975724 chr8:8085496 FLJ10661 0.48 6.96 0.36 1.79e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg20503657 chr10:835505 NA 1.0 14.36 0.62 9.12e-37 Eosinophil percentage of granulocytes; LUSC trans rs747782 0.527 rs7129364 chr11:48150576 G/A cg03929089 chr4:120376271 NA 0.72 6.5 0.34 2.99e-10 Intraocular pressure; LUSC cis rs7258465 0.931 rs875396 chr19:18611147 A/G cg06462663 chr19:18546047 ISYNA1 0.49 8.25 0.41 3.6e-15 Breast cancer; LUSC cis rs2932538 0.922 rs34531155 chr1:113141550 C/T cg22162597 chr1:113214053 CAPZA1 0.7 10.02 0.48 8.03e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg21400344 chr1:25870172 LDLRAP1 0.37 6.34 0.33 7.53e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.7 -0.34 8.72e-11 Tonsillectomy; LUSC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg06915202 chr7:98029285 BAIAP2L1 -0.32 -6.32 -0.33 8.51e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs4423214 1.000 rs12792306 chr11:71166992 T/C cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.38e-24 Vitamin D levels; LUSC cis rs7216064 0.589 rs7213585 chr17:66062316 A/T cg12091567 chr17:66097778 LOC651250 -0.91 -14.61 -0.62 9.66e-38 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs2599510 0.748 rs6718214 chr2:32550485 T/C cg02381751 chr2:32503542 YIPF4 -0.39 -5.77 -0.3 1.78e-8 Interleukin-18 levels; LUSC cis rs12310956 0.515 rs1852221 chr12:33945489 G/T cg06521331 chr12:34319734 NA -0.48 -7.72 -0.39 1.33e-13 Morning vs. evening chronotype; LUSC cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg08873628 chr1:175162347 KIAA0040 0.39 5.75 0.3 2.06e-8 Alcohol dependence; LUSC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg03732007 chr1:2071316 PRKCZ -0.6 -11.1 -0.52 1.36e-24 Height; LUSC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg11766577 chr21:47581405 C21orf56 -0.42 -6.35 -0.33 6.99e-10 Testicular germ cell tumor; LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg01657329 chr11:68192670 LRP5 -0.45 -7.13 -0.36 6.28e-12 Total body bone mineral density; LUSC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg03609598 chr5:56110824 MAP3K1 -0.43 -6.3 -0.33 9.51e-10 Initial pursuit acceleration; LUSC cis rs9905704 0.624 rs8080071 chr17:57093825 C/T cg12560992 chr17:57184187 TRIM37 -0.64 -10.63 -0.5 6.36e-23 Testicular germ cell tumor; LUSC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg13770153 chr20:60521292 NA -0.45 -6.52 -0.34 2.56e-10 Body mass index; LUSC trans rs11098499 1.000 rs12506395 chr4:120185094 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.44 6.02 0.31 4.68e-9 Corneal astigmatism; LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.01 13.39 0.59 4.9e-33 Platelet count; LUSC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg12639453 chr1:2035780 PRKCZ 0.31 6.71 0.34 8.1e-11 Height; LUSC trans rs62458065 0.513 rs10268149 chr7:32575499 T/C cg00845942 chr12:64062724 DPY19L2 -0.62 -7.87 -0.4 5.15e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs6500395 0.962 rs9937134 chr16:48577683 T/A cg04672837 chr16:48644449 N4BP1 0.43 6.28 0.32 1.05e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6598955 0.671 rs11247908 chr1:26638222 G/A cg00852783 chr1:26633632 UBXN11 -0.51 -5.82 -0.3 1.37e-8 Obesity-related traits; LUSC cis rs11997175 0.550 rs7459534 chr8:33836623 G/C ch.8.33884649F chr8:33765107 NA 0.38 5.91 0.31 8.51e-9 Body mass index; LUSC cis rs1335645 0.570 rs67493833 chr1:111649241 A/T cg00321911 chr1:111669324 DRAM2 -0.56 -6.0 -0.31 5.01e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg22681709 chr2:178499509 PDE11A -0.52 -9.18 -0.45 4.74e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7568458 0.783 rs2166529 chr2:85742175 A/C cg17127132 chr2:85788382 GGCX -0.43 -6.7 -0.34 8.95e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC trans rs867371 0.762 rs12905578 chr15:82581264 T/G cg18393722 chr15:85113863 UBE2QP1 0.48 7.02 0.36 1.24e-11 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9393777 0.623 rs9358947 chr6:26479000 G/A cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC cis rs7615952 0.673 rs16834637 chr3:125605471 C/T cg05084668 chr3:125655381 ALG1L -0.83 -11.74 -0.54 6.94e-27 Blood pressure (smoking interaction); LUSC trans rs6828577 0.862 rs298994 chr4:119627253 A/G cg26518628 chr1:97050305 NA 0.41 5.96 0.31 6.58e-9 Perioperative myocardial infarction in coronary artery bypass surgery; LUSC trans rs1035275 0.507 rs17664296 chr3:64148288 C/T cg13925011 chr1:111216387 KCNA3 -0.31 -6.13 -0.32 2.45e-9 IgG glycosylation; LUSC cis rs11148252 0.574 rs7139495 chr13:53283318 A/G cg00495681 chr13:53174319 NA 0.79 15.07 0.64 1.65e-39 Lewy body disease; LUSC cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg26395211 chr5:140044315 WDR55 -0.39 -5.98 -0.31 5.86e-9 Depressive symptoms (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg03602528 chr17:19266095 B9D1 -0.4 -5.98 -0.31 5.88e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6570726 1.000 rs373778 chr6:145873252 C/T cg23711669 chr6:146136114 FBXO30 0.74 12.93 0.58 2.73e-31 Lobe attachment (rater-scored or self-reported); LUSC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg07870213 chr5:140052090 DND1 0.79 11.66 0.54 1.33e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03352830 chr11:487213 PTDSS2 0.69 8.67 0.43 1.9e-16 Body mass index; LUSC cis rs7954584 0.635 rs7309024 chr12:122338334 C/T cg22618164 chr12:122356400 WDR66 0.58 8.71 0.43 1.42e-16 Mean corpuscular volume; LUSC cis rs9650315 0.866 rs34114399 chr8:57166135 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.48 6.83 0.35 3.91e-11 Height; LUSC cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg27279351 chr12:120934652 DYNLL1 0.64 8.6 0.43 3.09e-16 High light scatter reticulocyte count; LUSC trans rs11039798 0.925 rs10769373 chr11:48531980 T/A cg03929089 chr4:120376271 NA 0.66 6.18 0.32 1.86e-9 Axial length; LUSC cis rs11098499 0.866 rs13105020 chr4:120285688 G/T cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs7512552 0.773 rs3737240 chr1:150483355 C/T cg15654264 chr1:150340011 RPRD2 0.61 9.6 0.47 1.98e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs4243830 0.850 rs10746502 chr1:6607199 A/G cg05709478 chr1:6581295 PLEKHG5 -0.47 -5.7 -0.3 2.59e-8 Body mass index; LUSC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg16743903 chr16:89593216 SPG7 -0.37 -5.81 -0.3 1.44e-8 Multiple myeloma (IgH translocation); LUSC cis rs10992471 0.756 rs7043152 chr9:95138499 A/G cg14631576 chr9:95140430 CENPP -0.33 -5.94 -0.31 7.09e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs10504229 0.636 rs114725691 chr8:58054292 C/T cg11062466 chr8:58055876 NA 0.53 6.94 0.36 2.01e-11 Developmental language disorder (linguistic errors); LUSC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg02675527 chr2:114030824 PAX8;LOC440839 -0.58 -9.29 -0.45 2.05e-18 Lymphocyte counts; LUSC trans rs72792513 1.000 rs58611583 chr2:22881278 A/G cg05844895 chr16:88969569 CBFA2T3 0.52 6.2 0.32 1.63e-9 Hepatitis B; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00039044 chr4:83351858 ENOPH1;HNRPDL -0.41 -6.0 -0.31 5.25e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg06627557 chr7:32535165 LSM5;AVL9 1.07 20.81 0.75 2.88e-62 Cognitive ability; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg18099408 chr3:52552593 STAB1 -0.41 -7.03 -0.36 1.2e-11 Bipolar disorder; LUSC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg08798685 chr6:27730294 NA -0.63 -5.99 -0.31 5.39e-9 Breast cancer; LUSC cis rs7605827 0.897 rs6745621 chr2:15537866 C/A cg19274914 chr2:15703543 NA 0.46 8.99 0.44 1.88e-17 Educational attainment (years of education); LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg22638593 chr5:131593259 PDLIM4 0.42 6.09 0.32 3.17e-9 Breast cancer; LUSC trans rs7824557 0.628 rs6601580 chr8:11193736 T/G cg06636001 chr8:8085503 FLJ10661 0.43 6.34 0.33 7.37e-10 Retinal vascular caliber; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg04025307 chr7:1156635 C7orf50 0.54 8.63 0.43 2.52e-16 Longevity;Endometriosis; LUSC cis rs354225 0.544 rs10170355 chr2:54808322 G/A cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs7582180 0.681 rs6754176 chr2:100995691 C/T cg08017756 chr2:100939284 LONRF2 -0.4 -7.4 -0.38 1.1e-12 Intelligence (multi-trait analysis); LUSC trans rs1325195 0.839 rs2816189 chr1:179136269 G/C cg11624085 chr17:8464688 MYH10 0.41 6.66 0.34 1.1e-10 IgE grass sensitization; LUSC cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg12365402 chr11:9010492 NRIP3 0.45 8.33 0.41 2.16e-15 Hemoglobin concentration; LUSC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg19346786 chr7:2764209 NA -0.48 -8.05 -0.4 1.44e-14 Height; LUSC cis rs8060686 0.641 rs12448677 chr16:68209741 G/A cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs55794721 0.509 rs6699896 chr1:25762902 A/T cg27572855 chr1:25598939 RHD 0.46 8.19 0.41 5.51e-15 Plateletcrit;Mean corpuscular volume; LUSC cis rs9486715 0.867 rs9386500 chr6:96889845 A/C cg06623918 chr6:96969491 KIAA0776 0.94 17.57 0.69 2.11e-49 Headache; LUSC cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg10172584 chr19:19639581 YJEFN3 -0.48 -5.77 -0.3 1.85e-8 Bipolar disorder; LUSC cis rs6429082 0.818 rs291381 chr1:235641924 A/G cg26050004 chr1:235667680 B3GALNT2 0.6 8.27 0.41 3.29e-15 Adiposity; LUSC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.6e-11 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02608231 chr3:47844363 DHX30 -0.44 -6.69 -0.34 9.42e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg06636001 chr8:8085503 FLJ10661 0.58 8.43 0.42 1.02e-15 Mean corpuscular volume; LUSC cis rs7246967 0.673 rs7248107 chr19:22878529 G/T cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC trans rs62126824 0.570 rs1370692 chr2:23620014 C/T cg15896939 chr1:156030809 RAB25 0.42 6.07 0.32 3.43e-9 Night sleep phenotypes; LUSC cis rs3741151 1.000 rs112628073 chr11:73013626 C/T cg17517138 chr11:73019481 ARHGEF17 1.13 9.23 0.45 3.13e-18 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs12519773 0.555 rs2578490 chr5:92389236 C/T cg18783429 chr5:92414398 NA 0.33 7.1 0.36 7.74e-12 Migraine; LUSC cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.27 0.41 3.21e-15 Menarche (age at onset); LUSC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs1448094 0.967 rs7961782 chr12:86326461 T/C cg02569458 chr12:86230093 RASSF9 0.42 6.86 0.35 3.31e-11 Major depressive disorder; LUSC cis rs983392 0.679 rs611418 chr11:60011013 C/T cg20284999 chr11:59952153 MS4A6A 0.38 6.33 0.33 7.75e-10 Alzheimer's disease (late onset); LUSC cis rs78663649 1.000 rs78663649 chr19:16489447 C/T cg05286348 chr19:16641544 CHERP -0.6 -5.78 -0.3 1.73e-8 White blood cell count; LUSC cis rs354225 0.546 rs10170646 chr2:54799606 T/C cg26097391 chr2:54893211 SPTBN1 0.39 6.31 0.33 8.74e-10 Schizophrenia; LUSC cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg11871910 chr12:69753446 YEATS4 0.65 10.05 0.48 6e-21 Blood protein levels; LUSC cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg08999081 chr20:33150536 PIGU -0.54 -10.85 -0.51 1.09e-23 Glomerular filtration rate (creatinine); LUSC trans rs7786808 0.552 rs896762 chr7:158182029 A/G cg02030672 chr11:45687055 CHST1 -0.49 -7.87 -0.4 5.01e-14 Obesity-related traits; LUSC cis rs314370 0.951 rs17884589 chr7:100493711 G/A cg10426581 chr7:100472382 SRRT 0.86 12.33 0.56 4.67e-29 Resting heart rate; LUSC cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6500602 0.679 rs736685 chr16:4508606 T/C cg08645402 chr16:4508243 NA 0.56 9.77 0.47 5.45e-20 Schizophrenia; LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg19303637 chr13:24153954 TNFRSF19 0.35 6.06 0.31 3.65e-9 Major depressive disorder; LUSC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg13119609 chr19:45449297 APOC2 0.47 9.46 0.46 5.65e-19 Blood protein levels; LUSC cis rs7216064 1.000 rs7212293 chr17:65847325 A/G cg12091567 chr17:66097778 LOC651250 -0.73 -9.63 -0.47 1.6e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs6087990 0.735 rs2424928 chr20:31388636 T/C cg13636640 chr20:31349939 DNMT3B 0.92 18.94 0.72 7.43e-55 Ulcerative colitis; LUSC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg15534755 chr11:117069859 TAGLN 0.35 5.74 0.3 2.18e-8 Blood protein levels; LUSC cis rs1178968 0.901 rs799303 chr7:72804412 A/C cg25889504 chr7:72793014 NA -0.64 -8.47 -0.42 7.91e-16 Triglyceride levels; LUSC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg03538708 chr1:25844672 NA -0.36 -5.84 -0.3 1.22e-8 Erythrocyte sedimentation rate; LUSC cis rs6967385 0.560 rs34130399 chr7:12356746 T/A cg06484146 chr7:12443880 VWDE 0.5 7.51 0.38 5.42e-13 Response to taxane treatment (placlitaxel); LUSC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg11062466 chr8:58055876 NA 0.51 6.96 0.36 1.84e-11 Developmental language disorder (linguistic errors); LUSC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg26769984 chr7:1090371 C7orf50 0.66 8.74 0.43 1.17e-16 Bronchopulmonary dysplasia; LUSC cis rs9911578 0.867 rs4793941 chr17:56472366 G/A cg05425664 chr17:57184151 TRIM37 0.54 8.6 0.43 3.07e-16 Intelligence (multi-trait analysis); LUSC cis rs11168618 0.935 rs2114322 chr12:48951607 A/G cg24011408 chr12:48396354 COL2A1 -0.37 -6.04 -0.31 4.13e-9 Adiponectin levels; LUSC cis rs7264396 0.887 rs224362 chr20:34062642 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -5.93 -0.31 7.69e-9 Total cholesterol levels; LUSC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg00343127 chr12:129299088 SLC15A4;MGC16384 0.35 5.65 0.3 3.47e-8 Systemic lupus erythematosus; LUSC cis rs477692 0.569 rs10764882 chr10:131306496 C/G cg05714579 chr10:131428358 MGMT 0.41 5.75 0.3 2.06e-8 Response to temozolomide; LUSC trans rs11088226 0.681 rs2833926 chr21:33975279 A/G cg09050820 chr6:167586206 TCP10L2 0.72 9.39 0.46 9.58e-19 Gastritis; LUSC cis rs1003719 0.788 rs2835576 chr21:38457393 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.46 0.53 7.16e-26 Eye color traits; LUSC cis rs7017697 1.000 rs10092772 chr8:19686385 A/T cg03894339 chr8:19674705 INTS10 -0.46 -6.72 -0.34 7.99e-11 Breast cancer; LUSC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg16680214 chr1:154839983 KCNN3 -0.52 -9.76 -0.47 5.77e-20 Prostate cancer; LUSC cis rs9300255 0.568 rs1727300 chr12:123664205 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.34 -0.33 7.25e-10 Neutrophil percentage of white cells; LUSC cis rs6547741 1.000 rs1528404 chr2:27846603 C/T cg12559939 chr2:27858050 GPN1 -0.41 -6.34 -0.33 7.36e-10 Oral cavity cancer; LUSC trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg03929089 chr4:120376271 NA 0.69 7.78 0.39 9.14e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs684232 0.666 rs423887 chr17:593600 A/G cg15660573 chr17:549704 VPS53 -0.68 -10.31 -0.49 7.98e-22 Prostate cancer; LUSC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg09517075 chr8:22133004 PIWIL2 0.43 8.9 0.44 3.61e-17 Hypertriglyceridemia; LUSC cis rs9361491 0.657 rs9343804 chr6:79468052 G/A cg05283184 chr6:79620031 NA -0.31 -5.66 -0.3 3.22e-8 Intelligence (multi-trait analysis); LUSC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg00784671 chr22:46762841 CELSR1 -0.49 -6.42 -0.33 4.56e-10 LDL cholesterol;Cholesterol, total; LUSC trans rs629535 0.699 rs539956 chr8:70033647 G/A cg21567404 chr3:27674614 NA 0.95 14.3 0.62 1.54e-36 Dupuytren's disease; LUSC cis rs9400467 0.592 rs462493 chr6:111683740 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs1023500 0.551 rs133355 chr22:42440285 G/A cg04733989 chr22:42467013 NAGA 0.62 9.64 0.47 1.48e-19 Schizophrenia; LUSC cis rs116095464 1.000 rs28416084 chr5:217640 G/A cg22857025 chr5:266934 NA -1.18 -14.3 -0.62 1.62e-36 Breast cancer; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg21099776 chr17:17739742 SREBF1 -0.42 -6.22 -0.32 1.52e-9 Hepatitis; LUSC cis rs7617480 0.648 rs9864243 chr3:48982732 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.65 9.75 0.47 6.45e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs10193935 1.000 rs58962161 chr2:42400278 T/A cg27598129 chr2:42591480 NA -0.55 -7.56 -0.38 3.91e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -12.21 -0.56 1.35e-28 Chronic sinus infection; LUSC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg11905131 chr22:24372483 LOC391322 -0.42 -6.89 -0.35 2.75e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg01689657 chr7:91764605 CYP51A1 -0.34 -6.26 -0.32 1.19e-9 Breast cancer; LUSC cis rs1712517 0.503 rs72846198 chr10:105098024 G/A cg04362960 chr10:104952993 NT5C2 -0.52 -6.95 -0.36 1.89e-11 Migraine; LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg02931644 chr1:25747376 RHCE 0.38 7.07 0.36 9.08e-12 Erythrocyte sedimentation rate; LUSC cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg03146154 chr1:46216737 IPP -0.51 -7.73 -0.39 1.3e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.58 -0.5 9.41e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg26695010 chr11:65641043 EFEMP2 -0.46 -7.01 -0.36 1.32e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC trans rs17169634 1.000 rs6950651 chr7:34076802 A/C cg18512313 chr14:70700886 NA 0.61 6.25 0.32 1.29e-9 Alzheimer's disease; LUSC cis rs4654899 0.833 rs10916919 chr1:21317524 A/G cg01072550 chr1:21505969 NA 0.53 8.02 0.4 1.85e-14 Superior frontal gyrus grey matter volume; LUSC cis rs9467160 0.734 rs9467170 chr6:24452754 G/A cg20631270 chr6:24437470 GPLD1 0.41 5.66 0.3 3.24e-8 Liver enzyme levels; LUSC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg10909506 chr17:38081995 ORMDL3 0.35 6.22 0.32 1.45e-9 Self-reported allergy; LUSC cis rs4363385 0.740 rs4845518 chr1:153003903 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -5.71 -0.3 2.45e-8 Inflammatory skin disease; LUSC cis rs75920871 0.528 rs3886960 chr11:116924990 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.42 -0.33 4.69e-10 Subjective well-being; LUSC cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg01802117 chr1:53393560 SCP2 0.39 6.46 0.33 3.72e-10 Monocyte count; LUSC cis rs7927592 0.956 rs55816191 chr11:68262979 G/T cg20283391 chr11:68216788 NA -0.58 -8.17 -0.41 6.64e-15 Total body bone mineral density; LUSC cis rs11758351 0.929 rs6906367 chr6:26187125 C/T cg01420254 chr6:26195488 NA 0.51 6.3 0.33 9.56e-10 Gout;Renal underexcretion gout; LUSC cis rs2762353 0.935 rs1165196 chr6:25813150 A/G cg03264133 chr6:25882463 NA 0.43 7.49 0.38 6.03e-13 Blood metabolite levels; LUSC cis rs6840360 0.615 rs12647616 chr4:152607662 G/A cg22705602 chr4:152727874 NA -0.37 -7.97 -0.4 2.51e-14 Intelligence (multi-trait analysis); LUSC cis rs73206853 0.841 rs2339511 chr12:110789372 C/T cg12870014 chr12:110450643 ANKRD13A 0.59 6.6 0.34 1.58e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC trans rs7618501 0.603 rs72942333 chr3:49986118 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.59 9.47 0.46 5.4e-19 Intelligence (multi-trait analysis); LUSC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 7.04 0.36 1.07e-11 Multiple sclerosis; LUSC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg03240473 chr21:43526662 UMODL1;C21orf128 -0.45 -7.17 -0.37 4.77e-12 IgG glycosylation; LUSC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg02782426 chr3:40428986 ENTPD3 -0.32 -5.76 -0.3 1.96e-8 Renal cell carcinoma; LUSC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg03526776 chr6:41159608 TREML2 0.47 8.71 0.43 1.39e-16 Alzheimer's disease (late onset); LUSC cis rs2073300 1.000 rs6137959 chr20:23442640 T/C cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs981844 0.714 rs6853529 chr4:154706267 C/T cg14289246 chr4:154710475 SFRP2 0.53 7.31 0.37 1.93e-12 Response to statins (LDL cholesterol change); LUSC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.8 -0.39 8.06e-14 Height; LUSC cis rs7715806 0.500 rs3797581 chr5:75002895 G/T cg19683494 chr5:74908142 NA 0.55 7.51 0.38 5.54e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3106136 0.546 rs2664880 chr4:95144177 T/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -8.59 -0.43 3.3e-16 Capecitabine sensitivity; LUSC cis rs7582180 0.663 rs4850930 chr2:100990955 T/C cg08017756 chr2:100939284 LONRF2 -0.41 -7.64 -0.39 2.38e-13 Intelligence (multi-trait analysis); LUSC cis rs1256061 0.603 rs1256039 chr14:64738979 G/C cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs4845459 0.967 rs1886734 chr1:152591142 A/C cg08895932 chr1:152778580 LCE1C -0.36 -6.3 -0.33 9.62e-10 Psoriasis; LUSC cis rs7408868 0.656 rs1043997 chr19:15292437 T/C cg14696996 chr19:15285081 NOTCH3 0.63 6.71 0.34 8.55e-11 Pulse pressure; LUSC cis rs6977660 1.000 rs12666159 chr7:19804199 T/C cg05791153 chr7:19748676 TWISTNB 0.55 6.19 0.32 1.72e-9 Thyroid stimulating hormone; LUSC cis rs11764590 0.694 rs10241537 chr7:2083358 A/G cg19629631 chr7:2060116 MAD1L1 -0.35 -5.76 -0.3 1.95e-8 Neuroticism; LUSC cis rs2816062 1.000 rs2816062 chr1:18903902 G/A cg18795169 chr1:18902165 NA -0.9 -18.23 -0.71 4.98e-52 Urate levels in lean individuals; LUSC trans rs2980439 0.870 rs2945230 chr8:8109936 A/G cg21775007 chr8:11205619 TDH 0.49 6.84 0.35 3.71e-11 Neuroticism; LUSC trans rs2204008 0.623 rs1607878 chr12:38376000 A/G cg06521331 chr12:34319734 NA -0.4 -6.25 -0.32 1.28e-9 Bladder cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg07444005 chr13:21678461 NA 0.58 8.24 0.41 3.97e-15 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -7.11 -0.36 7.27e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs60154123 0.772 rs701944 chr1:210417098 G/A cg22029157 chr1:209979665 IRF6 0.64 6.47 0.33 3.59e-10 Coronary artery disease; LUSC cis rs34779708 0.966 rs878264 chr10:35440581 T/C cg03585969 chr10:35415529 CREM 0.6 8.98 0.44 1.95e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs877282 0.945 rs10904554 chr10:786768 T/C cg13042288 chr15:90349979 ANPEP -0.46 -6.6 -0.34 1.63e-10 Uric acid levels; LUSC cis rs11098499 0.644 rs3986377 chr4:120260270 G/A cg09307838 chr4:120376055 NA 0.65 9.84 0.47 3.09e-20 Corneal astigmatism; LUSC cis rs1865760 0.534 rs72834629 chr6:26023032 C/T cg17691542 chr6:26056736 HIST1H1C 0.63 8.8 0.43 7.64e-17 Height; LUSC trans rs12145833 0.596 rs12026068 chr1:243440352 A/G cg01826367 chr1:224180288 NA 0.63 5.95 0.31 6.62e-9 Obesity (early onset extreme); LUSC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg08975724 chr8:8085496 FLJ10661 0.49 7.28 0.37 2.45e-12 Mood instability; LUSC cis rs4919687 0.550 rs11191372 chr10:104462187 T/C cg05855489 chr10:104503620 C10orf26 0.71 11.56 0.53 3.16e-26 Colorectal cancer; LUSC cis rs7572733 0.534 rs7572123 chr2:198769637 A/G cg00792783 chr2:198669748 PLCL1 0.46 6.2 0.32 1.68e-9 Dermatomyositis; LUSC cis rs897080 0.552 rs1067320 chr2:44633122 A/G cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg25251562 chr2:3704773 ALLC -0.49 -7.52 -0.38 5.1e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg25282410 chr6:160211355 TCP1;MRPL18 1.09 15.87 0.66 1.14e-42 Age-related macular degeneration (geographic atrophy); LUSC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg19717773 chr7:2847554 GNA12 -0.39 -6.43 -0.33 4.34e-10 Height; LUSC cis rs1018836 0.923 rs756569 chr8:91610957 G/A cg16814680 chr8:91681699 NA -0.77 -12.85 -0.58 5.65e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs929354 0.772 rs10230895 chr7:157007038 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.04 0.58 1.07e-31 Body mass index; LUSC cis rs7590368 0.715 rs72779474 chr2:10965980 G/A cg15705551 chr2:10952987 PDIA6 0.61 6.68 0.34 1.01e-10 Educational attainment (years of education); LUSC cis rs2692947 0.666 rs7566050 chr2:96626030 T/C cg23100626 chr2:96804247 ASTL 0.26 6.26 0.32 1.2e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg03929089 chr4:120376271 NA -1.04 -20.21 -0.74 7.12e-60 Height; LUSC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg22467129 chr15:76604101 ETFA -0.44 -7.05 -0.36 1.06e-11 Blood metabolite levels; LUSC cis rs5769707 0.542 rs739242 chr22:50057116 A/G cg20744362 chr22:50050164 C22orf34 0.36 6.54 0.34 2.33e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2274273 0.870 rs11851169 chr14:55815932 G/A cg04306507 chr14:55594613 LGALS3 0.53 11.62 0.54 1.95e-26 Protein biomarker; LUSC cis rs950776 0.616 rs3743077 chr15:78894896 C/T cg06917634 chr15:78832804 PSMA4 0.75 12.65 0.57 3.07e-30 Sudden cardiac arrest; LUSC cis rs9513627 0.915 rs73556174 chr13:100121797 T/C cg25919922 chr13:100150906 NA -0.8 -6.96 -0.36 1.83e-11 Obesity-related traits; LUSC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg17279839 chr7:150038598 RARRES2 0.54 7.89 0.4 4.38e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.42 0.5 3.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg05717871 chr11:638507 DRD4 -0.34 -5.9 -0.31 8.74e-9 Systemic lupus erythematosus; LUSC cis rs56283067 0.847 rs1552196 chr6:44698265 A/G cg20913747 chr6:44695427 NA 0.43 6.87 0.35 3.08e-11 Total body bone mineral density; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg18758796 chr5:131593413 PDLIM4 0.38 6.67 0.34 1.06e-10 Blood metabolite levels; LUSC trans rs1532331 0.898 rs10075647 chr5:43149499 C/T cg17870909 chr21:47566968 FTCD 0.26 6.13 0.32 2.51e-9 Menarche (age at onset); LUSC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg07414643 chr4:187882934 NA 0.54 9.87 0.48 2.56e-20 Lobe attachment (rater-scored or self-reported); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg14577476 chr17:49337432 MBTD1;UTP18 -0.37 -6.32 -0.33 8.53e-10 Electrocardiographic conduction measures; LUSC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.53 6.86 0.35 3.3e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs1577917 0.682 rs6935918 chr6:86283575 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 9.24 0.45 3.06e-18 Response to antipsychotic treatment; LUSC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg05368731 chr17:41323189 NBR1 0.9 13.47 0.59 2.53e-33 Menopause (age at onset); LUSC trans rs877282 0.583 rs11253428 chr10:823233 C/T cg22713356 chr15:30763199 NA 0.75 9.37 0.46 1.12e-18 Uric acid levels; LUSC trans rs953492 0.644 rs3896337 chr1:243414066 C/T cg25284624 chr1:224180302 NA -0.44 -6.73 -0.35 7.41e-11 Diastolic blood pressure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08081407 chr3:57583693 ARF4 0.44 7.05 0.36 1e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs4474465 0.833 rs10899540 chr11:78245549 T/A cg27205649 chr11:78285834 NARS2 0.5 6.09 0.32 3.12e-9 Alzheimer's disease (survival time); LUSC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg06145435 chr7:1022769 CYP2W1 0.33 5.71 0.3 2.56e-8 Bronchopulmonary dysplasia; LUSC trans rs72674100 1.000 rs72880598 chr4:97988599 A/G cg16405019 chr1:18959625 PAX7 -0.58 -6.33 -0.33 7.76e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7122539 0.506 rs7944999 chr11:66687863 A/G cg24851651 chr11:66362959 CCS 0.45 7.82 0.39 7.17e-14 HIV-1 susceptibility; LUSC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg13206674 chr6:150067644 NUP43 0.61 9.71 0.47 8.23e-20 Lung cancer; LUSC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg15147215 chr3:52552868 STAB1 -0.35 -6.97 -0.36 1.69e-11 Electroencephalogram traits; LUSC cis rs10465746 0.967 rs12757632 chr1:84416408 T/C cg10977910 chr1:84465055 TTLL7 0.43 6.33 0.33 7.96e-10 Obesity-related traits; LUSC trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg13615516 chr5:77269221 NA 0.4 6.76 0.35 6.09e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg04450456 chr4:17643702 FAM184B -0.35 -5.85 -0.3 1.17e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.83 0.3 1.29e-8 Rheumatoid arthritis; LUSC cis rs1467026 0.606 rs9814180 chr3:12818386 A/G cg05775895 chr3:12838266 CAND2 0.5 8.66 0.43 2.11e-16 P wave duration; LUSC cis rs9361491 0.508 rs9343789 chr6:79426581 A/G cg05283184 chr6:79620031 NA -0.39 -6.82 -0.35 4.26e-11 Intelligence (multi-trait analysis); LUSC cis rs7106204 0.514 rs12789549 chr11:24254726 C/G ch.11.24196551F chr11:24239977 NA 0.92 10.14 0.49 3.15e-21 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg21782813 chr7:2030301 MAD1L1 -0.49 -8.28 -0.41 2.99e-15 Bipolar disorder and schizophrenia; LUSC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg09323728 chr8:95962352 TP53INP1 -0.36 -7.22 -0.37 3.44e-12 Type 2 diabetes; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg00533393 chr11:747458 TALDO1 0.7 6.45 0.33 3.91e-10 Body mass index; LUSC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg24296786 chr1:45957014 TESK2 0.45 6.59 0.34 1.71e-10 High light scatter reticulocyte count; LUSC cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg01849466 chr14:104193079 ZFYVE21 -0.57 -9.26 -0.45 2.59e-18 Schizophrenia; LUSC cis rs12681287 0.752 rs1436628 chr8:87313345 C/G cg27223183 chr8:87520930 FAM82B 0.49 6.1 0.32 2.99e-9 Caudate activity during reward; LUSC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02018176 chr4:1364513 KIAA1530 0.72 12.87 0.58 4.52e-31 Longevity; LUSC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs427394 0.659 rs187295 chr5:6734326 C/T cg10857441 chr5:6722123 POLS -0.44 -8.06 -0.4 1.4e-14 Menopause (age at onset); LUSC cis rs17270561 0.562 rs74293932 chr6:26014811 C/A cg16482183 chr6:26056742 HIST1H1C 1.07 13.68 0.6 3.98e-34 Iron status biomarkers; LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg16103275 chr6:290800 DUSP22 -0.42 -7.21 -0.37 3.83e-12 Menopause (age at onset); LUSC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg18252515 chr7:66147081 NA -1.19 -13.56 -0.6 1.16e-33 Diabetic kidney disease; LUSC cis rs8017423 0.967 rs2282030 chr14:90730265 G/A cg14092571 chr14:90743983 NA -0.35 -5.71 -0.3 2.45e-8 Mortality in heart failure; LUSC cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg08847533 chr14:75593920 NEK9 0.84 14.69 0.63 4.81e-38 Height; LUSC cis rs7804356 1.000 rs10229837 chr7:26840652 G/A cg03456212 chr7:26904342 SKAP2 -0.55 -6.47 -0.33 3.54e-10 Type 1 diabetes; LUSC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.78 10.67 0.5 4.71e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2109514 0.650 rs12531767 chr7:116129005 T/A cg12739419 chr7:116140593 CAV2 -0.27 -5.77 -0.3 1.77e-8 Prevalent atrial fibrillation; LUSC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg12963246 chr6:28129442 ZNF389 0.54 7.47 0.38 7.25e-13 Depression; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13802269 chr4:120133706 USP53 0.77 6.15 0.32 2.16e-9 Cognitive performance; LUSC cis rs1784581 0.588 rs9346894 chr6:162430763 T/C cg17173639 chr6:162384350 PARK2 0.58 10.02 0.48 7.54e-21 Itch intensity from mosquito bite; LUSC cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg12011299 chr4:100065546 ADH4 0.72 11.13 0.52 1.13e-24 Alcohol dependence; LUSC cis rs34421088 0.532 rs2409754 chr8:11155613 A/G cg21775007 chr8:11205619 TDH 0.49 7.24 0.37 3.19e-12 Neuroticism; LUSC cis rs965513 1.000 rs7021576 chr9:100540541 C/T cg13688889 chr9:100608707 NA -0.56 -8.32 -0.41 2.35e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.13 -0.41 8.59e-15 Chronic sinus infection; LUSC cis rs2239547 0.563 rs4687699 chr3:53101224 C/T cg11645453 chr3:52864694 ITIH4 0.47 10.62 0.5 7.08e-23 Schizophrenia; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg24829409 chr8:58192753 C8orf71 0.58 6.33 0.33 7.89e-10 Developmental language disorder (linguistic errors); LUSC cis rs12579753 0.879 rs7958566 chr12:82131478 A/T cg21231944 chr12:82153410 PPFIA2 -0.4 -6.17 -0.32 1.98e-9 Resting heart rate; LUSC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg09021430 chr5:549028 NA -0.53 -6.97 -0.36 1.7e-11 Lung disease severity in cystic fibrosis; LUSC cis rs10789491 0.767 rs4660359 chr1:47190019 C/G cg15501359 chr1:47185051 KIAA0494 0.71 9.19 0.45 4.22e-18 Response to hepatitis C treatment; LUSC cis rs6782228 0.606 rs2712405 chr3:128332082 T/C cg16766828 chr3:128327626 NA -0.32 -5.84 -0.3 1.25e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs427394 0.632 rs169285 chr5:6736587 G/C cg10857441 chr5:6722123 POLS -0.44 -8.06 -0.4 1.36e-14 Menopause (age at onset); LUSC cis rs2439831 0.717 rs9806227 chr15:43680115 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.91 9.73 0.47 7.58e-20 Lung cancer in ever smokers; LUSC cis rs10464366 0.746 rs11760807 chr7:39142377 G/A cg18850127 chr7:39170497 POU6F2 0.62 9.37 0.46 1.12e-18 IgG glycosylation; LUSC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg13628971 chr7:2884303 GNA12 0.46 6.79 0.35 5.03e-11 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg26626185 chr16:74808370 FA2H 0.68 6.14 0.32 2.38e-9 Cognitive performance; LUSC cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.5 -0.46 4.07e-19 Schizophrenia; LUSC trans rs1325195 0.920 rs9726961 chr1:179089475 C/G cg11624085 chr17:8464688 MYH10 -0.44 -7.38 -0.37 1.25e-12 IgE grass sensitization; LUSC cis rs4845459 0.967 rs4845453 chr1:152591953 C/G cg08895932 chr1:152778580 LCE1C -0.35 -6.02 -0.31 4.57e-9 Psoriasis; LUSC cis rs12681287 0.547 rs9297922 chr8:87542317 A/G cg27223183 chr8:87520930 FAM82B 0.53 6.99 0.36 1.54e-11 Caudate activity during reward; LUSC cis rs2692947 0.567 rs4907276 chr2:96391109 G/T cg23100626 chr2:96804247 ASTL -0.25 -5.77 -0.3 1.84e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs72792276 0.818 rs57249773 chr5:127463166 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.92 7.84 0.39 5.98e-14 Red cell distribution width; LUSC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC trans rs1814175 0.653 rs10839480 chr11:50034556 C/T cg03929089 chr4:120376271 NA -1.03 -20.07 -0.74 2.47e-59 Height; LUSC trans rs2392780 0.536 rs437980 chr8:128335246 A/C cg10897648 chr18:56338258 MALT1 -0.41 -6.17 -0.32 1.92e-9 Breast cancer (early onset); LUSC cis rs7589342 0.895 rs2033008 chr2:106502585 T/A cg16077055 chr2:106428750 NCK2 0.34 6.29 0.33 1.02e-9 Addiction; LUSC cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg09307838 chr4:120376055 NA 0.77 11.09 0.52 1.55e-24 Corneal astigmatism; LUSC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg17971929 chr21:40555470 PSMG1 0.75 12.15 0.55 2.24e-28 Cognitive function; LUSC cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg09184832 chr6:79620586 NA -0.43 -6.96 -0.36 1.76e-11 Intelligence (multi-trait analysis); LUSC cis rs2239815 0.515 rs5762839 chr22:29231447 C/T cg02153584 chr22:29168773 CCDC117 0.57 6.71 0.34 8.38e-11 Esophageal cancer (squamous cell);Esophageal squamous cell carcinoma; LUSC cis rs7131987 0.617 rs3764953 chr12:29502236 T/C cg09582351 chr12:29534625 ERGIC2 -0.35 -7.15 -0.36 5.49e-12 QT interval; LUSC cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg22676075 chr6:135203613 NA -0.62 -10.0 -0.48 8.77e-21 High light scatter reticulocyte percentage of red cells; LUSC cis rs57590327 0.503 rs11706976 chr3:81899653 C/T cg07356753 chr3:81810745 GBE1 -0.65 -10.3 -0.49 8.94e-22 Extraversion; LUSC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -12.4 -0.56 2.66e-29 Lobe attachment (rater-scored or self-reported); LUSC cis rs7605827 0.930 rs6708288 chr2:15535477 A/G cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg08999081 chr20:33150536 PIGU 0.52 10.42 0.5 3.46e-22 Glomerular filtration rate (creatinine); LUSC cis rs7223966 1.000 rs17549954 chr17:61707032 A/G cg05941027 chr17:61774174 LIMD2 0.22 5.72 0.3 2.4e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.93 0.31 7.55e-9 Menopause (age at onset); LUSC cis rs9283706 0.764 rs17218390 chr5:66280426 A/G cg11590213 chr5:66331682 MAST4 0.41 5.96 0.31 6.27e-9 Coronary artery disease; LUSC cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg13010199 chr12:38710504 ALG10B 0.61 9.53 0.46 3.47e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs2354432 0.607 rs6677679 chr1:146803630 C/T cg25205988 chr1:146714368 CHD1L -1.03 -9.27 -0.45 2.31e-18 Mitochondrial DNA levels; LUSC cis rs9948 0.786 rs62156225 chr2:97414118 T/C cg01990225 chr2:97406019 LMAN2L -0.78 -5.86 -0.31 1.1e-8 Erectile dysfunction and prostate cancer treatment; LUSC cis rs950027 0.596 rs2467853 chr15:45698793 T/G cg04036182 chr15:45458818 NA 0.35 5.72 0.3 2.32e-8 Response to fenofibrate (adiponectin levels); LUSC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg11663144 chr21:46675770 NA -0.41 -7.14 -0.36 5.99e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs796364 0.806 rs10931887 chr2:200968905 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.98 -0.4 2.44e-14 Schizophrenia; LUSC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg10150615 chr22:24372951 LOC391322 -0.43 -7.13 -0.36 6.06e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg22535103 chr8:58192502 C8orf71 -0.82 -10.08 -0.48 4.74e-21 Developmental language disorder (linguistic errors); LUSC cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg24812749 chr6:127587940 RNF146 0.9 13.22 0.59 2.17e-32 Breast cancer; LUSC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg11764359 chr7:65958608 NA 0.68 11.06 0.52 2e-24 Aortic root size; LUSC cis rs13064411 0.696 rs6768979 chr3:113204149 G/A cg18753928 chr3:113234510 CCDC52 -0.52 -8.01 -0.4 1.99e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs4268898 1.000 rs4268898 chr2:24490413 C/T cg06627628 chr2:24431161 ITSN2 0.61 8.89 0.44 3.99e-17 Asthma; LUSC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.85 -0.3 1.16e-8 Major depressive disorder; LUSC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg13298116 chr11:62369859 EML3;MTA2 0.53 8.01 0.4 1.94e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4363385 0.747 rs1415970 chr1:152965741 G/C cg00922841 chr1:152955080 SPRR1A -0.44 -7.66 -0.39 2.08e-13 Inflammatory skin disease; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg21439498 chr19:59086698 MGC2752 -0.41 -5.97 -0.31 6.01e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg22920501 chr2:26401640 FAM59B -0.55 -7.33 -0.37 1.71e-12 Gut microbiome composition (summer); LUSC cis rs854765 0.547 rs4459604 chr17:17888549 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.78 13.99 0.61 2.45e-35 Total body bone mineral density; LUSC trans rs8073060 0.586 rs225264 chr17:33961335 A/G cg19694781 chr19:47549865 TMEM160 -1.13 -18.15 -0.7 1.04e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs7824557 0.527 rs2736298 chr8:11235136 C/G cg21775007 chr8:11205619 TDH -0.65 -10.32 -0.49 7.26e-22 Retinal vascular caliber; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg16132339 chr22:24313637 DDTL;DDT 0.41 6.43 0.33 4.37e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg12267291 chr8:126010467 SQLE 0.35 6.63 0.34 1.32e-10 Metabolite levels (Pyroglutamine); LUSC cis rs66569888 0.789 rs17213510 chr2:106742778 T/C cg16099169 chr2:106886729 NA -0.53 -6.54 -0.34 2.25e-10 Facial morphology (factor 23); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09130549 chr8:97247213 UQCRB 0.8 6.21 0.32 1.62e-9 Cognitive performance; LUSC cis rs12908161 0.959 rs11637728 chr15:85203392 A/T cg17507749 chr15:85114479 UBE2QP1 0.58 7.12 0.36 6.59e-12 Schizophrenia; LUSC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg06600287 chr1:53387719 ECHDC2 -0.28 -6.07 -0.32 3.52e-9 Monocyte count; LUSC cis rs2404602 0.536 rs11072599 chr15:76774508 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.03 -0.36 1.18e-11 Blood metabolite levels; LUSC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg26314531 chr2:26401878 FAM59B -0.69 -9.44 -0.46 6.75e-19 Gut microbiome composition (summer); LUSC cis rs7528419 0.617 rs4970834 chr1:109814880 C/T cg00908766 chr1:109817496 CELSR2 -0.61 -9.22 -0.45 3.53e-18 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; LUSC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg02136620 chr5:178986620 RUFY1 -0.46 -7.12 -0.36 6.68e-12 Lung cancer; LUSC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs1979679 0.573 rs4930825 chr12:28727107 A/G cg13890972 chr12:28721907 NA -0.41 -6.0 -0.31 5.13e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs6574644 1.000 rs6574641 chr14:81774111 T/C cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs2073300 0.609 rs17830281 chr20:23350525 C/T cg12062639 chr20:23401060 NAPB 0.98 8.12 0.41 9.29e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs59698941 0.882 rs66537260 chr5:132309237 C/T cg14825688 chr5:132208181 LEAP2 -0.54 -5.75 -0.3 2.01e-8 Apolipoprotein A-IV levels; LUSC cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.45 -0.42 9.36e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg06108461 chr20:60628389 TAF4 -1.01 -17.6 -0.69 1.63e-49 Body mass index; LUSC cis rs6456156 0.586 rs1358882 chr6:167467101 G/A cg07741184 chr6:167504864 NA 0.39 6.93 0.35 2.12e-11 Primary biliary cholangitis; LUSC cis rs7520050 0.778 rs3014218 chr1:46026328 A/C cg24296786 chr1:45957014 TESK2 0.44 6.06 0.31 3.75e-9 Red blood cell count;Reticulocyte count; LUSC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 14.13 0.61 7.23e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4253772 0.745 rs78023664 chr22:46647844 G/A cg09491104 chr22:46646882 C22orf40 -0.7 -6.82 -0.35 4.32e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.86 -0.31 1.08e-8 Total body bone mineral density; LUSC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.08 -0.32 3.37e-9 Platelet count; LUSC cis rs8017423 0.935 rs4904661 chr14:90729332 T/C cg04374321 chr14:90722782 PSMC1 0.76 12.04 0.55 5.82e-28 Mortality in heart failure; LUSC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg20243544 chr17:37824526 PNMT 0.39 5.76 0.3 1.96e-8 Self-reported allergy; LUSC trans rs9393777 0.920 rs34150729 chr6:27388754 T/C cg01620082 chr3:125678407 NA -0.81 -7.15 -0.36 5.36e-12 Intelligence (multi-trait analysis); LUSC trans rs8022206 0.659 rs986383 chr14:68327447 A/C cg15809352 chr2:121748218 GLI2 0.45 6.58 0.34 1.8e-10 Platelet count;Mean platelet volume; LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg22907277 chr7:1156413 C7orf50 0.68 7.36 0.37 1.46e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs244293 1.000 rs244288 chr17:53231841 G/A cg19360675 chr17:53046073 COX11;STXBP4 -0.4 -5.71 -0.3 2.52e-8 Menarche (age at onset); LUSC trans rs2700987 0.692 rs6953856 chr7:37386089 T/A cg26076750 chr5:98105150 RGMB -0.37 -6.63 -0.34 1.36e-10 Psoriasis vulgaris;Psoriasis; LUSC cis rs3960554 0.808 rs60481386 chr7:75700962 A/G cg17325771 chr7:75508891 RHBDD2 -0.4 -5.88 -0.31 9.71e-9 Eotaxin levels; LUSC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs2839186 0.565 rs2839183 chr21:47687144 G/A cg10657630 chr21:48055338 PRMT2 0.38 5.84 0.3 1.26e-8 Testicular germ cell tumor; LUSC cis rs1949733 0.523 rs16842563 chr4:8545146 C/T cg11789530 chr4:8429930 ACOX3 -0.41 -6.18 -0.32 1.82e-9 Response to antineoplastic agents; LUSC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg07424592 chr7:64974309 NA 0.71 6.19 0.32 1.72e-9 Diabetic kidney disease; LUSC cis rs7172677 0.768 rs72730585 chr15:75353906 A/G cg14664628 chr15:75095509 CSK 0.52 6.67 0.34 1.09e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs12579753 1.000 rs12580330 chr12:82241280 T/G cg07923666 chr12:49932857 KCNH3 -0.53 -6.53 -0.34 2.42e-10 Resting heart rate; LUSC cis rs2637266 0.935 rs4520537 chr10:78392978 C/T cg18941641 chr10:78392320 NA 0.41 7.45 0.38 8.27e-13 Pulmonary function; LUSC trans rs853679 0.517 rs7755442 chr6:28039015 T/C cg06606381 chr12:133084897 FBRSL1 -0.45 -6.09 -0.32 3.02e-9 Depression; LUSC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg06634786 chr22:41940651 POLR3H 0.52 6.16 0.32 2.11e-9 Vitiligo; LUSC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg22907277 chr7:1156413 C7orf50 0.49 7.56 0.38 3.84e-13 Longevity;Endometriosis; LUSC cis rs1577917 0.771 rs2758844 chr6:86330115 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.55 -8.79 -0.43 8.06e-17 Response to antipsychotic treatment; LUSC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg13206674 chr6:150067644 NUP43 0.56 8.73 0.43 1.2e-16 Lung cancer; LUSC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg02038168 chr22:39784481 NA -0.47 -7.86 -0.4 5.34e-14 Intelligence (multi-trait analysis); LUSC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg04455712 chr21:45112962 RRP1B 0.42 7.86 0.39 5.49e-14 Mean corpuscular volume; LUSC cis rs6964587 0.610 rs6950682 chr7:91464218 G/T cg17063962 chr7:91808500 NA 0.54 8.7 0.43 1.52e-16 Breast cancer; LUSC cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg25173405 chr17:45401733 C17orf57 0.37 5.75 0.3 2.01e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs3812049 0.784 rs2250127 chr5:127388844 G/A cg16011800 chr17:1958478 HIC1 0.46 6.17 0.32 1.94e-9 Lymphocyte counts;Red cell distribution width; LUSC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg23625390 chr15:77176239 SCAPER 0.5 7.73 0.39 1.31e-13 Blood metabolite levels; LUSC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg21733973 chr7:65235735 NA 0.43 6.13 0.32 2.5e-9 Calcium levels; LUSC cis rs9399401 1.000 rs1040525 chr6:142703669 C/T cg03128060 chr6:142623767 GPR126 0.32 5.94 0.31 7.24e-9 Chronic obstructive pulmonary disease; LUSC cis rs796364 1.000 rs71424239 chr2:200725473 T/C cg23649088 chr2:200775458 C2orf69 -0.54 -6.85 -0.35 3.55e-11 Schizophrenia; LUSC cis rs6842047 1.000 rs1511800 chr4:187135556 C/T cg09526685 chr4:187126073 CYP4V2 0.53 5.72 0.3 2.43e-8 Blood protein levels; LUSC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg19920283 chr7:105172520 RINT1 0.57 6.08 0.32 3.34e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.62e-8 Morning vs. evening chronotype; LUSC cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg00012203 chr2:219082015 ARPC2 -0.7 -11.58 -0.54 2.78e-26 Colorectal cancer; LUSC cis rs2279817 1.000 rs4920619 chr1:18023112 A/G cg21791023 chr1:18019539 ARHGEF10L 0.47 6.54 0.34 2.32e-10 Neuroticism; LUSC cis rs6582630 0.533 rs11504406 chr12:38334580 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.63 -0.39 2.45e-13 Drug-induced liver injury (flucloxacillin); LUSC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg07701084 chr6:150067640 NUP43 0.49 7.26 0.37 2.69e-12 Lung cancer; LUSC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg20608306 chr11:116969690 SIK3 0.38 6.33 0.33 8.09e-10 Blood protein levels; LUSC cis rs7312933 0.618 rs7315968 chr12:42637086 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.48 6.74 0.35 7.17e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9325144 0.647 rs7487395 chr12:38865660 C/A cg13010199 chr12:38710504 ALG10B -0.49 -7.45 -0.38 8.18e-13 Morning vs. evening chronotype; LUSC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg10909506 chr17:38081995 ORMDL3 0.34 6.07 0.32 3.55e-9 Self-reported allergy; LUSC trans rs1864585 0.520 rs17776427 chr8:10672972 G/T cg26278703 chr11:58910052 FAM111A 0.58 6.3 0.33 9.3e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg23711669 chr6:146136114 FBXO30 0.78 12.61 0.57 4.33e-30 Lobe attachment (rater-scored or self-reported); LUSC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg07414643 chr4:187882934 NA -0.38 -6.17 -0.32 2.03e-9 Lobe attachment (rater-scored or self-reported); LUSC trans rs1814175 0.935 rs11040438 chr11:49622521 G/A cg03929089 chr4:120376271 NA -0.98 -17.61 -0.69 1.49e-49 Height; LUSC cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg24642439 chr20:33292090 TP53INP2 0.49 7.42 0.38 9.78e-13 Glomerular filtration rate (creatinine); LUSC trans rs61931739 0.500 rs6488224 chr12:34537205 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs5750830 0.620 rs1007337 chr22:39781585 C/T cg02038168 chr22:39784481 NA -0.49 -8.02 -0.4 1.78e-14 Intelligence (multi-trait analysis); LUSC cis rs12701220 0.542 rs6957866 chr7:1111674 G/A cg26769984 chr7:1090371 C7orf50 0.57 7.16 0.36 5.3e-12 Bronchopulmonary dysplasia; LUSC cis rs2797160 1.000 rs1777183 chr6:126011995 A/C cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.94e-16 Endometrial cancer; LUSC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 6.07 0.32 3.42e-9 Hip circumference adjusted for BMI; LUSC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg02376097 chr19:46275166 DMPK 0.4 6.99 0.36 1.49e-11 Coronary artery disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg10339344 chr11:60674203 PRPF19 0.46 6.35 0.33 6.88e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6961069 0.538 rs3173800 chr7:80289921 A/T cg04458919 chr7:80252533 CD36 -0.38 -6.52 -0.34 2.58e-10 Platelet count; LUSC trans rs11098499 0.863 rs6833334 chr4:120504227 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.76 0.35 6.2e-11 Corneal astigmatism; LUSC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg06634786 chr22:41940651 POLR3H 0.48 5.68 0.3 2.95e-8 Cannabis dependence symptom count; LUSC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7607369 0.559 rs13002060 chr2:219660394 G/T cg02176678 chr2:219576539 TTLL4 -0.54 -9.62 -0.47 1.72e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs1577917 0.916 rs12198730 chr6:86555138 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.72 -0.35 7.84e-11 Response to antipsychotic treatment; LUSC cis rs7223966 1.000 rs8078862 chr17:61854068 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.98 0.36 1.58e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg16339924 chr4:17578868 LAP3 0.57 8.81 0.43 6.77e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs3774749 0.565 rs2624839 chr3:50202231 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.42 6.17 0.32 2.03e-9 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg13319975 chr6:146136371 FBXO30 0.48 7.25 0.37 3.01e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs595982 0.559 rs4802516 chr19:49366170 T/C cg15549821 chr19:49342101 PLEKHA4 -0.59 -8.06 -0.4 1.37e-14 Red cell distribution width; LUSC cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg06092702 chr1:163392909 NA -0.44 -7.53 -0.38 4.83e-13 Motion sickness; LUSC cis rs9325144 0.647 rs870431 chr12:38953073 T/C cg26384229 chr12:38710491 ALG10B -0.61 -9.3 -0.45 1.86e-18 Morning vs. evening chronotype; LUSC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs9300255 0.739 rs1533703 chr12:123742093 T/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.38 -6.24 -0.32 1.35e-9 Neutrophil percentage of white cells; LUSC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg18350739 chr11:68623251 NA -0.36 -6.35 -0.33 7.2e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9649213 0.533 rs1541409 chr7:98027580 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.77 -11.0 -0.52 3.19e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs34779708 0.931 rs4934719 chr10:35376769 T/C cg03585969 chr10:35415529 CREM 0.62 9.08 0.44 9.71e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7180079 0.544 rs4777594 chr15:65076993 A/G cg08069370 chr15:64387884 SNX1 0.55 5.87 0.31 1.05e-8 Monocyte count; LUSC cis rs4363385 0.510 rs11205182 chr1:153045748 C/T cg25856811 chr1:152973957 SPRR3 -0.37 -6.16 -0.32 2.04e-9 Inflammatory skin disease; LUSC cis rs4604732 0.536 rs4925674 chr1:247636906 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.45 6.94 0.35 2.11e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs9325144 0.560 rs6582561 chr12:38666821 G/A cg13010199 chr12:38710504 ALG10B -0.51 -7.67 -0.39 1.87e-13 Morning vs. evening chronotype; LUSC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg27494647 chr7:150038898 RARRES2 0.46 7.21 0.37 3.71e-12 Blood protein levels;Circulating chemerin levels; LUSC trans rs28735056 0.591 rs62101204 chr18:77712832 G/A cg05926928 chr17:57297772 GDPD1 0.48 6.94 0.36 2.01e-11 Schizophrenia; LUSC trans rs10851478 0.872 rs11852336 chr15:49948824 T/C cg23074453 chr15:44487924 FRMD5 -0.33 -6.12 -0.32 2.61e-9 Oral cavity cancer; LUSC cis rs2303282 0.716 rs2241957 chr16:56401294 T/C cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg08048268 chr3:133502702 NA -0.38 -6.92 -0.35 2.25e-11 Iron status biomarkers; LUSC cis rs28374715 0.635 rs8023530 chr15:41647775 T/C cg18705301 chr15:41695430 NDUFAF1 -0.94 -19.67 -0.73 9.36e-58 Ulcerative colitis; LUSC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg25767906 chr1:53392781 SCP2 -0.54 -10.54 -0.5 1.27e-22 Monocyte count; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27597084 chr11:124670238 C11orf61 0.39 5.98 0.31 5.73e-9 Asthma; LUSC cis rs7312933 0.558 rs11181483 chr12:42798384 G/C cg01256987 chr12:42539512 GXYLT1 -0.41 -7.47 -0.38 7.03e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg24920358 chr1:40204285 PPIE -0.59 -10.59 -0.5 8.72e-23 Blood protein levels; LUSC cis rs62064224 0.509 rs2302276 chr17:30791503 C/T cg18200150 chr17:30822561 MYO1D 0.3 5.79 0.3 1.59e-8 Schizophrenia; LUSC cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -6.68 -0.34 9.79e-11 Monocyte percentage of white cells; LUSC cis rs11031096 0.811 rs4910599 chr11:4156040 T/A cg18678763 chr11:4115507 RRM1 -0.5 -7.34 -0.37 1.59e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2617583 0.967 rs2617595 chr5:1448246 C/T cg07148919 chr5:1466943 LPCAT1 0.42 6.32 0.33 8.17e-10 Breast cancer; LUSC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.13e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2729354 0.502 rs2848641 chr11:57263068 G/C cg24343310 chr11:57249947 NA 0.42 8.85 0.44 5.35e-17 Blood protein levels; LUSC cis rs867529 0.600 rs335120 chr2:89072731 A/G cg26627705 chr2:89060884 NA 0.4 5.7 0.3 2.62e-8 Height; LUSC cis rs9910055 0.639 rs11656871 chr17:42269141 G/C cg16434002 chr17:42200994 HDAC5 -0.43 -5.99 -0.31 5.34e-9 Total body bone mineral density; LUSC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.08 16.47 0.67 4.75e-45 Age-related macular degeneration (geographic atrophy); LUSC cis rs714027 0.585 rs41168 chr22:30418161 A/C cg11564601 chr22:30592435 NA -0.36 -6.22 -0.32 1.52e-9 Lymphocyte counts; LUSC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg25067162 chr17:41277974 BRCA1;NBR2 0.36 5.94 0.31 7.17e-9 Menopause (age at onset); LUSC cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg20701182 chr2:24300061 SF3B14 0.87 11.33 0.53 2.12e-25 Lymphocyte counts; LUSC cis rs10911363 0.550 rs10911353 chr1:183489203 G/A cg09173681 chr1:183549694 NCF2 0.64 11.45 0.53 7.79e-26 Systemic lupus erythematosus; LUSC cis rs1943345 0.642 rs11233500 chr11:82881407 C/T cg07047830 chr11:82868014 PCF11 -0.7 -10.97 -0.51 3.97e-24 Obesity-related traits; LUSC cis rs754466 1.000 rs12220328 chr10:79681482 G/C cg17075019 chr10:79541650 NA -0.63 -8.5 -0.42 6.18e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs11571404 1 rs11571404 chr12:1041450 C/T cg27417659 chr7:98567827 TRRAP -0.51 -6.5 -0.34 3e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs1153858 1.000 rs1145081 chr15:45679667 C/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.33 0.49 6.78e-22 Homoarginine levels; LUSC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg07332563 chr6:291687 DUSP22 -0.51 -7.86 -0.4 5.2e-14 Menopause (age at onset); LUSC cis rs3020736 0.500 rs5996111 chr22:42493902 C/T cg04733989 chr22:42467013 NAGA -0.63 -9.79 -0.47 4.63e-20 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs3768617 0.510 rs10911239 chr1:183062450 T/C ch.1.3577855R chr1:183094577 LAMC1 0.7 10.75 0.51 2.35e-23 Fuchs's corneal dystrophy; LUSC cis rs807669 0.548 rs762522 chr22:19180575 C/T cg02655711 chr22:19163373 SLC25A1 0.68 12.44 0.56 1.81e-29 Metabolite levels; LUSC cis rs8016982 0.662 rs8014406 chr14:81657760 A/C cg01989461 chr14:81687754 GTF2A1 0.5 6.63 0.34 1.35e-10 Schizophrenia; LUSC trans rs984440 0.542 rs7815305 chr8:139083637 T/C cg03334052 chr1:168888044 NA 0.4 6.44 0.33 4.26e-10 Obesity-related traits; LUSC cis rs4478858 0.595 rs4949387 chr1:31803440 T/A cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs10979 1.000 rs13211390 chr6:143888010 A/T cg25407410 chr6:143891975 LOC285740 -0.74 -11.93 -0.55 1.4e-27 Hypospadias; LUSC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 3.1e-34 Prudent dietary pattern; LUSC cis rs10186029 0.509 rs1122846 chr2:213939354 C/G cg08319019 chr2:214017104 IKZF2 0.45 6.63 0.34 1.36e-10 Systemic sclerosis; LUSC cis rs2204008 0.563 rs2320512 chr12:38266913 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.97 -0.36 1.72e-11 Bladder cancer; LUSC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.01 -0.31 4.73e-9 Total body bone mineral density; LUSC cis rs778371 0.723 rs35491427 chr2:233688542 C/T cg08000102 chr2:233561755 GIGYF2 -0.77 -12.28 -0.56 7.13e-29 Schizophrenia; LUSC cis rs654950 0.840 rs116241899 chr1:41994546 T/C cg06885757 chr1:42089581 HIVEP3 -0.34 -6.61 -0.34 1.52e-10 Airway imaging phenotypes; LUSC cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg08564027 chr20:61660810 NA 0.91 17.54 0.69 2.68e-49 Prostate cancer (SNP x SNP interaction); LUSC cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.63 0.86 5.12e-99 Chronic sinus infection; LUSC cis rs4803468 1.000 rs10409485 chr19:41920765 C/T cg05360949 chr19:41903737 BCKDHA;EXOSC5 -0.44 -6.33 -0.33 7.79e-10 Height; LUSC cis rs1355223 0.966 rs11602318 chr11:34766983 C/T cg11058730 chr11:34937778 PDHX;APIP 0.43 6.05 0.31 3.85e-9 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg22920501 chr2:26401640 FAM59B -0.78 -10.78 -0.51 1.94e-23 Gut microbiome composition (summer); LUSC cis rs4343996 0.566 rs6967278 chr7:3396185 A/G cg21248987 chr7:3385318 SDK1 -0.35 -5.79 -0.3 1.67e-8 Motion sickness; LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg00814883 chr7:100076585 TSC22D4 -0.75 -10.38 -0.49 4.47e-22 Platelet count; LUSC cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg01579765 chr21:45077557 HSF2BP 0.5 10.54 0.5 1.31e-22 Mean corpuscular volume; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg23760189 chr11:58910128 FAM111A 0.7 6.01 0.31 4.96e-9 Body mass index; LUSC cis rs778371 0.755 rs778352 chr2:233804330 A/T cg08000102 chr2:233561755 GIGYF2 -0.5 -6.78 -0.35 5.42e-11 Schizophrenia; LUSC cis rs9646954 0.542 rs4149513 chr2:101022726 C/T cg08017756 chr2:100939284 LONRF2 -0.48 -9.11 -0.45 8.01e-18 Intelligence (multi-trait analysis); LUSC cis rs2041895 0.509 rs1838445 chr12:107314585 T/A cg13944111 chr12:107296891 NA 0.37 6.5 0.34 2.95e-10 Glaucoma (low intraocular pressure); LUSC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg18876405 chr7:65276391 NA -0.56 -8.93 -0.44 3e-17 Aortic root size; LUSC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg17366294 chr4:99064904 C4orf37 0.54 8.93 0.44 2.96e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs9399135 0.967 rs2297340 chr6:135376058 T/C cg22676075 chr6:135203613 NA 0.46 7.21 0.37 3.84e-12 Red blood cell count; LUSC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs1801251 1.000 rs2305137 chr2:233712049 G/A cg08000102 chr2:233561755 GIGYF2 -0.7 -11.66 -0.54 1.34e-26 Coronary artery disease; LUSC cis rs6580649 0.941 rs72644842 chr12:48448274 A/G cg24011408 chr12:48396354 COL2A1 -0.46 -6.13 -0.32 2.43e-9 Lung cancer; LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18099408 chr3:52552593 STAB1 -0.41 -7.2 -0.37 3.98e-12 Electroencephalogram traits; LUSC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg19812747 chr11:111475976 SIK2 -0.53 -7.89 -0.4 4.28e-14 Primary sclerosing cholangitis; LUSC cis rs7191439 0.858 rs2340973 chr16:88773396 G/A cg02389323 chr16:88786976 FAM38A 1.16 10.45 0.5 2.67e-22 Plateletcrit; LUSC cis rs763121 0.886 rs1013339 chr22:38974680 C/T cg06022373 chr22:39101656 GTPBP1 0.8 13.2 0.59 2.68e-32 Menopause (age at onset); LUSC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg18681998 chr4:17616180 MED28 0.8 14.42 0.62 5.52e-37 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg02609749 chr16:89786786 C16orf7;ZNF276 0.47 7.85 0.39 5.84e-14 Vitiligo; LUSC cis rs790123 0.692 rs790126 chr3:122387655 G/A cg00926285 chr3:122398533 PARP14 -0.39 -5.66 -0.3 3.3e-8 Response to angiotensin II receptor blocker therapy; LUSC cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg23711669 chr6:146136114 FBXO30 0.81 13.98 0.61 2.84e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs3892630 0.588 rs7248798 chr19:33303684 G/T cg27413643 chr19:33165484 ANKRD27;RGS9BP -0.5 -5.65 -0.3 3.48e-8 Red blood cell traits; LUSC cis rs72781680 1.000 rs72781658 chr2:24220141 A/G cg08917208 chr2:24149416 ATAD2B 1.0 10.49 0.5 1.91e-22 Lymphocyte counts; LUSC cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg18131467 chr2:239335373 ASB1 -1.05 -25.06 -0.81 1.02e-78 Multiple system atrophy; LUSC trans rs62238980 0.614 rs117629537 chr22:32400579 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs2652834 0.851 rs1007075 chr15:63413501 A/G cg05507819 chr15:63340323 TPM1 0.44 5.72 0.3 2.35e-8 HDL cholesterol; LUSC cis rs34779708 0.931 rs34876468 chr10:35424450 G/A cg03585969 chr10:35415529 CREM 0.6 8.76 0.43 9.64e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs853679 1.000 rs6905391 chr6:28262686 G/A cg06606381 chr12:133084897 FBRSL1 -0.56 -6.62 -0.34 1.39e-10 Depression; LUSC cis rs4970988 0.526 rs6655975 chr1:150542128 A/G cg17724175 chr1:150552817 MCL1 -0.45 -7.87 -0.4 4.82e-14 Urate levels; LUSC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs3026401 0.562 rs2863231 chr11:31796560 C/T cg06552810 chr11:31128660 NA -0.35 -5.89 -0.31 9.37e-9 Body mass index; LUSC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg03676636 chr4:99064102 C4orf37 0.33 7.16 0.36 5.04e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs11958404 0.932 rs11950297 chr5:157419938 T/G cg05962755 chr5:157440814 NA 0.55 6.61 0.34 1.53e-10 IgG glycosylation; LUSC cis rs295140 1.000 rs7584810 chr2:201167772 G/A cg04283868 chr2:201171347 SPATS2L 0.44 6.61 0.34 1.56e-10 QT interval; LUSC cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg05347473 chr6:146136440 FBXO30 -0.48 -8.0 -0.4 2.13e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg17507749 chr15:85114479 UBE2QP1 0.69 9.0 0.44 1.76e-17 Schizophrenia; LUSC cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg27129171 chr3:47204927 SETD2 -0.69 -11.57 -0.53 2.89e-26 Colorectal cancer; LUSC cis rs7575217 0.961 rs7572504 chr2:101779739 C/T cg23907051 chr2:101730305 TBC1D8 -0.26 -6.69 -0.34 9.44e-11 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg06212747 chr3:49208901 KLHDC8B 0.44 5.93 0.31 7.68e-9 Parkinson's disease; LUSC cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg12826209 chr6:26865740 GUSBL1 0.76 6.5 0.33 2.98e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs8032315 0.895 rs4932370 chr15:91404705 A/G cg05469396 chr15:91419421 FURIN 0.37 6.01 0.31 4.92e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs4343996 0.754 rs6461983 chr7:3347339 A/G cg21248987 chr7:3385318 SDK1 0.37 6.35 0.33 6.83e-10 Motion sickness; LUSC cis rs7605827 0.930 rs2111455 chr2:15549882 C/T cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.08e-17 Educational attainment (years of education); LUSC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg03806693 chr22:41940476 POLR3H -1.05 -15.37 -0.64 1.09e-40 Vitiligo; LUSC cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.56 0.5 1.11e-22 Homoarginine levels; LUSC cis rs9462027 0.628 rs9462015 chr6:34739726 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.91 -0.31 8.62e-9 Systemic lupus erythematosus; LUSC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg06627628 chr2:24431161 ITSN2 -0.61 -7.32 -0.37 1.88e-12 Lymphocyte counts; LUSC cis rs41271473 0.948 rs11803118 chr1:228826831 A/G cg10167378 chr1:228756711 NA 0.6 7.07 0.36 9.23e-12 Chronic lymphocytic leukemia; LUSC cis rs6582630 0.622 rs11831595 chr12:38511489 C/A cg13010199 chr12:38710504 ALG10B -0.43 -6.54 -0.34 2.36e-10 Drug-induced liver injury (flucloxacillin); LUSC trans rs4689592 0.503 rs2292461 chr4:7058473 C/T cg11635098 chr7:100497156 NA -0.38 -6.09 -0.32 3.08e-9 Monocyte percentage of white cells; LUSC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg18681998 chr4:17616180 MED28 0.87 16.11 0.66 1.27e-43 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg04460285 chr2:113522412 CKAP2L 0.39 5.95 0.31 6.75e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs8062405 0.755 rs55792032 chr16:28599411 A/G cg07382826 chr16:28625726 SULT1A1 0.27 5.82 0.3 1.4e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs34779708 0.966 rs11010129 chr10:35510822 T/C cg03585969 chr10:35415529 CREM 0.64 9.53 0.46 3.46e-19 Inflammatory bowel disease;Crohn's disease; LUSC trans rs73228161 1.000 rs73228167 chr12:94663925 C/G cg27125177 chr10:85956635 PCDH21 -0.5 -6.15 -0.32 2.27e-9 Major depressive disorder; LUSC cis rs4285028 0.699 rs12637968 chr3:121599976 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.44 -0.46 6.61e-19 Multiple sclerosis; LUSC cis rs3743266 0.613 rs1063100 chr15:60734697 A/G cg21667061 chr15:60772094 NARG2 -0.37 -6.2 -0.32 1.65e-9 Menarche (age at onset); LUSC cis rs250677 0.522 rs10038913 chr5:148354224 A/G cg18129178 chr5:148520854 ABLIM3 0.53 7.83 0.39 6.34e-14 Breast cancer; LUSC cis rs10504073 0.584 rs115370638 chr8:49916452 A/G cg00325661 chr8:49890786 NA 0.7 11.24 0.52 4.39e-25 Blood metabolite ratios; LUSC cis rs4240897 0.935 rs3766744 chr1:12043717 G/A cg13216073 chr1:12042593 MFN2 0.36 6.35 0.33 7.14e-10 Tuberculosis; LUSC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg19592336 chr6:28129416 ZNF389 0.48 6.35 0.33 7.02e-10 Parkinson's disease; LUSC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg09509183 chr1:209979624 IRF6 0.49 5.84 0.3 1.25e-8 Cleft lip with or without cleft palate; LUSC trans rs2204008 0.775 rs11514370 chr12:38305566 G/A cg06521331 chr12:34319734 NA -0.41 -6.35 -0.33 7.23e-10 Bladder cancer; LUSC cis rs4595586 0.525 rs7136425 chr12:39376005 C/A cg26384229 chr12:38710491 ALG10B 0.48 6.94 0.35 2.06e-11 Morning vs. evening chronotype; LUSC cis rs7568458 0.846 rs6738645 chr2:85783128 T/G cg23752985 chr2:85803571 VAMP8 0.33 6.98 0.36 1.57e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs13108904 0.846 rs4045131 chr4:1228797 A/G cg23835219 chr4:1244017 CTBP1;C4orf42 0.32 6.07 0.32 3.46e-9 Obesity-related traits; LUSC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg09365446 chr1:150670422 GOLPH3L -0.54 -8.33 -0.41 2.1e-15 Tonsillectomy; LUSC cis rs4363385 0.755 rs1933382 chr1:153003295 G/T cg25856811 chr1:152973957 SPRR3 0.36 5.94 0.31 7.06e-9 Inflammatory skin disease; LUSC cis rs9300255 0.679 rs10772998 chr12:123721177 T/G cg00376283 chr12:123451042 ABCB9 0.65 8.31 0.41 2.45e-15 Neutrophil percentage of white cells; LUSC cis rs62400317 0.859 rs72858511 chr6:45218119 A/G cg20913747 chr6:44695427 NA -0.49 -7.8 -0.39 7.8500000000000006e-14 Total body bone mineral density; LUSC cis rs892961 0.899 rs7222532 chr17:75413302 G/C cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg24531977 chr5:56204891 C5orf35 -0.57 -8.31 -0.41 2.5e-15 Coronary artery disease; LUSC cis rs3849570 0.732 rs11715625 chr3:81875938 A/T cg07356753 chr3:81810745 GBE1 -0.59 -8.81 -0.43 6.92e-17 Waist circumference;Body mass index; LUSC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10089 1.000 rs1962291 chr5:127445373 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.87 -12.39 -0.56 2.84e-29 Ileal carcinoids; LUSC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg20135002 chr11:47629003 NA -0.49 -7.81 -0.39 7.55e-14 Subjective well-being; LUSC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg19622623 chr12:86230825 RASSF9 0.4 5.71 0.3 2.44e-8 Major depressive disorder; LUSC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.48 -0.33 3.34e-10 Lung cancer; LUSC trans rs35110281 0.774 rs1003280 chr21:44997322 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.77 0.47 5.46e-20 Mean corpuscular volume; LUSC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg21724239 chr8:58056113 NA 0.61 7.21 0.37 3.7e-12 Developmental language disorder (linguistic errors); LUSC cis rs3125734 0.608 rs7905731 chr10:64018472 T/C cg19640130 chr10:64028056 RTKN2 -0.4 -7.1 -0.36 7.59e-12 Rheumatoid arthritis; LUSC cis rs6964587 0.967 rs17164315 chr7:91659150 C/G cg01689657 chr7:91764605 CYP51A1 0.32 5.79 0.3 1.6e-8 Breast cancer; LUSC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg00814883 chr7:100076585 TSC22D4 -0.74 -9.93 -0.48 1.55e-20 Platelet count; LUSC cis rs3087591 0.960 rs2905883 chr17:29550141 G/A cg24425628 chr17:29625626 OMG;NF1 0.54 7.89 0.4 4.46e-14 Hip circumference; LUSC cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg03676636 chr4:99064102 C4orf37 0.38 7.88 0.4 4.55e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs240764 0.717 rs6904959 chr6:101157916 C/T cg09795085 chr6:101329169 ASCC3 -0.42 -6.07 -0.32 3.52e-9 Neuroticism; LUSC cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg04450456 chr4:17643702 FAM184B 0.37 6.12 0.32 2.66e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6582618 1 rs6582618 chr12:38726137 A/G cg26384229 chr12:38710491 ALG10B 0.6 9.19 0.45 4.24e-18 Morning vs. evening chronotype; LUSC cis rs9463078 0.753 rs1329716 chr6:44953758 C/T cg25276700 chr6:44698697 NA -0.28 -5.76 -0.3 1.94e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs911555 0.755 rs8018400 chr14:103901085 A/G cg24130564 chr14:104152367 KLC1 0.45 6.49 0.33 3.14e-10 Intelligence (multi-trait analysis); LUSC cis rs2236918 1.000 rs2526701 chr1:242018427 T/C cg17736920 chr1:242011382 EXO1 0.45 7.12 0.36 6.71e-12 Menopause (age at onset); LUSC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg11764359 chr7:65958608 NA 0.54 6.97 0.36 1.75e-11 Aortic root size; LUSC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg12311346 chr5:56204834 C5orf35 -1.08 -16.19 -0.66 6.07e-44 Initial pursuit acceleration; LUSC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg14004847 chr7:1930337 MAD1L1 -0.52 -7.88 -0.4 4.69e-14 Bipolar disorder and schizophrenia; LUSC cis rs10876993 0.928 rs1689596 chr12:58053029 T/C cg18357645 chr12:58087776 OS9 0.56 8.51 0.42 5.79e-16 Celiac disease or Rheumatoid arthritis; LUSC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg17968037 chr7:100024898 ZCWPW1 -0.39 -6.07 -0.31 3.57e-9 Platelet count; LUSC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg21724239 chr8:58056113 NA 0.62 7.06 0.36 9.73e-12 Developmental language disorder (linguistic errors); LUSC cis rs10208940 0.920 rs13422657 chr2:68706989 T/C cg12452813 chr2:68675892 NA 0.56 5.88 0.31 1.01e-8 Urate levels in lean individuals; LUSC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg09034736 chr1:150693464 HORMAD1 0.52 7.51 0.38 5.52e-13 Tonsillectomy; LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg27588902 chr6:42928151 GNMT -0.29 -6.57 -0.34 1.93e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs5758511 0.680 rs1001586 chr22:42670293 G/T cg00645731 chr22:42541494 CYP2D7P1 0.58 10.25 0.49 1.31e-21 Birth weight; LUSC cis rs3845702 1.000 rs259808 chr2:180791419 T/G cg01881094 chr2:180872142 CWC22 -0.8 -9.94 -0.48 1.5e-20 Schizophrenia; LUSC cis rs61990749 0.544 rs7151211 chr14:78151901 C/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.61 -6.49 -0.33 3.14e-10 Fibroblast growth factor basic levels; LUSC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg13393036 chr8:95962371 TP53INP1 -0.45 -9.58 -0.46 2.21e-19 Type 2 diabetes; LUSC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg03452623 chr4:187889614 NA -0.88 -18.62 -0.71 1.43e-53 Lobe attachment (rater-scored or self-reported); LUSC cis rs2629540 0.781 rs2293064 chr10:126396511 C/G cg08799069 chr10:126477246 METTL10 0.5 7.43 0.38 8.88e-13 Cocaine dependence; LUSC cis rs6084875 0.840 rs6084850 chr20:4725662 G/A cg26097573 chr20:4721490 PRNT -0.31 -5.74 -0.3 2.16e-8 Systemic lupus erythematosus; LUSC cis rs4906332 0.966 rs12588705 chr14:103865477 T/A cg04998671 chr14:104000505 TRMT61A -0.46 -7.13 -0.36 6.27e-12 Coronary artery disease; LUSC cis rs240993 0.595 rs1040383 chr6:111902188 C/G cg22127309 chr6:111907043 TRAF3IP2 0.34 6.06 0.31 3.58e-9 Inflammatory skin disease;Psoriasis; LUSC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg09365446 chr1:150670422 GOLPH3L 0.55 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs12530845 0.943 rs78188670 chr7:135335163 T/C cg23117316 chr7:135346802 PL-5283 -0.57 -9.84 -0.47 3.1e-20 Red blood cell traits; LUSC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg22105103 chr4:187893119 NA 0.72 14.01 0.61 2.12e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs6756513 0.520 rs7569566 chr2:70174030 T/C cg02498382 chr2:70120550 SNRNP27 -0.26 -6.52 -0.34 2.54e-10 Breast cancer;Platelet count; LUSC cis rs1971762 0.583 rs12319789 chr12:54090450 G/C cg23533419 chr12:54090519 NA -0.36 -5.76 -0.3 1.88e-8 Height; LUSC trans rs7824557 0.564 rs7828263 chr8:11231886 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.69 -0.43 1.66e-16 Retinal vascular caliber; LUSC trans rs61931739 0.534 rs11053049 chr12:34164537 T/C cg26384229 chr12:38710491 ALG10B 0.74 11.93 0.55 1.42e-27 Morning vs. evening chronotype; LUSC cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg12564285 chr5:131593104 PDLIM4 0.37 6.8 0.35 4.9e-11 Blood metabolite levels; LUSC cis rs16976116 0.951 rs3759862 chr15:55483104 C/A cg11288833 chr15:55489084 RSL24D1 0.53 6.35 0.33 7.21e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg06494592 chr3:125709126 NA -0.5 -5.7 -0.3 2.62e-8 Blood pressure (smoking interaction); LUSC cis rs2348418 0.715 rs10843206 chr12:28722756 C/T cg13890972 chr12:28721907 NA -0.39 -6.89 -0.35 2.81e-11 Lung function (FVC);Lung function (FEV1); LUSC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg08683831 chr4:1404607 NA 0.36 6.02 0.31 4.52e-9 Obesity-related traits; LUSC cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -7.82 -0.39 7.05e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg22437258 chr11:111473054 SIK2 0.54 7.6 0.38 3.03e-13 Primary sclerosing cholangitis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24103018 chr19:17420930 DDA1 -0.48 -6.16 -0.32 2.1e-9 Bipolar disorder and schizophrenia; LUSC cis rs600231 0.708 rs3132767 chr11:65234860 C/T cg21890820 chr11:65308645 LTBP3 0.5 7.41 0.38 1.03e-12 Bone mineral density; LUSC cis rs4073582 0.555 rs521109 chr11:66030948 G/A cg16950941 chr11:66035639 RAB1B 0.54 8.01 0.4 1.97e-14 Gout; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25173401 chr4:53548 ZNF595;ZNF718 0.43 6.64 0.34 1.3e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg06074448 chr4:187884817 NA -0.41 -6.87 -0.35 3.24e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg13047869 chr3:10149882 C3orf24 0.6 8.12 0.41 9.19e-15 Alzheimer's disease; LUSC cis rs637571 0.510 rs10750772 chr11:65577427 C/T cg10604040 chr11:65559109 OVOL1 0.31 5.78 0.3 1.72e-8 Eosinophil percentage of white cells; LUSC cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg08213375 chr14:104286397 PPP1R13B -0.53 -10.13 -0.48 3.33e-21 Schizophrenia; LUSC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg07636037 chr3:49044803 WDR6 1.03 18.02 0.7 3.34e-51 Parkinson's disease; LUSC cis rs829883 0.659 rs11109521 chr12:98930809 C/A cg25150519 chr12:98850993 NA -0.63 -8.71 -0.43 1.47e-16 Colorectal adenoma (advanced); LUSC cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg26384229 chr12:38710491 ALG10B 0.86 14.72 0.63 3.93e-38 Bladder cancer; LUSC cis rs7677751 0.806 rs890203 chr4:55097405 A/C cg17187183 chr4:55093834 PDGFRA 0.39 5.89 0.31 9.61e-9 Corneal astigmatism; LUSC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg18904891 chr8:8559673 CLDN23 0.56 7.65 0.39 2.14e-13 Obesity-related traits; LUSC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg03517284 chr6:25882590 NA -0.42 -6.57 -0.34 1.92e-10 Intelligence (multi-trait analysis); LUSC cis rs6752107 0.935 rs10929322 chr2:234149702 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.65 -10.91 -0.51 6.55e-24 Crohn's disease;Inflammatory bowel disease; LUSC cis rs7916410 0.512 rs1900003 chr10:70004551 A/C cg06988349 chr10:69991859 ATOH7 0.33 5.8 0.3 1.56e-8 Optic disc area; LUSC cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg23711669 chr6:146136114 FBXO30 0.85 15.25 0.64 3.1e-40 Lobe attachment (rater-scored or self-reported); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg25508527 chr19:7294983 INSR 0.7 6.13 0.32 2.55e-9 Cognitive performance; LUSC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.92 0.31 7.86e-9 Menopause (age at onset); LUSC cis rs469568 0.935 rs338875 chr5:178669297 A/G cg08999896 chr5:178685787 ADAMTS2 -0.29 -6.1 -0.32 3.01e-9 Stroke (pediatric); LUSC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg10295955 chr4:187884368 NA -1.04 -22.89 -0.78 2.15e-70 Lobe attachment (rater-scored or self-reported); LUSC trans rs6104690 1.000 rs6104690 chr20:10988099 G/A cg07172334 chr21:31655261 KRTAP24-1 -0.33 -5.94 -0.31 6.99e-9 Bladder cancer; LUSC cis rs4780401 0.609 rs4781142 chr16:11808806 T/C cg01061890 chr16:11836724 TXNDC11 -0.56 -8.63 -0.43 2.52e-16 Rheumatoid arthritis; LUSC cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg15605315 chr1:45957053 TESK2 -0.44 -6.77 -0.35 5.74e-11 High light scatter reticulocyte count; LUSC cis rs4285028 0.948 rs1920309 chr3:121665479 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.78 -0.47 5.11e-20 Multiple sclerosis; LUSC cis rs453301 0.652 rs2043129 chr8:8825504 C/G cg06636001 chr8:8085503 FLJ10661 0.48 7.36 0.37 1.44e-12 Joint mobility (Beighton score); LUSC cis rs34375054 0.641 rs34624329 chr12:125608028 T/G cg09839279 chr12:125627357 AACS -0.33 -6.09 -0.32 3.03e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7189233 0.531 rs9302648 chr16:53527781 G/T cg09728985 chr16:53543985 NA -0.31 -5.8 -0.3 1.55e-8 Intelligence (multi-trait analysis); LUSC cis rs525592 1 rs525592 chr11:68195104 C/T cg16797656 chr11:68205561 LRP5 0.47 8.38 0.42 1.48e-15 Bone mineral density; LUSC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg09085632 chr11:111637200 PPP2R1B -1.07 -17.63 -0.69 1.25e-49 Primary sclerosing cholangitis; LUSC trans rs60843830 0.633 rs1078763 chr2:113763 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.54 -8.66 -0.43 2e-16 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg13256891 chr4:100009986 ADH5 0.49 7.3 0.37 2.18e-12 Alcohol dependence; LUSC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg08968635 chr6:28129556 ZNF389 0.44 5.65 0.3 3.38e-8 Parkinson's disease; LUSC cis rs7267979 1.000 rs2500424 chr20:25391969 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.81 -17.26 -0.69 3.73e-48 Liver enzyme levels (alkaline phosphatase); LUSC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg13206674 chr6:150067644 NUP43 0.41 6.34 0.33 7.49e-10 Testicular germ cell tumor; LUSC cis rs7937682 0.924 rs10891284 chr11:111527737 T/C cg22437258 chr11:111473054 SIK2 0.5 6.89 0.35 2.78e-11 Primary sclerosing cholangitis; LUSC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg17143192 chr8:8559678 CLDN23 0.64 9.33 0.45 1.54e-18 Obesity-related traits; LUSC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg08859206 chr1:53392774 SCP2 -0.69 -13.17 -0.58 3.29e-32 Monocyte count; LUSC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg07703079 chr11:430292 ANO9 0.63 6.88 0.35 2.92e-11 Body mass index; LUSC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg14552801 chr7:65878734 NA 0.39 5.97 0.31 6.13e-9 Aortic root size; LUSC cis rs7582720 1.000 rs72934711 chr2:203709997 G/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.73 8.0 0.4 2.12e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs2294693 0.947 rs736793 chr6:40997919 A/T cg14769373 chr6:40998127 UNC5CL -0.56 -8.04 -0.4 1.54e-14 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -7.89 -0.4 4.31e-14 Allergic disease (asthma, hay fever or eczema); LUSC cis rs921968 0.565 rs6757772 chr2:219618497 T/G cg02176678 chr2:219576539 TTLL4 -0.57 -10.14 -0.48 3.18e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs807669 0.505 rs8142503 chr22:19166717 G/T cg02655711 chr22:19163373 SLC25A1 0.53 9.49 0.46 4.4e-19 Metabolite levels; LUSC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.79 0.35 5.13e-11 Tonsillectomy; LUSC cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg26384229 chr12:38710491 ALG10B 0.89 14.86 0.63 1.09e-38 Drug-induced liver injury (flucloxacillin); LUSC cis rs9420 0.961 rs708228 chr11:57585662 C/T cg02958346 chr11:57425731 CLP1 -0.43 -6.22 -0.32 1.5e-9 Schizophrenia; LUSC cis rs12973672 1.000 rs12975284 chr19:35770962 G/C cg12095397 chr19:35769544 USF2 0.44 6.91 0.35 2.42e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg18806716 chr10:30721971 MAP3K8 -0.61 -9.89 -0.48 2.13e-20 Inflammatory bowel disease; LUSC cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg19875535 chr5:140030758 IK -0.54 -8.9 -0.44 3.63e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -7.03 -0.36 1.18e-11 Monocyte percentage of white cells; LUSC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg03929089 chr4:120376271 NA -1.04 -20.21 -0.74 7.12e-60 Height; LUSC cis rs9929218 1.000 rs9929218 chr16:68820946 G/A cg02972257 chr16:68554789 NA 0.41 5.73 0.3 2.19e-8 Colorectal cancer; LUSC cis rs9300255 0.510 rs1790109 chr12:123637752 C/G cg00376283 chr12:123451042 ABCB9 0.67 8.44 0.42 9.73e-16 Neutrophil percentage of white cells; LUSC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg13607699 chr17:42295918 UBTF 0.55 8.38 0.42 1.46e-15 Total body bone mineral density; LUSC cis rs17095355 1.000 rs57440982 chr10:111735772 G/A cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.48 -0.38 6.7e-13 Biliary atresia; LUSC cis rs713587 0.521 rs35177510 chr2:25089594 C/A cg15423357 chr2:25149977 NA 0.37 7.19 0.37 4.31e-12 Body mass index in non-asthmatics; LUSC trans rs10435719 0.773 rs7842810 chr8:11794163 A/G cg14343924 chr8:8086146 FLJ10661 0.45 6.19 0.32 1.76e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs34638657 0.827 rs2303262 chr16:82203758 C/T cg09439754 chr16:82129088 HSD17B2 -0.41 -6.28 -0.32 1.06e-9 Lung adenocarcinoma; LUSC cis rs7954584 0.616 rs10743186 chr12:122356436 C/T cg21016266 chr12:122356598 WDR66 0.54 7.68 0.39 1.82e-13 Mean corpuscular volume; LUSC trans rs1998174 0.509 rs2901600 chr1:171835654 G/A cg13482142 chr2:234261155 NA 0.42 6.13 0.32 2.46e-9 Platelet distribution width; LUSC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg25039879 chr17:56429692 SUPT4H1 0.67 8.85 0.44 5.03e-17 Cognitive test performance; LUSC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg19622623 chr12:86230825 RASSF9 0.44 6.29 0.33 1.02e-9 Major depressive disorder; LUSC cis rs13256369 0.950 rs13255655 chr8:8577736 C/T cg06671706 chr8:8559999 CLDN23 0.49 6.27 0.32 1.09e-9 Obesity-related traits; LUSC cis rs4462272 0.554 rs2862946 chr10:101862648 G/A cg02250046 chr10:101825185 CPN1 -0.33 -6.06 -0.31 3.57e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg07741184 chr6:167504864 NA -0.36 -6.53 -0.34 2.41e-10 Crohn's disease; LUSC cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg03146154 chr1:46216737 IPP 0.5 7.54 0.38 4.48e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9660992 0.674 rs72745219 chr1:205262271 G/A cg21545522 chr1:205238299 TMCC2 0.5 9.45 0.46 5.97e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs7119 0.717 rs12898370 chr15:77808598 A/T cg27398640 chr15:77910606 LINGO1 -0.29 -6.32 -0.33 8.41e-10 Type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18807030 chr7:931980 C7orf20 -0.72 -6.09 -0.32 3.04e-9 Cognitive performance; LUSC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg19717773 chr7:2847554 GNA12 -0.39 -6.2 -0.32 1.69e-9 Height; LUSC cis rs12368653 0.641 rs11172300 chr12:58076515 C/T cg12615879 chr12:58013172 SLC26A10 0.38 8.71 0.43 1.4e-16 Multiple sclerosis; LUSC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg05528280 chr10:464225 DIP2C 0.4 6.19 0.32 1.76e-9 Psychosis in Alzheimer's disease; LUSC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg11062466 chr8:58055876 NA 0.77 8.64 0.43 2.42e-16 Developmental language disorder (linguistic errors); LUSC cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg00484396 chr16:3507460 NAT15 0.47 7.0 0.36 1.42e-11 Body mass index (adult); LUSC cis rs10752881 1.000 rs4233193 chr1:182970865 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 10.32 0.49 7.37e-22 Colorectal cancer; LUSC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg23711669 chr6:146136114 FBXO30 0.88 16.13 0.66 1.12e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg08999081 chr20:33150536 PIGU 0.37 6.67 0.34 1.08e-10 Height; LUSC trans rs11992162 0.636 rs13265816 chr8:11797485 G/A cg06636001 chr8:8085503 FLJ10661 0.46 6.37 0.33 6.32e-10 Monocyte count; LUSC cis rs7011049 0.908 rs72640866 chr8:53843014 C/T cg26025543 chr8:53854495 NA 0.52 6.3 0.33 9.5e-10 Systolic blood pressure; LUSC cis rs79839061 0.610 rs73207794 chr4:872020 T/C cg07828340 chr4:882639 GAK 1.05 11.18 0.52 7.56e-25 Intelligence (multi-trait analysis); LUSC cis rs10266483 0.774 rs10949894 chr7:63800521 C/A cg24201672 chr7:64023550 ZNF680 0.44 5.8 0.3 1.53e-8 Response to statin therapy; LUSC cis rs41271951 0.512 rs12074309 chr1:151087827 T/C cg11822372 chr1:151115635 SEMA6C -0.76 -6.95 -0.36 1.98e-11 Blood protein levels; LUSC cis rs733592 0.507 rs10875739 chr12:48480919 C/T cg24011408 chr12:48396354 COL2A1 0.49 8.14 0.41 8.04e-15 Plateletcrit; LUSC cis rs4363385 0.667 rs11803197 chr1:152934420 G/A cg07796016 chr1:152779584 LCE1C -0.43 -6.03 -0.31 4.23e-9 Inflammatory skin disease; LUSC cis rs9921338 0.887 rs9926136 chr16:11437275 A/G cg00044050 chr16:11439710 C16orf75 -0.51 -6.79 -0.35 5.18e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg16743903 chr16:89593216 SPG7 -0.47 -6.5 -0.34 2.9e-10 Multiple myeloma (IgH translocation); LUSC cis rs7927592 0.913 rs67947146 chr11:68314980 C/T cg16797656 chr11:68205561 LRP5 0.38 6.23 0.32 1.4e-9 Total body bone mineral density; LUSC trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg15704280 chr7:45808275 SEPT13 0.73 8.39 0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs8028313 0.630 rs7169086 chr15:67934454 C/T cg05925327 chr15:68127851 NA -0.43 -6.74 -0.35 7.01e-11 Obesity; LUSC cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 20.5 0.75 4.82e-61 Cognitive ability; LUSC cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 12.81 0.57 7.77e-31 Chronic sinus infection; LUSC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg08219700 chr8:58056026 NA 0.68 8.19 0.41 5.59e-15 Developmental language disorder (linguistic errors); LUSC cis rs2414856 0.510 rs72756988 chr15:64597636 C/T cg08069370 chr15:64387884 SNX1 -0.77 -6.53 -0.34 2.44e-10 Pulse pressure;Systolic blood pressure; LUSC cis rs7100689 0.622 rs2994389 chr10:82062257 C/G cg01528321 chr10:82214614 TSPAN14 0.83 12.44 0.56 1.93e-29 Post bronchodilator FEV1; LUSC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg09034736 chr1:150693464 HORMAD1 0.44 6.16 0.32 2.05e-9 Melanoma; LUSC cis rs929596 0.564 rs2741038 chr2:234563998 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -6.03 -0.31 4.27e-9 Total bilirubin levels in HIV-1 infection; LUSC cis rs11955175 1.000 rs11956743 chr5:40677593 G/A cg05478818 chr5:40835740 RPL37 0.7 5.77 0.3 1.81e-8 Bipolar disorder and schizophrenia; LUSC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.83 0.39 6.38e-14 Parkinson's disease; LUSC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg24011408 chr12:48396354 COL2A1 -0.4 -5.73 -0.3 2.26e-8 Glycated hemoglobin levels; LUSC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg16339924 chr4:17578868 LAP3 0.55 8.41 0.42 1.18e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg00945038 chr17:61921165 SMARCD2 0.55 9.25 0.45 2.73e-18 Prudent dietary pattern; LUSC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.2 0.32 1.69e-9 Schizophrenia; LUSC cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg16386425 chr10:429943 DIP2C -0.44 -6.97 -0.36 1.65e-11 Psychosis in Alzheimer's disease; LUSC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.87 -12.37 -0.56 3.29e-29 Platelet count; LUSC cis rs3820068 0.608 rs6668919 chr1:16049893 A/G cg24675056 chr1:15929824 NA -0.4 -6.75 -0.35 6.71e-11 Systolic blood pressure; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg13395646 chr4:1353034 KIAA1530 -0.62 -10.07 -0.48 5.08e-21 Obesity-related traits; LUSC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg06808227 chr14:105710500 BRF1 -0.64 -9.68 -0.47 1.06e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg09034736 chr1:150693464 HORMAD1 0.43 6.2 0.32 1.71e-9 Melanoma; LUSC cis rs34779708 0.966 rs12765038 chr10:35416513 G/C cg03585969 chr10:35415529 CREM 0.61 9.08 0.44 9.76e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg02951883 chr7:2050386 MAD1L1 0.55 10.14 0.49 3.12e-21 Bipolar disorder and schizophrenia; LUSC cis rs59698941 0.943 rs66480446 chr5:132274793 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 6.9e-10 Apolipoprotein A-IV levels; LUSC cis rs2303282 0.690 rs869205 chr16:56394035 T/C cg00500540 chr16:56394104 NA -0.44 -7.59 -0.38 3.3e-13 Breast cancer; LUSC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg26587870 chr6:27730563 NA -0.52 -6.06 -0.31 3.75e-9 Depression; LUSC cis rs9300255 0.663 rs7953929 chr12:123758235 C/G cg13010344 chr12:123464640 ARL6IP4 -0.51 -6.27 -0.32 1.13e-9 Neutrophil percentage of white cells; LUSC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg21285383 chr16:89894308 SPIRE2 0.35 7.45 0.38 8.16e-13 Vitiligo; LUSC trans rs7615952 0.599 rs2333408 chr3:125732098 G/A cg07211511 chr3:129823064 LOC729375 -0.82 -11.83 -0.54 3.19e-27 Blood pressure (smoking interaction); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg00611675 chr8:128748464 MYC 0.49 6.01 0.31 4.82e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg22105103 chr4:187893119 NA 0.72 13.95 0.61 3.66e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg07741184 chr6:167504864 NA -0.35 -6.42 -0.33 4.78e-10 Crohn's disease; LUSC cis rs4363385 0.553 rs41263664 chr1:152974063 G/A cg00922841 chr1:152955080 SPRR1A -0.38 -6.48 -0.33 3.3e-10 Inflammatory skin disease; LUSC trans rs7922314 1.000 rs61865883 chr10:64572680 A/T cg00459623 chr2:176936581 NA -0.48 -6.13 -0.32 2.52e-9 Cutaneous psoriasis; LUSC trans rs61931739 0.534 rs7313137 chr12:34010231 T/G cg26384229 chr12:38710491 ALG10B 0.72 11.29 0.53 3.03e-25 Morning vs. evening chronotype; LUSC cis rs9323205 0.677 rs12587080 chr14:51723079 A/C cg23942311 chr14:51606299 NA -0.39 -7.25 -0.37 2.92e-12 Cancer; LUSC cis rs7904368 0.659 rs3740169 chr10:16873547 C/T cg23933602 chr10:16859644 RSU1 0.63 8.74 0.43 1.19e-16 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg13395646 chr4:1353034 KIAA1530 0.55 8.38 0.42 1.54e-15 Obesity-related traits; LUSC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg12751644 chr20:60527061 NA -0.34 -6.0 -0.31 5.03e-9 Body mass index; LUSC trans rs9693857 1.000 rs9693857 chr8:9267117 C/T cg21775007 chr8:11205619 TDH -0.48 -6.68 -0.34 9.82e-11 Systolic blood pressure; LUSC cis rs2976388 1.000 rs2920293 chr8:143765414 C/G cg17252645 chr8:143867129 LY6D -0.37 -6.4 -0.33 5.13e-10 Urinary tract infection frequency; LUSC cis rs58688157 0.960 rs1051390 chr11:613165 G/C cg14433983 chr11:636460 DRD4 -0.35 -5.88 -0.31 9.78e-9 Systemic lupus erythematosus; LUSC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg07211511 chr3:129823064 LOC729375 -1.24 -20.36 -0.74 1.75e-60 Blood pressure (smoking interaction); LUSC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg08270630 chr22:50330655 NA 0.41 6.24 0.32 1.34e-9 Schizophrenia; LUSC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg17971929 chr21:40555470 PSMG1 0.79 13.89 0.6 6.34e-35 Cognitive function; LUSC cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 6.95 0.36 1.97e-11 Rheumatoid arthritis; LUSC trans rs11039798 0.764 rs7294013 chr11:48762416 G/A cg03929089 chr4:120376271 NA 0.74 6.91 0.35 2.4e-11 Axial length; LUSC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg17554472 chr22:41940697 POLR3H 0.48 5.91 0.31 8.32e-9 Vitiligo; LUSC cis rs929596 0.501 rs4530361 chr2:234590041 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -6.55 -0.34 2.23e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs9612 1.000 rs58896392 chr19:44269142 G/A cg08581076 chr19:44259116 C19orf61 0.47 5.7 0.3 2.69e-8 Exhaled nitric oxide output; LUSC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg13939156 chr17:80058883 NA 0.34 6.57 0.34 1.97e-10 Life satisfaction; LUSC cis rs11645898 0.872 rs34832584 chr16:72162966 G/T cg14768367 chr16:72042858 DHODH -0.65 -7.15 -0.36 5.63e-12 Blood protein levels; LUSC cis rs977987 0.778 rs4243112 chr16:75321031 T/C cg04384234 chr16:75411784 CFDP1 -0.38 -6.0 -0.31 5.04e-9 Dupuytren's disease; LUSC cis rs909674 0.662 rs2899318 chr22:39837625 A/G cg05872129 chr22:39784769 NA -0.58 -9.83 -0.47 3.47e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs3849570 1.000 rs9818006 chr3:81828230 A/C cg07356753 chr3:81810745 GBE1 -0.58 -9.2 -0.45 3.93e-18 Waist circumference;Body mass index; LUSC cis rs1008375 1.000 rs10939743 chr4:17662731 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.71 0.34 8.1e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg03060546 chr3:49711283 APEH -0.69 -10.12 -0.48 3.6e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs5769707 0.740 rs79946167 chr22:50017556 G/A cg01652190 chr22:50026171 C22orf34 -0.28 -5.69 -0.3 2.83e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs708547 0.647 rs6843644 chr4:57891239 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 7.66 0.39 1.98e-13 Response to bleomycin (chromatid breaks); LUSC cis rs1507153 0.673 rs9361414 chr6:79345448 G/T cg05283184 chr6:79620031 NA -0.42 -7.33 -0.37 1.74e-12 Sjögren's syndrome; LUSC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.765 rs2278895 chr2:99613484 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.17 -0.41 6.51e-15 Chronic sinus infection; LUSC cis rs2742417 0.603 rs2253979 chr3:45773320 A/G cg10512202 chr3:45649293 LIMD1 0.36 5.94 0.31 7.3e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg13770153 chr20:60521292 NA 1.0 15.0 0.63 3.09e-39 Obesity-related traits; LUSC cis rs992157 0.697 rs13384682 chr2:219069137 G/A cg00012203 chr2:219082015 ARPC2 0.87 16.56 0.67 2.26e-45 Colorectal cancer; LUSC cis rs2274273 0.624 rs12050123 chr14:55840386 G/A cg04306507 chr14:55594613 LGALS3 0.49 9.94 0.48 1.47e-20 Protein biomarker; LUSC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs1979679 0.573 rs7316056 chr12:28728676 A/G cg13890972 chr12:28721907 NA -0.41 -6.0 -0.31 5.13e-9 Ossification of the posterior longitudinal ligament of the spine; LUSC cis rs9837602 1.000 rs35521705 chr3:99716690 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.17 0.32 1.96e-9 Breast cancer; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg16142952 chr22:24129598 SMARCB1 0.4 6.27 0.32 1.11e-9 Triglycerides; LUSC cis rs477692 0.935 rs568918 chr10:131414455 A/G cg05714579 chr10:131428358 MGMT 0.53 8.05 0.4 1.52e-14 Response to temozolomide; LUSC cis rs13064411 0.696 rs6438156 chr3:113206929 C/A cg18753928 chr3:113234510 CCDC52 -0.54 -8.23 -0.41 4.16e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7106204 0.748 rs4636667 chr11:24238615 T/C ch.11.24196551F chr11:24239977 NA 1.17 14.66 0.63 6.73e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg05084668 chr3:125655381 ALG1L -0.52 -7.95 -0.4 2.82e-14 Blood pressure (smoking interaction); LUSC cis rs17227506 0.630 rs67670052 chr8:13443474 G/C cg03566418 chr8:13424080 C8orf48 0.42 6.34 0.33 7.58e-10 Nonsyndromic cleft lip with cleft palate; LUSC cis rs7197653 0.519 rs55757091 chr16:68323654 G/A cg09835421 chr16:68378352 PRMT7 -0.58 -6.69 -0.34 9.26e-11 Magnesium levels; LUSC cis rs11250098 0.642 rs4841460 chr8:10789493 C/G cg27411982 chr8:10470053 RP1L1 -0.49 -7.32 -0.37 1.83e-12 Morning vs. evening chronotype; LUSC cis rs2204008 0.837 rs7301679 chr12:37989629 T/C cg13010199 chr12:38710504 ALG10B -0.61 -9.54 -0.46 3.15e-19 Bladder cancer; LUSC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg19774624 chr17:42201019 HDAC5 -0.81 -13.38 -0.59 5.26e-33 Total body bone mineral density; LUSC cis rs11792861 0.926 rs17729523 chr9:111773317 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.6 9.0 0.44 1.79e-17 Menarche (age at onset); LUSC cis rs77633900 0.502 rs116917406 chr15:76922940 T/C cg21673338 chr15:77095150 SCAPER -0.71 -5.98 -0.31 5.72e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg07606381 chr6:8435919 SLC35B3 0.72 12.19 0.55 1.55e-28 Motion sickness; LUSC cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg24692254 chr21:30365293 RNF160 -0.79 -14.31 -0.62 1.5e-36 Dental caries; LUSC cis rs523522 1.000 rs523522 chr12:121020250 A/T cg12219531 chr12:120966889 COQ5 0.64 8.7 0.43 1.51e-16 High light scatter reticulocyte count; LUSC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg27170947 chr2:26402098 FAM59B -0.69 -10.55 -0.5 1.2e-22 Gut microbiome composition (summer); LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs400736 0.894 rs225092 chr1:8036075 G/C cg25007680 chr1:8021821 PARK7 0.59 9.32 0.45 1.69e-18 Response to antidepressants and depression; LUSC trans rs7613875 0.580 rs12634780 chr3:50043341 A/T cg21659725 chr3:3221576 CRBN -0.49 -7.8 -0.39 8.26e-14 Body mass index; LUSC cis rs6977660 1.000 rs5017194 chr7:19820035 A/T cg07541023 chr7:19748670 TWISTNB 0.51 5.7 0.3 2.6e-8 Thyroid stimulating hormone; LUSC cis rs4947962 0.525 rs28573307 chr7:55148816 C/T cg23757825 chr7:55092271 EGFR -0.46 -5.78 -0.3 1.7e-8 Subjective response to lithium treatment; LUSC cis rs16854884 0.586 rs4616638 chr3:143735423 A/T cg06585982 chr3:143692056 C3orf58 -0.51 -8.58 -0.42 3.75e-16 Economic and political preferences (feminism/equality); LUSC cis rs4343996 0.521 rs12667184 chr7:3413793 A/G cg21248987 chr7:3385318 SDK1 0.34 5.75 0.3 1.99e-8 Motion sickness; LUSC cis rs7568458 0.870 rs1009 chr2:85808737 A/G cg17127132 chr2:85788382 GGCX 0.46 7.42 0.38 9.82e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs6987853 0.931 rs2923444 chr8:42397004 C/T cg09913449 chr8:42400586 C8orf40 0.49 8.26 0.41 3.35e-15 Mean corpuscular hemoglobin concentration; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg15340874 chr1:174969621 CACYBP -0.42 -6.08 -0.32 3.21e-9 Electrocardiographic conduction measures; LUSC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.97 0.4 2.6e-14 Prudent dietary pattern; LUSC cis rs968451 0.762 rs5757618 chr22:39724551 A/T cg17798944 chr22:39715225 SNORD43;RPL3 0.66 8.7 0.43 1.5e-16 Primary biliary cholangitis; LUSC cis rs9287719 0.967 rs3814388 chr2:10702099 A/T cg00105475 chr2:10696890 NA 0.37 6.12 0.32 2.55e-9 Prostate cancer; LUSC cis rs12946454 0.668 rs4792867 chr17:43249444 C/T cg10701640 chr17:43249399 NA 0.52 12.37 0.56 3.47e-29 Systolic blood pressure; LUSC cis rs3772130 0.962 rs6784571 chr3:121539991 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.68 10.13 0.48 3.31e-21 Cognitive performance; LUSC cis rs9790314 1.000 rs4370045 chr3:160943865 A/G cg03342759 chr3:160939853 NMD3 -0.52 -8.91 -0.44 3.4e-17 Morning vs. evening chronotype; LUSC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg15147215 chr3:52552868 STAB1 -0.33 -6.44 -0.33 4.06e-10 Electroencephalogram traits; LUSC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg15145296 chr3:125709740 NA -0.56 -6.21 -0.32 1.58e-9 Blood pressure (smoking interaction); LUSC cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg11189052 chr15:85197271 WDR73 -0.42 -6.29 -0.33 1.02e-9 P wave terminal force; LUSC cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg13319975 chr6:146136371 FBXO30 -0.47 -7.01 -0.36 1.29e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg22782873 chr19:19639568 YJEFN3 0.5 6.07 0.32 3.52e-9 Bipolar disorder; LUSC trans rs4773505 0.745 rs4988951 chr13:90429775 T/G cg07142010 chr1:21901166 ALPL -0.31 -5.95 -0.31 6.9e-9 Loneliness (multivariate analysis); LUSC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg11764359 chr7:65958608 NA 0.79 12.96 0.58 2.05e-31 Aortic root size; LUSC cis rs28829049 0.597 rs2313509 chr1:19437860 C/T cg13387374 chr1:19411106 UBR4 0.42 5.78 0.3 1.71e-8 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs12908161 1.000 rs12899981 chr15:85302373 G/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.66 0.34 1.15e-10 Schizophrenia; LUSC trans rs11722228 0.508 rs73212864 chr4:10104191 G/A cg26043149 chr18:55253948 FECH 0.98 14.97 0.63 4.11e-39 Gout;Urate levels;Serum uric acid levels; LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg13047869 chr3:10149882 C3orf24 0.63 9.07 0.44 1.02e-17 Alzheimer's disease; LUSC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs2639990 1.000 rs609303 chr18:72895242 C/T cg11568697 chr18:72916393 ZADH2 0.54 6.4 0.33 5.11e-10 Vascular endothelial growth factor levels; LUSC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.9 14.8 0.63 1.84e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg27211696 chr2:191398769 TMEM194B 0.6 11.62 0.54 1.88e-26 Pulse pressure; LUSC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg24812749 chr6:127587940 RNF146 0.84 12.34 0.56 4.25e-29 Breast cancer; LUSC cis rs6076065 0.723 rs4815203 chr20:23395633 C/G cg11657817 chr20:23433608 CST11 0.44 8.22 0.41 4.64e-15 Facial morphology (factor 15, philtrum width); LUSC trans rs61931739 0.517 rs11513519 chr12:34075077 G/A cg26384229 chr12:38710491 ALG10B 0.72 11.37 0.53 1.52e-25 Morning vs. evening chronotype; LUSC cis rs7179456 0.547 rs6494035 chr15:59015888 C/G cg05156742 chr15:59063176 FAM63B 0.5 7.23 0.37 3.38e-12 Asperger disorder; LUSC cis rs6933660 0.744 rs3800279 chr6:151766162 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.42 5.66 0.3 3.23e-8 Menarche (age at onset); LUSC cis rs9399401 0.884 rs263180 chr6:142862768 C/A cg03128060 chr6:142623767 GPR126 0.32 6.03 0.31 4.36e-9 Chronic obstructive pulmonary disease; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24465448 chr8:17942444 ASAH1 0.4 5.95 0.31 6.64e-9 Triglycerides; LUSC cis rs17373728 0.710 rs12544686 chr8:76218074 C/T cg07016329 chr8:76221503 NA -0.46 -6.69 -0.34 9.27e-11 Diabetic kidney disease; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13126279 chr21:47581558 C21orf56 0.52 7.99 0.4 2.26e-14 Testicular germ cell tumor; LUSC cis rs713477 0.967 rs11158039 chr14:55906696 A/T cg13175173 chr14:55914753 NA -0.32 -6.72 -0.35 7.95e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg20503657 chr10:835505 NA 0.85 12.07 0.55 4.45e-28 Eosinophil percentage of granulocytes; LUSC trans rs11088226 0.681 rs2833902 chr21:33940458 A/G cg09050820 chr6:167586206 TCP10L2 0.74 9.61 0.47 1.89e-19 Gastritis; LUSC cis rs6693567 0.565 rs12093148 chr1:150265173 G/A cg09579323 chr1:150459698 TARS2 -0.43 -6.0 -0.31 5.03e-9 Migraine; LUSC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg03806693 chr22:41940476 POLR3H 0.97 13.69 0.6 3.61e-34 Vitiligo; LUSC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.28 -7.29 -0.37 2.21e-12 Lymphocyte counts; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg18187865 chr6:34857018 ANKS1A;TAF11 -0.41 -6.3 -0.33 9.63e-10 Electrocardiographic conduction measures; LUSC cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg26647111 chr11:31128758 NA -0.41 -6.03 -0.31 4.44e-9 Red blood cell count; LUSC cis rs11105298 0.891 rs11105302 chr12:89891366 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 0.51 7.23 0.37 3.26e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1568889 0.838 rs11030206 chr11:28099747 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.71 0.57 1.8e-30 Bipolar disorder; LUSC cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -7.21 -0.37 3.8e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg18681998 chr4:17616180 MED28 0.89 15.6 0.65 1.34e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.46 6.11 0.32 2.79e-9 Renal function-related traits (BUN); LUSC cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg21252483 chr19:49399788 TULP2 -0.48 -6.77 -0.35 5.81e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg03264133 chr6:25882463 NA 0.61 10.19 0.49 2.08e-21 Blood metabolite levels; LUSC cis rs250677 0.652 rs36042 chr5:148439782 G/T cg12140854 chr5:148520817 ABLIM3 -0.42 -6.14 -0.32 2.38e-9 Breast cancer; LUSC cis rs35110281 0.626 rs10854486 chr21:45118280 G/T cg04455712 chr21:45112962 RRP1B 0.45 8.36 0.42 1.69e-15 Mean corpuscular volume; LUSC cis rs4953076 0.573 rs67537903 chr2:44422111 G/A cg04920474 chr2:44395004 PPM1B 0.66 8.33 0.41 2.1e-15 Height; LUSC cis rs5770917 1.000 rs12627787 chr22:51012381 C/T cg27502912 chr22:51017001 CPT1B;CHKB-CPT1B -0.65 -5.7 -0.3 2.7e-8 Narcolepsy; LUSC cis rs7264396 0.563 rs2425109 chr20:34316218 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.49 -0.42 6.89e-16 Total cholesterol levels; LUSC cis rs6977660 1.000 rs5017196 chr7:19819983 T/C cg07541023 chr7:19748670 TWISTNB 0.51 5.7 0.3 2.6e-8 Thyroid stimulating hormone; LUSC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9467773 0.620 rs2504592 chr6:26640951 C/G cg11502198 chr6:26597334 ABT1 0.72 12.07 0.55 4.23e-28 Intelligence (multi-trait analysis); LUSC cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg06784218 chr1:46089804 CCDC17 -0.47 -9.14 -0.45 6.34e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2236918 1.000 rs735943 chr1:242030151 C/T cg17736920 chr1:242011382 EXO1 -0.43 -6.75 -0.35 6.37e-11 Menopause (age at onset); LUSC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg08508325 chr11:3079039 CARS -0.5 -11.48 -0.53 6.06e-26 Longevity; LUSC trans rs2243480 1.000 rs6964245 chr7:65718717 G/A cg10756647 chr7:56101905 PSPH -0.86 -8.46 -0.42 8.51e-16 Diabetic kidney disease; LUSC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg05347473 chr6:146136440 FBXO30 0.54 9.33 0.45 1.51e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs3764563 1.000 rs623675 chr19:15705115 G/A cg20725493 chr19:15740067 CYP4F8 0.67 6.55 0.34 2.2e-10 Inflammatory biomarkers; LUSC trans rs11039798 0.512 rs11040205 chr11:49007360 G/C cg15704280 chr7:45808275 SEPT13 0.76 8.47 0.42 8.13e-16 Axial length; LUSC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg06263672 chr7:65235340 NA -0.44 -6.46 -0.33 3.61e-10 Calcium levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg15878588 chr22:38203858 GCAT -0.42 -6.42 -0.33 4.76e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3784262 0.607 rs4646576 chr15:58338998 A/T cg12031962 chr15:58353849 ALDH1A2 -0.39 -7.0 -0.36 1.39e-11 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs4494114 0.875 rs7518432 chr1:39363522 G/C cg25970120 chr1:39325951 RRAGC -0.4 -6.22 -0.32 1.49e-9 Blood protein levels; LUSC cis rs62400317 0.859 rs11965706 chr6:45141441 T/A cg18551225 chr6:44695536 NA -0.43 -6.92 -0.35 2.37e-11 Total body bone mineral density; LUSC trans rs7647973 0.593 rs28535523 chr3:49848414 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.61 7.26 0.37 2.72e-12 Menarche (age at onset); LUSC cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.69 0.83 1.71e-88 Chronic sinus infection; LUSC cis rs721399 0.553 rs10095072 chr8:18244662 G/T cg18736775 chr8:18248649 NAT2 -0.55 -6.57 -0.34 1.88e-10 Blood metabolite levels; LUSC cis rs7192380 1.000 rs2161630 chr16:69606461 C/T cg26679644 chr16:69762563 NA 0.36 6.21 0.32 1.61e-9 Sjögren's syndrome; LUSC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg09904177 chr6:26538194 HMGN4 0.47 7.48 0.38 6.76e-13 Schizophrenia; LUSC cis rs4961252 0.505 rs12680168 chr8:142102522 A/T cg09914555 chr8:142094789 NA -0.48 -7.18 -0.37 4.52e-12 Isovolumetric relaxation time;Response to interferon beta therapy; LUSC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg00701064 chr4:6280414 WFS1 0.47 8.34 0.42 1.91e-15 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg21724239 chr8:58056113 NA 0.56 6.86 0.35 3.37e-11 Developmental language disorder (linguistic errors); LUSC cis rs7923837 0.656 rs2497306 chr10:94485211 A/C cg25093409 chr10:94429542 NA -0.35 -6.0 -0.31 5.16e-9 Body mass index;Multiple sclerosis; LUSC cis rs473651 0.740 rs502349 chr2:239318389 C/T cg08773314 chr2:239334832 ASB1 0.39 8.26 0.41 3.49e-15 Multiple system atrophy; LUSC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg22815214 chr1:201083145 CACNA1S 0.6 10.44 0.5 2.77e-22 Permanent tooth development; LUSC cis rs7072216 0.922 rs10786415 chr10:100151266 A/G cg26618903 chr10:100175079 PYROXD2 -0.3 -5.95 -0.31 6.89e-9 Metabolite levels; LUSC cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg00071950 chr4:10020882 SLC2A9 0.47 7.69 0.39 1.63e-13 Bone mineral density; LUSC cis rs3820068 0.608 rs12760450 chr1:16037282 G/A cg24675056 chr1:15929824 NA 0.41 6.83 0.35 4.07e-11 Systolic blood pressure; LUSC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg27284194 chr4:1044797 NA 0.37 5.98 0.31 5.75e-9 Longevity; LUSC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg23982607 chr1:1823379 GNB1 0.35 5.85 0.3 1.18e-8 Body mass index; LUSC trans rs3942852 0.568 rs7479361 chr11:48109793 C/T cg15704280 chr7:45808275 SEPT13 -0.62 -8.23 -0.41 4.19e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg08859206 chr1:53392774 SCP2 0.5 8.58 0.43 3.56e-16 Monocyte count; LUSC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg03264133 chr6:25882463 NA -0.6 -9.93 -0.48 1.56e-20 Intelligence (multi-trait analysis); LUSC cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.85 -0.58 5.7e-31 Chronic sinus infection; LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg02475777 chr4:1388615 CRIPAK 0.44 6.58 0.34 1.84e-10 Obesity-related traits; LUSC cis rs911555 0.504 rs4444269 chr14:104072724 G/C cg24130564 chr14:104152367 KLC1 -0.7 -11.17 -0.52 7.85e-25 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18788872 chr11:32605728 EIF3M 0.46 6.4 0.33 5.35e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg08888203 chr3:10149979 C3orf24 -0.42 -6.44 -0.33 4.12e-10 Alzheimer's disease; LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg11062466 chr8:58055876 NA 0.76 9.04 0.44 1.31e-17 Developmental language disorder (linguistic errors); LUSC cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg02153584 chr22:29168773 CCDC117 0.58 8.72 0.43 1.35e-16 Lymphocyte counts; LUSC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg22590775 chr19:49891494 CCDC155 0.57 7.4 0.38 1.09e-12 Multiple sclerosis; LUSC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg05585544 chr11:47624801 NA 0.41 7.19 0.37 4.39e-12 Subjective well-being; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.1 0.52 1.39e-24 Alzheimer's disease; LUSC cis rs116988415 0.584 rs78707026 chr14:65249283 A/G cg00114569 chr14:65239327 SPTB 0.63 6.92 0.35 2.28e-11 Daytime sleep phenotypes; LUSC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03352830 chr11:487213 PTDSS2 0.74 8.84 0.44 5.65e-17 Body mass index; LUSC cis rs10644111 1 rs10644111 chr7:91652178 A/AAAC cg17063962 chr7:91808500 NA 0.57 9.07 0.44 1.02e-17 Breast cancer; LUSC cis rs950169 0.649 rs12905952 chr15:84691261 G/A cg12863693 chr15:85201151 NMB 0.37 6.88 0.35 2.97e-11 Schizophrenia; LUSC cis rs1348850 0.668 rs12618542 chr2:178494520 A/G cg22681709 chr2:178499509 PDE11A -0.53 -8.28 -0.41 3.04e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg06618935 chr21:46677482 NA -0.35 -6.79 -0.35 5.25e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2404602 0.684 rs2047504 chr15:76883516 A/T cg23625390 chr15:77176239 SCAPER -0.67 -10.37 -0.49 5.18e-22 Blood metabolite levels; LUSC trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg03929089 chr4:120376271 NA 0.69 7.78 0.39 9.14e-14 Acute lymphoblastic leukemia (childhood); LUSC cis rs4845570 1.000 rs6683364 chr1:151746202 T/A cg07092448 chr1:151763213 TDRKH -1.27 -14.41 -0.62 5.93e-37 Coronary artery disease; LUSC trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg03929089 chr4:120376271 NA -0.45 -6.12 -0.32 2.58e-9 HDL cholesterol; LUSC cis rs500891 1.000 rs36017560 chr6:84181468 T/C cg08257003 chr6:84140564 ME1 0.34 7.02 0.36 1.26e-11 Platelet-derived growth factor BB levels; LUSC trans rs2243480 1.000 rs34637256 chr7:65360131 G/A cg10756647 chr7:56101905 PSPH 0.87 8.39 0.42 1.38e-15 Diabetic kidney disease; LUSC cis rs11677370 0.574 rs10190477 chr2:3862738 A/G cg17052675 chr2:3827356 NA 0.63 9.81 0.47 4.08e-20 Type 2 diabetes; LUSC cis rs12618769 0.597 rs72821956 chr2:99159966 G/T cg10123293 chr2:99228465 UNC50 0.5 8.14 0.41 7.98e-15 Bipolar disorder; LUSC cis rs8060686 0.565 rs4359427 chr16:68202747 C/T cg09835421 chr16:68378352 PRMT7 -0.5 -5.72 -0.3 2.37e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs500891 0.672 rs1418734 chr6:84163888 G/A cg08257003 chr6:84140564 ME1 0.38 9.07 0.44 1.08e-17 Platelet-derived growth factor BB levels; LUSC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg13319975 chr6:146136371 FBXO30 -0.7 -11.11 -0.52 1.26e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs57590327 0.504 rs4856349 chr3:81502928 C/T cg07356753 chr3:81810745 GBE1 0.46 6.15 0.32 2.21e-9 Extraversion; LUSC cis rs9653442 0.863 rs10865035 chr2:100835734 A/G cg22139774 chr2:100720529 AFF3 -0.44 -7.95 -0.4 2.82e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7119038 0.818 rs4936441 chr11:118725660 C/G cg19308663 chr11:118741387 NA -0.36 -6.14 -0.32 2.34e-9 Sjögren's syndrome; LUSC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 12.24 0.56 1.05e-28 Hip circumference adjusted for BMI; LUSC cis rs11608355 0.515 rs2287191 chr12:109931741 C/T cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs12541635 0.967 rs13256474 chr8:107086419 T/C cg10147462 chr8:107024639 NA -0.47 -8.6 -0.43 3.13e-16 Age of smoking initiation; LUSC cis rs10875595 0.836 rs2879202 chr5:140668375 G/T cg24830062 chr5:140700576 TAF7 -0.52 -6.49 -0.33 3.17e-10 Pulmonary function decline; LUSC cis rs10144321 0.903 rs1212911 chr14:100917372 C/T cg14882082 chr14:100845427 WDR25 -0.42 -8.03 -0.4 1.67e-14 Menarche (age at onset); LUSC cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg08754478 chr10:133766260 PPP2R2D -0.63 -8.13 -0.41 8.49e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs62400317 0.762 rs9367210 chr6:44863395 G/A cg18551225 chr6:44695536 NA -0.46 -7.44 -0.38 8.7e-13 Total body bone mineral density; LUSC trans rs853679 0.542 rs9393892 chr6:28081394 A/G cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg09655341 chr17:79618100 PDE6G -0.28 -6.31 -0.33 8.88e-10 Eye color traits; LUSC cis rs9920506 0.536 rs11072768 chr15:78929478 A/C cg04896959 chr15:78267971 NA 0.37 6.59 0.34 1.76e-10 Post bronchodilator FEV1; LUSC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg16325326 chr1:53192061 ZYG11B -0.89 -16.56 -0.67 2.25e-45 Monocyte count; LUSC cis rs10170310 0.872 rs62161711 chr2:139259222 A/G cg03782584 chr2:139258740 SPOPL 0.33 5.89 0.31 9.56e-9 Response to antipsychotic treatment; LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.24 0.37 3.16e-12 Platelet count; LUSC cis rs3770081 1.000 rs56104203 chr2:86336256 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.04 -7.32 -0.37 1.86e-12 Facial emotion recognition (sad faces); LUSC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.69 11.16 0.52 8.78e-25 Prudent dietary pattern; LUSC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg03732007 chr1:2071316 PRKCZ -0.54 -9.94 -0.48 1.46e-20 Height; LUSC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.6 8.63 0.43 2.63e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs17155006 0.746 rs430628 chr7:107746214 T/G cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs5769765 0.955 rs5769761 chr22:50263641 G/T cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.57 -0.34 1.94e-10 Schizophrenia; LUSC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.0 -0.68 3.84e-47 Gut microbiome composition (summer); LUSC cis rs9457247 0.510 rs6456151 chr6:167471851 A/C cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Crohn's disease; LUSC trans rs2243480 0.706 rs34466769 chr7:65453292 A/C cg10756647 chr7:56101905 PSPH 0.84 9.21 0.45 3.82e-18 Diabetic kidney disease; LUSC cis rs55894533 0.597 rs2645408 chr8:11746358 A/G cg21281001 chr8:11725306 CTSB 0.42 5.76 0.3 1.92e-8 Leprosy; LUSC cis rs9896052 0.649 rs6501801 chr17:73447030 A/G cg25649188 chr17:73499917 CASKIN2 -0.38 -5.87 -0.31 1.04e-8 Sight-threatening diabetic retinopathy in type 2 diabetes; LUSC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg08859206 chr1:53392774 SCP2 0.49 8.33 0.41 2.13e-15 Monocyte count; LUSC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg16586182 chr3:47516702 SCAP 0.53 8.62 0.43 2.66e-16 Colorectal cancer; LUSC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg11843238 chr5:131593191 PDLIM4 0.33 5.96 0.31 6.53e-9 Blood metabolite levels; LUSC cis rs4820539 0.966 rs5759600 chr22:23483769 C/A cg21100191 chr22:23484243 RTDR1 0.88 15.05 0.64 1.99e-39 Bone mineral density; LUSC cis rs10788264 0.621 rs9633734 chr10:124057667 T/C cg09507567 chr10:124027408 NA 0.43 7.09 0.36 8e-12 Total body bone mineral density; LUSC cis rs9362426 1.000 rs242271 chr6:88082029 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.38 5.85 0.31 1.15e-8 Depressive episodes in bipolar disorder; LUSC cis rs4285028 0.948 rs35415993 chr3:121669236 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.69 -0.47 9.86e-20 Multiple sclerosis; LUSC cis rs16937 0.597 rs3862949 chr1:205103070 A/T cg00857998 chr1:205179979 DSTYK 0.46 6.56 0.34 1.99e-10 Schizophrenia; LUSC cis rs7904368 0.806 rs1130684 chr10:16859335 C/G cg14835575 chr10:16859367 RSU1 0.81 10.84 0.51 1.14e-23 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg03354898 chr7:1950403 MAD1L1 -0.35 -6.6 -0.34 1.59e-10 Bipolar disorder and schizophrenia; LUSC cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg04415270 chr2:102091202 RFX8 0.56 9.07 0.44 1.02e-17 Chronic rhinosinusitis with nasal polyps; LUSC cis rs7917772 0.582 rs10883753 chr10:104372441 C/T cg22532475 chr10:104410764 TRIM8 -0.25 -6.04 -0.31 4e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs5769707 0.554 rs10854876 chr22:50010570 T/C cg20744362 chr22:50050164 C22orf34 0.38 7.05 0.36 1.03e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg18827107 chr12:86230957 RASSF9 -0.47 -7.06 -0.36 9.99e-12 Major depressive disorder; LUSC cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg15839431 chr19:19639596 YJEFN3 -0.65 -7.16 -0.36 5.25e-12 Bipolar disorder; LUSC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg11062466 chr8:58055876 NA 0.65 8.33 0.41 2.12e-15 Developmental language disorder (linguistic errors); LUSC cis rs9399401 1.000 rs972982 chr6:142666861 A/G cg03128060 chr6:142623767 GPR126 0.31 5.68 0.3 2.97e-8 Chronic obstructive pulmonary disease; LUSC cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.53e-30 Motion sickness; LUSC cis rs238295 0.846 rs6053528 chr20:5582598 G/T cg15842884 chr20:5591925 RP5-1022P6.2 -0.44 -5.96 -0.31 6.53e-9 Occipital cortical area (total cortical area interaction); LUSC cis rs6882046 0.513 rs647983 chr5:88048071 T/C cg22951263 chr5:87985283 NA -0.47 -7.72 -0.39 1.39e-13 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; LUSC trans rs7937682 0.924 rs10891283 chr11:111527672 A/G cg18187862 chr3:45730750 SACM1L 0.55 7.09 0.36 8.01e-12 Primary sclerosing cholangitis; LUSC cis rs6546550 0.901 rs6739780 chr2:70138111 G/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs7927592 0.871 rs17603185 chr11:68376241 C/T cg16797656 chr11:68205561 LRP5 0.38 6.19 0.32 1.77e-9 Total body bone mineral density; LUSC cis rs9309473 0.607 rs12478346 chr2:73584360 C/T cg20560298 chr2:73613845 ALMS1 -0.61 -8.96 -0.44 2.37e-17 Metabolite levels; LUSC cis rs36093844 0.698 rs79435802 chr11:85585206 T/C cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg06637938 chr14:75390232 RPS6KL1 -0.53 -8.59 -0.43 3.48e-16 Height; LUSC trans rs9329221 0.619 rs591346 chr8:9818065 C/T cg21775007 chr8:11205619 TDH -0.51 -7.45 -0.38 7.94e-13 Neuroticism; LUSC cis rs10419226 0.540 rs6510995 chr19:18770776 G/A cg22001208 chr19:18782374 NA -0.38 -6.39 -0.33 5.73e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg17892150 chr10:133769511 PPP2R2D -0.67 -9.3 -0.45 1.91e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg25072359 chr17:41440525 NA 0.69 9.65 0.47 1.36e-19 Menopause (age at onset); LUSC cis rs4595586 0.545 rs7976609 chr12:39394317 T/C cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs983392 0.709 rs56273223 chr11:59984676 A/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.92 -0.31 8.12e-9 Alzheimer's disease (late onset); LUSC cis rs3931020 0.671 rs1327088 chr1:75255491 A/G cg26855724 chr1:75198818 TYW3;CRYZ 0.44 6.87 0.35 3.17e-11 Resistin levels; LUSC cis rs7917772 0.582 rs10786696 chr10:104378134 A/G cg05855489 chr10:104503620 C10orf26 -0.48 -7.35 -0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7605827 0.930 rs1015836 chr2:15665719 A/G cg12784241 chr6:158402508 SYNJ2 0.36 6.08 0.32 3.3e-9 Educational attainment (years of education); LUSC cis rs887829 0.570 rs10168333 chr2:234596988 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -6.28 -0.33 1.04e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs3087591 0.922 rs2905801 chr17:29524974 C/T cg24425628 chr17:29625626 OMG;NF1 0.6 8.55 0.42 4.36e-16 Hip circumference; LUSC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg03684893 chr10:554711 DIP2C 0.35 6.03 0.31 4.24e-9 Psychosis in Alzheimer's disease; LUSC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg07587117 chr16:2239488 CASKIN1 0.33 6.44 0.33 4.27e-10 Height; LUSC trans rs10511400 0.618 rs923726 chr3:119917879 T/C cg02809009 chr19:50354510 PTOV1 -0.72 -6.43 -0.33 4.52e-10 Economic and political preferences (feminism/equality); LUSC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg00343986 chr7:65444356 GUSB 0.44 6.8 0.35 4.95e-11 Aortic root size; LUSC cis rs4343996 0.558 rs10235815 chr7:3413867 T/G cg21248987 chr7:3385318 SDK1 0.36 6.19 0.32 1.8e-9 Motion sickness; LUSC cis rs422249 0.634 rs174616 chr11:61629122 C/T cg06860612 chr11:61641270 FADS3 0.28 5.89 0.31 9.66e-9 Trans fatty acid levels; LUSC cis rs4499344 0.556 rs438268 chr19:33109904 A/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.9 12.49 0.56 1.22e-29 Mean platelet volume; LUSC cis rs317689 0.718 rs160827 chr12:69770147 G/A cg11871910 chr12:69753446 YEATS4 0.6 8.04 0.4 1.6e-14 Response to diuretic therapy; LUSC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg00339695 chr16:24857497 SLC5A11 -0.36 -5.98 -0.31 5.69e-9 Intelligence (multi-trait analysis); LUSC cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg23583168 chr7:148888333 NA -0.85 -14.94 -0.63 5.32e-39 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9463078 0.764 rs6458415 chr6:44881592 G/C cg25276700 chr6:44698697 NA -0.28 -5.74 -0.3 2.08e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs936229 0.861 rs11634474 chr15:75116184 C/G cg10253484 chr15:75165896 SCAMP2 -0.49 -6.48 -0.33 3.26e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs1670533 1.000 rs633556 chr4:1092405 A/G cg02018176 chr4:1364513 KIAA1530 0.44 6.2 0.32 1.66e-9 Recombination rate (females); LUSC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg24110177 chr3:50126178 RBM5 -0.64 -11.08 -0.52 1.67e-24 Body mass index; LUSC cis rs4077515 0.806 rs3812564 chr9:139271190 A/G cg14019695 chr9:139328340 INPP5E 0.43 8.25 0.41 3.6e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2070488 0.775 rs2051214 chr3:38560303 C/A cg24069376 chr3:38537580 EXOG -0.4 -7.65 -0.39 2.16e-13 Electrocardiographic conduction measures; LUSC cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg18252515 chr7:66147081 NA 1.2 13.92 0.61 4.64e-35 Diabetic kidney disease; LUSC cis rs3849570 0.555 rs4481177 chr3:81996817 A/T cg07356753 chr3:81810745 GBE1 0.42 6.09 0.32 3.1e-9 Waist circumference;Body mass index; LUSC trans rs35110281 0.641 rs4818858 chr21:45083097 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.64 -10.89 -0.51 7.99e-24 Mean corpuscular volume; LUSC cis rs4629710 0.538 rs11754401 chr6:131582197 G/A cg12606694 chr6:131520996 AKAP7 0.63 9.65 0.47 1.36e-19 Multiple myeloma (IgH translocation); LUSC cis rs11122272 0.735 rs2250749 chr1:231485763 C/G cg06096015 chr1:231504339 EGLN1 0.54 9.38 0.46 1.02e-18 Hemoglobin concentration; LUSC cis rs7247513 0.639 rs12984441 chr19:12760287 A/C cg01871581 chr19:12707946 ZNF490 -0.57 -8.85 -0.44 5.04e-17 Bipolar disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg08467185 chr19:12917312 RNASEH2A 0.74 6.19 0.32 1.79e-9 Cognitive performance; LUSC cis rs9549260 0.755 rs9532571 chr13:41218670 C/T cg21288729 chr13:41239152 FOXO1 0.61 9.47 0.46 5.35e-19 Red blood cell count; LUSC cis rs6554196 0.508 rs999021 chr4:55524533 C/G cg18836493 chr4:55524333 KIT -0.43 -7.43 -0.38 9.31e-13 Monocyte count; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg02107564 chr22:41488750 EP300 0.43 6.55 0.34 2.19e-10 Triglycerides; LUSC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg25036284 chr2:26402008 FAM59B 0.69 9.19 0.45 4.15e-18 Gut microbiome composition (summer); LUSC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg17971929 chr21:40555470 PSMG1 -0.47 -7.13 -0.36 6.08e-12 Menarche (age at onset); LUSC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg14895029 chr7:2775587 GNA12 -0.42 -6.48 -0.33 3.37e-10 Height; LUSC trans rs3749237 0.964 rs11714957 chr3:49776178 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.52 7.09 0.36 8.23e-12 Resting heart rate; LUSC cis rs4400599 0.549 rs12044616 chr1:154189417 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.15 -0.32 2.24e-9 Platelet distribution width; LUSC cis rs10256972 0.630 rs10282584 chr7:1081442 C/T cg25428297 chr7:1022841 CYP2W1 0.28 6.01 0.31 4.82e-9 Longevity;Endometriosis; LUSC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg25272121 chr1:152190972 HRNR -0.39 -6.76 -0.35 6.05e-11 Inflammatory skin disease; LUSC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg12311346 chr5:56204834 C5orf35 -0.87 -12.47 -0.56 1.47e-29 Initial pursuit acceleration; LUSC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg04727924 chr7:799746 HEATR2 -0.55 -6.67 -0.34 1.07e-10 Cerebrospinal P-tau181p levels; LUSC cis rs9399401 0.961 rs2039986 chr6:142655238 G/A cg03128060 chr6:142623767 GPR126 0.31 5.68 0.3 3e-8 Chronic obstructive pulmonary disease; LUSC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg04267008 chr7:1944627 MAD1L1 -0.59 -8.81 -0.43 6.75e-17 Schizophrenia; LUSC cis rs11105298 0.891 rs10858899 chr12:89923811 G/C cg00757033 chr12:89920650 WDR51B 0.59 10.34 0.49 6.1e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs34421088 0.560 rs2248316 chr8:11397073 A/C cg27411982 chr8:10470053 RP1L1 -0.38 -5.9 -0.31 8.95e-9 Neuroticism; LUSC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs3784262 1.000 rs7495968 chr15:58244103 C/G cg12031962 chr15:58353849 ALDH1A2 0.33 6.19 0.32 1.8e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg01802117 chr1:53393560 SCP2 -0.39 -6.37 -0.33 6.33e-10 Monocyte count; LUSC trans rs61931739 0.534 rs1608912 chr12:34008574 C/T cg26384229 chr12:38710491 ALG10B 0.58 9.51 0.46 4.02e-19 Morning vs. evening chronotype; LUSC cis rs7937890 0.904 rs7484197 chr11:14283654 C/T cg19336497 chr11:14380999 RRAS2 -0.32 -5.68 -0.3 2.96e-8 Mitochondrial DNA levels; LUSC cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 8.77 0.43 9.43e-17 Axial length; LUSC cis rs68170813 0.559 rs74925723 chr7:106954536 G/C cg02696742 chr7:106810147 HBP1 -0.63 -9.54 -0.46 3.16e-19 Coronary artery disease; LUSC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg06640241 chr16:89574553 SPG7 0.71 11.32 0.53 2.24e-25 Multiple myeloma (IgH translocation); LUSC cis rs6845621 0.700 rs6839469 chr4:18916269 A/G cg12196642 chr4:18937545 NA -0.34 -6.29 -0.33 9.99e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs6840360 0.571 rs72730104 chr4:152543857 A/G cg22705602 chr4:152727874 NA -0.33 -6.63 -0.34 1.36e-10 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg21770322 chr7:97807741 LMTK2 0.41 7.21 0.37 3.79e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs1372520 0.935 rs1442152 chr4:90775649 C/A cg15133208 chr4:90757351 SNCA -0.53 -8.19 -0.41 5.6e-15 Neuroticism; LUSC cis rs17014483 1.000 rs2860528 chr4:89655632 G/A cg01026744 chr4:89619053 NAP1L5;HERC3 0.68 5.76 0.3 1.93e-8 Post bronchodilator FEV1/FVC ratio; LUSC cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.74 0.43 1.13e-16 Menarche (age at onset); LUSC cis rs11098499 0.954 rs2389802 chr4:120325732 C/A cg24375607 chr4:120327624 NA 0.78 11.57 0.53 2.96e-26 Corneal astigmatism; LUSC cis rs3857536 0.813 rs9360190 chr6:66942302 T/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs7216064 1.000 rs12451707 chr17:65871598 G/A cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs56283067 0.887 rs12215095 chr6:44756910 T/C cg20913747 chr6:44695427 NA -0.43 -6.69 -0.34 9.17e-11 Total body bone mineral density; LUSC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg20135002 chr11:47629003 NA -0.52 -8.15 -0.41 7.6e-15 Subjective well-being; LUSC cis rs9943753 0.508 rs7138357 chr12:109832303 A/G cg19025524 chr12:109796872 NA -0.38 -6.98 -0.36 1.59e-11 HDL cholesterol; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01858923 chr14:65569399 MAX -0.41 -6.0 -0.31 5.09e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg06238570 chr21:40685208 BRWD1 0.48 7.49 0.38 6.36e-13 Cognitive function; LUSC cis rs2479724 1.000 rs2479724 chr6:41890982 T/C cg17623882 chr6:41773611 USP49 -0.62 -10.15 -0.49 2.91e-21 Menarche (age at onset); LUSC cis rs2486288 0.656 rs6493145 chr15:45573862 G/T cg26924012 chr15:45694286 SPATA5L1 -0.74 -10.99 -0.52 3.32e-24 Glomerular filtration rate; LUSC cis rs2842992 0.714 rs2475564 chr6:160123673 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.55 6.99 0.36 1.51e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg13395646 chr4:1353034 KIAA1530 -0.57 -8.73 -0.43 1.2e-16 Obesity-related traits; LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg25767906 chr1:53392781 SCP2 -0.51 -9.21 -0.45 3.7e-18 Monocyte count; LUSC cis rs7107174 1.000 rs10899477 chr11:78052104 A/T cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg00012203 chr2:219082015 ARPC2 -0.56 -8.98 -0.44 2.07e-17 Ulcerative colitis; LUSC cis rs9300255 0.544 rs1716157 chr12:123670473 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.13 -0.32 2.47e-9 Neutrophil percentage of white cells; LUSC cis rs8072100 0.512 rs9303533 chr17:45386540 A/G cg25173405 chr17:45401733 C17orf57 -0.4 -6.38 -0.33 5.8e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9611565 0.504 rs5758452 chr22:42144927 G/A cg03806693 chr22:41940476 POLR3H 0.85 12.22 0.56 1.25e-28 Vitiligo; LUSC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg24531977 chr5:56204891 C5orf35 -0.72 -10.75 -0.51 2.41e-23 Coronary artery disease; LUSC trans rs750134 0.901 rs12423733 chr12:109117989 C/T cg23338993 chr2:234600423 UGT1A10;UGT1A6;UGT1A9;UGT1A7;UGT1A8 0.48 6.05 0.31 3.94e-9 Low high density lipoprotein cholesterol levels; LUSC cis rs1801251 1.000 rs7606090 chr2:233606740 T/C cg08000102 chr2:233561755 GIGYF2 0.67 11.12 0.52 1.16e-24 Coronary artery disease; LUSC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.87 -0.31 1.06e-8 Platelet count; LUSC trans rs564343 0.583 rs571374 chr11:65817592 C/T cg26701943 chr11:108369231 KDELC2 -0.44 -6.12 -0.32 2.6e-9 Obesity (early onset extreme); LUSC cis rs4654899 0.643 rs589755 chr1:21099846 A/G cg01072550 chr1:21505969 NA -0.45 -6.78 -0.35 5.43e-11 Superior frontal gyrus grey matter volume; LUSC cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg12935359 chr14:103987150 CKB -0.61 -9.88 -0.48 2.35e-20 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.603 rs2998427 chr1:231528112 A/G cg06096015 chr1:231504339 EGLN1 0.57 10.12 0.48 3.69e-21 Hemoglobin concentration; LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18099408 chr3:52552593 STAB1 -0.41 -6.96 -0.36 1.84e-11 Bipolar disorder; LUSC cis rs7615316 0.779 rs4441672 chr3:142149212 C/T cg16271453 chr3:142027066 XRN1 -0.42 -7.15 -0.36 5.43e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs77106637 0.932 rs3814730 chr11:72555553 G/A cg03878208 chr11:72483293 STARD10 0.59 7.71 0.39 1.45e-13 Type 2 diabetes; LUSC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg18904891 chr8:8559673 CLDN23 0.6 8.32 0.41 2.27e-15 Obesity-related traits; LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.41 0.42 1.2e-15 Prudent dietary pattern; LUSC cis rs7577696 0.711 rs385076 chr2:32489851 T/C cg02381751 chr2:32503542 YIPF4 0.42 6.0 0.31 5.1e-9 Inflammatory biomarkers; LUSC trans rs3942852 0.703 rs11039513 chr11:48107204 C/T cg15704280 chr7:45808275 SEPT13 0.62 7.69 0.39 1.62e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs35883536 0.566 rs12566440 chr1:101095202 A/G cg06223162 chr1:101003688 GPR88 0.36 6.39 0.33 5.7e-10 Monocyte count; LUSC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg06221963 chr1:154839813 KCNN3 0.46 9.08 0.44 9.72e-18 Prostate cancer; LUSC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11890956 chr21:40555474 PSMG1 -0.74 -11.22 -0.52 5.44e-25 Menarche (age at onset); LUSC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg08684580 chr7:98029266 BAIAP2L1 0.45 8.35 0.42 1.83e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs4664308 0.618 rs35771982 chr2:160885418 G/C cg03641300 chr2:160917029 PLA2R1 -0.47 -7.74 -0.39 1.15e-13 Idiopathic membranous nephropathy; LUSC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.01 0.31 4.88e-9 Menopause (age at onset); LUSC trans rs10090774 0.965 rs11780104 chr8:142002107 C/T cg16477744 chr7:157367142 PTPRN2;MIR153-2 0.28 6.04 0.31 4.13e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs4478037 1.000 rs61433006 chr3:33162363 T/A cg19404215 chr3:33155277 CRTAP 0.96 10.11 0.48 4.01e-21 Major depressive disorder; LUSC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg02951883 chr7:2050386 MAD1L1 -0.51 -9.06 -0.44 1.11e-17 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg11764359 chr7:65958608 NA 0.63 9.44 0.46 6.47e-19 Aortic root size; LUSC cis rs4253772 0.872 rs78864133 chr22:46638486 C/T cg24881330 chr22:46731750 TRMU 0.63 5.78 0.3 1.72e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9467773 1.000 rs9461259 chr6:26504835 C/A cg09904177 chr6:26538194 HMGN4 0.73 13.27 0.59 1.45e-32 Intelligence (multi-trait analysis); LUSC cis rs1864400 0.690 rs2565200 chr10:43622933 A/G cg15436174 chr10:43711423 RASGEF1A -0.41 -6.94 -0.35 2.08e-11 Hirschsprung disease; LUSC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.42 0.42 1.14e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs8114671 0.562 rs2425005 chr20:33407715 C/G cg25333225 chr19:40791658 AKT2 -0.55 -6.76 -0.35 6.26e-11 Height; LUSC cis rs12286929 0.780 rs2187986 chr11:115001410 C/T cg04055981 chr11:115044050 NA 0.33 5.73 0.3 2.19e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2072499 0.778 rs2842868 chr1:156196407 A/C cg25208724 chr1:156163844 SLC25A44 0.98 16.07 0.66 1.85e-43 Testicular germ cell tumor; LUSC cis rs13089785 0.965 rs12493045 chr3:123620718 C/A cg01860459 chr3:123419554 MYLK 0.35 5.95 0.31 6.83e-9 Intelligence (multi-trait analysis); LUSC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg18240062 chr17:79603768 NPLOC4 0.69 12.86 0.58 4.98e-31 Eye color traits; LUSC cis rs926938 0.527 rs360684 chr1:115499001 A/G cg12756093 chr1:115239321 AMPD1 0.43 6.51 0.34 2.69e-10 Autism; LUSC cis rs56399783 0.901 rs73049380 chr7:2832845 C/T cg19731401 chr7:2775893 GNA12 0.69 9.57 0.46 2.53e-19 Childhood ear infection; LUSC cis rs12190007 0.517 rs3006183 chr6:169808263 T/C cg15038512 chr6:170123185 PHF10 -0.38 -6.14 -0.32 2.34e-9 Obesity-related traits; LUSC cis rs11626933 1.000 rs45463097 chr14:90744188 G/A cg14092571 chr14:90743983 NA -0.9 -18.67 -0.71 8.83e-54 Gut microbiota (bacterial taxa); LUSC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg11843238 chr5:131593191 PDLIM4 0.46 7.78 0.39 9.34e-14 Acylcarnitine levels; LUSC trans rs11722228 0.521 rs12501336 chr4:10137351 G/A cg26043149 chr18:55253948 FECH 1.01 16.73 0.68 4.65e-46 Gout;Urate levels;Serum uric acid levels; LUSC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg03676636 chr4:99064102 C4orf37 0.34 7.56 0.38 3.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs864537 0.618 rs2988277 chr1:167431352 A/G cg09179987 chr1:167433047 CD247 -0.36 -5.94 -0.31 7.26e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs9796 0.558 rs11855102 chr15:41513257 T/C cg18705301 chr15:41695430 NDUFAF1 -0.5 -8.85 -0.44 5.33e-17 Menopause (age at onset); LUSC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg06637938 chr14:75390232 RPS6KL1 0.53 8.62 0.43 2.76e-16 Height; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg07677032 chr17:61819896 STRADA 0.49 8.18 0.41 6.14e-15 Prudent dietary pattern; LUSC cis rs7020830 0.823 rs7019699 chr9:37125081 C/A cg14294708 chr9:37120828 ZCCHC7 1.12 26.67 0.82 9.47e-85 Schizophrenia; LUSC cis rs983392 0.709 rs4939320 chr11:59981801 T/C cg24026212 chr11:59952134 MS4A6A -0.35 -6.07 -0.32 3.51e-9 Alzheimer's disease (late onset); LUSC cis rs477692 0.905 rs7905466 chr10:131438937 A/T cg11019008 chr10:131425282 MGMT -0.41 -6.26 -0.32 1.16e-9 Response to temozolomide; LUSC cis rs12579753 1.000 rs12579753 chr12:82219376 C/T cg21231944 chr12:82153410 PPFIA2 -0.4 -5.93 -0.31 7.71e-9 Resting heart rate; LUSC trans rs1997103 0.911 rs11238361 chr7:55395981 A/G cg20935933 chr6:143382018 AIG1 0.5 7.32 0.37 1.92e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs2996428 0.667 rs11578581 chr1:3770642 G/A cg22529645 chr1:3704559 LRRC47 0.35 6.12 0.32 2.63e-9 Red cell distribution width; LUSC cis rs17102884 0.506 rs4899540 chr14:75403408 G/A cg06637938 chr14:75390232 RPS6KL1 -0.44 -6.55 -0.34 2.2e-10 Neuroticism; LUSC trans rs629535 0.862 rs662725 chr8:70029616 C/T cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg20243544 chr17:37824526 PNMT 0.53 7.78 0.39 9.15e-14 Asthma; LUSC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg22823121 chr1:150693482 HORMAD1 0.59 9.21 0.45 3.57e-18 Tonsillectomy; LUSC cis rs6736093 0.901 rs34875611 chr2:112763025 G/A cg12686935 chr2:112915763 FBLN7 -0.37 -5.96 -0.31 6.41e-9 Coronary artery disease; LUSC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg08270630 chr22:50330655 NA -0.44 -6.61 -0.34 1.48e-10 Schizophrenia; LUSC cis rs3820928 0.874 rs2177594 chr2:227836239 C/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.52 -0.38 5.01e-13 Pulmonary function; LUSC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.6e-16 Lung cancer; LUSC cis rs3020736 0.500 rs2413672 chr22:42513261 C/T cg05082376 chr22:42548792 NA 0.43 6.55 0.34 2.14e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs12464483 0.524 rs4952172 chr2:30888286 A/G cg17749961 chr2:30669863 LCLAT1 -0.62 -7.67 -0.39 1.96e-13 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.05 0.36 1.03e-11 Bipolar disorder; LUSC cis rs952623 0.649 rs6974522 chr7:39073372 G/C cg15212455 chr7:39170539 POU6F2 0.36 5.86 0.31 1.09e-8 Intelligence (multi-trait analysis); LUSC cis rs9910055 0.639 rs227583 chr17:42231698 C/G cg13607699 chr17:42295918 UBTF 0.49 7.63 0.39 2.41e-13 Total body bone mineral density; LUSC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg25282410 chr6:160211355 TCP1;MRPL18 -1.18 -21.49 -0.76 6.25e-65 Age-related macular degeneration (geographic atrophy); LUSC cis rs868036 0.718 rs922494 chr15:68120644 T/C cg24579218 chr15:68104479 NA -0.37 -6.48 -0.33 3.25e-10 Restless legs syndrome; LUSC cis rs9399401 0.845 rs263186 chr6:142861491 A/G cg03128060 chr6:142623767 GPR126 0.31 5.86 0.31 1.13e-8 Chronic obstructive pulmonary disease; LUSC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg07395648 chr5:131743802 NA -0.38 -5.76 -0.3 1.88e-8 Breast cancer; LUSC cis rs11018904 0.906 rs10501713 chr11:89953013 G/A cg26028595 chr11:89956573 CHORDC1 -0.52 -6.11 -0.32 2.84e-9 Intelligence (multi-trait analysis); LUSC cis rs11785400 0.701 rs9721143 chr8:143727511 A/T cg10596483 chr8:143751796 JRK 0.52 7.57 0.38 3.79e-13 Schizophrenia; LUSC cis rs9303401 0.659 rs7224276 chr17:56897827 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.71 0.6 3.09e-34 Cognitive test performance; LUSC trans rs2262909 1.000 rs2078089 chr19:22209753 A/T cg17074339 chr11:11642133 GALNTL4 -0.41 -6.2 -0.32 1.68e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs36093844 0.615 rs77258124 chr11:85578081 G/A cg25872744 chr11:85566296 CCDC83 -0.45 -5.88 -0.31 9.88e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg24642844 chr7:1081250 C7orf50 -0.7 -10.18 -0.49 2.21e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6541297 0.941 rs6690424 chr1:230278892 C/T cg05784532 chr1:230284198 GALNT2 0.49 7.39 0.38 1.16e-12 Coronary artery disease; LUSC cis rs10191773 0.535 rs56048537 chr2:113078467 G/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.63 -7.82 -0.39 6.77e-14 Yeast infection; LUSC cis rs6121246 0.567 rs7266471 chr20:30220599 T/A cg13852791 chr20:30311386 BCL2L1 0.79 8.89 0.44 3.84e-17 Mean corpuscular hemoglobin; LUSC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg12463550 chr7:65579703 CRCP -0.52 -7.44 -0.38 8.51e-13 Aortic root size; LUSC cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg00012203 chr2:219082015 ARPC2 -0.75 -12.9 -0.58 3.64e-31 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs12530845 0.673 rs4073627 chr7:135312572 A/G cg23117316 chr7:135346802 PL-5283 0.62 9.77 0.47 5.55e-20 Red blood cell traits; LUSC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7827545 1.000 rs1372662 chr8:135567046 C/G cg17885191 chr8:135476712 NA 0.58 8.9 0.44 3.71e-17 Hypertension (SNP x SNP interaction); LUSC cis rs1865721 0.682 rs3745082 chr18:73142734 G/T cg26385618 chr18:73139727 C18orf62 -0.47 -8.83 -0.44 5.92e-17 Intelligence; LUSC cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg17366294 chr4:99064904 C4orf37 0.5 8.71 0.43 1.48e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs317689 0.513 rs317659 chr12:69686132 T/A cg14784868 chr12:69753453 YEATS4 0.54 8.07 0.4 1.27e-14 Response to diuretic therapy; LUSC cis rs8072100 0.754 rs8081717 chr17:45653921 T/A cg08085267 chr17:45401833 C17orf57 0.59 9.85 0.47 2.96e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7112925 0.738 rs11227673 chr11:66832528 C/T cg24851651 chr11:66362959 CCS -0.36 -6.05 -0.31 3.83e-9 Height; LUSC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg19592336 chr6:28129416 ZNF389 0.5 6.6 0.34 1.61e-10 Parkinson's disease; LUSC trans rs140364877 1 rs140364877 chr7:1885178 C/T cg11244813 chr1:145039882 PDE4DIP 0.38 6.05 0.31 3.88e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs6964587 1.000 rs2075881 chr7:91734552 T/C cg01689657 chr7:91764605 CYP51A1 0.31 5.73 0.3 2.22e-8 Breast cancer; LUSC cis rs10992471 0.603 rs12341817 chr9:95252152 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.77 -0.39 9.98e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs12651329 1.000 rs12651329 chr4:36079594 A/G cg11850622 chr4:159593397 ETFDH;C4orf46 -0.39 -6.04 -0.31 4.05e-9 Amyotrophic lateral sclerosis (age of onset); LUSC cis rs12928939 0.911 rs11645704 chr16:71826611 G/T cg03805757 chr16:71968109 PKD1L3 -0.46 -6.65 -0.34 1.23e-10 Post bronchodilator FEV1; LUSC cis rs7605827 0.930 rs4668918 chr2:15661992 A/T cg19274914 chr2:15703543 NA 0.44 8.22 0.41 4.55e-15 Educational attainment (years of education); LUSC cis rs7523050 0.643 rs17563938 chr1:109401654 C/T cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs7208859 0.673 rs9899525 chr17:29120296 T/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg19592336 chr6:28129416 ZNF389 0.51 6.58 0.34 1.8e-10 Depression; LUSC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg01181863 chr3:195395398 SDHAP2 -0.54 -7.48 -0.38 6.51e-13 Pancreatic cancer; LUSC cis rs709400 0.663 rs62007684 chr14:103894223 T/C cg12935359 chr14:103987150 CKB -0.57 -8.68 -0.43 1.81e-16 Body mass index; LUSC cis rs4557202 0.509 rs12690576 chr3:160647912 G/A cg03342759 chr3:160939853 NMD3 -0.44 -6.12 -0.32 2.57e-9 Menarche (age at onset); LUSC cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg24642439 chr20:33292090 TP53INP2 -0.51 -7.62 -0.38 2.73e-13 Glomerular filtration rate (creatinine); LUSC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg01879757 chr17:41196368 BRCA1 -0.45 -7.33 -0.37 1.7e-12 Menopause (age at onset); LUSC cis rs250677 0.687 rs171636 chr5:148434545 G/A cg12140854 chr5:148520817 ABLIM3 -0.4 -5.86 -0.31 1.1e-8 Breast cancer; LUSC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg20203395 chr5:56204925 C5orf35 -0.74 -10.01 -0.48 8.49e-21 Initial pursuit acceleration; LUSC cis rs2637266 0.655 rs846628 chr10:78538392 G/A cg18941641 chr10:78392320 NA 0.39 7.06 0.36 9.84e-12 Pulmonary function; LUSC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4964805 0.913 rs7134701 chr12:104202691 C/T cg02344784 chr12:104178138 NT5DC3 0.44 7.07 0.36 9.28e-12 Attention deficit hyperactivity disorder; LUSC cis rs8031584 0.672 rs17227989 chr15:31293774 T/C cg14829155 chr15:31115871 NA -0.55 -6.72 -0.34 8.01e-11 Huntington's disease progression; LUSC cis rs7605827 0.836 rs9287659 chr2:15595755 C/T cg19274914 chr2:15703543 NA 0.46 8.76 0.43 1e-16 Educational attainment (years of education); LUSC cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 9.55 0.46 2.9e-19 Mean platelet volume; LUSC cis rs4812048 0.649 rs6070702 chr20:57621562 G/C cg14073986 chr20:57617431 SLMO2 0.88 9.5 0.46 4.16e-19 Mean platelet volume; LUSC cis rs1691799 0.867 rs1168342 chr12:66758734 A/T cg16791601 chr12:66731901 HELB -0.71 -12.37 -0.56 3.47e-29 White blood cell count (basophil); LUSC cis rs9467711 0.651 rs16891334 chr6:26124303 T/C cg08501292 chr6:25962987 TRIM38 0.65 5.86 0.31 1.12e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs7980799 0.682 rs1580396 chr12:33615841 C/A cg13010199 chr12:38710504 ALG10B -0.43 -6.35 -0.33 7.23e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs752010 0.695 rs10890155 chr1:42107843 C/T cg06885757 chr1:42089581 HIVEP3 0.44 8.51 0.42 6.01e-16 Lupus nephritis in systemic lupus erythematosus; LUSC trans rs7916697 0.593 rs7912895 chr10:70021498 A/G cg04882175 chr6:131122610 NA -0.48 -6.46 -0.33 3.68e-10 Optic disc area; LUSC cis rs7659604 0.540 rs10004284 chr4:122699222 A/T cg19748678 chr4:122722346 EXOSC9 -0.49 -7.32 -0.37 1.82e-12 Type 2 diabetes; LUSC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 6.23 0.32 1.44e-9 Personality dimensions; LUSC cis rs1419980 0.673 rs4883421 chr12:7774028 A/G cg25828445 chr12:7781288 NA 0.58 6.09 0.32 3.03e-9 HDL cholesterol levels; LUSC trans rs6951245 1.000 rs11763835 chr7:1094513 A/G cg13565492 chr6:43139072 SRF -0.61 -6.4 -0.33 5.21e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.89e-10 Life satisfaction; LUSC cis rs7917772 0.560 rs4919664 chr10:104363408 A/C cg22532475 chr10:104410764 TRIM8 -0.25 -5.99 -0.31 5.4e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs79387448 0.655 rs3771167 chr2:102986188 A/G cg09003973 chr2:102972529 NA 1.22 13.03 0.58 1.2e-31 Gut microbiota (bacterial taxa); LUSC trans rs3733585 0.699 rs7699609 chr4:9961059 A/G cg26043149 chr18:55253948 FECH -0.46 -7.06 -0.36 9.71e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg15242686 chr22:24348715 GSTTP1 0.48 7.59 0.38 3.24e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1538970 0.924 rs2088100 chr1:45877575 C/T cg05343316 chr1:45956843 TESK2 0.62 8.63 0.43 2.49e-16 Platelet count; LUSC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC trans rs853679 0.546 rs71537572 chr6:27970715 T/C cg01620082 chr3:125678407 NA -0.8 -7.32 -0.37 1.86e-12 Depression; LUSC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg11871910 chr12:69753446 YEATS4 0.91 16.98 0.68 4.65e-47 Cerebrospinal fluid biomarker levels; LUSC trans rs12692738 0.526 rs355860 chr2:165629911 T/G cg26993132 chr16:89239499 CDH15 0.31 6.03 0.31 4.36e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2835872 0.965 rs2835849 chr21:39011524 T/C cg20424643 chr21:39039972 KCNJ6 0.39 6.05 0.31 3.87e-9 Electroencephalographic traits in alcoholism; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.7 -0.3 2.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2885056 0.783 rs12459941 chr19:10666112 A/G cg06392426 chr19:10676186 KRI1 -0.48 -5.76 -0.3 1.89e-8 Red cell distribution width; LUSC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg11764359 chr7:65958608 NA 0.62 9.22 0.45 3.55e-18 Aortic root size; LUSC trans rs11723530 0.507 rs4692584 chr4:170814421 C/T cg14385325 chr17:74564821 ST6GALNAC2 -0.32 -6.28 -0.32 1.03e-9 Myopia (pathological); LUSC cis rs9341808 0.905 rs9343977 chr6:80967001 C/T cg08355045 chr6:80787529 NA 0.52 9.16 0.45 5.36e-18 Sitting height ratio; LUSC cis rs11190604 1.000 rs7079756 chr10:102302105 G/A cg16342193 chr10:102329863 NA -0.32 -5.88 -0.31 1.02e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2219968 1.000 rs34130020 chr8:78962583 T/C cg00738934 chr8:78996279 NA 0.34 6.18 0.32 1.89e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg24531977 chr5:56204891 C5orf35 -0.56 -8.27 -0.41 3.31e-15 Breast cancer;Breast cancer (early onset); LUSC cis rs2073300 1.000 rs6048813 chr20:23448221 G/A cg09953122 chr20:23471693 CST8 -0.72 -6.61 -0.34 1.54e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg22535103 chr8:58192502 C8orf71 -0.84 -10.03 -0.48 7.15e-21 Developmental language disorder (linguistic errors); LUSC trans rs853679 1.000 rs853679 chr6:28296863 C/A cg06606381 chr12:133084897 FBRSL1 -0.58 -6.44 -0.33 4.25e-10 Depression; LUSC cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg09184832 chr6:79620586 NA -0.44 -7.0 -0.36 1.39e-11 Intelligence (multi-trait analysis); LUSC cis rs10875746 0.859 rs4760680 chr12:48466697 G/T cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs3790645 0.645 rs3790644 chr1:26884676 G/A cg17456097 chr1:26900765 RPS6KA1 0.52 7.05 0.36 1.03e-11 Glucose homeostasis traits; LUSC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg04518342 chr5:131593106 PDLIM4 0.45 8.25 0.41 3.63e-15 Breast cancer; LUSC cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg12310025 chr6:25882481 NA -0.5 -9.06 -0.44 1.09e-17 Blood metabolite levels; LUSC cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg23788917 chr6:8435910 SLC35B3 0.5 7.35 0.37 1.49e-12 Motion sickness; LUSC cis rs9300255 0.596 rs10734900 chr12:123743445 G/A cg00376283 chr12:123451042 ABCB9 0.7 9.84 0.47 3.03e-20 Neutrophil percentage of white cells; LUSC cis rs7845219 0.539 rs13271644 chr8:95853948 A/G cg23172400 chr8:95962367 TP53INP1 -0.29 -5.91 -0.31 8.57e-9 Type 2 diabetes; LUSC cis rs7927592 0.913 rs11228292 chr11:68379772 C/T cg20283391 chr11:68216788 NA -0.6 -8.45 -0.42 9.21e-16 Total body bone mineral density; LUSC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg23630131 chr7:65973040 NA 0.21 5.66 0.3 3.26e-8 Aortic root size; LUSC cis rs11098499 0.954 rs71629403 chr4:120372567 C/T cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg22823121 chr1:150693482 HORMAD1 0.51 7.46 0.38 7.39e-13 Melanoma; LUSC cis rs7202877 0.610 rs11149814 chr16:75332981 T/C cg04384234 chr16:75411784 CFDP1 -0.63 -8.83 -0.44 6.02e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9303401 0.659 rs714959 chr17:56628601 A/G cg25039879 chr17:56429692 SUPT4H1 0.66 9.06 0.44 1.11e-17 Cognitive test performance; LUSC cis rs911555 0.755 rs8014800 chr14:103946302 T/C cg12935359 chr14:103987150 CKB 0.66 10.79 0.51 1.68e-23 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12881726 chr7:30544409 GGCT -0.41 -6.06 -0.31 3.61e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs60871478 1.000 rs9195 chr7:825786 C/T cg04727924 chr7:799746 HEATR2 0.55 7.13 0.36 6.15e-12 Cerebrospinal P-tau181p levels; LUSC trans rs9329221 0.506 rs6993610 chr8:10330994 C/G cg15556689 chr8:8085844 FLJ10661 -0.52 -7.42 -0.38 1e-12 Neuroticism; LUSC cis rs738322 0.574 rs738323 chr22:38569527 C/T cg25457927 chr22:38595422 NA -0.37 -7.21 -0.37 3.8e-12 Cutaneous nevi; LUSC cis rs4132509 0.739 rs10803150 chr1:243822600 C/T cg21452805 chr1:244014465 NA 0.64 6.87 0.35 3.15e-11 RR interval (heart rate); LUSC cis rs2859741 0.967 rs822854 chr1:37485788 A/G cg09363841 chr1:37513479 NA -0.39 -7.78 -0.39 9.37e-14 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg14019146 chr3:50243930 SLC38A3 -0.35 -7.74 -0.39 1.2e-13 Intelligence (multi-trait analysis); LUSC cis rs9796 0.553 rs7171437 chr15:41315168 G/A cg18705301 chr15:41695430 NDUFAF1 -0.54 -9.21 -0.45 3.75e-18 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20160885 chr7:5013524 RNF216L 0.4 6.08 0.32 3.26e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7481584 0.962 rs11024766 chr11:2984645 C/G cg08508325 chr11:3079039 CARS 0.3 5.84 0.3 1.23e-8 Calcium levels; LUSC cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -7.08 -0.36 8.66e-12 Psoriasis; LUSC cis rs5769765 0.657 rs8136116 chr22:50256886 T/A cg22709217 chr22:50311962 ALG12;CRELD2 0.62 6.55 0.34 2.16e-10 Schizophrenia; LUSC cis rs208520 0.690 rs12194057 chr6:66745616 A/G cg07460842 chr6:66804631 NA 1.1 17.07 0.68 1.97e-47 Exhaled nitric oxide output; LUSC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg05340658 chr4:99064831 C4orf37 0.69 11.64 0.54 1.62e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg08999081 chr20:33150536 PIGU -0.41 -7.6 -0.38 3.05e-13 Coronary artery disease; LUSC cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg25554036 chr4:6271136 WFS1 0.61 12.78 0.57 1.03e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs6952808 0.756 rs12537348 chr7:1948172 C/G cg04565464 chr8:145669602 NFKBIL2 0.38 6.08 0.32 3.23e-9 Bipolar disorder and schizophrenia; LUSC cis rs899997 1.000 rs11072794 chr15:79006582 A/G cg04896959 chr15:78267971 NA 0.5 10.42 0.5 3.23e-22 Coronary artery disease or large artery stroke; LUSC cis rs859767 0.679 rs4954158 chr2:135426618 T/C cg12500956 chr2:135428796 TMEM163 -0.27 -6.22 -0.32 1.51e-9 Neuroticism; LUSC cis rs9914988 0.943 rs66588554 chr17:27141110 A/G cg09479241 chr17:27052676 TLCD1 0.45 6.12 0.32 2.66e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2806561 0.808 rs4654834 chr1:23364919 T/C cg19743168 chr1:23544995 NA -0.39 -8.08 -0.4 1.16e-14 Height; LUSC cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg00339695 chr16:24857497 SLC5A11 0.39 6.63 0.34 1.36e-10 Intelligence (multi-trait analysis); LUSC cis rs6500395 0.925 rs12920170 chr16:48701530 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.85 -0.35 3.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs3806843 0.966 rs2337986 chr5:140160622 C/T cg26395211 chr5:140044315 WDR55 -0.37 -5.78 -0.3 1.74e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg00599273 chr12:58146742 CDK4 -0.29 -5.73 -0.3 2.19e-8 Multiple sclerosis; LUSC cis rs698813 0.604 rs2340814 chr2:44490977 C/T cg00619915 chr2:44497795 NA -0.53 -7.56 -0.38 4.02e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs10791097 0.694 rs2236711 chr11:130739284 G/A cg12179176 chr11:130786555 SNX19 0.85 14.82 0.63 1.51e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs11264213 0.686 rs12041193 chr1:36412760 C/T cg27506609 chr1:36549197 TEKT2 0.5 7.14 0.36 5.68e-12 Schizophrenia; LUSC cis rs68170813 0.617 rs12535761 chr7:107139275 A/C cg24556660 chr7:106842632 COG5;HBP1 -0.46 -5.7 -0.3 2.7e-8 Coronary artery disease; LUSC cis rs8060686 0.641 rs57408712 chr16:68242573 G/C cg27539214 chr16:67997921 SLC12A4 -0.56 -7.23 -0.37 3.42e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg23306229 chr2:178417860 TTC30B 0.45 5.79 0.3 1.65e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2073300 1.000 rs114718317 chr20:23442620 T/C cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg08132940 chr7:1081526 C7orf50 -0.51 -6.06 -0.31 3.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg26338869 chr17:61819248 STRADA 0.4 5.66 0.3 3.19e-8 Prudent dietary pattern; LUSC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg11764359 chr7:65958608 NA -0.68 -10.47 -0.5 2.3e-22 Aortic root size; LUSC trans rs7939886 0.920 rs11227145 chr11:55839278 C/A cg03929089 chr4:120376271 NA 0.73 6.06 0.31 3.74e-9 Myopia (pathological); LUSC cis rs2303282 0.664 rs4784664 chr16:56447286 T/C cg00500540 chr16:56394104 NA -0.39 -6.6 -0.34 1.6e-10 Breast cancer; LUSC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg17143192 chr8:8559678 CLDN23 0.66 9.6 0.46 2e-19 Obesity-related traits; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07752304 chr19:925903 ARID3A -0.43 -6.49 -0.33 3.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg14668632 chr7:2872130 GNA12 -0.43 -6.13 -0.32 2.43e-9 Height; LUSC cis rs3862435 0.831 rs1042538 chr15:91044408 T/A cg22089800 chr15:90895588 ZNF774 -0.55 -5.85 -0.3 1.16e-8 Response to exercise (triglyceride level interaction); LUSC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg24675658 chr1:53192096 ZYG11B -0.55 -8.44 -0.42 9.6e-16 Monocyte count; LUSC cis rs12760731 0.516 rs12403484 chr1:178129059 C/A cg00404053 chr1:178313656 RASAL2 0.59 5.97 0.31 6.14e-9 Obesity-related traits; LUSC cis rs73195822 0.614 rs17683336 chr12:111212712 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 7.04 0.36 1.13e-11 Itch intensity from mosquito bite; LUSC trans rs225245 0.791 rs3890901 chr17:34011322 A/C cg19694781 chr19:47549865 TMEM160 -0.4 -6.35 -0.33 6.92e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs7824557 0.767 rs17797443 chr8:11164012 T/C cg15556689 chr8:8085844 FLJ10661 0.55 8.43 0.42 1.07e-15 Retinal vascular caliber; LUSC cis rs6785206 0.803 rs6774512 chr3:128415868 C/T cg16766828 chr3:128327626 NA -0.69 -7.62 -0.38 2.63e-13 Lymphocyte percentage of white cells; LUSC cis rs9902453 0.933 rs8080343 chr17:28456758 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.87 0.4 5.08e-14 Coffee consumption (cups per day); LUSC cis rs6969780 1.000 rs6969780 chr7:27159136 G/C cg26364809 chr7:27145159 NA -0.58 -5.98 -0.31 5.74e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs9640161 0.830 rs12703061 chr7:150062545 T/C cg21361702 chr7:150065534 REPIN1 0.59 8.47 0.42 8.11e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg05347473 chr6:146136440 FBXO30 0.52 8.62 0.43 2.77e-16 Lobe attachment (rater-scored or self-reported); LUSC cis rs146009840 1 rs146009840 chr15:78906177 A/T cg18825076 chr15:78729989 IREB2 -0.5 -7.84 -0.39 6.17e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.11 -0.41 9.66e-15 Personality dimensions; LUSC cis rs10876993 0.855 rs10877007 chr12:58100058 T/A cg18357645 chr12:58087776 OS9 0.59 8.98 0.44 2.06e-17 Celiac disease or Rheumatoid arthritis; LUSC cis rs2439831 1.000 rs101094 chr15:43787322 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg10755058 chr3:40428713 ENTPD3 0.36 5.97 0.31 5.99e-9 Renal cell carcinoma; LUSC trans rs8072100 0.666 rs9913503 chr17:45776330 T/G cg04995722 chr7:26192034 NFE2L3 -0.41 -6.23 -0.32 1.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs2887399 0.505 rs10132992 chr14:96225224 C/T cg20659435 chr10:77156218 NA -0.58 -6.03 -0.31 4.29e-9 Mosaic loss of chromosome Y; LUSC trans rs7647973 0.710 rs6797299 chr3:49609794 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 6.98e-13 Menarche (age at onset); LUSC cis rs73200209 0.625 rs11611787 chr12:116644886 G/T cg01776926 chr12:116560359 MED13L -0.5 -6.14 -0.32 2.35e-9 Total body bone mineral density; LUSC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg09359103 chr1:154839909 KCNN3 -0.7 -16.24 -0.66 4.09e-44 Prostate cancer; LUSC cis rs2255336 0.808 rs59611026 chr12:10597986 A/G cg16084090 chr12:10586130 KLRC2 -0.44 -5.65 -0.3 3.5e-8 Blood protein levels; LUSC cis rs727505 0.954 rs1568883 chr7:124710761 G/A cg23710748 chr7:124431027 NA -0.4 -6.98 -0.36 1.63e-11 Lewy body disease; LUSC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg21970626 chr13:21893289 NA -0.47 -8.99 -0.44 1.85e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs16854884 0.586 rs7650172 chr3:143729408 G/C cg01302019 chr3:143689584 C3orf58 -0.34 -5.65 -0.3 3.46e-8 Economic and political preferences (feminism/equality); LUSC cis rs116988415 0.584 rs4902313 chr14:65242164 T/C cg00114569 chr14:65239327 SPTB 0.65 6.55 0.34 2.18e-10 Daytime sleep phenotypes; LUSC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg09044154 chr16:88155775 NA 0.57 7.47 0.38 6.92e-13 Menopause (age at onset); LUSC cis rs314370 0.818 rs12705091 chr7:100472380 C/T cg18683606 chr7:100471612 SRRT 0.46 6.19 0.32 1.78e-9 Resting heart rate; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg01284702 chr19:11039163 C19orf52;YIPF2 -0.45 -6.35 -0.33 6.89e-10 Bipolar disorder and schizophrenia; LUSC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg27494647 chr7:150038898 RARRES2 0.52 7.89 0.4 4.43e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs13006833 0.739 rs291429 chr2:191197941 G/A cg21644426 chr2:191273491 MFSD6 0.43 6.13 0.32 2.52e-9 Urinary metabolites; LUSC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.45 6.11 0.32 2.75e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4704187 0.640 rs4704183 chr5:74471048 C/G cg03227963 chr5:74354835 NA 0.29 6.22 0.32 1.46e-9 Response to amphetamines; LUSC cis rs10845606 1.000 rs10845606 chr12:12834894 G/T cg04607235 chr12:12878440 APOLD1 -0.46 -5.67 -0.3 3.12e-8 Systemic lupus erythematosus; LUSC cis rs72781680 0.898 rs72786278 chr2:24063243 C/T cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg01657329 chr11:68192670 LRP5 -0.43 -6.45 -0.33 3.96e-10 Total body bone mineral density; LUSC cis rs6582630 0.615 rs12821226 chr12:38546406 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.41 -0.33 5.01e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg26162295 chr17:38119207 GSDMA -0.24 -5.77 -0.3 1.86e-8 Self-reported allergy; LUSC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg00509249 chr6:109615579 CCDC162 -0.32 -5.85 -0.3 1.19e-8 Reticulocyte fraction of red cells; LUSC cis rs4280164 0.945 rs11158632 chr14:24769663 A/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.56 -6.63 -0.34 1.36e-10 Parent of origin effect on language impairment (paternal); LUSC cis rs4237845 0.513 rs7134797 chr12:58263852 C/T cg00677455 chr12:58241039 CTDSP2 0.7 10.6 0.5 7.78e-23 Intelligence (multi-trait analysis); LUSC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg03709012 chr19:19516395 GATAD2A 0.87 14.79 0.63 1.95e-38 Tonsillectomy; LUSC cis rs10186029 0.509 rs62187851 chr2:213940374 T/A cg08319019 chr2:214017104 IKZF2 -0.41 -5.89 -0.31 9.48e-9 Systemic sclerosis; LUSC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg03433033 chr1:76189801 ACADM -0.88 -18.7 -0.72 6.89e-54 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg01579765 chr21:45077557 HSF2BP 0.51 10.41 0.49 3.78e-22 Mean corpuscular volume; LUSC cis rs1178968 0.818 rs6957049 chr7:72754037 G/A cg25889504 chr7:72793014 NA 0.59 7.96 0.4 2.69e-14 Triglyceride levels; LUSC cis rs13256369 0.708 rs11783670 chr8:8559394 G/A cg17143192 chr8:8559678 CLDN23 0.64 8.85 0.44 5.04e-17 Obesity-related traits; LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg02018176 chr4:1364513 KIAA1530 0.52 9.06 0.44 1.13e-17 Obesity-related traits; LUSC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg12564285 chr5:131593104 PDLIM4 0.42 7.68 0.39 1.74e-13 Breast cancer; LUSC cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg07061783 chr6:25882402 NA -0.39 -6.06 -0.31 3.75e-9 Blood metabolite levels; LUSC cis rs4698790 0.846 rs11730651 chr4:110718730 T/C cg07850274 chr4:110748770 RRH -0.36 -5.7 -0.3 2.6e-8 Fasting insulin (dietary factor interaction);Homeostasis model assessment of insulin resistance (dietary factor interaction); LUSC cis rs3771570 0.901 rs4675964 chr2:242324760 A/C cg21155796 chr2:242212141 HDLBP 0.51 6.25 0.32 1.28e-9 Prostate cancer; LUSC cis rs11098499 1.000 rs28419773 chr4:120211061 T/C cg09307838 chr4:120376055 NA 0.72 10.36 0.49 5.25e-22 Corneal astigmatism; LUSC cis rs9611519 1.000 rs9611520 chr22:41613303 C/T cg03806693 chr22:41940476 POLR3H -0.54 -7.39 -0.37 1.18e-12 Neuroticism; LUSC cis rs11098499 0.954 rs28685688 chr4:120420334 T/C cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg00509249 chr6:109615579 CCDC162 -0.32 -5.84 -0.3 1.21e-8 Reticulocyte fraction of red cells; LUSC cis rs6963495 0.585 rs1728653 chr7:105191335 A/G cg19920283 chr7:105172520 RINT1 0.5 6.16 0.32 2.07e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2637266 0.935 rs2583059 chr10:78395178 G/C cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.95e-13 Pulmonary function; LUSC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg13010344 chr12:123464640 ARL6IP4 -0.51 -7.89 -0.4 4.39e-14 Platelet count; LUSC cis rs2439831 1.000 rs2251538 chr15:43767209 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg06808227 chr14:105710500 BRF1 -0.64 -9.5 -0.46 4.19e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs7759001 0.857 rs6935118 chr6:27354958 T/A cg18711553 chr6:27366782 ZNF391 0.39 5.74 0.3 2.1e-8 Glomerular filtration rate (creatinine); LUSC cis rs4665809 0.652 rs11685594 chr2:26402846 A/G cg26314531 chr2:26401878 FAM59B -0.71 -9.69 -0.47 1.03e-19 Gut microbiome composition (summer); LUSC cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.35 -6.56 -0.34 2.08e-10 Monocyte percentage of white cells; LUSC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.47 -7.63 -0.39 2.42e-13 Alzheimer's disease (late onset); LUSC cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg07606381 chr6:8435919 SLC35B3 0.72 12.09 0.55 3.77e-28 Motion sickness; LUSC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg02796970 chr10:39023768 NA -0.49 -7.93 -0.4 3.22e-14 Menopause (age at onset); LUSC cis rs968451 0.756 rs1007117 chr22:39675770 G/T cg17798944 chr22:39715225 SNORD43;RPL3 0.67 9.43 0.46 7.29e-19 Primary biliary cholangitis; LUSC cis rs4803468 1.000 rs11883104 chr19:41923799 T/C cg09537434 chr19:41945824 ATP5SL -0.91 -15.89 -0.66 9.36e-43 Height; LUSC trans rs11696501 0.694 rs2171371 chr20:44273482 T/C cg03272292 chr12:48577362 C12orf68 0.49 6.08 0.32 3.2e-9 Brain structure; LUSC cis rs912057 0.965 rs1294409 chr6:6738355 A/G cg06612196 chr6:6737390 NA -0.56 -11.01 -0.52 2.91e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg02018176 chr4:1364513 KIAA1530 0.51 8.68 0.43 1.74e-16 Obesity-related traits; LUSC cis rs9815354 0.669 rs113059632 chr3:41932858 G/A cg03022575 chr3:42003672 ULK4 0.82 8.55 0.42 4.49e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg13010199 chr12:38710504 ALG10B 0.67 10.09 0.48 4.43e-21 Bladder cancer; LUSC cis rs9400467 0.528 rs11153291 chr6:111720130 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.98 -0.36 1.57e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs12579753 0.917 rs11115029 chr12:82202219 C/G cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs12291225 0.585 rs12270374 chr11:14375079 T/C cg19336497 chr11:14380999 RRAS2 -0.61 -14.0 -0.61 2.23e-35 Sense of smell; LUSC cis rs2425143 1.000 rs12481228 chr20:34218673 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.05 -0.31 3.92e-9 Blood protein levels; LUSC cis rs9309473 0.606 rs77962988 chr2:73886090 T/C cg20560298 chr2:73613845 ALMS1 -0.5 -5.81 -0.3 1.47e-8 Metabolite levels; LUSC cis rs7267979 1.000 rs11087520 chr20:25436827 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.09 0.74 2.07e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg09365446 chr1:150670422 GOLPH3L -0.41 -6.05 -0.31 3.97e-9 Tonsillectomy; LUSC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg02574844 chr11:5959923 NA -0.45 -6.31 -0.33 8.71e-10 DNA methylation (variation); LUSC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg04414720 chr1:150670196 GOLPH3L 0.52 8.33 0.41 2.06e-15 Melanoma; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02767759 chr16:30366751 CD2BP2 0.46 6.66 0.34 1.12e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7587476 0.689 rs10498025 chr2:215749256 A/G cg04004882 chr2:215674386 BARD1 0.48 6.03 0.31 4.23e-9 Neuroblastoma; LUSC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg22800045 chr5:56110881 MAP3K1 0.79 10.23 0.49 1.56e-21 Initial pursuit acceleration; LUSC cis rs1559088 0.847 rs2287680 chr19:33608566 A/G cg03563238 chr19:33554763 RHPN2 0.39 6.38 0.33 6.02e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg06001716 chr17:41278141 BRCA1;NBR2 -0.36 -5.74 -0.3 2.12e-8 Menopause (age at onset); LUSC trans rs7829975 0.617 rs4841071 chr8:8791144 G/T cg21775007 chr8:11205619 TDH 0.41 6.26 0.32 1.16e-9 Mood instability; LUSC cis rs295137 0.836 rs10804097 chr2:201104924 A/T cg23649088 chr2:200775458 C2orf69 0.47 7.21 0.37 3.81e-12 Asthma (bronchodilator response); LUSC cis rs77741769 0.529 rs2047568 chr12:121243790 A/G cg02419362 chr12:121203948 SPPL3 -0.45 -8.52 -0.42 5.4e-16 Mean corpuscular volume; LUSC cis rs6752107 1.000 rs6708373 chr2:234172846 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.7 11.56 0.53 3.25e-26 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2710642 0.566 rs2710651 chr2:63166379 G/A cg17519650 chr2:63277830 OTX1 0.66 9.61 0.47 1.84e-19 LDL cholesterol levels;LDL cholesterol; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17940190 chr20:49547700 ADNP 0.41 6.02 0.31 4.48e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs61931739 0.500 rs11053199 chr12:34450534 C/T cg26384229 chr12:38710491 ALG10B -0.81 -13.79 -0.6 1.46e-34 Morning vs. evening chronotype; LUSC cis rs2832077 1.000 rs9983229 chr21:30137674 A/G cg08807101 chr21:30365312 RNF160 0.49 6.33 0.33 8.02e-10 Cognitive test performance; LUSC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg18252515 chr7:66147081 NA 1.24 14.24 0.61 2.72e-36 Diabetic kidney disease; LUSC cis rs5769707 0.609 rs2007024 chr22:49988815 C/T cg05373962 chr22:49881684 NA -0.41 -8.82 -0.43 6.49e-17 Monocyte count;Monocyte percentage of white cells; LUSC cis rs11758351 0.778 rs41266801 chr6:26197493 C/A cg06951627 chr6:26196580 NA 0.52 5.67 0.3 3.14e-8 Gout;Renal underexcretion gout; LUSC cis rs6964587 1.000 rs6465347 chr7:91693837 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.52e-8 Breast cancer; LUSC cis rs7584330 0.737 rs1497129 chr2:238369184 C/T cg14458575 chr2:238380390 NA 0.66 11.52 0.53 4.53e-26 Prostate cancer; LUSC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg17143192 chr8:8559678 CLDN23 0.66 9.64 0.47 1.41e-19 Obesity-related traits; LUSC cis rs601338 1 rs601338 chr19:49206674 G/A cg21064579 chr19:49206444 FUT2 0.47 8.99 0.44 1.94e-17 Number of common colds;Blood metabolite levels;Blood metabolite ratios; LUSC cis rs9300255 0.602 rs4372492 chr12:123697357 T/C cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.93 -0.31 7.68e-9 Neutrophil percentage of white cells; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg03790207 chr6:42947109 PEX6 -0.45 -6.92 -0.35 2.31e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7296418 0.961 rs1790106 chr12:123591596 G/T cg00376283 chr12:123451042 ABCB9 0.81 12.43 0.56 2.11e-29 Platelet count; LUSC cis rs7605827 0.897 rs12692271 chr2:15640317 T/C cg19274914 chr2:15703543 NA 0.46 8.84 0.44 5.74e-17 Educational attainment (years of education); LUSC cis rs6736093 0.966 rs13003919 chr2:112753950 A/G cg12686935 chr2:112915763 FBLN7 0.38 6.11 0.32 2.73e-9 Coronary artery disease; LUSC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.07 0.4 1.29e-14 Breast cancer; LUSC cis rs11229555 0.598 rs4519112 chr11:58176386 C/T cg15696309 chr11:58395628 NA -0.61 -7.54 -0.38 4.58e-13 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs31872 0.597 rs31874 chr5:140369318 C/T cg19650706 chr5:140594406 PCDHB13 0.51 7.08 0.36 8.43e-12 Visceral adipose tissue adjusted for BMI; LUSC cis rs17270561 0.609 rs12529272 chr6:25731342 A/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.08 0.44 9.81e-18 Iron status biomarkers; LUSC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -10.46 -0.5 2.44e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg04539111 chr16:67997858 SLC12A4 -0.46 -6.19 -0.32 1.8e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs1728785 0.792 rs1111502 chr16:68581209 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.56 0.38 3.96e-13 Ulcerative colitis; LUSC cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.78 0.35 5.56e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg15649852 chr7:65879115 NA -0.41 -5.7 -0.3 2.57e-8 Aortic root size; LUSC cis rs7072216 0.922 rs6584191 chr10:100152055 C/G cg26618903 chr10:100175079 PYROXD2 -0.3 -5.86 -0.31 1.08e-8 Metabolite levels; LUSC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg26441486 chr22:50317300 CRELD2 0.36 5.87 0.31 1.06e-8 Schizophrenia; LUSC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg04362960 chr10:104952993 NT5C2 0.58 9.33 0.45 1.49e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6964587 1.000 rs6952389 chr7:91657994 A/G cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.08e-8 Breast cancer; LUSC cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg24642439 chr20:33292090 TP53INP2 0.47 7.17 0.37 4.84e-12 Glomerular filtration rate (creatinine); LUSC cis rs1215050 0.791 rs968854 chr4:98837863 T/C cg05340658 chr4:99064831 C4orf37 0.42 6.68 0.34 9.87e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9311676 0.656 rs11721168 chr3:58408679 G/A cg26110898 chr3:58419937 PDHB 0.4 6.5 0.34 2.9e-10 Systemic lupus erythematosus; LUSC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg13393036 chr8:95962371 TP53INP1 0.44 8.6 0.43 3.05e-16 Type 2 diabetes; LUSC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.23 0.52 4.94e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7804356 0.954 rs10270187 chr7:26885885 C/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg03233332 chr7:66118400 NA 0.41 6.05 0.31 3.95e-9 Aortic root size; LUSC cis rs1443512 0.704 rs4759308 chr12:54329031 A/T cg17410650 chr12:54324560 NA -0.58 -10.45 -0.5 2.58e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC trans rs9329221 0.905 rs17765901 chr8:10249480 G/T cg15556689 chr8:8085844 FLJ10661 -0.63 -9.76 -0.47 5.99e-20 Neuroticism; LUSC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 3.03e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg04944784 chr2:26401820 FAM59B -0.68 -9.46 -0.46 5.61e-19 Gut microbiome composition (summer); LUSC cis rs9326248 0.911 rs474339 chr11:117059552 G/A cg10130564 chr11:117069849 TAGLN 0.38 6.54 0.34 2.34e-10 Blood protein levels; LUSC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg23985595 chr17:80112537 CCDC57 0.34 6.49 0.33 3.03e-10 Life satisfaction; LUSC cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg04545296 chr12:48745243 ZNF641 0.37 6.82 0.35 4.23e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs2012796 0.957 rs8009083 chr14:81818289 A/G cg02996355 chr14:81879375 NA 0.43 6.38 0.33 5.86e-10 Night sleep phenotypes; LUSC trans rs9951602 0.512 rs9955812 chr18:76650954 T/A cg02800362 chr5:177631904 HNRNPAB 0.88 13.11 0.58 5.56e-32 Obesity-related traits; LUSC cis rs9287719 0.967 rs6432112 chr2:10744874 A/G cg00105475 chr2:10696890 NA -0.39 -6.5 -0.34 2.88e-10 Prostate cancer; LUSC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg18477163 chr1:228402036 OBSCN 0.62 12.18 0.55 1.73e-28 Diastolic blood pressure; LUSC cis rs5769707 0.846 rs5770610 chr22:50036897 A/C cg10356904 chr22:49881777 NA -0.33 -7.52 -0.38 5.26e-13 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3540 0.533 rs2256097 chr15:90971331 A/T cg10434728 chr15:90938212 IQGAP1 0.41 8.51 0.42 5.91e-16 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs9929218 0.954 rs9925923 chr16:68819614 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -11.32 -0.53 2.39e-25 Colorectal cancer; LUSC trans rs6030 0.917 rs2301515 chr1:169494196 C/T cg16792071 chr10:134842795 NA 0.28 6.13 0.32 2.43e-9 Uric acid levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03559043 chr19:58898554 RPS5 0.4 6.03 0.31 4.25e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.2 27.87 0.84 3.57e-89 Chronic sinus infection; LUSC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg15704280 chr7:45808275 SEPT13 -0.71 -10.41 -0.49 3.64e-22 Coronary artery disease; LUSC trans rs853679 0.546 rs483143 chr6:27846744 G/C cg01620082 chr3:125678407 NA -0.69 -6.87 -0.35 3.12e-11 Depression; LUSC cis rs9942416 0.660 rs60423072 chr5:75006113 T/A cg19683494 chr5:74908142 NA 0.44 6.67 0.34 1.05e-10 Age-related disease endophenotypes; LUSC cis rs6964587 0.933 rs10271174 chr7:91785970 A/G cg17063962 chr7:91808500 NA 0.6 9.52 0.46 3.52e-19 Breast cancer; LUSC cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.31e-41 Bladder cancer; LUSC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg23283495 chr1:209979779 IRF6 0.45 7.22 0.37 3.52e-12 Monobrow; LUSC cis rs8072100 0.544 rs9284377 chr17:45386412 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.34 -5.78 -0.3 1.67e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.31e-11 Schizophrenia; LUSC cis rs950776 0.518 rs12914694 chr15:78814444 G/A cg06917634 chr15:78832804 PSMA4 0.83 14.96 0.63 4.36e-39 Sudden cardiac arrest; LUSC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg06636001 chr8:8085503 FLJ10661 0.6 9.52 0.46 3.69e-19 Mood instability; LUSC cis rs614226 0.935 rs7956998 chr12:120994932 G/A cg27489772 chr12:121021490 NA 0.6 7.92 0.4 3.5e-14 Type 1 diabetes nephropathy; LUSC cis rs8077889 0.956 rs61608877 chr17:41848713 A/C cg26893861 chr17:41843967 DUSP3 0.88 13.37 0.59 6.01e-33 Triglycerides; LUSC cis rs7527798 0.592 rs960086 chr1:207827069 A/G cg09232269 chr1:207846808 CR1L -0.3 -6.39 -0.33 5.46e-10 Erythrocyte sedimentation rate; LUSC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg06740227 chr12:86229804 RASSF9 -0.37 -5.87 -0.31 1.05e-8 Major depressive disorder; LUSC cis rs354225 0.673 rs354232 chr2:54916910 C/A cg26097391 chr2:54893211 SPTBN1 0.37 6.02 0.31 4.68e-9 Schizophrenia; LUSC cis rs7568458 0.905 rs10172544 chr2:85788270 C/A cg02493740 chr2:85810744 VAMP5 -0.31 -5.68 -0.3 2.94e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs59698941 0.943 rs79586717 chr5:132251790 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs7188861 0.723 rs12599908 chr16:11395915 G/A cg00044050 chr16:11439710 C16orf75 0.56 6.23 0.32 1.42e-9 HDL cholesterol; LUSC cis rs9503598 0.636 rs7775474 chr6:3468224 T/C cg00476032 chr6:3446245 SLC22A23 0.31 6.12 0.32 2.59e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); LUSC cis rs4845459 0.967 rs6693105 chr1:152590663 C/T cg08895932 chr1:152778580 LCE1C 0.37 6.3 0.33 9.43e-10 Psoriasis; LUSC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.57 -0.34 1.93e-10 High light scatter reticulocyte count; LUSC cis rs4919087 1.000 rs4919090 chr10:99088419 C/G cg25902810 chr10:99078978 FRAT1 -0.46 -6.65 -0.34 1.18e-10 Monocyte count; LUSC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC trans rs9650657 0.707 rs7814757 chr8:10675188 T/C cg15556689 chr8:8085844 FLJ10661 -0.41 -6.26 -0.32 1.2e-9 Neuroticism; LUSC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg14668632 chr7:2872130 GNA12 -0.42 -6.12 -0.32 2.67e-9 Height; LUSC cis rs7575217 0.884 rs1192786 chr2:101783556 A/G cg23907051 chr2:101730305 TBC1D8 -0.27 -6.56 -0.34 2.06e-10 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs12618769 0.597 rs72821920 chr2:99111591 A/G cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg21132104 chr15:45694354 SPATA5L1 0.56 7.75 0.39 1.08e-13 Homoarginine levels; LUSC cis rs4363385 0.693 rs689008 chr1:153047100 G/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.39 -0.37 1.19e-12 Inflammatory skin disease; LUSC cis rs6918586 0.636 rs198817 chr6:26126524 A/G cg17691542 chr6:26056736 HIST1H1C 0.4 5.88 0.31 9.77e-9 Schizophrenia; LUSC cis rs9467711 0.659 rs35304979 chr6:26356347 C/A cg09904177 chr6:26538194 HMGN4 -0.7 -6.74 -0.35 7.15e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg19230755 chr7:65878503 NA 0.41 5.82 0.3 1.39e-8 Aortic root size; LUSC cis rs7712401 0.502 rs30066 chr5:122293702 A/G cg19077854 chr5:122220652 SNX24 0.4 8.56 0.42 4.32e-16 Mean platelet volume; LUSC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.67 0.57 2.52e-30 Alzheimer's disease; LUSC cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg03676636 chr4:99064102 C4orf37 0.27 5.84 0.3 1.24e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg16240275 chr20:61666158 NCRNA00029 0.42 9.28 0.45 2.13e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs4664308 0.967 rs17241973 chr2:160918601 A/G cg03641300 chr2:160917029 PLA2R1 -0.69 -11.71 -0.54 9.36e-27 Idiopathic membranous nephropathy; LUSC cis rs2806561 0.734 rs667211 chr1:23516142 T/C cg19743168 chr1:23544995 NA 0.4 7.89 0.4 4.25e-14 Height; LUSC cis rs1975974 0.574 rs17052370 chr17:21736353 A/G cg18423549 chr17:21743878 NA 0.58 9.18 0.45 4.5e-18 Psoriasis; LUSC trans rs61931739 0.500 rs7312938 chr12:34378708 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.28 0.64 2.34e-40 Morning vs. evening chronotype; LUSC cis rs6456156 0.586 rs12527827 chr6:167469271 C/T cg25258033 chr6:167368657 RNASET2 0.37 5.83 0.3 1.28e-8 Primary biliary cholangitis; LUSC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg18131467 chr2:239335373 ASB1 -1.03 -25.09 -0.81 7.71e-79 Multiple system atrophy; LUSC cis rs2180341 0.521 rs12189967 chr6:127718058 G/A cg24812749 chr6:127587940 RNF146 0.5 7.22 0.37 3.46e-12 Breast cancer; LUSC cis rs2797160 1.000 rs6933302 chr6:126016951 T/C cg05901451 chr6:126070800 HEY2 0.57 8.57 0.42 3.96e-16 Endometrial cancer; LUSC cis rs7582720 1.000 rs72936838 chr2:203772984 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.42 0.42 1.16e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg03161606 chr19:29218774 NA 0.62 8.83 0.44 6.02e-17 Methadone dose in opioid dependence; LUSC cis rs11958404 0.932 rs72816588 chr5:157434390 C/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs34779708 0.966 rs17591781 chr10:35498538 G/A cg03585969 chr10:35415529 CREM 0.64 9.51 0.46 4e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3791556 1.000 rs3791562 chr2:240113436 C/T cg03281426 chr2:240109471 HDAC4 0.51 6.05 0.31 3.98e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9653442 0.609 rs2576678 chr2:100704810 T/C cg22139774 chr2:100720529 AFF3 -0.5 -8.64 -0.43 2.32e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs17608059 0.524 rs9897978 chr17:13900256 G/T cg11395062 chr17:14139857 CDRT15 -0.41 -5.8 -0.3 1.53e-8 Temperament; LUSC cis rs2346177 0.542 rs1900591 chr2:46697968 C/T cg02822958 chr2:46747628 ATP6V1E2 0.48 8.51 0.42 6.04e-16 HDL cholesterol; LUSC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg01341218 chr17:43662625 NA 0.76 11.13 0.52 1.07e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7246967 0.611 rs3853652 chr19:22871913 C/G cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs748404 0.650 rs518234 chr15:43573421 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.43 5.96 0.31 6.38e-9 Lung cancer; LUSC cis rs7605827 0.930 rs2111454 chr2:15522331 G/A cg19274914 chr2:15703543 NA 0.45 8.79 0.43 7.98e-17 Educational attainment (years of education); LUSC cis rs9379850 0.528 rs67575965 chr6:26196593 A/G cg01420254 chr6:26195488 NA 0.56 6.92 0.35 2.32e-11 Intelligence (multi-trait analysis); LUSC cis rs7246967 0.611 rs12984903 chr19:22833881 A/G cg23217946 chr19:22817039 ZNF492 0.49 6.88 0.35 2.88e-11 Bronchopulmonary dysplasia; LUSC cis rs7100689 0.784 rs17678947 chr10:82136333 T/C cg01528321 chr10:82214614 TSPAN14 1.01 15.61 0.65 1.22e-41 Post bronchodilator FEV1; LUSC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.35 0.33 6.93e-10 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg09365446 chr1:150670422 GOLPH3L 0.52 7.46 0.38 7.38e-13 Melanoma; LUSC cis rs4253772 0.938 rs78336060 chr22:46641597 C/T cg18190219 chr22:46762943 CELSR1 -0.52 -6.02 -0.31 4.71e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08554302 chr11:73308756 FAM168A 0.42 6.12 0.32 2.69e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9399401 0.633 rs6570511 chr6:142757368 G/A cg03128060 chr6:142623767 GPR126 0.52 8.95 0.44 2.56e-17 Chronic obstructive pulmonary disease; LUSC cis rs477692 0.692 rs7905095 chr10:131448143 C/T cg05714579 chr10:131428358 MGMT -0.64 -10.18 -0.49 2.16e-21 Response to temozolomide; LUSC cis rs7809950 1.000 rs987391 chr7:107100794 C/G cg23024343 chr7:107201750 COG5 -0.54 -8.71 -0.43 1.42e-16 Coronary artery disease; LUSC cis rs7113850 0.541 rs76344090 chr11:24223375 C/G ch.11.24196551F chr11:24239977 NA 1.01 8.96 0.44 2.3e-17 Bone fracture in osteoporosis; LUSC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.6 -5.73 -0.3 2.26e-8 Cerebrospinal P-tau181p levels; LUSC cis rs3808502 0.549 rs7831039 chr8:11427637 A/T cg21775007 chr8:11205619 TDH -0.58 -8.49 -0.42 6.96e-16 Neuroticism; LUSC cis rs75229567 0.717 rs77874289 chr12:70234203 A/G cg10114359 chr12:70132523 RAB3IP 1.19 10.48 0.5 2.14e-22 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs9677476 1.000 rs12621567 chr2:232118813 T/C cg07929768 chr2:232055508 NA 0.31 5.78 0.3 1.7e-8 Food antigen IgG levels; LUSC cis rs7605827 0.930 rs10207209 chr2:15512701 A/G cg19274914 chr2:15703543 NA 0.46 8.88 0.44 4.27e-17 Educational attainment (years of education); LUSC cis rs1348850 0.793 rs13027299 chr2:178455501 T/G cg22681709 chr2:178499509 PDE11A -0.47 -8.43 -0.42 1.02e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg09263875 chr16:632152 PIGQ 0.71 13.23 0.59 2.01e-32 Height; LUSC cis rs2282300 0.739 rs1765139 chr11:30353725 T/C cg25418670 chr11:30344373 C11orf46 -0.64 -9.29 -0.45 2.08e-18 Morning vs. evening chronotype; LUSC cis rs36093844 0.706 rs75334800 chr11:85586581 A/G cg25872744 chr11:85566296 CCDC83 -0.46 -5.98 -0.31 5.87e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs11779988 0.629 rs11780813 chr8:17856014 T/C cg01800426 chr8:17659068 MTUS1 -0.53 -6.72 -0.35 7.95e-11 Breast cancer; LUSC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg27539214 chr16:67997921 SLC12A4 -0.57 -7.54 -0.38 4.58e-13 HDL cholesterol;Metabolic syndrome; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg08856697 chr17:61627902 DCAF7 -0.57 -6.96 -0.36 1.78e-11 Cognitive function;Information processing speed; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10071973 chr17:16557188 ZNF624 -0.4 -5.97 -0.31 5.99e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6545977 0.527 rs2710647 chr2:63213970 T/C cg17519650 chr2:63277830 OTX1 0.83 12.66 0.57 2.74e-30 Prostate cancer; LUSC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.75 0.35 6.74e-11 Hip circumference adjusted for BMI; LUSC cis rs2625529 0.652 rs12148078 chr15:72300471 G/C cg16672083 chr15:72433130 SENP8 0.51 8.3 0.41 2.58e-15 Red blood cell count; LUSC cis rs11105298 1.000 rs11105298 chr12:89876143 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.43 5.97 0.31 5.9e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1372520 0.766 rs2583961 chr4:90779758 A/G cg15133208 chr4:90757351 SNCA -0.54 -8.24 -0.41 3.96e-15 Neuroticism; LUSC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg08219700 chr8:58056026 NA 0.5 6.59 0.34 1.67e-10 Developmental language disorder (linguistic errors); LUSC cis rs8077889 0.871 rs7212648 chr17:41917962 A/C cg26893861 chr17:41843967 DUSP3 0.92 14.77 0.63 2.45e-38 Triglycerides; LUSC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg26695010 chr11:65641043 EFEMP2 0.42 6.07 0.32 3.38e-9 Breast cancer; LUSC cis rs524023 0.957 rs10792443 chr11:64395252 G/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.21 -0.49 1.79e-21 Urate levels in obese individuals; LUSC cis rs9300255 0.602 rs1727314 chr12:123640664 C/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.14 -0.32 2.38e-9 Neutrophil percentage of white cells; LUSC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg07636037 chr3:49044803 WDR6 1.07 17.58 0.69 1.94e-49 Parkinson's disease; LUSC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.57 -0.34 1.92e-10 Lung cancer; LUSC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg27588902 chr6:42928151 GNMT -0.29 -6.49 -0.33 3.11e-10 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2115630 0.967 rs8028490 chr15:85277888 G/A cg09876464 chr15:85330779 ZNF592 0.36 6.7 0.34 8.83e-11 P wave terminal force; LUSC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.19 -0.32 1.8e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg05861140 chr6:150128134 PCMT1 -0.39 -5.95 -0.31 6.76e-9 Lung cancer; LUSC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg06740227 chr12:86229804 RASSF9 0.45 7.26 0.37 2.81e-12 Major depressive disorder; LUSC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC trans rs7615952 0.932 rs3811679 chr3:125648283 A/G cg07211511 chr3:129823064 LOC729375 -1.25 -20.35 -0.74 1.98e-60 Blood pressure (smoking interaction); LUSC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg22166914 chr1:53195759 ZYG11B 0.71 12.47 0.56 1.46e-29 Monocyte count; LUSC trans rs11696501 0.694 rs6073823 chr20:44256910 G/C cg03272292 chr12:48577362 C12orf68 0.49 6.02 0.31 4.69e-9 Brain structure; LUSC cis rs4332037 0.539 rs55988458 chr7:2059761 G/A cg23422044 chr7:1970798 MAD1L1 -0.57 -6.29 -0.33 1.02e-9 Bipolar disorder; LUSC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg17724175 chr1:150552817 MCL1 -0.37 -6.74 -0.35 7e-11 Tonsillectomy; LUSC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.78 -10.93 -0.51 5.6e-24 Alzheimer's disease; LUSC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg07677032 chr17:61819896 STRADA 0.53 8.92 0.44 3.03e-17 Prudent dietary pattern; LUSC trans rs2243480 1.000 rs35820085 chr7:65442758 C/T cg10756647 chr7:56101905 PSPH 0.86 8.36 0.42 1.7e-15 Diabetic kidney disease; LUSC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg15147215 chr3:52552868 STAB1 -0.29 -5.75 -0.3 2.05e-8 Bipolar disorder; LUSC cis rs17095355 0.901 rs7069128 chr10:111760075 C/T cg00817464 chr10:111662876 XPNPEP1 0.58 7.24 0.37 3.09e-12 Biliary atresia; LUSC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg14196790 chr5:131705035 SLC22A5 0.44 7.02 0.36 1.22e-11 Breast cancer;Mosquito bite size; LUSC cis rs5167 0.781 rs2075619 chr19:45495682 A/G cg20090143 chr19:45452003 APOC2 0.34 5.81 0.3 1.44e-8 Blood protein levels; LUSC cis rs9815354 0.812 rs73071325 chr3:41809989 T/G cg03022575 chr3:42003672 ULK4 0.83 8.34 0.41 2.04e-15 Pulse pressure;Diastolic blood pressure; LUSC cis rs4499344 0.730 rs10410888 chr19:33103328 G/A cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs72772090 0.520 rs56325109 chr5:96112295 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -7.27 -0.37 2.59e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs17030434 0.654 rs1530105 chr4:154646994 C/T cg14289246 chr4:154710475 SFRP2 0.47 6.45 0.33 3.82e-10 Electrocardiographic conduction measures; LUSC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg26924012 chr15:45694286 SPATA5L1 1.13 20.89 0.75 1.35e-62 Homoarginine levels; LUSC cis rs67539049 1.000 rs66934548 chr8:11304050 C/A cg02771117 chr8:11279352 FAM167A;C8orf12 -0.43 -6.57 -0.34 1.98e-10 Itch intensity from mosquito bite; LUSC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg24531977 chr5:56204891 C5orf35 0.87 13.83 0.6 1.01e-34 Initial pursuit acceleration; LUSC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg06219351 chr7:158114137 PTPRN2 0.49 8.87 0.44 4.61e-17 Calcium levels; LUSC cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 5.82 0.3 1.41e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6500602 0.702 rs4786511 chr16:4571645 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs7568458 0.811 rs3755015 chr2:85764041 G/A cg23752985 chr2:85803571 VAMP8 0.32 6.59 0.34 1.71e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs9660992 0.762 rs1172130 chr1:205244953 G/A cg00857998 chr1:205179979 DSTYK 0.59 9.0 0.44 1.73e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6696846 0.749 rs7515178 chr1:205084120 G/A cg21643547 chr1:205240462 TMCC2 -0.37 -6.93 -0.35 2.12e-11 Red blood cell count; LUSC cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.22 29.6 0.85 2.14e-95 Chronic sinus infection; LUSC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg07741184 chr6:167504864 NA -0.39 -7.09 -0.36 7.89e-12 Crohn's disease; LUSC cis rs362296 0.698 rs3095072 chr4:3263325 G/A cg14583973 chr4:3374767 RGS12 -0.32 -6.22 -0.32 1.49e-9 Parental longevity (mother's age at death); LUSC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.19 0.45 4.24e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7945705 0.818 rs10769948 chr11:8761782 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -11.25 -0.52 3.99e-25 Hemoglobin concentration; LUSC trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs7726839 0.540 rs3749618 chr5:602650 A/G cg11887960 chr12:57824829 NA 0.54 6.67 0.34 1.09e-10 Obesity-related traits; LUSC cis rs7914558 1.000 rs11191577 chr10:104902165 A/G cg23093090 chr10:104574429 C10orf26 -0.38 -7.11 -0.36 6.9e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg09835421 chr16:68378352 PRMT7 -0.55 -6.26 -0.32 1.19e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs61931739 0.749 rs7315233 chr12:34271975 G/T cg06521331 chr12:34319734 NA -0.39 -6.67 -0.34 1.05e-10 Morning vs. evening chronotype; LUSC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.46 6.39 0.33 5.52e-10 Renal function-related traits (BUN); LUSC cis rs7940866 0.874 rs10791113 chr11:130873165 A/G cg12179176 chr11:130786555 SNX19 0.64 9.98 0.48 1.08e-20 Schizophrenia; LUSC cis rs72781680 0.898 rs72796166 chr2:23939311 G/C cg20701182 chr2:24300061 SF3B14 0.74 7.33 0.37 1.77e-12 Lymphocyte counts; LUSC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.34 0.53 1.96e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3820928 1.000 rs59904960 chr2:227761269 T/C cg11843606 chr2:227700838 RHBDD1 -0.54 -7.96 -0.4 2.72e-14 Pulmonary function; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg18796520 chr12:4758272 NDUFA9 -0.38 -6.04 -0.31 4.06e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7903847 0.642 rs11189174 chr10:99139600 C/G cg20016023 chr10:99160130 RRP12 -0.33 -8.17 -0.41 6.41e-15 Granulocyte percentage of myeloid white cells; LUSC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg12615879 chr12:58013172 SLC26A10 -0.27 -5.77 -0.3 1.78e-8 Multiple sclerosis; LUSC cis rs9837602 0.810 rs35885423 chr3:99813218 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.31 0.33 8.81e-10 Breast cancer; LUSC cis rs11809207 0.903 rs17257148 chr1:26526348 G/C cg00147160 chr1:26503991 CNKSR1 0.39 6.67 0.34 1.07e-10 Height; LUSC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg15595755 chr5:1867978 NA 0.47 8.58 0.42 3.71e-16 Cardiovascular disease risk factors; LUSC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.08 -0.36 8.5e-12 Blood metabolite levels; LUSC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg08888203 chr3:10149979 C3orf24 -0.61 -8.83 -0.44 5.99e-17 Alzheimer's disease; LUSC cis rs7177699 0.557 rs9920968 chr15:79118747 G/A cg15571903 chr15:79123663 NA 0.32 5.94 0.31 6.97e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs10911232 0.507 rs4129857 chr1:183004547 C/T ch.1.3577855R chr1:183094577 LAMC1 0.71 10.93 0.51 5.67e-24 Hypertriglyceridemia; LUSC cis rs1670533 1.000 rs6857085 chr4:1095920 C/A cg27284194 chr4:1044797 NA -0.57 -8.22 -0.41 4.41e-15 Recombination rate (females); LUSC trans rs12599106 0.702 rs237997 chr16:34686820 G/A cg11235426 chr6:292522 DUSP22 0.43 6.48 0.33 3.35e-10 Menopause (age at onset); LUSC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg00745463 chr17:30367425 LRRC37B -0.79 -9.11 -0.45 7.81e-18 Hip circumference adjusted for BMI; LUSC cis rs2629540 0.889 rs10901808 chr10:126399159 A/C cg08799069 chr10:126477246 METTL10 0.6 8.26 0.41 3.41e-15 Cocaine dependence; LUSC cis rs9341808 0.667 rs1408292 chr6:80883906 G/T cg08355045 chr6:80787529 NA 0.49 8.39 0.42 1.38e-15 Sitting height ratio; LUSC cis rs2279817 0.780 rs79136279 chr1:18008121 C/T cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.13 -0.32 2.54e-9 Neuroticism; LUSC trans rs17685 0.623 rs7782808 chr7:75768645 C/T cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg07606381 chr6:8435919 SLC35B3 0.75 12.72 0.57 1.74e-30 Motion sickness; LUSC cis rs17253792 0.822 rs77033617 chr14:56129746 T/A cg01858014 chr14:56050164 KTN1 -0.79 -6.68 -0.34 9.73e-11 Putamen volume; LUSC cis rs11112613 0.609 rs11112632 chr12:106041887 A/G cg03607813 chr12:105948248 NA -0.63 -8.07 -0.4 1.32e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs6598955 0.572 rs12089219 chr1:26638751 C/T cg00852783 chr1:26633632 UBXN11 -0.5 -5.73 -0.3 2.21e-8 Obesity-related traits; LUSC cis rs4654899 0.758 rs3820326 chr1:21277141 G/A cg01072550 chr1:21505969 NA -0.53 -8.03 -0.4 1.67e-14 Superior frontal gyrus grey matter volume; LUSC cis rs6982240 0.514 rs9324543 chr8:142275662 T/C cg00131261 chr8:142287264 NA -0.36 -6.05 -0.31 3.99e-9 Tonsillectomy; LUSC cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg26384229 chr12:38710491 ALG10B -0.91 -15.5 -0.65 3.31e-41 Bladder cancer; LUSC cis rs2439831 1.000 rs1814538 chr15:43759774 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.98 -11.49 -0.53 5.67e-26 Lung cancer in ever smokers; LUSC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.16 -0.32 2.13e-9 Life satisfaction; LUSC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg04248312 chr19:17393744 ANKLE1 -1.02 -16.53 -0.67 2.81e-45 Systemic lupus erythematosus; LUSC cis rs6546537 0.955 rs1396798 chr2:69887837 G/T cg10773587 chr2:69614142 GFPT1 -0.49 -7.55 -0.38 4.12e-13 Serum thyroid-stimulating hormone levels; LUSC cis rs77106637 0.932 rs7109082 chr11:72707441 A/C cg03878208 chr11:72483293 STARD10 0.58 7.57 0.38 3.77e-13 Type 2 diabetes; LUSC cis rs193541 0.632 rs154503 chr5:122204499 G/A cg19077854 chr5:122220652 SNX24 0.37 7.73 0.39 1.23e-13 Glucose homeostasis traits; LUSC cis rs1113500 0.548 rs11185271 chr1:108659933 A/G cg06207961 chr1:108661230 NA 0.4 6.64 0.34 1.3e-10 Growth-regulated protein alpha levels; LUSC cis rs6484504 0.779 rs16921914 chr11:31210771 G/A cg26647111 chr11:31128758 NA -0.45 -5.83 -0.3 1.3e-8 Red blood cell count; LUSC trans rs12579753 0.917 rs2401003 chr12:82215192 G/A cg07923666 chr12:49932857 KCNH3 -0.48 -5.96 -0.31 6.5e-9 Resting heart rate; LUSC cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg15423357 chr2:25149977 NA 0.35 6.43 0.33 4.46e-10 Body mass index; LUSC cis rs73198271 0.960 rs73198286 chr8:8612022 C/T cg01851573 chr8:8652454 MFHAS1 0.59 8.29 0.41 2.75e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg24846343 chr22:24311635 DDTL 0.67 13.9 0.61 5.45e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs6920965 0.507 rs9401853 chr6:126215197 A/T cg05901451 chr6:126070800 HEY2 -0.52 -7.64 -0.39 2.37e-13 High light scatter reticulocyte count; LUSC cis rs2540226 0.935 rs2540228 chr2:39954632 A/C cg23576258 chr2:39999331 THUMPD2 -0.35 -6.01 -0.31 4.83e-9 Personality dimensions; LUSC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg02038168 chr22:39784481 NA -0.42 -6.11 -0.32 2.79e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11785400 0.701 rs9297968 chr8:143723009 A/G cg10596483 chr8:143751796 JRK 0.52 7.52 0.38 4.98e-13 Schizophrenia; LUSC cis rs7100689 0.622 rs7897994 chr10:82133304 T/G cg00277334 chr10:82204260 NA -0.52 -7.74 -0.39 1.21e-13 Post bronchodilator FEV1; LUSC cis rs4631830 0.720 rs113082846 chr10:51502802 G/C cg20129853 chr10:51489980 NA -0.36 -7.64 -0.39 2.33e-13 Prostate-specific antigen levels; LUSC cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg18681998 chr4:17616180 MED28 0.88 15.6 0.65 1.32e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4714291 0.862 rs2984445 chr6:40069935 C/T cg02267698 chr19:7991119 CTXN1 -0.56 -8.45 -0.42 8.83e-16 Strep throat; LUSC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.04 0.48 6.92e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs295140 1.000 rs7578220 chr2:201183701 A/G cg04283868 chr2:201171347 SPATS2L 0.42 6.4 0.33 5.36e-10 QT interval; LUSC cis rs394563 0.602 rs409099 chr6:149766863 T/G cg03678062 chr6:149772716 ZC3H12D -0.33 -6.91 -0.35 2.54e-11 Dupuytren's disease; LUSC cis rs8060686 0.545 rs74629553 chr16:68176415 C/A cg27539214 chr16:67997921 SLC12A4 -0.59 -7.2 -0.37 3.99e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs208520 1.000 rs208520 chr6:66952828 G/T cg07460842 chr6:66804631 NA -0.95 -12.41 -0.56 2.52e-29 Exhaled nitric oxide output; LUSC cis rs62400317 0.859 rs62438877 chr6:45089064 A/G cg20913747 chr6:44695427 NA -0.46 -7.41 -0.38 1.06e-12 Total body bone mineral density; LUSC cis rs4400599 0.608 rs4845609 chr1:154181954 G/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.99 -0.31 5.4e-9 Platelet distribution width; LUSC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg19729930 chr2:74357872 NA 0.93 17.79 0.7 2.93e-50 Gestational age at birth (maternal effect); LUSC cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.25 0.66 3.56e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.735 rs12903874 chr15:76693318 A/T cg23625390 chr15:77176239 SCAPER -0.6 -9.47 -0.46 5.28e-19 Blood metabolite levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13595813 chr7:86974922 TP53TG1;CROT 0.45 5.99 0.31 5.32e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6591182 0.967 rs11227229 chr11:65354150 C/T cg05805236 chr11:65401703 PCNXL3 -0.36 -5.69 -0.3 2.73e-8 Non-alcoholic fatty liver disease histology (lobular); LUSC cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg07424592 chr7:64974309 NA 0.71 6.19 0.32 1.72e-9 Diabetic kidney disease; LUSC cis rs17253792 0.822 rs8013831 chr14:56172898 G/A cg01858014 chr14:56050164 KTN1 -0.73 -6.12 -0.32 2.67e-9 Putamen volume; LUSC cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg26061582 chr7:22766209 IL6 0.42 6.24 0.32 1.31e-9 Lung cancer; LUSC cis rs7106204 0.609 rs12785699 chr11:24280489 C/T ch.11.24196551F chr11:24239977 NA 0.71 6.05 0.31 3.93e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9611565 0.649 rs139559 chr22:42191636 A/G cg03806693 chr22:41940476 POLR3H -0.85 -12.52 -0.57 9.81e-30 Vitiligo; LUSC cis rs11190604 1.000 rs10883501 chr10:102238326 A/G cg16342193 chr10:102329863 NA -0.35 -6.32 -0.33 8.52e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg21280719 chr6:42927975 GNMT 0.27 6.73 0.35 7.26e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg18681998 chr4:17616180 MED28 0.86 15.53 0.65 2.48e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg06634786 chr22:41940651 POLR3H 0.49 5.72 0.3 2.38e-8 Vitiligo; LUSC cis rs6700896 0.931 rs12021623 chr1:66153586 A/C cg04111102 chr1:66153794 NA 0.33 7.19 0.37 4.18e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg19774624 chr17:42201019 HDAC5 -0.78 -12.05 -0.55 5.39e-28 Total body bone mineral density; LUSC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -11.9 -0.55 1.77e-27 Extrinsic epigenetic age acceleration; LUSC trans rs6076960 0.713 rs3865568 chr20:6249339 A/G cg17788362 chr6:86352627 SYNCRIP 0.46 6.55 0.34 2.2e-10 Smooth-surface caries; LUSC cis rs601339 1.000 rs630408 chr12:123172822 C/T cg11919336 chr12:123188078 GPR109A 0.44 6.58 0.34 1.78e-10 Adiponectin levels; LUSC cis rs1997103 1.000 rs10228182 chr7:55406695 A/T cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg00409521 chr11:89956229 CHORDC1 0.4 6.08 0.32 3.33e-9 Asthma; LUSC trans rs853679 1.000 rs1419183 chr6:28242794 A/C cg06606381 chr12:133084897 FBRSL1 -0.57 -6.81 -0.35 4.67e-11 Depression; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg15271594 chr3:52029932 RPL29 0.45 6.23 0.32 1.44e-9 Mosquito bite size; LUSC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg08493051 chr2:3487164 NA -0.56 -8.8 -0.43 7.33e-17 Neurofibrillary tangles; LUSC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs950027 0.787 rs1547487 chr15:45723983 A/G cg14582100 chr15:45693742 SPATA5L1 0.41 7.51 0.38 5.61e-13 Response to fenofibrate (adiponectin levels); LUSC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg13114125 chr14:105738426 BRF1 -0.94 -15.89 -0.66 9.91e-43 Mean platelet volume;Platelet distribution width; LUSC cis rs295137 0.799 rs4145969 chr2:201139961 C/T cg04283868 chr2:201171347 SPATS2L 0.41 5.95 0.31 6.88e-9 Asthma (bronchodilator response); LUSC trans rs1532331 0.898 rs13665 chr5:43175953 C/G cg17870909 chr21:47566968 FTCD 0.26 6.11 0.32 2.73e-9 Menarche (age at onset); LUSC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg17968037 chr7:100024898 ZCWPW1 -0.41 -6.17 -0.32 2.02e-9 Platelet count; LUSC cis rs6121246 0.567 rs6058203 chr20:30198979 C/T cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.94e-10 Mean corpuscular hemoglobin; LUSC cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg22681709 chr2:178499509 PDE11A -0.59 -11.54 -0.53 3.64e-26 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg12560992 chr17:57184187 TRIM37 0.9 17.84 0.7 1.78e-50 Intelligence (multi-trait analysis); LUSC cis rs362272 0.524 rs7435601 chr4:3369645 A/G cg18352616 chr4:3374830 RGS12 0.3 6.03 0.31 4.45e-9 Serum sulfate level; LUSC cis rs9814567 1.000 rs2370578 chr3:134199612 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.57 -0.6 1.03e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs3126085 0.877 rs12065368 chr1:152253497 C/T cg26876637 chr1:152193138 HRNR 0.45 6.08 0.32 3.31e-9 Atopic dermatitis; LUSC cis rs354225 0.544 rs12713264 chr2:54805218 A/C cg26097391 chr2:54893211 SPTBN1 -0.46 -6.96 -0.36 1.84e-11 Schizophrenia; LUSC cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs644148 0.902 rs12982159 chr19:44964300 C/T cg15540054 chr19:45004280 ZNF180 -0.58 -8.37 -0.42 1.64e-15 Personality dimensions; LUSC cis rs950027 0.549 rs1719250 chr15:45609773 A/G cg26924012 chr15:45694286 SPATA5L1 0.73 11.19 0.52 6.75e-25 Response to fenofibrate (adiponectin levels); LUSC cis rs11030122 0.702 rs1452047 chr11:3991648 A/C cg18678763 chr11:4115507 RRM1 -0.45 -5.77 -0.3 1.82e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 8.12 0.41 9.26e-15 Iron status biomarkers; LUSC cis rs13315871 1.000 rs13317835 chr3:58383275 C/T cg20936604 chr3:58311152 NA -0.65 -6.04 -0.31 4.06e-9 Cholesterol, total; LUSC cis rs11690935 1.000 rs312924 chr2:172564021 A/T cg13550731 chr2:172543902 DYNC1I2 0.8 13.19 0.59 2.79e-32 Schizophrenia; LUSC cis rs4566357 0.615 rs10174591 chr2:227913140 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -8.27 -0.41 3.17e-15 Coronary artery disease; LUSC cis rs12893668 0.703 rs7140568 chr14:104041374 C/T cg01849466 chr14:104193079 ZFYVE21 -0.47 -6.49 -0.33 3.08e-10 Reticulocyte count; LUSC cis rs7168353 1.000 rs7168353 chr15:93638401 C/G cg04697454 chr15:93633408 RGMA 0.34 5.94 0.31 7.23e-9 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs7524258 0.867 rs916392 chr1:7271930 T/C cg07173049 chr1:7289937 CAMTA1 0.36 7.49 0.38 6.4e-13 Tourette's syndrome or obsessive-compulsive disorder; LUSC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.53 0.38 4.76e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg20406979 chr6:167373233 NA 0.25 5.81 0.3 1.49e-8 Crohn's disease; LUSC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg27535305 chr1:53392650 SCP2 -0.39 -7.28 -0.37 2.42e-12 Monocyte count; LUSC trans rs156299 0.563 rs198304 chr7:24193423 G/A cg06529468 chr19:10676722 KRI1 0.38 6.2 0.32 1.7e-9 Vitamin D levels; LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.85 -0.3 1.19e-8 Platelet count; LUSC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg13298116 chr11:62369859 EML3;MTA2 0.59 9.56 0.46 2.74e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs9929218 0.748 rs34592833 chr16:68739125 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.87 -12.84 -0.57 6.19e-31 Colorectal cancer; LUSC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg18240062 chr17:79603768 NPLOC4 0.58 10.1 0.48 4.09e-21 Eye color traits; LUSC cis rs5769765 0.955 rs8139758 chr22:50261123 G/T cg26441486 chr22:50317300 CRELD2 -0.54 -8.25 -0.41 3.75e-15 Schizophrenia; LUSC cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg03233332 chr7:66118400 NA -0.42 -6.06 -0.31 3.63e-9 Aortic root size; LUSC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -10.69 -0.5 3.9699999999999997e-23 Schizophrenia; LUSC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg05535760 chr7:792225 HEATR2 -0.77 -7.64 -0.39 2.36e-13 Cerebrospinal P-tau181p levels; LUSC cis rs734999 0.505 rs4445406 chr1:2539400 T/C cg18932078 chr1:2524107 MMEL1 0.29 6.33 0.33 8.05e-10 Ulcerative colitis; LUSC cis rs17818399 0.926 rs13033177 chr2:46831062 C/A cg26688816 chr2:46740690 ATP6V1E2 -0.48 -6.28 -0.32 1.07e-9 Height; LUSC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg25282410 chr6:160211355 TCP1;MRPL18 1.11 16.95 0.68 6.38e-47 Age-related macular degeneration (geographic atrophy); LUSC cis rs12701220 0.596 rs10274383 chr7:1002013 T/C cg04102894 chr7:1000210 NA -0.28 -6.44 -0.33 4.07e-10 Bronchopulmonary dysplasia; LUSC cis rs3815700 1.000 rs10407204 chr19:33097353 C/T cg02997394 chr19:33096574 ANKRD27 0.83 9.48 0.46 4.88e-19 Eosinophilic esophagitis; LUSC cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg25456477 chr12:86230367 RASSF9 0.39 6.84 0.35 3.72e-11 Major depressive disorder; LUSC cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg23711669 chr6:146136114 FBXO30 0.75 13.4 0.59 4.72e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs10992471 0.603 rs10761155 chr9:95153729 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.55 -0.38 4.24e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2279817 0.735 rs11203432 chr1:17991196 A/G cg21791023 chr1:18019539 ARHGEF10L -0.45 -6.01 -0.31 4.88e-9 Neuroticism; LUSC cis rs6772849 0.896 rs4557179 chr3:128366726 A/C cg16766828 chr3:128327626 NA -0.3 -5.64 -0.3 3.56e-8 Monocyte percentage of white cells;Monocyte count; LUSC cis rs7246967 0.551 rs8103204 chr19:22936517 T/A cg23217946 chr19:22817039 ZNF492 0.43 5.87 0.31 1.04e-8 Bronchopulmonary dysplasia; LUSC cis rs7795096 0.806 rs10261999 chr7:151540659 G/T cg17008978 chr7:151542804 PRKAG2 0.35 6.63 0.34 1.34e-10 Bipolar disorder (age of onset and psychotic symptoms); LUSC cis rs6547741 0.874 rs28381983 chr2:27804432 T/C cg12559939 chr2:27858050 GPN1 0.41 6.34 0.33 7.57e-10 Oral cavity cancer; LUSC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.19 0.37 4.34e-12 Blood metabolite levels; LUSC cis rs8099014 1.000 rs4940392 chr18:56107146 G/A cg12907477 chr18:56117327 MIR122 0.41 6.54 0.34 2.25e-10 Platelet count; LUSC cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg00071950 chr4:10020882 SLC2A9 0.64 10.64 0.5 5.62e-23 Bone mineral density; LUSC cis rs3931020 0.688 rs968358 chr1:75193989 G/T cg00121533 chr1:75199117 CRYZ;TYW3 0.46 5.84 0.3 1.21e-8 Resistin levels; LUSC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15541040 chr2:3486749 NA -0.53 -8.42 -0.42 1.14e-15 Neurofibrillary tangles; LUSC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg07870213 chr5:140052090 DND1 0.78 11.53 0.53 4.14e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC trans rs7824557 0.614 rs2736286 chr8:11227104 A/G cg15556689 chr8:8085844 FLJ10661 -0.45 -6.97 -0.36 1.71e-11 Retinal vascular caliber; LUSC cis rs8017423 0.935 rs716122 chr14:90792313 A/C cg04374321 chr14:90722782 PSMC1 -0.66 -9.98 -0.48 1.04e-20 Mortality in heart failure; LUSC cis rs79839061 0.610 rs78590562 chr4:869715 C/T cg07828340 chr4:882639 GAK 1.07 11.34 0.53 1.99e-25 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg08470875 chr2:26401718 FAM59B -0.68 -9.16 -0.45 5.53e-18 Gut microbiome composition (summer); LUSC cis rs2795502 0.872 rs2744062 chr10:43254789 T/A cg20628663 chr10:43360327 NA -0.62 -7.81 -0.39 7.54e-14 Blood protein levels; LUSC cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg04455712 chr21:45112962 RRP1B 0.45 8.58 0.42 3.72e-16 Mean corpuscular volume; LUSC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg13393036 chr8:95962371 TP53INP1 -0.32 -6.18 -0.32 1.84e-9 Type 2 diabetes; LUSC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg22875332 chr1:76189707 ACADM -0.68 -9.42 -0.46 7.91e-19 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs61931739 1.000 rs11052967 chr12:34020030 T/G cg13010199 chr12:38710504 ALG10B -0.4 -6.11 -0.32 2.76e-9 Morning vs. evening chronotype; LUSC cis rs11229555 0.609 rs11229434 chr11:58185501 C/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg14196790 chr5:131705035 SLC22A5 0.48 8.06 0.4 1.34e-14 Blood metabolite levels; LUSC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.67 0.67 7.65e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs853679 0.607 rs13199906 chr6:27834139 C/G cg26958806 chr6:27640298 NA 0.83 6.57 0.34 1.94e-10 Depression; LUSC cis rs7677751 0.806 rs7681399 chr4:55090886 T/G cg17187183 chr4:55093834 PDGFRA 0.38 5.66 0.3 3.18e-8 Corneal astigmatism; LUSC cis rs9300255 0.620 rs1727311 chr12:123660716 T/G cg00376283 chr12:123451042 ABCB9 0.76 8.36 0.42 1.66e-15 Neutrophil percentage of white cells; LUSC cis rs9677476 0.779 rs10173555 chr2:232108769 C/G cg07929768 chr2:232055508 NA 0.37 6.21 0.32 1.59e-9 Food antigen IgG levels; LUSC cis rs17401966 0.800 rs12725210 chr1:10416993 G/A cg19773385 chr1:10388646 KIF1B -0.5 -8.72 -0.43 1.3e-16 Hepatocellular carcinoma; LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg09877947 chr5:131593287 PDLIM4 0.46 7.25 0.37 2.92e-12 Breast cancer; LUSC cis rs9653442 0.564 rs2309753 chr2:100775920 C/A cg07810366 chr2:100720526 AFF3 -0.44 -7.6 -0.38 2.92e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs506338 0.517 rs12269736 chr11:64471986 T/C cg19131476 chr11:64387923 NRXN2 0.36 7.82 0.39 7.2e-14 Body mass index;Urate levels; LUSC cis rs282587 0.569 rs282595 chr13:113379930 A/G cg07026882 chr13:113417167 ATP11A 0.49 5.73 0.3 2.26e-8 Glycated hemoglobin levels; LUSC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg09267113 chr7:98030324 BAIAP2L1 0.39 5.96 0.31 6.4e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs858239 0.730 rs858290 chr7:23248036 A/G cg05407003 chr7:23246146 NA -0.38 -5.74 -0.3 2.1e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs11030122 0.702 rs2898947 chr11:3977572 G/A cg08557956 chr11:4115526 RRM1 -0.45 -5.69 -0.3 2.81e-8 Mean platelet volume;Platelet distribution width; LUSC trans rs7939886 0.920 rs17150095 chr11:55902900 A/G cg15704280 chr7:45808275 SEPT13 0.83 6.64 0.34 1.27e-10 Myopia (pathological); LUSC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.31 -0.53 2.44e-25 Alzheimer's disease; LUSC cis rs6840360 0.571 rs4696101 chr4:152528513 A/G cg22705602 chr4:152727874 NA -0.33 -6.6 -0.34 1.66e-10 Intelligence (multi-trait analysis); LUSC cis rs8017423 0.967 rs17188605 chr14:90722579 C/T cg04374321 chr14:90722782 PSMC1 0.75 12.08 0.55 4e-28 Mortality in heart failure; LUSC cis rs2072499 0.833 rs2842870 chr1:156200671 T/C cg25208724 chr1:156163844 SLC25A44 1.04 21.93 0.77 1.19e-66 Testicular germ cell tumor; LUSC cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg01017244 chr2:74357527 NA 0.69 13.33 0.59 8.43e-33 Gestational age at birth (maternal effect); LUSC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg03676636 chr4:99064102 C4orf37 0.32 7.05 0.36 1.06e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs244731 0.959 rs10037110 chr5:176658066 A/T cg16006841 chr5:176797999 RGS14 -0.67 -9.33 -0.45 1.46e-18 Urate levels in lean individuals; LUSC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg23758822 chr17:41437982 NA 1.04 20.04 0.74 3.32e-59 Menopause (age at onset); LUSC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg16339924 chr4:17578868 LAP3 0.55 8.26 0.41 3.39e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg00530320 chr1:46809349 NSUN4 0.57 8.71 0.43 1.43e-16 Menopause (age at onset); LUSC trans rs4332037 0.539 rs56305291 chr7:2048706 A/G cg10840412 chr1:235813424 GNG4 0.56 7.28 0.37 2.36e-12 Bipolar disorder; LUSC cis rs6906287 0.625 rs7764272 chr6:118692498 A/C cg21191810 chr6:118973309 C6orf204 0.38 6.75 0.35 6.4e-11 Electrocardiographic conduction measures; LUSC cis rs61931739 0.534 rs4931770 chr12:34044479 G/T cg06521331 chr12:34319734 NA -0.48 -7.71 -0.39 1.43e-13 Morning vs. evening chronotype; LUSC cis rs1853665 0.721 rs62441761 chr6:150268065 A/G cg04697775 chr6:150285333 ULBP1 0.56 5.93 0.31 7.43e-9 Radiation response; LUSC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg24110177 chr3:50126178 RBM5 0.57 9.39 0.46 9.37e-19 Intelligence (multi-trait analysis); LUSC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg14668632 chr7:2872130 GNA12 -0.45 -6.81 -0.35 4.55e-11 Height; LUSC cis rs4474465 0.790 rs10793325 chr11:78252575 T/C cg27205649 chr11:78285834 NARS2 0.53 6.46 0.33 3.72e-10 Alzheimer's disease (survival time); LUSC cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg24642439 chr20:33292090 TP53INP2 0.64 9.98 0.48 1.09e-20 Coronary artery disease; LUSC trans rs11700980 0.551 rs2832020 chr21:30112231 G/A cg14791747 chr16:20752902 THUMPD1 0.56 6.14 0.32 2.31e-9 QRS complex (12-leadsum); LUSC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg08677398 chr8:58056175 NA 0.51 6.75 0.35 6.43e-11 Developmental language disorder (linguistic errors); LUSC cis rs5769707 0.521 rs6009805 chr22:50058715 T/C cg20744362 chr22:50050164 C22orf34 0.36 6.66 0.34 1.1e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg05347473 chr6:146136440 FBXO30 0.57 9.97 0.48 1.14e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs13064411 0.696 rs6798938 chr3:113218206 C/T cg18753928 chr3:113234510 CCDC52 -0.5 -7.61 -0.38 2.91e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg24838063 chr12:130822603 PIWIL1 0.71 11.02 0.52 2.72e-24 Menopause (age at onset); LUSC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg06112835 chr11:68658793 MRPL21 0.51 7.88 0.4 4.58e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.74 -0.51 2.59e-23 Chronic sinus infection; LUSC cis rs1348850 0.958 rs4893965 chr2:178463852 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 5.96 0.31 6.38e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg13531842 chr10:38383804 ZNF37A -0.46 -7.23 -0.37 3.4e-12 Extrinsic epigenetic age acceleration; LUSC cis rs694739 0.628 rs508168 chr11:64135435 G/A cg02228329 chr11:64053129 BAD;GPR137 0.43 6.07 0.32 3.4e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7264396 1.000 rs6088881 chr20:34165609 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.52 7.77 0.39 9.46e-14 Total cholesterol levels; LUSC cis rs7923609 0.934 rs10761756 chr10:65172328 C/T cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg27494647 chr7:150038898 RARRES2 0.45 6.84 0.35 3.69e-11 Blood protein levels;Circulating chemerin levels; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg08333703 chr19:35225315 ZNF181 0.31 5.95 0.31 6.7e-9 Metabolite levels (Pyroglutamine); LUSC cis rs10788264 0.504 rs7069328 chr10:124030741 G/C cg09507567 chr10:124027408 NA 0.55 9.87 0.48 2.53e-20 Total body bone mineral density; LUSC trans rs4938303 0.587 rs10892017 chr11:116567881 G/C cg12339133 chr7:1031174 NA -0.32 -5.98 -0.31 5.64e-9 Triglycerides; LUSC cis rs7954584 0.604 rs34159444 chr12:122416667 A/G cg10207240 chr12:122356781 WDR66 0.46 6.57 0.34 1.96e-10 Mean corpuscular volume; LUSC cis rs2439831 0.850 rs60883262 chr15:44076503 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.74 6.97 0.36 1.75e-11 Lung cancer in ever smokers; LUSC trans rs617791 0.530 rs10791835 chr11:65750924 C/A cg17712092 chr4:129076599 LARP1B -0.73 -10.24 -0.49 1.38e-21 Breast cancer; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 13.5 0.59 1.9e-33 Alzheimer's disease; LUSC cis rs1595825 0.891 rs78835808 chr2:198669110 G/A cg10547527 chr2:198650123 BOLL -0.5 -5.71 -0.3 2.49e-8 Ulcerative colitis; LUSC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.42 -0.33 4.81e-10 Total body bone mineral density; LUSC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg17507749 chr15:85114479 UBE2QP1 0.68 8.55 0.42 4.36e-16 Schizophrenia; LUSC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg22535103 chr8:58192502 C8orf71 -0.81 -9.85 -0.47 3e-20 Developmental language disorder (linguistic errors); LUSC trans rs724744 0.710 rs1737235 chr6:22351177 C/T cg13807341 chr11:118445984 ARCN1 -0.36 -6.18 -0.32 1.89e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs7512552 0.839 rs12046446 chr1:150460855 T/G cg15654264 chr1:150340011 RPRD2 0.63 10.31 0.49 8.08e-22 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs61931739 0.534 rs2389276 chr12:34097891 T/C cg06521331 chr12:34319734 NA -0.52 -8.62 -0.43 2.69e-16 Morning vs. evening chronotype; LUSC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg25258033 chr6:167368657 RNASET2 0.46 7.67 0.39 1.91e-13 Crohn's disease; LUSC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg18240062 chr17:79603768 NPLOC4 -0.8 -15.5 -0.65 3.45e-41 Eye color traits; LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.33 0.53 2.21e-25 Menopause (age at onset); LUSC cis rs193541 0.626 rs6898725 chr5:122086938 G/A cg19077854 chr5:122220652 SNX24 0.27 6.16 0.32 2.12e-9 Glucose homeostasis traits; LUSC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg23891399 chr17:73824620 UNC13D 0.35 5.68 0.3 2.89e-8 White matter hyperintensity burden; LUSC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg16447950 chr5:562315 NA -0.53 -6.97 -0.36 1.69e-11 Obesity-related traits; LUSC cis rs6429082 0.744 rs903347 chr1:235586613 C/T cg26050004 chr1:235667680 B3GALNT2 -0.56 -7.94 -0.4 3.11e-14 Adiposity; LUSC trans rs61931739 0.824 rs406753 chr12:34117408 A/G cg26384229 chr12:38710491 ALG10B 0.56 9.0 0.44 1.77e-17 Morning vs. evening chronotype; LUSC cis rs6977660 0.714 rs10276518 chr7:19781325 C/A cg07541023 chr7:19748670 TWISTNB 0.68 6.79 0.35 5.11e-11 Thyroid stimulating hormone; LUSC trans rs1814175 0.817 rs7947526 chr11:49983654 T/C cg03929089 chr4:120376271 NA -1.04 -20.22 -0.74 5.96e-60 Height; LUSC cis rs500891 0.768 rs17255340 chr6:84089191 G/A cg08257003 chr6:84140564 ME1 0.33 6.91 0.35 2.5e-11 Platelet-derived growth factor BB levels; LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg03188948 chr7:1209495 NA 0.66 6.93 0.35 2.24e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg21770322 chr7:97807741 LMTK2 0.41 7.05 0.36 1.04e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs10754283 0.967 rs2002883 chr1:90105838 A/G cg21401794 chr1:90099060 LRRC8C 0.65 9.74 0.47 6.91e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg07701084 chr6:150067640 NUP43 0.56 8.54 0.42 4.82e-16 Lung cancer; LUSC cis rs6977660 0.714 rs4719587 chr7:19828174 C/G cg07541023 chr7:19748670 TWISTNB 0.57 6.18 0.32 1.87e-9 Thyroid stimulating hormone; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg16335926 chr5:142784462 NR3C1 0.41 6.28 0.32 1.06e-9 Schizophrenia; LUSC trans rs853679 0.607 rs13216117 chr6:27938484 A/G cg01620082 chr3:125678407 NA -0.8 -7.24 -0.37 3.11e-12 Depression; LUSC cis rs6681460 0.932 rs2483705 chr1:67191180 C/G cg02459107 chr1:67143332 SGIP1 -0.47 -8.71 -0.43 1.46e-16 Presence of antiphospholipid antibodies; LUSC cis rs7168353 1.000 rs7168353 chr15:93638401 C/G cg02918577 chr15:93633145 RGMA 0.46 7.75 0.39 1.11e-13 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy); LUSC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.27 -0.32 1.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -8.39 -0.42 1.41e-15 Schizophrenia; LUSC cis rs2486288 0.656 rs2413774 chr15:45549423 C/T cg09092052 chr15:45571596 NA 0.45 6.31 0.33 8.87e-10 Glomerular filtration rate; LUSC cis rs2658782 0.901 rs11604909 chr11:93218355 C/G cg15737290 chr11:93063684 CCDC67 0.63 7.53 0.38 4.63e-13 Pulmonary function decline; LUSC trans rs34816374 1 rs34816374 chr6:26949672 A/G cg06606381 chr12:133084897 FBRSL1 -0.9 -8.31 -0.41 2.38e-15 Lung cancer in ever smokers; LUSC cis rs4629710 0.592 rs9492865 chr6:131534403 T/A cg12700074 chr6:131571435 AKAP7 -0.37 -6.22 -0.32 1.48e-9 Multiple myeloma (IgH translocation); LUSC cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg24692254 chr21:30365293 RNF160 0.83 15.57 0.65 1.71e-41 Dental caries; LUSC cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg05738196 chr6:26577821 NA -0.83 -16.04 -0.66 2.51e-43 Intelligence (multi-trait analysis); LUSC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg00745463 chr17:30367425 LRRC37B -0.79 -9.21 -0.45 3.75e-18 Hip circumference adjusted for BMI; LUSC cis rs12908161 0.959 rs12908699 chr15:85240403 G/T cg11189052 chr15:85197271 WDR73 0.48 5.93 0.31 7.56e-9 Schizophrenia; LUSC cis rs10740039 0.516 rs1348281 chr10:62356233 C/T cg18175470 chr10:62150864 ANK3 0.47 7.27 0.37 2.5e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11098499 0.955 rs13114751 chr4:120156617 G/A cg24375607 chr4:120327624 NA 0.75 11.42 0.53 9.94e-26 Corneal astigmatism; LUSC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg03351412 chr1:154909251 PMVK 0.51 7.98 0.4 2.45e-14 Prostate cancer; LUSC cis rs6696846 0.749 rs7515178 chr1:205084120 G/A cg21545522 chr1:205238299 TMCC2 0.42 8.08 0.4 1.18e-14 Red blood cell count; LUSC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg26380479 chr7:97908229 NA -0.27 -6.06 -0.31 3.67e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12681288 0.523 rs112307130 chr8:962483 G/A cg15309053 chr8:964076 NA 0.41 8.19 0.41 5.46e-15 Schizophrenia; LUSC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg24549020 chr5:56110836 MAP3K1 0.49 5.98 0.31 5.58e-9 Initial pursuit acceleration; LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 6.36 0.33 6.55e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4253772 0.938 rs41329344 chr22:46636930 C/T cg18190219 chr22:46762943 CELSR1 -0.51 -5.92 -0.31 7.92e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs10886558 0.502 rs4428989 chr10:121825969 G/A cg02041677 chr10:121771263 NA -0.33 -6.02 -0.31 4.7e-9 Shingles; LUSC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg05552183 chr6:42928497 GNMT 0.52 8.67 0.43 1.9e-16 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs12421382 0.659 rs11604254 chr11:109392413 G/A cg27471124 chr11:109292789 C11orf87 0.43 7.46 0.38 7.48e-13 Schizophrenia; LUSC cis rs735396 0.770 rs2259820 chr12:121435342 C/T cg25281562 chr12:121454272 C12orf43 0.46 5.86 0.31 1.12e-8 N-glycan levels; LUSC trans rs877282 0.898 rs11253349 chr10:765897 C/G cg13042288 chr15:90349979 ANPEP -0.47 -6.41 -0.33 4.97e-10 Uric acid levels; LUSC trans rs3857536 0.776 rs2040593 chr6:66944076 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.04 -0.31 4.02e-9 Blood trace element (Cu levels); LUSC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg17747265 chr1:1875780 NA 0.64 13.68 0.6 3.81e-34 Body mass index; LUSC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg22823121 chr1:150693482 HORMAD1 0.57 8.78 0.43 8.37e-17 Tonsillectomy; LUSC cis rs2219968 0.962 rs7828745 chr8:78947372 G/A cg00738934 chr8:78996279 NA 0.37 6.58 0.34 1.77e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.48 0.38 6.51e-13 Bipolar disorder; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg25593729 chr12:122150344 TMEM120B 0.59 7.27 0.37 2.65e-12 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02801482 chr2:159824941 TANC1 -0.42 -6.48 -0.33 3.39e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg03647239 chr10:116582469 FAM160B1 0.47 7.58 0.38 3.42e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs8078723 0.690 rs56326707 chr17:38130139 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.53 -8.92 -0.44 3.2e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg22875332 chr1:76189707 ACADM 0.76 12.03 0.55 6.02e-28 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4654899 0.965 rs2873424 chr1:21500701 C/A cg01072550 chr1:21505969 NA -0.53 -8.11 -0.41 9.91e-15 Superior frontal gyrus grey matter volume; LUSC cis rs7177699 0.526 rs7182529 chr15:79123631 T/C cg00540400 chr15:79124168 NA 0.43 7.51 0.38 5.44e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg14438399 chr17:27053147 TLCD1 0.52 5.75 0.3 2.05e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs1712517 0.771 rs61350103 chr10:105069120 A/C cg05636881 chr10:105038444 INA 0.39 6.39 0.33 5.66e-10 Migraine; LUSC cis rs41271473 1.000 rs11587994 chr1:228860072 A/C cg10167378 chr1:228756711 NA 0.61 7.28 0.37 2.48e-12 Chronic lymphocytic leukemia; LUSC cis rs3540 0.553 rs2158406 chr15:90994499 T/C cg22089800 chr15:90895588 ZNF774 0.63 9.5 0.46 4.11e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg01765077 chr12:122356316 WDR66 0.55 8.1 0.41 1.04e-14 Mean platelet volume; LUSC cis rs6741892 0.511 rs35585199 chr2:38923722 C/T cg23643435 chr2:38893251 GALM -0.72 -5.7 -0.3 2.6e-8 5-HTT brain serotonin transporter levels; LUSC cis rs7615952 1.000 rs7616044 chr3:125649354 G/C cg05084668 chr3:125655381 ALG1L -0.78 -11.67 -0.54 1.31e-26 Blood pressure (smoking interaction); LUSC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg17366294 chr4:99064904 C4orf37 0.59 10.37 0.49 5.04e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg06634786 chr22:41940651 POLR3H -0.53 -6.06 -0.31 3.76e-9 Vitiligo; LUSC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg14061069 chr19:46274453 DMPK -0.51 -8.65 -0.43 2.17e-16 Coronary artery disease; LUSC cis rs4690686 0.500 rs11728314 chr4:177268373 G/A cg17059388 chr4:177262070 NA 0.46 8.63 0.43 2.62e-16 Essential tremor; LUSC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg25258033 chr6:167368657 RNASET2 -0.49 -8.12 -0.41 9.03e-15 Crohn's disease; LUSC cis rs13256369 0.802 rs13280101 chr8:8562773 G/A cg00074818 chr8:8560427 CLDN23 0.59 9.8 0.47 4.21e-20 Obesity-related traits; LUSC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg18357526 chr6:26021779 HIST1H4A 0.45 7.22 0.37 3.63e-12 Intelligence (multi-trait analysis); LUSC trans rs7681440 0.874 rs7687945 chr4:90764699 C/T cg02113368 chr10:135107346 TUBGCP2 -0.34 -6.01 -0.31 4.92e-9 Dementia with Lewy bodies; LUSC cis rs9653442 0.777 rs6732141 chr2:100743492 G/C cg22139774 chr2:100720529 AFF3 -0.53 -9.61 -0.47 1.76e-19 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC trans rs6851442 0.614 rs28374811 chr4:109038758 G/A cg24541021 chr2:218896725 NA 0.42 5.95 0.31 6.73e-9 Amyotrophic lateral sclerosis (sporadic); LUSC trans rs1814175 0.653 rs10839480 chr11:50034556 C/T cg15704280 chr7:45808275 SEPT13 -1.11 -24.79 -0.8 1.03e-77 Height; LUSC cis rs9467773 0.933 rs35355150 chr6:26526039 G/A cg05738196 chr6:26577821 NA 0.8 15.43 0.65 6.24e-41 Intelligence (multi-trait analysis); LUSC cis rs911119 0.954 rs2424582 chr20:23622550 A/G cg16589663 chr20:23618590 CST3 0.6 7.51 0.38 5.38e-13 Chronic kidney disease; LUSC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg02038168 chr22:39784481 NA -0.5 -8.31 -0.41 2.45e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs11971779 0.666 rs6467847 chr7:139079436 T/C cg07862535 chr7:139043722 LUC7L2 0.64 7.81 0.39 7.53e-14 Diisocyanate-induced asthma; LUSC cis rs7605827 0.866 rs6745922 chr2:15537931 G/C cg19274914 chr2:15703543 NA 0.46 8.98 0.44 2e-17 Educational attainment (years of education); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13692001 chr19:40023494 EID2B 0.83 7.18 0.37 4.6e-12 Cognitive performance; LUSC cis rs8064299 0.934 rs895692 chr17:72766252 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.64 10.86 0.51 9.78e-24 Monocyte count; LUSC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg16624210 chr5:671434 TPPP 0.47 5.92 0.31 8.21e-9 Lung disease severity in cystic fibrosis; LUSC cis rs4319547 0.656 rs9788145 chr12:122899522 C/T cg05707623 chr12:122985044 ZCCHC8 -0.67 -8.33 -0.41 2.12e-15 Body mass index; LUSC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg12963246 chr6:28129442 ZNF389 0.43 6.0 0.31 5.17e-9 Depression; LUSC trans rs7529925 0.739 rs12239179 chr1:198976492 C/T cg25702651 chr3:192675515 NA -0.35 -6.0 -0.31 5.28e-9 Mean corpuscular volume;Red blood cell traits; LUSC cis rs12586317 0.620 rs7147571 chr14:35530236 T/C cg05294307 chr14:35346193 BAZ1A -0.58 -6.99 -0.36 1.51e-11 Psoriasis; LUSC cis rs11077998 0.967 rs11657886 chr17:80516173 T/C cg10255544 chr17:80519551 FOXK2 0.38 6.24 0.32 1.36e-9 Reticulocyte fraction of red cells; LUSC cis rs6964587 1.000 rs2301559 chr7:91746727 T/C cg22117172 chr7:91764530 CYP51A1 0.33 5.83 0.3 1.34e-8 Breast cancer; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.02 -0.4 1.83e-14 Lymphocyte counts; LUSC cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.35 -0.46 1.28e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs7647973 0.626 rs9870858 chr3:49769071 C/T cg21659725 chr3:3221576 CRBN -0.66 -8.04 -0.4 1.57e-14 Menarche (age at onset); LUSC cis rs1971762 0.561 rs4759288 chr12:54084006 T/A cg23533419 chr12:54090519 NA -0.36 -6.04 -0.31 4.21e-9 Height; LUSC cis rs12368653 0.545 rs2277324 chr12:58013175 G/A cg12615879 chr12:58013172 SLC26A10 0.45 10.69 0.5 3.86e-23 Multiple sclerosis; LUSC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs7481584 0.624 rs412842 chr11:3047448 A/G cg25174290 chr11:3078921 CARS -0.41 -6.18 -0.32 1.87e-9 Calcium levels; LUSC cis rs1371867 0.817 rs1788208 chr8:101312515 T/C cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.35e-15 Atrioventricular conduction; LUSC cis rs796364 0.715 rs11688872 chr2:201052418 C/T cg23649088 chr2:200775458 C2orf69 -0.56 -6.7 -0.34 8.65e-11 Schizophrenia; LUSC cis rs3806843 1.000 rs6891995 chr5:140172008 A/G cg19875535 chr5:140030758 IK 0.5 8.28 0.41 3.06e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs7833986 0.501 rs2953922 chr8:56977485 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.74 12.46 0.56 1.61e-29 Height; LUSC trans rs7739264 0.564 rs760796 chr6:19790387 C/T cg13431028 chr2:169073609 STK39 0.36 6.05 0.31 3.85e-9 Endometriosis; LUSC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg07701084 chr6:150067640 NUP43 0.5 7.43 0.38 8.98e-13 Lung cancer; LUSC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg04850211 chr1:228464232 OBSCN -0.33 -6.17 -0.32 2.03e-9 Diastolic blood pressure; LUSC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg05585544 chr11:47624801 NA -0.42 -7.31 -0.37 2.04e-12 Subjective well-being; LUSC cis rs10876993 0.890 rs810204 chr12:58075733 T/C cg18357645 chr12:58087776 OS9 0.55 8.21 0.41 4.97e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs7615952 0.932 rs13314869 chr3:125644669 G/A cg05084668 chr3:125655381 ALG1L -0.77 -11.54 -0.53 3.85e-26 Blood pressure (smoking interaction); LUSC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg25282410 chr6:160211355 TCP1;MRPL18 1.13 17.23 0.69 4.9e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs10761482 1.000 rs10821722 chr10:62081085 A/G cg18175470 chr10:62150864 ANK3 -0.48 -6.74 -0.35 7.11e-11 Schizophrenia; LUSC cis rs7586879 0.558 rs6718510 chr2:25122323 A/C cg04586622 chr2:25135609 ADCY3 0.42 8.97 0.44 2.22e-17 Body mass index; LUSC cis rs7267979 1.000 rs4815406 chr20:25341316 C/G cg08601574 chr20:25228251 PYGB -0.42 -6.43 -0.33 4.39e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg23711669 chr6:146136114 FBXO30 -0.82 -14.78 -0.63 2.13e-38 Lobe attachment (rater-scored or self-reported); LUSC cis rs4478858 0.735 rs11436 chr1:31837320 T/C cg00250761 chr1:31883323 NA -0.36 -8.66 -0.43 1.99e-16 Alcohol dependence; LUSC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.84 -0.57 5.91e-31 Alzheimer's disease; LUSC cis rs6714710 0.603 rs11690687 chr2:98461821 C/T cg26665480 chr2:98280029 ACTR1B 0.56 8.14 0.41 7.74e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs35952432 1 rs35952432 chr6:28074901 C/T cg01620082 chr3:125678407 NA -0.85 -7.28 -0.37 2.42e-12 Lung cancer; LUSC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.21 0.61 3.68e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs56283067 0.847 rs12208621 chr6:44752003 G/C cg20913747 chr6:44695427 NA -0.5 -8.36 -0.42 1.71e-15 Total body bone mineral density; LUSC trans rs9341835 0.510 rs2622284 chr6:64193572 T/C cg19533977 chr17:57719682 CLTC 0.33 6.11 0.32 2.8e-9 Schizophrenia; LUSC cis rs7799006 0.582 rs7781284 chr7:2339405 G/T cg12823233 chr7:2316876 SNX8 -0.35 -5.86 -0.31 1.11e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.62 0.47 1.66e-19 Bipolar disorder; LUSC cis rs920590 0.510 rs4922101 chr8:19648895 A/G cg01411142 chr8:19674711 INTS10 0.5 5.66 0.3 3.31e-8 Acute lymphoblastic leukemia (childhood); LUSC cis rs950027 0.596 rs2467865 chr15:45638307 T/C cg14582100 chr15:45693742 SPATA5L1 0.44 8.43 0.42 1.07e-15 Response to fenofibrate (adiponectin levels); LUSC cis rs75920871 0.528 rs7109649 chr11:116943544 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.48 -0.33 3.25e-10 Subjective well-being; LUSC cis rs9948 0.655 rs61742095 chr2:97366088 T/C cg01990225 chr2:97406019 LMAN2L -1.02 -7.2 -0.37 4.01e-12 Erectile dysfunction and prostate cancer treatment; LUSC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.24 0.41 3.98e-15 Age-related macular degeneration (geographic atrophy); LUSC cis rs2637266 1.000 rs11001835 chr10:78364770 A/G cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.61e-12 Pulmonary function; LUSC cis rs41271473 0.526 rs942852 chr1:228730748 A/G cg16512390 chr1:228756714 NA 0.7 8.89 0.44 4.03e-17 Chronic lymphocytic leukemia; LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.68 0.34 9.71e-11 Menopause (age at onset); LUSC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg05855489 chr10:104503620 C10orf26 -0.71 -10.0 -0.48 8.76e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.11 -0.45 7.95e-18 Monocyte percentage of white cells; LUSC cis rs17826219 0.706 rs28469200 chr17:29133572 T/A cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.64e-11 Body mass index; LUSC trans rs10506458 0.915 rs2013050 chr12:63394310 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -15.09 -0.64 1.37e-39 Hemostatic factors and hematological phenotypes; LUSC cis rs2282032 0.527 rs8020828 chr14:90768183 C/T cg14092571 chr14:90743983 NA 0.48 8.03 0.4 1.67e-14 Longevity; LUSC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg22467129 chr15:76604101 ETFA 0.43 6.94 0.35 2.07e-11 Blood metabolite levels; LUSC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg17968037 chr7:100024898 ZCWPW1 -0.43 -6.22 -0.32 1.48e-9 Platelet count; LUSC cis rs7607369 0.572 rs629177 chr2:219454801 T/G cg02176678 chr2:219576539 TTLL4 0.75 14.7 0.63 4.6e-38 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs10927875 1.000 rs12138117 chr1:16305279 T/C cg22431228 chr1:16359049 CLCNKA 0.44 8.53 0.42 5.02e-16 Dilated cardiomyopathy; LUSC cis rs9378688 0.654 rs2479008 chr6:2347808 C/T cg12303981 chr6:2244766 GMDS -0.4 -5.72 -0.3 2.38e-8 Caudate nucleus volume; LUSC trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg15704280 chr7:45808275 SEPT13 -0.84 -11.72 -0.54 8.17e-27 Coronary artery disease; LUSC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.35 0.53 1.87e-25 Menopause (age at onset); LUSC cis rs7923609 0.967 rs10761752 chr10:65160321 T/C cg01631684 chr10:65280961 REEP3 -0.42 -6.45 -0.33 4.01e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs3806843 1.000 rs1030165 chr5:140185448 G/A cg26395211 chr5:140044315 WDR55 -0.38 -5.74 -0.3 2.14e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9311676 0.632 rs56288363 chr3:58374533 A/T cg13750441 chr3:58318267 PXK 0.36 6.89 0.35 2.78e-11 Systemic lupus erythematosus; LUSC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg16405210 chr4:1374714 KIAA1530 -0.85 -13.81 -0.6 1.26e-34 Longevity; LUSC cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg06064525 chr11:970664 AP2A2 -0.49 -10.7 -0.51 3.73e-23 Alzheimer's disease (late onset); LUSC cis rs6964587 1.000 rs56072181 chr7:91690457 A/G cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg15704280 chr7:45808275 SEPT13 -1.03 -19.25 -0.73 4.28e-56 Height; LUSC cis rs6500395 0.962 rs9941275 chr16:48573428 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.57 0.34 1.93e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2004776 0.656 rs11122586 chr1:230866121 G/A cg07502417 chr1:230849801 AGT 0.25 5.74 0.3 2.12e-8 Diastolic blood pressure; LUSC trans rs35110281 0.667 rs7282405 chr21:45123611 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.64 10.57 0.5 9.93e-23 Mean corpuscular volume; LUSC cis rs7923609 0.902 rs4633333 chr10:65328539 C/G cg01631684 chr10:65280961 REEP3 -0.42 -6.59 -0.34 1.77e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs72781680 0.898 rs72780121 chr2:23995918 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg10624161 chr6:107349251 C6orf203 -0.56 -6.99 -0.36 1.48e-11 Bipolar disorder and schizophrenia; LUSC trans rs7951105 1.000 rs12282788 chr11:39258863 T/A cg24085930 chr3:21832523 NA 0.48 6.02 0.31 4.72e-9 Free thyroxine concentration; LUSC cis rs1577917 0.665 rs4304137 chr6:86217448 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.49 0.42 6.73e-16 Response to antipsychotic treatment; LUSC cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg05802129 chr4:122689817 NA -0.46 -7.79 -0.39 8.32e-14 Type 2 diabetes; LUSC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg03433033 chr1:76189801 ACADM 0.84 15.34 0.64 1.48e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6121246 0.609 rs6060627 chr20:30262159 C/T cg21427119 chr20:30132790 HM13 -0.35 -5.67 -0.3 3.08e-8 Mean corpuscular hemoglobin; LUSC cis rs3617 0.573 rs4687682 chr3:52916939 T/C cg11645453 chr3:52864694 ITIH4 -0.4 -9.2 -0.45 4.07e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs62244186 0.545 rs9284880 chr3:44759389 C/T cg02073558 chr3:44770973 ZNF501 0.59 9.78 0.47 4.98e-20 Depressive symptoms; LUSC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg16606324 chr3:10149918 C3orf24 0.63 8.77 0.43 8.98e-17 Alzheimer's disease; LUSC cis rs4853012 0.887 rs7570950 chr2:74338942 T/C cg01017244 chr2:74357527 NA 0.65 11.56 0.53 3.04e-26 Gestational age at birth (maternal effect); LUSC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg04944784 chr2:26401820 FAM59B -0.7 -9.79 -0.47 4.69e-20 Gut microbiome composition (summer); LUSC cis rs1881396 0.531 rs4665385 chr2:27930837 C/T cg27432699 chr2:27873401 GPN1 0.63 7.72 0.39 1.34e-13 Nonalcoholic fatty liver disease; LUSC trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC trans rs1927790 0.727 rs12583988 chr13:96991602 G/A cg03198741 chr6:1003969 LOC285768 -0.4 -5.99 -0.31 5.57e-9 Body mass index; LUSC cis rs6500395 1.000 rs8052073 chr16:48682696 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.8 0.35 4.69e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4794106 0.792 rs847682 chr17:48208274 C/T cg13893634 chr17:48229117 PPP1R9B -0.5 -7.72 -0.39 1.34e-13 Temporomandibular joint disorder; LUSC cis rs7833986 0.501 rs2953911 chr8:56948009 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.72 12.0 0.55 8.08e-28 Height; LUSC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg19678392 chr7:94953810 PON1 -0.38 -6.12 -0.32 2.65e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg05025164 chr4:1340916 KIAA1530 0.41 6.12 0.32 2.59e-9 Obesity-related traits; LUSC cis rs11608355 0.508 rs2075434 chr12:109797051 G/A cg19025524 chr12:109796872 NA -0.47 -8.43 -0.42 1.02e-15 Neuroticism; LUSC cis rs10191773 0.535 rs11685514 chr2:113100014 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.65 -8.03 -0.4 1.69e-14 Yeast infection; LUSC cis rs7647973 1.000 rs892974 chr3:49398514 C/A cg07636037 chr3:49044803 WDR6 0.67 8.65 0.43 2.22e-16 Menarche (age at onset); LUSC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg26441486 chr22:50317300 CRELD2 0.49 7.28 0.37 2.45e-12 Schizophrenia; LUSC cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg22709100 chr7:91322751 NA -0.41 -6.04 -0.31 4.17e-9 Breast cancer; LUSC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg23625390 chr15:77176239 SCAPER 0.45 6.9 0.35 2.55e-11 Blood metabolite levels; LUSC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg23711669 chr6:146136114 FBXO30 -0.89 -17.27 -0.69 3.42e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs9807989 0.811 rs11688568 chr2:102969949 C/T cg03938978 chr2:103052716 IL18RAP 0.31 5.79 0.3 1.58e-8 Asthma; LUSC cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg06784218 chr1:46089804 CCDC17 -0.57 -11.51 -0.53 4.96e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7618501 0.633 rs3774733 chr3:50037123 C/G cg21659725 chr3:3221576 CRBN 0.63 10.43 0.5 3.02e-22 Intelligence (multi-trait analysis); LUSC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg22963979 chr7:1858916 MAD1L1 -0.59 -9.03 -0.44 1.38e-17 Bipolar disorder and schizophrenia; LUSC cis rs55986470 0.670 rs56313033 chr2:239346202 C/T cg18131467 chr2:239335373 ASB1 -0.74 -6.62 -0.34 1.45e-10 Chronotype; LUSC cis rs6430585 0.528 rs7606267 chr2:136668123 T/C cg07169764 chr2:136633963 MCM6 1.15 18.46 0.71 6.19e-53 Corneal structure; LUSC trans rs8072100 0.811 rs1912483 chr17:45443494 A/G cg03886242 chr7:26192032 NFE2L3 -0.4 -6.47 -0.33 3.54e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6580649 1.000 rs6580649 chr12:48410517 A/G cg24011408 chr12:48396354 COL2A1 0.57 7.36 0.37 1.46e-12 Lung cancer; LUSC cis rs7428496 0.528 rs13063075 chr3:142263372 G/A cg16271453 chr3:142027066 XRN1 -0.5 -8.65 -0.43 2.13e-16 Mean corpuscular hemoglobin; LUSC cis rs7712401 0.601 rs30022 chr5:122285716 T/A cg19077854 chr5:122220652 SNX24 0.44 9.86 0.47 2.76e-20 Mean platelet volume; LUSC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg03570417 chr12:132312461 MMP17 0.43 7.61 0.38 2.85e-13 Migraine; LUSC trans rs9747201 1.000 rs9747668 chr17:80161081 A/G cg07393940 chr7:158741817 NA 0.52 8.6 0.43 3.15e-16 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4629710 0.592 rs13205441 chr6:131575069 G/A cg12700074 chr6:131571435 AKAP7 -0.35 -5.9 -0.31 8.89e-9 Multiple myeloma (IgH translocation); LUSC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg03676636 chr4:99064102 C4orf37 0.35 7.56 0.38 3.82e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6429082 0.818 rs291340 chr1:235674379 C/T cg26050004 chr1:235667680 B3GALNT2 0.62 8.33 0.41 2.17e-15 Adiposity; LUSC cis rs7647973 0.626 rs4855849 chr3:49653378 A/G cg13072238 chr3:49761600 GMPPB -0.69 -9.06 -0.44 1.08e-17 Menarche (age at onset); LUSC trans rs12310956 0.510 rs7301767 chr12:33886529 A/T cg13010199 chr12:38710504 ALG10B 0.45 7.0 0.36 1.44e-11 Morning vs. evening chronotype; LUSC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -8.96 -0.44 2.37e-17 Gut microbiome composition (summer); LUSC cis rs11031096 0.738 rs2923950 chr11:4042069 G/C cg18678763 chr11:4115507 RRM1 0.39 5.81 0.3 1.47e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg23985595 chr17:80112537 CCDC57 0.33 6.33 0.33 7.82e-10 Life satisfaction; LUSC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg11812906 chr14:75593930 NEK9 -0.62 -10.39 -0.49 4.13e-22 Height; LUSC cis rs782590 0.967 rs17798852 chr2:55805172 A/C cg03859395 chr2:55845619 SMEK2 0.87 16.07 0.66 1.97e-43 Metabolic syndrome; LUSC trans rs7613875 0.537 rs6446195 chr3:50070853 A/G cg21659725 chr3:3221576 CRBN -0.53 -8.41 -0.42 1.23e-15 Body mass index; LUSC trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg15704280 chr7:45808275 SEPT13 -0.51 -7.26 -0.37 2.79e-12 HDL cholesterol; LUSC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg11812906 chr14:75593930 NEK9 -0.64 -10.48 -0.5 2.14e-22 Height; LUSC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 14.4 0.62 6.64e-37 Platelet count; LUSC cis rs7523050 0.643 rs67567504 chr1:109402580 C/A cg08274380 chr1:109419600 GPSM2 1.1 10.61 0.5 7.32e-23 Fat distribution (HIV); LUSC cis rs17433780 0.808 rs12125301 chr1:89508501 G/A cg09516651 chr1:89888402 LOC400759 0.61 11.67 0.54 1.25e-26 Carotid intima media thickness; LUSC cis rs7000551 0.653 rs4872504 chr8:22326717 A/G cg12081754 chr8:22256438 SLC39A14 0.48 7.25 0.37 2.98e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg13798780 chr7:105162888 PUS7 0.56 6.15 0.32 2.23e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9467773 0.844 rs2393669 chr6:26503873 C/T cg05738196 chr6:26577821 NA 0.81 15.2 0.64 4.95e-40 Intelligence (multi-trait analysis); LUSC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg11843238 chr5:131593191 PDLIM4 0.45 7.99 0.4 2.15e-14 Blood metabolite levels; LUSC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.1e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg06640241 chr16:89574553 SPG7 0.89 16.13 0.66 1.07e-43 Multiple myeloma (IgH translocation); LUSC trans rs1941687 0.524 rs6507062 chr18:31374197 G/C cg15819921 chr19:927150 ARID3A -0.43 -6.37 -0.33 6.25e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs1113500 0.897 rs2336127 chr1:108640870 G/A cg11967332 chr1:108735228 SLC25A24 0.4 6.07 0.32 3.49e-9 Growth-regulated protein alpha levels; LUSC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 5.78 0.3 1.76e-8 Personality dimensions; LUSC cis rs611744 0.647 rs1379336 chr8:109276606 G/T cg18478394 chr8:109455254 TTC35 0.43 6.79 0.35 5.26e-11 Dupuytren's disease; LUSC trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg08975724 chr8:8085496 FLJ10661 -0.42 -6.06 -0.31 3.6e-9 Systolic blood pressure; LUSC cis rs722599 0.715 rs11851433 chr14:75339450 C/T cg06637938 chr14:75390232 RPS6KL1 0.41 6.07 0.32 3.5e-9 IgG glycosylation; LUSC cis rs2637266 0.967 rs12246436 chr10:78352914 C/T cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg16060761 chr17:80687452 NA 0.41 6.31 0.33 8.74e-10 Breast cancer; LUSC cis rs11209185 0.672 rs1926278 chr1:68453859 C/T cg22082780 chr1:68452167 NA 0.33 6.26 0.32 1.22e-9 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs1801251 1.000 rs7578299 chr2:233573469 G/T cg25237894 chr2:233734115 C2orf82 0.35 6.41 0.33 4.96e-10 Coronary artery disease; LUSC cis rs3820928 0.874 rs13419455 chr2:227850465 C/G cg11843606 chr2:227700838 RHBDD1 -0.53 -7.63 -0.39 2.44e-13 Pulmonary function; LUSC cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg22676075 chr6:135203613 NA 0.59 9.41 0.46 8.46e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 8.19e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg04287289 chr16:89883240 FANCA 0.4 5.81 0.3 1.46e-8 Vitiligo; LUSC cis rs6500602 0.702 rs6500606 chr16:4502514 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.49 -6.53 -0.34 2.5e-10 Schizophrenia; LUSC cis rs11098499 0.644 rs10012252 chr4:120559139 T/C cg09307838 chr4:120376055 NA 0.64 9.67 0.47 1.12e-19 Corneal astigmatism; LUSC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 5.88 0.31 1.02e-8 Mean platelet volume; LUSC cis rs2247341 1.000 rs34049648 chr4:1697337 G/A cg07465881 chr4:1713556 SLBP -0.38 -5.77 -0.3 1.85e-8 Hip circumference adjusted for BMI;Height; LUSC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg23172400 chr8:95962367 TP53INP1 -0.39 -7.95 -0.4 2.97e-14 Type 2 diabetes; LUSC cis rs17270561 0.636 rs6456697 chr6:25741434 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.64 0.39 2.25e-13 Iron status biomarkers; LUSC cis rs9646954 0.542 rs11674830 chr2:101024735 A/G cg12002119 chr2:101014098 CHST10 0.36 5.93 0.31 7.72e-9 Intelligence (multi-trait analysis); LUSC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg23625390 chr15:77176239 SCAPER 0.48 7.3 0.37 2.18e-12 Blood metabolite levels; LUSC cis rs1003719 0.762 rs2835590 chr21:38463406 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs977987 0.836 rs17685540 chr16:75323840 T/C cg03315344 chr16:75512273 CHST6 0.47 8.63 0.43 2.56e-16 Dupuytren's disease; LUSC cis rs72781680 1.000 rs72781634 chr2:24199102 C/T cg08917208 chr2:24149416 ATAD2B 0.9 10.1 0.48 4.33e-21 Lymphocyte counts; LUSC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg18302933 chr2:88491318 NA -0.38 -7.51 -0.38 5.31e-13 Response to metformin (IC50); LUSC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg21138405 chr5:131827807 IRF1 -0.33 -5.81 -0.3 1.45e-8 Breast cancer;Mosquito bite size; LUSC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg21951975 chr1:209979733 IRF6 0.56 6.8 0.35 4.72e-11 Coronary artery disease; LUSC cis rs2479724 0.870 rs6913232 chr6:41915143 C/T cg17623882 chr6:41773611 USP49 0.55 8.8 0.43 7.59e-17 Menarche (age at onset); LUSC cis rs7568458 0.870 rs1562323 chr2:85809711 T/C cg17127132 chr2:85788382 GGCX 0.47 7.54 0.38 4.38e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs950169 0.544 rs2036949 chr15:85163605 T/C cg17507749 chr15:85114479 UBE2QP1 0.56 7.12 0.36 6.7e-12 Schizophrenia; LUSC cis rs17102423 0.731 rs998247 chr14:65546299 C/T cg11161011 chr14:65562177 MAX -0.67 -10.17 -0.49 2.42e-21 Obesity-related traits; LUSC cis rs4776059 0.798 rs13329393 chr15:52920505 A/T cg22715398 chr15:52968154 KIAA1370 0.57 7.39 0.37 1.19e-12 Schizophrenia; LUSC cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg11871910 chr12:69753446 YEATS4 -0.61 -9.0 -0.44 1.68e-17 Blood protein levels; LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 13.4 0.59 4.48e-33 Alzheimer's disease; LUSC cis rs877282 1.000 rs71491304 chr10:772982 C/T cg17470449 chr10:769945 NA 0.5 7.0 0.36 1.41e-11 Uric acid levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20165884 chr8:96281478 C8orf37 0.49 7.31 0.37 1.98e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9868809 0.772 rs2286651 chr3:48694147 G/A cg00383909 chr3:49044727 WDR6 1.1 9.83 0.47 3.28e-20 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs35110281 0.574 rs1836856 chr21:44964638 A/T cg01579765 chr21:45077557 HSF2BP -0.5 -10.42 -0.5 3.2800000000000002e-22 Mean corpuscular volume; LUSC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg06850241 chr22:41845214 NA 0.34 6.19 0.32 1.79e-9 Vitiligo; LUSC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg05738196 chr6:26577821 NA 0.53 8.32 0.41 2.23e-15 Schizophrenia; LUSC cis rs710216 0.917 rs2297977 chr1:43415288 G/T cg03128534 chr1:43423976 SLC2A1 0.46 5.97 0.31 6.19e-9 Red cell distribution width; LUSC cis rs11098499 0.954 rs1480931 chr4:120395809 G/T cg24375607 chr4:120327624 NA 0.8 12.18 0.55 1.76e-28 Corneal astigmatism; LUSC cis rs981844 0.683 rs1105496 chr4:154756755 T/C cg14289246 chr4:154710475 SFRP2 -0.47 -6.51 -0.34 2.69e-10 Response to statins (LDL cholesterol change); LUSC cis rs9905704 0.846 rs302851 chr17:56685424 G/A cg12560992 chr17:57184187 TRIM37 0.56 8.07 0.4 1.28e-14 Testicular germ cell tumor; LUSC cis rs2273669 0.667 rs11153139 chr6:109279381 C/T cg05315195 chr6:109294784 ARMC2 -0.59 -6.61 -0.34 1.55e-10 Prostate cancer; LUSC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg21028142 chr17:79581711 NPLOC4 0.34 8.16 0.41 7.03e-15 Eye color traits; LUSC cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.32 0.53 2.37e-25 Colorectal cancer; LUSC cis rs34638657 0.732 rs12597534 chr16:82200276 G/T cg09439754 chr16:82129088 HSD17B2 -0.37 -6.25 -0.32 1.26e-9 Lung adenocarcinoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg26147372 chr3:49130904 QRICH1 -0.42 -6.2 -0.32 1.62e-9 Electrocardiographic conduction measures; LUSC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg16447950 chr5:562315 NA -0.58 -7.11 -0.36 7.26e-12 Obesity-related traits; LUSC cis rs847577 0.630 rs2132276 chr7:97826340 G/A cg21770322 chr7:97807741 LMTK2 0.56 10.07 0.48 5.2e-21 Breast cancer; LUSC cis rs1387259 0.570 rs12368659 chr12:48562299 C/A cg24011408 chr12:48396354 COL2A1 0.4 5.8 0.3 1.55e-8 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg13395646 chr4:1353034 KIAA1530 -0.65 -10.25 -0.49 1.32e-21 Obesity-related traits; LUSC cis rs79149102 0.579 rs2304904 chr15:75315975 G/A cg17294928 chr15:75287854 SCAMP5 -0.76 -6.55 -0.34 2.11e-10 Lung cancer; LUSC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg05472934 chr7:22766657 IL6 0.52 8.57 0.42 4.03e-16 Lung cancer; LUSC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg15445000 chr17:37608096 MED1 0.37 6.35 0.33 7.09e-10 Glomerular filtration rate (creatinine); LUSC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.6 7.59 0.38 3.24e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg08847533 chr14:75593920 NEK9 -0.83 -15.44 -0.65 5.91e-41 Height; LUSC cis rs7940866 0.834 rs10791105 chr11:130839161 A/G cg12179176 chr11:130786555 SNX19 0.57 8.58 0.43 3.5e-16 Schizophrenia; LUSC cis rs11623869 0.772 rs12587310 chr14:103907286 G/A cg12935359 chr14:103987150 CKB 0.57 8.62 0.43 2.8e-16 Bone mineral density; LUSC cis rs1153858 0.723 rs4580098 chr15:45596909 T/A cg21132104 chr15:45694354 SPATA5L1 0.53 7.09 0.36 7.81e-12 Homoarginine levels; LUSC cis rs2200578 1.000 rs62153845 chr2:99887162 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 0.57 6.55 0.34 2.16e-10 IgG glycosylation; LUSC cis rs6005807 0.719 rs73430189 chr22:29004881 C/A cg12565055 chr22:29076175 TTC28 0.54 5.79 0.3 1.62e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs660498 0.507 rs11015783 chr10:27729745 A/G cg04084786 chr10:27609163 NA 0.39 5.75 0.3 1.99e-8 Asthma (childhood onset); LUSC cis rs11971779 0.680 rs6467848 chr7:139080205 T/A cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg04850211 chr1:228464232 OBSCN 0.32 5.7 0.3 2.7e-8 Diastolic blood pressure; LUSC cis rs854765 0.505 rs2955358 chr17:17946623 A/G cg04398451 chr17:18023971 MYO15A 0.57 9.52 0.46 3.67e-19 Total body bone mineral density; LUSC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg18099408 chr3:52552593 STAB1 -0.4 -6.96 -0.36 1.81e-11 Bipolar disorder; LUSC cis rs9926296 0.656 rs4522419 chr16:89853307 T/C cg03605463 chr16:89740564 NA -0.39 -5.65 -0.3 3.51e-8 Vitiligo; LUSC trans rs561341 1.000 rs564714 chr17:30318404 C/T cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs977987 0.778 rs11862719 chr16:75431708 T/A cg04384234 chr16:75411784 CFDP1 -0.41 -6.77 -0.35 5.88e-11 Dupuytren's disease; LUSC cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg11102782 chr19:18549136 ISYNA1 -0.35 -6.54 -0.34 2.3e-10 Breast cancer; LUSC cis rs711245 1.000 rs848602 chr2:36778372 G/A cg01206211 chr2:36825736 FEZ2 0.37 7.68 0.39 1.78e-13 Height; LUSC cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg04450456 chr4:17643702 FAM184B 0.38 6.4 0.33 5.4e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg22875332 chr1:76189707 ACADM -0.42 -6.16 -0.32 2.09e-9 Daytime sleep phenotypes; LUSC cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg18252515 chr7:66147081 NA -0.59 -8.15 -0.41 7.17e-15 Corneal structure; LUSC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.2 0.41 5.24e-15 Homoarginine levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03144560 chr20:55043299 C20orf43 -0.51 -6.18 -0.32 1.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs506338 0.517 rs530252 chr11:64443465 T/C cg19395706 chr11:64412079 NRXN2 0.29 5.83 0.3 1.31e-8 Body mass index;Urate levels; LUSC cis rs6541297 0.887 rs4846906 chr1:230284257 C/A cg05784532 chr1:230284198 GALNT2 0.65 9.18 0.45 4.63e-18 Coronary artery disease; LUSC trans rs7976838 0.614 rs17122837 chr12:60073907 C/T cg04017131 chr8:6419570 ANGPT2;MCPH1 0.66 5.95 0.31 6.71e-9 Response to zileuton treatment in asthma (FEV1 change interaction); LUSC cis rs1023500 0.551 rs133355 chr22:42440285 G/A cg15557168 chr22:42548783 NA -0.42 -6.42 -0.33 4.81e-10 Schizophrenia; LUSC cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg23711669 chr6:146136114 FBXO30 0.82 14.52 0.62 2.22e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg12560992 chr17:57184187 TRIM37 0.9 17.24 0.69 4.15e-48 Intelligence (multi-trait analysis); LUSC cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 6.01 0.31 4.86e-9 Rheumatoid arthritis; LUSC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg06008330 chr7:65541103 ASL 0.4 6.15 0.32 2.16e-9 Aortic root size; LUSC cis rs1878931 0.624 rs39728 chr16:3453076 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.62 8.94 0.44 2.76e-17 Body mass index (adult); LUSC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs1577917 1.000 rs68171315 chr6:86707400 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.73 -0.43 1.28e-16 Response to antipsychotic treatment; LUSC cis rs11167764 1.000 rs11167764 chr5:141479065 A/C cg23435118 chr5:141488016 NDFIP1 -0.57 -8.14 -0.41 8.06e-15 Crohn's disease; LUSC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.28 0.53 3.13e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg13010199 chr12:38710504 ALG10B 0.67 10.28 0.49 1.01e-21 Morning vs. evening chronotype; LUSC cis rs4891159 0.790 rs4891018 chr18:74127082 A/T cg24786174 chr18:74118243 ZNF516 -0.83 -15.33 -0.64 1.55e-40 Longevity; LUSC cis rs2303282 0.716 rs2440467 chr16:56417047 C/T cg00500540 chr16:56394104 NA 0.43 7.34 0.37 1.68e-12 Breast cancer; LUSC cis rs6500602 0.627 rs863501 chr16:4588394 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.56 -7.09 -0.36 8.08e-12 Schizophrenia; LUSC cis rs2857891 0.817 rs2638101 chr11:6969131 G/A cg04053776 chr11:6947353 ZNF215 0.41 5.76 0.3 1.87e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs977987 0.778 rs12929908 chr16:75462071 C/T cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg07936489 chr17:37558343 FBXL20 -0.71 -10.01 -0.48 8.51e-21 Glomerular filtration rate (creatinine); LUSC cis rs34779708 0.733 rs60553075 chr10:35542462 T/A cg03585969 chr10:35415529 CREM 0.55 7.63 0.39 2.51e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg05738196 chr6:26577821 NA -0.58 -6.79 -0.35 5.04e-11 Intelligence (multi-trait analysis); LUSC cis rs9653442 0.545 rs11123814 chr2:100767082 A/G cg22139774 chr2:100720529 AFF3 -0.42 -7.23 -0.37 3.33e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg05256304 chr11:116969870 SIK3 0.29 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.52 8.52 0.42 5.75e-16 Lymphocyte counts; LUSC cis rs6574644 1.000 rs10149489 chr14:81776403 G/C cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC cis rs11971779 0.648 rs28754644 chr7:139065057 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.98 0.31 5.88e-9 Menopause (age at onset); LUSC cis rs1387259 0.859 rs2054905 chr12:48687951 A/G cg04545296 chr12:48745243 ZNF641 0.34 6.27 0.32 1.14e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.25 -0.41 3.75e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs62400317 0.859 rs12193812 chr6:45140761 C/T cg20913747 chr6:44695427 NA -0.47 -7.52 -0.38 5.13e-13 Total body bone mineral density; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg26839812 chr6:16129282 MYLIP 0.4 6.09 0.32 3.19e-9 Schizophrenia; LUSC cis rs1461503 0.934 rs7121840 chr11:122845360 A/G cg27398637 chr11:122830231 C11orf63 -0.41 -6.57 -0.34 1.98e-10 Menarche (age at onset); LUSC cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.46 6.92 0.35 2.33e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9910055 0.571 rs28897216 chr17:42240824 A/G cg16434002 chr17:42200994 HDAC5 -0.46 -6.57 -0.34 1.98e-10 Total body bone mineral density; LUSC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg13628971 chr7:2884303 GNA12 0.46 6.78 0.35 5.58e-11 Height; LUSC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs4409675 0.576 rs2749119 chr1:28236248 G/A cg23691781 chr1:28212827 C1orf38 0.33 7.98 0.4 2.3e-14 Corneal astigmatism; LUSC cis rs644799 0.526 rs542509 chr11:95641602 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.56 8.32 0.41 2.21e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs72781680 0.846 rs72780198 chr2:24014883 T/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs7923609 0.967 rs2393966 chr10:65134814 T/G cg01631684 chr10:65280961 REEP3 -0.38 -5.89 -0.31 9.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC cis rs9788721 0.902 rs7180002 chr15:78873993 A/T cg06917634 chr15:78832804 PSMA4 -0.44 -5.87 -0.31 1.05e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs3008870 1.000 rs2182143 chr1:67378936 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.26 0.64 2.81e-40 Lymphocyte percentage of white cells; LUSC cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg23711669 chr6:146136114 FBXO30 0.76 13.72 0.6 2.65e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg08219700 chr8:58056026 NA -0.64 -8.05 -0.4 1.52e-14 Developmental language disorder (linguistic errors); LUSC cis rs10832963 0.847 rs4237722 chr11:18639363 T/C cg09201001 chr11:18656081 SPTY2D1 0.89 13.83 0.6 1.06e-34 Breast cancer; LUSC cis rs28785552 0.966 rs7247272 chr19:53236331 C/T cg10871876 chr19:53194124 ZNF83 -0.56 -8.68 -0.43 1.76e-16 Response to paliperidone in schizophrenia (PANSS score); LUSC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.67e-8 Aortic root size; LUSC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg02423579 chr7:2872169 GNA12 -0.48 -6.84 -0.35 3.81e-11 Height; LUSC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg18876405 chr7:65276391 NA 0.67 11.9 0.55 1.85e-27 Aortic root size; LUSC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.45 -7.4 -0.38 1.13e-12 Bipolar disorder; LUSC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg12463550 chr7:65579703 CRCP 0.46 6.64 0.34 1.27e-10 Aortic root size; LUSC trans rs12412942 1.000 rs12412942 chr10:2357702 C/T cg06775055 chr4:18023265 LCORL 0.36 6.03 0.31 4.39e-9 Schizophrenia; LUSC cis rs11190604 1.000 rs12358187 chr10:102284449 C/G cg23241863 chr10:102295624 HIF1AN 0.48 5.74 0.3 2.18e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 13.66 0.6 4.5e-34 Platelet count; LUSC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg13393036 chr8:95962371 TP53INP1 -0.38 -7.96 -0.4 2.67e-14 Type 2 diabetes; LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg10802521 chr3:52805072 NEK4 -0.48 -7.51 -0.38 5.3e-13 Electroencephalogram traits; LUSC cis rs921665 0.831 rs7566188 chr2:3199057 C/T cg02624386 chr2:3182749 NA 0.59 6.41 0.33 5.09e-10 World class endurance athleticism; LUSC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg03676636 chr4:99064102 C4orf37 0.33 7.35 0.37 1.51e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs67460515 0.563 rs34630898 chr3:160827038 A/G cg03342759 chr3:160939853 NMD3 -0.45 -6.3 -0.33 9.2e-10 Parkinson's disease; LUSC cis rs1451375 0.617 rs11772714 chr7:50542843 G/A cg18232548 chr7:50535776 DDC -0.54 -7.55 -0.38 4.08e-13 Malaria; LUSC trans rs11098499 0.863 rs3822191 chr4:120428101 A/T cg25214090 chr10:38739885 LOC399744 0.52 7.59 0.38 3.33e-13 Corneal astigmatism; LUSC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg04369109 chr6:150039330 LATS1 -0.59 -8.63 -0.43 2.61e-16 Lung cancer; LUSC cis rs1982963 1.000 rs3818187 chr14:52509788 A/G cg10843707 chr14:52510701 NID2 0.42 7.27 0.37 2.59e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg01884057 chr2:25150051 NA 0.49 11.34 0.53 1.91e-25 Body mass index; LUSC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg17366294 chr4:99064904 C4orf37 -0.6 -10.88 -0.51 8.36e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs3806843 0.576 rs246011 chr5:140336405 G/C cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.26e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs9513627 0.510 rs4365162 chr13:100212614 G/C cg25919922 chr13:100150906 NA 0.81 6.7 0.34 8.73e-11 Obesity-related traits; LUSC cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg24642439 chr20:33292090 TP53INP2 0.72 10.89 0.51 7.78e-24 Coronary artery disease; LUSC cis rs4443100 0.670 rs13056137 chr22:23407261 C/A cg14186256 chr22:23484241 RTDR1 0.54 6.98 0.36 1.64e-11 Serum parathyroid hormone levels; LUSC cis rs208520 1.000 rs12195505 chr6:66986279 T/A cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs11048434 0.736 rs12823100 chr12:9108908 C/A cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg17420585 chr12:42539391 GXYLT1 -0.39 -7.85 -0.39 5.79e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg08888203 chr3:10149979 C3orf24 0.6 8.28 0.41 3e-15 Alzheimer's disease; LUSC cis rs2472297 1.000 rs2472297 chr15:75027880 A/G cg10253484 chr15:75165896 SCAMP2 0.49 5.74 0.3 2.17e-8 Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level);Coffee consumption (cups per day);Coffee consumption;Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level);Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio); LUSC cis rs1448094 0.645 rs12301701 chr12:86472798 C/T cg00310523 chr12:86230176 RASSF9 -0.33 -5.97 -0.31 5.98e-9 Major depressive disorder; LUSC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg06713675 chr4:122721982 EXOSC9 -0.67 -11.64 -0.54 1.63e-26 Type 2 diabetes; LUSC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg15556689 chr8:8085844 FLJ10661 0.77 12.42 0.56 2.24e-29 Neuroticism; LUSC cis rs754466 0.580 rs10824573 chr10:79540969 T/C cg17075019 chr10:79541650 NA -0.78 -12.4 -0.56 2.7e-29 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs61931739 0.513 rs7956626 chr12:33901640 C/T cg26384229 chr12:38710491 ALG10B 0.57 8.9 0.44 3.58e-17 Morning vs. evening chronotype; LUSC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg18681998 chr4:17616180 MED28 0.85 15.88 0.66 1.1e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.84e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.29 0.53 2.88e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg27494647 chr7:150038898 RARRES2 0.46 6.87 0.35 3.06e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg13319975 chr6:146136371 FBXO30 0.49 7.39 0.37 1.19e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.44 -6.71 -0.34 8.59e-11 Mean platelet volume; LUSC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.95 0.48 1.3e-20 Personality dimensions; LUSC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg09998033 chr7:158218633 PTPRN2 -0.61 -9.77 -0.47 5.28e-20 Obesity-related traits; LUSC cis rs2073300 1.000 rs6132626 chr20:23444672 T/C cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2346177 0.875 rs2881327 chr2:46641955 A/G cg02822958 chr2:46747628 ATP6V1E2 0.36 6.2 0.32 1.62e-9 HDL cholesterol; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.13 0.41 8.35e-15 Prudent dietary pattern; LUSC cis rs1358748 0.520 rs2093333 chr1:67532103 G/A cg02640540 chr1:67518911 SLC35D1 0.62 6.52 0.34 2.6e-10 Tuberculosis; LUSC cis rs12893668 0.667 rs11844466 chr14:104066422 G/A cg08213375 chr14:104286397 PPP1R13B 0.4 6.98 0.36 1.6e-11 Reticulocyte count; LUSC cis rs11630290 0.617 rs12440886 chr15:64172899 A/G cg12036633 chr15:63758958 NA 0.69 7.28 0.37 2.49e-12 Iris characteristics; LUSC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg08773314 chr2:239334832 ASB1 0.43 9.26 0.45 2.6e-18 Multiple system atrophy; LUSC cis rs3820068 0.603 rs17448778 chr1:15985306 A/G cg24675056 chr1:15929824 NA 0.44 7.64 0.39 2.28e-13 Systolic blood pressure; LUSC cis rs921968 0.643 rs537520 chr2:219381852 A/G cg02176678 chr2:219576539 TTLL4 0.61 11.16 0.52 8.41e-25 Mean corpuscular hemoglobin concentration; LUSC cis rs2050392 0.767 rs1536833 chr10:30699265 C/T cg25182066 chr10:30743637 MAP3K8 0.43 6.06 0.31 3.63e-9 Inflammatory bowel disease; LUSC trans rs12639258 0.506 rs6808142 chr3:46556835 C/T cg00260888 chr20:30865478 KIF3B 0.39 6.06 0.31 3.73e-9 Eotaxin levels; LUSC cis rs8135665 0.600 rs3026682 chr22:38452482 G/A cg13116946 chr22:38479732 SLC16A8 0.43 6.32 0.33 8.29e-10 Advanced age-related macular degeneration;Age-related macular degeneration; LUSC cis rs11864453 0.762 rs6416742 chr16:72149061 C/T cg23815491 chr16:72088622 HP 0.37 6.4 0.33 5.41e-10 Fibrinogen levels; LUSC cis rs877282 0.842 rs35872126 chr10:764545 G/A cg17470449 chr10:769945 NA 0.53 7.12 0.36 6.81e-12 Uric acid levels; LUSC cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg11766577 chr21:47581405 C21orf56 -0.38 -5.71 -0.3 2.54e-8 Testicular germ cell tumor; LUSC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg03264133 chr6:25882463 NA -0.45 -7.52 -0.38 5.26e-13 Intelligence (multi-trait analysis); LUSC cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg13010199 chr12:38710504 ALG10B -0.64 -10.89 -0.51 7.99e-24 Heart rate; LUSC cis rs7772486 0.875 rs2748490 chr6:146329681 G/T cg13319975 chr6:146136371 FBXO30 -0.47 -7.08 -0.36 8.49e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs4812048 0.649 rs116580814 chr20:57618141 G/T cg14073986 chr20:57617431 SLMO2 0.93 9.65 0.47 1.38e-19 Mean platelet volume; LUSC cis rs7520050 0.807 rs6671802 chr1:46124663 A/G cg06784218 chr1:46089804 CCDC17 0.29 5.83 0.3 1.31e-8 Red blood cell count;Reticulocyte count; LUSC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs2073300 1.000 rs12626013 chr20:23442215 G/A cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6815814 0.950 rs11722813 chr4:38810769 C/T cg02016764 chr4:38805732 TLR1 -0.54 -5.98 -0.31 5.63e-9 Breast cancer; LUSC cis rs7428 0.847 rs1969260 chr2:85568810 C/T cg24342717 chr2:85555507 TGOLN2 -0.57 -8.36 -0.42 1.71e-15 Ear protrusion; LUSC cis rs11608355 0.545 rs35018715 chr12:109893134 T/C cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs56804039 1.000 rs56804039 chr8:8381029 C/G cg15556689 chr8:8085844 FLJ10661 -0.56 -6.96 -0.36 1.84e-11 Cervical cancer; LUSC cis rs7178572 0.625 rs12904553 chr15:77845959 G/A cg22256960 chr15:77711686 NA -0.44 -7.09 -0.36 7.98e-12 Type 2 diabetes; LUSC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg26897989 chr16:1907736 C16orf73 -0.45 -7.01 -0.36 1.36e-11 Glomerular filtration rate in chronic kidney disease; LUSC cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg08975724 chr8:8085496 FLJ10661 -0.47 -6.88 -0.35 3.05e-11 Mood instability; LUSC cis rs8092503 1.000 rs2871673 chr18:52491427 G/T cg12377874 chr18:52495404 RAB27B -0.34 -6.16 -0.32 2.09e-9 Childhood body mass index; LUSC cis rs1018836 0.632 rs1028255 chr8:91485578 A/T cg16814680 chr8:91681699 NA -0.65 -9.78 -0.47 4.93e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg04539111 chr16:67997858 SLC12A4 -0.46 -6.27 -0.32 1.1e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 7.58 0.38 3.4e-13 Reticulocyte count; LUSC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg03452623 chr4:187889614 NA -0.78 -13.54 -0.6 1.38e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 11.97 0.55 1.01e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs34421088 0.560 rs2248315 chr8:11397086 T/A cg06636001 chr8:8085503 FLJ10661 -0.58 -9.05 -0.44 1.19e-17 Neuroticism; LUSC cis rs7954584 0.813 rs12827200 chr12:122451278 G/A cg13699009 chr12:122356056 WDR66 0.44 6.81 0.35 4.49e-11 Mean corpuscular volume; LUSC cis rs73198271 0.694 rs113694763 chr8:8647076 C/T cg01851573 chr8:8652454 MFHAS1 0.52 8.12 0.41 9.04e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6845621 0.901 rs1377154 chr4:18924301 A/G cg12196642 chr4:18937545 NA -0.36 -6.67 -0.34 1.03e-10 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9457247 0.561 rs916331 chr6:167470559 T/G cg07741184 chr6:167504864 NA 0.49 8.55 0.42 4.6e-16 Crohn's disease; LUSC cis rs4975616 0.804 rs381949 chr5:1322468 G/A cg26373071 chr5:1325741 CLPTM1L 0.4 7.36 0.37 1.48e-12 Lung cancer; LUSC trans rs208520 0.634 rs3909071 chr6:66836947 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.11 -16.75 -0.68 3.85e-46 Exhaled nitric oxide output; LUSC cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg15557168 chr22:42548783 NA -0.43 -7.06 -0.36 9.42e-12 Schizophrenia; LUSC cis rs7560272 0.723 rs7609249 chr2:73813820 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -7.36 -0.37 1.45e-12 Schizophrenia; LUSC cis rs4805272 0.512 rs7260055 chr19:29341599 G/A cg03161606 chr19:29218774 NA 0.51 5.98 0.31 5.58e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs662064 0.962 rs660725 chr1:10557544 A/G cg20482658 chr1:10539492 PEX14 -0.31 -6.46 -0.33 3.75e-10 Asthma; LUSC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg17554472 chr22:41940697 POLR3H -0.48 -5.76 -0.3 1.89e-8 Vitiligo; LUSC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg13047869 chr3:10149882 C3orf24 0.57 7.9 0.4 4.11e-14 Alzheimer's disease; LUSC trans rs7824557 0.564 rs2572395 chr8:11235360 A/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.53 -0.34 2.4e-10 Retinal vascular caliber; LUSC cis rs11264213 0.901 rs116757422 chr1:36349560 G/A cg27506609 chr1:36549197 TEKT2 0.7 8.04 0.4 1.62e-14 Schizophrenia; LUSC cis rs9467773 0.534 rs34453863 chr6:26628005 T/C cg11502198 chr6:26597334 ABT1 0.69 11.09 0.52 1.54e-24 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg21724239 chr8:58056113 NA 0.77 8.37 0.42 1.55e-15 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg06145435 chr7:1022769 CYP2W1 0.32 6.68 0.34 9.72e-11 Longevity;Endometriosis; LUSC cis rs2014572 0.967 rs7259978 chr19:57756129 C/T cg24459738 chr19:57751996 ZNF805 -0.52 -7.69 -0.39 1.66e-13 Hyperactive-impulsive symptoms; LUSC cis rs1577917 1.000 rs11758849 chr6:86708262 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.49 -7.13 -0.36 6.17e-12 Response to antipsychotic treatment; LUSC cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg13256891 chr4:100009986 ADH5 0.51 6.96 0.36 1.79e-11 Smoking initiation; LUSC cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.65 0.86 4.24e-99 Chronic sinus infection; LUSC cis rs1728785 1.000 rs1645928 chr16:68590610 G/T cg02972257 chr16:68554789 NA -0.5 -6.28 -0.32 1.08e-9 Ulcerative colitis; LUSC cis rs61990749 0.597 rs4903643 chr14:78254791 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.61 6.34 0.33 7.46e-10 Fibroblast growth factor basic levels; LUSC cis rs295140 0.732 rs1367858 chr2:201160771 C/T cg04283868 chr2:201171347 SPATS2L 0.44 6.3 0.33 9.37e-10 QT interval; LUSC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg11812906 chr14:75593930 NEK9 0.66 11.4 0.53 1.23e-25 Height; LUSC cis rs11608355 0.545 rs4766473 chr12:109900596 C/T cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs17401966 0.558 rs6541090 chr1:10402842 A/G cg19773385 chr1:10388646 KIF1B -0.34 -5.93 -0.31 7.73e-9 Hepatocellular carcinoma; LUSC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg16423285 chr20:60520624 NA 0.64 8.08 0.4 1.22e-14 Body mass index; LUSC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg06873352 chr17:61820015 STRADA 0.71 12.72 0.57 1.68e-30 Prudent dietary pattern; LUSC cis rs3768617 0.811 rs12138053 chr1:182979560 C/T ch.1.3577855R chr1:183094577 LAMC1 0.59 8.5 0.42 6.51e-16 Fuchs's corneal dystrophy; LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg01516881 chr6:292596 DUSP22 -0.7 -11.32 -0.53 2.39e-25 Menopause (age at onset); LUSC cis rs10887741 0.624 rs7088341 chr10:89427820 C/T cg13926569 chr10:89418898 PAPSS2 0.32 6.87 0.35 3.08e-11 Exercise (leisure time); LUSC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg20476274 chr7:133979776 SLC35B4 0.81 14.7 0.63 4.31e-38 Mean platelet volume; LUSC cis rs807669 0.903 rs807667 chr22:19161327 A/G cg02655711 chr22:19163373 SLC25A1 -0.9 -18.17 -0.71 8.55e-52 Metabolite levels; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg21782813 chr7:2030301 MAD1L1 0.48 8.12 0.41 9.02e-15 Bipolar disorder and schizophrenia; LUSC cis rs17095355 1.000 rs12267714 chr10:111722052 C/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.49 -0.38 6.22e-13 Biliary atresia; LUSC cis rs7590368 0.748 rs72779478 chr2:10967124 C/T cg15705551 chr2:10952987 PDIA6 0.6 6.57 0.34 1.96e-10 Educational attainment (years of education); LUSC cis rs2067615 0.524 rs9971765 chr12:107092299 G/A cg15890332 chr12:107067104 RFX4 0.35 6.3 0.33 9.61e-10 Heart rate; LUSC cis rs9788682 0.747 rs2869045 chr15:78718899 T/C cg24631222 chr15:78858424 CHRNA5 -0.7 -9.1 -0.45 8.06e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs668210 0.793 rs522553 chr11:65771669 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.58 7.79 0.39 8.81e-14 Cerebrospinal fluid biomarker levels; LUSC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 0.32 6.1 0.32 2.85e-9 Schizophrenia; LUSC cis rs314370 1.000 rs12705089 chr7:100465355 C/T cg10426581 chr7:100472382 SRRT 0.86 12.4 0.56 2.74e-29 Resting heart rate; LUSC cis rs7799006 0.929 rs7781856 chr7:2257199 C/T cg02951883 chr7:2050386 MAD1L1 -0.36 -6.09 -0.32 3.19e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg04414720 chr1:150670196 GOLPH3L 0.51 8.18 0.41 6e-15 Blood protein levels; LUSC cis rs2970818 0.831 rs7958162 chr12:4600634 T/A cg11146114 chr12:4671731 NA -0.59 -6.11 -0.32 2.76e-9 Phosphorus levels; LUSC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg20243544 chr17:37824526 PNMT 0.52 7.41 0.38 1.02e-12 Asthma; LUSC cis rs6750047 0.719 rs1583171 chr2:38270107 G/A cg07380506 chr2:38303506 CYP1B1 0.41 5.65 0.3 3.36e-8 Cutaneous malignant melanoma;Melanoma; LUSC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg04756594 chr16:24857601 SLC5A11 0.49 6.94 0.35 2.09e-11 Intelligence (multi-trait analysis); LUSC cis rs3126085 0.935 rs1390487 chr1:152194601 G/A cg26876637 chr1:152193138 HRNR 0.45 6.48 0.33 3.21e-10 Atopic dermatitis; LUSC cis rs13418410 0.668 rs4670206 chr2:33796334 T/A cg04131969 chr2:33951647 MYADML -0.45 -6.05 -0.31 3.87e-9 Non-response to antidepressants and depression; LUSC cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg23649088 chr2:200775458 C2orf69 0.59 7.28 0.37 2.36e-12 Schizophrenia; LUSC cis rs8077889 1.000 rs2342310 chr17:41866199 T/C cg26893861 chr17:41843967 DUSP3 1.01 15.04 0.64 2.13e-39 Triglycerides; LUSC cis rs7681440 0.904 rs3756063 chr4:90757394 G/C cg15133208 chr4:90757351 SNCA -0.34 -5.99 -0.31 5.29e-9 Dementia with Lewy bodies; LUSC cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg18681998 chr4:17616180 MED28 -0.81 -14.34 -0.62 1.09e-36 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.87 0.35 3.09e-11 Parkinson's disease; LUSC cis rs2073300 1.000 rs6137980 chr20:23466726 G/T cg09953122 chr20:23471693 CST8 -0.87 -6.98 -0.36 1.59e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1153858 1.000 rs2461702 chr15:45647427 A/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.28 0.49 1.04e-21 Homoarginine levels; LUSC cis rs67460515 0.892 rs7648279 chr3:160979646 G/A cg03342759 chr3:160939853 NMD3 -0.55 -8.13 -0.41 8.77e-15 Parkinson's disease; LUSC cis rs2857891 0.695 rs2248341 chr11:6984677 A/T cg04053776 chr11:6947353 ZNF215 0.41 6.06 0.31 3.65e-9 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs6545883 0.503 rs1665272 chr2:61379286 A/C cg15711740 chr2:61764176 XPO1 -0.39 -6.13 -0.32 2.41e-9 Tuberculosis; LUSC cis rs1559088 1.000 rs12979164 chr19:33553228 G/C cg27124370 chr19:33622961 WDR88 0.52 6.7 0.34 8.63e-11 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9300255 0.602 rs1790098 chr12:123655481 A/C cg05973401 chr12:123451056 ABCB9 0.52 6.45 0.33 4.04e-10 Neutrophil percentage of white cells; LUSC cis rs7666738 0.606 rs4699611 chr4:99097492 T/G cg03676636 chr4:99064102 C4orf37 0.28 5.92 0.31 8.19e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.53e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC trans rs3857536 0.813 rs7770349 chr6:66946659 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs477692 0.699 rs578932 chr10:131370724 C/A cg11019008 chr10:131425282 MGMT 0.42 5.98 0.31 5.6e-9 Response to temozolomide; LUSC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg13939156 chr17:80058883 NA -0.34 -6.76 -0.35 6.08e-11 Life satisfaction; LUSC cis rs9650315 0.866 rs4629840 chr8:57189267 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.55 7.01 0.36 1.33e-11 Height; LUSC cis rs2224391 0.628 rs2773311 chr6:5250866 A/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.49 -6.75 -0.35 6.5500000000000006e-11 Height; LUSC trans rs7681440 0.874 rs1442154 chr4:90775761 C/G cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.96 -0.31 6.49e-9 Dementia with Lewy bodies; LUSC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg13683864 chr3:40499215 RPL14 -1.14 -20.62 -0.75 1.65e-61 Renal cell carcinoma; LUSC cis rs4319547 0.695 rs4758662 chr12:122924778 G/A cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.52 -0.42 5.55e-16 Body mass index; LUSC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg06001716 chr17:41278141 BRCA1;NBR2 0.36 5.9 0.31 8.91e-9 Menopause (age at onset); LUSC cis rs6741892 0.793 rs34558770 chr2:38933040 C/T cg23643435 chr2:38893251 GALM -0.71 -5.67 -0.3 3.08e-8 5-HTT brain serotonin transporter levels; LUSC trans rs724744 0.741 rs1772080 chr6:22354220 G/A cg13807341 chr11:118445984 ARCN1 -0.36 -6.19 -0.32 1.77e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg02175503 chr12:58329896 NA 0.48 6.98 0.36 1.57e-11 Intelligence (multi-trait analysis); LUSC cis rs6547741 0.904 rs2384628 chr2:27774702 T/G cg27432699 chr2:27873401 GPN1 0.82 15.39 0.64 8.7e-41 Oral cavity cancer; LUSC trans rs2201841 0.501 rs11209032 chr1:67740092 G/A cg16262963 chr14:104851903 NA -0.23 -6.08 -0.32 3.3e-9 Ulcerative colitis;Psoriasis;Crohn's disease; LUSC cis rs35883536 0.513 rs6577180 chr1:101016939 G/A cg09408571 chr1:101003634 GPR88 0.33 6.48 0.33 3.28e-10 Monocyte count; LUSC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.95e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs394563 0.591 rs237016 chr6:149744859 T/C cg07828024 chr6:149772892 ZC3H12D -0.33 -7.27 -0.37 2.54e-12 Dupuytren's disease; LUSC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs478304 0.651 rs4014195 chr11:65506822 C/G cg05805236 chr11:65401703 PCNXL3 0.56 9.2 0.45 4.04e-18 Acne (severe); LUSC trans rs61931739 0.500 rs11053199 chr12:34450534 C/T cg13010199 chr12:38710504 ALG10B -0.6 -9.51 -0.46 4e-19 Morning vs. evening chronotype; LUSC cis rs7647973 1.000 rs2177268 chr3:49439725 A/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.45 -6.89 -0.35 2.81e-11 Menarche (age at onset); LUSC cis rs473651 0.506 rs561264 chr2:239329979 G/T cg21699342 chr2:239360505 ASB1 0.43 6.6 0.34 1.65e-10 Multiple system atrophy; LUSC cis rs9549367 0.789 rs2302754 chr13:113898385 C/T cg00898013 chr13:113819073 PROZ 0.53 7.64 0.39 2.28e-13 Platelet distribution width; LUSC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg19318889 chr4:1322082 MAEA 0.78 14.72 0.63 3.88e-38 Longevity; LUSC cis rs7851660 0.809 rs10984253 chr9:100664474 A/G cg13688889 chr9:100608707 NA -0.54 -8.43 -0.42 1.05e-15 Strep throat; LUSC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg23625390 chr15:77176239 SCAPER 0.46 7.0 0.36 1.44e-11 Blood metabolite levels; LUSC cis rs5758511 0.680 rs34107327 chr22:42648353 T/G cg00645731 chr22:42541494 CYP2D7P1 0.57 9.94 0.48 1.42e-20 Birth weight; LUSC cis rs477692 0.905 rs524545 chr10:131411840 A/C cg26102564 chr10:131424627 MGMT -0.38 -5.94 -0.31 7.31e-9 Response to temozolomide; LUSC cis rs5771242 0.769 rs4838865 chr22:50664612 A/G cg16473166 chr22:50639996 SELO 0.57 7.3 0.37 2.11e-12 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); LUSC cis rs6012953 1.000 rs932420 chr20:49133069 A/G cg13958625 chr20:49123093 NA 0.31 6.75 0.35 6.63e-11 Vitiligo; LUSC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg17971929 chr21:40555470 PSMG1 0.78 13.34 0.59 8.04e-33 Cognitive function; LUSC cis rs4704187 0.687 rs4235683 chr5:74415088 T/C cg03227963 chr5:74354835 NA 0.32 6.81 0.35 4.62e-11 Response to amphetamines; LUSC cis rs7089973 0.604 rs35319791 chr10:116602296 C/A cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg11247378 chr22:39784982 NA -0.66 -12.91 -0.58 3.4e-31 Intelligence (multi-trait analysis); LUSC cis rs2839186 0.504 rs11702278 chr21:47936295 T/G cg10657630 chr21:48055338 PRMT2 0.4 6.09 0.32 3.05e-9 Testicular germ cell tumor; LUSC cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg02175503 chr12:58329896 NA 0.68 10.86 0.51 1.01e-23 Intelligence (multi-trait analysis); LUSC trans rs10221833 0.636 rs355890 chr2:165634976 T/G cg26993132 chr16:89239499 CDH15 0.31 5.99 0.31 5.47e-9 Response to statin therapy; LUSC cis rs7605827 0.930 rs13015492 chr2:15505716 G/A cg19274914 chr2:15703543 NA 0.45 8.51 0.42 6.15e-16 Educational attainment (years of education); LUSC cis rs8141529 0.719 rs2097461 chr22:29191879 T/C cg15103426 chr22:29168792 CCDC117 0.58 8.09 0.4 1.12e-14 Lymphocyte counts; LUSC trans rs11098499 0.863 rs7695620 chr4:120452776 G/A cg25214090 chr10:38739885 LOC399744 0.53 7.72 0.39 1.33e-13 Corneal astigmatism; LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg19318889 chr4:1322082 MAEA 0.47 7.6 0.38 2.95e-13 Obesity-related traits; LUSC cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg08470875 chr2:26401718 FAM59B 0.73 9.9 0.48 2.05e-20 Gut microbiome composition (summer); LUSC cis rs6516091 0.640 rs6117070 chr20:6061606 A/G cg25325723 chr20:6104886 FERMT1 -0.61 -7.07 -0.36 9.14e-12 Abdominal aortic aneurysm; LUSC cis rs11637445 0.677 rs12441598 chr15:68073205 G/A cg08079166 chr15:68083412 MAP2K5 0.36 7.39 0.37 1.17e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg00078996 chr12:132293329 NA -0.35 -5.72 -0.3 2.4e-8 Migraine; LUSC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg00522288 chr12:125625016 AACS -0.31 -5.98 -0.31 5.86e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg03264133 chr6:25882463 NA -0.44 -7.44 -0.38 8.5e-13 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg12927641 chr6:109611667 NA -0.34 -5.77 -0.3 1.81e-8 Reticulocyte fraction of red cells; LUSC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg08219700 chr8:58056026 NA 0.5 6.32 0.33 8.6e-10 Developmental language disorder (linguistic errors); LUSC cis rs1696756 1.000 rs1696756 chr17:77827973 C/T cg00646381 chr17:77835854 NA 0.55 9.65 0.47 1.36e-19 Glucocorticoid-induced osteonecrosis (age 10 years and older); LUSC cis rs6433857 0.536 rs1971135 chr2:181351508 G/A cg23363182 chr2:181467187 NA -0.45 -7.25 -0.37 2.85e-12 Body mass index; LUSC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg21475434 chr5:93447410 FAM172A -0.71 -7.59 -0.38 3.22e-13 Diabetic retinopathy; LUSC cis rs7927771 0.542 rs7108479 chr11:47781460 G/T cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs713477 1.000 rs12893000 chr14:55912280 G/T cg13175173 chr14:55914753 NA -0.32 -6.69 -0.34 9.43e-11 Pediatric bone mineral content (femoral neck); LUSC trans rs12340987 0.636 rs12004117 chr9:87764076 C/G cg01663225 chr11:124492831 TBRG1 -0.68 -5.98 -0.31 5.89e-9 Birth weight; LUSC trans rs853679 0.517 rs35512245 chr6:28079953 T/C cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Depression; LUSC cis rs546131 0.928 rs553789 chr11:34827579 G/A cg11058730 chr11:34937778 PDHX;APIP 0.44 5.97 0.31 6.08e-9 Lung disease severity in cystic fibrosis; LUSC cis rs9902453 0.808 rs8069669 chr17:28239502 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.74 11.65 0.54 1.54e-26 Coffee consumption (cups per day); LUSC cis rs28647808 0.786 rs4962135 chr9:136256630 C/T cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -8.15 -0.41 7.57e-15 Body mass index (adult); LUSC cis rs6977660 0.714 rs10236607 chr7:19818620 A/G cg05791153 chr7:19748676 TWISTNB 0.65 6.9 0.35 2.67e-11 Thyroid stimulating hormone; LUSC cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -8.11 -0.41 9.5e-15 Body mass index (adult); LUSC cis rs8014204 0.550 rs2302832 chr14:75137664 T/C cg06637938 chr14:75390232 RPS6KL1 0.59 9.27 0.45 2.35e-18 Caffeine consumption; LUSC trans rs76248362 1.000 rs4770509 chr13:24438643 A/G cg26511321 chr7:27196790 HOXA7 0.53 6.18 0.32 1.91e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg02675527 chr2:114030824 PAX8;LOC440839 0.38 5.94 0.31 6.98e-9 Lymphocyte counts; LUSC cis rs9463078 0.683 rs6458412 chr6:44735834 A/G cg25276700 chr6:44698697 NA 0.32 6.36 0.33 6.8e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2282300 0.739 rs67670125 chr11:30214914 C/T cg25418670 chr11:30344373 C11orf46 -0.63 -9.01 -0.44 1.61e-17 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs11039100 0.850 rs11039116 chr11:5831551 T/A cg05234568 chr11:5960015 NA -0.51 -5.82 -0.3 1.36e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs10504073 0.631 rs341813 chr8:50039916 T/C cg00325661 chr8:49890786 NA 0.59 9.72 0.47 7.68e-20 Blood metabolite ratios; LUSC cis rs1160297 0.609 rs12713232 chr2:53108308 A/T cg07782112 chr2:53107842 NA -0.41 -6.93 -0.35 2.13e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs12908161 0.920 rs35758837 chr15:85311382 C/T cg12863693 chr15:85201151 NMB 0.41 8.48 0.42 7.34e-16 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11495060 chr7:100472765 SRRT -0.42 -6.27 -0.32 1.13e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.9 0.31 8.84e-9 Intelligence (multi-trait analysis); LUSC cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg26384229 chr12:38710491 ALG10B -0.96 -18.41 -0.71 9.53e-53 Heart rate; LUSC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg00522288 chr12:125625016 AACS -0.33 -5.99 -0.31 5.47e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg16680214 chr1:154839983 KCNN3 -0.53 -10.03 -0.48 7.38e-21 Prostate cancer; LUSC cis rs7659604 0.540 rs10004284 chr4:122699222 A/T cg20573242 chr4:122745356 CCNA2 -0.45 -6.73 -0.35 7.37e-11 Type 2 diabetes; LUSC cis rs12711979 1.000 rs12711979 chr2:3869559 A/G cg17052675 chr2:3827356 NA -0.44 -7.89 -0.4 4.23e-14 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs9303401 0.659 rs35797125 chr17:56736547 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.86 13.88 0.6 6.55e-35 Cognitive test performance; LUSC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11890956 chr21:40555474 PSMG1 -0.7 -10.05 -0.48 6.24e-21 Menarche (age at onset); LUSC cis rs3091242 0.933 rs932372 chr1:25755014 G/A cg02931644 chr1:25747376 RHCE 0.36 6.45 0.33 3.86e-10 Erythrocyte sedimentation rate; LUSC trans rs78049276 0.512 rs6855875 chr4:148402737 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.55 -6.38 -0.33 6.03e-10 Pulse pressure; LUSC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg06134567 chr22:46658398 PKDREJ -0.55 -6.31 -0.33 8.72e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg17845761 chr1:175162550 KIAA0040 0.31 5.93 0.31 7.53e-9 Alcohol dependence; LUSC cis rs12220238 1.000 rs11000922 chr10:75969305 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.9 0.35 2.64e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg12311346 chr5:56204834 C5orf35 -0.87 -13.56 -0.6 1.12e-33 Initial pursuit acceleration; LUSC trans rs9944715 1.000 rs9963153 chr18:43840064 A/G cg01718231 chr17:29326311 RNF135 -0.52 -7.22 -0.37 3.43e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18301423 chr5:131593218 PDLIM4 -0.5 -7.56 -0.38 4.05e-13 Acylcarnitine levels; LUSC cis rs6690583 0.623 rs2083283 chr1:85439996 C/A cg22153463 chr1:85462885 MCOLN2 0.64 6.15 0.32 2.15e-9 Serum sulfate level; LUSC cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg21171335 chr12:122356390 WDR66 -0.6 -8.94 -0.44 2.79e-17 Mean corpuscular volume; LUSC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg22166914 chr1:53195759 ZYG11B 0.48 7.61 0.38 2.74e-13 Monocyte count; LUSC trans rs62103177 0.713 rs62103186 chr18:77627574 G/C cg14227996 chr4:17616232 MED28 0.82 7.87 0.4 4.98e-14 Opioid sensitivity; LUSC cis rs714027 1.000 rs4823073 chr22:30512258 G/A cg11564601 chr22:30592435 NA -0.37 -6.78 -0.35 5.4e-11 Lymphocyte counts; LUSC cis rs7107174 0.901 rs7941639 chr11:78116959 A/G cg02023728 chr11:77925099 USP35 -0.41 -6.06 -0.31 3.65e-9 Testicular germ cell tumor; LUSC cis rs4629710 0.592 rs3777476 chr6:131533821 A/C cg12606694 chr6:131520996 AKAP7 0.6 8.97 0.44 2.17e-17 Multiple myeloma (IgH translocation); LUSC cis rs6967385 0.560 rs34130399 chr7:12356746 T/A cg20607287 chr7:12443886 VWDE 0.49 7.37 0.37 1.37e-12 Response to taxane treatment (placlitaxel); LUSC cis rs259282 0.574 rs4805780 chr19:33114406 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.68 10.0 0.48 8.82e-21 Schizophrenia; LUSC cis rs977987 0.872 rs4887816 chr16:75319716 T/C cg03315344 chr16:75512273 CHST6 0.47 8.61 0.43 2.88e-16 Dupuytren's disease; LUSC cis rs12712073 0.512 rs6710355 chr2:100699994 T/C cg22139774 chr2:100720529 AFF3 -0.39 -6.26 -0.32 1.2e-9 Intelligence (multi-trait analysis); LUSC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg13699009 chr12:122356056 WDR66 -0.49 -7.89 -0.4 4.26e-14 Mean corpuscular volume; LUSC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg04362960 chr10:104952993 NT5C2 0.59 9.44 0.46 6.59e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4654899 0.865 rs12119348 chr1:21484633 C/T cg01072550 chr1:21505969 NA -0.49 -7.36 -0.37 1.47e-12 Superior frontal gyrus grey matter volume; LUSC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs116095464 0.558 rs62346508 chr5:203668 T/C cg22496380 chr5:211416 CCDC127 -0.87 -8.93 -0.44 2.83e-17 Breast cancer; LUSC cis rs6964587 0.967 rs1978061 chr7:91779242 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.89 0.31 9.34e-9 Breast cancer; LUSC cis rs7592578 0.639 rs13417431 chr2:191293055 A/G cg10560079 chr2:191398806 TMEM194B -0.66 -8.31 -0.41 2.44e-15 Diastolic blood pressure; LUSC trans rs7647973 0.626 rs1463728 chr3:49647404 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.65 -0.39 2.2e-13 Menarche (age at onset); LUSC trans rs12310956 0.532 rs1589903 chr12:33943019 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.54 0.42 4.82e-16 Morning vs. evening chronotype; LUSC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.59 8.87 0.44 4.39e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6089584 0.893 rs2281735 chr20:60582540 T/A cg23262073 chr20:60523788 NA -0.42 -6.18 -0.32 1.9e-9 Body mass index; LUSC cis rs977987 0.806 rs7204984 chr16:75475520 G/C cg03315344 chr16:75512273 CHST6 0.49 9.5 0.46 4.32e-19 Dupuytren's disease; LUSC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg05347473 chr6:146136440 FBXO30 -0.57 -10.02 -0.48 8.1e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs9311676 0.609 rs11925862 chr3:58417927 A/C cg13750441 chr3:58318267 PXK 0.35 6.83 0.35 4.14e-11 Systemic lupus erythematosus; LUSC cis rs722599 0.639 rs2193596 chr14:75234101 A/C cg08847533 chr14:75593920 NEK9 0.46 6.29 0.33 9.7e-10 IgG glycosylation; LUSC cis rs6747952 0.899 rs4663856 chr2:239089624 C/A cg17459225 chr2:239074497 NA 0.34 5.77 0.3 1.86e-8 Mean corpuscular hemoglobin concentration; LUSC cis rs6060960 0.537 rs75351461 chr20:30458612 C/T cg06102403 chr20:30458708 TTLL9;DUSP15 0.43 5.73 0.3 2.21e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg24060327 chr5:131705240 SLC22A5 -0.45 -7.53 -0.38 4.85e-13 Blood metabolite levels; LUSC cis rs1322512 0.677 rs1405692 chr6:152937057 G/A cg27316956 chr6:152958899 SYNE1 -0.36 -5.94 -0.31 7.06e-9 Tonometry; LUSC cis rs1506636 1.000 rs635072 chr7:123403255 G/A cg03229431 chr7:123269106 ASB15 0.65 10.7 0.51 3.69e-23 Plateletcrit;Platelet count; LUSC trans rs11098499 0.821 rs28665282 chr4:120384186 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.14e-9 Corneal astigmatism; LUSC cis rs3771570 1.000 rs62193221 chr2:242354632 T/C cg21155796 chr2:242212141 HDLBP 0.62 6.83 0.35 4.12e-11 Prostate cancer; LUSC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg03676636 chr4:99064102 C4orf37 0.35 7.57 0.38 3.67e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7597155 0.935 rs7563401 chr2:69980193 C/T cg02498382 chr2:70120550 SNRNP27 -0.25 -5.87 -0.31 1.03e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2898290 0.622 rs4840567 chr8:11347625 A/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.89 -0.35 2.79e-11 Systolic blood pressure; LUSC cis rs9322193 0.887 rs4870139 chr6:149896318 T/C cg05861140 chr6:150128134 PCMT1 -0.38 -5.85 -0.3 1.17e-8 Lung cancer; LUSC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs1691799 0.899 rs1168305 chr12:66738714 A/G cg16791601 chr12:66731901 HELB -0.73 -12.85 -0.58 5.45e-31 White blood cell count (basophil); LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg14668821 chr17:77704760 ENPP7 0.29 6.07 0.32 3.45e-9 Menopause (age at onset); LUSC trans rs2834506 0.521 rs2243982 chr21:35901290 C/T cg00397714 chr2:192815005 TMEFF2 0.34 6.15 0.32 2.19e-9 Cancer; LUSC cis rs7428496 0.510 rs13093304 chr3:142318911 G/A cg16271453 chr3:142027066 XRN1 -0.48 -8.1 -0.41 1.07e-14 Mean corpuscular hemoglobin; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17461666 chr22:50946709 NCAPH2;LMF2 -0.44 -6.1 -0.32 2.86e-9 Electrocardiographic conduction measures; LUSC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg04369109 chr6:150039330 LATS1 -0.57 -8.3 -0.41 2.62e-15 Lung cancer; LUSC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 10.59 0.5 8.51e-23 Alzheimer's disease; LUSC cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.73 6.79 0.35 5.25e-11 Lung cancer in ever smokers; LUSC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.88 0.48 2.38e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs921968 0.541 rs6720403 chr2:219294258 A/C cg02176678 chr2:219576539 TTLL4 -0.72 -13.29 -0.59 1.23e-32 Mean corpuscular hemoglobin concentration; LUSC cis rs3862435 0.706 rs2589947 chr15:90949177 G/A cg22089800 chr15:90895588 ZNF774 0.55 5.96 0.31 6.34e-9 Response to exercise (triglyceride level interaction); LUSC cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg20887711 chr4:1340912 KIAA1530 0.41 6.26 0.32 1.18e-9 Obesity-related traits; LUSC cis rs8078723 0.714 rs12940405 chr17:38143768 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.46 7.52 0.38 5.02e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg03806693 chr22:41940476 POLR3H -1.06 -15.45 -0.65 5.36e-41 Vitiligo; LUSC cis rs4704187 0.687 rs1422699 chr5:74442410 G/A cg03227963 chr5:74354835 NA 0.31 6.77 0.35 5.75e-11 Response to amphetamines; LUSC cis rs7833986 0.534 rs72653928 chr8:56907735 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.69 10.96 0.51 4.53e-24 Height; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22438603 chr5:127418940 SLC12A2;FLJ33630 -0.37 -6.01 -0.31 4.87e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg16049864 chr8:95962084 TP53INP1 0.59 9.95 0.48 1.3e-20 Type 2 diabetes; LUSC cis rs11098499 0.866 rs10518329 chr4:120401835 A/G cg24375607 chr4:120327624 NA 0.67 10.61 0.5 7.48e-23 Corneal astigmatism; LUSC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg17252645 chr8:143867129 LY6D 0.38 6.72 0.34 8.03e-11 Urinary tract infection frequency; LUSC trans rs35110281 0.743 rs2329443 chr21:45059431 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.68 11.89 0.55 1.92e-27 Mean corpuscular volume; LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg27284194 chr4:1044797 NA 0.34 5.74 0.3 2.17e-8 Obesity-related traits; LUSC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg00033643 chr7:134001901 SLC35B4 0.46 7.24 0.37 3.13e-12 Mean platelet volume; LUSC cis rs9325144 0.647 rs1386018 chr12:39104360 C/T cg13010199 chr12:38710504 ALG10B -0.52 -7.94 -0.4 3.03e-14 Morning vs. evening chronotype; LUSC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg16743903 chr16:89593216 SPG7 -0.41 -5.67 -0.3 3.06e-8 Multiple myeloma (IgH translocation); LUSC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs77633900 0.614 rs2468116 chr15:76870998 G/A cg21673338 chr15:77095150 SCAPER -0.74 -7.29 -0.37 2.29e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg17294928 chr15:75287854 SCAMP5 -0.93 -13.54 -0.6 1.36e-33 Blood trace element (Zn levels); LUSC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg11062466 chr8:58055876 NA 0.71 8.6 0.43 3.25e-16 Developmental language disorder (linguistic errors); LUSC cis rs950776 0.518 rs12900783 chr15:78815523 G/A cg22563815 chr15:78856949 CHRNA5 0.26 6.31 0.33 8.74e-10 Sudden cardiac arrest; LUSC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg02221750 chr19:17393354 ANKLE1 -0.89 -14.15 -0.61 6.29e-36 Systemic lupus erythematosus; LUSC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg18402987 chr7:1209562 NA 0.62 7.17 0.37 4.99e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1044826 0.642 rs295482 chr3:139229264 A/T cg00490450 chr3:139108681 COPB2 -0.46 -7.08 -0.36 8.77e-12 Obesity-related traits; LUSC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg20243544 chr17:37824526 PNMT -0.38 -5.68 -0.3 2.96e-8 Self-reported allergy; LUSC cis rs854765 0.547 rs2955385 chr17:17939247 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.82 15.21 0.64 4.56e-40 Total body bone mineral density; LUSC cis rs4654899 0.897 rs6670897 chr1:21066376 T/C cg01072550 chr1:21505969 NA -0.47 -7.06 -0.36 9.47e-12 Superior frontal gyrus grey matter volume; LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg13560548 chr3:10150139 C3orf24 0.51 7.32 0.37 1.85e-12 Alzheimer's disease; LUSC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg22800045 chr5:56110881 MAP3K1 0.82 10.3 0.49 8.69e-22 Type 2 diabetes; LUSC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg21028142 chr17:79581711 NPLOC4 -0.33 -7.69 -0.39 1.69e-13 Eye color traits; LUSC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg07936489 chr17:37558343 FBXL20 0.72 10.05 0.48 5.95e-21 Glomerular filtration rate (creatinine); LUSC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg19717773 chr7:2847554 GNA12 -0.41 -6.34 -0.33 7.36e-10 Height; LUSC cis rs12950390 0.893 rs4239166 chr17:45847329 A/G cg03474202 chr17:45855739 NA -0.29 -6.52 -0.34 2.58e-10 IgG glycosylation; LUSC cis rs9910055 0.659 rs227584 chr17:42225547 A/C cg09913183 chr17:42254507 C17orf65;ASB16 0.58 9.2 0.45 4.06e-18 Total body bone mineral density; LUSC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg18306943 chr3:40428807 ENTPD3 0.37 5.76 0.3 1.89e-8 Renal cell carcinoma; LUSC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.6 -0.38 3.01e-13 Joint mobility (Beighton score); LUSC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg01125463 chr6:42946178 PEX6 -0.36 -6.14 -0.32 2.39e-9 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs2797160 1.000 rs2747719 chr6:126009214 C/T cg05901451 chr6:126070800 HEY2 0.57 8.54 0.42 4.71e-16 Endometrial cancer; LUSC cis rs9534288 0.913 rs9534298 chr13:46625566 C/G cg15192986 chr13:46630673 CPB2 -0.73 -11.17 -0.52 8.18e-25 Blood protein levels; LUSC cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -8.49 -0.42 6.68e-16 Chronic sinus infection; LUSC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg11764359 chr7:65958608 NA 0.52 6.7 0.34 8.95e-11 Aortic root size; LUSC cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg18252515 chr7:66147081 NA -1.25 -14.44 -0.62 4.77e-37 Gout; LUSC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.53 0.42 5.04e-16 Prudent dietary pattern; LUSC cis rs709400 0.628 rs11622356 chr14:103912195 C/T cg10523860 chr14:103875565 MARK3 -0.37 -5.68 -0.3 2.93e-8 Body mass index; LUSC cis rs208520 1.000 rs12216109 chr6:66987488 C/G cg07460842 chr6:66804631 NA 0.92 12.13 0.55 2.65e-28 Exhaled nitric oxide output; LUSC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg00049323 chr5:472564 LOC25845 -0.43 -6.38 -0.33 5.77e-10 Cystic fibrosis severity; LUSC cis rs7927592 0.546 rs599083 chr11:68192346 T/G cg16797656 chr11:68205561 LRP5 0.45 7.81 0.39 7.47e-14 Total body bone mineral density; LUSC cis rs9457247 0.902 rs366938 chr6:167403538 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.13e-11 Crohn's disease; LUSC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1298908 0.639 rs2236568 chr10:82035923 C/A cg01528321 chr10:82214614 TSPAN14 0.59 8.59 0.43 3.43e-16 Diabetic kidney disease; LUSC cis rs7759001 0.803 rs6456775 chr6:27345383 G/T cg18711553 chr6:27366782 ZNF391 0.41 5.95 0.31 6.67e-9 Glomerular filtration rate (creatinine); LUSC cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg24812749 chr6:127587940 RNF146 0.92 13.97 0.61 3.03e-35 Breast cancer; LUSC cis rs2067615 0.524 rs1922433 chr12:107077172 A/G cg15890332 chr12:107067104 RFX4 0.36 6.24 0.32 1.35e-9 Heart rate; LUSC trans rs747782 0.582 rs7949865 chr11:48346202 A/C cg03929089 chr4:120376271 NA -0.68 -6.39 -0.33 5.57e-10 Intraocular pressure; LUSC cis rs2758596 0.850 rs2495270 chr1:156181530 A/G cg24450063 chr1:156163899 SLC25A44 1.01 7.93 0.4 3.31e-14 Paclitaxel disposition in epithelial ovarian cancer; LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg26647111 chr11:31128758 NA -0.42 -6.03 -0.31 4.44e-9 Red blood cell count; LUSC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg15557168 chr22:42548783 NA -0.46 -7.05 -0.36 1.02e-11 Schizophrenia; LUSC cis rs2404602 0.735 rs11632222 chr15:76712927 C/G cg23625390 chr15:77176239 SCAPER -0.62 -9.54 -0.46 3.13e-19 Blood metabolite levels; LUSC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg19774624 chr17:42201019 HDAC5 -0.78 -11.81 -0.54 4.03e-27 Total body bone mineral density; LUSC cis rs72634258 0.838 rs10489450 chr1:8079301 C/T cg26816564 chr1:7831052 VAMP3 0.48 6.15 0.32 2.2e-9 Inflammatory bowel disease; LUSC trans rs61931739 0.500 rs11053211 chr12:34464334 T/C cg26384229 chr12:38710491 ALG10B 0.79 13.6 0.6 7.86e-34 Morning vs. evening chronotype; LUSC cis rs34779708 0.966 rs11599606 chr10:35406626 G/A cg03585969 chr10:35415529 CREM 0.62 8.95 0.44 2.59e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7727544 0.582 rs3805681 chr5:131537860 T/G cg14196790 chr5:131705035 SLC22A5 0.42 6.95 0.36 1.87e-11 Blood metabolite levels; LUSC cis rs6964587 0.934 rs7811328 chr7:91720931 A/T cg17063962 chr7:91808500 NA 0.58 9.15 0.45 5.95e-18 Breast cancer; LUSC cis rs7681440 0.874 rs7687945 chr4:90764699 C/T cg20003494 chr4:90757398 SNCA -0.33 -5.71 -0.3 2.5e-8 Dementia with Lewy bodies; LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg22166914 chr1:53195759 ZYG11B -0.41 -6.4 -0.33 5.27e-10 Monocyte count; LUSC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg07701084 chr6:150067640 NUP43 0.57 8.6 0.43 3.17e-16 Lung cancer; LUSC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg06462663 chr19:18546047 ISYNA1 0.5 8.49 0.42 6.92e-16 Breast cancer; LUSC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.510 rs56241316 chr1:152901748 A/G cg25856811 chr1:152973957 SPRR3 -0.38 -6.16 -0.32 2.04e-9 Inflammatory skin disease; LUSC cis rs4980532 1 rs4980532 chr11:63680719 C/T cg12527260 chr11:63683744 RCOR2 0.34 6.85 0.35 3.67e-11 Pulse pressure; LUSC cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg15744005 chr10:104629667 AS3MT -0.32 -6.26 -0.32 1.18e-9 Arsenic metabolism; LUSC trans rs17685 0.593 rs56265719 chr7:75796269 C/T cg19862616 chr7:65841803 NCRNA00174 1.1 18.43 0.71 8.08e-53 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs2637266 0.626 rs2583066 chr10:78555839 T/C cg18941641 chr10:78392320 NA 0.38 7.03 0.36 1.19e-11 Pulmonary function; LUSC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.55 -0.38 4.17e-13 Aortic root size; LUSC trans rs11098499 1.000 rs6849889 chr4:120186348 A/C cg25214090 chr10:38739885 LOC399744 0.47 6.94 0.36 2.11e-11 Corneal astigmatism; LUSC cis rs7618501 1.000 rs34614773 chr3:49753003 T/G cg13072238 chr3:49761600 GMPPB -0.38 -6.33 -0.33 8.04e-10 Intelligence (multi-trait analysis); LUSC cis rs734999 0.588 rs2985859 chr1:2532416 T/C cg18932078 chr1:2524107 MMEL1 -0.33 -7.17 -0.37 4.82e-12 Ulcerative colitis; LUSC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC trans rs2243480 0.901 rs35087093 chr7:65405208 C/T cg10756647 chr7:56101905 PSPH 0.86 8.4 0.42 1.27e-15 Diabetic kidney disease; LUSC cis rs12220238 1.000 rs4320897 chr10:76017732 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 7.22 0.37 3.62e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs1163251 0.902 rs483360 chr1:120200606 C/T cg19096424 chr1:120255104 PHGDH -0.47 -6.34 -0.33 7.41e-10 Blood metabolite levels; LUSC cis rs9905704 0.918 rs11656666 chr17:56929840 A/G cg12560992 chr17:57184187 TRIM37 0.57 8.02 0.4 1.79e-14 Testicular germ cell tumor; LUSC cis rs6714710 0.535 rs3192177 chr2:98354511 G/A cg26665480 chr2:98280029 ACTR1B 0.59 8.05 0.4 1.45e-14 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg14668632 chr7:2872130 GNA12 -0.41 -6.05 -0.31 3.95e-9 Height; LUSC cis rs6547741 0.935 rs2384626 chr2:27773648 A/G cg12559939 chr2:27858050 GPN1 0.39 6.03 0.31 4.3e-9 Oral cavity cancer; LUSC cis rs12575480 0.901 rs6578977 chr11:2101804 C/T cg15541987 chr11:2077307 NA -0.43 -6.25 -0.32 1.22e-9 Pursuit maintenance gain; LUSC cis rs11971779 0.680 rs2355788 chr7:139101897 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs713477 0.935 rs12888181 chr14:55906082 A/C cg04306507 chr14:55594613 LGALS3 -0.29 -5.65 -0.3 3.41e-8 Pediatric bone mineral content (femoral neck); LUSC cis rs9814567 1.000 rs6785027 chr3:134211649 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 14.03 0.61 1.77e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs239198 0.521 rs9377241 chr6:101334265 C/T cg09795085 chr6:101329169 ASCC3 0.43 6.1 0.32 2.97e-9 Menarche (age at onset); LUSC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg16680214 chr1:154839983 KCNN3 -0.52 -9.76 -0.47 5.77e-20 Prostate cancer; LUSC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg19592336 chr6:28129416 ZNF389 0.47 6.2 0.32 1.68e-9 Depression; LUSC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg07414643 chr4:187882934 NA 0.55 10.47 0.5 2.32e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs17030434 1.000 rs10026531 chr4:154727070 C/T cg14289246 chr4:154710475 SFRP2 -0.49 -6.75 -0.35 6.71e-11 Electrocardiographic conduction measures; LUSC trans rs2229238 0.911 rs59239860 chr1:154492107 G/T cg25273160 chr11:56955011 LRRC55 0.32 6.1 0.32 2.87e-9 Coronary heart disease; LUSC cis rs11190604 0.767 rs7090150 chr10:102173446 G/T cg07080220 chr10:102295463 HIF1AN 0.6 7.74 0.39 1.19e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg21856205 chr7:94953877 PON1 -0.36 -5.72 -0.3 2.32e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs10754283 0.967 rs10737708 chr1:90119804 A/G cg21401794 chr1:90099060 LRRC8C 0.61 8.78 0.43 8.66e-17 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg24642439 chr20:33292090 TP53INP2 0.61 9.41 0.46 8.57e-19 Coronary artery disease; LUSC trans rs2797160 0.967 rs2226158 chr6:125995467 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.45 -6.62 -0.34 1.42e-10 Endometrial cancer; LUSC cis rs679087 1.000 rs302315 chr12:29919054 G/C cg14258853 chr12:29935411 TMTC1 -1.0 -17.09 -0.68 1.71e-47 Schizophrenia; LUSC cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg09184832 chr6:79620586 NA -0.44 -7.25 -0.37 2.84e-12 Intelligence (multi-trait analysis); LUSC trans rs911555 0.755 rs975892 chr14:103883349 A/T cg17675199 chr6:35436792 RPL10A 0.44 6.62 0.34 1.46e-10 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg19318889 chr4:1322082 MAEA 0.44 7.02 0.36 1.24e-11 Obesity-related traits; LUSC cis rs3862435 0.571 rs2589950 chr15:90957179 C/T cg22089800 chr15:90895588 ZNF774 0.59 6.42 0.33 4.74e-10 Response to exercise (triglyceride level interaction); LUSC cis rs7267979 0.706 rs6037069 chr20:25234166 C/T cg08601574 chr20:25228251 PYGB 0.46 7.01 0.36 1.29e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9916302 0.706 rs1874226 chr17:37729031 C/T cg07936489 chr17:37558343 FBXL20 0.77 9.39 0.46 9.91e-19 Glomerular filtration rate (creatinine); LUSC cis rs11098499 0.863 rs10013305 chr4:120450424 G/A cg09307838 chr4:120376055 NA 0.73 10.36 0.49 5.62e-22 Corneal astigmatism; LUSC cis rs6840360 0.533 rs13139327 chr4:152728590 A/C cg22705602 chr4:152727874 NA -0.35 -7.54 -0.38 4.51e-13 Intelligence (multi-trait analysis); LUSC cis rs10857712 1.000 rs10857712 chr10:135225666 T/C cg01444801 chr10:135216882 MTG1 -0.49 -6.54 -0.34 2.27e-10 Systemic lupus erythematosus; LUSC cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.65 0.5 5.27e-23 Bladder cancer; LUSC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg05234568 chr11:5960015 NA -0.55 -7.91 -0.4 3.9e-14 DNA methylation (variation); LUSC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg04518342 chr5:131593106 PDLIM4 -0.43 -7.38 -0.37 1.29e-12 Breast cancer; LUSC cis rs4595586 0.525 rs7970652 chr12:39374873 T/C cg26384229 chr12:38710491 ALG10B 0.49 6.99 0.36 1.51e-11 Morning vs. evening chronotype; LUSC cis rs2652834 1.000 rs2729781 chr15:63404265 T/A cg05507819 chr15:63340323 TPM1 0.67 8.14 0.41 7.84e-15 HDL cholesterol; LUSC cis rs17125944 0.615 rs7151643 chr14:53313661 G/C cg00686598 chr14:53173677 PSMC6 -0.62 -5.82 -0.3 1.36e-8 Alzheimer's disease (late onset); LUSC cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Bone mineral density; LUSC cis rs2857891 0.817 rs2857903 chr11:6979378 G/A cg04053776 chr11:6947353 ZNF215 0.41 5.74 0.3 2.16e-8 Response to cytadine analogues (cytosine arabinoside); LUSC trans rs7474896 0.616 rs2505239 chr10:38440765 A/G cg17830980 chr10:43048298 ZNF37B -0.53 -6.2 -0.32 1.67e-9 Obesity (extreme); LUSC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11644478 chr21:40555479 PSMG1 0.95 19.06 0.72 2.54e-55 Cognitive function; LUSC cis rs11229555 0.645 rs12226725 chr11:58246332 G/A cg15696309 chr11:58395628 NA -0.67 -8.1 -0.41 1.02e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1577917 1.000 rs12196037 chr6:86694631 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.83 -0.43 6.2e-17 Response to antipsychotic treatment; LUSC cis rs9790314 0.905 rs6774276 chr3:160941318 C/T cg03342759 chr3:160939853 NMD3 -0.53 -9.03 -0.44 1.37e-17 Morning vs. evening chronotype; LUSC trans rs6952808 0.510 rs13227554 chr7:2048220 G/C cg04565464 chr8:145669602 NFKBIL2 -0.39 -6.61 -0.34 1.51e-10 Bipolar disorder and schizophrenia; LUSC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg08684580 chr7:98029266 BAIAP2L1 -0.41 -7.43 -0.38 9.13e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg18904891 chr8:8559673 CLDN23 -0.4 -5.99 -0.31 5.52e-9 Mood instability; LUSC trans rs11098499 0.644 rs28787668 chr4:120554687 G/A cg25214090 chr10:38739885 LOC399744 0.43 6.54 0.34 2.37e-10 Corneal astigmatism; LUSC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.09 0.48 4.38e-21 Electroencephalogram traits; LUSC cis rs9311676 0.656 rs11915480 chr3:58377159 A/G cg13750441 chr3:58318267 PXK 0.34 6.76 0.35 5.99e-11 Systemic lupus erythematosus; LUSC cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg18681998 chr4:17616180 MED28 0.81 14.8 0.63 1.84e-38 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10186029 0.676 rs12614406 chr2:213955803 A/G cg08319019 chr2:214017104 IKZF2 -0.55 -8.02 -0.4 1.82e-14 Systemic sclerosis; LUSC cis rs1728785 0.901 rs8050289 chr16:68566976 T/A cg02972257 chr16:68554789 NA -0.48 -6.24 -0.32 1.35e-9 Ulcerative colitis; LUSC cis rs614226 1.000 rs1167725 chr12:120968559 A/T cg01236616 chr12:121019343 POP5 1.3 21.73 0.77 6.94e-66 Type 1 diabetes nephropathy; LUSC cis rs9925964 0.933 rs881929 chr16:31079371 G/T cg02466173 chr16:30829666 NA 0.35 6.42 0.33 4.65e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17685 0.753 rs13240404 chr7:75675719 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.52 8.07 0.4 1.27e-14 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7586879 0.929 rs6545807 chr2:25124358 C/T cg01884057 chr2:25150051 NA 0.42 9.1 0.45 8.06e-18 Body mass index; LUSC cis rs7582720 1.000 rs72936309 chr2:204040296 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.55 0.42 4.56e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs4332037 0.707 rs73046323 chr7:1882795 G/A cg10840412 chr1:235813424 GNG4 0.47 6.09 0.32 3.02e-9 Bipolar disorder; LUSC cis rs11250464 0.833 rs2387653 chr10:1407826 A/G cg26394196 chr10:1453818 ADARB2 0.38 6.52 0.34 2.66e-10 Radiation response; LUSC cis rs7759001 0.857 rs6915934 chr6:27367887 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.69 0.3 2.84e-8 Glomerular filtration rate (creatinine); LUSC cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg17366294 chr4:99064904 C4orf37 0.58 9.89 0.48 2.08e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg06784218 chr1:46089804 CCDC17 0.58 11.51 0.53 4.82e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg20295408 chr7:1910781 MAD1L1 -0.48 -6.86 -0.35 3.37e-11 Bipolar disorder and schizophrenia; LUSC cis rs2836633 0.929 rs4514962 chr21:40041753 C/T cg05519781 chr21:40033154 ERG 0.78 13.39 0.59 4.93e-33 Coronary artery disease; LUSC cis rs2486288 0.656 rs11632777 chr15:45551045 C/T cg26924012 chr15:45694286 SPATA5L1 -0.73 -10.8 -0.51 1.62e-23 Glomerular filtration rate; LUSC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21659725 chr3:3221576 CRBN -0.9 -18.4 -0.71 1.05e-52 Intelligence (multi-trait analysis); LUSC cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg11244672 chr19:19639970 YJEFN3 -0.59 -7.3 -0.37 2.1e-12 Bipolar disorder; LUSC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg00033643 chr7:134001901 SLC35B4 0.46 7.27 0.37 2.64e-12 Mean platelet volume; LUSC cis rs8062405 0.755 rs17640009 chr16:28595700 A/G cg07382826 chr16:28625726 SULT1A1 0.26 5.69 0.3 2.79e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg06238570 chr21:40685208 BRWD1 0.53 8.43 0.42 1.07e-15 Cognitive function; LUSC cis rs3892630 0.757 rs8109823 chr19:33183316 A/G cg22980127 chr19:33182716 NUDT19 0.95 12.94 0.58 2.44e-31 Red blood cell traits; LUSC cis rs7759001 0.857 rs9468117 chr6:27366862 A/G cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg24642439 chr20:33292090 TP53INP2 0.49 7.34 0.37 1.62e-12 Glomerular filtration rate (creatinine); LUSC cis rs3096299 0.702 rs2086824 chr16:89471246 G/T cg00750074 chr16:89608354 SPG7 0.43 7.65 0.39 2.13e-13 Multiple myeloma (IgH translocation); LUSC cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg24642439 chr20:33292090 TP53INP2 -0.49 -7.35 -0.37 1.59e-12 Glomerular filtration rate (creatinine); LUSC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg16447950 chr5:562315 NA -0.58 -7.3 -0.37 2.1e-12 Obesity-related traits; LUSC cis rs1355223 0.545 rs7123029 chr11:34874815 G/A cg11058730 chr11:34937778 PDHX;APIP -0.47 -6.69 -0.34 9.51e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11098499 0.908 rs1002152 chr4:120273387 C/A cg24375607 chr4:120327624 NA 0.76 11.35 0.53 1.77e-25 Corneal astigmatism; LUSC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg04369109 chr6:150039330 LATS1 -0.58 -8.62 -0.43 2.74e-16 Lung cancer; LUSC cis rs17102423 0.806 rs4902362 chr14:65582755 G/A cg11161011 chr14:65562177 MAX 0.59 9.16 0.45 5.35e-18 Obesity-related traits; LUSC cis rs3741151 0.686 rs1938777 chr11:73122340 A/G cg17517138 chr11:73019481 ARHGEF17 0.79 7.32 0.37 1.86e-12 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC trans rs61931739 0.817 rs1705772 chr12:34174756 G/A cg13010199 chr12:38710504 ALG10B 0.41 6.49 0.33 3.17e-10 Morning vs. evening chronotype; LUSC cis rs3849570 0.925 rs1464791 chr3:81893929 A/C cg07356753 chr3:81810745 GBE1 0.64 10.43 0.5 3.08e-22 Waist circumference;Body mass index; LUSC trans rs656319 0.559 rs17689289 chr8:9977980 C/G cg21775007 chr8:11205619 TDH 0.43 5.98 0.31 5.66e-9 Myopia (pathological); LUSC cis rs34779708 0.931 rs72789687 chr10:35372489 G/A cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs136211 0.662 rs9607338 chr22:36759026 C/T cg16924664 chr22:36878180 TXN2 0.41 6.06 0.31 3.64e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2302777 0.507 rs9889716 chr17:38108298 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -9.19 -0.45 4.25e-18 Multiple myeloma (hyperdiploidy); LUSC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.68 0.34 9.88e-11 Systemic lupus erythematosus; LUSC cis rs8017423 0.647 rs4904680 chr14:90822075 C/T cg04374321 chr14:90722782 PSMC1 -0.43 -6.49 -0.33 3.11e-10 Mortality in heart failure; LUSC cis rs2455601 0.786 rs3763914 chr11:8940703 G/T cg09997546 chr11:8931473 C11orf17;ST5 -0.48 -7.76 -0.39 1.05e-13 Schizophrenia; LUSC cis rs7599312 0.534 rs7355673 chr2:213404389 T/C cg20637307 chr2:213403960 ERBB4 0.44 7.51 0.38 5.38e-13 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg24642439 chr20:33292090 TP53INP2 0.41 6.02 0.31 4.57e-9 Glomerular filtration rate (creatinine); LUSC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg01879757 chr17:41196368 BRCA1 -0.48 -7.29 -0.37 2.23e-12 Menopause (age at onset); LUSC cis rs6696846 0.749 rs11578293 chr1:205070178 T/C cg21643547 chr1:205240462 TMCC2 -0.38 -7.17 -0.37 4.92e-12 Red blood cell count; LUSC cis rs6977660 0.714 rs12672257 chr7:19813466 C/T cg07541023 chr7:19748670 TWISTNB 0.65 7.05 0.36 1.02e-11 Thyroid stimulating hormone; LUSC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg22535103 chr8:58192502 C8orf71 0.59 7.07 0.36 9e-12 Developmental language disorder (linguistic errors); LUSC cis rs2742417 0.603 rs9826208 chr3:45773991 C/T cg04837898 chr3:45731254 SACM1L -0.45 -7.25 -0.37 2.97e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs909002 1.000 rs909002 chr1:32139635 C/T cg13919466 chr1:32135498 COL16A1 -0.37 -6.9 -0.35 2.57e-11 Intelligence (multi-trait analysis); LUSC cis rs981844 0.712 rs4538465 chr4:154746763 T/C cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 0.69 11.55 0.53 3.53e-26 Systemic lupus erythematosus; LUSC cis rs2692947 0.644 rs1168974 chr2:96814928 G/A cg22654517 chr2:96458247 NA 0.32 5.86 0.31 1.08e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9788721 0.967 rs2036527 chr15:78851615 G/A cg18825076 chr15:78729989 IREB2 -0.47 -7.12 -0.36 6.68e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.55 0.42 4.57e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8038465 0.615 rs4075802 chr15:73963239 A/G cg15420318 chr15:73925796 NPTN 0.62 10.76 0.51 2.22e-23 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs941408 1.000 rs1076447 chr19:2792128 C/G cg22153745 chr1:153894579 GATAD2B -0.54 -8.2 -0.41 5.23e-15 Total cholesterol levels; LUSC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.54 -9.3 -0.45 1.92e-18 Prudent dietary pattern; LUSC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg20607798 chr8:58055168 NA 0.5 6.03 0.31 4.35e-9 Developmental language disorder (linguistic errors); LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg16393715 chr7:1948819 MAD1L1 0.34 5.82 0.3 1.35e-8 Bipolar disorder and schizophrenia; LUSC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg17376030 chr22:41985996 PMM1 -0.46 -5.72 -0.3 2.42e-8 Vitiligo; LUSC cis rs7959452 0.570 rs10878964 chr12:69720691 T/G cg14784868 chr12:69753453 YEATS4 0.63 9.41 0.46 8.13e-19 Blood protein levels; LUSC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg04553112 chr3:125709451 NA -0.5 -5.7 -0.3 2.7e-8 Blood pressure (smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05862135 chr16:3074294 HCFC1R1;THOC6 -0.4 -5.96 -0.31 6.27e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs977987 0.806 rs1109342 chr16:75445675 A/G cg04384234 chr16:75411784 CFDP1 0.4 6.47 0.33 3.45e-10 Dupuytren's disease; LUSC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg23172400 chr8:95962367 TP53INP1 -0.38 -7.72 -0.39 1.35e-13 Type 2 diabetes; LUSC cis rs11098499 0.955 rs7684942 chr4:120162201 C/T cg24375607 chr4:120327624 NA 0.76 11.59 0.54 2.52e-26 Corneal astigmatism; LUSC trans rs9380880 0.826 rs9380882 chr6:39547428 A/T cg14673904 chr12:46609063 SLC38A1 0.54 5.99 0.31 5.41e-9 Immune response to smallpox vaccine (IL-6); LUSC cis rs2050392 0.517 rs160017 chr10:30772894 A/G cg25182066 chr10:30743637 MAP3K8 -0.46 -6.7 -0.34 8.71e-11 Inflammatory bowel disease; LUSC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg15147215 chr3:52552868 STAB1 -0.3 -5.92 -0.31 8e-9 Electroencephalogram traits; LUSC cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg27279351 chr12:120934652 DYNLL1 0.62 8.23 0.41 4.34e-15 High light scatter reticulocyte count; LUSC cis rs7582180 0.629 rs11688285 chr2:100948054 A/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.55 -0.42 4.59e-16 Intelligence (multi-trait analysis); LUSC trans rs7746199 0.673 rs72845046 chr6:27575268 T/A cg06606381 chr12:133084897 FBRSL1 -0.97 -8.98 -0.44 1.96e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs11098499 0.863 rs11098531 chr4:120465001 G/A cg24375607 chr4:120327624 NA 0.76 11.3 0.53 2.66e-25 Corneal astigmatism; LUSC cis rs6545883 0.759 rs777585 chr2:61412559 A/G cg15711740 chr2:61764176 XPO1 0.4 6.05 0.31 3.9e-9 Tuberculosis; LUSC cis rs57590327 0.508 rs13093082 chr3:81949958 C/T cg07356753 chr3:81810745 GBE1 -0.59 -8.68 -0.43 1.79e-16 Extraversion; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg22092082 chr2:191184568 HIBCH 0.41 6.08 0.32 3.24e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7945705 0.791 rs4579928 chr11:8815704 A/G cg12365402 chr11:9010492 NRIP3 0.43 7.87 0.4 4.92e-14 Hemoglobin concentration; LUSC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg22834771 chr12:69754056 YEATS4 -0.51 -7.51 -0.38 5.36e-13 Blood protein levels; LUSC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg12927641 chr6:109611667 NA -0.35 -5.87 -0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.71 -9.55 -0.46 2.88e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg13560548 chr3:10150139 C3orf24 0.53 6.84 0.35 3.75e-11 Alzheimer's disease; LUSC cis rs9427116 0.502 rs9427100 chr1:154583762 G/A cg17218026 chr1:154582156 ADAR 0.56 9.99 0.48 9.98e-21 Blood protein levels; LUSC cis rs2070488 0.761 rs6807940 chr3:38460062 C/G cg24069376 chr3:38537580 EXOG 0.34 6.51 0.34 2.83e-10 Electrocardiographic conduction measures; LUSC cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg17264618 chr3:40429014 ENTPD3 0.34 7.22 0.37 3.62e-12 Renal cell carcinoma; LUSC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg12463550 chr7:65579703 CRCP 0.46 6.61 0.34 1.5e-10 Aortic root size; LUSC cis rs929354 0.772 rs3802125 chr7:156970563 A/C cg17757837 chr7:157058334 UBE3C 0.83 13.15 0.58 4.02e-32 Body mass index; LUSC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg06008330 chr7:65541103 ASL -0.36 -5.71 -0.3 2.54e-8 Aortic root size; LUSC cis rs12594515 1.000 rs12595137 chr15:45986105 G/T cg19682013 chr15:45996608 NA 0.38 5.75 0.3 2.03e-8 Waist circumference;Weight; LUSC cis rs2692947 0.727 rs749457 chr2:96795944 A/G cg23100626 chr2:96804247 ASTL 0.26 6.57 0.34 1.96e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs524023 1.000 rs505802 chr11:64357072 T/C cg07220939 chr11:64358617 SLC22A12 0.23 6.04 0.31 4.18e-9 Urate levels in obese individuals; LUSC cis rs10170846 0.861 rs4674677 chr2:223529658 G/A cg25565276 chr2:223520875 FARSB 0.66 9.98 0.48 1.05e-20 Schizophrenia (inflammation and infection response interaction); LUSC cis rs7592578 0.766 rs62181052 chr2:191387858 A/G cg11845111 chr2:191398756 TMEM194B -0.91 -10.78 -0.51 1.9e-23 Diastolic blood pressure; LUSC cis rs17608059 0.710 rs8080167 chr17:13949828 G/A cg27005118 chr17:13972210 COX10 -0.45 -8.59 -0.43 3.45e-16 Temperament; LUSC cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.7e-16 Menopause (age at onset); LUSC cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg10978503 chr1:24200527 CNR2 0.53 12.98 0.58 1.85e-31 Immature fraction of reticulocytes; LUSC cis rs12474201 0.862 rs13025595 chr2:46977893 A/G cg06386533 chr2:46925753 SOCS5 0.66 9.71 0.47 8.4e-20 Height; LUSC cis rs2857891 0.817 rs2638095 chr11:6979915 C/T cg14883916 chr11:6947541 ZNF215 0.45 5.83 0.3 1.3e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs1775715 0.513 rs2808089 chr10:32145112 A/T cg03015672 chr10:32216066 ARHGAP12 0.35 6.36 0.33 6.52e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs501916 0.575 rs56345741 chr15:48065010 A/C cg16110827 chr15:48056943 SEMA6D -0.39 -6.14 -0.32 2.38e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.49e-11 Schizophrenia; LUSC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6960043 1.000 rs6972333 chr7:15051643 G/A cg19272540 chr7:15055459 NA -0.31 -7.34 -0.37 1.61e-12 Type 2 diabetes; LUSC cis rs3764563 0.935 rs10408443 chr19:15715973 C/T cg20725493 chr19:15740067 CYP4F8 -0.67 -6.55 -0.34 2.2e-10 Inflammatory biomarkers; LUSC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg04369109 chr6:150039330 LATS1 -0.53 -7.73 -0.39 1.24e-13 Lung cancer; LUSC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg12463550 chr7:65579703 CRCP -0.51 -7.33 -0.37 1.74e-12 Aortic root size; LUSC cis rs6121246 0.697 rs6088857 chr20:30226764 G/C cg18721089 chr20:30220636 NA -0.41 -6.76 -0.35 6.18e-11 Mean corpuscular hemoglobin; LUSC cis rs2295359 0.963 rs12030867 chr1:67627620 T/C cg03340356 chr1:67600835 NA 0.42 6.71 0.34 8.14e-11 Psoriasis; LUSC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg25566285 chr7:158114605 PTPRN2 -0.33 -6.06 -0.31 3.61e-9 Calcium levels; LUSC cis rs617219 0.889 rs1664551 chr5:78440096 C/T cg24856658 chr5:78533917 JMY -0.3 -5.68 -0.3 3e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg03806693 chr22:41940476 POLR3H 1.0 14.26 0.62 2.38e-36 Vitiligo; LUSC cis rs73416724 1.000 rs76658194 chr6:43357601 C/T cg26312998 chr6:43337775 ZNF318 0.56 6.68 0.34 1.02e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs61931739 0.500 rs7979482 chr12:34542877 C/A cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.26e-41 Morning vs. evening chronotype; LUSC cis rs1775715 0.835 rs1419169 chr10:32257204 C/G cg03015672 chr10:32216066 ARHGAP12 0.33 5.7 0.3 2.58e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg26677194 chr12:130822605 PIWIL1 0.59 8.78 0.43 8.41e-17 Menopause (age at onset); LUSC cis rs2404602 0.647 rs11072628 chr15:77107761 C/A cg23625390 chr15:77176239 SCAPER -0.65 -9.76 -0.47 6e-20 Blood metabolite levels; LUSC cis rs10089 1.000 rs17164310 chr5:127493679 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.85 10.94 0.51 4.98e-24 Ileal carcinoids; LUSC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg24060327 chr5:131705240 SLC22A5 -0.5 -8.53 -0.42 5.3e-16 Breast cancer; LUSC cis rs10193935 1.000 rs13411405 chr2:42413811 C/A cg27598129 chr2:42591480 NA -0.61 -8.05 -0.4 1.48e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs17621444 0.522 rs4611122 chr10:121809472 G/A cg02041677 chr10:121771263 NA -0.34 -6.31 -0.33 8.87e-10 IgG glycosylation; LUSC cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg06550200 chr5:1325588 CLPTM1L -0.67 -11.71 -0.54 8.94e-27 Lung cancer; LUSC cis rs9309473 0.579 rs1852644 chr2:73597718 A/G cg20560298 chr2:73613845 ALMS1 -0.53 -7.81 -0.39 7.72e-14 Metabolite levels; LUSC cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg06784218 chr1:46089804 CCDC17 -0.51 -9.86 -0.47 2.72e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg26380479 chr7:97908229 NA -0.27 -6.05 -0.31 3.86e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg22875332 chr1:76189707 ACADM -0.74 -10.26 -0.49 1.15e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10435719 0.899 rs9329251 chr8:11793606 G/A cg21775007 chr8:11205619 TDH 0.47 6.67 0.34 1.09e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs12908161 0.515 rs12907646 chr15:85403496 G/A cg12863693 chr15:85201151 NMB 0.32 5.93 0.31 7.41e-9 Schizophrenia; LUSC cis rs72781680 0.898 rs72780118 chr2:23994431 G/A cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs3806843 0.966 rs11958868 chr5:140201420 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.77 -0.3 1.79e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs3540 0.533 rs4932342 chr15:90982923 C/T cg10434728 chr15:90938212 IQGAP1 0.41 8.39 0.42 1.42e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg08470875 chr2:26401718 FAM59B -0.68 -9.09 -0.45 9.26e-18 Gut microbiome composition (summer); LUSC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg05855489 chr10:104503620 C10orf26 0.57 8.5 0.42 6.2e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs877282 0.945 rs34367686 chr10:791868 G/C cg13042288 chr15:90349979 ANPEP -0.47 -6.7 -0.34 8.67e-11 Uric acid levels; LUSC cis rs1577917 0.958 rs12196175 chr6:86779370 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.46 -0.42 8.72e-16 Response to antipsychotic treatment; LUSC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg04865166 chr7:105162814 PUS7 0.51 5.67 0.3 3.06e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9283706 0.608 rs12523505 chr5:66334631 C/T cg11590213 chr5:66331682 MAST4 0.44 6.42 0.33 4.75e-10 Coronary artery disease; LUSC cis rs9329221 0.662 rs34155841 chr8:10247529 T/G cg27411982 chr8:10470053 RP1L1 0.41 5.84 0.3 1.25e-8 Neuroticism; LUSC cis rs614226 1.000 rs580016 chr12:120933977 T/C cg27489772 chr12:121021490 NA -0.53 -6.84 -0.35 3.8e-11 Type 1 diabetes nephropathy; LUSC cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg05234568 chr11:5960015 NA -0.65 -9.51 -0.46 3.76e-19 DNA methylation (variation); LUSC cis rs735396 1.000 rs1169310 chr12:121439433 G/A cg02403541 chr12:121454288 C12orf43 0.59 8.45 0.42 8.98e-16 N-glycan levels; LUSC cis rs7043114 0.507 rs7037075 chr9:95216613 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.37 -6.65 -0.34 1.18e-10 Height; LUSC cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg23711669 chr6:146136114 FBXO30 0.84 15.9 0.66 8.58e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg05025164 chr4:1340916 KIAA1530 0.47 7.46 0.38 7.56e-13 Longevity; LUSC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs72674100 1.000 rs2002117 chr4:97992122 C/T cg09670535 chr1:18959427 PAX7 -0.63 -6.48 -0.33 3.21e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs12049351 0.774 rs12125125 chr1:229627666 A/T cg11742688 chr1:229674241 ABCB10 -0.4 -5.68 -0.3 2.96e-8 Circulating myeloperoxidase levels (plasma); LUSC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs6429082 0.668 rs291395 chr1:235652049 A/C cg26050004 chr1:235667680 B3GALNT2 -0.64 -10.43 -0.5 3.09e-22 Adiposity; LUSC cis rs3858526 0.834 rs10838989 chr11:5978057 A/G cg02574844 chr11:5959923 NA -0.45 -6.26 -0.32 1.2e-9 DNA methylation (variation); LUSC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg09263875 chr16:632152 PIGQ 0.72 13.42 0.59 3.71e-33 Height; LUSC cis rs478304 0.619 rs10896028 chr11:65432187 A/T cg27068330 chr11:65405492 SIPA1 -0.75 -10.43 -0.5 3.02e-22 Acne (severe); LUSC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg06001716 chr17:41278141 BRCA1;NBR2 -0.35 -5.79 -0.3 1.62e-8 Menopause (age at onset); LUSC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg26270066 chr15:43941407 CATSPER2 -0.68 -6.12 -0.32 2.57e-9 Myocardial infarction; LUSC cis rs2898290 0.622 rs1382567 chr8:11350899 T/C cg21775007 chr8:11205619 TDH -0.47 -7.01 -0.36 1.35e-11 Systolic blood pressure; LUSC cis rs8062405 0.755 rs12445823 chr16:28588049 A/C cg07382826 chr16:28625726 SULT1A1 0.28 5.97 0.31 5.93e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs853679 1.000 rs853678 chr6:28297313 T/A cg06606381 chr12:133084897 FBRSL1 -0.58 -6.44 -0.33 4.25e-10 Depression; LUSC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg16524733 chr11:117070046 TAGLN 0.36 5.74 0.3 2.16e-8 Blood protein levels; LUSC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg18351406 chr4:77819688 ANKRD56 0.58 8.49 0.42 7.11e-16 Emphysema distribution in smoking; LUSC cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs637571 0.522 rs7105628 chr11:65763067 C/T cg17712092 chr4:129076599 LARP1B 0.8 12.19 0.55 1.53e-28 Eosinophil percentage of white cells; LUSC cis rs9341808 0.754 rs9352817 chr6:81025879 T/G cg08355045 chr6:80787529 NA 0.56 9.99 0.48 9.78e-21 Sitting height ratio; LUSC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg19592336 chr6:28129416 ZNF389 0.47 6.19 0.32 1.75e-9 Depression; LUSC cis rs9527 1.000 rs4919690 chr10:104616500 C/T cg04362960 chr10:104952993 NT5C2 -0.6 -8.35 -0.42 1.79e-15 Arsenic metabolism; LUSC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg12257692 chr3:49977190 RBM6 0.26 7.4 0.38 1.1e-12 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg23711669 chr6:146136114 FBXO30 0.9 17.06 0.68 2.3e-47 Lobe attachment (rater-scored or self-reported); LUSC cis rs9399401 0.601 rs171891 chr6:142850612 G/A cg03128060 chr6:142623767 GPR126 0.51 8.0 0.4 2.01e-14 Chronic obstructive pulmonary disease; LUSC trans rs1973993 0.745 rs9437743 chr1:96961723 C/T cg10631902 chr5:14652156 NA 0.44 6.53 0.34 2.43e-10 Weight; LUSC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg10802521 chr3:52805072 NEK4 -0.44 -6.76 -0.35 6.05e-11 Bipolar disorder; LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg04919579 chr3:196230449 RNF168 0.4 6.33 0.33 8.03e-10 Metabolite levels (Pyroglutamine); LUSC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg06287003 chr12:125626642 AACS -0.38 -6.61 -0.34 1.49e-10 Post bronchodilator FEV1/FVC ratio; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg10372701 chr3:142546496 PCOLCE2 -0.36 -6.08 -0.32 3.32e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg19622623 chr12:86230825 RASSF9 -0.44 -6.13 -0.32 2.49e-9 Major depressive disorder; LUSC cis rs7659604 0.537 rs6815973 chr4:122663430 A/T cg19748678 chr4:122722346 EXOSC9 -0.45 -5.76 -0.3 1.88e-8 Type 2 diabetes; LUSC cis rs1018836 0.886 rs10956750 chr8:91621704 G/C cg16814680 chr8:91681699 NA -0.77 -12.95 -0.58 2.23e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg02574844 chr11:5959923 NA 0.46 6.56 0.34 2.09e-10 DNA methylation (variation); LUSC cis rs10779751 0.734 rs2791647 chr1:11132801 G/A cg04508216 chr1:11107452 MASP2 0.31 5.67 0.3 3.17e-8 Body mass index; LUSC cis rs62400317 0.826 rs12205468 chr6:45310285 G/A cg20913747 chr6:44695427 NA -0.47 -7.73 -0.39 1.27e-13 Total body bone mineral density; LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg22166914 chr1:53195759 ZYG11B -0.55 -9.13 -0.45 6.94e-18 Monocyte count; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg11965913 chr1:205819406 PM20D1 0.92 18.64 0.71 1.16e-53 Menarche (age at onset); LUSC cis rs1670533 1.000 rs10031302 chr4:1059664 G/A cg02018176 chr4:1364513 KIAA1530 0.44 6.15 0.32 2.2e-9 Recombination rate (females); LUSC cis rs58785573 0.570 rs1824652 chr4:38644597 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.46 7.1 0.36 7.64e-12 Lymphocyte percentage of white cells; LUSC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg27535305 chr1:53392650 SCP2 -0.49 -9.55 -0.46 2.99e-19 Monocyte count; LUSC cis rs61990749 0.597 rs10142722 chr14:78275549 A/T cg02301378 chr14:78227641 SNW1;C14orf178 0.56 5.97 0.31 6.11e-9 Fibroblast growth factor basic levels; LUSC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg07507251 chr3:52567010 NT5DC2 0.37 7.59 0.38 3.33e-13 Electroencephalogram traits; LUSC cis rs58688157 0.960 rs1055382 chr11:612182 T/C cg01616529 chr11:638424 DRD4 -0.34 -5.98 -0.31 5.7e-9 Systemic lupus erythematosus; LUSC cis rs713587 0.713 rs12618252 chr2:25207950 G/A cg15423357 chr2:25149977 NA -0.37 -7.35 -0.37 1.54e-12 Body mass index in non-asthmatics; LUSC cis rs2879627 0.616 rs1937682 chr10:53678982 A/T cg06976598 chr10:53639124 PRKG1 0.47 5.88 0.31 9.78e-9 Coronary artery disease; LUSC cis rs722599 0.748 rs59112602 chr14:75358817 C/G cg06637938 chr14:75390232 RPS6KL1 -0.41 -6.0 -0.31 5.02e-9 IgG glycosylation; LUSC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.36 0.33 6.81e-10 Tonsillectomy; LUSC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg21918786 chr6:109611834 NA 0.34 5.87 0.31 1.02e-8 Reticulocyte fraction of red cells; LUSC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.51 0.42 5.77e-16 Alzheimer's disease; LUSC cis rs2348418 0.831 rs7296538 chr12:28711783 C/G cg13890972 chr12:28721907 NA 0.35 5.98 0.31 5.65e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs8060686 0.698 rs8044558 chr16:68210165 T/C cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -9.07 -0.44 1.06e-17 Monocyte percentage of white cells; LUSC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg03354898 chr7:1950403 MAD1L1 0.34 6.51 0.34 2.74e-10 Bipolar disorder and schizophrenia; LUSC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg19468946 chr17:37922297 IKZF3 -0.45 -7.0 -0.36 1.45e-11 Self-reported allergy; LUSC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg16405210 chr4:1374714 KIAA1530 -0.54 -8.62 -0.43 2.69e-16 Obesity-related traits; LUSC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg16447950 chr5:562315 NA -0.53 -6.48 -0.33 3.31e-10 Obesity-related traits; LUSC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.04 -0.4 1.62e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7143963 1.000 rs7143963 chr14:103304425 C/T cg21920469 chr14:103375193 NA -0.43 -5.77 -0.3 1.85e-8 Body mass index; LUSC cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg24558204 chr6:135376177 HBS1L 0.68 10.65 0.5 5.53e-23 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs10465746 0.967 rs11163879 chr1:84444051 T/C cg10977910 chr1:84465055 TTLL7 0.42 6.23 0.32 1.42e-9 Obesity-related traits; LUSC cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 1.0 18.78 0.72 3.2e-54 Chronic sinus infection; LUSC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg10802521 chr3:52805072 NEK4 -0.53 -8.57 -0.42 3.89e-16 Bipolar disorder; LUSC cis rs12532214 0.645 rs6973204 chr7:3178561 C/T cg19214707 chr7:3157722 NA 0.37 5.66 0.3 3.19e-8 Itch intensity from mosquito bite; LUSC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg01368799 chr11:117014884 PAFAH1B2 0.66 10.53 0.5 1.4e-22 Blood protein levels; LUSC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg14784868 chr12:69753453 YEATS4 -0.9 -16.15 -0.66 8.73e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs1790761 0.667 rs598811 chr11:67311676 C/T cg00290607 chr11:67383545 NA 0.36 6.62 0.34 1.41e-10 Mean corpuscular volume; LUSC cis rs708547 0.599 rs2948348 chr4:57848772 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.44 -6.54 -0.34 2.34e-10 Response to bleomycin (chromatid breaks); LUSC cis rs7481584 0.624 rs12417389 chr11:3035304 G/C cg05729581 chr11:3078854 CARS 0.42 6.22 0.32 1.51e-9 Calcium levels; LUSC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg15147215 chr3:52552868 STAB1 -0.31 -6.0 -0.31 5.02e-9 Bipolar disorder; LUSC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg23630131 chr7:65973040 NA 0.21 5.78 0.3 1.74e-8 Aortic root size; LUSC cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg21535247 chr6:8435926 SLC35B3 0.58 8.86 0.44 4.72e-17 Motion sickness; LUSC cis rs7223966 1.000 rs16947042 chr17:61766457 T/G cg05941027 chr17:61774174 LIMD2 0.22 5.79 0.3 1.63e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg20295408 chr7:1910781 MAD1L1 -0.52 -7.48 -0.38 6.42e-13 Bipolar disorder and schizophrenia; LUSC cis rs612683 0.735 rs3754131 chr1:100931073 A/C cg06223162 chr1:101003688 GPR88 0.51 9.44 0.46 6.86e-19 Breast cancer; LUSC cis rs1577917 1.000 rs2324843 chr6:86617501 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs2635047 0.904 rs2635046 chr18:44728429 G/A cg19077165 chr18:44547161 KATNAL2 -0.38 -5.74 -0.3 2.14e-8 Educational attainment; LUSC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg09904177 chr6:26538194 HMGN4 0.48 7.59 0.38 3.19e-13 Schizophrenia; LUSC cis rs12579753 0.869 rs17692407 chr12:82171369 G/C cg07988820 chr12:82153109 PPFIA2 -0.44 -6.2 -0.32 1.7e-9 Resting heart rate; LUSC cis rs1775715 0.644 rs2799022 chr10:32137198 C/T cg26784012 chr10:32216390 ARHGAP12 0.47 7.91 0.4 3.89e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs3806933 0.522 rs13153937 chr5:110434307 C/T cg04022379 chr5:110408740 TSLP 0.62 9.39 0.46 9.73e-19 Eosinophilic esophagitis; LUSC cis rs10465746 0.935 rs12758441 chr1:84352034 A/G cg10977910 chr1:84465055 TTLL7 0.44 6.35 0.33 6.92e-10 Obesity-related traits; LUSC cis rs1570884 0.516 rs2146144 chr13:50170245 C/T cg03651054 chr13:50194643 NA 0.36 6.2 0.32 1.71e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs2303282 0.690 rs4783940 chr16:56451482 T/C cg00500540 chr16:56394104 NA -0.43 -7.37 -0.37 1.37e-12 Breast cancer; LUSC cis rs2115630 1.000 rs10220733 chr15:85280864 G/A cg11189052 chr15:85197271 WDR73 -0.45 -6.44 -0.33 4.19e-10 P wave terminal force; LUSC cis rs7786877 0.626 rs11983745 chr7:100223678 T/C cg00334542 chr7:100209784 MOSPD3 -0.67 -7.52 -0.38 5.23e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs926938 0.584 rs360606 chr1:115391769 C/T cg12756093 chr1:115239321 AMPD1 0.54 8.24 0.41 3.86e-15 Autism; LUSC cis rs9929218 0.953 rs34909703 chr16:68740097 T/C cg02972257 chr16:68554789 NA 0.46 5.99 0.31 5.39e-9 Colorectal cancer; LUSC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs12618769 0.625 rs4850877 chr2:99112154 C/T cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs9549367 0.713 rs4907593 chr13:113830459 C/T cg18105134 chr13:113819100 PROZ 0.66 9.88 0.48 2.32e-20 Platelet distribution width; LUSC cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg24812749 chr6:127587940 RNF146 0.92 13.93 0.61 4.14e-35 Breast cancer; LUSC cis rs559928 0.606 rs60394481 chr11:63909035 G/A cg24687543 chr11:63912206 MACROD1 0.47 5.96 0.31 6.34e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg17541715 chr7:1216824 NA -0.37 -5.65 -0.3 3.48e-8 Longevity;Endometriosis; LUSC cis rs6500395 1.000 rs12919520 chr16:48705760 G/C cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg09165964 chr15:75287851 SCAMP5 -1.06 -15.86 -0.66 1.22e-42 Blood trace element (Zn levels); LUSC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg14196790 chr5:131705035 SLC22A5 0.5 8.31 0.41 2.44e-15 Blood metabolite levels; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg21356179 chr17:73974861 C17orf106;ACOX1 0.47 7.2 0.37 3.98e-12 Schizophrenia; LUSC cis rs2070433 0.500 rs2070435 chr21:47961711 C/T cg12379764 chr21:47803548 PCNT 0.71 11.01 0.52 3.03e-24 Lymphocyte counts; LUSC cis rs2857891 0.659 rs2262676 chr11:6996609 T/G cg04053776 chr11:6947353 ZNF215 0.45 6.4 0.33 5.32e-10 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs3812762 0.833 rs10500707 chr11:8817580 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.39 6.48 0.33 3.23e-10 Hypospadias; LUSC trans rs7618501 0.602 rs6780731 chr3:50017478 A/G cg21659725 chr3:3221576 CRBN 0.63 10.31 0.49 8.07e-22 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.817 rs12287396 chr11:49819798 G/C cg03929089 chr4:120376271 NA -1.04 -19.93 -0.74 9.13e-59 Height; LUSC cis rs4803468 1.000 rs2241711 chr19:41911980 T/C cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.41 5.71 0.3 2.43e-8 Height; LUSC cis rs2404602 0.608 rs12911035 chr15:76606591 T/C cg22467129 chr15:76604101 ETFA -0.48 -7.77 -0.39 1e-13 Blood metabolite levels; LUSC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg17143192 chr8:8559678 CLDN23 -0.58 -8.02 -0.4 1.82e-14 Obesity-related traits; LUSC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg14582100 chr15:45693742 SPATA5L1 0.57 10.54 0.5 1.3e-22 Homoarginine levels; LUSC trans rs8072100 0.817 rs11869940 chr17:45578435 T/A cg03886242 chr7:26192032 NFE2L3 0.36 5.95 0.31 6.72e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7267979 0.966 rs4815414 chr20:25361701 A/G cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8114671 0.562 rs2273683 chr20:33509523 C/T cg08999081 chr20:33150536 PIGU 0.33 5.71 0.3 2.54e-8 Height; LUSC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.73 0.35 7.27e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs981844 0.753 rs1105491 chr4:154726634 A/C cg14289246 chr4:154710475 SFRP2 0.45 5.96 0.31 6.24e-9 Response to statins (LDL cholesterol change); LUSC cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs62432291 0.681 rs388001 chr6:159658459 C/T cg14500486 chr6:159655392 FNDC1 -0.54 -6.06 -0.31 3.76e-9 Joint mobility (Beighton score); LUSC cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg27129171 chr3:47204927 SETD2 0.52 7.52 0.38 4.98e-13 Birth weight; LUSC cis rs4654899 0.865 rs61779120 chr1:21481230 T/C cg02927042 chr1:21476669 EIF4G3 -0.41 -6.51 -0.34 2.71e-10 Superior frontal gyrus grey matter volume; LUSC cis rs7666738 0.519 rs13136069 chr4:98819568 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.01 0.44 1.68e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg25427524 chr10:38739819 LOC399744 -0.74 -14.04 -0.61 1.56e-35 Extrinsic epigenetic age acceleration; LUSC cis rs4808199 0.649 rs12983940 chr19:19516431 G/A cg03709012 chr19:19516395 GATAD2A 1.16 15.43 0.65 6.01e-41 Nonalcoholic fatty liver disease; LUSC cis rs41308713 0.681 rs8116426 chr20:37034643 A/C cg09132763 chr20:37064059 LOC388796;SNORA71D 1.0 6.87 0.35 3.1e-11 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs4662945 0.504 rs35568023 chr2:130251812 A/T cg05962382 chr2:130345044 NA -0.35 -6.16 -0.32 2.04e-9 Response to cytidine analogues (gemcitabine); LUSC trans rs330048 0.545 rs11781008 chr8:9153239 G/T cg15556689 chr8:8085844 FLJ10661 0.5 6.94 0.36 2.11e-11 Systemic lupus erythematosus; LUSC cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg03354898 chr7:1950403 MAD1L1 -0.34 -6.9 -0.35 2.62e-11 Bipolar disorder and schizophrenia; LUSC cis rs4319547 0.656 rs9788145 chr12:122899522 C/T cg23029597 chr12:123009494 RSRC2 -0.71 -9.06 -0.44 1.15e-17 Body mass index; LUSC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg10755058 chr3:40428713 ENTPD3 0.35 5.76 0.3 1.89e-8 Renal cell carcinoma; LUSC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -5.98 -0.31 5.61e-9 Tonsillectomy; LUSC cis rs1983891 1.000 rs6458228 chr6:41543793 C/A cg15051332 chr6:41514432 FOXP4 0.41 5.91 0.31 8.43e-9 Prostate cancer; LUSC cis rs7829975 0.684 rs488904 chr8:8587571 T/G cg15556689 chr8:8085844 FLJ10661 -0.56 -8.46 -0.42 8.39e-16 Mood instability; LUSC cis rs2486288 0.656 rs9921035 chr15:45546660 C/T cg26924012 chr15:45694286 SPATA5L1 -0.69 -10.04 -0.48 6.57e-21 Glomerular filtration rate; LUSC cis rs5769707 0.935 rs5770594 chr22:50018497 G/A cg07959070 chr22:50026188 C22orf34 -0.36 -7.39 -0.37 1.18e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg18758796 chr5:131593413 PDLIM4 0.41 6.72 0.34 8.02e-11 Breast cancer; LUSC cis rs62400317 0.859 rs55964727 chr6:45259079 A/C cg18551225 chr6:44695536 NA -0.42 -7.08 -0.36 8.7e-12 Total body bone mineral density; LUSC cis rs6489785 0.509 rs3213570 chr12:121222411 C/G cg02419362 chr12:121203948 SPPL3 0.46 8.48 0.42 7.16e-16 Longevity;Allergic disease (asthma, hay fever or eczema); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01447244 chr15:90931524 IQGAP1 -0.4 -6.12 -0.32 2.63e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.61 8.88 0.44 4.31e-17 Alzheimer's disease; LUSC cis rs2637266 0.783 rs12258504 chr10:78477055 C/T cg18941641 chr10:78392320 NA 0.34 6.22 0.32 1.52e-9 Pulmonary function; LUSC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg03188948 chr7:1209495 NA 0.46 6.11 0.32 2.83e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg12463550 chr7:65579703 CRCP 0.43 6.09 0.32 3.08e-9 Aortic root size; LUSC cis rs11169552 0.510 rs4768853 chr12:50981785 A/C cg12884762 chr12:50931848 DIP2B -0.32 -5.79 -0.3 1.6e-8 Colorectal cancer; LUSC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg00310523 chr12:86230176 RASSF9 0.52 9.81 0.47 3.84e-20 Major depressive disorder; LUSC cis rs9650657 0.585 rs4841401 chr8:10489592 C/G cg27411982 chr8:10470053 RP1L1 -0.4 -6.12 -0.32 2.59e-9 Neuroticism; LUSC cis rs10779751 0.922 rs4845985 chr1:11288618 G/A cg08854313 chr1:11322531 MTOR 0.89 14.88 0.63 9.08e-39 Body mass index; LUSC cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.44 6.86 0.35 3.29e-11 Parkinson's disease; LUSC cis rs9612 1.000 rs7246677 chr19:44248625 G/A cg08581076 chr19:44259116 C19orf61 0.54 6.57 0.34 1.88e-10 Exhaled nitric oxide output; LUSC cis rs243505 0.559 rs10215794 chr7:148478895 C/G cg09806900 chr7:148480153 CUL1 0.68 10.03 0.48 7.22e-21 Inflammatory bowel disease;Crohn's disease; LUSC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg13902645 chr11:5959945 NA -0.53 -8.16 -0.41 7.13e-15 DNA methylation (variation); LUSC cis rs708547 0.836 rs1713997 chr4:57843863 G/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.69 9.64 0.47 1.42e-19 Response to bleomycin (chromatid breaks); LUSC cis rs6063312 0.518 rs6122718 chr20:47346225 A/G cg18078177 chr20:47281410 PREX1 -0.67 -9.95 -0.48 1.33e-20 Tonometry; LUSC cis rs10465746 0.935 rs6692233 chr1:84327214 A/G cg10977910 chr1:84465055 TTLL7 -0.41 -5.95 -0.31 6.75e-9 Obesity-related traits; LUSC cis rs1577917 0.740 rs9353327 chr6:86394066 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -9.87 -0.48 2.44e-20 Response to antipsychotic treatment; LUSC cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg03146154 chr1:46216737 IPP -0.5 -7.19 -0.37 4.3e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs713477 0.967 rs61976571 chr14:55908774 T/C cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs9747201 1.000 rs55638685 chr17:80107566 G/C cg17462356 chr17:80056334 FASN 0.46 6.21 0.32 1.56e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2274273 0.624 rs67795323 chr14:55797833 G/A cg04306507 chr14:55594613 LGALS3 0.48 9.69 0.47 1e-19 Protein biomarker; LUSC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg24846343 chr22:24311635 DDTL 0.64 13.9 0.61 5.59e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs116095464 0.558 rs34629844 chr5:200829 A/G cg22496380 chr5:211416 CCDC127 -0.86 -8.85 -0.44 5.26e-17 Breast cancer; LUSC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.5 0.46 4.18e-19 Bipolar disorder; LUSC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg05347473 chr6:146136440 FBXO30 -0.48 -7.99 -0.4 2.25e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg15664640 chr17:80829946 TBCD -0.73 -12.66 -0.57 2.8e-30 Breast cancer; LUSC cis rs1595825 0.735 rs2053394 chr2:198946335 C/T cg00982548 chr2:198649783 BOLL -0.54 -6.49 -0.33 3.19e-10 Ulcerative colitis; LUSC cis rs34779708 0.733 rs11597184 chr10:35397396 G/A cg03585969 chr10:35415529 CREM 0.62 9.1 0.45 8.61e-18 Inflammatory bowel disease;Crohn's disease; LUSC trans rs1493916 0.777 rs1493910 chr18:31318376 A/G cg27147174 chr7:100797783 AP1S1 -0.54 -8.49 -0.42 6.74e-16 Life satisfaction; LUSC cis rs1448094 0.967 rs2121892 chr12:86324556 G/T cg02569458 chr12:86230093 RASSF9 0.42 6.81 0.35 4.67e-11 Major depressive disorder; LUSC cis rs8032315 0.895 rs4932370 chr15:91404705 A/G cg05211768 chr15:91427848 FES -0.32 -6.02 -0.31 4.59e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg08677398 chr8:58056175 NA 0.49 7.78 0.39 8.84e-14 Developmental language disorder (linguistic errors); LUSC cis rs2859741 1.000 rs1773575 chr1:37505129 T/C cg09363841 chr1:37513479 NA -0.38 -7.21 -0.37 3.65e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg13939156 chr17:80058883 NA 0.33 6.62 0.34 1.41e-10 Life satisfaction; LUSC trans rs8072100 0.967 rs4580230 chr17:45738861 G/A cg03886242 chr7:26192032 NFE2L3 -0.38 -6.35 -0.33 7.18e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs66887589 0.777 rs2017058 chr4:120257739 T/C cg09307838 chr4:120376055 NA 0.5 7.71 0.39 1.5e-13 Diastolic blood pressure; LUSC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg19230755 chr7:65878503 NA -0.41 -5.74 -0.3 2.17e-8 Aortic root size; LUSC cis rs8141529 0.664 rs5762862 chr22:29252732 C/T cg02153584 chr22:29168773 CCDC117 0.51 7.02 0.36 1.22e-11 Lymphocyte counts; LUSC cis rs1107366 1.000 rs1107364 chr3:125904263 G/A cg08481491 chr3:125900108 ALDH1L1 -0.31 -6.27 -0.32 1.11e-9 Metabolite levels; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg13453750 chr1:205783389 SLC41A1 -0.33 -6.48 -0.33 3.23e-10 Menarche (age at onset); LUSC cis rs765787 0.530 rs2413776 chr15:45544170 A/G cg24006582 chr15:45444508 DUOX1 -0.6 -8.73 -0.43 1.24e-16 Uric acid levels; LUSC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.77 0.51 2.12e-23 Hip circumference adjusted for BMI; LUSC trans rs11935423 0.778 rs11933520 chr4:100492189 T/C cg02164153 chr5:172068145 NEURL1B -0.47 -6.1 -0.32 3e-9 Gut microbiome composition (summer); LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg03188948 chr7:1209495 NA 0.61 6.28 0.33 1.05e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs548181 0.668 rs540555 chr11:125486848 T/C cg03464685 chr11:125439445 EI24 1.17 14.17 0.61 4.96e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6674970 1.000 rs7546304 chr1:151114484 C/G cg03258749 chr1:151040405 MLLT11 -0.43 -6.45 -0.33 3.92e-10 Childhood ear infection; LUSC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg12310025 chr6:25882481 NA -0.5 -8.4 -0.42 1.27e-15 Intelligence (multi-trait analysis); LUSC cis rs12711979 0.765 rs7559345 chr2:3818523 G/A cg17052675 chr2:3827356 NA -0.57 -11.28 -0.53 3.32e-25 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs921968 0.541 rs599973 chr2:219387273 C/G cg02176678 chr2:219576539 TTLL4 0.73 14.3 0.62 1.64e-36 Mean corpuscular hemoglobin concentration; LUSC trans rs3733585 0.746 rs4318650 chr4:10016868 T/C cg26043149 chr18:55253948 FECH 0.48 7.22 0.37 3.5e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4919087 1.000 rs11189132 chr10:99086195 G/C cg25902810 chr10:99078978 FRAT1 -0.47 -6.8 -0.35 4.98e-11 Monocyte count; LUSC cis rs8005677 1.000 rs7145494 chr14:23399790 T/C cg00579484 chr14:23475993 C14orf93 0.39 5.74 0.3 2.12e-8 Cognitive ability (multi-trait analysis); LUSC cis rs12594515 0.935 rs8042519 chr15:45996341 G/C cg19682013 chr15:45996608 NA 0.39 5.9 0.31 8.69e-9 Waist circumference;Weight; LUSC cis rs13064411 0.696 rs6766615 chr3:113219342 T/C cg18753928 chr3:113234510 CCDC52 -0.51 -7.96 -0.4 2.8e-14 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs977987 0.806 rs4888418 chr16:75460306 C/G cg03315344 chr16:75512273 CHST6 0.49 9.26 0.45 2.61e-18 Dupuytren's disease; LUSC cis rs208520 1.000 rs72882086 chr6:66976671 G/A cg07460842 chr6:66804631 NA 0.93 12.22 0.56 1.2e-28 Exhaled nitric oxide output; LUSC cis rs4076764 0.881 rs10917758 chr1:163430652 G/A cg06092702 chr1:163392909 NA -0.43 -7.2 -0.37 4.04e-12 Motion sickness; LUSC cis rs9902453 0.967 rs4325622 chr17:28526475 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.51 0.42 5.87e-16 Coffee consumption (cups per day); LUSC cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg11984989 chr7:158649758 WDR60 -1.0 -17.57 -0.69 2.04e-49 Height; LUSC cis rs644799 0.710 rs666398 chr11:95551136 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.51 0.59 1.8e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs2262909 0.962 rs4932952 chr19:22246788 G/A cg17074339 chr11:11642133 GALNTL4 0.47 7.17 0.37 4.94e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg15369054 chr17:80825471 TBCD 0.7 11.78 0.54 4.96e-27 Breast cancer; LUSC cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg09479241 chr17:27052676 TLCD1 0.43 5.78 0.3 1.74e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.62 -9.47 -0.46 5.16e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs727505 0.607 rs10464674 chr7:124791551 A/G cg23710748 chr7:124431027 NA -0.4 -6.98 -0.36 1.61e-11 Lewy body disease; LUSC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.38 0.33 5.95e-10 Menopause (age at onset); LUSC cis rs2625529 0.652 rs8040216 chr15:72255249 C/T cg16672083 chr15:72433130 SENP8 0.49 8.08 0.4 1.2e-14 Red blood cell count; LUSC cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg00677455 chr12:58241039 CTDSP2 0.64 9.0 0.44 1.69e-17 Multiple sclerosis; LUSC trans rs931812 0.895 rs7831714 chr8:101913987 C/T cg20993868 chr7:22813445 NA 0.62 11.14 0.52 9.89e-25 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs9372498 0.536 rs62422235 chr6:118971913 G/A cg18833306 chr6:118973337 C6orf204 -0.46 -5.85 -0.3 1.2e-8 Diastolic blood pressure; LUSC trans rs10506458 0.915 rs12426308 chr12:63405778 C/T cg22491629 chr6:157744540 C6orf35 -0.92 -11.3 -0.53 2.83e-25 Hemostatic factors and hematological phenotypes; LUSC cis rs2404602 0.647 rs11072616 chr15:76985269 T/C cg23625390 chr15:77176239 SCAPER -0.66 -10.1 -0.48 4.21e-21 Blood metabolite levels; LUSC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg00509249 chr6:109615579 CCDC162 -0.33 -6.05 -0.31 3.86e-9 Reticulocyte fraction of red cells; LUSC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg01475377 chr6:109611718 NA -0.38 -6.75 -0.35 6.74e-11 Reticulocyte fraction of red cells; LUSC cis rs7191439 0.858 rs8050715 chr16:88780923 C/G cg02389323 chr16:88786976 FAM38A 1.02 10.55 0.5 1.23e-22 Plateletcrit; LUSC trans rs62238980 0.614 rs77112134 chr22:32394449 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs6601327 0.602 rs7829463 chr8:9649691 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.38 -0.33 5.92e-10 Multiple myeloma (hyperdiploidy); LUSC cis rs760805 0.965 rs11249203 chr1:25258585 G/C cg22509179 chr1:25234806 RUNX3 -0.6 -10.09 -0.48 4.48e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1322512 1.000 rs1407488 chr6:152945777 G/T cg27316956 chr6:152958899 SYNE1 -0.33 -5.65 -0.3 3.45e-8 Tonometry; LUSC cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg23788917 chr6:8435910 SLC35B3 0.51 7.48 0.38 6.55e-13 Motion sickness; LUSC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg07343612 chr16:622815 PIGQ -0.75 -13.19 -0.59 2.94e-32 Height; LUSC cis rs6964587 0.869 rs6946764 chr7:91539003 A/G cg17063962 chr7:91808500 NA -0.53 -8.18 -0.41 6.04e-15 Breast cancer; LUSC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg26338869 chr17:61819248 STRADA 0.41 5.94 0.31 7.17e-9 Prudent dietary pattern; LUSC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg12463550 chr7:65579703 CRCP 0.55 8.24 0.41 3.89e-15 Aortic root size; LUSC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg17211192 chr8:82754475 SNX16 -0.81 -11.1 -0.52 1.45e-24 Diastolic blood pressure; LUSC cis rs4588572 0.643 rs7700390 chr5:77789532 T/C cg11547950 chr5:77652471 NA -0.61 -8.57 -0.42 3.88e-16 Triglycerides; LUSC cis rs983392 0.679 rs7128450 chr11:60031270 G/C cg24026212 chr11:59952134 MS4A6A 0.36 6.32 0.33 8.42e-10 Alzheimer's disease (late onset); LUSC cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.45 0.38 8.31e-13 Colorectal cancer; LUSC cis rs4144027 0.967 rs56126771 chr14:104361143 C/G cg12183467 chr14:104352244 NA 0.29 5.69 0.3 2.73e-8 Blood metabolite levels; LUSC cis rs6964587 1.000 rs733957 chr7:91707197 C/T cg17063962 chr7:91808500 NA 0.6 9.35 0.46 1.3e-18 Breast cancer; LUSC cis rs1008375 0.900 rs12650220 chr4:17595365 A/T cg16339924 chr4:17578868 LAP3 0.63 9.74 0.47 6.69e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7582180 0.629 rs6731549 chr2:100939937 T/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.6 -0.43 3.22e-16 Intelligence (multi-trait analysis); LUSC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.84 13.05 0.58 9.63e-32 Cognitive test performance; LUSC cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.74 -13.08 -0.58 7.37e-32 Personality dimensions; LUSC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg06238570 chr21:40685208 BRWD1 0.47 7.29 0.37 2.23e-12 Cognitive function; LUSC cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg11102782 chr19:18549136 ISYNA1 0.32 6.09 0.32 3.07e-9 Breast cancer; LUSC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg18402987 chr7:1209562 NA 0.73 7.84 0.39 5.91e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs59104589 0.550 rs12612038 chr2:242369685 A/G cg14842376 chr2:242211374 HDLBP 0.52 6.05 0.31 3.97e-9 Fibrinogen levels; LUSC cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg00484396 chr16:3507460 NAT15 0.49 7.34 0.37 1.6e-12 Body mass index (adult); LUSC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs12912251 0.947 rs12898460 chr15:38986813 C/T cg01338139 chr15:38987640 C15orf53 -0.48 -6.45 -0.33 3.95e-10 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); LUSC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg11941060 chr3:133502564 NA 0.59 9.2 0.45 3.9e-18 Iron status biomarkers; LUSC cis rs7759001 0.857 rs6923539 chr6:27362483 C/A cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC trans rs2797160 0.967 rs1777224 chr6:126019527 T/C cg05039488 chr6:79577232 IRAK1BP1 0.46 7.05 0.36 1.01e-11 Endometrial cancer; LUSC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.59 0.5 8.68e-23 Colonoscopy-negative controls vs population controls; LUSC trans rs6977660 0.652 rs10275246 chr7:19851059 G/A cg11717054 chr11:279423 NLRP6 -0.54 -6.18 -0.32 1.92e-9 Thyroid stimulating hormone; LUSC cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg24130564 chr14:104152367 KLC1 -0.48 -7.05 -0.36 1.01e-11 Intelligence (multi-trait analysis); LUSC cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg16240275 chr20:61666158 NCRNA00029 0.42 9.39 0.46 9.76e-19 Prostate cancer (SNP x SNP interaction); LUSC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg14558114 chr2:88469736 THNSL2 0.8 7.13 0.36 6.19e-12 Plasma clusterin levels; LUSC cis rs970548 0.688 rs2082110 chr10:45931070 A/G cg23750895 chr10:46321377 AGAP4 -0.55 -5.68 -0.3 2.93e-8 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs9733 0.540 rs4971041 chr1:150537357 C/T cg13175981 chr1:150552382 MCL1 0.46 6.29 0.33 9.94e-10 Tonsillectomy; LUSC trans rs11098499 0.954 rs3733524 chr4:120423729 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.24 0.32 1.36e-9 Corneal astigmatism; LUSC cis rs11122272 0.735 rs2749707 chr1:231527316 C/T cg06096015 chr1:231504339 EGLN1 0.57 10.02 0.48 7.5e-21 Hemoglobin concentration; LUSC cis rs2629540 0.793 rs10794180 chr10:126449306 T/A cg08799069 chr10:126477246 METTL10 -0.7 -10.56 -0.5 1.12e-22 Cocaine dependence; LUSC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg22823121 chr1:150693482 HORMAD1 0.49 7.13 0.36 6.37e-12 Melanoma; LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.06 0.61 1.38e-35 Platelet count; LUSC cis rs2387326 0.717 rs10829343 chr10:129944496 T/C cg16087940 chr10:129947807 NA -0.39 -6.0 -0.31 5e-9 Select biomarker traits; LUSC trans rs57046232 0.552 rs4402836 chr20:6338026 G/A cg17788362 chr6:86352627 SYNCRIP 0.42 5.97 0.31 5.94e-9 Colorectal cancer; LUSC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg13798912 chr7:905769 UNC84A -0.58 -5.83 -0.3 1.29e-8 Cerebrospinal P-tau181p levels; LUSC cis rs7615316 0.789 rs2862743 chr3:142112572 C/T cg16271453 chr3:142027066 XRN1 -0.37 -6.54 -0.34 2.3e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg00277334 chr10:82204260 NA -0.94 -19.27 -0.73 3.78e-56 Post bronchodilator FEV1; LUSC cis rs9929218 0.954 rs7198799 chr16:68818390 C/T cg02972257 chr16:68554789 NA 0.42 5.77 0.3 1.86e-8 Colorectal cancer; LUSC trans rs2243480 1.000 rs316318 chr7:65612904 A/G cg10756647 chr7:56101905 PSPH 0.88 8.91 0.44 3.39e-17 Diabetic kidney disease; LUSC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg13939156 chr17:80058883 NA 0.34 6.85 0.35 3.54e-11 Life satisfaction; LUSC cis rs968451 0.526 rs5757617 chr22:39722714 G/C cg17798944 chr22:39715225 SNORD43;RPL3 0.77 12.43 0.56 2.02e-29 Primary biliary cholangitis; LUSC trans rs9291683 0.588 rs3733586 chr4:9997534 C/T cg26043149 chr18:55253948 FECH 0.46 6.8 0.35 4.9e-11 Bone mineral density; LUSC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg15468180 chr1:107600409 PRMT6 -0.39 -6.25 -0.32 1.24e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs6736093 0.966 rs870763 chr2:112745481 C/T cg12686935 chr2:112915763 FBLN7 0.37 5.96 0.31 6.57e-9 Coronary artery disease; LUSC cis rs7264396 0.836 rs961020 chr20:34182069 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -7.51 -0.38 5.55e-13 Total cholesterol levels; LUSC cis rs7809950 0.678 rs2237661 chr7:106863123 T/C cg23024343 chr7:107201750 COG5 -0.66 -9.34 -0.46 1.35e-18 Coronary artery disease; LUSC cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg13010199 chr12:38710504 ALG10B 0.67 10.16 0.49 2.56e-21 Bladder cancer; LUSC trans rs3808502 0.527 rs2736374 chr8:11113828 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.4 -0.38 1.14e-12 Neuroticism; LUSC cis rs9297145 0.585 rs13235218 chr7:98785080 C/T cg05967295 chr7:98741636 SMURF1 -0.61 -9.27 -0.45 2.45e-18 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg26314531 chr2:26401878 FAM59B -0.69 -9.28 -0.45 2.17e-18 Gut microbiome composition (summer); LUSC cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg18252515 chr7:66147081 NA -1.21 -13.88 -0.6 6.79e-35 Diabetic kidney disease; LUSC cis rs12049330 0.825 rs7536292 chr1:109894693 A/G cg05049280 chr1:110155535 GNAT2 0.4 5.91 0.31 8.38e-9 Major depressive disorder; LUSC cis rs6977660 0.943 rs10249996 chr7:19844935 G/A cg05791153 chr7:19748676 TWISTNB 0.55 6.21 0.32 1.6e-9 Thyroid stimulating hormone; LUSC cis rs8060686 0.545 rs7199878 chr16:68186301 A/G cg09835421 chr16:68378352 PRMT7 -0.58 -6.1 -0.32 2.87e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs765787 0.530 rs4775837 chr15:45537684 G/T cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg20848291 chr7:100343083 ZAN 0.39 6.14 0.32 2.33e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg01579765 chr21:45077557 HSF2BP 0.53 11.09 0.52 1.49e-24 Mean corpuscular volume; LUSC cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg13010199 chr12:38710504 ALG10B 0.65 9.84 0.47 3.13e-20 Bladder cancer; LUSC cis rs56235845 0.665 rs4976685 chr5:176766177 C/T cg17509989 chr5:176798049 RGS14 -0.67 -10.62 -0.5 7.02e-23 Hemoglobin concentration;Hematocrit; LUSC cis rs9443645 0.527 rs9352691 chr6:79785607 C/T cg05283184 chr6:79620031 NA -0.47 -8.98 -0.44 2.04e-17 Intelligence (multi-trait analysis); LUSC cis rs6120849 0.754 rs6088678 chr20:33607551 A/G cg24642439 chr20:33292090 TP53INP2 -0.6 -6.59 -0.34 1.71e-10 Protein C levels; LUSC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg19748678 chr4:122722346 EXOSC9 0.48 7.29 0.37 2.21e-12 Type 2 diabetes; LUSC cis rs4964805 0.594 rs751448 chr12:104167185 C/T cg02344784 chr12:104178138 NT5DC3 0.37 5.94 0.31 7.07e-9 Attention deficit hyperactivity disorder; LUSC cis rs136211 0.599 rs9610497 chr22:36767359 C/T cg16924664 chr22:36878180 TXN2 0.41 6.15 0.32 2.22e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7215564 0.818 rs78905718 chr17:78604278 G/A cg09596252 chr17:78655493 RPTOR 0.55 6.28 0.32 1.06e-9 Myopia (pathological); LUSC trans rs17683430 0.702 rs61742196 chr22:32369435 C/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs354225 0.615 rs12713274 chr2:54848728 C/T cg01766943 chr2:54829624 SPTBN1 -0.43 -7.23 -0.37 3.4e-12 Schizophrenia; LUSC trans rs61931739 0.620 rs815052 chr12:33727270 C/A cg26384229 chr12:38710491 ALG10B 0.42 6.17 0.32 1.97e-9 Morning vs. evening chronotype; LUSC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg08736216 chr1:53307985 ZYG11A -0.29 -5.93 -0.31 7.48e-9 Monocyte count; LUSC cis rs3126085 0.935 rs6587647 chr1:152192631 C/T cg03465714 chr1:152285911 FLG -0.42 -5.79 -0.3 1.64e-8 Atopic dermatitis; LUSC trans rs7980799 0.682 rs4931719 chr12:33602986 G/A cg13010199 chr12:38710504 ALG10B -0.44 -6.46 -0.33 3.74e-10 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg13395646 chr4:1353034 KIAA1530 -0.56 -8.73 -0.43 1.28e-16 Obesity-related traits; LUSC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg06640241 chr16:89574553 SPG7 -0.86 -15.87 -0.66 1.11e-42 Multiple myeloma (IgH translocation); LUSC cis rs6456156 0.524 rs6934043 chr6:167466449 C/T cg06454157 chr6:167490870 NA -0.28 -6.85 -0.35 3.67e-11 Primary biliary cholangitis; LUSC cis rs7647973 0.710 rs11130208 chr3:49615624 G/T cg07636037 chr3:49044803 WDR6 0.55 5.69 0.3 2.82e-8 Menarche (age at onset); LUSC cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg03517284 chr6:25882590 NA 0.66 11.45 0.53 7.59e-26 Blood metabolite levels; LUSC cis rs2108225 0.872 rs2051954 chr7:107441097 G/C cg18560240 chr7:107437656 SLC26A3 -0.44 -6.57 -0.34 1.9e-10 Ulcerative colitis; LUSC cis rs782590 0.620 rs4322879 chr2:55797033 G/T cg18811423 chr2:55921094 PNPT1 -0.66 -9.39 -0.46 9.8e-19 Metabolic syndrome; LUSC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg02782426 chr3:40428986 ENTPD3 0.33 6.08 0.32 3.26e-9 Renal cell carcinoma; LUSC cis rs7605827 0.930 rs2380649 chr2:15532612 A/C cg19274914 chr2:15703543 NA 0.45 8.86 0.44 4.75e-17 Educational attainment (years of education); LUSC cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg08645402 chr16:4508243 NA 0.49 7.93 0.4 3.41e-14 Schizophrenia; LUSC cis rs9788682 0.694 rs10851906 chr15:78774676 A/G cg24631222 chr15:78858424 CHRNA5 0.65 8.65 0.43 2.2e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC trans rs12987465 0.545 rs116021360 chr2:49708739 G/T cg08691775 chr8:134310658 NDRG1 -0.35 -6.0 -0.31 5.13e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide); LUSC trans rs11098499 0.863 rs1383532 chr4:120434404 A/T cg19731845 chr4:166199412 KLHL2;GK3P -0.48 -6.62 -0.34 1.45e-10 Corneal astigmatism; LUSC cis rs734999 0.545 rs6666788 chr1:2567500 A/G cg18854424 chr1:2615690 NA -0.52 -10.59 -0.5 8.5e-23 Ulcerative colitis; LUSC cis rs12348691 0.503 rs1348386 chr9:100612807 A/G cg13688889 chr9:100608707 NA -0.75 -11.91 -0.55 1.72e-27 Alopecia areata; LUSC trans rs1218582 0.772 rs11264290 chr1:154912300 C/T cg05839875 chr5:39203190 FYB -0.32 -6.03 -0.31 4.39e-9 Prostate cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12385672 chr10:18940645 NSUN6 -0.41 -6.03 -0.31 4.25e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg05729581 chr11:3078854 CARS 0.53 8.34 0.41 2.04e-15 Longevity; LUSC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs72634258 0.519 rs744001 chr1:7934557 G/A cg26816564 chr1:7831052 VAMP3 0.73 9.49 0.46 4.48e-19 Inflammatory bowel disease; LUSC cis rs6500395 0.775 rs28481630 chr16:48663664 G/C cg04672837 chr16:48644449 N4BP1 0.47 6.97 0.36 1.73e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg23575115 chr20:49348591 PARD6B -0.45 -5.97 -0.31 6.05e-9 Hepatitis; LUSC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg21963583 chr11:68658836 MRPL21 0.54 8.24 0.41 4.03e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg14433983 chr11:636460 DRD4 -0.35 -5.88 -0.31 9.78e-9 Systemic lupus erythematosus; LUSC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs9814567 1.000 rs7426847 chr3:134267519 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 13.56 0.6 1.12e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs921968 0.521 rs56923478 chr2:219638539 A/G cg02176678 chr2:219576539 TTLL4 -0.55 -9.78 -0.47 4.92e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg26338869 chr17:61819248 STRADA 0.42 6.1 0.32 2.96e-9 Prudent dietary pattern; LUSC cis rs9905704 0.918 rs4132924 chr17:56937653 C/T cg12560992 chr17:57184187 TRIM37 0.57 8.05 0.4 1.47e-14 Testicular germ cell tumor; LUSC cis rs1881396 0.891 rs62131879 chr2:27755112 T/G cg27432699 chr2:27873401 GPN1 0.68 9.27 0.45 2.3e-18 Nonalcoholic fatty liver disease; LUSC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg20135002 chr11:47629003 NA 0.49 7.8 0.39 8.06e-14 Subjective well-being; LUSC cis rs9527 0.590 rs10509766 chr10:104926334 T/C cg05855489 chr10:104503620 C10orf26 0.52 7.88 0.4 4.72e-14 Arsenic metabolism; LUSC cis rs2742234 0.541 rs7096500 chr10:43712095 C/T cg15436174 chr10:43711423 RASGEF1A 0.44 7.06 0.36 9.75e-12 Hirschsprung disease; LUSC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg07936489 chr17:37558343 FBXL20 0.72 9.96 0.48 1.28e-20 Glomerular filtration rate (creatinine); LUSC cis rs926938 0.527 rs7526844 chr1:115543759 T/C cg01522456 chr1:115632236 TSPAN2 -0.41 -6.35 -0.33 6.93e-10 Autism; LUSC cis rs897984 0.537 rs8045637 chr16:30818662 C/T cg02466173 chr16:30829666 NA -0.68 -16.25 -0.66 3.57e-44 Dementia with Lewy bodies; LUSC cis rs10751667 1.000 rs7927156 chr11:970607 A/G ch.11.42038R chr11:967971 AP2A2 0.5 7.29 0.37 2.22e-12 Alzheimer's disease (late onset); LUSC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg02782426 chr3:40428986 ENTPD3 -0.31 -6.14 -0.32 2.28e-9 Renal cell carcinoma; LUSC cis rs9902453 0.874 rs4474741 chr17:28148117 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -9.36 -0.46 1.21e-18 Coffee consumption (cups per day); LUSC cis rs2624839 0.704 rs2624838 chr3:50205642 C/G cg14019146 chr3:50243930 SLC38A3 -0.48 -11.09 -0.52 1.5e-24 Intelligence (multi-trait analysis); LUSC cis rs2898290 0.622 rs1478890 chr8:11355602 C/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.69 -0.34 9.66e-11 Systolic blood pressure; LUSC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg23711669 chr6:146136114 FBXO30 0.9 16.54 0.67 2.68e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs5769765 0.542 rs5770725 chr22:50256309 C/T cg02269571 chr22:50332266 NA 0.59 7.57 0.38 3.67e-13 Schizophrenia; LUSC cis rs977987 0.815 rs1364078 chr16:75396881 T/C cg04384234 chr16:75411784 CFDP1 -0.45 -7.5 -0.38 5.83e-13 Dupuytren's disease; LUSC cis rs10186029 0.676 rs35922168 chr2:213949018 T/C cg08319019 chr2:214017104 IKZF2 0.61 9.03 0.44 1.37e-17 Systemic sclerosis; LUSC cis rs1559088 0.739 rs9304845 chr19:33592794 A/G cg17764715 chr19:33622953 WDR88 0.59 8.01 0.4 1.99e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9329221 0.527 rs6989657 chr8:10330873 C/G cg21775007 chr8:11205619 TDH 0.42 5.89 0.31 9.33e-9 Neuroticism; LUSC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg04362960 chr10:104952993 NT5C2 -0.6 -9.79 -0.47 4.69e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs155076 0.938 rs261375 chr13:21871882 A/G cg11317459 chr13:21872234 NA 1.14 15.42 0.64 7.01e-41 White matter hyperintensity burden; LUSC cis rs3820068 0.581 rs6429762 chr1:15945595 A/C cg13390004 chr1:15929781 NA 0.41 6.9 0.35 2.6e-11 Systolic blood pressure; LUSC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg26924012 chr15:45694286 SPATA5L1 1.14 20.94 0.75 9e-63 Homoarginine levels; LUSC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg12863693 chr15:85201151 NMB 0.34 6.78 0.35 5.49e-11 Schizophrenia; LUSC cis rs1256061 0.654 rs1256033 chr14:64745399 A/G cg21174375 chr14:64681225 SYNE2 0.34 6.19 0.32 1.75e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC trans rs2262909 0.962 rs401424 chr19:22232023 A/G cg05197062 chr11:11642011 GALNTL4 -0.49 -6.9 -0.35 2.67e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg26408565 chr15:76604113 ETFA -0.49 -7.88 -0.4 4.81e-14 Blood metabolite levels; LUSC cis rs11190604 1.000 rs2295774 chr10:102265847 A/C cg23241863 chr10:102295624 HIF1AN 0.49 5.7 0.3 2.69e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6066835 1.000 rs6095244 chr20:47318774 T/C cg18078177 chr20:47281410 PREX1 0.71 5.96 0.31 6.29e-9 Multiple myeloma; LUSC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg11344533 chr11:111475393 SIK2 0.48 6.45 0.33 3.92e-10 Primary sclerosing cholangitis; LUSC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg18230493 chr5:56204884 C5orf35 -1.0 -15.35 -0.64 1.32e-40 Initial pursuit acceleration; LUSC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg07424592 chr7:64974309 NA 0.64 5.73 0.3 2.2e-8 Diabetic kidney disease; LUSC cis rs7072216 0.763 rs10732782 chr10:100166506 C/A cg26618903 chr10:100175079 PYROXD2 -0.48 -8.99 -0.44 1.93e-17 Metabolite levels; LUSC cis rs765787 0.530 rs11634794 chr15:45534492 A/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.69 -0.43 1.64e-16 Uric acid levels; LUSC cis rs2637266 0.935 rs2583050 chr10:78403615 C/T cg18941641 chr10:78392320 NA 0.42 7.62 0.38 2.67e-13 Pulmonary function; LUSC cis rs17270561 0.609 rs9358885 chr6:25758024 T/C cg16482183 chr6:26056742 HIST1H1C 0.66 9.2 0.45 3.85e-18 Iron status biomarkers; LUSC cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg01849466 chr14:104193079 ZFYVE21 -0.61 -9.72 -0.47 7.65e-20 Schizophrenia; LUSC cis rs68170813 0.559 rs3801963 chr7:106898036 C/T cg02696742 chr7:106810147 HBP1 -0.63 -9.64 -0.47 1.44e-19 Coronary artery disease; LUSC cis rs2835872 0.733 rs2850124 chr21:39036763 T/A cg20424643 chr21:39039972 KCNJ6 -0.43 -7.24 -0.37 3.08e-12 Electroencephalographic traits in alcoholism; LUSC trans rs10510217 0.872 rs73820109 chr3:1820057 T/C cg22108469 chr5:174158984 NA -0.42 -6.03 -0.31 4.42e-9 Total ventricular volume; LUSC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.44 0.76 1e-64 Prudent dietary pattern; LUSC trans rs66887589 0.616 rs6843509 chr4:120220196 G/A cg25214090 chr10:38739885 LOC399744 0.39 6.05 0.31 3.83e-9 Diastolic blood pressure; LUSC cis rs804280 0.542 rs36100659 chr8:11791653 A/T cg21775007 chr8:11205619 TDH 0.46 6.55 0.34 2.18e-10 Myopia (pathological); LUSC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg09417038 chr21:47716443 C21orf57 0.39 6.34 0.33 7.52e-10 Testicular germ cell tumor; LUSC cis rs4889855 0.530 rs4889863 chr17:78550468 C/T cg16591659 chr17:78472290 NA -0.33 -6.11 -0.32 2.75e-9 Fractional excretion of uric acid; LUSC cis rs8077889 0.956 rs4792910 chr17:41840229 T/C cg26893861 chr17:41843967 DUSP3 0.99 14.88 0.63 9.02e-39 Triglycerides; LUSC cis rs9467773 1.000 rs6925895 chr6:26572165 G/T cg05738196 chr6:26577821 NA 0.82 15.84 0.66 1.47e-42 Intelligence (multi-trait analysis); LUSC cis rs9341808 0.530 rs3805876 chr6:81031539 C/A cg08355045 chr6:80787529 NA 0.51 8.89 0.44 3.84e-17 Sitting height ratio; LUSC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg06112835 chr11:68658793 MRPL21 0.51 7.81 0.39 7.61e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs72781680 1.000 rs72781667 chr2:24225667 A/G cg20701182 chr2:24300061 SF3B14 0.6 6.32 0.33 8.22e-10 Lymphocyte counts; LUSC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg22875332 chr1:76189707 ACADM 0.83 13.89 0.61 6.12e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg14789911 chr21:47582049 C21orf56 -0.4 -6.3 -0.33 9.43e-10 Testicular germ cell tumor; LUSC cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg08085267 chr17:45401833 C17orf57 -0.47 -6.62 -0.34 1.47e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs950027 0.549 rs1719250 chr15:45609773 A/G cg14582100 chr15:45693742 SPATA5L1 0.43 7.95 0.4 2.86e-14 Response to fenofibrate (adiponectin levels); LUSC cis rs757081 0.667 rs34724588 chr11:17137581 T/C cg15432903 chr11:17409602 KCNJ11 -0.39 -6.1 -0.32 2.97e-9 Systolic blood pressure; LUSC cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.84 -0.35 3.68e-11 Monocyte percentage of white cells; LUSC cis rs7944584 0.655 rs2856653 chr11:47361084 T/C cg20307385 chr11:47447363 PSMC3 -0.71 -10.97 -0.51 4.04e-24 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs62238980 0.614 rs2413063 chr22:32458252 A/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs12220238 0.730 rs10740421 chr10:75941002 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.58 6.79 0.35 5.25e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs654950 0.783 rs668359 chr1:42003425 A/C cg06885757 chr1:42089581 HIVEP3 -0.41 -8.0 -0.4 2e-14 Airway imaging phenotypes; LUSC cis rs6426558 0.537 rs1320494 chr1:227241300 A/T cg10327440 chr1:227177885 CDC42BPA 0.55 7.43 0.38 9.42e-13 Neutrophil percentage of white cells; LUSC cis rs6429082 0.764 rs291369 chr1:235691913 T/C cg26050004 chr1:235667680 B3GALNT2 0.6 7.98 0.4 2.36e-14 Adiposity; LUSC cis rs899997 0.862 rs8043123 chr15:78973393 C/T cg04896959 chr15:78267971 NA -0.44 -8.72 -0.43 1.3e-16 Coronary artery disease or large artery stroke; LUSC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg25019033 chr10:957182 NA -0.52 -6.58 -0.34 1.82e-10 Eosinophil percentage of granulocytes; LUSC cis rs7178572 0.568 rs8037561 chr15:77680462 A/G cg22256960 chr15:77711686 NA -0.5 -7.92 -0.4 3.57e-14 Type 2 diabetes; LUSC trans rs2204008 0.665 rs11179830 chr12:38220966 T/C cg06521331 chr12:34319734 NA -0.4 -6.21 -0.32 1.59e-9 Bladder cancer; LUSC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs8072100 0.967 rs4239162 chr17:45755810 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.35 -5.83 -0.3 1.28e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg24060327 chr5:131705240 SLC22A5 -0.51 -8.5 -0.42 6.24e-16 Breast cancer; LUSC cis rs2952156 0.959 rs1495101 chr17:37832103 C/A cg00129232 chr17:37814104 STARD3 -0.43 -6.25 -0.32 1.26e-9 Asthma; LUSC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.54 7.33 0.37 1.78e-12 Multiple sclerosis; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg16538604 chr4:2010703 WHSC2 -0.52 -6.41 -0.33 4.88e-10 Bipolar disorder and schizophrenia; LUSC cis rs68170813 0.652 rs76742243 chr7:107144202 G/A cg02696742 chr7:106810147 HBP1 -0.64 -8.62 -0.43 2.79e-16 Coronary artery disease; LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs7916697 0.947 rs56238729 chr10:70001640 T/C cg06988349 chr10:69991859 ATOH7 0.33 5.81 0.3 1.47e-8 Optic disc area; LUSC cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg08999081 chr20:33150536 PIGU -0.53 -10.56 -0.5 1.14e-22 Glomerular filtration rate (creatinine); LUSC trans rs1864729 1.000 rs2567769 chr8:98297848 G/A cg08679828 chr8:102218111 ZNF706 -0.8 -6.47 -0.33 3.47e-10 Estradiol plasma levels (breast cancer); LUSC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg17294928 chr15:75287854 SCAMP5 0.41 5.93 0.31 7.62e-9 Breast cancer; LUSC cis rs10276381 1.000 rs7796417 chr7:28186119 G/C cg23620719 chr7:28220237 JAZF1 0.59 6.55 0.34 2.15e-10 Crohn's disease; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg04319882 chr16:19535207 CP110 0.44 5.99 0.31 5.57e-9 Neuroticism; LUSC trans rs35110281 0.574 rs1836856 chr21:44964638 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.9 0.48 1.97e-20 Mean corpuscular volume; LUSC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg09034736 chr1:150693464 HORMAD1 0.45 6.42 0.33 4.74e-10 Melanoma; LUSC cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.63 10.18 0.49 2.26e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs611744 0.625 rs11779824 chr8:109278689 G/A cg21045802 chr8:109455806 TTC35 0.42 6.58 0.34 1.79e-10 Dupuytren's disease; LUSC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.79 -0.35 5.12e-11 Crohn's disease; LUSC cis rs1348850 0.918 rs4893966 chr2:178470138 A/G cg22681709 chr2:178499509 PDE11A -0.47 -8.69 -0.43 1.71e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg19539318 chr2:172544773 DYNC1I2 -0.44 -6.4 -0.33 5.17e-10 Electrocardiographic conduction measures; LUSC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10779751 0.879 rs7543400 chr1:11283964 C/G cg08854313 chr1:11322531 MTOR 0.93 15.93 0.66 6.78e-43 Body mass index; LUSC trans rs931812 0.895 rs4734016 chr8:101910071 C/T cg20993868 chr7:22813445 NA 0.66 11.99 0.55 8.97e-28 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs983392 0.805 rs11230184 chr11:59965789 G/A cg24026212 chr11:59952134 MS4A6A -0.36 -6.16 -0.32 2.09e-9 Alzheimer's disease (late onset); LUSC cis rs11190604 1.000 rs6584379 chr10:102224490 G/A cg16342193 chr10:102329863 NA -0.35 -6.39 -0.33 5.63e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7605827 0.930 rs7568678 chr2:15596203 C/T cg19274914 chr2:15703543 NA 0.49 8.7 0.43 1.56e-16 Educational attainment (years of education); LUSC cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg04896959 chr15:78267971 NA -0.52 -11.52 -0.53 4.38e-26 Diastolic blood pressure; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg22535103 chr8:58192502 C8orf71 -0.76 -7.99 -0.4 2.26e-14 Developmental language disorder (linguistic errors); LUSC cis rs11209002 0.915 rs6588240 chr1:67577367 A/T cg02640540 chr1:67518911 SLC35D1 0.69 7.59 0.38 3.25e-13 Crohn's disease; LUSC cis rs6815814 0.861 rs10012017 chr4:38784633 G/T cg06935464 chr4:38784597 TLR10 0.46 5.87 0.31 1.07e-8 Breast cancer; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg17648537 chr2:86333281 PTCD3;POLR1A 0.42 6.38 0.33 5.88e-10 Asthma; LUSC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg17376030 chr22:41985996 PMM1 -0.48 -6.04 -0.31 4.06e-9 Vitiligo; LUSC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg15212455 chr7:39170539 POU6F2 0.6 9.99 0.48 9.71e-21 IgG glycosylation; LUSC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg18402987 chr7:1209562 NA 0.42 5.65 0.3 3.4e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11098499 0.687 rs71610270 chr4:120287436 A/G cg09307838 chr4:120376055 NA 0.69 10.1 0.48 4.13e-21 Corneal astigmatism; LUSC trans rs984440 0.922 rs7008947 chr8:139075668 G/A cg03334052 chr1:168888044 NA -0.44 -6.05 -0.31 3.85e-9 Obesity-related traits; LUSC cis rs418053 0.657 rs204222 chr6:13697476 C/T cg02206980 chr6:13574034 SIRT5 -0.3 -6.16 -0.32 2.14e-9 Breast cancer; LUSC cis rs2732480 0.538 rs2468943 chr12:48747249 G/T cg04545296 chr12:48745243 ZNF641 -0.33 -6.21 -0.32 1.61e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs3733585 0.563 rs881971 chr4:9930962 A/G cg11266682 chr4:10021025 SLC2A9 -0.44 -8.01 -0.4 1.95e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7568458 0.875 rs2044474 chr2:85758790 G/A cg23752985 chr2:85803571 VAMP8 0.33 7.06 0.36 9.68e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg06634786 chr22:41940651 POLR3H 0.53 6.3 0.33 9.27e-10 Vitiligo; LUSC cis rs7590720 1.000 rs7590720 chr2:216898658 A/G cg12620499 chr2:216877984 MREG -0.92 -14.51 -0.62 2.51e-37 Alcohol dependence; LUSC cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg06784218 chr1:46089804 CCDC17 -0.51 -9.49 -0.46 4.39e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg12748703 chr10:97453984 TCTN3 0.42 6.26 0.32 1.19e-9 Metabolite levels (Pyroglutamine); LUSC cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg06636001 chr8:8085503 FLJ10661 0.53 8.0 0.4 2.06e-14 Joint mobility (Beighton score); LUSC cis rs13315871 1.000 rs13096020 chr3:58367771 G/A cg20936604 chr3:58311152 NA -0.63 -5.85 -0.31 1.15e-8 Cholesterol, total; LUSC cis rs789859 1.000 rs789859 chr3:194405888 G/T cg02072170 chr3:194406190 FAM43A 0.36 7.62 0.38 2.62e-13 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs9303542 0.592 rs34378400 chr17:46589265 A/G cg09704116 chr17:46666958 LOC404266 -0.37 -6.67 -0.34 1.07e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg00409905 chr10:38381863 ZNF37A 0.35 5.94 0.31 7.29e-9 Extrinsic epigenetic age acceleration; LUSC trans rs4940203 0.625 rs67502388 chr18:50226678 G/C cg14465628 chr9:98125437 NA 0.3 6.08 0.32 3.25e-9 Obesity-related traits; LUSC cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg16584290 chr5:462447 EXOC3 0.47 8.38 0.42 1.53e-15 Cystic fibrosis severity; LUSC trans rs372883 0.613 rs1153290 chr21:30687404 G/T cg14791747 chr16:20752902 THUMPD1 0.43 6.13 0.32 2.45e-9 Pancreatic cancer; LUSC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12140468 chr1:234509341 C1orf31 -0.4 -6.15 -0.32 2.16e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs936229 0.784 rs12906946 chr15:75153140 A/G cg14664628 chr15:75095509 CSK -0.81 -11.95 -0.55 1.18e-27 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs4820539 1.000 rs4822357 chr22:23473231 A/G cg14186256 chr22:23484241 RTDR1 0.86 15.46 0.65 4.6e-41 Bone mineral density; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19701416 chr10:28592092 NA 0.44 6.79 0.35 5.24e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg13535736 chr9:111863775 C9orf5 -0.42 -6.98 -0.36 1.56e-11 Menarche (age at onset); LUSC cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.94 -0.31 7.19e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9400467 0.528 rs17539197 chr6:111769171 C/G cg22127309 chr6:111907043 TRAF3IP2 -0.37 -7.07 -0.36 9.2e-12 Blood metabolite levels;Amino acid levels; LUSC cis rs9815354 0.680 rs73073294 chr3:42028053 A/G cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs9535307 0.615 rs3736830 chr13:50306221 G/C cg04663916 chr13:50265991 EBPL 0.49 6.14 0.32 2.33e-9 Obesity-related traits; LUSC cis rs4363385 0.818 rs9659389 chr1:152989844 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -5.75 -0.3 2e-8 Inflammatory skin disease; LUSC cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg11645453 chr3:52864694 ITIH4 -0.39 -8.95 -0.44 2.56e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg11301795 chr4:187892539 NA -0.8 -15.66 -0.65 7.98e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs1059312 1.000 rs7302634 chr12:129279931 C/T cg09035930 chr12:129282057 SLC15A4 0.76 15.73 0.65 4e-42 Systemic lupus erythematosus; LUSC cis rs354225 0.544 rs3796017 chr2:54807452 T/A cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg22903471 chr2:27725779 GCKR -0.41 -6.85 -0.35 3.6e-11 Total body bone mineral density; LUSC cis rs992157 0.764 rs10932774 chr2:219191569 A/G cg00012203 chr2:219082015 ARPC2 0.57 8.66 0.43 2.05e-16 Colorectal cancer; LUSC cis rs10463316 0.894 rs6891252 chr5:150762807 G/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.56 -0.38 3.88e-13 Metabolite levels (Pyroglutamine); LUSC cis rs2204008 0.657 rs8186888 chr12:38334260 T/G cg13010199 chr12:38710504 ALG10B 0.51 7.61 0.38 2.8e-13 Bladder cancer; LUSC cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 13.25 0.59 1.67e-32 Chronic sinus infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06808467 chr18:5237767 LOC339290;C18orf18 0.48 8.46 0.42 8.21e-16 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg04155289 chr7:94953770 PON1 -0.34 -5.77 -0.3 1.8e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg24633833 chr3:10029261 TMEM111 0.45 5.89 0.31 9.42e-9 Alzheimer's disease; LUSC cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg13010199 chr12:38710504 ALG10B 0.65 9.91 0.48 1.78e-20 Bladder cancer; LUSC cis rs2204008 0.713 rs11173567 chr12:38089375 T/C cg26384229 chr12:38710491 ALG10B 0.85 13.47 0.59 2.51e-33 Bladder cancer; LUSC cis rs734999 0.545 rs7368105 chr1:2556548 C/T cg18932078 chr1:2524107 MMEL1 0.31 6.93 0.35 2.21e-11 Ulcerative colitis; LUSC cis rs116095464 0.558 rs9312957 chr5:202194 C/T cg22496380 chr5:211416 CCDC127 -0.87 -8.93 -0.44 2.83e-17 Breast cancer; LUSC cis rs7172677 1.000 rs55662404 chr15:75432341 G/A cg14664628 chr15:75095509 CSK 0.45 5.79 0.3 1.6e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs11098499 0.780 rs7692994 chr4:120427489 C/A cg24375607 chr4:120327624 NA 0.67 10.2 0.49 1.94e-21 Corneal astigmatism; LUSC cis rs9300255 0.596 rs1568427 chr12:123738678 A/G cg13010344 chr12:123464640 ARL6IP4 -0.48 -7.09 -0.36 8.27e-12 Neutrophil percentage of white cells; LUSC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg07716408 chr11:68623521 NA -0.3 -5.78 -0.3 1.75e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs478607 0.748 rs61884413 chr11:64459406 C/T cg19131476 chr11:64387923 NRXN2 0.33 5.82 0.3 1.35e-8 Urate levels; LUSC cis rs9733 0.566 rs878471 chr1:150547747 G/A cg17724175 chr1:150552817 MCL1 -0.35 -6.13 -0.32 2.45e-9 Tonsillectomy; LUSC cis rs62244186 0.714 rs2293600 chr3:44599103 G/T cg15225532 chr3:44803084 KIF15;KIAA1143 -0.41 -6.17 -0.32 2e-9 Depressive symptoms; LUSC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg18758796 chr5:131593413 PDLIM4 0.41 6.76 0.35 6.13e-11 Breast cancer; LUSC trans rs800082 0.516 rs7611932 chr3:144200593 A/G cg24215973 chr2:240111563 HDAC4 0.45 6.77 0.35 5.79e-11 Smoking behavior; LUSC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg06637938 chr14:75390232 RPS6KL1 0.52 8.33 0.41 2.08e-15 Height; LUSC cis rs3092073 0.617 rs8123864 chr20:44598670 T/C cg23252815 chr20:44420276 WFDC3;DNTTIP1 -0.37 -5.86 -0.31 1.12e-8 Intelligence (multi-trait analysis); LUSC cis rs568617 0.903 rs601863 chr11:65646557 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.51 -6.14 -0.32 2.39e-9 Crohn's disease; LUSC cis rs2180341 0.814 rs6919082 chr6:127737888 T/G cg27446573 chr6:127587934 RNF146 0.71 10.97 0.51 4.17e-24 Breast cancer; LUSC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg10802521 chr3:52805072 NEK4 -0.47 -7.25 -0.37 2.89e-12 Electroencephalogram traits; LUSC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg13390004 chr1:15929781 NA 0.41 6.9 0.35 2.66e-11 Systolic blood pressure; LUSC trans rs11039798 0.512 rs1988465 chr11:49011303 C/T cg03929089 chr4:120376271 NA 0.7 7.63 0.39 2.45e-13 Axial length; LUSC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg14004847 chr7:1930337 MAD1L1 -0.52 -7.88 -0.4 4.66e-14 Bipolar disorder and schizophrenia; LUSC cis rs4654899 0.865 rs10916951 chr1:21528835 A/G cg02927042 chr1:21476669 EIF4G3 0.38 6.13 0.32 2.44e-9 Superior frontal gyrus grey matter volume; LUSC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg19046167 chr17:80928561 B3GNTL1 -0.42 -5.93 -0.31 7.39e-9 Breast cancer; LUSC cis rs7020830 0.931 rs13293916 chr9:37136359 C/G cg14294708 chr9:37120828 ZCCHC7 1.11 24.53 0.8 1.07e-76 Schizophrenia; LUSC trans rs2587949 0.571 rs2600138 chr3:4208596 G/C cg15139668 chr4:4577005 NA -0.41 -5.98 -0.31 5.65e-9 Periodontitis (DPAL); LUSC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 6.97e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.64 0.47 1.44e-19 Personality dimensions; LUSC cis rs6750047 0.567 rs336039 chr2:38258827 C/T cg07380506 chr2:38303506 CYP1B1 -0.4 -5.78 -0.3 1.67e-8 Cutaneous malignant melanoma;Melanoma; LUSC cis rs6967385 0.560 rs55794302 chr7:12351495 C/A cg20607287 chr7:12443886 VWDE 0.5 7.46 0.38 7.34e-13 Response to taxane treatment (placlitaxel); LUSC cis rs9747201 0.926 rs7222764 chr17:80062698 G/A cg17462356 chr17:80056334 FASN 0.45 5.67 0.3 3.17e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs3755132 0.852 rs60319313 chr2:15792803 C/A cg12888861 chr2:15731646 DDX1 0.49 7.11 0.36 7.08e-12 Wilms tumor; LUSC cis rs2242194 0.844 rs11264295 chr1:154987526 C/T cg06221963 chr1:154839813 KCNN3 -0.44 -8.94 -0.44 2.77e-17 Schizophrenia; LUSC cis rs3812762 0.871 rs11042068 chr11:8815599 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -6.23 -0.32 1.39e-9 Hypospadias; LUSC cis rs62034325 0.697 rs710410 chr16:28603342 A/G cg07382826 chr16:28625726 SULT1A1 0.28 6.07 0.32 3.47e-9 Body mass index; LUSC cis rs68170813 0.559 rs12537342 chr7:106943563 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.41 -5.64 -0.3 3.56e-8 Coronary artery disease; LUSC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg04369109 chr6:150039330 LATS1 -0.56 -8.17 -0.41 6.41e-15 Lung cancer; LUSC cis rs2282300 0.739 rs1765133 chr11:30339400 C/T cg25418670 chr11:30344373 C11orf46 -0.64 -9.18 -0.45 4.6e-18 Morning vs. evening chronotype; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg08280861 chr8:58055591 NA 0.52 5.69 0.3 2.76e-8 Developmental language disorder (linguistic errors); LUSC cis rs2067615 0.579 rs1922435 chr12:107082455 A/G cg15890332 chr12:107067104 RFX4 0.35 5.91 0.31 8.22e-9 Heart rate; LUSC cis rs6574644 1.000 rs55744181 chr14:81777794 A/G cg01989461 chr14:81687754 GTF2A1 0.47 5.69 0.3 2.75e-8 Obesity-related traits; LUSC cis rs1577917 0.710 rs1059306 chr6:86388109 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.59 0.43 3.48e-16 Response to antipsychotic treatment; LUSC cis rs892961 0.806 rs35489990 chr17:75412312 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs7586879 0.796 rs916486 chr2:25082629 C/A cg01884057 chr2:25150051 NA 0.39 7.93 0.4 3.42e-14 Body mass index; LUSC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg11764359 chr7:65958608 NA -0.52 -6.81 -0.35 4.44e-11 Aortic root size; LUSC cis rs7954584 0.611 rs3887885 chr12:122336486 C/T cg01765077 chr12:122356316 WDR66 0.51 7.44 0.38 8.68e-13 Mean corpuscular volume; LUSC cis rs62408225 1.000 rs2021716 chr6:90941289 C/T cg06866423 chr6:90926672 BACH2 0.41 5.96 0.31 6.44e-9 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs7939886 0.920 rs7115395 chr11:55877116 G/A cg03929089 chr4:120376271 NA 0.75 6.12 0.32 2.65e-9 Myopia (pathological); LUSC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg11764359 chr7:65958608 NA 0.79 12.72 0.57 1.76e-30 Aortic root size; LUSC cis rs1577917 0.655 rs7766485 chr6:86263555 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 7.08 0.36 8.37e-12 Response to antipsychotic treatment; LUSC cis rs2301436 0.512 rs6925969 chr6:167501738 C/A cg07741184 chr6:167504864 NA 0.45 7.72 0.39 1.38e-13 Crohn's disease; LUSC trans rs4665809 0.878 rs892448 chr2:26366205 A/G cg19249749 chr1:223853145 CAPN8 -0.49 -6.23 -0.32 1.38e-9 Gut microbiome composition (summer); LUSC cis rs3741151 1.000 rs74776668 chr11:73065909 G/A cg17517138 chr11:73019481 ARHGEF17 1.09 9.0 0.44 1.69e-17 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg17211192 chr8:82754475 SNX16 -0.81 -11.22 -0.52 5.06e-25 Diastolic blood pressure; LUSC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg12463550 chr7:65579703 CRCP 0.45 6.73 0.35 7.31e-11 Aortic root size; LUSC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg11247378 chr22:39784982 NA -0.65 -12.51 -0.56 1.02e-29 Intelligence (multi-trait analysis); LUSC cis rs7759001 0.857 rs1022517 chr6:27365009 G/C cg18711553 chr6:27366782 ZNF391 0.39 5.71 0.3 2.48e-8 Glomerular filtration rate (creatinine); LUSC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg21153622 chr11:89784906 NA -0.39 -6.04 -0.31 4.09e-9 HDL cholesterol; LUSC cis rs6582630 0.555 rs34884627 chr12:38443831 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.75e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg11764359 chr7:65958608 NA 0.7 10.89 0.51 7.54e-24 Aortic root size; LUSC cis rs6987853 0.933 rs2923430 chr8:42391195 T/C cg09913449 chr8:42400586 C8orf40 0.49 8.23 0.41 4.31e-15 Mean corpuscular hemoglobin concentration; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg05650458 chr1:228270764 ARF1 0.41 6.79 0.35 5.14e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs12956009 0.518 rs953291 chr18:44870499 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.41 0.33 5.01e-10 Educational attainment (years of education); LUSC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg00310523 chr12:86230176 RASSF9 0.49 9.26 0.45 2.64e-18 Major depressive disorder; LUSC trans rs8002861 0.781 rs7322781 chr13:44442238 T/C cg12856521 chr11:46389249 DGKZ 0.42 6.59 0.34 1.7e-10 Leprosy; LUSC cis rs9905704 0.681 rs4793949 chr17:56571950 C/T cg12560992 chr17:57184187 TRIM37 0.48 5.86 0.31 1.11e-8 Testicular germ cell tumor; LUSC cis rs826838 0.510 rs17523988 chr12:39222785 A/C cg26384229 chr12:38710491 ALG10B 0.78 11.81 0.54 3.85e-27 Heart rate; LUSC cis rs2046867 0.818 rs1502757 chr3:72864161 C/T cg25664220 chr3:72788482 NA -0.7 -11.75 -0.54 6.61e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs4917833 0.789 rs10883100 chr10:100219374 T/A cg19043522 chr10:100227446 HPSE2 0.4 5.71 0.3 2.53e-8 Pediatric bone mineral density (femoral neck); LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg11062466 chr8:58055876 NA 0.71 8.69 0.43 1.62e-16 Developmental language disorder (linguistic errors); LUSC cis rs7954584 0.635 rs11043242 chr12:122356293 G/C cg13699009 chr12:122356056 WDR66 0.49 7.6 0.38 2.95e-13 Mean corpuscular volume; LUSC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg00129232 chr17:37814104 STARD3 -0.55 -8.28 -0.41 3.03e-15 Asthma; LUSC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 10.92 0.51 6.24e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg08677398 chr8:58056175 NA 0.5 6.66 0.34 1.13e-10 Developmental language disorder (linguistic errors); LUSC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC cis rs1808579 0.904 rs2960578 chr18:21143739 A/C cg14672496 chr18:21087552 C18orf8 0.36 6.26 0.32 1.18e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg05025164 chr4:1340916 KIAA1530 0.46 7.06 0.36 9.49e-12 Longevity; LUSC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.58 -9.05 -0.44 1.22e-17 Menarche (age at onset); LUSC cis rs4595586 0.525 rs4450203 chr12:39381493 T/G cg26384229 chr12:38710491 ALG10B 0.49 6.98 0.36 1.57e-11 Morning vs. evening chronotype; LUSC cis rs1577917 0.740 rs6926049 chr6:86266133 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.56 0.42 4.16e-16 Response to antipsychotic treatment; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg22463517 chr17:26988906 SDF2;SUPT6H 0.44 6.28 0.32 1.07e-9 Cognitive function;Information processing speed; LUSC cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg08999081 chr20:33150536 PIGU 0.46 8.24 0.41 3.92e-15 Coronary artery disease; LUSC cis rs7703051 0.513 rs6895057 chr5:74624234 G/A cg00601450 chr5:74908170 NA -0.32 -5.76 -0.3 1.88e-8 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; LUSC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg22907277 chr7:1156413 C7orf50 0.71 10.38 0.49 4.75e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7246657 0.943 rs3745765 chr19:37854235 G/T cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs7267979 1.000 rs447722 chr20:25443510 C/T cg08601574 chr20:25228251 PYGB 0.42 6.41 0.33 4.9e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1395 0.778 rs4665959 chr2:27443256 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.49 7.41 0.38 1.06e-12 Blood metabolite levels; LUSC cis rs1808579 0.904 rs11664076 chr18:21094207 C/T cg14672496 chr18:21087552 C18orf8 0.36 5.96 0.31 6.34e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -7.54 -0.38 4.58e-13 Allergic disease (asthma, hay fever or eczema); LUSC cis rs1865760 1.000 rs2071301 chr6:25914263 G/T cg17691542 chr6:26056736 HIST1H1C 0.47 7.32 0.37 1.83e-12 Height; LUSC trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg23505145 chr19:12996616 KLF1 0.65 11.04 0.52 2.33e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg02753203 chr1:228287806 NA -0.67 -11.67 -0.54 1.3e-26 Diastolic blood pressure; LUSC cis rs2742417 0.603 rs1019129 chr3:45780780 T/C cg10512202 chr3:45649293 LIMD1 0.36 6.11 0.32 2.71e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs3755397 1 rs3755397 chr2:242294913 A/G cg03294028 chr2:242255774 SEPT2;HDLBP -0.65 -5.83 -0.3 1.34e-8 Chronic lymphocytic leukemia;Eosinophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; LUSC cis rs9916302 0.706 rs2879259 chr17:37410892 C/G cg07936489 chr17:37558343 FBXL20 -0.8 -10.24 -0.49 1.4e-21 Glomerular filtration rate (creatinine); LUSC cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs1478897 0.804 rs9329246 chr8:11392880 A/G cg15556689 chr8:8085844 FLJ10661 0.44 6.24 0.32 1.31e-9 Systemic lupus erythematosus; LUSC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg09165964 chr15:75287851 SCAMP5 0.45 6.76 0.35 6.05e-11 Breast cancer; LUSC trans rs56176327 0.532 rs9849038 chr3:49771990 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.59 -7.01 -0.36 1.29e-11 Intelligence (multi-trait analysis); LUSC cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs929354 0.772 rs1182360 chr7:157020550 C/G cg05182265 chr7:156933206 UBE3C -0.58 -9.33 -0.45 1.49e-18 Body mass index; LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.51 0.46 3.9e-19 Bipolar disorder; LUSC cis rs6426558 0.537 rs2670462 chr1:227432923 C/G cg10327440 chr1:227177885 CDC42BPA -0.52 -7.05 -0.36 1.04e-11 Neutrophil percentage of white cells; LUSC cis rs10782582 0.609 rs78556436 chr1:76352875 G/A cg10523679 chr1:76189770 ACADM -0.43 -6.19 -0.32 1.81e-9 Daytime sleep phenotypes; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06463913 chr11:207296 BET1L;RIC8A -0.49 -6.06 -0.31 3.61e-9 Bipolar disorder and schizophrenia; LUSC cis rs908922 0.676 rs12059256 chr1:152515431 G/A cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs9527 0.590 rs12775302 chr10:104911356 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.75 0.47 6.31e-20 Arsenic metabolism; LUSC cis rs225245 0.791 rs7216391 chr17:34024706 G/A cg05299278 chr17:33885742 SLFN14 0.29 6.44 0.33 4.09e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs1215050 0.740 rs6855827 chr4:99065706 G/A cg05340658 chr4:99064831 C4orf37 0.45 7.29 0.37 2.33e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7527798 0.592 rs1323720 chr1:207823161 T/C cg09232269 chr1:207846808 CR1L -0.3 -6.46 -0.33 3.78e-10 Erythrocyte sedimentation rate; LUSC cis rs17270561 0.609 rs9379789 chr6:25745579 A/G cg16482183 chr6:26056742 HIST1H1C 0.64 9.14 0.45 6.03e-18 Iron status biomarkers; LUSC cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.93 -0.31 7.4e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg04362960 chr10:104952993 NT5C2 0.6 9.44 0.46 6.82e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg13902645 chr11:5959945 NA -0.62 -9.31 -0.45 1.76e-18 DNA methylation (variation); LUSC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.57 -7.0 -0.36 1.43e-11 Lung function (FEV1/FVC); LUSC cis rs68170813 0.522 rs12154818 chr7:107074515 G/C cg02696742 chr7:106810147 HBP1 -0.46 -6.43 -0.33 4.3e-10 Coronary artery disease; LUSC cis rs9325144 0.554 rs1906264 chr12:38739490 A/G cg26384229 chr12:38710491 ALG10B 0.6 9.51 0.46 3.96e-19 Morning vs. evening chronotype; LUSC trans rs11098499 0.954 rs17046116 chr4:120387259 G/A cg25214090 chr10:38739885 LOC399744 0.58 8.45 0.42 9.1e-16 Corneal astigmatism; LUSC cis rs7954584 0.567 rs11043233 chr12:122330733 C/T cg13699009 chr12:122356056 WDR66 0.49 7.72 0.39 1.37e-13 Mean corpuscular volume; LUSC cis rs754466 0.724 rs11002318 chr10:79633807 G/A cg17075019 chr10:79541650 NA -0.76 -12.18 -0.55 1.73e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7178375 0.607 rs12903674 chr15:31194552 G/C cg01738805 chr15:31195741 MTMR15 0.87 7.07 0.36 9.2e-12 Hypertriglyceridemia; LUSC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.52 0.34 2.6200000000000003e-10 Bipolar disorder; LUSC cis rs10950821 0.530 rs6950237 chr7:20688135 G/A cg02470904 chr7:20686108 ABCB5 0.33 5.89 0.31 9.35e-9 Response to statin therapy; LUSC cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg12310025 chr6:25882481 NA -0.5 -9.07 -0.44 1.03e-17 Blood metabolite levels; LUSC cis rs10489525 0.583 rs12034918 chr1:115626285 C/T cg01522456 chr1:115632236 TSPAN2 0.62 8.69 0.43 1.6e-16 Autism; LUSC cis rs4704187 0.640 rs74719230 chr5:74431888 G/C cg03227963 chr5:74354835 NA 0.32 6.89 0.35 2.86e-11 Response to amphetamines; LUSC cis rs11608355 0.545 rs4766474 chr12:109908084 G/C cg05360138 chr12:110035743 NA 0.89 11.55 0.53 3.47e-26 Neuroticism; LUSC cis rs6906287 0.647 rs11153767 chr6:118960519 C/T cg21191810 chr6:118973309 C6orf204 0.32 6.01 0.31 4.89e-9 Electrocardiographic conduction measures; LUSC cis rs4474465 0.688 rs7124803 chr11:78280822 T/G cg27205649 chr11:78285834 NARS2 0.58 7.2 0.37 4.1e-12 Alzheimer's disease (survival time); LUSC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC trans rs7951105 1.000 rs1906683 chr11:39254840 C/A cg24085930 chr3:21832523 NA 0.48 6.02 0.31 4.72e-9 Free thyroxine concentration; LUSC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg24578937 chr1:2090814 PRKCZ 0.45 10.11 0.48 4e-21 Height; LUSC cis rs3790645 1.000 rs282177 chr1:26899125 C/T cg17456097 chr1:26900765 RPS6KA1 0.44 6.83 0.35 4.05e-11 Glucose homeostasis traits; LUSC trans rs236907 0.859 rs35674909 chr1:171778147 G/A cg13482142 chr2:234261155 NA 0.5 6.13 0.32 2.54e-9 Mean platelet volume; LUSC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg22875332 chr1:76189707 ACADM 0.86 14.01 0.61 2.16e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs5753618 0.561 rs4820043 chr22:31647094 A/G cg22777020 chr22:31556080 RNF185 -0.47 -6.06 -0.31 3.64e-9 Colorectal cancer; LUSC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.73 0.47 7.16e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg02034447 chr16:89574710 SPG7 0.44 6.57 0.34 1.95e-10 Multiple myeloma (IgH translocation); LUSC cis rs1018836 0.608 rs11997663 chr8:91474484 A/C cg16814680 chr8:91681699 NA -0.56 -8.02 -0.4 1.86e-14 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7582180 0.629 rs2309798 chr2:100956949 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.41 -0.42 1.19e-15 Intelligence (multi-trait analysis); LUSC cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.51 -5.76 -0.3 1.9e-8 Glomerular filtration rate in chronic kidney disease; LUSC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg24675658 chr1:53192096 ZYG11B 0.61 9.69 0.47 9.89e-20 Monocyte count; LUSC cis rs11997175 0.603 rs6468205 chr8:33778642 T/A ch.8.33884649F chr8:33765107 NA 0.41 6.15 0.32 2.21e-9 Body mass index; LUSC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg25456477 chr12:86230367 RASSF9 0.35 6.16 0.32 2.14e-9 Major depressive disorder; LUSC cis rs3093024 0.874 rs3093018 chr6:167539805 C/T cg07741184 chr6:167504864 NA -0.4 -7.24 -0.37 3.1e-12 Rheumatoid arthritis; LUSC trans rs724744 0.742 rs1008200 chr6:22360741 A/G cg13807341 chr11:118445984 ARCN1 -0.35 -5.97 -0.31 6.14e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs11098499 0.954 rs71614438 chr4:120371252 G/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs7804356 0.954 rs3801831 chr7:26853470 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.95e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg18252515 chr7:66147081 NA -0.57 -7.89 -0.4 4.26e-14 Corneal structure; LUSC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg08847533 chr14:75593920 NEK9 -0.83 -15.07 -0.64 1.56e-39 Height; LUSC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg11742103 chr11:62369870 EML3;MTA2 0.53 8.75 0.43 1.1e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7215564 0.908 rs7503757 chr17:78685599 A/G cg04008703 chr7:27280585 NA -0.39 -5.97 -0.31 6.18e-9 Myopia (pathological); LUSC cis rs79839061 0.666 rs62297063 chr4:869708 G/A cg23992470 chr4:843637 GAK 0.6 6.4 0.33 5.14e-10 Intelligence (multi-trait analysis); LUSC cis rs1577917 0.655 rs9359658 chr6:86305769 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.48 7.8 0.39 7.8e-14 Response to antipsychotic treatment; LUSC cis rs13394619 0.565 rs12478958 chr2:11748037 A/G cg07314298 chr2:11723111 GREB1 -0.39 -6.69 -0.34 9.37e-11 Endometriosis; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg06877462 chr1:205807181 PM20D1 0.5 8.87 0.44 4.39e-17 Menarche (age at onset); LUSC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg02423579 chr7:2872169 GNA12 -0.46 -6.62 -0.34 1.43e-10 Height; LUSC trans rs12310956 0.532 rs10844720 chr12:33987859 G/T cg26384229 chr12:38710491 ALG10B 0.7 10.83 0.51 1.22e-23 Morning vs. evening chronotype; LUSC cis rs6690583 0.697 rs2012369 chr1:85520845 T/C cg11262906 chr1:85462892 MCOLN2 -0.57 -7.31 -0.37 2.01e-12 Serum sulfate level; LUSC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg08680598 chr22:49984980 NA -0.33 -6.02 -0.31 4.48e-9 Monocyte count;Monocyte percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00754232 chr7:97881723 TECPR1 -0.43 -6.51 -0.34 2.68e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9837602 0.938 rs34922392 chr3:99794730 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.5 6.32 0.33 8.6e-10 Breast cancer; LUSC cis rs765787 0.530 rs2554455 chr15:45521304 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.82 -0.43 6.5e-17 Uric acid levels; LUSC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg02574844 chr11:5959923 NA -0.39 -6.13 -0.32 2.42e-9 DNA methylation (variation); LUSC cis rs7819412 0.668 rs920047 chr8:11087475 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.89 -0.31 9.39e-9 Triglycerides; LUSC cis rs7582720 1.000 rs75324925 chr2:203698300 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.73 0.43 1.22e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg27129171 chr3:47204927 SETD2 0.76 13.78 0.6 1.56e-34 Colorectal cancer; LUSC trans rs62238980 0.614 rs76142630 chr22:32392177 A/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC cis rs11931598 1.000 rs11931598 chr4:7047102 A/G cg26116260 chr4:7069785 GRPEL1 0.46 6.59 0.34 1.76e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs4843185 0.669 rs4843506 chr16:85715440 T/A cg05245094 chr16:85669572 KIAA0182 0.39 5.75 0.3 2.07e-8 Platelet distribution width; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg05025164 chr4:1340916 KIAA1530 -0.42 -6.39 -0.33 5.73e-10 Obesity-related traits; LUSC cis rs7577851 0.715 rs56175187 chr2:69620650 G/C cg10773587 chr2:69614142 GFPT1 0.58 6.48 0.33 3.24e-10 Parkinson's disease (age of onset); LUSC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.76 -0.39 1.08e-13 Prostate cancer (SNP x SNP interaction); LUSC cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.46 -5.75 -0.3 2.02e-8 Schizophrenia; LUSC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.7 0.34 8.78e-11 Melanoma; LUSC trans rs9393777 0.920 rs41269265 chr6:27425349 T/C cg01620082 chr3:125678407 NA -0.81 -7.4 -0.38 1.12e-12 Intelligence (multi-trait analysis); LUSC cis rs16866061 0.962 rs72972361 chr2:225341550 G/A cg12698349 chr2:225449008 CUL3 0.86 14.3 0.62 1.57e-36 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -8.18 -0.41 6.18e-15 Axial length; LUSC cis rs6545883 0.894 rs9677047 chr2:61585295 C/G cg15711740 chr2:61764176 XPO1 0.44 6.75 0.35 6.5500000000000006e-11 Tuberculosis; LUSC cis rs394563 0.559 rs7753269 chr6:149671360 G/A cg03678062 chr6:149772716 ZC3H12D 0.3 6.18 0.32 1.9e-9 Dupuytren's disease; LUSC cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg00071950 chr4:10020882 SLC2A9 -0.5 -8.43 -0.42 1.08e-15 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs702885 0.655 rs702907 chr2:65766983 T/C cg06379192 chr1:3157287 PRDM16 -0.73 -6.18 -0.32 1.92e-9 Electroencephalogram traits; LUSC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg11663144 chr21:46675770 NA -0.41 -7.05 -0.36 1.04e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg03233332 chr7:66118400 NA -0.41 -5.99 -0.31 5.54e-9 Aortic root size; LUSC cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg06671706 chr8:8559999 CLDN23 0.49 6.57 0.34 1.94e-10 Obesity-related traits; LUSC trans rs2392780 0.536 rs631845 chr8:128338760 G/A cg10897648 chr18:56338258 MALT1 -0.42 -6.35 -0.33 6.95e-10 Breast cancer (early onset); LUSC cis rs4566357 1.000 rs6721237 chr2:227923357 T/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.75 -0.3 1.97e-8 Coronary artery disease; LUSC cis rs713587 0.521 rs6545766 chr2:25077856 C/T cg15423357 chr2:25149977 NA 0.3 5.66 0.3 3.24e-8 Body mass index in non-asthmatics; LUSC cis rs807669 0.525 rs9605955 chr22:19181557 C/T cg02655711 chr22:19163373 SLC25A1 0.5 9.04 0.44 1.32e-17 Metabolite levels; LUSC cis rs2273669 0.667 rs12215736 chr6:109330367 A/G cg05315195 chr6:109294784 ARMC2 -0.53 -5.89 -0.31 9.28e-9 Prostate cancer; LUSC cis rs941898 0.957 rs3783332 chr14:100586757 A/G cg26002632 chr14:100625216 DEGS2 -0.36 -6.63 -0.34 1.32e-10 White matter hyperintensity burden; LUSC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg04455712 chr21:45112962 RRP1B 0.44 8.38 0.42 1.47e-15 Mean corpuscular volume; LUSC cis rs2124969 0.562 rs6750639 chr2:161066862 T/C cg03641300 chr2:160917029 PLA2R1 -0.43 -7.03 -0.36 1.17e-11 Waist circumference adjusted for body mass index; LUSC cis rs17102423 0.588 rs7150646 chr14:65540463 G/T cg11161011 chr14:65562177 MAX -0.71 -10.9 -0.51 7.03e-24 Obesity-related traits; LUSC cis rs854765 0.647 rs854767 chr17:18018263 A/C cg09796270 chr17:17721594 SREBF1 -0.34 -5.76 -0.3 1.88e-8 Total body bone mineral density; LUSC cis rs2279817 0.863 rs2270976 chr1:18023690 A/G cg21791023 chr1:18019539 ARHGEF10L 0.46 6.32 0.33 8.57e-10 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06258179 chr7:92463261 CDK6 0.42 6.19 0.32 1.81e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7264396 0.887 rs6060434 chr20:34068382 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.26 -0.32 1.19e-9 Total cholesterol levels; LUSC cis rs55728055 0.661 rs62237791 chr22:31973124 A/G cg01338084 chr22:32026380 PISD 0.93 6.78 0.35 5.4e-11 Age-related hearing impairment; LUSC cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg09479241 chr17:27052676 TLCD1 0.44 5.89 0.31 9.58e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg02564969 chr6:151773285 C6orf211;RMND1 0.45 6.52 0.34 2.6200000000000003e-10 Menarche (age at onset); LUSC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.43 0.38 9.18e-13 Menarche (age at onset); LUSC cis rs7172677 0.793 rs8029712 chr15:75418170 T/A cg14664628 chr15:75095509 CSK -0.45 -5.79 -0.3 1.66e-8 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs17253792 0.822 rs10147380 chr14:56054354 T/C cg01858014 chr14:56050164 KTN1 -0.86 -7.18 -0.37 4.47e-12 Putamen volume; LUSC cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg03264133 chr6:25882463 NA -0.5 -9.15 -0.45 5.74e-18 Blood metabolite levels; LUSC cis rs11637445 0.589 rs4776989 chr15:68130684 T/C cg08079166 chr15:68083412 MAP2K5 0.35 7.28 0.37 2.37e-12 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg06873352 chr17:61820015 STRADA -0.6 -10.31 -0.49 8.18e-22 Prudent dietary pattern; LUSC cis rs9527 0.590 rs10509766 chr10:104926334 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.41 -0.33 4.97e-10 Arsenic metabolism; LUSC trans rs890100 0.800 rs7580549 chr2:56759547 A/G cg01657744 chr10:88471748 LDB3 0.44 6.11 0.32 2.79e-9 Gut microbiome composition (summer); LUSC cis rs4654899 0.965 rs7525620 chr1:21458392 G/A cg01072550 chr1:21505969 NA -0.55 -8.41 -0.42 1.18e-15 Superior frontal gyrus grey matter volume; LUSC cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg08999081 chr20:33150536 PIGU -0.51 -10.3 -0.49 8.65e-22 Glomerular filtration rate (creatinine); LUSC cis rs72772090 0.539 rs13601 chr5:96110596 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.74 -7.49 -0.38 6.25e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg14789911 chr21:47582049 C21orf56 0.42 6.58 0.34 1.8e-10 Testicular germ cell tumor; LUSC cis rs6693567 0.545 rs12049177 chr1:150474337 G/A cg15654264 chr1:150340011 RPRD2 0.46 7.5 0.38 5.73e-13 Migraine; LUSC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg17366294 chr4:99064904 C4orf37 0.6 10.61 0.5 7.4e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg07636037 chr3:49044803 WDR6 1.03 18.02 0.7 3.34e-51 Parkinson's disease; LUSC cis rs9611519 0.929 rs12484971 chr22:41439304 A/T cg03806693 chr22:41940476 POLR3H -0.54 -7.3 -0.37 2.11e-12 Neuroticism; LUSC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg01448562 chr3:133502909 NA -0.66 -10.57 -0.5 1.03e-22 Iron status biomarkers; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02400128 chr5:114849010 NA 0.48 6.1 0.32 2.99e-9 Bipolar disorder and schizophrenia; LUSC cis rs478304 0.651 rs11604451 chr11:65551710 C/T cg05805236 chr11:65401703 PCNXL3 -0.55 -8.73 -0.43 1.2e-16 Acne (severe); LUSC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg18404041 chr3:52824283 ITIH1 -0.51 -9.75 -0.47 6.37e-20 Bipolar disorder; LUSC cis rs9811920 0.690 rs7623587 chr3:99906751 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.35 6.64 0.34 1.26e-10 Axial length; LUSC cis rs597583 0.715 rs7936795 chr11:117391736 A/G cg27161313 chr11:117392002 DSCAML1 -0.51 -8.45 -0.42 9.26e-16 Putamen volume; LUSC cis rs17401966 0.558 rs17402762 chr1:10414470 T/C cg17425144 chr1:10567563 PEX14 -0.34 -6.08 -0.32 3.19e-9 Hepatocellular carcinoma; LUSC cis rs7681440 0.626 rs6812593 chr4:90817991 C/T cg15133208 chr4:90757351 SNCA -0.35 -5.94 -0.31 7.19e-9 Dementia with Lewy bodies; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12684360 chr13:50367057 KPNA3 0.47 6.33 0.33 8.02e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 17.04 0.68 2.72e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.99 -0.31 5.52e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg17143192 chr8:8559678 CLDN23 0.63 9.28 0.45 2.18e-18 Obesity-related traits; LUSC cis rs73198271 0.563 rs3748143 chr8:8655237 A/G cg01851573 chr8:8652454 MFHAS1 -0.65 -8.98 -0.44 1.99e-17 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9359856 0.673 rs2039053 chr6:90303760 G/A cg13799429 chr6:90582589 CASP8AP2 0.75 8.08 0.4 1.19e-14 Bipolar disorder; LUSC cis rs6547741 0.935 rs12714204 chr2:27787540 T/C cg27432699 chr2:27873401 GPN1 0.83 15.57 0.65 1.81e-41 Oral cavity cancer; LUSC cis rs2012796 0.665 rs72703728 chr14:81834523 G/A cg02996355 chr14:81879375 NA 0.57 8.3 0.41 2.65e-15 Night sleep phenotypes; LUSC cis rs259282 0.519 rs259276 chr19:33160953 C/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 1.03 14.66 0.63 6.46e-38 Schizophrenia; LUSC cis rs72781680 0.851 rs12612830 chr2:24134599 C/T cg08917208 chr2:24149416 ATAD2B 0.91 10.2 0.49 1.91e-21 Lymphocyte counts; LUSC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg02807482 chr3:125708958 NA -0.52 -6.51 -0.34 2.69e-10 Blood pressure (smoking interaction); LUSC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg06022373 chr22:39101656 GTPBP1 0.78 12.16 0.55 2.1e-28 Menopause (age at onset); LUSC cis rs1595825 0.945 rs73056883 chr2:198824638 A/G cg10547527 chr2:198650123 BOLL -0.51 -5.97 -0.31 6.08e-9 Ulcerative colitis; LUSC cis rs2970818 0.831 rs2909381 chr12:4606527 T/C cg11146114 chr12:4671731 NA -0.58 -5.9 -0.31 9.04e-9 Phosphorus levels; LUSC trans rs6089829 0.962 rs4586690 chr20:61658595 G/T cg17470723 chr8:74884337 TCEB1 0.5 7.38 0.37 1.23e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs8060686 0.565 rs8044328 chr16:68146859 G/C cg26727032 chr16:67993705 SLC12A4 -0.42 -5.79 -0.3 1.62e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs747782 0.582 rs11039571 chr11:48207259 G/A cg15704280 chr7:45808275 SEPT13 0.7 6.64 0.34 1.28e-10 Intraocular pressure; LUSC trans rs561341 0.824 rs1978115 chr17:30220776 A/C cg20587970 chr11:113659929 NA -1.08 -13.25 -0.59 1.76e-32 Hip circumference adjusted for BMI; LUSC cis rs896854 0.738 rs481887 chr8:95967838 A/G cg13393036 chr8:95962371 TP53INP1 0.44 8.67 0.43 1.87e-16 Type 2 diabetes; LUSC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg22029157 chr1:209979665 IRF6 0.81 10.48 0.5 2.07e-22 Cleft lip with or without cleft palate; LUSC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.68 -0.43 1.82e-16 Lung cancer; LUSC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.54 -7.7 -0.39 1.6e-13 Gut microbiome composition (summer); LUSC cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg24692254 chr21:30365293 RNF160 0.92 19.53 0.73 3.38e-57 Dental caries; LUSC cis rs3126085 0.877 rs4456098 chr1:152176034 C/T cg26876637 chr1:152193138 HRNR 0.45 6.46 0.33 3.74e-10 Atopic dermatitis; LUSC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg05669848 chr5:237993 SDHA 0.51 5.72 0.3 2.43e-8 Breast cancer; LUSC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg10351095 chr21:47802916 PCNT 0.42 5.97 0.31 6.16e-9 Testicular germ cell tumor; LUSC cis rs4243830 0.737 rs4908909 chr1:6599041 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -9.64 -0.47 1.4e-19 Body mass index; LUSC cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg26384229 chr12:38710491 ALG10B 0.89 14.89 0.63 8.25e-39 Bladder cancer; LUSC cis rs6504340 0.739 rs4793589 chr17:46667863 G/C cg09704116 chr17:46666958 LOC404266 -0.37 -5.66 -0.3 3.18e-8 Primary tooth development (number of teeth); LUSC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg08219700 chr8:58056026 NA 0.69 8.22 0.41 4.58e-15 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg00945038 chr17:61921165 SMARCD2 0.53 9.35 0.46 1.3e-18 Prudent dietary pattern; LUSC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg19346786 chr7:2764209 NA -0.41 -7.3 -0.37 2.1e-12 Height; LUSC cis rs7100689 0.646 rs2095994 chr10:82127956 G/A cg01528321 chr10:82214614 TSPAN14 0.86 13.15 0.58 4.23e-32 Post bronchodilator FEV1; LUSC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg06634786 chr22:41940651 POLR3H -0.57 -6.86 -0.35 3.34e-11 Vitiligo; LUSC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 7.87 0.4 4.88e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9929218 0.954 rs35444713 chr16:68824492 C/T cg02972257 chr16:68554789 NA 0.42 5.7 0.3 2.62e-8 Colorectal cancer; LUSC trans rs11088226 0.598 rs79634586 chr21:33959363 A/G cg09050820 chr6:167586206 TCP10L2 0.75 9.54 0.46 3.22e-19 Gastritis; LUSC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg06238570 chr21:40685208 BRWD1 -0.49 -7.56 -0.38 3.82e-13 Menarche (age at onset); LUSC cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg03647239 chr10:116582469 FAM160B1 0.47 7.59 0.38 3.26e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg07507251 chr3:52567010 NT5DC2 0.33 6.46 0.33 3.6e-10 Bipolar disorder; LUSC trans rs1997103 0.871 rs9649855 chr7:55410222 T/C cg20935933 chr6:143382018 AIG1 0.5 7.28 0.37 2.42e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs3733418 0.929 rs12507869 chr4:165895674 T/C cg08992305 chr4:165878219 TRIM61;C4orf39 -0.49 -5.83 -0.3 1.31e-8 Obesity-related traits; LUSC cis rs1823874 0.581 rs12905599 chr15:100339938 C/T cg16400843 chr15:100339927 C15orf51 0.4 7.41 0.38 1.07e-12 IgG glycosylation; LUSC cis rs7474896 0.583 rs34185758 chr10:37990854 T/C cg25427524 chr10:38739819 LOC399744 -0.51 -6.84 -0.35 3.76e-11 Obesity (extreme); LUSC cis rs3772130 0.926 rs13072767 chr3:121504098 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.7 10.3 0.49 8.97e-22 Cognitive performance; LUSC cis rs727505 0.721 rs17327715 chr7:124760611 G/C cg23710748 chr7:124431027 NA -0.39 -6.93 -0.35 2.19e-11 Lewy body disease; LUSC cis rs1018836 0.828 rs10956730 chr8:91597428 T/G cg16814680 chr8:91681699 NA -0.7 -11.47 -0.53 6.95e-26 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs11532322 1 rs11532322 chr12:123731423 A/G cg05973401 chr12:123451056 ABCB9 0.52 7.1 0.36 7.72e-12 Schizophrenia; LUSC cis rs12421382 0.659 rs12417251 chr11:109386273 G/T cg16359550 chr11:109292809 C11orf87 0.37 6.46 0.33 3.74e-10 Schizophrenia; LUSC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg15605315 chr1:45957053 TESK2 -0.49 -7.99 -0.4 2.18e-14 High light scatter reticulocyte count; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg11235426 chr6:292522 DUSP22 -0.45 -6.73 -0.35 7.19e-11 Menopause (age at onset); LUSC cis rs9942416 0.533 rs12109251 chr5:75024240 C/A cg19683494 chr5:74908142 NA 0.5 6.82 0.35 4.34e-11 Age-related disease endophenotypes; LUSC trans rs8072100 0.967 rs9894905 chr17:45485982 C/T cg03886242 chr7:26192032 NFE2L3 -0.36 -6.04 -0.31 4.07e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg27279351 chr12:120934652 DYNLL1 0.56 7.48 0.38 6.63e-13 High light scatter reticulocyte count; LUSC cis rs796364 0.760 rs55906940 chr2:201049386 A/G cg23649088 chr2:200775458 C2orf69 -0.56 -6.67 -0.34 1.07e-10 Schizophrenia; LUSC cis rs41271473 0.898 rs3738073 chr1:228871693 C/T cg16512390 chr1:228756714 NA 0.5 5.98 0.31 5.73e-9 Chronic lymphocytic leukemia; LUSC cis rs929596 0.603 rs2602363 chr2:234520525 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.37 -0.33 6.31e-10 Total bilirubin levels in HIV-1 infection; LUSC cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg06064525 chr11:970664 AP2A2 -0.48 -10.3 -0.49 8.59e-22 Alzheimer's disease (late onset); LUSC cis rs2439831 0.867 rs3809481 chr15:43662829 G/A cg02155558 chr15:43621948 ADAL;LCMT2 1.05 12.37 0.56 3.51e-29 Lung cancer in ever smokers; LUSC cis rs1670533 0.769 rs6814833 chr4:1057679 A/C cg27284194 chr4:1044797 NA 0.6 8.85 0.44 5.26e-17 Recombination rate (females); LUSC cis rs10927875 0.619 rs2102664 chr1:16130169 A/G cg22431228 chr1:16359049 CLCNKA 0.32 6.42 0.33 4.6e-10 Dilated cardiomyopathy; LUSC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg16339924 chr4:17578868 LAP3 0.58 8.86 0.44 4.79e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4332037 0.539 rs55993248 chr7:2071132 A/G cg11693508 chr17:37793320 STARD3 0.51 6.12 0.32 2.69e-9 Bipolar disorder; LUSC cis rs478304 0.651 rs12225620 chr11:65505448 T/C cg27068330 chr11:65405492 SIPA1 -0.77 -11.03 -0.52 2.43e-24 Acne (severe); LUSC cis rs1568889 0.667 rs16917914 chr11:28459909 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.47 6.42 0.33 4.81e-10 Bipolar disorder; LUSC cis rs11122272 0.735 rs2486746 chr1:231497324 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.62 -9.72 -0.47 7.91e-20 Hemoglobin concentration; LUSC trans rs7824557 0.564 rs2043508 chr8:11227406 G/A cg06636001 chr8:8085503 FLJ10661 -0.57 -8.5 -0.42 6.35e-16 Retinal vascular caliber; LUSC cis rs2832077 0.943 rs2832094 chr21:30165910 G/A cg08807101 chr21:30365312 RNF160 -0.51 -6.54 -0.34 2.34e-10 Cognitive test performance; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10024484 chr20:20435885 RALGAPA2 -0.71 -6.64 -0.34 1.24e-10 Cognitive performance; LUSC cis rs9443645 0.507 rs1876389 chr6:79481932 A/T cg05283184 chr6:79620031 NA -0.39 -7.25 -0.37 2.83e-12 Intelligence (multi-trait analysis); LUSC cis rs921968 0.541 rs490483 chr2:219429052 A/T cg02176678 chr2:219576539 TTLL4 0.75 14.67 0.63 5.88e-38 Mean corpuscular hemoglobin concentration; LUSC cis rs3768617 0.591 rs9787073 chr1:182974328 T/C ch.1.3577855R chr1:183094577 LAMC1 0.59 8.32 0.41 2.23e-15 Fuchs's corneal dystrophy; LUSC cis rs6686643 0.762 rs6672982 chr1:165612815 T/A cg16553119 chr1:165599451 MGST3 -0.46 -6.48 -0.33 3.32e-10 Total ventricular volume; LUSC cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg08807101 chr21:30365312 RNF160 0.71 11.23 0.52 4.73e-25 Selective IgA deficiency; LUSC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg07636037 chr3:49044803 WDR6 1.05 19.01 0.72 3.89e-55 Parkinson's disease; LUSC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg17376030 chr22:41985996 PMM1 0.48 6.03 0.31 4.25e-9 Vitiligo; LUSC cis rs4363385 0.693 rs10788849 chr1:152902240 C/A cg07796016 chr1:152779584 LCE1C -0.46 -6.57 -0.34 1.98e-10 Inflammatory skin disease; LUSC cis rs12148477 0.787 rs8031311 chr15:51654731 G/T cg25905881 chr15:51634250 GLDN 0.35 5.74 0.3 2.15e-8 Follicule stimulating hormone; LUSC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.54e-10 Menopause (age at onset); LUSC cis rs7119 0.700 rs4886883 chr15:77888924 C/T cg27398640 chr15:77910606 LINGO1 -0.35 -8.26 -0.41 3.56e-15 Type 2 diabetes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03262077 chr1:109505986 CLCC1 0.42 6.4 0.33 5.15e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4285028 0.699 rs2689285 chr3:121586486 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.78 10.73 0.51 2.87e-23 Multiple sclerosis; LUSC cis rs1003719 0.737 rs9974374 chr21:38479885 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.24 0.52 4.47e-25 Eye color traits; LUSC cis rs6504663 0.525 rs557 chr17:48563234 C/T cg03168497 chr17:48586147 MYCBPAP 0.49 6.55 0.34 2.23e-10 Visceral fat; LUSC cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.67e-12 Motion sickness; LUSC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg08847533 chr14:75593920 NEK9 -0.84 -15.5 -0.65 3.28e-41 Height; LUSC cis rs7336332 0.547 rs9581859 chr13:28035147 A/T cg22138327 chr13:27999177 GTF3A 0.76 7.85 0.39 5.72e-14 Weight; LUSC cis rs11997175 0.583 rs7824990 chr8:33779934 A/G ch.8.33884649F chr8:33765107 NA 0.44 6.44 0.33 4.13e-10 Body mass index; LUSC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg11645453 chr3:52864694 ITIH4 0.59 14.13 0.61 7.16e-36 Schizophrenia; LUSC cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 8.64 0.43 2.37e-16 Menarche (age at onset); LUSC cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg14582100 chr15:45693742 SPATA5L1 0.6 10.95 0.51 4.7e-24 Homoarginine levels; LUSC cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.3 -5.85 -0.3 1.16e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs1005224 0.853 rs61980778 chr14:76151532 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 0.68 9.2 0.45 4.01e-18 Large artery stroke; LUSC cis rs6430585 0.528 rs309165 chr2:136667301 T/C cg07169764 chr2:136633963 MCM6 1.04 16.65 0.67 9.21e-46 Corneal structure; LUSC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg15704280 chr7:45808275 SEPT13 -1.02 -19.51 -0.73 4.09e-57 Height; LUSC cis rs7568458 0.837 rs35565292 chr2:85790316 T/A cg17127132 chr2:85788382 GGCX 0.5 7.82 0.39 7.15e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1387259 0.839 rs7487682 chr12:48579665 A/C cg04545296 chr12:48745243 ZNF641 -0.31 -5.97 -0.31 6.13e-9 Obstructive sleep apnea trait (apnea hypopnea index); LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg20887711 chr4:1340912 KIAA1530 0.51 7.75 0.39 1.09e-13 Obesity-related traits; LUSC cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg20283391 chr11:68216788 NA -0.58 -8.21 -0.41 4.89e-15 Total body bone mineral density; LUSC cis rs79387448 0.638 rs74731686 chr2:103043981 G/A cg09003973 chr2:102972529 NA 0.98 9.9 0.48 1.99e-20 Gut microbiota (bacterial taxa); LUSC cis rs868036 0.718 rs3784710 chr15:68072458 T/C cg27219399 chr15:67835830 MAP2K5 0.35 5.67 0.3 3.11e-8 Restless legs syndrome; LUSC trans rs7615952 0.546 rs2922197 chr3:125322032 G/A cg07211511 chr3:129823064 LOC729375 -0.55 -6.07 -0.32 3.38e-9 Blood pressure (smoking interaction); LUSC cis rs983392 0.679 rs654415 chr11:60013674 G/A cg20284999 chr11:59952153 MS4A6A 0.38 6.44 0.33 4.23e-10 Alzheimer's disease (late onset); LUSC trans rs208515 0.518 rs12209790 chr6:66662965 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.03 14.08 0.61 1.14e-35 Exhaled nitric oxide levels; LUSC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg05855489 chr10:104503620 C10orf26 -0.68 -10.15 -0.49 2.8e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg27532560 chr4:187881888 NA -0.38 -6.1 -0.32 2.99e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs11608355 0.545 rs55902232 chr12:109902305 G/A cg05360138 chr12:110035743 NA 0.91 11.65 0.54 1.48e-26 Neuroticism; LUSC cis rs2692947 0.740 rs60452119 chr2:96420050 T/C cg23100626 chr2:96804247 ASTL 0.26 6.38 0.33 6.08e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg22920501 chr2:26401640 FAM59B -0.73 -10.2 -0.49 1.92e-21 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs561341 1.000 rs498391 chr17:30328704 G/A cg20587970 chr11:113659929 NA -1.31 -18.25 -0.71 4.34e-52 Hip circumference adjusted for BMI; LUSC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.41 -5.66 -0.3 3.25e-8 Gut microbiome composition (summer); LUSC cis rs3820928 0.935 rs10203363 chr2:227896976 C/T cg11843606 chr2:227700838 RHBDD1 -0.53 -7.73 -0.39 1.25e-13 Pulmonary function; LUSC cis rs3815700 1.000 rs8109768 chr19:33095463 A/G cg02997394 chr19:33096574 ANKRD27 0.8 9.14 0.45 6.42e-18 Eosinophilic esophagitis; LUSC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg21361702 chr7:150065534 REPIN1 0.52 6.71 0.34 8.47e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs1395 0.961 rs4665963 chr2:27528692 T/C cg23587288 chr2:27483067 SLC30A3 -0.3 -5.64 -0.3 3.57e-8 Blood metabolite levels; LUSC cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg26384229 chr12:38710491 ALG10B 0.92 15.81 0.65 1.92e-42 Bladder cancer; LUSC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg06494592 chr3:125709126 NA -0.5 -6.15 -0.32 2.25e-9 Blood pressure (smoking interaction); LUSC trans rs853679 0.607 rs34218844 chr6:28290647 T/C cg01620082 chr3:125678407 NA -0.82 -7.65 -0.39 2.2e-13 Depression; LUSC cis rs1904096 0.506 rs3113863 chr4:95147827 G/C cg11021082 chr4:95130006 SMARCAD1 -0.45 -8.37 -0.42 1.57e-15 Type 2 diabetes; LUSC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg26513180 chr16:89883248 FANCA 0.8 6.4 0.33 5.22e-10 Skin colour saturation; LUSC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg24881330 chr22:46731750 TRMU 0.79 7.06 0.36 9.45e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs314370 0.621 rs314312 chr7:100422642 G/C cg10426581 chr7:100472382 SRRT 0.53 8.13 0.41 8.25e-15 Resting heart rate; LUSC cis rs7107174 0.792 rs10751287 chr11:78072476 T/C cg02023728 chr11:77925099 USP35 0.47 7.06 0.36 9.75e-12 Testicular germ cell tumor; LUSC cis rs4664308 0.618 rs4665139 chr2:160890692 G/T cg03641300 chr2:160917029 PLA2R1 -0.48 -8.0 -0.4 2.03e-14 Idiopathic membranous nephropathy; LUSC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg23625390 chr15:77176239 SCAPER 0.45 6.9 0.35 2.55e-11 Blood metabolite levels; LUSC trans rs13424581 1.000 rs10193574 chr2:225741272 C/T cg12623045 chr10:135067449 NA -0.49 -6.2 -0.32 1.69e-9 Platelet distribution width; LUSC cis rs6960043 0.714 rs6976086 chr7:15048611 T/G cg19272540 chr7:15055459 NA 0.35 8.6 0.43 3.07e-16 Type 2 diabetes; LUSC cis rs2354432 0.607 rs6683243 chr1:146733422 A/T cg25205988 chr1:146714368 CHD1L -1.0 -9.35 -0.46 1.26e-18 Mitochondrial DNA levels; LUSC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.45 6.27 0.32 1.1e-9 Renal function-related traits (BUN); LUSC cis rs9807989 0.773 rs5010059 chr2:102968826 C/G cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs4892230 1 rs4892230 chr18:72155572 G/A cg25817165 chr18:72167213 CNDP2 -0.56 -7.53 -0.38 4.66e-13 Mononucleosis; LUSC cis rs6500395 1.000 rs3817029 chr16:48584942 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.48 0.33 3.31e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs5167 0.533 rs55778858 chr19:45485465 G/A cg13119609 chr19:45449297 APOC2 0.34 5.67 0.3 3.01e-8 Blood protein levels; LUSC cis rs11122272 0.735 rs2808602 chr1:231537303 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.92 -0.48 1.7e-20 Hemoglobin concentration; LUSC cis rs968451 0.789 rs1569500 chr22:39683515 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.71 10.43 0.5 3.2e-22 Primary biliary cholangitis; LUSC cis rs8028313 0.731 rs11857017 chr15:67972908 A/G cg24579218 chr15:68104479 NA -0.38 -6.55 -0.34 2.21e-10 Obesity; LUSC cis rs9392556 0.829 rs613260 chr6:4120567 C/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.36 -6.16 -0.32 2.06e-9 Blood metabolite levels; LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg01802117 chr1:53393560 SCP2 -0.37 -6.13 -0.32 2.52e-9 Monocyte count; LUSC cis rs34779708 0.733 rs4007271 chr10:35546611 C/T cg03585969 chr10:35415529 CREM 0.53 7.38 0.37 1.3e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg06481639 chr22:41940642 POLR3H -0.46 -5.67 -0.3 3.09e-8 Vitiligo; LUSC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg23985595 chr17:80112537 CCDC57 -0.32 -6.12 -0.32 2.63e-9 Life satisfaction; LUSC cis rs748404 0.697 rs546722 chr15:43580819 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.57 8.86 0.44 5.01e-17 Lung cancer; LUSC trans rs7937682 0.961 rs7119563 chr11:111543916 T/A cg18187862 chr3:45730750 SACM1L -0.53 -6.51 -0.34 2.71e-10 Primary sclerosing cholangitis; LUSC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.97 0.4 2.6e-14 Prudent dietary pattern; LUSC cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg25208724 chr1:156163844 SLC25A44 1.1 27.15 0.83 1.64e-86 Testicular germ cell tumor; LUSC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg22508957 chr16:3507546 NAT15 0.65 10.68 0.5 4.06e-23 Tuberculosis; LUSC cis rs748404 0.578 rs507178 chr15:43610135 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.61 9.46 0.46 5.61e-19 Lung cancer; LUSC cis rs2439831 1.000 rs527921 chr15:43770416 G/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.81 -8.62 -0.43 2.7e-16 Lung cancer in ever smokers; LUSC trans rs7937682 0.889 rs490199 chr11:111487890 A/G cg18187862 chr3:45730750 SACM1L 0.52 6.82 0.35 4.21e-11 Primary sclerosing cholangitis; LUSC cis rs4820539 0.932 rs3788349 chr22:23467950 A/G cg14186256 chr22:23484241 RTDR1 0.96 18.11 0.7 1.53e-51 Bone mineral density; LUSC cis rs7173743 0.756 rs12903613 chr15:79129076 G/T cg00540400 chr15:79124168 NA 0.35 6.15 0.32 2.17e-9 Coronary artery disease; LUSC cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg00409905 chr10:38381863 ZNF37A -0.35 -6.16 -0.32 2.04e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg03354898 chr7:1950403 MAD1L1 -0.33 -6.51 -0.34 2.8e-10 Bipolar disorder and schizophrenia; LUSC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg01579765 chr21:45077557 HSF2BP -0.51 -10.66 -0.5 5.13e-23 Mean corpuscular volume; LUSC cis rs5750830 0.645 rs4821890 chr22:39777523 G/A cg02038168 chr22:39784481 NA -0.48 -8.01 -0.4 1.92e-14 Intelligence (multi-trait analysis); LUSC trans rs7819412 0.936 rs7814499 chr8:11040647 A/G cg15556689 chr8:8085844 FLJ10661 -0.59 -8.87 -0.44 4.49e-17 Triglycerides; LUSC cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg22709100 chr7:91322751 NA -0.42 -6.12 -0.32 2.69e-9 Breast cancer; LUSC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg06108461 chr20:60628389 TAF4 -1.0 -16.81 -0.68 2.25e-46 Body mass index; LUSC cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg05283184 chr6:79620031 NA -0.57 -11.99 -0.55 8.43e-28 Intelligence (multi-trait analysis); LUSC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg08645402 chr16:4508243 NA 0.48 7.52 0.38 5.19e-13 Schizophrenia; LUSC cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs4356932 0.967 rs4859591 chr4:76948578 G/A cg00809888 chr4:76862425 NAAA 0.35 5.79 0.3 1.64e-8 Blood protein levels; LUSC cis rs11249608 0.548 rs7709054 chr5:178462757 C/T cg21905437 chr5:178450457 ZNF879 0.43 5.67 0.3 3.1e-8 Pubertal anthropometrics; LUSC cis rs7568458 0.684 rs1048739 chr2:85764968 T/G cg23752985 chr2:85803571 VAMP8 0.33 6.34 0.33 7.49e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs2346177 0.554 rs36006825 chr2:46708945 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.6 -9.47 -0.46 5.4e-19 HDL cholesterol; LUSC cis rs6977660 0.714 rs6976854 chr7:19818311 A/G cg05791153 chr7:19748676 TWISTNB 0.66 7.0 0.36 1.38e-11 Thyroid stimulating hormone; LUSC cis rs10089 1.000 rs10057122 chr5:127512063 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.83 10.95 0.51 4.75e-24 Ileal carcinoids; LUSC cis rs7267979 0.668 rs4815398 chr20:25237338 C/T cg08601574 chr20:25228251 PYGB -0.46 -6.96 -0.36 1.79e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg04545296 chr12:48745243 ZNF641 0.37 6.72 0.35 7.87e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs679087 0.900 rs12811019 chr12:29935396 C/A cg14258853 chr12:29935411 TMTC1 0.97 16.92 0.68 8.18e-47 Schizophrenia; LUSC cis rs908922 0.676 rs1856120 chr1:152512441 G/A cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.0 -0.58 1.53e-31 Alzheimer's disease; LUSC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.17 0.37 4.75e-12 Blood metabolite levels; LUSC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg06221963 chr1:154839813 KCNN3 -0.59 -13.47 -0.59 2.55e-33 Prostate cancer; LUSC cis rs1595825 0.838 rs16826872 chr2:198898055 T/C cg00982548 chr2:198649783 BOLL -0.55 -7.0 -0.36 1.44e-11 Ulcerative colitis; LUSC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg21644426 chr2:191273491 MFSD6 -0.58 -9.4 -0.46 9.24e-19 Pulse pressure; LUSC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg03709012 chr19:19516395 GATAD2A 0.84 14.22 0.61 3.15e-36 Tonsillectomy; LUSC cis rs10751667 0.666 rs7396473 chr11:966181 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.4 0.33 5.39e-10 Alzheimer's disease (late onset); LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs295140 1.000 rs13028959 chr2:201185919 C/A cg04283868 chr2:201171347 SPATS2L 0.42 6.37 0.33 6.12e-10 QT interval; LUSC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg25767906 chr1:53392781 SCP2 0.53 9.81 0.47 3.97e-20 Monocyte count; LUSC cis rs10208940 0.920 rs10205573 chr2:68829419 A/T cg12452813 chr2:68675892 NA 0.58 6.05 0.31 3.94e-9 Urate levels in lean individuals; LUSC cis rs73110464 0.505 rs2682296 chr12:53308265 G/A cg05393297 chr12:53359155 NA -0.35 -6.46 -0.33 3.75e-10 Cancer (pleiotropy); LUSC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg19592336 chr6:28129416 ZNF389 0.5 6.71 0.34 8.55e-11 Depression; LUSC cis rs9300255 0.620 rs1727311 chr12:123660716 T/G cg13010344 chr12:123464640 ARL6IP4 -0.57 -6.79 -0.35 5.23e-11 Neutrophil percentage of white cells; LUSC cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg01884057 chr2:25150051 NA 0.48 11.49 0.53 5.56e-26 Body mass index; LUSC cis rs7824557 0.628 rs6601580 chr8:11193736 T/G cg21775007 chr8:11205619 TDH 0.8 13.53 0.6 1.47e-33 Retinal vascular caliber; LUSC cis rs1499972 0.941 rs55779525 chr3:117651483 A/C cg07612923 chr3:117604196 NA 0.65 5.85 0.3 1.18e-8 Schizophrenia; LUSC trans rs7819412 0.522 rs3021495 chr8:10994743 C/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.34 -0.33 7.39e-10 Triglycerides; LUSC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg05110241 chr16:68378359 PRMT7 -0.57 -6.52 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs921968 0.643 rs1344645 chr2:219538019 A/C cg02176678 chr2:219576539 TTLL4 0.58 10.59 0.5 8.84e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg18904891 chr8:8559673 CLDN23 0.4 6.36 0.33 6.72e-10 Mood instability; LUSC cis rs8062405 1.000 rs11861174 chr16:28871989 A/G cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg10130564 chr11:117069849 TAGLN -0.37 -6.44 -0.33 4.18e-10 Blood protein levels; LUSC cis rs6121246 0.559 rs10439608 chr20:30258814 T/C cg13852791 chr20:30311386 BCL2L1 0.96 14.98 0.63 3.73e-39 Mean corpuscular hemoglobin; LUSC cis rs9393777 0.623 rs16891717 chr6:26477143 T/A cg09904177 chr6:26538194 HMGN4 -0.51 -5.71 -0.3 2.54e-8 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg12419862 chr22:24373484 LOC391322 -0.81 -12.03 -0.55 5.99e-28 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.63 10.89 0.51 7.85e-24 Menopause (age at onset); LUSC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg02772935 chr3:125709198 NA -0.47 -5.66 -0.3 3.26e-8 Blood pressure (smoking interaction); LUSC cis rs611744 0.647 rs6981420 chr8:109266694 T/G cg18478394 chr8:109455254 TTC35 0.42 6.57 0.34 1.93e-10 Dupuytren's disease; LUSC cis rs11098499 0.687 rs71610270 chr4:120287436 A/G cg24375607 chr4:120327624 NA 0.68 10.09 0.48 4.69e-21 Corneal astigmatism; LUSC trans rs9615838 0.579 rs9615822 chr22:48624381 A/G cg01224366 chr21:45148694 PDXK -0.65 -6.28 -0.32 1.08e-9 Facial morphology (factor 2, vertical position of orbits relative to midface); LUSC cis rs9287719 0.967 rs7582775 chr2:10738449 C/T cg00105475 chr2:10696890 NA 0.37 6.21 0.32 1.58e-9 Prostate cancer; LUSC cis rs7264396 0.635 rs6060673 chr20:34482396 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.59 8.81 0.43 6.87e-17 Total cholesterol levels; LUSC cis rs16910800 1.000 rs1531808 chr11:23194465 C/A cg20040320 chr11:23191996 NA -0.46 -6.62 -0.34 1.42e-10 Cancer; LUSC cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg06552810 chr11:31128660 NA -0.42 -7.4 -0.38 1.09e-12 Red blood cell count; LUSC trans rs2727020 0.595 rs10466496 chr11:49501514 C/T cg03929089 chr4:120376271 NA -0.99 -17.49 -0.69 4.35e-49 Coronary artery disease; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg20887711 chr4:1340912 KIAA1530 0.7 10.84 0.51 1.2e-23 Longevity; LUSC cis rs698813 0.674 rs4952707 chr2:44500683 G/C cg00619915 chr2:44497795 NA -0.53 -7.26 -0.37 2.68e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs9837602 0.872 rs4928234 chr3:99704861 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 5.89 0.31 9.26e-9 Breast cancer; LUSC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg03934478 chr11:495069 RNH1 0.85 9.17 0.45 5.14e-18 Body mass index; LUSC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg13206674 chr6:150067644 NUP43 0.42 6.38 0.33 5.88e-10 Testicular germ cell tumor; LUSC cis rs10875746 0.903 rs11168403 chr12:48484958 T/C cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC trans rs2243480 1.000 rs35735127 chr7:65300423 G/T cg10756647 chr7:56101905 PSPH 0.87 8.4 0.42 1.31e-15 Diabetic kidney disease; LUSC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg18477163 chr1:228402036 OBSCN -0.56 -10.21 -0.49 1.83e-21 Diastolic blood pressure; LUSC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg12257692 chr3:49977190 RBM6 0.24 6.74 0.35 6.86e-11 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.818 rs398812 chr6:145817271 T/C cg23711669 chr6:146136114 FBXO30 0.74 13.21 0.59 2.48e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs2797160 0.967 rs1739358 chr6:126019736 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.94 0.36 2.04e-11 Endometrial cancer; LUSC cis rs7589342 0.831 rs6731173 chr2:106522928 A/G cg14210321 chr2:106509881 NCK2 -0.61 -9.51 -0.46 3.82e-19 Addiction; LUSC cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg24642439 chr20:33292090 TP53INP2 0.51 7.65 0.39 2.14e-13 Height; LUSC cis rs243505 0.528 rs740951 chr7:148470160 C/A cg09806900 chr7:148480153 CUL1 0.65 9.72 0.47 8.01e-20 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg22782873 chr19:19639568 YJEFN3 -0.49 -6.12 -0.32 2.56e-9 Bipolar disorder; LUSC trans rs7824557 0.767 rs7837036 chr8:11175489 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.89 0.35 2.86e-11 Retinal vascular caliber; LUSC cis rs1153858 1.000 rs1288775 chr15:45661678 T/A cg21132104 chr15:45694354 SPATA5L1 0.59 8.31 0.41 2.49e-15 Homoarginine levels; LUSC cis rs6087771 0.662 rs6058298 chr20:30247916 C/T cg13852791 chr20:30311386 BCL2L1 0.89 12.8 0.57 8.82e-31 Subcortical brain region volumes;Putamen volume; LUSC cis rs1034435 0.755 rs9615336 chr22:48893090 G/C cg05992904 chr22:48892994 FAM19A5 -0.41 -8.16 -0.41 6.85e-15 Late-onset Alzheimer's disease; LUSC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg14784868 chr12:69753453 YEATS4 0.61 8.85 0.44 5.33e-17 Blood protein levels; LUSC cis rs72634258 0.554 rs4908704 chr1:7918904 A/G cg26816564 chr1:7831052 VAMP3 0.72 9.63 0.47 1.53e-19 Inflammatory bowel disease; LUSC trans rs2587949 0.615 rs1385486 chr3:4228745 C/T cg15139668 chr4:4577005 NA -0.41 -6.08 -0.32 3.23e-9 Periodontitis (DPAL); LUSC cis rs2204008 0.687 rs11181339 chr12:38322271 G/T cg26384229 chr12:38710491 ALG10B 0.81 13.65 0.6 4.94e-34 Bladder cancer; LUSC cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg26384229 chr12:38710491 ALG10B 0.93 15.68 0.65 6.74e-42 Bladder cancer; LUSC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.49 0.38 6.06e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg11344533 chr11:111475393 SIK2 -0.46 -6.31 -0.33 8.96e-10 Primary sclerosing cholangitis; LUSC cis rs56804039 1.000 rs58361948 chr8:8380995 C/T cg15556689 chr8:8085844 FLJ10661 -0.56 -6.96 -0.36 1.84e-11 Cervical cancer; LUSC cis rs11190604 1.000 rs10883512 chr10:102308516 A/G cg07080220 chr10:102295463 HIF1AN 0.69 9.22 0.45 3.32e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs11031096 0.738 rs11031070 chr11:4154307 T/C cg18678763 chr11:4115507 RRM1 0.38 5.77 0.3 1.83e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs11864453 0.826 rs2072142 chr16:72132713 C/T cg23815491 chr16:72088622 HP 0.34 5.97 0.31 6.12e-9 Fibrinogen levels; LUSC cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.0 -0.48 8.83e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg22857025 chr5:266934 NA -1.14 -16.68 -0.67 7.08e-46 Breast cancer; LUSC cis rs7771547 0.642 rs12214285 chr6:36434679 C/T cg07856975 chr6:36356162 ETV7 -0.37 -6.47 -0.33 3.41e-10 Platelet distribution width; LUSC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -6.41 -0.33 5.01e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.14 -0.32 2.38e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.52 -7.64 -0.39 2.35e-13 Axial length; LUSC cis rs10744422 0.858 rs7980541 chr12:123379477 C/T cg25930673 chr12:123319894 HIP1R -0.66 -6.52 -0.34 2.53e-10 Schizophrenia; LUSC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg12379764 chr21:47803548 PCNT 0.59 8.15 0.41 7.38e-15 Testicular germ cell tumor; LUSC cis rs1322512 0.917 rs2489545 chr6:153006907 C/T cg27316956 chr6:152958899 SYNE1 0.34 5.98 0.31 5.72e-9 Tonometry; LUSC cis rs17270561 0.609 rs9379785 chr6:25726213 G/A cg17691542 chr6:26056736 HIST1H1C 0.58 8.03 0.4 1.68e-14 Iron status biomarkers; LUSC cis rs9399401 0.614 rs262125 chr6:142838355 A/T cg03128060 chr6:142623767 GPR126 0.52 8.39 0.42 1.38e-15 Chronic obstructive pulmonary disease; LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg01238044 chr22:24384105 GSTT1 -0.52 -7.59 -0.38 3.15e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg07395648 chr5:131743802 NA -0.43 -7.29 -0.37 2.28e-12 Blood metabolite levels; LUSC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg02807482 chr3:125708958 NA -0.52 -6.51 -0.34 2.69e-10 Blood pressure (smoking interaction); LUSC cis rs11098499 0.754 rs10213554 chr4:120260785 A/G cg09307838 chr4:120376055 NA -0.67 -9.98 -0.48 1.06e-20 Corneal astigmatism; LUSC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.47 9.3 0.45 1.84e-18 Monocyte percentage of white cells; LUSC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 14.88 0.63 8.88e-39 Platelet count; LUSC cis rs11785400 0.793 rs4567014 chr8:143737690 G/C cg10596483 chr8:143751796 JRK 0.52 7.61 0.38 2.9e-13 Schizophrenia; LUSC trans rs6981523 0.553 rs11783045 chr8:11056175 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.41 -0.38 1.04e-12 Neuroticism; LUSC trans rs11098499 0.909 rs6842762 chr4:120398236 A/T cg25214090 chr10:38739885 LOC399744 0.56 8.33 0.41 2.16e-15 Corneal astigmatism; LUSC cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg13010199 chr12:38710504 ALG10B 0.65 10.2 0.49 1.93e-21 Morning vs. evening chronotype; LUSC cis rs4474465 1.000 rs10899502 chr11:78141021 C/T cg27205649 chr11:78285834 NARS2 -0.55 -6.33 -0.33 7.7e-10 Alzheimer's disease (survival time); LUSC cis rs2267137 0.843 rs570731 chr22:29758817 A/G cg07256473 chr22:29710276 RASL10A -0.38 -7.33 -0.37 1.77e-12 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs791888 0.728 rs2255682 chr10:89419873 C/G cg13926569 chr10:89418898 PAPSS2 -0.36 -6.89 -0.35 2.75e-11 Magnesium levels; LUSC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg25124228 chr12:125621409 AACS -0.45 -6.81 -0.35 4.44e-11 Post bronchodilator FEV1/FVC ratio; LUSC cis rs9790314 0.846 rs7627528 chr3:160990878 A/G cg03342759 chr3:160939853 NMD3 -0.57 -9.69 -0.47 9.72e-20 Morning vs. evening chronotype; LUSC cis rs10276381 1.000 rs10276381 chr7:28190121 A/G cg23620719 chr7:28220237 JAZF1 -0.6 -6.75 -0.35 6.72e-11 Crohn's disease; LUSC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg21518248 chr2:162101506 NA 0.45 6.87 0.35 3.14e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; LUSC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg09417038 chr21:47716443 C21orf57 -0.43 -6.73 -0.35 7.5e-11 Testicular germ cell tumor; LUSC cis rs4964805 0.865 rs67825151 chr12:104205444 C/T cg02344784 chr12:104178138 NT5DC3 0.4 6.37 0.33 6.4e-10 Attention deficit hyperactivity disorder; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg11060661 chr22:24314208 DDT;DDTL 0.49 7.97 0.4 2.59e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs11758351 0.866 rs55815656 chr6:26207303 G/A cg23601095 chr6:26197514 HIST1H3D 0.68 7.51 0.38 5.59e-13 Gout;Renal underexcretion gout; LUSC cis rs7267979 1.000 rs2258066 chr20:25271326 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.44 0.75 8.43e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg11344533 chr11:111475393 SIK2 -0.49 -6.69 -0.34 9.69e-11 Primary sclerosing cholangitis; LUSC cis rs11992162 0.967 rs4840601 chr8:11828730 G/C cg21775007 chr8:11205619 TDH 0.51 7.31 0.37 2.04e-12 Monocyte count; LUSC cis rs1949733 1.000 rs2688233 chr4:8491885 T/C cg13073564 chr4:8508604 NA -0.46 -8.74 -0.43 1.17e-16 Response to antineoplastic agents; LUSC cis rs10876993 0.890 rs12302351 chr12:58062590 T/C cg18357645 chr12:58087776 OS9 0.54 8.11 0.41 9.5e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg18904891 chr8:8559673 CLDN23 0.56 7.71 0.39 1.43e-13 Obesity-related traits; LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg10802521 chr3:52805072 NEK4 -0.55 -8.52 -0.42 5.6e-16 Bipolar disorder; LUSC cis rs2439831 1.000 rs101094 chr15:43787322 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.86 8.94 0.44 2.78e-17 Lung cancer in ever smokers; LUSC cis rs9326248 0.861 rs11216172 chr11:116749878 G/A cg10130564 chr11:117069849 TAGLN 0.34 5.69 0.3 2.82e-8 Blood protein levels; LUSC cis rs12618769 0.597 rs3769724 chr2:99105981 C/T cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg00484396 chr16:3507460 NAT15 0.71 12.23 0.56 1.09e-28 Tuberculosis; LUSC cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg26384229 chr12:38710491 ALG10B 0.88 14.9 0.63 7.45e-39 Drug-induced liver injury (flucloxacillin); LUSC cis rs7605378 1.000 rs7577763 chr2:200681753 C/T cg23649088 chr2:200775458 C2orf69 0.49 7.44 0.38 8.65e-13 Osteoporosis; LUSC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg13319975 chr6:146136371 FBXO30 -0.51 -7.74 -0.39 1.17e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs17270561 0.666 rs17320090 chr6:25720215 C/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.9 0.44 3.71e-17 Iron status biomarkers; LUSC cis rs6964587 0.967 rs12538325 chr7:91757479 A/G cg17063962 chr7:91808500 NA 0.57 8.79 0.43 8.3e-17 Breast cancer; LUSC cis rs9398803 0.830 rs1337735 chr6:126771024 T/A cg19875578 chr6:126661172 C6orf173 0.42 6.18 0.32 1.9e-9 Male-pattern baldness; LUSC cis rs8060686 0.546 rs7188350 chr16:68149316 T/C cg09835421 chr16:68378352 PRMT7 -0.44 -5.78 -0.3 1.69e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs1865760 0.516 rs9358903 chr6:26061949 A/C cg16482183 chr6:26056742 HIST1H1C 0.56 8.43 0.42 1.01e-15 Height; LUSC cis rs2404618 0.593 rs7815979 chr8:1484887 A/G cg13402656 chr8:1511478 DLGAP2 -0.61 -10.38 -0.49 4.47e-22 Lung cancer; LUSC cis rs68170813 0.559 rs74387778 chr7:106963213 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.46 -0.46 5.6e-19 Coronary artery disease; LUSC cis rs826838 1.000 rs826889 chr12:39101076 G/A cg26384229 chr12:38710491 ALG10B -0.84 -15.98 -0.66 4.2e-43 Heart rate; LUSC cis rs1153858 0.621 rs2687512 chr15:45581495 T/C cg21132104 chr15:45694354 SPATA5L1 -0.5 -6.63 -0.34 1.37e-10 Homoarginine levels; LUSC cis rs10782582 0.609 rs112431348 chr1:76275571 A/G cg03433033 chr1:76189801 ACADM -0.42 -6.21 -0.32 1.57e-9 Daytime sleep phenotypes; LUSC cis rs789859 0.965 rs789858 chr3:194405966 C/T cg02072170 chr3:194406190 FAM43A 0.36 7.57 0.38 3.65e-13 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.65 -0.43 2.26e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs892961 0.932 rs7223768 chr17:75410521 G/A cg05865280 chr17:75406074 SEPT9 0.47 10.22 0.49 1.65e-21 Airflow obstruction; LUSC cis rs6433857 0.505 rs1542036 chr2:181350009 A/C cg23363182 chr2:181467187 NA -0.45 -7.26 -0.37 2.76e-12 Body mass index; LUSC cis rs2219968 0.962 rs10808824 chr8:78926741 G/A cg00738934 chr8:78996279 NA 0.39 7.06 0.36 9.45e-12 Prostate cancer (SNP x SNP interaction); LUSC trans rs4714291 0.832 rs7764688 chr6:40115442 G/T cg02267698 chr19:7991119 CTXN1 -0.54 -8.08 -0.4 1.18e-14 Strep throat; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.43 0.42 1.06e-15 Prudent dietary pattern; LUSC cis rs1448094 0.967 rs10047659 chr12:86338278 C/A cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.56e-9 Major depressive disorder; LUSC trans rs1728785 1.000 rs698719 chr16:68560125 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.57 0.38 3.58e-13 Ulcerative colitis; LUSC cis rs11677416 1.000 rs61381693 chr2:113525912 C/A cg27083787 chr2:113543245 IL1A 0.46 7.05 0.36 1.05e-11 Response to antipsychotic treatment in schizophrenia (working memory); LUSC trans rs35110281 0.807 rs9976441 chr21:45046591 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.59 10.18 0.49 2.17e-21 Mean corpuscular volume; LUSC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg15383120 chr6:291909 DUSP22 -0.47 -7.18 -0.37 4.56e-12 Menopause (age at onset); LUSC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg02423579 chr7:2872169 GNA12 -0.41 -5.95 -0.31 6.71e-9 Height; LUSC cis rs9987353 0.589 rs1053036 chr8:9060077 A/G cg06636001 chr8:8085503 FLJ10661 -0.41 -5.97 -0.31 6.04e-9 Recombination measurement; LUSC cis rs748404 0.660 rs518288 chr15:43763999 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs977987 0.750 rs4888414 chr16:75447233 A/G cg03315344 chr16:75512273 CHST6 0.48 8.92 0.44 3.16e-17 Dupuytren's disease; LUSC cis rs79387448 0.655 rs17639215 chr2:102953444 G/A cg09003973 chr2:102972529 NA 1.18 12.45 0.56 1.76e-29 Gut microbiota (bacterial taxa); LUSC cis rs7216064 1.000 rs62084251 chr17:65878736 G/A cg12091567 chr17:66097778 LOC651250 -0.74 -9.3 -0.45 1.92e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs5758511 0.680 rs739146 chr22:42660414 A/G cg00645731 chr22:42541494 CYP2D7P1 0.56 9.92 0.48 1.71e-20 Birth weight; LUSC cis rs921968 0.612 rs4674323 chr2:219517088 T/C cg02176678 chr2:219576539 TTLL4 0.59 10.64 0.5 6.05e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs262150 0.501 rs2730206 chr7:158815173 G/C cg19418458 chr7:158789849 NA -0.63 -10.4 -0.49 4.1e-22 Facial morphology (factor 20); LUSC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg22868518 chr11:507468 RNH1 -0.58 -5.76 -0.3 1.95e-8 Body mass index; LUSC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg13902645 chr11:5959945 NA -0.55 -7.7 -0.39 1.54e-13 DNA methylation (variation); LUSC cis rs9677476 0.863 rs10202295 chr2:232084411 T/G cg07929768 chr2:232055508 NA 0.36 6.76 0.35 6.31e-11 Food antigen IgG levels; LUSC cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.19 0.37 4.36e-12 Cognitive ability; LUSC cis rs7804356 0.954 rs3823929 chr7:26856600 T/C cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.08e-9 Type 1 diabetes; LUSC cis rs826838 0.616 rs7966266 chr12:38626138 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.75 -0.35 6.46e-11 Heart rate; LUSC cis rs763121 0.889 rs9610971 chr22:38910810 C/T cg06022373 chr22:39101656 GTPBP1 0.77 11.65 0.54 1.5e-26 Menopause (age at onset); LUSC cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC cis rs870825 0.616 rs7683615 chr4:185618373 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg16240275 chr20:61666158 NCRNA00029 0.42 9.24 0.45 2.9e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg13902645 chr11:5959945 NA -0.58 -8.03 -0.4 1.64e-14 DNA methylation (variation); LUSC cis rs2204008 0.776 rs8186824 chr12:38316537 A/C cg13010199 chr12:38710504 ALG10B 0.64 9.79 0.47 4.52e-20 Bladder cancer; LUSC cis rs7582180 0.629 rs74177696 chr2:100938481 C/G cg08017756 chr2:100939284 LONRF2 -0.46 -8.58 -0.42 3.67e-16 Intelligence (multi-trait analysis); LUSC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg00701064 chr4:6280414 WFS1 0.58 13.86 0.6 7.78e-35 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13341460 chr6:126307568 TRMT11 0.69 6.33 0.33 7.73e-10 Cognitive performance; LUSC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg08736216 chr1:53307985 ZYG11A 0.3 6.19 0.32 1.78e-9 Monocyte count; LUSC cis rs1843834 0.898 rs2015099 chr2:225519915 T/C cg22455342 chr2:225449267 CUL3 0.44 6.02 0.31 4.54e-9 IgE levels in asthmatics (D.p. specific); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02871028 chr19:32896878 DPY19L3 -0.43 -6.61 -0.34 1.54e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2688608 1.000 rs2675680 chr10:75658864 T/C cg17411546 chr10:75410026 SYNPO2L -0.45 -6.79 -0.35 5.01e-11 Inflammatory bowel disease; LUSC cis rs8017423 0.967 rs11628881 chr14:90713833 C/T cg14092571 chr14:90743983 NA -0.35 -5.75 -0.3 2.03e-8 Mortality in heart failure; LUSC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg16339924 chr4:17578868 LAP3 0.63 9.88 0.48 2.3e-20 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg11645453 chr3:52864694 ITIH4 0.34 8.0 0.4 2.03e-14 Bipolar disorder; LUSC cis rs11971779 0.680 rs6978680 chr7:139112048 A/G cg23387468 chr7:139079360 LUC7L2 -0.41 -6.25 -0.32 1.25e-9 Diisocyanate-induced asthma; LUSC cis rs2204008 0.720 rs11170774 chr12:38021722 C/T cg26384229 chr12:38710491 ALG10B -0.81 -13.45 -0.59 3.08e-33 Bladder cancer; LUSC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg09455208 chr3:40491958 NA 0.59 10.22 0.49 1.57e-21 Renal cell carcinoma; LUSC cis rs11758351 0.866 rs75091077 chr6:26207546 A/C cg23601095 chr6:26197514 HIST1H3D 0.66 7.37 0.37 1.39e-12 Gout;Renal underexcretion gout; LUSC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg24110177 chr3:50126178 RBM5 0.65 11.46 0.53 7.18e-26 Body mass index; LUSC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg06028605 chr16:24865363 SLC5A11 -0.7 -11.23 -0.52 4.7e-25 Intelligence (multi-trait analysis); LUSC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg13770153 chr20:60521292 NA -0.62 -8.32 -0.41 2.23e-15 Body mass index; LUSC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg26513180 chr16:89883248 FANCA 0.79 6.38 0.33 5.97e-10 Skin colour saturation; LUSC cis rs6424115 0.790 rs72874118 chr1:24177800 A/G cg15997130 chr1:24165203 NA -0.52 -8.24 -0.41 3.91e-15 Immature fraction of reticulocytes; LUSC cis rs4478037 1.000 rs56733391 chr3:33161434 G/A cg19404215 chr3:33155277 CRTAP 0.96 9.76 0.47 5.72e-20 Major depressive disorder; LUSC cis rs977987 0.843 rs4887820 chr16:75397287 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.91 -0.35 2.52e-11 Dupuytren's disease; LUSC cis rs28647808 0.786 rs4962134 chr9:136256626 G/A cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg11494091 chr17:61959527 GH2 0.63 13.47 0.59 2.59e-33 Prudent dietary pattern; LUSC cis rs17818399 0.888 rs2346419 chr2:46845069 G/C cg02822958 chr2:46747628 ATP6V1E2 0.39 6.27 0.32 1.13e-9 Height; LUSC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg02275930 chr1:2372054 NA -0.54 -9.25 -0.45 2.77e-18 Schizophrenia; LUSC cis rs477895 1.000 rs66968227 chr11:64070930 T/C cg04317338 chr11:64019027 PLCB3 0.57 5.81 0.3 1.48e-8 Mean platelet volume; LUSC cis rs59698941 0.943 rs12519955 chr5:132283095 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs2652834 0.718 rs8034945 chr15:63397207 G/A cg05507819 chr15:63340323 TPM1 0.55 7.07 0.36 8.99e-12 HDL cholesterol; LUSC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg12386194 chr3:101231763 SENP7 0.48 6.97 0.36 1.67e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg00530320 chr1:46809349 NSUN4 0.56 8.71 0.43 1.42e-16 Menopause (age at onset); LUSC cis rs524023 1.000 rs559946 chr11:64358605 T/C cg07220939 chr11:64358617 SLC22A12 0.23 5.99 0.31 5.48e-9 Urate levels in obese individuals; LUSC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.54 0.34 2.35e-10 Lung cancer; LUSC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg00409905 chr10:38381863 ZNF37A -0.38 -6.38 -0.33 5.86e-10 Extrinsic epigenetic age acceleration; LUSC cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg27446573 chr6:127587934 RNF146 0.9 14.73 0.63 3.34e-38 Breast cancer; LUSC trans rs10949834 0.824 rs3801461 chr7:73536368 C/G cg08527172 chr7:62560487 NA 0.41 6.03 0.31 4.32e-9 Verbal memory performance (residualized delayed recall change); LUSC trans rs7819412 0.525 rs10086521 chr8:10783769 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.36 -0.33 6.6e-10 Triglycerides; LUSC cis rs2370759 0.898 rs113412621 chr10:32579306 C/T cg01819863 chr10:32635814 EPC1 1.08 13.44 0.59 3.21e-33 Sexual dysfunction (female); LUSC cis rs9399135 0.967 rs4142299 chr6:135377186 G/T cg24558204 chr6:135376177 HBS1L 0.59 9.07 0.44 1.05e-17 Red blood cell count; LUSC trans rs1962073 0.623 rs7459532 chr8:10261068 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.31 -0.33 8.69e-10 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); LUSC trans rs62238980 0.614 rs79738052 chr22:32455812 G/A cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs4722166 0.630 rs6461667 chr7:22796743 A/G cg26061582 chr7:22766209 IL6 0.51 7.39 0.37 1.17e-12 Lung cancer; LUSC cis rs360798 0.512 rs1420018 chr2:63112500 A/G cg17519650 chr2:63277830 OTX1 0.5 6.89 0.35 2.8e-11 Coronary artery disease; LUSC cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.04 0.55 5.81e-28 Hip circumference adjusted for BMI; LUSC cis rs782590 0.934 rs17369191 chr2:55757885 T/C cg18811423 chr2:55921094 PNPT1 0.82 14.51 0.62 2.39e-37 Metabolic syndrome; LUSC cis rs6138458 1.000 rs6106984 chr20:24977006 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -7.67 -0.39 1.89e-13 Blood protein levels; LUSC cis rs7666738 0.546 rs34159897 chr4:98787367 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.63 0.43 2.47e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg27121462 chr16:89883253 FANCA 0.54 8.4 0.42 1.32e-15 Vitiligo; LUSC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg20406979 chr6:167373233 NA 0.26 6.29 0.33 9.8e-10 Crohn's disease; LUSC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg08270630 chr22:50330655 NA -0.44 -6.61 -0.34 1.48e-10 Schizophrenia; LUSC cis rs9300255 0.602 rs1727306 chr12:123665695 A/G cg13010344 chr12:123464640 ARL6IP4 -0.48 -6.48 -0.33 3.22e-10 Neutrophil percentage of white cells; LUSC cis rs1801251 1.000 rs1867778 chr2:233679644 C/T cg08000102 chr2:233561755 GIGYF2 -0.72 -11.98 -0.55 9.47e-28 Coronary artery disease; LUSC cis rs1577917 0.654 rs9450284 chr6:86199329 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.48 7.63 0.39 2.45e-13 Response to antipsychotic treatment; LUSC cis rs7937682 0.632 rs4935811 chr11:111679262 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.48 0.56 1.29e-29 Primary sclerosing cholangitis; LUSC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2124969 0.506 rs62175396 chr2:161043603 G/A cg03641300 chr2:160917029 PLA2R1 -0.46 -5.69 -0.3 2.72e-8 Waist circumference adjusted for body mass index; LUSC cis rs887829 0.569 rs3806596 chr2:234637707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.43 6.59 0.34 1.76e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs16867321 0.694 rs721301 chr2:181387265 A/G cg23363182 chr2:181467187 NA 0.54 8.43 0.42 1.04e-15 Obesity; LUSC cis rs9611519 0.780 rs5751072 chr22:41656509 C/T cg03806693 chr22:41940476 POLR3H -0.59 -8.74 -0.43 1.19e-16 Neuroticism; LUSC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.05e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs1775715 0.870 rs3847415 chr10:32219456 G/T cg26784012 chr10:32216390 ARHGAP12 0.41 6.9 0.35 2.65e-11 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs569214 1.000 rs569214 chr8:27487790 G/T cg00839333 chr8:27504520 SCARA3 -0.37 -5.75 -0.3 1.99e-8 Alzheimer's disease; LUSC cis rs6840360 0.550 rs7675818 chr4:152690777 C/G cg22705602 chr4:152727874 NA -0.39 -8.61 -0.43 3.03e-16 Intelligence (multi-trait analysis); LUSC cis rs7851660 0.839 rs2417575 chr9:100628642 G/A cg13688889 chr9:100608707 NA -0.56 -8.94 -0.44 2.73e-17 Strep throat; LUSC cis rs911119 0.954 rs2254635 chr20:23622758 G/T cg16589663 chr20:23618590 CST3 0.62 7.83 0.39 6.44e-14 Chronic kidney disease; LUSC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg25554036 chr4:6271136 WFS1 0.61 12.65 0.57 3.12e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg09021430 chr5:549028 NA -0.53 -7.49 -0.38 6.08e-13 Lung disease severity in cystic fibrosis; LUSC cis rs17807624 0.702 rs7815172 chr8:11453671 T/C cg21175976 chr8:11421337 BLK 0.36 6.01 0.31 4.92e-9 Systemic lupus erythematosus; LUSC trans rs9650657 0.547 rs11250099 chr8:10818657 C/T cg06636001 chr8:8085503 FLJ10661 0.54 8.17 0.41 6.51e-15 Neuroticism; LUSC cis rs4853012 0.941 rs7571083 chr2:74342260 C/G cg05776053 chr2:74358815 NA 0.41 6.27 0.32 1.14e-9 Gestational age at birth (maternal effect); LUSC cis rs11229555 0.645 rs12803648 chr11:58177561 G/T cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7683537 0.692 rs56368159 chr4:185654827 T/G cg04058563 chr4:185651563 MLF1IP 0.78 10.48 0.5 2.13e-22 Systemic lupus erythematosus; LUSC cis rs561341 0.709 rs8068049 chr17:30183857 T/C cg00745463 chr17:30367425 LRRC37B 0.89 9.03 0.44 1.45e-17 Hip circumference adjusted for BMI; LUSC trans rs9944715 0.954 rs9960378 chr18:43811262 G/A cg01718231 chr17:29326311 RNF135 -0.54 -7.71 -0.39 1.45e-13 Red cell distribution width;Mean corpuscular volume; LUSC trans rs877282 0.891 rs11599917 chr10:762288 G/A cg22713356 chr15:30763199 NA 1.01 14.09 0.61 1.09e-35 Uric acid levels; LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.17 -0.32 2.02e-9 Platelet count; LUSC cis rs7072216 0.763 rs7910014 chr10:100172110 C/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs6951245 1.000 rs11764748 chr7:1094508 T/C cg08132940 chr7:1081526 C7orf50 -0.52 -6.17 -0.32 1.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7584330 0.638 rs13429533 chr2:238448712 A/G cg16989719 chr2:238392110 NA -0.33 -5.93 -0.31 7.74e-9 Prostate cancer; LUSC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg06627628 chr2:24431161 ITSN2 -0.6 -7.25 -0.37 2.88e-12 Lymphocyte counts; LUSC cis rs8016982 0.632 rs4899786 chr14:81643800 G/T cg01989461 chr14:81687754 GTF2A1 -0.56 -7.16 -0.36 5.13e-12 Schizophrenia; LUSC cis rs1670533 1.000 rs10026482 chr4:1051128 C/G cg27284194 chr4:1044797 NA 0.57 8.42 0.42 1.12e-15 Recombination rate (females); LUSC cis rs10791097 0.678 rs10894272 chr11:130731081 A/G cg12179176 chr11:130786555 SNX19 0.74 12.19 0.55 1.56e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs11622475 1.000 rs11622475 chr14:104509076 C/T cg12183467 chr14:104352244 NA -0.4 -7.81 -0.39 7.35e-14 Bipolar disorder; LUSC cis rs11605924 0.792 rs10838524 chr11:45870177 A/G ch.11.939596F chr11:45881766 CRY2 -0.56 -8.3 -0.41 2.69e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs76419734 0.510 rs2553446 chr4:106696476 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.57 -6.64 -0.34 1.3e-10 Post bronchodilator FEV1; LUSC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg20476274 chr7:133979776 SLC35B4 0.81 14.21 0.61 3.62e-36 Mean platelet volume; LUSC cis rs9300255 0.537 rs1716182 chr12:123686127 A/C cg05973401 chr12:123451056 ABCB9 0.52 6.58 0.34 1.85e-10 Neutrophil percentage of white cells; LUSC cis rs73206853 0.620 rs73194023 chr12:111137940 G/A cg12870014 chr12:110450643 ANKRD13A 0.77 6.83 0.35 4e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs12594515 1.000 rs6493172 chr15:45987213 T/G cg06207120 chr15:45996521 NA 0.4 6.24 0.32 1.31e-9 Waist circumference;Weight; LUSC cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs7833790 0.553 rs9693128 chr8:82706128 A/G cg17211192 chr8:82754475 SNX16 -0.59 -8.75 -0.43 1.07e-16 Diastolic blood pressure; LUSC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg26566898 chr11:117069891 TAGLN 0.48 8.4 0.42 1.33e-15 Blood protein levels; LUSC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg06221963 chr1:154839813 KCNN3 -0.6 -13.68 -0.6 3.97e-34 Prostate cancer; LUSC cis rs7481584 0.624 rs375579 chr11:3065300 G/C cg25174290 chr11:3078921 CARS -0.4 -5.99 -0.31 5.54e-9 Calcium levels; LUSC cis rs12545109 0.800 rs1968551 chr8:57407760 T/C cg09654669 chr8:57350985 NA -0.52 -6.61 -0.34 1.5e-10 Obesity-related traits; LUSC cis rs7212938 0.509 rs62068170 chr17:38103210 G/A cg24910161 chr17:38119198 GSDMA -0.29 -6.46 -0.33 3.76e-10 Asthma and hay fever; LUSC cis rs9420 0.890 rs547891 chr11:57499065 C/T cg23127183 chr11:57508653 C11orf31 0.53 8.17 0.41 6.49e-15 Schizophrenia; LUSC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.6 -0.43 3.08e-16 Personality dimensions; LUSC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg11764359 chr7:65958608 NA -0.68 -10.41 -0.49 3.76e-22 Aortic root size; LUSC trans rs747782 0.528 rs11039674 chr11:48336116 C/T cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.34 9.17e-11 Intraocular pressure; LUSC cis rs559928 1.000 rs641168 chr11:64146289 C/G cg24687543 chr11:63912206 MACROD1 -0.41 -5.76 -0.3 1.94e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs4595586 0.525 rs12818844 chr12:39423806 A/G cg26384229 chr12:38710491 ALG10B 0.52 7.33 0.37 1.73e-12 Morning vs. evening chronotype; LUSC trans rs7980799 0.649 rs1601003 chr12:33689436 A/T cg13010199 chr12:38710504 ALG10B 0.43 6.16 0.32 2.13e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs198426 0.506 rs11230766 chr11:61426582 A/T cg19838087 chr11:61442541 NA -0.31 -6.35 -0.33 7.23e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid); LUSC cis rs9326248 0.769 rs499910 chr11:116763034 G/A cg26566898 chr11:117069891 TAGLN 0.41 6.95 0.36 1.98e-11 Blood protein levels; LUSC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg21644426 chr2:191273491 MFSD6 -0.6 -9.53 -0.46 3.44e-19 Pulse pressure; LUSC cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.26 0.52 3.71e-25 Colorectal cancer; LUSC cis rs10464366 0.798 rs6945380 chr7:39115215 C/T cg18850127 chr7:39170497 POU6F2 0.4 6.0 0.31 5.05e-9 IgG glycosylation; LUSC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.01 0.31 4.76e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6500395 1.000 rs1558815 chr16:48704869 C/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.87 -0.35 3.13e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.65 9.88 0.48 2.39e-20 Lymphocyte counts; LUSC cis rs6084875 0.812 rs2422938 chr20:4721926 G/C cg07258627 chr20:4721683 PRNT -0.34 -6.14 -0.32 2.34e-9 Systemic lupus erythematosus; LUSC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 13.61 0.6 7.33e-34 Smoking behavior; LUSC cis rs3540 0.618 rs11636089 chr15:91039527 C/T cg10434728 chr15:90938212 IQGAP1 0.45 9.09 0.45 9.03e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6700896 0.931 rs79050868 chr1:66120916 G/A cg04111102 chr1:66153794 NA 0.33 7.34 0.37 1.65e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg26446133 chr18:72167187 CNDP2 -0.81 -12.65 -0.57 3.22e-30 Refractive error; LUSC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.28 -0.33 1.04e-9 Total body bone mineral density; LUSC cis rs3105593 0.933 rs11633404 chr15:50899309 C/A cg08437265 chr15:50716283 USP8 0.4 5.95 0.31 6.6e-9 QT interval; LUSC cis rs11690935 0.959 rs10166005 chr2:172607294 C/T cg13550731 chr2:172543902 DYNC1I2 -0.87 -14.19 -0.61 4.1e-36 Schizophrenia; LUSC cis rs17270561 0.609 rs1892246 chr6:25764408 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 7.64 0.39 2.28e-13 Iron status biomarkers; LUSC cis rs9443645 0.527 rs9718121 chr6:79729887 T/A cg05283184 chr6:79620031 NA -0.36 -6.87 -0.35 3.1e-11 Intelligence (multi-trait analysis); LUSC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg18681998 chr4:17616180 MED28 0.91 17.86 0.7 1.55e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg11244672 chr19:19639970 YJEFN3 -0.58 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC cis rs2019216 0.500 rs7359613 chr17:21944028 T/C cg22648282 chr17:21454238 C17orf51 -0.5 -6.83 -0.35 4.12e-11 Pelvic organ prolapse; LUSC cis rs864537 0.676 rs3108155 chr1:167422057 C/G cg22356347 chr1:167427500 CD247 -0.29 -6.61 -0.34 1.54e-10 Celiac disease or Rheumatoid arthritis;Celiac disease; LUSC cis rs9443645 0.509 rs12176511 chr6:79565721 G/A cg09184832 chr6:79620586 NA 0.42 6.62 0.34 1.42e-10 Intelligence (multi-trait analysis); LUSC cis rs9311676 0.632 rs56281646 chr3:58424917 G/A cg26110898 chr3:58419937 PDHB 0.39 6.33 0.33 7.88e-10 Systemic lupus erythematosus; LUSC cis rs9359856 0.600 rs11961825 chr6:90482250 T/A cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.51 -0.42 5.78e-16 Bipolar disorder; LUSC cis rs698833 0.501 rs10194161 chr2:44507213 A/G cg04920474 chr2:44395004 PPM1B -0.55 -9.28 -0.45 2.24e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg12564285 chr5:131593104 PDLIM4 0.33 6.0 0.31 5.21e-9 Blood metabolite levels; LUSC cis rs1801251 1.000 rs13004406 chr2:233584557 A/T cg08000102 chr2:233561755 GIGYF2 -0.68 -11.39 -0.53 1.32e-25 Coronary artery disease; LUSC cis rs7909074 1.000 rs10751360 chr10:45396971 G/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.79 -0.43 7.83e-17 Mean corpuscular volume; LUSC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg00033643 chr7:134001901 SLC35B4 0.45 6.91 0.35 2.46e-11 Mean platelet volume; LUSC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg10802521 chr3:52805072 NEK4 -0.55 -8.91 -0.44 3.39e-17 Electroencephalogram traits; LUSC cis rs201673768 1 rs201673768 chr12:48699606 TGTTTTGTTTTG/T cg21466736 chr12:48725269 NA -0.28 -5.68 -0.3 2.89e-8 Platelet count; LUSC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg26727032 chr16:67993705 SLC12A4 -0.45 -5.94 -0.31 7.32e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2425143 1.000 rs11699044 chr20:34312713 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.57 6.2 0.32 1.65e-9 Blood protein levels; LUSC cis rs72781680 0.716 rs2712071 chr2:23990419 A/G cg08917208 chr2:24149416 ATAD2B 0.59 6.68 0.34 1.02e-10 Lymphocyte counts; LUSC cis rs8114671 0.562 rs2273683 chr20:33509523 C/T cg24642439 chr20:33292090 TP53INP2 0.43 6.19 0.32 1.76e-9 Height; LUSC cis rs7202877 0.706 rs37602 chr16:75505046 C/T cg03315344 chr16:75512273 CHST6 -0.4 -5.88 -0.31 1.01e-8 Type 2 diabetes;Type 1 diabetes; LUSC cis rs11098499 0.820 rs6829903 chr4:120506884 C/T cg24375607 chr4:120327624 NA 0.76 11.41 0.53 1.06e-25 Corneal astigmatism; LUSC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg06713675 chr4:122721982 EXOSC9 -0.46 -8.06 -0.4 1.39e-14 Type 2 diabetes; LUSC cis rs740160 0.558 rs68164591 chr7:98904440 C/T cg24650262 chr7:98904301 NA 0.61 6.3 0.33 9.42e-10 Dehydroepiandrosterone sulphate levels; LUSC cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.71 11.27 0.52 3.59e-25 Colorectal cancer; LUSC cis rs2708377 0.858 rs2599399 chr12:11283163 G/A cg20188490 chr12:11080457 PRH2;PRR4;PRH1 -0.76 -7.77 -0.39 9.9e-14 Bitter taste perception; LUSC cis rs7980687 0.628 rs2851443 chr12:123694250 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.36 -6.43 -0.33 4.31e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs7189233 0.955 rs60420081 chr16:53520804 A/G cg04059762 chr16:53544020 NA -0.32 -5.81 -0.3 1.45e-8 Intelligence (multi-trait analysis); LUSC cis rs9467773 1.000 rs9467797 chr6:26568473 A/T cg09904177 chr6:26538194 HMGN4 0.76 14.14 0.61 6.79e-36 Intelligence (multi-trait analysis); LUSC cis rs9837602 1.000 rs7616988 chr3:99701134 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 5.85 0.3 1.18e-8 Breast cancer; LUSC cis rs72945132 0.882 rs947812 chr11:70209169 C/T cg00319359 chr11:70116639 PPFIA1 0.58 5.7 0.3 2.65e-8 Coronary artery disease; LUSC cis rs4834770 1.000 rs878374 chr4:120237564 A/G cg24375607 chr4:120327624 NA 0.4 5.73 0.3 2.28e-8 Blood protein levels; LUSC cis rs6845621 0.866 rs9992468 chr4:18935230 A/G cg12196642 chr4:18937545 NA -0.36 -6.76 -0.35 6.14e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs8113142 0.614 rs11083645 chr19:29214000 C/G cg04546413 chr19:29218101 NA -0.4 -5.82 -0.3 1.38e-8 Femoral neck bone geometry and menarche (age at onset); LUSC cis rs116988415 0.584 rs747858 chr14:65239772 G/A cg00114569 chr14:65239327 SPTB 0.7 6.78 0.35 5.46e-11 Daytime sleep phenotypes; LUSC cis rs66887589 0.660 rs4833613 chr4:120150156 A/C cg13609457 chr4:120235615 NA -0.36 -5.73 -0.3 2.2e-8 Diastolic blood pressure; LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03352830 chr11:487213 PTDSS2 0.74 8.84 0.44 5.49e-17 Body mass index; LUSC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg07701084 chr6:150067640 NUP43 0.55 8.45 0.42 9.18e-16 Lung cancer; LUSC cis rs9388451 0.626 rs1268074 chr6:126107791 G/C cg05901451 chr6:126070800 HEY2 -0.76 -12.92 -0.58 2.96e-31 Brugada syndrome; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg17524151 chr16:475494 RAB11FIP3 -0.35 -5.98 -0.31 5.67e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs13089785 1.000 rs2332682 chr3:123654633 C/T cg02012769 chr3:123398346 MYLK 0.34 6.43 0.33 4.44e-10 Intelligence (multi-trait analysis); LUSC cis rs4889911 0.544 rs1285271 chr17:77834197 C/T cg00646381 chr17:77835854 NA -0.56 -8.33 -0.41 2.17e-15 Electroencephalogram traits; LUSC cis rs7917772 0.582 rs10786684 chr10:104323028 A/C cg05855489 chr10:104503620 C10orf26 0.48 7.37 0.37 1.33e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg08999081 chr20:33150536 PIGU 0.44 8.14 0.41 7.85e-15 Coronary artery disease; LUSC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg00814883 chr7:100076585 TSC22D4 -0.75 -10.25 -0.49 1.27e-21 Platelet count; LUSC trans rs911555 0.755 rs12436729 chr14:103929889 G/C cg17675199 chr6:35436792 RPL10A -0.43 -6.42 -0.33 4.61e-10 Intelligence (multi-trait analysis); LUSC cis rs4470077 1.000 rs4470077 chr14:55897538 A/G cg04306507 chr14:55594613 LGALS3 0.37 5.7 0.3 2.68e-8 Platelet count; LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg21782813 chr7:2030301 MAD1L1 0.46 7.59 0.38 3.32e-13 Bipolar disorder and schizophrenia; LUSC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg07701084 chr6:150067640 NUP43 0.53 7.85 0.39 5.88e-14 Lung cancer; LUSC cis rs79149102 0.579 rs76900720 chr15:75348895 A/T cg09165964 chr15:75287851 SCAMP5 -0.84 -7.69 -0.39 1.67e-13 Lung cancer; LUSC cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg23711669 chr6:146136114 FBXO30 0.86 15.54 0.65 2.4e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs9325144 0.581 rs6582564 chr12:38671282 G/A cg26384229 chr12:38710491 ALG10B -0.67 -10.52 -0.5 1.46e-22 Morning vs. evening chronotype; LUSC cis rs950169 0.580 rs11636189 chr15:85193554 G/A cg17507749 chr15:85114479 UBE2QP1 0.59 7.52 0.38 5.07e-13 Schizophrenia; LUSC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg23131131 chr22:24373011 LOC391322 0.41 6.0 0.31 5.24e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs8031584 0.672 rs17227989 chr15:31293774 T/C cg08109568 chr15:31115862 NA -0.58 -7.04 -0.36 1.07e-11 Huntington's disease progression; LUSC cis rs7223966 1.000 rs8066719 chr17:61825764 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.16 0.32 2.13e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg08439880 chr3:133502540 NA -0.33 -6.02 -0.31 4.66e-9 Iron status biomarkers; LUSC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg03517284 chr6:25882590 NA 0.65 11.4 0.53 1.23e-25 Blood metabolite levels; LUSC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg11764359 chr7:65958608 NA 0.63 9.49 0.46 4.52e-19 Calcium levels; LUSC cis rs17030434 0.953 rs76442373 chr4:154694783 G/A cg14289246 chr4:154710475 SFRP2 -0.52 -6.79 -0.35 5.14e-11 Electrocardiographic conduction measures; LUSC cis rs1185460 0.967 rs1184902 chr11:118945337 A/G cg23280166 chr11:118938394 VPS11 0.47 7.25 0.37 2.9e-12 Coronary artery disease; LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.67 0.39 1.85e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2439831 0.850 rs12441984 chr15:44126285 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.74 0.35 7.17e-11 Lung cancer in ever smokers; LUSC cis rs10504073 0.647 rs62507252 chr8:50028795 C/G cg00325661 chr8:49890786 NA 0.61 9.5 0.46 4.31e-19 Blood metabolite ratios; LUSC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg05623727 chr3:50126028 RBM5 -0.36 -6.85 -0.35 3.61e-11 Body mass index; LUSC cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.53 -0.38 4.77e-13 Personality dimensions; LUSC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg21138405 chr5:131827807 IRF1 0.35 6.16 0.32 2.13e-9 Breast cancer;Mosquito bite size; LUSC cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg24375607 chr4:120327624 NA 0.78 11.4 0.53 1.21e-25 Corneal astigmatism; LUSC cis rs1577917 0.958 rs2324817 chr6:86462654 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -8.53 -0.42 5.22e-16 Response to antipsychotic treatment; LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18404041 chr3:52824283 ITIH1 -0.46 -8.72 -0.43 1.35e-16 Electroencephalogram traits; LUSC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg03676636 chr4:99064102 C4orf37 0.35 7.8 0.39 7.75e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs9815354 0.812 rs17219090 chr3:42051952 G/C cg03022575 chr3:42003672 ULK4 0.61 6.48 0.33 3.28e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.55 -8.29 -0.41 2.85e-15 Lymphocyte counts; LUSC cis rs9462027 0.628 rs7739003 chr6:34800329 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.09e-8 Systemic lupus erythematosus; LUSC cis rs11785400 0.793 rs2976400 chr8:143743611 G/A cg24634471 chr8:143751801 JRK 0.5 7.16 0.36 5.23e-12 Schizophrenia; LUSC cis rs6961069 0.935 rs819435 chr7:80224372 T/G cg04458919 chr7:80252533 CD36 -0.36 -6.67 -0.34 1.09e-10 Platelet count; LUSC cis rs870825 0.616 rs35818632 chr4:185649661 G/T cg04058563 chr4:185651563 MLF1IP 0.82 12.25 0.56 9.46e-29 Blood protein levels; LUSC cis rs2559856 0.967 rs7970837 chr12:102081576 A/G cg12924262 chr12:102091054 CHPT1 0.42 5.7 0.3 2.67e-8 Blood protein levels; LUSC cis rs4132509 0.793 rs10927046 chr1:243801190 T/C cg21452805 chr1:244014465 NA 0.58 5.76 0.3 1.94e-8 RR interval (heart rate); LUSC cis rs62400317 0.762 rs756 chr6:44795772 C/T cg18551225 chr6:44695536 NA -0.46 -7.37 -0.37 1.34e-12 Total body bone mineral density; LUSC cis rs78663649 0.908 rs79641498 chr19:16521143 C/A cg05286348 chr19:16641544 CHERP -0.61 -6.01 -0.31 4.84e-9 White blood cell count; LUSC cis rs61931739 0.517 rs12367881 chr12:34175508 T/C cg06521331 chr12:34319734 NA -0.45 -7.37 -0.37 1.36e-12 Morning vs. evening chronotype; LUSC cis rs5753037 0.838 rs140145 chr22:30178305 C/T cg11564601 chr22:30592435 NA 0.34 6.33 0.33 7.78e-10 Type 1 diabetes; LUSC cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg03433033 chr1:76189801 ACADM -0.46 -6.93 -0.35 2.12e-11 Daytime sleep phenotypes; LUSC cis rs868036 0.718 rs3784710 chr15:68072458 T/C cg05925327 chr15:68127851 NA -0.44 -7.12 -0.36 6.79e-12 Restless legs syndrome; LUSC cis rs1775715 0.966 rs1639132 chr10:32301260 G/A cg18675610 chr10:32216311 ARHGAP12 -0.29 -6.08 -0.32 3.22e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs921968 0.643 rs864990 chr2:219494037 G/A cg02176678 chr2:219576539 TTLL4 0.6 10.84 0.51 1.18e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs4595586 0.525 rs12809307 chr12:39365927 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.1 0.32 2.93e-9 Morning vs. evening chronotype; LUSC cis rs6121246 0.559 rs1484994 chr20:30305975 A/G cg13852791 chr20:30311386 BCL2L1 0.93 14.46 0.62 3.86e-37 Mean corpuscular hemoglobin; LUSC trans rs208520 0.837 rs208489 chr6:66927584 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -13.92 -0.61 4.89e-35 Exhaled nitric oxide output; LUSC cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.56 0.38 3.9e-13 Colorectal cancer; LUSC cis rs10761482 0.500 rs6479716 chr10:62302558 T/C cg18175470 chr10:62150864 ANK3 -0.47 -6.85 -0.35 3.63e-11 Schizophrenia; LUSC cis rs7712401 0.601 rs185009 chr5:122273767 A/G cg19077854 chr5:122220652 SNX24 0.42 9.32 0.45 1.68e-18 Mean platelet volume; LUSC cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg05347473 chr6:146136440 FBXO30 0.45 7.48 0.38 6.47e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs559928 0.606 rs11231710 chr11:63925743 A/G cg05555928 chr11:63887634 MACROD1 -0.52 -6.35 -0.33 7.06e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs2295359 1.000 rs11209006 chr1:67619259 T/G cg03340356 chr1:67600835 NA 0.39 6.45 0.33 3.81e-10 Psoriasis; LUSC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg13319975 chr6:146136371 FBXO30 0.54 8.27 0.41 3.17e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7481584 0.962 rs11603638 chr11:2990526 G/A cg08508325 chr11:3079039 CARS 0.3 5.89 0.31 9.58e-9 Calcium levels; LUSC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg00012203 chr2:219082015 ARPC2 0.7 11.53 0.53 4.08e-26 Colorectal cancer; LUSC cis rs4727027 0.704 rs12704083 chr7:148909759 G/A cg23583168 chr7:148888333 NA -0.91 -17.35 -0.69 1.58e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7119 0.717 rs12901732 chr15:77818933 G/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.61 -0.34 1.53e-10 Type 2 diabetes; LUSC cis rs6906287 0.647 rs12215793 chr6:118956857 A/T cg21191810 chr6:118973309 C6orf204 0.32 5.84 0.3 1.24e-8 Electrocardiographic conduction measures; LUSC cis rs2795502 0.564 rs72777187 chr10:43432224 C/T cg08461752 chr10:43522343 NA -0.56 -6.67 -0.34 1.06e-10 Blood protein levels; LUSC cis rs4478858 0.684 rs11578407 chr1:31728543 A/G cg00250761 chr1:31883323 NA -0.35 -8.43 -0.42 1.09e-15 Alcohol dependence; LUSC cis rs12210905 0.925 rs72838260 chr6:27008168 T/C cg23155468 chr6:27110703 HIST1H2BK -0.65 -5.73 -0.3 2.24e-8 Hip circumference adjusted for BMI; LUSC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg23758822 chr17:41437982 NA 0.98 18.49 0.71 4.55e-53 Menopause (age at onset); LUSC cis rs7264396 0.623 rs11698601 chr20:34205035 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -7.18 -0.37 4.64e-12 Total cholesterol levels; LUSC trans rs1997103 0.954 rs2177809 chr7:55378125 T/C cg20935933 chr6:143382018 AIG1 0.51 7.16 0.36 5.08e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg25456477 chr12:86230367 RASSF9 0.44 7.67 0.39 1.92e-13 Major depressive disorder; LUSC cis rs34779708 0.931 rs6481935 chr10:35342959 C/T cg03585969 chr10:35415529 CREM 0.6 8.84 0.44 5.75e-17 Inflammatory bowel disease;Crohn's disease; LUSC trans rs28573326 0.629 rs1438119 chr4:166348346 T/C cg13437084 chr2:26467494 HADHB;HADHA -0.59 -6.76 -0.35 6.11e-11 Pelvic organ prolapse (moderate/severe); LUSC cis rs1403694 0.695 rs11927941 chr3:186433046 A/G cg12454167 chr3:186435060 KNG1 0.34 8.42 0.42 1.16e-15 Blood protein levels; LUSC cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.19 0.37 4.36e-12 Cognitive ability; LUSC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg03676636 chr4:99064102 C4orf37 0.36 8.1 0.41 1.07e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs662064 0.962 rs660725 chr1:10557544 A/G cg17425144 chr1:10567563 PEX14 0.35 5.69 0.3 2.85e-8 Asthma; LUSC cis rs2219968 0.962 rs9643733 chr8:78950551 G/T cg00738934 chr8:78996279 NA 0.37 6.65 0.34 1.21e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6693567 0.545 rs1932934 chr1:150449195 G/A cg15654264 chr1:150340011 RPRD2 0.43 6.85 0.35 3.45e-11 Migraine; LUSC trans rs8002861 0.870 rs4942254 chr13:44451820 C/T cg12856521 chr11:46389249 DGKZ 0.4 6.45 0.33 3.82e-10 Leprosy; LUSC cis rs11250464 0.833 rs2387653 chr10:1407826 A/G cg08668359 chr10:1443807 ADARB2 -0.42 -6.28 -0.32 1.08e-9 Radiation response; LUSC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg12311346 chr5:56204834 C5orf35 -1.09 -16.71 -0.67 5.34e-46 Initial pursuit acceleration; LUSC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg14582100 chr15:45693742 SPATA5L1 0.57 10.61 0.5 7.49e-23 Homoarginine levels; LUSC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg12963246 chr6:28129442 ZNF389 0.41 5.74 0.3 2.15e-8 Depression; LUSC cis rs1965732 1.000 rs6707320 chr2:3708966 A/G cg00999904 chr2:3704751 ALLC -0.34 -6.08 -0.32 3.34e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05794227 chr16:56484937 OGFOD1;NUDT21 -0.41 -6.07 -0.32 3.5e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9309473 0.847 rs13538 chr2:73868328 A/G cg20560298 chr2:73613845 ALMS1 -0.42 -5.95 -0.31 6.71e-9 Metabolite levels; LUSC cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg18758796 chr5:131593413 PDLIM4 0.35 6.03 0.31 4.46e-9 Blood metabolite levels; LUSC cis rs3099143 1.000 rs3106378 chr15:77110524 A/C cg21673338 chr15:77095150 SCAPER -0.78 -7.37 -0.37 1.33e-12 Recalcitrant atopic dermatitis; LUSC cis rs727505 0.954 rs17327014 chr7:124709349 C/T cg23710748 chr7:124431027 NA -0.41 -7.15 -0.36 5.55e-12 Lewy body disease; LUSC cis rs6977660 0.652 rs10274428 chr7:19850592 C/T cg05791153 chr7:19748676 TWISTNB 0.64 6.74 0.35 7.08e-11 Thyroid stimulating hormone; LUSC trans rs7618314 0.571 rs16854821 chr3:108500645 G/C cg05749855 chr16:89472771 ANKRD11 0.59 6.0 0.31 5.2e-9 Airway responsiveness in chronic obstructive pulmonary disease; LUSC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.15 0.32 2.17e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg10729496 chr3:10149963 C3orf24 0.58 7.54 0.38 4.37e-13 Alzheimer's disease; LUSC trans rs3749237 1.000 rs11130214 chr3:49735746 C/G cg21659725 chr3:3221576 CRBN -0.61 -9.07 -0.44 1.05e-17 Resting heart rate; LUSC cis rs909341 0.868 rs2315009 chr20:62344140 C/G cg09650180 chr20:62225654 GMEB2 -0.44 -5.79 -0.3 1.62e-8 Atopic dermatitis; LUSC cis rs35146811 0.696 rs1727124 chr7:99804104 T/G cg22906224 chr7:99728672 NA -0.46 -6.5 -0.34 2.92e-10 Coronary artery disease; LUSC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg17294928 chr15:75287854 SCAMP5 0.41 5.98 0.31 5.88e-9 Breast cancer; LUSC cis rs782590 0.764 rs2586969 chr2:55829392 G/C cg03859395 chr2:55845619 SMEK2 0.81 14.18 0.61 4.7e-36 Metabolic syndrome; LUSC cis rs377070 0.966 rs309419 chr4:123624001 C/G cg10495464 chr4:123653540 BBS12;LOC729338 0.47 6.87 0.35 3.16e-11 Mosquito bite size; LUSC cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg00631329 chr6:26305371 NA -0.45 -8.62 -0.43 2.78e-16 Educational attainment; LUSC cis rs950776 0.518 rs12900783 chr15:78815523 G/A cg06917634 chr15:78832804 PSMA4 0.83 14.99 0.63 3.39e-39 Sudden cardiac arrest; LUSC cis rs6582630 0.539 rs35114325 chr12:38320886 G/T cg26384229 chr12:38710491 ALG10B -0.53 -7.82 -0.39 6.96e-14 Drug-induced liver injury (flucloxacillin); LUSC cis rs6547741 0.967 rs4665995 chr2:27813827 T/G cg27432699 chr2:27873401 GPN1 0.8 15.0 0.63 3.16e-39 Oral cavity cancer; LUSC trans rs4714291 0.963 rs940352 chr6:40113614 C/T cg02267698 chr19:7991119 CTXN1 -0.53 -7.38 -0.37 1.26e-12 Strep throat; LUSC cis rs13064411 0.660 rs11916690 chr3:113012343 A/C cg18753928 chr3:113234510 CCDC52 -0.43 -6.21 -0.32 1.54e-9 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs3845702 1.000 rs3845702 chr2:180848488 A/C cg01881094 chr2:180872142 CWC22 0.81 10.66 0.5 4.83e-23 Schizophrenia; LUSC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.3 -0.33 9.33e-10 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs1018836 0.923 rs10956749 chr8:91621573 G/A cg16814680 chr8:91681699 NA -0.77 -12.99 -0.58 1.66e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC trans rs1941687 0.563 rs2032189 chr18:31332200 T/A cg13755796 chr4:20253514 NA -0.39 -6.05 -0.31 3.84e-9 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs6430585 0.591 rs1374330 chr2:136420908 A/C cg07169764 chr2:136633963 MCM6 1.04 13.36 0.59 6.43e-33 Corneal structure; LUSC cis rs3755132 0.929 rs4668937 chr2:15736029 G/A cg12888861 chr2:15731646 DDX1 0.5 7.34 0.37 1.68e-12 Wilms tumor; LUSC cis rs9837602 0.938 rs17393059 chr3:99761908 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 6.17 0.32 2.01e-9 Breast cancer; LUSC cis rs12579753 0.917 rs71466033 chr12:82242187 C/T cg21231944 chr12:82153410 PPFIA2 -0.39 -5.9 -0.31 9.01e-9 Resting heart rate; LUSC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg08917208 chr2:24149416 ATAD2B 0.55 6.16 0.32 2.04e-9 Lymphocyte counts; LUSC cis rs7095944 0.584 rs11245347 chr10:126427037 G/T cg08799069 chr10:126477246 METTL10 -0.43 -6.67 -0.34 1.09e-10 Asthma; LUSC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.59 7.57 0.38 3.58e-13 Age-related macular degeneration (geographic atrophy); LUSC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.62 9.46 0.46 5.51e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4843747 0.671 rs28451517 chr16:88109127 A/C cg17633681 chr16:88106987 BANP 0.49 9.04 0.44 1.28e-17 Menopause (age at onset); LUSC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg05425664 chr17:57184151 TRIM37 -0.55 -8.15 -0.41 7.21e-15 Intelligence (multi-trait analysis); LUSC cis rs3125734 0.633 rs3902162 chr10:64041817 C/T cg09941381 chr10:64027924 RTKN2 -0.39 -7.13 -0.36 6.25e-12 Rheumatoid arthritis; LUSC cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg13010199 chr12:38710504 ALG10B 0.64 9.85 0.47 2.98e-20 Drug-induced liver injury (flucloxacillin); LUSC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg02569458 chr12:86230093 RASSF9 -0.58 -9.78 -0.47 5.09e-20 Major depressive disorder; LUSC cis rs6163 0.508 rs11191381 chr10:104493444 C/T cg05855489 chr10:104503620 C10orf26 0.73 11.34 0.53 2e-25 Waist circumference;Hip circumference; LUSC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.55 7.17 0.37 4.87e-12 Age-related macular degeneration (geographic atrophy); LUSC cis rs6681460 0.932 rs536410 chr1:67191084 C/T cg02459107 chr1:67143332 SGIP1 0.46 8.67 0.43 1.89e-16 Presence of antiphospholipid antibodies; LUSC cis rs1153858 0.943 rs1145079 chr15:45681761 T/C cg14582100 chr15:45693742 SPATA5L1 0.57 10.33 0.49 6.78e-22 Homoarginine levels; LUSC cis rs708547 0.647 rs1277308 chr4:57897864 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.93 -0.31 7.72e-9 Response to bleomycin (chromatid breaks); LUSC cis rs208515 0.525 rs12193034 chr6:66677866 C/T cg07460842 chr6:66804631 NA 1.05 14.32 0.62 1.33e-36 Exhaled nitric oxide levels; LUSC cis rs1113500 0.933 rs61797345 chr1:108623728 G/A cg06207961 chr1:108661230 NA 0.4 7.49 0.38 6.17e-13 Growth-regulated protein alpha levels; LUSC cis rs9372498 0.536 rs62422221 chr6:118925581 T/C cg18833306 chr6:118973337 C6orf204 -0.45 -5.68 -0.3 2.89e-8 Diastolic blood pressure; LUSC cis rs7809950 0.817 rs2712230 chr7:107294151 G/A cg23024343 chr7:107201750 COG5 0.58 8.2 0.41 5.37e-15 Coronary artery disease; LUSC cis rs763121 0.962 rs909564 chr22:39126508 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.74 0.57 1.43e-30 Menopause (age at onset); LUSC cis rs926938 0.563 rs360652 chr1:115445478 C/T cg12756093 chr1:115239321 AMPD1 0.41 6.16 0.32 2.04e-9 Autism; LUSC trans rs11935423 0.778 rs3816873 chr4:100504664 T/C cg02164153 chr5:172068145 NEURL1B -0.47 -6.05 -0.31 3.97e-9 Gut microbiome composition (summer); LUSC cis rs6138458 0.961 rs227625 chr20:24911618 T/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.94 -0.36 2.02e-11 Blood protein levels; LUSC cis rs243505 0.691 rs243480 chr7:148452905 G/T cg09806900 chr7:148480153 CUL1 -0.52 -6.98 -0.36 1.55e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7267979 0.706 rs6138542 chr20:25207773 C/A cg08601574 chr20:25228251 PYGB 0.49 7.59 0.38 3.28e-13 Liver enzyme levels (alkaline phosphatase); LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg07362569 chr17:61921086 SMARCD2 -0.3 -6.03 -0.31 4.47e-9 Prudent dietary pattern; LUSC cis rs8060686 0.623 rs7204208 chr16:68069416 A/G cg26727032 chr16:67993705 SLC12A4 -0.42 -6.6 -0.34 1.65e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs8077577 0.895 rs3088233 chr17:18112675 C/T cg16794390 chr17:18148240 FLII 0.41 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -12.23 -0.56 1.08e-28 Alzheimer's disease; LUSC cis rs2302729 0.858 rs10431348 chr12:2784534 A/G cg19945202 chr12:2788847 CACNA1C -0.42 -5.78 -0.3 1.71e-8 Sleep quality; LUSC trans rs11681884 0.786 rs1992761 chr2:113810286 C/T cg21236845 chr5:98115329 RGMB 0.77 5.96 0.31 6.27e-9 Stroke; LUSC cis rs7296418 0.961 rs1790121 chr12:123604492 G/A cg05973401 chr12:123451056 ABCB9 0.62 8.94 0.44 2.65e-17 Platelet count; LUSC cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.2 0.37 4.05e-12 Motion sickness; LUSC cis rs10465746 0.967 rs6670658 chr1:84461268 A/G cg10977910 chr1:84465055 TTLL7 0.43 6.35 0.33 6.9e-10 Obesity-related traits; LUSC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg07362569 chr17:61921086 SMARCD2 0.38 7.56 0.38 3.97e-13 Prudent dietary pattern; LUSC cis rs225245 0.791 rs8067294 chr17:34027964 T/C cg05299278 chr17:33885742 SLFN14 0.29 6.44 0.33 4.11e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs2731664 0.792 rs335435 chr5:176867943 A/G cg23176889 chr5:176863531 GRK6 -0.65 -12.99 -0.58 1.66e-31 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.629 rs11684516 chr2:100949883 C/A cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs9300255 0.664 rs7306755 chr12:123767929 G/A cg13010344 chr12:123464640 ARL6IP4 0.55 6.69 0.34 9.37e-11 Neutrophil percentage of white cells; LUSC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg02782426 chr3:40428986 ENTPD3 0.32 6.17 0.32 2.01e-9 Renal cell carcinoma; LUSC cis rs12908161 1.000 rs35524990 chr15:85258203 T/C cg17173187 chr15:85201210 NMB 0.51 9.69 0.47 9.71e-20 Schizophrenia; LUSC cis rs10979 0.964 rs9496682 chr6:143898805 A/G cg25407410 chr6:143891975 LOC285740 -0.75 -11.97 -0.55 1.06e-27 Hypospadias; LUSC cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg05707623 chr12:122985044 ZCCHC8 -0.63 -8.51 -0.42 5.81e-16 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg11079866 chr4:75858172 PARM1 0.43 6.15 0.32 2.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7772486 0.777 rs1546966 chr6:146386018 G/T cg23711669 chr6:146136114 FBXO30 0.73 11.9 0.55 1.8e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs17227506 0.704 rs6530649 chr8:13448112 A/G cg03566418 chr8:13424080 C8orf48 -0.4 -6.12 -0.32 2.61e-9 Nonsyndromic cleft lip with cleft palate; LUSC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs7949030 0.929 rs11231173 chr11:62418921 T/A cg11742103 chr11:62369870 EML3;MTA2 0.48 8.04 0.4 1.61e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4919694 1.000 rs11191439 chr10:104638723 C/T cg04362960 chr10:104952993 NT5C2 -1.14 -13.32 -0.59 9.63e-33 Arsenic metabolism; LUSC cis rs9311676 0.656 rs11130636 chr3:58380098 C/A cg13750441 chr3:58318267 PXK 0.36 7.06 0.36 9.88e-12 Systemic lupus erythematosus; LUSC cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg16339924 chr4:17578868 LAP3 -0.56 -8.18 -0.41 5.82e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg11812906 chr14:75593930 NEK9 0.67 11.56 0.53 3.23e-26 Height; LUSC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg06740227 chr12:86229804 RASSF9 0.44 7.11 0.36 7.2e-12 Major depressive disorder; LUSC trans rs6076960 0.623 rs6038407 chr20:6267326 A/G cg17788362 chr6:86352627 SYNCRIP 0.52 7.62 0.38 2.6e-13 Smooth-surface caries; LUSC cis rs9660992 0.674 rs72745221 chr1:205262337 G/A cg21545522 chr1:205238299 TMCC2 0.5 9.45 0.46 5.97e-19 Mean corpuscular volume;Mean platelet volume; LUSC trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.91 -0.35 2.46e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg12219531 chr12:120966889 COQ5 0.6 8.02 0.4 1.85e-14 High light scatter reticulocyte count; LUSC cis rs250677 0.524 rs417413 chr5:148452726 T/C cg18129178 chr5:148520854 ABLIM3 -0.59 -9.82 -0.47 3.6e-20 Breast cancer; LUSC cis rs4363385 0.626 rs11205192 chr1:153062767 C/T cg00922841 chr1:152955080 SPRR1A -0.35 -6.14 -0.32 2.35e-9 Inflammatory skin disease; LUSC cis rs7909074 1.000 rs1408814 chr10:45399088 A/G cg05187965 chr10:45406764 TMEM72 -0.37 -8.79 -0.43 8.33e-17 Mean corpuscular volume; LUSC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg14019146 chr3:50243930 SLC38A3 -0.33 -7.39 -0.38 1.16e-12 Intelligence (multi-trait analysis); LUSC trans rs747782 0.583 rs11039666 chr11:48324841 C/G cg15704280 chr7:45808275 SEPT13 0.76 6.49 0.33 3.11e-10 Intraocular pressure; LUSC cis rs2012796 0.957 rs8011477 chr14:81815587 C/T cg02996355 chr14:81879375 NA 0.46 6.53 0.34 2.48e-10 Night sleep phenotypes; LUSC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg03433033 chr1:76189801 ACADM -0.65 -8.74 -0.43 1.19e-16 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9914988 0.887 rs9895625 chr17:27108516 A/G cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs28374715 1.000 rs28374715 chr15:41563950 A/G cg18705301 chr15:41695430 NDUFAF1 -0.83 -14.15 -0.61 6e-36 Ulcerative colitis; LUSC cis rs977987 0.806 rs12448947 chr16:75462954 G/A cg03315344 chr16:75512273 CHST6 0.5 9.56 0.46 2.75e-19 Dupuytren's disease; LUSC cis rs2455601 0.638 rs3815991 chr11:9007669 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.42 6.74 0.35 6.91e-11 Schizophrenia; LUSC cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg00071950 chr4:10020882 SLC2A9 0.64 10.55 0.5 1.22e-22 Bone mineral density; LUSC cis rs17621444 0.522 rs10736278 chr10:121818149 A/G cg02041677 chr10:121771263 NA -0.32 -6.18 -0.32 1.92e-9 IgG glycosylation; LUSC trans rs60843830 1.000 rs57542652 chr2:228088 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 10.63 0.5 6.47e-23 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg11244672 chr19:19639970 YJEFN3 -0.56 -6.83 -0.35 4.13e-11 Bipolar disorder; LUSC cis rs9549367 0.724 rs7985335 chr13:113869244 G/T cg18105134 chr13:113819100 PROZ 0.65 9.97 0.48 1.14e-20 Platelet distribution width; LUSC cis rs1018836 0.847 rs2285231 chr8:91545387 G/T cg16814680 chr8:91681699 NA -0.74 -12.41 -0.56 2.5e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg15316289 chr22:50310904 ALG12;CRELD2 -0.45 -6.6 -0.34 1.66e-10 Schizophrenia; LUSC cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg13535736 chr9:111863775 C9orf5 -0.4 -6.6 -0.34 1.59e-10 Menarche (age at onset); LUSC trans rs836788 0.608 rs26784 chr5:80049892 A/G cg27031367 chr8:145510315 BOP1 -0.37 -6.07 -0.32 3.42e-9 Glomerular filtration rate (creatinine); LUSC cis rs7267979 0.545 rs6050426 chr20:25178265 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.59 10.13 0.48 3.21e-21 Liver enzyme levels (alkaline phosphatase); LUSC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg19592336 chr6:28129416 ZNF389 0.45 5.98 0.31 5.78e-9 Depression; LUSC cis rs2729354 0.768 rs2848635 chr11:57253931 T/C cg24343310 chr11:57249947 NA 0.47 8.64 0.43 2.37e-16 Blood protein levels; LUSC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.38 -0.33 6.02e-10 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; LUSC cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg18681998 chr4:17616180 MED28 0.84 15.64 0.65 9.43e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg00343986 chr7:65444356 GUSB 0.47 7.0 0.36 1.42e-11 Calcium levels; LUSC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg18404041 chr3:52824283 ITIH1 0.56 10.3 0.49 8.64e-22 Bipolar disorder; LUSC cis rs7103648 0.695 rs11039290 chr11:47572279 G/A cg20307385 chr11:47447363 PSMC3 0.87 13.64 0.6 5.7e-34 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs9443189 0.570 rs504323 chr6:76294965 A/G cg01950844 chr6:76311363 SENP6 -0.65 -6.08 -0.32 3.28e-9 Prostate cancer; LUSC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.64 8.04 0.4 1.54e-14 Lung function (FEV1/FVC); LUSC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg04369109 chr6:150039330 LATS1 -0.54 -7.88 -0.4 4.69e-14 Lung cancer; LUSC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg17279839 chr7:150038598 RARRES2 0.52 7.54 0.38 4.34e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg08859206 chr1:53392774 SCP2 -0.41 -6.72 -0.35 7.81e-11 Monocyte count; LUSC cis rs4906332 1.000 rs12896919 chr14:103956713 T/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.16 -0.36 5.08e-12 Coronary artery disease; LUSC cis rs9443189 0.570 rs276687 chr6:76429995 G/T cg01950844 chr6:76311363 SENP6 -0.7 -7.0 -0.36 1.43e-11 Prostate cancer; LUSC cis rs6681460 1.000 rs6697088 chr1:67044724 C/G cg02459107 chr1:67143332 SGIP1 -0.45 -8.05 -0.4 1.48e-14 Presence of antiphospholipid antibodies; LUSC cis rs3741798 0.614 rs61922044 chr12:12490914 G/A cg08615371 chr12:12503544 MANSC1 1.1 11.11 0.52 1.31e-24 Cerebrospinal fluid biomarker levels; LUSC trans rs8072100 0.790 rs6505048 chr17:45674998 G/A cg03886242 chr7:26192032 NFE2L3 0.41 6.49 0.33 3.03e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6489882 0.703 rs6489864 chr12:113360025 A/G cg20102336 chr12:113376681 OAS3 -0.41 -5.75 -0.3 2.02e-8 Chronic lymphocytic leukemia; LUSC cis rs2404602 0.735 rs11638767 chr15:76655938 T/C cg23625390 chr15:77176239 SCAPER -0.61 -9.56 -0.46 2.6e-19 Blood metabolite levels; LUSC cis rs28830936 0.510 rs7174099 chr15:42099059 A/G cg17847044 chr15:42102381 MAPKBP1 -0.38 -9.31 -0.45 1.81e-18 Diastolic blood pressure; LUSC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08109568 chr15:31115862 NA 0.57 8.13 0.41 8.65e-15 Huntington's disease progression; LUSC trans rs9393777 0.778 rs13212921 chr6:27205422 C/T cg06606381 chr12:133084897 FBRSL1 -0.62 -6.42 -0.33 4.65e-10 Intelligence (multi-trait analysis); LUSC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg08917208 chr2:24149416 ATAD2B 0.53 5.88 0.31 1e-8 Lymphocyte counts; LUSC cis rs7089973 0.604 rs3758603 chr10:116605368 T/C cg23260525 chr10:116636907 FAM160B1 0.43 9.24 0.45 3.04e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7575217 0.740 rs13392166 chr2:101768104 T/C cg23907051 chr2:101730305 TBC1D8 -0.3 -7.85 -0.39 5.65e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs6051080 1 rs6051080 chr20:25975674 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.49 8.23 0.41 4.29e-15 Colorectal or endometrial cancer; LUSC cis rs6594499 0.872 rs7732974 chr5:110455381 T/C cg04022379 chr5:110408740 TSLP 0.43 6.39 0.33 5.73e-10 Allergic disease (asthma, hay fever or eczema); LUSC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg14895029 chr7:2775587 GNA12 -0.36 -5.66 -0.3 3.31e-8 Height; LUSC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg21573476 chr21:45109991 RRP1B -0.36 -5.79 -0.3 1.6e-8 Mean corpuscular volume; LUSC cis rs6969780 1.000 rs739734 chr7:27159405 C/T cg26364809 chr7:27145159 NA -0.61 -6.16 -0.32 2.12e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs9326248 0.581 rs10892076 chr11:116988936 G/A cg20608306 chr11:116969690 SIK3 0.37 6.9 0.35 2.68e-11 Blood protein levels; LUSC cis rs6690583 0.623 rs1371142 chr1:85455373 A/T cg22153463 chr1:85462885 MCOLN2 0.61 5.91 0.31 8.56e-9 Serum sulfate level; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg11494091 chr17:61959527 GH2 0.62 13.17 0.58 3.4e-32 Prudent dietary pattern; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22357700 chr19:11805638 NA 0.41 6.47 0.33 3.5e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs854765 0.583 rs7207043 chr17:17819188 A/G cg09796270 chr17:17721594 SREBF1 0.43 7.63 0.39 2.41e-13 Total body bone mineral density; LUSC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.34 0.33 7.63e-10 Lung cancer; LUSC trans rs11098499 0.954 rs67265404 chr4:120359270 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.32 0.33 8.55e-10 Corneal astigmatism; LUSC cis rs5756813 0.754 rs3788529 chr22:38158709 A/G cg06521852 chr22:38141419 TRIOBP 0.45 6.73 0.35 7.34e-11 Optic cup area;Vertical cup-disc ratio; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg09704166 chr2:114031854 PAX8;LOC440839 -0.5 -7.09 -0.36 8.18e-12 Renal function-related traits (BUN); LUSC trans rs11227306 0.934 rs7102454 chr11:65594820 C/T cg17712092 chr4:129076599 LARP1B -0.62 -8.3 -0.41 2.68e-15 DNA methylation (variation); LUSC cis rs11945232 1.000 rs28406846 chr4:88343468 C/G cg23841344 chr4:88312519 HSD17B11 -0.67 -10.33 -0.49 6.62e-22 Intelligence (multi-trait analysis); LUSC cis rs3018712 0.532 rs2513280 chr11:68416907 C/G cg22747802 chr11:68417633 NA -0.41 -5.65 -0.3 3.5e-8 Total body bone mineral density; LUSC cis rs721399 0.568 rs34987019 chr8:18274443 T/C cg18736775 chr8:18248649 NAT2 -0.55 -6.74 -0.35 7.12e-11 Blood metabolite levels; LUSC cis rs8048589 0.604 rs2175020 chr16:12219190 C/T cg02910054 chr16:12241554 SNX29 0.45 6.15 0.32 2.26e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs1190552 0.841 rs56144019 chr14:102949731 G/A cg18135206 chr14:102964638 TECPR2 0.47 5.71 0.3 2.56e-8 Blood protein levels; LUSC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg21573476 chr21:45109991 RRP1B -0.37 -6.04 -0.31 4.2e-9 Mean corpuscular volume; LUSC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg19774624 chr17:42201019 HDAC5 -0.7 -10.65 -0.5 5.47e-23 Total body bone mineral density; LUSC trans rs11098499 0.954 rs10006877 chr4:120242793 C/T cg25214090 chr10:38739885 LOC399744 0.55 8.0 0.4 2.05e-14 Corneal astigmatism; LUSC cis rs7212590 0.748 rs7213697 chr17:57903041 G/C cg10252138 chr17:58120427 NA -0.74 -7.0 -0.36 1.37e-11 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; LUSC trans rs7824557 0.527 rs11785394 chr8:11238029 C/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.69 -0.34 9.15e-11 Retinal vascular caliber; LUSC cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.97 17.92 0.7 8.94e-51 Chronic sinus infection; LUSC cis rs2933343 0.729 rs1680785 chr3:128644816 C/T cg11901034 chr3:128598214 ACAD9 -0.41 -6.47 -0.33 3.54e-10 IgG glycosylation; LUSC cis rs10782582 0.593 rs77208152 chr1:76124255 T/C cg03433033 chr1:76189801 ACADM -0.45 -6.84 -0.35 3.86e-11 Daytime sleep phenotypes; LUSC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.46 -7.37 -0.37 1.34e-12 Bipolar disorder; LUSC cis rs7119 0.745 rs11632602 chr15:77809764 C/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.76 -0.35 6.17e-11 Type 2 diabetes; LUSC cis rs7188861 0.597 rs12918017 chr16:11402350 G/A cg00044050 chr16:11439710 C16orf75 0.59 6.18 0.32 1.84e-9 HDL cholesterol; LUSC cis rs61931739 0.500 rs6488209 chr12:34319309 A/G cg06521331 chr12:34319734 NA -0.53 -9.23 -0.45 3.08e-18 Morning vs. evening chronotype; LUSC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg12311346 chr5:56204834 C5orf35 -0.95 -13.74 -0.6 2.42e-34 Initial pursuit acceleration; LUSC cis rs701145 0.730 rs701141 chr3:154061053 G/A cg17054900 chr3:154042577 DHX36 0.8 8.37 0.42 1.56e-15 Coronary artery disease; LUSC cis rs7000551 0.606 rs13256933 chr8:22267199 T/G cg12081754 chr8:22256438 SLC39A14 0.94 14.61 0.62 9.9e-38 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs11122272 0.735 rs2808600 chr1:231534723 T/C cg06096015 chr1:231504339 EGLN1 0.58 10.37 0.49 5.03e-22 Hemoglobin concentration; LUSC cis rs6424115 1.000 rs6424115 chr1:24153231 A/G cg10978503 chr1:24200527 CNR2 -0.51 -11.53 -0.53 4.09e-26 Immature fraction of reticulocytes; LUSC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg08067268 chr2:26466485 HADHB;HADHA 0.52 7.54 0.38 4.6e-13 Gut microbiome composition (summer); LUSC cis rs12421382 0.778 rs12804063 chr11:109495509 C/T cg16359550 chr11:109292809 C11orf87 -0.35 -5.92 -0.31 8e-9 Schizophrenia; LUSC cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg03146154 chr1:46216737 IPP 0.52 7.7 0.39 1.53e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg04522931 chr7:30324582 ZNRF2 0.38 6.3 0.33 9.26e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.48 6.91 0.35 2.53e-11 Monocyte percentage of white cells; LUSC cis rs13082711 0.522 rs3103745 chr3:27342927 T/C cg02860705 chr3:27208620 NA 0.46 8.46 0.42 8.4e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; LUSC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg13395646 chr4:1353034 KIAA1530 -0.65 -10.25 -0.49 1.32e-21 Obesity-related traits; LUSC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg09263875 chr16:632152 PIGQ 0.7 12.63 0.57 3.65e-30 Height; LUSC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg09033563 chr22:24373618 LOC391322 -0.5 -7.03 -0.36 1.19e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg15744005 chr10:104629667 AS3MT 0.31 6.61 0.34 1.51e-10 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg04287289 chr16:89883240 FANCA 0.78 13.54 0.6 1.38e-33 Vitiligo; LUSC cis rs6977660 0.714 rs10228783 chr7:19789290 C/T cg05791153 chr7:19748676 TWISTNB 0.77 8.33 0.41 2.07e-15 Thyroid stimulating hormone; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21564660 chr12:50236950 BCDIN3D -0.43 -6.28 -0.32 1.08e-9 Electrocardiographic conduction measures; LUSC cis rs2404602 0.735 rs283789 chr15:76777577 G/A cg23625390 chr15:77176239 SCAPER 0.6 9.41 0.46 8.06e-19 Blood metabolite levels; LUSC cis rs983392 0.679 rs636317 chr11:60019150 C/T cg02771260 chr11:59836817 MS4A3 0.38 6.26 0.32 1.17e-9 Alzheimer's disease (late onset); LUSC trans rs2790216 0.526 rs1199093 chr10:59896794 C/G cg05993363 chr11:15671931 NA -0.38 -6.03 -0.31 4.38e-9 Inflammatory bowel disease; LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg08470875 chr2:26401718 FAM59B -0.69 -9.49 -0.46 4.53e-19 Gut microbiome composition (summer); LUSC cis rs34779708 0.931 rs35997236 chr10:35376690 C/T cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.69 8.36 0.42 1.72e-15 Mean platelet volume; LUSC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg06481639 chr22:41940642 POLR3H 0.5 5.72 0.3 2.42e-8 Vitiligo; LUSC trans rs7567288 0.636 rs7568394 chr2:134462374 G/A cg12381416 chr3:14359266 NA 0.55 6.1 0.32 3e-9 Height; LUSC cis rs7937682 0.921 rs4534611 chr11:111440425 C/G cg19812747 chr11:111475976 SIK2 -0.53 -7.36 -0.37 1.4e-12 Primary sclerosing cholangitis; LUSC cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg27446573 chr6:127587934 RNF146 0.69 10.56 0.5 1.09e-22 Breast cancer; LUSC trans rs911555 0.755 rs12435516 chr14:103954404 T/C cg17675199 chr6:35436792 RPL10A -0.43 -6.32 -0.33 8.21e-10 Intelligence (multi-trait analysis); LUSC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg03161606 chr19:29218774 NA 0.61 9.03 0.44 1.38e-17 Methadone dose in opioid dependence; LUSC cis rs11031096 0.677 rs11031043 chr11:4145385 G/T cg18678763 chr11:4115507 RRM1 0.38 5.77 0.3 1.79e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg18404041 chr3:52824283 ITIH1 0.53 8.86 0.44 4.93e-17 Schizophrenia; LUSC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg18850127 chr7:39170497 POU6F2 0.63 9.8 0.47 4.2e-20 IgG glycosylation; LUSC cis rs62400317 0.859 rs10456121 chr6:45092545 G/A cg18551225 chr6:44695536 NA -0.42 -6.87 -0.35 3.22e-11 Total body bone mineral density; LUSC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg19920283 chr7:105172520 RINT1 0.58 6.25 0.32 1.25e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7264396 0.747 rs6058291 chr20:34247769 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.82 -0.47 3.7e-20 Total cholesterol levels; LUSC cis rs1348850 0.914 rs12693120 chr2:178283288 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.12 0.41 9e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg20887711 chr4:1340912 KIAA1530 0.44 6.6 0.34 1.63e-10 Obesity-related traits; LUSC cis rs3784262 0.679 rs4238326 chr15:58336000 C/T cg12031962 chr15:58353849 ALDH1A2 0.38 6.72 0.35 7.84e-11 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC trans rs7937682 0.883 rs2212520 chr11:111462096 C/T cg18187862 chr3:45730750 SACM1L 0.54 6.88 0.35 3.03e-11 Primary sclerosing cholangitis; LUSC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg00814883 chr7:100076585 TSC22D4 -0.67 -8.81 -0.43 6.75e-17 Platelet count; LUSC trans rs72674100 1.000 rs77899474 chr4:97952494 C/A cg09670535 chr1:18959427 PAX7 -0.62 -6.36 -0.33 6.65e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg05340658 chr4:99064831 C4orf37 0.66 11.29 0.53 3.07e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.67 -10.62 -0.5 6.81e-23 Menarche (age at onset); LUSC trans rs62103177 0.564 rs11874805 chr18:77697110 T/C cg14227996 chr4:17616232 MED28 0.67 7.19 0.37 4.17e-12 Opioid sensitivity; LUSC cis rs870825 0.655 rs67380800 chr4:185623788 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.7e-32 Blood protein levels; LUSC cis rs9790314 0.936 rs7629987 chr3:161002023 A/C cg03342759 chr3:160939853 NMD3 -0.51 -8.67 -0.43 1.87e-16 Morning vs. evening chronotype; LUSC cis rs709400 0.628 rs11621510 chr14:103869620 T/C cg10523860 chr14:103875565 MARK3 -0.39 -6.29 -0.33 1.02e-9 Body mass index; LUSC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg11645453 chr3:52864694 ITIH4 0.36 7.79 0.39 8.29e-14 Bipolar disorder; LUSC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs10435719 0.902 rs6601633 chr8:11805173 C/T cg00262122 chr8:11665843 FDFT1 -0.38 -5.72 -0.3 2.41e-8 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs7647973 0.922 rs57273516 chr3:49483074 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.52 0.38 5.17e-13 Menarche (age at onset); LUSC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg13939156 chr17:80058883 NA -0.33 -6.5 -0.33 3e-10 Life satisfaction; LUSC trans rs7374394 1.000 rs2301052 chr3:184953662 C/T cg08120831 chr12:122669186 LRRC43 0.3 6.38 0.33 5.81e-10 Cognitive performance; LUSC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg11189052 chr15:85197271 WDR73 -0.64 -9.98 -0.48 1.08e-20 P wave terminal force; LUSC trans rs731565 1.000 rs1525254 chr7:147406140 C/T cg20906291 chr6:10382103 NA -0.56 -6.17 -0.32 1.94e-9 Diabetic kidney disease; LUSC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg21643547 chr1:205240462 TMCC2 -0.51 -9.5 -0.46 4.34e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2832077 0.506 rs2832088 chr21:30158620 G/A cg24692254 chr21:30365293 RNF160 -0.54 -7.13 -0.36 6.32e-12 Cognitive test performance; LUSC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg26380479 chr7:97908229 NA -0.28 -6.25 -0.32 1.24e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2204008 0.576 rs11519979 chr12:37999413 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.91 0.51 6.74e-24 Bladder cancer; LUSC cis rs7829975 0.560 rs56094035 chr8:8551622 G/A cg15556689 chr8:8085844 FLJ10661 -0.5 -7.23 -0.37 3.37e-12 Mood instability; LUSC cis rs6840360 0.615 rs12641433 chr4:152607548 A/C cg22705602 chr4:152727874 NA -0.37 -8.17 -0.41 6.65e-15 Intelligence (multi-trait analysis); LUSC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg07414643 chr4:187882934 NA 0.55 10.53 0.5 1.41e-22 Lobe attachment (rater-scored or self-reported); LUSC cis rs708547 0.874 rs1630798 chr4:57883558 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.51 -6.63 -0.34 1.39e-10 Response to bleomycin (chromatid breaks); LUSC cis rs11098499 0.954 rs3733519 chr4:120423448 A/G cg09307838 chr4:120376055 NA 0.78 11.53 0.53 4.06e-26 Corneal astigmatism; LUSC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg12288994 chr5:1860383 NA 0.31 7.02 0.36 1.27e-11 Cardiovascular disease risk factors; LUSC cis rs1577917 0.958 rs10944168 chr6:86680156 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.47 -6.87 -0.35 3.13e-11 Response to antipsychotic treatment; LUSC trans rs61931739 0.534 rs2220547 chr12:34106255 G/A cg26384229 chr12:38710491 ALG10B 0.7 10.96 0.51 4.28e-24 Morning vs. evening chronotype; LUSC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg22857025 chr5:266934 NA -1.16 -16.62 -0.67 1.22e-45 Breast cancer; LUSC trans rs7824557 0.843 rs2736375 chr8:11115749 C/T cg15556689 chr8:8085844 FLJ10661 -0.56 -8.84 -0.44 5.51e-17 Retinal vascular caliber; LUSC cis rs7267979 1.000 rs2387881 chr20:25378172 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.69 -0.34 9.49e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2708977 0.637 rs618454 chr2:97080093 C/G cg01950434 chr2:97203154 ARID5A -0.44 -6.26 -0.32 1.16e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs9611565 0.573 rs9306355 chr22:42111896 A/T cg03806693 chr22:41940476 POLR3H 0.87 12.97 0.58 2.02e-31 Vitiligo; LUSC cis rs1865760 0.865 rs9393677 chr6:25945815 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 7.1 0.36 7.6e-12 Height; LUSC cis rs8141529 0.719 rs5762825 chr22:29223642 A/G cg02153584 chr22:29168773 CCDC117 0.66 10.6 0.5 8e-23 Lymphocyte counts; LUSC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg15556689 chr8:8085844 FLJ10661 -0.67 -10.88 -0.51 8.4e-24 Mood instability; LUSC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg01579765 chr21:45077557 HSF2BP -0.53 -11.35 -0.53 1.83e-25 Mean corpuscular volume; LUSC cis rs9467773 1.000 rs9393731 chr6:26529374 C/T cg09904177 chr6:26538194 HMGN4 0.76 14.41 0.62 5.82e-37 Intelligence (multi-trait analysis); LUSC trans rs10851478 0.872 rs12591659 chr15:49933823 G/A cg23074453 chr15:44487924 FRMD5 -0.33 -6.08 -0.32 3.26e-9 Oral cavity cancer; LUSC cis rs7572644 0.723 rs10201105 chr2:28131233 G/C cg27432699 chr2:27873401 GPN1 -0.52 -6.49 -0.33 3.05e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs61931739 0.534 rs10844725 chr12:34009504 C/A cg06521331 chr12:34319734 NA -0.48 -7.67 -0.39 1.84e-13 Morning vs. evening chronotype; LUSC cis rs68170813 0.559 rs1018946 chr7:106851754 T/C cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs73198271 0.653 rs10099808 chr8:8659873 A/G cg01851573 chr8:8652454 MFHAS1 -0.5 -8.58 -0.43 3.53e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2777491 0.957 rs7163788 chr15:41704789 A/G cg18705301 chr15:41695430 NDUFAF1 -0.73 -14.05 -0.61 1.55e-35 Ulcerative colitis; LUSC cis rs4604732 0.642 rs10925048 chr1:247640736 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.36 5.93 0.31 7.62e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg12843872 chr7:90894352 FZD1 0.45 6.33 0.33 7.86e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.4 0.38 1.15e-12 Schizophrenia; LUSC cis rs7607369 0.618 rs62193298 chr2:219655211 T/G cg02176678 chr2:219576539 TTLL4 -0.66 -12.89 -0.58 4.08e-31 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs2932538 0.922 rs12137107 chr1:113127437 A/G cg22162597 chr1:113214053 CAPZA1 0.7 10.1 0.48 4.1e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.85 -0.54 2.91e-27 Chronic sinus infection; LUSC cis rs1107366 0.722 rs35331719 chr3:125907392 C/A cg01346077 chr3:125931526 NA 0.34 6.43 0.33 4.32e-10 Metabolite levels; LUSC cis rs7904985 0.889 rs1078789 chr10:88110247 C/T cg07322936 chr10:88137208 NA -0.53 -7.14 -0.36 5.69e-12 Barrett's esophagus; LUSC cis rs1030268 0.651 rs12707121 chr7:133496379 A/G cg10665199 chr7:133106180 EXOC4 0.54 5.84 0.3 1.22e-8 Intelligence (multi-trait analysis); LUSC cis rs9660992 0.539 rs113699533 chr1:205122895 G/A cg03948781 chr1:205179583 DSTYK 0.32 6.21 0.32 1.53e-9 Mean corpuscular volume;Mean platelet volume; LUSC cis rs3857536 0.611 rs7748258 chr6:66932840 A/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.56e-10 Blood trace element (Cu levels); LUSC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg12311346 chr5:56204834 C5orf35 0.83 13.76 0.6 2e-34 Initial pursuit acceleration; LUSC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs35306767 0.953 rs12357633 chr10:957246 C/T cg10556349 chr10:835070 NA 0.56 6.44 0.33 4.08e-10 Eosinophil percentage of granulocytes; LUSC cis rs1371867 0.846 rs2919469 chr8:101233896 C/T cg06002616 chr8:101225028 SPAG1 -0.44 -7.23 -0.37 3.26e-12 Atrioventricular conduction; LUSC cis rs473651 0.740 rs502349 chr2:239318389 C/T cg21699342 chr2:239360505 ASB1 0.53 9.7 0.47 8.96e-20 Multiple system atrophy; LUSC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg22529645 chr1:3704559 LRRC47 0.38 6.77 0.35 5.86e-11 Red cell distribution width; LUSC cis rs4363385 0.643 rs11576457 chr1:152918556 C/T cg00922841 chr1:152955080 SPRR1A 0.41 6.88 0.35 2.99e-11 Inflammatory skin disease; LUSC cis rs6582630 0.638 rs10880620 chr12:38517467 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.65 -0.43 2.18e-16 Drug-induced liver injury (flucloxacillin); LUSC cis rs7582180 0.764 rs1946799 chr2:100921136 C/A cg08017756 chr2:100939284 LONRF2 -0.44 -8.21 -0.41 4.95e-15 Intelligence (multi-trait analysis); LUSC cis rs9457247 0.565 rs55873403 chr6:167511800 C/T cg07741184 chr6:167504864 NA 0.51 8.74 0.43 1.15e-16 Crohn's disease; LUSC cis rs68170813 0.559 rs17429118 chr7:106964052 C/T cg02696742 chr7:106810147 HBP1 -0.64 -9.47 -0.46 5.13e-19 Coronary artery disease; LUSC cis rs9905704 0.914 rs2643120 chr17:56826949 A/T cg12560992 chr17:57184187 TRIM37 0.56 7.89 0.4 4.39e-14 Testicular germ cell tumor; LUSC cis rs5758659 0.622 rs129856 chr22:42399396 C/G cg15557168 chr22:42548783 NA -0.33 -5.66 -0.3 3.18e-8 Cognitive function; LUSC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs9653442 0.628 rs12474386 chr2:100857017 G/A cg22139774 chr2:100720529 AFF3 -0.35 -5.88 -0.31 9.98e-9 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4243830 0.850 rs57203351 chr1:6601319 T/C cg05709478 chr1:6581295 PLEKHG5 0.51 5.99 0.31 5.54e-9 Body mass index; LUSC cis rs7267979 0.966 rs2145126 chr20:25263648 G/A cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.56e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg11075029 chr15:45492679 SHF 0.34 6.23 0.32 1.42e-9 Tuberculosis; LUSC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg05717871 chr11:638507 DRD4 -0.35 -6.08 -0.32 3.37e-9 Systemic lupus erythematosus; LUSC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg02873098 chr16:4524103 NMRAL1;HMOX2 0.46 6.75 0.35 6.72e-11 Schizophrenia; LUSC cis rs7707921 0.957 rs2059891 chr5:81508792 G/C cg15871215 chr5:81402204 ATG10 0.45 6.56 0.34 2.1e-10 Breast cancer; LUSC cis rs4780401 0.609 rs9923954 chr16:11816855 G/T cg01061890 chr16:11836724 TXNDC11 -0.56 -8.58 -0.42 3.71e-16 Rheumatoid arthritis; LUSC cis rs34779708 0.931 rs34954932 chr10:35410807 G/T cg04310649 chr10:35416472 CREM -0.41 -6.56 -0.34 2.02e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs8114671 0.562 rs2425005 chr20:33407715 C/G cg07148914 chr20:33460835 GGT7 -0.66 -7.7 -0.39 1.58e-13 Height; LUSC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg12292205 chr6:26970375 C6orf41 0.66 11.23 0.52 4.99e-25 Autism spectrum disorder or schizophrenia; LUSC cis rs6504663 0.558 rs11871603 chr17:48559037 T/G cg03611598 chr17:48586076 MYCBPAP 0.51 6.42 0.33 4.6e-10 Visceral fat; LUSC cis rs10782582 0.609 rs1630302 chr1:76412090 A/T cg10523679 chr1:76189770 ACADM -0.45 -6.63 -0.34 1.36e-10 Daytime sleep phenotypes; LUSC cis rs360798 0.512 rs9973612 chr2:63019815 G/C cg17519650 chr2:63277830 OTX1 -0.47 -6.54 -0.34 2.32e-10 Coronary artery disease; LUSC cis rs1997103 0.798 rs12154964 chr7:55414041 G/A cg17469321 chr7:55412551 NA 0.66 10.64 0.5 6.02e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7829975 0.509 rs7838674 chr8:8797073 A/T cg15556689 chr8:8085844 FLJ10661 -0.6 -9.94 -0.48 1.47e-20 Mood instability; LUSC cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg00530320 chr1:46809349 NSUN4 0.57 8.81 0.43 6.79e-17 Menopause (age at onset); LUSC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg06481639 chr22:41940642 POLR3H 0.49 5.67 0.3 3.04e-8 Vitiligo; LUSC trans rs7178375 1.000 rs4779797 chr15:31208425 C/T cg04373760 chr16:53404718 NA -0.63 -8.77 -0.43 9.19e-17 Hypertriglyceridemia; LUSC cis rs34115320 1 rs34115320 chr7:148783936 CT/C cg23158103 chr7:148848205 ZNF398 -0.4 -6.29 -0.33 9.97e-10 Sum basophil neutrophil counts;Neutrophil count; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg08544746 chr1:3713043 LRRC47 -0.49 -6.03 -0.31 4.38e-9 Neuroticism; LUSC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg11812906 chr14:75593930 NEK9 -0.63 -10.52 -0.5 1.56e-22 Height; LUSC cis rs7223966 0.961 rs17631394 chr17:61646000 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.42 -5.69 -0.3 2.73e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.4 -0.33 5.11e-10 Major depressive disorder; LUSC cis rs798554 0.616 rs1636252 chr7:2884993 A/C cg02423579 chr7:2872169 GNA12 -0.36 -5.77 -0.3 1.84e-8 Height; LUSC cis rs1018836 0.923 rs4734269 chr8:91635474 G/C cg16814680 chr8:91681699 NA -0.76 -12.42 -0.56 2.31e-29 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1577917 0.839 rs1447159 chr6:86609249 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -6.25 -0.32 1.22e-9 Response to antipsychotic treatment; LUSC cis rs7119038 0.774 rs73005423 chr11:118681079 A/G cg19308663 chr11:118741387 NA 0.36 6.35 0.33 7.15e-10 Sjögren's syndrome; LUSC cis rs12592111 1 rs12592111 chr15:78767346 G/A cg18825076 chr15:78729989 IREB2 -0.42 -6.72 -0.35 7.89e-11 Parental longevity (combined parental age at death);Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs500891 0.645 rs1180191 chr6:83965006 C/T cg08257003 chr6:84140564 ME1 0.3 6.66 0.34 1.09e-10 Platelet-derived growth factor BB levels; LUSC cis rs9326248 0.539 rs518181 chr11:116772787 C/A cg20608306 chr11:116969690 SIK3 0.37 6.78 0.35 5.47e-11 Blood protein levels; LUSC cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6547741 1.000 rs6750943 chr2:27777904 T/G cg12559939 chr2:27858050 GPN1 0.41 6.4 0.33 5.27e-10 Oral cavity cancer; LUSC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg25067162 chr17:41277974 BRCA1;NBR2 -0.36 -5.87 -0.31 1.05e-8 Menopause (age at onset); LUSC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11890956 chr21:40555474 PSMG1 -0.68 -9.75 -0.47 6.5e-20 Menarche (age at onset); LUSC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg13390004 chr1:15929781 NA 0.41 6.84 0.35 3.85e-11 Systolic blood pressure; LUSC cis rs9902453 0.933 rs1128156 chr17:28513176 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.65 0.43 2.28e-16 Coffee consumption (cups per day); LUSC cis rs6542838 0.641 rs883773 chr2:99491635 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.48 -6.39 -0.33 5.73e-10 Fear of minor pain; LUSC cis rs7527798 0.592 rs2296159 chr1:207851760 G/A cg09232269 chr1:207846808 CR1L -0.29 -6.26 -0.32 1.21e-9 Erythrocyte sedimentation rate; LUSC cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg12432903 chr7:1882776 MAD1L1 -0.49 -6.41 -0.33 4.89e-10 Bipolar disorder; LUSC cis rs921665 0.748 rs1869419 chr2:3202080 C/T cg02624386 chr2:3182749 NA 0.62 6.61 0.34 1.55e-10 World class endurance athleticism; LUSC cis rs4343996 0.536 rs1554497 chr7:3415446 G/T cg21248987 chr7:3385318 SDK1 -0.36 -6.14 -0.32 2.31e-9 Motion sickness; LUSC cis rs9486715 0.659 rs9399930 chr6:96854444 G/T cg06623918 chr6:96969491 KIAA0776 0.84 13.39 0.59 5.1e-33 Headache; LUSC trans rs208520 0.690 rs866452 chr6:66849936 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.1 -16.94 -0.68 6.53e-47 Exhaled nitric oxide output; LUSC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg06627628 chr2:24431161 ITSN2 -0.6 -7.27 -0.37 2.63e-12 Lymphocyte counts; LUSC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.77 0.3 1.8e-8 Lung cancer; LUSC cis rs10504073 0.647 rs10435612 chr8:49993696 A/T cg00325661 chr8:49890786 NA 0.62 9.93 0.48 1.51e-20 Blood metabolite ratios; LUSC cis rs5769707 0.935 rs739239 chr22:50050468 G/A cg08680598 chr22:49984980 NA -0.34 -6.32 -0.33 8.22e-10 Monocyte count;Monocyte percentage of white cells; LUSC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg14552801 chr7:65878734 NA -0.45 -6.48 -0.33 3.2e-10 Aortic root size; LUSC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg10755058 chr3:40428713 ENTPD3 0.37 5.99 0.31 5.42e-9 Renal cell carcinoma; LUSC cis rs2219968 1.000 rs13276048 chr8:78975258 G/A cg00738934 chr8:78996279 NA 0.35 6.23 0.32 1.37e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2304069 0.826 rs2244195 chr5:149403528 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.74 10.06 0.48 5.7e-21 HIV-1 control; LUSC trans rs853679 0.607 rs34396849 chr6:28250955 A/C cg01620082 chr3:125678407 NA -0.81 -7.79 -0.39 8.42e-14 Depression; LUSC cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg14993813 chr1:46806288 NSUN4 -0.52 -7.29 -0.37 2.2e-12 Menopause (age at onset); LUSC cis rs10493773 0.609 rs2389972 chr1:86190666 A/G cg17807903 chr1:86174739 ZNHIT6 -0.53 -14.57 -0.62 1.47e-37 Urate levels in overweight individuals; LUSC cis rs9905704 0.918 rs68139131 chr17:56717249 A/G cg12560992 chr17:57184187 TRIM37 0.55 7.85 0.39 5.74e-14 Testicular germ cell tumor; LUSC cis rs10979 1.000 rs9484769 chr6:143896719 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs4974559 0.739 rs6845586 chr4:1323070 G/A cg02980000 chr4:1222292 CTBP1 0.97 9.05 0.44 1.17e-17 Systolic blood pressure; LUSC trans rs1941687 0.764 rs1493918 chr18:31381845 C/G cg27147174 chr7:100797783 AP1S1 -0.53 -8.13 -0.41 8.21e-15 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg27129171 chr3:47204927 SETD2 -0.7 -11.39 -0.53 1.32e-25 Colorectal cancer; LUSC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg11645453 chr3:52864694 ITIH4 0.56 13.66 0.6 4.77e-34 Schizophrenia; LUSC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg25767906 chr1:53392781 SCP2 -0.48 -8.6 -0.43 3.13e-16 Monocyte count; LUSC cis rs9296092 0.560 rs9469511 chr6:33530930 T/G cg13560919 chr6:33536144 NA -0.86 -16.35 -0.67 1.43e-44 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs12760731 0.623 rs3791025 chr1:178357907 C/G cg00404053 chr1:178313656 RASAL2 0.47 5.69 0.3 2.73e-8 Obesity-related traits; LUSC cis rs2439831 0.850 rs2277531 chr15:44069069 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 8.8 0.43 7.49e-17 Lung cancer in ever smokers; LUSC cis rs3859192 0.561 rs12453343 chr17:38181176 C/A cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.69 0.57 2.12e-30 White blood cell count; LUSC cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg13010199 chr12:38710504 ALG10B 0.65 10.24 0.49 1.4e-21 Bladder cancer; LUSC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg03684893 chr10:554711 DIP2C -0.35 -6.35 -0.33 7.16e-10 Psychosis in Alzheimer's disease; LUSC cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg06064525 chr11:970664 AP2A2 -0.48 -10.38 -0.49 4.55e-22 Alzheimer's disease (late onset); LUSC trans rs6502050 0.835 rs3935129 chr17:80113381 G/C cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg25258033 chr6:167368657 RNASET2 -0.47 -7.95 -0.4 2.87e-14 Crohn's disease; LUSC trans rs11098499 0.863 rs7695620 chr4:120452776 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.49 6.72 0.35 8.08e-11 Corneal astigmatism; LUSC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg02423579 chr7:2872169 GNA12 -0.41 -6.38 -0.33 5.95e-10 Height; LUSC cis rs7180079 0.925 rs4776447 chr15:64643067 C/T cg02848875 chr15:64387786 SNX1 0.4 5.64 0.3 3.54e-8 Monocyte count; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg18758796 chr5:131593413 PDLIM4 0.35 6.27 0.32 1.1e-9 Blood metabolite levels; LUSC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg09835421 chr16:68378352 PRMT7 -0.55 -6.16 -0.32 2.09e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg12935359 chr14:103987150 CKB -0.52 -7.95 -0.4 2.93e-14 Body mass index; LUSC cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.53 7.89 0.4 4.39e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs9300255 0.602 rs2695478 chr12:123689521 C/T cg00376283 chr12:123451042 ABCB9 0.7 7.92 0.4 3.67e-14 Neutrophil percentage of white cells; LUSC cis rs6076065 0.723 rs6083088 chr20:23343793 G/T cg11657817 chr20:23433608 CST11 0.44 8.23 0.41 4.26e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg22535103 chr8:58192502 C8orf71 -0.68 -7.57 -0.38 3.62e-13 Developmental language disorder (linguistic errors); LUSC cis rs9815354 0.767 rs12185934 chr3:41836558 A/C cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs11098499 0.954 rs7656252 chr4:120404268 T/C cg24375607 chr4:120327624 NA 0.79 11.91 0.55 1.72e-27 Corneal astigmatism; LUSC cis rs1595825 0.735 rs6752760 chr2:198918164 G/T cg00982548 chr2:198649783 BOLL -0.54 -6.62 -0.34 1.43e-10 Ulcerative colitis; LUSC cis rs2637266 1.000 rs2637264 chr10:78322794 A/C cg18941641 chr10:78392320 NA 0.37 6.68 0.34 9.86e-11 Pulmonary function; LUSC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg22920501 chr2:26401640 FAM59B 0.73 9.91 0.48 1.81e-20 Gut microbiome composition (summer); LUSC cis rs17125944 0.686 rs912861 chr14:53333290 C/G cg00686598 chr14:53173677 PSMC6 -0.59 -5.7 -0.3 2.57e-8 Alzheimer's disease (late onset); LUSC cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg16339924 chr4:17578868 LAP3 0.49 7.41 0.38 1.02e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs113835537 0.529 rs2279865 chr11:66203025 A/C cg24851651 chr11:66362959 CCS 0.55 8.35 0.42 1.89e-15 Airway imaging phenotypes; LUSC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg13319975 chr6:146136371 FBXO30 -0.51 -7.66 -0.39 2.02e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6546550 0.901 rs4852375 chr2:70125988 C/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.37 -0.37 1.32e-12 Prevalent atrial fibrillation; LUSC cis rs6964587 1.000 rs2106171 chr7:91750450 A/G cg17063962 chr7:91808500 NA 0.6 9.45 0.46 6.13e-19 Breast cancer; LUSC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg18827107 chr12:86230957 RASSF9 -0.5 -7.48 -0.38 6.66e-13 Major depressive disorder; LUSC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg04450456 chr4:17643702 FAM184B 0.38 6.5 0.34 2.95e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2425143 1.000 rs10485510 chr20:34445164 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -6.09 -0.32 3.08e-9 Blood protein levels; LUSC cis rs4285028 0.948 rs34158925 chr3:121678465 C/A cg11130432 chr3:121712080 ILDR1 -0.63 -9.57 -0.46 2.41e-19 Multiple sclerosis; LUSC cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.73 -0.35 7.32e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 11.25 0.52 4.04e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg12698349 chr2:225449008 CUL3 -0.66 -8.58 -0.42 3.63e-16 IgE levels in asthmatics (D.p. specific); LUSC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg16680214 chr1:154839983 KCNN3 -0.51 -9.32 -0.45 1.67e-18 Prostate cancer; LUSC cis rs4654899 0.895 rs10916865 chr1:21136610 C/T cg01072550 chr1:21505969 NA 0.47 7.0 0.36 1.44e-11 Superior frontal gyrus grey matter volume; LUSC cis rs950776 0.518 rs12906284 chr15:78825105 C/T cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg00990874 chr7:1149470 C7orf50 -0.46 -5.8 -0.3 1.55e-8 Bronchopulmonary dysplasia; LUSC cis rs354225 0.544 rs10193692 chr2:54808340 A/T cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs7089973 0.624 rs10885614 chr10:116609098 C/T cg25233709 chr10:116636983 FAM160B1 0.37 6.55 0.34 2.13e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg27094323 chr7:1216898 NA -0.36 -6.12 -0.32 2.65e-9 Longevity;Endometriosis; LUSC cis rs472402 0.560 rs2288447 chr5:6626091 C/T cg07758902 chr5:6633253 NSUN2;SRD5A1 -0.5 -7.37 -0.37 1.39e-12 Response to amphetamines; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg16031515 chr1:205743344 RAB7L1 -0.27 -5.69 -0.3 2.8e-8 Menarche (age at onset); LUSC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -5.98 -0.31 5.61e-9 Tonsillectomy; LUSC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg06212747 chr3:49208901 KLHDC8B 0.44 6.06 0.31 3.64e-9 Parkinson's disease; LUSC cis rs710216 0.718 rs841852 chr1:43401499 C/T cg03128534 chr1:43423976 SLC2A1 0.46 5.82 0.3 1.42e-8 Red cell distribution width; LUSC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg10645314 chr2:3704589 ALLC -0.52 -7.77 -0.39 9.84e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg06697600 chr4:7070879 GRPEL1 -0.39 -6.7 -0.34 8.96e-11 Monocyte percentage of white cells; LUSC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg11812906 chr14:75593930 NEK9 0.39 5.71 0.3 2.53e-8 Caffeine consumption; LUSC cis rs3096299 0.702 rs2086825 chr16:89471542 C/T cg00750074 chr16:89608354 SPG7 -0.44 -7.64 -0.39 2.26e-13 Multiple myeloma (IgH translocation); LUSC cis rs9814567 0.762 rs13093893 chr3:134292131 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.85 11.92 0.55 1.51e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs6600671 0.934 rs11249348 chr1:121188302 T/C cg08727972 chr1:148025634 NBPF14 0.45 6.36 0.33 6.49e-10 Hip geometry; LUSC cis rs2070488 0.775 rs1073506 chr3:38566235 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.63 -10.84 -0.51 1.16e-23 Electrocardiographic conduction measures; LUSC cis rs2730245 0.527 rs842695 chr7:158662182 G/A cg11984989 chr7:158649758 WDR60 1.12 13.99 0.61 2.61e-35 Height; LUSC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg25039879 chr17:56429692 SUPT4H1 0.72 9.82 0.47 3.63e-20 Cognitive test performance; LUSC cis rs5758511 0.773 rs9623482 chr22:42360574 T/C cg00645731 chr22:42541494 CYP2D7P1 0.45 7.35 0.37 1.55e-12 Birth weight; LUSC cis rs9326248 0.911 rs11216284 chr11:117003060 C/T cg11861562 chr11:117069780 TAGLN 0.44 7.74 0.39 1.21e-13 Blood protein levels; LUSC cis rs7769051 1.000 rs9493443 chr6:133121349 C/T cg22852734 chr6:133119734 C6orf192 1.17 14.03 0.61 1.8e-35 Type 2 diabetes nephropathy; LUSC cis rs12760731 0.668 rs73037529 chr1:178410203 A/T cg00404053 chr1:178313656 RASAL2 0.59 6.22 0.32 1.46e-9 Obesity-related traits; LUSC cis rs4704187 0.687 rs9654426 chr5:74466737 C/T cg03227963 chr5:74354835 NA 0.3 6.59 0.34 1.68e-10 Response to amphetamines; LUSC trans rs7944735 0.817 rs747782 chr11:47940925 A/G cg03929089 chr4:120376271 NA 0.56 6.03 0.31 4.3e-9 Intraocular pressure; LUSC cis rs7804356 1.000 rs12532199 chr7:26854375 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg26587870 chr6:27730563 NA 0.65 6.09 0.32 3.12e-9 Depression; LUSC cis rs34330 0.562 rs10492235 chr12:12851339 T/G cg09462578 chr12:12878428 APOLD1 -0.68 -7.89 -0.4 4.41e-14 Systemic lupus erythematosus; LUSC cis rs7589342 0.831 rs13429270 chr2:106453060 C/T cg16077055 chr2:106428750 NCK2 0.37 6.96 0.36 1.76e-11 Addiction; LUSC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.81 0.54 3.94e-27 Prudent dietary pattern; LUSC trans rs208520 0.770 rs2224422 chr6:66883993 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -15.15 -0.64 7.76e-40 Exhaled nitric oxide output; LUSC cis rs4820294 0.669 rs9622677 chr22:38054262 A/C cg21798802 chr22:38057573 PDXP 0.32 6.57 0.34 1.89e-10 Fat distribution (HIV); LUSC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg11764359 chr7:65958608 NA 0.52 6.85 0.35 3.5e-11 Aortic root size; LUSC trans rs7824557 0.767 rs17797443 chr8:11164012 T/C cg08975724 chr8:8085496 FLJ10661 0.46 6.71 0.34 8.31e-11 Retinal vascular caliber; LUSC cis rs4555082 0.957 rs10140586 chr14:105749582 A/G cg13114125 chr14:105738426 BRF1 -0.9 -14.91 -0.63 7.09e-39 Mean platelet volume;Platelet distribution width; LUSC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg00484396 chr16:3507460 NAT15 0.92 10.5 0.5 1.72e-22 Tuberculosis; LUSC cis rs9314323 0.693 rs13264882 chr8:26224240 G/T cg11498726 chr8:26250323 BNIP3L -0.43 -6.2 -0.32 1.7e-9 Red cell distribution width; LUSC cis rs7091068 0.616 rs7920366 chr10:95497178 A/T cg20715218 chr10:95462985 C10orf4 0.62 6.66 0.34 1.12e-10 Urinary tract infection frequency; LUSC cis rs6977660 0.660 rs12531278 chr7:19816439 A/T cg07541023 chr7:19748670 TWISTNB 0.63 6.84 0.35 3.87e-11 Thyroid stimulating hormone; LUSC cis rs67460515 0.528 rs11915989 chr3:160902259 A/G cg03342759 chr3:160939853 NMD3 -0.43 -6.18 -0.32 1.86e-9 Parkinson's disease; LUSC cis rs40363 1.000 rs1690443 chr16:3517787 C/G cg21433313 chr16:3507492 NAT15 0.8 10.09 0.48 4.62e-21 Tuberculosis; LUSC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg05425664 chr17:57184151 TRIM37 0.54 7.95 0.4 2.95e-14 Intelligence (multi-trait analysis); LUSC cis rs2439831 0.850 rs28684672 chr15:44107662 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.93 9.16 0.45 5.22e-18 Lung cancer in ever smokers; LUSC cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -8.15 -0.41 7.3e-15 Chronic sinus infection; LUSC cis rs6951245 0.572 rs75083636 chr7:1050800 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -6.38 -0.33 5.89e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs2197308 0.594 rs9705810 chr12:37895003 G/A cg06521331 chr12:34319734 NA 0.4 6.22 0.32 1.48e-9 Morning vs. evening chronotype; LUSC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg11764359 chr7:65958608 NA -0.79 -13.11 -0.58 5.7e-32 Aortic root size; LUSC cis rs9560113 0.550 rs1163632 chr13:112231530 T/C cg10483660 chr13:112241077 NA -0.39 -7.2 -0.37 4.13e-12 Menarche (age at onset); LUSC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.29 0.33 1.01e-9 Menopause (age at onset); LUSC cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg15744005 chr10:104629667 AS3MT -0.32 -6.74 -0.35 7.16e-11 Arsenic metabolism; LUSC cis rs9309473 0.500 rs11126402 chr2:73776582 G/C cg20560298 chr2:73613845 ALMS1 -0.43 -6.64 -0.34 1.26e-10 Metabolite levels; LUSC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg06008330 chr7:65541103 ASL 0.39 6.15 0.32 2.17e-9 Aortic root size; LUSC cis rs11630290 0.589 rs925250 chr15:64175099 C/A cg12036633 chr15:63758958 NA -0.51 -6.45 -0.33 4.03e-10 Iris characteristics; LUSC trans rs9944715 0.954 rs12457740 chr18:43741742 G/A cg01718231 chr17:29326311 RNF135 0.48 6.82 0.35 4.35e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs290268 1.000 rs290268 chr9:93552450 A/G cg02608019 chr9:93564028 SYK 0.55 9.13 0.45 6.57e-18 Platelet count; LUSC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg00945038 chr17:61921165 SMARCD2 0.37 5.66 0.3 3.21e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs6012953 0.874 rs734589 chr20:49178921 G/A cg13958625 chr20:49123093 NA -0.26 -5.76 -0.3 1.91e-8 Vitiligo; LUSC cis rs67072384 0.818 rs12287481 chr11:72472336 A/C cg04827223 chr11:72435913 ARAP1 0.78 6.63 0.34 1.35e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs3540 0.553 rs8042861 chr15:90977333 G/T cg22089800 chr15:90895588 ZNF774 0.63 10.3 0.49 8.81e-22 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 3.03e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs5758511 0.689 rs45441993 chr22:42471738 C/A cg12850546 chr22:42539477 CYP2D7P1 -0.69 -7.52 -0.38 5.12e-13 Birth weight; LUSC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg06618935 chr21:46677482 NA -0.39 -7.74 -0.39 1.18e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg18099408 chr3:52552593 STAB1 0.4 6.96 0.36 1.79e-11 Bipolar disorder; LUSC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -12.01 -0.55 7.21e-28 Extrinsic epigenetic age acceleration; LUSC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11644478 chr21:40555479 PSMG1 0.9 16.45 0.67 5.98e-45 Cognitive function; LUSC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg12379764 chr21:47803548 PCNT -0.61 -8.2 -0.41 5.34e-15 Testicular germ cell tumor; LUSC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg12257692 chr3:49977190 RBM6 -0.25 -6.88 -0.35 2.9e-11 Intelligence (multi-trait analysis); LUSC cis rs754466 1.000 rs67059283 chr10:79683235 C/T cg17075019 chr10:79541650 NA -0.64 -8.45 -0.42 9.28e-16 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.19 16.27 0.66 3.11e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.24 30.46 0.86 1.98e-98 Chronic sinus infection; LUSC cis rs7191439 0.790 rs2306046 chr16:88781419 A/G cg27087555 chr16:88793112 FAM38A -1.38 -13.78 -0.6 1.66e-34 Plateletcrit; LUSC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg11366901 chr6:160182831 ACAT2 -0.85 -11.48 -0.53 5.96e-26 Age-related macular degeneration (geographic atrophy); LUSC cis rs9443189 0.570 rs72884926 chr6:76266208 T/C cg01950844 chr6:76311363 SENP6 0.68 6.96 0.36 1.76e-11 Prostate cancer; LUSC cis rs7527798 0.592 rs11118278 chr1:207831357 C/G cg09232269 chr1:207846808 CR1L -0.31 -6.32 -0.33 8.26e-10 Erythrocyte sedimentation rate; LUSC cis rs6545883 0.794 rs778152 chr2:61608540 C/A cg15711740 chr2:61764176 XPO1 0.41 6.42 0.33 4.57e-10 Tuberculosis; LUSC cis rs6964587 1.000 rs2285333 chr7:91667692 T/G cg01689657 chr7:91764605 CYP51A1 0.32 5.81 0.3 1.44e-8 Breast cancer; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.67 0.57 2.55e-30 Prudent dietary pattern; LUSC cis rs9372253 1.000 rs9374170 chr6:110712991 A/G cg19196401 chr6:110721138 DDO -0.42 -7.75 -0.39 1.12e-13 Platelet distribution width; LUSC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12667521 chr19:29218732 NA 0.63 9.05 0.44 1.24e-17 Methadone dose in opioid dependence; LUSC cis rs847577 0.609 rs17435847 chr7:97792820 G/A cg24562669 chr7:97807699 LMTK2 0.48 8.64 0.43 2.3e-16 Breast cancer; LUSC cis rs2075671 0.903 rs10953300 chr7:100263784 C/G cg00334542 chr7:100209784 MOSPD3 -0.49 -5.74 -0.3 2.11e-8 Other erythrocyte phenotypes; LUSC cis rs68170813 0.559 rs3801958 chr7:106961139 C/T cg02696742 chr7:106810147 HBP1 -0.61 -9.07 -0.44 1.03e-17 Coronary artery disease; LUSC cis rs12908161 1.000 rs12905057 chr15:85210765 A/G cg17173187 chr15:85201210 NMB 0.49 9.08 0.44 9.81e-18 Schizophrenia; LUSC cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg04450456 chr4:17643702 FAM184B -0.4 -6.43 -0.33 4.45e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg18607491 chr14:51706792 TMX1 0.45 6.34 0.33 7.24e-10 Mosquito bite size; LUSC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.49 7.99 0.4 2.2e-14 Parkinson's disease; LUSC cis rs17401966 0.522 rs946504 chr1:10308597 T/C cg17425144 chr1:10567563 PEX14 -0.32 -5.79 -0.3 1.6e-8 Hepatocellular carcinoma; LUSC cis rs752092 1.000 rs11636578 chr15:101787969 T/C cg19997662 chr15:101784653 CHSY1 -0.43 -6.06 -0.31 3.75e-9 Corneal structure; LUSC trans rs853679 0.556 rs45509595 chr6:27840926 T/C cg06606381 chr12:133084897 FBRSL1 -1.03 -8.93 -0.44 2.97e-17 Depression; LUSC cis rs2976388 0.669 rs2585135 chr8:143814193 A/G cg17252645 chr8:143867129 LY6D -0.38 -6.73 -0.35 7.45e-11 Urinary tract infection frequency; LUSC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg13175981 chr1:150552382 MCL1 -0.41 -5.68 -0.3 2.92e-8 Tonsillectomy; LUSC cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg26384229 chr12:38710491 ALG10B 0.87 16.75 0.68 3.68e-46 Heart rate; LUSC cis rs7909074 0.966 rs4268464 chr10:45401081 T/A cg04218760 chr10:45406644 TMEM72 -0.29 -6.91 -0.35 2.53e-11 Mean corpuscular volume; LUSC trans rs12310956 0.515 rs1872745 chr12:33985987 G/A cg13010199 chr12:38710504 ALG10B 0.52 7.72 0.39 1.34e-13 Morning vs. evening chronotype; LUSC cis rs2354432 0.546 rs11240030 chr1:146882616 G/A cg25205988 chr1:146714368 CHD1L 0.94 9.13 0.45 6.65e-18 Mitochondrial DNA levels; LUSC cis rs1371867 0.839 rs1660313 chr8:101332712 G/A cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg23985595 chr17:80112537 CCDC57 -0.3 -5.71 -0.3 2.52e-8 Life satisfaction; LUSC cis rs6061231 0.755 rs11699160 chr20:60958651 T/C cg24112000 chr20:60950667 NA -0.42 -8.23 -0.41 4.32e-15 Colorectal cancer; LUSC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg05313129 chr8:58192883 C8orf71 -0.49 -6.45 -0.33 3.9e-10 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 10.15 0.49 2.78e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg03929089 chr4:120376271 NA -1.03 -19.84 -0.74 2.02e-58 Height; LUSC cis rs734999 0.588 rs6701238 chr1:2520500 G/A cg18932078 chr1:2524107 MMEL1 0.3 6.61 0.34 1.55e-10 Ulcerative colitis; LUSC cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg15423357 chr2:25149977 NA 0.45 9.12 0.45 7e-18 Body mass index; LUSC cis rs7180079 1.000 rs62021592 chr15:64522368 T/G cg08069370 chr15:64387884 SNX1 -0.54 -5.85 -0.3 1.17e-8 Monocyte count; LUSC cis rs7917772 0.545 rs10786681 chr10:104317357 G/T cg05855489 chr10:104503620 C10orf26 -0.49 -7.46 -0.38 7.74e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg03709012 chr19:19516395 GATAD2A 0.87 14.72 0.63 3.76e-38 Tonsillectomy; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.58 -0.38 3.42e-13 Lymphocyte counts; LUSC cis rs950881 0.932 rs10189526 chr2:102937883 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.37 0.33 6.4e-10 Allergy; LUSC cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg05472934 chr7:22766657 IL6 0.39 6.04 0.31 4.16e-9 Lung cancer; LUSC cis rs7605827 0.704 rs3732001 chr2:15536872 T/C cg19274914 chr2:15703543 NA 0.46 9.03 0.44 1.45e-17 Educational attainment (years of education); LUSC cis rs12458462 0.892 rs2242174 chr18:77458037 T/C cg20476159 chr18:77451067 CTDP1 -0.31 -5.65 -0.3 3.41e-8 Monocyte count; LUSC cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg16586182 chr3:47516702 SCAP -0.5 -7.88 -0.4 4.72e-14 Colorectal cancer; LUSC trans rs2197308 0.605 rs2387437 chr12:37919367 T/C cg06521331 chr12:34319734 NA -0.41 -6.48 -0.33 3.26e-10 Morning vs. evening chronotype; LUSC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg20406979 chr6:167373233 NA 0.26 6.21 0.32 1.6e-9 Crohn's disease; LUSC cis rs4494114 1.000 rs4589074 chr1:39354508 T/G cg25970120 chr1:39325951 RRAGC -0.4 -6.19 -0.32 1.8e-9 Blood protein levels; LUSC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.19 -0.37 4.24e-12 Alzheimer's disease (late onset); LUSC cis rs2274273 0.840 rs11626751 chr14:55835227 T/C cg04306507 chr14:55594613 LGALS3 0.54 11.89 0.55 2.08e-27 Protein biomarker; LUSC cis rs372883 0.648 rs1003772 chr21:30736145 A/T cg24692254 chr21:30365293 RNF160 0.74 11.67 0.54 1.32e-26 Pancreatic cancer; LUSC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg04518342 chr5:131593106 PDLIM4 -0.43 -6.92 -0.35 2.3e-11 Breast cancer; LUSC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.69 -10.78 -0.51 1.94e-23 Menarche (age at onset); LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs4704187 0.687 rs2112871 chr5:74469853 G/A cg03227963 chr5:74354835 NA 0.29 6.22 0.32 1.46e-9 Response to amphetamines; LUSC cis rs9467711 0.606 rs9358935 chr6:26369587 A/G cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs11711311 0.911 rs3773681 chr3:113523901 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.5 6.89 0.35 2.84e-11 IgG glycosylation; LUSC cis rs34779708 0.897 rs34481177 chr10:35380913 C/T cg04310649 chr10:35416472 CREM -0.43 -6.6 -0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9837602 0.938 rs9828079 chr3:99806645 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.51 6.28 0.32 1.08e-9 Breast cancer; LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17102423 0.826 rs10873180 chr14:65604361 A/G cg11161011 chr14:65562177 MAX 0.71 11.12 0.52 1.23e-24 Obesity-related traits; LUSC cis rs611744 0.647 rs10106246 chr8:109268710 T/C cg18478394 chr8:109455254 TTC35 0.42 6.6 0.34 1.6e-10 Dupuytren's disease; LUSC cis rs7100689 0.784 rs4934153 chr10:82191255 T/C cg00277334 chr10:82204260 NA -0.56 -7.66 -0.39 2.09e-13 Post bronchodilator FEV1; LUSC cis rs12908161 1.000 rs34900908 chr15:85257599 G/A cg17507749 chr15:85114479 UBE2QP1 0.56 6.91 0.35 2.45e-11 Schizophrenia; LUSC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -11.86 -0.54 2.59e-27 Extrinsic epigenetic age acceleration; LUSC cis rs2742234 0.590 rs2503848 chr10:43672785 G/A cg15436174 chr10:43711423 RASGEF1A -0.43 -7.03 -0.36 1.17e-11 Hirschsprung disease; LUSC cis rs12618769 0.681 rs72823792 chr2:99215142 G/A cg10123293 chr2:99228465 UNC50 0.47 7.6 0.38 2.98e-13 Bipolar disorder; LUSC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg08499158 chr17:42289980 UBTF -0.52 -8.72 -0.43 1.3e-16 Total body bone mineral density; LUSC cis rs11190604 1.000 rs10883510 chr10:102297018 C/T cg16342193 chr10:102329863 NA -0.39 -6.81 -0.35 4.54e-11 Palmitoleic acid (16:1n-7) levels; LUSC trans rs877282 0.898 rs11253346 chr10:765313 A/G cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs951366 0.538 rs56276813 chr1:205730573 G/T cg11965913 chr1:205819406 PM20D1 -0.48 -6.63 -0.34 1.34e-10 Menarche (age at onset); LUSC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg04450456 chr4:17643702 FAM184B -0.42 -6.85 -0.35 3.56e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg08680598 chr22:49984980 NA -0.32 -5.92 -0.31 8.11e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg08677398 chr8:58056175 NA 0.53 7.01 0.36 1.33e-11 Developmental language disorder (linguistic errors); LUSC cis rs10419226 0.533 rs6510996 chr19:18788208 A/G cg22001208 chr19:18782374 NA -0.37 -6.07 -0.32 3.54e-9 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg23158103 chr7:148848205 ZNF398 -0.48 -7.91 -0.4 3.75e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg09877947 chr5:131593287 PDLIM4 0.55 9.03 0.44 1.37e-17 Acylcarnitine levels; LUSC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.62 6.04 0.31 4.07e-9 Cerebrospinal P-tau181p levels; LUSC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg12463550 chr7:65579703 CRCP 0.51 7.4 0.38 1.13e-12 Aortic root size; LUSC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg08470875 chr2:26401718 FAM59B -0.65 -8.64 -0.43 2.33e-16 Gut microbiome composition (summer); LUSC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 14.23 0.61 2.95e-36 Platelet count; LUSC cis rs250677 0.652 rs250675 chr5:148438565 A/C cg18129178 chr5:148520854 ABLIM3 0.56 8.28 0.41 2.97e-15 Breast cancer; LUSC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg09835421 chr16:68378352 PRMT7 -0.55 -6.16 -0.32 2.09e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg00908189 chr16:619842 PIGQ 0.72 11.64 0.54 1.62e-26 Height; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg07902188 chr19:30097207 POP4 0.78 6.19 0.32 1.76e-9 Cognitive performance; LUSC cis rs2011503 1.000 rs2011503 chr19:19443986 C/T cg15839431 chr19:19639596 YJEFN3 -0.56 -6.16 -0.32 2.03e-9 Bipolar disorder; LUSC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg20476274 chr7:133979776 SLC35B4 0.88 16.95 0.68 6.26e-47 Mean platelet volume; LUSC cis rs10489525 0.528 rs360604 chr1:115390019 G/A cg12756093 chr1:115239321 AMPD1 0.52 7.01 0.36 1.34e-11 Autism; LUSC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg05368731 chr17:41323189 NBR1 0.74 12.41 0.56 2.42e-29 Menopause (age at onset); LUSC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.08 15.39 0.64 8.93e-41 Gut microbiome composition (summer); LUSC cis rs8017423 0.647 rs12883357 chr14:90815032 A/G cg04374321 chr14:90722782 PSMC1 -0.49 -7.48 -0.38 6.74e-13 Mortality in heart failure; LUSC cis rs10751667 0.621 rs4075990 chr11:976614 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.3e-10 Alzheimer's disease (late onset); LUSC cis rs524023 1.000 rs12786214 chr11:64364203 G/A cg07220939 chr11:64358617 SLC22A12 -0.22 -5.74 -0.3 2.16e-8 Urate levels in obese individuals; LUSC trans rs61931739 0.817 rs1705771 chr12:34174950 C/G cg13010199 chr12:38710504 ALG10B 0.42 6.66 0.34 1.1e-10 Morning vs. evening chronotype; LUSC cis rs6598955 0.627 rs7550127 chr1:26592871 C/T cg00852783 chr1:26633632 UBXN11 -0.48 -5.71 -0.3 2.56e-8 Obesity-related traits; LUSC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs9467711 0.790 rs1979 chr6:26377591 G/T cg09904177 chr6:26538194 HMGN4 -0.71 -6.76 -0.35 6.06e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs57590327 0.504 rs4856348 chr3:81502923 T/G cg07356753 chr3:81810745 GBE1 0.46 6.12 0.32 2.61e-9 Extraversion; LUSC cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.13 0.55 2.73e-28 Colorectal cancer; LUSC cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg07424592 chr7:64974309 NA 0.69 6.09 0.32 3.03e-9 Diabetic kidney disease; LUSC trans rs561341 1.000 rs501312 chr17:30329066 A/G cg20587970 chr11:113659929 NA -1.31 -18.31 -0.71 2.43e-52 Hip circumference adjusted for BMI; LUSC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg02807482 chr3:125708958 NA -0.52 -6.55 -0.34 2.23e-10 Blood pressure (smoking interaction); LUSC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.73 0.51 2.84e-23 Hip circumference adjusted for BMI; LUSC cis rs68170813 0.559 rs4730239 chr7:107056960 A/T cg02696742 chr7:106810147 HBP1 -0.65 -9.32 -0.45 1.62e-18 Coronary artery disease; LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg05896524 chr21:47604654 C21orf56 -0.53 -8.17 -0.41 6.37e-15 Testicular germ cell tumor; LUSC cis rs9303542 0.559 rs62066693 chr17:46617530 G/C cg09704116 chr17:46666958 LOC404266 -0.38 -6.69 -0.34 9.51e-11 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs4803468 1.000 rs284657 chr19:41929915 G/C cg09537434 chr19:41945824 ATP5SL -0.93 -15.94 -0.66 6.43e-43 Height; LUSC cis rs868036 0.681 rs4776976 chr15:68103291 C/T cg08079166 chr15:68083412 MAP2K5 0.41 7.23 0.37 3.29e-12 Restless legs syndrome; LUSC cis rs7000551 0.715 rs1600877 chr8:22378118 C/T cg12081754 chr8:22256438 SLC39A14 0.45 6.8 0.35 4.81e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs354225 0.544 rs13386146 chr2:54802514 G/C cg01766943 chr2:54829624 SPTBN1 0.48 7.75 0.39 1.11e-13 Schizophrenia; LUSC cis rs11048434 0.736 rs1805724 chr12:9104609 T/C cg13575925 chr12:9217583 LOC144571 0.35 6.41 0.33 4.82e-10 Sjögren's syndrome; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg00934312 chr7:149570931 ATP6V0E2;LOC401431 0.39 5.94 0.31 6.99e-9 Schizophrenia; LUSC trans rs208520 0.565 rs1385222 chr6:66753013 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.16 22.2 0.77 9.81e-68 Exhaled nitric oxide output; LUSC cis rs7605827 0.930 rs10203196 chr2:15541154 A/T cg19274914 chr2:15703543 NA 0.47 9.24 0.45 3.06e-18 Educational attainment (years of education); LUSC cis rs2282300 0.739 rs7942129 chr11:30224692 G/A cg25418670 chr11:30344373 C11orf46 -0.61 -8.81 -0.43 7.19e-17 Morning vs. evening chronotype; LUSC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg00677455 chr12:58241039 CTDSP2 0.61 8.58 0.42 3.64e-16 Multiple sclerosis; LUSC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC cis rs9300255 0.506 rs11057251 chr12:123791227 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.35 6.72 0.34 8.01e-11 Neutrophil percentage of white cells; LUSC cis rs7208859 0.623 rs73269945 chr17:29108759 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs9467773 1.000 rs6910899 chr6:26524339 A/G cg05738196 chr6:26577821 NA 0.81 15.71 0.65 4.89e-42 Intelligence (multi-trait analysis); LUSC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg16325326 chr1:53192061 ZYG11B 0.81 13.96 0.61 3.24e-35 Monocyte count; LUSC trans rs61931739 1.000 rs12427391 chr12:34022891 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.89 -0.4 4.31e-14 Morning vs. evening chronotype; LUSC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg11965913 chr1:205819406 PM20D1 -0.89 -18.14 -0.7 1.16e-51 Menarche (age at onset); LUSC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7267979 0.966 rs910996 chr20:25264196 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.88 20.01 0.74 4.35e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg23172400 chr8:95962367 TP53INP1 -0.43 -8.96 -0.44 2.27e-17 Type 2 diabetes; LUSC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg00409905 chr10:38381863 ZNF37A -0.38 -6.44 -0.33 4.21e-10 Extrinsic epigenetic age acceleration; LUSC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg07157834 chr1:205819609 PM20D1 0.85 15.33 0.64 1.61e-40 Menarche (age at onset); LUSC trans rs1922233 1.000 rs10013671 chr4:92379974 G/A cg24250684 chr1:219729030 NA -0.32 -5.99 -0.31 5.54e-9 Gut microbiome composition (summer and winter); LUSC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg22496380 chr5:211416 CCDC127 -0.7 -8.07 -0.4 1.24e-14 Breast cancer; LUSC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg11843238 chr5:131593191 PDLIM4 -0.4 -6.55 -0.34 2.18e-10 Blood metabolite levels; LUSC cis rs4776059 1.000 rs4776058 chr15:52880263 A/G cg22715398 chr15:52968154 KIAA1370 -0.73 -10.48 -0.5 2.05e-22 Schizophrenia; LUSC cis rs2840044 1.000 rs9913003 chr17:33893904 C/A cg05299278 chr17:33885742 SLFN14 -0.31 -6.34 -0.33 7.35e-10 Response to radiotherapy in cancer (late toxicity); LUSC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg26668828 chr6:292823 DUSP22 0.75 12.66 0.57 2.8e-30 Menopause (age at onset); LUSC cis rs2046867 0.908 rs1106310 chr3:72818902 A/T cg25664220 chr3:72788482 NA 0.62 11.12 0.52 1.17e-24 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg22903471 chr2:27725779 GCKR -0.37 -6.41 -0.33 4.92e-10 Total body bone mineral density; LUSC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg02423579 chr7:2872169 GNA12 -0.44 -6.16 -0.32 2.1e-9 Height; LUSC cis rs7224314 1.000 rs7219229 chr17:65380171 C/T cg01507342 chr17:65387096 PITPNC1 -0.44 -7.87 -0.4 4.95e-14 Diisocyanate-induced asthma; LUSC cis rs6489882 0.867 rs6489875 chr12:113368030 G/A cg20102336 chr12:113376681 OAS3 -0.4 -5.74 -0.3 2.17e-8 Chronic lymphocytic leukemia; LUSC cis rs2742234 0.541 rs11528481 chr10:43737767 C/A cg07801480 chr10:43725741 RASGEF1A -0.4 -5.88 -0.31 9.77e-9 Hirschsprung disease; LUSC cis rs6987853 0.966 rs2974342 chr8:42436651 A/C cg09913449 chr8:42400586 C8orf40 0.49 8.35 0.42 1.89e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC cis rs6977660 0.714 rs12666488 chr7:19788403 G/A cg05791153 chr7:19748676 TWISTNB 0.77 8.32 0.41 2.19e-15 Thyroid stimulating hormone; LUSC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg04267008 chr7:1944627 MAD1L1 -0.52 -7.53 -0.38 4.69e-13 Schizophrenia; LUSC cis rs35883536 0.588 rs72977389 chr1:101107053 A/C cg06223162 chr1:101003688 GPR88 0.35 6.2 0.32 1.68e-9 Monocyte count; LUSC cis rs9300255 0.602 rs1716160 chr12:123700225 C/T cg00376283 chr12:123451042 ABCB9 0.64 8.17 0.41 6.39e-15 Neutrophil percentage of white cells; LUSC cis rs1670533 1.000 rs11731320 chr4:1057916 T/A cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC trans rs208520 0.874 rs208518 chr6:66948501 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 13.55 0.6 1.27e-33 Exhaled nitric oxide output; LUSC cis rs9486719 1.000 rs12210146 chr6:96903962 A/G cg06623918 chr6:96969491 KIAA0776 0.79 9.69 0.47 9.96e-20 Migraine;Coronary artery disease; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg22166914 chr1:53195759 ZYG11B -0.41 -6.02 -0.31 4.49e-9 Monocyte count; LUSC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg05623727 chr3:50126028 RBM5 -0.33 -6.11 -0.32 2.72e-9 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg11062466 chr8:58055876 NA 0.65 8.57 0.42 4.03e-16 Developmental language disorder (linguistic errors); LUSC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.08 0.32 3.3e-9 Mean platelet volume; LUSC cis rs7589342 0.831 rs10169998 chr2:106452253 A/G cg16077055 chr2:106428750 NCK2 0.37 7.04 0.36 1.12e-11 Addiction; LUSC trans rs6502050 0.835 rs62080004 chr17:80079079 C/T cg07393940 chr7:158741817 NA -0.37 -6.6 -0.34 1.61e-10 Life satisfaction; LUSC cis rs4499344 0.730 rs2903755 chr19:33098870 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg25182066 chr10:30743637 MAP3K8 -0.42 -6.15 -0.32 2.19e-9 Inflammatory bowel disease; LUSC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs1577917 0.771 rs9362233 chr6:86358247 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.78 -0.43 8.73e-17 Response to antipsychotic treatment; LUSC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg04362960 chr10:104952993 NT5C2 0.53 6.55 0.34 2.22e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs4665809 0.878 rs6720312 chr2:26364934 A/G cg24905901 chr12:53901029 NPFF 0.5 6.04 0.31 4.04e-9 Gut microbiome composition (summer); LUSC cis rs7119167 0.901 rs10898920 chr11:73140138 T/A cg17517138 chr11:73019481 ARHGEF17 0.52 5.91 0.31 8.53e-9 Blood protein levels; LUSC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.56 -0.34 2.03e-10 Lung cancer; LUSC cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg05294307 chr14:35346193 BAZ1A -0.6 -7.05 -0.36 1.06e-11 Psoriasis; LUSC cis rs1891275 0.515 rs7475294 chr10:93508199 T/C cg07889827 chr10:93443413 NA -0.4 -9.29 -0.45 2.06e-18 Intelligence (multi-trait analysis); LUSC cis rs9420 0.809 rs11600169 chr11:57464945 T/A cg23127183 chr11:57508653 C11orf31 -0.57 -8.86 -0.44 4.99e-17 Schizophrenia; LUSC cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.54 -0.42 4.85e-16 Body mass index; LUSC cis rs1881797 0.527 rs78398999 chr1:247686970 G/A cg14830002 chr1:247616686 OR2B11 0.65 7.35 0.37 1.49e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs9400467 0.528 rs456569 chr6:111674801 T/G cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg21881798 chr11:8931708 C11orf17;ST5 0.67 14.59 0.62 1.18e-37 Hemoglobin concentration; LUSC cis rs478304 0.903 rs1151502 chr11:65503485 G/C cg27068330 chr11:65405492 SIPA1 0.61 9.26 0.45 2.6e-18 Acne (severe); LUSC cis rs870825 0.616 rs9631783 chr4:185626511 C/T cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17133724 chr18:22932450 ZNF521 -0.44 -7.14 -0.36 5.85e-12 Electrocardiographic conduction measures; LUSC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg12751644 chr20:60527061 NA -0.36 -6.32 -0.33 8.56e-10 Body mass index; LUSC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg23758822 chr17:41437982 NA 1.04 19.19 0.72 7.41e-56 Menopause (age at onset); LUSC cis rs6754311 0.689 rs191079 chr2:136633771 T/C cg25344623 chr2:136566232 LCT -0.37 -5.65 -0.3 3.41e-8 Mosquito bite size; LUSC cis rs7177699 0.557 rs6495333 chr15:79113215 G/A cg00540400 chr15:79124168 NA 0.46 8.1 0.41 1.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2290416 0.892 rs76225457 chr8:144666052 G/T cg14809332 chr8:144654887 C8orf73 0.52 6.26 0.32 1.15e-9 Attention deficit hyperactivity disorder; LUSC cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg17691542 chr6:26056736 HIST1H1C 0.56 7.82 0.39 6.84e-14 Iron status biomarkers; LUSC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg06108461 chr20:60628389 TAF4 0.76 12.71 0.57 1.82e-30 Body mass index; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg23978390 chr7:1156363 C7orf50 0.45 6.43 0.33 4.3e-10 Longevity;Endometriosis; LUSC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg25208724 chr1:156163844 SLC25A44 1.1 26.31 0.82 2.03e-83 Testicular germ cell tumor; LUSC cis rs12928939 0.517 rs11865456 chr16:71969497 C/T cg03805757 chr16:71968109 PKD1L3 -0.63 -9.69 -0.47 1.01e-19 Post bronchodilator FEV1; LUSC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg07701084 chr6:150067640 NUP43 0.54 8.23 0.41 4.16e-15 Lung cancer; LUSC cis rs9910055 0.636 rs7089 chr17:42269017 T/C cg19774624 chr17:42201019 HDAC5 -0.8 -13.02 -0.58 1.22e-31 Total body bone mineral density; LUSC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg06558623 chr16:89946397 TCF25 -1.12 -10.49 -0.5 1.92e-22 Skin colour saturation; LUSC cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg22676075 chr6:135203613 NA 0.58 9.19 0.45 4.29e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs6960043 0.905 rs11514706 chr7:15059272 A/C cg19272540 chr7:15055459 NA -0.31 -7.28 -0.37 2.41e-12 Type 2 diabetes; LUSC cis rs9318086 0.935 rs9652081 chr13:24435510 C/T cg25267304 chr13:24462978 PCOTH;MIPEP -0.4 -6.14 -0.32 2.3e-9 Myopia (pathological); LUSC cis rs7851660 0.874 rs7037175 chr9:100631662 G/C cg13688889 chr9:100608707 NA -0.56 -8.91 -0.44 3.48e-17 Strep throat; LUSC cis rs9487051 0.735 rs351745 chr6:109529169 C/T cg01475377 chr6:109611718 NA 0.37 6.34 0.33 7.25e-10 Reticulocyte fraction of red cells; LUSC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg12463550 chr7:65579703 CRCP -0.5 -7.06 -0.36 9.91e-12 Aortic root size; LUSC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg17264618 chr3:40429014 ENTPD3 0.31 6.33 0.33 7.68e-10 Renal cell carcinoma; LUSC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs57378064 chr8:58169844 C/G cg21724239 chr8:58056113 NA 0.56 6.76 0.35 6.29e-11 Developmental language disorder (linguistic errors); LUSC cis rs3125734 0.660 rs10733769 chr10:63974255 G/T cg09941381 chr10:64027924 RTKN2 -0.38 -7.09 -0.36 8.05e-12 Rheumatoid arthritis; LUSC cis rs9549260 0.709 rs2721072 chr13:41144919 G/A cg21288729 chr13:41239152 FOXO1 0.57 8.63 0.43 2.55e-16 Red blood cell count; LUSC cis rs12421382 0.881 rs1808843 chr11:109389471 A/G cg11473876 chr11:109292803 C11orf87 0.42 6.97 0.36 1.69e-11 Schizophrenia; LUSC cis rs6977660 1.000 rs1468288 chr7:19810580 C/G cg07541023 chr7:19748670 TWISTNB 0.58 6.39 0.33 5.61e-10 Thyroid stimulating hormone; LUSC cis rs8114671 0.836 rs62213676 chr20:33612676 T/A cg24642439 chr20:33292090 TP53INP2 -0.4 -5.76 -0.3 1.92e-8 Height; LUSC cis rs2279817 1.000 rs10788680 chr1:18019454 A/G cg21791023 chr1:18019539 ARHGEF10L 0.5 7.12 0.36 6.56e-12 Neuroticism; LUSC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg03929089 chr4:120376271 NA -0.94 -16.46 -0.67 5.66e-45 Height; LUSC cis rs9399135 0.935 rs2150680 chr6:135347131 G/C cg24558204 chr6:135376177 HBS1L 0.59 9.28 0.45 2.26e-18 Red blood cell count; LUSC cis rs7804356 0.953 rs10227529 chr7:26886309 T/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg26314531 chr2:26401878 FAM59B -0.69 -9.41 -0.46 8.01e-19 Gut microbiome composition (summer); LUSC cis rs7771547 0.607 rs614028 chr6:36484252 G/A cg07856975 chr6:36356162 ETV7 0.37 6.61 0.34 1.48e-10 Platelet distribution width; LUSC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg19748678 chr4:122722346 EXOSC9 0.74 10.58 0.5 9.68e-23 Type 2 diabetes; LUSC cis rs8008758 0.517 rs1772028 chr14:101693861 C/G cg26224664 chr14:101693935 NA -0.37 -9.49 -0.46 4.7e-19 Body mass index (alcohol intake interaction); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg07990511 chr6:36853609 C6orf89 0.45 7.02 0.36 1.21e-11 Triglycerides; LUSC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg04944784 chr2:26401820 FAM59B -0.69 -9.74 -0.47 6.8e-20 Gut microbiome composition (summer); LUSC trans rs853679 0.546 rs200950 chr6:27835772 A/G cg06606381 chr12:133084897 FBRSL1 -0.81 -7.69 -0.39 1.71e-13 Depression; LUSC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg04546413 chr19:29218101 NA 0.63 8.3 0.41 2.69e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs17102884 0.600 rs9671386 chr14:75151047 G/A cg08847533 chr14:75593920 NEK9 0.45 5.84 0.3 1.22e-8 Neuroticism; LUSC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg02038168 chr22:39784481 NA -0.47 -7.53 -0.38 4.64e-13 Intelligence (multi-trait analysis); LUSC cis rs7707921 0.881 rs111907176 chr5:81312399 A/G cg15871215 chr5:81402204 ATG10 -0.44 -6.39 -0.33 5.65e-10 Breast cancer; LUSC cis rs4363385 0.647 rs56158137 chr1:152994380 A/T cg25856811 chr1:152973957 SPRR3 -0.4 -6.45 -0.33 3.88e-10 Inflammatory skin disease; LUSC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg26335602 chr6:28129616 ZNF389 0.42 5.71 0.3 2.52e-8 Depression; LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg16316162 chr8:144660157 NAPRT1 -0.68 -7.04 -0.36 1.12e-11 Attention deficit hyperactivity disorder; LUSC cis rs9287719 0.967 rs10203664 chr2:10752377 T/C cg00105475 chr2:10696890 NA 0.37 6.1 0.32 2.95e-9 Prostate cancer; LUSC cis rs2455601 1.000 rs72632952 chr11:8917976 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.88 -0.35 3.02e-11 Schizophrenia; LUSC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg23758822 chr17:41437982 NA 1.04 20.11 0.74 1.65e-59 Menopause (age at onset); LUSC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg07636037 chr3:49044803 WDR6 0.44 6.38 0.33 5.9e-10 Resting heart rate; LUSC cis rs3741404 0.609 rs687581 chr11:63871533 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.77 -12.65 -0.57 3.01e-30 Platelet count; LUSC cis rs1577917 1.000 rs12661204 chr6:86678586 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.25e-17 Response to antipsychotic treatment; LUSC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg18131467 chr2:239335373 ASB1 1.02 22.98 0.78 9.18e-71 Multiple system atrophy; LUSC cis rs10992471 0.603 rs7850528 chr9:95208992 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.44 -7.85 -0.39 5.82e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs10435719 0.647 rs10092605 chr8:11787395 T/G cg21775007 chr8:11205619 TDH 0.48 6.9 0.35 2.54e-11 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs6754311 0.678 rs309181 chr2:136614813 C/G cg25344623 chr2:136566232 LCT 0.37 5.68 0.3 2.96e-8 Mosquito bite size; LUSC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg11494091 chr17:61959527 GH2 0.4 6.91 0.35 2.47e-11 Height; LUSC cis rs4363385 0.626 rs12062770 chr1:153062837 A/C cg07796016 chr1:152779584 LCE1C -0.38 -5.73 -0.3 2.27e-8 Inflammatory skin disease; LUSC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg00033643 chr7:134001901 SLC35B4 0.44 6.55 0.34 2.18e-10 Mean platelet volume; LUSC cis rs9660992 0.508 rs113817010 chr1:205104581 C/A cg21545522 chr1:205238299 TMCC2 0.47 8.71 0.43 1.38e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs17445774 1.000 rs1509833 chr2:200865225 G/A cg23649088 chr2:200775458 C2orf69 0.65 9.42 0.46 7.51e-19 LDL cholesterol to HDL cholesterol ratio; LUSC trans rs7613875 0.521 rs4688754 chr3:50074641 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -8.0 -0.4 2.03e-14 Body mass index; LUSC cis rs7605827 0.930 rs13024782 chr2:15700715 A/G cg19274914 chr2:15703543 NA 0.46 8.64 0.43 2.43e-16 Educational attainment (years of education); LUSC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg08219700 chr8:58056026 NA 0.48 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.863 rs1155576 chr4:120450159 A/C cg24375607 chr4:120327624 NA 0.77 11.33 0.53 2.17e-25 Corneal astigmatism; LUSC cis rs8060686 0.623 rs2301814 chr16:68105171 C/G cg05110241 chr16:68378359 PRMT7 -0.45 -6.09 -0.32 3.19e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs34734847 0.898 rs696339 chr12:121169436 A/T cg27246729 chr12:121163418 ACADS 0.41 6.48 0.33 3.29e-10 Mean corpuscular volume; LUSC cis rs12908161 1.000 rs4643294 chr15:85250253 C/T cg12863693 chr15:85201151 NMB 0.42 8.76 0.43 1.02e-16 Schizophrenia; LUSC cis rs11030122 0.702 rs1013351 chr11:3952303 A/T cg18678763 chr11:4115507 RRM1 -0.45 -5.82 -0.3 1.34e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs2976388 0.934 rs2920279 chr8:143762135 A/C cg17252645 chr8:143867129 LY6D -0.36 -6.22 -0.32 1.52e-9 Urinary tract infection frequency; LUSC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg08859206 chr1:53392774 SCP2 0.65 12.19 0.55 1.6e-28 Monocyte count; LUSC cis rs10751667 1.000 rs7927156 chr11:970607 A/G cg01483505 chr11:975446 AP2A2 0.44 6.15 0.32 2.15e-9 Alzheimer's disease (late onset); LUSC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg09034736 chr1:150693464 HORMAD1 0.46 6.74 0.35 6.87e-11 Tonsillectomy; LUSC cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg08999081 chr20:33150536 PIGU 0.38 6.73 0.35 7.25e-11 Coronary artery disease; LUSC cis rs11608355 0.545 rs35422737 chr12:109911456 A/G cg05360138 chr12:110035743 NA 0.9 11.63 0.54 1.81e-26 Neuroticism; LUSC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.68 0.3 2.87e-8 Self-reported allergy; LUSC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg21862992 chr11:68658383 NA 0.51 8.09 0.4 1.11e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg12432903 chr7:1882776 MAD1L1 -0.38 -6.1 -0.32 2.87e-9 Bipolar disorder and schizophrenia; LUSC cis rs40363 1.000 rs1690443 chr16:3517787 C/G cg22508957 chr16:3507546 NAT15 0.85 11.01 0.52 2.87e-24 Tuberculosis; LUSC cis rs5758659 0.904 rs5758653 chr22:42613485 G/T cg15557168 chr22:42548783 NA -0.42 -7.11 -0.36 7.28e-12 Cognitive function; LUSC trans rs4927850 0.957 rs4927851 chr3:195751853 A/G cg16724585 chr3:197361211 NA -0.61 -8.64 -0.43 2.43e-16 Pancreatic cancer; LUSC cis rs9902453 0.808 rs76515799 chr17:28169491 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.2 0.45 3.86e-18 Coffee consumption (cups per day); LUSC cis rs12579753 0.872 rs34415838 chr12:82122078 T/C cg07988820 chr12:82153109 PPFIA2 -0.43 -6.12 -0.32 2.61e-9 Resting heart rate; LUSC cis rs713477 1.000 rs7142204 chr14:55908436 G/T cg04306507 chr14:55594613 LGALS3 0.29 5.7 0.3 2.63e-8 Pediatric bone mineral content (femoral neck); LUSC cis rs929354 0.772 rs3802126 chr7:156970281 G/A cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs1997103 0.954 rs2030807 chr7:55378485 A/G cg17469321 chr7:55412551 NA 0.69 10.95 0.51 4.64e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.8 -0.35 4.9e-11 Lung cancer; LUSC cis rs2742234 0.590 rs2435337 chr10:43661836 G/C cg15436174 chr10:43711423 RASGEF1A -0.43 -6.96 -0.36 1.78e-11 Hirschsprung disease; LUSC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg06634786 chr22:41940651 POLR3H 0.52 6.16 0.32 2.11e-9 Vitiligo; LUSC cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.22 0.37 3.61e-12 Rheumatoid arthritis; LUSC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg24562669 chr7:97807699 LMTK2 -0.4 -6.96 -0.36 1.85e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs34172651 0.917 rs7204281 chr16:24784475 C/T cg04756594 chr16:24857601 SLC5A11 0.37 6.1 0.32 2.92e-9 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.89 14.51 0.62 2.44e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2455601 0.671 rs10840135 chr11:8879794 T/C cg12365402 chr11:9010492 NRIP3 -0.36 -5.83 -0.3 1.34e-8 Schizophrenia; LUSC trans rs13314892 1.000 rs13318796 chr3:69795183 A/G cg26149728 chr3:119182545 TMEM39A -0.44 -5.95 -0.31 6.81e-9 QRS complex (12-leadsum); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06851941 chr3:33319219 FBXL2 -0.36 -6.07 -0.32 3.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg06873352 chr17:61820015 STRADA 0.68 12.14 0.55 2.36e-28 Prudent dietary pattern; LUSC trans rs6502050 0.835 rs28640920 chr17:80105151 A/T cg07393940 chr7:158741817 NA 0.36 6.56 0.34 2.09e-10 Life satisfaction; LUSC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg06238570 chr21:40685208 BRWD1 0.48 7.37 0.37 1.34e-12 Cognitive function; LUSC cis rs7843479 1.000 rs7843479 chr8:21820813 G/T cg17168535 chr8:21777572 XPO7 0.65 9.88 0.48 2.34e-20 Mean corpuscular volume; LUSC cis rs12618769 0.625 rs2278207 chr2:99163261 T/A cg10123293 chr2:99228465 UNC50 0.5 8.21 0.41 4.78e-15 Bipolar disorder; LUSC cis rs9653442 1.000 rs6712515 chr2:100806514 T/C cg22139774 chr2:100720529 AFF3 -0.44 -7.81 -0.39 7.69e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs7589342 0.566 rs11890447 chr2:106389691 T/C cg09152813 chr2:106391379 NCK2 -0.38 -6.16 -0.32 2.12e-9 Addiction; LUSC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg00745463 chr17:30367425 LRRC37B -0.8 -9.48 -0.46 4.95e-19 Hip circumference adjusted for BMI; LUSC cis rs12620999 0.774 rs13402764 chr2:237951984 C/T cg23555395 chr2:238036564 NA -0.37 -6.49 -0.33 3.1e-10 Systemic lupus erythematosus; LUSC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.91 16.04 0.66 2.56e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4689388 0.609 rs1046319 chr4:6304286 C/T cg14416269 chr4:6271139 WFS1 0.36 5.99 0.31 5.56e-9 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs4803468 0.967 rs4803462 chr19:41908936 T/A cg05360949 chr19:41903737 BCKDHA;EXOSC5 0.41 5.76 0.3 1.93e-8 Height; LUSC cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.98 17.96 0.7 5.97e-51 Chronic sinus infection; LUSC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg09365446 chr1:150670422 GOLPH3L 0.47 6.94 0.35 2.07e-11 Melanoma; LUSC cis rs7124681 0.584 rs7950674 chr11:47871017 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.8 0.35 4.78e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22385477 chr4:186392754 CCDC110 0.41 6.54 0.34 2.34e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9457247 1.000 rs394522 chr6:167398071 A/C cg20406979 chr6:167373233 NA 0.26 6.13 0.32 2.5e-9 Crohn's disease; LUSC cis rs7843479 0.965 rs9314269 chr8:21804989 A/G cg17168535 chr8:21777572 XPO7 0.68 10.58 0.5 9.26e-23 Mean corpuscular volume; LUSC trans rs11992162 0.967 rs10088415 chr8:11830825 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.04 -0.4 1.53e-14 Monocyte count; LUSC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg25019033 chr10:957182 NA -0.5 -6.2 -0.32 1.63e-9 Eosinophil percentage of granulocytes; LUSC cis rs12900413 0.687 rs72754547 chr15:90308166 A/C cg24249390 chr15:90295951 MESP1 -0.37 -5.87 -0.31 1.03e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs1322512 0.917 rs2758810 chr6:152963887 G/A cg27316956 chr6:152958899 SYNE1 -0.37 -6.33 -0.33 7.82e-10 Tonometry; LUSC cis rs281408 0.559 rs204248 chr19:49216224 G/C cg21064579 chr19:49206444 FUT2 -0.37 -6.37 -0.33 6.09e-10 Urinary metabolites (H-NMR features); LUSC cis rs7804356 1.000 rs3801813 chr7:26887069 T/C cg03456212 chr7:26904342 SKAP2 -0.53 -6.09 -0.32 3.04e-9 Type 1 diabetes; LUSC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.5 7.26 0.37 2.8e-12 Platelet count; LUSC cis rs1018836 0.892 rs4735224 chr8:91567046 C/A cg16814680 chr8:91681699 NA -0.69 -10.98 -0.52 3.69e-24 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7712401 0.601 rs246265 chr5:122254950 C/T cg19077854 chr5:122220652 SNX24 0.42 9.39 0.46 9.57e-19 Mean platelet volume; LUSC cis rs9341808 0.667 rs12209624 chr6:80919133 G/A cg08355045 chr6:80787529 NA 0.47 8.13 0.41 8.73e-15 Sitting height ratio; LUSC cis rs2463822 0.920 rs7924998 chr11:62073980 C/G cg06239285 chr11:62104954 ASRGL1 -0.87 -8.55 -0.42 4.36e-16 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11168351 0.864 rs10875743 chr12:48498413 C/T cg24011408 chr12:48396354 COL2A1 -0.39 -5.67 -0.3 3.16e-8 Bipolar disorder and schizophrenia; LUSC cis rs6516091 0.706 rs62199230 chr20:6050124 G/C cg25325723 chr20:6104886 FERMT1 -0.66 -7.08 -0.36 8.37e-12 Abdominal aortic aneurysm; LUSC cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg20908204 chr19:46285434 DMPK -0.38 -6.87 -0.35 3.07e-11 Coronary artery disease; LUSC cis rs4595586 0.545 rs11615634 chr12:39364704 A/C cg13010199 chr12:38710504 ALG10B 0.41 5.93 0.31 7.77e-9 Morning vs. evening chronotype; LUSC cis rs4805272 0.512 rs12373558 chr19:29337692 A/G cg12756686 chr19:29218302 NA 0.54 6.28 0.32 1.08e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs7824557 0.628 rs58283816 chr8:11192551 G/C cg15556689 chr8:8085844 FLJ10661 0.47 7.02 0.36 1.27e-11 Retinal vascular caliber; LUSC trans rs890100 0.673 rs11885335 chr2:56679612 C/T cg01657744 chr10:88471748 LDB3 0.45 6.14 0.32 2.4e-9 Gut microbiome composition (summer); LUSC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg12564285 chr5:131593104 PDLIM4 0.41 6.42 0.33 4.69e-10 Breast cancer; LUSC cis rs17001868 0.568 rs760700 chr22:40800071 C/T cg07138101 chr22:40742427 ADSL -0.64 -7.93 -0.4 3.23e-14 Mammographic density (dense area); LUSC cis rs73198271 0.515 rs78790301 chr8:8625786 G/C cg01851573 chr8:8652454 MFHAS1 0.62 7.34 0.37 1.61e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg08677398 chr8:58056175 NA 0.52 6.4 0.33 5.13e-10 Developmental language disorder (linguistic errors); LUSC cis rs208520 0.690 rs851464 chr6:66839802 C/T cg07460842 chr6:66804631 NA -1.14 -17.77 -0.7 3.45e-50 Exhaled nitric oxide output; LUSC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1865760 0.566 rs2032443 chr6:26046802 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.62 0.38 2.64e-13 Height; LUSC cis rs11958404 1.000 rs72816531 chr5:157413079 A/G cg05962755 chr5:157440814 NA 0.51 6.24 0.32 1.31e-9 IgG glycosylation; LUSC cis rs13401104 0.796 rs72620811 chr2:237118733 C/A cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.41e-8 Educational attainment; LUSC cis rs9815354 0.812 rs73071236 chr3:41992042 A/G cg03022575 chr3:42003672 ULK4 0.82 8.59 0.43 3.29e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.43 6.14 0.32 2.36e-9 Breast cancer; LUSC cis rs477692 1.000 rs531572 chr10:131427569 A/G cg11019008 chr10:131425282 MGMT -0.45 -6.92 -0.35 2.29e-11 Response to temozolomide; LUSC cis rs5769765 1.000 rs8138941 chr22:50290678 G/A cg08270630 chr22:50330655 NA -0.42 -6.25 -0.32 1.25e-9 Schizophrenia; LUSC cis rs2294693 0.945 rs9369255 chr6:40989503 T/C cg14769373 chr6:40998127 UNC5CL -0.58 -8.12 -0.41 9e-15 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs708547 0.624 rs1718886 chr4:57849251 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.55 8.24 0.41 3.88e-15 Response to bleomycin (chromatid breaks); LUSC cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg06784218 chr1:46089804 CCDC17 -0.58 -11.5 -0.53 5.39e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6121246 0.567 rs6088796 chr20:30213229 C/T cg18721089 chr20:30220636 NA -0.39 -6.12 -0.32 2.66e-9 Mean corpuscular hemoglobin; LUSC cis rs17270561 1.000 rs79867288 chr6:25828416 A/G cg17691542 chr6:26056736 HIST1H1C 0.76 9.71 0.47 8.44e-20 Iron status biomarkers; LUSC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg10909506 chr17:38081995 ORMDL3 0.34 6.05 0.31 3.93e-9 Asthma; LUSC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg01341218 chr17:43662625 NA 0.73 10.62 0.5 6.65e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg14784868 chr12:69753453 YEATS4 -0.66 -9.82 -0.47 3.64e-20 Blood protein levels; LUSC cis rs6582630 0.638 rs12425531 chr12:38550387 A/G cg26384229 chr12:38710491 ALG10B -0.54 -8.16 -0.41 6.75e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs12549902 0.933 rs17659428 chr8:41513809 T/C cg21772509 chr8:41503840 NKX6-3 0.64 10.42 0.5 3.4e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg16339924 chr4:17578868 LAP3 0.52 7.92 0.4 3.53e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9300255 0.739 rs1879380 chr12:123739111 G/A cg13010344 chr12:123464640 ARL6IP4 0.47 5.7 0.3 2.6e-8 Neutrophil percentage of white cells; LUSC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg09365446 chr1:150670422 GOLPH3L 0.54 8.25 0.41 3.72e-15 Tonsillectomy; LUSC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg05373962 chr22:49881684 NA -0.37 -8.79 -0.43 7.76e-17 Monocyte count;Monocyte percentage of white cells; LUSC cis rs9326248 0.520 rs7127881 chr11:116880798 G/A cg01368799 chr11:117014884 PAFAH1B2 0.58 9.17 0.45 4.9e-18 Blood protein levels; LUSC cis rs3806843 0.932 rs2563257 chr5:140140529 A/G cg19875535 chr5:140030758 IK -0.47 -7.7 -0.39 1.55e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs7712401 0.601 rs154496 chr5:122221731 A/G cg19077854 chr5:122220652 SNX24 0.4 9.11 0.45 7.67e-18 Mean platelet volume; LUSC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg04369109 chr6:150039330 LATS1 -0.57 -8.38 -0.42 1.51e-15 Lung cancer; LUSC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.93e-11 Blood metabolite levels; LUSC cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg27129171 chr3:47204927 SETD2 0.69 11.48 0.53 6.36e-26 Colorectal cancer; LUSC cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg24733560 chr20:60626293 TAF4 -0.4 -6.31 -0.33 8.85e-10 Body mass index; LUSC cis rs7312933 0.612 rs10785334 chr12:42620377 A/G cg17420585 chr12:42539391 GXYLT1 0.32 5.99 0.31 5.46e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg24739457 chr1:205821442 NA 0.41 7.28 0.37 2.46e-12 Menarche (age at onset); LUSC cis rs6545883 0.929 rs6545877 chr2:61741947 T/C cg15711740 chr2:61764176 XPO1 -0.5 -7.94 -0.4 3.03e-14 Tuberculosis; LUSC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg00166722 chr3:10149974 C3orf24 0.41 5.87 0.31 1.02e-8 Alzheimer's disease; LUSC cis rs950027 0.549 rs11070452 chr15:45594836 C/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.95 -0.4 2.93e-14 Response to fenofibrate (adiponectin levels); LUSC cis rs2197308 0.565 rs12809769 chr12:37909968 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs17125944 0.505 rs2295826 chr14:53174923 C/T cg13660082 chr14:53194042 PSMC6 0.73 6.82 0.35 4.16e-11 Alzheimer's disease (late onset); LUSC cis rs7432375 0.610 rs56695781 chr3:136510601 G/T cg15507776 chr3:136538369 TMEM22 0.44 7.3 0.37 2.16e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs1348850 0.958 rs10930801 chr2:178459861 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.04 0.31 4.02e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg13319975 chr6:146136371 FBXO30 0.48 7.37 0.37 1.31e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.529 rs2889528 chr20:30210021 C/T cg18721089 chr20:30220636 NA -0.39 -6.12 -0.32 2.66e-9 Mean corpuscular hemoglobin; LUSC cis rs61931739 0.612 rs2004961 chr12:33994599 A/G cg06521331 chr12:34319734 NA -0.42 -7.01 -0.36 1.35e-11 Morning vs. evening chronotype; LUSC cis rs9611519 0.929 rs9611465 chr22:41426139 G/A cg13813247 chr22:41461852 NA -0.37 -6.68 -0.34 9.83e-11 Neuroticism; LUSC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg13206674 chr6:150067644 NUP43 0.58 8.91 0.44 3.38e-17 Lung cancer; LUSC cis rs10072221 0.836 rs7718641 chr5:75708010 T/G cg03132911 chr5:75698732 IQGAP2 0.36 6.1 0.32 2.88e-9 Mean platelet volume; LUSC cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg16339924 chr4:17578868 LAP3 0.48 7.21 0.37 3.67e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1048238 0.506 rs848210 chr1:16259813 A/G cg22431228 chr1:16359049 CLCNKA 0.4 8.29 0.41 2.78e-15 Systolic blood pressure; LUSC cis rs10779751 1.000 rs4845986 chr1:11288633 G/C cg08854313 chr1:11322531 MTOR 0.89 14.88 0.63 9.08e-39 Body mass index; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg19823710 chr17:29233276 C17orf42 0.44 6.07 0.32 3.44e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg22875332 chr1:76189707 ACADM 0.77 10.28 0.49 1e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9646944 0.501 rs10197310 chr2:103020030 A/T cg20060108 chr2:102954350 IL1RL1 -0.48 -6.33 -0.33 7.81e-10 Blood protein levels; LUSC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg24675658 chr1:53192096 ZYG11B 0.59 9.22 0.45 3.51e-18 Monocyte count; LUSC trans rs7613875 0.641 rs6793528 chr3:50100188 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.84 -0.39 6.25e-14 Body mass index; LUSC cis rs6754311 0.731 rs12988076 chr2:136569848 C/A cg25344623 chr2:136566232 LCT 0.38 5.75 0.3 2.07e-8 Mosquito bite size; LUSC cis rs6961069 0.560 rs62461673 chr7:80237977 G/T cg04458919 chr7:80252533 CD36 -0.4 -7.15 -0.36 5.43e-12 Platelet count; LUSC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg03732007 chr1:2071316 PRKCZ -0.54 -9.56 -0.46 2.65e-19 Height; LUSC cis rs3818717 0.538 rs12945601 chr17:17653411 C/T cg09796270 chr17:17721594 SREBF1 0.41 7.33 0.37 1.8e-12 Lymphocyte counts; LUSC trans rs62103177 0.733 rs62096748 chr18:77619699 T/C cg14227996 chr4:17616232 MED28 0.8 8.15 0.41 7.21e-15 Opioid sensitivity; LUSC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg21782813 chr7:2030301 MAD1L1 0.52 9.32 0.45 1.63e-18 Autism spectrum disorder or schizophrenia; LUSC cis rs911119 1.000 rs3827142 chr20:23617007 G/A cg16589663 chr20:23618590 CST3 0.6 6.99 0.36 1.48e-11 Chronic kidney disease; LUSC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg03188948 chr7:1209495 NA 0.62 6.4 0.33 5.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.21 -0.37 3.86e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12760731 0.623 rs12038759 chr1:178262700 A/C cg00404053 chr1:178313656 RASAL2 0.49 5.92 0.31 7.85e-9 Obesity-related traits; LUSC cis rs7674212 0.541 rs2720460 chr4:104054686 C/T cg16532752 chr4:104119610 CENPE 0.46 6.62 0.34 1.45e-10 Type 2 diabetes; LUSC cis rs789859 1.000 rs789860 chr3:194405630 A/T cg02072170 chr3:194406190 FAM43A 0.36 7.59 0.38 3.1400000000000003e-13 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; LUSC cis rs6565180 0.926 rs12446288 chr16:30388709 A/G cg17640201 chr16:30407289 ZNF48 0.91 17.1 0.68 1.58e-47 Tonsillectomy; LUSC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg12560992 chr17:57184187 TRIM37 0.77 14.52 0.62 2.32e-37 Intelligence (multi-trait analysis); LUSC cis rs3106136 0.934 rs34145031 chr4:95167123 A/G cg11021082 chr4:95130006 SMARCAD1 -0.35 -6.02 -0.31 4.68e-9 Capecitabine sensitivity; LUSC cis rs9875589 0.509 rs4047237 chr3:14012861 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 6.81 0.35 4.61e-11 Ovarian reserve; LUSC cis rs6754311 0.731 rs218174 chr2:136658345 C/T cg07169764 chr2:136633963 MCM6 -0.46 -6.33 -0.33 8.01e-10 Mosquito bite size; LUSC cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg16339924 chr4:17578868 LAP3 0.55 8.37 0.42 1.57e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg22431228 chr1:16359049 CLCNKA 0.44 8.65 0.43 2.23e-16 Dilated cardiomyopathy; LUSC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.78 0.35 5.32e-11 Tonsillectomy; LUSC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg11764359 chr7:65958608 NA -0.58 -8.99 -0.44 1.87e-17 Aortic root size; LUSC cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg13010199 chr12:38710504 ALG10B 0.65 10.24 0.49 1.34e-21 Bladder cancer; LUSC cis rs9318086 0.935 rs9553083 chr13:24441525 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.39 -5.98 -0.31 5.87e-9 Myopia (pathological); LUSC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg03461704 chr1:205818484 PM20D1 0.36 5.82 0.3 1.39e-8 Menarche (age at onset); LUSC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.53 -7.25 -0.37 2.84e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.99 0.36 1.54e-11 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg00310523 chr12:86230176 RASSF9 -0.43 -7.89 -0.4 4.28e-14 Major depressive disorder; LUSC trans rs11935423 0.778 rs28595160 chr4:100502822 G/T cg02164153 chr5:172068145 NEURL1B -0.47 -6.05 -0.31 3.97e-9 Gut microbiome composition (summer); LUSC cis rs6939532 0.544 rs10946816 chr6:26361946 C/G cg09904177 chr6:26538194 HMGN4 -0.46 -6.68 -0.34 9.75e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs9323205 0.723 rs61985121 chr14:51705925 A/G cg23942311 chr14:51606299 NA -0.44 -8.46 -0.42 8.2e-16 Cancer; LUSC cis rs208520 0.690 rs12202401 chr6:66760544 A/G cg07460842 chr6:66804631 NA 1.09 17.2 0.69 6.12e-48 Exhaled nitric oxide output; LUSC cis rs9902453 0.904 rs12936302 chr17:28349476 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -10.54 -0.5 1.32e-22 Coffee consumption (cups per day); LUSC cis rs3099143 1.000 rs7178759 chr15:77143513 A/G cg21673338 chr15:77095150 SCAPER 0.73 7.98 0.4 2.44e-14 Recalcitrant atopic dermatitis; LUSC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.99 0.48 9.72e-21 Bipolar disorder; LUSC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg11764359 chr7:65958608 NA 0.54 6.93 0.35 2.14e-11 Aortic root size; LUSC cis rs8062405 1.000 rs4788102 chr16:28873398 G/A cg09754948 chr16:28834200 ATXN2L 0.41 5.87 0.31 1.03e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.84 0.39 6.07e-14 Prudent dietary pattern; LUSC cis rs701145 0.617 rs9820619 chr3:154028294 G/T cg10247383 chr3:153839028 SGEF -0.46 -5.66 -0.3 3.31e-8 Coronary artery disease; LUSC trans rs12153263 0.504 rs10941686 chr5:20284938 C/T cg07262001 chr22:42734088 NA -0.31 -6.02 -0.31 4.68e-9 Obstetric antiphospholipid syndrome; LUSC cis rs8060686 0.545 rs76495028 chr16:68177036 G/C cg09835421 chr16:68378352 PRMT7 -0.62 -6.35 -0.33 6.84e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs12579753 0.869 rs12366920 chr12:82223015 G/A cg21231944 chr12:82153410 PPFIA2 -0.39 -5.91 -0.31 8.57e-9 Resting heart rate; LUSC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.79 0.6 1.52e-34 Alzheimer's disease; LUSC cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg06092702 chr1:163392909 NA -0.44 -7.45 -0.38 7.89e-13 Motion sickness; LUSC cis rs9311676 0.632 rs11130637 chr3:58405573 C/G cg13750441 chr3:58318267 PXK 0.34 6.54 0.34 2.3e-10 Systemic lupus erythematosus; LUSC cis rs9796 0.870 rs2925345 chr15:41311799 T/C cg18705301 chr15:41695430 NDUFAF1 0.45 7.81 0.39 7.44e-14 Menopause (age at onset); LUSC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg13560548 chr3:10150139 C3orf24 0.5 6.88 0.35 2.95e-11 Alzheimer's disease; LUSC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg16606324 chr3:10149918 C3orf24 0.64 8.92 0.44 3.07e-17 Alzheimer's disease; LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg24675658 chr1:53192096 ZYG11B -0.58 -9.11 -0.45 7.66e-18 Monocyte count; LUSC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC cis rs10751667 0.621 rs7396107 chr11:970029 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.39 0.33 5.68e-10 Alzheimer's disease (late onset); LUSC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg17554472 chr22:41940697 POLR3H 0.48 5.91 0.31 8.32e-9 Vitiligo; LUSC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg23262073 chr20:60523788 NA -0.41 -5.82 -0.3 1.39e-8 Body mass index; LUSC cis rs262150 0.592 rs56062559 chr7:158769109 T/C cg09640425 chr7:158790006 NA 0.47 5.66 0.3 3.32e-8 Facial morphology (factor 20); LUSC cis rs7772486 0.875 rs10872582 chr6:146373061 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.04 -0.36 1.07e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs10751667 0.621 rs10794353 chr11:948740 A/G ch.11.42038R chr11:967971 AP2A2 0.42 6.2 0.32 1.62e-9 Alzheimer's disease (late onset); LUSC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg24829409 chr8:58192753 C8orf71 -0.62 -7.59 -0.38 3.17e-13 Developmental language disorder (linguistic errors); LUSC cis rs17818399 0.510 rs1451153 chr2:46799852 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.48 -6.97 -0.36 1.71e-11 Height; LUSC cis rs6545883 0.965 rs11887205 chr2:61774473 T/G cg15711740 chr2:61764176 XPO1 -0.5 -7.99 -0.4 2.17e-14 Tuberculosis; LUSC cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -9.85 -0.47 2.9e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7824557 0.872 rs2572431 chr8:11105077 C/T cg21775007 chr8:11205619 TDH -0.51 -7.45 -0.38 8.26e-13 Retinal vascular caliber; LUSC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg11764359 chr7:65958608 NA -0.62 -9.38 -0.46 1.03e-18 Aortic root size; LUSC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg24642844 chr7:1081250 C7orf50 -0.79 -10.39 -0.49 4.39e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 13.94 0.61 3.82e-35 Platelet count; LUSC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg13628971 chr7:2884303 GNA12 0.37 5.65 0.3 3.48e-8 Height; LUSC cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg20283391 chr11:68216788 NA -0.58 -8.31 -0.41 2.5e-15 Total body bone mineral density; LUSC cis rs9815354 1.000 rs13325965 chr3:41914942 G/T cg03022575 chr3:42003672 ULK4 0.64 6.89 0.35 2.78e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs7560272 0.502 rs13013228 chr2:73925216 G/A cg20560298 chr2:73613845 ALMS1 0.38 5.81 0.3 1.45e-8 Schizophrenia; LUSC cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 29.35 0.85 1.65e-94 Chronic sinus infection; LUSC cis rs1107366 1.000 rs9874508 chr3:125902417 A/G cg08481491 chr3:125900108 ALDH1L1 0.32 6.51 0.34 2.76e-10 Metabolite levels; LUSC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg10150615 chr22:24372951 LOC391322 0.34 5.82 0.3 1.39e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg04939294 chr16:67753445 GFOD2 0.38 6.1 0.32 2.97e-9 Triglycerides; LUSC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg16049864 chr8:95962084 TP53INP1 -0.58 -10.75 -0.51 2.36e-23 Type 2 diabetes; LUSC cis rs11098499 0.863 rs6858777 chr4:120475966 A/G cg09307838 chr4:120376055 NA 0.75 10.89 0.51 7.5e-24 Corneal astigmatism; LUSC cis rs2996428 0.561 rs12134919 chr1:3744641 G/A cg13057898 chr1:3703894 LRRC47 0.46 7.92 0.4 3.55e-14 Red cell distribution width; LUSC cis rs9457247 1.000 rs421214 chr6:167396629 A/G cg20406979 chr6:167373233 NA 0.26 6.12 0.32 2.64e-9 Crohn's disease; LUSC cis rs9296092 0.538 rs9469488 chr6:33517117 G/T cg13560919 chr6:33536144 NA -0.82 -15.66 -0.65 7.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7178375 0.607 rs7171212 chr15:31207711 C/T cg15020726 chr15:31196382 MTMR15 0.89 7.54 0.38 4.54e-13 Hypertriglyceridemia; LUSC trans rs61931739 0.534 rs1817761 chr12:34105719 C/T cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.69 11.6 0.54 2.27e-26 Menarche (age at onset); LUSC trans rs800082 0.531 rs2204603 chr3:144258720 T/A cg24215973 chr2:240111563 HDAC4 0.48 7.48 0.38 6.75e-13 Smoking behavior; LUSC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg21782813 chr7:2030301 MAD1L1 0.58 10.31 0.49 8.12e-22 Bipolar disorder and schizophrenia; LUSC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg24296786 chr1:45957014 TESK2 -0.52 -7.99 -0.4 2.23e-14 High light scatter reticulocyte count; LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.87 -12.37 -0.56 3.29e-29 Platelet count; LUSC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg25072359 chr17:41440525 NA 0.6 7.66 0.39 2.08e-13 Menopause (age at onset); LUSC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg01879757 chr17:41196368 BRCA1 -0.5 -8.06 -0.4 1.37e-14 Menopause (age at onset); LUSC cis rs3768617 0.754 rs6673768 chr1:182983396 G/T ch.1.3577855R chr1:183094577 LAMC1 0.59 8.48 0.42 7.31e-16 Fuchs's corneal dystrophy; LUSC cis rs11758351 0.789 rs2069020 chr6:26205500 C/T cg23601095 chr6:26197514 HIST1H3D 0.72 7.7 0.39 1.51e-13 Gout;Renal underexcretion gout; LUSC cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg06008330 chr7:65541103 ASL 0.39 6.03 0.31 4.37e-9 Aortic root size; LUSC trans rs28647808 0.881 rs4962047 chr9:136262916 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs2204008 0.619 rs8189576 chr12:38307275 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.98 -0.36 1.6e-11 Bladder cancer; LUSC cis rs9296092 0.517 rs55683509 chr6:33471077 A/G cg13560919 chr6:33536144 NA -0.78 -13.33 -0.59 8.65e-33 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg13319975 chr6:146136371 FBXO30 -0.53 -7.99 -0.4 2.18e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9814567 0.964 rs9815894 chr3:134282796 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -14.05 -0.61 1.51e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg01483505 chr11:975446 AP2A2 0.42 5.94 0.31 6.98e-9 Alzheimer's disease (late onset); LUSC trans rs11098499 0.863 rs11947234 chr4:120474859 A/G cg25214090 chr10:38739885 LOC399744 0.53 7.74 0.39 1.2e-13 Corneal astigmatism; LUSC cis rs2816062 0.735 rs2816045 chr1:18892999 A/G cg18795169 chr1:18902165 NA -1.0 -24.32 -0.8 6.64e-76 Urate levels in lean individuals; LUSC cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg15691649 chr6:25882328 NA -0.38 -6.22 -0.32 1.49e-9 Blood metabolite levels; LUSC cis rs12155623 0.619 rs17641604 chr8:49842784 C/T cg22283653 chr8:49824208 NA 0.34 6.61 0.34 1.51e-10 Sudden cardiac arrest; LUSC cis rs977987 0.800 rs4888378 chr16:75332041 A/G cg03315344 chr16:75512273 CHST6 0.47 8.82 0.43 6.26e-17 Dupuytren's disease; LUSC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg21972741 chr5:435613 AHRR 0.32 5.82 0.3 1.39e-8 Cystic fibrosis severity; LUSC cis rs6750047 0.546 rs10192788 chr2:38272672 C/T cg07380506 chr2:38303506 CYP1B1 0.45 6.23 0.32 1.43e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs2692947 0.637 rs1168967 chr2:96826016 A/G cg23100626 chr2:96804247 ASTL 0.25 6.26 0.32 1.2e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg03676636 chr4:99064102 C4orf37 0.35 7.6 0.38 2.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10193935 1.000 rs13386385 chr2:42436928 G/T cg27598129 chr2:42591480 NA -0.63 -8.6 -0.43 3.25e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs1113500 0.933 rs4517375 chr1:108638330 A/C cg06207961 chr1:108661230 NA -0.41 -7.72 -0.39 1.37e-13 Growth-regulated protein alpha levels; LUSC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg04511125 chr2:88470314 THNSL2 -0.44 -6.72 -0.35 7.71e-11 Response to metformin (IC50); LUSC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg02187348 chr16:89574699 SPG7 0.55 8.89 0.44 3.87e-17 Multiple myeloma (IgH translocation); LUSC cis rs983392 0.709 rs4939320 chr11:59981801 T/C cg02771260 chr11:59836817 MS4A3 -0.36 -5.96 -0.31 6.46e-9 Alzheimer's disease (late onset); LUSC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg19230755 chr7:65878503 NA -0.39 -5.64 -0.3 3.56e-8 Aortic root size; LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg11494091 chr17:61959527 GH2 0.63 13.39 0.59 4.87e-33 Prudent dietary pattern; LUSC cis rs2832077 0.824 rs4816333 chr21:30201777 C/G cg24692254 chr21:30365293 RNF160 -0.57 -7.14 -0.36 6.03e-12 Cognitive test performance; LUSC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg00310523 chr12:86230176 RASSF9 0.45 8.0 0.4 2.1e-14 Major depressive disorder; LUSC cis rs11608355 0.545 rs2302708 chr12:109893726 A/C cg05360138 chr12:110035743 NA 0.9 11.56 0.53 3.1e-26 Neuroticism; LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.43 6.88 0.35 3.03e-11 Menopause (age at onset); LUSC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg05082376 chr22:42548792 NA 0.43 6.53 0.34 2.43e-10 Schizophrenia; LUSC cis rs3796619 0.503 rs13147452 chr4:1078124 G/A cg04106633 chr4:1044584 NA 0.32 5.71 0.3 2.45e-8 Recombination rate (males); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08555112 chr17:48942811 TOB1 0.42 6.24 0.32 1.34e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs17270561 0.609 rs4132072 chr6:25717843 C/T cg17691542 chr6:26056736 HIST1H1C 0.57 7.87 0.4 5.03e-14 Iron status biomarkers; LUSC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg04369109 chr6:150039330 LATS1 -0.58 -8.58 -0.43 3.55e-16 Lung cancer; LUSC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.74 7.4 0.38 1.14e-12 Initial pursuit acceleration; LUSC cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.55 -10.82 -0.51 1.39e-23 Monocyte percentage of white cells; LUSC cis rs6088590 1.000 rs6120748 chr20:33458284 T/G cg24642439 chr20:33292090 TP53INP2 0.71 11.11 0.52 1.31e-24 Coronary artery disease; LUSC cis rs6977660 0.714 rs10260866 chr7:19793151 T/C cg07541023 chr7:19748670 TWISTNB 0.66 7.11 0.36 7.26e-12 Thyroid stimulating hormone; LUSC cis rs9650315 0.810 rs34426788 chr8:57202762 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.27 0.37 2.53e-12 Height; LUSC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg07701084 chr6:150067640 NUP43 0.54 8.14 0.41 7.94e-15 Lung cancer; LUSC cis rs7106204 0.513 rs2165784 chr11:24249360 C/A ch.11.24196551F chr11:24239977 NA 0.98 11.83 0.54 3.43e-27 Response to Homoharringtonine (cytotoxicity); LUSC cis rs11690935 0.959 rs6759575 chr2:172689068 C/T cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.49 -0.62 2.85e-37 Schizophrenia; LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 13.34 0.59 8.03e-33 Platelet count; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg24182508 chr19:54672312 TMC4 0.37 5.94 0.31 7.02e-9 Schizophrenia; LUSC cis rs1348850 0.574 rs11889488 chr2:178426793 A/G cg22681709 chr2:178499509 PDE11A 0.4 5.74 0.3 2.1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2294693 0.685 rs67525613 chr6:41008956 G/T cg14769373 chr6:40998127 UNC5CL -0.52 -6.36 -0.33 6.82e-10 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg27129171 chr3:47204927 SETD2 -0.58 -8.28 -0.41 2.99e-15 Birth weight; LUSC cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.51 0.34 2.81e-10 Coronary artery disease; LUSC cis rs6558174 0.965 rs4872524 chr8:22489537 A/G cg03733263 chr8:22462867 KIAA1967 0.45 6.19 0.32 1.76e-9 Breast cancer; LUSC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg11502198 chr6:26597334 ABT1 -0.63 -9.63 -0.47 1.53e-19 Intelligence (multi-trait analysis); LUSC trans rs9329221 0.638 rs7460436 chr8:10254322 C/T cg06636001 chr8:8085503 FLJ10661 0.55 7.34 0.37 1.69e-12 Neuroticism; LUSC cis rs11864453 0.786 rs1050362 chr16:72130815 C/A cg01557791 chr16:72042693 DHODH -0.51 -7.33 -0.37 1.74e-12 Fibrinogen levels; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg04746587 chr1:44435956 DPH2 0.39 6.01 0.31 4.76e-9 Schizophrenia; LUSC cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg07741184 chr6:167504864 NA 0.38 6.85 0.35 3.46e-11 Crohn's disease; LUSC cis rs2859741 0.528 rs3753776 chr1:37480144 C/T cg09363841 chr1:37513479 NA -0.39 -7.47 -0.38 7.2e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC trans rs7615952 0.799 rs13315434 chr3:125641394 T/G cg07211511 chr3:129823064 LOC729375 -1.23 -21.07 -0.76 2.67e-63 Blood pressure (smoking interaction); LUSC cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg04455712 chr21:45112962 RRP1B 0.45 8.62 0.43 2.66e-16 Mean corpuscular volume; LUSC cis rs2455601 0.638 rs11042148 chr11:9008674 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -6.52 -0.34 2.61e-10 Schizophrenia; LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg07507251 chr3:52567010 NT5DC2 0.33 6.3 0.33 9.25e-10 Bipolar disorder; LUSC cis rs6429082 0.782 rs704705 chr1:235612320 C/T cg26050004 chr1:235667680 B3GALNT2 -0.63 -8.55 -0.42 4.59e-16 Adiposity; LUSC trans rs1814175 0.935 rs1827017 chr11:49632592 C/G cg15704280 chr7:45808275 SEPT13 -1.08 -21.7 -0.76 9.49e-66 Height; LUSC cis rs7804356 0.954 rs3801809 chr7:26895456 G/A cg03456212 chr7:26904342 SKAP2 -0.52 -6.04 -0.31 4.16e-9 Type 1 diabetes; LUSC cis rs9648716 0.515 rs17695707 chr7:140563901 C/T cg23214464 chr7:140373596 ADCK2 0.66 5.78 0.3 1.75e-8 Type 2 diabetes; LUSC cis rs1559088 0.847 rs10423531 chr19:33600140 T/C cg17764715 chr19:33622953 WDR88 0.6 8.33 0.41 2.08e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9325144 0.671 rs35817541 chr12:38975001 T/C cg13010199 chr12:38710504 ALG10B -0.53 -8.19 -0.41 5.44e-15 Morning vs. evening chronotype; LUSC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg27535305 chr1:53392650 SCP2 0.4 7.28 0.37 2.39e-12 Monocyte count; LUSC cis rs4499344 0.730 rs7250272 chr19:33100338 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg09491104 chr22:46646882 C22orf40 -0.72 -7.44 -0.38 8.4e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs250677 0.958 rs36070 chr5:148417240 T/C cg23229984 chr5:148520753 ABLIM3 0.37 5.97 0.31 6.15e-9 Breast cancer; LUSC cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg07606381 chr6:8435919 SLC35B3 0.74 12.45 0.56 1.72e-29 Motion sickness; LUSC cis rs7264396 0.887 rs4911503 chr20:34063095 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -5.99 -0.31 5.46e-9 Total cholesterol levels; LUSC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg01874867 chr7:94954059 PON1 -0.42 -8.05 -0.4 1.49e-14 Paraoxonase activity; LUSC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg07835181 chr16:1525278 CLCN7 -0.72 -12.36 -0.56 3.84e-29 Bone mineral density; LUSC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg05368731 chr17:41323189 NBR1 0.93 16.17 0.66 7.55e-44 Menopause (age at onset); LUSC cis rs3540 0.553 rs2158406 chr15:90994499 T/C cg03599575 chr15:90893182 GABARAPL3 0.34 5.8 0.3 1.54e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs9296092 0.538 rs3916674 chr6:33522975 C/T cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.77e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs1044826 1.000 rs12695699 chr3:139176109 T/C cg00490450 chr3:139108681 COPB2 0.5 6.61 0.34 1.5e-10 Obesity-related traits; LUSC cis rs57502260 0.704 rs60538784 chr11:68386735 G/A cg20283391 chr11:68216788 NA -0.62 -5.86 -0.31 1.09e-8 Total body bone mineral density (age 45-60); LUSC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg04317338 chr11:64019027 PLCB3 -0.64 -7.53 -0.38 4.67e-13 Mean platelet volume; LUSC cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg26384229 chr12:38710491 ALG10B 0.89 15.25 0.64 3.11e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg27446573 chr6:127587934 RNF146 0.92 15.13 0.64 9.36e-40 Breast cancer; LUSC trans rs9393777 0.920 rs34071253 chr6:27391802 C/T cg01620082 chr3:125678407 NA -0.69 -6.84 -0.35 3.77e-11 Intelligence (multi-trait analysis); LUSC cis rs868036 1.000 rs1026731 chr15:68095018 G/A cg05925327 chr15:68127851 NA -0.32 -5.7 -0.3 2.67e-8 Restless legs syndrome; LUSC cis rs6565180 0.888 rs12447833 chr16:30390314 T/C cg17640201 chr16:30407289 ZNF48 0.89 14.89 0.63 8.55e-39 Tonsillectomy; LUSC cis rs41271473 0.519 rs9660783 chr1:228886880 C/T cg16512390 chr1:228756714 NA 0.49 7.02 0.36 1.23e-11 Chronic lymphocytic leukemia; LUSC cis rs7582720 1.000 rs72934738 chr2:203740861 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.56 0.42 4.25e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg27539214 chr16:67997921 SLC12A4 -0.59 -7.75 -0.39 1.11e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs7584330 0.554 rs10178682 chr2:238433818 T/G cg16989719 chr2:238392110 NA -0.39 -5.69 -0.3 2.79e-8 Prostate cancer; LUSC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg26597838 chr10:835615 NA 0.99 12.9 0.58 3.74e-31 Eosinophil percentage of granulocytes; LUSC cis rs3733418 0.929 rs13149062 chr4:165905360 T/G cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -5.93 -0.31 7.54e-9 Obesity-related traits; LUSC cis rs4604732 0.631 rs4436425 chr1:247632323 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.43 6.64 0.34 1.29e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs1448094 1.000 rs4919776 chr12:86353763 T/C cg00310523 chr12:86230176 RASSF9 0.36 6.5 0.34 2.85e-10 Major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17213946 chr1:43997516 PTPRF -0.47 -6.18 -0.32 1.91e-9 Bipolar disorder and schizophrenia; LUSC cis rs7819412 0.561 rs2001328 chr8:10987199 T/C cg21775007 chr8:11205619 TDH -0.53 -7.48 -0.38 6.65e-13 Triglycerides; LUSC cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.5e-9 Breast cancer; LUSC cis rs4423214 0.547 rs11234030 chr11:71236967 G/A cg05163923 chr11:71159392 DHCR7 -0.65 -6.82 -0.35 4.23e-11 Vitamin D levels; LUSC cis rs8060686 0.641 rs55725810 chr16:68189636 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs12464483 0.524 rs2602772 chr2:30885263 C/A cg12454169 chr2:30669597 LCLAT1 0.61 8.2 0.41 5.06e-15 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg06873352 chr17:61820015 STRADA 0.7 12.19 0.55 1.6e-28 Prudent dietary pattern; LUSC cis rs12908161 1.000 rs56864281 chr15:85357649 C/A cg17507749 chr15:85114479 UBE2QP1 0.54 6.49 0.33 3.11e-10 Schizophrenia; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.68 0.43 1.73e-16 Prudent dietary pattern; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19954146 chr6:1312822 FOXQ1 0.39 6.17 0.32 1.93e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg21724239 chr8:58056113 NA 0.55 6.25 0.32 1.24e-9 Developmental language disorder (linguistic errors); LUSC trans rs11250097 0.507 rs2409779 chr8:11311340 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.22 -0.37 3.43e-12 Neuroticism; LUSC cis rs4974559 0.947 rs28509315 chr4:1358107 C/T cg02980000 chr4:1222292 CTBP1 0.73 7.25 0.37 2.92e-12 Systolic blood pressure; LUSC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg08859206 chr1:53392774 SCP2 -0.66 -12.58 -0.57 5.43e-30 Monocyte count; LUSC cis rs2115630 0.691 rs61322921 chr15:85163638 T/C cg12863693 chr15:85201151 NMB -0.26 -5.97 -0.31 5.98e-9 P wave terminal force; LUSC cis rs1729951 0.575 rs361248 chr3:136709066 G/A cg12473912 chr3:136751656 NA 0.39 7.07 0.36 8.96e-12 Neuroticism; LUSC cis rs477692 1.000 rs473073 chr10:131429646 G/T cg26102564 chr10:131424627 MGMT 0.41 6.41 0.33 4.82e-10 Response to temozolomide; LUSC cis rs2346177 0.875 rs2166745 chr2:46646879 C/G cg02822958 chr2:46747628 ATP6V1E2 0.37 6.32 0.33 8.45e-10 HDL cholesterol; LUSC trans rs9291683 0.588 rs3756237 chr4:10013378 G/A cg26043149 chr18:55253948 FECH 0.49 7.28 0.37 2.43e-12 Bone mineral density; LUSC cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.25 34.18 0.88 4.53e-111 Chronic sinus infection; LUSC cis rs2274273 0.624 rs68138420 chr14:55777967 G/T cg04306507 chr14:55594613 LGALS3 0.49 10.11 0.48 3.86e-21 Protein biomarker; LUSC trans rs1325195 0.806 rs2816196 chr1:179103877 G/T cg11624085 chr17:8464688 MYH10 0.44 7.3 0.37 2.14e-12 IgE grass sensitization; LUSC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg14773178 chr5:1868261 NA 0.31 5.76 0.3 1.87e-8 Cardiovascular disease risk factors; LUSC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg09177884 chr7:1199841 ZFAND2A -0.58 -8.22 -0.41 4.44e-15 Longevity;Endometriosis; LUSC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg12292205 chr6:26970375 C6orf41 0.67 11.26 0.52 3.72e-25 Autism spectrum disorder or schizophrenia; LUSC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg03609598 chr5:56110824 MAP3K1 -0.38 -5.81 -0.3 1.48e-8 Initial pursuit acceleration; LUSC cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg06627628 chr2:24431161 ITSN2 -0.6 -7.34 -0.37 1.69e-12 Lymphocyte counts; LUSC cis rs11785400 0.793 rs4587307 chr8:143738529 G/A cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13055374 chr1:54872983 SSBP3 0.5 7.73 0.39 1.25e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs897080 0.552 rs1068714 chr2:44634063 T/C cg00619915 chr2:44497795 NA -0.41 -5.8 -0.3 1.54e-8 Height; LUSC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg06238570 chr21:40685208 BRWD1 -0.43 -6.54 -0.34 2.32e-10 Cognitive function; LUSC cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg23788917 chr6:8435910 SLC35B3 -0.51 -7.54 -0.38 4.59e-13 Motion sickness; LUSC cis rs10743315 0.557 rs17343287 chr12:19420064 T/C cg02471346 chr12:19282374 PLEKHA5 0.81 6.28 0.32 1.07e-9 Gut microbiota (bacterial taxa); LUSC cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg26408565 chr15:76604113 ETFA -0.45 -7.0 -0.36 1.43e-11 Blood metabolite levels; LUSC cis rs722599 0.683 rs8008475 chr14:75291900 C/T cg08847533 chr14:75593920 NEK9 0.44 6.21 0.32 1.58e-9 IgG glycosylation; LUSC cis rs2274273 1.000 rs1009977 chr14:55603002 T/G cg04306507 chr14:55594613 LGALS3 0.57 13.06 0.58 9.13e-32 Protein biomarker; LUSC cis rs11098499 0.863 rs11098532 chr4:120490726 C/A cg09307838 chr4:120376055 NA 0.74 10.76 0.51 2.3e-23 Corneal astigmatism; LUSC cis rs2070488 0.736 rs2070988 chr3:38437835 C/T cg24069376 chr3:38537580 EXOG 0.39 7.19 0.37 4.27e-12 Electrocardiographic conduction measures; LUSC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg19812747 chr11:111475976 SIK2 -0.55 -8.2 -0.41 5.19e-15 Primary sclerosing cholangitis; LUSC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg23093090 chr10:104574429 C10orf26 -0.38 -7.11 -0.36 6.95e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9527 0.615 rs2152915 chr10:104691732 A/T cg23093090 chr10:104574429 C10orf26 -0.36 -6.68 -0.34 1e-10 Arsenic metabolism; LUSC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 14.06 0.61 1.35e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3749237 1.000 rs3749237 chr3:49770032 C/T cg03060546 chr3:49711283 APEH 0.55 7.66 0.39 2.07e-13 Resting heart rate; LUSC cis rs453301 0.686 rs6601281 chr8:8911004 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.89 -0.35 2.83e-11 Joint mobility (Beighton score); LUSC cis rs1801251 1.000 rs778166 chr2:233664097 A/T cg25237894 chr2:233734115 C2orf82 0.35 6.44 0.33 4.25e-10 Coronary artery disease; LUSC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg09365446 chr1:150670422 GOLPH3L 0.48 7.05 0.36 1.05e-11 Melanoma; LUSC cis rs9633740 1.000 rs7896832 chr10:82257570 T/C cg01528321 chr10:82214614 TSPAN14 1.07 12.16 0.55 1.97e-28 Post bronchodilator FEV1; LUSC cis rs4900538 0.855 rs72698602 chr14:102880454 T/C cg18135206 chr14:102964638 TECPR2 -1.0 -19.03 -0.72 3.26e-55 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg13607699 chr17:42295918 UBTF 0.5 7.7 0.39 1.52e-13 Total body bone mineral density; LUSC cis rs4789693 0.544 rs4789770 chr17:80376655 C/T cg04308225 chr17:80449738 NA 0.4 6.13 0.32 2.47e-9 Glucocorticoid-induced osteonecrosis; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg04414720 chr1:150670196 GOLPH3L 0.56 9.09 0.45 8.97e-18 Tonsillectomy; LUSC cis rs12579753 0.917 rs7313521 chr12:82205656 G/A cg07988820 chr12:82153109 PPFIA2 -0.42 -6.04 -0.31 4.05e-9 Resting heart rate; LUSC cis rs400736 0.535 rs4418631 chr1:8174197 A/G cg25007680 chr1:8021821 PARK7 0.44 6.43 0.33 4.45e-10 Response to antidepressants and depression; LUSC cis rs2190422 0.677 rs2382694 chr7:103070983 A/G cg04218035 chr7:103086829 SLC26A5 0.32 6.29 0.33 1.01e-9 Morning vs. evening chronotype; LUSC cis rs1790761 0.692 rs1269981 chr11:67334959 G/A cg08355456 chr11:67383691 NA 0.37 6.88 0.35 2.97e-11 Mean corpuscular volume; LUSC cis rs6681460 1.000 rs10889634 chr1:67065911 A/G cg02459107 chr1:67143332 SGIP1 -0.46 -8.54 -0.42 4.68e-16 Presence of antiphospholipid antibodies; LUSC cis rs2075371 0.501 rs1613152 chr7:134019837 A/G cg11752832 chr7:134001865 SLC35B4 0.4 5.96 0.31 6.41e-9 Mean platelet volume; LUSC trans rs9388451 0.874 rs13209968 chr6:126089285 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.39 -0.46 9.86e-19 Brugada syndrome; LUSC cis rs6460942 0.630 rs1866650 chr7:12396897 C/T cg06484146 chr7:12443880 VWDE -0.59 -6.07 -0.32 3.49e-9 Coronary artery disease; LUSC cis rs12410462 0.892 rs75757169 chr1:227629855 A/G cg04117972 chr1:227635322 NA 0.62 7.06 0.36 9.84e-12 Major depressive disorder; LUSC trans rs637571 0.510 rs12575663 chr11:65574535 G/A cg17712092 chr4:129076599 LARP1B -0.71 -10.28 -0.49 1.02e-21 Eosinophil percentage of white cells; LUSC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg04111992 chr7:158790115 NA 0.43 7.04 0.36 1.09e-11 Facial morphology (factor 20); LUSC cis rs11098499 0.955 rs1511015 chr4:120170473 A/C cg24375607 chr4:120327624 NA 0.74 11.16 0.52 8.3e-25 Corneal astigmatism; LUSC cis rs7520050 0.966 rs12021587 chr1:46472759 G/T cg06784218 chr1:46089804 CCDC17 -0.29 -5.69 -0.3 2.78e-8 Red blood cell count;Reticulocyte count; LUSC trans rs10448080 0.959 rs4732873 chr8:28601554 A/C cg13109300 chr12:49488587 DHH 0.33 6.14 0.32 2.37e-9 Height; LUSC cis rs3857536 0.813 rs7771716 chr6:66946769 C/T cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs870825 0.616 rs57086463 chr4:185639525 G/A cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.21 0.32 1.54e-9 Neuroticism; LUSC trans rs629535 0.814 rs506931 chr8:70068129 T/G cg21567404 chr3:27674614 NA 0.98 15.66 0.65 7.7e-42 Dupuytren's disease; LUSC cis rs7089973 0.604 rs11196942 chr10:116596872 G/A cg25233709 chr10:116636983 FAM160B1 0.37 6.63 0.34 1.33e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg26818010 chr10:134567672 INPP5A -0.84 -10.95 -0.51 4.73e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg00990874 chr7:1149470 C7orf50 -0.6 -8.05 -0.4 1.51e-14 Bronchopulmonary dysplasia; LUSC cis rs7191700 0.578 rs243324 chr16:11354970 A/G cg00044050 chr16:11439710 C16orf75 0.68 12.23 0.56 1.12e-28 Multiple sclerosis; LUSC cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs6845621 0.689 rs1356464 chr4:18847496 G/A cg12196642 chr4:18937545 NA -0.32 -5.84 -0.3 1.24e-8 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs2479724 0.905 rs2149274 chr6:41839092 T/C cg17623882 chr6:41773611 USP49 -0.65 -11.06 -0.52 1.94e-24 Menarche (age at onset); LUSC cis rs2404602 0.647 rs10152247 chr15:76942252 T/G cg23625390 chr15:77176239 SCAPER -0.64 -9.78 -0.47 4.89e-20 Blood metabolite levels; LUSC cis rs737008 0.922 rs2070923 chr16:11369855 G/T cg00044050 chr16:11439710 C16orf75 0.57 8.84 0.44 5.52e-17 Obesity-related traits; LUSC cis rs62408225 0.802 rs4997561 chr6:90908057 C/T cg06866423 chr6:90926672 BACH2 0.44 6.95 0.36 1.88e-11 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg05552183 chr6:42928497 GNMT 0.48 8.21 0.41 4.86e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs9341808 0.754 rs3793000 chr6:80995137 G/A cg08355045 chr6:80787529 NA 0.56 9.8 0.47 4.14e-20 Sitting height ratio; LUSC cis rs701145 0.585 rs357473 chr3:153895147 C/T cg17054900 chr3:154042577 DHX36 0.7 7.21 0.37 3.87e-12 Coronary artery disease; LUSC cis rs10754283 0.967 rs6428562 chr1:90102665 G/A cg21401794 chr1:90099060 LRRC8C 0.65 9.79 0.47 4.51e-20 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs11711311 1.000 rs9827682 chr3:113450251 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.53 7.31 0.37 1.99e-12 IgG glycosylation; LUSC cis rs7568458 0.870 rs1058588 chr2:85808871 A/G cg02493740 chr2:85810744 VAMP5 0.34 5.99 0.31 5.3e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9660992 0.674 rs72745219 chr1:205262271 G/A cg21643547 chr1:205240462 TMCC2 -0.49 -9.3 -0.45 1.88e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg03060546 chr3:49711283 APEH 0.72 12.18 0.55 1.79e-28 Resting heart rate; LUSC cis rs2204008 0.805 rs10881112 chr12:37956611 G/A cg13010199 chr12:38710504 ALG10B -0.6 -9.09 -0.45 8.66e-18 Bladder cancer; LUSC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg24675056 chr1:15929824 NA 0.46 7.96 0.4 2.79e-14 Systolic blood pressure; LUSC cis rs1997103 1.000 rs1997103 chr7:55395390 C/G cg17469321 chr7:55412551 NA 0.65 10.42 0.5 3.41e-22 QRS interval (sulfonylurea treatment interaction); LUSC cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg25801113 chr15:45476975 SHF 0.35 7.22 0.37 3.5e-12 Uric acid levels; LUSC cis rs4689388 0.926 rs3889821 chr4:6282596 C/T cg25554036 chr4:6271136 WFS1 0.64 13.57 0.6 1.01e-33 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg23711669 chr6:146136114 FBXO30 -0.92 -17.7 -0.7 6.65e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg21960279 chr19:17905606 B3GNT3 0.39 6.09 0.32 3.14e-9 Tumor biomarkers; LUSC cis rs4629180 0.586 rs1159902 chr2:102133641 G/A cg04415270 chr2:102091202 RFX8 -0.46 -7.87 -0.4 5.05e-14 Chronic rhinosinusitis with nasal polyps; LUSC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg26354017 chr1:205819088 PM20D1 0.84 15.14 0.64 8.94e-40 Menarche (age at onset); LUSC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg00484396 chr16:3507460 NAT15 0.93 10.74 0.51 2.66e-23 Tuberculosis; LUSC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs7189233 0.531 rs7194730 chr16:53489190 A/T cg09728985 chr16:53543985 NA -0.31 -5.81 -0.3 1.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg05340658 chr4:99064831 C4orf37 0.66 11.37 0.53 1.54e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2456568 0.570 rs1518579 chr11:93656821 A/G cg26875233 chr11:93583750 C11orf90 -0.3 -5.86 -0.31 1.13e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg25456477 chr12:86230367 RASSF9 0.43 7.66 0.39 2.03e-13 Major depressive disorder; LUSC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg11598736 chr3:195384522 SDHAP2 0.6 6.8 0.35 4.77e-11 Lung disease severity in cystic fibrosis; LUSC cis rs1577917 1.000 rs10944169 chr6:86683036 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.71 -0.34 8.14e-11 Response to antipsychotic treatment; LUSC cis rs11190604 1.000 rs2495737 chr10:102338344 T/C cg16342193 chr10:102329863 NA -0.38 -6.98 -0.36 1.65e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4917833 0.789 rs11189619 chr10:100220012 C/T cg19043522 chr10:100227446 HPSE2 0.4 5.71 0.3 2.53e-8 Pediatric bone mineral density (femoral neck); LUSC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg13319975 chr6:146136371 FBXO30 0.45 7.02 0.36 1.24e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs61931739 0.500 rs11053246 chr12:34516620 C/T cg26384229 chr12:38710491 ALG10B 0.9 15.57 0.65 1.71e-41 Morning vs. evening chronotype; LUSC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.69 -0.34 9.57e-11 High light scatter reticulocyte count; LUSC cis rs950169 0.544 rs2036949 chr15:85163605 T/C cg17173187 chr15:85201210 NMB 0.49 9.25 0.45 2.65e-18 Schizophrenia; LUSC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg07701084 chr6:150067640 NUP43 0.53 7.81 0.39 7.32e-14 Lung cancer; LUSC cis rs4594175 0.926 rs10138345 chr14:51624651 A/G cg23942311 chr14:51606299 NA 0.31 5.76 0.3 1.87e-8 Cancer; LUSC cis rs939658 0.805 rs12902831 chr15:79433171 G/A cg17916960 chr15:79447300 NA -0.52 -10.39 -0.49 4.32e-22 Refractive error; LUSC trans rs10946292 0.656 rs1740 chr6:170441452 C/T cg17832364 chr10:94847294 NA 0.36 5.99 0.31 5.54e-9 Obesity-related traits; LUSC cis rs2625529 0.689 rs10851847 chr15:72111760 T/C cg16672083 chr15:72433130 SENP8 -0.46 -7.39 -0.37 1.19e-12 Red blood cell count; LUSC cis rs7799006 0.929 rs35629140 chr7:2257171 G/C cg12745145 chr7:2261452 MAD1L1 -0.3 -5.96 -0.31 6.43e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg27494647 chr7:150038898 RARRES2 0.47 7.29 0.37 2.19e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs2292864 0.764 rs2292867 chr17:45357489 C/T cg18085866 chr17:45331354 ITGB3 -0.65 -5.67 -0.3 3.12e-8 Left atrial antero-posterior diameter; LUSC cis rs9796 0.870 rs7162992 chr15:41290861 T/C cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.9 -0.35 2.59e-11 Menopause (age at onset); LUSC cis rs7089973 0.604 rs55759483 chr10:116573423 T/C cg03647239 chr10:116582469 FAM160B1 0.48 7.56 0.38 3.94e-13 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7829975 0.714 rs6994038 chr8:8660538 C/A cg15556689 chr8:8085844 FLJ10661 0.68 10.7 0.51 3.48e-23 Mood instability; LUSC trans rs17685 0.753 rs1637039 chr7:75693009 C/T cg19862616 chr7:65841803 NCRNA00174 1.12 19.65 0.73 1.08e-57 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC cis rs2760061 0.583 rs1636195 chr1:228211589 T/C cg02753203 chr1:228287806 NA 1.0 19.87 0.74 1.47e-58 Diastolic blood pressure; LUSC trans rs10885582 0.874 rs10885586 chr10:116357563 A/G cg01002288 chr1:43166549 YBX1 -0.37 -6.35 -0.33 7.06e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 9.78 0.47 4.96e-20 Bipolar disorder; LUSC cis rs9297145 1.000 rs10953280 chr7:98763405 A/G cg05967295 chr7:98741636 SMURF1 -0.93 -15.36 -0.64 1.22e-40 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.52 3.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs8060686 0.563 rs118005841 chr16:68157562 A/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.72 -0.3 2.41e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs11758351 1.000 rs112751982 chr6:26191958 C/T cg23601095 chr6:26197514 HIST1H3D 0.73 7.46 0.38 7.42e-13 Gout;Renal underexcretion gout; LUSC cis rs7000551 0.689 rs12545909 chr8:22310052 A/G cg12081754 chr8:22256438 SLC39A14 -0.46 -7.04 -0.36 1.12e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs2456568 0.548 rs4402256 chr11:93660803 T/C cg26875233 chr11:93583750 C11orf90 -0.31 -6.01 -0.31 4.85e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg01774158 chr5:133562094 PPP2CA 0.38 6.37 0.33 6.23e-10 Calcium levels; LUSC cis rs2404602 0.692 rs12911174 chr15:77149943 G/A cg26408565 chr15:76604113 ETFA -0.48 -7.58 -0.38 3.4e-13 Blood metabolite levels; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg07507251 chr3:52567010 NT5DC2 0.31 5.98 0.31 5.63e-9 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg15380588 chr6:144606480 NA -0.49 -6.12 -0.32 2.61e-9 Bipolar disorder and schizophrenia; LUSC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg24675658 chr1:53192096 ZYG11B -0.63 -9.93 -0.48 1.62e-20 Monocyte count; LUSC cis rs735539 0.645 rs6490601 chr13:21245897 G/A cg04906043 chr13:21280425 IL17D -0.47 -7.3 -0.37 2.06e-12 Dental caries; LUSC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg04317338 chr11:64019027 PLCB3 0.69 7.93 0.4 3.42e-14 Mean platelet volume; LUSC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg24503407 chr1:205819492 PM20D1 0.9 16.85 0.68 1.6e-46 Menarche (age at onset); LUSC cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg08085267 chr17:45401833 C17orf57 -0.55 -8.96 -0.44 2.32e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6494488 0.500 rs72742910 chr15:64841834 G/A cg08069370 chr15:64387884 SNX1 -0.64 -5.65 -0.3 3.48e-8 Coronary artery disease; LUSC cis rs1348850 0.526 rs6723063 chr2:178491398 C/T cg27490568 chr2:178487706 NA 0.59 7.82 0.39 7.04e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg21535247 chr6:8435926 SLC35B3 0.57 8.86 0.44 4.73e-17 Motion sickness; LUSC cis rs7246967 0.673 rs4414616 chr19:22832411 G/A cg23217946 chr19:22817039 ZNF492 0.49 6.91 0.35 2.52e-11 Bronchopulmonary dysplasia; LUSC cis rs7605827 0.930 rs4668904 chr2:15543642 C/G cg19274914 chr2:15703543 NA 0.45 8.52 0.42 5.5e-16 Educational attainment (years of education); LUSC cis rs12900413 0.687 rs28752094 chr15:90311645 G/A cg24249390 chr15:90295951 MESP1 -0.37 -5.85 -0.3 1.17e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs12618769 0.625 rs4850878 chr2:99112180 T/A cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs524023 0.881 rs544838 chr11:64429059 T/C cg19131476 chr11:64387923 NRXN2 -0.38 -10.5 -0.5 1.79e-22 Urate levels in obese individuals; LUSC cis rs4474465 0.850 rs4441045 chr11:78220436 G/T cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC trans rs7657257 1.000 rs12643722 chr4:15730103 A/C cg17675199 chr6:35436792 RPL10A -0.88 -6.15 -0.32 2.26e-9 Blood protein levels; LUSC trans rs877282 0.733 rs11253342 chr10:765072 A/G cg22713356 chr15:30763199 NA 1.07 14.26 0.62 2.27e-36 Uric acid levels; LUSC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg11608241 chr8:8085544 FLJ10661 -0.54 -8.08 -0.4 1.18e-14 Neuroticism; LUSC cis rs2762353 0.935 rs1165153 chr6:25817789 A/G cg03517284 chr6:25882590 NA -0.46 -8.18 -0.41 6.14e-15 Blood metabolite levels; LUSC trans rs800082 1.000 rs2575194 chr3:144284871 C/T cg24215973 chr2:240111563 HDAC4 0.47 7.17 0.37 4.98e-12 Smoking behavior; LUSC cis rs4780401 0.609 rs7205994 chr16:11815964 C/T cg01061890 chr16:11836724 TXNDC11 -0.56 -8.58 -0.42 3.69e-16 Rheumatoid arthritis; LUSC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg02951883 chr7:2050386 MAD1L1 -0.58 -10.62 -0.5 6.72e-23 Bipolar disorder and schizophrenia; LUSC cis rs9929218 1.000 rs12446575 chr16:68791644 C/G cg02972257 chr16:68554789 NA 0.43 5.89 0.31 9.18e-9 Colorectal cancer; LUSC cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg23711669 chr6:146136114 FBXO30 0.87 15.68 0.65 6.49e-42 Lobe attachment (rater-scored or self-reported); LUSC cis rs12210905 0.688 rs72841376 chr6:27456321 G/A cg08851530 chr6:28072375 NA 0.97 6.01 0.31 4.99e-9 Hip circumference adjusted for BMI; LUSC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg24296786 chr1:45957014 TESK2 0.53 8.37 0.42 1.57e-15 High light scatter reticulocyte count; LUSC trans rs12637928 0.580 rs13075977 chr3:110175685 C/T cg17371621 chr15:61264283 RORA 0.37 6.25 0.32 1.24e-9 Neuroticism; LUSC cis rs4629180 0.917 rs34217240 chr2:102136682 G/A cg04415270 chr2:102091202 RFX8 0.53 8.41 0.42 1.2e-15 Chronic rhinosinusitis with nasal polyps; LUSC cis rs892961 0.932 rs7224116 chr17:75413177 A/G cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC trans rs9291683 0.679 rs2241483 chr4:10099831 A/G cg26043149 chr18:55253948 FECH -0.55 -8.37 -0.42 1.63e-15 Bone mineral density; LUSC cis rs6665290 0.669 rs3738725 chr1:227174210 T/C cg10327440 chr1:227177885 CDC42BPA -1.11 -29.12 -0.85 1.12e-93 Myeloid white cell count; LUSC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg25456477 chr12:86230367 RASSF9 0.39 6.88 0.35 2.96e-11 Major depressive disorder; LUSC cis rs1385374 0.858 rs11059926 chr12:129294244 A/T cg09035930 chr12:129282057 SLC15A4 -0.64 -6.8 -0.35 4.96e-11 Systemic lupus erythematosus; LUSC cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg01579765 chr21:45077557 HSF2BP -0.48 -10.08 -0.48 4.95e-21 Mean corpuscular volume; LUSC trans rs877282 0.891 rs11253406 chr10:796297 G/A cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg06138931 chr13:21896616 NA 0.4 6.74 0.35 6.78e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg06740227 chr12:86229804 RASSF9 0.42 6.71 0.34 8.31e-11 Major depressive disorder; LUSC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.67 7.14 0.36 5.74e-12 Initial pursuit acceleration; LUSC trans rs1422110 0.879 rs1363268 chr5:85469695 C/T cg01787110 chr1:109008453 NBPF6 -0.48 -7.95 -0.4 2.86e-14 Attention function in attention deficit hyperactive disorder; LUSC cis rs7843479 0.898 rs4311656 chr8:21802276 T/G cg17168535 chr8:21777572 XPO7 0.69 10.61 0.5 7.14e-23 Mean corpuscular volume; LUSC cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.07 0.44 1.01e-17 Motion sickness; LUSC cis rs7582720 1.000 rs72936834 chr2:203771260 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.66 0.43 2.06e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg07677032 chr17:61819896 STRADA 0.52 8.69 0.43 1.68e-16 Prudent dietary pattern; LUSC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg00684032 chr4:1343700 KIAA1530 0.34 5.85 0.3 1.2e-8 Obesity-related traits; LUSC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg22800045 chr5:56110881 MAP3K1 0.43 6.09 0.32 3.19e-9 Breast cancer;Breast cancer (early onset); LUSC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg16325326 chr1:53192061 ZYG11B -0.97 -19.53 -0.73 3.44e-57 Monocyte count; LUSC cis rs60733400 0.817 rs4648657 chr1:2560735 A/G cg18854424 chr1:2615690 NA -0.5 -10.04 -0.48 6.48e-21 Multiple sclerosis; LUSC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg06008330 chr7:65541103 ASL 0.4 6.19 0.32 1.77e-9 Aortic root size; LUSC cis rs947211 0.898 rs1772153 chr1:205745782 C/T cg11965913 chr1:205819406 PM20D1 -0.48 -6.42 -0.33 4.66e-10 Parkinson's disease; LUSC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg19824325 chr16:58548873 SETD6 0.94 9.32 0.45 1.63e-18 Schizophrenia; LUSC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg27398817 chr8:82754497 SNX16 -0.66 -8.38 -0.42 1.47e-15 Diastolic blood pressure; LUSC cis rs6961069 0.527 rs3212161 chr7:80273358 T/C cg04458919 chr7:80252533 CD36 0.37 6.45 0.33 3.9e-10 Platelet count; LUSC cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg00857998 chr1:205179979 DSTYK 0.59 8.82 0.43 6.27e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6456156 0.565 rs6921588 chr6:167494397 G/T cg07741184 chr6:167504864 NA 0.41 6.61 0.34 1.53e-10 Primary biliary cholangitis; LUSC cis rs2307022 0.586 rs2279539 chr16:68395094 G/A cg02226672 chr16:68398533 SMPD3 0.3 5.71 0.3 2.54e-8 Body mass index; LUSC cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -8.54 -0.42 4.83e-16 Schizophrenia; LUSC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.56 0.34 2.1e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg12564285 chr5:131593104 PDLIM4 0.39 6.91 0.35 2.51e-11 Breast cancer; LUSC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -6.51 -0.34 2.8e-10 Developmental language disorder (linguistic errors); LUSC cis rs7582180 0.903 rs7562372 chr2:100906331 T/C cg08017756 chr2:100939284 LONRF2 -0.35 -5.85 -0.3 1.2e-8 Intelligence (multi-trait analysis); LUSC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg14582100 chr15:45693742 SPATA5L1 -0.57 -10.58 -0.5 9.31e-23 Homoarginine levels; LUSC cis rs12594515 0.967 rs11857628 chr15:45998206 C/T cg01629716 chr15:45996671 NA 0.39 5.88 0.31 9.74e-9 Waist circumference;Weight; LUSC cis rs11018904 0.906 rs17227345 chr11:89954685 A/T cg26834418 chr11:89957033 CHORDC1 0.48 6.01 0.31 4.96e-9 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7712401 0.601 rs257813 chr5:122217168 G/A cg19077854 chr5:122220652 SNX24 0.4 9.09 0.45 8.81e-18 Mean platelet volume; LUSC trans rs6858430 0.744 rs2200458 chr4:175741282 C/G cg23523129 chr19:11457176 TMEM205;CCDC159 0.44 6.47 0.33 3.46e-10 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs11098499 0.754 rs9991959 chr4:120253773 C/T cg24375607 chr4:120327624 NA -0.71 -11.7 -0.54 9.56e-27 Corneal astigmatism; LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg19318889 chr4:1322082 MAEA 0.77 14.38 0.62 7.9e-37 Longevity; LUSC cis rs9486719 1.000 rs11153058 chr6:97012746 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.93 -0.48 1.54e-20 Migraine;Coronary artery disease; LUSC cis rs1372520 0.748 rs990085 chr4:90754771 A/G cg15133208 chr4:90757351 SNCA -0.54 -8.22 -0.41 4.43e-15 Neuroticism; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.52 -7.01 -0.36 1.34e-11 Renal function-related traits (BUN); LUSC cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.31 -6.21 -0.32 1.59e-9 Cystic fibrosis severity; LUSC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg22437258 chr11:111473054 SIK2 0.49 6.63 0.34 1.34e-10 Primary sclerosing cholangitis; LUSC cis rs10484885 0.715 rs2585013 chr6:90553402 T/G cg13799429 chr6:90582589 CASP8AP2 -0.98 -13.49 -0.59 2.1e-33 QRS interval (sulfonylurea treatment interaction); LUSC cis rs1957429 0.901 rs1951491 chr14:65346950 G/A cg23373153 chr14:65346875 NA 1.09 12.86 0.58 4.86e-31 Pediatric areal bone mineral density (radius); LUSC cis rs7254114 0.686 rs7249565 chr19:11302807 C/T cg02815516 chr19:11306319 KANK2 -0.42 -8.96 -0.44 2.38e-17 Immature fraction of reticulocytes; LUSC cis rs478304 0.627 rs11227254 chr11:65454000 A/G cg27068330 chr11:65405492 SIPA1 -0.74 -10.3 -0.49 8.46e-22 Acne (severe); LUSC cis rs7107174 1.000 rs4945268 chr11:78037936 T/C cg02023728 chr11:77925099 USP35 0.47 6.76 0.35 6.01e-11 Testicular germ cell tumor; LUSC cis rs2540226 0.874 rs6731026 chr2:39977159 C/T cg23576258 chr2:39999331 THUMPD2 0.35 5.82 0.3 1.42e-8 Personality dimensions; LUSC cis rs1005224 0.963 rs2302592 chr14:76129287 C/G cg04684003 chr14:76127793 TTLL5;C14orf1 0.59 8.0 0.4 2.11e-14 Large artery stroke; LUSC trans rs12458462 0.892 rs35928863 chr18:77438956 A/G cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -6.8 -0.35 4.8e-11 Monocyte count; LUSC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.2 -0.41 5.27e-15 Lung cancer; LUSC cis rs1408224 0.576 rs7335684 chr13:47193696 G/A cg19833103 chr13:47126551 LRCH1 -0.39 -5.83 -0.3 1.29e-8 QRS complex (12-leadsum); LUSC cis rs7223966 1.000 rs2854219 chr17:61942682 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.61 0.34 1.57e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2354432 0.607 rs3820130 chr1:146724003 A/G cg25205988 chr1:146714368 CHD1L -1.0 -9.68 -0.47 1.09e-19 Mitochondrial DNA levels; LUSC cis rs6582630 0.615 rs12821226 chr12:38546406 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.16 -0.41 6.75e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs1797081 1.000 rs1797081 chr10:16874565 A/G cg23933602 chr10:16859644 RSU1 0.99 20.81 0.75 2.8e-62 Platelet distribution width; LUSC cis rs11608355 1.000 rs11608355 chr12:109879292 T/C cg19025524 chr12:109796872 NA -0.36 -5.65 -0.3 3.42e-8 Neuroticism; LUSC cis rs2969070 0.831 rs7799266 chr7:2506595 G/A cg03277898 chr7:2518824 NA -0.28 -5.92 -0.31 8.09e-9 Diastolic blood pressure; LUSC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg01819759 chr13:79234251 RNF219 0.6 8.09 0.4 1.14e-14 Large artery stroke; LUSC cis rs2762353 0.935 rs1165152 chr6:25818766 A/G cg15691649 chr6:25882328 NA -0.37 -5.85 -0.3 1.19e-8 Blood metabolite levels; LUSC cis rs2839186 0.749 rs62226488 chr21:47710517 C/T cg11766577 chr21:47581405 C21orf56 -0.42 -6.17 -0.32 1.98e-9 Testicular germ cell tumor; LUSC cis rs6121246 0.567 rs6058187 chr20:30190923 T/C cg18721089 chr20:30220636 NA -0.37 -5.81 -0.3 1.48e-8 Mean corpuscular hemoglobin; LUSC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg24531977 chr5:56204891 C5orf35 -0.58 -8.46 -0.42 8.46e-16 Breast cancer;Breast cancer (early onset); LUSC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.48 -7.03 -0.36 1.17e-11 Alzheimer's disease (late onset); LUSC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.56 8.36 0.42 1.68e-15 Total body bone mineral density; LUSC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg18876405 chr7:65276391 NA 0.75 13.51 0.59 1.81e-33 Calcium levels; LUSC cis rs6546550 0.935 rs6747542 chr2:70106832 T/C cg02498382 chr2:70120550 SNRNP27 -0.29 -7.17 -0.37 4.99e-12 Prevalent atrial fibrillation; LUSC cis rs10751667 0.621 rs10794351 chr11:946228 C/T ch.11.42038R chr11:967971 AP2A2 0.43 6.44 0.33 4.21e-10 Alzheimer's disease (late onset); LUSC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg08677398 chr8:58056175 NA 0.52 6.43 0.33 4.33e-10 Developmental language disorder (linguistic errors); LUSC cis rs10089 1.000 rs2054444 chr5:127493206 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.83 -11.43 -0.53 9.54e-26 Ileal carcinoids; LUSC cis rs2404602 0.716 rs4886817 chr15:76877702 C/T cg22467129 chr15:76604101 ETFA -0.45 -7.24 -0.37 3.04e-12 Blood metabolite levels; LUSC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg26314531 chr2:26401878 FAM59B -0.7 -9.68 -0.47 1.06e-19 Gut microbiome composition (summer); LUSC cis rs1801251 0.893 rs6733151 chr2:233592341 A/C cg08000102 chr2:233561755 GIGYF2 0.68 11.4 0.53 1.17e-25 Coronary artery disease; LUSC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.5 7.36 0.37 1.45e-12 Schizophrenia; LUSC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg12442385 chr7:1034912 NA 0.36 6.25 0.32 1.23e-9 Longevity;Endometriosis; LUSC cis rs1215050 0.791 rs7688192 chr4:98900798 G/T cg05340658 chr4:99064831 C4orf37 -0.44 -6.93 -0.35 2.19e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs701145 0.585 rs1470664 chr3:153865193 C/T cg17054900 chr3:154042577 DHX36 0.63 6.19 0.32 1.79e-9 Coronary artery disease; LUSC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg09359103 chr1:154839909 KCNN3 -0.71 -16.97 -0.68 4.99e-47 Prostate cancer; LUSC cis rs362272 0.545 rs2748447 chr4:3337831 G/A cg14583973 chr4:3374767 RGS12 0.36 7.51 0.38 5.36e-13 Serum sulfate level; LUSC cis rs2667011 0.512 rs1511217 chr2:160815093 T/C cg06573604 chr2:160760825 LY75 0.45 6.3 0.33 9.56e-10 Bilirubin levels; LUSC cis rs1577917 0.917 rs1838959 chr6:86556804 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.89 -0.44 3.82e-17 Response to antipsychotic treatment; LUSC cis rs1729951 0.575 rs35289288 chr3:136680568 C/T cg12473912 chr3:136751656 NA 0.39 6.77 0.35 5.97e-11 Neuroticism; LUSC trans rs9409565 0.826 rs9409556 chr9:97239268 T/C cg05679027 chr9:99775184 HIATL2 -0.45 -6.48 -0.33 3.23e-10 Colorectal cancer (alcohol consumption interaction); LUSC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg25072359 chr17:41440525 NA 0.67 9.62 0.47 1.68e-19 Menopause (age at onset); LUSC cis rs17253792 0.822 rs7145064 chr14:56088860 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.54 -0.34 2.24e-10 Putamen volume; LUSC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg17143192 chr8:8559678 CLDN23 0.62 9.06 0.44 1.12e-17 Obesity-related traits; LUSC cis rs10761482 0.500 rs1938543 chr10:62284660 A/T cg18175470 chr10:62150864 ANK3 -0.51 -7.4 -0.38 1.12e-12 Schizophrenia; LUSC cis rs12980942 0.630 rs7256856 chr19:41788352 A/G cg25627403 chr19:41769009 HNRNPUL1 0.59 6.49 0.33 3.13e-10 Coronary artery disease; LUSC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18404041 chr3:52824283 ITIH1 -0.47 -8.6 -0.43 3.22e-16 Bipolar disorder; LUSC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04402350 chr4:146857565 ZNF827 0.39 6.15 0.32 2.25e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9894429 0.624 rs9910935 chr17:79613949 T/C cg02117656 chr17:79614917 TSPAN10 0.31 5.66 0.3 3.3e-8 Eye color traits; LUSC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg04756594 chr16:24857601 SLC5A11 -0.48 -7.1 -0.36 7.43e-12 Intelligence (multi-trait analysis); LUSC cis rs6546550 0.867 rs6738174 chr2:70150215 A/C cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs561341 1.000 rs55643307 chr17:30263074 T/C cg00745463 chr17:30367425 LRRC37B -0.84 -9.21 -0.45 3.78e-18 Hip circumference adjusted for BMI; LUSC cis rs3770081 0.793 rs73943946 chr2:86226623 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.06 -6.77 -0.35 5.96e-11 Facial emotion recognition (sad faces); LUSC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg16606324 chr3:10149918 C3orf24 0.62 9.08 0.44 9.81e-18 Alzheimer's disease; LUSC cis rs9914988 0.537 rs28448745 chr17:27188296 A/C cg20469991 chr17:27169893 C17orf63 0.55 5.68 0.3 2.9e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg18132916 chr6:79620363 NA -0.37 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.733 rs12240638 chr10:35542610 G/T cg03585969 chr10:35415529 CREM 0.55 7.7 0.39 1.55e-13 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg05347473 chr6:146136440 FBXO30 0.52 8.87 0.44 4.42e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs4499344 0.664 rs259284 chr19:33163262 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.76 0.54 6.07e-27 Mean platelet volume; LUSC cis rs1949733 0.656 rs2631762 chr4:8423122 A/T cg13073564 chr4:8508604 NA -0.45 -8.63 -0.43 2.47e-16 Response to antineoplastic agents; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg16527491 chr14:38065127 FOXA1 0.39 6.04 0.31 4.21e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6840360 0.530 rs12645029 chr4:152650032 T/C cg22705602 chr4:152727874 NA -0.34 -6.69 -0.34 9.52e-11 Intelligence (multi-trait analysis); LUSC cis rs793571 0.566 rs610877 chr15:59103328 C/A cg05156742 chr15:59063176 FAM63B 0.58 8.53 0.42 5.28e-16 Schizophrenia; LUSC cis rs11785400 0.753 rs9773415 chr8:143731170 G/A cg24634471 chr8:143751801 JRK 0.51 7.25 0.37 2.9e-12 Schizophrenia; LUSC cis rs10740039 0.883 rs7088404 chr10:62393078 C/A cg18175470 chr10:62150864 ANK3 -0.47 -6.91 -0.35 2.46e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg11494091 chr17:61959527 GH2 0.67 14.33 0.62 1.28e-36 Prudent dietary pattern; LUSC cis rs950027 0.787 rs1153845 chr15:45724729 C/T cg26924012 chr15:45694286 SPATA5L1 -0.68 -10.82 -0.51 1.32e-23 Response to fenofibrate (adiponectin levels); LUSC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.18 0.32 1.87e-9 Menopause (age at onset); LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg25072359 chr17:41440525 NA 0.64 9.06 0.44 1.09e-17 Menopause (age at onset); LUSC cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.73 -9.41 -0.46 8.25e-19 Chronic sinus infection; LUSC cis rs1595825 0.838 rs73056856 chr2:198801209 C/G cg00982548 chr2:198649783 BOLL -0.57 -7.09 -0.36 7.99e-12 Ulcerative colitis; LUSC cis rs9462027 0.628 rs9469859 chr6:34722902 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.75 -0.3 2.01e-8 Systemic lupus erythematosus; LUSC cis rs9549367 0.756 rs9549702 chr13:113881944 T/G cg18105134 chr13:113819100 PROZ -0.67 -9.99 -0.48 9.94e-21 Platelet distribution width; LUSC cis rs798554 0.686 rs1713920 chr7:2880935 G/C cg02423579 chr7:2872169 GNA12 -0.44 -6.59 -0.34 1.73e-10 Height; LUSC trans rs11098499 0.955 rs35434465 chr4:120169378 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.44 6.05 0.31 3.98e-9 Corneal astigmatism; LUSC cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.74 0.65 3.64e-42 Drug-induced liver injury (flucloxacillin); LUSC cis rs7592578 0.766 rs35818159 chr2:191409616 C/G cg10560079 chr2:191398806 TMEM194B -0.72 -8.48 -0.42 7.41e-16 Diastolic blood pressure; LUSC cis rs10464366 0.560 rs11763728 chr7:39145862 C/T cg20302533 chr7:39170763 POU6F2 0.49 8.03 0.4 1.74e-14 IgG glycosylation; LUSC cis rs6700896 0.500 rs4655740 chr1:66084309 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.55 6.35 0.33 7.09e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7100689 0.646 rs1538823 chr10:82088040 C/A cg00277334 chr10:82204260 NA -0.58 -8.71 -0.43 1.47e-16 Post bronchodilator FEV1; LUSC trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg15704280 chr7:45808275 SEPT13 0.93 13.42 0.59 3.7e-33 Coronary artery disease; LUSC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg06219351 chr7:158114137 PTPRN2 0.49 8.85 0.44 5.12e-17 Calcium levels; LUSC cis rs7937682 0.921 rs34584980 chr11:111441537 G/A cg11344533 chr11:111475393 SIK2 0.48 6.29 0.33 9.78e-10 Primary sclerosing cholangitis; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.26 0.32 1.16e-9 Electroencephalogram traits; LUSC cis rs1448094 0.967 rs7313443 chr12:86332940 G/A cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.31e-9 Major depressive disorder; LUSC cis rs477692 0.870 rs532248 chr10:131414156 T/A cg11019008 chr10:131425282 MGMT 0.41 6.36 0.33 6.79e-10 Response to temozolomide; LUSC cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.94 -13.68 -0.6 4.06e-34 Chronic sinus infection; LUSC cis rs9486719 1.000 rs13202675 chr6:97028427 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -10.12 -0.48 3.69e-21 Migraine;Coronary artery disease; LUSC cis rs2730245 0.527 rs2527205 chr7:158706393 G/T cg24397884 chr7:158709396 WDR60 -0.78 -8.98 -0.44 2.02e-17 Height; LUSC trans rs1973993 0.691 rs1989141 chr1:96898520 C/T cg10631902 chr5:14652156 NA 0.62 11.08 0.52 1.61e-24 Weight; LUSC cis rs17255340 0.520 rs10806258 chr6:84116555 A/G cg08257003 chr6:84140564 ME1 0.36 8.88 0.44 4.2e-17 Platelet-derived growth factor BB levels; LUSC cis rs7084921 0.608 rs11592689 chr10:101865516 A/T cg02250046 chr10:101825185 CPN1 -0.35 -6.41 -0.33 5.08e-10 Bone mineral density; LUSC cis rs4595586 0.545 rs7952765 chr12:39375325 C/G cg26384229 chr12:38710491 ALG10B 0.49 6.96 0.36 1.77e-11 Morning vs. evening chronotype; LUSC cis rs925255 0.682 rs7590263 chr2:28645802 C/T cg01273330 chr2:28605224 NA -0.41 -6.47 -0.33 3.52e-10 Inflammatory bowel disease;Crohn's disease; LUSC trans rs7395662 0.591 rs4882012 chr11:48560597 T/A cg15704280 chr7:45808275 SEPT13 -0.46 -6.35 -0.33 6.87e-10 HDL cholesterol; LUSC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg11663144 chr21:46675770 NA 0.41 7.33 0.37 1.77e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs6964587 0.967 rs7801058 chr7:91784381 C/T cg17063962 chr7:91808500 NA 0.59 9.14 0.45 6.14e-18 Breast cancer; LUSC cis rs12681287 0.640 rs7841690 chr8:87365359 T/C cg27223183 chr8:87520930 FAM82B 0.55 7.37 0.37 1.34e-12 Caudate activity during reward; LUSC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg01448562 chr3:133502909 NA -0.66 -10.83 -0.51 1.27e-23 Iron status biomarkers; LUSC cis rs17001868 0.568 rs2075764 chr22:40758581 C/T cg07138101 chr22:40742427 ADSL 0.6 7.09 0.36 8.02e-12 Mammographic density (dense area); LUSC cis rs1949733 0.958 rs2631731 chr4:8429817 A/G cg11789530 chr4:8429930 ACOX3 0.64 9.93 0.48 1.56e-20 Response to antineoplastic agents; LUSC cis rs9581857 0.685 rs9319373 chr13:28042835 A/G cg22138327 chr13:27999177 GTF3A 0.76 8.33 0.41 2.11e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg02118635 chr17:56770003 RAD51C;TEX14 -0.39 -6.03 -0.31 4.43e-9 Intelligence (multi-trait analysis); LUSC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.08 0.55 4.15e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs4400599 0.618 rs9803862 chr1:154192143 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 0.36 6.0 0.31 5.07e-9 Platelet distribution width; LUSC cis rs4619890 0.528 rs62289340 chr4:7879027 C/T cg24250820 chr4:7887609 AFAP1 0.36 6.11 0.32 2.71e-9 Glaucoma (primary open-angle); LUSC cis rs77861329 1.000 rs876782 chr3:52107909 C/T cg08692210 chr3:52188851 WDR51A -0.8 -7.64 -0.39 2.31e-13 Macrophage inflammatory protein 1b levels; LUSC cis rs9467773 1.000 rs3736782 chr6:26505403 C/A cg05738196 chr6:26577821 NA 0.81 15.2 0.64 4.95e-40 Intelligence (multi-trait analysis); LUSC cis rs7916697 0.947 rs9783176 chr10:70002393 A/T cg06988349 chr10:69991859 ATOH7 0.34 5.97 0.31 6.15e-9 Optic disc area; LUSC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.88 -11.63 -0.54 1.72e-26 Platelet count; LUSC cis rs950169 0.580 rs11630887 chr15:85193015 A/T cg12863693 chr15:85201151 NMB 0.4 8.44 0.42 9.49e-16 Schizophrenia; LUSC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg26441486 chr22:50317300 CRELD2 -0.41 -5.8 -0.3 1.58e-8 Schizophrenia; LUSC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg26441486 chr22:50317300 CRELD2 0.45 6.8 0.35 4.81e-11 Schizophrenia; LUSC trans rs1908814 0.516 rs4840597 chr8:11796068 A/C cg14343924 chr8:8086146 FLJ10661 0.44 6.12 0.32 2.66e-9 Neuroticism; LUSC cis rs4356932 0.967 rs4859608 chr4:76991807 G/A cg00809888 chr4:76862425 NAAA 0.34 5.73 0.3 2.19e-8 Blood protein levels; LUSC cis rs477895 1.000 rs41294396 chr11:64078581 G/A cg04317338 chr11:64019027 PLCB3 0.55 5.7 0.3 2.62e-8 Mean platelet volume; LUSC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg02423579 chr7:2872169 GNA12 -0.45 -6.48 -0.33 3.24e-10 Height; LUSC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs7267979 0.903 rs6132819 chr20:25218618 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.07 0.66 1.96e-43 Liver enzyme levels (alkaline phosphatase); LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg06600287 chr1:53387719 ECHDC2 -0.3 -6.18 -0.32 1.91e-9 Monocyte count; LUSC cis rs1775715 0.966 rs1251386 chr10:32319114 C/T cg04359828 chr10:32216031 ARHGAP12 -0.34 -5.76 -0.3 1.87e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg12935359 chr14:103987150 CKB -0.52 -8.07 -0.4 1.26e-14 Body mass index; LUSC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg16060761 chr17:80687452 NA -0.52 -7.91 -0.4 3.93e-14 Glycated hemoglobin levels; LUSC cis rs1113500 0.862 rs11185264 chr1:108640506 T/C cg06207961 chr1:108661230 NA 0.41 7.49 0.38 6.32e-13 Growth-regulated protein alpha levels; LUSC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg24209194 chr3:40518798 ZNF619 0.49 6.46 0.33 3.75e-10 Renal cell carcinoma; LUSC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg08470875 chr2:26401718 FAM59B 0.72 9.82 0.47 3.79e-20 Gut microbiome composition (summer); LUSC cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg14438399 chr17:27053147 TLCD1 0.52 5.75 0.3 2.05e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs2040771 0.804 rs1091013 chr22:19248587 C/T cg02655711 chr22:19163373 SLC25A1 0.47 8.61 0.43 2.93e-16 Metabolite levels (small molecules and protein measures); LUSC cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg01324343 chr3:183735012 ABCC5 0.74 19.69 0.73 7.74e-58 Anterior chamber depth; LUSC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.49 -6.54 -0.34 2.26e-10 Tonsillectomy; LUSC cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg04450456 chr4:17643702 FAM184B 0.41 6.98 0.36 1.62e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg25072359 chr17:41440525 NA 0.66 9.43 0.46 7.13e-19 Menopause (age at onset); LUSC cis rs478304 0.593 rs4645933 chr11:65485120 C/T cg27068330 chr11:65405492 SIPA1 -0.76 -10.1 -0.48 4.33e-21 Acne (severe); LUSC cis rs1994135 0.654 rs11052759 chr12:33724126 G/A cg06521331 chr12:34319734 NA -0.4 -5.76 -0.3 1.87e-8 Resting heart rate; LUSC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg06221963 chr1:154839813 KCNN3 -0.49 -10.21 -0.49 1.74e-21 Prostate cancer; LUSC cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.52 7.07 0.36 9.34e-12 Multiple sclerosis; LUSC trans rs7980799 0.682 rs7311794 chr12:33635630 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.5 -0.42 6.36e-16 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg13944838 chr5:179740914 GFPT2 -0.59 -9.21 -0.45 3.6e-18 Height; LUSC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg12963246 chr6:28129442 ZNF389 0.52 7.24 0.37 3.17e-12 Depression; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07252851 chr5:74063056 GFM2;NSA2 -0.51 -6.4 -0.33 5.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs9308433 0.529 rs9430131 chr1:214481121 C/A cg06198575 chr1:214491504 SMYD2 0.46 7.14 0.36 5.73e-12 IgG glycosylation; LUSC cis rs10193935 0.901 rs9808509 chr2:42479644 T/C cg27598129 chr2:42591480 NA -0.63 -8.25 -0.41 3.58e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.32 -0.45 1.63e-18 Gut microbiome composition (summer); LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg17178900 chr1:205818956 PM20D1 0.74 11.81 0.54 3.83e-27 Menarche (age at onset); LUSC cis rs3760982 0.585 rs11083724 chr19:44298988 A/G cg11993925 chr19:44307056 LYPD5 0.36 7.86 0.4 5.35e-14 Breast cancer (estrogen-receptor negative);Breast cancer; LUSC cis rs10875746 0.903 rs61918806 chr12:48484433 G/A cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs1030877 0.960 rs3792049 chr2:105901908 A/C cg02079111 chr2:105885981 TGFBRAP1 -0.77 -14.09 -0.61 1.05e-35 Obesity-related traits; LUSC cis rs62103177 0.535 rs34299914 chr18:77949236 C/A cg20368463 chr18:77673604 PQLC1 0.66 6.66 0.34 1.12e-10 Opioid sensitivity; LUSC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg15556689 chr8:8085844 FLJ10661 0.68 11.38 0.53 1.45e-25 Mood instability; LUSC cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg15691649 chr6:25882328 NA -0.37 -6.1 -0.32 3e-9 Blood metabolite levels; LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.22 0.32 1.53e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6942756 1.000 rs67997229 chr7:128957366 G/C cg02491457 chr7:128862824 NA -0.47 -6.31 -0.33 9.1e-10 White matter hyperintensity burden; LUSC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg00989853 chr1:209979345 IRF6 0.3 6.6 0.34 1.62e-10 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); LUSC cis rs4820294 0.669 rs7287340 chr22:38054325 C/T cg21798802 chr22:38057573 PDXP 0.32 6.64 0.34 1.29e-10 Fat distribution (HIV); LUSC cis rs4774899 0.837 rs11636100 chr15:57414100 T/C cg21617494 chr15:57618479 NA -0.36 -6.04 -0.31 4.01e-9 Urinary tract infection frequency; LUSC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg06001716 chr17:41278141 BRCA1;NBR2 0.38 6.11 0.32 2.78e-9 Menopause (age at onset); LUSC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg18904891 chr8:8559673 CLDN23 -0.37 -5.75 -0.3 1.99e-8 Mood instability; LUSC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg13628971 chr7:2884303 GNA12 0.45 6.28 0.32 1.07e-9 Height; LUSC cis rs600231 0.508 rs35292734 chr11:65227700 C/T cg17120908 chr11:65337727 SSSCA1 -0.65 -9.5 -0.46 4.3e-19 Bone mineral density; LUSC cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg24397884 chr7:158709396 WDR60 0.75 12.09 0.55 3.55e-28 Height; LUSC cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg16586182 chr3:47516702 SCAP 0.56 8.79 0.43 8.18e-17 Colorectal cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20598768 chr1:154193039 C1orf43;UBAP2L 0.44 6.68 0.34 1.03e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg06219351 chr7:158114137 PTPRN2 -0.54 -9.85 -0.47 2.89e-20 Calcium levels; LUSC cis rs2439831 0.681 rs511673 chr15:43618863 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.91 10.47 0.5 2.17e-22 Lung cancer in ever smokers; LUSC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg03433033 chr1:76189801 ACADM 0.75 10.04 0.48 6.62e-21 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16218377 chr11:34073324 CAPRIN1 -0.4 -6.1 -0.32 3e-9 Electrocardiographic conduction measures; LUSC cis rs7927592 0.913 rs66752716 chr11:68273626 C/T cg16797656 chr11:68205561 LRP5 0.37 6.16 0.32 2.13e-9 Total body bone mineral density; LUSC trans rs10221833 0.602 rs355884 chr2:165633933 C/A cg26993132 chr16:89239499 CDH15 0.31 5.97 0.31 6.09e-9 Response to statin therapy; LUSC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg13206674 chr6:150067644 NUP43 0.58 9.05 0.44 1.17e-17 Lung cancer; LUSC cis rs11608355 0.515 rs7955932 chr12:109941303 G/A cg05360138 chr12:110035743 NA 0.93 12.36 0.56 3.76e-29 Neuroticism; LUSC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg25036284 chr2:26402008 FAM59B -0.75 -10.82 -0.51 1.4e-23 Gut microbiome composition (summer); LUSC cis rs4842666 0.831 rs12230074 chr12:90090867 A/G cg00757033 chr12:89920650 WDR51B 0.44 6.12 0.32 2.67e-9 Blood pressure; LUSC cis rs7618501 1.000 rs11130218 chr3:49752372 C/T cg13072238 chr3:49761600 GMPPB -0.38 -6.32 -0.33 8.2e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg20607798 chr8:58055168 NA 0.52 5.73 0.3 2.29e-8 Developmental language disorder (linguistic errors); LUSC cis rs742320 0.756 rs3765263 chr16:840378 A/G cg07501729 chr16:846077 CHTF18 0.38 6.31 0.33 9.08e-10 Mean corpuscular volume; LUSC cis rs9902453 0.817 rs12051834 chr17:28192785 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.67 0.47 1.16e-19 Coffee consumption (cups per day); LUSC cis rs4237845 0.837 rs7963992 chr12:58295949 G/C cg00677455 chr12:58241039 CTDSP2 0.5 7.63 0.39 2.52e-13 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.652 rs3759820 chr15:72300031 A/C cg16672083 chr15:72433130 SENP8 0.48 8.02 0.4 1.76e-14 Red blood cell count; LUSC cis rs17102423 0.602 rs1270073 chr14:65566257 C/A cg11161011 chr14:65562177 MAX -0.72 -10.93 -0.51 5.76e-24 Obesity-related traits; LUSC trans rs1994135 0.692 rs7958788 chr12:33692179 T/C cg26384229 chr12:38710491 ALG10B 0.61 8.51 0.42 5.98e-16 Resting heart rate; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05195756 chr6:91296664 MAP3K7 0.73 6.1 0.32 3e-9 Cognitive performance; LUSC cis rs9462027 0.628 rs10947531 chr6:34765118 A/C cg07306190 chr6:34760872 UHRF1BP1 0.33 5.94 0.31 7.28e-9 Systemic lupus erythematosus; LUSC cis rs6456156 0.586 rs720325 chr6:167467349 G/T cg06454157 chr6:167490870 NA -0.28 -6.65 -0.34 1.23e-10 Primary biliary cholangitis; LUSC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg12863693 chr15:85201151 NMB 0.35 7.13 0.36 6.42e-12 Schizophrenia; LUSC trans rs12310956 0.532 rs7306007 chr12:33975209 C/G cg13010199 chr12:38710504 ALG10B 0.52 7.71 0.39 1.5e-13 Morning vs. evening chronotype; LUSC cis rs9900062 1.000 rs2521879 chr17:62742678 A/G cg02598441 chr17:62777298 LOC146880 -0.62 -6.58 -0.34 1.78e-10 QT interval; LUSC cis rs2414059 0.518 rs56398519 chr15:50773432 A/G cg08437265 chr15:50716283 USP8 -0.4 -5.83 -0.3 1.27e-8 QT interval; LUSC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg16262614 chr3:133464971 TF 0.43 7.48 0.38 6.56e-13 Iron status biomarkers (transferrin levels); LUSC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg21963583 chr11:68658836 MRPL21 0.55 8.28 0.41 3.08e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs929354 0.772 rs6957939 chr7:156978485 T/C cg17757837 chr7:157058334 UBE3C 0.82 13.09 0.58 6.61e-32 Body mass index; LUSC cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs7824557 0.778 rs6601572 chr8:11093337 C/G cg21775007 chr8:11205619 TDH -0.52 -7.84 -0.39 5.97e-14 Retinal vascular caliber; LUSC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg14664628 chr15:75095509 CSK -0.55 -8.25 -0.41 3.67e-15 Breast cancer; LUSC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg07256732 chr16:621771 PIGQ -0.36 -6.54 -0.34 2.31e-10 Height; LUSC cis rs11971779 0.588 rs6972408 chr7:139071474 T/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs1775715 0.707 rs2808087 chr10:32146444 C/G cg04359828 chr10:32216031 ARHGAP12 0.41 7.09 0.36 8.13e-12 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs67478160 0.608 rs11628787 chr14:104323984 G/A cg08213375 chr14:104286397 PPP1R13B -0.45 -8.58 -0.42 3.63e-16 Schizophrenia; LUSC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg17279839 chr7:150038598 RARRES2 -0.45 -6.97 -0.36 1.67e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs3806843 0.576 rs155360 chr5:140309016 C/T cg19875535 chr5:140030758 IK 0.37 5.73 0.3 2.21e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg23711669 chr6:146136114 FBXO30 0.9 16.35 0.67 1.41e-44 Lobe attachment (rater-scored or self-reported); LUSC cis rs9486719 0.690 rs2092094 chr6:96844123 G/C cg06623918 chr6:96969491 KIAA0776 0.73 8.64 0.43 2.33e-16 Migraine;Coronary artery disease; LUSC trans rs1325195 0.920 rs2816206 chr1:179168805 C/G cg11624085 chr17:8464688 MYH10 0.44 6.91 0.35 2.49e-11 IgE grass sensitization; LUSC cis rs9902453 0.845 rs3115099 chr17:28019293 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.44 0.46 6.85e-19 Coffee consumption (cups per day); LUSC cis rs6732160 0.684 rs2043095 chr2:73407442 T/C cg24220031 chr2:73402428 NA -0.23 -5.79 -0.3 1.67e-8 Intelligence (multi-trait analysis); LUSC cis rs765787 0.530 rs2899378 chr15:45537584 C/T cg24006582 chr15:45444508 DUOX1 0.66 9.37 0.46 1.11e-18 Uric acid levels; LUSC trans rs3960554 0.600 rs2302429 chr7:75614777 G/A cg19862616 chr7:65841803 NCRNA00174 0.77 9.24 0.45 3.07e-18 Eotaxin levels; LUSC cis rs710216 0.917 rs900836 chr1:43412727 T/C cg03128534 chr1:43423976 SLC2A1 -0.45 -5.9 -0.31 8.85e-9 Red cell distribution width; LUSC cis rs75804782 0.521 rs2117691 chr2:239414734 C/T cg18131467 chr2:239335373 ASB1 -0.66 -6.01 -0.31 4.97e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs751728 0.664 rs4711349 chr6:33740592 C/T cg25922239 chr6:33757077 LEMD2 0.45 6.72 0.34 8e-11 Crohn's disease; LUSC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg14983838 chr19:29218262 NA 0.53 6.29 0.33 9.85e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg19626725 chr5:178986131 RUFY1 0.6 11.12 0.52 1.2e-24 Lung cancer; LUSC cis rs981844 0.712 rs897611 chr4:154755519 T/C cg14289246 chr4:154710475 SFRP2 -0.46 -6.3 -0.33 9.62e-10 Response to statins (LDL cholesterol change); LUSC cis rs11229555 0.645 rs12285111 chr11:58208385 T/G cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.58 -0.34 1.87e-10 Menopause (age at onset); LUSC cis rs877282 0.797 rs7079164 chr10:756363 A/G cg17470449 chr10:769945 NA 0.5 6.87 0.35 3.24e-11 Uric acid levels; LUSC trans rs10090774 0.965 rs11780104 chr8:142002107 C/T cg10310310 chr7:157367150 PTPRN2;MIR153-2 0.29 6.0 0.31 5.25e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11644478 chr21:40555479 PSMG1 -0.63 -9.51 -0.46 3.99e-19 Menarche (age at onset); LUSC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg23711669 chr6:146136114 FBXO30 0.9 17.22 0.69 5.08e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467773 1.000 rs3736781 chr6:26505362 G/A cg11502198 chr6:26597334 ABT1 0.59 9.08 0.44 9.97e-18 Intelligence (multi-trait analysis); LUSC cis rs714027 0.585 rs41173 chr22:30424863 C/G cg11564601 chr22:30592435 NA -0.35 -6.02 -0.31 4.6e-9 Lymphocyte counts; LUSC cis rs9389248 0.690 rs2294321 chr6:135253048 T/G cg22676075 chr6:135203613 NA -0.65 -10.27 -0.49 1.13e-21 High light scatter reticulocyte percentage of red cells; LUSC cis rs2282802 0.685 rs7737543 chr5:139646026 A/G cg26211634 chr5:139558579 C5orf32 0.44 8.32 0.41 2.31e-15 Intelligence (multi-trait analysis); LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg07677032 chr17:61819896 STRADA 0.53 9.01 0.44 1.62e-17 Prudent dietary pattern; LUSC trans rs8072100 0.764 rs2644349 chr17:45641743 G/A cg04995722 chr7:26192034 NFE2L3 0.38 6.2 0.32 1.67e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3857536 0.776 rs4710316 chr6:66935097 T/A cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs1419980 0.586 rs10845548 chr12:7777657 T/A cg10578777 chr12:7781093 NA -0.59 -6.45 -0.33 4e-10 HDL cholesterol levels; LUSC cis rs2404602 0.669 rs8036703 chr15:76951040 A/G cg26408565 chr15:76604113 ETFA -0.48 -7.63 -0.39 2.51e-13 Blood metabolite levels; LUSC cis rs68170813 0.599 rs11769901 chr7:106958505 G/A cg24556660 chr7:106842632 COG5;HBP1 -0.42 -5.83 -0.3 1.32e-8 Coronary artery disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10265308 chr14:21458149 METT11D1 -0.41 -6.01 -0.31 4.8e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21633795 chr20:52824352 PFDN4 0.81 6.47 0.33 3.4e-10 Cognitive performance; LUSC cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg20701182 chr2:24300061 SF3B14 0.88 11.42 0.53 1.05e-25 Lymphocyte counts; LUSC cis rs6430585 0.583 rs2304371 chr2:136561557 A/G cg07169764 chr2:136633963 MCM6 0.9 12.57 0.57 6.14e-30 Corneal structure; LUSC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg22529645 chr1:3704559 LRRC47 0.36 6.35 0.33 6.86e-10 Red cell distribution width; LUSC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.06 0.36 9.75e-12 Bipolar disorder; LUSC cis rs1559088 0.749 rs10405757 chr19:33616526 C/A cg17764715 chr19:33622953 WDR88 0.54 7.4 0.38 1.12e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs4794665 0.874 rs963292 chr17:54842555 C/T cg18503679 chr3:21792543 ZNF385D 0.37 6.02 0.31 4.61e-9 Height; LUSC cis rs10740039 0.768 rs10159993 chr10:62362546 T/A cg18175470 chr10:62150864 ANK3 -0.46 -6.87 -0.35 3.23e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs9815354 0.597 rs79626430 chr3:42023786 A/G cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs10740039 0.960 rs10761536 chr10:62404415 A/T cg18175470 chr10:62150864 ANK3 -0.46 -6.92 -0.35 2.38e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg03929089 chr4:120376271 NA 0.82 11.1 0.52 1.36e-24 Coronary artery disease; LUSC cis rs17401966 0.931 rs11584023 chr1:10302596 A/G cg19773385 chr1:10388646 KIF1B -0.6 -10.29 -0.49 9.18e-22 Hepatocellular carcinoma; LUSC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg15212455 chr7:39170539 POU6F2 0.65 11.25 0.52 3.95e-25 IgG glycosylation; LUSC cis rs7103648 0.864 rs10742802 chr11:47432725 T/G cg20307385 chr11:47447363 PSMC3 0.99 19.5 0.73 4.42e-57 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs6840360 0.642 rs10857260 chr4:152424056 C/G cg20465933 chr4:152376761 FAM160A1 0.32 5.81 0.3 1.45e-8 Intelligence (multi-trait analysis); LUSC cis rs714027 0.585 rs5763670 chr22:30383758 C/G cg11564601 chr22:30592435 NA 0.34 5.91 0.31 8.49e-9 Lymphocyte counts; LUSC cis rs1448094 0.935 rs11117120 chr12:86336447 G/A cg18827107 chr12:86230957 RASSF9 -0.4 -5.99 -0.31 5.56e-9 Major depressive disorder; LUSC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg02503808 chr4:7069936 GRPEL1 0.96 12.41 0.56 2.4e-29 Monocyte percentage of white cells; LUSC cis rs17621444 0.505 rs12359805 chr10:121798593 C/G cg02041677 chr10:121771263 NA 0.33 6.28 0.32 1.07e-9 IgG glycosylation; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 7.83 0.39 6.6e-14 Lymphocyte counts; LUSC cis rs11030122 0.661 rs12290747 chr11:3939650 T/C cg18678763 chr11:4115507 RRM1 -0.45 -5.8 -0.3 1.5e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs17345786 1.000 rs55641278 chr3:101290577 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 7.64 0.39 2.24e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs865483 0.965 rs853199 chr17:35850225 T/C cg06716730 chr17:35851459 DUSP14 0.29 6.61 0.34 1.53e-10 Monocyte count; LUSC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg08048268 chr3:133502702 NA -0.39 -7.0 -0.36 1.45e-11 Iron status biomarkers; LUSC cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs11229555 0.645 rs61889554 chr11:58424081 C/A cg15696309 chr11:58395628 NA -0.64 -6.76 -0.35 6.04e-11 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs453301 0.658 rs3855900 chr8:8901921 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.57 -0.38 3.59e-13 Joint mobility (Beighton score); LUSC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg01341218 chr17:43662625 NA -0.74 -10.73 -0.51 2.82e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg17366294 chr4:99064904 C4orf37 0.58 10.2 0.49 1.91e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg16325326 chr1:53192061 ZYG11B -0.82 -14.17 -0.61 5.03e-36 Monocyte count; LUSC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg07701084 chr6:150067640 NUP43 0.56 8.46 0.42 8.48e-16 Lung cancer; LUSC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg00343986 chr7:65444356 GUSB 0.44 6.73 0.35 7.5e-11 Aortic root size; LUSC cis rs561341 0.609 rs9906443 chr17:30185565 C/T cg13647721 chr17:30228624 UTP6 -0.69 -7.54 -0.38 4.54e-13 Hip circumference adjusted for BMI; LUSC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11890956 chr21:40555474 PSMG1 -1.04 -20.94 -0.75 8.8e-63 Cognitive function; LUSC cis rs9660992 0.573 rs1172147 chr1:205225457 G/A cg21545522 chr1:205238299 TMCC2 0.52 9.91 0.48 1.86e-20 Mean corpuscular volume;Mean platelet volume; LUSC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg02463440 chr8:22132932 PIWIL2 0.41 7.43 0.38 8.94e-13 Hypertriglyceridemia; LUSC cis rs667920 0.573 rs9682783 chr3:136539689 T/C cg15507776 chr3:136538369 TMEM22 0.61 8.47 0.42 8.08e-16 Coronary artery disease; LUSC cis rs79149102 0.579 rs7173218 chr15:75315328 A/G cg17294928 chr15:75287854 SCAMP5 -0.65 -5.94 -0.31 7.12e-9 Lung cancer; LUSC cis rs7829975 0.840 rs555617 chr8:8592845 C/G cg17143192 chr8:8559678 CLDN23 -0.39 -5.98 -0.31 5.68e-9 Mood instability; LUSC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg04317338 chr11:64019027 PLCB3 0.54 5.65 0.3 3.4e-8 Mean platelet volume; LUSC cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg15309053 chr8:964076 NA 0.34 7.11 0.36 7.26e-12 Schizophrenia; LUSC cis rs2762353 0.524 rs3923 chr6:25783315 T/C cg12310025 chr6:25882481 NA 0.37 6.27 0.32 1.12e-9 Blood metabolite levels; LUSC cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.27 0.32 1.13e-9 Tonsillectomy; LUSC trans rs7647973 0.667 rs11721148 chr3:49646669 G/A cg21659725 chr3:3221576 CRBN -0.72 -8.2 -0.41 5.17e-15 Menarche (age at onset); LUSC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg11663144 chr21:46675770 NA -0.42 -7.34 -0.37 1.66e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9354308 0.933 rs1938068 chr6:66607807 T/C cg07460842 chr6:66804631 NA 0.46 5.69 0.3 2.71e-8 Metabolite levels; LUSC cis rs908922 0.676 rs569032 chr1:152508615 C/T cg20991723 chr1:152506922 NA 0.51 9.65 0.47 1.34e-19 Hair morphology; LUSC cis rs1865760 0.566 rs2051544 chr6:26071093 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 8.2 0.41 5.32e-15 Height; LUSC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg23758822 chr17:41437982 NA 1.05 19.12 0.72 1.42e-55 Menopause (age at onset); LUSC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg12163867 chr12:51592794 POU6F1 -0.6 -10.59 -0.5 8.71e-23 Cisplatin-induced ototoxicity; LUSC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg03161606 chr19:29218774 NA 0.54 6.8 0.35 4.87e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs4663866 1.000 rs71426508 chr2:239137767 A/G cg16914508 chr2:239161102 PER2 0.59 6.22 0.32 1.5e-9 Irritable bowel syndrome; LUSC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg15782153 chr7:917662 C7orf20 0.42 6.44 0.33 4.07e-10 Perceived unattractiveness to mosquitoes; LUSC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg04362960 chr10:104952993 NT5C2 0.59 9.4 0.46 9.13e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.44 -0.33 4.08e-10 Alzheimer's disease (late onset); LUSC trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg23505145 chr19:12996616 KLF1 0.64 10.74 0.51 2.69e-23 Prostate cancer (SNP x SNP interaction); LUSC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg07741184 chr6:167504864 NA 0.36 6.49 0.33 3.03e-10 Crohn's disease; LUSC cis rs8062405 1.000 rs62036626 chr16:28844284 A/G cg09754948 chr16:28834200 ATXN2L 0.41 6.12 0.32 2.63e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg08677398 chr8:58056175 NA 0.52 6.87 0.35 3.18e-11 Developmental language disorder (linguistic errors); LUSC cis rs62400317 0.859 rs4479922 chr6:45248371 T/C cg20913747 chr6:44695427 NA -0.48 -7.73 -0.39 1.28e-13 Total body bone mineral density; LUSC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.07 0.44 1.05e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg07870213 chr5:140052090 DND1 0.78 11.57 0.53 2.8e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs3936840 0.752 rs2181343 chr14:102993303 A/C cg18135206 chr14:102964638 TECPR2 -0.55 -8.77 -0.43 9.35e-17 Plateletcrit; LUSC cis rs7927592 0.956 rs11228277 chr11:68308324 G/A cg20283391 chr11:68216788 NA -0.57 -8.14 -0.41 7.95e-15 Total body bone mineral density; LUSC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.14 -0.58 4.53e-32 Alzheimer's disease; LUSC cis rs4654899 0.865 rs12119348 chr1:21484633 C/T cg02927042 chr1:21476669 EIF4G3 -0.36 -5.69 -0.3 2.82e-8 Superior frontal gyrus grey matter volume; LUSC trans rs17685 0.725 rs1044483 chr7:75659815 T/C cg19862616 chr7:65841803 NCRNA00174 -1.14 -20.41 -0.74 1.07e-60 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs7584330 0.744 rs72620822 chr2:238379582 C/T cg16989719 chr2:238392110 NA -0.48 -7.69 -0.39 1.64e-13 Prostate cancer; LUSC cis rs16912285 0.688 rs12276587 chr11:24280656 C/G ch.11.24196551F chr11:24239977 NA -0.86 -9.31 -0.45 1.7e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs929354 0.772 rs2051876 chr7:157009037 A/G cg17757837 chr7:157058334 UBE3C -0.81 -12.97 -0.58 1.95e-31 Body mass index; LUSC cis rs3789045 0.560 rs3747634 chr1:204411063 C/T cg17419461 chr1:204415978 PIK3C2B 0.49 5.81 0.3 1.44e-8 Educational attainment (college completion); LUSC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -6.89 -0.35 2.85e-11 Lung cancer; LUSC cis rs870825 0.616 rs28607131 chr4:185651617 A/G cg04058563 chr4:185651563 MLF1IP 0.82 12.42 0.56 2.15e-29 Blood protein levels; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02522627 chr10:70715883 DDX21 0.48 6.39 0.33 5.64e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs877282 0.891 rs12767062 chr10:797961 C/T cg22713356 chr15:30763199 NA 1.11 15.86 0.66 1.27e-42 Uric acid levels; LUSC cis rs611744 0.647 rs1457211 chr8:109261318 C/T cg21045802 chr8:109455806 TTC35 -0.43 -6.63 -0.34 1.39e-10 Dupuytren's disease; LUSC cis rs9399135 0.967 rs7773126 chr6:135318390 A/G cg22676075 chr6:135203613 NA 0.49 7.68 0.39 1.72e-13 Red blood cell count; LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.07 0.4 1.27e-14 Bipolar disorder; LUSC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2273669 0.667 rs17070136 chr6:109350550 T/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.9 -0.31 9.1e-9 Prostate cancer; LUSC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg12963246 chr6:28129442 ZNF389 0.49 6.73 0.35 7.47e-11 Depression; LUSC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg20607287 chr7:12443886 VWDE -0.6 -6.26 -0.32 1.2e-9 Coronary artery disease; LUSC cis rs56399783 0.901 rs56007918 chr7:2826205 A/G cg19731401 chr7:2775893 GNA12 0.68 9.38 0.46 1.04e-18 Childhood ear infection; LUSC cis rs427941 0.668 rs201438 chr7:101735236 G/A cg06246474 chr7:101738831 CUX1 0.42 6.82 0.35 4.28e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4319547 0.626 rs11057882 chr12:122875046 A/G cg23029597 chr12:123009494 RSRC2 -0.75 -9.47 -0.46 5.19e-19 Body mass index; LUSC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg02269571 chr22:50332266 NA -0.66 -9.88 -0.48 2.39e-20 Schizophrenia; LUSC cis rs965513 1.000 rs925489 chr9:100546600 C/T cg13688889 chr9:100608707 NA -0.56 -8.42 -0.42 1.16e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs11676348 0.818 rs6436031 chr2:218979259 T/C cg00012203 chr2:219082015 ARPC2 -0.58 -9.25 -0.45 2.82e-18 Ulcerative colitis; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg09031657 chr21:48055629 PRMT2 0.71 6.05 0.31 3.98e-9 Body mass index; LUSC cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg22906224 chr7:99728672 NA 0.46 6.4 0.33 5.29e-10 Coronary artery disease; LUSC cis rs9611565 0.649 rs126092 chr22:42178441 A/G cg03806693 chr22:41940476 POLR3H 0.75 10.67 0.5 4.66e-23 Vitiligo; LUSC trans rs747782 0.527 rs75915859 chr11:48232931 C/T cg03929089 chr4:120376271 NA 0.66 6.15 0.32 2.2e-9 Intraocular pressure; LUSC cis rs2637266 0.935 rs12259550 chr10:78352843 A/G cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs3806843 0.966 rs6579965 chr5:140168811 T/G cg19875535 chr5:140030758 IK 0.51 8.37 0.42 1.55e-15 Depressive symptoms (multi-trait analysis); LUSC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg22532475 chr10:104410764 TRIM8 -0.3 -5.74 -0.3 2.16e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9815354 0.812 rs4547673 chr3:41952303 A/C cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs12210905 1.000 rs72843643 chr6:27211247 G/C cg11837749 chr1:55047332 ACOT11 0.58 5.98 0.31 5.64e-9 Hip circumference adjusted for BMI; LUSC cis rs4268898 0.662 rs2891380 chr2:24525830 G/A cg06627628 chr2:24431161 ITSN2 -0.86 -12.67 -0.57 2.64e-30 Asthma; LUSC cis rs1775715 0.707 rs2808079 chr10:32167385 C/T cg03015672 chr10:32216066 ARHGAP12 0.34 6.17 0.32 1.96e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs4919694 0.572 rs12240508 chr10:104939232 G/A cg04362960 chr10:104952993 NT5C2 0.9 11.46 0.53 7.33e-26 Arsenic metabolism; LUSC cis rs2247341 0.577 rs2236995 chr4:1704542 T/G cg05874882 chr4:1763078 NA -0.32 -5.99 -0.31 5.3e-9 Hip circumference adjusted for BMI;Height; LUSC cis rs9868809 0.505 rs13316551 chr3:48745167 A/C cg00383909 chr3:49044727 WDR6 1.14 10.32 0.49 7.24e-22 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; LUSC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg07424592 chr7:64974309 NA 0.63 5.69 0.3 2.81e-8 Diabetic kidney disease; LUSC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg11752832 chr7:134001865 SLC35B4 0.55 8.61 0.43 2.94e-16 Mean platelet volume; LUSC cis rs10465746 0.780 rs7551787 chr1:84419297 A/G cg10977910 chr1:84465055 TTLL7 0.47 6.83 0.35 4.13e-11 Obesity-related traits; LUSC trans rs61931739 0.500 rs11053208 chr12:34460029 A/G cg26384229 chr12:38710491 ALG10B 0.77 13.03 0.58 1.17e-31 Morning vs. evening chronotype; LUSC cis rs61931739 0.817 rs1705772 chr12:34174756 G/A cg06521331 chr12:34319734 NA -0.35 -6.01 -0.31 4.76e-9 Morning vs. evening chronotype; LUSC cis rs6964587 1.000 rs10488510 chr7:91660225 G/T cg17063962 chr7:91808500 NA 0.57 9.07 0.44 1.02e-17 Breast cancer; LUSC cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg06784218 chr1:46089804 CCDC17 0.49 9.66 0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9392556 0.829 rs620484 chr6:4114211 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.37 -6.42 -0.33 4.58e-10 Blood metabolite levels; LUSC cis rs11250098 0.548 rs7843470 chr8:10784492 C/G cg21775007 chr8:11205619 TDH -0.45 -6.0 -0.31 5.26e-9 Morning vs. evening chronotype; LUSC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg18512352 chr11:47633146 NA 0.47 9.53 0.46 3.24e-19 Subjective well-being; LUSC cis rs1949733 0.958 rs3103069 chr4:8509451 T/G cg11789530 chr4:8429930 ACOX3 -0.59 -8.81 -0.43 7.11e-17 Response to antineoplastic agents; LUSC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 13.59 0.6 8.31e-34 Platelet count; LUSC cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs832540 0.902 rs194059 chr5:56197416 G/A cg18230493 chr5:56204884 C5orf35 -0.57 -8.9 -0.44 3.61e-17 Coronary artery disease; LUSC cis rs72772090 0.539 rs11750934 chr5:96118487 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.58 -0.34 1.83e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs72781680 0.898 rs17509001 chr2:24021231 T/C cg08917208 chr2:24149416 ATAD2B 0.86 9.68 0.47 1.06e-19 Lymphocyte counts; LUSC cis rs11779988 0.630 rs17635854 chr8:17895734 A/G cg01800426 chr8:17659068 MTUS1 -0.42 -5.67 -0.3 3.05e-8 Breast cancer; LUSC cis rs9359856 0.636 rs3748085 chr6:90315789 C/T cg13799429 chr6:90582589 CASP8AP2 -0.66 -7.18 -0.37 4.61e-12 Bipolar disorder; LUSC cis rs2963155 0.518 rs865482 chr5:142640317 C/A cg17617527 chr5:142782415 NR3C1 0.71 8.61 0.43 2.97e-16 Breast cancer; LUSC cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg01884057 chr2:25150051 NA 0.48 11.42 0.53 1e-25 Body mass index; LUSC cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -8.09 -0.4 1.09e-14 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6977660 0.714 rs10155949 chr7:19834747 T/C cg07541023 chr7:19748670 TWISTNB 0.59 6.16 0.32 2.05e-9 Thyroid stimulating hormone; LUSC trans rs4718428 0.607 rs66954441 chr7:66369209 T/C cg18876405 chr7:65276391 NA 0.49 6.64 0.34 1.24e-10 Corneal structure; LUSC trans rs1005277 0.579 rs2474567 chr10:38382492 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.57 -0.46 2.51e-19 Extrinsic epigenetic age acceleration; LUSC cis rs751728 1.000 rs9394166 chr6:33751122 G/C cg25922239 chr6:33757077 LEMD2 0.54 8.11 0.41 9.86e-15 Crohn's disease; LUSC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg24977027 chr2:88469347 THNSL2 0.57 5.83 0.3 1.3e-8 Plasma clusterin levels; LUSC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 10.86 0.51 9.65e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs66887589 0.616 rs11098497 chr4:120187068 C/T cg24375607 chr4:120327624 NA 0.49 7.53 0.38 4.7e-13 Diastolic blood pressure; LUSC cis rs6940638 0.688 rs7764984 chr6:27034181 A/G cg12826209 chr6:26865740 GUSBL1 0.51 7.23 0.37 3.29e-12 Intelligence (multi-trait analysis); LUSC cis rs3099143 1.000 rs3110379 chr15:77095175 A/G cg21673338 chr15:77095150 SCAPER -0.82 -7.96 -0.4 2.67e-14 Recalcitrant atopic dermatitis; LUSC cis rs7647973 0.922 rs57273516 chr3:49483074 A/G cg07636037 chr3:49044803 WDR6 0.7 9.42 0.46 7.44e-19 Menarche (age at onset); LUSC cis rs1185460 0.967 rs1177562 chr11:118949331 C/T cg01677386 chr11:118938358 VPS11 -0.5 -7.02 -0.36 1.28e-11 Coronary artery disease; LUSC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg14604444 chr12:130766091 NA -0.32 -5.73 -0.3 2.22e-8 Menopause (age at onset); LUSC trans rs4332037 0.851 rs1403175 chr7:1964357 A/T cg25206134 chr2:45395956 NA -0.61 -7.07 -0.36 8.96e-12 Bipolar disorder; LUSC cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg23711669 chr6:146136114 FBXO30 0.75 13.4 0.59 4.72e-33 Lobe attachment (rater-scored or self-reported); LUSC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg00990874 chr7:1149470 C7orf50 -0.59 -7.78 -0.39 9.41e-14 Bronchopulmonary dysplasia; LUSC cis rs28647808 0.786 rs4962135 chr9:136256630 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A 0.7 6.9 0.35 2.55e-11 Blood protein levels; LUSC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg15691649 chr6:25882328 NA -0.4 -5.74 -0.3 2.15e-8 Intelligence (multi-trait analysis); LUSC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg03433033 chr1:76189801 ACADM 0.84 15.34 0.64 1.48e-40 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6977660 1.000 rs7791038 chr7:19798833 G/A cg05791153 chr7:19748676 TWISTNB 0.61 6.72 0.35 7.69e-11 Thyroid stimulating hormone; LUSC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg17264618 chr3:40429014 ENTPD3 0.29 6.16 0.32 2.07e-9 Renal cell carcinoma; LUSC cis rs56399783 0.808 rs73049331 chr7:2799911 C/T cg14895029 chr7:2775587 GNA12 0.52 6.17 0.32 1.93e-9 Childhood ear infection; LUSC cis rs7000551 0.751 rs2449341 chr8:22390937 C/A cg12081754 chr8:22256438 SLC39A14 0.43 6.43 0.33 4.47e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs17270561 0.609 rs1317510 chr6:25778924 T/C cg16482183 chr6:26056742 HIST1H1C 0.56 7.79 0.39 8.43e-14 Iron status biomarkers; LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.58 0.5 9.78e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg03146154 chr1:46216737 IPP -0.5 -7.23 -0.37 3.29e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7717823 0.900 rs344515 chr5:35025770 A/G cg12724942 chr10:75457680 AGAP5 0.28 5.95 0.31 6.88e-9 Urinary metabolites (H-NMR features); LUSC cis rs2522056 1.000 rs6874639 chr5:131778716 C/T cg24060327 chr5:131705240 SLC22A5 -0.48 -6.86 -0.35 3.33e-11 Lymphocyte counts;Fibrinogen; LUSC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg26408565 chr15:76604113 ETFA -0.51 -8.15 -0.41 7.31e-15 Blood metabolite levels; LUSC cis rs11756438 0.572 rs2638551 chr6:118998756 T/C cg18833306 chr6:118973337 C6orf204 0.36 5.73 0.3 2.2e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs9473147 0.543 rs9369716 chr6:47552180 A/T cg20196966 chr6:47445060 CD2AP 0.41 5.83 0.3 1.29e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg11645453 chr3:52864694 ITIH4 0.37 9.06 0.44 1.11e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs11608355 0.846 rs61934479 chr12:109855111 A/G cg05360138 chr12:110035743 NA 0.61 8.19 0.41 5.79e-15 Neuroticism; LUSC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg07936489 chr17:37558343 FBXL20 0.89 12.28 0.56 7.68e-29 Glomerular filtration rate (creatinine); LUSC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg09021430 chr5:549028 NA -0.55 -7.49 -0.38 6.11e-13 Obesity-related traits; LUSC cis rs7202877 0.561 rs2865532 chr16:75350975 A/G cg03315344 chr16:75512273 CHST6 0.42 5.99 0.31 5.34e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg03517284 chr6:25882590 NA -0.38 -6.8 -0.35 4.88e-11 Height; LUSC cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg15596816 chr17:45501030 LOC100272146;C17orf57 0.36 5.96 0.31 6.55e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs829883 0.639 rs829898 chr12:98857675 A/C cg25150519 chr12:98850993 NA 0.83 14.26 0.62 2.38e-36 Colorectal adenoma (advanced); LUSC cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg23711669 chr6:146136114 FBXO30 0.73 12.86 0.58 5.2500000000000004e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs7119 0.717 rs11634174 chr15:77811232 A/T cg27398640 chr15:77910606 LINGO1 -0.31 -6.74 -0.35 7.05e-11 Type 2 diabetes; LUSC cis rs11587400 0.634 rs7553926 chr1:115202215 A/G cg12756093 chr1:115239321 AMPD1 -0.42 -6.4 -0.33 5.12e-10 Autism; LUSC cis rs34779708 0.931 rs7923217 chr10:35309589 A/G cg04310649 chr10:35416472 CREM -0.39 -5.95 -0.31 6.77e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7246657 0.525 rs10401417 chr19:37467540 C/T cg23950597 chr19:37808831 NA -0.51 -5.65 -0.3 3.4e-8 Coronary artery calcification; LUSC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg12288994 chr5:1860383 NA 0.3 6.6 0.34 1.63e-10 Cardiovascular disease risk factors; LUSC trans rs12677056 0.651 rs17555872 chr8:113284490 T/C cg12159992 chr12:102059490 MYBPC1 0.36 6.1 0.32 2.88e-9 Peripheral artery disease; LUSC cis rs7180079 1.000 rs4238425 chr15:64671193 C/A cg08069370 chr15:64387884 SNX1 0.58 6.18 0.32 1.84e-9 Monocyte count; LUSC cis rs155346 1.000 rs265146 chr5:139398050 C/T cg01090482 chr5:139365336 NRG2 0.34 5.72 0.3 2.31e-8 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg14159672 chr1:205819179 PM20D1 0.89 16.3 0.67 2.43e-44 Menarche (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26482052 chr2:66660462 NA 0.43 6.3 0.33 9.52e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10876993 0.855 rs1689601 chr12:58049557 G/A cg18357645 chr12:58087776 OS9 0.51 7.64 0.39 2.33e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.89 0.48 2.14e-20 Bipolar disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06159435 chr11:118966351 H2AFX -0.55 -6.97 -0.36 1.74e-11 Bipolar disorder and schizophrenia; LUSC cis rs6496044 0.568 rs10468112 chr15:86073424 G/C cg13263323 chr15:86062960 AKAP13 -0.37 -6.16 -0.32 2.06e-9 Interstitial lung disease; LUSC cis rs354225 0.819 rs241661 chr2:54924467 G/T cg26097391 chr2:54893211 SPTBN1 0.37 5.9 0.31 8.71e-9 Schizophrenia; LUSC trans rs12614435 0.512 rs16866420 chr2:179491235 A/C cg14011486 chr1:26737247 LIN28 0.47 6.52 0.34 2.53e-10 Atrial fibrillation; LUSC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.74e-12 Resting heart rate; LUSC cis rs9650657 0.593 rs1968401 chr8:10615383 C/G cg27411982 chr8:10470053 RP1L1 -0.35 -5.74 -0.3 2.15e-8 Neuroticism; LUSC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg24881330 chr22:46731750 TRMU 0.89 8.94 0.44 2.7e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs17345786 0.906 rs58835747 chr3:101243634 T/C cg12386194 chr3:101231763 SENP7 0.62 8.52 0.42 5.75e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg13319975 chr6:146136371 FBXO30 -0.49 -7.22 -0.37 3.48e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg12292205 chr6:26970375 C6orf41 0.51 8.56 0.42 4.13e-16 Schizophrenia; LUSC cis rs11587682 0.760 rs12145082 chr1:150463526 T/C cg11822372 chr1:151115635 SEMA6C -0.42 -5.71 -0.3 2.53e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2295359 0.892 rs12401432 chr1:67656931 C/G cg17031739 chr1:67600172 NA 0.46 6.99 0.36 1.48e-11 Psoriasis; LUSC cis rs9300255 0.739 rs12824957 chr12:123750228 T/C cg13010344 chr12:123464640 ARL6IP4 0.57 6.7 0.34 8.65e-11 Neutrophil percentage of white cells; LUSC cis rs6667605 0.506 rs10797440 chr1:2541269 A/G cg18932078 chr1:2524107 MMEL1 0.28 6.16 0.32 2.09e-9 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs892961 0.932 rs7208671 chr17:75413129 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22590775 chr19:49891494 CCDC155 0.64 9.0 0.44 1.74e-17 Multiple sclerosis; LUSC cis rs11190604 1.000 rs1417823 chr10:102227886 C/T cg16342193 chr10:102329863 NA 0.33 6.31 0.33 8.93e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg09177884 chr7:1199841 ZFAND2A -0.46 -6.16 -0.32 2.13e-9 Longevity;Endometriosis; LUSC cis rs7577851 0.715 rs12466680 chr2:69638700 T/G cg10773587 chr2:69614142 GFPT1 0.56 6.3 0.33 9.29e-10 Parkinson's disease (age of onset); LUSC cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.21 -0.37 3.67e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg04362960 chr10:104952993 NT5C2 0.61 8.99 0.44 1.85e-17 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.61 10.54 0.5 1.27e-22 Menopause (age at onset); LUSC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg15445000 chr17:37608096 MED1 -0.41 -7.02 -0.36 1.21e-11 Glomerular filtration rate (creatinine); LUSC cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg16586182 chr3:47516702 SCAP -0.52 -7.99 -0.4 2.25e-14 Colorectal cancer; LUSC cis rs12760731 0.565 rs12044522 chr1:178190180 G/T cg00404053 chr1:178313656 RASAL2 0.66 6.86 0.35 3.32e-11 Obesity-related traits; LUSC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg24250549 chr1:154909240 PMVK -0.58 -9.19 -0.45 4.25e-18 Prostate cancer; LUSC cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg13010199 chr12:38710504 ALG10B 0.69 10.68 0.5 4.07e-23 Bladder cancer; LUSC cis rs75804782 0.625 rs1039887 chr2:239434892 A/G cg18131467 chr2:239335373 ASB1 -0.62 -6.79 -0.35 5.29e-11 Morning vs. evening chronotype;Chronotype; LUSC cis rs11971779 0.680 rs1133067 chr7:139053069 G/T cg23387468 chr7:139079360 LUC7L2 0.42 6.43 0.33 4.53e-10 Diisocyanate-induced asthma; LUSC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg16006841 chr5:176797999 RGS14 -0.81 -13.75 -0.6 2.17e-34 Hemoglobin concentration;Hematocrit; LUSC trans rs9388451 0.559 rs1777210 chr6:126098916 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.74 -12.79 -0.57 9.1e-31 Brugada syndrome; LUSC cis rs1790761 0.692 rs674783 chr11:67339076 C/T cg24690094 chr11:67383802 NA 0.44 8.5 0.42 6.36e-16 Mean corpuscular volume; LUSC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg27494647 chr7:150038898 RARRES2 0.5 7.58 0.38 3.53e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs10504073 0.647 rs11785310 chr8:50025035 G/A cg00325661 chr8:49890786 NA 0.62 10.03 0.48 7.44e-21 Blood metabolite ratios; LUSC cis rs1107366 0.722 rs10934753 chr3:125906179 G/A cg01346077 chr3:125931526 NA 0.34 6.44 0.33 4.06e-10 Metabolite levels; LUSC cis rs1577917 0.655 rs2758848 chr6:86347605 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -5.73 -0.3 2.23e-8 Response to antipsychotic treatment; LUSC cis rs9325144 0.647 rs34311455 chr12:39060889 C/T cg13010199 chr12:38710504 ALG10B -0.5 -7.73 -0.39 1.26e-13 Morning vs. evening chronotype; LUSC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg14895029 chr7:2775587 GNA12 0.43 6.77 0.35 5.92e-11 Height; LUSC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg03709012 chr19:19516395 GATAD2A -0.77 -11.95 -0.55 1.19e-27 Tonsillectomy; LUSC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg04518342 chr5:131593106 PDLIM4 0.55 10.34 0.49 6.47e-22 Acylcarnitine levels; LUSC cis rs8060686 0.623 rs7201591 chr16:68086105 A/G cg26727032 chr16:67993705 SLC12A4 -0.41 -6.43 -0.33 4.34e-10 HDL cholesterol;Metabolic syndrome; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09863175 chr15:57618660 NA 0.44 6.34 0.33 7.63e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg13089137 chr2:64068705 UGP2 0.43 6.06 0.31 3.59e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg05855489 chr10:104503620 C10orf26 0.69 10.16 0.49 2.54e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.44 0.42 9.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2048656 0.635 rs7830613 chr8:9649769 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.52 -0.34 2.53e-10 Schizophrenia; LUSC cis rs1419980 1.000 rs1419980 chr12:7774892 A/G cg14906510 chr12:7781169 NA -0.71 -6.5 -0.33 2.97e-10 HDL cholesterol levels; LUSC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg26408565 chr15:76604113 ETFA -0.5 -7.98 -0.4 2.42e-14 Blood metabolite levels; LUSC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7822232 1.000 rs7822232 chr8:145145687 A/C cg17475774 chr8:145118628 NA 0.48 6.77 0.35 5.73e-11 Blood metabolite levels; LUSC cis rs921968 0.591 rs6717107 chr2:219588697 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -10.3 -0.49 8.75e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg13798780 chr7:105162888 PUS7 0.57 6.09 0.32 3.04e-9 Bipolar disorder (body mass index interaction); LUSC cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.62 -0.34 1.44e-10 Monocyte percentage of white cells; LUSC cis rs2625529 0.824 rs16956452 chr15:72284092 T/C cg16672083 chr15:72433130 SENP8 -0.51 -7.41 -0.38 1.02e-12 Red blood cell count; LUSC cis rs1348850 0.918 rs12622298 chr2:178450651 C/T cg22681709 chr2:178499509 PDE11A -0.47 -8.43 -0.42 1.04e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs4927850 1.000 rs10881564 chr3:195750326 C/T cg21051086 chr3:73046214 PPP4R2 -0.52 -8.0 -0.4 2.13e-14 Pancreatic cancer; LUSC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg27535305 chr1:53392650 SCP2 0.33 5.97 0.31 6e-9 Monocyte count; LUSC cis rs4332037 1.000 rs10240470 chr7:1949971 G/T cg23422044 chr7:1970798 MAD1L1 0.63 7.26 0.37 2.72e-12 Bipolar disorder; LUSC cis rs6138458 0.887 rs227622 chr20:24910597 T/C cg06937882 chr20:24974362 C20orf3 -0.41 -6.94 -0.36 2.02e-11 Blood protein levels; LUSC cis rs11711311 0.955 rs67550112 chr3:113401988 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -6.06 -0.31 3.72e-9 IgG glycosylation; LUSC cis rs6087990 0.731 rs2424897 chr20:31338098 A/T cg13636640 chr20:31349939 DNMT3B 0.99 22.32 0.77 3.51e-68 Ulcerative colitis; LUSC cis rs55871839 0.598 rs4737525 chr8:59799781 G/A cg07426533 chr8:59803705 TOX -0.35 -5.67 -0.3 3.07e-8 Pneumonia; LUSC cis rs1107366 0.722 rs750714 chr3:125904688 G/A cg01346077 chr3:125931526 NA 0.35 6.64 0.34 1.28e-10 Metabolite levels; LUSC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg13319975 chr6:146136371 FBXO30 0.48 7.25 0.37 3.01e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg00046913 chr16:1877150 HAGH;FAHD1 0.66 6.87 0.35 3.08e-11 Glomerular filtration rate in chronic kidney disease; LUSC trans rs2204008 0.582 rs11179135 chr12:38204689 A/C cg06521331 chr12:34319734 NA -0.41 -6.13 -0.32 2.49e-9 Bladder cancer; LUSC cis rs9341808 0.690 rs6930534 chr6:80896050 C/T cg08355045 chr6:80787529 NA 0.59 10.22 0.49 1.58e-21 Sitting height ratio; LUSC cis rs4919087 1.000 rs3740512 chr10:99078745 C/T cg25902810 chr10:99078978 FRAT1 0.5 7.42 0.38 1.01e-12 Monocyte count; LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.97 0.4 2.55e-14 Alzheimer's disease; LUSC cis rs9300255 0.507 rs1615350 chr12:123650335 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.62 -0.34 1.46e-10 Neutrophil percentage of white cells; LUSC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg16647868 chr5:131706066 SLC22A5 0.39 5.97 0.31 6e-9 Breast cancer; LUSC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg07701084 chr6:150067640 NUP43 -0.54 -8.18 -0.41 5.9e-15 Lung cancer; LUSC trans rs800082 0.516 rs6765790 chr3:144225908 A/G cg24215973 chr2:240111563 HDAC4 0.45 6.76 0.35 6.03e-11 Smoking behavior; LUSC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg08499158 chr17:42289980 UBTF -0.52 -8.72 -0.43 1.36e-16 Total body bone mineral density; LUSC cis rs7786808 0.778 rs34212455 chr7:158224490 C/T cg01191920 chr7:158217561 PTPRN2 -0.59 -12.01 -0.55 7.1e-28 Obesity-related traits; LUSC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg06484146 chr7:12443880 VWDE -0.66 -8.15 -0.41 7.15e-15 Coronary artery disease; LUSC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.46 -6.89 -0.35 2.77e-11 Alzheimer's disease (late onset); LUSC cis rs7267979 1.000 rs6037086 chr20:25306338 A/G cg03522245 chr20:25566470 NINL -0.36 -5.81 -0.3 1.43e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4423214 0.959 rs12800438 chr11:71171003 G/A cg05163923 chr11:71159392 DHCR7 0.74 11.0 0.52 3.15e-24 Vitamin D levels; LUSC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg04267008 chr7:1944627 MAD1L1 -0.54 -8.16 -0.41 6.68e-15 Bipolar disorder and schizophrenia; LUSC cis rs4919694 0.572 rs7080935 chr10:104929113 C/A cg05855489 chr10:104503620 C10orf26 0.55 6.27 0.32 1.1e-9 Arsenic metabolism; LUSC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg01283332 chr5:1856932 NA -0.33 -6.15 -0.32 2.17e-9 Cardiovascular disease risk factors; LUSC cis rs60154123 0.764 rs1418257 chr1:210452846 G/A cg22029157 chr1:209979665 IRF6 0.55 5.88 0.31 9.91e-9 Coronary artery disease; LUSC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs3733585 0.648 rs67820465 chr4:9975873 A/G cg11266682 chr4:10021025 SLC2A9 -0.51 -9.51 -0.46 3.84e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg20503657 chr10:835505 NA 0.98 14.09 0.61 1.01e-35 Eosinophil percentage of granulocytes; LUSC cis rs7561273 0.586 rs11902756 chr2:24300932 A/G cg06627628 chr2:24431161 ITSN2 -0.51 -6.74 -0.35 6.81e-11 Quantitative traits; LUSC cis rs12541335 0.603 rs9792127 chr8:22180334 G/A cg26039829 chr8:22132926 PIWIL2 0.43 7.79 0.39 8.58e-14 Hypertriglyceridemia; LUSC trans rs9291683 0.510 rs4318649 chr4:10016815 T/C cg26043149 chr18:55253948 FECH 0.48 7.22 0.37 3.5e-12 Bone mineral density; LUSC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg10556349 chr10:835070 NA 0.44 5.67 0.3 3.02e-8 Eosinophil percentage of granulocytes; LUSC cis rs295137 0.725 rs1729413 chr2:201086663 T/G cg23649088 chr2:200775458 C2orf69 0.45 6.69 0.34 9.57e-11 Asthma (bronchodilator response); LUSC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg13628971 chr7:2884303 GNA12 0.46 6.31 0.33 8.74e-10 Height; LUSC cis rs2692947 0.727 rs893173 chr2:96789787 T/C cg22654517 chr2:96458247 NA 0.35 7.04 0.36 1.09e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10992471 0.627 rs10820980 chr9:95253342 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.77 -0.39 9.98e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg01448562 chr3:133502909 NA 0.6 9.64 0.47 1.42e-19 Iron status biomarkers; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25387593 chr11:118927868 HYOU1 0.45 6.58 0.34 1.79e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 8.48 0.42 7.57e-16 Age-related macular degeneration (geographic atrophy); LUSC trans rs9291683 0.588 rs12507330 chr4:10002195 G/A cg26043149 chr18:55253948 FECH 0.5 7.45 0.38 8.11e-13 Bone mineral density; LUSC cis rs1048238 0.506 rs848210 chr1:16259813 A/G cg21385522 chr1:16154831 NA -0.53 -8.1 -0.41 1.03e-14 Systolic blood pressure; LUSC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg04414720 chr1:150670196 GOLPH3L 0.51 7.82 0.39 6.99e-14 Melanoma; LUSC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg22535103 chr8:58192502 C8orf71 -0.75 -7.79 -0.39 8.27e-14 Developmental language disorder (linguistic errors); LUSC cis rs7927771 0.524 rs10742817 chr11:47689343 A/G cg18512352 chr11:47633146 NA -0.28 -5.82 -0.3 1.4e-8 Subjective well-being; LUSC cis rs2573652 1.000 rs7163481 chr15:100516916 C/G cg09918751 chr15:100517450 ADAMTS17 0.41 7.87 0.4 5.14e-14 Height; LUSC cis rs6684514 1.000 rs10908499 chr1:156279176 G/C cg16558208 chr1:156270281 VHLL 0.35 5.67 0.3 3.1e-8 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; LUSC cis rs8028313 0.731 rs4776964 chr15:68016955 T/G cg27219399 chr15:67835830 MAP2K5 0.36 5.82 0.3 1.39e-8 Obesity; LUSC cis rs2227631 0.505 rs6955537 chr7:100759727 A/G cg18465962 chr7:100767262 NA -0.36 -5.87 -0.31 1.06e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09556632 chr1:40839764 SMAP2 -0.51 -6.65 -0.34 1.19e-10 Bipolar disorder and schizophrenia; LUSC cis rs7659604 0.537 rs6815973 chr4:122663430 A/T cg06713675 chr4:122721982 EXOSC9 0.49 7.16 0.36 5.26e-12 Type 2 diabetes; LUSC cis rs28830936 0.625 rs8038764 chr15:41907905 A/C cg17847044 chr15:42102381 MAPKBP1 0.37 9.12 0.45 7.16e-18 Diastolic blood pressure; LUSC cis rs6722750 0.587 rs1881711 chr2:64416880 T/C cg22352474 chr2:64371530 PELI1 -0.54 -7.99 -0.4 2.21e-14 Neuroticism; LUSC trans rs7824557 0.564 rs2572386 chr8:11236975 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.47 -0.33 3.47e-10 Retinal vascular caliber; LUSC cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg02527881 chr3:46936655 PTH1R 0.38 6.89 0.35 2.79e-11 Colorectal cancer; LUSC trans rs6951245 1.000 rs11767527 chr7:1097394 T/C cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2952156 0.883 rs2517960 chr17:37846521 T/C cg20243544 chr17:37824526 PNMT 0.48 6.73 0.35 7.42e-11 Asthma; LUSC cis rs950169 0.922 rs4338765 chr15:84916836 G/T cg17173187 chr15:85201210 NMB 0.37 6.65 0.34 1.19e-10 Schizophrenia; LUSC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg02569458 chr12:86230093 RASSF9 0.52 8.61 0.43 2.94e-16 Major depressive disorder; LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.67 0.67 8.03e-46 Platelet count; LUSC cis rs4988958 0.527 rs6756161 chr2:103048417 C/A cg03938978 chr2:103052716 IL18RAP 0.37 7.06 0.36 9.98e-12 Asthma (childhood onset); LUSC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg08798685 chr6:27730294 NA -0.68 -6.24 -0.32 1.33e-9 Depression; LUSC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg22638593 chr5:131593259 PDLIM4 0.39 5.78 0.3 1.71e-8 Blood metabolite levels; LUSC trans rs7792596 0.861 rs6970279 chr7:94014889 A/C cg25751266 chr3:38495385 LOC100128640;ACVR2B -0.41 -5.96 -0.31 6.52e-9 Intelligence; LUSC cis rs858239 0.601 rs15775 chr7:23164701 C/T cg23682824 chr7:23144976 KLHL7 0.4 5.95 0.31 6.59e-9 Cerebrospinal fluid biomarker levels; LUSC trans rs2262909 0.925 rs404822 chr19:22215967 A/C cg17074339 chr11:11642133 GALNTL4 -0.42 -6.22 -0.32 1.45e-9 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.51 -8.5 -0.42 6.22e-16 Prudent dietary pattern; LUSC cis rs11077998 0.935 rs12185276 chr17:80498997 T/C cg10255544 chr17:80519551 FOXK2 0.41 6.73 0.35 7.32e-11 Reticulocyte fraction of red cells; LUSC cis rs2346177 0.874 rs4953372 chr2:46651624 C/G cg26688816 chr2:46740690 ATP6V1E2 0.5 7.9 0.4 3.99e-14 HDL cholesterol; LUSC cis rs7312933 0.558 rs11181467 chr12:42765250 C/T cg01256987 chr12:42539512 GXYLT1 -0.41 -7.46 -0.38 7.71e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs8072100 0.512 rs9303533 chr17:45386540 A/G cg08085267 chr17:45401833 C17orf57 -0.62 -10.33 -0.49 7e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs4588572 0.644 rs6882191 chr5:77743098 G/A cg11547950 chr5:77652471 NA -0.46 -6.79 -0.35 5.25e-11 Triglycerides; LUSC cis rs9660992 1.000 rs3851296 chr1:205253839 A/C cg21545522 chr1:205238299 TMCC2 0.41 7.72 0.39 1.36e-13 Mean corpuscular volume;Mean platelet volume; LUSC trans rs61931739 0.533 rs4270002 chr12:34313126 G/T cg24313572 chr1:56050060 NA -0.31 -6.32 -0.33 8.32e-10 Morning vs. evening chronotype; LUSC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 8.55 0.42 4.35e-16 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs61931739 0.635 rs10772122 chr12:33964674 A/C cg13010199 chr12:38710504 ALG10B 0.4 6.0 0.31 5.01e-9 Morning vs. evening chronotype; LUSC cis rs6076065 0.723 rs6083100 chr20:23358651 G/A cg11657817 chr20:23433608 CST11 0.42 7.99 0.4 2.19e-14 Facial morphology (factor 15, philtrum width); LUSC cis rs3796619 1.000 rs28620427 chr4:1086247 T/G cg27284194 chr4:1044797 NA 0.52 8.62 0.43 2.77e-16 Recombination rate (males); LUSC trans rs35110281 0.693 rs4819290 chr21:45122713 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.63 10.67 0.5 4.7e-23 Mean corpuscular volume; LUSC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg00149659 chr3:10157352 C3orf10 0.61 8.75 0.43 1.07e-16 Alzheimer's disease; LUSC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg24531977 chr5:56204891 C5orf35 -0.65 -9.75 -0.47 6.24e-20 Coronary artery disease; LUSC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg03517284 chr6:25882590 NA -0.5 -8.41 -0.42 1.22e-15 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg16325326 chr1:53192061 ZYG11B -0.82 -14.17 -0.61 5.19e-36 Monocyte count; LUSC cis rs1371867 0.875 rs1788176 chr8:101332112 A/G cg00191853 chr8:101177733 SPAG1 -0.41 -6.53 -0.34 2.46e-10 Atrioventricular conduction; LUSC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg00343986 chr7:65444356 GUSB -0.44 -6.73 -0.35 7.28e-11 Aortic root size; LUSC cis rs9796 0.674 rs6492978 chr15:41317702 T/C cg18705301 chr15:41695430 NDUFAF1 -0.44 -7.83 -0.39 6.42e-14 Menopause (age at onset); LUSC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg08975724 chr8:8085496 FLJ10661 -0.45 -6.46 -0.33 3.78e-10 Joint mobility (Beighton score); LUSC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg04800585 chr6:26043546 HIST1H2BB -0.4 -6.08 -0.32 3.3e-9 Intelligence (multi-trait analysis); LUSC cis rs10793273 1 rs10793273 chr11:77742595 T/C cg09721595 chr11:77773924 THRSP -0.5 -8.99 -0.44 1.83e-17 Pelvic organ prolapse; LUSC cis rs136211 0.577 rs9610498 chr22:36777739 C/T cg21778268 chr22:36877729 TXN2 -0.41 -6.03 -0.31 4.44e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs1577917 0.629 rs9450285 chr6:86208096 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 6.91 0.35 2.46e-11 Response to antipsychotic treatment; LUSC cis rs7223966 1.000 rs8081541 chr17:61812483 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.08 0.32 3.27e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs12519773 0.526 rs4264926 chr5:92518686 C/T cg18783429 chr5:92414398 NA 0.33 7.22 0.37 3.44e-12 Migraine; LUSC cis rs7043114 0.525 rs2516567 chr9:95187418 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.38 -6.88 -0.35 3.04e-11 Height; LUSC trans rs2243480 1.000 rs36033484 chr7:65390558 T/G cg10756647 chr7:56101905 PSPH 0.89 8.61 0.43 2.86e-16 Diabetic kidney disease; LUSC cis rs1799949 0.965 rs8071278 chr17:41193910 A/T cg01879757 chr17:41196368 BRCA1 -0.48 -7.55 -0.38 4.11e-13 Menopause (age at onset); LUSC cis rs644799 0.544 rs1622515 chr11:95523433 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.66 9.7 0.47 9.03e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7953508 0.711 rs11611927 chr12:93977591 A/G cg18151635 chr12:93972918 NA -0.57 -8.11 -0.41 1e-14 Pubertal anthropometrics; LUSC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg14416269 chr4:6271139 WFS1 0.54 11.38 0.53 1.35e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1008375 0.931 rs7435102 chr4:17571480 C/G cg04450456 chr4:17643702 FAM184B 0.36 5.87 0.31 1.04e-8 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs4680 0.737 rs3810595 chr22:19949644 G/C cg22546130 chr22:19950026 COMT -0.4 -8.65 -0.43 2.19e-16 Blood metabolite levels; LUSC cis rs72781680 0.898 rs72796171 chr2:23942667 G/C cg20701182 chr2:24300061 SF3B14 0.55 5.7 0.3 2.69e-8 Lymphocyte counts; LUSC cis rs977987 0.742 rs12928898 chr16:75462081 G/A cg04384234 chr16:75411784 CFDP1 -0.43 -7.0 -0.36 1.39e-11 Dupuytren's disease; LUSC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg17724175 chr1:150552817 MCL1 -0.49 -8.75 -0.43 1.1e-16 Urate levels; LUSC cis rs868036 1.000 rs1026733 chr15:68095122 G/A cg08079166 chr15:68083412 MAP2K5 0.41 8.49 0.42 6.72e-16 Restless legs syndrome; LUSC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -5.86 -0.31 1.12e-8 Life satisfaction; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00557308 chr15:66274821 MEGF11 0.39 6.04 0.31 4.09e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.34 0.53 1.9e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.46 9.21 0.45 3.61e-18 Hemoglobin concentration; LUSC cis rs7582180 0.629 rs11686649 chr2:100946701 T/C cg14675211 chr2:100938903 LONRF2 0.37 5.71 0.3 2.46e-8 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg05347473 chr6:146136440 FBXO30 -0.52 -8.89 -0.44 3.85e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs2617583 0.967 rs2652510 chr5:1447860 C/T cg07148919 chr5:1466943 LPCAT1 0.41 6.09 0.32 3.08e-9 Breast cancer; LUSC cis rs2832077 0.943 rs2832094 chr21:30165910 G/A cg24692254 chr21:30365293 RNF160 -0.54 -6.86 -0.35 3.31e-11 Cognitive test performance; LUSC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg02569458 chr12:86230093 RASSF9 0.58 9.93 0.48 1.56e-20 Major depressive disorder; LUSC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg05025164 chr4:1340916 KIAA1530 0.42 6.63 0.34 1.32e-10 Obesity-related traits; LUSC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg05347473 chr6:146136440 FBXO30 0.51 8.78 0.43 8.73e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs561341 0.739 rs4795663 chr17:30214542 T/C cg00745463 chr17:30367425 LRRC37B 0.47 6.47 0.33 3.55e-10 Hip circumference adjusted for BMI; LUSC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg15921436 chr17:44337874 NA -0.72 -10.94 -0.51 5.04e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg04111992 chr7:158790115 NA -0.44 -7.03 -0.36 1.17e-11 Facial morphology (factor 20); LUSC trans rs7615952 0.515 rs4267608 chr3:125680500 C/T cg07211511 chr3:129823064 LOC729375 -0.76 -10.06 -0.48 5.58e-21 Blood pressure (smoking interaction); LUSC cis rs12048904 0.541 rs1571046 chr1:101299216 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.59 7.61 0.38 2.81e-13 Multiple sclerosis; LUSC cis rs193541 0.626 rs4629596 chr5:122089108 G/A cg19077854 chr5:122220652 SNX24 0.28 6.31 0.33 8.78e-10 Glucose homeostasis traits; LUSC cis rs7833787 0.929 rs7844317 chr8:18697046 T/A cg17701159 chr8:18705777 PSD3 -0.37 -5.93 -0.31 7.38e-9 Obesity-related traits; LUSC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg20406979 chr6:167373233 NA -0.26 -6.29 -0.33 9.8e-10 Crohn's disease; LUSC cis rs10791323 0.660 rs2156681 chr11:133731644 G/T cg15485101 chr11:133734466 NA 0.38 7.16 0.36 5.15e-12 Childhood ear infection; LUSC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg10802521 chr3:52805072 NEK4 -0.55 -9.0 -0.44 1.75e-17 Electroencephalogram traits; LUSC cis rs62027291 0.654 rs62028181 chr15:77006293 A/G cg26408565 chr15:76604113 ETFA 0.77 7.01 0.36 1.32e-11 Plateletcrit; LUSC cis rs7582720 0.778 rs6719001 chr2:203777903 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.78 8.25 0.41 3.69e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs9527 0.545 rs11191602 chr10:104954219 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.69 0.47 1.01e-19 Arsenic metabolism; LUSC trans rs10016947 1.000 rs28521589 chr4:104252227 G/C cg02356640 chr11:1501973 HCCA2 0.69 6.07 0.32 3.56e-9 Breast cancer; LUSC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg02569458 chr12:86230093 RASSF9 0.48 7.64 0.39 2.37e-13 Major depressive disorder; LUSC cis rs77633900 0.881 rs1875883 chr15:76638231 C/T cg21673338 chr15:77095150 SCAPER -0.7 -6.03 -0.31 4.34e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg00944433 chr1:107599041 PRMT6 -0.33 -5.97 -0.31 6.17e-9 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7582180 0.614 rs6737217 chr2:101006267 T/G cg08017756 chr2:100939284 LONRF2 -0.44 -8.31 -0.41 2.51e-15 Intelligence (multi-trait analysis); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg03633073 chr16:89437518 ANKRD11 -0.36 -5.98 -0.31 5.76e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg06074448 chr4:187884817 NA -0.39 -6.49 -0.33 3.06e-10 Lobe attachment (rater-scored or self-reported); LUSC cis rs10927875 0.619 rs28537253 chr1:16148600 A/C cg22431228 chr1:16359049 CLCNKA 0.35 7.25 0.37 2.84e-12 Dilated cardiomyopathy; LUSC cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.68 -11.65 -0.54 1.5e-26 Total body bone mineral density; LUSC cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg12011299 chr4:100065546 ADH4 0.69 10.72 0.51 3.17e-23 Alcohol dependence; LUSC cis rs10072221 0.836 rs11747990 chr5:75705617 T/C cg03132911 chr5:75698732 IQGAP2 0.37 6.24 0.32 1.29e-9 Mean platelet volume; LUSC cis rs6942756 1.000 rs7780886 chr7:128879347 G/A cg02491457 chr7:128862824 NA -0.53 -7.57 -0.38 3.57e-13 White matter hyperintensity burden; LUSC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg17545662 chr6:170176663 C6orf70 0.51 8.24 0.41 4.01e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs8067354 0.645 rs2645489 chr17:57883371 T/G cg02344993 chr17:57696989 CLTC 0.49 7.28 0.37 2.38e-12 Hemoglobin concentration; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14885145 chr10:104262292 SUFU;ACTR1A -0.46 -6.93 -0.35 2.12e-11 Hepatitis; LUSC cis rs5769765 1.000 rs5770728 chr22:50259984 G/A cg02269571 chr22:50332266 NA 0.59 8.73 0.43 1.21e-16 Schizophrenia; LUSC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg13206674 chr6:150067644 NUP43 0.61 9.66 0.47 1.27e-19 Lung cancer; LUSC cis rs4654899 0.802 rs4654724 chr1:21177210 C/T cg02927042 chr1:21476669 EIF4G3 -0.37 -5.78 -0.3 1.75e-8 Superior frontal gyrus grey matter volume; LUSC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg19318889 chr4:1322082 MAEA 0.48 7.88 0.4 4.54e-14 Obesity-related traits; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg08888203 chr3:10149979 C3orf24 0.59 8.11 0.41 9.88e-15 Alzheimer's disease; LUSC cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg12011299 chr4:100065546 ADH4 0.7 10.4 0.49 3.93e-22 Smoking initiation; LUSC cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg01884057 chr2:25150051 NA -0.47 -11.47 -0.53 6.9e-26 Body mass index in non-asthmatics; LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg16606324 chr3:10149918 C3orf24 0.68 10.1 0.48 4.33e-21 Alzheimer's disease; LUSC cis rs10733682 1.000 rs10733682 chr9:129460914 C/T cg00232160 chr9:129468157 NA 0.32 5.82 0.3 1.39e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1044826 0.692 rs188421 chr3:139234066 A/C cg00490450 chr3:139108681 COPB2 -0.45 -6.93 -0.35 2.2e-11 Obesity-related traits; LUSC cis rs3741404 0.574 rs616563 chr11:63877501 G/C cg18225595 chr11:63971243 STIP1 0.44 6.98 0.36 1.64e-11 Platelet count; LUSC cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg23711669 chr6:146136114 FBXO30 0.78 14.05 0.61 1.54e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs17253792 0.822 rs75509578 chr14:56133493 G/A cg01858014 chr14:56050164 KTN1 -0.78 -6.81 -0.35 4.62e-11 Putamen volume; LUSC cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg01884057 chr2:25150051 NA 0.45 10.5 0.5 1.77e-22 Body mass index; LUSC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.59 9.21 0.45 3.77e-18 Total body bone mineral density; LUSC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg27398817 chr8:82754497 SNX16 -0.46 -6.2 -0.32 1.7e-9 Diastolic blood pressure; LUSC cis rs1784581 0.546 rs1954917 chr6:162447490 C/T cg17173639 chr6:162384350 PARK2 0.59 10.2 0.49 1.89e-21 Itch intensity from mosquito bite; LUSC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg27398817 chr8:82754497 SNX16 0.66 8.41 0.42 1.18e-15 Diastolic blood pressure; LUSC trans rs800082 1.000 rs12637885 chr3:144291254 G/T cg24215973 chr2:240111563 HDAC4 -0.46 -6.92 -0.35 2.36e-11 Smoking behavior; LUSC cis rs11025559 0.812 rs10833336 chr11:20514288 C/G cg19653624 chr11:20408972 PRMT3 -0.63 -8.13 -0.41 8.53e-15 Pursuit maintenance gain; LUSC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.83 0.35 3.97e-11 Tonsillectomy; LUSC cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC cis rs1775715 0.870 rs1755080 chr10:32255195 G/A cg18675610 chr10:32216311 ARHGAP12 0.29 6.06 0.31 3.63e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9814567 0.964 rs4539979 chr3:134287597 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.55 -0.6 1.2e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12908161 1.000 rs12910012 chr15:85298662 T/C cg17507749 chr15:85114479 UBE2QP1 0.54 6.66 0.34 1.15e-10 Schizophrenia; LUSC cis rs12472274 0.941 rs12616232 chr2:239080093 C/T cg17459225 chr2:239074497 NA 0.63 9.69 0.47 1.03e-19 Phospholipid levels (plasma); LUSC cis rs11123610 0.520 rs13409381 chr2:3722579 A/G cg10645314 chr2:3704589 ALLC -0.49 -7.33 -0.37 1.75e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs892961 0.932 rs67719929 chr17:75412605 G/A cg05865280 chr17:75406074 SEPT9 0.46 9.62 0.47 1.67e-19 Airflow obstruction; LUSC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg12963246 chr6:28129442 ZNF389 0.4 6.18 0.32 1.84e-9 Parkinson's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19058453 chr19:9879420 ZNF846 -0.51 -6.08 -0.32 3.22e-9 Bipolar disorder and schizophrenia; LUSC cis rs9469578 1.000 rs6942022 chr6:33710284 C/T cg18708504 chr6:33715942 IP6K3 0.72 9.2 0.45 4.1e-18 Phosphorus levels; LUSC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 14.5 0.62 2.75e-37 Platelet count; LUSC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg15147215 chr3:52552868 STAB1 -0.35 -7.03 -0.36 1.18e-11 Cognitive function; LUSC cis rs4664308 0.875 rs7593593 chr2:160933811 C/T cg03641300 chr2:160917029 PLA2R1 -0.68 -11.62 -0.54 1.97e-26 Idiopathic membranous nephropathy; LUSC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg13012494 chr21:47604986 C21orf56 -0.4 -5.7 -0.3 2.58e-8 Testicular germ cell tumor; LUSC cis rs877282 0.945 rs11253398 chr10:790012 T/C cg13775593 chr10:823151 NA 0.3 5.71 0.3 2.46e-8 Uric acid levels; LUSC cis rs2677744 0.626 rs2001216 chr15:91498130 T/C cg23684204 chr15:91497937 RCCD1 0.58 8.01 0.4 1.89e-14 Attention deficit hyperactivity disorder; LUSC cis rs11711311 0.955 rs11715350 chr3:113418376 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.52 0.34 2.64e-10 IgG glycosylation; LUSC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg15556689 chr8:8085844 FLJ10661 -0.65 -9.62 -0.47 1.71e-19 Neuroticism; LUSC cis rs9633740 0.947 rs7096909 chr10:82284512 A/T cg01528321 chr10:82214614 TSPAN14 -0.95 -10.8 -0.51 1.56e-23 Post bronchodilator FEV1; LUSC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg26958806 chr6:27640298 NA 0.63 5.65 0.3 3.45e-8 Depression; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg11639397 chr19:46010716 VASP 0.42 6.33 0.33 8e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg12751644 chr20:60527061 NA -0.33 -6.14 -0.32 2.4e-9 Body mass index; LUSC cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg18252515 chr7:66147081 NA -1.19 -12.75 -0.57 1.35e-30 Diabetic kidney disease; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg13047869 chr3:10149882 C3orf24 0.6 8.18 0.41 5.93e-15 Alzheimer's disease; LUSC trans rs61931739 0.534 rs2636082 chr12:34061848 T/A cg26384229 chr12:38710491 ALG10B 0.71 10.98 0.51 3.59e-24 Morning vs. evening chronotype; LUSC cis rs61990749 0.597 rs10136053 chr14:78155205 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -6.42 -0.33 4.6e-10 Fibroblast growth factor basic levels; LUSC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg08847533 chr14:75593920 NEK9 -0.82 -13.87 -0.6 7.48e-35 Height; LUSC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg10523679 chr1:76189770 ACADM 0.84 11.18 0.52 7.49e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg04369109 chr6:150039330 LATS1 -0.51 -7.22 -0.37 3.59e-12 Lung cancer; LUSC cis rs4853012 0.838 rs2177707 chr2:74356850 A/G cg01017244 chr2:74357527 NA 0.73 14.16 0.61 5.37e-36 Gestational age at birth (maternal effect); LUSC cis rs2734839 0.537 rs1554929 chr11:113278764 C/T cg14159747 chr11:113255604 NA 0.27 7.14 0.36 5.76e-12 Information processing speed; LUSC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg26314531 chr2:26401878 FAM59B -0.69 -9.21 -0.45 3.67e-18 Gut microbiome composition (summer); LUSC cis rs9309711 0.621 rs11127428 chr2:3471146 T/C cg08493051 chr2:3487164 NA -0.51 -7.61 -0.38 2.92e-13 Neurofibrillary tangles; LUSC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.05 22.14 0.77 1.81e-67 Height; LUSC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg22535103 chr8:58192502 C8orf71 -0.75 -7.79 -0.39 8.27e-14 Developmental language disorder (linguistic errors); LUSC trans rs2243480 1.000 rs778729 chr7:65824419 T/C cg10756647 chr7:56101905 PSPH 0.85 8.37 0.42 1.55e-15 Diabetic kidney disease; LUSC cis rs7180079 1.000 rs7180079 chr15:64629873 A/G cg08069370 chr15:64387884 SNX1 0.57 6.28 0.32 1.05e-9 Monocyte count; LUSC cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg18512352 chr11:47633146 NA 0.47 9.41 0.46 8.08e-19 Subjective well-being; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27614445 chr3:179041226 ZNF639 0.45 7.53 0.38 4.87e-13 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.11 -0.48 3.97e-21 Obesity-related traits; LUSC cis rs2456568 0.548 rs4753113 chr11:93660974 G/A cg17595323 chr11:93583763 C11orf90 -0.31 -5.67 -0.3 3.09e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs1559088 0.948 rs12610266 chr19:33581237 C/G cg03563238 chr19:33554763 RHPN2 0.4 6.33 0.33 7.84e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs13242816 0.881 rs35037267 chr7:116117587 A/T cg16553024 chr7:116138462 CAV2 -0.52 -5.69 -0.3 2.81e-8 P wave duration; LUSC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg03676636 chr4:99064102 C4orf37 0.36 7.65 0.39 2.12e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg24060327 chr5:131705240 SLC22A5 -0.67 -11.6 -0.54 2.19e-26 Breast cancer; LUSC cis rs7568458 0.837 rs12714145 chr2:85787341 C/T cg23752985 chr2:85803571 VAMP8 0.34 7.45 0.38 7.85e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg05890377 chr2:74357713 NA 0.72 13.55 0.6 1.27e-33 Gestational age at birth (maternal effect); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01435220 chr17:42634155 FZD2 -0.47 -6.13 -0.32 2.55e-9 Hepatitis; LUSC cis rs9747201 0.962 rs11656153 chr17:80072950 G/A cg17462356 chr17:80056334 FASN 0.47 6.04 0.31 4.11e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4776059 1.000 rs12915981 chr15:52901433 C/T cg25063058 chr15:52860530 ARPP19 0.43 6.07 0.32 3.43e-9 Schizophrenia; LUSC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg06481639 chr22:41940642 POLR3H -0.53 -6.19 -0.32 1.74e-9 Vitiligo; LUSC cis rs10949662 1.000 rs10949662 chr7:157534105 A/G cg05731713 chr7:157510257 PTPRN2 -0.43 -7.83 -0.39 6.47e-14 Intelligence (multi-trait analysis); LUSC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg22823121 chr1:150693482 HORMAD1 0.49 7.11 0.36 6.94e-12 Melanoma; LUSC cis rs7267979 1.000 rs6107047 chr20:25442097 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.22 0.71 5.32e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9807989 0.811 rs11688568 chr2:102969949 C/T cg09003973 chr2:102972529 NA 0.44 6.04 0.31 4.15e-9 Asthma; LUSC cis rs2051773 0.567 rs12293395 chr11:17047661 C/G cg15084286 chr11:17036142 PLEKHA7 -0.45 -5.71 -0.3 2.45e-8 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; LUSC cis rs11122272 0.735 rs2491403 chr1:231511185 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg08109568 chr15:31115862 NA -0.72 -10.68 -0.5 4.06e-23 Huntington's disease progression; LUSC cis rs2404602 0.669 rs12438540 chr15:76943213 C/G cg26408565 chr15:76604113 ETFA -0.47 -7.48 -0.38 6.44e-13 Blood metabolite levels; LUSC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg23205692 chr1:25664452 TMEM50A -0.41 -6.06 -0.31 3.76e-9 Erythrocyte sedimentation rate; LUSC cis rs7809950 1.000 rs2237676 chr7:107198079 C/A cg23024343 chr7:107201750 COG5 -0.56 -8.88 -0.44 4.33e-17 Coronary artery disease; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg22194305 chr4:2264032 MXD4 0.4 6.35 0.33 6.99e-10 Schizophrenia; LUSC cis rs9902453 0.845 rs2259855 chr17:28097860 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -9.29 -0.45 1.99e-18 Coffee consumption (cups per day); LUSC cis rs12477438 0.765 rs7605218 chr2:99593080 G/T cg15544633 chr2:99771531 LIPT1;TSGA10 -0.86 -12.68 -0.57 2.41e-30 Chronic sinus infection; LUSC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg11752832 chr7:134001865 SLC35B4 0.59 9.24 0.45 2.86e-18 Mean platelet volume; LUSC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg24642439 chr20:33292090 TP53INP2 -0.53 -8.16 -0.41 6.77e-15 Glomerular filtration rate (creatinine); LUSC cis rs8017423 0.904 rs11623741 chr14:90804474 C/T cg04374321 chr14:90722782 PSMC1 0.65 9.96 0.48 1.22e-20 Mortality in heart failure; LUSC cis rs7809950 0.678 rs4730235 chr7:107022506 T/C cg23024343 chr7:107201750 COG5 -0.68 -9.97 -0.48 1.13e-20 Coronary artery disease; LUSC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg02569458 chr12:86230093 RASSF9 0.48 7.66 0.39 2.03e-13 Major depressive disorder; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10507121 chr5:118324332 DTWD2 0.5 7.24 0.37 3.04e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg16339924 chr4:17578868 LAP3 0.58 8.68 0.43 1.74e-16 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg23205692 chr1:25664452 TMEM50A -0.44 -6.59 -0.34 1.72e-10 Erythrocyte sedimentation rate; LUSC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg06640241 chr16:89574553 SPG7 0.74 12.2 0.56 1.45e-28 Multiple myeloma (IgH translocation); LUSC trans rs34421088 0.576 rs2572436 chr8:11099209 C/T cg15556689 chr8:8085844 FLJ10661 -0.44 -6.32 -0.33 8.23e-10 Neuroticism; LUSC trans rs60843830 0.964 rs17713879 chr2:254215 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.62 9.81 0.47 3.97e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1023500 0.551 rs61665536 chr22:42512613 A/G cg15557168 chr22:42548783 NA 0.46 7.07 0.36 9.14e-12 Schizophrenia; LUSC cis rs9814567 0.727 rs4437193 chr3:134352344 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.79 -12.94 -0.58 2.45e-31 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg16339924 chr4:17578868 LAP3 0.54 8.15 0.41 7.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg22823121 chr1:150693482 HORMAD1 0.48 6.98 0.36 1.63e-11 Melanoma; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg22963979 chr7:1858916 MAD1L1 -0.61 -9.72 -0.47 8.03e-20 Bipolar disorder and schizophrenia; LUSC cis rs4959270 0.780 rs4339511 chr6:451895 T/C cg09757644 chr6:447497 NA 0.28 5.88 0.31 9.96e-9 Limited cutaneous systemic scleroderma; LUSC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg11062466 chr8:58055876 NA 0.68 8.11 0.41 9.88e-15 Developmental language disorder (linguistic errors); LUSC trans rs12200782 1.000 rs3927423 chr6:26393487 C/T cg11837749 chr1:55047332 ACOT11 0.59 6.15 0.32 2.19e-9 Small cell lung carcinoma; LUSC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg04944784 chr2:26401820 FAM59B -0.67 -9.44 -0.46 6.54e-19 Gut microbiome composition (summer); LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg11905131 chr22:24372483 LOC391322 -0.58 -9.71 -0.47 8.4e-20 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs367943 0.712 rs4331889 chr5:112679795 C/T cg12552261 chr5:112820674 MCC 0.37 6.15 0.32 2.18e-9 Type 2 diabetes; LUSC cis rs17253792 0.822 rs17253723 chr14:56154015 A/G cg01858014 chr14:56050164 KTN1 -0.82 -6.77 -0.35 5.9e-11 Putamen volume; LUSC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg05025164 chr4:1340916 KIAA1530 0.41 6.12 0.32 2.59e-9 Obesity-related traits; LUSC trans rs34421088 0.532 rs1545073 chr8:11167700 C/T cg06636001 chr8:8085503 FLJ10661 0.45 6.83 0.35 4.11e-11 Neuroticism; LUSC cis rs8114671 0.562 rs959829 chr20:33346047 T/C cg24642439 chr20:33292090 TP53INP2 -0.5 -7.32 -0.37 1.87e-12 Height; LUSC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg11189052 chr15:85197271 WDR73 0.47 5.65 0.3 3.44e-8 Schizophrenia; LUSC cis rs17818399 0.749 rs4142759 chr2:46783890 A/G cg02822958 chr2:46747628 ATP6V1E2 0.41 6.11 0.32 2.77e-9 Height; LUSC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg02753203 chr1:228287806 NA -0.66 -11.04 -0.52 2.35e-24 Diastolic blood pressure; LUSC cis rs72634258 0.945 rs12745223 chr1:8094978 C/T cg26816564 chr1:7831052 VAMP3 0.51 6.28 0.33 1.02e-9 Inflammatory bowel disease; LUSC cis rs7727544 0.582 rs7703009 chr5:131552385 C/G cg14196790 chr5:131705035 SLC22A5 0.45 7.46 0.38 7.67e-13 Blood metabolite levels; LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg05552183 chr6:42928497 GNMT 0.47 7.97 0.4 2.48e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg23303369 chr20:44641161 MMP9 0.35 6.09 0.32 3.04e-9 Intelligence (multi-trait analysis); LUSC cis rs8030485 0.536 rs1915724 chr15:79441027 A/G cg17916960 chr15:79447300 NA 0.39 7.24 0.37 3.09e-12 Left ventricle wall thickness; LUSC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg02574844 chr11:5959923 NA -0.41 -5.74 -0.3 2.15e-8 DNA methylation (variation); LUSC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg17366294 chr4:99064904 C4orf37 0.58 10.3 0.49 8.56e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg21724239 chr8:58056113 NA 0.55 6.61 0.34 1.48e-10 Developmental language disorder (linguistic errors); LUSC cis rs55871839 0.643 rs10105665 chr8:59799367 A/G cg07426533 chr8:59803705 TOX -0.36 -5.69 -0.3 2.82e-8 Pneumonia; LUSC cis rs753778 0.667 rs10103731 chr8:142206068 C/T cg18755752 chr8:142205143 DENND3 -0.78 -13.83 -0.6 1.08e-34 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC trans rs17685 0.725 rs4476928 chr7:75642107 C/A cg19862616 chr7:65841803 NCRNA00174 -1.13 -19.91 -0.74 1.04e-58 Coffee consumption;Coffee consumption (cups per day); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21552528 chr15:64443755 SNX22 -0.42 -6.13 -0.32 2.44e-9 Electrocardiographic conduction measures; LUSC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg00484396 chr16:3507460 NAT15 0.48 7.07 0.36 9.23e-12 Body mass index (adult); LUSC cis rs7824557 0.564 rs12547100 chr8:11242632 G/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.81 -0.3 1.44e-8 Retinal vascular caliber; LUSC cis rs3750965 1.000 rs7937006 chr11:68843932 C/T cg06818126 chr11:68850279 TPCN2 -0.47 -6.89 -0.35 2.78e-11 Hair color; LUSC cis rs34375054 0.525 rs1080910 chr12:125608492 T/C cg09839279 chr12:125627357 AACS -0.33 -6.03 -0.31 4.31e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs911555 0.755 rs8010247 chr14:103933556 A/G cg12935359 chr14:103987150 CKB 0.67 10.87 0.51 9.08e-24 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg07606381 chr6:8435919 SLC35B3 0.73 12.17 0.55 1.93e-28 Motion sickness; LUSC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.2e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.89 -0.31 9.55e-9 Platelet count; LUSC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg21724239 chr8:58056113 NA 0.82 9.77 0.47 5.51e-20 Developmental language disorder (linguistic errors); LUSC cis rs5769765 0.954 rs5769762 chr22:50264042 G/A cg04121214 chr22:50244548 NA -0.34 -5.74 -0.3 2.14e-8 Schizophrenia; LUSC cis rs854765 0.583 rs9908832 chr17:17871068 C/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.49 -0.42 6.82e-16 Total body bone mineral density; LUSC cis rs1348850 0.651 rs4893931 chr2:178228212 T/C cg22681709 chr2:178499509 PDE11A -0.34 -6.3 -0.33 9.46e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs11122272 0.735 rs11122280 chr1:231519816 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.66 -0.47 1.26e-19 Hemoglobin concentration; LUSC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg13939156 chr17:80058883 NA 0.34 6.53 0.34 2.42e-10 Life satisfaction; LUSC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.7 0.47 9.08e-20 Bipolar disorder; LUSC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg16393715 chr7:1948819 MAD1L1 0.35 6.09 0.32 3.17e-9 Bipolar disorder and schizophrenia; LUSC trans rs1927790 0.697 rs61966875 chr13:96936525 C/A cg03198741 chr6:1003969 LOC285768 -0.4 -5.96 -0.31 6.23e-9 Body mass index; LUSC cis rs500891 0.504 rs2152181 chr6:84170615 C/G cg08257003 chr6:84140564 ME1 0.35 8.67 0.43 1.87e-16 Platelet-derived growth factor BB levels; LUSC cis rs11048434 0.736 rs11048344 chr12:9122609 G/C cg23795048 chr12:9217529 LOC144571 0.34 5.85 0.31 1.15e-8 Sjögren's syndrome; LUSC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs9399135 0.844 rs13209789 chr6:135367916 A/G cg24558204 chr6:135376177 HBS1L 0.58 9.03 0.44 1.38e-17 Red blood cell count; LUSC cis rs11792861 0.926 rs72607174 chr9:111899132 A/T cg13535736 chr9:111863775 C9orf5 -0.41 -6.85 -0.35 3.66e-11 Menarche (age at onset); LUSC cis rs9300255 0.602 rs6488864 chr12:123618362 G/C cg13010344 chr12:123464640 ARL6IP4 -0.49 -6.06 -0.31 3.72e-9 Neutrophil percentage of white cells; LUSC cis rs10782582 0.593 rs11589276 chr1:76105545 G/A cg10523679 chr1:76189770 ACADM -0.49 -7.25 -0.37 2.94e-12 Daytime sleep phenotypes; LUSC cis rs9341808 0.559 rs7762895 chr6:81061431 C/T cg08355045 chr6:80787529 NA 0.44 7.41 0.38 1.08e-12 Sitting height ratio; LUSC cis rs2074585 0.583 rs28406958 chr15:91069364 C/A cg10434728 chr15:90938212 IQGAP1 -0.35 -6.44 -0.33 4.17e-10 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 7.87 0.4 5.03e-14 Schizophrenia; LUSC cis rs17270561 0.609 rs4711096 chr6:25727054 A/G cg16482183 chr6:26056742 HIST1H1C 0.65 8.99 0.44 1.89e-17 Iron status biomarkers; LUSC cis rs765787 0.530 rs11070444 chr15:45513121 T/C cg25801113 chr15:45476975 SHF -0.34 -6.71 -0.34 8.19e-11 Uric acid levels; LUSC cis rs7909074 0.509 rs2183994 chr10:45389940 T/C cg05187965 chr10:45406764 TMEM72 -0.29 -5.81 -0.3 1.49e-8 Mean corpuscular volume; LUSC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg07636037 chr3:49044803 WDR6 0.43 6.26 0.32 1.21e-9 Resting heart rate; LUSC cis rs7180079 1.000 rs8028184 chr15:64515543 G/A cg08069370 chr15:64387884 SNX1 -0.54 -5.82 -0.3 1.39e-8 Monocyte count; LUSC cis rs6547741 1.000 rs10165098 chr2:27796526 C/T cg12559939 chr2:27858050 GPN1 0.4 6.32 0.33 8.4e-10 Oral cavity cancer; LUSC cis rs11676348 0.712 rs11687434 chr2:218945143 A/G cg06547715 chr2:218990976 CXCR2 0.31 5.95 0.31 6.68e-9 Ulcerative colitis; LUSC cis rs7538876 0.935 rs1408420 chr1:17754815 A/G cg07965774 chr1:17746286 RCC2 -0.32 -5.96 -0.31 6.55e-9 Basal cell carcinoma; LUSC cis rs5750830 0.594 rs6001568 chr22:39775786 G/A cg01416388 chr22:39784598 NA -0.45 -7.45 -0.38 8.29e-13 Intelligence (multi-trait analysis); LUSC cis rs4889911 0.544 rs2650254 chr17:77833655 A/G cg00646381 chr17:77835854 NA 0.56 8.74 0.43 1.19e-16 Electroencephalogram traits; LUSC cis rs6964587 1.000 rs57816416 chr7:91736078 A/C cg01689657 chr7:91764605 CYP51A1 0.35 6.3 0.33 9.48e-10 Breast cancer; LUSC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg19318889 chr4:1322082 MAEA -0.53 -8.75 -0.43 1.09e-16 Obesity-related traits; LUSC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 0.48 7.04 0.36 1.1e-11 Schizophrenia; LUSC cis rs8133932 0.654 rs375254 chr21:47337151 T/A cg14185626 chr21:47401492 COL6A1 -0.45 -5.74 -0.3 2.09e-8 Schizophrenia; LUSC cis rs7827545 1.000 rs7008121 chr8:135565904 T/C cg17885191 chr8:135476712 NA 0.57 8.45 0.42 8.93e-16 Hypertension (SNP x SNP interaction); LUSC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg15147215 chr3:52552868 STAB1 0.32 6.49 0.33 3.11e-10 Bipolar disorder; LUSC cis rs73206853 0.764 rs28840785 chr12:110844920 C/G cg12870014 chr12:110450643 ANKRD13A 0.68 7.49 0.38 6.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6840360 1.000 rs7669977 chr4:152677527 T/C cg22705602 chr4:152727874 NA -0.27 -5.75 -0.3 2.01e-8 Intelligence (multi-trait analysis); LUSC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg11766577 chr21:47581405 C21orf56 -0.46 -6.93 -0.35 2.22e-11 Testicular germ cell tumor; LUSC cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.19 0.37 4.33e-12 Motion sickness; LUSC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.01e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs656319 0.513 rs17746245 chr8:9981686 A/C cg27411982 chr8:10470053 RP1L1 0.38 5.64 0.3 3.54e-8 Myopia (pathological); LUSC cis rs6121246 0.633 rs6060986 chr20:30426297 G/A cg18721089 chr20:30220636 NA -0.32 -5.9 -0.31 8.73e-9 Mean corpuscular hemoglobin; LUSC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg16606324 chr3:10149918 C3orf24 0.58 8.23 0.41 4.27e-15 Alzheimer's disease; LUSC cis rs9467711 0.606 rs9393712 chr6:26371000 G/C cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg02503808 chr4:7069936 GRPEL1 -1.06 -11.76 -0.54 5.83e-27 Monocyte percentage of white cells; LUSC cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg14061069 chr19:46274453 DMPK -0.54 -9.2 -0.45 4.05e-18 Coronary artery disease; LUSC cis rs17824933 0.806 rs11230565 chr11:60776711 A/G cg16817237 chr11:60793675 NA 0.39 6.09 0.32 3.16e-9 Multiple sclerosis; LUSC cis rs4660306 1.000 rs6429569 chr1:46001330 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.41 -6.62 -0.34 1.42e-10 Homocysteine levels; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.6 0.54 2.33e-26 Prudent dietary pattern; LUSC cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg22676075 chr6:135203613 NA 0.59 9.24 0.45 2.94e-18 Red blood cell count; LUSC cis rs250677 0.652 rs250670 chr5:148446646 G/T cg18129178 chr5:148520854 ABLIM3 -0.69 -10.62 -0.5 6.72e-23 Breast cancer; LUSC cis rs977987 0.800 rs12922951 chr16:75355096 C/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.71 -0.34 8.56e-11 Dupuytren's disease; LUSC cis rs4820539 1.000 rs5759598 chr22:23480962 T/G cg21100191 chr22:23484243 RTDR1 0.87 14.61 0.62 1.05e-37 Bone mineral density; LUSC cis rs7474896 0.537 rs2505255 chr10:38359642 C/A cg25427524 chr10:38739819 LOC399744 -0.46 -6.33 -0.33 8.07e-10 Obesity (extreme); LUSC cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.28e-30 Motion sickness; LUSC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.83 0.3 1.27e-8 Red cell distribution width;Reticulocyte count; LUSC cis rs734999 0.545 rs10752748 chr1:2544640 G/A cg18932078 chr1:2524107 MMEL1 0.31 6.86 0.35 3.42e-11 Ulcerative colitis; LUSC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg05340658 chr4:99064831 C4orf37 0.67 11.4 0.53 1.15e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg06191203 chr2:152266755 RIF1 -0.53 -7.52 -0.38 5.11e-13 Lung cancer; LUSC trans rs61931739 0.890 rs814663 chr12:34106338 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.85 0.35 3.56e-11 Morning vs. evening chronotype; LUSC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg12564285 chr5:131593104 PDLIM4 0.46 8.27 0.41 3.17e-15 Breast cancer; LUSC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg14784868 chr12:69753453 YEATS4 0.62 8.22 0.41 4.53e-15 Response to diuretic therapy; LUSC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg20701182 chr2:24300061 SF3B14 0.88 11.18 0.52 7.08e-25 Lymphocyte counts; LUSC cis rs950169 0.686 rs12906474 chr15:85109237 A/G cg17507749 chr15:85114479 UBE2QP1 0.7 9.24 0.45 3.03e-18 Schizophrenia; LUSC cis rs2463822 0.688 rs7121684 chr11:62162389 T/C cg06239285 chr11:62104954 ASRGL1 -0.96 -10.25 -0.49 1.29e-21 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs10435719 0.780 rs9692662 chr8:11789863 C/T cg14343924 chr8:8086146 FLJ10661 0.44 6.04 0.31 4.1e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2948294 0.588 rs12544596 chr8:8116346 A/T cg06636001 chr8:8085503 FLJ10661 0.75 10.52 0.5 1.54e-22 Red cell distribution width; LUSC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg12463550 chr7:65579703 CRCP -0.44 -6.27 -0.32 1.11e-9 Aortic root size; LUSC cis rs3809566 1.000 rs4775610 chr15:63332057 C/T cg05507819 chr15:63340323 TPM1 -0.64 -8.92 -0.44 3.14e-17 Platelet count; LUSC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg17724175 chr1:150552817 MCL1 0.33 5.66 0.3 3.28e-8 Melanoma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09312254 chr12:112450979 ERP29;TMEM116 -0.4 -6.01 -0.31 4.82e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7189233 0.531 rs1074182 chr16:53471357 T/G cg09728985 chr16:53543985 NA -0.31 -5.8 -0.3 1.55e-8 Intelligence (multi-trait analysis); LUSC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg19717773 chr7:2847554 GNA12 -0.37 -6.19 -0.32 1.75e-9 Height; LUSC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg22823121 chr1:150693482 HORMAD1 0.49 7.28 0.37 2.48e-12 Melanoma; LUSC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.13 -0.36 6.22e-12 Major depressive disorder; LUSC cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.85 -0.35 3.57e-11 Monocyte percentage of white cells; LUSC cis rs6500395 0.708 rs9930644 chr16:48555929 G/C cg04672837 chr16:48644449 N4BP1 0.42 6.12 0.32 2.62e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg19077165 chr18:44547161 KATNAL2 -0.37 -5.69 -0.3 2.8e-8 Personality dimensions; LUSC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg24881330 chr22:46731750 TRMU 0.82 7.77 0.39 9.61e-14 LDL cholesterol;Cholesterol, total; LUSC cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg05985134 chr18:33552581 C18orf21 0.53 7.26 0.37 2.74e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs6066835 1.000 rs6125428 chr20:47292823 C/G cg18078177 chr20:47281410 PREX1 0.77 5.94 0.31 7.31e-9 Multiple myeloma; LUSC cis rs778371 0.676 rs11688166 chr2:233566210 A/G cg08000102 chr2:233561755 GIGYF2 0.83 13.04 0.58 1.07e-31 Schizophrenia; LUSC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg14668632 chr7:2872130 GNA12 -0.41 -6.31 -0.33 8.77e-10 Height; LUSC cis rs3859192 0.599 rs34933056 chr17:38162983 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.71 12.47 0.56 1.41e-29 White blood cell count; LUSC cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.63 9.88 0.48 2.24e-20 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs7666738 0.570 rs10032272 chr4:99095601 T/C cg17366294 chr4:99064904 C4orf37 0.52 9.0 0.44 1.7e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs16957304 1.000 rs16957304 chr16:67334969 C/T cg01866162 chr16:67596514 CTCF -0.66 -5.68 -0.3 2.97e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs8048589 0.577 rs8055516 chr16:12180198 A/T cg02910054 chr16:12241554 SNX29 0.38 5.73 0.3 2.22e-8 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg07701084 chr6:150067640 NUP43 0.54 8.15 0.41 7.58e-15 Lung cancer; LUSC cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg05738196 chr6:26577821 NA -0.8 -14.96 -0.63 4.5e-39 Intelligence (multi-trait analysis); LUSC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg11764359 chr7:65958608 NA 0.68 10.89 0.51 7.59e-24 Aortic root size; LUSC cis rs1808579 0.904 rs1652343 chr18:21131929 T/C cg14672496 chr18:21087552 C18orf8 0.37 6.55 0.34 2.16e-10 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); LUSC cis rs4363385 0.747 rs10788850 chr1:152963932 A/T cg00922841 chr1:152955080 SPRR1A -0.42 -7.29 -0.37 2.26e-12 Inflammatory skin disease; LUSC cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg15103426 chr22:29168792 CCDC117 0.45 5.74 0.3 2.1e-8 Lymphocyte counts; LUSC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg22535103 chr8:58192502 C8orf71 -0.71 -8.95 -0.44 2.5e-17 Developmental language disorder (linguistic errors); LUSC cis rs9549367 0.789 rs3794422 chr13:113893729 G/A cg18105134 chr13:113819100 PROZ -0.68 -9.63 -0.47 1.59e-19 Platelet distribution width; LUSC cis rs6542838 0.641 rs6741166 chr2:99534926 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.48 -6.56 -0.34 2.03e-10 Fear of minor pain; LUSC trans rs1814175 0.645 rs28839231 chr11:50044292 G/T cg15704280 chr7:45808275 SEPT13 -1.03 -19.56 -0.73 2.54e-57 Height; LUSC cis rs7208859 0.673 rs9907197 chr17:29018263 C/T cg13385521 chr17:29058706 SUZ12P 0.58 5.98 0.31 5.68e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs559928 0.606 rs78038516 chr11:63978067 C/G cg05555928 chr11:63887634 MACROD1 -0.45 -5.78 -0.3 1.74e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg03806693 chr22:41940476 POLR3H 1.01 14.57 0.62 1.49e-37 Vitiligo; LUSC cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg07606381 chr6:8435919 SLC35B3 0.74 12.49 0.56 1.26e-29 Motion sickness; LUSC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg19920283 chr7:105172520 RINT1 0.57 6.19 0.32 1.78e-9 Bipolar disorder (body mass index interaction); LUSC cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg00677455 chr12:58241039 CTDSP2 0.49 7.28 0.37 2.45e-12 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -7.38 -0.37 1.25e-12 Developmental language disorder (linguistic errors); LUSC cis rs738322 0.967 rs133021 chr22:38573338 T/C cg17652424 chr22:38574118 PLA2G6 -0.31 -6.66 -0.34 1.1e-10 Cutaneous nevi; LUSC cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg06550200 chr5:1325588 CLPTM1L -0.67 -11.68 -0.54 1.17e-26 Lung cancer; LUSC cis rs9527 0.544 rs1572578 chr10:104822431 C/G cg23093090 chr10:104574429 C10orf26 -0.36 -6.62 -0.34 1.42e-10 Arsenic metabolism; LUSC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg08847533 chr14:75593920 NEK9 -0.81 -13.98 -0.61 2.78e-35 Height; LUSC cis rs2204008 0.546 rs11519978 chr12:37998170 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.86 0.51 9.62e-24 Bladder cancer; LUSC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg13206674 chr6:150067644 NUP43 0.6 9.63 0.47 1.59e-19 Lung cancer; LUSC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg17724175 chr1:150552817 MCL1 0.37 6.79 0.35 5.02e-11 Tonsillectomy; LUSC cis rs4921915 0.598 rs4646243 chr8:18247609 T/C cg18736775 chr8:18248649 NAT2 -0.56 -6.13 -0.32 2.5e-9 Iron status biomarkers (transferrin levels); LUSC cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.13 0.55 2.73e-28 Colorectal cancer; LUSC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg14092988 chr3:52407081 DNAH1 0.32 6.33 0.33 7.85e-10 Bipolar disorder; LUSC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg08132940 chr7:1081526 C7orf50 -0.51 -6.05 -0.31 3.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7944735 0.508 rs1872167 chr11:47901269 C/T cg20307385 chr11:47447363 PSMC3 -0.55 -5.66 -0.3 3.28e-8 Intraocular pressure; LUSC cis rs7084921 0.608 rs11596883 chr10:101861622 T/C cg02250046 chr10:101825185 CPN1 -0.35 -6.3 -0.33 9.21e-10 Bone mineral density; LUSC cis rs807669 0.868 rs2800973 chr22:19168616 A/G cg02655711 chr22:19163373 SLC25A1 0.88 17.08 0.68 1.88e-47 Metabolite levels; LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg27170947 chr2:26402098 FAM59B 0.72 10.79 0.51 1.8e-23 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24908708 chr8:95835570 INTS8 -0.56 -7.48 -0.38 6.54e-13 Bipolar disorder and schizophrenia; LUSC cis rs977987 0.806 rs8051407 chr16:75448659 A/G cg04384234 chr16:75411784 CFDP1 -0.41 -6.62 -0.34 1.4e-10 Dupuytren's disease; LUSC cis rs9322817 0.691 rs7753202 chr6:105215289 T/C cg02098413 chr6:105308735 HACE1 -0.28 -5.76 -0.3 1.86e-8 Thyroid stimulating hormone; LUSC cis rs36093844 0.752 rs7121363 chr11:85575110 C/T cg25872744 chr11:85566296 CCDC83 -0.47 -6.11 -0.32 2.73e-9 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs3741151 0.773 rs73548693 chr11:73286637 G/A cg17517138 chr11:73019481 ARHGEF17 0.94 8.09 0.4 1.15e-14 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.94 -0.36 2.03e-11 Monocyte percentage of white cells; LUSC cis rs7605827 0.930 rs4668451 chr2:15675285 C/T cg19274914 chr2:15703543 NA 0.45 8.7 0.43 1.49e-16 Educational attainment (years of education); LUSC trans rs3960554 1.000 rs78663390 chr7:75845837 C/A cg19862616 chr7:65841803 NCRNA00174 0.84 9.04 0.44 1.28e-17 Eotaxin levels; LUSC cis rs17095355 0.818 rs1009532 chr10:111840725 C/T cg00817464 chr10:111662876 XPNPEP1 0.53 6.96 0.36 1.81e-11 Biliary atresia; LUSC cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg18132916 chr6:79620363 NA -0.39 -6.0 -0.31 5.22e-9 Intelligence (multi-trait analysis); LUSC cis rs7851660 0.874 rs2417576 chr9:100628707 C/T cg13688889 chr9:100608707 NA -0.56 -8.94 -0.44 2.73e-17 Strep throat; LUSC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg22532475 chr10:104410764 TRIM8 -0.33 -7.24 -0.37 3.03e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs67478160 0.634 rs2144080 chr14:104258761 A/C cg01849466 chr14:104193079 ZFYVE21 -0.58 -9.51 -0.46 3.89e-19 Schizophrenia; LUSC cis rs17286411 0.800 rs60740701 chr16:71875515 G/A cg03805757 chr16:71968109 PKD1L3 0.39 5.72 0.3 2.41e-8 Blood protein levels; LUSC cis rs7659604 0.521 rs4833234 chr4:122694799 T/C cg19748678 chr4:122722346 EXOSC9 -0.48 -6.97 -0.36 1.72e-11 Type 2 diabetes; LUSC trans rs7829975 0.582 rs448231 chr8:8790059 A/T cg27411982 chr8:10470053 RP1L1 -0.36 -6.03 -0.31 4.27e-9 Mood instability; LUSC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg12516959 chr21:47718080 NA 0.45 7.14 0.36 5.9e-12 Testicular germ cell tumor; LUSC cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg20701182 chr2:24300061 SF3B14 -0.88 -11.33 -0.53 2.16e-25 Lymphocyte counts; LUSC cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg05283184 chr6:79620031 NA -0.54 -11.17 -0.52 7.97e-25 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg25019033 chr10:957182 NA -0.53 -6.03 -0.31 4.37e-9 Eosinophil percentage of granulocytes; LUSC cis rs62034325 0.697 rs710410 chr16:28603342 A/G cg16576597 chr16:28551801 NUPR1 0.33 6.7 0.34 8.61e-11 Body mass index; LUSC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg07217954 chr7:1067459 C7orf50 0.54 5.71 0.3 2.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.08 -0.36 8.62e-12 Major depressive disorder; LUSC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg15557168 chr22:42548783 NA -0.45 -6.88 -0.35 2.98e-11 Schizophrenia; LUSC trans rs10097669 0.655 rs2725070 chr8:4439607 G/T cg16451306 chr5:71475356 MAP1B 0.29 6.0 0.31 5.15e-9 Trans fatty acid levels; LUSC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg13560548 chr3:10150139 C3orf24 0.48 6.66 0.34 1.14e-10 Alzheimer's disease; LUSC cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg08975724 chr8:8085496 FLJ10661 0.51 7.94 0.4 3.05e-14 Mood instability; LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg05025164 chr4:1340916 KIAA1530 -0.43 -6.55 -0.34 2.14e-10 Obesity-related traits; LUSC cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg16482183 chr6:26056742 HIST1H1C 0.56 8.34 0.42 2.02e-15 Height; LUSC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg12560992 chr17:57184187 TRIM37 0.85 15.26 0.64 3e-40 Intelligence (multi-trait analysis); LUSC cis rs7582180 0.701 rs11693044 chr2:100922313 T/C cg08017756 chr2:100939284 LONRF2 -0.46 -8.61 -0.43 3.03e-16 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.26 -0.32 1.2e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg11301795 chr4:187892539 NA -0.81 -16.0 -0.66 3.69e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs7113850 0.541 rs74702708 chr11:24226866 T/C ch.11.24196551F chr11:24239977 NA 1.01 8.89 0.44 3.79e-17 Bone fracture in osteoporosis; LUSC cis rs870825 0.616 rs36022027 chr4:185639192 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg02018176 chr4:1364513 KIAA1530 -0.51 -8.79 -0.43 7.81e-17 Obesity-related traits; LUSC cis rs12579753 0.956 rs34146892 chr12:82188581 T/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.16 -0.32 2.07e-9 Resting heart rate; LUSC cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg06618935 chr21:46677482 NA -0.4 -8.04 -0.4 1.59e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12210905 0.688 rs12209174 chr6:27443952 G/A cg08851530 chr6:28072375 NA 0.95 5.82 0.3 1.39e-8 Hip circumference adjusted for BMI; LUSC cis rs3126085 0.877 rs4845742 chr1:152183949 G/A cg26876637 chr1:152193138 HRNR 0.42 5.96 0.31 6.41e-9 Atopic dermatitis; LUSC cis rs7923452 0.938 rs67812762 chr10:30759479 G/T cg18806716 chr10:30721971 MAP3K8 0.58 6.94 0.35 2.06e-11 Itch intensity from mosquito bite; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12926404 chr11:72145533 CLPB -0.48 -6.2 -0.32 1.71e-9 Bipolar disorder and schizophrenia; LUSC cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg13256891 chr4:100009986 ADH5 -0.43 -5.99 -0.31 5.3300000000000004e-09 Alcohol dependence; LUSC trans rs877282 0.945 rs71491311 chr10:791747 G/A cg22713356 chr15:30763199 NA 1.1 15.77 0.65 2.93e-42 Uric acid levels; LUSC cis rs7223966 0.921 rs67018565 chr17:61928055 C/A cg00945038 chr17:61921165 SMARCD2 0.38 5.68 0.3 2.87e-8 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs35146811 0.695 rs858508 chr7:99821381 C/G cg22906224 chr7:99728672 NA -0.5 -6.94 -0.35 2.09e-11 Coronary artery disease; LUSC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg08564027 chr20:61660810 NA 0.9 17.09 0.68 1.7e-47 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg16325326 chr1:53192061 ZYG11B 0.81 13.96 0.61 3.24e-35 Monocyte count; LUSC cis rs782590 0.967 rs4672054 chr2:55773093 C/A cg03859395 chr2:55845619 SMEK2 0.87 16.29 0.67 2.56e-44 Metabolic syndrome; LUSC trans rs12478296 0.748 rs10185596 chr2:243001029 C/A cg01596870 chr19:55963115 NA -0.6 -7.55 -0.38 4.09e-13 Obesity-related traits; LUSC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg03806693 chr22:41940476 POLR3H 0.99 13.78 0.6 1.64e-34 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6964587 1.000 rs28927678 chr7:91715662 C/T cg22709100 chr7:91322751 NA 0.43 6.26 0.32 1.17e-9 Breast cancer; LUSC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg21775007 chr8:11205619 TDH -0.48 -6.94 -0.36 2.07e-11 Neuroticism; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs6005807 0.582 rs8136767 chr22:29008626 G/A cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.13 0.48 3.24e-21 Bipolar disorder; LUSC cis rs7917772 0.507 rs2778036 chr10:104485725 G/A cg05855489 chr10:104503620 C10orf26 -0.69 -8.93 -0.44 2.93e-17 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2882667 0.627 rs1549203 chr5:138468344 A/G cg04439458 chr5:138467593 SIL1 0.44 9.14 0.45 6.21e-18 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7246657 0.653 rs28701616 chr19:37681098 G/A cg23950597 chr19:37808831 NA -0.58 -5.88 -0.31 1.01e-8 Coronary artery calcification; LUSC cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg13319975 chr6:146136371 FBXO30 -0.47 -6.93 -0.35 2.22e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg17366294 chr4:99064904 C4orf37 0.59 10.45 0.5 2.62e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs983392 0.805 rs7926729 chr11:59961786 C/T cg24026212 chr11:59952134 MS4A6A -0.37 -6.37 -0.33 6.17e-10 Alzheimer's disease (late onset); LUSC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs208520 0.690 rs12197578 chr6:66725905 C/T cg07460842 chr6:66804631 NA 1.1 17.21 0.69 5.83e-48 Exhaled nitric oxide output; LUSC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg19592336 chr6:28129416 ZNF389 0.5 6.82 0.35 4.3e-11 Parkinson's disease; LUSC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg22823121 chr1:150693482 HORMAD1 0.52 7.57 0.38 3.79e-13 Melanoma; LUSC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg06453172 chr10:134556979 INPP5A -0.49 -6.09 -0.32 3.1e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg20243544 chr17:37824526 PNMT 0.47 5.85 0.3 1.18e-8 Glomerular filtration rate (creatinine); LUSC cis rs11122272 0.732 rs999010 chr1:231495316 A/G cg06096015 chr1:231504339 EGLN1 0.54 9.5 0.46 4.17e-19 Hemoglobin concentration; LUSC cis rs2625529 0.652 rs2957361 chr15:72345218 G/A cg16672083 chr15:72433130 SENP8 0.49 8.14 0.41 8.06e-15 Red blood cell count; LUSC cis rs939658 0.567 rs11631829 chr15:79446529 C/T cg17916960 chr15:79447300 NA -0.48 -9.88 -0.48 2.38e-20 Refractive error; LUSC cis rs870825 0.616 rs56844261 chr4:185632478 T/C cg04058563 chr4:185651563 MLF1IP 0.87 13.33 0.59 8.18e-33 Blood protein levels; LUSC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg18252515 chr7:66147081 NA -1.22 -13.52 -0.59 1.63e-33 Diabetic kidney disease; LUSC cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg01689657 chr7:91764605 CYP51A1 0.33 5.99 0.31 5.53e-9 Breast cancer; LUSC cis rs4704187 0.687 rs6862740 chr5:74405749 A/T cg03227963 chr5:74354835 NA 0.32 6.87 0.35 3.09e-11 Response to amphetamines; LUSC cis rs4917300 0.626 rs28375965 chr8:143103882 A/G cg25363559 chr8:143086065 NA -0.32 -7.25 -0.37 2.98e-12 Amyotrophic lateral sclerosis; LUSC cis rs6669072 0.679 rs3845562 chr1:91313811 A/C cg08895590 chr1:91227319 NA 0.33 7.01 0.36 1.36e-11 Cognitive function; LUSC cis rs2625529 0.761 rs8028532 chr15:72348054 G/A cg16672083 chr15:72433130 SENP8 -0.51 -7.48 -0.38 6.51e-13 Red blood cell count; LUSC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg06627628 chr2:24431161 ITSN2 -0.61 -7.32 -0.37 1.88e-12 Lymphocyte counts; LUSC cis rs7385804 0.761 rs576236 chr7:100316975 C/T cg16850897 chr7:100343110 ZAN 0.38 6.26 0.32 1.17e-9 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; LUSC cis rs6964587 0.900 rs7783674 chr7:91784212 T/A cg17063962 chr7:91808500 NA 0.6 9.52 0.46 3.55e-19 Breast cancer; LUSC cis rs13108904 0.743 rs11729037 chr4:1387298 A/G cg16405210 chr4:1374714 KIAA1530 -0.57 -8.92 -0.44 3.07e-17 Obesity-related traits; LUSC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg10645314 chr2:3704589 ALLC -0.49 -7.33 -0.37 1.72e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg17376030 chr22:41985996 PMM1 -0.47 -5.99 -0.31 5.3e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4740619 0.619 rs4741557 chr9:16031080 C/T cg14451791 chr9:16040625 NA 0.33 6.47 0.33 3.49e-10 Body mass index; LUSC cis rs8016982 0.632 rs7142641 chr14:81677454 A/G cg01989461 chr14:81687754 GTF2A1 0.52 6.96 0.36 1.84e-11 Schizophrenia; LUSC cis rs7267979 0.932 rs6115214 chr20:25557426 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.84 -17.95 -0.7 6.22e-51 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7605827 0.893 rs35123590 chr2:15708639 T/C cg19274914 chr2:15703543 NA 0.44 8.34 0.41 2.04e-15 Educational attainment (years of education); LUSC cis rs612683 0.735 rs10493923 chr1:100930254 A/G cg06223162 chr1:101003688 GPR88 -0.49 -9.27 -0.45 2.4e-18 Breast cancer; LUSC cis rs12891047 0.804 rs72723196 chr14:68283697 G/C cg20999565 chr14:68265668 ZFYVE26 0.38 5.79 0.3 1.58e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg06873352 chr17:61820015 STRADA 0.71 12.8 0.57 8.38e-31 Prudent dietary pattern; LUSC cis rs7474896 0.526 rs1208716 chr10:38089273 T/A cg25427524 chr10:38739819 LOC399744 -0.44 -5.66 -0.3 3.31e-8 Obesity (extreme); LUSC cis rs1018697 0.966 rs10748831 chr10:104558743 T/C cg04362960 chr10:104952993 NT5C2 0.46 6.35 0.33 7.22e-10 Colorectal adenoma (advanced); LUSC cis rs1670533 1.000 rs10003009 chr4:1050849 G/A cg02018176 chr4:1364513 KIAA1530 0.46 6.45 0.33 3.82e-10 Recombination rate (females); LUSC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs17102423 0.623 rs4902368 chr14:65612048 A/G cg11161011 chr14:65562177 MAX 0.62 8.6 0.43 3.05e-16 Obesity-related traits; LUSC cis rs478222 1.000 rs551573 chr2:25305504 A/G cg01884057 chr2:25150051 NA 0.28 6.12 0.32 2.61e-9 Type 1 diabetes; LUSC cis rs9865818 0.702 rs9834159 chr3:188115232 T/A cg23651889 chr3:188115336 LPP -0.38 -5.88 -0.31 1.01e-8 Allergic sensitization; LUSC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg08470875 chr2:26401718 FAM59B -0.65 -8.6 -0.43 3.12e-16 Gut microbiome composition (summer); LUSC cis rs9517320 1.000 rs912337 chr13:99141272 A/G cg07423050 chr13:99094983 FARP1 -0.36 -6.98 -0.36 1.6e-11 Longevity; LUSC cis rs73206853 0.841 rs11065631 chr12:110778383 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 6.44 0.33 4.25e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs3540 0.533 rs937793 chr15:91053583 A/G cg10434728 chr15:90938212 IQGAP1 -0.38 -7.06 -0.36 9.45e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg07918776 chr15:49170303 SHC4;EID1 -0.43 -6.65 -0.34 1.17e-10 Electrocardiographic conduction measures; LUSC cis rs950169 0.887 rs35986397 chr15:84955107 G/A cg17507749 chr15:85114479 UBE2QP1 0.66 8.19 0.41 5.47e-15 Schizophrenia; LUSC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg20135002 chr11:47629003 NA 0.51 7.99 0.4 2.26e-14 Subjective well-being; LUSC cis rs7824557 0.628 rs11994376 chr8:11202960 G/A cg27411982 chr8:10470053 RP1L1 0.37 5.66 0.3 3.28e-8 Retinal vascular caliber; LUSC cis rs1143633 0.553 rs2723197 chr2:113689747 G/A cg06156847 chr2:113672199 IL1F7 0.29 6.14 0.32 2.3e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg15147215 chr3:52552868 STAB1 -0.31 -6.13 -0.32 2.47e-9 Bipolar disorder; LUSC cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg11890956 chr21:40555474 PSMG1 1.04 21.65 0.76 1.47e-65 Cognitive function; LUSC cis rs4690686 0.538 rs4690687 chr4:177259635 A/G cg17059388 chr4:177262070 NA -0.42 -7.85 -0.39 5.54e-14 Essential tremor; LUSC cis rs11971779 0.680 rs7808740 chr7:139028955 G/T cg07862535 chr7:139043722 LUC7L2 0.53 6.6 0.34 1.64e-10 Diisocyanate-induced asthma; LUSC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg03806693 chr22:41940476 POLR3H 0.99 13.85 0.6 9.09e-35 Vitiligo; LUSC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg25258033 chr6:167368657 RNASET2 0.45 7.08 0.36 8.83e-12 Crohn's disease; LUSC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg03609598 chr5:56110824 MAP3K1 -0.42 -6.25 -0.32 1.26e-9 Initial pursuit acceleration; LUSC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg15962314 chr1:44399869 ARTN 0.29 6.76 0.35 6.16e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; LUSC trans rs953492 0.644 rs10926974 chr1:243396326 C/T cg25284624 chr1:224180302 NA -0.44 -6.66 -0.34 1.12e-10 Diastolic blood pressure; LUSC cis rs9814567 0.865 rs9834981 chr3:134282279 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.85 -14.02 -0.61 1.89e-35 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10876993 0.928 rs2169988 chr12:58071165 G/A cg15848620 chr12:58087721 OS9 -0.57 -8.24 -0.41 4.01e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs9457247 1.000 rs393558 chr6:167397750 A/C cg07741184 chr6:167504864 NA 0.36 6.53 0.34 2.52e-10 Crohn's disease; LUSC cis rs59698941 0.843 rs61541414 chr5:132226106 G/A cg14825688 chr5:132208181 LEAP2 -0.51 -6.1 -0.32 2.89e-9 Apolipoprotein A-IV levels; LUSC cis rs1007190 0.881 rs16939676 chr17:42976347 C/A cg15406952 chr17:42872593 NA 0.56 5.76 0.3 1.88e-8 DNA methylation (variation); LUSC cis rs138491296 1 rs138491296 chr17:27961561 GATTATT/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.64 -9.9 -0.48 2.03e-20 White blood cell count; LUSC cis rs12928939 0.862 rs7197104 chr16:71794061 C/T cg03805757 chr16:71968109 PKD1L3 -0.43 -6.29 -0.33 1.01e-9 Post bronchodilator FEV1; LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.4 0.53 1.24e-25 Prudent dietary pattern; LUSC cis rs514406 0.798 rs504816 chr1:53307957 T/G cg25767906 chr1:53392781 SCP2 -0.53 -10.33 -0.49 7.07e-22 Monocyte count; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg02550027 chr10:102046474 BLOC1S2 0.72 5.98 0.31 5.72e-9 Cognitive performance; LUSC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg23630131 chr7:65973040 NA 0.21 5.94 0.31 7.16e-9 Aortic root size; LUSC cis rs7605827 0.893 rs7590540 chr2:15719652 A/T cg19274914 chr2:15703543 NA 0.46 8.75 0.43 1.08e-16 Educational attainment (years of education); LUSC cis rs79220007 1.000 rs79220007 chr6:26098474 T/C cg17691542 chr6:26056736 HIST1H1C 0.89 5.68 0.3 2.86e-8 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs6961069 0.621 rs2065666 chr7:80230807 G/C cg04458919 chr7:80252533 CD36 -0.41 -7.17 -0.37 4.95e-12 Platelet count; LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.48 0.53 6.2e-26 Prudent dietary pattern; LUSC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg06481639 chr22:41940642 POLR3H -0.55 -6.12 -0.32 2.63e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs4285028 0.696 rs3915060 chr3:121712980 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.56 7.19 0.37 4.19e-12 Multiple sclerosis; LUSC cis rs4727027 0.631 rs62507511 chr7:148796080 C/A cg23158103 chr7:148848205 ZNF398 -0.43 -6.77 -0.35 5.95e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg15839431 chr19:19639596 YJEFN3 -0.41 -5.68 -0.3 2.93e-8 Tonsillectomy; LUSC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg17264618 chr3:40429014 ENTPD3 -0.34 -7.35 -0.37 1.57e-12 Renal cell carcinoma; LUSC cis rs2290416 0.579 rs58573550 chr8:144681714 G/A cg14809332 chr8:144654887 C8orf73 0.54 6.51 0.34 2.83e-10 Attention deficit hyperactivity disorder; LUSC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg05535760 chr7:792225 HEATR2 0.94 9.95 0.48 1.32e-20 Cerebrospinal P-tau181p levels; LUSC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg07936489 chr17:37558343 FBXL20 -0.72 -9.75 -0.47 6.34e-20 Glomerular filtration rate (creatinine); LUSC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg20607287 chr7:12443886 VWDE -0.6 -6.2 -0.32 1.65e-9 Coronary artery disease; LUSC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.16 -0.36 5.11e-12 Menopause (age at onset); LUSC cis rs12900413 0.687 rs28493563 chr15:90309505 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.71 -0.3 2.47e-8 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.42 -6.65 -0.34 1.22e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg16325326 chr1:53192061 ZYG11B 0.82 14.11 0.61 8.6e-36 Monocyte count; LUSC cis rs4566357 1.000 rs3769637 chr2:227922623 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.91 -0.31 8.3e-9 Coronary artery disease; LUSC cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg01483505 chr11:975446 AP2A2 0.4 5.81 0.3 1.44e-8 Alzheimer's disease (late onset); LUSC cis rs9660180 0.967 rs6687065 chr1:1778469 A/G cg17747265 chr1:1875780 NA -0.75 -17.58 -0.69 1.89e-49 Body mass index; LUSC cis rs11997175 1.000 rs7838577 chr8:33760802 A/G ch.8.33884649F chr8:33765107 NA 0.52 8.23 0.41 4.15e-15 Body mass index; LUSC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7786877 0.583 rs41303510 chr7:100226129 C/T cg16850897 chr7:100343110 ZAN -0.47 -5.82 -0.3 1.37e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg00784671 chr22:46762841 CELSR1 -0.49 -6.06 -0.31 3.75e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC trans rs804280 1.000 rs804280 chr8:11612698 G/T cg06636001 chr8:8085503 FLJ10661 0.56 8.51 0.42 6.03e-16 Myopia (pathological); LUSC cis rs10781543 0.776 rs4378078 chr9:139375962 A/G cg14169450 chr9:139327907 INPP5E 0.46 8.26 0.41 3.53e-15 Monocyte percentage of white cells; LUSC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.28 -0.45 2.27e-18 Gut microbiome composition (summer); LUSC cis rs11997175 0.740 rs4733462 chr8:33679904 A/G ch.8.33884649F chr8:33765107 NA 0.39 6.04 0.31 4.04e-9 Body mass index; LUSC cis rs9300255 0.537 rs1727334 chr12:123714236 A/G cg05973401 chr12:123451056 ABCB9 0.53 6.59 0.34 1.73e-10 Neutrophil percentage of white cells; LUSC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg25204440 chr1:209979598 IRF6 0.51 5.85 0.3 1.19e-8 Cleft lip with or without cleft palate; LUSC cis rs6547741 1.000 rs6718128 chr2:27833752 A/G cg12559939 chr2:27858050 GPN1 -0.41 -6.4 -0.33 5.37e-10 Oral cavity cancer; LUSC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.54 -8.08 -0.4 1.23e-14 Axial length; LUSC cis rs11098499 0.644 rs6855918 chr4:120546299 C/T cg24375607 chr4:120327624 NA 0.72 11.39 0.53 1.28e-25 Corneal astigmatism; LUSC cis rs6580649 0.941 rs7296913 chr12:48488920 G/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.03 -0.31 4.29e-9 Lung cancer; LUSC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg19748678 chr4:122722346 EXOSC9 0.74 10.58 0.5 9.68e-23 Type 2 diabetes; LUSC cis rs2248020 0.501 rs2263368 chr11:93264680 A/C cg15737290 chr11:93063684 CCDC67 0.48 6.87 0.35 3.16e-11 Insulin levels in response to oral glucose tolerance test (30 minutes); LUSC cis rs7241530 0.662 rs6506752 chr18:75904844 C/A cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC cis rs7824557 0.545 rs2736303 chr8:11236850 C/T cg27411982 chr8:10470053 RP1L1 -0.37 -5.79 -0.3 1.63e-8 Retinal vascular caliber; LUSC cis rs10540 1.000 rs61876339 chr11:495283 T/C cg08088566 chr11:430123 ANO9 0.64 7.14 0.36 5.87e-12 Body mass index; LUSC trans rs11949289 1.000 rs58116711 chr5:28344497 C/T cg18220921 chr1:242687527 PLD5 0.35 5.96 0.31 6.57e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 20.89 0.75 1.43e-62 Prudent dietary pattern; LUSC cis rs854765 0.583 rs4925125 chr17:17794444 T/C cg16928487 chr17:17741425 SREBF1 0.43 8.3 0.41 2.61e-15 Total body bone mineral density; LUSC cis rs1865721 1.000 rs7244787 chr18:73195162 T/C cg26385618 chr18:73139727 C18orf62 -0.48 -8.0 -0.4 2.12e-14 Intelligence; LUSC cis rs9325144 0.554 rs1906264 chr12:38739490 A/G cg13010199 chr12:38710504 ALG10B 0.48 7.4 0.38 1.13e-12 Morning vs. evening chronotype; LUSC cis rs6733011 0.531 rs13004923 chr2:99497561 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.49 -6.87 -0.35 3.1e-11 Bipolar disorder; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05684569 chr16:81929465 PLCG2 -0.79 -6.56 -0.34 2.01e-10 Cognitive performance; LUSC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg00310523 chr12:86230176 RASSF9 0.42 7.57 0.38 3.61e-13 Major depressive disorder; LUSC cis rs6692729 0.966 rs6426547 chr1:227004367 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 6.72 0.35 7.77e-11 Electrodermal activity; LUSC cis rs7264396 0.733 rs2425105 chr20:34312834 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.44 -0.46 6.78e-19 Total cholesterol levels; LUSC cis rs28386778 0.765 rs1974435 chr17:61994096 G/A cg07362569 chr17:61921086 SMARCD2 -0.29 -5.84 -0.3 1.22e-8 Prudent dietary pattern; LUSC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs2439831 0.702 rs9989313 chr15:44152817 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.76 6.81 0.35 4.6e-11 Lung cancer in ever smokers; LUSC cis rs7408868 1.000 rs757472 chr19:15273221 T/C cg14696996 chr19:15285081 NOTCH3 1.01 9.45 0.46 6.13e-19 Pulse pressure; LUSC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11890956 chr21:40555474 PSMG1 1.04 21.28 0.76 3.93e-64 Cognitive function; LUSC cis rs6121246 0.567 rs6060260 chr20:30192907 C/T cg13852791 chr20:30311386 BCL2L1 0.74 8.37 0.42 1.65e-15 Mean corpuscular hemoglobin; LUSC cis rs9300255 0.596 rs4460848 chr12:123677810 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.71 -0.34 8.3e-11 Neutrophil percentage of white cells; LUSC cis rs1670533 1.000 rs6837145 chr4:1071067 T/C cg02018176 chr4:1364513 KIAA1530 0.46 6.51 0.34 2.81e-10 Recombination rate (females); LUSC cis rs12681287 0.640 rs61106663 chr8:87477081 G/C cg27223183 chr8:87520930 FAM82B -0.53 -7.16 -0.36 5.04e-12 Caudate activity during reward; LUSC cis rs826838 0.616 rs9668847 chr12:38614669 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.84 0.44 5.5e-17 Heart rate; LUSC cis rs708547 0.581 rs781661 chr4:57780307 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.47 -6.79 -0.35 5.02e-11 Response to bleomycin (chromatid breaks); LUSC cis rs13089785 1.000 rs13092912 chr3:123604942 C/T cg02012769 chr3:123398346 MYLK 0.32 5.85 0.3 1.16e-8 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg10729496 chr3:10149963 C3orf24 0.55 7.29 0.37 2.23e-12 Alzheimer's disease; LUSC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -22.64 -0.78 1.96e-69 Coronary artery disease; LUSC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg18758796 chr5:131593413 PDLIM4 0.44 7.59 0.38 3.3e-13 Breast cancer; LUSC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg06008330 chr7:65541103 ASL -0.4 -6.16 -0.32 2.14e-9 Aortic root size; LUSC cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg22782873 chr19:19639568 YJEFN3 0.49 6.15 0.32 2.19e-9 Bipolar disorder; LUSC cis rs7107174 1.000 rs10899470 chr11:78020052 C/T cg02023728 chr11:77925099 USP35 0.48 6.76 0.35 6.33e-11 Testicular germ cell tumor; LUSC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg18225595 chr11:63971243 STIP1 0.63 10.62 0.5 6.96e-23 Platelet count; LUSC cis rs4930103 0.935 rs11042170 chr11:2021625 C/T cg06197492 chr11:2016605 H19 0.41 6.74 0.35 7.07e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs7605827 0.930 rs4668910 chr2:15608013 C/A cg19274914 chr2:15703543 NA 0.46 8.85 0.44 5.37e-17 Educational attainment (years of education); LUSC cis rs10986311 0.722 rs6478660 chr9:127133920 A/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.44 7.22 0.37 3.59e-12 Vitiligo; LUSC cis rs7180079 0.620 rs498806 chr15:64850939 C/T cg08069370 chr15:64387884 SNX1 0.51 5.74 0.3 2.13e-8 Monocyte count; LUSC cis rs3857536 0.741 rs4710582 chr6:66939984 T/G cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg15147215 chr3:52552868 STAB1 -0.36 -7.33 -0.37 1.74e-12 Electroencephalogram traits; LUSC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg03563238 chr19:33554763 RHPN2 -0.34 -5.73 -0.3 2.19e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg13010199 chr12:38710504 ALG10B 0.7 12.06 0.55 4.68e-28 Heart rate; LUSC cis rs734999 0.588 rs3748817 chr1:2525665 T/C cg18932078 chr1:2524107 MMEL1 0.29 6.41 0.33 4.97e-10 Ulcerative colitis; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg04025307 chr7:1156635 C7orf50 0.41 6.28 0.32 1.06e-9 Longevity;Endometriosis; LUSC cis rs2580764 0.515 rs4672005 chr2:55246551 C/T cg20993754 chr2:55226987 RTN4 0.34 5.71 0.3 2.45e-8 Mean platelet volume; LUSC cis rs7188861 0.681 rs72773819 chr16:11406792 C/A cg00044050 chr16:11439710 C16orf75 0.57 5.78 0.3 1.74e-8 HDL cholesterol; LUSC trans rs2204008 0.837 rs7315255 chr12:37949279 G/A cg06521331 chr12:34319734 NA -0.39 -5.96 -0.31 6.34e-9 Bladder cancer; LUSC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg20406979 chr6:167373233 NA 0.25 5.96 0.31 6.39e-9 Crohn's disease; LUSC cis rs10435719 0.902 rs7459983 chr8:11807221 T/C cg21775007 chr8:11205619 TDH 0.46 6.48 0.33 3.28e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.34e-11 Menopause (age at onset); LUSC cis rs2439831 0.850 rs12442297 chr15:44168470 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.85 8.11 0.41 9.67e-15 Lung cancer in ever smokers; LUSC cis rs9361491 0.657 rs9343801 chr6:79462275 G/A cg05283184 chr6:79620031 NA -0.32 -5.9 -0.31 9.16e-9 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg11663144 chr21:46675770 NA -0.41 -7.27 -0.37 2.62e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg08754478 chr10:133766260 PPP2R2D -0.62 -7.84 -0.39 6.1e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC trans rs2243480 1.000 rs160652 chr7:65538431 A/G cg10756647 chr7:56101905 PSPH 0.88 8.95 0.44 2.54e-17 Diabetic kidney disease; LUSC cis rs12940923 1.000 rs12451466 chr17:56378067 G/A cg19466818 chr17:56409534 MIR142 -0.38 -6.51 -0.34 2.71e-10 Circulating myeloperoxidase levels (plasma); LUSC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.0 -0.68 3.84e-47 Gut microbiome composition (summer); LUSC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg11764359 chr7:65958608 NA 0.63 9.48 0.46 4.74e-19 Aortic root size; LUSC cis rs9768139 0.708 rs896779 chr7:158113390 T/G cg24154853 chr7:158122151 PTPRN2 0.45 8.86 0.44 4.77e-17 Calcium levels; LUSC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg14298792 chr15:30685198 CHRFAM7A -0.63 -8.32 -0.41 2.28e-15 Huntington's disease progression; LUSC cis rs9325144 0.560 rs10876005 chr12:39126149 C/G cg26384229 chr12:38710491 ALG10B -0.64 -10.54 -0.5 1.34e-22 Morning vs. evening chronotype; LUSC cis rs11971779 0.680 rs7795520 chr7:139079207 A/G cg23387468 chr7:139079360 LUC7L2 0.42 6.31 0.33 8.87e-10 Diisocyanate-induced asthma; LUSC cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.85 0.3 1.16e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg13628971 chr7:2884303 GNA12 0.43 6.37 0.33 6.31e-10 Height; LUSC cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg05283184 chr6:79620031 NA -0.57 -11.77 -0.54 5.31e-27 Intelligence (multi-trait analysis); LUSC cis rs2625529 0.824 rs12903484 chr15:72299481 G/A cg16672083 chr15:72433130 SENP8 -0.52 -7.58 -0.38 3.51e-13 Red blood cell count; LUSC cis rs8114671 0.967 rs6088734 chr20:33745046 A/T cg24642439 chr20:33292090 TP53INP2 0.39 5.66 0.3 3.3e-8 Height; LUSC cis rs1965732 1.000 rs6707320 chr2:3708966 A/G cg25251562 chr2:3704773 ALLC -0.4 -7.06 -0.36 9.54e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7246967 0.611 rs2194113 chr19:22958075 C/T cg23217946 chr19:22817039 ZNF492 0.43 5.86 0.31 1.12e-8 Bronchopulmonary dysplasia; LUSC cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg26395211 chr5:140044315 WDR55 -0.45 -6.99 -0.36 1.51e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs9796 0.621 rs28737302 chr15:41469943 G/A cg18705301 chr15:41695430 NDUFAF1 -0.48 -8.53 -0.42 5.24e-16 Menopause (age at onset); LUSC cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.57 0.57 6.1e-30 Motion sickness; LUSC cis rs9479482 1.000 rs11155696 chr6:150357283 G/A cg25797454 chr6:150327115 RAET1K 0.35 7.98 0.4 2.34e-14 Alopecia areata; LUSC cis rs10979 1.000 rs9484767 chr6:143887912 C/A cg25407410 chr6:143891975 LOC285740 -0.75 -12.09 -0.55 3.8e-28 Hypospadias; LUSC cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg15423357 chr2:25149977 NA 0.46 9.17 0.45 5.08e-18 Body mass index; LUSC trans rs6869502 0.871 rs13354207 chr5:110151791 C/G cg14733989 chr19:17622331 PGLS -0.47 -6.25 -0.32 1.25e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6499188 0.522 rs8046299 chr16:68672346 G/A cg02972257 chr16:68554789 NA -0.48 -6.21 -0.32 1.61e-9 Ulcerative colitis; LUSC cis rs2040771 0.872 rs12485084 chr22:19162326 A/G cg02655711 chr22:19163373 SLC25A1 0.52 9.33 0.45 1.51e-18 Metabolite levels (small molecules and protein measures); LUSC cis rs10193935 1.000 rs62144748 chr2:42419468 C/T cg27598129 chr2:42591480 NA -0.62 -8.45 -0.42 9.38e-16 Colonoscopy-negative controls vs population controls; LUSC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg10523679 chr1:76189770 ACADM 0.81 10.26 0.49 1.16e-21 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs8141529 0.509 rs5762863 chr22:29253335 A/C cg15103426 chr22:29168792 CCDC117 0.49 6.25 0.32 1.24e-9 Lymphocyte counts; LUSC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg16339924 chr4:17578868 LAP3 -0.52 -7.96 -0.4 2.63e-14 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.9 -12.84 -0.57 5.88e-31 Platelet count; LUSC cis rs4631830 0.900 rs4630241 chr10:51532751 G/A cg20129853 chr10:51489980 NA -0.35 -7.0 -0.36 1.38e-11 Prostate-specific antigen levels; LUSC cis rs524023 0.957 rs12365089 chr11:64364735 A/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.2 -0.49 1.95e-21 Urate levels in obese individuals; LUSC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg17541715 chr7:1216824 NA -0.35 -5.71 -0.3 2.51e-8 Longevity;Endometriosis; LUSC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.63 0.34 1.34e-10 Lung cancer; LUSC cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg04111992 chr7:158790115 NA -0.43 -6.75 -0.35 6.5e-11 Facial morphology (factor 20); LUSC cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg19628046 chr18:33552617 C18orf21 0.52 6.32 0.33 8.4e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs9399135 0.935 rs2150680 chr6:135347131 G/C cg22676075 chr6:135203613 NA 0.47 7.4 0.38 1.12e-12 Red blood cell count; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg14877820 chr3:16306698 OXNAD1;DPH3 0.68 6.25 0.32 1.26e-9 Body mass index; LUSC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.05 0.36 1.03e-11 Parkinson's disease; LUSC cis rs2742417 0.565 rs2673031 chr3:45756986 A/G cg10512202 chr3:45649293 LIMD1 0.36 6.06 0.31 3.65e-9 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.52 -0.46 3.68e-19 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs8073060 0.586 rs225250 chr17:33941963 A/G cg19694781 chr19:47549865 TMEM160 -1.14 -18.49 -0.71 4.69e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs4253772 0.591 rs9615935 chr22:46686115 T/G cg00784671 chr22:46762841 CELSR1 -0.55 -7.0 -0.36 1.41e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg13877915 chr19:58951672 ZNF132 0.5 7.96 0.4 2.68e-14 Uric acid clearance; LUSC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg18538332 chr22:24372958 LOC391322 -0.42 -7.54 -0.38 4.62e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs4073416 0.568 rs12885842 chr14:65918652 C/T cg03016385 chr14:66212404 NA -0.42 -6.67 -0.34 1.07e-10 N-glycan levels; LUSC cis rs951366 0.576 rs7513645 chr1:205698026 A/G cg07157834 chr1:205819609 PM20D1 0.45 5.93 0.31 7.77e-9 Menarche (age at onset); LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg11645453 chr3:52864694 ITIH4 0.31 7.3 0.37 2.08e-12 Electroencephalogram traits; LUSC cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg22601191 chr20:60968625 CABLES2 -0.36 -5.77 -0.3 1.81e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC cis rs9393692 0.905 rs9357004 chr6:26303319 A/G cg13736514 chr6:26305472 NA -0.47 -9.45 -0.46 6.09e-19 Educational attainment; LUSC cis rs7954584 0.616 rs10743185 chr12:122356435 G/A cg13699009 chr12:122356056 WDR66 0.45 6.81 0.35 4.68e-11 Mean corpuscular volume; LUSC cis rs4803468 1.000 rs4803468 chr19:41922352 A/G cg09537434 chr19:41945824 ATP5SL -0.91 -15.86 -0.66 1.23e-42 Height; LUSC cis rs1178968 1.000 rs13240408 chr7:72758023 T/C cg25889504 chr7:72793014 NA 0.58 7.54 0.38 4.5e-13 Triglyceride levels; LUSC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg07936489 chr17:37558343 FBXL20 -0.69 -10.11 -0.48 3.92e-21 Glomerular filtration rate (creatinine); LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.5 8.16 0.41 6.75e-15 Lymphocyte counts; LUSC cis rs477692 0.673 rs579325 chr10:131363688 C/T cg26102564 chr10:131424627 MGMT 0.43 6.46 0.33 3.73e-10 Response to temozolomide; LUSC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg22875332 chr1:76189707 ACADM 0.86 15.72 0.65 4.61e-42 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs11229555 0.645 rs35279927 chr11:58212129 G/T cg15696309 chr11:58395628 NA -0.64 -7.79 -0.39 8.6e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.54e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs11214589 0.905 rs2186799 chr11:113242533 G/T cg14159747 chr11:113255604 NA 0.29 6.97 0.36 1.72e-11 Neuroticism; LUSC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg12564285 chr5:131593104 PDLIM4 0.44 7.92 0.4 3.48e-14 Breast cancer; LUSC cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg24812749 chr6:127587940 RNF146 0.91 13.51 0.59 1.7e-33 Breast cancer; LUSC cis rs3960554 0.867 rs79359354 chr7:75702597 G/A cg17325771 chr7:75508891 RHBDD2 -0.4 -5.88 -0.31 9.71e-9 Eotaxin levels; LUSC cis rs9296092 0.517 rs3912041 chr6:33521271 T/C cg13560919 chr6:33536144 NA -0.82 -15.74 -0.65 3.89e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs11112613 0.713 rs11112587 chr12:105941285 G/A cg03607813 chr12:105948248 NA 0.78 12.11 0.55 3.16e-28 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs6060717 0.536 rs6060704 chr20:34530270 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -5.8 -0.3 1.53e-8 Hip circumference adjusted for BMI; LUSC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg01585723 chr16:33734837 NA 0.46 7.99 0.4 2.25e-14 Menopause (age at onset); LUSC cis rs708547 0.676 rs11133470 chr4:57864926 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.81 -0.3 1.42e-8 Response to bleomycin (chromatid breaks); LUSC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg25288140 chr17:41278341 BRCA1;NBR2 0.38 5.77 0.3 1.79e-8 Menopause (age at onset); LUSC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg05890377 chr2:74357713 NA 0.73 14.22 0.61 3.3e-36 Gestational age at birth (maternal effect); LUSC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg24675658 chr1:53192096 ZYG11B -0.63 -9.83 -0.47 3.43e-20 Monocyte count; LUSC cis rs7084921 0.608 rs4475856 chr10:101833339 G/T cg11888571 chr10:102027403 CWF19L1 -0.42 -5.81 -0.3 1.47e-8 Bone mineral density; LUSC cis rs9640161 0.789 rs10248490 chr7:150051418 C/G cg17279839 chr7:150038598 RARRES2 0.42 6.54 0.34 2.36e-10 Blood protein levels;Circulating chemerin levels; LUSC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg10360139 chr7:1886902 MAD1L1 -0.4 -6.02 -0.31 4.53e-9 Bipolar disorder and schizophrenia; LUSC cis rs1371867 1.000 rs1371867 chr8:101330209 A/C cg06002616 chr8:101225028 SPAG1 -0.42 -7.02 -0.36 1.26e-11 Atrioventricular conduction; LUSC cis rs7336332 0.600 rs9579083 chr13:28017270 G/C cg22138327 chr13:27999177 GTF3A 0.75 9.71 0.47 8.31e-20 Weight; LUSC cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg23625390 chr15:77176239 SCAPER 0.54 8.49 0.42 6.9e-16 Blood metabolite levels; LUSC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg02018176 chr4:1364513 KIAA1530 -0.5 -8.48 -0.42 7.18e-16 Obesity-related traits; LUSC cis rs2777491 0.574 rs72739644 chr15:41719706 A/G cg18705301 chr15:41695430 NDUFAF1 -1.01 -20.77 -0.75 4.3500000000000004e-62 Ulcerative colitis; LUSC trans rs10802346 0.545 rs4607841 chr1:246373295 T/C cg22732515 chr19:44031385 ETHE1 0.64 10.43 0.5 2.99e-22 Fractional exhaled nitric oxide (childhood); LUSC cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg10523679 chr1:76189770 ACADM -0.51 -7.44 -0.38 8.34e-13 Daytime sleep phenotypes; LUSC trans rs1499614 1.000 rs1267818 chr7:66107024 C/T cg10756647 chr7:56101905 PSPH 0.88 8.96 0.44 2.28e-17 Gout; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.68 10.53 0.5 1.37e-22 Lymphocyte counts; LUSC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs12950390 0.853 rs59513807 chr17:45867925 G/A cg03474202 chr17:45855739 NA -0.31 -7.07 -0.36 9.11e-12 IgG glycosylation; LUSC trans rs1459104 0.866 rs67929427 chr11:54824182 C/T cg03929089 chr4:120376271 NA 0.72 6.26 0.32 1.17e-9 Body mass index; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.68 -10.51 -0.5 1.59e-22 Lymphocyte counts; LUSC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg13298116 chr11:62369859 EML3;MTA2 0.59 9.61 0.47 1.77e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9807989 0.801 rs6734742 chr2:102967857 C/T cg09003973 chr2:102972529 NA 0.44 6.05 0.31 3.93e-9 Asthma; LUSC cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.84 -0.44 5.49e-17 Monocyte percentage of white cells; LUSC cis rs738322 0.804 rs4821742 chr22:38514839 T/C cg17652424 chr22:38574118 PLA2G6 -0.29 -5.85 -0.3 1.16e-8 Cutaneous nevi; LUSC cis rs56283067 0.847 rs10948156 chr6:44689459 G/A cg18551225 chr6:44695536 NA -0.5 -8.39 -0.42 1.36e-15 Total body bone mineral density; LUSC cis rs34779708 0.677 rs112355105 chr10:35550294 A/T cg03585969 chr10:35415529 CREM 0.53 7.3 0.37 2.16e-12 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg04450456 chr4:17643702 FAM184B 0.37 6.17 0.32 1.96e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg25817165 chr18:72167213 CNDP2 -0.73 -8.84 -0.44 5.42e-17 Refractive error; LUSC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg03188948 chr7:1209495 NA 0.67 7.04 0.36 1.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg14092988 chr3:52407081 DNAH1 0.3 5.87 0.31 1.06e-8 Bipolar disorder; LUSC trans rs7829975 0.606 rs7819827 chr8:8797055 G/C cg27411982 chr8:10470053 RP1L1 -0.39 -6.38 -0.33 5.91e-10 Mood instability; LUSC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.03e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg05347473 chr6:146136440 FBXO30 -0.66 -11.72 -0.54 8.35e-27 Lobe attachment (rater-scored or self-reported); LUSC cis rs12220238 1.000 rs10824090 chr10:75923446 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 7.2 0.37 3.89e-12 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg17971929 chr21:40555470 PSMG1 0.79 13.92 0.61 4.74e-35 Cognitive function; LUSC cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg05347473 chr6:146136440 FBXO30 0.44 7.54 0.38 4.49e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs7582180 0.845 rs11683088 chr2:100920667 C/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.51 -0.42 6.11e-16 Intelligence (multi-trait analysis); LUSC cis rs514406 0.763 rs6685599 chr1:53213172 G/A cg24675658 chr1:53192096 ZYG11B 0.6 9.33 0.45 1.51e-18 Monocyte count; LUSC trans rs1994135 0.692 rs1816958 chr12:33695066 A/T cg13010199 chr12:38710504 ALG10B 0.47 6.6 0.34 1.61e-10 Resting heart rate; LUSC cis rs2652822 0.935 rs2292038 chr15:63449680 C/G cg02713581 chr15:63449717 RPS27L -0.42 -6.72 -0.35 7.65e-11 Metabolic traits; LUSC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs10986311 0.832 rs10119911 chr9:127127172 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.39 6.27 0.32 1.1e-9 Vitiligo; LUSC cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.36 -6.61 -0.34 1.51e-10 Monocyte percentage of white cells; LUSC cis rs41271951 0.512 rs115968379 chr1:151050087 A/C cg11822372 chr1:151115635 SEMA6C -0.78 -7.18 -0.37 4.51e-12 Blood protein levels; LUSC cis rs7712401 0.715 rs13163098 chr5:122346536 A/G cg19077854 chr5:122220652 SNX24 -0.41 -8.85 -0.44 5.29e-17 Mean platelet volume; LUSC cis rs6088580 0.543 rs13042351 chr20:33238573 G/A cg08999081 chr20:33150536 PIGU -0.41 -7.64 -0.39 2.27e-13 Glomerular filtration rate (creatinine); LUSC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.83 -0.35 4.04e-11 Intelligence (multi-trait analysis); LUSC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg01191920 chr7:158217561 PTPRN2 0.57 11.95 0.55 1.26e-27 Obesity-related traits; LUSC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.61 0.62 1.05e-37 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7582180 0.629 rs2309796 chr2:100954385 C/T cg08017756 chr2:100939284 LONRF2 -0.45 -8.35 -0.42 1.82e-15 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.03 0.31 4.27e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg06454157 chr6:167490870 NA -0.25 -5.96 -0.31 6.44e-9 Crohn's disease; LUSC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg18225595 chr11:63971243 STIP1 0.65 11.21 0.52 5.79e-25 Platelet count; LUSC cis rs139156536 1 rs139156536 chr17:38164432 TTTTA/T cg26162295 chr17:38119207 GSDMA -0.27 -6.52 -0.34 2.53e-10 Lymphocyte percentage of white cells; LUSC cis rs11971779 0.584 rs6942519 chr7:139070090 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs4077515 0.967 rs4266763 chr9:139289825 C/T cg14169450 chr9:139327907 INPP5E -0.42 -7.4 -0.38 1.09e-12 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg22823121 chr1:150693482 HORMAD1 -0.45 -6.7 -0.34 8.88e-11 Tonsillectomy; LUSC cis rs1568889 1.000 rs16917687 chr11:28062614 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.51 0.46 3.95e-19 Bipolar disorder; LUSC cis rs13006833 0.668 rs291458 chr2:191181481 A/C cg21644426 chr2:191273491 MFSD6 0.43 6.14 0.32 2.39e-9 Urinary metabolites; LUSC cis rs617219 0.819 rs2607140 chr5:78563227 C/T cg24856658 chr5:78533917 JMY -0.31 -6.02 -0.31 4.68e-9 Betaine levels in individuals undergoing cardiac evaluation; LUSC trans rs11700980 0.551 rs2832033 chr21:30114841 C/T cg14791747 chr16:20752902 THUMPD1 0.55 6.05 0.31 3.8e-9 QRS complex (12-leadsum); LUSC trans rs28735056 0.935 rs537962 chr18:77592660 C/G cg05926928 chr17:57297772 GDPD1 0.47 6.61 0.34 1.51e-10 Schizophrenia; LUSC cis rs9560113 0.960 rs61967677 chr13:112174044 A/G cg14154082 chr13:112174009 NA 0.38 7.95 0.4 2.97e-14 Menarche (age at onset); LUSC cis rs4906332 1.000 rs35126287 chr14:103959432 A/G cg04998671 chr14:104000505 TRMT61A -0.45 -7.16 -0.36 5.08e-12 Coronary artery disease; LUSC cis rs654950 0.806 rs941971 chr1:42040893 T/C cg06885757 chr1:42089581 HIVEP3 -0.43 -8.58 -0.42 3.72e-16 Airway imaging phenotypes; LUSC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg04025307 chr7:1156635 C7orf50 0.43 6.65 0.34 1.22e-10 Longevity;Endometriosis; LUSC cis rs12540874 0.522 rs4947641 chr7:50489038 C/T cg18232548 chr7:50535776 DDC -0.61 -9.39 -0.46 9.89e-19 Systemic sclerosis; LUSC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg05340658 chr4:99064831 C4orf37 0.65 11.18 0.52 7.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4845570 0.831 rs11588258 chr1:151780728 A/T cg07092448 chr1:151763213 TDRKH -1.18 -12.38 -0.56 3.07e-29 Coronary artery disease; LUSC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg18681998 chr4:17616180 MED28 0.92 18.07 0.7 2.15e-51 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6460942 0.908 rs73677573 chr7:12283598 G/A cg06484146 chr7:12443880 VWDE -0.55 -5.85 -0.3 1.18e-8 Coronary artery disease; LUSC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg20891283 chr12:69753455 YEATS4 0.67 11.29 0.53 2.84e-25 Blood protein levels; LUSC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg11062466 chr8:58055876 NA 0.54 7.32 0.37 1.85e-12 Developmental language disorder (linguistic errors); LUSC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.78 0.35 5.37e-11 Platelet count; LUSC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg11812906 chr14:75593930 NEK9 -0.64 -10.98 -0.51 3.89e-24 Height; LUSC cis rs865483 0.861 rs56186148 chr17:35768827 T/A cg06716730 chr17:35851459 DUSP14 -0.26 -5.67 -0.3 3.15e-8 Monocyte count; LUSC cis rs9467773 0.620 rs2451711 chr6:26663110 A/G cg09904177 chr6:26538194 HMGN4 0.66 11.69 0.54 1.09e-26 Intelligence (multi-trait analysis); LUSC trans rs2204008 0.775 rs8186812 chr12:38305055 C/T cg06521331 chr12:34319734 NA -0.41 -6.31 -0.33 8.87e-10 Bladder cancer; LUSC cis rs8060686 0.516 rs9938020 chr16:68251784 C/G cg05110241 chr16:68378359 PRMT7 -0.51 -6.42 -0.33 4.73e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg11812906 chr14:75593930 NEK9 -0.64 -11.2 -0.52 5.95e-25 Height; LUSC cis rs6084875 0.840 rs2077519 chr20:4720750 A/G cg07258627 chr20:4721683 PRNT -0.34 -6.2 -0.32 1.69e-9 Systemic lupus erythematosus; LUSC cis rs2820315 1.000 rs2820315 chr1:201872264 A/G cg10061532 chr1:201886748 LMOD1 -0.26 -5.8 -0.3 1.57e-8 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; LUSC cis rs9300255 0.602 rs1727314 chr12:123640664 C/A cg05973401 chr12:123451056 ABCB9 0.54 6.67 0.34 1.06e-10 Neutrophil percentage of white cells; LUSC cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg04944784 chr2:26401820 FAM59B -0.7 -9.74 -0.47 6.73e-20 Gut microbiome composition (summer); LUSC trans rs7726839 0.540 rs72703087 chr5:598029 C/T cg25482853 chr8:67687455 SGK3 1.12 15.85 0.66 1.36e-42 Obesity-related traits; LUSC cis rs12188164 0.580 rs2672755 chr5:457249 G/T cg00049323 chr5:472564 LOC25845 0.52 7.99 0.4 2.28e-14 Cystic fibrosis severity; LUSC trans rs11098499 0.866 rs12513310 chr4:120288039 T/A cg25214090 chr10:38739885 LOC399744 0.49 7.49 0.38 6.22e-13 Corneal astigmatism; LUSC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg13119609 chr19:45449297 APOC2 0.47 9.46 0.46 5.65e-19 Blood protein levels; LUSC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -9.06 -0.44 1.11e-17 Monocyte percentage of white cells; LUSC cis rs34891900 0.507 rs2535679 chr22:18202850 A/G cg08824373 chr22:18117835 NA -0.41 -6.2 -0.32 1.66e-9 Sum neutrophil eosinophil counts; LUSC cis rs6545883 0.965 rs2305156 chr2:61729268 T/C cg15711740 chr2:61764176 XPO1 -0.49 -7.72 -0.39 1.34e-13 Tuberculosis; LUSC cis rs12210905 0.925 rs12193463 chr6:26961882 T/G cg23155468 chr6:27110703 HIST1H2BK -0.68 -5.93 -0.31 7.67e-9 Hip circumference adjusted for BMI; LUSC cis rs61931739 0.534 rs11052979 chr12:34035774 G/T cg06521331 chr12:34319734 NA -0.48 -7.71 -0.39 1.43e-13 Morning vs. evening chronotype; LUSC cis rs2639990 1.000 rs2639990 chr18:72915551 T/C cg02750262 chr18:72916776 ZADH2 0.67 7.45 0.38 7.8e-13 Vascular endothelial growth factor levels; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg17192681 chr2:10953115 PDIA6 0.39 6.22 0.32 1.45e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg10295955 chr4:187884368 NA -1.07 -25.94 -0.82 4.9e-82 Lobe attachment (rater-scored or self-reported); LUSC cis rs2677744 0.626 rs11854429 chr15:91489685 C/T cg23684204 chr15:91497937 RCCD1 -0.5 -7.05 -0.36 1.02e-11 Attention deficit hyperactivity disorder; LUSC cis rs56146971 0.763 rs2064961 chr14:91868814 A/G cg10511902 chr14:91842949 CCDC88C 0.44 5.82 0.3 1.37e-8 Alzheimer disease and age of onset; LUSC cis rs10771431 0.817 rs17202253 chr12:9361850 A/G cg08997352 chr12:9597637 DDX12 -0.72 -11.4 -0.53 1.17e-25 Breast size; LUSC cis rs12971120 0.891 rs2278158 chr18:72178300 G/T cg25817165 chr18:72167213 CNDP2 -0.7 -8.33 -0.41 2.15e-15 Refractive error; LUSC cis rs367615 0.552 rs2115511 chr5:108725403 A/T cg17395555 chr5:108820864 NA -0.46 -8.06 -0.4 1.36e-14 Colorectal cancer (SNP x SNP interaction); LUSC cis rs662064 0.889 rs1188526 chr1:10549848 G/C cg20482658 chr1:10539492 PEX14 -0.34 -6.9 -0.35 2.69e-11 Asthma; LUSC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg06008330 chr7:65541103 ASL 0.41 6.32 0.33 8.55e-10 Aortic root size; LUSC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs57590327 0.503 rs13080520 chr3:81850742 T/C cg07356753 chr3:81810745 GBE1 -0.55 -8.3 -0.41 2.54e-15 Extraversion; LUSC cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.43 -0.46 7.28e-19 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs9914988 0.943 rs9890155 chr17:27125467 A/G cg09479241 chr17:27052676 TLCD1 0.42 5.71 0.3 2.46e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs9467773 0.526 rs10946817 chr6:26364056 C/T cg05738196 chr6:26577821 NA -0.47 -7.31 -0.37 2.04e-12 Intelligence (multi-trait analysis); LUSC cis rs73193808 0.627 rs73192202 chr21:30520578 A/G cg24692254 chr21:30365293 RNF160 0.71 6.43 0.33 4.47e-10 Coronary artery disease; LUSC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.53 8.73 0.43 1.22e-16 Prudent dietary pattern; LUSC cis rs6681460 0.932 rs2044399 chr1:67054080 T/C cg02459107 chr1:67143332 SGIP1 0.46 8.43 0.42 1.04e-15 Presence of antiphospholipid antibodies; LUSC cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.73 0.35 7.22e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9322193 1.000 rs9377229 chr6:149928791 C/T cg07701084 chr6:150067640 NUP43 0.51 7.71 0.39 1.45e-13 Lung cancer; LUSC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg25251562 chr2:3704773 ALLC 0.52 8.65 0.43 2.23e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 8.07 0.4 1.32e-14 Personality dimensions; LUSC cis rs921968 0.565 rs586194 chr2:219610433 A/G cg02176678 chr2:219576539 TTLL4 -0.56 -9.9 -0.48 2.05e-20 Mean corpuscular hemoglobin concentration; LUSC cis rs7927592 0.871 rs55953412 chr11:68328283 C/T cg01657329 chr11:68192670 LRP5 -0.4 -5.73 -0.3 2.28e-8 Total body bone mineral density; LUSC cis rs2637266 0.935 rs1907323 chr10:78336015 C/T cg18941641 chr10:78392320 NA 0.32 5.83 0.3 1.33e-8 Pulmonary function; LUSC cis rs7495132 0.526 rs60433006 chr15:91197475 C/T cg00756943 chr15:91208460 NA -0.4 -5.7 -0.3 2.69e-8 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs35146811 0.700 rs4729579 chr7:99780282 C/G cg13334819 chr7:99746414 C7orf59 -0.5 -6.67 -0.34 1.05e-10 Coronary artery disease; LUSC cis rs7584330 0.554 rs74001399 chr2:238445440 G/A cg16989719 chr2:238392110 NA -0.41 -5.88 -0.31 9.8e-9 Prostate cancer; LUSC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg08499158 chr17:42289980 UBTF 0.38 6.35 0.33 7.23e-10 Total body bone mineral density; LUSC cis rs9467773 0.967 rs9295694 chr6:26512994 A/T cg09904177 chr6:26538194 HMGN4 0.75 14.22 0.61 3.36e-36 Intelligence (multi-trait analysis); LUSC cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.8 -0.35 4.76e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg06675483 chr6:26987649 LOC100270746;C6orf41 0.29 5.82 0.3 1.37e-8 Autism spectrum disorder or schizophrenia; LUSC trans rs72674100 1.000 rs4434261 chr4:97963014 A/G cg16405019 chr1:18959625 PAX7 -0.57 -6.11 -0.32 2.78e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs3808502 0.525 rs13280813 chr8:11425105 G/T cg27411982 chr8:10470053 RP1L1 -0.46 -7.08 -0.36 8.74e-12 Neuroticism; LUSC cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg09640425 chr7:158790006 NA -0.49 -7.74 -0.39 1.21e-13 Facial morphology (factor 20); LUSC cis rs2486288 0.656 rs6493143 chr15:45570781 G/T cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.7 -0.39 1.6e-13 Glomerular filtration rate; LUSC cis rs7264396 0.635 rs6121073 chr20:34457513 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -8.01 -0.4 1.96e-14 Total cholesterol levels; LUSC cis rs7107174 1.000 rs4945261 chr11:77990260 A/G cg02023728 chr11:77925099 USP35 -0.47 -6.73 -0.35 7.24e-11 Testicular germ cell tumor; LUSC cis rs9326248 0.768 rs4936366 chr11:117026885 G/A cg16524733 chr11:117070046 TAGLN 0.36 5.71 0.3 2.47e-8 Blood protein levels; LUSC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg00376283 chr12:123451042 ABCB9 0.66 8.22 0.41 4.69e-15 Height;Educational attainment;Head circumference (infant); LUSC cis rs765787 0.530 rs12323957 chr15:45490773 C/T cg24006582 chr15:45444508 DUOX1 0.71 10.23 0.49 1.46e-21 Uric acid levels; LUSC cis rs9303401 0.659 rs62083436 chr17:57031742 G/A cg25039879 chr17:56429692 SUPT4H1 0.69 9.12 0.45 7.14e-18 Cognitive test performance; LUSC cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg08999081 chr20:33150536 PIGU -0.53 -10.48 -0.5 2.14e-22 Glomerular filtration rate (creatinine); LUSC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg03517284 chr6:25882590 NA -0.44 -7.38 -0.37 1.26e-12 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.754 rs1980026 chr4:120251643 C/A cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.53e-10 Corneal astigmatism; LUSC cis rs2281845 0.859 rs4915216 chr1:201077469 T/G cg22815214 chr1:201083145 CACNA1S 0.53 9.17 0.45 5.08e-18 Permanent tooth development; LUSC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg23630131 chr7:65973040 NA 0.21 5.81 0.3 1.42e-8 Aortic root size; LUSC cis rs921665 0.831 rs6548167 chr2:3181062 A/G cg02624386 chr2:3182749 NA 0.57 6.31 0.33 8.85e-10 World class endurance athleticism; LUSC cis rs6700896 0.522 rs4655778 chr1:66142336 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.51 6.03 0.31 4.25e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg00745463 chr17:30367425 LRRC37B -0.7 -8.57 -0.42 3.92e-16 Hip circumference adjusted for BMI; LUSC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg20307385 chr11:47447363 PSMC3 -0.48 -6.12 -0.32 2.67e-9 Subjective well-being; LUSC cis rs7647973 0.710 rs1532204 chr3:49609477 C/G cg07636037 chr3:49044803 WDR6 0.55 5.69 0.3 2.82e-8 Menarche (age at onset); LUSC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg16240275 chr20:61666158 NCRNA00029 0.41 9.22 0.45 3.5e-18 Prostate cancer (SNP x SNP interaction); LUSC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg20203395 chr5:56204925 C5orf35 -0.75 -10.33 -0.49 6.65e-22 Initial pursuit acceleration; LUSC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg26441486 chr22:50317300 CRELD2 0.52 7.91 0.4 3.74e-14 Schizophrenia; LUSC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg22823121 chr1:150693482 HORMAD1 0.54 8.44 0.42 9.59e-16 Tonsillectomy; LUSC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg24675056 chr1:15929824 NA 0.47 8.23 0.41 4.38e-15 Systolic blood pressure; LUSC cis rs870825 0.616 rs55674580 chr4:185626605 C/G cg04058563 chr4:185651563 MLF1IP 0.87 13.25 0.59 1.77e-32 Blood protein levels; LUSC cis rs854765 0.583 rs11078404 chr17:17820487 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.1 0.58 6.37e-32 Total body bone mineral density; LUSC cis rs559928 0.556 rs734762 chr11:63912189 G/C cg24687543 chr11:63912206 MACROD1 0.47 5.96 0.31 6.34e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg19468946 chr17:37922297 IKZF3 -0.45 -7.08 -0.36 8.37e-12 Self-reported allergy; LUSC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg00339695 chr16:24857497 SLC5A11 0.6 9.59 0.46 2.1e-19 Intelligence (multi-trait analysis); LUSC trans rs7916697 0.540 rs4551651 chr10:70024529 A/G cg04882175 chr6:131122610 NA -0.48 -6.55 -0.34 2.18e-10 Optic disc area; LUSC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.99 0.4 2.24e-14 Prudent dietary pattern; LUSC trans rs7737355 1.000 rs7719126 chr5:130613749 T/C cg07715041 chr7:99302981 CYP3A7 -0.39 -6.14 -0.32 2.3e-9 Life satisfaction; LUSC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg27432699 chr2:27873401 GPN1 -0.57 -8.46 -0.42 8.53e-16 Total body bone mineral density; LUSC cis rs6700896 0.500 rs7549647 chr1:66088184 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.54 6.31 0.33 8.83e-10 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg13798780 chr7:105162888 PUS7 0.58 6.32 0.33 8.2e-10 Bipolar disorder (body mass index interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09898138 chr12:120426550 CCDC64 0.45 6.02 0.31 4.67e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7618501 0.602 rs2071207 chr3:50159844 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.19 -0.45 4.18e-18 Intelligence (multi-trait analysis); LUSC trans rs11098499 0.909 rs28884220 chr4:120307211 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.02 0.4 1.87e-14 Corneal astigmatism; LUSC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15541040 chr2:3486749 NA -0.56 -9.07 -0.44 1.04e-17 Neurofibrillary tangles; LUSC cis rs459571 0.959 rs2520099 chr9:136918139 T/C cg01294253 chr9:136912663 BRD3 0.34 6.03 0.31 4.34e-9 Platelet distribution width; LUSC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.58 -0.34 1.81e-10 Lung cancer; LUSC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.15 0.32 2.17e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9527 0.590 rs12415199 chr10:104895536 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg22676075 chr6:135203613 NA 0.55 8.77 0.43 9.23e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.85 12.22 0.56 1.22e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26994227 chr5:130971071 RAPGEF6 -0.59 -6.97 -0.36 1.67e-11 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.966 rs2854161 chr17:61976093 T/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.47 -6.93 -0.35 2.12e-11 Prudent dietary pattern; LUSC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg05084668 chr3:125655381 ALG1L -0.49 -7.01 -0.36 1.33e-11 Blood pressure (smoking interaction); LUSC cis rs4595586 0.505 rs11615603 chr12:39409450 C/G cg26384229 chr12:38710491 ALG10B 0.5 7.24 0.37 3.16e-12 Morning vs. evening chronotype; LUSC cis rs4843185 0.576 rs380996 chr16:85728813 A/G cg26571870 chr16:85723150 GINS2 0.34 6.52 0.34 2.57e-10 Platelet distribution width; LUSC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.41 0.56 2.39e-29 Prudent dietary pattern; LUSC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg25072359 chr17:41440525 NA 0.63 8.9 0.44 3.61e-17 Menopause (age at onset); LUSC cis rs4845875 0.530 rs6667720 chr1:11831615 A/G cg14194983 chr1:11908298 NPPA -0.32 -5.73 -0.3 2.19e-8 Midregional pro atrial natriuretic peptide levels; LUSC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg04518342 chr5:131593106 PDLIM4 0.55 10.41 0.49 3.66e-22 Acylcarnitine levels; LUSC cis rs981844 0.890 rs62325115 chr4:154694847 A/G cg14289246 chr4:154710475 SFRP2 0.54 6.81 0.35 4.52e-11 Response to statins (LDL cholesterol change); LUSC cis rs11758351 1.000 rs1341759 chr6:26195502 G/A cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg01879757 chr17:41196368 BRCA1 -0.5 -7.93 -0.4 3.29e-14 Menopause (age at onset); LUSC cis rs875971 0.660 rs10229345 chr7:65982168 G/C cg12463550 chr7:65579703 CRCP 0.47 6.77 0.35 5.98e-11 Aortic root size; LUSC cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg00409905 chr10:38381863 ZNF37A -0.36 -6.17 -0.32 2.03e-9 Extrinsic epigenetic age acceleration; LUSC cis rs4776059 0.798 rs4774634 chr15:52872488 G/C cg22715398 chr15:52968154 KIAA1370 -0.63 -8.48 -0.42 7.43e-16 Schizophrenia; LUSC cis rs11098499 0.779 rs6815934 chr4:120267310 T/C cg09307838 chr4:120376055 NA 0.64 9.64 0.47 1.4e-19 Corneal astigmatism; LUSC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg13206674 chr6:150067644 NUP43 0.6 9.38 0.46 1.07e-18 Lung cancer; LUSC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -6.49 -0.33 3.04e-10 Developmental language disorder (linguistic errors); LUSC cis rs2439831 0.681 rs498837 chr15:43608024 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.93 11.22 0.52 5.35e-25 Lung cancer in ever smokers; LUSC cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg02153584 chr22:29168773 CCDC117 0.6 8.79 0.43 8.24e-17 Lymphocyte counts; LUSC cis rs8060686 0.641 rs8044014 chr16:68209872 T/C cg27539214 chr16:67997921 SLC12A4 -0.5 -6.72 -0.35 7.83e-11 HDL cholesterol;Metabolic syndrome; LUSC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06500355 chr6:111804104 REV3L 0.52 6.26 0.32 1.22e-9 Intelligence (multi-trait analysis); LUSC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg24675658 chr1:53192096 ZYG11B -0.59 -9.23 -0.45 3.2e-18 Monocyte count; LUSC cis rs6599077 1.000 rs59425991 chr3:40089986 C/A cg13683864 chr3:40499215 RPL14 -0.59 -7.63 -0.39 2.51e-13 Sleep-related phenotypes; LUSC cis rs9378688 0.654 rs2505660 chr6:2326441 A/G cg12303981 chr6:2244766 GMDS -0.41 -5.79 -0.3 1.63e-8 Caudate nucleus volume; LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg18099408 chr3:52552593 STAB1 -0.42 -7.15 -0.36 5.38e-12 Bipolar disorder; LUSC cis rs1003719 0.680 rs2257091 chr21:38522618 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.35 -0.49 5.87e-22 Eye color traits; LUSC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg20476274 chr7:133979776 SLC35B4 0.87 16.93 0.68 7.19e-47 Mean platelet volume; LUSC cis rs72960926 0.744 rs72952273 chr6:74926284 C/T cg03266952 chr6:74778945 NA -0.73 -6.47 -0.33 3.56e-10 Metabolite levels (MHPG); LUSC cis rs11055008 0.620 rs12816452 chr12:12833006 A/T cg09462578 chr12:12878428 APOLD1 -0.43 -6.58 -0.34 1.78e-10 Pulse pressure; LUSC cis rs6486730 1.000 rs6486730 chr12:129275027 C/T cg09035930 chr12:129282057 SLC15A4 0.52 9.45 0.46 6.29e-19 Systemic lupus erythematosus; LUSC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.89 0.48 2.14e-20 Bipolar disorder; LUSC cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg21427119 chr20:30132790 HM13 -0.36 -5.65 -0.3 3.35e-8 Mean corpuscular hemoglobin; LUSC cis rs4663866 0.908 rs2304670 chr2:239165636 C/T cg16914508 chr2:239161102 PER2 0.67 7.23 0.37 3.26e-12 Irritable bowel syndrome; LUSC trans rs2490361 1.000 rs2490361 chr1:237326974 C/T cg15653282 chr18:11689218 GNAL 0.39 5.98 0.31 5.86e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 16.07 0.66 1.94e-43 Platelet count; LUSC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg10018233 chr7:150070692 REPIN1 0.39 7.1 0.36 7.54e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs7523273 0.606 rs2724380 chr1:207949682 C/T cg22525895 chr1:207977042 MIR29B2 0.42 6.72 0.35 7.81e-11 Schizophrenia; LUSC cis rs295137 0.799 rs4145969 chr2:201139961 C/T cg23649088 chr2:200775458 C2orf69 -0.38 -5.9 -0.31 8.78e-9 Asthma (bronchodilator response); LUSC cis rs72960926 0.744 rs1817735 chr6:74980974 T/C cg03266952 chr6:74778945 NA -0.87 -7.19 -0.37 4.34e-12 Metabolite levels (MHPG); LUSC cis rs12956009 0.558 rs12960592 chr18:44857203 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.27 0.32 1.09e-9 Educational attainment (years of education); LUSC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg01475377 chr6:109611718 NA -0.39 -7.09 -0.36 7.95e-12 Reticulocyte fraction of red cells; LUSC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg11062466 chr8:58055876 NA 0.65 8.48 0.42 7.17e-16 Developmental language disorder (linguistic errors); LUSC cis rs10791097 0.694 rs4436551 chr11:130755739 A/G cg12179176 chr11:130786555 SNX19 -0.86 -15.12 -0.64 1.07e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg07507251 chr3:52567010 NT5DC2 -0.31 -6.39 -0.33 5.66e-10 Electroencephalogram traits; LUSC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg22029157 chr1:209979665 IRF6 0.76 11.32 0.53 2.24e-25 Cleft lip with or without cleft palate; LUSC cis rs10504229 0.679 rs16921688 chr8:58054659 T/C cg21724239 chr8:58056113 NA 0.67 7.43 0.38 9.33e-13 Developmental language disorder (linguistic errors); LUSC cis rs240764 0.658 rs9399694 chr6:101257877 A/G cg09795085 chr6:101329169 ASCC3 -0.46 -6.51 -0.34 2.71e-10 Neuroticism; LUSC cis rs17621444 0.522 rs4752369 chr10:121775790 G/A cg02041677 chr10:121771263 NA -0.34 -6.47 -0.33 3.53e-10 IgG glycosylation; LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg26304593 chr6:42947056 PEX6 -0.52 -7.89 -0.4 4.47e-14 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg24531977 chr5:56204891 C5orf35 -1.17 -18.09 -0.7 1.88e-51 Initial pursuit acceleration; LUSC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg22437258 chr11:111473054 SIK2 0.53 7.53 0.38 4.93e-13 Primary sclerosing cholangitis; LUSC cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg19378624 chr17:45501242 LOC100272146;C17orf57 0.38 6.49 0.33 3.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs12618769 0.597 rs4850874 chr2:99069799 G/A cg10123293 chr2:99228465 UNC50 0.45 7.58 0.38 3.33e-13 Bipolar disorder; LUSC cis rs4595586 0.679 rs1356264 chr12:39393754 A/T cg26384229 chr12:38710491 ALG10B 0.43 5.93 0.31 7.46e-9 Morning vs. evening chronotype; LUSC cis rs9472414 0.771 rs562016 chr6:44780978 G/A cg20913747 chr6:44695427 NA -0.4 -5.77 -0.3 1.85e-8 Height; LUSC cis rs12760731 0.582 rs9803679 chr1:178410425 T/C cg00404053 chr1:178313656 RASAL2 0.48 5.76 0.3 1.91e-8 Obesity-related traits; LUSC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg03517284 chr6:25882590 NA -0.51 -9.58 -0.46 2.35e-19 Blood metabolite levels; LUSC cis rs12543645 0.598 rs35338507 chr8:10277982 G/A cg12940923 chr8:10282607 MSRA 0.41 7.12 0.36 6.83e-12 Schizophrenia; LUSC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.7 -0.34 9.03e-11 Mean platelet volume; LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg04944784 chr2:26401820 FAM59B -0.74 -10.92 -0.51 6.22e-24 Gut microbiome composition (summer); LUSC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.39 6.53 0.34 2.41e-10 Electroencephalogram traits; LUSC cis rs9902453 0.904 rs10853136 chr17:28406018 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.67 -10.64 -0.5 5.77e-23 Coffee consumption (cups per day); LUSC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg15921436 chr17:44337874 NA 0.73 11.08 0.52 1.63e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -6.0 -0.31 5.15e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6546550 0.658 rs10186725 chr2:70015491 A/G cg02498382 chr2:70120550 SNRNP27 -0.25 -6.1 -0.32 2.93e-9 Prevalent atrial fibrillation; LUSC cis rs11122272 0.735 rs2486737 chr1:231520523 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg22143856 chr6:28129313 ZNF389 0.41 5.68 0.3 2.98e-8 Parkinson's disease; LUSC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg11752832 chr7:134001865 SLC35B4 0.56 8.8 0.43 7.57e-17 Mean platelet volume; LUSC cis rs62103177 0.525 rs9949598 chr18:77753037 G/A cg02751453 chr18:77725136 HSBP1L1 0.41 5.73 0.3 2.25e-8 Opioid sensitivity; LUSC cis rs7312933 0.531 rs1796380 chr12:42791543 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.48 -6.83 -0.35 3.95e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC trans rs11148252 0.740 rs7981050 chr13:52755149 C/T cg18335740 chr13:41363409 SLC25A15 0.5 7.8 0.39 7.81e-14 Lewy body disease; LUSC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg22166914 chr1:53195759 ZYG11B 0.7 12.05 0.55 5.41e-28 Monocyte count; LUSC cis rs1865721 0.771 rs4622605 chr18:73139008 T/C cg26385618 chr18:73139727 C18orf62 -0.55 -10.11 -0.48 3.98e-21 Intelligence; LUSC cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg01884057 chr2:25150051 NA 0.48 11.42 0.53 1e-25 Body mass index; LUSC cis rs34779708 0.742 rs35912711 chr10:35312996 T/C cg03585969 chr10:35415529 CREM 0.6 8.74 0.43 1.12e-16 Inflammatory bowel disease;Crohn's disease; LUSC cis rs13401104 0.796 rs10929172 chr2:237116600 C/G cg19324714 chr2:237145437 ASB18 0.43 5.65 0.3 3.43e-8 Educational attainment; LUSC cis rs3736594 0.513 rs62138968 chr2:27824485 C/G cg27432699 chr2:27873401 GPN1 0.65 8.74 0.43 1.17e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg03929089 chr4:120376271 NA -1.04 -20.1 -0.74 1.79e-59 Height; LUSC cis rs9467773 0.620 rs2101581 chr6:26622769 G/T cg11502198 chr6:26597334 ABT1 0.72 12.09 0.55 3.67e-28 Intelligence (multi-trait analysis); LUSC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg26597838 chr10:835615 NA 0.97 13.27 0.59 1.45e-32 Eosinophil percentage of granulocytes; LUSC cis rs644799 0.511 rs1016030 chr11:95472693 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.9 0.48 1.98e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs8028313 0.630 rs7169086 chr15:67934454 C/T cg24579218 chr15:68104479 NA -0.39 -6.7 -0.34 8.86e-11 Obesity; LUSC cis rs72772090 0.539 rs11747896 chr5:96113397 A/G cg17330273 chr5:96107758 CAST;ERAP1 0.68 7.04 0.36 1.1e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1348850 0.602 rs1453373 chr2:178221668 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.42 5.75 0.3 1.98e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs854765 0.583 rs11656840 chr17:17837354 C/T cg16928487 chr17:17741425 SREBF1 -0.43 -8.55 -0.42 4.5e-16 Total body bone mineral density; LUSC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg10130564 chr11:117069849 TAGLN -0.39 -6.64 -0.34 1.24e-10 Blood protein levels; LUSC cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.13 0.36 6.11e-12 Cognitive ability; LUSC cis rs2012796 0.872 rs59397507 chr14:81821334 A/G cg02996355 chr14:81879375 NA 0.51 7.22 0.37 3.62e-12 Night sleep phenotypes; LUSC trans rs657452 0.722 rs1494461 chr1:49787196 A/G cg02399189 chr10:45470562 RASSF4 0.42 6.14 0.32 2.31e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg22782873 chr19:19639568 YJEFN3 -0.51 -6.05 -0.31 3.78e-9 Bipolar disorder; LUSC cis rs2324229 0.861 rs1180198 chr6:83959048 C/T cg08257003 chr6:84140564 ME1 0.27 5.92 0.31 7.93e-9 Platelet-derived growth factor BB levels; LUSC cis rs950169 0.922 rs11633075 chr15:85113972 C/A cg12863693 chr15:85201151 NMB 0.34 6.82 0.35 4.35e-11 Schizophrenia; LUSC cis rs4474465 0.850 rs4944203 chr11:78220629 A/C cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg24692254 chr21:30365293 RNF160 -0.84 -15.34 -0.64 1.37e-40 Dental caries; LUSC cis rs2692947 0.770 rs11689832 chr2:96554851 A/C cg22654517 chr2:96458247 NA 0.37 6.92 0.35 2.38e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs2219968 0.676 rs55878309 chr8:78839853 A/G cg00738934 chr8:78996279 NA -0.35 -5.94 -0.31 6.98e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs6951245 1.000 rs76214082 chr7:1102097 T/A cg13565492 chr6:43139072 SRF -0.62 -6.6 -0.34 1.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11051970 0.918 rs325417 chr12:32574217 A/G cg02745156 chr12:32552066 NA 0.43 7.32 0.37 1.84e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg04865166 chr7:105162814 PUS7 0.51 5.69 0.3 2.84e-8 Bipolar disorder (body mass index interaction); LUSC cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg08999081 chr20:33150536 PIGU 0.36 6.68 0.34 9.88e-11 Height; LUSC cis rs6121246 0.567 rs6060399 chr20:30220823 C/T cg18721089 chr20:30220636 NA -0.39 -6.08 -0.32 3.28e-9 Mean corpuscular hemoglobin; LUSC cis rs8114671 0.967 rs9574 chr20:33764632 C/G cg24642439 chr20:33292090 TP53INP2 0.41 6.0 0.31 5.07e-9 Height; LUSC cis rs7829975 0.514 rs2945873 chr8:8260445 C/T cg06636001 chr8:8085503 FLJ10661 0.67 11.29 0.53 3.02e-25 Mood instability; LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg10802521 chr3:52805072 NEK4 -0.54 -8.63 -0.43 2.6e-16 Bipolar disorder; LUSC cis rs711244 0.748 rs11124555 chr2:37176213 G/A cg14987922 chr2:37194071 STRN 0.42 6.15 0.32 2.22e-9 Mean platelet volume; LUSC cis rs477692 0.673 rs511361 chr10:131365052 C/T cg26102564 chr10:131424627 MGMT 0.42 6.33 0.33 7.79e-10 Response to temozolomide; LUSC cis rs11025559 0.773 rs16906274 chr11:20470142 T/C cg19653624 chr11:20408972 PRMT3 -0.67 -8.44 -0.42 9.97e-16 Pursuit maintenance gain; LUSC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg00800038 chr16:89945340 TCF25 -0.75 -6.56 -0.34 2.08e-10 Skin colour saturation; LUSC cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 8.41 0.42 1.25e-15 Menarche (age at onset); LUSC cis rs2299587 0.527 rs7843715 chr8:17733526 C/A cg01800426 chr8:17659068 MTUS1 -0.39 -5.65 -0.3 3.43e-8 Economic and political preferences; LUSC cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg03146154 chr1:46216737 IPP -0.57 -8.28 -0.41 3e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs593982 1.000 rs56257941 chr11:65505641 C/T cg08755490 chr11:65554678 OVOL1 -1.46 -15.35 -0.64 1.35e-40 Atopic dermatitis; LUSC trans rs10028773 0.556 rs4473640 chr4:120260437 G/A cg25214090 chr10:38739885 LOC399744 0.41 6.29 0.33 9.72e-10 Educational attainment; LUSC cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg07606381 chr6:8435919 SLC35B3 0.74 12.55 0.57 7.61e-30 Motion sickness; LUSC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg06636001 chr8:8085503 FLJ10661 0.8 13.66 0.6 4.54e-34 Systolic blood pressure; LUSC trans rs2018683 0.803 rs12700920 chr7:28984924 A/G cg19402173 chr7:128379420 CALU -0.54 -8.6 -0.43 3.22e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.57 9.81 0.47 4.02e-20 Bipolar disorder; LUSC cis rs738322 0.967 rs2092180 chr22:38571563 A/G cg25457927 chr22:38595422 NA -0.42 -8.92 -0.44 3.05e-17 Cutaneous nevi; LUSC cis rs9403521 1.000 rs12528456 chr6:144003706 A/G cg18240653 chr6:144019428 PHACTR2 -0.51 -6.16 -0.32 2.11e-9 Obesity-related traits; LUSC cis rs9399401 0.633 rs1329705 chr6:142753338 G/A cg03128060 chr6:142623767 GPR126 0.51 8.35 0.42 1.8e-15 Chronic obstructive pulmonary disease; LUSC cis rs7584330 0.744 rs10929235 chr2:238380272 A/G cg16989719 chr2:238392110 NA -0.47 -7.19 -0.37 4.33e-12 Prostate cancer; LUSC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg20607287 chr7:12443886 VWDE -0.62 -6.2 -0.32 1.69e-9 Coronary artery disease; LUSC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg24531977 chr5:56204891 C5orf35 -1.05 -16.06 -0.66 2.08e-43 Initial pursuit acceleration; LUSC cis rs11098499 0.909 rs10014719 chr4:120320715 G/A cg09307838 chr4:120376055 NA 0.79 11.36 0.53 1.63e-25 Corneal astigmatism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg17144508 chr2:128283727 IWS1 -0.46 -5.98 -0.31 5.72e-9 Bipolar disorder and schizophrenia; LUSC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg25036284 chr2:26402008 FAM59B -0.76 -10.98 -0.52 3.69e-24 Gut microbiome composition (summer); LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg25387593 chr11:118927868 HYOU1 0.5 6.0 0.31 5.2e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs611744 0.523 rs13253581 chr8:109343105 A/G cg21045802 chr8:109455806 TTC35 0.5 7.8 0.39 8.14e-14 Dupuytren's disease; LUSC cis rs1853665 0.669 rs4368824 chr6:150269299 T/A cg04697775 chr6:150285333 ULBP1 0.52 5.67 0.3 3.11e-8 Radiation response; LUSC cis rs453301 0.719 rs34004903 chr8:8892604 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.67 -0.39 1.89e-13 Joint mobility (Beighton score); LUSC cis rs6665290 0.935 rs6704144 chr1:227201030 C/G cg10327440 chr1:227177885 CDC42BPA -1.11 -24.66 -0.8 3.21e-77 Myeloid white cell count; LUSC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.84 12.98 0.58 1.83e-31 Cognitive test performance; LUSC cis rs11018904 0.861 rs4589254 chr11:89963355 A/C cg26028595 chr11:89956573 CHORDC1 0.49 5.86 0.31 1.12e-8 Intelligence (multi-trait analysis); LUSC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg11764359 chr7:65958608 NA 0.68 10.96 0.51 4.39e-24 Aortic root size; LUSC cis rs7089973 0.624 rs10885614 chr10:116609098 C/T cg03647239 chr10:116582469 FAM160B1 0.44 7.15 0.36 5.58e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg08219700 chr8:58056026 NA 0.72 8.47 0.42 8.07e-16 Developmental language disorder (linguistic errors); LUSC cis rs8062405 0.895 rs62036658 chr16:28850371 T/G cg09754948 chr16:28834200 ATXN2L 0.4 5.66 0.3 3.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs12464483 0.591 rs2602775 chr2:30883012 C/T cg12454169 chr2:30669597 LCLAT1 0.63 8.54 0.42 4.91e-16 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg23158103 chr7:148848205 ZNF398 -0.49 -8.02 -0.4 1.74e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6782228 0.606 rs2712417 chr3:128345179 A/G cg16766828 chr3:128327626 NA -0.31 -5.66 -0.3 3.3e-8 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; LUSC cis rs1160297 0.609 rs10203699 chr2:53105568 A/G cg07782112 chr2:53107842 NA 0.39 6.62 0.34 1.45e-10 Hemostatic factors and hematological phenotypes; LUSC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg17724175 chr1:150552817 MCL1 0.36 6.53 0.34 2.45e-10 Tonsillectomy; LUSC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.47 -6.74 -0.35 7.05e-11 Platelet count; LUSC cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg22681709 chr2:178499509 PDE11A -0.58 -11.37 -0.53 1.48e-25 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC trans rs61931739 0.620 rs1905241 chr12:33709729 G/A cg26384229 chr12:38710491 ALG10B -0.42 -6.03 -0.31 4.32e-9 Morning vs. evening chronotype; LUSC cis rs909674 0.731 rs6001594 chr22:39837472 C/T cg02038168 chr22:39784481 NA -0.44 -6.59 -0.34 1.75e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs3096299 0.702 rs2086825 chr16:89471542 C/T cg06640241 chr16:89574553 SPG7 0.52 7.85 0.39 5.86e-14 Multiple myeloma (IgH translocation); LUSC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg05368731 chr17:41323189 NBR1 0.93 15.97 0.66 4.83e-43 Menopause (age at onset); LUSC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.64 0.5 5.84e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11249608 0.548 rs12152869 chr5:178462520 A/G cg21905437 chr5:178450457 ZNF879 0.43 5.67 0.3 3.1e-8 Pubertal anthropometrics; LUSC cis rs2688608 0.967 rs9971040 chr10:75661162 G/C cg23231163 chr10:75533350 FUT11 -0.37 -5.96 -0.31 6.29e-9 Inflammatory bowel disease; LUSC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg13010344 chr12:123464640 ARL6IP4 0.41 6.31 0.33 8.93e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg18758796 chr5:131593413 PDLIM4 0.38 6.48 0.33 3.29e-10 Breast cancer; LUSC cis rs7615316 0.528 rs75274088 chr3:142337804 G/A cg16271453 chr3:142027066 XRN1 -0.45 -7.9 -0.4 4.21e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 7.03 0.36 1.18e-11 Multiple sclerosis; LUSC cis rs12594515 1.000 rs8027000 chr15:45987795 T/C cg01629716 chr15:45996671 NA 0.4 6.09 0.32 3.17e-9 Waist circumference;Weight; LUSC trans rs11098499 0.738 rs34965784 chr4:120361586 G/C cg25214090 chr10:38739885 LOC399744 0.55 8.15 0.41 7.22e-15 Corneal astigmatism; LUSC cis rs4906332 1.000 rs55731474 chr14:103878481 G/A cg04998671 chr14:104000505 TRMT61A -0.47 -7.29 -0.37 2.23e-12 Coronary artery disease; LUSC cis rs75804782 0.641 rs72987327 chr2:239359833 T/G cg18131467 chr2:239335373 ASB1 -0.73 -6.63 -0.34 1.36e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg23711669 chr6:146136114 FBXO30 0.86 15.52 0.65 2.69e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg04166393 chr7:2884313 GNA12 0.41 5.66 0.3 3.19e-8 Height; LUSC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg06145435 chr7:1022769 CYP2W1 0.3 6.23 0.32 1.37e-9 Longevity;Endometriosis; LUSC cis rs11048434 0.661 rs34791180 chr12:9110919 T/C cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg26818010 chr10:134567672 INPP5A -0.86 -11.07 -0.52 1.83e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03934478 chr11:495069 RNH1 0.9 10.35 0.49 5.81e-22 Body mass index; LUSC cis rs4746822 0.954 rs5030937 chr10:70975897 C/T cg14418922 chr10:70824840 NA -0.38 -6.22 -0.32 1.47e-9 Glycemic traits (pregnancy); LUSC cis rs9326248 0.581 rs7121898 chr11:116796846 A/T cg01368799 chr11:117014884 PAFAH1B2 0.58 8.88 0.44 4.2e-17 Blood protein levels; LUSC cis rs6504663 0.596 rs7208018 chr17:48557863 C/T cg03168497 chr17:48586147 MYCBPAP -0.48 -6.44 -0.33 4.19e-10 Visceral fat; LUSC cis rs6494488 0.500 rs72742972 chr15:64934117 C/T cg08069370 chr15:64387884 SNX1 -0.66 -5.78 -0.3 1.7e-8 Coronary artery disease; LUSC cis rs4906332 1.000 rs12885762 chr14:103882200 C/A cg04998671 chr14:104000505 TRMT61A -0.46 -7.18 -0.37 4.47e-12 Coronary artery disease; LUSC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg00750074 chr16:89608354 SPG7 -0.45 -7.86 -0.4 5.41e-14 Multiple myeloma (IgH translocation); LUSC cis rs10089 1.000 rs7703634 chr5:127509223 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.49 0.53 5.61e-26 Ileal carcinoids; LUSC trans rs6598955 0.671 rs17163746 chr1:26564230 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.8 -0.43 7.56e-17 Obesity-related traits; LUSC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.26 -0.32 1.18e-9 Menopause (age at onset); LUSC cis rs4561483 0.801 rs33649 chr16:11979608 G/C cg08843971 chr16:11963173 GSPT1 -0.48 -7.13 -0.36 6.06e-12 Testicular germ cell tumor; LUSC cis rs2742540 0.505 rs2742493 chr11:8967592 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.36 6.48 0.33 3.27e-10 Hematocrit; LUSC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg15704280 chr7:45808275 SEPT13 -1.12 -24.88 -0.81 4.68e-78 Height; LUSC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg01802117 chr1:53393560 SCP2 -0.43 -7.19 -0.37 4.19e-12 Monocyte count; LUSC cis rs1178968 0.901 rs4717752 chr7:72754237 A/T cg25889504 chr7:72793014 NA 0.59 8.07 0.4 1.24e-14 Triglyceride levels; LUSC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg02423579 chr7:2872169 GNA12 -0.47 -6.63 -0.34 1.38e-10 Height; LUSC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg18225595 chr11:63971243 STIP1 -0.46 -5.68 -0.3 2.98e-8 Mean platelet volume; LUSC cis rs28374715 0.662 rs8038983 chr15:41473316 G/A cg18705301 chr15:41695430 NDUFAF1 -0.86 -15.36 -0.64 1.19e-40 Ulcerative colitis; LUSC cis rs10761482 0.769 rs10740024 chr10:62100840 G/A cg18175470 chr10:62150864 ANK3 -0.5 -7.15 -0.36 5.53e-12 Schizophrenia; LUSC trans rs61931739 0.500 rs11519398 chr12:34473553 C/T cg13010199 chr12:38710504 ALG10B 0.68 10.53 0.5 1.37e-22 Morning vs. evening chronotype; LUSC cis rs7481584 0.517 rs80872 chr11:3049984 G/T cg05729581 chr11:3078854 CARS 0.39 5.7 0.3 2.67e-8 Calcium levels; LUSC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg10523679 chr1:76189770 ACADM 0.9 16.2 0.66 5.81e-44 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10489202 1.000 rs275157 chr1:168064178 T/C cg24449463 chr1:168025552 DCAF6 -0.58 -7.16 -0.36 5.18e-12 Schizophrenia; LUSC cis rs11264213 0.901 rs72661628 chr1:36406547 A/G cg27506609 chr1:36549197 TEKT2 0.68 7.88 0.4 4.58e-14 Schizophrenia; LUSC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg08132940 chr7:1081526 C7orf50 -0.52 -6.22 -0.32 1.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg00074818 chr8:8560427 CLDN23 -0.57 -9.65 -0.47 1.39e-19 Obesity-related traits; LUSC cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg21724239 chr8:58056113 NA 0.76 8.2 0.41 5.29e-15 Developmental language disorder (linguistic errors); LUSC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg06618935 chr21:46677482 NA -0.39 -7.91 -0.4 3.72e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg16405210 chr4:1374714 KIAA1530 -0.65 -10.22 -0.49 1.62e-21 Longevity; LUSC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.13 16.21 0.66 5.12e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg15145296 chr3:125709740 NA -0.58 -6.56 -0.34 2.03e-10 Blood pressure (smoking interaction); LUSC cis rs9296092 0.538 rs7761268 chr6:33519300 C/T cg13560919 chr6:33536144 NA -0.82 -15.68 -0.65 6.59e-42 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs6502050 0.769 rs9898542 chr17:80119682 C/T cg07393940 chr7:158741817 NA 0.36 6.5 0.34 2.84e-10 Life satisfaction; LUSC cis rs2067615 0.579 rs10861655 chr12:107129419 A/G cg15890332 chr12:107067104 RFX4 -0.35 -6.3 -0.33 9.66e-10 Heart rate; LUSC cis rs12681287 0.547 rs6471360 chr8:87513469 C/T cg27223183 chr8:87520930 FAM82B 0.56 7.45 0.38 7.88e-13 Caudate activity during reward; LUSC trans rs10435719 0.867 rs6999030 chr8:11795308 G/A cg14343924 chr8:8086146 FLJ10661 0.45 6.23 0.32 1.39e-9 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg06784218 chr1:46089804 CCDC17 -0.48 -9.23 -0.45 3.17e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2073300 0.609 rs79250740 chr20:23417165 G/A cg12062639 chr20:23401060 NAPB 0.97 8.29 0.41 2.76e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs6445525 1.000 rs4416407 chr3:65995747 T/C cg12639933 chr12:57626296 SHMT2 0.34 6.24 0.32 1.3e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg14773178 chr5:1868261 NA 0.32 5.82 0.3 1.4e-8 Cardiovascular disease risk factors; LUSC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs9420 0.961 rs12804972 chr11:57463767 T/C cg02958346 chr11:57425731 CLP1 -0.44 -6.45 -0.33 4.02e-10 Schizophrenia; LUSC cis rs12760731 0.565 rs11583144 chr1:178222070 C/G cg00404053 chr1:178313656 RASAL2 0.67 6.92 0.35 2.33e-11 Obesity-related traits; LUSC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg11366901 chr6:160182831 ACAT2 0.96 13.17 0.58 3.4e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.16 0.52 8.26e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10266483 0.739 rs2692099 chr7:63767762 G/C cg24201672 chr7:64023550 ZNF680 -0.49 -6.5 -0.34 2.9e-10 Response to statin therapy; LUSC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg08470875 chr2:26401718 FAM59B 0.63 8.21 0.41 4.98e-15 Gut microbiome composition (summer); LUSC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg05340658 chr4:99064831 C4orf37 0.68 11.53 0.53 4.19e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg22920501 chr2:26401640 FAM59B 0.71 9.13 0.45 6.6e-18 Gut microbiome composition (summer); LUSC cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg16230307 chr14:35515116 FAM177A1 0.78 9.88 0.48 2.39e-20 Psoriasis; LUSC trans rs11088226 0.645 rs78172258 chr21:33936539 T/G cg09050820 chr6:167586206 TCP10L2 0.74 9.55 0.46 2.82e-19 Gastritis; LUSC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg06634786 chr22:41940651 POLR3H -0.54 -6.15 -0.32 2.25e-9 Vitiligo; LUSC trans rs59614420 1.000 rs59614420 chr6:161129013 G/A cg00639886 chr12:54943102 PDE1B -0.42 -6.17 -0.32 1.99e-9 Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms; LUSC cis rs6977660 0.714 rs12333747 chr7:19814394 G/A cg05791153 chr7:19748676 TWISTNB 0.7 7.45 0.38 8.29e-13 Thyroid stimulating hormone; LUSC cis rs7106204 0.609 rs16912369 chr11:24297601 C/T ch.11.24196551F chr11:24239977 NA 0.69 5.74 0.3 2.14e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10740039 1.000 rs10994460 chr10:62418791 G/A cg18175470 chr10:62150864 ANK3 -0.44 -6.94 -0.36 2.02e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6714710 0.580 rs11680018 chr2:98479581 C/A cg26665480 chr2:98280029 ACTR1B 0.6 8.81 0.43 6.85e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg11244672 chr19:19639970 YJEFN3 0.61 7.56 0.38 4.04e-13 Bipolar disorder; LUSC cis rs9527 0.590 rs2148200 chr10:104879847 C/A cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.4 -6.07 -0.32 3.51e-9 Alzheimer's disease (late onset); LUSC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg13722127 chr7:150037890 RARRES2 0.4 5.96 0.31 6.24e-9 Blood protein levels;Circulating chemerin levels; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg17178900 chr1:205818956 PM20D1 0.8 13.42 0.59 3.9e-33 Menarche (age at onset); LUSC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11644478 chr21:40555479 PSMG1 0.92 17.54 0.69 2.67e-49 Cognitive function; LUSC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg18180107 chr4:99064573 C4orf37 -0.43 -6.12 -0.32 2.59e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7605827 0.791 rs2042146 chr2:15479372 T/A cg19274914 chr2:15703543 NA 0.44 8.46 0.42 8.7e-16 Educational attainment (years of education); LUSC cis rs35000415 0.938 rs13239597 chr7:128695983 C/A cg19972273 chr7:128594194 NA 0.63 5.72 0.3 2.34e-8 Systemic lupus erythematosus; LUSC trans rs76248362 0.786 rs9580768 chr13:24436910 T/A cg26511321 chr7:27196790 HOXA7 0.54 6.24 0.32 1.35e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg18850127 chr7:39170497 POU6F2 0.65 10.27 0.49 1.1e-21 IgG glycosylation; LUSC cis rs10504229 0.516 rs11781671 chr8:57992733 T/C cg22535103 chr8:58192502 C8orf71 -0.49 -6.43 -0.33 4.5e-10 Developmental language disorder (linguistic errors); LUSC cis rs3858526 0.834 rs10838986 chr11:5977065 A/G cg13902645 chr11:5959945 NA -0.61 -8.48 -0.42 7.35e-16 DNA methylation (variation); LUSC cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg26384229 chr12:38710491 ALG10B 0.89 15.05 0.64 2.03e-39 Bladder cancer; LUSC trans rs3857536 0.813 rs7769683 chr6:66946256 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg05855489 chr10:104503620 C10orf26 0.58 9.29 0.45 2.07e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC trans rs11039798 0.588 rs11039782 chr11:48524785 A/G cg03929089 chr4:120376271 NA 0.61 6.5 0.34 2.97e-10 Axial length; LUSC cis rs17253792 0.822 rs13379343 chr14:56050205 G/A cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.55e-13 Putamen volume; LUSC trans rs6951245 1.000 rs11761941 chr7:1097183 G/A cg13565492 chr6:43139072 SRF -0.63 -6.57 -0.34 1.95e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2832077 0.943 rs4816332 chr21:30201706 T/C cg08807101 chr21:30365312 RNF160 -0.54 -6.85 -0.35 3.48e-11 Cognitive test performance; LUSC cis rs1007190 0.881 rs11079378 chr17:42957462 A/G cg15406952 chr17:42872593 NA 0.55 5.68 0.3 2.97e-8 DNA methylation (variation); LUSC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg02079420 chr8:82753780 SNX16 0.39 6.05 0.31 3.83e-9 Diastolic blood pressure; LUSC cis rs1847202 0.859 rs13096870 chr3:72948172 G/A cg25664220 chr3:72788482 NA -0.42 -7.5 -0.38 5.69e-13 Motion sickness; LUSC cis rs7428 0.502 rs3184781 chr2:85549527 T/C cg24342717 chr2:85555507 TGOLN2 -0.74 -11.93 -0.55 1.44e-27 Ear protrusion; LUSC cis rs977987 0.806 rs4888386 chr16:75389740 A/G cg03315344 chr16:75512273 CHST6 0.54 10.37 0.49 5.04e-22 Dupuytren's disease; LUSC cis rs56399783 0.901 rs73033403 chr7:2877941 G/A cg14895029 chr7:2775587 GNA12 0.52 6.3 0.33 9.29e-10 Childhood ear infection; LUSC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.68 0.47 1.11e-19 Intelligence (multi-trait analysis); LUSC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg03233332 chr7:66118400 NA -0.42 -6.04 -0.31 4.06e-9 Aortic root size; LUSC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg24110177 chr3:50126178 RBM5 -0.56 -9.19 -0.45 4.18e-18 Intelligence (multi-trait analysis); LUSC cis rs10740039 0.516 rs2068042 chr10:62320293 C/T cg18175470 chr10:62150864 ANK3 -0.45 -6.89 -0.35 2.87e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs10782582 0.593 rs11163967 chr1:76154185 T/C cg10523679 chr1:76189770 ACADM -0.49 -7.16 -0.36 5.25e-12 Daytime sleep phenotypes; LUSC cis rs7192380 0.895 rs2917671 chr16:69758741 A/T cg26679644 chr16:69762563 NA -0.34 -5.74 -0.3 2.09e-8 Sjögren's syndrome; LUSC trans rs2147904 1.000 rs2147904 chr1:42371414 C/T cg00436174 chr2:128051630 ERCC3 0.35 6.12 0.32 2.63e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; LUSC cis rs9341808 0.519 rs684251 chr6:80967337 G/A cg08355045 chr6:80787529 NA -0.41 -7.01 -0.36 1.29e-11 Sitting height ratio; LUSC cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.98 -12.92 -0.58 3.12e-31 Chronic sinus infection; LUSC trans rs10435719 0.899 rs9693925 chr8:11789963 A/G cg15556689 chr8:8085844 FLJ10661 0.58 8.71 0.43 1.44e-16 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs2274273 0.870 rs7153645 chr14:55771518 C/G cg04306507 chr14:55594613 LGALS3 0.54 12.08 0.55 3.86e-28 Protein biomarker; LUSC cis rs12681287 0.752 rs13262673 chr8:87293600 G/A cg27223183 chr8:87520930 FAM82B -0.46 -5.86 -0.31 1.13e-8 Caudate activity during reward; LUSC cis rs17270561 0.562 rs12199626 chr6:26013604 G/A cg16482183 chr6:26056742 HIST1H1C 1.07 13.68 0.6 3.98e-34 Iron status biomarkers; LUSC cis rs7707921 0.881 rs12108833 chr5:81371755 A/G cg15871215 chr5:81402204 ATG10 -0.44 -6.53 -0.34 2.41e-10 Breast cancer; LUSC cis rs7267979 0.903 rs2500423 chr20:25374882 G/A cg03522245 chr20:25566470 NINL -0.35 -5.78 -0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg08085267 chr17:45401833 C17orf57 -0.56 -8.55 -0.42 4.51e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs367943 0.712 rs10042223 chr5:112712832 C/T cg12552261 chr5:112820674 MCC 0.37 6.18 0.32 1.88e-9 Type 2 diabetes; LUSC cis rs9399135 0.935 rs11760000 chr6:135370496 G/A cg22676075 chr6:135203613 NA 0.46 7.13 0.36 6.1e-12 Red blood cell count; LUSC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg23172400 chr8:95962367 TP53INP1 -0.4 -8.09 -0.4 1.12e-14 Type 2 diabetes; LUSC cis rs4631830 0.683 rs11004409 chr10:51498019 G/C cg20129853 chr10:51489980 NA 0.36 7.4 0.38 1.14e-12 Prostate-specific antigen levels; LUSC trans rs877282 0.898 rs12356709 chr10:763365 A/G cg13042288 chr15:90349979 ANPEP -0.47 -6.45 -0.33 3.97e-10 Uric acid levels; LUSC cis rs9303401 0.614 rs35057477 chr17:57097064 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 12.87 0.58 4.7e-31 Cognitive test performance; LUSC cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.45 0.38 7.82e-13 Motion sickness; LUSC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg18512352 chr11:47633146 NA -0.47 -9.58 -0.46 2.37e-19 Subjective well-being; LUSC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.58 -0.38 3.42e-13 Aortic root size; LUSC cis rs427941 0.703 rs201451 chr7:101739550 G/A cg06246474 chr7:101738831 CUX1 0.4 6.64 0.34 1.3100000000000001e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg12463550 chr7:65579703 CRCP -0.52 -7.62 -0.38 2.63e-13 Aortic root size; LUSC cis rs478304 0.934 rs498354 chr11:65528213 A/G cg27068330 chr11:65405492 SIPA1 0.64 9.66 0.47 1.28e-19 Acne (severe); LUSC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg05347473 chr6:146136440 FBXO30 0.54 9.34 0.45 1.45e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2439831 0.867 rs2412780 chr15:43655794 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.89 9.51 0.46 4.03e-19 Lung cancer in ever smokers; LUSC cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg08999081 chr20:33150536 PIGU 0.44 8.06 0.4 1.4e-14 Coronary artery disease; LUSC cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg26384229 chr12:38710491 ALG10B 0.85 14.28 0.62 1.95e-36 Bladder cancer; LUSC cis rs477692 0.870 rs532248 chr10:131414156 T/A cg05714579 chr10:131428358 MGMT 0.53 8.05 0.4 1.52e-14 Response to temozolomide; LUSC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg00129232 chr17:37814104 STARD3 -0.46 -6.9 -0.35 2.69e-11 Asthma; LUSC trans rs61931739 0.500 rs9919726 chr12:34510783 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.48 0.59 2.19e-33 Morning vs. evening chronotype; LUSC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg26304593 chr6:42947056 PEX6 -0.54 -8.26 -0.41 3.53e-15 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg14784868 chr12:69753453 YEATS4 0.81 13.62 0.6 6.9e-34 Blood protein levels; LUSC trans rs7647973 0.710 rs6446285 chr3:49626306 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.7 -7.45 -0.38 8.27e-13 Menarche (age at onset); LUSC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs6840360 0.571 rs62329101 chr4:152512239 G/T cg22705602 chr4:152727874 NA -0.32 -6.54 -0.34 2.28e-10 Intelligence (multi-trait analysis); LUSC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg23887609 chr12:130822674 PIWIL1 0.48 6.85 0.35 3.46e-11 Menopause (age at onset); LUSC cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg24812749 chr6:127587940 RNF146 0.92 13.9 0.61 5.47e-35 Breast cancer; LUSC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg09165964 chr15:75287851 SCAMP5 0.52 7.59 0.38 3.32e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs742132 0.597 rs35676593 chr6:25596650 T/G cg03517284 chr6:25882590 NA 0.42 5.72 0.3 2.41e-8 Uric acid levels; LUSC cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg01849466 chr14:104193079 ZFYVE21 -0.58 -8.76 -0.43 1.01e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg16647868 chr5:131706066 SLC22A5 -0.41 -5.83 -0.3 1.28e-8 Breast cancer; LUSC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg04369109 chr6:150039330 LATS1 -0.55 -8.22 -0.41 4.54e-15 Lung cancer; LUSC cis rs8027181 1.000 rs8030477 chr15:73085815 C/T cg25632853 chr15:73088954 NA 0.35 6.96 0.36 1.86e-11 Triglyceride levels; LUSC cis rs11676348 0.846 rs11677534 chr2:219007060 T/C cg06547715 chr2:218990976 CXCR2 0.33 6.59 0.34 1.76e-10 Ulcerative colitis; LUSC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg26850624 chr5:429559 AHRR -0.41 -8.0 -0.4 2.1e-14 Cystic fibrosis severity; LUSC cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.38e-12 Motion sickness; LUSC cis rs12620999 1.000 rs12620999 chr2:238036367 C/T cg23555395 chr2:238036564 NA -0.53 -8.94 -0.44 2.77e-17 Systemic lupus erythematosus; LUSC cis rs1691799 0.867 rs1168338 chr12:66759369 T/C cg16791601 chr12:66731901 HELB -0.71 -12.51 -0.56 1.02e-29 White blood cell count (basophil); LUSC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg23093090 chr10:104574429 C10orf26 0.45 8.43 0.42 1.02e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg17366294 chr4:99064904 C4orf37 0.56 10.05 0.48 5.95e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg04287289 chr16:89883240 FANCA 0.78 13.88 0.6 6.54e-35 Vitiligo; LUSC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg00933542 chr6:150070202 PCMT1 0.33 6.91 0.35 2.39e-11 Lung cancer; LUSC cis rs7224314 1.000 rs7226214 chr17:65383323 C/T cg01507342 chr17:65387096 PITPNC1 -0.44 -7.87 -0.4 4.95e-14 Diisocyanate-induced asthma; LUSC cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg24692254 chr21:30365293 RNF160 0.83 15.26 0.64 3.02e-40 Dental caries; LUSC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg10523679 chr1:76189770 ACADM 0.85 11.28 0.53 3.11e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.91 -0.35 2.51e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.43 -5.92 -0.31 8.14e-9 Renal function-related traits (BUN); LUSC cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg27129171 chr3:47204927 SETD2 0.64 10.78 0.51 1.94e-23 Colorectal cancer; LUSC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.43 -7.23 -0.37 3.39e-12 Prudent dietary pattern; LUSC cis rs72634258 0.554 rs4562654 chr1:7934423 A/T cg00042356 chr1:8021962 PARK7 0.63 7.22 0.37 3.51e-12 Inflammatory bowel disease; LUSC cis rs7759001 0.857 rs4504471 chr6:27372242 C/T cg18711553 chr6:27366782 ZNF391 0.39 5.73 0.3 2.25e-8 Glomerular filtration rate (creatinine); LUSC cis rs11208691 0.513 rs60466849 chr1:66107714 A/G cg14976592 chr1:65886160 LEPROT;LEPR 0.53 6.36 0.33 6.62e-10 Lymphocyte percentage of white cells; LUSC cis rs7106204 0.748 rs4360697 chr11:24217160 A/G ch.11.24196551F chr11:24239977 NA 1.14 14.08 0.61 1.09e-35 Response to Homoharringtonine (cytotoxicity); LUSC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg13939156 chr17:80058883 NA 0.34 6.54 0.34 2.35e-10 Life satisfaction; LUSC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC trans rs11039798 0.841 rs10839174 chr11:48931185 G/A cg15704280 chr7:45808275 SEPT13 0.78 7.55 0.38 4.31e-13 Axial length; LUSC cis rs72949976 0.606 rs11898263 chr2:214030649 A/G cg08319019 chr2:214017104 IKZF2 0.67 11.12 0.52 1.15e-24 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg16479474 chr6:28041457 NA 0.32 5.81 0.3 1.47e-8 Parkinson's disease; LUSC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg00033643 chr7:134001901 SLC35B4 0.42 6.37 0.33 6.41e-10 Mean platelet volume; LUSC cis rs7264396 0.511 rs2425102 chr20:34312303 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.6 -0.43 3.05e-16 Total cholesterol levels; LUSC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg23262073 chr20:60523788 NA -0.42 -6.07 -0.32 3.45e-9 Body mass index; LUSC cis rs34734847 1.000 rs56179458 chr12:121157535 G/A cg27246729 chr12:121163418 ACADS 0.47 7.51 0.38 5.56e-13 Mean corpuscular volume; LUSC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg20933634 chr6:27740509 NA 0.41 5.83 0.3 1.27e-8 Parkinson's disease; LUSC cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg12011299 chr4:100065546 ADH4 -0.7 -10.82 -0.51 1.41e-23 Alcohol dependence; LUSC cis rs950776 0.593 rs621849 chr15:78872861 G/A cg06917634 chr15:78832804 PSMA4 -0.74 -12.79 -0.57 9.19e-31 Sudden cardiac arrest; LUSC cis rs983392 0.642 rs636147 chr11:59957092 C/T cg02771260 chr11:59836817 MS4A3 0.35 5.98 0.31 5.71e-9 Alzheimer's disease (late onset); LUSC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg06671706 chr8:8559999 CLDN23 -0.49 -6.71 -0.34 8.4e-11 Obesity-related traits; LUSC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg12927641 chr6:109611667 NA -0.38 -6.4 -0.33 5.17e-10 Reticulocyte fraction of red cells; LUSC cis rs5758511 0.773 rs7288749 chr22:42356430 C/T cg00645731 chr22:42541494 CYP2D7P1 0.45 7.38 0.37 1.28e-12 Birth weight; LUSC cis rs7927592 0.913 rs3824850 chr11:68341873 A/G cg20283391 chr11:68216788 NA -0.6 -8.38 -0.42 1.53e-15 Total body bone mineral density; LUSC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg15369054 chr17:80825471 TBCD -0.39 -6.46 -0.33 3.74e-10 Breast cancer; LUSC cis rs9323205 0.817 rs56100232 chr14:51699378 A/G cg23942311 chr14:51606299 NA -0.45 -8.85 -0.44 5.29e-17 Cancer; LUSC cis rs2730245 0.636 rs710421 chr7:158668575 T/C cg14689365 chr7:158441557 NCAPG2 0.51 7.32 0.37 1.84e-12 Height; LUSC cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg04727924 chr7:799746 HEATR2 -0.51 -6.23 -0.32 1.42e-9 Cerebrospinal P-tau181p levels; LUSC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs10465746 0.935 rs942848 chr1:84427707 G/C cg10977910 chr1:84465055 TTLL7 0.43 6.29 0.33 1.01e-9 Obesity-related traits; LUSC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg08219700 chr8:58056026 NA 0.53 6.51 0.34 2.7e-10 Developmental language disorder (linguistic errors); LUSC cis rs9300255 0.537 rs1716182 chr12:123686127 A/C cg00376283 chr12:123451042 ABCB9 0.64 8.15 0.41 7.56e-15 Neutrophil percentage of white cells; LUSC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.32 0.56 5.14e-29 Prudent dietary pattern; LUSC cis rs1801251 0.778 rs778340 chr2:233734083 C/T cg08000102 chr2:233561755 GIGYF2 -0.48 -7.68 -0.39 1.74e-13 Coronary artery disease; LUSC cis rs6574644 1.000 rs7156251 chr14:81776179 G/A cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC trans rs11098499 0.954 rs12505469 chr4:120249585 C/T cg25214090 chr10:38739885 LOC399744 0.53 7.8 0.39 7.74e-14 Corneal astigmatism; LUSC cis rs6696846 1.000 rs6696846 chr1:205041952 C/T cg03948781 chr1:205179583 DSTYK 0.31 5.9 0.31 9.16e-9 Red blood cell count; LUSC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.42 0.53 9.8e-26 Prudent dietary pattern; LUSC cis rs2180341 0.618 rs11154398 chr6:127654281 C/A cg27446573 chr6:127587934 RNF146 0.62 9.97 0.48 1.19e-20 Breast cancer; LUSC cis rs17621444 0.522 rs4752372 chr10:121808896 T/C cg02041677 chr10:121771263 NA -0.33 -6.24 -0.32 1.29e-9 IgG glycosylation; LUSC cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.87 0.51 8.86e-24 Morning vs. evening chronotype; LUSC cis rs61990749 0.597 rs1549119 chr14:78219812 A/T cg02301378 chr14:78227641 SNW1;C14orf178 0.6 6.57 0.34 1.94e-10 Fibroblast growth factor basic levels; LUSC cis rs1003719 0.688 rs2835660 chr21:38568882 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.66 -10.21 -0.49 1.83e-21 Eye color traits; LUSC cis rs1577917 0.771 rs9353318 chr6:86231721 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.54 0.42 4.94e-16 Response to antipsychotic treatment; LUSC cis rs7215564 0.908 rs35821645 chr17:78652479 G/A cg23238734 chr17:78661607 RPTOR 0.49 6.28 0.32 1.08e-9 Myopia (pathological); LUSC cis rs28830936 0.966 rs8025714 chr15:42120157 G/C cg17847044 chr15:42102381 MAPKBP1 -0.27 -5.92 -0.31 7.95e-9 Diastolic blood pressure; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg12419862 chr22:24373484 LOC391322 -0.84 -13.65 -0.6 5.34e-34 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs897080 0.515 rs1067400 chr2:44677647 G/A cg00619915 chr2:44497795 NA -0.43 -6.07 -0.32 3.48e-9 Height; LUSC cis rs3087591 0.919 rs2285892 chr17:29553485 G/A cg24425628 chr17:29625626 OMG;NF1 -0.57 -8.33 -0.41 2.15e-15 Hip circumference; LUSC cis rs5758511 0.680 rs58654759 chr22:42642576 T/C cg12850546 chr22:42539477 CYP2D7P1 -0.48 -5.89 -0.31 9.19e-9 Birth weight; LUSC cis rs2839186 0.786 rs7409792 chr21:47691729 C/A cg11766577 chr21:47581405 C21orf56 -0.47 -7.11 -0.36 7.3e-12 Testicular germ cell tumor; LUSC cis rs7592578 0.766 rs62181052 chr2:191387858 A/G cg10560079 chr2:191398806 TMEM194B -0.71 -8.0 -0.4 2.07e-14 Diastolic blood pressure; LUSC cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg13010199 chr12:38710504 ALG10B 0.68 10.84 0.51 1.21e-23 Heart rate; LUSC trans rs62238980 0.614 rs76853252 chr22:32455857 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg22870994 chr11:71340352 NA -0.41 -6.58 -0.34 1.8e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg18904891 chr8:8559673 CLDN23 0.58 8.07 0.4 1.31e-14 Obesity-related traits; LUSC cis rs4595586 0.655 rs7958206 chr12:39329294 G/A cg26384229 chr12:38710491 ALG10B 0.46 6.4 0.33 5.41e-10 Morning vs. evening chronotype; LUSC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg06238570 chr21:40685208 BRWD1 0.47 7.24 0.37 3.13e-12 Cognitive function; LUSC trans rs6502050 0.835 rs9911379 chr17:80114529 A/G cg07393940 chr7:158741817 NA 0.37 6.62 0.34 1.43e-10 Life satisfaction; LUSC cis rs1107366 0.722 rs10934753 chr3:125906179 G/A cg08481491 chr3:125900108 ALDH1L1 -0.28 -5.69 -0.3 2.85e-8 Metabolite levels; LUSC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg01842473 chr11:617407 IRF7;MUPCDH -0.6 -8.18 -0.41 6.14e-15 Systemic lupus erythematosus; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg26787244 chr11:644011 NA -0.41 -6.11 -0.32 2.72e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs8060686 0.841 rs73594554 chr16:67920049 G/A cg27539214 chr16:67997921 SLC12A4 -0.46 -5.94 -0.31 7.15e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs12681287 0.752 rs6985427 chr8:87302745 C/T cg27223183 chr8:87520930 FAM82B -0.46 -5.74 -0.3 2.18e-8 Caudate activity during reward; LUSC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg05347473 chr6:146136440 FBXO30 -0.58 -10.0 -0.48 9.08e-21 Lobe attachment (rater-scored or self-reported); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg24429831 chr19:36120171 RBM42 0.38 6.2 0.32 1.71e-9 Triglycerides; LUSC cis rs4604732 0.631 rs1106719 chr1:247624713 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 -0.44 -6.25 -0.32 1.22e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs2806561 0.704 rs636940 chr1:23522967 A/T cg19743168 chr1:23544995 NA 0.46 9.11 0.45 8.03e-18 Height; LUSC cis rs6582630 0.555 rs35186318 chr12:38295822 C/T cg13010199 chr12:38710504 ALG10B -0.46 -6.81 -0.35 4.46e-11 Drug-induced liver injury (flucloxacillin); LUSC cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg23260525 chr10:116636907 FAM160B1 0.47 10.19 0.49 2.13e-21 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.43 0.33 4.44e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs1832871 0.505 rs11757895 chr6:158812456 G/T cg07165851 chr6:158734300 TULP4 0.44 6.28 0.32 1.08e-9 Height; LUSC cis rs3743266 0.634 rs7165874 chr15:60784609 A/T cg21667061 chr15:60772094 NARG2 0.38 6.32 0.33 8.55e-10 Menarche (age at onset); LUSC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.45 -7.12 -0.36 6.52e-12 Alzheimer's disease (late onset); LUSC cis rs1030268 0.608 rs12707106 chr7:133311350 A/T cg10665199 chr7:133106180 EXOC4 0.6 6.86 0.35 3.34e-11 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg02308097 chr17:79868996 PCYT2 -0.4 -5.97 -0.31 5.9e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg27279351 chr12:120934652 DYNLL1 0.63 8.37 0.42 1.61e-15 High light scatter reticulocyte count; LUSC cis rs874628 0.686 rs885683 chr19:18244690 A/G cg00493341 chr19:18228948 MAST3 -0.43 -5.94 -0.31 7.11e-9 Multiple sclerosis; LUSC cis rs3768617 0.782 rs12143211 chr1:182990172 C/G ch.1.3577855R chr1:183094577 LAMC1 0.58 8.39 0.42 1.42e-15 Fuchs's corneal dystrophy; LUSC cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg24375607 chr4:120327624 NA 0.78 11.4 0.53 1.21e-25 Corneal astigmatism; LUSC cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.83 -0.39 6.66e-14 Chronic sinus infection; LUSC cis rs714027 0.511 rs131274 chr22:30153864 G/A cg11564601 chr22:30592435 NA 0.32 5.8 0.3 1.58e-8 Lymphocyte counts; LUSC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg04369109 chr6:150039330 LATS1 -0.59 -8.69 -0.43 1.64e-16 Lung cancer; LUSC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -7.34 -0.37 1.68e-12 Cystic fibrosis severity; LUSC cis rs6076065 0.509 rs2000261 chr20:23311090 G/T cg11657817 chr20:23433608 CST11 0.39 7.28 0.37 2.4e-12 Facial morphology (factor 15, philtrum width); LUSC trans rs561341 1.000 rs2344312 chr17:30243583 G/T cg20587970 chr11:113659929 NA -1.06 -14.45 -0.62 4.35e-37 Hip circumference adjusted for BMI; LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg06873352 chr17:61820015 STRADA 0.72 12.86 0.58 5.17e-31 Prudent dietary pattern; LUSC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg03060546 chr3:49711283 APEH -0.68 -7.76 -0.39 1.07e-13 Menarche (age at onset); LUSC trans rs12509991 0.847 rs7661885 chr4:126958758 A/G cg10515953 chr10:61666281 CCDC6 0.46 6.13 0.32 2.46e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs35306767 0.714 rs12762955 chr10:1078782 A/C cg20503657 chr10:835505 NA 0.56 7.31 0.37 2.04e-12 Eosinophil percentage of granulocytes; LUSC cis rs4843747 0.671 rs9921236 chr16:88117015 G/T cg17633681 chr16:88106987 BANP 0.5 9.75 0.47 6.26e-20 Menopause (age at onset); LUSC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg10053473 chr17:62856997 LRRC37A3 -0.67 -10.48 -0.5 2.07e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9393692 0.676 rs1543681 chr6:26187783 G/T cg13736514 chr6:26305472 NA -0.38 -7.31 -0.37 1.99e-12 Educational attainment; LUSC cis rs7107174 1.000 rs2511175 chr11:77975081 A/G cg02023728 chr11:77925099 USP35 0.42 6.01 0.31 4.98e-9 Testicular germ cell tumor; LUSC cis rs7264396 0.635 rs6058346 chr20:34481043 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.9 -0.44 3.59e-17 Total cholesterol levels; LUSC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg18827107 chr12:86230957 RASSF9 0.47 7.04 0.36 1.09e-11 Major depressive disorder; LUSC cis rs2294693 0.945 rs9369260 chr6:41010368 C/G cg14769373 chr6:40998127 UNC5CL 0.5 6.75 0.35 6.42e-11 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs7202877 0.561 rs7202083 chr16:75383727 G/T cg03315344 chr16:75512273 CHST6 0.45 5.8 0.3 1.51e-8 Type 2 diabetes;Type 1 diabetes; LUSC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg11764359 chr7:65958608 NA -0.68 -10.93 -0.51 5.47e-24 Aortic root size; LUSC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg07701084 chr6:150067640 NUP43 0.57 8.86 0.44 4.87e-17 Lung cancer; LUSC cis rs11051970 0.569 rs7298319 chr12:32530385 C/G cg02745156 chr12:32552066 NA -0.4 -6.87 -0.35 3.18e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg26566898 chr11:117069891 TAGLN 0.37 7.22 0.37 3.49e-12 Blood protein levels; LUSC cis rs713587 1.000 rs713587 chr2:25158281 C/T cg15423357 chr2:25149977 NA 0.44 9.05 0.44 1.19e-17 Body mass index in non-asthmatics; LUSC cis rs10992471 0.603 rs747628 chr9:95289532 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.9 -0.35 2.68e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg01879757 chr17:41196368 BRCA1 -0.46 -7.1 -0.36 7.39e-12 Menopause (age at onset); LUSC cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg13010199 chr12:38710504 ALG10B 0.7 10.92 0.51 5.95e-24 Bladder cancer; LUSC cis rs367943 1.000 rs460079 chr5:112800525 G/A cg12552261 chr5:112820674 MCC -0.45 -7.2 -0.37 4.07e-12 Type 2 diabetes; LUSC cis rs614226 1.000 rs614226 chr12:120974510 C/T cg21053147 chr12:120880522 NA 0.5 6.12 0.32 2.63e-9 Type 1 diabetes nephropathy; LUSC cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg06462663 chr19:18546047 ISYNA1 0.47 7.93 0.4 3.33e-14 Breast cancer; LUSC cis rs3770081 1.000 rs58381542 chr2:86203685 G/T cg23655155 chr2:86332777 POLR1A;PTCD3 -1.0 -6.54 -0.34 2.36e-10 Facial emotion recognition (sad faces); LUSC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg13939156 chr17:80058883 NA 0.35 7.07 0.36 8.95e-12 Life satisfaction; LUSC trans rs1941687 0.797 rs8098255 chr18:31401850 A/G cg27147174 chr7:100797783 AP1S1 0.42 6.33 0.33 7.94e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg05347473 chr6:146136440 FBXO30 0.48 8.08 0.4 1.16e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs500891 0.574 rs12524383 chr6:84136605 T/C cg08257003 chr6:84140564 ME1 0.37 9.1 0.45 8.48e-18 Platelet-derived growth factor BB levels; LUSC cis rs1003719 0.788 rs1543748 chr21:38446581 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.28 0.53 3.1e-25 Eye color traits; LUSC trans rs8073060 0.586 rs3859284 chr17:34012792 C/T cg19694781 chr19:47549865 TMEM160 -1.13 -17.91 -0.7 9.52e-51 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs1215050 0.740 rs9994227 chr4:98767094 T/G cg05340658 chr4:99064831 C4orf37 0.44 6.96 0.36 1.77e-11 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7824557 0.564 rs13260727 chr8:11232860 A/G cg06636001 chr8:8085503 FLJ10661 0.5 7.51 0.38 5.43e-13 Retinal vascular caliber; LUSC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg04267008 chr7:1944627 MAD1L1 -0.6 -9.14 -0.45 6.04e-18 Bipolar disorder and schizophrenia; LUSC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg08645402 chr16:4508243 NA 0.48 7.5 0.38 5.74e-13 Schizophrenia; LUSC cis rs9640161 0.659 rs59572505 chr7:150014986 C/T cg21361702 chr7:150065534 REPIN1 0.45 6.21 0.32 1.56e-9 Blood protein levels;Circulating chemerin levels; LUSC trans rs2243480 1.000 rs6970243 chr7:65388490 C/A cg10756647 chr7:56101905 PSPH 0.87 8.55 0.42 4.6e-16 Diabetic kidney disease; LUSC trans rs4718428 0.705 rs10267335 chr7:66403220 G/T cg18876405 chr7:65276391 NA 0.49 6.68 0.34 9.84e-11 Corneal structure; LUSC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.75 0.35 6.47e-11 Tonsillectomy; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23945789 chr12:111180856 PPP1CC -0.41 -5.96 -0.31 6.45e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs968451 0.865 rs2076125 chr22:39711351 A/G cg17798944 chr22:39715225 SNORD43;RPL3 0.71 9.33 0.45 1.47e-18 Primary biliary cholangitis; LUSC cis rs735396 0.770 rs1169300 chr12:121431225 G/A cg25281562 chr12:121454272 C12orf43 0.45 5.68 0.3 2.86e-8 N-glycan levels; LUSC cis rs477692 0.789 rs506915 chr10:131398005 A/G cg05714579 chr10:131428358 MGMT 0.47 6.86 0.35 3.45e-11 Response to temozolomide; LUSC cis rs9527 0.590 rs11191572 chr10:104893137 A/G cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs41271473 0.607 rs6692032 chr1:228853984 G/C cg16512390 chr1:228756714 NA 0.49 6.98 0.36 1.55e-11 Chronic lymphocytic leukemia; LUSC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg18404041 chr3:52824283 ITIH1 -0.58 -11.31 -0.53 2.52e-25 Bipolar disorder; LUSC cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg15691649 chr6:25882328 NA -0.35 -5.92 -0.31 8.08e-9 Blood metabolite levels; LUSC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg06484146 chr7:12443880 VWDE -0.68 -7.08 -0.36 8.67e-12 Coronary artery disease; LUSC cis rs2742417 1.000 rs2742369 chr3:45754487 C/A cg09608765 chr3:45636137 LIMD1 -0.38 -7.53 -0.38 4.87e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.82 0.43 6.27e-17 Motion sickness; LUSC trans rs10435719 0.764 rs10103485 chr8:11787563 C/T cg08975724 chr8:8085496 FLJ10661 0.5 7.31 0.37 1.95e-12 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg03517284 chr6:25882590 NA -0.4 -7.26 -0.37 2.72e-12 Height; LUSC cis rs10911251 0.508 rs2245784 chr1:183107665 G/A ch.1.3577855R chr1:183094577 LAMC1 0.69 10.61 0.5 7.28e-23 Colorectal cancer; LUSC cis rs1448094 0.967 rs7978132 chr12:86323484 T/C cg02569458 chr12:86230093 RASSF9 0.42 6.71 0.34 8.49e-11 Major depressive disorder; LUSC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg25039879 chr17:56429692 SUPT4H1 0.68 9.0 0.44 1.72e-17 Cognitive test performance; LUSC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg09365446 chr1:150670422 GOLPH3L 0.55 8.38 0.42 1.45e-15 Tonsillectomy; LUSC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg09021430 chr5:549028 NA -0.55 -7.17 -0.37 4.85e-12 Lung disease severity in cystic fibrosis; LUSC cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg05347473 chr6:146136440 FBXO30 0.46 7.99 0.4 2.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg01256987 chr12:42539512 GXYLT1 -0.45 -8.68 -0.43 1.82e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg26395211 chr5:140044315 WDR55 -0.39 -5.95 -0.31 6.92e-9 Depressive symptoms (multi-trait analysis); LUSC trans rs12524093 0.541 rs74961892 chr6:143041640 A/T cg22454011 chr18:13611439 C18orf1 0.68 5.96 0.31 6.53e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.821 rs3181073 chr20:30307199 A/C cg13852791 chr20:30311386 BCL2L1 -0.82 -11.05 -0.52 2.16e-24 Mean corpuscular hemoglobin; LUSC cis rs17270561 0.609 rs9379786 chr6:25730255 T/C cg16482183 chr6:26056742 HIST1H1C 0.64 9.03 0.44 1.44e-17 Iron status biomarkers; LUSC cis rs1568889 1.000 rs61889027 chr11:28281908 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 8.82 0.43 6.31e-17 Bipolar disorder; LUSC cis rs597539 0.616 rs10896386 chr11:68722694 C/T cg18350739 chr11:68623251 NA -0.37 -6.31 -0.33 8.85e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs709400 1.000 rs6593 chr14:104163282 G/A cg24130564 chr14:104152367 KLC1 -0.54 -7.78 -0.39 9.15e-14 Body mass index; LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg09877947 chr5:131593287 PDLIM4 -0.45 -6.94 -0.36 2.02e-11 Breast cancer; LUSC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg04414720 chr1:150670196 GOLPH3L 0.57 9.22 0.45 3.31e-18 Tonsillectomy; LUSC cis rs977987 0.778 rs2113232 chr16:75391185 T/C cg03315344 chr16:75512273 CHST6 0.5 9.57 0.46 2.41e-19 Dupuytren's disease; LUSC cis rs765787 0.530 rs2668737 chr15:45522799 C/T cg25801113 chr15:45476975 SHF 0.35 7.37 0.37 1.39e-12 Uric acid levels; LUSC cis rs2708977 0.609 rs611943 chr2:97067074 T/C cg01950434 chr2:97203154 ARID5A -0.47 -6.36 -0.33 6.61e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.49 6.69 0.34 9.66e-11 Tonsillectomy; LUSC cis rs977987 0.806 rs4888383 chr16:75386349 C/T cg03315344 chr16:75512273 CHST6 0.51 9.67 0.47 1.19e-19 Dupuytren's disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20784733 chr7:66205729 RABGEF1 -0.45 -6.07 -0.32 3.43e-9 Bipolar disorder and schizophrenia; LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg02574844 chr11:5959923 NA -0.41 -6.04 -0.31 4e-9 DNA methylation (variation); LUSC cis rs9486719 0.948 rs2472904 chr6:96874962 T/G cg06623918 chr6:96969491 KIAA0776 0.8 9.89 0.48 2.15e-20 Migraine;Coronary artery disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15069758 chr1:110198731 GSTM4 0.4 5.97 0.31 6e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg00684032 chr4:1343700 KIAA1530 0.32 5.67 0.3 3.14e-8 Longevity; LUSC cis rs9650657 0.746 rs4841441 chr8:10630898 C/A cg27411982 chr8:10470053 RP1L1 -0.4 -6.51 -0.34 2.79e-10 Neuroticism; LUSC cis rs10489202 0.632 rs3767476 chr1:168066940 C/T cg24449463 chr1:168025552 DCAF6 -0.73 -11.46 -0.53 7.09e-26 Schizophrenia; LUSC trans rs11039798 0.588 rs10160381 chr11:48599491 A/G cg03929089 chr4:120376271 NA 0.59 6.58 0.34 1.79e-10 Axial length; LUSC cis rs10875746 0.903 rs2158516 chr12:48490834 T/A cg13454099 chr12:49076203 C12orf41 -0.5 -5.75 -0.3 2.02e-8 Longevity (90 years and older); LUSC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.75 0.35 6.62e-11 Platelet count; LUSC cis rs11662586 1.000 rs12605316 chr18:77693600 C/T cg20368463 chr18:77673604 PQLC1 0.61 8.23 0.41 4.32e-15 Exploratory eye movement dysfunction in schizophrenia (responsive search score); LUSC trans rs11098499 0.697 rs11941899 chr4:120382758 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.16 0.32 2.14e-9 Corneal astigmatism; LUSC cis rs7224314 1.000 rs62084076 chr17:65383102 G/A cg01507342 chr17:65387096 PITPNC1 -0.45 -8.03 -0.4 1.67e-14 Diisocyanate-induced asthma; LUSC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg27411982 chr8:10470053 RP1L1 0.4 6.39 0.33 5.62e-10 Neuroticism; LUSC cis rs9309473 0.950 rs11689588 chr2:73773691 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.98 -0.36 1.57e-11 Metabolite levels; LUSC cis rs62400317 0.762 rs12214794 chr6:44931465 G/A cg20913747 chr6:44695427 NA -0.46 -7.27 -0.37 2.59e-12 Total body bone mineral density; LUSC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg00012203 chr2:219082015 ARPC2 -0.7 -11.59 -0.54 2.53e-26 Colorectal cancer; LUSC cis rs2282300 0.739 rs35229181 chr11:30241698 A/G cg06241208 chr11:30344200 C11orf46 -0.44 -5.65 -0.3 3.52e-8 Morning vs. evening chronotype; LUSC cis rs4959270 0.874 rs4311550 chr6:451925 A/G cg09757644 chr6:447497 NA -0.28 -5.89 -0.31 9.21e-9 Limited cutaneous systemic scleroderma; LUSC cis rs7428 0.545 rs7572750 chr2:85552186 C/A cg24342717 chr2:85555507 TGOLN2 -0.74 -12.28 -0.56 7.19e-29 Ear protrusion; LUSC cis rs9467773 0.620 rs2451732 chr6:26622904 A/T cg11502198 chr6:26597334 ABT1 -0.69 -11.59 -0.54 2.42e-26 Intelligence (multi-trait analysis); LUSC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg17971929 chr21:40555470 PSMG1 0.49 7.16 0.36 5.31e-12 Menarche (age at onset); LUSC cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg22676075 chr6:135203613 NA 0.58 9.3 0.45 1.96e-18 High light scatter reticulocyte percentage of red cells; LUSC cis rs1595825 1.000 rs59441945 chr2:198879645 T/A cg00982548 chr2:198649783 BOLL -0.5 -6.23 -0.32 1.44e-9 Ulcerative colitis; LUSC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg07507251 chr3:52567010 NT5DC2 0.33 6.54 0.34 2.28e-10 Bipolar disorder; LUSC cis rs932287 1.000 rs932287 chr11:9044767 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -7.35 -0.37 1.56e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg02931644 chr1:25747376 RHCE 0.32 5.82 0.3 1.41e-8 Erythrocyte sedimentation rate; LUSC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11644478 chr21:40555479 PSMG1 0.92 17.57 0.69 2.04e-49 Cognitive function; LUSC cis rs7904368 0.806 rs6602161 chr10:16862280 A/G cg23933602 chr10:16859644 RSU1 0.51 6.21 0.32 1.6e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs1048238 0.506 rs7552077 chr1:16196759 A/G cg21385522 chr1:16154831 NA 0.54 8.66 0.43 2.02e-16 Systolic blood pressure; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg00634984 chr7:65235879 NA -0.4 -5.83 -0.3 1.32e-8 Calcium levels; LUSC cis rs7107174 1.000 rs7113042 chr11:78035832 C/T cg02023728 chr11:77925099 USP35 -0.43 -6.39 -0.33 5.62e-10 Testicular germ cell tumor; LUSC trans rs61931739 0.500 rs7489130 chr12:34539674 C/A cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs10464366 0.746 rs11760807 chr7:39142377 G/A cg15212455 chr7:39170539 POU6F2 0.59 9.46 0.46 5.8e-19 IgG glycosylation; LUSC cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg08999081 chr20:33150536 PIGU 0.52 10.31 0.49 8.06e-22 Glomerular filtration rate (creatinine); LUSC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg22875332 chr1:76189707 ACADM 0.85 15.63 0.65 1.01e-41 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1008375 0.900 rs13101742 chr4:17701297 G/A cg18681998 chr4:17616180 MED28 -0.79 -12.75 -0.57 1.28e-30 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1003719 0.788 rs4816560 chr21:38487561 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.36 0.53 1.64e-25 Eye color traits; LUSC cis rs10782582 0.569 rs1770892 chr1:76389359 T/C cg10523679 chr1:76189770 ACADM -0.47 -6.77 -0.35 5.77e-11 Daytime sleep phenotypes; LUSC cis rs6696846 0.765 rs3738155 chr1:205074424 C/T cg03948781 chr1:205179583 DSTYK 0.33 6.46 0.33 3.66e-10 Red blood cell count; LUSC cis rs11048434 0.761 rs12828902 chr12:9132231 C/T cg13575925 chr12:9217583 LOC144571 0.34 6.47 0.33 3.55e-10 Sjögren's syndrome; LUSC cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs694739 0.894 rs887314 chr11:64053157 T/G cg23796481 chr11:64053134 BAD;GPR137 0.61 9.55 0.46 2.96e-19 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC trans rs61931739 0.824 rs406753 chr12:34117408 A/G cg24313572 chr1:56050060 NA -0.29 -5.96 -0.31 6.34e-9 Morning vs. evening chronotype; LUSC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.35 -5.66 -0.3 3.18e-8 Total body bone mineral density; LUSC cis rs12190007 0.547 rs3006182 chr6:169808323 C/T cg15038512 chr6:170123185 PHF10 -0.38 -6.14 -0.32 2.34e-9 Obesity-related traits; LUSC cis rs6845621 0.727 rs2215763 chr4:18910559 G/A cg12196642 chr4:18937545 NA -0.33 -6.22 -0.32 1.45e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg16228356 chr17:43848958 NA 0.27 6.18 0.32 1.88e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg07926092 chr13:79233506 RNF219 0.49 5.84 0.3 1.24e-8 Large artery stroke; LUSC cis rs4888262 0.545 rs8050624 chr16:74686690 A/G cg01733217 chr16:74700730 RFWD3 -0.81 -13.55 -0.6 1.24e-33 Testicular germ cell tumor; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg24486960 chr6:44225443 SLC35B2 0.8 6.64 0.34 1.25e-10 Cognitive performance; LUSC cis rs6693567 0.565 rs696617 chr1:150376311 G/T cg15654264 chr1:150340011 RPRD2 0.45 7.18 0.37 4.49e-12 Migraine; LUSC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg15691649 chr6:25882328 NA 0.36 5.98 0.31 5.82e-9 Blood metabolite levels; LUSC cis rs1153858 1.000 rs28679834 chr15:45616206 C/T cg14582100 chr15:45693742 SPATA5L1 0.58 10.46 0.5 2.44e-22 Homoarginine levels; LUSC cis rs6582630 0.634 rs10748443 chr12:38734062 G/T cg26384229 chr12:38710491 ALG10B 0.6 9.48 0.46 4.93e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.12 0.36 6.82e-12 Parkinson's disease; LUSC cis rs4555082 0.957 rs2735818 chr14:105714751 A/G cg06808227 chr14:105710500 BRF1 -0.72 -11.65 -0.54 1.49e-26 Mean platelet volume;Platelet distribution width; LUSC cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg15744005 chr10:104629667 AS3MT -0.33 -6.79 -0.35 5.08e-11 Arsenic metabolism; LUSC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg18305652 chr10:134549665 INPP5A 0.45 6.71 0.34 8.4e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs950027 0.620 rs1153857 chr15:45659095 G/T cg04036182 chr15:45458818 NA 0.35 5.75 0.3 2.01e-8 Response to fenofibrate (adiponectin levels); LUSC trans rs7824557 0.510 rs4841524 chr8:11243126 C/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.13 -0.41 8.57e-15 Retinal vascular caliber; LUSC cis rs11168618 0.686 rs11168574 chr12:48838969 T/A cg24011408 chr12:48396354 COL2A1 0.38 6.07 0.32 3.48e-9 Adiponectin levels; LUSC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg13770153 chr20:60521292 NA -0.62 -8.2 -0.41 5.29e-15 Body mass index; LUSC cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg08109568 chr15:31115862 NA -0.58 -8.01 -0.4 1.96e-14 Huntington's disease progression; LUSC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg22437258 chr11:111473054 SIK2 -0.46 -6.31 -0.33 8.62e-10 Primary sclerosing cholangitis; LUSC cis rs34172651 0.917 rs200533 chr16:24754771 C/T cg00339695 chr16:24857497 SLC5A11 -0.36 -6.41 -0.33 4.94e-10 Intelligence (multi-trait analysis); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg04597389 chr17:79935740 ASPSCR1 -0.45 -6.86 -0.35 3.37e-11 Electrocardiographic conduction measures; LUSC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg10802521 chr3:52805072 NEK4 0.5 7.96 0.4 2.65e-14 Bipolar disorder; LUSC cis rs2625529 0.503 rs7162299 chr15:72414065 A/G cg16672083 chr15:72433130 SENP8 0.49 8.05 0.4 1.46e-14 Red blood cell count; LUSC cis rs7208859 0.623 rs3752020 chr17:29111125 T/G cg13385521 chr17:29058706 SUZ12P 0.68 6.7 0.34 8.9e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7954584 0.567 rs11043243 chr12:122356370 G/C cg13699009 chr12:122356056 WDR66 0.49 7.47 0.38 6.89e-13 Mean corpuscular volume; LUSC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg06618935 chr21:46677482 NA -0.41 -8.15 -0.41 7.54e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4654899 1.000 rs7550267 chr1:21448792 T/C cg01072550 chr1:21505969 NA -0.53 -8.27 -0.41 3.13e-15 Superior frontal gyrus grey matter volume; LUSC cis rs1983170 0.736 rs4484968 chr1:92012005 C/A cg25838465 chr1:92012736 NA 0.46 5.73 0.3 2.2e-8 Eosinophil percentage of white cells; LUSC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg26162295 chr17:38119207 GSDMA 0.24 5.71 0.3 2.56e-8 Self-reported allergy; LUSC cis rs854765 0.534 rs7207461 chr17:17949789 T/G cg09796270 chr17:17721594 SREBF1 -0.4 -6.98 -0.36 1.56e-11 Total body bone mineral density; LUSC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg13393036 chr8:95962371 TP53INP1 -0.46 -10.25 -0.49 1.3e-21 Type 2 diabetes; LUSC trans rs853679 0.599 rs156743 chr6:27967089 T/C cg01620082 chr3:125678407 NA -0.63 -6.89 -0.35 2.83e-11 Depression; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24508409 chr1:112298175 DDX20;C1orf183 -0.4 -6.17 -0.32 1.92e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1371867 0.875 rs1788169 chr8:101326314 C/T cg06002616 chr8:101225028 SPAG1 -0.46 -7.49 -0.38 6.19e-13 Atrioventricular conduction; LUSC cis rs8044995 0.706 rs111948678 chr16:68255959 G/A cg05110241 chr16:68378359 PRMT7 -0.64 -6.99 -0.36 1.46e-11 Schizophrenia; LUSC cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg25817165 chr18:72167213 CNDP2 -0.75 -11.28 -0.53 3.32e-25 Refractive error; LUSC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg07211511 chr3:129823064 LOC729375 -1.24 -20.31 -0.74 2.85e-60 Blood pressure (smoking interaction); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg21219744 chr4:44680344 GUF1 0.47 6.74 0.35 7.13e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7258465 1.000 rs34746918 chr19:18539744 C/T cg11102782 chr19:18549136 ISYNA1 -0.32 -6.03 -0.31 4.46e-9 Breast cancer; LUSC trans rs629535 0.551 rs62513429 chr8:70149995 A/C cg21567404 chr3:27674614 NA -0.93 -13.37 -0.59 5.88e-33 Dupuytren's disease; LUSC cis rs4845459 0.967 rs6700158 chr1:152592828 T/G cg08895932 chr1:152778580 LCE1C -0.38 -6.4 -0.33 5.23e-10 Psoriasis; LUSC cis rs453301 0.658 rs13271797 chr8:8885954 G/A cg15556689 chr8:8085844 FLJ10661 -0.62 -9.94 -0.48 1.46e-20 Joint mobility (Beighton score); LUSC cis rs34734847 0.750 rs3915 chr12:121176679 C/T cg21892295 chr12:121157589 UNC119B -0.33 -5.72 -0.3 2.33e-8 Mean corpuscular volume; LUSC cis rs72781680 1.000 rs72781654 chr2:24218099 T/C cg08917208 chr2:24149416 ATAD2B 0.59 6.76 0.35 6.03e-11 Lymphocyte counts; LUSC cis rs1034435 0.547 rs6008741 chr22:48897881 G/A cg05992904 chr22:48892994 FAM19A5 -0.39 -6.84 -0.35 3.87e-11 Late-onset Alzheimer's disease; LUSC cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg05890377 chr2:74357713 NA 0.72 13.73 0.6 2.5e-34 Gestational age at birth (maternal effect); LUSC cis rs12220238 0.908 rs10824086 chr10:75912668 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 6.92 0.35 2.36e-11 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs7241530 0.636 rs8099795 chr18:75909874 T/G cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC trans rs7613875 0.578 rs2526749 chr3:50076734 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.83 -0.39 6.55e-14 Body mass index; LUSC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg26513180 chr16:89883248 FANCA 0.9 17.58 0.69 1.92e-49 Vitiligo; LUSC cis rs1957429 0.901 rs2884308 chr14:65350406 A/T cg23373153 chr14:65346875 NA -1.02 -12.58 -0.57 5.57e-30 Pediatric areal bone mineral density (radius); LUSC trans rs561341 0.941 rs4625780 chr17:30249214 A/C cg20587970 chr11:113659929 NA -1.04 -12.8 -0.57 8.19e-31 Hip circumference adjusted for BMI; LUSC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg09365446 chr1:150670422 GOLPH3L 0.52 7.52 0.38 5.19e-13 Melanoma; LUSC cis rs6938 0.563 rs12917376 chr15:75116167 C/T cg09165964 chr15:75287851 SCAMP5 0.5 7.43 0.38 9.24e-13 Breast cancer; LUSC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg12751644 chr20:60527061 NA -0.34 -6.16 -0.32 2.07e-9 Body mass index; LUSC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg21573476 chr21:45109991 RRP1B -0.37 -6.0 -0.31 5.14e-9 Mean corpuscular volume; LUSC trans rs6598955 0.671 rs12088858 chr1:26643708 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.65 -8.31 -0.41 2.44e-15 Obesity-related traits; LUSC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg14668632 chr7:2872130 GNA12 0.47 7.17 0.37 4.83e-12 Height; LUSC cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg09526685 chr4:187126073 CYP4V2 0.62 6.74 0.35 7.18e-11 Blood protein levels; LUSC cis rs2348418 0.831 rs7299042 chr12:28724683 G/T cg13890972 chr12:28721907 NA -0.36 -6.2 -0.32 1.69e-9 Lung function (FVC);Lung function (FEV1); LUSC cis rs62432291 0.681 rs417719 chr6:159658042 C/T cg14500486 chr6:159655392 FNDC1 -0.52 -5.7 -0.3 2.67e-8 Joint mobility (Beighton score); LUSC cis rs36093844 0.800 rs17817326 chr11:85595213 C/T cg16165120 chr11:85566439 CCDC83 -0.39 -5.65 -0.3 3.42e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); LUSC cis rs10504229 0.679 rs2218271 chr8:58052446 T/A cg22535103 chr8:58192502 C8orf71 -0.57 -6.69 -0.34 9.59e-11 Developmental language disorder (linguistic errors); LUSC cis rs834603 0.546 rs1534138 chr7:47482750 T/C cg09696706 chr7:47479511 TNS3 0.35 6.42 0.33 4.81e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC trans rs9341835 0.518 rs2622293 chr6:64218491 T/C cg19533977 chr17:57719682 CLTC 0.33 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg11494091 chr17:61959527 GH2 0.4 6.91 0.35 2.47e-11 Height; LUSC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.22 0.52 5.09e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.14 16.34 0.67 1.63e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11971779 0.648 rs7799165 chr7:139084957 G/T cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg14993813 chr1:46806288 NSUN4 -0.52 -7.24 -0.37 3.02e-12 Menopause (age at onset); LUSC cis rs1538970 1.000 rs9326141 chr1:45828943 A/G cg05343316 chr1:45956843 TESK2 -0.61 -8.75 -0.43 1.06e-16 Platelet count; LUSC cis rs870825 0.616 rs7668009 chr4:185641998 A/C cg04058563 chr4:185651563 MLF1IP 0.83 13.55 0.6 1.22e-33 Blood protein levels; LUSC cis rs9811920 0.809 rs902159 chr3:99747445 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.33 -5.78 -0.3 1.73e-8 Axial length; LUSC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg00745463 chr17:30367425 LRRC37B -0.7 -8.52 -0.42 5.45e-16 Hip circumference adjusted for BMI; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg11494091 chr17:61959527 GH2 -0.71 -16.44 -0.67 6.32e-45 Prudent dietary pattern; LUSC trans rs71435601 0.657 rs4596008 chr2:21417576 C/T cg20757404 chr19:378427 NA -0.41 -6.33 -0.33 8.06e-10 Cholesterol, total; LUSC cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg01689657 chr7:91764605 CYP51A1 0.32 5.84 0.3 1.25e-8 Breast cancer; LUSC cis rs2908296 0.515 rs12673242 chr7:44207494 T/C cg03639919 chr7:44191311 GCK 0.35 5.66 0.3 3.33e-8 Body mass index; LUSC cis rs7940866 0.801 rs10894288 chr11:130808679 T/C cg12179176 chr11:130786555 SNX19 0.64 9.6 0.46 1.99e-19 Schizophrenia; LUSC cis rs7089973 0.668 rs7077148 chr10:116644896 A/G cg25233709 chr10:116636983 FAM160B1 0.37 6.17 0.32 1.93e-9 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7804356 1.000 rs4722644 chr7:26845386 C/A cg03456212 chr7:26904342 SKAP2 -0.55 -6.48 -0.33 3.36e-10 Type 1 diabetes; LUSC cis rs6967385 0.583 rs7811925 chr7:12351245 C/T cg06484146 chr7:12443880 VWDE 0.42 6.33 0.33 8e-10 Response to taxane treatment (placlitaxel); LUSC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg05082376 chr22:42548792 NA -0.42 -6.29 -0.33 1.01e-9 Schizophrenia; LUSC cis rs3857536 0.706 rs2157963 chr6:66945449 A/T cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs11608355 0.960 rs11066526 chr12:109854476 G/C cg19025524 chr12:109796872 NA -0.39 -6.1 -0.32 2.87e-9 Neuroticism; LUSC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg12463550 chr7:65579703 CRCP 0.43 6.17 0.32 1.96e-9 Aortic root size; LUSC trans rs2018683 1.000 rs160837 chr7:29012732 C/G cg19402173 chr7:128379420 CALU -0.57 -9.7 -0.47 9.52e-20 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09861958 chr15:40886425 CASC5 -0.41 -6.11 -0.32 2.85e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12980942 0.935 rs12980480 chr19:41804655 A/G cg25627403 chr19:41769009 HNRNPUL1 0.62 6.73 0.35 7.24e-11 Coronary artery disease; LUSC cis rs911119 0.908 rs12624424 chr20:23601878 C/T cg16589663 chr20:23618590 CST3 0.61 7.33 0.37 1.75e-12 Chronic kidney disease; LUSC cis rs11048434 0.736 rs12821842 chr12:9108984 G/A cg23795048 chr12:9217529 LOC144571 0.34 5.94 0.31 7.05e-9 Sjögren's syndrome; LUSC cis rs7091068 0.671 rs620890 chr10:95405424 G/A cg20715218 chr10:95462985 C10orf4 -0.61 -7.16 -0.36 5.32e-12 Urinary tract infection frequency; LUSC cis rs2932538 0.961 rs4240534 chr1:113175429 T/A cg22162597 chr1:113214053 CAPZA1 -0.69 -9.87 -0.48 2.41e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs2075165 0.901 rs2296374 chr1:156287403 T/C cg20302342 chr1:156215951 PAQR6 0.33 6.29 0.33 9.79e-10 Tonsillectomy; LUSC trans rs225245 0.782 rs225293 chr17:33925906 A/G cg19694781 chr19:47549865 TMEM160 -0.42 -6.65 -0.34 1.18e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg22963979 chr7:1858916 MAD1L1 -0.59 -9.12 -0.45 6.98e-18 Bipolar disorder and schizophrenia; LUSC cis rs4474465 0.688 rs4945302 chr11:78283454 T/C cg27205649 chr11:78285834 NARS2 0.56 6.83 0.35 4.11e-11 Alzheimer's disease (survival time); LUSC cis rs96067 0.805 rs12033825 chr1:36600311 C/T cg24686825 chr1:36642396 MAP7D1 -0.68 -9.31 -0.45 1.75e-18 Corneal structure; LUSC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg24675056 chr1:15929824 NA 0.48 8.25 0.41 3.58e-15 Systolic blood pressure; LUSC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg18904891 chr8:8559673 CLDN23 0.61 8.15 0.41 7.22e-15 Obesity-related traits; LUSC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg01283332 chr5:1856932 NA -0.33 -6.23 -0.32 1.39e-9 Cardiovascular disease risk factors; LUSC cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg18132916 chr6:79620363 NA -0.38 -5.78 -0.3 1.74e-8 Intelligence (multi-trait analysis); LUSC cis rs243505 0.898 rs243528 chr7:148415740 T/C cg09806900 chr7:148480153 CUL1 -0.46 -6.63 -0.34 1.3100000000000001e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg21132104 chr15:45694354 SPATA5L1 0.57 7.96 0.4 2.63e-14 Homoarginine levels; LUSC cis rs950169 0.579 rs881983 chr15:84647308 C/T cg17173187 chr15:85201210 NMB 0.36 5.96 0.31 6.34e-9 Schizophrenia; LUSC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg09365446 chr1:150670422 GOLPH3L 0.48 7.06 0.36 9.95e-12 Melanoma; LUSC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg07424592 chr7:64974309 NA -0.64 -5.73 -0.3 2.24e-8 Diabetic kidney disease; LUSC cis rs67696533 0.600 rs6141745 chr20:31108805 T/A cg13636640 chr20:31349939 DNMT3B 0.47 6.25 0.32 1.24e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg22920501 chr2:26401640 FAM59B 0.82 11.98 0.55 9.28e-28 Gut microbiome composition (summer); LUSC cis rs6121246 0.528 rs6060252 chr20:30191084 A/G cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.82e-10 Mean corpuscular hemoglobin; LUSC trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg08219700 chr8:58056026 NA 0.46 6.12 0.32 2.59e-9 Developmental language disorder (linguistic errors); LUSC cis rs4834770 1.000 rs4834771 chr4:120242772 C/A cg24375607 chr4:120327624 NA 0.41 5.84 0.3 1.26e-8 Blood protein levels; LUSC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg14895029 chr7:2775587 GNA12 -0.43 -6.77 -0.35 5.78e-11 Height; LUSC cis rs61931739 0.500 rs11053198 chr12:34444013 G/C cg06521331 chr12:34319734 NA -0.41 -6.74 -0.35 6.92e-11 Morning vs. evening chronotype; LUSC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg02034447 chr16:89574710 SPG7 0.4 5.89 0.31 9.64e-9 Multiple myeloma (IgH translocation); LUSC cis rs9399135 0.967 rs12661423 chr6:135349570 C/T cg24558204 chr6:135376177 HBS1L 0.6 9.57 0.46 2.56e-19 Red blood cell count; LUSC cis rs6669008 1.000 rs55912359 chr1:114167099 C/T cg26035817 chr1:114414802 PTPN22 0.43 6.66 0.34 1.16e-10 Bacteremia; LUSC cis rs7809950 0.953 rs2520263 chr7:107179119 T/C cg23024343 chr7:107201750 COG5 -0.56 -8.77 -0.43 9.38e-17 Coronary artery disease; LUSC cis rs7917772 0.582 rs4408249 chr10:104374653 T/A cg22532475 chr10:104410764 TRIM8 -0.25 -5.85 -0.31 1.14e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg15704280 chr7:45808275 SEPT13 0.82 9.19 0.45 4.33e-18 Axial length; LUSC cis rs9296092 0.538 rs62405953 chr6:33524760 C/T cg13560919 chr6:33536144 NA -0.84 -16.05 -0.66 2.25e-43 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9303401 0.614 rs34920953 chr17:56589406 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.53 0.57 8.99e-30 Cognitive test performance; LUSC trans rs853679 0.607 rs13199649 chr6:27868792 C/T cg09904177 chr6:26538194 HMGN4 -0.82 -5.95 -0.31 6.72e-9 Depression; LUSC cis rs6582630 0.599 rs12824838 chr12:38373584 G/T cg13010199 chr12:38710504 ALG10B -0.44 -6.59 -0.34 1.74e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs2730245 0.527 rs1188974 chr7:158665748 C/T cg24397884 chr7:158709396 WDR60 0.77 8.8 0.43 7.36e-17 Height; LUSC cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg22532475 chr10:104410764 TRIM8 0.37 7.86 0.39 5.44e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs28374715 0.662 rs113913466 chr15:41483100 A/G cg18705301 chr15:41695430 NDUFAF1 -0.86 -15.32 -0.64 1.68e-40 Ulcerative colitis; LUSC cis rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05901451 chr6:126070800 HEY2 -0.76 -12.51 -0.56 1.02e-29 Endometrial cancer; LUSC cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg05347473 chr6:146136440 FBXO30 -0.49 -8.37 -0.42 1.58e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7712401 0.601 rs34707663 chr5:122320463 A/G cg19077854 chr5:122220652 SNX24 -0.43 -9.52 -0.46 3.69e-19 Mean platelet volume; LUSC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.23 0.49 1.53e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg00129232 chr17:37814104 STARD3 -0.49 -7.32 -0.37 1.84e-12 Asthma; LUSC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg22823121 chr1:150693482 HORMAD1 0.49 7.03 0.36 1.17e-11 Melanoma; LUSC trans rs8072100 0.701 rs10163469 chr17:45687767 G/A cg04995722 chr7:26192034 NFE2L3 0.37 6.15 0.32 2.24e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs3736594 0.546 rs6719960 chr2:27830067 C/T cg27432699 chr2:27873401 GPN1 -0.62 -8.69 -0.43 1.61e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg26597838 chr10:835615 NA 0.84 11.59 0.54 2.38e-26 Eosinophil percentage of granulocytes; LUSC cis rs4499344 0.696 rs398990 chr19:33104244 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 13.07 0.58 8.21e-32 Mean platelet volume; LUSC cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg23788917 chr6:8435910 SLC35B3 0.5 7.48 0.38 6.59e-13 Motion sickness; LUSC cis rs11098499 0.865 rs10032158 chr4:120391632 C/T cg09307838 chr4:120376055 NA 0.78 11.14 0.52 1.05e-24 Corneal astigmatism; LUSC cis rs9902453 1.000 rs4465650 chr17:28396721 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 8.11 0.41 9.96e-15 Coffee consumption (cups per day); LUSC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg26513180 chr16:89883248 FANCA 0.58 8.63 0.43 2.5e-16 Hemoglobin concentration; LUSC cis rs2455601 0.882 rs11042115 chr11:8926679 A/C cg09997546 chr11:8931473 C11orf17;ST5 -0.49 -7.8 -0.39 8.18e-14 Schizophrenia; LUSC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg20887711 chr4:1340912 KIAA1530 0.44 6.64 0.34 1.28e-10 Obesity-related traits; LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg22963979 chr7:1858916 MAD1L1 -0.58 -9.04 -0.44 1.3e-17 Bipolar disorder and schizophrenia; LUSC cis rs7264396 0.887 rs224344 chr20:34036865 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.68 -0.34 9.95e-11 Total cholesterol levels; LUSC cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg05283184 chr6:79620031 NA -0.57 -12.2 -0.56 1.41e-28 Intelligence (multi-trait analysis); LUSC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC trans rs7726839 0.526 rs11960159 chr5:568685 C/T cg25482853 chr8:67687455 SGK3 0.98 15.98 0.66 4.41e-43 Obesity-related traits; LUSC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg01879757 chr17:41196368 BRCA1 -0.45 -6.84 -0.35 3.68e-11 Menopause (age at onset); LUSC cis rs950169 0.922 rs11633075 chr15:85113972 C/A cg11189052 chr15:85197271 WDR73 0.47 5.8 0.3 1.54e-8 Schizophrenia; LUSC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg11752832 chr7:134001865 SLC35B4 0.56 8.78 0.43 8.84e-17 Mean platelet volume; LUSC cis rs4561483 0.767 rs33633 chr16:11994857 A/C cg08843971 chr16:11963173 GSPT1 -0.46 -6.88 -0.35 2.98e-11 Testicular germ cell tumor; LUSC cis rs9398803 0.966 rs9388487 chr6:126678268 G/T cg19875578 chr6:126661172 C6orf173 0.41 6.01 0.31 4.82e-9 Male-pattern baldness; LUSC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg09034736 chr1:150693464 HORMAD1 0.43 6.01 0.31 4.88e-9 Melanoma; LUSC cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.49 7.02 0.36 1.26e-11 Colorectal cancer; LUSC cis rs3849570 1.000 rs13088000 chr3:81839404 T/C cg07356753 chr3:81810745 GBE1 -0.67 -10.39 -0.49 4.22e-22 Waist circumference;Body mass index; LUSC cis rs17253792 0.822 rs17832371 chr14:56162302 C/A cg01858014 chr14:56050164 KTN1 -0.85 -6.82 -0.35 4.29e-11 Putamen volume; LUSC cis rs3772130 0.962 rs11707518 chr3:121496568 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 9.88 0.48 2.38e-20 Cognitive performance; LUSC trans rs1005277 0.579 rs2505240 chr10:38442419 G/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.59 -0.46 2.1e-19 Extrinsic epigenetic age acceleration; LUSC cis rs738322 0.772 rs9619724 chr22:38517880 T/G cg25457927 chr22:38595422 NA -0.35 -6.88 -0.35 3.01e-11 Cutaneous nevi; LUSC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg05855489 chr10:104503620 C10orf26 -0.68 -10.15 -0.49 2.8e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg12923728 chr3:195709715 SDHAP1 -0.8 -12.57 -0.57 6.25e-30 Pancreatic cancer; LUSC cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -8.3 -0.41 2.64e-15 Schizophrenia; LUSC cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg06784218 chr1:46089804 CCDC17 0.48 9.58 0.46 2.28e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1865760 0.566 rs2051544 chr6:26071093 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 8.11 0.41 9.7e-15 Height; LUSC cis rs701145 0.938 rs701131 chr3:154086138 C/G cg17054900 chr3:154042577 DHX36 0.82 7.89 0.4 4.37e-14 Coronary artery disease; LUSC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.95 -0.31 6.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg20500836 chr17:78818645 RPTOR -0.39 -6.12 -0.32 2.69e-9 N-glycan levels; LUSC trans rs11098499 0.863 rs2291185 chr4:120434833 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.58 0.34 1.84e-10 Corneal astigmatism; LUSC trans rs2392780 0.536 rs2691039 chr8:128334662 A/G cg10897648 chr18:56338258 MALT1 -0.4 -6.13 -0.32 2.43e-9 Breast cancer (early onset); LUSC cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg15556689 chr8:8085844 FLJ10661 -0.56 -8.34 -0.42 1.99e-15 Joint mobility (Beighton score); LUSC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg05110241 chr16:68378359 PRMT7 -0.56 -6.6 -0.34 1.61e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs9929218 0.954 rs9925923 chr16:68819614 C/T cg02972257 chr16:68554789 NA 0.44 6.03 0.31 4.25e-9 Colorectal cancer; LUSC trans rs393155 0.517 rs330050 chr8:9087679 G/C cg15556689 chr8:8085844 FLJ10661 -0.56 -8.47 -0.42 7.93e-16 Neuroticism; LUSC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg26924012 chr15:45694286 SPATA5L1 1.11 20.76 0.75 4.48e-62 Homoarginine levels; LUSC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg20243544 chr17:37824526 PNMT 0.49 6.87 0.35 3.19e-11 Asthma; LUSC cis rs5769765 1.000 rs2295409 chr22:50261060 G/C cg22709217 chr22:50311962 ALG12;CRELD2 0.81 10.59 0.5 8.51e-23 Schizophrenia; LUSC cis rs3743104 0.534 rs11854391 chr15:33022582 A/T cg07179000 chr15:33023586 GREM1 -0.32 -6.17 -0.32 2e-9 Hypospadias; LUSC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg15147215 chr3:52552868 STAB1 -0.33 -6.59 -0.34 1.67e-10 Electroencephalogram traits; LUSC cis rs1957429 0.901 rs7141985 chr14:65345670 C/T cg23373153 chr14:65346875 NA 1.08 12.07 0.55 4.21e-28 Pediatric areal bone mineral density (radius); LUSC trans rs76248362 0.748 rs943061 chr13:24431968 C/T cg26511321 chr7:27196790 HOXA7 -0.67 -7.85 -0.39 5.86e-14 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs713587 0.806 rs6737082 chr2:25138040 A/C cg04586622 chr2:25135609 ADCY3 0.35 7.3 0.37 2.08e-12 Body mass index in non-asthmatics; LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg07362569 chr17:61921086 SMARCD2 0.37 7.6 0.38 3.11e-13 Prudent dietary pattern; LUSC cis rs10979 1.000 rs34960207 chr6:143886398 C/T cg25407410 chr6:143891975 LOC285740 -0.74 -11.96 -0.55 1.14e-27 Hypospadias; LUSC trans rs7618501 0.633 rs2252833 chr3:50004209 C/T cg21659725 chr3:3221576 CRBN 0.64 10.33 0.49 7e-22 Intelligence (multi-trait analysis); LUSC cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg17971929 chr21:40555470 PSMG1 -0.48 -7.14 -0.36 5.77e-12 Menarche (age at onset); LUSC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg16520312 chr17:43971471 MAPT;LOC100128977 -0.38 -6.43 -0.33 4.29e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs600231 0.708 rs2957269 chr11:65243007 C/G cg17120908 chr11:65337727 SSSCA1 -0.53 -9.23 -0.45 3.22e-18 Bone mineral density; LUSC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg03433033 chr1:76189801 ACADM 0.79 11.37 0.53 1.56e-25 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7172677 0.768 rs34180494 chr15:75370012 A/C cg14664628 chr15:75095509 CSK 0.5 6.43 0.33 4.44e-10 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs540254 0.647 rs474918 chr1:160771197 C/T cg20255094 chr1:160771763 LY9 -0.49 -6.03 -0.31 4.45e-9 Blood protein levels; LUSC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg12432903 chr7:1882776 MAD1L1 -0.39 -6.26 -0.32 1.16e-9 Bipolar disorder and schizophrenia; LUSC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg05025164 chr4:1340916 KIAA1530 -0.51 -7.7 -0.39 1.52e-13 Obesity-related traits; LUSC cis rs7107174 1.000 rs11237462 chr11:78058812 C/A cg02023728 chr11:77925099 USP35 0.46 6.67 0.34 1.04e-10 Testicular germ cell tumor; LUSC cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg05347473 chr6:146136440 FBXO30 0.57 9.95 0.48 1.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7178572 0.568 rs11072653 chr15:77693934 C/T cg22256960 chr15:77711686 NA -0.5 -7.9 -0.4 4.04e-14 Type 2 diabetes; LUSC cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg23711669 chr6:146136114 FBXO30 -0.87 -16.79 -0.68 2.73e-46 Lobe attachment (rater-scored or self-reported); LUSC trans rs724744 0.772 rs1737230 chr6:22352366 C/T cg13807341 chr11:118445984 ARCN1 -0.36 -6.2 -0.32 1.67e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg06238570 chr21:40685208 BRWD1 0.46 7.1 0.36 7.78e-12 Cognitive function; LUSC trans rs330071 0.686 rs10087406 chr8:9246598 C/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.33 -0.41 2.08e-15 Acne (severe); LUSC cis rs7572733 0.534 rs700692 chr2:198728500 T/C cg00792783 chr2:198669748 PLCL1 0.43 5.68 0.3 2.9e-8 Dermatomyositis; LUSC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg19318889 chr4:1322082 MAEA -0.78 -15.03 -0.64 2.36e-39 Longevity; LUSC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg00933542 chr6:150070202 PCMT1 0.31 6.49 0.33 3.1e-10 Lung cancer; LUSC cis rs9325144 0.624 rs7979541 chr12:39129679 T/C cg13010199 chr12:38710504 ALG10B -0.47 -7.23 -0.37 3.3e-12 Morning vs. evening chronotype; LUSC cis rs4363385 0.510 rs55959888 chr1:152913490 A/G cg25856811 chr1:152973957 SPRR3 -0.38 -6.11 -0.32 2.84e-9 Inflammatory skin disease; LUSC cis rs899997 1.000 rs11634628 chr15:79005579 G/A cg04896959 chr15:78267971 NA 0.52 11.25 0.52 4.02e-25 Coronary artery disease or large artery stroke; LUSC cis rs763121 1.000 rs138457 chr22:38898051 T/C cg06022373 chr22:39101656 GTPBP1 -0.76 -12.25 -0.56 9.51e-29 Menopause (age at onset); LUSC cis rs921968 0.565 rs2037622 chr2:219609440 T/C cg02176678 chr2:219576539 TTLL4 -0.58 -10.17 -0.49 2.38e-21 Mean corpuscular hemoglobin concentration; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg20376421 chr12:56546193 MYL6B -0.52 -6.47 -0.33 3.48e-10 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.79e-30 Prudent dietary pattern; LUSC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg03929089 chr4:120376271 NA -0.95 -16.62 -0.67 1.21e-45 Height; LUSC cis rs9487051 0.768 rs2483913 chr6:109521042 G/A cg00509249 chr6:109615579 CCDC162 -0.33 -5.79 -0.3 1.66e-8 Reticulocyte fraction of red cells; LUSC cis rs12410462 0.581 rs75219436 chr1:227546617 C/T cg04117972 chr1:227635322 NA 0.6 6.68 0.34 1e-10 Major depressive disorder; LUSC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg21724239 chr8:58056113 NA 0.58 6.65 0.34 1.21e-10 Developmental language disorder (linguistic errors); LUSC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs2109514 1.000 rs2109514 chr7:116159961 G/A cg12739419 chr7:116140593 CAV2 -0.28 -6.24 -0.32 1.31e-9 Prevalent atrial fibrillation; LUSC cis rs4722404 0.556 rs765728 chr7:3153564 A/G cg19214707 chr7:3157722 NA -0.4 -7.24 -0.37 3.02e-12 Atopic dermatitis; LUSC cis rs2262909 0.962 rs73019889 chr19:22277826 C/G cg11619707 chr19:22235551 ZNF257 0.39 5.79 0.3 1.63e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs2219968 1.000 rs2219968 chr8:78956658 G/A cg00738934 chr8:78996279 NA 0.35 6.32 0.33 8.23e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs6121246 0.542 rs6059761 chr20:30110522 G/C cg13852791 chr20:30311386 BCL2L1 0.69 7.86 0.4 5.23e-14 Mean corpuscular hemoglobin; LUSC cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -6.75 -0.35 6.69e-11 Menopause (age at onset); LUSC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg07677032 chr17:61819896 STRADA 0.54 9.03 0.44 1.36e-17 Prudent dietary pattern; LUSC cis rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08231603 chr6:135818959 AHI1;C6orf217 -0.42 -6.47 -0.33 3.49e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3540 0.576 rs10152871 chr15:91047469 G/A cg03599575 chr15:90893182 GABARAPL3 -0.34 -5.8 -0.3 1.51e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6847149 0.866 rs9918080 chr4:110808051 G/A cg07850274 chr4:110748770 RRH 0.53 7.5 0.38 5.87e-13 Exercise treadmill test traits; LUSC cis rs1559088 0.948 rs9304844 chr19:33579935 G/T cg17764715 chr19:33622953 WDR88 0.61 8.31 0.41 2.45e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1018836 0.700 rs7824376 chr8:91521498 T/C cg16814680 chr8:91681699 NA -0.73 -11.41 -0.53 1.05e-25 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg14092988 chr3:52407081 DNAH1 0.3 5.8 0.3 1.53e-8 Bipolar disorder; LUSC cis rs35146811 0.844 rs34031156 chr7:99677917 T/A cg22906224 chr7:99728672 NA 0.52 7.62 0.38 2.71e-13 Coronary artery disease; LUSC cis rs9818941 0.826 rs2673547 chr3:157646627 A/G cg08654915 chr3:157813417 NA 0.28 6.43 0.33 4.31e-10 Height; LUSC trans rs2797160 0.967 rs80303782 chr6:126004193 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.43 -6.19 -0.32 1.78e-9 Endometrial cancer; LUSC cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg06671706 chr8:8559999 CLDN23 0.49 6.52 0.34 2.66e-10 Obesity-related traits; LUSC cis rs2625529 0.617 rs8025939 chr15:72460339 T/A cg16672083 chr15:72433130 SENP8 0.48 7.92 0.4 3.5e-14 Red blood cell count; LUSC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg05872129 chr22:39784769 NA 0.56 10.15 0.49 2.72e-21 IgG glycosylation; LUSC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 21.9 0.77 1.58e-66 Prudent dietary pattern; LUSC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg07806771 chr7:64541737 NA 0.43 6.03 0.31 4.29e-9 Calcium levels; LUSC cis rs4631830 0.737 rs7071471 chr10:51503335 C/T cg20129853 chr10:51489980 NA 0.35 6.87 0.35 3.07e-11 Prostate-specific antigen levels; LUSC cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg00530320 chr1:46809349 NSUN4 0.56 8.7 0.43 1.57e-16 Menopause (age at onset); LUSC cis rs3858526 0.792 rs12363478 chr11:5987775 C/T cg05234568 chr11:5960015 NA -0.62 -8.78 -0.43 8.47e-17 DNA methylation (variation); LUSC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg11645453 chr3:52864694 ITIH4 0.33 7.81 0.39 7.22e-14 Bipolar disorder; LUSC cis rs6977660 0.598 rs10239147 chr7:19787459 T/C cg07541023 chr7:19748670 TWISTNB 0.66 7.04 0.36 1.11e-11 Thyroid stimulating hormone; LUSC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg24257776 chr3:47051546 LOC100129354 -0.33 -5.77 -0.3 1.8e-8 Colorectal cancer; LUSC cis rs6543140 0.929 rs7602207 chr2:103032366 C/G cg09003973 chr2:102972529 NA 0.57 7.44 0.38 8.7e-13 Blood protein levels; LUSC cis rs11809443 0.569 rs11800309 chr1:228391808 G/T cg18477163 chr1:228402036 OBSCN 0.51 7.21 0.37 3.72e-12 Coronary artery disease; LUSC cis rs8063160 0.756 rs35749174 chr16:89716493 G/A cg07984980 chr16:89898383 SPIRE2 0.85 6.4 0.33 5.27e-10 Red vs non-red hair color;Light vs. dark hair color;Brown vs. non-brown hair color; LUSC cis rs11250098 0.600 rs4240671 chr8:10767748 A/G cg21775007 chr8:11205619 TDH 0.48 6.86 0.35 3.38e-11 Morning vs. evening chronotype; LUSC cis rs617219 0.726 rs3733893 chr5:78532658 C/T cg24856658 chr5:78533917 JMY -0.3 -5.85 -0.3 1.18e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg04545296 chr12:48745243 ZNF641 -0.35 -6.52 -0.34 2.6e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg07424592 chr7:64974309 NA 0.7 6.15 0.32 2.24e-9 Diabetic kidney disease; LUSC cis rs1443512 1.000 rs1443512 chr12:54342684 A/C cg17410650 chr12:54324560 NA -0.43 -6.77 -0.35 5.9e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs62283056 0.512 rs752854 chr4:6281961 C/T cg14416269 chr4:6271139 WFS1 0.45 8.36 0.42 1.78e-15 Cisplatin-induced ototoxicity; LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg27535305 chr1:53392650 SCP2 0.41 7.87 0.4 5.07e-14 Monocyte count; LUSC cis rs11583043 0.667 rs873760 chr1:101540561 C/A cg11406453 chr1:101602562 NA -0.38 -6.33 -0.33 8.05e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg13114125 chr14:105738426 BRF1 -0.92 -15.61 -0.65 1.22e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs11031096 0.502 rs7935824 chr11:4046900 C/G cg08557956 chr11:4115526 RRM1 -0.49 -6.23 -0.32 1.42e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg14004847 chr7:1930337 MAD1L1 -0.46 -6.82 -0.35 4.38e-11 Bipolar disorder and schizophrenia; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg13412866 chr18:20715409 CABLES1 -0.4 -6.19 -0.32 1.79e-9 Electrocardiographic conduction measures; LUSC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg27170947 chr2:26402098 FAM59B 0.64 8.17 0.41 6.58e-15 Gut microbiome composition (summer); LUSC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg22467129 chr15:76604101 ETFA 0.43 7.04 0.36 1.1e-11 Blood metabolite levels; LUSC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.23 0.41 4.34e-15 Prudent dietary pattern; LUSC cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg11189052 chr15:85197271 WDR73 0.5 6.32 0.33 8.21e-10 Schizophrenia; LUSC cis rs2439831 1.000 rs28628574 chr15:43802038 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.09 0.4 1.13e-14 Lung cancer in ever smokers; LUSC cis rs10492096 1.000 rs10492096 chr12:6580582 A/G cg13857086 chr12:6580257 VAMP1 0.84 9.31 0.45 1.73e-18 Hip geometry; LUSC cis rs13315871 1.000 rs4367085 chr3:58389235 A/G cg20936604 chr3:58311152 NA -0.67 -6.29 -0.33 9.73e-10 Cholesterol, total; LUSC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg06808227 chr14:105710500 BRF1 -0.65 -10.24 -0.49 1.4e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg04944784 chr2:26401820 FAM59B 0.71 10.06 0.48 5.72e-21 Gut microbiome composition (summer); LUSC cis rs1568889 1.000 rs7937117 chr11:28370038 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 9.44 0.46 6.68e-19 Bipolar disorder; LUSC cis rs10740039 0.516 rs6479717 chr10:62319288 G/C cg18175470 chr10:62150864 ANK3 -0.47 -6.95 -0.36 1.97e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs66569888 0.789 rs1317569 chr2:106735490 C/A cg16099169 chr2:106886729 NA -0.55 -7.15 -0.36 5.34e-12 Facial morphology (factor 23); LUSC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.42 6.82 0.35 4.41e-11 Electroencephalogram traits; LUSC cis rs12410462 0.681 rs78978081 chr1:227571619 G/A cg04117972 chr1:227635322 NA 0.61 6.54 0.34 2.3e-10 Major depressive disorder; LUSC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg24468199 chr11:65410028 SIPA1 -0.49 -6.83 -0.35 4.04e-11 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; LUSC cis rs1007190 0.881 rs8073674 chr17:42969337 A/C cg15406952 chr17:42872593 NA 0.56 5.76 0.3 1.88e-8 DNA methylation (variation); LUSC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg11752832 chr7:134001865 SLC35B4 0.56 8.65 0.43 2.2e-16 Mean platelet volume; LUSC cis rs9549260 0.816 rs7324090 chr13:41253958 A/T cg21288729 chr13:41239152 FOXO1 0.57 8.5 0.42 6.36e-16 Red blood cell count; LUSC cis rs2806561 0.695 rs67238799 chr1:23335012 G/A cg12483005 chr1:23474871 LUZP1 0.41 6.09 0.32 3.03e-9 Height; LUSC cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg08999081 chr20:33150536 PIGU 0.55 11.08 0.52 1.6e-24 Coronary artery disease; LUSC cis rs1799949 1.000 rs11659028 chr17:41195025 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.66 0.5 5.03e-23 Menopause (age at onset); LUSC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.46 7.83 0.39 6.4e-14 Lymphocyte counts; LUSC cis rs4253772 0.938 rs41355347 chr22:46637511 G/A cg18190219 chr22:46762943 CELSR1 -0.52 -5.87 -0.31 1.06e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs1044826 1.000 rs9868544 chr3:139163154 C/T cg00490450 chr3:139108681 COPB2 0.54 7.06 0.36 9.67e-12 Obesity-related traits; LUSC cis rs9527 0.590 rs3861984 chr10:104916980 T/C cg05855489 chr10:104503620 C10orf26 0.52 7.9 0.4 4.02e-14 Arsenic metabolism; LUSC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.17 -0.32 2.03e-9 Life satisfaction; LUSC cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.56 -8.11 -0.41 9.59e-15 Axial length; LUSC cis rs2439831 0.867 rs2245715 chr15:43818052 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.8 8.2 0.41 5.22e-15 Lung cancer in ever smokers; LUSC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg02931644 chr1:25747376 RHCE 0.32 5.76 0.3 1.89e-8 Erythrocyte sedimentation rate; LUSC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.86 0.44 4.92e-17 Prudent dietary pattern; LUSC cis rs61869271 0.871 rs6585308 chr10:116727532 G/A cg23260525 chr10:116636907 FAM160B1 0.31 5.99 0.31 5.58e-9 Tonsillectomy; LUSC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg00814883 chr7:100076585 TSC22D4 -0.75 -10.33 -0.49 7.12e-22 Platelet count; LUSC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg13072238 chr3:49761600 GMPPB -0.65 -7.74 -0.39 1.17e-13 Menarche (age at onset); LUSC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg13453750 chr1:205783389 SLC41A1 -0.32 -6.34 -0.33 7.49e-10 Menarche (age at onset); LUSC cis rs67539049 1.000 rs67684445 chr8:11297327 C/T cg02771117 chr8:11279352 FAM167A;C8orf12 -0.38 -5.81 -0.3 1.43e-8 Itch intensity from mosquito bite; LUSC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.77 -0.39 9.62e-14 Height; LUSC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg20243544 chr17:37824526 PNMT 0.4 6.03 0.31 4.26e-9 Self-reported allergy; LUSC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg05802129 chr4:122689817 NA -0.34 -6.0 -0.31 5.12e-9 Type 2 diabetes; LUSC cis rs1003719 0.762 rs2835598 chr21:38466669 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.33 0.53 2.17e-25 Eye color traits; LUSC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg24468199 chr11:65410028 SIPA1 -0.49 -7.23 -0.37 3.4e-12 Blood pressure (age interaction); LUSC cis rs116988415 1.000 rs116988415 chr14:65292145 C/T cg25083366 chr14:65239357 SPTB 0.64 6.05 0.31 3.98e-9 Daytime sleep phenotypes; LUSC cis rs7707921 0.767 rs862244 chr5:81586801 G/A cg15871215 chr5:81402204 ATG10 0.45 7.07 0.36 8.95e-12 Breast cancer; LUSC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg05623727 chr3:50126028 RBM5 0.32 6.04 0.31 4.04e-9 Intelligence (multi-trait analysis); LUSC cis rs11051970 0.636 rs1045751 chr12:32569496 T/C cg02745156 chr12:32552066 NA 0.39 7.09 0.36 8.27e-12 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs62400317 0.859 rs62438864 chr6:45041787 G/A cg18551225 chr6:44695536 NA -0.42 -6.84 -0.35 3.83e-11 Total body bone mineral density; LUSC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18404041 chr3:52824283 ITIH1 -0.55 -10.72 -0.51 3.15e-23 Bipolar disorder; LUSC cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -8.55 -0.42 4.48e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs478607 1.000 rs60159753 chr11:64479112 G/T cg19131476 chr11:64387923 NRXN2 0.34 6.16 0.32 2.11e-9 Urate levels; LUSC trans rs3942852 0.868 rs6485808 chr11:48109151 A/G cg03929089 chr4:120376271 NA -0.54 -6.21 -0.32 1.62e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg13206674 chr6:150067644 NUP43 0.56 8.59 0.43 3.41e-16 Lung cancer; LUSC trans rs7980799 0.935 rs1905408 chr12:33516963 G/A cg26384229 chr12:38710491 ALG10B -0.42 -5.98 -0.31 5.84e-9 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs67981189 0.613 rs4531677 chr14:71451861 A/G cg15816911 chr14:71606274 NA 0.35 6.19 0.32 1.75e-9 Schizophrenia; LUSC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11890956 chr21:40555474 PSMG1 -0.83 -14.73 -0.63 3.56e-38 Cognitive function; LUSC cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg12573674 chr2:1569213 NA -0.55 -7.85 -0.39 5.76e-14 IgG glycosylation; LUSC cis rs6688613 0.694 rs2075946 chr1:166818566 A/G cg07049167 chr1:166818506 POGK 0.56 8.36 0.42 1.78e-15 Refractive astigmatism; LUSC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg11494091 chr17:61959527 GH2 -0.73 -17.44 -0.69 6.96e-49 Prudent dietary pattern; LUSC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg13395646 chr4:1353034 KIAA1530 -0.64 -10.17 -0.49 2.38e-21 Obesity-related traits; LUSC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.28 0.45 2.23e-18 Prudent dietary pattern; LUSC cis rs17401966 0.838 rs4846206 chr1:10310258 G/C cg19773385 chr1:10388646 KIF1B -0.51 -8.87 -0.44 4.4e-17 Hepatocellular carcinoma; LUSC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg26897989 chr16:1907736 C16orf73 -0.4 -6.43 -0.33 4.48e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs4363385 0.597 rs55667413 chr1:152976849 G/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.82 -0.39 6.89e-14 Inflammatory skin disease; LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg08888203 chr3:10149979 C3orf24 0.66 9.07 0.44 1.06e-17 Alzheimer's disease; LUSC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg12310025 chr6:25882481 NA 0.52 9.72 0.47 7.69e-20 Blood metabolite levels; LUSC cis rs7607369 0.536 rs4674344 chr2:219669875 A/T cg02176678 chr2:219576539 TTLL4 -0.52 -9.15 -0.45 5.72e-18 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg14784868 chr12:69753453 YEATS4 0.82 14.18 0.61 4.8e-36 Blood protein levels; LUSC cis rs73206853 0.544 rs55752061 chr12:111126096 G/C cg12870014 chr12:110450643 ANKRD13A 0.7 7.15 0.36 5.53e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6430585 0.528 rs12476127 chr2:136763242 A/G cg07169764 chr2:136633963 MCM6 1.16 18.64 0.71 1.15e-53 Corneal structure; LUSC cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg25643088 chr3:52874325 TMEM110 0.38 5.79 0.3 1.6e-8 Schizophrenia; LUSC cis rs7202877 0.610 rs8053632 chr16:75364940 C/T cg04384234 chr16:75411784 CFDP1 -0.63 -8.88 -0.44 4.22e-17 Type 2 diabetes;Type 1 diabetes; LUSC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg04871131 chr7:94954202 PON1 -0.39 -6.19 -0.32 1.72e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs968451 0.951 rs5757622 chr22:39728861 C/T cg17798944 chr22:39715225 SNORD43;RPL3 0.67 8.74 0.43 1.11e-16 Primary biliary cholangitis; LUSC cis rs6723108 0.651 rs35215000 chr2:135367656 C/A cg12500956 chr2:135428796 TMEM163 -0.29 -6.86 -0.35 3.28e-11 Type 2 diabetes; LUSC trans rs877282 0.898 rs34490091 chr10:765800 A/C cg22713356 chr15:30763199 NA 1.07 14.17 0.61 5.24e-36 Uric acid levels; LUSC cis rs2762353 0.935 rs2817188 chr6:25807603 A/G cg12310025 chr6:25882481 NA -0.43 -7.41 -0.38 1.06e-12 Blood metabolite levels; LUSC cis rs5758659 0.714 rs5758578 chr22:42490292 A/C cg00645731 chr22:42541494 CYP2D7P1 0.29 5.79 0.3 1.67e-8 Cognitive function; LUSC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.78 -9.98 -0.48 1.07e-20 Gut microbiome composition (summer); LUSC cis rs11098499 0.955 rs13113112 chr4:120156040 C/T cg24375607 chr4:120327624 NA 0.76 11.46 0.53 7.46e-26 Corneal astigmatism; LUSC trans rs7824557 0.628 rs34237267 chr8:11197301 G/C cg15556689 chr8:8085844 FLJ10661 0.48 7.21 0.37 3.87e-12 Retinal vascular caliber; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg02765045 chr12:53845774 PCBP2 0.45 6.07 0.32 3.46e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg09021430 chr5:549028 NA -0.53 -7.49 -0.38 6.08e-13 Lung disease severity in cystic fibrosis; LUSC cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs4478858 0.611 rs1007012 chr1:31710068 G/A cg00250761 chr1:31883323 NA -0.35 -8.5 -0.42 6.33e-16 Alcohol dependence; LUSC cis rs3818285 0.556 rs2084607 chr10:111681411 C/T cg00817464 chr10:111662876 XPNPEP1 0.62 9.25 0.45 2.65e-18 Superior crus of antihelix expression; LUSC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg13918804 chr1:2043761 PRKCZ 0.27 5.74 0.3 2.11e-8 Height; LUSC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.83 -13.37 -0.59 6.03e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg20307385 chr11:47447363 PSMC3 -0.45 -5.96 -0.31 6.38e-9 Subjective well-being; LUSC cis rs8092503 1.000 rs12964118 chr18:52495506 A/G cg12377874 chr18:52495404 RAB27B 0.33 5.99 0.31 5.54e-9 Childhood body mass index; LUSC cis rs983392 0.709 rs11826180 chr11:59991333 T/C cg20284999 chr11:59952153 MS4A6A -0.36 -6.09 -0.32 3.14e-9 Alzheimer's disease (late onset); LUSC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg11764359 chr7:65958608 NA -0.64 -10.54 -0.5 1.27e-22 Aortic root size; LUSC cis rs1570884 0.516 rs7334387 chr13:50172133 T/A cg03651054 chr13:50194643 NA 0.36 6.26 0.32 1.17e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; LUSC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg18032046 chr6:28092343 ZSCAN16 -0.49 -5.71 -0.3 2.5e-8 Depression; LUSC cis rs12681287 0.546 rs11539113 chr8:87497176 G/A cg27223183 chr8:87520930 FAM82B -0.54 -7.16 -0.36 5.3e-12 Caudate activity during reward; LUSC cis rs2710247 1 rs2710247 chr2:219467508 A/G cg02176678 chr2:219576539 TTLL4 0.6 10.72 0.51 3.14e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs2304069 0.826 rs245076 chr5:149350648 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.48 7.09 0.36 8.18e-12 HIV-1 control; LUSC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.39 5.9 0.31 9.15e-9 Intelligence (multi-trait analysis); LUSC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg06637938 chr14:75390232 RPS6KL1 0.53 8.6 0.43 3.04e-16 Height; LUSC cis rs12421382 0.659 rs12417251 chr11:109386273 G/T cg27471124 chr11:109292789 C11orf87 0.43 7.61 0.38 2.85e-13 Schizophrenia; LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg24642439 chr20:33292090 TP53INP2 0.68 10.74 0.51 2.66e-23 Coronary artery disease; LUSC cis rs7474896 0.515 rs2738203 chr10:38277596 G/A cg25427524 chr10:38739819 LOC399744 0.47 5.98 0.31 5.83e-9 Obesity (extreme); LUSC trans rs7739264 0.602 rs9350179 chr6:19764095 G/A cg13431028 chr2:169073609 STK39 0.37 6.23 0.32 1.39e-9 Endometriosis; LUSC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg03354898 chr7:1950403 MAD1L1 -0.33 -6.43 -0.33 4.53e-10 Bipolar disorder and schizophrenia; LUSC cis rs4478858 0.709 rs3766296 chr1:31820223 G/A cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.06 0.36 9.75e-12 Bipolar disorder; LUSC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg13798780 chr7:105162888 PUS7 0.56 6.19 0.32 1.81e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg06713675 chr4:122721982 EXOSC9 -0.56 -9.62 -0.47 1.74e-19 Type 2 diabetes; LUSC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg18681998 chr4:17616180 MED28 0.84 15.82 0.65 1.78e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs5769765 1.000 rs5769765 chr22:50271176 G/A cg08270630 chr22:50330655 NA 0.41 6.07 0.32 3.54e-9 Schizophrenia; LUSC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg26441486 chr22:50317300 CRELD2 0.48 7.11 0.36 7.27e-12 Schizophrenia; LUSC cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14240646 chr10:27532245 ACBD5 -0.68 -7.86 -0.4 5.19e-14 Breast cancer; LUSC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg15704280 chr7:45808275 SEPT13 -1.04 -18.06 -0.7 2.45e-51 Coronary artery disease; LUSC cis rs3806843 1.000 rs2098058 chr5:140157427 A/C cg26395211 chr5:140044315 WDR55 0.4 6.24 0.32 1.36e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs6076065 0.676 rs1419005 chr20:23336432 G/T cg11657817 chr20:23433608 CST11 -0.44 -8.2 -0.41 5.39e-15 Facial morphology (factor 15, philtrum width); LUSC cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.91 0.4 3.77e-14 Crohn's disease; LUSC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.9 15.94 0.66 6.17e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg16434002 chr17:42200994 HDAC5 -0.45 -6.44 -0.33 4.13e-10 Total body bone mineral density; LUSC cis rs7605827 0.930 rs2058866 chr2:15519992 G/T cg19274914 chr2:15703543 NA 0.45 8.78 0.43 8.82e-17 Educational attainment (years of education); LUSC cis rs727505 0.954 rs66526112 chr7:124504074 C/A cg23710748 chr7:124431027 NA -0.42 -7.61 -0.38 2.87e-13 Lewy body disease; LUSC cis rs3857536 0.740 rs9360191 chr6:66942454 A/T cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg06008330 chr7:65541103 ASL -0.4 -6.35 -0.33 6.96e-10 Aortic root size; LUSC cis rs34779708 0.733 rs59287215 chr10:35543994 C/T cg03585969 chr10:35415529 CREM 0.56 7.79 0.39 8.66e-14 Inflammatory bowel disease;Crohn's disease; LUSC cis rs854765 0.522 rs63721860 chr17:17829576 T/C cg09796270 chr17:17721594 SREBF1 0.41 7.2 0.37 4.03e-12 Total body bone mineral density; LUSC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg11752832 chr7:134001865 SLC35B4 0.51 7.78 0.39 9.29e-14 Mean platelet volume; LUSC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg13939156 chr17:80058883 NA -0.33 -6.57 -0.34 1.96e-10 Life satisfaction; LUSC cis rs6504663 0.558 rs7627 chr17:48552154 G/C cg03168497 chr17:48586147 MYCBPAP 0.53 6.98 0.36 1.59e-11 Visceral fat; LUSC cis rs3768617 0.510 rs12091137 chr1:183075732 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.09 0.52 1.54e-24 Fuchs's corneal dystrophy; LUSC cis rs765787 0.530 rs2433228 chr15:45515371 A/C cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.44e-17 Uric acid levels; LUSC cis rs40363 1.000 rs28401 chr16:3515354 C/G cg21433313 chr16:3507492 NAT15 0.79 9.93 0.48 1.58e-20 Tuberculosis; LUSC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.31 -0.33 8.89e-10 Total body bone mineral density; LUSC cis rs9549367 0.737 rs9549712 chr13:113902355 G/A cg00898013 chr13:113819073 PROZ -0.57 -8.06 -0.4 1.38e-14 Platelet distribution width; LUSC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg18876405 chr7:65276391 NA -0.56 -8.81 -0.43 7.03e-17 Aortic root size; LUSC cis rs2976388 0.692 rs2978983 chr8:143765842 A/G cg17252645 chr8:143867129 LY6D 0.38 6.65 0.34 1.2e-10 Urinary tract infection frequency; LUSC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg18190219 chr22:46762943 CELSR1 -0.49 -6.0 -0.31 5.16e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs6504663 0.586 rs60117965 chr17:48569755 G/A cg03611598 chr17:48586076 MYCBPAP 0.49 6.06 0.31 3.73e-9 Visceral fat; LUSC cis rs6687430 0.514 rs587916 chr1:10545590 G/A cg20482658 chr1:10539492 PEX14 -0.33 -6.71 -0.34 8.1e-11 Hand grip strength; LUSC cis rs13089785 0.965 rs12488058 chr3:123599681 C/T cg19611163 chr3:123411211 MYLK 0.35 5.85 0.3 1.15e-8 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg22535103 chr8:58192502 C8orf71 -0.74 -7.67 -0.39 1.95e-13 Developmental language disorder (linguistic errors); LUSC cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg04450456 chr4:17643702 FAM184B 0.41 6.68 0.34 9.96e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg06022373 chr22:39101656 GTPBP1 0.74 11.49 0.53 5.61e-26 Menopause (age at onset); LUSC cis rs7707921 0.767 rs178931 chr5:81575601 T/A cg15871215 chr5:81402204 ATG10 0.46 7.03 0.36 1.19e-11 Breast cancer; LUSC cis rs4780401 0.609 rs8055247 chr16:11827543 G/A cg01061890 chr16:11836724 TXNDC11 -0.54 -8.2 -0.41 5.19e-15 Rheumatoid arthritis; LUSC cis rs73195822 0.667 rs7967408 chr12:111164408 A/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.52 0.38 5.1e-13 Itch intensity from mosquito bite; LUSC cis rs9660180 0.934 rs12729990 chr1:1812035 T/A cg13866156 chr1:1669148 SLC35E2 -0.5 -8.05 -0.4 1.45e-14 Body mass index; LUSC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg06634786 chr22:41940651 POLR3H -0.58 -6.52 -0.34 2.61e-10 Vitiligo; LUSC cis rs28830936 1.000 rs2577960 chr15:42028354 C/A cg17847044 chr15:42102381 MAPKBP1 0.27 5.81 0.3 1.45e-8 Diastolic blood pressure; LUSC cis rs11122272 0.735 rs2572251 chr1:231514243 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.95 -0.48 1.39e-20 Hemoglobin concentration; LUSC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg27532560 chr4:187881888 NA -0.37 -6.07 -0.32 3.5e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9487051 0.768 rs371960 chr6:109525082 A/G cg01475377 chr6:109611718 NA -0.35 -5.94 -0.31 7.09e-9 Reticulocyte fraction of red cells; LUSC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg15704280 chr7:45808275 SEPT13 1.03 17.71 0.7 6.06e-50 Coronary artery disease; LUSC trans rs11039798 0.764 rs11039929 chr11:48703289 A/G cg15704280 chr7:45808275 SEPT13 0.82 7.82 0.39 6.96e-14 Axial length; LUSC cis rs6489882 0.607 rs4767033 chr12:113364382 T/A cg20102336 chr12:113376681 OAS3 -0.41 -5.89 -0.31 9.59e-9 Chronic lymphocytic leukemia; LUSC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg17173187 chr15:85201210 NMB -0.3 -6.35 -0.33 7.17e-10 Schizophrenia; LUSC trans rs11250097 0.507 rs2409779 chr8:11311340 A/T cg15556689 chr8:8085844 FLJ10661 -0.59 -8.14 -0.41 7.86e-15 Neuroticism; LUSC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg25319279 chr11:5960081 NA -0.41 -5.79 -0.3 1.64e-8 DNA methylation (variation); LUSC cis rs897080 0.515 rs786616 chr2:44592975 C/G cg00619915 chr2:44497795 NA -0.41 -5.92 -0.31 8.15e-9 Height; LUSC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg22800045 chr5:56110881 MAP3K1 -0.63 -7.93 -0.4 3.28e-14 Initial pursuit acceleration; LUSC trans rs6952808 0.609 rs6944877 chr7:1952582 T/G cg04565464 chr8:145669602 NFKBIL2 0.39 6.34 0.33 7.57e-10 Bipolar disorder and schizophrenia; LUSC cis rs5769707 0.521 rs6009810 chr22:50059540 A/G cg10356904 chr22:49881777 NA -0.3 -6.01 -0.31 4.92e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6964587 0.773 rs38793 chr7:92027187 A/G cg17063962 chr7:91808500 NA -0.54 -7.83 -0.39 6.64e-14 Breast cancer; LUSC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg17366294 chr4:99064904 C4orf37 0.56 9.84 0.47 3.25e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs854765 0.575 rs7207821 chr17:17891781 A/G cg04398451 chr17:18023971 MYO15A -0.57 -9.22 -0.45 3.34e-18 Total body bone mineral density; LUSC cis rs4363385 0.747 rs1611759 chr1:152957439 T/G cg00922841 chr1:152955080 SPRR1A -0.43 -7.51 -0.38 5.5e-13 Inflammatory skin disease; LUSC cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg00071950 chr4:10020882 SLC2A9 0.63 10.52 0.5 1.55e-22 Bone mineral density; LUSC cis rs1371867 0.726 rs1660333 chr8:101309989 A/G cg06002616 chr8:101225028 SPAG1 -0.45 -7.49 -0.38 6.08e-13 Atrioventricular conduction; LUSC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg12403142 chr1:92012408 NA -0.42 -6.77 -0.35 5.91e-11 Breast cancer; LUSC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg13393036 chr8:95962371 TP53INP1 -0.5 -10.92 -0.51 6.08e-24 Type 2 diabetes; LUSC cis rs61931739 0.517 rs12816423 chr12:34067736 G/A cg06521331 chr12:34319734 NA -0.48 -7.69 -0.39 1.65e-13 Morning vs. evening chronotype; LUSC cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg23711669 chr6:146136114 FBXO30 0.87 16.0 0.66 3.64e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs9611519 1.000 rs9611505 chr22:41540279 T/C cg03806693 chr22:41940476 POLR3H -0.54 -7.5 -0.38 5.85e-13 Neuroticism; LUSC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg12311346 chr5:56204834 C5orf35 -0.59 -9.39 -0.46 9.9e-19 Breast cancer;Breast cancer (early onset); LUSC cis rs7560272 0.538 rs12619258 chr2:73935915 G/T cg20560298 chr2:73613845 ALMS1 0.38 5.73 0.3 2.19e-8 Schizophrenia; LUSC cis rs34779708 0.966 rs2045917 chr10:35418526 G/A cg04310649 chr10:35416472 CREM -0.44 -6.87 -0.35 3.23e-11 Inflammatory bowel disease;Crohn's disease; LUSC trans rs9467711 0.659 rs13195509 chr6:26463660 C/T cg06606381 chr12:133084897 FBRSL1 -0.72 -6.62 -0.34 1.43e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs174551 1 rs174551 chr11:61573684 T/C cg19610905 chr11:61596333 FADS2 -0.55 -8.26 -0.41 3.54e-15 LDL cholesterol; LUSC cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg21535247 chr6:8435926 SLC35B3 0.57 8.92 0.44 3.02e-17 Motion sickness; LUSC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.45 6.48 0.33 3.25e-10 Breast cancer; LUSC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg19622623 chr12:86230825 RASSF9 -0.41 -5.73 -0.3 2.26e-8 Major depressive disorder; LUSC cis rs9361491 0.508 rs4706718 chr6:79416883 G/A cg05283184 chr6:79620031 NA -0.39 -6.91 -0.35 2.49e-11 Intelligence (multi-trait analysis); LUSC cis rs17401966 0.858 rs61778404 chr1:10432879 A/G cg19773385 chr1:10388646 KIF1B -0.59 -10.1 -0.48 4.34e-21 Hepatocellular carcinoma; LUSC cis rs75920871 0.588 rs1940626 chr11:116828121 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.53 -6.6 -0.34 1.61e-10 Subjective well-being; LUSC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg14784868 chr12:69753453 YEATS4 0.89 15.67 0.65 7.27e-42 Cerebrospinal fluid biomarker levels; LUSC trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg27661571 chr11:113659931 NA -0.61 -6.87 -0.35 3.09e-11 Hip circumference adjusted for BMI; LUSC cis rs782590 0.902 rs782595 chr2:55845596 C/G cg18811423 chr2:55921094 PNPT1 0.83 14.52 0.62 2.36e-37 Metabolic syndrome; LUSC cis rs2404602 0.647 rs12905181 chr15:77098431 A/G cg23625390 chr15:77176239 SCAPER -0.64 -9.88 -0.48 2.35e-20 Blood metabolite levels; LUSC cis rs9646944 0.501 rs10181785 chr2:103025274 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.6 0.34 1.65e-10 Blood protein levels; LUSC cis rs7572644 0.766 rs7587180 chr2:28176109 A/G cg27432699 chr2:27873401 GPN1 -0.52 -6.52 -0.34 2.64e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs4595586 0.545 rs7294600 chr12:39373416 A/G cg13010199 chr12:38710504 ALG10B 0.41 5.94 0.31 7.08e-9 Morning vs. evening chronotype; LUSC trans rs10411161 0.721 rs10401778 chr19:52384315 C/T cg22319618 chr22:45562946 NUP50 -0.49 -5.94 -0.31 6.97e-9 Breast cancer; LUSC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg13939156 chr17:80058883 NA -0.33 -6.65 -0.34 1.22e-10 Life satisfaction; LUSC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg24829409 chr8:58192753 C8orf71 -0.62 -7.38 -0.37 1.25e-12 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg13395646 chr4:1353034 KIAA1530 -0.81 -13.7 -0.6 3.27e-34 Obesity-related traits; LUSC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs4555082 0.874 rs56263609 chr14:105756944 C/T cg10792982 chr14:105748885 BRF1 0.49 8.35 0.42 1.78e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs7246967 0.673 rs55932152 chr19:22873428 A/T cg23217946 chr19:22817039 ZNF492 0.49 6.85 0.35 3.48e-11 Bronchopulmonary dysplasia; LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg01494348 chr8:144660395 NAPRT1 -0.68 -7.03 -0.36 1.19e-11 Attention deficit hyperactivity disorder; LUSC cis rs8060686 0.623 rs28700885 chr16:68154544 A/G cg26727032 chr16:67993705 SLC12A4 -0.4 -6.11 -0.32 2.84e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.69 -6.59 -0.34 1.7e-10 Cerebrospinal P-tau181p levels; LUSC cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg09184832 chr6:79620586 NA -0.43 -6.74 -0.35 7.09e-11 Intelligence (multi-trait analysis); LUSC cis rs77633900 0.772 rs2957560 chr15:76700310 A/T cg21673338 chr15:77095150 SCAPER -0.7 -5.99 -0.31 5.4e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -6.77 -0.35 5.7e-11 Major depressive disorder; LUSC cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg18490616 chr2:88469792 THNSL2 -0.61 -8.15 -0.41 7.36e-15 Response to metformin (IC50); LUSC cis rs7584330 0.704 rs72620821 chr2:238362615 C/A cg14458575 chr2:238380390 NA 0.86 15.27 0.64 2.74e-40 Prostate cancer; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06804154 chr1:109825675 PSRC1 -0.4 -5.98 -0.31 5.82e-9 Electrocardiographic conduction measures; LUSC cis rs478304 0.651 rs11227299 chr11:65549570 C/G cg10518572 chr11:65560635 OVOL1 -0.27 -6.19 -0.32 1.79e-9 Acne (severe); LUSC trans rs6445975 0.666 rs2070662 chr3:58415590 C/A cg18950693 chr14:70346909 SMOC1 -0.39 -5.99 -0.31 5.36e-9 Systemic lupus erythematosus; LUSC cis rs62103177 0.525 rs1835410 chr18:77702025 T/C cg20368463 chr18:77673604 PQLC1 -0.67 -6.78 -0.35 5.39e-11 Opioid sensitivity; LUSC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg12927641 chr6:109611667 NA -0.4 -6.92 -0.35 2.37e-11 Reticulocyte fraction of red cells; LUSC cis rs8114671 0.901 rs6119581 chr20:33773689 T/A cg24642439 chr20:33292090 TP53INP2 0.41 5.97 0.31 5.95e-9 Height; LUSC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.88e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs9653442 0.900 rs6740838 chr2:100813499 T/G cg22139774 chr2:100720529 AFF3 -0.45 -7.83 -0.39 6.46e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg13206674 chr6:150067644 NUP43 0.59 9.24 0.45 2.87e-18 Lung cancer; LUSC cis rs4343996 0.754 rs4719883 chr7:3350741 T/A cg21248987 chr7:3385318 SDK1 -0.36 -6.24 -0.32 1.33e-9 Motion sickness; LUSC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg12615879 chr12:58013172 SLC26A10 -0.28 -6.0 -0.31 5.24e-9 Multiple sclerosis; LUSC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg11189052 chr15:85197271 WDR73 0.47 5.65 0.3 3.44e-8 Schizophrenia; LUSC cis rs2637266 1.000 rs7897015 chr10:78366566 G/C cg18941641 chr10:78392320 NA 0.39 7.22 0.37 3.61e-12 Pulmonary function; LUSC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg20243544 chr17:37824526 PNMT 0.47 5.8 0.3 1.53e-8 Glomerular filtration rate (creatinine); LUSC cis rs7968679 1 rs7968679 chr12:9313304 A/G cg26114124 chr12:9217669 LOC144571 -0.38 -6.97 -0.36 1.66e-11 Myopia; LUSC cis rs12997796 0.556 rs12477737 chr2:86930966 G/T cg25203885 chr2:87302643 LOC285074 -0.74 -8.05 -0.4 1.51e-14 Schizophrenia; LUSC cis rs12137294 0.866 rs896318 chr1:205205784 A/G cg21643547 chr1:205240462 TMCC2 -0.36 -6.46 -0.33 3.74e-10 Red cell distribution width; LUSC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg20406979 chr6:167373233 NA -0.26 -5.91 -0.31 8.42e-9 Crohn's disease; LUSC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg16405210 chr4:1374714 KIAA1530 -0.53 -8.35 -0.42 1.89e-15 Obesity-related traits; LUSC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg08677398 chr8:58056175 NA 0.54 6.65 0.34 1.23e-10 Developmental language disorder (linguistic errors); LUSC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg11752832 chr7:134001865 SLC35B4 -0.61 -9.49 -0.46 4.61e-19 Mean platelet volume; LUSC trans rs6951245 0.529 rs76001997 chr7:1152615 C/T cg13565492 chr6:43139072 SRF -0.73 -10.92 -0.51 5.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2281845 0.507 rs1536127 chr1:201086894 C/A cg06714761 chr1:201096289 NA 0.42 7.66 0.39 2.05e-13 Permanent tooth development; LUSC cis rs12940923 1.000 rs34770605 chr17:56376206 C/T cg19466818 chr17:56409534 MIR142 -0.38 -6.63 -0.34 1.39e-10 Circulating myeloperoxidase levels (plasma); LUSC cis rs10193935 0.901 rs10175378 chr2:42456267 A/C cg27598129 chr2:42591480 NA -0.59 -7.84 -0.39 5.91e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg01802117 chr1:53393560 SCP2 0.39 6.36 0.33 6.52e-10 Monocyte count; LUSC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.1 0.36 7.58e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg23583168 chr7:148888333 NA -0.91 -17.45 -0.69 6.14e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs3087591 0.922 rs2341348 chr17:29534867 C/T cg24425628 chr17:29625626 OMG;NF1 0.58 8.32 0.41 2.31e-15 Hip circumference; LUSC trans rs3942852 0.955 rs1910364 chr11:48113232 A/G cg15704280 chr7:45808275 SEPT13 -0.54 -6.2 -0.32 1.67e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs8077577 0.895 rs62072465 chr17:18114494 C/G cg16794390 chr17:18148240 FLII 0.41 5.75 0.3 2.01e-8 Obesity-related traits; LUSC cis rs4474465 0.850 rs4579956 chr11:78232445 G/C cg27205649 chr11:78285834 NARS2 0.54 6.12 0.32 2.61e-9 Alzheimer's disease (survival time); LUSC cis rs7937682 0.889 rs487985 chr11:111517908 G/A cg09085632 chr11:111637200 PPP2R1B -1.11 -17.83 -0.7 1.92e-50 Primary sclerosing cholangitis; LUSC cis rs2289328 0.882 rs16970633 chr15:40642877 G/T cg13931752 chr15:40660718 DISP2 0.45 5.99 0.31 5.35e-9 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg06552810 chr11:31128660 NA 0.39 6.9 0.35 2.62e-11 Red blood cell count; LUSC cis rs870825 0.616 rs28636679 chr4:185627481 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.12 0.58 5.35e-32 Blood protein levels; LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 16.55 0.67 2.46e-45 Platelet count; LUSC cis rs853679 0.546 rs200977 chr6:27854301 T/C cg26587870 chr6:27730563 NA -0.65 -5.66 -0.3 3.31e-8 Depression; LUSC cis rs11018904 0.906 rs55685917 chr11:89964365 T/C cg26028595 chr11:89956573 CHORDC1 -0.51 -6.14 -0.32 2.39e-9 Intelligence (multi-trait analysis); LUSC trans rs4332037 0.539 rs55988458 chr7:2059761 G/A cg25206134 chr2:45395956 NA 0.62 7.23 0.37 3.24e-12 Bipolar disorder; LUSC cis rs868036 0.756 rs2241421 chr15:68082825 G/A cg05925327 chr15:68127851 NA -0.32 -5.75 -0.3 2.02e-8 Restless legs syndrome; LUSC cis rs8114671 0.742 rs6058161 chr20:33620026 C/T cg07148914 chr20:33460835 GGT7 -0.45 -6.67 -0.34 1.07e-10 Height; LUSC cis rs8060686 0.563 rs118005841 chr16:68157562 A/T cg09835421 chr16:68378352 PRMT7 -0.56 -6.07 -0.32 3.38e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs394563 0.591 rs237018 chr6:149743930 A/G cg03678062 chr6:149772716 ZC3H12D -0.3 -6.13 -0.32 2.42e-9 Dupuytren's disease; LUSC cis rs5758511 0.514 rs9607885 chr22:42578596 T/C cg00645731 chr22:42541494 CYP2D7P1 0.55 9.5 0.46 4.19e-19 Birth weight; LUSC cis rs7937682 0.632 rs10891294 chr11:111699224 C/T cg09085632 chr11:111637200 PPP2R1B 0.93 12.54 0.57 7.95e-30 Primary sclerosing cholangitis; LUSC cis rs12681288 0.550 rs12675410 chr8:957845 T/C cg15309053 chr8:964076 NA 0.42 8.66 0.43 2.11e-16 Schizophrenia; LUSC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg03060546 chr3:49711283 APEH 0.54 8.33 0.41 2.18e-15 Parkinson's disease; LUSC cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg07936489 chr17:37558343 FBXL20 -0.7 -9.78 -0.47 5e-20 Glomerular filtration rate (creatinine); LUSC cis rs1788820 0.917 rs1788785 chr18:21142340 T/C cg14672496 chr18:21087552 C18orf8 0.42 6.79 0.35 5.02e-11 Body mass index; LUSC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg24733560 chr20:60626293 TAF4 0.41 6.73 0.35 7.6e-11 Body mass index; LUSC cis rs6998277 1.000 rs4281092 chr8:103647956 A/G cg10187029 chr8:103597600 NA -0.62 -8.06 -0.4 1.36e-14 Migraine; LUSC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.69 12.1 0.55 3.42e-28 Personality dimensions; LUSC cis rs3771570 1.000 rs73002111 chr2:242277833 C/T cg21155796 chr2:242212141 HDLBP 0.63 6.86 0.35 3.32e-11 Prostate cancer; LUSC cis rs9463078 0.727 rs2396371 chr6:44946550 C/T cg25276700 chr6:44698697 NA -0.28 -5.88 -0.31 1.02e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2658782 0.789 rs2658776 chr11:93147927 A/G cg15737290 chr11:93063684 CCDC67 0.64 7.95 0.4 2.91e-14 Pulmonary function decline; LUSC cis rs2742234 0.541 rs4648313 chr10:43716739 G/A cg15436174 chr10:43711423 RASGEF1A 0.44 7.06 0.36 9.75e-12 Hirschsprung disease; LUSC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg11871910 chr12:69753446 YEATS4 0.84 15.2 0.64 5.09e-40 Blood protein levels; LUSC cis rs4605213 0.528 rs12951858 chr17:49328627 C/G cg22932220 chr17:49244634 NME2;NME1-NME2 -0.4 -6.46 -0.33 3.78e-10 Height; LUSC cis rs6087990 0.735 rs6058892 chr20:31388461 C/T cg13636640 chr20:31349939 DNMT3B 0.91 18.56 0.71 2.37e-53 Ulcerative colitis; LUSC cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg01475377 chr6:109611718 NA -0.46 -8.38 -0.42 1.5e-15 Reticulocyte fraction of red cells; LUSC cis rs10876993 0.680 rs2277322 chr12:58009202 T/C cg12615879 chr12:58013172 SLC26A10 -0.3 -6.62 -0.34 1.47e-10 Celiac disease or Rheumatoid arthritis; LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.21 0.52 5.47e-25 Prudent dietary pattern; LUSC cis rs854765 0.583 rs4925123 chr17:17784374 A/G cg09796270 chr17:17721594 SREBF1 -0.42 -7.16 -0.36 5.27e-12 Total body bone mineral density; LUSC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -10.59 -0.5 8.72e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7267979 0.649 rs2500406 chr20:25401862 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.73 -12.96 -0.58 2.19e-31 Liver enzyme levels (alkaline phosphatase); LUSC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg00343986 chr7:65444356 GUSB 0.47 7.02 0.36 1.23e-11 Aortic root size; LUSC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg00750074 chr16:89608354 SPG7 0.56 10.48 0.5 2.16e-22 Multiple myeloma (IgH translocation); LUSC cis rs6831256 0.583 rs10937929 chr4:3483037 C/T cg16415104 chr4:3496300 NA -0.4 -7.34 -0.37 1.6e-12 LDL cholesterol;Triglyceride levels;Triglycerides;Cholesterol, total; LUSC trans rs1864585 0.520 rs17718772 chr8:10648056 G/C cg26278703 chr11:58910052 FAM111A 0.54 6.05 0.31 3.95e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; LUSC cis rs1014246 0.848 rs10787718 chr10:118467648 A/G cg14919929 chr10:118506882 NA -0.44 -6.75 -0.35 6.4e-11 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs4776059 0.550 rs8032394 chr15:52868032 G/A cg25063058 chr15:52860530 ARPP19 0.53 6.45 0.33 3.82e-10 Schizophrenia; LUSC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg23093090 chr10:104574429 C10orf26 -0.45 -8.01 -0.4 1.9e-14 Arsenic metabolism; LUSC cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg18681998 chr4:17616180 MED28 0.78 13.81 0.6 1.26e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9341835 0.740 rs9294215 chr6:64151771 C/G cg03326410 chr6:64151739 NA -0.37 -6.13 -0.32 2.53e-9 Schizophrenia; LUSC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg16423285 chr20:60520624 NA -0.47 -5.87 -0.31 1.06e-8 Body mass index; LUSC cis rs16986825 0.570 rs5762879 chr22:29286180 C/T cg02153584 chr22:29168773 CCDC117 0.57 6.68 0.34 1.02e-10 Pancreatic cancer; LUSC cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg19628046 chr18:33552617 C18orf21 0.51 6.17 0.32 1.96e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs6516091 0.850 rs75701968 chr20:6049985 C/T cg25325723 chr20:6104886 FERMT1 -0.65 -7.0 -0.36 1.39e-11 Abdominal aortic aneurysm; LUSC cis rs4805272 0.512 rs765484 chr19:29344663 A/G cg04546413 chr19:29218101 NA 0.59 7.26 0.37 2.72e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs13392177 0.684 rs6720105 chr2:219080718 G/A cg00012203 chr2:219082015 ARPC2 -0.77 -13.07 -0.58 8.24e-32 Pyoderma gangrenosum in inflammatory bowel disease; LUSC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg06873352 chr17:61820015 STRADA 0.73 12.84 0.57 6.28e-31 Prudent dietary pattern; LUSC cis rs1994135 0.669 rs11052747 chr12:33697913 C/G cg06521331 chr12:34319734 NA -0.4 -5.89 -0.31 9.25e-9 Resting heart rate; LUSC trans rs12210905 0.925 rs72838236 chr6:26971202 C/T cg11837749 chr1:55047332 ACOT11 0.57 6.09 0.32 3.07e-9 Hip circumference adjusted for BMI; LUSC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg00484396 chr16:3507460 NAT15 -0.43 -6.91 -0.35 2.47e-11 Body mass index (adult); LUSC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg02376097 chr19:46275166 DMPK 0.4 7.0 0.36 1.42e-11 Coronary artery disease; LUSC trans rs77204473 0.744 rs17120293 chr11:116944846 A/G cg14717557 chr6:100895618 SIM1 -0.54 -6.41 -0.33 5.01e-10 Eosinophil counts;Sum eosinophil basophil counts; LUSC cis rs6977660 1.000 rs7812001 chr7:19803323 A/G cg05791153 chr7:19748676 TWISTNB -0.58 -6.63 -0.34 1.33e-10 Thyroid stimulating hormone; LUSC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg21724239 chr8:58056113 NA 0.85 9.05 0.44 1.18e-17 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.773 rs60466370 chr8:58171248 A/C cg22535103 chr8:58192502 C8orf71 -0.75 -9.55 -0.46 2.95e-19 Developmental language disorder (linguistic errors); LUSC cis rs4363385 0.818 rs1334849 chr1:153004652 A/G cg00922841 chr1:152955080 SPRR1A 0.33 5.79 0.3 1.59e-8 Inflammatory skin disease; LUSC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg05340658 chr4:99064831 C4orf37 0.66 11.3 0.53 2.82e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18099408 chr3:52552593 STAB1 -0.42 -7.3 -0.37 2.09e-12 Bipolar disorder; LUSC cis rs981844 1.000 rs2606342 chr4:154659980 C/A cg14289246 chr4:154710475 SFRP2 0.5 6.36 0.33 6.49e-10 Response to statins (LDL cholesterol change); LUSC cis rs6977660 1.000 rs13233821 chr7:19813637 A/C cg05791153 chr7:19748676 TWISTNB 0.56 6.26 0.32 1.17e-9 Thyroid stimulating hormone; LUSC cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg11266682 chr4:10021025 SLC2A9 0.55 10.06 0.48 5.64e-21 Bone mineral density; LUSC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg15782153 chr7:917662 C7orf20 0.43 6.65 0.34 1.22e-10 Perceived unattractiveness to mosquitoes; LUSC trans rs4295623 0.531 rs2898295 chr8:11595969 C/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.65 -0.39 2.18e-13 Morning vs. evening chronotype; LUSC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg10664184 chr19:17420304 DDA1 -0.46 -6.12 -0.32 2.65e-9 Systemic lupus erythematosus; LUSC cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg19628046 chr18:33552617 C18orf21 0.52 6.29 0.33 9.87e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs10791097 0.694 rs11222370 chr11:130744767 T/G cg12179176 chr11:130786555 SNX19 0.85 14.85 0.63 1.22e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs2718058 0.613 rs2718037 chr7:37777846 G/C cg15028436 chr7:37888078 TXNDC3 0.35 5.77 0.3 1.79e-8 Alzheimer's disease (late onset); LUSC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg15556689 chr8:8085844 FLJ10661 0.69 11.1 0.52 1.41e-24 Mood instability; LUSC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg20573242 chr4:122745356 CCNA2 0.64 9.03 0.44 1.36e-17 Type 2 diabetes; LUSC cis rs9747201 1.000 rs58119191 chr17:80155329 T/C cg17462356 chr17:80056334 FASN -0.46 -6.21 -0.32 1.53e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6500395 1.000 rs12934126 chr16:48705951 C/G cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg18305652 chr10:134549665 INPP5A 0.42 6.62 0.34 1.45e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.19 15.22 0.64 4.13e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7523273 0.606 rs1474742 chr1:207976666 A/C cg22525895 chr1:207977042 MIR29B2 0.37 5.91 0.31 8.5e-9 Schizophrenia; LUSC cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg25643088 chr3:52874325 TMEM110 -0.41 -5.95 -0.31 6.88e-9 Schizophrenia; LUSC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg27165867 chr14:105738592 BRF1 -0.56 -8.36 -0.42 1.7e-15 Mean platelet volume;Platelet distribution width; LUSC cis rs11630290 0.592 rs1912049 chr15:64155606 G/T cg12036633 chr15:63758958 NA 0.54 6.84 0.35 3.7e-11 Iris characteristics; LUSC cis rs453301 0.686 rs10217044 chr8:8894752 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.8 -0.39 8.14e-14 Joint mobility (Beighton score); LUSC cis rs35146811 0.735 rs1043915 chr7:99799845 T/A cg13334819 chr7:99746414 C7orf59 -0.5 -6.68 -0.34 1e-10 Coronary artery disease; LUSC cis rs2486288 0.656 rs12911861 chr15:45566718 T/C cg14582100 chr15:45693742 SPATA5L1 -0.42 -7.5 -0.38 5.66e-13 Glomerular filtration rate; LUSC cis rs61931739 0.500 rs7955933 chr12:34473608 A/G cg06521331 chr12:34319734 NA -0.42 -6.77 -0.35 5.87e-11 Morning vs. evening chronotype; LUSC cis rs12310956 0.515 rs115836245 chr12:33951369 T/C cg06521331 chr12:34319734 NA -0.45 -7.33 -0.37 1.79e-12 Morning vs. evening chronotype; LUSC cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg05340658 chr4:99064831 C4orf37 0.59 7.71 0.39 1.48e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg27286337 chr10:134555280 INPP5A 0.92 11.97 0.55 1.05e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7264396 0.690 rs2425180 chr20:34447160 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.53 -0.42 5.25e-16 Total cholesterol levels; LUSC cis rs9815354 0.812 rs73077386 chr3:41857652 A/G cg03022575 chr3:42003672 ULK4 0.83 8.73 0.43 1.28e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12629250 chr15:20149347 NA 0.48 6.42 0.33 4.59e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs939658 0.805 rs36068099 chr15:79438598 G/C cg17916960 chr15:79447300 NA -0.52 -10.38 -0.49 4.68e-22 Refractive error; LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg07157834 chr1:205819609 PM20D1 0.47 6.69 0.34 9.48e-11 Prostate-specific antigen levels; LUSC cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg02951883 chr7:2050386 MAD1L1 -0.37 -6.11 -0.32 2.7e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs6967385 0.519 rs7795828 chr7:12347689 C/T cg06484146 chr7:12443880 VWDE 0.52 7.76 0.39 1.07e-13 Response to taxane treatment (placlitaxel); LUSC cis rs7647973 0.593 rs7620848 chr3:49828021 G/C cg03060546 chr3:49711283 APEH -0.62 -7.37 -0.37 1.37e-12 Menarche (age at onset); LUSC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg14440974 chr22:39074834 NA -0.39 -6.5 -0.34 2.94e-10 Menopause (age at onset); LUSC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg14983838 chr19:29218262 NA 0.6 8.66 0.43 2.1e-16 Methadone dose in opioid dependence; LUSC cis rs6960043 0.818 rs2191348 chr7:15064255 G/T cg19272540 chr7:15055459 NA -0.32 -7.79 -0.39 8.77e-14 Type 2 diabetes; LUSC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -6.45 -0.33 3.84e-10 Total body bone mineral density; LUSC cis rs41271473 1.000 rs4641285 chr1:228878663 G/A cg10167378 chr1:228756711 NA 0.54 6.59 0.34 1.72e-10 Chronic lymphocytic leukemia; LUSC cis rs2274273 0.615 rs67008693 chr14:55702693 T/C cg04306507 chr14:55594613 LGALS3 0.48 9.5 0.46 4.1e-19 Protein biomarker; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21313137 chr20:44462302 SNX21 0.37 6.16 0.32 2.15e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg06873352 chr17:61820015 STRADA 0.69 12.61 0.57 4.56e-30 Prudent dietary pattern; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg08875078 chr22:50639485 SELO -0.46 -6.75 -0.35 6.56e-11 Electrocardiographic conduction measures; LUSC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg01616529 chr11:638424 DRD4 -0.35 -5.79 -0.3 1.65e-8 Systemic lupus erythematosus; LUSC cis rs4363385 0.791 rs10788855 chr1:153002359 A/T cg00922841 chr1:152955080 SPRR1A -0.41 -7.09 -0.36 8.12e-12 Inflammatory skin disease; LUSC cis rs4664308 0.875 rs2124969 chr2:160989486 T/C cg03641300 chr2:160917029 PLA2R1 -0.67 -11.58 -0.54 2.79e-26 Idiopathic membranous nephropathy; LUSC cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg01657329 chr11:68192670 LRP5 -0.49 -7.76 -0.39 1.07e-13 Total body bone mineral density; LUSC cis rs17255340 0.539 rs9449615 chr6:84089502 G/T cg08257003 chr6:84140564 ME1 0.35 8.75 0.43 1.1e-16 Platelet-derived growth factor BB levels; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03576123 chr11:487126 PTDSS2 -1.1 -11.52 -0.53 4.56e-26 Body mass index; LUSC cis rs3755132 0.929 rs59734551 chr2:15754125 G/A cg12888861 chr2:15731646 DDX1 0.51 7.3 0.37 2.1e-12 Wilms tumor; LUSC cis rs6580649 0.943 rs9651993 chr12:48404692 G/A cg24011408 chr12:48396354 COL2A1 0.51 6.84 0.35 3.71e-11 Lung cancer; LUSC cis rs10876993 0.928 rs10877001 chr12:58083077 T/C cg18357645 chr12:58087776 OS9 -0.55 -8.29 -0.41 2.71e-15 Celiac disease or Rheumatoid arthritis; LUSC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg26924012 chr15:45694286 SPATA5L1 1.14 19.88 0.74 1.4e-58 Homoarginine levels; LUSC cis rs12824058 0.798 rs7968728 chr12:130804696 T/A cg24838063 chr12:130822603 PIWIL1 0.67 10.45 0.5 2.57e-22 Menopause (age at onset); LUSC cis rs2766692 1.000 rs2766692 chr14:100684192 C/T cg14866419 chr14:100704911 YY1 0.46 5.89 0.31 9.28e-9 Electroencephalographic traits in alcoholism; LUSC cis rs7927771 0.524 rs4752798 chr11:47886364 T/C cg20307385 chr11:47447363 PSMC3 -0.47 -7.02 -0.36 1.24e-11 Subjective well-being; LUSC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg18230493 chr5:56204884 C5orf35 -0.89 -13.55 -0.6 1.19e-33 Initial pursuit acceleration; LUSC cis rs72627509 0.857 rs2227901 chr4:57798189 A/G cg26694713 chr4:57773883 REST -0.5 -6.07 -0.32 3.4e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs950169 0.922 rs62028133 chr15:84919375 A/C cg12863693 chr15:85201151 NMB 0.36 7.15 0.36 5.61e-12 Schizophrenia; LUSC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg23758822 chr17:41437982 NA 1.03 19.93 0.74 8.62e-59 Menopause (age at onset); LUSC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg15445000 chr17:37608096 MED1 -0.38 -6.5 -0.34 2.88e-10 Glomerular filtration rate (creatinine); LUSC cis rs7189233 0.911 rs8057808 chr16:53520613 G/A cg09728985 chr16:53543985 NA -0.38 -6.84 -0.35 3.73e-11 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.643 rs10902257 chr11:973577 T/C ch.11.42038R chr11:967971 AP2A2 0.43 6.37 0.33 6.19e-10 Alzheimer's disease (late onset); LUSC cis rs9341808 0.754 rs9352808 chr6:80997342 G/T cg08355045 chr6:80787529 NA 0.57 9.99 0.48 1e-20 Sitting height ratio; LUSC trans rs11098499 1.000 rs10029750 chr4:120172543 A/G cg25214090 chr10:38739885 LOC399744 0.46 6.81 0.35 4.64e-11 Corneal astigmatism; LUSC cis rs17270561 0.666 rs4712971 chr6:25771900 T/C cg16482183 chr6:26056742 HIST1H1C 0.6 8.21 0.41 4.76e-15 Iron status biomarkers; LUSC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg12016809 chr21:47604291 C21orf56 -0.44 -6.61 -0.34 1.53e-10 Testicular germ cell tumor; LUSC cis rs2239547 0.603 rs6805298 chr3:53096552 A/G cg18404041 chr3:52824283 ITIH1 0.53 9.21 0.45 3.64e-18 Schizophrenia; LUSC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg05585544 chr11:47624801 NA -0.4 -6.96 -0.36 1.81e-11 Subjective well-being; LUSC cis rs6121246 0.529 rs750144 chr20:30179027 C/T cg18721089 chr20:30220636 NA 0.37 5.87 0.31 1.03e-8 Mean corpuscular hemoglobin; LUSC cis rs2273669 0.667 rs9688896 chr6:109364698 T/C cg05315195 chr6:109294784 ARMC2 -0.54 -5.89 -0.31 9.41e-9 Prostate cancer; LUSC cis rs6060960 0.537 rs6087787 chr20:30452089 G/A cg06102403 chr20:30458708 TTLL9;DUSP15 0.46 5.68 0.3 2.95e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs3087591 0.708 rs7502834 chr17:29689430 G/A cg24425628 chr17:29625626 OMG;NF1 0.49 7.18 0.37 4.53e-12 Hip circumference; LUSC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.84 -0.3 1.22e-8 Platelet count; LUSC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.49 6.97 0.36 1.74e-11 Osteoporosis; LUSC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11644478 chr21:40555479 PSMG1 0.89 16.14 0.66 1.02e-43 Cognitive function; LUSC cis rs11098499 0.722 rs1814814 chr4:120258124 C/G cg24375607 chr4:120327624 NA 0.68 10.98 0.52 3.59e-24 Corneal astigmatism; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg13436085 chr3:183904316 ABCF3 0.38 6.36 0.33 6.52e-10 Triglycerides; LUSC cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg00071950 chr4:10020882 SLC2A9 -0.52 -8.73 -0.43 1.21e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg22532475 chr10:104410764 TRIM8 -0.28 -5.97 -0.31 6.03e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg19626725 chr5:178986131 RUFY1 -0.58 -10.88 -0.51 8.65e-24 Lung cancer; LUSC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.63 11.24 0.52 4.35e-25 Menopause (age at onset); LUSC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg17340268 chr14:105411764 AHNAK2 -0.38 -6.07 -0.32 3.41e-9 Rheumatoid arthritis; LUSC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg23791538 chr6:167370224 RNASET2 -0.42 -6.76 -0.35 6.11e-11 Crohn's disease; LUSC cis rs7605827 0.964 rs6733847 chr2:15564930 G/A cg19274914 chr2:15703543 NA 0.47 8.97 0.44 2.17e-17 Educational attainment (years of education); LUSC cis rs10779751 0.770 rs6701524 chr1:11198502 A/G cg08854313 chr1:11322531 MTOR -0.83 -12.7 -0.57 1.98e-30 Body mass index; LUSC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg14092988 chr3:52407081 DNAH1 0.33 6.28 0.33 1.04e-9 Bipolar disorder; LUSC cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg00071950 chr4:10020882 SLC2A9 0.62 10.66 0.5 5e-23 Bone mineral density; LUSC cis rs7824557 0.583 rs4448232 chr8:11231354 G/T cg21775007 chr8:11205619 TDH 0.71 11.26 0.52 3.73e-25 Retinal vascular caliber; LUSC cis rs17685 0.753 rs6465000 chr7:75787417 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.51 -7.74 -0.39 1.2e-13 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs11711311 0.712 rs6795099 chr3:113338782 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -6.07 -0.32 3.54e-9 IgG glycosylation; LUSC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg13628971 chr7:2884303 GNA12 -0.4 -6.16 -0.32 2.14e-9 Height; LUSC trans rs561341 0.609 rs11658984 chr17:30186612 C/T cg20587970 chr11:113659929 NA 0.81 9.8 0.47 4.41e-20 Hip circumference adjusted for BMI; LUSC cis rs3845702 0.736 rs3843323 chr2:180856459 T/C cg01881094 chr2:180872142 CWC22 -1.04 -12.28 -0.56 7.53e-29 Schizophrenia; LUSC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg25204440 chr1:209979598 IRF6 0.51 6.82 0.35 4.34e-11 Cleft lip with or without cleft palate; LUSC cis rs738322 0.935 rs4384 chr22:38572440 G/C cg25457927 chr22:38595422 NA -0.46 -9.83 -0.47 3.48e-20 Cutaneous nevi; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16303686 chr3:132136102 DNAJC13 -0.43 -6.47 -0.33 3.56e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs11098499 0.863 rs13149407 chr4:120437825 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.5 6.66 0.34 1.15e-10 Corneal astigmatism; LUSC cis rs9486719 1.000 rs12208884 chr6:96885572 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.0 -0.36 1.42e-11 Total body bone mineral density; LUSC cis rs77633900 0.772 rs284907 chr15:76741569 A/G cg21673338 chr15:77095150 SCAPER -0.7 -6.15 -0.32 2.19e-9 Non-glioblastoma glioma;Glioma; LUSC cis rs992157 1.000 rs4791 chr2:219138940 C/T cg00012203 chr2:219082015 ARPC2 0.82 14.08 0.61 1.18e-35 Colorectal cancer; LUSC cis rs4243830 0.737 rs11122083 chr1:6593532 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.83 -9.83 -0.47 3.36e-20 Body mass index; LUSC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg20295408 chr7:1910781 MAD1L1 -0.45 -6.28 -0.33 1.03e-9 Schizophrenia; LUSC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg04518342 chr5:131593106 PDLIM4 -0.35 -6.48 -0.33 3.33e-10 Blood metabolite levels; LUSC cis rs11971779 0.680 rs12154842 chr7:139078484 A/G cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg05535760 chr7:792225 HEATR2 0.77 9.24 0.45 2.91e-18 Cerebrospinal P-tau181p levels; LUSC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg08677398 chr8:58056175 NA 0.53 6.45 0.33 3.88e-10 Developmental language disorder (linguistic errors); LUSC cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.33 -0.37 1.77e-12 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs9462027 0.606 rs2744959 chr6:34616654 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.97 -0.31 6.1e-9 Systemic lupus erythematosus; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg19640263 chr11:62414186 GANAB -0.5 -6.5 -0.34 2.93e-10 Bipolar disorder and schizophrenia; LUSC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg10295955 chr4:187884368 NA -1.08 -25.56 -0.81 1.33e-80 Lobe attachment (rater-scored or self-reported); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09325506 chr2:243030735 LOC728323 0.41 5.98 0.31 5.76e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg02380750 chr20:61661411 NA 0.33 5.67 0.3 3.02e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.69 8.61 0.43 2.95e-16 LDL cholesterol;Cholesterol, total; LUSC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg17971929 chr21:40555470 PSMG1 0.77 12.86 0.58 4.88e-31 Cognitive function; LUSC cis rs7267979 0.565 rs6076364 chr20:25556801 T/C cg03522245 chr20:25566470 NINL -0.39 -6.0 -0.31 5.18e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7954584 0.635 rs7137218 chr12:122342877 G/T cg13699009 chr12:122356056 WDR66 0.48 7.55 0.38 4.24e-13 Mean corpuscular volume; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg11060661 chr22:24314208 DDT;DDTL 0.5 8.23 0.41 4.31e-15 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs4561483 0.603 rs11075033 chr16:12006338 C/T cg08843971 chr16:11963173 GSPT1 0.42 6.45 0.33 3.95e-10 Testicular germ cell tumor; LUSC cis rs7106204 0.620 rs16912295 chr11:24260162 T/C ch.11.24196551F chr11:24239977 NA 0.73 6.22 0.32 1.49e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2073300 1.000 rs34449811 chr20:23443771 T/C cg12062639 chr20:23401060 NAPB 0.78 6.02 0.31 4.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg09365446 chr1:150670422 GOLPH3L 0.52 7.88 0.4 4.74e-14 Tonsillectomy; LUSC cis rs8013055 0.846 rs8003942 chr14:105971670 A/G cg19700328 chr14:106028568 NA -0.41 -6.94 -0.36 1.99e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC trans rs1941687 0.527 rs1493914 chr18:31362327 C/T cg13755796 chr4:20253514 NA -0.41 -6.43 -0.33 4.42e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs709400 0.633 rs3783395 chr14:103895020 T/C cg24130564 chr14:104152367 KLC1 -0.43 -6.08 -0.32 3.33e-9 Body mass index; LUSC cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs737008 0.960 rs34764020 chr16:11378359 C/T cg00044050 chr16:11439710 C16orf75 -0.53 -8.13 -0.41 8.61e-15 Obesity-related traits; LUSC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg00579200 chr11:133705235 NA -0.41 -5.86 -0.31 1.14e-8 Childhood ear infection; LUSC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg13298116 chr11:62369859 EML3;MTA2 0.54 8.11 0.41 1.01e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); LUSC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg17211192 chr8:82754475 SNX16 -0.78 -10.66 -0.5 4.89e-23 Diastolic blood pressure; LUSC cis rs7592578 0.766 rs62182865 chr2:191434180 T/C cg10560079 chr2:191398806 TMEM194B -0.73 -8.49 -0.42 6.66e-16 Diastolic blood pressure; LUSC cis rs6964587 1.000 rs6970277 chr7:91680655 T/C cg17063962 chr7:91808500 NA 0.57 8.69 0.43 1.66e-16 Breast cancer; LUSC cis rs34779708 0.897 rs7897827 chr10:35386237 C/T cg04310649 chr10:35416472 CREM -0.44 -6.85 -0.35 3.54e-11 Inflammatory bowel disease;Crohn's disease; LUSC cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg23711669 chr6:146136114 FBXO30 0.87 15.58 0.65 1.61e-41 Lobe attachment (rater-scored or self-reported); LUSC trans rs4718428 0.705 rs4717328 chr7:66352665 T/C cg18876405 chr7:65276391 NA 0.49 6.66 0.34 1.14e-10 Corneal structure; LUSC cis rs6964587 0.869 rs10256780 chr7:91527176 T/A cg17063962 chr7:91808500 NA -0.53 -8.09 -0.4 1.12e-14 Breast cancer; LUSC cis rs62400317 0.826 rs12205642 chr6:45331765 T/C cg20913747 chr6:44695427 NA -0.48 -7.8 -0.39 7.82e-14 Total body bone mineral density; LUSC cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg03060546 chr3:49711283 APEH 0.69 10.1 0.48 4.05e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.27 -0.52 3.43e-25 Mean corpuscular volume; LUSC cis rs6500395 1.000 rs1120276 chr16:48598517 C/G cg04672837 chr16:48644449 N4BP1 0.43 6.47 0.33 3.44e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4595586 0.545 rs7486598 chr12:39371159 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.87 0.31 1.06e-8 Morning vs. evening chronotype; LUSC cis rs10743315 0.557 rs80051304 chr12:19286086 G/A cg02471346 chr12:19282374 PLEKHA5 0.94 6.82 0.35 4.25e-11 Gut microbiota (bacterial taxa); LUSC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg17554472 chr22:41940697 POLR3H -0.46 -5.68 -0.3 2.89e-8 Vitiligo; LUSC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg11366901 chr6:160182831 ACAT2 0.84 11.7 0.54 9.54e-27 Age-related macular degeneration (geographic atrophy); LUSC trans rs7824557 0.583 rs2263511 chr8:11233318 A/C cg06636001 chr8:8085503 FLJ10661 -0.54 -8.13 -0.41 8.27e-15 Retinal vascular caliber; LUSC cis rs9987353 0.566 rs6998368 chr8:9070288 G/C cg06636001 chr8:8085503 FLJ10661 -0.47 -6.59 -0.34 1.67e-10 Recombination measurement; LUSC cis rs7927592 0.913 rs7127948 chr11:68363062 G/A cg16797656 chr11:68205561 LRP5 0.38 6.21 0.32 1.58e-9 Total body bone mineral density; LUSC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg13607699 chr17:42295918 UBTF 0.75 13.86 0.6 8.11e-35 Red cell distribution width;Reticulocyte count; LUSC cis rs7582720 1.000 rs78907692 chr2:203932176 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.65 0.43 2.2e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC trans rs7618501 0.573 rs7634917 chr3:50049299 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.48 -0.46 4.78e-19 Intelligence (multi-trait analysis); LUSC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.85 0.3 1.2e-8 Tonsillectomy; LUSC cis rs7819412 0.745 rs2898260 chr8:10939490 G/T cg21775007 chr8:11205619 TDH -0.47 -6.82 -0.35 4.37e-11 Triglycerides; LUSC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg07701084 chr6:150067640 NUP43 0.54 8.02 0.4 1.82e-14 Lung cancer; LUSC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.96 -0.36 1.83e-11 Lung cancer; LUSC cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg13057898 chr1:3703894 LRRC47 0.52 8.86 0.44 4.96e-17 Red cell distribution width; LUSC cis rs6121246 0.529 rs6120862 chr20:30199459 T/C cg21427119 chr20:30132790 HM13 -0.44 -6.29 -0.33 9.94e-10 Mean corpuscular hemoglobin; LUSC cis rs79387448 0.745 rs76746266 chr2:103124920 C/T cg09003973 chr2:102972529 NA 0.86 8.52 0.42 5.6e-16 Gut microbiota (bacterial taxa); LUSC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg04414720 chr1:150670196 GOLPH3L 0.52 8.25 0.41 3.79e-15 Melanoma; LUSC cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg22920501 chr2:26401640 FAM59B 0.84 12.04 0.55 5.84e-28 Mean corpuscular hemoglobin; LUSC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg19046167 chr17:80928561 B3GNTL1 -0.45 -6.66 -0.34 1.1e-10 Breast cancer; LUSC cis rs2425143 0.730 rs6060626 chr20:34415073 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -5.9 -0.31 8.99e-9 Blood protein levels; LUSC cis rs9326248 0.581 rs7106437 chr11:116992076 T/C cg11861562 chr11:117069780 TAGLN 0.37 7.18 0.37 4.44e-12 Blood protein levels; LUSC cis rs2289583 0.642 rs55798479 chr15:75392210 C/T cg14664628 chr15:75095509 CSK 0.41 5.83 0.3 1.3e-8 Systemic lupus erythematosus; LUSC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg06873352 chr17:61820015 STRADA 0.73 13.02 0.58 1.27e-31 Prudent dietary pattern; LUSC cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg09479241 chr17:27052676 TLCD1 0.43 5.84 0.3 1.23e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg13939156 chr17:80058883 NA 0.33 6.48 0.33 3.32e-10 Life satisfaction; LUSC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg08280861 chr8:58055591 NA 0.56 5.98 0.31 5.87e-9 Developmental language disorder (linguistic errors); LUSC cis rs2354432 1.000 rs10900325 chr1:146692174 C/T cg25205988 chr1:146714368 CHD1L -1.02 -12.08 -0.55 4.03e-28 Mitochondrial DNA levels; LUSC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg01579765 chr21:45077557 HSF2BP -0.52 -10.92 -0.51 6.1e-24 Mean corpuscular volume; LUSC cis rs829883 0.738 rs249854 chr12:98862772 G/A cg25150519 chr12:98850993 NA 0.8 13.66 0.6 4.68e-34 Colorectal adenoma (advanced); LUSC cis rs11190604 1.000 rs2295772 chr10:102265183 G/A cg07080220 chr10:102295463 HIF1AN 0.68 9.04 0.44 1.34e-17 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10191773 0.589 rs72831638 chr2:112949212 C/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.51 -5.82 -0.3 1.41e-8 Yeast infection; LUSC cis rs11676348 0.729 rs13013361 chr2:218947515 A/T cg00012203 chr2:219082015 ARPC2 -0.52 -8.29 -0.41 2.79e-15 Ulcerative colitis; LUSC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg14664628 chr15:75095509 CSK -0.56 -8.43 -0.42 1.07e-15 Breast cancer; LUSC trans rs76513454 0.730 rs17571465 chr1:218890658 A/T cg22737241 chr10:557605 DIP2C -0.69 -6.17 -0.32 2e-9 Red blood cell density in sickle cell anemia; LUSC cis rs3008870 1.000 rs3008870 chr1:67418027 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 15.36 0.64 1.18e-40 Lymphocyte percentage of white cells; LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs151234 0.676 rs508022 chr16:28573963 C/T cg01378222 chr16:28622494 SULT1A1 -0.62 -8.34 -0.42 1.91e-15 Platelet distribution width; LUSC cis rs9921338 0.886 rs4780363 chr16:11415891 C/T cg00044050 chr16:11439710 C16orf75 0.48 6.47 0.33 3.57e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg00310523 chr12:86230176 RASSF9 -0.47 -8.97 -0.44 2.22e-17 Major depressive disorder; LUSC trans rs11264799 0.669 rs12082378 chr1:157634567 C/A cg25498969 chr3:136062740 STAG1 -0.24 -6.25 -0.32 1.23e-9 IgA nephropathy; LUSC trans rs6502050 0.835 rs3935403 chr17:80114145 C/T cg07393940 chr7:158741817 NA 0.36 6.51 0.34 2.79e-10 Life satisfaction; LUSC cis rs861020 0.563 rs35898529 chr1:210053096 G/A cg05527609 chr1:210001259 C1orf107 -0.89 -11.78 -0.54 5.1e-27 Orofacial clefts; LUSC cis rs4144743 1.000 rs2317385 chr17:45329682 G/A cg18085866 chr17:45331354 ITGB3 -0.74 -7.72 -0.39 1.38e-13 Body mass index; LUSC cis rs9807989 0.765 rs9807962 chr2:102971664 A/G cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.67e-9 Asthma; LUSC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.47 6.06 0.31 3.66e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1348850 0.561 rs4893956 chr2:178373452 C/T cg22681709 chr2:178499509 PDE11A -0.47 -6.88 -0.35 2.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg06008330 chr7:65541103 ASL -0.4 -6.23 -0.32 1.43e-9 Aortic root size; LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg05165339 chr4:1420672 NA 0.28 6.37 0.33 6.16e-10 Obesity-related traits; LUSC cis rs11608355 0.521 rs7972346 chr12:109808771 C/G cg19025524 chr12:109796872 NA 0.42 7.8 0.39 8.17e-14 Neuroticism; LUSC trans rs11992162 0.621 rs13268810 chr8:11797430 A/T cg27411982 chr8:10470053 RP1L1 0.42 6.33 0.33 7.88e-10 Monocyte count; LUSC cis rs9326248 0.539 rs518181 chr11:116772787 C/A cg10130564 chr11:117069849 TAGLN 0.31 5.78 0.3 1.71e-8 Blood protein levels; LUSC cis rs1003719 0.788 rs9981226 chr21:38452127 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.71 11.61 0.54 2.1e-26 Eye color traits; LUSC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg26335602 chr6:28129616 ZNF389 0.44 5.97 0.31 5.91e-9 Depression; LUSC cis rs8078723 1.000 rs1042658 chr17:38173902 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.9 -0.35 2.6e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.91 0.31 8.5e-9 Rheumatoid arthritis; LUSC cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -8.04 -0.4 1.57e-14 Lymphocyte counts; LUSC trans rs6502050 0.799 rs9911129 chr17:80087819 C/T cg07393940 chr7:158741817 NA 0.38 6.74 0.35 6.87e-11 Life satisfaction; LUSC cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.09 -0.36 8.21e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs16937 0.662 rs12137294 chr1:205182872 A/C cg21643547 chr1:205240462 TMCC2 -0.36 -6.42 -0.33 4.72e-10 Schizophrenia; LUSC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg02018176 chr4:1364513 KIAA1530 0.52 8.83 0.43 6.21e-17 Obesity-related traits; LUSC cis rs6906287 0.647 rs34479834 chr6:118826244 T/A cg21191810 chr6:118973309 C6orf204 0.33 6.03 0.31 4.44e-9 Electrocardiographic conduction measures; LUSC cis rs78456975 1.000 rs10208340 chr2:1563100 G/A cg01028140 chr2:1542097 TPO -0.62 -8.38 -0.42 1.47e-15 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.73 -0.3 2.22e-8 Total body bone mineral density; LUSC cis rs11190604 0.806 rs11190510 chr10:102157175 G/A cg07080220 chr10:102295463 HIF1AN 0.59 7.72 0.39 1.36e-13 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg22963979 chr7:1858916 MAD1L1 -0.5 -7.7 -0.39 1.53e-13 Bipolar disorder and schizophrenia; LUSC cis rs9837602 1.000 rs9878931 chr3:99712634 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.41 -5.89 -0.31 9.26e-9 Breast cancer; LUSC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg12863693 chr15:85201151 NMB 0.35 6.84 0.35 3.79e-11 Schizophrenia; LUSC cis rs4343996 0.558 rs1554500 chr7:3415864 T/C cg21248987 chr7:3385318 SDK1 0.36 6.11 0.32 2.8e-9 Motion sickness; LUSC trans rs7824557 0.628 rs58283816 chr8:11192551 G/C cg06636001 chr8:8085503 FLJ10661 0.44 6.47 0.33 3.57e-10 Retinal vascular caliber; LUSC cis rs477692 1.000 rs554792 chr10:131423181 A/G cg26102564 chr10:131424627 MGMT 0.39 6.16 0.32 2.05e-9 Response to temozolomide; LUSC trans rs561341 0.769 rs559228 chr17:30294527 T/C cg27661571 chr11:113659931 NA -0.67 -7.7 -0.39 1.56e-13 Hip circumference adjusted for BMI; LUSC cis rs4319547 0.656 rs4997380 chr12:122838956 A/G cg05707623 chr12:122985044 ZCCHC8 -0.58 -7.25 -0.37 2.99e-12 Body mass index; LUSC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg05368731 chr17:41323189 NBR1 0.93 15.95 0.66 5.58e-43 Menopause (age at onset); LUSC cis rs6933660 0.610 rs71549125 chr6:151770796 A/C cg14262678 chr6:151773367 RMND1;C6orf211 0.51 7.62 0.38 2.69e-13 Menarche (age at onset); LUSC cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg04450456 chr4:17643702 FAM184B 0.37 6.19 0.32 1.81e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs12122100 0.651 rs12129691 chr1:146554147 C/T cg03526459 chr1:146549940 NA -0.41 -6.55 -0.34 2.2e-10 HIV-1 control; LUSC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg17633681 chr16:88106987 BANP 0.53 10.09 0.48 4.58e-21 Menopause (age at onset); LUSC cis rs13089785 0.965 rs67028142 chr3:123635213 A/G cg02012769 chr3:123398346 MYLK 0.34 6.26 0.32 1.2e-9 Intelligence (multi-trait analysis); LUSC cis rs7917772 0.582 rs4919661 chr10:104358403 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.94 0.51 5.25e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs34330 0.562 rs11055023 chr12:12853197 A/G cg04607235 chr12:12878440 APOLD1 -0.56 -6.38 -0.33 5.81e-10 Systemic lupus erythematosus; LUSC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg07936489 chr17:37558343 FBXL20 0.72 10.11 0.48 3.92e-21 Glomerular filtration rate (creatinine); LUSC cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg08085267 chr17:45401833 C17orf57 0.54 8.83 0.44 6.01e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs2439831 1.000 rs2253708 chr15:43797273 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.84 8.71 0.43 1.41e-16 Lung cancer in ever smokers; LUSC cis rs12421382 0.659 rs1439518 chr11:109382921 T/G cg27471124 chr11:109292789 C11orf87 0.42 7.43 0.38 9.39e-13 Schizophrenia; LUSC cis rs4423214 1.000 rs4944959 chr11:71168234 C/T cg05163923 chr11:71159392 DHCR7 -0.71 -10.55 -0.5 1.2e-22 Vitamin D levels; LUSC cis rs10504229 0.953 rs114806125 chr8:58182416 C/T cg11062466 chr8:58055876 NA 0.42 5.66 0.3 3.32e-8 Developmental language disorder (linguistic errors); LUSC cis rs3540 0.553 rs12592611 chr15:91004093 C/T cg03599575 chr15:90893182 GABARAPL3 0.34 5.83 0.3 1.34e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6700896 0.931 rs4655582 chr1:66153363 C/G cg04111102 chr1:66153794 NA 0.33 7.19 0.37 4.18e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs911555 0.755 rs17841064 chr14:103900609 A/G cg12935359 chr14:103987150 CKB -0.65 -10.4 -0.49 3.86e-22 Intelligence (multi-trait analysis); LUSC cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg20821713 chr7:1055600 C7orf50 -0.38 -5.9 -0.31 9.1e-9 Longevity;Endometriosis; LUSC trans rs984440 0.621 rs1028777 chr8:139077206 G/T cg03334052 chr1:168888044 NA 0.42 6.54 0.34 2.35e-10 Obesity-related traits; LUSC cis rs11098499 0.697 rs11941899 chr4:120382758 C/A cg09307838 chr4:120376055 NA 0.77 11.09 0.52 1.49e-24 Corneal astigmatism; LUSC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg21724239 chr8:58056113 NA -0.56 -6.84 -0.35 3.78e-11 Developmental language disorder (linguistic errors); LUSC cis rs2120019 0.567 rs28844983 chr15:75178088 T/A cg09165964 chr15:75287851 SCAMP5 -0.97 -11.87 -0.54 2.38e-27 Blood trace element (Zn levels); LUSC cis rs7647973 0.626 rs9835157 chr3:49797769 G/A cg03060546 chr3:49711283 APEH -0.62 -7.37 -0.37 1.37e-12 Menarche (age at onset); LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg18132916 chr6:79620363 NA -0.38 -5.69 -0.3 2.83e-8 Intelligence (multi-trait analysis); LUSC cis rs1865760 0.622 rs9968910 chr6:26072095 A/C cg17042849 chr6:26104293 HIST1H4C -0.42 -5.88 -0.31 9.82e-9 Height; LUSC cis rs9549367 0.713 rs3024764 chr13:113824314 A/G cg00898013 chr13:113819073 PROZ -0.61 -9.0 -0.44 1.77e-17 Platelet distribution width; LUSC trans rs4811340 0.600 rs2143941 chr20:51179222 G/A cg15736553 chr3:11610338 VGLL4 -0.33 -5.95 -0.31 6.7e-9 Thyroid peroxidase antibody positivity; LUSC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg11764359 chr7:65958608 NA -0.68 -10.47 -0.5 2.3e-22 Aortic root size; LUSC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg03388025 chr16:89894329 SPIRE2 0.31 6.47 0.33 3.52e-10 Vitiligo; LUSC cis rs6840360 0.615 rs72728173 chr4:152469373 C/T cg22705602 chr4:152727874 NA -0.32 -6.47 -0.33 3.41e-10 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg08677398 chr8:58056175 NA 0.49 6.14 0.32 2.31e-9 Developmental language disorder (linguistic errors); LUSC trans rs9388451 0.839 rs3966775 chr6:126067655 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.61 -9.68 -0.47 1.1e-19 Brugada syndrome; LUSC cis rs34638657 0.797 rs11645045 chr16:82202137 G/A cg09439754 chr16:82129088 HSD17B2 -0.4 -6.57 -0.34 1.97e-10 Lung adenocarcinoma; LUSC cis rs11608355 1.000 rs7132057 chr12:109880279 A/C cg05360138 chr12:110035743 NA 0.45 6.19 0.32 1.74e-9 Neuroticism; LUSC cis rs1348850 0.958 rs10930800 chr2:178459669 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 5.86 0.31 1.14e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4660306 0.961 rs11211138 chr1:46015157 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.42 -6.35 -0.33 7.04e-10 Homocysteine levels; LUSC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg23601095 chr6:26197514 HIST1H3D 0.73 7.35 0.37 1.52e-12 Gout;Renal underexcretion gout; LUSC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg08736216 chr1:53307985 ZYG11A 0.29 6.03 0.31 4.36e-9 Monocyte count; LUSC cis rs2075371 0.611 rs12707154 chr7:134015832 C/T cg20476274 chr7:133979776 SLC35B4 0.8 13.33 0.59 8.64e-33 Mean platelet volume; LUSC cis rs9815354 0.680 rs10510730 chr3:41849013 C/G cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs6912958 0.781 rs2207146 chr6:88180641 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.51 -7.19 -0.37 4.22e-12 Monocyte percentage of white cells; LUSC cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg07424592 chr7:64974309 NA 0.69 6.1 0.32 2.98e-9 Diabetic kidney disease; LUSC cis rs3771570 1.000 rs62190370 chr2:242384194 C/G cg21155796 chr2:242212141 HDLBP 0.6 6.54 0.34 2.28e-10 Prostate cancer; LUSC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg24399712 chr22:39784796 NA -0.63 -11.5 -0.53 5.01e-26 Intelligence (multi-trait analysis); LUSC cis rs7914558 1.000 rs7077291 chr10:104945751 C/T cg15744005 chr10:104629667 AS3MT -0.27 -5.72 -0.3 2.34e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg15501526 chr10:2543763 NA 0.7 12.12 0.55 2.81e-28 Age-related hearing impairment; LUSC cis rs1577917 1.000 rs1337850 chr6:86729103 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -8.82 -0.43 6.68e-17 Response to antipsychotic treatment; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02889909 chr14:75760889 NA -0.52 -6.12 -0.32 2.69e-9 Bipolar disorder and schizophrenia; LUSC cis rs2486288 0.656 rs8024620 chr15:45574329 C/T cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.69 -0.39 1.62e-13 Glomerular filtration rate; LUSC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11890956 chr21:40555474 PSMG1 1.04 21.37 0.76 1.82e-64 Cognitive function; LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg11494091 chr17:61959527 GH2 0.64 13.34 0.59 7.84e-33 Prudent dietary pattern; LUSC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg23719950 chr11:63933701 MACROD1 -0.55 -7.62 -0.38 2.63e-13 Mean platelet volume; LUSC cis rs2235544 0.579 rs1537323 chr1:54482523 G/T cg25741118 chr1:54482237 LDLRAD1 0.33 7.64 0.39 2.27e-13 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; LUSC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7267979 1.000 rs2257809 chr20:25266476 C/T cg08601574 chr20:25228251 PYGB 0.43 6.6 0.34 1.59e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2275620 0.966 rs6583969 chr10:96826245 G/A cg09036531 chr10:96991505 NA -0.41 -5.84 -0.3 1.27e-8 Gout; LUSC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg26769984 chr7:1090371 C7orf50 0.72 10.1 0.48 4.03e-21 Bronchopulmonary dysplasia; LUSC cis rs12701220 0.817 rs7798459 chr7:1087965 C/T cg23978390 chr7:1156363 C7orf50 0.49 6.01 0.31 4.76e-9 Bronchopulmonary dysplasia; LUSC cis rs9640161 0.830 rs3735165 chr7:150068371 T/C cg10018233 chr7:150070692 REPIN1 0.46 9.33 0.45 1.55e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.1 0.41 1.05e-14 Prudent dietary pattern; LUSC cis rs2153904 0.793 rs1891091 chr1:205661418 A/G cg23034840 chr1:205782522 SLC41A1 0.6 5.71 0.3 2.47e-8 Prostate-specific antigen levels; LUSC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg15445000 chr17:37608096 MED1 0.38 6.71 0.34 8.31e-11 Glomerular filtration rate (creatinine); LUSC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -7.61 -0.38 2.91e-13 Developmental language disorder (linguistic errors); LUSC cis rs7927592 0.913 rs7106339 chr11:68240241 C/T cg16797656 chr11:68205561 LRP5 0.37 6.04 0.31 4.2e-9 Total body bone mineral density; LUSC cis rs4595586 0.545 rs12812750 chr12:39363258 C/T cg13010199 chr12:38710504 ALG10B 0.41 5.92 0.31 8.06e-9 Morning vs. evening chronotype; LUSC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg20243544 chr17:37824526 PNMT 0.48 6.73 0.35 7.42e-11 Asthma; LUSC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg08508325 chr11:3079039 CARS -0.48 -11.12 -0.52 1.16e-24 Type 2 diabetes; LUSC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg23625390 chr15:77176239 SCAPER 0.5 7.7 0.39 1.52e-13 Blood metabolite levels; LUSC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 6.53 0.34 2.51e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 7.21 0.37 3.73e-12 Mean platelet volume; LUSC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 8.1 0.41 1.04e-14 Bipolar disorder; LUSC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg21724239 chr8:58056113 NA 0.78 8.56 0.42 4.04e-16 Developmental language disorder (linguistic errors); LUSC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg10909506 chr17:38081995 ORMDL3 0.33 5.87 0.31 1.02e-8 Self-reported allergy; LUSC cis rs3764021 0.840 rs10743823 chr12:9881125 C/T cg20894963 chr12:9885564 CLECL1 0.33 6.68 0.34 9.93e-11 Type 1 diabetes; LUSC cis rs73198271 0.583 rs11781985 chr8:8589783 C/T cg01851573 chr8:8652454 MFHAS1 -0.38 -5.75 -0.3 2.03e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9359856 0.564 rs72915903 chr6:90420190 A/C cg13799429 chr6:90582589 CASP8AP2 -0.87 -8.89 -0.44 4e-17 Bipolar disorder; LUSC cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg03146154 chr1:46216737 IPP -0.55 -7.94 -0.4 3.11e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs77741769 0.529 rs3213572 chr12:121205078 A/G cg02419362 chr12:121203948 SPPL3 -0.46 -8.63 -0.43 2.57e-16 Mean corpuscular volume; LUSC cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg12011299 chr4:100065546 ADH4 0.68 9.38 0.46 1.05e-18 Alcohol dependence; LUSC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg03060546 chr3:49711283 APEH -0.69 -10.12 -0.48 3.6e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs897984 0.542 rs11865038 chr16:31095171 C/T cg02466173 chr16:30829666 NA -0.5 -9.55 -0.46 2.91e-19 Dementia with Lewy bodies; LUSC cis rs7084921 0.578 rs7474935 chr10:101875936 G/C cg11888571 chr10:102027403 CWF19L1 -0.46 -6.34 -0.33 7.53e-10 Bone mineral density; LUSC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg23711669 chr6:146136114 FBXO30 0.89 16.65 0.67 9.14e-46 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs1801251 0.711 rs778339 chr2:233739678 T/C cg25237894 chr2:233734115 C2orf82 -0.35 -6.52 -0.34 2.63e-10 Coronary artery disease; LUSC cis rs1107366 1.000 rs9874508 chr3:125902417 A/G cg20988073 chr3:125900093 ALDH1L1 0.3 6.06 0.31 3.59e-9 Metabolite levels; LUSC cis rs950027 0.620 rs1153855 chr15:45660758 C/G cg21132104 chr15:45694354 SPATA5L1 0.42 6.13 0.32 2.45e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg15445000 chr17:37608096 MED1 -0.39 -6.8 -0.35 4.94e-11 Glomerular filtration rate (creatinine); LUSC cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg00071950 chr4:10020882 SLC2A9 -0.59 -9.82 -0.47 3.61e-20 Bone mineral density; LUSC trans rs11039798 0.582 rs1304193 chr11:48688588 C/T cg15704280 chr7:45808275 SEPT13 0.73 8.29 0.41 2.88e-15 Axial length; LUSC cis rs8114671 0.839 rs2104084 chr20:33649217 G/C cg24642439 chr20:33292090 TP53INP2 -0.41 -5.86 -0.31 1.09e-8 Height; LUSC cis rs6840360 0.555 rs4554052 chr4:152726610 T/C cg22705602 chr4:152727874 NA 0.39 8.16 0.41 7.06e-15 Intelligence (multi-trait analysis); LUSC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg10909506 chr17:38081995 ORMDL3 0.34 6.09 0.32 3.12e-9 Self-reported allergy; LUSC cis rs4595586 0.525 rs7968566 chr12:39377200 C/T cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs7615952 0.611 rs2947646 chr3:125593602 C/T cg05084668 chr3:125655381 ALG1L 0.83 11.42 0.53 9.83e-26 Blood pressure (smoking interaction); LUSC cis rs4253772 0.550 rs11703564 chr22:46722194 G/A cg00784671 chr22:46762841 CELSR1 -0.49 -5.93 -0.31 7.55e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs7727544 0.582 rs3805683 chr5:131535125 T/G cg14196790 chr5:131705035 SLC22A5 0.45 7.57 0.38 3.68e-13 Blood metabolite levels; LUSC cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg13010199 chr12:38710504 ALG10B 0.61 9.58 0.46 2.34e-19 Drug-induced liver injury (flucloxacillin); LUSC cis rs8114671 0.967 rs2065979 chr20:33767690 T/C cg24642439 chr20:33292090 TP53INP2 0.4 5.84 0.3 1.22e-8 Height; LUSC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg15704280 chr7:45808275 SEPT13 -1.04 -18.06 -0.7 2.45e-51 Coronary artery disease; LUSC cis rs4332037 0.805 rs10278591 chr7:1921362 A/G cg23422044 chr7:1970798 MAD1L1 0.58 6.97 0.36 1.72e-11 Bipolar disorder; LUSC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg15017067 chr4:17643749 FAM184B 0.36 5.9 0.31 8.95e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9399135 0.967 rs59329760 chr6:135342437 G/A cg22676075 chr6:135203613 NA 0.46 7.32 0.37 1.86e-12 Red blood cell count; LUSC cis rs1577917 0.958 rs11755642 chr6:86450066 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.91 -0.35 2.44e-11 Response to antipsychotic treatment; LUSC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg23711669 chr6:146136114 FBXO30 -0.79 -14.11 -0.61 8.86e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg13866156 chr1:1669148 SLC35E2 -0.49 -7.92 -0.4 3.45e-14 Body mass index; LUSC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -11.08 -0.52 1.62e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg09044154 chr16:88155775 NA -0.57 -7.58 -0.38 3.43e-13 Menopause (age at onset); LUSC cis rs73195822 0.527 rs73194059 chr12:111221740 G/A cg12870014 chr12:110450643 ANKRD13A 0.68 7.14 0.36 5.98e-12 Itch intensity from mosquito bite; LUSC trans rs6952808 0.689 rs11771625 chr7:2050401 C/T cg04565464 chr8:145669602 NFKBIL2 0.37 6.05 0.31 3.8e-9 Bipolar disorder and schizophrenia; LUSC cis rs7677751 0.806 rs4864863 chr4:55100831 A/G cg17187183 chr4:55093834 PDGFRA 0.39 5.74 0.3 2.11e-8 Corneal astigmatism; LUSC cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14442939 chr10:27389572 ANKRD26 0.9 11.74 0.54 7.05e-27 Breast cancer; LUSC cis rs5769765 0.862 rs138870 chr22:50209737 C/T cg02269571 chr22:50332266 NA -0.54 -8.13 -0.41 8.33e-15 Schizophrenia; LUSC cis rs9325144 0.560 rs10785573 chr12:38654166 G/A cg13010199 chr12:38710504 ALG10B -0.51 -7.67 -0.39 1.87e-13 Morning vs. evening chronotype; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg21945992 chr3:48956913 ARIH2;C3orf71 -0.42 -6.27 -0.32 1.11e-9 Hepatitis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16515820 chr3:114866447 ZBTB20 0.43 6.54 0.34 2.36e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg25208724 chr1:156163844 SLC25A44 1.11 27.04 0.83 3.95e-86 Testicular germ cell tumor; LUSC cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg23788917 chr6:8435910 SLC35B3 0.51 7.56 0.38 3.86e-13 Motion sickness; LUSC cis rs425277 0.917 rs12410859 chr1:2038732 C/T cg24578937 chr1:2090814 PRKCZ 0.59 13.12 0.58 5.14e-32 Height; LUSC cis rs4730250 0.654 rs6947857 chr7:106787266 T/G cg02696742 chr7:106810147 HBP1 0.65 9.18 0.45 4.72e-18 Osteoarthritis; LUSC cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.24 0.37 3.04e-12 Gut microbiome composition (summer); LUSC trans rs6725041 0.805 rs6745249 chr2:213130571 A/G cg14430582 chr20:42295543 MYBL2 -0.43 -6.48 -0.33 3.28e-10 QT interval (ambient particulate matter interaction); LUSC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg11102782 chr19:18549136 ISYNA1 -0.34 -6.35 -0.33 6.85e-10 Breast cancer; LUSC cis rs936229 0.813 rs3784790 chr15:75081745 G/C cg14664628 chr15:75095509 CSK -1.01 -17.39 -0.69 1.06e-48 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg26380479 chr7:97908229 NA -0.28 -6.21 -0.32 1.56e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg26695010 chr11:65641043 EFEMP2 -0.46 -7.05 -0.36 1.04e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg04267008 chr7:1944627 MAD1L1 -0.49 -7.31 -0.37 1.97e-12 Bipolar disorder and schizophrenia; LUSC cis rs965469 1.000 rs2236092 chr20:3258188 G/C cg25506879 chr20:3388711 C20orf194 -0.53 -5.99 -0.31 5.48e-9 IFN-related cytopenia; LUSC trans rs11039798 0.841 rs10839174 chr11:48931185 G/A cg03929089 chr4:120376271 NA 0.72 6.86 0.35 3.37e-11 Axial length; LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg00684032 chr4:1343700 KIAA1530 0.36 6.06 0.31 3.69e-9 Obesity-related traits; LUSC cis rs10743315 0.557 rs17270134 chr12:19367047 G/A cg02471346 chr12:19282374 PLEKHA5 0.78 6.28 0.33 1.03e-9 Gut microbiota (bacterial taxa); LUSC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg24910161 chr17:38119198 GSDMA -0.28 -6.07 -0.32 3.49e-9 Asthma; LUSC cis rs6494488 0.500 rs72744723 chr15:65020727 C/A cg08069370 chr15:64387884 SNX1 -0.65 -5.92 -0.31 7.91e-9 Coronary artery disease; LUSC cis rs394563 0.602 rs409111 chr6:149766860 A/G cg03678062 chr6:149772716 ZC3H12D -0.33 -6.91 -0.35 2.53e-11 Dupuytren's disease; LUSC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg16680214 chr1:154839983 KCNN3 -0.51 -9.33 -0.45 1.56e-18 Prostate cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg10814329 chr22:46692864 CN5H6.4;GTSE1 0.66 6.0 0.31 5.17e-9 Cognitive performance; LUSC cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg12310025 chr6:25882481 NA -0.5 -9.07 -0.44 1.03e-17 Blood metabolite levels; LUSC cis rs4148883 0.689 rs1800760 chr4:100065626 A/T cg12011299 chr4:100065546 ADH4 0.49 7.94 0.4 3.06e-14 Alcohol dependence; LUSC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg03433033 chr1:76189801 ACADM 0.84 14.86 0.63 1.08e-38 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs10883723 0.518 rs10786679 chr10:104315667 C/T cg05855489 chr10:104503620 C10orf26 -0.65 -8.8 -0.43 7.74e-17 Allergic disease (asthma, hay fever or eczema); LUSC cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg00339695 chr16:24857497 SLC5A11 0.39 6.79 0.35 5.14e-11 Intelligence (multi-trait analysis); LUSC cis rs7746199 0.736 rs13193542 chr6:27702425 G/T cg26958806 chr6:27640298 NA 0.74 6.04 0.31 4.02e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs11098499 0.954 rs1022145 chr4:120230979 A/G cg24375607 chr4:120327624 NA 0.8 11.68 0.54 1.17e-26 Corneal astigmatism; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg17734135 chr20:3140367 UBOX5;FASTKD5 0.78 6.41 0.33 4.95e-10 Cognitive performance; LUSC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.5 7.69 0.39 1.72e-13 Lymphocyte counts; LUSC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg14196790 chr5:131705035 SLC22A5 0.41 7.0 0.36 1.45e-11 Blood metabolite levels; LUSC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg07217954 chr7:1067459 C7orf50 0.53 5.71 0.3 2.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs908922 0.523 rs4845786 chr1:152510144 A/G cg20991723 chr1:152506922 NA 0.5 9.44 0.46 6.55e-19 Hair morphology; LUSC trans rs633715 0.918 rs509325 chr1:177894591 A/C cg23454797 chr7:27183990 HOXA5 -0.51 -5.98 -0.31 5.79e-9 Body mass index (joint analysis main effects and physical activity interaction);Menarche (age at onset);Body mass index;Body mass index in physically inactive individuals;Obesity;Body mass index in physically active individuals;Waist circumference; LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg25767906 chr1:53392781 SCP2 -0.64 -12.65 -0.57 3.11e-30 Monocyte count; LUSC cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.84 -0.54 2.94e-27 Chronic sinus infection; LUSC cis rs17604090 0.793 rs66956566 chr7:29688702 A/G cg19413766 chr7:29689036 LOC646762 -0.56 -7.01 -0.36 1.36e-11 Facial emotion recognition;Facial emotion recognition (sad faces); LUSC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.91 -0.4 3.82e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.58 0.34 1.86e-10 Lung cancer; LUSC cis rs2279817 0.863 rs11203439 chr1:18026328 T/C cg21791023 chr1:18019539 ARHGEF10L 0.43 5.91 0.31 8.27e-9 Neuroticism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg10572969 chr11:13690188 FAR1 -0.4 -6.14 -0.32 2.31e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg17385448 chr1:15911702 AGMAT 0.38 6.49 0.33 3.03e-10 Systolic blood pressure; LUSC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg08219700 chr8:58056026 NA 0.67 7.53 0.38 4.78e-13 Developmental language disorder (linguistic errors); LUSC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg00701064 chr4:6280414 WFS1 0.59 14.2 0.61 3.93e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs45535039 1.000 rs1893032 chr11:119088883 G/A cg16724696 chr11:118992527 HINFP 0.47 5.78 0.3 1.68e-8 Plateletcrit; LUSC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg24562669 chr7:97807699 LMTK2 0.34 5.99 0.31 5.42e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg24829409 chr8:58192753 C8orf71 -0.61 -7.49 -0.38 6.09e-13 Developmental language disorder (linguistic errors); LUSC cis rs8078723 0.510 rs11655264 chr17:38138995 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.57 9.99 0.48 9.68e-21 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs1865760 1.000 rs7739966 chr6:25906040 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.87 0.35 3.11e-11 Height; LUSC cis rs9394152 0.845 rs769051 chr6:33473894 T/G cg13560919 chr6:33536144 NA 0.59 10.52 0.5 1.57e-22 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg02269571 chr22:50332266 NA -0.59 -8.83 -0.43 6.16e-17 Schizophrenia; LUSC cis rs2289583 0.573 rs12148555 chr15:75395475 C/T cg14664628 chr15:75095509 CSK 0.45 6.37 0.33 6.15e-10 Systemic lupus erythematosus; LUSC cis rs6844999 0.538 rs6852559 chr4:123591521 G/A cg10495464 chr4:123653540 BBS12;LOC729338 -0.49 -5.78 -0.3 1.73e-8 Cancer; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg02339392 chr6:28234615 ZNF187 0.33 6.13 0.32 2.51e-9 Tuberculosis; LUSC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.86 0.6 7.94e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs7582180 0.652 rs11123830 chr2:100974747 A/G cg08017756 chr2:100939284 LONRF2 -0.47 -8.71 -0.43 1.44e-16 Intelligence (multi-trait analysis); LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.13 0.32 2.46e-9 Menopause (age at onset); LUSC cis rs11229555 0.645 rs61903159 chr11:58184475 G/A cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg14440974 chr22:39074834 NA -0.35 -5.91 -0.31 8.52e-9 Menopause (age at onset); LUSC cis rs354225 0.584 rs7586311 chr2:54810762 A/G cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs5753618 0.509 rs5997913 chr22:31593959 C/A cg22777020 chr22:31556080 RNF185 -0.45 -5.74 -0.3 2.18e-8 Colorectal cancer; LUSC cis rs8072100 1.000 rs8065669 chr17:45724996 G/A cg08085267 chr17:45401833 C17orf57 -0.62 -10.41 -0.49 3.65e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg05165339 chr4:1420672 NA -0.29 -6.68 -0.34 9.95e-11 Longevity; LUSC cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg19418458 chr7:158789849 NA -0.59 -9.7 -0.47 9.33e-20 Facial morphology (factor 20); LUSC trans rs7824557 0.843 rs2572418 chr8:11113089 G/A cg15556689 chr8:8085844 FLJ10661 -0.53 -8.06 -0.4 1.39e-14 Retinal vascular caliber; LUSC cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg18681998 chr4:17616180 MED28 0.78 13.54 0.6 1.34e-33 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg21535247 chr6:8435926 SLC35B3 0.6 9.27 0.45 2.37e-18 Motion sickness; LUSC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg18512352 chr11:47633146 NA -0.46 -9.19 -0.45 4.42e-18 Subjective well-being; LUSC trans rs11992162 0.613 rs6998690 chr8:11798796 A/T cg15556689 chr8:8085844 FLJ10661 0.48 6.77 0.35 5.73e-11 Monocyte count; LUSC cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs6121246 0.909 rs6089070 chr20:30377773 A/G cg13852791 chr20:30311386 BCL2L1 -0.95 -12.31 -0.56 5.89e-29 Mean corpuscular hemoglobin; LUSC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg26338869 chr17:61819248 STRADA 0.4 5.77 0.3 1.81e-8 Prudent dietary pattern; LUSC trans rs1814175 0.904 rs1846289 chr11:49620253 G/A cg15704280 chr7:45808275 SEPT13 -1.08 -21.61 -0.76 2.15e-65 Height; LUSC cis rs12986413 0.967 rs1074047 chr19:2158748 A/G cg09261902 chr19:2140048 AP3D1 0.33 6.13 0.32 2.46e-9 Height; LUSC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg03289416 chr15:75166202 SCAMP2 0.45 7.04 0.36 1.13e-11 Breast cancer; LUSC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18404041 chr3:52824283 ITIH1 -0.52 -10.19 -0.49 2.09e-21 Bipolar disorder; LUSC cis rs709400 0.520 rs28583452 chr14:103938664 C/A cg10523860 chr14:103875565 MARK3 -0.38 -6.09 -0.32 3.1e-9 Body mass index; LUSC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg00944433 chr1:107599041 PRMT6 -0.38 -7.03 -0.36 1.14e-11 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg00277334 chr10:82204260 NA -0.95 -20.09 -0.74 2e-59 Post bronchodilator FEV1; LUSC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg22963979 chr7:1858916 MAD1L1 0.55 8.62 0.43 2.8e-16 Bipolar disorder and schizophrenia; LUSC cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs6456156 0.526 rs1854853 chr6:167533062 A/G cg07741184 chr6:167504864 NA -0.47 -8.64 -0.43 2.44e-16 Primary biliary cholangitis; LUSC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg22823121 chr1:150693482 HORMAD1 0.58 9.08 0.44 9.78e-18 Tonsillectomy; LUSC cis rs10100465 0.961 rs2202793 chr8:118633557 C/T cg09430518 chr8:118662568 NA -0.3 -5.78 -0.3 1.73e-8 Leprosy; LUSC cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg13047869 chr3:10149882 C3orf24 0.65 9.09 0.45 8.75e-18 Alzheimer's disease; LUSC trans rs62055045 0.528 rs57342394 chr16:71562859 G/A cg21834679 chr15:96891026 NA -0.39 -6.21 -0.32 1.59e-9 Schizophrenia; LUSC cis rs1670533 1.000 rs10084888 chr4:1053814 G/T cg27284194 chr4:1044797 NA 0.59 8.97 0.44 2.1e-17 Recombination rate (females); LUSC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg05855489 chr10:104503620 C10orf26 0.57 9.29 0.45 2.07e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.25 0.56 9.74e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs12579753 0.879 rs7958657 chr12:82135067 G/A cg07923666 chr12:49932857 KCNH3 -0.53 -6.56 -0.34 2.05e-10 Resting heart rate; LUSC cis rs9400467 0.508 rs61269242 chr6:111803059 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.67 -0.34 1.04e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg03676636 chr4:99064102 C4orf37 0.33 7.1 0.36 7.64e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25510282 chr3:156544081 LEKR1 -0.41 -6.0 -0.31 5.22e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs4714291 0.963 rs1721409 chr6:40112439 A/T cg02267698 chr19:7991119 CTXN1 0.53 7.4 0.38 1.09e-12 Strep throat; LUSC cis rs6545883 0.895 rs796597 chr2:61681060 A/G cg15711740 chr2:61764176 XPO1 -0.46 -6.91 -0.35 2.39e-11 Tuberculosis; LUSC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.79 0.39 8.49e-14 Lung function (FEV1/FVC); LUSC cis rs17270561 0.609 rs9379783 chr6:25725207 C/T cg17691542 chr6:26056736 HIST1H1C 0.57 8.02 0.4 1.8e-14 Iron status biomarkers; LUSC cis rs10435719 0.902 rs7014580 chr8:11803262 C/G cg21775007 chr8:11205619 TDH 0.46 6.59 0.34 1.76e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg27170947 chr2:26402098 FAM59B -0.71 -10.85 -0.51 1.04e-23 Gut microbiome composition (summer); LUSC trans rs7681440 0.904 rs28750169 chr4:90774303 A/G cg02113368 chr10:135107346 TUBGCP2 -0.33 -5.97 -0.31 6.19e-9 Dementia with Lewy bodies; LUSC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg16325326 chr1:53192061 ZYG11B -0.89 -16.56 -0.67 2.2e-45 Monocyte count; LUSC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg06637938 chr14:75390232 RPS6KL1 -0.49 -7.64 -0.39 2.31e-13 Height; LUSC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg06481639 chr22:41940642 POLR3H -0.46 -5.84 -0.3 1.22e-8 Vitiligo; LUSC cis rs62400317 0.518 rs1321080 chr6:45358323 G/T cg18551225 chr6:44695536 NA -0.43 -6.57 -0.34 1.92e-10 Total body bone mineral density; LUSC cis rs8060686 0.516 rs7197756 chr16:68275516 A/C cg05110241 chr16:68378359 PRMT7 -0.49 -6.18 -0.32 1.84e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs1003719 0.788 rs61701101 chr21:38450317 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.43 0.53 9.1e-26 Eye color traits; LUSC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg20476274 chr7:133979776 SLC35B4 0.87 17.0 0.68 4.02e-47 Mean platelet volume; LUSC cis rs7590255 1.000 rs13403092 chr2:37987680 C/T cg23497611 chr2:37985316 NA 0.44 6.42 0.33 4.68e-10 Nonsyndromic cleft lip with cleft palate; LUSC cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg24692254 chr21:30365293 RNF160 -0.54 -8.01 -0.4 1.87e-14 Dental caries; LUSC cis rs8114671 0.967 rs2069952 chr20:33763951 C/T cg24642439 chr20:33292090 TP53INP2 0.41 5.93 0.31 7.46e-9 Height; LUSC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg02415014 chr8:143852576 LYNX1 -0.29 -7.25 -0.37 2.9e-12 Urinary tract infection frequency; LUSC trans rs7937682 0.961 rs17113227 chr11:111620491 A/G cg18187862 chr3:45730750 SACM1L 0.61 7.62 0.38 2.65e-13 Primary sclerosing cholangitis; LUSC cis rs11958404 0.932 rs72816540 chr5:157414500 T/C cg05962755 chr5:157440814 NA 0.49 6.13 0.32 2.44e-9 IgG glycosylation; LUSC cis rs8044868 0.586 rs12917999 chr16:72089451 T/C cg16579770 chr16:72058938 DHODH 0.34 5.74 0.3 2.08e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; LUSC cis rs3008870 0.536 rs2208576 chr1:67513401 C/G cg08660285 chr1:67390436 MIER1;WDR78 -0.53 -7.85 -0.39 5.81e-14 Lymphocyte percentage of white cells; LUSC cis rs2274273 0.875 rs2075602 chr14:55609774 A/G cg04306507 chr14:55594613 LGALS3 0.58 13.35 0.59 6.92e-33 Protein biomarker; LUSC cis rs1728785 1.000 rs12918865 chr16:68566546 G/A cg02972257 chr16:68554789 NA -0.48 -6.21 -0.32 1.56e-9 Ulcerative colitis; LUSC cis rs4285028 0.747 rs1920299 chr3:121593769 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.74 10.12 0.48 3.63e-21 Multiple sclerosis; LUSC cis rs10791097 0.592 rs7116068 chr11:130732739 A/C cg12179176 chr11:130786555 SNX19 -0.83 -14.01 -0.61 2.09e-35 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg09184832 chr6:79620586 NA -0.44 -7.06 -0.36 9.88e-12 Intelligence (multi-trait analysis); LUSC cis rs1832871 0.711 rs9457300 chr6:158714609 G/C cg07165851 chr6:158734300 TULP4 0.5 7.66 0.39 2.05e-13 Height; LUSC cis rs6967385 0.934 rs3815532 chr7:12371459 C/G cg06484146 chr7:12443880 VWDE 0.4 5.84 0.3 1.21e-8 Response to taxane treatment (placlitaxel); LUSC cis rs10504229 0.834 rs7015674 chr8:58153166 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -7.92 -0.4 3.51e-14 Developmental language disorder (linguistic errors); LUSC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.54 7.64 0.39 2.26e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs854765 0.547 rs2955380 chr17:17944349 A/G cg24904631 chr17:17875305 TOM1L2;LRRC48 -0.39 -6.16 -0.32 2.09e-9 Total body bone mineral density; LUSC cis rs4665809 0.652 rs4665832 chr2:26404775 A/G cg26314531 chr2:26401878 FAM59B -0.7 -9.64 -0.47 1.4e-19 Gut microbiome composition (summer); LUSC cis rs11229555 0.598 rs12269888 chr11:58184336 T/C cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs314370 0.951 rs17884589 chr7:100493711 G/A cg08558340 chr7:100472263 SRRT 0.51 6.26 0.32 1.2e-9 Resting heart rate; LUSC cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg01579765 chr21:45077557 HSF2BP -0.55 -11.53 -0.53 3.94e-26 Mean corpuscular volume; LUSC cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg22467129 chr15:76604101 ETFA -0.39 -6.03 -0.31 4.33e-9 Blood metabolite levels; LUSC trans rs12310956 0.510 rs6488178 chr12:33885251 C/G cg13010199 chr12:38710504 ALG10B 0.45 6.92 0.35 2.25e-11 Morning vs. evening chronotype; LUSC cis rs12594515 1.000 rs56220882 chr15:45997075 C/G cg06207120 chr15:45996521 NA 0.39 5.89 0.31 9.46e-9 Waist circumference;Weight; LUSC cis rs6066835 1.000 rs6125439 chr20:47314634 G/A cg18078177 chr20:47281410 PREX1 0.73 6.18 0.32 1.82e-9 Multiple myeloma; LUSC cis rs4619890 0.528 rs28600706 chr4:7876410 T/C cg24250820 chr4:7887609 AFAP1 0.36 6.15 0.32 2.16e-9 Glaucoma (primary open-angle); LUSC cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg23711669 chr6:146136114 FBXO30 0.81 14.27 0.62 2.1e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs7607369 0.559 rs4674341 chr2:219659911 A/G cg02176678 chr2:219576539 TTLL4 -0.54 -9.62 -0.47 1.72e-19 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs72772090 0.539 rs72773917 chr5:96111302 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.75 -7.79 -0.39 8.5e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs757278 0.552 rs11764070 chr7:117312350 T/G cg10524701 chr7:117356490 CTTNBP2 0.4 5.69 0.3 2.72e-8 Response to methotrexate in juvenile idiopathic arthritis; LUSC cis rs73198271 0.628 rs11777908 chr8:8590437 C/T cg01851573 chr8:8652454 MFHAS1 0.46 5.77 0.3 1.83e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg09165964 chr15:75287851 SCAMP5 -1.01 -14.99 -0.63 3.29e-39 Blood trace element (Zn levels); LUSC cis rs11122272 0.735 rs2790897 chr1:231491712 C/A cg06096015 chr1:231504339 EGLN1 0.58 10.4 0.49 3.84e-22 Hemoglobin concentration; LUSC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg18850127 chr7:39170497 POU6F2 0.66 10.73 0.51 2.8e-23 IgG glycosylation; LUSC cis rs854765 0.663 rs4925120 chr17:17754633 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.76 -13.32 -0.59 9.64e-33 Total body bone mineral density; LUSC cis rs11676348 0.774 rs4672870 chr2:218941916 C/T cg00012203 chr2:219082015 ARPC2 -0.46 -6.92 -0.35 2.29e-11 Ulcerative colitis; LUSC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.13 -0.45 6.78e-18 Gut microbiome composition (summer); LUSC cis rs7903847 0.656 rs12412478 chr10:99134923 C/T cg08345082 chr10:99160200 RRP12 -0.32 -5.67 -0.3 3.15e-8 Granulocyte percentage of myeloid white cells; LUSC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg10909506 chr17:38081995 ORMDL3 0.35 6.29 0.33 9.89e-10 Self-reported allergy; LUSC cis rs7584330 0.554 rs1343768 chr2:238444881 G/A cg16989719 chr2:238392110 NA -0.41 -5.91 -0.31 8.32e-9 Prostate cancer; LUSC cis rs2231884 0.697 rs11227332 chr11:65623739 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.6 7.32 0.37 1.9e-12 Inflammatory bowel disease; LUSC trans rs2055729 0.885 rs13268133 chr8:9731470 C/T cg06636001 chr8:8085503 FLJ10661 0.5 6.93 0.35 2.21e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg05738196 chr6:26577821 NA 0.56 8.42 0.42 1.15e-15 Schizophrenia; LUSC cis rs4642101 0.561 rs9812144 chr3:12805910 G/A cg24848339 chr3:12840334 CAND2 0.33 6.48 0.33 3.21e-10 QRS complex (12-leadsum); LUSC trans rs61931739 0.517 rs860950 chr12:34104376 C/G cg13010199 chr12:38710504 ALG10B 0.54 8.05 0.4 1.48e-14 Morning vs. evening chronotype; LUSC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg16339924 chr4:17578868 LAP3 0.64 10.13 0.48 3.18e-21 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6502050 0.871 rs6502054 chr17:80066715 G/A cg13939156 chr17:80058883 NA 0.33 6.51 0.34 2.73e-10 Life satisfaction; LUSC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 5.94 0.31 7.23e-9 Electroencephalogram traits; LUSC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg00409905 chr10:38381863 ZNF37A -0.39 -6.61 -0.34 1.52e-10 Extrinsic epigenetic age acceleration; LUSC cis rs4363385 0.818 rs61811863 chr1:152995721 T/C cg25856811 chr1:152973957 SPRR3 -0.36 -6.0 -0.31 5.1e-9 Inflammatory skin disease; LUSC cis rs6840360 0.642 rs1443090 chr4:152451819 T/C cg20465933 chr4:152376761 FAM160A1 0.35 6.24 0.32 1.34e-9 Intelligence (multi-trait analysis); LUSC cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg12863693 chr15:85201151 NMB -0.34 -6.72 -0.34 8.04e-11 Schizophrenia; LUSC trans rs12579753 0.917 rs76240969 chr12:82195236 C/A cg07923666 chr12:49932857 KCNH3 -0.5 -6.3 -0.33 9.14e-10 Resting heart rate; LUSC cis rs7100689 0.646 rs11202724 chr10:82136190 T/C cg00277334 chr10:82204260 NA -0.51 -7.41 -0.38 1.05e-12 Post bronchodilator FEV1; LUSC cis rs7072216 0.763 rs10748729 chr10:100171371 G/C cg26618903 chr10:100175079 PYROXD2 -0.47 -8.84 -0.44 5.62e-17 Metabolite levels; LUSC cis rs9326248 0.813 rs474488 chr11:117068977 A/G cg16524733 chr11:117070046 TAGLN 0.37 5.76 0.3 1.87e-8 Blood protein levels; LUSC cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg03676636 chr4:99064102 C4orf37 0.35 7.67 0.39 1.9e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs1144713 0.606 rs1144718 chr12:32264702 T/C cg01321189 chr12:32259338 BICD1 0.46 6.83 0.35 4e-11 Obesity-related traits; LUSC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg05368731 chr17:41323189 NBR1 0.92 16.14 0.66 1.02e-43 Menopause (age at onset); LUSC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22590775 chr19:49891494 CCDC155 0.64 9.0 0.44 1.74e-17 Multiple sclerosis; LUSC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg21770322 chr7:97807741 LMTK2 0.41 7.29 0.37 2.32e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs8078723 0.714 rs2241245 chr17:38151014 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.45 7.37 0.37 1.39e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg11764359 chr7:65958608 NA 0.79 13.11 0.58 5.75e-32 Aortic root size; LUSC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg17971929 chr21:40555470 PSMG1 0.74 12.6 0.57 4.88e-30 Cognitive function; LUSC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg00343986 chr7:65444356 GUSB 0.47 7.12 0.36 6.6e-12 Calcium levels; LUSC cis rs7799006 0.691 rs10447541 chr7:2301578 T/G cg02951883 chr7:2050386 MAD1L1 -0.37 -6.08 -0.32 3.37e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.98 -0.36 1.64e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2386661 0.547 rs11259742 chr10:5647078 C/T cg17085576 chr10:5658249 NA -0.44 -6.58 -0.34 1.8e-10 Breast cancer; LUSC cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg05347473 chr6:146136440 FBXO30 0.53 8.88 0.44 4.06e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs2898681 0.581 rs10003908 chr4:53681089 T/C cg00338735 chr4:53728038 RASL11B 0.43 5.81 0.3 1.46e-8 Optic nerve measurement (cup area); LUSC cis rs2486288 0.656 rs11637364 chr15:45579238 C/T cg14582100 chr15:45693742 SPATA5L1 -0.43 -7.59 -0.38 3.16e-13 Glomerular filtration rate; LUSC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.98 0.31 5.65e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11711311 1.000 rs10934243 chr3:113430239 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.52 7.13 0.36 6.16e-12 IgG glycosylation; LUSC cis rs6565180 0.962 rs6565182 chr16:30374381 C/T cg17640201 chr16:30407289 ZNF48 -0.87 -14.35 -0.62 1.02e-36 Tonsillectomy; LUSC cis rs7189233 0.531 rs8046307 chr16:53518686 G/T cg09728985 chr16:53543985 NA -0.3 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); LUSC cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.59 -9.47 -0.46 5.41e-19 Lymphocyte counts; LUSC cis rs4692589 0.556 rs2279267 chr4:170990053 A/G cg19918862 chr4:170955249 NA -0.36 -6.48 -0.33 3.22e-10 Anxiety disorder; LUSC cis rs7589342 0.862 rs10469862 chr2:106509907 C/T cg14210321 chr2:106509881 NCK2 -0.6 -9.17 -0.45 5.11e-18 Addiction; LUSC cis rs6121246 0.567 rs6088796 chr20:30213229 C/T cg21427119 chr20:30132790 HM13 -0.43 -6.1 -0.32 3.01e-9 Mean corpuscular hemoglobin; LUSC cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs62103177 0.810 rs62096745 chr18:77619135 A/G cg14227996 chr4:17616232 MED28 0.81 8.26 0.41 3.4e-15 Opioid sensitivity; LUSC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg00074818 chr8:8560427 CLDN23 -0.55 -9.09 -0.45 9.02e-18 Obesity-related traits; LUSC cis rs708547 0.874 rs1713984 chr4:57886493 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -6.54 -0.34 2.29e-10 Response to bleomycin (chromatid breaks); LUSC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4499344 0.633 rs259246 chr19:33146154 G/C cg22980127 chr19:33182716 NUDT19 -0.44 -6.47 -0.33 3.54e-10 Mean platelet volume; LUSC cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg22601191 chr20:60968625 CABLES2 -0.42 -5.85 -0.3 1.17e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02809009 chr19:50354510 PTOV1 -0.54 -6.73 -0.35 7.6e-11 Bipolar disorder and schizophrenia; LUSC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg11764359 chr7:65958608 NA -0.51 -6.63 -0.34 1.36e-10 Aortic root size; LUSC cis rs10207060 0.778 rs6543581 chr2:240702308 C/T cg20333904 chr2:240724165 NA 0.39 7.09 0.36 7.82e-12 Obesity-related traits; LUSC cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg21535247 chr6:8435926 SLC35B3 0.57 8.96 0.44 2.28e-17 Motion sickness; LUSC cis rs6942756 0.715 rs6467242 chr7:129001173 T/A cg02491457 chr7:128862824 NA -0.5 -7.24 -0.37 3.05e-12 White matter hyperintensity burden; LUSC cis rs8062405 0.755 rs62034355 chr16:28581038 G/C cg07382826 chr16:28625726 SULT1A1 0.28 6.0 0.31 5.18e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs1348850 0.918 rs12463893 chr2:178448559 G/T cg22681709 chr2:178499509 PDE11A -0.48 -8.77 -0.43 9.06e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9921338 0.961 rs8056282 chr16:11407236 T/C cg00044050 chr16:11439710 C16orf75 -0.49 -6.5 -0.34 2.84e-10 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs2652834 1.000 rs2729782 chr15:63403354 G/C cg05507819 chr15:63340323 TPM1 0.66 8.03 0.4 1.73e-14 HDL cholesterol; LUSC cis rs68092024 0.704 rs792832 chr3:99474862 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -6.18 -0.32 1.86e-9 Cleft lip with or without cleft palate; LUSC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg06212747 chr3:49208901 KLHDC8B 0.44 6.12 0.32 2.61e-9 Parkinson's disease; LUSC cis rs9309473 0.950 rs6745480 chr2:73840055 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -6.62 -0.34 1.45e-10 Metabolite levels; LUSC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC trans rs2839186 0.934 rs17176520 chr21:47682081 T/C cg10388307 chr1:82828058 NA 0.4 6.14 0.32 2.29e-9 Testicular germ cell tumor; LUSC cis rs12681287 0.511 rs4129535 chr8:87524094 G/T cg00550725 chr8:87521180 FAM82B 0.43 5.66 0.3 3.21e-8 Caudate activity during reward; LUSC cis rs9300255 0.602 rs2695478 chr12:123689521 C/T cg13010344 chr12:123464640 ARL6IP4 -0.48 -5.87 -0.31 1.04e-8 Neutrophil percentage of white cells; LUSC cis rs11758351 0.660 rs113208674 chr6:26210465 C/G cg01420254 chr6:26195488 NA 0.65 6.99 0.36 1.54e-11 Gout;Renal underexcretion gout; LUSC cis rs2439831 1.000 rs690002 chr15:43729349 C/A cg27015174 chr15:43622946 ADAL;LCMT2 0.83 8.33 0.41 2.06e-15 Lung cancer in ever smokers; LUSC trans rs9693857 0.501 rs67985496 chr8:9263128 T/C cg06636001 chr8:8085503 FLJ10661 -0.45 -5.94 -0.31 7.04e-9 Systolic blood pressure; LUSC cis rs11645898 0.810 rs11646364 chr16:72108687 A/T cg14768367 chr16:72042858 DHODH -0.68 -7.43 -0.38 9.41e-13 Blood protein levels; LUSC trans rs208515 0.525 rs12191500 chr6:66668681 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.03 14.08 0.61 1.14e-35 Exhaled nitric oxide levels; LUSC cis rs11650494 0.831 rs7216993 chr17:47454263 A/G cg08112188 chr17:47440006 ZNF652 0.96 9.0 0.44 1.74e-17 Prostate cancer; LUSC cis rs4566357 0.964 rs4296416 chr2:227921926 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.74 -0.3 2.09e-8 Coronary artery disease; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01988500 chr16:3030808 PKMYT1 -0.41 -6.19 -0.32 1.73e-9 Hepatitis; LUSC cis rs7833986 0.501 rs72653967 chr8:56999432 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.25 0.56 9.52e-29 Height; LUSC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18758796 chr5:131593413 PDLIM4 0.53 9.17 0.45 4.88e-18 Acylcarnitine levels; LUSC cis rs7666738 0.515 rs13142498 chr4:98792443 G/T cg03676636 chr4:99064102 C4orf37 0.3 5.97 0.31 6.04e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg22823121 chr1:150693482 HORMAD1 0.51 7.47 0.38 7.01e-13 Melanoma; LUSC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg06544989 chr22:39130855 UNC84B 0.33 5.81 0.3 1.46e-8 Menopause (age at onset); LUSC cis rs1003719 0.788 rs1543749 chr21:38446621 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.29 0.53 3e-25 Eye color traits; LUSC cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs9473147 0.516 rs9395279 chr6:47542864 C/T cg12968598 chr6:47444699 CD2AP 0.52 7.79 0.39 8.3e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg06108461 chr20:60628389 TAF4 0.97 15.26 0.64 2.88e-40 Body mass index; LUSC cis rs6940638 0.688 rs2022272 chr6:27103580 A/G cg12292205 chr6:26970375 C6orf41 -0.42 -6.32 -0.33 8.26e-10 Intelligence (multi-trait analysis); LUSC trans rs7746199 0.736 rs13209332 chr6:27520752 T/A cg06606381 chr12:133084897 FBRSL1 -0.92 -8.91 -0.44 3.3e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC trans rs7937682 0.575 rs10789851 chr11:111750955 G/C cg18187862 chr3:45730750 SACM1L -0.51 -6.18 -0.32 1.83e-9 Primary sclerosing cholangitis; LUSC cis rs11031096 0.782 rs4910904 chr11:4165529 C/T cg18678763 chr11:4115507 RRM1 0.47 6.7 0.34 9.12e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg26441486 chr22:50317300 CRELD2 0.48 7.13 0.36 6.28e-12 Schizophrenia; LUSC trans rs3733585 0.699 rs17245723 chr4:9962218 A/T cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs4589502 0.800 rs4147433 chr15:67201152 G/A cg09911534 chr15:67153556 NA 0.49 6.37 0.33 6.31e-10 Lung cancer (smoking interaction); LUSC cis rs501916 0.743 rs3743281 chr15:48056958 C/T cg16110827 chr15:48056943 SEMA6D -0.49 -7.34 -0.37 1.64e-12 Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg18451016 chr1:38461880 NA 0.5 7.9 0.4 4.12e-14 Coronary artery disease; LUSC cis rs7923452 0.507 rs612802 chr10:30756441 G/A cg25182066 chr10:30743637 MAP3K8 -0.44 -6.73 -0.35 7.18e-11 Itch intensity from mosquito bite; LUSC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg26335602 chr6:28129616 ZNF389 0.46 6.34 0.33 7.57e-10 Parkinson's disease; LUSC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg00310523 chr12:86230176 RASSF9 0.44 8.25 0.41 3.7e-15 Major depressive disorder; LUSC cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg13736514 chr6:26305472 NA -0.44 -8.59 -0.43 3.45e-16 Educational attainment; LUSC cis rs7617773 0.780 rs13084616 chr3:48339699 A/G cg11946769 chr3:48343235 NME6 -0.85 -14.15 -0.61 5.93e-36 Coronary artery disease; LUSC trans rs11039798 0.844 rs41431447 chr11:48983199 A/G cg15704280 chr7:45808275 SEPT13 0.79 6.87 0.35 3.23e-11 Axial length; LUSC cis rs1505368 0.789 rs13419353 chr2:213271459 A/T cg16329650 chr2:213403929 ERBB4 -0.5 -8.69 -0.43 1.64e-16 Symmetrical dimethylarginine levels; LUSC cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg01256987 chr12:42539512 GXYLT1 -0.45 -8.48 -0.42 7.32e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg07606381 chr6:8435919 SLC35B3 0.73 12.55 0.57 7.07e-30 Motion sickness; LUSC cis rs1048238 0.506 rs848195 chr1:16286522 A/G cg21385522 chr1:16154831 NA -0.55 -8.57 -0.42 3.98e-16 Systolic blood pressure; LUSC cis rs477692 0.905 rs570967 chr10:131421330 T/G cg26102564 chr10:131424627 MGMT 0.36 5.69 0.3 2.74e-8 Response to temozolomide; LUSC cis rs1559088 0.947 rs7259879 chr19:33549462 T/C cg17764715 chr19:33622953 WDR88 0.57 7.87 0.4 4.88e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9326248 0.581 rs7121898 chr11:116796846 A/T cg20608306 chr11:116969690 SIK3 0.36 6.72 0.35 7.68e-11 Blood protein levels; LUSC trans rs4714291 0.963 rs1743973 chr6:40094549 T/G cg02267698 chr19:7991119 CTXN1 0.54 7.49 0.38 6.01e-13 Strep throat; LUSC cis rs3020736 0.500 rs6002603 chr22:42492362 C/G cg05082376 chr22:42548792 NA 0.42 6.39 0.33 5.56e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs722599 0.683 rs10139016 chr14:75274288 T/C cg06637938 chr14:75390232 RPS6KL1 0.4 5.68 0.3 2.89e-8 IgG glycosylation; LUSC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg05368731 chr17:41323189 NBR1 0.78 12.85 0.58 5.65e-31 Menopause (age at onset); LUSC cis rs427941 0.632 rs201507 chr7:101764141 T/C cg06246474 chr7:101738831 CUX1 0.39 6.39 0.33 5.63e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs9788682 0.706 rs924840 chr15:78731808 A/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.95 -0.31 6.8e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg07424592 chr7:64974309 NA 0.7 6.05 0.31 3.99e-9 Diabetic kidney disease; LUSC cis rs113835537 0.529 rs7950407 chr11:66258006 A/G cg24851651 chr11:66362959 CCS 0.55 8.27 0.41 3.16e-15 Airway imaging phenotypes; LUSC trans rs4714291 0.674 rs3008837 chr6:40046725 C/T cg02267698 chr19:7991119 CTXN1 -0.55 -7.99 -0.4 2.25e-14 Strep throat; LUSC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.39 6.31 0.33 8.78e-10 Intelligence (multi-trait analysis); LUSC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg15383120 chr6:291909 DUSP22 -0.48 -7.41 -0.38 1.04e-12 Menopause (age at onset); LUSC cis rs11190604 1.000 rs2495750 chr10:102327708 A/G cg07080220 chr10:102295463 HIF1AN 0.7 8.65 0.43 2.15e-16 Palmitoleic acid (16:1n-7) levels; LUSC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg22907277 chr7:1156413 C7orf50 0.57 8.87 0.44 4.56e-17 Longevity;Endometriosis; LUSC cis rs11758351 1.000 rs3734530 chr6:26195408 G/C cg11342453 chr6:26196699 NA 0.55 5.78 0.3 1.7e-8 Gout;Renal underexcretion gout; LUSC cis rs3091242 0.967 rs3091240 chr1:25676935 G/T cg20684491 chr1:25596433 NA 0.41 6.41 0.33 5.09e-10 Erythrocyte sedimentation rate; LUSC cis rs6835098 1.000 rs1054496 chr4:174089080 A/G cg08422745 chr4:174089978 GALNT7 -0.78 -11.81 -0.54 4.07e-27 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs10504229 0.773 rs1874374 chr8:58194422 A/G cg24829409 chr8:58192753 C8orf71 -0.65 -6.57 -0.34 1.94e-10 Developmental language disorder (linguistic errors); LUSC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg22875332 chr1:76189707 ACADM 0.82 14.39 0.62 7.5e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs7267979 1.000 rs6076345 chr20:25381895 T/G cg03522245 chr20:25566470 NINL -0.35 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg23711669 chr6:146136114 FBXO30 0.85 15.47 0.65 4.32e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs7208859 0.623 rs7208441 chr17:29143863 C/T cg13385521 chr17:29058706 SUZ12P 0.67 6.62 0.34 1.47e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs2191566 1.000 rs390369 chr19:44506984 C/T cg03039196 chr19:44506973 ZNF230 -0.36 -6.04 -0.31 4.08e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.64 0.63 8.06e-38 Allergic disease (asthma, hay fever or eczema); LUSC cis rs2806561 0.765 rs652706 chr1:23514246 G/A cg12483005 chr1:23474871 LUZP1 0.42 6.62 0.34 1.4e-10 Height; LUSC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg20203395 chr5:56204925 C5orf35 -0.7 -7.81 -0.39 7.26e-14 Type 2 diabetes; LUSC cis rs6424115 0.557 rs35904775 chr1:24180623 T/C cg10978503 chr1:24200527 CNR2 -0.52 -12.47 -0.56 1.48e-29 Immature fraction of reticulocytes; LUSC cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.48 6.91 0.35 2.49e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg05347473 chr6:146136440 FBXO30 0.44 7.64 0.39 2.25e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs2197308 0.606 rs12314897 chr12:38392293 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.67 -0.34 1.03e-10 Morning vs. evening chronotype; LUSC cis rs6696846 0.740 rs12125465 chr1:205074854 C/A cg03948781 chr1:205179583 DSTYK 0.33 6.46 0.33 3.66e-10 Red blood cell count; LUSC cis rs614226 1.000 rs563920 chr12:121017439 A/G cg27489772 chr12:121021490 NA 0.59 7.79 0.39 8.52e-14 Type 1 diabetes nephropathy; LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg24829409 chr8:58192753 C8orf71 -0.57 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); LUSC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg16339924 chr4:17578868 LAP3 0.54 8.36 0.42 1.69e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg06112835 chr11:68658793 MRPL21 0.52 7.92 0.4 3.5e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC trans rs3733585 0.699 rs6449177 chr4:9968050 T/C cg26043149 chr18:55253948 FECH -0.46 -7.02 -0.36 1.27e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12936587 0.564 rs7208561 chr17:17615528 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.49 7.58 0.38 3.41e-13 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; LUSC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.31 -0.33 8.8e-10 Lung cancer; LUSC trans rs62055045 0.528 rs62056191 chr16:71533831 C/T cg15281710 chr15:96890452 NA -0.48 -6.85 -0.35 3.55e-11 Schizophrenia; LUSC cis rs11642862 0.901 rs11642733 chr16:30969061 G/A cg02466173 chr16:30829666 NA -0.63 -6.45 -0.33 3.9e-10 Tonsillectomy; LUSC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg03676636 chr4:99064102 C4orf37 -0.36 -7.66 -0.39 2.04e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.51 0.53 4.82e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg13531842 chr10:38383804 ZNF37A -0.44 -6.72 -0.35 7.84e-11 Extrinsic epigenetic age acceleration; LUSC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg05347473 chr6:146136440 FBXO30 0.66 11.42 0.53 1.04e-25 Lobe attachment (rater-scored or self-reported); LUSC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -6.35 -0.33 6.97e-10 Total body bone mineral density; LUSC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg05347473 chr6:146136440 FBXO30 0.66 11.7 0.54 9.84e-27 Lobe attachment (rater-scored or self-reported); LUSC trans rs4332037 0.538 rs4721164 chr7:1932629 C/G cg11693508 chr17:37793320 STARD3 0.52 7.13 0.36 6.4e-12 Bipolar disorder; LUSC cis rs4319547 0.614 rs10846764 chr12:122874297 T/C cg05707623 chr12:122985044 ZCCHC8 0.66 8.16 0.41 6.76e-15 Body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20632863 chr12:99038768 APAF1;IKBIP -0.44 -6.6 -0.34 1.6e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs61931739 0.534 rs1817761 chr12:34105719 C/T cg06521331 chr12:34319734 NA -0.48 -7.77 -0.39 9.54e-14 Morning vs. evening chronotype; LUSC cis rs6142102 0.961 rs1883524 chr20:32626107 G/A cg08999081 chr20:33150536 PIGU 0.34 5.85 0.3 1.16e-8 Skin pigmentation; LUSC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg00825309 chr19:58991885 ZNF446 -0.5 -7.16 -0.36 5.17e-12 Uric acid clearance; LUSC trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg13615516 chr5:77269221 NA 0.41 6.86 0.35 3.31e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg03929089 chr4:120376271 NA -0.94 -16.46 -0.67 5.66e-45 Height; LUSC cis rs734999 0.566 rs6424092 chr1:2532899 C/A cg18854424 chr1:2615690 NA -0.49 -9.81 -0.47 3.96e-20 Ulcerative colitis; LUSC cis rs1448094 0.842 rs7309725 chr12:86440612 T/C cg02569458 chr12:86230093 RASSF9 0.37 5.99 0.31 5.44e-9 Major depressive disorder; LUSC cis rs7191439 0.858 rs8050715 chr16:88780923 C/G cg26217441 chr16:89643414 CPNE7 -0.48 -5.69 -0.3 2.71e-8 Plateletcrit; LUSC cis rs2932538 0.922 rs12402469 chr1:113076625 G/A cg22162597 chr1:113214053 CAPZA1 0.72 10.22 0.49 1.58e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs34779708 0.733 rs3936502 chr10:35549218 C/T cg03585969 chr10:35415529 CREM 0.52 7.25 0.37 2.96e-12 Inflammatory bowel disease;Crohn's disease; LUSC trans rs9951602 0.512 rs7237214 chr18:76657394 C/G cg02800362 chr5:177631904 HNRNPAB 0.88 12.72 0.57 1.72e-30 Obesity-related traits; LUSC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg04317338 chr11:64019027 PLCB3 0.66 7.51 0.38 5.28e-13 Mean platelet volume; LUSC cis rs11098499 0.863 rs13136462 chr4:120543173 C/T cg24375607 chr4:120327624 NA 0.73 10.98 0.52 3.62e-24 Corneal astigmatism; LUSC cis rs9430161 0.611 rs34032547 chr1:11034374 C/G cg27631724 chr1:11040367 C1orf127 0.54 9.4 0.46 8.69e-19 Ewing sarcoma; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg02562052 chr2:202508330 ALS2CR4 0.35 6.03 0.31 4.44e-9 Tuberculosis; LUSC cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg23625390 chr15:77176239 SCAPER 0.52 7.98 0.4 2.3e-14 Blood metabolite levels; LUSC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg01879757 chr17:41196368 BRCA1 -0.48 -7.66 -0.39 2.04e-13 Menopause (age at onset); LUSC cis rs2235649 0.833 rs9922139 chr16:1848329 G/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.45 -6.15 -0.32 2.17e-9 Blood metabolite levels; LUSC cis rs7666738 0.530 rs2865992 chr4:99067181 A/T cg05340658 chr4:99064831 C4orf37 0.45 7.2 0.37 3.97e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs8141529 0.644 rs5752795 chr22:29178820 T/C cg02153584 chr22:29168773 CCDC117 0.66 10.72 0.51 3.16e-23 Lymphocyte counts; LUSC cis rs8036030 0.604 rs11856835 chr15:74716174 G/A cg14664628 chr15:75095509 CSK -0.4 -5.93 -0.31 7.59e-9 Airflow obstruction; LUSC cis rs7178572 1.000 rs6495240 chr15:77766556 T/C cg22256960 chr15:77711686 NA -0.55 -9.2 -0.45 4.07e-18 Type 2 diabetes; LUSC trans rs4650994 0.524 rs2761465 chr1:178579404 G/T cg05059571 chr16:84539110 KIAA1609 0.46 8.67 0.43 1.89e-16 HDL cholesterol levels;HDL cholesterol; LUSC cis rs1949733 1.000 rs3103072 chr4:8508431 C/T cg11789530 chr4:8429930 ACOX3 -0.6 -8.76 -0.43 1e-16 Response to antineoplastic agents; LUSC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 14.18 0.61 4.56e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg20398880 chr6:41068722 NFYA;LOC221442 -0.37 -5.89 -0.31 9.63e-9 Alzheimer's disease (late onset); LUSC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg07424592 chr7:64974309 NA 0.69 6.08 0.32 3.28e-9 Diabetic kidney disease; LUSC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg12024160 chr4:1254474 NA 0.32 6.01 0.31 4.98e-9 Obesity-related traits; LUSC cis rs1729951 0.575 rs16844326 chr3:136678385 G/C cg12473912 chr3:136751656 NA 0.39 6.77 0.35 5.97e-11 Neuroticism; LUSC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg06850241 chr22:41845214 NA 0.31 5.72 0.3 2.39e-8 Vitiligo; LUSC cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.33 0.56 4.77e-29 Colorectal cancer; LUSC cis rs1775715 0.737 rs55859032 chr10:32213239 C/T cg03015672 chr10:32216066 ARHGAP12 0.32 5.81 0.3 1.47e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs2835872 0.965 rs857976 chr21:39001177 A/C cg20424643 chr21:39039972 KCNJ6 0.42 6.33 0.33 7.91e-10 Electroencephalographic traits in alcoholism; LUSC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.75 0.39 1.1e-13 Electroencephalogram traits; LUSC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg18876405 chr7:65276391 NA -0.65 -11.6 -0.54 2.18e-26 Aortic root size; LUSC cis rs1443512 0.812 rs1992563 chr12:54330441 G/T cg17410650 chr12:54324560 NA -0.59 -10.58 -0.5 9.56e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs10489202 0.608 rs10918827 chr1:168077044 A/G cg24449463 chr1:168025552 DCAF6 0.64 9.77 0.47 5.36e-20 Schizophrenia; LUSC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg10487724 chr17:56770010 TEX14;RAD51C -0.44 -6.99 -0.36 1.49e-11 Intelligence (multi-trait analysis); LUSC cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -7.59 -0.38 3.21e-13 Personality dimensions; LUSC cis rs2303282 0.716 rs2617847 chr16:56397174 C/G cg00500540 chr16:56394104 NA -0.44 -7.55 -0.38 4.1e-13 Breast cancer; LUSC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg08219700 chr8:58056026 NA 0.65 7.22 0.37 3.6e-12 Developmental language disorder (linguistic errors); LUSC cis rs652260 1.000 rs604938 chr19:7903484 A/G cg26014689 chr19:7917955 EVI5L 0.44 7.82 0.39 7.01e-14 Menarche (age at onset); LUSC cis rs73206853 0.841 rs7963504 chr12:110906880 C/A cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.33 3.57e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs1048238 0.506 rs12023422 chr1:16187625 G/A cg21385522 chr1:16154831 NA 0.56 8.46 0.42 8.3e-16 Systolic blood pressure; LUSC cis rs3771570 0.786 rs62186396 chr2:242221219 A/G cg21155796 chr2:242212141 HDLBP 0.64 6.95 0.36 1.9e-11 Prostate cancer; LUSC cis rs10779751 0.770 rs10864490 chr1:11236410 A/C cg08854313 chr1:11322531 MTOR 0.85 12.75 0.57 1.29e-30 Body mass index; LUSC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.52 0.34 2.67e-10 Lung cancer; LUSC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg09238746 chr17:78121135 EIF4A3 -0.83 -13.21 -0.59 2.49e-32 Yeast infection; LUSC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs7106204 0.609 rs55751762 chr11:24296146 C/T ch.11.24196551F chr11:24239977 NA 0.69 5.68 0.3 2.86e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9283706 0.689 rs10041705 chr5:66317222 C/T cg11590213 chr5:66331682 MAST4 -0.43 -6.46 -0.33 3.64e-10 Coronary artery disease; LUSC cis rs5758511 0.689 rs11913578 chr22:42347391 A/C cg00645731 chr22:42541494 CYP2D7P1 0.45 7.39 0.37 1.17e-12 Birth weight; LUSC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg05025164 chr4:1340916 KIAA1530 0.51 8.03 0.4 1.74e-14 Longevity; LUSC cis rs12541635 0.677 rs1006480 chr8:106975524 T/C cg10147462 chr8:107024639 NA 0.64 12.92 0.58 3.03e-31 Age of smoking initiation; LUSC cis rs8060686 0.641 rs7201742 chr16:68099821 T/G cg05110241 chr16:68378359 PRMT7 -0.52 -6.2 -0.32 1.64e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg14784868 chr12:69753453 YEATS4 0.92 16.31 0.67 2.09e-44 Cerebrospinal fluid biomarker levels; LUSC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs7267979 0.586 rs6050432 chr20:25184028 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.67 12.48 0.56 1.32e-29 Liver enzyme levels (alkaline phosphatase); LUSC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg08680598 chr22:49984980 NA 0.36 6.88 0.35 2.92e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg24733560 chr20:60626293 TAF4 0.43 7.82 0.39 6.95e-14 Body mass index; LUSC cis rs72781680 1.000 rs72788286 chr2:24098321 A/C cg08917208 chr2:24149416 ATAD2B 0.87 9.99 0.48 9.5e-21 Lymphocyte counts; LUSC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.07 0.52 1.76e-24 Alzheimer's disease; LUSC cis rs9527 0.615 rs7080462 chr10:104736699 T/C cg05855489 chr10:104503620 C10orf26 0.52 8.0 0.4 2.12e-14 Arsenic metabolism; LUSC cis rs1178968 0.748 rs10248063 chr7:72776008 T/G cg25889504 chr7:72793014 NA 0.6 7.8 0.39 7.86e-14 Triglyceride levels; LUSC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.84 13.09 0.58 6.8e-32 Cognitive test performance; LUSC cis rs9807989 0.507 rs1592459 chr2:103031569 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma; LUSC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg03676636 chr4:99064102 C4orf37 0.33 7.26 0.37 2.75e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10791097 0.547 rs3829271 chr11:130753912 T/A cg12179176 chr11:130786555 SNX19 0.84 14.74 0.63 3.18e-38 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs34779708 0.966 rs1478463 chr10:35473035 G/A cg03585969 chr10:35415529 CREM 0.63 9.47 0.46 5.31e-19 Inflammatory bowel disease;Crohn's disease; LUSC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg05872129 chr22:39784769 NA -0.62 -11.68 -0.54 1.17e-26 Intelligence (multi-trait analysis); LUSC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg18681998 chr4:17616180 MED28 0.85 15.41 0.64 7.31e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg19748678 chr4:122722346 EXOSC9 0.74 11.23 0.52 4.98e-25 Type 2 diabetes; LUSC cis rs5769707 0.521 rs7285764 chr22:50058561 T/C cg10356904 chr22:49881777 NA -0.3 -5.94 -0.31 7.14e-9 Monocyte count;Monocyte percentage of white cells; LUSC trans rs6772840 1.000 rs17076032 chr3:43822972 A/G cg11173822 chr5:101925501 NA 0.42 6.26 0.32 1.21e-9 Subjective well-being; LUSC cis rs1003719 0.715 rs2835657 chr21:38565064 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -10.0 -0.48 8.91e-21 Eye color traits; LUSC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg01475377 chr6:109611718 NA -0.37 -6.56 -0.34 2.04e-10 Reticulocyte fraction of red cells; LUSC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.11 -0.32 2.81e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2739330 0.828 rs4822451 chr22:24248166 T/G cg11060661 chr22:24314208 DDT;DDTL 0.5 8.07 0.4 1.27e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12618769 0.570 rs116051325 chr2:99056836 G/A cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.14e-13 Bipolar disorder; LUSC cis rs12474201 0.963 rs3829835 chr2:46925789 C/T cg06386533 chr2:46925753 SOCS5 0.8 12.28 0.56 7.34e-29 Height; LUSC cis rs4253772 0.530 rs9615349 chr22:46732418 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.61 5.91 0.31 8.59e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs11758351 1.000 rs16891397 chr6:26200256 C/T cg23601095 chr6:26197514 HIST1H3D 0.73 7.5 0.38 5.79e-13 Gout;Renal underexcretion gout; LUSC cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg01765077 chr12:122356316 WDR66 -0.5 -7.22 -0.37 3.47e-12 Mean corpuscular volume; LUSC cis rs6977660 0.714 rs2390156 chr7:19786138 A/T cg05791153 chr7:19748676 TWISTNB 0.75 7.42 0.38 1.01e-12 Thyroid stimulating hormone; LUSC cis rs7223966 1.000 rs9899491 chr17:61934384 G/C cg05941027 chr17:61774174 LIMD2 0.22 5.88 0.31 9.68e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.79 0.35 5.19e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs12477438 0.765 rs28648058 chr2:99696417 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.79 -0.51 1.67e-23 Chronic sinus infection; LUSC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg12463550 chr7:65579703 CRCP 0.51 7.34 0.37 1.6e-12 Aortic root size; LUSC cis rs977987 0.843 rs17696749 chr16:75403062 C/G cg03315344 chr16:75512273 CHST6 0.53 10.36 0.49 5.48e-22 Dupuytren's disease; LUSC cis rs4820539 0.933 rs2267004 chr22:23459863 G/A cg14186256 chr22:23484241 RTDR1 0.91 16.35 0.67 1.52e-44 Bone mineral density; LUSC cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg06550200 chr5:1325588 CLPTM1L -0.65 -10.96 -0.51 4.26e-24 Lung cancer; LUSC cis rs6964587 1.000 rs3753108 chr7:91629984 T/G cg17063962 chr7:91808500 NA 0.57 9.06 0.44 1.1e-17 Breast cancer; LUSC cis rs2295359 0.892 rs56920441 chr1:67652012 A/G cg12940439 chr1:67600707 NA 0.37 6.08 0.32 3.2e-9 Psoriasis; LUSC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg18252515 chr7:66147081 NA -1.25 -13.99 -0.61 2.56e-35 Diabetic kidney disease; LUSC trans rs7824557 0.564 rs13260727 chr8:11232860 A/G cg15556689 chr8:8085844 FLJ10661 0.48 7.22 0.37 3.5e-12 Retinal vascular caliber; LUSC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg09365446 chr1:150670422 GOLPH3L 0.54 8.28 0.41 2.91e-15 Tonsillectomy; LUSC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg21770322 chr7:97807741 LMTK2 0.4 6.91 0.35 2.41e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg08847533 chr14:75593920 NEK9 0.84 15.57 0.65 1.85e-41 Height; LUSC cis rs12950390 0.853 rs56363619 chr17:45854621 T/C cg03474202 chr17:45855739 NA -0.29 -6.69 -0.34 9.51e-11 IgG glycosylation; LUSC cis rs2901656 0.714 rs10798026 chr1:172453840 T/C cg03748243 chr1:172413542 C1orf105;PIGC 0.3 5.94 0.31 7.04e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.35e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs68170813 0.641 rs12534124 chr7:107119047 G/A cg02696742 chr7:106810147 HBP1 -0.66 -9.82 -0.47 3.6e-20 Coronary artery disease; LUSC cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg10523679 chr1:76189770 ACADM -0.47 -6.98 -0.36 1.58e-11 Daytime sleep phenotypes; LUSC cis rs9660992 0.710 rs1151787 chr1:205254238 G/A cg21545522 chr1:205238299 TMCC2 0.51 9.51 0.46 3.91e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4953404 0.613 rs4355163 chr2:46909817 G/C cg09399716 chr2:46890238 NA -0.3 -6.63 -0.34 1.34e-10 Pulse pressure (alcohol consumption interaction); LUSC cis rs3125734 0.633 rs1873685 chr10:64032126 C/T cg09941381 chr10:64027924 RTKN2 -0.4 -7.23 -0.37 3.22e-12 Rheumatoid arthritis; LUSC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.53 0.6 1.44e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9527 0.590 rs34104646 chr10:104896078 T/A cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg11645453 chr3:52864694 ITIH4 0.35 8.14 0.41 7.76e-15 Bipolar disorder; LUSC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg20295408 chr7:1910781 MAD1L1 0.42 5.98 0.31 5.66e-9 Bipolar disorder and schizophrenia; LUSC cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg23229984 chr5:148520753 ABLIM3 0.37 5.66 0.3 3.18e-8 Breast cancer; LUSC cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg11584989 chr19:19387371 SF4 0.57 6.57 0.34 1.99e-10 Bipolar disorder; LUSC cis rs614226 1.000 rs1167727 chr12:120965508 C/A cg21053147 chr12:120880522 NA -0.49 -6.06 -0.31 3.57e-9 Type 1 diabetes nephropathy; LUSC cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg01884057 chr2:25150051 NA -0.46 -10.93 -0.51 5.69e-24 Body mass index; LUSC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.8 -0.35 4.82e-11 Alzheimer's disease (late onset); LUSC cis rs7590368 0.715 rs12475790 chr2:10957907 A/C cg15705551 chr2:10952987 PDIA6 0.58 6.24 0.32 1.31e-9 Educational attainment (years of education); LUSC cis rs9326248 0.861 rs11216172 chr11:116749878 G/A cg01368799 chr11:117014884 PAFAH1B2 0.49 6.34 0.33 7.24e-10 Blood protein levels; LUSC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg09877947 chr5:131593287 PDLIM4 0.49 8.03 0.4 1.68e-14 Breast cancer; LUSC cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg00321850 chr1:175162397 KIAA0040 0.46 7.86 0.4 5.38e-14 Alcohol dependence; LUSC cis rs8064299 0.967 rs3744208 chr17:72767565 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.66 11.35 0.53 1.76e-25 Monocyte count; LUSC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg09267113 chr7:98030324 BAIAP2L1 0.38 5.78 0.3 1.74e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9372498 0.536 rs72952793 chr6:118892979 T/A cg18833306 chr6:118973337 C6orf204 -0.46 -5.85 -0.3 1.16e-8 Diastolic blood pressure; LUSC cis rs11098499 0.697 rs4560394 chr4:120313435 T/G cg09307838 chr4:120376055 NA 0.78 11.25 0.52 4.06e-25 Corneal astigmatism; LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg08219700 chr8:58056026 NA 0.66 7.72 0.39 1.41e-13 Developmental language disorder (linguistic errors); LUSC cis rs6424115 0.830 rs1106 chr1:24200772 C/G cg15997130 chr1:24165203 NA 0.52 8.58 0.43 3.6e-16 Immature fraction of reticulocytes; LUSC cis rs4820294 1.000 rs41280035 chr22:38054038 A/G cg21798802 chr22:38057573 PDXP 0.46 9.76 0.47 5.77e-20 Fat distribution (HIV); LUSC cis rs11098499 0.863 rs7678400 chr4:120461957 G/A cg09307838 chr4:120376055 NA 0.75 10.7 0.51 3.49e-23 Corneal astigmatism; LUSC cis rs10876993 0.890 rs12302351 chr12:58062590 T/C cg15848620 chr12:58087721 OS9 -0.54 -7.71 -0.39 1.47e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs5758659 0.652 rs133313 chr22:42401749 G/T cg15557168 chr22:42548783 NA -0.33 -5.72 -0.3 2.43e-8 Cognitive function; LUSC cis rs73206853 0.610 rs73194020 chr12:111131366 G/A cg12870014 chr12:110450643 ANKRD13A 0.69 6.73 0.35 7.61e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs7520050 0.771 rs4660882 chr1:46116292 C/T cg24296786 chr1:45957014 TESK2 -0.41 -5.81 -0.3 1.47e-8 Red blood cell count;Reticulocyte count; LUSC cis rs6693567 0.565 rs1260458 chr1:150347454 C/T cg15654264 chr1:150340011 RPRD2 0.44 7.04 0.36 1.11e-11 Migraine; LUSC cis rs4664308 0.618 rs17830904 chr2:160891688 C/T cg03641300 chr2:160917029 PLA2R1 0.47 7.83 0.39 6.58e-14 Idiopathic membranous nephropathy; LUSC cis rs9326248 0.581 rs10892061 chr11:116886114 C/T cg01368799 chr11:117014884 PAFAH1B2 0.61 9.45 0.46 6.17e-19 Blood protein levels; LUSC cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg03146154 chr1:46216737 IPP 0.5 7.41 0.38 1.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg17490921 chr11:116658887 ZNF259 0.36 6.02 0.31 4.63e-9 Triglycerides; LUSC cis rs4253772 0.550 rs9615953 chr22:46731024 C/G cg09491104 chr22:46646882 C22orf40 -0.61 -6.38 -0.33 5.85e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs2479724 0.569 rs75720073 chr6:41750301 T/A cg17623882 chr6:41773611 USP49 0.51 6.77 0.35 5.93e-11 Menarche (age at onset); LUSC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.49 8.18 0.41 6.01e-15 Lymphocyte counts; LUSC cis rs6681460 1.000 rs2031478 chr1:67123742 C/A cg02459107 chr1:67143332 SGIP1 0.47 8.95 0.44 2.48e-17 Presence of antiphospholipid antibodies; LUSC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 6.51 0.34 2.8e-10 Schizophrenia; LUSC cis rs977987 0.778 rs35415181 chr16:75403124 T/C cg04384234 chr16:75411784 CFDP1 -0.42 -6.94 -0.36 2e-11 Dupuytren's disease; LUSC cis rs7582180 0.903 rs2309826 chr2:100905274 C/A cg08017756 chr2:100939284 LONRF2 -0.37 -6.24 -0.32 1.31e-9 Intelligence (multi-trait analysis); LUSC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg14552801 chr7:65878734 NA 0.37 5.85 0.3 1.18e-8 Aortic root size; LUSC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg11645453 chr3:52864694 ITIH4 0.33 7.64 0.39 2.35e-13 Bipolar disorder; LUSC cis rs8099014 0.906 rs9953884 chr18:56093448 A/C cg12907477 chr18:56117327 MIR122 0.43 6.74 0.35 6.92e-11 Platelet count; LUSC cis rs950169 0.579 rs881983 chr15:84647308 C/T cg17507749 chr15:85114479 UBE2QP1 0.51 5.89 0.31 9.3e-9 Schizophrenia; LUSC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.54 9.43 0.46 7.08e-19 Bipolar disorder; LUSC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.34 0.42 1.98e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.19 -0.52 6.61e-25 Alzheimer's disease; LUSC cis rs4851254 0.961 rs11692215 chr2:100746573 C/T cg07810366 chr2:100720526 AFF3 -0.36 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); LUSC cis rs3213961 0.529 rs6708 chr2:33789534 A/G cg04131969 chr2:33951647 MYADML 0.48 5.88 0.31 1.01e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs1030268 0.715 rs13235840 chr7:133505091 A/T cg10665199 chr7:133106180 EXOC4 0.54 5.89 0.31 9.27e-9 Intelligence (multi-trait analysis); LUSC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.55 7.59 0.38 3.17e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs629535 0.773 rs686683 chr8:70070364 G/A cg21567404 chr3:27674614 NA 0.98 15.66 0.65 7.7e-42 Dupuytren's disease; LUSC cis rs1953600 0.818 rs2152546 chr10:81906384 G/T cg00277334 chr10:82204260 NA -0.48 -7.41 -0.38 1.06e-12 Sarcoidosis; LUSC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg14829155 chr15:31115871 NA -0.7 -10.3 -0.49 8.79e-22 Huntington's disease progression; LUSC cis rs6840360 0.642 rs11099819 chr4:152430178 T/C cg20465933 chr4:152376761 FAM160A1 0.33 5.94 0.31 7.18e-9 Intelligence (multi-trait analysis); LUSC cis rs77106637 0.860 rs75896506 chr11:72429579 G/A cg04827223 chr11:72435913 ARAP1 -0.79 -8.85 -0.44 5.13e-17 Type 2 diabetes; LUSC trans rs62055045 0.528 rs9935288 chr16:71552741 T/C cg21834679 chr15:96891026 NA -0.38 -6.18 -0.32 1.89e-9 Schizophrenia; LUSC cis rs7582180 0.652 rs4443016 chr2:100876628 C/G cg08017756 chr2:100939284 LONRF2 -0.33 -5.9 -0.31 8.83e-9 Intelligence (multi-trait analysis); LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg08088566 chr11:430123 ANO9 0.59 6.96 0.36 1.76e-11 Body mass index; LUSC cis rs7267979 1.000 rs6083809 chr20:25329309 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.88 -20.56 -0.75 2.74e-61 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7241530 0.717 rs28445036 chr18:75889191 G/A cg14642773 chr18:75888474 NA 0.36 6.04 0.31 4.18e-9 Educational attainment (years of education); LUSC cis rs9815354 0.812 rs111277902 chr3:41950312 C/T cg03022575 chr3:42003672 ULK4 0.83 8.63 0.43 2.55e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7178572 0.568 rs28524916 chr15:77599002 T/A cg22256960 chr15:77711686 NA 0.49 7.8 0.39 7.96e-14 Type 2 diabetes; LUSC cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg00530320 chr1:46809349 NSUN4 0.55 8.46 0.42 8.29e-16 Menopause (age at onset); LUSC cis rs2625529 0.652 rs28650442 chr15:72155445 A/T cg16672083 chr15:72433130 SENP8 -0.48 -8.08 -0.4 1.23e-14 Red blood cell count; LUSC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs6599077 0.950 rs2887954 chr3:40101924 A/G cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg14403583 chr14:105418241 AHNAK2 -0.57 -9.55 -0.46 2.94e-19 Rheumatoid arthritis; LUSC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg17385448 chr1:15911702 AGMAT 0.36 6.09 0.32 3.12e-9 Systolic blood pressure; LUSC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.07 0.31 3.56e-9 Schizophrenia; LUSC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.16 -0.32 2.06e-9 Joint mobility (Beighton score); LUSC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg23711669 chr6:146136114 FBXO30 0.91 17.59 0.69 1.71e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 7.92 0.4 3.66e-14 Axial length; LUSC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg00677455 chr12:58241039 CTDSP2 0.62 8.62 0.43 2.7e-16 Multiple sclerosis; LUSC cis rs6088813 0.883 rs2425061 chr20:33915571 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.37 -5.94 -0.31 7.03e-9 Height; LUSC cis rs8038465 0.638 rs56262972 chr15:73946745 G/A cg15420318 chr15:73925796 NPTN 0.6 10.15 0.49 2.93e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg11060661 chr22:24314208 DDT;DDTL -0.42 -7.3 -0.37 2.06e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg18099408 chr3:52552593 STAB1 -0.43 -7.32 -0.37 1.88e-12 Bipolar disorder; LUSC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg16049864 chr8:95962084 TP53INP1 -0.64 -11.85 -0.54 2.72e-27 Type 2 diabetes; LUSC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.57e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg04267008 chr7:1944627 MAD1L1 -0.51 -7.69 -0.39 1.68e-13 Bipolar disorder and schizophrenia; LUSC cis rs2455601 0.786 rs3763913 chr11:8951230 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -8.28 -0.41 3.03e-15 Schizophrenia; LUSC cis rs7592578 0.599 rs62180992 chr2:191285732 A/G cg10560079 chr2:191398806 TMEM194B -0.59 -6.88 -0.35 3e-11 Diastolic blood pressure; LUSC cis rs28595532 0.702 rs56217716 chr4:119338490 T/G cg21605333 chr4:119757512 SEC24D 1.02 8.34 0.42 1.96e-15 Cannabis dependence symptom count; LUSC cis rs68170813 0.617 rs2283041 chr7:107190415 A/G cg02696742 chr7:106810147 HBP1 -0.64 -8.61 -0.43 2.99e-16 Coronary artery disease; LUSC cis rs10465746 0.967 rs11163876 chr1:84440605 T/C cg10977910 chr1:84465055 TTLL7 0.42 6.23 0.32 1.42e-9 Obesity-related traits; LUSC cis rs636291 0.500 rs655271 chr1:10536635 G/A cg17425144 chr1:10567563 PEX14 0.61 12.48 0.56 1.33e-29 Prostate cancer; LUSC trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg17470723 chr8:74884337 TCEB1 0.52 8.19 0.41 5.53e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs41271473 0.519 rs9660783 chr1:228886880 C/T cg10167378 chr1:228756711 NA 0.46 6.53 0.34 2.43e-10 Chronic lymphocytic leukemia; LUSC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14262678 chr6:151773367 RMND1;C6orf211 0.47 7.7 0.39 1.55e-13 Menarche (age at onset); LUSC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg22535103 chr8:58192502 C8orf71 -0.78 -7.86 -0.4 5.23e-14 Developmental language disorder (linguistic errors); LUSC cis rs6835098 1.000 rs2332654 chr4:174088399 C/T cg08422745 chr4:174089978 GALNT7 -0.82 -13.37 -0.59 6.09e-33 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs9633740 1.000 rs9633740 chr10:82265271 A/G cg01528321 chr10:82214614 TSPAN14 1.08 12.25 0.56 9.24e-29 Post bronchodilator FEV1; LUSC cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg26384229 chr12:38710491 ALG10B -0.82 -15.37 -0.64 1.05e-40 Heart rate; LUSC cis rs11587400 0.679 rs12090305 chr1:115109441 G/A cg12756093 chr1:115239321 AMPD1 0.4 5.93 0.31 7.76e-9 Autism; LUSC cis rs11630290 0.774 rs57085979 chr15:64133689 T/C cg12036633 chr15:63758958 NA -0.59 -6.67 -0.34 1.03e-10 Iris characteristics; LUSC trans rs9395865 0.501 rs2067833 chr6:53330356 A/G cg06503243 chr13:42006994 OR7E37P -0.37 -6.23 -0.32 1.39e-9 Electroencephalographic traits in alcoholism; LUSC cis rs9463078 0.605 rs3799984 chr6:44893640 C/G cg25276700 chr6:44698697 NA 0.3 6.24 0.32 1.3e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs7681440 0.626 rs2289515 chr4:90816790 T/A cg15133208 chr4:90757351 SNCA -0.33 -5.66 -0.3 3.29e-8 Dementia with Lewy bodies; LUSC cis rs7267979 1.000 rs4815409 chr20:25346697 C/A cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3771570 0.901 rs4675969 chr2:242217627 C/T cg21155796 chr2:242212141 HDLBP 0.59 6.92 0.35 2.39e-11 Prostate cancer; LUSC cis rs11098499 0.730 rs12505735 chr4:120532956 G/T cg09307838 chr4:120376055 NA 0.65 9.33 0.45 1.56e-18 Corneal astigmatism; LUSC trans rs7739264 0.602 rs9350179 chr6:19764095 G/A cg16463452 chr13:29195249 NA 0.3 6.02 0.31 4.56e-9 Endometriosis; LUSC cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg06784218 chr1:46089804 CCDC17 -0.58 -11.55 -0.53 3.58e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.4 -0.33 5.22e-10 Extrinsic epigenetic age acceleration; LUSC trans rs7647973 0.626 rs4855846 chr3:49683526 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.87 -0.35 3.11e-11 Menarche (age at onset); LUSC trans rs7824557 0.564 rs55758514 chr8:11230259 A/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.83 -0.39 6.64e-14 Retinal vascular caliber; LUSC cis rs7246657 0.891 rs7257495 chr19:37823876 C/G cg23950597 chr19:37808831 NA -0.65 -7.91 -0.4 3.9e-14 Coronary artery calcification; LUSC cis rs11018904 0.906 rs36177012 chr11:89933319 T/C cg26138821 chr11:89956704 CHORDC1 -0.6 -6.94 -0.35 2.09e-11 Intelligence (multi-trait analysis); LUSC cis rs9811920 0.809 rs35422475 chr3:99711545 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.59 -0.34 1.67e-10 Axial length; LUSC cis rs1267303 0.636 rs1267310 chr1:46987307 A/T cg25110126 chr1:46999211 NA -0.56 -7.54 -0.38 4.58e-13 Monobrow; LUSC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg24675056 chr1:15929824 NA 0.46 7.92 0.4 3.44e-14 Systolic blood pressure; LUSC cis rs11690935 0.959 rs10206062 chr2:172577276 A/T cg13550731 chr2:172543902 DYNC1I2 -0.88 -14.75 -0.63 2.9e-38 Schizophrenia; LUSC cis rs6456156 0.586 rs9459862 chr6:167487011 A/G cg06454157 chr6:167490870 NA 0.26 6.41 0.33 5.05e-10 Primary biliary cholangitis; LUSC cis rs41271951 0.512 rs7537292 chr1:151071038 C/G cg11822372 chr1:151115635 SEMA6C -0.76 -6.95 -0.36 1.98e-11 Blood protein levels; LUSC cis rs4642101 0.512 rs12629892 chr3:12818920 A/G cg24848339 chr3:12840334 CAND2 0.35 7.88 0.4 4.52e-14 QRS complex (12-leadsum); LUSC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg13628971 chr7:2884303 GNA12 0.47 6.75 0.35 6.68e-11 Height; LUSC cis rs17270561 0.636 rs7754814 chr6:25745243 A/T cg17691542 chr6:26056736 HIST1H1C 0.55 7.79 0.39 8.71e-14 Iron status biomarkers; LUSC cis rs9788721 1.000 rs9788721 chr15:78802869 C/T cg18825076 chr15:78729989 IREB2 0.49 8.04 0.4 1.58e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs748404 0.660 rs694725 chr15:43756210 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.88 0.31 1.02e-8 Lung cancer; LUSC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4919694 1.000 rs11191445 chr10:104651055 C/T cg04362960 chr10:104952993 NT5C2 1.15 13.48 0.59 2.28e-33 Arsenic metabolism; LUSC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.2e-9 Menopause (age at onset); LUSC cis rs12893668 0.703 rs34896432 chr14:104027995 C/T cg01849466 chr14:104193079 ZFYVE21 -0.42 -5.74 -0.3 2.14e-8 Reticulocyte count; LUSC trans rs11098499 0.909 rs28632018 chr4:120386730 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.46 6.15 0.32 2.21e-9 Corneal astigmatism; LUSC cis rs61931739 0.517 rs11053063 chr12:34181011 C/T cg06521331 chr12:34319734 NA -0.45 -7.38 -0.37 1.29e-12 Morning vs. evening chronotype; LUSC cis rs11690935 1.000 rs35549875 chr2:172532392 A/G cg13550731 chr2:172543902 DYNC1I2 0.89 14.56 0.62 1.64e-37 Schizophrenia; LUSC cis rs939574 1.000 rs1024131 chr2:220117458 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 1.1 8.91 0.44 3.35e-17 Platelet distribution width; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg24813613 chr7:1882135 MAD1L1 -0.37 -6.15 -0.32 2.18e-9 Bipolar disorder and schizophrenia; LUSC cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg08999081 chr20:33150536 PIGU 0.52 10.36 0.49 5.48e-22 Glomerular filtration rate (creatinine); LUSC cis rs4786125 0.626 rs6500859 chr16:6914358 A/T cg03623568 chr16:6915990 A2BP1 -0.48 -8.02 -0.4 1.82e-14 Heart rate variability traits (SDNN); LUSC cis rs5769707 0.609 rs2071890 chr22:50001291 G/A cg20744362 chr22:50050164 C22orf34 0.37 7.02 0.36 1.22e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs7119 0.931 rs12901998 chr15:77833524 G/T cg27398640 chr15:77910606 LINGO1 -0.32 -7.22 -0.37 3.64e-12 Type 2 diabetes; LUSC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.91 -12.64 -0.57 3.31e-30 Platelet count; LUSC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg20090143 chr19:45452003 APOC2 0.47 9.37 0.46 1.08e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs56283067 0.847 rs12215181 chr6:44736076 C/T cg20913747 chr6:44695427 NA -0.5 -8.25 -0.41 3.77e-15 Total body bone mineral density; LUSC cis rs9611565 0.644 rs2413652 chr22:42097238 C/T cg17376030 chr22:41985996 PMM1 -0.43 -5.81 -0.3 1.45e-8 Vitiligo; LUSC cis rs7793919 0.764 rs6944865 chr7:4766383 A/T cg09789173 chr7:4769017 FOXK1 0.67 12.59 0.57 5.04e-30 Mosquito bite size; LUSC cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.84 -0.3 1.25e-8 Extrinsic epigenetic age acceleration; LUSC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg02475777 chr4:1388615 CRIPAK 0.4 5.89 0.31 9.36e-9 Obesity-related traits; LUSC cis rs2506889 0.553 rs17035189 chr1:10597024 A/G cg17425144 chr1:10567563 PEX14 0.65 13.6 0.6 7.83e-34 Breast cancer; LUSC cis rs11018904 0.861 rs12787117 chr11:89943681 A/G cg26834418 chr11:89957033 CHORDC1 -0.52 -6.21 -0.32 1.61e-9 Intelligence (multi-trait analysis); LUSC cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg03146154 chr1:46216737 IPP 0.51 7.57 0.38 3.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs156356 0.811 rs552067 chr20:1823326 C/G cg01434487 chr17:75953891 NA 0.4 6.02 0.31 4.71e-9 Mean platelet volume;Platelet distribution width; LUSC cis rs10193935 1.000 rs57883795 chr2:42387926 C/T cg27598129 chr2:42591480 NA -0.63 -8.15 -0.41 7.62e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs2836633 1.000 rs2836631 chr21:40065906 G/T cg05519781 chr21:40033154 ERG -0.61 -9.86 -0.47 2.63e-20 Coronary artery disease; LUSC cis rs983392 0.680 rs11230201 chr11:59996994 C/G cg24026212 chr11:59952134 MS4A6A -0.35 -6.1 -0.32 2.9e-9 Alzheimer's disease (late onset); LUSC cis rs9427116 0.840 rs9427114 chr1:154626705 T/C cg17218026 chr1:154582156 ADAR 0.5 8.5 0.42 6.3e-16 Blood protein levels; LUSC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg03233332 chr7:66118400 NA -0.41 -6.03 -0.31 4.27e-9 Aortic root size; LUSC cis rs7937682 0.575 rs11604704 chr11:111764396 G/A cg09085632 chr11:111637200 PPP2R1B 0.96 13.3 0.59 1.14e-32 Primary sclerosing cholangitis; LUSC cis rs1143633 0.579 rs4849132 chr2:113673471 G/A cg06156847 chr2:113672199 IL1F7 0.29 6.23 0.32 1.39e-9 Allergic disease (asthma, hay fever or eczema); LUSC trans rs6502050 0.835 rs7219138 chr17:80079896 C/T cg07393940 chr7:158741817 NA -0.37 -6.62 -0.34 1.46e-10 Life satisfaction; LUSC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.64 0.63 8.06e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg14440974 chr22:39074834 NA -0.36 -5.92 -0.31 7.79e-9 Menopause (age at onset); LUSC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg05855489 chr10:104503620 C10orf26 0.61 9.34 0.45 1.45e-18 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs10927875 0.632 rs10927863 chr1:16165247 C/A cg22431228 chr1:16359049 CLCNKA 0.33 6.33 0.33 7.8e-10 Dilated cardiomyopathy; LUSC cis rs7674212 0.537 rs2623060 chr4:104047504 G/A cg16532752 chr4:104119610 CENPE -0.49 -6.9 -0.35 2.66e-11 Type 2 diabetes; LUSC cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg06784218 chr1:46089804 CCDC17 0.48 9.48 0.46 4.93e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs11971779 0.584 rs6942519 chr7:139070090 A/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.69 10.71 0.51 3.24e-23 Monocyte percentage of white cells; LUSC cis rs713587 0.563 rs2033655 chr2:25101092 C/T cg15423357 chr2:25149977 NA 0.39 7.7 0.39 1.53e-13 Body mass index in non-asthmatics; LUSC cis rs13315871 0.790 rs13066409 chr3:58428444 A/G cg20936604 chr3:58311152 NA -0.71 -6.65 -0.34 1.16e-10 Cholesterol, total; LUSC trans rs11039798 0.588 rs113800184 chr11:48756855 G/A cg03929089 chr4:120376271 NA 0.66 7.34 0.37 1.6e-12 Axial length; LUSC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.69 -0.39 1.68e-13 Lymphocyte counts; LUSC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg05340658 chr4:99064831 C4orf37 0.65 11.15 0.52 9.29e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg04511125 chr2:88470314 THNSL2 0.97 9.55 0.46 2.87e-19 Plasma clusterin levels; LUSC cis rs8040855 0.579 rs4843029 chr15:85725395 A/G cg04831495 chr15:85060580 GOLGA6L5 0.41 6.87 0.35 3.1e-11 Bulimia nervosa; LUSC cis rs9325144 0.647 rs7980932 chr12:38921583 G/T cg26384229 chr12:38710491 ALG10B -0.6 -9.21 -0.45 3.72e-18 Morning vs. evening chronotype; LUSC cis rs1448094 0.836 rs6539935 chr12:86376809 T/C cg00310523 chr12:86230176 RASSF9 0.37 6.7 0.34 8.91e-11 Major depressive disorder; LUSC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC trans rs2490361 1.000 rs1024272 chr1:237320224 C/A cg15653282 chr18:11689218 GNAL 0.39 5.99 0.31 5.46e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs6845621 0.811 rs1990495 chr4:18932770 T/G cg12196642 chr4:18937545 NA -0.37 -6.88 -0.35 2.92e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs7917772 0.582 rs4917978 chr10:104366353 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.67 -11.16 -0.52 8.49e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg07701084 chr6:150067640 NUP43 0.55 8.55 0.42 4.62e-16 Lung cancer; LUSC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -6.11 -0.32 2.84e-9 Developmental language disorder (linguistic errors); LUSC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.4 -0.42 1.26e-15 Mean platelet volume; LUSC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg14668632 chr7:2872130 GNA12 -0.42 -5.95 -0.31 6.81e-9 Height; LUSC cis rs9611519 0.929 rs4820425 chr22:41431342 C/A cg03806693 chr22:41940476 POLR3H -0.5 -6.8 -0.35 4.74e-11 Neuroticism; LUSC cis rs9300255 0.568 rs1621194 chr12:123651018 T/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.14 -0.32 2.38e-9 Neutrophil percentage of white cells; LUSC cis rs4363385 0.776 rs3170863 chr1:152944594 C/T cg00922841 chr1:152955080 SPRR1A -0.44 -7.21 -0.37 3.72e-12 Inflammatory skin disease; LUSC cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs9420 0.754 rs631791 chr11:57675410 A/G cg23127183 chr11:57508653 C11orf31 0.47 5.68 0.3 2.96e-8 Schizophrenia; LUSC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg18876405 chr7:65276391 NA 0.58 9.59 0.46 2.21e-19 Aortic root size; LUSC cis rs829883 0.659 rs11109510 chr12:98911382 A/G cg25150519 chr12:98850993 NA -0.63 -8.61 -0.43 2.85e-16 Colorectal adenoma (advanced); LUSC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg12615879 chr12:58013172 SLC26A10 -0.26 -5.67 -0.3 3.05e-8 Multiple sclerosis; LUSC cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg05283184 chr6:79620031 NA -0.46 -8.75 -0.43 1.09e-16 Intelligence (multi-trait analysis); LUSC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg12826209 chr6:26865740 GUSBL1 0.74 9.08 0.44 9.64e-18 Intelligence (multi-trait analysis); LUSC cis rs6424115 0.708 rs2076343 chr1:24129126 A/G cg10978503 chr1:24200527 CNR2 -0.44 -9.08 -0.44 9.58e-18 Immature fraction of reticulocytes; LUSC cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg05347473 chr6:146136440 FBXO30 0.58 10.17 0.49 2.47e-21 Lobe attachment (rater-scored or self-reported); LUSC cis rs4919694 0.572 rs7080935 chr10:104929113 C/A cg04362960 chr10:104952993 NT5C2 0.91 11.51 0.53 4.9e-26 Arsenic metabolism; LUSC cis rs360798 0.512 rs6739804 chr2:63269604 T/C cg17519650 chr2:63277830 OTX1 0.58 8.24 0.41 3.87e-15 Coronary artery disease; LUSC cis rs13064411 0.696 rs1386336 chr3:113144153 C/T cg18753928 chr3:113234510 CCDC52 -0.49 -7.39 -0.37 1.2e-12 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg13010199 chr12:38710504 ALG10B -0.61 -10.43 -0.5 3.05e-22 Heart rate; LUSC cis rs7592578 0.508 rs62180987 chr2:191267173 A/G cg11845111 chr2:191398756 TMEM194B -0.67 -8.98 -0.44 1.98e-17 Diastolic blood pressure; LUSC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg01097406 chr16:89675127 NA -0.34 -6.58 -0.34 1.79e-10 Vitiligo; LUSC cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg03676636 chr4:99064102 C4orf37 0.36 8.04 0.4 1.54e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg20135002 chr11:47629003 NA -0.51 -8.11 -0.41 9.83e-15 Subjective well-being; LUSC cis rs1997103 0.906 rs4618644 chr7:55402037 T/G cg17469321 chr7:55412551 NA 0.66 10.63 0.5 6.09e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg04414720 chr1:150670196 GOLPH3L 0.54 8.42 0.42 1.15e-15 Melanoma; LUSC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg14019146 chr3:50243930 SLC38A3 0.32 7.08 0.36 8.39e-12 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg06637938 chr14:75390232 RPS6KL1 -0.5 -7.65 -0.39 2.1e-13 Height; LUSC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.64 -8.17 -0.41 6.31e-15 Glomerular filtration rate in chronic kidney disease; LUSC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.65 0.57 3.13e-30 Cognitive test performance; LUSC cis rs6005807 0.719 rs7289625 chr22:28896546 G/A cg12565055 chr22:29076175 TTC28 0.57 5.94 0.31 7.09e-9 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs939658 1.000 rs34286854 chr15:79454374 C/T cg17916960 chr15:79447300 NA -0.52 -10.38 -0.49 4.72e-22 Refractive error; LUSC cis rs17621444 0.505 rs10788018 chr10:121805260 T/G cg02041677 chr10:121771263 NA -0.34 -6.45 -0.33 3.88e-10 IgG glycosylation; LUSC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -5.83 -0.3 1.34e-8 Developmental language disorder (linguistic errors); LUSC cis rs763121 0.925 rs5750654 chr22:39051428 T/C cg06544989 chr22:39130855 UNC84B 0.35 6.28 0.32 1.06e-9 Menopause (age at onset); LUSC cis rs793571 0.523 rs7161889 chr15:58983425 C/G cg05156742 chr15:59063176 FAM63B 0.52 7.68 0.39 1.74e-13 Schizophrenia; LUSC cis rs12900413 0.603 rs11629982 chr15:90300272 G/A cg24249390 chr15:90295951 MESP1 -0.38 -5.96 -0.31 6.56e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs9303542 0.625 rs7222242 chr17:46565486 C/A cg09704116 chr17:46666958 LOC404266 -0.36 -6.17 -0.32 2.01e-9 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs950776 0.616 rs56276142 chr15:78889795 T/C cg06917634 chr15:78832804 PSMA4 0.75 13.18 0.59 3.05e-32 Sudden cardiac arrest; LUSC cis rs6681460 0.966 rs4655506 chr1:67150811 C/T cg02459107 chr1:67143332 SGIP1 0.46 8.73 0.43 1.21e-16 Presence of antiphospholipid antibodies; LUSC cis rs9354308 0.933 rs2814131 chr6:66562051 T/A cg07460842 chr6:66804631 NA 0.49 5.94 0.31 7.24e-9 Metabolite levels; LUSC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg05110241 chr16:68378359 PRMT7 -0.57 -6.52 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg14298792 chr15:30685198 CHRFAM7A 0.48 6.25 0.32 1.23e-9 Huntington's disease progression; LUSC cis rs4604732 0.631 rs1106721 chr1:247624676 A/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.57 7.78 0.39 9.24e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg08132940 chr7:1081526 C7orf50 -0.51 -5.93 -0.31 7.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg14895029 chr7:2775587 GNA12 -0.42 -6.29 -0.33 1.02e-9 Height; LUSC cis rs6089584 0.526 rs6089619 chr20:60610916 C/T cg13770153 chr20:60521292 NA -0.4 -5.66 -0.3 3.19e-8 Body mass index; LUSC cis rs1670533 0.872 rs11727136 chr4:1051804 G/A cg02018176 chr4:1364513 KIAA1530 0.46 6.33 0.33 7.73e-10 Recombination rate (females); LUSC cis rs2479724 0.935 rs1887718 chr6:41857691 C/T cg17623882 chr6:41773611 USP49 -0.63 -10.73 -0.51 2.72e-23 Menarche (age at onset); LUSC cis rs9311676 0.656 rs7642652 chr3:58373667 C/T cg13750441 chr3:58318267 PXK 0.36 6.93 0.35 2.12e-11 Systemic lupus erythematosus; LUSC cis rs4595586 0.525 rs17467376 chr12:39377551 T/G cg13010199 chr12:38710504 ALG10B 0.43 6.07 0.32 3.39e-9 Morning vs. evening chronotype; LUSC cis rs7980687 0.527 rs28533432 chr12:123873242 C/T cg00376283 chr12:123451042 ABCB9 0.7 9.88 0.48 2.29e-20 Height;Educational attainment;Head circumference (infant); LUSC cis rs9341835 0.709 rs4358600 chr6:64153219 G/A cg03326410 chr6:64151739 NA -0.38 -6.21 -0.32 1.59e-9 Schizophrenia; LUSC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg00255919 chr5:131827918 IRF1 0.43 8.28 0.41 3.11e-15 Asthma (sex interaction); LUSC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg13531842 chr10:38383804 ZNF37A -0.41 -6.38 -0.33 5.84e-10 Extrinsic epigenetic age acceleration; LUSC cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 8.03 0.4 1.64e-14 Axial length; LUSC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg22868518 chr11:507468 RNH1 -0.6 -5.94 -0.31 7.19e-9 Body mass index; LUSC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg06022373 chr22:39101656 GTPBP1 0.76 11.94 0.55 1.35e-27 Menopause (age at onset); LUSC cis rs1172822 0.665 rs897795 chr19:55831577 A/C cg04391588 chr19:55832610 TMEM150B 0.29 5.79 0.3 1.65e-8 Menarche and menopause (age at onset);Menopause (age at onset); LUSC cis rs7264396 0.832 rs224371 chr20:34074831 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.15 -0.32 2.23e-9 Total cholesterol levels; LUSC cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg11584989 chr19:19387371 SF4 0.59 7.02 0.36 1.22e-11 Bipolar disorder; LUSC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg07362569 chr17:61921086 SMARCD2 0.38 7.66 0.39 2.06e-13 Prudent dietary pattern; LUSC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg02527881 chr3:46936655 PTH1R -0.42 -7.56 -0.38 3.88e-13 Colorectal cancer; LUSC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg19748678 chr4:122722346 EXOSC9 -0.49 -7.74 -0.39 1.18e-13 Type 2 diabetes; LUSC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg23985595 chr17:80112537 CCDC57 0.31 5.88 0.31 9.82e-9 Life satisfaction; LUSC cis rs72781680 0.611 rs6720131 chr2:24364736 C/T cg06627628 chr2:24431161 ITSN2 -0.67 -8.03 -0.4 1.67e-14 Lymphocyte counts; LUSC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg16624210 chr5:671434 TPPP 0.49 6.1 0.32 2.89e-9 Lung disease severity in cystic fibrosis; LUSC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg04025307 chr7:1156635 C7orf50 0.43 5.92 0.31 8.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.7 11.19 0.52 6.48e-25 Prudent dietary pattern; LUSC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg11608241 chr8:8085544 FLJ10661 0.4 5.74 0.3 2.18e-8 Mood instability; LUSC cis rs1371867 0.810 rs1692004 chr8:101247320 T/C cg06636551 chr8:101224915 SPAG1 0.43 7.81 0.39 7.29e-14 Atrioventricular conduction; LUSC cis rs7267979 0.966 rs2424714 chr20:25418681 T/G cg08601574 chr20:25228251 PYGB 0.42 6.54 0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00881440 chr7:2595255 C7orf27 -0.42 -6.39 -0.33 5.46e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs853679 0.607 rs56189111 chr6:28271973 C/A cg01620082 chr3:125678407 NA -0.82 -7.68 -0.39 1.81e-13 Depression; LUSC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg21963583 chr11:68658836 MRPL21 0.57 8.5 0.42 6.54e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1670533 1.000 rs6836350 chr4:1069973 C/T cg02018176 chr4:1364513 KIAA1530 0.45 6.4 0.33 5.18e-10 Recombination rate (females); LUSC cis rs9303401 0.659 rs35797125 chr17:56736547 G/A cg25039879 chr17:56429692 SUPT4H1 0.64 8.67 0.43 1.92e-16 Cognitive test performance; LUSC cis rs56176327 0.532 rs9849038 chr3:49771990 A/G cg03060546 chr3:49711283 APEH 0.64 7.69 0.39 1.67e-13 Intelligence (multi-trait analysis); LUSC cis rs1670533 0.932 rs9992925 chr4:1050909 A/T cg16405210 chr4:1374714 KIAA1530 -0.46 -5.71 -0.3 2.44e-8 Recombination rate (females); LUSC cis rs61931739 1.000 rs12427391 chr12:34022891 A/G cg06521331 chr12:34319734 NA 0.39 6.49 0.33 3.14e-10 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs11053274 chr12:34547605 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.37 0.49 4.94e-22 Morning vs. evening chronotype; LUSC cis rs79911532 0.515 rs113244522 chr7:75715307 G/A cg03592824 chr7:75666768 STYXL1 0.67 6.42 0.33 4.79e-10 Mononucleosis; LUSC cis rs7267979 1.000 rs2424700 chr20:25266513 A/G cg08601574 chr20:25228251 PYGB 0.43 6.6 0.34 1.59e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs68170813 0.559 rs11769527 chr7:106912948 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.85e-20 Coronary artery disease; LUSC cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 12.33 0.56 4.97e-29 Chronic sinus infection; LUSC cis rs694739 0.857 rs574835 chr11:64110668 G/A cg02228329 chr11:64053129 BAD;GPR137 0.52 7.68 0.39 1.83e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs11098499 0.820 rs11737395 chr4:120520704 C/G cg24375607 chr4:120327624 NA 0.74 11.1 0.52 1.45e-24 Corneal astigmatism; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg27096981 chr4:124317819 SPRY1 0.38 6.09 0.32 3.06e-9 Schizophrenia; LUSC cis rs4911259 0.552 rs13041458 chr20:31467376 G/T cg13636640 chr20:31349939 DNMT3B -0.82 -15.9 -0.66 8.61e-43 Inflammatory bowel disease; LUSC cis rs6964587 0.541 rs6947170 chr7:91451471 A/G cg17063962 chr7:91808500 NA 0.53 8.62 0.43 2.73e-16 Breast cancer; LUSC cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC trans rs77236434 0.826 rs73562565 chr8:13179345 C/T cg05185040 chr8:41425077 NA -0.52 -5.95 -0.31 6.7e-9 Familial hepatitis B virus-related hepatocellular carcinoma; LUSC cis rs7809950 0.678 rs12672451 chr7:106853817 C/G cg23024343 chr7:107201750 COG5 -0.65 -9.08 -0.44 9.69e-18 Coronary artery disease; LUSC cis rs9434723 0.920 rs9434725 chr1:9293861 C/T cg04199779 chr1:9294473 H6PD 0.59 6.56 0.34 2.01e-10 Height; LUSC cis rs8170 0.603 rs8109328 chr19:17417955 C/T cg04749549 chr19:17459798 NA -0.32 -5.84 -0.3 1.24e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; LUSC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg07424592 chr7:64974309 NA 0.69 6.07 0.32 3.41e-9 Diabetic kidney disease; LUSC trans rs45509595 0.841 rs17751184 chr6:27775028 C/T cg06606381 chr12:133084897 FBRSL1 -1.0 -8.84 -0.44 5.76e-17 Breast cancer; LUSC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg15147215 chr3:52552868 STAB1 -0.31 -6.14 -0.32 2.3e-9 Bipolar disorder; LUSC cis rs8078723 0.802 rs9303283 chr17:38192633 A/G cg17467752 chr17:38218738 THRA 0.93 17.87 0.7 1.36e-50 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs981844 0.714 rs2405202 chr4:154705132 A/G cg14289246 chr4:154710475 SFRP2 -0.5 -7.04 -0.36 1.12e-11 Response to statins (LDL cholesterol change); LUSC cis rs13089785 1.000 rs2332682 chr3:123654633 C/T cg03892735 chr3:123506296 MYLK 0.33 5.65 0.3 3.43e-8 Intelligence (multi-trait analysis); LUSC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg05025164 chr4:1340916 KIAA1530 0.53 8.2 0.41 5.32e-15 Obesity-related traits; LUSC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg13393036 chr8:95962371 TP53INP1 -0.46 -9.49 -0.46 4.58e-19 Type 2 diabetes; LUSC cis rs10499694 0.901 rs6975453 chr7:50585211 A/T cg18232548 chr7:50535776 DDC -0.4 -5.78 -0.3 1.72e-8 Body mass index; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg10620100 chr15:40714174 NA 0.5 6.43 0.33 4.48e-10 Cognitive function;Information processing speed; LUSC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs7568458 0.684 rs7579147 chr2:85805654 G/A cg02493740 chr2:85810744 VAMP5 -0.52 -9.04 -0.44 1.34e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg05552183 chr6:42928497 GNMT 0.47 7.67 0.39 1.94e-13 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.48 -8.97 -0.44 2.14e-17 Monocyte percentage of white cells; LUSC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg00944433 chr1:107599041 PRMT6 0.35 6.56 0.34 2.03e-10 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs524023 1.000 rs524023 chr11:64358265 C/T cg07220939 chr11:64358617 SLC22A12 0.23 5.99 0.31 5.48e-9 Urate levels in obese individuals; LUSC cis rs354225 0.544 rs10169954 chr2:54808117 C/G cg26097391 chr2:54893211 SPTBN1 0.43 6.4 0.33 5.18e-10 Schizophrenia; LUSC cis rs7267979 0.932 rs449703 chr20:25458559 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.89 20.83 0.75 2.5e-62 Liver enzyme levels (alkaline phosphatase); LUSC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 7.21 0.37 3.73e-12 Mean platelet volume; LUSC trans rs2243480 1.000 rs73142121 chr7:65311206 C/T cg10756647 chr7:56101905 PSPH 0.87 8.43 0.42 1.06e-15 Diabetic kidney disease; LUSC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg01411255 chr17:61851458 DDX42;CCDC47 0.69 11.44 0.53 8.79e-26 Prudent dietary pattern; LUSC cis rs4253772 0.550 rs715515 chr22:46720921 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.62 6.17 0.32 1.93e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs800082 1.000 rs2717391 chr3:144279698 T/C cg24215973 chr2:240111563 HDAC4 0.47 6.98 0.36 1.59e-11 Smoking behavior; LUSC cis rs35000415 1.000 rs35000415 chr7:128585616 C/T cg19972273 chr7:128594194 NA 0.68 6.83 0.35 4.05e-11 Systemic lupus erythematosus; LUSC cis rs6121246 0.909 rs6087778 chr20:30354142 G/A cg13852791 chr20:30311386 BCL2L1 0.9 12.12 0.55 2.84e-28 Mean corpuscular hemoglobin; LUSC cis rs7659604 0.643 rs6838881 chr4:122663616 A/T cg19748678 chr4:122722346 EXOSC9 0.47 6.35 0.33 7.21e-10 Type 2 diabetes; LUSC cis rs7607369 0.536 rs13032993 chr2:219666377 T/C cg02176678 chr2:219576539 TTLL4 -0.51 -9.01 -0.44 1.57e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg18827107 chr12:86230957 RASSF9 -0.48 -7.26 -0.37 2.69e-12 Major depressive disorder; LUSC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2361710 1.000 rs2361710 chr17:78111877 C/T cg24585782 chr17:78113791 EIF4A3 0.37 5.93 0.31 7.43e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; LUSC cis rs11098499 0.691 rs12502524 chr4:120271414 G/A cg09307838 chr4:120376055 NA 0.62 9.47 0.46 5.25e-19 Corneal astigmatism; LUSC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03934478 chr11:495069 RNH1 0.9 10.31 0.49 8.19e-22 Body mass index; LUSC trans rs9354352 0.967 rs6455062 chr6:66694131 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.64 9.18 0.45 4.52e-18 Initial pursuit acceleration in psychotic disorders; LUSC cis rs55665837 0.961 rs11023226 chr11:14458817 C/T cg19336497 chr11:14380999 RRAS2 -0.37 -7.47 -0.38 6.93e-13 Vitamin D levels; LUSC cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg12310025 chr6:25882481 NA -0.35 -5.77 -0.3 1.79e-8 Height; LUSC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg12432903 chr7:1882776 MAD1L1 -0.39 -6.35 -0.33 7.01e-10 Bipolar disorder and schizophrenia; LUSC cis rs9831754 0.704 rs1512492 chr3:78471190 A/C cg06138941 chr3:78371609 NA -0.5 -6.75 -0.35 6.61e-11 Calcium levels; LUSC trans rs2898290 0.506 rs2736311 chr8:11252170 C/T cg06636001 chr8:8085503 FLJ10661 -0.4 -6.07 -0.32 3.5e-9 Systolic blood pressure; LUSC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs875971 0.660 rs10229345 chr7:65982168 G/C cg11764359 chr7:65958608 NA 0.64 9.66 0.47 1.23e-19 Aortic root size; LUSC cis rs2607426 0.681 rs2545760 chr19:41299824 G/A cg05508168 chr19:41255947 C19orf54;SNRPA 1.0 6.8 0.35 4.87e-11 Blood protein levels; LUSC cis rs8017423 0.967 rs11628812 chr14:90713720 G/T cg14092571 chr14:90743983 NA 0.37 5.97 0.31 6.09e-9 Mortality in heart failure; LUSC cis rs7927771 0.542 rs7102205 chr11:47745374 C/T cg20307385 chr11:47447363 PSMC3 0.44 6.32 0.33 8.42e-10 Subjective well-being; LUSC cis rs2290416 0.786 rs60401352 chr8:144673097 G/A cg26536354 chr8:144654954 C8orf73 0.65 7.23 0.37 3.27e-12 Attention deficit hyperactivity disorder; LUSC cis rs11676348 0.935 rs6716276 chr2:218962205 A/G cg00012203 chr2:219082015 ARPC2 -0.55 -8.54 -0.42 4.89e-16 Ulcerative colitis; LUSC cis rs372883 0.583 rs117214 chr21:30720834 A/G cg24692254 chr21:30365293 RNF160 0.52 7.7 0.39 1.6e-13 Pancreatic cancer; LUSC cis rs614226 0.872 rs787827 chr12:120937794 A/G cg21053147 chr12:120880522 NA -0.5 -6.16 -0.32 2.04e-9 Type 1 diabetes nephropathy; LUSC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg18099408 chr3:52552593 STAB1 -0.41 -7.02 -0.36 1.22e-11 Bipolar disorder; LUSC cis rs7772486 0.846 rs1474871 chr6:146406294 G/A cg23711669 chr6:146136114 FBXO30 0.82 14.48 0.62 3.37e-37 Lobe attachment (rater-scored or self-reported); LUSC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.48 6.44 0.33 4.18e-10 Tonsillectomy; LUSC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg02951883 chr7:2050386 MAD1L1 -0.47 -8.18 -0.41 5.88e-15 Bipolar disorder and schizophrenia; LUSC cis rs300703 0.542 rs189762 chr2:180079 A/T cg21211680 chr2:198530 NA -0.58 -7.03 -0.36 1.15e-11 Blood protein levels; LUSC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg14433983 chr11:636460 DRD4 -0.37 -6.01 -0.31 4.77e-9 Systemic lupus erythematosus; LUSC cis rs611744 0.806 rs2440387 chr8:109067078 A/G cg18478394 chr8:109455254 TTC35 0.43 6.32 0.33 8.49e-10 Dupuytren's disease; LUSC cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg04450456 chr4:17643702 FAM184B -0.43 -7.03 -0.36 1.17e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg22823121 chr1:150693482 HORMAD1 0.53 7.92 0.4 3.67e-14 Melanoma; LUSC cis rs977987 0.806 rs4887824 chr16:75441613 T/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.58 -0.34 1.79e-10 Dupuytren's disease; LUSC cis rs6754311 0.638 rs1011361 chr2:136553639 G/A cg25344623 chr2:136566232 LCT 0.38 5.75 0.3 2e-8 Mosquito bite size; LUSC cis rs9309473 0.848 rs9750915 chr2:73811880 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -6.61 -0.34 1.52e-10 Metabolite levels; LUSC cis rs636291 0.517 rs11121579 chr1:10541824 G/C cg17425144 chr1:10567563 PEX14 0.62 12.47 0.56 1.51e-29 Prostate cancer; LUSC trans rs895636 1.000 rs895636 chr2:45188353 A/G cg06568401 chr4:42089384 SLC30A9 0.4 6.04 0.31 4.02e-9 Metabolite levels;Fasting plasma glucose; LUSC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg24733560 chr20:60626293 TAF4 0.39 6.12 0.32 2.59e-9 Body mass index; LUSC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg18876405 chr7:65276391 NA 0.67 11.93 0.55 1.38e-27 Aortic root size; LUSC cis rs7659604 0.540 rs4075065 chr4:122683906 A/G cg19748678 chr4:122722346 EXOSC9 -0.4 -6.14 -0.32 2.29e-9 Type 2 diabetes; LUSC cis rs1211375 0.606 rs1203977 chr16:256278 A/C cg00126636 chr16:237282 NA 0.4 6.38 0.33 6.01e-10 Hematology traits;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs7100689 0.598 rs2342815 chr10:82086532 T/C cg01528321 chr10:82214614 TSPAN14 0.82 12.33 0.56 4.69e-29 Post bronchodilator FEV1; LUSC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg09455208 chr3:40491958 NA 0.58 9.9 0.48 2.03e-20 Renal cell carcinoma; LUSC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg24642439 chr20:33292090 TP53INP2 0.56 8.68 0.43 1.82e-16 Height; LUSC cis rs7188861 0.681 rs12598646 chr16:11406519 C/T cg00044050 chr16:11439710 C16orf75 0.56 6.27 0.32 1.14e-9 HDL cholesterol; LUSC cis rs6500395 0.963 rs12444902 chr16:48667126 G/T cg04672837 chr16:48644449 N4BP1 0.46 6.9 0.35 2.6e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs61931739 0.500 rs6416261 chr12:34540377 T/C cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.63 -9.91 -0.48 1.84e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2290416 0.584 rs3816477 chr8:144685271 T/C cg21187068 chr8:144659627 NAPRT1 -0.58 -7.59 -0.38 3.18e-13 Attention deficit hyperactivity disorder; LUSC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg26380479 chr7:97908229 NA -0.28 -6.26 -0.32 1.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7829975 0.514 rs2945873 chr8:8260445 C/T cg15556689 chr8:8085844 FLJ10661 0.67 11.41 0.53 1.12e-25 Mood instability; LUSC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg04025307 chr7:1156635 C7orf50 0.54 8.65 0.43 2.25e-16 Longevity;Endometriosis; LUSC cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg26378065 chr17:18585709 ZNF286B 0.47 6.95 0.36 1.91e-11 Educational attainment (years of education); LUSC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg16049864 chr8:95962084 TP53INP1 0.62 10.88 0.51 8.36e-24 Type 2 diabetes; LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.16 0.76 1.23e-63 Prudent dietary pattern; LUSC cis rs2050392 0.630 rs303426 chr10:30740379 A/G cg18806716 chr10:30721971 MAP3K8 0.44 7.01 0.36 1.31e-11 Inflammatory bowel disease; LUSC cis rs11586313 1.000 rs11586313 chr1:152890470 C/T cg07796016 chr1:152779584 LCE1C -0.55 -8.09 -0.4 1.14e-14 Vitamin D levels; LUSC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg06145435 chr7:1022769 CYP2W1 0.31 6.49 0.33 3.12e-10 Longevity;Endometriosis; LUSC trans rs11039798 0.536 rs112223280 chr11:48145077 C/G cg15704280 chr7:45808275 SEPT13 0.8 6.0 0.31 5.16e-9 Axial length; LUSC cis rs12464483 0.591 rs4952171 chr2:30886903 G/A cg12454169 chr2:30669597 LCLAT1 0.68 8.44 0.42 9.46e-16 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.82 -0.35 4.33e-11 Menopause (age at onset); LUSC cis rs3818717 0.538 rs12945601 chr17:17653411 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.45 7.02 0.36 1.28e-11 Lymphocyte counts; LUSC cis rs8038465 1.000 rs8032727 chr15:73977336 A/G cg15420318 chr15:73925796 NPTN 0.42 6.75 0.35 6.45e-11 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs8078723 1.000 rs4795415 chr17:38157995 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.82 -0.35 4.38e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC trans rs11098499 0.954 rs13107475 chr4:120393011 A/T cg25214090 chr10:38739885 LOC399744 0.57 8.4 0.42 1.3e-15 Corneal astigmatism; LUSC cis rs921968 0.643 rs492400 chr2:219349752 C/T cg02176678 chr2:219576539 TTLL4 0.61 11.19 0.52 6.73e-25 Mean corpuscular hemoglobin concentration; LUSC cis rs9905704 0.681 rs7211133 chr17:56558918 G/A cg19466818 chr17:56409534 MIR142 0.36 6.61 0.34 1.53e-10 Testicular germ cell tumor; LUSC cis rs9467773 0.836 rs1624440 chr6:26433329 G/A cg09904177 chr6:26538194 HMGN4 -0.65 -10.67 -0.5 4.69e-23 Intelligence (multi-trait analysis); LUSC cis rs356992 0.957 rs356993 chr2:60750560 C/T cg08426369 chr2:60753602 BCL11A -0.45 -6.25 -0.32 1.26e-9 Educational attainment (years of education); LUSC cis rs7188861 0.768 rs62023605 chr16:11380861 A/C cg00044050 chr16:11439710 C16orf75 0.56 6.31 0.33 8.71e-10 HDL cholesterol; LUSC cis rs7267979 0.932 rs367666 chr20:25449818 T/C cg08601574 chr20:25228251 PYGB 0.41 6.21 0.32 1.56e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9747201 1.000 rs3922470 chr17:80110159 C/T cg17462356 chr17:80056334 FASN 0.46 6.23 0.32 1.4e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs16976116 0.901 rs28433503 chr15:55499857 T/C cg11288833 chr15:55489084 RSL24D1 0.51 6.1 0.32 2.89e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs908922 1.000 rs1199150 chr1:152455602 T/C cg20991723 chr1:152506922 NA 0.5 8.78 0.43 8.68e-17 Hair morphology; LUSC cis rs897984 0.568 rs67456613 chr16:30888295 G/A cg02466173 chr16:30829666 NA -0.54 -8.7 -0.43 1.54e-16 Dementia with Lewy bodies; LUSC cis rs2012796 0.661 rs59969857 chr14:81841579 A/G cg02996355 chr14:81879375 NA 0.52 7.59 0.38 3.12e-13 Night sleep phenotypes; LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg00814883 chr7:100076585 TSC22D4 -0.76 -9.65 -0.47 1.35e-19 Platelet count; LUSC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg07716408 chr11:68623521 NA -0.34 -6.72 -0.35 7.85e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.35 5.71 0.3 2.47e-8 Self-reported allergy; LUSC cis rs1595825 0.891 rs7580003 chr2:198517893 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -5.75 -0.3 2.02e-8 Ulcerative colitis; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg03579872 chr1:53393473 SCP2 -0.39 -5.66 -0.3 3.31e-8 Monocyte count; LUSC cis rs909674 0.690 rs1972280 chr22:39831986 T/A cg01416388 chr22:39784598 NA -0.45 -6.96 -0.36 1.76e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg20896738 chr21:46707857 POFUT2;LOC642852 0.43 5.88 0.31 9.71e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg20845466 chr8:109260899 EIF3E 0.39 5.95 0.31 6.82e-9 Triglycerides; LUSC cis rs12618769 0.652 rs11896729 chr2:99225645 T/C cg10123293 chr2:99228465 UNC50 0.47 7.64 0.39 2.27e-13 Bipolar disorder; LUSC cis rs13392177 0.660 rs12988046 chr2:219073804 A/G cg00012203 chr2:219082015 ARPC2 -0.77 -13.07 -0.58 8.08e-32 Pyoderma gangrenosum in inflammatory bowel disease; LUSC trans rs1908814 0.516 rs11996277 chr8:11800031 G/A cg06636001 chr8:8085503 FLJ10661 0.53 7.87 0.4 5.04e-14 Neuroticism; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg09975850 chr8:65711396 CYP7B1 0.41 6.23 0.32 1.4e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.08 0.55 4.09e-28 Hip circumference adjusted for BMI; LUSC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.28e-9 Menopause (age at onset); LUSC cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg19077165 chr18:44547161 KATNAL2 -0.38 -5.8 -0.3 1.52e-8 Personality dimensions; LUSC cis rs1448094 0.933 rs10779218 chr12:86320053 A/G cg00310523 chr12:86230176 RASSF9 0.4 7.15 0.36 5.68e-12 Major depressive disorder; LUSC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg09035930 chr12:129282057 SLC15A4 0.66 13.27 0.59 1.4e-32 Systemic lupus erythematosus; LUSC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg21573476 chr21:45109991 RRP1B -0.4 -6.44 -0.33 4.13e-10 Mean corpuscular volume; LUSC cis rs1003719 0.591 rs2040125 chr21:38549236 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.77 0.39 9.95e-14 Eye color traits; LUSC cis rs2197308 0.606 rs12314897 chr12:38392293 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.35 -0.42 1.89e-15 Morning vs. evening chronotype; LUSC cis rs6964587 0.935 rs28412174 chr7:91577245 T/G cg22117172 chr7:91764530 CYP51A1 -0.32 -5.84 -0.3 1.24e-8 Breast cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02744793 chr10:35378717 CUL2 0.42 6.35 0.33 6.85e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4974559 0.690 rs28641665 chr4:1288781 G/T cg02980000 chr4:1222292 CTBP1 1.02 9.35 0.46 1.28e-18 Systolic blood pressure; LUSC cis rs189798 1.000 rs189798 chr8:8990577 A/G cg15556689 chr8:8085844 FLJ10661 -0.47 -6.59 -0.34 1.75e-10 Myopia (pathological); LUSC cis rs13031619 0.607 rs13011199 chr2:3694994 A/G cg19052272 chr2:3704530 ALLC 0.33 6.22 0.32 1.49e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg20476274 chr7:133979776 SLC35B4 0.88 16.9 0.68 1.01e-46 Mean platelet volume; LUSC cis rs6674970 0.933 rs12134957 chr1:151045419 A/G cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.44 -5.92 -0.31 8.01e-9 Childhood ear infection; LUSC cis rs3087591 0.664 rs2525565 chr17:29666588 T/C cg24425628 chr17:29625626 OMG;NF1 0.47 7.23 0.37 3.33e-12 Hip circumference; LUSC cis rs798554 0.616 rs1636251 chr7:2884720 T/C cg02423579 chr7:2872169 GNA12 -0.36 -5.75 -0.3 2.05e-8 Height; LUSC trans rs56114371 0.777 rs200483 chr6:27774824 C/T cg06606381 chr12:133084897 FBRSL1 -0.7 -7.47 -0.38 6.93e-13 Breast cancer; LUSC cis rs11098499 0.954 rs11734241 chr4:120416872 A/G cg09307838 chr4:120376055 NA 0.79 11.58 0.54 2.77e-26 Corneal astigmatism; LUSC cis rs950027 0.620 rs1719245 chr15:45623782 T/C cg26924012 chr15:45694286 SPATA5L1 0.76 11.56 0.53 3.15e-26 Response to fenofibrate (adiponectin levels); LUSC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg23630131 chr7:65973040 NA 0.2 5.72 0.3 2.4e-8 Aortic root size; LUSC cis rs11098499 0.866 rs12374352 chr4:120281977 C/T cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs7568458 0.905 rs10187424 chr2:85794297 T/C cg17127132 chr2:85788382 GGCX 0.47 7.56 0.38 3.95e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs11051970 0.636 rs2733705 chr12:32561564 T/C cg02745156 chr12:32552066 NA 0.37 6.82 0.35 4.3e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs5758659 1.000 rs134900 chr22:42683343 C/G cg15557168 chr22:42548783 NA -0.42 -7.14 -0.36 5.76e-12 Cognitive function; LUSC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg11062466 chr8:58055876 NA 0.68 7.72 0.39 1.33e-13 Developmental language disorder (linguistic errors); LUSC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg02951883 chr7:2050386 MAD1L1 -0.4 -6.85 -0.35 3.66e-11 Bipolar disorder and schizophrenia; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02732134 chr10:101732382 DNMBP -0.37 -6.13 -0.32 2.45e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1048238 0.506 rs12039892 chr1:16167974 A/G cg21385522 chr1:16154831 NA 0.58 8.73 0.43 1.23e-16 Systolic blood pressure; LUSC cis rs9650315 0.530 rs35399441 chr8:57089431 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.55 8.44 0.42 9.62e-16 Height; LUSC cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg20891558 chr2:74357851 NA 0.79 14.23 0.61 3.02e-36 Gestational age at birth (maternal effect); LUSC cis rs4144743 1.000 rs67923812 chr17:45326151 T/G cg18085866 chr17:45331354 ITGB3 -0.73 -7.69 -0.39 1.7e-13 Body mass index; LUSC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg18681998 chr4:17616180 MED28 0.84 15.64 0.65 9.06e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6495367 0.966 rs745029 chr15:79381779 C/T cg17916960 chr15:79447300 NA 0.36 6.74 0.35 6.95e-11 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.88 0.31 9.97e-9 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 13.83 0.6 1.06e-34 Platelet count; LUSC trans rs7944735 1.000 rs7944735 chr11:47955608 G/C cg15704280 chr7:45808275 SEPT13 0.64 6.65 0.34 1.18e-10 Intraocular pressure; LUSC trans rs877282 0.853 rs7083589 chr10:754494 G/A cg13042288 chr15:90349979 ANPEP -0.46 -6.42 -0.33 4.66e-10 Uric acid levels; LUSC trans rs6084875 0.840 rs1885357 chr20:4727427 G/A cg26257163 chr5:25190441 NA -0.36 -6.06 -0.31 3.62e-9 Systemic lupus erythematosus; LUSC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg22532475 chr10:104410764 TRIM8 -0.33 -7.32 -0.37 1.92e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs765787 0.530 rs2458224 chr15:45522130 T/C cg25801113 chr15:45476975 SHF 0.34 7.11 0.36 6.99e-12 Uric acid levels; LUSC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg08219700 chr8:58056026 NA 0.72 7.79 0.39 8.28e-14 Developmental language disorder (linguistic errors); LUSC cis rs9473147 0.516 rs9357546 chr6:47549495 C/T cg12968598 chr6:47444699 CD2AP 0.51 7.66 0.39 1.99e-13 Platelet distribution width;Mean platelet volume; LUSC cis rs662064 0.962 rs2781230 chr1:10563717 G/A cg20482658 chr1:10539492 PEX14 0.33 6.64 0.34 1.25e-10 Asthma; LUSC cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg23649088 chr2:200775458 C2orf69 -0.56 -6.69 -0.34 9.64e-11 Schizophrenia; LUSC cis rs728616 0.681 rs117420340 chr10:82166495 T/C cg05935833 chr10:81318306 SFTPA2 -0.45 -5.99 -0.31 5.43e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs870825 0.655 rs28555435 chr4:185647300 C/A cg04058563 chr4:185651563 MLF1IP 0.82 12.65 0.57 2.98e-30 Blood protein levels; LUSC cis rs9790314 0.586 rs16832279 chr3:161120483 C/T cg03342759 chr3:160939853 NMD3 -0.44 -6.83 -0.35 4.12e-11 Morning vs. evening chronotype; LUSC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Vitiligo; LUSC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg27284194 chr4:1044797 NA 0.37 6.04 0.31 4e-9 Longevity; LUSC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg24881330 chr22:46731750 TRMU 0.88 8.87 0.44 4.55e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg17366294 chr4:99064904 C4orf37 0.59 10.29 0.49 9.63e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs208520 1.000 rs208536 chr6:66963440 T/C cg07460842 chr6:66804631 NA -0.96 -12.45 -0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs9300255 0.544 rs1790123 chr12:123659542 C/T cg13010344 chr12:123464640 ARL6IP4 -0.53 -6.49 -0.33 3.15e-10 Neutrophil percentage of white cells; LUSC cis rs838147 0.505 rs1688264 chr19:49209560 T/G cg21064579 chr19:49206444 FUT2 0.46 8.66 0.43 2.07e-16 Dietary macronutrient intake; LUSC cis rs75920871 0.528 rs10466590 chr11:116894413 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.42 -0.33 4.57e-10 Subjective well-being; LUSC cis rs6546550 1.000 rs6546550 chr2:70038232 C/G cg02498382 chr2:70120550 SNRNP27 -0.3 -7.15 -0.36 5.56e-12 Prevalent atrial fibrillation; LUSC cis rs10751667 1.000 rs10794357 chr11:973374 T/C ch.11.42038R chr11:967971 AP2A2 0.55 8.31 0.41 2.41e-15 Alzheimer's disease (late onset); LUSC cis rs7582180 0.903 rs13031493 chr2:100896376 G/C cg08017756 chr2:100939284 LONRF2 -0.36 -6.01 -0.31 4.77e-9 Intelligence (multi-trait analysis); LUSC cis rs1443512 0.812 rs1561987 chr12:54335268 C/T cg25024717 chr12:54324583 NA -0.35 -5.92 -0.31 7.94e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs77741769 0.571 rs11065284 chr12:121266621 G/A cg02419362 chr12:121203948 SPPL3 0.45 8.49 0.42 6.8e-16 Mean corpuscular volume; LUSC cis rs478304 0.651 rs78412025 chr11:65495696 T/C cg05805236 chr11:65401703 PCNXL3 -0.57 -9.25 -0.45 2.79e-18 Acne (severe); LUSC cis rs6121246 0.909 rs4518038 chr20:30419051 A/G cg18721089 chr20:30220636 NA -0.37 -5.95 -0.31 6.7e-9 Mean corpuscular hemoglobin; LUSC cis rs1348850 0.597 rs13014512 chr2:178470851 T/A cg22681709 chr2:178499509 PDE11A -0.55 -8.07 -0.4 1.25e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg12756686 chr19:29218302 NA 0.59 6.86 0.35 3.26e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC trans rs2204008 0.837 rs11172728 chr12:38070042 C/A cg06521331 chr12:34319734 NA -0.41 -6.43 -0.33 4.33e-10 Bladder cancer; LUSC cis rs67072384 1.000 rs72964185 chr11:72443177 G/A cg04827223 chr11:72435913 ARAP1 -0.83 -7.37 -0.37 1.38e-12 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC trans rs1814175 0.817 rs28525029 chr11:50045815 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -25.08 -0.81 8.21e-79 Height; LUSC cis rs10864907 0.614 rs7557537 chr2:113702530 T/C cg06156847 chr2:113672199 IL1F7 -0.28 -5.83 -0.3 1.32e-8 Pulmonary function; LUSC cis rs6733011 0.500 rs10182043 chr2:99417433 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.51 -6.6 -0.34 1.59e-10 Bipolar disorder; LUSC trans rs459571 0.920 rs455073 chr9:136909141 G/C cg10765909 chr12:53715428 AAAS -0.42 -5.98 -0.31 5.77e-9 Platelet distribution width; LUSC cis rs10949662 1.000 rs10949662 chr7:157534105 A/G cg11757124 chr7:157526947 PTPRN2 0.44 6.66 0.34 1.13e-10 Intelligence (multi-trait analysis); LUSC cis rs34779708 0.966 rs1213392 chr10:35430285 C/T cg03585969 chr10:35415529 CREM 0.59 8.88 0.44 4.28e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg03146154 chr1:46216737 IPP 0.53 7.79 0.39 8.71e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg20135002 chr11:47629003 NA -0.43 -6.96 -0.36 1.85e-11 Subjective well-being; LUSC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.44 -0.33 4.08e-10 Alzheimer's disease (late onset); LUSC cis rs7615316 0.510 rs7630115 chr3:142210801 C/T cg16271453 chr3:142027066 XRN1 -0.52 -9.21 -0.45 3.66e-18 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs17767294 0.708 rs72847370 chr6:27849424 A/T cg23539494 chr17:65276751 NA 0.74 6.11 0.32 2.7e-9 Parkinson's disease; LUSC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.78 -9.8 -0.47 4.12e-20 Gut microbiome composition (summer); LUSC cis rs611744 0.647 rs631775 chr8:109252746 T/C cg18478394 chr8:109455254 TTC35 0.42 6.42 0.33 4.79e-10 Dupuytren's disease; LUSC cis rs6570726 0.526 rs9376934 chr6:145738702 A/G cg23711669 chr6:146136114 FBXO30 0.55 8.38 0.42 1.45e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927592 0.913 rs3758643 chr11:68367193 C/T cg16797656 chr11:68205561 LRP5 0.37 6.09 0.32 3.15e-9 Total body bone mineral density; LUSC trans rs800082 0.501 rs9844730 chr3:144216886 T/G cg24215973 chr2:240111563 HDAC4 0.49 7.4 0.38 1.12e-12 Smoking behavior; LUSC cis rs9329289 1.000 rs9329289 chr10:2542389 A/G cg05625103 chr10:2543513 NA 0.37 5.78 0.3 1.74e-8 Age-related hearing impairment; LUSC trans rs6601327 0.641 rs4129360 chr8:9573284 T/A cg15556689 chr8:8085844 FLJ10661 -0.44 -6.29 -0.33 1e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs11971779 0.680 rs4732370 chr7:139077240 A/C cg23387468 chr7:139079360 LUC7L2 -0.41 -6.25 -0.32 1.25e-9 Diisocyanate-induced asthma; LUSC cis rs6961069 0.585 rs1761663 chr7:80239418 T/C cg04458919 chr7:80252533 CD36 -0.4 -7.32 -0.37 1.91e-12 Platelet count; LUSC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg05872129 chr22:39784769 NA -0.6 -11.01 -0.52 3.01e-24 Intelligence (multi-trait analysis); LUSC cis rs2227564 0.597 rs2271271 chr10:75558867 G/A cg23231163 chr10:75533350 FUT11 -0.45 -6.57 -0.34 1.91e-10 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12908161 1.000 rs35726233 chr15:85337800 C/T cg17507749 chr15:85114479 UBE2QP1 0.53 6.54 0.34 2.25e-10 Schizophrenia; LUSC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg07716408 chr11:68623521 NA -0.31 -5.96 -0.31 6.55e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs17621444 0.522 rs4322307 chr10:121777328 C/T cg02041677 chr10:121771263 NA -0.34 -6.37 -0.33 6.41e-10 IgG glycosylation; LUSC cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg01028140 chr2:1542097 TPO -0.61 -8.06 -0.4 1.36e-14 Placebo response in major depressive disorder (% change in symptom score); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09428623 chr2:68480128 PPP3R1 0.5 7.02 0.36 1.27e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4594175 0.926 rs10138269 chr14:51615360 T/C cg23942311 chr14:51606299 NA 0.31 6.07 0.32 3.39e-9 Cancer; LUSC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 9.61 0.47 1.81e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg02527881 chr3:46936655 PTH1R -0.4 -7.08 -0.36 8.71e-12 Colorectal cancer; LUSC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg10802521 chr3:52805072 NEK4 -0.58 -9.1 -0.45 8.23e-18 Bipolar disorder; LUSC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.03 15.14 0.64 8.96e-40 Platelet count; LUSC cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg16405210 chr4:1374714 KIAA1530 -0.85 -13.94 -0.61 3.89e-35 Longevity; LUSC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg03709012 chr19:19516395 GATAD2A 0.84 14.17 0.61 5.3e-36 Tonsillectomy; LUSC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg13683864 chr3:40499215 RPL14 -1.12 -20.04 -0.74 3.17e-59 Renal cell carcinoma; LUSC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg11050988 chr7:1952600 MAD1L1 -0.31 -5.95 -0.31 6.8e-9 Bipolar disorder and schizophrenia; LUSC trans rs62140779 0.778 rs17049584 chr2:58828331 C/G cg20220755 chr7:142012034 NA 0.39 5.99 0.31 5.43e-9 Neuroticism; LUSC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg18099408 chr3:52552593 STAB1 -0.42 -7.36 -0.37 1.45e-12 Bipolar disorder; LUSC cis rs12188164 0.932 rs2230437 chr5:476353 C/T cg21972741 chr5:435613 AHRR 0.34 6.35 0.33 7.01e-10 Cystic fibrosis severity; LUSC cis rs11098499 0.865 rs28845498 chr4:120405186 G/A cg09307838 chr4:120376055 NA 0.77 11.37 0.53 1.57e-25 Corneal astigmatism; LUSC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 7.89 0.4 4.28e-14 Bipolar disorder; LUSC cis rs3770081 1.000 rs12622009 chr2:86248325 T/C cg23655155 chr2:86332777 POLR1A;PTCD3 -0.78 -5.68 -0.3 3e-8 Facial emotion recognition (sad faces); LUSC cis rs7296418 0.663 rs11057284 chr12:123830692 G/C cg05973401 chr12:123451056 ABCB9 0.54 7.93 0.4 3.24e-14 Platelet count; LUSC cis rs240764 0.853 rs12206945 chr6:101018032 C/T cg09795085 chr6:101329169 ASCC3 0.42 6.14 0.32 2.29e-9 Neuroticism; LUSC trans rs453301 0.624 rs330049 chr8:9087299 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.77 0.35 5.95e-11 Joint mobility (Beighton score); LUSC cis rs6752107 0.901 rs2289477 chr2:234160345 T/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.71 11.91 0.55 1.74e-27 Crohn's disease;Inflammatory bowel disease; LUSC cis rs11270836 1 rs11270836 chr4:38625915 T/TACATTATGTCATTTCACA cg18361445 chr4:38666374 KLF3;FLJ13197 0.57 8.4 0.42 1.33e-15 Mumps; LUSC cis rs897984 0.542 rs8061047 chr16:31068960 T/C cg02466173 chr16:30829666 NA -0.5 -9.46 -0.46 5.63e-19 Dementia with Lewy bodies; LUSC cis rs6693567 0.526 rs698918 chr1:150319762 A/G cg15654264 chr1:150340011 RPRD2 0.44 7.02 0.36 1.22e-11 Migraine; LUSC cis rs9393692 0.905 rs9357004 chr6:26303319 A/G cg00631329 chr6:26305371 NA -0.47 -9.48 -0.46 4.98e-19 Educational attainment; LUSC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg15468180 chr1:107600409 PRMT6 0.36 5.86 0.31 1.13e-8 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg07716408 chr11:68623521 NA -0.3 -5.67 -0.3 3.16e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs12908161 1.000 rs12903134 chr15:85337699 T/A cg17507749 chr15:85114479 UBE2QP1 0.53 6.59 0.34 1.71e-10 Schizophrenia; LUSC cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg24642439 chr20:33292090 TP53INP2 0.49 7.42 0.38 9.86e-13 Glomerular filtration rate (creatinine); LUSC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg11764359 chr7:65958608 NA -0.69 -10.39 -0.49 4.28e-22 Aortic root size; LUSC cis rs1443512 0.588 rs1975473 chr12:54334625 G/A cg17410650 chr12:54324560 NA -0.46 -6.16 -0.32 2.12e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg22823121 chr1:150693482 HORMAD1 0.51 7.54 0.38 4.49e-13 Melanoma; LUSC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg07507251 chr3:52567010 NT5DC2 0.39 7.23 0.37 3.36e-12 Bipolar disorder; LUSC cis rs7617773 0.746 rs4130995 chr3:48358255 C/T cg11946769 chr3:48343235 NME6 0.76 11.77 0.54 5.7e-27 Coronary artery disease; LUSC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg20135002 chr11:47629003 NA -0.5 -7.82 -0.39 6.92e-14 Subjective well-being; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21910613 chr1:27191950 NA 0.42 6.1 0.32 2.98e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg04998671 chr14:104000505 TRMT61A -0.42 -5.92 -0.31 8.01e-9 Reticulocyte count; LUSC trans rs853679 0.882 rs9393908 chr6:28190830 T/A cg06606381 chr12:133084897 FBRSL1 -0.66 -6.94 -0.36 2.05e-11 Depression; LUSC cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg13010199 chr12:38710504 ALG10B 0.66 9.92 0.48 1.69e-20 Bladder cancer; LUSC cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg16586182 chr3:47516702 SCAP -0.51 -7.2 -0.37 4.03e-12 Birth weight; LUSC cis rs4319547 0.695 rs7969429 chr12:122875606 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.42 -0.42 1.12e-15 Body mass index; LUSC cis rs4654899 0.802 rs9651021 chr1:21222770 A/C cg01072550 chr1:21505969 NA -0.48 -6.94 -0.36 2.04e-11 Superior frontal gyrus grey matter volume; LUSC cis rs7107174 1.000 rs2510040 chr11:77944548 T/A cg02023728 chr11:77925099 USP35 0.48 6.6 0.34 1.59e-10 Testicular germ cell tumor; LUSC cis rs11630290 0.604 rs17775820 chr15:64168582 G/A cg12036633 chr15:63758958 NA -0.64 -7.53 -0.38 4.66e-13 Iris characteristics; LUSC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.92 0.44 3.19e-17 Prudent dietary pattern; LUSC cis rs11030122 0.702 rs7128762 chr11:3943277 C/G cg18678763 chr11:4115507 RRM1 -0.45 -5.72 -0.3 2.37e-8 Mean platelet volume;Platelet distribution width; LUSC cis rs2046867 0.862 rs11920131 chr3:72858630 C/G cg25664220 chr3:72788482 NA -0.71 -12.06 -0.55 4.87e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg21862992 chr11:68658383 NA 0.52 8.13 0.41 8.72e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1982963 0.572 rs61971549 chr14:52478541 A/G cg10843707 chr14:52510701 NID2 0.42 5.93 0.31 7.76e-9 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg08219700 chr8:58056026 NA 0.64 8.16 0.41 6.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7605827 0.930 rs1024869 chr2:15549043 G/C cg19274914 chr2:15703543 NA 0.47 9.12 0.45 7e-18 Educational attainment (years of education); LUSC cis rs950169 0.922 rs4586394 chr15:84822385 G/A cg17173187 chr15:85201210 NMB -0.38 -6.89 -0.35 2.87e-11 Schizophrenia; LUSC cis rs72634258 0.786 rs7523335 chr1:8180210 G/A cg00042356 chr1:8021962 PARK7 0.54 6.59 0.34 1.72e-10 Inflammatory bowel disease; LUSC cis rs80130819 0.748 rs2732440 chr12:48660429 G/A cg24011408 chr12:48396354 COL2A1 0.46 5.84 0.3 1.22e-8 Prostate cancer; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg16451525 chr16:89167282 ACSF3 -0.38 -6.01 -0.31 4.99e-9 Asthma; LUSC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.86 0.35 3.37e-11 Intelligence (multi-trait analysis); LUSC cis rs4925114 0.568 rs9900803 chr17:17650978 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.5 -7.59 -0.38 3.23e-13 Body mass index; LUSC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg10295955 chr4:187884368 NA -1.08 -24.85 -0.81 6.31e-78 Lobe attachment (rater-scored or self-reported); LUSC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg05861140 chr6:150128134 PCMT1 0.42 6.68 0.34 1.01e-10 Lung cancer; LUSC cis rs1832871 0.683 rs56197409 chr6:158684338 A/G cg07165851 chr6:158734300 TULP4 0.51 7.81 0.39 7.24e-14 Height; LUSC cis rs4975709 0.838 rs4975753 chr5:1880865 T/C cg20790798 chr5:1857306 NA -0.39 -5.78 -0.3 1.76e-8 Cardiovascular disease risk factors; LUSC cis rs9815354 0.812 rs73830516 chr3:41876056 A/G cg03022575 chr3:42003672 ULK4 0.85 8.87 0.44 4.46e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs796364 0.806 rs78037592 chr2:201105734 G/T cg23649088 chr2:200775458 C2orf69 -0.61 -7.08 -0.36 8.8e-12 Schizophrenia; LUSC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg13770153 chr20:60521292 NA -0.67 -9.58 -0.46 2.31e-19 Body mass index; LUSC cis rs11785400 0.793 rs4581034 chr8:143736968 G/A cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg13319975 chr6:146136371 FBXO30 0.5 7.43 0.38 9e-13 Lobe attachment (rater-scored or self-reported); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg09796886 chr4:39640558 C4orf34 -0.46 -6.11 -0.32 2.72e-9 Bipolar disorder and schizophrenia; LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.72 -11.87 -0.54 2.37e-27 Prudent dietary pattern; LUSC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg00166722 chr3:10149974 C3orf24 0.59 8.16 0.41 6.95e-15 Alzheimer's disease; LUSC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg18512352 chr11:47633146 NA -0.47 -9.32 -0.45 1.62e-18 Subjective well-being; LUSC cis rs4253772 0.872 rs45576140 chr22:46638216 C/G cg18190219 chr22:46762943 CELSR1 -0.48 -5.81 -0.3 1.45e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs10203711 1.000 rs6707795 chr2:239555580 T/C cg14580085 chr2:239553406 NA 0.41 6.99 0.36 1.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs61931739 0.500 rs11053260 chr12:34530215 T/G cg06521331 chr12:34319734 NA -0.42 -6.85 -0.35 3.63e-11 Morning vs. evening chronotype; LUSC cis rs9788682 1.000 rs34138960 chr15:78831668 A/G cg06917634 chr15:78832804 PSMA4 -0.59 -7.17 -0.37 4.85e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs1865721 0.771 rs6566092 chr18:73136496 C/T cg26385618 chr18:73139727 C18orf62 -0.55 -10.1 -0.48 4.25e-21 Intelligence; LUSC cis rs10992471 0.603 rs11788523 chr9:95256593 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.77 -0.39 9.98e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02726883 chr17:29421732 NF1 0.44 6.77 0.35 5.91e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12894936 1 rs12894936 chr14:100846991 T/C cg14882082 chr14:100845427 WDR25 0.39 7.83 0.39 6.61e-14 Menarche (age at onset); LUSC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg16414030 chr3:133502952 NA 0.42 6.7 0.34 8.92e-11 Iron status biomarkers; LUSC cis rs7241530 0.662 rs12456683 chr18:75909031 C/T cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg18132916 chr6:79620363 NA -0.37 -5.65 -0.3 3.53e-8 Intelligence (multi-trait analysis); LUSC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg12311346 chr5:56204834 C5orf35 -0.88 -12.75 -0.57 1.35e-30 Initial pursuit acceleration; LUSC trans rs931812 0.757 rs4734492 chr8:101901901 C/T cg20993868 chr7:22813445 NA -0.5 -9.57 -0.46 2.43e-19 Attention deficit hyperactivity disorder and conduct disorder; LUSC cis rs4891159 0.790 rs4891161 chr18:74142683 A/G cg24786174 chr18:74118243 ZNF516 -0.91 -18.74 -0.72 4.5e-54 Longevity; LUSC cis rs7568458 0.905 rs17026396 chr2:85759127 C/T cg17127132 chr2:85788382 GGCX -0.47 -7.61 -0.38 2.77e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs3806843 0.966 rs10053945 chr5:140160127 C/T cg19875535 chr5:140030758 IK 0.47 7.66 0.39 2.01e-13 Depressive symptoms (multi-trait analysis); LUSC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg18099408 chr3:52552593 STAB1 -0.43 -7.5 -0.38 5.86e-13 Intelligence (multi-trait analysis); LUSC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg08975724 chr8:8085496 FLJ10661 0.52 7.92 0.4 3.61e-14 Mood instability; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg20314438 chr6:126661369 C6orf173 0.52 7.23 0.37 3.35e-12 Cognitive function;Information processing speed; LUSC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg03676636 chr4:99064102 C4orf37 0.34 7.33 0.37 1.8e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs12421382 0.683 rs10789735 chr11:109431361 A/T cg16359550 chr11:109292809 C11orf87 0.41 6.76 0.35 6.24e-11 Schizophrenia; LUSC cis rs6456156 0.603 rs2345754 chr6:167484361 T/C cg25258033 chr6:167368657 RNASET2 0.38 5.82 0.3 1.38e-8 Primary biliary cholangitis; LUSC cis rs16910800 1.000 rs16910794 chr11:23202631 A/T cg20040320 chr11:23191996 NA -0.44 -6.35 -0.33 6.87e-10 Cancer; LUSC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg26677194 chr12:130822605 PIWIL1 0.6 8.96 0.44 2.29e-17 Menopause (age at onset); LUSC cis rs2742234 0.541 rs10793424 chr10:43717116 G/T cg02780029 chr10:43622663 RET 0.35 5.82 0.3 1.41e-8 Hirschsprung disease; LUSC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg14552801 chr7:65878734 NA -0.45 -6.34 -0.33 7.34e-10 Aortic root size; LUSC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg21433558 chr17:40837037 CNTNAP1 0.36 6.2 0.32 1.69e-9 Colorectal or endometrial cancer; LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg25036284 chr2:26402008 FAM59B -0.74 -10.73 -0.51 2.89e-23 Gut microbiome composition (summer); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03648631 chr4:103749307 UBE2D3 0.39 6.06 0.31 3.57e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs909674 0.734 rs5757675 chr22:39838892 G/T cg02038168 chr22:39784481 NA -0.43 -6.47 -0.33 3.47e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; LUSC cis rs9479482 0.686 rs2184452 chr6:150384827 T/C cg25797454 chr6:150327115 RAET1K 0.29 6.26 0.32 1.18e-9 Alopecia areata; LUSC cis rs2274273 0.714 rs7154889 chr14:55806885 G/A cg04306507 chr14:55594613 LGALS3 0.56 13.13 0.58 4.79e-32 Protein biomarker; LUSC cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg00530320 chr1:46809349 NSUN4 0.56 8.69 0.43 1.68e-16 Menopause (age at onset); LUSC cis rs454953 0.533 rs211436 chr6:133612992 A/G cg22462983 chr6:133561756 EYA4 -0.41 -5.9 -0.31 8.7e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg08219700 chr8:58056026 NA 0.53 6.83 0.35 4.05e-11 Developmental language disorder (linguistic errors); LUSC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg09165964 chr15:75287851 SCAMP5 0.52 7.61 0.38 2.87e-13 Breast cancer; LUSC cis rs9325144 0.671 rs7485963 chr12:38768254 C/G cg13010199 chr12:38710504 ALG10B -0.5 -7.49 -0.38 6.05e-13 Morning vs. evening chronotype; LUSC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg03929089 chr4:120376271 NA -0.78 -12.33 -0.56 4.92e-29 Height; LUSC cis rs243505 0.559 rs1558420 chr7:148480114 G/T cg09806900 chr7:148480153 CUL1 0.67 9.96 0.48 1.21e-20 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7824557 0.564 rs4631424 chr8:11236809 T/C cg27411982 chr8:10470053 RP1L1 -0.37 -5.79 -0.3 1.63e-8 Retinal vascular caliber; LUSC cis rs859767 0.741 rs4954159 chr2:135426782 A/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.04 -0.31 4.1e-9 Neuroticism; LUSC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg11812906 chr14:75593930 NEK9 -0.62 -10.32 -0.49 7.47e-22 Height; LUSC cis rs12791968 0.659 rs12808379 chr11:45009273 C/G cg11846598 chr11:44996168 LOC221122 -0.56 -7.78 -0.39 9.2e-14 Inhibitory control; LUSC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.93 12.99 0.58 1.61e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2898290 0.622 rs1382567 chr8:11350899 T/C cg08975724 chr8:8085496 FLJ10661 -0.41 -6.12 -0.32 2.6e-9 Systolic blood pressure; LUSC cis rs1348850 0.668 rs6734426 chr2:178493770 C/T cg23306229 chr2:178417860 TTC30B 0.5 5.82 0.3 1.36e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg09904177 chr6:26538194 HMGN4 -0.42 -6.22 -0.32 1.49e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg01689657 chr7:91764605 CYP51A1 0.32 5.84 0.3 1.27e-8 Breast cancer; LUSC cis rs17270561 0.583 rs6926425 chr6:25785304 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 6.55 0.34 2.18e-10 Iron status biomarkers; LUSC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg08564027 chr20:61660810 NA 0.9 17.3 0.69 2.61e-48 Prostate cancer (SNP x SNP interaction); LUSC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg21548813 chr6:291882 DUSP22 -0.71 -11.89 -0.55 1.96e-27 Menopause (age at onset); LUSC cis rs889512 0.642 rs3826110 chr16:75277780 G/A cg04987608 chr16:75300043 BCAR1 -0.49 -5.69 -0.3 2.84e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs908922 0.676 rs493133 chr1:152493875 G/C cg20991723 chr1:152506922 NA 0.54 10.18 0.49 2.18e-21 Hair morphology; LUSC cis rs9399135 0.935 rs949547 chr6:135343499 C/G cg24558204 chr6:135376177 HBS1L 0.59 9.28 0.45 2.26e-18 Red blood cell count; LUSC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11644478 chr21:40555479 PSMG1 0.93 18.05 0.7 2.67e-51 Cognitive function; LUSC cis rs16912285 0.688 rs59797575 chr11:24315536 A/T ch.11.24196551F chr11:24239977 NA 0.89 9.47 0.46 5.22e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs3862030 0.720 rs11191295 chr10:104231054 A/G cg05855489 chr10:104503620 C10orf26 0.49 7.36 0.37 1.48e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs10170310 1.000 rs10170310 chr2:139278922 C/T cg10095539 chr2:139258744 SPOPL 0.3 5.81 0.3 1.47e-8 Response to antipsychotic treatment; LUSC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg18765753 chr7:1198926 ZFAND2A -0.49 -8.75 -0.43 1.09e-16 Longevity;Endometriosis; LUSC cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.87 -0.35 3.22e-11 Monocyte percentage of white cells; LUSC cis rs4713675 0.584 rs3227 chr6:33662295 G/C cg14003231 chr6:33640908 ITPR3 0.31 6.04 0.31 4.12e-9 Plateletcrit; LUSC trans rs4252134 0.881 rs4252076 chr6:161128922 A/G cg00639886 chr12:54943102 PDE1B -0.43 -6.33 -0.33 7.68e-10 Giant cell arteritis; LUSC cis rs2880765 0.835 rs28874135 chr15:86031503 G/A cg13263323 chr15:86062960 AKAP13 -0.35 -5.73 -0.3 2.3e-8 Coronary artery disease; LUSC cis rs225245 0.755 rs6505493 chr17:34028901 A/G cg05299278 chr17:33885742 SLFN14 0.3 6.55 0.34 2.14e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC trans rs7826238 0.720 rs12546760 chr8:8374836 A/G cg21775007 chr8:11205619 TDH -0.42 -6.09 -0.32 3.16e-9 Systolic blood pressure; LUSC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs6960043 0.818 rs10238161 chr7:15053827 A/T cg19272540 chr7:15055459 NA 0.35 8.69 0.43 1.6e-16 Type 2 diabetes; LUSC cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg01884057 chr2:25150051 NA 0.48 11.39 0.53 1.29e-25 Body mass index; LUSC cis rs11216435 0.512 rs2276343 chr11:117375596 G/A cg27161313 chr11:117392002 DSCAML1 -0.41 -7.02 -0.36 1.25e-11 Menarche (age at onset); LUSC cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.67 -0.3 3.17e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.61 6.28 0.32 1.08e-9 Initial pursuit acceleration; LUSC cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg00353675 chr12:132601362 EP400NL -0.41 -6.38 -0.33 5.76e-10 N-glycan levels; LUSC cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs78579285 0.583 rs1061238 chr16:88781850 A/G cg01900006 chr16:88814613 FAM38A -0.54 -6.12 -0.32 2.69e-9 Joint mobility (Beighton score); LUSC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg22857025 chr5:266934 NA -1.15 -16.58 -0.67 1.82e-45 Breast cancer; LUSC cis rs6456156 0.819 rs9457273 chr6:167520749 A/T cg07741184 chr6:167504864 NA -0.35 -6.02 -0.31 4.69e-9 Primary biliary cholangitis; LUSC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg25072359 chr17:41440525 NA 0.58 8.51 0.42 6.11e-16 Menopause (age at onset); LUSC cis rs977987 0.835 rs11641532 chr16:75329480 T/C cg04384234 chr16:75411784 CFDP1 -0.4 -6.48 -0.33 3.35e-10 Dupuytren's disease; LUSC cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg11244672 chr19:19639970 YJEFN3 -0.59 -7.33 -0.37 1.7e-12 Bipolar disorder; LUSC trans rs7824557 0.815 rs2736372 chr8:11106041 T/C cg15556689 chr8:8085844 FLJ10661 -0.53 -8.2 -0.41 5.09e-15 Retinal vascular caliber; LUSC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg07716408 chr11:68623521 NA -0.32 -6.19 -0.32 1.8e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg00814883 chr7:100076585 TSC22D4 -0.74 -10.01 -0.48 8.51e-21 Platelet count; LUSC trans rs1941687 0.510 rs1452649 chr18:31410858 A/G cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs10779751 0.959 rs2300091 chr1:11266711 C/T cg08854313 chr1:11322531 MTOR 0.91 16.32 0.67 1.93e-44 Body mass index; LUSC cis rs62400317 0.859 rs12199871 chr6:45307682 C/T cg18551225 chr6:44695536 NA -0.45 -7.44 -0.38 8.72e-13 Total body bone mineral density; LUSC cis rs4595586 0.545 rs7970850 chr12:39397878 T/C cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs143985986 1 rs143985986 chr3:58399886 TC/T cg13750441 chr3:58318267 PXK 0.34 6.52 0.34 2.57e-10 Hematocrit; LUSC cis rs11792861 0.781 rs2151426 chr9:111743797 A/C cg13535736 chr9:111863775 C9orf5 -0.38 -5.88 -0.31 1e-8 Menarche (age at onset); LUSC cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg25382214 chr1:3105252 PRDM16 -0.3 -5.89 -0.31 9.52e-9 Migraine; LUSC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg13939156 chr17:80058883 NA -0.33 -6.46 -0.33 3.6e-10 Life satisfaction; LUSC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 12.32 0.56 5.33e-29 Cognitive test performance; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg22920501 chr2:26401640 FAM59B 0.82 12.42 0.56 2.16e-29 Gut microbiome composition (summer); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22198946 chr2:43454609 ZFP36L2;LOC100129726 -0.41 -6.18 -0.32 1.89e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg23788917 chr6:8435910 SLC35B3 0.49 7.3 0.37 2.13e-12 Motion sickness; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16082737 chr14:58711570 PSMA3 -0.44 -6.96 -0.36 1.76e-11 Electrocardiographic conduction measures; LUSC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 6.21 0.32 1.62e-9 Schizophrenia; LUSC cis rs6546550 0.901 rs6716937 chr2:70127229 G/A cg02498382 chr2:70120550 SNRNP27 -0.3 -7.39 -0.37 1.2e-12 Prevalent atrial fibrillation; LUSC cis rs7953508 0.741 rs1498706 chr12:93996980 C/T cg18151635 chr12:93972918 NA -0.41 -5.72 -0.3 2.38e-8 Pubertal anthropometrics; LUSC cis rs4808199 0.843 rs10402308 chr19:19657500 G/A cg03709012 chr19:19516395 GATAD2A 1.02 13.63 0.6 5.9e-34 Nonalcoholic fatty liver disease; LUSC cis rs9309473 0.898 rs10185080 chr2:73797507 C/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.77 -0.35 5.8200000000000003e-11 Metabolite levels; LUSC cis rs1865760 0.713 rs7766342 chr6:25990674 C/A cg17691542 chr6:26056736 HIST1H1C 0.47 7.04 0.36 1.08e-11 Height; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg19432297 chr22:26908626 TFIP11 -0.47 -6.25 -0.32 1.27e-9 Hepatitis; LUSC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg13206674 chr6:150067644 NUP43 0.5 7.68 0.39 1.75e-13 Lung cancer; LUSC cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg06784218 chr1:46089804 CCDC17 0.47 9.15 0.45 5.94e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg13628971 chr7:2884303 GNA12 0.43 6.39 0.33 5.5e-10 Height; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg16944159 chr2:62132759 COMMD1 0.42 6.5 0.34 2.96e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs1994135 0.617 rs10844642 chr12:33730368 A/C cg06521331 chr12:34319734 NA -0.41 -6.06 -0.31 3.68e-9 Resting heart rate; LUSC cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg18252515 chr7:66147081 NA -1.23 -13.78 -0.6 1.62e-34 Diabetic kidney disease; LUSC cis rs1008375 0.843 rs59112113 chr4:17685336 A/T cg04450456 chr4:17643702 FAM184B 0.41 6.93 0.35 2.2e-11 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg11494091 chr17:61959527 GH2 0.64 13.56 0.6 1.12e-33 Prudent dietary pattern; LUSC cis rs77216612 0.877 rs7956514 chr12:12879254 T/G cg09462578 chr12:12878428 APOLD1 -1.0 -17.09 -0.68 1.76e-47 Lymphocyte counts; LUSC cis rs453301 0.686 rs6601280 chr8:8909236 A/T cg15556689 chr8:8085844 FLJ10661 0.59 8.38 0.42 1.45e-15 Joint mobility (Beighton score); LUSC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg07701084 chr6:150067640 NUP43 0.58 8.97 0.44 2.22e-17 Lung cancer; LUSC cis rs9815354 1.000 rs28733681 chr3:41863444 C/A cg03022575 chr3:42003672 ULK4 0.58 6.54 0.34 2.3e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs9653442 0.564 rs11123809 chr2:100758137 C/T cg07810366 chr2:100720526 AFF3 -0.43 -7.24 -0.37 3.03e-12 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg25251562 chr2:3704773 ALLC 0.63 10.43 0.5 3.16e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.36 -7.5 -0.38 5.64e-13 Hemoglobin concentration; LUSC trans rs6502050 0.731 rs9892653 chr17:80100191 G/T cg07393940 chr7:158741817 NA 0.35 6.28 0.32 1.06e-9 Life satisfaction; LUSC trans rs8073060 0.586 rs8077826 chr17:34001139 G/A cg19694781 chr19:47549865 TMEM160 -1.14 -18.19 -0.71 7.14e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.59 -7.95 -0.4 2.82e-14 Renal function-related traits (BUN); LUSC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12756686 chr19:29218302 NA 0.68 10.05 0.48 6.36e-21 Methadone dose in opioid dependence; LUSC cis rs4704187 0.687 rs1422698 chr5:74443132 C/T cg03227963 chr5:74354835 NA 0.31 6.78 0.35 5.45e-11 Response to amphetamines; LUSC cis rs478304 0.903 rs495961 chr11:65540886 C/T cg08755490 chr11:65554678 OVOL1 0.41 5.88 0.31 9.7e-9 Acne (severe); LUSC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.67 0.43 1.91e-16 Prudent dietary pattern; LUSC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg09655341 chr17:79618100 PDE6G -0.29 -6.73 -0.35 7.21e-11 Eye color traits; LUSC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg05855489 chr10:104503620 C10orf26 0.54 7.86 0.4 5.41e-14 Arsenic metabolism; LUSC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.62 8.91 0.44 3.47e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs7824557 0.564 rs55758514 chr8:11230259 A/T cg21775007 chr8:11205619 TDH -0.68 -10.92 -0.51 6.24e-24 Retinal vascular caliber; LUSC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.83 13.4 0.59 4.43e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs28374715 0.662 rs28827035 chr15:41492290 G/A cg18705301 chr15:41695430 NDUFAF1 -0.86 -15.14 -0.64 9.02e-40 Ulcerative colitis; LUSC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg00074818 chr8:8560427 CLDN23 0.58 9.66 0.47 1.23e-19 Obesity-related traits; LUSC cis rs7712401 0.601 rs2910136 chr5:122254017 C/T cg19077854 chr5:122220652 SNX24 -0.41 -9.16 -0.45 5.32e-18 Mean platelet volume; LUSC cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg23788917 chr6:8435910 SLC35B3 0.49 7.47 0.38 7.01e-13 Motion sickness; LUSC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg11764359 chr7:65958608 NA 0.52 6.85 0.35 3.5e-11 Aortic root size; LUSC cis rs6736093 1.000 rs34928784 chr2:112657062 G/C cg12686935 chr2:112915763 FBLN7 -0.4 -6.14 -0.32 2.3e-9 Coronary artery disease; LUSC cis rs1348850 0.757 rs4893954 chr2:178340520 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.36 0.37 1.43e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC trans rs4942242 1.000 rs9533566 chr13:44224691 T/C cg19169023 chr15:41853346 TYRO3 -0.45 -7.29 -0.37 2.31e-12 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs877282 0.891 rs12767043 chr10:797943 C/T cg13042288 chr15:90349979 ANPEP -0.5 -7.06 -0.36 9.79e-12 Uric acid levels; LUSC cis rs7296418 0.922 rs12425009 chr12:123502044 C/T cg05973401 chr12:123451056 ABCB9 0.64 9.38 0.46 1.04e-18 Platelet count; LUSC cis rs757081 0.702 rs522619 chr11:17204448 A/G cg15432903 chr11:17409602 KCNJ11 -0.38 -5.85 -0.3 1.18e-8 Systolic blood pressure; LUSC cis rs3741151 0.686 rs7112924 chr11:73106408 C/T cg17517138 chr11:73019481 ARHGEF17 0.89 8.4 0.42 1.31e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg02569458 chr12:86230093 RASSF9 -0.47 -7.86 -0.4 5.3e-14 Major depressive disorder; LUSC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg18404041 chr3:52824283 ITIH1 -0.62 -12.25 -0.56 9.44e-29 Bipolar disorder; LUSC cis rs6714788 0.523 rs6542905 chr2:100654707 C/G cg22139774 chr2:100720529 AFF3 -0.38 -6.04 -0.31 4.2e-9 Intelligence (multi-trait analysis); LUSC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg01585723 chr16:33734837 NA 0.45 7.51 0.38 5.58e-13 Menopause (age at onset); LUSC cis rs6696846 0.749 rs11578293 chr1:205070178 T/C cg21545522 chr1:205238299 TMCC2 0.43 8.2 0.41 5.33e-15 Red blood cell count; LUSC cis rs1559088 0.847 rs3760891 chr19:33599708 C/T cg03563238 chr19:33554763 RHPN2 -0.4 -6.43 -0.33 4.3e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs6951245 0.638 rs4720486 chr7:1146764 G/A cg13565492 chr6:43139072 SRF -0.72 -10.66 -0.5 4.91e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9318086 0.624 rs9510909 chr13:24436760 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.43 6.41 0.33 5.09e-10 Myopia (pathological); LUSC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg11366901 chr6:160182831 ACAT2 0.91 12.24 0.56 1.04e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg23887609 chr12:130822674 PIWIL1 0.49 7.26 0.37 2.68e-12 Menopause (age at onset); LUSC cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.68 -8.8 -0.43 7.34e-17 Chronic sinus infection; LUSC cis rs7264396 0.887 rs58458373 chr20:34045611 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.71 -0.34 8.33e-11 Total cholesterol levels; LUSC cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg06671706 chr8:8559999 CLDN23 0.49 6.57 0.34 1.94e-10 Obesity-related traits; LUSC cis rs4132509 0.793 rs4478795 chr1:243844576 C/T cg21452805 chr1:244014465 NA 0.65 6.9 0.35 2.64e-11 RR interval (heart rate); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg24009358 chr15:66797395 ZWILCH;RPL4 -0.51 -6.95 -0.36 1.94e-11 Hepatitis; LUSC cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg06784218 chr1:46089804 CCDC17 0.55 11.17 0.52 7.69e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs7980687 0.628 rs1727332 chr12:123718301 C/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.35 -6.38 -0.33 5.75e-10 Height;Educational attainment;Head circumference (infant); LUSC cis rs2898290 0.622 rs1478890 chr8:11355602 C/G cg21775007 chr8:11205619 TDH -0.49 -7.27 -0.37 2.5e-12 Systolic blood pressure; LUSC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.19 -0.45 4.42e-18 Gut microbiome composition (summer); LUSC cis rs2955259 0.735 rs2955260 chr4:170874986 T/C cg19918862 chr4:170955249 NA -0.33 -6.33 -0.33 7.9e-10 Educational attainment; LUSC cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -7.06 -0.36 9.9e-12 Menarche (age at onset); LUSC cis rs11039100 1.000 rs12798822 chr11:5826711 T/C cg05234568 chr11:5960015 NA -0.5 -5.71 -0.3 2.47e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs1728785 0.792 rs1111502 chr16:68581209 A/G cg02508848 chr16:68573721 ZFP90 -0.42 -5.72 -0.3 2.41e-8 Ulcerative colitis; LUSC cis rs7605827 0.930 rs12692260 chr2:15511809 A/G cg19274914 chr2:15703543 NA 0.46 8.95 0.44 2.45e-17 Educational attainment (years of education); LUSC cis rs6696846 0.905 rs11240349 chr1:205041015 G/A cg21545522 chr1:205238299 TMCC2 0.46 8.38 0.42 1.53e-15 Red blood cell count; LUSC cis rs7617773 0.780 rs11718350 chr3:48360992 T/G cg11946769 chr3:48343235 NME6 0.89 14.17 0.61 5.1e-36 Coronary artery disease; LUSC cis rs7681440 0.874 rs1372525 chr4:90776165 G/A cg15133208 chr4:90757351 SNCA -0.32 -5.66 -0.3 3.23e-8 Dementia with Lewy bodies; LUSC cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.77 -0.3 1.82e-8 Extrinsic epigenetic age acceleration; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18776286 chr10:52383679 SGMS1 -0.42 -6.36 -0.33 6.76e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs983392 0.642 rs636147 chr11:59957092 C/T cg20284999 chr11:59952153 MS4A6A 0.36 6.25 0.32 1.28e-9 Alzheimer's disease (late onset); LUSC cis rs782590 0.935 rs782649 chr2:55860308 T/C cg18811423 chr2:55921094 PNPT1 0.83 14.56 0.62 1.62e-37 Metabolic syndrome; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg13047869 chr3:10149882 C3orf24 0.66 9.19 0.45 4.17e-18 Alzheimer's disease; LUSC cis rs4356932 0.691 rs7436021 chr4:76905472 A/G cg00809888 chr4:76862425 NAAA 0.37 5.88 0.31 9.75e-9 Blood protein levels; LUSC cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg18681998 chr4:17616180 MED28 0.85 15.45 0.65 5.32e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.64 11.56 0.53 3.14e-26 Menopause (age at onset); LUSC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg22800045 chr5:56110881 MAP3K1 0.79 10.53 0.5 1.45e-22 Initial pursuit acceleration; LUSC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg11764359 chr7:65958608 NA -0.78 -12.7 -0.57 2.07e-30 Aortic root size; LUSC trans rs60843830 1.000 rs17713396 chr2:227201 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.53 0.46 3.28e-19 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg04944784 chr2:26401820 FAM59B -0.68 -9.42 -0.46 7.58e-19 Gut microbiome composition (summer); LUSC trans rs61931739 0.500 rs12146843 chr12:34451738 T/G cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.32e-18 Morning vs. evening chronotype; LUSC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg06634786 chr22:41940651 POLR3H -0.54 -6.63 -0.34 1.34e-10 Vitiligo; LUSC cis rs1858037 0.836 rs17475335 chr2:65605780 G/C cg08085232 chr2:65598271 SPRED2 -0.43 -6.43 -0.33 4.4e-10 Rheumatoid arthritis; LUSC cis rs8028313 0.630 rs12438118 chr15:67951150 A/C cg24579218 chr15:68104479 NA 0.4 7.01 0.36 1.32e-11 Obesity; LUSC cis rs6424115 1.000 rs12121387 chr1:24166536 T/G cg15997130 chr1:24165203 NA -0.52 -8.61 -0.43 2.88e-16 Immature fraction of reticulocytes; LUSC cis rs427943 0.639 rs2838820 chr21:46646005 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.42 6.16 0.32 2.1e-9 Body mass index; LUSC cis rs782590 0.902 rs782601 chr2:55848244 T/C cg03859395 chr2:55845619 SMEK2 0.81 14.82 0.63 1.47e-38 Metabolic syndrome; LUSC cis rs11630290 0.736 rs7174738 chr15:64144813 A/T cg12036633 chr15:63758958 NA -0.6 -6.92 -0.35 2.37e-11 Iris characteristics; LUSC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg03526776 chr6:41159608 TREML2 0.33 6.44 0.33 4.24e-10 Alzheimer's disease (late onset); LUSC cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 12.86 0.58 5.11e-31 Chronic sinus infection; LUSC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg07150166 chr2:30669952 LCLAT1 0.87 7.66 0.39 2.08e-13 Midgestational circulating levels of PBDEs (fetal genetic effect); LUSC cis rs7572644 0.640 rs9678336 chr2:28065404 A/G cg27432699 chr2:27873401 GPN1 0.52 6.95 0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs5770917 1.000 rs2073605 chr22:51008850 A/G cg00270625 chr22:51017019 CPT1B;CHKB-CPT1B -0.62 -5.72 -0.3 2.42e-8 Narcolepsy; LUSC cis rs1538970 1.000 rs4660852 chr1:45848931 A/C cg06784218 chr1:46089804 CCDC17 -0.33 -6.12 -0.32 2.69e-9 Platelet count; LUSC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 12.4 0.56 2.61e-29 Prudent dietary pattern; LUSC cis rs10752881 1.000 rs10737235 chr1:182971816 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 10.52 0.5 1.49e-22 Colorectal cancer; LUSC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg08219700 chr8:58056026 NA 0.66 8.63 0.43 2.6e-16 Developmental language disorder (linguistic errors); LUSC cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg12927641 chr6:109611667 NA -0.36 -6.18 -0.32 1.83e-9 Reticulocyte fraction of red cells; LUSC cis rs2762353 0.526 rs12215823 chr6:25726074 G/C cg16482183 chr6:26056742 HIST1H1C 0.43 6.19 0.32 1.79e-9 Blood metabolite levels; LUSC cis rs939574 0.790 rs72955452 chr2:220101783 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.92 6.33 0.33 7.88e-10 Platelet distribution width; LUSC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.52 6.75 0.35 6.48e-11 Age-related macular degeneration (geographic atrophy); LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.51 -0.34 2.75e-10 Calcium levels; LUSC cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg08085267 chr17:45401833 C17orf57 -0.51 -7.95 -0.4 2.86e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7246657 0.943 rs10405407 chr19:37839164 C/T cg23950597 chr19:37808831 NA -0.63 -7.8 -0.39 8.08e-14 Coronary artery calcification; LUSC cis rs3774749 0.565 rs2518795 chr3:50208819 C/T cg24110177 chr3:50126178 RBM5 -0.4 -6.14 -0.32 2.39e-9 Intelligence (multi-trait analysis); LUSC cis rs75229567 0.618 rs11177853 chr12:70184924 A/G cg10114359 chr12:70132523 RAB3IP 1.46 13.11 0.58 5.71e-32 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs4751006 0.543 rs2890130 chr10:128783848 T/C cg05702161 chr10:128779687 DOCK1 -0.77 -6.29 -0.33 1.02e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs7826238 0.509 rs2948288 chr8:8115304 A/G cg06636001 chr8:8085503 FLJ10661 0.85 14.88 0.63 8.65e-39 Systolic blood pressure; LUSC cis rs9303401 0.614 rs2007993 chr17:56590643 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.84 12.51 0.56 1.01e-29 Cognitive test performance; LUSC cis rs9443189 0.570 rs7765254 chr6:76398143 T/C cg01950844 chr6:76311363 SENP6 0.64 5.97 0.31 6.19e-9 Prostate cancer; LUSC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.93 13.17 0.58 3.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg05855489 chr10:104503620 C10orf26 -0.67 -9.93 -0.48 1.62e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs861020 0.630 rs9308411 chr1:210005713 C/T cg05527609 chr1:210001259 C1orf107 0.67 9.88 0.48 2.31e-20 Orofacial clefts; LUSC trans rs208520 0.690 rs1738970 chr6:66809491 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.12 -17.6 -0.69 1.56e-49 Exhaled nitric oxide output; LUSC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.28 -0.45 2.26e-18 Gut microbiome composition (summer); LUSC cis rs3772130 0.962 rs4280673 chr3:121526107 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.21 0.49 1.78e-21 Cognitive performance; LUSC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg25726756 chr21:47582351 C21orf56 -0.34 -5.72 -0.3 2.33e-8 Testicular germ cell tumor; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg19178362 chr17:57233047 PRR11;SKA2 0.4 6.36 0.33 6.49e-10 Schizophrenia; LUSC cis rs8114671 0.527 rs6060112 chr20:33489276 A/T cg08999081 chr20:33150536 PIGU 0.33 5.76 0.3 1.87e-8 Height; LUSC cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg27446573 chr6:127587934 RNF146 0.91 15.09 0.64 1.31e-39 Breast cancer; LUSC trans rs804280 0.509 rs4841639 chr8:11796093 A/T cg15556689 chr8:8085844 FLJ10661 0.57 8.64 0.43 2.35e-16 Myopia (pathological); LUSC cis rs765787 0.530 rs10851423 chr15:45515950 G/A cg25801113 chr15:45476975 SHF -0.32 -6.45 -0.33 3.89e-10 Uric acid levels; LUSC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg08499158 chr17:42289980 UBTF 0.42 6.49 0.33 3.15e-10 Total body bone mineral density; LUSC cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg23711669 chr6:146136114 FBXO30 0.82 14.21 0.61 3.51e-36 Lobe attachment (rater-scored or self-reported); LUSC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg00033643 chr7:134001901 SLC35B4 0.45 7.02 0.36 1.24e-11 Mean platelet volume; LUSC cis rs6543140 0.964 rs7561351 chr2:103077780 A/G cg09003973 chr2:102972529 NA 0.55 7.04 0.36 1.09e-11 Blood protein levels; LUSC cis rs12760731 0.669 rs10798609 chr1:178431648 C/T cg00404053 chr1:178313656 RASAL2 0.55 6.27 0.32 1.13e-9 Obesity-related traits; LUSC cis rs9467773 0.869 rs9295689 chr6:26455811 T/C cg05738196 chr6:26577821 NA 0.64 10.43 0.5 3.19e-22 Intelligence (multi-trait analysis); LUSC trans rs1941687 0.797 rs12963804 chr18:31391208 T/C cg27147174 chr7:100797783 AP1S1 -0.45 -6.56 -0.34 2.04e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs6693567 0.545 rs4451552 chr1:150455854 C/G cg15654264 chr1:150340011 RPRD2 0.37 6.0 0.31 5.01e-9 Migraine; LUSC cis rs4820539 0.966 rs3788350 chr22:23468468 C/T cg21100191 chr22:23484243 RTDR1 0.87 14.38 0.62 7.77e-37 Bone mineral density; LUSC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg08470875 chr2:26401718 FAM59B -0.67 -8.89 -0.44 3.8e-17 Gut microbiome composition (summer); LUSC cis rs9399135 0.967 rs12527707 chr6:135324511 G/A cg22676075 chr6:135203613 NA 0.48 7.51 0.38 5.47e-13 Red blood cell count; LUSC cis rs1982963 0.572 rs61971550 chr14:52478669 T/G cg10843707 chr14:52510701 NID2 0.41 5.74 0.3 2.12e-8 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12760731 0.668 rs10913532 chr1:178278692 A/G cg00404053 chr1:178313656 RASAL2 0.5 6.08 0.32 3.29e-9 Obesity-related traits; LUSC trans rs6600671 1.000 rs6600669 chr1:121213639 G/C cg00646200 chr1:148855367 NA 0.45 7.05 0.36 1.02e-11 Hip geometry; LUSC cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 8.26 0.41 3.5e-15 Axial length; LUSC trans rs1499614 0.901 rs2178742 chr7:66197799 G/A cg10756647 chr7:56101905 PSPH 0.87 8.67 0.43 1.86e-16 Gout; LUSC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg00684032 chr4:1343700 KIAA1530 0.37 6.47 0.33 3.48e-10 Obesity-related traits; LUSC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg16584290 chr5:462447 EXOC3 0.45 8.09 0.4 1.1e-14 Cystic fibrosis severity; LUSC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg10556349 chr10:835070 NA 0.55 6.21 0.32 1.53e-9 Eosinophil percentage of granulocytes; LUSC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg17376030 chr22:41985996 PMM1 -0.47 -5.94 -0.31 7.32e-9 Vitiligo; LUSC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg06808227 chr14:105710500 BRF1 0.66 10.18 0.49 2.25e-21 Mean platelet volume;Platelet distribution width; LUSC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.61 0.38 2.76e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs2204008 0.540 rs1672425 chr12:38122842 G/A cg13010199 chr12:38710504 ALG10B -0.54 -8.14 -0.41 7.74e-15 Bladder cancer; LUSC cis rs6445967 0.689 rs11714574 chr3:58380465 A/T cg13750441 chr3:58318267 PXK -0.29 -5.91 -0.31 8.42e-9 Platelet count; LUSC cis rs61931739 0.500 rs11053197 chr12:34441949 C/T cg06521331 chr12:34319734 NA -0.4 -6.3 -0.33 9.13e-10 Morning vs. evening chronotype; LUSC cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg12011299 chr4:100065546 ADH4 -0.7 -10.73 -0.51 2.85e-23 Alcohol dependence; LUSC cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg21573476 chr21:45109991 RRP1B -0.39 -6.49 -0.33 3.11e-10 Mean corpuscular volume; LUSC cis rs950169 0.545 rs4354897 chr15:84644971 T/C cg12863693 chr15:85201151 NMB 0.32 6.07 0.32 3.38e-9 Schizophrenia; LUSC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg04455712 chr21:45112962 RRP1B 0.47 9.13 0.45 6.65e-18 Mean corpuscular volume; LUSC cis rs7818345 0.649 rs13250181 chr8:19328766 G/A cg11303988 chr8:19266685 CSGALNACT1 0.34 6.05 0.31 3.79e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6977660 1.000 rs5017194 chr7:19820035 A/T cg05791153 chr7:19748676 TWISTNB 0.53 5.81 0.3 1.42e-8 Thyroid stimulating hormone; LUSC cis rs9443645 0.810 rs7753531 chr6:79789996 A/C cg09184832 chr6:79620586 NA -0.37 -5.84 -0.3 1.24e-8 Intelligence (multi-trait analysis); LUSC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg09238746 chr17:78121135 EIF4A3 -0.6 -8.98 -0.44 1.97e-17 Yeast infection; LUSC cis rs2073300 1.000 rs6114101 chr20:23446322 C/T cg09953122 chr20:23471693 CST8 -0.79 -6.82 -0.35 4.29e-11 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12134245 0.874 rs17501937 chr1:92021705 C/T cg21854759 chr1:92012499 NA 0.41 6.59 0.34 1.72e-10 Breast cancer; LUSC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.28 6.03 0.31 4.33e-9 Electroencephalogram traits; LUSC cis rs7809950 0.954 rs3779494 chr7:107250355 G/A cg23024343 chr7:107201750 COG5 0.56 8.77 0.43 9.03e-17 Coronary artery disease; LUSC cis rs7605827 0.866 rs2287275 chr2:15658828 C/T cg19274914 chr2:15703543 NA 0.46 8.86 0.44 4.96e-17 Educational attainment (years of education); LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.94 0.31 7.2e-9 Menopause (age at onset); LUSC cis rs7264396 0.635 rs6058355 chr20:34491343 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.85 -0.44 5.17e-17 Total cholesterol levels; LUSC cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg06784218 chr1:46089804 CCDC17 0.55 11.21 0.52 5.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4268898 0.662 rs714531 chr2:24399877 G/A cg06627628 chr2:24431161 ITSN2 -0.86 -12.1 -0.55 3.46e-28 Asthma; LUSC cis rs2777491 0.872 rs7163649 chr15:41586798 A/G cg18705301 chr15:41695430 NDUFAF1 -0.75 -14.52 -0.62 2.16e-37 Ulcerative colitis; LUSC trans rs10098647 0.632 rs72663286 chr8:61106074 T/C cg09970348 chr3:183978600 ECE2;CAMK2N2 0.44 5.96 0.31 6.54e-9 Obesity-related traits; LUSC cis rs11785400 0.762 rs7017931 chr8:143726728 A/G cg24634471 chr8:143751801 JRK 0.51 7.21 0.37 3.71e-12 Schizophrenia; LUSC cis rs12421382 0.507 rs11600810 chr11:109356443 G/A cg16359550 chr11:109292809 C11orf87 0.48 8.29 0.41 2.75e-15 Schizophrenia; LUSC cis rs4919687 0.550 rs10748828 chr10:104456794 C/T cg04362960 chr10:104952993 NT5C2 -0.48 -6.88 -0.35 2.9e-11 Colorectal cancer; LUSC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.51 0.34 2.77e-10 Menopause (age at onset); LUSC cis rs4746818 1.000 rs10998614 chr10:70923347 G/T cg11621586 chr10:70884670 VPS26A 1.08 13.38 0.59 5.7e-33 Left atrial antero-posterior diameter; LUSC cis rs62400317 0.859 rs10948223 chr6:45273921 A/C cg20913747 chr6:44695427 NA -0.45 -7.43 -0.38 9.39e-13 Total body bone mineral density; LUSC cis rs2730245 0.527 rs2527205 chr7:158706393 G/T cg11984989 chr7:158649758 WDR60 -1.08 -13.19 -0.59 2.83e-32 Height; LUSC cis rs3008870 0.755 rs2755271 chr1:67474977 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.75 12.26 0.56 8.64e-29 Lymphocyte percentage of white cells; LUSC cis rs11640436 0.690 rs35010194 chr16:77323769 C/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.37 5.83 0.3 1.31e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs7605827 0.930 rs7578787 chr2:15655119 T/C cg19274914 chr2:15703543 NA 0.46 8.83 0.43 6.22e-17 Educational attainment (years of education); LUSC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg23283495 chr1:209979779 IRF6 0.62 9.03 0.44 1.42e-17 Cleft lip with or without cleft palate; LUSC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg17264618 chr3:40429014 ENTPD3 0.34 7.25 0.37 2.94e-12 Renal cell carcinoma; LUSC cis rs12421382 0.616 rs2357795 chr11:109381135 C/T cg11473876 chr11:109292803 C11orf87 0.39 6.41 0.33 4.97e-10 Schizophrenia; LUSC cis rs2456568 0.548 rs10466335 chr11:93663820 G/C cg17595323 chr11:93583763 C11orf90 -0.32 -5.84 -0.3 1.26e-8 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs6495122 0.532 rs2472304 chr15:75044238 G/A cg10253484 chr15:75165896 SCAMP2 -0.42 -5.9 -0.31 8.89e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; LUSC cis rs7408868 1.000 rs4809030 chr19:15273381 A/G cg14696996 chr19:15285081 NOTCH3 1.02 9.37 0.46 1.1e-18 Pulse pressure; LUSC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg05368731 chr17:41323189 NBR1 0.92 15.73 0.65 4.08e-42 Menopause (age at onset); LUSC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg23711669 chr6:146136114 FBXO30 -0.9 -17.4 -0.69 9.72e-49 Lobe attachment (rater-scored or self-reported); LUSC cis rs2274273 0.870 rs2016931 chr14:55842332 C/G cg04306507 chr14:55594613 LGALS3 0.53 11.83 0.54 3.33e-27 Protein biomarker; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg26233468 chr1:155145786 TRIM46;KRTCAP2 0.44 6.22 0.32 1.5e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg11764359 chr7:65958608 NA 0.82 13.74 0.6 2.25e-34 Aortic root size; LUSC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -6.94 -0.36 1.99e-11 Alzheimer's disease (late onset); LUSC cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.56 -7.27 -0.37 2.52e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2456568 0.503 rs4254038 chr11:93666978 T/C cg26875233 chr11:93583750 C11orf90 -0.31 -5.95 -0.31 6.81e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg25036284 chr2:26402008 FAM59B -0.73 -10.8 -0.51 1.54e-23 Gut microbiome composition (summer); LUSC cis rs2303282 0.716 rs8043596 chr16:56419303 T/C cg00500540 chr16:56394104 NA -0.42 -7.09 -0.36 7.83e-12 Breast cancer; LUSC cis rs7210086 0.808 rs6501558 chr17:70639488 T/C cg04206342 chr17:70636940 NA -0.4 -6.51 -0.34 2.83e-10 Ulcerative colitis; LUSC cis rs6835098 1.000 rs6814857 chr4:174082805 T/A cg08422745 chr4:174089978 GALNT7 -0.82 -12.97 -0.58 1.98e-31 Dementia and core Alzheimer's disease neuropathologic changes; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04925841 chr12:24715491 SOX5 0.41 6.3 0.33 9.55e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs477692 0.967 rs519690 chr10:131424033 G/A cg26102564 chr10:131424627 MGMT 0.39 6.16 0.32 2.05e-9 Response to temozolomide; LUSC trans rs3960554 0.741 rs28446604 chr7:75662518 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 9.61 0.47 1.78e-19 Eotaxin levels; LUSC trans rs11098499 0.789 rs1980024 chr4:120253047 C/T cg25214090 chr10:38739885 LOC399744 0.43 6.48 0.33 3.35e-10 Corneal astigmatism; LUSC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg18876405 chr7:65276391 NA -0.57 -9.3 -0.45 1.95e-18 Aortic root size; LUSC trans rs61931739 0.500 rs7955933 chr12:34473608 A/G cg26384229 chr12:38710491 ALG10B 0.79 13.4 0.59 4.63e-33 Morning vs. evening chronotype; LUSC cis rs4499344 0.657 rs402862 chr19:33111102 C/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.82 11.42 0.53 1e-25 Mean platelet volume; LUSC cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg26384229 chr12:38710491 ALG10B 0.88 15.08 0.64 1.52e-39 Morning vs. evening chronotype; LUSC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg07362569 chr17:61921086 SMARCD2 0.37 7.66 0.39 2.05e-13 Prudent dietary pattern; LUSC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg18196295 chr10:418757 DIP2C -0.52 -9.09 -0.45 9.21e-18 Psychosis in Alzheimer's disease; LUSC cis rs243505 0.898 rs243539 chr7:148403917 T/C cg09806900 chr7:148480153 CUL1 -0.49 -7.01 -0.36 1.37e-11 Inflammatory bowel disease;Crohn's disease; LUSC trans rs5756813 0.688 rs34891095 chr22:38126582 C/T cg19894588 chr14:64061835 NA -0.51 -6.59 -0.34 1.73e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs6541297 1.000 rs1997947 chr1:230283764 A/G cg05784532 chr1:230284198 GALNT2 -0.5 -7.53 -0.38 4.69e-13 Coronary artery disease; LUSC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.66 0.34 1.15e-10 Intelligence (multi-trait analysis); LUSC trans rs4713118 0.587 rs9393899 chr6:28133528 G/C cg06606381 chr12:133084897 FBRSL1 -0.46 -6.2 -0.32 1.62e-9 Parkinson's disease; LUSC cis rs6906287 0.647 rs11153748 chr6:118773609 A/G cg21191810 chr6:118973309 C6orf204 0.34 6.21 0.32 1.54e-9 Electrocardiographic conduction measures; LUSC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg19748678 chr4:122722346 EXOSC9 0.49 7.54 0.38 4.58e-13 Type 2 diabetes; LUSC trans rs236907 0.859 rs61807979 chr1:171764281 G/A cg13482142 chr2:234261155 NA 0.49 6.17 0.32 1.95e-9 Mean platelet volume; LUSC cis rs2806561 1.000 rs1571466 chr1:23449183 T/C cg19743168 chr1:23544995 NA 0.42 9.05 0.44 1.2e-17 Height; LUSC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg19318889 chr4:1322082 MAEA 0.4 6.42 0.33 4.64e-10 Longevity; LUSC cis rs1799949 1.000 rs8176103 chr17:41267050 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.09 0.32 3.02e-9 Menopause (age at onset); LUSC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg18404041 chr3:52824283 ITIH1 -0.6 -11.82 -0.54 3.75e-27 Bipolar disorder; LUSC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg12412775 chr1:25698385 RHCE -0.3 -6.24 -0.32 1.3e-9 Erythrocyte sedimentation rate; LUSC cis rs6596100 0.538 rs56157864 chr5:132267859 A/T cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Breast cancer; LUSC trans rs41419946 1.000 rs1952179 chr1:165404575 A/G cg06650914 chr18:74208293 NA -0.58 -5.97 -0.31 5.97e-9 Gut microbiome composition (winter); LUSC cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.63 -8.78 -0.43 8.52e-17 Body mass index (adult); LUSC cis rs4555082 1.000 rs7146683 chr14:105759385 A/G cg13114125 chr14:105738426 BRF1 -0.86 -14.36 -0.62 9.79e-37 Mean platelet volume;Platelet distribution width; LUSC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.87 0.35 3.17e-11 Intelligence (multi-trait analysis); LUSC cis rs992157 0.735 rs2271541 chr2:219082119 G/T cg20019365 chr2:219134978 PNKD;AAMP 0.5 7.81 0.39 7.71e-14 Colorectal cancer; LUSC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg23711669 chr6:146136114 FBXO30 0.91 17.67 0.7 8.33e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg07507251 chr3:52567010 NT5DC2 0.36 6.91 0.35 2.4e-11 Bipolar disorder; LUSC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg12564285 chr5:131593104 PDLIM4 0.51 8.97 0.44 2.12e-17 Acylcarnitine levels; LUSC cis rs1160297 0.609 rs10164801 chr2:53096014 C/T cg07782112 chr2:53107842 NA 0.43 6.99 0.36 1.51e-11 Hemostatic factors and hematological phenotypes; LUSC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg21699342 chr2:239360505 ASB1 0.56 10.44 0.5 2.76e-22 Multiple system atrophy; LUSC trans rs8002861 0.870 rs2875541 chr13:44417441 G/T cg12856521 chr11:46389249 DGKZ 0.41 6.52 0.34 2.54e-10 Leprosy; LUSC cis rs17818399 0.749 rs13000560 chr2:46790997 G/T cg02822958 chr2:46747628 ATP6V1E2 0.42 6.12 0.32 2.68e-9 Height; LUSC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg05855489 chr10:104503620 C10orf26 0.58 9.23 0.45 3.18e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs5769707 0.632 rs135871 chr22:50008969 A/G cg20744362 chr22:50050164 C22orf34 0.38 6.98 0.36 1.61e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg24642439 chr20:33292090 TP53INP2 0.49 7.42 0.38 9.78e-13 Glomerular filtration rate (creatinine); LUSC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg03433033 chr1:76189801 ACADM 0.84 15.06 0.64 1.77e-39 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg14004847 chr7:1930337 MAD1L1 -0.56 -8.49 -0.42 6.7e-16 Schizophrenia; LUSC cis rs6951245 0.706 rs1133116 chr7:1195215 A/C cg08132940 chr7:1081526 C7orf50 -0.48 -6.0 -0.31 5.14e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs637571 0.510 rs4930320 chr11:65576788 C/G cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -6.03 -0.31 4.43e-9 Eosinophil percentage of white cells; LUSC cis rs611744 0.583 rs1448148 chr8:109333074 T/A cg21045802 chr8:109455806 TTC35 0.5 7.73 0.39 1.27e-13 Dupuytren's disease; LUSC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg11494091 chr17:61959527 GH2 0.7 15.03 0.64 2.34e-39 Prudent dietary pattern; LUSC cis rs9467773 0.620 rs2504565 chr6:26656890 G/A cg09904177 chr6:26538194 HMGN4 0.66 11.62 0.54 1.95e-26 Intelligence (multi-trait analysis); LUSC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg19920283 chr7:105172520 RINT1 0.58 6.22 0.32 1.48e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.85 0.39 5.87e-14 Hip circumference adjusted for BMI; LUSC cis rs4253772 0.938 rs10154348 chr22:46638159 C/A cg09491104 chr22:46646882 C22orf40 -0.59 -6.48 -0.33 3.23e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 7.18 0.37 4.67e-12 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9549260 0.709 rs12585870 chr13:41199487 A/C cg21288729 chr13:41239152 FOXO1 0.6 9.21 0.45 3.75e-18 Red blood cell count; LUSC cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg06108461 chr20:60628389 TAF4 -0.75 -12.36 -0.56 3.68e-29 Body mass index; LUSC cis rs9811920 0.695 rs793497 chr3:99505610 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -5.74 -0.3 2.14e-8 Axial length; LUSC cis rs11122272 0.735 rs722302 chr1:231480152 A/C cg06096015 chr1:231504339 EGLN1 0.57 10.02 0.48 7.85e-21 Hemoglobin concentration; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06826115 chr15:67835137 MAP2K5 -0.37 -6.04 -0.31 4.19e-9 Electrocardiographic conduction measures; LUSC cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.39 -5.92 -0.31 8.08e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19669959 chr18:8706720 NA -0.39 -6.13 -0.32 2.42e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1448094 0.817 rs10863112 chr12:86330844 C/T cg16660971 chr17:78860029 RPTOR 0.37 6.06 0.31 3.71e-9 Major depressive disorder; LUSC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.48 -0.33 3.34e-10 Lung cancer; LUSC cis rs11122272 0.668 rs2472261 chr1:231505701 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.62 -9.54 -0.46 3.03e-19 Hemoglobin concentration; LUSC cis rs7561273 0.586 rs13418279 chr2:24349218 G/T cg06627628 chr2:24431161 ITSN2 -0.51 -6.8 -0.35 4.71e-11 Quantitative traits; LUSC cis rs617219 0.889 rs10044259 chr5:78471854 T/C cg24856658 chr5:78533917 JMY -0.29 -5.7 -0.3 2.59e-8 Betaine levels in individuals undergoing cardiac evaluation; LUSC cis rs763014 0.966 rs15564 chr16:677854 G/T cg00908189 chr16:619842 PIGQ 0.66 10.5 0.5 1.83e-22 Height; LUSC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg03676636 chr4:99064102 C4orf37 0.33 7.2 0.37 4.07e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs4704187 0.617 rs4704185 chr5:74471690 G/A cg03227963 chr5:74354835 NA 0.29 6.22 0.32 1.46e-9 Response to amphetamines; LUSC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs9420 1.000 rs543725 chr11:57483039 A/T cg23127183 chr11:57508653 C11orf31 -0.53 -8.13 -0.41 8.55e-15 Schizophrenia; LUSC trans rs76248362 1.000 rs9510910 chr13:24437265 C/G cg26511321 chr7:27196790 HOXA7 0.51 6.29 0.33 1.02e-9 3-hydroxypropylmercapturic acid levels in smokers; LUSC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg03433033 chr1:76189801 ACADM 0.83 14.6 0.62 1.09e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs12579753 0.917 rs12372724 chr12:82193628 C/T cg21231944 chr12:82153410 PPFIA2 -0.37 -5.66 -0.3 3.33e-8 Resting heart rate; LUSC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.01 0.48 8.12e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg04521409 chr20:34287082 ROMO1;NFS1 -0.45 -6.75 -0.35 6.64e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.73 12.98 0.58 1.75e-31 Personality dimensions; LUSC cis rs11971779 0.680 rs4077889 chr7:139033914 A/G cg07862535 chr7:139043722 LUC7L2 0.54 6.75 0.35 6.59e-11 Diisocyanate-induced asthma; LUSC cis rs6121246 0.909 rs6119651 chr20:30259246 G/T cg18721089 chr20:30220636 NA -0.33 -5.78 -0.3 1.73e-8 Mean corpuscular hemoglobin; LUSC cis rs11098499 0.954 rs12510138 chr4:120423935 C/G cg09307838 chr4:120376055 NA 0.78 11.13 0.52 1.07e-24 Corneal astigmatism; LUSC cis rs9653442 0.545 rs2009094 chr2:100765077 G/A cg07810366 chr2:100720526 AFF3 -0.45 -7.68 -0.39 1.83e-13 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg10792982 chr14:105748885 BRF1 -0.51 -9.54 -0.46 3.19e-19 Mean platelet volume;Platelet distribution width; LUSC cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg26384229 chr12:38710491 ALG10B -0.65 -10.24 -0.49 1.42e-21 Morning vs. evening chronotype; LUSC trans rs12145833 0.538 rs61833885 chr1:243397188 C/A cg25284624 chr1:224180302 NA 0.7 6.61 0.34 1.48e-10 Obesity (early onset extreme); LUSC cis rs6938 0.618 rs12912839 chr15:75221245 C/T cg17294928 chr15:75287854 SCAMP5 0.43 6.21 0.32 1.57e-9 Breast cancer; LUSC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.82e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6599077 0.950 rs2371141 chr3:40098918 C/T cg13683864 chr3:40499215 RPL14 -0.59 -7.4 -0.38 1.11e-12 Sleep-related phenotypes; LUSC cis rs7949030 1.000 rs2956993 chr11:62406162 G/T cg11742103 chr11:62369870 EML3;MTA2 -0.48 -8.28 -0.41 3.04e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg20821713 chr7:1055600 C7orf50 -0.56 -7.39 -0.37 1.2e-12 Bronchopulmonary dysplasia; LUSC cis rs9611519 0.780 rs5751071 chr22:41656332 G/A cg03806693 chr22:41940476 POLR3H -0.58 -8.67 -0.43 1.86e-16 Neuroticism; LUSC cis rs61931739 0.517 rs10844738 chr12:34059503 T/A cg06521331 chr12:34319734 NA -0.5 -8.33 -0.41 2.1e-15 Morning vs. evening chronotype; LUSC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.72 -9.28 -0.45 2.26e-18 Gut microbiome composition (summer); LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg24060327 chr5:131705240 SLC22A5 -0.53 -8.62 -0.43 2.81e-16 Acylcarnitine levels; LUSC cis rs2404602 0.610 rs28823285 chr15:77050395 T/C cg23625390 chr15:77176239 SCAPER -0.65 -10.04 -0.48 6.53e-21 Blood metabolite levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08757611 chr17:76250500 NA -0.41 -6.22 -0.32 1.52e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs921968 0.643 rs600057 chr2:219456737 A/G cg02176678 chr2:219576539 TTLL4 0.64 11.77 0.54 5.36e-27 Mean corpuscular hemoglobin concentration; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg09281601 chr5:171434020 FBXW11 0.7 6.14 0.32 2.31e-9 Cognitive performance; LUSC cis rs897080 0.515 rs1085495 chr2:44608982 A/G cg00619915 chr2:44497795 NA -0.39 -5.75 -0.3 1.97e-8 Height; LUSC cis rs1451375 0.617 rs745043 chr7:50543955 T/G cg18232548 chr7:50535776 DDC -0.53 -7.3 -0.37 2.17e-12 Malaria; LUSC cis rs514406 0.698 rs11206043 chr1:53402552 C/T cg24675658 chr1:53192096 ZYG11B -0.71 -11.73 -0.54 7.4e-27 Monocyte count; LUSC trans rs1728785 1.000 rs4783653 chr16:68562815 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 7.57 0.38 3.58e-13 Ulcerative colitis; LUSC cis rs7267979 0.932 rs6138600 chr20:25521346 A/T cg03522245 chr20:25566470 NINL 0.37 5.96 0.31 6.4e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs992157 0.965 rs62182826 chr2:219148723 C/A cg00012203 chr2:219082015 ARPC2 0.8 14.08 0.61 1.14e-35 Colorectal cancer; LUSC cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg18681998 chr4:17616180 MED28 0.86 15.49 0.65 3.49e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg09365446 chr1:150670422 GOLPH3L 0.53 8.25 0.41 3.6e-15 Tonsillectomy; LUSC cis rs1371867 0.846 rs1788167 chr8:101319996 C/T cg06636551 chr8:101224915 SPAG1 -0.4 -7.48 -0.38 6.69e-13 Atrioventricular conduction; LUSC cis rs4423214 1.000 rs11606631 chr11:71164121 C/A cg05163923 chr11:71159392 DHCR7 0.74 10.94 0.51 5.36e-24 Vitamin D levels; LUSC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.42 5.81 0.3 1.45e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs12681287 0.605 rs6471296 chr8:87374654 A/G cg27223183 chr8:87520930 FAM82B 0.44 6.21 0.32 1.59e-9 Caudate activity during reward; LUSC cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg10518543 chr12:38710700 ALG10B 0.42 5.91 0.31 8.54e-9 Morning vs. evening chronotype; LUSC cis rs7572644 0.766 rs13008539 chr2:28174407 A/C cg27432699 chr2:27873401 GPN1 0.52 6.47 0.33 3.41e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6977660 1.000 rs13233821 chr7:19813637 A/C cg07541023 chr7:19748670 TWISTNB 0.55 6.34 0.33 7.47e-10 Thyroid stimulating hormone; LUSC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg24531977 chr5:56204891 C5orf35 -0.99 -14.89 -0.63 8.55e-39 Initial pursuit acceleration; LUSC cis rs4295623 0.585 rs34421088 chr8:11589042 A/G cg00262122 chr8:11665843 FDFT1 -0.42 -6.21 -0.32 1.56e-9 Morning vs. evening chronotype; LUSC trans rs1814175 0.935 rs10839317 chr11:49657228 A/C cg15704280 chr7:45808275 SEPT13 -1.09 -22.07 -0.77 3.31e-67 Height; LUSC cis rs4478858 0.698 rs6669381 chr1:31833506 A/G cg00250761 chr1:31883323 NA -0.36 -8.67 -0.43 1.97e-16 Alcohol dependence; LUSC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg09904177 chr6:26538194 HMGN4 0.45 6.47 0.33 3.51e-10 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg27266027 chr21:40555129 PSMG1 -0.4 -5.78 -0.3 1.76e-8 Cognitive function; LUSC cis rs228769 0.562 rs228762 chr17:42138392 C/T cg19774624 chr17:42201019 HDAC5 0.64 7.41 0.38 1.04e-12 Bone mineral density (hip);Bone mineral density (spine); LUSC cis rs3772130 0.962 rs9883467 chr3:121517833 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.69 10.21 0.49 1.78e-21 Cognitive performance; LUSC trans rs2392780 0.536 rs620808 chr8:128335714 C/T cg10897648 chr18:56338258 MALT1 -0.41 -6.21 -0.32 1.56e-9 Breast cancer (early onset); LUSC cis rs7589342 0.929 rs13024715 chr2:106433950 A/G cg16077055 chr2:106428750 NCK2 0.38 7.26 0.37 2.75e-12 Addiction; LUSC trans rs853679 0.607 rs13205211 chr6:28203056 T/G cg01620082 chr3:125678407 NA -0.86 -7.5 -0.38 5.97e-13 Depression; LUSC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg05717871 chr11:638507 DRD4 -0.35 -6.1 -0.32 3.01e-9 Systemic lupus erythematosus; LUSC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg24154853 chr7:158122151 PTPRN2 0.37 6.84 0.35 3.88e-11 Calcium levels; LUSC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg13175981 chr1:150552382 MCL1 0.54 7.67 0.39 1.85e-13 Tonsillectomy; LUSC cis rs7296418 0.961 rs1790094 chr12:123586688 T/C cg00376283 chr12:123451042 ABCB9 0.8 12.18 0.55 1.67e-28 Platelet count; LUSC cis rs506338 0.517 rs516117 chr11:64433444 T/C cg19395706 chr11:64412079 NRXN2 0.29 5.92 0.31 7.91e-9 Body mass index;Urate levels; LUSC cis rs2456568 0.548 rs6483281 chr11:93661840 G/C cg26875233 chr11:93583750 C11orf90 -0.31 -6.06 -0.31 3.76e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs13256369 0.708 rs11783670 chr8:8559394 G/A cg06671706 chr8:8559999 CLDN23 0.5 6.49 0.33 3.11e-10 Obesity-related traits; LUSC cis rs9650657 0.812 rs4240669 chr8:10629987 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -6.17 -0.32 2.02e-9 Neuroticism; LUSC cis rs6546537 0.550 rs6546531 chr2:69779963 C/A cg10773587 chr2:69614142 GFPT1 -0.42 -6.66 -0.34 1.14e-10 Serum thyroid-stimulating hormone levels; LUSC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg04518342 chr5:131593106 PDLIM4 0.45 7.89 0.4 4.38e-14 Breast cancer; LUSC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg19812747 chr11:111475976 SIK2 0.54 7.67 0.39 1.85e-13 Primary sclerosing cholangitis; LUSC trans rs12310956 0.515 rs11052934 chr12:33970381 T/C cg26384229 chr12:38710491 ALG10B 0.66 10.41 0.49 3.56e-22 Morning vs. evening chronotype; LUSC cis rs4843185 0.731 rs3815795 chr16:85712105 A/G cg05245094 chr16:85669572 KIAA0182 -0.42 -6.26 -0.32 1.21e-9 Platelet distribution width; LUSC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 6.03 0.31 4.3e-9 Intelligence (multi-trait analysis); LUSC cis rs9326248 0.539 rs518181 chr11:116772787 C/A cg11861562 chr11:117069780 TAGLN 0.35 6.72 0.35 7.69e-11 Blood protein levels; LUSC cis rs694739 0.657 rs11231770 chr11:64140625 G/A cg02228329 chr11:64053129 BAD;GPR137 0.44 6.26 0.32 1.17e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs4285028 0.731 rs2332035 chr3:121715432 C/T cg11130432 chr3:121712080 ILDR1 -0.66 -10.81 -0.51 1.44e-23 Multiple sclerosis; LUSC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg14893161 chr1:205819251 PM20D1 -0.45 -6.65 -0.34 1.17e-10 Parkinson's disease; LUSC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.89 15.85 0.66 1.36e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.47e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs3857536 0.674 rs9345798 chr6:66951331 A/G cg07460842 chr6:66804631 NA -0.46 -6.36 -0.33 6.75e-10 Blood trace element (Cu levels); LUSC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg09455208 chr3:40491958 NA 0.52 8.95 0.44 2.6e-17 Renal cell carcinoma; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg27353073 chr11:76092311 PRKRIR -0.46 -6.82 -0.35 4.25e-11 Electrocardiographic conduction measures; LUSC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg27286337 chr10:134555280 INPP5A 0.9 11.66 0.54 1.37e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2073300 1.000 rs6137971 chr20:23456429 G/T cg09953122 chr20:23471693 CST8 -0.87 -7.42 -0.38 9.64e-13 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg16989086 chr20:62203971 PRIC285 0.46 6.48 0.33 3.27e-10 Glioblastoma; LUSC cis rs11039100 0.850 rs11039121 chr11:5833161 T/C cg13902645 chr11:5959945 NA -0.54 -6.0 -0.31 5.2e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC trans rs60843830 0.661 rs11674325 chr2:105517 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.51 8.02 0.4 1.79e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.49 0.56 1.26e-29 Motion sickness; LUSC cis rs7246657 1.000 rs34544865 chr19:37801242 G/C cg23950597 chr19:37808831 NA -0.59 -6.5 -0.33 2.99e-10 Coronary artery calcification; LUSC trans rs61931739 0.929 rs10844748 chr12:34092930 G/T cg13010199 chr12:38710504 ALG10B -0.46 -7.33 -0.37 1.73e-12 Morning vs. evening chronotype; LUSC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.42 6.68 0.34 9.71e-11 Menopause (age at onset); LUSC cis rs807669 0.525 rs738904 chr22:19167385 C/A cg02655711 chr22:19163373 SLC25A1 0.52 9.49 0.46 4.61e-19 Metabolite levels; LUSC cis rs12101261 0.556 rs2300516 chr14:81446908 A/G cg06600135 chr14:81408086 NA 0.46 7.1 0.36 7.47e-12 Graves' disease; LUSC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg23711669 chr6:146136114 FBXO30 -0.78 -12.87 -0.58 4.79e-31 Lobe attachment (rater-scored or self-reported); LUSC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg01879757 chr17:41196368 BRCA1 -0.47 -7.16 -0.36 5.11e-12 Menopause (age at onset); LUSC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg21918786 chr6:109611834 NA -0.35 -5.84 -0.3 1.21e-8 Reticulocyte fraction of red cells; LUSC cis rs9467711 0.720 rs9348716 chr6:26375658 G/A cg09904177 chr6:26538194 HMGN4 -0.73 -6.89 -0.35 2.78e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg13939156 chr17:80058883 NA -0.34 -6.64 -0.34 1.27e-10 Life satisfaction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg00029053 chr2:10830014 NOL10 0.45 6.81 0.35 4.54e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs941873 0.868 rs7332 chr10:81114060 G/A cg11057378 chr10:81107060 PPIF 0.37 6.21 0.32 1.57e-9 Height; LUSC cis rs7833986 0.534 rs2976022 chr8:57007843 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.75 12.2 0.56 1.4e-28 Height; LUSC cis rs644799 0.562 rs654345 chr11:95581865 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.64 9.18 0.45 4.55e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs760805 1.000 rs61774728 chr1:25258867 G/C cg22509179 chr1:25234806 RUNX3 -0.6 -10.08 -0.48 4.72e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg11871910 chr12:69753446 YEATS4 0.82 13.96 0.61 3.16e-35 Blood protein levels; LUSC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg18305652 chr10:134549665 INPP5A 0.45 6.73 0.35 7.36e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs500891 0.533 rs35156665 chr6:84143765 C/T cg08257003 chr6:84140564 ME1 0.35 8.52 0.42 5.36e-16 Platelet-derived growth factor BB levels; LUSC cis rs11098499 0.663 rs9996501 chr4:120238918 C/A cg24375607 chr4:120327624 NA 0.76 11.87 0.54 2.32e-27 Corneal astigmatism; LUSC cis rs4561483 0.801 rs251723 chr16:11953080 G/C cg08843971 chr16:11963173 GSPT1 -0.49 -7.22 -0.37 3.56e-12 Testicular germ cell tumor; LUSC cis rs8077889 1.000 rs59044152 chr17:41888747 A/G cg26893861 chr17:41843967 DUSP3 0.98 14.71 0.63 4.09e-38 Triglycerides; LUSC cis rs709400 0.663 rs3783402 chr14:103967929 C/G cg12935359 chr14:103987150 CKB -0.51 -7.83 -0.39 6.43e-14 Body mass index; LUSC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg26769984 chr7:1090371 C7orf50 0.75 10.55 0.5 1.23e-22 Bronchopulmonary dysplasia; LUSC trans rs2228479 0.681 rs10153196 chr16:89967397 A/C cg24644049 chr4:85504048 CDS1 0.72 7.32 0.37 1.91e-12 Skin colour saturation; LUSC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg07959070 chr22:50026188 C22orf34 -0.34 -6.95 -0.36 1.98e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg13683864 chr3:40499215 RPL14 1.06 19.49 0.73 4.7e-57 Renal cell carcinoma; LUSC cis rs1982963 1.000 rs2749876 chr14:52504397 T/G cg10843707 chr14:52510701 NID2 -0.41 -6.62 -0.34 1.4e-10 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7804356 1.000 rs73067443 chr7:26851074 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 1.93e-9 Type 1 diabetes; LUSC trans rs853679 0.769 rs7752448 chr6:28301099 A/G cg06606381 chr12:133084897 FBRSL1 -0.69 -6.72 -0.35 8.01e-11 Depression; LUSC trans rs72674100 1.000 rs2865753 chr4:97992752 A/T cg16405019 chr1:18959625 PAX7 -0.61 -6.41 -0.33 5.09e-10 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg27446573 chr6:127587934 RNF146 0.7 10.91 0.51 6.34e-24 Breast cancer; LUSC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg04267008 chr7:1944627 MAD1L1 -0.6 -9.21 -0.45 3.82e-18 Bipolar disorder and schizophrenia; LUSC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg15790184 chr11:494944 RNH1 0.49 7.3 0.37 2.18e-12 Systemic lupus erythematosus; LUSC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg22496380 chr5:211416 CCDC127 -0.74 -8.61 -0.43 2.96e-16 Breast cancer; LUSC cis rs10751667 0.925 rs7115336 chr11:988101 C/G cg06064525 chr11:970664 AP2A2 -0.36 -7.07 -0.36 8.88e-12 Alzheimer's disease (late onset); LUSC cis rs10089 1.000 rs10060390 chr5:127452947 C/T cg19767477 chr5:127420684 SLC12A2 -0.43 -5.77 -0.3 1.86e-8 Ileal carcinoids; LUSC trans rs4650994 0.525 rs4651000 chr1:178532223 A/G cg05059571 chr16:84539110 KIAA1609 -0.47 -8.98 -0.44 1.96e-17 HDL cholesterol levels;HDL cholesterol; LUSC trans rs853679 0.607 rs13211507 chr6:28257377 T/C cg06606381 chr12:133084897 FBRSL1 -0.92 -8.91 -0.44 3.32e-17 Depression; LUSC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg06634786 chr22:41940651 POLR3H 0.52 6.13 0.32 2.43e-9 Vitiligo; LUSC cis rs4363385 0.720 rs6672735 chr1:152981086 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -5.7 -0.3 2.69e-8 Inflammatory skin disease; LUSC cis rs4285028 0.747 rs9838301 chr3:121375144 G/T cg11130432 chr3:121712080 ILDR1 -0.58 -8.46 -0.42 8.21e-16 Multiple sclerosis; LUSC cis rs6940638 0.688 rs1028308 chr6:27129757 G/A cg12292205 chr6:26970375 C6orf41 -0.39 -5.8 -0.3 1.55e-8 Intelligence (multi-trait analysis); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01156768 chr18:77439120 CTDP1 -0.43 -6.4 -0.33 5.26e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs60843830 0.661 rs7588043 chr2:104979 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.51 8.01 0.4 1.94e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg12011299 chr4:100065546 ADH4 0.61 9.71 0.47 8.65e-20 Alcohol dependence; LUSC cis rs4363385 0.791 rs512198 chr1:153006245 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -5.68 -0.3 2.9e-8 Inflammatory skin disease; LUSC trans rs3733585 0.699 rs57574512 chr4:9960182 T/C cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs629535 0.773 rs568159 chr8:70032908 C/G cg21567404 chr3:27674614 NA 0.96 15.09 0.64 1.41e-39 Dupuytren's disease; LUSC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg11644478 chr21:40555479 PSMG1 -0.65 -9.92 -0.48 1.63e-20 Menarche (age at onset); LUSC cis rs7789940 1.000 rs7789940 chr7:75951230 A/G cg15798862 chr7:76129360 DTX2 -0.51 -8.38 -0.42 1.5e-15 Multiple sclerosis; LUSC cis rs3931020 0.688 rs1051122 chr1:75190452 C/T cg21906852 chr1:75198582 TYW3;CRYZ 0.45 5.89 0.31 9.55e-9 Resistin levels; LUSC cis rs7586879 0.964 rs11688665 chr2:25121168 G/T cg15423357 chr2:25149977 NA 0.35 6.4 0.33 5.19e-10 Body mass index; LUSC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg24531977 chr5:56204891 C5orf35 -0.98 -14.66 -0.63 6.33e-38 Initial pursuit acceleration; LUSC cis rs826838 0.904 rs11612004 chr12:39204282 G/A cg13010199 chr12:38710504 ALG10B 0.69 11.78 0.54 5.17e-27 Heart rate; LUSC cis rs9814567 1.000 rs7619451 chr3:134233238 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -12.71 -0.57 1.79e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 7.09 0.36 7.93e-12 Bipolar disorder; LUSC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs9796 0.621 rs690733 chr15:41476465 G/A cg18705301 chr15:41695430 NDUFAF1 -0.5 -8.78 -0.43 8.74e-17 Menopause (age at onset); LUSC cis rs12908161 1.000 rs58416181 chr15:85264461 G/A cg17507749 chr15:85114479 UBE2QP1 0.57 7.12 0.36 6.66e-12 Schizophrenia; LUSC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -7.11 -0.36 7.22e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs10506458 1.000 rs73128794 chr12:63445313 C/T cg22491629 chr6:157744540 C6orf35 -0.9 -10.67 -0.5 4.68e-23 Hemostatic factors and hematological phenotypes; LUSC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg05890377 chr2:74357713 NA 0.56 8.63 0.43 2.55e-16 Gestational age at birth (maternal effect); LUSC cis rs262150 0.522 rs2527182 chr7:158813812 A/G cg09640425 chr7:158790006 NA -0.52 -8.19 -0.41 5.5e-15 Facial morphology (factor 20); LUSC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg05340658 chr4:99064831 C4orf37 0.65 11.2 0.52 6.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4595586 0.545 rs2197940 chr12:39401937 C/T cg26384229 chr12:38710491 ALG10B 0.49 7.06 0.36 9.57e-12 Morning vs. evening chronotype; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg07217954 chr7:1067459 C7orf50 0.54 5.71 0.3 2.5e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs61863818 0.533 rs954148 chr10:99123006 T/C cg08345082 chr10:99160200 RRP12 -0.29 -5.87 -0.31 1.04e-8 Monocyte percentage of white cells; LUSC cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg05347473 chr6:146136440 FBXO30 0.52 8.79 0.43 8.31e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg11645453 chr3:52864694 ITIH4 0.35 8.16 0.41 6.88e-15 Bipolar disorder; LUSC trans rs2324999 0.607 rs59778458 chr3:86182889 C/G cg20214535 chr21:43619310 ABCG1 -0.36 -6.19 -0.32 1.79e-9 Subcutaneous adipose tissue; LUSC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg18758796 chr5:131593413 PDLIM4 0.39 6.58 0.34 1.78e-10 Breast cancer; LUSC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs7572644 0.662 rs12465103 chr2:28199736 G/C cg27432699 chr2:27873401 GPN1 -0.51 -6.99 -0.36 1.52e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg16339924 chr4:17578868 LAP3 0.59 9.03 0.44 1.38e-17 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1372520 1.000 rs1372520 chr4:90757505 T/C cg01966878 chr4:90757139 SNCA -0.42 -5.93 -0.31 7.41e-9 Neuroticism; LUSC trans rs8072100 1.000 rs4794016 chr17:45725931 T/A cg03886242 chr7:26192032 NFE2L3 0.39 6.44 0.33 4.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.5 0.38 5.97e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs7937682 0.924 rs4630327 chr11:111539327 C/T cg22437258 chr11:111473054 SIK2 -0.5 -6.84 -0.35 3.88e-11 Primary sclerosing cholangitis; LUSC cis rs5758511 0.514 rs5758580 chr22:42493875 T/C cg00645731 chr22:42541494 CYP2D7P1 0.6 10.05 0.48 6.31e-21 Birth weight; LUSC trans rs3733585 0.664 rs17185870 chr4:9958214 C/A cg26043149 chr18:55253948 FECH -0.46 -7.05 -0.36 1.06e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs12478296 0.591 rs7573042 chr2:242996589 A/G cg06360820 chr2:242988706 NA -0.57 -7.34 -0.37 1.68e-12 Obesity-related traits; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24151027 chr5:77656318 SCAMP1 -0.42 -7.16 -0.36 5.21e-12 Electrocardiographic conduction measures; LUSC cis rs4343996 0.536 rs10228055 chr7:3414750 G/A cg21248987 chr7:3385318 SDK1 0.34 5.71 0.3 2.44e-8 Motion sickness; LUSC cis rs4356932 1.000 rs6828596 chr4:76961373 A/G cg00809888 chr4:76862425 NAAA 0.35 5.92 0.31 7.86e-9 Blood protein levels; LUSC cis rs7582720 1.000 rs115654617 chr2:203893999 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 8.79 0.43 7.92e-17 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg09658497 chr7:2847517 GNA12 -0.35 -5.91 -0.31 8.3e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); LUSC cis rs16866061 1.000 rs16866061 chr2:225439844 A/G cg12698349 chr2:225449008 CUL3 0.82 12.98 0.58 1.86e-31 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC trans rs1941687 0.764 rs1493915 chr18:31377582 G/T cg27147174 chr7:100797783 AP1S1 -0.51 -7.91 -0.4 3.89e-14 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.58 -0.34 1.84e-10 Arsenic metabolism; LUSC trans rs6502050 0.871 rs8066137 chr17:80074316 T/C cg07393940 chr7:158741817 NA -0.37 -6.56 -0.34 1.99e-10 Life satisfaction; LUSC cis rs4363385 0.510 rs11590369 chr1:152903603 G/C cg00922841 chr1:152955080 SPRR1A -0.39 -6.34 -0.33 7.28e-10 Inflammatory skin disease; LUSC cis rs929354 0.742 rs7806775 chr7:156947199 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.45 -0.46 6.32e-19 Body mass index; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg04720665 chr1:245028075 HNRNPU -0.45 -6.11 -0.32 2.72e-9 Hepatitis; LUSC cis rs7582180 0.700 rs11685293 chr2:100976502 A/C cg08017756 chr2:100939284 LONRF2 -0.44 -8.28 -0.41 2.98e-15 Intelligence (multi-trait analysis); LUSC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg18099408 chr3:52552593 STAB1 -0.39 -6.9 -0.35 2.66e-11 Bipolar disorder; LUSC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 6.98 0.36 1.62e-11 Bipolar disorder; LUSC cis rs10740039 0.842 rs7080024 chr10:62391791 A/G cg18175470 chr10:62150864 ANK3 0.48 7.43 0.38 9.38e-13 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.89 0.48 2.19e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs2932538 0.922 rs12406906 chr1:113117900 G/T cg22162597 chr1:113214053 CAPZA1 -0.69 -10.07 -0.48 5.3e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs1784581 0.588 rs9295180 chr6:162420579 T/C cg17173639 chr6:162384350 PARK2 0.57 9.98 0.48 1.06e-20 Itch intensity from mosquito bite; LUSC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg21248554 chr2:27665150 KRTCAP3 -0.29 -5.81 -0.3 1.48e-8 Total body bone mineral density; LUSC cis rs6964587 1.000 rs12666179 chr7:91574110 T/C cg17063962 chr7:91808500 NA -0.56 -9.0 -0.44 1.74e-17 Breast cancer; LUSC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg22105103 chr4:187893119 NA 0.72 14.09 0.61 1e-35 Lobe attachment (rater-scored or self-reported); LUSC cis rs2404602 0.684 rs12591622 chr15:76930655 A/T cg23625390 chr15:77176239 SCAPER -0.66 -9.93 -0.48 1.55e-20 Blood metabolite levels; LUSC cis rs12579753 0.871 rs10862362 chr12:82199383 T/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.15 -0.32 2.27e-9 Resting heart rate; LUSC cis rs12760731 0.720 rs12047646 chr1:178274083 G/A cg00404053 chr1:178313656 RASAL2 0.64 6.76 0.35 6.32e-11 Obesity-related traits; LUSC cis rs9463078 0.683 rs227851 chr6:44699209 A/C cg25276700 chr6:44698697 NA 0.3 5.85 0.31 1.15e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs11630290 0.639 rs925248 chr15:64167543 G/A cg12036633 chr15:63758958 NA 0.5 6.1 0.32 2.89e-9 Iris characteristics; LUSC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg16228356 chr17:43848958 NA -0.27 -6.27 -0.32 1.1e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs34779708 0.931 rs7099036 chr10:35349574 C/T cg04310649 chr10:35416472 CREM -0.42 -6.47 -0.33 3.5e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1908814 0.516 rs11250178 chr8:11800234 A/C cg21775007 chr8:11205619 TDH 0.45 6.4 0.33 5.13e-10 Neuroticism; LUSC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.2e-17 Tonsillectomy; LUSC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg05717871 chr11:638507 DRD4 -0.36 -5.89 -0.31 9.43e-9 Systemic lupus erythematosus; LUSC cis rs952623 0.649 rs12538487 chr7:39075380 A/G cg15212455 chr7:39170539 POU6F2 0.36 5.96 0.31 6.42e-9 Intelligence (multi-trait analysis); LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg08283293 chr5:175964814 RNF44 0.46 6.15 0.32 2.24e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs4619890 0.672 rs6446621 chr4:7810507 A/T cg00251875 chr4:7801337 AFAP1 -0.41 -5.72 -0.3 2.31e-8 Glaucoma (primary open-angle); LUSC trans rs9393777 0.720 rs56401801 chr6:27301512 T/A cg01620082 chr3:125678407 NA -0.75 -6.6 -0.34 1.66e-10 Intelligence (multi-trait analysis); LUSC cis rs601339 1.000 rs7969523 chr12:123168636 T/G cg11919336 chr12:123188078 GPR109A 0.42 6.23 0.32 1.37e-9 Adiponectin levels; LUSC cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -8.72 -0.43 1.34e-16 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2274273 0.967 rs8009670 chr14:55583477 G/A cg04306507 chr14:55594613 LGALS3 0.56 12.84 0.57 6.2e-31 Protein biomarker; LUSC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg12927641 chr6:109611667 NA -0.34 -5.77 -0.3 1.81e-8 Reticulocyte fraction of red cells; LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs6834538 0.597 rs2029211 chr4:113488134 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.34 5.72 0.3 2.31e-8 Free thyroxine concentration; LUSC cis rs2204008 0.539 rs1283295 chr12:38146014 A/C cg26384229 chr12:38710491 ALG10B -0.67 -10.36 -0.49 5.26e-22 Bladder cancer; LUSC cis rs354225 0.544 rs7556752 chr2:54810044 G/C cg01766943 chr2:54829624 SPTBN1 0.49 7.9 0.4 4.21e-14 Schizophrenia; LUSC trans rs7615952 0.611 rs2947646 chr3:125593602 C/T cg07211511 chr3:129823064 LOC729375 1.02 12.41 0.56 2.46e-29 Blood pressure (smoking interaction); LUSC cis rs12701220 0.817 rs59471534 chr7:1085224 G/A cg00990874 chr7:1149470 C7orf50 -0.48 -6.37 -0.33 6.26e-10 Bronchopulmonary dysplasia; LUSC cis rs7683537 0.887 rs4540092 chr4:185633546 A/G cg04058563 chr4:185651563 MLF1IP 0.87 13.33 0.59 8.18e-33 Systemic lupus erythematosus; LUSC trans rs11992162 0.551 rs35010200 chr8:11785655 G/A cg14343924 chr8:8086146 FLJ10661 -0.44 -5.98 -0.31 5.87e-9 Monocyte count; LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg26314531 chr2:26401878 FAM59B 0.72 10.07 0.48 5.09e-21 Gut microbiome composition (summer); LUSC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg20243544 chr17:37824526 PNMT 0.57 7.44 0.38 8.51e-13 Glomerular filtration rate (creatinine); LUSC cis rs57590327 0.527 rs11917558 chr3:81610805 G/A cg07356753 chr3:81810745 GBE1 -0.42 -5.65 -0.3 3.41e-8 Extraversion; LUSC cis rs1355223 0.583 rs2915178 chr11:34878051 C/T cg24088639 chr11:34937564 PDHX;APIP -0.5 -7.46 -0.38 7.55e-13 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs6142102 0.580 rs4911139 chr20:32551535 G/A cg24642439 chr20:33292090 TP53INP2 0.39 5.65 0.3 3.51e-8 Skin pigmentation; LUSC cis rs4951018 0.853 rs1573104 chr1:205636907 A/C cg17178900 chr1:205818956 PM20D1 -0.41 -5.77 -0.3 1.81e-8 Prostate-specific antigen levels; LUSC cis rs12602901 0.519 rs238238 chr17:4856376 A/G cg09495303 chr17:4804838 CHRNE;C17orf107 0.38 6.69 0.34 9.4e-11 Blood metabolite levels; LUSC cis rs548181 0.736 rs497344 chr11:125470524 T/C cg03464685 chr11:125439445 EI24 1.15 14.15 0.61 6.29e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg07362569 chr17:61921086 SMARCD2 -0.39 -7.82 -0.39 6.99e-14 Prudent dietary pattern; LUSC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg02018176 chr4:1364513 KIAA1530 0.5 8.54 0.42 4.76e-16 Obesity-related traits; LUSC cis rs6066835 1.000 rs6066815 chr20:47299870 T/C cg18078177 chr20:47281410 PREX1 0.76 5.96 0.31 6.36e-9 Multiple myeloma; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg05778415 chr2:75185968 POLE4 -0.44 -5.97 -0.31 5.99e-9 Bipolar disorder and schizophrenia; LUSC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg14092988 chr3:52407081 DNAH1 0.32 6.24 0.32 1.3e-9 Bipolar disorder; LUSC cis rs10193935 0.901 rs10179237 chr2:42515501 C/T cg27598129 chr2:42591480 NA -0.58 -8.0 -0.4 2e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs12477438 0.666 rs10179910 chr2:99658503 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -7.73 -0.39 1.29e-13 Chronic sinus infection; LUSC cis rs4713675 0.584 rs4713666 chr6:33679061 A/G cg14003231 chr6:33640908 ITPR3 0.29 5.69 0.3 2.82e-8 Plateletcrit; LUSC cis rs10089 1.000 rs3792866 chr5:127479900 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.86 11.94 0.55 1.31e-27 Ileal carcinoids; LUSC cis rs909002 0.849 rs2271933 chr1:32092525 C/T cg01639898 chr1:32083012 HCRTR1 -0.27 -6.4 -0.33 5.39e-10 Intelligence (multi-trait analysis); LUSC cis rs3820068 0.705 rs1800616 chr1:15832229 G/A cg17385448 chr1:15911702 AGMAT 0.38 6.08 0.32 3.19e-9 Systolic blood pressure; LUSC cis rs12464559 0.522 rs4414677 chr2:152624932 A/C cg01189475 chr2:152685088 ARL5A -0.63 -6.79 -0.35 5.09e-11 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs4906332 0.933 rs35999760 chr14:103924481 A/C cg04998671 chr14:104000505 TRMT61A -0.45 -7.06 -0.36 9.78e-12 Coronary artery disease; LUSC cis rs2976388 1.000 rs2294008 chr8:143761931 C/T cg17252645 chr8:143867129 LY6D -0.36 -6.2 -0.32 1.67e-9 Urinary tract infection frequency; LUSC cis rs2230307 0.518 rs2810425 chr1:100665072 G/C cg24955406 chr1:100503596 HIAT1 -0.57 -6.26 -0.32 1.15e-9 Carotid intima media thickness; LUSC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg12564285 chr5:131593104 PDLIM4 -0.44 -7.54 -0.38 4.45e-13 Breast cancer; LUSC cis rs11048434 0.761 rs1805721 chr12:9147569 A/G cg13575925 chr12:9217583 LOC144571 -0.34 -6.21 -0.32 1.58e-9 Sjögren's syndrome; LUSC cis rs804280 0.560 rs10503426 chr8:11589383 A/C cg00262122 chr8:11665843 FDFT1 0.44 6.49 0.33 3.13e-10 Myopia (pathological); LUSC cis rs13256369 0.802 rs13256404 chr8:8562974 T/C cg06671706 chr8:8559999 CLDN23 0.49 6.52 0.34 2.66e-10 Obesity-related traits; LUSC cis rs6545883 0.931 rs12713437 chr2:61722904 C/T cg15711740 chr2:61764176 XPO1 -0.5 -7.85 -0.39 5.89e-14 Tuberculosis; LUSC cis rs950169 0.887 rs3860265 chr15:84945185 C/T cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs6456156 0.586 rs4710176 chr6:167491639 T/C cg25258033 chr6:167368657 RNASET2 0.39 5.79 0.3 1.66e-8 Primary biliary cholangitis; LUSC trans rs2587949 0.615 rs2600134 chr3:4239099 C/T cg15139668 chr4:4577005 NA -0.41 -6.25 -0.32 1.25e-9 Periodontitis (DPAL); LUSC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -6.36 -0.33 6.46e-10 Total body bone mineral density; LUSC cis rs3862435 0.518 rs2444061 chr15:90909439 T/G cg22089800 chr15:90895588 ZNF774 0.59 6.5 0.33 2.97e-10 Response to exercise (triglyceride level interaction); LUSC cis rs4919694 1.000 rs12254254 chr10:104765605 C/T cg23093090 chr10:104574429 C10orf26 -0.47 -5.81 -0.3 1.49e-8 Arsenic metabolism; LUSC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.51 0.34 2.73e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6430585 0.640 rs6716070 chr2:136544651 G/T cg07169764 chr2:136633963 MCM6 -1.12 -16.85 -0.68 1.53e-46 Corneal structure; LUSC cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg12219531 chr12:120966889 COQ5 0.61 8.09 0.4 1.1e-14 High light scatter reticulocyte count; LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.09 -17.07 -0.68 2.02e-47 Gut microbiome composition (summer); LUSC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg21862992 chr11:68658383 NA 0.51 7.94 0.4 3.03e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg04414720 chr1:150670196 GOLPH3L 0.55 9.05 0.44 1.23e-17 Tonsillectomy; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg06938235 chr12:56498303 PA2G4 -0.55 -7.24 -0.37 3.03e-12 Bipolar disorder and schizophrenia; LUSC cis rs10216189 0.785 rs4352753 chr7:5527223 A/C cg11800390 chr7:5515995 FBXL18 0.31 6.52 0.34 2.64e-10 Relative hand skill in reading disability; LUSC trans rs853679 0.546 rs17695758 chr6:27837183 T/C cg09904177 chr6:26538194 HMGN4 -0.8 -6.0 -0.31 5.13e-9 Depression; LUSC cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg03213289 chr20:61660250 NA 0.68 14.09 0.61 1.04e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs12618769 0.571 rs72821939 chr2:99138872 T/C cg10123293 chr2:99228465 UNC50 0.46 7.67 0.39 1.95e-13 Bipolar disorder; LUSC cis rs9329221 0.935 rs3750311 chr8:10283602 C/A cg21775007 chr8:11205619 TDH -0.5 -7.14 -0.36 5.7e-12 Neuroticism; LUSC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg11859384 chr17:80120422 CCDC57 0.36 5.7 0.3 2.68e-8 Life satisfaction; LUSC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg06634786 chr22:41940651 POLR3H 0.53 6.15 0.32 2.16e-9 Vitiligo; LUSC cis rs1348850 0.537 rs3770010 chr2:178537796 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.43 5.85 0.3 1.19e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2742234 0.541 rs10793422 chr10:43703874 G/A cg15436174 chr10:43711423 RASGEF1A 0.44 7.0 0.36 1.43e-11 Hirschsprung disease; LUSC cis rs2731664 0.756 rs335433 chr5:176867207 T/C cg23176889 chr5:176863531 GRK6 -0.69 -14.34 -0.62 1.11e-36 Intelligence (multi-trait analysis); LUSC cis rs929354 0.772 rs2366214 chr7:156992461 A/G cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs977987 0.806 rs12051136 chr16:75435731 G/T cg03315344 chr16:75512273 CHST6 0.48 8.92 0.44 3.21e-17 Dupuytren's disease; LUSC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg09035930 chr12:129282057 SLC15A4 0.65 12.82 0.57 6.88e-31 Systemic lupus erythematosus; LUSC cis rs921968 0.565 rs7580147 chr2:219643036 A/G cg02176678 chr2:219576539 TTLL4 -0.56 -10.03 -0.48 7.4e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs7072216 0.881 rs6584192 chr10:100152373 T/G cg26618903 chr10:100175079 PYROXD2 -0.29 -5.64 -0.3 3.57e-8 Metabolite levels; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg01442334 chr4:110481823 CCDC109B -0.36 -6.25 -0.32 1.23e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11890956 chr21:40555474 PSMG1 -0.76 -11.74 -0.54 7.26e-27 Menarche (age at onset); LUSC cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg23788917 chr6:8435910 SLC35B3 0.5 7.49 0.38 6.2e-13 Motion sickness; LUSC trans rs6924906 0.529 rs1341224 chr6:82260446 T/C cg15052890 chr17:4636830 MED11;CXCL16 0.58 6.12 0.32 2.57e-9 Blood pressure; LUSC trans rs9291683 0.517 rs11736479 chr4:10017387 G/C cg26043149 chr18:55253948 FECH 0.49 7.31 0.37 2.03e-12 Bone mineral density; LUSC cis rs1018836 0.632 rs7017295 chr8:91482356 C/T cg16814680 chr8:91681699 NA 0.66 9.98 0.48 1.03e-20 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg19717773 chr7:2847554 GNA12 -0.39 -6.01 -0.31 4.81e-9 Height; LUSC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg26314531 chr2:26401878 FAM59B -0.72 -10.07 -0.48 5.09e-21 Gut microbiome composition (summer); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg00622682 chr22:32870857 FBXO7 -0.44 -6.55 -0.34 2.18e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9547692 1.000 rs61950374 chr13:37475485 C/T cg01493522 chr13:37497338 NA -0.45 -6.44 -0.33 4.13e-10 Coronary artery disease; LUSC cis rs12908161 0.959 rs12908699 chr15:85240403 G/T cg17173187 chr15:85201210 NMB 0.51 9.66 0.47 1.24e-19 Schizophrenia; LUSC cis rs4499344 0.633 rs411328 chr19:33140178 T/G cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.75 11.52 0.53 4.4e-26 Mean platelet volume; LUSC cis rs10782582 0.593 rs77208152 chr1:76124255 T/C cg10523679 chr1:76189770 ACADM -0.49 -7.16 -0.36 5.33e-12 Daytime sleep phenotypes; LUSC cis rs2230307 0.572 rs514090 chr1:100563186 C/G cg24955406 chr1:100503596 HIAT1 0.59 6.36 0.33 6.62e-10 Carotid intima media thickness; LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -10.51 -0.5 1.67e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs4911259 0.513 rs6057665 chr20:31463460 A/G cg09781936 chr22:19749961 TBX1 -0.33 -5.95 -0.31 6.85e-9 Inflammatory bowel disease; LUSC cis rs7809950 0.678 rs75617662 chr7:107030439 G/A cg23024343 chr7:107201750 COG5 -0.68 -9.97 -0.48 1.12e-20 Coronary artery disease; LUSC cis rs9393777 0.720 rs56874662 chr6:26985607 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.47 -5.82 -0.3 1.35e-8 Intelligence (multi-trait analysis); LUSC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg11584989 chr19:19387371 SF4 0.57 6.92 0.35 2.31e-11 Bipolar disorder; LUSC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg04315214 chr1:2043799 PRKCZ -0.38 -7.71 -0.39 1.44e-13 Height; LUSC cis rs7954584 0.567 rs11612028 chr12:122387872 C/G cg01765077 chr12:122356316 WDR66 0.54 7.82 0.39 7.14e-14 Mean corpuscular volume; LUSC cis rs3736594 0.765 rs12994085 chr2:27952406 C/T cg27432699 chr2:27873401 GPN1 -0.64 -8.99 -0.44 1.88e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs459571 0.959 rs416390 chr9:136908549 C/G cg01294253 chr9:136912663 BRD3 -0.35 -5.92 -0.31 8.09e-9 Platelet distribution width; LUSC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.6 -7.86 -0.4 5.29e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs35110281 0.693 rs2838345 chr21:45092715 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.61 10.36 0.49 5.35e-22 Mean corpuscular volume; LUSC trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -6.84 -0.35 3.75e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg19077165 chr18:44547161 KATNAL2 -0.39 -5.92 -0.31 8.17e-9 Personality dimensions; LUSC cis rs6960043 0.818 rs12699673 chr7:15049604 T/C cg19272540 chr7:15055459 NA 0.35 8.6 0.43 3.07e-16 Type 2 diabetes; LUSC cis rs11148252 0.595 rs9526974 chr13:53251040 C/G cg02158880 chr13:53174818 NA 0.54 9.28 0.45 2.22e-18 Lewy body disease; LUSC cis rs1878931 0.624 rs39728 chr16:3453076 A/T cg22508957 chr16:3507546 NAT15 -0.39 -5.81 -0.3 1.46e-8 Body mass index (adult); LUSC trans rs17685 0.735 rs11763339 chr7:75761541 T/C cg19862616 chr7:65841803 NCRNA00174 1.13 19.52 0.73 3.72e-57 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg12564285 chr5:131593104 PDLIM4 -0.37 -6.71 -0.34 8.43e-11 Breast cancer; LUSC cis rs57590327 0.555 rs3943556 chr3:81738892 G/C cg07356753 chr3:81810745 GBE1 -0.67 -10.37 -0.49 5.03e-22 Extraversion; LUSC cis rs6840360 1.000 rs3749561 chr4:152610117 C/T cg22705602 chr4:152727874 NA 0.3 6.31 0.33 8.88e-10 Intelligence (multi-trait analysis); LUSC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg09509183 chr1:209979624 IRF6 0.45 6.05 0.31 3.92e-9 Cleft lip with or without cleft palate; LUSC cis rs977987 0.645 rs10871311 chr16:75450912 T/A cg04384234 chr16:75411784 CFDP1 -0.42 -6.69 -0.34 9.63e-11 Dupuytren's disease; LUSC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg22800045 chr5:56110881 MAP3K1 0.77 9.51 0.46 3.83e-19 Initial pursuit acceleration; LUSC cis rs16912285 0.748 rs58504811 chr11:24252020 T/G ch.11.24196551F chr11:24239977 NA 0.88 8.96 0.44 2.29e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7520050 0.807 rs3013594 chr1:46138000 T/C cg24296786 chr1:45957014 TESK2 -0.4 -5.73 -0.3 2.26e-8 Red blood cell count;Reticulocyte count; LUSC trans rs11039798 0.588 rs10160381 chr11:48599491 A/G cg15704280 chr7:45808275 SEPT13 0.64 7.26 0.37 2.71e-12 Axial length; LUSC cis rs73206853 0.698 rs59574270 chr12:111112098 A/C cg12870014 chr12:110450643 ANKRD13A 0.69 7.38 0.37 1.3e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg09323728 chr8:95962352 TP53INP1 -0.45 -9.45 -0.46 6.1e-19 Type 2 diabetes; LUSC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg08109568 chr15:31115862 NA 0.73 10.96 0.51 4.45e-24 Huntington's disease progression; LUSC trans rs1814175 0.650 rs6486000 chr11:49659090 T/A cg15704280 chr7:45808275 SEPT13 -1.01 -18.0 -0.7 4.04e-51 Height; LUSC cis rs16854884 0.657 rs6791078 chr3:143736876 A/G cg06585982 chr3:143692056 C3orf58 0.5 7.93 0.4 3.36e-14 Economic and political preferences (feminism/equality); LUSC cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg21535247 chr6:8435926 SLC35B3 0.59 9.04 0.44 1.31e-17 Motion sickness; LUSC cis rs11711311 0.911 rs13321446 chr3:113522544 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -5.87 -0.31 1.03e-8 IgG glycosylation; LUSC cis rs67072384 0.818 rs6592483 chr11:72463974 A/G cg04827223 chr11:72435913 ARAP1 -0.82 -6.66 -0.34 1.15e-10 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs9473147 0.516 rs9395279 chr6:47542864 C/T cg20196966 chr6:47445060 CD2AP 0.42 5.87 0.31 1.07e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs12541635 0.677 rs4734892 chr8:106990088 G/C cg10147462 chr8:107024639 NA 0.65 13.51 0.59 1.73e-33 Age of smoking initiation; LUSC cis rs11785400 0.793 rs4567014 chr8:143737690 G/C cg24634471 chr8:143751801 JRK 0.51 7.29 0.37 2.28e-12 Schizophrenia; LUSC trans rs11039798 0.764 rs12418936 chr11:48986418 T/C cg15704280 chr7:45808275 SEPT13 0.8 6.9 0.35 2.64e-11 Axial length; LUSC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg12288994 chr5:1860383 NA 0.3 6.64 0.34 1.28e-10 Cardiovascular disease risk factors; LUSC cis rs6500602 0.893 rs6500601 chr16:4497199 G/C cg08645402 chr16:4508243 NA 0.49 7.64 0.39 2.37e-13 Schizophrenia; LUSC cis rs977987 0.778 rs8057849 chr16:75443816 T/C cg04384234 chr16:75411784 CFDP1 -0.41 -6.61 -0.34 1.52e-10 Dupuytren's disease; LUSC cis rs11158026 0.574 rs8019390 chr14:55409084 C/G cg04306507 chr14:55594613 LGALS3 0.36 6.47 0.33 3.44e-10 Parkinson's disease; LUSC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs11864453 0.611 rs9926927 chr16:72130556 G/T cg01557791 chr16:72042693 DHODH -0.43 -6.53 -0.34 2.42e-10 Fibrinogen levels; LUSC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.24 -0.32 1.32e-9 Total body bone mineral density; LUSC trans rs979233 0.502 rs276250 chr5:42062640 G/C cg07010552 chr17:7358735 CHRNB1 -0.41 -6.02 -0.31 4.72e-9 Systemic lupus erythematosus; LUSC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg22529645 chr1:3704559 LRRC47 0.37 6.43 0.33 4.48e-10 Red cell distribution width; LUSC cis rs12476592 0.714 rs262494 chr2:63845484 C/T cg10828910 chr2:63850056 LOC388955 0.51 6.31 0.33 8.77e-10 Childhood ear infection; LUSC cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg21535247 chr6:8435926 SLC35B3 0.58 8.94 0.44 2.76e-17 Motion sickness; LUSC cis rs12210905 0.688 rs12215289 chr6:27468705 T/C cg08851530 chr6:28072375 NA 0.95 6.15 0.32 2.21e-9 Hip circumference adjusted for BMI; LUSC cis rs17539620 0.519 rs4077066 chr6:154838448 C/G cg20019720 chr6:154832845 CNKSR3 0.61 9.42 0.46 7.81e-19 Lipoprotein (a) levels; LUSC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg25767906 chr1:53392781 SCP2 -0.62 -12.18 -0.55 1.78e-28 Monocyte count; LUSC cis rs68170813 0.599 rs12533516 chr7:106937135 C/T cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 4.02e-20 Coronary artery disease; LUSC cis rs1865721 0.728 rs8087297 chr18:73136221 T/A cg26385618 chr18:73139727 C18orf62 -0.54 -9.86 -0.47 2.71e-20 Intelligence; LUSC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg23172400 chr8:95962367 TP53INP1 -0.3 -5.75 -0.3 2.04e-8 Type 2 diabetes; LUSC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg13395646 chr4:1353034 KIAA1530 -0.64 -10.14 -0.49 3.1e-21 Obesity-related traits; LUSC cis rs3771570 0.901 rs73008106 chr2:242422446 C/T cg21155796 chr2:242212141 HDLBP 0.61 6.96 0.36 1.76e-11 Prostate cancer; LUSC cis rs34779708 0.966 rs34296409 chr10:35404613 C/G cg04310649 chr10:35416472 CREM -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11098499 0.615 rs59867181 chr4:120556467 C/T cg24375607 chr4:120327624 NA -0.63 -10.05 -0.48 6.3e-21 Corneal astigmatism; LUSC cis rs10992471 0.603 rs4744137 chr9:95288352 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.9 -0.35 2.68e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4948275 0.550 rs7904815 chr10:63136612 G/A cg03237606 chr10:63212265 TMEM26 -0.38 -5.84 -0.3 1.26e-8 Night sleep phenotypes; LUSC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg20406979 chr6:167373233 NA -0.26 -5.98 -0.31 5.75e-9 Crohn's disease; LUSC cis rs8177253 0.696 rs4459901 chr3:133465699 T/C cg08048268 chr3:133502702 NA -0.41 -7.49 -0.38 6.2e-13 Iron status biomarkers; LUSC cis rs7927771 0.524 rs10838758 chr11:47771476 T/C cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC cis rs2074585 0.647 rs2601188 chr15:90929563 A/G cg10434728 chr15:90938212 IQGAP1 -0.34 -7.42 -0.38 9.9e-13 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs12579753 0.871 rs1922540 chr12:82197496 A/G cg07988820 chr12:82153109 PPFIA2 -0.43 -6.12 -0.32 2.69e-9 Resting heart rate; LUSC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg03806693 chr22:41940476 POLR3H 0.97 13.39 0.59 4.91e-33 Crohn's disease;Inflammatory bowel disease; LUSC cis rs796364 0.806 rs11679676 chr2:201040981 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -7.35 -0.37 1.51e-12 Schizophrenia; LUSC cis rs2637266 1.000 rs2395388 chr10:78357203 C/T cg18941641 chr10:78392320 NA 0.39 7.13 0.36 6.4e-12 Pulmonary function; LUSC cis rs117623576 0.941 rs7912584 chr10:32416623 C/T cg03047570 chr10:32398778 NA -0.62 -6.63 -0.34 1.36e-10 Anti-saccade response; LUSC cis rs7582720 0.725 rs72934725 chr2:203725983 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.74 8.17 0.41 6.65e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg03806693 chr22:41940476 POLR3H -0.95 -13.44 -0.59 3.25e-33 Crohn's disease;Inflammatory bowel disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg25894440 chr7:65020034 NA 0.47 7.05 0.36 1.06e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12291225 0.585 rs10832246 chr11:14380828 G/A cg05501817 chr11:14380813 RRAS2 -0.55 -9.07 -0.44 1.04e-17 Sense of smell; LUSC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg25019033 chr10:957182 NA -0.46 -5.77 -0.3 1.79e-8 Eosinophil percentage of granulocytes; LUSC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg03452623 chr4:187889614 NA 0.87 17.96 0.7 6.2e-51 Lobe attachment (rater-scored or self-reported); LUSC cis rs7246657 0.551 rs12978093 chr19:37584416 C/T cg23950597 chr19:37808831 NA -0.55 -6.05 -0.31 3.86e-9 Coronary artery calcification; LUSC cis rs2635047 0.783 rs9952447 chr18:44784700 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 5.82 0.3 1.41e-8 Educational attainment; LUSC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg02551604 chr5:131831745 NA 0.44 6.89 0.35 2.75e-11 Asthma (sex interaction); LUSC cis rs9549260 0.755 rs7989711 chr13:41215696 C/T cg21288729 chr13:41239152 FOXO1 0.64 9.9 0.48 2.01e-20 Red blood cell count; LUSC cis rs2137920 0.891 rs2254628 chr10:50236631 G/C cg27141751 chr10:50231850 C10orf72 0.38 5.73 0.3 2.28e-8 Migraine with aura; LUSC cis rs10740039 0.516 rs2154392 chr10:62317486 G/A cg18175470 chr10:62150864 ANK3 -0.47 -6.94 -0.36 2.01e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs6740322 0.748 rs6544635 chr2:43486704 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -6.51 -0.34 2.75e-10 Coronary artery disease; LUSC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.65 0.3 3.49e-8 Tonsillectomy; LUSC cis rs1577917 1.000 rs6454513 chr6:86720049 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.38 0.42 1.54e-15 Response to antipsychotic treatment; LUSC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg00409905 chr10:38381863 ZNF37A -0.35 -6.03 -0.31 4.4e-9 Extrinsic epigenetic age acceleration; LUSC cis rs6815814 0.861 rs73142654 chr4:38785697 T/A cg06935464 chr4:38784597 TLR10 0.46 5.87 0.31 1.07e-8 Breast cancer; LUSC cis rs7193541 0.640 rs4072222 chr16:74706736 A/C cg01733217 chr16:74700730 RFWD3 1.02 23.02 0.78 6.62e-71 Multiple myeloma; LUSC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg00431813 chr7:1051703 C7orf50 -0.4 -6.29 -0.33 9.7e-10 Longevity;Endometriosis; LUSC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg02675527 chr2:114030824 PAX8;LOC440839 -0.52 -7.13 -0.36 6.38e-12 Renal function-related traits (BUN); LUSC cis rs1215050 0.791 rs165247 chr4:98692399 A/G cg05340658 chr4:99064831 C4orf37 0.44 6.81 0.35 4.42e-11 Waist-to-hip ratio adjusted for body mass index; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26401822 chr12:123459832 ABCB9;OGFOD2 -0.41 -5.95 -0.31 6.95e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg16647868 chr5:131706066 SLC22A5 -0.38 -6.11 -0.32 2.78e-9 Breast cancer; LUSC cis rs7804356 0.953 rs10225700 chr7:26869880 C/T cg03456212 chr7:26904342 SKAP2 -0.56 -6.46 -0.33 3.63e-10 Type 1 diabetes; LUSC cis rs6964587 0.869 rs10250641 chr7:91490746 C/T cg17063962 chr7:91808500 NA 0.48 7.1 0.36 7.45e-12 Breast cancer; LUSC cis rs2463822 1.000 rs2246920 chr11:62104937 T/G cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs9693857 0.520 rs4841163 chr8:9366178 C/G cg15556689 chr8:8085844 FLJ10661 0.46 6.76 0.35 6.25e-11 Systolic blood pressure; LUSC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg12386194 chr3:101231763 SENP7 0.56 7.79 0.39 8.41e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg05082376 chr22:42548792 NA -0.42 -6.29 -0.33 1.01e-9 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25130672 chr12:104850576 CHST11 -0.4 -6.09 -0.32 3.15e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg23788917 chr6:8435910 SLC35B3 0.49 7.22 0.37 3.45e-12 Motion sickness; LUSC cis rs6964587 0.935 rs9770444 chr7:91783162 T/G cg01689657 chr7:91764605 CYP51A1 0.32 5.8 0.3 1.57e-8 Breast cancer; LUSC cis rs4722166 0.564 rs1800797 chr7:22766221 A/G cg05472934 chr7:22766657 IL6 0.52 7.92 0.4 3.5e-14 Lung cancer; LUSC cis rs9650315 0.866 rs35835348 chr8:57201435 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.59 7.31 0.37 1.93e-12 Height; LUSC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg07061783 chr6:25882402 NA -0.61 -8.8 -0.43 7.58e-17 Urate levels; LUSC trans rs6582630 0.519 rs11181294 chr12:38312787 C/T cg06521331 chr12:34319734 NA -0.4 -6.07 -0.32 3.44e-9 Drug-induced liver injury (flucloxacillin); LUSC cis rs6539267 0.748 rs1921953 chr12:106721012 C/T cg00173435 chr12:106696525 TCP11L2 0.47 6.34 0.33 7.48e-10 Tourette syndrome; LUSC cis rs4595586 0.545 rs7958118 chr12:39376685 C/T cg13010199 chr12:38710504 ALG10B 0.4 5.85 0.3 1.16e-8 Morning vs. evening chronotype; LUSC cis rs6496667 0.509 rs6496677 chr15:90990358 A/G cg10434728 chr15:90938212 IQGAP1 0.33 6.25 0.32 1.22e-9 Rheumatoid arthritis; LUSC cis rs13253111 0.583 rs6993376 chr8:28096300 A/C cg26534493 chr8:28060551 NA 0.37 6.76 0.35 6.2e-11 Childhood body mass index; LUSC cis rs300703 0.810 rs72772835 chr2:134554 C/T cg21211680 chr2:198530 NA -0.73 -6.68 -0.34 9.84e-11 Blood protein levels; LUSC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg14343924 chr8:8086146 FLJ10661 -0.43 -6.04 -0.31 4.1e-9 Mood instability; LUSC cis rs2273669 0.504 rs74421833 chr6:109409274 A/G cg05315195 chr6:109294784 ARMC2 -0.54 -5.8 -0.3 1.57e-8 Prostate cancer; LUSC cis rs6690583 0.623 rs1371143 chr1:85455532 C/T cg11262906 chr1:85462892 MCOLN2 0.67 6.75 0.35 6.38e-11 Serum sulfate level; LUSC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.0 0.4 2.09e-14 Alzheimer's disease; LUSC cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.51 0.34 2.82e-10 Coronary artery disease; LUSC cis rs7586879 0.616 rs916485 chr2:25082273 T/C cg04586622 chr2:25135609 ADCY3 0.4 8.36 0.42 1.71e-15 Body mass index; LUSC cis rs4708431 0.540 rs12527674 chr6:168492582 A/G cg02770688 chr6:168491649 NA 0.34 6.41 0.33 4.9e-10 Attention deficit hyperactivity disorder (combined symptoms); LUSC cis rs514406 0.763 rs9988539 chr1:53213884 T/C cg27535305 chr1:53392650 SCP2 0.36 6.66 0.34 1.13e-10 Monocyte count; LUSC cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg10253484 chr15:75165896 SCAMP2 -0.6 -8.32 -0.41 2.29e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg03530756 chr16:3285262 ZNF200 0.46 6.63 0.34 1.3100000000000001e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.17 -0.32 2.02e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6754311 0.628 rs309811 chr2:136625602 A/G cg07169764 chr2:136633963 MCM6 -0.59 -7.8 -0.39 8.24e-14 Mosquito bite size; LUSC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 6.38 0.33 5.94e-10 Personality dimensions; LUSC trans rs3942852 0.955 rs6485809 chr11:48112468 C/T cg15704280 chr7:45808275 SEPT13 -0.54 -6.18 -0.32 1.87e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg03213289 chr20:61660250 NA 0.67 13.93 0.61 4.17e-35 Prostate cancer (SNP x SNP interaction); LUSC cis rs9399135 0.967 rs6915770 chr6:135369214 G/A cg24558204 chr6:135376177 HBS1L 0.58 9.03 0.44 1.38e-17 Red blood cell count; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg15790184 chr11:494944 RNH1 -0.52 -5.9 -0.31 8.96e-9 Body mass index; LUSC cis rs4917300 0.647 rs2201176 chr8:143118987 A/G cg25363559 chr8:143086065 NA -0.34 -7.25 -0.37 2.83e-12 Amyotrophic lateral sclerosis; LUSC cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg05283184 chr6:79620031 NA -0.57 -11.82 -0.54 3.53e-27 Intelligence (multi-trait analysis); LUSC cis rs3812831 0.635 rs6560937 chr13:114945991 C/G cg08824895 chr13:115047677 UPF3A 0.55 8.6 0.43 3.24e-16 Schizophrenia; LUSC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg04733989 chr22:42467013 NAGA 0.62 9.7 0.47 8.94e-20 Schizophrenia; LUSC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg11812906 chr14:75593930 NEK9 -0.65 -11.23 -0.52 4.73e-25 Height; LUSC cis rs1048238 0.506 rs1262788 chr1:16215608 G/C cg22431228 chr1:16359049 CLCNKA 0.41 8.56 0.42 4.09e-16 Systolic blood pressure; LUSC trans rs3756766 0.959 rs4835790 chr5:137744392 T/C cg21075261 chr7:155633421 NA -0.35 -5.98 -0.31 5.85e-9 Schizophrenia; LUSC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.7 -11.59 -0.54 2.48e-26 Systemic lupus erythematosus; LUSC cis rs16910800 0.731 rs7125729 chr11:23181637 A/G cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs2404602 0.967 rs7174096 chr15:77072400 A/G cg22467129 chr15:76604101 ETFA -0.42 -6.6 -0.34 1.57e-10 Blood metabolite levels; LUSC cis rs1728785 0.892 rs4783648 chr16:68558334 C/T cg02972257 chr16:68554789 NA 0.57 6.98 0.36 1.57e-11 Ulcerative colitis; LUSC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg14552801 chr7:65878734 NA 0.4 6.0 0.31 5.21e-9 Aortic root size; LUSC cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.51 7.23 0.37 3.38e-12 Gut microbiome composition (summer); LUSC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.47 6.8 0.35 4.88e-11 Platelet count; LUSC cis rs12545109 0.879 rs7845180 chr8:57324431 C/T cg09654669 chr8:57350985 NA 0.58 8.12 0.41 9.05e-15 Obesity-related traits; LUSC trans rs11039798 0.920 rs12417899 chr11:49017552 G/A cg03929089 chr4:120376271 NA 0.77 6.33 0.33 7.7e-10 Axial length; LUSC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg11752832 chr7:134001865 SLC35B4 0.53 8.0 0.4 2.08e-14 Mean platelet volume; LUSC cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg27129171 chr3:47204927 SETD2 -0.69 -11.55 -0.53 3.35e-26 Colorectal cancer; LUSC cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg12863693 chr15:85201151 NMB 0.34 6.15 0.32 2.27e-9 Schizophrenia; LUSC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg09267113 chr7:98030324 BAIAP2L1 0.38 5.67 0.3 3.04e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg26597838 chr10:835615 NA 0.78 9.46 0.46 5.75e-19 Eosinophil percentage of granulocytes; LUSC cis rs1018836 0.628 rs35816262 chr8:91511017 C/G cg16814680 chr8:91681699 NA -0.71 -10.77 -0.51 2.07e-23 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs1375194 0.582 rs13391166 chr2:33805314 C/T cg04131969 chr2:33951647 MYADML 0.64 9.07 0.44 1.03e-17 Response to antidepressants in depression; LUSC cis rs4363385 0.720 rs1134220 chr1:152976306 T/G cg25856811 chr1:152973957 SPRR3 -0.34 -5.7 -0.3 2.69e-8 Inflammatory skin disease; LUSC cis rs17818399 0.547 rs4952833 chr2:46762034 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.55 -7.06 -0.36 9.51e-12 Height; LUSC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.1 0.61 9.67e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg23029597 chr12:123009494 RSRC2 -0.72 -9.72 -0.47 8.1e-20 Body mass index; LUSC cis rs4319547 0.656 rs3817011 chr12:122819566 C/T cg23029597 chr12:123009494 RSRC2 -0.71 -9.04 -0.44 1.28e-17 Body mass index; LUSC cis rs709400 0.593 rs12898029 chr14:103877884 T/C cg12935359 chr14:103987150 CKB 0.55 8.54 0.42 4.75e-16 Body mass index; LUSC cis rs6500395 1.000 rs4785535 chr16:48707659 A/G cg04672837 chr16:48644449 N4BP1 -0.46 -6.95 -0.36 1.91e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs1335645 0.655 rs61804623 chr1:111650834 T/G cg00321911 chr1:111669324 DRAM2 -0.59 -6.16 -0.32 2.13e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs6967385 0.560 rs4554369 chr7:12356511 C/T cg06484146 chr7:12443880 VWDE 0.5 7.51 0.38 5.42e-13 Response to taxane treatment (placlitaxel); LUSC cis rs7715806 0.500 rs17563995 chr5:75007556 A/G cg19683494 chr5:74908142 NA 0.57 7.76 0.39 1.05e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg08798685 chr6:27730294 NA -0.64 -6.01 -0.31 4.93e-9 Breast cancer; LUSC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg17366294 chr4:99064904 C4orf37 0.57 10.0 0.48 9.46e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg00750074 chr16:89608354 SPG7 -0.56 -9.89 -0.48 2.17e-20 Multiple myeloma (IgH translocation); LUSC cis rs2708377 0.789 rs115164039 chr12:11249393 T/G cg20188490 chr12:11080457 PRH2;PRR4;PRH1 0.78 7.46 0.38 7.47e-13 Bitter taste perception; LUSC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg23093090 chr10:104574429 C10orf26 -0.46 -8.24 -0.41 4.04e-15 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg18904891 chr8:8559673 CLDN23 -0.64 -8.57 -0.42 3.92e-16 Obesity-related traits; LUSC cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg22535103 chr8:58192502 C8orf71 0.78 8.3 0.41 2.6e-15 Developmental language disorder (linguistic errors); LUSC cis rs7208859 0.623 rs11652533 chr17:29060601 A/C cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7528419 0.895 rs599839 chr1:109822166 A/G cg00908766 chr1:109817496 CELSR2 -0.74 -11.21 -0.52 5.65e-25 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; LUSC cis rs9388451 0.772 rs1268064 chr6:126042578 G/A cg05901451 chr6:126070800 HEY2 0.89 16.67 0.67 7.72e-46 Brugada syndrome; LUSC cis rs11122272 0.733 rs2749700 chr1:231522734 A/G cg06096015 chr1:231504339 EGLN1 0.55 9.57 0.46 2.48e-19 Hemoglobin concentration; LUSC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg11663144 chr21:46675770 NA -0.42 -7.24 -0.37 3.03e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs1775715 0.870 rs1755080 chr10:32255195 G/A cg03015672 chr10:32216066 ARHGAP12 0.33 5.69 0.3 2.85e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs17401966 1.000 rs12118323 chr1:10469641 A/G cg19773385 chr1:10388646 KIF1B -0.57 -9.66 -0.47 1.29e-19 Hepatocellular carcinoma; LUSC cis rs77741769 0.529 rs7137504 chr12:121221628 C/T cg02419362 chr12:121203948 SPPL3 0.46 8.56 0.42 4.27e-16 Mean corpuscular volume; LUSC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg00745463 chr17:30367425 LRRC37B 0.79 9.27 0.45 2.31e-18 Hip circumference adjusted for BMI; LUSC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg25726756 chr21:47582351 C21orf56 0.33 5.67 0.3 3.16e-8 Testicular germ cell tumor; LUSC cis rs28386778 1.000 rs2665810 chr17:61970210 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.67 10.57 0.5 1.01e-22 Prudent dietary pattern; LUSC cis rs1729951 0.575 rs361237 chr3:136702414 A/G cg12473912 chr3:136751656 NA 0.4 7.28 0.37 2.48e-12 Neuroticism; LUSC cis rs11098499 0.542 rs10440343 chr4:120309787 G/C cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg25072359 chr17:41440525 NA 0.64 9.05 0.44 1.22e-17 Menopause (age at onset); LUSC trans rs3960554 0.733 rs59170362 chr7:75629267 G/C cg19862616 chr7:65841803 NCRNA00174 0.87 10.19 0.49 2.01e-21 Eotaxin levels; LUSC trans rs11098499 0.955 rs35197422 chr4:120169314 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.14 0.32 2.31e-9 Corneal astigmatism; LUSC cis rs6954274 0.789 rs4725229 chr7:9830571 T/G cg27477025 chr7:9765726 NA -0.38 -5.69 -0.3 2.76e-8 Subjective well-being; LUSC cis rs7640424 0.819 rs34937412 chr3:107829484 G/C cg09227934 chr3:107805635 CD47 -0.44 -6.87 -0.35 3.17e-11 Body mass index; LUSC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg07703079 chr11:430292 ANO9 0.58 6.41 0.33 4.83e-10 Body mass index; LUSC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg19592336 chr6:28129416 ZNF389 0.51 6.66 0.34 1.13e-10 Depression; LUSC cis rs11971779 0.838 rs11764161 chr7:139115198 T/C cg07862535 chr7:139043722 LUC7L2 0.71 8.46 0.42 8.53e-16 Diisocyanate-induced asthma; LUSC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg05368731 chr17:41323189 NBR1 0.93 15.79 0.65 2.51e-42 Menopause (age at onset); LUSC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg24110177 chr3:50126178 RBM5 -0.6 -10.08 -0.48 4.76e-21 Body mass index; LUSC cis rs859767 0.741 rs11898084 chr2:135428054 T/C cg12500956 chr2:135428796 TMEM163 -0.27 -6.04 -0.31 4.1e-9 Neuroticism; LUSC cis rs9648716 0.515 rs62487920 chr7:140491258 C/T cg23214464 chr7:140373596 ADCK2 0.63 5.66 0.3 3.31e-8 Type 2 diabetes; LUSC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18404041 chr3:52824283 ITIH1 -0.62 -12.01 -0.55 7.56e-28 Bipolar disorder; LUSC cis rs11122272 0.735 rs2808604 chr1:231538916 T/C cg06096015 chr1:231504339 EGLN1 0.56 9.73 0.47 7.59e-20 Hemoglobin concentration; LUSC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg24829409 chr8:58192753 C8orf71 -0.58 -6.13 -0.32 2.44e-9 Developmental language disorder (linguistic errors); LUSC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg03709012 chr19:19516395 GATAD2A 0.87 14.68 0.63 5.6e-38 Tonsillectomy; LUSC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg23758822 chr17:41437982 NA 1.06 20.18 0.74 8.67e-60 Menopause (age at onset); LUSC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg02569458 chr12:86230093 RASSF9 0.57 9.64 0.47 1.41e-19 Major depressive disorder; LUSC cis rs9534288 0.731 rs2404730 chr13:46617381 G/A cg15192986 chr13:46630673 CPB2 -0.66 -10.45 -0.5 2.75e-22 Blood protein levels; LUSC cis rs13108904 0.870 rs3733338 chr4:1241472 G/A cg19318889 chr4:1322082 MAEA 0.45 7.37 0.37 1.39e-12 Obesity-related traits; LUSC cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.17 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg22029157 chr1:209979665 IRF6 0.51 8.14 0.41 7.85e-15 Monobrow; LUSC cis rs4930103 0.935 rs11042167 chr11:2020901 G/A cg23202291 chr11:1979235 NA 0.39 6.09 0.32 3.14e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs9952991 0.941 rs34920518 chr18:12783086 A/G cg23598886 chr18:12777645 NA -0.6 -5.9 -0.31 8.85e-9 Inflammatory skin disease; LUSC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg23172400 chr8:95962367 TP53INP1 -0.38 -7.71 -0.39 1.46e-13 Type 2 diabetes; LUSC cis rs2224391 0.628 rs2773314 chr6:5253800 C/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.5 -6.76 -0.35 6.08e-11 Height; LUSC cis rs62458065 0.513 rs10268149 chr7:32575499 T/C cg20159608 chr7:32802032 NA -0.71 -9.2 -0.45 4.05e-18 Metabolite levels (HVA/MHPG ratio); LUSC cis rs7103648 0.966 rs1377416 chr11:47416746 C/T cg20307385 chr11:47447363 PSMC3 0.97 18.8 0.72 2.73e-54 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs9814567 0.929 rs13316205 chr3:134223563 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.54 -0.6 1.29e-33 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.29 -0.33 9.83e-10 Lung cancer; LUSC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg19680485 chr15:31195859 MTMR15 0.5 6.58 0.34 1.86e-10 Huntington's disease progression; LUSC cis rs2933343 0.729 rs789228 chr3:128601050 A/G cg11901034 chr3:128598214 ACAD9 -0.4 -6.11 -0.32 2.74e-9 IgG glycosylation; LUSC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg23985595 chr17:80112537 CCDC57 0.31 5.82 0.3 1.38e-8 Life satisfaction; LUSC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg22920501 chr2:26401640 FAM59B -0.81 -12.43 -0.56 2.09e-29 Gut microbiome composition (summer); LUSC cis rs1451375 0.669 rs4512339 chr7:50646977 C/T cg18232548 chr7:50535776 DDC -0.51 -7.61 -0.38 2.85e-13 Malaria; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05926943 chr16:50100517 HEATR3 0.74 6.18 0.32 1.92e-9 Cognitive performance; LUSC cis rs3750965 1.000 rs3750965 chr11:68840160 A/G cg06818126 chr11:68850279 TPCN2 -0.46 -6.68 -0.34 9.95e-11 Hair color; LUSC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg16680214 chr1:154839983 KCNN3 0.5 9.32 0.45 1.68e-18 Prostate cancer; LUSC cis rs6545883 0.868 rs7608483 chr2:61836235 A/C cg15711740 chr2:61764176 XPO1 -0.46 -7.37 -0.37 1.33e-12 Tuberculosis; LUSC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg16479474 chr6:28041457 NA 0.33 5.72 0.3 2.36e-8 Parkinson's disease; LUSC cis rs9921222 0.500 rs11648673 chr16:377794 G/A cg15001381 chr16:403314 AXIN1 0.34 6.25 0.32 1.24e-9 Bone mineral density (spine);Bone mineral density; LUSC cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg13770153 chr20:60521292 NA -0.61 -8.39 -0.42 1.43e-15 Body mass index; LUSC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg24562669 chr7:97807699 LMTK2 0.36 6.29 0.33 9.85e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg11366901 chr6:160182831 ACAT2 0.81 11.23 0.52 4.73e-25 Age-related macular degeneration (geographic atrophy); LUSC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg03806693 chr22:41940476 POLR3H 0.99 14.04 0.61 1.61e-35 Vitiligo; LUSC cis rs11971779 0.584 rs6962029 chr7:139034719 T/C cg07862535 chr7:139043722 LUC7L2 0.53 6.63 0.34 1.36e-10 Diisocyanate-induced asthma; LUSC cis rs7246657 0.823 rs4802236 chr19:37919246 A/G cg23950597 chr19:37808831 NA -0.63 -7.34 -0.37 1.66e-12 Coronary artery calcification; LUSC cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 7.5 0.38 5.82e-13 Colorectal cancer; LUSC cis rs7481584 0.624 rs428726 chr11:3046201 G/A cg25174290 chr11:3078921 CARS -0.42 -6.28 -0.32 1.06e-9 Calcium levels; LUSC cis rs4654899 1.000 rs7554770 chr1:21481361 A/T cg01072550 chr1:21505969 NA -0.55 -8.5 -0.42 6.28e-16 Superior frontal gyrus grey matter volume; LUSC trans rs34421088 0.560 rs2248325 chr8:11396874 A/G cg08975724 chr8:8085496 FLJ10661 -0.51 -7.59 -0.38 3.13e-13 Neuroticism; LUSC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg00074818 chr8:8560427 CLDN23 0.58 9.88 0.48 2.23e-20 Obesity-related traits; LUSC cis rs7903847 0.642 rs2275089 chr10:99141205 A/G cg20016023 chr10:99160130 RRP12 -0.33 -8.04 -0.4 1.57e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs7215564 0.908 rs34932625 chr17:78653155 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.05 0.31 3.85e-9 Myopia (pathological); LUSC cis rs977987 0.705 rs4888377 chr16:75325686 C/G cg03315344 chr16:75512273 CHST6 0.5 8.97 0.44 2.2e-17 Dupuytren's disease; LUSC cis rs12618769 0.597 rs3754883 chr2:99129451 T/C cg10123293 chr2:99228465 UNC50 0.46 7.53 0.38 4.73e-13 Bipolar disorder; LUSC cis rs1044826 1.000 rs1044826 chr3:139073011 A/G cg00490450 chr3:139108681 COPB2 -0.58 -7.62 -0.38 2.73e-13 Obesity-related traits; LUSC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg05313129 chr8:58192883 C8orf71 -0.51 -5.91 -0.31 8.63e-9 Developmental language disorder (linguistic errors); LUSC cis rs7264396 0.887 rs8116304 chr20:34054409 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.65 -0.34 1.18e-10 Total cholesterol levels; LUSC cis rs7089973 0.604 rs11196929 chr10:116582080 G/C cg03647239 chr10:116582469 FAM160B1 0.45 7.21 0.37 3.78e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -10.27 -0.49 1.09e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4243830 1.000 rs11809957 chr1:6584420 C/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.9 8.76 0.43 9.71e-17 Body mass index; LUSC cis rs62458065 0.513 rs7805536 chr7:32573570 T/C cg20159608 chr7:32802032 NA -0.71 -9.2 -0.45 4.05e-18 Metabolite levels (HVA/MHPG ratio); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19252529 chr3:170075940 SKIL -0.41 -6.14 -0.32 2.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9549367 0.789 rs2287247 chr13:113889212 A/G cg18105134 chr13:113819100 PROZ -0.67 -9.51 -0.46 3.79e-19 Platelet distribution width; LUSC cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg13010199 chr12:38710504 ALG10B -0.62 -10.36 -0.49 5.5e-22 Heart rate; LUSC cis rs9463078 0.510 rs4714832 chr6:44978183 T/C cg25276700 chr6:44698697 NA 0.29 6.03 0.31 4.31e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg21535247 chr6:8435926 SLC35B3 0.57 8.79 0.43 8.02e-17 Motion sickness; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg23296392 chr10:72648329 PCBD1 0.7 6.0 0.31 5.25e-9 Cognitive performance; LUSC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg06656553 chr16:89960601 TCF25 -0.65 -5.7 -0.3 2.63e-8 Skin colour saturation; LUSC cis rs9811920 0.683 rs4928230 chr3:99661963 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.35 -6.66 -0.34 1.14e-10 Axial length; LUSC cis rs72634258 0.554 rs10462018 chr1:7879627 C/T cg26816564 chr1:7831052 VAMP3 0.84 12.37 0.56 3.44e-29 Inflammatory bowel disease; LUSC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg06637938 chr14:75390232 RPS6KL1 -0.53 -8.54 -0.42 4.95e-16 Height; LUSC cis rs981844 0.683 rs1037655 chr4:154750408 A/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.32 -0.33 8.22e-10 Response to statins (LDL cholesterol change); LUSC cis rs3931020 0.688 rs405445 chr1:75221150 C/T cg21906852 chr1:75198582 TYW3;CRYZ -0.43 -5.72 -0.3 2.33e-8 Resistin levels; LUSC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11890956 chr21:40555474 PSMG1 1.03 20.55 0.75 2.97e-61 Cognitive function; LUSC cis rs2108225 0.934 rs2190392 chr7:107452685 T/C cg18560240 chr7:107437656 SLC26A3 -0.43 -6.54 -0.34 2.27e-10 Ulcerative colitis; LUSC cis rs78456975 1.000 rs4073861 chr2:1563611 G/A cg12573674 chr2:1569213 NA -0.55 -6.16 -0.32 2.15e-9 Placebo response in major depressive disorder (% change in symptom score); LUSC cis rs5756813 0.688 rs12484064 chr22:38126746 C/A cg06521852 chr22:38141419 TRIOBP 0.4 5.91 0.31 8.58e-9 Optic cup area;Vertical cup-disc ratio; LUSC cis rs6733011 0.508 rs4851173 chr2:99520608 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -6.01 -0.31 4.78e-9 Bipolar disorder; LUSC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg03433033 chr1:76189801 ACADM 0.71 9.37 0.46 1.11e-18 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs4974559 0.793 rs10025954 chr4:1351382 C/T cg02980000 chr4:1222292 CTBP1 0.7 7.06 0.36 9.72e-12 Systolic blood pressure; LUSC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -8.44 -0.42 9.51e-16 Cystic fibrosis severity; LUSC cis rs4363385 0.782 rs4845515 chr1:153003871 G/T cg00922841 chr1:152955080 SPRR1A -0.4 -7.08 -0.36 8.6e-12 Inflammatory skin disease; LUSC cis rs9875589 0.509 rs1601868 chr3:14065450 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 7.12 0.36 6.54e-12 Ovarian reserve; LUSC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg24549020 chr5:56110836 MAP3K1 0.47 5.69 0.3 2.8e-8 Initial pursuit acceleration; LUSC cis rs477692 0.905 rs563859 chr10:131417586 T/C cg05714579 chr10:131428358 MGMT 0.53 8.05 0.4 1.43e-14 Response to temozolomide; LUSC cis rs3812762 0.957 rs10160684 chr11:8775419 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.36 6.25 0.32 1.27e-9 Hypospadias; LUSC cis rs12421382 0.614 rs12418763 chr11:109390360 C/T cg16359550 chr11:109292809 C11orf87 0.32 5.78 0.3 1.67e-8 Schizophrenia; LUSC cis rs12681288 0.862 rs2701899 chr8:1019581 G/A cg04851639 chr8:1020857 NA -0.4 -8.23 -0.41 4.31e-15 Schizophrenia; LUSC cis rs5769707 0.740 rs79946167 chr22:50017556 G/A cg20744362 chr22:50050164 C22orf34 0.28 5.66 0.3 3.18e-8 Monocyte count;Monocyte percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg13903809 chr12:93964785 SOCS2 -0.43 -6.43 -0.33 4.29e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg21535247 chr6:8435926 SLC35B3 0.58 8.9 0.44 3.49e-17 Motion sickness; LUSC cis rs2522056 1.000 rs2057655 chr5:131807624 A/G cg24060327 chr5:131705240 SLC22A5 -0.42 -6.0 -0.31 5.05e-9 Lymphocyte counts;Fibrinogen; LUSC cis rs4948275 0.550 rs10994742 chr10:63132240 A/T cg26785954 chr10:63212815 TMEM26 -0.37 -5.64 -0.3 3.56e-8 Night sleep phenotypes; LUSC cis rs2692947 0.832 rs2692954 chr2:96683378 T/G cg22654517 chr2:96458247 NA 0.34 6.43 0.33 4.4e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg03233332 chr7:66118400 NA -0.4 -5.92 -0.31 8.15e-9 Aortic root size; LUSC trans rs7843479 0.511 rs4379446 chr8:21777595 C/G cg04681394 chr10:134997386 KNDC1 0.28 6.02 0.31 4.57e-9 Mean corpuscular volume; LUSC cis rs9309473 0.660 rs11679594 chr2:73779507 G/A cg20560298 chr2:73613845 ALMS1 -0.53 -6.22 -0.32 1.46e-9 Metabolite levels; LUSC cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg12219531 chr12:120966889 COQ5 0.61 8.36 0.42 1.75e-15 High light scatter reticulocyte count; LUSC cis rs9341808 0.718 rs9448899 chr6:80845864 G/A cg08355045 chr6:80787529 NA 0.57 10.03 0.48 7.17e-21 Sitting height ratio; LUSC cis rs9436747 0.546 rs10749753 chr1:65998467 A/G cg14976592 chr1:65886160 LEPROT;LEPR -0.45 -6.19 -0.32 1.73e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; LUSC cis rs2629540 0.847 rs12763093 chr10:126395688 C/G cg08799069 chr10:126477246 METTL10 -0.6 -8.33 -0.41 2.12e-15 Cocaine dependence; LUSC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg24562669 chr7:97807699 LMTK2 0.35 6.17 0.32 2.01e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 13.4 0.59 4.48e-33 Alzheimer's disease; LUSC cis rs73198271 0.562 rs964772 chr8:8651306 A/G cg01851573 chr8:8652454 MFHAS1 0.6 8.29 0.41 2.81e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2124969 0.527 rs56040145 chr2:160983850 A/G cg03641300 chr2:160917029 PLA2R1 -0.48 -5.79 -0.3 1.6e-8 Waist circumference adjusted for body mass index; LUSC cis rs3126085 0.877 rs2338431 chr1:152169305 A/G cg26876637 chr1:152193138 HRNR 0.45 6.36 0.33 6.58e-10 Atopic dermatitis; LUSC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg00677455 chr12:58241039 CTDSP2 -0.71 -10.87 -0.51 8.98e-24 Multiple sclerosis; LUSC cis rs11098499 0.663 rs28369503 chr4:120238925 G/A cg24375607 chr4:120327624 NA 0.76 11.87 0.54 2.32e-27 Corneal astigmatism; LUSC cis rs9549260 0.755 rs17061503 chr13:41246758 A/G cg21288729 chr13:41239152 FOXO1 -0.63 -9.83 -0.47 3.41e-20 Red blood cell count; LUSC cis rs829880 0.558 rs249821 chr12:98897811 T/C cg25150519 chr12:98850993 NA 0.44 5.65 0.3 3.52e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs11122272 0.735 rs2808601 chr1:231536571 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.71 -0.47 8.8e-20 Hemoglobin concentration; LUSC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg27286337 chr10:134555280 INPP5A 0.92 11.97 0.55 1.05e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg11344533 chr11:111475393 SIK2 -0.48 -6.58 -0.34 1.78e-10 Primary sclerosing cholangitis; LUSC cis rs9300255 0.664 rs12316131 chr12:123817796 T/C cg13010344 chr12:123464640 ARL6IP4 0.5 6.37 0.33 6.4e-10 Neutrophil percentage of white cells; LUSC cis rs6960043 1.000 rs6960043 chr7:15052860 C/T cg19272540 chr7:15055459 NA 0.3 7.22 0.37 3.59e-12 Type 2 diabetes; LUSC cis rs59918340 1.000 rs59918340 chr8:142232256 A/G cg23750338 chr8:142222470 SLC45A4 0.48 8.75 0.43 1.1e-16 Immature fraction of reticulocytes; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.59 6.49 0.33 3.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg23505145 chr19:12996616 KLF1 0.64 11.0 0.52 3.08e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs2073300 0.609 rs6137951 chr20:23429459 T/C cg12062639 chr20:23401060 NAPB 0.93 8.13 0.41 8.57e-15 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs7772486 0.875 rs1960885 chr6:146325930 G/T cg13319975 chr6:146136371 FBXO30 -0.47 -7.05 -0.36 1.04e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg05347473 chr6:146136440 FBXO30 0.4 6.91 0.35 2.48e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs7824557 0.767 rs2164273 chr8:11168499 A/G cg27411982 chr8:10470053 RP1L1 0.37 5.86 0.31 1.14e-8 Retinal vascular caliber; LUSC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.74 -10.84 -0.51 1.12e-23 Multiple sclerosis; LUSC cis rs2274273 0.553 rs56166765 chr14:55738018 T/C cg04306507 chr14:55594613 LGALS3 0.49 9.81 0.47 4.08e-20 Protein biomarker; LUSC cis rs4969178 1.000 rs7212201 chr17:76393896 C/A cg05887092 chr17:76393375 PGS1 0.53 9.51 0.46 3.84e-19 HDL cholesterol levels; LUSC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg14552801 chr7:65878734 NA -0.38 -5.89 -0.31 9.6e-9 Aortic root size; LUSC cis rs9325144 0.555 rs6582576 chr12:38701230 C/T cg26384229 chr12:38710491 ALG10B -0.66 -10.3 -0.49 8.54e-22 Morning vs. evening chronotype; LUSC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg18230493 chr5:56204884 C5orf35 -0.88 -13.27 -0.59 1.44e-32 Initial pursuit acceleration; LUSC trans rs724744 0.742 rs1205944 chr6:22356823 T/C cg13807341 chr11:118445984 ARCN1 -0.36 -6.07 -0.32 3.5e-9 Basophil percentage of granulocytes;Basophil percentage of white cells; LUSC cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg21535247 chr6:8435926 SLC35B3 0.59 9.03 0.44 1.43e-17 Motion sickness; LUSC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.98 -13.22 -0.59 2.24e-32 Alzheimer's disease; LUSC cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.09 -0.48 4.66e-21 Developmental language disorder (linguistic errors); LUSC cis rs2559856 1.000 rs2695282 chr12:102089502 A/G cg12924262 chr12:102091054 CHPT1 -0.44 -6.17 -0.32 2.02e-9 Blood protein levels; LUSC cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg24060327 chr5:131705240 SLC22A5 -0.38 -6.26 -0.32 1.21e-9 Blood metabolite levels; LUSC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.93 -0.72 8.57e-55 Height; LUSC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg15839431 chr19:19639596 YJEFN3 0.42 5.73 0.3 2.3e-8 Tonsillectomy; LUSC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg25554036 chr4:6271136 WFS1 0.62 12.64 0.57 3.5e-30 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs17095355 0.748 rs2501577 chr10:111846687 C/T cg00817464 chr10:111662876 XPNPEP1 0.56 7.23 0.37 3.34e-12 Biliary atresia; LUSC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg07167872 chr1:205819463 PM20D1 0.99 23.0 0.78 8.03e-71 Menarche (age at onset); LUSC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg24060327 chr5:131705240 SLC22A5 0.6 9.92 0.48 1.71e-20 Breast cancer; LUSC cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg08085267 chr17:45401833 C17orf57 0.54 8.85 0.44 5.17e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 10.92 0.51 6.24e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs6840360 0.571 rs17275536 chr4:152498625 C/T cg22705602 chr4:152727874 NA -0.35 -7.03 -0.36 1.16e-11 Intelligence (multi-trait analysis); LUSC cis rs1775715 0.870 rs7912121 chr10:32228995 T/G cg18675610 chr10:32216311 ARHGAP12 0.28 6.19 0.32 1.81e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs11098499 0.954 rs3890049 chr4:120326283 T/A cg24375607 chr4:120327624 NA 0.79 11.75 0.54 6.4e-27 Corneal astigmatism; LUSC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg24642844 chr7:1081250 C7orf50 -0.81 -11.07 -0.52 1.75e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg23711669 chr6:146136114 FBXO30 0.87 16.06 0.66 2.16e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg07606381 chr6:8435919 SLC35B3 0.73 12.14 0.55 2.48e-28 Motion sickness; LUSC cis rs738322 0.640 rs738321 chr22:38568833 C/G cg17652424 chr22:38574118 PLA2G6 -0.27 -5.69 -0.3 2.81e-8 Cutaneous nevi; LUSC cis rs2273669 0.667 rs74582170 chr6:109312689 C/T cg05315195 chr6:109294784 ARMC2 -0.55 -6.2 -0.32 1.62e-9 Prostate cancer; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg25942484 chr19:4941818 UHRF1 -0.39 -6.12 -0.32 2.65e-9 N-glycan levels; LUSC cis rs7829975 0.681 rs2271342 chr8:8643938 C/T cg08975724 chr8:8085496 FLJ10661 0.49 7.28 0.37 2.35e-12 Mood instability; LUSC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg26408565 chr15:76604113 ETFA -0.49 -7.88 -0.4 4.81e-14 Blood metabolite levels; LUSC cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg23158103 chr7:148848205 ZNF398 -0.4 -6.21 -0.32 1.62e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs4065321 0.522 rs34648856 chr17:38149411 G/A cg17467752 chr17:38218738 THRA -0.5 -7.05 -0.36 1.05e-11 White blood cell count (basophil);White blood cell count; LUSC cis rs11190604 1.000 rs2273695 chr10:102259568 A/G cg16342193 chr10:102329863 NA -0.33 -6.06 -0.31 3.64e-9 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7945705 0.875 rs4929914 chr11:8824388 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -9.94 -0.48 1.46e-20 Hemoglobin concentration; LUSC trans rs853679 0.607 rs56075693 chr6:28290328 T/G cg06606381 chr12:133084897 FBRSL1 -0.99 -9.27 -0.45 2.45e-18 Depression; LUSC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg13939156 chr17:80058883 NA -0.32 -6.29 -0.33 1.01e-9 Life satisfaction; LUSC cis rs1018697 0.966 rs6584526 chr10:104566241 G/C cg04362960 chr10:104952993 NT5C2 0.51 7.07 0.36 9.23e-12 Colorectal adenoma (advanced); LUSC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg09491104 chr22:46646882 C22orf40 -0.73 -6.61 -0.34 1.56e-10 LDL cholesterol;Cholesterol, total; LUSC trans rs2243480 0.803 rs403089 chr7:65517723 T/C cg10756647 chr7:56101905 PSPH 0.85 8.22 0.41 4.44e-15 Diabetic kidney disease; LUSC cis rs7089973 0.604 rs11196937 chr10:116589500 G/C cg25233709 chr10:116636983 FAM160B1 0.37 6.59 0.34 1.69e-10 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs239198 0.578 rs11155708 chr6:101292189 G/A cg09795085 chr6:101329169 ASCC3 0.44 6.27 0.32 1.13e-9 Menarche (age at onset); LUSC trans rs372883 0.580 rs2254038 chr21:30745722 C/T cg14791747 chr16:20752902 THUMPD1 -0.43 -6.15 -0.32 2.24e-9 Pancreatic cancer; LUSC cis rs1376303 0.643 rs2060730 chr7:32968342 T/C cg06627557 chr7:32535165 LSM5;AVL9 -0.66 -5.73 -0.3 2.28e-8 Intelligence (multi-trait analysis); LUSC trans rs11976180 1.000 rs6464574 chr7:143748257 G/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.38 -6.13 -0.32 2.43e-9 Obesity-related traits; LUSC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg15316289 chr22:50310904 ALG12;CRELD2 0.4 5.67 0.3 3.1e-8 Schizophrenia; LUSC cis rs7927592 0.513 rs608343 chr11:68196830 T/C cg20283391 chr11:68216788 NA -0.5 -7.14 -0.36 5.81e-12 Total body bone mineral density; LUSC cis rs72772090 0.710 rs17400741 chr5:96066576 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -7.43 -0.38 9.39e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg13010199 chr12:38710504 ALG10B 0.7 10.81 0.51 1.44e-23 Bladder cancer; LUSC cis rs13385 0.769 rs7710268 chr5:139576347 T/C cg26211634 chr5:139558579 C5orf32 0.44 6.59 0.34 1.76e-10 Atrial fibrillation; LUSC cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg22709100 chr7:91322751 NA 0.39 5.66 0.3 3.25e-8 Breast cancer; LUSC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.43 7.18 0.37 4.53e-12 Personality dimensions; LUSC cis rs11155671 0.530 rs7757984 chr6:150208651 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.75 -0.3 2e-8 Testicular germ cell tumor; LUSC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 12.29 0.56 6.69e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg23711669 chr6:146136114 FBXO30 0.87 16.09 0.66 1.58e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg03667269 chr22:22090129 YPEL1 -0.45 -6.52 -0.34 2.61e-10 Electrocardiographic conduction measures; LUSC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.85 -0.3 1.19e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg05855489 chr10:104503620 C10orf26 0.56 9.02 0.44 1.52e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs4285028 0.948 rs12637351 chr3:121694412 A/G cg11130432 chr3:121712080 ILDR1 0.66 10.01 0.48 8.2e-21 Multiple sclerosis; LUSC cis rs870825 0.929 rs871254 chr4:185589226 G/C cg04058563 chr4:185651563 MLF1IP 0.83 10.8 0.51 1.6e-23 Blood protein levels; LUSC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -10.55 -0.5 1.19e-22 Bipolar disorder and schizophrenia; LUSC cis rs7584330 0.738 rs4402703 chr2:238374957 T/A cg16989719 chr2:238392110 NA -0.38 -6.6 -0.34 1.61e-10 Prostate cancer; LUSC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg00684032 chr4:1343700 KIAA1530 0.37 6.47 0.33 3.48e-10 Obesity-related traits; LUSC cis rs950169 0.887 rs71395453 chr15:85113490 G/C cg17173187 chr15:85201210 NMB 0.35 6.26 0.32 1.19e-9 Schizophrenia; LUSC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg10360139 chr7:1886902 MAD1L1 -0.45 -6.94 -0.35 2.08e-11 Bipolar disorder and schizophrenia; LUSC cis rs2235642 0.891 rs2281231 chr16:1601879 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.45 0.33 3.94e-10 Coronary artery disease; LUSC cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg26384229 chr12:38710491 ALG10B 0.9 15.61 0.65 1.25e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg11645453 chr3:52864694 ITIH4 0.32 7.46 0.38 7.53e-13 Bipolar disorder; LUSC cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg07606381 chr6:8435919 SLC35B3 0.74 12.52 0.57 9.53e-30 Motion sickness; LUSC cis rs6940638 1.000 rs12215241 chr6:27023081 G/A cg09904177 chr6:26538194 HMGN4 -0.5 -5.76 -0.3 1.9e-8 Intelligence (multi-trait analysis); LUSC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg05340658 chr4:99064831 C4orf37 0.67 11.48 0.53 5.96e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs1395 0.744 rs11686131 chr2:27508710 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 6.18 0.32 1.86e-9 Blood metabolite levels; LUSC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11890956 chr21:40555474 PSMG1 0.97 17.42 0.69 8.69e-49 Cognitive function; LUSC cis rs1865760 0.892 rs2328903 chr6:25935765 T/C cg16482183 chr6:26056742 HIST1H1C 0.45 6.46 0.33 3.67e-10 Height; LUSC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg07167872 chr1:205819463 PM20D1 -0.49 -6.89 -0.35 2.75e-11 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.81 12.19 0.55 1.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs45509595 0.556 rs34409918 chr6:27685348 A/G cg01620082 chr3:125678407 NA -0.78 -7.21 -0.37 3.82e-12 Breast cancer; LUSC cis rs4466137 0.953 rs6869030 chr5:83007311 C/T cg16102102 chr5:83017553 HAPLN1 -0.87 -13.31 -0.59 9.83e-33 Prostate cancer; LUSC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.62 10.63 0.5 6.47e-23 Menopause (age at onset); LUSC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.62 -0.39 2.57e-13 Aortic root size; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg26354017 chr1:205819088 PM20D1 0.85 15.1 0.64 1.21e-39 Menarche (age at onset); LUSC cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg19875535 chr5:140030758 IK -0.54 -8.9 -0.44 3.63e-17 Depressive symptoms (multi-trait analysis); LUSC cis rs2629540 0.889 rs17624662 chr10:126408146 A/C cg08799069 chr10:126477246 METTL10 0.6 8.23 0.41 4.3e-15 Cocaine dependence; LUSC cis rs1997103 1.000 rs2140915 chr7:55410699 G/C cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7312933 0.645 rs11181404 chr12:42683840 T/C cg17420585 chr12:42539391 GXYLT1 -0.33 -6.25 -0.32 1.28e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg01879757 chr17:41196368 BRCA1 -0.46 -6.92 -0.35 2.26e-11 Menopause (age at onset); LUSC cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg08085267 chr17:45401833 C17orf57 -0.6 -9.97 -0.48 1.12e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg18479299 chr3:125709523 NA -0.5 -5.79 -0.3 1.6e-8 Blood pressure (smoking interaction); LUSC cis rs41271473 0.948 rs11803118 chr1:228826831 A/G cg16512390 chr1:228756714 NA 0.53 6.22 0.32 1.49e-9 Chronic lymphocytic leukemia; LUSC cis rs714027 1.000 rs714027 chr22:30577771 A/G cg11564601 chr22:30592435 NA 0.37 6.86 0.35 3.25e-11 Lymphocyte counts; LUSC cis rs8060686 0.544 rs1124993 chr16:68114626 T/C cg05110241 chr16:68378359 PRMT7 -0.51 -5.98 -0.31 5.8e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs2018683 0.707 rs2391717 chr7:28971162 G/C cg19402173 chr7:128379420 CALU -0.46 -7.07 -0.36 9.25e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg19717773 chr7:2847554 GNA12 -0.35 -5.86 -0.31 1.12e-8 Height; LUSC cis rs12477438 0.765 rs17708262 chr2:99696313 T/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.87 -12.87 -0.58 4.63e-31 Chronic sinus infection; LUSC cis rs9928842 0.771 rs8059190 chr16:75260797 T/A cg09066997 chr16:75300724 BCAR1 0.49 6.22 0.32 1.48e-9 Alcoholic chronic pancreatitis; LUSC trans rs2727020 0.595 rs10839286 chr11:49497063 C/A cg03929089 chr4:120376271 NA -0.99 -17.57 -0.69 2.14e-49 Coronary artery disease; LUSC cis rs2273669 0.504 rs75555274 chr6:109478385 G/A cg05315195 chr6:109294784 ARMC2 -0.55 -5.85 -0.3 1.18e-8 Prostate cancer; LUSC cis rs9905704 0.918 rs302858 chr17:56692800 G/T cg12560992 chr17:57184187 TRIM37 0.55 7.74 0.39 1.19e-13 Testicular germ cell tumor; LUSC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg13010344 chr12:123464640 ARL6IP4 -0.44 -5.98 -0.31 5.62e-9 Neutrophil percentage of white cells; LUSC cis rs2625529 0.526 rs6494997 chr15:72560642 C/T cg16672083 chr15:72433130 SENP8 0.47 7.8 0.39 7.96e-14 Red blood cell count; LUSC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg07157834 chr1:205819609 PM20D1 0.53 8.67 0.43 1.91e-16 Menarche (age at onset); LUSC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.44 -8.01 -0.4 1.96e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs6690583 0.623 rs7540706 chr1:85534645 A/G cg11262906 chr1:85462892 MCOLN2 -0.67 -6.03 -0.31 4.24e-9 Serum sulfate level; LUSC cis rs977987 0.778 rs2865528 chr16:75455942 T/C cg04384234 chr16:75411784 CFDP1 -0.45 -7.4 -0.38 1.14e-12 Dupuytren's disease; LUSC trans rs1027730 1.000 rs1472747 chr8:94081031 C/T cg20324262 chr19:12958871 MAST1 -0.56 -5.97 -0.31 6.21e-9 Attention deficit hyperactivity disorder; LUSC cis rs9395066 0.545 rs4714828 chr6:44846008 A/G cg25276700 chr6:44698697 NA 0.3 6.01 0.31 4.92e-9 Height; LUSC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg04944784 chr2:26401820 FAM59B -0.69 -9.82 -0.47 3.57e-20 Gut microbiome composition (summer); LUSC cis rs7572644 0.640 rs12464988 chr2:28058226 C/T cg27432699 chr2:27873401 GPN1 0.52 6.95 0.36 1.94e-11 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6692729 0.966 rs6697431 chr1:227015198 C/T cg10327440 chr1:227177885 CDC42BPA 0.48 6.96 0.36 1.81e-11 Electrodermal activity; LUSC cis rs10751667 0.621 rs7394862 chr11:927500 T/C ch.11.42038R chr11:967971 AP2A2 0.41 6.11 0.32 2.78e-9 Alzheimer's disease (late onset); LUSC cis rs7818345 0.967 rs6992893 chr8:19287504 G/A cg11303988 chr8:19266685 CSGALNACT1 0.36 6.96 0.36 1.8e-11 Language performance in older adults (adjusted for episodic memory); LUSC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg00166722 chr3:10149974 C3orf24 0.61 8.64 0.43 2.44e-16 Alzheimer's disease; LUSC trans rs2797160 1.000 rs1777183 chr6:126011995 A/C cg05039488 chr6:79577232 IRAK1BP1 0.44 6.6 0.34 1.66e-10 Endometrial cancer; LUSC cis rs59918340 0.738 rs3739235 chr8:142229145 A/G cg23750338 chr8:142222470 SLC45A4 0.58 11.3 0.53 2.65e-25 Immature fraction of reticulocytes; LUSC cis rs12594515 1.000 rs6493169 chr15:45986994 A/G cg06207120 chr15:45996521 NA -0.4 -6.27 -0.32 1.1e-9 Waist circumference;Weight; LUSC cis rs2857891 0.817 rs2638101 chr11:6969131 G/A cg14883916 chr11:6947541 ZNF215 0.44 5.86 0.31 1.12e-8 Response to cytadine analogues (cytosine arabinoside); LUSC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs11112613 0.818 rs117644588 chr12:106022040 G/C cg03607813 chr12:105948248 NA 0.75 9.13 0.45 6.82e-18 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs2841277 0.646 rs2819419 chr14:105406238 A/C cg21017887 chr14:105400489 NA 0.67 12.39 0.56 2.8e-29 Rheumatoid arthritis; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg03130149 chr11:3819041 PGAP2;NUP98 0.44 6.14 0.32 2.31e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg10150615 chr22:24372951 LOC391322 -0.34 -5.75 -0.3 2.02e-8 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2204008 0.666 rs67792345 chr12:38204698 T/C cg13010199 chr12:38710504 ALG10B 0.7 10.59 0.5 8.81e-23 Bladder cancer; LUSC cis rs2540226 0.844 rs17478972 chr2:39995172 A/G cg23576258 chr2:39999331 THUMPD2 0.34 5.78 0.3 1.71e-8 Personality dimensions; LUSC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.92e-10 Developmental language disorder (linguistic errors); LUSC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg07677032 chr17:61819896 STRADA 0.55 9.11 0.45 8.03e-18 Prudent dietary pattern; LUSC cis rs500891 0.574 rs10943932 chr6:84155957 A/C cg08257003 chr6:84140564 ME1 0.37 9.02 0.44 1.5e-17 Platelet-derived growth factor BB levels; LUSC cis rs7923609 1.000 rs10761742 chr10:65085048 A/G cg01631684 chr10:65280961 REEP3 -0.42 -6.42 -0.33 4.62e-10 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg22908266 chr2:27273008 AGBL5 -0.46 -7.05 -0.36 1.06e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg24642439 chr20:33292090 TP53INP2 0.51 7.72 0.39 1.4e-13 Height; LUSC cis rs1775715 0.644 rs2799022 chr10:32137198 C/T cg04359828 chr10:32216031 ARHGAP12 0.41 7.07 0.36 9.07e-12 Bipolar disorder with mood-incongruent psychosis; LUSC trans rs3733585 0.699 rs2018643 chr4:9947121 C/T cg26043149 chr18:55253948 FECH 0.44 6.79 0.35 5.22e-11 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs804280 0.542 rs36100659 chr8:11791653 A/T cg08975724 chr8:8085496 FLJ10661 0.5 7.16 0.36 5.12e-12 Myopia (pathological); LUSC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg18131467 chr2:239335373 ASB1 1.04 24.67 0.8 2.93e-77 Multiple system atrophy; LUSC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.33 5.69 0.3 2.78e-8 Menopause (age at onset); LUSC cis rs10754283 0.967 rs1934044 chr1:90107501 C/T cg21401794 chr1:90099060 LRRC8C -0.63 -9.5 -0.46 4.2e-19 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg05340658 chr4:99064831 C4orf37 0.67 11.27 0.52 3.58e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6977660 0.714 rs6977079 chr7:19818207 G/A cg05791153 chr7:19748676 TWISTNB 0.66 7.0 0.36 1.38e-11 Thyroid stimulating hormone; LUSC cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg06550200 chr5:1325588 CLPTM1L -0.67 -11.62 -0.54 1.86e-26 Lung cancer; LUSC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg20307385 chr11:47447363 PSMC3 -0.46 -6.15 -0.32 2.19e-9 Subjective well-being; LUSC trans rs1459104 0.636 rs559362 chr11:55275456 T/G cg03929089 chr4:120376271 NA 0.57 6.07 0.32 3.42e-9 Body mass index; LUSC cis rs2348418 0.864 rs7978086 chr12:28715694 G/T cg13890972 chr12:28721907 NA -0.34 -5.81 -0.3 1.49e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs1728785 0.818 rs1645984 chr16:68628850 T/C cg02972257 chr16:68554789 NA -0.53 -6.48 -0.33 3.3e-10 Ulcerative colitis; LUSC cis rs9814567 0.806 rs4245903 chr3:134317074 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.73 -11.82 -0.54 3.71e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg21724239 chr8:58056113 NA 0.8 8.55 0.42 4.58e-16 Developmental language disorder (linguistic errors); LUSC cis rs2227564 0.700 rs12413039 chr10:75524759 C/G cg17411546 chr10:75410026 SYNPO2L 0.47 5.91 0.31 8.42e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs416603 0.901 rs149597 chr16:11343942 C/G cg00044050 chr16:11439710 C16orf75 -0.66 -11.24 -0.52 4.49e-25 Type 1 diabetes; LUSC trans rs1499614 1.000 rs2659911 chr7:66158420 G/A cg10756647 chr7:56101905 PSPH 0.85 8.47 0.42 7.94e-16 Gout; LUSC cis rs453301 0.522 rs2929455 chr8:9083433 A/T cg15556689 chr8:8085844 FLJ10661 -0.51 -7.63 -0.39 2.46e-13 Joint mobility (Beighton score); LUSC trans rs3942852 0.806 rs4752808 chr11:48141252 G/A cg03929089 chr4:120376271 NA -0.57 -6.85 -0.35 3.59e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs7914558 0.646 rs10883796 chr10:104655315 G/A cg05855489 chr10:104503620 C10orf26 0.42 5.7 0.3 2.64e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs11105298 0.891 rs10777163 chr12:89830720 T/C cg00757033 chr12:89920650 WDR51B 0.54 9.17 0.45 5.05e-18 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg16606324 chr3:10149918 C3orf24 0.62 9.08 0.44 9.8e-18 Alzheimer's disease; LUSC cis rs2835872 0.863 rs702859 chr21:38997701 G/A cg20424643 chr21:39039972 KCNJ6 -0.38 -5.86 -0.31 1.1e-8 Electroencephalographic traits in alcoholism; LUSC cis rs614226 1.000 rs616157 chr12:120925795 T/C cg01236616 chr12:121019343 POP5 -1.24 -18.9 -0.72 1.08e-54 Type 1 diabetes nephropathy; LUSC cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg23260525 chr10:116636907 FAM160B1 0.47 10.15 0.49 2.82e-21 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs11997175 0.545 rs7818001 chr8:33807682 G/T ch.8.33884649F chr8:33765107 NA 0.48 7.23 0.37 3.22e-12 Body mass index; LUSC cis rs6714710 0.603 rs2044459 chr2:98447004 T/C cg26665480 chr2:98280029 ACTR1B 0.61 8.91 0.44 3.25e-17 Posterior cortical atrophy and Alzheimer's disease; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg20530585 chr3:149376036 WWTR1 0.38 6.22 0.32 1.49e-9 Calcium levels; LUSC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.52 0.76 4.61e-65 Prudent dietary pattern; LUSC cis rs12200560 0.505 rs9400167 chr6:97077192 G/T cg06623918 chr6:96969491 KIAA0776 0.5 7.21 0.37 3.75e-12 Coronary heart disease; LUSC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg24531977 chr5:56204891 C5orf35 0.86 13.95 0.61 3.69e-35 Initial pursuit acceleration; LUSC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg11494091 chr17:61959527 GH2 0.4 6.81 0.35 4.47e-11 Height; LUSC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg07211511 chr3:129823064 LOC729375 -1.14 -17.6 -0.69 1.62e-49 Blood pressure (smoking interaction); LUSC cis rs62400317 0.762 rs6909047 chr6:44998915 C/G cg20913747 chr6:44695427 NA -0.44 -6.88 -0.35 3.03e-11 Total body bone mineral density; LUSC cis rs7605827 0.964 rs6748427 chr2:15564799 T/C cg19274914 chr2:15703543 NA 0.47 9.02 0.44 1.47e-17 Educational attainment (years of education); LUSC cis rs61931739 0.635 rs4442626 chr12:33912530 C/T cg06521331 chr12:34319734 NA -0.41 -6.69 -0.34 9.21e-11 Morning vs. evening chronotype; LUSC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg05754148 chr16:3507555 NAT15 0.51 7.54 0.38 4.52e-13 Tuberculosis; LUSC cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg00857998 chr1:205179979 DSTYK 0.59 8.89 0.44 3.85e-17 Mean corpuscular volume;Mean platelet volume; LUSC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg21880101 chr17:80066754 CCDC57 -0.31 -5.87 -0.31 1.03e-8 Life satisfaction; LUSC cis rs2635047 0.905 rs7504798 chr18:44610879 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 7.24 0.37 3.05e-12 Educational attainment; LUSC cis rs2439831 0.867 rs2255440 chr15:43830467 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.79 8.11 0.41 9.54e-15 Lung cancer in ever smokers; LUSC trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg03929089 chr4:120376271 NA 0.68 7.54 0.38 4.38e-13 Acute lymphoblastic leukemia (childhood); LUSC trans rs1493916 0.837 rs4997493 chr18:31407302 C/T cg27147174 chr7:100797783 AP1S1 -0.55 -8.73 -0.43 1.21e-16 Life satisfaction; LUSC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg10523679 chr1:76189770 ACADM 0.91 14.58 0.62 1.3e-37 Blood metabolite levels;Acylcarnitine levels; LUSC trans rs4073416 0.712 rs4899179 chr14:65926748 A/C cg18818563 chr19:9546128 ZNF266 0.4 5.96 0.31 6.54e-9 N-glycan levels; LUSC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.86 11.47 0.53 6.92e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs1577917 1.000 rs12204015 chr6:86598334 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.46 -6.63 -0.34 1.35e-10 Response to antipsychotic treatment; LUSC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg24675658 chr1:53192096 ZYG11B 0.61 9.65 0.47 1.3e-19 Monocyte count; LUSC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg17385448 chr1:15911702 AGMAT 0.37 6.29 0.33 9.81e-10 Systolic blood pressure; LUSC cis rs2463822 1.000 rs2513744 chr11:62077785 C/A cg06239285 chr11:62104954 ASRGL1 0.94 9.3 0.45 1.85e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.62 -13.05 -0.58 9.79e-32 Monocyte percentage of white cells; LUSC cis rs4595586 0.545 rs12823586 chr12:39391677 C/G cg13010199 chr12:38710504 ALG10B 0.41 5.97 0.31 5.93e-9 Morning vs. evening chronotype; LUSC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg13683864 chr3:40499215 RPL14 -1.14 -21.3 -0.76 3.44e-64 Renal cell carcinoma; LUSC cis rs7178572 0.568 rs12906708 chr15:77681444 A/G cg22256960 chr15:77711686 NA -0.5 -7.93 -0.4 3.23e-14 Type 2 diabetes; LUSC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg09699651 chr6:150184138 LRP11 0.37 5.79 0.3 1.61e-8 Lung cancer; LUSC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg16145915 chr7:1198662 ZFAND2A -0.63 -12.38 -0.56 3.04e-29 Longevity;Endometriosis; LUSC cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg13010199 chr12:38710504 ALG10B 0.7 10.75 0.51 2.4e-23 Drug-induced liver injury (flucloxacillin); LUSC cis rs806215 1.000 rs2106186 chr7:127241352 G/C cg25922125 chr7:127225783 GCC1 0.59 7.25 0.37 2.98e-12 Type 2 diabetes; LUSC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg18681998 chr4:17616180 MED28 0.77 13.86 0.6 7.94e-35 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs67072384 1.000 rs2886367 chr11:72455034 C/T cg04827223 chr11:72435913 ARAP1 -0.78 -6.8 -0.35 4.98e-11 Alloimmunization response to red blood cell transfusion in sickle cell anemia; LUSC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg14541582 chr5:601475 NA -0.38 -5.93 -0.31 7.36e-9 Lung disease severity in cystic fibrosis; LUSC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.95 0.36 1.94e-11 Hip circumference adjusted for BMI; LUSC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg14582100 chr15:45693742 SPATA5L1 0.58 10.66 0.5 4.78e-23 Homoarginine levels; LUSC cis rs11971779 0.680 rs6963867 chr7:139059964 T/G cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs11098499 0.866 rs12513310 chr4:120288039 T/A cg24375607 chr4:120327624 NA 0.69 10.6 0.5 7.74e-23 Corneal astigmatism; LUSC cis rs950169 0.840 rs4842853 chr15:84942304 G/T cg17173187 chr15:85201210 NMB 0.37 6.37 0.33 6.23e-10 Schizophrenia; LUSC cis rs10911232 0.507 rs61081633 chr1:182995608 A/G ch.1.3577855R chr1:183094577 LAMC1 0.72 11.05 0.52 2.14e-24 Hypertriglyceridemia; LUSC cis rs2777491 1.000 rs7177641 chr15:41743426 C/T cg18705301 chr15:41695430 NDUFAF1 -0.68 -12.61 -0.57 4.34e-30 Ulcerative colitis; LUSC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg00310523 chr12:86230176 RASSF9 0.52 9.73 0.47 7.31e-20 Major depressive disorder; LUSC trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg15704280 chr7:45808275 SEPT13 -0.63 -7.68 -0.39 1.83e-13 Acute lymphoblastic leukemia (childhood); LUSC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg24531977 chr5:56204891 C5orf35 -0.98 -14.49 -0.62 2.85e-37 Initial pursuit acceleration; LUSC cis rs9325144 0.650 rs6582631 chr12:38744135 T/C cg13010199 chr12:38710504 ALG10B 0.48 7.43 0.38 8.98e-13 Morning vs. evening chronotype; LUSC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg11812906 chr14:75593930 NEK9 0.66 10.87 0.51 9.39e-24 Height; LUSC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg08280861 chr8:58055591 NA 0.54 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); LUSC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg11632617 chr15:75315747 PPCDC -0.51 -6.6 -0.34 1.66e-10 Blood trace element (Zn levels); LUSC cis rs611744 0.503 rs13282220 chr8:109263043 T/C cg18478394 chr8:109455254 TTC35 0.45 6.61 0.34 1.51e-10 Dupuytren's disease; LUSC trans rs11039798 0.588 rs643668 chr11:48413399 C/G cg15704280 chr7:45808275 SEPT13 -0.62 -6.74 -0.35 7.17e-11 Axial length; LUSC cis rs3820068 0.608 rs10927836 chr1:16034368 G/C cg24675056 chr1:15929824 NA 0.41 6.84 0.35 3.9e-11 Systolic blood pressure; LUSC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg05373962 chr22:49881684 NA -0.46 -11.16 -0.52 8.26e-25 Monocyte count;Monocyte percentage of white cells; LUSC cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg26395211 chr5:140044315 WDR55 -0.39 -5.98 -0.31 5.69e-9 Depressive symptoms (multi-trait analysis); LUSC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg01475377 chr6:109611718 NA -0.46 -8.44 -0.42 9.54e-16 Reticulocyte fraction of red cells; LUSC cis rs929354 0.772 rs1182360 chr7:157020550 C/G cg17757837 chr7:157058334 UBE3C 0.81 12.79 0.57 9.22e-31 Body mass index; LUSC trans rs11165623 0.564 rs7555035 chr1:96996026 T/C cg10631902 chr5:14652156 NA -0.41 -6.06 -0.31 3.69e-9 Hip circumference;Waist circumference; LUSC cis rs921968 0.643 rs832799 chr2:219490111 C/A cg02176678 chr2:219576539 TTLL4 0.58 10.61 0.5 7.11e-23 Mean corpuscular hemoglobin concentration; LUSC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg11764359 chr7:65958608 NA 0.5 6.36 0.33 6.75e-10 Aortic root size; LUSC cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.51 5.73 0.3 2.29e-8 Schizophrenia; LUSC cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg08999081 chr20:33150536 PIGU 0.37 6.69 0.34 9.61e-11 Height; LUSC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg00129232 chr17:37814104 STARD3 -0.47 -7.0 -0.36 1.39e-11 Asthma; LUSC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg20933634 chr6:27740509 NA -0.45 -5.93 -0.31 7.47e-9 Parkinson's disease; LUSC cis rs7712401 0.540 rs416763 chr5:122317241 G/A cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs4786125 0.626 rs11077095 chr16:6916451 C/T cg03623568 chr16:6915990 A2BP1 0.48 8.47 0.42 7.96e-16 Heart rate variability traits (SDNN); LUSC cis rs2282032 1.000 rs17799244 chr14:90760040 C/T cg14092571 chr14:90743983 NA 0.47 6.29 0.33 9.72e-10 Longevity; LUSC cis rs140330585 1 rs140330585 chr15:78866445 G/A cg06917634 chr15:78832804 PSMA4 -0.44 -5.97 -0.31 5.94e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg22907277 chr7:1156413 C7orf50 0.72 10.41 0.49 3.75e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7202877 0.706 rs4888393 chr16:75413673 C/T cg04384234 chr16:75411784 CFDP1 -0.66 -9.59 -0.46 2.2e-19 Type 2 diabetes;Type 1 diabetes; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg10135520 chr20:47895337 C20orf199;SNORD12C;ZNFX1 0.38 6.08 0.32 3.34e-9 Triglycerides; LUSC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg22862634 chr11:62369728 EML3;MTA2 0.57 9.21 0.45 3.66e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.42 -5.76 -0.3 1.95e-8 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs12367572 1.000 rs12367572 chr12:45290466 C/T cg04608330 chr12:45269318 NELL2 0.55 8.68 0.43 1.77e-16 Gut microbiome composition (summer); LUSC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg25036284 chr2:26402008 FAM59B 0.76 10.98 0.52 3.69e-24 Gut microbiome composition (summer); LUSC cis rs72781680 0.768 rs56339558 chr2:24125234 G/A cg08917208 chr2:24149416 ATAD2B 0.59 6.83 0.35 3.96e-11 Lymphocyte counts; LUSC cis rs7572644 0.665 rs12478766 chr2:28041200 T/C cg27432699 chr2:27873401 GPN1 0.57 7.28 0.37 2.47e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg19920283 chr7:105172520 RINT1 0.6 6.26 0.32 1.15e-9 Bipolar disorder (body mass index interaction); LUSC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg04369109 chr6:150039330 LATS1 -0.59 -8.61 -0.43 2.98e-16 Lung cancer; LUSC cis rs524023 0.958 rs12802649 chr11:64359627 C/T cg19131476 chr11:64387923 NRXN2 -0.38 -10.2 -0.49 1.96e-21 Urate levels in obese individuals; LUSC cis rs7246657 0.598 rs10405372 chr19:37668775 A/C cg23950597 chr19:37808831 NA -0.57 -5.79 -0.3 1.64e-8 Coronary artery calcification; LUSC cis rs6967385 0.867 rs7808500 chr7:12359042 T/C cg06484146 chr7:12443880 VWDE 0.38 5.72 0.3 2.41e-8 Response to taxane treatment (placlitaxel); LUSC trans rs7819412 0.540 rs2409725 chr8:11041661 T/C cg08975724 chr8:8085496 FLJ10661 -0.43 -5.99 -0.31 5.44e-9 Triglycerides; LUSC cis rs12950390 0.893 rs4794110 chr17:45847230 A/G cg06532163 chr17:45867833 NA 0.34 6.33 0.33 8.02e-10 IgG glycosylation; LUSC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 6.26 0.32 1.21e-9 Platelet count; LUSC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs1372520 0.873 rs2736989 chr4:90776257 T/C cg14346243 chr4:90757452 SNCA -0.41 -5.96 -0.31 6.43e-9 Neuroticism; LUSC cis rs314370 0.951 rs13226502 chr7:100506381 C/T cg18683606 chr7:100471612 SRRT 0.46 6.07 0.32 3.49e-9 Resting heart rate; LUSC cis rs11051970 0.679 rs2733696 chr12:32554635 A/G cg02745156 chr12:32552066 NA 0.37 6.8 0.35 4.69e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7336332 0.598 rs9581850 chr13:28012265 A/G cg22138327 chr13:27999177 GTF3A 0.8 9.82 0.47 3.7e-20 Weight; LUSC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs7474896 0.515 rs2749582 chr10:38275284 A/G cg25427524 chr10:38739819 LOC399744 0.43 5.73 0.3 2.25e-8 Obesity (extreme); LUSC cis rs1832871 0.711 rs9459904 chr6:158700982 C/T cg07165851 chr6:158734300 TULP4 0.5 7.79 0.39 8.52e-14 Height; LUSC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg01238044 chr22:24384105 GSTT1 -0.51 -7.36 -0.37 1.47e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg06064525 chr11:970664 AP2A2 -0.34 -6.75 -0.35 6.61e-11 Alzheimer's disease (late onset); LUSC cis rs9747201 1.000 rs9303020 chr17:80163247 C/T cg17462356 chr17:80056334 FASN -0.43 -5.91 -0.31 8.25e-9 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs8027181 0.839 rs8025333 chr15:73025121 A/G cg25632853 chr15:73088954 NA 0.31 6.4 0.33 5.34e-10 Triglyceride levels; LUSC cis rs7503807 0.935 rs9910745 chr17:78610543 C/T cg09596252 chr17:78655493 RPTOR 0.46 7.82 0.39 7.03e-14 Obesity; LUSC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg21361702 chr7:150065534 REPIN1 0.5 6.9 0.35 2.62e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg10295955 chr4:187884368 NA -1.07 -25.94 -0.82 4.9e-82 Lobe attachment (rater-scored or self-reported); LUSC cis rs17826219 0.568 rs7213925 chr17:29121634 A/G cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Body mass index; LUSC cis rs10782582 0.609 rs111914775 chr1:76319036 C/T cg10523679 chr1:76189770 ACADM -0.48 -6.99 -0.36 1.53e-11 Daytime sleep phenotypes; LUSC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg17366294 chr4:99064904 C4orf37 0.56 9.8 0.47 4.42e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg11062466 chr8:58055876 NA 0.51 6.59 0.34 1.75e-10 Developmental language disorder (linguistic errors); LUSC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg14983838 chr19:29218262 NA 0.6 8.71 0.43 1.39e-16 Methadone dose in opioid dependence; LUSC cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg01528321 chr10:82214614 TSPAN14 0.62 8.98 0.44 2.09e-17 Post bronchodilator FEV1; LUSC cis rs11992162 0.551 rs13268217 chr8:11782609 T/A cg21775007 chr8:11205619 TDH -0.41 -5.79 -0.3 1.62e-8 Monocyte count; LUSC cis rs55665837 0.922 rs12287212 chr11:14449861 C/A cg19336497 chr11:14380999 RRAS2 -0.38 -7.69 -0.39 1.63e-13 Vitamin D levels; LUSC cis rs1568889 1.000 rs78140392 chr11:28203231 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 8.63 0.43 2.62e-16 Bipolar disorder; LUSC cis rs1014246 0.813 rs11197805 chr10:118479677 G/A cg14919929 chr10:118506882 NA 0.45 6.78 0.35 5.34e-11 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs2067615 0.579 rs6539283 chr12:107222989 C/T cg19260189 chr12:106995001 RFX4 0.22 5.69 0.3 2.81e-8 Heart rate; LUSC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.77 -0.35 5.93e-11 Menopause (age at onset); LUSC cis rs10779751 1.000 rs11121704 chr1:11293959 A/G cg08854313 chr1:11322531 MTOR -0.85 -14.96 -0.63 4.49e-39 Body mass index; LUSC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg10523860 chr14:103875565 MARK3 -0.38 -6.16 -0.32 2.15e-9 Body mass index; LUSC cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg11266682 chr4:10021025 SLC2A9 0.58 10.76 0.51 2.21e-23 Bone mineral density; LUSC cis rs722599 0.715 rs61978928 chr14:75321714 T/C cg08847533 chr14:75593920 NEK9 -0.45 -6.45 -0.33 3.88e-10 IgG glycosylation; LUSC trans rs11098499 0.754 rs714899 chr4:120243035 G/A cg25214090 chr10:38739885 LOC399744 0.44 6.58 0.34 1.79e-10 Corneal astigmatism; LUSC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg06640241 chr16:89574553 SPG7 0.91 17.15 0.68 9.99e-48 Multiple myeloma (IgH translocation); LUSC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg11062466 chr8:58055876 NA 0.51 6.5 0.34 2.9e-10 Developmental language disorder (linguistic errors); LUSC trans rs10463316 0.832 rs152087 chr5:150734419 C/T cg04938255 chr1:94312360 MIR760 0.37 6.22 0.32 1.45e-9 Metabolite levels (Pyroglutamine); LUSC cis rs11098499 0.954 rs13151285 chr4:120314741 C/A cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.07e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.92 -0.35 2.31e-11 Monocyte percentage of white cells; LUSC cis rs10465746 0.905 rs34274953 chr1:84415011 G/A cg10977910 chr1:84465055 TTLL7 0.43 6.3 0.33 9.21e-10 Obesity-related traits; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg21881034 chr19:18723557 TMEM59L 0.72 6.17 0.32 1.99e-9 Cognitive performance; LUSC cis rs9513627 0.573 rs12431100 chr13:100184918 C/G cg25919922 chr13:100150906 NA -0.74 -7.84 -0.39 6.07e-14 Obesity-related traits; LUSC cis rs12220238 0.915 rs7922519 chr10:75976573 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.62 7.22 0.37 3.42e-12 Soluble interleukin-2 receptor subunit alpha; LUSC trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg15704280 chr7:45808275 SEPT13 -0.73 -8.36 -0.42 1.74e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs3785574 0.536 rs2854190 chr17:61960219 G/A cg01411255 chr17:61851458 DDX42;CCDC47 1.01 19.95 0.74 7.16e-59 Height; LUSC cis rs57549656 0.799 rs72980725 chr19:2711083 T/C cg06609049 chr19:2785107 THOP1 0.49 6.35 0.33 7.09e-10 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg23029546 chr1:155294555 RUSC1;C1orf104 0.5 6.84 0.35 3.78e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC trans rs62103177 0.673 rs62096717 chr18:77616819 C/T cg05926928 chr17:57297772 GDPD1 1.11 13.96 0.61 3.39e-35 Opioid sensitivity; LUSC cis rs8060686 0.545 rs55897859 chr16:68286748 G/C cg27539214 chr16:67997921 SLC12A4 -0.58 -6.65 -0.34 1.21e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs4953318 0.796 rs10168349 chr2:46360907 G/C cg12428440 chr2:46370979 PRKCE 0.35 6.21 0.32 1.56e-9 Red blood cell count;Hematocrit;Red blood cell traits; LUSC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg22920501 chr2:26401640 FAM59B -0.8 -11.37 -0.53 1.47e-25 Gut microbiome composition (summer); LUSC trans rs62238980 0.614 rs77949114 chr22:32453504 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs662064 0.963 rs10864459 chr1:10563609 C/T cg20482658 chr1:10539492 PEX14 0.32 7.0 0.36 1.38e-11 Asthma; LUSC cis rs7123876 0.546 rs11604837 chr11:72360007 G/A cg03713592 chr11:72463424 ARAP1 0.76 7.88 0.4 4.66e-14 Body mass index; LUSC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg05347473 chr6:146136440 FBXO30 0.56 9.58 0.46 2.29e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs1997103 1.000 rs4628219 chr7:55410449 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg02167203 chr6:41068553 NFYA;LOC221442 -0.39 -5.78 -0.3 1.67e-8 Alzheimer's disease (late onset); LUSC cis rs34779708 0.966 rs12257770 chr10:35517234 A/G cg03585969 chr10:35415529 CREM 0.62 9.27 0.45 2.42e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg13531842 chr10:38383804 ZNF37A -0.43 -6.71 -0.34 8.54e-11 Extrinsic epigenetic age acceleration; LUSC cis rs10911251 0.546 rs2027085 chr1:183108611 G/T ch.1.3577855R chr1:183094577 LAMC1 -0.7 -10.66 -0.5 5.08e-23 Colorectal cancer; LUSC trans rs12317459 0.591 rs11115433 chr12:83200084 T/A cg10237817 chr1:154519846 TDRD10 0.31 6.22 0.32 1.46e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs8072100 0.840 rs9900360 chr17:45491979 C/T cg25173405 chr17:45401733 C17orf57 -0.37 -5.73 -0.3 2.21e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1670533 1.000 rs13119276 chr4:1051574 T/C cg02018176 chr4:1364513 KIAA1530 0.46 6.44 0.33 4.26e-10 Recombination rate (females); LUSC cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg09904177 chr6:26538194 HMGN4 -0.54 -6.43 -0.33 4.46e-10 Intelligence (multi-trait analysis); LUSC cis rs3791556 1.000 rs3791558 chr2:240113255 G/A cg03281426 chr2:240109471 HDAC4 0.51 6.05 0.31 3.97e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs17253792 0.822 rs28831725 chr14:56087569 C/T cg01858014 chr14:56050164 KTN1 -0.83 -6.64 -0.34 1.27e-10 Putamen volume; LUSC cis rs2067615 0.579 rs10778506 chr12:107143260 T/C cg15890332 chr12:107067104 RFX4 0.34 6.27 0.32 1.1e-9 Heart rate; LUSC cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg03146154 chr1:46216737 IPP 0.53 7.89 0.4 4.27e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4356932 1.000 rs4637430 chr4:76962223 G/T cg00809888 chr4:76862425 NAAA 0.36 5.97 0.31 5.91e-9 Blood protein levels; LUSC cis rs4969178 0.620 rs7219625 chr17:76390080 C/T cg05887092 chr17:76393375 PGS1 0.64 12.37 0.56 3.3e-29 HDL cholesterol levels; LUSC cis rs7914558 1.000 rs10883837 chr10:104896486 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.59 0.46 2.18e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg09267113 chr7:98030324 BAIAP2L1 0.39 5.87 0.31 1.07e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.19e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs7917772 0.582 rs10786682 chr10:104318322 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.64 -10.37 -0.49 5.06e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs7241530 0.662 rs11081528 chr18:75902453 G/A cg14642773 chr18:75888474 NA 0.41 6.27 0.32 1.14e-9 Educational attainment (years of education); LUSC cis rs7804356 1.000 rs4722647 chr7:26890446 G/C cg03456212 chr7:26904342 SKAP2 -0.52 -5.95 -0.31 6.64e-9 Type 1 diabetes; LUSC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.49 -7.64 -0.39 2.29e-13 Personality dimensions; LUSC cis rs709400 0.663 rs7152202 chr14:103886757 A/G cg10523860 chr14:103875565 MARK3 -0.4 -6.4 -0.33 5.28e-10 Body mass index; LUSC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg19346786 chr7:2764209 NA -0.48 -8.04 -0.4 1.6e-14 Height; LUSC cis rs7512552 0.839 rs11590787 chr1:150398531 G/A cg15654264 chr1:150340011 RPRD2 0.61 10.04 0.48 6.57e-21 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs1728785 0.901 rs1103286 chr16:68578625 C/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.73 -0.3 2.24e-8 Ulcerative colitis; LUSC cis rs4474465 0.920 rs12222907 chr11:78219726 C/T cg27205649 chr11:78285834 NARS2 0.49 5.69 0.3 2.74e-8 Alzheimer's disease (survival time); LUSC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg13798780 chr7:105162888 PUS7 0.55 6.01 0.31 4.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs2346177 0.542 rs13024414 chr2:46687062 G/A cg02822958 chr2:46747628 ATP6V1E2 0.5 8.77 0.43 9.18e-17 HDL cholesterol; LUSC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg15704280 chr7:45808275 SEPT13 -1.02 -19.39 -0.73 1.25e-56 Height; LUSC cis rs75229567 0.618 rs1599745 chr12:70186029 A/G cg10114359 chr12:70132523 RAB3IP 1.12 10.43 0.5 3.11e-22 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; LUSC cis rs854765 0.594 rs8066560 chr17:17728043 A/G cg04398451 chr17:18023971 MYO15A 0.41 6.26 0.32 1.21e-9 Total body bone mineral density; LUSC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg25456477 chr12:86230367 RASSF9 0.39 6.94 0.36 1.99e-11 Major depressive disorder; LUSC cis rs2251381 0.515 rs2832299 chr21:30749237 G/C cg24692254 chr21:30365293 RNF160 0.68 10.88 0.51 8.46e-24 Selective IgA deficiency; LUSC trans rs453301 0.606 rs7462373 chr8:8899318 G/C cg21775007 chr8:11205619 TDH -0.43 -6.07 -0.32 3.43e-9 Joint mobility (Beighton score); LUSC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg09034736 chr1:150693464 HORMAD1 0.5 7.33 0.37 1.76e-12 Tonsillectomy; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20060523 chr4:142557759 IL15 0.41 5.97 0.31 5.91e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg02782426 chr3:40428986 ENTPD3 0.41 7.7 0.39 1.59e-13 Renal cell carcinoma; LUSC cis rs3771570 1.000 rs55645375 chr2:242269024 A/G cg21155796 chr2:242212141 HDLBP 0.63 6.86 0.35 3.32e-11 Prostate cancer; LUSC cis rs7582180 0.663 rs2309794 chr2:100954270 G/A cg08017756 chr2:100939284 LONRF2 -0.45 -8.35 -0.42 1.82e-15 Intelligence (multi-trait analysis); LUSC cis rs73200209 0.744 rs55643039 chr12:116609355 T/G cg01776926 chr12:116560359 MED13L -0.5 -6.12 -0.32 2.66e-9 Total body bone mineral density; LUSC trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs11105298 0.891 rs10858898 chr12:89922111 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -7.39 -0.37 1.17e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg14530993 chr4:882597 GAK 0.72 7.35 0.37 1.51e-12 Intelligence (multi-trait analysis); LUSC cis rs4660306 1.000 rs7522705 chr1:45992300 C/G cg05343316 chr1:45956843 TESK2 -0.41 -5.83 -0.3 1.34e-8 Homocysteine levels; LUSC cis rs72781680 0.950 rs72796343 chr2:24147631 G/A cg20701182 chr2:24300061 SF3B14 0.77 7.73 0.39 1.25e-13 Lymphocyte counts; LUSC trans rs5003154 0.905 rs13273982 chr8:82001360 C/G cg02238051 chr16:1777708 MAPK8IP3 -0.41 -6.32 -0.33 8.31e-10 Bladder cancer; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21899138 chr3:52720056 GNL3;PBRM1 0.38 6.14 0.32 2.31e-9 Asthma; LUSC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg21951975 chr1:209979733 IRF6 0.55 6.97 0.36 1.74e-11 Cleft lip with or without cleft palate; LUSC trans rs10435719 0.638 rs67146188 chr8:11782433 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.41 -0.33 5.05e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 13.53 0.6 1.44e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9467773 1.000 rs2224380 chr6:26553943 G/A cg09904177 chr6:26538194 HMGN4 0.75 14.04 0.61 1.66e-35 Intelligence (multi-trait analysis); LUSC cis rs7809950 0.635 rs62483629 chr7:106866178 T/C cg23024343 chr7:107201750 COG5 -0.66 -9.34 -0.46 1.35e-18 Coronary artery disease; LUSC cis rs4919694 0.908 rs11191523 chr10:104792400 A/G cg04362960 chr10:104952993 NT5C2 1.17 13.66 0.6 4.72e-34 Arsenic metabolism; LUSC cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg03517284 chr6:25882590 NA -0.52 -9.66 -0.47 1.25e-19 Blood metabolite levels; LUSC cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs2795502 0.882 rs2744091 chr10:43339441 A/G cg20628663 chr10:43360327 NA -0.76 -11.24 -0.52 4.48e-25 Blood protein levels; LUSC cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg21643547 chr1:205240462 TMCC2 -0.53 -10.17 -0.49 2.36e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg03517284 chr6:25882590 NA 0.47 7.8 0.39 7.86e-14 Intelligence (multi-trait analysis); LUSC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg17143192 chr8:8559678 CLDN23 0.59 8.58 0.42 3.71e-16 Obesity-related traits; LUSC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg15448220 chr1:150897856 SETDB1 0.44 6.43 0.33 4.41e-10 Melanoma; LUSC cis rs472402 0.560 rs2288444 chr5:6619923 A/G cg10789808 chr5:6633262 NSUN2;SRD5A1 -0.4 -5.91 -0.31 8.5e-9 Response to amphetamines; LUSC cis rs1775715 0.870 rs10827003 chr10:32266216 A/G cg04359828 chr10:32216031 ARHGAP12 0.37 6.09 0.32 3.19e-9 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg02380750 chr20:61661411 NA 0.34 5.93 0.31 7.57e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs897984 0.644 rs73524556 chr16:30823162 G/A cg00531865 chr16:30841666 NA -0.34 -6.11 -0.32 2.77e-9 Dementia with Lewy bodies; LUSC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg15744005 chr10:104629667 AS3MT -0.29 -6.26 -0.32 1.2e-9 Reticulocyte count; LUSC cis rs981844 1.000 rs62325085 chr4:154663283 A/G cg14289246 chr4:154710475 SFRP2 0.5 6.44 0.33 4.05e-10 Response to statins (LDL cholesterol change); LUSC cis rs7809950 1.000 rs2520264 chr7:107179344 T/C cg23024343 chr7:107201750 COG5 -0.55 -8.72 -0.43 1.32e-16 Coronary artery disease; LUSC cis rs9300255 0.506 rs11057251 chr12:123791227 A/G cg00376283 chr12:123451042 ABCB9 -0.7 -10.77 -0.51 2.12e-23 Neutrophil percentage of white cells; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg14642671 chr17:48450604 EME1;MRPL27 0.76 6.23 0.32 1.37e-9 Body mass index; LUSC cis rs9807989 0.765 rs6751967 chr2:102967413 T/C cg09003973 chr2:102972529 NA 0.45 6.19 0.32 1.8e-9 Asthma; LUSC cis rs782590 0.683 rs782633 chr2:55898203 A/G cg18811423 chr2:55921094 PNPT1 0.89 15.83 0.65 1.63e-42 Metabolic syndrome; LUSC cis rs11122272 0.735 rs2244994 chr1:231537127 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.99 -0.48 1.01e-20 Hemoglobin concentration; LUSC cis rs61935443 0.666 rs11107781 chr12:95301086 T/A cg21533806 chr12:95267307 NA 0.49 5.7 0.3 2.63e-8 Schizophrenia; LUSC cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg23093090 chr10:104574429 C10orf26 -0.45 -8.54 -0.42 4.97e-16 Immature fraction of reticulocytes;Schizophrenia; LUSC cis rs9814567 0.502 rs12634127 chr3:134256159 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -8.36 -0.42 1.71e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06869160 chr12:89919815 GALNT4;WDR51B -0.4 -6.02 -0.31 4.66e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10992471 0.603 rs10992349 chr9:95233887 T/C cg14631576 chr9:95140430 CENPP -0.34 -6.17 -0.32 1.97e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg18252515 chr7:66147081 NA -1.24 -13.61 -0.6 7.06e-34 Diabetic kidney disease; LUSC cis rs12530845 1.000 rs12540688 chr7:135329690 T/C cg23117316 chr7:135346802 PL-5283 -0.57 -9.85 -0.47 2.84e-20 Red blood cell traits; LUSC cis rs865483 0.895 rs2107104 chr17:35835031 G/A cg06716730 chr17:35851459 DUSP14 0.27 6.12 0.32 2.59e-9 Monocyte count; LUSC cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.38 -6.27 -0.32 1.12e-9 Intelligence (multi-trait analysis); LUSC cis rs632111 0.519 rs281380 chr19:49214470 A/G cg21064579 chr19:49206444 FUT2 -0.33 -5.97 -0.31 6.2e-9 Serum lipase activity; LUSC cis rs6681460 0.649 rs967322 chr1:67003446 C/T cg02459107 chr1:67143332 SGIP1 0.37 6.18 0.32 1.92e-9 Presence of antiphospholipid antibodies; LUSC cis rs2730245 0.527 rs924910 chr7:158672272 C/T cg11984989 chr7:158649758 WDR60 1.12 13.33 0.59 8.35e-33 Height; LUSC cis rs7918232 0.698 rs6482586 chr10:27297829 A/C cg14442939 chr10:27389572 ANKRD26 0.49 5.85 0.3 1.17e-8 Breast cancer; LUSC cis rs7106204 0.609 rs34237482 chr11:24295932 G/A ch.11.24196551F chr11:24239977 NA 0.69 5.68 0.3 2.86e-8 Response to Homoharringtonine (cytotoxicity); LUSC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -7.11 -0.36 6.97e-12 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.75 -0.35 6.5500000000000006e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs9443645 0.611 rs10943616 chr6:79823541 G/A cg05283184 chr6:79620031 NA -0.43 -8.08 -0.4 1.19e-14 Intelligence (multi-trait analysis); LUSC cis rs55665837 1.000 rs10832268 chr11:14465068 C/A cg05501817 chr11:14380813 RRAS2 -0.4 -6.54 -0.34 2.3e-10 Vitamin D levels; LUSC cis rs17270561 0.609 rs9348695 chr6:25763010 A/T cg17691542 chr6:26056736 HIST1H1C 0.53 7.38 0.37 1.26e-12 Iron status biomarkers; LUSC cis rs9372498 0.536 rs72952733 chr6:118834452 A/G cg18833306 chr6:118973337 C6orf204 -0.45 -5.69 -0.3 2.81e-8 Diastolic blood pressure; LUSC cis rs4969178 0.965 rs8075131 chr17:76394595 T/G cg20026190 chr17:76395443 PGS1 0.45 8.17 0.41 6.52e-15 HDL cholesterol levels; LUSC cis rs9534288 0.742 rs7337140 chr13:46641481 C/T cg15192986 chr13:46630673 CPB2 0.73 11.23 0.52 4.69e-25 Blood protein levels; LUSC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg11062466 chr8:58055876 NA 0.64 8.44 0.42 1.01e-15 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg13319975 chr6:146136371 FBXO30 -0.47 -6.99 -0.36 1.53e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs4595586 0.545 rs4411311 chr12:39363612 C/G cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.38e-9 Morning vs. evening chronotype; LUSC cis rs1348850 0.645 rs4893963 chr2:178430747 A/G cg23306229 chr2:178417860 TTC30B -0.53 -6.0 -0.31 5.23e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs1788820 0.917 rs1788825 chr18:21109250 T/C cg14672496 chr18:21087552 C18orf8 0.43 6.8 0.35 4.81e-11 Body mass index; LUSC cis rs6964587 1.000 rs12533199 chr7:91757393 C/T cg22117172 chr7:91764530 CYP51A1 0.32 5.74 0.3 2.17e-8 Breast cancer; LUSC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs2710642 0.821 rs2710639 chr2:63138963 C/T cg17519650 chr2:63277830 OTX1 0.44 6.08 0.32 3.26e-9 LDL cholesterol levels;LDL cholesterol; LUSC cis rs11105298 0.891 rs10858906 chr12:89934474 C/T cg00757033 chr12:89920650 WDR51B 0.61 10.77 0.51 2.12e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs9911578 0.757 rs8081906 chr17:56631907 A/T cg05425664 chr17:57184151 TRIM37 0.56 7.92 0.4 3.48e-14 Intelligence (multi-trait analysis); LUSC cis rs13256369 0.802 rs2280560 chr8:8560602 C/T cg18904891 chr8:8559673 CLDN23 0.6 7.89 0.4 4.36e-14 Obesity-related traits; LUSC cis rs950776 0.518 rs12910289 chr15:78822065 T/G cg06917634 chr15:78832804 PSMA4 0.83 14.9 0.63 7.48e-39 Sudden cardiac arrest; LUSC cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg04727924 chr7:799746 HEATR2 -0.54 -6.71 -0.34 8.46e-11 Cerebrospinal P-tau181p levels; LUSC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg16447950 chr5:562315 NA -0.55 -6.78 -0.35 5.34e-11 Obesity-related traits; LUSC cis rs2204008 0.744 rs11181337 chr12:38322083 C/A cg26384229 chr12:38710491 ALG10B 0.83 13.63 0.6 5.96e-34 Bladder cancer; LUSC cis rs73198271 0.603 rs570364 chr8:8593638 G/T cg01851573 chr8:8652454 MFHAS1 0.4 6.22 0.32 1.52e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs1160297 0.609 rs78310136 chr2:53093171 G/A cg07782112 chr2:53107842 NA 0.44 7.18 0.37 4.58e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs4076764 0.846 rs7525724 chr1:163426372 G/A cg24596788 chr1:163392923 NA -0.4 -6.91 -0.35 2.53e-11 Motion sickness; LUSC cis rs5769765 0.908 rs2319464 chr22:50265777 A/G cg26441486 chr22:50317300 CRELD2 -0.55 -8.23 -0.41 4.11e-15 Schizophrenia; LUSC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -7.0 -0.36 1.4e-11 Intelligence (multi-trait analysis); LUSC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg14983838 chr19:29218262 NA 0.66 9.29 0.45 1.98e-18 Methadone dose in opioid dependence; LUSC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg13319975 chr6:146136371 FBXO30 0.72 11.07 0.52 1.73e-24 Lobe attachment (rater-scored or self-reported); LUSC cis rs12681288 0.823 rs2701906 chr8:1003316 T/C cg15309053 chr8:964076 NA 0.34 6.98 0.36 1.62e-11 Schizophrenia; LUSC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg24675658 chr1:53192096 ZYG11B -0.67 -10.66 -0.5 4.97e-23 Monocyte count; LUSC cis rs9814567 0.752 rs4955547 chr3:134334975 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -12.49 -0.56 1.24e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14442939 chr10:27389572 ANKRD26 -0.91 -7.98 -0.4 2.36e-14 Breast cancer; LUSC cis rs3739821 0.841 rs943392 chr9:130725441 A/G cg21181453 chr9:130700954 DPM2 -0.31 -6.3 -0.33 9.15e-10 Glaucoma (primary angle closure); LUSC cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg22508957 chr16:3507546 NAT15 -0.66 -10.85 -0.51 1.04e-23 Tuberculosis; LUSC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.32 -0.33 8.19e-10 Lung cancer; LUSC cis rs6977660 1.000 rs10260527 chr7:19801930 G/A cg07541023 chr7:19748670 TWISTNB 0.56 6.36 0.33 6.55e-10 Thyroid stimulating hormone; LUSC cis rs12618769 0.652 rs7588254 chr2:99217785 G/T cg10123293 chr2:99228465 UNC50 0.43 6.93 0.35 2.19e-11 Bipolar disorder; LUSC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.69 -10.41 -0.49 3.64e-22 Lymphocyte counts; LUSC trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg20587970 chr11:113659929 NA -1.28 -17.59 -0.69 1.83e-49 Hip circumference adjusted for BMI; LUSC cis rs3774749 0.565 rs2518796 chr3:50207075 A/G cg14019146 chr3:50243930 SLC38A3 -0.44 -10.42 -0.5 3.44e-22 Intelligence (multi-trait analysis); LUSC cis rs11098499 0.754 rs10213267 chr4:120239074 A/G cg24375607 chr4:120327624 NA 0.76 12.22 0.56 1.2e-28 Corneal astigmatism; LUSC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg13453750 chr1:205783389 SLC41A1 -0.33 -6.41 -0.33 5.09e-10 Menarche (age at onset); LUSC cis rs6845621 0.835 rs9995472 chr4:18935997 A/G cg12196642 chr4:18937545 NA -0.36 -6.76 -0.35 6.14e-11 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs9905704 0.624 rs11652761 chr17:56986095 C/T cg12560992 chr17:57184187 TRIM37 0.59 9.44 0.46 6.84e-19 Testicular germ cell tumor; LUSC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg11663144 chr21:46675770 NA -0.4 -6.81 -0.35 4.49e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg26314531 chr2:26401878 FAM59B -0.46 -5.89 -0.31 9.19e-9 Gut microbiome composition (summer); LUSC cis rs4363385 0.719 rs6587714 chr1:152933023 T/C cg07796016 chr1:152779584 LCE1C -0.47 -6.64 -0.34 1.26e-10 Inflammatory skin disease; LUSC cis rs9300255 0.679 rs10772998 chr12:123721177 T/G cg13010344 chr12:123464640 ARL6IP4 -0.43 -5.88 -0.31 9.74e-9 Neutrophil percentage of white cells; LUSC trans rs7818345 0.649 rs13250181 chr8:19328766 G/A cg07611933 chr16:2773245 NA -0.23 -6.07 -0.32 3.49e-9 Language performance in older adults (adjusted for episodic memory); LUSC cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg13319975 chr6:146136371 FBXO30 0.49 7.34 0.37 1.69e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs911119 0.909 rs3761279 chr20:23620075 C/G cg16589663 chr20:23618590 CST3 0.6 7.08 0.36 8.36e-12 Chronic kidney disease; LUSC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg17971929 chr21:40555470 PSMG1 -0.5 -7.35 -0.37 1.51e-12 Menarche (age at onset); LUSC cis rs11098499 0.754 rs12510269 chr4:120241646 A/G cg24375607 chr4:120327624 NA 0.77 12.25 0.56 9.43e-29 Corneal astigmatism; LUSC cis rs6580649 0.883 rs7967762 chr12:48420214 C/T cg24011408 chr12:48396354 COL2A1 -0.49 -6.57 -0.34 1.89e-10 Lung cancer; LUSC cis rs1568889 0.887 rs2062269 chr11:28116537 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.73 12.89 0.58 3.95e-31 Bipolar disorder; LUSC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg18230493 chr5:56204884 C5orf35 0.76 12.7 0.57 1.93e-30 Initial pursuit acceleration; LUSC cis rs11122272 0.735 rs2474625 chr1:231519331 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs1577917 0.883 rs6454505 chr6:86592362 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -6.0 -0.31 5.22e-9 Response to antipsychotic treatment; LUSC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg22963979 chr7:1858916 MAD1L1 -0.43 -6.58 -0.34 1.77e-10 Schizophrenia; LUSC cis rs7210086 0.808 rs3935122 chr17:70641315 C/T cg04206342 chr17:70636940 NA -0.39 -6.42 -0.33 4.57e-10 Ulcerative colitis; LUSC trans rs61931739 0.534 rs4539411 chr12:34014807 T/C cg13010199 chr12:38710504 ALG10B 0.53 8.0 0.4 2.12e-14 Morning vs. evening chronotype; LUSC cis rs11190604 1.000 rs10883502 chr10:102238343 T/G cg16342193 chr10:102329863 NA -0.35 -6.32 -0.33 8.52e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs2348418 0.966 rs7315631 chr12:28698244 A/G cg13890972 chr12:28721907 NA -0.34 -5.75 -0.3 2.06e-8 Lung function (FVC);Lung function (FEV1); LUSC cis rs3806843 0.548 rs246056 chr5:140325600 G/A cg19875535 chr5:140030758 IK 0.37 5.65 0.3 3.38e-8 Depressive symptoms (multi-trait analysis); LUSC trans rs2797160 1.000 rs1935774 chr6:125996661 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 7.05 0.36 1.06e-11 Endometrial cancer; LUSC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.33 0.33 7.9e-10 Mean platelet volume; LUSC cis rs6577655 0.517 rs4909295 chr8:135588042 G/A cg17885191 chr8:135476712 NA 0.59 7.75 0.39 1.1e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg27170947 chr2:26402098 FAM59B 0.71 10.85 0.51 1.04e-23 Gut microbiome composition (summer); LUSC trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg03929089 chr4:120376271 NA 0.68 7.43 0.38 9.31e-13 Axial length; LUSC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg09267113 chr7:98030324 BAIAP2L1 0.39 5.89 0.31 9.58e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg01874867 chr7:94954059 PON1 -0.49 -9.64 -0.47 1.48e-19 Paraoxonase activity; LUSC cis rs11252926 0.931 rs4881399 chr10:567325 A/G cg16386425 chr10:429943 DIP2C -0.4 -6.08 -0.32 3.29e-9 Psychosis in Alzheimer's disease; LUSC cis rs3540 0.512 rs3930162 chr15:91075129 C/T cg10434728 chr15:90938212 IQGAP1 -0.44 -9.06 -0.44 1.15e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg23711669 chr6:146136114 FBXO30 0.76 13.55 0.6 1.27e-33 Lobe attachment (rater-scored or self-reported); LUSC trans rs2894969 0.664 rs11252703 chr10:4795125 A/T cg01633858 chr22:43547540 TSPO 0.4 6.04 0.31 4.14e-9 Major depressive disorder; LUSC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg02891314 chr5:179741120 GFPT2 0.61 10.06 0.48 5.62e-21 Height; LUSC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg10755058 chr3:40428713 ENTPD3 0.35 5.85 0.3 1.17e-8 Renal cell carcinoma; LUSC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg24531977 chr5:56204891 C5orf35 -0.69 -10.2 -0.49 1.92e-21 Coronary artery disease; LUSC cis rs72781680 0.699 rs72796125 chr2:23919169 C/T cg08917208 chr2:24149416 ATAD2B 1.0 10.18 0.49 2.21e-21 Lymphocyte counts; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg18578119 chr4:1236638 CTBP1 -0.69 -6.73 -0.35 7.52e-11 Cognitive performance; LUSC cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg26384229 chr12:38710491 ALG10B 0.92 17.56 0.69 2.35e-49 Heart rate; LUSC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg13531842 chr10:38383804 ZNF37A -0.47 -7.39 -0.37 1.2e-12 Extrinsic epigenetic age acceleration; LUSC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg11764359 chr7:65958608 NA -0.7 -10.66 -0.5 5e-23 Aortic root size; LUSC cis rs17401966 0.898 rs11582123 chr1:10303942 A/T cg19773385 chr1:10388646 KIF1B -0.6 -10.29 -0.49 9.18e-22 Hepatocellular carcinoma; LUSC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg24503407 chr1:205819492 PM20D1 -0.9 -16.82 -0.68 1.99e-46 Menarche (age at onset); LUSC trans rs7937682 0.632 rs10891297 chr11:111770150 C/T cg18187862 chr3:45730750 SACM1L -0.53 -6.42 -0.33 4.73e-10 Primary sclerosing cholangitis; LUSC cis rs2637266 0.935 rs2579775 chr10:78401677 G/A cg18941641 chr10:78392320 NA 0.42 7.67 0.39 1.94e-13 Pulmonary function; LUSC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg13939156 chr17:80058883 NA 0.33 6.47 0.33 3.45e-10 Life satisfaction; LUSC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg04775059 chr7:64541387 NA -0.45 -5.67 -0.3 3.13e-8 Aortic root size; LUSC cis rs1577917 0.958 rs12213431 chr6:86500956 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.43 -6.36 -0.33 6.69e-10 Response to antipsychotic treatment; LUSC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg01065977 chr19:18549689 ISYNA1 -0.24 -6.07 -0.32 3.45e-9 Breast cancer; LUSC cis rs9549367 0.789 rs9549365 chr13:113907391 C/T cg00898013 chr13:113819073 PROZ 0.53 7.91 0.4 3.72e-14 Platelet distribution width; LUSC trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg15704280 chr7:45808275 SEPT13 -0.81 -11.29 -0.53 2.88e-25 Coronary artery disease; LUSC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.22e-8 Aortic root size; LUSC cis rs925550 0.932 rs6844999 chr4:123581235 T/G cg10495464 chr4:123653540 BBS12;LOC729338 -0.57 -5.69 -0.3 2.71e-8 Primary biliary cholangitis; LUSC cis rs41271473 0.526 rs10916344 chr1:228737489 C/T cg10167378 chr1:228756711 NA 0.76 10.12 0.48 3.68e-21 Chronic lymphocytic leukemia; LUSC cis rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05901451 chr6:126070800 HEY2 -0.58 -8.78 -0.43 8.6e-17 Endometrial cancer; LUSC cis rs6430585 0.697 rs1050115 chr2:136511817 A/G cg07169764 chr2:136633963 MCM6 1.18 17.35 0.69 1.61e-48 Corneal structure; LUSC cis rs34115320 1 rs34115320 chr7:148783936 CT/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 7.25 0.37 3.01e-12 Sum basophil neutrophil counts;Neutrophil count; LUSC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg20307385 chr11:47447363 PSMC3 0.45 5.82 0.3 1.37e-8 Subjective well-being; LUSC cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg04117972 chr1:227635322 NA 0.62 7.06 0.36 9.84e-12 Major depressive disorder; LUSC trans rs7824557 0.564 rs55758514 chr8:11230259 A/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.6 -0.34 1.59e-10 Retinal vascular caliber; LUSC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg24060327 chr5:131705240 SLC22A5 -0.38 -6.22 -0.32 1.49e-9 Blood metabolite levels; LUSC cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg12863693 chr15:85201151 NMB 0.33 6.28 0.32 1.05e-9 Schizophrenia; LUSC cis rs1707322 0.613 rs1473840 chr1:46601197 A/G cg06784218 chr1:46089804 CCDC17 -0.39 -7.14 -0.36 5.75e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg11663144 chr21:46675770 NA -0.41 -7.14 -0.36 5.77e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg14844989 chr11:31128820 NA -0.39 -6.02 -0.31 4.6e-9 Red blood cell count; LUSC cis rs9905704 0.671 rs2531737 chr17:56554357 A/G cg19466818 chr17:56409534 MIR142 0.35 6.5 0.34 2.94e-10 Testicular germ cell tumor; LUSC cis rs35123781 1.000 rs682164 chr5:139058589 A/G cg10513866 chr5:139070639 NA 0.45 9.05 0.44 1.21e-17 Schizophrenia; LUSC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg03806693 chr22:41940476 POLR3H 0.99 13.92 0.61 4.89e-35 Vitiligo; LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg02592596 chr15:30919014 ARHGAP11B 0.35 6.14 0.32 2.28e-9 Tuberculosis; LUSC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg06221963 chr1:154839813 KCNN3 -0.64 -14.98 -0.63 3.73e-39 Prostate cancer; LUSC cis rs7191439 0.858 rs2290902 chr16:88782676 A/G cg27087555 chr16:88793112 FAM38A -1.47 -14.65 -0.63 7.21e-38 Plateletcrit; LUSC cis rs4566357 1.000 rs6436649 chr2:227923952 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -5.9 -0.31 8.79e-9 Coronary artery disease; LUSC cis rs12579753 0.797 rs1922561 chr12:82152640 C/A cg21231944 chr12:82153410 PPFIA2 -0.4 -6.2 -0.32 1.63e-9 Resting heart rate; LUSC cis rs7241530 0.662 rs12961616 chr18:75908142 T/G cg14642773 chr18:75888474 NA 0.39 5.74 0.3 2.17e-8 Educational attainment (years of education); LUSC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg05347473 chr6:146136440 FBXO30 0.47 7.61 0.38 2.88e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs11971779 0.680 rs11760420 chr7:139114768 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg08280861 chr8:58055591 NA 0.55 6.46 0.33 3.69e-10 Developmental language disorder (linguistic errors); LUSC cis rs72700829 0.593 rs77209899 chr1:150992019 G/A cg11822372 chr1:151115635 SEMA6C -0.74 -6.77 -0.35 5.98e-11 Schizophrenia; LUSC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg01411255 chr17:61851458 DDX42;CCDC47 1.07 22.79 0.78 5.28e-70 Height; LUSC cis rs7089973 0.604 rs11196932 chr10:116584386 C/T cg03647239 chr10:116582469 FAM160B1 0.45 7.21 0.37 3.81e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg25036284 chr2:26402008 FAM59B -0.67 -9.43 -0.46 6.88e-19 Gut microbiome composition (summer); LUSC cis rs9815354 0.812 rs73069292 chr3:41973963 T/C cg03022575 chr3:42003672 ULK4 0.85 8.85 0.44 5.2e-17 Pulse pressure;Diastolic blood pressure; LUSC cis rs344364 0.602 rs2437745 chr16:1908431 G/C cg00564555 chr16:1970112 NA 0.38 6.47 0.33 3.47e-10 Glomerular filtration rate in chronic kidney disease; LUSC cis rs8017423 0.605 rs3742673 chr14:90735707 C/T cg14092571 chr14:90743983 NA -0.34 -5.66 -0.3 3.19e-8 Mortality in heart failure; LUSC cis rs752010 0.841 rs17363834 chr1:42076607 C/T cg06885757 chr1:42089581 HIVEP3 0.41 8.4 0.42 1.26e-15 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.52 8.03 0.4 1.66e-14 Prudent dietary pattern; LUSC cis rs12519773 0.905 rs13177386 chr5:92443605 A/C cg18783429 chr5:92414398 NA 0.28 5.95 0.31 6.86e-9 Migraine; LUSC cis rs68170813 0.559 rs7783181 chr7:106977613 A/G cg02696742 chr7:106810147 HBP1 -0.63 -9.52 -0.46 3.74e-19 Coronary artery disease; LUSC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg02782426 chr3:40428986 ENTPD3 0.37 7.09 0.36 8.04e-12 Renal cell carcinoma; LUSC trans rs9944715 0.954 rs7231820 chr18:43823431 G/A cg01718231 chr17:29326311 RNF135 -0.5 -7.07 -0.36 9.28e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg23711669 chr6:146136114 FBXO30 0.88 16.1 0.66 1.48e-43 Lobe attachment (rater-scored or self-reported); LUSC trans rs7824557 0.603 rs2249804 chr8:11215617 C/G cg06636001 chr8:8085503 FLJ10661 0.55 8.11 0.41 1e-14 Retinal vascular caliber; LUSC cis rs6424115 0.830 rs3003335 chr1:24200052 A/G cg10978503 chr1:24200527 CNR2 0.54 13.24 0.59 1.85e-32 Immature fraction of reticulocytes; LUSC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg19678392 chr7:94953810 PON1 -0.36 -5.65 -0.3 3.47e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs12594515 1.000 rs8032835 chr15:45997897 C/G cg06207120 chr15:45996521 NA 0.39 6.04 0.31 4.12e-9 Waist circumference;Weight; LUSC cis rs977987 0.586 rs12920883 chr16:75432681 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -6.9 -0.35 2.55e-11 Dupuytren's disease; LUSC cis rs10779751 0.762 rs6671083 chr1:11325910 A/G cg08854313 chr1:11322531 MTOR -0.69 -11.9 -0.55 1.85e-27 Body mass index; LUSC cis rs7520050 0.807 rs4468203 chr1:46113272 T/C cg24296786 chr1:45957014 TESK2 -0.41 -5.81 -0.3 1.47e-8 Red blood cell count;Reticulocyte count; LUSC trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg20587970 chr11:113659929 NA -1.03 -13.81 -0.6 1.22e-34 Hip circumference adjusted for BMI; LUSC cis rs611744 0.538 rs59930666 chr8:109262296 T/C cg18478394 chr8:109455254 TTC35 0.46 7.12 0.36 6.76e-12 Dupuytren's disease; LUSC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg23711669 chr6:146136114 FBXO30 0.74 11.45 0.53 7.84e-26 Lobe attachment (rater-scored or self-reported); LUSC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg07936489 chr17:37558343 FBXL20 0.73 10.27 0.49 1.12e-21 Glomerular filtration rate (creatinine); LUSC cis rs9297145 0.724 rs6958790 chr7:98774738 C/T cg05967295 chr7:98741636 SMURF1 -0.96 -14.15 -0.61 5.98e-36 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg08975724 chr8:8085496 FLJ10661 -0.39 -5.65 -0.3 3.44e-8 Joint mobility (Beighton score); LUSC cis rs9905704 0.647 rs11652713 chr17:57079742 C/T cg05425664 chr17:57184151 TRIM37 -0.48 -7.14 -0.36 5.87e-12 Testicular germ cell tumor; LUSC cis rs478304 0.651 rs948494 chr11:65552118 G/A cg17480646 chr11:65405466 SIPA1 -0.46 -5.94 -0.31 7.01e-9 Acne (severe); LUSC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13126279 chr21:47581558 C21orf56 -0.53 -8.1 -0.41 1.03e-14 Testicular germ cell tumor; LUSC cis rs7089973 0.604 rs17663670 chr10:116596269 A/C cg03647239 chr10:116582469 FAM160B1 -0.44 -7.08 -0.36 8.61e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7937682 0.883 rs1613778 chr11:111456105 G/C cg11344533 chr11:111475393 SIK2 -0.46 -6.35 -0.33 6.87e-10 Primary sclerosing cholangitis; LUSC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.94 0.61 4.03e-35 Platelet count; LUSC trans rs9467711 0.606 rs13190739 chr6:26587373 G/T cg06606381 chr12:133084897 FBRSL1 -0.81 -7.09 -0.36 8.24e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs61931739 0.534 rs10844728 chr12:34020109 G/C cg06521331 chr12:34319734 NA -0.47 -7.58 -0.38 3.42e-13 Morning vs. evening chronotype; LUSC cis rs10419226 0.541 rs11883401 chr19:18791768 C/G cg22001208 chr19:18782374 NA -0.38 -6.45 -0.33 3.85e-10 Barrett's esophagus;Esophageal adenocarcinoma;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg06484146 chr7:12443880 VWDE -0.68 -7.23 -0.37 3.41e-12 Coronary artery disease; LUSC cis rs662735 0.515 rs686901 chr11:30854334 C/G cg06552810 chr11:31128660 NA 0.33 5.84 0.3 1.27e-8 Hemoglobin concentration;Hematocrit; LUSC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg14552801 chr7:65878734 NA -0.45 -6.34 -0.33 7.34e-10 Aortic root size; LUSC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg24531977 chr5:56204891 C5orf35 0.86 13.85 0.6 8.6e-35 Initial pursuit acceleration; LUSC cis rs10751667 0.961 rs6597953 chr11:991099 G/A cg01483505 chr11:975446 AP2A2 0.41 5.7 0.3 2.58e-8 Alzheimer's disease (late onset); LUSC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg26441486 chr22:50317300 CRELD2 -0.47 -7.18 -0.37 4.69e-12 Schizophrenia; LUSC cis rs11098499 0.644 rs10009566 chr4:120558608 A/G cg24375607 chr4:120327624 NA 0.7 11.2 0.52 6.37e-25 Corneal astigmatism; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg20152424 chr11:576455 PHRF1;LOC143666 -0.41 -5.99 -0.31 5.55e-9 Hepatitis; LUSC cis rs11630290 0.592 rs4777332 chr15:64158112 A/G cg12036633 chr15:63758958 NA 0.53 6.73 0.35 7.35e-11 Iris characteristics; LUSC cis rs3892630 0.878 rs66788054 chr19:33190146 G/T cg22980127 chr19:33182716 NUDT19 0.94 12.81 0.57 7.79e-31 Red blood cell traits; LUSC trans rs35110281 0.659 rs73367822 chr21:45024252 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.58 9.78 0.47 4.84e-20 Mean corpuscular volume; LUSC cis rs6701037 1.000 rs7512413 chr1:175124789 C/T cg17845761 chr1:175162550 KIAA0040 -0.31 -6.0 -0.31 5.07e-9 Alcohol dependence; LUSC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg04234412 chr22:24373322 LOC391322 -0.86 -14.09 -0.61 1.09e-35 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs2172802 0.659 rs4484334 chr4:62499841 C/T cg04118610 chr4:62707027 LPHN3 0.45 6.17 0.32 1.94e-9 Partial epilepsies; LUSC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg21138405 chr5:131827807 IRF1 -0.53 -10.38 -0.49 4.57e-22 Asthma (sex interaction); LUSC cis rs11229555 0.645 rs10896774 chr11:58175837 T/G cg15696309 chr11:58395628 NA -0.63 -7.83 -0.39 6.48e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg11965913 chr1:205819406 PM20D1 0.52 8.8 0.43 7.35e-17 Menarche (age at onset); LUSC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.92 0.48 1.68e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg07343612 chr16:622815 PIGQ -0.72 -12.16 -0.55 2e-28 Height; LUSC cis rs9361491 0.510 rs1507151 chr6:79483246 T/C cg05283184 chr6:79620031 NA -0.45 -8.15 -0.41 7.42e-15 Intelligence (multi-trait analysis); LUSC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg19592336 chr6:28129416 ZNF389 0.53 7.05 0.36 1.02e-11 Parkinson's disease; LUSC cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg12165864 chr7:66369176 NA -0.51 -6.89 -0.35 2.79e-11 Corneal structure; LUSC cis rs4595586 0.870 rs2388172 chr12:39290539 A/G cg10518543 chr12:38710700 ALG10B 0.41 5.72 0.3 2.43e-8 Morning vs. evening chronotype; LUSC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.88 -0.31 9.73e-9 Extrinsic epigenetic age acceleration; LUSC trans rs4596713 0.568 rs7850573 chr9:71747260 C/T cg25283916 chr1:242222868 NA -0.31 -6.37 -0.33 6.34e-10 Headache; LUSC cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg05340658 chr4:99064831 C4orf37 0.67 11.45 0.53 7.91e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs8017423 0.967 rs7150093 chr14:90724661 C/T cg04374321 chr14:90722782 PSMC1 -0.75 -11.86 -0.54 2.48e-27 Mortality in heart failure; LUSC cis rs11051970 0.918 rs76930558 chr12:32538839 A/C cg24626660 chr12:32551988 NA 0.38 6.07 0.32 3.43e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7119167 0.901 rs73542998 chr11:73148498 A/G cg17517138 chr11:73019481 ARHGEF17 0.49 5.72 0.3 2.33e-8 Blood protein levels; LUSC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Melanoma; LUSC cis rs1712517 0.904 rs4918007 chr10:105107470 G/A cg05636881 chr10:105038444 INA -0.38 -6.35 -0.33 6.94e-10 Migraine; LUSC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg12310025 chr6:25882481 NA -0.62 -10.33 -0.49 6.99e-22 Intelligence (multi-trait analysis); LUSC cis rs62103177 0.525 rs10438902 chr18:77745640 A/G cg20368463 chr18:77673604 PQLC1 -0.7 -7.52 -0.38 5.12e-13 Opioid sensitivity; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg16322893 chr3:107809956 CD47 -0.46 -6.82 -0.35 4.19e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9392556 0.829 rs660560 chr6:4125941 A/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -6.41 -0.33 5.08e-10 Blood metabolite levels; LUSC cis rs870825 0.616 rs7694899 chr4:185625390 C/T cg04058563 chr4:185651563 MLF1IP 0.88 13.06 0.58 9.12e-32 Blood protein levels; LUSC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.48 7.53 0.38 4.72e-13 Menarche (age at onset); LUSC cis rs16949788 0.793 rs78198355 chr15:66685808 C/T cg08120210 chr15:66682733 MAP2K1 -0.6 -5.94 -0.31 7.18e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs921665 0.681 rs6548169 chr2:3183752 A/G cg16434511 chr2:3151078 NA -0.62 -5.98 -0.31 5.74e-9 World class endurance athleticism; LUSC cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.9 13.3 0.59 1.08e-32 Multiple sclerosis; LUSC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg07362569 chr17:61921086 SMARCD2 0.38 7.82 0.39 7.02e-14 Prudent dietary pattern; LUSC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg26380479 chr7:97908229 NA -0.26 -5.8 -0.3 1.58e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs4285028 0.747 rs9852845 chr3:121390618 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.91 -12.81 -0.57 8.07e-31 Multiple sclerosis; LUSC trans rs11098499 0.697 rs4373140 chr4:120307698 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.45 -0.42 9.09e-16 Total body bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg26578400 chr12:132413450 PUS1 -0.39 -6.08 -0.32 3.24e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1395 0.778 rs11693001 chr2:27412744 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.2 0.37 4.12e-12 Blood metabolite levels; LUSC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg11764359 chr7:65958608 NA 0.81 13.59 0.6 8.62e-34 Aortic root size; LUSC cis rs9653442 0.835 rs1561230 chr2:100746642 C/T cg22139774 chr2:100720529 AFF3 0.51 9.09 0.45 9.16e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9818941 0.824 rs2712320 chr3:157770116 A/G cg08654915 chr3:157813417 NA -0.33 -7.58 -0.38 3.39e-13 Height; LUSC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg21733973 chr7:65235735 NA 0.4 5.71 0.3 2.45e-8 Calcium levels; LUSC trans rs67340775 0.541 rs169287 chr6:27854760 C/A cg06606381 chr12:133084897 FBRSL1 -0.51 -5.97 -0.31 5.95e-9 Lung cancer in ever smokers; LUSC cis rs1007190 0.881 rs12937256 chr17:42981499 C/T cg15406952 chr17:42872593 NA 0.58 5.86 0.31 1.08e-8 DNA methylation (variation); LUSC cis rs870825 0.929 rs10027213 chr4:185579871 C/G cg04058563 chr4:185651563 MLF1IP 0.82 11.48 0.53 6.36e-26 Blood protein levels; LUSC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg00343986 chr7:65444356 GUSB 0.45 6.88 0.35 3e-11 Aortic root size; LUSC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg05340658 chr4:99064831 C4orf37 0.67 11.41 0.53 1.14e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs644799 0.603 rs1255180 chr11:95472134 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.45 6.31 0.33 8.94e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg24675658 chr1:53192096 ZYG11B 0.57 9.15 0.45 5.61e-18 Monocyte count; LUSC cis rs208520 0.837 rs208489 chr6:66927584 G/A cg07460842 chr6:66804631 NA -1.03 -14.3 -0.62 1.68e-36 Exhaled nitric oxide output; LUSC trans rs2018683 0.899 rs10269454 chr7:28978400 C/T cg19402173 chr7:128379420 CALU -0.55 -8.85 -0.44 5.05e-17 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -6.06 -0.31 3.67e-9 Alzheimer's disease (late onset); LUSC cis rs1865760 1.000 rs6910138 chr6:25904352 C/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.85 0.35 3.49e-11 Height; LUSC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg11941060 chr3:133502564 NA 0.46 7.25 0.37 2.91e-12 Iron status biomarkers; LUSC cis rs9815354 0.767 rs17281182 chr3:41817263 C/T cg03022575 chr3:42003672 ULK4 0.85 8.67 0.43 1.87e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs735539 1.000 rs9506537 chr13:21280410 T/C cg27499820 chr13:21296301 IL17D -0.3 -5.76 -0.3 1.92e-8 Dental caries; LUSC cis rs7845219 0.544 rs34208552 chr8:95908067 C/G cg13393036 chr8:95962371 TP53INP1 -0.31 -5.99 -0.31 5.56e-9 Type 2 diabetes; LUSC cis rs2274273 1.000 rs61508494 chr14:55587297 T/C cg04306507 chr14:55594613 LGALS3 0.55 12.78 0.57 1.0500000000000001e-30 Protein biomarker; LUSC cis rs425277 1.000 rs196128 chr1:2078444 T/G cg24578937 chr1:2090814 PRKCZ 0.6 13.63 0.6 6e-34 Height; LUSC cis rs3782089 0.744 rs11545200 chr11:65319751 G/A cg21890820 chr11:65308645 LTBP3 1.41 9.74 0.47 6.65e-20 Height; LUSC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg00750074 chr16:89608354 SPG7 -0.46 -7.87 -0.4 4.95e-14 Multiple myeloma (IgH translocation); LUSC cis rs644799 0.526 rs542509 chr11:95641602 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.54 8.28 0.41 2.99e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs12410462 0.581 rs75219436 chr1:227546617 C/T cg23173402 chr1:227635558 NA 0.55 6.39 0.33 5.42e-10 Major depressive disorder; LUSC cis rs12893668 0.703 rs35498576 chr14:104025893 T/C cg01849466 chr14:104193079 ZFYVE21 -0.45 -6.25 -0.32 1.23e-9 Reticulocyte count; LUSC cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg24375607 chr4:120327624 NA 0.79 11.83 0.54 3.33e-27 Corneal astigmatism; LUSC cis rs60154123 0.772 rs664072 chr1:210422160 G/A cg22029157 chr1:209979665 IRF6 0.64 6.46 0.33 3.73e-10 Coronary artery disease; LUSC trans rs12478296 0.515 rs13412492 chr2:243000583 T/G cg01596870 chr19:55963115 NA -0.53 -6.86 -0.35 3.44e-11 Obesity-related traits; LUSC cis rs13394619 1.000 rs2358040 chr2:11731774 G/T cg07314298 chr2:11723111 GREB1 0.56 10.07 0.48 5.43e-21 Endometriosis; LUSC cis rs11018904 0.906 rs12793836 chr11:89953493 C/T cg26028595 chr11:89956573 CHORDC1 -0.52 -6.1 -0.32 2.96e-9 Intelligence (multi-trait analysis); LUSC cis rs9611565 0.649 rs5758442 chr22:42133060 T/C cg03806693 chr22:41940476 POLR3H 0.85 12.22 0.56 1.25e-28 Vitiligo; LUSC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg05368731 chr17:41323189 NBR1 0.84 14.22 0.61 3.22e-36 Menopause (age at onset); LUSC cis rs977987 0.872 rs4243111 chr16:75320827 C/T cg04384234 chr16:75411784 CFDP1 -0.4 -6.52 -0.34 2.56e-10 Dupuytren's disease; LUSC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg00677455 chr12:58241039 CTDSP2 0.62 8.72 0.43 1.31e-16 Multiple sclerosis; LUSC cis rs10883723 0.962 rs10883726 chr10:104236276 C/T cg05855489 chr10:104503620 C10orf26 -0.69 -9.87 -0.48 2.54e-20 Allergic disease (asthma, hay fever or eczema); LUSC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg19318889 chr4:1322082 MAEA 0.47 7.67 0.39 1.93e-13 Obesity-related traits; LUSC cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg24324837 chr19:49891574 CCDC155 0.49 7.03 0.36 1.17e-11 Multiple sclerosis; LUSC cis rs6463523 0.933 rs79984239 chr7:766220 A/G cg14391382 chr7:866102 UNC84A 0.47 7.15 0.36 5.63e-12 Subjective well-being; LUSC cis rs7178572 0.568 rs1446312 chr15:77412189 G/C cg22256960 chr15:77711686 NA -0.52 -8.1 -0.41 1.01e-14 Type 2 diabetes; LUSC cis rs909341 0.710 rs6010998 chr20:62294402 A/T cg09650180 chr20:62225654 GMEB2 0.45 5.83 0.3 1.33e-8 Atopic dermatitis; LUSC trans rs10506458 0.915 rs17763441 chr12:63418335 T/C cg22491629 chr6:157744540 C6orf35 -0.84 -10.03 -0.48 7.07e-21 Hemostatic factors and hematological phenotypes; LUSC trans rs11039798 0.844 rs6485820 chr11:48264711 A/G cg15704280 chr7:45808275 SEPT13 0.7 6.69 0.34 9.51e-11 Axial length; LUSC cis rs8040855 0.599 rs8037195 chr15:85724686 G/A cg04831495 chr15:85060580 GOLGA6L5 0.41 6.85 0.35 3.66e-11 Bulimia nervosa; LUSC trans rs4927850 0.918 rs4361313 chr3:195752260 A/G cg21051086 chr3:73046214 PPP4R2 -0.52 -7.95 -0.4 2.84e-14 Pancreatic cancer; LUSC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg06634786 chr22:41940651 POLR3H 0.49 5.76 0.3 1.91e-8 Vitiligo; LUSC trans rs4332037 1.000 rs4332037 chr7:1950809 C/T cg11693508 chr17:37793320 STARD3 0.62 7.62 0.38 2.57e-13 Bipolar disorder; LUSC cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg24596788 chr1:163392923 NA -0.45 -7.62 -0.38 2.6e-13 Motion sickness; LUSC cis rs16854884 0.586 rs7634145 chr3:143754150 G/A cg06585982 chr3:143692056 C3orf58 0.52 8.27 0.41 3.23e-15 Economic and political preferences (feminism/equality); LUSC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg12257692 chr3:49977190 RBM6 -0.26 -7.34 -0.37 1.68e-12 Intelligence (multi-trait analysis); LUSC cis rs739401 0.611 rs450817 chr11:3056712 A/G cg05729581 chr11:3078854 CARS -0.51 -7.82 -0.39 6.88e-14 Longevity; LUSC cis rs76793172 1.000 rs77461667 chr19:46341177 G/A cg27118825 chr19:46318748 RSPH6A;SYMPK 0.46 5.83 0.3 1.32e-8 Eosinophil counts; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg06387496 chr7:2775674 GNA12 -0.37 -5.71 -0.3 2.52e-8 Height; LUSC cis rs7246967 0.673 rs56725192 chr19:22810938 T/G cg23217946 chr19:22817039 ZNF492 0.45 6.33 0.33 7.68e-10 Bronchopulmonary dysplasia; LUSC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg11764359 chr7:65958608 NA -0.59 -8.19 -0.41 5.72e-15 Aortic root size; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg02155262 chr4:178363707 AGA 0.41 6.26 0.32 1.18e-9 Schizophrenia; LUSC cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg07606381 chr6:8435919 SLC35B3 0.72 12.12 0.55 2.87e-28 Motion sickness; LUSC cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -8.98 -0.44 2.04e-17 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg13072238 chr3:49761600 GMPPB 0.36 5.9 0.31 8.96e-9 Body mass index; LUSC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.09 0.45 8.99e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs4845459 0.967 rs4845454 chr1:152592184 C/T cg08895932 chr1:152778580 LCE1C -0.38 -6.48 -0.33 3.31e-10 Psoriasis; LUSC cis rs6961069 0.743 rs3211885 chr7:80289402 C/T cg04458919 chr7:80252533 CD36 -0.33 -5.91 -0.31 8.23e-9 Platelet count; LUSC cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg08807101 chr21:30365312 RNF160 -0.7 -12.14 -0.55 2.41e-28 Dental caries; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14045140 chr9:95432176 IPPK -0.5 -6.67 -0.34 1.04e-10 Hepatitis; LUSC cis rs2267681 0.544 rs1990354 chr7:139523858 A/G cg14116596 chr7:139528673 TBXAS1 0.36 6.38 0.33 5.8e-10 Cervical cancer; LUSC cis rs8017423 0.630 rs4900038 chr14:90821677 A/G cg04374321 chr14:90722782 PSMC1 -0.43 -6.51 -0.34 2.72e-10 Mortality in heart failure; LUSC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg21782813 chr7:2030301 MAD1L1 0.47 7.89 0.4 4.23e-14 Bipolar disorder and schizophrenia; LUSC cis rs2637266 1.000 rs3923670 chr10:78375001 C/G cg18941641 chr10:78392320 NA 0.38 6.94 0.36 2.04e-11 Pulmonary function; LUSC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg07777115 chr5:623756 CEP72 -0.44 -5.65 -0.3 3.47e-8 Obesity-related traits; LUSC cis rs1395 0.922 rs6547521 chr2:27488432 G/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.39 6.32 0.33 8.22e-10 Blood metabolite levels; LUSC cis rs9300255 0.770 rs28683528 chr12:123845351 C/T cg00376283 chr12:123451042 ABCB9 -0.65 -7.67 -0.39 1.91e-13 Neutrophil percentage of white cells; LUSC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.74 -13.33 -0.59 8.5e-33 Intelligence (multi-trait analysis); LUSC cis rs1534166 1.000 rs1534166 chr3:133537067 C/T cg01448562 chr3:133502909 NA -0.5 -7.28 -0.37 2.4e-12 Alcohol consumption (transferrin glycosylation); LUSC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg02269571 chr22:50332266 NA -0.56 -8.36 -0.42 1.72e-15 Schizophrenia; LUSC cis rs259282 0.669 rs731673 chr19:33132295 A/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.7 11.05 0.52 2.18e-24 Schizophrenia; LUSC cis rs727505 1.000 rs722560 chr7:124488035 T/C cg23710748 chr7:124431027 NA -0.42 -7.46 -0.38 7.65e-13 Lewy body disease; LUSC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg13206674 chr6:150067644 NUP43 0.58 9.49 0.46 4.56e-19 Lung cancer; LUSC cis rs2224391 1.000 rs2753249 chr6:5263475 T/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.46 -6.61 -0.34 1.55e-10 Height; LUSC cis rs11608355 0.545 rs7316375 chr12:109906998 G/C cg05360138 chr12:110035743 NA 0.9 11.57 0.53 2.97e-26 Neuroticism; LUSC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg00310523 chr12:86230176 RASSF9 0.54 10.05 0.48 5.93e-21 Major depressive disorder; LUSC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg00343986 chr7:65444356 GUSB 0.44 6.68 0.34 9.96e-11 Aortic root size; LUSC trans rs9944715 0.954 rs62096523 chr18:43737966 T/A cg01718231 chr17:29326311 RNF135 0.48 6.83 0.35 4.1e-11 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg24060327 chr5:131705240 SLC22A5 0.4 6.68 0.34 1.01e-10 Blood metabolite levels; LUSC cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 7.08 0.36 8.46e-12 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg24250549 chr1:154909240 PMVK 0.63 10.14 0.49 3.15e-21 Prostate cancer; LUSC cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -7.32 -0.37 1.82e-12 Menopause (age at onset); LUSC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg08888203 chr3:10149979 C3orf24 0.67 9.36 0.46 1.21e-18 Alzheimer's disease; LUSC trans rs853679 0.546 rs34194357 chr6:27818535 A/G cg06606381 chr12:133084897 FBRSL1 -1.02 -9.08 -0.44 9.93e-18 Depression; LUSC cis rs6543140 0.964 rs4851592 chr2:103087641 C/T cg09003973 chr2:102972529 NA 0.52 6.57 0.34 1.9e-10 Blood protein levels; LUSC cis rs8114671 0.562 rs7263157 chr20:33459127 G/A cg07148914 chr20:33460835 GGT7 0.56 8.34 0.42 1.99e-15 Height; LUSC cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.4e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg25173405 chr17:45401733 C17orf57 0.36 5.73 0.3 2.26e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg14092988 chr3:52407081 DNAH1 0.32 6.25 0.32 1.27e-9 Bipolar disorder; LUSC cis rs9911578 0.835 rs1476596 chr17:56485358 C/T cg05425664 chr17:57184151 TRIM37 -0.52 -8.16 -0.41 6.78e-15 Intelligence (multi-trait analysis); LUSC cis rs80130819 0.515 rs7315258 chr12:48572670 T/C cg24011408 chr12:48396354 COL2A1 0.48 6.57 0.34 1.96e-10 Prostate cancer; LUSC cis rs3126085 0.825 rs7535078 chr1:152222915 T/C cg03465714 chr1:152285911 FLG -0.41 -5.79 -0.3 1.64e-8 Atopic dermatitis; LUSC cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg03676636 chr4:99064102 C4orf37 0.34 7.33 0.37 1.73e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg17971929 chr21:40555470 PSMG1 0.8 14.27 0.62 2.18e-36 Cognitive function; LUSC cis rs6088590 1.000 rs6120748 chr20:33458284 T/G cg08999081 chr20:33150536 PIGU 0.46 8.3 0.41 2.52e-15 Coronary artery disease; LUSC cis rs1348850 0.526 rs7582179 chr2:178370631 A/G cg22681709 chr2:178499509 PDE11A -0.47 -6.88 -0.35 2.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg13939156 chr17:80058883 NA 0.33 6.48 0.33 3.3e-10 Life satisfaction; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06116271 chr12:120906938 DYNLL1;SFRS9 0.42 6.14 0.32 2.39e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs8078723 1.000 rs4794824 chr17:38179290 G/A cg17467752 chr17:38218738 THRA 0.75 11.81 0.54 3.96e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9987353 0.566 rs34491841 chr8:9065510 C/A cg06636001 chr8:8085503 FLJ10661 -0.46 -6.45 -0.33 3.97e-10 Recombination measurement; LUSC cis rs2953145 0.568 rs1133354 chr2:241522450 A/G cg03371404 chr2:241525653 CAPN10 -0.41 -5.87 -0.31 1.06e-8 Bipolar disorder; LUSC trans rs7657257 1.000 rs10516290 chr4:15732456 T/C cg17675199 chr6:35436792 RPL10A -0.83 -6.11 -0.32 2.84e-9 Blood protein levels; LUSC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.63 -13.61 -0.6 7.18e-34 Hemoglobin concentration; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg10484450 chr14:67982152 TMEM229B 0.44 6.29 0.33 9.77e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg11742103 chr11:62369870 EML3;MTA2 0.55 8.99 0.44 1.84e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs57046232 0.552 rs1998971 chr20:6334912 G/A cg21095983 chr6:86352623 SYNCRIP 0.47 7.08 0.36 8.33e-12 Colorectal cancer; LUSC cis rs12900413 0.687 rs35562959 chr15:90310537 C/T cg24249390 chr15:90295951 MESP1 -0.37 -5.91 -0.31 8.6e-9 Coronary artery aneurysm in Kawasaki disease; LUSC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg21573476 chr21:45109991 RRP1B -0.37 -5.97 -0.31 5.94e-9 Mean corpuscular volume; LUSC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg06454157 chr6:167490870 NA -0.26 -6.1 -0.32 2.86e-9 Crohn's disease; LUSC cis rs4692589 0.531 rs12650424 chr4:170975204 T/C cg19918862 chr4:170955249 NA 0.38 6.74 0.35 6.91e-11 Anxiety disorder; LUSC cis rs10266483 0.739 rs679966 chr7:63767066 C/T cg24201672 chr7:64023550 ZNF680 -0.49 -6.56 -0.34 2.03e-10 Response to statin therapy; LUSC cis rs4253772 0.938 rs45550937 chr22:46638128 C/G cg09491104 chr22:46646882 C22orf40 -0.59 -6.48 -0.33 3.23e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs1577917 0.958 rs13201730 chr6:86556647 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.72 -0.35 7.84e-11 Response to antipsychotic treatment; LUSC cis rs11190604 1.000 rs2489037 chr10:102319918 A/G cg16342193 chr10:102329863 NA 0.39 6.73 0.35 7.23e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs3540 0.574 rs2657947 chr15:90968977 C/T cg10434728 chr15:90938212 IQGAP1 -0.4 -8.34 -0.42 1.95e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs8060686 0.641 rs75450962 chr16:68210868 C/T cg04539111 chr16:67997858 SLC12A4 -0.44 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg10802521 chr3:52805072 NEK4 -0.47 -6.79 -0.35 5.23e-11 Bipolar disorder; LUSC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg24110177 chr3:50126178 RBM5 0.56 9.15 0.45 5.78e-18 Intelligence (multi-trait analysis); LUSC cis rs6163 0.588 rs11191392 chr10:104526951 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.43 -6.4 -0.33 5.2e-10 Waist circumference;Hip circumference; LUSC trans rs11098499 0.954 rs12506546 chr4:120301618 T/C cg25214090 chr10:38739885 LOC399744 0.56 8.06 0.4 1.33e-14 Corneal astigmatism; LUSC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg16434002 chr17:42200994 HDAC5 0.44 5.95 0.31 6.85e-9 Total body bone mineral density; LUSC cis rs9393777 0.588 rs9467772 chr6:26496578 A/T cg12292205 chr6:26970375 C6orf41 -0.6 -7.39 -0.37 1.17e-12 Intelligence (multi-trait analysis); LUSC cis rs7588746 0.621 rs10497859 chr2:201144446 G/A cg23649088 chr2:200775458 C2orf69 -0.41 -5.86 -0.31 1.13e-8 Bipolar disorder lithium response (continuous) or schizophrenia; LUSC cis rs3106136 0.527 rs4693376 chr4:95157240 A/G cg11021082 chr4:95130006 SMARCAD1 -0.44 -8.03 -0.4 1.71e-14 Capecitabine sensitivity; LUSC cis rs9790314 1.000 rs7638668 chr3:161047283 G/A cg04691961 chr3:161091175 C3orf57 -0.35 -6.11 -0.32 2.74e-9 Morning vs. evening chronotype; LUSC cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg25173405 chr17:45401733 C17orf57 -0.38 -6.12 -0.32 2.6e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7267979 0.899 rs2179459 chr20:25456141 C/A cg08601574 chr20:25228251 PYGB 0.38 5.68 0.3 2.88e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1003719 0.715 rs2835613 chr21:38496883 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.69 -10.76 -0.51 2.14e-23 Eye color traits; LUSC cis rs28830936 1.000 rs4923905 chr15:41909889 G/A cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.31 -0.33 8.93e-10 Diastolic blood pressure; LUSC cis rs1448094 0.872 rs12322940 chr12:86406708 G/C cg02569458 chr12:86230093 RASSF9 0.38 6.07 0.32 3.45e-9 Major depressive disorder; LUSC trans rs6076960 0.684 rs3909086 chr20:6251639 A/G cg17788362 chr6:86352627 SYNCRIP 0.45 6.48 0.33 3.31e-10 Smooth-surface caries; LUSC cis rs10979 1.000 rs12215667 chr6:143893213 T/C cg25407410 chr6:143891975 LOC285740 -0.74 -12.13 -0.55 2.58e-28 Hypospadias; LUSC cis rs2739330 0.703 rs5760112 chr22:24259772 C/G cg12419862 chr22:24373484 LOC391322 -1.02 -19.51 -0.73 4.07e-57 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg24692254 chr21:30365293 RNF160 -0.72 -11.11 -0.52 1.29e-24 Pancreatic cancer; LUSC cis rs2290159 0.948 rs7956 chr3:12624763 C/T cg23032965 chr3:12705835 RAF1 -0.54 -7.04 -0.36 1.12e-11 Cholesterol, total; LUSC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg09267113 chr7:98030324 BAIAP2L1 0.38 5.83 0.3 1.29e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs7223966 1.000 rs9901112 chr17:61730617 C/G cg00945038 chr17:61921165 SMARCD2 0.39 5.8 0.3 1.56e-8 Hip circumference adjusted for BMI;Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg21809942 chr18:45456743 SMAD2 0.47 6.24 0.32 1.35e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg09467607 chr2:36825704 FEZ2 -0.52 -11.46 -0.53 7.4e-26 Height; LUSC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg17211192 chr8:82754475 SNX16 0.6 8.54 0.42 4.71e-16 Diastolic blood pressure; LUSC cis rs981844 0.885 rs62325082 chr4:154661274 A/G cg14289246 chr4:154710475 SFRP2 0.5 6.44 0.33 4.05e-10 Response to statins (LDL cholesterol change); LUSC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg03676636 chr4:99064102 C4orf37 0.34 7.46 0.38 7.58e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg01448562 chr3:133502909 NA 0.65 10.41 0.49 3.69e-22 Iron status biomarkers; LUSC trans rs11098499 0.954 rs10518331 chr4:120323595 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.48 6.39 0.33 5.42e-10 Corneal astigmatism; LUSC trans rs2243480 1.000 rs1499614 chr7:65730798 A/T cg10756647 chr7:56101905 PSPH 0.87 8.68 0.43 1.74e-16 Diabetic kidney disease; LUSC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg11062466 chr8:58055876 NA 0.59 7.34 0.37 1.65e-12 Developmental language disorder (linguistic errors); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg13030586 chr4:186347098 UFSP2 0.83 6.75 0.35 6.6e-11 Cognitive performance; LUSC cis rs9814567 1.000 rs9827987 chr3:134272621 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.68 -0.6 3.86e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg08470875 chr2:26401718 FAM59B -0.72 -9.9 -0.48 1.91e-20 Gut microbiome composition (summer); LUSC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg22166914 chr1:53195759 ZYG11B -0.4 -5.92 -0.31 8.17e-9 Monocyte count; LUSC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg25251562 chr2:3704773 ALLC -0.71 -10.96 -0.51 4.38e-24 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC trans rs6582630 0.513 rs1596446 chr12:38282160 C/T cg06521331 chr12:34319734 NA 0.41 6.57 0.34 1.99e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg23034840 chr1:205782522 SLC41A1 0.69 9.76 0.47 5.75e-20 Prostate-specific antigen levels; LUSC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg11062466 chr8:58055876 NA 0.7 8.6 0.43 3.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg07153921 chr17:41440717 NA -0.39 -5.75 -0.3 2.02e-8 Menopause (age at onset); LUSC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg25566285 chr7:158114605 PTPRN2 0.31 5.85 0.3 1.2e-8 Calcium levels; LUSC trans rs11992162 0.507 rs60902764 chr8:11784991 A/T cg15556689 chr8:8085844 FLJ10661 -0.46 -6.54 -0.34 2.37e-10 Monocyte count; LUSC cis rs9815354 0.812 rs12108049 chr3:41958161 A/G cg03022575 chr3:42003672 ULK4 0.83 8.69 0.43 1.66e-16 Pulse pressure;Diastolic blood pressure; LUSC trans rs475616 0.917 rs866919 chr10:30513283 C/T cg01438892 chr2:61108274 REL -0.43 -6.58 -0.34 1.83e-10 Monocyte count; LUSC cis rs7617773 0.817 rs11130163 chr3:48312658 T/C cg11946769 chr3:48343235 NME6 0.75 11.45 0.53 7.65e-26 Coronary artery disease; LUSC cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg12011299 chr4:100065546 ADH4 0.65 11.03 0.52 2.48e-24 Alcohol dependence; LUSC cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg16339924 chr4:17578868 LAP3 -0.57 -8.22 -0.41 4.6e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6835098 0.924 rs13138282 chr4:174120906 C/T cg27433088 chr4:174089019 GALNT7 -0.39 -5.67 -0.3 3.14e-8 Dementia and core Alzheimer's disease neuropathologic changes; LUSC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs9287719 0.745 rs4997810 chr2:10755540 T/A cg00105475 chr2:10696890 NA 0.36 5.81 0.3 1.42e-8 Prostate cancer; LUSC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg11752832 chr7:134001865 SLC35B4 0.59 9.09 0.45 8.87e-18 Mean platelet volume; LUSC cis rs11971779 0.680 rs3924445 chr7:139044172 C/A cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg24558204 chr6:135376177 HBS1L 0.68 10.41 0.49 3.78e-22 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs2637266 1.000 rs12260379 chr10:78365036 C/T cg18941641 chr10:78392320 NA 0.39 7.11 0.36 7.28e-12 Pulmonary function; LUSC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.53 6.86 0.35 3.43e-11 Multiple sclerosis; LUSC trans rs372883 0.648 rs1153288 chr21:30686091 A/G cg14791747 chr16:20752902 THUMPD1 -0.42 -5.95 -0.31 6.66e-9 Pancreatic cancer; LUSC trans rs7951105 1.000 rs7937705 chr11:39247947 T/G cg24085930 chr3:21832523 NA 0.49 6.06 0.31 3.58e-9 Free thyroxine concentration; LUSC cis rs8141529 0.732 rs2239815 chr22:29192670 C/T cg02153584 chr22:29168773 CCDC117 -0.64 -9.94 -0.48 1.43e-20 Lymphocyte counts; LUSC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg00310523 chr12:86230176 RASSF9 0.43 7.72 0.39 1.38e-13 Major depressive disorder; LUSC cis rs7428496 0.528 rs2227929 chr3:142277536 C/T cg16271453 chr3:142027066 XRN1 0.47 8.37 0.42 1.57e-15 Mean corpuscular hemoglobin; LUSC cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg05985134 chr18:33552581 C18orf21 0.5 7.07 0.36 8.86e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg08807101 chr21:30365312 RNF160 -0.67 -10.36 -0.49 5.32e-22 Pancreatic cancer; LUSC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg13395646 chr4:1353034 KIAA1530 -0.64 -10.15 -0.49 2.88e-21 Obesity-related traits; LUSC cis rs5769765 0.954 rs5770709 chr22:50245196 G/T cg08270630 chr22:50330655 NA 0.41 6.06 0.31 3.64e-9 Schizophrenia; LUSC cis rs7091068 0.518 rs4144098 chr10:95432600 C/T cg20715218 chr10:95462985 C10orf4 0.46 5.88 0.31 1.01e-8 Urinary tract infection frequency; LUSC cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg09934977 chr17:18586148 ZNF286B 0.42 6.65 0.34 1.17e-10 Educational attainment (years of education); LUSC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg11645453 chr3:52864694 ITIH4 0.36 8.37 0.42 1.55e-15 Bipolar disorder; LUSC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg05729581 chr11:3078854 CARS -0.57 -8.31 -0.41 2.52e-15 Longevity; LUSC cis rs12956009 0.583 rs919979 chr18:44902739 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.19 0.32 1.74e-9 Educational attainment (years of education); LUSC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 10.52 0.5 1.53e-22 Hip circumference adjusted for BMI; LUSC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg14668632 chr7:2872130 GNA12 -0.45 -6.41 -0.33 4.94e-10 Height; LUSC cis rs3096299 1.000 rs3096299 chr16:89448663 G/A cg08392591 chr16:89556376 ANKRD11 0.38 5.67 0.3 3.16e-8 Multiple myeloma (IgH translocation); LUSC cis rs11650494 0.516 rs4640235 chr17:47502352 T/C cg08112188 chr17:47440006 ZNF652 1.07 8.76 0.43 1.01e-16 Prostate cancer; LUSC trans rs62103177 0.733 rs62096747 chr18:77619568 A/G cg05926928 chr17:57297772 GDPD1 1.43 17.45 0.69 6.4e-49 Opioid sensitivity; LUSC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg05896524 chr21:47604654 C21orf56 0.53 8.14 0.41 7.98e-15 Testicular germ cell tumor; LUSC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.17 0.32 2.01e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs832540 0.866 rs252894 chr5:56224339 A/C cg18230493 chr5:56204884 C5orf35 0.46 6.06 0.31 3.76e-9 Coronary artery disease; LUSC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg11062466 chr8:58055876 NA 0.64 8.49 0.42 6.73e-16 Developmental language disorder (linguistic errors); LUSC cis rs6429082 0.818 rs696248 chr1:235668511 C/A cg26050004 chr1:235667680 B3GALNT2 0.61 8.06 0.4 1.41e-14 Adiposity; LUSC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg05234568 chr11:5960015 NA -0.57 -8.33 -0.41 2.1e-15 DNA methylation (variation); LUSC trans rs2204008 0.774 rs4534658 chr12:38246783 G/A cg06521331 chr12:34319734 NA -0.4 -6.19 -0.32 1.74e-9 Bladder cancer; LUSC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg02269571 chr22:50332266 NA -0.59 -8.72 -0.43 1.31e-16 Schizophrenia; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg07001414 chr14:21457871 METT11D1 0.5 6.94 0.36 2.04e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg00908189 chr16:619842 PIGQ 0.66 10.15 0.49 2.75e-21 Height; LUSC trans rs208520 1.000 rs28773210 chr6:66993566 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 11.93 0.55 1.4e-27 Exhaled nitric oxide output; LUSC cis rs9650315 0.929 rs35928074 chr8:57168612 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.51 7.12 0.36 6.82e-12 Height; LUSC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg21361702 chr7:150065534 REPIN1 0.5 6.87 0.35 3.09e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg25985355 chr7:65971099 NA -0.36 -5.68 -0.3 2.94e-8 Aortic root size; LUSC trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21659725 chr3:3221576 CRBN -0.59 -8.27 -0.41 3.21e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs9400467 0.528 rs455247 chr6:111667799 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -6.94 -0.35 2.09e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg25319279 chr11:5960081 NA 0.38 6.25 0.32 1.27e-9 DNA methylation (variation); LUSC trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC cis rs11098499 0.954 rs1022145 chr4:120230979 A/G cg09307838 chr4:120376055 NA 0.8 11.48 0.53 6.19e-26 Corneal astigmatism; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg12225893 chr2:86115700 ST3GAL5 0.42 6.08 0.32 3.22e-9 Mosquito bite size; LUSC cis rs60154123 0.772 rs815358 chr1:210430437 A/G cg22029157 chr1:209979665 IRF6 0.58 5.93 0.31 7.41e-9 Coronary artery disease; LUSC cis rs1348850 0.958 rs11689550 chr2:178456298 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.08 0.32 3.23e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs17784882 0.521 rs11713693 chr3:47074906 T/C cg27129171 chr3:47204927 SETD2 -0.69 -10.9 -0.51 7.07e-24 QT interval; LUSC cis rs9916302 0.861 rs7503514 chr17:37669884 G/C cg07936489 chr17:37558343 FBXL20 -0.7 -9.54 -0.46 3.03e-19 Glomerular filtration rate (creatinine); LUSC trans rs35110281 0.774 rs2838327 chr21:45018566 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.48 0.46 4.93e-19 Mean corpuscular volume; LUSC cis rs4805834 0.640 rs11671862 chr19:33304298 C/T cg00891608 chr19:33463040 C19orf40;CCDC123 -0.56 -5.71 -0.3 2.48e-8 Creatinine levels; LUSC cis rs2742417 1.000 rs9829631 chr3:45740558 T/C cg09608765 chr3:45636137 LIMD1 -0.38 -7.42 -0.38 9.93e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg05347473 chr6:146136440 FBXO30 -0.56 -9.71 -0.47 8.3e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg20283391 chr11:68216788 NA -0.54 -7.99 -0.4 2.27e-14 Total body bone mineral density; LUSC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs981844 0.712 rs878911 chr4:154755615 A/G cg14289246 chr4:154710475 SFRP2 -0.46 -6.41 -0.33 4.85e-10 Response to statins (LDL cholesterol change); LUSC trans rs11992162 0.551 rs59191504 chr8:11785081 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -6.28 -0.32 1.02e-9 Monocyte count; LUSC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.8 -0.35 4.82e-11 Alzheimer's disease (late onset); LUSC trans rs6598955 0.627 rs6684875 chr1:26567044 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.64 -8.8 -0.43 7.56e-17 Obesity-related traits; LUSC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg02574844 chr11:5959923 NA -0.43 -6.14 -0.32 2.37e-9 DNA methylation (variation); LUSC cis rs7267979 1.000 rs6083825 chr20:25366424 T/C cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9309473 0.632 rs6706179 chr2:73578577 C/T cg20560298 chr2:73613845 ALMS1 -0.55 -8.1 -0.41 1.05e-14 Metabolite levels; LUSC cis rs4319547 0.508 rs10846826 chr12:122894987 C/T cg23029597 chr12:123009494 RSRC2 -0.72 -9.25 -0.45 2.74e-18 Body mass index; LUSC cis rs7208859 0.623 rs55961983 chr17:29119286 G/A cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs5769707 0.642 rs4824070 chr22:50031521 T/C cg20744362 chr22:50050164 C22orf34 0.39 7.15 0.36 5.37e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg13560548 chr3:10150139 C3orf24 0.52 7.46 0.38 7.33e-13 Alzheimer's disease; LUSC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg12560992 chr17:57184187 TRIM37 0.83 15.44 0.65 5.86e-41 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2749705 chr1:231526696 C/T cg06096015 chr1:231504339 EGLN1 0.57 9.93 0.48 1.56e-20 Hemoglobin concentration; LUSC cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg00152838 chr16:24741724 TNRC6A 0.47 5.74 0.3 2.07e-8 Intelligence (multi-trait analysis); LUSC cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.55 0.42 4.57e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.42 6.58 0.34 1.79e-10 Bone mineral density (spine);Bone mineral density; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19877581 chr12:62654212 USP15 -0.41 -6.0 -0.31 5.1e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9303401 0.659 rs56162835 chr17:56687315 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.91 0.61 5.12e-35 Cognitive test performance; LUSC cis rs10089 1.000 rs11957052 chr5:127524055 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.85 11.53 0.53 3.91e-26 Ileal carcinoids; LUSC trans rs75804782 0.641 rs112066551 chr2:239362486 G/A cg01134436 chr17:81009848 B3GNTL1 0.64 6.16 0.32 2.14e-9 Morning vs. evening chronotype;Chronotype; LUSC cis rs3782089 0.744 rs11545200 chr11:65319751 G/A cg08676812 chr11:65308423 LTBP3 1.06 6.8 0.35 4.79e-11 Height; LUSC cis rs7940866 0.834 rs10894298 chr11:130840571 C/A cg12179176 chr11:130786555 SNX19 0.6 8.97 0.44 2.13e-17 Schizophrenia; LUSC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 7.89e-25 Mean corpuscular volume; LUSC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg07424592 chr7:64974309 NA -0.63 -5.65 -0.3 3.53e-8 Diabetic kidney disease; LUSC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg02569458 chr12:86230093 RASSF9 -0.48 -7.95 -0.4 2.87e-14 Major depressive disorder; LUSC cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg26395211 chr5:140044315 WDR55 0.45 7.01 0.36 1.29e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs4604732 0.578 rs7525209 chr1:247627404 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.41 0.33 5.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg17366294 chr4:99064904 C4orf37 0.56 9.83 0.47 3.29e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.14 -0.49 3.1e-21 Developmental language disorder (linguistic errors); LUSC cis rs9796 0.636 rs1983400 chr15:41373029 T/C cg18705301 chr15:41695430 NDUFAF1 -0.47 -8.29 -0.41 2.84e-15 Menopause (age at onset); LUSC cis rs4820294 0.646 rs9622675 chr22:38053665 G/T cg21798802 chr22:38057573 PDXP 0.32 6.64 0.34 1.24e-10 Fat distribution (HIV); LUSC cis rs11025559 0.812 rs10833338 chr11:20514709 A/G cg19653624 chr11:20408972 PRMT3 -0.67 -8.48 -0.42 7.28e-16 Pursuit maintenance gain; LUSC cis rs67696533 1.000 rs6119893 chr20:31142813 G/T cg13636640 chr20:31349939 DNMT3B 0.47 6.86 0.35 3.28e-11 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs193541 0.626 rs4835881 chr5:122088040 G/T cg19077854 chr5:122220652 SNX24 0.27 6.16 0.32 2.12e-9 Glucose homeostasis traits; LUSC trans rs3857536 0.544 rs208453 chr6:66906841 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.74 -10.08 -0.48 4.95e-21 Blood trace element (Cu levels); LUSC cis rs11153306 0.529 rs11153303 chr6:111937875 G/A cg22127309 chr6:111907043 TRAF3IP2 -0.37 -7.17 -0.37 4.83e-12 Tonsillectomy; LUSC cis rs7267979 0.816 rs6115094 chr20:25210827 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.69 13.22 0.59 2.26e-32 Liver enzyme levels (alkaline phosphatase); LUSC cis rs600231 0.665 rs1621277 chr11:65221954 A/G cg17120908 chr11:65337727 SSSCA1 0.55 9.67 0.47 1.17e-19 Bone mineral density; LUSC cis rs9911578 0.835 rs3744093 chr17:56492800 T/C cg12560992 chr17:57184187 TRIM37 -0.71 -12.19 -0.56 1.54e-28 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg07606381 chr6:8435919 SLC35B3 0.74 12.56 0.57 6.56e-30 Motion sickness; LUSC cis rs134594 0.961 rs134604 chr22:29474077 A/G cg03665785 chr22:29458676 C22orf31 0.28 5.75 0.3 1.96e-8 Birth weight; LUSC cis rs6693567 0.565 rs834237 chr1:150363930 A/G cg15654264 chr1:150340011 RPRD2 0.45 7.18 0.37 4.62e-12 Migraine; LUSC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.7 10.52 0.5 1.5e-22 Monocyte percentage of white cells; LUSC cis rs12421382 0.659 rs1371330 chr11:109382692 G/T cg11473876 chr11:109292803 C11orf87 0.4 6.52 0.34 2.59e-10 Schizophrenia; LUSC trans rs11098499 0.863 rs10018280 chr4:120478139 T/G cg25214090 chr10:38739885 LOC399744 0.52 7.7 0.39 1.51e-13 Corneal astigmatism; LUSC cis rs12950390 0.853 rs66471233 chr17:45867086 C/T cg03474202 chr17:45855739 NA -0.31 -6.99 -0.36 1.52e-11 IgG glycosylation; LUSC cis rs7618501 0.735 rs9876508 chr3:49780844 G/A cg12257692 chr3:49977190 RBM6 -0.21 -5.7 -0.3 2.69e-8 Intelligence (multi-trait analysis); LUSC cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.51 6.53 0.34 2.41e-10 Multiple sclerosis; LUSC cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.57 0.38 3.77e-13 Motion sickness; LUSC cis rs3540 0.512 rs7176518 chr15:91079637 C/T cg10434728 chr15:90938212 IQGAP1 -0.45 -9.3 -0.45 1.9e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg14416269 chr4:6271139 WFS1 0.51 10.61 0.5 7.27e-23 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg15691649 chr6:25882328 NA -0.51 -7.74 -0.39 1.21e-13 Blood metabolite levels; LUSC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg11645453 chr3:52864694 ITIH4 0.36 8.1 0.41 1.03e-14 Bipolar disorder; LUSC cis rs7647973 0.710 rs9869120 chr3:49624065 T/C cg07636037 chr3:49044803 WDR6 0.56 5.73 0.3 2.24e-8 Menarche (age at onset); LUSC cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg14582100 chr15:45693742 SPATA5L1 0.49 8.44 0.42 9.51e-16 Homoarginine levels; LUSC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg07870213 chr5:140052090 DND1 -0.76 -11.27 -0.52 3.37e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs73198271 1.000 rs55971558 chr8:8614403 G/T cg15556689 chr8:8085844 FLJ10661 -0.49 -5.81 -0.3 1.42e-8 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg14530993 chr4:882597 GAK 0.76 7.51 0.38 5.35e-13 Intelligence (multi-trait analysis); LUSC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg14262678 chr6:151773367 RMND1;C6orf211 0.46 7.47 0.38 6.99e-13 Menarche (age at onset); LUSC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg22638593 chr5:131593259 PDLIM4 0.45 6.77 0.35 5.75e-11 Acylcarnitine levels; LUSC cis rs6546550 0.900 rs2054047 chr2:70117421 A/C cg02498382 chr2:70120550 SNRNP27 -0.31 -7.58 -0.38 3.55e-13 Prevalent atrial fibrillation; LUSC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.91 -0.35 2.41e-11 Lung cancer; LUSC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg21724239 chr8:58056113 NA 0.58 6.68 0.34 9.96e-11 Developmental language disorder (linguistic errors); LUSC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg23791538 chr6:167370224 RNASET2 0.36 5.67 0.3 3.14e-8 Crohn's disease; LUSC cis rs7296418 0.580 rs78455769 chr12:123856443 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -6.41 -0.33 4.96e-10 Platelet count; LUSC cis rs2486288 0.656 rs12904150 chr15:45547605 T/C cg09092052 chr15:45571596 NA 0.46 6.41 0.33 5.09e-10 Glomerular filtration rate; LUSC cis rs6933660 0.744 rs35143743 chr6:151768532 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.54 7.09 0.36 8.24e-12 Menarche (age at onset); LUSC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg26695010 chr11:65641043 EFEMP2 0.43 6.05 0.31 3.92e-9 Breast cancer; LUSC cis rs7937682 0.924 rs7938360 chr11:111539875 A/G cg09085632 chr11:111637200 PPP2R1B -1.11 -18.25 -0.71 4.33e-52 Primary sclerosing cholangitis; LUSC cis rs10986311 0.775 rs7872979 chr9:127104412 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.9 0.35 2.59e-11 Vitiligo; LUSC cis rs11758351 1.000 rs79264785 chr6:26194121 C/T cg01420254 chr6:26195488 NA 0.71 7.5 0.38 5.86e-13 Gout;Renal underexcretion gout; LUSC trans rs62238980 0.614 rs118073663 chr22:32397610 A/T cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.53 -6.0 -0.31 5e-9 Childhood ear infection; LUSC trans rs7726839 0.574 rs72705014 chr5:619815 C/G cg11887960 chr12:57824829 NA 0.54 6.67 0.34 1.08e-10 Obesity-related traits; LUSC cis rs17155006 0.746 rs446800 chr7:107747928 A/C cg05962710 chr7:107745446 LAMB4 -0.36 -6.52 -0.34 2.57e-10 Pneumococcal bacteremia; LUSC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg11764359 chr7:65958608 NA -0.49 -6.24 -0.32 1.32e-9 Aortic root size; LUSC cis rs6700896 0.931 rs10749755 chr1:66129530 C/T cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg27494647 chr7:150038898 RARRES2 0.58 8.54 0.42 4.73e-16 Blood protein levels;Circulating chemerin levels; LUSC cis rs72781680 0.665 rs2953028 chr2:24068126 T/C cg08917208 chr2:24149416 ATAD2B 0.62 7.1 0.36 7.32e-12 Lymphocyte counts; LUSC cis rs748404 0.578 rs552701 chr15:43613810 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.6 9.23 0.45 3.22e-18 Lung cancer; LUSC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 6.19 0.32 1.81e-9 Bipolar disorder; LUSC cis rs9527 0.590 rs12246739 chr10:104787019 A/C cg23093090 chr10:104574429 C10orf26 0.32 5.87 0.31 1.06e-8 Arsenic metabolism; LUSC cis rs4629180 0.651 rs9653468 chr2:102108403 A/G cg04415270 chr2:102091202 RFX8 -0.44 -7.6 -0.38 2.94e-13 Chronic rhinosinusitis with nasal polyps; LUSC trans rs7824557 0.583 rs4448232 chr8:11231354 G/T cg15556689 chr8:8085844 FLJ10661 0.55 8.32 0.41 2.32e-15 Retinal vascular caliber; LUSC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.67 -11.44 -0.53 8.43e-26 IgG glycosylation; LUSC cis rs427941 0.703 rs201455 chr7:101740212 C/T cg06246474 chr7:101738831 CUX1 0.39 6.34 0.33 7.52e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); LUSC cis rs4363385 0.719 rs12748969 chr1:152932654 T/C cg00922841 chr1:152955080 SPRR1A -0.4 -6.59 -0.34 1.72e-10 Inflammatory skin disease; LUSC cis rs62244186 0.714 rs2293600 chr3:44599103 G/T cg18165381 chr3:44552316 NA 0.38 6.33 0.33 7.76e-10 Depressive symptoms; LUSC cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg23029597 chr12:123009494 RSRC2 -0.7 -9.52 -0.46 3.54e-19 Body mass index; LUSC cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.07 0.48 5.08e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs5769707 0.967 rs9616701 chr22:50025546 G/A cg10356904 chr22:49881777 NA -0.33 -7.39 -0.37 1.21e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg21880101 chr17:80066754 CCDC57 -0.31 -5.8 -0.3 1.54e-8 Life satisfaction; LUSC cis rs965469 0.843 rs6051842 chr20:3397434 T/C cg25506879 chr20:3388711 C20orf194 -0.52 -5.64 -0.3 3.57e-8 IFN-related cytopenia; LUSC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg22963979 chr7:1858916 MAD1L1 -0.56 -8.41 -0.42 1.18e-15 Bipolar disorder and schizophrenia; LUSC trans rs6594499 0.778 rs3806932 chr5:110405675 C/T cg09098825 chr3:47866946 DHX30 0.49 6.0 0.31 5.02e-9 Allergic disease (asthma, hay fever or eczema); LUSC cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.76 12.07 0.55 4.41e-28 Colorectal cancer; LUSC cis rs939574 0.656 rs6710315 chr2:220137991 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.79 -6.36 -0.33 6.6e-10 Platelet distribution width; LUSC cis rs568617 1.000 rs693824 chr11:65654783 A/G cg19792802 chr11:65647270 CTSW 0.41 6.23 0.32 1.38e-9 Crohn's disease; LUSC cis rs9790314 0.503 rs6441374 chr3:161064540 A/T cg03342759 chr3:160939853 NMD3 -0.42 -6.21 -0.32 1.59e-9 Morning vs. evening chronotype; LUSC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.51 8.62 0.43 2.69e-16 Prudent dietary pattern; LUSC cis rs4478858 0.839 rs10798834 chr1:31708977 G/A cg00250761 chr1:31883323 NA -0.38 -9.89 -0.48 2.13e-20 Alcohol dependence; LUSC cis rs2439831 1.000 rs28666488 chr15:43741090 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.87 9.03 0.44 1.35e-17 Lung cancer in ever smokers; LUSC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.88 0.51 8.25e-24 Hip circumference adjusted for BMI; LUSC cis rs9549367 0.789 rs9604040 chr13:113910611 A/G cg00898013 chr13:113819073 PROZ 0.49 7.29 0.37 2.33e-12 Platelet distribution width; LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg08859206 chr1:53392774 SCP2 -0.68 -12.84 -0.58 5.79e-31 Monocyte count; LUSC cis rs2204008 0.837 rs1842599 chr12:37986081 G/A cg13010199 chr12:38710504 ALG10B -0.62 -9.58 -0.46 2.28e-19 Bladder cancer; LUSC trans rs79057730 0.528 rs6965219 chr7:821807 C/G cg26647312 chr5:1645268 NA 0.59 5.95 0.31 6.91e-9 Initial pursuit acceleration; LUSC cis rs73416724 1.000 rs73416724 chr6:43337802 A/G cg26312998 chr6:43337775 ZNF318 0.57 6.62 0.34 1.4e-10 Autism spectrum disorder or schizophrenia; LUSC trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21659725 chr3:3221576 CRBN -0.58 -8.34 -0.42 1.92e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs10464366 0.746 rs11760807 chr7:39142377 G/A cg21665744 chr7:39171113 POU6F2 0.44 6.67 0.34 1.08e-10 IgG glycosylation; LUSC cis rs2836633 0.929 rs58120977 chr21:40037346 C/T cg12884169 chr21:40033163 ERG 0.61 12.33 0.56 4.83e-29 Coronary artery disease; LUSC trans rs1362931 0.543 rs17288905 chr6:46683382 A/G cg01218148 chr9:34523776 ENHO 0.63 6.04 0.31 4.02e-9 Lipoprotein-associated phospholipase A2 activity and mass; LUSC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg23711669 chr6:146136114 FBXO30 0.87 15.89 0.66 9.56e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg02569458 chr12:86230093 RASSF9 0.48 7.69 0.39 1.65e-13 Major depressive disorder; LUSC cis rs6700896 0.931 rs1938490 chr1:66132800 T/A cg04111102 chr1:66153794 NA 0.33 7.26 0.37 2.81e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs7939886 0.920 rs17150117 chr11:55941186 T/C cg15704280 chr7:45808275 SEPT13 0.88 6.69 0.34 9.39e-11 Myopia (pathological); LUSC cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg26384229 chr12:38710491 ALG10B 0.88 15.05 0.64 1.94e-39 Bladder cancer; LUSC cis rs765787 0.530 rs11070445 chr15:45513163 T/A cg24006582 chr15:45444508 DUOX1 0.67 9.67 0.47 1.16e-19 Uric acid levels; LUSC cis rs9611519 0.761 rs35445172 chr22:41660301 G/A cg03806693 chr22:41940476 POLR3H -0.56 -8.26 -0.41 3.45e-15 Neuroticism; LUSC cis rs9303401 0.580 rs12603808 chr17:56578508 T/G cg25039879 chr17:56429692 SUPT4H1 0.72 9.66 0.47 1.21e-19 Cognitive test performance; LUSC cis rs394563 0.663 rs415434 chr6:149772645 A/G cg16235748 chr6:149772707 ZC3H12D -0.3 -6.08 -0.32 3.26e-9 Dupuytren's disease; LUSC cis rs7659604 0.502 rs4315813 chr4:122674866 G/A cg19748678 chr4:122722346 EXOSC9 -0.4 -5.91 -0.31 8.47e-9 Type 2 diabetes; LUSC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg25428297 chr7:1022841 CYP2W1 0.28 5.74 0.3 2.11e-8 Longevity;Endometriosis; LUSC cis rs2180341 0.538 rs11154402 chr6:127711932 C/A cg24812749 chr6:127587940 RNF146 0.49 7.16 0.36 5.1e-12 Breast cancer; LUSC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg13560548 chr3:10150139 C3orf24 0.47 6.6 0.34 1.58e-10 Alzheimer's disease; LUSC cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg12935359 chr14:103987150 CKB -0.52 -8.07 -0.4 1.26e-14 Body mass index; LUSC cis rs6076065 0.510 rs6137899 chr20:23320137 C/T cg11657817 chr20:23433608 CST11 0.4 7.4 0.38 1.13e-12 Facial morphology (factor 15, philtrum width); LUSC cis rs739401 0.572 rs389128 chr11:3083873 G/T cg25174290 chr11:3078921 CARS 0.61 9.53 0.46 3.47e-19 Longevity; LUSC cis rs9837602 1.000 rs4571265 chr3:99705111 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 5.89 0.31 9.26e-9 Breast cancer; LUSC trans rs61931739 0.793 rs609886 chr12:34138160 T/G cg13010199 chr12:38710504 ALG10B 0.43 6.71 0.34 8.6e-11 Morning vs. evening chronotype; LUSC cis rs4654899 0.931 rs3125161 chr1:21126346 A/G cg01072550 chr1:21505969 NA 0.48 7.14 0.36 5.69e-12 Superior frontal gyrus grey matter volume; LUSC cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg26384229 chr12:38710491 ALG10B 0.93 15.97 0.66 4.9e-43 Morning vs. evening chronotype; LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.96 -0.48 1.22e-20 Platelet count; LUSC cis rs7267979 1.000 rs6115168 chr20:25372891 C/A cg03522245 chr20:25566470 NINL -0.35 -5.67 -0.3 3.1e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9300255 0.544 rs1716175 chr12:123658388 A/T cg05973401 chr12:123451056 ABCB9 0.53 6.49 0.33 3.01e-10 Neutrophil percentage of white cells; LUSC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg04155289 chr7:94953770 PON1 -0.34 -5.7 -0.3 2.6e-8 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg03676636 chr4:99064102 C4orf37 0.35 7.65 0.39 2.21e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs17253792 0.822 rs9323289 chr14:56106784 G/C cg01858014 chr14:56050164 KTN1 -0.84 -6.78 -0.35 5.6e-11 Putamen volume; LUSC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg01802117 chr1:53393560 SCP2 0.46 7.46 0.38 7.38e-13 Monocyte count; LUSC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.54 -0.38 4.58e-13 HDL cholesterol;Metabolic syndrome; LUSC cis rs9790314 1.000 rs336548 chr3:161058412 T/C cg03342759 chr3:160939853 NMD3 -0.49 -8.18 -0.41 5.82e-15 Morning vs. evening chronotype; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg17680823 chr2:240016541 HDAC4 -0.39 -6.21 -0.32 1.55e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC trans rs3857536 0.740 rs4710572 chr6:66890361 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.46 -6.41 -0.33 4.96e-10 Blood trace element (Cu levels); LUSC trans rs2262909 1.000 rs2175366 chr19:22128279 C/T cg05197062 chr11:11642011 GALNTL4 -0.51 -7.02 -0.36 1.27e-11 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg05313129 chr8:58192883 C8orf71 -0.5 -5.71 -0.3 2.44e-8 Developmental language disorder (linguistic errors); LUSC trans rs3824488 0.920 rs28510415 chr9:98245026 A/G cg23555120 chr12:106533863 NUAK1 0.57 6.19 0.32 1.81e-9 Neuroticism; LUSC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg20607287 chr7:12443886 VWDE -0.6 -6.26 -0.32 1.2e-9 Coronary artery disease; LUSC cis rs11039100 0.607 rs11038952 chr11:5780354 T/C cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg26314531 chr2:26401878 FAM59B -0.66 -9.13 -0.45 6.46e-18 Gut microbiome composition (summer); LUSC cis rs11018904 0.906 rs55685917 chr11:89964365 T/C cg26138821 chr11:89956704 CHORDC1 -0.58 -7.18 -0.37 4.67e-12 Intelligence (multi-trait analysis); LUSC cis rs4478858 0.735 rs4949205 chr1:31800579 A/G cg00250761 chr1:31883323 NA -0.36 -8.94 -0.44 2.66e-17 Alcohol dependence; LUSC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg14552801 chr7:65878734 NA -0.46 -6.53 -0.34 2.45e-10 Aortic root size; LUSC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg01842473 chr11:617407 IRF7;MUPCDH -0.6 -8.18 -0.41 6.14e-15 Systemic lupus erythematosus; LUSC cis rs7829975 0.535 rs4841005 chr8:8501230 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.38 -0.33 5.83e-10 Mood instability; LUSC trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg20111118 chr4:148653624 ARHGAP10 0.39 6.32 0.33 8.51e-10 Mosquito bite size; LUSC cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg13010199 chr12:38710504 ALG10B 0.65 10.16 0.49 2.61e-21 Bladder cancer; LUSC cis rs9790314 1.000 rs1993891 chr3:161047467 A/G cg04691961 chr3:161091175 C3orf57 -0.35 -6.11 -0.32 2.74e-9 Morning vs. evening chronotype; LUSC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg14893161 chr1:205819251 PM20D1 0.42 5.77 0.3 1.85e-8 Parkinson's disease; LUSC cis rs11122272 0.735 rs2486730 chr1:231534987 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.0 -0.48 9.09e-21 Hemoglobin concentration; LUSC cis rs9549367 0.712 rs2316443 chr13:113864837 G/A cg18105134 chr13:113819100 PROZ -0.68 -10.19 -0.49 1.99e-21 Platelet distribution width; LUSC cis rs6701037 0.748 rs10912901 chr1:175138602 G/A cg00321850 chr1:175162397 KIAA0040 -0.46 -7.94 -0.4 3.19e-14 Alcohol dependence; LUSC trans rs7618501 0.602 rs2624816 chr3:50117312 T/G cg21659725 chr3:3221576 CRBN -0.64 -10.41 -0.49 3.65e-22 Intelligence (multi-trait analysis); LUSC trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg03929089 chr4:120376271 NA 0.61 6.59 0.34 1.71e-10 Axial length; LUSC trans rs10028773 0.700 rs7690338 chr4:120256468 C/G cg25214090 chr10:38739885 LOC399744 0.42 6.43 0.33 4.34e-10 Educational attainment; LUSC cis rs7091068 0.662 rs829106 chr10:95441742 G/T cg20715218 chr10:95462985 C10orf4 0.64 6.89 0.35 2.75e-11 Urinary tract infection frequency; LUSC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg11189052 chr15:85197271 WDR73 -0.63 -9.89 -0.48 2.09e-20 P wave terminal force; LUSC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.69 -0.3 2.85e-8 Depression; LUSC cis rs34734847 1.000 rs34734847 chr12:121154221 T/C cg27246729 chr12:121163418 ACADS 0.47 7.52 0.38 4.94e-13 Mean corpuscular volume; LUSC cis rs7527798 0.592 rs12411037 chr1:207857158 T/C cg09232269 chr1:207846808 CR1L -0.32 -6.87 -0.35 3.21e-11 Erythrocyte sedimentation rate; LUSC cis rs477692 0.663 rs491929 chr10:131368111 G/A cg05714579 chr10:131428358 MGMT 0.46 6.42 0.33 4.64e-10 Response to temozolomide; LUSC cis rs911555 0.723 rs6575991 chr14:103908433 C/T cg24130564 chr14:104152367 KLC1 0.45 6.53 0.34 2.43e-10 Intelligence (multi-trait analysis); LUSC cis rs459571 0.920 rs433402 chr9:136898627 A/G cg13789015 chr9:136890014 NCRNA00094 0.7 12.41 0.56 2.52e-29 Platelet distribution width; LUSC cis rs55728055 0.661 rs12165609 chr22:32036332 T/C cg01338084 chr22:32026380 PISD 0.82 6.18 0.32 1.83e-9 Age-related hearing impairment; LUSC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg00033643 chr7:134001901 SLC35B4 0.46 7.25 0.37 3e-12 Mean platelet volume; LUSC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -8.56 -0.42 4.27e-16 Bipolar disorder and schizophrenia; LUSC cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.44 -6.51 -0.34 2.81e-10 Educational attainment; LUSC cis rs2969070 0.763 rs4721714 chr7:2498467 G/A cg03277898 chr7:2518824 NA -0.29 -6.06 -0.31 3.77e-9 Diastolic blood pressure; LUSC cis rs7267979 0.966 rs2261790 chr20:25262789 T/C cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.56e-11 Liver enzyme levels (alkaline phosphatase); LUSC trans rs979233 0.502 rs2202093 chr5:42130945 T/A cg07010552 chr17:7358735 CHRNB1 -0.42 -6.09 -0.32 3.15e-9 Systemic lupus erythematosus; LUSC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg23978390 chr7:1156363 C7orf50 0.48 5.84 0.3 1.23e-8 Bronchopulmonary dysplasia; LUSC cis rs672059 1.000 rs672119 chr1:183162506 G/A ch.1.3577855R chr1:183094577 LAMC1 0.55 8.1 0.41 1.02e-14 Hypertriglyceridemia; LUSC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg13206674 chr6:150067644 NUP43 0.44 6.72 0.35 7.64e-11 Testicular germ cell tumor; LUSC cis rs59698941 0.943 rs67551921 chr5:132289033 G/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs2859741 0.967 rs507460 chr1:37493206 C/G cg09363841 chr1:37513479 NA 0.36 7.1 0.36 7.73e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); LUSC cis rs9880211 0.898 rs6770476 chr3:136073920 C/T cg21827317 chr3:136751795 NA -0.39 -6.1 -0.32 2.9e-9 Body mass index;Height; LUSC cis rs6964587 1.000 rs1859113 chr7:91679887 T/C cg22709100 chr7:91322751 NA 0.39 5.79 0.3 1.67e-8 Breast cancer; LUSC cis rs6669919 0.901 rs7527396 chr1:211667857 C/T cg25617285 chr1:211431773 RCOR3 -0.36 -6.03 -0.31 4.26e-9 Intelligence (multi-trait analysis); LUSC cis rs7590368 1.000 rs2884289 chr2:10959724 G/A cg15705551 chr2:10952987 PDIA6 0.58 8.0 0.4 2.11e-14 Educational attainment (years of education); LUSC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.97 -0.31 6.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17818399 0.510 rs12105801 chr2:46799343 C/G cg02822958 chr2:46747628 ATP6V1E2 0.41 6.75 0.35 6.53e-11 Height; LUSC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg18402987 chr7:1209562 NA 0.67 7.1 0.36 7.4e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs9486719 1.000 rs11153067 chr6:97039421 A/T cg06623918 chr6:96969491 KIAA0776 0.8 10.38 0.49 4.79e-22 Migraine;Coronary artery disease; LUSC trans rs634534 0.622 rs1192168 chr11:65730945 T/G cg17712092 chr4:129076599 LARP1B 0.74 11.21 0.52 5.88e-25 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg06740227 chr12:86229804 RASSF9 0.37 5.79 0.3 1.59e-8 Major depressive disorder; LUSC cis rs2346177 0.554 rs34854267 chr2:46708542 T/C cg02822958 chr2:46747628 ATP6V1E2 0.47 8.3 0.41 2.68e-15 HDL cholesterol; LUSC cis rs4319547 0.656 rs7135419 chr12:122911861 T/A cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.4 -0.42 1.3e-15 Body mass index; LUSC cis rs9815354 0.638 rs73073267 chr3:42021163 A/T cg03022575 chr3:42003672 ULK4 0.77 7.77 0.39 9.53e-14 Pulse pressure;Diastolic blood pressure; LUSC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg12463550 chr7:65579703 CRCP -0.53 -7.73 -0.39 1.24e-13 Aortic root size; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg21137026 chr11:417246 SIGIRR 0.42 6.77 0.35 5.74e-11 Schizophrenia; LUSC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg24562669 chr7:97807699 LMTK2 0.35 6.16 0.32 2.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs500891 0.693 rs1145914 chr6:83993797 A/G cg08257003 chr6:84140564 ME1 0.33 7.15 0.36 5.67e-12 Platelet-derived growth factor BB levels; LUSC cis rs7246657 0.882 rs6508716 chr19:37819010 T/C cg23950597 chr19:37808831 NA -0.65 -7.91 -0.4 3.9e-14 Coronary artery calcification; LUSC cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.4 0.49 3.97e-22 Schizophrenia; LUSC cis rs35079168 0.923 rs10858277 chr9:137287959 G/A cg13941235 chr9:137270186 RXRA -0.32 -5.7 -0.3 2.66e-8 Intelligence; LUSC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg11062466 chr8:58055876 NA 0.67 8.68 0.43 1.72e-16 Developmental language disorder (linguistic errors); LUSC cis rs9346649 0.933 rs9364398 chr6:168489433 G/T cg02770688 chr6:168491649 NA -0.38 -6.99 -0.36 1.52e-11 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; LUSC cis rs10886558 0.662 rs2151888 chr10:121769435 G/T cg02041677 chr10:121771263 NA 0.34 5.73 0.3 2.23e-8 Shingles; LUSC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.52 0.38 5.18e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg13047869 chr3:10149882 C3orf24 0.56 7.73 0.39 1.24e-13 Alzheimer's disease; LUSC cis rs983392 0.805 rs2123314 chr11:59966295 C/T cg02771260 chr11:59836817 MS4A3 0.36 5.98 0.31 5.8e-9 Alzheimer's disease (late onset); LUSC cis rs4499344 0.604 rs259287 chr19:33164859 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.76 11.73 0.54 7.5e-27 Mean platelet volume; LUSC cis rs7432375 0.610 rs7621932 chr3:136517016 C/T cg15507776 chr3:136538369 TMEM22 0.44 7.34 0.37 1.68e-12 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs686320 1.000 rs1787666 chr11:65249089 A/C cg21890820 chr11:65308645 LTBP3 0.75 7.64 0.39 2.29e-13 Hip circumference adjusted for BMI; LUSC cis rs3820068 0.705 rs4646110 chr1:15817318 A/T cg17385448 chr1:15911702 AGMAT 0.4 6.05 0.31 3.94e-9 Systolic blood pressure; LUSC cis rs12410462 0.681 rs58496521 chr1:227582375 T/C cg04117972 chr1:227635322 NA 0.61 6.73 0.35 7.22e-11 Major depressive disorder; LUSC cis rs7193541 0.646 rs7188880 chr16:74664810 A/T cg01733217 chr16:74700730 RFWD3 0.98 21.95 0.77 9.95e-67 Multiple myeloma; LUSC trans rs4843747 0.636 rs4075597 chr16:88107590 C/A cg26811252 chr16:29126840 RRN3P2 0.58 9.17 0.45 5.08e-18 Menopause (age at onset); LUSC cis rs17095355 1.000 rs7080576 chr10:111710817 C/T cg00817464 chr10:111662876 XPNPEP1 0.58 7.58 0.38 3.46e-13 Biliary atresia; LUSC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg14552801 chr7:65878734 NA -0.38 -5.96 -0.31 6.31e-9 Aortic root size; LUSC cis rs13385 0.769 rs4913074 chr5:139613567 T/C cg26211634 chr5:139558579 C5orf32 0.46 7.05 0.36 1.04e-11 Atrial fibrillation; LUSC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 6.4 0.33 5.13e-10 Electroencephalogram traits; LUSC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 11.62 0.54 2e-26 Alzheimer's disease; LUSC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg23978390 chr7:1156363 C7orf50 0.49 6.76 0.35 6.34e-11 Longevity;Endometriosis; LUSC cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg03146154 chr1:46216737 IPP 0.5 7.36 0.37 1.42e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6700896 0.931 rs12044840 chr1:66115213 C/G cg04111102 chr1:66153794 NA 0.32 7.1 0.36 7.54e-12 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg27432699 chr2:27873401 GPN1 -0.56 -8.39 -0.42 1.4e-15 Total body bone mineral density; LUSC cis rs9815354 1.000 rs6768128 chr3:41865080 G/A cg03022575 chr3:42003672 ULK4 0.59 6.55 0.34 2.2e-10 Pulse pressure;Diastolic blood pressure; LUSC cis rs231513 0.954 rs231508 chr17:41967583 G/A cg26893861 chr17:41843967 DUSP3 -0.52 -6.23 -0.32 1.37e-9 Cognitive function; LUSC cis rs1371867 0.875 rs1612773 chr8:101337818 G/C cg06636551 chr8:101224915 SPAG1 -0.39 -7.13 -0.36 6.17e-12 Atrioventricular conduction; LUSC cis rs68170813 0.596 rs76888321 chr7:106945926 T/C cg02696742 chr7:106810147 HBP1 -0.64 -9.87 -0.48 2.57e-20 Coronary artery disease; LUSC cis rs970548 0.688 rs2082111 chr10:45931060 A/C cg15590007 chr10:45870220 ALOX5 0.58 6.57 0.34 1.92e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; LUSC cis rs8014204 0.905 rs8014289 chr14:75377352 A/G cg08847533 chr14:75593920 NEK9 -0.39 -5.87 -0.31 1.07e-8 Caffeine consumption; LUSC cis rs860295 0.580 rs7528441 chr1:155843256 T/G cg08949192 chr1:155289623 RUSC1;FDPS -0.34 -5.67 -0.3 3.07e-8 Body mass index; LUSC cis rs2463822 1.000 rs7481995 chr11:62129312 G/C cg06239285 chr11:62104954 ASRGL1 0.98 10.97 0.51 4.05e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs500891 0.533 rs1932092 chr6:84192944 G/A cg08257003 chr6:84140564 ME1 -0.33 -8.03 -0.4 1.67e-14 Platelet-derived growth factor BB levels; LUSC cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.92 -0.35 2.38e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg15691649 chr6:25882328 NA -0.41 -5.96 -0.31 6.28e-9 Intelligence (multi-trait analysis); LUSC cis rs7208859 0.573 rs60724269 chr17:29113273 G/T cg13385521 chr17:29058706 SUZ12P 0.68 6.67 0.34 1.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs7945718 0.934 rs10831909 chr11:12817182 C/G cg25843174 chr11:12811716 TEAD1 0.33 7.21 0.37 3.75e-12 Educational attainment (years of education); LUSC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg09365446 chr1:150670422 GOLPH3L -0.46 -6.99 -0.36 1.48e-11 Melanoma; LUSC cis rs7617480 0.648 rs6796790 chr3:48780317 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.65 9.96 0.48 1.2e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg14343924 chr8:8086146 FLJ10661 0.41 5.69 0.3 2.82e-8 Mood instability; LUSC cis rs2637266 0.783 rs846640 chr10:78524293 T/C cg18941641 chr10:78392320 NA 0.39 7.12 0.36 6.86e-12 Pulmonary function; LUSC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg00343986 chr7:65444356 GUSB 0.43 6.54 0.34 2.29e-10 Aortic root size; LUSC cis rs4631830 0.900 rs10763534 chr10:51534920 C/T cg16070123 chr10:51489643 NA -0.52 -8.22 -0.41 4.48e-15 Prostate-specific antigen levels; LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg25703541 chr22:24373054 LOC391322 -0.89 -14.49 -0.62 2.87e-37 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg14893161 chr1:205819251 PM20D1 0.42 5.74 0.3 2.09e-8 Parkinson's disease; LUSC cis rs10979 0.782 rs9390108 chr6:143892722 A/T cg25407410 chr6:143891975 LOC285740 -0.73 -11.58 -0.54 2.64e-26 Hypospadias; LUSC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg06740227 chr12:86229804 RASSF9 0.36 5.75 0.3 2.04e-8 Major depressive disorder; LUSC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg25019033 chr10:957182 NA -0.53 -6.9 -0.35 2.61e-11 Eosinophil percentage of granulocytes; LUSC trans rs3960554 0.808 rs11983987 chr7:75657850 A/G cg19862616 chr7:65841803 NCRNA00174 0.66 7.59 0.38 3.15e-13 Eotaxin levels; LUSC cis rs6430585 0.583 rs4988145 chr2:136632300 A/C cg07169764 chr2:136633963 MCM6 1.23 18.5 0.71 4.35e-53 Corneal structure; LUSC cis rs506338 0.517 rs530775 chr11:64426933 A/G cg19131476 chr11:64387923 NRXN2 0.36 7.81 0.39 7.34e-14 Body mass index;Urate levels; LUSC cis rs9527 0.640 rs35195396 chr10:104928770 T/A cg05855489 chr10:104503620 C10orf26 0.52 7.88 0.4 4.72e-14 Arsenic metabolism; LUSC cis rs7945705 0.738 rs11042067 chr11:8815453 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -9.87 -0.48 2.48e-20 Hemoglobin concentration; LUSC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg19592336 chr6:28129416 ZNF389 0.53 7.23 0.37 3.25e-12 Depression; LUSC trans rs853679 0.607 rs13197574 chr6:28060239 T/C cg06606381 chr12:133084897 FBRSL1 -1.05 -9.22 -0.45 3.34e-18 Depression; LUSC cis rs7954584 0.504 rs10840633 chr12:122377511 A/T cg13699009 chr12:122356056 WDR66 0.5 7.46 0.38 7.33e-13 Mean corpuscular volume; LUSC cis rs3812111 0.510 rs9387390 chr6:116584080 T/C cg18828861 chr6:116576566 TSPYL4 0.38 6.74 0.35 7e-11 Age-related macular degeneration; LUSC cis rs7824557 0.767 rs10104728 chr8:11171300 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.23 0.32 1.37e-9 Retinal vascular caliber; LUSC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 14.21 0.61 3.51e-36 Platelet count; LUSC cis rs2502731 0.539 rs3003608 chr9:130984430 C/A cg13642260 chr9:130955380 CIZ1 0.44 6.97 0.36 1.75e-11 Attention deficit hyperactivity disorder; LUSC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.5 9.51 0.46 4.02e-19 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg25258033 chr6:167368657 RNASET2 0.47 7.75 0.39 1.11e-13 Crohn's disease; LUSC cis rs77741769 0.764 rs11065332 chr12:121360959 G/A cg02403541 chr12:121454288 C12orf43 0.51 7.54 0.38 4.58e-13 Mean corpuscular volume; LUSC cis rs10465746 0.780 rs11163865 chr1:84366917 C/T cg10977910 chr1:84465055 TTLL7 0.45 6.36 0.33 6.7e-10 Obesity-related traits; LUSC trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg13615516 chr5:77269221 NA 0.39 6.68 0.34 9.78e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs61931739 0.534 rs1912773 chr12:34097401 T/C cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg04414720 chr1:150670196 GOLPH3L -0.48 -7.21 -0.37 3.65e-12 Urate levels; LUSC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg07701084 chr6:150067640 NUP43 0.57 8.88 0.44 4.29e-17 Lung cancer; LUSC cis rs2739330 0.796 rs5760097 chr22:24247794 G/C cg11060661 chr22:24314208 DDT;DDTL 0.49 8.05 0.4 1.47e-14 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.91 -0.35 2.4e-11 Menopause (age at onset); LUSC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg18876405 chr7:65276391 NA 0.55 8.77 0.43 9.27e-17 Aortic root size; LUSC cis rs11105298 0.838 rs10858862 chr12:89842053 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -7.36 -0.37 1.4e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs1949733 1.000 rs6447875 chr4:8503206 T/C cg13073564 chr4:8508604 NA -0.49 -9.22 -0.45 3.38e-18 Response to antineoplastic agents; LUSC cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.67 0.39 1.89e-13 Intelligence (multi-trait analysis); LUSC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg25767906 chr1:53392781 SCP2 0.48 8.71 0.43 1.47e-16 Monocyte count; LUSC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg22535103 chr8:58192502 C8orf71 -0.65 -7.34 -0.37 1.59e-12 Developmental language disorder (linguistic errors); LUSC trans rs9291683 0.588 rs3756236 chr4:10013463 T/A cg26043149 chr18:55253948 FECH 0.49 7.28 0.37 2.43e-12 Bone mineral density; LUSC cis rs6062509 0.732 rs6062304 chr20:62351539 A/T cg01176363 chr20:62369445 LIME1 -0.46 -6.98 -0.36 1.63e-11 Prostate cancer; LUSC cis rs1371867 0.846 rs1788199 chr8:101292854 A/G cg00191853 chr8:101177733 SPAG1 -0.41 -6.56 -0.34 2.08e-10 Atrioventricular conduction; LUSC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg08499158 chr17:42289980 UBTF -0.52 -8.65 -0.43 2.18e-16 Total body bone mineral density; LUSC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg21724239 chr8:58056113 NA 0.73 8.03 0.4 1.73e-14 Developmental language disorder (linguistic errors); LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg16606324 chr3:10149918 C3orf24 0.66 9.6 0.47 1.97e-19 Alzheimer's disease; LUSC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg11764359 chr7:65958608 NA -0.69 -10.49 -0.5 1.88e-22 Aortic root size; LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg06873352 chr17:61820015 STRADA 0.73 13.13 0.58 4.77e-32 Prudent dietary pattern; LUSC cis rs7264396 0.778 rs6120959 chr20:34077848 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.41 -0.33 5.1e-10 Total cholesterol levels; LUSC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg25067162 chr17:41277974 BRCA1;NBR2 0.37 6.25 0.32 1.28e-9 Menopause (age at onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg17890984 chr13:95248455 TGDS -0.42 -6.23 -0.32 1.43e-9 Electrocardiographic conduction measures; LUSC cis rs11077998 0.933 rs2291395 chr17:80526139 A/G cg10255544 chr17:80519551 FOXK2 0.36 5.8 0.3 1.51e-8 Reticulocyte fraction of red cells; LUSC cis rs4631830 0.932 rs4581397 chr10:51532367 A/G cg10326726 chr10:51549505 MSMB -0.34 -5.76 -0.3 1.86e-8 Prostate-specific antigen levels; LUSC cis rs2303282 0.665 rs922446 chr16:56393191 T/C cg00500540 chr16:56394104 NA -0.44 -7.52 -0.38 5.12e-13 Breast cancer; LUSC trans rs61931739 0.500 rs11053282 chr12:34561151 T/C cg26384229 chr12:38710491 ALG10B 0.9 15.54 0.65 2.33e-41 Morning vs. evening chronotype; LUSC cis rs765787 0.530 rs11854690 chr15:45516016 C/T cg24006582 chr15:45444508 DUOX1 -0.61 -8.95 -0.44 2.44e-17 Uric acid levels; LUSC cis rs2398893 0.889 rs7872984 chr9:96782447 T/C cg14459158 chr9:96720562 NA 0.3 5.9 0.31 8.96e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.24 0.56 1.01e-28 Motion sickness; LUSC trans rs17039065 0.920 rs12506757 chr4:109411903 G/A cg07444054 chr2:108107501 NA 0.45 6.29 0.33 1.01e-9 Gut microbiome composition (summer); LUSC trans rs7829975 0.514 rs2920991 chr8:8259117 T/A cg21775007 chr8:11205619 TDH 0.42 6.18 0.32 1.9e-9 Mood instability; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07333738 chr16:765560 METRN -0.51 -6.32 -0.33 8.48e-10 Bipolar disorder and schizophrenia; LUSC cis rs59918340 0.764 rs9324542 chr8:142227854 A/T cg23750338 chr8:142222470 SLC45A4 -0.52 -10.02 -0.48 7.63e-21 Immature fraction of reticulocytes; LUSC cis rs9462027 0.628 rs6919654 chr6:34810739 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.75 -0.3 1.97e-8 Systemic lupus erythematosus; LUSC cis rs4690686 0.534 rs11133147 chr4:177281718 A/G cg17059388 chr4:177262070 NA 0.32 6.43 0.33 4.46e-10 Essential tremor; LUSC cis rs10992471 0.603 rs13301537 chr9:95229047 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.45 -7.68 -0.39 1.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs58688157 0.921 rs12805435 chr11:612355 T/C cg05717871 chr11:638507 DRD4 -0.34 -5.9 -0.31 8.74e-9 Systemic lupus erythematosus; LUSC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 0.37 6.95 0.36 1.97e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs7759001 0.857 rs9468101 chr6:27352938 G/A cg18711553 chr6:27366782 ZNF391 0.39 5.75 0.3 1.97e-8 Glomerular filtration rate (creatinine); LUSC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg09044154 chr16:88155775 NA -0.59 -7.85 -0.39 5.6e-14 Menopause (age at onset); LUSC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg09699651 chr6:150184138 LRP11 0.37 5.86 0.31 1.12e-8 Lung cancer; LUSC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg14159672 chr1:205819179 PM20D1 0.98 21.18 0.76 9.77e-64 Menarche (age at onset); LUSC cis rs3741151 1.000 rs75004180 chr11:73024739 A/G cg17517138 chr11:73019481 ARHGEF17 1.09 9.25 0.45 2.82e-18 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7681440 0.647 rs1372508 chr4:90819786 C/G cg01966878 chr4:90757139 SNCA 0.34 5.72 0.3 2.34e-8 Dementia with Lewy bodies; LUSC cis rs13089785 1.000 rs35181974 chr3:123607884 C/A cg19611163 chr3:123411211 MYLK 0.34 5.84 0.3 1.23e-8 Intelligence (multi-trait analysis); LUSC cis rs62400317 0.859 rs12203558 chr6:45244423 C/G cg20913747 chr6:44695427 NA -0.47 -7.65 -0.39 2.2e-13 Total body bone mineral density; LUSC cis rs9325144 0.647 rs7487395 chr12:38865660 C/A cg26384229 chr12:38710491 ALG10B -0.6 -9.23 -0.45 3.26e-18 Morning vs. evening chronotype; LUSC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC trans rs3733585 0.783 rs13148371 chr4:10032561 C/T cg26043149 chr18:55253948 FECH 0.51 7.52 0.38 4.96e-13 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs34311866 0.808 rs11728344 chr4:963755 T/C cg07828340 chr4:882639 GAK 0.97 9.67 0.47 1.14e-19 Parkinson's disease; LUSC cis rs7945705 0.846 rs4929911 chr11:8816495 T/C cg12365402 chr11:9010492 NRIP3 0.47 8.39 0.42 1.39e-15 Hemoglobin concentration; LUSC trans rs61931739 0.500 rs11053212 chr12:34466116 T/G cg13010199 chr12:38710504 ALG10B 0.68 10.77 0.51 1.98e-23 Morning vs. evening chronotype; LUSC cis rs9815354 0.812 rs73071352 chr3:41828300 A/G cg03022575 chr3:42003672 ULK4 0.85 8.62 0.43 2.78e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg26395211 chr5:140044315 WDR55 0.45 7.01 0.36 1.33e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg06873352 chr17:61820015 STRADA 0.72 12.79 0.57 9.24e-31 Prudent dietary pattern; LUSC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg00857998 chr1:205179979 DSTYK 0.63 9.64 0.47 1.41e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4363385 0.818 rs1890285 chr1:153015396 T/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.53 -0.38 4.68e-13 Inflammatory skin disease; LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.61 0.43 2.84e-16 Prudent dietary pattern; LUSC cis rs2204008 0.570 rs1315664 chr12:38138274 A/G cg26384229 chr12:38710491 ALG10B -0.66 -10.14 -0.49 3.06e-21 Bladder cancer; LUSC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg07837209 chr13:79184101 NA -0.5 -7.1 -0.36 7.7e-12 Large artery stroke; LUSC trans rs4843747 0.671 rs28465438 chr16:88103714 G/A cg26811252 chr16:29126840 RRN3P2 0.61 9.7 0.47 9.3e-20 Menopause (age at onset); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg06375580 chr12:42538820 GXYLT1 0.42 6.0 0.31 5e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg13010199 chr12:38710504 ALG10B 0.69 10.65 0.5 5.27e-23 Bladder cancer; LUSC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg22823121 chr1:150693482 HORMAD1 0.6 9.33 0.45 1.46e-18 Tonsillectomy; LUSC cis rs1372520 0.577 rs748849 chr4:90734961 G/A cg14346243 chr4:90757452 SNCA -0.39 -5.73 -0.3 2.25e-8 Neuroticism; LUSC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg13397359 chr6:42928475 GNMT 0.65 11.1 0.52 1.37e-24 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs3790645 1.000 rs1064196 chr1:26887592 C/T cg17456097 chr1:26900765 RPS6KA1 -0.41 -5.89 -0.31 9.19e-9 Glucose homeostasis traits; LUSC trans rs9329221 0.662 rs13254942 chr8:10257678 C/T cg15556689 chr8:8085844 FLJ10661 -0.52 -7.53 -0.38 4.91e-13 Neuroticism; LUSC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg18758796 chr5:131593413 PDLIM4 0.43 7.35 0.37 1.54e-12 Breast cancer; LUSC cis rs9303542 0.527 rs8074125 chr17:46610060 G/T cg09704116 chr17:46666958 LOC404266 -0.37 -6.52 -0.34 2.56e-10 Ovarian cancer;Epithelial ovarian cancer; LUSC cis rs709400 0.567 rs11624343 chr14:103859156 T/A cg12935359 chr14:103987150 CKB -0.53 -8.13 -0.41 8.59e-15 Body mass index; LUSC trans rs7980799 0.711 rs1482993 chr12:33594515 G/A cg26384229 chr12:38710491 ALG10B -0.59 -8.96 -0.44 2.32e-17 Heart rate;Heart rate variability traits (RMSSD); LUSC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg12963246 chr6:28129442 ZNF389 0.54 7.74 0.39 1.2e-13 Parkinson's disease; LUSC cis rs1712517 0.844 rs1163087 chr10:105043289 G/A cg05636881 chr10:105038444 INA 0.39 6.3 0.33 9.24e-10 Migraine; LUSC cis rs9650657 0.644 rs10091386 chr8:10696620 A/C cg27411982 chr8:10470053 RP1L1 -0.39 -6.36 -0.33 6.49e-10 Neuroticism; LUSC cis rs1375194 0.582 rs4670735 chr2:33801456 C/T cg04131969 chr2:33951647 MYADML -0.65 -9.01 -0.44 1.66e-17 Response to antidepressants in depression; LUSC cis rs10207060 0.500 rs7566489 chr2:240703985 C/T cg20333904 chr2:240724165 NA -0.35 -6.1 -0.32 2.95e-9 Obesity-related traits; LUSC cis rs6460942 0.908 rs6978768 chr7:12232366 G/A cg06484146 chr7:12443880 VWDE -0.56 -5.75 -0.3 2.03e-8 Coronary artery disease; LUSC trans rs10208649 1.000 rs6731217 chr2:54131093 A/G cg07564088 chr5:95170684 NA 0.68 5.97 0.31 6.17e-9 Body mass index; LUSC cis rs7000551 0.751 rs2469768 chr8:22381362 G/A cg12081754 chr8:22256438 SLC39A14 0.47 7.24 0.37 3.2e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; LUSC cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg24642439 chr20:33292090 TP53INP2 0.5 7.43 0.38 8.94e-13 Height; LUSC cis rs11155671 0.530 rs3823021 chr6:150210999 G/C cg07701084 chr6:150067640 NUP43 0.46 6.93 0.35 2.23e-11 Testicular germ cell tumor; LUSC cis rs12824058 0.816 rs1874522 chr12:130816536 C/T cg24838063 chr12:130822603 PIWIL1 -0.67 -10.75 -0.51 2.43e-23 Menopause (age at onset); LUSC cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg01765077 chr12:122356316 WDR66 0.51 7.38 0.37 1.25e-12 Mean corpuscular volume; LUSC trans rs1493916 1.000 rs4799729 chr18:31393521 C/T cg27147174 chr7:100797783 AP1S1 0.63 9.62 0.47 1.64e-19 Life satisfaction; LUSC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.56 0.5 1.12e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs13126513 0.510 rs10516445 chr4:100524679 C/G cg05468953 chr4:100565104 NA 0.38 7.22 0.37 3.52e-12 Metabolite levels (MHPG); LUSC trans rs16993852 1.000 rs112708439 chr4:37753497 C/A cg10635443 chr8:23557486 NA 0.53 6.09 0.32 3.05e-9 Staphylococcus aureus nasal carriage (intermittent); LUSC cis rs11148252 0.595 rs9526968 chr13:53240183 T/C cg02158880 chr13:53174818 NA 0.55 9.35 0.46 1.28e-18 Lewy body disease; LUSC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg16405210 chr4:1374714 KIAA1530 -0.55 -8.3 -0.41 2.63e-15 Obesity-related traits; LUSC cis rs500891 1.000 rs17256973 chr6:84175967 C/T cg08257003 chr6:84140564 ME1 0.34 7.12 0.36 6.55e-12 Platelet-derived growth factor BB levels; LUSC cis rs6545883 0.525 rs1729662 chr2:61391305 G/A cg15711740 chr2:61764176 XPO1 -0.41 -6.43 -0.33 4.54e-10 Tuberculosis; LUSC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 8.78e-9 Lung cancer; LUSC cis rs1801251 0.778 rs2675957 chr2:233754364 C/T cg25237894 chr2:233734115 C2orf82 -0.37 -6.91 -0.35 2.41e-11 Coronary artery disease; LUSC cis rs11785400 0.793 rs11785376 chr8:143730412 C/T cg10596483 chr8:143751796 JRK 0.53 7.59 0.38 3.17e-13 Schizophrenia; LUSC cis rs11997175 0.583 rs56045827 chr8:33787015 G/A ch.8.33884649F chr8:33765107 NA 0.46 6.76 0.35 6.32e-11 Body mass index; LUSC cis rs1832871 0.672 rs6933928 chr6:158747071 C/T cg07165851 chr6:158734300 TULP4 0.46 6.89 0.35 2.81e-11 Height; LUSC cis rs6840360 0.642 rs11735957 chr4:152427506 G/A cg20465933 chr4:152376761 FAM160A1 0.33 5.94 0.31 7.18e-9 Intelligence (multi-trait analysis); LUSC cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg00745463 chr17:30367425 LRRC37B 0.88 8.73 0.43 1.21e-16 Hip circumference adjusted for BMI; LUSC trans rs7944735 0.832 rs7130876 chr11:48050995 A/G cg15704280 chr7:45808275 SEPT13 0.72 7.28 0.37 2.4e-12 Intraocular pressure; LUSC cis rs72781680 1.000 rs12620594 chr2:24194490 G/A cg20701182 chr2:24300061 SF3B14 0.58 6.19 0.32 1.72e-9 Lymphocyte counts; LUSC cis rs6547741 0.904 rs1528403 chr2:27846645 C/G cg27432699 chr2:27873401 GPN1 0.79 14.36 0.62 9.17e-37 Oral cavity cancer; LUSC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.67 0.3 3.1e-8 Intelligence (multi-trait analysis); LUSC cis rs7523050 0.643 rs12725689 chr1:109405151 T/C cg08274380 chr1:109419600 GPSM2 1.12 10.99 0.52 3.4e-24 Fat distribution (HIV); LUSC cis rs6967385 0.604 rs2883866 chr7:12332245 T/A cg06484146 chr7:12443880 VWDE 0.41 6.54 0.34 2.34e-10 Response to taxane treatment (placlitaxel); LUSC cis rs2797160 0.837 rs1739364 chr6:126022383 A/G cg05901451 chr6:126070800 HEY2 -0.59 -9.09 -0.45 9.25e-18 Endometrial cancer; LUSC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg14552801 chr7:65878734 NA -0.46 -6.47 -0.33 3.44e-10 Aortic root size; LUSC cis rs12477438 0.765 rs7591992 chr2:99668954 A/C cg15544633 chr2:99771531 LIPT1;TSGA10 -0.85 -12.64 -0.57 3.3e-30 Chronic sinus infection; LUSC cis rs9527 0.590 rs7906754 chr10:104782557 T/C cg23093090 chr10:104574429 C10orf26 -0.35 -6.44 -0.33 4.15e-10 Arsenic metabolism; LUSC cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -7.5 -0.38 5.97e-13 Personality dimensions; LUSC cis rs7582180 0.629 rs11686842 chr2:100956139 C/T cg08017756 chr2:100939284 LONRF2 -0.47 -8.64 -0.43 2.36e-16 Intelligence (multi-trait analysis); LUSC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11644478 chr21:40555479 PSMG1 0.94 18.56 0.71 2.36e-53 Cognitive function; LUSC cis rs1997103 0.911 rs6945663 chr7:55407011 C/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC trans rs4332037 0.539 rs11763750 chr7:2080114 G/A cg10840412 chr1:235813424 GNG4 0.55 7.14 0.36 5.8e-12 Bipolar disorder; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg14114326 chr11:63381845 PLA2G16 0.49 6.5 0.34 2.95e-10 Hepatitis; LUSC cis rs1062746 0.738 rs2303764 chr16:87377455 C/G cg02258303 chr16:87377426 FBXO31 0.62 10.26 0.49 1.17e-21 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); LUSC cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg22676075 chr6:135203613 NA 0.57 9.0 0.44 1.7e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs11864453 0.647 rs9932062 chr16:72136055 T/C cg16558253 chr16:72132732 DHX38 -0.38 -6.07 -0.32 3.45e-9 Fibrinogen levels; LUSC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg12463550 chr7:65579703 CRCP -0.63 -5.68 -0.3 2.92e-8 Diabetic kidney disease; LUSC cis rs1003719 0.788 rs2835593 chr21:38465873 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.7 11.38 0.53 1.39e-25 Eye color traits; LUSC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg23985595 chr17:80112537 CCDC57 -0.32 -6.15 -0.32 2.16e-9 Life satisfaction; LUSC cis rs1355223 0.583 rs1553757 chr11:34867089 G/A cg11058730 chr11:34937778 PDHX;APIP 0.67 10.84 0.51 1.18e-23 Systemic lupus erythematosus and Systemic sclerosis; LUSC cis rs2795502 1.000 rs2795508 chr10:43353555 G/T cg27426351 chr10:43362370 NA 0.45 6.48 0.33 3.38e-10 Blood protein levels; LUSC cis rs34779708 0.931 rs55724039 chr10:35465397 A/G cg04310649 chr10:35416472 CREM -0.42 -6.43 -0.33 4.45e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs34779708 0.931 rs2505631 chr10:35368385 A/T cg04310649 chr10:35416472 CREM 0.4 6.27 0.32 1.13e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7107174 0.892 rs4945265 chr11:78027458 G/A cg02023728 chr11:77925099 USP35 0.48 6.83 0.35 4.04e-11 Testicular germ cell tumor; LUSC cis rs7246657 1.000 rs8110011 chr19:37745813 G/T cg23950597 chr19:37808831 NA -0.61 -6.99 -0.36 1.53e-11 Coronary artery calcification; LUSC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg17366294 chr4:99064904 C4orf37 0.56 9.96 0.48 1.27e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg08067268 chr2:26466485 HADHB;HADHA -0.55 -8.28 -0.41 3.02e-15 Gut microbiome composition (summer); LUSC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg05738196 chr6:26577821 NA 0.79 15.12 0.64 1.04e-39 Intelligence (multi-trait analysis); LUSC cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs6831352 0.879 rs4699717 chr4:100066137 C/T cg12011299 chr4:100065546 ADH4 -0.72 -10.43 -0.5 3.12e-22 Alcohol dependence; LUSC cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg16339924 chr4:17578868 LAP3 0.55 8.25 0.41 3.68e-15 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs9614461 0.702 rs2294202 chr22:45738327 A/T cg13318129 chr22:45737514 FAM118A 0.57 6.41 0.33 4.95e-10 Tonsillectomy; LUSC cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg05340658 chr4:99064831 C4orf37 0.66 10.86 0.51 9.9899999999999993e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs11229555 0.957 rs10896796 chr11:58394256 A/G cg15696309 chr11:58395628 NA -0.69 -9.27 -0.45 2.43e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; LUSC cis rs7677751 0.806 rs60806423 chr4:55086816 C/T cg17187183 chr4:55093834 PDGFRA 0.38 5.72 0.3 2.31e-8 Corneal astigmatism; LUSC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg24209194 chr3:40518798 ZNF619 0.45 5.92 0.31 7.86e-9 Renal cell carcinoma; LUSC trans rs911555 0.755 rs35233301 chr14:103885291 A/G cg17675199 chr6:35436792 RPL10A -0.43 -6.34 -0.33 7.25e-10 Intelligence (multi-trait analysis); LUSC cis rs7804356 1.000 rs7785689 chr7:26861609 G/A cg03456212 chr7:26904342 SKAP2 -0.52 -6.09 -0.32 3.05e-9 Type 1 diabetes; LUSC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.55 -8.21 -0.41 4.78e-15 Total body bone mineral density; LUSC cis rs1256061 0.624 rs1256046 chr14:64729356 A/C cg21174375 chr14:64681225 SYNE2 0.35 6.26 0.32 1.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg12311346 chr5:56204834 C5orf35 -0.62 -9.55 -0.46 2.95e-19 Coronary artery disease; LUSC trans rs61931739 0.500 rs10772160 chr12:34456848 G/A cg13010199 chr12:38710504 ALG10B 0.58 9.27 0.45 2.37e-18 Morning vs. evening chronotype; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg18479798 chr11:64533623 SF1 0.53 7.4 0.38 1.15e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7647973 0.626 rs7649428 chr3:49868876 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.61 7.16 0.36 5.27e-12 Menarche (age at onset); LUSC cis rs6489882 0.902 rs1981556 chr12:113372961 C/G cg20102336 chr12:113376681 OAS3 -0.42 -6.03 -0.31 4.29e-9 Chronic lymphocytic leukemia; LUSC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11890956 chr21:40555474 PSMG1 -0.91 -16.09 -0.66 1.54e-43 Cognitive function; LUSC cis rs7089973 0.604 rs7904188 chr10:116610271 G/C cg23260525 chr10:116636907 FAM160B1 0.44 9.34 0.46 1.38e-18 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg11530693 chr1:120165357 ZNF697 0.69 10.79 0.51 1.79e-23 Systemic lupus erythematosus; LUSC cis rs12200782 1.000 rs72844496 chr6:26611608 G/A cg11502198 chr6:26597334 ABT1 -0.76 -5.8 -0.3 1.53e-8 Small cell lung carcinoma; LUSC cis rs11579220 1 rs11579220 chr1:205144363 G/T cg00857998 chr1:205179979 DSTYK 0.67 10.37 0.49 4.88e-22 White blood cell count (basophil);Basophil percentage of white cells; LUSC cis rs644799 0.635 rs10831428 chr11:95508404 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.86 13.12 0.58 5.41e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs3768617 0.745 rs4546885 chr1:183025555 C/G ch.1.3577855R chr1:183094577 LAMC1 0.56 8.09 0.4 1.12e-14 Fuchs's corneal dystrophy; LUSC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg26695010 chr11:65641043 EFEMP2 -0.48 -7.24 -0.37 3.07e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs4654899 0.931 rs10799671 chr1:21196764 C/T cg01072550 chr1:21505969 NA 0.48 7.28 0.37 2.41e-12 Superior frontal gyrus grey matter volume; LUSC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 15.05 0.64 1.96e-39 Platelet count; LUSC cis rs977987 0.933 rs1834014 chr16:75501274 G/A cg04384234 chr16:75411784 CFDP1 -0.48 -7.87 -0.4 4.88e-14 Dupuytren's disease; LUSC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg23711669 chr6:146136114 FBXO30 0.87 16.53 0.67 2.75e-45 Lobe attachment (rater-scored or self-reported); LUSC cis rs12286929 0.576 rs2275997 chr11:115100186 A/G cg04055981 chr11:115044050 NA 0.37 6.5 0.34 2.89e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg23711669 chr6:146136114 FBXO30 -0.92 -17.68 -0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs983392 0.679 rs636317 chr11:60019150 C/T cg24026212 chr11:59952134 MS4A6A 0.38 6.68 0.34 1.01e-10 Alzheimer's disease (late onset); LUSC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg04756594 chr16:24857601 SLC5A11 -0.48 -7.02 -0.36 1.25e-11 Intelligence (multi-trait analysis); LUSC cis rs2294693 0.947 rs9369254 chr6:40989408 T/C cg14769373 chr6:40998127 UNC5CL -0.56 -8.17 -0.41 6.51e-15 Gastric cancer;Non-cardia gastric cancer; LUSC trans rs12902680 0.677 rs1821474 chr15:46543718 A/G cg04321580 chr8:143696133 ARC -0.41 -5.96 -0.31 6.39e-9 Neuroticism; LUSC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg13607699 chr17:42295918 UBTF 0.53 8.25 0.41 3.6e-15 Total body bone mineral density; LUSC cis rs4792901 0.722 rs8074904 chr17:41571577 G/A cg22562494 chr17:41607896 ETV4 -0.32 -6.02 -0.31 4.58e-9 Dupuytren's disease; LUSC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg17376030 chr22:41985996 PMM1 -0.48 -6.04 -0.31 4.06e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6489882 0.872 rs7132797 chr12:113375036 A/C cg20102336 chr12:113376681 OAS3 -0.41 -5.95 -0.31 6.85e-9 Chronic lymphocytic leukemia; LUSC cis rs7177699 0.557 rs62011002 chr15:79120578 C/T cg00540400 chr15:79124168 NA 0.45 7.94 0.4 3.17e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 9.98 0.48 1.06e-20 Personality dimensions; LUSC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg26335602 chr6:28129616 ZNF389 0.45 6.24 0.32 1.33e-9 Depression; LUSC cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.72 11.25 0.52 4e-25 Colorectal cancer; LUSC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.61 -0.43 2.94e-16 Developmental language disorder (linguistic errors); LUSC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.63 9.62 0.47 1.65e-19 Height; LUSC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg16405210 chr4:1374714 KIAA1530 -0.56 -9.03 -0.44 1.39e-17 Obesity-related traits; LUSC cis rs11997175 0.679 rs10954935 chr8:33670379 C/G ch.8.33884649F chr8:33765107 NA 0.39 6.03 0.31 4.27e-9 Body mass index; LUSC cis rs977987 0.836 rs7200053 chr16:75474618 C/T cg03315344 chr16:75512273 CHST6 0.49 9.5 0.46 4.32e-19 Dupuytren's disease; LUSC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg11494091 chr17:61959527 GH2 0.65 13.81 0.6 1.25e-34 Prudent dietary pattern; LUSC cis rs10927875 0.578 rs10927859 chr1:16141862 C/T cg21385522 chr1:16154831 NA -0.99 -18.42 -0.71 8.77e-53 Dilated cardiomyopathy; LUSC cis rs965469 1.000 rs2236089 chr20:3257194 C/A cg25506879 chr20:3388711 C20orf194 -0.51 -5.82 -0.3 1.39e-8 IFN-related cytopenia; LUSC trans rs208515 0.525 rs12204452 chr6:66680325 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.18 0.61 4.72e-36 Exhaled nitric oxide levels; LUSC cis rs7296418 0.699 rs11057254 chr12:123794581 A/C cg00376283 chr12:123451042 ABCB9 0.71 10.88 0.51 8.26e-24 Platelet count; LUSC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg12310025 chr6:25882481 NA 0.6 9.88 0.48 2.28e-20 Blood metabolite levels; LUSC cis rs76878669 0.561 rs1039594 chr11:66131149 C/T cg18002602 chr11:66138449 SLC29A2 0.45 8.12 0.41 8.95e-15 Educational attainment (years of education); LUSC cis rs151234 0.741 rs56236750 chr16:28594711 C/T cg01378222 chr16:28622494 SULT1A1 -0.63 -8.57 -0.42 3.94e-16 Platelet distribution width; LUSC cis rs782590 0.967 rs1084522 chr2:55843294 A/G cg18811423 chr2:55921094 PNPT1 0.83 14.67 0.63 6e-38 Metabolic syndrome; LUSC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg18758796 chr5:131593413 PDLIM4 0.42 7.12 0.36 6.72e-12 Breast cancer; LUSC cis rs10871290 1.000 rs10871290 chr16:74472696 C/T cg01733217 chr16:74700730 RFWD3 -0.56 -8.02 -0.4 1.83e-14 Breast cancer; LUSC cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg18681998 chr4:17616180 MED28 0.87 15.4 0.64 8.33e-41 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs2806561 0.765 rs641032 chr1:23513980 C/T cg19743168 chr1:23544995 NA -0.38 -7.45 -0.38 8.14e-13 Height; LUSC trans rs2243480 1.000 rs313814 chr7:65503293 C/A cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.58e-15 Diabetic kidney disease; LUSC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg27121462 chr16:89883253 FANCA 0.57 8.98 0.44 2e-17 Vitiligo; LUSC cis rs4718428 0.705 rs4718430 chr7:66432024 G/T cg12165864 chr7:66369176 NA -0.55 -7.14 -0.36 5.95e-12 Corneal structure; LUSC cis rs1267303 0.675 rs7519040 chr1:46986641 A/G cg25110126 chr1:46999211 NA 0.56 7.55 0.38 4.16e-13 Monobrow; LUSC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg00409905 chr10:38381863 ZNF37A -0.37 -6.3 -0.33 9.44e-10 Extrinsic epigenetic age acceleration; LUSC cis rs11098499 0.866 rs12499602 chr4:120284387 T/A cg09307838 chr4:120376055 NA 0.69 10.34 0.49 6.5e-22 Corneal astigmatism; LUSC cis rs8028313 0.630 rs4776373 chr15:67960523 G/A cg24579218 chr15:68104479 NA -0.39 -6.74 -0.35 6.88e-11 Obesity; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg04127825 chr1:167503222 NA 0.43 6.15 0.32 2.26e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7818345 0.967 rs4554480 chr8:19284072 G/A cg11303988 chr8:19266685 CSGALNACT1 0.39 7.5 0.38 5.68e-13 Language performance in older adults (adjusted for episodic memory); LUSC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg13939156 chr17:80058883 NA 0.33 6.45 0.33 3.87e-10 Life satisfaction; LUSC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg08847533 chr14:75593920 NEK9 -0.8 -13.77 -0.6 1.71e-34 Height; LUSC cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg27129171 chr3:47204927 SETD2 0.76 13.41 0.59 4.17e-33 Colorectal cancer; LUSC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg19920283 chr7:105172520 RINT1 0.57 6.14 0.32 2.39e-9 Bipolar disorder (body mass index interaction); LUSC cis rs11190604 1.000 rs11190604 chr10:102302457 A/G cg07080220 chr10:102295463 HIF1AN 0.7 9.43 0.46 7.36e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs814295 0.736 rs6744393 chr2:27750139 C/T cg27432699 chr2:27873401 GPN1 0.5 5.73 0.3 2.26e-8 Triglyceride levels; LUSC cis rs73198271 0.740 rs1039910 chr8:8648066 T/C cg01851573 chr8:8652454 MFHAS1 0.54 8.75 0.43 1.1e-16 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs7605827 0.930 rs7605730 chr2:15598696 A/G cg19274914 chr2:15703543 NA 0.47 9.07 0.44 1.06e-17 Educational attainment (years of education); LUSC cis rs7503807 1.000 rs12936076 chr17:78601195 C/T cg09596252 chr17:78655493 RPTOR 0.44 7.5 0.38 5.93e-13 Obesity; LUSC cis rs9517320 1.000 rs9584856 chr13:99126551 G/T cg20487152 chr13:99095054 FARP1 0.36 6.7 0.34 8.6e-11 Longevity; LUSC cis rs6969780 0.778 rs2465276 chr7:27145717 G/A cg26364809 chr7:27145159 NA -0.61 -6.12 -0.32 2.68e-9 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; LUSC cis rs9323205 0.798 rs2999391 chr14:51655109 A/G cg23942311 chr14:51606299 NA 0.37 7.73 0.39 1.3e-13 Cancer; LUSC cis rs4268898 0.610 rs55860688 chr2:24451534 T/C cg06627628 chr2:24431161 ITSN2 -0.87 -12.7 -0.57 2.01e-30 Asthma; LUSC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg00684032 chr4:1343700 KIAA1530 0.32 5.84 0.3 1.25e-8 Longevity; LUSC cis rs4964805 0.865 rs3935416 chr12:104206955 C/G cg02344784 chr12:104178138 NT5DC3 0.49 7.9 0.4 3.97e-14 Attention deficit hyperactivity disorder; LUSC cis rs10751667 0.600 rs7950955 chr11:1011490 G/A ch.11.42038R chr11:967971 AP2A2 0.45 6.58 0.34 1.79e-10 Alzheimer's disease (late onset); LUSC trans rs2797160 1.000 rs1739371 chr6:126011291 G/A cg05039488 chr6:79577232 IRAK1BP1 0.47 6.96 0.36 1.83e-11 Endometrial cancer; LUSC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg13393036 chr8:95962371 TP53INP1 0.44 9.17 0.45 4.87e-18 Type 2 diabetes; LUSC trans rs61931739 0.534 rs11053010 chr12:34093228 G/A cg13010199 chr12:38710504 ALG10B 0.56 8.45 0.42 9.2e-16 Morning vs. evening chronotype; LUSC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg26335602 chr6:28129616 ZNF389 0.43 5.74 0.3 2.17e-8 Depression; LUSC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.25 0.41 3.64e-15 Homoarginine levels; LUSC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg04414720 chr1:150670196 GOLPH3L -0.49 -7.7 -0.39 1.55e-13 Tonsillectomy; LUSC cis rs3862030 0.668 rs12781718 chr10:104227433 G/A cg22532475 chr10:104410764 TRIM8 0.25 5.87 0.31 1.03e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; LUSC cis rs7106204 1.000 rs6484025 chr11:24214514 C/G ch.11.24196551F chr11:24239977 NA 0.97 9.16 0.45 5.54e-18 Response to Homoharringtonine (cytotoxicity); LUSC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg03605463 chr16:89740564 NA 0.61 9.57 0.46 2.41e-19 Vitiligo; LUSC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg00149659 chr3:10157352 C3orf10 1.01 14.42 0.62 5.3e-37 Alzheimer's disease; LUSC cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -8.77 -0.43 8.96e-17 Monocyte percentage of white cells; LUSC cis rs2762353 0.562 rs1165206 chr6:25867566 G/A cg03264133 chr6:25882463 NA -0.4 -6.83 -0.35 4.06e-11 Blood metabolite levels; LUSC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg13390004 chr1:15929781 NA 0.4 6.69 0.34 9.64e-11 Systolic blood pressure; LUSC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.74 -0.3 2.14e-8 Depression; LUSC cis rs28829049 0.597 rs12745238 chr1:19393710 C/T cg13387374 chr1:19411106 UBR4 0.4 5.66 0.3 3.27e-8 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs3942852 0.955 rs1532754 chr11:48115279 A/T cg20307385 chr11:47447363 PSMC3 0.51 5.92 0.31 7.81e-9 Acute lymphoblastic leukemia (childhood); LUSC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg02034447 chr16:89574710 SPG7 -0.42 -6.3 -0.33 9.2e-10 Multiple myeloma (IgH translocation); LUSC cis rs6598955 0.627 rs12143920 chr1:26575834 A/G cg00852783 chr1:26633632 UBXN11 -0.48 -5.76 -0.3 1.96e-8 Obesity-related traits; LUSC cis rs3091242 1.000 rs3091242 chr1:25674785 C/T cg26659404 chr1:25747437 RHCE -0.28 -5.78 -0.3 1.7e-8 Erythrocyte sedimentation rate; LUSC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg04733989 chr22:42467013 NAGA 0.41 6.67 0.34 1.05e-10 Cognitive function; LUSC cis rs425277 0.539 rs3128337 chr1:2045882 A/G cg24578937 chr1:2090814 PRKCZ -0.43 -9.19 -0.45 4.33e-18 Height; LUSC cis rs3743266 0.613 rs1869484 chr15:60742063 G/T cg21667061 chr15:60772094 NARG2 -0.37 -6.27 -0.32 1.09e-9 Menarche (age at onset); LUSC cis rs7582180 0.629 rs6736576 chr2:100950854 C/T cg12002119 chr2:101014098 CHST10 0.36 5.99 0.31 5.44e-9 Intelligence (multi-trait analysis); LUSC cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg01483505 chr11:975446 AP2A2 0.4 5.81 0.3 1.44e-8 Alzheimer's disease (late onset); LUSC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg08219700 chr8:58056026 NA 0.67 8.68 0.43 1.75e-16 Developmental language disorder (linguistic errors); LUSC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg07741184 chr6:167504864 NA -0.35 -6.41 -0.33 4.84e-10 Crohn's disease; LUSC cis rs7572644 0.699 rs6738887 chr2:28268467 C/T cg27432699 chr2:27873401 GPN1 -0.53 -7.13 -0.36 6.07e-12 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg06636001 chr8:8085503 FLJ10661 0.65 10.69 0.5 3.96e-23 Mood instability; LUSC cis rs9479482 1.000 rs9479482 chr6:150358012 T/C cg03788504 chr6:150331562 NA -0.25 -5.74 -0.3 2.12e-8 Alopecia areata; LUSC cis rs2242116 0.796 rs4587 chr3:46963502 T/C cg16586182 chr3:47516702 SCAP -0.51 -7.17 -0.37 4.79e-12 Birth weight; LUSC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg24675056 chr1:15929824 NA 0.5 8.7 0.43 1.53e-16 Systolic blood pressure; LUSC cis rs28386778 0.735 rs2727336 chr17:61991965 G/C cg07677032 chr17:61819896 STRADA -0.49 -8.21 -0.41 4.77e-15 Prudent dietary pattern; LUSC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg21548772 chr3:47422338 PTPN23 0.37 6.15 0.32 2.21e-9 Asthma; LUSC cis rs12477438 0.765 rs28648058 chr2:99696417 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 -0.87 -12.87 -0.58 4.63e-31 Chronic sinus infection; LUSC trans rs11098499 0.588 rs2389874 chr4:120554991 A/G cg25214090 chr10:38739885 LOC399744 -0.41 -6.45 -0.33 3.97e-10 Corneal astigmatism; LUSC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg08798685 chr6:27730294 NA -0.42 -5.78 -0.3 1.7e-8 Parkinson's disease; LUSC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg03477792 chr4:77819574 ANKRD56 0.61 8.63 0.43 2.59e-16 Emphysema distribution in smoking; LUSC cis rs13108904 0.818 rs3775099 chr4:1232510 C/G cg16405210 chr4:1374714 KIAA1530 -0.47 -6.96 -0.36 1.77e-11 Obesity-related traits; LUSC cis rs11577318 0.538 rs10902745 chr1:26687070 G/C cg00852783 chr1:26633632 UBXN11 -0.54 -7.4 -0.38 1.09e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg03676636 chr4:99064102 C4orf37 0.34 7.39 0.37 1.22e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs10266483 0.739 rs10949900 chr7:63812129 A/G cg24201672 chr7:64023550 ZNF680 0.48 6.24 0.32 1.35e-9 Response to statin therapy; LUSC cis rs11711311 1.000 rs11719303 chr3:113494524 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.41 0.33 5.05e-10 IgG glycosylation; LUSC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg01420254 chr6:26195488 NA 0.66 7.31 0.37 2.05e-12 Gout;Renal underexcretion gout; LUSC trans rs11098499 0.820 rs28535956 chr4:120536858 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.48 -6.59 -0.34 1.76e-10 Corneal astigmatism; LUSC cis rs4664304 0.772 rs10183731 chr2:160740989 A/G cg03641300 chr2:160917029 PLA2R1 0.36 5.77 0.3 1.84e-8 Crohn's disease;Inflammatory bowel disease; LUSC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg21153622 chr11:89784906 NA -0.39 -6.08 -0.32 3.3e-9 Coronary artery disease; LUSC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18404041 chr3:52824283 ITIH1 -0.54 -10.39 -0.49 4.23e-22 Electroencephalogram traits; LUSC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg05738196 chr6:26577821 NA -0.48 -7.11 -0.36 6.88e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs4820539 1.000 rs3788347 chr22:23467804 G/A cg14186256 chr22:23484241 RTDR1 0.93 17.14 0.68 1.12e-47 Bone mineral density; LUSC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg12963246 chr6:28129442 ZNF389 0.43 6.15 0.32 2.26e-9 Depression; LUSC cis rs7107174 1.000 rs10899474 chr11:78043636 T/C cg02023728 chr11:77925099 USP35 0.46 6.72 0.34 8.05e-11 Testicular germ cell tumor; LUSC cis rs3741151 0.773 rs7950375 chr11:73281345 G/A cg17517138 chr11:73019481 ARHGEF17 0.98 8.2 0.41 5.31e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.89 0.55 1.95e-27 Prudent dietary pattern; LUSC cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg04733989 chr22:42467013 NAGA -0.47 -7.7 -0.39 1.5700000000000001e-13 Cognitive function; LUSC cis rs611744 0.870 rs635941 chr8:109235457 G/A cg18478394 chr8:109455254 TTC35 0.4 6.02 0.31 4.67e-9 Dupuytren's disease; LUSC cis rs6831352 0.918 rs3919370 chr4:100064326 A/T cg13256891 chr4:100009986 ADH5 -0.46 -6.12 -0.32 2.58e-9 Alcohol dependence; LUSC cis rs9300255 0.568 rs1621194 chr12:123651018 T/C cg05973401 chr12:123451056 ABCB9 0.54 6.67 0.34 1.06e-10 Neutrophil percentage of white cells; LUSC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg25072359 chr17:41440525 NA 0.64 9.02 0.44 1.51e-17 Menopause (age at onset); LUSC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.43 6.05 0.31 3.8e-9 Height; LUSC cis rs4718428 0.705 rs2901311 chr7:66415069 T/C cg18252515 chr7:66147081 NA -0.49 -6.47 -0.33 3.44e-10 Corneal structure; LUSC cis rs7707921 0.767 rs6894520 chr5:81594748 C/T cg15871215 chr5:81402204 ATG10 -0.42 -6.7 -0.34 8.79e-11 Breast cancer; LUSC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg05253716 chr12:129299332 SLC15A4;MGC16384 0.45 6.68 0.34 9.94e-11 Systemic lupus erythematosus; LUSC cis rs9420 0.961 rs11602109 chr11:57435296 G/A cg02958346 chr11:57425731 CLP1 -0.43 -6.33 -0.33 7.73e-10 Schizophrenia; LUSC cis rs11098499 0.618 rs28491261 chr4:120294900 C/A cg24375607 chr4:120327624 NA 0.78 11.35 0.53 1.82e-25 Corneal astigmatism; LUSC cis rs4499344 0.657 rs259238 chr19:33140381 A/G cg22980127 chr19:33182716 NUDT19 -0.48 -6.94 -0.35 2.06e-11 Mean platelet volume; LUSC cis rs12425451 0.552 rs10848765 chr12:3141495 C/T cg05389053 chr12:3131226 TEAD4 0.41 5.87 0.31 1.04e-8 Narcolepsy with cataplexy; LUSC cis rs735539 0.645 rs1411038 chr13:21248431 A/G cg04906043 chr13:21280425 IL17D -0.48 -7.76 -0.39 1.03e-13 Dental caries; LUSC cis rs34734847 0.871 rs2239760 chr12:121163518 C/A cg21892295 chr12:121157589 UNC119B -0.48 -8.55 -0.42 4.41e-16 Mean corpuscular volume; LUSC cis rs2204008 0.694 rs1672436 chr12:38132547 G/T cg13010199 chr12:38710504 ALG10B -0.52 -7.74 -0.39 1.16e-13 Bladder cancer; LUSC cis rs6977940 0.818 rs11765386 chr7:2894512 A/G cg19731401 chr7:2775893 GNA12 -0.58 -6.49 -0.33 3.16e-10 White matter integrity; LUSC cis rs10864907 0.614 rs10199311 chr2:113697961 C/T cg06156847 chr2:113672199 IL1F7 -0.28 -5.84 -0.3 1.27e-8 Pulmonary function; LUSC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg14893161 chr1:205819251 PM20D1 0.86 15.93 0.66 6.79e-43 Menarche (age at onset); LUSC cis rs6750047 0.605 rs59501228 chr2:38261972 A/C cg07380506 chr2:38303506 CYP1B1 -0.44 -6.13 -0.32 2.49e-9 Cutaneous malignant melanoma;Melanoma; LUSC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 8.79 0.43 8.11e-17 Axial length; LUSC trans rs11681884 0.786 rs1992763 chr2:113810736 T/A cg19632953 chr13:113635898 MCF2L 0.69 6.03 0.31 4.45e-9 Stroke; LUSC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg13683864 chr3:40499215 RPL14 1.09 21.26 0.76 4.94e-64 Renal cell carcinoma; LUSC cis rs4077515 0.967 rs4567159 chr9:139277059 G/A cg14019695 chr9:139328340 INPP5E 0.44 8.12 0.41 9.39e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; LUSC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg25243455 chr2:114033360 PAX8;LOC440839 -0.34 -7.68 -0.39 1.73e-13 Lymphocyte counts; LUSC cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg21535247 chr6:8435926 SLC35B3 0.58 9.1 0.45 8.31e-18 Motion sickness; LUSC cis rs708547 0.874 rs1713978 chr4:57875879 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.68 8.91 0.44 3.26e-17 Response to bleomycin (chromatid breaks); LUSC cis rs6084875 0.840 rs2422933 chr20:4720035 T/C cg07258627 chr20:4721683 PRNT -0.34 -6.14 -0.32 2.32e-9 Systemic lupus erythematosus; LUSC cis rs727505 0.954 rs989177 chr7:124412886 A/G cg14311320 chr7:124405732 GPR37 -0.33 -5.7 -0.3 2.64e-8 Lewy body disease; LUSC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg12463550 chr7:65579703 CRCP 0.62 5.67 0.3 3.04e-8 Diabetic kidney disease; LUSC cis rs561341 0.739 rs8070554 chr17:30216868 A/T cg00745463 chr17:30367425 LRRC37B 0.57 7.2 0.37 4.07e-12 Hip circumference adjusted for BMI; LUSC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg26597838 chr10:835615 NA 0.8 9.93 0.48 1.6e-20 Eosinophil percentage of granulocytes; LUSC cis rs9388451 0.805 rs1028481 chr6:126106573 G/T cg10911889 chr6:126070802 HEY2 0.42 6.39 0.33 5.59e-10 Brugada syndrome; LUSC cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg18132916 chr6:79620363 NA -0.37 -5.7 -0.3 2.6e-8 Intelligence (multi-trait analysis); LUSC cis rs9814567 1.000 rs7427492 chr3:134261654 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -13.68 -0.6 3.86e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7937682 0.921 rs7130753 chr11:111470567 C/T cg11344533 chr11:111475393 SIK2 0.46 6.07 0.32 3.56e-9 Primary sclerosing cholangitis; LUSC cis rs77741769 0.571 rs11065282 chr12:121264415 G/T cg02419362 chr12:121203948 SPPL3 0.45 8.34 0.41 2.04e-15 Mean corpuscular volume; LUSC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg23978390 chr7:1156363 C7orf50 0.5 7.07 0.36 9.07e-12 Longevity;Endometriosis; LUSC cis rs7760949 0.963 rs9475771 chr6:13914869 A/G cg27413430 chr6:13925136 RNF182 -0.54 -8.23 -0.41 4.34e-15 Mean corpuscular hemoglobin concentration; LUSC cis rs4629710 0.545 rs11154621 chr6:131547341 A/G cg12606694 chr6:131520996 AKAP7 0.57 8.82 0.43 6.68e-17 Multiple myeloma (IgH translocation); LUSC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.26 0.37 2.68e-12 Parkinson's disease; LUSC cis rs17286411 0.777 rs4788569 chr16:71914785 A/G cg03805757 chr16:71968109 PKD1L3 0.42 6.89 0.35 2.72e-11 Blood protein levels; LUSC cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg26384229 chr12:38710491 ALG10B 0.92 15.7 0.65 5.59e-42 Bladder cancer; LUSC cis rs9650315 0.929 rs4400356 chr8:57180161 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.52 6.82 0.35 4.17e-11 Height; LUSC cis rs1215050 0.765 rs783947 chr4:99012943 T/C cg05340658 chr4:99064831 C4orf37 -0.44 -6.99 -0.36 1.53e-11 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg08847533 chr14:75593920 NEK9 0.85 15.77 0.65 2.82e-42 Height; LUSC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg04315214 chr1:2043799 PRKCZ 0.39 7.45 0.38 8.27e-13 Height; LUSC cis rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05901451 chr6:126070800 HEY2 -0.79 -14.15 -0.61 6.28e-36 Brugada syndrome; LUSC cis rs2540226 0.816 rs9309042 chr2:40001889 G/A cg23576258 chr2:39999331 THUMPD2 0.33 5.69 0.3 2.83e-8 Personality dimensions; LUSC cis rs11764590 0.694 rs4721321 chr7:2068470 A/G cg19629631 chr7:2060116 MAD1L1 -0.35 -5.7 -0.3 2.68e-8 Neuroticism; LUSC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg18252515 chr7:66147081 NA -1.23 -13.63 -0.6 5.9e-34 Diabetic kidney disease; LUSC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg11218175 chr11:495084 RNH1 0.54 5.85 0.3 1.19e-8 Body mass index; LUSC cis rs9309473 0.607 rs6740173 chr2:73602266 C/G cg20560298 chr2:73613845 ALMS1 -0.57 -8.39 -0.42 1.39e-15 Metabolite levels; LUSC cis rs7267979 1.000 rs6083828 chr20:25369918 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.85 -19.39 -0.73 1.19e-56 Liver enzyme levels (alkaline phosphatase); LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg00945038 chr17:61921165 SMARCD2 0.54 9.72 0.47 8.06e-20 Prudent dietary pattern; LUSC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg11663144 chr21:46675770 NA -0.41 -7.03 -0.36 1.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg07395648 chr5:131743802 NA 0.47 7.62 0.38 2.7e-13 Breast cancer;Mosquito bite size; LUSC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg26338869 chr17:61819248 STRADA 0.42 6.17 0.32 1.99e-9 Prudent dietary pattern; LUSC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg13798912 chr7:905769 UNC84A -0.59 -5.99 -0.31 5.35e-9 Cerebrospinal P-tau181p levels; LUSC cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg08508325 chr11:3079039 CARS -0.51 -12.75 -0.57 1.35e-30 Longevity; LUSC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg03676636 chr4:99064102 C4orf37 0.36 7.93 0.4 3.38e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 6.05 0.31 3.86e-9 Mean platelet volume; LUSC cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg02380750 chr20:61661411 NA 0.33 5.83 0.3 1.32e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg18876405 chr7:65276391 NA -0.75 -13.41 -0.59 4.16e-33 Aortic root size; LUSC trans rs12637928 0.580 rs1533211 chr3:110186311 A/T cg17371621 chr15:61264283 RORA 0.36 6.07 0.32 3.39e-9 Neuroticism; LUSC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg16405210 chr4:1374714 KIAA1530 -0.52 -5.85 -0.3 1.18e-8 Recombination rate (females); LUSC cis rs1577917 1.000 rs10455456 chr6:86670322 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -8.44 -0.42 9.55e-16 Response to antipsychotic treatment; LUSC cis rs6845621 0.727 rs6837620 chr4:18898521 A/G cg12196642 chr4:18937545 NA -0.33 -6.11 -0.32 2.73e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU); LUSC cis rs5758659 1.000 rs134902 chr22:42683997 C/T cg15557168 chr22:42548783 NA -0.4 -6.8 -0.35 4.75e-11 Cognitive function; LUSC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.5 6.72 0.35 7.82e-11 Tonsillectomy; LUSC cis rs4803468 1.000 rs3213861 chr19:41919944 A/C cg09537434 chr19:41945824 ATP5SL -0.92 -15.94 -0.66 6.34e-43 Height; LUSC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.44 -7.07 -0.36 9.2e-12 Alzheimer's disease (late onset); LUSC cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg19628046 chr18:33552617 C18orf21 0.5 6.39 0.33 5.58e-10 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg17366294 chr4:99064904 C4orf37 0.55 9.01 0.44 1.63e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC cis rs8016982 0.662 rs1951616 chr14:81671752 T/C cg01989461 chr14:81687754 GTF2A1 0.51 6.83 0.35 3.91e-11 Schizophrenia; LUSC cis rs2130392 0.962 rs7660116 chr4:185626542 G/A cg04058563 chr4:185651563 MLF1IP 0.41 6.59 0.34 1.72e-10 Kawasaki disease; LUSC cis rs9581857 0.547 rs78273785 chr13:28052884 T/C cg22138327 chr13:27999177 GTF3A 0.77 8.21 0.41 4.96e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg21724239 chr8:58056113 NA 0.8 8.35 0.42 1.85e-15 Developmental language disorder (linguistic errors); LUSC trans rs11992162 0.573 rs13275808 chr8:11782815 T/C cg15556689 chr8:8085844 FLJ10661 -0.46 -6.76 -0.35 6.16e-11 Monocyte count; LUSC cis rs9473147 0.543 rs4711880 chr6:47480676 A/G cg20196966 chr6:47445060 CD2AP 0.41 5.79 0.3 1.66e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs79149102 0.579 rs28394281 chr15:75326754 C/G cg09165964 chr15:75287851 SCAMP5 -0.92 -8.63 -0.43 2.56e-16 Lung cancer; LUSC cis rs7267979 0.528 rs6076366 chr20:25564626 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.71 -12.72 -0.57 1.74e-30 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.63 0.86 5.12e-99 Chronic sinus infection; LUSC trans rs1997103 1.000 rs6951294 chr7:55400835 C/T cg20935933 chr6:143382018 AIG1 0.5 7.33 0.37 1.71e-12 QRS interval (sulfonylurea treatment interaction); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg06636316 chr19:30303495 CCNE1 -0.42 -6.21 -0.32 1.54e-9 Electrocardiographic conduction measures; LUSC cis rs72781680 0.716 rs2712079 chr2:24082061 G/A cg08917208 chr2:24149416 ATAD2B 0.6 6.95 0.36 1.97e-11 Lymphocyte counts; LUSC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11644478 chr21:40555479 PSMG1 0.95 18.98 0.72 5.3e-55 Cognitive function; LUSC cis rs6982240 0.569 rs6992278 chr8:142279383 C/G cg00131261 chr8:142287264 NA -0.38 -6.63 -0.34 1.38e-10 Tonsillectomy; LUSC cis rs3736594 0.513 rs62138965 chr2:27816593 T/C cg27432699 chr2:27873401 GPN1 0.66 8.73 0.43 1.25e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs2303759 0.914 rs2288481 chr19:49878196 G/A cg22307029 chr19:49891270 CCDC155 0.67 8.61 0.43 2.92e-16 Multiple sclerosis; LUSC cis rs1712517 0.873 rs1712510 chr10:105009086 A/G cg05636881 chr10:105038444 INA -0.42 -6.91 -0.35 2.4e-11 Migraine; LUSC cis rs9326248 0.510 rs4938332 chr11:116930798 A/G cg01368799 chr11:117014884 PAFAH1B2 0.61 9.31 0.45 1.77e-18 Blood protein levels; LUSC cis rs12579753 1.000 rs10862372 chr12:82249804 C/T cg07988820 chr12:82153109 PPFIA2 -0.43 -6.0 -0.31 5.12e-9 Resting heart rate; LUSC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg23303369 chr20:44641161 MMP9 -0.35 -6.09 -0.32 3.18e-9 Intelligence (multi-trait analysis); LUSC cis rs6121246 0.567 rs6058203 chr20:30198979 C/T cg18721089 chr20:30220636 NA -0.37 -5.76 -0.3 1.86e-8 Mean corpuscular hemoglobin; LUSC cis rs7833787 1.000 rs17383616 chr8:18704800 A/C cg17701159 chr8:18705777 PSD3 -0.36 -5.73 -0.3 2.2e-8 Obesity-related traits; LUSC cis rs1950626 0.623 rs61991083 chr14:101436435 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.4 7.47 0.38 7.07e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.44 -0.33 4.12e-10 Major depressive disorder; LUSC cis rs12618769 0.652 rs3754871 chr2:99224309 A/T cg10123293 chr2:99228465 UNC50 0.47 7.71 0.39 1.48e-13 Bipolar disorder; LUSC cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg15544633 chr2:99771531 LIPT1;TSGA10 1.19 27.66 0.83 2.24e-88 Chronic sinus infection; LUSC trans rs7829975 0.714 rs11784052 chr8:8671962 C/T cg27411982 chr8:10470053 RP1L1 0.42 6.72 0.35 7.89e-11 Mood instability; LUSC cis rs921968 0.643 rs611203 chr2:219472325 G/A cg02176678 chr2:219576539 TTLL4 0.6 10.98 0.52 3.66e-24 Mean corpuscular hemoglobin concentration; LUSC cis rs34779708 0.742 rs35912711 chr10:35312996 T/C cg04310649 chr10:35416472 CREM -0.4 -6.22 -0.32 1.52e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs9549260 0.755 rs4325426 chr13:41216437 C/A cg21288729 chr13:41239152 FOXO1 0.64 9.95 0.48 1.29e-20 Red blood cell count; LUSC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg20684491 chr1:25596433 NA 0.36 5.65 0.3 3.43e-8 Erythrocyte sedimentation rate; LUSC cis rs117352156 0.943 rs10508740 chr10:29220339 A/T cg06394621 chr10:29236369 NA -0.45 -5.91 -0.31 8.29e-9 Aggressiveness in attention deficit hyperactivity disorder; LUSC cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg17507749 chr15:85114479 UBE2QP1 -0.5 -5.74 -0.3 2.14e-8 Schizophrenia; LUSC cis rs7582180 0.652 rs11687865 chr2:100947000 T/A cg08017756 chr2:100939284 LONRF2 -0.46 -8.57 -0.42 3.91e-16 Intelligence (multi-trait analysis); LUSC cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg22509189 chr2:225307070 NA -0.49 -6.24 -0.32 1.33e-9 IgE levels in asthmatics (D.p. specific); LUSC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg22907277 chr7:1156413 C7orf50 0.68 7.31 0.37 2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs240764 0.853 rs2062634 chr6:101002618 G/C cg09795085 chr6:101329169 ASCC3 -0.41 -5.9 -0.31 9.04e-9 Neuroticism; LUSC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg03709012 chr19:19516395 GATAD2A 0.83 14.09 0.61 1.01e-35 Tonsillectomy; LUSC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg05340658 chr4:99064831 C4orf37 0.67 11.43 0.53 9.5e-26 Colonoscopy-negative controls vs population controls; LUSC cis rs12050794 0.671 rs62022788 chr15:72559326 T/G cg16672083 chr15:72433130 SENP8 0.47 7.8 0.39 7.96e-14 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2996428 0.629 rs12135894 chr1:3728061 C/T cg22529645 chr1:3704559 LRRC47 0.35 6.03 0.31 4.36e-9 Red cell distribution width; LUSC cis rs9640161 0.830 rs7800196 chr7:150061534 C/G cg10018233 chr7:150070692 REPIN1 0.36 6.61 0.34 1.48e-10 Blood protein levels;Circulating chemerin levels; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg08892416 chr16:89800313 ZNF276 -0.37 -6.32 -0.33 8.39e-10 Risky sexual behaviors in alcohol dependence; LUSC cis rs4363385 0.720 rs6680624 chr1:152983872 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.67 -0.39 1.9e-13 Inflammatory skin disease; LUSC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg06850241 chr22:41845214 NA 0.33 5.83 0.3 1.28e-8 Vitiligo; LUSC cis rs2439831 1.000 rs28628574 chr15:43802038 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.99 10.8 0.51 1.66e-23 Lung cancer in ever smokers; LUSC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg17968037 chr7:100024898 ZCWPW1 -0.39 -5.87 -0.31 1.07e-8 Platelet count; LUSC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg05368731 chr17:41323189 NBR1 0.95 16.07 0.66 1.92e-43 Menopause (age at onset); LUSC cis rs7177699 0.550 rs7182716 chr15:79123753 T/C cg00540400 chr15:79124168 NA 0.43 7.5 0.38 5.63e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs5769707 0.521 rs6009807 chr22:50058922 A/G cg10356904 chr22:49881777 NA -0.3 -5.94 -0.31 7.14e-9 Monocyte count;Monocyte percentage of white cells; LUSC cis rs829883 1.000 rs1347956 chr12:98889564 A/G cg25150519 chr12:98850993 NA 0.64 10.01 0.48 8.48e-21 Colorectal adenoma (advanced); LUSC cis rs9473147 0.543 rs9473126 chr6:47481833 C/G cg20196966 chr6:47445060 CD2AP 0.41 5.79 0.3 1.66e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7607369 0.536 rs12623007 chr2:219665335 T/C cg02176678 chr2:219576539 TTLL4 -0.51 -8.94 -0.44 2.63e-17 Red blood cell count;Amyotrophic lateral sclerosis; LUSC cis rs295140 0.933 rs10931900 chr2:201177193 T/C cg04283868 chr2:201171347 SPATS2L 0.43 6.56 0.34 2.08e-10 QT interval; LUSC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg22920501 chr2:26401640 FAM59B 0.81 12.05 0.55 5.03e-28 Gut microbiome composition (summer); LUSC cis rs10197940 0.662 rs4335940 chr2:152275304 A/G cg06191203 chr2:152266755 RIF1 0.51 6.99 0.36 1.46e-11 Lung cancer; LUSC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.1 17.14 0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg15790184 chr11:494944 RNH1 0.54 5.99 0.31 5.43e-9 Body mass index; LUSC cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg15839431 chr19:19639596 YJEFN3 -0.58 -6.41 -0.33 5.02e-10 Bipolar disorder; LUSC cis rs16854884 0.657 rs16854772 chr3:143703890 A/G cg06585982 chr3:143692056 C3orf58 0.45 6.86 0.35 3.29e-11 Economic and political preferences (feminism/equality); LUSC cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg09184832 chr6:79620586 NA -0.44 -7.1 -0.36 7.7e-12 Intelligence (multi-trait analysis); LUSC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg06600287 chr1:53387719 ECHDC2 -0.32 -6.56 -0.34 2.09e-10 Monocyte count; LUSC trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.32 -0.45 1.66e-18 Extrinsic epigenetic age acceleration; LUSC cis rs738322 0.555 rs5750549 chr22:38547172 C/T cg25457927 chr22:38595422 NA -0.4 -7.95 -0.4 2.85e-14 Cutaneous nevi; LUSC cis rs3820068 0.705 rs72645803 chr1:15868232 G/A cg17385448 chr1:15911702 AGMAT 0.38 5.79 0.3 1.61e-8 Systolic blood pressure; LUSC cis rs73206853 0.609 rs7966169 chr12:111045898 T/C cg12870014 chr12:110450643 ANKRD13A 0.69 7.58 0.38 3.37e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg14298792 chr15:30685198 CHRFAM7A -0.49 -5.97 -0.31 5.95e-9 Huntington's disease progression; LUSC cis rs2548003 0.518 rs967080 chr5:28755831 T/C cg22863700 chr5:28928346 NA 0.42 6.04 0.31 4.19e-9 Hip geometry; LUSC cis rs1784581 0.894 rs1626020 chr6:162383379 G/A cg17173639 chr6:162384350 PARK2 -0.8 -15.02 -0.63 2.55e-39 Itch intensity from mosquito bite; LUSC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg13397359 chr6:42928475 GNMT 0.59 9.78 0.47 5.06e-20 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs1451375 0.959 rs1451373 chr7:50622606 A/G cg18232548 chr7:50535776 DDC 0.51 7.83 0.39 6.32e-14 Malaria; LUSC cis rs4363385 0.574 rs6683514 chr1:152984397 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -6.03 -0.31 4.32e-9 Inflammatory skin disease; LUSC cis rs4423214 0.559 rs10898228 chr11:71228358 A/T cg05163923 chr11:71159392 DHCR7 -0.69 -7.12 -0.36 6.62e-12 Vitamin D levels; LUSC cis rs7212938 0.509 rs3893044 chr17:38103016 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.99 0.4 2.2e-14 Asthma and hay fever; LUSC cis rs6121246 0.697 rs6087716 chr20:30229040 C/T cg21427119 chr20:30132790 HM13 -0.42 -6.27 -0.32 1.1e-9 Mean corpuscular hemoglobin; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03031660 chr17:73257791 MRPS7;GGA3 0.37 6.62 0.34 1.47e-10 Triglycerides; LUSC cis rs11997175 0.624 rs12677772 chr8:33772521 T/C ch.8.33884649F chr8:33765107 NA 0.51 7.8 0.39 7.91e-14 Body mass index; LUSC cis rs9467773 1.000 rs9467774 chr6:26505036 C/A cg09904177 chr6:26538194 HMGN4 0.73 13.27 0.59 1.45e-32 Intelligence (multi-trait analysis); LUSC cis rs3087591 0.960 rs12603885 chr17:29466722 C/T cg24425628 chr17:29625626 OMG;NF1 0.56 8.03 0.4 1.69e-14 Hip circumference; LUSC cis rs7804356 1.000 rs12536145 chr7:26894860 A/T cg03456212 chr7:26904342 SKAP2 -0.52 -6.04 -0.31 4.16e-9 Type 1 diabetes; LUSC cis rs422249 0.547 rs174533 chr11:61549025 G/A cg19610905 chr11:61596333 FADS2 -0.54 -8.08 -0.4 1.17e-14 Trans fatty acid levels; LUSC cis rs9886651 0.905 rs10110243 chr8:128805020 A/G cg07795030 chr8:128802207 NA -0.35 -6.22 -0.32 1.53e-9 Epithelial ovarian cancer;Serous invasive ovarian cancer; LUSC cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC cis rs9660992 0.512 rs12142402 chr1:205128215 A/T cg21545522 chr1:205238299 TMCC2 0.47 8.76 0.43 1.02e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4631830 0.720 rs12763717 chr10:51500874 C/G cg10326726 chr10:51549505 MSMB 0.34 5.77 0.3 1.76e-8 Prostate-specific antigen levels; LUSC cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg10518543 chr12:38710700 ALG10B 0.4 5.7 0.3 2.68e-8 Morning vs. evening chronotype; LUSC trans rs61931739 0.500 rs7309421 chr12:34553795 C/T cg13010199 chr12:38710504 ALG10B 0.66 10.33 0.49 6.76e-22 Morning vs. evening chronotype; LUSC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg13628971 chr7:2884303 GNA12 0.38 5.84 0.3 1.22e-8 Height; LUSC cis rs1878931 0.580 rs8062722 chr16:3409161 G/A cg00484396 chr16:3507460 NAT15 -0.37 -6.21 -0.32 1.53e-9 Body mass index (adult); LUSC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg02569458 chr12:86230093 RASSF9 0.61 10.31 0.49 8.24e-22 Major depressive disorder; LUSC cis rs76878669 0.538 rs1785633 chr11:66107527 C/A cg24851651 chr11:66362959 CCS -0.37 -5.92 -0.31 8.01e-9 Educational attainment (years of education); LUSC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.56e-10 Menopause (age at onset); LUSC cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg19077165 chr18:44547161 KATNAL2 -0.38 -5.75 -0.3 1.98e-8 Personality dimensions; LUSC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg26924012 chr15:45694286 SPATA5L1 1.12 20.7 0.75 8.1e-62 Homoarginine levels; LUSC cis rs9768139 0.524 rs6459860 chr7:158136362 C/A cg06219351 chr7:158114137 PTPRN2 0.49 7.7 0.39 1.53e-13 Calcium levels; LUSC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg19592336 chr6:28129416 ZNF389 0.55 7.18 0.37 4.6e-12 Parkinson's disease; LUSC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg26408565 chr15:76604113 ETFA 0.47 7.43 0.38 8.89e-13 Blood metabolite levels; LUSC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg12927641 chr6:109611667 NA 0.36 6.1 0.32 2.99e-9 Reticulocyte fraction of red cells; LUSC cis rs35883536 0.647 rs12026951 chr1:101046273 C/T cg06223162 chr1:101003688 GPR88 -0.47 -8.81 -0.43 6.81e-17 Monocyte count; LUSC cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg13319975 chr6:146136371 FBXO30 0.5 7.44 0.38 8.58e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg08085267 chr17:45401833 C17orf57 -0.54 -8.57 -0.42 3.77e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.18 -0.32 1.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs1325195 0.881 rs1173077 chr1:179220878 C/T cg11624085 chr17:8464688 MYH10 0.43 7.01 0.36 1.33e-11 IgE grass sensitization; LUSC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg06634786 chr22:41940651 POLR3H 0.49 6.12 0.32 2.56e-9 Vitiligo; LUSC trans rs61931739 0.500 rs11053278 chr12:34555955 T/C cg13010199 chr12:38710504 ALG10B 0.57 9.04 0.44 1.26e-17 Morning vs. evening chronotype; LUSC cis rs7296418 0.961 rs10848428 chr12:123572495 C/T cg13010344 chr12:123464640 ARL6IP4 -0.53 -8.44 -0.42 1e-15 Platelet count; LUSC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg02187348 chr16:89574699 SPG7 0.61 10.03 0.48 7.29e-21 Multiple myeloma (IgH translocation); LUSC cis rs12530845 0.623 rs73721662 chr7:135341314 G/A cg23117316 chr7:135346802 PL-5283 -0.63 -9.65 -0.47 1.31e-19 Red blood cell traits; LUSC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg25566285 chr7:158114605 PTPRN2 0.34 6.53 0.34 2.45e-10 Calcium levels; LUSC cis rs6542838 0.583 rs7565819 chr2:99519265 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.47 -6.36 -0.33 6.74e-10 Fear of minor pain; LUSC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg03684893 chr10:554711 DIP2C -0.37 -6.81 -0.35 4.68e-11 Psychosis in Alzheimer's disease; LUSC cis rs72781680 0.800 rs72790306 chr2:24111311 T/G cg20701182 chr2:24300061 SF3B14 0.74 7.6 0.38 3.07e-13 Lymphocyte counts; LUSC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.83 0.6 1.04e-34 Platelet count; LUSC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg03676636 chr4:99064102 C4orf37 0.33 7.17 0.37 4.89e-12 Colonoscopy-negative controls vs population controls; LUSC cis rs7760949 0.889 rs9396272 chr6:13938080 C/T cg27413430 chr6:13925136 RNF182 -0.55 -8.44 -0.42 9.95e-16 Mean corpuscular hemoglobin concentration; LUSC cis rs7180079 0.502 rs8033972 chr15:64524980 G/A cg08069370 chr15:64387884 SNX1 -0.45 -6.52 -0.34 2.57e-10 Monocyte count; LUSC cis rs4343996 0.967 rs34608458 chr7:3357881 G/A cg21248987 chr7:3385318 SDK1 -0.39 -6.62 -0.34 1.41e-10 Motion sickness; LUSC cis rs988712 0.705 rs10501087 chr11:27670108 C/T cg10635145 chr11:27742435 BDNF 0.45 5.88 0.31 1.01e-8 Obesity; LUSC cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg18132916 chr6:79620363 NA -0.38 -5.85 -0.3 1.17e-8 Intelligence (multi-trait analysis); LUSC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 7.62 0.38 2.66e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs6543140 0.601 rs78178597 chr2:103023596 G/T cg09003973 chr2:102972529 NA 0.73 8.63 0.43 2.53e-16 Blood protein levels; LUSC trans rs12210905 0.688 rs78285097 chr6:27374644 G/C cg14616345 chr9:133901267 LAMC3 -0.65 -5.95 -0.31 6.6e-9 Hip circumference adjusted for BMI; LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg22638593 chr5:131593259 PDLIM4 0.44 6.28 0.33 1.05e-9 Acylcarnitine levels; LUSC cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg11266682 chr4:10021025 SLC2A9 -0.57 -10.59 -0.5 8.37e-23 Bone mineral density; LUSC cis rs2901656 1.000 rs6691993 chr1:172426998 T/G cg03748243 chr1:172413542 C1orf105;PIGC 0.3 6.01 0.31 4.78e-9 Red cell distribution width;Platelet distribution width; LUSC cis rs11630290 1.000 rs72750987 chr15:63999112 G/C cg12036633 chr15:63758958 NA -0.73 -8.18 -0.41 6.2e-15 Iris characteristics; LUSC cis rs9467711 0.659 rs13216828 chr6:26373507 G/A cg09904177 chr6:26538194 HMGN4 -0.75 -7.04 -0.36 1.12e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs1153858 0.723 rs11855527 chr15:45606685 G/A cg14582100 chr15:45693742 SPATA5L1 -0.54 -9.1 -0.45 8.12e-18 Homoarginine levels; LUSC cis rs7582720 1.000 rs72936304 chr2:204036357 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 8.55 0.42 4.56e-16 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7106204 0.534 rs75297923 chr11:24253530 A/G ch.11.24196551F chr11:24239977 NA 0.72 6.09 0.32 3.05e-9 Response to Homoharringtonine (cytotoxicity); LUSC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg00024416 chr22:24240387 NA -0.34 -5.91 -0.31 8.55e-9 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs17685 0.753 rs4573217 chr7:75733946 G/A cg19862616 chr7:65841803 NCRNA00174 1.13 19.75 0.73 4.68e-58 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs10740039 1.000 rs10761541 chr10:62415141 C/G cg18175470 chr10:62150864 ANK3 -0.42 -6.84 -0.35 3.7e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs11048434 0.761 rs10842660 chr12:9138897 G/A cg23795048 chr12:9217529 LOC144571 0.34 5.83 0.3 1.32e-8 Sjögren's syndrome; LUSC cis rs892961 0.899 rs8071024 chr17:75414067 T/C cg05865280 chr17:75406074 SEPT9 0.46 9.67 0.47 1.13e-19 Airflow obstruction; LUSC cis rs11645898 0.935 rs3812985 chr16:72187957 A/T cg14768367 chr16:72042858 DHODH -0.53 -6.35 -0.33 7.16e-10 Blood protein levels; LUSC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.68 12.01 0.55 7.58e-28 Personality dimensions; LUSC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg06001716 chr17:41278141 BRCA1;NBR2 0.4 6.39 0.33 5.7e-10 Menopause (age at onset); LUSC cis rs4595586 0.525 rs4511319 chr12:39340457 T/C cg13010199 chr12:38710504 ALG10B 0.42 6.01 0.31 4.75e-9 Morning vs. evening chronotype; LUSC cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg03146154 chr1:46216737 IPP 0.55 8.32 0.41 2.34e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12227505 chr17:78194145 SLC26A11;SGSH -0.48 -6.99 -0.36 1.47e-11 Bipolar disorder and schizophrenia; LUSC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg05368731 chr17:41323189 NBR1 0.93 16.14 0.66 1.04e-43 Menopause (age at onset); LUSC cis rs7264396 0.943 rs1810741 chr20:34109715 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -5.68 -0.3 2.98e-8 Total cholesterol levels; LUSC cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.14 -0.36 5.7e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7589342 0.894 rs6736932 chr2:106444854 A/G cg16077055 chr2:106428750 NCK2 0.35 6.77 0.35 5.86e-11 Addiction; LUSC trans rs17685 0.753 rs2868203 chr7:75680026 G/A cg19862616 chr7:65841803 NCRNA00174 -1.13 -20.08 -0.74 2.19e-59 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg16405210 chr4:1374714 KIAA1530 -0.54 -8.38 -0.42 1.45e-15 Obesity-related traits; LUSC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg17724175 chr1:150552817 MCL1 -0.37 -6.81 -0.35 4.57e-11 Tonsillectomy; LUSC cis rs12701220 0.572 rs7792825 chr7:1006573 T/C cg04102894 chr7:1000210 NA -0.24 -5.81 -0.3 1.47e-8 Bronchopulmonary dysplasia; LUSC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg17724175 chr1:150552817 MCL1 0.37 6.6 0.34 1.63e-10 Tonsillectomy; LUSC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg01191920 chr7:158217561 PTPRN2 -0.52 -10.81 -0.51 1.5e-23 Obesity-related traits; LUSC cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg23158103 chr7:148848205 ZNF398 -0.5 -8.34 -0.42 1.92e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg07701084 chr6:150067640 NUP43 0.56 8.74 0.43 1.15e-16 Lung cancer; LUSC cis rs1670533 1.000 rs6837145 chr4:1071067 T/C cg27284194 chr4:1044797 NA 0.58 8.7 0.43 1.55e-16 Recombination rate (females); LUSC cis rs67460515 0.563 rs1599388 chr3:160846866 A/G cg03342759 chr3:160939853 NMD3 -0.45 -6.33 -0.33 7.76e-10 Parkinson's disease; LUSC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.61 0.34 1.54e-10 Menopause (age at onset); LUSC cis rs11190604 1.000 rs74650218 chr10:102293830 C/T cg07080220 chr10:102295463 HIF1AN 0.68 9.2 0.45 3.94e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1559088 0.948 rs2019603 chr19:33577367 C/T cg03563238 chr19:33554763 RHPN2 0.39 6.33 0.33 7.88e-10 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg27446573 chr6:127587934 RNF146 0.91 14.87 0.63 9.5e-39 Breast cancer; LUSC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.47 7.07 0.36 9.19e-12 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg00310523 chr12:86230176 RASSF9 0.52 9.88 0.48 2.27e-20 Major depressive disorder; LUSC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg26597838 chr10:835615 NA 1.23 16.83 0.68 1.93e-46 Eosinophil percentage of granulocytes; LUSC cis rs2235649 0.663 rs12596160 chr16:1848784 G/A cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.11 -0.32 2.76e-9 Blood metabolite levels; LUSC cis rs9467711 0.516 rs1324088 chr6:25841122 C/T cg08501292 chr6:25962987 TRIM38 0.57 6.09 0.32 3.19e-9 Autism spectrum disorder or schizophrenia; LUSC cis rs2289583 0.642 rs12148697 chr15:75384375 G/T cg14664628 chr15:75095509 CSK -0.43 -5.83 -0.3 1.28e-8 Systemic lupus erythematosus; LUSC cis rs4285028 0.699 rs73855465 chr3:121574219 C/T cg11130432 chr3:121712080 ILDR1 -0.62 -9.38 -0.46 1.03e-18 Multiple sclerosis; LUSC cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg11742103 chr11:62369870 EML3;MTA2 0.54 8.7 0.43 1.54e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs17155006 0.664 rs402113 chr7:107743664 A/G cg05962710 chr7:107745446 LAMB4 -0.34 -6.07 -0.32 3.53e-9 Pneumococcal bacteremia; LUSC cis rs9527 0.590 rs10883836 chr10:104891198 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.84 0.47 3.19e-20 Arsenic metabolism; LUSC cis rs10489202 0.657 rs3767479 chr1:168069840 C/A cg24449463 chr1:168025552 DCAF6 -0.67 -10.05 -0.48 6.15e-21 Schizophrenia; LUSC cis rs17854409 1.000 rs6011427 chr20:61496680 C/T cg07645718 chr20:61493192 TCFL5 0.73 5.74 0.3 2.11e-8 Obesity-related traits; LUSC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg23281280 chr6:28129359 ZNF389 -0.46 -6.01 -0.31 4.83e-9 Parkinson's disease; LUSC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg16584290 chr5:462447 EXOC3 -0.35 -6.16 -0.32 2.13e-9 Cystic fibrosis severity; LUSC cis rs243505 0.660 rs3779038 chr7:148542822 C/T cg09806900 chr7:148480153 CUL1 0.49 6.45 0.33 3.88e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg25072359 chr17:41440525 NA 0.66 9.28 0.45 2.14e-18 Menopause (age at onset); LUSC cis rs7246657 0.943 rs3803895 chr19:37898669 A/G cg23950597 chr19:37808831 NA -0.62 -7.57 -0.38 3.68e-13 Coronary artery calcification; LUSC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg13628971 chr7:2884303 GNA12 -0.45 -6.67 -0.34 1.08e-10 Height; LUSC cis rs8017423 0.935 rs2104704 chr14:90696609 A/G cg14092571 chr14:90743983 NA 0.36 5.78 0.3 1.71e-8 Mortality in heart failure; LUSC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg21951975 chr1:209979733 IRF6 0.58 6.64 0.34 1.24e-10 Coronary artery disease; LUSC cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg11266682 chr4:10021025 SLC2A9 -0.5 -9.12 -0.45 7.26e-18 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg19638132 chr11:59521665 STX3 0.45 6.59 0.34 1.68e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11190604 1.000 rs10509744 chr10:102271579 C/T cg16342193 chr10:102329863 NA -0.37 -6.78 -0.35 5.45e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs1865760 1.000 rs6905887 chr6:25912103 T/C cg16482183 chr6:26056742 HIST1H1C 0.44 6.58 0.34 1.77e-10 Height; LUSC trans rs961253 0.522 rs6085496 chr20:6315656 C/T cg21095983 chr6:86352623 SYNCRIP 0.53 7.78 0.39 9.08e-14 Colorectal cancer; LUSC cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg08975724 chr8:8085496 FLJ10661 0.52 7.54 0.38 4.43e-13 Mood instability; LUSC cis rs4450131 0.902 rs10794174 chr10:126357981 T/C cg20435097 chr10:126320824 FAM53B -0.22 -5.79 -0.3 1.63e-8 White blood cell count (basophil); LUSC cis rs7107174 0.901 rs2450139 chr11:77924544 G/A cg02023728 chr11:77925099 USP35 0.48 7.03 0.36 1.17e-11 Testicular germ cell tumor; LUSC cis rs12956009 0.583 rs11663609 chr18:44862757 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 6.38 0.33 5.91e-10 Educational attainment (years of education); LUSC cis rs1577917 0.839 rs12055653 chr6:86546663 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -6.47 -0.33 3.55e-10 Response to antipsychotic treatment; LUSC cis rs4665809 0.652 rs12611790 chr2:26404221 C/T cg26314531 chr2:26401878 FAM59B -0.69 -9.24 -0.45 3.03e-18 Gut microbiome composition (summer); LUSC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg04414720 chr1:150670196 GOLPH3L 0.49 7.78 0.39 9.11e-14 Melanoma; LUSC cis rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05901451 chr6:126070800 HEY2 -0.77 -13.95 -0.61 3.72e-35 Brugada syndrome; LUSC cis rs3749237 0.964 rs2352967 chr3:49871641 C/T cg03060546 chr3:49711283 APEH 0.56 8.0 0.4 2.14e-14 Resting heart rate; LUSC cis rs3799977 0.531 rs62436031 chr6:44722203 A/G cg25276700 chr6:44698697 NA 0.3 6.25 0.32 1.24e-9 Attention deficit hyperactivity disorder; LUSC cis rs12148488 0.966 rs1867149 chr15:75339993 C/T cg14664628 chr15:75095509 CSK 0.43 6.16 0.32 2.11e-9 Caffeine consumption; LUSC cis rs7296418 0.961 rs11608811 chr12:123529056 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.39 -7.31 -0.37 1.98e-12 Platelet count; LUSC cis rs2708977 1.000 rs2708977 chr2:97230074 G/A cg01950434 chr2:97203154 ARID5A -0.55 -8.39 -0.42 1.36e-15 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs8014204 0.762 rs10139018 chr14:75274292 T/C cg06637938 chr14:75390232 RPS6KL1 0.52 8.09 0.4 1.08e-14 Caffeine consumption; LUSC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg05340658 chr4:99064831 C4orf37 0.66 11.27 0.53 3.37e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs858239 0.601 rs929508 chr7:23166709 C/A cg23682824 chr7:23144976 KLHL7 0.4 5.82 0.3 1.4e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.44 6.38 0.33 6.05e-10 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs2324229 0.828 rs1180204 chr6:83956724 A/G cg08257003 chr6:84140564 ME1 -0.26 -5.91 -0.31 8.35e-9 Platelet-derived growth factor BB levels; LUSC cis rs9549367 0.636 rs486407 chr13:113833499 G/A cg00898013 chr13:113819073 PROZ 0.55 8.23 0.41 4.22e-15 Platelet distribution width; LUSC cis rs12681287 0.640 rs6471309 chr8:87387760 C/T cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.64e-12 Caudate activity during reward; LUSC cis rs9646944 0.501 rs2293223 chr2:103035468 C/T cg20060108 chr2:102954350 IL1RL1 0.48 6.51 0.34 2.8e-10 Blood protein levels; LUSC cis rs1965732 0.958 rs6755529 chr2:3711972 C/T cg10645314 chr2:3704589 ALLC 0.37 6.43 0.33 4.49e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs7945718 0.934 rs10831907 chr11:12790875 C/T cg25843174 chr11:12811716 TEAD1 -0.32 -7.14 -0.36 5.68e-12 Educational attainment (years of education); LUSC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg14004847 chr7:1930337 MAD1L1 -0.52 -7.94 -0.4 3.01e-14 Schizophrenia; LUSC cis rs6005807 0.719 rs12167434 chr22:29040821 C/T cg12565055 chr22:29076175 TTC28 0.54 5.86 0.31 1.12e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs8062405 0.755 rs4788073 chr16:28594549 A/G cg16576597 chr16:28551801 NUPR1 0.3 6.24 0.32 1.34e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs9399135 0.967 rs6910530 chr6:135332770 C/T cg22676075 chr6:135203613 NA 0.47 7.49 0.38 6.25e-13 Red blood cell count; LUSC cis rs13315871 1.000 rs4367085 chr3:58389235 A/G cg12435725 chr3:58293450 RPP14 -0.73 -7.35 -0.37 1.56e-12 Cholesterol, total; LUSC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg18252515 chr7:66147081 NA 1.23 14.12 0.61 8.1e-36 Diabetic kidney disease; LUSC cis rs10761482 0.954 rs10821714 chr10:62065131 T/C cg18175470 chr10:62150864 ANK3 -0.45 -6.26 -0.32 1.2e-9 Schizophrenia; LUSC cis rs16910800 0.731 rs16910738 chr11:23189455 C/T cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs9348739 1 rs9348739 chr6:26923099 G/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.44 -5.78 -0.3 1.7e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg02569458 chr12:86230093 RASSF9 0.58 9.93 0.48 1.56e-20 Major depressive disorder; LUSC cis rs2398893 0.889 rs2039313 chr9:96781684 C/G cg14459158 chr9:96720562 NA -0.29 -5.65 -0.3 3.4e-8 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg18827107 chr12:86230957 RASSF9 0.46 6.96 0.36 1.86e-11 Major depressive disorder; LUSC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg04944784 chr2:26401820 FAM59B 0.76 11.18 0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs12760731 0.565 rs12047117 chr1:178132608 G/A cg00404053 chr1:178313656 RASAL2 0.66 6.8 0.35 4.85e-11 Obesity-related traits; LUSC cis rs3741151 0.764 rs7101561 chr11:73264219 G/C cg17517138 chr11:73019481 ARHGEF17 0.98 8.16 0.41 6.67e-15 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg23283495 chr1:209979779 IRF6 0.68 8.38 0.42 1.51e-15 Cleft lip with or without cleft palate; LUSC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg14019146 chr3:50243930 SLC38A3 0.36 8.02 0.4 1.78e-14 Body mass index; LUSC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg10621924 chr7:39171070 POU6F2 0.46 7.25 0.37 2.86e-12 IgG glycosylation; LUSC cis rs9650315 0.866 rs35811702 chr8:57187244 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.88 0.35 3.01e-11 Height; LUSC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg17279839 chr7:150038598 RARRES2 0.52 7.74 0.39 1.23e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs9457247 0.967 rs1794696 chr6:167396174 T/C cg07741184 chr6:167504864 NA 0.39 6.96 0.36 1.85e-11 Crohn's disease; LUSC cis rs1322512 0.713 rs1744390 chr6:152937489 C/T cg27316956 chr6:152958899 SYNE1 -0.36 -5.94 -0.31 7.06e-9 Tonometry; LUSC cis rs7843479 1.000 rs67385415 chr8:21853733 T/C cg17168535 chr8:21777572 XPO7 0.68 10.16 0.49 2.6e-21 Mean corpuscular volume; LUSC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg04450456 chr4:17643702 FAM184B 0.39 6.51 0.34 2.77e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.84 -0.57 5.91e-31 Alzheimer's disease; LUSC cis rs10779751 1.000 rs7544489 chr1:11299511 A/G cg08854313 chr1:11322531 MTOR -0.92 -16.84 -0.68 1.64e-46 Body mass index; LUSC cis rs1335645 0.570 rs11805357 chr1:111651660 G/C cg00321911 chr1:111669324 DRAM2 -0.6 -6.29 -0.33 9.88e-10 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg07828024 chr6:149772892 ZC3H12D -0.33 -7.35 -0.37 1.55e-12 Dupuytren's disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19693015 chr17:78965712 CHMP6 -0.43 -6.42 -0.33 4.68e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12618769 0.652 rs3754872 chr2:99223925 A/T cg10123293 chr2:99228465 UNC50 0.46 7.55 0.38 4.26e-13 Bipolar disorder; LUSC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg07959070 chr22:50026188 C22orf34 -0.34 -7.05 -0.36 1.01e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs2708977 0.965 rs2314109 chr2:97243532 A/G cg01950434 chr2:97203154 ARID5A -0.56 -8.55 -0.42 4.38e-16 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; LUSC cis rs10876993 0.855 rs1689604 chr12:58048304 T/C cg15848620 chr12:58087721 OS9 -0.53 -7.55 -0.38 4.25e-13 Celiac disease or Rheumatoid arthritis; LUSC cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg06462663 chr19:18546047 ISYNA1 0.48 8.16 0.41 6.81e-15 Breast cancer; LUSC cis rs1997103 1.000 rs1997098 chr7:55405594 G/T cg17469321 chr7:55412551 NA 0.66 10.62 0.5 6.87e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg13010199 chr12:38710504 ALG10B 0.69 11.38 0.53 1.39e-25 Heart rate; LUSC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg09034736 chr1:150693464 HORMAD1 0.48 6.98 0.36 1.62e-11 Tonsillectomy; LUSC cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg07606381 chr6:8435919 SLC35B3 0.74 12.48 0.56 1.36e-29 Motion sickness; LUSC cis rs17253792 0.822 rs10151664 chr14:56029533 A/G cg01858014 chr14:56050164 KTN1 -0.65 -6.12 -0.32 2.68e-9 Putamen volume; LUSC cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg07741184 chr6:167504864 NA 0.52 9.12 0.45 7.33e-18 Crohn's disease; LUSC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg14092988 chr3:52407081 DNAH1 0.32 6.15 0.32 2.19e-9 Bipolar disorder; LUSC cis rs72949976 0.864 rs10176806 chr2:214022596 T/G cg08319019 chr2:214017104 IKZF2 -0.61 -9.2 -0.45 4.12e-18 Lung cancer;Squamous cell lung carcinoma; LUSC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg03709012 chr19:19516395 GATAD2A 0.85 14.66 0.63 6.35e-38 Tonsillectomy; LUSC cis rs11155671 0.530 rs6933882 chr6:150210802 A/G cg09699651 chr6:150184138 LRP11 0.45 7.17 0.37 4.98e-12 Testicular germ cell tumor; LUSC cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -7.22 -0.37 3.46e-12 Monocyte percentage of white cells; LUSC cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg16797656 chr11:68205561 LRP5 0.49 8.86 0.44 4.76e-17 Total body bone mineral density; LUSC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.65 8.21 0.41 4.72e-15 Lung function (FEV1/FVC); LUSC trans rs853679 0.824 rs1321505 chr6:28052823 A/C cg01620082 chr3:125678407 NA -0.57 -6.28 -0.32 1.05e-9 Depression; LUSC cis rs55883249 0.958 rs113937820 chr2:9746668 A/G cg23886495 chr2:9695866 ADAM17 0.51 6.03 0.31 4.3e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg20295408 chr7:1910781 MAD1L1 -0.44 -6.28 -0.32 1.07e-9 Bipolar disorder and schizophrenia; LUSC cis rs2276314 1.000 rs4799832 chr18:33559646 T/C cg05985134 chr18:33552581 C18orf21 0.51 6.91 0.35 2.5e-11 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg23649088 chr2:200775458 C2orf69 0.52 6.92 0.35 2.3e-11 Schizophrenia; LUSC cis rs4700695 0.719 rs36923 chr5:65464783 G/C cg21114390 chr5:65439923 SFRS12 -0.65 -9.18 -0.45 4.52e-18 Facial morphology (factor 19); LUSC cis rs9549260 0.753 rs1986649 chr13:41178824 C/T cg21288729 chr13:41239152 FOXO1 0.53 5.96 0.31 6.31e-9 Red blood cell count; LUSC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg14196790 chr5:131705035 SLC22A5 0.43 7.17 0.37 4.74e-12 Blood metabolite levels; LUSC cis rs4803468 1.000 rs3816037 chr19:41918009 C/T cg09537434 chr19:41945824 ATP5SL -0.91 -16.24 -0.66 4.18e-44 Height; LUSC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg02269571 chr22:50332266 NA -0.57 -8.59 -0.43 3.41e-16 Schizophrenia; LUSC trans rs561341 0.882 rs563539 chr17:30307958 A/G cg20587970 chr11:113659929 NA -1.13 -15.62 -0.65 1.09e-41 Hip circumference adjusted for BMI; LUSC cis rs68170813 0.521 rs61673847 chr7:106892431 A/G cg02696742 chr7:106810147 HBP1 -0.65 -9.83 -0.47 3.27e-20 Coronary artery disease; LUSC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18099408 chr3:52552593 STAB1 -0.46 -8.18 -0.41 6.16e-15 Bipolar disorder; LUSC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg20933634 chr6:27740509 NA -0.46 -6.25 -0.32 1.27e-9 Parkinson's disease; LUSC cis rs4474465 1.000 rs4944200 chr11:78166930 C/A cg27205649 chr11:78285834 NARS2 -0.48 -5.74 -0.3 2.12e-8 Alzheimer's disease (survival time); LUSC cis rs41271473 0.687 rs7535661 chr1:228887667 C/T cg16512390 chr1:228756714 NA 0.49 6.56 0.34 2.03e-10 Chronic lymphocytic leukemia; LUSC cis rs7909074 0.966 rs879074 chr10:45400053 G/A cg04218760 chr10:45406644 TMEM72 -0.28 -6.76 -0.35 6.15e-11 Mean corpuscular volume; LUSC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg07701084 chr6:150067640 NUP43 0.54 8.2 0.41 5.08e-15 Lung cancer; LUSC trans rs1728785 0.901 rs1728787 chr16:68593042 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.63 8.22 0.41 4.57e-15 Ulcerative colitis; LUSC cis rs7098414 0.511 rs4934126 chr10:82151598 A/G cg01528321 chr10:82214614 TSPAN14 0.61 9.07 0.44 1.06e-17 Post bronchodilator FEV1; LUSC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg23583168 chr7:148888333 NA -0.88 -16.44 -0.67 6.47e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg03806693 chr22:41940476 POLR3H 0.9 12.43 0.56 2.06e-29 Vitiligo; LUSC cis rs10979 1.000 rs12211659 chr6:143898348 G/T cg25407410 chr6:143891975 LOC285740 -0.74 -12.07 -0.55 4.41e-28 Hypospadias; LUSC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg27535305 chr1:53392650 SCP2 0.37 6.77 0.35 5.83e-11 Monocyte count; LUSC cis rs3540 0.574 rs8035980 chr15:90974390 C/G cg10434728 chr15:90938212 IQGAP1 0.39 8.11 0.41 9.52e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs6987853 0.814 rs2923411 chr8:42455206 T/C cg09913449 chr8:42400586 C8orf40 0.44 7.42 0.38 9.89e-13 Mean corpuscular hemoglobin concentration; LUSC cis rs13223928 0.554 rs13438334 chr7:3156956 G/A cg19214707 chr7:3157722 NA -0.53 -9.52 -0.46 3.63e-19 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; LUSC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg23758822 chr17:41437982 NA 1.03 19.24 0.73 4.58e-56 Menopause (age at onset); LUSC cis rs72781680 0.848 rs6748727 chr2:24041058 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs2180341 0.597 rs3798859 chr6:127663116 C/T cg24812749 chr6:127587940 RNF146 0.64 9.54 0.46 3.05e-19 Breast cancer; LUSC cis rs9311676 0.656 rs56232415 chr3:58394850 C/T cg26110898 chr3:58419937 PDHB 0.4 6.42 0.33 4.6e-10 Systemic lupus erythematosus; LUSC cis rs11190604 0.943 rs11190574 chr10:102234331 T/C cg07080220 chr10:102295463 HIF1AN 0.65 8.42 0.42 1.09e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.38 5.72 0.3 2.31e-8 Intelligence (multi-trait analysis); LUSC cis rs2573652 0.722 rs11636084 chr15:100543394 A/G cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.35 -0.33 6.83e-10 Height; LUSC trans rs6964587 1.000 rs6942649 chr7:91594510 A/G cg16374953 chr13:31191680 USPL1 0.4 6.91 0.35 2.47e-11 Breast cancer; LUSC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg11890956 chr21:40555474 PSMG1 0.87 10.79 0.51 1.67e-23 Cognitive function; LUSC cis rs4243830 0.850 rs10864612 chr1:6593830 C/G cg05709478 chr1:6581295 PLEKHG5 -0.5 -5.9 -0.31 8.78e-9 Body mass index; LUSC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg17178900 chr1:205818956 PM20D1 0.8 13.53 0.6 1.43e-33 Menarche (age at onset); LUSC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg18827107 chr12:86230957 RASSF9 -0.48 -7.17 -0.37 4.97e-12 Major depressive disorder; LUSC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23221052 chr5:179740743 GFPT2 -0.66 -10.56 -0.5 1.09e-22 Height; LUSC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg19346786 chr7:2764209 NA -0.49 -8.27 -0.41 3.2e-15 Height; LUSC cis rs12586317 0.582 rs731906 chr14:35604543 C/T cg16230307 chr14:35515116 FAM177A1 0.8 9.77 0.47 5.46e-20 Psoriasis; LUSC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg24881330 chr22:46731750 TRMU 0.89 8.94 0.44 2.7e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs13088645 0.532 rs7623580 chr3:134164345 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.47 6.32 0.33 8.13e-10 Coronary artery disease; LUSC cis rs3931020 0.688 rs277396 chr1:75213648 A/C cg00121533 chr1:75199117 CRYZ;TYW3 -0.48 -6.1 -0.32 2.92e-9 Resistin levels; LUSC trans rs853679 1.000 rs7740487 chr6:28216486 C/G cg06606381 chr12:133084897 FBRSL1 -0.59 -6.71 -0.34 8.46e-11 Depression; LUSC trans rs8073060 0.586 rs6505484 chr17:33993152 G/A cg19694781 chr19:47549865 TMEM160 -1.15 -18.25 -0.71 4.26e-52 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; LUSC cis rs55665837 1.000 rs12283797 chr11:14442262 C/G cg05501817 chr11:14380813 RRAS2 -0.41 -6.61 -0.34 1.51e-10 Vitamin D levels; LUSC cis rs3857536 0.785 rs6455089 chr6:66944733 A/C cg07460842 chr6:66804631 NA -0.46 -6.42 -0.33 4.59e-10 Blood trace element (Cu levels); LUSC cis rs2797160 0.508 rs9375404 chr6:125927895 G/A cg05901451 chr6:126070800 HEY2 -0.41 -5.8 -0.3 1.51e-8 Endometrial cancer; LUSC cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.35 -0.46 1.3e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7202877 0.610 rs3844219 chr16:75370230 G/T cg03315344 chr16:75512273 CHST6 0.42 6.22 0.32 1.49e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.45 7.25 0.37 2.91e-12 Intelligence (multi-trait analysis); LUSC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -7.58 -0.38 3.36e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs3847687 1.000 rs11061303 chr12:131526322 A/G cg13586425 chr12:131519906 GPR133 -0.25 -5.83 -0.3 1.3e-8 Longevity; LUSC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg18190219 chr22:46762943 CELSR1 -0.49 -6.08 -0.32 3.25e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs150647904 1 rs150647904 chr1:54839485 T/TCAG cg17417004 chr1:54819992 SSBP3 0.52 6.3 0.33 9.41e-10 Platelet distribution width; LUSC cis rs4363385 0.740 rs4845518 chr1:153003903 A/G cg00922841 chr1:152955080 SPRR1A -0.44 -7.7 -0.39 1.54e-13 Inflammatory skin disease; LUSC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg26314531 chr2:26401878 FAM59B -0.73 -9.65 -0.47 1.3e-19 Gut microbiome composition (summer); LUSC cis rs11098499 0.754 rs17595608 chr4:120250506 C/T cg09307838 chr4:120376055 NA 0.7 10.57 0.5 1.06e-22 Corneal astigmatism; LUSC trans rs7937682 0.632 rs57414412 chr11:111769431 G/A cg18187862 chr3:45730750 SACM1L -0.53 -6.42 -0.33 4.73e-10 Primary sclerosing cholangitis; LUSC cis rs6599077 1.000 rs9873761 chr3:40086208 A/G cg13683864 chr3:40499215 RPL14 0.55 7.29 0.37 2.28e-12 Sleep-related phenotypes; LUSC cis rs7824557 0.767 rs7003241 chr8:11169075 A/G cg21775007 chr8:11205619 TDH 0.72 11.71 0.54 9.09e-27 Retinal vascular caliber; LUSC cis rs7945705 0.870 rs1109305 chr11:8955272 C/T cg12365402 chr11:9010492 NRIP3 0.48 8.86 0.44 4.68e-17 Hemoglobin concentration; LUSC cis rs500891 0.574 rs13203553 chr6:84121882 A/G cg08257003 chr6:84140564 ME1 -0.34 -7.61 -0.38 2.91e-13 Platelet-derived growth factor BB levels; LUSC cis rs10779751 0.727 rs4845852 chr1:11233559 C/T cg08854313 chr1:11322531 MTOR 0.87 13.89 0.61 6.08e-35 Body mass index; LUSC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg08508325 chr11:3079039 CARS -0.53 -13.12 -0.58 5.14e-32 Longevity; LUSC cis rs7582180 0.903 rs7421891 chr2:100902166 G/A cg08017756 chr2:100939284 LONRF2 -0.36 -6.16 -0.32 2.12e-9 Intelligence (multi-trait analysis); LUSC cis rs6964587 0.933 rs28671255 chr7:91770705 A/G cg17063962 chr7:91808500 NA 0.58 9.3 0.45 1.96e-18 Breast cancer; LUSC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg19592336 chr6:28129416 ZNF389 0.44 5.76 0.3 1.92e-8 Parkinson's disease; LUSC cis rs965469 1.000 rs6051838 chr20:3389012 A/C cg25506879 chr20:3388711 C20orf194 -0.52 -5.76 -0.3 1.93e-8 IFN-related cytopenia; LUSC cis rs4363385 0.530 rs6663448 chr1:152894627 C/T cg25856811 chr1:152973957 SPRR3 -0.38 -6.16 -0.32 2.15e-9 Inflammatory skin disease; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23894768 chr18:5295771 ZFP161 -0.4 -6.07 -0.32 3.39e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg06784218 chr1:46089804 CCDC17 -0.5 -10.06 -0.48 5.91e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg22920501 chr2:26401640 FAM59B -0.79 -11.77 -0.54 5.48e-27 Gut microbiome composition (summer); LUSC cis rs67311347 0.544 rs2123998 chr3:40359005 C/G cg09455208 chr3:40491958 NA -0.43 -7.67 -0.39 1.87e-13 Renal cell carcinoma; LUSC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg02475777 chr4:1388615 CRIPAK 0.49 7.16 0.36 5.17e-12 Obesity-related traits; LUSC cis rs611744 0.647 rs9969614 chr8:109260581 A/G cg18478394 chr8:109455254 TTC35 0.41 6.33 0.33 8.11e-10 Dupuytren's disease; LUSC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg07636037 chr3:49044803 WDR6 0.44 6.38 0.33 5.9e-10 Resting heart rate; LUSC cis rs17270561 0.609 rs7746609 chr6:25727996 C/T cg16482183 chr6:26056742 HIST1H1C -0.56 -8.01 -0.4 1.97e-14 Iron status biomarkers; LUSC cis rs3809566 0.710 rs4075583 chr15:63340227 C/T cg00520135 chr15:63333846 TPM1 -0.27 -5.65 -0.3 3.38e-8 Platelet count; LUSC cis rs16866061 1.000 rs11694987 chr2:225397409 C/G cg12698349 chr2:225449008 CUL3 0.79 12.29 0.56 6.86e-29 Acute graft versus host disease in bone marrow transplantation (recipient effect); LUSC cis rs1712517 0.771 rs7074749 chr10:105116056 C/T cg05636881 chr10:105038444 INA 0.41 6.75 0.35 6.73e-11 Migraine; LUSC cis rs2282802 0.651 rs10060071 chr5:139599097 T/C cg26211634 chr5:139558579 C5orf32 0.42 7.9 0.4 4.06e-14 Intelligence (multi-trait analysis); LUSC cis rs35883536 0.647 rs10875316 chr1:101044150 G/A cg06223162 chr1:101003688 GPR88 -0.49 -9.24 -0.45 2.89e-18 Monocyte count; LUSC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg25072359 chr17:41440525 NA 0.63 9.17 0.45 4.88e-18 Menopause (age at onset); LUSC trans rs867371 0.502 rs7176926 chr15:82538094 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.32 -0.33 8.38e-10 Cognitive ability;Cognitive ability (multi-trait analysis); LUSC cis rs500891 0.533 rs3798886 chr6:84131526 G/A cg08257003 chr6:84140564 ME1 0.36 8.73 0.43 1.27e-16 Platelet-derived growth factor BB levels; LUSC cis rs1775715 0.707 rs2799024 chr10:32166922 A/G cg26784012 chr10:32216390 ARHGAP12 0.47 7.91 0.4 3.91e-14 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg09367891 chr1:107599246 PRMT6 0.52 8.02 0.4 1.81e-14 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.74 -7.55 -0.38 4.3e-13 Initial pursuit acceleration; LUSC cis rs1997103 0.954 rs10246216 chr7:55390479 C/T cg17469321 chr7:55412551 NA 0.68 10.92 0.51 5.92e-24 QRS interval (sulfonylurea treatment interaction); LUSC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs9303401 0.659 rs34170300 chr17:56789905 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.64 0.6 5.79e-34 Cognitive test performance; LUSC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg10172584 chr19:19639581 YJEFN3 -0.46 -5.65 -0.3 3.42e-8 Bipolar disorder; LUSC cis rs4237845 0.537 rs4237844 chr12:58267987 A/G cg00677455 chr12:58241039 CTDSP2 -0.69 -10.37 -0.49 4.85e-22 Intelligence (multi-trait analysis); LUSC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg11663144 chr21:46675770 NA -0.41 -7.19 -0.37 4.2e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3126085 0.877 rs4415568 chr1:152181207 G/A cg26876637 chr1:152193138 HRNR 0.42 5.89 0.31 9.36e-9 Atopic dermatitis; LUSC cis rs9322817 0.691 rs1933804 chr6:105341969 G/C cg02098413 chr6:105308735 HACE1 0.28 5.96 0.31 6.53e-9 Thyroid stimulating hormone; LUSC trans rs2727020 0.553 rs61904166 chr11:49581461 T/C cg15704280 chr7:45808275 SEPT13 -1.06 -20.24 -0.74 5.17e-60 Coronary artery disease; LUSC trans rs7824557 0.628 rs6601580 chr8:11193736 T/G cg15556689 chr8:8085844 FLJ10661 0.47 6.97 0.36 1.72e-11 Retinal vascular caliber; LUSC cis rs6121246 0.909 rs6060821 chr20:30294034 C/T cg21427119 chr20:30132790 HM13 -0.36 -5.66 -0.3 3.29e-8 Mean corpuscular hemoglobin; LUSC trans rs10432489 0.708 rs4315481 chr2:181761394 T/C cg04744134 chr19:8408128 KANK3 -0.79 -6.36 -0.33 6.73e-10 QT interval; LUSC cis rs10744422 0.858 rs4759389 chr12:123308615 A/G cg25930673 chr12:123319894 HIP1R -0.65 -6.43 -0.33 4.51e-10 Schizophrenia; LUSC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg10523679 chr1:76189770 ACADM -0.88 -13.99 -0.61 2.57e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg03351412 chr1:154909251 PMVK 0.53 8.21 0.41 4.97e-15 Prostate cancer; LUSC cis rs11958404 0.860 rs6885815 chr5:157437253 C/T cg05962755 chr5:157440814 NA 0.54 6.37 0.33 6.16e-10 IgG glycosylation; LUSC cis rs6977660 0.714 rs28371050 chr7:19816882 C/T cg07541023 chr7:19748670 TWISTNB 0.63 6.84 0.35 3.87e-11 Thyroid stimulating hormone; LUSC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 16.09 0.66 1.51e-43 Platelet count; LUSC trans rs1448094 0.817 rs10779220 chr12:86323543 T/A cg16660971 chr17:78860029 RPTOR 0.37 6.01 0.31 4.78e-9 Major depressive disorder; LUSC cis rs7223966 1.000 rs6504169 chr17:61709145 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.8 0.35 4.9e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.59 0.46 2.1e-19 Hip circumference adjusted for BMI; LUSC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13126279 chr21:47581558 C21orf56 0.56 8.66 0.43 2.02e-16 Testicular germ cell tumor; LUSC cis rs7177699 0.525 rs7166770 chr15:79113568 A/G cg00540400 chr15:79124168 NA 0.46 8.1 0.41 1.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs61931739 0.963 rs3912355 chr12:34079616 A/G cg06521331 chr12:34319734 NA -0.4 -6.52 -0.34 2.55e-10 Morning vs. evening chronotype; LUSC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg20607287 chr7:12443886 VWDE -0.59 -6.14 -0.32 2.35e-9 Coronary artery disease; LUSC cis rs1941023 0.503 rs894591 chr11:60132647 T/C cg08716584 chr11:60157161 MS4A7 -0.63 -11.86 -0.54 2.53e-27 Congenital heart disease (maternal effect); LUSC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg24675056 chr1:15929824 NA 0.46 8.03 0.4 1.69e-14 Systolic blood pressure; LUSC cis rs8062405 0.723 rs62031562 chr16:28609329 A/T cg07382826 chr16:28625726 SULT1A1 0.28 6.08 0.32 3.3e-9 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg00431813 chr7:1051703 C7orf50 -0.44 -7.06 -0.36 9.57e-12 Longevity;Endometriosis; LUSC cis rs9329221 0.905 rs4610752 chr8:10248962 A/G cg27411982 chr8:10470053 RP1L1 -0.49 -7.93 -0.4 3.4e-14 Neuroticism; LUSC cis rs9921338 0.924 rs7204628 chr16:11444572 A/C cg00044050 chr16:11439710 C16orf75 -0.49 -6.74 -0.35 6.99e-11 Vein graft stenosis in coronary artery bypass grafting; LUSC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg08280861 chr8:58055591 NA 0.54 6.48 0.33 3.2e-10 Developmental language disorder (linguistic errors); LUSC cis rs8114671 1.000 rs8114671 chr20:33789142 C/A cg07148914 chr20:33460835 GGT7 -0.44 -6.58 -0.34 1.82e-10 Height; LUSC trans rs1994089 0.781 rs67486235 chr17:33517652 G/T cg25602930 chr2:9533887 ASAP2 0.44 6.44 0.33 4.22e-10 Macrophage inflammatory protein 1b levels; LUSC cis rs782590 0.935 rs10460508 chr2:55882565 A/C cg18811423 chr2:55921094 PNPT1 0.86 15.47 0.65 4.49e-41 Metabolic syndrome; LUSC cis rs1790761 0.967 rs12573992 chr11:67197757 A/G cg24690094 chr11:67383802 NA -0.31 -5.68 -0.3 2.96e-8 Mean corpuscular volume; LUSC cis rs6089584 0.526 rs6061965 chr20:60607858 A/C cg24733560 chr20:60626293 TAF4 0.41 7.64 0.39 2.37e-13 Body mass index; LUSC cis rs3091242 0.900 rs1811832 chr1:25753565 G/A cg23205692 chr1:25664452 TMEM50A 0.4 5.81 0.3 1.46e-8 Erythrocyte sedimentation rate; LUSC cis rs4363385 0.693 rs440598 chr1:153044733 T/C cg00922841 chr1:152955080 SPRR1A -0.43 -7.39 -0.37 1.19e-12 Inflammatory skin disease; LUSC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg12463550 chr7:65579703 CRCP 0.62 5.67 0.3 3.04e-8 Diabetic kidney disease; LUSC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg13939156 chr17:80058883 NA -0.33 -6.56 -0.34 2.08e-10 Life satisfaction; LUSC cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg20891558 chr2:74357851 NA 0.79 14.33 0.62 1.24e-36 Gestational age at birth (maternal effect); LUSC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.23 0.52 4.89e-25 Prudent dietary pattern; LUSC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg00933542 chr6:150070202 PCMT1 0.29 5.88 0.31 9.93e-9 Lung cancer; LUSC cis rs7267979 0.873 rs6037062 chr20:25202892 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.78 16.52 0.67 3.11e-45 Liver enzyme levels (alkaline phosphatase); LUSC cis rs8077889 1.000 rs2880329 chr17:41866168 T/A cg26893861 chr17:41843967 DUSP3 1.01 15.05 0.64 1.87e-39 Triglycerides; LUSC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg06028605 chr16:24865363 SLC5A11 0.69 10.95 0.51 4.74e-24 Intelligence (multi-trait analysis); LUSC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg17724175 chr1:150552817 MCL1 -0.47 -8.35 -0.42 1.79e-15 Blood protein levels; LUSC cis rs2742234 0.590 rs2742237 chr10:43621323 C/G cg15436174 chr10:43711423 RASGEF1A -0.44 -7.13 -0.36 6.31e-12 Hirschsprung disease; LUSC cis rs72960926 0.744 rs77045321 chr6:74915572 T/C cg03266952 chr6:74778945 NA -0.79 -6.42 -0.33 4.66e-10 Metabolite levels (MHPG); LUSC cis rs9902453 0.716 rs3098949 chr17:27978694 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 10.43 0.5 3.03e-22 Coffee consumption (cups per day); LUSC cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg26384229 chr12:38710491 ALG10B 0.85 14.34 0.62 1.09e-36 Bladder cancer; LUSC cis rs9646954 0.542 rs11674830 chr2:101024735 A/G cg08017756 chr2:100939284 LONRF2 -0.47 -8.86 -0.44 4.94e-17 Intelligence (multi-trait analysis); LUSC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg16989086 chr20:62203971 PRIC285 0.47 6.53 0.34 2.46e-10 Glioblastoma; LUSC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg16989086 chr20:62203971 PRIC285 -0.44 -6.34 -0.33 7.58e-10 Glioblastoma; LUSC cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg11266682 chr4:10021025 SLC2A9 0.59 10.66 0.5 4.93e-23 Bone mineral density; LUSC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg05861140 chr6:150128134 PCMT1 -0.44 -6.92 -0.35 2.33e-11 Lung cancer; LUSC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.67 11.26 0.52 3.93e-25 Menarche (age at onset); LUSC cis rs12891047 0.804 rs7149482 chr14:68286295 C/T cg20999565 chr14:68265668 ZFYVE26 0.38 5.79 0.3 1.58e-8 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs12760731 0.720 rs12048790 chr1:178407906 T/C cg00404053 chr1:178313656 RASAL2 0.59 6.22 0.32 1.46e-9 Obesity-related traits; LUSC cis rs134594 1.000 rs134600 chr22:29472884 T/C cg03665785 chr22:29458676 C22orf31 0.28 5.75 0.3 1.96e-8 Birth weight; LUSC cis rs28829049 0.597 rs72651403 chr1:19519887 G/C cg13387374 chr1:19411106 UBR4 0.45 6.3 0.33 9.61e-10 QRS duration in Tripanosoma cruzi seropositivity; LUSC cis rs2952156 0.883 rs2517960 chr17:37846521 T/C cg00129232 chr17:37814104 STARD3 -0.48 -7.09 -0.36 8.24e-12 Asthma; LUSC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg05890377 chr2:74357713 NA 0.72 13.8 0.6 1.34e-34 Gestational age at birth (maternal effect); LUSC cis rs12421382 0.615 rs11607972 chr11:109392155 A/G cg11473876 chr11:109292803 C11orf87 0.41 6.58 0.34 1.82e-10 Schizophrenia; LUSC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg06740227 chr12:86229804 RASSF9 0.39 6.25 0.32 1.23e-9 Major depressive disorder; LUSC cis rs6982240 0.514 rs10481391 chr8:142277149 A/G cg27411547 chr8:142287226 NA -0.49 -8.28 -0.41 3.1e-15 Tonsillectomy; LUSC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs11051970 0.879 rs2651363 chr12:32587550 G/T cg02745156 chr12:32552066 NA -0.39 -6.77 -0.35 5.66e-11 Response to tocilizumab in rheumatoid arthritis; LUSC trans rs2786098 0.611 rs4316386 chr1:197515777 A/T cg16005942 chr6:160526640 IGF2R -0.48 -5.95 -0.31 6.88e-9 Asthma; LUSC cis rs3857536 0.741 rs2097679 chr6:66937994 T/C cg07460842 chr6:66804631 NA -0.47 -6.47 -0.33 3.47e-10 Blood trace element (Cu levels); LUSC cis rs72781680 0.898 rs56315094 chr2:23941952 T/C cg20701182 chr2:24300061 SF3B14 0.55 5.7 0.3 2.69e-8 Lymphocyte counts; LUSC cis rs7084921 0.608 rs12761969 chr10:101832036 G/C cg02250046 chr10:101825185 CPN1 -0.34 -6.13 -0.32 2.45e-9 Bone mineral density; LUSC cis rs10779751 0.734 rs2748877 chr1:11129437 T/C cg08854313 chr1:11322531 MTOR 0.8 12.45 0.56 1.6800000000000001e-29 Body mass index; LUSC trans rs561341 1.000 rs55959993 chr17:30254771 C/G cg27661571 chr11:113659931 NA -0.66 -7.51 -0.38 5.31e-13 Hip circumference adjusted for BMI; LUSC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg10360139 chr7:1886902 MAD1L1 -0.45 -6.93 -0.35 2.17e-11 Bipolar disorder and schizophrenia; LUSC cis rs6547741 1.000 rs6737921 chr2:27839107 T/C cg12559939 chr2:27858050 GPN1 0.41 6.48 0.33 3.28e-10 Oral cavity cancer; LUSC cis rs9296092 0.517 rs76662639 chr6:33508476 G/A cg13560919 chr6:33536144 NA -0.84 -14.68 -0.63 5.34e-38 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs9326248 0.581 rs6589582 chr11:116829200 A/C cg26566898 chr11:117069891 TAGLN 0.37 7.05 0.36 1.03e-11 Blood protein levels; LUSC cis rs6700896 0.500 rs12145237 chr1:66124882 C/T cg14976592 chr1:65886160 LEPROT;LEPR 0.52 5.93 0.31 7.6e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg07636037 chr3:49044803 WDR6 0.44 6.29 0.33 9.67e-10 Resting heart rate; LUSC cis rs1866706 0.896 rs1866711 chr11:12875301 C/T cg25843174 chr11:12811716 TEAD1 -0.28 -5.71 -0.3 2.53e-8 Intelligence (multi-trait analysis); LUSC cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg06784218 chr1:46089804 CCDC17 -0.47 -8.92 -0.44 3.06e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg25072359 chr17:41440525 NA 0.6 8.61 0.43 2.86e-16 Menopause (age at onset); LUSC cis rs9309473 1.000 rs10179134 chr2:73637519 A/G cg20560298 chr2:73613845 ALMS1 -0.44 -6.18 -0.32 1.85e-9 Metabolite levels; LUSC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg26116260 chr4:7069785 GRPEL1 -1.1 -12.83 -0.57 6.3e-31 Monocyte percentage of white cells; LUSC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg22963979 chr7:1858916 MAD1L1 -0.55 -8.39 -0.42 1.43e-15 Bipolar disorder and schizophrenia; LUSC trans rs7937682 0.663 rs3867466 chr11:111668256 A/C cg18187862 chr3:45730750 SACM1L -0.52 -6.32 -0.33 8.29e-10 Primary sclerosing cholangitis; LUSC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg12463550 chr7:65579703 CRCP 0.52 7.55 0.38 4.29e-13 Aortic root size; LUSC cis rs7582180 0.629 rs12612809 chr2:100951616 G/T cg12002119 chr2:101014098 CHST10 0.35 5.77 0.3 1.77e-8 Intelligence (multi-trait analysis); LUSC cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC cis rs2425143 0.643 rs6058324 chr20:34388789 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -5.71 -0.3 2.51e-8 Blood protein levels; LUSC cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg17366294 chr4:99064904 C4orf37 0.61 10.74 0.51 2.7e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs4974559 0.947 rs28711287 chr4:1346682 G/C cg02980000 chr4:1222292 CTBP1 0.74 7.35 0.37 1.54e-12 Systolic blood pressure; LUSC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg23985595 chr17:80112537 CCDC57 -0.31 -6.03 -0.31 4.41e-9 Life satisfaction; LUSC cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg23711669 chr6:146136114 FBXO30 0.76 13.72 0.6 2.76e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs4664304 0.934 rs72957586 chr2:160762687 G/A cg03641300 chr2:160917029 PLA2R1 -0.41 -6.78 -0.35 5.38e-11 Crohn's disease;Inflammatory bowel disease; LUSC cis rs12893668 0.645 rs35229468 chr14:104052057 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -6.1 -0.32 3.01e-9 Reticulocyte count; LUSC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg06634786 chr22:41940651 POLR3H 0.52 6.04 0.31 4.17e-9 Vitiligo; LUSC cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.58 -0.46 2.34e-19 Chronic sinus infection; LUSC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg24110177 chr3:50126178 RBM5 0.55 9.1 0.45 8.4e-18 Intelligence (multi-trait analysis); LUSC trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg20587970 chr11:113659929 NA -1.16 -16.04 -0.66 2.41e-43 Hip circumference adjusted for BMI; LUSC cis rs5770917 1.000 rs17848459 chr22:51012311 G/T cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.67 -0.3 3.03e-8 Narcolepsy; LUSC cis rs709400 0.628 rs7154246 chr14:103876794 G/A cg10523860 chr14:103875565 MARK3 0.39 6.21 0.32 1.55e-9 Body mass index; LUSC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg00290607 chr11:67383545 NA -0.41 -7.89 -0.4 4.41e-14 Mean corpuscular volume; LUSC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg19077165 chr18:44547161 KATNAL2 -0.39 -5.75 -0.3 2.04e-8 Personality dimensions; LUSC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg06915202 chr7:98029285 BAIAP2L1 -0.3 -5.98 -0.31 5.6e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs58688157 0.960 rs1131665 chr11:613208 T/C cg05717871 chr11:638507 DRD4 -0.34 -5.9 -0.31 8.74e-9 Systemic lupus erythematosus; LUSC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg20243544 chr17:37824526 PNMT 0.48 6.1 0.32 2.86e-9 Glomerular filtration rate (creatinine); LUSC cis rs950169 0.544 rs2036949 chr15:85163605 T/C cg11189052 chr15:85197271 WDR73 0.5 6.34 0.33 7.64e-10 Schizophrenia; LUSC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 7.64 0.39 2.32e-13 Hip circumference adjusted for BMI; LUSC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 15.51 0.65 3.1e-41 Platelet count; LUSC cis rs11031096 0.502 rs1442726 chr11:4094748 G/C cg18678763 chr11:4115507 RRM1 -0.47 -6.09 -0.32 3.1e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs870825 0.929 rs72689258 chr4:185590550 G/C cg04058563 chr4:185651563 MLF1IP 0.83 11.29 0.53 2.87e-25 Blood protein levels; LUSC cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.18 0.37 4.69e-12 Motion sickness; LUSC cis rs72781680 0.848 rs72798057 chr2:23976731 T/C cg08917208 chr2:24149416 ATAD2B 0.87 9.67 0.47 1.19e-19 Lymphocyte counts; LUSC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg25036284 chr2:26402008 FAM59B -0.69 -9.73 -0.47 7.08e-20 Gut microbiome composition (summer); LUSC cis rs12594515 0.967 rs8039088 chr15:45990178 T/C cg01629716 chr15:45996671 NA 0.39 5.96 0.31 6.31e-9 Waist circumference;Weight; LUSC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg07701084 chr6:150067640 NUP43 0.47 7.11 0.36 7.04e-12 Lung cancer; LUSC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg06238570 chr21:40685208 BRWD1 0.48 7.49 0.38 6.36e-13 Cognitive function; LUSC cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg01973587 chr1:228161476 NA 0.44 8.04 0.4 1.62e-14 Diastolic blood pressure; LUSC cis rs10504229 0.679 rs16921683 chr8:58053270 T/C cg21724239 chr8:58056113 NA 0.56 6.66 0.34 1.13e-10 Developmental language disorder (linguistic errors); LUSC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg18758796 chr5:131593413 PDLIM4 0.34 5.83 0.3 1.31e-8 Blood metabolite levels; LUSC cis rs950776 0.616 rs6495307 chr15:78890321 C/T cg06917634 chr15:78832804 PSMA4 0.75 13.18 0.59 3.05e-32 Sudden cardiac arrest; LUSC cis rs1538970 0.924 rs10890327 chr1:45891458 C/T cg05343316 chr1:45956843 TESK2 0.65 8.88 0.44 4.17e-17 Platelet count; LUSC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.4 -5.93 -0.31 7.55e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg01579765 chr21:45077557 HSF2BP -0.55 -11.46 -0.53 7.13e-26 Mean corpuscular volume; LUSC cis rs1372520 0.745 rs2736994 chr4:90784528 A/G cg01966878 chr4:90757139 SNCA -0.42 -5.81 -0.3 1.43e-8 Neuroticism; LUSC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg05623727 chr3:50126028 RBM5 0.32 5.96 0.31 6.38e-9 Intelligence (multi-trait analysis); LUSC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg07256732 chr16:621771 PIGQ -0.35 -6.38 -0.33 5.75e-10 Height; LUSC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg05347473 chr6:146136440 FBXO30 0.54 9.03 0.44 1.44e-17 Lobe attachment (rater-scored or self-reported); LUSC cis rs7582720 0.943 rs72936839 chr2:203773237 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 8.42 0.42 1.16e-15 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs929354 0.772 rs2301916 chr7:156974127 G/T cg05182265 chr7:156933206 UBE3C -0.58 -9.27 -0.45 2.44e-18 Body mass index; LUSC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg06850241 chr22:41845214 NA 0.31 5.65 0.3 3.47e-8 Vitiligo; LUSC cis rs710216 0.957 rs859511 chr1:43430260 C/T cg22176566 chr1:43424700 SLC2A1 0.46 5.8 0.3 1.56e-8 Red cell distribution width; LUSC cis rs8060686 0.641 rs7188085 chr16:68113873 A/G cg05110241 chr16:68378359 PRMT7 -0.51 -5.99 -0.31 5.5e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs2835872 0.758 rs1709835 chr21:39037636 A/G cg20424643 chr21:39039972 KCNJ6 -0.44 -7.39 -0.37 1.18e-12 Electroencephalographic traits in alcoholism; LUSC cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.05 -0.36 1.06e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg21724239 chr8:58056113 NA 0.57 6.58 0.34 1.84e-10 Developmental language disorder (linguistic errors); LUSC cis rs9467773 0.529 rs7356988 chr6:26396727 G/T cg09904177 chr6:26538194 HMGN4 -0.53 -7.87 -0.4 4.98e-14 Intelligence (multi-trait analysis); LUSC cis rs644799 0.544 rs687559 chr11:95598629 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.6 -9.27 -0.45 2.33e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC trans rs3733585 0.664 rs17245436 chr4:9958169 A/G cg26043149 chr18:55253948 FECH -0.46 -7.05 -0.36 1.01e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs2285947 1.000 rs10228845 chr7:21583617 G/A cg04471919 chr7:21584483 DNAH11 0.34 7.61 0.38 2.86e-13 Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma); LUSC trans rs11250098 0.574 rs7015168 chr8:10772210 G/C cg15556689 chr8:8085844 FLJ10661 -0.55 -7.87 -0.4 4.88e-14 Morning vs. evening chronotype; LUSC cis rs5769765 0.632 rs13056783 chr22:50259152 A/T cg26441486 chr22:50317300 CRELD2 -0.54 -8.04 -0.4 1.59e-14 Schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg26494424 chr12:124118326 EIF2B1;GTF2H3 -0.53 -6.76 -0.35 6.3e-11 Bipolar disorder and schizophrenia; LUSC cis rs250677 0.652 rs1422582 chr5:148436925 T/C cg18129178 chr5:148520854 ABLIM3 -0.74 -10.19 -0.49 2.01e-21 Breast cancer; LUSC cis rs6754311 0.593 rs1438305 chr2:136502792 C/G cg07169764 chr2:136633963 MCM6 -0.6 -7.95 -0.4 2.88e-14 Mosquito bite size; LUSC cis rs6964587 0.839 rs13229273 chr7:91444472 G/A cg17063962 chr7:91808500 NA 0.56 8.54 0.42 4.84e-16 Breast cancer; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg12149777 chr4:139937459 CCRN4L -0.48 -6.55 -0.34 2.22e-10 Bipolar disorder and schizophrenia; LUSC cis rs17401966 0.522 rs7368073 chr1:10314962 G/T cg17425144 chr1:10567563 PEX14 -0.32 -5.67 -0.3 3.15e-8 Hepatocellular carcinoma; LUSC trans rs9329221 0.905 rs4610752 chr8:10248962 A/G cg15556689 chr8:8085844 FLJ10661 -0.61 -9.35 -0.46 1.3e-18 Neuroticism; LUSC cis rs2594989 0.943 rs9830784 chr3:11434605 A/G cg00170343 chr3:11313890 ATG7 0.52 5.88 0.31 9.99e-9 Circulating chemerin levels; LUSC cis rs13089785 0.791 rs16834826 chr3:123584488 C/T cg02012769 chr3:123398346 MYLK -0.33 -6.22 -0.32 1.5e-9 Intelligence (multi-trait analysis); LUSC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg04944784 chr2:26401820 FAM59B -0.68 -9.42 -0.46 7.58e-19 Gut microbiome composition (summer); LUSC cis rs977987 0.778 rs7203157 chr16:75417920 T/C cg04384234 chr16:75411784 CFDP1 -0.43 -7.2 -0.37 4.07e-12 Dupuytren's disease; LUSC cis rs17270561 0.608 rs4711102 chr6:25742075 T/C cg16482183 chr6:26056742 HIST1H1C 0.63 8.97 0.44 2.11e-17 Iron status biomarkers; LUSC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs7592578 0.581 rs59109438 chr2:191287683 A/G cg11845111 chr2:191398756 TMEM194B -0.81 -11.01 -0.52 2.86e-24 Diastolic blood pressure; LUSC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 8.7 0.43 1.59e-16 Age-related macular degeneration (geographic atrophy); LUSC cis rs7789940 1.000 rs76024966 chr7:75995021 C/T cg15798862 chr7:76129360 DTX2 -0.52 -8.58 -0.42 3.63e-16 Multiple sclerosis; LUSC cis rs4919087 0.884 rs4917762 chr10:98976471 G/T cg25902810 chr10:99078978 FRAT1 0.5 7.09 0.36 7.8e-12 Monocyte count; LUSC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg08859206 chr1:53392774 SCP2 -0.42 -6.76 -0.35 6.07e-11 Monocyte count; LUSC trans rs7824557 1.000 rs7824557 chr8:11104111 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -6.76 -0.35 6.23e-11 Retinal vascular caliber; LUSC cis rs10208940 0.920 rs10211211 chr2:68718191 G/C cg12452813 chr2:68675892 NA 0.58 5.95 0.31 6.61e-9 Urate levels in lean individuals; LUSC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg17330251 chr7:94953956 PON1 -0.37 -5.91 -0.31 8.61e-9 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg24130564 chr14:104152367 KLC1 -0.43 -5.78 -0.3 1.68e-8 Intelligence (multi-trait analysis); LUSC cis rs11122272 0.735 rs2486729 chr1:231535584 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -10.0 -0.48 9.09e-21 Hemoglobin concentration; LUSC cis rs134594 0.569 rs134559 chr22:29458441 C/T cg13586696 chr22:29458723 C22orf31 -0.39 -6.38 -0.33 5.75e-10 Birth weight; LUSC cis rs12575480 0.637 rs6578975 chr11:2095799 C/T cg15541987 chr11:2077307 NA 0.41 6.3 0.33 9.52e-10 Pursuit maintenance gain; LUSC cis rs12594515 1.000 rs8039622 chr15:45986431 A/G cg19682013 chr15:45996608 NA 0.39 5.9 0.31 8.82e-9 Waist circumference;Weight; LUSC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg13939156 chr17:80058883 NA 0.34 6.72 0.35 7.89e-11 Life satisfaction; LUSC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.28 0.49 1.06e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7582720 1.000 rs4675310 chr2:203880834 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.75 -7.84 -0.39 5.97e-14 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; LUSC cis rs7223966 1.000 rs61360320 chr17:61800392 C/T cg00945038 chr17:61921165 SMARCD2 0.4 6.09 0.32 3.17e-9 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.45 0.33 3.85e-10 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.05e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg24675658 chr1:53192096 ZYG11B 0.62 9.86 0.47 2.72e-20 Monocyte count; LUSC cis rs698813 0.572 rs12613771 chr2:44490660 C/A cg00619915 chr2:44497795 NA -0.53 -7.61 -0.38 2.83e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg08213375 chr14:104286397 PPP1R13B 0.52 10.14 0.49 3.02e-21 Schizophrenia; LUSC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg22834771 chr12:69754056 YEATS4 -0.49 -7.4 -0.38 1.14e-12 Blood protein levels; LUSC cis rs7929679 0.521 rs11032852 chr11:34788308 C/A cg06937548 chr11:34938143 PDHX;APIP 0.4 5.9 0.31 8.92e-9 Chronic obstructive pulmonary disease-related biomarkers;Lung disease severity in cystic fibrosis; LUSC cis rs35146811 0.695 rs1618851 chr7:99810643 T/G cg19116668 chr7:99932089 PMS2L1 0.35 6.12 0.32 2.68e-9 Coronary artery disease; LUSC cis rs8060686 0.623 rs2301814 chr16:68105171 C/G cg09835421 chr16:68378352 PRMT7 -0.45 -5.96 -0.31 6.35e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg26061582 chr7:22766209 IL6 0.48 7.09 0.36 8e-12 Lung cancer; LUSC cis rs12594515 0.967 rs8039088 chr15:45990178 T/C cg06207120 chr15:45996521 NA 0.39 5.99 0.31 5.51e-9 Waist circumference;Weight; LUSC cis rs7605827 0.897 rs1996518 chr2:15517419 A/G cg19274914 chr2:15703543 NA 0.45 8.73 0.43 1.27e-16 Educational attainment (years of education); LUSC cis rs7107174 1.000 rs2511187 chr11:77985849 T/A cg02023728 chr11:77925099 USP35 0.48 6.81 0.35 4.5e-11 Testicular germ cell tumor; LUSC cis rs2439831 0.850 rs3097773 chr15:43893072 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.67 -7.35 -0.37 1.49e-12 Lung cancer in ever smokers; LUSC cis rs9807841 0.568 rs1560707 chr19:10750738 A/C cg09936142 chr19:10668400 KRI1 -0.39 -6.18 -0.32 1.84e-9 Inflammatory skin disease; LUSC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg24879335 chr3:133465180 TF 0.46 7.91 0.4 3.69e-14 Iron status biomarkers (transferrin levels); LUSC cis rs7917772 0.560 rs729023 chr10:104341887 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.66 -10.83 -0.51 1.24e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg22920501 chr2:26401640 FAM59B -0.74 -10.51 -0.5 1.71e-22 Gut microbiome composition (summer); LUSC cis rs7089973 0.523 rs7071789 chr10:116735341 T/C cg23260525 chr10:116636907 FAM160B1 0.29 5.7 0.3 2.64e-8 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs1044826 0.913 rs9860521 chr3:139214559 A/G cg00490450 chr3:139108681 COPB2 0.51 6.8 0.35 4.8e-11 Obesity-related traits; LUSC trans rs72674100 1.000 rs13353562 chr4:97977235 T/C cg09670535 chr1:18959427 PAX7 -0.56 -5.98 -0.31 5.64e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs73198271 0.515 rs79282666 chr8:8638225 T/C cg01851573 chr8:8652454 MFHAS1 0.56 6.24 0.32 1.32e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs17034641 1.000 rs12990867 chr2:46372411 G/A cg12428440 chr2:46370979 PRKCE 0.44 5.92 0.31 8.03e-9 Hemoglobin;Hematocrit; LUSC cis rs11122272 0.735 rs2247132 chr1:231493359 G/A cg06096015 chr1:231504339 EGLN1 0.58 10.29 0.49 9.7e-22 Hemoglobin concentration; LUSC cis rs6582630 0.500 rs35251810 chr12:38577666 T/C cg26384229 chr12:38710491 ALG10B -0.55 -8.24 -0.41 3.89e-15 Drug-induced liver injury (flucloxacillin); LUSC trans rs853679 0.567 rs1005126 chr6:28367623 C/G cg06606381 chr12:133084897 FBRSL1 -0.43 -6.15 -0.32 2.15e-9 Depression; LUSC cis rs1790761 0.692 rs1269981 chr11:67334959 G/A cg24690094 chr11:67383802 NA 0.42 8.3 0.41 2.7e-15 Mean corpuscular volume; LUSC trans rs6561151 0.681 rs61959998 chr13:44462501 A/T cg12856521 chr11:46389249 DGKZ 0.78 9.71 0.47 8.39e-20 Crohn's disease; LUSC cis rs686320 1.000 rs3132770 chr11:65251317 G/A cg21890820 chr11:65308645 LTBP3 0.75 7.37 0.37 1.31e-12 Hip circumference adjusted for BMI; LUSC cis rs2224391 0.534 rs2753229 chr6:5246633 T/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.49 -6.74 -0.35 7e-11 Height; LUSC cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -7.04 -0.36 1.08e-11 Monocyte percentage of white cells; LUSC cis rs362296 0.698 rs362283 chr4:3259558 T/C cg14583973 chr4:3374767 RGS12 -0.31 -5.85 -0.3 1.19e-8 Parental longevity (mother's age at death); LUSC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg20821713 chr7:1055600 C7orf50 -0.45 -5.65 -0.3 3.52e-8 Bronchopulmonary dysplasia; LUSC trans rs3857536 0.813 rs7771569 chr6:66946717 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.44 -6.06 -0.31 3.62e-9 Blood trace element (Cu levels); LUSC cis rs380904 0.926 rs7842979 chr8:144601896 T/G cg20583945 chr8:144636462 GSDMD 0.44 5.79 0.3 1.62e-8 Venous thromboembolism (SNP x SNP interaction); LUSC cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg01483505 chr11:975446 AP2A2 0.42 6.01 0.31 4.75e-9 Alzheimer's disease (late onset); LUSC cis rs16910800 0.731 rs59333536 chr11:23191649 G/A cg20040320 chr11:23191996 NA -0.59 -7.63 -0.39 2.4e-13 Cancer; LUSC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -5.67 -0.3 3.14e-8 Developmental language disorder (linguistic errors); LUSC cis rs12586317 0.620 rs7147571 chr14:35530236 T/C cg16230307 chr14:35515116 FAM177A1 0.79 10.14 0.49 3.01e-21 Psoriasis; LUSC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg11764359 chr7:65958608 NA 0.81 13.64 0.6 5.83e-34 Aortic root size; LUSC cis rs9479482 1.000 rs9478362 chr6:150340526 T/C cg07578070 chr6:150326732 RAET1K 0.41 6.36 0.33 6.56e-10 Alopecia areata; LUSC cis rs73193808 0.614 rs2832251 chr21:30559552 G/C cg03476357 chr21:30257390 N6AMT1 0.45 6.05 0.31 3.96e-9 Coronary artery disease; LUSC cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -7.6 -0.38 2.97e-13 Bone mineral density; LUSC cis rs62400317 0.859 rs12209161 chr6:45104321 G/A cg20913747 chr6:44695427 NA -0.47 -7.5 -0.38 5.93e-13 Total body bone mineral density; LUSC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg02503808 chr4:7069936 GRPEL1 1.05 14.94 0.63 5.16e-39 Monocyte percentage of white cells; LUSC cis rs897080 0.515 rs698815 chr2:44706974 G/T cg00619915 chr2:44497795 NA -0.44 -6.4 -0.33 5.31e-10 Height; LUSC trans rs7618501 0.602 rs2013208 chr3:50129399 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.16 -0.45 5.28e-18 Intelligence (multi-trait analysis); LUSC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg12463550 chr7:65579703 CRCP -0.53 -7.73 -0.39 1.31e-13 Aortic root size; LUSC cis rs5758511 0.633 rs5758690 chr22:42668295 C/G cg00645731 chr22:42541494 CYP2D7P1 0.55 9.71 0.47 8.39e-20 Birth weight; LUSC cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.75 6.54 0.34 2.31e-10 Lung cancer in ever smokers; LUSC cis rs17253792 0.822 rs75999534 chr14:56036413 A/T cg01858014 chr14:56050164 KTN1 -0.89 -7.04 -0.36 1.1e-11 Putamen volume; LUSC cis rs7178572 0.568 rs4886866 chr15:77696166 A/T cg22256960 chr15:77711686 NA -0.49 -7.81 -0.39 7.66e-14 Type 2 diabetes; LUSC cis rs12681287 0.571 rs10097450 chr8:87358677 G/A cg27223183 chr8:87520930 FAM82B 0.55 7.37 0.37 1.34e-12 Caudate activity during reward; LUSC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg05082376 chr22:42548792 NA -0.42 -6.29 -0.33 1.01e-9 Schizophrenia; LUSC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.5 -0.34 2.87e-10 Lung cancer; LUSC cis rs950027 0.620 rs1426932 chr15:45687256 T/C cg21132104 chr15:45694354 SPATA5L1 0.42 6.14 0.32 2.4e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg19346786 chr7:2764209 NA -0.38 -6.55 -0.34 2.23e-10 Height; LUSC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg04414720 chr1:150670196 GOLPH3L 0.52 8.07 0.4 1.3e-14 Melanoma; LUSC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 8.46 0.42 8.63e-16 Prudent dietary pattern; LUSC cis rs4988958 0.548 rs6543127 chr2:103028301 A/C cg03938978 chr2:103052716 IL18RAP 0.37 7.08 0.36 8.72e-12 Asthma (childhood onset); LUSC trans rs2832191 0.740 rs2832175 chr21:30475606 A/G cg14791747 chr16:20752902 THUMPD1 0.42 6.31 0.33 9e-10 Dental caries; LUSC trans rs11250098 0.574 rs4240672 chr8:10767917 G/A cg15556689 chr8:8085844 FLJ10661 -0.56 -7.99 -0.4 2.16e-14 Morning vs. evening chronotype; LUSC cis rs6121246 0.865 rs77130187 chr20:30269060 G/A cg13852791 chr20:30311386 BCL2L1 0.92 11.23 0.52 5e-25 Mean corpuscular hemoglobin; LUSC cis rs7917772 0.582 rs10883736 chr10:104320029 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 11.17 0.52 7.7e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.57 0.42 3.81e-16 Menarche (age at onset); LUSC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs9473147 0.516 rs1931837 chr6:47442377 C/T cg20196966 chr6:47445060 CD2AP 0.41 5.66 0.3 3.28e-8 Platelet distribution width;Mean platelet volume; LUSC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg05855489 chr10:104503620 C10orf26 0.62 7.86 0.39 5.47e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs1474256 0.630 rs79015977 chr15:79450147 G/A cg17916960 chr15:79447300 NA 0.37 6.51 0.34 2.7e-10 Bronchopulmonary dysplasia; LUSC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -7.45 -0.38 8.01e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs4891159 0.790 rs689885 chr18:74110563 T/G cg24786174 chr18:74118243 ZNF516 0.81 14.91 0.63 6.76e-39 Longevity; LUSC cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs3809863 0.602 rs7225700 chr17:45391804 T/C cg25173405 chr17:45401733 C17orf57 -0.46 -6.7 -0.34 8.87e-11 Glaucoma (primary open-angle); LUSC trans rs7613875 0.620 rs3774734 chr3:50108792 C/A cg21659725 chr3:3221576 CRBN -0.53 -8.46 -0.42 8.77e-16 Body mass index; LUSC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg04025307 chr7:1156635 C7orf50 0.56 8.91 0.44 3.47e-17 Longevity;Endometriosis; LUSC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.37 -5.89 -0.31 9.63e-9 Alzheimer's disease (late onset); LUSC cis rs3018712 0.590 rs4930585 chr11:68411347 T/C cg20283391 chr11:68216788 NA 0.57 5.69 0.3 2.73e-8 Total body bone mineral density; LUSC cis rs6089584 0.566 rs6061964 chr20:60607536 G/A cg24733560 chr20:60626293 TAF4 0.44 8.09 0.4 1.15e-14 Body mass index; LUSC cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg21535247 chr6:8435926 SLC35B3 0.56 8.56 0.42 4.29e-16 Motion sickness; LUSC cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.65 0.86 4.24e-99 Chronic sinus infection; LUSC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg00864171 chr11:67383662 NA 0.4 7.15 0.36 5.56e-12 Mean corpuscular volume; LUSC cis rs6121246 0.529 rs58757492 chr20:30181425 G/A cg13852791 chr20:30311386 BCL2L1 0.71 8.05 0.4 1.49e-14 Mean corpuscular hemoglobin; LUSC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg12379764 chr21:47803548 PCNT -0.64 -8.86 -0.44 4.9e-17 Testicular germ cell tumor; LUSC cis rs10197940 0.624 rs10497082 chr2:152355258 T/C cg06191203 chr2:152266755 RIF1 -0.54 -7.28 -0.37 2.41e-12 Lung cancer; LUSC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg21918786 chr6:109611834 NA -0.37 -6.41 -0.33 4.89e-10 Reticulocyte fraction of red cells; LUSC cis rs1559088 1.000 rs12979164 chr19:33553228 G/C cg17764715 chr19:33622953 WDR88 0.58 7.95 0.4 2.98e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg03670158 chr17:41323431 NBR1 -0.44 -6.11 -0.32 2.79e-9 Hepatitis; LUSC cis rs1322512 0.874 rs2038619 chr6:152968787 G/A cg27316956 chr6:152958899 SYNE1 -0.37 -6.34 -0.33 7.62e-10 Tonometry; LUSC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg25456477 chr12:86230367 RASSF9 0.44 7.77 0.39 9.69e-14 Major depressive disorder; LUSC cis rs9400467 0.528 rs6933627 chr6:111600809 C/T cg22127309 chr6:111907043 TRAF3IP2 -0.35 -6.43 -0.33 4.38e-10 Blood metabolite levels;Amino acid levels; LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg16325326 chr1:53192061 ZYG11B 0.87 15.87 0.66 1.16e-42 Monocyte count; LUSC cis rs11585357 0.689 rs2977293 chr1:17599444 C/T cg08277548 chr1:17600880 PADI3 -0.45 -5.77 -0.3 1.86e-8 Hair shape; LUSC cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg04455712 chr21:45112962 RRP1B 0.46 8.62 0.43 2.69e-16 Mean corpuscular volume; LUSC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg27165867 chr14:105738592 BRF1 -0.53 -7.76 -0.39 1.06e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs11098499 0.754 rs4443261 chr4:120249301 T/C cg09307838 chr4:120376055 NA 0.69 10.41 0.49 3.68e-22 Corneal astigmatism; LUSC cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg26384229 chr12:38710491 ALG10B 0.9 15.63 0.65 1e-41 Drug-induced liver injury (flucloxacillin); LUSC cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg03676636 chr4:99064102 C4orf37 0.35 7.68 0.39 1.83e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs477692 1.000 rs538969 chr10:131410608 C/T cg11019008 chr10:131425282 MGMT 0.46 6.91 0.35 2.47e-11 Response to temozolomide; LUSC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.4 6.0 0.31 5.19e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg03526776 chr6:41159608 TREML2 0.33 6.19 0.32 1.74e-9 Alzheimer's disease (late onset); LUSC cis rs9910055 0.659 rs6503488 chr17:42246158 T/G cg13607699 chr17:42295918 UBTF 0.49 7.63 0.39 2.41e-13 Total body bone mineral density; LUSC cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 7.17 0.37 4.94e-12 Cognitive ability; LUSC cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg07606381 chr6:8435919 SLC35B3 0.73 12.46 0.56 1.62e-29 Motion sickness; LUSC cis rs7267979 1.000 rs2257991 chr20:25270339 C/T cg08601574 chr20:25228251 PYGB -0.42 -6.44 -0.33 4.23e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg09491104 chr22:46646882 C22orf40 -0.72 -6.91 -0.35 2.51e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs2280018 0.581 rs7404524 chr16:15129158 A/G cg07549590 chr16:15018862 NA -0.47 -7.65 -0.39 2.13e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs2290416 0.892 rs62522165 chr8:144675379 C/T cg08017634 chr8:144659831 NAPRT1 0.7 6.06 0.31 3.64e-9 Attention deficit hyperactivity disorder; LUSC cis rs9650315 0.810 rs13279155 chr8:57202446 A/T cg23139584 chr8:56987506 RPS20;SNORD54 -0.54 -6.72 -0.35 7.8e-11 Height; LUSC cis rs11098499 0.562 rs58583086 chr4:120556362 A/G cg09307838 chr4:120376055 NA -0.59 -9.17 -0.45 4.95e-18 Corneal astigmatism; LUSC cis rs12681287 0.752 rs10956786 chr8:87301237 T/C cg27223183 chr8:87520930 FAM82B -0.45 -5.73 -0.3 2.29e-8 Caudate activity during reward; LUSC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg23985595 chr17:80112537 CCDC57 -0.32 -6.28 -0.33 1.04e-9 Life satisfaction; LUSC cis rs2455601 0.882 rs10840139 chr11:8894838 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -7.21 -0.37 3.7e-12 Schizophrenia; LUSC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg00290607 chr11:67383545 NA 0.47 9.39 0.46 9.78e-19 Mean corpuscular volume; LUSC cis rs4704187 0.687 rs4345300 chr5:74376571 C/T cg03227963 chr5:74354835 NA 0.31 6.73 0.35 7.4e-11 Response to amphetamines; LUSC cis rs6964587 1.000 rs57816416 chr7:91736078 A/C cg17063962 chr7:91808500 NA 0.6 9.36 0.46 1.17e-18 Breast cancer; LUSC cis rs8078723 1.000 rs8078723 chr17:38166879 A/G cg17467752 chr17:38218738 THRA 0.77 12.59 0.57 5.34e-30 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2625529 0.617 rs2415120 chr15:72105544 A/G cg16672083 chr15:72433130 SENP8 -0.47 -7.67 -0.39 1.94e-13 Red blood cell count; LUSC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg07701084 chr6:150067640 NUP43 0.51 7.78 0.39 8.9e-14 Lung cancer; LUSC cis rs10089 1.000 rs4836360 chr5:127458161 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 11.87 0.54 2.31e-27 Ileal carcinoids; LUSC cis rs478304 0.903 rs61895677 chr11:65549415 T/C cg27068330 chr11:65405492 SIPA1 0.65 9.82 0.47 3.71e-20 Acne (severe); LUSC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg10802521 chr3:52805072 NEK4 -0.56 -8.8 -0.43 7.57e-17 Bipolar disorder; LUSC cis rs6733011 0.582 rs2280256 chr2:99449174 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.45 -6.52 -0.34 2.65e-10 Bipolar disorder; LUSC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg20684491 chr1:25596433 NA 0.41 6.66 0.34 1.1e-10 Erythrocyte sedimentation rate; LUSC cis rs5760092 0.627 rs6519489 chr22:24261846 G/A cg01238044 chr22:24384105 GSTT1 0.59 7.23 0.37 3.34e-12 Urinary 1,3-butadiene metabolite levels in smokers; LUSC cis rs1215050 0.791 rs684210 chr4:98678740 G/C cg05340658 chr4:99064831 C4orf37 0.46 7.28 0.37 2.39e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6977940 0.643 rs73033417 chr7:2882855 C/G cg19346786 chr7:2764209 NA 0.52 5.73 0.3 2.29e-8 White matter integrity; LUSC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg20608306 chr11:116969690 SIK3 0.34 6.33 0.33 7.99e-10 Blood protein levels; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg20264529 chr10:30638039 MTPAP -0.44 -6.4 -0.33 5.37e-10 Electrocardiographic conduction measures; LUSC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg19592336 chr6:28129416 ZNF389 0.47 6.04 0.31 4.21e-9 Depression; LUSC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg02269571 chr22:50332266 NA -0.57 -8.51 -0.42 6.17e-16 Schizophrenia; LUSC cis rs9296092 0.560 rs62407569 chr6:33538865 A/G cg13560919 chr6:33536144 NA -0.85 -16.25 -0.66 3.53e-44 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs79149102 0.579 rs6495146 chr15:75367630 A/T cg09165964 chr15:75287851 SCAMP5 -0.73 -6.56 -0.34 2.01e-10 Lung cancer; LUSC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg18681998 chr4:17616180 MED28 0.9 17.84 0.7 1.85e-50 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs11971779 0.680 rs11764236 chr7:139118514 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.16 0.36 5.18e-12 Diisocyanate-induced asthma; LUSC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg17554472 chr22:41940697 POLR3H -0.49 -5.86 -0.31 1.14e-8 Vitiligo; LUSC cis rs11785693 0.862 rs73183633 chr8:4994543 G/A cg26367366 chr8:4980734 NA 0.74 8.82 0.43 6.57e-17 Neuroticism (multi-trait analysis);Neuroticism; LUSC cis rs34638657 0.872 rs2967326 chr16:82188246 A/G cg09439754 chr16:82129088 HSD17B2 -0.41 -6.62 -0.34 1.47e-10 Lung adenocarcinoma; LUSC cis rs11190604 0.943 rs9420792 chr10:102258439 C/T cg23241863 chr10:102295624 HIF1AN 0.47 5.65 0.3 3.46e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9640161 0.830 rs1051823 chr7:150070814 G/A cg10018233 chr7:150070692 REPIN1 0.45 9.1 0.45 8.6e-18 Blood protein levels;Circulating chemerin levels; LUSC cis rs589691 0.502 rs487662 chr11:64481880 G/A cg19131476 chr11:64387923 NRXN2 -0.35 -8.3 -0.41 2.63e-15 Urate levels; LUSC trans rs4252134 0.881 rs4252107 chr6:161137518 T/C cg07697006 chr5:132202367 UQCRQ -0.42 -5.95 -0.31 6.95e-9 Giant cell arteritis; LUSC cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg24596788 chr1:163392923 NA -0.45 -7.49 -0.38 6.31e-13 Motion sickness; LUSC cis rs2153535 0.935 rs11243254 chr6:8381242 C/T cg21535247 chr6:8435926 SLC35B3 -0.46 -6.66 -0.34 1.13e-10 Motion sickness; LUSC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg27494647 chr7:150038898 RARRES2 -0.45 -6.79 -0.35 5.25e-11 Blood protein levels;Circulating chemerin levels; LUSC trans rs60843830 0.508 rs300750 chr2:208794 T/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.41 6.55 0.34 2.23e-10 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs6700896 0.966 rs7542446 chr1:66091106 G/A cg04111102 chr1:66153794 NA 0.32 7.02 0.36 1.23e-11 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg26695010 chr11:65641043 EFEMP2 -0.46 -7.05 -0.36 1.04e-11 Sum eosinophil basophil counts;Eosinophil counts; LUSC cis rs7712401 0.562 rs384483 chr5:122261573 G/T cg19077854 chr5:122220652 SNX24 -0.39 -8.39 -0.42 1.41e-15 Mean platelet volume; LUSC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.63 -0.39 2.52e-13 Developmental language disorder (linguistic errors); LUSC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg04317338 chr11:64019027 PLCB3 0.66 7.53 0.38 4.65e-13 Mean platelet volume; LUSC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg23172400 chr8:95962367 TP53INP1 -0.43 -8.96 -0.44 2.27e-17 Type 2 diabetes; LUSC cis rs1395 0.778 rs6749393 chr2:27451000 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.2 0.37 4.13e-12 Blood metabolite levels; LUSC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg19622623 chr12:86230825 RASSF9 0.4 5.75 0.3 2.02e-8 Major depressive disorder; LUSC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg02825527 chr7:2087843 MAD1L1 -0.48 -5.87 -0.31 1.07e-8 Bipolar disorder; LUSC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg06671706 chr8:8559999 CLDN23 0.48 6.52 0.34 2.65e-10 Obesity-related traits; LUSC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg24154853 chr7:158122151 PTPRN2 0.44 8.48 0.42 7.5e-16 Calcium levels; LUSC cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg26384229 chr12:38710491 ALG10B 0.89 15.26 0.64 2.9e-40 Drug-induced liver injury (flucloxacillin); LUSC cis rs7945705 0.818 rs10769948 chr11:8761782 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.37 -7.44 -0.38 8.46e-13 Hemoglobin concentration; LUSC cis rs965513 1.000 rs7030256 chr9:100535203 C/G cg13688889 chr9:100608707 NA -0.58 -8.65 -0.43 2.23e-16 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC cis rs854765 0.583 rs8073001 chr17:17831716 A/C cg04398451 chr17:18023971 MYO15A 0.5 8.08 0.4 1.18e-14 Total body bone mineral density; LUSC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg02503808 chr4:7069936 GRPEL1 -0.99 -11.91 -0.55 1.64e-27 Monocyte percentage of white cells; LUSC cis rs7215564 0.908 rs7501497 chr17:78660738 T/C cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs6494488 0.500 rs66500186 chr15:65002594 A/G cg08069370 chr15:64387884 SNX1 -0.61 -5.75 -0.3 1.98e-8 Coronary artery disease; LUSC cis rs2952768 0.965 rs2254137 chr2:208444028 C/A cg22739477 chr2:208394512 CREB1 0.34 5.66 0.3 3.24e-8 Opioid sensitivity; LUSC trans rs2587949 0.593 rs795288 chr3:4204455 T/C cg15139668 chr4:4577005 NA -0.41 -6.12 -0.32 2.68e-9 Periodontitis (DPAL); LUSC cis rs11190604 1.000 rs11190592 chr10:102291059 T/C cg07080220 chr10:102295463 HIF1AN 0.7 9.4 0.46 8.73e-19 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4474465 1.000 rs10899534 chr11:78210502 G/C cg27205649 chr11:78285834 NARS2 0.49 5.73 0.3 2.29e-8 Alzheimer's disease (survival time); LUSC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg18306943 chr3:40428807 ENTPD3 0.38 5.74 0.3 2.09e-8 Renal cell carcinoma; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg02951883 chr7:2050386 MAD1L1 -0.46 -8.12 -0.41 9.03e-15 Bipolar disorder and schizophrenia; LUSC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg05623727 chr3:50126028 RBM5 0.34 6.32 0.33 8.47e-10 Body mass index; LUSC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg22467129 chr15:76604101 ETFA -0.44 -6.95 -0.36 1.96e-11 Blood metabolite levels; LUSC cis rs9326248 0.559 rs482371 chr11:116752163 T/C cg26566898 chr11:117069891 TAGLN 0.37 7.0 0.36 1.37e-11 Blood protein levels; LUSC cis rs9473147 0.543 rs9369716 chr6:47552180 A/T cg12968598 chr6:47444699 CD2AP 0.52 7.95 0.4 2.91e-14 Platelet distribution width;Mean platelet volume; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg16845172 chr2:240425983 NA 0.46 6.31 0.33 9.01e-10 Neuroticism; LUSC cis rs12478296 1.000 rs11899408 chr2:243014630 A/G cg06360820 chr2:242988706 NA -0.89 -10.2 -0.49 1.88e-21 Obesity-related traits; LUSC cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.51 -0.38 5.3e-13 Morning vs. evening chronotype; LUSC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg10862848 chr6:42927986 GNMT -0.28 -6.73 -0.35 7.35e-11 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09678228 chr12:44230058 TMEM117 -0.4 -6.12 -0.32 2.68e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs926392 0.640 rs62202616 chr20:37692775 G/C cg16355469 chr20:37678765 NA 0.5 6.58 0.34 1.79e-10 Dialysis-related mortality; LUSC cis rs1395 0.744 rs11679220 chr2:27476378 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.48 7.22 0.37 3.53e-12 Blood metabolite levels; LUSC cis rs1018836 0.923 rs4735256 chr8:91612145 C/G cg16814680 chr8:91681699 NA -0.77 -12.92 -0.58 3.07e-31 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg25427524 chr10:38739819 LOC399744 -0.66 -11.9 -0.55 1.77e-27 Extrinsic epigenetic age acceleration; LUSC cis rs79349575 0.783 rs12602933 chr17:47029280 G/C cg22482690 chr17:47019901 SNF8 0.38 7.14 0.36 5.76e-12 Type 2 diabetes; LUSC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11890956 chr21:40555474 PSMG1 -0.71 -11.04 -0.52 2.36e-24 Menarche (age at onset); LUSC cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg27170947 chr2:26402098 FAM59B 0.72 10.77 0.51 2.12e-23 Gut microbiome composition (summer); LUSC cis rs9549260 0.712 rs9532564 chr13:41160579 C/G cg21288729 chr13:41239152 FOXO1 0.57 6.16 0.32 2.14e-9 Red blood cell count; LUSC trans rs3736485 0.903 rs8039835 chr15:51865864 A/G cg09125779 chr4:57547999 HOPX 0.34 6.01 0.31 4.85e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2455601 0.786 rs10279 chr11:8969309 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.46 -7.81 -0.39 7.69e-14 Schizophrenia; LUSC cis rs4680 0.712 rs740601 chr22:19950763 T/G cg22546130 chr22:19950026 COMT -0.39 -8.42 -0.42 1.1e-15 Blood metabolite levels; LUSC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg18252515 chr7:66147081 NA -1.2 -13.15 -0.58 4.19e-32 Diabetic kidney disease; LUSC cis rs6582630 0.539 rs12308081 chr12:38342881 C/G cg13010199 chr12:38710504 ALG10B -0.43 -6.32 -0.33 8.6e-10 Drug-induced liver injury (flucloxacillin); LUSC cis rs6542838 0.641 rs12712042 chr2:99534401 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -5.99 -0.31 5.55e-9 Fear of minor pain; LUSC cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg06784218 chr1:46089804 CCDC17 0.55 11.09 0.52 1.49e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs13202913 0.837 rs6906678 chr6:151772395 A/T cg10883421 chr6:151773342 RMND1;C6orf211 0.64 6.02 0.31 4.71e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; LUSC cis rs354225 0.544 rs11892443 chr2:54805776 A/G cg01766943 chr2:54829624 SPTBN1 0.48 7.61 0.38 2.89e-13 Schizophrenia; LUSC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg05340658 chr4:99064831 C4orf37 0.66 11.12 0.52 1.17e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -7.06 -0.36 9.61e-12 Psoriasis; LUSC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 13.46 0.59 2.67e-33 Alzheimer's disease; LUSC cis rs8114671 0.836 rs3746432 chr20:33592763 C/T cg24642439 chr20:33292090 TP53INP2 -0.39 -5.67 -0.3 3.12e-8 Height; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg12929040 chr8:56792373 LYN 0.43 6.39 0.33 5.47e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7904368 0.568 rs7075036 chr10:16864810 C/T cg23933602 chr10:16859644 RSU1 0.77 12.6 0.57 4.86e-30 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; LUSC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.45 7.14 0.36 5.9e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg24562669 chr7:97807699 LMTK2 0.37 6.36 0.33 6.72e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg03351412 chr1:154909251 PMVK 0.48 7.43 0.38 8.96e-13 Prostate cancer; LUSC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg25288140 chr17:41278341 BRCA1;NBR2 0.39 5.78 0.3 1.74e-8 Menopause (age at onset); LUSC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg05347473 chr6:146136440 FBXO30 -0.57 -9.85 -0.47 2.97e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg13560548 chr3:10150139 C3orf24 0.49 6.89 0.35 2.82e-11 Alzheimer's disease; LUSC cis rs2625529 0.730 rs2957373 chr15:72340929 T/C cg16672083 chr15:72433130 SENP8 0.5 8.01 0.4 1.87e-14 Red blood cell count; LUSC cis rs2979489 0.891 rs17551512 chr8:30330109 A/G cg26383811 chr8:30366931 RBPMS -0.51 -8.08 -0.4 1.23e-14 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; LUSC cis rs929354 0.772 rs7778193 chr7:156980087 C/T cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC trans rs1459104 0.925 rs12577653 chr11:55077102 G/A cg15704280 chr7:45808275 SEPT13 0.75 6.18 0.32 1.92e-9 Body mass index; LUSC cis rs7107174 0.711 rs66583694 chr11:78037773 C/T cg02023728 chr11:77925099 USP35 0.45 6.83 0.35 4.05e-11 Testicular germ cell tumor; LUSC cis rs7937682 0.924 rs875258 chr11:111530607 C/A cg09085632 chr11:111637200 PPP2R1B -1.1 -17.98 -0.7 4.8e-51 Primary sclerosing cholangitis; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg21908638 chr3:101497982 FAM55C -0.44 -6.45 -0.33 4.04e-10 Electrocardiographic conduction measures; LUSC cis rs2739330 0.732 rs5760175 chr22:24399655 T/G cg12419862 chr22:24373484 LOC391322 -1.04 -21.46 -0.76 8.36e-65 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7953508 0.711 rs3825199 chr12:93976954 A/G cg18151635 chr12:93972918 NA -0.56 -7.93 -0.4 3.26e-14 Pubertal anthropometrics; LUSC cis rs59104589 0.521 rs62190414 chr2:242424687 A/G cg19488206 chr2:242435732 STK25 0.37 5.65 0.3 3.49e-8 Fibrinogen levels; LUSC cis rs10876993 0.890 rs774891 chr12:58068571 G/A cg15848620 chr12:58087721 OS9 -0.54 -7.81 -0.39 7.51e-14 Celiac disease or Rheumatoid arthritis; LUSC cis rs1957429 0.808 rs6573580 chr14:65331766 C/G cg23373153 chr14:65346875 NA 0.95 10.83 0.51 1.25e-23 Pediatric areal bone mineral density (radius); LUSC cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg03146154 chr1:46216737 IPP 0.5 7.14 0.36 5.83e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs56283067 0.887 rs9472365 chr6:44770214 C/G cg20913747 chr6:44695427 NA 0.43 6.73 0.35 7.25e-11 Total body bone mineral density; LUSC cis rs2078087 0.522 rs2105160 chr1:183226129 G/C cg13843938 chr1:183241246 NMNAT2 0.38 6.31 0.33 9e-10 Obesity-related traits; LUSC cis rs6681460 0.800 rs485543 chr1:67194372 C/T cg02459107 chr1:67143332 SGIP1 -0.46 -8.37 -0.42 1.59e-15 Presence of antiphospholipid antibodies; LUSC cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg19196401 chr6:110721138 DDO -0.45 -8.46 -0.42 8.59e-16 Platelet distribution width; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg02678013 chr4:25378485 ANAPC4 0.4 6.28 0.32 1.05e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.99 0.31 5.3e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7927771 0.524 rs7929014 chr11:47776283 C/T cg20307385 chr11:47447363 PSMC3 0.44 6.44 0.33 4.18e-10 Subjective well-being; LUSC trans rs10982256 0.870 rs1408525 chr9:117274994 C/T cg03506640 chr14:85997753 FLRT2 -0.35 -5.95 -0.31 6.65e-9 Bipolar disorder; LUSC trans rs6600671 1.000 rs4844380 chr1:121193620 A/T cg00646200 chr1:148855367 NA 0.47 7.37 0.37 1.34e-12 Hip geometry; LUSC cis rs3768617 0.510 rs10752899 chr1:183081241 T/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.84 0.51 1.15e-23 Fuchs's corneal dystrophy; LUSC cis rs1865760 1.000 rs7757666 chr6:25902626 T/C cg16482183 chr6:26056742 HIST1H1C 0.44 6.53 0.34 2.43e-10 Height; LUSC cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg11584989 chr19:19387371 SF4 -0.53 -6.3 -0.33 9.52e-10 Bipolar disorder; LUSC cis rs4363385 0.818 rs3795381 chr1:153004848 T/C cg00922841 chr1:152955080 SPRR1A -0.41 -7.22 -0.37 3.42e-12 Inflammatory skin disease; LUSC cis rs6582630 0.537 rs8189533 chr12:38391068 A/G cg13010199 chr12:38710504 ALG10B 0.66 10.18 0.49 2.22e-21 Drug-induced liver injury (flucloxacillin); LUSC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg14552801 chr7:65878734 NA -0.46 -6.53 -0.34 2.45e-10 Aortic root size; LUSC cis rs7937682 0.602 rs4936804 chr11:111743851 A/C cg09085632 chr11:111637200 PPP2R1B 0.96 13.28 0.59 1.29e-32 Primary sclerosing cholangitis; LUSC trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg27661571 chr11:113659931 NA -0.71 -8.0 -0.4 2.07e-14 Hip circumference adjusted for BMI; LUSC cis rs12618769 1.000 rs12618769 chr2:99239931 A/G cg10123293 chr2:99228465 UNC50 -0.41 -5.87 -0.31 1.05e-8 Bipolar disorder; LUSC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.29 5.72 0.3 2.33e-8 Lymphocyte counts; LUSC cis rs9283706 0.607 rs10471696 chr5:66304823 T/C cg11590213 chr5:66331682 MAST4 0.45 6.72 0.34 8.08e-11 Coronary artery disease; LUSC cis rs4363385 0.588 rs11205180 chr1:153022070 A/G cg25856811 chr1:152973957 SPRR3 -0.36 -6.0 -0.31 5.04e-9 Inflammatory skin disease; LUSC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg25072359 chr17:41440525 NA 0.62 9.36 0.46 1.2e-18 Menopause (age at onset); LUSC trans rs17685 0.743 rs10277259 chr7:75802674 A/C cg19862616 chr7:65841803 NCRNA00174 1.12 19.01 0.72 3.91e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg13206674 chr6:150067644 NUP43 0.55 8.04 0.4 1.57e-14 Lung cancer; LUSC trans rs11098499 0.954 rs35063680 chr4:120387102 T/C cg25214090 chr10:38739885 LOC399744 0.57 8.42 0.42 1.1e-15 Corneal astigmatism; LUSC cis rs12579753 1.000 rs2400979 chr12:82197353 T/C cg21231944 chr12:82153410 PPFIA2 -0.38 -5.85 -0.3 1.15e-8 Resting heart rate; LUSC cis rs68170813 0.617 rs117884147 chr7:107177593 T/C cg02696742 chr7:106810147 HBP1 -0.64 -8.63 -0.43 2.46e-16 Coronary artery disease; LUSC cis rs644799 0.562 rs1313288 chr11:95520695 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.67 9.83 0.47 3.46e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs1801251 1.000 rs12478564 chr2:233598340 C/T cg08000102 chr2:233561755 GIGYF2 0.68 11.42 0.53 9.96e-26 Coronary artery disease; LUSC trans rs1997103 1.000 rs10228182 chr7:55406695 A/T cg20935933 chr6:143382018 AIG1 0.51 7.44 0.38 8.66e-13 QRS interval (sulfonylurea treatment interaction); LUSC trans rs6601327 0.898 rs1458942 chr8:9406602 C/T cg15556689 chr8:8085844 FLJ10661 -0.45 -6.09 -0.32 3.04e-9 Multiple myeloma (hyperdiploidy); LUSC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.39 -5.71 -0.3 2.47e-8 Extrinsic epigenetic age acceleration; LUSC cis rs2303759 0.914 rs2288481 chr19:49878196 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.58 7.13 0.36 6.19e-12 Multiple sclerosis; LUSC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.53 7.78 0.39 9.04e-14 Gut microbiome composition (summer); LUSC cis rs2050392 0.789 rs303438 chr10:30733493 C/T cg18806716 chr10:30721971 MAP3K8 0.53 8.74 0.43 1.12e-16 Inflammatory bowel disease; LUSC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg05347473 chr6:146136440 FBXO30 -0.57 -9.86 -0.47 2.71e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs854765 0.583 rs4925126 chr17:17798633 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.75 13.51 0.59 1.77e-33 Total body bone mineral density; LUSC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg17968037 chr7:100024898 ZCWPW1 -0.38 -5.79 -0.3 1.64e-8 Platelet count; LUSC cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg13057898 chr1:3703894 LRRC47 0.52 9.11 0.45 7.57e-18 Red cell distribution width; LUSC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg06008330 chr7:65541103 ASL 0.41 6.32 0.33 8.55e-10 Aortic root size; LUSC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg27170947 chr2:26402098 FAM59B -0.64 -9.42 -0.46 7.74e-19 Gut microbiome composition (summer); LUSC cis rs12748961 0.557 rs823127 chr1:205713139 G/A cg23034840 chr1:205782522 SLC41A1 0.51 5.9 0.31 8.76e-9 White blood cell types; LUSC cis rs66887589 0.775 rs6843229 chr4:120424087 T/C cg09307838 chr4:120376055 NA 0.5 7.54 0.38 4.45e-13 Diastolic blood pressure; LUSC cis rs997295 0.520 rs4776971 chr15:68081097 C/A cg08079166 chr15:68083412 MAP2K5 0.37 7.83 0.39 6.52e-14 Motion sickness; LUSC cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg13319975 chr6:146136371 FBXO30 -0.47 -6.84 -0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); LUSC trans rs4733781 1.000 rs4733781 chr8:131296767 A/C cg18393173 chr6:34856135 ANKS1A;TAF11 0.37 6.44 0.33 4.23e-10 Tuberculosis; LUSC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg17971929 chr21:40555470 PSMG1 -0.5 -7.38 -0.37 1.24e-12 Menarche (age at onset); LUSC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg17800788 chr1:21766015 NBPF3 0.32 6.13 0.32 2.43e-9 Liver enzyme levels (alkaline phosphatase); LUSC cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -9.36 -0.46 1.24e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg07425625 chr1:1243562 PUSL1;ACAP3 -0.42 -6.38 -0.33 5.97e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4253772 0.938 rs41378347 chr22:46636976 G/A cg18190219 chr22:46762943 CELSR1 -0.47 -5.73 -0.3 2.28e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs710865 0.527 rs2275403 chr1:19557713 C/G cg13387374 chr1:19411106 UBR4 -0.6 -9.87 -0.48 2.46e-20 Brain structure; LUSC cis rs1419980 0.630 rs2080126 chr12:7774524 A/C cg25828445 chr12:7781288 NA 0.62 6.59 0.34 1.67e-10 HDL cholesterol levels; LUSC cis rs11190604 1.000 rs12354411 chr10:102294537 G/A cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.24e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg07507251 chr3:52567010 NT5DC2 0.32 6.16 0.32 2.13e-9 Bipolar disorder; LUSC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg22920501 chr2:26401640 FAM59B -0.75 -11.39 -0.53 1.33e-25 Gut microbiome composition (summer); LUSC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg10117171 chr1:25599238 RHD -0.41 -6.22 -0.32 1.47e-9 Erythrocyte sedimentation rate; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18973632 chr17:36886646 CISD3 -0.41 -6.04 -0.31 4.07e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6686643 1.000 rs959617 chr1:165616881 C/G cg16553119 chr1:165599451 MGST3 -0.44 -6.68 -0.34 9.8e-11 Total ventricular volume; LUSC cis rs77741769 0.534 rs58918988 chr12:121332953 G/A cg02419362 chr12:121203948 SPPL3 0.46 8.51 0.42 6.09e-16 Mean corpuscular volume; LUSC cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg22117172 chr7:91764530 CYP51A1 0.32 5.82 0.3 1.36e-8 Breast cancer; LUSC cis rs4478858 0.647 rs10798835 chr1:31709055 T/C cg00250761 chr1:31883323 NA -0.34 -8.26 -0.41 3.37e-15 Alcohol dependence; LUSC cis rs2274273 0.662 rs67215571 chr14:55673723 G/A cg04306507 chr14:55594613 LGALS3 0.47 9.24 0.45 3.04e-18 Protein biomarker; LUSC cis rs6087990 0.806 rs910084 chr20:31379665 C/T cg13636640 chr20:31349939 DNMT3B 0.87 17.46 0.69 6.03e-49 Ulcerative colitis; LUSC cis rs16854884 0.632 rs34038325 chr3:143685097 G/A cg06585982 chr3:143692056 C3orf58 0.45 6.83 0.35 4.09e-11 Economic and political preferences (feminism/equality); LUSC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg17507749 chr15:85114479 UBE2QP1 0.67 8.48 0.42 7.14e-16 Schizophrenia; LUSC cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg06064525 chr11:970664 AP2A2 -0.49 -10.82 -0.51 1.42e-23 Alzheimer's disease (late onset); LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg24449302 chr15:66679100 MAP2K1 -0.36 -6.65 -0.34 1.18e-10 Electrocardiographic conduction measures; LUSC cis rs250677 0.958 rs43147 chr5:148417103 C/G cg23229984 chr5:148520753 ABLIM3 -0.38 -6.1 -0.32 2.88e-9 Breast cancer; LUSC cis rs4253772 0.513 rs11090863 chr22:46705407 C/T cg00784671 chr22:46762841 CELSR1 -0.52 -6.59 -0.34 1.69e-10 LDL cholesterol;Cholesterol, total; LUSC cis rs13315871 0.929 rs35004361 chr3:58313394 T/C cg12435725 chr3:58293450 RPP14 -0.7 -7.23 -0.37 3.21e-12 Cholesterol, total; LUSC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg14552801 chr7:65878734 NA 0.37 5.7 0.3 2.7e-8 Aortic root size; LUSC cis rs7799006 0.722 rs33981648 chr7:2288669 T/C cg08027265 chr7:2291960 NA -0.64 -11.68 -0.54 1.17e-26 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7824557 0.628 rs11994376 chr8:11202960 G/A cg21293242 chr8:11204541 TDH 0.32 5.85 0.3 1.15e-8 Retinal vascular caliber; LUSC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg03352830 chr11:487213 PTDSS2 0.68 8.57 0.42 3.96e-16 Body mass index; LUSC cis rs17270561 0.609 rs4711095 chr6:25726774 A/C cg16482183 chr6:26056742 HIST1H1C 0.65 9.13 0.45 6.68e-18 Iron status biomarkers; LUSC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs929354 0.772 rs933344 chr7:157011265 A/T cg17757837 chr7:157058334 UBE3C 0.81 13.1 0.58 6.53e-32 Body mass index; LUSC cis rs7481584 0.517 rs80872 chr11:3049984 G/T cg08508325 chr11:3079039 CARS 0.38 8.45 0.42 9.13e-16 Calcium levels; LUSC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg05368731 chr17:41323189 NBR1 0.92 15.51 0.65 2.94e-41 Menopause (age at onset); LUSC cis rs7760949 0.888 rs1966191 chr6:13911961 A/C cg27413430 chr6:13925136 RNF182 0.48 7.01 0.36 1.31e-11 Mean corpuscular hemoglobin concentration; LUSC trans rs3942852 0.955 rs6485809 chr11:48112468 C/T cg03929089 chr4:120376271 NA -0.54 -6.21 -0.32 1.58e-9 Acute lymphoblastic leukemia (childhood); LUSC trans rs9929218 0.608 rs35158985 chr16:68796746 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.69 -10.35 -0.49 5.93e-22 Colorectal cancer; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg09131844 chr2:27651398 NRBP1 0.41 6.21 0.32 1.58e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs2932538 0.922 rs2932535 chr1:113201412 G/C cg22162597 chr1:113214053 CAPZA1 -0.67 -9.72 -0.47 7.69e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg12667521 chr19:29218732 NA 0.61 7.51 0.38 5.53e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); LUSC cis rs7112043 0.778 rs1472975 chr11:34776643 T/C cg06937548 chr11:34938143 PDHX;APIP 0.4 5.74 0.3 2.08e-8 Lung disease severity in cystic fibrosis; LUSC cis rs11098499 0.722 rs10025925 chr4:120271744 A/T cg24375607 chr4:120327624 NA 0.67 10.54 0.5 1.33e-22 Corneal astigmatism; LUSC cis rs7177699 0.557 rs4433781 chr15:79121835 A/T cg15571903 chr15:79123663 NA -0.35 -6.4 -0.33 5.3e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg21918786 chr6:109611834 NA -0.36 -6.25 -0.32 1.25e-9 Reticulocyte fraction of red cells; LUSC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg04369109 chr6:150039330 LATS1 -0.58 -8.43 -0.42 1.02e-15 Lung cancer; LUSC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg22823121 chr1:150693482 HORMAD1 0.5 7.32 0.37 1.85e-12 Melanoma; LUSC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg05084668 chr3:125655381 ALG1L -0.47 -6.65 -0.34 1.22e-10 Blood pressure (smoking interaction); LUSC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg05347473 chr6:146136440 FBXO30 -0.55 -9.61 -0.47 1.89e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.4 5.75 0.3 2e-8 Tonsillectomy; LUSC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg17178900 chr1:205818956 PM20D1 0.8 13.41 0.59 4.19e-33 Menarche (age at onset); LUSC cis rs751728 0.687 rs943479 chr6:33752013 A/G cg25922239 chr6:33757077 LEMD2 0.42 6.37 0.33 6.27e-10 Crohn's disease; LUSC cis rs6430585 0.528 rs115553816 chr2:136692893 G/A cg07169764 chr2:136633963 MCM6 1.13 17.16 0.68 8.74e-48 Corneal structure; LUSC cis rs238295 0.805 rs1056244 chr20:5551034 G/C cg15842884 chr20:5591925 RP5-1022P6.2 -0.43 -5.87 -0.31 1.07e-8 Occipital cortical area (total cortical area interaction); LUSC cis rs10848704 0.637 rs11062351 chr12:2881763 C/T cg19995117 chr12:2880862 NA 0.47 8.94 0.44 2.61e-17 Quantitative traits; LUSC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg18402987 chr7:1209562 NA 0.71 7.71 0.39 1.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg14563129 chr8:141290188 TRAPPC9 -0.71 -5.99 -0.31 5.4e-9 Cognitive performance; LUSC cis rs12210905 0.688 rs12213471 chr6:27406063 C/G cg08851530 chr6:28072375 NA 0.93 5.77 0.3 1.77e-8 Hip circumference adjusted for BMI; LUSC cis rs12711979 0.509 rs1031478 chr2:3827425 G/A cg17052675 chr2:3827356 NA -0.84 -20.23 -0.74 5.51e-60 Itch intensity from mosquito bite adjusted by bite size; LUSC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg04369109 chr6:150039330 LATS1 -0.58 -8.63 -0.43 2.49e-16 Lung cancer; LUSC cis rs35146811 0.660 rs3779046 chr7:99779243 A/G cg22906224 chr7:99728672 NA 0.48 6.68 0.34 1.03e-10 Coronary artery disease; LUSC cis rs1348850 0.914 rs12612857 chr2:178467144 A/G cg22681709 chr2:178499509 PDE11A -0.5 -9.14 -0.45 6.18e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); LUSC cis rs8031584 0.678 rs35098644 chr15:31145440 A/G cg14829155 chr15:31115871 NA -0.71 -10.33 -0.49 6.68e-22 Huntington's disease progression; LUSC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg05896524 chr21:47604654 C21orf56 0.48 7.31 0.37 1.98e-12 Testicular germ cell tumor; LUSC cis rs568617 0.716 rs77779142 chr11:65599656 C/T cg04055107 chr11:65626734 MUS81;CFL1 0.62 6.93 0.35 2.17e-11 Crohn's disease; LUSC cis rs9486715 0.838 rs9386473 chr6:96873341 C/A cg06623918 chr6:96969491 KIAA0776 0.93 17.19 0.69 6.65e-48 Headache; LUSC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg25427524 chr10:38739819 LOC399744 -0.58 -10.33 -0.49 6.63e-22 Extrinsic epigenetic age acceleration; LUSC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg27432699 chr2:27873401 GPN1 -0.56 -8.37 -0.42 1.57e-15 Total body bone mineral density; LUSC cis rs72781680 0.848 rs72780199 chr2:24016269 A/C cg20701182 chr2:24300061 SF3B14 0.54 5.81 0.3 1.46e-8 Lymphocyte counts; LUSC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg13206674 chr6:150067644 NUP43 0.63 10.37 0.49 5.14e-22 Lung cancer; LUSC cis rs11864453 0.647 rs8043606 chr16:72135319 T/C cg01557791 chr16:72042693 DHODH -0.43 -6.38 -0.33 6.06e-10 Fibrinogen levels; LUSC trans rs9944715 0.954 rs9959905 chr18:43811050 A/G cg01718231 chr17:29326311 RNF135 -0.53 -7.41 -0.38 1.03e-12 Red cell distribution width;Mean corpuscular volume; LUSC cis rs7267979 1.000 rs4815411 chr20:25350223 A/G cg08601574 chr20:25228251 PYGB -0.43 -6.6 -0.34 1.62e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg22823121 chr1:150693482 HORMAD1 0.49 7.06 0.36 9.73e-12 Melanoma; LUSC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg05084668 chr3:125655381 ALG1L -0.49 -7.01 -0.36 1.33e-11 Blood pressure (smoking interaction); LUSC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg24675658 chr1:53192096 ZYG11B -0.67 -10.66 -0.5 4.97e-23 Monocyte count; LUSC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.5 -6.86 -0.35 3.25e-11 Tonsillectomy; LUSC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg20295408 chr7:1910781 MAD1L1 0.41 5.84 0.3 1.26e-8 Schizophrenia; LUSC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg06873352 chr17:61820015 STRADA 0.72 12.86 0.58 5.23e-31 Prudent dietary pattern; LUSC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg24503407 chr1:205819492 PM20D1 0.77 13.24 0.59 1.8e-32 Menarche (age at onset); LUSC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg07741184 chr6:167504864 NA 0.37 6.72 0.35 7.82e-11 Crohn's disease; LUSC cis rs2075371 0.501 rs1646653 chr7:134024686 A/G cg11752832 chr7:134001865 SLC35B4 0.4 5.79 0.3 1.61e-8 Mean platelet volume; LUSC cis rs73198271 0.632 rs570396 chr8:8593652 A/G cg01851573 chr8:8652454 MFHAS1 0.4 6.22 0.32 1.52e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6681460 0.966 rs11208932 chr1:67097853 T/C cg02459107 chr1:67143332 SGIP1 0.46 8.55 0.42 4.52e-16 Presence of antiphospholipid antibodies; LUSC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg00343986 chr7:65444356 GUSB 0.44 6.3 0.33 9.48e-10 Calcium levels; LUSC cis rs4589502 0.800 rs1498499 chr15:67202620 C/T cg09911534 chr15:67153556 NA 0.5 6.5 0.34 2.92e-10 Lung cancer (smoking interaction); LUSC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg19748678 chr4:122722346 EXOSC9 0.49 7.53 0.38 4.64e-13 Type 2 diabetes; LUSC trans rs488628 0.848 rs1614410 chr3:118138386 A/G cg06621744 chr14:37052470 NKX2-8 -0.25 -5.96 -0.31 6.42e-9 White matter integrity (bipolar disorder risk interaction); LUSC cis rs7072216 0.666 rs11189592 chr10:100155642 C/A cg26618903 chr10:100175079 PYROXD2 -0.32 -5.73 -0.3 2.3e-8 Metabolite levels; LUSC cis rs9902453 0.967 rs12602065 chr17:28482488 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 7.95 0.4 2.93e-14 Coffee consumption (cups per day); LUSC cis rs6500395 1.000 rs871902 chr16:48593779 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.51 0.34 2.76e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs6964587 0.839 rs6949881 chr7:91433827 C/T cg22709100 chr7:91322751 NA 0.44 6.44 0.33 4.28e-10 Breast cancer; LUSC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg16049864 chr8:95962084 TP53INP1 -0.65 -12.08 -0.55 3.94e-28 Type 2 diabetes; LUSC cis rs12421382 1.000 rs12421382 chr11:109378071 C/T cg27471124 chr11:109292789 C11orf87 0.48 8.4 0.42 1.33e-15 Schizophrenia; LUSC cis rs854765 0.583 rs7214002 chr17:17852104 G/C cg16928487 chr17:17741425 SREBF1 -0.44 -8.6 -0.43 3.16e-16 Total body bone mineral density; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg16953067 chr3:9005230 RAD18 -0.48 -7.77 -0.39 9.49e-14 Electrocardiographic conduction measures; LUSC cis rs698813 0.674 rs11678787 chr2:44496315 C/T cg00619915 chr2:44497795 NA -0.53 -7.17 -0.37 4.86e-12 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs4253772 0.938 rs14842 chr22:46639457 A/T cg18190219 chr22:46762943 CELSR1 -0.52 -6.02 -0.31 4.71e-9 LDL cholesterol;Cholesterol, total; LUSC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg04317338 chr11:64019027 PLCB3 0.63 7.25 0.37 2.91e-12 Mean platelet volume; LUSC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg21573476 chr21:45109991 RRP1B -0.37 -5.88 -0.31 1.02e-8 Mean corpuscular volume; LUSC cis rs208520 0.955 rs208538 chr6:66964492 C/G cg07460842 chr6:66804631 NA -0.95 -12.41 -0.56 2.52e-29 Exhaled nitric oxide output; LUSC cis rs988712 0.705 rs11030104 chr11:27684517 C/T cg10635145 chr11:27742435 BDNF 0.48 6.26 0.32 1.19e-9 Obesity; LUSC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg03676636 chr4:99064102 C4orf37 0.27 5.8 0.3 1.54e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg19230755 chr7:65878503 NA 0.41 6.13 0.32 2.49e-9 Aortic root size; LUSC cis rs7267979 0.966 rs2482948 chr20:25296499 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.82 -17.73 -0.7 4.71e-50 Liver enzyme levels (alkaline phosphatase); LUSC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg06636001 chr8:8085503 FLJ10661 -0.53 -7.95 -0.4 3e-14 Joint mobility (Beighton score); LUSC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 7.6 0.38 3.12e-13 Electroencephalogram traits; LUSC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 8.17 0.41 6.29e-15 Schizophrenia; LUSC cis rs12908161 1.000 rs60957376 chr15:85280792 T/G cg17173187 chr15:85201210 NMB 0.49 9.31 0.45 1.74e-18 Schizophrenia; LUSC cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg11645453 chr3:52864694 ITIH4 0.34 7.97 0.4 2.49e-14 Body mass index; LUSC cis rs6460942 0.732 rs73677575 chr7:12286532 A/G cg06484146 chr7:12443880 VWDE -0.58 -6.11 -0.32 2.71e-9 Coronary artery disease; LUSC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg11494091 chr17:61959527 GH2 0.64 13.56 0.6 1.12e-33 Prudent dietary pattern; LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg04518342 chr5:131593106 PDLIM4 -0.54 -10.19 -0.49 2.09e-21 Acylcarnitine levels; LUSC cis rs7100689 0.622 rs7090351 chr10:82142047 T/G cg01528321 chr10:82214614 TSPAN14 0.87 13.37 0.59 6.24e-33 Post bronchodilator FEV1; LUSC cis rs7100689 0.784 rs4934139 chr10:82177023 C/A cg00277334 chr10:82204260 NA -0.5 -6.71 -0.34 8.23e-11 Post bronchodilator FEV1; LUSC cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg13010199 chr12:38710504 ALG10B -0.58 -9.09 -0.45 8.82e-18 Drug-induced liver injury (flucloxacillin); LUSC cis rs9790314 0.690 rs7633857 chr3:160844942 C/G cg03342759 chr3:160939853 NMD3 -0.42 -6.83 -0.35 3.91e-11 Morning vs. evening chronotype; LUSC cis rs372883 0.935 rs379592 chr21:30706470 A/G cg24692254 chr21:30365293 RNF160 -0.41 -5.68 -0.3 3e-8 Pancreatic cancer; LUSC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg17366294 chr4:99064904 C4orf37 0.58 10.23 0.49 1.53e-21 Colonoscopy-negative controls vs population controls; LUSC trans rs4332037 0.664 rs73046334 chr7:1887037 T/C cg11693508 chr17:37793320 STARD3 0.53 6.43 0.33 4.36e-10 Bipolar disorder; LUSC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.93 0.35 2.14e-11 Intelligence (multi-trait analysis); LUSC cis rs2282802 0.660 rs7726176 chr5:139547971 T/A cg26211634 chr5:139558579 C5orf32 -0.41 -7.59 -0.38 3.12e-13 Intelligence (multi-trait analysis); LUSC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg02574844 chr11:5959923 NA 0.42 6.6 0.34 1.59e-10 DNA methylation (variation); LUSC cis rs7408868 1.000 rs6512018 chr19:15282138 T/C cg14696996 chr19:15285081 NOTCH3 0.96 9.25 0.45 2.67e-18 Pulse pressure; LUSC cis rs61931739 0.892 rs73309466 chr12:34093146 A/G cg06521331 chr12:34319734 NA 0.38 6.22 0.32 1.52e-9 Morning vs. evening chronotype; LUSC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.43 6.56 0.34 2.04e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.77 -0.35 5.96e-11 Intelligence (multi-trait analysis); LUSC cis rs7113850 0.541 rs76874215 chr11:24235158 G/A ch.11.24196551F chr11:24239977 NA 1.0 9.09 0.45 9.2e-18 Bone fracture in osteoporosis; LUSC cis rs6541297 1.000 rs6674744 chr1:230279011 C/T cg05784532 chr1:230284198 GALNT2 0.53 7.97 0.4 2.55e-14 Coronary artery disease; LUSC trans rs2898290 0.578 rs34163377 chr8:11450213 C/G cg08975724 chr8:8085496 FLJ10661 0.43 6.09 0.32 3.06e-9 Systolic blood pressure; LUSC trans rs6502050 0.835 rs9898697 chr17:80100498 A/G cg07393940 chr7:158741817 NA 0.37 6.75 0.35 6.53e-11 Life satisfaction; LUSC cis rs1559088 0.948 rs6510346 chr19:33598526 T/A cg17764715 chr19:33622953 WDR88 0.6 8.34 0.42 2.02e-15 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs4727027 0.870 rs13237714 chr7:148884083 A/G cg23583168 chr7:148888333 NA -0.91 -16.96 -0.68 5.59e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs2455601 1.000 rs2455601 chr11:8899400 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.44 -7.3 -0.37 2.18e-12 Schizophrenia; LUSC trans rs75804782 0.641 rs3769123 chr2:239349328 C/G cg01134436 chr17:81009848 B3GNTL1 0.66 6.4 0.33 5.11e-10 Morning vs. evening chronotype;Chronotype; LUSC cis rs738322 1.000 rs4382 chr22:38570842 T/C cg17652424 chr22:38574118 PLA2G6 -0.29 -6.41 -0.33 5e-10 Cutaneous nevi; LUSC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg17554472 chr22:41940697 POLR3H -0.48 -5.84 -0.3 1.22e-8 Vitiligo; LUSC cis rs7973719 0.868 rs6486910 chr12:7356479 G/A cg07052231 chr12:7363540 PEX5 0.54 9.42 0.46 7.85e-19 IgG glycosylation; LUSC cis rs11155671 0.530 rs9383940 chr6:150226059 T/G cg13206674 chr6:150067644 NUP43 0.46 7.05 0.36 1e-11 Testicular germ cell tumor; LUSC cis rs950776 0.593 rs588765 chr15:78865425 T/C cg06917634 chr15:78832804 PSMA4 -0.73 -12.61 -0.57 4.3e-30 Sudden cardiac arrest; LUSC cis rs11155671 0.530 rs6939761 chr6:150210994 T/C cg09699651 chr6:150184138 LRP11 0.45 7.17 0.37 4.98e-12 Testicular germ cell tumor; LUSC cis rs6674970 0.932 rs12569193 chr1:151115186 C/T cg11822372 chr1:151115635 SEMA6C 0.55 8.44 0.42 9.44e-16 Childhood ear infection; LUSC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 11.07 0.52 1.76e-24 Alzheimer's disease; LUSC cis rs765787 0.530 rs11634794 chr15:45534492 A/C cg25801113 chr15:45476975 SHF 0.34 7.01 0.36 1.32e-11 Uric acid levels; LUSC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg16405210 chr4:1374714 KIAA1530 -0.57 -8.8 -0.43 7.35e-17 Obesity-related traits; LUSC cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg13256891 chr4:100009986 ADH5 -0.43 -5.97 -0.31 5.95e-9 Alcohol dependence; LUSC trans rs9291683 0.527 rs11727087 chr4:10096020 A/G cg26043149 chr18:55253948 FECH 0.51 7.79 0.39 8.56e-14 Bone mineral density; LUSC trans rs2228479 0.702 rs17226841 chr16:89828484 C/T cg24644049 chr4:85504048 CDS1 0.88 7.56 0.38 3.94e-13 Skin colour saturation; LUSC trans rs7829975 0.593 rs2921061 chr8:8317615 A/T cg27411982 chr8:10470053 RP1L1 0.4 6.35 0.33 7.01e-10 Mood instability; LUSC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg13390004 chr1:15929781 NA 0.42 6.98 0.36 1.61e-11 Systolic blood pressure; LUSC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg08847533 chr14:75593920 NEK9 -0.8 -13.94 -0.61 4e-35 Height; LUSC cis rs897984 0.683 rs9932572 chr16:30841642 A/G cg02466173 chr16:30829666 NA -0.69 -16.1 -0.66 1.5e-43 Dementia with Lewy bodies; LUSC cis rs748404 0.578 rs512628 chr15:43618734 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.58 8.81 0.43 7.06e-17 Lung cancer; LUSC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.61 7.59 0.38 3.31e-13 Lung function (FEV1/FVC); LUSC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.78 -0.3 1.74e-8 Depression; LUSC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg21545522 chr1:205238299 TMCC2 0.5 9.34 0.45 1.45e-18 Mean corpuscular volume;Mean platelet volume; LUSC cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg06454157 chr6:167490870 NA -0.23 -5.8 -0.3 1.51e-8 Crohn's disease; LUSC cis rs5758511 0.689 rs62240864 chr22:42563889 C/T cg00645731 chr22:42541494 CYP2D7P1 0.54 8.21 0.41 4.97e-15 Birth weight; LUSC cis rs11587400 0.679 rs6537836 chr1:115108923 T/C cg12756093 chr1:115239321 AMPD1 0.4 5.93 0.31 7.76e-9 Autism; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00357593 chr19:14530417 DDX39 -0.49 -6.09 -0.32 3.08e-9 Bipolar disorder and schizophrenia; LUSC cis rs11945232 1.000 rs4314250 chr4:88340969 A/G cg23841344 chr4:88312519 HSD17B11 0.64 9.8 0.47 4.34e-20 Intelligence (multi-trait analysis); LUSC trans rs941408 0.515 rs2110118 chr19:2775144 T/C cg19676328 chr12:49525230 TUBA1B -0.51 -7.33 -0.37 1.71e-12 Total cholesterol levels; LUSC cis rs4631830 0.657 rs2611502 chr10:51500301 A/G cg10326726 chr10:51549505 MSMB -0.37 -6.36 -0.33 6.63e-10 Prostate-specific antigen levels; LUSC cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg27129171 chr3:47204927 SETD2 -0.68 -11.05 -0.52 2.16e-24 Colorectal cancer; LUSC cis rs4654899 0.865 rs6665549 chr1:21475884 G/C cg02927042 chr1:21476669 EIF4G3 -0.36 -5.8 -0.3 1.51e-8 Superior frontal gyrus grey matter volume; LUSC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg06544989 chr22:39130855 UNC84B 0.36 6.28 0.33 1.04e-9 Menopause (age at onset); LUSC cis rs9487051 0.735 rs380774 chr6:109519623 C/T cg01475377 chr6:109611718 NA -0.36 -6.11 -0.32 2.72e-9 Reticulocyte fraction of red cells; LUSC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg03676636 chr4:99064102 C4orf37 0.34 7.52 0.38 5.05e-13 Colonoscopy-negative controls vs population controls; LUSC cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.47 0.33 3.4e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs72960926 0.744 rs72950548 chr6:74907794 T/C cg03266952 chr6:74778945 NA -0.78 -6.3 -0.33 9.2e-10 Metabolite levels (MHPG); LUSC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.52 8.79 0.43 8.13e-17 Prudent dietary pattern; LUSC trans rs6906287 0.625 rs9320649 chr6:118693665 A/G cg11635524 chr19:46850777 PPP5C -0.43 -6.12 -0.32 2.56e-9 Electrocardiographic conduction measures; LUSC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg20295408 chr7:1910781 MAD1L1 -0.51 -7.09 -0.36 8.15e-12 Bipolar disorder and schizophrenia; LUSC cis rs6977660 0.714 rs4719586 chr7:19825548 T/C cg07541023 chr7:19748670 TWISTNB 0.6 6.3 0.33 9.45e-10 Thyroid stimulating hormone; LUSC cis rs13256369 0.853 rs13256216 chr8:8577883 C/T cg18904891 chr8:8559673 CLDN23 0.56 7.23 0.37 3.32e-12 Obesity-related traits; LUSC cis rs7236492 0.872 rs78226032 chr18:77230822 G/A cg15644404 chr18:77186268 NFATC1 -0.56 -5.94 -0.31 7.35e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 8.55 0.42 4.63e-16 Menarche (age at onset); LUSC cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg15073853 chr19:18549131 ISYNA1 -0.31 -5.76 -0.3 1.93e-8 Breast cancer; LUSC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg04414720 chr1:150670196 GOLPH3L 0.52 8.02 0.4 1.75e-14 Melanoma; LUSC cis rs9653442 0.712 rs6749757 chr2:100730111 A/C cg22139774 chr2:100720529 AFF3 0.46 8.26 0.41 3.47e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.75e-10 Crohn's disease; LUSC cis rs10782582 0.586 rs5745383 chr1:76288590 G/C cg10523679 chr1:76189770 ACADM -0.49 -7.06 -0.36 9.81e-12 Daytime sleep phenotypes; LUSC cis rs921968 0.565 rs6723334 chr2:219629303 C/T cg02176678 chr2:219576539 TTLL4 0.58 10.24 0.49 1.41e-21 Mean corpuscular hemoglobin concentration; LUSC cis rs10193935 0.792 rs72794590 chr2:42378392 G/A cg27598129 chr2:42591480 NA -0.57 -7.6 -0.38 3.06e-13 Colonoscopy-negative controls vs population controls; LUSC trans rs61931739 0.534 rs10844801 chr12:34230940 A/T cg26384229 chr12:38710491 ALG10B 0.71 11.72 0.54 8.1e-27 Morning vs. evening chronotype; LUSC cis rs59698941 0.882 rs4705977 chr5:132245114 C/A cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.17e-10 Apolipoprotein A-IV levels; LUSC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.07 16.31 0.67 2.14e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg07606381 chr6:8435919 SLC35B3 0.73 12.17 0.55 1.86e-28 Motion sickness; LUSC cis rs12760731 0.565 rs12028023 chr1:178087408 G/A cg00404053 chr1:178313656 RASAL2 0.67 6.7 0.34 8.81e-11 Obesity-related traits; LUSC cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg00484396 chr16:3507460 NAT15 0.48 7.87 0.4 4.89e-14 Body mass index (adult); LUSC cis rs477692 0.935 rs557158 chr10:131420534 C/T cg26102564 chr10:131424627 MGMT 0.39 6.09 0.32 3.08e-9 Response to temozolomide; LUSC cis rs12530845 0.887 rs61360007 chr7:135316879 G/A cg23117316 chr7:135346802 PL-5283 -0.58 -9.31 -0.45 1.82e-18 Red blood cell traits; LUSC cis rs9393777 0.623 rs9358946 chr6:26478927 G/A cg12292205 chr6:26970375 C6orf41 -0.63 -7.57 -0.38 3.72e-13 Intelligence (multi-trait analysis); LUSC cis rs2050392 0.590 rs303433 chr10:30714963 A/T cg25182066 chr10:30743637 MAP3K8 -0.46 -6.5 -0.34 2.92e-10 Inflammatory bowel disease; LUSC cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg23262073 chr20:60523788 NA -0.4 -5.93 -0.31 7.71e-9 Body mass index; LUSC cis rs7617773 0.963 rs6766754 chr3:48182589 T/C cg11946769 chr3:48343235 NME6 -0.62 -9.45 -0.46 6.24e-19 Coronary artery disease; LUSC cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg26924012 chr15:45694286 SPATA5L1 1.12 20.31 0.74 2.75e-60 Homoarginine levels; LUSC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg12292205 chr6:26970375 C6orf41 0.68 11.53 0.53 4.12e-26 Schizophrenia; LUSC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg04944784 chr2:26401820 FAM59B -0.75 -10.94 -0.51 5.29e-24 Gut microbiome composition (summer); LUSC cis rs11031096 0.782 rs7130580 chr11:4169301 G/A cg18678763 chr11:4115507 RRM1 -0.55 -7.99 -0.4 2.22e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg08888203 chr3:10149979 C3orf24 0.66 9.26 0.45 2.47e-18 Alzheimer's disease; LUSC cis rs72627509 0.857 rs56155140 chr4:57824451 G/A cg26694713 chr4:57773883 REST 0.48 5.71 0.3 2.49e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC cis rs9325144 0.555 rs1813392 chr12:38692203 C/T cg26384229 chr12:38710491 ALG10B -0.65 -10.56 -0.5 1.06e-22 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg08677398 chr8:58056175 NA 0.52 6.99 0.36 1.46e-11 Developmental language disorder (linguistic errors); LUSC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg00343986 chr7:65444356 GUSB -0.42 -6.45 -0.33 3.89e-10 Aortic root size; LUSC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg19622623 chr12:86230825 RASSF9 0.44 6.17 0.32 1.97e-9 Major depressive disorder; LUSC cis rs559928 0.847 rs11601738 chr11:64159307 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 6.68 0.34 1.02e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; LUSC cis rs929354 0.772 rs1182365 chr7:157017255 A/T cg05182265 chr7:156933206 UBE3C 0.59 9.48 0.46 4.74e-19 Body mass index; LUSC cis rs7584330 0.628 rs73098849 chr2:238389739 G/A cg14458575 chr2:238380390 NA 0.56 6.92 0.35 2.31e-11 Prostate cancer; LUSC cis rs10733682 0.659 rs3906146 chr9:129463613 C/T cg00232160 chr9:129468157 NA 0.38 6.63 0.34 1.36e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg04518342 chr5:131593106 PDLIM4 -0.44 -7.68 -0.39 1.83e-13 Breast cancer; LUSC cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg03146154 chr1:46216737 IPP 0.54 8.3 0.41 2.66e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs10464366 0.560 rs11763728 chr7:39145862 C/T cg15212455 chr7:39170539 POU6F2 0.54 8.97 0.44 2.18e-17 IgG glycosylation; LUSC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg17366294 chr4:99064904 C4orf37 0.57 10.18 0.49 2.27e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7647973 0.696 rs3087866 chr3:49054692 A/G cg07636037 chr3:49044803 WDR6 0.92 12.02 0.55 6.95e-28 Menarche (age at onset); LUSC cis rs10911251 0.528 rs6669199 chr1:183082421 C/A ch.1.3577855R chr1:183094577 LAMC1 0.71 10.85 0.51 1.05e-23 Colorectal cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15401922 chr6:157802439 ZDHHC14 0.41 6.42 0.33 4.65e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs3960554 0.932 rs11975745 chr7:75843524 T/C cg19862616 chr7:65841803 NCRNA00174 0.89 9.56 0.46 2.71e-19 Eotaxin levels; LUSC cis rs1358748 0.522 rs11209001 chr1:67587723 C/T cg02640540 chr1:67518911 SLC35D1 0.67 6.55 0.34 2.15e-10 Tuberculosis; LUSC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg17968037 chr7:100024898 ZCWPW1 -0.4 -6.02 -0.31 4.51e-9 Platelet count; LUSC cis rs11048434 0.736 rs2041624 chr12:9111855 C/G cg04155231 chr12:9217510 LOC144571 0.3 5.66 0.3 3.26e-8 Sjögren's syndrome; LUSC cis rs193541 0.507 rs1466370 chr5:122083780 A/G cg19077854 chr5:122220652 SNX24 0.26 5.64 0.3 3.56e-8 Glucose homeostasis traits; LUSC cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -9.27 -0.45 2.33e-18 Bone mineral density; LUSC cis rs240764 0.853 rs2001102 chr6:100978351 C/T cg09795085 chr6:101329169 ASCC3 -0.41 -5.91 -0.31 8.42e-9 Neuroticism; LUSC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg14440974 chr22:39074834 NA -0.37 -6.14 -0.32 2.34e-9 Menopause (age at onset); LUSC cis rs7824557 0.603 rs7016671 chr8:11182455 A/G cg21293242 chr8:11204541 TDH 0.33 6.3 0.33 9.54e-10 Retinal vascular caliber; LUSC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg24675658 chr1:53192096 ZYG11B 0.75 12.91 0.58 3.37e-31 Monocyte count; LUSC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg21770322 chr7:97807741 LMTK2 0.41 7.02 0.36 1.27e-11 Prostate cancer (SNP x SNP interaction); LUSC cis rs17401966 0.964 rs17400510 chr1:10290421 T/C cg19773385 chr1:10388646 KIF1B -0.54 -8.42 -0.42 1.11e-15 Hepatocellular carcinoma; LUSC cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg04586622 chr2:25135609 ADCY3 0.42 8.98 0.44 1.97e-17 Body mass index; LUSC cis rs62458065 0.640 rs28587905 chr7:32533054 C/T cg20159608 chr7:32802032 NA -0.75 -9.41 -0.46 8.26e-19 Metabolite levels (HVA/MHPG ratio); LUSC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg06671706 chr8:8559999 CLDN23 0.49 6.43 0.33 4.36e-10 Obesity-related traits; LUSC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28595532 0.800 rs114321375 chr4:119341663 G/A cg21605333 chr4:119757512 SEC24D 1.02 8.31 0.41 2.41e-15 Cannabis dependence symptom count; LUSC cis rs11711311 0.955 rs12636240 chr3:113391282 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.0 0.31 5.06e-9 IgG glycosylation; LUSC cis rs6500395 0.926 rs1039343 chr16:48577507 T/G cg04672837 chr16:48644449 N4BP1 0.44 6.58 0.34 1.77e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7590368 0.715 rs56321198 chr2:10959292 C/A cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs1371867 0.846 rs1692007 chr8:101268343 T/C cg00191853 chr8:101177733 SPAG1 0.34 5.78 0.3 1.74e-8 Atrioventricular conduction; LUSC cis rs17818399 1.000 rs62136864 chr2:46829124 G/A cg02822958 chr2:46747628 ATP6V1E2 0.42 6.42 0.33 4.58e-10 Height; LUSC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg09365446 chr1:150670422 GOLPH3L 0.49 7.18 0.37 4.54e-12 Melanoma; LUSC cis rs5756813 0.754 rs4821708 chr22:38164106 C/T cg06521852 chr22:38141419 TRIOBP 0.44 6.58 0.34 1.79e-10 Optic cup area;Vertical cup-disc ratio; LUSC cis rs240764 0.621 rs12175456 chr6:101219511 A/T cg09795085 chr6:101329169 ASCC3 -0.44 -6.26 -0.32 1.19e-9 Neuroticism; LUSC cis rs67539049 1.000 rs56388647 chr8:11295084 T/C cg02771117 chr8:11279352 FAM167A;C8orf12 -0.4 -6.2 -0.32 1.69e-9 Itch intensity from mosquito bite; LUSC cis rs8018808 0.875 rs11159258 chr14:77880593 T/C cg20045696 chr14:77926864 AHSA1 0.35 5.75 0.3 2.01e-8 Myeloid white cell count; LUSC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg21285383 chr16:89894308 SPIRE2 0.31 6.64 0.34 1.24e-10 Vitiligo; LUSC cis rs2274273 0.563 rs79163357 chr14:55738449 G/A cg04306507 chr14:55594613 LGALS3 0.49 9.77 0.47 5.27e-20 Protein biomarker; LUSC cis rs7615952 0.932 rs6438948 chr3:125650045 A/T cg05084668 chr3:125655381 ALG1L 0.7 10.51 0.5 1.69e-22 Blood pressure (smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19307233 chr1:231377017 C1orf131;GNPAT -0.41 -6.2 -0.32 1.69e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10078 0.515 rs890984 chr5:479540 A/G cg08916839 chr5:415575 AHRR 0.75 7.1 0.36 7.63e-12 Fat distribution (HIV); LUSC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.68 10.23 0.49 1.55e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs10760123 1 rs10760123 chr9:123650534 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 6.77 0.35 5.7e-11 Allergic disease (asthma, hay fever or eczema); LUSC trans rs28647808 0.881 rs41316984 chr9:136259231 T/C cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC cis rs1801251 0.928 rs737028 chr2:233640750 T/C cg25237894 chr2:233734115 C2orf82 0.34 6.32 0.33 8.31e-10 Coronary artery disease; LUSC cis rs735396 0.770 rs2257764 chr12:121446446 T/A cg02403541 chr12:121454288 C12orf43 -0.7 -10.16 -0.49 2.71e-21 N-glycan levels; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg21638108 chr19:19431283 KIAA0892;SF4 -0.46 -6.15 -0.32 2.2e-9 Bipolar disorder and schizophrenia; LUSC cis rs3741798 1.000 rs2160588 chr12:12487447 C/T cg08615371 chr12:12503544 MANSC1 1.07 11.68 0.54 1.13e-26 Cerebrospinal fluid biomarker levels; LUSC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg11859384 chr17:80120422 CCDC57 0.36 5.65 0.3 3.43e-8 Life satisfaction; LUSC cis rs4356932 0.871 rs4859606 chr4:76965879 C/T cg00809888 chr4:76862425 NAAA 0.34 5.68 0.3 2.94e-8 Blood protein levels; LUSC cis rs12579753 1.000 rs11115015 chr12:82174543 T/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.97 -0.31 6.07e-9 Resting heart rate; LUSC cis rs965469 1.000 rs2236107 chr20:3285821 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -5.99 -0.31 5.36e-9 IFN-related cytopenia; LUSC cis rs6537837 1.000 rs3768486 chr1:110123971 A/G cg05049280 chr1:110155535 GNAT2 0.51 6.91 0.35 2.43e-11 Major depressive disorder; LUSC cis rs9902453 0.967 rs12449783 chr17:28527653 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.51 0.42 6.02e-16 Coffee consumption (cups per day); LUSC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.51 7.71 0.39 1.41e-13 Menarche (age at onset); LUSC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg18825119 chr6:163149453 PACRG;PARK2 0.32 5.66 0.3 3.28e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg23422044 chr7:1970798 MAD1L1 -0.61 -7.18 -0.37 4.64e-12 Bipolar disorder; LUSC cis rs433852 1.000 rs433852 chr19:49117104 C/T cg06677660 chr19:49140777 SEC1;DBP -0.58 -6.96 -0.36 1.85e-11 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1953600 1.000 rs1953600 chr10:81911725 A/G cg00277334 chr10:82204260 NA 0.49 7.7 0.39 1.59e-13 Sarcoidosis; LUSC cis rs2324229 0.828 rs1180230 chr6:83949261 T/C cg08257003 chr6:84140564 ME1 0.28 6.78 0.35 5.51e-11 Platelet-derived growth factor BB levels; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.98 0.4 2.42e-14 Alzheimer's disease; LUSC cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg18758796 chr5:131593413 PDLIM4 0.35 5.96 0.31 6.44e-9 Blood metabolite levels; LUSC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg11645453 chr3:52864694 ITIH4 -0.35 -8.14 -0.41 8.17e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg11645453 chr3:52864694 ITIH4 -0.39 -8.79 -0.43 8.09e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs9394438 0.628 rs2153947 chr6:37544930 A/G cg00985040 chr6:37553208 NA -0.38 -7.98 -0.4 2.39e-14 IgG glycosylation; LUSC cis rs3008870 1.000 rs2755240 chr1:67477339 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.94 15.26 0.64 3.04e-40 Lymphocyte percentage of white cells; LUSC cis rs13118159 0.651 rs4974599 chr4:1314430 A/C cg02018176 chr4:1364513 KIAA1530 0.55 9.76 0.47 5.74e-20 Longevity; LUSC cis rs9911578 0.835 rs58647683 chr17:56483194 T/C cg05425664 chr17:57184151 TRIM37 0.55 8.65 0.43 2.26e-16 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg14552801 chr7:65878734 NA -0.36 -5.74 -0.3 2.15e-8 Aortic root size; LUSC cis rs694739 0.726 rs516124 chr11:64128423 G/T cg23796481 chr11:64053134 BAD;GPR137 0.52 8.27 0.41 3.16e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; LUSC cis rs7267979 0.868 rs6138546 chr20:25216534 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.84 18.2 0.71 6.88e-52 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1395 0.677 rs113353646 chr2:27492674 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.52 7.69 0.39 1.68e-13 Blood metabolite levels; LUSC cis rs12704876 0.509 rs1464808 chr7:96363633 A/T cg03808172 chr7:96339361 SHFM1 0.5 7.73 0.39 1.24e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg26818010 chr10:134567672 INPP5A -0.82 -10.56 -0.5 1.14e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs939658 0.935 rs12903747 chr15:79449627 A/C cg17916960 chr15:79447300 NA 0.47 9.56 0.46 2.65e-19 Refractive error; LUSC cis rs2070997 0.667 rs10901291 chr9:133717881 C/T cg11464064 chr9:133710261 ABL1 0.48 5.65 0.3 3.47e-8 Response to amphetamines; LUSC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg20503657 chr10:835505 NA 1.19 16.28 0.67 2.87e-44 Eosinophil percentage of granulocytes; LUSC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg04518342 chr5:131593106 PDLIM4 0.36 6.85 0.35 3.62e-11 Blood metabolite levels; LUSC cis rs5769765 0.818 rs8140681 chr22:50292081 C/A cg15316289 chr22:50310904 ALG12;CRELD2 0.48 7.04 0.36 1.07e-11 Schizophrenia; LUSC cis rs1865760 1.000 rs3752421 chr6:25918688 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 6.78 0.35 5.42e-11 Height; LUSC cis rs11122272 0.735 rs2808597 chr1:231532351 T/C cg06096015 chr1:231504339 EGLN1 0.58 10.39 0.49 4.18e-22 Hemoglobin concentration; LUSC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg18099408 chr3:52552593 STAB1 -0.43 -7.53 -0.38 4.66e-13 Intelligence (multi-trait analysis); LUSC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg06740227 chr12:86229804 RASSF9 0.37 5.82 0.3 1.39e-8 Major depressive disorder; LUSC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.45 -8.65 -0.43 2.26e-16 Autism spectrum disorder or schizophrenia; LUSC cis rs12549902 0.800 rs4736999 chr8:41506152 C/G cg21772509 chr8:41503840 NKX6-3 0.65 10.6 0.5 7.91e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; LUSC cis rs754466 0.651 rs11002317 chr10:79617648 G/A cg17075019 chr10:79541650 NA -0.74 -11.82 -0.54 3.48e-27 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg07741184 chr6:167504864 NA 0.32 5.89 0.31 9.43e-9 Crohn's disease; LUSC cis rs6840360 0.571 rs7674244 chr4:152488302 T/C cg22705602 chr4:152727874 NA -0.34 -6.86 -0.35 3.31e-11 Intelligence (multi-trait analysis); LUSC cis rs11679564 0.714 rs4016031 chr2:37184754 C/T cg14987922 chr2:37194071 STRN 0.63 9.39 0.46 9.32e-19 Immature fraction of reticulocytes; LUSC cis rs6424115 0.931 rs2982390 chr1:24147830 G/C cg15997130 chr1:24165203 NA 0.53 8.71 0.43 1.39e-16 Immature fraction of reticulocytes; LUSC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg24813613 chr7:1882135 MAD1L1 0.42 7.17 0.37 4.96e-12 Bipolar disorder and schizophrenia; LUSC cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg16339924 chr4:17578868 LAP3 0.5 7.35 0.37 1.54e-12 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg25456477 chr12:86230367 RASSF9 0.33 5.8 0.3 1.55e-8 Major depressive disorder; LUSC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg20891283 chr12:69753455 YEATS4 0.73 11.62 0.54 1.99e-26 Cerebrospinal fluid biomarker levels; LUSC trans rs3942852 0.568 rs10769314 chr11:48097620 C/T cg15704280 chr7:45808275 SEPT13 -0.62 -8.13 -0.41 8.56e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs2227564 0.729 rs2688617 chr10:75646147 A/T cg23231163 chr10:75533350 FUT11 -0.43 -5.94 -0.31 7.3e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg23711669 chr6:146136114 FBXO30 0.74 13.27 0.59 1.41e-32 Lobe attachment (rater-scored or self-reported); LUSC trans rs11250098 0.583 rs66724331 chr8:10789345 C/A cg06636001 chr8:8085503 FLJ10661 -0.52 -7.24 -0.37 3.03e-12 Morning vs. evening chronotype; LUSC cis rs7107174 0.901 rs2450133 chr11:77925759 A/C cg02023728 chr11:77925099 USP35 0.52 7.15 0.36 5.64e-12 Testicular germ cell tumor; LUSC trans rs853679 0.546 rs200989 chr6:27816442 A/G cg01620082 chr3:125678407 NA -0.75 -7.36 -0.37 1.43e-12 Depression; LUSC cis rs929354 0.772 rs1182444 chr7:157024510 A/G cg17757837 chr7:157058334 UBE3C -0.82 -13.31 -0.59 1.01e-32 Body mass index; LUSC cis rs9341808 0.718 rs10943699 chr6:80940541 G/A cg08355045 chr6:80787529 NA 0.56 9.69 0.47 1e-19 Sitting height ratio; LUSC cis rs9815354 0.812 rs17282671 chr3:41887455 T/C cg03022575 chr3:42003672 ULK4 0.84 8.73 0.43 1.2e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs7577696 0.785 rs7592356 chr2:32370344 C/T cg02381751 chr2:32503542 YIPF4 -0.44 -6.12 -0.32 2.59e-9 Inflammatory biomarkers; LUSC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs735539 1.000 rs9579929 chr13:21282724 C/T cg04906043 chr13:21280425 IL17D 0.48 9.06 0.44 1.12e-17 Dental caries; LUSC cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg17420585 chr12:42539391 GXYLT1 -0.37 -7.38 -0.37 1.27e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg24562669 chr7:97807699 LMTK2 0.36 6.29 0.33 9.85e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs950169 0.922 rs4842946 chr15:84942331 G/A cg17507749 chr15:85114479 UBE2QP1 0.65 8.1 0.41 1.04e-14 Schizophrenia; LUSC cis rs12681288 0.523 rs112307130 chr8:962483 G/A cg04851639 chr8:1020857 NA -0.39 -7.94 -0.4 3.19e-14 Schizophrenia; LUSC cis rs9399135 1.000 rs6569988 chr6:135352303 C/A cg24558204 chr6:135376177 HBS1L 0.58 8.88 0.44 4.14e-17 Red blood cell count; LUSC cis rs1185460 0.967 rs4545564 chr11:118937518 T/C cg01677386 chr11:118938358 VPS11 -0.48 -6.86 -0.35 3.37e-11 Coronary artery disease; LUSC cis rs6693567 0.586 rs4970979 chr1:150483840 C/T cg15654264 chr1:150340011 RPRD2 0.45 7.32 0.37 1.89e-12 Migraine; LUSC cis rs4356932 0.967 rs28642977 chr4:76972731 C/T cg00809888 chr4:76862425 NAAA 0.34 5.78 0.3 1.75e-8 Blood protein levels; LUSC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg26380479 chr7:97908229 NA 0.26 5.94 0.31 7.33e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.4 -0.46 8.9e-19 Breast cancer; LUSC cis rs7106204 0.620 rs12805125 chr11:24258967 A/T ch.11.24196551F chr11:24239977 NA -0.72 -6.66 -0.34 1.14e-10 Response to Homoharringtonine (cytotoxicity); LUSC cis rs1950626 0.671 rs34675695 chr14:101447913 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.7 0.39 1.51e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs3733418 0.799 rs13110766 chr4:165956628 C/T cg08992305 chr4:165878219 TRIM61;C4orf39 -0.45 -5.91 -0.31 8.6e-9 Obesity-related traits; LUSC cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg05347473 chr6:146136440 FBXO30 -0.48 -8.07 -0.4 1.29e-14 Lobe attachment (rater-scored or self-reported); LUSC trans rs804280 0.509 rs4841639 chr8:11796093 A/T cg06636001 chr8:8085503 FLJ10661 0.55 8.13 0.41 8.74e-15 Myopia (pathological); LUSC cis rs6693567 0.507 rs9436120 chr1:150473084 T/C cg15654264 chr1:150340011 RPRD2 0.45 7.21 0.37 3.83e-12 Migraine; LUSC cis rs2625529 0.590 rs7183196 chr15:72544401 A/G cg16672083 chr15:72433130 SENP8 -0.49 -7.59 -0.38 3.13e-13 Red blood cell count; LUSC trans rs10802346 0.545 rs1770012 chr1:246426405 A/G cg22732515 chr19:44031385 ETHE1 0.64 10.42 0.5 3.27e-22 Fractional exhaled nitric oxide (childhood); LUSC trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg17470723 chr8:74884337 TCEB1 0.52 8.06 0.4 1.33e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg03676636 chr4:99064102 C4orf37 0.36 7.89 0.4 4.25e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg23985595 chr17:80112537 CCDC57 0.31 5.84 0.3 1.23e-8 Life satisfaction; LUSC cis rs10791097 0.694 rs10791103 chr11:130757161 G/A cg12179176 chr11:130786555 SNX19 0.86 14.9 0.63 7.55e-39 Autism spectrum disorder or schizophrenia;Schizophrenia; LUSC cis rs6665290 0.904 rs9727512 chr1:227185375 G/T cg10327440 chr1:227177885 CDC42BPA -1.21 -38.91 -0.91 3.99e-126 Myeloid white cell count; LUSC cis rs9788682 0.747 rs2958719 chr15:78743029 G/A cg24631222 chr15:78858424 CHRNA5 -0.64 -8.55 -0.42 4.48e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg11764359 chr7:65958608 NA -0.69 -10.57 -0.5 9.97e-23 Aortic root size; LUSC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg17158414 chr2:27665306 KRTCAP3 -0.32 -6.25 -0.32 1.27e-9 Total body bone mineral density; LUSC cis rs1113500 0.933 rs10881497 chr1:108634515 A/G cg11967332 chr1:108735228 SLC25A24 -0.42 -6.43 -0.33 4.34e-10 Growth-regulated protein alpha levels; LUSC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg01579765 chr21:45077557 HSF2BP -0.53 -11.17 -0.52 8.01e-25 Mean corpuscular volume; LUSC cis rs747782 0.639 rs61649224 chr11:48057640 G/A cg20307385 chr11:47447363 PSMC3 -0.64 -5.83 -0.3 1.33e-8 Intraocular pressure; LUSC cis rs9309473 0.687 rs11693531 chr2:73608614 C/G cg20560298 chr2:73613845 ALMS1 -0.57 -8.55 -0.42 4.34e-16 Metabolite levels; LUSC cis rs4555082 1.000 rs4277291 chr14:105759009 A/G cg27165867 chr14:105738592 BRF1 -0.53 -7.72 -0.39 1.36e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs9788682 0.747 rs2656073 chr15:78742276 G/T cg24631222 chr15:78858424 CHRNA5 0.64 8.59 0.43 3.36e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; LUSC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg04369109 chr6:150039330 LATS1 -0.55 -8.09 -0.4 1.1e-14 Lung cancer; LUSC cis rs8099014 0.861 rs4940705 chr18:56120155 G/A cg12907477 chr18:56117327 MIR122 0.45 7.01 0.36 1.33e-11 Platelet count; LUSC cis rs2734839 0.964 rs2234690 chr11:113291748 T/A cg14159747 chr11:113255604 NA 0.23 5.78 0.3 1.69e-8 Information processing speed; LUSC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.16 -0.32 2.09e-9 Developmental language disorder (linguistic errors); LUSC cis rs9815354 1.000 rs9876960 chr3:41985812 C/T cg03022575 chr3:42003672 ULK4 -0.51 -5.74 -0.3 2.11e-8 Pulse pressure;Diastolic blood pressure; LUSC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg03264133 chr6:25882463 NA 0.47 7.65 0.39 2.11e-13 Intelligence (multi-trait analysis); LUSC cis rs72781680 0.716 rs2712086 chr2:24004739 G/C cg08917208 chr2:24149416 ATAD2B 0.6 6.91 0.35 2.44e-11 Lymphocyte counts; LUSC cis rs1577917 0.655 rs2758849 chr6:86344296 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -5.81 -0.3 1.45e-8 Response to antipsychotic treatment; LUSC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg13607699 chr17:42295918 UBTF -0.54 -8.47 -0.42 7.71e-16 Total body bone mineral density; LUSC cis rs7119 0.717 rs12899390 chr15:77815238 A/C cg27398640 chr15:77910606 LINGO1 -0.3 -6.49 -0.33 3.14e-10 Type 2 diabetes; LUSC cis rs7666738 0.546 rs11097591 chr4:98910173 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.82 0.43 6.37e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs710216 0.843 rs710214 chr1:43439282 C/T cg22176566 chr1:43424700 SLC2A1 0.47 5.79 0.3 1.59e-8 Red cell distribution width; LUSC cis rs4619890 0.528 rs62289359 chr4:7897168 C/T cg24250820 chr4:7887609 AFAP1 0.36 6.13 0.32 2.44e-9 Glaucoma (primary open-angle); LUSC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg18681998 chr4:17616180 MED28 0.77 13.73 0.6 2.53e-34 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg14004847 chr7:1930337 MAD1L1 0.52 8.18 0.41 6.08e-15 Bipolar disorder and schizophrenia; LUSC cis rs11166629 1.000 rs4909330 chr8:135644369 T/C cg27224718 chr8:135614730 ZFAT 0.64 10.62 0.5 7.01e-23 Smoking quantity; LUSC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg26338869 chr17:61819248 STRADA 0.42 6.18 0.32 1.88e-9 Prudent dietary pattern; LUSC cis rs11690935 0.655 rs17614941 chr2:172541378 A/G cg13550731 chr2:172543902 DYNC1I2 0.48 7.33 0.37 1.74e-12 Schizophrenia; LUSC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.43 7.07 0.36 9.1e-12 Platelet count; LUSC cis rs79247733 0.786 rs2286442 chr22:30772686 C/T cg03868770 chr22:30783737 RNF215 -0.58 -6.9 -0.35 2.54e-11 Tonsillectomy; LUSC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg14092988 chr3:52407081 DNAH1 0.31 5.94 0.31 7.06e-9 Bipolar disorder; LUSC cis rs6693567 0.565 rs2264417 chr1:150368501 C/T cg15654264 chr1:150340011 RPRD2 0.45 7.19 0.37 4.39e-12 Migraine; LUSC trans rs3960554 0.660 rs55671363 chr7:75793405 T/C cg19862616 chr7:65841803 NCRNA00174 0.94 12.45 0.56 1.72e-29 Eotaxin levels; LUSC cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg00071950 chr4:10020882 SLC2A9 0.64 10.8 0.51 1.66e-23 Bone mineral density; LUSC cis rs2692947 0.770 rs2315417 chr2:96500289 T/C cg22654517 chr2:96458247 NA 0.39 7.7 0.39 1.52e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs11945232 1.000 rs11945232 chr4:88342369 A/G cg23841344 chr4:88312519 HSD17B11 -0.66 -10.54 -0.5 1.27e-22 Intelligence (multi-trait analysis); LUSC cis rs9393692 1.000 rs3999544 chr6:26285867 C/T cg13736514 chr6:26305472 NA -0.49 -9.71 -0.47 8.44e-20 Educational attainment; LUSC cis rs1728785 0.901 rs1728797 chr16:68570989 A/T cg02508848 chr16:68573721 ZFP90 -0.43 -5.77 -0.3 1.84e-8 Ulcerative colitis; LUSC trans rs877282 1.000 rs12779159 chr10:772143 T/C cg13042288 chr15:90349979 ANPEP -0.49 -6.9 -0.35 2.7e-11 Uric acid levels; LUSC cis rs637571 0.528 rs566266 chr11:65573587 A/C cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -6.03 -0.31 4.43e-9 Eosinophil percentage of white cells; LUSC cis rs1983891 1.000 rs4714485 chr6:41536587 T/G cg15051332 chr6:41514432 FOXP4 0.39 5.69 0.3 2.84e-8 Prostate cancer; LUSC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg12365402 chr11:9010492 NRIP3 -0.49 -9.32 -0.45 1.63e-18 Hemoglobin concentration; LUSC cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg23788917 chr6:8435910 SLC35B3 0.49 7.28 0.37 2.36e-12 Motion sickness; LUSC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg14159672 chr1:205819179 PM20D1 0.85 15.3 0.64 2.01e-40 Menarche (age at onset); LUSC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg07493874 chr5:1342172 CLPTM1L -0.28 -5.81 -0.3 1.47e-8 Lung cancer; LUSC cis rs151234 0.741 rs3194168 chr16:28603012 A/G cg01378222 chr16:28622494 SULT1A1 -0.64 -8.55 -0.42 4.58e-16 Platelet distribution width; LUSC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg06740227 chr12:86229804 RASSF9 0.45 7.19 0.37 4.37e-12 Major depressive disorder; LUSC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg16647868 chr5:131706066 SLC22A5 -0.4 -6.04 -0.31 4.03e-9 Breast cancer; LUSC cis rs9326248 0.954 rs8521 chr11:117067699 C/T cg16524733 chr11:117070046 TAGLN 0.42 7.31 0.37 2.02e-12 Blood protein levels; LUSC cis rs10504229 0.639 rs112926738 chr8:58054939 A/G cg11062466 chr8:58055876 NA 0.61 7.52 0.38 5.24e-13 Developmental language disorder (linguistic errors); LUSC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg02574844 chr11:5959923 NA -0.39 -5.98 -0.31 5.89e-9 DNA methylation (variation); LUSC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg08219700 chr8:58056026 NA 0.67 8.55 0.42 4.48e-16 Developmental language disorder (linguistic errors); LUSC trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg25482853 chr8:67687455 SGK3 1.18 16.97 0.68 5.1e-47 Lung disease severity in cystic fibrosis; LUSC cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.64 10.15 0.49 2.74e-21 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs3126085 0.935 rs12742573 chr1:152260103 A/C cg26876637 chr1:152193138 HRNR -0.44 -5.83 -0.3 1.3e-8 Atopic dermatitis; LUSC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.68 -10.88 -0.51 8.68e-24 Body mass index (adult); LUSC cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg15997130 chr1:24165203 NA 0.52 8.56 0.42 4.14e-16 Immature fraction of reticulocytes; LUSC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg07677032 chr17:61819896 STRADA 0.52 8.7 0.43 1.53e-16 Prudent dietary pattern; LUSC cis rs12618769 0.597 rs3729568 chr2:99100196 T/G cg10123293 chr2:99228465 UNC50 0.43 6.97 0.36 1.73e-11 Bipolar disorder; LUSC cis rs614226 0.516 rs1794748 chr12:120953758 A/G cg01236616 chr12:121019343 POP5 1.31 21.86 0.77 2.15e-66 Type 1 diabetes nephropathy; LUSC trans rs853679 0.556 rs34588114 chr6:28080628 C/A cg01620082 chr3:125678407 NA -0.85 -7.63 -0.39 2.53e-13 Depression; LUSC cis rs7659604 0.502 rs10013916 chr4:122702179 T/G cg20573242 chr4:122745356 CCNA2 -0.46 -6.85 -0.35 3.61e-11 Type 2 diabetes; LUSC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg21361702 chr7:150065534 REPIN1 0.46 6.69 0.34 9.53e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs2816062 0.813 rs6698315 chr1:18895806 A/G cg18795169 chr1:18902165 NA -1.02 -24.68 -0.8 2.72e-77 Urate levels in lean individuals; LUSC trans rs2262909 0.893 rs4244912 chr19:22203237 T/A cg05197062 chr11:11642011 GALNTL4 -0.51 -7.08 -0.36 8.34e-12 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg23583168 chr7:148888333 NA -0.84 -14.65 -0.63 7.06e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs72717009 0.825 rs10494360 chr1:161475750 G/A cg23840854 chr1:161414152 NA -0.92 -11.12 -0.52 1.22e-24 Rheumatoid arthritis; LUSC cis rs11252926 0.625 rs7903876 chr10:482678 T/C cg16386425 chr10:429943 DIP2C 0.37 5.75 0.3 2.06e-8 Psychosis in Alzheimer's disease; LUSC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg14004847 chr7:1930337 MAD1L1 -0.51 -7.79 -0.39 8.73e-14 Bipolar disorder and schizophrenia; LUSC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg22535103 chr8:58192502 C8orf71 -0.79 -9.93 -0.48 1.55e-20 Developmental language disorder (linguistic errors); LUSC cis rs16976116 0.851 rs28393427 chr15:55490981 A/G cg11288833 chr15:55489084 RSL24D1 0.5 5.98 0.31 5.65e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs3733585 0.673 rs10018204 chr4:9964570 C/T cg26043149 chr18:55253948 FECH -0.45 -6.97 -0.36 1.7e-11 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs11148252 0.740 rs9596643 chr13:52912380 G/A cg00495681 chr13:53174319 NA -0.51 -7.92 -0.4 3.59e-14 Lewy body disease; LUSC cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg00530320 chr1:46809349 NSUN4 0.57 8.78 0.43 8.67e-17 Menopause (age at onset); LUSC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg18876405 chr7:65276391 NA -0.54 -8.47 -0.42 7.77e-16 Aortic root size; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg01191584 chr2:27594002 SNX17;EIF2B4 0.44 6.31 0.33 8.62e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs911555 0.504 rs8021368 chr14:104074810 G/A cg24130564 chr14:104152367 KLC1 -0.7 -11.11 -0.52 1.29e-24 Intelligence (multi-trait analysis); LUSC cis rs7091068 0.566 rs1326220 chr10:95486155 G/A cg20715218 chr10:95462985 C10orf4 0.67 7.26 0.37 2.66e-12 Urinary tract infection frequency; LUSC cis rs71335811 1 rs71335811 chr19:49130070 TC/T cg06530960 chr19:49140787 SEC1;DBP -0.57 -7.85 -0.39 5.7e-14 Myeloid white cell count; LUSC cis rs9928842 0.941 rs8057145 chr16:75256251 A/G cg09066997 chr16:75300724 BCAR1 0.51 6.33 0.33 7.71e-10 Alcoholic chronic pancreatitis; LUSC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21659725 chr3:3221576 CRBN 0.89 18.15 0.7 1.07e-51 Intelligence (multi-trait analysis); LUSC cis rs9790314 1.000 rs1382426 chr3:161045933 G/A cg03342759 chr3:160939853 NMD3 -0.49 -8.17 -0.41 6.35e-15 Morning vs. evening chronotype; LUSC cis rs208520 0.821 rs9363572 chr6:67012231 C/T cg07460842 chr6:66804631 NA 0.88 8.93 0.44 2.87e-17 Exhaled nitric oxide output; LUSC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg21970626 chr13:21893289 NA -0.52 -9.55 -0.46 2.91e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; LUSC cis rs7113850 0.541 rs76671714 chr11:24231278 C/G ch.11.24196551F chr11:24239977 NA 1.01 9.09 0.45 8.71e-18 Bone fracture in osteoporosis; LUSC cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg05985134 chr18:33552581 C18orf21 0.52 7.09 0.36 8.03e-12 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs227833 0.826 rs227854 chr6:44701035 C/T cg20913747 chr6:44695427 NA -0.37 -5.65 -0.3 3.44e-8 Monobrow; LUSC cis rs4237845 0.537 rs10747787 chr12:58260657 A/G cg00677455 chr12:58241039 CTDSP2 0.73 11.38 0.53 1.43e-25 Intelligence (multi-trait analysis); LUSC trans rs6952808 0.743 rs4721097 chr7:1877503 G/T cg11244813 chr1:145039882 PDE4DIP 0.36 5.96 0.31 6.51e-9 Bipolar disorder and schizophrenia; LUSC cis rs11098499 0.754 rs28643450 chr4:120245242 G/A cg24375607 chr4:120327624 NA 0.76 12.21 0.56 1.33e-28 Corneal astigmatism; LUSC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg18876405 chr7:65276391 NA 0.59 9.61 0.47 1.82e-19 Aortic root size; LUSC cis rs7917772 0.582 rs7075269 chr10:104365724 C/T cg22532475 chr10:104410764 TRIM8 -0.25 -6.0 -0.31 5.11e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg04056025 chr13:45694609 GTF2F2 0.78 6.21 0.32 1.62e-9 Cognitive performance; LUSC trans rs35110281 0.626 rs162389 chr21:44936227 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.94 0.44 2.64e-17 Mean corpuscular volume; LUSC cis rs9902453 0.740 rs2729446 chr17:28102499 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.67 -0.54 1.26e-26 Coffee consumption (cups per day); LUSC cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg08807101 chr21:30365312 RNF160 -0.7 -12.17 -0.55 1.85e-28 Dental caries; LUSC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 14.61 0.62 1.05e-37 Allergic disease (asthma, hay fever or eczema); LUSC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg13902645 chr11:5959945 NA -0.58 -8.23 -0.41 4.32e-15 DNA methylation (variation); LUSC cis rs8044995 0.501 rs7189887 chr16:68353915 C/T cg05110241 chr16:68378359 PRMT7 -0.83 -8.92 -0.44 3.09e-17 Schizophrenia; LUSC cis rs17253792 0.908 rs74354306 chr14:56065778 T/G cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs11098499 0.691 rs10028773 chr4:120265259 C/G cg09307838 chr4:120376055 NA -0.62 -9.26 -0.45 2.57e-18 Corneal astigmatism; LUSC trans rs1973993 0.689 rs17375929 chr1:96962246 A/T cg10631902 chr5:14652156 NA -0.41 -6.03 -0.31 4.46e-9 Weight; LUSC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg09835421 chr16:68378352 PRMT7 -0.55 -6.16 -0.32 2.09e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg06636001 chr8:8085503 FLJ10661 0.6 9.19 0.45 4.37e-18 Mood instability; LUSC cis rs3087591 0.639 rs2342052 chr17:29721011 T/C cg24425628 chr17:29625626 OMG;NF1 0.49 7.49 0.38 6.29e-13 Hip circumference; LUSC cis rs921968 0.541 rs41461846 chr2:219313354 A/G cg02176678 chr2:219576539 TTLL4 -0.66 -11.76 -0.54 6.01e-27 Mean corpuscular hemoglobin concentration; LUSC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg00509249 chr6:109615579 CCDC162 -0.34 -6.12 -0.32 2.66e-9 Reticulocyte fraction of red cells; LUSC cis rs2692947 0.655 rs60090597 chr2:96406266 G/A cg23100626 chr2:96804247 ASTL 0.29 6.92 0.35 2.33e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg06784218 chr1:46089804 CCDC17 0.53 11.14 0.52 1.05e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs3847687 1.000 rs78233646 chr12:131520170 G/T cg13586425 chr12:131519906 GPR133 -0.27 -6.32 -0.33 8.31e-10 Longevity; LUSC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg06238570 chr21:40685208 BRWD1 -0.58 -9.27 -0.45 2.36e-18 Menarche (age at onset); LUSC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15369054 chr17:80825471 TBCD 0.68 10.73 0.51 2.72e-23 Breast cancer; LUSC cis rs425277 1.000 rs74877653 chr1:2065949 C/T cg03732007 chr1:2071316 PRKCZ 0.49 7.79 0.39 8.55e-14 Height; LUSC cis rs7666738 0.606 rs4699606 chr4:99095074 A/C cg03676636 chr4:99064102 C4orf37 -0.28 -5.82 -0.3 1.37e-8 Colonoscopy-negative controls vs population controls; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -8.41 -0.42 1.21e-15 Lymphocyte counts; LUSC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg21573476 chr21:45109991 RRP1B -0.4 -6.36 -0.33 6.52e-10 Mean corpuscular volume; LUSC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg14343924 chr8:8086146 FLJ10661 -0.42 -5.91 -0.31 8.23e-9 Mood instability; LUSC cis rs3820928 0.839 rs12470666 chr2:227876525 G/A cg11843606 chr2:227700838 RHBDD1 -0.54 -7.51 -0.38 5.59e-13 Pulmonary function; LUSC cis rs1957429 0.522 rs76721513 chr14:65403891 C/G cg23373153 chr14:65346875 NA -0.98 -7.73 -0.39 1.3e-13 Pediatric areal bone mineral density (radius); LUSC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg12463550 chr7:65579703 CRCP 0.62 5.69 0.3 2.77e-8 Diabetic kidney disease; LUSC cis rs11608355 0.545 rs11613023 chr12:109898047 T/C cg05360138 chr12:110035743 NA 0.9 11.49 0.53 5.61e-26 Neuroticism; LUSC cis rs1595825 0.945 rs6756641 chr2:198849672 T/G cg00982548 chr2:198649783 BOLL -0.57 -7.34 -0.37 1.65e-12 Ulcerative colitis; LUSC cis rs7605827 0.930 rs2111448 chr2:15599073 T/G cg19274914 chr2:15703543 NA 0.47 9.08 0.45 9.55e-18 Educational attainment (years of education); LUSC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg13393036 chr8:95962371 TP53INP1 -0.35 -6.76 -0.35 6.01e-11 Type 2 diabetes; LUSC cis rs9300255 0.602 rs2851435 chr12:123712416 G/A cg13010344 chr12:123464640 ARL6IP4 -0.47 -5.92 -0.31 8.19e-9 Neutrophil percentage of white cells; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg09683566 chr17:21002807 NA -0.4 -5.95 -0.31 6.72e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs765787 0.530 rs2413786 chr15:45525394 C/A cg24006582 chr15:45444508 DUOX1 -0.6 -8.93 -0.44 2.94e-17 Uric acid levels; LUSC cis rs4954585 0.659 rs4072435 chr2:137013901 C/T cg05194412 chr2:137003533 NA 0.41 7.57 0.38 3.79e-13 Colorectal cancer; LUSC cis rs1559088 0.947 rs10403238 chr19:33552405 A/G cg17764715 chr19:33622953 WDR88 0.58 7.88 0.4 4.62e-14 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9549367 0.826 rs9549713 chr13:113905308 G/T cg18105134 chr13:113819100 PROZ -0.68 -9.6 -0.47 1.9e-19 Platelet distribution width; LUSC cis rs1185460 0.967 rs2509121 chr11:118928253 C/T cg01677386 chr11:118938358 VPS11 -0.5 -7.0 -0.36 1.4e-11 Coronary artery disease; LUSC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg06637938 chr14:75390232 RPS6KL1 0.55 8.62 0.43 2.67e-16 Height; LUSC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg07870213 chr5:140052090 DND1 -0.74 -10.99 -0.52 3.51e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs11785400 1.000 rs6995314 chr8:143749718 A/G cg24634471 chr8:143751801 JRK -0.59 -8.91 -0.44 3.48e-17 Schizophrenia; LUSC cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg26384229 chr12:38710491 ALG10B 0.9 15.55 0.65 2.12e-41 Bladder cancer; LUSC cis rs9807989 0.839 rs1420099 chr2:102980543 C/G cg09003973 chr2:102972529 NA 0.44 6.02 0.31 4.5e-9 Asthma; LUSC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg04025307 chr7:1156635 C7orf50 0.42 5.88 0.31 9.84e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.73 -9.13 -0.45 6.87e-18 Gut microbiome composition (summer); LUSC cis rs7597155 1.000 rs6727897 chr2:69987384 A/G cg02498382 chr2:70120550 SNRNP27 -0.24 -5.83 -0.3 1.34e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9443189 0.570 rs7755068 chr6:76405700 A/G cg01950844 chr6:76311363 SENP6 0.67 6.73 0.35 7.37e-11 Prostate cancer; LUSC cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg00852783 chr1:26633632 UBXN11 0.6 9.63 0.47 1.59e-19 Granulocyte percentage of myeloid white cells; LUSC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg18099408 chr3:52552593 STAB1 -0.41 -6.96 -0.36 1.84e-11 Bipolar disorder; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg18831827 chr4:95373876 PDLIM5 -0.41 -5.97 -0.31 6.21e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs7819412 0.595 rs2409712 chr8:10986837 A/C cg15556689 chr8:8085844 FLJ10661 -0.43 -6.25 -0.32 1.27e-9 Triglycerides; LUSC cis rs9311676 0.632 rs7643057 chr3:58374015 C/T cg26110898 chr3:58419937 PDHB 0.42 6.75 0.35 6.62e-11 Systemic lupus erythematosus; LUSC cis rs6690583 1.000 rs10443172 chr1:85485768 T/C cg22153463 chr1:85462885 MCOLN2 -0.68 -8.21 -0.41 4.76e-15 Serum sulfate level; LUSC cis rs12791968 0.527 rs4755300 chr11:45013421 C/T cg11846598 chr11:44996168 LOC221122 0.58 7.13 0.36 6.33e-12 Inhibitory control; LUSC cis rs9419702 0.614 rs9419567 chr10:133535149 C/G cg04492858 chr10:133558786 NA 0.43 7.19 0.37 4.2e-12 Survival in rectal cancer; LUSC cis rs35146811 0.700 rs2950520 chr7:99827148 T/C cg22906224 chr7:99728672 NA -0.5 -6.99 -0.36 1.49e-11 Coronary artery disease; LUSC cis rs4409675 0.576 rs2474470 chr1:28234999 C/T cg23691781 chr1:28212827 C1orf38 0.33 7.96 0.4 2.68e-14 Corneal astigmatism; LUSC cis rs870825 0.860 rs60022249 chr4:185600772 T/C cg04058563 chr4:185651563 MLF1IP 0.79 11.12 0.52 1.2e-24 Blood protein levels; LUSC cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg04455712 chr21:45112962 RRP1B 0.45 8.49 0.42 6.82e-16 Mean corpuscular volume; LUSC cis rs7605378 1.000 rs10194076 chr2:200677663 T/C cg17644776 chr2:200775616 C2orf69 0.37 5.78 0.3 1.75e-8 Osteoporosis; LUSC cis rs13006833 0.739 rs12693568 chr2:191202637 A/G cg21644426 chr2:191273491 MFSD6 0.45 6.3 0.33 9.61e-10 Urinary metabolites; LUSC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg06028605 chr16:24865363 SLC5A11 0.68 10.29 0.49 9.04e-22 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg11764359 chr7:65958608 NA -0.7 -10.79 -0.51 1.7e-23 Aortic root size; LUSC cis rs16949788 1.000 rs80298548 chr15:66690448 A/G cg08120210 chr15:66682733 MAP2K1 -0.6 -5.96 -0.31 6.36e-9 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs950169 0.922 rs11639244 chr15:84832650 G/A cg12863693 chr15:85201151 NMB 0.36 7.35 0.37 1.56e-12 Schizophrenia; LUSC cis rs894734 0.535 rs7301643 chr12:54325796 G/T cg17410650 chr12:54324560 NA -0.6 -11.03 -0.52 2.55e-24 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); LUSC cis rs858239 0.600 rs7776644 chr7:23119307 C/T cg23682824 chr7:23144976 KLHL7 0.4 5.86 0.31 1.13e-8 Cerebrospinal fluid biomarker levels; LUSC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.43 -7.9 -0.4 4.03e-14 Prostate cancer (SNP x SNP interaction); LUSC cis rs7937682 0.855 rs7934922 chr11:111500026 T/C cg19812747 chr11:111475976 SIK2 -0.51 -7.24 -0.37 3.02e-12 Primary sclerosing cholangitis; LUSC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg02574844 chr11:5959923 NA -0.45 -6.32 -0.33 8.49e-10 DNA methylation (variation); LUSC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg03060546 chr3:49711283 APEH 0.71 11.95 0.55 1.23e-27 Resting heart rate; LUSC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg09044154 chr16:88155775 NA -0.55 -7.27 -0.37 2.52e-12 Menopause (age at onset); LUSC cis rs977987 0.741 rs10514393 chr16:75344476 C/T cg04384234 chr16:75411784 CFDP1 -0.42 -6.79 -0.35 5.19e-11 Dupuytren's disease; LUSC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.84 -0.35 3.81e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs7584330 0.518 rs74003105 chr2:238446851 T/C cg14458575 chr2:238380390 NA 0.58 6.82 0.35 4.36e-11 Prostate cancer; LUSC cis rs7923609 0.967 rs10740134 chr10:65315433 T/C cg01631684 chr10:65280961 REEP3 -0.43 -6.71 -0.34 8.47e-11 Educational attainment;Liver enzyme levels (alkaline phosphatase); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06376129 chr1:205180539 DSTYK -0.42 -6.29 -0.33 1.01e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs10207060 0.500 rs6731870 chr2:240708096 C/A cg07506560 chr2:240697449 NA 0.44 6.86 0.35 3.26e-11 Obesity-related traits; LUSC cis rs2404602 0.647 rs62026889 chr15:76917885 C/T cg23625390 chr15:77176239 SCAPER -0.65 -9.97 -0.48 1.18e-20 Blood metabolite levels; LUSC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg00166722 chr3:10149974 C3orf24 0.55 7.51 0.38 5.38e-13 Alzheimer's disease; LUSC trans rs2243480 0.803 rs36004293 chr7:65416512 T/C cg10756647 chr7:56101905 PSPH 0.87 8.46 0.42 8.32e-16 Diabetic kidney disease; LUSC cis rs2354432 0.607 rs2353999 chr1:146830686 T/C cg25205988 chr1:146714368 CHD1L -0.95 -8.76 -0.43 9.97e-17 Mitochondrial DNA levels; LUSC cis rs5769707 0.521 rs5769720 chr22:50062133 G/C cg10356904 chr22:49881777 NA -0.29 -5.78 -0.3 1.75e-8 Monocyte count;Monocyte percentage of white cells; LUSC cis rs1775715 0.737 rs2778661 chr10:32159191 C/T cg18675610 chr10:32216311 ARHGAP12 0.3 6.61 0.34 1.51e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs6912958 0.558 rs9444530 chr6:88343318 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.43 8.33 0.41 2.19e-15 Monocyte percentage of white cells; LUSC cis rs300703 0.604 rs373375 chr2:203350 C/A cg21211680 chr2:198530 NA 0.66 7.8 0.39 8e-14 Blood protein levels; LUSC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg05340658 chr4:99064831 C4orf37 0.65 11.03 0.52 2.39e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs1832871 0.965 rs2105333 chr6:158755437 T/G cg07165851 chr6:158734300 TULP4 -0.35 -5.92 -0.31 8.13e-9 Height; LUSC trans rs2228479 0.867 rs73276534 chr16:89950557 A/G cg24644049 chr4:85504048 CDS1 0.69 7.03 0.36 1.15e-11 Skin colour saturation; LUSC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg06484146 chr7:12443880 VWDE -0.74 -7.41 -0.38 1.02e-12 Coronary artery disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg00699235 chr12:49962218 MCRS1 0.41 6.17 0.32 1.96e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs3096299 0.685 rs4785568 chr16:89553707 A/G cg02034447 chr16:89574710 SPG7 0.44 6.53 0.34 2.4e-10 Multiple myeloma (IgH translocation); LUSC cis rs525592 1 rs525592 chr11:68195104 C/T cg20283391 chr11:68216788 NA -0.5 -7.04 -0.36 1.09e-11 Bone mineral density; LUSC cis rs854765 0.693 rs8079321 chr17:17760789 C/T cg16928487 chr17:17741425 SREBF1 -0.45 -8.72 -0.43 1.34e-16 Total body bone mineral density; LUSC cis rs10791323 0.572 rs10750551 chr11:133737462 G/A cg15485101 chr11:133734466 NA 0.39 7.02 0.36 1.27e-11 Childhood ear infection; LUSC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.15 -0.32 2.21e-9 Developmental language disorder (linguistic errors); LUSC cis rs4631830 0.863 rs3123078 chr10:51524971 A/G cg20129853 chr10:51489980 NA 0.33 6.75 0.35 6.65e-11 Prostate-specific antigen levels; LUSC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg18099408 chr3:52552593 STAB1 -0.4 -6.96 -0.36 1.81e-11 Bipolar disorder; LUSC cis rs460214 0.576 rs2836604 chr21:40041295 A/C cg21578987 chr21:40029669 ERG 0.42 6.51 0.34 2.74e-10 Response to cognitive-behavioural therapy in anxiety disorder; LUSC cis rs6456156 0.586 rs9459853 chr6:167465774 C/A cg07741184 chr6:167504864 NA 0.4 7.08 0.36 8.76e-12 Primary biliary cholangitis; LUSC cis rs2777491 1.000 rs66538814 chr15:41685917 G/T cg18705301 chr15:41695430 NDUFAF1 -0.74 -14.38 -0.62 8.22e-37 Ulcerative colitis; LUSC cis rs3007168 0.794 rs10138053 chr14:51615152 T/C cg23942311 chr14:51606299 NA -0.35 -6.61 -0.34 1.49e-10 Cancer; LUSC cis rs9470366 0.545 rs2395655 chr6:36645696 C/T cg08179530 chr6:36648295 CDKN1A -0.7 -10.66 -0.5 4.81e-23 QRS duration; LUSC trans rs4650994 0.525 rs2493858 chr1:178541210 A/G cg05059571 chr16:84539110 KIAA1609 -0.47 -8.95 -0.44 2.49e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg11812906 chr14:75593930 NEK9 0.54 8.22 0.41 4.57e-15 Height; LUSC cis rs10761482 0.906 rs7911934 chr10:62092090 A/G cg18175470 chr10:62150864 ANK3 -0.47 -6.74 -0.35 6.97e-11 Schizophrenia; LUSC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg20406979 chr6:167373233 NA 0.25 5.75 0.3 2.01e-8 Crohn's disease; LUSC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg22903471 chr2:27725779 GCKR -0.4 -6.82 -0.35 4.31e-11 Total body bone mineral density; LUSC cis rs950169 0.580 rs36126054 chr15:85177723 T/G cg17507749 chr15:85114479 UBE2QP1 0.57 7.32 0.37 1.88e-12 Schizophrenia; LUSC cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg04117972 chr1:227635322 NA 0.57 6.58 0.34 1.78e-10 Major depressive disorder; LUSC trans rs61931739 0.534 rs1843733 chr12:34047626 T/C cg13010199 chr12:38710504 ALG10B 0.52 7.91 0.4 3.72e-14 Morning vs. evening chronotype; LUSC cis rs2239547 0.563 rs4687699 chr3:53101224 C/T cg25643088 chr3:52874325 TMEM110 0.4 6.24 0.32 1.32e-9 Schizophrenia; LUSC cis rs12681287 0.547 rs4961197 chr8:87512436 T/C cg27223183 chr8:87520930 FAM82B -0.55 -7.34 -0.37 1.65e-12 Caudate activity during reward; LUSC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg12311346 chr5:56204834 C5orf35 -0.57 -8.85 -0.44 5.02e-17 Coronary artery disease; LUSC cis rs870825 0.616 rs10013562 chr4:185610486 A/G cg04058563 chr4:185651563 MLF1IP 0.83 13.34 0.59 7.69e-33 Blood protein levels; LUSC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg02463440 chr8:22132932 PIWIL2 0.44 7.96 0.4 2.65e-14 Hypertriglyceridemia; LUSC cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.5 -7.0 -0.36 1.41e-11 Alzheimer's disease (late onset); LUSC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg06640241 chr16:89574553 SPG7 0.85 15.13 0.64 9.2e-40 Multiple myeloma (IgH translocation); LUSC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg20476274 chr7:133979776 SLC35B4 0.85 15.85 0.66 1.39e-42 Mean platelet volume; LUSC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -13.29 -0.59 1.26e-32 Alzheimer's disease; LUSC cis rs9311676 0.656 rs62258120 chr3:58391128 G/A cg13750441 chr3:58318267 PXK 0.35 6.84 0.35 3.85e-11 Systemic lupus erythematosus; LUSC cis rs1799949 0.965 rs8070179 chr17:41202688 G/A cg25072359 chr17:41440525 NA 0.62 8.91 0.44 3.42e-17 Menopause (age at onset); LUSC cis rs3847687 0.869 rs11061300 chr12:131523261 G/A cg25772418 chr12:131519998 GPR133 -0.27 -5.69 -0.3 2.82e-8 Longevity; LUSC cis rs950169 0.922 rs4842941 chr15:84831312 G/C cg17507749 chr15:85114479 UBE2QP1 -0.67 -8.67 -0.43 1.96e-16 Schizophrenia; LUSC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg13798780 chr7:105162888 PUS7 0.55 5.95 0.31 6.83e-9 Bipolar disorder (body mass index interaction); LUSC cis rs950169 0.922 rs11635505 chr15:85097034 A/C cg17507749 chr15:85114479 UBE2QP1 -0.69 -9.16 -0.45 5.21e-18 Schizophrenia; LUSC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg04553112 chr3:125709451 NA -0.5 -5.7 -0.3 2.7e-8 Blood pressure (smoking interaction); LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg02405530 chr4:926135 TMEM175;GAK -0.48 -6.21 -0.32 1.57e-9 Cognitive function;Information processing speed; LUSC cis rs4380275 1.000 rs4380275 chr2:773278 C/T cg21665850 chr2:731073 NA 0.42 6.75 0.35 6.49e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); LUSC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg10356904 chr22:49881777 NA -0.32 -7.08 -0.36 8.77e-12 Monocyte count;Monocyte percentage of white cells; LUSC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg18306943 chr3:40428807 ENTPD3 0.39 5.99 0.31 5.41e-9 Renal cell carcinoma; LUSC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg03676636 chr4:99064102 C4orf37 0.33 7.19 0.37 4.22e-12 Colonoscopy-negative controls vs population controls; LUSC trans rs57221529 0.713 rs12522724 chr5:590742 T/C cg11887960 chr12:57824829 NA 0.55 6.69 0.34 9.64e-11 Lung disease severity in cystic fibrosis; LUSC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg20887711 chr4:1340912 KIAA1530 0.51 7.86 0.4 5.26e-14 Obesity-related traits; LUSC cis rs7258465 1.000 rs4808136 chr19:18618867 A/G cg11102782 chr19:18549136 ISYNA1 0.32 6.2 0.32 1.67e-9 Breast cancer; LUSC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg11752832 chr7:134001865 SLC35B4 0.56 8.78 0.43 8.5e-17 Mean platelet volume; LUSC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg07636037 chr3:49044803 WDR6 0.44 6.28 0.32 1.07e-9 Resting heart rate; LUSC cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg04998671 chr14:104000505 TRMT61A -0.39 -5.83 -0.3 1.28e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; LUSC cis rs11098499 0.954 rs28429722 chr4:120300093 G/A cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC trans rs9467711 0.790 rs10484439 chr6:26309908 G/A cg01620082 chr3:125678407 NA -0.6 -6.09 -0.32 3.15e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg06636001 chr8:8085503 FLJ10661 0.48 6.83 0.35 3.91e-11 Neuroticism; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg25091458 chr3:190232250 IL1RAP 0.46 6.55 0.34 2.17e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs12464483 0.524 rs1348898 chr2:30888026 C/A cg12454169 chr2:30669597 LCLAT1 0.6 8.0 0.4 2.12e-14 Pre-treatment pain in head and neck squamous cell carcinoma; LUSC cis rs7258465 1.000 rs34746918 chr19:18539744 C/T cg06462663 chr19:18546047 ISYNA1 0.42 6.97 0.36 1.65e-11 Breast cancer; LUSC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg14552801 chr7:65878734 NA -0.38 -5.9 -0.31 9.08e-9 Aortic root size; LUSC cis rs8072100 0.701 rs4794053 chr17:45769551 G/A cg19784903 chr17:45786737 TBKBP1 -0.42 -6.04 -0.31 4.11e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs73416724 0.841 rs78415183 chr6:43394041 T/G cg26312998 chr6:43337775 ZNF318 0.55 6.39 0.33 5.45e-10 Autism spectrum disorder or schizophrenia; LUSC cis rs10761482 0.861 rs4948410 chr10:62116047 G/A cg18175470 chr10:62150864 ANK3 -0.51 -7.25 -0.37 2.99e-12 Schizophrenia; LUSC cis rs7818345 0.967 rs11204040 chr8:19288525 T/A cg11303988 chr8:19266685 CSGALNACT1 0.36 6.96 0.36 1.8e-11 Language performance in older adults (adjusted for episodic memory); LUSC trans rs7572263 0.528 rs13025862 chr2:209072106 C/T cg15570148 chr3:61235985 FHIT 0.49 6.11 0.32 2.85e-9 Glioma;Non-glioblastoma glioma; LUSC cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 13.0 0.58 1.55e-31 Chronic sinus infection; LUSC cis rs977987 0.806 rs4993969 chr16:75411521 A/T cg04384234 chr16:75411784 CFDP1 -0.42 -7.23 -0.37 3.31e-12 Dupuytren's disease; LUSC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.51 -7.81 -0.39 7.37e-14 Lymphocyte counts; LUSC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg17376030 chr22:41985996 PMM1 0.48 5.93 0.31 7.5e-9 Vitiligo; LUSC cis rs12541635 0.677 rs1817939 chr8:107029820 A/G cg10147462 chr8:107024639 NA 0.67 14.15 0.61 6.05e-36 Age of smoking initiation; LUSC cis rs4555082 0.874 rs28625632 chr14:105748849 G/T cg27165867 chr14:105738592 BRF1 -0.51 -7.25 -0.37 2.86e-12 Mean platelet volume;Platelet distribution width; LUSC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg17279839 chr7:150038598 RARRES2 0.49 7.44 0.38 8.59e-13 Blood protein levels;Circulating chemerin levels; LUSC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg27170947 chr2:26402098 FAM59B -0.62 -9.26 -0.45 2.58e-18 Gut microbiome composition (summer); LUSC cis rs7246657 0.943 rs7252099 chr19:37933780 G/A cg23950597 chr19:37808831 NA -0.64 -7.6 -0.38 3.03e-13 Coronary artery calcification; LUSC cis rs1371867 0.817 rs1660314 chr8:101332953 C/T cg06636551 chr8:101224915 SPAG1 -0.44 -8.03 -0.4 1.63e-14 Atrioventricular conduction; LUSC cis rs524023 0.957 rs552307 chr11:64357539 G/A cg19131476 chr11:64387923 NRXN2 0.37 9.88 0.48 2.27e-20 Urate levels in obese individuals; LUSC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg07741184 chr6:167504864 NA 0.36 6.59 0.34 1.73e-10 Crohn's disease; LUSC cis rs2296342 0.652 rs2296338 chr6:33630816 G/A cg14003231 chr6:33640908 ITPR3 0.36 7.01 0.36 1.35e-11 Schizophrenia; LUSC cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg24642439 chr20:33292090 TP53INP2 0.5 7.57 0.38 3.67e-13 Height; LUSC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg07507251 chr3:52567010 NT5DC2 0.33 6.42 0.33 4.6e-10 Bipolar disorder; LUSC cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.51 6.95 0.36 1.9e-11 Tonsillectomy; LUSC cis rs4654899 0.802 rs4654724 chr1:21177210 C/T cg01072550 chr1:21505969 NA -0.52 -7.65 -0.39 2.22e-13 Superior frontal gyrus grey matter volume; LUSC cis rs4906332 1.000 rs11625172 chr14:103944912 G/A cg04998671 chr14:104000505 TRMT61A -0.45 -7.15 -0.36 5.46e-12 Coronary artery disease; LUSC cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 13.69 0.6 3.62e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.91 -0.31 8.64e-9 Vitiligo; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg00682015 chr13:76111918 COMMD6 -0.35 -6.02 -0.31 4.6e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs2274273 0.686 rs17253695 chr14:55574610 A/T cg04306507 chr14:55594613 LGALS3 -0.46 -9.14 -0.45 6.05e-18 Protein biomarker; LUSC trans rs4332037 0.851 rs28728306 chr7:1961814 C/A cg11693508 chr17:37793320 STARD3 0.66 8.2 0.41 5.26e-15 Bipolar disorder; LUSC cis rs17270561 0.609 rs6941933 chr6:25745702 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 7.99 0.4 2.17e-14 Iron status biomarkers; LUSC cis rs9399401 0.667 rs11155242 chr6:142691549 A/C cg04461802 chr6:142623433 GPR126 0.48 5.96 0.31 6.25e-9 Chronic obstructive pulmonary disease; LUSC cis rs75920871 0.528 rs7941428 chr11:116903384 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.51 -6.42 -0.33 4.68e-10 Subjective well-being; LUSC cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg08999081 chr20:33150536 PIGU 0.55 11.25 0.52 4.09e-25 Coronary artery disease; LUSC cis rs16917546 1.000 rs10995250 chr10:64396921 G/A cg03961010 chr10:64397487 ZNF365 -0.41 -6.53 -0.34 2.45e-10 Basal cell carcinoma; LUSC cis rs6500395 1.000 rs6500397 chr16:48642235 T/C cg04672837 chr16:48644449 N4BP1 0.46 6.7 0.34 8.81e-11 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs7829975 0.514 rs2976926 chr8:8261624 T/C cg14343924 chr8:8086146 FLJ10661 0.39 5.7 0.3 2.68e-8 Mood instability; LUSC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg05025164 chr4:1340916 KIAA1530 -0.43 -6.82 -0.35 4.18e-11 Obesity-related traits; LUSC cis rs12594515 1.000 rs8039974 chr15:45986665 A/G cg06207120 chr15:45996521 NA 0.4 6.07 0.32 3.54e-9 Waist circumference;Weight; LUSC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18758796 chr5:131593413 PDLIM4 -0.53 -9.19 -0.45 4.18e-18 Acylcarnitine levels; LUSC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg13798780 chr7:105162888 PUS7 0.56 6.04 0.31 4.04e-9 Bipolar disorder (body mass index interaction); LUSC cis rs7660520 0.524 rs12643521 chr4:183728242 C/G cg09197432 chr4:183729176 NA 0.69 9.18 0.45 4.55e-18 Pediatric autoimmune diseases; LUSC cis rs1322512 0.713 rs1744385 chr6:152940466 A/G cg27316956 chr6:152958899 SYNE1 -0.34 -5.71 -0.3 2.51e-8 Tonometry; LUSC cis rs11608355 0.846 rs4766472 chr12:109853602 C/G cg05360138 chr12:110035743 NA 0.61 8.19 0.41 5.79e-15 Neuroticism; LUSC trans rs11700980 0.551 rs2832041 chr21:30116018 C/A cg14791747 chr16:20752902 THUMPD1 0.55 6.01 0.31 4.94e-9 QRS complex (12-leadsum); LUSC cis rs300703 1.000 rs300703 chr2:239416 C/T cg21211680 chr2:198530 NA 0.73 7.58 0.38 3.37e-13 Blood protein levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20065718 chr12:133430224 CHFR 0.48 6.59 0.34 1.75e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1190552 0.846 rs3783382 chr14:102965437 A/T cg18135206 chr14:102964638 TECPR2 0.48 5.89 0.31 9.54e-9 Blood protein levels; LUSC cis rs909002 0.849 rs10798881 chr1:32101775 G/C cg01639898 chr1:32083012 HCRTR1 0.26 6.02 0.31 4.59e-9 Intelligence (multi-trait analysis); LUSC cis rs7584330 0.518 rs7585969 chr2:238439073 G/A cg14458575 chr2:238380390 NA 0.55 6.43 0.33 4.33e-10 Prostate cancer; LUSC cis rs6754311 0.731 rs2164210 chr2:136580287 T/C cg07169764 chr2:136633963 MCM6 -0.58 -7.55 -0.38 4.27e-13 Mosquito bite size; LUSC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg25456477 chr12:86230367 RASSF9 0.44 7.86 0.4 5.41e-14 Major depressive disorder; LUSC cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg22166914 chr1:53195759 ZYG11B -0.49 -7.65 -0.39 2.23e-13 Monocyte count; LUSC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg27572855 chr1:25598939 RHD 0.46 8.38 0.42 1.52e-15 Erythrocyte sedimentation rate; LUSC cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg23649088 chr2:200775458 C2orf69 -0.54 -6.53 -0.34 2.39e-10 Schizophrenia; LUSC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg16228356 chr17:43848958 NA 0.26 5.89 0.31 9.38e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.39 0.46 9.85e-19 Prudent dietary pattern; LUSC cis rs2880765 0.835 rs4526974 chr15:86024284 C/T cg13263323 chr15:86062960 AKAP13 -0.35 -5.66 -0.3 3.34e-8 Coronary artery disease; LUSC trans rs28647808 0.786 rs28649804 chr9:136257709 C/T cg12569217 chr2:109379859 RANBP2 0.61 6.01 0.31 4.92e-9 Blood protein levels; LUSC trans rs1997103 1.000 rs1997103 chr7:55395390 C/G cg20935933 chr6:143382018 AIG1 0.51 7.34 0.37 1.65e-12 QRS interval (sulfonylurea treatment interaction); LUSC cis rs7584330 0.554 rs76408976 chr2:238384784 C/T cg14458575 chr2:238380390 NA 0.76 8.83 0.44 5.94e-17 Prostate cancer; LUSC cis rs911119 0.837 rs2208289 chr20:23579526 A/G cg16589663 chr20:23618590 CST3 -0.58 -7.23 -0.37 3.22e-12 Chronic kidney disease; LUSC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg23758822 chr17:41437982 NA 1.06 20.07 0.74 2.54e-59 Menopause (age at onset); LUSC cis rs3820928 0.874 rs1949807 chr2:227891861 A/G cg11843606 chr2:227700838 RHBDD1 -0.52 -7.62 -0.38 2.63e-13 Pulmonary function; LUSC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.47 0.46 5.29e-19 Prudent dietary pattern; LUSC trans rs17685 0.712 rs6464994 chr7:75784668 C/T cg19862616 chr7:65841803 NCRNA00174 1.12 18.97 0.72 5.86e-55 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg01411255 chr17:61851458 DDX42;CCDC47 0.68 11.21 0.52 5.47e-25 Prudent dietary pattern; LUSC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg00814883 chr7:100076585 TSC22D4 -0.66 -8.42 -0.42 1.16e-15 Platelet count; LUSC cis rs6500602 0.702 rs1051308 chr16:4560301 A/G cg08645402 chr16:4508243 NA -0.52 -8.77 -0.43 9.02e-17 Schizophrenia; LUSC cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg12310025 chr6:25882481 NA -0.5 -9.07 -0.44 1.03e-17 Blood metabolite levels; LUSC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.64 10.59 0.5 8.35e-23 Lymphocyte counts; LUSC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg17366294 chr4:99064904 C4orf37 0.58 10.27 0.49 1.12e-21 Colonoscopy-negative controls vs population controls; LUSC cis rs7119 0.651 rs12904200 chr15:77845902 C/G cg27398640 chr15:77910606 LINGO1 -0.32 -6.92 -0.35 2.32e-11 Type 2 diabetes; LUSC trans rs2587949 0.615 rs2120512 chr3:4211943 T/G cg15139668 chr4:4577005 NA -0.41 -6.03 -0.31 4.44e-9 Periodontitis (DPAL); LUSC cis rs9300255 0.512 rs2851436 chr12:123667354 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.13 -0.32 2.47e-9 Neutrophil percentage of white cells; LUSC cis rs9467773 0.620 rs6925087 chr6:26592853 T/A cg11502198 chr6:26597334 ABT1 0.71 11.81 0.54 3.94e-27 Intelligence (multi-trait analysis); LUSC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.5 6.28 0.32 1.05e-9 Renal function-related traits (BUN); LUSC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02475777 chr4:1388615 CRIPAK 0.58 9.01 0.44 1.62e-17 Longevity; LUSC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg22903657 chr4:1355424 KIAA1530 -0.35 -5.78 -0.3 1.73e-8 Longevity; LUSC cis rs12891047 0.865 rs8011120 chr14:68258238 A/G cg20999565 chr14:68265668 ZFYVE26 -0.39 -6.01 -0.31 4.78e-9 Amyotrophic lateral sclerosis (sporadic); LUSC cis rs734999 0.572 rs2985857 chr1:2532624 C/T cg18932078 chr1:2524107 MMEL1 -0.33 -7.21 -0.37 3.77e-12 Ulcerative colitis; LUSC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg19468946 chr17:37922297 IKZF3 -0.39 -6.19 -0.32 1.78e-9 Self-reported allergy; LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg27340350 chr19:49559583 CGB7 0.38 6.12 0.32 2.65e-9 Risky sexual behaviors in alcohol dependence; LUSC cis rs7223966 1.000 rs752621 chr17:61901880 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.48 0.33 3.38e-10 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs7954584 0.523 rs11043280 chr12:122426643 T/C cg21016266 chr12:122356598 WDR66 0.59 8.88 0.44 4.28e-17 Mean corpuscular volume; LUSC cis rs4654899 0.802 rs12127519 chr1:21247365 C/T cg01072550 chr1:21505969 NA -0.48 -6.91 -0.35 2.4e-11 Superior frontal gyrus grey matter volume; LUSC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg26818010 chr10:134567672 INPP5A 0.85 11.1 0.52 1.38e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs1595825 0.838 rs73058878 chr2:198895078 T/G cg10547527 chr2:198650123 BOLL -0.52 -6.25 -0.32 1.23e-9 Ulcerative colitis; LUSC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg07952391 chr2:88470173 THNSL2 -0.4 -5.7 -0.3 2.68e-8 Response to metformin (IC50); LUSC cis rs61897795 0.657 rs174590 chr11:61616977 G/C cg21709803 chr11:61594965 FADS2 -0.37 -5.65 -0.3 3.52e-8 Neutrophil count;Sum basophil neutrophil counts; LUSC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg12311346 chr5:56204834 C5orf35 -0.92 -13.6 -0.6 7.64e-34 Initial pursuit acceleration; LUSC cis rs561341 0.941 rs4625780 chr17:30249214 A/C cg00745463 chr17:30367425 LRRC37B -0.68 -7.84 -0.39 6.14e-14 Hip circumference adjusted for BMI; LUSC cis rs597583 0.806 rs12224853 chr11:117394822 A/G cg27161313 chr11:117392002 DSCAML1 0.4 6.77 0.35 5.93e-11 Putamen volume; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg11698548 chr7:43769233 C7orf44 -0.4 -5.96 -0.31 6.3e-9 Hepatitis; LUSC cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.17 0.55 1.95e-28 Colorectal cancer; LUSC cis rs7590368 0.715 rs56025654 chr2:10960952 G/A cg15705551 chr2:10952987 PDIA6 0.57 6.2 0.32 1.62e-9 Educational attainment (years of education); LUSC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg18904891 chr8:8559673 CLDN23 -0.51 -6.63 -0.34 1.34e-10 Obesity-related traits; LUSC cis rs4700695 0.668 rs166180 chr5:65499225 C/T cg21114390 chr5:65439923 SFRS12 -0.5 -6.96 -0.36 1.81e-11 Facial morphology (factor 19); LUSC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.03 -0.31 4.45e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg24110177 chr3:50126178 RBM5 0.51 8.21 0.41 4.74e-15 Intelligence (multi-trait analysis); LUSC trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg23505145 chr19:12996616 KLF1 0.65 11.05 0.52 2.17e-24 Prostate cancer (SNP x SNP interaction); LUSC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg20203395 chr5:56204925 C5orf35 -0.87 -11.96 -0.55 1.11e-27 Initial pursuit acceleration; LUSC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg10802521 chr3:52805072 NEK4 -0.55 -8.82 -0.43 6.3e-17 Bipolar disorder; LUSC trans rs3733585 0.699 rs10017674 chr4:9967053 T/C cg26043149 chr18:55253948 FECH -0.46 -7.09 -0.36 7.93e-12 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg15147215 chr3:52552868 STAB1 -0.31 -6.2 -0.32 1.65e-9 Bipolar disorder; LUSC cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg13010199 chr12:38710504 ALG10B 0.69 10.64 0.5 6.03e-23 Bladder cancer; LUSC cis rs2012796 1.000 rs8008024 chr14:81818492 A/G cg02996355 chr14:81879375 NA 0.5 7.17 0.37 4.89e-12 Night sleep phenotypes; LUSC cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.77 12.33 0.56 4.77e-29 Colonoscopy-negative controls vs population controls; LUSC cis rs6496044 0.568 rs11855789 chr15:86066403 G/A cg13263323 chr15:86062960 AKAP13 -0.38 -6.27 -0.32 1.12e-9 Interstitial lung disease; LUSC cis rs6542838 0.582 rs6542845 chr2:99537600 C/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.55 -7.47 -0.38 7.15e-13 Fear of minor pain; LUSC cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg06145435 chr7:1022769 CYP2W1 0.33 7.05 0.36 1.01e-11 Longevity;Endometriosis; LUSC trans rs2243480 1.000 rs1715235 chr7:65488394 T/C cg10756647 chr7:56101905 PSPH 0.86 8.37 0.42 1.59e-15 Diabetic kidney disease; LUSC cis rs138918 0.967 rs105585 chr22:43557492 G/A cg08909806 chr22:43548696 TSPO 0.39 6.99 0.36 1.48e-11 Monocyte count; LUSC cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.33 -5.89 -0.31 9.37e-9 IgG glycosylation; LUSC cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg08085267 chr17:45401833 C17orf57 0.52 8.51 0.42 5.97e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg00310523 chr12:86230176 RASSF9 0.46 8.5 0.42 6.35e-16 Major depressive disorder; LUSC cis rs10504229 0.680 rs11777459 chr8:58044241 A/T cg22535103 chr8:58192502 C8orf71 -0.55 -6.04 -0.31 4.05e-9 Developmental language disorder (linguistic errors); LUSC cis rs3126085 0.935 rs7550106 chr1:152197202 C/T cg26876637 chr1:152193138 HRNR -0.41 -6.16 -0.32 2.1e-9 Atopic dermatitis; LUSC cis rs1461503 0.809 rs7121955 chr11:122845478 A/T cg27398637 chr11:122830231 C11orf63 -0.41 -6.57 -0.34 1.98e-10 Menarche (age at onset); LUSC cis rs12410462 0.581 rs7543931 chr1:227550976 A/T cg23173402 chr1:227635558 NA 0.55 6.22 0.32 1.49e-9 Major depressive disorder; LUSC cis rs317689 0.690 rs595348 chr12:69638610 T/C cg11871910 chr12:69753446 YEATS4 0.45 5.83 0.3 1.29e-8 Response to diuretic therapy; LUSC cis rs10779751 1.000 rs1064261 chr1:11288758 C/T cg08854313 chr1:11322531 MTOR 0.87 14.82 0.63 1.52e-38 Body mass index; LUSC cis rs9653442 0.675 rs12995420 chr2:100652578 T/C cg22139774 chr2:100720529 AFF3 -0.46 -7.98 -0.4 2.34e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); LUSC cis rs8013055 0.706 rs8003957 chr14:105971702 A/G cg19700328 chr14:106028568 NA -0.42 -7.0 -0.36 1.45e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); LUSC cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg23788917 chr6:8435910 SLC35B3 0.5 7.41 0.38 1.02e-12 Motion sickness; LUSC cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg08807101 chr21:30365312 RNF160 -0.53 -7.9 -0.4 4.17e-14 Dental caries; LUSC cis rs72781680 0.898 rs12623079 chr2:24103749 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.8 0.3 1.56e-8 Lymphocyte counts; LUSC cis rs9581857 0.685 rs10467687 chr13:28036516 G/A cg22138327 chr13:27999177 GTF3A 0.75 7.8 0.39 7.94e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); LUSC cis rs4604732 0.527 rs60444724 chr1:247623164 T/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.42 6.18 0.32 1.88e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs907683 0.570 rs3755056 chr2:220281016 T/A cg15015639 chr2:220282977 DES 0.29 6.76 0.35 6.04e-11 Resting heart rate; LUSC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg25767906 chr1:53392781 SCP2 -0.53 -9.47 -0.46 5.38e-19 Monocyte count; LUSC cis rs12618769 0.625 rs3820945 chr2:99105156 G/A cg10123293 chr2:99228465 UNC50 0.46 7.63 0.39 2.49e-13 Bipolar disorder; LUSC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg06600287 chr1:53387719 ECHDC2 -0.29 -6.24 -0.32 1.33e-9 Monocyte count; LUSC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg18825119 chr6:163149453 PACRG;PARK2 -0.35 -6.26 -0.32 1.16e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4704187 0.687 rs10462512 chr5:74387317 C/G cg03227963 chr5:74354835 NA 0.32 6.8 0.35 4.75e-11 Response to amphetamines; LUSC cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg18681998 chr4:17616180 MED28 -0.8 -14.2 -0.61 4.08e-36 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg12935359 chr14:103987150 CKB -0.52 -8.14 -0.41 7.69e-15 Body mass index; LUSC cis rs4343996 0.869 rs10266047 chr7:3476501 C/G cg21248987 chr7:3385318 SDK1 0.36 5.98 0.31 5.69e-9 Motion sickness; LUSC cis rs1178968 0.818 rs4717086 chr7:72777049 A/G cg25889504 chr7:72793014 NA 0.6 7.8 0.39 7.86e-14 Triglyceride levels; LUSC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg05844789 chr1:228464394 OBSCN -0.3 -5.71 -0.3 2.54e-8 Diastolic blood pressure; LUSC cis rs7106204 0.590 rs7114724 chr11:24239976 A/G ch.11.24196551F chr11:24239977 NA 1.14 14.62 0.62 9.32e-38 Response to Homoharringtonine (cytotoxicity); LUSC trans rs6600671 0.934 rs11249431 chr1:121286203 A/G cg00646200 chr1:148855367 NA -0.51 -8.05 -0.4 1.46e-14 Hip geometry; LUSC cis rs9925964 0.967 rs749767 chr16:31124407 C/T cg03418659 chr16:31128414 MYST1 -0.42 -6.78 -0.35 5.45e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs12579753 0.879 rs7958657 chr12:82135067 G/A cg21231944 chr12:82153410 PPFIA2 -0.41 -6.22 -0.32 1.52e-9 Resting heart rate; LUSC trans rs11039798 0.623 rs6485879 chr11:48587984 G/T cg03929089 chr4:120376271 NA 0.6 6.55 0.34 2.18e-10 Axial length; LUSC cis rs7267979 1.000 rs4815406 chr20:25341316 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.87 -20.34 -0.74 2.17e-60 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7605827 0.930 rs1990755 chr2:15616013 C/G cg19274914 chr2:15703543 NA 0.47 9.13 0.45 6.85e-18 Educational attainment (years of education); LUSC cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg24812749 chr6:127587940 RNF146 0.73 10.48 0.5 2.02e-22 Breast cancer; LUSC cis rs9837602 1.000 rs923470 chr3:99757792 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.09 -0.32 3.14e-9 Breast cancer; LUSC cis rs859767 0.709 rs4954154 chr2:135370656 G/A cg12500956 chr2:135428796 TMEM163 -0.28 -6.21 -0.32 1.61e-9 Neuroticism; LUSC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg27572855 chr1:25598939 RHD 0.43 7.75 0.39 1.12e-13 Erythrocyte sedimentation rate; LUSC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.75 -13.62 -0.6 6.9e-34 Intelligence (multi-trait analysis); LUSC cis rs2456568 0.531 rs7105060 chr11:93661268 C/A cg26875233 chr11:93583750 C11orf90 -0.31 -6.06 -0.31 3.76e-9 Response to serotonin reuptake inhibitors in major depressive disorder; LUSC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg26314531 chr2:26401878 FAM59B -0.68 -9.2 -0.45 3.91e-18 Gut microbiome composition (summer); LUSC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -6.97 -0.36 1.71e-11 Major depressive disorder; LUSC cis rs2219968 0.962 rs4573260 chr8:78942894 T/C cg00738934 chr8:78996279 NA 0.38 6.77 0.35 5.66e-11 Prostate cancer (SNP x SNP interaction); LUSC trans rs12145833 0.538 rs10926977 chr1:243411367 T/G cg25284624 chr1:224180302 NA 0.68 6.29 0.33 1.01e-9 Obesity (early onset extreme); LUSC cis rs2404602 0.735 rs12906143 chr15:76709523 T/A cg23625390 chr15:77176239 SCAPER -0.62 -9.49 -0.46 4.49e-19 Blood metabolite levels; LUSC cis rs2880765 0.835 rs7164106 chr15:86032590 T/C cg13263323 chr15:86062960 AKAP13 -0.35 -5.72 -0.3 2.38e-8 Coronary artery disease; LUSC cis rs3008870 1.000 rs2815351 chr1:67477980 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.88 12.75 0.57 1.33e-30 Lymphocyte percentage of white cells; LUSC cis rs4730250 0.708 rs3801965 chr7:106825628 G/T cg02696742 chr7:106810147 HBP1 -0.65 -9.81 -0.47 3.86e-20 Osteoarthritis; LUSC cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg24578937 chr1:2090814 PRKCZ 0.46 10.15 0.49 2.73e-21 Height; LUSC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg06915202 chr7:98029285 BAIAP2L1 -0.3 -6.04 -0.31 4.05e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.64 13.49 0.59 2.18e-33 Monocyte percentage of white cells; LUSC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.46 -8.71 -0.43 1.4e-16 Monocyte percentage of white cells; LUSC cis rs7215564 0.908 rs34785514 chr17:78661166 A/G cg09596252 chr17:78655493 RPTOR 0.55 6.07 0.32 3.4e-9 Myopia (pathological); LUSC cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg24112000 chr20:60950667 NA -0.44 -8.63 -0.43 2.45e-16 Colorectal cancer; LUSC cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg08999081 chr20:33150536 PIGU -0.53 -10.58 -0.5 9.77e-23 Glomerular filtration rate (creatinine); LUSC cis rs1506636 0.720 rs633590 chr7:123442156 G/A cg03229431 chr7:123269106 ASB15 0.48 7.69 0.39 1.61e-13 Plateletcrit;Platelet count; LUSC cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg11057378 chr10:81107060 PPIF 0.39 6.46 0.33 3.69e-10 Height; LUSC cis rs9905704 0.633 rs2632523 chr17:56506634 G/A cg19466818 chr17:56409534 MIR142 -0.32 -6.08 -0.32 3.26e-9 Testicular germ cell tumor; LUSC cis rs4746818 0.793 rs2805914 chr10:70859291 A/G cg11621586 chr10:70884670 VPS26A 0.97 9.56 0.46 2.73e-19 Left atrial antero-posterior diameter; LUSC cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg00071950 chr4:10020882 SLC2A9 0.58 9.96 0.48 1.27e-20 Bone mineral density; LUSC cis rs2439831 0.867 rs2920781 chr15:43924682 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.76 7.4 0.38 1.11e-12 Lung cancer in ever smokers; LUSC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg21028142 chr17:79581711 NPLOC4 0.32 7.61 0.38 2.77e-13 Eye color traits; LUSC cis rs11122272 0.735 rs2808602 chr1:231537303 A/G cg06096015 chr1:231504339 EGLN1 0.56 10.02 0.48 8.05e-21 Hemoglobin concentration; LUSC trans rs4650994 0.524 rs2209170 chr1:178607388 C/A cg05059571 chr16:84539110 KIAA1609 0.47 8.88 0.44 4.24e-17 HDL cholesterol levels;HDL cholesterol; LUSC trans rs11098499 0.820 rs6829903 chr4:120506884 C/T cg25214090 chr10:38739885 LOC399744 0.54 7.96 0.4 2.73e-14 Corneal astigmatism; LUSC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg09509183 chr1:209979624 IRF6 0.42 5.64 0.3 3.57e-8 Cleft lip with or without cleft palate; LUSC cis rs8179 0.761 rs42032 chr7:92237426 G/A cg15732164 chr7:92237376 CDK6 -0.46 -6.87 -0.35 3.09e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Neutrophil count;White blood cell count;Myeloid white cell count;Granulocyte count;White blood cell count (basophil); LUSC cis rs11690935 0.632 rs6737308 chr2:172872042 G/A cg13550731 chr2:172543902 DYNC1I2 0.55 8.49 0.42 6.99e-16 Schizophrenia; LUSC cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg11244672 chr19:19639970 YJEFN3 0.6 7.33 0.37 1.72e-12 Bipolar disorder; LUSC cis rs9952991 0.941 rs2542151 chr18:12779947 G/T cg23598886 chr18:12777645 NA 0.67 6.37 0.33 6.38e-10 Inflammatory skin disease; LUSC cis rs2204008 0.557 rs11520191 chr12:38197057 T/A cg26384229 chr12:38710491 ALG10B 0.91 15.66 0.65 7.95e-42 Bladder cancer; LUSC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg19468946 chr17:37922297 IKZF3 -0.44 -6.87 -0.35 3.1e-11 Self-reported allergy; LUSC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg15704280 chr7:45808275 SEPT13 1.02 17.62 0.69 1.38e-49 Coronary artery disease; LUSC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.44 6.76 0.35 6.09e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg13770153 chr20:60521292 NA -0.62 -8.86 -0.44 4.82e-17 Body mass index; LUSC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg00750074 chr16:89608354 SPG7 -0.47 -8.01 -0.4 1.87e-14 Multiple myeloma (IgH translocation); LUSC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg12292205 chr6:26970375 C6orf41 -0.58 -7.15 -0.36 5.62e-12 Intelligence (multi-trait analysis); LUSC cis rs11168618 0.967 rs11168619 chr12:48933605 G/C cg24011408 chr12:48396354 COL2A1 0.41 6.57 0.34 1.96e-10 Adiponectin levels; LUSC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.89 -0.4 4.45e-14 Chronic sinus infection; LUSC cis rs7264396 0.512 rs2425072 chr20:34293686 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.65 -0.43 2.18e-16 Total cholesterol levels; LUSC cis rs4690686 0.500 rs11725547 chr4:177268444 T/C cg17059388 chr4:177262070 NA 0.46 8.59 0.43 3.28e-16 Essential tremor; LUSC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -5.83 -0.3 1.28e-8 Menopause (age at onset); LUSC cis rs67478160 0.634 rs2295140 chr14:104216293 C/T cg01849466 chr14:104193079 ZFYVE21 -0.62 -10.39 -0.49 4.16e-22 Schizophrenia; LUSC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg19748678 chr4:122722346 EXOSC9 0.74 10.58 0.5 9.68e-23 Type 2 diabetes; LUSC cis rs7577851 0.514 rs12466648 chr2:69560024 A/G cg10773587 chr2:69614142 GFPT1 0.56 6.06 0.31 3.78e-9 Parkinson's disease (age of onset); LUSC cis rs7100689 0.577 rs9285726 chr10:82035150 A/T cg00277334 chr10:82204260 NA -0.45 -6.28 -0.32 1.07e-9 Post bronchodilator FEV1; LUSC cis rs7605827 0.897 rs1468912 chr2:15662922 A/G cg19274914 chr2:15703543 NA 0.47 9.19 0.45 4.44e-18 Educational attainment (years of education); LUSC cis rs7666738 0.576 rs7660951 chr4:98651581 T/A cg17366294 chr4:99064904 C4orf37 0.51 8.12 0.41 9.3e-15 Colonoscopy-negative controls vs population controls; LUSC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg22166914 chr1:53195759 ZYG11B -0.48 -7.62 -0.38 2.6e-13 Monocyte count; LUSC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg00945038 chr17:61921165 SMARCD2 0.53 9.54 0.46 3.22e-19 Prudent dietary pattern; LUSC cis rs28830936 0.510 rs2412640 chr15:42124082 C/T cg17847044 chr15:42102381 MAPKBP1 0.37 8.83 0.44 6.01e-17 Diastolic blood pressure; LUSC cis rs6500395 0.926 rs9936446 chr16:48645807 G/C cg04672837 chr16:48644449 N4BP1 0.47 6.66 0.34 1.16e-10 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg08798685 chr6:27730294 NA -0.41 -5.77 -0.3 1.76e-8 Parkinson's disease; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg27622405 chr5:54830971 PPAP2A;RNF138P1 0.45 6.38 0.33 5.78e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4909189 1.000 rs62493649 chr7:158135556 C/G cg23298862 chr7:158159286 PTPRN2 0.32 5.66 0.3 3.27e-8 Response to amphetamines; LUSC cis rs4076764 0.881 rs10917758 chr1:163430652 G/A cg24596788 chr1:163392923 NA -0.41 -6.98 -0.36 1.6e-11 Motion sickness; LUSC cis rs977987 0.898 rs12918974 chr16:75493943 T/A cg03315344 chr16:75512273 CHST6 0.53 9.98 0.48 1.07e-20 Dupuytren's disease; LUSC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg13114125 chr14:105738426 BRF1 -0.92 -15.88 -0.66 1.09e-42 Mean platelet volume;Platelet distribution width; LUSC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg04267008 chr7:1944627 MAD1L1 -0.56 -8.4 -0.42 1.28e-15 Bipolar disorder and schizophrenia; LUSC cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg26395211 chr5:140044315 WDR55 0.45 6.91 0.35 2.5e-11 Depressive symptoms (multi-trait analysis); LUSC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg06028605 chr16:24865363 SLC5A11 0.61 9.46 0.46 5.74e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg23583168 chr7:148888333 NA -0.87 -16.13 -0.66 1.07e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs7119 0.679 rs12909808 chr15:77816944 A/G cg27398640 chr15:77910606 LINGO1 -0.31 -6.57 -0.34 1.96e-10 Type 2 diabetes; LUSC cis rs965513 1.000 rs1561962 chr9:100546219 C/T cg13688889 chr9:100608707 NA -0.55 -8.17 -0.41 6.46e-15 Thyroid cancer;Thyroid cancer (Papillary, radiation-related); LUSC trans rs9329221 0.905 rs13252982 chr8:10255105 C/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.26 -0.41 3.48e-15 Neuroticism; LUSC cis rs870825 0.616 rs41278579 chr4:185622402 A/G cg04058563 chr4:185651563 MLF1IP 0.87 12.66 0.57 2.75e-30 Blood protein levels; LUSC cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.99 -0.36 1.5e-11 Monocyte percentage of white cells; LUSC cis rs12545109 0.959 rs12546307 chr8:57314790 T/A cg09654669 chr8:57350985 NA -0.61 -8.16 -0.41 7.11e-15 Obesity-related traits; LUSC cis rs11122272 0.766 rs2808614 chr1:231550168 A/G cg06096015 chr1:231504339 EGLN1 -0.53 -9.18 -0.45 4.66e-18 Hemoglobin concentration; LUSC cis rs9309473 0.519 rs7598901 chr2:73675844 C/T cg20560298 chr2:73613845 ALMS1 0.47 7.37 0.37 1.36e-12 Metabolite levels; LUSC cis rs9612 1.000 rs9612 chr19:44235517 A/G cg08581076 chr19:44259116 C19orf61 0.51 6.17 0.32 1.99e-9 Exhaled nitric oxide output; LUSC cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg13852791 chr20:30311386 BCL2L1 0.83 10.72 0.51 3e-23 Mean corpuscular hemoglobin; LUSC cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg20503657 chr10:835505 NA 0.6 7.76 0.39 1.06e-13 Eosinophil percentage of granulocytes; LUSC cis rs921968 0.565 rs35189512 chr2:219628759 T/C cg02176678 chr2:219576539 TTLL4 -0.58 -10.33 -0.49 6.84e-22 Mean corpuscular hemoglobin concentration; LUSC cis rs1451375 0.583 rs7776816 chr7:50583534 G/A cg18232548 chr7:50535776 DDC 0.54 7.58 0.38 3.45e-13 Malaria; LUSC cis rs1372520 0.684 rs2619341 chr4:90741773 A/G cg15133208 chr4:90757351 SNCA -0.53 -8.13 -0.41 8.37e-15 Neuroticism; LUSC cis rs977987 0.815 rs11149818 chr16:75419373 G/A cg03315344 chr16:75512273 CHST6 0.53 10.24 0.49 1.39e-21 Dupuytren's disease; LUSC cis rs4908769 0.660 rs302714 chr1:8486131 A/C cg00546117 chr1:8445545 RERE -0.28 -5.71 -0.3 2.46e-8 Allergy; LUSC cis rs3849570 1.000 rs4411908 chr3:81802418 A/C cg07356753 chr3:81810745 GBE1 -0.59 -9.61 -0.47 1.77e-19 Waist circumference;Body mass index; LUSC cis rs3858526 0.834 rs6578712 chr11:5987071 C/T cg05234568 chr11:5960015 NA -0.62 -8.82 -0.43 6.48e-17 DNA methylation (variation); LUSC cis rs61931739 0.500 rs7977186 chr12:34431486 C/G cg06521331 chr12:34319734 NA -0.4 -6.16 -0.32 2.13e-9 Morning vs. evening chronotype; LUSC cis rs6494488 0.500 rs76625439 chr15:65018904 G/C cg08069370 chr15:64387884 SNX1 -0.65 -5.72 -0.3 2.33e-8 Coronary artery disease; LUSC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg18765753 chr7:1198926 ZFAND2A -0.58 -10.82 -0.51 1.42e-23 Longevity;Endometriosis; LUSC cis rs11155671 0.530 rs9371542 chr6:150213085 A/T cg13206674 chr6:150067644 NUP43 0.43 6.45 0.33 4.02e-10 Testicular germ cell tumor; LUSC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg23601095 chr6:26197514 HIST1H3D 0.7 7.53 0.38 4.89e-13 Gout;Renal underexcretion gout; LUSC cis rs7267979 1.000 rs6076336 chr20:25319212 C/T cg08601574 chr20:25228251 PYGB -0.43 -6.61 -0.34 1.55e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7568458 0.636 rs11126995 chr2:85792408 A/T cg02493740 chr2:85810744 VAMP5 -0.51 -8.8 -0.43 7.35e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs939658 0.805 rs939661 chr15:79431063 A/G cg17916960 chr15:79447300 NA -0.53 -10.49 -0.5 2e-22 Refractive error; LUSC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg12963246 chr6:28129442 ZNF389 0.38 5.97 0.31 6.22e-9 Cardiac Troponin-T levels; LUSC cis rs9399401 0.667 rs1329707 chr6:142724439 T/C cg03128060 chr6:142623767 GPR126 0.58 9.64 0.47 1.45e-19 Chronic obstructive pulmonary disease; LUSC cis rs372883 0.869 rs2027605 chr21:30726773 A/G cg24692254 chr21:30365293 RNF160 0.39 5.68 0.3 2.88e-8 Pancreatic cancer; LUSC cis rs2235649 0.833 rs9926962 chr16:1851826 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.42 -6.14 -0.32 2.32e-9 Blood metabolite levels; LUSC cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg07606381 chr6:8435919 SLC35B3 0.74 12.46 0.56 1.65e-29 Motion sickness; LUSC cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg24812749 chr6:127587940 RNF146 0.89 13.12 0.58 5.18e-32 Breast cancer; LUSC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg11494091 chr17:61959527 GH2 0.64 13.72 0.6 2.8e-34 Prudent dietary pattern; LUSC cis rs3806933 0.522 rs11241100 chr5:110460958 C/T cg04022379 chr5:110408740 TSLP 0.65 9.42 0.46 7.84e-19 Eosinophilic esophagitis; LUSC cis rs11809207 0.951 rs111772533 chr1:26523404 C/G cg00147160 chr1:26503991 CNKSR1 0.42 6.88 0.35 2.93e-11 Height; LUSC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg03929089 chr4:120376271 NA -0.93 -15.96 -0.66 5.16e-43 Height; LUSC cis rs6964587 1.000 rs7800582 chr7:91701346 G/A cg22709100 chr7:91322751 NA 0.39 5.75 0.3 1.98e-8 Breast cancer; LUSC cis rs55794721 0.509 rs909834 chr1:25757996 A/G cg23205692 chr1:25664452 TMEM50A 0.39 5.76 0.3 1.94e-8 Plateletcrit;Mean corpuscular volume; LUSC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg10523679 chr1:76189770 ACADM -0.93 -14.5 -0.62 2.71e-37 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg15468180 chr1:107600409 PRMT6 -0.36 -5.83 -0.3 1.29e-8 Facial morphology (factor 21, depth of nasal alae); LUSC cis rs9457247 1.000 rs10946199 chr6:167404492 G/A cg25258033 chr6:167368657 RNASET2 0.46 7.49 0.38 6.24e-13 Crohn's disease; LUSC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg03233332 chr7:66118400 NA -0.42 -6.09 -0.32 3.05e-9 Aortic root size; LUSC trans rs11250098 0.541 rs6997839 chr8:10766028 T/C cg15556689 chr8:8085844 FLJ10661 -0.55 -7.73 -0.39 1.27e-13 Morning vs. evening chronotype; LUSC cis rs12701220 0.817 rs1058729 chr7:1087283 C/T cg26769984 chr7:1090371 C7orf50 0.68 10.3 0.49 8.39e-22 Bronchopulmonary dysplasia; LUSC cis rs2742234 0.541 rs10899786 chr10:43744583 G/A cg02780029 chr10:43622663 RET 0.35 5.71 0.3 2.56e-8 Hirschsprung disease; LUSC cis rs9463078 0.683 rs227847 chr6:44695493 A/G cg25276700 chr6:44698697 NA 0.31 6.08 0.32 3.22e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; LUSC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg13683864 chr3:40499215 RPL14 -1.11 -21.6 -0.76 2.22e-65 Renal cell carcinoma; LUSC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg14159672 chr1:205819179 PM20D1 -0.77 -14.8 -0.63 1.83e-38 Monocyte percentage of white cells; LUSC cis rs868036 0.609 rs28742003 chr15:68127769 C/T cg05925327 chr15:68127851 NA -0.47 -6.83 -0.35 4.1e-11 Restless legs syndrome; LUSC cis rs1003719 0.762 rs6517402 chr21:38447423 A/C cg10648535 chr21:38446584 PIGP;TTC3 0.69 11.33 0.53 2.21e-25 Eye color traits; LUSC cis rs12136530 0.774 rs4912097 chr1:19784410 C/G cg01832549 chr1:19774989 CAPZB -0.31 -5.68 -0.3 2.89e-8 Lead levels in blood; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg25248346 chr19:41869851 B9D2;TMEM91 -0.43 -6.48 -0.33 3.22e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs1950626 0.750 rs72700530 chr14:101429459 G/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.44 7.75 0.39 1.08e-13 Pelvic organ prolapse (moderate/severe); LUSC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg02675527 chr2:114030824 PAX8;LOC440839 0.37 5.75 0.3 2.07e-8 Lymphocyte counts; LUSC cis rs34779708 0.931 rs4934723 chr10:35381763 A/G cg03585969 chr10:35415529 CREM 0.62 9.1 0.45 8.41e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03576123 chr11:487126 PTDSS2 -1.0 -10.71 -0.51 3.24e-23 Body mass index; LUSC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg00745463 chr17:30367425 LRRC37B -0.66 -8.09 -0.4 1.14e-14 Hip circumference adjusted for BMI; LUSC cis rs7827545 1.000 rs7832857 chr8:135565477 A/G cg17885191 chr8:135476712 NA 0.56 8.35 0.42 1.87e-15 Hypertension (SNP x SNP interaction); LUSC cis rs9479482 1.000 rs9479482 chr6:150358012 T/C cg25797454 chr6:150327115 RAET1K 0.34 7.8 0.39 8.18e-14 Alopecia areata; LUSC cis rs7804356 0.861 rs111373218 chr7:26859152 G/A cg03456212 chr7:26904342 SKAP2 -0.53 -6.17 -0.32 2.01e-9 Type 1 diabetes; LUSC cis rs394563 0.622 rs237024 chr6:149721965 T/C cg03678062 chr6:149772716 ZC3H12D -0.31 -6.44 -0.33 4.26e-10 Dupuytren's disease; LUSC cis rs4363385 0.550 rs2050673 chr1:152923698 C/T cg25856811 chr1:152973957 SPRR3 -0.36 -5.9 -0.31 9.03e-9 Inflammatory skin disease; LUSC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 21.13 0.76 1.58e-63 Prudent dietary pattern; LUSC cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg11584989 chr19:19387371 SF4 -0.6 -7.08 -0.36 8.81e-12 Bipolar disorder; LUSC cis rs7246967 0.673 rs3853650 chr19:22880490 A/G cg23217946 chr19:22817039 ZNF492 0.42 5.95 0.31 6.66e-9 Bronchopulmonary dysplasia; LUSC cis rs9611519 1.000 rs2057070 chr22:41564287 T/C cg13813247 chr22:41461852 NA -0.37 -6.77 -0.35 5.91e-11 Neuroticism; LUSC cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -8.86 -0.44 4.84e-17 Monocyte percentage of white cells; LUSC cis rs3096299 0.504 rs4785574 chr16:89568875 A/G cg06640241 chr16:89574553 SPG7 0.83 14.56 0.62 1.53e-37 Multiple myeloma (IgH translocation); LUSC cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg20283391 chr11:68216788 NA -0.5 -7.23 -0.37 3.42e-12 Total body bone mineral density; LUSC cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.58 8.8 0.43 7.56e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs9325144 0.647 rs35254764 chr12:39102928 T/C cg26384229 chr12:38710491 ALG10B -0.62 -9.7 -0.47 9.52e-20 Morning vs. evening chronotype; LUSC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg22535103 chr8:58192502 C8orf71 -0.64 -7.32 -0.37 1.9e-12 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg17366294 chr4:99064904 C4orf37 0.55 9.6 0.47 1.98e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs1568889 1.000 rs12804198 chr11:28143114 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.6 8.66 0.43 2.08e-16 Bipolar disorder; LUSC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.65 -0.34 1.21e-10 Lung cancer; LUSC cis rs11098499 0.739 rs6534130 chr4:120131339 A/T cg24375607 chr4:120327624 NA -0.69 -10.81 -0.51 1.47e-23 Corneal astigmatism; LUSC cis rs6489882 0.934 rs1859331 chr12:113376331 C/A cg20102336 chr12:113376681 OAS3 -0.41 -6.05 -0.31 3.9e-9 Chronic lymphocytic leukemia; LUSC cis rs9914988 0.943 rs28847895 chr17:27172520 T/C cg09479241 chr17:27052676 TLCD1 0.42 5.86 0.31 1.09e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs11209002 0.567 rs2224501 chr1:67532526 G/T cg02640540 chr1:67518911 SLC35D1 0.6 8.17 0.41 6.36e-15 Crohn's disease; LUSC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg13298116 chr11:62369859 EML3;MTA2 0.59 9.58 0.46 2.25e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2455601 0.786 rs3763914 chr11:8940703 G/T cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -7.13 -0.36 6.26e-12 Schizophrenia; LUSC cis rs72627509 1.000 rs57265257 chr4:57839280 A/T cg26694713 chr4:57773883 REST 0.5 5.87 0.31 1.05e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs796364 0.789 rs1653297 chr2:201075483 C/T cg17644776 chr2:200775616 C2orf69 0.43 6.54 0.34 2.27e-10 Schizophrenia; LUSC cis rs757110 0.866 rs5213 chr11:17408404 C/T cg15432903 chr11:17409602 KCNJ11 0.62 10.61 0.5 7.42e-23 Type 2 diabetes; LUSC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg24829409 chr8:58192753 C8orf71 -0.56 -6.08 -0.32 3.35e-9 Developmental language disorder (linguistic errors); LUSC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg20887711 chr4:1340912 KIAA1530 0.53 8.04 0.4 1.59e-14 Obesity-related traits; LUSC cis rs9341835 0.741 rs6929702 chr6:64144114 T/C cg03326410 chr6:64151739 NA -0.36 -6.02 -0.31 4.53e-9 Schizophrenia; LUSC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg18827107 chr12:86230957 RASSF9 -0.49 -7.12 -0.36 6.8e-12 Major depressive disorder; LUSC cis rs500891 1.000 rs13207536 chr6:84188476 A/G cg08257003 chr6:84140564 ME1 0.33 6.93 0.35 2.16e-11 Platelet-derived growth factor BB levels; LUSC cis rs239198 0.521 rs13198473 chr6:101337779 C/T cg09795085 chr6:101329169 ASCC3 0.41 5.87 0.31 1.07e-8 Menarche (age at onset); LUSC cis rs4664304 0.802 rs3749114 chr2:160832996 A/T cg23995753 chr2:160760732 LY75 -0.33 -6.13 -0.32 2.41e-9 Crohn's disease;Inflammatory bowel disease; LUSC cis rs2180341 0.521 rs12203812 chr6:127617816 A/T cg24812749 chr6:127587940 RNF146 0.5 7.19 0.37 4.2e-12 Breast cancer; LUSC cis rs9788721 0.967 rs55853698 chr15:78857939 T/G cg18825076 chr15:78729989 IREB2 -0.5 -7.52 -0.38 5.05e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg02153584 chr22:29168773 CCDC117 0.59 8.92 0.44 3.16e-17 Lymphocyte counts; LUSC cis rs7843479 0.601 rs4422769 chr8:21844265 A/G cg17168535 chr8:21777572 XPO7 0.87 16.11 0.66 1.29e-43 Mean corpuscular volume; LUSC cis rs2573652 1.000 rs12441080 chr15:100516968 A/G cg09918751 chr15:100517450 ADAMTS17 0.42 7.93 0.4 3.34e-14 Height; LUSC cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg23788917 chr6:8435910 SLC35B3 0.48 7.14 0.36 5.95e-12 Motion sickness; LUSC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg13114125 chr14:105738426 BRF1 -0.9 -15.44 -0.65 5.97e-41 Mean platelet volume;Platelet distribution width; LUSC cis rs9790314 1.000 rs6775627 chr3:160953609 A/G cg03342759 chr3:160939853 NMD3 -0.5 -8.43 -0.42 1.07e-15 Morning vs. evening chronotype; LUSC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg09509183 chr1:209979624 IRF6 0.43 5.73 0.3 2.25e-8 Cleft lip with or without cleft palate; LUSC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.56 10.16 0.49 2.69e-21 Electroencephalogram traits; LUSC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg00166722 chr3:10149974 C3orf24 -0.53 -7.64 -0.39 2.3e-13 Alzheimer's disease; LUSC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg04121214 chr22:50244548 NA 0.34 5.75 0.3 2.02e-8 Schizophrenia; LUSC cis rs9640161 0.659 rs59572505 chr7:150014986 C/T cg27494647 chr7:150038898 RARRES2 0.46 7.19 0.37 4.31e-12 Blood protein levels;Circulating chemerin levels; LUSC cis rs2281845 0.859 rs1325312 chr1:201079021 A/G cg22815214 chr1:201083145 CACNA1S 0.54 9.27 0.45 2.42e-18 Permanent tooth development; LUSC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg20203395 chr5:56204925 C5orf35 -0.77 -10.24 -0.49 1.4e-21 Initial pursuit acceleration; LUSC trans rs8072100 1.000 rs3809868 chr17:45750596 G/A cg03886242 chr7:26192032 NFE2L3 0.38 6.29 0.33 9.81e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg22823121 chr1:150693482 HORMAD1 0.61 9.34 0.45 1.45e-18 Tonsillectomy; LUSC cis rs9527 0.545 rs7095304 chr10:104954795 G/A cg23093090 chr10:104574429 C10orf26 -0.34 -6.26 -0.32 1.19e-9 Arsenic metabolism; LUSC cis rs908922 0.676 rs528427 chr1:152511507 G/C cg20991723 chr1:152506922 NA 0.51 9.74 0.47 6.76e-20 Hair morphology; LUSC cis rs9300255 0.602 rs1790116 chr12:123618544 G/T cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.37 -6.06 -0.31 3.72e-9 Neutrophil percentage of white cells; LUSC cis rs7572733 0.534 rs7604700 chr2:198718630 A/G cg00792783 chr2:198669748 PLCL1 0.43 5.86 0.31 1.12e-8 Dermatomyositis; LUSC cis rs4974559 0.790 rs5019560 chr4:1324793 G/A cg02980000 chr4:1222292 CTBP1 0.85 9.71 0.47 8.27e-20 Systolic blood pressure; LUSC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg00701064 chr4:6280414 WFS1 -0.58 -14.33 -0.62 1.28e-36 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20418281 chr17:27717751 TAOK1 -0.44 -6.63 -0.34 1.34e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg12011299 chr4:100065546 ADH4 0.71 10.76 0.51 2.23e-23 Smoking initiation; LUSC cis rs782590 0.837 rs782573 chr2:55912961 T/C cg03859395 chr2:55845619 SMEK2 0.85 15.18 0.64 5.99e-40 Metabolic syndrome; LUSC cis rs1775715 0.835 rs113450267 chr10:32223728 G/A cg03015672 chr10:32216066 ARHGAP12 0.32 5.72 0.3 2.31e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg08754478 chr10:133766260 PPP2R2D -0.62 -8.12 -0.41 9.35e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; LUSC cis rs2227564 0.729 rs2688615 chr10:75651499 C/G cg23231163 chr10:75533350 FUT11 -0.43 -5.85 -0.31 1.14e-8 Crohn's disease;Inflammatory bowel disease; LUSC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg23630131 chr7:65973040 NA -0.21 -5.81 -0.3 1.42e-8 Aortic root size; LUSC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg08677398 chr8:58056175 NA 0.43 5.99 0.31 5.47e-9 Developmental language disorder (linguistic errors); LUSC cis rs907612 0.638 rs907613 chr11:1874292 G/A cg07277017 chr11:1874093 LSP1 0.34 6.0 0.31 5.23e-9 Monocyte percentage of white cells;Monocyte count;Granulocyte percentage of myeloid white cells; LUSC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg19130645 chr7:65235666 NA -0.38 -5.89 -0.31 9.67e-9 Calcium levels; LUSC cis rs654950 0.806 rs7550496 chr1:42043834 G/A cg06885757 chr1:42089581 HIVEP3 0.44 8.98 0.44 2e-17 Airway imaging phenotypes; LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg05025164 chr4:1340916 KIAA1530 0.49 7.58 0.38 3.34e-13 Obesity-related traits; LUSC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg09509183 chr1:209979624 IRF6 0.41 6.28 0.33 1.02e-9 Monobrow; LUSC cis rs4253772 0.872 rs45528736 chr22:46638312 A/G cg24881330 chr22:46731750 TRMU 0.63 5.85 0.31 1.15e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs9929218 0.859 rs9936682 chr16:68748223 A/G cg02972257 chr16:68554789 NA 0.45 5.81 0.3 1.46e-8 Colorectal cancer; LUSC cis rs7177699 0.557 rs7164479 chr15:79123054 C/T cg00540400 chr15:79124168 NA 0.43 7.55 0.38 4.3e-13 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.1 -17.14 -0.68 1.07e-47 Gut microbiome composition (summer); LUSC cis rs9443645 0.527 rs9361477 chr6:79710806 C/T cg05283184 chr6:79620031 NA -0.45 -8.61 -0.43 2.94e-16 Intelligence (multi-trait analysis); LUSC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg01475377 chr6:109611718 NA -0.41 -7.26 -0.37 2.69e-12 Reticulocyte fraction of red cells; LUSC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg15448220 chr1:150897856 SETDB1 -0.4 -5.8 -0.3 1.54e-8 Melanoma; LUSC cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg13126279 chr21:47581558 C21orf56 -0.43 -6.34 -0.33 7.62e-10 Testicular germ cell tumor; LUSC cis rs9430161 0.598 rs34350247 chr1:11034460 A/G cg02454025 chr1:11042201 C1orf127 1.02 18.51 0.71 3.88e-53 Ewing sarcoma; LUSC cis rs9807989 0.507 rs6745614 chr2:102991213 A/G cg03938978 chr2:103052716 IL18RAP 0.37 7.1 0.36 7.4e-12 Asthma; LUSC trans rs4689592 0.503 rs10516184 chr4:7060959 C/T cg07817883 chr1:32538562 TMEM39B -0.54 -6.28 -0.32 1.08e-9 Monocyte percentage of white cells; LUSC cis rs1580019 0.961 rs6949851 chr7:32493807 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.77 11.52 0.53 4.56e-26 Cognitive ability; LUSC cis rs8060686 0.641 rs75450962 chr16:68210868 C/T cg05110241 chr16:68378359 PRMT7 -0.57 -6.38 -0.33 5.93e-10 HDL cholesterol;Metabolic syndrome; LUSC cis rs6906287 0.647 rs10457330 chr6:118731468 A/T cg21191810 chr6:118973309 C6orf204 0.33 6.14 0.32 2.39e-9 Electrocardiographic conduction measures; LUSC cis rs7246967 0.551 rs8112442 chr19:22893369 C/T cg23217946 chr19:22817039 ZNF492 0.41 5.7 0.3 2.67e-8 Bronchopulmonary dysplasia; LUSC cis rs7193541 0.684 rs7191665 chr16:74688948 T/G cg01733217 chr16:74700730 RFWD3 0.97 22.15 0.77 1.61e-67 Multiple myeloma; LUSC cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg10518543 chr12:38710700 ALG10B 0.41 5.79 0.3 1.62e-8 Morning vs. evening chronotype; LUSC cis rs8114671 0.836 rs6058154 chr20:33585834 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -5.92 -0.31 7.78e-9 Height; LUSC trans rs13390641 0.614 rs111831581 chr2:104095920 C/A cg03260781 chr1:16346299 HSPB7 -0.46 -6.09 -0.32 3.14e-9 Blood pressure;Blood pressure (anthropometric measures interaction); LUSC cis rs7615316 0.934 rs1129393 chr3:142283813 A/G cg16271453 chr3:142027066 XRN1 -0.36 -6.25 -0.32 1.29e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg08579753 chr1:39174525 NA 0.51 6.19 0.32 1.72e-9 Bipolar disorder and schizophrenia; LUSC cis rs11122272 0.614 rs78172021 chr1:231525160 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.64 -9.99 -0.48 9.49e-21 Hemoglobin concentration; LUSC cis rs9486719 1.000 rs34209750 chr6:96882215 G/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.89 -0.48 2.15e-20 Migraine;Coronary artery disease; LUSC cis rs3768617 0.510 rs723014 chr1:183076287 A/G ch.1.3577855R chr1:183094577 LAMC1 0.71 10.83 0.51 1.26e-23 Fuchs's corneal dystrophy; LUSC cis rs5766691 0.644 rs6007607 chr22:47529288 C/G cg15757745 chr22:47558489 TBC1D22A -0.63 -10.03 -0.48 7.27e-21 Longevity; LUSC cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg07606381 chr6:8435919 SLC35B3 -0.83 -12.5 -0.56 1.12e-29 Motion sickness; LUSC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg22166914 chr1:53195759 ZYG11B -0.4 -5.96 -0.31 6.31e-9 Monocyte count; LUSC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.64 -0.3 3.57e-8 Breast cancer; LUSC cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg23711669 chr6:146136114 FBXO30 0.78 13.66 0.6 4.51e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs9300255 0.679 rs4759409 chr12:123719585 G/C cg05973401 chr12:123451056 ABCB9 0.52 6.53 0.34 2.39e-10 Neutrophil percentage of white cells; LUSC cis rs8017423 0.967 rs17188605 chr14:90722579 C/T cg14092571 chr14:90743983 NA -0.36 -5.86 -0.31 1.11e-8 Mortality in heart failure; LUSC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.5 8.69 0.43 1.66e-16 Prudent dietary pattern; LUSC cis rs7914558 1.000 rs10786740 chr10:104935593 G/C cg05855489 chr10:104503620 C10orf26 0.59 9.52 0.46 3.66e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg15605315 chr1:45957053 TESK2 0.46 7.33 0.37 1.78e-12 High light scatter reticulocyte count; LUSC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg06558623 chr16:89946397 TCF25 1.11 9.74 0.47 6.79e-20 Skin colour saturation; LUSC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg05863683 chr7:1912471 MAD1L1 0.3 5.77 0.3 1.8e-8 Bipolar disorder and schizophrenia; LUSC cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg25173405 chr17:45401733 C17orf57 0.39 6.2 0.32 1.65e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1865760 0.516 rs9295684 chr6:26069669 T/C cg16482183 chr6:26056742 HIST1H1C 0.56 8.47 0.42 7.76e-16 Height; LUSC cis rs7945718 0.967 rs4757945 chr11:12808718 A/G cg25843174 chr11:12811716 TEAD1 -0.35 -7.76 -0.39 1.05e-13 Educational attainment (years of education); LUSC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg26727032 chr16:67993705 SLC12A4 -0.43 -5.8 -0.3 1.5e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs7617480 0.648 rs9882443 chr3:48749064 G/A cg07636037 chr3:49044803 WDR6 0.79 10.27 0.49 1.12e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg12311346 chr5:56204834 C5orf35 -0.95 -13.54 -0.6 1.33e-33 Initial pursuit acceleration; LUSC cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg03146154 chr1:46216737 IPP 0.56 8.35 0.42 1.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg06484146 chr7:12443880 VWDE -0.74 -7.61 -0.38 2.77e-13 Coronary artery disease; LUSC cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg05347473 chr6:146136440 FBXO30 0.53 9.11 0.45 7.97e-18 Lobe attachment (rater-scored or self-reported); LUSC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03517284 chr6:25882590 NA -0.64 -11.21 -0.52 5.94e-25 Blood metabolite levels; LUSC cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg06108461 chr20:60628389 TAF4 -0.93 -15.59 -0.65 1.53e-41 Body mass index; LUSC cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg13010199 chr12:38710504 ALG10B 0.69 10.65 0.5 5.27e-23 Bladder cancer; LUSC cis rs4951018 0.853 rs1573104 chr1:205636907 A/C cg26354017 chr1:205819088 PM20D1 -0.41 -5.95 -0.31 6.93e-9 Prostate-specific antigen levels; LUSC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg20302533 chr7:39170763 POU6F2 0.57 9.46 0.46 5.77e-19 IgG glycosylation; LUSC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -10.19 -0.49 2.11e-21 Developmental language disorder (linguistic errors); LUSC cis rs1256061 0.624 rs1256046 chr14:64729356 A/C cg23250157 chr14:64679961 SYNE2 0.32 5.7 0.3 2.68e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; LUSC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg21573476 chr21:45109991 RRP1B 0.39 6.4 0.33 5.37e-10 Mean corpuscular volume; LUSC cis rs1595825 0.786 rs73054839 chr2:198671665 C/A cg10547527 chr2:198650123 BOLL -0.52 -5.97 -0.31 5.91e-9 Ulcerative colitis; LUSC cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg22437258 chr11:111473054 SIK2 0.49 6.33 0.33 8.08e-10 Primary sclerosing cholangitis; LUSC cis rs6693567 0.565 rs471738 chr1:150276429 G/A cg15654264 chr1:150340011 RPRD2 -0.45 -7.44 -0.38 8.42e-13 Migraine; LUSC cis rs9309473 0.607 rs6716776 chr2:73587713 T/C cg20560298 chr2:73613845 ALMS1 -0.55 -8.24 -0.41 3.84e-15 Metabolite levels; LUSC trans rs7838490 0.780 rs35716194 chr8:89678635 C/T cg24558378 chr1:183589673 NA 0.34 6.17 0.32 2e-9 Body mass index and cholesterol (psychopharmacological treatment); LUSC cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg06552810 chr11:31128660 NA 0.4 7.16 0.36 5.04e-12 Red blood cell count; LUSC cis rs9296092 0.538 rs62405943 chr6:33517359 A/G cg13560919 chr6:33536144 NA -0.81 -15.57 -0.65 1.72e-41 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg11887960 chr12:57824829 NA 0.55 7.24 0.37 3.18e-12 Lung disease severity in cystic fibrosis; LUSC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.83 0.35 4.07e-11 Intelligence (multi-trait analysis); LUSC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg21770322 chr7:97807741 LMTK2 0.4 7.06 0.36 9.83e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs514406 0.763 rs7535088 chr1:53215042 A/G cg24675658 chr1:53192096 ZYG11B 0.6 9.4 0.46 9.2e-19 Monocyte count; LUSC cis rs7561273 0.545 rs10865262 chr2:24337594 A/G cg08063864 chr2:24346004 PFN4;LOC375190 0.42 6.02 0.31 4.54e-9 Quantitative traits; LUSC cis rs6939532 0.544 rs10946816 chr6:26361946 C/G cg05738196 chr6:26577821 NA -0.41 -5.66 -0.3 3.19e-8 Autism spectrum disorder or schizophrenia; LUSC cis rs7267979 0.966 rs2482918 chr20:25412135 C/T cg08601574 chr20:25228251 PYGB -0.45 -6.89 -0.35 2.73e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs7659604 0.540 rs67150579 chr4:122704331 T/A cg20573242 chr4:122745356 CCNA2 -0.46 -6.75 -0.35 6.61e-11 Type 2 diabetes; LUSC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg17366294 chr4:99064904 C4orf37 0.56 9.77 0.47 5.22e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs1018836 0.608 rs10094978 chr8:91509054 C/T cg16814680 chr8:91681699 NA -0.63 -9.42 -0.46 7.95e-19 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg26597838 chr10:835615 NA 0.83 11.57 0.54 2.8e-26 Eosinophil percentage of granulocytes; LUSC cis rs208520 0.690 rs1318604 chr6:66825278 A/C cg07460842 chr6:66804631 NA -1.15 -18.29 -0.71 2.9e-52 Exhaled nitric oxide output; LUSC cis rs1997103 1.000 rs2331065 chr7:55408392 A/G cg17469321 chr7:55412551 NA 0.65 10.6 0.5 7.9399999999999994e-23 QRS interval (sulfonylurea treatment interaction); LUSC cis rs611744 0.550 rs57045491 chr8:109279120 A/C cg18478394 chr8:109455254 TTC35 0.42 6.53 0.34 2.38e-10 Dupuytren's disease; LUSC cis rs73200209 0.744 rs61937384 chr12:116698606 G/C cg01776926 chr12:116560359 MED13L -0.48 -5.88 -0.31 1.01e-8 Total body bone mineral density; LUSC cis rs12421382 0.659 rs56410856 chr11:109382455 T/G cg27471124 chr11:109292789 C11orf87 0.41 7.22 0.37 3.52e-12 Schizophrenia; LUSC cis rs644799 0.601 rs7902 chr11:95565288 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.69 11.19 0.52 6.57e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg09034736 chr1:150693464 HORMAD1 0.5 7.3 0.37 2.18e-12 Tonsillectomy; LUSC cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg27129171 chr3:47204927 SETD2 0.7 11.65 0.54 1.47e-26 Colorectal cancer; LUSC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg18758796 chr5:131593413 PDLIM4 0.43 6.93 0.35 2.22e-11 Breast cancer; LUSC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg09436375 chr6:42928200 GNMT -0.29 -6.73 -0.35 7.54e-11 Alzheimer's disease in APOE e4+ carriers; LUSC cis rs6939532 0.597 rs2273558 chr6:26466035 A/C cg05738196 chr6:26577821 NA -0.5 -7.11 -0.36 7.18e-12 Autism spectrum disorder or schizophrenia; LUSC cis rs2439831 1.000 rs550239 chr15:43720197 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.98 11.3 0.53 2.63e-25 Lung cancer in ever smokers; LUSC cis rs1044826 0.642 rs4607068 chr3:139162994 A/G cg15131784 chr3:139108705 COPB2 0.42 6.85 0.35 3.55e-11 Obesity-related traits; LUSC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg11245181 chr6:149772854 ZC3H12D -0.33 -7.09 -0.36 7.79e-12 Dupuytren's disease; LUSC cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg13395646 chr4:1353034 KIAA1530 0.49 7.0 0.36 1.44e-11 Obesity-related traits; LUSC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 10.87 0.51 8.89e-24 Hip circumference adjusted for BMI; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24465448 chr8:17942444 ASAH1 -0.41 -6.31 -0.33 9.02e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg03929089 chr4:120376271 NA 0.82 11.17 0.52 7.89e-25 Height; LUSC trans rs8002861 0.870 rs4942251 chr13:44440048 G/T cg12856521 chr11:46389249 DGKZ 0.42 6.69 0.34 9.32e-11 Leprosy; LUSC cis rs6840360 0.554 rs4643789 chr4:152726691 C/T cg22705602 chr4:152727874 NA -0.38 -7.88 -0.4 4.71e-14 Intelligence (multi-trait analysis); LUSC cis rs4363385 0.818 rs2152994 chr1:152991060 C/T cg00922841 chr1:152955080 SPRR1A 0.44 7.68 0.39 1.82e-13 Inflammatory skin disease; LUSC cis rs7202877 0.706 rs8054586 chr16:75410705 G/C cg03315344 chr16:75512273 CHST6 0.42 6.18 0.32 1.87e-9 Type 2 diabetes;Type 1 diabetes; LUSC cis rs10788972 0.873 rs4926619 chr1:54558101 A/G cg25741118 chr1:54482237 LDLRAD1 -0.27 -5.89 -0.31 9.58e-9 Parkinson disease and lewy body pathology; LUSC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg01420254 chr6:26195488 NA 0.64 7.05 0.36 1.01e-11 Gout;Renal underexcretion gout; LUSC trans rs2797160 1.000 rs2747717 chr6:126008435 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs11190604 0.945 rs2495746 chr10:102328270 T/C cg07080220 chr10:102295463 HIF1AN 0.67 9.26 0.45 2.5e-18 Palmitoleic acid (16:1n-7) levels; LUSC cis rs12760731 0.641 rs11590951 chr1:178322757 C/T cg00404053 chr1:178313656 RASAL2 0.57 6.04 0.31 4.13e-9 Obesity-related traits; LUSC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg00343986 chr7:65444356 GUSB 0.43 6.56 0.34 2.07e-10 Aortic root size; LUSC cis rs41271951 0.512 rs6664387 chr1:151021509 A/G cg11822372 chr1:151115635 SEMA6C -0.78 -7.16 -0.36 5.06e-12 Blood protein levels; LUSC cis rs1018836 0.631 rs2205157 chr8:91472384 C/T cg16814680 chr8:91681699 NA -0.56 -8.24 -0.41 4.09e-15 Ejection fraction in Tripanosoma cruzi seropositivity; LUSC cis rs34684276 1 rs34684276 chr15:78813155 G/A cg18825076 chr15:78729989 IREB2 -0.54 -8.58 -0.42 3.62e-16 Nicotine dependence;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1/FVC ratio in COPD; LUSC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg24550644 chr17:30846204 MYO1D -0.37 -5.81 -0.3 1.49e-8 Schizophrenia; LUSC trans rs4332037 0.802 rs73048106 chr7:1929019 G/T cg11693508 chr17:37793320 STARD3 0.66 7.61 0.38 2.78e-13 Bipolar disorder; LUSC cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg22455342 chr2:225449267 CUL3 0.8 10.96 0.51 4.41e-24 IgE levels in asthmatics (D.p. specific); LUSC trans rs9329221 0.507 rs12678938 chr8:10016969 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -7.71 -0.39 1.47e-13 Neuroticism; LUSC cis rs66887589 0.560 rs9684327 chr4:120365441 A/G cg24375607 chr4:120327624 NA 0.49 7.56 0.38 3.87e-13 Diastolic blood pressure; LUSC cis rs6754311 0.689 rs191079 chr2:136633771 T/C cg07169764 chr2:136633963 MCM6 0.57 7.71 0.39 1.49e-13 Mosquito bite size; LUSC cis rs9811920 0.809 rs6440967 chr3:99722396 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.36 6.61 0.34 1.54e-10 Axial length; LUSC cis rs265548 0.510 rs28415068 chr19:17910582 T/A cg21960279 chr19:17905606 B3GNT3 0.38 5.78 0.3 1.71e-8 Tumor biomarkers; LUSC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg23172400 chr8:95962367 TP53INP1 -0.45 -9.48 -0.46 4.92e-19 Type 2 diabetes; LUSC cis rs2580764 0.624 rs12713284 chr2:55228861 G/A cg09592903 chr2:55203963 RTN4 -0.49 -10.09 -0.48 4.58e-21 Mean platelet volume; LUSC cis rs7107174 0.786 rs4945269 chr11:78047077 A/G cg27205649 chr11:78285834 NARS2 -0.51 -5.83 -0.3 1.33e-8 Testicular germ cell tumor; LUSC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 7.89 0.4 4.26e-14 Bipolar disorder; LUSC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg06671660 chr6:41068741 NFYA;LOC221442 -0.4 -5.65 -0.3 3.4e-8 Alzheimer's disease (late onset); LUSC cis rs2439831 0.867 rs2264876 chr15:43757419 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.99 11.46 0.53 7.03e-26 Lung cancer in ever smokers; LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg07507251 chr3:52567010 NT5DC2 0.32 6.13 0.32 2.44e-9 Bipolar disorder; LUSC cis rs941408 0.515 rs12610096 chr19:2778129 C/T cg02580895 chr19:2754563 NA -0.46 -6.79 -0.35 5.11e-11 Total cholesterol levels; LUSC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg07716408 chr11:68623521 NA 0.32 6.33 0.33 7.67e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg19346786 chr7:2764209 NA -0.5 -8.63 -0.43 2.62e-16 Height; LUSC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg15112475 chr7:1198522 ZFAND2A -0.34 -7.21 -0.37 3.68e-12 Longevity;Endometriosis; LUSC cis rs9875589 0.509 rs1488377 chr3:14073178 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.37 6.13 0.32 2.41e-9 Ovarian reserve; LUSC trans rs61931739 0.500 rs34167298 chr12:34534338 G/A cg13010199 chr12:38710504 ALG10B 0.67 10.52 0.5 1.56e-22 Morning vs. evening chronotype; LUSC cis rs983392 0.667 rs634475 chr11:59942081 G/A cg02771260 chr11:59836817 MS4A3 0.37 6.28 0.33 1.03e-9 Alzheimer's disease (late onset); LUSC cis rs4689388 0.926 rs4688987 chr4:6287329 C/T cg14416269 chr4:6271139 WFS1 0.54 11.65 0.54 1.5e-26 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg17968037 chr7:100024898 ZCWPW1 -0.42 -6.1 -0.32 2.9e-9 Platelet count; LUSC cis rs9311676 0.656 rs4681682 chr3:58337833 A/G cg26110898 chr3:58419937 PDHB -0.43 -6.95 -0.36 1.91e-11 Systemic lupus erythematosus; LUSC cis rs73591976 0.539 rs12446198 chr16:68125972 G/A cg09835421 chr16:68378352 PRMT7 -0.56 -6.23 -0.32 1.39e-9 HDL cholesterol; LUSC cis rs870825 0.932 rs28702958 chr4:185575562 C/T cg04058563 chr4:185651563 MLF1IP 0.84 11.24 0.52 4.52e-25 Blood protein levels; LUSC cis rs12980942 0.872 rs12985339 chr19:41801756 A/T cg25627403 chr19:41769009 HNRNPUL1 -0.61 -6.58 -0.34 1.79e-10 Coronary artery disease; LUSC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg23758822 chr17:41437982 NA 1.05 19.04 0.72 3.07e-55 Menopause (age at onset); LUSC cis rs7572733 0.555 rs7561950 chr2:198754244 C/T cg00792783 chr2:198669748 PLCL1 0.45 6.1 0.32 2.89e-9 Dermatomyositis; LUSC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg22532475 chr10:104410764 TRIM8 0.28 5.71 0.3 2.49e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg08470875 chr2:26401718 FAM59B 0.7 9.08 0.44 9.74e-18 Gut microbiome composition (summer); LUSC cis rs2404602 0.684 rs4886816 chr15:76874707 A/C cg23625390 chr15:77176239 SCAPER -0.65 -9.99 -0.48 9.5e-21 Blood metabolite levels; LUSC cis rs9322193 0.962 rs2275046 chr6:150157001 A/G cg07701084 chr6:150067640 NUP43 0.52 7.58 0.38 3.51e-13 Lung cancer; LUSC cis rs12579753 0.879 rs11115002 chr12:82153090 C/T cg21231944 chr12:82153410 PPFIA2 -0.4 -6.2 -0.32 1.63e-9 Resting heart rate; LUSC cis rs7589342 0.839 rs12997003 chr2:106436413 C/T cg14210321 chr2:106509881 NCK2 -0.53 -7.94 -0.4 3.11e-14 Addiction; LUSC cis rs7613051 0.580 rs11720449 chr3:33066467 C/T cg19000631 chr3:33138515 GLB1;TMPPE 0.61 6.43 0.33 4.31e-10 Atopic dermatitis; LUSC cis rs12776158 0.901 rs57677741 chr10:71217131 G/A cg12610070 chr10:71211762 TSPAN15 -0.46 -5.91 -0.31 8.46e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs7193541 0.965 rs7199068 chr16:74698263 C/G cg01733217 chr16:74700730 RFWD3 0.88 15.49 0.65 3.75e-41 Multiple myeloma; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg12328890 chr11:706098 EPS8L2 -0.45 -7.27 -0.37 2.63e-12 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC trans rs72674100 1.000 rs10027971 chr4:97967340 T/C cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs16854884 0.741 rs55909524 chr3:143794734 T/C cg06585982 chr3:143692056 C3orf58 0.44 6.47 0.33 3.44e-10 Economic and political preferences (feminism/equality); LUSC cis rs897080 0.553 rs1067338 chr2:44624708 G/A cg00619915 chr2:44497795 NA -0.39 -5.65 -0.3 3.45e-8 Height; LUSC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg05855489 chr10:104503620 C10orf26 -0.68 -10.23 -0.49 1.51e-21 Allergic disease (asthma, hay fever or eczema); LUSC trans rs11098499 0.821 rs28665282 chr4:120384186 C/T cg25214090 chr10:38739885 LOC399744 0.57 8.42 0.42 1.14e-15 Corneal astigmatism; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg23883215 chr8:26240324 BNIP3L -0.42 -5.99 -0.31 5.3e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg05855489 chr10:104503620 C10orf26 -0.64 -7.79 -0.39 8.46e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs11711311 0.955 rs12630833 chr3:113390883 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -6.23 -0.32 1.44e-9 IgG glycosylation; LUSC cis rs10493773 0.618 rs34746573 chr1:86075360 G/A cg17807903 chr1:86174739 ZNHIT6 -0.39 -7.65 -0.39 2.24e-13 Urate levels in overweight individuals; LUSC cis rs2455601 0.786 rs2568068 chr11:8977830 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -6.08 -0.32 3.22e-9 Schizophrenia; LUSC cis rs73206853 0.563 rs9300316 chr12:111196204 T/C cg12870014 chr12:110450643 ANKRD13A 0.67 6.98 0.36 1.56e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs2762353 0.935 rs2817188 chr6:25807603 A/G cg03517284 chr6:25882590 NA -0.43 -7.74 -0.39 1.19e-13 Blood metabolite levels; LUSC cis rs66569888 0.507 rs11673736 chr2:106886935 T/C cg16099169 chr2:106886729 NA -0.45 -6.64 -0.34 1.24e-10 Facial morphology (factor 23); LUSC cis rs6066835 0.867 rs11698214 chr20:47359603 G/A cg18078177 chr20:47281410 PREX1 0.65 5.76 0.3 1.93e-8 Multiple myeloma; LUSC cis rs929354 0.685 rs7807856 chr7:156934498 T/C cg17757837 chr7:157058334 UBE3C 0.82 12.98 0.58 1.8e-31 Body mass index; LUSC cis rs7818345 1.000 rs7818345 chr8:19306618 T/C cg11303988 chr8:19266685 CSGALNACT1 0.35 6.48 0.33 3.34e-10 Language performance in older adults (adjusted for episodic memory); LUSC cis rs709400 0.567 rs1961600 chr14:103862144 G/A cg10523860 chr14:103875565 MARK3 -0.4 -6.44 -0.33 4.18e-10 Body mass index; LUSC cis rs500891 0.547 rs2152183 chr6:84102879 A/C cg08257003 chr6:84140564 ME1 -0.32 -7.21 -0.37 3.7e-12 Platelet-derived growth factor BB levels; LUSC cis rs34330 0.562 rs7486387 chr12:12866911 G/A cg04607235 chr12:12878440 APOLD1 -0.53 -6.0 -0.31 5.17e-9 Systemic lupus erythematosus; LUSC cis rs6558174 0.965 rs2003908 chr8:22491518 T/C cg03733263 chr8:22462867 KIAA1967 0.46 6.08 0.32 3.27e-9 Breast cancer; LUSC trans rs6924906 0.655 rs74548211 chr6:82238149 C/A cg15052890 chr17:4636830 MED11;CXCL16 -0.58 -6.12 -0.32 2.57e-9 Blood pressure; LUSC cis rs7481584 0.624 rs511990 chr11:3052936 A/G cg25174290 chr11:3078921 CARS -0.41 -6.14 -0.32 2.33e-9 Calcium levels; LUSC cis rs4363385 0.765 rs3806221 chr1:153002555 G/T cg00922841 chr1:152955080 SPRR1A -0.45 -7.9 -0.4 4e-14 Inflammatory skin disease; LUSC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.17 0.32 2.03e-9 Height; LUSC cis rs155346 1.000 rs265152 chr5:139379707 C/T cg01090482 chr5:139365336 NRG2 -0.36 -6.08 -0.32 3.2e-9 Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia; LUSC trans rs61931739 0.929 rs1490110 chr12:34091605 A/G cg13010199 chr12:38710504 ALG10B -0.46 -7.18 -0.37 4.69e-12 Morning vs. evening chronotype; LUSC cis rs2282300 0.739 rs16920406 chr11:30216158 A/C cg25418670 chr11:30344373 C11orf46 -0.62 -9.01 -0.44 1.56e-17 Morning vs. evening chronotype; LUSC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg23985595 chr17:80112537 CCDC57 0.31 5.9 0.31 8.94e-9 Life satisfaction; LUSC cis rs6690583 0.697 rs4907126 chr1:85523453 C/T cg11262906 chr1:85462892 MCOLN2 0.53 6.79 0.35 5.16e-11 Serum sulfate level; LUSC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg21361702 chr7:150065534 REPIN1 0.5 6.7 0.34 8.83e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs4243830 0.850 rs7540913 chr1:6581877 C/T cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.98 -0.36 1.57e-11 Body mass index; LUSC cis rs4285028 0.747 rs4048699 chr3:121404483 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.88 12.83 0.57 6.63e-31 Multiple sclerosis; LUSC cis rs7208859 0.623 rs73267858 chr17:29059737 A/G cg13385521 chr17:29058706 SUZ12P 0.71 7.06 0.36 9.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg05347473 chr6:146136440 FBXO30 0.56 9.55 0.46 2.83e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs7917772 0.582 rs11191352 chr10:104372244 A/G cg05855489 chr10:104503620 C10orf26 -0.48 -7.35 -0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs4077468 1.000 rs11801695 chr1:205916175 A/C cg14893161 chr1:205819251 PM20D1 0.42 6.15 0.32 2.23e-9 Cystic fibrosis-related diabetes; LUSC cis rs7192380 1.000 rs8049728 chr16:69654790 G/T cg26679644 chr16:69762563 NA 0.34 6.14 0.32 2.41e-9 Sjögren's syndrome; LUSC cis rs6076065 1.000 rs2424538 chr20:23382076 A/G cg11657817 chr20:23433608 CST11 0.44 8.66 0.43 2.12e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg15445000 chr17:37608096 MED1 0.39 6.68 0.34 9.76e-11 Glomerular filtration rate (creatinine); LUSC trans rs2840044 1.000 rs8073935 chr17:33985849 C/T cg19694781 chr19:47549865 TMEM160 -0.56 -8.93 -0.44 2.8e-17 Response to radiotherapy in cancer (late toxicity); LUSC cis rs394563 0.810 rs480870 chr6:149784818 T/C cg07828024 chr6:149772892 ZC3H12D -0.37 -7.87 -0.4 4.99e-14 Dupuytren's disease; LUSC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg05785598 chr3:49045655 WDR6 0.34 5.7 0.3 2.68e-8 Parkinson's disease; LUSC cis rs1163251 0.837 rs595283 chr1:120247887 C/G cg19096424 chr1:120255104 PHGDH -0.46 -6.18 -0.32 1.86e-9 Blood metabolite levels; LUSC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.89 12.84 0.57 5.85e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11048434 0.736 rs2377672 chr12:9112414 A/G cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 1.02e-8 Sjögren's syndrome; LUSC trans rs853679 0.545 rs35949109 chr6:28025926 T/C cg06606381 chr12:133084897 FBRSL1 -0.69 -7.17 -0.37 4.79e-12 Depression; LUSC cis rs3768617 0.510 rs12061219 chr1:183101471 G/A ch.1.3577855R chr1:183094577 LAMC1 0.73 11.25 0.52 4.16e-25 Fuchs's corneal dystrophy; LUSC cis rs5769765 1.000 rs5769760 chr22:50259696 A/G cg08270630 chr22:50330655 NA 0.4 5.89 0.31 9.67e-9 Schizophrenia; LUSC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg24675658 chr1:53192096 ZYG11B 0.73 12.09 0.55 3.83e-28 Monocyte count; LUSC trans rs7824557 0.545 rs34482136 chr8:11227885 C/T cg06636001 chr8:8085503 FLJ10661 -0.57 -8.46 -0.42 8.3e-16 Retinal vascular caliber; LUSC cis rs11098499 0.909 rs35165976 chr4:120325630 G/A cg09307838 chr4:120376055 NA 0.77 11.21 0.52 5.88e-25 Corneal astigmatism; LUSC cis rs7617480 0.587 rs9311431 chr3:48848787 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.64 9.32 0.45 1.59e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs1595825 0.891 rs16866940 chr2:198509058 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -5.78 -0.3 1.69e-8 Ulcerative colitis; LUSC cis rs1124376 1.000 rs4417886 chr3:20108511 C/T cg05072819 chr3:20081367 KAT2B 0.61 6.63 0.34 1.37e-10 Bipolar disorder and schizophrenia; LUSC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.97 -0.31 6.04e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg03465714 chr1:152285911 FLG -0.36 -6.27 -0.32 1.13e-9 Inflammatory skin disease; LUSC cis rs10276381 0.786 rs28430601 chr7:28238811 A/G cg23620719 chr7:28220237 JAZF1 0.67 6.87 0.35 3.25e-11 Crohn's disease; LUSC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg26314531 chr2:26401878 FAM59B -0.67 -9.12 -0.45 7.08e-18 Gut microbiome composition (summer); LUSC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg11645453 chr3:52864694 ITIH4 0.34 7.8 0.39 8.14e-14 Bipolar disorder; LUSC trans rs17407555 0.633 rs6836916 chr4:10277792 C/G cg03926050 chr12:111020225 PPTC7 0.4 6.4 0.33 5.3e-10 Schizophrenia (age at onset); LUSC trans rs7824557 0.585 rs2572385 chr8:11208903 G/A cg15556689 chr8:8085844 FLJ10661 0.55 7.97 0.4 2.54e-14 Retinal vascular caliber; LUSC trans rs4713118 0.586 rs9468290 chr6:28087674 C/T cg06606381 chr12:133084897 FBRSL1 -0.47 -6.22 -0.32 1.5e-9 Parkinson's disease; LUSC trans rs9929218 0.906 rs33965787 chr16:68828173 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -10.8 -0.51 1.57e-23 Colorectal cancer; LUSC cis rs7523273 0.606 rs2724398 chr1:207993699 A/G cg22525895 chr1:207977042 MIR29B2 -0.41 -6.56 -0.34 2.01e-10 Schizophrenia; LUSC cis rs4481887 0.676 rs28684663 chr1:248548325 T/C cg26353448 chr1:248524236 OR2T4 -0.3 -5.66 -0.3 3.32e-8 Common traits (Other); LUSC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg02359409 chr6:42947317 PEX6 -0.37 -5.73 -0.3 2.22e-8 Alzheimer's disease in APOE e4+ carriers; LUSC trans rs2797160 1.000 rs2747719 chr6:126009214 C/T cg05039488 chr6:79577232 IRAK1BP1 0.46 6.9 0.35 2.57e-11 Endometrial cancer; LUSC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg06212747 chr3:49208901 KLHDC8B 0.43 5.79 0.3 1.65e-8 Parkinson's disease; LUSC cis rs4780355 0.918 rs243318 chr16:11358018 G/A cg00044050 chr16:11439710 C16orf75 0.57 8.55 0.42 4.38e-16 Crohn's disease and psoriasis; LUSC cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg18681998 chr4:17616180 MED28 0.86 15.71 0.65 4.78e-42 Parasitemia in Tripanosoma cruzi seropositivity; LUSC cis rs6912958 0.677 rs111990232 chr6:88022240 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.46 8.48 0.42 7.35e-16 Monocyte percentage of white cells; LUSC trans rs429017 0.541 rs432902 chr5:41273953 A/G cg17064250 chr6:45388500 RUNX2 0.32 6.15 0.32 2.23e-9 Blood protein levels; LUSC cis rs7809950 0.678 rs62483640 chr7:106900214 T/G cg23024343 chr7:107201750 COG5 -0.66 -10.02 -0.48 7.73e-21 Coronary artery disease; LUSC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -8.32 -0.41 2.23e-15 Hemoglobin concentration; LUSC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg24531977 chr5:56204891 C5orf35 -0.98 -14.54 -0.62 1.92e-37 Initial pursuit acceleration; LUSC cis rs9388451 1.000 rs9388451 chr6:126090377 A/G cg10911889 chr6:126070802 HEY2 0.43 6.62 0.34 1.47e-10 Brugada syndrome; LUSC cis rs4727027 0.704 rs7787753 chr7:148901779 A/T cg14690467 chr7:148917905 ZNF282 -0.26 -5.7 -0.3 2.69e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg01483505 chr11:975446 AP2A2 0.42 5.89 0.31 9.68e-9 Alzheimer's disease (late onset); LUSC trans rs225245 0.782 rs178649 chr17:33908197 C/G cg19694781 chr19:47549865 TMEM160 -0.42 -6.65 -0.34 1.18e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; LUSC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg16325326 chr1:53192061 ZYG11B 0.81 14.13 0.61 7.58e-36 Monocyte count; LUSC trans rs4650994 0.544 rs2811306 chr1:178599248 C/G cg05059571 chr16:84539110 KIAA1609 0.47 8.85 0.44 5.31e-17 HDL cholesterol levels;HDL cholesterol; LUSC cis rs7834588 0.526 rs7008796 chr8:63866789 C/A cg20602954 chr8:63776762 NKAIN3 0.37 5.67 0.3 3.07e-8 Response to Vitamin E supplementation; LUSC cis rs6840360 0.539 rs1443087 chr4:152450095 C/A cg20465933 chr4:152376761 FAM160A1 0.32 5.77 0.3 1.85e-8 Intelligence (multi-trait analysis); LUSC cis rs9650315 0.514 rs13258040 chr8:57207208 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.71 0.39 1.44e-13 Height; LUSC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg06815965 chr1:205818668 PM20D1 0.39 5.96 0.31 6.47e-9 Menarche (age at onset); LUSC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11890956 chr21:40555474 PSMG1 0.74 12.27 0.56 8.2e-29 Cognitive function; LUSC trans rs459571 0.959 rs2520099 chr9:136918139 T/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.72 -12.18 -0.55 1.65e-28 Platelet distribution width; LUSC cis rs6723108 0.651 rs6724774 chr2:135407285 C/T cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Type 2 diabetes; LUSC cis rs59698941 0.943 rs57045911 chr5:132272311 T/C cg02081065 chr5:132209139 LEAP2 -0.63 -6.35 -0.33 7.02e-10 Apolipoprotein A-IV levels; LUSC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -5.8 -0.3 1.51e-8 Major depressive disorder; LUSC cis rs9325144 0.600 rs10785621 chr12:38744912 C/T cg13010199 chr12:38710504 ALG10B 0.48 7.4 0.38 1.13e-12 Morning vs. evening chronotype; LUSC cis rs2932538 0.961 rs4838960 chr1:113163632 G/T cg22162597 chr1:113214053 CAPZA1 -0.53 -7.56 -0.38 3.8e-13 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; LUSC trans rs2243480 1.000 rs316331 chr7:65604622 A/G cg10756647 chr7:56101905 PSPH -0.95 -8.91 -0.44 3.32e-17 Diabetic kidney disease; LUSC cis rs9296092 0.517 rs11751684 chr6:33528739 G/T cg13560919 chr6:33536144 NA -0.85 -16.4 -0.67 9.02e-45 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC cis rs11608355 0.521 rs6606706 chr12:109830173 C/T cg19025524 chr12:109796872 NA -0.4 -7.5 -0.38 6e-13 Neuroticism; LUSC trans rs12637928 0.560 rs35372780 chr3:110154651 A/T cg17371621 chr15:61264283 RORA 0.38 6.45 0.33 3.84e-10 Neuroticism; LUSC cis rs10832963 1.000 rs10832962 chr11:18656271 C/T cg20219074 chr11:18656078 SPTY2D1 0.73 10.97 0.51 3.96e-24 Breast cancer; LUSC cis rs7666738 0.515 rs28615369 chr4:98896858 C/T cg03676636 chr4:99064102 C4orf37 0.31 6.25 0.32 1.27e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs208520 0.608 rs3846803 chr6:66805743 C/A cg07460842 chr6:66804631 NA -1.13 -17.93 -0.7 7.53e-51 Exhaled nitric oxide output; LUSC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg18252515 chr7:66147081 NA -1.24 -13.9 -0.61 5.54e-35 Diabetic kidney disease; LUSC cis rs34638657 0.872 rs2967350 chr16:82196130 T/C cg09439754 chr16:82129088 HSD17B2 -0.39 -6.36 -0.33 6.64e-10 Lung adenocarcinoma; LUSC cis rs6714710 0.627 rs6748124 chr2:98519014 T/C cg26665480 chr2:98280029 ACTR1B 0.58 8.56 0.42 4.18e-16 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg22963979 chr7:1858916 MAD1L1 0.54 8.15 0.41 7.55e-15 Bipolar disorder and schizophrenia; LUSC trans rs8072100 0.875 rs12451409 chr17:45544856 A/G cg04995722 chr7:26192034 NFE2L3 -0.43 -6.59 -0.34 1.68e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg20203395 chr5:56204925 C5orf35 -0.45 -6.67 -0.34 1.09e-10 Coronary artery disease; LUSC cis rs8058578 1.000 rs67456513 chr16:30714828 A/T cg05768032 chr16:30646687 NA 0.4 5.96 0.31 6.32e-9 Multiple myeloma; LUSC cis rs6714710 0.603 rs10432626 chr2:98561153 C/A cg26665480 chr2:98280029 ACTR1B 0.58 8.43 0.42 1.04e-15 Posterior cortical atrophy and Alzheimer's disease; LUSC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg10729496 chr3:10149963 C3orf24 0.58 7.45 0.38 7.84e-13 Alzheimer's disease; LUSC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg19748678 chr4:122722346 EXOSC9 0.49 7.53 0.38 4.64e-13 Type 2 diabetes; LUSC cis rs7584330 0.704 rs7602387 chr2:238356795 A/G cg16989719 chr2:238392110 NA -0.36 -6.26 -0.32 1.16e-9 Prostate cancer; LUSC cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg06064525 chr11:970664 AP2A2 -0.49 -10.73 -0.51 2.85e-23 Alzheimer's disease (late onset); LUSC cis rs6582630 0.598 rs10880645 chr12:38556172 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.27 -0.41 3.22e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs2692947 0.860 rs2579520 chr2:96660300 C/T cg23100626 chr2:96804247 ASTL -0.22 -5.67 -0.3 3.06e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC trans rs2018683 0.624 rs2286219 chr7:28998663 G/A cg19402173 chr7:128379420 CALU -0.51 -7.55 -0.38 4.11e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; LUSC cis rs17253792 0.822 rs2296181 chr14:56107051 G/A cg01858014 chr14:56050164 KTN1 -0.84 -6.78 -0.35 5.6e-11 Putamen volume; LUSC cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -7.01 -0.36 1.32e-11 Menopause (age at onset); LUSC cis rs10992471 0.729 rs7042335 chr9:95122547 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.47 -8.0 -0.4 2.01e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs6495367 0.898 rs2049176 chr15:79392548 A/C cg17916960 chr15:79447300 NA 0.41 7.64 0.39 2.38e-13 Spherical equivalent (joint analysis main effects and education interaction); LUSC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg06873352 chr17:61820015 STRADA 0.71 12.66 0.57 2.84e-30 Prudent dietary pattern; LUSC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg23093090 chr10:104574429 C10orf26 -0.45 -7.94 -0.4 3.09e-14 Arsenic metabolism; LUSC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg04756594 chr16:24857601 SLC5A11 -0.49 -6.88 -0.35 2.92e-11 Intelligence (multi-trait analysis); LUSC cis rs6574644 1.000 rs28501387 chr14:81772667 G/A cg01989461 chr14:81687754 GTF2A1 0.47 5.72 0.3 2.41e-8 Obesity-related traits; LUSC trans rs2236293 0.755 rs10758324 chr9:35799078 C/G cg11239633 chr3:37903682 CTDSPL -0.36 -6.51 -0.34 2.8e-10 Blood protein levels; LUSC cis rs4363385 0.818 rs678960 chr1:153011621 G/A cg00922841 chr1:152955080 SPRR1A -0.41 -7.21 -0.37 3.65e-12 Inflammatory skin disease; LUSC cis rs523522 0.962 rs7471 chr12:120941215 T/C cg27279351 chr12:120934652 DYNLL1 0.62 8.23 0.41 4.34e-15 High light scatter reticulocyte count; LUSC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.47 6.82 0.35 4.18e-11 Colonoscopy-negative controls vs population controls; LUSC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.67 10.55 0.5 1.21e-22 Body mass index (adult); LUSC cis rs3857536 0.544 rs208453 chr6:66906841 A/T cg07460842 chr6:66804631 NA -0.73 -9.77 -0.47 5.46e-20 Blood trace element (Cu levels); LUSC cis rs7098414 0.511 rs7899513 chr10:82150559 G/A cg01528321 chr10:82214614 TSPAN14 0.6 9.02 0.44 1.51e-17 Post bronchodilator FEV1; LUSC cis rs765787 0.530 rs11636018 chr15:45539137 T/C cg24006582 chr15:45444508 DUOX1 -0.6 -8.77 -0.43 9.28e-17 Uric acid levels; LUSC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg04352962 chr1:209979756 IRF6 0.55 6.3 0.33 9.18e-10 Cleft lip with or without cleft palate; LUSC cis rs9326248 0.581 rs7121898 chr11:116796846 A/T cg10130564 chr11:117069849 TAGLN 0.31 5.8 0.3 1.58e-8 Blood protein levels; LUSC cis rs4930561 0.765 rs7931502 chr11:67959607 A/C cg16338278 chr11:67432957 ALDH3B2 -0.39 -6.87 -0.35 3.14e-11 Breast cancer in childhood cancer survivors;IgG glycosylation; LUSC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg12963246 chr6:28129442 ZNF389 0.48 6.71 0.34 8.34e-11 Depression; LUSC cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg21535247 chr6:8435926 SLC35B3 0.58 8.95 0.44 2.49e-17 Motion sickness; LUSC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg20607798 chr8:58055168 NA 0.51 5.7 0.3 2.6e-8 Developmental language disorder (linguistic errors); LUSC cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg22535103 chr8:58192502 C8orf71 -0.79 -9.0 -0.44 1.69e-17 Developmental language disorder (linguistic errors); LUSC trans rs1864729 1.000 rs2853312 chr8:98281319 T/C cg08679828 chr8:102218111 ZNF706 -0.81 -7.39 -0.37 1.16e-12 Estradiol plasma levels (breast cancer); LUSC cis rs1371867 0.846 rs1788204 chr8:101303936 C/T cg06636551 chr8:101224915 SPAG1 -0.45 -8.26 -0.41 3.54e-15 Atrioventricular conduction; LUSC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg23283495 chr1:209979779 IRF6 -0.63 -7.71 -0.39 1.49e-13 Cleft lip with or without cleft palate; LUSC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg23490090 chr17:78081364 GAA 0.36 5.67 0.3 3.16e-8 Yeast infection; LUSC cis rs17253792 0.822 rs75115817 chr14:56069537 G/A cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs950169 0.610 rs34529571 chr15:84691807 A/G cg17173187 chr15:85201210 NMB 0.4 6.53 0.34 2.43e-10 Schizophrenia; LUSC cis rs934734 0.563 rs955903 chr2:65575553 A/G cg08085232 chr2:65598271 SPRED2 -0.43 -6.73 -0.35 7.36e-11 Rheumatoid arthritis; LUSC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg09877947 chr5:131593287 PDLIM4 0.45 7.08 0.36 8.79e-12 Breast cancer; LUSC cis rs4947962 0.585 rs17172440 chr7:55156010 G/T cg23757825 chr7:55092271 EGFR -0.46 -5.67 -0.3 3.08e-8 Subjective response to lithium treatment; LUSC cis rs13064411 0.696 rs6786974 chr3:113190149 T/A cg18753928 chr3:113234510 CCDC52 -0.51 -7.65 -0.39 2.1e-13 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs7264396 0.635 rs6060685 chr20:34512023 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.94 -0.44 2.7e-17 Total cholesterol levels; LUSC cis rs4919687 0.550 rs7907503 chr10:104440050 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -6.0 -0.31 5.27e-9 Colorectal cancer; LUSC cis rs4363385 0.510 rs11488175 chr1:153039778 A/G cg25856811 chr1:152973957 SPRR3 0.35 5.85 0.3 1.17e-8 Inflammatory skin disease; LUSC cis rs9815354 0.812 rs17283243 chr3:41914792 C/T cg03022575 chr3:42003672 ULK4 0.83 8.67 0.43 1.88e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg02466173 chr16:30829666 NA -0.6 -11.0 -0.52 3.27e-24 Multiple myeloma; LUSC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg18512352 chr11:47633146 NA 0.47 9.53 0.46 3.24e-19 Subjective well-being; LUSC cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg08048268 chr3:133502702 NA 0.35 6.37 0.33 6.28e-10 Alcohol consumption (transferrin glycosylation); LUSC cis rs6076065 0.676 rs6083084 chr20:23335582 A/G cg11657817 chr20:23433608 CST11 -0.46 -8.52 -0.42 5.39e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs6484504 0.817 rs67707190 chr11:31210500 A/G cg26647111 chr11:31128758 NA -0.45 -5.83 -0.3 1.3e-8 Red blood cell count; LUSC cis rs11792861 0.890 rs3750465 chr9:111900677 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 8.44 0.42 9.83e-16 Menarche (age at onset); LUSC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg20203395 chr5:56204925 C5orf35 -0.74 -10.17 -0.49 2.47e-21 Initial pursuit acceleration; LUSC cis rs11098499 0.779 rs28495013 chr4:120375831 A/C cg09307838 chr4:120376055 NA 0.78 11.26 0.52 3.82e-25 Corneal astigmatism; LUSC cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg01657329 chr11:68192670 LRP5 -0.44 -6.52 -0.34 2.57e-10 Total body bone mineral density; LUSC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg12463550 chr7:65579703 CRCP 0.52 7.58 0.38 3.51e-13 Aortic root size; LUSC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg00031303 chr3:195681400 NA 0.7 10.07 0.48 5.22e-21 Pancreatic cancer; LUSC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg14298792 chr15:30685198 CHRFAM7A -0.49 -6.05 -0.31 3.92e-9 Huntington's disease progression; LUSC trans rs1005277 0.579 rs2021649 chr10:38392122 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.46 -0.46 5.87e-19 Extrinsic epigenetic age acceleration; LUSC cis rs4319547 0.656 rs7397299 chr12:122821649 G/T cg23029597 chr12:123009494 RSRC2 -0.69 -9.04 -0.44 1.26e-17 Body mass index; LUSC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg22166914 chr1:53195759 ZYG11B 0.6 10.15 0.49 2.86e-21 Monocyte count; LUSC cis rs6964587 1.000 rs3753107 chr7:91629151 C/T cg17063962 chr7:91808500 NA -0.56 -9.06 -0.44 1.13e-17 Breast cancer; LUSC cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg16240275 chr20:61666158 NCRNA00029 0.42 9.24 0.45 2.9e-18 Prostate cancer (SNP x SNP interaction); LUSC trans rs11098499 0.954 rs6822679 chr4:120402702 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.47 6.45 0.33 4.01e-10 Corneal astigmatism; LUSC cis rs8028313 0.630 rs8035989 chr15:67965620 G/A cg24579218 chr15:68104479 NA -0.38 -6.55 -0.34 2.21e-10 Obesity; LUSC cis rs9814567 1.000 rs7648990 chr3:134244390 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -13.67 -0.6 4.42e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs7267979 0.903 rs6115118 chr20:25246734 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.78 16.08 0.66 1.78e-43 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.71 11.89 0.55 2.04e-27 Personality dimensions; LUSC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg07636037 chr3:49044803 WDR6 1.03 17.93 0.7 7.68e-51 Parkinson's disease; LUSC trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg17470723 chr8:74884337 TCEB1 0.53 8.24 0.41 4.02e-15 Prostate cancer (SNP x SNP interaction); LUSC trans rs17685 0.712 rs11764119 chr7:75812358 T/G cg19862616 chr7:65841803 NCRNA00174 1.08 17.87 0.7 1.37e-50 Coffee consumption;Coffee consumption (cups per day); LUSC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg04287289 chr16:89883240 FANCA 0.79 13.99 0.61 2.45e-35 Vitiligo; LUSC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg05340658 chr4:99064831 C4orf37 0.65 11.17 0.52 7.64e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7615316 0.934 rs2227930 chr3:142277575 A/T cg16271453 chr3:142027066 XRN1 -0.37 -6.39 -0.33 5.59e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9420 0.961 rs12807250 chr11:57600285 C/T cg02958346 chr11:57425731 CLP1 -0.44 -6.31 -0.33 8.67e-10 Schizophrenia; LUSC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg06713675 chr4:122721982 EXOSC9 -0.67 -11.83 -0.54 3.21e-27 Type 2 diabetes; LUSC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg04865166 chr7:105162814 PUS7 0.51 5.73 0.3 2.27e-8 Bipolar disorder (body mass index interaction); LUSC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg18240062 chr17:79603768 NPLOC4 0.7 12.82 0.57 7.47e-31 Eye color traits; LUSC cis rs295137 0.798 rs295142 chr2:201211716 C/T cg23649088 chr2:200775458 C2orf69 -0.39 -6.02 -0.31 4.72e-9 Asthma (bronchodilator response); LUSC cis rs73198271 0.515 rs76620708 chr8:8619083 C/T cg01851573 chr8:8652454 MFHAS1 0.63 7.22 0.37 3.47e-12 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs3125734 0.633 rs4979774 chr10:63967795 A/T cg09941381 chr10:64027924 RTKN2 -0.38 -7.14 -0.36 6.02e-12 Rheumatoid arthritis; LUSC cis rs59918340 0.764 rs10101692 chr8:142230823 C/T cg23750338 chr8:142222470 SLC45A4 0.58 11.26 0.52 3.76e-25 Immature fraction of reticulocytes; LUSC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg27165867 chr14:105738592 BRF1 -0.53 -7.76 -0.39 1.06e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11890956 chr21:40555474 PSMG1 1.03 20.38 0.74 1.47e-60 Cognitive function; LUSC cis rs722599 0.562 rs2287400 chr14:75182937 G/A cg08847533 chr14:75593920 NEK9 0.43 6.27 0.32 1.09e-9 IgG glycosylation; LUSC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg21918786 chr6:109611834 NA -0.41 -7.21 -0.37 3.87e-12 Reticulocyte fraction of red cells; LUSC cis rs7560272 0.723 rs1052161 chr2:73828538 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -7.18 -0.37 4.58e-12 Schizophrenia; LUSC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg08736216 chr1:53307985 ZYG11A -0.28 -5.83 -0.3 1.33e-8 Monocyte count; LUSC cis rs911119 1.000 rs13038305 chr20:23610262 C/T cg16589663 chr20:23618590 CST3 0.59 6.95 0.36 1.88e-11 Chronic kidney disease; LUSC cis rs3784262 1.000 rs4369598 chr15:58318603 G/T cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.98 -0.31 5.59e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); LUSC cis rs1568889 0.877 rs7933326 chr11:28288416 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 9.48 0.46 4.84e-19 Bipolar disorder; LUSC cis rs35995292 0.963 rs2392609 chr7:38952595 C/T cg19327137 chr7:38886074 VPS41 0.37 6.04 0.31 4.14e-9 Subjective well-being (multi-trait analysis); LUSC cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.72 0.43 1.33e-16 Menopause (age at onset); LUSC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg05802129 chr4:122689817 NA -0.5 -8.12 -0.41 9.17e-15 Type 2 diabetes; LUSC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08704250 chr15:31115839 NA -0.47 -6.94 -0.35 2.08e-11 Huntington's disease progression; LUSC trans rs9650657 0.504 rs10093053 chr8:11037187 T/C cg06636001 chr8:8085503 FLJ10661 -0.55 -8.19 -0.41 5.44e-15 Neuroticism; LUSC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg23758822 chr17:41437982 NA 1.04 19.44 0.73 7.67e-57 Menopause (age at onset); LUSC cis rs6582630 0.548 rs1607870 chr12:38385964 G/T cg26384229 chr12:38710491 ALG10B -0.56 -8.39 -0.42 1.4e-15 Drug-induced liver injury (flucloxacillin); LUSC trans rs9392918 0.967 rs9405351 chr6:7712582 A/G cg12631351 chr5:80256738 RASGRF2 0.37 6.35 0.33 7.11e-10 Height; LUSC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg13560548 chr3:10150139 C3orf24 0.47 6.6 0.34 1.58e-10 Alzheimer's disease; LUSC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg23248424 chr5:179741104 GFPT2 -0.48 -7.26 -0.37 2.8e-12 Height; LUSC cis rs7568458 1.000 rs7568458 chr2:85788175 T/A cg17127132 chr2:85788382 GGCX 0.47 7.45 0.38 8.14e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs4930103 0.874 rs80047492 chr11:2025032 A/T cg23202291 chr11:1979235 NA 0.39 6.04 0.31 4.01e-9 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs2279817 0.735 rs75044419 chr1:18008241 C/T cg21791023 chr1:18019539 ARHGEF10L -0.5 -6.13 -0.32 2.54e-9 Neuroticism; LUSC cis rs5769765 0.671 rs138833 chr22:50178917 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.67 -9.15 -0.45 5.86e-18 Schizophrenia; LUSC cis rs751728 0.664 rs9394167 chr6:33754396 A/G cg25922239 chr6:33757077 LEMD2 0.42 6.37 0.33 6.27e-10 Crohn's disease; LUSC cis rs4690686 0.554 rs13141274 chr4:177285027 C/T cg17059388 chr4:177262070 NA 0.31 6.2 0.32 1.67e-9 Essential tremor; LUSC cis rs2734839 0.964 rs2587548 chr11:113292212 G/C cg14159747 chr11:113255604 NA 0.23 5.78 0.3 1.69e-8 Information processing speed; LUSC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg05855489 chr10:104503620 C10orf26 -0.71 -11.55 -0.53 3.32e-26 Waist circumference;Hip circumference; LUSC cis rs1965732 1.000 rs11696000 chr2:3709907 A/G cg00999904 chr2:3704751 ALLC -0.33 -5.9 -0.31 8.91e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs11098499 0.657 rs4463052 chr4:120313258 T/C cg24375607 chr4:120327624 NA 0.77 11.43 0.53 9.27e-26 Corneal astigmatism; LUSC cis rs4660306 0.961 rs2991966 chr1:45999503 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -7.13 -0.36 6.36e-12 Homocysteine levels; LUSC trans rs2926702 0.810 rs726285 chr8:71071187 A/C cg16517358 chr11:46164796 NA -0.37 -5.98 -0.31 5.84e-9 Non-small cell lung cancer; LUSC cis rs500891 0.570 rs13208458 chr6:84093204 C/A cg08257003 chr6:84140564 ME1 0.32 7.29 0.37 2.29e-12 Platelet-derived growth factor BB levels; LUSC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg23711669 chr6:146136114 FBXO30 0.86 16.1 0.66 1.47e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg07636037 chr3:49044803 WDR6 1.07 18.35 0.71 1.71e-52 Parkinson's disease; LUSC cis rs977987 0.806 rs11643410 chr16:75428306 C/T cg03315344 chr16:75512273 CHST6 0.49 9.2 0.45 3.88e-18 Dupuytren's disease; LUSC cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg08045932 chr20:61659980 NA 0.58 10.25 0.49 1.33e-21 Prostate cancer (SNP x SNP interaction); LUSC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg02807482 chr3:125708958 NA -0.51 -6.33 -0.33 8.01e-10 Blood pressure (smoking interaction); LUSC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg02167203 chr6:41068553 NFYA;LOC221442 0.42 5.93 0.31 7.38e-9 Alzheimer's disease (late onset); LUSC cis rs12410462 0.581 rs4329477 chr1:227552494 A/G cg23173402 chr1:227635558 NA -0.53 -6.55 -0.34 2.21e-10 Major depressive disorder; LUSC trans rs10435719 0.899 rs11250177 chr8:11799099 G/A cg27411982 chr8:10470053 RP1L1 0.42 6.58 0.34 1.78e-10 C-reactive protein levels or triglyceride levels (pleiotropy); LUSC cis rs3736594 0.546 rs965813 chr2:27789861 T/A cg27432699 chr2:27873401 GPN1 0.66 8.89 0.44 4.02e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); LUSC cis rs3771570 0.901 rs55764424 chr2:242407467 C/T cg21155796 chr2:242212141 HDLBP 0.54 6.26 0.32 1.2e-9 Prostate cancer; LUSC cis rs1577917 0.727 rs9444361 chr6:86400900 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.54 8.55 0.42 4.46e-16 Response to antipsychotic treatment; LUSC cis rs12681288 0.578 rs56702775 chr8:968860 G/A cg15309053 chr8:964076 NA 0.42 8.42 0.42 1.11e-15 Schizophrenia; LUSC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg10802521 chr3:52805072 NEK4 -0.54 -8.63 -0.43 2.6e-16 Bipolar disorder; LUSC cis rs8092503 1.000 rs6566871 chr18:52475904 T/C cg12377874 chr18:52495404 RAB27B -0.32 -5.65 -0.3 3.43e-8 Childhood body mass index; LUSC cis rs12579753 0.957 rs35001833 chr12:82188510 C/G cg21231944 chr12:82153410 PPFIA2 -0.38 -5.88 -0.31 9.83e-9 Resting heart rate; LUSC cis rs2219968 0.961 rs2200014 chr8:78956394 A/T cg00738934 chr8:78996279 NA -0.33 -6.0 -0.31 5.1e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10088262 0.629 rs1367829 chr8:124797135 A/G cg20713898 chr8:124780851 FAM91A1 -0.55 -7.61 -0.38 2.87e-13 Pancreatic cancer; LUSC cis rs734999 0.967 rs6672381 chr1:2502834 A/G cg18854424 chr1:2615690 NA 0.47 9.77 0.47 5.59e-20 Ulcerative colitis; LUSC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg00310523 chr12:86230176 RASSF9 0.53 9.79 0.47 4.69e-20 Major depressive disorder; LUSC cis rs10843647 0.967 rs1948033 chr12:30329005 T/C cg12718339 chr12:29936407 TMTC1 -0.35 -5.87 -0.31 1.07e-8 Glucose homeostasis traits; LUSC cis rs10791323 0.598 rs10750550 chr11:133736083 A/G cg15485101 chr11:133734466 NA 0.39 7.28 0.37 2.35e-12 Childhood ear infection; LUSC cis rs4930103 0.935 rs2525881 chr11:2019333 T/C cg06197492 chr11:2016605 H19 0.42 6.94 0.35 2.08e-11 DNA methylation (parent-of-origin);DNA methylation (variation); LUSC cis rs2742417 1.000 rs938363 chr3:45746364 T/G cg09608765 chr3:45636137 LIMD1 -0.38 -7.51 -0.38 5.48e-13 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs2219968 0.700 rs10088166 chr8:78867175 T/C cg00738934 chr8:78996279 NA -0.36 -6.1 -0.32 3.01e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg21724239 chr8:58056113 NA 0.6 6.93 0.35 2.19e-11 Developmental language disorder (linguistic errors); LUSC cis rs7113850 0.541 rs74708033 chr11:24223512 C/T ch.11.24196551F chr11:24239977 NA 0.99 9.06 0.44 1.09e-17 Bone fracture in osteoporosis; LUSC cis rs7089973 0.604 rs12218498 chr10:116578489 T/C cg03647239 chr10:116582469 FAM160B1 0.45 7.13 0.36 6.13e-12 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7917772 0.510 rs2001389 chr10:104375258 G/A cg05855489 chr10:104503620 C10orf26 -0.48 -7.35 -0.37 1.53e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; LUSC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg02753203 chr1:228287806 NA 0.7 12.45 0.56 1.71e-29 Diastolic blood pressure; LUSC cis rs12824058 0.737 rs873663 chr12:130816316 C/T cg26677194 chr12:130822605 PIWIL1 0.59 8.45 0.42 8.85e-16 Menopause (age at onset); LUSC cis rs7312774 0.618 rs4964510 chr12:107357251 A/G cg16260113 chr12:107380972 MTERFD3 0.97 7.2 0.37 4.04e-12 Severe influenza A (H1N1) infection; LUSC cis rs116988415 0.584 rs1875054 chr14:65255066 G/A cg25083366 chr14:65239357 SPTB 0.65 6.69 0.34 9.18e-11 Daytime sleep phenotypes; LUSC cis rs9473147 0.516 rs9395283 chr6:47551444 T/C cg20196966 chr6:47445060 CD2AP 0.42 5.91 0.31 8.6e-9 Platelet distribution width;Mean platelet volume; LUSC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg11494091 chr17:61959527 GH2 0.38 6.56 0.34 2.1e-10 Height; LUSC cis rs2652834 0.861 rs4774472 chr15:63353760 C/A cg05507819 chr15:63340323 TPM1 0.71 9.19 0.45 4.19e-18 HDL cholesterol; LUSC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -7.36 -0.37 1.47e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs11711311 0.955 rs9881563 chr3:113414031 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.43 -6.04 -0.31 4.15e-9 IgG glycosylation; LUSC cis rs13064411 0.696 rs7622740 chr3:113206771 G/A cg18753928 chr3:113234510 CCDC52 -0.54 -8.23 -0.41 4.16e-15 Response to simvastatin treatment (PCSK9 protein level change); LUSC cis rs17597773 0.527 rs2484699 chr1:221083752 C/T cg16008148 chr1:221062819 NA 0.42 8.1 0.41 1.02e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg15997130 chr1:24165203 NA 0.5 8.23 0.41 4.21e-15 Immature fraction of reticulocytes; LUSC cis rs12701220 0.689 rs12536282 chr7:1115650 C/T cg00990874 chr7:1149470 C7orf50 -0.49 -5.75 -0.3 2.05e-8 Bronchopulmonary dysplasia; LUSC cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg23711669 chr6:146136114 FBXO30 0.88 16.1 0.66 1.48e-43 Lobe attachment (rater-scored or self-reported); LUSC cis rs62400317 0.893 rs62436782 chr6:45143118 T/A cg18551225 chr6:44695536 NA -0.42 -6.96 -0.36 1.84e-11 Total body bone mineral density; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg06527865 chr1:234746497 IRF2BP2 0.39 6.02 0.31 4.65e-9 Triglycerides; LUSC cis rs9815354 1.000 rs9824731 chr3:41889698 G/T cg03022575 chr3:42003672 ULK4 0.63 6.85 0.35 3.49e-11 Pulse pressure;Diastolic blood pressure; LUSC trans rs6773957 1.000 rs1063538 chr3:186574183 T/C cg01963189 chr4:121613795 NA -0.33 -6.07 -0.32 3.48e-9 Adiponectin levels; LUSC cis rs71386933 0.543 rs36114735 chr16:72017683 C/T cg08717414 chr16:71523259 ZNF19 -0.69 -5.87 -0.31 1.05e-8 Post bronchodilator FEV1; LUSC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg06671706 chr8:8559999 CLDN23 0.51 6.63 0.34 1.3100000000000001e-10 Obesity-related traits; LUSC cis rs9303401 0.659 rs16943326 chr17:57050365 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.87 13.36 0.59 6.67e-33 Cognitive test performance; LUSC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg07952391 chr2:88470173 THNSL2 0.76 6.71 0.34 8.32e-11 Plasma clusterin levels; LUSC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 16.21 0.66 5.15e-44 Platelet count; LUSC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg20203395 chr5:56204925 C5orf35 -0.74 -9.97 -0.48 1.14e-20 Initial pursuit acceleration; LUSC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg23093090 chr10:104574429 C10orf26 -0.37 -7.06 -0.36 9.95e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs1775715 0.677 rs2799034 chr10:32175896 A/G cg18675610 chr10:32216311 ARHGAP12 0.3 6.65 0.34 1.19e-10 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg05729581 chr11:3078854 CARS -0.53 -8.18 -0.41 5.98e-15 Longevity; LUSC cis rs4423214 0.879 rs1792283 chr11:71135136 T/C cg05163923 chr11:71159392 DHCR7 -0.66 -8.63 -0.43 2.56e-16 Vitamin D levels; LUSC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -19.2 -0.72 6.74e-56 Height; LUSC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg19622623 chr12:86230825 RASSF9 -0.43 -6.18 -0.32 1.86e-9 Major depressive disorder; LUSC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg16049864 chr8:95962084 TP53INP1 -0.46 -7.62 -0.38 2.67e-13 Type 2 diabetes; LUSC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg12564285 chr5:131593104 PDLIM4 0.35 6.3 0.33 9.49e-10 Blood metabolite levels; LUSC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg24881330 chr22:46731750 TRMU 0.87 7.07 0.36 8.96e-12 LDL cholesterol;Cholesterol, total; LUSC cis rs679087 0.606 rs167318 chr12:29943124 T/C cg14258853 chr12:29935411 TMTC1 -0.64 -7.81 -0.39 7.64e-14 Schizophrenia; LUSC cis rs7113850 0.541 rs74832028 chr11:24232359 A/T ch.11.24196551F chr11:24239977 NA 1.0 9.14 0.45 6e-18 Bone fracture in osteoporosis; LUSC cis rs17253792 0.822 rs76055105 chr14:56069127 A/G cg01858014 chr14:56050164 KTN1 -0.89 -7.33 -0.37 1.76e-12 Putamen volume; LUSC cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg00071950 chr4:10020882 SLC2A9 -0.51 -8.41 -0.42 1.23e-15 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs1014246 0.541 rs2011695 chr10:118507219 A/C cg14919929 chr10:118506882 NA -0.48 -7.97 -0.4 2.55e-14 Age at smoking initiation in chronic obstructive pulmonary disease; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg14702927 chr19:46366445 FOXA3;SYMPK -0.47 -5.99 -0.31 5.42e-9 Bipolar disorder and schizophrenia; LUSC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg13126279 chr21:47581558 C21orf56 0.47 7.05 0.36 1e-11 Testicular germ cell tumor; LUSC cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg07606381 chr6:8435919 SLC35B3 0.72 12.12 0.55 2.79e-28 Motion sickness; LUSC cis rs2455601 1.000 rs2455601 chr11:8899400 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.46 -6.95 -0.36 1.98e-11 Schizophrenia; LUSC trans rs45509595 0.556 rs34409918 chr6:27685348 A/G cg06606381 chr12:133084897 FBRSL1 -0.94 -8.61 -0.43 2.86e-16 Breast cancer; LUSC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg23093090 chr10:104574429 C10orf26 -0.37 -6.94 -0.35 2.06e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs9309473 0.607 rs6720094 chr2:73588076 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -7.47 -0.38 7.23e-13 Metabolite levels; LUSC cis rs4237845 0.537 rs7969844 chr12:58278271 C/T cg00677455 chr12:58241039 CTDSP2 0.71 11.07 0.52 1.83e-24 Intelligence (multi-trait analysis); LUSC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg02487422 chr3:49467188 NICN1 0.45 7.08 0.36 8.66e-12 Resting heart rate; LUSC cis rs1557765 0.527 rs4756887 chr11:17394597 T/G cg15432903 chr11:17409602 KCNJ11 0.43 7.6 0.38 2.96e-13 Body mass index;Social communication problems; LUSC trans rs4014195 0.521 rs12576996 chr11:65580638 G/T cg17712092 chr4:129076599 LARP1B 0.57 6.82 0.35 4.24e-11 Glomerular filtration rate (creatinine);Chronic kidney disease; LUSC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg11764359 chr7:65958608 NA -0.53 -7.03 -0.36 1.18e-11 Aortic root size; LUSC cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg13010199 chr12:38710504 ALG10B 0.67 10.23 0.49 1.56e-21 Bladder cancer; LUSC cis rs6964587 0.904 rs6465339 chr7:91570790 T/A cg17063962 chr7:91808500 NA -0.56 -9.0 -0.44 1.74e-17 Breast cancer; LUSC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg05347473 chr6:146136440 FBXO30 -0.58 -9.74 -0.47 6.76e-20 Lobe attachment (rater-scored or self-reported); LUSC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg21963583 chr11:68658836 MRPL21 0.56 8.33 0.41 2.15e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs1448094 0.842 rs12318815 chr12:86452281 T/C cg00310523 chr12:86230176 RASSF9 -0.35 -6.35 -0.33 6.92e-10 Major depressive disorder; LUSC cis rs1403694 0.515 rs1624569 chr3:186450069 A/G cg12454167 chr3:186435060 KNG1 0.28 7.38 0.37 1.25e-12 Blood protein levels; LUSC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg24881330 chr22:46731750 TRMU 0.88 8.84 0.44 5.52e-17 LDL cholesterol;Cholesterol, total; LUSC cis rs1552244 0.507 rs6443274 chr3:9995288 A/T cg00149659 chr3:10157352 C3orf10 0.62 8.93 0.44 2.82e-17 Alzheimer's disease; LUSC cis rs11871801 0.517 rs665268 chr17:40722029 A/G cg16308533 chr17:40838983 CNTNAP1 0.4 5.88 0.31 1e-8 Crohn's disease; LUSC cis rs79349575 0.749 rs2546491 chr17:46977916 A/G cg22482690 chr17:47019901 SNF8 0.4 7.53 0.38 4.81e-13 Type 2 diabetes; LUSC cis rs77633900 0.614 rs1443110 chr15:76928322 C/T cg21673338 chr15:77095150 SCAPER 0.74 7.41 0.38 1.06e-12 Non-glioblastoma glioma;Glioma; LUSC cis rs10751667 0.560 rs10902265 chr11:1003642 G/A ch.11.42038R chr11:967971 AP2A2 0.47 6.99 0.36 1.49e-11 Alzheimer's disease (late onset); LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg00679716 chr14:23067188 ABHD4 -0.45 -6.09 -0.32 3.05e-9 Hepatitis; LUSC cis rs2290416 0.892 rs76108894 chr8:144673533 G/A cg14809332 chr8:144654887 C8orf73 0.54 6.53 0.34 2.41e-10 Attention deficit hyperactivity disorder; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg00929878 chr9:95087334 NOL8;CENPP 0.46 7.5 0.38 5.68e-13 Triglycerides; LUSC cis rs4242434 0.927 rs11781149 chr8:22473158 C/T cg03733263 chr8:22462867 KIAA1967 0.99 17.86 0.7 1.52e-50 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); LUSC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg00484396 chr16:3507460 NAT15 0.69 12.06 0.55 4.78e-28 Tuberculosis; LUSC cis rs2197308 0.740 rs1842595 chr12:37906223 G/A cg26384229 chr12:38710491 ALG10B -0.82 -13.55 -0.6 1.28e-33 Morning vs. evening chronotype; LUSC cis rs3812762 0.879 rs10743088 chr11:8787620 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.38 6.62 0.34 1.42e-10 Hypospadias; LUSC cis rs77216612 0.877 rs66561220 chr12:12878765 T/C cg04607235 chr12:12878440 APOLD1 -0.96 -15.77 -0.65 2.85e-42 Lymphocyte counts; LUSC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg26441486 chr22:50317300 CRELD2 0.48 7.17 0.37 4.93e-12 Schizophrenia; LUSC trans rs877282 0.583 rs12358255 chr10:828626 C/T cg22713356 chr15:30763199 NA 0.78 9.99 0.48 9.81e-21 Uric acid levels; LUSC cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg09997546 chr11:8931473 C11orf17;ST5 -0.35 -7.49 -0.38 6.15e-13 Hemoglobin concentration; LUSC trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg15704280 chr7:45808275 SEPT13 -0.57 -7.07 -0.36 8.93e-12 Acute lymphoblastic leukemia (childhood); LUSC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg20503657 chr10:835505 NA 0.87 11.66 0.54 1.4e-26 Eosinophil percentage of granulocytes; LUSC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg11366901 chr6:160182831 ACAT2 0.92 13.16 0.58 3.76e-32 Age-related macular degeneration (geographic atrophy); LUSC cis rs7264396 0.887 rs4911510 chr20:34093153 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.39 -0.33 5.72e-10 Total cholesterol levels; LUSC cis rs73206853 0.764 rs3026468 chr12:110758081 T/A cg12870014 chr12:110450643 ANKRD13A 0.68 6.44 0.33 4.21e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg24642439 chr20:33292090 TP53INP2 0.53 8.16 0.41 6.81e-15 Coronary artery disease; LUSC cis rs2354432 0.607 rs7545467 chr1:146746248 A/G cg25205988 chr1:146714368 CHD1L -0.99 -9.33 -0.45 1.49e-18 Mitochondrial DNA levels; LUSC cis rs4946717 0.716 rs4478446 chr6:106472120 T/A cg02270332 chr6:106475062 NA 0.46 9.45 0.46 6.05e-19 Inflammatory bowel disease; LUSC cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg01483505 chr11:975446 AP2A2 0.42 5.9 0.31 9.15e-9 Alzheimer's disease (late onset); LUSC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg18099408 chr3:52552593 STAB1 -0.41 -7.03 -0.36 1.2e-11 Bipolar disorder; LUSC cis rs9400467 0.528 rs4276544 chr6:111759699 A/G cg22127309 chr6:111907043 TRAF3IP2 -0.36 -6.73 -0.35 7.4e-11 Blood metabolite levels;Amino acid levels; LUSC cis rs1044826 0.623 rs4383548 chr3:139040515 C/T cg00490450 chr3:139108681 COPB2 0.53 6.6 0.34 1.6e-10 Obesity-related traits; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg02567981 chr12:50101354 FMNL3 0.5 7.37 0.37 1.36e-12 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs7939886 0.764 rs79601668 chr11:55753767 G/C cg03929089 chr4:120376271 NA 0.79 6.5 0.34 2.94e-10 Myopia (pathological); LUSC cis rs113835537 0.559 rs11227498 chr11:66269714 A/G cg24851651 chr11:66362959 CCS 0.54 8.06 0.4 1.38e-14 Airway imaging phenotypes; LUSC cis rs11577318 0.537 rs12030833 chr1:26689220 A/G cg00852783 chr1:26633632 UBXN11 -0.53 -7.33 -0.37 1.78e-12 Granulocyte percentage of myeloid white cells; LUSC cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg07148914 chr20:33460835 GGT7 0.53 8.16 0.41 7.08e-15 Height; LUSC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg05340658 chr4:99064831 C4orf37 0.66 11.29 0.53 2.88e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs4253772 0.938 rs41371446 chr22:46637272 T/C cg18190219 chr22:46762943 CELSR1 -0.51 -5.92 -0.31 7.92e-9 LDL cholesterol;Cholesterol, total; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg08181751 chr6:24646551 KIAA0319 0.45 6.05 0.31 3.98e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs1559088 0.948 rs6510346 chr19:33598526 T/A cg27124370 chr19:33622961 WDR88 0.57 7.46 0.38 7.64e-13 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs854765 0.547 rs7224047 chr17:17932931 G/A cg04398451 chr17:18023971 MYO15A -0.54 -9.06 -0.44 1.13e-17 Total body bone mineral density; LUSC cis rs11039100 1.000 rs11039110 chr11:5829111 A/G cg05234568 chr11:5960015 NA -0.5 -5.7 -0.3 2.64e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs6964587 1.000 rs4727266 chr7:91570129 C/T cg22709100 chr7:91322751 NA -0.38 -5.72 -0.3 2.37e-8 Breast cancer; LUSC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg06001716 chr17:41278141 BRCA1;NBR2 0.41 6.55 0.34 2.2e-10 Menopause (age at onset); LUSC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg09491104 chr22:46646882 C22orf40 -0.64 -7.45 -0.38 8e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs9287719 0.837 rs4331474 chr2:10755583 G/A cg03983476 chr2:10830698 NOL10 -0.38 -5.76 -0.3 1.88e-8 Prostate cancer; LUSC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg22834771 chr12:69754056 YEATS4 -0.49 -7.37 -0.37 1.31e-12 Blood protein levels; LUSC cis rs2073300 1.000 rs34449811 chr20:23443771 T/C cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs2439831 0.867 rs2412779 chr15:43655927 A/G cg02155558 chr15:43621948 ADAL;LCMT2 1.07 13.25 0.59 1.75e-32 Lung cancer in ever smokers; LUSC cis rs6582630 0.599 rs1851114 chr12:38424671 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.19 -0.41 5.5e-15 Drug-induced liver injury (flucloxacillin); LUSC cis rs2011503 0.941 rs76944848 chr19:19417512 C/T cg22782873 chr19:19639568 YJEFN3 -0.53 -6.17 -0.32 1.95e-9 Bipolar disorder; LUSC cis rs11098499 0.909 rs11723757 chr4:120299669 C/T cg09307838 chr4:120376055 NA 0.77 11.04 0.52 2.25e-24 Corneal astigmatism; LUSC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg11494091 chr17:61959527 GH2 0.64 13.79 0.6 1.46e-34 Prudent dietary pattern; LUSC cis rs951366 0.649 rs7522056 chr1:205735891 A/G cg24503407 chr1:205819492 PM20D1 0.48 6.91 0.35 2.5e-11 Menarche (age at onset); LUSC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg13390004 chr1:15929781 NA 0.42 7.0 0.36 1.43e-11 Systolic blood pressure; LUSC cis rs10464366 0.843 rs1525798 chr7:39112580 A/C cg18850127 chr7:39170497 POU6F2 0.41 5.98 0.31 5.62e-9 IgG glycosylation; LUSC cis rs68170813 0.559 rs11761181 chr7:106954879 T/C cg24556660 chr7:106842632 COG5;HBP1 -0.43 -5.83 -0.3 1.29e-8 Coronary artery disease; LUSC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg09491104 chr22:46646882 C22orf40 -0.72 -7.44 -0.38 8.4e-13 LDL cholesterol;Cholesterol, total; LUSC cis rs2652834 1.000 rs2729783 chr15:63403316 C/T cg05507819 chr15:63340323 TPM1 0.54 6.38 0.33 5.82e-10 HDL cholesterol; LUSC cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg15544633 chr2:99771531 LIPT1;TSGA10 -0.93 -12.24 -0.56 1.05e-28 Chronic sinus infection; LUSC cis rs4629710 0.563 rs9483238 chr6:131567196 A/T cg12700074 chr6:131571435 AKAP7 -0.35 -5.85 -0.31 1.15e-8 Multiple myeloma (IgH translocation); LUSC cis rs1030877 1.000 rs2576737 chr2:105891510 C/T cg02079111 chr2:105885981 TGFBRAP1 0.78 14.95 0.63 4.61e-39 Obesity-related traits; LUSC cis rs736408 0.677 rs678 chr3:52820981 A/T cg11645453 chr3:52864694 ITIH4 0.36 7.92 0.4 3.64e-14 Bipolar disorder; LUSC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg08355456 chr11:67383691 NA -0.32 -5.91 -0.31 8.51e-9 Mean corpuscular volume; LUSC cis rs929354 0.713 rs3802129 chr7:156965297 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC cis rs75920871 0.528 rs7108912 chr11:116925996 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.5 -6.42 -0.33 4.69e-10 Subjective well-being; LUSC trans rs9341835 0.511 rs1744146 chr6:64221869 A/C cg19533977 chr17:57719682 CLTC 0.33 6.07 0.32 3.53e-9 Schizophrenia; LUSC cis rs870825 0.616 rs6834156 chr4:185639903 G/C cg04058563 chr4:185651563 MLF1IP 0.88 13.86 0.6 7.72e-35 Blood protein levels; LUSC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg11062466 chr8:58055876 NA 0.57 7.22 0.37 3.61e-12 Developmental language disorder (linguistic errors); LUSC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg03676636 chr4:99064102 C4orf37 0.35 7.85 0.39 5.8e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg03609598 chr5:56110824 MAP3K1 -0.39 -5.88 -0.31 1.01e-8 Initial pursuit acceleration; LUSC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.29 -7.38 -0.37 1.27e-12 Lymphocyte counts; LUSC cis rs713477 1.000 rs12887846 chr14:55911139 T/C cg13175173 chr14:55914753 NA -0.32 -6.74 -0.35 7.01e-11 Pediatric bone mineral content (femoral neck); LUSC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.96 20.8 0.75 3.31e-62 Prudent dietary pattern; LUSC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg21643547 chr1:205240462 TMCC2 -0.5 -9.45 -0.46 6e-19 Mean corpuscular volume;Mean platelet volume; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg20600053 chr18:56806937 SEC11C 0.41 6.04 0.31 4.14e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -7.4 -0.38 1.13e-12 Developmental language disorder (linguistic errors); LUSC cis rs11098499 0.865 rs11722183 chr4:120280597 A/C cg09307838 chr4:120376055 NA 0.76 11.3 0.53 2.82e-25 Corneal astigmatism; LUSC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg08280861 chr8:58055591 NA 0.55 6.49 0.33 3.02e-10 Developmental language disorder (linguistic errors); LUSC cis rs7980687 0.527 rs28533432 chr12:123873242 C/T cg13010344 chr12:123464640 ARL6IP4 -0.5 -7.55 -0.38 4.09e-13 Height;Educational attainment;Head circumference (infant); LUSC cis rs9462027 0.628 rs9462019 chr6:34748730 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.1e-8 Systemic lupus erythematosus; LUSC cis rs6696846 0.729 rs72757512 chr1:205079203 G/A cg00857998 chr1:205179979 DSTYK 0.64 10.09 0.48 4.63e-21 Red blood cell count; LUSC cis rs4595586 0.545 rs12811619 chr12:39392196 T/C cg26384229 chr12:38710491 ALG10B 0.49 7.03 0.36 1.14e-11 Morning vs. evening chronotype; LUSC cis rs7599312 0.532 rs7564590 chr2:213387900 C/T cg16329650 chr2:213403929 ERBB4 0.48 7.1 0.36 7.54e-12 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs11098499 0.826 rs12511640 chr4:120251248 T/C cg24375607 chr4:120327624 NA 0.76 12.17 0.55 1.85e-28 Corneal astigmatism; LUSC cis rs34375054 0.525 rs7136220 chr12:125602684 T/C cg25124228 chr12:125621409 AACS -0.58 -9.55 -0.46 2.95e-19 Post bronchodilator FEV1/FVC ratio; LUSC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs13242816 1.000 rs62471202 chr7:116112562 G/A cg16553024 chr7:116138462 CAV2 -0.52 -5.71 -0.3 2.44e-8 P wave duration; LUSC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg00343986 chr7:65444356 GUSB -0.42 -6.46 -0.33 3.76e-10 Aortic root size; LUSC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg08219700 chr8:58056026 NA 0.65 7.17 0.37 4.83e-12 Developmental language disorder (linguistic errors); LUSC cis rs72781680 0.898 rs72782106 chr2:24022009 A/G cg20701182 chr2:24300061 SF3B14 0.73 7.39 0.37 1.2e-12 Lymphocyte counts; LUSC cis rs868036 0.609 rs16951304 chr15:68089618 T/C cg24579218 chr15:68104479 NA -0.41 -6.49 -0.33 3.09e-10 Restless legs syndrome; LUSC cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -9.26 -0.45 2.59e-18 Cleft plate (environmental tobacco smoke interaction); LUSC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg22823121 chr1:150693482 HORMAD1 -0.51 -7.56 -0.38 3.98e-13 Melanoma; LUSC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC cis rs9395066 0.545 rs4711805 chr6:44870102 T/C cg25276700 chr6:44698697 NA 0.3 5.96 0.31 6.26e-9 Height; LUSC cis rs2762353 0.935 rs1165195 chr6:25815080 T/G cg03264133 chr6:25882463 NA -0.44 -7.61 -0.38 2.76e-13 Blood metabolite levels; LUSC cis rs6964587 1.000 rs6969536 chr7:91689351 C/G cg22709100 chr7:91322751 NA 0.39 5.73 0.3 2.27e-8 Breast cancer; LUSC cis rs259282 0.538 rs8100917 chr19:33114702 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.68 10.0 0.48 8.82e-21 Schizophrenia; LUSC trans rs4605213 0.528 rs12951858 chr17:49328627 C/G cg26211529 chr7:79554138 NA 0.32 6.06 0.31 3.58e-9 Height; LUSC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg06134567 chr22:46658398 PKDREJ -0.46 -5.65 -0.3 3.44e-8 LDL cholesterol;Cholesterol, total; LUSC cis rs11122272 0.735 rs10489611 chr1:231517854 A/T cg06096015 chr1:231504339 EGLN1 0.56 10.0 0.48 9.18e-21 Hemoglobin concentration; LUSC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg02221750 chr19:17393354 ANKLE1 0.9 14.42 0.62 5.31e-37 Systemic lupus erythematosus; LUSC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg25204440 chr1:209979598 IRF6 0.51 6.73 0.35 7.43e-11 Cleft lip with or without cleft palate; LUSC cis rs9837602 1.000 rs7616988 chr3:99701134 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.5 -6.22 -0.32 1.47e-9 Breast cancer; LUSC cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.53 -8.04 -0.4 1.62e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs4700695 0.719 rs27077 chr5:65445342 C/T cg21114390 chr5:65439923 SFRS12 0.62 9.31 0.45 1.78e-18 Facial morphology (factor 19); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg01867433 chr22:38966164 DMC1 -0.39 -6.11 -0.32 2.71e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs3806843 1.000 rs1548701 chr5:140164557 T/C cg19875535 chr5:140030758 IK 0.5 8.24 0.41 3.98e-15 Depressive symptoms (multi-trait analysis); LUSC trans rs62103177 0.564 rs3930042 chr18:77723843 G/A cg14227996 chr4:17616232 MED28 0.64 6.85 0.35 3.62e-11 Opioid sensitivity; LUSC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg03676636 chr4:99064102 C4orf37 0.36 7.85 0.39 5.64e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs1178968 0.591 rs10440929 chr7:72786770 A/C cg25889504 chr7:72793014 NA 0.61 7.85 0.39 5.62e-14 Triglyceride levels; LUSC cis rs8038465 0.615 rs11637315 chr15:73944068 G/C cg15420318 chr15:73925796 NPTN 0.6 10.26 0.49 1.16e-21 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs68170813 0.641 rs12538848 chr7:106984569 G/T cg02696742 chr7:106810147 HBP1 -0.6 -9.08 -0.45 9.51e-18 Coronary artery disease; LUSC trans rs11250098 0.574 rs4554431 chr8:10771638 T/A cg06636001 chr8:8085503 FLJ10661 -0.53 -7.41 -0.38 1.04e-12 Morning vs. evening chronotype; LUSC cis rs9326248 0.581 rs7106437 chr11:116992076 T/C cg20608306 chr11:116969690 SIK3 0.36 6.7 0.34 9.04e-11 Blood protein levels; LUSC cis rs28374715 0.635 rs28557159 chr15:41657353 T/C cg18705301 chr15:41695430 NDUFAF1 -0.95 -20.29 -0.74 3.18e-60 Ulcerative colitis; LUSC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg22963979 chr7:1858916 MAD1L1 -0.62 -9.86 -0.47 2.63e-20 Bipolar disorder and schizophrenia; LUSC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg20307385 chr11:47447363 PSMC3 0.45 5.9 0.31 8.99e-9 Subjective well-being; LUSC cis rs7771547 0.519 rs6928287 chr6:36375438 G/A cg07856975 chr6:36356162 ETV7 0.44 6.54 0.34 2.34e-10 Platelet distribution width; LUSC cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg11764359 chr7:65958608 NA -0.68 -10.88 -0.51 8.08e-24 Aortic root size; LUSC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg26408565 chr15:76604113 ETFA -0.48 -7.63 -0.39 2.46e-13 Blood metabolite levels; LUSC cis rs7512552 0.582 rs834233 chr1:150354276 G/A cg15654264 chr1:150340011 RPRD2 0.6 9.39 0.46 9.44e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); LUSC cis rs11239930 0.934 rs10900313 chr1:146560747 T/A cg02487331 chr1:146550467 NA -0.31 -5.71 -0.3 2.47e-8 AIDS progression; LUSC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg22166914 chr1:53195759 ZYG11B -0.59 -9.78 -0.47 4.95e-20 Monocyte count; LUSC cis rs698813 0.573 rs6544750 chr2:44490780 T/C cg00619915 chr2:44497795 NA -0.55 -7.7 -0.39 1.56e-13 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); LUSC cis rs2617583 0.967 rs2617594 chr5:1448288 A/G cg07148919 chr5:1466943 LPCAT1 0.42 6.29 0.33 1.02e-9 Breast cancer; LUSC cis rs9815354 0.812 rs17215589 chr3:41831203 C/T cg03022575 chr3:42003672 ULK4 0.86 8.63 0.43 2.54e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs2262909 0.962 rs55735642 chr19:22241176 C/T cg11619707 chr19:22235551 ZNF257 0.39 5.83 0.3 1.29e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; LUSC cis rs4691139 0.903 rs10434177 chr4:165915531 A/T cg25904183 chr4:165877875 C4orf39;TRIM61 -0.45 -6.04 -0.31 4.04e-9 Ovarian cancer in BRCA1 mutation carriers; LUSC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg24675658 chr1:53192096 ZYG11B 0.72 12.03 0.55 6.08e-28 Monocyte count; LUSC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg25251562 chr2:3704773 ALLC -0.49 -7.44 -0.38 8.43e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); LUSC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg23161317 chr6:28129485 ZNF389 -0.42 -5.66 -0.3 3.21e-8 Depression; LUSC cis rs80282103 0.867 rs12241632 chr10:1069070 A/T cg18964960 chr10:1102726 WDR37 0.65 6.38 0.33 5.96e-10 Glomerular filtration rate (creatinine); LUSC cis rs7719624 0.870 rs1990199 chr5:135395543 G/C cg12897067 chr5:135418308 NA 0.42 6.05 0.31 3.94e-9 Response to cytidine analogues (gemcitabine); LUSC cis rs796364 0.806 rs76112266 chr2:201087157 C/G cg23649088 chr2:200775458 C2orf69 -0.54 -6.35 -0.33 7.07e-10 Schizophrenia; LUSC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg19912559 chr1:40204330 PPIE 0.51 7.8 0.39 7.84e-14 Blood protein levels; LUSC cis rs2742417 0.603 rs2742457 chr3:45767487 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.22 -0.37 3.57e-12 Response to anti-depressant treatment in major depressive disorder; LUSC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg01448562 chr3:133502909 NA -0.65 -10.61 -0.5 7.25e-23 Iron status biomarkers; LUSC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg06873352 chr17:61820015 STRADA -0.71 -12.59 -0.57 5.02e-30 Prudent dietary pattern; LUSC cis rs2235649 0.798 rs9932983 chr16:1848184 A/G cg19030554 chr16:1822289 NME3;MRPS34;EME2 -0.45 -6.06 -0.31 3.72e-9 Blood metabolite levels; LUSC cis rs10464366 0.560 rs12672089 chr7:39132816 G/A cg21665744 chr7:39171113 POU6F2 0.4 6.31 0.33 8.91e-10 IgG glycosylation; LUSC trans rs8072100 0.967 rs4239163 chr17:45755954 C/T cg04995722 chr7:26192034 NFE2L3 -0.36 -5.97 -0.31 6.03e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7809950 1.000 rs2712215 chr7:107188207 A/G cg23024343 chr7:107201750 COG5 -0.57 -8.96 -0.44 2.29e-17 Coronary artery disease; LUSC cis rs12893668 0.703 rs55751606 chr14:104028806 G/A cg04998671 chr14:104000505 TRMT61A -0.47 -6.68 -0.34 9.96e-11 Reticulocyte count; LUSC cis rs1577917 1.000 rs11759855 chr6:86610841 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.48 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; LUSC cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg20503657 chr10:835505 NA 0.63 7.93 0.4 3.38e-14 Eosinophil percentage of granulocytes; LUSC cis rs1403694 0.695 rs11924390 chr3:186433099 T/C cg12454167 chr3:186435060 KNG1 0.34 8.42 0.42 1.1e-15 Blood protein levels; LUSC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg07092213 chr7:1199455 ZFAND2A -0.41 -6.34 -0.33 7.63e-10 Longevity;Endometriosis; LUSC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg10729496 chr3:10149963 C3orf24 0.54 7.15 0.36 5.48e-12 Alzheimer's disease; LUSC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg25019033 chr10:957182 NA -0.51 -6.26 -0.32 1.19e-9 Eosinophil percentage of granulocytes; LUSC cis rs1443512 0.812 rs1975470 chr12:54336841 G/A cg25024717 chr12:54324583 NA -0.38 -6.42 -0.33 4.58e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); LUSC cis rs73206853 0.841 rs56065235 chr12:111016287 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 6.51 0.34 2.76e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); LUSC cis rs12458462 0.892 rs12456692 chr18:77482189 C/T cg11879182 chr18:77439856 CTDP1 0.73 11.81 0.54 3.76e-27 Monocyte count; LUSC cis rs2204008 0.805 rs7296063 chr12:37964775 T/G cg26384229 chr12:38710491 ALG10B 0.93 15.88 0.66 1.04e-42 Bladder cancer; LUSC cis rs16867321 0.950 rs4667223 chr2:181498302 C/G cg23363182 chr2:181467187 NA -0.44 -5.7 -0.3 2.69e-8 Obesity; LUSC cis rs6087990 0.842 rs4911105 chr20:31330413 G/A cg13636640 chr20:31349939 DNMT3B 0.98 21.42 0.76 1.15e-64 Ulcerative colitis; LUSC cis rs10504229 0.817 rs55949560 chr8:58167603 T/C cg11062466 chr8:58055876 NA 0.43 5.77 0.3 1.81e-8 Developmental language disorder (linguistic errors); LUSC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg05855489 chr10:104503620 C10orf26 -0.68 -10.09 -0.48 4.41e-21 Allergic disease (asthma, hay fever or eczema); LUSC cis rs6429082 0.585 rs7524848 chr1:235711688 G/C cg26050004 chr1:235667680 B3GALNT2 -0.45 -5.92 -0.31 8e-9 Adiposity; LUSC cis rs2235649 0.828 rs9936486 chr16:1849888 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.44 -6.18 -0.32 1.84e-9 Blood metabolite levels; LUSC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg24578937 chr1:2090814 PRKCZ -0.45 -10.12 -0.48 3.61e-21 Height; LUSC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.19 0.45 4.24e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs500891 0.859 rs62419327 chr6:84154298 C/T cg08257003 chr6:84140564 ME1 0.35 7.26 0.37 2.71e-12 Platelet-derived growth factor BB levels; LUSC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg06108461 chr20:60628389 TAF4 -0.96 -17.13 -0.68 1.22e-47 Body mass index; LUSC cis rs9902453 0.542 rs3809789 chr17:27955761 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.52 0.38 5.06e-13 Coffee consumption (cups per day); LUSC cis rs4889855 0.505 rs12952775 chr17:78607820 A/G cg16591659 chr17:78472290 NA -0.33 -5.82 -0.3 1.37e-8 Fractional excretion of uric acid; LUSC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg27572855 chr1:25598939 RHD 0.42 7.36 0.37 1.4e-12 Erythrocyte sedimentation rate; LUSC cis rs11122272 0.701 rs11122273 chr1:231476789 A/G cg06096015 chr1:231504339 EGLN1 0.46 8.12 0.41 9.39e-15 Hemoglobin concentration; LUSC cis rs17102423 0.558 rs11628664 chr14:65615651 C/T cg11161011 chr14:65562177 MAX -0.63 -8.44 -0.42 1e-15 Obesity-related traits; LUSC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg03579872 chr1:53393473 SCP2 -0.39 -5.87 -0.31 1.05e-8 Monocyte count; LUSC cis rs2180341 0.597 rs11154397 chr6:127646649 G/C cg27446573 chr6:127587934 RNF146 0.62 9.97 0.48 1.19e-20 Breast cancer; LUSC cis rs2289583 0.544 rs6495132 chr15:75255322 C/T cg10253484 chr15:75165896 SCAMP2 0.46 6.39 0.33 5.49e-10 Systemic lupus erythematosus; LUSC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg17385448 chr1:15911702 AGMAT 0.36 6.18 0.32 1.82e-9 Systolic blood pressure; LUSC cis rs950169 0.519 rs7237 chr15:85186577 C/T cg17507749 chr15:85114479 UBE2QP1 0.56 7.08 0.36 8.46e-12 Schizophrenia; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11965880 chr10:23003653 PIP4K2A -0.41 -5.96 -0.31 6.33e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6460942 0.505 rs73290446 chr7:12358133 T/G cg06484146 chr7:12443880 VWDE -0.58 -6.11 -0.32 2.85e-9 Coronary artery disease; LUSC cis rs2952156 0.916 rs903506 chr17:37879762 G/A cg20243544 chr17:37824526 PNMT 0.49 6.97 0.36 1.7e-11 Asthma; LUSC cis rs829883 0.872 rs1641641 chr12:98896018 A/C cg25150519 chr12:98850993 NA 0.63 9.43 0.46 7.25e-19 Colorectal adenoma (advanced); LUSC cis rs17034641 0.938 rs12990701 chr2:46372472 C/G cg12428440 chr2:46370979 PRKCE 0.44 6.09 0.32 3.03e-9 Hemoglobin;Hematocrit; LUSC cis rs7927592 0.956 rs2510384 chr11:68391837 C/A cg20283391 chr11:68216788 NA -0.59 -8.29 -0.41 2.76e-15 Total body bone mineral density; LUSC cis rs9788721 0.836 rs17483686 chr15:78733390 A/T cg18825076 chr15:78729989 IREB2 -0.59 -9.76 -0.47 5.72e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04219446 chr17:73629082 RECQL5;LOC643008 0.41 6.58 0.34 1.79e-10 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg05340658 chr4:99064831 C4orf37 0.66 11.03 0.52 2.58e-24 Colonoscopy-negative controls vs population controls; LUSC cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg00857998 chr1:205179979 DSTYK 0.56 8.45 0.42 9.41e-16 Mean corpuscular volume;Mean platelet volume; LUSC cis rs506338 0.517 rs471618 chr11:64465403 T/C cg19395706 chr11:64412079 NRXN2 0.28 5.73 0.3 2.18e-8 Body mass index;Urate levels; LUSC cis rs2445762 0.642 rs72729210 chr15:51633629 G/A cg07517944 chr15:51633816 GLDN 0.41 6.78 0.35 5.32e-11 Hormone measurements; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T ch.8.34907260F chr8:34787718 NA -0.45 -6.14 -0.32 2.33e-9 Hepatitis; LUSC cis rs9616064 0.506 rs2542038 chr22:47059282 C/T cg05621596 chr22:47072043 GRAMD4 -0.4 -6.72 -0.35 7.78e-11 Urate levels in obese individuals; LUSC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg25554036 chr4:6271136 WFS1 -0.6 -11.4 -0.53 1.15e-25 Type 2 diabetes and other traits;Type 2 diabetes; LUSC cis rs1371867 0.839 rs1788186 chr8:101335686 T/C cg06002616 chr8:101225028 SPAG1 -0.41 -6.82 -0.35 4.37e-11 Atrioventricular conduction; LUSC cis rs28647808 0.881 rs28622217 chr9:136267323 A/G cg14268506 chr9:136215580 SNORD36B;MED22;SNORD24;RPL7A -0.6 -5.97 -0.31 6.15e-9 Blood protein levels; LUSC cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg25258033 chr6:167368657 RNASET2 0.47 7.88 0.4 4.71e-14 Crohn's disease; LUSC cis rs7945705 0.846 rs4929911 chr11:8816495 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.56 10.93 0.51 5.54e-24 Hemoglobin concentration; LUSC cis rs7945705 0.791 rs12421789 chr11:8813956 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.32 -6.35 -0.33 7.21e-10 Hemoglobin concentration; LUSC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg13206674 chr6:150067644 NUP43 0.58 9.08 0.45 9.37e-18 Lung cancer; LUSC cis rs7572644 0.664 rs4313931 chr2:28074701 C/T cg27432699 chr2:27873401 GPN1 0.52 6.62 0.34 1.45e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 12.43 0.56 2.07e-29 Prudent dietary pattern; LUSC cis rs7771547 0.542 rs597153 chr6:36395997 C/T cg07856975 chr6:36356162 ETV7 0.34 6.21 0.32 1.61e-9 Platelet distribution width; LUSC trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg15704280 chr7:45808275 SEPT13 -0.95 -13.81 -0.6 1.24e-34 Coronary artery disease; LUSC cis rs7215564 0.908 rs756077 chr17:78663071 A/G cg23238734 chr17:78661607 RPTOR 0.48 6.07 0.32 3.39e-9 Myopia (pathological); LUSC trans rs11992162 0.636 rs13265816 chr8:11797485 G/A cg15556689 chr8:8085844 FLJ10661 0.48 6.81 0.35 4.53e-11 Monocyte count; LUSC cis rs7561273 0.609 rs1056122 chr2:24342505 C/T cg06627628 chr2:24431161 ITSN2 0.51 6.99 0.36 1.5e-11 Quantitative traits; LUSC cis rs9309473 0.528 rs2091022 chr2:73564570 G/A cg20560298 chr2:73613845 ALMS1 -0.56 -8.2 -0.41 5.09e-15 Metabolite levels; LUSC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg01802117 chr1:53393560 SCP2 -0.39 -6.44 -0.33 4.23e-10 Monocyte count; LUSC cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg09184832 chr6:79620586 NA -0.44 -7.18 -0.37 4.46e-12 Intelligence (multi-trait analysis); LUSC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg22535103 chr8:58192502 C8orf71 -0.58 -6.91 -0.35 2.45e-11 Developmental language disorder (linguistic errors); LUSC cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg25208724 chr1:156163844 SLC25A44 1.04 17.84 0.7 1.71e-50 Testicular germ cell tumor; LUSC cis rs7072216 0.763 rs733345 chr10:100164215 G/T cg26618903 chr10:100175079 PYROXD2 -0.47 -8.89 -0.44 3.82e-17 Metabolite levels; LUSC cis rs2153535 0.935 rs11243254 chr6:8381242 C/T cg07606381 chr6:8435919 SLC35B3 -0.52 -7.77 -0.39 9.97e-14 Motion sickness; LUSC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.62 -12.99 -0.58 1.64e-31 Hemoglobin concentration; LUSC cis rs4460629 0.521 rs12039316 chr1:155073221 C/T cg23973274 chr1:155060172 NA -0.32 -6.27 -0.32 1.13e-9 Serum magnesium levels; LUSC cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg06627557 chr7:32535165 LSM5;AVL9 0.97 16.54 0.67 2.5e-45 Cognitive ability; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09687332 chr3:49977370 RBM6 0.46 6.15 0.32 2.27e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs9815354 1.000 rs9823254 chr3:41894768 G/C cg03022575 chr3:42003672 ULK4 0.63 6.9 0.35 2.57e-11 Pulse pressure;Diastolic blood pressure; LUSC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg14159672 chr1:205819179 PM20D1 0.79 13.28 0.59 1.3e-32 Menarche (age at onset); LUSC trans rs72674100 1.000 rs17026330 chr4:97969873 G/A cg09670535 chr1:18959427 PAX7 -0.56 -5.97 -0.31 6.09e-9 Post bronchodilator FEV1/FVC ratio; LUSC cis rs2147959 0.824 rs10916313 chr1:228625882 C/G cg18477163 chr1:228402036 OBSCN -0.43 -6.04 -0.31 4.16e-9 Adult asthma; LUSC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg06221963 chr1:154839813 KCNN3 -0.64 -14.82 -0.63 1.54e-38 Prostate cancer; LUSC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.12 0.41 9.02e-15 Prudent dietary pattern; LUSC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg13770153 chr20:60521292 NA -0.63 -8.55 -0.42 4.57e-16 Body mass index; LUSC cis rs2073300 0.609 rs6137914 chr20:23358364 C/T cg12062639 chr20:23401060 NAPB 0.98 7.88 0.4 4.66e-14 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs77741769 0.571 rs12371178 chr12:121309129 T/C cg02419362 chr12:121203948 SPPL3 0.46 8.56 0.42 4.08e-16 Mean corpuscular volume; LUSC trans rs61931739 0.517 rs7958856 chr12:34294737 T/C cg26384229 chr12:38710491 ALG10B 0.72 11.71 0.54 9.17e-27 Morning vs. evening chronotype; LUSC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg15596816 chr17:45501030 LOC100272146;C17orf57 -0.41 -6.47 -0.33 3.53e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs7119 0.931 rs11630540 chr15:77833625 G/A cg27398640 chr15:77910606 LINGO1 -0.32 -7.16 -0.36 5.07e-12 Type 2 diabetes; LUSC cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.05e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs765787 0.530 rs11636410 chr15:45535913 A/C cg24006582 chr15:45444508 DUOX1 0.59 8.3 0.41 2.6e-15 Uric acid levels; LUSC cis rs12594515 1.000 rs7162201 chr15:45992658 A/C cg01629716 chr15:45996671 NA 0.39 5.89 0.31 9.44e-9 Waist circumference;Weight; LUSC cis rs34779708 0.931 rs2384283 chr10:35326789 G/A cg03585969 chr10:35415529 CREM 0.63 9.08 0.44 9.93e-18 Inflammatory bowel disease;Crohn's disease; LUSC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs4953076 0.573 rs2054005 chr2:44401843 C/T cg04920474 chr2:44395004 PPM1B 0.67 8.63 0.43 2.62e-16 Height; LUSC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg01181863 chr3:195395398 SDHAP2 -0.59 -8.04 -0.4 1.53e-14 Pancreatic cancer; LUSC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg01802117 chr1:53393560 SCP2 -0.43 -7.19 -0.37 4.19e-12 Monocyte count; LUSC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg26314531 chr2:26401878 FAM59B 0.73 10.21 0.49 1.79e-21 Gut microbiome composition (summer); LUSC cis rs950027 0.620 rs1719246 chr15:45625479 T/A cg21132104 chr15:45694354 SPATA5L1 0.41 6.02 0.31 4.69e-9 Response to fenofibrate (adiponectin levels); LUSC cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg24812749 chr6:127587940 RNF146 0.92 14.01 0.61 2.1e-35 Breast cancer; LUSC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg00129232 chr17:37814104 STARD3 -0.52 -8.06 -0.4 1.38e-14 Asthma; LUSC cis rs4253772 0.530 rs9615933 chr22:46677298 G/A cg24881330 chr22:46731750 TRMU 0.8 6.72 0.35 7.8e-11 LDL cholesterol;Cholesterol, total; LUSC cis rs62458065 0.513 rs787216 chr7:32578891 G/A cg06627557 chr7:32535165 LSM5;AVL9 -0.55 -5.98 -0.31 5.87e-9 Metabolite levels (HVA/MHPG ratio); LUSC cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg19628046 chr18:33552617 C18orf21 0.5 6.03 0.31 4.41e-9 Endometriosis;Drug-induced torsades de pointes; LUSC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.96 0.48 1.26e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.42 6.04 0.31 4.11e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs859767 0.501 rs6742638 chr2:135407360 T/G cg12500956 chr2:135428796 TMEM163 -0.27 -6.29 -0.33 9.76e-10 Neuroticism; LUSC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg21724239 chr8:58056113 NA 0.57 6.61 0.34 1.56e-10 Developmental language disorder (linguistic errors); LUSC cis rs208520 0.690 rs4710311 chr6:66823223 C/T cg07460842 chr6:66804631 NA -1.02 -16.11 -0.66 1.34e-43 Exhaled nitric oxide output; LUSC cis rs4919087 0.962 rs10882889 chr10:99045890 A/G cg25902810 chr10:99078978 FRAT1 0.47 6.61 0.34 1.56e-10 Monocyte count; LUSC cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg23711669 chr6:146136114 FBXO30 0.76 13.58 0.6 9.51e-34 Lobe attachment (rater-scored or self-reported); LUSC cis rs1580019 0.883 rs6945294 chr7:32472099 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.84 12.74 0.57 1.41e-30 Cognitive ability; LUSC cis rs28595532 0.546 rs36058627 chr4:119233201 G/T cg21605333 chr4:119757512 SEC24D 0.73 6.2 0.32 1.67e-9 Cannabis dependence symptom count; LUSC trans rs12599106 0.679 rs34584967 chr16:34475725 T/G cg01171360 chr6:293285 DUSP22 -0.51 -7.62 -0.38 2.57e-13 Menopause (age at onset); LUSC cis rs34779708 0.931 rs4934721 chr10:35377715 A/G cg04310649 chr10:35416472 CREM -0.43 -6.38 -0.33 5.76e-10 Inflammatory bowel disease;Crohn's disease; LUSC cis rs208520 0.955 rs208532 chr6:66961280 T/A cg07460842 chr6:66804631 NA -0.96 -12.45 -0.56 1.77e-29 Exhaled nitric oxide output; LUSC cis rs708547 0.957 rs1623306 chr4:57773595 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.52 6.28 0.33 1.04e-9 Response to bleomycin (chromatid breaks); LUSC cis rs9650315 0.586 rs56042981 chr8:57207813 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.64 7.8 0.39 7.83e-14 Height; LUSC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg00945038 chr17:61921165 SMARCD2 0.53 9.23 0.45 3.27e-18 Prudent dietary pattern; LUSC cis rs1949733 0.701 rs4696828 chr4:8455604 G/A cg11789530 chr4:8429930 ACOX3 -0.59 -9.08 -0.44 9.65e-18 Response to antineoplastic agents; LUSC cis rs12618769 0.597 rs3769713 chr2:99151434 A/G cg10123293 chr2:99228465 UNC50 0.5 8.12 0.41 9.36e-15 Bipolar disorder; LUSC cis rs67366981 0.925 rs66846709 chr14:77692812 G/A cg22824376 chr14:77648248 TMEM63C 0.75 6.95 0.36 1.89e-11 Obsessive-compulsive symptoms; LUSC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg02079420 chr8:82753780 SNX16 0.41 7.01 0.36 1.29e-11 Diastolic blood pressure; LUSC cis rs17401966 0.838 rs61775887 chr1:10284733 T/C cg19773385 chr1:10388646 KIF1B -0.51 -8.44 -0.42 1.01e-15 Hepatocellular carcinoma; LUSC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.85 13.49 0.59 2.03e-33 Allergic disease (asthma, hay fever or eczema); LUSC cis rs7824557 0.527 rs2572369 chr8:11238597 C/T cg21775007 chr8:11205619 TDH -0.63 -9.91 -0.48 1.84e-20 Retinal vascular caliber; LUSC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.86 -0.81 6.04e-78 Height; LUSC trans rs7944735 0.507 rs10742827 chr11:48102350 C/T cg15704280 chr7:45808275 SEPT13 0.58 7.29 0.37 2.3e-12 Intraocular pressure; LUSC cis rs4423214 0.879 rs1790324 chr11:71150520 A/C cg05163923 chr11:71159392 DHCR7 -0.66 -9.07 -0.44 1.06e-17 Vitamin D levels; LUSC cis rs9467773 0.620 rs2498351 chr6:26659642 C/T cg05738196 chr6:26577821 NA 0.79 14.91 0.63 6.82e-39 Intelligence (multi-trait analysis); LUSC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg07636037 chr3:49044803 WDR6 1.03 17.81 0.7 2.29e-50 Parkinson's disease; LUSC cis rs6599077 1.000 rs113909479 chr3:40097967 C/G cg13683864 chr3:40499215 RPL14 -0.61 -7.25 -0.37 2.94e-12 Sleep-related phenotypes; LUSC cis rs12545109 0.800 rs2670026 chr8:57424338 G/T cg09654669 chr8:57350985 NA -0.55 -7.77 -0.39 9.95e-14 Obesity-related traits; LUSC cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg13256891 chr4:100009986 ADH5 0.5 6.92 0.35 2.31e-11 Smoking initiation; LUSC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg06484146 chr7:12443880 VWDE -0.7 -6.98 -0.36 1.62e-11 Coronary artery disease; LUSC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg22166914 chr1:53195759 ZYG11B 0.68 11.57 0.53 2.95e-26 Monocyte count; LUSC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03576123 chr11:487126 PTDSS2 0.96 10.56 0.5 1.08e-22 Body mass index; LUSC cis rs62064224 0.702 rs2302277 chr17:30791509 C/G cg24550644 chr17:30846204 MYO1D -0.38 -6.14 -0.32 2.38e-9 Schizophrenia; LUSC cis rs4499344 0.730 rs410616 chr19:33106109 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.84 12.93 0.58 2.86e-31 Mean platelet volume; LUSC cis rs2274273 0.870 rs10139083 chr14:55782735 C/A cg04306507 chr14:55594613 LGALS3 0.54 11.84 0.54 2.97e-27 Protein biomarker; LUSC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg21770322 chr7:97807741 LMTK2 0.41 7.06 0.36 9.5e-12 Prostate cancer (SNP x SNP interaction); LUSC cis rs62408225 0.963 rs62408211 chr6:90902808 A/T cg06866423 chr6:90926672 BACH2 0.38 5.7 0.3 2.7e-8 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg14993813 chr1:46806288 NSUN4 -0.51 -7.21 -0.37 3.84e-12 Menopause (age at onset); LUSC cis rs11264799 0.716 rs1113662 chr1:157635825 T/C cg18268488 chr1:157545234 FCRL4 0.33 5.75 0.3 2.02e-8 IgA nephropathy; LUSC cis rs7677751 0.806 rs4864859 chr4:55090015 A/G cg17187183 chr4:55093834 PDGFRA 0.38 5.83 0.3 1.3e-8 Corneal astigmatism; LUSC cis rs12618769 0.625 rs72819970 chr2:99034554 C/G cg10123293 chr2:99228465 UNC50 0.46 7.75 0.39 1.09e-13 Bipolar disorder; LUSC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg05313129 chr8:58192883 C8orf71 -0.5 -5.78 -0.3 1.69e-8 Developmental language disorder (linguistic errors); LUSC cis rs6840360 0.571 rs62327275 chr4:152548238 G/T cg22705602 chr4:152727874 NA -0.32 -6.41 -0.33 4.85e-10 Intelligence (multi-trait analysis); LUSC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03517284 chr6:25882590 NA 0.46 7.88 0.4 4.78e-14 Intelligence (multi-trait analysis); LUSC cis rs1775715 0.966 rs1755066 chr10:32309160 C/G cg04359828 chr10:32216031 ARHGAP12 -0.35 -5.84 -0.3 1.21e-8 Bipolar disorder with mood-incongruent psychosis; LUSC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg27494647 chr7:150038898 RARRES2 0.52 7.89 0.4 4.43e-14 Blood protein levels;Circulating chemerin levels; LUSC cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg21643547 chr1:205240462 TMCC2 -0.53 -10.19 -0.49 2.1e-21 Mean corpuscular volume;Mean platelet volume; LUSC cis rs4499344 0.730 rs7246338 chr19:33099504 T/C cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.83 12.73 0.57 1.49e-30 Mean platelet volume; LUSC cis rs6570726 0.934 rs9484995 chr6:145781114 T/A cg05347473 chr6:146136440 FBXO30 -0.38 -6.23 -0.32 1.38e-9 Lobe attachment (rater-scored or self-reported); LUSC cis rs9395066 0.525 rs1971482 chr6:44991113 C/T cg25276700 chr6:44698697 NA 0.29 6.01 0.31 4.91e-9 Height; LUSC cis rs11971779 0.680 rs17613690 chr7:139088401 C/T cg07862535 chr7:139043722 LUC7L2 -0.57 -7.17 -0.37 4.9e-12 Diisocyanate-induced asthma; LUSC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg17848003 chr1:3704513 LRRC47 0.33 6.25 0.32 1.24e-9 Red cell distribution width; LUSC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg19812747 chr11:111475976 SIK2 -0.55 -8.18 -0.41 5.88e-15 Primary sclerosing cholangitis; LUSC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.73 7.61 0.38 2.91e-13 Initial pursuit acceleration; LUSC cis rs12586317 0.620 rs58320987 chr14:35587726 T/C cg05294307 chr14:35346193 BAZ1A -0.57 -7.1 -0.36 7.76e-12 Psoriasis; LUSC trans rs8002861 0.967 rs7983109 chr13:44484351 C/A cg17145862 chr1:211918768 LPGAT1 0.23 6.1 0.32 2.97e-9 Leprosy; LUSC cis rs6681460 0.932 rs524114 chr1:67188335 C/T cg02459107 chr1:67143332 SGIP1 -0.44 -7.89 -0.4 4.37e-14 Presence of antiphospholipid antibodies; LUSC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg13319975 chr6:146136371 FBXO30 -0.5 -7.41 -0.38 1.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg05585544 chr11:47624801 NA -0.4 -6.89 -0.35 2.75e-11 Subjective well-being; LUSC cis rs78579285 0.589 rs113010486 chr16:88798398 A/G cg01900006 chr16:88814613 FAM38A 0.6 6.66 0.34 1.13e-10 Joint mobility (Beighton score); LUSC cis rs1008375 0.933 rs4698637 chr4:17632843 A/T cg18681998 chr4:17616180 MED28 0.88 16.23 0.66 4.22e-44 Parasitemia in Tripanosoma cruzi seropositivity; LUSC trans rs62064224 0.702 rs735555 chr17:30817450 A/G cg05065690 chr12:49246007 DDX23 0.4 6.37 0.33 6.3e-10 Schizophrenia; LUSC cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 5.82 0.3 1.36e-8 Schizophrenia; LUSC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg00814883 chr7:100076585 TSC22D4 -0.67 -9.02 -0.44 1.51e-17 Platelet count; LUSC trans rs57046232 0.552 rs6038449 chr20:6337980 C/T cg21095983 chr6:86352623 SYNCRIP 0.47 7.04 0.36 1.11e-11 Colorectal cancer; LUSC cis rs28595532 0.920 rs17258830 chr4:119725543 A/T cg14228332 chr4:119757509 SEC24D -0.8 -6.12 -0.32 2.64e-9 Cannabis dependence symptom count; LUSC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg03433033 chr1:76189801 ACADM 0.79 12.3 0.56 6.25e-29 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg22166914 chr1:53195759 ZYG11B 0.54 8.61 0.43 2.83e-16 Monocyte count; LUSC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg04944784 chr2:26401820 FAM59B -0.76 -11.18 -0.52 7.33e-25 Gut microbiome composition (summer); LUSC cis rs7681440 0.605 rs1372509 chr4:90817311 A/G cg15133208 chr4:90757351 SNCA -0.33 -5.69 -0.3 2.75e-8 Dementia with Lewy bodies; LUSC cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.78 -0.3 1.71e-8 Lobe attachment (rater-scored or self-reported); LUSC cis rs3791556 0.898 rs3828222 chr2:240109568 A/G cg03281426 chr2:240109471 HDAC4 -0.54 -7.72 -0.39 1.34e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg22549504 chr19:17448937 GTPBP3 0.55 7.2 0.37 4.1e-12 Systemic lupus erythematosus; LUSC cis rs7954584 0.626 rs12809676 chr12:122442381 C/A cg22618164 chr12:122356400 WDR66 0.59 8.47 0.42 7.74e-16 Mean corpuscular volume; LUSC cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg06784218 chr1:46089804 CCDC17 0.54 11.04 0.52 2.29e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC trans rs4942242 1.000 rs1105856 chr13:44227067 G/T cg19169023 chr15:41853346 TYRO3 0.47 7.58 0.38 3.34e-13 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg25358565 chr5:93447407 FAM172A 1.07 14.1 0.61 9.68e-36 Diabetic retinopathy; LUSC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg09365446 chr1:150670422 GOLPH3L 0.47 7.01 0.36 1.33e-11 Tonsillectomy; LUSC cis rs10504229 0.863 rs75954631 chr8:58166194 C/A cg22535103 chr8:58192502 C8orf71 -0.77 -7.86 -0.4 5.29e-14 Developmental language disorder (linguistic errors); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg06564803 chr16:70100193 PDXDC2 -0.39 -5.97 -0.31 5.96e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs6964587 1.000 rs35317449 chr7:91637010 G/A cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.08e-8 Breast cancer; LUSC cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.51 5.76 0.3 1.93e-8 Schizophrenia; LUSC cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg26384229 chr12:38710491 ALG10B 0.86 14.0 0.61 2.4e-35 Bladder cancer; LUSC cis rs508618 0.666 rs480902 chr1:231531627 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.53 6.96 0.36 1.75e-11 Red blood cell count; LUSC cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg19875535 chr5:140030758 IK -0.53 -8.69 -0.43 1.61e-16 Depressive symptoms (multi-trait analysis); LUSC trans rs7824557 0.767 rs28507159 chr8:11166076 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.63 0.34 1.34e-10 Retinal vascular caliber; LUSC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg18131467 chr2:239335373 ASB1 1.04 25.83 0.82 1.25e-81 Multiple system atrophy; LUSC cis rs3820928 0.934 rs60141402 chr2:227761445 A/C cg11843606 chr2:227700838 RHBDD1 -0.53 -7.74 -0.39 1.21e-13 Pulmonary function; LUSC cis rs7267979 1.000 rs6050559 chr20:25329915 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.87 20.03 0.74 3.52e-59 Liver enzyme levels (alkaline phosphatase); LUSC cis rs1878931 0.501 rs9635547 chr16:3416664 C/T cg22508957 chr16:3507546 NAT15 -0.41 -6.47 -0.33 3.49e-10 Body mass index (adult); LUSC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg15242686 chr22:24348715 GSTTP1 0.48 7.66 0.39 2.02e-13 Liver enzyme levels (gamma-glutamyl transferase); LUSC trans rs12554020 0.582 rs2001609 chr9:96395363 C/T cg03862290 chr14:101515739 MIR655 0.48 6.08 0.32 3.32e-9 Schizophrenia; LUSC cis rs3617 0.503 rs9866243 chr3:52915219 C/T cg18404041 chr3:52824283 ITIH1 0.41 7.12 0.36 6.57e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs1065852 0.526 rs2413663 chr22:42402399 T/A cg22189786 chr22:42395067 WBP2NL 0.43 5.75 0.3 2.06e-8 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); LUSC cis rs7315438 0.600 rs12367485 chr12:115885910 G/A cg24172291 chr12:115889509 NA -0.36 -6.15 -0.32 2.18e-9 Colorectal cancer; LUSC cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg05347473 chr6:146136440 FBXO30 0.56 9.54 0.46 3.02e-19 Lobe attachment (rater-scored or self-reported); LUSC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg25036284 chr2:26402008 FAM59B 0.66 8.7 0.43 1.55e-16 Gut microbiome composition (summer); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00023492 chr1:19970710 NBL1 -0.49 -6.04 -0.31 4.1e-9 Bipolar disorder and schizophrenia; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg24752028 chr2:30369779 YPEL5 -0.51 -6.12 -0.32 2.61e-9 Bipolar disorder and schizophrenia; LUSC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg24879335 chr3:133465180 TF 0.45 7.82 0.39 7.1e-14 Iron status biomarkers (transferrin levels); LUSC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg01416388 chr22:39784598 NA -0.43 -6.93 -0.35 2.21e-11 Intelligence (multi-trait analysis); LUSC cis rs9925964 0.869 rs2288004 chr16:31054040 G/C cg02466173 chr16:30829666 NA 0.35 6.44 0.33 4.18e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs8060686 0.641 rs8060893 chr16:68191608 A/T cg09835421 chr16:68378352 PRMT7 -0.54 -5.92 -0.31 7.97e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs4911259 0.552 rs6057663 chr20:31463071 G/T cg13636640 chr20:31349939 DNMT3B -0.82 -15.9 -0.66 8.57e-43 Inflammatory bowel disease; LUSC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg06637938 chr14:75390232 RPS6KL1 0.5 7.69 0.39 1.61e-13 Height; LUSC cis rs7267979 0.966 rs2257712 chr20:25264910 T/C cg08601574 chr20:25228251 PYGB 0.45 6.81 0.35 4.56e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs2011503 0.941 rs17751061 chr19:19413092 C/T cg15839431 chr19:19639596 YJEFN3 -0.51 -5.87 -0.31 1.04e-8 Bipolar disorder; LUSC cis rs7291412 1.000 rs7291412 chr22:46459132 G/T cg23691090 chr22:46449981 C22orf26;LOC150381 0.43 6.94 0.35 2.06e-11 Dupuytren's disease;Subjective well-being; LUSC cis rs11190604 0.767 rs872290 chr10:102198879 G/A cg07080220 chr10:102295463 HIF1AN 0.62 8.27 0.41 3.32e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs6762 0.692 rs7928925 chr11:839155 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.54 -7.33 -0.37 1.76e-12 Mean platelet volume; LUSC cis rs7940866 0.774 rs10466547 chr11:130823576 T/C cg12179176 chr11:130786555 SNX19 0.61 9.17 0.45 4.96e-18 Schizophrenia; LUSC cis rs936229 0.813 rs2301249 chr15:75092384 T/C cg10253484 chr15:75165896 SCAMP2 -0.53 -7.16 -0.36 5.24e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.69 8.83 0.44 5.91e-17 Schizophrenia; LUSC cis rs2463822 1.000 rs1406384 chr11:62083530 A/G cg06239285 chr11:62104954 ASRGL1 -0.98 -11.14 -0.52 9.91e-25 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs202629 1 rs202629 chr22:41849975 C/T cg03806693 chr22:41940476 POLR3H 0.93 13.79 0.6 1.44e-34 Cannabis dependence symptom count; LUSC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg12463550 chr7:65579703 CRCP 0.45 6.17 0.32 1.99e-9 Aortic root size; LUSC trans rs6445525 1.000 rs6805139 chr3:66005660 G/A cg12639933 chr12:57626296 SHMT2 0.34 6.1 0.32 3e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg05717871 chr11:638507 DRD4 -0.37 -6.39 -0.33 5.7e-10 Systemic lupus erythematosus; LUSC cis rs9837602 1.000 rs4075038 chr3:99680086 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 5.77 0.3 1.84e-8 Breast cancer; LUSC cis rs61931739 0.534 rs2625897 chr12:34064295 G/A cg06521331 chr12:34319734 NA -0.51 -8.43 -0.42 1.09e-15 Morning vs. evening chronotype; LUSC cis rs9467773 0.967 rs1056347 chr6:26527524 G/C cg11502198 chr6:26597334 ABT1 0.59 9.3 0.45 1.84e-18 Intelligence (multi-trait analysis); LUSC cis rs7267979 1.000 rs6037105 chr20:25374199 C/A cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs12042107 0.656 rs1342780 chr1:91198676 A/C cg13456504 chr1:91191583 NA 0.39 6.38 0.33 5.8e-10 Educational attainment; LUSC cis rs4285028 0.948 rs35902163 chr3:121649526 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.71 -0.47 8.51e-20 Multiple sclerosis; LUSC cis rs1451375 0.794 rs11238133 chr7:50542914 A/C cg18232548 chr7:50535776 DDC -0.61 -9.43 -0.46 6.97e-19 Malaria; LUSC cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg21252483 chr19:49399788 TULP2 -0.48 -6.76 -0.35 6.21e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; LUSC cis rs4713675 0.584 rs9380375 chr6:33682391 G/A cg14003231 chr6:33640908 ITPR3 0.29 5.75 0.3 2.02e-8 Plateletcrit; LUSC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 11.39 0.53 1.32e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs8060686 0.516 rs7194894 chr16:68145062 C/T cg05110241 chr16:68378359 PRMT7 -0.51 -6.12 -0.32 2.69e-9 HDL cholesterol;Metabolic syndrome; LUSC cis rs34779708 0.931 rs72789609 chr10:35306206 C/T cg04310649 chr10:35416472 CREM -0.4 -6.07 -0.32 3.51e-9 Inflammatory bowel disease;Crohn's disease; LUSC cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg13010199 chr12:38710504 ALG10B 0.67 10.31 0.49 8.3e-22 Bladder cancer; LUSC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg06742321 chr12:123595122 PITPNM2 0.38 5.79 0.3 1.59e-8 Platelet count; LUSC cis rs9457247 0.602 rs13204839 chr6:167471119 G/A cg25258033 chr6:167368657 RNASET2 0.45 6.81 0.35 4.5e-11 Crohn's disease; LUSC cis rs11711311 0.955 rs12634241 chr3:113397685 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -5.98 -0.31 5.72e-9 IgG glycosylation; LUSC cis rs936229 0.813 rs2168519 chr15:75080872 T/C cg10253484 chr15:75165896 SCAMP2 -0.49 -6.45 -0.33 4.04e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); LUSC cis rs2404602 0.655 rs8028294 chr15:77084877 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.09 0.36 7.86e-12 Blood metabolite levels; LUSC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg06112835 chr11:68658793 MRPL21 0.5 7.65 0.39 2.23e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg08508325 chr11:3079039 CARS -0.5 -11.89 -0.55 2.01e-27 Longevity; LUSC trans rs7819412 0.502 rs4841499 chr8:10988138 A/C cg06636001 chr8:8085503 FLJ10661 -0.48 -6.36 -0.33 6.45e-10 Triglycerides; LUSC cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg02380750 chr20:61661411 NA 0.34 6.01 0.31 4.97e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs11112613 0.818 rs73184099 chr12:106018143 A/G cg03607813 chr12:105948248 NA 0.73 9.06 0.44 1.14e-17 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; LUSC cis rs977987 0.736 rs11865296 chr16:75473693 C/T cg03315344 chr16:75512273 CHST6 0.48 9.4 0.46 8.91e-19 Dupuytren's disease; LUSC trans rs12571093 0.656 rs3858147 chr10:70013264 A/G cg04882175 chr6:131122610 NA -0.52 -5.97 -0.31 6.17e-9 Optic nerve measurement (disc area); LUSC cis rs62400317 0.859 rs28583363 chr6:45231336 T/A cg18551225 chr6:44695536 NA -0.44 -7.28 -0.37 2.46e-12 Total body bone mineral density; LUSC cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg03676636 chr4:99064102 C4orf37 0.36 7.94 0.4 3.15e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs3782089 0.793 rs34789990 chr11:65252477 G/T cg21890820 chr11:65308645 LTBP3 1.39 9.51 0.46 3.82e-19 Height; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg03395546 chr19:41222599 ADCK4;ITPKC -0.56 -6.88 -0.35 3.05e-11 Bipolar disorder and schizophrenia; LUSC cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg22676075 chr6:135203613 NA 0.58 9.08 0.44 9.79e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; LUSC cis rs8072100 1.000 rs11650372 chr17:45721795 G/A cg25173405 chr17:45401733 C17orf57 -0.4 -6.49 -0.33 3.06e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg16606324 chr3:10149918 C3orf24 0.64 9.55 0.46 2.89e-19 Alzheimer's disease; LUSC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg03351412 chr1:154909251 PMVK 0.42 6.42 0.33 4.69e-10 Prostate cancer; LUSC cis rs73198271 0.740 rs10092600 chr8:8649023 A/G cg01851573 chr8:8652454 MFHAS1 0.55 9.14 0.45 6.38e-18 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs9650657 0.504 rs10109167 chr8:11033525 C/T cg21775007 chr8:11205619 TDH -0.54 -7.87 -0.4 5.07e-14 Neuroticism; LUSC cis rs877282 0.945 rs11599043 chr10:777972 C/T cg17470449 chr10:769945 NA 0.52 7.42 0.38 9.92e-13 Uric acid levels; LUSC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg08219700 chr8:58056026 NA 0.5 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); LUSC trans rs17236969 0.557 rs72887143 chr2:156597056 A/T cg04365699 chr3:177320997 NA -0.26 -5.97 -0.31 5.97e-9 Menarche (age at onset); LUSC cis rs1371867 0.846 rs1660330 chr8:101305015 T/A cg00191853 chr8:101177733 SPAG1 -0.41 -6.56 -0.34 2.08e-10 Atrioventricular conduction; LUSC cis rs3741151 1.000 rs74795285 chr11:73033387 A/G cg17517138 chr11:73019481 ARHGEF17 1.14 9.76 0.47 5.59e-20 GIP levels in response to oral glucose tolerance test (120 minutes); LUSC cis rs7824557 0.872 rs6601577 chr8:11102682 C/G cg21775007 chr8:11205619 TDH 0.46 7.01 0.36 1.31e-11 Retinal vascular caliber; LUSC cis rs79839061 0.610 rs17781499 chr4:889384 C/A cg23992470 chr4:843637 GAK 0.59 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); LUSC cis rs8036030 0.604 rs11852686 chr15:74715205 A/G cg14664628 chr15:75095509 CSK -0.39 -5.82 -0.3 1.4e-8 Airflow obstruction; LUSC cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg22920501 chr2:26401640 FAM59B 0.83 11.99 0.55 8.76e-28 Gut microbiome composition (summer); LUSC cis rs796364 0.806 rs10931889 chr2:201101900 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.71 -7.9 -0.4 4.2e-14 Schizophrenia; LUSC cis rs7267979 0.932 rs2260997 chr20:25256266 A/C cg08601574 chr20:25228251 PYGB -0.44 -6.8 -0.35 4.76e-11 Liver enzyme levels (alkaline phosphatase); LUSC cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg26384229 chr12:38710491 ALG10B 0.92 17.63 0.69 1.17e-49 Heart rate; LUSC cis rs41271473 0.526 rs10916339 chr1:228716894 C/T cg16512390 chr1:228756714 NA 0.71 8.99 0.44 1.81e-17 Chronic lymphocytic leukemia; LUSC cis rs7481584 0.581 rs515481 chr11:3047184 A/G cg25174290 chr11:3078921 CARS -0.41 -6.22 -0.32 1.49e-9 Calcium levels; LUSC cis rs9814567 0.686 rs1404289 chr3:134358109 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 13.19 0.59 2.83e-32 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.95 17.3 0.69 2.6e-48 Chronic sinus infection; LUSC cis rs12367572 0.965 rs7952764 chr12:45246211 C/A cg04608330 chr12:45269318 NELL2 -0.58 -9.26 -0.45 2.51e-18 Gut microbiome composition (summer); LUSC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg04553112 chr3:125709451 NA -0.51 -5.75 -0.3 2.06e-8 Blood pressure (smoking interaction); LUSC cis rs6906287 0.647 rs7773274 chr6:118934740 C/G cg21191810 chr6:118973309 C6orf204 0.32 5.91 0.31 8.23e-9 Electrocardiographic conduction measures; LUSC trans rs2204008 0.583 rs12820907 chr12:37990931 T/C cg06521331 chr12:34319734 NA -0.4 -6.32 -0.33 8.19e-10 Bladder cancer; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg05984044 chr4:47034181 GABRB1 0.45 7.01 0.36 1.33e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs11971779 0.680 rs7792752 chr7:139066196 G/C cg07862535 chr7:139043722 LUC7L2 0.56 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; LUSC cis rs977987 0.836 rs35209155 chr16:75470496 G/A cg03315344 chr16:75512273 CHST6 0.5 9.66 0.47 1.22e-19 Dupuytren's disease; LUSC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg16405210 chr4:1374714 KIAA1530 -0.56 -8.52 -0.42 5.41e-16 Obesity-related traits; LUSC cis rs9527 0.590 rs3740386 chr10:104931051 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.53 0.46 3.35e-19 Arsenic metabolism; LUSC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.91 0.31 8.46e-9 Tonsillectomy; LUSC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg05340658 chr4:99064831 C4orf37 0.64 10.77 0.51 2.06e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg21918786 chr6:109611834 NA -0.41 -7.05 -0.36 1.05e-11 Reticulocyte fraction of red cells; LUSC trans rs3942852 0.606 rs10734561 chr11:48097480 C/T cg03929089 chr4:120376271 NA -0.56 -6.82 -0.35 4.18e-11 Acute lymphoblastic leukemia (childhood); LUSC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg08677398 chr8:58056175 NA 0.52 6.67 0.34 1.04e-10 Developmental language disorder (linguistic errors); LUSC cis rs9527 0.590 rs11191578 chr10:104902337 A/T cg23093090 chr10:104574429 C10orf26 -0.35 -6.36 -0.33 6.67e-10 Arsenic metabolism; LUSC cis rs11190604 0.767 rs77769532 chr10:102193646 T/C cg07080220 chr10:102295463 HIF1AN 0.61 8.14 0.41 8.11e-15 Palmitoleic acid (16:1n-7) levels; LUSC cis rs4820539 1.000 rs756631 chr22:23463183 A/G cg21100191 chr22:23484243 RTDR1 0.91 15.61 0.65 1.22e-41 Bone mineral density; LUSC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg04727924 chr7:799746 HEATR2 -0.55 -6.71 -0.34 8.58e-11 Cerebrospinal P-tau181p levels; LUSC cis rs9660992 0.762 rs1172130 chr1:205244953 G/A cg21643547 chr1:205240462 TMCC2 -0.5 -9.46 -0.46 5.79e-19 Mean corpuscular volume;Mean platelet volume; LUSC cis rs208520 0.690 rs207112 chr6:66792092 C/T cg07460842 chr6:66804631 NA -1.13 -17.64 -0.69 1.06e-49 Exhaled nitric oxide output; LUSC cis rs7572644 0.712 rs10204832 chr2:28228408 T/A cg27432699 chr2:27873401 GPN1 -0.52 -6.45 -0.33 3.97e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); LUSC cis rs10504073 0.647 rs11997959 chr8:50014044 C/T cg00325661 chr8:49890786 NA 0.62 10.4 0.49 3.96e-22 Blood metabolite ratios; LUSC cis rs10887741 0.690 rs12772633 chr10:89442492 G/A cg13926569 chr10:89418898 PAPSS2 0.32 6.83 0.35 4.13e-11 Exercise (leisure time); LUSC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg03354898 chr7:1950403 MAD1L1 -0.41 -8.39 -0.42 1.39e-15 Bipolar disorder and schizophrenia; LUSC cis rs1577917 0.876 rs12190735 chr6:86686467 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -8.17 -0.41 6.41e-15 Response to antipsychotic treatment; LUSC cis rs1385374 0.858 rs3741615 chr12:129298848 G/A cg09035930 chr12:129282057 SLC15A4 -0.62 -6.65 -0.34 1.2e-10 Systemic lupus erythematosus; LUSC cis rs2115630 0.967 rs28595395 chr15:85334952 T/C cg11189052 chr15:85197271 WDR73 -0.42 -6.02 -0.31 4.6e-9 P wave terminal force; LUSC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg15485101 chr11:133734466 NA -0.43 -7.93 -0.4 3.28e-14 Childhood ear infection; LUSC trans rs61931739 0.513 rs7956626 chr12:33901640 C/T cg13010199 chr12:38710504 ALG10B 0.46 7.1 0.36 7.36e-12 Morning vs. evening chronotype; LUSC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg03806693 chr22:41940476 POLR3H 1.03 14.3 0.62 1.55e-36 Vitiligo; LUSC cis rs4969178 0.965 rs11077364 chr17:76400337 C/A cg20026190 chr17:76395443 PGS1 0.46 8.16 0.41 6.75e-15 HDL cholesterol levels; LUSC cis rs7605827 0.930 rs6431712 chr2:15691292 C/T cg19274914 chr2:15703543 NA 0.46 8.83 0.44 5.83e-17 Educational attainment (years of education); LUSC cis rs7580658 0.963 rs12991768 chr2:128146245 A/G cg09760422 chr2:128146352 NA -0.34 -7.35 -0.37 1.59e-12 Protein C levels; LUSC cis rs2921073 0.509 rs2976931 chr8:8257317 C/A cg15556689 chr8:8085844 FLJ10661 0.69 11.63 0.54 1.71e-26 Parkinson's disease; LUSC trans rs2204008 0.805 rs12146846 chr12:37985847 C/T cg06521331 chr12:34319734 NA -0.39 -5.98 -0.31 5.82e-9 Bladder cancer; LUSC cis rs4889855 0.545 rs61171555 chr17:78465975 T/G cg16591659 chr17:78472290 NA -0.48 -8.16 -0.41 6.76e-15 Fractional excretion of uric acid; LUSC trans rs941408 1.000 rs1640272 chr19:2800192 A/T cg19676328 chr12:49525230 TUBA1B -0.52 -8.42 -0.42 1.13e-15 Total cholesterol levels; LUSC cis rs6831352 0.918 rs3919370 chr4:100064326 A/T cg12011299 chr4:100065546 ADH4 -0.73 -10.73 -0.51 2.92e-23 Alcohol dependence; LUSC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg08470875 chr2:26401718 FAM59B -0.65 -8.92 -0.44 3.02e-17 Gut microbiome composition (summer); LUSC trans rs6981523 0.553 rs11783045 chr8:11056175 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -7.53 -0.38 4.74e-13 Neuroticism; LUSC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg23630131 chr7:65973040 NA 0.21 5.81 0.3 1.42e-8 Aortic root size; LUSC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg25039879 chr17:56429692 SUPT4H1 0.67 8.85 0.44 5.03e-17 Cognitive test performance; LUSC cis rs2842992 0.747 rs4709379 chr6:160227530 A/G cg11366901 chr6:160182831 ACAT2 0.96 12.23 0.56 1.11e-28 Age-related macular degeneration (geographic atrophy); LUSC cis rs7786808 0.530 rs7785656 chr7:158184164 C/G cg09998033 chr7:158218633 PTPRN2 -0.54 -8.62 -0.43 2.78e-16 Obesity-related traits; LUSC cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg08045932 chr20:61659980 NA 0.59 10.5 0.5 1.76e-22 Prostate cancer (SNP x SNP interaction); LUSC cis rs10203711 0.966 rs4605316 chr2:239595344 C/T cg14580085 chr2:239553406 NA 0.42 7.07 0.36 9.07e-12 Lobe attachment (rater-scored or self-reported); LUSC cis rs763014 0.966 rs4144003 chr16:645968 C/T cg00908189 chr16:619842 PIGQ 0.72 11.22 0.52 5.11e-25 Height; LUSC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg06634786 chr22:41940651 POLR3H 0.51 6.15 0.32 2.18e-9 Vitiligo; LUSC trans rs1814175 0.765 rs11493326 chr11:50018063 T/C cg04017836 chr7:65315216 NA -0.38 -6.01 -0.31 4.99e-9 Height; LUSC trans rs3857536 0.740 rs7763555 chr6:66889930 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.45 -6.26 -0.32 1.19e-9 Blood trace element (Cu levels); LUSC trans rs28735056 0.565 rs12957336 chr18:77716889 A/G cg05926928 chr17:57297772 GDPD1 -0.44 -6.36 -0.33 6.65e-10 Schizophrenia; LUSC cis rs17401966 1.000 rs12407992 chr1:10311983 A/C cg19773385 chr1:10388646 KIF1B -0.56 -8.93 -0.44 2.96e-17 Hepatocellular carcinoma; LUSC trans rs2243480 1.000 rs316332 chr7:65604299 A/G cg10756647 chr7:56101905 PSPH 0.9 9.03 0.44 1.4e-17 Diabetic kidney disease; LUSC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg11764359 chr7:65958608 NA 0.82 13.78 0.6 1.59e-34 Aortic root size; LUSC cis rs9341835 0.772 rs6919709 chr6:64139856 C/T cg03326410 chr6:64151739 NA -0.37 -6.01 -0.31 4.72e-9 Schizophrenia; LUSC cis rs8009147 1 rs8009147 chr14:104264662 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 10.51 0.5 1.69e-22 Autism spectrum disorder or schizophrenia; LUSC cis rs2816062 0.965 rs2816061 chr1:18903819 A/G cg18795169 chr1:18902165 NA 0.9 18.81 0.72 2.35e-54 Urate levels in lean individuals; LUSC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg23158103 chr7:148848205 ZNF398 -0.43 -6.72 -0.35 7.94e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC trans rs11039798 0.841 rs7294179 chr11:48765408 G/A cg03929089 chr4:120376271 NA 0.76 6.37 0.33 6.29e-10 Axial length; LUSC cis rs3008870 1.000 rs3008855 chr1:67386204 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.82 -11.86 -0.54 2.49e-27 Lymphocyte percentage of white cells; LUSC cis rs4919694 0.808 rs4918001 chr10:105013147 G/T cg04362960 chr10:104952993 NT5C2 -1.02 -11.67 -0.54 1.24e-26 Arsenic metabolism; LUSC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.61 0.43 2.91e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs2404602 0.608 rs12911035 chr15:76606591 T/C cg23625390 chr15:77176239 SCAPER 0.47 7.13 0.36 6.25e-12 Blood metabolite levels; LUSC cis rs908922 0.651 rs1885531 chr1:152480233 T/G cg20991723 chr1:152506922 NA 0.51 9.05 0.44 1.22e-17 Hair morphology; LUSC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg14830002 chr1:247616686 OR2B11 -0.55 -8.13 -0.41 8.32e-15 Acute lymphoblastic leukemia (childhood); LUSC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg07424592 chr7:64974309 NA 0.67 5.88 0.31 9.86e-9 Diabetic kidney disease; LUSC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg27572855 chr1:25598939 RHD 0.45 8.07 0.4 1.26e-14 Erythrocyte sedimentation rate; LUSC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg16031515 chr1:205743344 RAB7L1 -0.27 -5.68 -0.3 2.9e-8 Menarche (age at onset); LUSC trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -6.75 -0.35 6.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; LUSC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg18196295 chr10:418757 DIP2C 0.49 8.17 0.41 6.45e-15 Psychosis in Alzheimer's disease; LUSC cis rs2559856 0.935 rs2559864 chr12:102084710 C/G cg12924262 chr12:102091054 CHPT1 0.43 5.99 0.31 5.47e-9 Blood protein levels; LUSC cis rs2952156 0.959 rs2941503 chr17:37828745 A/G cg00129232 chr17:37814104 STARD3 -0.43 -6.34 -0.33 7.36e-10 Asthma; LUSC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg06600287 chr1:53387719 ECHDC2 -0.3 -6.23 -0.32 1.43e-9 Monocyte count; LUSC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg16434002 chr17:42200994 HDAC5 0.45 6.0 0.31 5.13e-9 Total body bone mineral density; LUSC cis rs877282 0.898 rs11253353 chr10:766862 C/A cg17470449 chr10:769945 NA 0.5 6.42 0.33 4.68e-10 Uric acid levels; LUSC cis rs7103648 0.669 rs10437655 chr11:47391948 G/A cg20307385 chr11:47447363 PSMC3 0.93 17.34 0.69 1.67e-48 Diastolic blood pressure;Systolic blood pressure; LUSC cis rs5769707 0.967 rs9616713 chr22:50049109 G/A cg10356904 chr22:49881777 NA -0.34 -7.53 -0.38 4.85e-13 Monocyte count;Monocyte percentage of white cells; LUSC trans rs2587949 0.615 rs1087727 chr3:4204974 A/G cg15139668 chr4:4577005 NA -0.41 -6.08 -0.32 3.33e-9 Periodontitis (DPAL); LUSC cis rs10875746 0.951 rs8804 chr12:48541757 A/G cg13454099 chr12:49076203 C12orf41 -0.51 -6.02 -0.31 4.61e-9 Longevity (90 years and older); LUSC cis rs11756438 0.572 rs1844964 chr6:119002528 C/T cg18833306 chr6:118973337 C6orf204 0.36 5.75 0.3 2.05e-8 QT interval;Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs7615316 1.000 rs2177396 chr3:142343401 A/G cg16271453 chr3:142027066 XRN1 -0.36 -6.07 -0.32 3.52e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs9905704 0.681 rs4793948 chr17:56562062 G/A cg19466818 chr17:56409534 MIR142 0.35 6.5 0.34 2.94e-10 Testicular germ cell tumor; LUSC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18758796 chr5:131593413 PDLIM4 0.47 7.59 0.38 3.13e-13 Acylcarnitine levels; LUSC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg03060546 chr3:49711283 APEH 0.49 6.59 0.34 1.68e-10 Subjective well-being (multi-trait analysis);Menarche (age at onset); LUSC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg17330251 chr7:94953956 PON1 -0.41 -6.63 -0.34 1.35e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs56399783 0.901 rs11971014 chr7:2778444 C/T cg14895029 chr7:2775587 GNA12 0.51 5.73 0.3 2.22e-8 Childhood ear infection; LUSC cis rs7945718 0.781 rs11022505 chr11:12822366 A/G cg25843174 chr11:12811716 TEAD1 -0.31 -7.09 -0.36 7.98e-12 Educational attainment (years of education); LUSC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg06008330 chr7:65541103 ASL -0.4 -6.16 -0.32 2.14e-9 Aortic root size; LUSC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg03240473 chr21:43526662 UMODL1;C21orf128 -0.59 -9.57 -0.46 2.41e-19 IgG glycosylation; LUSC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg03676636 chr4:99064102 C4orf37 0.38 7.96 0.4 2.68e-14 Colonoscopy-negative controls vs population controls; LUSC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg20135002 chr11:47629003 NA 0.49 7.8 0.39 8.06e-14 Subjective well-being; LUSC cis rs11971779 0.680 rs2355783 chr7:139075879 C/T cg23387468 chr7:139079360 LUC7L2 0.41 6.27 0.32 1.13e-9 Diisocyanate-induced asthma; LUSC cis rs3812111 0.510 rs4946151 chr6:116595289 G/C cg18828861 chr6:116576566 TSPYL4 0.38 6.57 0.34 1.96e-10 Age-related macular degeneration; LUSC cis rs8078723 0.866 rs7502514 chr17:38188844 A/G cg17467752 chr17:38218738 THRA -0.82 -13.57 -0.6 1.05e-33 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs2760061 0.583 rs708121 chr1:228208257 A/G cg02753203 chr1:228287806 NA 1.0 19.9 0.74 1.12e-58 Diastolic blood pressure; LUSC trans rs208520 1.000 rs12190187 chr6:66973207 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 12.22 0.56 1.23e-28 Exhaled nitric oxide output; LUSC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg12311346 chr5:56204834 C5orf35 -0.99 -14.45 -0.62 4.26e-37 Initial pursuit acceleration; LUSC cis rs17401966 0.838 rs4846209 chr1:10322054 G/A cg19773385 chr1:10388646 KIF1B -0.51 -8.81 -0.43 6.93e-17 Hepatocellular carcinoma; LUSC cis rs7927592 0.513 rs630225 chr11:68194611 A/C cg20283391 chr11:68216788 NA -0.5 -6.99 -0.36 1.46e-11 Total body bone mineral density; LUSC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg06850241 chr22:41845214 NA 0.34 6.37 0.33 6.21e-10 Vitiligo; LUSC trans rs1994135 0.692 rs1816958 chr12:33695066 A/T cg26384229 chr12:38710491 ALG10B 0.6 8.41 0.42 1.2e-15 Resting heart rate; LUSC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg22638593 chr5:131593259 PDLIM4 -0.45 -6.52 -0.34 2.61e-10 Acylcarnitine levels; LUSC cis rs17102423 0.731 rs10143198 chr14:65555471 C/T cg11161011 chr14:65562177 MAX -0.67 -10.17 -0.49 2.43e-21 Obesity-related traits; LUSC cis rs6693567 0.565 rs834238 chr1:150366469 G/T cg15654264 chr1:150340011 RPRD2 0.47 7.49 0.38 6.37e-13 Migraine; LUSC cis rs6964587 1.000 rs28584017 chr7:91719168 G/A cg17063962 chr7:91808500 NA 0.59 9.25 0.45 2.65e-18 Breast cancer; LUSC trans rs62103177 0.525 rs4799116 chr18:77736735 A/G cg05926928 chr17:57297772 GDPD1 -0.85 -9.8 -0.47 4.43e-20 Opioid sensitivity; LUSC cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -11.86 -0.54 2.57e-27 Chronic sinus infection; LUSC cis rs4845459 1.000 rs6702463 chr1:152598711 A/T cg08895932 chr1:152778580 LCE1C -0.36 -6.04 -0.31 4.12e-9 Psoriasis; LUSC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg21862992 chr11:68658383 NA 0.52 8.08 0.4 1.23e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs8056893 0.842 rs3785114 chr16:68372323 C/G cg02226672 chr16:68398533 SMPD3 0.32 5.84 0.3 1.23e-8 Blood metabolite ratios;Glomerular filtration rate (creatinine);Blood metabolite levels; LUSC trans rs4252134 0.959 rs4252096 chr6:161134273 C/G cg00639886 chr12:54943102 PDE1B -0.44 -6.33 -0.33 7.8e-10 Giant cell arteritis; LUSC cis rs2832077 0.506 rs2832085 chr21:30155258 G/T cg08807101 chr21:30365312 RNF160 -0.49 -6.49 -0.33 3.01e-10 Cognitive test performance; LUSC cis rs7824557 0.767 rs11250127 chr8:11170209 G/A cg27411982 chr8:10470053 RP1L1 0.38 5.89 0.31 9.35e-9 Retinal vascular caliber; LUSC cis rs7177699 0.525 rs56076311 chr15:79115120 A/G cg15571903 chr15:79123663 NA -0.33 -6.16 -0.32 2.06e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; LUSC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg21433313 chr16:3507492 NAT15 0.4 5.69 0.3 2.81e-8 Body mass index (adult); LUSC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg15556689 chr8:8085844 FLJ10661 0.78 13.27 0.59 1.4e-32 Systolic blood pressure; LUSC cis rs5769765 0.954 rs910799 chr22:50278568 A/G cg26441486 chr22:50317300 CRELD2 -0.53 -7.92 -0.4 3.57e-14 Schizophrenia; LUSC cis rs10170846 0.893 rs1447108 chr2:223542231 A/G cg25565276 chr2:223520875 FARSB 0.62 9.38 0.46 1.02e-18 Schizophrenia (inflammation and infection response interaction); LUSC cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg21573476 chr21:45109991 RRP1B 0.44 7.11 0.36 7.27e-12 Mean corpuscular volume; LUSC cis rs453301 0.657 rs36056437 chr8:8792865 T/G cg08975724 chr8:8085496 FLJ10661 -0.4 -5.8 -0.3 1.57e-8 Joint mobility (Beighton score); LUSC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg13560548 chr3:10150139 C3orf24 0.5 7.05 0.36 1.01e-11 Alzheimer's disease; LUSC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg23758822 chr17:41437982 NA 0.99 18.65 0.71 1.02e-53 Menopause (age at onset); LUSC cis rs854765 0.583 rs11650649 chr17:17790319 C/A cg16928487 chr17:17741425 SREBF1 0.45 8.81 0.43 6.79e-17 Total body bone mineral density; LUSC cis rs9611519 1.000 rs5758264 chr22:41616284 T/G cg03806693 chr22:41940476 POLR3H -0.5 -6.91 -0.35 2.45e-11 Neuroticism; LUSC cis rs76878669 0.561 rs7940980 chr11:66172910 C/T cg24851651 chr11:66362959 CCS 0.39 5.95 0.31 6.77e-9 Educational attainment (years of education); LUSC cis rs2303282 0.716 rs2432538 chr16:56421427 A/G cg00500540 chr16:56394104 NA -0.43 -7.32 -0.37 1.84e-12 Breast cancer; LUSC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg23958373 chr8:599963 NA 0.83 8.86 0.44 4.77e-17 IgG glycosylation; LUSC trans rs9329221 0.648 rs4512422 chr8:10258889 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.57 -0.34 1.98e-10 Neuroticism; LUSC cis rs17095355 0.901 rs28365866 chr10:111767214 C/T cg00817464 chr10:111662876 XPNPEP1 -0.61 -6.84 -0.35 3.8e-11 Biliary atresia; LUSC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 12.32 0.56 5.38e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs11190604 1.000 rs2495747 chr10:102328247 C/T cg16342193 chr10:102329863 NA -0.37 -6.72 -0.35 7.86e-11 Palmitoleic acid (16:1n-7) levels; LUSC cis rs9378688 0.654 rs2450307 chr6:2324639 A/G cg12303981 chr6:2244766 GMDS -0.41 -5.77 -0.3 1.84e-8 Caudate nucleus volume; LUSC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg27165867 chr14:105738592 BRF1 -0.55 -8.17 -0.41 6.52e-15 Mean platelet volume;Platelet distribution width; LUSC trans rs6952808 0.723 rs57216949 chr7:2030287 G/T cg04565464 chr8:145669602 NFKBIL2 0.39 6.38 0.33 5.85e-10 Bipolar disorder and schizophrenia; LUSC cis rs12220238 0.908 rs10824077 chr10:75887038 C/T cg19889307 chr10:75911429 ADK;AP3M1 -0.63 -7.75 -0.39 1.14e-13 Soluble interleukin-2 receptor subunit alpha; LUSC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg04944784 chr2:26401820 FAM59B -0.69 -9.63 -0.47 1.61e-19 Gut microbiome composition (summer); LUSC trans rs75804782 0.641 rs60841092 chr2:239349640 G/A cg01134436 chr17:81009848 B3GNTL1 0.66 6.28 0.32 1.02e-9 Morning vs. evening chronotype;Chronotype; LUSC trans rs7824557 0.583 rs6601585 chr8:11233659 A/G cg15556689 chr8:8085844 FLJ10661 -0.54 -8.14 -0.41 7.68e-15 Retinal vascular caliber; LUSC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg26338869 chr17:61819248 STRADA 0.42 6.08 0.32 3.25e-9 Prudent dietary pattern; LUSC cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.01 0.55 7.43e-28 Colorectal cancer; LUSC cis rs939574 0.818 rs6744146 chr2:220070597 T/A cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.95 -8.17 -0.41 6.53e-15 Platelet distribution width; LUSC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg11062466 chr8:58055876 NA 0.48 5.68 0.3 2.93e-8 Developmental language disorder (linguistic errors); LUSC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -18.93 -0.72 8.57e-55 Height; LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.9 12.7 0.57 2.07e-30 Platelet count; LUSC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg20896738 chr21:46707857 POFUT2;LOC642852 0.44 6.04 0.31 4.18e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC cis rs3806843 1.000 rs10038174 chr5:140210616 G/A cg19875535 chr5:140030758 IK 0.45 7.17 0.37 4.9e-12 Depressive symptoms (multi-trait analysis); LUSC cis rs6430585 0.697 rs115944351 chr2:136515458 G/A cg07169764 chr2:136633963 MCM6 1.18 17.48 0.69 4.99e-49 Corneal structure; LUSC cis rs10465746 0.780 rs12139191 chr1:84387871 A/C cg10977910 chr1:84465055 TTLL7 0.44 6.36 0.33 6.81e-10 Obesity-related traits; LUSC trans rs13011075 0.881 rs7597167 chr2:68612946 C/T cg14221825 chr19:46271408 SIX5 0.43 6.17 0.32 1.95e-9 Mean corpuscular volume; LUSC cis rs6541297 0.699 rs12065546 chr1:230295245 C/T cg05784532 chr1:230284198 GALNT2 0.55 6.3 0.33 9.26e-10 Coronary artery disease; LUSC trans rs61931739 0.500 rs11053185 chr12:34428857 A/G cg26384229 chr12:38710491 ALG10B 0.78 13.3 0.59 1.11e-32 Morning vs. evening chronotype; LUSC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg05340658 chr4:99064831 C4orf37 0.66 11.23 0.52 4.91e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs6960043 0.818 rs10807778 chr7:15054190 C/G cg19272540 chr7:15055459 NA 0.33 8.13 0.41 8.38e-15 Type 2 diabetes; LUSC trans rs6561151 0.957 rs2121034 chr13:44473866 G/T cg12856521 chr11:46389249 DGKZ 0.57 7.44 0.38 8.69e-13 Crohn's disease; LUSC cis rs10782582 0.609 rs78776851 chr1:76424845 T/C cg10523679 chr1:76189770 ACADM -0.43 -6.04 -0.31 4.17e-9 Daytime sleep phenotypes; LUSC cis rs11098499 0.954 rs28572238 chr4:120316686 T/G cg24375607 chr4:120327624 NA 0.75 10.76 0.51 2.15e-23 Corneal astigmatism; LUSC trans rs11098499 0.913 rs10010696 chr4:120164303 T/C cg25214090 chr10:38739885 LOC399744 0.48 6.87 0.35 3.07e-11 Corneal astigmatism; LUSC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg25838465 chr1:92012736 NA 0.7 13.6 0.6 8.17e-34 Breast cancer; LUSC cis rs9640161 0.783 rs2021871 chr7:150071156 T/C cg27494647 chr7:150038898 RARRES2 0.36 5.8 0.3 1.52e-8 Blood protein levels;Circulating chemerin levels; LUSC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg21361702 chr7:150065534 REPIN1 0.52 6.74 0.35 6.77e-11 Blood protein levels;Circulating chemerin levels; LUSC cis rs11809207 1.000 rs34587428 chr1:26522392 C/T cg00147160 chr1:26503991 CNKSR1 0.42 6.96 0.36 1.8e-11 Height; LUSC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg08439880 chr3:133502540 NA 0.32 5.76 0.3 1.88e-8 Iron status biomarkers; LUSC cis rs6121246 0.529 rs58757492 chr20:30181425 G/A cg18721089 chr20:30220636 NA -0.39 -6.15 -0.32 2.2e-9 Mean corpuscular hemoglobin; LUSC cis rs2249625 0.545 rs2249021 chr6:72889472 A/G cg18830697 chr6:72922368 RIMS1 -0.37 -7.38 -0.37 1.25e-12 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); LUSC cis rs6494488 0.500 rs72744730 chr15:65040065 C/G cg08069370 chr15:64387884 SNX1 -0.66 -5.76 -0.3 1.89e-8 Coronary artery disease; LUSC cis rs1577917 0.740 rs7771612 chr6:86264374 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.46 7.39 0.38 1.16e-12 Response to antipsychotic treatment; LUSC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg12823233 chr7:2316876 SNX8 -0.36 -6.01 -0.31 4.92e-9 Schizophrenia, schizoaffective disorder or bipolar disorder; LUSC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg04944784 chr2:26401820 FAM59B -0.68 -9.49 -0.46 4.49e-19 Gut microbiome composition (summer); LUSC cis rs7824557 0.583 rs2736306 chr8:11239762 A/T cg21775007 chr8:11205619 TDH 0.63 9.57 0.46 2.57e-19 Retinal vascular caliber; LUSC cis rs2282802 0.685 rs2337081 chr5:139642414 A/C cg26211634 chr5:139558579 C5orf32 0.44 8.3 0.41 2.59e-15 Intelligence (multi-trait analysis); LUSC cis rs3806843 1.000 rs3733708 chr5:140181734 A/G cg26395211 chr5:140044315 WDR55 -0.37 -5.72 -0.3 2.37e-8 Depressive symptoms (multi-trait analysis); LUSC cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.52 7.77 0.39 9.78e-14 Spherical equivalent (joint analysis main effects and education interaction); LUSC trans rs1814175 0.765 rs11493326 chr11:50018063 T/C cg15704280 chr7:45808275 SEPT13 -1.12 -24.13 -0.8 3.54e-75 Height; LUSC trans rs35110281 0.627 rs1436291 chr21:44965485 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.6 10.6 0.5 8.29e-23 Mean corpuscular volume; LUSC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg00745463 chr17:30367425 LRRC37B -0.7 -8.52 -0.42 5.45e-16 Hip circumference adjusted for BMI; LUSC cis rs11676348 0.846 rs3890158 chr2:218990292 G/A cg06547715 chr2:218990976 CXCR2 0.33 6.45 0.33 3.93e-10 Ulcerative colitis; LUSC cis rs6964587 1.000 rs9690778 chr7:91735299 A/G cg01689657 chr7:91764605 CYP51A1 0.35 6.3 0.33 9.48e-10 Breast cancer; LUSC cis rs6681460 0.932 rs2044400 chr1:67054081 T/A cg02459107 chr1:67143332 SGIP1 0.46 8.43 0.42 1.04e-15 Presence of antiphospholipid antibodies; LUSC cis rs1957429 0.901 rs1957434 chr14:65349909 C/T cg23373153 chr14:65346875 NA 1.07 12.89 0.58 3.85e-31 Pediatric areal bone mineral density (radius); LUSC trans rs4843747 0.671 rs9933794 chr16:88116981 T/C cg26811252 chr16:29126840 RRN3P2 0.6 9.61 0.47 1.78e-19 Menopause (age at onset); LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg19302295 chr19:14228590 PRKACA 0.64 5.99 0.31 5.39e-9 Cognitive performance; LUSC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg03351412 chr1:154909251 PMVK 0.55 8.7 0.43 1.52e-16 Prostate cancer; LUSC trans rs7647973 0.626 rs1996663 chr3:49878264 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.61 6.89 0.35 2.74e-11 Menarche (age at onset); LUSC cis rs17253792 0.822 rs10129890 chr14:56040413 A/T cg01858014 chr14:56050164 KTN1 -0.76 -6.24 -0.32 1.32e-9 Putamen volume; LUSC trans rs2055729 0.645 rs7828229 chr8:9742841 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -6.92 -0.35 2.38e-11 Multiple myeloma (hyperdiploidy); LUSC cis rs9303401 0.659 rs35797125 chr17:56736547 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.86 13.61 0.6 7.09e-34 Cognitive test performance; LUSC cis rs7246657 0.943 rs10405064 chr19:37861861 C/T cg23950597 chr19:37808831 NA -0.63 -7.6 -0.38 2.95e-13 Coronary artery calcification; LUSC cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg26384229 chr12:38710491 ALG10B 0.93 15.96 0.66 5.05e-43 Morning vs. evening chronotype; LUSC cis rs72634258 0.786 rs6577468 chr1:8183921 T/C cg00042356 chr1:8021962 PARK7 0.61 7.42 0.38 9.56e-13 Inflammatory bowel disease; LUSC cis rs6121246 0.559 rs6087782 chr20:30391580 C/T cg13852791 chr20:30311386 BCL2L1 0.93 14.41 0.62 5.98e-37 Mean corpuscular hemoglobin; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg11242200 chr8:22857399 RHOBTB2 -0.42 -6.43 -0.33 4.43e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs4604732 0.588 rs7552443 chr1:247628583 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.44 6.78 0.35 5.42e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); LUSC cis rs854765 0.575 rs2955357 chr17:17946401 T/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.79 -14.52 -0.62 2.23e-37 Total body bone mineral density; LUSC cis rs6723226 0.767 rs10172308 chr2:32555760 G/A cg02381751 chr2:32503542 YIPF4 -0.63 -9.7 -0.47 9.04e-20 Intelligence (multi-trait analysis); LUSC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg06008330 chr7:65541103 ASL 0.41 6.31 0.33 8.79e-10 Aortic root size; LUSC cis rs9814567 1.000 rs934093 chr3:134195885 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -13.74 -0.6 2.39e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); LUSC cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg26408565 chr15:76604113 ETFA -0.43 -6.85 -0.35 3.64e-11 Blood metabolite levels; LUSC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg05084668 chr3:125655381 ALG1L -0.49 -6.89 -0.35 2.86e-11 Blood pressure (smoking interaction); LUSC cis rs7241530 0.662 rs35308826 chr18:75903736 T/C cg14642773 chr18:75888474 NA 0.39 6.02 0.31 4.59e-9 Educational attainment (years of education); LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg02205746 chr16:2732724 KCTD5 -0.5 -6.6 -0.34 1.62e-10 Bipolar disorder and schizophrenia; LUSC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.38 -7.98 -0.4 2.29e-14 Hemoglobin concentration; LUSC cis rs17539620 0.624 rs62432735 chr6:154834055 T/C cg20019720 chr6:154832845 CNKSR3 0.63 8.56 0.42 4.17e-16 Lipoprotein (a) levels; LUSC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg18904891 chr8:8559673 CLDN23 0.54 7.48 0.38 6.58e-13 Obesity-related traits; LUSC cis rs11785400 0.731 rs9720504 chr8:143725502 T/C cg24634471 chr8:143751801 JRK 0.51 7.21 0.37 3.71e-12 Schizophrenia; LUSC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg21724239 chr8:58056113 NA 0.78 9.44 0.46 6.76e-19 Developmental language disorder (linguistic errors); LUSC trans rs10211296 0.584 rs13389345 chr2:166455078 A/G cg01325958 chr17:37793326 STARD3 0.41 5.94 0.31 6.99e-9 Risky sexual behaviors in alcohol dependence; LUSC trans rs4714291 0.832 rs761798 chr6:40087514 C/T cg02267698 chr19:7991119 CTXN1 0.57 8.8 0.43 7.51e-17 Strep throat; LUSC cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg23711669 chr6:146136114 FBXO30 0.91 17.28 0.69 3e-48 Lobe attachment (rater-scored or self-reported); LUSC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg09034736 chr1:150693464 HORMAD1 0.45 6.25 0.32 1.25e-9 Melanoma; LUSC cis rs899997 1.000 rs11629824 chr15:79005524 T/G cg04896959 chr15:78267971 NA 0.52 11.03 0.52 2.56e-24 Coronary artery disease or large artery stroke; LUSC cis rs7113850 0.541 rs75893426 chr11:24210429 T/C ch.11.24196551F chr11:24239977 NA 0.98 7.5 0.38 5.69e-13 Bone fracture in osteoporosis; LUSC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg09904177 chr6:26538194 HMGN4 0.48 7.01 0.36 1.37e-11 Autism spectrum disorder or schizophrenia; LUSC cis rs2235642 0.821 rs2281234 chr16:1602938 A/G cg09025071 chr16:1593152 IFT140;TMEM204 0.29 6.54 0.34 2.27e-10 Coronary artery disease; LUSC cis rs6500602 0.727 rs4786510 chr16:4571247 A/G cg08645402 chr16:4508243 NA 0.53 8.98 0.44 2.03e-17 Schizophrenia; LUSC cis rs6543140 0.572 rs17027173 chr2:103057043 G/A cg09003973 chr2:102972529 NA 0.71 8.24 0.41 3.86e-15 Blood protein levels; LUSC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg13877915 chr19:58951672 ZNF132 0.49 7.75 0.39 1.11e-13 Uric acid clearance; LUSC cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg00071950 chr4:10020882 SLC2A9 0.62 10.66 0.5 5e-23 Bone mineral density; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg01573445 chr19:45927190 ERCC1 -0.47 -6.21 -0.32 1.57e-9 Hepatitis; LUSC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.92 -13.0 -0.58 1.52e-31 Platelet count; LUSC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg19046167 chr17:80928561 B3GNTL1 0.44 7.07 0.36 9.38e-12 Breast cancer; LUSC cis rs722599 0.748 rs2300599 chr14:75359441 A/G cg06637938 chr14:75390232 RPS6KL1 -0.4 -5.77 -0.3 1.77e-8 IgG glycosylation; LUSC cis rs2346177 0.811 rs4953373 chr2:46652145 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.57 -8.9 -0.44 3.63e-17 HDL cholesterol; LUSC cis rs804280 1.000 rs804280 chr8:11612698 G/T cg21775007 chr8:11205619 TDH 0.43 6.16 0.32 2.1e-9 Myopia (pathological); LUSC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg08493051 chr2:3487164 NA -0.56 -8.66 -0.43 2.12e-16 Neurofibrillary tangles; LUSC cis rs11758351 1.000 rs41266807 chr6:26199822 A/G cg01420254 chr6:26195488 NA 0.69 7.35 0.37 1.53e-12 Gout;Renal underexcretion gout; LUSC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11644478 chr21:40555479 PSMG1 0.93 18.29 0.71 2.88e-52 Cognitive function; LUSC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.45 6.92 0.35 2.32e-11 Intelligence (multi-trait analysis); LUSC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg11764359 chr7:65958608 NA 0.7 10.66 0.5 5e-23 Aortic root size; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19560692 chr2:20646664 RHOB -0.44 -6.41 -0.33 4.97e-10 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg05340658 chr4:99064831 C4orf37 0.64 10.53 0.5 1.4e-22 Colonoscopy-negative controls vs population controls; LUSC cis rs61931739 0.534 rs7302688 chr12:34235064 A/G cg06521331 chr12:34319734 NA -0.46 -7.69 -0.39 1.71e-13 Morning vs. evening chronotype; LUSC cis rs7615316 0.751 rs9289647 chr3:142032483 G/A cg16271453 chr3:142027066 XRN1 -0.4 -6.94 -0.36 2.04e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg20891283 chr12:69753455 YEATS4 0.91 17.45 0.69 6.11e-49 Cerebrospinal fluid biomarker levels; LUSC cis rs11039100 0.607 rs11038944 chr11:5778930 C/T cg05234568 chr11:5960015 NA -0.42 -5.67 -0.3 3.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs4654899 0.643 rs12145181 chr1:21086046 C/A cg01072550 chr1:21505969 NA -0.47 -7.04 -0.36 1.07e-11 Superior frontal gyrus grey matter volume; LUSC cis rs2219968 1.000 rs7003907 chr8:78976336 A/G cg00738934 chr8:78996279 NA 0.35 6.3 0.33 9.41e-10 Prostate cancer (SNP x SNP interaction); LUSC cis rs1215050 0.740 rs783936 chr4:98928628 G/T cg05340658 chr4:99064831 C4orf37 -0.46 -7.3 -0.37 2.1e-12 Waist-to-hip ratio adjusted for body mass index; LUSC cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg22709100 chr7:91322751 NA 0.39 5.86 0.31 1.13e-8 Breast cancer; LUSC cis rs12618769 1.000 rs72825720 chr2:99247508 T/C cg10123293 chr2:99228465 UNC50 0.42 5.75 0.3 1.96e-8 Bipolar disorder; LUSC cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.59 -0.43 3.46e-16 Body mass index; LUSC cis rs8060686 0.641 rs1125333 chr16:68227566 C/A cg27539214 chr16:67997921 SLC12A4 -0.57 -7.21 -0.37 3.78e-12 HDL cholesterol;Metabolic syndrome; LUSC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg09365446 chr1:150670422 GOLPH3L 0.55 7.87 0.4 5.01e-14 Urate levels; LUSC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg17633681 chr16:88106987 BANP 0.53 10.18 0.49 2.24e-21 Menopause (age at onset); LUSC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg22029157 chr1:209979665 IRF6 0.73 8.96 0.44 2.42e-17 Cleft lip with or without cleft palate; LUSC cis rs7315438 0.600 rs1874893 chr12:115886473 A/G cg24172291 chr12:115889509 NA 0.35 5.99 0.31 5.34e-9 Colorectal cancer; LUSC cis rs9905704 0.881 rs695137 chr17:56776663 G/A cg12560992 chr17:57184187 TRIM37 0.56 8.01 0.4 1.92e-14 Testicular germ cell tumor; LUSC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg19622623 chr12:86230825 RASSF9 0.43 5.99 0.31 5.39e-9 Major depressive disorder; LUSC cis rs5769707 0.681 rs1107514 chr22:50042383 T/C cg20744362 chr22:50050164 C22orf34 0.37 6.85 0.35 3.55e-11 Monocyte count;Monocyte percentage of white cells; LUSC cis rs4474465 0.915 rs7123060 chr11:78208634 A/G cg27205649 chr11:78285834 NARS2 0.51 5.89 0.31 9.2e-9 Alzheimer's disease (survival time); LUSC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.53 8.38 0.42 1.54e-15 Prudent dietary pattern; LUSC cis rs10979 1.000 rs6905264 chr6:143894378 A/G cg25407410 chr6:143891975 LOC285740 -0.74 -12.25 -0.56 9.15e-29 Hypospadias; LUSC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.8 0.6 1.34e-34 Alzheimer's disease; LUSC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -11.06 -0.52 1.96e-24 Alzheimer's disease; LUSC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg22907277 chr7:1156413 C7orf50 0.7 7.6 0.38 3.08e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs17102423 0.755 rs7143495 chr14:65546361 C/T cg11161011 chr14:65562177 MAX 0.77 12.18 0.55 1.76e-28 Obesity-related traits; LUSC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg23985595 chr17:80112537 CCDC57 -0.33 -6.52 -0.34 2.6e-10 Life satisfaction; LUSC cis rs10887741 0.690 rs12772633 chr10:89442492 G/A cg24243914 chr10:89418206 PAPSS2 0.32 6.14 0.32 2.39e-9 Exercise (leisure time); LUSC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg20203395 chr5:56204925 C5orf35 -0.76 -10.12 -0.48 3.5e-21 Initial pursuit acceleration; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg09060823 chr12:56862504 SPRYD4 0.42 5.98 0.31 5.67e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7267979 0.868 rs6107019 chr20:25233985 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.79 16.21 0.66 5.1e-44 Liver enzyme levels (alkaline phosphatase); LUSC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.64 6.3 0.33 9.2e-10 Cerebrospinal P-tau181p levels; LUSC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg04756594 chr16:24857601 SLC5A11 -0.37 -6.21 -0.32 1.61e-9 Intelligence (multi-trait analysis); LUSC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -11.9 -0.55 1.77e-27 Hemoglobin concentration; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg23260799 chr11:451101 PTDSS2 0.47 6.62 0.34 1.39e-10 Cognitive function;Information processing speed; LUSC cis rs67460515 0.892 rs1478566 chr3:161030335 A/T cg03342759 chr3:160939853 NMD3 -0.53 -7.56 -0.38 3.97e-13 Parkinson's disease; LUSC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg25067162 chr17:41277974 BRCA1;NBR2 0.36 6.05 0.31 3.95e-9 Menopause (age at onset); LUSC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg25258033 chr6:167368657 RNASET2 -0.47 -7.78 -0.39 9.43e-14 Crohn's disease; LUSC cis rs2635047 0.967 rs7242978 chr18:44633424 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.47 -7.28 -0.37 2.49e-12 Educational attainment; LUSC cis rs7903847 0.619 rs9888116 chr10:99159482 G/A cg20016023 chr10:99160130 RRP12 -0.32 -7.86 -0.4 5.34e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg06637938 chr14:75390232 RPS6KL1 0.51 7.81 0.39 7.28e-14 Height; LUSC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg10802521 chr3:52805072 NEK4 -0.57 -9.3 -0.45 1.87e-18 Electroencephalogram traits; LUSC cis rs11048434 0.761 rs2110191 chr12:9136263 G/A cg23795048 chr12:9217529 LOC144571 0.34 5.88 0.31 9.84e-9 Sjögren's syndrome; LUSC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg12292205 chr6:26970375 C6orf41 0.66 11.24 0.52 4.54e-25 Autism spectrum disorder or schizophrenia; LUSC cis rs6831352 0.840 rs34634551 chr4:100067362 C/A cg13256891 chr4:100009986 ADH5 -0.5 -6.47 -0.33 3.53e-10 Alcohol dependence; LUSC cis rs72781680 0.898 rs113027486 chr2:24098371 G/A cg20701182 chr2:24300061 SF3B14 0.54 5.78 0.3 1.75e-8 Lymphocyte counts; LUSC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg15445000 chr17:37608096 MED1 0.4 6.72 0.35 7.92e-11 Glomerular filtration rate (creatinine); LUSC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg11344533 chr11:111475393 SIK2 -0.48 -6.58 -0.34 1.78e-10 Primary sclerosing cholangitis; LUSC cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg23583168 chr7:148888333 NA -0.82 -14.34 -0.62 1.15e-36 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg02376097 chr19:46275166 DMPK 0.4 7.15 0.36 5.51e-12 Coronary artery disease; LUSC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg17178900 chr1:205818956 PM20D1 0.47 7.26 0.37 2.73e-12 Menarche (age at onset); LUSC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg24250549 chr1:154909240 PMVK -0.57 -9.14 -0.45 6.2e-18 Prostate cancer; LUSC cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg12219531 chr12:120966889 COQ5 0.62 8.31 0.41 2.42e-15 High light scatter reticulocyte count; LUSC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg02569458 chr12:86230093 RASSF9 0.59 9.97 0.48 1.15e-20 Major depressive disorder; LUSC trans rs9443189 0.530 rs614065 chr6:76315633 G/A cg06762398 chr15:78372177 NA 0.49 6.02 0.31 4.52e-9 Prostate cancer; LUSC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 11.84 0.54 3.07e-27 Platelet count; LUSC cis rs72634258 0.786 rs9434991 chr1:8178708 G/C cg00042356 chr1:8021962 PARK7 0.54 6.61 0.34 1.55e-10 Inflammatory bowel disease; LUSC cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg12751644 chr20:60527061 NA -0.34 -6.32 -0.33 8.23e-10 Body mass index; LUSC trans rs61931739 0.534 rs12371021 chr12:34062252 T/C cg13010199 chr12:38710504 ALG10B 0.56 8.59 0.43 3.45e-16 Morning vs. evening chronotype; LUSC cis rs9837602 1.000 rs9837602 chr3:99824685 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.42 -6.11 -0.32 2.78e-9 Breast cancer; LUSC cis rs7681440 0.904 rs6532193 chr4:90764188 G/A cg01966878 chr4:90757139 SNCA -0.36 -6.22 -0.32 1.52e-9 Dementia with Lewy bodies; LUSC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg08847533 chr14:75593920 NEK9 0.69 10.66 0.5 5.01e-23 Height; LUSC cis rs4474465 1.000 rs7935292 chr11:78169885 C/G cg27205649 chr11:78285834 NARS2 -0.48 -5.74 -0.3 2.12e-8 Alzheimer's disease (survival time); LUSC cis rs9341808 0.935 rs2298307 chr6:80816296 A/G cg08355045 chr6:80787529 NA 0.51 8.94 0.44 2.68e-17 Sitting height ratio; LUSC trans rs11098499 0.863 rs3775845 chr4:120432447 T/C cg25214090 chr10:38739885 LOC399744 0.5 7.39 0.37 1.19e-12 Corneal astigmatism; LUSC cis rs897080 0.514 rs1067376 chr2:44648361 A/G cg00619915 chr2:44497795 NA -0.42 -6.0 -0.31 5.23e-9 Height; LUSC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg23172400 chr8:95962367 TP53INP1 -0.43 -8.97 -0.44 2.21e-17 Type 2 diabetes; LUSC cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg00012203 chr2:219082015 ARPC2 0.71 11.8 0.54 4.15e-27 Colorectal cancer; LUSC cis rs7590720 0.959 rs2372684 chr2:216884764 C/A cg12620499 chr2:216877984 MREG 0.93 13.93 0.61 4.15e-35 Alcohol dependence; LUSC cis rs7617773 0.780 rs13067450 chr3:48337206 C/T cg20734569 chr3:48348370 SPINK8 -0.46 -7.81 -0.39 7.43e-14 Coronary artery disease; LUSC cis rs11690935 0.959 rs6738445 chr2:172599615 T/C cg13550731 chr2:172543902 DYNC1I2 0.83 13.25 0.59 1.66e-32 Schizophrenia; LUSC cis rs7903847 0.596 rs7922512 chr10:99155685 C/A cg20016023 chr10:99160130 RRP12 -0.32 -7.99 -0.4 2.16e-14 Granulocyte percentage of myeloid white cells; LUSC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg18827107 chr12:86230957 RASSF9 -0.48 -7.18 -0.37 4.63e-12 Major depressive disorder; LUSC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg08200582 chr11:442649 ANO9 -0.55 -5.86 -0.31 1.13e-8 Body mass index; LUSC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 6.16 0.32 2.14e-9 Electroencephalogram traits; LUSC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg07701084 chr6:150067640 NUP43 0.5 7.09 0.36 8.1e-12 Lung cancer; LUSC trans rs10498514 1.000 rs17101854 chr14:64906265 A/G cg05943368 chr17:21179232 NA 0.76 6.66 0.34 1.16e-10 Cognitive performance; LUSC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg26408565 chr15:76604113 ETFA -0.52 -8.3 -0.41 2.6e-15 Blood metabolite levels; LUSC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15541040 chr2:3486749 NA -0.58 -9.21 -0.45 3.59e-18 Neurofibrillary tangles; LUSC cis rs6060717 0.528 rs73905955 chr20:34332938 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -6.25 -0.32 1.24e-9 Hip circumference adjusted for BMI; LUSC trans rs17518584 0.934 rs1991872 chr3:85443793 C/T cg13236679 chr6:37467396 C6orf129 0.46 6.23 0.32 1.41e-9 Cognitive function;Information processing speed; LUSC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg01879757 chr17:41196368 BRCA1 -0.48 -7.4 -0.38 1.12e-12 Menopause (age at onset); LUSC cis rs7131987 0.834 rs7139273 chr12:29434650 T/C cg09582351 chr12:29534625 ERGIC2 -0.3 -6.35 -0.33 7.2e-10 QT interval; LUSC cis rs6430585 0.583 rs79176913 chr2:136638113 C/A cg07169764 chr2:136633963 MCM6 1.23 19.68 0.73 8.47e-58 Corneal structure; LUSC cis rs8062405 1.000 rs8062405 chr16:28837906 C/T cg05966235 chr16:28915196 ATP2A1 -0.33 -5.77 -0.3 1.81e-8 Cognitive ability (multi-trait analysis);Cognitive ability; LUSC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg26441486 chr22:50317300 CRELD2 0.48 7.1 0.36 7.5e-12 Schizophrenia; LUSC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg07741184 chr6:167504864 NA 0.37 6.59 0.34 1.7e-10 Crohn's disease; LUSC cis rs9911578 0.835 rs1476596 chr17:56485358 C/T cg12560992 chr17:57184187 TRIM37 0.71 12.56 0.57 6.54e-30 Intelligence (multi-trait analysis); LUSC cis rs9420 0.961 rs10896647 chr11:57571883 C/T cg23127183 chr11:57508653 C11orf31 -0.58 -8.84 -0.44 5.64e-17 Schizophrenia; LUSC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg12560992 chr17:57184187 TRIM37 0.84 15.27 0.64 2.55e-40 Intelligence (multi-trait analysis); LUSC cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg00530320 chr1:46809349 NSUN4 0.57 8.86 0.44 4.69e-17 Menopause (age at onset); LUSC cis rs1670533 1.000 rs10902752 chr4:1056199 C/T cg02018176 chr4:1364513 KIAA1530 0.44 6.02 0.31 4.62e-9 Recombination rate (females); LUSC cis rs5769765 0.817 rs8142561 chr22:50291750 T/C cg02269571 chr22:50332266 NA -0.55 -8.2 -0.41 5.16e-15 Schizophrenia; LUSC cis rs6815814 0.950 rs5743571 chr4:38805489 C/T cg02016764 chr4:38805732 TLR1 -0.53 -5.74 -0.3 2.16e-8 Breast cancer; LUSC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg00074818 chr8:8560427 CLDN23 0.57 9.83 0.47 3.43e-20 Obesity-related traits; LUSC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg20573242 chr4:122745356 CCNA2 0.44 6.77 0.35 5.65e-11 Type 2 diabetes; LUSC cis rs8141529 0.748 rs132528 chr22:29295898 C/T cg15103426 chr22:29168792 CCDC117 -0.44 -5.7 -0.3 2.69e-8 Lymphocyte counts; LUSC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg06656553 chr16:89960601 TCF25 -0.64 -5.66 -0.3 3.2e-8 Skin colour saturation; LUSC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg09835421 chr16:68378352 PRMT7 -0.54 -6.08 -0.32 3.32e-9 HDL cholesterol;Metabolic syndrome; LUSC trans rs7819412 0.635 rs2409716 chr8:11010748 C/T cg03826601 chr12:9102508 M6PR 0.4 6.42 0.33 4.78e-10 Triglycerides; LUSC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg20476274 chr7:133979776 SLC35B4 0.83 14.99 0.63 3.44e-39 Mean platelet volume; LUSC cis rs2295359 1.000 rs4655683 chr1:67611613 C/T cg12940439 chr1:67600707 NA 0.38 6.54 0.34 2.33e-10 Psoriasis; LUSC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03934478 chr11:495069 RNH1 0.82 9.82 0.47 3.7799999999999997e-20 Body mass index; LUSC trans rs7726839 0.561 rs4957050 chr5:579066 A/C cg25482853 chr8:67687455 SGK3 1.04 15.58 0.65 1.6e-41 Obesity-related traits; LUSC cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.37 -6.85 -0.35 3.47e-11 Monocyte percentage of white cells; LUSC cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 13.78 0.6 1.67e-34 Chronic sinus infection; LUSC cis rs983392 0.709 rs2081547 chr11:59989430 C/T cg20284999 chr11:59952153 MS4A6A -0.37 -6.12 -0.32 2.57e-9 Alzheimer's disease (late onset); LUSC cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.49 -6.9 -0.35 2.57e-11 Monocyte percentage of white cells; LUSC cis rs11605275 0.892 rs16937352 chr11:20032010 G/C cg14835545 chr11:20032148 NAV2 -0.86 -6.53 -0.34 2.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs12579753 1.000 rs2401004 chr12:82214822 T/C cg21231944 chr12:82153410 PPFIA2 -0.39 -5.8 -0.3 1.5e-8 Resting heart rate; LUSC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg02475777 chr4:1388615 CRIPAK 0.45 6.69 0.34 9.62e-11 Obesity-related traits; LUSC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 10.42 0.5 3.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs1941687 0.527 rs2000945 chr18:31365336 A/G cg15819921 chr19:927150 ARID3A -0.43 -6.37 -0.33 6.16e-10 Subjective well-being (multi-trait analysis);Subjective well-being; LUSC cis rs7267979 1.000 rs34645895 chr20:25368373 A/G cg08601574 chr20:25228251 PYGB -0.42 -6.54 -0.34 2.29e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.61 8.55 0.42 4.57e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg24896692 chr6:18387562 RNF144B -0.42 -6.06 -0.31 3.65e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg27121462 chr16:89883253 FANCA 0.55 9.02 0.44 1.52e-17 Vitiligo; LUSC cis rs929354 0.772 rs3802126 chr7:156970281 G/A cg05182265 chr7:156933206 UBE3C -0.59 -9.48 -0.46 4.76e-19 Body mass index; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg15585372 chr7:97910571 BRI3 0.44 5.97 0.31 6.03e-9 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.45 -7.07 -0.36 9.2e-12 Parkinson's disease; LUSC trans rs877282 0.898 rs11253338 chr10:759559 C/T cg22713356 chr15:30763199 NA 0.91 11.94 0.55 1.33e-27 Uric acid levels; LUSC cis rs2742234 0.955 rs2435385 chr10:43665750 A/G cg02780029 chr10:43622663 RET -0.33 -5.92 -0.31 7.93e-9 Hirschsprung disease; LUSC trans rs12439619 0.846 rs28470877 chr15:82538138 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.47 -6.13 -0.32 2.44e-9 Intelligence (multi-trait analysis); LUSC trans rs11992162 0.573 rs13264994 chr8:11782759 G/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.37 -0.33 6.25e-10 Monocyte count; LUSC cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg22431228 chr1:16359049 CLCNKA -0.57 -12.77 -0.57 1.15e-30 Systolic blood pressure; LUSC cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg09626299 chr10:82213104 TSPAN14 -0.2 -5.92 -0.31 8.16e-9 Post bronchodilator FEV1; LUSC cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg25019033 chr10:957182 NA -0.58 -7.75 -0.39 1.14e-13 Eosinophil percentage of granulocytes; LUSC cis rs7605827 0.930 rs2277916 chr2:15494152 C/G cg19274914 chr2:15703543 NA 0.45 8.59 0.43 3.33e-16 Educational attainment (years of education); LUSC cis rs11195062 0.766 rs7897645 chr10:112006669 C/A cg00817464 chr10:111662876 XPNPEP1 -0.4 -5.92 -0.31 8e-9 Multiple myeloma; LUSC cis rs6076065 0.963 rs6048777 chr20:23373302 C/T cg11657817 chr20:23433608 CST11 0.43 8.68 0.43 1.77e-16 Facial morphology (factor 15, philtrum width); LUSC cis rs2692947 0.763 rs7570074 chr2:96407037 T/C cg23100626 chr2:96804247 ASTL 0.26 6.38 0.33 6.08e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg07701084 chr6:150067640 NUP43 0.56 8.55 0.42 4.49e-16 Lung cancer; LUSC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg19592336 chr6:28129416 ZNF389 0.5 6.75 0.35 6.37e-11 Depression; LUSC cis rs1160297 0.609 rs1451455 chr2:53101529 T/C cg07782112 chr2:53107842 NA 0.43 7.14 0.36 5.76e-12 Hemostatic factors and hematological phenotypes; LUSC cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg15744005 chr10:104629667 AS3MT -0.33 -6.78 -0.35 5.33e-11 Arsenic metabolism; LUSC cis rs9875589 0.509 rs4685051 chr3:13981760 A/G cg19554555 chr3:13937349 NA -0.41 -6.08 -0.32 3.37e-9 Ovarian reserve; LUSC cis rs9297145 0.509 rs13222381 chr7:98785024 T/G cg05967295 chr7:98741636 SMURF1 -0.6 -9.17 -0.45 4.92e-18 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; LUSC cis rs12908161 1.000 rs60957376 chr15:85280792 T/G cg17507749 chr15:85114479 UBE2QP1 0.54 6.74 0.35 7.17e-11 Schizophrenia; LUSC cis rs2294693 0.947 rs10456496 chr6:40988840 A/G cg14769373 chr6:40998127 UNC5CL 0.55 8.21 0.41 4.93e-15 Gastric cancer;Non-cardia gastric cancer; LUSC cis rs9815354 0.812 rs10510733 chr3:42009192 T/C cg03022575 chr3:42003672 ULK4 0.82 8.57 0.42 3.93e-16 Pulse pressure;Diastolic blood pressure; LUSC cis rs5769765 0.773 rs138834 chr22:50180497 A/C cg08270630 chr22:50330655 NA -0.38 -5.64 -0.3 3.58e-8 Schizophrenia; LUSC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg20848291 chr7:100343083 ZAN -0.61 -8.65 -0.43 2.13e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; LUSC cis rs11158026 0.757 rs8018800 chr14:55453306 C/T cg04306507 chr14:55594613 LGALS3 -0.38 -7.55 -0.38 4.21e-13 Parkinson's disease; LUSC trans rs2027099 0.606 rs9564321 chr13:67119841 A/G cg18123596 chr17:36956264 PIP4K2B 0.47 6.34 0.33 7.61e-10 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; LUSC cis rs7746199 0.736 rs13202291 chr6:27698857 A/G cg26958806 chr6:27640298 NA 0.74 6.04 0.31 4.02e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; LUSC cis rs4423214 0.840 rs3794057 chr11:71186744 G/A cg05163923 chr11:71159392 DHCR7 -0.77 -10.02 -0.48 7.56e-21 Vitamin D levels; LUSC cis rs1372520 0.684 rs1811442 chr4:90747751 C/T cg15133208 chr4:90757351 SNCA -0.52 -7.97 -0.4 2.52e-14 Neuroticism; LUSC cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg27446573 chr6:127587934 RNF146 0.92 15.2 0.64 4.85e-40 Breast cancer; LUSC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg18876405 chr7:65276391 NA 0.68 11.66 0.54 1.38e-26 Aortic root size; LUSC cis rs34421088 0.586 rs2272594 chr8:11142625 T/C cg21775007 chr8:11205619 TDH 0.5 7.15 0.36 5.55e-12 Neuroticism; LUSC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg22307029 chr19:49891270 CCDC155 0.52 7.0 0.36 1.41e-11 Multiple sclerosis; LUSC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg17143192 chr8:8559678 CLDN23 0.66 9.26 0.45 2.46e-18 Obesity-related traits; LUSC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg17366294 chr4:99064904 C4orf37 0.59 10.6 0.5 8.31e-23 Colonoscopy-negative controls vs population controls; LUSC cis rs16912285 0.636 rs7114960 chr11:24310828 G/A ch.11.24196551F chr11:24239977 NA 0.85 8.87 0.44 4.55e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC trans rs2832191 0.716 rs1888440 chr21:30454484 C/T cg14791747 chr16:20752902 THUMPD1 -0.4 -6.16 -0.32 2.09e-9 Dental caries; LUSC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg24060327 chr5:131705240 SLC22A5 -0.48 -7.76 -0.39 1.04e-13 Breast cancer; LUSC cis rs2282300 0.653 rs12800124 chr11:30239865 A/G cg25418670 chr11:30344373 C11orf46 -0.66 -9.53 -0.46 3.4e-19 Morning vs. evening chronotype; LUSC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg09177884 chr7:1199841 ZFAND2A -0.58 -8.22 -0.41 4.44e-15 Longevity;Endometriosis; LUSC cis rs6754311 0.731 rs4954490 chr2:136608231 G/A cg07169764 chr2:136633963 MCM6 -0.62 -8.08 -0.4 1.22e-14 Mosquito bite size; LUSC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg18301423 chr5:131593218 PDLIM4 0.45 6.84 0.35 3.85e-11 Acylcarnitine levels; LUSC cis rs7216064 1.000 rs2365468 chr17:65841318 C/T cg12091567 chr17:66097778 LOC651250 -0.73 -9.54 -0.46 3.03e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs13385 0.769 rs6871511 chr5:139592314 G/A cg26211634 chr5:139558579 C5orf32 0.45 6.48 0.33 3.27e-10 Atrial fibrillation; LUSC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg27165867 chr14:105738592 BRF1 -0.51 -7.45 -0.38 7.86e-13 Mean platelet volume;Platelet distribution width; LUSC cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg24733560 chr20:60626293 TAF4 0.36 5.84 0.3 1.21e-8 Body mass index; LUSC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg17724175 chr1:150552817 MCL1 0.43 7.43 0.38 9.32e-13 Urate levels; LUSC cis rs2839186 0.967 rs17176131 chr21:47705237 T/C cg12379764 chr21:47803548 PCNT -0.42 -5.97 -0.31 5.91e-9 Testicular germ cell tumor; LUSC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 12.38 0.56 3.16e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs752010 0.619 rs6703992 chr1:42115888 G/A cg06885757 chr1:42089581 HIVEP3 0.57 11.47 0.53 6.46e-26 Lupus nephritis in systemic lupus erythematosus; LUSC trans rs3960554 0.808 rs78340819 chr7:75673833 C/G cg19862616 chr7:65841803 NCRNA00174 0.84 9.49 0.46 4.52e-19 Eotaxin levels; LUSC cis rs9486719 1.000 rs12208124 chr6:97027942 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -10.15 -0.49 2.72e-21 Migraine;Coronary artery disease; LUSC cis rs7089973 0.668 rs10885622 chr10:116643844 C/T cg03647239 chr10:116582469 FAM160B1 0.41 6.23 0.32 1.41e-9 Bipolar disorder or attention deficit hyperactivity disorder; LUSC cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg04117972 chr1:227635322 NA 0.57 6.73 0.35 7.56e-11 Major depressive disorder; LUSC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 11.37 0.53 1.56e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; LUSC cis rs477692 0.699 rs471390 chr10:131382825 A/G cg11019008 chr10:131425282 MGMT -0.39 -5.7 -0.3 2.7e-8 Response to temozolomide; LUSC cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.41e-9 Crohn's disease; LUSC trans rs208515 0.560 rs207084 chr6:66776966 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.2 -24.41 -0.8 2.87e-76 Exhaled nitric oxide levels; LUSC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg12463550 chr7:65579703 CRCP -0.55 -8.35 -0.42 1.82e-15 Aortic root size; LUSC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg18252515 chr7:66147081 NA 1.2 13.62 0.6 6.4e-34 Diabetic kidney disease; LUSC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.82 -0.39 7.17e-14 Lobe attachment (rater-scored or self-reported); LUSC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg21028142 chr17:79581711 NPLOC4 0.32 7.79 0.39 8.41e-14 Eye color traits; LUSC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg15704280 chr7:45808275 SEPT13 -1.12 -24.92 -0.81 3.6e-78 Height; LUSC cis rs1185460 0.967 rs1786685 chr11:118938957 G/A cg01677386 chr11:118938358 VPS11 -0.48 -6.8 -0.35 4.93e-11 Coronary artery disease; LUSC cis rs13401104 0.796 rs72620806 chr2:237113736 C/T cg19324714 chr2:237145437 ASB18 0.43 5.72 0.3 2.35e-8 Educational attainment; LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg02351056 chr10:126480372 METTL10 -0.39 -6.03 -0.31 4.41e-9 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg13395646 chr4:1353034 KIAA1530 0.6 9.08 0.44 9.58e-18 Obesity-related traits; LUSC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg10802521 chr3:52805072 NEK4 -0.55 -8.77 -0.43 9.4e-17 Bipolar disorder; LUSC cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg06784218 chr1:46089804 CCDC17 0.48 9.5 0.46 4.15e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); LUSC cis rs4853012 0.752 rs13413795 chr2:74349839 G/A cg01017244 chr2:74357527 NA 0.71 13.71 0.6 3.06e-34 Gestational age at birth (maternal effect); LUSC cis rs2070488 0.965 rs1065800 chr3:38566480 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.73 -13.47 -0.59 2.41e-33 Electrocardiographic conduction measures; LUSC cis rs4566357 0.930 rs13424003 chr2:227926860 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -5.89 -0.31 9.43e-9 Coronary artery disease; LUSC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg05340658 chr4:99064831 C4orf37 0.66 11.19 0.52 6.63e-25 Colonoscopy-negative controls vs population controls; LUSC cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg23711669 chr6:146136114 FBXO30 -0.82 -14.69 -0.63 4.91e-38 Lobe attachment (rater-scored or self-reported); LUSC trans rs4697263 0.580 rs7657801 chr4:22044236 C/T cg22050897 chr2:236840170 AGAP1 -0.37 -6.34 -0.33 7.29e-10 Age-related hearing impairment (SNP x SNP interaction); LUSC cis rs1405069 0.809 rs1063021 chr6:36932327 A/G cg26433444 chr6:36932349 PI16 0.29 7.03 0.36 1.16e-11 Chemerin levels; LUSC cis rs8028313 0.630 rs3784700 chr15:68017752 A/G cg27219399 chr15:67835830 MAP2K5 0.36 5.74 0.3 2.17e-8 Obesity; LUSC cis rs981844 0.857 rs56198877 chr4:154718970 A/G cg14289246 chr4:154710475 SFRP2 0.47 5.94 0.31 7e-9 Response to statins (LDL cholesterol change); LUSC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg06238570 chr21:40685208 BRWD1 -0.58 -8.76 -0.43 1.02e-16 Menarche (age at onset); LUSC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg07092213 chr7:1199455 ZFAND2A -0.65 -10.53 -0.5 1.44e-22 Longevity;Endometriosis; LUSC cis rs2742417 0.587 rs2742375 chr3:45784602 G/A cg04837898 chr3:45731254 SACM1L -0.45 -7.35 -0.37 1.55e-12 Response to anti-depressant treatment in major depressive disorder; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg07364676 chr22:29137974 CHEK2;HSCB -0.46 -5.96 -0.31 6.37e-9 Bipolar disorder and schizophrenia; LUSC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg23711669 chr6:146136114 FBXO30 -0.94 -17.84 -0.7 1.73e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg11502198 chr6:26597334 ABT1 -0.69 -11.17 -0.52 7.75e-25 Intelligence (multi-trait analysis); LUSC cis rs6424115 0.546 rs35993651 chr1:24180613 C/G cg15997130 chr1:24165203 NA -0.49 -8.05 -0.4 1.42e-14 Immature fraction of reticulocytes; LUSC cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.84 -13.0 -0.58 1.57e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); LUSC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg25036284 chr2:26402008 FAM59B -0.71 -10.02 -0.48 7.79e-21 Gut microbiome composition (summer); LUSC cis rs11583043 0.918 rs17525451 chr1:101422409 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.85 0.35 3.59e-11 Ulcerative colitis;Inflammatory bowel disease; LUSC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg06634786 chr22:41940651 POLR3H 0.53 6.15 0.32 2.2e-9 Vitiligo; LUSC cis rs72781680 0.706 rs72794290 chr2:23896106 A/T cg08917208 chr2:24149416 ATAD2B 0.98 9.61 0.47 1.76e-19 Lymphocyte counts; LUSC cis rs5769765 0.542 rs5769751 chr22:50242733 T/G cg22709217 chr22:50311962 ALG12;CRELD2 0.75 6.61 0.34 1.5e-10 Schizophrenia; LUSC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.69 0.6 3.61e-34 Platelet count; LUSC cis rs73195822 0.614 rs73194057 chr12:111216913 T/C cg12870014 chr12:110450643 ANKRD13A 0.61 7.73 0.39 1.28e-13 Itch intensity from mosquito bite; LUSC cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg12219531 chr12:120966889 COQ5 0.6 8.06 0.4 1.39e-14 High light scatter reticulocyte count; LUSC trans rs2243480 1.000 rs1723270 chr7:65469830 T/G cg10756647 chr7:56101905 PSPH 0.85 8.28 0.41 3.01e-15 Diabetic kidney disease; LUSC trans rs1005277 0.691 rs2474558 chr10:38486141 A/C cg17830980 chr10:43048298 ZNF37B 0.57 8.43 0.42 1.05e-15 Extrinsic epigenetic age acceleration; LUSC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg08888203 chr3:10149979 C3orf24 0.64 8.54 0.42 4.67e-16 Alzheimer's disease; LUSC cis rs3820928 0.874 rs1996998 chr2:227840294 C/A cg11843606 chr2:227700838 RHBDD1 -0.52 -7.51 -0.38 5.57e-13 Pulmonary function; LUSC cis rs752010 0.619 rs1123483 chr1:42114198 C/T cg06885757 chr1:42089581 HIVEP3 -0.59 -12.11 -0.55 3.21e-28 Lupus nephritis in systemic lupus erythematosus; LUSC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.52 -7.69 -0.39 1.67e-13 Renal function-related traits (BUN); LUSC cis rs7597155 0.935 rs7589995 chr2:69980427 A/G cg02498382 chr2:70120550 SNRNP27 -0.24 -5.77 -0.3 1.77e-8 Palmitoleic acid (16:1n-7) levels; LUSC cis rs7681440 0.904 rs12331318 chr4:90770255 A/G cg01966878 chr4:90757139 SNCA -0.34 -5.9 -0.31 8.95e-9 Dementia with Lewy bodies; LUSC cis rs10464366 0.746 rs11760807 chr7:39142377 G/A cg10621924 chr7:39171070 POU6F2 0.42 6.26 0.32 1.17e-9 IgG glycosylation; LUSC cis rs360798 0.512 rs360801 chr2:62955387 C/T cg17519650 chr2:63277830 OTX1 0.42 5.91 0.31 8.42e-9 Coronary artery disease; LUSC cis rs2050392 0.517 rs589980 chr10:30756385 T/A cg18806716 chr10:30721971 MAP3K8 -0.62 -9.92 -0.48 1.7e-20 Inflammatory bowel disease; LUSC cis rs7647973 0.626 rs1491985 chr3:49739507 G/C cg03060546 chr3:49711283 APEH 0.65 7.67 0.39 1.84e-13 Menarche (age at onset); LUSC cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg15997130 chr1:24165203 NA 0.52 8.72 0.43 1.37e-16 Immature fraction of reticulocytes; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg08475257 chr11:65819627 SF3B2 -0.41 -6.26 -0.32 1.19e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs62400317 0.614 rs12210292 chr6:44925293 A/G cg18551225 chr6:44695536 NA -0.39 -5.77 -0.3 1.79e-8 Total body bone mineral density; LUSC cis rs6964587 0.967 rs6973896 chr7:91778465 A/G cg01689657 chr7:91764605 CYP51A1 0.32 5.78 0.3 1.69e-8 Breast cancer; LUSC cis rs11190604 1.000 rs10786597 chr10:102291287 C/T cg16342193 chr10:102329863 NA -0.37 -6.64 -0.34 1.26e-10 Palmitoleic acid (16:1n-7) levels; LUSC cis rs35883536 0.647 rs2783693 chr1:101045040 C/T cg06223162 chr1:101003688 GPR88 0.49 9.15 0.45 5.99e-18 Monocyte count; LUSC cis rs7267979 0.586 rs6050431 chr20:25183908 C/T cg08601574 chr20:25228251 PYGB 0.44 6.68 0.34 1e-10 Liver enzyme levels (alkaline phosphatase); LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg05313129 chr8:58192883 C8orf71 -0.51 -5.79 -0.3 1.64e-8 Developmental language disorder (linguistic errors); LUSC cis rs259282 0.514 rs10420153 chr19:33112957 C/T cg27413643 chr19:33165484 ANKRD27;RGS9BP 0.74 10.78 0.51 1.92e-23 Schizophrenia; LUSC cis rs7633857 0.512 rs10936215 chr3:160652271 A/G cg03342759 chr3:160939853 NMD3 -0.41 -5.98 -0.31 5.76e-9 Educational attainment (years of education); LUSC cis rs7568458 0.660 rs2289972 chr2:85766545 C/T cg02493740 chr2:85810744 VAMP5 -0.53 -9.37 -0.46 1.14e-18 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); LUSC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg07936489 chr17:37558343 FBXL20 -0.73 -10.19 -0.49 2.06e-21 Glomerular filtration rate (creatinine); LUSC cis rs10489202 0.683 rs4657730 chr1:168072738 A/T cg24449463 chr1:168025552 DCAF6 -0.66 -9.84 -0.47 3.03e-20 Schizophrenia; LUSC cis rs11779988 0.545 rs454692 chr8:17789298 T/C cg01800426 chr8:17659068 MTUS1 -0.5 -6.12 -0.32 2.61e-9 Breast cancer; LUSC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg11062466 chr8:58055876 NA 0.76 9.09 0.45 9.22e-18 Developmental language disorder (linguistic errors); LUSC cis rs826838 0.967 rs11168299 chr12:38902028 G/T cg13010199 chr12:38710504 ALG10B 0.69 11.27 0.52 3.59e-25 Heart rate; LUSC trans rs3764796 0.748 rs2904699 chr8:17090798 A/G cg14733031 chr19:17904427 B3GNT3 -0.4 -6.52 -0.34 2.61e-10 Calcium levels; LUSC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg20406979 chr6:167373233 NA 0.27 6.21 0.32 1.61e-9 Crohn's disease; LUSC cis rs2281845 0.507 rs10800760 chr1:201100439 G/A cg22815214 chr1:201083145 CACNA1S 0.43 5.9 0.31 8.71e-9 Permanent tooth development; LUSC cis rs9308433 0.529 rs904321 chr1:214506550 G/C cg06198575 chr1:214491504 SMYD2 0.46 7.19 0.37 4.33e-12 IgG glycosylation; LUSC cis rs7267979 1.000 rs6037095 chr20:25335687 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.86 -19.8 -0.73 2.78e-58 Liver enzyme levels (alkaline phosphatase); LUSC cis rs965469 0.895 rs12626130 chr20:3393192 G/T cg25506879 chr20:3388711 C20orf194 -0.55 -5.77 -0.3 1.84e-8 IFN-related cytopenia; LUSC trans rs7647973 0.710 rs11130208 chr3:49615624 G/T cg21659725 chr3:3221576 CRBN -0.71 -7.82 -0.39 7.08e-14 Menarche (age at onset); LUSC cis rs1577917 0.771 rs2842607 chr6:86345039 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.56 -8.86 -0.44 4.7e-17 Response to antipsychotic treatment; LUSC cis rs5770917 1.000 rs2269384 chr22:51011115 C/T cg06530441 chr22:51016950 CPT1B;CHKB-CPT1B -0.61 -5.7 -0.3 2.69e-8 Narcolepsy; LUSC cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg23711669 chr6:146136114 FBXO30 0.92 17.68 0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs1559088 0.948 rs9304844 chr19:33579935 G/T cg03563238 chr19:33554763 RHPN2 -0.39 -6.24 -0.32 1.3e-9 Bone ultrasound measurement (broadband ultrasound attenuation); LUSC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg13939156 chr17:80058883 NA 0.34 6.73 0.35 7.56e-11 Life satisfaction; LUSC cis rs9473147 0.516 rs1485780 chr6:47556630 A/C cg12968598 chr6:47444699 CD2AP 0.52 7.93 0.4 3.32e-14 Platelet distribution width;Mean platelet volume; LUSC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg13319975 chr6:146136371 FBXO30 0.5 7.48 0.38 6.6e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs11098499 0.954 rs10005644 chr4:120298477 T/C cg09307838 chr4:120376055 NA 0.78 11.27 0.52 3.47e-25 Corneal astigmatism; LUSC cis rs9549367 0.789 rs6577034 chr13:113879900 T/C cg18105134 chr13:113819100 PROZ -0.67 -10.13 -0.48 3.26e-21 Platelet distribution width; LUSC trans rs4332037 0.575 rs55952733 chr7:2070680 G/A cg11693508 chr17:37793320 STARD3 0.51 6.12 0.32 2.69e-9 Bipolar disorder; LUSC cis rs4595586 0.545 rs9669705 chr12:39374459 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.99 0.36 1.51e-11 Morning vs. evening chronotype; LUSC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg01238044 chr22:24384105 GSTT1 -0.51 -7.36 -0.37 1.47e-12 Liver enzyme levels (gamma-glutamyl transferase); LUSC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg13298116 chr11:62369859 EML3;MTA2 0.58 9.48 0.46 4.76e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; LUSC trans rs7826238 0.566 rs2945886 chr8:8148270 C/G cg21775007 chr8:11205619 TDH 0.45 6.36 0.33 6.62e-10 Systolic blood pressure; LUSC cis rs6060717 0.653 rs2590962 chr20:34615363 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -6.37 -0.33 6.14e-10 Hip circumference adjusted for BMI; LUSC cis rs11158026 0.603 rs67571433 chr14:55447982 A/G cg04306507 chr14:55594613 LGALS3 0.4 7.42 0.38 9.78e-13 Parkinson's disease; LUSC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg15605315 chr1:45957053 TESK2 0.49 8.02 0.4 1.74e-14 High light scatter reticulocyte count; LUSC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg23630131 chr7:65973040 NA -0.21 -5.93 -0.31 7.77e-9 Aortic root size; LUSC cis rs992157 0.798 rs2382819 chr2:219155909 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.46 -7.01 -0.36 1.3e-11 Colorectal cancer; LUSC cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg26408565 chr15:76604113 ETFA -0.44 -6.92 -0.35 2.36e-11 Blood metabolite levels; LUSC cis rs62400317 0.859 rs6919873 chr6:45159336 A/G cg18551225 chr6:44695536 NA -0.44 -7.26 -0.37 2.76e-12 Total body bone mineral density; LUSC cis rs3540 0.533 rs11633692 chr15:91056043 G/A cg22089800 chr15:90895588 ZNF774 -0.64 -9.66 -0.47 1.27e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; LUSC cis rs3931020 0.688 rs277396 chr1:75213648 A/C cg26855724 chr1:75198818 TYW3;CRYZ -0.46 -5.84 -0.3 1.24e-8 Resistin levels; LUSC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg14668632 chr7:2872130 GNA12 -0.4 -5.68 -0.3 2.96e-8 Height; LUSC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg12432903 chr7:1882776 MAD1L1 -0.36 -5.82 -0.3 1.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg23262073 chr20:60523788 NA -0.39 -6.24 -0.32 1.36e-9 Body mass index; LUSC cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg05347473 chr6:146136440 FBXO30 -0.49 -8.28 -0.41 3.03e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.54 -8.08 -0.4 1.17e-14 Menarche (age at onset); LUSC cis rs6546537 1.000 rs3899666 chr2:69867871 A/G cg10773587 chr2:69614142 GFPT1 0.42 6.48 0.33 3.29e-10 Serum thyroid-stimulating hormone levels; LUSC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg21548813 chr6:291882 DUSP22 -0.7 -11.49 -0.53 5.74e-26 Menopause (age at onset); LUSC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.8 -11.76 -0.54 6.2e-27 Multiple sclerosis; LUSC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg22875332 chr1:76189707 ACADM 0.84 13.87 0.6 7.3e-35 Blood metabolite levels;Acylcarnitine levels; LUSC cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg05347473 chr6:146136440 FBXO30 0.49 8.22 0.41 4.64e-15 Lobe attachment (rater-scored or self-reported); LUSC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg14019146 chr3:50243930 SLC38A3 -0.32 -7.09 -0.36 8.22e-12 Intelligence (multi-trait analysis); LUSC cis rs929354 1.000 rs1182381 chr7:157043473 G/A cg17757837 chr7:157058334 UBE3C -0.91 -15.03 -0.64 2.3e-39 Body mass index; LUSC cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg23158103 chr7:148848205 ZNF398 -0.47 -7.71 -0.39 1.5e-13 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; LUSC cis rs6693567 0.565 rs698913 chr1:150299145 G/A cg15654264 chr1:150340011 RPRD2 0.44 7.02 0.36 1.22e-11 Migraine; LUSC cis rs861020 1.000 rs861020 chr1:209977111 A/G cg05527609 chr1:210001259 C1orf107 0.94 12.02 0.55 6.49e-28 Orofacial clefts; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg04279164 chr11:106698694 GUCY1A2 0.42 6.7 0.34 8.61e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs2303282 0.716 rs2587869 chr16:56406926 G/A cg00500540 chr16:56394104 NA -0.44 -7.6 -0.38 3.04e-13 Breast cancer; LUSC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg26597838 chr10:835615 NA 0.99 13.85 0.6 9.05e-35 Eosinophil percentage of granulocytes; LUSC cis rs7267979 1.000 rs6115146 chr20:25304507 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.89 -20.57 -0.75 2.54e-61 Liver enzyme levels (alkaline phosphatase); LUSC trans rs11098499 0.909 rs28668716 chr4:120309875 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.45 6.07 0.32 3.38e-9 Corneal astigmatism; LUSC cis rs35146811 0.659 rs863450 chr7:99821685 C/T cg22906224 chr7:99728672 NA -0.5 -6.94 -0.35 2.09e-11 Coronary artery disease; LUSC cis rs686320 1.000 rs2957267 chr11:65235792 C/T cg21890820 chr11:65308645 LTBP3 0.79 7.96 0.4 2.74e-14 Hip circumference adjusted for BMI; LUSC cis rs453301 0.686 rs3989373 chr8:8911308 G/T cg15556689 chr8:8085844 FLJ10661 -0.55 -8.54 -0.42 4.85e-16 Joint mobility (Beighton score); LUSC trans rs9467711 0.591 rs35335639 chr6:26038681 C/G cg06753689 chr10:1034030 GTPBP4 -0.6 -5.97 -0.31 6.09e-9 Autism spectrum disorder or schizophrenia; LUSC trans rs1814175 0.803 rs11040451 chr11:49650639 C/T cg03929089 chr4:120376271 NA -0.99 -17.56 -0.69 2.27e-49 Height; LUSC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg21132104 chr15:45694354 SPATA5L1 0.57 7.97 0.4 2.54e-14 Homoarginine levels; LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg17074213 chr1:92351695 TGFBR3 0.53 9.13 0.45 6.75e-18 Chronic obstructive pulmonary disease-related biomarkers; LUSC trans rs3824488 0.920 rs16909902 chr9:98236202 C/T cg22789318 chr17:981643 ABR 0.47 6.33 0.33 7.98e-10 Neuroticism; LUSC cis rs1003719 0.679 rs2246285 chr21:38582431 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.65 -9.86 -0.47 2.79e-20 Eye color traits; LUSC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg15534755 chr11:117069859 TAGLN 0.34 5.88 0.31 1.01e-8 Blood protein levels; LUSC cis rs701145 0.938 rs355768 chr3:154045001 A/G cg17054900 chr3:154042577 DHX36 0.82 8.64 0.43 2.31e-16 Coronary artery disease; LUSC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg05861140 chr6:150128134 PCMT1 -0.38 -6.04 -0.31 4.07e-9 Lung cancer; LUSC cis rs7107174 1.000 rs10793304 chr11:78064907 A/G cg27205649 chr11:78285834 NARS2 -0.51 -5.82 -0.3 1.36e-8 Testicular germ cell tumor; LUSC cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg16989719 chr2:238392110 NA -0.36 -6.2 -0.32 1.64e-9 Prostate cancer; LUSC cis rs4343996 0.870 rs7780027 chr7:3386228 T/C cg21248987 chr7:3385318 SDK1 -0.4 -6.63 -0.34 1.33e-10 Motion sickness; LUSC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg18404041 chr3:52824283 ITIH1 -0.57 -11.2 -0.52 5.98e-25 Bipolar disorder; LUSC cis rs2692947 0.832 rs62153679 chr2:96558400 C/T cg23100626 chr2:96804247 ASTL 0.26 6.36 0.33 6.62e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; LUSC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.33 0.62 1.18e-36 Allergic disease (asthma, hay fever or eczema); LUSC cis rs9905704 0.647 rs2286299 chr17:57043367 T/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.41 -0.38 1.03e-12 Testicular germ cell tumor; LUSC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg17971929 chr21:40555470 PSMG1 -0.69 -11.64 -0.54 1.59e-26 Cognitive function; LUSC cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg02891314 chr5:179741120 GFPT2 -0.58 -9.17 -0.45 4.95e-18 Height; LUSC cis rs4737010 0.578 rs4466386 chr8:41679853 A/G cg08923054 chr8:41654455 ANK1 0.35 6.9 0.35 2.59e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; LUSC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg00814883 chr7:100076585 TSC22D4 -0.74 -10.19 -0.49 2.13e-21 Platelet count; LUSC cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg24692254 chr21:30365293 RNF160 0.91 18.43 0.71 7.95e-53 Dental caries; LUSC cis rs6942756 0.774 rs2694574 chr7:128908963 A/G cg02491457 chr7:128862824 NA 0.51 7.71 0.39 1.5e-13 White matter hyperintensity burden; LUSC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg26587870 chr6:27730563 NA -0.64 -6.03 -0.31 4.37e-9 Depression; LUSC cis rs4919694 1.000 rs77969925 chr10:104649357 C/T cg04362960 chr10:104952993 NT5C2 1.14 13.06 0.58 9.2e-32 Arsenic metabolism; LUSC cis rs3767633 0.502 rs2499845 chr1:161933066 G/C cg27519958 chr1:161735129 ATF6 -0.38 -5.9 -0.31 8.79e-9 IgG glycosylation; LUSC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg26924012 chr15:45694286 SPATA5L1 1.12 20.85 0.75 2.06e-62 Homoarginine levels; LUSC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg05025164 chr4:1340916 KIAA1530 0.43 6.42 0.33 4.66e-10 Obesity-related traits; LUSC cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg20283391 chr11:68216788 NA 0.59 8.32 0.41 2.25e-15 Total body bone mineral density; LUSC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg25767906 chr1:53392781 SCP2 0.53 9.69 0.47 9.78e-20 Monocyte count; LUSC cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg01256987 chr12:42539512 GXYLT1 -0.44 -8.5 -0.42 6.62e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); LUSC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg04944784 chr2:26401820 FAM59B -0.77 -11.31 -0.53 2.54e-25 Gut microbiome composition (summer); LUSC cis rs1595825 0.891 rs60129872 chr2:198653192 A/G cg10547527 chr2:198650123 BOLL -0.52 -6.06 -0.31 3.6e-9 Ulcerative colitis; LUSC cis rs9486719 1.000 rs11152959 chr6:96900272 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.86 -0.47 2.69e-20 Migraine;Coronary artery disease; LUSC cis rs8180040 0.729 rs11720439 chr3:47347003 T/G cg16586182 chr3:47516702 SCAP 0.51 7.29 0.37 2.31e-12 Colorectal cancer; LUSC cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg23548719 chr3:101395035 LOC100009676;ZBTB11 0.42 5.93 0.31 7.51e-9 Colonoscopy-negative controls vs population controls; LUSC cis rs1670533 1.000 rs629260 chr4:1086764 A/G cg02018176 chr4:1364513 KIAA1530 0.46 6.45 0.33 3.83e-10 Recombination rate (females); LUSC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg21724239 chr8:58056113 NA 0.77 8.35 0.42 1.81e-15 Developmental language disorder (linguistic errors); LUSC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg22823121 chr1:150693482 HORMAD1 -0.46 -6.76 -0.35 6.28e-11 Melanoma; LUSC cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg21535247 chr6:8435926 SLC35B3 0.59 9.24 0.45 3.06e-18 Motion sickness; LUSC cis rs7804356 1.000 rs3801834 chr7:26852062 T/C cg03456212 chr7:26904342 SKAP2 -0.54 -6.25 -0.32 1.24e-9 Type 1 diabetes; LUSC cis rs8103278 1.000 rs725660 chr19:46262286 C/A cg20908204 chr19:46285434 DMPK -0.46 -8.74 -0.43 1.19e-16 Coronary artery disease; LUSC cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg21545522 chr1:205238299 TMCC2 0.51 9.82 0.47 3.72e-20 Mean corpuscular volume;Mean platelet volume; LUSC trans rs17075286 1 rs17075286 chr3:43230723 C/G cg00455883 chr3:73046007 PPP4R2 -0.47 -6.29 -0.33 1.01e-9 Bipolar disorder and schizophrenia; LUSC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg09877947 chr5:131593287 PDLIM4 0.47 7.28 0.37 2.35e-12 Breast cancer; LUSC cis rs7584330 0.554 rs6736468 chr2:238422228 A/G cg14458575 chr2:238380390 NA 0.47 6.21 0.32 1.54e-9 Prostate cancer; LUSC cis rs28735056 0.565 rs12957336 chr18:77716889 A/G cg20368463 chr18:77673604 PQLC1 -0.59 -9.06 -0.44 1.11e-17 Schizophrenia; LUSC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg20203395 chr5:56204925 C5orf35 -0.46 -6.93 -0.35 2.18e-11 Breast cancer;Breast cancer (early onset); LUSC cis rs714027 0.566 rs4820827 chr22:30477589 T/C cg11564601 chr22:30592435 NA -0.33 -5.71 -0.3 2.52e-8 Lymphocyte counts; LUSC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg23985595 chr17:80112537 CCDC57 -0.33 -6.38 -0.33 6.07e-10 Life satisfaction; LUSC cis rs3087591 1.000 rs9904169 chr17:29572518 C/T cg24425628 chr17:29625626 OMG;NF1 -0.56 -8.19 -0.41 5.62e-15 Hip circumference; LUSC cis rs9660992 0.548 rs1172152 chr1:205220718 T/A cg03948781 chr1:205179583 DSTYK 0.3 5.8 0.3 1.54e-8 Mean corpuscular volume;Mean platelet volume; LUSC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg26695010 chr11:65641043 EFEMP2 0.55 8.47 0.42 7.65e-16 Eosinophil percentage of white cells; LUSC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg17810781 chr1:201082982 CACNA1S 0.34 6.46 0.33 3.65e-10 Permanent tooth development; LUSC cis rs950169 0.649 rs12911612 chr15:84691014 T/C cg11189052 chr15:85197271 WDR73 0.54 6.13 0.32 2.42e-9 Schizophrenia; LUSC cis rs1949733 1.000 rs1880023 chr4:8480831 C/T cg13073564 chr4:8508604 NA 0.45 8.45 0.42 8.87e-16 Response to antineoplastic agents; LUSC cis rs12681287 0.752 rs10435563 chr8:87266060 C/T cg27223183 chr8:87520930 FAM82B -0.45 -5.72 -0.3 2.33e-8 Caudate activity during reward; LUSC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -6.19 -0.32 1.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); LUSC cis rs7592578 0.771 rs1128723 chr2:191366707 A/G cg11845111 chr2:191398756 TMEM194B -0.86 -10.83 -0.51 1.25e-23 Diastolic blood pressure; LUSC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg06873352 chr17:61820015 STRADA 0.72 12.76 0.57 1.22e-30 Prudent dietary pattern; LUSC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21582582 chr3:182698605 DCUN1D1 -0.46 -8.24 -0.41 4.06e-15 Intelligence (multi-trait analysis); LUSC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg10729496 chr3:10149963 C3orf24 0.53 7.17 0.37 4.94e-12 Alzheimer's disease; LUSC cis rs7712401 0.601 rs36099390 chr5:122317719 G/A cg19077854 chr5:122220652 SNX24 -0.43 -9.53 -0.46 3.35e-19 Mean platelet volume; LUSC cis rs17407555 0.601 rs73229828 chr4:10026833 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -6.25 -0.32 1.24e-9 Schizophrenia (age at onset); LUSC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg20203395 chr5:56204925 C5orf35 -0.75 -10.33 -0.49 6.65e-22 Initial pursuit acceleration; LUSC trans rs910316 0.692 rs7156586 chr14:75506230 A/T cg10536369 chr2:170335894 BBS5 0.33 6.1 0.32 2.89e-9 Height; LUSC cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.75 8.76 0.43 9.89e-17 Schizophrenia; LUSC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 7.42 0.38 9.97e-13 Bipolar disorder; LUSC trans rs561341 0.609 rs739800 chr17:30190083 T/A cg20587970 chr11:113659929 NA 0.81 9.8 0.47 4.41e-20 Hip circumference adjusted for BMI; LUSC cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 6.17 0.32 1.95e-9 Tonsillectomy; LUSC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg25427524 chr10:38739819 LOC399744 -0.72 -13.32 -0.59 9.34e-33 Extrinsic epigenetic age acceleration; LUSC cis rs4730250 0.707 rs257378 chr7:106801395 C/G cg02696742 chr7:106810147 HBP1 -0.64 -8.94 -0.44 2.63e-17 Osteoarthritis; LUSC cis rs3764021 0.870 rs10844597 chr12:9874899 G/A cg20894963 chr12:9885564 CLECL1 0.35 7.13 0.36 6.24e-12 Type 1 diabetes; LUSC cis rs8078723 0.966 rs7021 chr17:38153875 T/A cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.82 -0.35 4.38e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); LUSC cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg19789473 chr17:27170043 C17orf63 -0.3 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; LUSC cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg08975724 chr8:8085496 FLJ10661 -0.52 -7.39 -0.37 1.19e-12 Mood instability; LUSC cis rs2839186 0.967 rs9637172 chr21:47685787 T/C cg13126279 chr21:47581558 C21orf56 -0.46 -6.82 -0.35 4.19e-11 Testicular germ cell tumor; LUSC cis rs1595825 0.891 rs4491721 chr2:198521407 C/G cg19156104 chr2:198669113 PLCL1 -0.45 -5.69 -0.3 2.74e-8 Ulcerative colitis; LUSC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg26727032 chr16:67993705 SLC12A4 -0.44 -5.87 -0.31 1.05e-8 HDL cholesterol;Metabolic syndrome; LUSC cis rs12908161 0.959 rs12908699 chr15:85240403 G/T cg12863693 chr15:85201151 NMB 0.42 8.65 0.43 2.14e-16 Schizophrenia; LUSC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg16325326 chr1:53192061 ZYG11B 0.94 18.87 0.72 1.39e-54 Monocyte count; LUSC trans rs7824557 0.564 rs2572379 chr8:11237480 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.19e-14 Retinal vascular caliber; LUSC cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg07606381 chr6:8435919 SLC35B3 0.75 12.78 0.57 1.01e-30 Motion sickness; LUSC cis rs2463822 1.000 rs2513076 chr11:62103711 A/G cg06239285 chr11:62104954 ASRGL1 0.97 10.96 0.51 4.58e-24 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg27170947 chr2:26402098 FAM59B -0.69 -10.28 -0.49 1e-21 Gut microbiome composition (summer); LUSC cis rs17270561 0.697 rs9366633 chr6:25838054 A/G cg17691542 chr6:26056736 HIST1H1C 0.49 6.96 0.36 1.79e-11 Iron status biomarkers; LUSC cis rs7507204 0.723 rs12982194 chr19:3411947 G/A cg08380311 chr19:3435252 NFIC 0.7 9.63 0.47 1.59e-19 Height; LUSC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -8.48 -0.42 7.32e-16 Lymphocyte counts; LUSC cis rs10740039 0.883 rs34168977 chr10:62392674 A/C cg18175470 chr10:62150864 ANK3 -0.46 -6.93 -0.35 2.19e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; LUSC cis rs939574 1.000 rs6712442 chr2:220117333 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -1.02 -8.86 -0.44 4.81e-17 Platelet distribution width; LUSC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg14552801 chr7:65878734 NA 0.38 5.79 0.3 1.65e-8 Aortic root size; LUSC cis rs367943 0.965 rs644154 chr5:112799080 G/T cg12552261 chr5:112820674 MCC -0.44 -7.04 -0.36 1.07e-11 Type 2 diabetes; LUSC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.88 12.56 0.57 6.71e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg15704280 chr7:45808275 SEPT13 1.03 18.02 0.7 3.55e-51 Coronary artery disease; LUSC cis rs11676348 0.808 rs61700947 chr2:219046171 C/G cg18102446 chr2:218934044 RUFY4 -0.35 -5.7 -0.3 2.65e-8 Ulcerative colitis; LUSC cis rs721399 0.614 rs4646246 chr8:18248661 A/G cg18736775 chr8:18248649 NAT2 -0.61 -7.48 -0.38 6.67e-13 Blood metabolite levels; LUSC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg14416269 chr4:6271139 WFS1 0.53 11.1 0.52 1.38e-24 Type 2 diabetes and other traits;Type 2 diabetes; LUSC trans rs1432133 0.844 rs12899579 chr15:27224321 C/T cg13064429 chr11:112161200 NA -0.49 -6.28 -0.32 1.06e-9 Hepatitis; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg20804199 chr2:157189308 NR4A2 -0.45 -6.96 -0.36 1.86e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg19378624 chr17:45501242 LOC100272146;C17orf57 -0.37 -6.32 -0.33 8.53e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); LUSC trans rs877282 0.898 rs11253356 chr10:768604 G/A cg22713356 chr15:30763199 NA 0.98 13.6 0.6 7.66e-34 Uric acid levels; LUSC cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg13256891 chr4:100009986 ADH5 0.47 7.17 0.37 4.93e-12 Alcohol dependence; LUSC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg25282410 chr6:160211355 TCP1;MRPL18 1.14 17.39 0.69 1.1e-48 Age-related macular degeneration (geographic atrophy); LUSC cis rs701145 0.556 rs357502 chr3:153955950 C/T cg17054900 chr3:154042577 DHX36 0.45 5.88 0.31 9.8e-9 Coronary artery disease; LUSC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg16405210 chr4:1374714 KIAA1530 -0.59 -9.31 -0.45 1.72e-18 Longevity; LUSC cis rs34779708 0.931 rs11010101 chr10:35411045 T/A cg03585969 chr10:35415529 CREM 0.6 8.96 0.44 2.37e-17 Inflammatory bowel disease;Crohn's disease; LUSC cis rs7605827 0.930 rs11889160 chr2:15605509 C/T cg19274914 chr2:15703543 NA 0.46 8.74 0.43 1.16e-16 Educational attainment (years of education); LUSC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg13319975 chr6:146136371 FBXO30 0.51 7.62 0.39 2.57e-13 Lobe attachment (rater-scored or self-reported); LUSC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg06671706 chr8:8559999 CLDN23 0.48 6.58 0.34 1.86e-10 Obesity-related traits; LUSC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg01802117 chr1:53393560 SCP2 0.41 6.71 0.34 8.26e-11 Monocyte count; LUSC cis rs2404602 0.692 rs34181263 chr15:77065388 C/T cg22467129 chr15:76604101 ETFA -0.44 -7.0 -0.36 1.43e-11 Blood metabolite levels; LUSC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg11645453 chr3:52864694 ITIH4 0.33 7.6 0.38 3.08e-13 Bipolar disorder; LUSC cis rs981844 0.712 rs11099914 chr4:154743519 C/T cg14289246 chr4:154710475 SFRP2 -0.47 -6.38 -0.33 6.04e-10 Response to statins (LDL cholesterol change); LUSC cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.0 -0.44 1.74e-17 Cleft plate (environmental tobacco smoke interaction); LUSC trans rs728616 0.681 rs12769764 chr10:81917113 C/G cg14582970 chr9:125676085 ZBTB6 0.45 6.8 0.35 4.72e-11 Chronic obstructive pulmonary disease-related biomarkers; LUSC cis rs7719624 0.811 rs13159365 chr5:135389433 C/T cg12897067 chr5:135418308 NA -0.44 -6.42 -0.33 4.75e-10 Response to cytidine analogues (gemcitabine); LUSC cis rs870825 0.616 rs6552801 chr4:185620623 G/A cg04058563 chr4:185651563 MLF1IP 0.87 13.38 0.59 5.39e-33 Blood protein levels; LUSC cis rs714027 0.585 rs5752978 chr22:30300586 C/G cg11564601 chr22:30592435 NA 0.34 5.87 0.31 1.02e-8 Lymphocyte counts; LUSC cis rs7511006 1.000 rs5771109 chr22:50678571 T/C cg07895657 chr22:50616420 PANX2 -0.34 -5.96 -0.31 6.37e-9 Obesity-related traits; LUSC cis rs13256369 0.802 rs11995449 chr8:8559898 G/A cg00074818 chr8:8560427 CLDN23 0.6 9.65 0.47 1.36e-19 Obesity-related traits; LUSC cis rs4343996 0.934 rs4495320 chr7:3369936 G/A cg21248987 chr7:3385318 SDK1 -0.4 -6.78 -0.35 5.55e-11 Motion sickness; LUSC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg19230755 chr7:65878503 NA 0.41 5.75 0.3 2e-8 Aortic root size; LUSC trans rs61931739 0.817 rs304313 chr12:34216898 C/T cg24313572 chr1:56050060 NA -0.31 -6.47 -0.33 3.4e-10 Morning vs. evening chronotype; LUSC cis rs2073300 1.000 rs6132621 chr20:23442180 C/T cg09953122 chr20:23471693 CST8 -0.87 -7.32 -0.37 1.86e-12 Peripheral arterial disease (traffic-related air pollution interaction); LUSC cis rs887829 0.570 rs6753320 chr2:234595615 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.36 5.74 0.3 2.09e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; LUSC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg11041457 chr3:52719354 GNL3;PBRM1 -0.36 -5.81 -0.3 1.42e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; LUSC cis rs12545109 0.800 rs2609978 chr8:57394467 T/C cg09654669 chr8:57350985 NA -0.51 -6.78 -0.35 5.55e-11 Obesity-related traits; LUSC cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg23711669 chr6:146136114 FBXO30 0.86 15.52 0.65 2.69e-41 Lobe attachment (rater-scored or self-reported); LUSC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg17366294 chr4:99064904 C4orf37 0.56 9.97 0.48 1.15e-20 Colonoscopy-negative controls vs population controls; LUSC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg04369109 chr6:150039330 LATS1 -0.56 -8.28 -0.41 2.93e-15 Lung cancer; LUSC trans rs10411161 0.702 rs8110073 chr19:52383123 C/A cg22319618 chr22:45562946 NUP50 -0.5 -5.96 -0.31 6.24e-9 Breast cancer; LUSC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg03579872 chr1:53393473 SCP2 0.4 5.73 0.3 2.29e-8 Monocyte count; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg19959648 chr3:197687180 LMLN;IQCG -0.39 -6.07 -0.32 3.38e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs12681287 0.640 rs7832493 chr8:87371533 A/C cg00550725 chr8:87521180 FAM82B -0.43 -5.7 -0.3 2.65e-8 Caudate activity during reward; LUSC cis rs11031096 0.502 rs720571 chr11:4001328 G/T cg08557956 chr11:4115526 RRM1 -0.44 -5.79 -0.3 1.62e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; LUSC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg07414643 chr4:187882934 NA 0.55 10.64 0.5 5.75e-23 Lobe attachment (rater-scored or self-reported); LUSC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg24578937 chr1:2090814 PRKCZ -0.41 -8.94 -0.44 2.71e-17 Height; LUSC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg23281280 chr6:28129359 ZNF389 0.44 5.73 0.3 2.24e-8 Parkinson's disease; LUSC cis rs9611565 0.532 rs4401299 chr22:42156517 A/G cg17376030 chr22:41985996 PMM1 -0.42 -5.71 -0.3 2.56e-8 Vitiligo; LUSC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg07362569 chr17:61921086 SMARCD2 0.37 7.61 0.38 2.83e-13 Prudent dietary pattern; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg05851844 chr12:16035312 STRAP -0.41 -6.05 -0.31 3.79e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs17095355 1.000 rs12259261 chr10:111725145 A/G cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.54 -0.38 4.55e-13 Biliary atresia; LUSC cis rs11622475 1.000 rs12889168 chr14:104481957 A/T cg12183467 chr14:104352244 NA -0.45 -8.19 -0.41 5.66e-15 Bipolar disorder; LUSC cis rs56399783 0.901 rs17241904 chr7:2875574 C/T cg14895029 chr7:2775587 GNA12 0.5 6.11 0.32 2.74e-9 Childhood ear infection; LUSC cis rs2652834 0.851 rs10851724 chr15:63416702 A/T cg05507819 chr15:63340323 TPM1 -0.45 -5.76 -0.3 1.86e-8 HDL cholesterol; LUSC cis rs2486288 0.656 rs2413772 chr15:45549862 G/A cg14582100 chr15:45693742 SPATA5L1 -0.44 -7.9 -0.4 4.09e-14 Glomerular filtration rate; LUSC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg19318889 chr4:1322082 MAEA 0.49 8.06 0.4 1.36e-14 Obesity-related traits; LUSC trans rs7178375 1.000 rs11070678 chr15:31219764 A/G cg04373760 chr16:53404718 NA 0.64 8.74 0.43 1.14e-16 Hypertriglyceridemia; LUSC cis rs6570726 0.967 rs373704 chr6:145860618 C/A cg05347473 chr6:146136440 FBXO30 0.4 6.78 0.35 5.4e-11 Lobe attachment (rater-scored or self-reported); LUSC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg06022373 chr22:39101656 GTPBP1 0.79 12.22 0.56 1.2e-28 Menopause (age at onset); LUSC cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg21535247 chr6:8435926 SLC35B3 0.57 8.78 0.43 8.88e-17 Motion sickness; LUSC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg00814883 chr7:100076585 TSC22D4 -0.73 -9.85 -0.47 2.85e-20 Platelet count; LUSC cis rs11122272 0.735 rs1076804 chr1:231498460 T/C cg06096015 chr1:231504339 EGLN1 0.56 10.05 0.48 6.32e-21 Hemoglobin concentration; LUSC cis rs7465272 1.000 rs13258638 chr8:143683582 C/T cg01509843 chr8:143695822 ARC 0.38 5.73 0.3 2.19e-8 Bipolar disorder and schizophrenia; LUSC cis rs3857536 0.813 rs1029401 chr6:66952268 A/G cg07460842 chr6:66804631 NA -0.46 -6.36 -0.33 6.75e-10 Blood trace element (Cu levels); LUSC cis rs701145 0.585 rs1727954 chr3:153871272 T/A cg17054900 chr3:154042577 DHX36 0.69 6.76 0.35 6.15e-11 Coronary artery disease; LUSC cis rs1178968 0.901 rs7795782 chr7:72766817 T/G cg25889504 chr7:72793014 NA 0.6 7.8 0.39 7.86e-14 Triglyceride levels; LUSC cis rs2282802 0.685 rs6893253 chr5:139661279 T/C cg26211634 chr5:139558579 C5orf32 0.45 8.47 0.42 7.7e-16 Intelligence (multi-trait analysis); LUSC cis rs1355223 0.525 rs7129517 chr11:34872236 A/C cg11058730 chr11:34937778 PDHX;APIP -0.49 -6.95 -0.36 1.9e-11 Systemic lupus erythematosus and Systemic sclerosis; LUSC trans rs6561151 0.681 rs61209988 chr13:44416335 G/C cg12856521 chr11:46389249 DGKZ 0.75 9.64 0.47 1.45e-19 Crohn's disease; LUSC cis rs7824557 0.767 rs2164272 chr8:11162496 A/C cg27411982 chr8:10470053 RP1L1 0.37 5.84 0.3 1.26e-8 Retinal vascular caliber; LUSC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg12564285 chr5:131593104 PDLIM4 0.35 6.42 0.33 4.67e-10 Blood metabolite levels; LUSC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg05535760 chr7:792225 HEATR2 0.95 9.8 0.47 4.32e-20 Cerebrospinal P-tau181p levels; LUSC trans rs7647973 0.710 rs6446284 chr3:49616997 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.47 -0.38 6.98e-13 Menarche (age at onset); LUSC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg21724239 chr8:58056113 NA 0.69 8.86 0.44 4.77e-17 Developmental language disorder (linguistic errors); LUSC cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.01 14.21 0.61 3.55e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); LUSC cis rs59698941 0.527 rs11742089 chr5:132178930 G/A cg14825688 chr5:132208181 LEAP2 -0.44 -6.49 -0.33 3.17e-10 Apolipoprotein A-IV levels; LUSC cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg02380750 chr20:61661411 NA 0.33 5.83 0.3 1.32e-8 Prostate cancer (SNP x SNP interaction); LUSC cis rs4731207 0.967 rs2267708 chr7:124392512 C/T cg14311320 chr7:124405732 GPR37 0.32 6.11 0.32 2.72e-9 Cutaneous malignant melanoma; LUSC cis rs4285028 0.848 rs77630152 chr3:121681194 C/T cg11130432 chr3:121712080 ILDR1 -0.63 -9.59 -0.46 2.19e-19 Multiple sclerosis; LUSC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg18404041 chr3:52824283 ITIH1 -0.58 -11.15 -0.52 9.53e-25 Bipolar disorder; LUSC cis rs765787 0.530 rs1648285 chr15:45517505 C/G cg24006582 chr15:45444508 DUOX1 -0.62 -9.03 -0.44 1.35e-17 Uric acid levels; LUSC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 12.93 0.58 2.87e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; LUSC trans rs11098499 0.955 rs13113112 chr4:120156040 C/T cg25214090 chr10:38739885 LOC399744 0.47 6.82 0.35 4.32e-11 Corneal astigmatism; LUSC cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg01689657 chr7:91764605 CYP51A1 -0.34 -6.16 -0.32 2.11e-9 Breast cancer; LUSC cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.75 12.2 0.56 1.5e-28 Colorectal cancer; LUSC trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg03929089 chr4:120376271 NA -0.77 -10.41 -0.49 3.56e-22 Coronary artery disease; LUSC cis rs5769765 1.000 rs5770742 chr22:50270309 T/C cg22709217 chr22:50311962 ALG12;CRELD2 0.82 10.73 0.51 2.72e-23 Schizophrenia; LUSC trans rs56116032 0.521 rs10738245 chr9:11711490 A/T cg14090374 chr1:85667233 SYDE2 -0.51 -6.65 -0.34 1.19e-10 Neuroticism; LUSC cis rs7954584 0.813 rs11043288 chr12:122451187 C/T cg21016266 chr12:122356598 WDR66 -0.52 -7.81 -0.39 7.41e-14 Mean corpuscular volume; LUSC cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg00631329 chr6:26305371 NA -0.46 -9.18 -0.45 4.58e-18 Educational attainment; LUSC cis rs4746822 0.559 rs4746826 chr10:70985650 G/A cg14418922 chr10:70824840 NA -0.38 -6.61 -0.34 1.49e-10 Glycemic traits (pregnancy); LUSC cis rs7106204 0.748 rs4598670 chr11:24236524 G/A ch.11.24196551F chr11:24239977 NA 1.14 14.86 0.63 1.1e-38 Response to Homoharringtonine (cytotoxicity); LUSC cis rs4808199 0.895 rs4808194 chr19:19435680 T/G cg03709012 chr19:19516395 GATAD2A 0.99 12.09 0.55 3.56e-28 Nonalcoholic fatty liver disease; LUSC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg06915202 chr7:98029285 BAIAP2L1 -0.31 -6.15 -0.32 2.18e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs1413885 0.516 rs7537733 chr1:65838229 G/A cg14976592 chr1:65886160 LEPROT;LEPR 0.48 7.18 0.37 4.6e-12 Anticoagulant levels; LUSC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.66 10.4 0.49 3.84e-22 Cognitive test performance; LUSC cis rs6012953 0.654 rs6020566 chr20:49123032 A/G cg13958625 chr20:49123093 NA 0.28 5.8 0.3 1.52e-8 Vitiligo; LUSC trans rs4729127 1.000 rs4729127 chr7:94008535 A/G cg14660007 chr13:78271894 SLAIN1 0.5 6.45 0.33 3.88e-10 Intelligence; LUSC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 16.33 0.67 1.77e-44 Platelet count; LUSC cis rs8048589 0.604 rs11642033 chr16:12207990 A/G cg02910054 chr16:12241554 SNX29 0.47 6.1 0.32 3.01e-9 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); LUSC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg18904891 chr8:8559673 CLDN23 0.53 7.22 0.37 3.57e-12 Obesity-related traits; LUSC cis rs908922 0.676 rs11205014 chr1:152483634 C/T cg20991723 chr1:152506922 NA 0.52 9.73 0.47 7.34e-20 Hair morphology; LUSC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg18512352 chr11:47633146 NA -0.43 -9.01 -0.44 1.59e-17 Subjective well-being; LUSC cis rs7216064 1.000 rs9912770 chr17:65868233 C/T cg12091567 chr17:66097778 LOC651250 -0.73 -9.37 -0.46 1.13e-18 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; LUSC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg18758796 chr5:131593413 PDLIM4 0.38 6.67 0.34 1.06e-10 Blood metabolite levels; LUSC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.27 5.71 0.3 2.45e-8 Electroencephalogram traits; LUSC trans rs9329221 0.967 rs7005363 chr8:10283748 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.11 -0.32 2.77e-9 Neuroticism; LUSC trans rs13314892 1.000 rs13318796 chr3:69795183 A/G cg24703757 chr4:183838736 DCTD -0.46 -6.31 -0.33 8.76e-10 QRS complex (12-leadsum); LUSC cis rs7809950 0.678 rs17153981 chr7:106922106 A/G cg23024343 chr7:107201750 COG5 -0.67 -10.18 -0.49 2.15e-21 Coronary artery disease; LUSC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg18240062 chr17:79603768 NPLOC4 -0.57 -9.84 -0.47 3.25e-20 Eye color traits; LUSC cis rs9807841 0.592 rs10401513 chr19:10778763 A/T cg09936142 chr19:10668400 KRI1 -0.42 -6.78 -0.35 5.46e-11 Inflammatory skin disease; LUSC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.55 9.71 0.47 8.56e-20 Bipolar disorder; LUSC cis rs4285028 0.948 rs79103597 chr3:121667629 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -9.77 -0.47 5.45e-20 Multiple sclerosis; LUSC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg09467607 chr2:36825704 FEZ2 0.58 13.84 0.6 9.87e-35 Height; LUSC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg11062466 chr8:58055876 NA 0.64 8.5 0.42 6.22e-16 Developmental language disorder (linguistic errors); LUSC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg17971929 chr21:40555470 PSMG1 0.79 13.69 0.6 3.66e-34 Cognitive function; LUSC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg00945038 chr17:61921165 SMARCD2 0.54 9.54 0.46 3.18e-19 Prudent dietary pattern; LUSC cis rs6977660 1.000 rs10240227 chr7:19823188 T/C cg05791153 chr7:19748676 TWISTNB 0.53 5.82 0.3 1.37e-8 Thyroid stimulating hormone; LUSC cis rs281408 0.559 rs281386 chr19:49217305 A/G cg21064579 chr19:49206444 FUT2 -0.37 -6.27 -0.32 1.14e-9 Urinary metabolites (H-NMR features); LUSC cis rs9611565 0.649 rs738422 chr22:42123399 C/T cg17376030 chr22:41985996 PMM1 -0.42 -5.71 -0.3 2.53e-8 Vitiligo; LUSC cis rs3924048 0.559 rs6541037 chr1:12626155 A/G cg00291366 chr1:12616550 NA 0.32 7.32 0.37 1.83e-12 Optic cup area; LUSC cis rs7916697 0.891 rs7897809 chr10:70000293 A/G cg06988349 chr10:69991859 ATOH7 0.34 6.06 0.31 3.66e-9 Optic disc area; LUSC cis rs829883 0.724 rs11109508 chr12:98905985 T/C cg25150519 chr12:98850993 NA -0.64 -8.7 -0.43 1.53e-16 Colorectal adenoma (advanced); LUSC cis rs7246657 0.943 rs7248733 chr19:37996361 A/C cg23950597 chr19:37808831 NA -0.58 -7.02 -0.36 1.23e-11 Coronary artery calcification; LUSC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg20476274 chr7:133979776 SLC35B4 0.81 14.94 0.63 5.36e-39 Mean platelet volume; LUSC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg01879757 chr17:41196368 BRCA1 -0.46 -7.04 -0.36 1.1e-11 Menopause (age at onset); LUSC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg15445000 chr17:37608096 MED1 -0.4 -6.81 -0.35 4.56e-11 Glomerular filtration rate (creatinine); LUSC cis rs11779988 0.528 rs376771 chr8:17864985 G/A cg01800426 chr8:17659068 MTUS1 -0.53 -6.35 -0.33 6.95e-10 Breast cancer; LUSC cis rs10992471 0.756 rs1121979 chr9:95140218 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -8.2 -0.41 5.36e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; LUSC cis rs7575217 0.697 rs2582930 chr2:101721369 T/A cg23907051 chr2:101730305 TBC1D8 -0.29 -7.68 -0.39 1.76e-13 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; LUSC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg16145915 chr7:1198662 ZFAND2A -0.44 -6.35 -0.33 6.91e-10 Bronchopulmonary dysplasia; LUSC cis rs708547 0.836 rs1625691 chr4:57845740 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.54 -7.55 -0.38 4.32e-13 Response to bleomycin (chromatid breaks); LUSC cis rs6496667 0.532 rs2601207 chr15:90963542 C/G cg10434728 chr15:90938212 IQGAP1 -0.32 -6.34 -0.33 7.44e-10 Rheumatoid arthritis; LUSC cis rs11051970 0.918 rs73084099 chr12:32539751 C/T cg24626660 chr12:32551988 NA 0.38 6.07 0.32 3.43e-9 Response to tocilizumab in rheumatoid arthritis; LUSC cis rs9326248 0.813 rs7115562 chr11:117020470 A/G cg26566898 chr11:117069891 TAGLN 0.39 6.12 0.32 2.55e-9 Blood protein levels; LUSC trans rs6928977 0.660 rs12203875 chr6:135860414 C/T cg17957827 chr17:79895524 PYCR1 -0.45 -7.02 -0.36 1.22e-11 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma; LUSC cis rs7760535 0.764 rs240994 chr6:111675757 T/C cg22127309 chr6:111907043 TRAF3IP2 -0.37 -7.01 -0.36 1.36e-11 Metabolic traits; LUSC trans rs13376197 1.000 rs4657785 chr1:194691336 A/G cg05738240 chr12:114337927 RBM19 0.43 5.99 0.31 5.4e-9 Cerebrospinal fluid t-tau:AB1-42 ratio;Cerebrospinal fluid t-tau levels; LUSC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg15448220 chr1:150897856 SETDB1 0.44 6.42 0.33 4.75e-10 Melanoma; LUSC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg20295408 chr7:1910781 MAD1L1 0.41 5.82 0.3 1.41e-8 Bipolar disorder and schizophrenia; LUSC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg17366294 chr4:99064904 C4orf37 0.55 9.63 0.47 1.62e-19 Colonoscopy-negative controls vs population controls; LUSC cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg15839431 chr19:19639596 YJEFN3 -0.65 -7.26 -0.37 2.65e-12 Bipolar disorder; LUSC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22307029 chr19:49891270 CCDC155 0.61 7.78 0.39 9.21e-14 Multiple sclerosis; LUSC cis rs9326248 0.539 rs10892058 chr11:116876621 C/T cg01368799 chr11:117014884 PAFAH1B2 0.58 9.17 0.45 4.9e-18 Blood protein levels; LUSC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11644478 chr21:40555479 PSMG1 0.93 18.29 0.71 2.88e-52 Cognitive function; LUSC cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg08564027 chr20:61660810 NA 0.91 17.49 0.69 4.57e-49 Prostate cancer (SNP x SNP interaction); LUSC trans rs35110281 0.807 rs1598206 chr21:45058776 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.57 9.69 0.47 9.76e-20 Mean corpuscular volume; LUSC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg01341218 chr17:43662625 NA -0.77 -11.3 -0.53 2.68e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; LUSC cis rs9929218 0.529 rs8059194 chr16:68749663 C/T cg01251360 chr16:68772225 CDH1 -0.24 -5.69 -0.3 2.79e-8 Colorectal cancer; LUSC cis rs6736093 1.000 rs6755101 chr2:112658964 T/C cg12686935 chr2:112915763 FBLN7 -0.39 -5.99 -0.31 5.37e-9 Coronary artery disease; LUSC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.59 -7.21 -0.37 3.78e-12 Lung function (FEV1/FVC); LUSC cis rs7586879 0.639 rs6722022 chr2:25098859 A/G cg15423357 chr2:25149977 NA 0.44 8.71 0.43 1.44e-16 Body mass index; LUSC cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg04362960 chr10:104952993 NT5C2 0.59 9.34 0.45 1.43e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); LUSC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg23630131 chr7:65973040 NA 0.2 5.7 0.3 2.57e-8 Aortic root size; LUSC cis rs10489202 0.612 rs3820401 chr1:168074753 T/C cg24449463 chr1:168025552 DCAF6 -0.64 -9.84 -0.47 3.23e-20 Schizophrenia; LUSC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg05313129 chr8:58192883 C8orf71 -0.52 -6.73 -0.35 7.36e-11 Developmental language disorder (linguistic errors); LUSC cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg15544633 chr2:99771531 LIPT1;TSGA10 1.23 30.63 0.86 5.12e-99 Chronic sinus infection; LUSC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg12927641 chr6:109611667 NA -0.43 -7.47 -0.38 7.04e-13 Reticulocyte fraction of red cells; LUSC cis rs7223966 1.000 rs12325866 chr17:61755974 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.74 0.35 6.99e-11 Hip circumference adjusted for BMI;Body mass index; LUSC cis rs11148252 0.574 rs3742297 chr13:53278067 T/C cg00495681 chr13:53174319 NA 0.79 15.67 0.65 7.42e-42 Lewy body disease; LUSC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.24 -0.32 1.32e-9 Alzheimer's disease (late onset); LUSC cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg23711669 chr6:146136114 FBXO30 0.92 17.68 0.7 7.53e-50 Lobe attachment (rater-scored or self-reported); LUSC cis rs11997175 0.624 rs7819074 chr8:33682472 C/T ch.8.33884649F chr8:33765107 NA 0.48 7.11 0.36 7.29e-12 Body mass index; LUSC cis rs6961069 0.585 rs12706916 chr7:80257032 A/G cg04458919 chr7:80252533 CD36 -0.41 -7.28 -0.37 2.49e-12 Platelet count; LUSC cis rs7814319 0.966 rs10095443 chr8:97269738 C/T cg20787634 chr8:97240163 UQCRB -0.35 -6.12 -0.32 2.62e-9 Lung function (FVC); LUSC cis rs258324 0.790 rs8062346 chr16:89732668 G/A cg26513180 chr16:89883248 FANCA 0.75 6.67 0.34 1.08e-10 Height; LUSC cis rs4700695 0.545 rs29441 chr5:65509116 G/T cg21114390 chr5:65439923 SFRS12 -0.51 -7.1 -0.36 7.59e-12 Facial morphology (factor 19); LUSC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg17330251 chr7:94953956 PON1 -0.39 -6.47 -0.33 3.59e-10 Yu-Zhi constitution type in type 2 diabetes; LUSC cis rs2439831 0.850 rs16977798 chr15:44151948 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.78 6.52 0.34 2.52e-10 Lung cancer in ever smokers; LUSC trans rs62238980 0.614 rs1547411 chr22:32443590 T/C cg26675682 chr22:29834657 RFPL1S;RFPL1 -0.51 -6.04 -0.31 4.04e-9 Childhood ear infection; LUSC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg06238570 chr21:40685208 BRWD1 0.47 7.24 0.37 3.13e-12 Cognitive function; LUSC cis rs7674212 0.570 rs2126470 chr4:104061762 T/C cg16532752 chr4:104119610 CENPE -0.5 -7.23 -0.37 3.37e-12 Type 2 diabetes; LUSC cis rs12101261 0.580 rs4411444 chr14:81445108 A/G cg06600135 chr14:81408086 NA 0.47 7.3 0.37 2.12e-12 Graves' disease; LUSC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg10909506 chr17:38081995 ORMDL3 0.34 6.17 0.32 1.97e-9 Self-reported allergy; LUSC cis rs735396 0.770 rs2259820 chr12:121435342 C/T cg02403541 chr12:121454288 C12orf43 0.72 10.41 0.5 3.5e-22 N-glycan levels; LUSC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg17366294 chr4:99064904 C4orf37 0.55 9.03 0.44 1.42e-17 Colonoscopy-negative controls vs population controls; LUSC cis rs9291683 0.526 rs7695555 chr4:10001656 T/C cg00071950 chr4:10020882 SLC2A9 0.52 8.38 0.42 1.47e-15 Bone mineral density; LUSC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg12751644 chr20:60527061 NA -0.38 -6.52 -0.34 2.56e-10 Obesity-related traits; LUSC cis rs7590368 0.926 rs12623588 chr2:10957612 C/G cg15705551 chr2:10952987 PDIA6 -0.53 -7.45 -0.38 8.05e-13 Educational attainment (years of education); LUSC cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 11.99 0.55 8.55e-28 Chronic sinus infection; LUSC cis rs6005807 0.640 rs7289534 chr22:29016057 C/T cg12565055 chr22:29076175 TTC28 0.53 5.77 0.3 1.76e-8 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; LUSC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg12311346 chr5:56204834 C5orf35 -0.92 -13.47 -0.59 2.58e-33 Initial pursuit acceleration; LUSC cis rs7809950 1.000 rs7793613 chr7:107250484 C/T cg23024343 chr7:107201750 COG5 -0.55 -8.69 -0.43 1.62e-16 Coronary artery disease; LUSC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg01475377 chr6:109611718 NA -0.41 -7.26 -0.37 2.7e-12 Reticulocyte fraction of red cells; LUSC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg17385448 chr1:15911702 AGMAT 0.36 6.2 0.32 1.69e-9 Systolic blood pressure; LUSC cis rs7843479 0.965 rs11135741 chr8:21801091 C/T cg17168535 chr8:21777572 XPO7 0.68 10.58 0.5 9.65e-23 Mean corpuscular volume; LUSC trans rs12145833 0.596 rs61833906 chr1:243419706 T/C cg01826367 chr1:224180288 NA 0.67 6.03 0.31 4.42e-9 Obesity (early onset extreme); LUSC cis rs6484504 0.600 rs7122895 chr11:31346620 G/C cg06552810 chr11:31128660 NA 0.39 6.87 0.35 3.24e-11 Red blood cell count; LUSC cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg11584989 chr19:19387371 SF4 0.67 8.2 0.41 5.3e-15 Bipolar disorder; LUSC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg05025164 chr4:1340916 KIAA1530 0.43 6.56 0.34 2.02e-10 Obesity-related traits; LUSC cis rs11971779 0.680 rs10271297 chr7:139052310 A/T cg23387468 chr7:139079360 LUC7L2 0.41 6.22 0.32 1.5e-9 Diisocyanate-induced asthma; LUSC cis rs76878669 0.561 rs55998145 chr11:66152586 A/G cg18002602 chr11:66138449 SLC29A2 0.46 8.31 0.41 2.46e-15 Educational attainment (years of education); LUSC cis rs854765 0.647 rs741782 chr17:18019712 T/C cg04398451 chr17:18023971 MYO15A -0.68 -11.78 -0.54 5.18e-27 Total body bone mineral density; LUSC cis rs9527 0.569 rs78193706 chr10:104780564 T/C cg05855489 chr10:104503620 C10orf26 0.53 8.11 0.41 9.87e-15 Arsenic metabolism; LUSC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18765753 chr7:1198926 ZFAND2A -0.62 -12.62 -0.57 3.87e-30 Longevity;Endometriosis; LUSC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg25039879 chr17:56429692 SUPT4H1 0.66 8.81 0.43 6.99e-17 Cognitive test performance; LUSC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg09267113 chr7:98030324 BAIAP2L1 0.4 6.07 0.32 3.42e-9 Prostate cancer (SNP x SNP interaction); LUSC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg11494091 chr17:61959527 GH2 0.65 13.71 0.6 2.93e-34 Prudent dietary pattern; LUSC cis rs208520 1.000 rs9453671 chr6:66991208 A/G cg07460842 chr6:66804631 NA 0.92 11.99 0.55 8.47e-28 Exhaled nitric oxide output; LUSC cis rs3733606 1.000 rs3733606 chr4:6883012 A/G cg05012661 chr4:6891264 NA -0.46 -6.94 -0.36 1.99e-11 Platelet count; LUSC cis rs9430161 0.579 rs11121669 chr1:11039567 T/C cg02454025 chr1:11042201 C1orf127 0.94 17.91 0.7 9.78e-51 Ewing sarcoma; LUSC cis rs2012796 0.913 rs8010181 chr14:81820125 T/C cg02996355 chr14:81879375 NA 0.46 6.72 0.35 7.88e-11 Night sleep phenotypes; LUSC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg09655341 chr17:79618100 PDE6G -0.28 -6.53 -0.34 2.42e-10 Eye color traits; LUSC cis rs10089 1.000 rs7713877 chr5:127428825 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.87 12.51 0.56 1.06e-29 Ileal carcinoids; LUSC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg13560548 chr3:10150139 C3orf24 0.52 7.16 0.36 5.13e-12 Alzheimer's disease; LUSC cis rs11785400 0.731 rs4294163 chr8:143730830 G/T cg10596483 chr8:143751796 JRK 0.53 7.59 0.38 3.17e-13 Schizophrenia; LUSC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg06453172 chr10:134556979 INPP5A -0.49 -6.13 -0.32 2.51e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); LUSC cis rs2282300 0.696 rs12578061 chr11:30249365 T/A cg25418670 chr11:30344373 C11orf46 -0.66 -9.53 -0.46 3.4e-19 Morning vs. evening chronotype; LUSC cis rs2273669 0.667 rs12214121 chr6:109322554 A/G cg05315195 chr6:109294784 ARMC2 0.53 5.94 0.31 7.18e-9 Prostate cancer; LUSC cis rs9329221 0.905 rs4433149 chr8:10249268 A/T cg27411982 chr8:10470053 RP1L1 -0.49 -8.04 -0.4 1.55e-14 Neuroticism; LUSC trans rs57221529 0.766 rs12521988 chr5:556421 C/T cg08313168 chr12:7315531 NA 0.46 5.98 0.31 5.65e-9 Lung disease severity in cystic fibrosis; LUSC cis rs9467773 0.550 rs9379874 chr6:26440429 A/T cg05738196 chr6:26577821 NA -0.52 -7.72 -0.39 1.37e-13 Intelligence (multi-trait analysis); LUSC cis rs7605827 0.930 rs12692273 chr2:15688834 G/C cg19274914 chr2:15703543 NA 0.45 8.68 0.43 1.82e-16 Educational attainment (years of education); LUSC cis rs7267979 1.000 rs6083828 chr20:25369918 T/C cg03522245 chr20:25566470 NINL -0.35 -5.76 -0.3 1.94e-8 Liver enzyme levels (alkaline phosphatase); LUSC cis rs9399135 0.967 rs13199205 chr6:135286505 T/C cg24558204 chr6:135376177 HBS1L 0.58 8.84 0.44 5.6e-17 Red blood cell count; LUSC cis rs12760731 0.720 rs12072124 chr1:178366990 G/A cg00404053 chr1:178313656 RASAL2 0.57 6.1 0.32 2.87e-9 Obesity-related traits; LUSC cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg13010199 chr12:38710504 ALG10B 0.64 9.96 0.48 1.23e-20 Bladder cancer; LUSC cis rs950169 0.922 rs4586394 chr15:84822385 G/A cg17507749 chr15:85114479 UBE2QP1 -0.65 -8.41 -0.42 1.22e-15 Schizophrenia; LUSC cis rs911119 0.955 rs1555355 chr20:23594580 T/C cg16589663 chr20:23618590 CST3 0.56 6.76 0.35 6.19e-11 Chronic kidney disease; LUSC cis rs1507153 0.812 rs9359337 chr6:79389316 C/T cg05283184 chr6:79620031 NA -0.39 -6.82 -0.35 4.3e-11 Sjögren's syndrome;